diff --git a/.DS_Store b/.DS_Store
index 8f47961..35e8e61 100644
Binary files a/.DS_Store and b/.DS_Store differ
diff --git a/.Rbuildignore b/.Rbuildignore
old mode 100755
new mode 100644
diff --git a/.gitattributes b/.gitattributes
old mode 100755
new mode 100644
diff --git a/.gitignore b/.gitignore
old mode 100755
new mode 100644
index 71a1892..38d8b31
--- a/.gitignore
+++ b/.gitignore
@@ -5,7 +5,3 @@
 *.rds
 *.Rbin
 *.gz
-*.pdf
-*.csv
-*.csv
-*.pdf
diff --git a/DESCRIPTION b/DESCRIPTION
old mode 100755
new mode 100644
index 41590d2..800bc30
--- a/DESCRIPTION
+++ b/DESCRIPTION
@@ -10,13 +10,25 @@ Authors@R: c(
 		 comment = c(ORCID = "0000-0001-8906-5270")))
 Description: Though there are many algorithms for enrichment analysis, most do not perform permutation statistics which do not rely on assumptions about the input distribution and do not allow for analysis of multiple omics data types. This tool enables users to input any omics data type as long as they provide corresponding set annotations or use the default gene set annotations. Users can also use this tool to prioritize drug mechanisms of action based on selective toxicity using drug mechanism enrichment analysis (https://belindabgarana.github.io/DMEA) as long as they provide expression data which corresponds to the input omics data type or use the default CCLE RNA-seq data (version 19Q4) and PRISM drug screen of 327 adherent cancer cell lines.
 License: MIT
-URL: https://github.com/PNNL-CompBio/panSEA
-BugReports: https://github.com/PNNL-CompBio/panSEA/issues
+URL: https://github.com/BelindaBGarana/panSEA
+BugReports: https://github.com/BelindaBGarana/panSEA/issues
 Encoding: UTF-8
-Depends: ggplot2 (>= 3.4.4)
 Imports:
 	ggplot2, DMEA, plyr, dplyr, Biobase, data.table, ggcorrplot, ggvenn, GSA, igraph, 
 	limma, metap, msigdbr, multtest, qvalue, reshape2, stats, stringr, viridis, visNetwork, utils
 VignetteBuilder: knitr
 Suggests: BiocStyle, knitr, rmarkdown
-RoxygenNote: 7.3.3
+Collate:
+	'mDEG.R'
+	'ssGSEA.R'
+	'DMEA_cell_corr.R'
+	'DMEA_gene_corr.R'
+	'compile_mDEG.R'
+	'compile_mGSEA.R'
+	'compile_mDMEA.R'
+	'mGSEA.R'
+	'mDMEA.R'
+	'mDMEA_cell_corr.R'
+	'mDMEA_gene_corr.R'
+	'netSEA.R'
+	'panSEA.R'
diff --git a/DISCLAIMER b/DISCLAIMER
deleted file mode 100644
index a94fefc..0000000
--- a/DISCLAIMER
+++ /dev/null
@@ -1,23 +0,0 @@
-DISCLAIMER
-This material was prepared as an account of work sponsored by an agency of the
-United States Government.  Neither the United States Government nor the United
-States Department of Energy, nor Battelle, nor any of their employees, nor any
-jurisdiction or organization that has cooperated in the development of these
-materials, makes any warranty, express or implied, or assumes any legal
-liability or responsibility for the accuracy, completeness, or usefulness or
-any information, apparatus, product, software, or process disclosed, or
-represents that its use would not infringe privately owned rights.
- 
-Reference herein to any specific commercial product, process, or service by
-trade name, trademark, manufacturer, or otherwise does not necessarily
-constitute or imply its endorsement, recommendation, or favoring by the United
-States Government or any agency thereof, or Battelle Memorial Institute. The
-views and opinions of authors expressed herein do not necessarily state or
-reflect those of the United States Government or any agency thereof.
- 
-                PACIFIC NORTHWEST NATIONAL LABORATORY
-                             operated by
-                               BATTELLE
-                               for the
-                  UNITED STATES DEPARTMENT OF ENERGY
-                   under Contract DE-AC05-76RL01830
diff --git a/Examples/.DS_Store b/Examples/.DS_Store
new file mode 100644
index 0000000..bc40d08
Binary files /dev/null and b/Examples/.DS_Store differ
diff --git a/Examples/Coldren_metabolomics_DEGs.csv b/Examples/Coldren_metabolomics_DEGs.csv
new file mode 100644
index 0000000..d367839
--- /dev/null
+++ b/Examples/Coldren_metabolomics_DEGs.csv
@@ -0,0 +1,226 @@
+"Metabolite","Log2FC"
+"acetylcarnitine",-0.432566808333332
+"acetylcholine",0.0848597708333374
+"acetylglycine",0.157840045833336
+"aconitate",-0.127447645833334
+"adenine",0.0936795041666674
+"adenosine",0.0263129250000027
+"adipate",0.0499140708333332
+"alanine",0.058624316666668
+"allantoin",-0.147068362499999
+"alpha.glycerophosphate",-0.288459241666666
+"alpha.glycerophosphocholine",-0.380057358333332
+"alpha.hydroxybutyrate",0.0414708541666702
+"alpha.ketoglutarate",0.106047975000002
+"AMP",0.0345036250000037
+"anserine",0.00612032500000215
+"anthranilic.acid",-0.573772275
+"arachidonyl_carnitine",0.0517635541666701
+"arginine",-0.151282108333334
+"asparagine",-0.625436620833331
+"aspartate",-0.118030024999996
+"beta.alanine",-0.0878314624999978
+"betaine",-0.0747323833333304
+"butyrobetaine",-0.217442329166664
+"butyrylcarnitine.isobutyrylcarnitine",-0.185442416666666
+"C14.0.CE",-0.201016083333331
+"C14.0.LPC",0.193495700000001
+"C14.0.SM",0.0318908250000014
+"C16.0.CE",-0.0860768249999975
+"C16.0.LPC",-0.0582082916666637
+"C16.0.LPE",-0.106834108333332
+"C16.0.SM",0.0383061291666698
+"C16.1.CE",-0.213105058333332
+"C16.1.LPC",0.0121953375000006
+"C16.1.SM",-0.0237581416666659
+"C18.0.CE",-0.112483837499997
+"C18.0.LPC",-0.0505661749999966
+"C18.0.LPE",-0.0796807458333308
+"C18.0.SM",-0.138665979166664
+"C18.1.CE",-0.256277508333332
+"C18.1.LPC",-0.0934620666666648
+"C18.1.LPE",-0.0887394791666658
+"C18.1.SM",0.0525063541666686
+"C18.2.CE",-0.151707658333332
+"C18.2.LPC",0.0923146625000024
+"C18.2.SM",-0.0858089833333313
+"C18.3.CE",-0.149956962499997
+"C20.3.CE",-0.190236112499997
+"C20.3.LPC",-0.0293843999999979
+"C20.4.CE",-0.0871173249999986
+"C20.4.LPC",0.0415406208333344
+"C20.4.LPE",-0.00236039999999882
+"C20.5.CE",-0.166296941666665
+"C22.0.SM",0.0457310333333361
+"C22.1.SM",-0.0517156083333328
+"C22.6.CE",-0.226050570833332
+"C22.6.LPC",-0.0172023291666656
+"C22.6.LPE",0.136793895833336
+"C24.0.SM",-0.128569124999997
+"C24.1.SM",-0.0921815749999979
+"C32.0.PC",0.0554869708333348
+"C32.1.PC",0.0371743500000026
+"C32.2.PC",-0.071951416666665
+"C34.1.DAG",-0.0341589208333319
+"C34.1.PC",0.0376362250000026
+"C34.2.DAG",0.199680829166669
+"C34.2.PC",0.0245784041666663
+"C34.3.PC",-0.0580227166666658
+"C34.4.PC",0.0265971958333351
+"C36.1.DAG",0.0146541041666675
+"C36.1.PC",0.0190916333333373
+"C36.2.DAG",0.148854970833336
+"C36.2.PC",0.0188580125000026
+"C36.3.PC",-0.0718277958333315
+"C36.4.PC.A",-0.103299541666663
+"C36.4.PC.B",-0.0665448749999964
+"C38.2.PC",-0.012767795833331
+"C38.4.PC",0.0251847791666684
+"C38.5.PC",-0.0858348458333316
+"C38.6.PC",-0.115984387499998
+"C40.6.PC",0.0689353333333358
+"C46.0.TAG",0.0534822125000014
+"C46.1.TAG",0.120444508333335
+"C46.2.TAG",0.168058041666668
+"C48.0.TAG",-0.0120636916666639
+"C48.1.TAG",0.0866925250000019
+"C48.2.TAG",0.247110458333335
+"C48.3.TAG",0.121198904166668
+"C50.0.TAG",-0.090532370833329
+"C50.1.TAG",-0.0312308249999997
+"C50.2.TAG",0.14392116666667
+"C50.3.TAG",0.260920037500002
+"C52.1.TAG",0.0282836291666682
+"C52.2.TAG",0.0721745083333349
+"C52.3.TAG",0.211299400000001
+"C52.4.TAG",0.291782162500001
+"C52.5.TAG",0.186186879166669
+"C54.1.TAG",0.145608716666671
+"C54.2.TAG",0.113122495833332
+"C54.3.TAG",0.165381579166669
+"C54.4.TAG",0.318235354166669
+"C54.5.TAG",0.2507256625
+"C54.6.TAG",0.221204366666665
+"C54.7.TAG",0.143686108333338
+"C56.2.TAG",0.122194420833337
+"C56.3.TAG",0.190865941666667
+"C56.4.TAG",0.336044787500001
+"C56.5.TAG",0.326843391666668
+"C56.6.TAG",0.313725975000002
+"C56.7.TAG",0.131556641666669
+"C56.8.TAG",0.107675116666671
+"C58.6.TAG",0.282476175000001
+"C58.7.TAG",0.308793120833335
+"C58.8.TAG",0.137928808333336
+"cAMP",0.0830368166666684
+"carnitine",-0.177814479166663
+"carnosine",0.00257600000000036
+"choline",0.169593637500004
+"cis.trans.hydroxyproline",-0.545933629166664
+"citrate",-0.084288749999998
+"citrulline",-0.219306595833331
+"CMP",-0.0127537124999968
+"cotinine",0.00411665416666818
+"creatine",-0.00689356666666452
+"creatinine",-0.130710491666663
+"cystathionine",-0.11290623333333
+"cytidine",-0.216521862499998
+"dCMP",0.0360001041666687
+"DHAP.glyceraldehyde.3P",0.0356792791666685
+"dimethylglycine",-0.154732733333331
+"erythrose.4.phosphate",-0.0523152958333295
+"F1P.F6P.G1P.G6P",-0.0382475624999969
+"fumarate.maleate.alpha.ketoisovalerate",0.183663591666668
+"GABA",-0.106485483333331
+"glucuronate",0.101862387500004
+"glutamate",-0.00790752083333235
+"glutamine",0.477598212500003
+"glutathione.oxidized",-0.178272016666662
+"glutathione.reduced",-0.14519688333333
+"glycine",-0.0504685749999974
+"glycodeoxycholate.glycochenodeoxycholate",-0.0807517791666648
+"GMP",-0.10557725
+"guanosine",0.0197052583333344
+"heptanoylcarnitine",0.120376979166669
+"hexanoylcarnitine",-0.190520004166664
+"hexoses..HILIC.neg.",-0.139889699999999
+"hexoses..HILIC.pos.",0.0815303916666679
+"hippurate",-0.0880815583333288
+"histidine",0.0321703250000018
+"homocysteine",-0.456763658333331
+"hypoxanthine",-0.0190687291666647
+"inosine",0.0737183750000021
+"inositol",0.155007966666669
+"isocitrate",-0.0806645124999985
+"isoleucine",0.17260629166667
+"kynurenic.acid",-0.166509737499997
+"kynurenine",-0.0341685083333321
+"lactate",0.0522774875000032
+"lactose",-0.026702129166666
+"lauroylcarnitine",-0.101353045833335
+"leucine",0.0615382541666687
+"lysine",0.19088934166667
+"malate",0.186374954166667
+"malondialdehyde",0.0742086625000038
+"malonylcarnitine",-0.219188966666666
+"methionine",0.26556077916667
+"methionine.sulfoxide",-0.0882254041666641
+"myristoylcarnitine",-0.0374857749999951
+"N.carbamoyl.beta.alanine",0.00985656249999955
+"NAD",0.0373247958333351
+"NADP",-0.129011533333329
+"niacinamide",0.250893058333334
+"NMMA",-0.1059158875
+"oleylcarnitine",-0.0541690208333323
+"ornithine",-0.365185533333332
+"oxalate",0.12767516666667
+"palmitoylcarnitine",-0.063024412499999
+"pantothenate",-0.218344945833331
+"PEP",0.243672191666669
+"phenylalanine",0.161357450000002
+"phosphocreatine",-0.115935191666666
+"pipecolic.acid",-0.152780758333331
+"proline",-0.110353079166665
+"propionylcarnitine",-0.352922133333331
+"putrescine",-0.149027291666666
+"pyroglutamic.acid",0.0284851666666706
+"ribose.5.P.ribulose5.P",0.0654795958333345
+"sarcosine",-0.10880102083333
+"SDMA.ADMA",-0.190176537499998
+"serine",0.295831595833335
+"serotonin",0.0552602458333329
+"sorbitol",-0.0636386999999967
+"stearoylcarnitine",0.0951335583333348
+"succinate.methylmalonate",-0.103723762499999
+"sucrose",0.00522682500000116
+"taurine",-0.215636758333331
+"taurocholate",0.0419375750000004
+"taurodeoxycholate.taurochenodeoxycholate",-0.0820512999999989
+"thiamine",0.206043350000003
+"threonine",0.189575637500001
+"thymidine",-0.643547141666664
+"thymine",0.0567070458333356
+"thyroxine",-0.00779467083333074
+"trimethylamine.N.oxide",0.199691975000002
+"tryptophan",0.00439269166666723
+"tyrosine",0.121640591666667
+"UDP.galactose.UDP.glucose",-0.0511230458333332
+"UMP",0.0627405083333343
+"uracil",0.00209480833333853
+"urate",0.148778220833335
+"uridine",-0.00660626249999652
+"valerylcarnitine.isovalerylcarnitine.2.methylbutyroylcarnitine",0.094920475000003
+"valine",0.216623583333336
+"X1.methylnicotinamide",0.380228920833334
+"X2.aminoadipate",-0.148857954166664
+"X2.deoxyadenosine",-0.258411383333331
+"X2.deoxycytidine",-0.872290891666666
+"X2.hydroxyglutarate",0.113030700000001
+"X3.methyladipate.pimelate",0.0389818500000025
+"X3.phosphoglycerate",0.0838171791666689
+"X4.pyridoxate",0.132790212500002
+"X5.adenosylhomocysteine",0.151265704166669
+"X5.HIAA",-0.0473472458333308
+"X6.phosphogluconate",0.126974662500001
+"xanthine",-0.139633316666665
+"xanthosine",0.0225466583333356
diff --git a/Examples/Coldren_metabolomics_DEGs_before_avg.csv b/Examples/Coldren_metabolomics_DEGs_before_avg.csv
new file mode 100644
index 0000000..923d859
--- /dev/null
+++ b/Examples/Coldren_metabolomics_DEGs_before_avg.csv
@@ -0,0 +1,226 @@
+"Metabolite","Log2FC","AveExpr","t","P.Value","adj.P.Val","B","Log2Transformed"
+"acetylcarnitine",-0.432566808333332,5.96160849,-3.54375838235734,0.00175736278099469,0.156033643163047,-1.16110904842478,FALSE
+"acetylcholine",0.0848597708333374,6.229074175,0.251225587380649,0.803898638778565,0.910438675461403,-5.92575524973369,FALSE
+"acetylglycine",0.157840045833336,5.76356869,1.36651168074923,0.185154817436294,0.722065706826601,-5.08357447358003,FALSE
+"aconitate",-0.127447645833334,5.9082364,-1.18152559162319,0.249617646805812,0.767896083722976,-5.29705401158715,FALSE
+"adenine",0.0936795041666674,5.819529415,0.90431107944152,0.375322741845975,0.780488194251245,-5.56511694660477,FALSE
+"adenosine",0.0263129250000027,6.030221655,0.111309151070361,0.91234898390346,0.979883583871828,-5.95045091585117,FALSE
+"adipate",0.0499140708333332,5.840321505,0.580674177599498,0.567177487666839,0.868205045642314,-5.7933291810421,FALSE
+"alanine",0.058624316666668,5.818558715,0.358425270549357,0.723335012485892,0.89915940885139,-5.89402322381722,FALSE
+"allantoin",-0.147068362499999,5.785034045,-1.47652192223494,0.153534963642831,0.722065706826601,-4.94432614426337,FALSE
+"alpha.glycerophosphate",-0.288459241666666,5.80032633,-1.62228396201603,0.118542705210367,0.672057543268584,-4.74649995876463,FALSE
+"alpha.glycerophosphocholine",-0.380057358333332,5.825983235,-2.04200302868148,0.0529309603689747,0.579393747912754,-4.10023756956233,FALSE
+"alpha.hydroxybutyrate",0.0414708541666702,5.7970432,0.505310572246251,0.618209128864462,0.868205045642314,-5.83269838654661,FALSE
+"alpha.ketoglutarate",0.106047975000002,5.93717756,1.11244176297737,0.277584281901749,0.767896083722976,-5.36983375322221,FALSE
+"AMP",0.0345036250000037,5.838322275,0.437142804905241,0.666135903330892,0.874573158921392,-5.86370701624836,FALSE
+"anserine",0.00612032500000215,5.847879295,0.0579633716698545,0.954284736922955,0.986327843853534,-5.95485339145699,FALSE
+"anthranilic.acid",-0.573772275,6.24255256,-3.68755509941443,0.00123729766510131,0.156033643163047,-0.850976989352204,FALSE
+"arachidonyl_carnitine",0.0517635541666701,5.779710795,0.554773588156459,0.584471924351456,0.868205045642314,-5.80745846562266,FALSE
+"arginine",-0.151282108333334,5.889837785,-1.5957155265458,0.124373588758417,0.672057543268584,-4.7836536778121,FALSE
+"asparagine",-0.625436620833331,5.781932215,-2.81766634809118,0.00983695795840006,0.316187934377145,-2.67146832133942,FALSE
+"aspartate",-0.118030024999996,5.82485171,-1.09418816936278,0.28534104959342,0.767896083722976,-5.38841382257688,FALSE
+"beta.alanine",-0.0878314624999978,6.145741685,-0.49720002238707,0.623826870044512,0.868205045642314,-5.83661775826569,FALSE
+"betaine",-0.0747323833333304,5.807496345,-0.852826808017903,0.402659334119757,0.795681913792805,-5.60769212639161,FALSE
+"butyrobetaine",-0.217442329166664,5.91459829,-1.84236506067303,0.0785152124075286,0.600563264226451,-4.4209778132649,FALSE
+"butyrylcarnitine.isobutyrylcarnitine",-0.185442416666666,5.812360425,-1.46310036455492,0.157141699580094,0.722065706826601,-4.96178838681501,FALSE
+"C14.0.CE",-0.201016083333331,5.92994835,-1.59343502137299,0.12488502663632,0.672057543268584,-4.78682040545313,FALSE
+"C14.0.LPC",0.193495700000001,5.790125895,1.99031276789446,0.0587243387754808,0.579393747912754,-4.18545870776919,FALSE
+"C14.0.SM",0.0318908250000014,5.94583132,0.371803197573404,0.713485523848759,0.89915940885139,-5.88928834781057,FALSE
+"C16.0.CE",-0.0860768249999975,5.81150863,-0.789439964133137,0.438018867175834,0.795681913792805,-5.65690103060004,FALSE
+"C16.0.LPC",-0.0582082916666637,5.765977825,-0.481469032845898,0.634789467247551,0.868205045642314,-5.84404292788517,FALSE
+"C16.0.LPE",-0.106834108333332,5.89714681,-0.784026897856367,0.441124584174283,0.795681913792805,-5.66093765613028,FALSE
+"C16.0.SM",0.0383061291666698,5.93438104,0.380849899469298,0.706853541483186,0.89915940885139,-5.88598937898916,FALSE
+"C16.1.CE",-0.213105058333332,5.814046865,-1.78010026997411,0.0884431581165426,0.625952433803986,-4.51619404661859,FALSE
+"C16.1.LPC",0.0121953375000006,5.83438629,0.106345658219455,0.91624180152931,0.979883583871828,-5.95097752103231,FALSE
+"C16.1.SM",-0.0237581416666659,5.90361299,-0.294072518784895,0.771373129915516,0.910438675461403,-5.91439983892006,FALSE
+"C18.0.CE",-0.112483837499997,5.91126371,-0.937524943236695,0.358351505737389,0.767896083722976,-5.53642557421222,FALSE
+"C18.0.LPC",-0.0505661749999966,5.76672527,-0.392298055631052,0.6984950710802,0.898354456004385,-5.88170258471612,FALSE
+"C18.0.LPE",-0.0796807458333308,5.95196424,-0.495228485748968,0.625196000128243,0.868205045642314,-5.83756113028515,FALSE
+"C18.0.SM",-0.138665979166664,5.84372165,-0.953504345456432,0.350372795735367,0.767896083722976,-5.52228259763382,FALSE
+"C18.1.CE",-0.256277508333332,5.879012845,-2.19491614936379,0.038663803079901,0.573847101529237,-3.83981490399905,FALSE
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+"myristoylcarnitine",-0.0374857749999951,5.82390471,-0.275711384205729,0.785262661033628,0.910438675461403,-5.91948292848311,FALSE
+"N.carbamoyl.beta.alanine",0.00985656249999955,6.234940975,0.0509510246872598,0.959809982698339,0.986327843853534,-5.95522583364339,FALSE
+"NAD",0.0373247958333351,6.019352665,0.362883313037091,0.720047244221038,0.89915940885139,-5.89246441544177,FALSE
+"NADP",-0.129011533333329,6.093039355,-0.678200343868993,0.504496100836678,0.847101661852631,-5.73455043403518,FALSE
+"niacinamide",0.250893058333334,5.87793801,1.68773818079141,0.105147762912609,0.672057543268584,-4.65294914905271,FALSE
+"NMMA",-0.1059158875,5.848291105,-1.04029838270867,0.309149101553153,0.767896083722976,-5.44165882892507,FALSE
+"oleylcarnitine",-0.0541690208333323,5.8244691,-0.315169498589328,0.755510326095898,0.907894794202752,-5.90815830231533,FALSE
+"ornithine",-0.365185533333332,5.825675955,-2.57826664555487,0.016902006865056,0.422550171626401,-3.13859054795301,FALSE
+"oxalate",0.12767516666667,5.74791925,1.29343984116169,0.208859368086851,0.745712943765681,-5.17107009807308,FALSE
+"palmitoylcarnitine",-0.063024412499999,5.722851415,-0.305680952986957,0.762631627130311,0.907894794202752,-5.91101850869733,FALSE
+"pantothenate",-0.218344945833331,5.682582345,-1.64464245459927,0.113814589034293,0.672057543268584,-4.71486445317579,FALSE
+"PEP",0.243672191666669,5.97331039,2.0628655644002,0.0507407616499197,0.579393747912754,-4.06542886425047,FALSE
+"phenylalanine",0.161357450000002,5.90082522,1.40208619365132,0.174408911216652,0.722065706826601,-5.03952031121908,FALSE
+"phosphocreatine",-0.115935191666666,5.940681685,-0.487862285492985,0.630323635072798,0.868205045642314,-5.84105340845411,FALSE
+"pipecolic.acid",-0.152780758333331,5.738777895,-0.640020333802701,0.528563308275259,0.858413693648552,-5.75860593573651,FALSE
+"proline",-0.110353079166665,5.90004334,-1.00835135335016,0.323908003181827,0.767896083722976,-5.47207717936638,FALSE
+"propionylcarnitine",-0.352922133333331,5.967490245,-3.47424103133276,0.00208044857550729,0.156033643163047,-1.31009847210148,FALSE
+"putrescine",-0.149027291666666,5.840766725,-0.753730917594385,0.458753726807112,0.809811020504429,-5.68304508938222,FALSE
+"pyroglutamic.acid",0.0284851666666706,5.90392425,0.251545483233992,0.803654372682733,0.910438675461403,-5.92567703947532,FALSE
+"ribose.5.P.ribulose5.P",0.0654795958333345,5.98366492,0.478763409091823,0.636683700137697,0.868205045642314,-5.84529647250546,FALSE
+"sarcosine",-0.10880102083333,5.8910802,-0.847811782459848,0.405388752458348,0.795681913792805,-5.61171502399814,FALSE
+"SDMA.ADMA",-0.190176537499998,5.79187679,-1.97584389865768,0.0604436126004134,0.579393747912754,-4.20904785475553,FALSE
+"serine",0.295831595833335,5.764224695,2.16898992783056,0.0408069049976346,0.573847101529237,-3.88481343909055,FALSE
+"serotonin",0.0552602458333329,5.73437471,0.325627521488894,0.747687045783179,0.90446013602804,-5.9049055348039,FALSE
+"sorbitol",-0.0636386999999967,5.79275013,-0.596699789094387,0.556609303792566,0.868205045642314,-5.78427420662043,FALSE
+"stearoylcarnitine",0.0951335583333348,5.70790476,0.478914251294713,0.636578027180155,0.868205045642314,-5.84522676765433,FALSE
+"succinate.methylmalonate",-0.103723762499999,5.780365505,-1.17970823050757,0.250325464721373,0.767896083722976,-5.29901799535036,FALSE
+"sucrose",0.00522682500000116,5.97200867,0.0373875157396599,0.970502691180429,0.986327843853534,-5.95581015592281,FALSE
+"taurine",-0.215636758333331,5.974254695,-1.29358768300638,0.20880913871934,0.745712943765681,-5.17089719461631,FALSE
+"taurocholate",0.0419375750000004,5.865602445,0.370747486625592,0.714260967530468,0.89915940885139,-5.88966822316407,FALSE
+"taurodeoxycholate.taurochenodeoxycholate",-0.0820512999999989,5.855596595,-0.24948636316933,0.80522703272924,0.910438675461403,-5.92617873552433,FALSE
+"thiamine",0.206043350000003,5.891745385,1.42930551281002,0.16652709195654,0.722065706826601,-5.00517951421408,FALSE
+"threonine",0.189575637500001,5.91116812,1.55221518471424,0.134434449821015,0.687448891130189,-4.84344260016197,FALSE
+"thymidine",-0.643547141666664,5.76103634,-3.14010565922743,0.00463547124834954,0.208596206175729,-2.01498304703374,FALSE
+"thymine",0.0567070458333356,5.82608264,0.435168529144086,0.667547211221843,0.874573158921392,-5.86453952545491,FALSE
+"thyroxine",-0.00779467083333074,5.84891036,-0.0887276311573097,0.930076081888921,0.979883583871828,-5.95265296744589,FALSE
+"trimethylamine.N.oxide",0.199691975000002,5.737226435,1.29061805968656,0.209819861764208,0.745712943765681,-5.17436698469108,FALSE
+"tryptophan",0.00439269166666723,5.841090565,0.0312539852238635,0.975340004208567,0.986327843853534,-5.95601548193191,FALSE
+"tyrosine",0.121640591666667,5.90813598,1.12141827834396,0.27382644043314,0.767896083722976,-5.36059638526128,FALSE
+"UDP.galactose.UDP.glucose",-0.0511230458333332,5.96889551,-0.505250572919549,0.618250600416914,0.868205045642314,-5.83272760819994,FALSE
+"UMP",0.0627405083333343,5.85299338,0.713036091691152,0.483085543170412,0.829727077964448,-5.71143891048887,FALSE
+"uracil",0.00209480833333853,5.873511835,0.017325999109122,0.986327843853534,0.986327843853534,-5.95634547403144,FALSE
+"urate",0.148778220833335,5.71044677,0.625461806490716,0.537902351509871,0.86223273457461,-5.76742560172371,FALSE
+"uridine",-0.00660626249999652,6.01922288,-0.0472757347977142,0.96270669880437,0.986327843853534,-5.95540188649181,FALSE
+"valerylcarnitine.isovalerylcarnitine.2.methylbutyroylcarnitine",0.094920475000003,5.862197485,0.433749200151871,0.668562592597686,0.874573158921392,-5.86513573829585,FALSE
+"valine",0.216623583333336,5.913222025,1.72256051080979,0.098559044805742,0.667266274239756,-4.60203174444328,FALSE
+"X1.methylnicotinamide",0.380228920833334,6.42159089,0.782426272606404,0.442045507662669,0.795681913792805,-5.6621262517335,FALSE
+"X2.aminoadipate",-0.148857954166664,5.79609929,-1.42148225368757,0.168762657322737,0.722065706826601,-5.01510542468487,FALSE
+"X2.deoxyadenosine",-0.258411383333331,5.86663892,-1.05340587862235,0.303232931812462,0.767896083722976,-5.42893065497974,FALSE
+"X2.deoxycytidine",-0.872290891666666,5.40508224,-3.19078120301735,0.00411015208102516,0.208596206175729,-1.90946896966982,FALSE
+"X2.hydroxyglutarate",0.113030700000001,5.851885945,0.732315441781785,0.471465941828107,0.822324317142047,-5.69817393474358,FALSE
+"X3.methyladipate.pimelate",0.0389818500000025,5.81424546,0.447219973926596,0.658951986447095,0.874573158921392,-5.85940005230971,FALSE
+"X3.phosphoglycerate",0.0838171791666689,6.03914502,0.939111792809672,0.357553757463398,0.767896083722976,-5.53503092288936,FALSE
+"X4.pyridoxate",0.132790212500002,5.75700879,1.08632669394618,0.288729505371174,0.767896083722976,-5.39633135339197,FALSE
+"X5.adenosylhomocysteine",0.151265704166669,5.767066385,1.00596396448026,0.325030298319118,0.767896083722976,-5.47431576794626,FALSE
+"X5.HIAA",-0.0473472458333308,5.781912465,-0.558714912782623,0.581823379352357,0.868205045642314,-5.80534875512554,FALSE
+"X6.phosphogluconate",0.126974662500001,5.97727331,0.695328783420349,0.49390244151901,0.835549243171258,-5.72332489546945,FALSE
+"xanthine",-0.139633316666665,5.87685646,-1.40885813481206,0.172420704861735,0.722065706826601,-5.0310276345838,FALSE
+"xanthosine",0.0225466583333356,5.921166345,0.25324534989224,0.802356732250131,0.910438675461403,-5.92525978520417,FALSE
diff --git a/Examples/Coldren_proteomics_DEGs.csv b/Examples/Coldren_proteomics_DEGs.csv
new file mode 100644
index 0000000..6507417
--- /dev/null
+++ b/Examples/Coldren_proteomics_DEGs.csv
@@ -0,0 +1,12402 @@
+"Gene","Log2FC"
+"A1CF",0.959613002971987
+"A2M",-0.419337043326033
+"A2ML1",1.51205045699892
+"AAAS",0.133520804928437
+"AACS",0.258025475751764
+"AADAT",-1.10211063275207
+"AAGAB",-0.232307726876862
+"AAK1",0.0807659097431152
+"AAMDC",0.0751091358375589
+"AAMP",0.121940711283407
+"AAR2",0.156789014396231
+"AARS",-0.22691812204826
+"AARS2",-0.163631918885402
+"AARSD1",-0.0515842398786605
+"AASDH",NA
+"AASDHPPT",-0.0852976550951934
+"AASS",-0.0806779318139591
+"AATF",-0.586969010973197
+"ABAT",1.2232186533691
+"ABCA1",-0.33491697121459
+"ABCA10",-0.387569720278813
+"ABCA12",1.54928137260566
+"ABCA13",-0.950169257285308
+"ABCA2",-0.0933261329039012
+"ABCA3",-0.877452420152991
+"ABCA4",NA
+"ABCA5",NA
+"ABCA7",-0.85156105472667
+"ABCA8",NA
+"ABCA9",NA
+"ABCB1",-0.416952896227061
+"ABCB10",-0.697039184508175
+"ABCB11",-2.66799589073339
+"ABCB4",-0.671276071947
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+"ABCB8",0.291690777027347
+"ABCC1",-0.501778947961325
+"ABCC10",-0.444993774702597
+"ABCC2",-1.56046804666349
+"ABCC3",0.00114108200971175
+"ABCC4",-0.546367745438277
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+"ABCC6",-0.667350805078949
+"ABCC8",0.0176466474113178
+"ABCD1",-0.11216023609376
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+"ABHD10",-0.132420890273873
+"ABHD11",0.568331677107152
+"ABHD12",0.700417137564036
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+"ABHD6",-0.361040757923722
+"ABI1",-0.0560416345848689
+"ABI2",-0.00369056423450145
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+"ABL1",0.190244411504166
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+"ABLIM1",0.376691977042282
+"ABLIM2",-0.0195777932112487
+"ABLIM3",0.279140263115039
+"ABO",NA
+"ABR",-0.011489906417966
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+"ACACB",-0.0209076484506089
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+"ACAD8",0.717832603389997
+"ACAD9",-0.26838821174683
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+"ACADS",0.399201377166721
+"ACADSB",-0.383467074184652
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+"ACTN1",-0.249702648235425
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+"ACYP1",0.0845773089092388
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+"ADAM15",0.642648581662122
+"ADAM17",0.177401547002581
+"ADAM18",0.177401547002581
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+"ADAM22",NA
+"ADAM28",0.893275237243701
+"ADAM8",1.10308671079129
+"ADAM9",0.368615952946627
+"ADAMTS1",0.513777741130308
+"ADAMTS12",0.450730723103713
+"ADAMTS15",1.46609239528783
+"ADAMTS3",NA
+"ADAMTS4",NA
+"ADAMTS5",NA
+"ADAMTS9",NA
+"ADAMTSL1",-1.47305116560594
+"ADAMTSL4",-1.60003833687413
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+"ADCY5",0.218759164566519
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+"ADD1",-0.318518529931598
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+"ADD3",0.43708132456842
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+"ADGRF1",3.09276047461298
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+"ADGRG1",1.65822358525816
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+"ADGRG6",-1.06955381472029
+"ADGRL1",-0.709114335129037
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+"ADH1C",0.527932473224747
+"ADH4",1.50712923286557
+"ADH5",0.0768532991040506
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+"ADM",NA
+"ADNP",0.295141302476196
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+"ADPGK",0.0216175930710779
+"ADPRH",-0.105646977450071
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+"ADRM1",-0.314479303585131
+"ADSL",0.326544355330072
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+"AFG1L",-1.16323653987508
+"AFG3L2",-0.0412803426864451
+"AFMID",0.77542387197446
+"AFP",0.0105562297604783
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+"ASCL1",NA
+"ASCL2",NA
+"ASF1A",0.00594242500959793
+"ASF1B",1.15933278454529
+"ASGR1",0.64399731325386
+"ASGR2",-1.07453494563336
+"ASH1L",-0.101533491720396
+"ASH2L",-0.227630244287079
+"ASIC2",NA
+"ASIP",-0.110714334530805
+"ASL",0.326544355330072
+"ASMTL",-0.650146133602871
+"ASNA1",-0.576020780212801
+"ASNS",-0.370012266438471
+"ASNSD1",-0.259398458332827
+"ASPA",NA
+"ASPH",0.101345566741132
+"ASPHD1",NA
+"ASPHD2",2.66095389294006
+"ASPM",0.0313147182133388
+"ASPSCR1",-0.483115011610962
+"ASRGL1",0.048674798341423
+"ASS1",0.0699565829105552
+"ASTE1",-0.132006870988625
+"ASXL1",-0.00213107997142193
+"ASXL2",0.208613354511084
+"ASXL3",-0.682339491191717
+"ATAD1",-0.43481585528402
+"ATAD2",0.487768542479046
+"ATAD2B",0.212845611060943
+"ATAD3A",-0.502404200815851
+"ATAD3B",-0.435727038796609
+"ATAD3C",-0.610735817571824
+"ATAD5",0.554018374535892
+"ATAT1",0.453606571731388
+"ATE1",-0.652475355524151
+"ATF1",-0.0287298402551787
+"ATF2",-0.0287298402551787
+"ATF3",-1.26082471853889
+"ATF4",-1.2826722430793
+"ATF5",NA
+"ATF6",-0.0103812942362326
+"ATF6B",0.0871300149376626
+"ATF7",0.0482726569346001
+"ATF7IP",-0.907448709575538
+"ATF7IP2",NA
+"ATG10",NA
+"ATG101",0.138489502424793
+"ATG12",-0.128689314193855
+"ATG13",0.183693332689848
+"ATG14",0.737310005214883
+"ATG16L1",-0.0026819471865105
+"ATG2A",0.350660977388227
+"ATG2B",0.0240319426306039
+"ATG3",-0.30237482360945
+"ATG4A",0.448652295954996
+"ATG4B",-0.196812223441035
+"ATG4C",0.141837626269554
+"ATG4D",NA
+"ATG5",-0.247488104241762
+"ATG7",-0.307321556094114
+"ATG9A",-0.172097427970512
+"ATG9B",-0.04364126635861
+"ATIC",-0.289580555628786
+"ATL1",0.07531133667145
+"ATL2",0.437023751784749
+"ATL3",0.316440107366363
+"ATM",-0.431907102509489
+"ATMIN",0.798648833360508
+"ATN1",0.00788275273494998
+"ATOH1",NA
+"ATOX1",-0.301575481553961
+"ATP10A",1.73456372532518
+"ATP10B",0.663217704079284
+"ATP10D",NA
+"ATP11A",0.0599938375348768
+"ATP11B",0.334574070165738
+"ATP11C",-0.22233248519864
+"ATP12A",0.231403508380328
+"ATP13A1",0.522718938105615
+"ATP13A2",0.198869505480111
+"ATP13A3",-0.180800499285396
+"ATP1A1",0.21008523279417
+"ATP1A2",1.1614043085102
+"ATP1A3",0.234345731399455
+"ATP1A4",0.212198748662818
+"ATP1B1",0.160934722108848
+"ATP1B3",0.0386260364220001
+"ATP23",0.36291206270866
+"ATP2A1",0.361620765096452
+"ATP2A2",0.2003928428039
+"ATP2A3",0.889938095615887
+"ATP2B1",0.18899345771253
+"ATP2B2",0.42673907433125
+"ATP2B3",NA
+"ATP2B4",0.42673907433125
+"ATP2C1",0.237788217335628
+"ATP2C2",1.37387606624172
+"ATP5F1A",-0.44429091618021
+"ATP5F1B",-0.541427969218636
+"ATP5F1C",-0.482841490076988
+"ATP5F1D",-0.35524251631018
+"ATP5F1E",-0.402738029167712
+"ATP5IF1",0.0907150569426632
+"ATP5MC2",-0.603560804412786
+"ATP5MD",-0.627914538365035
+"ATP5ME",-0.60300928917856
+"ATP5MG",-0.465320868124649
+"ATP5MPL",-0.273199466004404
+"ATP5PB",-0.555224790080069
+"ATP5PD",-0.581068376148785
+"ATP5PF",-0.358819695607618
+"ATP5PO",-0.407733978927907
+"ATP5S",-0.208272281400106
+"ATP6AP1",0.101147772742605
+"ATP6AP2",0.429371714949053
+"ATP6V0A1",-0.153104538496512
+"ATP6V0A2",-0.296327140822147
+"ATP6V0A4",0.235379038216639
+"ATP6V0C",0.200766482378304
+"ATP6V0D1",-0.0393305991381894
+"ATP6V0D2",0.23508110044373
+"ATP6V1A",-0.189593514070288
+"ATP6V1B1",0.0682957884069665
+"ATP6V1B2",-0.266170016976016
+"ATP6V1C1",0.0665295163507983
+"ATP6V1C2",0.130584181714363
+"ATP6V1D",0.0303676457960403
+"ATP6V1E1",-0.0170662578872279
+"ATP6V1F",0.217529373817262
+"ATP6V1G1",-0.100431718616881
+"ATP6V1G2",0.106283230628602
+"ATP6V1H",-0.0879208070051906
+"ATP7A",-0.0570415289942106
+"ATP7B",-0.0512634020810843
+"ATP8A1",1.62322780731982
+"ATP8B1",0.779109593450054
+"ATP8B2",NA
+"ATP8B3",-0.0753157755316655
+"ATP9A",0.561133603038525
+"ATP9B",0.262258752163362
+"ATPAF1",0.345272284237206
+"ATPAF2",0.238085509370248
+"ATR",-0.489694245637839
+"ATRAID",0.883549994550468
+"ATRIP",-0.210216440950562
+"ATRN",0.523460809747727
+"ATRNL1",NA
+"ATRX",-0.210317844780168
+"ATXN1",0.087370138349397
+"ATXN10",0.259997104633498
+"ATXN1L",-0.145779726437924
+"ATXN2",-0.300433077248751
+"ATXN2L",-0.241345918903193
+"ATXN3",0.124622761779811
+"ATXN7",0.0593655262821118
+"ATXN7L1",0.358730776869452
+"ATXN7L2",NA
+"ATXN7L3",-0.249197291837685
+"ATXN7L3B",0.276886481406532
+"AUH",0.255395578521376
+"AUP1",-0.278756331605435
+"AURKA",0.689637175199443
+"AURKAIP1",0.11179750446662
+"AURKB",1.27614692034242
+"AUTS2",0.4895453929809
+"AVEN",-0.952927460429947
+"AVIL",NA
+"AVL9",0.127321936246436
+"AVP",0.105680681561834
+"AXIN1",-0.106349252208473
+"AXIN2",NA
+"AXL",-1.44010325268509
+"AZGP1",0.605529038059681
+"AZI2",-0.555515392675932
+"AZIN1",0.663557439102251
+"AZIN2",-0.555515392675932
+"AZU1",NA
+"B2M",0.0407797503858777
+"B3GALNT1",2.48208226570349
+"B3GALNT2",-0.86076030367016
+"B3GALT5",1.07168622113901
+"B3GALT6",0.157511893809356
+"B3GAT3",0.211055237414798
+"B3GLCT",-0.487343103754524
+"B3GNT2",0.441807639754099
+"B3GNT3",1.57255362030986
+"B3GNT6",-0.00480801956128524
+"B3GNT7",NA
+"B3GNT8",0.201839797985702
+"B3GNT9",2.41387243566248
+"B3GNTL1",0.201839797985702
+"B4GALNT1",-1.33112565908138
+"B4GALNT2",NA
+"B4GALNT3",1.72481338478193
+"B4GALNT4",NA
+"B4GALT1",1.11810416450793
+"B4GALT2",NA
+"B4GALT3",0.58825723837049
+"B4GALT4",0.302798762520146
+"B4GALT5",0.852323392029832
+"B4GALT6",NA
+"B4GALT7",0.022898351775654
+"B4GAT1",-0.00480801956128524
+"B9D1",-1.61992416588578
+"B9D2",-1.26615997697729
+"BAALC",1.5400605457799
+"BABAM1",-0.251432418747541
+"BABAM2",-0.234741625633598
+"BACE1",1.91386544280262
+"BACE2",-0.71657553246801
+"BACH1",0.293257268179609
+"BACH2",0.312158527002947
+"BAD",-0.290182671987373
+"BAG1",-0.360360090051445
+"BAG2",-0.842411517516473
+"BAG3",-0.29896309166433
+"BAG4",-0.46903595387434
+"BAG5",0.296847246709966
+"BAG6",0.221769994288707
+"BAHCC1",-0.10763629197124
+"BAHD1",0.380931886096891
+"BAIAP2",1.10662481932624
+"BAIAP2L1",0.462704046779421
+"BAIAP2L2",1.48454555929267
+"BAK1",-0.0271382674276588
+"BANF1",0.0733927623396036
+"BANK1",1.06702968024264
+"BANP",-0.213338906333528
+"BAP1",0.0762900744878235
+"BARD1",0.355542869895899
+"BARHL2",NA
+"BASP1",0.125560786519543
+"BAX",-0.330197051254258
+"BAZ1A",0.20753192255718
+"BAZ1B",-0.506354546275015
+"BAZ2A",0.11940703437573
+"BAZ2B",-0.0878564555267596
+"BBC3",-0.761166114995474
+"BBOX1",-1.2998284381612
+"BBS1",1.97287172837319
+"BBS2",-0.197784843651116
+"BBS4",-0.472552414680967
+"BBS7",-0.345240532749723
+"BBS9",-0.733836353755454
+"BBX",0.186043723571306
+"BCAM",0.58058012892737
+"BCAN",NA
+"BCAP29",0.0801508003595774
+"BCAP31",0.0581930150497081
+"BCAR1",0.204591931860154
+"BCAR3",0.0311088945858379
+"BCAS1",1.61340478605082
+"BCAS2",-0.10657172476602
+"BCAS3",-0.0203112100055615
+"BCAS4",-0.496416411484477
+"BCAT1",-0.65388349341155
+"BCAT2",0.58058012892737
+"BCCIP",-0.445083882317411
+"BCDIN3D",0.538656769713208
+"BCHE",-0.351412846193968
+"BCKDHA",-0.0187618538733395
+"BCKDHB",-0.128928288974595
+"BCKDK",0.466761023977499
+"BCL10",0.162233040714891
+"BCL11A",0.669940200026449
+"BCL11B",0.00384628383105814
+"BCL2",1.95828288340855
+"BCL2A1",NA
+"BCL2L1",-0.642291976703019
+"BCL2L11",0.957637919552173
+"BCL2L12",0.241326711420466
+"BCL2L13",-0.0899431767825545
+"BCL2L14",1.35607746837975
+"BCL2L15",-1.82904103684501
+"BCL2L2",-0.276729722418168
+"BCL3",-0.254575764961558
+"BCL6",-0.572631528288262
+"BCL7A",0.592839884407875
+"BCL7B",0.819807526467552
+"BCL7C",0.775212968267012
+"BCL9",0.250561721154761
+"BCL9L",0.637655409744742
+"BCLAF1",-0.354728464759404
+"BCLAF3",-0.0458536410638818
+"BCOR",0.219982951491023
+"BCORL1",-0.614135316923437
+"BCR",0.481750974157996
+"BCS1L",-0.326189316885152
+"BDH1",0.309407334362635
+"BDH2",0.941433469273372
+"BDP1",-0.226460322863539
+"BECN1",-0.0720465500374757
+"BEND3",-0.33181931084778
+"BEND5",-0.459376877875454
+"BEND7",NA
+"BET1",-0.261497652769039
+"BET1L",0.561995770268186
+"BEX1",NA
+"BEX2",NA
+"BFAR",NA
+"BGN",-0.0800865342400781
+"BHLHE22",NA
+"BHLHE40",0.0328055208135511
+"BHLHE41",0.704585990368615
+"BHMT",0.0339499044913381
+"BHMT2",0.872643206432526
+"BICC1",-1.92986665410577
+"BICD1",0.168402448506311
+"BICD2",0.21373835137924
+"BICDL1",NA
+"BICDL2",1.02703432371355
+"BICRA",0.489641611677474
+"BICRAL",-0.53068778132525
+"BID",-0.072650108508605
+"BIN1",0.839531240375128
+"BIN2",0.482680714325466
+"BIN3",0.16941788367913
+"BIRC2",-0.472322599908785
+"BIRC5",-0.379945185400814
+"BIRC6",-0.141852574601063
+"BIRC7",-0.0509352311781251
+"BLM",-0.257587645595028
+"BLMH",-1.09298421153169
+"BLNK",-1.26324738402329
+"BLOC1S1",-0.235848345370477
+"BLOC1S2",0.0301231299401641
+"BLOC1S3",-0.249327170686647
+"BLOC1S4",-0.00627916636306214
+"BLOC1S5",-0.404950364930309
+"BLOC1S6",NA
+"BLVRA",-0.342840059423437
+"BLVRB",-0.460861425459819
+"BLZF1",-0.110432151971935
+"BMF",NA
+"BMI1",0.178352382815757
+"BMP1",0.935713916675558
+"BMP10",NA
+"BMP2K",0.878234767426929
+"BMP4",NA
+"BMP5",NA
+"BMP6",NA
+"BMP7",NA
+"BMP8B",NA
+"BMPR1A",-1.12183873124178
+"BMPR2",-0.771705377583528
+"BMS1",-0.546465052463416
+"BMT2",1.0868740619708
+"BMX",NA
+"BNC1",NA
+"BNC2",-2.58651851854657
+"BNIP1",-0.0200497400743468
+"BNIP2",-0.659196713751035
+"BNIP3",-0.21185379256542
+"BNIP3L",-0.266960572404474
+"BOC",NA
+"BOD1",-0.145944968781674
+"BOD1L1",0.114223006431644
+"BOK",0.180072639212655
+"BOLA1",-0.147261256430996
+"BOLA2",-0.116384121819253
+"BOLA2B",-0.116384121819253
+"BOLA3",-0.206845850663616
+"BOP1",-0.373593186584586
+"BORA",NA
+"BORCS5",-0.177685909491633
+"BORCS6",-0.210650560681043
+"BORCS7",0.0370857265454047
+"BORCS8",-0.386697220637967
+"BPGM",-0.0950561397845253
+"BPHL",-0.303020431018113
+"BPI",NA
+"BPIFB1",2.67031162117371
+"BPIFB2",NA
+"BPNT1",-0.0126091527185083
+"BPTF",0.258074231464014
+"BRAF",0.0806361374485822
+"BRAP",0.332575445577066
+"BRAT1",-0.289832769365252
+"BRCA1",0.431919571242002
+"BRCA2",-0.020196443500566
+"BRCC3",-0.22933694205348
+"BRD1",-0.0602895338556813
+"BRD2",0.0534340997542114
+"BRD3",0.175490555246667
+"BRD4",-0.113383224763189
+"BRD7",0.076751010675271
+"BRD8",-0.18205561304742
+"BRD9",-0.384893177373362
+"BRDT",-0.0716834686991979
+"BRF1",-0.316934012431648
+"BRF2",0.0896821691432616
+"BRI3",-0.0834465942374483
+"BRI3BP",0.0883330975139062
+"BRIP1",0.293257268179609
+"BRIX1",-0.472711336289475
+"BRK1",0.192294163110486
+"BRMS1",0.0920922427977404
+"BRMS1L",0.0920922427977404
+"BROX",-0.0287681466868416
+"BRPF1",-0.0602895338556813
+"BRPF3",0.000854656466925119
+"BRSK1",0.971219324162275
+"BRSK2",0.504023534046602
+"BRWD1",-0.432349995921898
+"BRWD3",0.565872830184248
+"BSCL2",-0.0649141736515782
+"BSDC1",0.69515330939567
+"BSG",-0.0715523420837483
+"BSN",0.417499569492444
+"BSPRY",2.77730379538795
+"BST1",-0.973330452438877
+"BST2",1.37878171461103
+"BTAF1",-0.0306397312627609
+"BTBD1",0.19364349462279
+"BTBD10",0.197859179633447
+"BTBD11",-2.8070375381042
+"BTBD2",0.473021851217801
+"BTBD3",NA
+"BTBD8",-1.0824846023509
+"BTBD9",0.40211584472789
+"BTD",0.3219927717674
+"BTF3",0.143304055544953
+"BTF3L4",0.388868812469667
+"BTG3",0.192582051740547
+"BTK",-0.0634116018912588
+"BTN2A1",-0.981153917142839
+"BTN3A1",0.197929250269612
+"BTN3A2",0.987768536897766
+"BTN3A3",0.143304055544953
+"BTRC",0.293083975630473
+"BUB1",0.586848765322923
+"BUB1B",0.368345408443797
+"BUB3",-0.167103856870914
+"BUD13",-0.208777878254046
+"BUD23",-0.19056748548225
+"BUD31",-0.477573309064362
+"BVES",-0.0912992444300853
+"BYSL",-0.392417802209218
+"BZW1",0.180726241610517
+"BZW2",0.440729592768415
+"C10orf113",-0.0652258152092636
+"C10orf71",-0.0712207625845651
+"C10orf88",-0.157726129982942
+"C11orf52",1.21315198021788
+"C11orf54",-0.266471278805162
+"C11orf58",-0.480081568607296
+"C11orf68",-0.189413040115432
+"C11orf95",NA
+"C11orf96",NA
+"C12orf10",-0.539580469892758
+"C12orf29",-0.143561189219339
+"C12orf4",-0.140859495852394
+"C12orf43",0.078407363198495
+"C12orf45",-0.283188142400574
+"C12orf57",0.0425871102964645
+"C12orf65",0.12047406200305
+"C12orf66",-1.03338725840096
+"C12orf73",-0.122293468470896
+"C12orf75",-2.37238580148671
+"C14orf119",0.875427329449649
+"C14orf93",0.705960708603672
+"C15orf39",0.531202797928363
+"C15orf40",-0.122531242092551
+"C15orf41",0.086794841720259
+"C15orf48",0.468055500234984
+"C15orf61",-1.00486853422997
+"C16orf45",0.250423633507576
+"C16orf54",NA
+"C16orf58",-0.0517871855194107
+"C16orf70",-0.279620977480581
+"C16orf72",-0.226003334423014
+"C16orf74",NA
+"C16orf86",NA
+"C16orf87",0.202740303366413
+"C16orf91",-0.348235634710007
+"C16orf96",NA
+"C17orf47",0.0938198608207032
+"C17orf49",-0.483826504052679
+"C17orf53",NA
+"C17orf75",0.0205289843846393
+"C17orf80",0.158123411686311
+"C17orf97",-0.524146808403313
+"C18orf21",-0.721351086167826
+"C18orf25",-0.150223418291611
+"C18orf32",-0.413607533446986
+"C19orf12",0.434085729160119
+"C19orf25",0.143439605180703
+"C19orf33",1.90765858860344
+"C19orf44",NA
+"C19orf47",-0.417012744527454
+"C19orf53",0.091411400462838
+"C19orf54",-1.13768715181857
+"C19orf66",0.158090292796159
+"C19orf70",-0.0581165694812435
+"C1D",0.0462744847147993
+"C1GALT1",0.217900672224196
+"C1GALT1C1",0.555293995078305
+"C1orf109",-0.453816763022361
+"C1orf112",0.752722193249285
+"C1orf116",2.03409458652712
+"C1orf122",-0.0316804126252683
+"C1orf123",0.194117495551476
+"C1orf131",-0.0244059445999047
+"C1orf159",0.699202061147821
+"C1orf174",-0.0556746960368688
+"C1orf198",0.680006472576855
+"C1orf21",1.41715460447776
+"C1orf210",1.77984640720152
+"C1orf226",0.914385614858652
+"C1orf35",-0.130422351347621
+"C1orf43",0.160547039552115
+"C1orf50",-0.12487161365574
+"C1orf52",-0.0173446914998825
+"C1orf53",0.09337461793775
+"C1QBP",-0.439980961059216
+"C1QL1",NA
+"C1QTNF6",1.37588926273113
+"C1R",-0.00203534653529902
+"C1RL",0.187307338349445
+"C1S",-2.3848234061652
+"C2",-0.147719632219713
+"C20orf27",-0.250618708397958
+"C21orf91",-0.0660088019675217
+"C22orf39",-0.372785076866484
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+"C2orf49",0.0638379805658118
+"C2orf68",-0.465469310928556
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+"C2orf76",-1.76748699280004
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+"C3orf58",-0.37911812629348
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+"C4BPA",-0.569878493748189
+"C4orf3",0.373463992876979
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+"C6orf106",-0.0913234969883749
+"C6orf132",1.25363853186183
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+"C6orf203",-0.671708867576356
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+"C7",-0.775710255781511
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+"CACNA1F",0.580692758195683
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+"CALCB",NA
+"CALCOCO1",0.287132110505604
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+"CALD1",-1.16979074796544
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+"CALHM5",NA
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+"CSE1L",0.117452848227661
+"CSF1",0.337276224521179
+"CSF2RA",-0.530762814003109
+"CSF2RB",NA
+"CSGALNACT1",1.13244544161136
+"CSGALNACT2",-0.773776870257691
+"CSK",-0.13357440214371
+"CSN2",0.146647836686753
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+"CSNK2B",-0.0252428494423489
+"CSPG4",0.562573375313718
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+"CSRNP2",NA
+"CSRP1",-0.322758583051389
+"CSRP2",-0.87960508881402
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+"CTSL",-0.244183633287313
+"CTSO",-0.481642924039702
+"CTSS",1.648153608243
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+"CTSW",NA
+"CTSZ",-0.151595453343192
+"CTTN",0.571659154084863
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+"CTTNBP2NL",-0.454539301580438
+"CTU1",-0.2260965447348
+"CTU2",-0.325377828695156
+"CUBN",NA
+"CUEDC1",0.309781562857819
+"CUEDC2",-0.557303179687025
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+"CUL2",-0.0760390839032745
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+"CXADR",-0.421761725849122
+"CXCL1",1.75856095933165
+"CXCL10",-0.775710255781511
+"CXCL13",NA
+"CXCL14",-5.5887139778176
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+"CXCL3",NA
+"CXCL5",-1.84573985588226
+"CXCL6",-0.0831393591105601
+"CXCL8",-0.200031235605571
+"CXCR4",0.062154366330821
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+"CXorf49",0.759286293052079
+"CXorf49B",0.759286293052079
+"CXorf56",-0.141809948495516
+"CXorf57",-0.705537307180595
+"CXorf67",NA
+"CXXC1",-0.894405583568713
+"CXXC4",NA
+"CXXC5",1.63554847346224
+"CYB561",1.18252908907723
+"CYB561A3",-0.860814677567258
+"CYB5A",0.649783207083082
+"CYB5B",0.091213834409564
+"CYB5D2",NA
+"CYB5R1",0.157194746520158
+"CYB5R2",0.44650117738742
+"CYB5R3",0.256318205017156
+"CYB5R4",-0.15391016218858
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+"CYBB",NA
+"CYBC1",-0.0331358090791917
+"CYBRD1",-0.722778894867669
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+"CYCS",-0.233239140125067
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+"CYHR1",-0.0942054403147458
+"CYLD",0.138027960228833
+"CYP11A1",NA
+"CYP11B1",NA
+"CYP1A1",0.836005517202888
+"CYP1A2",NA
+"CYP1B1",1.11782444439664
+"CYP20A1",-0.503914362518995
+"CYP21A2",-1.10544516030863
+"CYP24A1",-2.23023119234798
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+"CYP2S1",0.519830018354014
+"CYP2U1",-0.244062818121426
+"CYP2W1",-0.164945359465429
+"CYP3A4",NA
+"CYP3A5",-0.497209892826868
+"CYP3A7",-4.4404364999279
+"CYP4F11",-1.7030697779029
+"CYP4F12",-1.2692363969174
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+"CYP51A1",0.417039310259872
+"CYP7B1",1.17063438283811
+"CYR61",-0.13760363065257
+"CYREN",NA
+"CYSRT1",NA
+"CYSTM1",-0.947561707996241
+"CYTH1",0.125410840124621
+"CYTH2",0.265597666786588
+"CYTH3",0.401780001721834
+"CYTH4",NA
+"CYTIP",NA
+"CYTL1",NA
+"D2HGDH",0.714995633108351
+"DAAM1",1.02409719703899
+"DAAM2",-0.137306968549745
+"DAB1",0.365687796149244
+"DAB2",-0.514574338234125
+"DAB2IP",0.827652081668937
+"DACH1",-0.476505235443617
+"DACH2",NA
+"DAD1",0.0663313953972446
+"DAG1",0.141174869235519
+"DAGLA",0.769429589703294
+"DAGLB",-0.0680022650444233
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+"DAND5",0.01360127555725
+"DAO",0.255430964203553
+"DAP",0.202581783699177
+"DAP3",0.0802868169450225
+"DAPK1",-0.0282841596328314
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+"DAPK3",0.0348154523497815
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+"DAPP1",2.1505921622734
+"DARS",-0.186726823243704
+"DARS2",-0.297845419960973
+"DAXX",-0.234625174195113
+"DAZ1",NA
+"DAZAP1",-0.110516725381929
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+"DBI",0.264747600264772
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+"DCAF13",-0.49808243495794
+"DCAF15",-0.44368597115098
+"DCAF16",0.0906962609006886
+"DCAF17",NA
+"DCAF4",-0.00778810203671032
+"DCAF4L2",-0.775377698019986
+"DCAF5",0.977210255437699
+"DCAF6",0.128381441132983
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+"DCAKD",-0.133843553987062
+"DCBLD1",-0.0393043133763846
+"DCBLD2",-0.0223417775024497
+"DCC",NA
+"DCDC1",0.385630616332804
+"DCDC2",NA
+"DCHS1",NA
+"DCHS2",-0.437785676239211
+"DCK",0.0794944514258091
+"DCLK1",1.43576509887136
+"DCLK2",-0.00653404409279551
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+"DCLRE1A",NA
+"DCLRE1B",-0.629673441544944
+"DCLRE1C",-0.045611936104193
+"DCN",0.228273208932488
+"DCP1A",0.0625864898357315
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+"DDX27",-0.388675194051269
+"DDX28",-0.0970062277931952
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+"DDX39A",-0.392780518581034
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+"DEK",-0.244901243654017
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+"DENND4A",0.263733890875581
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+"DENND5B",-0.488917237673998
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+"DEPDC1B",-0.22933694205348
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+"DEPTOR",0.903415534794058
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+"DIRC2",0.212055141688651
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+"DIS3L2",-0.0396452831799844
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+"DISP1",NA
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+"DIXDC1",0.254504916741814
+"DKC1",-0.362499689633217
+"DKK1",0.579003637441616
+"DKK3",0.738252335147189
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+"DLAT",-0.0324567424009882
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+"DLGAP3",0.0802868169450225
+"DLGAP4",0.619410674533451
+"DLGAP5",0.0448074439656309
+"DLK1",-0.105424770475985
+"DLL1",NA
+"DLL3",-0.0864392108353178
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+"DLST",0.181559390163771
+"DLX1",NA
+"DLX2",-1.80964039360925
+"DLX3",1.58421931039069
+"DLX5",NA
+"DLX6",0.319707662411448
+"DMAC1",-0.57516072155429
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+"DMGDH",0.131199379699105
+"DMKN",0.884607396762357
+"DMP1",0.641423944856694
+"DMPK",NA
+"DMRTA2",NA
+"DMRTB1",NA
+"DMTF1",0.641423944856694
+"DMTN",-0.454634178852407
+"DMWD",NA
+"DMXL1",-0.277046403981557
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+"DNA2",-0.138707435726566
+"DNAAF2",-0.023038020819284
+"DNAAF3",0.944048422240308
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+"DNAH1",NA
+"DNAH11",NA
+"DNAH12",0.129835727697045
+"DNAH2",0.279358651335662
+"DNAH3",-0.446141676780698
+"DNAH5",0.22668701331143
+"DNAH6",0.697018187393674
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+"DNAI1",NA
+"DNAJA1",0.192007554402431
+"DNAJA2",0.0585595810238721
+"DNAJA3",-0.106065439090733
+"DNAJA4",2.34796321700807
+"DNAJB1",0.441195625807624
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+"DNAJB14",0.299377123474214
+"DNAJB2",0.731875665745399
+"DNAJB4",-0.461789920095834
+"DNAJB5",NA
+"DNAJB6",-0.306708177245746
+"DNAJB9",-0.421796490254691
+"DNAJC1",-0.378276164256061
+"DNAJC10",-0.202757087745001
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+"DNAJC19",-0.193858972336118
+"DNAJC2",-0.1771096741858
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+"GABPB1",-0.810568046698168
+"GABPB2",-0.810568046698168
+"GADD45GIP1",0.0490599278385029
+"GAGE12F",NA
+"GAGE2A",6.23639265919414
+"GAK",0.0138972377073083
+"GAL3ST1",NA
+"GAL3ST2",NA
+"GAL3ST3",NA
+"GALC",0.463746017129016
+"GALE",0.386863697488496
+"GALK1",-0.237130192030134
+"GALK2",-0.3762199537328
+"GALM",1.13328995461179
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+"GANC",-0.499933648622023
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+"GAREM1",-2.7858351628401
+"GARS",-0.323166828068779
+"GART",-0.52887514328746
+"GAS1",NA
+"GAS2",NA
+"GAS2L1",-0.120090722840057
+"GAS2L3",0.549686459075169
+"GAS6",-0.13557220346737
+"GAS7",-0.977449094062257
+"GATA1",NA
+"GATA2",-0.472785192048489
+"GATA3",-0.674828203354301
+"GATA4",NA
+"GATA6",-0.194877556169693
+"GATAD1",-0.176363948292608
+"GATAD2A",0.512366303370375
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+"GCH1",NA
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+"GCNT3",7.85956782413037
+"GCSAM",NA
+"GCSAML",NA
+"GCSH",0.418316812958844
+"GDA",-0.359430228149034
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+"GDAP2",-0.42367516057234
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+"GDI1",-0.296564747505175
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+"GEN1",1.16780877471139
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+"GFER",-0.189955129992125
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+"GFI1B",NA
+"GFM1",0.350782652372278
+"GFM2",-0.230496062250241
+"GFOD1",0.637043301839896
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+"GFPT1",0.48406664819661
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+"GGACT",-0.0113224348288896
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+"GGPS1",-0.103820969207705
+"GGT1",-0.391192059259066
+"GGT5",2.03466271278048
+"GGT6",NA
+"GGT7",0.46365151878356
+"GHDC",-0.00815574513639467
+"GHITM",-0.661325979631242
+"GID4",-0.540325057256998
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+"GIGYF2",0.143827348741645
+"GIMAP1",-0.701916922375268
+"GIMAP2",-0.8072437811034
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+"GINM1",0.251757530511439
+"GINS1",0.265738076311729
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+"GIPC1",0.434273011566524
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+"GIT1",0.169177603963058
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+"GJA1",0.554318878054238
+"GJA5",-2.6744186253557
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+"GJB3",0.0518807055370725
+"GJC1",-0.572760125939439
+"GJD3",-0.572760125939439
+"GK",-0.787212711793384
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+"GLE1",-0.0389225617430868
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+"GLIPR1",-0.842929140236856
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+"GLT8D1",-0.0464388973523848
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+"GLTPD2",NA
+"GLUD1",-0.0252667498368334
+"GLUD2",0.658316074673891
+"GLUL",1.58701995710536
+"GLYAT",1.42040211966343
+"GLYATL1",NA
+"GLYATL2",NA
+"GLYCTK",0.385606890565081
+"GLYR1",-0.129815866611151
+"GM2A",0.668780468818355
+"GMCL1",NA
+"GMCL2",NA
+"GMDS",0.11729984171799
+"GMEB1",0.0428955437256645
+"GMEB2",0.158304187185559
+"GMFB",0.0138993906133721
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+"GNAS",0.0287199308701057
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+"GNB1",-0.175106057634887
+"GNB1L",0.325140141988289
+"GNB2",0.358682340616944
+"GNB3",0.254870794719077
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+"GNE",-0.590559369734686
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+"GNG2",0.43463924155728
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+"GOLGA5",0.527263579980201
+"GOLGA7",0.179530910603794
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+"GOLGA8A",NA
+"GOLGA8B",0.527263579980201
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+"GOLGA8Q",NA
+"GOLGB1",0.381789139083397
+"GOLIM4",-0.439806614080109
+"GOLM1",1.49814557181894
+"GOLPH3",0.813862979017586
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+"GREM1",NA
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+"GRHL1",1.34419509285104
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+"GRHPR",-0.182715985116519
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+"GRIN1",-0.0832890467985562
+"GRIP1",0.418116931060083
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+"GSR",-0.458354139182437
+"GSS",-0.0728955613106405
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+"GTSE1",0.129470270460508
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+"GUCY1A1",0.338086465812585
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+"GYG1",-0.318205843965446
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+"GYPB",NA
+"GYPC",0.179357488683813
+"GYPE",NA
+"GYS1",0.327255789052604
+"GZF1",0.317816701706428
+"GZMA",NA
+"GZMB",NA
+"H1F0",0.879778282749054
+"H1FX",-0.679366572007447
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+"H2AFV",-0.333559763975273
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+"HACD1",-0.513060994287444
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+"HACE1",NA
+"HACL1",-0.194799829602443
+"HADH",0.140793777649049
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+"HADHB",-0.194262018647182
+"HAGH",-0.733641101760819
+"HAGHL",0.340856406793233
+"HAL",NA
+"HAND2",NA
+"HAO1",NA
+"HAP1",-0.0951119680370875
+"HAPLN1",-0.598437990240581
+"HAPLN3",0.281420950111924
+"HARS",-0.469266193275219
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+"HAUS8",-0.11644894534635
+"HAVCR1",-2.83285902938256
+"HAVCR2",NA
+"HAX1",-0.419345975033219
+"HBA1",-0.688808285600174
+"HBB",NA
+"HBD",-0.711721726382392
+"HBE1",0.262597163579278
+"HBEGF",-0.5523649265344
+"HBG1",0.250737047821475
+"HBG2",NA
+"HBM",0.630395085195643
+"HBP1",-0.305391292486772
+"HBQ1",NA
+"HBS1L",-0.230784434314337
+"HBZ",NA
+"HCAR2",NA
+"HCCS",-0.0230217459442326
+"HCFC1",-0.00477502763268771
+"HCFC2",-0.29503041120166
+"HCK",0.748822767062306
+"HCLS1",0.0553729064013161
+"HCN4",NA
+"HCRT",-0.3955883250128
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+"HOXB13",0.737038321270366
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+"HOXC4",-0.534379347428681
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+"HOXD11",NA
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+"HOXD8",-1.37991554214009
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+"HPR",0.072375410373379
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+"ORMDL1",-0.0522978957304399
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+"OS9",0.753366814722505
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+"OSBPL8",-0.0728351260284154
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+"OSGEP",-0.0733913167437717
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+"PAX6",-2.23767328366928
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+"PAX8",0.34149952145006
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+"PCED1B",3.04013538782002
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diff --git a/Examples/Coldren_proteomics_DEGs_before_avg.csv b/Examples/Coldren_proteomics_DEGs_before_avg.csv
new file mode 100644
index 0000000..94ffe1d
--- /dev/null
+++ b/Examples/Coldren_proteomics_DEGs_before_avg.csv
@@ -0,0 +1,12402 @@
+"Gene","Log2FC","AveExpr","t","P.Value","adj.P.Val","B","Log2Transformed"
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+"ATF5",NA,NA,NA,NA,NA,NA,FALSE
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+"ATF7IP2",NA,-0.430544942593022,NA,NA,NA,NA,FALSE
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+"ATP10D",NA,NA,NA,NA,NA,NA,FALSE
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+"ATP2B3",NA,NA,NA,NA,NA,NA,FALSE
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+"ATP6V1G1",-0.100431718616881,-0.381624742832203,-0.304006952582267,0.764929427497085,0.956151022825506,-6.08048434318718,FALSE
+"ATP6V1G2",0.106283230628602,-0.351258644981869,0.127071236787655,0.905895794201761,0.988086193158502,-5.24621827431034,FALSE
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+"ATP7B",-0.0512634020810843,-0.41831202248314,-0.167028302342054,0.869659253543413,0.981231122791341,-6.04430302248082,FALSE
+"ATP8A1",1.62322780731982,0.123132272856253,2.74204987177317,0.0163475758682782,0.374873124697629,-3.03565452810394,FALSE
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+"ATP8B2",NA,NA,NA,NA,NA,NA,FALSE
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+"ATP9A",0.561133603038525,0.139737243142866,1.83083155327116,0.0852774757972827,0.606933030832008,-4.59155441239225,FALSE
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diff --git a/Examples/Coldren_transcriptomics_DEGs.csv b/Examples/Coldren_transcriptomics_DEGs.csv
new file mode 100644
index 0000000..688dcb7
--- /dev/null
+++ b/Examples/Coldren_transcriptomics_DEGs.csv
@@ -0,0 +1,19112 @@
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diff --git a/Examples/Coldren_transcriptomics_DEGs_before_avg.csv b/Examples/Coldren_transcriptomics_DEGs_before_avg.csv
new file mode 100644
index 0000000..453be36
--- /dev/null
+++ b/Examples/Coldren_transcriptomics_DEGs_before_avg.csv
@@ -0,0 +1,19112 @@
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--- /dev/null
+++ b/Examples/Fig2/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-ff83b2bd0152a2349f94" style="width:960px;height:500px;"></div>
+</div>
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--- /dev/null
+++ b/Examples/Fig2/DMEA/DMEA_mean_results.csv
@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"MDM inhibitor",2.14666666666667,0.0503322295684717,NA,"GSE12790, GSE31625, Coldren et al",3,3,"GSE12790, GSE31625, Coldren et al",NA
+"sterol demethylase inhibitor",1.38666666666667,0.416813307529082,0.010345636129814,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.119713789502134
+"FLT3 inhibitor",1.37433333333333,0.349322677954543,0.023597478013491,"GSE12790, GSE31625, Coldren et al",3,0,"",0.165340424169999
+"ribonucleotide reductase inhibitor",1.36566666666667,0.373384966667558,0.0235585715825658,"GSE12790, GSE31625, Coldren et al",3,0,"",0.165340424169999
+"RAF inhibitor",1.35833333333333,0.372704082796705,0.0206048682585458,"GSE12790, GSE31625, Coldren et al",3,1,"GSE31625",0.165340424169999
+"PARP inhibitor",1.32666666666667,0.0702376916856849,0.0704098242875693,"GSE12790, GSE31625, Coldren et al",3,0,"",0.291413422411389
+"DNA inhibitor",1.31666666666667,0.257358375292768,0.0744046133712215,"GSE12790, GSE31625, Coldren et al",3,0,"",0.291413422411389
+"thymidylate synthase inhibitor",1.30966666666667,0.60148178138106,0.456873029473853,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.75523908953841
+"Aurora kinase inhibitor",1.30333333333333,0.183393929379719,0.0646135607031861,"GSE12790, GSE31625, Coldren et al",3,0,"",0.290761023164338
+"acetylcholine receptor agonist",1.26,0.147309198626562,0.110483164838256,"GSE12790, GSE31625, Coldren et al",3,0,"",0.357965454075951
+"antioxidant",1.251,0.308501215556762,0.0820746207912007,"GSE12790, GSE31625, Coldren et al",3,0,"",0.302183831094875
+"CC chemokine receptor antagonist",1.23666666666667,0.172433562085034,0.13248906461371,"GSE12790, GSE31625, Coldren et al",3,0,"",0.383838676566381
+"potassium channel blocker",1.22,0.0721110255092798,0.201771775417744,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46695753739535
+"BCL inhibitor",1.172,0.222243110129426,0.211785491605301,"GSE12790, GSE31625, Coldren et al",3,0,"",0.476517356111927
+"serotonin receptor agonist",1.15866666666667,0.367267386699845,0.1594866395273,"GSE12790, GSE31625, Coldren et al",3,0,"",0.43061392672371
+"DNA synthesis inhibitor",1.14966666666667,0.382805868990188,0.172730012687971,"GSE12790, GSE31625, Coldren et al",3,0,"",0.437222844616427
+"phosphatase inhibitor",1.14666666666667,0.140118997046558,0.282499826027809,"GSE12790, GSE31625, Coldren et al",3,0,"",0.544821093053631
+"androgen receptor antagonist",1.143,0.300561141866343,0.21887597483729,"GSE12790, GSE31625, Coldren et al",3,0,"",0.47916091788704
+"protein synthesis inhibitor",1.13933333333333,0.209478718091679,0.247157589313257,"GSE12790, GSE31625, Coldren et al",3,0,"",0.521365104914305
+"DNA alkylating agent",1.136,0.249415316289918,0.266623997127525,"GSE12790, GSE31625, Coldren et al",3,0,"",0.526744969934867
+"HCV inhibitor",1.10733333333333,0.281746931364537,0.294959567007072,"GSE12790, GSE31625, Coldren et al",3,0,"",0.555621509943555
+"FGFR inhibitor",1.09833333333333,0.382764070065796,0.254352052198402,"GSE12790, GSE31625, Coldren et al",3,0,"",0.521365104914305
+"serotonin receptor antagonist",1.07833333333333,0.235283516918065,0.322722675011014,"GSE12790, GSE31625, Coldren et al",3,0,"",0.594103106270275
+"RET tyrosine kinase inhibitor",1.01633333333333,0.108859236325327,0.529293518522628,"GSE12790, GSE31625, Coldren et al",3,0,"",0.808920283025149
+"ATPase inhibitor",0.996333333333333,0.307197547733268,0.50384621764204,"GSE12790, GSE31625, Coldren et al",3,0,"",0.799917370466552
+"JAK inhibitor",0.948333333333333,0.22618208004467,0.64186893984114,"GSE12790, GSE31625, Coldren et al",3,0,"",0.912129546090042
+"CDK inhibitor",0.943666666666667,0.187163921024682,0.676875746286401,"GSE12790, GSE31625, Coldren et al",3,0,"",0.945291990503422
+"acetylcholine receptor antagonist",0.925333333333333,0.350487279845265,0.58120045216875,"GSE12790, GSE31625, Coldren et al",3,0,"",0.871800678253124
+"HMGCR inhibitor",0.921,1.58726588824935,0.0360007018713121,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.182253553223518
+"mTOR inhibitor",0.918333333333333,0.0819410357106458,0.737115606533089,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674
+"adrenergic receptor antagonist",0.847333333333333,0.265846446907483,0.788879740235108,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674
+"cyclooxygenase inhibitor",0.811666666666667,0.361328567004234,0.806363150486619,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674
+"PLK inhibitor",0.79,1.66352036356637,0.000427842408988178,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.0346552351280424
+"dopamine receptor antagonist",0.764666666666667,0.124500334671572,0.941927144670964,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"bromodomain inhibitor",0.639333333333333,1.5341738276132,0.840360448995707,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.972417090980747
+"DNA polymerase inhibitor",0.621,1.36750246800509,0.092406184136918,"GSE12790, GSE31625, Coldren et al",3,0,"",0.325430474569146
+"topoisomerase inhibitor",0.592,1.31931497376479,0.132684974615539,"GSE12790, GSE31625, Coldren et al",3,0,"",0.383838676566381
+"PDGFR tyrosine kinase receptor inhibitor",0.581666666666667,1.08298584170493,0.456548293224534,"GSE12790, GSE31625, Coldren et al",3,0,"",0.75523908953841
+"retinoid receptor agonist",0.542666666666667,1.40226293302409,0.0755516280325824,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.291413422411389
+"PPAR receptor agonist",0.526666666666667,1.5844978173962,0.0410151922447099,"GSE12790, GSE31625, Coldren et al",3,0,"",0.195425327754206
+"microtubule inhibitor",0.521333333333333,1.496323939972,0.0265361174593826,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.165340424169999
+"cytochrome P450 inhibitor",0.465333333333333,1.0017346621403,0.629952169042457,"GSE12790, GSE31625, Coldren et al",3,0,"",0.911180815936412
+"estrogen receptor antagonist",0.451,1.31093592520764,0.257464249340397,"GSE12790, GSE31625, Coldren et al",3,0,"",0.521365104914305
+"opioid receptor agonist",0.447666666666667,1.23980818408871,0.33125873668547,"GSE12790, GSE31625, Coldren et al",3,0,"",0.596265726033847
+"sodium channel blocker",0.421,0.956343557514767,0.738666445881696,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674
+"AP inhibitor",0.409666666666667,0.95569311671338,0.813663493956565,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674
+"tubulin polymerization inhibitor",0.401,1.44817920161836,0.120071116577302,"GSE12790, GSE31625, Coldren et al",3,0,"",0.37406770933698
+"HDAC inhibitor",0.385333333333333,1.40485776266971,0.197916654109267,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46695753739535
+"glycogen synthase kinase inhibitor",0.381,1.03927426601451,0.69858587218184,"GSE12790, GSE31625, Coldren et al",3,0,"",0.959075519436086
+"KIT inhibitor",0.367333333333333,1.11331097781947,0.607825963596335,"GSE12790, GSE31625, Coldren et al",3,0,"",0.895161873660057
+"calcium channel blocker",0.342666666666667,0.976959228081363,0.78433674643619,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674
+"Bcr.Abl kinase inhibitor",0.316666666666667,1.89315433426156,0.004092042160623,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.0784884070929638
+"growth factor receptor inhibitor",0.296333333333333,1.41853104771568,0.158790324475968,"GSE12790, GSE31625, Coldren et al",3,0,"",0.43061392672371
+"proteasome inhibitor",0.276666666666667,1.48288008056395,0.165531633980907,"GSE12790, GSE31625, Coldren et al",3,0,"",0.432518140401725
+"phosphodiesterase inhibitor",0.27,1.02712365370485,0.800031448198042,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674
+"benzodiazepine receptor agonist",0.25,0.742915203774966,0.983930662368058,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"progesterone receptor agonist",0.231666666666667,0.923320276682654,0.894771119370493,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"bacterial DNA gyrase inhibitor",0.225,1.03791955372273,0.759456933181127,"GSE12790, GSE31625, Coldren et al",3,0,"",0.969216808977674
+"Abl kinase inhibitor",0.206666666666667,1.82418018115901,0.0258734640205324,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.165340424169999
+"NFkB pathway inhibitor",0.186333333333333,0.865263158428309,0.963328004423398,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"glucocorticoid receptor agonist",0.102666666666667,0.857242283915891,0.952868910836111,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"histamine receptor antagonist",0.053,0.934038007791974,0.920017368645138,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"MET inhibitor",-0.0723333333333334,1.34172885984216,0.359067235983164,"GSE12790, GSE31625, Coldren et al",3,0,"",0.632270567709484
+"bacterial 50S ribosomal subunit inhibitor",-0.110333333333333,0.912943225690039,0.943805653362881,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"PI3K inhibitor",-0.187666666666667,0.822255637459138,0.97876803772867,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"glutamate receptor antagonist",-0.254333333333333,1.15984496090354,0.513527200793342,"GSE12790, GSE31625, Coldren et al",3,0,"",0.799917370466552
+"adenosine receptor antagonist",-0.28,1.95829007044411,0.00107604150193936,"GSE12790, GSE31625, Coldren et al",3,2,"GSE12790, Coldren et al",0.043579680828544
+"VEGFR inhibitor",-0.325333333333333,0.734679748824842,0.979725457342251,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"p38 MAPK inhibitor",-0.385,0.886869212454689,0.859526714230959,"GSE12790, GSE31625, Coldren et al",3,0,"",0.980586814826869
+"estrogen receptor agonist",-0.478666666666667,1.12144118585565,0.508218109136666,"GSE12790, GSE31625, Coldren et al",3,0,"",0.799917370466552
+"ALK tyrosine kinase receptor inhibitor",-0.526666666666667,1.16834640981745,0.378819080813023,"GSE12790, GSE31625, Coldren et al",3,0,"",0.652858415869253
+"adrenergic receptor agonist",-0.687333333333333,0.0859205058954691,0.96995329091943,"GSE12790, GSE31625, Coldren et al",3,0,"",0.983930662368058
+"HSP inhibitor",-0.723333333333333,1.54778336124063,0.0329098455608673,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.182253553223518
+"AKT inhibitor",-0.723333333333333,1.72653796174116,0.00765536439613635,"GSE12790, GSE31625, Coldren et al",3,2,"GSE31625, Coldren et al",0.103347419347841
+"tyrosine kinase inhibitor",-0.808666666666667,0.188473694008828,0.83801239276031,"GSE12790, GSE31625, Coldren et al",3,0,"",0.972417090980747
+"MEK inhibitor",-0.834666666666667,1.12718114486241,0.104168000000676,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.351567000002281
+"vitamin D receptor agonist",-0.856666666666667,2.2590337167323,0.00215111152782059,"GSE12790, GSE31625, Coldren et al",3,3,"GSE12790, GSE31625, Coldren et al",0.058080011251156
+"DNA methyltransferase inhibitor",-1.166,0.427537132890232,0.196069825511376,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46695753739535
+"CHK inhibitor",-1.26566666666667,0.888924256240842,0.783463278348338,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.969216808977674
+"TGF beta receptor inhibitor",-1.302,0.539344046041115,0.0212004990086226,"GSE12790, GSE31625, Coldren et al",3,1,"GSE31625",0.165340424169999
+"protein tyrosine kinase inhibitor",-1.306,0.544231568360381,0.034864770244826,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.182253553223518
+"src inhibitor",-1.61333333333333,0.415852537966685,0.00484496340080023,"GSE12790, GSE31625, Coldren et al",3,2,"GSE12790, GSE31625",0.0784884070929638
+"EGFR inhibitor",-2.19666666666667,0.161658075373095,NA,"GSE12790, GSE31625, Coldren et al",3,3,"GSE12790, GSE31625, Coldren et al",NA
diff --git a/Examples/Fig2/DMEA/DMEA_results.csv b/Examples/Fig2/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..24b20c1
--- /dev/null
+++ b/Examples/Fig2/DMEA/DMEA_results.csv
@@ -0,0 +1,250 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"GSE12790","Pearson.est","EGFR inhibitor",-0.77405,-2.05,0.00829,1317,0.0725,"WZ8040, PD.153035, ARRY.334543, brigatinib, vandetanib, rociletinib, PD.168393, osimertinib, lapatinib, BMS.690514, neratinib, gefitinib, afatinib, pelitinib, AZD8931, dacomitinib, XL.647, canertinib, erlotinib, icotinib, poziotinib",2.08144546944973,1.13966199342901,TRUE
+"GSE12790","Pearson.est","Abl kinase inhibitor",-0.71056,-1.89,0.0327,1270,0.0717,"metatinib, GZD824, bosutinib, ZM.306416, ponatinib, dasatinib",1.48545224733971,1.1444808443322,TRUE
+"GSE12790","Pearson.est","acetylcholine receptor agonist",0.52038,1.29,0.175,586,0.658,"nefiracetam, nicotine, xanomeline, pilocarpine",0.756961951313706,0.181774106386044,FALSE
+"GSE12790","Pearson.est","acetylcholine receptor antagonist",0.53465,1.33,0.145,42,0.706,"diphemanil",0.838631997765025,0.151195298948196,FALSE
+"GSE12790","Pearson.est","adenosine receptor antagonist",0.78673,1.97,0.00159,287,0.025,"istradefylline, MRS.1220, SCH.58261, sulmazole, PSB.1115",2.79860287567955,1.60205999132796,TRUE
+"GSE12790","Pearson.est","adrenergic receptor agonist",-0.30286,-0.786,0.688,434,0.889,"buphenine, metaraminol, xylazine, isoetharine, lidamidine, oxymetazoline, isoxsuprine, ritodrine, norepinephrine, methyldopa, midodrine, epinephrine, terbutaline, clenbuterol, A61603",0.162411561764489,0.0510982390297863,FALSE
+"GSE12790","Pearson.est","adrenergic receptor antagonist",0.3795,0.919,0.561,226,0.853,"practolol, oxprenolol, dihydroergocristine, metoprolol",0.251037138743839,0.069050968832477,FALSE
+"GSE12790","Pearson.est","AKT inhibitor",0.52174,1.27,0.191,322,0.628,"ONC201, GSK2110183, GDC.0068, MK.2206, uprosertib, palomid.529",0.718966632752272,0.202040356262804,FALSE
+"GSE12790","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.48325,-1.27,0.177,1322,0.567,"AP26113, NVP.TAE684, brigatinib, GW.788388",0.752026733638193,0.246416941107093,FALSE
+"GSE12790","Pearson.est","androgen receptor antagonist",0.34072,0.839,0.663,608,0.933,"enzalutamide, flutamide, nilutamide, RU.58841",0.178486471595227,0.0301183562535,FALSE
+"GSE12790","Pearson.est","antioxidant",0.38019,0.943,0.511,301,0.858,"benfotiamine, trolox",0.291579099865287,0.0665127121512946,FALSE
+"GSE12790","Pearson.est","AP inhibitor",-0.25432,-0.693,0.836,1096,0.922,"LCL.161, birinapant, GDC.0152",0.0777937225609836,0.0352690789463706,FALSE
+"GSE12790","Pearson.est","ATPase inhibitor",0.26548,0.659,0.883,485,0.921,"oligomycin.a, digoxin, rabeprazole, blebbistatin...., evodiamine, NMS.873",0.0540392964224314,0.0357403698031511,FALSE
+"GSE12790","Pearson.est","Aurora kinase inhibitor",0.46741,1.16,0.285,442,0.708,"CCT137690, PHA.680632, AT.9283, SNS.314, ZM.447439, barasertib, barasertib.HQPA, CCT129202, AMG900, aurora.a.inhibitor.i",0.54515513999149,0.149966742310231,FALSE
+"GSE12790","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.20764,-0.569,0.962,299,0.946,"valnemulin, azalomycin.b, radezolid, tilmicosin, josamycin, dirithromycin, azithromycin, tedizolid",0.0168249279621871,0.0241088635982073,FALSE
+"GSE12790","Pearson.est","bacterial DNA gyrase inhibitor",0.28154,0.682,0.806,233,0.932,"nadifloxacin, norfloxacin",0.0936649581949093,0.0305840876460186,FALSE
+"GSE12790","Pearson.est","BCL inhibitor",0.47477,1.16,0.28,493,0.708,"gossypol, TW.37, venetoclax, ABT.737, oridonin",0.552841968657781,0.149966742310231,FALSE
+"GSE12790","Pearson.est","Bcr.Abl kinase inhibitor",-0.70404,-1.86,0.0148,1270,0.0754,"metatinib, GZD824, bosutinib, ponatinib, dasatinib",1.82973828460504,1.12262865413023,TRUE
+"GSE12790","Pearson.est","benzodiazepine receptor agonist",0.34409,0.844,0.656,602,0.949,"zaleplon, ZK.93423, lorazepam, nefiracetam, eprinomectin, temazepam, gamma.aminobutyric.acid, piperazine",0.18309616062434,0.0227337875727074,FALSE
+"GSE12790","Pearson.est","bromodomain inhibitor",0.87421,2.16,0,81,0.00308,"I.BET151, PFI.1, OTX015, JQ1...., bromosporine",Inf,2.51144928349956,TRUE
+"GSE12790","Pearson.est","calcium channel blocker",0.45908,1.12,0.309,449,0.739,"fendiline, tetrandrine, carboxyamidotriazole, SR.33805, mibefradil",0.510041520575165,0.131355561605174,FALSE
+"GSE12790","Pearson.est","CC chemokine receptor antagonist",0.42896,1.05,0.383,518,0.867,"PF.04136309, ZK811752, UNBS.5162, MK.0812",0.416801226031377,0.0619809025237897,FALSE
+"GSE12790","Pearson.est","CDK inhibitor",0.30255,0.741,0.777,162,0.955,"arcyriaflavin.a, NU6027, TG.02, abemaciclib, kenpaullone",0.109578981199086,0.0199966284162537,FALSE
+"GSE12790","Pearson.est","CHK inhibitor",-0.86081,-2.27,0,1341,0.0143,"CHIR.124, AZD7762, LY2603618, SCH.900776, LY2606368",Inf,1.84466396253494,TRUE
+"GSE12790","Pearson.est","cyclooxygenase inhibitor",0.49159,1.21,0.272,217,0.66,"naproxen, meloxicam, tepoxalin, piroxicam, sulfasalazine, pterostilbene, FR.122047",0.565431095965801,0.180456064458131,FALSE
+"GSE12790","Pearson.est","cytochrome P450 inhibitor",0.32499,0.809,0.709,124,0.936,"cobicistat",0.149353764816933,0.0287241512618947,FALSE
+"GSE12790","Pearson.est","DNA alkylating agent",0.35347,0.848,0.652,529,0.967,"dianhydrogalactitol, TH.302, mitomycin.c, melphalan, satraplatin, carmustine, streptozotocin, carboplatin",0.18575240426808,0.0145735259169983,FALSE
+"GSE12790","Pearson.est","DNA inhibitor",0.59916,1.48,0.0774,339,0.474,"pibenzimol, mechlorethamine, chlorambucil, bendamustine, oxaliplatin, tirapazamine, melphalan, primaquine, valrubicin",1.11125903931711,0.324221658325915,FALSE
+"GSE12790","Pearson.est","DNA methyltransferase inhibitor",-0.30427,-0.788,0.724,1288,0.925,"azacitidine, decitabine",0.140261433802853,0.0338582672609674,FALSE
+"GSE12790","Pearson.est","DNA polymerase inhibitor",0.54988,1.36,0.137,60,0.679,"famciclovir, idoxuridine",0.863279432843593,0.168130225719498,FALSE
+"GSE12790","Pearson.est","DNA synthesis inhibitor",0.28992,0.709,0.819,341,0.936,"azodicarbonamide, artemisinin, mitomycin.c, enocitabine, artesunate, CB.10.277",0.0867160982395816,0.0287241512618947,FALSE
+"GSE12790","Pearson.est","dopamine receptor antagonist",0.25736,0.625,0.906,475,0.918,"nemonapride, UH.232...., sertindole, lurasidone, amisulpride, paliperidone, remoxipride",0.0428718023231869,0.0371573187987575,FALSE
+"GSE12790","Pearson.est","estrogen receptor agonist",-0.34653,-0.935,0.499,499,0.974,"equol, estrone, ethinyl.estradiol, estradiol, PPT, erteberel, estradiol.cypionate, levonorgestrel",0.30189945437661,0.0114410431213845,FALSE
+"GSE12790","Pearson.est","estrogen receptor antagonist",0.64005,1.55,0.0616,354,0.421,"fulvestrant, toremifene, danazol",1.21041928783557,0.375717904164332,FALSE
+"GSE12790","Pearson.est","FGFR inhibitor",0.27439,0.675,0.851,389,0.921,"nintedanib, orantinib, regorafenib, dovitinib",0.0700704399154121,0.0357403698031511,FALSE
+"GSE12790","Pearson.est","FLT3 inhibitor",0.39322,0.973,0.47,303,0.852,"TG.101348, TG.02, sorafenib, GTP.14564, pacritinib, quizartinib",0.327902142064283,0.0695604052332999,FALSE
+"GSE12790","Pearson.est","glucocorticoid receptor agonist",0.31067,0.767,0.745,627,0.959,"halcinonide, rimexolone, deflazacort, beclomethasone.dipropionate, prednisolone, fluticasone.propionate, triamcinolone, clobetasol.propionate, difluprednate, halobetasol.propionate, ciclesonide, dexamethasone.acetate, methylprednisolone, flumethasone.pivalate",0.127843727251707,0.0181813928293364,FALSE
+"GSE12790","Pearson.est","glutamate receptor antagonist",0.39642,0.981,0.488,156,0.893,"ACDPP, IEM1754, CPP",0.311580177997289,0.0491485411114536,FALSE
+"GSE12790","Pearson.est","glycogen synthase kinase inhibitor",0.50565,1.23,0.239,463,0.651,"kenpaullone, CHIR.99021, AZD2858, GSK.3.inhibitor.IX",0.621602099051862,0.186419011431808,FALSE
+"GSE12790","Pearson.est","growth factor receptor inhibitor",-0.48176,-1.28,0.207,1082,0.61,"AZD3463, GSK1838705A, GSK1904529A, lestaurtinib, PHA.848125",0.684029654543082,0.214670164989233,FALSE
+"GSE12790","Pearson.est","HCV inhibitor",0.51816,1.27,0.197,403,0.628,"narlaprevir, embelin, mericitabine",0.705533773838407,0.202040356262804,FALSE
+"GSE12790","Pearson.est","HDAC inhibitor",0.55627,1.39,0.134,365,0.657,"PCI.24781, M.344, dacinostat, entinostat, SB.939, RG2833, R306465, scriptaid, RGFP966, givinostat, AR.42, ACY.1215, resminostat, trichostatin.a",0.872895201635192,0.182434630440219,FALSE
+"GSE12790","Pearson.est","histamine receptor antagonist",0.19855,0.495,0.976,351,0.98,"ICI.162846, cyproheptadine, epinastine, lafutidine",0.0105501823333082,0.00877392430750515,FALSE
+"GSE12790","Pearson.est","HMGCR inhibitor",-0.35229,-0.907,0.543,508,0.822,"simvastatin, atorvastatin, mevastatin, lovastatin, pitavastatin, fluvastatin",0.265200170411153,0.0851281824599496,FALSE
+"GSE12790","Pearson.est","HSP inhibitor",-0.71686,-1.9,0.0135,1227,0.0806,"KW.2478, VER.49009, alvespimycin, XL888, PU.H71, SNX.5422, NVP.AUY922, ganetespib, BIIB021",1.86966623150499,1.09366495819491,TRUE
+"GSE12790","Pearson.est","JAK inhibitor",0.28069,0.695,0.839,278,0.935,"TG.101348, TG.02, AT.9283, pacritinib",0.0762380391712997,0.0291883891274822,FALSE
+"GSE12790","Pearson.est","KIT inhibitor",-0.35009,-0.918,0.52,1380,0.894,"cediranib, dasatinib",0.283996656365201,0.0486624812040823,FALSE
+"GSE12790","Pearson.est","MDM inhibitor",0.88974,2.14,0,165,0.00205,"nutlin.3, CGM097, idasanutlin, RITA, AMG.232, serdemetan",Inf,2.68824613894425,TRUE
+"GSE12790","Pearson.est","MEK inhibitor",-0.73195,-1.95,0.00798,1344,0.0977,"PD.0325901, PD.184352, Ro.4987655, AS.703026, TAK.733, cobimetinib, PD.318088, selumetinib, refametinib, AZD8330, trametinib",2.09799710864927,1.01010543628123,TRUE
+"GSE12790","Pearson.est","MET inhibitor",-0.61626,-1.62,0.0528,1352,0.201,"PF.04217903, INC.280, LY2801653",1.27736607746619,0.696803942579511,FALSE
+"GSE12790","Pearson.est","microtubule inhibitor",-0.42511,-1.11,0.329,1042,0.705,"vinflunine, colchicine, estramustine.phosphate, vinblastine, cabazitaxel, podophyllotoxin, cytochalasin.b",0.482804102050026,0.151810883008601,FALSE
+"GSE12790","Pearson.est","mTOR inhibitor",0.39439,0.99,0.453,401,0.904,"WYE.125132, LY303511, PI.103, PKI.179, deforolimus, ku.0063794, WYE.354, palomid.529, torin.2, XL388, torin.1",0.343901797987168,0.0438315695246367,FALSE
+"GSE12790","Pearson.est","NFkB pathway inhibitor",0.32301,0.796,0.728,77,0.935,"tyloxapol, EVP4593",0.137868620686963,0.0291883891274822,FALSE
+"GSE12790","Pearson.est","opioid receptor agonist",-0.35735,-0.968,0.482,1257,0.962,"spiradoline, ADL5859",0.31695296176115,0.0168249279621871,FALSE
+"GSE12790","Pearson.est","p38 MAPK inhibitor",0.25948,0.638,0.892,399,0.924,"SB.242235, skepinone.l",0.0496351456238769,0.0343280287798933,FALSE
+"GSE12790","Pearson.est","PARP inhibitor",0.54017,1.32,0.153,146,0.68,"PJ.34, AZD2461, AG.14361",0.815308569182401,0.167491087293764,FALSE
+"GSE12790","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.24526,-0.665,0.893,1291,0.891,"CP.673451, SU014813, ponatinib, dasatinib",0.0491485411114536,0.0501222959631252,FALSE
+"GSE12790","Pearson.est","phosphatase inhibitor",0.4579,1.14,0.325,366,0.723,"GSK2830371, mycophenolate.mofetil, CID.5458317, AS.1949490",0.488116639021126,0.140861702705469,FALSE
+"GSE12790","Pearson.est","phosphodiesterase inhibitor",-0.34456,-0.916,0.523,1136,0.849,"papaverine, anagrelide, zardaverine, YM.976",0.281498311132726,0.0710923097560473,FALSE
+"GSE12790","Pearson.est","PI3K inhibitor",0.29997,0.76,0.771,239,0.947,"YM.201636, LY303511, CUDC.907, PI.103, PKI.179, BGT226",0.112945621949043,0.0236500209967266,FALSE
+"GSE12790","Pearson.est","PLK inhibitor",-0.43132,-1.13,0.313,1025,0.724,"BI.2536, GW.843682X, NMS.1286937, GSK461364, rigosertib",0.504455662453552,0.140261433802853,FALSE
+"GSE12790","Pearson.est","potassium channel blocker",0.5208,1.3,0.189,151,0.682,"oleoylethanolamide",0.723538195826756,0.166215625343521,FALSE
+"GSE12790","Pearson.est","PPAR receptor agonist",0.62978,1.53,0.0661,227,0.408,"GW.501516, oleoylethanolamide, ciprofibrate, pterostilbene, clofibrate",1.17979854051436,0.38933983691012,FALSE
+"GSE12790","Pearson.est","progesterone receptor agonist",-0.30025,-0.798,0.694,1335,0.95,"levonorgestrel, dienogest",0.158640529545145,0.0222763947111523,FALSE
+"GSE12790","Pearson.est","proteasome inhibitor",0.41098,1.01,0.429,43,0.924,"MG.132, oprozomib",0.367542707815276,0.0343280287798933,FALSE
+"GSE12790","Pearson.est","protein synthesis inhibitor",0.39942,0.998,0.458,167,0.918,"clofoctol, azomycin..2.nitroimidazole., mercaptopurine, anguidine",0.339134521996131,0.0371573187987575,FALSE
+"GSE12790","Pearson.est","protein tyrosine kinase inhibitor",-0.25697,-0.678,0.814,1248,0.907,"AV.412, NVP.TAE226, PP.121",0.0893755951107988,0.0423927129399047,FALSE
+"GSE12790","Pearson.est","RAF inhibitor",0.39016,0.955,0.5,465,0.861,"sorafenib, TAK.632, regorafenib, GDC.0879, PLX.4720",0.301029995663981,0.0649968485463452,FALSE
+"GSE12790","Pearson.est","RET tyrosine kinase inhibitor",0.3907,0.974,0.468,521,0.878,"sorafenib, apatinib, regorafenib, sunitinib, cabozantinib",0.329754146925876,0.0565054840938974,FALSE
+"GSE12790","Pearson.est","retinoid receptor agonist",0.70735,1.74,0.0137,117,0.128,"fenretinide, adapalene, bexarotene, adarotene",1.86327943284359,0.892790030352132,TRUE
+"GSE12790","Pearson.est","ribonucleotide reductase inhibitor",0.37557,0.937,0.511,161,0.844,"pentostatin, cladribine",0.291579099865287,0.073657553374345,FALSE
+"GSE12790","Pearson.est","serotonin receptor agonist",0.29677,0.736,0.789,330,0.941,"aripiprazole, NAN.190",0.10292299679058,0.0264103765727431,FALSE
+"GSE12790","Pearson.est","serotonin receptor antagonist",0.33278,0.825,0.652,412,0.932,"SB.200646, aripiprazole, sertindole, lurasidone, paliperidone",0.18575240426808,0.0305840876460186,FALSE
+"GSE12790","Pearson.est","sodium channel blocker",0.49736,1.24,0.218,305,0.663,"cibenzoline, butamben, benzethonium, triamterene, quinidine, ajmaline",0.661543506395395,0.178486471595227,FALSE
+"GSE12790","Pearson.est","src inhibitor",-0.71939,-1.92,0.013,1262,0.0907,"PP.1, bosutinib, ZM.306416, saracatinib, dasatinib",1.88605664769316,1.0423927129399,TRUE
+"GSE12790","Pearson.est","sterol demethylase inhibitor",0.73519,1.84,0.00315,216,0.0747,"posaconazole, ketoconazole, chlormidazole",2.5016894462104,1.1266793981846,TRUE
+"GSE12790","Pearson.est","TGF beta receptor inhibitor",-0.28251,-0.736,0.797,1403,0.895,"repsox",0.0985416786038876,0.048176964684088,FALSE
+"GSE12790","Pearson.est","thymidylate synthase inhibitor",0.30094,0.729,0.802,222,0.93,"doxifluridine, ftorafur",0.0958256317158365,0.0315170514460649,FALSE
+"GSE12790","Pearson.est","topoisomerase inhibitor",-0.34473,-0.924,0.519,1189,0.937,"fleroxacin, teniposide, topotecan, rubitecan, etoposide, camptothecin, irinotecan, SN.38, exatecan.mesylate",0.284832642151542,0.0282604091122217,FALSE
+"GSE12790","Pearson.est","tubulin polymerization inhibitor",-0.46865,-1.24,0.231,1065,0.569,"indibulin, vindesine, flubendazole, dolastatin.10, verubulin, vinblastine, epothilone.d, nocodazole, podophyllotoxin, BNC105, parbendazole, epothilone.b, docetaxel, paclitaxel",0.636388020107856,0.244887733604929,FALSE
+"GSE12790","Pearson.est","tyrosine kinase inhibitor",-0.33435,-0.885,0.573,1248,0.823,"AV.412, NVP.TAE226, aminopurvalanol.a, PP.121, vandetanib, tivantinib, dasatinib",0.24184537803261,0.0846001647877302,FALSE
+"GSE12790","Pearson.est","VEGFR inhibitor",-0.27844,-0.748,0.795,1183,0.913,"MK.2461, foretinib, RAF265, lucitanib, SU014813, ZM.306416, cediranib, vandetanib, BMS.690514, XL.647",0.0996328713435297,0.039529222465701,FALSE
+"GSE12790","Pearson.est","vitamin D receptor agonist",0.71974,1.74,0.0147,296,0.128,"tacalcitol, alfacalcidol, doxercalciferol, ercalcitriol, paricalcitol",1.83268266525182,0.892790030352132,TRUE
+"GSE31625","Pearson.est","EGFR inhibitor",-0.84531,-2.17,0,1335,0.0275,"CP.724714, rociletinib, brigatinib, PD.153035, BMS.599626, TAK.285, BIBU.1361, WZ8040, AEE788, AST.1306, GW.583340, CUDC.101, vandetanib, BIBX.1382, ARRY.334543, PD.168393, icotinib, erlotinib, BMS.690514, pelitinib, gefitinib, tucatinib, lapatinib, neratinib, XL.647, afatinib, osimertinib, dacomitinib, AZD8931, canertinib, poziotinib",Inf,1.56066730616974,TRUE
+"GSE31625","Pearson.est","Abl kinase inhibitor",0.44648,1.08,0.363,166,0.653,"nilotinib, ponatinib, KW.2449, GZD824, tozasertib, bafetinib",0.440093374963888,0.185086818724926,FALSE
+"GSE31625","Pearson.est","acetylcholine receptor agonist",0.45634,1.1,0.378,556,0.638,"oxiracetam, tremorine, nefiracetam",0.422508200162775,0.195179321278838,FALSE
+"GSE31625","Pearson.est","acetylcholine receptor antagonist",0.29578,0.718,0.809,658,0.894,"methscopolamine, diphemanil, iododexetimide",0.0920514783877277,0.0486624812040823,FALSE
+"GSE31625","Pearson.est","adenosine receptor antagonist",-0.47253,-1.21,0.228,1392,0.705,"MRS.1220, CGS.15943",0.642065152999546,0.151810883008601,FALSE
+"GSE31625","Pearson.est","adrenergic receptor agonist",-0.2496,-0.647,0.859,1121,0.995,"A61603, midodrine, methyldopa, ritodrine, terbutaline, xylazine",0.0660068361687577,0.00217691925427455,FALSE
+"GSE31625","Pearson.est","adrenergic receptor antagonist",0.22766,0.553,0.96,168,0.992,"carvedilol, oxprenolol, atipamezole",0.0177287669604316,0.00348832784582135,FALSE
+"GSE31625","Pearson.est","AKT inhibitor",-0.67949,-1.75,0.0274,1302,0.199,"AZD5363, GSK2110183, CCT128930, uprosertib, GDC.0068, triciribine",1.56224943717961,0.701146923590293,TRUE
+"GSE31625","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.44688,-1.13,0.316,1245,0.815,"NVP.TAE684, AP26113, SB.505124, brigatinib, GW.788388",0.500312917381596,0.0888423912600234,FALSE
+"GSE31625","Pearson.est","androgen receptor antagonist",0.47365,1.15,0.31,765,0.64,"nilutamide, bicalutamide, cyproterone.acetate, enzalutamide, RU.58841, flutamide",0.508638306165727,0.193820026016113,FALSE
+"GSE31625","Pearson.est","antioxidant",0.64967,1.56,0.0371,395,0.399,"trolox, benfotiamine, taurine, mesna",1.43062609038495,0.399027104313252,FALSE
+"GSE31625","Pearson.est","AP inhibitor",0.40862,0.999,0.455,45,0.692,"idronoxil",0.341988603342888,0.159893905543242,FALSE
+"GSE31625","Pearson.est","ATPase inhibitor",0.52532,1.26,0.211,397,0.547,"digoxin, digitoxin, blebbistatin...., digitoxigenin, ouabain, oligomycin.a, evodiamine",0.675717544702307,0.262012673666569,FALSE
+"GSE31625","Pearson.est","Aurora kinase inhibitor",0.51432,1.24,0.22,422,0.56,"AMG900, barasertib, KW.2449, AT.9283, tozasertib, SNS.314, PF.03814735, ENMD.2076, CCT137690, MK.8745, MK.5108, hesperadin, CCT129202",0.657577319177794,0.2518119729938,FALSE
+"GSE31625","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.27431,-0.703,0.801,395,0.99,"valnemulin, radezolid, azalomycin.b, dirithromycin, tilmicosin, azithromycin, tedizolid, josamycin",0.0963674839157623,0.00436480540245009,FALSE
+"GSE31625","Pearson.est","bacterial DNA gyrase inhibitor",-0.36959,-0.963,0.459,1094,1,"sarafloxacin, sparfloxacin, lomefloxacin, trovafloxacin",0.338187314462739,0,FALSE
+"GSE31625","Pearson.est","BCL inhibitor",0.39553,0.956,0.521,604,0.689,"TW.37, venetoclax, gossypol, oridonin, ABT.737",0.283162276700476,0.161780778092374,FALSE
+"GSE31625","Pearson.est","Bcr.Abl kinase inhibitor",0.51193,1.23,0.222,166,0.554,"nilotinib, ponatinib, GZD824, tozasertib, bafetinib",0.653647025549361,0.25649023527157,FALSE
+"GSE31625","Pearson.est","benzodiazepine receptor agonist",-0.229,-0.583,0.915,1389,0.993,"CL.218872",0.0385789059335517,0.00305075150461883,FALSE
+"GSE31625","Pearson.est","bromodomain inhibitor",-0.34455,-0.908,0.55,1138,0.905,"JQ1...., I.BET151, OTX015",0.259637310505756,0.0433514207947967,FALSE
+"GSE31625","Pearson.est","calcium channel blocker",-0.30207,-0.754,0.747,1256,1,"SKF.96365, fendiline, efonidipine.monoethanolate",0.126679398184601,0,FALSE
+"GSE31625","Pearson.est","CC chemokine receptor antagonist",0.52412,1.27,0.18,316,0.591,"navarixin, PF.04136309, UNBS.5162",0.744727494896694,0.228412519118745,FALSE
+"GSE31625","Pearson.est","CDK inhibitor",0.4626,1.11,0.355,131,0.641,"abemaciclib, palbociclib, ribociclib, R547, PHA.848125, NU6027",0.449771646944906,0.193141970481183,FALSE
+"GSE31625","Pearson.est","CHK inhibitor",-0.2304,-0.58,0.929,332,0.963,"SB.218078, SCH.900776, CHIR.124, PF.477736, AZD7762, LY2606368, LY2603618",0.0319842860063582,0.0163737128754655,FALSE
+"GSE31625","Pearson.est","cyclooxygenase inhibitor",0.21335,0.505,0.981,455,0.996,"tepoxalin, suxibuzone, meloxicam, ketoprofen, indoprofen, FR.122047, naproxen",0.0083309926200515,0.00174066157630127,FALSE
+"GSE31625","Pearson.est","cytochrome P450 inhibitor",-0.25746,-0.663,0.854,371,1,"metyrapone, morin, cobicistat, clotrimazole, PF.4981517, itraconazole, eplerenone",0.068542129310995,0,FALSE
+"GSE31625","Pearson.est","DNA alkylating agent",0.5266,1.28,0.199,235,0.645,"mitomycin.c, carboplatin, melphalan, dianhydrogalactitol, TH.302, carmustine",0.701146923590293,0.190440285364732,FALSE
+"GSE31625","Pearson.est","DNA inhibitor",0.59716,1.45,0.0953,240,0.565,"carboplatin, mechlorethamine, melphalan, pibenzimol, chlorambucil, teroxirone, oxaliplatin, carmustine, valrubicin",1.02090709936167,0.247951552180562,FALSE
+"GSE31625","Pearson.est","DNA methyltransferase inhibitor",-0.63003,-1.63,0.0524,1376,0.293,"decitabine, azacitidine, SGI.1027",1.28066871301627,0.533132379645891,FALSE
+"GSE31625","Pearson.est","DNA polymerase inhibitor",-0.38024,-0.957,0.469,1282,0.959,"cidofovir, menadione, cephalomannine",0.328827157284917,0.0181813928293364,FALSE
+"GSE31625","Pearson.est","DNA synthesis inhibitor",0.57445,1.4,0.106,249,0.577,"mitomycin.c, floxuridine, anisomycin, cyclocytidine, azodicarbonamide, nelarabine",0.97469413473523,0.238824186844269,FALSE
+"GSE31625","Pearson.est","dopamine receptor antagonist",0.3309,0.805,0.693,280,0.813,"amisulpride, paliperidone, raclopride, UH.232...., thioproperazine",0.159266765388193,0.0899094544059319,FALSE
+"GSE31625","Pearson.est","estrogen receptor agonist",-0.5073,-1.3,0.196,1380,0.593,"erteberel, levonorgestrel",0.707743928643524,0.226945306635737,FALSE
+"GSE31625","Pearson.est","estrogen receptor antagonist",-0.39305,-1,0.447,1232,0.989,"raloxifene, tamoxifen, clomifene",0.349692476868064,0.0048037084028206,FALSE
+"GSE31625","Pearson.est","FGFR inhibitor",0.58015,1.42,0.111,149,0.582,"erdafitinib, dovitinib, regorafenib, nintedanib",0.954677021213343,0.235077015350112,FALSE
+"GSE31625","Pearson.est","FLT3 inhibitor",0.66301,1.61,0.0414,348,0.348,"TG.101348, dovitinib, ponatinib, KW.2449, tozasertib, sorafenib, ENMD.2076, midostaurin, quizartinib, sunitinib, lestaurtinib",1.3829996588791,0.458420756053419,FALSE
+"GSE31625","Pearson.est","glucocorticoid receptor agonist",-0.33377,-0.865,0.608,997,0.95,"fluocinolone.acetonide, fludroxycortide, halcinonide, dexamethasone.acetate, flumethasone.pivalate, betamethasone, methylprednisolone, desonide, fluorometholone, ciclesonide, flumethasone, hydrocortisone, piretanide, clobetasol.propionate, triamcinolone.acetonide",0.216096420727265,0.0222763947111523,FALSE
+"GSE31625","Pearson.est","glutamate receptor antagonist",-0.15957,-0.424,0.995,1046,0.995,"kynurenic.acid, diazooxonorleucine, IEM1754, LY456236, CGP.37849",0.00217691925427455,0.00217691925427455,FALSE
+"GSE31625","Pearson.est","glycogen synthase kinase inhibitor",-0.30507,-0.778,0.719,439,1,"CHIR.99021, GSK.3.inhibitor.IX, tideglusib, AZD2858, CHIR.98014, kenpaullone, TWS.119, indirubin, LY2090314",0.143271109617117,0,FALSE
+"GSE31625","Pearson.est","growth factor receptor inhibitor",0.28378,0.699,0.839,692,0.899,"PHA.848125, lestaurtinib, AZD3463, danusertib, GSK1838705A",0.0762380391712997,0.0462403082667712,FALSE
+"GSE31625","Pearson.est","HCV inhibitor",0.31913,0.782,0.733,294,0.828,"mericitabine, narlaprevir",0.134896025358872,0.0819696632151199,FALSE
+"GSE31625","Pearson.est","HDAC inhibitor",0.40844,0.986,0.489,570,0.676,"entinostat, resminostat, M.344, scriptaid, RG2833, dacinostat, R306465, givinostat, trichostatin.a, chidamide, PCI.24781, RGFP966, NSC.3852, belinostat, vorinostat, panobinostat, AR.42",0.31069114087638,0.170053304058364,FALSE
+"GSE31625","Pearson.est","histamine receptor antagonist",-0.40601,-1.02,0.435,1284,1,"ranitidine, terfenadine, levocetirizine, chloropyramine, ebastine",0.361510743045363,0,FALSE
+"GSE31625","Pearson.est","HMGCR inhibitor",0.72086,1.72,0.0108,291,0.389,"mevastatin, fluvastatin, atorvastatin, pitavastatin, lovastatin",1.96657624451305,0.410050398674292,FALSE
+"GSE31625","Pearson.est","HSP inhibitor",-0.50469,-1.3,0.181,1126,0.593,"SNX.5422, XL888, guanidine, VER.49009, alvespimycin, KW.2478",0.742321425130815,0.226945306635737,FALSE
+"GSE31625","Pearson.est","JAK inhibitor",0.41465,1.02,0.456,465,0.676,"TG.101348, TG.101209, AT.9283, tozasertib, AZ960, lestaurtinib, TG.02, PRT062070",0.341035157335565,0.170053304058364,FALSE
+"GSE31625","Pearson.est","KIT inhibitor",0.42953,1.03,0.427,311,0.702,"KI.8751, pazopanib, regorafenib, sorafenib, midostaurin, sunitinib",0.369572124974976,0.153662887870195,FALSE
+"GSE31625","Pearson.est","MDM inhibitor",0.90266,2.2,0,48,0.000988,"idasanutlin, nutlin.3, AMG.232, CGM097, serdemetan",Inf,3.00524305541237,TRUE
+"GSE31625","Pearson.est","MEK inhibitor",0.12876,0.304,1,1264,1,"U.0126, arctigenin, PD.98059, PD.198306, MEK162, PD.184352, cobimetinib, BIX.02188, PD.318088, refametinib, nobiletin, PD.0325901, selumetinib, MEK1.2.inhibitor, AS.703026, AZD8330, TAK.733, Ro.4987655, trametinib",0,0,FALSE
+"GSE31625","Pearson.est","MET inhibitor",0.26741,0.64,0.876,418,0.944,"PHA.665752, AMG458, LY2801653",0.0574958938319193,0.025028005701931,FALSE
+"GSE31625","Pearson.est","microtubule inhibitor",0.34468,0.844,0.649,288,0.773,"secnidazole, vinblastine, vinflunine",0.187755303199631,0.111820506081675,FALSE
+"GSE31625","Pearson.est","mTOR inhibitor",0.39094,0.936,0.549,657,0.685,"ku.0063794, XL388, MLN0128, torin.1, AZD2014, LY303511, WAY.600, NVP.BEZ235, deforolimus, voxtalisib, LY3023414, SB.2343, AZD8055, PP242, PI.103, everolimus, WYE.125132, WYE.354, PKI.179, PF.04691502, temsirolimus",0.260427655549908,0.164309428507574,FALSE
+"GSE31625","Pearson.est","NFkB pathway inhibitor",-0.31166,-0.804,0.705,1169,1,"parthenolide...., bindarit, IKK.2.inhibitor.V",0.151810883008601,0,FALSE
+"GSE31625","Pearson.est","opioid receptor agonist",0.40666,0.971,0.498,494,0.682,"trimebutine, salvinorin.a, BW.180C",0.302770657240282,0.166215625343521,FALSE
+"GSE31625","Pearson.est","p38 MAPK inhibitor",-0.35621,-0.937,0.487,1161,0.892,"CMPD.1, talmapimod, SB.239063",0.312471038785366,0.0496351456238769,FALSE
+"GSE31625","Pearson.est","PARP inhibitor",0.53043,1.26,0.213,354,0.547,"talazoparib, AG.14361, PJ.34, olaparib",0.671620396561262,0.262012673666569,FALSE
+"GSE31625","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.52424,1.29,0.208,219,0.664,"KI.8751, pazopanib, dovitinib, regorafenib, ponatinib, nintedanib, axitinib, sorafenib, crenolanib",0.681936665037238,0.177831920631982,FALSE
+"GSE31625","Pearson.est","phosphatase inhibitor",0.53142,1.29,0.168,136,0.664,"bis.maltolato.oxovanadium.IV., GSK2830371, sodium.stibogluconate",0.774690718274137,0.177831920631982,FALSE
+"GSE31625","Pearson.est","phosphodiesterase inhibitor",0.36337,0.869,0.614,114,0.753,"anagrelide, GSK256066",0.211831628858832,0.123205023799299,FALSE
+"GSE31625","Pearson.est","PI3K inhibitor",-0.28147,-0.712,0.783,1240,1,"GSK2126458, TG100.115, TG.100713, CH5132799, alpelisib, PF.05212384, taselisib",0.106238237942057,0,FALSE
+"GSE31625","Pearson.est","PLK inhibitor",0.71022,1.7,0.00636,289,0.302,"volasertib, rigosertib, GSK461364",2.19654288435159,0.519993057042849,FALSE
+"GSE31625","Pearson.est","potassium channel blocker",0.47316,1.16,0.295,476,0.646,"meglitinide, ML133, ibutilide",0.530177984021837,0.189767482004916,FALSE
+"GSE31625","Pearson.est","PPAR receptor agonist",0.56482,1.35,0.144,200,0.659,"GW.501516, clofibrate",0.84163750790475,0.18111458540599,FALSE
+"GSE31625","Pearson.est","progesterone receptor agonist",0.4144,0.986,0.478,261,0.676,"norethindrone, tanaproget, danazol, nomegestrol.acetate",0.320572103387881,0.170053304058364,FALSE
+"GSE31625","Pearson.est","proteasome inhibitor",-0.56749,-1.43,0.136,1091,0.484,"delanzomib, oprozomib, ixazomib.citrate, ONX.0914, carfilzomib",0.866461091629782,0.315154638355588,FALSE
+"GSE31625","Pearson.est","protein synthesis inhibitor",0.43306,1.04,0.425,335,0.706,"mercaptopurine, homoharringtonine, anguidine, brefeldin.a, azomycin..2.nitroimidazole., cycloheximide, harringtonine",0.371611069949688,0.151195298948196,FALSE
+"GSE31625","Pearson.est","protein tyrosine kinase inhibitor",-0.63562,-1.6,0.0597,1335,0.283,"CP.724714, BMS.599626, AV.412",1.22402566887063,0.54821356447571,FALSE
+"GSE31625","Pearson.est","RAF inhibitor",0.69977,1.69,0.0174,277,0.245,"dabrafenib, regorafenib, vemurafenib, TAK.632, sorafenib, RAF265, LGX818, CEP.32496",1.7594507517174,0.610833915635468,TRUE
+"GSE31625","Pearson.est","RET tyrosine kinase inhibitor",0.46899,1.14,0.298,311,0.632,"regorafenib, sorafenib, sunitinib",0.525783735923745,0.199282921717615,FALSE
+"GSE31625","Pearson.est","retinoid receptor agonist",0.37196,0.888,0.606,155,0.742,"fenretinide, bexarotene",0.217527375833714,0.129596094720973,FALSE
+"GSE31625","Pearson.est","ribonucleotide reductase inhibitor",0.62645,1.54,0.0461,344,0.385,"pentostatin, triapine, cladribine, fludarabine, clofarabine, fludarabine.phosphate, cytarabine",1.33629907461035,0.414539270491499,FALSE
+"GSE31625","Pearson.est","serotonin receptor agonist",0.56624,1.34,0.138,158,0.629,"aripiprazole, NAN.190",0.860120913598763,0.201349354554731,FALSE
+"GSE31625","Pearson.est","serotonin receptor antagonist",0.46356,1.12,0.314,346,0.646,"aripiprazole, SB.200646, paliperidone, pirenperone, SB.216641, lerisetron",0.503070351926785,0.189767482004916,FALSE
+"GSE31625","Pearson.est","sodium channel blocker",-0.24824,-0.63,0.878,1320,0.981,"lappaconite, brivaracetam",0.0565054840938974,0.0083309926200515,FALSE
+"GSE31625","Pearson.est","src inhibitor",-0.68109,-1.78,0.0264,1388,0.212,"bosutinib, dasatinib, ZM.306416, saracatinib",1.57839607313017,0.673664139071249,TRUE
+"GSE31625","Pearson.est","sterol demethylase inhibitor",0.42226,1.02,0.449,484,0.676,"chlormidazole, posaconazole, ketoconazole, lanoconazole",0.347753658996677,0.170053304058364,FALSE
+"GSE31625","Pearson.est","TGF beta receptor inhibitor",-0.70132,-1.81,0.00526,1213,0.238,"SB.431542, D.4476, LY2109761, repsox",2.27901425584626,0.623423042943488,TRUE
+"GSE31625","Pearson.est","thymidylate synthase inhibitor",0.51743,1.27,0.202,503,0.591,"ftorafur, trifluridine, carmofur, raltitrexed",0.694648630553376,0.228412519118745,FALSE
+"GSE31625","Pearson.est","topoisomerase inhibitor",0.50673,1.22,0.239,167,0.549,"nemorubicin, TAS.103, amsacrine, idarubicin, teniposide, voreloxin, amonafide, etoposide.phosphate, topotecan",0.621602099051862,0.260427655549908,FALSE
+"GSE31625","Pearson.est","tubulin polymerization inhibitor",0.38582,0.943,0.538,265,0.692,"verubulin, BNC105, taltobulin, combretastatin.A.4, vinblastine, KX2.391, fosbretabulin",0.269217724333611,0.159893905543242,FALSE
+"GSE31625","Pearson.est","tyrosine kinase inhibitor",-0.36966,-0.947,0.47,1311,0.924,"tivantinib, CP.724714, BMS.599626, dasatinib, vandetanib, AV.412",0.327902142064283,0.0343280287798933,FALSE
+"GSE31625","Pearson.est","VEGFR inhibitor",-0.29988,-0.751,0.737,1394,0.993,"AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.132532512140949,0.00305075150461883,FALSE
+"GSE31625","Pearson.est","vitamin D receptor agonist",-0.75652,-1.94,0.0156,1122,0.149,"alfacalcidol, ercalcitriol, paricalcitol, tacalcitol, calcitriol, maxacalcitol",1.80687540164554,0.826813731587726,TRUE
+"Coldren et al","Pearson.est","EGFR inhibitor",-0.82471,-2.37,0,1374,0.00409,"CUDC.101, AEE788, BIBU.1361, PD.153035, TAK.285, vandetanib, BIBX.1382, rociletinib, CP.724714, pelitinib, icotinib, GW.583340, WZ8040, erlotinib, afatinib, ARRY.334543, PD.168393, dacomitinib, gefitinib, XL.647, BMS.690514, neratinib, lapatinib, osimertinib, poziotinib, AZD8931, canertinib, tucatinib",Inf,2.38827669199266,TRUE
+"Coldren et al","Pearson.est","Abl kinase inhibitor",0.60551,1.43,0.0642,225,0.314,"GZD824, KW.2449, ponatinib, tozasertib, flumatinib, nilotinib",1.19246497193115,0.503070351926785,FALSE
+"Coldren et al","Pearson.est","acetylcholine receptor agonist",0.58097,1.39,0.0853,502,0.297,"oxiracetam, xanomeline, pilocarpine, tremorine",1.06905096883248,0.527243550682788,FALSE
+"Coldren et al","Pearson.est","acetylcholine receptor antagonist",0.30262,0.728,0.808,803,0.991,"iododexetimide, methscopolamine, darifenacin",0.0925886392254138,0.00392634551472468,FALSE
+"Coldren et al","Pearson.est","adenosine receptor antagonist",-0.55714,-1.6,0.04,1427,0.178,"MRS.1220, CGS.15943",1.39794000867204,0.749579997691106,TRUE
+"Coldren et al","Pearson.est","adrenergic receptor agonist",-0.22191,-0.629,0.87,318,1,"buphenine, clenbuterol, oxymetazoline, midodrine, lidamidine, ritodrine, isoxsuprine, norepinephrine, isoetharine, terbutaline, metaraminol, epinephrine, A61603, methyldopa, xylazine",0.0604807473813815,0,FALSE
+"Coldren et al","Pearson.est","adrenergic receptor antagonist",0.44946,1.07,0.383,525,0.666,"oxprenolol, idazoxan, atipamezole, carvedilol, naftidrofuryl, vincamine, levobunolol, metoprolol",0.416801226031377,0.176525770829699,FALSE
+"Coldren et al","Pearson.est","AKT inhibitor",-0.58362,-1.69,0.0305,1336,0.209,"triciribine, CCT128930, GSK2110183, uprosertib, GDC.0068",1.51570016065321,0.679853713888946,TRUE
+"Coldren et al","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.34351,0.82,0.725,148,0.932,"DMH1, AZD3463",0.139661993429006,0.0305840876460186,FALSE
+"Coldren et al","Pearson.est","androgen receptor antagonist",0.60467,1.44,0.0778,480,0.34,"nilutamide, RU.58841, bicalutamide, cyproterone.acetate",1.10902040301031,0.468521082957745,FALSE
+"Coldren et al","Pearson.est","antioxidant",0.51222,1.25,0.194,671,0.399,"trolox, mesna, chlorogenic.acid, benfotiamine, taurine",0.712198270069774,0.399027104313252,FALSE
+"Coldren et al","Pearson.est","AP inhibitor",0.381,0.923,0.598,96,0.814,"idronoxil",0.223298816011589,0.0893755951107988,FALSE
+"Coldren et al","Pearson.est","ATPase inhibitor",0.4364,1.07,0.376,323,0.666,"digoxin, evodiamine, blebbistatin...., ouabain, digitoxigenin, digitoxin",0.424812155072339,0.176525770829699,FALSE
+"Coldren et al","Pearson.est","Aurora kinase inhibitor",0.62133,1.51,0.0419,251,0.35,"PF.03814735, AT.9283, barasertib, SNS.314, AMG900, KW.2449, hesperadin, danusertib, ENMD.2076, tozasertib, alisertib, GSK1070916, barasertib.HQPA",1.3777859770337,0.455931955649724,FALSE
+"Coldren et al","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.3898,0.941,0.55,768,0.814,"valnemulin, radezolid, dirithromycin, azalomycin.b, tedizolid, tilmicosin",0.259637310505756,0.0893755951107988,FALSE
+"Coldren et al","Pearson.est","bacterial DNA gyrase inhibitor",0.39298,0.956,0.498,198,0.801,"novobiocin, finafloxacin",0.302770657240282,0.0963674839157623,FALSE
+"Coldren et al","Pearson.est","BCL inhibitor",0.57908,1.4,0.104,235,0.313,"TW.37, gossypol, venetoclax",0.98296666070122,0.504455662453552,FALSE
+"Coldren et al","Pearson.est","Bcr.Abl kinase inhibitor",0.66348,1.58,0.0223,225,0.287,"GZD824, ponatinib, tozasertib, flumatinib, nilotinib",1.65169513695184,0.542118103266008,FALSE
+"Coldren et al","Pearson.est","benzodiazepine receptor agonist",0.20268,0.489,0.989,596,0.999,"eprinomectin, zaleplon, temazepam, ivermectin, ZK.93423",0.0048037084028206,0.000434511774017692,FALSE
+"Coldren et al","Pearson.est","bromodomain inhibitor",0.27519,0.666,0.893,800,0.989,"bromosporine, PFI.1, I.BET.762",0.0491485411114536,0.0048037084028206,FALSE
+"Coldren et al","Pearson.est","calcium channel blocker",0.27812,0.662,0.878,370,0.976,"carboxyamidotriazole, cinnarazine, pranidipine",0.0565054840938974,0.0105501823333082,FALSE
+"Coldren et al","Pearson.est","CC chemokine receptor antagonist",0.5806,1.39,0.107,490,0.297,"UNBS.5162, SB.225002, navarixin, PF.04136309, RS.504393, MK.0812",0.97061622231479,0.527243550682788,FALSE
+"Coldren et al","Pearson.est","CDK inhibitor",0.40186,0.98,0.491,406,0.77,"palbociclib, abemaciclib, AZD5438, PHA.848125, R547, indisulam, ribociclib, kenpaullone, JNJ.7706621, BMS.265246",0.308918507877032,0.113509274827518,FALSE
+"Coldren et al","Pearson.est","CHK inhibitor",-0.33033,-0.947,0.451,476,0.698,"SB.218078, PF.477736, AZD7762, CHIR.124, SCH.900776, LY2606368, LY2603618",0.345823458122039,0.156144577376839,FALSE
+"Coldren et al","Pearson.est","cyclooxygenase inhibitor",0.30161,0.72,0.828,580,0.983,"tepoxalin, piroxicam, indoprofen, suxibuzone, meloxicam, ketoprofen, phenazone, FR.122047",0.0819696632151199,0.00744648216786438,FALSE
+"Coldren et al","Pearson.est","cytochrome P450 inhibitor",0.5096,1.25,0.188,413,0.399,"itraconazole, metyrapone, cobicistat, morin",0.72584215073632,0.399027104313252,FALSE
+"Coldren et al","Pearson.est","DNA alkylating agent",0.52809,1.28,0.17,368,0.398,"melphalan, carboplatin, carmustine, streptozotocin, TH.302, temozolomide, mitomycin.c",0.769551078621726,0.400116927926312,FALSE
+"Coldren et al","Pearson.est","DNA inhibitor",0.41865,1.02,0.434,638,0.738,"melphalan, valrubicin, carboplatin, carmustine, teroxirone, chlorambucil, oxaliplatin, nimorazole, tirapazamine, pibenzimol, mechlorethamine",0.362510270487489,0.131943638176958,FALSE
+"Coldren et al","Pearson.est","DNA methyltransferase inhibitor",-0.36253,-1.08,0.354,1371,0.559,"azacitidine, SGI.1027",0.450996737974212,0.252588192113577,FALSE
+"Coldren et al","Pearson.est","DNA polymerase inhibitor",0.60364,1.46,0.0678,236,0.325,"idoxuridine, trifluridine, foscarnet",1.16877030613294,0.488116639021126,FALSE
+"Coldren et al","Pearson.est","DNA synthesis inhibitor",0.56425,1.34,0.127,373,0.339,"anisomycin, floxuridine, cyclocytidine, CB.10.277, azodicarbonamide, nelarabine, mitomycin.c, artesunate",0.896196279044043,0.469800301796918,FALSE
+"Coldren et al","Pearson.est","dopamine receptor antagonist",0.36056,0.864,0.667,603,0.91,"raclopride, amisulpride, paliperidone, UH.232...., thioproperazine, isofloxythepin, sertindole, domperidone, mesoridazine",0.175874166083451,0.0409586076789064,FALSE
+"Coldren et al","Pearson.est","estrogen receptor agonist",0.32797,0.799,0.729,640,0.928,"estrone, PPT, estradiol, ethinyl.estradiol",0.137272471682025,0.0324520237811379,FALSE
+"Coldren et al","Pearson.est","estrogen receptor antagonist",0.33908,0.803,0.756,506,0.94,"fulvestrant, danazol",0.121478204498793,0.0268721464003014,FALSE
+"Coldren et al","Pearson.est","FGFR inhibitor",0.50189,1.2,0.216,402,0.463,"dovitinib, regorafenib, erdafitinib, nintedanib, MK.2461",0.665546248849069,0.334419008982047,FALSE
+"Coldren et al","Pearson.est","FLT3 inhibitor",0.63527,1.54,0.0347,392,0.326,"dovitinib, KW.2449, ponatinib, TG.101348, ENMD.2076, tozasertib, quizartinib, gilteritinib, midostaurin, sunitinib, lestaurtinib, sorafenib",1.45967052520913,0.486782399932061,FALSE
+"Coldren et al","Pearson.est","glucocorticoid receptor agonist",0.16994,0.406,0.994,629,0.997,"fluticasone.propionate, prednisolone, hydrocortisone, rimexolone, fluocinolone.acetonide, halobetasol.propionate, triamcinolone, prednisolone.acetate",0.00261361560268669,0.00130484168834428,FALSE
+"Coldren et al","Pearson.est","glutamate receptor antagonist",-0.4446,-1.32,0.15,638,0.396,"ACDPP, MTPG, diazooxonorleucine, SIB.1757, tiletamine, IEM1754, JNJ.16259685, CPP, latrepirdine, felbamate, kynurenic.acid, CGP.37849, LY456236",0.823908740944319,0.402304814074488,FALSE
+"Coldren et al","Pearson.est","glycogen synthase kinase inhibitor",0.28675,0.691,0.854,430,0.999,"tideglusib, kenpaullone, TWS.119",0.068542129310995,0.000434511774017692,FALSE
+"Coldren et al","Pearson.est","growth factor receptor inhibitor",0.6058,1.47,0.0558,388,0.332,"PHA.848125, danusertib, AZD3463, GSK1838705A, lestaurtinib",1.25336580106242,0.478861916295964,FALSE
+"Coldren et al","Pearson.est","HCV inhibitor",0.52227,1.27,0.181,207,0.403,"narlaprevir, mericitabine",0.742321425130815,0.39469495385889,FALSE
+"Coldren et al","Pearson.est","HDAC inhibitor",-0.43359,-1.22,0.208,617,0.437,"dacinostat, entinostat, belinostat, resminostat, RG2833, trichostatin.a, scriptaid, RGFP966, AR.42, NSC.3852, R306465, chidamide, givinostat, nexturastat.a, ACY.1215, PCI.24781, vorinostat, M.344, SB.939, panobinostat, pyroxamide, romidepsin, tacedinaline, JNJ.26481585, mocetinostat",0.681936665037238,0.359518563029578,FALSE
+"Coldren et al","Pearson.est","histamine receptor antagonist",0.28671,0.684,0.868,658,0.989,"pheniramine, cimetidine, tiotidine, nizatidine, famotidine, zolantidine, ICI.162846, BF2.649, astemizole",0.0614802748235081,0.0048037084028206,FALSE
+"Coldren et al","Pearson.est","HMGCR inhibitor",0.80486,1.95,0,104,0.0289,"fluvastatin, atorvastatin, mevastatin, pitavastatin",Inf,1.53910215724345,TRUE
+"Coldren et al","Pearson.est","HSP inhibitor",0.42561,1.03,0.429,261,0.735,"SNX.2112, NVP.AUY922, NMS.E973, PU.H71, ganetespib",0.367542707815276,0.133712660915805,FALSE
+"Coldren et al","Pearson.est","JAK inhibitor",0.46895,1.13,0.311,145,0.589,"AT.9283, AZ960, TG.101348, TG.101209, tozasertib",0.507239610973163,0.229884705212898,FALSE
+"Coldren et al","Pearson.est","KIT inhibitor",0.41165,0.99,0.472,765,0.766,"KI.8751, regorafenib, pazopanib, OSI.930, midostaurin, sunitinib, sorafenib, masitinib, cediranib, tandutinib, motesanib, vatalanib, lenvatinib",0.326058001365912,0.115771230367396,FALSE
+"Coldren et al","Pearson.est","MDM inhibitor",0.86919,2.1,0.00124,191,0.00577,"idasanutlin, nutlin.3, serdemetan, AMG.232, CGM097",2.90657831483776,2.23882418684427,TRUE
+"Coldren et al","Pearson.est","MEK inhibitor",-0.29881,-0.858,0.649,427,0.803,"arctigenin, U.0126, PD.0325901, PD.318088, refametinib, nobiletin, AZD8330, Ro.4987655, TAK.733, cobimetinib, PD.184352, PD.198306, AS.703026, MEK162, selumetinib, PD.98059, MEK1.2.inhibitor, trametinib, BIX.02188",0.187755303199631,0.095284454721319,FALSE
+"Coldren et al","Pearson.est","MET inhibitor",0.31428,0.763,0.796,238,0.964,"LY2801653, PHA.665752",0.0990869322623309,0.0159229660971692,FALSE
+"Coldren et al","Pearson.est","microtubule inhibitor",0.74948,1.83,0.00369,249,0.0599,"vinblastine, vinflunine, secnidazole, podophyllotoxin, D.64131, cabazitaxel",2.43297363384094,1.22257317761069,TRUE
+"Coldren et al","Pearson.est","mTOR inhibitor",0.35239,0.829,0.681,693,0.935,"ku.0063794, torin.1, AZD8055, NVP.BEZ235, WYE.354, MLN0128, WAY.600, PKI.179, deforolimus, XL388, LY3023414, AZD2014, palomid.529, PF.04691502, LY303511, voxtalisib, SB.2343",0.166852888087215,0.0291883891274822,FALSE
+"Coldren et al","Pearson.est","NFkB pathway inhibitor",0.23578,0.567,0.948,549,1,"betulinic.acid, bortezomib, BAY.11.7082, EVP4593",0.0231916626619338,0,FALSE
+"Coldren et al","Pearson.est","opioid receptor agonist",0.55941,1.34,0.133,466,0.339,"trimebutine, cebranopadol, salvinorin.a, spiradoline",0.876148359032914,0.469800301796918,FALSE
+"Coldren et al","Pearson.est","p38 MAPK inhibitor",-0.30326,-0.856,0.634,437,0.753,"skepinone.l, SB.242235, VX.702, TAK.715, CMPD.1, SB.239063, talmapimod",0.197910742118267,0.123205023799299,FALSE
+"Coldren et al","Pearson.est","PARP inhibitor",0.57655,1.4,0.0909,602,0.313,"talazoparib, AG.14361, niraparib, olaparib, E7449, PJ.34, AZD2461",1.04143611677803,0.504455662453552,FALSE
+"Coldren et al","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.45968,1.12,0.31,392,0.593,"KI.8751, dovitinib, crenolanib, ponatinib, regorafenib, pazopanib, CP.673451, axitinib, nintedanib, sunitinib, sorafenib",0.508638306165727,0.226945306635737,FALSE
+"Coldren et al","Pearson.est","phosphatase inhibitor",0.42138,1.01,0.445,522,0.743,"GSK2830371, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, CID.5458317, BVT.948",0.351639989019068,0.129011186239425,FALSE
+"Coldren et al","Pearson.est","phosphodiesterase inhibitor",0.35736,0.857,0.671,337,0.903,"GSK256066, anagrelide, YM.976",0.173277479831008,0.0443122496864942,FALSE
+"Coldren et al","Pearson.est","PI3K inhibitor",-0.21553,-0.611,0.927,1367,0.977,"CH5132799, PF.05212384, alpelisib, taselisib",0.0329202658555029,0.0101054362812269,FALSE
+"Coldren et al","Pearson.est","PLK inhibitor",0.73976,1.8,0.00244,382,0.0671,"rigosertib, volasertib, GSK461364, NMS.1286937, BI.2536, HMN.214, GW.843682X",2.61261017366127,1.17327747983101,TRUE
+"Coldren et al","Pearson.est","potassium channel blocker",0.50069,1.2,0.252,726,0.463,"meglitinide, dofetilide, ML133, oleoylethanolamide, ibutilide, mepivacaine",0.598599459218456,0.334419008982047,FALSE
+"Coldren et al","Pearson.est","PPAR receptor agonist",-0.43928,-1.3,0.148,633,0.372,"ciprofibrate, clofibrate, oleoylethanolamide, GW.501516, fenofibrate, S26948, pterostilbene",0.829738284605043,0.429457060118102,FALSE
+"Coldren et al","Pearson.est","progesterone receptor agonist",0.21279,0.507,0.976,772,1,"tanaproget, danazol, nomegestrol.acetate, norethindrone, dienogest",0.0105501823333082,0,FALSE
+"Coldren et al","Pearson.est","proteasome inhibitor",0.52318,1.25,0.177,369,0.399,"MG.132, ixazomib, bortezomib",0.752026733638193,0.399027104313252,FALSE
+"Coldren et al","Pearson.est","protein synthesis inhibitor",0.58007,1.38,0.1,119,0.301,"mercaptopurine, anguidine, homoharringtonine, cycloheximide, brefeldin.a, harringtonine",1,0.521433504406157,FALSE
+"Coldren et al","Pearson.est","protein tyrosine kinase inhibitor",-0.58296,-1.64,0.0233,1354,0.192,"BMS.599626, AV.412, CP.724714",1.63264407897398,0.71669877129645,TRUE
+"Coldren et al","Pearson.est","RAF inhibitor",0.59544,1.43,0.065,526,0.314,"regorafenib, dabrafenib, SB.590885, GDC.0879, RAF265, vemurafenib, sorafenib, TAK.632, LGX818, CEP.32496, PLX.4720",1.18708664335714,0.503070351926785,FALSE
+"Coldren et al","Pearson.est","RET tyrosine kinase inhibitor",0.39031,0.935,0.556,392,0.808,"regorafenib, sunitinib, sorafenib",0.254925208417942,0.0925886392254138,FALSE
+"Coldren et al","Pearson.est","retinoid receptor agonist",-0.3375,-1,0.394,486,0.653,"adarotene, bexarotene, fenretinide, LE.135, tamibarotene, adapalene, AM.580, CD.437",0.404503778174426,0.185086818724926,FALSE
+"Coldren et al","Pearson.est","ribonucleotide reductase inhibitor",0.65753,1.62,0.0286,394,0.252,"clofarabine, cladribine, triapine, fludarabine.phosphate, LY2334737, pentostatin, gemcitabine, fludarabine",1.54363396687096,0.598599459218456,FALSE
+"Coldren et al","Pearson.est","serotonin receptor agonist",0.57158,1.4,0.0896,410,0.313,"aripiprazole, NAN.190, SR.57227A, ipsapirone",1.04769199033787,0.504455662453552,FALSE
+"Coldren et al","Pearson.est","serotonin receptor antagonist",0.5316,1.29,0.149,460,0.395,"aripiprazole, SB.200646, paliperidone, lerisetron, pirenperone, SB.216641, sertindole",0.826813731587726,0.40340290437354,FALSE
+"Coldren et al","Pearson.est","sodium channel blocker",0.27088,0.653,0.89,264,0.968,"butamben, quinidine, ajmaline",0.0506099933550872,0.0141246426916063,FALSE
+"Coldren et al","Pearson.est","src inhibitor",-0.39641,-1.14,0.263,1412,0.51,"ZM.306416, saracatinib",0.580044251510242,0.292429823902064,FALSE
+"Coldren et al","Pearson.est","sterol demethylase inhibitor",0.53593,1.3,0.165,619,0.392,"posaconazole, ketoconazole, chlormidazole, lanoconazole",0.782516055786094,0.406713932979543,FALSE
+"Coldren et al","Pearson.est","TGF beta receptor inhibitor",-0.47357,-1.36,0.14,1362,0.399,"LY2109761, repsox",0.853871964321762,0.399027104313252,FALSE
+"Coldren et al","Pearson.est","thymidylate synthase inhibitor",0.7991,1.93,0,189,0.0228,"trifluridine, raltitrexed, carmofur, ftorafur",Inf,1.64206515299955,TRUE
+"Coldren et al","Pearson.est","topoisomerase inhibitor",0.60559,1.48,0.0596,171,0.341,"idarubicin, topotecan, teniposide, TAS.103, amsacrine, voreloxin, etoposide.phosphate, valrubicin, nemorubicin, daunorubicin, rubitecan, amonafide, doxorubicin",1.22475374025976,0.467245621007502,FALSE
+"Coldren et al","Pearson.est","tubulin polymerization inhibitor",0.62294,1.5,0.0513,295,0.335,"verubulin, vinblastine, taltobulin, BNC105, combretastatin.A.4, vindesine, KX2.391, CYT.997, fosbretabulin, podophyllotoxin, dolastatin.10, vincristine, epothilone.b, albendazole, ABT.751, vinorelbine, docetaxel, plinabulin",1.28988263488818,0.474955192963155,FALSE
+"Coldren et al","Pearson.est","tyrosine kinase inhibitor",-0.20581,-0.594,0.933,1354,0.936,"BMS.599626, AV.412, vandetanib, CP.724714",0.0301183562535,0.0287241512618947,FALSE
+"Coldren et al","Pearson.est","VEGFR inhibitor",0.21469,0.523,0.965,402,1,"KI.8751, dovitinib, regorafenib, ENMD.2076, pazopanib, axitinib, OSI.930, nintedanib, RAF265, sunitinib, sorafenib, MK.2461",0.0154726866562074,0,FALSE
+"Coldren et al","Pearson.est","vitamin D receptor agonist",-0.81854,-2.37,0,1312,0.00409,"tacalcitol, calcitriol, paricalcitol, maxacalcitol",Inf,2.38827669199266,TRUE
diff --git a/Examples/Fig2/DMEA/DMEA_venn_diagram.pdf b/Examples/Fig2/DMEA/DMEA_venn_diagram.pdf
new file mode 100644
index 0000000..099e689
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diff --git a/Examples/Fig2/GSEA/GSEA_correlation_matrix.pdf b/Examples/Fig2/GSEA/GSEA_correlation_matrix.pdf
new file mode 100644
index 0000000..9584315
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diff --git a/Examples/Fig2/GSEA/GSEA_dot_plot.pdf b/Examples/Fig2/GSEA/GSEA_dot_plot.pdf
new file mode 100644
index 0000000..0e3d7b9
Binary files /dev/null and b/Examples/Fig2/GSEA/GSEA_dot_plot.pdf differ
diff --git a/Examples/Fig2/GSEA/GSEA_interactive_network.graph.html b/Examples/Fig2/GSEA/GSEA_interactive_network.graph.html
new file mode 100644
index 0000000..ba20aef
--- /dev/null
+++ b/Examples/Fig2/GSEA/GSEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNVQxNDoxMjoyNSswMTowMDwveG1wOk1ld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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNFQxNDozODo1NyswMTowMDwveG1wOk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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-f7a8f3871a88fc4ed735" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/Fig2/GSEA/GSEA_mean_results.csv b/Examples/Fig2/GSEA/GSEA_mean_results.csv
new file mode 100644
index 0000000..ea6956a
--- /dev/null
+++ b/Examples/Fig2/GSEA/GSEA_mean_results.csv
@@ -0,0 +1,187 @@
+"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",1.89,0.134536240470737,2.00471207292328e-05,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.0037287644556373
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",1.74,0.265141471671257,0.000240278884420519,"GSE12790, GSE31625, Coldren et al",3,0,"",0.0132556357325164
+"KEGG_FOLATE_BIOSYNTHESIS",1.72666666666667,0.485008590989204,0.000285067435107879,"GSE12790, GSE31625, Coldren et al",3,2,"GSE12790, GSE31625",0.0132556357325164
+"KEGG_SULFUR_METABOLISM",1.61,0.36592348927064,0.00246148439985586,"GSE12790, GSE31625, Coldren et al",3,0,"",0.0809457043004935
+"KEGG_RENIN_ANGIOTENSIN_SYSTEM",1.52333333333333,0.325781112609883,0.00571361232076466,"GSE12790, GSE31625, Coldren et al",3,0,"",0.118081321295803
+"KEGG_O_GLYCAN_BIOSYNTHESIS",1.51666666666667,0.090184995056458,0.00649537824712837,"GSE12790, GSE31625, Coldren et al",3,0,"",0.120814035396588
+"KEGG_LEISHMANIA_INFECTION",1.48666666666667,0.231804515342849,0.0123878219177962,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.147394735159805
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",1.47333333333333,0.440945952848343,0.00309397652868314,"GSE12790, GSE31625, Coldren et al",3,0,"",0.0822113763335805
+"KEGG_CIRCADIAN_RHYTHM_MAMMAL",1.46666666666667,0.214553800556721,0.0159709174925683,"GSE12790, GSE31625, Coldren et al",3,0,"",0.152044767501969
+"KEGG_HEMATOPOIETIC_CELL_LINEAGE",1.42666666666667,0.290057465570761,0.00997167355728823,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.142671637050432
+"KEGG_ECM_RECEPTOR_INTERACTION",1.41666666666667,0.370720020140986,0.015729245299059,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.152044767501969
+"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",1.41333333333333,0.205020324195757,0.0264058915738126,"GSE12790, GSE31625, Coldren et al",3,0,"",0.196459833309166
+"KEGG_BLADDER_CANCER",1.35333333333333,0.205993527406405,0.0399686235833409,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.219324697141609
+"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",1.35,0.563471383479232,0.00906084745066521,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.142671637050432
+"KEGG_DORSO_VENTRAL_AXIS_FORMATION",1.34666666666667,0.208166599946613,0.0301444056498553,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.202195220019937
+"KEGG_VIRAL_MYOCARDITIS",1.27533333333333,0.469217788807429,0.0450468667641184,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.239391920517886
+"KEGG_PRIMARY_IMMUNODEFICIENCY",1.266,0.556334431794402,0.0195921888040481,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.164054772359422
+"KEGG_AXON_GUIDANCE",1.25333333333333,0.0351188458428425,0.0799897160275239,"GSE12790, GSE31625, Coldren et al",3,0,"",0.303634432267744
+"KEGG_CELL_ADHESION_MOLECULES_CAMS",1.25333333333333,0.180092568789868,0.104439298993411,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226
+"KEGG_ADHERENS_JUNCTION",1.22333333333333,0.177857620959388,0.110966540335512,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226
+"KEGG_STEROID_BIOSYNTHESIS",1.21866666666667,0.514642918277648,0.0400325385329101,"GSE12790, GSE31625, Coldren et al",3,0,"",0.219324697141609
+"KEGG_BASAL_CELL_CARCINOMA",1.2,0.235159520326097,0.128523489430298,"GSE12790, GSE31625, Coldren et al",3,0,"",0.385570468290895
+"KEGG_PANCREATIC_CANCER",1.17533333333333,0.157306494886045,0.183904383166151,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46857829135485
+"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",1.17,0.158745078663875,0.181661009265945,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46857829135485
+"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",1.16266666666667,0.212417827249347,0.145105371928179,"GSE12790, GSE31625, Coldren et al",3,0,"",0.408933320888505
+"KEGG_THYROID_CANCER",1.15333333333333,0.0585946527708231,0.210692710652901,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293
+"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",1.14433333333333,0.368709009021116,0.167835218682395,"GSE12790, GSE31625, Coldren et al",3,0,"",0.446344530679348
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",1.14433333333333,0.238361769865332,0.208811902161077,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293
+"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",1.143,0.336492199018046,0.203041816453584,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293
+"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",1.13866666666667,0.232562536392544,0.210748692648611,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293
+"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",1.13666666666667,0.0723417813807023,0.198260408890443,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293
+"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",1.136,0.20136533961931,0.237393896128453,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_HEDGEHOG_SIGNALING_PATHWAY",1.12666666666667,0.132790561913614,0.283910492058359,"GSE12790, GSE31625, Coldren et al",3,0,"",0.502927157360522
+"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",1.11666666666667,0.0923760430703401,0.25246493645276,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",1.11533333333333,0.135371094895969,0.268566576128902,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_ENDOCYTOSIS",1.11166666666667,0.31202296923998,0.226691824765323,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311
+"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",1.11,0.0624499799839839,0.274967811759291,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_FOCAL_ADHESION",1.10933333333333,0.356390703208338,0.222775911928715,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.484651487429311
+"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",1.10766666666667,0.290644685713215,0.268619686982773,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_RENAL_CELL_CARCINOMA",1.10666666666667,0.0404145188432737,0.282430833550908,"GSE12790, GSE31625, Coldren et al",3,0,"",0.502927157360522
+"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",1.09866666666667,0.14719148526098,0.314092356527521,"GSE12790, GSE31625, Coldren et al",3,0,"",0.540936836241841
+"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",1.09166666666667,0.478443657428263,0.201069633171426,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293
+"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",1.089,0.386578581920934,0.167979124449217,"GSE12790, GSE31625, Coldren et al",3,0,"",0.446344530679348
+"KEGG_ERBB_SIGNALING_PATHWAY",1.079,0.0981478476585198,0.32900159989543,"GSE12790, GSE31625, Coldren et al",3,0,"",0.556311796186817
+"KEGG_PRION_DISEASES",1.07766666666667,0.437031272717792,0.242728872190082,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.496543815409982
+"KEGG_TIGHT_JUNCTION",1.07766666666667,0.100430738986295,0.364310331895039,"GSE12790, GSE31625, Coldren et al",3,0,"",0.589232362891106
+"KEGG_VEGF_SIGNALING_PATHWAY",1.06766666666667,0.141302276461964,0.334365174443668,"GSE12790, GSE31625, Coldren et al",3,0,"",0.560287589608308
+"KEGG_SMALL_CELL_LUNG_CANCER",1.06433333333333,0.446643407354607,0.192429310181635,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.483673671537623
+"KEGG_MELANOGENESIS",1.05266666666667,0.0916587875401662,0.413063528667972,"GSE12790, GSE31625, Coldren et al",3,0,"",0.64562870867431
+"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",1.04666666666667,0.267644042215278,0.384586270820053,"GSE12790, GSE31625, Coldren et al",3,0,"",0.611393558739572
+"KEGG_LYSOSOME",1.046,0.425500881315186,0.221738213801101,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311
+"KEGG_PATHWAYS_IN_CANCER",1.03966666666667,0.258612322470012,0.395430298344703,"GSE12790, GSE31625, Coldren et al",3,0,"",0.623305385526396
+"KEGG_NON_SMALL_CELL_LUNG_CANCER",1.03566666666667,0.0991682072709461,0.452408828960927,"GSE12790, GSE31625, Coldren et al",3,0,"",0.690739171349311
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",1.01733333333333,0.29438297052196,0.341410918164267,"GSE12790, GSE31625, Coldren et al",3,0,"",0.561968413969502
+"KEGG_GRAFT_VERSUS_HOST_DISEASE",1.00833333333333,1.50716897968786,0.106158461029819,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226
+"KEGG_ACUTE_MYELOID_LEUKEMIA",0.989333333333333,0.113847851685191,0.535177148549286,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424
+"KEGG_NOTCH_SIGNALING_PATHWAY",0.988666666666667,0.16590760480862,0.539485694331938,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424
+"KEGG_DILATED_CARDIOMYOPATHY",0.982333333333333,0.233097261531176,0.519599261253213,"GSE12790, GSE31625, Coldren et al",3,0,"",0.751654207965371
+"KEGG_GNRH_SIGNALING_PATHWAY",0.979333333333333,0.0323934149686836,0.603224772535707,"GSE12790, GSE31625, Coldren et al",3,0,"",0.818125076876376
+"KEGG_JAK_STAT_SIGNALING_PATHWAY",0.939666666666667,0.204808040206759,0.606996024779247,"GSE12790, GSE31625, Coldren et al",3,0,"",0.818125076876376
+"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.932666666666667,0.127844958185035,0.678286709374389,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876120332941918
+"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.905,0.0910659101969557,0.773013983421368,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588
+"KEGG_ENDOMETRIAL_CANCER",0.903,0.182748461005832,0.716771256325571,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702
+"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.895333333333333,0.207695289627216,0.697173771348368,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702
+"KEGG_GLIOMA",0.885666666666667,0.10646282606306,0.791073291064056,"GSE12790, GSE31625, Coldren et al",3,0,"",0.913910758620586
+"KEGG_P53_SIGNALING_PATHWAY",0.877333333333333,0.376988505571898,0.62067694485193,"GSE12790, GSE31625, Coldren et al",3,0,"",0.824613655303279
+"KEGG_ALLOGRAFT_REJECTION",0.875,1.47415229878056,0.0163488997313946,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.152044767501969
+"KEGG_TYPE_I_DIABETES_MELLITUS",0.867666666666667,1.47069586704163,0.00988435123753631,"GSE12790, GSE31625, Coldren et al",3,0,"",0.142671637050432
+"KEGG_WNT_SIGNALING_PATHWAY",0.862,0.175008571218669,0.818207332568072,"GSE12790, GSE31625, Coldren et al",3,0,"",0.929391833681316
+"KEGG_PROSTATE_CANCER",0.842333333333333,0.0884891707122026,0.885626587968505,"GSE12790, GSE31625, Coldren et al",3,0,"",0.96450577624571
+"KEGG_CHRONIC_MYELOID_LEUKEMIA",0.834,0.121786698781107,0.886723052354927,"GSE12790, GSE31625, Coldren et al",3,0,"",0.96450577624571
+"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.62,1.43446854270144,0.0369570461523315,"GSE12790, GSE31625, Coldren et al",3,0,"",0.219324697141609
+"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.601,1.26270067712027,0.136743686694518,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.397411339455942
+"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.58,1.4992331373072,0.0211683577237964,"GSE12790, GSE31625, Coldren et al",3,0,"",0.164054772359422
+"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.571666666666667,1.22724175830736,0.155619125860894,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.425664079560681
+"KEGG_PPAR_SIGNALING_PATHWAY",0.567,1.28177884207846,0.142609882551538,"GSE12790, GSE31625, Coldren et al",3,0,"",0.40808366391671
+"KEGG_GALACTOSE_METABOLISM",0.55,1.49438950745781,0.0304379901105281,"GSE12790, GSE31625, Coldren et al",3,0,"",0.202195220019937
+"KEGG_STARCH_AND_SUCROSE_METABOLISM",0.513666666666667,1.19216623561202,0.256415440665712,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.513333333333333,1.46158589666613,0.0570145053646437,"GSE12790, GSE31625, Coldren et al",3,0,"",0.252821847442748
+"KEGG_ARACHIDONIC_ACID_METABOLISM",0.453333333333333,1.72743547877579,0.0132253486054393,"GSE12790, GSE31625, Coldren et al",3,0,"",0.147394735159805
+"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.453333333333333,1.3539694728218,0.125895112542221,"GSE12790, GSE31625, Coldren et al",3,0,"",0.383876900538577
+"KEGG_PHENYLALANINE_METABOLISM",0.45,1.69858764860692,0.0134715618156811,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.147394735159805
+"KEGG_ASTHMA",0.436666666666667,1.43472413143898,0.108281501405106,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226
+"KEGG_TYPE_II_DIABETES_MELLITUS",0.436666666666667,1.2667412258758,0.259069929470746,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.433,1.16999529913586,0.369478090934058,"GSE12790, GSE31625, Coldren et al",3,0,"",0.592439007877024
+"KEGG_COLORECTAL_CANCER",0.427333333333333,0.880770306795894,0.85391474358544,"GSE12790, GSE31625, Coldren et al",3,0,"",0.943475518927392
+"KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.426666666666667,1.3146228863569,0.208269833147509,"GSE12790, GSE31625, Coldren et al",3,0,"",0.483941442378293
+"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.423333333333333,1.43604781721687,0.094765876168384,"GSE12790, GSE31625, Coldren et al",3,0,"",0.345616724849401
+"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.421666666666667,1.30125260166246,0.263984157613368,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_N_GLYCAN_BIOSYNTHESIS",0.411,1.21937401973308,0.339260323880508,"GSE12790, GSE31625, Coldren et al",3,0,"",0.561968413969502
+"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.410333333333333,0.946689142925667,0.807194324849932,"GSE12790, GSE31625, Coldren et al",3,0,"",0.926778669272144
+"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.406666666666667,1.15752077015202,0.453065477981806,"GSE12790, GSE31625, Coldren et al",3,0,"",0.690739171349311
+"KEGG_AUTOIMMUNE_THYROID_DISEASE",0.393333333333333,1.65714614121185,0.0124274102996564,"GSE12790, GSE31625, Coldren et al",3,1,"GSE12790",0.147394735159805
+"KEGG_CALCIUM_SIGNALING_PATHWAY",0.386,1.0023537299776,0.775267514720685,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588
+"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.382,0.823634020666946,0.944062981274023,"GSE12790, GSE31625, Coldren et al",3,0,"",0.994611226804283
+"KEGG_APOPTOSIS",0.380333333333333,1.0007808617941,0.775572036929403,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588
+"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.377666666666667,0.946910942662156,0.857243885477039,"GSE12790, GSE31625, Coldren et al",3,0,"",0.943475518927392
+"KEGG_ETHER_LIPID_METABOLISM",0.376666666666667,1.42889234490683,0.116087052843398,"GSE12790, GSE31625, Coldren et al",3,0,"",0.359869863814534
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.375,1.12204055185185,0.510884129221171,"GSE12790, GSE31625, Coldren et al",3,0,"",0.751654207965371
+"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.373333333333333,1.42591491097237,0.112745529661901,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226
+"KEGG_MTOR_SIGNALING_PATHWAY",0.372333333333333,1.15660552191892,0.481878888268005,"GSE12790, GSE31625, Coldren et al",3,0,"",0.722818332402008
+"KEGG_FATTY_ACID_METABOLISM",0.366666666666667,1.29616099823029,0.2710663192045,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_VIBRIO_CHOLERAE_INFECTION",0.366666666666667,0.989966329393749,0.779979683108463,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588
+"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.356666666666667,1.47242430478899,0.088068034548536,"GSE12790, GSE31625, Coldren et al",3,0,"",0.327613088520554
+"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.35,1.65429743395799,0.0203926455488642,"GSE12790, GSE31625, Coldren et al",3,0,"",0.164054772359422
+"KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.345333333333333,1.11151128349348,0.612530164941694,"GSE12790, GSE31625, Coldren et al",3,0,"",0.819644681145001
+"KEGG_RETINOL_METABOLISM",0.34,1.59361224894891,0.0466535439311036,"GSE12790, GSE31625, Coldren et al",3,0,"",0.241043310310702
+"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.336,1.14222064418395,0.543307271439058,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424
+"KEGG_MAPK_SIGNALING_PATHWAY",0.311333333333333,0.852192662097799,0.972035943988809,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504
+"KEGG_TYROSINE_METABOLISM",0.311,1.49392201938388,0.0757485972788716,"GSE12790, GSE31625, Coldren et al",3,0,"",0.293525814455628
+"KEGG_MELANOMA",0.305333333333333,1.04215178037239,0.705767002995794,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702
+"KEGG_GLUTATHIONE_METABOLISM",0.295,1.44997413770039,0.155055507277937,"GSE12790, GSE31625, Coldren et al",3,0,"",0.425664079560681
+"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.286666666666667,1.73234907952564,0.0204254493988953,"GSE12790, GSE31625, Coldren et al",3,0,"",0.164054772359422
+"KEGG_LONG_TERM_DEPRESSION",0.283666666666667,0.948827873396083,0.89675507098725,"GSE12790, GSE31625, Coldren et al",3,0,"",0.965651312850048
+"KEGG_GLYCEROLIPID_METABOLISM",0.280333333333333,1.27712189446949,0.271694234906025,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.275666666666667,1.24632914325764,0.429123434671686,"GSE12790, GSE31625, Coldren et al",3,0,"",0.665141323741113
+"KEGG_INSULIN_SIGNALING_PATHWAY",0.269333333333333,0.826704501822346,0.968001466282383,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504
+"KEGG_OLFACTORY_TRANSDUCTION",0.263333333333333,1.00752882506325,0.841300115639517,"GSE12790, GSE31625, Coldren et al",3,0,"",0.937016895263175
+"KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.255666666666667,1.33555094748697,0.2430271129191,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.243,1.67320261773642,0.0331808169251463,"GSE12790, GSE31625, Coldren et al",3,0,"",0.212814894761283
+"KEGG_TASTE_TRANSDUCTION",0.241,0.867140703692313,0.978254231712166,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504
+"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.237,0.935726455755099,0.946484877120205,"GSE12790, GSE31625, Coldren et al",3,0,"",0.994611226804283
+"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.235333333333333,1.10668709820497,0.688506823112401,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702
+"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.231,1.00154530601466,0.824460497620523,"GSE12790, GSE31625, Coldren et al",3,0,"",0.929391833681316
+"KEGG_HISTIDINE_METABOLISM",0.22,1.42042247236518,0.225992905097543,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311
+"KEGG_ALZHEIMERS_DISEASE",0.215,0.853903390320006,0.984906791411828,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999836414226464
+"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.210666666666667,1.65535534956496,0.0487379188084848,"GSE12790, GSE31625, Coldren et al",3,0,"",0.243435273663563
+"KEGG_LONG_TERM_POTENTIATION",0.208666666666667,0.81898371982191,0.995275635269174,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999836414226464
+"KEGG_HOMOLOGOUS_RECOMBINATION",0.204333333333333,0.71244391592134,0.999836414226464,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999836414226464
+"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.141333333333333,1.14306444846007,0.640625546716018,"GSE12790, GSE31625, Coldren et al",3,0,"",0.845080508433897
+"KEGG_LINOLEIC_ACID_METABOLISM",0.13,1.66385095486345,0.049741598604489,"GSE12790, GSE31625, Coldren et al",3,0,"",0.243435273663563
+"KEGG_PROPANOATE_METABOLISM",0.123333333333333,1.56180451188148,0.113640230177712,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226
+"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.098,1.43592896760251,0.22140864513936,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311
+"KEGG_TRYPTOPHAN_METABOLISM",0.0906666666666666,1.26719585437032,0.469481660803075,"GSE12790, GSE31625, Coldren et al",3,0,"",0.709947877311967
+"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.079,1.11892939902391,0.710534584888573,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702
+"KEGG_CELL_CYCLE",0.0143333333333333,1.10123128058248,0.701501369994042,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702
+"KEGG_NON_HOMOLOGOUS_END_JOINING",-0.00366666666666671,1.67707851138023,0.0591112515022086,"GSE12790, GSE31625, Coldren et al",3,0,"",0.25569052975374
+"KEGG_PYRUVATE_METABOLISM",-0.0499999999999999,1.6285883457768,0.0684660160213429,"GSE12790, GSE31625, Coldren et al",3,0,"",0.276840847390647
+"KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.053,1.80878605700066,0.0724248090134894,"GSE12790, GSE31625, Coldren et al",3,0,"",0.286617329287426
+"KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.068,1.20244293003868,0.535507316993309,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424
+"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.0896666666666667,1.32884548888625,0.274239874108206,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_PROTEASOME",-0.118,1.32494226289299,0.256824373349329,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_OTHER_GLYCAN_DEGRADATION",-0.138,1.66089493948293,0.0371314723757607,"GSE12790, GSE31625, Coldren et al",3,0,"",0.219324697141609
+"KEGG_PEROXISOME",-0.152333333333333,1.19721189992972,0.521308563588886,"GSE12790, GSE31625, Coldren et al",3,0,"",0.751654207965371
+"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.154333333333333,1.23740710089014,0.364211432437172,"GSE12790, GSE31625, Coldren et al",3,0,"",0.589232362891106
+"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.167333333333333,1.37186053712953,0.218406812226338,"GSE12790, GSE31625, Coldren et al",3,0,"",0.484651487429311
+"KEGG_BETA_ALANINE_METABOLISM",-0.206,1.10537821581575,0.672238625123212,"GSE12790, GSE31625, Coldren et al",3,0,"",0.874380309600821
+"KEGG_GAP_JUNCTION",-0.206666666666667,1.0753759032698,0.721149680345126,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702
+"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.209666666666667,0.953415089734442,0.942412372032921,"GSE12790, GSE31625, Coldren et al",3,0,"",0.994611226804283
+"KEGG_LYSINE_DEGRADATION",-0.237666666666667,0.768586581546499,0.996110308194897,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999836414226464
+"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.266,1.06526100088194,0.716291182346385,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702
+"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.269,1.50847041734334,0.108118226467449,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226
+"KEGG_PYRIMIDINE_METABOLISM",-0.290666666666667,0.945952077715004,0.903351228150045,"GSE12790, GSE31625, Coldren et al",3,0,"",0.965651312850048
+"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.313333333333333,1.52487157929228,0.0607960428239783,"GSE12790, GSE31625, Coldren et al",3,0,"",0.257001453755908
+"KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.315,1.03396373243939,0.776139368676975,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588
+"KEGG_RIBOFLAVIN_METABOLISM",-0.336333333333333,1.00958919038059,0.762080665220213,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588
+"KEGG_BASE_EXCISION_REPAIR",-0.376333333333333,1.10588983779278,0.590833687529622,"GSE12790, GSE31625, Coldren et al",3,0,"",0.808051955003747
+"KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.389666666666667,0.761196645639833,0.902964607159073,"GSE12790, GSE31625, Coldren et al",3,0,"",0.965651312850048
+"KEGG_SELENOAMINO_ACID_METABOLISM",-0.448666666666667,1.01692936496756,0.684418008860076,"GSE12790, GSE31625, Coldren et al",3,0,"",0.876691768262702
+"KEGG_BUTANOATE_METABOLISM",-0.454,1.10271845908192,0.516133334098852,"GSE12790, GSE31625, Coldren et al",3,0,"",0.751654207965371
+"KEGG_OXIDATIVE_PHOSPHORYLATION",-0.459666666666667,1.00626553818231,0.649637077651426,"GSE12790, GSE31625, Coldren et al",3,0,"",0.850933073543417
+"KEGG_SPLICEOSOME",-0.481666666666667,0.82347697802266,0.821977542438924,"GSE12790, GSE31625, Coldren et al",3,0,"",0.929391833681316
+"KEGG_REGULATION_OF_AUTOPHAGY",-0.506,1.07450267565977,0.541511477158289,"GSE12790, GSE31625, Coldren et al",3,0,"",0.754142929012424
+"KEGG_PROTEIN_EXPORT",-0.55,1.17936423550996,0.25016629122266,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_SPHINGOLIPID_METABOLISM",-0.581333333333333,1.13404820591249,0.312640729071276,"GSE12790, GSE31625, Coldren et al",3,0,"",0.540936836241841
+"KEGG_ABC_TRANSPORTERS",-0.604,1.16105469294086,0.292885843648193,"GSE12790, GSE31625, Coldren et al",3,0,"",0.513931763382678
+"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.625333333333333,1.31791704341864,0.133433956529378,"GSE12790, GSE31625, Coldren et al",3,0,"",0.393947871658163
+"KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.660666666666667,1.33032377011513,0.110285794990918,"GSE12790, GSE31625, Coldren et al",3,0,"",0.358255640899226
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.67,2.25486141481023,5.37007940441247e-05,"GSE12790, GSE31625, Coldren et al",3,2,"GSE12790, Coldren et al",0.0049941738461036
+"KEGG_OOCYTE_MEIOSIS",-0.704333333333333,0.161295794530835,0.975179352858966,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504
+"KEGG_NITROGEN_METABOLISM",-0.721333333333333,1.43064507594768,0.0510428799617149,"GSE12790, GSE31625, Coldren et al",3,0,"",0.243435273663563
+"KEGG_HUNTINGTONS_DISEASE",-0.73,0.109822584198333,0.978319879113805,"GSE12790, GSE31625, Coldren et al",3,0,"",0.999821414918504
+"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.733333333333333,1.4773399518504,0.0299925730022647,"GSE12790, GSE31625, Coldren et al",3,1,"GSE31625",0.202195220019937
+"KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.74,1.83076486748026,0.0400916113054554,"GSE12790, GSE31625, Coldren et al",3,0,"",0.219324697141609
+"KEGG_MISMATCH_REPAIR",-0.825333333333333,0.289891933888015,0.767955796509243,"GSE12790, GSE31625, Coldren et al",3,0,"",0.906726381613588
+"KEGG_PARKINSONS_DISEASE",-0.833333333333333,0.171797361252533,0.84126064431873,"GSE12790, GSE31625, Coldren et al",3,0,"",0.937016895263175
+"KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.897333333333333,0.338919361107231,0.577509183595577,"GSE12790, GSE31625, Coldren et al",3,0,"",0.795679319620572
+"KEGG_DNA_REPLICATION",-0.907,0.584151521439429,0.322948050882043,"GSE12790, GSE31625, Coldren et al",3,0,"",0.551085664807889
+"KEGG_PURINE_METABOLISM",-0.972666666666667,0.306596368754317,0.500569404869013,"GSE12790, GSE31625, Coldren et al",3,0,"",0.744847274445091
+"KEGG_RIBOSOME",-1.094,0.560328475092958,0.183819169330655,"GSE12790, GSE31625, Coldren et al",3,0,"",0.46857829135485
+"KEGG_RNA_DEGRADATION",-1.11533333333333,0.222363066477626,0.245025708596824,"GSE12790, GSE31625, Coldren et al",3,0,"",0.496543815409982
+"KEGG_ONE_CARBON_POOL_BY_FOLATE",-1.244,0.371144176836981,0.0526254256615666,"GSE12790, GSE31625, Coldren et al",3,0,"",0.244708229326285
+"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-1.32933333333333,0.400526320400212,0.0641782944880848,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.265270283884084
+"KEGG_RNA_POLYMERASE",-1.38333333333333,0.150443787951957,0.0570888042612656,"GSE12790, GSE31625, Coldren et al",3,0,"",0.252821847442748
+"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-1.57333333333333,0.383970484976819,0.00261115175162882,"GSE12790, GSE31625, Coldren et al",3,1,"Coldren et al",0.0809457043004935
+"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-1.61666666666667,0.334713808100791,0.00519644916365529,"GSE12790, GSE31625, Coldren et al",3,0,"",0.118081321295803
diff --git a/Examples/Fig2/GSEA/GSEA_results.csv b/Examples/Fig2/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..7c36aa8
--- /dev/null
+++ b/Examples/Fig2/GSEA/GSEA_results.csv
@@ -0,0 +1,559 @@
+"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"GSE12790","Log2FC","KEGG_ABC_TRANSPORTERS",-0.27215,-0.94,0.526,21386,0.864,"ABCG1, ABCD2, ABCA2, ABCA3, ABCC11",0.279014255846261,0.0634862575211067,FALSE
+"GSE12790","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.29499,0.858,0.681,3717,0.783,"CCNA1, PIK3CD, KIT, TCF7L1, TCF7, STAT5A, AKT3, PML, PPARD, PIM1, PIK3CG, KRAS, NRAS, JUP",0.166852888087215,0.106238237942057,FALSE
+"GSE12790","Log2FC","KEGG_ADHERENS_JUNCTION",0.47303,1.38,0.0822,2153,0.29,"SNAI2, RAC2, MET, NECTIN3, TGFBR2, EGFR, PTPRB, LMO7, TCF7L1, TCF7, CTNNA2, FYN, SMAD3, ACTN4",1.08512818245995,0.537602002101044,FALSE
+"GSE12790","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.3243,0.943,0.529,6013,0.692,"IRS2, ACSL5, ACSL4, TNF, TNFRSF1B, NPY, AKT3, PRKAA1, PPARA, CAMKK1, SLC2A4, ADIPOQ, CD36, SLC2A1, PPARGC1A, STAT3, AGRP, NFKBIB, PRKAG2",0.276544327964814,0.159893905543242,FALSE
+"GSE12790","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.38574,-1.34,0.13,18837,0.81,"GPT2, ACY3, ASL, GLS2, GLUL, ASS1, ABAT, CPS1, ALDH5A1, GAD1, ALDH4A1, GLUD2",0.886056647693163,0.0915149811213502,FALSE
+"GSE12790","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.32434,0.956,0.495,3448,0.676,"SGK1, IRS2, PIK3CD, SFN, PRKCA, SCNN1A, PIK3CG, SCNN1G, ATP1B2, KRAS",0.305394801066431,0.170053304058364,FALSE
+"GSE12790","Log2FC","KEGG_ALLOGRAFT_REJECTION",0.61996,1.8,0.0119,3798,0.226,"HLA-G, HLA-A, HLA-B, FAS, TNF, HLA-F, IL5, HLA-C, CD40, HLA-E, HLA-DOB, HLA-DPA1, CD86, HLA-DPB1, IL12A, HLA-DMA, CD28",1.92445303860747,0.645891560852599,TRUE
+"GSE12790","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.46814,1.39,0.0948,2016,0.29,"PLA2G4A, PLA2G1B, PLA2G2F",1.02319166266193,0.537602002101044,FALSE
+"GSE12790","Log2FC","KEGG_ALZHEIMERS_DISEASE",0.23914,0.706,0.887,1303,0.927,"CALML5, IL1B, LPL, COX6B2, APOE, GRIN2D, SNCA, COX7B2, FAS, TNF, BACE2",0.0520763801682736,0.0329202658555029,FALSE
+"GSE12790","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.37994,-1.24,0.211,16095,0.735,"NARS2, DARS2, MARS2, IARS2, EARS2, MTFMT, HARS2, SEPSECS, PARS2, AARS2",0.675717544702307,0.133712660915805,FALSE
+"GSE12790","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.24258,0.707,0.889,7514,0.933,"PGM1, GFPT2, CHIA, GMDS, PGM3, CMAS, GNE, HK3, UGP2, GNPDA2, PGM2, NPL",0.0510982390297863,0.0301183562535,FALSE
+"GSE12790","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.45031,1.3,0.134,2885,0.361,"GPX1, CASP1, GRIN2D, TNF, MAPK13, TNFRSF1B, NEFH, CAT, MAP3K5, PRPH2",0.872895201635192,0.442492798094342,FALSE
+"GSE12790","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.52407,1.52,0.0524,3772,0.244,"CTSS, HLA-G, HLA-A, HLA-B, TAP2, HLA-F, IFNA4, CTSB, TAP1, KIR3DL1, HLA-C, HSPA2, HLA-E, HLA-DOB, CD74, KIR2DL3, HLA-DPA1, KIR2DS3, TAPBP, HLA-DPB1, IFNA7, B2M, HLA-DMA, CALR, KIR2DL4, CD4",1.28066871301627,0.612610173661271,FALSE
+"GSE12790","Log2FC","KEGG_APOPTOSIS",0.36811,1.08,0.331,6072,0.549,"IL1A, BIRC3, TNFSF10, IL1B, IRAK3, PIK3CD, IL1RAP, FAS, TNF, AKT3, IRAK2, MAP3K14, PIK3CG, IL3, TNFRSF10D, MYD88, CASP10, CAPN2, PRKACG, TNFRSF10B, PRKAR2B, CASP8, ENDOD1, BIRC2, CAPN1, IL3RA, PPP3CC, ATM, NGF, PRKACA, PRKAR1B, CHP2",0.480172006224281,0.260427655549908,FALSE
+"GSE12790","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.5947,1.74,0.0164,1142,0.25,"PTGS2, PLA2G4A, AKR1C3, GPX1, CBR1, GPX3, GPX7, ALOX5, CYP4F3, PTGES, ALOX12, PTGIS, PLA2G1B",1.7851561519523,0.602059991327962,FALSE
+"GSE12790","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.22721,0.667,0.917,4727,0.947,"MAOA, NAGS, GATM, ODC1, OTC, ALDH2, PRODH2, P4HA2, SAT1, CKB, GLS, OAT",0.0376306643299789,0.0236500209967266,FALSE
+"GSE12790","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.54299,1.57,0.0342,3146,0.24,"CDH2, ITGA4, ITGB4, ITGA6, ITGA2, GJA1, RYR2, ITGB8, DMD, PKP2, ITGA3, ITGA5, DSC2, TCF7L1, TCF7, CTNNA2, DSP, SLC8A1, DSG2, ACTN4, ITGA1, ITGB1, CACNG7, CACNA2D1, ACTN1, CACNA1S",1.46597389394386,0.619788758288394,TRUE
+"GSE12790","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32599,-1.13,0.274,20210,0.799,"UGT2B17, ALDH9A1, UGT2B4, UGT2B28",0.562249437179612,0.0974532206860086,FALSE
+"GSE12790","Log2FC","KEGG_ASTHMA",0.43694,1.27,0.155,3847,0.351,"TNF, IL5, CD40, HLA-DOB, HLA-DPA1, IL3, HLA-DPB1, HLA-DMA, PRG2",0.809668301829709,0.454692883534176,FALSE
+"GSE12790","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.54382,1.58,0.0302,3798,0.238,"HLA-G, HLA-A, HLA-B, FAS, HLA-F, IL5, IFNA4, HLA-C, CD40, HLA-E, HLA-DOB, HLA-DPA1, CD86, HLA-DPB1, IFNA7, HLA-DMA, CD28",1.51999305704285,0.623423042943488,TRUE
+"GSE12790","Log2FC","KEGG_AXON_GUIDANCE",0.42192,1.22,0.189,4305,0.391,"RAC2, MET, SEMA3A, ROBO3, EFNB2, EPHA2, NTN4, L1CAM, EPHB2, GNAI1, EPHA4, EPHA3, DPYSL2, PAK3, PAK6, NTN3, FYN, ABLIM3, SEMA7A, UNC5D, EPHB6, UNC5B, EFNB3, ITGB1, ABLIM1, SEMA3B, NRP1, UNC5C, FES, EFNB1, KRAS, SEMA4F, NRAS, EPHA1, NFAT5, PLXNA2, CFL2, PLXNC1, PLXNA1",0.723538195826756,0.407823242604133,FALSE
+"GSE12790","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.49512,1.47,0.0595,2072,0.264,"WNT10A, BMP2, WNT16, WNT11, WNT7A, FZD10, SMO, TCF7L1, TCF7, FZD6, WNT5B, FZD2, GLI1, WNT9A",1.22548303427145,0.578396073130169,FALSE
+"GSE12790","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.18577,-0.635,0.966,4116,1,"GTF2F2, TAF4B, STON1, GTF2B, GTF2H1, TBPL1, TAF2, TAF12, GTF2H4, GTF2H3, GTF2I, TAF11, TAF10, TAF7L, TAF5, TBP, TAF4, GTF2E2, GTF2F1, GTF2A1L, TAF13, TAF5L, TAF1, TAF6, GTF2IRD1, TAF7, GTF2A2, TAF9B, TAF1L, GTF2A1, TAF6L, GTF2E1",0.0150228735845067,0,FALSE
+"GSE12790","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.27538,-0.958,0.462,15049,0.883,"POLB, PARP1, POLE2, POLD3, SMUG1, FEN1, PCNA, POLD2, MBD4, APEX2, POLE3, XRCC1, TDG, MPG",0.335358024443874,0.0540392964224314,FALSE
+"GSE12790","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.23359,-0.817,0.715,18988,1,"UPB1, CNDP1, MLYCD, ALDH9A1, ABAT, GAD1",0.145693958198919,0,FALSE
+"GSE12790","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.30988,-1.06,0.349,19657,0.944,"FADS2, BAAT, ACOX3, ACOT4, SCD",0.45717457304082,0.025028005701931,FALSE
+"GSE12790","Log2FC","KEGG_BLADDER_CANCER",0.51899,1.51,0.0492,3707,0.224,"CXCL8, DAPK1, EGFR, VEGFC, CDKN2A, THBS1, MMP1, MMP2, TYMP, MMP9, KRAS, EGF, NRAS",1.30803489723264,0.649751981665837,TRUE
+"GSE12790","Log2FC","KEGG_BUTANOATE_METABOLISM",-0.30894,-1.04,0.354,19867,0.895,"PDHB, PDHA2, HADH, ALDH9A1, ABAT, ACSM3, ALDH5A1, GAD1, BDH2",0.450996737974212,0.048176964684088,FALSE
+"GSE12790","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3178,0.928,0.558,1920,0.703,"RAC2, LYN, PIK3AP1, DAPP1, CARD11, PIK3CD, IFITM1, SYK, AKT3, RASGRP3",0.253365801062421,0.153044674980176,FALSE
+"GSE12790","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.36112,1.05,0.381,3800,0.578,"CALML5, GNA15, RYR2, RYR1, ADRA1B, ADRB2, ADORA2B, EGFR, ADCY7, EDNRB, PTGFR, HRH1, P2RX5, GRIN2D, BST1, CAMK4, HTR7, OXTR, SLC8A1, LHCGR, P2RX3, PRKCA, CHRM5, TRPC1, AVPR1A, PTAFR, PTK2B, PLCZ1, GNAL, CHRM3, P2RX7, PLCE1, CACNA1S, HTR5A, TNNC2, PLCD1, ADCY3, PRKACG, PDGFRB",0.419075024324381,0.238072161579471,FALSE
+"GSE12790","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.26005,0.749,0.822,3146,0.886,"RYR2, COX6B2, COX7B2, SLC9A6, TPM2, MYL2, SLC8A1, TPM4, CACNG7, CACNA2D1, ATP1B2, CACNA1S",0.0851281824599496,0.0525662781129492,FALSE
+"GSE12790","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.4322,1.26,0.166,3090,0.356,"CDH3, CLDN1, CDH2, ITGA4, ITGA6, ICAM2, L1CAM, NECTIN3, ICAM1, CLDN11, CD274, PDCD1LG2, ITGB8, HLA-G, HLA-A, CLDN7, HLA-B, ITGB2, CLDN10, HLA-F, VCAN, CDH5, CLDN6, HLA-C, CD40, HLA-E, HLA-DOB, CNTN1, HLA-DPA1, ITGB1, ITGAM, NLGN1, CD86, HLA-DPB1",0.779891911959945,0.448550002027125,FALSE
+"GSE12790","Log2FC","KEGG_CELL_CYCLE",0.26042,0.764,0.82,3994,0.87,"CCNA1, CDK6, GADD45A, CDKN2A, TGFB2, SFN, CDKN2B, SMC1B, SMAD3, CDC14B, CCNB3, TGFB1, TTK, SKP2, SMC3, TFDP1, CDKN1C, CDC16, ORC3",0.0861861476162833,0.0604807473813815,FALSE
+"GSE12790","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.36207,1.05,0.352,3764,0.578,"CXCL1, RAC2, CXCL8, CXCL11, CXCL6, CXCL5, LYN, CCL5, CXCL16, CCL20, GNAI1, ADCY7, CXCL3, GNB4, ELMO1, PIK3CD, CCR3, NCF1, GNG11, CXCL2, PPBP, AKT3, CCL8, GNGT1, ARRB2, CXCL10, XCL1, PXN, GNG12, PIK3CG, PTK2B, FOXO3, GNG4, DOCK2, CCL18, KRAS, TIAM2, VAV1, STAT1, CCR9, NRAS, ADCY3, PRKACG",0.453457336521869,0.238072161579471,FALSE
+"GSE12790","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.29517,0.858,0.66,4055,0.783,"TGFBR2, CDK6, PIK3CD, CDKN2A, TGFB2, CBLC, STAT5A, AKT3, SMAD3, GAB2, PIK3CG, TGFB1, KRAS, CBLB, NRAS, TGFBR1",0.180456064458131,0.106238237942057,FALSE
+"GSE12790","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.54755,1.61,0.0358,1307,0.256,"BHLHE41, NPAS2",1.44611697335613,0.59176003468815,FALSE
+"GSE12790","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.48203,-1.62,0.0422,14986,1,"ACO1, ACO2, CS, SDHB, PDHA1, MDH2, FH, SUCLG1, PCK2, IDH3B, PCK1, ACLY, IDH3G, IDH2, PDHB, PDHA2, SDHC, PC, OGDHL",1.37468754903833,0,FALSE
+"GSE12790","Log2FC","KEGG_COLORECTAL_CANCER",0.30999,0.903,0.594,2664,0.734,"RAC2, TGFBR2, PIK3CD, TGFB2, TCF7L1, TCF7, AKT3, SMAD3, PIK3CG, TGFB1",0.226213555018806,0.134303940083929,FALSE
+"GSE12790","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.54377,1.59,0.0288,4714,0.268,"C3, PLAU, F3, PLAT, SERPINE1, CFH, C1S, PROC, PLAUR, SERPING1, C1QA, C1R, SERPINF2, CD59, F9, CFI, C9, MBL2, C6, CPB2, F13B, FGG, CFB, C7, C3AR1, TFPI",1.54060751224077,0.571865205971211,FALSE
+"GSE12790","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.47997,1.4,0.0774,4584,0.283,"LDHB, IL4I1, MTAP, CTH, CBS, LDHAL6B, CDO1, DNMT1, MAT2B",1.11125903931711,0.54821356447571,FALSE
+"GSE12790","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.53509,1.56,0.0256,4061,0.231,"INHBA, CXCL1, TNFRSF11B, CXCL8, IL1R2, CXCL11, MET, TSLP, TNFRSF21, IL6, IL18, CXCL6, IL7R, IL1A, CXCL5, BMP2, CCL5, LIF, TNFSF10, IL1B, TGFBR2, CXCL16, CCL20, EGFR, VEGFC, IL15, IL20RA, IL11, IL4R, IL15RA, IL7, CXCL3, CSF2, KDR, OSMR, KIT, IL20RB, IL1RAP, FAS, CCR3, TNF, INHBE, TGFB2, IFNLR1, TNFRSF1B, IL5, IFNA4, CSF2RA, CXCL2, CTF1, PPBP, IL22RA1, CCL8, CXCL10, XCL1, IL24, CD70, TNFRSF25, CD40, TNFRSF14, IFNK, TNFRSF17, IL21, CLCF1, TNFSF15, IL2RG, CSF1R, TGFB1, IFNGR1, IL3, TNFSF11, IL12RB1, IL18R1, IL12A, LTB, IFNE, IFNA7, TNFRSF10D, TNFSF4, CCL18, EGF, TNFRSF8, RELT, CCR9, PDGFRB, TNFSF13B, IL23A, PDGFC, TGFBR1, CCL22, IFNGR2",1.59176003468815,0.636388020107856,TRUE
+"GSE12790","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.52134,1.51,0.0635,2491,0.224,"IL6, IL18, AIM2, CCL5, CASP1, IL1B, PYCARD, IFNA4, CXCL10, DDX58",1.19722627470802,0.649751981665837,FALSE
+"GSE12790","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.4373,1.25,0.169,4450,0.365,"ITGA4, ITGB4, ITGA6, ITGA2, RYR2, ADCY7, ITGB8, DMD, ITGA3, ITGA5, TNF, TPM2, TGFB2, MYL2, SLC8A1, ITGA1, TGFB1, ITGB1, TPM4, CACNG7, CACNA2D1, CACNA1S, SGCB, ADCY3, PRKACG, PLN, MYBPC3, MYH7, ADCY8, LAMA2",0.772113295386326,0.437707135543525,FALSE
+"GSE12790","Log2FC","KEGG_DNA_REPLICATION",-0.20164,-0.683,0.919,4467,1,"PRIM2, RNASEH2B, RNASEH1, RPA1, POLD1, RFC4, RFC3, RFC1, POLD4, RPA4, MCM3, DNA2, PRIM1, RNASEH2A, RPA3, POLE, LIG1, SSBP1, MCM5, POLE4, MCM7, MCM2, RFC5, POLE2, POLD3, RNASEH2C, RPA2, MCM4, FEN1, PCNA, POLD2, POLA1, POLE3, POLA2, RFC2, MCM6",0.0366844886138887,0,FALSE
+"GSE12790","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.53944,1.58,0.0367,4875,0.238,"ETS1, EGFR, ETS2, NOTCH3, ETV7, PIWIL4, KRAS, ETV6, SPIRE1, SOS1, NOTCH4",1.43533393574791,0.623423042943488,TRUE
+"GSE12790","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.39249,1.14,0.263,5142,0.498,"GSTP1, ALDH1A3, ALDH3A1, MAOA, MGST1, ALDH3B1, UGT1A6, ADH1C, FMO3, GSTO1, ADH1B, ADH7, CYP3A4, CYP2E1, CYP2A7, ADH4, CYP3A5, MGST2, CYP2B6, CYP2D6, CYP2C8",0.580044251510242,0.302770657240282,FALSE
+"GSE12790","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.39861,1.17,0.228,2219,0.46,"CDA, UPP1, XDH, DPYD, UGT1A6, TYMP",0.642065152999546,0.337242168318426,FALSE
+"GSE12790","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.6294,1.84,0.00942,2866,0.208,"LAMC2, LAMB3, COL6A2, COL4A1, ITGA4, CD44, ITGB4, ITGA6, COL5A2, COL6A3, ITGA2, HSPG2, COL4A2, SV2A, COL6A1, LAMA4, COL4A6, LAMB1, ITGB8, COL1A2, ITGA3, LAMA3, ITGA5, FN1, THBS1, LAMC1, COMP, THBS2, ITGA1, TNXB, ITGB1, TNC",2.02594909720712,0.681936665037238,TRUE
+"GSE12790","Log2FC","KEGG_ENDOCYTOSIS",0.26906,0.765,0.8,2564,0.875,"MET, ADRB2, EHD2, EGFR, RAB31, ARAP3, SH3KBP1, DNM1, HLA-G, KDR, HLA-A, KIT, PLD1, HLA-B, HLA-F, CBLC, ARRB2, HLA-C, HSPA2, HLA-E, ASAP1, IL2RG, CSF1R, CHMP1B",0.0969100130080564,0.0579919469776868,FALSE
+"GSE12790","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.28432,0.835,0.705,5328,0.813,"EGFR, PIK3CD, TCF7L1, TCF7, CTNNA2, AKT3, PIK3CG, FOXO3, KRAS, EGF, NRAS, MLH1, SOS1, CTNNA3, MYC, CDH1, CTNNB1",0.151810883008601,0.0899094544059319,FALSE
+"GSE12790","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.46544,1.35,0.115,1897,0.312,"CXCL1, CXCL8, MET, LYN, CCL5, PTPRZ1, EGFR, MAPK13, HBEGF, TCIRG1, MAP3K14",0.939302159646388,0.505845405981557,FALSE
+"GSE12790","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.33451,0.967,0.493,3707,0.667,"EREG, TGFA, EGFR, PIK3CD, NRG4, PAK3, PAK6, HBEGF, CBLC, STAT5A, AKT3, PRKCA, NRG1, AREG, PIK3CG, KRAS, EGF, CBLB, NRAS",0.30715308072277,0.175874166083451,FALSE
+"GSE12790","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.44868,1.29,0.128,2016,0.345,"PLA2G4A, AGPS, PLA2G7, PLD1, PLA2G1B, LPCAT2, PLA2G2F",0.892790030352132,0.462180904926726,FALSE
+"GSE12790","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38434,1.12,0.293,7056,0.511,"ACSL5, ACSL4, EHHADH, ACADVL, ADH1C, ALDH2, ADH1B, ACADL, ADH7, CYP4A11, ACADS, ADH4, ACAT2, ECI2, ALDH3A2, GCDH, ACAT1, ALDH1B1, ACADM, HADHB",0.533132379645891,0.291579099865287,FALSE
+"GSE12790","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.39577,1.15,0.257,3707,0.484,"PLA2G4A, RAC2, LYN, CSF2, PIK3CD, PLA2G1B, TNF, MAPK13, IL5, FYN, SYK, AKT3, PLA2G2F, PRKCA, GAB2, PIK3CG, IL3, KRAS, VAV1, NRAS",0.590066876668705,0.315154638355588,FALSE
+"GSE12790","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.35861,1.04,0.375,4326,0.592,"PLA2G4A, RAC2, LYN, MYO10, DNM1, MARCKS, PIK3CD, PLD1, NCF1, SYK, AKT3, PRKCA, GAB2, ASAP1, PIK3CG, ARPC1B, PLA2G4D, DOCK2, FCGR1A, VAV1, DNM3, CFL2, PLPP2, WASF2",0.425968732272281,0.22767829327708,FALSE
+"GSE12790","Log2FC","KEGG_FOCAL_ADHESION",0.52221,1.52,0.0496,2589,0.244,"LAMC2, CAV1, LAMB3, CAV2, RAC2, COL6A2, COL4A1, MET, ITGA4, ITGB4, ITGA6, COL5A2, COL6A3, ITGA2, BIRC3, COL4A2, COL6A1, LAMA4, EGFR, VEGFC, COL4A6, LAMB1, ITGB8, COL1A2, ITGA3, KDR, PIK3CD, MYL9, LAMA3, PARVB, ITGA5, PAK3, PAK6, FN1, THBS1, FLNC, MYL2, FYN, AKT3, LAMC1, PXN, PRKCA, RASGRF1, ACTN4, COMP, THBS2, ITGA1, MYLPF, PIK3CG, TNXB",1.3045183235098,0.612610173661271,TRUE
+"GSE12790","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.58041,1.73,0.0106,10,0.234,"ALPP",1.97469413473523,0.630784142589857,TRUE
+"GSE12790","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.40475,1.18,0.218,2988,0.448,"AKR1B1, AKR1B10, GMDS, MTMR2, ALDOC",0.661543506395395,0.348721986001856,FALSE
+"GSE12790","Log2FC","KEGG_GALACTOSE_METABOLISM",0.44744,1.29,0.132,1356,0.345,"AKR1B1, MGAM, PGM1",0.87942606879415,0.462180904926726,FALSE
+"GSE12790","Log2FC","KEGG_GAP_JUNCTION",0.34726,1.01,0.434,4660,0.622,"TUBB6, GJA1, EGFR, GNAI1, ADCY7, LPAR1, TUBA4A, TUBB2B, PRKCA, TUBA8, KRAS, EGF, TUBB2A, MAPK7, NRAS, ADCY3, PRKACG, PDGFRB, PDGFC, TUBB4A, ADCY8, TUBB1, ITPR3, SOS1, HTR2C",0.362510270487489,0.206209615309181,FALSE
+"GSE12790","Log2FC","KEGG_GLIOMA",0.32463,0.94,0.553,3800,0.685,"CALML5, TGFA, CDK6, EGFR, PIK3CD, CDKN2A, AKT3, PRKCA, PIK3CG, KRAS, EGF, NRAS, PDGFRB",0.257274868695302,0.164309428507574,FALSE
+"GSE12790","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.43695,1.28,0.152,3581,0.348,"GSTP1, GPX1, GPX3, GPX7, MGST1, ODC1, ANPEP, GSTO1, OPLAH, GPX2, GCLM",0.818156412055227,0.458420756053419,FALSE
+"GSE12790","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.4909,1.42,0.0801,4280,0.285,"AKR1B1, LIPG, GPAT3, LPL, AGPAT4, DGKG, LIPF, CEL, GK2, ALDH2, DGKA, MBOAT2, DGAT1, LIPC, PLPP2",1.09636748391576,0.54515513999149,FALSE
+"GSE12790","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32024,0.918,0.563,4321,0.717,"PLA2G4A, GPAT3, AGPAT4, DGKG, PLD1, PLA2G1B, LPCAT2, PLA2G2F, PCYT1B, PEMT, DGKA, MBOAT2, ADPRM, PLPP2, LPCAT4",0.249491605148654,0.1444808443322,FALSE
+"GSE12790","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.36899,1.08,0.325,4472,0.549,"PSAT1, MAOA, GATM, CTH, CBS, DMGDH, PSPH, SRR, SHMT1",0.488116639021126,0.260427655549908,FALSE
+"GSE12790","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.41046,1.22,0.172,3236,0.391,"LDHB, ALDH1A3, ALDH3A1, GALM, ENO2, PGM1, ALDH3B1, ADH1C, LDHAL6B, ALDH2, ALDOC, ADH1B, BPGM",0.764471553092451,0.407823242604133,FALSE
+"GSE12790","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.50716,1.46,0.0595,2026,0.269,"CHST11, CHST3, CSGALNACT1, CHSY3, DSE",1.22548303427145,0.570247719997592,FALSE
+"GSE12790","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.33931,1,0.409,1611,0.637,"HS6ST2, NDST3, EXT1, HS3ST1",0.388276691992658,0.19586056766465,FALSE
+"GSE12790","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.49142,1.44,0.0697,8295,0.272,"B3GNT7, B4GALT4, FUT8, CHST4, CHST6, B3GNT2, B4GALT1, B4GALT2, CHST2",1.15676722190199,0.565431095965801,FALSE
+"GSE12790","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.43467,1.27,0.15,795,0.351,"HYAL4, HPSE",0.823908740944319,0.454692883534176,FALSE
+"GSE12790","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.29865,0.873,0.652,2339,0.775,"ST8SIA1, ST6GALNAC5",0.18575240426808,0.11069829749369,FALSE
+"GSE12790","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.52019,1.51,0.05,2667,0.224,"GBGT1, ST8SIA1, FUT2",1.30102999566398,0.649751981665837,FALSE
+"GSE12790","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.68553,2,0.00242,2932,0.113,"GCNT2, B3GNT5, B3GNT3, FUT3, ST8SIA1, B3GALT2, FUT4, ST3GAL6, FUT7, FUT2, B4GALT4",2.61618463401957,0.94692155651658,TRUE
+"GSE12790","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.38134,-1.33,0.131,17084,0.733,"PIGU, PIGK, PIGC, DPM2, PIGW, PIGO, PIGH, PIGM, PIGN",0.882728704344236,0.134896025358872,FALSE
+"GSE12790","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.28107,-0.968,0.477,14986,0.934,"ACO1, ACO2, CS, MDH2, MTHFD1L, MTHFD1, GRHPR, PGP",0.321481620959886,0.0296531237699066,FALSE
+"GSE12790","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34603,0.996,0.464,4534,0.639,"CALML5, PLA2G4A, MMP14, EGFR, ADCY7, PLD1, PLA2G1B, MAPK13, HBEGF, MMP2, PLA2G2F, PRKCA, PTK2B, CACNA1S, KRAS, MAPK7, NRAS, MAP3K4, ADCY3, PRKACG, GNRH1, GNRHR, ADCY8, MAP2K7, ITPR3, SOS1",0.333482019445119,0.1944991418416,FALSE
+"GSE12790","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.68865,2.01,0,3798,0.311,"IL6, IL1A, IL1B, HLA-G, HLA-A, HLA-B, FAS, TNF, HLA-F, KIR3DL1, HLA-C, HLA-E, HLA-DOB, KIR2DL3, HLA-DPA1, CD86, HLA-DPB1, HLA-DMA, CD28",Inf,0.507239610973163,FALSE
+"GSE12790","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36655,1.05,0.373,2072,0.578,"WNT10A, BMP2, WNT16, WNT11, WNT7A, SMO, WNT5B, GLI1, WNT9A",0.428291168191312,0.238072161579471,FALSE
+"GSE12790","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.59027,1.72,0.00948,3420,0.222,"IL1R2, IL6, ITGA4, IL7R, IL1A, CD44, ITGA6, ITGA2, IL1B, IL11, IL4R, IL7, CSF2, CD37, ITGA3, KIT, ITGA5, TNF, IL5, CSF2RA, CD3E, CD59, ITGA1, CD1D, CSF1R, ANPEP, ITGAM, IL3, CD1C, CD14, FCGR1A",2.02319166266193,0.653647025549361,TRUE
+"GSE12790","Log2FC","KEGG_HISTIDINE_METABOLISM",0.36482,1.06,0.351,2923,0.577,"ALDH1A3, ALDH3A1, MAOA, ALDH3B1, ALDH2, TRMT11",0.454692883534176,0.238824186844269,FALSE
+"GSE12790","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",-0.18202,-0.615,0.981,6140,1,"RPA1, TOP3A, RAD51, RAD52, POLD1, XRCC2, BLM, POLD4, RPA4, RAD51D, RPA3, SSBP1, MUS81, XRCC3, RAD51B, EME1, POLD3, RPA2, RAD54L, POLD2, NBN, TOP3B, RAD54B, RAD50, RAD51C",0.0083309926200515,0,FALSE
+"GSE12790","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.22928,-0.769,0.779,18203,1,"NDUFA6, POLR2L, COX5B, NDUFB3, COX8A, PPID, ITPR1, NDUFC1, HTT, NDUFB2, NDUFA8, NDUFV3, POLR2G, TP53, NDUFB1, DCTN4, UQCR10, COX4I1, AP2S1, SIN3A, NDUFB10, NDUFS2, NDUFS3, COX8C, COX6B1, SLC25A6, NDUFAB1, SLC25A31, POLR2I, SDHC, NDUFA1, UQCRB, NDUFA3, CLTCL1, PLCB1, CREB3L4, COX7B, PLCB4, DNALI1",0.108462542327436,0,FALSE
+"GSE12790","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.49279,1.44,0.0822,4155,0.272,"IL6, ITGA4, ITGB4, ITGA6, ITGA2, RYR2, ITGB8, DMD, ITGA3, ITGA5, TNF, TPM2, TGFB2, MYL2, SLC8A1, PRKAA1, ITGA1, TGFB1, ITGB1, TPM4, CACNG7, CACNA2D1, CACNA1S, SGCB, ACE, MYBPC3, MYH7",1.08512818245995,0.565431095965801,FALSE
+"GSE12790","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.29586,-1.04,0.362,18853,0.895,"PIP5K1C, PIP4K2C, PI4KB, PLCD4, PLCG1, IPPK, IPMK, INPPL1, PIK3C2B, ALDH6A1, PIP4K2A, CDIPT, PI4KA, PLCB1, INPP5J, PLCB4",0.441291429466834,0.048176964684088,FALSE
+"GSE12790","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.17801,0.51,0.998,6013,0.995,"CALML5, IRS2, PYGL, GYS2, PIK3CD, FOXO1, CBLC, AKT3, PRKAA1, PIK3CG, KRAS, PRKCI, CBLB, NRAS, PRKACG, SLC2A4, MKNK1, SOS1, PRKAR2B, CALML3, SOCS2, PPARGC1A, INSR, TRIP10, SORBS1, SOCS1, SHC3, PRKACA, CBL, PRKCZ, PRKAR1B, PRKAG2",0.000869458712628891,0.00217691925427455,FALSE
+"GSE12790","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.47361,1.38,0.0898,6391,0.29,"IL6, ITGA4, IL15, IL15RA, IL5, MAP3K14, CD40, HLA-DOB, TNFRSF17, HLA-DPA1, TGFB1, CD86, HLA-DPB1, HLA-DMA, CCR9, CD28, TNFSF13B, CCL25, IL2, LTBR, CCL27, TNFSF13, IL4, TNFRSF13C, MADCAM1, CD80, AICDA",1.0467236633327,0.537602002101044,FALSE
+"GSE12790","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.38763,1.12,0.267,6171,0.511,"TSLP, IL6, IL7R, LIF, IL15, IL20RA, IL11, IL4R, IL15RA, IL7, CSF2, OSMR, SPRY2, PIK3CD, IL20RB, IL13RA2, IFNLR1, IL5, CBLC, IFNA4, CSF2RA, CTF1, IL22RA1, STAT5A, AKT3, IL24, IFNK, IL21, CLCF1, IL2RG, PIM1, PIK3CG, IFNGR1, IL3, IL12RB1, IL12A, IFNE, IFNA7, STAT1, CBLB, IL23A, IFNGR2, STAT6, SPRY3, SOS1, IL2, CCND2, MYC, SOCS2, IL3RA, STAT3, IL4, SOCS1, IL10RB, IFNL2, TYK2, CBL, EPO, PRL, STAT5B, GH2, CNTF, SOCS5, IL9, IL12RB2",0.573488738635425,0.291579099865287,FALSE
+"GSE12790","Log2FC","KEGG_LEISHMANIA_INFECTION",0.59547,1.7,0.0212,3656,0.227,"PTGS2, C3, NCF2, ITGA4, IL1A, IL1B, TLR2, ITGB2, TNF, TGFB2, MAPK13, NCF1, HLA-DOB, HLA-DPA1, TGFB1, IFNGR1, ITGB1, ITGAM, CYBA, HLA-DPB1, IL12A, MYD88, FCGR1A, HLA-DMA, STAT1",1.67366413907125,0.643974142806877,TRUE
+"GSE12790","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.4872,1.41,0.0867,3079,0.283,"NCF2, RAC2, CLDN1, ITGA4, MSN, GNAI1, ICAM1, CLDN11, PIK3CD, CLDN7, MYL9, ITGB2, CLDN10, MAPK13, CTNNA2, MYL2, NCF1, CDH5, CLDN6, EZR, MMP2, RASSF5, PXN, PRKCA, THY1, ACTN4, MMP9, RAPGEF4, MYLPF, PIK3CG, TXK, PTK2B, ITGB1, ITGAM, CYBA, ACTN1",1.06198090252379,0.54821356447571,FALSE
+"GSE12790","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.46665,1.35,0.102,3050,0.312,"EHHADH, ALDH2, YOD1",0.991399828238082,0.505845405981557,FALSE
+"GSE12790","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.35684,1.03,0.385,2016,0.606,"PLA2G4A, PLA2G1B, AKR1B10, PLA2G2F",0.414539270491499,0.217527375833714,FALSE
+"GSE12790","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.32644,0.948,0.526,2099,0.688,"PLA2G4A, LYN, RYR1, GNAI1, PLA2G1B, PLA2G2F, PRKCA",0.279014255846261,0.162411561764489,FALSE
+"GSE12790","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23108,0.677,0.917,6072,0.945,"CALML5, GRIN2D, CAMK4, PRKCA, KRAS, NRAS, PRKACG, GRIA2, ADCY8, RPS6KA1, ITPR3, CALML3, GRIN2B, PPP3CC, GRM5, PRKACA, PLCB3, CHP2",0.0376306643299789,0.0245681914907371,FALSE
+"GSE12790","Log2FC","KEGG_LYSINE_DEGRADATION",-0.17683,-0.599,0.978,18742,1,"NSD1, EHMT1, SETD1B, BBOX1, HADH, ALDH9A1, SETD7, OGDHL",0.00966114521239857,0,FALSE
+"GSE12790","Log2FC","KEGG_LYSOSOME",0.23973,0.697,0.881,1603,0.931,"LAMP3, CTSV, ACP5, CTSS, LAPTM5, CTSH, AP1S3, TCIRG1, LIPA, CTSB",0.0550240915879521,0.0310503190186574,FALSE
+"GSE12790","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.28678,0.835,0.696,4562,0.813,"PLA2G4A, RAC2, IL1R2, PTPRR, IL1A, IL1B, TGFBR2, EGFR, DUSP10, RRAS2, GADD45A, FAS, PLA2G1B, TNF, FGF11, TGFB2, RELB, MAPK13, FLNC, AKT3, MEF2C, ARRB2, MAP4K4, MAP3K14, RASGRP3, PLA2G2F, PRKCA, HSPA2, RASGRF1, NF1, GNG12, DUSP7, MAP3K5, FGF21, BDNF, DUSP6, TGFB1, RRAS, CACNG7, CACNA2D1, FGF2, RASA2, CACNA1S, CD14, KRAS, EGF, NFKB2, MAPK7, NRAS, MAP3K4, PRKACG, PDGFRB, MKNK1, TGFBR1, MAP3K8, NTRK2, FGF20, NTF3, RPS6KA1, FGF3, MAP2K7, SOS1, DUSP9",0.157390760389438,0.0899094544059319,FALSE
+"GSE12790","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.52661,1.52,0.0517,4382,0.244,"PAX6, HHEX, NKX2-2, SLC2A2, FOXA3, BHLHA15, NR5A2, HNF4G, NEUROG3, PDX1",1.28650945690606,0.612610173661271,FALSE
+"GSE12790","Log2FC","KEGG_MELANOGENESIS",0.39019,1.15,0.262,4327,0.484,"CALML5, WNT10A, GNAI1, WNT16, ADCY7, EDNRB, WNT11, KIT, WNT7A, FZD10, TCF7L1, TCF7, FZD6, WNT5B, FZD2, WNT9A, PRKCA, MITF, MC1R, KRAS, NRAS, ADCY3, PRKACG, FZD7, WNT7B, ADCY8, WNT2B, WNT6",0.581698708680255,0.315154638355588,FALSE
+"GSE12790","Log2FC","KEGG_MELANOMA",0.26559,0.775,0.803,4422,0.881,"MET, CDK6, EGFR, PIK3CD, CDKN2A, FGF11, AKT3, FGF21, PIK3CG, MITF, FGF2, KRAS, EGF, NRAS, PDGFRB, PDGFC, FGF20, FGF3",0.095284454721319,0.0550240915879521,FALSE
+"GSE12790","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43549,1.28,0.143,5142,0.348,"GSTP1, AKR1C3, ALDH1A3, ALDH3A1, AKR1C4, MGST1, ALDH3B1, UGT1A6, ADH1C, CYP2S1, GSTO1, AKR1C1, ADH1B, CYP1B1, ADH7, CYP3A4, CYP2E1, DHDH, ADH4, CYP3A5, MGST2, CYP2B6, CYP2C8",0.844663962534938,0.458420756053419,FALSE
+"GSE12790","Log2FC","KEGG_MISMATCH_REPAIR",-0.18866,-0.652,0.961,4182,1,"MLH1, MSH2, RPA1, MSH6, POLD1, RFC4, RFC3, RFC1, POLD4, RPA4, RPA3, MSH3, LIG1, SSBP1, EXO1, RFC5, POLD3, RPA2, MLH3, PCNA, POLD2, RFC2",0.0172766123314547,0,FALSE
+"GSE12790","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",-0.27974,-0.963,0.466,19079,0.907,"EIF4EBP1, RPS6KB1, TSC1, RPS6KA6, MLST8, TSC2, AKT1, ULK3, ULK1, MAPK3, CAB39L, PIK3R1, PIK3R3",0.33161408331,0.0423927129399047,FALSE
+"GSE12790","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.44783,1.29,0.16,4534,0.345,"RAC2, LCK, ICAM2, TNFSF10, ICAM1, HLA-G, CSF2, PIK3CD, HLA-A, HLA-B, ITGB2, FAS, TNF, MICB, FYN, IFNA4, SYK, KIR3DL1, HLA-C, PRKCA, HLA-E, PIK3CG, KIR2DL3, KIR2DS3, PTK2B, IFNGR1, IFNA7, TNFRSF10D, KRAS, VAV1, KIR2DL4, SH2D1B, NRAS, ULBP2, NFAT5, IFNGR2, LCP2, TNFRSF10B, SOS1",0.795880017344075,0.462180904926726,FALSE
+"GSE12790","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.33595,0.974,0.475,5611,0.665,"GABRP, HTR1D, PTH2R, PRSS3, TAAR8, ADRA1B, ADRB2, ADORA2B, PRSS2, GLP2R, EDNRB, PTGFR, HRH1, CHRNB1, P2RX5, NR3C1, GRIN2D, LPAR3, LPAR1, P2RY1, S1PR1, GABRA3, FPR1, HTR7, GRM3, OXTR, PTGER4, PTGER2, GLRA1, GALR2, LHCGR, TAAR1, P2RX3, P2RY6, CHRM5, CHRM4, AVPR1A, S1PR5, PTAFR, CHRM3, CHRNA5, GRIN3A, P2RX7, MTNR1B, P2RY14, MC1R, GABRQ, HTR5A, GPR156, CNR1, HTR1E, FPR2, CHRNA9, F2RL1, GRIA2, FPR3, GRIK5, GRM2, TSPO, P2RY8, GNRHR, OPRD1, MAS1, NPFFR2, ADRA1D, GABRG1, C3AR1, HTR2C, GABRB1, GABRA4, CCKAR, GHRHR, GABRG2, CALCRL, GRIN2B, TBXA2R, TACR3, ADCYAP1R1, GALR3, GRM5, TSHB, TAAR5, NTSR2, MC4R, GLRB",0.323306390375133,0.177178354696895,FALSE
+"GSE12790","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.22721,0.662,0.928,4534,0.938,"CALML5, IRS2, ARHGDIB, IRAK3, PIK3CD, CAMK4, MAPK13, SH2B3, AKT3, IRAK2, MAP3K5, BDNF, PIK3CG, FOXO3, KRAS, MAPK7, NRAS, NTRK2, NTF3, RPS6KA1, MAP2K7, SOS1",0.0324520237811379,0.0277971616209356,FALSE
+"GSE12790","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.37466,1.08,0.335,926,0.549,"NT5E, NMNAT2, BST1",0.474955192963155,0.260427655549908,FALSE
+"GSE12790","Log2FC","KEGG_NITROGEN_METABOLISM",-0.37926,-1.35,0.126,19632,0.915,"GLS2, GLUL, CPS1, GLUD2, CA8, CA5B, CA12",0.899629454882437,0.0385789059335517,FALSE
+"GSE12790","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.68398,2,0.00121,1786,0.113,"CXCL1, CARD6, TNFAIP3, CXCL8, IL6, IL18, CCL5, BIRC3, CASP1, IL1B, NLRP1, PYCARD, NLRP3, TNF, MAPK13, CXCL2, CCL8, CASP5",2.91721462968355,0.94692155651658,TRUE
+"GSE12790","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",0.32493,0.941,0.545,7933,0.689,"POLL, DNTT, POLM, DCLRE1C, LIG4, XRCC6, PRKDC",0.263603497723358,0.161780778092374,FALSE
+"GSE12790","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.33567,0.973,0.487,3707,0.661,"TGFA, CDK6, EGFR, PIK3CD, CDKN2A, RASSF5, AKT3, PRKCA, PIK3CG, FOXO3, KRAS, EGF, NRAS",0.312471038785366,0.17979854051436,FALSE
+"GSE12790","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.27442,0.806,0.762,2612,0.845,"MAML2, HES5, JAG1, NOTCH3, DTX3L, DTX4",0.1180450286604,0.0731432910503077,FALSE
+"GSE12790","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.16843,-0.605,0.982,5460,1,"CUL4B, DDB2, RAD23A, GTF2H1, ERCC5, RPA1, GTF2H5, POLD1, ERCC6, GTF2H4, CDK7, RFC4, RFC3, GTF2H3, RFC1, POLD4, RPA4, XPA, RPA3, RAD23B, ERCC3, POLE, LIG1, ERCC1, POLE4, RBX1, RFC5, XPC, POLE2, POLD3, RPA2, ERCC2, MNAT1, PCNA, POLD2, CETN2, POLE3, ERCC4, ERCC8, DDB1, RFC2, CCNH",0.00788851221305034,0,FALSE
+"GSE12790","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.29674,-0.997,0.417,17629,0.936,"MGAT2, MAN1B1, DOLPP1, DAD1, DPM2, MGAT3, MGAT4A, MAN2A2, ALG1, DPM3, MAN1C1",0.379863945026242,0.0287241512618947,FALSE
+"GSE12790","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.3346,0.966,0.502,6189,0.663,"CALML5, OR5K1, CLCA4, OR2B3, OR1D5, OR10H3, ARRB2, OR5J2, OR3A2, OR5P3, OR1J2, CLCA1, GUCY2D, GNAL, OR5I1, OR2L13, OR5P2, OR10H1, OR51B5, ADCY3, PRKACG, OR2M4, OR51B2, OR11A1, OR3A3, OR1F1, OR2B2, OR8B8, OR13C4, GUCA1B, OR51I1, OR7C1, CALML3, OR1Q1, PDE1C, OR10J1, PRKACA, OR10A3, OR10A5, OR2W1, OR7E24",0.299296282854981,0.178486471595227,FALSE
+"GSE12790","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.2506,-0.852,0.545,16339,0.98,"MTHFD1L, SHMT2, MTHFD1, MTHFR, MTR, ATIC, MTFMT, DHFR",0.263603497723358,0.00877392430750515,FALSE
+"GSE12790","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.1902,-0.657,0.965,18189,1,"PPP2CA, SKP1, ESPL1, ITPR1, CDC23, CALM1, ANAPC11, ADCY2, PPP2R5B, RPS6KA6, ADCY1, CUL1, CAMK2D, ANAPC13, CALML6, ANAPC2, ADCY9, MAPK3, ADCY6, PPP2R5A, PGR, AR",0.0154726866562074,0,FALSE
+"GSE12790","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.37146,-1.26,0.193,18528,0.754,"AGA, MANBA, MAN2C1, NEU4",0.714442690992226,0.122628654130226,FALSE
+"GSE12790","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.3734,-1.26,0.183,17021,0.754,"NDUFS1, ATP6V1B1, NDUFA2, NDUFB8, PPA2, ATP6V1C2, NDUFA10, ATP6V1B2, ATP6V0C, ATP6V1G1, UQCRQ, COX6C, NDUFA6, COX5B, NDUFB3, COX8A, ATP6V0A1, ATP6V1A, ATP6V0B, NDUFC1, COX17, NDUFB2, NDUFA8, NDUFV3, NDUFB1, UQCR10, COX4I1, NDUFB10, NDUFS2, NDUFS3, COX8C, COX6B1, COX11, NDUFAB1, ATP6V1H, SDHC, NDUFA1, UQCRB, ATP6V0D1, NDUFA3, ATP6V0E2, ATP6AP1, COX7B",0.737548910269571,0.122628654130226,FALSE
+"GSE12790","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.52024,1.51,0.0517,2541,0.224,"GALNT12, GALNT14, ST6GALNAC1, GALNT5, GCNT3, GALNT3, C1GALT1, GALNT2, GALNTL6",1.28650945690606,0.649751981665837,FALSE
+"GSE12790","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.44723,1.29,0.15,1613,0.345,"IGFBP3, SERPINB5, SERPINE1, CDK6, GADD45A, CDKN2A, FAS, SFN, THBS1, PMAIP1",0.823908740944319,0.462180904926726,FALSE
+"GSE12790","Log2FC","KEGG_PANCREATIC_CANCER",0.44612,1.29,0.14,3709,0.345,"RAC2, TGFA, TGFBR2, CDK6, EGFR, VEGFC, PIK3CD, PLD1, CDKN2A, TGFB2, AKT3, SMAD3, RALBP1, PIK3CG, TGFB1, KRAS, EGF, STAT1, BRCA2",0.853871964321762,0.462180904926726,FALSE
+"GSE12790","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.56738,1.63,0.0292,1460,0.261,"BCAT1, VNN1, DPYD",1.53461714855158,0.583359492661719,FALSE
+"GSE12790","Log2FC","KEGG_PARKINSONS_DISEASE",-0.26569,-0.896,0.561,17898,0.922,"UQCRQ, COX6C, NDUFA6, UBA1, COX5B, NDUFB3, COX8A, PPID, SLC18A2, NDUFC1, NDUFB2, NDUFA8, NDUFV3, SLC6A3, NDUFB1, UQCR10, COX4I1, NDUFB10, NDUFS2, NDUFS3, COX8C, COX6B1, SLC25A6, NDUFAB1, SLC25A31, SDHC, NDUFA1, UQCRB, NDUFA3, TH, COX7B",0.251037138743839,0.0352690789463706,FALSE
+"GSE12790","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.48941,1.42,0.0981,3464,0.285,"CLDN1, TUBB6, HCLS1, TUBA4A, FYN, EZR, TUBB2B, PRKCA, TUBA8, ITGB1, ARPC1B, LY96, CD14, TUBB2A",1.00833099262005,0.54515513999149,FALSE
+"GSE12790","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.45269,1.33,0.12,2240,0.335,"PTGS2, LAMC2, GSTP1, LAMB3, PPARG, RAC2, CXCL8, ETS1, COL4A1, MET, IL6, CCNA1, WNT10A, TGFA, BMP2, ITGA6, ITGA2, BIRC3, COL4A2, TGFBR2, CDK6, DAPK1, LAMA4, EGFR, VEGFC, COL4A6, LAMB1, WNT16, WNT11, ITGA3, PIK3CD, KIT, PLD1, LAMA3, CDKN2A, FOXO1, WNT7A, FAS, FZD10, FN1, FGF11, SMO, TGFB2, CDKN2B, TCF7L1, TCF7, CTNNA2, FZD6, CBLC, WNT5B, MMP1, CSF2RA, MMP2, STAT5A, RASSF5, AKT3, SMAD3, FZD2, PML, PPARD, GLI1, LAMC1, WNT9A, PRKCA, RALBP1, EPAS1, MMP9",0.920818753952375,0.474955192963155,FALSE
+"GSE12790","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.34766,1.01,0.419,1596,0.622,"AKR1B1, UGT1A6",0.377785977033705,0.206209615309181,FALSE
+"GSE12790","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.26351,0.767,0.79,7015,0.886,"PGM1, DERA, ALDOC, TALDO1, PGD, RBKS, TKTL2, PRPS2, ALDOB, PGM2",0.102372908709559,0.0525662781129492,FALSE
+"GSE12790","Log2FC","KEGG_PEROXISOME",-0.24932,-0.857,0.612,19000,0.998,"CRAT, MLYCD, PEX1, PEX19, IDH2, ABCD1, BAAT, PEX16, DECR2, ACOX3, EPHX2, PEX11B, PMVK, ABCD2, CROT, ACSL1, ACOX2",0.213248577854439,0.000869458712628891,FALSE
+"GSE12790","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.57311,1.67,0.0206,1512,0.227,"ALDH1A3, ALDH3A1, MAOA, IL4I1, ALDH3B1",1.68613277963085,0.643974142806877,TRUE
+"GSE12790","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.22278,-0.78,0.789,18454,1,"DGKZ, ITPR1, DGKQ, PIP5K1C, CALM1, PIP4K2C, PI4KB, PLCD4, PLCG1, IPPK, INPPL1, PIK3C2B, PIP4K2A, CDIPT, CALML6, PI4KA, PLCB1, PIK3R1, INPP5J, PLCB4, PIK3R3",0.10292299679058,0,FALSE
+"GSE12790","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.42209,-1.46,0.0798,18593,0.927,"EARS2, MMAB, HMOX1, UGT2B17, FECH, HCCS, BLVRA, UGT2B4, ALAD, UGT2B28, BLVRB",1.09799710864927,0.0329202658555029,FALSE
+"GSE12790","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.48362,1.4,0.0873,4022,0.283,"PLTP, PPARG, OLR1, FABP5, ACSL5, LPL, ACSL4, SLC27A6, EHHADH, FABP6, MMP1, CYP27A1, CYP7A1, PPARD, SLC27A2, ME1, PPARA, GK2, SCD5, ACADL, ADIPOQ, SLC27A5, CYP4A11",1.05898575629443,0.54821356447571,FALSE
+"GSE12790","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.48687,1.41,0.083,2816,0.283,"CYP7B1, AKR1C4, CH25H, CYP39A1, CYP27A1, CYP7A1, AMACR",1.08092190762393,0.54821356447571,FALSE
+"GSE12790","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.52578,1.52,0.049,3092,0.244,"LCK, IL7R, ADA, IGLL1, TAP2, CD3E, TAP1, CD40, IL2RG, AIRE",1.30980391997149,0.612610173661271,TRUE
+"GSE12790","Log2FC","KEGG_PRION_DISEASES",0.53937,1.56,0.0449,3872,0.231,"IL6, IL1A, CCL5, IL1B, PRNP, FYN, C1QA, LAMC1, EGR1, C9, PRKACG, C6",1.34775365899668,0.636388020107856,TRUE
+"GSE12790","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.22079,-0.782,0.815,20763,1,"ANAPC13, AKT1, MAPK9, ANAPC2, ADCY9, MAPK3, ADCY6, PIK3R1, PIK3R3, PGR",0.0888423912600234,0,FALSE
+"GSE12790","Log2FC","KEGG_PROPANOATE_METABOLISM",0.34971,1.01,0.427,2895,0.622,"LDHB, EHHADH, LDHAL6B, ALDH2",0.369572124974976,0.206209615309181,FALSE
+"GSE12790","Log2FC","KEGG_PROSTATE_CANCER",0.27828,0.816,0.746,4028,0.834,"GSTP1, TGFA, EGFR, PIK3CD, FOXO1, TCF7L1, TCF7, AKT3, PIK3CG, KLK3, KRAS, EGF, SRD5A2, HSP90B1, NRAS, PDGFRB, NKX3-1, PDGFC",0.127261172527331,0.0788339493622613,FALSE
+"GSE12790","Log2FC","KEGG_PROTEASOME",0.46925,1.37,0.0921,1070,0.297,"PSMB8, PSMB9, PSMA8",1.03574036980315,0.527243550682788,FALSE
+"GSE12790","Log2FC","KEGG_PROTEIN_EXPORT",-0.39994,-1.38,0.0879,14755,0.986,"SEC61A1, SEC62, SPCS2, SRP14, IMMP1L, SRP19, SRPRB, SEC11C, SPCS1, OXA1L, SRPRA, SRP54, SEC61A2",1.05601112492623,0.0061230850587888,FALSE
+"GSE12790","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.30385,0.877,0.613,5469,0.774,"CA2, SLC4A4, SLC9A3, ATP1B2, ATP1B3, GLS, ATP1B4, SLC38A3",0.212539525481585,0.111259039317107,FALSE
+"GSE12790","Log2FC","KEGG_PURINE_METABOLISM",-0.17988,-0.638,0.944,17412,1,"POLR2B, POLD2, POLR2E, RRM1, GMPR2, POLA1, ADCY4, POLR1E, NT5M, NME4, PRUNE1, PDE3B, POLR2L, POLE3, PDE7A, POLA2, FHIT, POLR2G, GUCY1A2, ATIC, ADCY2, NUDT9, PDE6D, NME1, ALLC, ADCY1, POLR2I, PDE6C, ENTPD1, POLR3B, AK1, APRT, NME7, NME3, ADCY9, POLR3K, RRM2B, ENTPD2, ADCY6, ENPP1, AMPD1",0.025028005701931,0,FALSE
+"GSE12790","Log2FC","KEGG_PYRIMIDINE_METABOLISM",0.2765,0.798,0.759,655,0.851,"CDA, NT5E, UPP1, CMPK2",0.11975822410452,0.0700704399154121,FALSE
+"GSE12790","Log2FC","KEGG_PYRUVATE_METABOLISM",0.3826,1.12,0.295,2895,0.511,"LDHB, AKR1B1, ME3, ME1, LDHAL6B, ALDH2",0.530177984021837,0.291579099865287,FALSE
+"GSE12790","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.34649,0.994,0.452,4422,0.637,"RAC2, ITGA4, ITGB4, ITGA6, MSN, ITGA2, EGFR, ITGB8, RRAS2, ITGA3, PIK3CD, MYL9, ITGB2, ITGA5, PAK3, MYH14, PAK6, FN1, FGF11, MYL2, EZR, PFN2, MYH10, PXN, ARHGEF4, ACTN4, CHRM5, CHRM4, ITGA1, GNG12, MYLPF, FGF21, PIK3CG, ITGB1, ARPC1B, RRAS, CHRM3, ITGAM, FGF2, ACTN1, RDX, CD14, PFN4, BAIAP2, KRAS, EGF, TIAM2, VAV1, DIAPH3, NRAS, DOCK1, PDGFRB, ARHGEF7, PDGFC, CFL2, MYL12A, FGF20, WASF2, CYFIP1, FGF3",0.344861565188618,0.19586056766465,FALSE
+"GSE12790","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",0.22814,0.658,0.927,1810,0.935,"GABARAPL1, IFNA4, PRKAA1",0.0329202658555029,0.0291883891274822,FALSE
+"GSE12790","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.38014,1.1,0.312,2664,0.526,"ETS1, MET, TGFA, VEGFC, PIK3CD, PAK3, PAK6, TGFB2, AKT3, EPAS1, PIK3CG, TGFB1",0.505845405981557,0.279014255846261,FALSE
+"GSE12790","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.59035,1.75,0.0131,4325,0.269,"ENPEP, ANPEP, REN, ACE, ACE2, MME, MAS1",1.88272870434424,0.570247719997592,FALSE
+"GSE12790","Log2FC","KEGG_RETINOL_METABOLISM",0.41972,1.24,0.17,5142,0.37,"DHRS3, LRAT, ALDH1A1, DHRS9, CYP26A1, UGT1A6, ALDH1A2, ADH1C, ADH1B, BCO1, ADH7, CYP4A11, DGAT1, CYP3A4, CYP2A7, ADH4, RDH10, CYP3A5, CYP2B6, CYP2C8",0.769551078621726,0.431798275933005,FALSE
+"GSE12790","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",-0.28833,-0.995,0.409,18713,0.897,"FLAD1, ACP2, RFK, PHPT1, ENPP1",0.388276691992658,0.0472075569559079,FALSE
+"GSE12790","Log2FC","KEGG_RIBOSOME",-0.13074,-0.462,1,2892,1,"RPL22L1, RPS8, RPLP2, RPS12, RPL3L, RPL14, RPS4Y1, RPL35A, RPL37, RPL38, RPS27, RPL27A, RPS27A, RPS28, RPS6, RPS7, RPS24, RPS16, RPL10L, RPL31, RPS10, RPL11, RPL8, RPS11, RPS15, RPL22, RPL3, RPL36, RPL10A, RPL12, RPL39, RPS5, RPS25, RPS3, RPS4X, RPL27, RPL7, UBA52, RPS17, RPL41, RPLP0, RPS18, RPL32, RPL6, RPL35, RPL9, RPL24, RPL18, RPL34, FAU, RPL30, RPL23A, RPS15A, RPL19, RPS9, RPL29, RPS21, MRPL13, RPLP1, RPS29, RPL37A, RPS19, RPL15, RPL26L1, RSL24D1, RPL36AL, RPS23, RPL36A, RPS27L",0,0,FALSE
+"GSE12790","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37469,1.1,0.299,3397,0.526,"CXCL8, ISG15, TNF, MAPK13, IFNA4, CXCL10, DHX58, IFNK, DDX58, IFIH1, IL12A, IFNE, IFNA7, CASP10",0.52432881167557,0.279014255846261,FALSE
+"GSE12790","Log2FC","KEGG_RNA_DEGRADATION",-0.31115,-1.13,0.28,16761,0.799,"LSM4, PAPOLA, LSM7, DCP2, EXOSC1, CNOT8, HSPA9, EDC3, EXOSC5, EXOSC2, CNOT3, PARN, DCP1A, LSM5, WDR61, EDC4, MPHOSPH6, CNOT6, EXOSC6, LSM3, LSM1, DCP1B",0.552841968657781,0.0974532206860086,FALSE
+"GSE12790","Log2FC","KEGG_RNA_POLYMERASE",-0.46291,-1.54,0.0833,15533,0.916,"POLR2K, POLR3GL, POLR3C, POLR2D, POLR3F, POLR2B, POLR2E, POLR1E, POLR2L, POLR2G, POLR2I, POLR3B, POLR3K",1.07935499859321,0.0381045263321496,FALSE
+"GSE12790","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",0.22904,0.664,0.923,2923,0.943,"CTH, CBS, PAPSS2, TRMT11",0.0347982989740879,0.0254883072626717,FALSE
+"GSE12790","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.5458,1.58,0.0226,1654,0.238,"PTGS2, LAMC2, LAMB3, COL4A1, ITGA6, ITGA2, BIRC3, COL4A2, CDK6, LAMA4, COL4A6, LAMB1, ITGA3, PIK3CD, LAMA3, FN1, CDKN2B, AKT3",1.6458915608526,0.623423042943488,TRUE
+"GSE12790","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.26151,-0.902,0.523,15847,0.939,"STX4, VAMP1, STX3, SNAP47, BNIP1, STX5, STX6, STX12, STX17, VTI1B, VAMP7, STX16, SNAP29, STX18, BET1L, VAMP8, SEC22B",0.281498311132726,0.0273344077338891,FALSE
+"GSE12790","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",-0.33412,-1.17,0.222,17742,0.798,"SPTLC1, SPTLC2, DEGS1, GLA, ACER1, ENPP7, ACER3, ARSA, PLPP3, NEU4, SPHK2, SMPD3, DEGS2",0.653647025549361,0.0979971086492706,FALSE
+"GSE12790","Log2FC","KEGG_SPLICEOSOME",-0.27459,-0.94,0.481,15286,0.864,"SF3B4, SF3B1, SNRPB, RBM22, HNRNPU, SNRPF, DDX5, SLU7, SART1, CTNNBL1, ACIN1, DDX46, SNRNP27, LSM4, PRPF38B, SNRPD3, PQBP1, SNRPD2, LSM7, EFTUD2, PRPF38A, SNW1, ZMAT2, PLRG1, SRSF1, SRSF5, SNRPE, EIF4A3, PPIH, PRPF31, THOC2, TXNL4A, LSM5, PRPF19, RBM8A, PRPF3, HNRNPA1, BCAS2, PRPF6, USP39, SF3B3, CRNKL1, ALYREF, SRSF6, HSPA6, LSM3, DDX23",0.317854923626168,0.0634862575211067,FALSE
+"GSE12790","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.38068,1.11,0.277,1596,0.517,"SI, PYGL, GYS2, MGAM, PGM1, UGT1A6",0.557520230935551,0.286509456906058,FALSE
+"GSE12790","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.33548,0.974,0.5,2666,0.665,"SOAT1, LIPA, CEL",0.301029995663981,0.177178354696895,FALSE
+"GSE12790","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.4259,1.24,0.181,5872,0.37,"AKR1C3, HSD17B2, CYP7B1, CYP11A1, AKR1C4, UGT1A6, CYP7A1, AKR1C1, CYP1B1, HSD17B8, SRD5A2, SRD5A1, CYP3A4, HSD3B2, CYP3A5, CYP11B1, CYP19A1, HSD17B12, UGT2A3",0.742321425130815,0.431798275933005,FALSE
+"GSE12790","Log2FC","KEGG_SULFUR_METABOLISM",0.43183,1.26,0.155,2686,0.356,"CHST11, PAPSS2",0.809668301829709,0.448550002027125,FALSE
+"GSE12790","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.49335,1.44,0.0671,3872,0.272,"C3, C1S, TNF, C1QA, C1R, CD40, ACTN4, HLA-DOB, HLA-DPA1, C9, CD86, ACTN1, HLA-DPB1, FCGR1A, HLA-DMA, CD28, C6",1.17327747983101,0.565431095965801,FALSE
+"GSE12790","Log2FC","KEGG_TASTE_TRANSDUCTION",0.28366,0.828,0.733,6715,0.819,"TAS2R38, TAS1R1, GNAT3, TAS2R19, SCNN1A, SCNN1G, PRKACG, TAS2R45, ADCY8, ITPR3, TAS2R5, TAS2R50, TAS2R9, TAS2R13, PRKACA, TAS2R4, TAS2R40, GNB3, TAS2R16, CACNA1B",0.134896025358872,0.0867160982395816,FALSE
+"GSE12790","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.62839,-2.12,0.0182,18955,0.263,"ADO, GGT6, BAAT, GGT5, CSAD, GAD1",1.73992861201493,0.580044251510242,FALSE
+"GSE12790","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.34607,-1.18,0.24,17198,0.835,"MVK, FDPS, HMGCR, GGPS1, PMVK",0.619788758288394,0.0783135245163979,FALSE
+"GSE12790","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.44802,1.32,0.13,5056,0.344,"INHBA, BMP2, TGFBR2, FST, TNF, ACVR1C, PITX2, INHBE, ID4, TGFB2, THBS1, ID1, CDKN2B, SMAD3, NOG, ID3, COMP, THBS2, TGFB1, SMURF2, TFDP1, BMP8B, TGFBR1, SMAD9, NODAL, THBS4, SMURF1, MYC, PPP2R1B",0.886056647693163,0.46344155742847,FALSE
+"GSE12790","Log2FC","KEGG_THYROID_CANCER",0.38104,1.11,0.299,6276,0.517,"PPARG, TCF7L1, TCF7, KRAS, NRAS, MYC, CDH1, CTNNB1, TFG, TPR, TPM3, TCF7L2, NTRK1",0.52432881167557,0.286509456906058,FALSE
+"GSE12790","Log2FC","KEGG_TIGHT_JUNCTION",0.38116,1.12,0.289,4243,0.511,"CLDN1, MYH4, GNAI1, RAB3B, CLDN11, AMOTL1, HCLS1, RRAS2, CLDN7, MYL9, MYH14, CLDN10, YBX3, CTNNA2, MYL2, CLDN6, AKT3, MYH10, PRKCA, ACTN4, MYLPF, LLGL1, RRAS, MYH15, CRB3, ACTN1, KRAS, PRKCI, NRAS, PATJ, VAPA, MYH7, MYL12A, YES1",0.539102157243452,0.291579099865287,FALSE
+"GSE12790","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45446,1.3,0.136,3291,0.361,"CXCL8, CXCL11, IL6, TLR1, CCL5, IL1B, TLR6, TLR2, TLR3, PIK3CD, TNF, MAPK13, IFNA4, AKT3, CXCL10, CD40, PIK3CG, TLR8, LY96, CD86, IL12A, IFNA7, MYD88, CD14",0.866461091629782,0.442492798094342,FALSE
+"GSE12790","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.307,0.896,0.59,6835,0.742,"MAOA, IL4I1, EHHADH, HAAO, ACMSD, CAT, ALDH2, CYP1B1, KYNU, AFMID, ACAT2, ALDH3A2, TPH1, GCDH, ACAT1, OGDH, ALDH1B1",0.229147988357856,0.129596094720973,FALSE
+"GSE12790","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",-0.29303,-1.02,0.395,20159,0.91,"GCK, IKBKB, MAPK9, MAPK3, PIK3R1, CACNA1D, KCNJ11, PIK3R3",0.40340290437354,0.0409586076789064,FALSE
+"GSE12790","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.55418,1.62,0.0205,3798,0.258,"IL1A, IL1B, HLA-G, HLA-A, HLA-B, FAS, TNF, HLA-F, HLA-C, HLA-E, HLA-DOB, HLA-DPA1, CD86, HLA-DPB1, IL12A, HLA-DMA, CD28",1.68824613894425,0.58838029403677,FALSE
+"GSE12790","Log2FC","KEGG_TYROSINE_METABOLISM",0.312,0.913,0.579,3048,0.721,"ALDH1A3, ALDH3A1, MAOA, IL4I1, ALDH3B1, ADH1C, TRMT11, ADH1B",0.237321436272564,0.142064735280571,FALSE
+"GSE12790","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29638,0.867,0.658,4534,0.78,"LCK, CARD11, CSF2, PIK3CD, PAK3, TNF, PAK6, MAPK13, IL5, CBLC, FYN, AKT3, CD3E, MAP3K14, PIK3CG, KRAS, VAV1, CBLB, NRAS, CD4, CD28, NFAT5, MAP3K8, DLG1, MAP2K7, LCP2, SOS1",0.181774106386044,0.10790539730952,FALSE
+"GSE12790","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.16853,-0.569,0.982,18236,1,"UBA1, SKP1, UBE2F, UBE2Q1, CUL3, CDC23, TRIM32, UBR5, UBE2R2, STUB1, PRPF19, ERCC8, DDB1, ANAPC11, PIAS3, HERC1, TRIM37, PIAS2, FBXW7, PPIL2, PIAS4, NEDD4, CUL1, RCHY1, MGRN1, ANAPC13, WWP1, ANAPC2, MAP3K1, UBE2QL1",0.00788851221305034,0,FALSE
+"GSE12790","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.66954,1.93,0.00248,41,0.14,"BCAT1",2.60554831917378,0.853871964321762,TRUE
+"GSE12790","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.26469,0.765,0.786,2019,0.875,"BCAT1, IL4I1, EHHADH, OXCT1",0.104577453960592,0.0579919469776868,FALSE
+"GSE12790","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.34404,1.01,0.428,4522,0.622,"CALML5, PLA2G4A, PPP1R14A, ADRA1B, CALD1, ADORA2B, ADCY7, MYL9, PLA2G1B, NPR2, PLA2G2F, PRKCA, AVPR1A, KCNMB3, KCNMB4, CACNA1S, ACTG2, ADCY3, PRKACG, CYP4A11, ADCY8, ADRA1D, ITPR3",0.368556230986828,0.206209615309181,FALSE
+"GSE12790","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.19223,-0.669,0.923,19165,1,"DCTN4, DCTN5, RAB5B, RAB11A, ADCY9, ADCY6, CREB3L4",0.0347982989740879,0,FALSE
+"GSE12790","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.4128,1.19,0.213,2099,0.436,"PTGS2, PLA2G4A, RAC2, KDR, PIK3CD, PLA2G1B, SH2D2A, MAPK13, AKT3, PLA2G2F, PXN, PRKCA",0.671620396561262,0.360513510731414,FALSE
+"GSE12790","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.2223,-0.77,0.783,17432,1,"ATP6V1C2, ATP6V1B2, ATP6V0C, ATP6V1G1, GNAS, ATP6V0A1, ATP6V1A, ATP6V0B, PLCG1, ARF1, SEC61A2, ATP6V1H, ATP6V0D1, ADCY9, ATP6V0E2, ATP6AP1",0.106238237942057,0,FALSE
+"GSE12790","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.57858,1.69,0.0155,3798,0.219,"CAV1, RAC2, MYH4, ICAM1, HLA-G, DMD, HLA-A, HLA-B, ITGB2, MYH14, CXADR, HLA-F, FYN, HLA-C, MYH10, CD40, HLA-E, HLA-DOB, HLA-DPA1, MYH15, CD86, HLA-DPB1, SGCB, HLA-DMA, CD28",1.80966830182971,0.659555885159882,TRUE
+"GSE12790","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.35484,1.06,0.37,2099,0.577,"RAC2, FOSL1, WNT10A, VANGL2, SFRP1, DKK1, WNT16, WNT11, WNT7A, FZD10, MMP7, TCF7L1, TCF7, FZD6, WNT5B, SMAD3, FZD2, PPARD, WNT9A, PRKCA",0.431798275933005,0.238824186844269,FALSE
+"GSE31625","Log2FC","KEGG_ABC_TRANSPORTERS",-0.50212,-1.56,0.0536,11075,0.38,"ABCC8, ABCC1, ABCB7, ABCG1, ABCC3, ABCA5, ABCB1, ABCA8, ABCG2, ABCA3, ABCB6, ABCC4, ABCC2",1.27083521030723,0.42021640338319,FALSE
+"GSE31625","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.35103,1.06,0.332,1915,0.617,"PIK3R3, PIK3CA, TCF7L1, PPARD, KIT, LEF1, PML, MAPK3, RARA, CCNA1, PIM1, MAPK1, SOS1, SPI1",0.478861916295964,0.209714835966758,FALSE
+"GSE31625","Log2FC","KEGG_ADHERENS_JUNCTION",0.41726,1.26,0.171,2002,0.655,"CDH1, RAC2, EGFR, FYN, AFDN, TCF7L1, WASF3, TGFBR2, PTPRF, LEF1, MAPK3, BAIAP2, YES1, ERBB2, WASL, MAPK1, CSNK2B, WASF2",0.767003889607846,0.183758700008217,FALSE
+"GSE31625","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.34739,-1.04,0.348,10834,0.643,"IRS1, CPT1A, LEP, NFKBIB, TRAF2, PRKAA2, TNFRSF1A, CHUK, PRKCQ, ACSL4, AGRP, IKBKB, PCK1, PCK2, NPY, IRS2, PPARGC1A, ACACB",0.458420756053419,0.191789027075778,FALSE
+"GSE31625","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.36242,1.11,0.272,630,0.648,"GAD1, GLUL, ABAT, GLS2",0.565431095965801,0.188424994129407,FALSE
+"GSE31625","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.41733,1.25,0.175,1179,0.628,"PIK3R3, SCNN1A, ATP1A1, PIK3CA, NEDD4L, SLC9A3R2, SFN, NR3C2, HSD11B2, MAPK3",0.756961951313706,0.202040356262804,FALSE
+"GSE31625","Log2FC","KEGG_ALLOGRAFT_REJECTION",0.55754,1.65,0.0491,1875,0.457,"HLA-DOB, HLA-C, HLA-B, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, TNF, HLA-G, HLA-DPA1, HLA-DRA, IL12A, HLA-F",1.30891850787703,0.34008379993015,FALSE
+"GSE31625","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.56233,-1.71,0.0304,12571,0.321,"FADS2, PLA2G4A",1.51712641639125,0.493494967595128,FALSE
+"GSE31625","Log2FC","KEGG_ALZHEIMERS_DISEASE",-0.25432,-0.771,0.752,10101,0.922,"LPL, NDUFA1, UQCRFS1, NDUFS1, GRIN2B, PPP3R1, CASP8, CALML5, ITPR1, NDUFA2, NDUFA4L2, APOE, CACNA1F, NDUFS2, COX7B, NDUFB1, PPP3CB, NDUFA7, CASP7, CASP9, APAF1, PSEN2, TNFRSF1A, GRIN2A, COX5A, ATP2A2, HSD17B10, CDK5R1, PPP3CC, MAPT, SNCA, APBB1, IDE, PLCB1, PLCB4",0.123782159408358,0.0352690789463706,FALSE
+"GSE31625","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.56893,-1.73,0.0243,8704,0.33,"CARS2, FARS2, IARS2, HARS2, NARS2, SARS2, DARS2",1.61439372640169,0.481486060122112,FALSE
+"GSE31625","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.35849,1.08,0.307,2325,0.627,"HK2, UAP1, HK1, NPL, PGM1, CYB5R3, NAGK, CHIA, CYB5R1, CMAS",0.512861624522813,0.202732459169284,FALSE
+"GSE31625","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.29063,-0.901,0.56,11347,0.829,"BAX, CASP9, APAF1, PRPH2, BCL2, TNFRSF1A, GRIN2A, PPP3CC, PRPH, MAP2K6, NEFM, TP53, NEFL",0.2518119729938,0.0814454694497265,FALSE
+"GSE31625","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.37187,1.13,0.251,2236,0.689,"HLA-DOB, CD74, HLA-C, HLA-B, TAPBP, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, RFXANK, CALR, HSPA1L, TAP2, KLRC3, HLA-G, HLA-DPA1, HLA-DRA, HLA-F, B2M, HSPA2",0.600326278518962,0.161780778092374,FALSE
+"GSE31625","Log2FC","KEGG_APOPTOSIS",-0.24812,-0.766,0.784,10454,0.909,"PPP3R1, CASP8, PRKAR1A, PRKAR2B, IL3RA, EXOG, PPP3CB, CASP7, TRAF2, BAX, CASP9, APAF1, BCL2, TNFRSF1A, AIFM1, CHUK, TNFRSF10D, PIK3CG, IRAK4, IKBKB, PPP3CC, IRAK3, TNFRSF10B, PRKX, TP53",0.105683937315562,0.0414361167780325,FALSE
+"GSE31625","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.49544,-1.51,0.071,11739,0.355,"ALOX12, PTGDS, CBR1, ALOX12B, CYP4F3, HPGDS, EPHX2, PTGS2, GPX2, AKR1C3, PLA2G4A",1.14874165128092,0.449771646944906,FALSE
+"GSE31625","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.37696,-1.17,0.229,10881,0.527,"PYCR1, MAOA, GLUD1, ODC1, ALDH18A1, PRODH2, ALDH4A1, AGMAT, GOT1, ALDH3A2, GLUD2, ALDH1B1, NOS3, ALDH2, CPS1",0.640164517660112,0.278189384787453,FALSE
+"GSE31625","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.27497,-0.827,0.667,12329,0.9,"CACNA2D2, DSG2, SGCB, CACNA2D3, CACNA2D1, SGCD, CDH2, GJA1",0.175874166083451,0.0457574905606751,FALSE
+"GSE31625","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.58841,-1.79,0.0162,11899,0.343,"ALDH3A2, ALDH1B1, UGT2B28, ALDH2, UGDH",1.79048498545737,0.464705879957229,FALSE
+"GSE31625","Log2FC","KEGG_ASTHMA",0.41641,1.26,0.175,1744,0.655,"HLA-DOB, HLA-DQB1, HLA-DRB1, TNF, HLA-DPA1, FCER1A, HLA-DRA",0.756961951313706,0.183758700008217,FALSE
+"GSE31625","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.3665,1.1,0.293,1875,0.64,"HLA-DOB, HLA-C, HLA-B, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, HLA-G, HLA-DPA1, HLA-DRA, HLA-F",0.533132379645891,0.193820026016113,FALSE
+"GSE31625","Log2FC","KEGG_AXON_GUIDANCE",0.41715,1.25,0.159,2676,0.628,"SEMA5A, RAC2, ABLIM3, PAK6, EFNB2, RHOD, FYN, EPHA1, EPHA4, EPHB3, EPHB6, LIMK2, PLXNA3, PAK1, EPHA2, SEMA3C, PLXNA2, RASA1, MAPK3, EFNA4, GNAI2, SEMA3E, EFNA3, PLXNB3, SEMA4A, PLXNA1, UNC5C, SEMA3D, EPHB2, MAPK1, PLXNB2, GNAI3, NFAT5, PPP3CA, SEMA4C, EPHB4, RAC1, NRP1, NFATC4, SEMA3F, PTK2, PAK2",0.798602875679548,0.202040356262804,FALSE
+"GSE31625","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.34055,1.04,0.368,1669,0.61,"WNT4, BMP2, TCF7L1, WNT5A, WNT7B, WNT7A, LEF1, WNT5B, DVL3, WNT2, FZD1, FZD6",0.434152181326482,0.214670164989233,FALSE
+"GSE31625","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.25522,-0.777,0.75,8728,0.934,"TBPL1, GTF2E1, TAF6, TAF6L, TAF5, GTF2H1, GTF2F1, TAF9B, GTF2A2, GTF2A1, TAF10, STON1, GTF2E2",0.1249387366083,0.0296531237699066,FALSE
+"GSE31625","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.35632,-1.07,0.333,9962,0.606,"MPG, POLE3, POLL, OGG1, PARP2, PCNA, NTHL1, LIG3, NEIL3, APEX1",0.47755576649368,0.217527375833714,FALSE
+"GSE31625","Log2FC","KEGG_BETA_ALANINE_METABOLISM",0.35546,1.07,0.314,717,0.635,"GAD1, ABAT, DPYD",0.503070351926785,0.197226274708024,FALSE
+"GSE31625","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.65528,-2.02,0.00401,12516,0.217,"PECR, FADS2, SCD, ELOVL2, BAAT",2.39685562737982,0.66354026615147,TRUE
+"GSE31625","Log2FC","KEGG_BLADDER_CANCER",0.46817,1.43,0.0931,1813,0.611,"CDH1, EGFR, THBS1, VEGFA, MMP1, CDKN2A, E2F1, MAPK3, ERBB2, VEGFB, MMP9, MMP2, MAPK1",1.03105031901866,0.213958789757446,FALSE
+"GSE31625","Log2FC","KEGG_BUTANOATE_METABOLISM",-0.38026,-1.14,0.275,11801,0.532,"GAD2, ALDH3A2, ACADS, PDHA1, ALDH1B1, ACAT1, ALDH2, ACSM3, AKR1B10",0.560667306169737,0.274088367704952,FALSE
+"GSE31625","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.43838,1.33,0.139,2982,0.679,"RAC2, CR2, PIK3R3, SYK, IFITM1, PIK3CA, JUN, BLNK, DAPP1, BCL10, MAPK3, VAV2, CD22, NFKBIA, MAPK1, SOS1, PTPN6, NFAT5, PPP3CA, VAV1, LYN, RAC1, NFATC4, FOS, MALT1, RELA, RAC3, NRAS",0.856985199745905,0.168130225719498,FALSE
+"GSE31625","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.25497,-0.767,0.789,10230,0.919,"SLC25A4, TBXA2R, PDGFRA, VDAC1, SLC25A5, PHKA2, P2RX6, PPP3R1, CALML5, ITPR1, CACNA1F, P2RX5, PTGFR, RYR2, PPP3CB, P2RX1, CHRM5, DRD1, VDAC2, CACNA1H, ATP2B1, GRIN2A, F2R, ATP2A2, PHKA1, VDAC3, PRKCB, TRPC1, MYLK3, PPP3CC, CACNA1G, BDKRB1, ADRA1D, MYLK, AGTR1, CD38, NOS3, PDE1C, PLCB1, SLC25A6, PRKX, HTR2B, GNAL, BDKRB2, PLCB4, PDE1A, BST1",0.10292299679058,0.0366844886138887,FALSE
+"GSE31625","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.27341,-0.843,0.67,9495,0.904,"COX7A2L, UQCRB, ATP1B3, COX5B, MYH7, MYL3, UQCRFS1, ACTC1, CACNA1F, COX7B, RYR2, CACNG2, TNNT2, CACNB2, COX5A, ATP2A2, CACNA2D2, CACNA2D3, TPM2, CACNA2D1, FXYD2",0.173925197299174,0.0438315695246367,FALSE
+"GSE31625","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.48023,1.43,0.0949,1583,0.611,"CDH3, CLDN4, CLDN7, CDH1, CDH5, SDC4, SDC2, ICAM1, F11R, PECAM1, HLA-DOB, ITGA6, ITGB2, ICAM2, HLA-C, OCLN, HLA-B, ITGA4, HLA-DQB1, CD58, SDC3, GLG1, ICAM3, HLA-A, PTPRF, SELE, HLA-DRB1, HLA-E, ITGB8, CLDN9, CLDN3, CLDN8, CD22, HLA-G, HLA-DPA1, SDC1",1.02273378757271,0.213958789757446,FALSE
+"GSE31625","Log2FC","KEGG_CELL_CYCLE",0.17128,0.529,0.994,2991,1,"CCNE2, CDKN2A, SFN, CDC20, MAD1L1, E2F1, HDAC1, RBX1, SKP2, CCNA1, CCNE1, CDC25A, CCNA2, RAD21, CDKN2B, CDK6, MCM2, MCM5, CCND1, BUB1B, CDKN1B, TTK, GADD45A, CDC45, YWHAB, YWHAH, YWHAZ, RBL2",0.00261361560268669,0,FALSE
+"GSE31625","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.30287,-0.936,0.518,12566,0.798,"CCL7, GNB5, CXCL8, CCR7, CCL20, PLCB1, PF4, PRKX, CCL2, PLCB4, CXCL2, ARRB2, CXCL1, CXCL3, ELMO1, GNG11, CXCL5",0.285670240254767,0.0979971086492706,FALSE
+"GSE31625","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.3077,0.942,0.517,2416,0.672,"CBLC, PIK3R3, PIK3CA, CDKN2A, TGFBR2, BCR, E2F1, HDAC1, MAPK3, MECOM, NFKBIA, MAPK1, SOS1, CDK6, CBLB, CTBP1, CCND1, CDKN1B",0.286509456906058,0.172630726946175,FALSE
+"GSE31625","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.53958,1.57,0.0664,953,0.457,"BHLHE41, CSNK1E, PER3, CRY2",1.17783192063198,0.34008379993015,FALSE
+"GSE31625","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.39839,-1.22,0.186,11383,0.491,"SUCLG2, OGDHL, FH, IDH3A, PDHA1, ACLY, PCK1, PCK2, IDH1",0.730487055782084,0.308918507877032,FALSE
+"GSE31625","Log2FC","KEGG_COLORECTAL_CANCER",0.32142,0.968,0.458,1216,0.681,"RAC2, PIK3R3, PIK3CA, JUN, TCF7L1, TGFBR2, LEF1, MAPK3, RALGDS",0.339134521996131,0.166852888087215,FALSE
+"GSE31625","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.53371,-1.63,0.0436,12676,0.331,"THBD, F2, C4BPA, CFD, TFPI, CPB2, C1R, C5AR1, BDKRB2, PROS1, C5, CFH, FGA, SERPINE1, C1S, FGB, FGG",1.36051351073141,0.480172006224281,FALSE
+"GSE31625","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.37872,-1.15,0.252,9600,0.539,"LDHC, TRDMT1, BHMT, AHCY, SRM, DNMT3L, AMD1, MAT1A, APIP, LDHB, GOT1, CTH, LDHAL6B, MAT2A",0.598599459218456,0.268411234813261,FALSE
+"GSE31625","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.2648,-0.802,0.717,11488,0.919,"IL17RB, PPBP, IFNA4, TNFRSF1A, CCL11, TNFRSF8, IL11RA, IFNB1, IFNA17, IFNA2, VEGFC, IL11, ACVR1, TNFRSF10D, TNFSF18, IL18R1, INHBE, CCR10, TGFBR1, EDA2R, IL18RAP, CCL7, TNFRSF11B, CSF2RA, CXCL8, CCR7, CCL20, FLT4, TNFRSF10B, PF4, IL18, LIF, BMPR1B, TNFSF9, CCL2, CXCL2, CXCL1, IL15, CD70, CXCL3, CXCL5",0.1444808443322,0.0366844886138887,FALSE
+"GSE31625","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.27351,0.849,0.644,698,0.755,"DDX58, CCL5, CASP1, IL6, AIM2",0.191114132640188,0.122053048370812,FALSE
+"GSE31625","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.2737,0.824,0.66,1624,0.784,"TNNC1, ITGA6, ITGA3, ITGA2, ITGA4, ITGB4, DMD, ITGB8, TNF, PRKACA, DAG1, ITGA1, ADCY8",0.180456064458131,0.105683937315562,FALSE
+"GSE31625","Log2FC","KEGG_DNA_REPLICATION",-0.15507,-0.468,0.998,2057,0.999,"MCM2, MCM5, SSBP1, RFC1, RNASEH2A, LIG1, POLD3, POLA2, RPA3, POLD2, RFC4, RFC2, MCM3, PRIM2, FEN1, POLD1, POLE, RPA1, MCM4, DNA2, RFC5, MCM6, POLE2, RNASEH2B, RPA2, POLD4, RFC3, POLE3, MCM7, RNASEH1, RPA4, PRIM1, PCNA, POLA1",0.000869458712628891,0.000434511774017692,FALSE
+"GSE31625","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.38923,1.18,0.194,2045,0.674,"EGFR, MAPK3, NOTCH2, ETV6, MAPK1, SOS1, ETV7",0.712198270069774,0.17134010346468,FALSE
+"GSE31625","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.40502,-1.23,0.211,11906,0.488,"CYP3A43, GSTM4, FMO1, GSTO1, ADH6, GSTM2, GSTM1, UGT2B28, CYP3A5, ALDH3B1, GSTA4, GSTP1, ALDH3A1",0.675717544702307,0.311580177997289,FALSE
+"GSE31625","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.33914,1.01,0.4,1936,0.638,"CDA, UPP1, UGT2B17, DPYD, UGT2B4, UCKL1, XDH",0.397940008672038,0.195179321278838,FALSE
+"GSE31625","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.41761,1.26,0.172,910,0.655,"TNC, LAMB3, SDC4, LAMC2, LAMA3, THBS1, SDC2, HSPG2, ITGA6, ITGA3, ITGA2, ITGA4, ITGB4, CD36, CD47, CD44, LAMA4, SDC3, COL6A2",0.764471553092451,0.183758700008217,FALSE
+"GSE31625","Log2FC","KEGG_ENDOCYTOSIS",0.45552,1.37,0.109,1493,0.622,"EPN3, CBLC, EGFR, SH3GL2, ARAP2, ADRB2, SMURF2, VPS37B, EHD1, RAB11FIP1, HLA-C, CSF1R, PRKCZ, HLA-B, PSD4, NEDD4L, PARD6B, ITCH, RAB31, LDLRAP1, PRKCI, ARRB1, EHD2, DNM3, SH3GLB2, CLTB, HLA-A, ASAP2, KIT, ARFGAP3, ERBB3, EHD4, AGAP1, HLA-E, GRK4, EPN1, ARFGAP2, RAB22A, HSPA1L, HLA-G",0.962573502059376,0.206209615309181,FALSE
+"GSE31625","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.37083,1.11,0.267,1865,0.648,"CDH1, EGFR, PIK3R3, FOXO3, PIK3CA, TCF7L1, LEF1, MAPK3, ERBB2, MAPK1, SOS1",0.573488738635425,0.188424994129407,FALSE
+"GSE31625","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.34798,1.05,0.349,2502,0.601,"MAPK13, EGFR, CCL5, F11R, HBEGF, JUN, PAK1, MAPK11, ATP6V0A4, MAPK14, NFKBIA, MAPK12, PTPRZ1, ADAM10, LYN, RAC1, ATP6V0D1",0.45717457304082,0.22112552799726,FALSE
+"GSE31625","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.36627,1.12,0.277,1179,0.676,"CBLC, PAK6, TGFA, EGFR, PIK3R3, HBEGF, CAMK2G, PIK3CA, JUN, BTC, PAK1, ERBB3, MAPK3",0.557520230935551,0.170053304058364,FALSE
+"GSE31625","Log2FC","KEGG_ETHER_LIPID_METABOLISM",-0.41253,-1.27,0.164,12708,0.491,"CHPT1, ENPP2, PLA2G4A",0.785156151952302,0.308918507877032,FALSE
+"GSE31625","Log2FC","KEGG_FATTY_ACID_METABOLISM",-0.37325,-1.13,0.265,9169,0.539,"ADH7, ADH1C, ACSL6, ECHS1, ALDH7A1, HADHA, ACAA2, ECI1, CPT1A, EHHADH, ACADL, ECI2, ACSL4, ALDH3A2, ACADSB, ACADS, ADH6, ALDH1B1, ACAT1, ALDH2",0.576754126063192,0.268411234813261,FALSE
+"GSE31625","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.40605,1.23,0.171,1900,0.604,"MAPK13, RAC2, PIK3R3, SYK, FYN, PRKCD, PIK3CA, PLA2G12A, MAPK11, MAPK3, TNF, VAV2, FCER1A, MAPK14, MAPK1, SOS1, MAPK12",0.767003889607846,0.218963061378868,FALSE
+"GSE31625","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.38189,1.13,0.258,2650,0.689,"RAC2, PIK3R3, SYK, PRKCD, GSN, PIK3CA, LIMK2, MARCKS, PAK1, WASF3, MARCKSL1, DNM3, ASAP2, MAPK3, VAV2, PLPP3, SCIN, WASL, MAPK1, WASF2, ARPC1A, VAV1, LYN, RAC1, ARPC5L, VASP",0.58838029403677,0.161780778092374,FALSE
+"GSE31625","Log2FC","KEGG_FOCAL_ADHESION",0.30583,0.927,0.519,910,0.682,"MYL9, TNC, LAMB3, RAC2, LAMC2, PAK6, LAMA3, EGFR, PIK3R3, PDGFC, THBS1, FYN, ITGA6, ITGA3, ITGA2, ITGA4, ITGB4, PIK3CA, JUN, VEGFA, LAMA4, PDGFB, PAK1, COL6A2",0.284832642151542,0.166215625343521,FALSE
+"GSE31625","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.74246,2.21,0.00186,6,0.196,"ALPP",2.73048705578208,0.707743928643524,TRUE
+"GSE31625","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.33459,-1.01,0.39,11561,0.68,"FBP2, MTMR6, KHK, PFKM, PFKFB3, AKR1B10",0.408935392973501,0.167491087293764,FALSE
+"GSE31625","Log2FC","KEGG_GALACTOSE_METABOLISM",-0.38902,-1.17,0.237,11438,0.527,"B4GALT1, GALK2, PFKM, GAA, GLA, MGAM, GALK1",0.625251653989896,0.278189384787453,FALSE
+"GSE31625","Log2FC","KEGG_GAP_JUNCTION",-0.33968,-1.03,0.371,12755,0.651,"PLCB1, SRC, PRKX, TUBB2B, HTR2B, TUBAL3, PLCB4, TUBA1A, GJA1",0.430626090384954,0.186419011431808,FALSE
+"GSE31625","Log2FC","KEGG_GLIOMA",0.31617,0.954,0.45,1982,0.667,"TGFA, EGFR, PIK3R3, CAMK2G, PIK3CA, CDKN2A, PDGFB, E2F1, MAPK3, PDGFA, MAPK1, SOS1, CDK6",0.346787486224656,0.175874166083451,FALSE
+"GSE31625","Log2FC","KEGG_GLUTATHIONE_METABOLISM",-0.44612,-1.37,0.126,11945,0.41,"GCLC, GSTM4, GSTO1, GCLM, GSTM2, GSTM1, IDH1, GSTA4, G6PD, GSR, PGD, GSTP1, GPX2",0.899629454882437,0.387216143280265,FALSE
+"GSE31625","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",-0.35911,-1.1,0.285,11833,0.571,"GK, PNLIP, AGPAT4, ALDH3A2, PNLIPRP2, DGKI, ALDH1B1, ALDH2, GLA, DGKD, DGKG",0.54515513999149,0.243363891754152,FALSE
+"GSE31625","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.31996,-0.98,0.423,11881,0.735,"AGPAT4, PTDSS2, ADPRM, CDS2, DGKI, PEMT, GPD1L, CHPT1, LPGAT1, DGKD, DGKG, PLA2G4A",0.373659632624958,0.133712660915805,FALSE
+"GSE31625","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.38219,-1.16,0.257,10896,0.533,"MAOA, AOC2, SHMT2, CTH, AOC3, PSAT1, GLDC",0.590066876668705,0.273272790973428,FALSE
+"GSE31625","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.36829,-1.11,0.278,12303,0.564,"PDHA1, LDHAL6B, PFKM, ADH6, ALDH1B1, ENO2, PCK1, PCK2, ALDH2, ALDH3B1, ENO3, ALDH3A1",0.555955204081924,0.248720896016658,FALSE
+"GSE31625","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.38437,-1.17,0.232,11579,0.527,"B3GAT1, UST, CSGALNACT2, CHST7, CSGALNACT1",0.6345120151091,0.278189384787453,FALSE
+"GSE31625","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.23939,0.732,0.839,2945,0.905,"NDST1, HS2ST1, HS3ST1, EXT1, XYLT1, XYLT2, EXT2",0.0762380391712997,0.0433514207947967,FALSE
+"GSE31625","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.3471,1.05,0.339,2111,0.601,"ST3GAL1, B3GNT2, FUT8, CHST4",0.469800301796918,0.22112552799726,FALSE
+"GSE31625","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.38847,-1.14,0.275,11225,0.532,"HYAL3, NAGLU, HPSE2, HEXA, HYAL1, HS3ST3A1",0.560667306169737,0.274088367704952,FALSE
+"GSE31625","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.43871,1.32,0.144,733,0.667,"ST8SIA1, ST3GAL1, ST6GALNAC5",0.84163750790475,0.175874166083451,FALSE
+"GSE31625","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.64803,2.03,0.00405,586,0.309,"B3GALNT1, ST8SIA1, FUT1, ST3GAL1, FUT9",2.39254497678533,0.510041520575165,FALSE
+"GSE31625","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.63731,1.93,0.00595,1616,0.255,"ST8SIA1, B3GNT3, FUT3, FUT1, FUT6, FUT9, ST3GAL6, FUT4, ST3GAL4, B3GNT2",2.22548303427145,0.593459819566045,FALSE
+"GSE31625","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.34702,-1.05,0.353,11337,0.634,"PIGL, PIGB, PGAP1, PIGN, PIGH, PIGF",0.452225294612177,0.197910742118267,FALSE
+"GSE31625","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.41914,-1.26,0.176,7722,0.465,"ACO1, MDH1, MDH2, MTHFD2, HAO2, HAO1, MTHFD1, GRHPR, MTHFD2L",0.75448733218585,0.332547047110046,FALSE
+"GSE31625","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.30737,0.942,0.5,1990,0.672,"MAPK13, EGFR, PRKCD, HBEGF, MAP3K1, CAMK2G, JUN, PLA2G12A, MAPK11, MAPK3, PRKACA, ADCY8, MAPK14, MMP2, MAPK1, ITPR3, ADCY6, SOS1, MAPK12, MAPK7",0.301029995663981,0.172630726946175,FALSE
+"GSE31625","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.5758,1.74,0.0252,1875,0.418,"HLA-DOB, HLA-C, HLA-B, IL6, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, TNF, HLA-G, HLA-DPA1, HLA-DRA, HLA-F",1.59859945921846,0.378823718224965,FALSE
+"GSE31625","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.42573,1.28,0.168,1620,0.698,"WNT4, CSNK1E, BMP5, GAS1, BMP2, WNT5A, WNT7B, BMP7, WNT7A, WNT5B, PRKACA, WNT2, IHH",0.774690718274137,0.156144577376839,FALSE
+"GSE31625","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.46726,1.42,0.0925,1827,0.591,"MME, CD9, CR2, IL7R, ANPEP, ITGA6, IL4R, ITGA3, ITGA2, CSF1R, ITGA4, IL6, CD36, CD59, CD44, KIT, HLA-DRB1, TNF, CD22, ITGA1, HLA-DRA, GP9",1.03385826726097,0.228412519118745,FALSE
+"GSE31625","Log2FC","KEGG_HISTIDINE_METABOLISM",-0.47052,-1.42,0.119,12408,0.405,"ALDH1B1, ALDH2, ALDH3B1, DDC, ALDH3A1",0.924453038607469,0.392544976785331,FALSE
+"GSE31625","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.18071,0.55,0.992,3544,1,"RAD54L, XRCC3, SSBP1, POLD3, BRCA2, RPA3, POLD2",0.00348832784582135,0,FALSE
+"GSE31625","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.26373,-0.815,0.715,10069,0.914,"CLTA, POLR2D, NDUFA1, UQCRFS1, SLC25A4, VDAC1, UCP1, NDUFS1, SLC25A5, GRIN2B, AP2B1, CASP8, ITPR1, NDUFA2, POLR2C, NDUFA4L2, NDUFS2, COX7B, NDUFB1, NDUFA7, VDAC2, AP2A2, BAX, CASP9, APAF1, DCTN2, COX5A, CLTCL1, VDAC3, POLR2L, PLCB1, SLC25A6, BDNF, PPARGC1A, PLCB4, TP53",0.145693958198919,0.0390538042661686,FALSE
+"GSE31625","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.32397,0.982,0.434,1539,0.674,"TNNC1, ITGA6, ITGA3, ITGA2, ITGA4, IL6, ITGB4, PRKAA1, DMD, ITGB8, TNF, DAG1, ITGA1",0.362510270487489,0.17134010346468,FALSE
+"GSE31625","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.25021,-0.774,0.793,12515,0.928,"MINPP1, IMPA1, PLCB1, PTEN, PLCB4",0.100726812682396,0.0324520237811379,FALSE
+"GSE31625","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",-0.21791,-0.651,0.954,10067,0.982,"PKLR, PRKACB, PPP1CC, PYGB, ARAF, PRKAB1, CRK, PHKA2, HRAS, CALML5, PPP1CB, PRKAR1A, FLOT2, PRKAR2B, SOCS2, IRS1, SHC2, ACACA, PRKAA2, FBP2, EIF4EBP1, GYS2, PHKA1, FOXO1, PIK3CG, IKBKB, SHC1, SREBF1, PCK1, PCK2, PDE3B, PRKX, IRS2, PDE3A, PPP1R3C, RHOQ, PPARGC1A, ACACB",0.0204516252959049,0.00788851221305034,FALSE
+"GSE31625","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.37379,1.12,0.278,1744,0.676,"TNFSF13, HLA-DOB, IL15RA, ITGA4, IL6, HLA-DQB1, HLA-DRB1, HLA-DPA1, HLA-DRA",0.555955204081924,0.170053304058364,FALSE
+"GSE31625","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.23983,0.717,0.86,2362,0.919,"CBLC, PIK3R3, IL7R, IL4R, IL15RA, IL6, PIK3CA, GHR, IL20RA, SPRY1, IRF9, CTF1, SPRY2, PIM1, IL12A, SOS1, STAT2, CISH, SOCS1, PTPN6, CBLB, OSMR, MPL, CCND1",0.0655015487564323,0.0366844886138887,FALSE
+"GSE31625","Log2FC","KEGG_LEISHMANIA_INFECTION",0.50269,1.52,0.0791,1900,0.508,"MAPK13, HLA-DOB, NCF4, ITGB2, NCF2, ITGA4, TLR2, TLR4, JUN, HLA-DQB1, MARCKSL1, MAPK11, HLA-DRB1, MAPK3, TAB1, TNF, HLA-DPA1, MAPK14, HLA-DRA, IL12A, NFKBIA, MAPK1, TAB2, MAPK12",1.10182351650232,0.294136287716081,FALSE
+"GSE31625","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.5286,1.62,0.0513,1326,0.457,"CLDN4, CLDN7, MAPK13, CDH5, MYL9, RAC2, PIK3R3, ICAM1, F11R, PECAM1, NCF4, ITGB2, NCF2, OCLN, ITGA4, PIK3CA, AFDN, MAPK11, SIPA1, CLDN9, GNAI2, CLDN3, CLDN8, VAV2",1.28988263488818,0.34008379993015,FALSE
+"GSE31625","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.6727,-2.06,0,9534,0.258,"ECHS1, ALDH7A1, HADHA, EHHADH, ALDH3A2, ALDH1B1, ALDH2",Inf,0.58838029403677,FALSE
+"GSE31625","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",-0.59451,-1.79,0.0191,12816,0.343,"CYP3A5, PLA2G4A, AKR1B10",1.71896663275227,0.464705879957229,FALSE
+"GSE31625","Log2FC","KEGG_LONG_TERM_DEPRESSION",-0.27569,-0.803,0.686,12677,0.929,"IGF1R, PLCB1, PLCB4, PLA2G4A",0.163675884293248,0.0319842860063582,FALSE
+"GSE31625","Log2FC","KEGG_LONG_TERM_POTENTIATION",-0.24147,-0.737,0.835,9849,0.907,"MAP2K2, ADCY1, CAMK2B, PRKACB, PPP1CC, ARAF, GRIN2B, RPS6KA6, PPP3R1, HRAS, CALML5, ITPR1, PPP1CB, PPP3CB, RPS6KA3, GRIN2A, PRKCB, PPP3CC, PLCB1, PRKX, PLCB4",0.0783135245163979,0.0423927129399047,FALSE
+"GSE31625","Log2FC","KEGG_LYSINE_DEGRADATION",-0.24811,-0.759,0.784,11191,0.911,"SUV39H1, EHHADH, OGDHL, ALDH3A2, AASS, ALDH1B1, ACAT1, ALDH2",0.105683937315562,0.0404816230270017,FALSE
+"GSE31625","Log2FC","KEGG_LYSOSOME",0.31179,0.921,0.531,2320,0.676,"LAMP3, CTSH, CTSV, LAPTM5, FUCA1, CLTB, CTSE, AP1M2, AP1G1, ATP6V0A4, ACP5, PPT1, CTSA, AP3B2, SORT1, AP1B1, ACP2, PLA2G15, LAMP1, AP3S1, GGA1, MANBA, NAGA, NEU1, LAMP2, CTSO, CD164, AP1S1, SCARB2, GGA2",0.274905478918531,0.170053304058364,FALSE
+"GSE31625","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",-0.22142,-0.672,0.909,12209,0.982,"IKBKB, PPP3CC, MAPT, CDC25B, TGFBR1, CACNA2D2, CACNA1G, CD14, MYC, FGF13, NR4A1, MAP3K8, CACNA2D3, MAP2K6, PRKX, CACNA2D1, MAP3K12, BDNF, DUSP4, DUSP1, FGFR4, TP53, ARRB2, FGF2, PLA2G4A",0.0414361167780325,0.00788851221305034,FALSE
+"GSE31625","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.5346,-1.65,0.0418,11179,0.335,"MNX1, NKX6-1, HNF1A, NKX2-2, NR5A2, HNF1B, FOXA2, HHEX",1.37882371822496,0.474955192963155,FALSE
+"GSE31625","Log2FC","KEGG_MELANOGENESIS",0.32292,0.968,0.462,1843,0.681,"WNT4, CAMK2G, TCF7L1, WNT5A, WNT7B, KIT, WNT7A, LEF1, CREB3L1, MAPK3, ASIP, WNT5B, GNAI2, DVL3, PRKACA, WNT2, ADCY8, FZD1, FZD6, GNAO1, MAPK1, ADCY6",0.335358024443874,0.166852888087215,FALSE
+"GSE31625","Log2FC","KEGG_MELANOMA",0.34019,1.03,0.368,1179,0.609,"CDH1, EGFR, PIK3R3, PDGFC, PIK3CA, FGF12, CDKN2A, PDGFB, FGF9, E2F1, MAPK3",0.434152181326482,0.215382707367125,FALSE
+"GSE31625","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.52093,-1.56,0.0492,11906,0.38,"CYP3A43, GSTM4, GSTO1, ADH6, GSTM2, GSTM1, UGT2B28, CYP3A5, ALDH3B1, EPHX1, AKR1C4, GSTA4, GSTP1, AKR1C3, AKR1C1, ALDH3A1",1.30803489723264,0.42021640338319,FALSE
+"GSE31625","Log2FC","KEGG_MISMATCH_REPAIR",-0.21651,-0.664,0.952,8958,0.98,"MSH3, RPA2, POLD4, MLH3, RFC3, RPA4, MLH1, PCNA, EXO1",0.0213630516155257,0.00877392430750515,FALSE
+"GSE31625","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35175,1.06,0.336,1887,0.617,"PIK3R3, RPS6KA2, PIK3CA, VEGFA, PRKAA1, CAB39, MAPK3, VEGFB, MAPK1, RPS6KA1",0.473660722610156,0.209714835966758,FALSE
+"GSE31625","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.36335,1.09,0.312,2225,0.633,"RAC2, PIK3R3, SYK, FYN, TNFSF10, ICAM1, ITGB2, ICAM2, HLA-C, HLA-B, PIK3CA, PAK1, HLA-A, MAPK3, HLA-E, TNF, VAV2, KLRC3, HLA-G, ULBP2, MICB, MAPK1, SOS1, SH3BP2, PTPN6, NFAT5, PPP3CA, VAV1, BID",0.505845405981557,0.198596289982645,FALSE
+"GSE31625","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.29734,-0.908,0.52,9902,0.826,"NTSR2, OPRM1, GABRG2, GH1, S1PR4, CHRNB4, PARD3, APLNR, MC4R, GABBR1, MTNR1A, TBXA2R, LPAR4, GRIN2B, P2RX6, CHRNA9, GHRHR, DRD3, ADCYAP1R1, MC3R, NR3C1, SSTR1, P2RX5, GABRA6, SSTR2, PTGFR, MC2R, TSHR, HCRTR2, HCRTR1, PTH1R, GABRD, CHRNA3, PTGIR, LTB4R, ADRA2A, LEP, P2RX1, PTGER2, GLRA2, CHRM5, THRA, DRD1, GABRB2, GHSR, F2RL3, NPY5R, LPAR3, GNRHR, GRM8, TAAR5, GRIK4, GRIN2A, HRH3, GZMA, F2R, GRM2, P2RY1, GALR2, VIPR2, GRIA4, CHRM4, PLG, GPR50, FPR3, BDKRB1, ADRA1D, MCHR1, GABRA1, AGTR1, CALCRL, NPY1R, ADRA2C, CHRNA5, F2, F2RL2, HTR1D, LPAR6, C5AR1, HTR2B, GLP2R, BDKRB2, GABRB3, GABRA5",0.283996656365201,0.0830199526796178,FALSE
+"GSE31625","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.35462,1.06,0.314,2064,0.617,"ARHGDIB, MAPK13, PIK3R3, PRKCD, FOXO3, RPS6KA2, MAP3K1, NGF, CAMK2G, PIK3CA, MAP3K5, JUN, MAPK11, MAPK3, SORT1, MAPK14, ZNF274, NFKBIA, MAPK1, SOS1, RAPGEF1, RPS6KA1, MAPK12, MAPK7, RAP1A, MAPKAPK2",0.503070351926785,0.209714835966758,FALSE
+"GSE31625","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.51606,-1.55,0.0572,12473,0.368,"PNP, CD38, NT5C2, NAMPT, NT5M, NT5C, NADSYN1, BST1",1.24260397120698,0.434152181326482,FALSE
+"GSE31625","Log2FC","KEGG_NITROGEN_METABOLISM",-0.57405,-1.73,0.0244,12041,0.33,"CTH, GLUD2, ASNS, CA8, CPS1, CA12",1.61261017366127,0.481486060122112,FALSE
+"GSE31625","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34318,1.05,0.353,1900,0.601,"MAPK13, CCL5, NOD2, CASP1, IL6, CASP5, MAPK11, MAPK3, TAB1, TNF, MAPK14, BIRC3, NFKBIA, MAPK1, TAB2, MAPK12",0.452225294612177,0.22112552799726,FALSE
+"GSE31625","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",0.33044,0.988,0.426,448,0.673,"POLM",0.370590400897281,0.171984935776023,FALSE
+"GSE31625","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.37798,1.15,0.241,1982,0.681,"TGFA, EGFR, PIK3R3, FOXO3, PIK3CA, CDKN2A, E2F1, MAPK3, ERBB2, MAPK1, SOS1, CDK6",0.617982957425132,0.166852888087215,FALSE
+"GSE31625","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.33751,1.03,0.381,2644,0.609,"DTX4, JAG2, HDAC1, DVL3, NOTCH2, RBPJ, HES1, CTBP1, NCSTN, NOTCH3",0.419075024324381,0.215382707367125,FALSE
+"GSE31625","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.15335,0.456,0.998,3795,0.999,"ERCC2, RBX1, RAD23A, RAD23B, ERCC6, RFC1, LIG1, CETN2, POLD3, RPA3, GTF2H5, POLD2, RFC4, GTF2H4",0.000869458712628891,0.000434511774017692,FALSE
+"GSE31625","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.3702,1.11,0.299,3764,0.648,"MAN1A1, MGAT4A, ALG12, FUT8, MGAT1, RPN2, GANAB, DPM1, B4GALT3, ST6GAL1, DDOST, RPN1, MAN1B1, MGAT3, MAN2A1, B4GALT2, MOGS",0.52432881167557,0.188424994129407,FALSE
+"GSE31625","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",-0.29413,-0.891,0.567,9187,0.839,"OR2B6, GUCA1A, OR7A10, OR2B2, OR2J2, OR2F2, OR2H1, OR10C1, OR1A2, OR51E2, CAMK2B, PRKACB, OR10H2, CLCA4, CALML5, OR2S2, OR1D5, OR1E1, PRKG2, OR52A1, PDC, CLCA1, OR10H3, PDE1C, PRKX, GNAL, ARRB2",0.246416941107093,0.0762380391712997,FALSE
+"GSE31625","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.42185,-1.29,0.138,8382,0.474,"MTR, MTHFD2, ATIC, MTHFD1, AMT, SHMT2, MTHFD2L",0.860120913598763,0.324221658325915,FALSE
+"GSE31625","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.18961,-0.572,0.981,9903,1,"ADCY1, ADCY9, CDC16, CAMK2B, ANAPC13, PRKACB, PPP1CC, RPS6KA6, PPP3R1, CALML5, ITPR1, PPP1CB, ANAPC5, PGR, PPP3CB, PPP2CB, BTRC, SLK, RPS6KA3, MOS, SMC3, AR, SMC1A, PPP3CC, IGF1R, PRKX, CPEB1",0.0083309926200515,0,FALSE
+"GSE31625","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.29949,-0.924,0.519,9906,0.813,"MAN2B1, ENGASE, NEU3, AGA, MAN2C1, HEXA",0.284832642151542,0.0899094544059319,FALSE
+"GSE31625","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.25779,-0.789,0.725,8668,0.922,"ATP6V1H, COX4I1, COX7A2, COX7C, ATP6V1G2, ATP6V1B2, NDUFS7, COX7A2L, UQCRB, COX5B, NDUFB8, NDUFA1, UQCRFS1, NDUFS1, COX10, NDUFA2, NDUFA4L2, NDUFS2, COX7B, NDUFB1, ATP6V0E2, NDUFA7, ATP12A, ATP6V1B1, COX5A, ATP4B, COX15, COX11, TCIRG1",0.139661993429006,0.0352690789463706,FALSE
+"GSE31625","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.53622,1.61,0.0489,1634,0.428,"GALNT6, GALNT3, ST3GAL1, GALNT12, B4GALT5, C1GALT1, GALNT7, GALNT2",1.31069114087638,0.368556230986828,FALSE
+"GSE31625","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.26261,0.791,0.742,1590,0.808,"SERPINB5, THBS1, IGFBP3, CCNE2, CD82, CCNG2, CDKN2A, SFN, PERP, RRM2, CCNE1",0.129596094720973,0.0925886392254138,FALSE
+"GSE31625","Log2FC","KEGG_PANCREATIC_CANCER",0.41148,1.24,0.192,2000,0.603,"RAC2, TGFA, EGFR, PIK3R3, PIK3CA, VEGFA, CDKN2A, TGFBR2, E2F1, RALBP1, MAPK3, RALGDS, RALA, ERBB2, VEGFB, MAPK1, CDK6, RALB",0.71669877129645,0.219682687859849,FALSE
+"GSE31625","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.24168,0.715,0.853,975,0.912,"DPYD, PPCS",0.069050968832477,0.0400051616715838,FALSE
+"GSE31625","Log2FC","KEGG_PARKINSONS_DISEASE",-0.31637,-0.965,0.47,9495,0.757,"COX7A2L, UQCRB, COX5B, NDUFB8, SLC6A3, NDUFA1, UQCRFS1, SLC25A4, VDAC1, NDUFS1, SLC25A5, NDUFA2, SLC18A2, NDUFA4L2, NDUFS2, COX7B, SLC18A1, NDUFB1, UBA1, NDUFA7, VDAC2, CASP9, APAF1, COX5A, GPR37, VDAC3, SNCA, SLC25A6, UCHL1",0.327902142064283,0.120904120499927,FALSE
+"GSE31625","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.29325,0.895,0.582,914,0.691,"CDH1, FYN, OCLN, TLR4, TLR5",0.235077015350112,0.160521952625802,FALSE
+"GSE31625","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.31894,0.955,0.496,1813,0.676,"CDH1, CBLC, LAMB3, RAC2, LAMC2, TGFA, LAMA3, EGFR, PIK3R3, WNT4, ITGA6, ITGA3, ITGA2, CSF1R, IL6, PIK3CA, BMP2, CCNE2, JUN, VEGFA, LAMA4, PPARG, TCF7L1, WNT5A, MMP1, FGF12, CDKN2A, PDGFB, TGFBR2, WNT7B, FGF9, PPARD, BCR, KIT, WNT7A, LEF1, E2F1, PML, HDAC1, RBX1, RALBP1, MAPK3, RALGDS, WNT5B, SKP2, RARA, DVL3, WNT2, RALA, PDGFA, ERBB2, CCNA1, CCNE1, FZD1, VEGFB, FZD6, BIRC3, MECOM, MMP9, EGLN3, NFKBIA, MMP2, CDKN2B, MAPK1",0.304518323509803,0.170053304058364,FALSE
+"GSE31625","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.40476,-1.26,0.16,12728,0.465,"UGT2B28, UGDH",0.795880017344075,0.332547047110046,FALSE
+"GSE31625","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.41572,-1.26,0.17,11162,0.465,"GPI, PRPS1, FBP2, PFKM, TKT, TALDO1, G6PD, PGD",0.769551078621726,0.332547047110046,FALSE
+"GSE31625","Log2FC","KEGG_PEROXISOME",-0.26862,-0.83,0.682,11595,0.906,"ACOX2, GNPAT, PHYH, ECI2, ACSL4, MLYCD, CRAT, PECR, IDH1, PEX6, EPHX2, SLC27A2, BAAT",0.166215625343521,0.0428718023231869,FALSE
+"GSE31625","Log2FC","KEGG_PHENYLALANINE_METABOLISM",-0.48788,-1.49,0.0748,12309,0.345,"HPD, AOC3, ALDH3B1, DDC, ALDH3A1",1.12609840213554,0.462180904926726,FALSE
+"GSE31625","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.24219,-0.74,0.828,11946,0.913,"CDS2, PIK3CG, PRKCB, DGKI, IMPA1, PLCB1, DGKD, DGKG, PTEN, PLCB4",0.0819696632151199,0.039529222465701,FALSE
+"GSE31625","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.43593,-1.31,0.149,10536,0.474,"COX10, UGT2B15, UROS, HCCS, BLVRB, PPOX, COX15, FECH, UGT2B28, HMOX1",0.826813731587726,0.324221658325915,FALSE
+"GSE31625","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",-0.30238,-0.909,0.53,10970,0.837,"CPT1A, PLTP, EHHADH, ACADL, ACOX2, ACSL4, GK, PCK1, PCK2, FADS2, ME1, SCD, SLC27A5, SLC27A2, FABP6",0.275724130399211,0.07727454200674,FALSE
+"GSE31625","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.50073,-1.51,0.07,13042,0.355,"SLC27A5, AKR1C4, BAAT",1.15490195998574,0.449771646944906,FALSE
+"GSE31625","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.2086,0.628,0.965,1471,1,"IL7R, BLNK, RFXANK, TAP2",0.0154726866562074,0,FALSE
+"GSE31625","Log2FC","KEGG_PRION_DISEASES",0.31992,0.965,0.46,1315,0.677,"FYN, CCL5, IL6, EGR1, MAPK3, PRKACA",0.337242168318426,0.169411331314856,FALSE
+"GSE31625","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.31779,0.959,0.46,1900,0.678,"MAPK13, PIK3R3, RPS6KA2, PIK3CA, MAPK11, MAPK3, GNAI2, PRKACA, CCNA1, ADCY8, MAPK14, CDC25A, CCNA2, MAPK1, ADCY6, RPS6KA1, MAPK12",0.337242168318426,0.168770306132937,FALSE
+"GSE31625","Log2FC","KEGG_PROPANOATE_METABOLISM",-0.56459,-1.68,0.0354,9534,0.325,"ECHS1, ALDH7A1, LDHC, SUCLA2, SUCLG1, HADHA, LDHB, ACSS3, PCCA, EHHADH, ACACA, SUCLG2, HIBCH, ALDH3A2, MLYCD, LDHAL6B, ALDH1B1, ACAT1, ALDH2, ACACB",1.45099673797421,0.488116639021126,FALSE
+"GSE31625","Log2FC","KEGG_PROSTATE_CANCER",0.30932,0.941,0.494,1865,0.664,"TGFA, EGFR, PIK3R3, PDGFC, PIK3CA, CCNE2, TCF7L1, PDGFB, LEF1, E2F1, CREB3L1, MAPK3, PDGFA, ERBB2, CCNE1, NFKBIA, MAPK1, SOS1",0.306273051076353,0.177831920631982,FALSE
+"GSE31625","Log2FC","KEGG_PROTEASOME",-0.1817,-0.554,0.996,8415,1,"PSMD1, PSMC6, PSMD3, PSMC5, PSMA3, PSME3, PSMD13, PSMD14, PSME1, POMP, PSMA4, IFNG, PSMC4, PSMF1, PSMA1, PSMD11, PSMB5",0.00174066157630127,0,FALSE
+"GSE31625","Log2FC","KEGG_PROTEIN_EXPORT",0.26497,0.8,0.731,2532,0.81,"SEC61G, SPCS3, SEC62, SEC61A1",0.13608262304214,0.0915149811213502,FALSE
+"GSE31625","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.40071,-1.2,0.252,12404,0.512,"GLUD2, PCK1, PCK2, FXYD2",0.598599459218456,0.290730039024169,FALSE
+"GSE31625","Log2FC","KEGG_PURINE_METABOLISM",-0.4116,-1.24,0.199,9680,0.486,"IMPDH1, IMPDH2, FHIT, POLR3C, ENTPD2, POLR2A, GUCY2F, ADCY1, ADCY9, PRPS2, NME4, POLE3, PKLR, POLR2D, POLR1E, POLR1B, ENPP3, APRT, POLR2C, RRM1, POLR3G, PRIM1, DGUOK, AK1, NME7, ADCY10, POLR3F, NME1, ITPA, PRPS1, PDE6B, PDE8A, ADPRM, POLA1, POLR3D, NPR1, PDE7B, ADA, PNP, POLR2L, PAPSS2, POLR1D, GMPR2, NPR2, NT5C2, PDE8B, PDE1C, PDE3B, AK5, NT5M, PDE3A, PFAS, NT5C, PDE10A, PDE1A, PDE4D, PDE4B",0.701146923590293,0.313363730737707,FALSE
+"GSE31625","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.24377,-0.758,0.799,9807,0.902,"POLR3C, POLR2A, DHODH, NME4, POLE3, POLR2D, POLR1E, POLR1B, POLR2C, RRM1, POLR3G, CAD, PRIM1, NME7, POLR3F, NME1, ITPA, POLA1, POLR3D, TXNRD1, PNP, POLR2L, POLR1D, NT5C2, NT5M, NT5C",0.0974532206860086,0.0447934624580583,FALSE
+"GSE31625","Log2FC","KEGG_PYRUVATE_METABOLISM",-0.61941,-1.91,0.0101,9330,0.289,"DLD, ALDH7A1, LDHC, HAGH, PDHB, PKLR, GRHPR, PDHA2, LDHB, ACACA, ALDH3A2, ME2, PDHA1, LDHAL6B, ALDH1B1, ACAT1, PCK1, PCK2, ME1, ALDH2, ACACB",1.99567862621736,0.539102157243452,FALSE
+"GSE31625","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.29868,0.909,0.551,1633,0.672,"MYL9, RAC2, PAK6, TIAM1, EGFR, PIK3R3, PDGFC, ITGA6, ITGB2, ITGA3, ITGA2, ITGA4, GSN, ITGB4, PIK3CA, CHRM3, MYH9, LIMK2, FGF12, PDGFB, PAK1, FGF9, MAPK3, ITGB8, BAIAP2, SSH3, VAV2, PDGFA, MYH14, SCIN, ITGA1, PXN, PIP4K2C, SLC9A1",0.258848401148215,0.172630726946175,FALSE
+"GSE31625","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.47475,-1.46,0.0974,10041,0.366,"GABARAP, IFNA7, PIK3C3, IFNG, ULK1, IFNA21, IFNA10, BECN1, PRKAA2, IFNA4, IFNA17, IFNA2, ULK2, ATG7",1.01144104312138,0.436518914605589,FALSE
+"GSE31625","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.38801,1.15,0.241,2044,0.681,"PAK6, TGFA, PIK3R3, PIK3CA, JUN, VEGFA, PDGFB, PAK1, RBX1, MAPK3, VEGFB, EGLN3, MAPK1, SOS1, RAPGEF1, RAP1A",0.617982957425132,0.166852888087215,FALSE
+"GSE31625","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.55001,1.67,0.0366,1528,0.479,"MME, ACE2, ANPEP, CTSA, REN",1.43651891460559,0.319664486585437,FALSE
+"GSE31625","Log2FC","KEGG_RETINOL_METABOLISM",-0.4968,-1.5,0.0742,11825,0.349,"CYP26B1, CYP3A43, ADH6, BCO1, UGT2B28, CYP3A5, ALDH1A1",1.12959609472097,0.45717457304082,FALSE
+"GSE31625","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",-0.27682,-0.84,0.639,9638,0.896,"FLAD1, ENPP3, ACP1, MTMR6, RFK",0.1944991418416,0.0476919903378748,FALSE
+"GSE31625","Log2FC","KEGG_RIBOSOME",-0.50057,-1.53,0.0639,8425,0.373,"RPL14, RPL26L1, RPS12, RPL35, RPL37A, RPS17, RPS24, RPL6, RPS25, RPS27A, RPL32, RPL7, RPS28, RPL23A, RPS27, RPS15, RPL19, RPS19, RPL3, RPS29, RPS7, RPLP0, RPS6, RPL36AL, RPL31, RPS23, RPL27, RPL38, RPLP1, RPL30, RPL36, RPLP2, RPS4X, RPS16, RPS9, RPL10A, RPS11, RPL15, RPL27A, RSL24D1, RPL10L, RPS27L, RPS4Y1",1.1944991418416,0.428291168191312,FALSE
+"GSE31625","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.3546,1.09,0.293,1900,0.633,"MAPK13, ISG15, DDX58, IFIH1, MAP3K1, MAPK11, DHX58, TNF, SIKE1, MAPK14, CYLD, IRF3, IL12A, NFKBIA, MAPK12",0.533132379645891,0.198596289982645,FALSE
+"GSE31625","Log2FC","KEGG_RNA_DEGRADATION",-0.28893,-0.886,0.596,9430,0.825,"LSM8, LSM1, EXOSC8, PARN, WDR61, PAPOLG, PAPOLB, EXOSC2, CNOT7, HSPD1, DIS3, EXOSC5, HSPA9, ENO2, ENO3",0.224753740259764,0.0835460514500749,FALSE
+"GSE31625","Log2FC","KEGG_RNA_POLYMERASE",-0.46002,-1.37,0.114,9807,0.41,"POLR3C, POLR2A, POLR2D, POLR1E, POLR1B, POLR2C, POLR3G, POLR3F, POLR3D, POLR2L, POLR1D",0.943095148663527,0.387216143280265,FALSE
+"GSE31625","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.44495,-1.33,0.16,9883,0.457,"SEPHS1, SCLY, AHCY, MAT1A, CTH, MAT2A, PAPSS2",0.795880017344075,0.34008379993015,FALSE
+"GSE31625","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.26617,0.814,0.708,778,0.794,"LAMB3, LAMC2, LAMA3, PIK3R3, ITGA6, ITGA3, ITGA2, PIK3CA, CCNE2, LAMA4",0.149966742310231,0.100179497572904,FALSE
+"GSE31625","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.2957,0.921,0.537,1271,0.676,"VAMP8, VAMP5, YKT6, STX3, STX5, SNAP29",0.270025714300444,0.170053304058364,FALSE
+"GSE31625","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",-0.43182,-1.3,0.145,12846,0.474,"GLA, GALC, GAL3ST1",0.838631997765025,0.324221658325915,FALSE
+"GSE31625","Log2FC","KEGG_SPLICEOSOME",0.15272,0.469,0.996,3592,1,"TRA2A, BCAS2, HSPA1L, WBP11, SNU13, LSM6, SNRPD3, HSPA2, SNRNP70, DHX38, PPIH, CHERP, NCBP2, HSPA6, DHX16, SRSF8, SF3B3, LSM2, THOC1, XAB2, RBM17, PRPF38B, PUF60, SF3A1, PRPF6, TXNL4A",0.00174066157630127,0,FALSE
+"GSE31625","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.28711,-0.859,0.638,11952,0.878,"GYS2, GBE1, GAA, UGT2B28, MGAM, UGDH",0.195179321278838,0.0565054840938974,FALSE
+"GSE31625","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.29153,0.872,0.61,295,0.727,"DHCR24",0.214670164989233,0.138465589140962,FALSE
+"GSE31625","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.35894,-1.09,0.308,12728,0.578,"UGT2B28, HSD17B8, CYP3A5, AKR1C4, AKR1C3, AKR1C1",0.511449283499556,0.238072161579471,FALSE
+"GSE31625","Log2FC","KEGG_SULFUR_METABOLISM",0.6538,1.99,0.00926,2471,0.257,"SULT1E1, SULT1A2, SULT1A1, SULT2B1, CHST11, CHST12",2.03338901331807,0.590066876668705,FALSE
+"GSE31625","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.31901,-0.959,0.44,10222,0.757,"IL10, CD40LG, GRIN2B, C1QB, IFNG, TRIM21, HLA-DPB1, HLA-DMB, C7, SNRPB, GRIN2A, SSB, C1R, C5, C1S",0.356547323513813,0.120904120499927,FALSE
+"GSE31625","Log2FC","KEGG_TASTE_TRANSDUCTION",-0.24684,-0.755,0.801,12388,0.897,"ASIC2, PRKX, PDE1A",0.0963674839157623,0.0472075569559079,FALSE
+"GSE31625","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.41159,1.24,0.189,83,0.603,"GAD1",0.723538195826756,0.219682687859849,FALSE
+"GSE31625","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.16562,-0.503,0.996,9291,1,"HMGCS2, PMVK, GGPS1, PDSS1, ACAT1",0.00174066157630127,0,FALSE
+"GSE31625","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.25516,-0.793,0.74,11774,0.926,"SMAD6, ID1, ACVR1, E2F5, INHBE, TGFBR1, SMAD2, MYC, BMP6, FST, BMPR1B, ID3, ID2",0.130768280269024,0.0333890133180656,FALSE
+"GSE31625","Log2FC","KEGG_THYROID_CANCER",0.41061,1.22,0.183,1179,0.604,"CDH1, PPARG, TCF7L1, LEF1, MAPK3",0.737548910269571,0.218963061378868,FALSE
+"GSE31625","Log2FC","KEGG_TIGHT_JUNCTION",0.37831,1.15,0.25,1430,0.681,"CLDN4, CLDN7, MYL9, TJP2, PRKCD, F11R, TJP3, PRKCH, OCLN, PRKCZ, MYH9, PARD6B, AFDN, PRKCI, CLDN9, GNAI2, YES1, CLDN3, CLDN8, LLGL2, MYH14",0.602059991327962,0.166852888087215,FALSE
+"GSE31625","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.30439,0.918,0.518,1900,0.672,"MAPK13, PIK3R3, CCL5, IL6, TLR3, PIK3CA, TLR2, TLR4, JUN, TLR5, MAPK11, MAPK3, TAB1, TNF, MAPK14, IRF3, IL12A, NFKBIA, MAPK1, TAB2, MAPK12",0.285670240254767,0.172630726946175,FALSE
+"GSE31625","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",-0.45213,-1.37,0.12,10896,0.41,"MAOA, TDO2, EHHADH, OGDHL, HAAO, ALDH3A2, ALDH1B1, ACAT1, ALDH2, DDC, KYNU",0.920818753952375,0.387216143280265,FALSE
+"GSE31625","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.43248,1.28,0.153,1276,0.698,"HK2, PIK3R3, PRKCD, PRKCZ, PIK3CA, HK1, MAPK3, TNF",0.815308569182401,0.156144577376839,FALSE
+"GSE31625","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.5911,1.81,0.0139,1875,0.367,"GAD1, CPE, HLA-DOB, HLA-C, HLA-B, HLA-DQB1, HLA-A, HLA-DRB1, HLA-E, TNF, HLA-G, HLA-DPA1, HLA-DRA, IL12A, ICA1, HLA-F",1.8569851997459,0.435333935747911,FALSE
+"GSE31625","Log2FC","KEGG_TYROSINE_METABOLISM",-0.45317,-1.39,0.0922,12309,0.43,"HPD, ADH6, AOC3, ALDH3B1, DDC, HGD, ALDH3A1",1.03526907894637,0.366531544420413,FALSE
+"GSE31625","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35907,1.08,0.296,3432,0.627,"MAPK13, CBLC, PAK6, PIK3R3, FYN, PIK3CA, JUN, BCL10, PAK1, MAPK11, MAPK3, TNF, VAV2, DLG1, MAPK14, NFKBIA, MAPK1, SOS1, MAPK12, PTPN6, NFAT5, PPP3CA, VAV1, CBLB, NFATC4, FOS, PAK2, PDPK1, MALT1, RASGRP1, RELA, PDCD1, NRAS, LCK, CTLA4, CSF2, PIK3R2, NCK2, PLCG1, KRAS",0.528708288941061,0.202732459169284,FALSE
+"GSE31625","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.28291,0.866,0.622,2675,0.73,"CBLC, SMURF2, FBXO2, MAP3K1, NEDD4L, ITCH, UBE2L6, CDC20, FBXW7, PML, RBX1, SKP2, UBE2E3, UBE2C, CUL7, BIRC3, UBE2D4, UBE2G2, SMURF1, SOCS1, CBLB, BIRC2, PIAS3, UBE2H, UBE3A, UBR5",0.206209615309181,0.136677139879544,FALSE
+"GSE31625","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.68608,-2.09,0.00864,9323,0.418,"IARS2, PDHB, BCAT2, PDHA2, PDHA1, BCAT1",2.06348625752111,0.378823718224965,FALSE
+"GSE31625","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.29026,-0.89,0.584,9291,0.828,"HMGCS2, DLD, ECHS1, ALDH7A1, BCKDHA, AUH, HADHA, ACAA2, BCAT2, PCCA, EHHADH, HIBCH, ALDH3A2, ACADSB, HSD17B10, ACADS, BCAT1, ALDH1B1, ACAT1, ALDH2",0.233587152887601,0.0819696632151199,FALSE
+"GSE31625","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.23446,-0.711,0.88,11756,0.939,"PRKCQ, ACTA2, PRKCB, MYLK3, NPR1, ADRA1D, MYLK, AGTR1, CALCRL, NPR2, PLCB1, PRKX, PLCB4, PLA2G4A",0.0555173278498314,0.0273344077338891,FALSE
+"GSE31625","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.36455,1.1,0.304,1843,0.64,"ARHGDIB, CREB3L1, PRKACA, AQP3, DCTN5, ADCY6",0.517126416391246,0.193820026016113,FALSE
+"GSE31625","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.30368,0.913,0.529,2204,0.673,"MAPK13, RAC2, PIK3R3, HSPB1, PIK3CA, PLA2G12A, VEGFA, MAPK11, MAPK3, MAPKAPK3, PXN, MAPK14, MAPK1, MAPK12, MAPKAPK2, NFAT5, PPP3CA",0.276544327964814,0.171984935776023,FALSE
+"GSE31625","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.27459,0.83,0.686,2781,0.782,"TJP2, SEC61G, KDELR3, ATP6V0A4, PRKACA, KDELR2, ERO1A, GNAS, ATP6V0D1, SEC61A1, KDELR1, ATP6V0C",0.163675884293248,0.106793246940152,FALSE
+"GSE31625","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.45369,1.37,0.123,1875,0.622,"RAC2, FYN, ICAM1, HLA-DOB, ITGB2, HLA-C, HLA-B, MYH9, HLA-DQB1, CXADR, HLA-A, HLA-DRB1, DMD, HLA-E, MYH14, HLA-G, DAG1, HLA-DPA1, HLA-DRA, HLA-F",0.910094888560602,0.206209615309181,FALSE
+"GSE31625","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.26401,0.798,0.723,1952,0.804,"RAC2, DAAM1, WNT4, CSNK1E, CAMK2G, CTNNBIP1, JUN, TCF7L1, WNT5A, VANGL1, WNT7B, PPARD, WNT7A, LEF1, RBX1, TBL1XR1, WNT5B, DVL3, PRKACA, WNT2, FOSL1, LRP5, SENP2, FZD1, FZD6, PPP2R5C, PPP2R5B, CSNK2B, TBL1Y",0.140861702705469,0.0947439512515487,FALSE
+"Coldren et al","Log2FC","KEGG_ABC_TRANSPORTERS",0.23561,0.688,0.916,7191,0.992,"ABCA12, ABCB8, ABCB9, ABCA13, ABCD1, ABCC3, ABCA1, ABCA2, ABCB11, ABCC10, ABCD4, ABCA4, ABCC5, ABCA5, TAP2, ABCC11, ABCG1, ABCB6, ABCG2",0.0381045263321496,0.00348832784582135,FALSE
+"Coldren et al","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36169,1.05,0.351,5916,0.767,"PIK3R2, IKBKB, MAPK3, RPS6KB2, PML, RARA, PIK3CA, JUP, STAT5B, STAT3, BRAF, RELA, TCF7L1, RUNX1, BAD, PIM1, PIK3R3, CCNA1, STAT5A, MAPK1, PIK3R5, PIK3CB, CEBPA",0.454692883534176,0.115204636051019,FALSE
+"Coldren et al","Log2FC","KEGG_ADHERENS_JUNCTION",0.36058,1.03,0.404,3562,0.786,"NECTIN1, CTNND1, CDH1, ERBB2, BAIAP2, NECTIN4, PTPN1, RAC2, MAPK3, INSR, PTPN6, SNAI2, MET, IGF1R, EP300, EGFR, PTPRF, TCF7L1, PTPRB, SRC",0.393618634889395,0.104577453960592,FALSE
+"Coldren et al","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.27558,0.803,0.768,5975,1,"TRADD, RXRA, CPT1B, PPARA, IKBKB, ACSL1, RXRB, CPT1C, ADIPOR1, IRS2, STAT3, PRKAA1, RELA, ACSL3, PRKAG2, PRKAB2, ACSL5, ACSL6, SLC2A1, MAPK10, IRS1, NFKBIA",0.114638779968488,0,FALSE
+"Coldren et al","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.44972,1.3,0.115,3496,0.845,"GLUL, AGXT, GLS2, ASL, ABAT, ASS1, GPT, NIT2, IL4I1",0.939302159646388,0.0731432910503077,FALSE
+"Coldren et al","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.37286,1.09,0.336,5894,0.732,"PIK3R2, SCNN1A, MAPK3, INSR, PIK3CA, SFN, SCNN1G, IRS2, NEDD4L, PIK3R3, SCNN1B, HSD11B2, MAPK1, PIK3R5, IRS1, PIK3CB",0.473660722610156,0.135488918941608,FALSE
+"Coldren et al","Log2FC","KEGG_ALLOGRAFT_REJECTION",-0.23407,-0.825,0.717,16990,0.974,"PRF1, IL5",0.1444808443322,0.0114410431213845,FALSE
+"Coldren et al","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.40981,1.18,0.194,3971,0.74,"PLA2G12A, PLA2G6, PLA2G4B, PLA2G10, PLA2G4E, ACOX1, PLA2G2C",0.712198270069774,0.130768280269024,FALSE
+"Coldren et al","Log2FC","KEGG_ALZHEIMERS_DISEASE",0.24418,0.71,0.901,6624,0.999,"NDUFV1, CAPN1, CACNA1D, GRIN1, ATP2A3, CALML3, COX5B, LRP1, ATP5F1E, NDUFB7, MAPK3, CDK5, FADD, NDUFS8, EIF2AK3, NDUFA3, NDUFV2, COX6C, UQCR10, GRIN2A, APH1A, COX6B2, GRIN2D, CHP1, PPP3CA, SDHD, ADAM10, BAD, UQCR11, GNAQ, NDUFB4, NDUFAB1, APOE, CALML6, UQCRB, BACE2, NDUFA6, UQCRHL, ITPR3, NDUFA5, UQCRC1, NDUFB5, BID, MAPK1, CACNA1F, UQCRFS1, UQCRC2, PLCB3, COX6A1, GSK3B, NDUFA2, SNCA, APP, ERN1, CAPN2, ATP5PD, GRIN2C, NOS1, CHP2",0.045275209020937,0.000434511774017692,FALSE
+"Coldren et al","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.55987,-1.88,0.0192,17343,0.262,"IARS2, MARS2, FARS2, FARSB, WARS2, RARS2, PSTK, YARS2",1.71669877129645,0.581698708680255,FALSE
+"Coldren et al","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51252,1.48,0.0387,5085,0.535,"HK2, MPI, GMPPA, NANP, GCK, PGM1, GMPPB, NPL, NAGK, GALT, CYB5R1, NANS, FPGT, HK1, GALE, UXS1, CYB5R3, HEXB, GNPDA1, AMDHD2, PGM2",1.41228903498109,0.271646217978772,FALSE
+"Coldren et al","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28452,0.821,0.756,4515,1,"CAT, CCS, CASP1, MAPK13, GRIN1, GRIN2A, GPX1, GRIN2D, CHP1, MAPK11, PPP3CA, BAD, MAP3K5",0.121478204498793,0,FALSE
+"Coldren et al","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26803,0.783,0.802,4719,1,"RFXANK, IFI30, TAPBP, CALR, CD74, CTSS, LGMN, CTSB, HSPA1B, B2M, CIITA, PDIA3, PSME1, CD4",0.0958256317158365,0,FALSE
+"Coldren et al","Log2FC","KEGG_APOPTOSIS",0.28433,0.827,0.755,6624,1,"TRADD, IL1RAP, CAPN1, PIK3R2, ENDOD1, IKBKB, PIK3CA, MYD88, FADD, TNFSF10, CASP10, RELA, CHP1, PPP3CA, IRAK4, BAD, ENDOG, PIK3R3, NGF, PRKACA, IL1A, BID, CSF2RB, BAX, PIK3R5, PIK3CB, IL1R1, NFKBIA, PRKAR1B, DFFA, CAPN2, BCL2L1, CHP2",0.122053048370812,0,FALSE
+"Coldren et al","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.38876,1.13,0.274,2694,0.707,"PLA2G12A, CYP4F3, CYP2E1, PTGES, PLA2G6, GGT7, PLA2G4B, LTC4S, PTGES2, EPHX2, CYP2J2, CYP4A22, PTGS1, PLA2G10, PLA2G4E, ALOX12B",0.562249437179612,0.150580586203101,FALSE
+"Coldren et al","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31866,0.927,0.564,5717,0.941,"GLUL, PYCR3, CKMT1A, CKMT1B, SAT2, NOS3, GLS2, ASL, ASS1, OAT, GATM, P4HA2, NAGS, PRODH, P4HA1, MAOA, AZIN2, ALDH4A1, GAMT",0.248720896016658,0.0264103765727431,FALSE
+"Coldren et al","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.3651,1.06,0.339,3482,0.769,"ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, JUP, DSP, ITGA3, CACNB2, DAG1, DSG2, ITGA2B, DSC2, TCF7L1, PKP2",0.469800301796918,0.114073660198569,FALSE
+"Coldren et al","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.50501,-1.8,0.00952,14596,0.187,"UGDH, MIOX, ALDH3A2, UGT2A1, ALDH1B1, ALDH7A1, ALDH9A1",2.02136305161553,0.728158393463501,TRUE
+"Coldren et al","Log2FC","KEGG_ASTHMA",-0.34369,-1.22,0.202,17122,0.484,"IL13, EPX, IL5",0.694648630553376,0.315154638355588,FALSE
+"Coldren et al","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.42092,-1.5,0.0333,16806,0.275,"IFNA21, PRF1, IFNA13, IL5, CTLA4",1.47755576649368,0.560667306169737,FALSE
+"Coldren et al","Log2FC","KEGG_AXON_GUIDANCE",0.44776,1.29,0.118,5666,0.806,"EPHA1, PAK6, PLXNB2, EPHB3, PLXNB1, PLXNA3, SEMA4A, EFNA1, FES, SEMA3E, EFNA4, SEMA4B, RAC2, LIMK2, SEMA7A, EFNA3, SRGAP3, MAPK3, NTN4, RHOD, UNC5B, NTN1, PLXNB3, CDK5, EPHB4, MET, PLXNA2, EPHB6, SEMA3B, ABLIM3, NCK2, EPHB2, SEMA4F, SRGAP1, UNC5A, ABLIM2, EFNB3, EFNB1, ABLIM1, SEMA5B, CHP1, PPP3CA, PAK2, SEMA4C, SEMA4D, NGEF, SEMA3C, LIMK1, NCK1, SEMA5A, RASA1, RND1, ROBO3, RAC1, PAK1, PAK4, MAPK1, NFATC1",0.928117992693875,0.0936649581949093,FALSE
+"Coldren et al","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.3741,1.09,0.322,4115,0.732,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, WNT4, DVL3, BMP2, WNT10A, GLI3, TCF7L1, FZD4, DVL2, WNT11",0.492144128304169,0.135488918941608,FALSE
+"Coldren et al","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36638,-1.28,0.129,18395,0.482,"TBPL1, TAF9B, TBP, GTF2H2, TAF9, TAF1L",0.889410289700751,0.31695296176115,FALSE
+"Coldren et al","Log2FC","KEGG_BASE_EXCISION_REPAIR",0.30931,0.899,0.639,912,0.957,"SMUG1, POLD4, POLB",0.1944991418416,0.0190880622231565,FALSE
+"Coldren et al","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.24897,-0.871,0.593,17472,0.913,"ALDH1B1, ALDH7A1, SMS, ALDH9A1",0.226945306635737,0.039529222465701,FALSE
+"Coldren et al","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.30636,0.88,0.662,3986,0.967,"ACOT4, TECR, ACAA1, ELOVL6, ACOX1, SCD5",0.1791420105603,0.0145735259169983,FALSE
+"Coldren et al","Log2FC","KEGG_BLADDER_CANCER",0.38783,1.12,0.297,4516,0.712,"CDH1, ERBB2, MMP9, TYMP, VEGFB, MAPK3, EGFR, E2F1, DAPK1, THBS1, FGFR3, BRAF, PGF, VEGFA, DAPK2",0.527243550682788,0.147520006363144,FALSE
+"Coldren et al","Log2FC","KEGG_BUTANOATE_METABOLISM",0.28276,0.818,0.756,2472,1,"ABAT, HMGCL, BDH1, HMGCS1, ACADS, EHHADH",0.121478204498793,0,FALSE
+"Coldren et al","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39615,1.15,0.235,6959,0.71,"VAV1, BLNK, PIK3R2, PLCG2, DAPP1, RAC2, VAV3, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, IFITM1, CD72, CD79A, RELA, CD19, CHP1, PPP3CA, LYN, PIK3R3, RAC1, MAPK1, NFATC1, PIK3R5, PIK3AP1, PIK3CB, NFKBIA, GSK3B, FOS, SYK, NFATC4, GRB2, CHP2, INPP5D, BCL10, CD22",0.628932137728264,0.148741651280925,FALSE
+"Coldren et al","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.29926,0.875,0.651,4406,0.97,"DRD5, PTAFR, BDKRB2, ERBB2, P2RX4, PLCG2, GNA15, CACNA1D, ERBB3, GRIN1, PLCD1, ATP2A3, CALML3, NOS3, CAMK2G, ADORA2B, ADORA2A, CACNA1I, ADCY4, BDKRB1, RYR1, PTK2B, EGFR, ATP2B4, SLC8A2, GRIN2A, PLCG1, SPHK2, PHKG1, ADRB2, GRIN2D, CHP1, P2RX6, PPP3CA, EDNRA, TNNC1, GNAS, GNAQ, P2RX2, LTB4R2, HTR7",0.186419011431808,0.0132282657337552,FALSE
+"Coldren et al","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27818,0.805,0.783,6162,1,"TNNI3, CACNA1D, CACNG1, COX5B, CACNB3, CACNG4, CACNB2, COX6C, UQCR10, COX6B2, TNNT2, TNNC1, SLC9A1, UQCR11, UQCRB, UQCRHL, UQCRC1, CACNA1F, UQCRFS1, UQCRC2, COX6A1",0.106238237942057,0,FALSE
+"Coldren et al","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.37321,1.07,0.33,3535,0.748,"CDH3, NECTIN1, CDH1, CLDN8, ITGB2, CLDN9, CLDN7, CLDN4, F11R, ITGB8, CDH5, SDC1, ICOSLG, SDC4, CLDN18, ICAM3, CD6, GLG1, CLDN11, CD40, SELL, PTPRF, CLDN23, CD276, CLDN3",0.481486060122112,0.126098402135539,FALSE
+"Coldren et al","Log2FC","KEGG_CELL_CYCLE",-0.36349,-1.25,0.182,15880,0.498,"ORC1, MCM4, PTTG2, CCNA2, ORC6, SMAD4, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, MCM3, ANAPC10, CDK6, CDC20, CDK1, SMC1A, CCNH, CCNB3, CDKN2C, CDC25A, TGFB1, ORC4, CCNB1, MCM6, PRKDC, TTK, CDC14A, CDKN2B, E2F2, BUB3, ORC2, CDC7, PTTG1, YWHAQ, HDAC2, SMC3, E2F5, ORC3, CDKN2A, E2F3, SMAD2, ANAPC13",0.739928612014925,0.302770657240282,FALSE
+"Coldren et al","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.31904,0.922,0.585,4742,0.945,"CCR3, PRKCD, CCL22, STAT2, GRK7, VAV1, PIK3R2, FOXO3, GRK2, CX3CL1, RAC2, VAV3, CCL17, JAK3, CXCL10, IKBKB, MAPK3, CCL28, CCR2, ARRB1, VAV2, CCR7, ADCY5, PIK3CA, ADCY4, CXCL11, CXCL16, CCL5, PTK2B, STAT5B, RAP1A, CXCL9, CXCR2, STAT3, BRAF, ADCY6, RELA, TIAM1, PXN, GNB2, TIAM2, CCL26, CCL19, CXCL3, PRKCZ, CXCR6, WASL, LYN, PIK3R3, STAT1, CCR1",0.23284413391782,0.0245681914907371,FALSE
+"Coldren et al","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.24297,0.702,0.913,6797,0.985,"CBLC, BCR, PIK3R2, IKBKB, MAPK3, PIK3CA, STAT5B, E2F1, CBLB, BRAF, CDKN1B, RELA, MECOM, RUNX1, BAD, PIK3R3, TGFB3, CRKL, STAT5A, TGFBR2, MAPK1, PIK3R5, PIK3CB, NFKBIA, CDKN1A, BCL2L1, GRB2, CTBP1, CCND1",0.039529222465701,0.00656376950238827,FALSE
+"Coldren et al","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.41491,1.22,0.171,4027,0.678,"BHLHE41, NR1D1, CSNK1E, BHLHE40, PER3",0.767003889607846,0.168770306132937,FALSE
+"Coldren et al","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29489,0.858,0.717,7287,0.984,"PC, IDH2, ACO2, IDH3B, SDHD, OGDHL, MDH1, MDH2, OGDH, IDH3G, IDH1, SUCLG2, SDHA",0.1444808443322,0.00700490156865849,FALSE
+"Coldren et al","Log2FC","KEGG_COLORECTAL_CANCER",-0.17873,-0.589,0.988,14592,0.99,"KRAS, RAF1, LEF1, CASP9, BIRC5, AKT2, MAPK9, BCL2, MSH6, CASP3, MSH3, RHOA, APPL1, APC2, AKT3, SMAD4, PIK3R1, PIK3CG, MSH2, APC, TGFB1, TCF7, MAPK8, AXIN2, SMAD2",0.00524305541237188,0.00436480540245009,FALSE
+"Coldren et al","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.26321,0.769,0.844,6969,1,"BDKRB2, F3, BDKRB1, VWF, FGA, FGG, CFB, PROC, C3, PLAU, CD59, SERPINA5, C2, PLAT, SERPINA1, C9, C1R, CFI, F8, CD55, C4A, SERPINF2, F12, FGB",0.073657553374345,0,FALSE
+"Coldren et al","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.22246,-0.752,0.817,15262,1,"BHMT, ADI1, MTR, CDO1, GOT2, SRM, LDHB, MAT2A, AMD1, SMS, MTAP, TRDMT1",0.0877779434675845,0,FALSE
+"Coldren et al","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33412,0.957,0.512,5572,0.883,"CCR3, IFNL3, IFNL1, CSF1R, CCL22, TNFSF13, IFNL2, IL1RAP, CRLF2, TNFRSF21, PDGFA, IL9R, BMP7, CX3CL1, TNFRSF18, CCL17, IL4R, VEGFB, CXCL10, LTBR, CCL28, CCR2, IFNLR1, EPOR, IFNB1, PDGFB, BMP2, CCR7, FLT3LG, MET, CXCL11, CXCL16, CCL5, TNFRSF25, EGFR, CTF1, ACVR1B, IL18, CD40, IL12B, CXCL9, TNFSF10, CXCR2, TNFRSF14, CLCF1, IL7R, EPO, CCL26, IL20RB, IL6R, IL6, NGFR, CCL19, CXCL3, IL20RA, TNFSF18, CXCR6, VEGFA, CSF2, TNFRSF12A, IL15RA, CCR1, LTB, IL12A, IL1R2, PRLR, TGFB3, CSF1, GH2, OSMR, INHBB, IL1A, VEGFC, EDAR, IFNGR1, TGFBR2, CXCL6, IL17RA, CSF2RB",0.290730039024169,0.0540392964224314,FALSE
+"Coldren et al","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.36654,1.07,0.347,3908,0.748,"CASP1, MAVS, RIPK3, IRF3, CXCL10, IKBKB, IFNB1, CCL5, DDX58, IL18, PYCARD, RELA, IKBKE, IL6",0.459670525209126,0.126098402135539,FALSE
+"Coldren et al","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.30112,0.873,0.669,4386,0.966,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ADCY5, ADCY4, ITGA3, CACNB2, DAG1, ITGA2B, ADCY6, TNNT2, TNNC1, GNAS, ITGA2",0.174573882232177,0.0150228735845067,FALSE
+"Coldren et al","Log2FC","KEGG_DNA_REPLICATION",-0.44719,-1.57,0.0333,15778,0.271,"DNA2, RFC2, MCM4, RFC5, MCM3, RNASEH1, PRIM1, MCM6, RNASEH2B, PRIM2, POLE3, RFC1, RPA2, POLA1",1.47755576649368,0.567030709125594,FALSE
+"Coldren et al","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.4409,1.28,0.131,5751,0.746,"ETV7, ETS2, MAPK3, ETV6, EGFR, NOTCH3, PIWIL2, NOTCH1, MAPK1, SPIRE1, SPIRE2",0.882728704344236,0.127261172527331,FALSE
+"Coldren et al","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47037,1.36,0.0814,3662,0.727,"ADH7, ALDH3B2, GSTK1, CYP2E1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, FMO4, MGST2, CYP2D6, UGT2B17, MGST3",1.0893755951108,0.138465589140962,FALSE
+"Coldren et al","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.40437,1.17,0.221,3623,0.738,"XDH, TYMP, NAT1, UCKL1, CES2, UPP1, TK1, CDA, UGT2B17, TPMT, GUSB, ITPA",0.655607726314889,0.131943638176958,FALSE
+"Coldren et al","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.39479,1.15,0.246,4629,0.71,"CHAD, LAMA3, ITGB6, LAMB3, ITGB8, SDC1, SDC4, CD47, TNC, LAMC2, GP6, ITGB4, CD44, AGRN, THBS3, VWF, ITGA3, DAG1, THBS1, ITGA2B, COL1A1, LAMA5, LAMB1, ITGA2, COL5A1, HSPG2",0.609064892896621,0.148741651280925,FALSE
+"Coldren et al","Log2FC","KEGG_ENDOCYTOSIS",0.41396,1.2,0.194,5701,0.69,"EPN3, CHMP4B, CBLC, PSD4, CSF1R, ITCH, TRAF6, RAB11FIP4, CHMP2B, GRK7, FGFR2, RAB22A, PLD1, ARFGAP1, CHMP2A, GRK2, RAB5B, ARAP1, ERBB3, TFRC, ACAP1, EHD2, PLD2, SMURF1, VPS37C, ARRB1, CHMP5, PRKCI, CHMP3, RAB11FIP1, MET, MVB12A, SH3GLB2, IGF1R, CHMP6, VPS28, ARAP2, PARD6B, EGFR, EPN1, ARFGAP3, VPS37B, FGFR3, LDLRAP1, CXCR2, ARFGAP2, CBLB, EPS15, AP2M1, ADRB2, SRC, HSPA1B, CHMP4C, RAB11FIP5, AGAP1, ACAP2, PRKCZ, AP2A1, NEDD4L, ARAP3, PIP5K1C, STAMBP, CHMP1B, LDLR, ASAP2, HSPA2, IQSEC1, DNM2, RAB11B, RAB31, ARF6, RAB5C, VPS25, STAM2",0.712198270069774,0.161150909262745,FALSE
+"Coldren et al","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.26466,0.764,0.834,3392,0.997,"CDH1, ERBB2, PIK3R2, FOXO3, MAPK3, PIK3CA, EGFR, BRAF, TCF7L1",0.0788339493622613,0.00130484168834428,FALSE
+"Coldren et al","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.38362,1.11,0.297,6354,0.707,"MAPK13, PLCG2, F11R, ATP6V1C2, ATP6V0D2, ATP6V1B1, ATP6V1F, IKBKB, MET, CCL5, EGFR, ATP6AP1, CXCR2, PLCG1, RELA, SRC, MAPK11, NOD1, ADAM10, TCIRG1, LYN, ATP6V1G1, ATP6V0A4, RAC1, PAK1, MAPK10, ATP6V1C1, NFKBIA, TJP1, ATP6V1E1, IGSF5",0.527243550682788,0.150580586203101,FALSE
+"Coldren et al","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.39525,1.15,0.231,5894,0.71,"GAB1, PAK6, CBLC, ERBB2, PIK3R2, PLCG2, ERBB3, CAMK2G, MAPK3, RPS6KB2, PIK3CA, NCK2, EGFR, STAT5B, BTC, CBLB, BRAF, PLCG1, CDKN1B, SRC, TGFA, PAK2, AREG, BAD, PIK3R3, NCK1, CRKL, STAT5A, PAK1, PAK4, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB",0.636388020107856,0.148741651280925,FALSE
+"Coldren et al","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.38786,1.11,0.289,3971,0.707,"PLA2G12A, PLD1, PLA2G6, PLA2G4B, PLD2, LPCAT2, PLA2G10, PLA2G4E, PLPP3, LPCAT4, PLA2G2C",0.539102157243452,0.150580586203101,FALSE
+"Coldren et al","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38078,1.11,0.292,3627,0.707,"ADH7, ACAA1, CPT1B, GCDH, CYP4A22, ACSL1, CPT2, CPT1C, ACADS, EHHADH, ACOX1, ACSL3",0.534617148551582,0.150580586203101,FALSE
+"Coldren et al","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.33886,0.966,0.508,2596,0.886,"PRKCD, PLA2G12A, VAV1, MAPK13, PIK3R2, PLCG2, RAC2, VAV3, PLA2G6, PLA2G4B, MAPK3, VAV2, PIK3CA, PLA2G10, PLA2G4E",0.294136287716081,0.0525662781129492,FALSE
+"Coldren et al","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.40295,1.16,0.24,5894,0.755,"PRKCD, VAV1, PLD1, PIK3R2, PLCG2, RAC2, VAV3, LIMK2, PLA2G6, PLA2G4B, PLA2G4F, PLD2, MAPK3, RPS6KB2, VAV2, MARCKS, GSN, PIK3CA, PLA2G4E, PLCG1, PLPP3, SPHK2, WASL, LYN, PIK3R3, PIP5K1C, SPHK1, LIMK1, CRKL, SCIN, ASAP2, MYO10, DNM2, RAC1, PAK1, ARF6, MAPK1, PIK3R5, PIK3CB",0.619788758288394,0.122053048370812,FALSE
+"Coldren et al","Log2FC","KEGG_FOCAL_ADHESION",0.30588,0.881,0.639,6359,0.975,"PAK6, CHAD, ERBB2, LAMA3, VAV1, ITGB6, PDGFA, PIK3R2, LAMB3, ITGB8, RAC2, VAV3, VEGFB, TNC, LAMC2, ITGB4, MAPK3, PPP1CA, VAV2, PDGFB, PIK3CA, PPP1CB, MET, IGF1R, THBS3, VWF, PDGFD, ITGA3, EGFR, RAP1A, THBS1, ITGA2B, BRAF, CAV2, PXN, COL1A1, SRC, CAV1, MYL9, ARHGAP35, PAK2, LAMA5, BAD, PGF, LAMB1, ITGA2, COL5A1, VEGFA, RASGRF1, PIK3R3, PIP5K1C, CRKL, MYL7, ARHGAP5, VEGFC, RAC1, PAK1, BCAR1, PAK4, MAPK1, MAPK10, PIK3R5, PIK3CB, PTEN, COL1A2, ITGA5, TLN2, GSK3B, COL6A1, DIAPH1, ITGA4, CAPN2",0.1944991418416,0.0109953843014632,FALSE
+"Coldren et al","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.42522,1.24,0.153,5764,0.691,"ALPP, QDPR, SPR, FPGS",0.815308569182401,0.160521952625802,FALSE
+"Coldren et al","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5816,1.69,0.0144,3752,0.369,"ALDOC, PFKFB2, HK2, MPI, GMPPA, FBP1, GMPPB, PFKL, FBP2, MTMR1, FPGT, HK1, PFKFB4, ALDOA",1.84163750790475,0.43297363384094,FALSE
+"Coldren et al","Log2FC","KEGG_GALACTOSE_METABOLISM",0.52612,1.53,0.0302,3636,0.483,"HK2, GCK, GAA, PGM1, PFKL, B4GALT1, GALT, GANC, HK1, B4GALT2, GLB1, GALE",1.51999305704285,0.316052869248488,FALSE
+"Coldren et al","Log2FC","KEGG_GAP_JUNCTION",-0.17017,-0.6,0.991,15556,1,"ADRB1, TUBB3, ITPR2, MAP2K5, ADCY7, PRKX, TUBA1B, TUBB, GNAI1, ITPR1, TUBAL3, PRKACB, CDK1, PLCB4, PDGFRA, TUBA1A, NRAS, TUBB4A, TUBB2B, TUBB2A",0.00392634551472468,0,FALSE
+"Coldren et al","Log2FC","KEGG_GLIOMA",0.26293,0.763,0.836,3686,0.991,"PDGFA, PIK3R2, PLCG2, CALML3, CAMK2G, MAPK3, PDGFB, PIK3CA, IGF1R, EGFR, E2F1, BRAF, PLCG1, TGFA",0.0777937225609836,0.00392634551472468,FALSE
+"Coldren et al","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.33643,0.975,0.488,4600,0.87,"GSTK1, GGT7, GSTT2, GSTO2, GSS, IDH2, GSTZ1, GSTA3, OPLAH, MGST2, GGT6, GPX1, MGST3, ANPEP, G6PD, GPX3",0.311580177997289,0.0604807473813815,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.17981,0.521,0.997,5968,0.997,"DGKA, LIPG, DGAT1, MGLL, TKFC, PLPP3, CEL, DGKH, AGPAT2, PNPLA3, DGKI, AWAT2, MBOAT1, DGKE",0.00130484168834428,0.00130484168834428,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.36747,1.07,0.344,5053,0.748,"PISD, CDS1, PLA2G12A, CHKB, DGKA, PLD1, PLA2G6, PLA2G4B, PLD2, PCYT2, CHKA, LPCAT2, ETNK2, CDS2, PLA2G10, PLA2G4E, PLPP3, MBOAT7, LPCAT4, PLA2G2C, DGKH, AGPAT2, PGS1, LPCAT3, LYPLA2, ACHE, PCYT1A, DGKI",0.46344155742847,0.126098402135539,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31093,0.907,0.612,6983,0.956,"AGXT, GCAT, AOC2, GATM, SARDH, SHMT1, MAOA, AMT, GAMT, CTH, SDS, GNMT, AOC3, ALAS2, SRR",0.213248577854439,0.0195421077238999,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.4334,1.25,0.143,1880,0.723,"LDHC, ADH7, ACSS2, ALDH3B2, ALDOC, HK2, ALDH1A3, GCK, ALDH3B1, FBP1, PGM1, GALM, PFKL",0.844663962534938,0.140861702705469,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.43624,1.25,0.16,4160,0.723,"B4GALT7, CHPF, CHST12, XYLT2, CHST14, XYLT1, CHPF2, CHST11, CHST15",0.795880017344075,0.140861702705469,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.45434,1.32,0.0981,3529,0.802,"B4GALT7, EXT1, HS3ST1, XYLT2, HS6ST1, NDST1, HS6ST2, XYLT1",1.00833099262005,0.0958256317158365,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66703,1.93,0.0022,3600,0.282,"B3GNT7, CHST6, B4GALT4, B4GALT1, B3GNT2, CHST4, ST3GAL1, B4GALT2",2.65757731917779,0.549750891680639,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.5591,1.61,0.0142,4196,0.378,"HGSNAT, NAGLU, HPSE, HYAL4, IDS, GALNS, HYAL2, GUSB, GLB1, HEXB",1.84771165561694,0.422508200162775,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.42593,1.24,0.158,6306,0.691,"ST6GALNAC5, B3GALT4, SLC33A1, ST3GAL1, GLB1, HEXB, ST6GALNAC6, ST6GALNAC4, HEXA, ST8SIA1",0.801342913045577,0.160521952625802,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.58271,1.68,0.0122,4276,0.327,"FUT2, FUT1, NAGA, B3GALNT1, ST3GAL1, GBGT1, A4GALT, HEXB, B3GALT5",1.91364016932525,0.485452247339714,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.59777,1.74,0.00987,3600,0.327,"B3GNT3, ABO, FUT3, FUT2, B4GALT4, B3GNT5, B3GNT4, B4GALT1, FUT1, B3GNT2, ST3GAL4, B4GALT2",2.00568284733036,0.485452247339714,FALSE
+"Coldren et al","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50004,1.44,0.0522,3611,0.622,"PIGT, PIGU, GPAA1, PIGZ, PIGV, PIGQ, PIGL, PIGX, PIGS",1.28232949699774,0.206209615309181,FALSE
+"Coldren et al","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.50461,-1.76,0.031,16224,0.183,"HYI, MTHFD2L, MTHFD2, ACO1, CS, MTHFD1L, HAO2",1.50863830616573,0.737548910269571,TRUE
+"Coldren et al","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34964,1,0.444,2596,0.835,"PRKCD, PLA2G12A, MAPK13, PLD1, CACNA1D, PLA2G6, CALML3, PLA2G4B, MAP3K4, PLD2, CAMK2G, MAPK3, MAP3K1, ADCY5, CGA, ADCY4, MMP14, PTK2B, PLA2G10, EGFR, PLA2G4E",0.35261702988538,0.0783135245163979,FALSE
+"Coldren et al","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.20626,-0.725,0.875,3907,1,"IL6, IL1A, KLRC1, KIR2DL1, IL1B, KIR2DL3, KIR3DL2, CD86, FAS, CD80, IFNG, CD28, TNF, KLRD1, GZMB, FASLG, IL2, PRF1",0.0579919469776868,0,FALSE
+"Coldren et al","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36379,1.05,0.391,2621,0.767,"WNT3A, WNT9A, WNT7B, BMP7, WNT7A, WNT4, BMP2, CSNK1E, WNT10A, CSNK1A1, GLI3",0.407823242604133,0.115204636051019,FALSE
+"Coldren et al","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.38485,1.14,0.254,6109,0.73,"CSF1R, IL9R, IL4R, TFRC, EPOR, FLT3LG, CD44, ITGA3, CD9, ITGA2B, CD19, IL7R, EPO, IL6R, IL6, ANPEP, CD59, ITGA2, CSF2, CD4, IL1R2, CSF1, IL1A, IL1R1, CD1D, CD55, ITGA5",0.595166283380062,0.136677139879544,FALSE
+"Coldren et al","Log2FC","KEGG_HISTIDINE_METABOLISM",0.35152,1.02,0.403,1584,0.795,"ALDH3B2, HEMK1, HAL, ALDH1A3, ALDH3B1",0.39469495385889,0.0996328713435297,FALSE
+"Coldren et al","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.23381,0.678,0.928,764,0.986,"POLD4, SEM1",0.0324520237811379,0.0061230850587888,FALSE
+"Coldren et al","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.17121,-0.606,1,16664,1,"ITPR1, NDUFS4, BBC3, AP2S1, SOD1, COX6B1, COX7A2, DCTN4, AP2A2, PLCB4, ATP5F1C, NDUFA9, VDAC2, POLR2E, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, HDAC2, HIP1, TBPL1, TBP, UCP1, ATP5F1A, POLR2D, BDNF, NDUFS5, TFAM, GRIN2B",0,0,FALSE
+"Coldren et al","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30969,0.901,0.626,4437,0.962,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ITGA3, CACNB2, DAG1, ITGA2B, PRKAA1, ACE, TNNT2, IL6, TNNC1, ITGA2, PRKAG2",0.20342566678957,0.0168249279621871,FALSE
+"Coldren et al","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30094,0.869,0.684,6116,0.966,"PLCG2, INPP4B, PLCD1, INPP4A, ALDH6A1, PIK3CA, PIP4K2C, PLCG1, PIK3C2G, PIK3C2B, INPP5K, IMPA2, PIP5K1C, INPPL1, INPP5J, ISYNA1, PIK3CB, PTEN, PLCB3, IPMK",0.164943898279884,0.0150228735845067,FALSE
+"Coldren et al","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.32542,0.949,0.531,6911,0.897,"CBLC, PPP1R3D, HK2, PTPN1, PIK3R2, GYS1, CALML3, SOCS1, MKNK1, GCK, IKBKB, MAPK3, RPS6KB2, FBP1, INSR, PPP1CA, SH2B2, PIK3CA, PPP1CB, PRKCI, TSC1, FBP2, IRS2, PTPRF, CBLB, BRAF, PRKAA1, PHKG1, HK1, FOXO1, PRKCZ, BAD, PRKAG2, INPP5K, EXOC7, PIK3R3, FASN, PYGL, CALML6, CRKL, PRKAB2, PRKACA, RHEB, PPP1R3B, MAPK1, FLOT2, MAPK10, PIK3R5, IRS1, PIK3CB, PRKAR1B, GSK3B, PHKG2, TRIP10, GRB2, INPP5D, PYGB, PRKAG1, TSC2, RPTOR",0.274905478918531,0.0472075569559079,FALSE
+"Coldren et al","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.3125,0.916,0.603,3908,0.941,"TNFSF13, ICOSLG, LTBR, CCL28, CD40, PIGR, IL6",0.219682687859849,0.0264103765727431,FALSE
+"Coldren et al","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.33678,0.982,0.455,5894,0.859,"IFNL3, IFNL1, CBLC, STAT2, IFNL2, CRLF2, PIK3R2, IL9R, IRF9, JAK3, IL4R, SOCS1, CISH, IFNLR1, EPOR, PTPN6, IFNB1, PIK3CA, TYK2, EP300, STAT6, CTF1, STAT5B, IL12B, CBLB, STAT3, CLCF1, IL7R, EPO, IL20RB, IL6R, IL6, PIAS3, IL20RA, PIM1, CSF2, PIK3R3, SPRY1, IL15RA, STAT1, IL12A, PRLR, GH2, STAT5A, OSMR, IFNGR1, JAK1, CSF2RB, STAM2, PIK3R5, PIK3CB",0.341988603342888,0.0660068361687577,FALSE
+"Coldren et al","Log2FC","KEGG_LEISHMANIA_INFECTION",0.42556,1.24,0.175,6358,0.691,"TRAF6, ITGB2, NCF4, MAPK13, MAPK3, PTPN6, MYD88, IL12B, TAB1, RELA, MAPK11, C3, TLR2, IRAK4, STAT1, IL12A, TGFB3, IL1A, IFNGR1, JAK1, TAB2, MAPK1, NFKBIA, FOS, ITGA4",0.756961951313706,0.160521952625802,FALSE
+"Coldren et al","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.41873,1.21,0.176,3793,0.675,"CTNND1, CLDN8, ITGB2, MMP9, CLDN9, VAV1, NCF4, CLDN7, MAPK13, PIK3R2, PLCG2, CLDN4, F11R, CDH5, RAC2, VAV3, VAV2, CLDN18, PIK3CA, RASSF5, PTK2B, RAP1A, CLDN11, RAPGEF3, PLCG1, SIPA1, PXN, CLDN23, CLDN3, MYL9, MAPK11, ARHGAP35",0.75448733218585,0.170696227168975,FALSE
+"Coldren et al","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.42081,-1.51,0.0654,15341,0.301,"ALDH3A2, HADHA, YOD1, ALDH1B1, ALDH7A1, ALDH9A1",1.18442225167573,0.521433504406157,FALSE
+"Coldren et al","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.40266,1.15,0.249,2596,0.71,"PLA2G12A, CYP2E1, PLA2G6, PLA2G4B, CYP2J2, PLA2G10, PLA2G4E",0.603800652904264,0.148741651280925,FALSE
+"Coldren et al","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.24312,0.706,0.906,6599,0.989,"PLA2G12A, GNAO1, PLA2G6, PLA2G4B, MAPK3, IGF1R, RYR1, PLA2G10, PLA2G4E, BRAF, PLA2G2C, GNAS, GNAQ, LYN, ITPR3, MAPK1, PLCB3, PPP2R1A, GUCY1A1, NOS1, PLA2G2F, GUCY1B1, GNA12",0.0428718023231869,0.0048037084028206,FALSE
+"Coldren et al","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23447,0.686,0.938,5774,0.986,"GRIN1, CALML3, CAMK2G, MAPK3, PPP1CA, PPP1CB, EP300, RAP1A, RAPGEF3, GRIN2A, BRAF, GRIN2D, CHP1, PPP3CA, GNAQ, RPS6KA2, CALML6, ITPR3, PRKACA, MAPK1, RPS6KA1",0.0277971616209356,0.0061230850587888,FALSE
+"Coldren et al","Log2FC","KEGG_LYSINE_DEGRADATION",0.22598,0.645,0.958,2472,0.99,"BBOX1, KMT5B, KMT5C, GCDH, AASDH, EHHADH",0.0186344909214556,0.00436480540245009,FALSE
+"Coldren et al","Log2FC","KEGG_LYSOSOME",0.52683,1.52,0.0349,5277,0.466,"CTSH, GM2A, CTSA, CTSV, HGSNAT, SLC11A1, NAGLU, GGA2, CTSD, ARSA, ATP6V0D2, LIPA, DNASE2, ABCB9, SUMF1, GAA, MANBA, NPC1, NAGA, ACP5, PSAP, IDS, GNPTG, NPC2, AP1M2, GALNS, CTSS, LAPTM4A, NAPSA, AP1B1, AP3M2, GGA1, LGMN, NEU1, TPP1, ATP6AP1, PSAPL1, ASAH1, LAMP3, CD68, CTSB, LAMP1, CLN5, GUSB, GLB1, GGA3, AP3S2, LAMP2, FUCA1, NAGPA, SCARB2, CTSE, HEXB, PPT1, AP1S1, TCIRG1, MAN2B1, CD63, SLC11A2, MFSD8, ABCA2, CTSZ, SORT1, AP1S3, ATP6V0A4, ENTPD4, GBA",1.45717457304082,0.33161408331,FALSE
+"Coldren et al","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.26798,0.771,0.828,5856,1,"NTF4, PLA2G12A, TRAF6, FGF11, FGFR2, MAPK13, PDGFA, CACNA1D, RAC2, CACNG1, PLA2G6, PLA2G4B, MAP3K4, MKNK1, DUSP9, CACNB3, HSPB1, CACNG4, IKBKB, MAPK3, ARRB1, MAP4K1, MAP3K1, PDGFB, CACNA1I, FGF1, DUSP3, MAPK8IP2, MAX, NTRK2, PLA2G10, EGFR, CACNB2, PLA2G4E, MAP3K11, MAPKAPK3, RAP1A, JUND, ECSIT, MAP3K6, TAB1, LAMTOR3, FGFR3, MAP3K13, TAOK3, BRAF, DUSP10, RELA, STK3, DUSP14, CHP1, HSPA1B, MAPK11, PPP3CA, PAK2, PLA2G2C, MECOM, MAP3K8, GADD45B, RASGRF1, FGF12, MAP4K2, MAP3K5, RPS6KA2, IL1R2, RASA1, RPS6KA4, MAPKAPK2, NF1, STK4, TGFB3, CRKL, PPM1A, HSPA2, NGF, PRKACA, IL1A, RAC1, PAK1, MAP4K3, TGFBR2, RRAS, TAB2, MAPK1, DUSP8, MAP2K7, NLK, GADD45A, RPS6KA1, MAPK10, MAPK8IP3, CACNA1F",0.0819696632151199,0,FALSE
+"Coldren et al","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26478,0.762,0.824,1432,0.985,"HES1, GCK",0.0840727883028842,0.00656376950238827,FALSE
+"Coldren et al","Log2FC","KEGG_MELANOGENESIS",0.36219,1.04,0.393,6175,0.766,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, GNAO1, CALML3, WNT4, DVL3, CAMK2G, MAPK3, ADCY5, WNT10A, ADCY4, EP300, ADCY6, TCF7L1, FZD4, CREB3L4, DVL2, WNT11, GNAS, GNAQ, CALML6, CREB3L3, MITF, PRKACA, ASIP, CREB3L2, MAPK1, EDN1, CREB3L1, WNT5A, PLCB3, FZD6, GSK3B",0.405607449624573,0.115771230367396,FALSE
+"Coldren et al","Log2FC","KEGG_MELANOMA",-0.26432,-0.889,0.51,16564,0.929,"PIK3R1, PIK3CG, FGF20, CDK6, FGF21, FGF2, PDGFRA, E2F2, NRAS, IGF1, FGF9, FGF4, CDKN2A, FGF5, FGFR1, E2F3, FGF19, FGF3",0.292429823902064,0.0319842860063582,FALSE
+"Coldren et al","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.45636,1.33,0.0793,3662,0.805,"ADH7, ALDH3B2, GSTK1, DHDH, CYP2E1, CYP1B1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, MGST2, UGT2B17, MGST3",1.1007268126824,0.0942041196321315,FALSE
+"Coldren et al","Log2FC","KEGG_MISMATCH_REPAIR",-0.32549,-1.16,0.208,15319,0.53,"MSH6, RFC3, MSH3, RFC2, RFC5, EXO1, MSH2, RFC1, RPA2",0.681936665037238,0.275724130399211,FALSE
+"Coldren et al","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35512,1.02,0.409,6050,0.795,"PIK3R2, VEGFB, MAPK3, RPS6KB2, PIK3CA, TSC1, CAB39, RICTOR, BRAF, PRKAA1, PGF, VEGFA, PIK3R3, HIF1A, RPS6KA2, DDIT4, VEGFC, RHEB, MAPK1, RPS6KA1, PIK3R5, PIK3CB, ULK1",0.388276691992658,0.0996328713435297,FALSE
+"Coldren et al","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.2602,0.76,0.835,6624,0.98,"ITGB2, VAV1, PIK3R2, PLCG2, RAC2, VAV3, RAET1L, MAPK3, PTPN6, VAV2, IFNB1, PIK3CA, SH3BP2, PTK2B, TNFSF10, BRAF, PLCG1, CHP1, PPP3CA, LCK, CSF2, PIK3R3, ULBP2, RAC1, IFNGR1, PAK1, BID, MAPK1, NFATC1, PIK3R5, PIK3CB, SYK, NFATC4, HCST, GRB2, CHP2",0.0783135245163979,0.00877392430750515,FALSE
+"Coldren et al","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.21335,0.627,0.962,5100,0.987,"DRD5, P2RY2, VIPR2, PTAFR, BDKRB2, P2RY6, P2RX4, LPAR2, VIPR1, S1PR4, THRB, GRIN1, NPBWR1, ADORA1, ADORA2B, ADORA2A, GIPR, S1PR2, GALR3, CGA, BDKRB1, GHSR, GABRP, F2RL3, GRIN2A, OPRL1, CHRNB4, MLNR, S1PR5, ADRB2, GRIN2D, P2RX6, EDNRA, F2RL1, MC3R, P2RX2, LTB4R2, HTR7, CHRNB1, ADRA2A, GRIN3B, GRM4, LTB4R, PRLR, ADRA2B, GH2",0.0168249279621871,0.00568284733036327,FALSE
+"Coldren et al","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.33316,0.964,0.501,5975,0.882,"GAB1, NTF4, PRKCD, TRAF6, MAPK13, PIK3R2, PLCG2, FOXO3, CALML3, ARHGDIB, IKBKB, CAMK2G, MAPK3, MAP3K1, SH2B2, PIK3CA, NTRK2, RAP1A, IRS2, TP73, BRAF, PLCG1, YWHAB, RELA, MAPK11, NGFR, IRAK4, BAD, YWHAZ, MAP3K5, PIK3R3, YWHAH, RPS6KA2, SORT1, CALML6, RPS6KA4, MAPKAPK2, CRKL, NGF, RAC1, BAX, MAPK1, MAP2K7, RPS6KA1, MAPK10, PIK3R5, IRS1, PIK3CB, NFKBIA",0.300162274132754,0.0545314148681803,FALSE
+"Coldren et al","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.264,0.764,0.85,4274,0.997,"QPRT, NMRK1, NADSYN1, NADK, NT5C1B",0.0705810742857073,0.00130484168834428,FALSE
+"Coldren et al","Log2FC","KEGG_NITROGEN_METABOLISM",0.31831,0.916,0.617,2116,0.941,"GLUL, HAL, GLS2, CA9",0.209714835966758,0.0264103765727431,FALSE
+"Coldren et al","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34339,1,0.462,4477,0.835,"CASP1, TRAF6, MAPK13, TAB3, IKBKB, MAPK3, TRIP6, CCL5, IL18, PYCARD, TAB1, RELA, CARD6, MAPK11, IL6, NOD1, NOD2, PSTPIP1, NLRP1",0.335358024443874,0.0783135245163979,FALSE
+"Coldren et al","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.55072,-1.94,0.01,17605,0.437,"RAD50, PRKDC, NHEJ1, XRCC5",2,0.359518563029578,FALSE
+"Coldren et al","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.34338,0.984,0.482,3686,0.863,"ERBB2, RXRA, PIK3R2, PLCG2, FOXO3, MAPK3, PIK3CA, RASSF5, RXRB, EGFR, E2F1, BRAF, PLCG1, TGFA",0.31695296176115,0.0639892042847904,FALSE
+"Coldren et al","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.39588,1.13,0.278,5482,0.707,"DTX4, HES1, DVL3, DTX3L, JAG1, DTX2, RFNG, EP300, DLL1, LFNG, NOTCH3, APH1A, MFNG, DVL2, JAG2, NUMB, NOTCH1, KAT2A, HES5",0.555955204081924,0.150580586203101,FALSE
+"Coldren et al","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.30853,-1.02,0.344,15978,0.705,"RFC2, XPC, RFC5, GTF2H1, XPA, GTF2H3, ERCC3, CUL4A, ERCC8, CCNH, ERCC1, POLE3, RFC1, RPA2, GTF2H2",0.46344155742847,0.151810883008601,FALSE
+"Coldren et al","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39086,1.12,0.267,3600,0.712,"MAN1B1, RPN2, ALG12, ALG3, DPM1, MOGS, MGAT4A, MGAT1, B4GALT1, MGAT5B, STT3A, ALG2, B4GALT2",0.573488738635425,0.147520006363144,FALSE
+"Coldren et al","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.24959,0.715,0.895,7709,1,"OR4C6, OR10H2, OR2J3, OR11H4, OR8A1, OR2A12, OR2D3, GUCY2D, CALML3, OR8B8, CAMK2G, CLCA2, OR1G1, OR2A7, OR13H1, OR1I1, OR13D1, CNGB1, OR1F1, OR8G5, OR8G1, OR10A3, OR1M1, OR6Q1, OR1K1, OR5P2, OR10H1, OR10A4, OR4D2, OR2A2, CNGA4, OR52B4, CALML6, OR2D2, OR2B2, OR1J1, OR6B1, PRKACA, OR2A14, GUCA1B, OR52K1, OR9A2, OR10A6, OR4L1, OR10AD1, OR2S2, OR10S1, OR10A2, OR2A5, OR10K2, OR10A5, OR8S1, OR4X2, OR5P3, ADCY3, OR6C70, OR8D2, OR8B4, OR2L2, CAMK2D, OR10G3, PRKG2, OR4K1, PRKACG, GRK3, OR8D1, OR52I1, OR6A2",0.048176964684088,0,FALSE
+"Coldren et al","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44426,-1.59,0.0263,14974,0.298,"DHFR, SHMT2, MTHFS, MTR, MTHFD2L, GART, MTHFD2, MTHFD1L, TYMS, ATIC",1.58004425151024,0.525783735923745,FALSE
+"Coldren et al","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.25168,-0.884,0.57,15742,0.907,"ITPR2, PPP2R5D, PPP3CC, ADCY7, PPP2R5C, PRKX, RPS6KA3, PTTG2, PPP2CB, PPP2R1B, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, ITPR1, ANAPC10, FBXO5, CDC20, PRKACB, PPP3R1, CDK1, SMC1A, CALM2, CCNB1, FBXO43, CPEB1, AR, PTTG1, YWHAQ, SGO1, SMC3, IGF1, PPP1CC, ANAPC13",0.244125144327509,0.0423927129399047,FALSE
+"Coldren et al","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",0.61199,1.77,0.0123,5940,0.351,"MANBA, NEU1, ENGASE, MAN2B2, MAN2C1, GLB1, FUCA1, HEXB, MAN2B1, GBA, HEXA, AGA",1.9100948885606,0.454692883534176,FALSE
+"Coldren et al","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",0.23049,0.67,0.923,6376,0.986,"NDUFV1, LHPP, ATP6V1C2, COX5B, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP5F1E, NDUFB7, NDUFS8, NDUFA3, NDUFV2, ATP6AP1, COX6C, UQCR10, COX6B2, SDHD, UQCR11, TCIRG1, NDUFB4, NDUFAB1, ATP6V1G1, UQCRB, ATP6V0A4, NDUFA6, UQCRHL, NDUFA5, UQCRC1, NDUFB5, COX15, ATP5MG, UQCRFS1, ATP6V1C1, UQCRC2, COX6A1, ATP6V1E1, NDUFA2, COX17, ATP5PD",0.0347982989740879,0.0061230850587888,FALSE
+"Coldren et al","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.49419,1.43,0.0514,4056,0.61,"GALNT12, GALNT3, GALNT7, GALNT6, B4GALT5, GCNT1, ST6GALNAC1, GCNT3, C1GALT1, GALNT15, ST3GAL1, GALNT11, GALNT9, B3GNT6",1.28903688100472,0.214670164989233,FALSE
+"Coldren et al","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.1914,0.551,0.988,5981,0.999,"TP53AIP1, CCNG2, CD82, SERPINB5, SFN, THBS1, TP73, ATR, PERP, SHISA5, EI24, GADD45B, ZMAT3, CCNE1, SIAH1, PIDD1, BID, IGFBP3, BAX, CHEK2, GADD45A, PTEN",0.00524305541237188,0.000434511774017692,FALSE
+"Coldren et al","Log2FC","KEGG_PANCREATIC_CANCER",0.34675,0.996,0.452,5894,0.837,"ERBB2, PLD1, PIK3R2, RALB, RAC2, VEGFB, IKBKB, MAPK3, RALGDS, PIK3CA, EGFR, E2F1, RALBP1, STAT3, BRAF, RELA, TGFA, BAD, PGF, VEGFA, PIK3R3, STAT1, TGFB3, RALA, VEGFC, RAC1, JAK1, TGFBR2, MAPK1, MAPK10, PIK3R5, PIK3CB",0.344861565188618,0.07727454200674,FALSE
+"Coldren et al","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.31788,0.93,0.561,8542,0.943,"PANK2, PPCS, ENPP1, COASY, UPB1, PPCDC, BCAT2, DPYD, VNN2",0.251037138743839,0.0254883072626717,FALSE
+"Coldren et al","Log2FC","KEGG_PARKINSONS_DISEASE",-0.18037,-0.639,0.966,17631,1,"UBE2J2, ATP5F1C, NDUFA9, VDAC2, LRRK2, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, UCHL1, ATP5F1A, SLC18A2, PARK7, NDUFS5",0.0150228735845067,0,FALSE
+"Coldren et al","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.30571,-1.05,0.38,18248,0.704,"YWHAQ, TUBA1A, NCL, ROCK2, TUBB4A, ARHGEF2, TUBB2B, TUBB2A",0.42021640338319,0.152427340857888,FALSE
+"Coldren et al","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.2849,0.834,0.737,5981,1,"WNT3A, WNT9A, CBLC, CSF1R, WNT7B, CDH1, ERBB2, FZD10, LAMA3, TRAF6, FGF11, MMP9, RXRA, BCR, FGFR2, TRAF4, PLD1, PDGFA, PIK3R2, PLCG2, RALB, LAMB3, EGLN3, WNT7A, RAC2, WNT4, VEGFB, LAMC2, DVL3, IKBKB, MAPK3, RALGDS, PML, PDGFB, RARA, BMP2, FLT3LG, PIK3CA, JUP, RASSF5, WNT10A, FADD, RXRB, MET, IGF1R, FGF1, MAX, ITGA3, EP300, EGFR, GLI3, STAT5B, E2F1, DAPK1, RALBP1, FGFR3, ITGA2B, PPARG, CBLB, ARNT2, STAT3, BRAF, PLCG1, CDKN1B, RELA, TCF7L1, FZD4, TGFA, FOXO1, IL6, DVL2, MECOM, LAMA5, WNT11, RUNX1, BAD, PGF, PIAS3, LAMB1, EPAS1, ITGA2, VEGFA, FGF12, DAPK2, PIK3R3, HIF1A, STAT1, CCNA1, CCNE1, STK4, TGFB3, CRKL, PTCH1, RALA, MITF, SLC2A1, STAT5A, VEGFC, RAC1, JAK1, BID, TGFBR2, BAX, MAPK1, WNT5A, MAPK10, PIK3R5, TFG, PIK3CB, CEBPA, NFKBIA, PTEN",0.132532512140949,0,FALSE
+"Coldren et al","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.47895,1.37,0.0867,4741,0.734,"DHDH, UGT2B17, GUSB, RPEL1, DCXR",1.06198090252379,0.134303940083929,FALSE
+"Coldren et al","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.43515,1.26,0.141,5085,0.763,"PGLS, ALDOC, FBP1, PGM1, PFKL, FBP2, ALDOA, H6PD, G6PD, RPEL1, RBKS, DERA, PGM2",0.85078088734462,0.11747546204512,FALSE
+"Coldren et al","Log2FC","KEGG_PEROXISOME",0.42548,1.23,0.18,5270,0.704,"CAT, ACOT8, GSTK1, PRDX5, PEX11A, XDH, PXMP4, ACAA1, MVK, AGXT, PEX11G, PEX2, HMGCL, EPHX2, PAOX, IDH2, ACSL1, EHHADH, PEX11B, CROT, ABCD1, ACOX1, ACSL3, PEX10, PEX13, PEX26, SCP2, PEX7, MLYCD, SLC25A17, ABCD4, PEX1, ACSL5, ACSL6",0.744727494896694,0.152427340857888,FALSE
+"Coldren et al","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.40531,1.17,0.212,5148,0.738,"ALDH3B2, ALDH1A3, ALDH3B1, AOC2, NAA80, IL4I1, TAT, MAOA, MIF",0.673664139071249,0.131943638176958,FALSE
+"Coldren et al","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.30436,0.891,0.643,6064,0.959,"CDS1, DGKA, PIK3R2, PLCG2, INPP4B, PLCD1, CALML3, INPP4A, PIK3CA, PIP4K2C, CDS2, PLCG1, PIK3C2G, PIK3C2B, DGKH, INPP5K, IMPA2, PIK3R3, PIP5K1C, CALML6, DGKI, ITPR3, INPPL1, INPP5J, PIK3R5, PIK3CB, DGKE, PTEN, PLCB3",0.191789027075778,0.0181813928293364,FALSE
+"Coldren et al","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.31034,0.894,0.627,4098,0.961,"ALAD, CP, HMOX2, FTH1, UGT2B17, MMAB, GUSB, HMBS",0.202732459169284,0.0172766123314547,FALSE
+"Coldren et al","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.41424,1.21,0.178,5270,0.675,"RXRA, ACAA1, CPT1B, PPARA, PLIN1, CYP4A22, FABP6, ACSL1, RXRB, CPT2, CPT1C, EHHADH, SLC27A6, PLTP, SLC27A1, PPARG, ACOX1, ACSL3, SCD5, SLC27A4, SCP2, OLR1, ACSL5, ACSL6",0.749579997691106,0.170696227168975,FALSE
+"Coldren et al","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.20209,-0.707,0.941,14148,1,"ACOX2, HSD17B4, CYP7A1, HSD3B7, AKR1C4, CYP39A1, BAAT",0.0264103765727431,0,FALSE
+"Coldren et al","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.5701,1.65,0.0112,4719,0.336,"RFXANK, BLNK, RAG1, JAK3, CD40, ADA, CD79A, RAG2, CD19, IL7R, CIITA, LCK, CD4",1.95078197732982,0.473660722610156,FALSE
+"Coldren et al","Log2FC","KEGG_PRION_DISEASES",0.24524,0.708,0.915,5622,0.994,"MAPK3, CCL5, IL6, NOTCH1, PRKACA, IL1A, C9, BAX, MAPK1, EGR1",0.0385789059335517,0.00261361560268669,FALSE
+"Coldren et al","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28022,-0.975,0.418,15860,0.788,"ADCY7, PRKX, RPS6KA3, CCNA2, AKT3, MAD2L2, BUB1, CDC25C, CDC23, PIK3R1, GNAI1, PIK3CG, CCNB2, ANAPC10, PRKACB, CDK1, CCNB3, CDC25A, CCNB1, MAPK8, CPEB1, IGF1, HSP90AB1, HSP90AA1, ANAPC13, PDE3A, PDE3B",0.378823718224965,0.103473782510445,FALSE
+"Coldren et al","Log2FC","KEGG_PROPANOATE_METABOLISM",0.35657,1.04,0.389,3581,0.766,"LDHC, ACSS2, ALDH6A1, ABAT, MCEE, EHHADH, PCCB, ACSS1",0.410050398674292,0.115771230367396,FALSE
+"Coldren et al","Log2FC","KEGG_PROSTATE_CANCER",0.26783,0.77,0.841,6422,1,"ERBB2, FGFR2, PDGFA, PIK3R2, IKBKB, MAPK3, PDGFB, PIK3CA, IGF1R, PDGFD, EP300, EGFR, E2F1, BRAF, CDKN1B, RELA, TCF7L1, CREB3L4, TGFA, FOXO1, BAD, PIK3R3, CCNE1, CREB3L3, CREB3L2, MAPK1, CREB5, CREB3L1, PIK3R5, PIK3CB, NFKBIA, PTEN, GSK3B, CDKN1A, CREB3",0.0752040042020878,0,FALSE
+"Coldren et al","Log2FC","KEGG_PROTEASOME",-0.31612,-1.17,0.226,15132,0.543,"PSMB5, PSMD4, PSMD6, PSMC5, PSMB4, PSMA6, PSMD7, PSMC1, PSMC6, PSMD1, PSMC4, PSMB7, PSMA4, PSMA1, PSMD8, PSMB1, POMP, PSMD14",0.645891560852599,0.265200170411153,FALSE
+"Coldren et al","Log2FC","KEGG_PROTEIN_EXPORT",-0.31244,-1.07,0.309,16054,0.69,"SEC61A2, SEC11A, SRPRB, SRP72, SRP9, SRP19, SEC11C, SEC63",0.510041520575165,0.161150909262745,FALSE
+"Coldren et al","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.19349,0.56,0.993,8289,1,"GLS2, SLC9A3, SLC25A10, MDH1, SLC4A4, GLUD1, ATP1A2, AQP1, ATP1A1",0.00305075150461883,0,FALSE
+"Coldren et al","Log2FC","KEGG_PURINE_METABOLISM",-0.30249,-1.04,0.368,15717,0.692,"PNPT1, PRPS1, RRM2, ADCY7, PFAS, POLR3B, ENTPD8, POLR2L, RRM2B, PAICS, ADSL, APRT, GART, NPR2, RRM1, PDE6B, PNP, PRIM1, NME1, PDE6C, POLR3G, PDE8A, POLR3A, AK5, NME7, PPAT, PDE11A, PRIM2, POLE3, POLR2E, POLR3C, PDE1A, ATIC, ENTPD1, PDE4B, PDE4D, POLR2D, POLR1E, PDE3A, PDE3B, POLA1, PDE10A, PDE7B, PDE8B",0.434152181326482,0.159893905543242,FALSE
+"Coldren et al","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.25943,-0.912,0.557,14988,0.897,"DHODH, POLE, NT5E, NME2, UPP2, CAD, POLR2C, POLR3K, PNPT1, RRM2, POLR3B, ENTPD8, POLR2L, RRM2B, AK3, TXNRD1, DTYMK, RRM1, PNP, PRIM1, NME1, TYMS, POLR3G, POLR3A, NME7, PRIM2, POLE3, POLR2E, POLR3C, ENTPD1, POLR2D, POLR1E, UCK2, POLA1, CTPS1",0.254144804826271,0.0472075569559079,FALSE
+"Coldren et al","Log2FC","KEGG_PYRUVATE_METABOLISM",0.22031,0.64,0.956,1378,0.986,"LDHC, ACSS2, PC",0.0195421077238999,0.0061230850587888,FALSE
+"Coldren et al","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.28027,0.812,0.779,5612,1,"PAK6, SSH3, BDKRB2, MYH14, BAIAP2, FGF11, ITGB2, VAV1, FGFR2, ITGB6, PDGFA, PIK3R2, ITGB8, RAC2, VAV3, LIMK2, FGD3, ITGB4, ARHGEF4, MAPK3, PPP1CA, VAV2, GSN, PDGFB, PFN4, PIK3CA, PPP1CB, PIP4K2C, BDKRB1, FGF1, SSH2, PDGFD, ITGA3, EGFR, FGFR3, ITGA2B, BRAF, TIAM1, PXN, MYL9, TIAM2, ARHGAP35, PAK2, SLC9A1, ITGA2, WASL, FGF12, PIK3R3, PIP5K1C, LIMK1, CRKL, ARHGEF7, SCIN, MYL7, RAC1, IQGAP1, PAK1, RRAS, BCAR1, ITGAX, PAK4, MAPK1",0.108462542327436,0,FALSE
+"Coldren et al","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.20206,-0.716,0.901,18035,1,"PIK3C3, PRKAA2, IFNA13",0.045275209020937,0,FALSE
+"Coldren et al","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3643,1.07,0.323,5894,0.748,"GAB1, PAK6, PIK3R2, EGLN3, VEGFB, MAPK3, PDGFB, PIK3CA, MET, EP300, RAP1A, ARNT2, BRAF, TGFA, PAK2, PGF, EPAS1, VEGFA, PIK3R3, HIF1A, TGFB3, CRKL, FLCN, SLC2A1, VEGFC, RAC1, PAK1, PAK4, MAPK1, PIK3R5, PIK3CB",0.490797477668897,0.126098402135539,FALSE
+"Coldren et al","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.39819,1.15,0.231,4025,0.71,"CTSA, ACE2, ACE, ANPEP",0.636388020107856,0.148741651280925,FALSE
+"Coldren et al","Log2FC","KEGG_RETINOL_METABOLISM",0.43832,1.28,0.133,5807,0.746,"ADH7, RDH16, CYP26B1, DHRS9, DHRS3, DGAT1, CYP4A22, CYP26A1, UGT2B17, CYP1A1, RDH10, RDH11, LRAT, CYP26C1, CYP2C9, CYP2A7, ALDH1A2, AWAT2, CYP2C8",0.876148359032914,0.127261172527331,FALSE
+"Coldren et al","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.28656,0.826,0.712,3165,1,"ACP6, ACP5, MTMR1",0.147520006363144,0,FALSE
+"Coldren et al","Log2FC","KEGG_RIBOSOME",-0.37924,-1.29,0.19,14672,0.511,"RPL22L1, RPS23, RPL26, RPL21, RPL13A, RPS24, RPL10A, RPL37A, RPS11, RPS27A, RPL35, RPL10, RPL26L1, RPL34, RPL27A, RPLP0, RPL11, RPL32, RPS8, RPL18, RPS27, RPL9, RPS20, RPS10, RPS6, RPL4, RPL5, RPL14, RPSA, RPS13, RPS7, RPS19, RSL24D1, RPS12, RPL6, RPS4Y1, RPS16, RPL17",0.721246399047171,0.291579099865287,FALSE
+"Coldren et al","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.42041,1.22,0.156,3761,0.678,"TRADD, TRAF6, DHX58, MAPK13, MAVS, IRF3, CXCL10, IKBKB, IFNB1, MAP3K1, TKFC, FADD, ISG15, IFIH1, DDX58, NLRX1, IL12B, CASP10, RELA, MAPK11, IKBKE",0.806875401645538,0.168770306132937,FALSE
+"Coldren et al","Log2FC","KEGG_RNA_DEGRADATION",-0.39068,-1.33,0.115,15014,0.479,"CNOT7, LSM2, EXOSC6, LSM1, LSM5, CNOT1, PNPT1, DCP1A, LSM7, EDC4, LSM3, EXOSC9, CNOT10, EXOSC5, EXOSC3, PAPOLA, TTC37, ZCCHC7, EXOSC10, MTREX, ENO1, DCP2, CNOT9, ENO3, EXOSC8, HSPA9, DCP1B, HSPD1",0.939302159646388,0.319664486585437,FALSE
+"Coldren et al","Log2FC","KEGG_RNA_POLYMERASE",-0.36582,-1.24,0.233,17492,0.48,"POLR3G, POLR3A, POLR2E, POLR3C, POLR2D, POLR1E",0.632644078973981,0.318758762624413,FALSE
+"Coldren et al","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.20795,-0.68,0.943,17399,1,"SCLY, MAT2A, MARS2, SEPHS1, TRMT11",0.0254883072626717,0,FALSE
+"Coldren et al","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.2741,0.799,0.815,4622,0.995,"LAMA3, TRAF6, RXRA, TRAF4, PIK3R2, LAMB3, LAMC2, IKBKB, PIK3CA, RXRB, MAX, ITGA3, E2F1, ITGA2B, CDKN1B, RELA, LAMA5, PIAS3, LAMB1, ITGA2, PIK3R3",0.0888423912600234,0.00217691925427455,FALSE
+"Coldren et al","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.44073,1.28,0.138,4358,0.746,"SNAP23, STX16, STX10, VAMP8, STX19, YKT6, STX17, VTI1B, TSNARE1, STX3, GOSR2, SNAP29, BET1, USE1, STX5, BET1L",0.860120913598763,0.127261172527331,FALSE
+"Coldren et al","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.24714,0.726,0.897,8272,1,"ARSA, SPTLC2, NEU1, ASAH1, PLPP3, DEGS2, SPHK2, GLB1, SPHK1, GBA, SGMS2, SGPP1, SPTLC1, ENPP7, UGCG, SMPD3, SMPD2, SGPP2, NEU2, SMPD1, UGT8",0.0472075569559079,0,FALSE
+"Coldren et al","Log2FC","KEGG_SPLICEOSOME",-0.28279,-0.974,0.491,14820,0.756,"HSPA1A, SNRNP27, DDX23, LSM2, SF3A3, SF3B1, SNRPB, SNRPF, PRPF8, BCAS2, LSM5, PRPF3, THOC1, SRSF3, SF3A2, DDX39B, EIF4A3, LSM7, SF3B4, TCERG1, RBM22, U2AF1, LSM3, SNRNP40, SYF2, DDX5, HNRNPK, DHX15, HNRNPA1L2, BUD31, PQBP1, PRPF40A, THOC2, PRPF4, SNRPA1, RBM8A, ALYREF, CDC5L, RBM17, SRSF7, SNRPE, PRPF18, SNRPD2, CDC40, SNRPC, RBMX, SRSF1, HNRNPA3, HSPA8, HNRNPM, HNRNPA1, HNRNPC, SF3B5, MAGOHB, PPIH, HNRNPU, PPIE, TXNL4A, SRSF10",0.308918507877032,0.121478204498793,FALSE
+"Coldren et al","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44369,1.29,0.117,7075,0.806,"HK2, GYS1, GCK, GAA, PGM1, GANC, UGT2B17, GUSB, HK1, UXS1, PYGL, PGM2, ENPP1, MGAM, PYGB, AMY1A, UGP2, AGL",0.931814138253838,0.0936649581949093,FALSE
+"Coldren et al","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.61834,1.81,0.00447,5003,0.376,"MSMO1, DHCR24, LIPA, SC5D, SQLE, FDFT1, HSD17B7, CEL, NSDHL, DHCR7, LSS, TM7SF2",2.34969247686806,0.424812155072339,FALSE
+"Coldren et al","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38862,1.13,0.265,4669,0.707,"CYP11B1, CYP1B1, SULT2B1, SRD5A1, COMT, SRD5A3, CYP7B1, UGT2B17, HSD17B7, SULT1E1, CYP1A1, HSD17B8",0.576754126063192,0.150580586203101,FALSE
+"Coldren et al","Log2FC","KEGG_SULFUR_METABOLISM",0.55174,1.58,0.0274,5093,0.399,"SULT2B1, CHST12, SULT1A2, SUOX, SULT1A4, CHST11, SULT1E1, SULT1A3",1.56224943717961,0.399027104313252,FALSE
+"Coldren et al","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.21402,-0.75,0.783,18576,1,"SSB, GRIN2B",0.106238237942057,0,FALSE
+"Coldren et al","Log2FC","KEGG_TASTE_TRANSDUCTION",0.22218,0.65,0.948,6205,0.993,"KCNB1, SCNN1A, ADCY4, TAS2R1, SCNN1G, TAS1R3, ADCY6, GNAS, TAS2R3, GRM4, TAS2R31, SCNN1B, ITPR3, PRKACA, TAS2R4, TAS2R38, TAS2R5",0.0231916626619338,0.00305075150461883,FALSE
+"Coldren et al","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.24456,0.721,0.896,3450,1,"GGT7, GGT6",0.0476919903378748,0,FALSE
+"Coldren et al","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.41775,1.22,0.158,5412,0.678,"MVK, HMGCS1, MVD, DHDDS, HMGCR",0.801342913045577,0.168770306132937,FALSE
+"Coldren et al","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21463,-0.731,0.826,15652,1,"SMAD7, TFDP1, RHOA, BMPR2, SMAD5, PITX2, BMP8B, PPP2CB, PPP2R1B, ID3, SMAD4, SKP1, SMURF2, BMPR1A, INHBE, SMAD9, BMP8A, ID2, TGFB1, CDKN2B, E2F5, ROCK2, BMP6, SMAD2",0.0830199526796178,0,FALSE
+"Coldren et al","Log2FC","KEGG_THYROID_CANCER",0.39121,1.13,0.275,3392,0.707,"CDH1, RXRA, MAPK3, RXRB, PPARG, BRAF, TCF7L1",0.560667306169737,0.150580586203101,FALSE
+"Coldren et al","Log2FC","KEGG_TIGHT_JUNCTION",0.33254,0.963,0.523,4350,0.875,"EPB41L1, PRKCD, AMOTL1, MYH14, CLDN8, CGN, CLDN9, CLDN7, CLDN4, F11R, TJP3, CRB3, TJP2, PRKCH, LLGL2, CLDN18, PRKCI, PARD6B, PATJ, CLDN11, CTTN, EXOC4, CLDN23, CLDN3, SRC, MYH15, MYL9, EXOC3, MAGI1, PRKCZ, OCLN",0.281498311132726,0.0579919469776868,FALSE
+"Coldren et al","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43206,1.27,0.12,6260,0.755,"TLR5, TRAF6, MAPK13, PIK3R2, IRF5, LBP, IRF3, TOLLIP, CXCL10, IKBKB, MAPK3, TLR3, IFNB1, PIK3CA, MYD88, FADD, CXCL11, CCL5, CD40, IL12B, CXCL9, TAB1, RELA, TLR1, MAPK11, IKBKE, IL6, TLR2, MAP3K8, IRAK4, TIRAP, TICAM1, PIK3R3, STAT1, IL12A, RAC1, TAB2, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB, NFKBIA, FOS, IRF7",0.920818753952375,0.122053048370812,FALSE
+"Coldren et al","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.25994,0.746,0.859,5698,0.992,"CAT, CYP1B1, GCDH, KMO, EHHADH, IL4I1, CYP1A1, MAOA, IDO1, HAAO, OGDHL",0.0660068361687577,0.00348832784582135,FALSE
+"Coldren et al","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.35999,1.05,0.348,1965,0.767,"PRKCD, HK2, PIK3R2, CACNA1D, SOCS1, GCK, IKBKB, MAPK3, INSR, PIK3CA",0.458420756053419,0.115204636051019,FALSE
+"Coldren et al","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",-0.22684,-0.827,0.773,16990,1,"PRF1, PTPRN, HSPD1",0.111820506081675,0,FALSE
+"Coldren et al","Log2FC","KEGG_TYROSINE_METABOLISM",0.48583,1.41,0.0615,2773,0.632,"ADH7, ALDH3B2, HEMK1, TH, ALDH1A3, ALDH3B1, COMT, AOC2, GSTZ1, NAA80, LCMT1",1.21112488422458,0.199282921717615,FALSE
+"Coldren et al","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29483,0.851,0.699,6624,0.99,"PAK6, CBLC, VAV1, MAPK13, PIK3R2, VAV3, DLG1, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, NCK2, CBLB, PLCG1, RELA, CHP1, MAPK11, PPP3CA, PAK2, LCK, MAP3K8, CSF2, PIK3R3, CD4, NCK1, PAK1, PAK4, MAPK1, MAP2K7, NFATC1, PIK3R5, PIK3CB, NFKBIA, GSK3B, FOS, NFATC4, GRB2, CHP2",0.155522824254319,0.00436480540245009,FALSE
+"Coldren et al","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29203,0.849,0.695,6099,0.986,"CBLC, UBOX5, ITCH, UBA7, TRAF6, UBE2H, PPIL2, SOCS1, FBXO2, SMURF1, PML, MAP3K1, FBXW7, UBE2L6, RHOBTB2, HERC1, HERC3, ANAPC2, CUL7, UBE2D4, CBLB, FBXO4, RNF7, MID1, SYVN1, UBA6, FBXW8, UBR5, UBE2C, PIAS3, KLHL13, UBE3B, UBE2W, HUWE1, NEDD4L, UBE2F, TRIM32, UBE2Q1, WWP2, DDB1, SIAH1, FZR1, UBE4A, UBE2E1, UBE3C, DET1, UBE2O, UBE2E2, STUB1, UBA3, ANAPC11, UBE2M, UBE2Z",0.158015195409886,0.0061230850587888,FALSE
+"Coldren et al","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.54815,-1.85,0.0204,13596,0.202,"VARS2, LARS2, BCAT1, PDHA1, IARS2",1.6903698325741,0.694648630553376,TRUE
+"Coldren et al","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.42231,1.25,0.157,3822,0.723,"MCCC1, ACAA1, HIBADH, ACAD8, ALDH6A1, ABAT, HMGCL, HMGCS1, MCEE, ACADS, EHHADH, PCCB, IL4I1, AUH",0.804100347590766,0.140861702705469,FALSE
+"Coldren et al","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28813,0.834,0.724,4348,1,"PRKCD, PLA2G12A, KCNMB3, CACNA1D, PLA2G6, CALML3, PLA2G4B, ADORA2B, MAPK3, ADORA2A, PPP1CA, PRKCH, ADCY5, CYP4A22, PPP1CB, ADCY4, PLA2G10, PLA2G4E, BRAF, ADCY6, MYL9, PLA2G2C, EDNRA, KCNMB4, GNAS, GNAQ",0.140261433802853,0,FALSE
+"Coldren et al","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.27394,0.8,0.79,7785,1,"DYNLL2, AQP3, RAB5B, ARHGDIB, ADCY6, CREB3L4, GNAS, DYNC2LI1, DCTN5, CREB3L3, PRKACA, CREB3L2, RAB11B, RAB5C, CREB5, CREB3L1, CREB3, ADCY9, ADCY3, NSF, CREB1, RAB11A, PRKACG, DCTN1",0.102372908709559,0,FALSE
+"Coldren et al","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.37587,1.1,0.288,5894,0.725,"PLA2G12A, MAPK13, PIK3R2, PLCG2, RAC2, PLA2G6, PLA2G4B, NOS3, HSPB1, MAPK3, PIK3CA, PLA2G10, PLA2G4E, MAPKAPK3, PLCG1, SPHK2, PXN, SRC, CHP1, MAPK11, PPP3CA, PLA2G2C, BAD, VEGFA, PIK3R3, SPHK1, MAPKAPK2, RAC1, MAPK1, NFATC1, PIK3R5, PIK3CB",0.540607512240769,0.139661993429006,FALSE
+"Coldren et al","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.35881,1.04,0.371,7679,0.766,"ERO1A, PLCG2, ATP6V1C2, TJP2, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP6AP1, KDELR3, PLCG1, PDIA4, GNAS, TCIRG1, KCNQ1, ATP6V1G1, SEC61G, ATP6V0A4, PRKACA, KDELR2, ATP6V1C1, TJP1, ATP6V1E1, ADCY9, ADCY3, SEC61B, ATP6V0C, PRKACG, ATP6V1E2, ATP6V0E2",0.430626090384954,0.115771230367396,FALSE
+"Coldren et al","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.26233,0.766,0.839,3633,1,"MYH14, ITGB2, RAC2, DAG1, CD40, EIF4G1, CAV1, MYH15",0.0762380391712997,0,FALSE
+"Coldren et al","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.25146,0.728,0.866,2541,1,"WNT3A, WNT9A, TBL1XR1, WNT7B, DAAM1, FZD10, PORCN, WNT7A, RAC2, SENP2, WNT4, FRAT1, CTNNBIP1, DVL3, CAMK2G, FRAT2, CSNK1E, WNT10A, LRP5, CSNK1A1, EP300, VANGL2",0.0624821079826534,0,FALSE
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diff --git a/Examples/Fig3/DMEA/DMEA_interactive_network.graph.html b/Examples/Fig3/DMEA/DMEA_interactive_network.graph.html
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+++ b/Examples/Fig3/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-187199a327716f9b61e6" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/Fig3/DMEA/DMEA_mean_results.csv b/Examples/Fig3/DMEA/DMEA_mean_results.csv
new file mode 100644
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+"MDM inhibitor",1.86666666666667,0.265015722804013,0.000475898353953111,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, metabolomics",0.012849255556734
+"HMGCR inhibitor",1.82,0.252388589282479,1.52209119223203e-05,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.00123289386570794
+"PLK inhibitor",1.62666666666667,0.239652526240249,0.000410344949248524,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.012849255556734
+"microtubule inhibitor",1.54666666666667,0.245424801789333,0.00334884736346567,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.0678141591101799
+"Aurora kinase inhibitor",1.45333333333333,0.089628864398325,0.0135858996870902,"transcriptomics, proteomics, metabolomics",3,0,"",0.176684580818349
+"tubulin polymerization inhibitor",1.43333333333333,0.243378991150291,0.0174503289697135,"transcriptomics, proteomics, metabolomics",3,0,"",0.176684580818349
+"sterol demethylase inhibitor",1.35333333333333,0.0665832811847939,0.0586291436870008,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444
+"acetylcholine receptor agonist",1.31333333333333,0.0776745346515402,0.0817710395821918,"transcriptomics, proteomics, metabolomics",3,0,"",0.287976269832936
+"protein synthesis inhibitor",1.31333333333333,0.150111069989303,0.0760879765060129,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444
+"PARP inhibitor",1.29666666666667,0.181475434517549,0.0671557019171678,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444
+"RAF inhibitor",1.28733333333333,0.518711223450325,0.0172805979005271,"transcriptomics, proteomics, metabolomics",3,0,"",0.176684580818349
+"DNA polymerase inhibitor",1.20666666666667,0.198578280114753,0.15892160326282,"transcriptomics, proteomics, metabolomics",3,0,"",0.433447304602584
+"serotonin receptor agonist",1.203,0.341214009091069,0.135379131943202,"transcriptomics, proteomics, metabolomics",3,0,"",0.421758064899977
+"topoisomerase inhibitor",1.178,0.532326967192157,0.0775610159577255,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444
+"ATPase inhibitor",1.17666666666667,0.228108161479008,0.21362467604965,"transcriptomics, proteomics, metabolomics",3,0,"",0.500845418127828
+"DNA synthesis inhibitor",1.17033333333333,0.295398600764007,0.182965639853951,"transcriptomics, proteomics, metabolomics",3,0,"",0.463131775880312
+"growth factor receptor inhibitor",1.16666666666667,0.240069434400411,0.210093890642291,"transcriptomics, proteomics, metabolomics",3,0,"",0.500845418127828
+"AP inhibitor",1.13266666666667,0.190161335011441,0.308401804743253,"transcriptomics, proteomics, metabolomics",3,0,"",0.624513654605088
+"androgen receptor antagonist",1.084,0.326827171453048,0.266823887159565,"transcriptomics, proteomics, metabolomics",3,0,"",0.584127969187156
+"DNA inhibitor",1.08366666666667,0.190500218722534,0.352669787379634,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833
+"serotonin receptor antagonist",1.04566666666667,0.340288603002412,0.373247133137964,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833
+"CC chemokine receptor antagonist",1.04066666666667,0.364117197250189,0.326759399681463,"transcriptomics, proteomics, metabolomics",3,0,"",0.630178842242821
+"opioid receptor agonist",1.02533333333333,0.306496873284759,0.416660861555529,"transcriptomics, proteomics, metabolomics",3,0,"",0.649029418961496
+"bromodomain inhibitor",1.00833333333333,0.388469217999745,0.428500966234831,"transcriptomics, proteomics, metabolomics",3,0,"",0.650446257698751
+"NFkB pathway inhibitor",1.00066666666667,0.383198816977993,0.481197439749004,"transcriptomics, proteomics, metabolomics",3,0,"",0.696017725351238
+"DNA alkylating agent",0.995,0.427287959109545,0.413736273268339,"transcriptomics, proteomics, metabolomics",3,0,"",0.649029418961496
+"sodium channel blocker",0.99,0.293087017795057,0.530258958675574,"transcriptomics, proteomics, metabolomics",3,0,"",0.715849594212025
+"JAK inhibitor",0.982666666666667,0.281569411217436,0.515549734111053,"transcriptomics, proteomics, metabolomics",3,0,"",0.707788618016869
+"adrenergic receptor antagonist",0.943666666666667,0.253653963764285,0.635559049668344,"transcriptomics, proteomics, metabolomics",3,0,"",0.804379422236497
+"proteasome inhibitor",0.933,0.317472833483434,0.55999947357726,"transcriptomics, proteomics, metabolomics",3,0,"",0.743605858356689
+"thymidylate synthase inhibitor",0.932,1.35350360176839,0.00504301077744804,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.0816967745946582
+"progesterone receptor agonist",0.927,0.367990489007529,0.577506824057817,"transcriptomics, proteomics, metabolomics",3,0,"",0.754484721752954
+"CDK inhibitor",0.844,0.229338178243397,0.82757167059327,"transcriptomics, proteomics, metabolomics",3,0,"",0.957618647400784
+"bacterial DNA gyrase inhibitor",0.825333333333333,0.136030633804792,0.871854599105644,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541
+"dopamine receptor antagonist",0.791666666666667,0.206863078709888,0.90542642677809,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541
+"calcium channel blocker",0.791333333333333,0.118542538075297,0.91960259226323,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541
+"mTOR inhibitor",0.776666666666667,0.348495815374207,0.843673863270491,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541
+"benzodiazepine receptor agonist",0.773333333333333,0.391604817811698,0.803897232162772,"transcriptomics, proteomics, metabolomics",3,0,"",0.957583467723302
+"ribonucleotide reductase inhibitor",0.754,1.34708128930663,0.0447670838966327,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444
+"FLT3 inhibitor",0.714,1.26068552779827,0.0976371875375639,"transcriptomics, proteomics, metabolomics",3,0,"",0.329525507939278
+"cyclooxygenase inhibitor",0.641,0.115169440391104,0.992617654193712,"transcriptomics, proteomics, metabolomics",3,0,"",0.999803459608076
+"potassium channel blocker",0.588,1.16604116565411,0.31915113756098,"transcriptomics, proteomics, metabolomics",3,0,"",0.630178842242821
+"cytochrome P450 inhibitor",0.524,1.11214567391147,0.439817458216868,"transcriptomics, proteomics, metabolomics",3,0,"",0.650446257698751
+"antioxidant",0.502333333333333,1.22673401083256,0.304049914810119,"transcriptomics, proteomics, metabolomics",3,0,"",0.624513654605088
+"estrogen receptor antagonist",0.448,1.20522155639534,0.363876963065475,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833
+"phosphodiesterase inhibitor",0.433666666666667,1.17381443735087,0.441661039178165,"transcriptomics, proteomics, metabolomics",3,0,"",0.650446257698751
+"phosphatase inhibitor",0.429,1.23833073126689,0.378843242790434,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833
+"Bcr.Abl kinase inhibitor",0.396666666666667,1.58774473179203,0.0560128267928313,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444
+"HCV inhibitor",0.393333333333333,1.45822952011449,0.147756426724638,"transcriptomics, proteomics, metabolomics",3,0,"",0.427438234453418
+"glucocorticoid receptor agonist",0.358333333333333,0.880274010370256,0.818696675196103,"transcriptomics, proteomics, metabolomics",3,0,"",0.957618647400784
+"PDGFR tyrosine kinase receptor inhibitor",0.356666666666667,1.33087690389958,0.288989252911853,"transcriptomics, proteomics, metabolomics",3,0,"",0.616003407522634
+"KIT inhibitor",0.355,1.13449327895761,0.596152318363481,"transcriptomics, proteomics, metabolomics",3,0,"",0.766481552181618
+"PPAR receptor agonist",0.35,1.38924439894498,0.22404306515654,"transcriptomics, proteomics, metabolomics",3,0,"",0.504096896602216
+"Abl kinase inhibitor",0.349666666666667,1.38335112438359,0.160536038741698,"transcriptomics, proteomics, metabolomics",3,0,"",0.433447304602584
+"BCL inhibitor",0.336666666666667,1.62102848011173,0.0464684208790804,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444
+"FGFR inhibitor",0.3,1.58489747302467,0.102965841375668,"transcriptomics, proteomics, metabolomics",3,0,"",0.333609326057164
+"acetylcholine receptor antagonist",0.294333333333333,0.921609642600018,0.906789128471235,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541
+"bacterial 50S ribosomal subunit inhibitor",0.292333333333333,1.24249600938326,0.490803034982237,"transcriptomics, proteomics, metabolomics",3,0,"",0.697456944448443
+"histamine receptor antagonist",0.203,0.967905470591008,0.873078493466175,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541
+"glycogen synthase kinase inhibitor",0.145333333333333,0.943390339855849,0.918407696496075,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541
+"adrenergic receptor agonist",-0.19,0.620684299785326,0.999803459608076,"transcriptomics, proteomics, metabolomics",3,0,"",0.999803459608076
+"glutamate receptor antagonist",-0.200666666666667,1.2942106989719,0.337763993998668,"transcriptomics, proteomics, metabolomics",3,0,"",0.636253104974234
+"HSP inhibitor",-0.207333333333333,1.07157376476533,0.76820724450362,"transcriptomics, proteomics, metabolomics",3,0,"",0.957304412381435
+"MET inhibitor",-0.235666666666667,1.54887518326472,0.0635837147966158,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.285565558753444
+"estrogen receptor agonist",-0.246666666666667,0.902130995661569,0.924652387169855,"transcriptomics, proteomics, metabolomics",3,0,"",0.960215940522541
+"PI3K inhibitor",-0.249333333333333,0.811833932115019,0.970994407747962,"transcriptomics, proteomics, metabolomics",3,0,"",0.995576544652974
+"DNA methyltransferase inhibitor",-0.353333333333333,1.22414596079607,0.394009915298334,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833
+"p38 MAPK inhibitor",-0.404,1.63115541871399,0.0656656912525568,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.285565558753444
+"RET tyrosine kinase inhibitor",-0.441666666666667,1.24382809637559,0.356406295822533,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833
+"retinoid receptor agonist",-0.444,1.36105400333712,0.216414686845358,"transcriptomics, proteomics, metabolomics",3,0,"",0.500845418127828
+"VEGFR inhibitor",-0.459666666666667,0.870545997253065,0.787248929107976,"transcriptomics, proteomics, metabolomics",3,0,"",0.957583467723302
+"ALK tyrosine kinase receptor inhibitor",-0.503,1.15683490611236,0.391697866815001,"transcriptomics, proteomics, metabolomics",3,0,"",0.6382960627833
+"TGF beta receptor inhibitor",-0.576666666666667,1.66452195339483,0.029594121219828,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.239712381880607
+"tyrosine kinase inhibitor",-0.818,0.229540846038347,0.801612856650322,"transcriptomics, proteomics, metabolomics",3,0,"",0.957583467723302
+"protein tyrosine kinase inhibitor",-0.950666666666667,1.36255691012645,0.0204311970211077,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.183880773189969
+"MEK inhibitor",-1.01133333333333,0.12901679477236,0.513081914469135,"transcriptomics, proteomics, metabolomics",3,0,"",0.707788618016869
+"HDAC inhibitor",-1.06733333333333,0.615013278989432,0.170041860108312,"transcriptomics, proteomics, metabolomics",3,0,"",0.444302924799137
+"CHK inhibitor",-1.21,0.454312667664022,0.142988393629169,"transcriptomics, proteomics, metabolomics",3,0,"",0.427438234453418
+"adenosine receptor antagonist",-1.29733333333333,0.411681106359441,0.0722321335955761,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444
+"AKT inhibitor",-1.33566666666667,0.538596633236166,0.049627452949737,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.285565558753444
+"src inhibitor",-1.38,0.223383079036887,0.0585321359439333,"transcriptomics, proteomics, metabolomics",3,0,"",0.285565558753444
+"vitamin D receptor agonist",-2.08333333333333,0.410406302745625,NA,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",NA
+"EGFR inhibitor",-2.11333333333333,0.316596483450675,NA,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",NA
diff --git a/Examples/Fig3/DMEA/DMEA_results.csv b/Examples/Fig3/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..2f0becf
--- /dev/null
+++ b/Examples/Fig3/DMEA/DMEA_results.csv
@@ -0,0 +1,250 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"transcriptomics","Pearson.est","EGFR inhibitor",-0.82471,-2.33,0,1374,0.00707,"CUDC.101, AEE788, BIBU.1361, PD.153035, TAK.285, vandetanib, BIBX.1382, rociletinib, CP.724714, pelitinib, icotinib, GW.583340, WZ8040, erlotinib, afatinib, ARRY.334543, PD.168393, dacomitinib, gefitinib, XL.647, BMS.690514, neratinib, lapatinib, osimertinib, poziotinib, AZD8931, canertinib, tucatinib",Inf,2.1505805862031,TRUE
+"transcriptomics","Pearson.est","Abl kinase inhibitor",0.60551,1.46,0.0537,225,0.308,"GZD824, KW.2449, ponatinib, tozasertib, flumatinib, nilotinib",1.27002571430044,0.511449283499556,FALSE
+"transcriptomics","Pearson.est","acetylcholine receptor agonist",0.58097,1.4,0.0907,502,0.302,"oxiracetam, xanomeline, pilocarpine, tremorine",1.0423927129399,0.519993057042849,FALSE
+"transcriptomics","Pearson.est","acetylcholine receptor antagonist",0.30262,0.727,0.816,803,0.991,"iododexetimide, methscopolamine, darifenacin",0.0883098412461389,0.00392634551472468,FALSE
+"transcriptomics","Pearson.est","adenosine receptor antagonist",-0.55714,-1.54,0.0703,1427,0.249,"MRS.1220, CGS.15943",1.15304467498018,0.603800652904264,FALSE
+"transcriptomics","Pearson.est","adrenergic receptor agonist",-0.22191,-0.617,0.938,318,0.973,"buphenine, clenbuterol, oxymetazoline, midodrine, lidamidine, ritodrine, isoxsuprine, norepinephrine, isoetharine, terbutaline, metaraminol, epinephrine, A61603, methyldopa, xylazine",0.0277971616209356,0.0118871597316481,FALSE
+"transcriptomics","Pearson.est","adrenergic receptor antagonist",0.44946,1.08,0.376,525,0.664,"oxprenolol, idazoxan, atipamezole, carvedilol, naftidrofuryl, vincamine, levobunolol, metoprolol",0.424812155072339,0.177831920631982,FALSE
+"transcriptomics","Pearson.est","AKT inhibitor",-0.58362,-1.7,0.0408,1336,0.212,"triciribine, CCT128930, GSK2110183, uprosertib, GDC.0068",1.38933983691012,0.673664139071249,TRUE
+"transcriptomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.34351,0.831,0.683,148,0.91,"DMH1, AZD3463",0.165579296318467,0.0409586076789064,FALSE
+"transcriptomics","Pearson.est","androgen receptor antagonist",0.60467,1.46,0.063,480,0.308,"nilutamide, RU.58841, bicalutamide, cyproterone.acetate",1.20065945054642,0.511449283499556,FALSE
+"transcriptomics","Pearson.est","antioxidant",0.51222,1.26,0.185,671,0.396,"trolox, mesna, chlorogenic.acid, benfotiamine, taurine",0.732828271596986,0.402304814074488,FALSE
+"transcriptomics","Pearson.est","AP inhibitor",0.381,0.918,0.587,96,0.823,"idronoxil",0.231361898752386,0.0846001647877302,FALSE
+"transcriptomics","Pearson.est","ATPase inhibitor",0.4364,1.05,0.405,323,0.711,"digoxin, evodiamine, blebbistatin...., ouabain, digitoxigenin, digitoxin",0.392544976785331,0.148130399270234,FALSE
+"transcriptomics","Pearson.est","Aurora kinase inhibitor",0.62133,1.51,0.0448,251,0.35,"PF.03814735, AT.9283, barasertib, SNS.314, AMG900, KW.2449, hesperadin, danusertib, ENMD.2076, tozasertib, alisertib, GSK1070916, barasertib.HQPA",1.34872198600186,0.455931955649724,FALSE
+"transcriptomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.3898,0.937,0.578,768,0.803,"valnemulin, radezolid, dirithromycin, azalomycin.b, tedizolid, tilmicosin",0.238072161579471,0.095284454721319,FALSE
+"transcriptomics","Pearson.est","bacterial DNA gyrase inhibitor",0.39298,0.963,0.524,198,0.808,"novobiocin, finafloxacin",0.280668713016273,0.0925886392254138,FALSE
+"transcriptomics","Pearson.est","BCL inhibitor",0.57908,1.39,0.0801,235,0.303,"TW.37, gossypol, venetoclax",1.09636748391576,0.518557371497695,FALSE
+"transcriptomics","Pearson.est","Bcr.Abl kinase inhibitor",0.66348,1.57,0.036,225,0.306,"GZD824, ponatinib, tozasertib, flumatinib, nilotinib",1.44369749923271,0.51427857351842,FALSE
+"transcriptomics","Pearson.est","benzodiazepine receptor agonist",0.20268,0.489,0.984,596,0.998,"eprinomectin, zaleplon, temazepam, ivermectin, ZK.93423",0.00700490156865849,0.000869458712628891,FALSE
+"transcriptomics","Pearson.est","bromodomain inhibitor",0.27519,0.665,0.88,800,0.972,"bromosporine, PFI.1, I.BET.762",0.0555173278498314,0.0123337350737254,FALSE
+"transcriptomics","Pearson.est","calcium channel blocker",0.27812,0.671,0.872,370,0.983,"carboxyamidotriazole, cinnarazine, pranidipine",0.0594835150674328,0.00744648216786438,FALSE
+"transcriptomics","Pearson.est","CC chemokine receptor antagonist",0.5806,1.41,0.0856,490,0.339,"UNBS.5162, SB.225002, navarixin, PF.04136309, RS.504393, MK.0812",1.06752623532285,0.469800301796918,FALSE
+"transcriptomics","Pearson.est","CDK inhibitor",0.40186,0.958,0.525,406,0.799,"palbociclib, abemaciclib, AZD5438, PHA.848125, R547, indisulam, ribociclib, kenpaullone, JNJ.7706621, BMS.265246",0.279840696594043,0.0974532206860086,FALSE
+"transcriptomics","Pearson.est","CHK inhibitor",-0.33033,-0.89,0.557,476,0.792,"SB.218078, PF.477736, AZD7762, CHIR.124, SCH.900776, LY2606368, LY2603618",0.254144804826271,0.101274818410506,FALSE
+"transcriptomics","Pearson.est","cyclooxygenase inhibitor",0.30161,0.721,0.826,580,0.98,"tepoxalin, piroxicam, indoprofen, suxibuzone, meloxicam, ketoprofen, phenazone, FR.122047",0.0830199526796178,0.00877392430750515,FALSE
+"transcriptomics","Pearson.est","cytochrome P450 inhibitor",0.5096,1.23,0.21,413,0.435,"itraconazole, metyrapone, cobicistat, morin",0.677780705266081,0.361510743045363,FALSE
+"transcriptomics","Pearson.est","DNA alkylating agent",0.52809,1.29,0.174,368,0.402,"melphalan, carboplatin, carmustine, streptozotocin, TH.302, temozolomide, mitomycin.c",0.7594507517174,0.39577394691553,FALSE
+"transcriptomics","Pearson.est","DNA inhibitor",0.41865,1.01,0.45,638,0.725,"melphalan, valrubicin, carboplatin, carmustine, teroxirone, chlorambucil, oxaliplatin, nimorazole, tirapazamine, pibenzimol, mechlorethamine",0.346787486224656,0.139661993429006,FALSE
+"transcriptomics","Pearson.est","DNA methyltransferase inhibitor",-0.36253,-1.04,0.347,1371,0.623,"azacitidine, SGI.1027",0.459670525209126,0.20551195334083,FALSE
+"transcriptomics","Pearson.est","DNA polymerase inhibitor",0.60364,1.43,0.0823,236,0.322,"idoxuridine, trifluridine, foscarnet",1.08460016478773,0.492144128304169,FALSE
+"transcriptomics","Pearson.est","DNA synthesis inhibitor",0.56425,1.37,0.121,373,0.309,"anisomycin, floxuridine, cyclocytidine, CB.10.277, azodicarbonamide, nelarabine, mitomycin.c, artesunate",0.91721462968355,0.510041520575165,FALSE
+"transcriptomics","Pearson.est","dopamine receptor antagonist",0.36056,0.882,0.638,603,0.875,"raclopride, amisulpride, paliperidone, UH.232...., thioproperazine, isofloxythepin, sertindole, domperidone, mesoridazine",0.195179321278838,0.0579919469776868,FALSE
+"transcriptomics","Pearson.est","estrogen receptor agonist",0.32797,0.794,0.742,640,0.933,"estrone, PPT, estradiol, ethinyl.estradiol",0.129596094720973,0.0301183562535,FALSE
+"transcriptomics","Pearson.est","estrogen receptor antagonist",0.33908,0.811,0.728,506,0.925,"fulvestrant, danazol",0.137868620686963,0.0338582672609674,FALSE
+"transcriptomics","Pearson.est","FGFR inhibitor",0.50189,1.2,0.25,402,0.477,"dovitinib, regorafenib, erdafitinib, nintedanib, MK.2461",0.602059991327962,0.321481620959886,FALSE
+"transcriptomics","Pearson.est","FLT3 inhibitor",0.63527,1.53,0.0501,392,0.351,"dovitinib, KW.2449, ponatinib, TG.101348, ENMD.2076, tozasertib, quizartinib, gilteritinib, midostaurin, sunitinib, lestaurtinib, sorafenib",1.30016227413275,0.454692883534176,FALSE
+"transcriptomics","Pearson.est","glucocorticoid receptor agonist",0.16994,0.413,0.994,629,0.997,"fluticasone.propionate, prednisolone, hydrocortisone, rimexolone, fluocinolone.acetonide, halobetasol.propionate, triamcinolone, prednisolone.acetate",0.00261361560268669,0.00130484168834428,FALSE
+"transcriptomics","Pearson.est","glutamate receptor antagonist",-0.4446,-1.29,0.144,638,0.39,"ACDPP, MTPG, diazooxonorleucine, SIB.1757, tiletamine, IEM1754, JNJ.16259685, CPP, latrepirdine, felbamate, kynurenic.acid, CGP.37849, LY456236",0.84163750790475,0.408935392973501,FALSE
+"transcriptomics","Pearson.est","glycogen synthase kinase inhibitor",0.28675,0.69,0.873,430,0.98,"tideglusib, kenpaullone, TWS.119",0.0589857562944303,0.00877392430750515,FALSE
+"transcriptomics","Pearson.est","growth factor receptor inhibitor",0.6058,1.44,0.0804,388,0.323,"PHA.848125, danusertib, AZD3463, GSK1838705A, lestaurtinib",1.09474395125155,0.490797477668897,FALSE
+"transcriptomics","Pearson.est","HCV inhibitor",0.52227,1.27,0.171,207,0.406,"narlaprevir, mericitabine",0.767003889607846,0.391473966422806,FALSE
+"transcriptomics","Pearson.est","HDAC inhibitor",-0.43359,-1.29,0.162,617,0.39,"dacinostat, entinostat, belinostat, resminostat, RG2833, trichostatin.a, scriptaid, RGFP966, AR.42, NSC.3852, R306465, chidamide, givinostat, nexturastat.a, ACY.1215, PCI.24781, vorinostat, M.344, SB.939, panobinostat, pyroxamide, romidepsin, tacedinaline, JNJ.26481585, mocetinostat",0.790484985457369,0.408935392973501,FALSE
+"transcriptomics","Pearson.est","histamine receptor antagonist",0.28671,0.694,0.849,658,0.993,"pheniramine, cimetidine, tiotidine, nizatidine, famotidine, zolantidine, ICI.162846, BF2.649, astemizole",0.0710923097560473,0.00305075150461883,FALSE
+"transcriptomics","Pearson.est","HMGCR inhibitor",0.80486,1.94,0.00123,104,0.024,"fluvastatin, atorvastatin, mevastatin, pitavastatin",2.9100948885606,1.61978875828839,TRUE
+"transcriptomics","Pearson.est","HSP inhibitor",0.42561,1.03,0.427,261,0.737,"SNX.2112, NVP.AUY922, NMS.E973, PU.H71, ganetespib",0.369572124974976,0.132532512140949,FALSE
+"transcriptomics","Pearson.est","JAK inhibitor",0.46895,1.13,0.3,145,0.59,"AT.9283, AZ960, TG.101348, TG.101209, tozasertib",0.522878745280338,0.229147988357856,FALSE
+"transcriptomics","Pearson.est","KIT inhibitor",0.41165,1.01,0.456,765,0.725,"KI.8751, regorafenib, pazopanib, OSI.930, midostaurin, sunitinib, sorafenib, masitinib, cediranib, tandutinib, motesanib, vatalanib, lenvatinib",0.341035157335565,0.139661993429006,FALSE
+"transcriptomics","Pearson.est","MDM inhibitor",0.86919,2.08,0,191,0.00384,"idasanutlin, nutlin.3, serdemetan, AMG.232, CGM097",Inf,2.41566877563247,TRUE
+"transcriptomics","Pearson.est","MEK inhibitor",-0.29881,-0.874,0.577,427,0.764,"arctigenin, U.0126, PD.0325901, PD.318088, refametinib, nobiletin, AZD8330, Ro.4987655, TAK.733, cobimetinib, PD.184352, PD.198306, AS.703026, MEK162, selumetinib, PD.98059, MEK1.2.inhibitor, trametinib, BIX.02188",0.238824186844269,0.11690664142431,FALSE
+"transcriptomics","Pearson.est","MET inhibitor",0.31428,0.762,0.786,238,0.962,"LY2801653, PHA.665752",0.104577453960592,0.0168249279621871,FALSE
+"transcriptomics","Pearson.est","microtubule inhibitor",0.74948,1.83,0.00596,249,0.065,"vinblastine, vinflunine, secnidazole, podophyllotoxin, D.64131, cabazitaxel",2.22475374025976,1.18708664335714,TRUE
+"transcriptomics","Pearson.est","mTOR inhibitor",0.35239,0.854,0.657,693,0.889,"ku.0063794, torin.1, AZD8055, NVP.BEZ235, WYE.354, MLN0128, WAY.600, PKI.179, deforolimus, XL388, LY3023414, AZD2014, palomid.529, PF.04691502, LY303511, voxtalisib, SB.2343",0.182434630440219,0.0510982390297863,FALSE
+"transcriptomics","Pearson.est","NFkB pathway inhibitor",0.23578,0.572,0.958,549,1,"betulinic.acid, bortezomib, BAY.11.7082, EVP4593",0.0186344909214556,0,FALSE
+"transcriptomics","Pearson.est","opioid receptor agonist",0.55941,1.35,0.131,466,0.327,"trimebutine, cebranopadol, salvinorin.a, spiradoline",0.882728704344236,0.485452247339714,FALSE
+"transcriptomics","Pearson.est","p38 MAPK inhibitor",-0.30326,-0.872,0.633,437,0.717,"skepinone.l, SB.242235, VX.702, TAK.715, CMPD.1, SB.239063, talmapimod",0.198596289982645,0.1444808443322,FALSE
+"transcriptomics","Pearson.est","PARP inhibitor",0.57655,1.37,0.11,602,0.309,"talazoparib, AG.14361, niraparib, olaparib, E7449, PJ.34, AZD2461",0.958607314841775,0.510041520575165,FALSE
+"transcriptomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.45968,1.11,0.339,392,0.615,"KI.8751, dovitinib, crenolanib, ponatinib, regorafenib, pazopanib, CP.673451, axitinib, nintedanib, sunitinib, sorafenib",0.469800301796918,0.211124884224583,FALSE
+"transcriptomics","Pearson.est","phosphatase inhibitor",0.42138,1.01,0.459,522,0.725,"GSK2830371, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, CID.5458317, BVT.948",0.338187314462739,0.139661993429006,FALSE
+"transcriptomics","Pearson.est","phosphodiesterase inhibitor",0.35736,0.866,0.627,337,0.885,"GSK256066, anagrelide, YM.976",0.202732459169284,0.0530567293021746,FALSE
+"transcriptomics","Pearson.est","PI3K inhibitor",-0.21553,-0.631,0.913,1367,1,"CH5132799, PF.05212384, alpelisib, taselisib",0.039529222465701,0,FALSE
+"transcriptomics","Pearson.est","PLK inhibitor",0.73976,1.77,0.00611,382,0.0891,"rigosertib, volasertib, GSK461364, NMS.1286937, BI.2536, HMN.214, GW.843682X",2.21395878975745,1.05012229596313,TRUE
+"transcriptomics","Pearson.est","potassium channel blocker",0.50069,1.19,0.254,726,0.482,"meglitinide, dofetilide, ML133, oleoylethanolamide, ibutilide, mepivacaine",0.595166283380062,0.31695296176115,FALSE
+"transcriptomics","Pearson.est","PPAR receptor agonist",-0.43928,-1.25,0.186,633,0.395,"ciprofibrate, clofibrate, oleoylethanolamide, GW.501516, fenofibrate, S26948, pterostilbene",0.730487055782084,0.40340290437354,FALSE
+"transcriptomics","Pearson.est","progesterone receptor agonist",0.21279,0.511,0.98,772,1,"tanaproget, danazol, nomegestrol.acetate, norethindrone, dienogest",0.00877392430750515,0,FALSE
+"transcriptomics","Pearson.est","proteasome inhibitor",0.52318,1.26,0.165,369,0.396,"MG.132, ixazomib, bortezomib",0.782516055786094,0.402304814074488,FALSE
+"transcriptomics","Pearson.est","protein synthesis inhibitor",0.58007,1.4,0.0889,119,0.302,"mercaptopurine, anguidine, homoharringtonine, cycloheximide, brefeldin.a, harringtonine",1.05109823902979,0.519993057042849,FALSE
+"transcriptomics","Pearson.est","protein tyrosine kinase inhibitor",-0.58296,-1.63,0.0433,1354,0.219,"BMS.599626, AV.412, CP.724714",1.36351210364663,0.659555885159882,TRUE
+"transcriptomics","Pearson.est","RAF inhibitor",0.59544,1.47,0.0662,526,0.369,"regorafenib, dabrafenib, SB.590885, GDC.0879, RAF265, vemurafenib, sorafenib, TAK.632, LGX818, CEP.32496, PLX.4720",1.1791420105603,0.43297363384094,FALSE
+"transcriptomics","Pearson.est","RET tyrosine kinase inhibitor",0.39031,0.955,0.531,392,0.787,"regorafenib, sunitinib, sorafenib",0.274905478918531,0.104025267640935,FALSE
+"transcriptomics","Pearson.est","retinoid receptor agonist",-0.3375,-0.962,0.468,486,0.715,"adarotene, bexarotene, fenretinide, LE.135, tamibarotene, adapalene, AM.580, CD.437",0.329754146925876,0.145693958198919,FALSE
+"transcriptomics","Pearson.est","ribonucleotide reductase inhibitor",0.65753,1.62,0.0271,394,0.253,"clofarabine, cladribine, triapine, fludarabine.phosphate, LY2334737, pentostatin, gemcitabine, fludarabine",1.56703070912559,0.596879478824182,FALSE
+"transcriptomics","Pearson.est","serotonin receptor agonist",0.57158,1.4,0.0956,410,0.302,"aripiprazole, NAN.190, SR.57227A, ipsapirone",1.0195421077239,0.519993057042849,FALSE
+"transcriptomics","Pearson.est","serotonin receptor antagonist",0.5316,1.29,0.173,460,0.402,"aripiprazole, SB.200646, paliperidone, lerisetron, pirenperone, SB.216641, sertindole",0.761953896871205,0.39577394691553,FALSE
+"transcriptomics","Pearson.est","sodium channel blocker",0.27088,0.66,0.88,264,0.96,"butamben, quinidine, ajmaline",0.0555173278498314,0.0177287669604316,FALSE
+"transcriptomics","Pearson.est","src inhibitor",-0.39641,-1.2,0.22,1412,0.423,"ZM.306416, saracatinib",0.657577319177794,0.373659632624958,FALSE
+"transcriptomics","Pearson.est","sterol demethylase inhibitor",0.53593,1.28,0.18,619,0.404,"posaconazole, ketoconazole, chlormidazole, lanoconazole",0.744727494896694,0.393618634889395,FALSE
+"transcriptomics","Pearson.est","TGF beta receptor inhibitor",-0.47357,-1.32,0.156,1362,0.475,"LY2109761, repsox",0.806875401645538,0.323306390375133,FALSE
+"transcriptomics","Pearson.est","thymidylate synthase inhibitor",0.7991,1.95,0.00126,189,0.0322,"trifluridine, raltitrexed, carmofur, ftorafur",2.89962945488244,1.49214412830417,TRUE
+"transcriptomics","Pearson.est","topoisomerase inhibitor",0.60559,1.46,0.065,171,0.308,"idarubicin, topotecan, teniposide, TAS.103, amsacrine, voreloxin, etoposide.phosphate, valrubicin, nemorubicin, daunorubicin, rubitecan, amonafide, doxorubicin",1.18708664335714,0.511449283499556,FALSE
+"transcriptomics","Pearson.est","tubulin polymerization inhibitor",0.62294,1.48,0.0675,295,0.383,"verubulin, vinblastine, taltobulin, BNC105, combretastatin.A.4, vindesine, KX2.391, CYT.997, fosbretabulin, podophyllotoxin, dolastatin.10, vincristine, epothilone.b, albendazole, ABT.751, vinorelbine, docetaxel, plinabulin",1.17069622716898,0.416801226031377,FALSE
+"transcriptomics","Pearson.est","tyrosine kinase inhibitor",-0.20581,-0.591,0.956,1354,0.938,"BMS.599626, AV.412, vandetanib, CP.724714",0.0195421077238999,0.0277971616209356,FALSE
+"transcriptomics","Pearson.est","VEGFR inhibitor",0.21469,0.515,0.977,402,1,"KI.8751, dovitinib, regorafenib, ENMD.2076, pazopanib, axitinib, OSI.930, nintedanib, RAF265, sunitinib, sorafenib, MK.2461",0.0101054362812269,0,FALSE
+"transcriptomics","Pearson.est","vitamin D receptor agonist",-0.81854,-2.34,0,1312,0.013,"tacalcitol, calcitriol, paricalcitol, maxacalcitol",Inf,1.88605664769316,TRUE
+"proteomics","Pearson.est","EGFR inhibitor",-0.86578,-2.26,0,1383,0.00205,"GW.583340, AEE788, CUDC.101, rociletinib, TAK.285, PD.153035, icotinib, CP.724714, WZ.4002, BIBU.1361, vandetanib, BMS.599626, PD.168393, ARRY.334543, AST.1306, WZ8040, gefitinib, XL.647, erlotinib, neratinib, tucatinib, lapatinib, BMS.690514, pelitinib, AZD8931, dacomitinib, poziotinib, afatinib, canertinib, osimertinib",Inf,2.68824613894425,TRUE
+"proteomics","Pearson.est","Abl kinase inhibitor",0.33477,0.789,0.734,351,0.82,"nilotinib, GZD824, tozasertib, bafetinib, ponatinib, KW.2449",0.134303940083929,0.0861861476162833,FALSE
+"proteomics","Pearson.est","acetylcholine receptor agonist",0.52774,1.25,0.209,687,0.551,"nicotine, tremorine, xanomeline, nefiracetam, oxiracetam, pilocarpine",0.679853713888946,0.258848401148215,FALSE
+"proteomics","Pearson.est","acetylcholine receptor antagonist",0.39259,0.92,0.581,574,0.688,"methscopolamine, diphemanil, iododexetimide, darifenacin",0.235823867609669,0.162411561764489,FALSE
+"proteomics","Pearson.est","adenosine receptor antagonist",-0.57668,-1.53,0.0649,1409,0.225,"MRS.1220, CGS.15943",1.18775530319963,0.647817481888638,FALSE
+"proteomics","Pearson.est","adrenergic receptor agonist",-0.18233,-0.475,0.985,1081,1,"oxymetazoline, isoetharine, ritodrine, epinephrine, lidamidine, terbutaline, methyldopa, midodrine, isoxsuprine",0.00656376950238827,0,FALSE
+"proteomics","Pearson.est","adrenergic receptor antagonist",0.27701,0.651,0.896,488,0.949,"idazoxan, carvedilol, oxprenolol, levobunolol, metoprolol, atenolol......, naftidrofuryl",0.0476919903378748,0.0227337875727074,FALSE
+"proteomics","Pearson.est","AKT inhibitor",-0.62476,-1.59,0.0578,1308,0.198,"uprosertib, GSK2110183, triciribine, CCT128930, AZD5363",1.23807216157947,0.703334809738469,FALSE
+"proteomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41969,-1.11,0.314,1258,0.807,"CEP.37440, GW.788388, NVP.TAE684, SB.505124, AP26113, brigatinib",0.503070351926785,0.0931264652779296,FALSE
+"proteomics","Pearson.est","androgen receptor antagonist",0.38972,0.924,0.57,512,0.696,"nilutamide, flutamide",0.244125144327509,0.157390760389438,FALSE
+"proteomics","Pearson.est","antioxidant",0.49166,1.16,0.273,446,0.572,"taurine, mesna, trolox",0.563837352959244,0.242603971206976,FALSE
+"proteomics","Pearson.est","AP inhibitor",0.51096,1.2,0.264,608,0.591,"idronoxil, GDC.0152, LCL.161, birinapant, embelin",0.578396073130169,0.228412519118745,FALSE
+"proteomics","Pearson.est","ATPase inhibitor",0.59758,1.44,0.09,233,0.595,"digoxin, oligomycin.a, digitoxigenin, NMS.873, evodiamine, k.strophanthidin",1.04575749056068,0.22548303427145,FALSE
+"proteomics","Pearson.est","Aurora kinase inhibitor",0.57358,1.35,0.13,358,0.513,"MK.5108, barasertib, barasertib.HQPA, SNS.314, AMG900, MK.8745, danusertib, tozasertib, CCT137690, ENMD.2076, hesperadin, AT.9283, KW.2449, PF.03814735",0.886056647693163,0.289882634888184,FALSE
+"proteomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.45114,1.08,0.387,222,0.574,"valnemulin, radezolid",0.412289034981089,0.241088107602027,FALSE
+"proteomics","Pearson.est","bacterial DNA gyrase inhibitor",0.35173,0.822,0.677,810,0.806,"lomefloxacin, novobiocin, sparfloxacin, nadifloxacin, finafloxacin, norfloxacin",0.169411331314856,0.0936649581949093,FALSE
+"proteomics","Pearson.est","BCL inhibitor",0.48376,1.15,0.305,89,0.573,"gossypol, TW.37",0.515700160653214,0.24184537803261,FALSE
+"proteomics","Pearson.est","Bcr.Abl kinase inhibitor",0.44083,1.03,0.437,323,0.605,"nilotinib, GZD824, tozasertib, bafetinib, ponatinib",0.359518563029578,0.218244625347531,FALSE
+"proteomics","Pearson.est","benzodiazepine receptor agonist",0.25994,0.611,0.915,685,0.967,"bentazepam, nefiracetam, lorazepam, indiplon, zaleplon",0.0385789059335517,0.0145735259169983,FALSE
+"proteomics","Pearson.est","bromodomain inhibitor",0.39787,0.93,0.557,525,0.701,"bromosporine, OTX015",0.254144804826271,0.154281982033341,FALSE
+"proteomics","Pearson.est","calcium channel blocker",0.33847,0.795,0.727,184,0.827,"carboxyamidotriazole, pranidipine",0.138465589140962,0.0824944904474534,FALSE
+"proteomics","Pearson.est","CC chemokine receptor antagonist",0.43271,1.03,0.433,235,0.605,"SB.225002, UNBS.5162",0.363512103646635,0.218244625347531,FALSE
+"proteomics","Pearson.est","CDK inhibitor",0.42795,0.994,0.476,545,0.638,"abemaciclib, palbociclib, PHA.848125, R547, JNJ.7706621, NU6027, dinaciclib, PHA.793887, ribociclib, AZD5438, BMS.265246, indisulam",0.322393047279507,0.195179321278838,FALSE
+"proteomics","Pearson.est","CHK inhibitor",-0.38712,-1.01,0.417,1242,0.803,"CHIR.124, LY2603618",0.379863945026242,0.095284454721319,FALSE
+"proteomics","Pearson.est","cyclooxygenase inhibitor",0.21637,0.509,0.975,327,0.976,"tepoxalin, piroxicam, sulfasalazine, suxibuzone",0.0109953843014632,0.0105501823333082,FALSE
+"proteomics","Pearson.est","cytochrome P450 inhibitor",0.46704,1.1,0.349,594,0.583,"cobicistat, PF.4981517, metyrapone, clotrimazole",0.45717457304082,0.234331445240986,FALSE
+"proteomics","Pearson.est","DNA alkylating agent",0.51533,1.19,0.283,347,0.568,"carboplatin, carmustine, dianhydrogalactitol, mitomycin.c, cisplatin, temozolomide, melphalan, TH.302",0.54821356447571,0.245651664288981,FALSE
+"proteomics","Pearson.est","DNA inhibitor",0.55777,1.3,0.147,277,0.513,"carboplatin, chlorambucil, valrubicin, carmustine, pibenzimol, oxaliplatin, teroxirone, melphalan",0.832682665251824,0.289882634888184,FALSE
+"proteomics","Pearson.est","DNA methyltransferase inhibitor",0.45092,1.06,0.39,7,0.582,"disulfiram",0.408935392973501,0.235077015350112,FALSE
+"proteomics","Pearson.est","DNA polymerase inhibitor",0.48547,1.14,0.3,381,0.556,"foscarnet, idoxuridine, trifluridine, menadione",0.522878745280338,0.254925208417942,FALSE
+"proteomics","Pearson.est","DNA synthesis inhibitor",0.55464,1.31,0.145,578,0.518,"cyclocytidine, mitomycin.c, cisplatin, floxuridine, CB.10.277, altretamine, anisomycin, artesunate, enocitabine, azodicarbonamide, artemisinin",0.838631997765025,0.285670240254767,FALSE
+"proteomics","Pearson.est","dopamine receptor antagonist",0.2375,0.555,0.952,590,0.989,"raclopride, amisulpride, paliperidone, nemonapride, sertindole, isofloxythepin, thioproperazine, UH.232....",0.0213630516155257,0.0048037084028206,FALSE
+"proteomics","Pearson.est","estrogen receptor agonist",-0.27569,-0.727,0.772,397,0.951,"estradiol.cypionate, PPT, estradiol, estrone, ethinyl.estradiol, erteberel, levonorgestrel, equol",0.112382699664264,0.0218194830625861,FALSE
+"proteomics","Pearson.est","estrogen receptor antagonist",-0.33843,-0.897,0.551,1314,0.851,"raloxifene, clomifene, tamoxifen",0.258848401148215,0.0700704399154121,FALSE
+"proteomics","Pearson.est","FGFR inhibitor",0.53541,1.23,0.194,292,0.571,"erdafitinib, regorafenib, dovitinib, nintedanib, lenvatinib",0.712198270069774,0.243363891754152,FALSE
+"proteomics","Pearson.est","FLT3 inhibitor",0.56887,1.35,0.125,484,0.513,"TG.101348, dovitinib, tozasertib, sorafenib, ENMD.2076, tyrphostin.AG.1296, ponatinib, KW.2449, gilteritinib, GTP.14564, lestaurtinib",0.903089986991944,0.289882634888184,FALSE
+"proteomics","Pearson.est","glucocorticoid receptor agonist",-0.21561,-0.548,0.961,440,1,"dexamethasone.acetate, halcinonide, triamcinolone, beclomethasone.dipropionate, halobetasol.propionate, desonide, flumethasone.pivalate, rimexolone, prednisolone.hemisuccinate, piretanide, prednisolone, difluprednate, fluorometholone, methylprednisolone, deflazacort, fluocinolone.acetonide, clobetasol.propionate, flumethasone, prednisolone.acetate, fludroxycortide, ciclesonide, betamethasone, hydrocortisone, triamcinolone.acetonide",0.0172766123314547,0,FALSE
+"proteomics","Pearson.est","glutamate receptor antagonist",-0.2087,-0.542,0.972,1406,1,"latrepirdine",0.0123337350737254,0,FALSE
+"proteomics","Pearson.est","glycogen synthase kinase inhibitor",-0.36762,-0.944,0.49,529,0.877,"CHIR.99021, tideglusib, CHIR.98014, TWS.119, kenpaullone, GSK.3.inhibitor.IX, indirubin, AZD2858, LY2090314",0.309803919971486,0.0570004066339595,FALSE
+"proteomics","Pearson.est","growth factor receptor inhibitor",0.42278,0.99,0.489,195,0.632,"PHA.848125, danusertib",0.31069114087638,0.199282921717615,FALSE
+"proteomics","Pearson.est","HCV inhibitor",0.49852,1.2,0.266,608,0.591,"mericitabine, narlaprevir, Ro.9187, embelin",0.575118363368933,0.228412519118745,FALSE
+"proteomics","Pearson.est","HDAC inhibitor",-0.14547,-0.372,0.996,207,0.999,"NSC.3852, chidamide, RGFP966, dacinostat, resminostat, ACY.1215, pyroxamide, entinostat, nexturastat.a, AR.42, M.344, trichostatin.a, scriptaid, belinostat, R306465, PCI.24781, givinostat, RG2833, romidepsin, vorinostat, tacedinaline, SB.939, mocetinostat, panobinostat, JNJ.26481585",0.00174066157630127,0.000434511774017692,FALSE
+"proteomics","Pearson.est","histamine receptor antagonist",-0.34552,-0.912,0.526,1294,0.879,"levocetirizine, ebastine, ranitidine, terfenadine, zolantidine, chloropyramine",0.279014255846261,0.0560111249262281,FALSE
+"proteomics","Pearson.est","HMGCR inhibitor",0.85397,1.99,0.0014,90,0.0228,"mevastatin, atorvastatin, fluvastatin, pitavastatin",2.85387196432176,1.64206515299955,TRUE
+"proteomics","Pearson.est","HSP inhibitor",-0.30589,-0.821,0.656,1275,0.89,"VER.49009, KW.2478, guanidine, alvespimycin, tanespimycin",0.18309616062434,0.0506099933550872,FALSE
+"proteomics","Pearson.est","JAK inhibitor",0.49239,1.16,0.281,338,0.572,"AZ960, TG.101348, baricitinib, WHI.P154, TG.101209, tozasertib, AT.9283",0.55129368009492,0.242603971206976,FALSE
+"proteomics","Pearson.est","KIT inhibitor",0.43143,1.01,0.47,339,0.625,"pazopanib, regorafenib, KI.8751, sorafenib, lenvatinib, motesanib",0.327902142064283,0.204119982655925,FALSE
+"proteomics","Pearson.est","MDM inhibitor",0.67888,1.57,0.0299,88,0.522,"AMG.232, idasanutlin, nutlin.3",1.52432881167557,0.282329496997738,FALSE
+"proteomics","Pearson.est","MEK inhibitor",-0.39583,-1.03,0.436,1131,0.827,"cobimetinib, Ro.4987655, selumetinib, nobiletin, PD.184352, AS.703026, TAK.733, trametinib, AZD8330",0.360513510731414,0.0824944904474534,FALSE
+"proteomics","Pearson.est","MET inhibitor",0.23292,0.551,0.967,670,0.974,"PHA.665752, AMG458, LY2801653, NVP.BVU972",0.0145735259169983,0.0114410431213845,FALSE
+"proteomics","Pearson.est","microtubule inhibitor",0.60121,1.41,0.0924,286,0.563,"vinblastine, vinflunine, D.64131, triclabendazole",1.03432802877989,0.249491605148654,FALSE
+"proteomics","Pearson.est","mTOR inhibitor",0.45668,1.08,0.394,334,0.574,"ku.0063794, XL388, deforolimus, MLN0128, WAY.600, AZD2014, torin.1, PI.103, PF.04691502, PP242, NVP.BEZ235",0.404503778174426,0.241088107602027,FALSE
+"proteomics","Pearson.est","NFkB pathway inhibitor",0.47031,1.12,0.349,364,0.578,"EVP4593, betulinic.acid, BAY.11.7082, parthenolide",0.45717457304082,0.238072161579471,FALSE
+"proteomics","Pearson.est","opioid receptor agonist",0.41435,0.985,0.485,312,0.626,"trimebutine, spiradoline, salvinorin.a",0.314258261397736,0.20342566678957,FALSE
+"proteomics","Pearson.est","p38 MAPK inhibitor",-0.68975,-1.75,0.0379,1013,0.172,"SB.242235, skepinone.l, VX.702, talmapimod, TAK.715, SB.239063",1.42136079003193,0.764471553092451,TRUE
+"proteomics","Pearson.est","PARP inhibitor",0.61495,1.43,0.0714,302,0.561,"AG.14361, talazoparib, olaparib, AZD2461, niraparib",1.14630178822383,0.251037138743839,FALSE
+"proteomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.49138,1.14,0.321,339,0.556,"pazopanib, regorafenib, axitinib, dovitinib, nintedanib, KI.8751, CP.673451, sorafenib, lenvatinib, ponatinib, motesanib",0.493494967595128,0.254925208417942,FALSE
+"proteomics","Pearson.est","phosphatase inhibitor",0.54946,1.27,0.199,6,0.557,"bis.maltolato.oxovanadium.IV., GSK2830371",0.701146923590293,0.254144804826271,FALSE
+"proteomics","Pearson.est","phosphodiesterase inhibitor",0.57887,1.33,0.161,270,0.499,"GSK256066, anagrelide, zardaverine",0.79317412396815,0.30189945437661,FALSE
+"proteomics","Pearson.est","PI3K inhibitor",0.2899,0.683,0.856,468,0.934,"idelalisib, ZSTK.474, buparlisib, AZD6482, PI.103, PF.04691502, NVP.BEZ235, BGT226, CUDC.907, GDC.0941, SB.2343, LY3023414",0.0675262353228468,0.0296531237699066,FALSE
+"proteomics","Pearson.est","PLK inhibitor",0.74671,1.76,0.00533,305,0.232,"volasertib, rigosertib, GW.843682X, BI.2536, NMS.1286937, GSK461364",2.27327279097343,0.6345120151091,TRUE
+"proteomics","Pearson.est","potassium channel blocker",0.57492,1.33,0.152,456,0.499,"ML133, ibutilide, dofetilide, mepivacaine",0.818156412055227,0.30189945437661,FALSE
+"proteomics","Pearson.est","PPAR receptor agonist",0.54565,1.25,0.213,30,0.551,"clofibrate",0.671620396561262,0.258848401148215,FALSE
+"proteomics","Pearson.est","progesterone receptor agonist",0.4516,1.06,0.383,142,0.582,"norethindrone, tanaproget, nomegestrol.acetate",0.416801226031377,0.235077015350112,FALSE
+"proteomics","Pearson.est","proteasome inhibitor",0.39205,0.913,0.577,95,0.686,"MG.132",0.238824186844269,0.163675884293248,FALSE
+"proteomics","Pearson.est","protein synthesis inhibitor",0.59329,1.4,0.114,352,0.497,"mercaptopurine, harringtonine, anguidine, homoharringtonine, thiostrepton, clofoctol, emetine, cycloheximide, bruceantin",0.943095148663527,0.303643611266668,FALSE
+"proteomics","Pearson.est","protein tyrosine kinase inhibitor",-0.69758,-1.84,0.0144,1418,0.151,"CP.724714, BMS.599626, AV.412",1.84163750790475,0.821023052706831,TRUE
+"proteomics","Pearson.est","RAF inhibitor",0.721,1.69,0.00824,354,0.285,"regorafenib, TAK.632, SB.590885, RAF265, dabrafenib, vemurafenib, sorafenib, AZ.628, LGX818, PLX.4720, GDC.0879",2.08407278830288,0.54515513999149,FALSE
+"proteomics","Pearson.est","RET tyrosine kinase inhibitor",-0.31715,-0.85,0.622,1422,0.892,"vandetanib",0.206209615309181,0.0496351456238769,FALSE
+"proteomics","Pearson.est","retinoid receptor agonist",0.47211,1.1,0.347,166,0.583,"adapalene, fenretinide, LE.135",0.459670525209126,0.234331445240986,FALSE
+"proteomics","Pearson.est","ribonucleotide reductase inhibitor",0.60094,1.44,0.0814,200,0.595,"clofarabine, triapine, fludarabine.phosphate, cladribine, pentostatin",1.0893755951108,0.22548303427145,FALSE
+"proteomics","Pearson.est","serotonin receptor agonist",0.58925,1.4,0.114,1,0.497,"aripiprazole",0.943095148663527,0.303643611266668,FALSE
+"proteomics","Pearson.est","serotonin receptor antagonist",0.50508,1.19,0.259,183,0.568,"aripiprazole, pirenperone, lerisetron",0.586700235918748,0.245651664288981,FALSE
+"proteomics","Pearson.est","sodium channel blocker",0.46334,1.09,0.364,218,0.586,"cibenzoline, butamben, quinidine",0.438898616350944,0.232102383981909,FALSE
+"proteomics","Pearson.est","src inhibitor",-0.6257,-1.63,0.0616,1360,0.196,"bosutinib, dasatinib, ZM.306416, saracatinib",1.21041928783557,0.707743928643524,FALSE
+"proteomics","Pearson.est","sterol demethylase inhibitor",0.58924,1.37,0.109,404,0.537,"chlormidazole, posaconazole, ketoconazole",0.962573502059376,0.270025714300444,FALSE
+"proteomics","Pearson.est","TGF beta receptor inhibitor",-0.68019,-1.74,0.0374,1223,0.144,"LY2109761, D.4476, SB.431542, repsox",1.42712839779952,0.84163750790475,TRUE
+"proteomics","Pearson.est","thymidylate synthase inhibitor",0.63087,1.45,0.0806,348,0.748,"doxifluridine, trifluridine, ftorafur",1.09366495819491,0.126098402135539,FALSE
+"proteomics","Pearson.est","topoisomerase inhibitor",0.63755,1.51,0.0548,329,0.629,"etoposide.phosphate, doxorubicin, TAS.103, teniposide, voreloxin, topotecan, idarubicin, valrubicin, epirubicin, dexrazoxane, amsacrine, nemorubicin, mitoxantrone, daunorubicin, SN.38, etoposide",1.26121944151563,0.201349354554731,FALSE
+"proteomics","Pearson.est","tubulin polymerization inhibitor",0.50064,1.17,0.251,486,0.591,"BNC105, taltobulin, verubulin, vinblastine, vindesine, KX2.391, vinorelbine, fosbretabulin, combretastatin.A.4, mebendazole, epothilone.d, ABT.751, vincristine, flubendazole, fenbendazole",0.600326278518962,0.228412519118745,FALSE
+"proteomics","Pearson.est","tyrosine kinase inhibitor",-0.39451,-1.05,0.336,1372,0.862,"dasatinib, CP.724714, vandetanib, BMS.599626, AV.412",0.473660722610156,0.0644927341752872,FALSE
+"proteomics","Pearson.est","VEGFR inhibitor",-0.28031,-0.734,0.777,1391,0.992,"AEE788, vandetanib, ZM.306416, XL.647, BMS.690514",0.109578981199086,0.00348832784582135,FALSE
+"proteomics","Pearson.est","vitamin D receptor agonist",-0.86287,-2.3,0,1252,0.00102,"alfacalcidol, ercalcitriol, calcitriol, tacalcitol, paricalcitol, maxacalcitol",Inf,2.99139982823808,TRUE
+"metabolomics","Pearson.est","EGFR inhibitor",-0.63456,-1.75,0.0273,1223,0.578,"ARRY.334543, BMS.690514, WZ8040, PD.153035, BIBU.1361, salvianolic.acid.B, tyrphostin.AG.494, canertinib, erlotinib, OSI.420, afatinib, GW.583340, neratinib, rociletinib, AZD8931, TAK.285, XL.647, osimertinib, dacomitinib, icotinib, AEE788, gefitinib, pelitinib, vandetanib",1.56383735295924,0.238072161579471,FALSE
+"metabolomics","Pearson.est","Abl kinase inhibitor",-0.4422,-1.2,0.25,1285,0.587,"tozasertib, ponatinib, dasatinib",0.602059991327962,0.231361898752386,FALSE
+"metabolomics","Pearson.est","acetylcholine receptor agonist",0.53901,1.29,0.193,360,0.671,"pilocarpine, xanomeline, oxiracetam, nefiracetam",0.714442690992226,0.173277479831008,FALSE
+"metabolomics","Pearson.est","acetylcholine receptor antagonist",-0.27739,-0.764,0.725,400,0.862,"hyoscyamine, darifenacin, diphemanil, methscopolamine, iododexetimide, dicycloverine",0.139661993429006,0.0644927341752872,FALSE
+"metabolomics","Pearson.est","adenosine receptor antagonist",-0.31228,-0.822,0.673,450,0.922,"PSB.1115, theophylline, MRS.1220, sulmazole, SCH.58261, istradefylline, CGS.15943",0.171984935776023,0.0352690789463706,FALSE
+"metabolomics","Pearson.est","adrenergic receptor agonist",0.21517,0.522,0.971,477,1,"lidamidine, buphenine, xylazine, midodrine, methyldopa",0.0127807700919951,0,FALSE
+"metabolomics","Pearson.est","adrenergic receptor antagonist",0.45723,1.1,0.345,194,0.794,"prazosin, naftidrofuryl, RS.17053, imiloxan",0.462180904926726,0.100179497572904,FALSE
+"metabolomics","Pearson.est","AKT inhibitor",-0.27557,-0.717,0.774,396,0.826,"AT7867, AZD5363, GSK2110183, CCT128930, GDC.0068, ONC201, palomid.529, A.674563, uprosertib, triciribine, MK.2206",0.111259039317107,0.0830199526796178,FALSE
+"metabolomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.45618,-1.23,0.201,1097,0.577,"DMH1, AP26113, brigatinib, crizotinib, GW.788388, AZD3463, CEP.37440",0.696803942579511,0.238824186844269,FALSE
+"metabolomics","Pearson.est","androgen receptor antagonist",0.35855,0.868,0.615,121,0.998,"flutamide",0.211124884224583,0.000869458712628891,FALSE
+"metabolomics","Pearson.est","antioxidant",-0.33148,-0.913,0.545,478,0.853,"rutin, benfotiamine, mesna, trolox, taurine, chlorogenic.acid",0.263603497723358,0.069050968832477,FALSE
+"metabolomics","Pearson.est","AP inhibitor",0.53974,1.28,0.182,606,0.647,"tanshinone.i, GDC.0152, birinapant, LCL.161",0.739928612014925,0.1890957193313,FALSE
+"metabolomics","Pearson.est","ATPase inhibitor",0.42939,1.04,0.422,68,0.762,"oligomycin.a, NMS.873",0.374687549038326,0.1180450286604,FALSE
+"metabolomics","Pearson.est","Aurora kinase inhibitor",0.61922,1.5,0.0567,120,0.803,"PHA.680632, AT.9283, barasertib.HQPA, danusertib, CCT129202, SNS.314, GSK1070916, TAK.901, ZM.447439, alisertib",1.24641694110709,0.095284454721319,FALSE
+"metabolomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42133,-1.14,0.297,1397,0.582,"dirithromycin, azithromycin",0.527243550682788,0.235077015350112,FALSE
+"metabolomics","Pearson.est","bacterial DNA gyrase inhibitor",0.28297,0.691,0.82,57,1,"norfloxacin",0.0861861476162833,0,FALSE
+"metabolomics","Pearson.est","BCL inhibitor",-0.55553,-1.53,0.0683,1217,0.399,"obatoclax, navitoclax, TW.37, HA14.1, gossypol",1.16557929631847,0.399027104313252,FALSE
+"metabolomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.51582,-1.41,0.137,1285,0.427,"tozasertib, ponatinib, dasatinib",0.863279432843593,0.369572124974976,FALSE
+"metabolomics","Pearson.est","benzodiazepine receptor agonist",0.5082,1.22,0.243,407,0.665,"ZK.93423, bentazepam, gamma.aminobutyric.acid, indiplon, nefiracetam, lorazepam",0.614393726401688,0.177178354696895,FALSE
+"metabolomics","Pearson.est","bromodomain inhibitor",0.59722,1.43,0.104,583,0.779,"I.BET151, OTX015, I.BET.762, JQ1...., PFI.1",0.98296666070122,0.108462542327436,FALSE
+"metabolomics","Pearson.est","calcium channel blocker",0.37974,0.908,0.58,514,0.948,"fendiline, efonidipine.monoethanolate, pranidipine, cinnarazine, SR.33805, carboxyamidotriazole",0.236572006437063,0.0231916626619338,FALSE
+"metabolomics","Pearson.est","CC chemokine receptor antagonist",0.27693,0.682,0.841,282,1,"SB.225002, ZK811752",0.0752040042020878,0,FALSE
+"metabolomics","Pearson.est","CDK inhibitor",0.24473,0.58,0.963,423,1,"PHA.793887, R547, ribociclib, CR8..R., JNJ.7706621, arcyriaflavin.a, BMS.387032",0.0163737128754655,0,FALSE
+"metabolomics","Pearson.est","CHK inhibitor",-0.635,-1.73,0.0356,1338,0.423,"LY2603618, LY2606368, SCH.900776",1.44855000202712,0.373659632624958,FALSE
+"metabolomics","Pearson.est","cyclooxygenase inhibitor",0.28761,0.693,0.841,474,1,"naproxen, AM.404, piroxicam, metoxibutropate, FR.122047, aspirin, acetylsalicylsalicylic.acid, FK.3311",0.0752040042020878,0,FALSE
+"metabolomics","Pearson.est","cytochrome P450 inhibitor",-0.2823,-0.758,0.731,1227,0.844,"eplerenone, itraconazole",0.13608262304214,0.073657553374345,FALSE
+"metabolomics","Pearson.est","DNA alkylating agent",0.20883,0.505,0.969,531,0.998,"carboplatin, TH.302, dianhydrogalactitol, mitomycin.c, satraplatin, streptozotocin",0.0136762229492347,0.000869458712628891,FALSE
+"metabolomics","Pearson.est","DNA inhibitor",0.39273,0.941,0.539,332,0.946,"tirapazamine, busulfan, oxaliplatin, carboplatin, valrubicin, primaquine",0.268411234813261,0.0241088635982073,FALSE
+"metabolomics","Pearson.est","DNA methyltransferase inhibitor",-0.4181,-1.08,0.322,1373,0.622,"azacitidine, decitabine",0.492144128304169,0.206209615309181,FALSE
+"metabolomics","Pearson.est","DNA polymerase inhibitor",0.43964,1.05,0.393,326,0.771,"cephalomannine, famciclovir, trifluridine",0.405607449624573,0.112945621949043,FALSE
+"metabolomics","Pearson.est","DNA synthesis inhibitor",0.34522,0.831,0.687,179,1,"artemisinin, floxuridine",0.16304326294045,0,FALSE
+"metabolomics","Pearson.est","dopamine receptor antagonist",0.38897,0.938,0.562,507,0.919,"UH.232...., isofloxythepin, clebopride, lurasidone, domperidone, thioproperazine, remoxipride, oxiperomide, ziprasidone",0.250263684430939,0.0366844886138887,FALSE
+"metabolomics","Pearson.est","estrogen receptor agonist",-0.29501,-0.807,0.66,1420,0.882,"estradiol",0.180456064458131,0.0545314148681803,FALSE
+"metabolomics","Pearson.est","estrogen receptor antagonist",0.58977,1.43,0.094,460,0.779,"tamoxifen, raloxifene, clomifene, danazol",1.0268721464003,0.108462542327436,FALSE
+"metabolomics","Pearson.est","FGFR inhibitor",-0.58144,-1.53,0.105,1252,0.399,"MK.2461, lucitanib, regorafenib, erdafitinib",0.978810700930062,0.399027104313252,FALSE
+"metabolomics","Pearson.est","FLT3 inhibitor",-0.28639,-0.738,0.753,1119,0.822,"sorafenib, KW.2449, gilteritinib, sunitinib, pacritinib, tozasertib, ponatinib",0.123205023799299,0.0851281824599496,FALSE
+"metabolomics","Pearson.est","glucocorticoid receptor agonist",0.48681,1.21,0.243,582,0.617,"hydrocortisone, prednisolone, halcinonide, fluticasone.propionate, flumethasone.pivalate, dexamethasone.acetate, piretanide, fluorometholone, betamethasone, rimexolone, halobetasol.propionate, triamcinolone, deflazacort, fludroxycortide, clobetasol.propionate, methylprednisolone, ciclesonide",0.614393726401688,0.209714835966758,FALSE
+"metabolomics","Pearson.est","glutamate receptor antagonist",0.49974,1.23,0.236,421,0.728,"IEM1754, ACDPP, CPP, latrepirdine, felbamate, tiletamine, LY456236",0.627087997029893,0.137868620686963,FALSE
+"metabolomics","Pearson.est","glycogen synthase kinase inhibitor",0.28641,0.69,0.854,438,1,"CHIR.99021, CHIR.98014, TWS.119",0.068542129310995,0,FALSE
+"metabolomics","Pearson.est","growth factor receptor inhibitor",0.43831,1.07,0.381,45,0.791,"danusertib, GW.441756",0.419075024324381,0.101823516502323,FALSE
+"metabolomics","Pearson.est","HCV inhibitor",-0.4941,-1.29,0.191,1435,0.523,"Ro.9187",0.718966632752272,0.281498311132726,FALSE
+"metabolomics","Pearson.est","HDAC inhibitor",-0.57556,-1.54,0.0667,1201,0.541,"belinostat, givinostat, M.344, AR.42, chidamide, PCI.24781, entinostat, tacedinaline, dacinostat, panobinostat, resminostat, R306465, RG2833",1.17587416608345,0.266802734893431,FALSE
+"metabolomics","Pearson.est","histamine receptor antagonist",0.34081,0.827,0.655,223,1,"levocetirizine, terfenadine, ICI.162846, epinastine",0.183758700008217,0,FALSE
+"metabolomics","Pearson.est","HMGCR inhibitor",0.62652,1.53,0.0604,113,0.902,"fluvastatin, mevastatin",1.21896306137887,0.0447934624580583,FALSE
+"metabolomics","Pearson.est","HSP inhibitor",-0.31065,-0.831,0.68,1359,0.941,"BIIB021, NVP.AUY922, ganetespib",0.167491087293764,0.0264103765727431,FALSE
+"metabolomics","Pearson.est","JAK inhibitor",0.2706,0.658,0.871,325,1,"AT.9283, WHI.P154, filgotinib, TG.101348, AZ960",0.0599818449923368,0,FALSE
+"metabolomics","Pearson.est","KIT inhibitor",-0.35814,-0.955,0.468,1096,0.801,"pazopanib, motesanib, sorafenib, sunitinib, regorafenib, telatinib, dasatinib",0.329754146925876,0.0963674839157623,FALSE
+"metabolomics","Pearson.est","MDM inhibitor",0.80779,1.95,0.00144,46,0.0788,"idasanutlin, CGM097, nutlin.3, AMG.232",2.84163750790475,1.10347378251044,TRUE
+"metabolomics","Pearson.est","MEK inhibitor",-0.41557,-1.13,0.289,1278,0.566,"selumetinib, AZD8330, PD.184352, AS.703026, trametinib, cobimetinib, nobiletin",0.539102157243452,0.247183568811729,FALSE
+"metabolomics","Pearson.est","MET inhibitor",-0.75175,-2.02,0.00338,1243,0.244,"INC.280, NVP.BVU972, PHA.665752, LY2801653",2.47108329972235,0.612610173661271,TRUE
+"metabolomics","Pearson.est","microtubule inhibitor",0.57668,1.4,0.104,454,0.599,"cabazitaxel, colchicine, D.64131, podophyllotoxin, triclabendazole, vinblastine, secnidazole",0.98296666070122,0.222573177610689,FALSE
+"metabolomics","Pearson.est","mTOR inhibitor",0.1635,0.396,0.994,231,0.998,"PF.05212384, PKI.179, AZD8055, LY303511",0.00261361560268669,0.000869458712628891,FALSE
+"metabolomics","Pearson.est","NFkB pathway inhibitor",0.54292,1.31,0.191,148,0.671,"EVP4593, IKK.2.inhibitor.V, bindarit, parthenolide....",0.718966632752272,0.173277479831008,FALSE
+"metabolomics","Pearson.est","opioid receptor agonist",0.30739,0.741,0.761,196,1,"spiradoline",0.118615343229427,0,FALSE
+"metabolomics","Pearson.est","p38 MAPK inhibitor",0.58567,1.41,0.112,589,0.641,"CMPD.1, skepinone.l, SB.239063, SB.242235, VX.702, TAK.715",0.950781977329818,0.193141970481183,FALSE
+"metabolomics","Pearson.est","PARP inhibitor",0.44842,1.09,0.353,530,0.78,"AG.14361, PJ.34, AZD2461, niraparib",0.452225294612177,0.10790539730952,FALSE
+"metabolomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.43626,-1.18,0.232,1096,0.582,"pazopanib, motesanib, sorafenib, crenolanib, sunitinib, CP.673451, regorafenib, telatinib, ponatinib, dasatinib",0.6345120151091,0.235077015350112,FALSE
+"metabolomics","Pearson.est","phosphatase inhibitor",-0.3753,-0.993,0.444,1211,0.758,"alexidine, mycophenolic.acid, BVT.948",0.35261702988538,0.120330794367946,FALSE
+"metabolomics","Pearson.est","phosphodiesterase inhibitor",-0.33828,-0.895,0.535,1444,0.852,"YM.976",0.271646217978772,0.0695604052332999,FALSE
+"metabolomics","Pearson.est","PI3K inhibitor",-0.29869,-0.8,0.664,1358,0.862,"alpelisib, CH5132799, GDC.0980, PI3K.IN.2, TG100.115",0.177831920631982,0.0644927341752872,FALSE
+"metabolomics","Pearson.est","PLK inhibitor",0.55657,1.35,0.142,259,0.68,"HMN.214, NMS.1286937, GW.843682X",0.847711655616944,0.167491087293764,FALSE
+"metabolomics","Pearson.est","potassium channel blocker",-0.27809,-0.756,0.775,401,0.821,"ML133, meglitinide, dofetilide, oleoylethanolamide, ibutilide, mepivacaine",0.11069829749369,0.0856568428805592,FALSE
+"metabolomics","Pearson.est","PPAR receptor agonist",0.43598,1.05,0.419,560,0.771,"GW.501516, ciprofibrate, S26948",0.377785977033705,0.112945621949043,FALSE
+"metabolomics","Pearson.est","progesterone receptor agonist",0.49977,1.21,0.249,460,0.617,"tanaproget, norethindrone, danazol",0.603800652904264,0.209714835966758,FALSE
+"metabolomics","Pearson.est","proteasome inhibitor",0.25747,0.626,0.918,599,1,"MG.132, delanzomib, ixazomib.citrate, ixazomib",0.0371573187987575,0,FALSE
+"metabolomics","Pearson.est","protein synthesis inhibitor",0.47812,1.14,0.326,132,0.738,"puromycin, bruceantin, harringtonine, azomycin..2.nitroimidazole., cycloheximide, clofoctol",0.486782399932061,0.131943638176958,FALSE
+"metabolomics","Pearson.est","protein tyrosine kinase inhibitor",0.25261,0.618,0.897,111,1,"mubritinib",0.0472075569559079,0,FALSE
+"metabolomics","Pearson.est","RAF inhibitor",0.2862,0.702,0.825,471,1,"PLX.4720, CEP.32496, LGX818, vemurafenib",0.0835460514500749,0,FALSE
+"metabolomics","Pearson.est","RET tyrosine kinase inhibitor",-0.52342,-1.43,0.11,1119,0.442,"sorafenib, sunitinib, regorafenib, vandetanib",0.958607314841775,0.354577730650908,FALSE
+"metabolomics","Pearson.est","retinoid receptor agonist",-0.55345,-1.47,0.0967,1306,0.431,"AM.580, tamibarotene, fenretinide, adarotene",1.014573525917,0.365522729839268,FALSE
+"metabolomics","Pearson.est","ribonucleotide reductase inhibitor",-0.28892,-0.798,0.719,1333,0.836,"fludarabine, hydroxyurea",0.143271109617117,0.0777937225609836,FALSE
+"metabolomics","Pearson.est","serotonin receptor agonist",0.32517,0.809,0.699,336,1,"aripiprazole, ipsapirone",0.155522824254319,0,FALSE
+"metabolomics","Pearson.est","serotonin receptor antagonist",0.2685,0.657,0.881,587,1,"aripiprazole, lurasidone, pirenperone, ziprasidone, RS.16566, sertindole",0.0550240915879521,0,FALSE
+"metabolomics","Pearson.est","sodium channel blocker",0.49388,1.22,0.243,256,0.665,"benzocaine, benzethonium, mexiletine, A.803467, oxcarbazepine",0.614393726401688,0.177178354696895,FALSE
+"metabolomics","Pearson.est","src inhibitor",-0.47531,-1.31,0.169,1266,0.537,"PP.2, saracatinib, PP.1, dasatinib",0.772113295386326,0.270025714300444,FALSE
+"metabolomics","Pearson.est","sterol demethylase inhibitor",0.58447,1.41,0.117,431,0.641,"chlormidazole, posaconazole, sulconazole, lanoconazole",0.931814138253838,0.193141970481183,FALSE
+"metabolomics","Pearson.est","TGF beta receptor inhibitor",0.55805,1.33,0.156,4,0.674,"SB.525334",0.806875401645538,0.17134010346468,FALSE
+"metabolomics","Pearson.est","thymidylate synthase inhibitor",-0.22538,-0.604,0.934,325,0.925,"trifluridine, capecitabine, raltitrexed, carmofur, doxifluridine, ftorafur",0.0296531237699066,0.0338582672609674,FALSE
+"metabolomics","Pearson.est","topoisomerase inhibitor",0.23305,0.564,0.953,535,1,"TAS.103, voreloxin, amonafide, teniposide, mitoxantrone, valrubicin, dexrazoxane, etoposide, amsacrine, SN.38, camptothecin, etoposide.phosphate",0.0209070993616736,0,FALSE
+"metabolomics","Pearson.est","tubulin polymerization inhibitor",0.68532,1.65,0.0269,272,0.625,"ABT.751, epothilone.b, vincristine, flubendazole, dolastatin.10, indibulin, CYT.997, KX2.391, oxibendazole, parbendazole, plinabulin, nocodazole, mebendazole, taltobulin, vinorelbine, podophyllotoxin, combretastatin.A.4, verubulin",1.57024771999759,0.204119982655925,FALSE
+"metabolomics","Pearson.est","tyrosine kinase inhibitor",-0.30407,-0.813,0.675,1108,0.905,"AV.412, bafetinib, sorafenib, BMS.599626, aminopurvalanol.a, sunitinib, regorafenib, tivantinib, NVP.TAE226, dasatinib, vandetanib",0.170696227168975,0.0433514207947967,FALSE
+"metabolomics","Pearson.est","VEGFR inhibitor",-0.42573,-1.16,0.27,1096,0.582,"pazopanib, semaxanib, motesanib, sorafenib, golvatinib, sunitinib, BMS.690514, MK.2461, lucitanib, regorafenib, XL.647, AEE788, foretinib, telatinib, vandetanib",0.568636235841013,0.235077015350112,FALSE
+"metabolomics","Pearson.est","vitamin D receptor agonist",-0.61198,-1.61,0.0762,1208,0.519,"calcitriol, maxacalcitol, tacalcitol",1.1180450286604,0.284832642151542,FALSE
diff --git a/Examples/Fig3/DMEA/DMEA_venn_diagram.pdf b/Examples/Fig3/DMEA/DMEA_venn_diagram.pdf
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index 0000000..33fa497
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diff --git a/Examples/Fig3/GSEA/GSEA_correlation_matrix.pdf b/Examples/Fig3/GSEA/GSEA_correlation_matrix.pdf
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index 0000000..42d779c
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diff --git a/Examples/Fig3/GSEA/GSEA_dot_plot.pdf b/Examples/Fig3/GSEA/GSEA_dot_plot.pdf
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diff --git a/Examples/Fig3/GSEA/GSEA_interactive_network.graph.html b/Examples/Fig3/GSEA/GSEA_interactive_network.graph.html
new file mode 100644
index 0000000..0c9dd85
--- /dev/null
+++ b/Examples/Fig3/GSEA/GSEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-e128757e8a3cf048acd5" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/Fig3/GSEA/GSEA_mean_results.csv b/Examples/Fig3/GSEA/GSEA_mean_results.csv
new file mode 100644
index 0000000..0c2e6c2
--- /dev/null
+++ b/Examples/Fig3/GSEA/GSEA_mean_results.csv
@@ -0,0 +1,189 @@
+"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"KEGG_STEROID_BIOSYNTHESIS",1.9,0.169705627484771,0.000403602642045254,"transcriptomics, proteomics",2,0,"",0.0468844372052426
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",1.89,0.0565685424949237,NA,"transcriptomics, proteomics",2,0,"",NA
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",1.735,0.00707106781186548,0.00245538650670493,"transcriptomics, proteomics",2,0,"",0.109264699548369
+"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",1.65,0.014142135623731,0.00385509253353448,"transcriptomics, proteomics",2,0,"",0.114367745161523
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",1.645,0.0636396103067892,0.00344233335595883,"transcriptomics, proteomics",2,0,"",0.114367745161523
+"KEGG_SULFUR_METABOLISM",1.605,0.00707106781186548,0.00931186615149577,"transcriptomics, proteomics",2,0,"",0.207189021870781
+"KEGG_O_GLYCAN_BIOSYNTHESIS",1.565,0.205060966544099,0.0120534449875588,"transcriptomics, proteomics",2,0,"",0.238390356420608
+"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",1.425,0.332340187157677,0.0430064044702375,"transcriptomics, proteomics",2,0,"",0.425285555316793
+"KEGG_DORSO_VENTRAL_AXIS_FORMATION",1.405,0.190918830920368,0.0410846691086638,"transcriptomics, proteomics",2,0,"",0.425285555316793
+"KEGG_THYROID_CANCER",1.355,0.318198051533946,0.0544434400050243,"transcriptomics, proteomics",2,0,"",0.484546616044716
+"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",1.345,0.37476659402887,0.0745638809028388,"transcriptomics, proteomics",2,0,"",0.545777510978103
+"KEGG_PENTOSE_PHOSPHATE_PATHWAY",1.34,0.0989949493661166,0.0677131366593113,"transcriptomics, proteomics",2,0,"",0.545777510978103
+"KEGG_CIRCADIAN_RHYTHM_MAMMAL",1.335,0.176776695296637,0.0746072817526767,"transcriptomics, proteomics",2,0,"",0.545777510978103
+"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",1.325,0.148492424049175,0.0853738802461666,"transcriptomics, proteomics",2,0,"",0.545777510978103
+"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",1.31,0.226274169979695,0.0860320137928286,"transcriptomics, proteomics",2,0,"",0.545777510978103
+"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",1.31,0.127279220613579,0.092868801083374,"transcriptomics, proteomics",2,0,"",0.545777510978103
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+"KEGG_VEGF_SIGNALING_PATHWAY",1.3,0.29698484809835,0.0950511395523663,"transcriptomics, proteomics",2,0,"",0.545777510978103
+"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",1.27,0.0424264068711929,0.110726283843314,"transcriptomics, proteomics",2,0,"",0.545819606787798
+"KEGG_STARCH_AND_SUCROSE_METABOLISM",1.27,0.0424264068711929,0.105356424877823,"transcriptomics, proteomics",2,0,"",0.545819606787798
+"KEGG_TIGHT_JUNCTION",1.2605,0.409414826307011,0.124622555264086,"transcriptomics, proteomics",2,0,"",0.567541355057078
+"KEGG_GALACTOSE_METABOLISM",1.2515,0.379716341497176,0.0726700593454944,"transcriptomics, proteomics",2,0,"",0.545777510978103
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+"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",1.245,0.205060966544099,0.118780292633349,"transcriptomics, proteomics",2,0,"",0.556391897072001
+"KEGG_ETHER_LIPID_METABOLISM",1.235,0.162634559672906,0.145448350116678,"transcriptomics, proteomics",2,0,"",0.567541355057078
+"KEGG_BLADDER_CANCER",1.22,0.141421356237309,0.156190751615226,"transcriptomics, proteomics",2,0,"",0.567541355057078
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+"KEGG_PEROXISOME",1.083,0.207889393668845,0.281926936751494,"transcriptomics, proteomics",2,0,"",0.6716701443558
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+"KEGG_RIBOFLAVIN_METABOLISM",1.073,0.335168614282424,0.355964943177614,"transcriptomics, proteomics",2,0,"",0.73562531676609
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+"KEGG_NOTCH_SIGNALING_PATHWAY",1.053,0.13717871555019,0.359076184804547,"transcriptomics, proteomics",2,0,"",0.73562531676609
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+"KEGG_ENDOCYTOSIS",1.01,0.254558441227157,0.41471484859039,"transcriptomics, proteomics",2,0,"",0.77923639075272
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+"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.999,0.39739401102684,0.32740947400196,"transcriptomics, proteomics",2,0,"",0.723491477312518
+"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.997,0.089095454429505,0.494231402798328,"transcriptomics, proteomics",2,0,"",0.821152766307863
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+"KEGG_CHRONIC_MYELOID_LEUKEMIA",0.687,0.0268700576850888,0.985795352281177,"transcriptomics, proteomics",2,0,"",0.993830145373866
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+"KEGG_TYPE_I_DIABETES_MELLITUS",0.246,1.43401255224632,0.423559530760384,"transcriptomics, proteomics",2,0,"",0.785349963284879
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+"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.159,0.984292639411674,0.953937197099096,"transcriptomics, proteomics",2,0,"",0.984020887838418
+"KEGG_COLORECTAL_CANCER",0.1465,1.09106576337084,0.858270458071199,"transcriptomics, proteomics",2,0,"",0.97930859959406
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+"KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.0415,1.23814397385764,0.752420276507175,"transcriptomics, proteomics",2,0,"",0.943174712804769
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+"KEGG_MISMATCH_REPAIR",0.04,1.65462986797652,0.229563657308333,"transcriptomics, proteomics",2,0,"",0.6384739218888
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+"KEGG_LONG_TERM_DEPRESSION",0.013,0.958836795288958,0.991846643687544,"transcriptomics, proteomics",2,0,"",0.993830145373866
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+"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.004,0.878226622233692,0.993830145373866,"transcriptomics, proteomics",2,0,"",0.993830145373866
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+"KEGG_HISTIDINE_METABOLISM",-0.01,1.45663996924429,0.435979505093621,"transcriptomics, proteomics",2,0,"",0.790101003894316
+"KEGG_DILATED_CARDIOMYOPATHY",-0.0195,1.27491352647935,0.704284513092866,"transcriptomics, proteomics",2,0,"",0.93347324149777
+"KEGG_ALZHEIMERS_DISEASE",-0.0305,1.0458109293749,0.942695714699492,"transcriptomics, proteomics",2,0,"",0.984020887838418
+"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.0355,1.31168307910105,0.651915045777339,"transcriptomics, proteomics",2,0,"",0.905769265186157
+"KEGG_MAPK_SIGNALING_PATHWAY",-0.047,1.16248354827068,0.857286208793536,"transcriptomics, proteomics",2,0,"",0.97930859959406
+"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.05,1.72534054609518,0.172175467264507,"transcriptomics, proteomics",2,0,"",0.567541355057078
+"KEGG_PHENYLALANINE_METABOLISM",-0.06,1.75362481734264,0.15220013345769,"transcriptomics, proteomics",2,0,"",0.567541355057078
+"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.0725,1.35410948597224,0.591542877066933,"transcriptomics, proteomics",2,0,"",0.875787320142176
+"KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.0900000000000001,1.72534054609518,0.167465475964579,"transcriptomics, proteomics",2,0,"",0.567541355057078
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+"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.2115,1.27067088579223,0.610099032009156,"transcriptomics, proteomics",2,0,"",0.875787320142176
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+"KEGG_LINOLEIC_ACID_METABOLISM",-0.255,2.00111219075793,0.0515398080182186,"transcriptomics, proteomics",2,0,"",0.482846622486469
+"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.2835,1.67796439175568,0.171974288241125,"transcriptomics, proteomics",2,0,"",0.567541355057078
+"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.3195,1.52805775414413,0.304282229612415,"transcriptomics, proteomics",2,0,"",0.703405673649478
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+"KEGG_CELL_CYCLE",-0.405,1.29400540957138,0.34788644666131,"transcriptomics, proteomics",2,0,"",0.73562531676609
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+"KEGG_PRION_DISEASES",-0.5665,1.80100097168214,0.0905442126085091,"transcriptomics, proteomics",2,0,"",0.545777510978103
+"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.693,2.0605091603776,NA,"transcriptomics, proteomics",2,0,"",NA
+"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.6985,1.64260905269635,NA,"transcriptomics, proteomics",2,1,"transcriptomics",NA
+"KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.727,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_PYRIMIDINE_METABOLISM",-0.773,0.229102597104441,0.810501461709875,"transcriptomics, proteomics",2,0,"",0.968250068351394
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+"KEGG_BETA_ALANINE_METABOLISM",-0.8705,0.0346482322781409,0.741726507698968,"transcriptomics, proteomics",2,0,"",0.942659001159023
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+"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.966,0.246073159852918,0.487499805216055,"transcriptomics, proteomics",2,0,"",0.821152766307863
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+"KEGG_TGF_BETA_SIGNALING_PATHWAY",-1.019,0.354967604155647,0.411273569745188,"transcriptomics, proteomics",2,0,"",0.77923639075272
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+"KEGG_BASAL_TRANSCRIPTION_FACTORS",-1.27,0.0707106781186548,0.113393462978043,"transcriptomics, proteomics",2,0,"",0.545819606787798
+"KEGG_RNA_POLYMERASE",-1.28,0.0565685424949239,0.113456884557014,"transcriptomics, proteomics",2,0,"",0.545819606787798
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+"acyl carnitines",-1.41,NA,NA,"metabolomics",1,0,"",NA
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+"KEGG_AUTOIMMUNE_THYROID_DISEASE",-1.48,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-1.55,0.636396103067893,0.0378256367861026,"transcriptomics, proteomics",2,0,"",0.425285555316793
+"KEGG_ONE_CARBON_POOL_BY_FOLATE",-1.56,0.014142135623731,0.0233911092742783,"transcriptomics, proteomics",2,0,"",0.37623265403939
+"KEGG_LIMONENE_AND_PINENE_DEGRADATION",-1.74,0.325269119345812,0.00452156107133286,"transcriptomics, proteomics",2,0,"",0.114976838671036
+"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-1.82,0.014142135623731,0.00239320808077857,"transcriptomics, proteomics",2,1,"transcriptomics",0.109264699548369
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diff --git a/Examples/Fig3/GSEA/GSEA_results.csv b/Examples/Fig3/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..5ee06fe
--- /dev/null
+++ b/Examples/Fig3/GSEA/GSEA_results.csv
@@ -0,0 +1,370 @@
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+"transcriptomics","Log2FC","KEGG_ABC_TRANSPORTERS",0.23561,0.683,0.935,7191,0.996,"ABCA12, ABCB8, ABCB9, ABCA13, ABCD1, ABCC3, ABCA1, ABCA2, ABCB11, ABCC10, ABCD4, ABCA4, ABCC5, ABCA5, TAP2, ABCC11, ABCG1, ABCB6, ABCG2",0.0291883891274822,0.00174066157630127,FALSE
+"transcriptomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36169,1.04,0.384,5916,0.764,"PIK3R2, IKBKB, MAPK3, RPS6KB2, PML, RARA, PIK3CA, JUP, STAT5B, STAT3, BRAF, RELA, TCF7L1, RUNX1, BAD, PIM1, PIK3R3, CCNA1, STAT5A, MAPK1, PIK3R5, PIK3CB, CEBPA",0.415668775632469,0.11690664142431,FALSE
+"transcriptomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.36058,1.04,0.371,3562,0.764,"NECTIN1, CTNND1, CDH1, ERBB2, BAIAP2, NECTIN4, PTPN1, RAC2, MAPK3, INSR, PTPN6, SNAI2, MET, IGF1R, EP300, EGFR, PTPRF, TCF7L1, PTPRB, SRC",0.430626090384954,0.11690664142431,FALSE
+"transcriptomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.27558,0.808,0.762,5975,1,"TRADD, RXRA, CPT1B, PPARA, IKBKB, ACSL1, RXRB, CPT1C, ADIPOR1, IRS2, STAT3, PRKAA1, RELA, ACSL3, PRKAG2, PRKAB2, ACSL5, ACSL6, SLC2A1, MAPK10, IRS1, NFKBIA",0.1180450286604,0,FALSE
+"transcriptomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.44972,1.3,0.117,3496,0.803,"GLUL, AGXT, GLS2, ASL, ABAT, ASS1, GPT, NIT2, IL4I1",0.931814138253838,0.095284454721319,FALSE
+"transcriptomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.37286,1.08,0.321,5894,0.75,"PIK3R2, SCNN1A, MAPK3, INSR, PIK3CA, SFN, SCNN1G, IRS2, NEDD4L, PIK3R3, SCNN1B, HSD11B2, MAPK1, PIK3R5, IRS1, PIK3CB",0.493494967595128,0.1249387366083,FALSE
+"transcriptomics","Log2FC","KEGG_ALLOGRAFT_REJECTION",-0.23407,-0.835,0.759,16990,0.98,"PRF1, IL5",0.11975822410452,0.00877392430750515,FALSE
+"transcriptomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.40981,1.19,0.192,3971,0.704,"PLA2G12A, PLA2G6, PLA2G4B, PLA2G10, PLA2G4E, ACOX1, PLA2G2C",0.71669877129645,0.152427340857888,FALSE
+"transcriptomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",0.24418,0.709,0.907,6624,1,"NDUFV1, CAPN1, CACNA1D, GRIN1, ATP2A3, CALML3, COX5B, LRP1, ATP5F1E, NDUFB7, MAPK3, CDK5, FADD, NDUFS8, EIF2AK3, NDUFA3, NDUFV2, COX6C, UQCR10, GRIN2A, APH1A, COX6B2, GRIN2D, CHP1, PPP3CA, SDHD, ADAM10, BAD, UQCR11, GNAQ, NDUFB4, NDUFAB1, APOE, CALML6, UQCRB, BACE2, NDUFA6, UQCRHL, ITPR3, NDUFA5, UQCRC1, NDUFB5, BID, MAPK1, CACNA1F, UQCRFS1, UQCRC2, PLCB3, COX6A1, GSK3B, NDUFA2, SNCA, APP, ERN1, CAPN2, ATP5PD, GRIN2C, NOS1, CHP2",0.0423927129399047,0,FALSE
+"transcriptomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.55987,-2,0.0202,17343,0.292,"IARS2, MARS2, FARS2, FARSB, WARS2, RARS2, PSTK, YARS2",1.69464863055338,0.534617148551582,FALSE
+"transcriptomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51252,1.48,0.046,5085,0.531,"HK2, MPI, GMPPA, NANP, GCK, PGM1, GMPPB, NPL, NAGK, GALT, CYB5R1, NANS, FPGT, HK1, GALE, UXS1, CYB5R3, HEXB, GNPDA1, AMDHD2, PGM2",1.33724216831843,0.274905478918531,FALSE
+"transcriptomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28452,0.827,0.746,4515,0.993,"CAT, CCS, CASP1, MAPK13, GRIN1, GRIN2A, GPX1, GRIN2D, CHP1, MAPK11, PPP3CA, BAD, MAP3K5",0.127261172527331,0.00305075150461883,FALSE
+"transcriptomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26803,0.771,0.824,4719,1,"RFXANK, IFI30, TAPBP, CALR, CD74, CTSS, LGMN, CTSB, HSPA1B, B2M, CIITA, PDIA3, PSME1, CD4",0.0840727883028842,0,FALSE
+"transcriptomics","Log2FC","KEGG_APOPTOSIS",0.28433,0.815,0.76,6624,1,"TRADD, IL1RAP, CAPN1, PIK3R2, ENDOD1, IKBKB, PIK3CA, MYD88, FADD, TNFSF10, CASP10, RELA, CHP1, PPP3CA, IRAK4, BAD, ENDOG, PIK3R3, NGF, PRKACA, IL1A, BID, CSF2RB, BAX, PIK3R5, PIK3CB, IL1R1, NFKBIA, PRKAR1B, DFFA, CAPN2, BCL2L1, CHP2",0.119186407719209,0,FALSE
+"transcriptomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.38876,1.13,0.26,2694,0.706,"PLA2G12A, CYP4F3, CYP2E1, PTGES, PLA2G6, GGT7, PLA2G4B, LTC4S, PTGES2, EPHX2, CYP2J2, CYP4A22, PTGS1, PLA2G10, PLA2G4E, ALOX12B",0.585026652029182,0.151195298948196,FALSE
+"transcriptomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31866,0.924,0.581,5717,0.961,"GLUL, PYCR3, CKMT1A, CKMT1B, SAT2, NOS3, GLS2, ASL, ASS1, OAT, GATM, P4HA2, NAGS, PRODH, P4HA1, MAOA, AZIN2, ALDH4A1, GAMT",0.235823867609669,0.0172766123314547,FALSE
+"transcriptomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.3651,1.06,0.368,3482,0.757,"ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, JUP, DSP, ITGA3, CACNB2, DAG1, DSG2, ITGA2B, DSC2, TCF7L1, PKP2",0.434152181326482,0.120904120499927,FALSE
+"transcriptomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.50501,-1.81,0.0118,14596,0.146,"UGDH, MIOX, ALDH3A2, UGT2A1, ALDH1B1, ALDH7A1, ALDH9A1",1.92811799269387,0.835647144215563,TRUE
+"transcriptomics","Log2FC","KEGG_ASTHMA",-0.34369,-1.23,0.17,17122,0.467,"IL13, EPX, IL5",0.769551078621726,0.330683119433888,FALSE
+"transcriptomics","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.42092,-1.48,0.0396,16806,0.293,"IFNA21, PRF1, IFNA13, IL5, CTLA4",1.40230481407449,0.533132379645891,FALSE
+"transcriptomics","Log2FC","KEGG_AXON_GUIDANCE",0.44776,1.29,0.124,5666,0.805,"EPHA1, PAK6, PLXNB2, EPHB3, PLXNB1, PLXNA3, SEMA4A, EFNA1, FES, SEMA3E, EFNA4, SEMA4B, RAC2, LIMK2, SEMA7A, EFNA3, SRGAP3, MAPK3, NTN4, RHOD, UNC5B, NTN1, PLXNB3, CDK5, EPHB4, MET, PLXNA2, EPHB6, SEMA3B, ABLIM3, NCK2, EPHB2, SEMA4F, SRGAP1, UNC5A, ABLIM2, EFNB3, EFNB1, ABLIM1, SEMA5B, CHP1, PPP3CA, PAK2, SEMA4C, SEMA4D, NGEF, SEMA3C, LIMK1, NCK1, SEMA5A, RASA1, RND1, ROBO3, RAC1, PAK1, PAK4, MAPK1, NFATC1",0.906578314837765,0.0942041196321315,FALSE
+"transcriptomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.3741,1.08,0.318,4115,0.75,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, WNT4, DVL3, BMP2, WNT10A, GLI3, TCF7L1, FZD4, DVL2, WNT11",0.497572880015567,0.1249387366083,FALSE
+"transcriptomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36638,-1.32,0.112,18395,0.384,"TBPL1, TAF9B, TBP, GTF2H2, TAF9, TAF1L",0.950781977329818,0.415668775632469,FALSE
+"transcriptomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",0.30931,0.89,0.646,912,0.974,"SMUG1, POLD4, POLB",0.189767482004916,0.0114410431213845,FALSE
+"transcriptomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.24897,-0.895,0.577,17472,0.879,"ALDH1B1, ALDH7A1, SMS, ALDH9A1",0.238824186844269,0.0560111249262281,FALSE
+"transcriptomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.30636,0.885,0.645,3986,0.967,"ACOT4, TECR, ACAA1, ELOVL6, ACOX1, SCD5",0.190440285364732,0.0145735259169983,FALSE
+"transcriptomics","Log2FC","KEGG_BLADDER_CANCER",0.38783,1.12,0.262,4516,0.711,"CDH1, ERBB2, MMP9, TYMP, VEGFB, MAPK3, EGFR, E2F1, DAPK1, THBS1, FGFR3, BRAF, PGF, VEGFA, DAPK2",0.581698708680255,0.148130399270234,FALSE
+"transcriptomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.28276,0.829,0.754,2472,1,"ABAT, HMGCL, BDH1, HMGCS1, ACADS, EHHADH",0.122628654130226,0,FALSE
+"transcriptomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39615,1.15,0.241,6959,0.71,"VAV1, BLNK, PIK3R2, PLCG2, DAPP1, RAC2, VAV3, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, IFITM1, CD72, CD79A, RELA, CD19, CHP1, PPP3CA, LYN, PIK3R3, RAC1, MAPK1, NFATC1, PIK3R5, PIK3AP1, PIK3CB, NFKBIA, GSK3B, FOS, SYK, NFATC4, GRB2, CHP2, INPP5D, BCL10, CD22",0.617982957425132,0.148741651280925,FALSE
+"transcriptomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.29926,0.872,0.691,4406,0.982,"DRD5, PTAFR, BDKRB2, ERBB2, P2RX4, PLCG2, GNA15, CACNA1D, ERBB3, GRIN1, PLCD1, ATP2A3, CALML3, NOS3, CAMK2G, ADORA2B, ADORA2A, CACNA1I, ADCY4, BDKRB1, RYR1, PTK2B, EGFR, ATP2B4, SLC8A2, GRIN2A, PLCG1, SPHK2, PHKG1, ADRB2, GRIN2D, CHP1, P2RX6, PPP3CA, EDNRA, TNNC1, GNAS, GNAQ, P2RX2, LTB4R2, HTR7",0.160521952625802,0.00788851221305034,FALSE
+"transcriptomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27818,0.802,0.78,6162,1,"TNNI3, CACNA1D, CACNG1, COX5B, CACNB3, CACNG4, CACNB2, COX6C, UQCR10, COX6B2, TNNT2, TNNC1, SLC9A1, UQCR11, UQCRB, UQCRHL, UQCRC1, CACNA1F, UQCRFS1, UQCRC2, COX6A1",0.10790539730952,0,FALSE
+"transcriptomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.37321,1.08,0.349,3535,0.75,"CDH3, NECTIN1, CDH1, CLDN8, ITGB2, CLDN9, CLDN7, CLDN4, F11R, ITGB8, CDH5, SDC1, ICOSLG, SDC4, CLDN18, ICAM3, CD6, GLG1, CLDN11, CD40, SELL, PTPRF, CLDN23, CD276, CLDN3",0.45717457304082,0.1249387366083,FALSE
+"transcriptomics","Log2FC","KEGG_CELL_CYCLE",-0.36349,-1.32,0.108,15880,0.384,"ORC1, MCM4, PTTG2, CCNA2, ORC6, SMAD4, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, MCM3, ANAPC10, CDK6, CDC20, CDK1, SMC1A, CCNH, CCNB3, CDKN2C, CDC25A, TGFB1, ORC4, CCNB1, MCM6, PRKDC, TTK, CDC14A, CDKN2B, E2F2, BUB3, ORC2, CDC7, PTTG1, YWHAQ, HDAC2, SMC3, E2F5, ORC3, CDKN2A, E2F3, SMAD2, ANAPC13",0.96657624451305,0.415668775632469,FALSE
+"transcriptomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.31904,0.917,0.585,4742,0.971,"CCR3, PRKCD, CCL22, STAT2, GRK7, VAV1, PIK3R2, FOXO3, GRK2, CX3CL1, RAC2, VAV3, CCL17, JAK3, CXCL10, IKBKB, MAPK3, CCL28, CCR2, ARRB1, VAV2, CCR7, ADCY5, PIK3CA, ADCY4, CXCL11, CXCL16, CCL5, PTK2B, STAT5B, RAP1A, CXCL9, CXCR2, STAT3, BRAF, ADCY6, RELA, TIAM1, PXN, GNB2, TIAM2, CCL26, CCL19, CXCL3, PRKCZ, CXCR6, WASL, LYN, PIK3R3, STAT1, CCR1",0.23284413391782,0.0127807700919951,FALSE
+"transcriptomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.24297,0.706,0.907,6797,0.988,"CBLC, BCR, PIK3R2, IKBKB, MAPK3, PIK3CA, STAT5B, E2F1, CBLB, BRAF, CDKN1B, RELA, MECOM, RUNX1, BAD, PIK3R3, TGFB3, CRKL, STAT5A, TGFBR2, MAPK1, PIK3R5, PIK3CB, NFKBIA, CDKN1A, BCL2L1, GRB2, CTBP1, CCND1",0.0423927129399047,0.00524305541237188,FALSE
+"transcriptomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.41491,1.21,0.174,4027,0.689,"BHLHE41, NR1D1, CSNK1E, BHLHE40, PER3",0.7594507517174,0.161780778092374,FALSE
+"transcriptomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29489,0.855,0.718,7287,0.994,"PC, IDH2, ACO2, IDH3B, SDHD, OGDHL, MDH1, MDH2, OGDH, IDH3G, IDH1, SUCLG2, SDHA",0.1438755557577,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_COLORECTAL_CANCER",-0.17873,-0.625,0.991,14592,1,"KRAS, RAF1, LEF1, CASP9, BIRC5, AKT2, MAPK9, BCL2, MSH6, CASP3, MSH3, RHOA, APPL1, APC2, AKT3, SMAD4, PIK3R1, PIK3CG, MSH2, APC, TGFB1, TCF7, MAPK8, AXIN2, SMAD2",0.00392634551472468,0,FALSE
+"transcriptomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.26321,0.763,0.867,6969,0.992,"BDKRB2, F3, BDKRB1, VWF, FGA, FGG, CFB, PROC, C3, PLAU, CD59, SERPINA5, C2, PLAT, SERPINA1, C9, C1R, CFI, F8, CD55, C4A, SERPINF2, F12, FGB",0.0619809025237897,0.00348832784582135,FALSE
+"transcriptomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.22246,-0.792,0.741,15262,1,"BHMT, ADI1, MTR, CDO1, GOT2, SRM, LDHB, MAT2A, AMD1, SMS, MTAP, TRDMT1",0.130181792020672,0,FALSE
+"transcriptomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33412,0.969,0.504,5572,0.868,"CCR3, IFNL3, IFNL1, CSF1R, CCL22, TNFSF13, IFNL2, IL1RAP, CRLF2, TNFRSF21, PDGFA, IL9R, BMP7, CX3CL1, TNFRSF18, CCL17, IL4R, VEGFB, CXCL10, LTBR, CCL28, CCR2, IFNLR1, EPOR, IFNB1, PDGFB, BMP2, CCR7, FLT3LG, MET, CXCL11, CXCL16, CCL5, TNFRSF25, EGFR, CTF1, ACVR1B, IL18, CD40, IL12B, CXCL9, TNFSF10, CXCR2, TNFRSF14, CLCF1, IL7R, EPO, CCL26, IL20RB, IL6R, IL6, NGFR, CCL19, CXCL3, IL20RA, TNFSF18, CXCR6, VEGFA, CSF2, TNFRSF12A, IL15RA, CCR1, LTB, IL12A, IL1R2, PRLR, TGFB3, CSF1, GH2, OSMR, INHBB, IL1A, VEGFC, EDAR, IFNGR1, TGFBR2, CXCL6, IL17RA, CSF2RB",0.297569463554475,0.0614802748235081,FALSE
+"transcriptomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.36654,1.06,0.345,3908,0.757,"CASP1, MAVS, RIPK3, IRF3, CXCL10, IKBKB, IFNB1, CCL5, DDX58, IL18, PYCARD, RELA, IKBKE, IL6",0.462180904926726,0.120904120499927,FALSE
+"transcriptomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.30112,0.882,0.67,4386,0.966,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ADCY5, ADCY4, ITGA3, CACNB2, DAG1, ITGA2B, ADCY6, TNNT2, TNNC1, GNAS, ITGA2",0.173925197299174,0.0150228735845067,FALSE
+"transcriptomics","Log2FC","KEGG_DNA_REPLICATION",-0.44719,-1.56,0.037,15778,0.326,"DNA2, RFC2, MCM4, RFC5, MCM3, RNASEH1, PRIM1, MCM6, RNASEH2B, PRIM2, POLE3, RFC1, RPA2, POLA1",1.431798275933,0.486782399932061,FALSE
+"transcriptomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.4409,1.27,0.124,5751,0.753,"ETV7, ETS2, MAPK3, ETV6, EGFR, NOTCH3, PIWIL2, NOTCH1, MAPK1, SPIRE1, SPIRE2",0.906578314837765,0.123205023799299,FALSE
+"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47037,1.36,0.0989,3662,0.73,"ADH7, ALDH3B2, GSTK1, CYP2E1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, FMO4, MGST2, CYP2D6, UGT2B17, MGST3",1.00480370840282,0.136677139879544,FALSE
+"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.40437,1.17,0.243,3623,0.721,"XDH, TYMP, NAT1, UCKL1, CES2, UPP1, TK1, CDA, UGT2B17, TPMT, GUSB, ITPA",0.614393726401688,0.142064735280571,FALSE
+"transcriptomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.39479,1.15,0.222,4629,0.71,"CHAD, LAMA3, ITGB6, LAMB3, ITGB8, SDC1, SDC4, CD47, TNC, LAMC2, GP6, ITGB4, CD44, AGRN, THBS3, VWF, ITGA3, DAG1, THBS1, ITGA2B, COL1A1, LAMA5, LAMB1, ITGA2, COL5A1, HSPG2",0.653647025549361,0.148741651280925,FALSE
+"transcriptomics","Log2FC","KEGG_ENDOCYTOSIS",0.41396,1.19,0.207,5701,0.704,"EPN3, CHMP4B, CBLC, PSD4, CSF1R, ITCH, TRAF6, RAB11FIP4, CHMP2B, GRK7, FGFR2, RAB22A, PLD1, ARFGAP1, CHMP2A, GRK2, RAB5B, ARAP1, ERBB3, TFRC, ACAP1, EHD2, PLD2, SMURF1, VPS37C, ARRB1, CHMP5, PRKCI, CHMP3, RAB11FIP1, MET, MVB12A, SH3GLB2, IGF1R, CHMP6, VPS28, ARAP2, PARD6B, EGFR, EPN1, ARFGAP3, VPS37B, FGFR3, LDLRAP1, CXCR2, ARFGAP2, CBLB, EPS15, AP2M1, ADRB2, SRC, HSPA1B, CHMP4C, RAB11FIP5, AGAP1, ACAP2, PRKCZ, AP2A1, NEDD4L, ARAP3, PIP5K1C, STAMBP, CHMP1B, LDLR, ASAP2, HSPA2, IQSEC1, DNM2, RAB11B, RAB31, ARF6, RAB5C, VPS25, STAM2",0.684029654543082,0.152427340857888,FALSE
+"transcriptomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.26466,0.768,0.838,3392,1,"CDH1, ERBB2, PIK3R2, FOXO3, MAPK3, PIK3CA, EGFR, BRAF, TCF7L1",0.0767559813697235,0,FALSE
+"transcriptomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.38362,1.1,0.284,6354,0.735,"MAPK13, PLCG2, F11R, ATP6V1C2, ATP6V0D2, ATP6V1B1, ATP6V1F, IKBKB, MET, CCL5, EGFR, ATP6AP1, CXCR2, PLCG1, RELA, SRC, MAPK11, NOD1, ADAM10, TCIRG1, LYN, ATP6V1G1, ATP6V0A4, RAC1, PAK1, MAPK10, ATP6V1C1, NFKBIA, TJP1, ATP6V1E1, IGSF5",0.546681659952962,0.133712660915805,FALSE
+"transcriptomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.39525,1.14,0.249,5894,0.714,"GAB1, PAK6, CBLC, ERBB2, PIK3R2, PLCG2, ERBB3, CAMK2G, MAPK3, RPS6KB2, PIK3CA, NCK2, EGFR, STAT5B, BTC, CBLB, BRAF, PLCG1, CDKN1B, SRC, TGFA, PAK2, AREG, BAD, PIK3R3, NCK1, CRKL, STAT5A, PAK1, PAK4, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB",0.603800652904264,0.146301788223826,FALSE
+"transcriptomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.38786,1.12,0.268,3971,0.711,"PLA2G12A, PLD1, PLA2G6, PLA2G4B, PLD2, LPCAT2, PLA2G10, PLA2G4E, PLPP3, LPCAT4, PLA2G2C",0.571865205971211,0.148130399270234,FALSE
+"transcriptomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38078,1.11,0.277,3627,0.717,"ADH7, ACAA1, CPT1B, GCDH, CYP4A22, ACSL1, CPT2, CPT1C, ACADS, EHHADH, ACOX1, ACSL3",0.557520230935551,0.1444808443322,FALSE
+"transcriptomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.33886,0.98,0.475,2596,0.866,"PRKCD, PLA2G12A, VAV1, MAPK13, PIK3R2, PLCG2, RAC2, VAV3, PLA2G6, PLA2G4B, MAPK3, VAV2, PIK3CA, PLA2G10, PLA2G4E",0.323306390375133,0.0624821079826534,FALSE
+"transcriptomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.40295,1.18,0.204,5894,0.703,"PRKCD, VAV1, PLD1, PIK3R2, PLCG2, RAC2, VAV3, LIMK2, PLA2G6, PLA2G4B, PLA2G4F, PLD2, MAPK3, RPS6KB2, VAV2, MARCKS, GSN, PIK3CA, PLA2G4E, PLCG1, PLPP3, SPHK2, WASL, LYN, PIK3R3, PIP5K1C, SPHK1, LIMK1, CRKL, SCIN, ASAP2, MYO10, DNM2, RAC1, PAK1, ARF6, MAPK1, PIK3R5, PIK3CB",0.690369832574101,0.153044674980176,FALSE
+"transcriptomics","Log2FC","KEGG_FOCAL_ADHESION",0.30588,0.886,0.635,6359,0.975,"PAK6, CHAD, ERBB2, LAMA3, VAV1, ITGB6, PDGFA, PIK3R2, LAMB3, ITGB8, RAC2, VAV3, VEGFB, TNC, LAMC2, ITGB4, MAPK3, PPP1CA, VAV2, PDGFB, PIK3CA, PPP1CB, MET, IGF1R, THBS3, VWF, PDGFD, ITGA3, EGFR, RAP1A, THBS1, ITGA2B, BRAF, CAV2, PXN, COL1A1, SRC, CAV1, MYL9, ARHGAP35, PAK2, LAMA5, BAD, PGF, LAMB1, ITGA2, COL5A1, VEGFA, RASGRF1, PIK3R3, PIP5K1C, CRKL, MYL7, ARHGAP5, VEGFC, RAC1, PAK1, BCAR1, PAK4, MAPK1, MAPK10, PIK3R5, PIK3CB, PTEN, COL1A2, ITGA5, TLN2, GSK3B, COL6A1, DIAPH1, ITGA4, CAPN2",0.197226274708024,0.0109953843014632,FALSE
+"transcriptomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.42522,1.24,0.17,5764,0.758,"ALPP, QDPR, SPR, FPGS",0.769551078621726,0.120330794367946,FALSE
+"transcriptomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5816,1.66,0.0143,3752,0.308,"ALDOC, PFKFB2, HK2, MPI, GMPPA, FBP1, GMPPB, PFKL, FBP2, MTMR1, FPGT, HK1, PFKFB4, ALDOA",1.84466396253494,0.511449283499556,FALSE
+"transcriptomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.52612,1.52,0.0332,3636,0.508,"HK2, GCK, GAA, PGM1, PFKL, B4GALT1, GALT, GANC, HK1, B4GALT2, GLB1, GALE",1.47886191629596,0.294136287716081,FALSE
+"transcriptomics","Log2FC","KEGG_GAP_JUNCTION",-0.17017,-0.584,0.981,15556,0.991,"ADRB1, TUBB3, ITPR2, MAP2K5, ADCY7, PRKX, TUBA1B, TUBB, GNAI1, ITPR1, TUBAL3, PRKACB, CDK1, PLCB4, PDGFRA, TUBA1A, NRAS, TUBB4A, TUBB2B, TUBB2A",0.0083309926200515,0.00392634551472468,FALSE
+"transcriptomics","Log2FC","KEGG_GLIOMA",0.26293,0.768,0.824,3686,1,"PDGFA, PIK3R2, PLCG2, CALML3, CAMK2G, MAPK3, PDGFB, PIK3CA, IGF1R, EGFR, E2F1, BRAF, PLCG1, TGFA",0.0840727883028842,0,FALSE
+"transcriptomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.33643,0.966,0.511,4600,0.867,"GSTK1, GGT7, GSTT2, GSTO2, GSS, IDH2, GSTZ1, GSTA3, OPLAH, MGST2, GGT6, GPX1, MGST3, ANPEP, G6PD, GPX3",0.291579099865287,0.0619809025237897,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.17981,0.523,0.997,5968,0.996,"DGKA, LIPG, DGAT1, MGLL, TKFC, PLPP3, CEL, DGKH, AGPAT2, PNPLA3, DGKI, AWAT2, MBOAT1, DGKE",0.00130484168834428,0.00174066157630127,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.36747,1.06,0.355,5053,0.757,"PISD, CDS1, PLA2G12A, CHKB, DGKA, PLD1, PLA2G6, PLA2G4B, PLD2, PCYT2, CHKA, LPCAT2, ETNK2, CDS2, PLA2G10, PLA2G4E, PLPP3, MBOAT7, LPCAT4, PLA2G2C, DGKH, AGPAT2, PGS1, LPCAT3, LYPLA2, ACHE, PCYT1A, DGKI",0.449771646944906,0.120904120499927,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31093,0.908,0.606,6983,0.965,"AGXT, GCAT, AOC2, GATM, SARDH, SHMT1, MAOA, AMT, GAMT, CTH, SDS, GNMT, AOC3, ALAS2, SRR",0.217527375833714,0.0154726866562074,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.4334,1.24,0.153,1880,0.758,"LDHC, ADH7, ACSS2, ALDH3B2, ALDOC, HK2, ALDH1A3, GCK, ALDH3B1, FBP1, PGM1, GALM, PFKL",0.815308569182401,0.120330794367946,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.43624,1.27,0.141,4160,0.753,"B4GALT7, CHPF, CHST12, XYLT2, CHST14, XYLT1, CHPF2, CHST11, CHST15",0.85078088734462,0.123205023799299,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.45434,1.32,0.103,3529,0.849,"B4GALT7, EXT1, HS3ST1, XYLT2, HS6ST1, NDST1, HS6ST2, XYLT1",0.987162775294828,0.0710923097560473,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66703,1.93,0,3600,0.287,"B3GNT7, CHST6, B4GALT4, B4GALT1, B3GNT2, CHST4, ST3GAL1, B4GALT2",Inf,0.542118103266008,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.5591,1.62,0.0235,4196,0.347,"HGSNAT, NAGLU, HPSE, HYAL4, IDS, GALNS, HYAL2, GUSB, GLB1, HEXB",1.62893213772826,0.459670525209126,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.42593,1.23,0.161,6306,0.722,"ST6GALNAC5, B3GALT4, SLC33A1, ST3GAL1, GLB1, HEXB, ST6GALNAC6, ST6GALNAC4, HEXA, ST8SIA1",0.79317412396815,0.141462802430361,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.58271,1.69,0.00992,4276,0.351,"FUT2, FUT1, NAGA, B3GALNT1, ST3GAL1, GBGT1, A4GALT, HEXB, B3GALT5",2.00348832784582,0.454692883534176,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.59777,1.73,0.0122,3600,0.331,"B3GNT3, ABO, FUT3, FUT2, B4GALT4, B3GNT5, B3GNT4, B4GALT1, FUT1, B3GNT2, ST3GAL4, B4GALT2",1.91364016932525,0.480172006224281,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50004,1.43,0.0601,3611,0.648,"PIGT, PIGU, GPAA1, PIGZ, PIGV, PIGQ, PIGL, PIGX, PIGS",1.22112552799726,0.188424994129407,FALSE
+"transcriptomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.50461,-1.86,0,16224,0.142,"HYI, MTHFD2L, MTHFD2, ACO1, CS, MTHFD1L, HAO2",Inf,0.847711655616944,TRUE
+"transcriptomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34964,1.01,0.437,2596,0.816,"PRKCD, PLA2G12A, MAPK13, PLD1, CACNA1D, PLA2G6, CALML3, PLA2G4B, MAP3K4, PLD2, CAMK2G, MAPK3, MAP3K1, ADCY5, CGA, ADCY4, MMP14, PTK2B, PLA2G10, EGFR, PLA2G4E",0.359518563029578,0.0883098412461389,FALSE
+"transcriptomics","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.20626,-0.727,0.913,3907,1,"IL6, IL1A, KLRC1, KIR2DL1, IL1B, KIR2DL3, KIR3DL2, CD86, FAS, CD80, IFNG, CD28, TNF, KLRD1, GZMB, FASLG, IL2, PRF1",0.039529222465701,0,FALSE
+"transcriptomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36379,1.05,0.365,2621,0.765,"WNT3A, WNT9A, WNT7B, BMP7, WNT7A, WNT4, BMP2, CSNK1E, WNT10A, CSNK1A1, GLI3",0.437707135543525,0.116338564846382,FALSE
+"transcriptomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.38485,1.11,0.278,6109,0.717,"CSF1R, IL9R, IL4R, TFRC, EPOR, FLT3LG, CD44, ITGA3, CD9, ITGA2B, CD19, IL7R, EPO, IL6R, IL6, ANPEP, CD59, ITGA2, CSF2, CD4, IL1R2, CSF1, IL1A, IL1R1, CD1D, CD55, ITGA5",0.555955204081924,0.1444808443322,FALSE
+"transcriptomics","Log2FC","KEGG_HISTIDINE_METABOLISM",0.35152,1.02,0.413,1584,0.795,"ALDH3B2, HEMK1, HAL, ALDH1A3, ALDH3B1",0.384049948343599,0.0996328713435297,FALSE
+"transcriptomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.23381,0.681,0.93,764,0.991,"POLD4, SEM1",0.0315170514460649,0.00392634551472468,FALSE
+"transcriptomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.17121,-0.598,1,16664,1,"ITPR1, NDUFS4, BBC3, AP2S1, SOD1, COX6B1, COX7A2, DCTN4, AP2A2, PLCB4, ATP5F1C, NDUFA9, VDAC2, POLR2E, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, HDAC2, HIP1, TBPL1, TBP, UCP1, ATP5F1A, POLR2D, BDNF, NDUFS5, TFAM, GRIN2B",0,0,FALSE
+"transcriptomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30969,0.892,0.644,4437,0.978,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ITGA3, CACNB2, DAG1, ITGA2B, PRKAA1, ACE, TNNT2, IL6, TNNC1, ITGA2, PRKAG2",0.191114132640188,0.00966114521239857,FALSE
+"transcriptomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30094,0.87,0.675,6116,0.977,"PLCG2, INPP4B, PLCD1, INPP4A, ALDH6A1, PIK3CA, PIP4K2C, PLCG1, PIK3C2G, PIK3C2B, INPP5K, IMPA2, PIP5K1C, INPPL1, INPP5J, ISYNA1, PIK3CB, PTEN, PLCB3, IPMK",0.170696227168975,0.0101054362812269,FALSE
+"transcriptomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.32542,0.943,0.545,6911,0.915,"CBLC, PPP1R3D, HK2, PTPN1, PIK3R2, GYS1, CALML3, SOCS1, MKNK1, GCK, IKBKB, MAPK3, RPS6KB2, FBP1, INSR, PPP1CA, SH2B2, PIK3CA, PPP1CB, PRKCI, TSC1, FBP2, IRS2, PTPRF, CBLB, BRAF, PRKAA1, PHKG1, HK1, FOXO1, PRKCZ, BAD, PRKAG2, INPP5K, EXOC7, PIK3R3, FASN, PYGL, CALML6, CRKL, PRKAB2, PRKACA, RHEB, PPP1R3B, MAPK1, FLOT2, MAPK10, PIK3R5, IRS1, PIK3CB, PRKAR1B, GSK3B, PHKG2, TRIP10, GRB2, INPP5D, PYGB, PRKAG1, TSC2, RPTOR",0.263603497723358,0.0385789059335517,FALSE
+"transcriptomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.3125,0.903,0.612,3908,0.958,"TNFSF13, ICOSLG, LTBR, CCL28, CD40, PIGR, IL6",0.213248577854439,0.0186344909214556,FALSE
+"transcriptomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.33678,0.975,0.51,5894,0.87,"IFNL3, IFNL1, CBLC, STAT2, IFNL2, CRLF2, PIK3R2, IL9R, IRF9, JAK3, IL4R, SOCS1, CISH, IFNLR1, EPOR, PTPN6, IFNB1, PIK3CA, TYK2, EP300, STAT6, CTF1, STAT5B, IL12B, CBLB, STAT3, CLCF1, IL7R, EPO, IL20RB, IL6R, IL6, PIAS3, IL20RA, PIM1, CSF2, PIK3R3, SPRY1, IL15RA, STAT1, IL12A, PRLR, GH2, STAT5A, OSMR, IFNGR1, JAK1, CSF2RB, STAM2, PIK3R5, PIK3CB",0.292429823902064,0.0604807473813815,FALSE
+"transcriptomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.42556,1.23,0.172,6358,0.722,"TRAF6, ITGB2, NCF4, MAPK13, MAPK3, PTPN6, MYD88, IL12B, TAB1, RELA, MAPK11, C3, TLR2, IRAK4, STAT1, IL12A, TGFB3, IL1A, IFNGR1, JAK1, TAB2, MAPK1, NFKBIA, FOS, ITGA4",0.764471553092451,0.141462802430361,FALSE
+"transcriptomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.41873,1.22,0.171,3793,0.694,"CTNND1, CLDN8, ITGB2, MMP9, CLDN9, VAV1, NCF4, CLDN7, MAPK13, PIK3R2, PLCG2, CLDN4, F11R, CDH5, RAC2, VAV3, VAV2, CLDN18, PIK3CA, RASSF5, PTK2B, RAP1A, CLDN11, RAPGEF3, PLCG1, SIPA1, PXN, CLDN23, CLDN3, MYL9, MAPK11, ARHGAP35",0.767003889607846,0.158640529545145,FALSE
+"transcriptomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.42081,-1.51,0.07,15341,0.292,"ALDH3A2, HADHA, YOD1, ALDH1B1, ALDH7A1, ALDH9A1",1.15490195998574,0.534617148551582,FALSE
+"transcriptomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.40266,1.16,0.214,2596,0.723,"PLA2G12A, CYP2E1, PLA2G6, PLA2G4B, CYP2J2, PLA2G10, PLA2G4E",0.669586226650809,0.140861702705469,FALSE
+"transcriptomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.24312,0.691,0.925,6599,0.996,"PLA2G12A, GNAO1, PLA2G6, PLA2G4B, MAPK3, IGF1R, RYR1, PLA2G10, PLA2G4E, BRAF, PLA2G2C, GNAS, GNAQ, LYN, ITPR3, MAPK1, PLCB3, PPP2R1A, GUCY1A1, NOS1, PLA2G2F, GUCY1B1, GNA12",0.0338582672609674,0.00174066157630127,FALSE
+"transcriptomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23447,0.675,0.931,5774,0.989,"GRIN1, CALML3, CAMK2G, MAPK3, PPP1CA, PPP1CB, EP300, RAP1A, RAPGEF3, GRIN2A, BRAF, GRIN2D, CHP1, PPP3CA, GNAQ, RPS6KA2, CALML6, ITPR3, PRKACA, MAPK1, RPS6KA1",0.0310503190186574,0.0048037084028206,FALSE
+"transcriptomics","Log2FC","KEGG_LYSINE_DEGRADATION",0.22598,0.649,0.95,2472,0.994,"BBOX1, KMT5B, KMT5C, GCDH, AASDH, EHHADH",0.0222763947111523,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_LYSOSOME",0.52683,1.51,0.0375,5277,0.488,"CTSH, GM2A, CTSA, CTSV, HGSNAT, SLC11A1, NAGLU, GGA2, CTSD, ARSA, ATP6V0D2, LIPA, DNASE2, ABCB9, SUMF1, GAA, MANBA, NPC1, NAGA, ACP5, PSAP, IDS, GNPTG, NPC2, AP1M2, GALNS, CTSS, LAPTM4A, NAPSA, AP1B1, AP3M2, GGA1, LGMN, NEU1, TPP1, ATP6AP1, PSAPL1, ASAH1, LAMP3, CD68, CTSB, LAMP1, CLN5, GUSB, GLB1, GGA3, AP3S2, LAMP2, FUCA1, NAGPA, SCARB2, CTSE, HEXB, PPT1, AP1S1, TCIRG1, MAN2B1, CD63, SLC11A2, MFSD8, ABCA2, CTSZ, SORT1, AP1S3, ATP6V0A4, ENTPD4, GBA",1.42596873227228,0.311580177997289,FALSE
+"transcriptomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.26798,0.775,0.836,5856,1,"NTF4, PLA2G12A, TRAF6, FGF11, FGFR2, MAPK13, PDGFA, CACNA1D, RAC2, CACNG1, PLA2G6, PLA2G4B, MAP3K4, MKNK1, DUSP9, CACNB3, HSPB1, CACNG4, IKBKB, MAPK3, ARRB1, MAP4K1, MAP3K1, PDGFB, CACNA1I, FGF1, DUSP3, MAPK8IP2, MAX, NTRK2, PLA2G10, EGFR, CACNB2, PLA2G4E, MAP3K11, MAPKAPK3, RAP1A, JUND, ECSIT, MAP3K6, TAB1, LAMTOR3, FGFR3, MAP3K13, TAOK3, BRAF, DUSP10, RELA, STK3, DUSP14, CHP1, HSPA1B, MAPK11, PPP3CA, PAK2, PLA2G2C, MECOM, MAP3K8, GADD45B, RASGRF1, FGF12, MAP4K2, MAP3K5, RPS6KA2, IL1R2, RASA1, RPS6KA4, MAPKAPK2, NF1, STK4, TGFB3, CRKL, PPM1A, HSPA2, NGF, PRKACA, IL1A, RAC1, PAK1, MAP4K3, TGFBR2, RRAS, TAB2, MAPK1, DUSP8, MAP2K7, NLK, GADD45A, RPS6KA1, MAPK10, MAPK8IP3, CACNA1F",0.0777937225609836,0,FALSE
+"transcriptomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26478,0.764,0.846,1432,0.999,"HES1, GCK",0.0726296369609765,0.000434511774017692,FALSE
+"transcriptomics","Log2FC","KEGG_MELANOGENESIS",0.36219,1.06,0.354,6175,0.757,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, GNAO1, CALML3, WNT4, DVL3, CAMK2G, MAPK3, ADCY5, WNT10A, ADCY4, EP300, ADCY6, TCF7L1, FZD4, CREB3L4, DVL2, WNT11, GNAS, GNAQ, CALML6, CREB3L3, MITF, PRKACA, ASIP, CREB3L2, MAPK1, EDN1, CREB3L1, WNT5A, PLCB3, FZD6, GSK3B",0.450996737974212,0.120904120499927,FALSE
+"transcriptomics","Log2FC","KEGG_MELANOMA",-0.26432,-0.951,0.453,16564,0.793,"PIK3R1, PIK3CG, FGF20, CDK6, FGF21, FGF2, PDGFRA, E2F2, NRAS, IGF1, FGF9, FGF4, CDKN2A, FGF5, FGFR1, E2F3, FGF19, FGF3",0.343901797987168,0.100726812682396,FALSE
+"transcriptomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.45636,1.31,0.105,3662,0.846,"ADH7, ALDH3B2, GSTK1, DHDH, CYP2E1, CYP1B1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, MGST2, UGT2B17, MGST3",0.978810700930062,0.0726296369609765,FALSE
+"transcriptomics","Log2FC","KEGG_MISMATCH_REPAIR",-0.32549,-1.13,0.294,15319,0.63,"MSH6, RFC3, MSH3, RFC2, RFC5, EXO1, MSH2, RFC1, RPA2",0.531652669587843,0.200659450546418,FALSE
+"transcriptomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35512,1.02,0.389,6050,0.795,"PIK3R2, VEGFB, MAPK3, RPS6KB2, PIK3CA, TSC1, CAB39, RICTOR, BRAF, PRKAA1, PGF, VEGFA, PIK3R3, HIF1A, RPS6KA2, DDIT4, VEGFC, RHEB, MAPK1, RPS6KA1, PIK3R5, PIK3CB, ULK1",0.410050398674292,0.0996328713435297,FALSE
+"transcriptomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.2602,0.751,0.859,6624,0.986,"ITGB2, VAV1, PIK3R2, PLCG2, RAC2, VAV3, RAET1L, MAPK3, PTPN6, VAV2, IFNB1, PIK3CA, SH3BP2, PTK2B, TNFSF10, BRAF, PLCG1, CHP1, PPP3CA, LCK, CSF2, PIK3R3, ULBP2, RAC1, IFNGR1, PAK1, BID, MAPK1, NFATC1, PIK3R5, PIK3CB, SYK, NFATC4, HCST, GRB2, CHP2",0.0660068361687577,0.0061230850587888,FALSE
+"transcriptomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.21335,0.617,0.956,5100,0.991,"DRD5, P2RY2, VIPR2, PTAFR, BDKRB2, P2RY6, P2RX4, LPAR2, VIPR1, S1PR4, THRB, GRIN1, NPBWR1, ADORA1, ADORA2B, ADORA2A, GIPR, S1PR2, GALR3, CGA, BDKRB1, GHSR, GABRP, F2RL3, GRIN2A, OPRL1, CHRNB4, MLNR, S1PR5, ADRB2, GRIN2D, P2RX6, EDNRA, F2RL1, MC3R, P2RX2, LTB4R2, HTR7, CHRNB1, ADRA2A, GRIN3B, GRM4, LTB4R, PRLR, ADRA2B, GH2",0.0195421077238999,0.00392634551472468,FALSE
+"transcriptomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.33316,0.965,0.496,5975,0.86,"GAB1, NTF4, PRKCD, TRAF6, MAPK13, PIK3R2, PLCG2, FOXO3, CALML3, ARHGDIB, IKBKB, CAMK2G, MAPK3, MAP3K1, SH2B2, PIK3CA, NTRK2, RAP1A, IRS2, TP73, BRAF, PLCG1, YWHAB, RELA, MAPK11, NGFR, IRAK4, BAD, YWHAZ, MAP3K5, PIK3R3, YWHAH, RPS6KA2, SORT1, CALML6, RPS6KA4, MAPKAPK2, CRKL, NGF, RAC1, BAX, MAPK1, MAP2K7, RPS6KA1, MAPK10, PIK3R5, IRS1, PIK3CB, NFKBIA",0.304518323509803,0.0655015487564323,FALSE
+"transcriptomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.264,0.761,0.824,4274,0.987,"QPRT, NMRK1, NADSYN1, NADK, NT5C1B",0.0840727883028842,0.00568284733036327,FALSE
+"transcriptomics","Log2FC","KEGG_NITROGEN_METABOLISM",0.31831,0.912,0.593,2116,0.964,"GLUL, HAL, GLS2, CA9",0.226945306635737,0.0159229660971692,FALSE
+"transcriptomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34339,0.989,0.455,4477,0.848,"CASP1, TRAF6, MAPK13, TAB3, IKBKB, MAPK3, TRIP6, CCL5, IL18, PYCARD, TAB1, RELA, CARD6, MAPK11, IL6, NOD1, NOD2, PSTPIP1, NLRP1",0.341988603342888,0.0716041477432862,FALSE
+"transcriptomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.55072,-1.98,0.00877,17605,0.159,"RAD50, PRKDC, NHEJ1, XRCC5",2.05700040663396,0.798602875679548,TRUE
+"transcriptomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.34338,0.99,0.464,3686,0.856,"ERBB2, RXRA, PIK3R2, PLCG2, FOXO3, MAPK3, PIK3CA, RASSF5, RXRB, EGFR, E2F1, BRAF, PLCG1, TGFA",0.333482019445119,0.0675262353228468,FALSE
+"transcriptomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.39588,1.15,0.228,5482,0.71,"DTX4, HES1, DVL3, DTX3L, JAG1, DTX2, RFNG, EP300, DLL1, LFNG, NOTCH3, APH1A, MFNG, DVL2, JAG2, NUMB, NOTCH1, KAT2A, HES5",0.642065152999546,0.148741651280925,FALSE
+"transcriptomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.30853,-1.12,0.24,15978,0.616,"RFC2, XPC, RFC5, GTF2H1, XPA, GTF2H3, ERCC3, CUL4A, ERCC8, CCNH, ERCC1, POLE3, RFC1, RPA2, GTF2H2",0.619788758288394,0.210419287835575,FALSE
+"transcriptomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39086,1.14,0.257,3600,0.714,"MAN1B1, RPN2, ALG12, ALG3, DPM1, MOGS, MGAT4A, MGAT1, B4GALT1, MGAT5B, STT3A, ALG2, B4GALT2",0.590066876668705,0.146301788223826,FALSE
+"transcriptomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.24959,0.725,0.88,7709,1,"OR4C6, OR10H2, OR2J3, OR11H4, OR8A1, OR2A12, OR2D3, GUCY2D, CALML3, OR8B8, CAMK2G, CLCA2, OR1G1, OR2A7, OR13H1, OR1I1, OR13D1, CNGB1, OR1F1, OR8G5, OR8G1, OR10A3, OR1M1, OR6Q1, OR1K1, OR5P2, OR10H1, OR10A4, OR4D2, OR2A2, CNGA4, OR52B4, CALML6, OR2D2, OR2B2, OR1J1, OR6B1, PRKACA, OR2A14, GUCA1B, OR52K1, OR9A2, OR10A6, OR4L1, OR10AD1, OR2S2, OR10S1, OR10A2, OR2A5, OR10K2, OR10A5, OR8S1, OR4X2, OR5P3, ADCY3, OR6C70, OR8D2, OR8B4, OR2L2, CAMK2D, OR10G3, PRKG2, OR4K1, PRKACG, GRK3, OR8D1, OR52I1, OR6A2",0.0555173278498314,0,FALSE
+"transcriptomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44426,-1.55,0.0515,14974,0.29,"DHFR, SHMT2, MTHFS, MTR, MTHFD2L, GART, MTHFD2, MTHFD1L, TYMS, ATIC",1.28819277095881,0.537602002101044,FALSE
+"transcriptomics","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.25168,-0.852,0.579,15742,0.967,"ITPR2, PPP2R5D, PPP3CC, ADCY7, PPP2R5C, PRKX, RPS6KA3, PTTG2, PPP2CB, PPP2R1B, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, ITPR1, ANAPC10, FBXO5, CDC20, PRKACB, PPP3R1, CDK1, SMC1A, CALM2, CCNB1, FBXO43, CPEB1, AR, PTTG1, YWHAQ, SGO1, SMC3, IGF1, PPP1CC, ANAPC13",0.237321436272564,0.0145735259169983,FALSE
+"transcriptomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",0.61199,1.79,0.00444,5940,0.424,"MANBA, NEU1, ENGASE, MAN2B2, MAN2C1, GLB1, FUCA1, HEXB, MAN2B1, GBA, HEXA, AGA",2.35261702988538,0.372634143407267,FALSE
+"transcriptomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",0.23049,0.669,0.947,6376,0.986,"NDUFV1, LHPP, ATP6V1C2, COX5B, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP5F1E, NDUFB7, NDUFS8, NDUFA3, NDUFV2, ATP6AP1, COX6C, UQCR10, COX6B2, SDHD, UQCR11, TCIRG1, NDUFB4, NDUFAB1, ATP6V1G1, UQCRB, ATP6V0A4, NDUFA6, UQCRHL, NDUFA5, UQCRC1, NDUFB5, COX15, ATP5MG, UQCRFS1, ATP6V1C1, UQCRC2, COX6A1, ATP6V1E1, NDUFA2, COX17, ATP5PD",0.0236500209967266,0.0061230850587888,FALSE
+"transcriptomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.49419,1.42,0.0706,4056,0.638,"GALNT12, GALNT3, GALNT7, GALNT6, B4GALT5, GCNT1, ST6GALNAC1, GCNT3, C1GALT1, GALNT15, ST3GAL1, GALNT11, GALNT9, B3GNT6",1.1511952989482,0.195179321278838,FALSE
+"transcriptomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.1914,0.552,0.994,5981,0.999,"TP53AIP1, CCNG2, CD82, SERPINB5, SFN, THBS1, TP73, ATR, PERP, SHISA5, EI24, GADD45B, ZMAT3, CCNE1, SIAH1, PIDD1, BID, IGFBP3, BAX, CHEK2, GADD45A, PTEN",0.00261361560268669,0.000434511774017692,FALSE
+"transcriptomics","Log2FC","KEGG_PANCREATIC_CANCER",0.34675,0.998,0.462,5894,0.842,"ERBB2, PLD1, PIK3R2, RALB, RAC2, VEGFB, IKBKB, MAPK3, RALGDS, PIK3CA, EGFR, E2F1, RALBP1, STAT3, BRAF, RELA, TGFA, BAD, PGF, VEGFA, PIK3R3, STAT1, TGFB3, RALA, VEGFC, RAC1, JAK1, TGFBR2, MAPK1, MAPK10, PIK3R5, PIK3CB",0.335358024443874,0.0746879085003505,FALSE
+"transcriptomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.31788,0.916,0.602,8542,0.964,"PANK2, PPCS, ENPP1, COASY, UPB1, PPCDC, BCAT2, DPYD, VNN2",0.220403508742175,0.0159229660971692,FALSE
+"transcriptomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.18037,-0.606,0.98,17631,1,"UBE2J2, ATP5F1C, NDUFA9, VDAC2, LRRK2, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, UCHL1, ATP5F1A, SLC18A2, PARK7, NDUFS5",0.00877392430750515,0,FALSE
+"transcriptomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.30571,-1.11,0.294,18248,0.572,"YWHAQ, TUBA1A, NCL, ROCK2, TUBB4A, ARHGEF2, TUBB2B, TUBB2A",0.531652669587843,0.242603971206976,FALSE
+"transcriptomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.2849,0.828,0.733,5981,1,"WNT3A, WNT9A, CBLC, CSF1R, WNT7B, CDH1, ERBB2, FZD10, LAMA3, TRAF6, FGF11, MMP9, RXRA, BCR, FGFR2, TRAF4, PLD1, PDGFA, PIK3R2, PLCG2, RALB, LAMB3, EGLN3, WNT7A, RAC2, WNT4, VEGFB, LAMC2, DVL3, IKBKB, MAPK3, RALGDS, PML, PDGFB, RARA, BMP2, FLT3LG, PIK3CA, JUP, RASSF5, WNT10A, FADD, RXRB, MET, IGF1R, FGF1, MAX, ITGA3, EP300, EGFR, GLI3, STAT5B, E2F1, DAPK1, RALBP1, FGFR3, ITGA2B, PPARG, CBLB, ARNT2, STAT3, BRAF, PLCG1, CDKN1B, RELA, TCF7L1, FZD4, TGFA, FOXO1, IL6, DVL2, MECOM, LAMA5, WNT11, RUNX1, BAD, PGF, PIAS3, LAMB1, EPAS1, ITGA2, VEGFA, FGF12, DAPK2, PIK3R3, HIF1A, STAT1, CCNA1, CCNE1, STK4, TGFB3, CRKL, PTCH1, RALA, MITF, SLC2A1, STAT5A, VEGFC, RAC1, JAK1, BID, TGFBR2, BAX, MAPK1, WNT5A, MAPK10, PIK3R5, TFG, PIK3CB, CEBPA, NFKBIA, PTEN",0.134896025358872,0,FALSE
+"transcriptomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.47895,1.39,0.0802,4741,0.659,"DHDH, UGT2B17, GUSB, RPEL1, DCXR",1.09582563171584,0.18111458540599,FALSE
+"transcriptomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.43515,1.27,0.12,5085,0.753,"PGLS, ALDOC, FBP1, PGM1, PFKL, FBP2, ALDOA, H6PD, G6PD, RPEL1, RBKS, DERA, PGM2",0.920818753952375,0.123205023799299,FALSE
+"transcriptomics","Log2FC","KEGG_PEROXISOME",0.42548,1.23,0.158,5270,0.722,"CAT, ACOT8, GSTK1, PRDX5, PEX11A, XDH, PXMP4, ACAA1, MVK, AGXT, PEX11G, PEX2, HMGCL, EPHX2, PAOX, IDH2, ACSL1, EHHADH, PEX11B, CROT, ABCD1, ACOX1, ACSL3, PEX10, PEX13, PEX26, SCP2, PEX7, MLYCD, SLC25A17, ABCD4, PEX1, ACSL5, ACSL6",0.801342913045577,0.141462802430361,FALSE
+"transcriptomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.40531,1.18,0.19,5148,0.703,"ALDH3B2, ALDH1A3, ALDH3B1, AOC2, NAA80, IL4I1, TAT, MAOA, MIF",0.721246399047171,0.153044674980176,FALSE
+"transcriptomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.30436,0.867,0.668,6064,0.975,"CDS1, DGKA, PIK3R2, PLCG2, INPP4B, PLCD1, CALML3, INPP4A, PIK3CA, PIP4K2C, CDS2, PLCG1, PIK3C2G, PIK3C2B, DGKH, INPP5K, IMPA2, PIK3R3, PIP5K1C, CALML6, DGKI, ITPR3, INPPL1, INPP5J, PIK3R5, PIK3CB, DGKE, PTEN, PLCB3",0.175223537524454,0.0109953843014632,FALSE
+"transcriptomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.31034,0.905,0.588,4098,0.963,"ALAD, CP, HMOX2, FTH1, UGT2B17, MMAB, GUSB, HMBS",0.230622673923862,0.0163737128754655,FALSE
+"transcriptomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.41424,1.2,0.182,5270,0.705,"RXRA, ACAA1, CPT1B, PPARA, PLIN1, CYP4A22, FABP6, ACSL1, RXRB, CPT2, CPT1C, EHHADH, SLC27A6, PLTP, SLC27A1, PPARG, ACOX1, ACSL3, SCD5, SLC27A4, SCP2, OLR1, ACSL5, ACSL6",0.739928612014925,0.151810883008601,FALSE
+"transcriptomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.20209,-0.707,0.827,14148,1,"ACOX2, HSD17B4, CYP7A1, HSD3B7, AKR1C4, CYP39A1, BAAT",0.0824944904474534,0,FALSE
+"transcriptomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.5701,1.67,0.00988,4719,0.337,"RFXANK, BLNK, RAG1, JAK3, CD40, ADA, CD79A, RAG2, CD19, IL7R, CIITA, LCK, CD4",2.00524305541237,0.472370099128661,FALSE
+"transcriptomics","Log2FC","KEGG_PRION_DISEASES",0.24524,0.707,0.912,5622,0.994,"MAPK3, CCL5, IL6, NOTCH1, PRKACA, IL1A, C9, BAX, MAPK1, EGR1",0.0400051616715838,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28022,-1.01,0.396,15860,0.704,"ADCY7, PRKX, RPS6KA3, CCNA2, AKT3, MAD2L2, BUB1, CDC25C, CDC23, PIK3R1, GNAI1, PIK3CG, CCNB2, ANAPC10, PRKACB, CDK1, CCNB3, CDC25A, CCNB1, MAPK8, CPEB1, IGF1, HSP90AB1, HSP90AA1, ANAPC13, PDE3A, PDE3B",0.402304814074488,0.152427340857888,FALSE
+"transcriptomics","Log2FC","KEGG_PROPANOATE_METABOLISM",0.35657,1.04,0.385,3581,0.764,"LDHC, ACSS2, ALDH6A1, ABAT, MCEE, EHHADH, PCCB, ACSS1",0.414539270491499,0.11690664142431,FALSE
+"transcriptomics","Log2FC","KEGG_PROSTATE_CANCER",0.26783,0.777,0.821,6422,1,"ERBB2, FGFR2, PDGFA, PIK3R2, IKBKB, MAPK3, PDGFB, PIK3CA, IGF1R, PDGFD, EP300, EGFR, E2F1, BRAF, CDKN1B, RELA, TCF7L1, CREB3L4, TGFA, FOXO1, BAD, PIK3R3, CCNE1, CREB3L3, CREB3L2, MAPK1, CREB5, CREB3L1, PIK3R5, PIK3CB, NFKBIA, PTEN, GSK3B, CDKN1A, CREB3",0.0856568428805592,0,FALSE
+"transcriptomics","Log2FC","KEGG_PROTEASOME",-0.31612,-1.05,0.337,15132,0.64,"PSMB5, PSMD4, PSMD6, PSMC5, PSMB4, PSMA6, PSMD7, PSMC1, PSMC6, PSMD1, PSMC4, PSMB7, PSMA4, PSMA1, PSMD8, PSMB1, POMP, PSMD14",0.472370099128661,0.193820026016113,FALSE
+"transcriptomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.31244,-1.11,0.273,16054,0.572,"SEC61A2, SEC11A, SRPRB, SRP72, SRP9, SRP19, SEC11C, SEC63",0.563837352959244,0.242603971206976,FALSE
+"transcriptomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.19349,0.562,0.991,8289,1,"GLS2, SLC9A3, SLC25A10, MDH1, SLC4A4, GLUD1, ATP1A2, AQP1, ATP1A1",0.00392634551472468,0,FALSE
+"transcriptomics","Log2FC","KEGG_PURINE_METABOLISM",-0.30249,-1.08,0.287,15717,0.603,"PNPT1, PRPS1, RRM2, ADCY7, PFAS, POLR3B, ENTPD8, POLR2L, RRM2B, PAICS, ADSL, APRT, GART, NPR2, RRM1, PDE6B, PNP, PRIM1, NME1, PDE6C, POLR3G, PDE8A, POLR3A, AK5, NME7, PPAT, PDE11A, PRIM2, POLE3, POLR2E, POLR3C, PDE1A, ATIC, ENTPD1, PDE4B, PDE4D, POLR2D, POLR1E, PDE3A, PDE3B, POLA1, PDE10A, PDE7B, PDE8B",0.542118103266008,0.219682687859849,FALSE
+"transcriptomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.25943,-0.935,0.464,14988,0.804,"DHODH, POLE, NT5E, NME2, UPP2, CAD, POLR2C, POLR3K, PNPT1, RRM2, POLR3B, ENTPD8, POLR2L, RRM2B, AK3, TXNRD1, DTYMK, RRM1, PNP, PRIM1, NME1, TYMS, POLR3G, POLR3A, NME7, PRIM2, POLE3, POLR2E, POLR3C, ENTPD1, POLR2D, POLR1E, UCK2, POLA1, CTPS1",0.333482019445119,0.0947439512515487,FALSE
+"transcriptomics","Log2FC","KEGG_PYRUVATE_METABOLISM",0.22031,0.635,0.947,1378,0.989,"LDHC, ACSS2, PC",0.0236500209967266,0.0048037084028206,FALSE
+"transcriptomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.28027,0.814,0.746,5612,1,"PAK6, SSH3, BDKRB2, MYH14, BAIAP2, FGF11, ITGB2, VAV1, FGFR2, ITGB6, PDGFA, PIK3R2, ITGB8, RAC2, VAV3, LIMK2, FGD3, ITGB4, ARHGEF4, MAPK3, PPP1CA, VAV2, GSN, PDGFB, PFN4, PIK3CA, PPP1CB, PIP4K2C, BDKRB1, FGF1, SSH2, PDGFD, ITGA3, EGFR, FGFR3, ITGA2B, BRAF, TIAM1, PXN, MYL9, TIAM2, ARHGAP35, PAK2, SLC9A1, ITGA2, WASL, FGF12, PIK3R3, PIP5K1C, LIMK1, CRKL, ARHGEF7, SCIN, MYL7, RAC1, IQGAP1, PAK1, RRAS, BCAR1, ITGAX, PAK4, MAPK1",0.127261172527331,0,FALSE
+"transcriptomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.20206,-0.654,0.892,18035,1,"PIK3C3, PRKAA2, IFNA13",0.0496351456238769,0,FALSE
+"transcriptomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3643,1.06,0.349,5894,0.757,"GAB1, PAK6, PIK3R2, EGLN3, VEGFB, MAPK3, PDGFB, PIK3CA, MET, EP300, RAP1A, ARNT2, BRAF, TGFA, PAK2, PGF, EPAS1, VEGFA, PIK3R3, HIF1A, TGFB3, CRKL, FLCN, SLC2A1, VEGFC, RAC1, PAK1, PAK4, MAPK1, PIK3R5, PIK3CB",0.45717457304082,0.120904120499927,FALSE
+"transcriptomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.39819,1.16,0.224,4025,0.723,"CTSA, ACE2, ACE, ANPEP",0.649751981665837,0.140861702705469,FALSE
+"transcriptomics","Log2FC","KEGG_RETINOL_METABOLISM",0.43832,1.25,0.138,5807,0.802,"ADH7, RDH16, CYP26B1, DHRS9, DHRS3, DGAT1, CYP4A22, CYP26A1, UGT2B17, CYP1A1, RDH10, RDH11, LRAT, CYP26C1, CYP2C9, CYP2A7, ALDH1A2, AWAT2, CYP2C8",0.860120913598763,0.0958256317158365,FALSE
+"transcriptomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.28656,0.836,0.738,3165,1,"ACP6, ACP5, MTMR1",0.131943638176958,0,FALSE
+"transcriptomics","Log2FC","KEGG_RIBOSOME",-0.37924,-1.32,0.141,14672,0.384,"RPL22L1, RPS23, RPL26, RPL21, RPL13A, RPS24, RPL10A, RPL37A, RPS11, RPS27A, RPL35, RPL10, RPL26L1, RPL34, RPL27A, RPLP0, RPL11, RPL32, RPS8, RPL18, RPS27, RPL9, RPS20, RPS10, RPS6, RPL4, RPL5, RPL14, RPSA, RPS13, RPS7, RPS19, RSL24D1, RPS12, RPL6, RPS4Y1, RPS16, RPL17",0.85078088734462,0.415668775632469,FALSE
+"transcriptomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.42041,1.21,0.17,3761,0.689,"TRADD, TRAF6, DHX58, MAPK13, MAVS, IRF3, CXCL10, IKBKB, IFNB1, MAP3K1, TKFC, FADD, ISG15, IFIH1, DDX58, NLRX1, IL12B, CASP10, RELA, MAPK11, IKBKE",0.769551078621726,0.161780778092374,FALSE
+"transcriptomics","Log2FC","KEGG_RNA_DEGRADATION",-0.39068,-1.29,0.137,15014,0.399,"CNOT7, LSM2, EXOSC6, LSM1, LSM5, CNOT1, PNPT1, DCP1A, LSM7, EDC4, LSM3, EXOSC9, CNOT10, EXOSC5, EXOSC3, PAPOLA, TTC37, ZCCHC7, EXOSC10, MTREX, ENO1, DCP2, CNOT9, ENO3, EXOSC8, HSPA9, DCP1B, HSPD1",0.863279432843593,0.399027104313252,FALSE
+"transcriptomics","Log2FC","KEGG_RNA_POLYMERASE",-0.36582,-1.32,0.123,17492,0.384,"POLR3G, POLR3A, POLR2E, POLR3C, POLR2D, POLR1E",0.910094888560602,0.415668775632469,FALSE
+"transcriptomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.20795,-0.742,0.911,17399,1,"SCLY, MAT2A, MARS2, SEPHS1, TRMT11",0.0404816230270017,0,FALSE
+"transcriptomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.2741,0.799,0.789,4622,1,"LAMA3, TRAF6, RXRA, TRAF4, PIK3R2, LAMB3, LAMC2, IKBKB, PIK3CA, RXRB, MAX, ITGA3, E2F1, ITGA2B, CDKN1B, RELA, LAMA5, PIAS3, LAMB1, ITGA2, PIK3R3",0.10292299679058,0,FALSE
+"transcriptomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.44073,1.28,0.118,4358,0.809,"SNAP23, STX16, STX10, VAMP8, STX19, YKT6, STX17, VTI1B, TSNARE1, STX3, GOSR2, SNAP29, BET1, USE1, STX5, BET1L",0.928117992693875,0.0920514783877277,FALSE
+"transcriptomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.24714,0.711,0.906,8272,1,"ARSA, SPTLC2, NEU1, ASAH1, PLPP3, DEGS2, SPHK2, GLB1, SPHK1, GBA, SGMS2, SGPP1, SPTLC1, ENPP7, UGCG, SMPD3, SMPD2, SGPP2, NEU2, SMPD1, UGT8",0.0428718023231869,0,FALSE
+"transcriptomics","Log2FC","KEGG_SPLICEOSOME",-0.28279,-0.976,0.362,14820,0.761,"HSPA1A, SNRNP27, DDX23, LSM2, SF3A3, SF3B1, SNRPB, SNRPF, PRPF8, BCAS2, LSM5, PRPF3, THOC1, SRSF3, SF3A2, DDX39B, EIF4A3, LSM7, SF3B4, TCERG1, RBM22, U2AF1, LSM3, SNRNP40, SYF2, DDX5, HNRNPK, DHX15, HNRNPA1L2, BUD31, PQBP1, PRPF40A, THOC2, PRPF4, SNRPA1, RBM8A, ALYREF, CDC5L, RBM17, SRSF7, SNRPE, PRPF18, SNRPD2, CDC40, SNRPC, RBMX, SRSF1, HNRNPA3, HSPA8, HNRNPM, HNRNPA1, HNRNPC, SF3B5, MAGOHB, PPIH, HNRNPU, PPIE, TXNL4A, SRSF10",0.441291429466834,0.118615343229427,FALSE
+"transcriptomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44369,1.3,0.112,7075,0.803,"HK2, GYS1, GCK, GAA, PGM1, GANC, UGT2B17, GUSB, HK1, UXS1, PYGL, PGM2, ENPP1, MGAM, PYGB, AMY1A, UGP2, AGL",0.950781977329818,0.095284454721319,FALSE
+"transcriptomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.61834,1.78,0.00564,5003,0.304,"MSMO1, DHCR24, LIPA, SC5D, SQLE, FDFT1, HSD17B7, CEL, NSDHL, DHCR7, LSS, TM7SF2",2.24872089601666,0.517126416391246,FALSE
+"transcriptomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38862,1.13,0.264,4669,0.706,"CYP11B1, CYP1B1, SULT2B1, SRD5A1, COMT, SRD5A3, CYP7B1, UGT2B17, HSD17B7, SULT1E1, CYP1A1, HSD17B8",0.578396073130169,0.151195298948196,FALSE
+"transcriptomics","Log2FC","KEGG_SULFUR_METABOLISM",0.55174,1.6,0.0215,5093,0.351,"SULT2B1, CHST12, SULT1A2, SUOX, SULT1A4, CHST11, SULT1E1, SULT1A3",1.66756154008439,0.454692883534176,FALSE
+"transcriptomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.21402,-0.738,0.905,18576,1,"SSB, GRIN2B",0.0433514207947967,0,FALSE
+"transcriptomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.22218,0.648,0.942,6205,0.987,"KCNB1, SCNN1A, ADCY4, TAS2R1, SCNN1G, TAS1R3, ADCY6, GNAS, TAS2R3, GRM4, TAS2R31, SCNN1B, ITPR3, PRKACA, TAS2R4, TAS2R38, TAS2R5",0.0259490972071227,0.00568284733036327,FALSE
+"transcriptomics","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.24456,0.709,0.925,3450,1,"GGT7, GGT6",0.0338582672609674,0,FALSE
+"transcriptomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.41775,1.22,0.183,5412,0.694,"MVK, HMGCS1, MVD, DHDDS, HMGCR",0.737548910269571,0.158640529545145,FALSE
+"transcriptomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21463,-0.768,0.793,15652,1,"SMAD7, TFDP1, RHOA, BMPR2, SMAD5, PITX2, BMP8B, PPP2CB, PPP2R1B, ID3, SMAD4, SKP1, SMURF2, BMPR1A, INHBE, SMAD9, BMP8A, ID2, TGFB1, CDKN2B, E2F5, ROCK2, BMP6, SMAD2",0.100726812682396,0,FALSE
+"transcriptomics","Log2FC","KEGG_THYROID_CANCER",0.39121,1.13,0.263,3392,0.706,"CDH1, RXRA, MAPK3, RXRB, PPARG, BRAF, TCF7L1",0.580044251510242,0.151195298948196,FALSE
+"transcriptomics","Log2FC","KEGG_TIGHT_JUNCTION",0.33254,0.971,0.509,4350,0.873,"EPB41L1, PRKCD, AMOTL1, MYH14, CLDN8, CGN, CLDN9, CLDN7, CLDN4, F11R, TJP3, CRB3, TJP2, PRKCH, LLGL2, CLDN18, PRKCI, PARD6B, PATJ, CLDN11, CTTN, EXOC4, CLDN23, CLDN3, SRC, MYH15, MYL9, EXOC3, MAGI1, PRKCZ, OCLN",0.293282217663241,0.0589857562944303,FALSE
+"transcriptomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43206,1.24,0.16,6260,0.758,"TLR5, TRAF6, MAPK13, PIK3R2, IRF5, LBP, IRF3, TOLLIP, CXCL10, IKBKB, MAPK3, TLR3, IFNB1, PIK3CA, MYD88, FADD, CXCL11, CCL5, CD40, IL12B, CXCL9, TAB1, RELA, TLR1, MAPK11, IKBKE, IL6, TLR2, MAP3K8, IRAK4, TIRAP, TICAM1, PIK3R3, STAT1, IL12A, RAC1, TAB2, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB, NFKBIA, FOS, IRF7",0.795880017344075,0.120330794367946,FALSE
+"transcriptomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.25994,0.765,0.827,5698,1,"CAT, CYP1B1, GCDH, KMO, EHHADH, IL4I1, CYP1A1, MAOA, IDO1, HAAO, OGDHL",0.0824944904474534,0,FALSE
+"transcriptomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.35999,1.05,0.372,1965,0.765,"PRKCD, HK2, PIK3R2, CACNA1D, SOCS1, GCK, IKBKB, MAPK3, INSR, PIK3CA",0.429457060118102,0.116338564846382,FALSE
+"transcriptomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",-0.22684,-0.768,0.784,16990,1,"PRF1, PTPRN, HSPD1",0.105683937315562,0,FALSE
+"transcriptomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.48583,1.41,0.0488,2773,0.629,"ADH7, ALDH3B2, HEMK1, TH, ALDH1A3, ALDH3B1, COMT, AOC2, GSTZ1, NAA80, LCMT1",1.31158017799729,0.201349354554731,FALSE
+"transcriptomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29483,0.845,0.714,6624,1,"PAK6, CBLC, VAV1, MAPK13, PIK3R2, VAV3, DLG1, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, NCK2, CBLB, PLCG1, RELA, CHP1, MAPK11, PPP3CA, PAK2, LCK, MAP3K8, CSF2, PIK3R3, CD4, NCK1, PAK1, PAK4, MAPK1, MAP2K7, NFATC1, PIK3R5, PIK3CB, NFKBIA, GSK3B, FOS, NFATC4, GRB2, CHP2",0.146301788223826,0,FALSE
+"transcriptomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29203,0.84,0.732,6099,1,"CBLC, UBOX5, ITCH, UBA7, TRAF6, UBE2H, PPIL2, SOCS1, FBXO2, SMURF1, PML, MAP3K1, FBXW7, UBE2L6, RHOBTB2, HERC1, HERC3, ANAPC2, CUL7, UBE2D4, CBLB, FBXO4, RNF7, MID1, SYVN1, UBA6, FBXW8, UBR5, UBE2C, PIAS3, KLHL13, UBE3B, UBE2W, HUWE1, NEDD4L, UBE2F, TRIM32, UBE2Q1, WWP2, DDB1, SIAH1, FZR1, UBE4A, UBE2E1, UBE3C, DET1, UBE2O, UBE2E2, STUB1, UBA3, ANAPC11, UBE2M, UBE2Z",0.135488918941608,0,FALSE
+"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.54815,-1.93,0.00901,13596,0.141,"VARS2, LARS2, BCAT1, PDHA1, IARS2",2.04527520902094,0.85078088734462,TRUE
+"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.42231,1.22,0.176,3822,0.694,"MCCC1, ACAA1, HIBADH, ACAD8, ALDH6A1, ABAT, HMGCL, HMGCS1, MCEE, ACADS, EHHADH, PCCB, IL4I1, AUH",0.75448733218585,0.158640529545145,FALSE
+"transcriptomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28813,0.843,0.705,4348,1,"PRKCD, PLA2G12A, KCNMB3, CACNA1D, PLA2G6, CALML3, PLA2G4B, ADORA2B, MAPK3, ADORA2A, PPP1CA, PRKCH, ADCY5, CYP4A22, PPP1CB, ADCY4, PLA2G10, PLA2G4E, BRAF, ADCY6, MYL9, PLA2G2C, EDNRA, KCNMB4, GNAS, GNAQ",0.151810883008601,0,FALSE
+"transcriptomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.27394,0.798,0.794,7785,0.999,"DYNLL2, AQP3, RAB5B, ARHGDIB, ADCY6, CREB3L4, GNAS, DYNC2LI1, DCTN5, CREB3L3, PRKACA, CREB3L2, RAB11B, RAB5C, CREB5, CREB3L1, CREB3, ADCY9, ADCY3, NSF, CREB1, RAB11A, PRKACG, DCTN1",0.100179497572904,0.000434511774017692,FALSE
+"transcriptomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.37587,1.09,0.31,5894,0.754,"PLA2G12A, MAPK13, PIK3R2, PLCG2, RAC2, PLA2G6, PLA2G4B, NOS3, HSPB1, MAPK3, PIK3CA, PLA2G10, PLA2G4E, MAPKAPK3, PLCG1, SPHK2, PXN, SRC, CHP1, MAPK11, PPP3CA, PLA2G2C, BAD, VEGFA, PIK3R3, SPHK1, MAPKAPK2, RAC1, MAPK1, NFATC1, PIK3R5, PIK3CB",0.508638306165727,0.122628654130226,FALSE
+"transcriptomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.35881,1.03,0.379,7679,0.784,"ERO1A, PLCG2, ATP6V1C2, TJP2, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP6AP1, KDELR3, PLCG1, PDIA4, GNAS, TCIRG1, KCNQ1, ATP6V1G1, SEC61G, ATP6V0A4, PRKACA, KDELR2, ATP6V1C1, TJP1, ATP6V1E1, ADCY9, ADCY3, SEC61B, ATP6V0C, PRKACG, ATP6V1E2, ATP6V0E2",0.421360790031928,0.105683937315562,FALSE
+"transcriptomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.26233,0.758,0.85,3633,0.983,"MYH14, ITGB2, RAC2, DAG1, CD40, EIF4G1, CAV1, MYH15",0.0705810742857073,0.00744648216786438,FALSE
+"transcriptomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.25146,0.722,0.896,2541,1,"WNT3A, WNT9A, TBL1XR1, WNT7B, DAAM1, FZD10, PORCN, WNT7A, RAC2, SENP2, WNT4, FRAT1, CTNNBIP1, DVL3, CAMK2G, FRAT2, CSNK1E, WNT10A, LRP5, CSNK1A1, EP300, VANGL2",0.0476919903378748,0,FALSE
+"proteomics","Log2FC","KEGG_ABC_TRANSPORTERS",-0.56716,-1.64,0.0417,8609,0.499,"ABCC5, ABCA1, ABCG1, ABCA10, ABCB1, ABCC10, ABCB7, ABCB5, ABCC1, ABCC4, ABCC6, ABCB4, ABCB10, ABCA7, ABCA3, ABCA13, ABCC2, ABCB11",1.37986394502624,0.30189945437661,FALSE
+"proteomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.42626,1.21,0.202,2845,0.592,"PIK3CD, RARA, RUNX1, LEF1, CCND1, KRAS, NRAS, FLT3, PIK3R2, PIK3CA, STAT3, IKBKB, HRAS, EIF4EBP1, MAPK3, GRB2, RPS6KB2, SOS2, TCF7L1, MAPK1",0.694648630553376,0.22767829327708,FALSE
+"proteomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.47199,1.33,0.131,1296,0.6,"RAC2, NECTIN4, CDH1, SNAI2, CTNND1, ACTN3, CTNNA1, NECTIN1, CTNNA2, CTNNB1, BAIAP2, ERBB2, RAC3, EP300, LMO7, PTPN6, PTPRF, EGFR, LEF1",0.882728704344236,0.221848749616356,FALSE
+"proteomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.31768,0.895,0.589,2689,0.966,"CD36, RXRA, RXRG, IRS1, ACSL4, ACSL1, PRKCQ, ACSL6, SLC2A1, ACSL5, STAT3, IKBKB, NFKBIA, PRKAB2, ACSL3",0.229884705212898,0.0150228735845067,FALSE
+"proteomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.24638,0.704,0.866,2010,1,"GLUL, ABAT, GLUD2, GFPT1, GPT2",0.0624821079826534,0,FALSE
+"proteomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.56793,1.61,0.0442,3523,0.604,"SCNN1A, ATP1A2, PIK3CD, IRS1, PDPK1, KRAS, HSD11B2, PIK3R2, PIK3CA, MAPK3, SCNN1B, MAPK1, SFN, ATP1A3, ATP1A4, ATP1A1, PRKCG",1.35457773065091,0.218963061378868,FALSE
+"proteomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.58978,1.66,0.0378,2132,0.778,"FADS2, PLA2G12A, PLA2G2A, ACOX1, ACOX3",1.42250820016277,0.109020403010311,FALSE
+"proteomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",-0.26665,-0.77,0.751,8102,0.905,"PSEN1, NDUFV1, UQCRC1, COX7A2, NDUFA6, ERN1, NDUFC1, BAD, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, MAPT, ATP5PF, NDUFB4, HSD17B10, NDUFA3, ITPR2, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, IDE, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, PPP3CC, ITPR1, PLCB2, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5MC2, BACE2, CASP7, PLCB4, PSEN2",0.124360062995832,0.0433514207947967,FALSE
+"proteomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.38256,-1.1,0.308,7208,0.573,"AARS2, FARSB, FARS2, SARS2, LARS2, DARS2, YARS2, MTFMT, EARS2, WARS2, RARS2",0.511449283499556,0.24184537803261,FALSE
+"proteomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.27352,0.759,0.793,2412,1,"HK1, MPI, NPL, RENBP, PGM1, NAGK, GMPPA, GFPT1, HK2, GALT, PGM2, GALE",0.100726812682396,0,FALSE
+"proteomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.34389,-1.01,0.395,10318,0.62,"NEFM, MAP2K6, MAPK11, SOD1, NEFL, PRPH, PRPH2, NEFH",0.40340290437354,0.207608310501746,FALSE
+"proteomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32022,0.897,0.599,3597,0.975,"CTSS, IFI30, CD74, CALR, LGMN, HSPA6, TAPBP, HSPA1A, PSME2, CREB1, PSME1, CTSB",0.222573177610689,0.0109953843014632,FALSE
+"proteomics","Log2FC","KEGG_APOPTOSIS",0.23693,0.675,0.897,2534,1,"IL1R1, BCL2, IL1RAP, ENDOD1, PIK3CD, CASP10, MYD88, PPP3R1, PPP3CA, PPP3CB, PPP3R2, PIK3R2, TP53, CASP6, PIK3CA, IKBKB, PRKAR1B, CAPN2, NFKBIA, ENDOG",0.0472075569559079,0,FALSE
+"proteomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.4694,1.31,0.153,2120,0.557,"GGT5, PTGS2, PLA2G12A, EPHX2, ALOX5, GPX6, GPX7, PTGES, PLA2G2A, GPX1, GGT7, GPX3",0.815308569182401,0.254144804826271,FALSE
+"proteomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34932,0.98,0.438,2841,0.894,"GLUL, OAT, PRODH, PRODH2, GATM, ARG1, NOS3, CKMT1A, CKMT2, GLUD2, NOS1, P4HA2, NAGS, ARG2, P4HA1, PYCR3, MAOA, ASL, OTC, ALDH18A1",0.3585258894959,0.0486624812040823,FALSE
+"proteomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.33473,0.934,0.498,1866,0.938,"ITGB6, ITGB8, ACTN3, CTNNA1, ITGB4, CTNNA2, CTNNB1, DSC2, ITGA2, ITGA11, SGCG, LEF1, ITGA4, CACNA1F, GJA1, ITGA3, PKP2",0.302770657240282,0.0277971616209356,FALSE
+"proteomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.61182,-1.83,0.0219,7847,0.343,"ALDH9A1, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",1.65955588515988,0.464705879957229,FALSE
+"proteomics","Log2FC","KEGG_AXON_GUIDANCE",0.46405,1.32,0.135,2598,0.577,"RAC2, PAK5, PAK6, NGEF, EPHA1, EPHB2, RGS3, ROBO2, NTN4, SEMA4B, NFATC4, EFNB2, EFNA1, SEMA7A, RAC3, PLXNB2, PPP3R1, SEMA3A, SEMA3C, PPP3CA, PPP3CB, PLXNA2, EPHB4, PPP3R2, EPHA4, SEMA4D, KRAS, NRAS, SLIT2, EPHB3, EPHB1, RHOA, NFATC1, SLIT1, SLIT3, RAC1, MET, LIMK2, HRAS, MAPK3, PLXNA1, ABLIM1, NFATC3, NTN1, NFATC2, RHOD",0.869666231504994,0.238824186844269,FALSE
+"proteomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",-0.25512,-0.732,0.811,10364,0.917,"WNT10A, GLI2, GLI3",0.090979145788844,0.0376306643299789,FALSE
+"proteomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.41284,-1.22,0.214,7232,0.5,"GTF2A1, STON1, GTF2E2, TAF10, TBP, GTF2H3, GTF2A2, GTF2F2, GTF2H4, GTF2H1, TAF12, GTF2H2, GTF2F1, TAF13, TBPL1",0.669586226650809,0.301029995663981,FALSE
+"proteomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.24796,-0.718,0.793,9965,0.926,"POLL, NTHL1, MUTYH",0.100726812682396,0.0333890133180656,FALSE
+"proteomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.28968,-0.846,0.648,7434,0.779,"SRM, ECHS1, MLYCD, ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",0.188424994129407,0.108462542327436,FALSE
+"proteomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.35293,-1.03,0.382,9642,0.626,"HACD1, YOD1, PECR, ACOT7, ELOVL2",0.417936637088291,0.20342566678957,FALSE
+"proteomics","Log2FC","KEGG_BLADDER_CANCER",0.463,1.32,0.138,2596,0.577,"CDH1, VEGFA, THBS1, ERBB2, VEGFC, EGFR, CDK4, CCND1, KRAS, NRAS, CDKN1A, MMP2, TP53, HRAS, MAPK3, CDKN2A",0.860120913598763,0.238824186844269,FALSE
+"proteomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.29975,0.848,0.662,891,0.999,"ABAT, HMGCS1, ACSM3, BDH2",0.1791420105603,0.000434511774017692,FALSE
+"proteomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.52452,1.47,0.0703,2561,0.621,"RAC2, DAPP1, CARD11, NFATC4, PIK3CD, RAC3, LYN, CD79A, PTPN6, PIK3AP1, PPP3R1, VAV1, PPP3CA, VAV2, PPP3CB, PPP3R2, KRAS, NRAS, CD81, NFATC1, PIK3R2, RAC1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, VAV3, GRB2, NFATC3, NFATC2, SOS2",1.15304467498018,0.20690839982342,FALSE
+"proteomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.24843,0.694,0.888,1708,1,"TNNC1, ERBB3, GNA15, TNNC2, NOS3, ERBB2, ERBB4, ATP2A3, PPP3R1, EGFR, PPP3CA, PPP3CB, PPP3R2, NOS1, PTK2B, CACNA1F, CACNA1A",0.051587034221399,0,FALSE
+"proteomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.35378,0.998,0.432,840,0.878,"TNNC1, MYH7, ATP1A2, SLC9A1",0.364516253185088,0.0565054840938974,FALSE
+"proteomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.48094,1.35,0.128,793,0.579,"CLDN18, CLDN4, CLDN7, CDH15, CDH3, CDH5, SDC4, ITGAL, SDC1, ITGB8, ITGB2, CLDN3, CDH1, F11R, CLDN6, VCAN, JAM2, SDC2, NECTIN1, SDC3, CD274, ICAM2",0.892790030352132,0.237321436272564,FALSE
+"proteomics","Log2FC","KEGG_CELL_CYCLE",0.18042,0.51,0.998,2700,1,"FZR1, CDC6, WEE1, EP300, CDC7, CHEK2, ANAPC11, CDKN1C, CDK4, SKP2, CCND1, CCNB1, BUB1, CDKN1A, CCNA2, RBL1, CREBBP, TP53, PCNA, CHEK1, BUB1B, CDKN2A, HDAC1, ZBTB17",0.000869458712628891,0,FALSE
+"proteomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28479,-0.834,0.658,10271,0.79,"PLCB4, CXCL10, DOCK2, ADCY6, GNG7, SHC4, CCR10, CCR9, WAS, CXCL5, RASGRP2, CXCL14",0.181774106386044,0.102372908709559,FALSE
+"proteomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.23803,0.668,0.922,2652,0.989,"PIK3CD, MECOM, RUNX1, CDK4, CCND1, KRAS, NRAS, CDKN1A, BCR, PIK3R2, TP53, PIK3CA, CTBP1, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, GRB2, SOS2, CDKN2A, HDAC1",0.0352690789463706,0.0048037084028206,FALSE
+"proteomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.51999,1.46,0.0816,2428,0.603,"BHLHE41, PER2, NR1D1, CSNK1E, ARNTL",1.08830984124614,0.219682687859849,FALSE
+"proteomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.18745,-0.537,0.992,2896,1,"IDH1, SUCLG2, ACO1, DLD, ACLY, ACO2, DLST, PCK1, MDH2, MDH1, SDHA, SUCLG1, OGDHL, DLAT, OGDH, PC, SUCLA2, IDH3B, SDHB, CS, SDHC, IDH3A, PDHB, PDHA1, IDH3G, FH, SDHD, PCK2",0.00348832784582135,0,FALSE
+"proteomics","Log2FC","KEGG_COLORECTAL_CANCER",0.32298,0.918,0.522,2210,0.965,"RAC2, BCL2, CTNNB1, PIK3CD, RAC3, LEF1, CCND1, KRAS, RHOA, PIK3R2, TP53, RAC1, PIK3CA",0.282329496997738,0.0154726866562074,FALSE
+"proteomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.403,1.13,0.261,944,0.723,"CFI, CFB, SERPINA1, TFPI, FGG, FGB, SERPINA5, MASP1, PLAT, PLAU, SERPINC1, F3",0.583359492661719,0.140861702705469,FALSE
+"proteomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.39207,-1.14,0.242,8054,0.565,"APIP, GOT1, MAT2B, SDS, GOT2, CBS, MAT2A, MAT1A, MTAP, AMD1, CDO1",0.616184634019569,0.247951552180562,FALSE
+"proteomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.46198,-1.37,0.124,10106,0.559,"TNFRSF10A, TGFB1, BMPR2, CXCL10, INHBA, TNFRSF19, ACVR2A, CD70, TNFSF9, TGFB2, CD40, BMPR1A, TNFRSF10C, CCR10, CCR9, IL1A, IFNAR2, CXCL5, INHBE, CXCL14, PDGFRA",0.906578314837765,0.252588192113577,FALSE
+"proteomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.16559,0.457,0.998,2883,1,"CASP1, RIPK3, DDX58, IL18, IKBKB, NFKBIA, IKBKE, IL1B",0.000869458712628891,0,FALSE
+"proteomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",-0.30863,-0.921,0.504,10453,0.695,"ADCY6, TGFB2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.297569463554475,0.158015195409886,FALSE
+"proteomics","Log2FC","KEGG_DNA_REPLICATION",-0.20491,-0.606,0.968,2252,0.988,"PCNA, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, POLE4, POLD3, RFC4, MCM4, POLE3, MCM6, POLD1, MCM5, MCM7, RPA2, SSBP1, RNASEH2A, MCM3, POLE2, POLD2, FEN1, PRIM1, RPA1, MCM2, DNA2, RNASEH1, PRIM2, POLA1, POLA2, RNASEH2C, RNASEH2B",0.0141246426916063,0.00524305541237188,FALSE
+"proteomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55702,1.54,0.0554,2561,0.546,"ETS2, ETV6, EGFR, NOTCH3, KRAS, PIWIL2, MAPK3, GRB2, SOS2",1.25649023527157,0.262807357295263,FALSE
+"proteomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.35951,1.01,0.407,1430,0.862,"FMO5, GSTA5, ADH4, ADH7, FMO2, FMO4, MGST2, ALDH1A3, MGST1, ALDH3B1, FMO3",0.39040559077478,0.0644927341752872,FALSE
+"proteomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42011,-1.27,0.169,9395,0.538,"GMPS, CYP3A5, UCK2, UMPS, NAT2, CYP3A7",0.772113295386326,0.269217724333611,FALSE
+"proteomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.43662,1.21,0.204,1082,0.592,"ITGB6, TNC, SDC4, CD36, SDC1, ITGB8, ITGB4, SDC2, LAMC2, LAMB3, THBS1, SDC3, CD47, ITGA2, ITGA11, LAMA3, LAMA4",0.690369832574101,0.22767829327708,FALSE
+"proteomics","Log2FC","KEGG_ENDOCYTOSIS",0.2991,0.83,0.675,2726,1,"EPN3, PSD4, ERBB3, ARRB1, CHMP2B, ASAP3, RAB11FIP1, RAB11FIP4, ERBB4, DNAJC6, ARAP3, EGFR, GRK2, AGAP1, TRAF6, PRKCZ, AGAP2, RAB22A, EHD2, PRKCI, PARD6G, ITCH, ARF6, RAB11B, RAB31, RAB11A, CHMP4C, MET, LDLRAP1, CHMP4A, CHMP4B, CHMP2A, CLTCL1, PARD6B, HRAS, EPS15, CBLB, IGF1R, HSPA6, VPS37B, RAB5B, PARD6A, EPN1",0.170696227168975,0,FALSE
+"proteomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.50929,1.44,0.0828,2624,0.611,"CDH1, CTNNA1, CTNNA2, CTNNB1, ERBB2, PIK3CD, EGFR, LEF1, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, TCF7L1",1.08196966321512,0.213958789757446,FALSE
+"proteomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.31162,0.882,0.569,1141,0.985,"CXCL1, F11R, JAM2, MAPK12, MAPK13, LYN, EGFR",0.244887733604929,0.00656376950238827,FALSE
+"proteomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.41192,1.12,0.282,2561,0.698,"EREG, ERBB3, AREG, PAK5, PAK6, TGFA, ERBB2, PIK3CD, ERBB4, EGFR, GAB1, KRAS, NRAS, CDKN1A, PIK3R2, PIK3CA, HRAS, EIF4EBP1, MAPK3, CAMK2D, ABL2, CBLB, GRB2, RPS6KB2, SOS2",0.549750891680639,0.156144577376839,FALSE
+"proteomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.4815,1.35,0.123,2108,0.579,"LPCAT2, PLA2G12A, PAFAH2, PLA2G2A, LPCAT4, LPCAT1, PLPP3",0.910094888560602,0.237321436272564,FALSE
+"proteomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.299,0.836,0.662,2361,1,"ADH4, ADH7, ACSL4, ACAA1, ACSL1, ACOX1, CPT2, ACSL6, ADH1C, ACOX3, ACADM, ACSL5, ACADS",0.1791420105603,0,FALSE
+"proteomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.46449,1.3,0.156,2664,0.54,"RAC2, PRKCD, MAPK12, PIK3CD, MAPK13, PLA2G12A, RAC3, LYN, VAV1, LCP2, VAV2, PLA2G2A, PDPK1, KRAS, NRAS, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, SOS2, MAPK14",0.806875401645538,0.267606240177031,FALSE
+"proteomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3637,1.01,0.394,2557,0.862,"RAC2, PRKCD, AMPH, ASAP3, SCIN, PIK3CD, LYN, VAV1, GSN, MYO10, HCK, VAV2, MARCKS, MARCKSL1, PLA2G4F, ARF6, PTPRC, PIK3R2, PLPP3, RAC1, PIK3CA, LIMK2, MAPK3, VAV3, RPS6KB2",0.404503778174426,0.0644927341752872,FALSE
+"proteomics","Log2FC","KEGG_FOCAL_ADHESION",0.29325,0.826,0.673,1355,0.998,"ITGB6, TNC, RAC2, BCL2, PAK5, PAK6, ITGB8, VEGFA, ACTN3, ITGB4, LAMC2, LAMB3, THBS1, CTNNB1, ERBB2, VEGFC, PIK3CD, RAC3, VAV1, ITGA2, ITGA11, LAMA3, LAMA4, EGFR, VAV2, PDPK1, CCND1",0.171984935776023,0.000869458712628891,FALSE
+"proteomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.38519,1.09,0.304,2050,0.708,"ALPI, ALPP, ALPG, FPGS, PTS",0.517126416391246,0.149966742310231,FALSE
+"proteomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.59056,1.64,0.0309,2113,0.705,"ALDOB, FBP1, ALDOC, PFKFB4, MTMR7, HK1, FBP2, PFKFB2, MPI, GMPPA, MTMR1, HK2",1.51004152057517,0.151810883008601,FALSE
+"proteomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.35287,0.983,0.414,2908,0.903,"B4GALT1, HK1, PGM1, HK2, GAA, GALT, PGM2, GALE, UGP2, MGAM",0.382999658879101,0.0443122496864942,FALSE
+"proteomics","Log2FC","KEGG_GAP_JUNCTION",-0.39068,-1.15,0.249,9590,0.564,"GNAI1, ITPR1, PLCB2, TUBA8, TUBA3C, TUBB6, GRM5, PLCB4, MAP2K5, ADCY6, TUBB2B, PDGFRA",0.603800652904264,0.248720896016658,FALSE
+"proteomics","Log2FC","KEGG_GLIOMA",-0.32991,-0.968,0.426,10540,0.672,"CDK6, SHC4, PDGFRA",0.370590400897281,0.172630726946175,FALSE
+"proteomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.28325,0.784,0.727,2603,1,"GGT5, GSTA5, MGST2, GPX6, GPX7, MGST1, GSTK1, GPX1, IDH2, GGT7, GPX3, MGST3, G6PD, ANPEP, GSTT2",0.138465589140962,0,FALSE
+"proteomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.32775,0.901,0.55,2176,0.98,"LIPC, LPL, MGLL, LIPG, DGKA, DGKH, MBOAT2, DGKB, PLPP3, DGAT1",0.259637310505756,0.00877392430750515,FALSE
+"proteomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.34171,0.973,0.439,3460,0.895,"PEMT, DGKA, LPCAT2, PLA2G12A, CDS1, DGKH, PLA2G2A, CHKA, LPCAT4, MBOAT2, LPCAT1, DGKB, LYPLA2, PLPP3, PISD, PCYT2, LPGAT1, GPD1L, MBOAT1, DGKZ, PLA2G4A, GPD2, CHKB, LPCAT3, DGKQ",0.357535479757879,0.048176964684088,FALSE
+"proteomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.30658,-0.898,0.525,9064,0.714,"CBS, AGXT, ALAS1, PHGDH, PIPOX, PSAT1, MAOB, GLDC",0.279840696594043,0.146301788223826,FALSE
+"proteomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.45991,1.3,0.152,881,0.54,"ALDOB, PGAM2, FBP1, ALDOC, ADH4, ADH7, GALM, HK1, FBP2, ACSS2, ALDH1A3",0.818156412055227,0.267606240177031,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34596,-1.01,0.419,9904,0.62,"XYLT1, CSGALNACT2, CHST3, CHST7",0.377785977033705,0.207608310501746,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34182,0.955,0.473,3070,0.911,"HS6ST2, HS6ST1, XYLT2, EXT2, EXT1, EXTL3",0.325138859262188,0.0404816230270017,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66613,1.85,0.0202,2887,0.771,"B4GALT1, FUT8, B4GALT3, ST3GAL1, B3GNT2, B4GALT4",1.69464863055338,0.112945621949043,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.43357,-1.24,0.181,9910,0.545,"HEXA, IDUA, ARSB, HYAL1",0.742321425130815,0.263603497723358,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51004,-1.44,0.103,7952,0.644,"HEXB, ST3GAL5, HEXA, B4GALNT1",0.987162775294828,0.191114132640188,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.56837,1.6,0.0392,725,0.562,"B3GALNT1, B3GALT5",1.40671393297954,0.250263684430939,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62329,1.74,0.0218,2178,0.895,"B3GNT3, FUT3, B4GALT1, B3GALT5, B4GALT3, ST3GAL4, B3GNT2",1.6615435063954,0.048176964684088,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.25881,-0.746,0.767,8687,0.907,"PIGN, PIGQ, PIGB, PIGM, PIGX",0.115204636051019,0.0423927129399047,FALSE
+"proteomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.16598,0.463,0.998,4328,1,"AFMID, GLYCTK, ACO1, ACO2, MDH2, MTHFD2L, MDH1, MTHFD1",0.000869458712628891,0,FALSE
+"proteomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.23616,0.655,0.922,3427,0.993,"PRKCD, MAPK12, MAPK13, PLA2G12A, CGA, EGFR, PLA2G2A, KRAS, NRAS, PTK2B, CACNA1F, MAP3K1, MMP2, PLCB1, HRAS, MAPK3, CAMK2D, GRB2, SOS2, MAPK14, MAPK1, PLA2G4A, MMP14, GNA11, ADCY9, CDC42, CAMK2B, PLCB3, SOS1, ADCY5",0.0352690789463706,0.00305075150461883,FALSE
+"proteomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30481,-0.899,0.559,10364,0.725,"WNT10A, GLI2, GLI3",0.252588192113577,0.139661993429006,FALSE
+"proteomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.29233,0.812,0.721,1843,0.992,"IL1R1, CD36, CD9, ITGA2, ITGA4, ITGA3, FLT3, CD33",0.142064735280571,0.00348832784582135,FALSE
+"proteomics","Log2FC","KEGG_HISTIDINE_METABOLISM",-0.34944,-1.04,0.365,10443,0.638,"ALDH2, MAOB, ALDH7A1, ALDH3A1",0.437707135543525,0.195179321278838,FALSE
+"proteomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",-0.38362,-1.13,0.277,9496,0.552,"RAD50, MUS81, MRE11, RAD52",0.557520230935551,0.258060922270801,FALSE
+"proteomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.35692,-1.05,0.346,7298,0.634,"NDUFV2, COX7C, POLR2L, NDUFS4, SDHB, NDUFB5, POLR2I, COX4I1, POLR2A, SDHC, COX6B1, DCTN4, COX6A1, POLR2E, CYCS, DCTN2, DNAL1, TBP, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, POLR2H, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, BAX, NDUFA2, DCTN1, TFAM, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, HIP1, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, DNAH3, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, TGM2, ATP5F1C, SOD2, AP2A2, ITPR1, PLCB2, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, TBPL1, GRM5, PLCB4, BBC3, SOD1",0.460923901207223,0.197910742118267,FALSE
+"proteomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.32547,-0.963,0.454,10552,0.667,"TGFB2, PRKAA2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.342944147142896,0.175874166083451,FALSE
+"proteomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25705,0.724,0.848,3346,1,"IMPA2, INPP4B, PIK3CD, PIP4K2C, ALDH6A1, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1, ISYNA1, INPP5B, INPP5A, PIP4K2A, PI4KB, SYNJ2, PLCB3",0.0716041477432862,0,FALSE
+"proteomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.20113,0.566,0.981,2750,1,"FBP1, PIK3CD, HK1, FBP2, PTPRF, IRS1, PDPK1, KRAS, NRAS, PRKCZ, PYGB, PRKCI, EXOC7, MKNK1, PIK3R2, HK2, PIK3CA, PTPN1, PPP1R3D, IKBKB, PRKAR1B, HRAS, EIF4EBP1, MAPK3, RHEB, CBLB, GRB2, RPS6KB2, SOS2, PRKAB2, PYGL, GYS1",0.0083309926200515,0,FALSE
+"proteomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50265,-1.47,0.067,10060,0.64,"ICOSLG, TGFB1, CD40, CCR10, CCR9",1.17392519729917,0.193820026016113,FALSE
+"proteomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27492,0.779,0.769,2561,1,"SPRY2, LIFR, PIK3CD, EP300, PTPN6, STAT2, IL13RA1, IFNGR1, CCND1, IRF9, STAT1, OSMR, STAT6, SPRY1, CREBBP, PIK3R2, JAK1, PIAS3, PIK3CA, STAT3, CBLB, GRB2, SOS2",0.114073660198569,0,FALSE
+"proteomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.37967,1.06,0.326,2883,0.765,"ITGB2, PTGS2, MAPK12, MAPK13, MYD88, PTPN6, IFNGR1, STAT1, ITGA4, TRAF6, MARCKSL1, JAK1, MAPK3, NFKBIA, MAPK14, C3, MAPK1, IL1B",0.486782399932061,0.116338564846382,FALSE
+"proteomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.50535,1.4,0.109,809,0.575,"CLDN18, CLDN4, CLDN7, RAC2, CDH5, ITGAL, ITGB2, CLDN3, F11R, CLDN6, CTNND1, ACTN3, CTNNA1, JAM2, MAPK12, CTNNA2, CTNNB1, PIK3CD, MAPK13",0.962573502059376,0.24033215531037,FALSE
+"proteomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.6513,-1.97,0.00756,7847,0.296,"ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, YOD1, ALDH2, ALDH7A1, NAA80",2.12147820449879,0.528708288941061,FALSE
+"proteomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",-0.568,-1.67,0.0422,10332,0.518,"PLA2G6, CYP3A7",1.37468754903833,0.285670240254767,FALSE
+"proteomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",-0.22631,-0.665,0.946,9590,0.989,"GNAI1, ITPR1, PLCB2, GRM5, PLCB4, PLA2G6, PPP1R17",0.0241088635982073,0.0048037084028206,FALSE
+"proteomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.24302,0.676,0.913,2407,1,"EP300, PPP3R1, PPP3CA, PPP3CB, PPP3R2, KRAS, NRAS, RPS6KA1, CREBBP, RPS6KA6, PLCB1, RPS6KA2, HRAS, MAPK3, CAMK2D",0.039529222465701,0,FALSE
+"proteomics","Log2FC","KEGG_LYSINE_DEGRADATION",-0.35898,-1.05,0.348,10138,0.634,"TMLHE, PIPOX, ALDH2, ALDH7A1, AADAT, BBOX1",0.458420756053419,0.197910742118267,FALSE
+"proteomics","Log2FC","KEGG_LYSOSOME",0.25134,0.697,0.881,1651,1,"CTSE, CTSH, AP1M2, CTSS, ACP5, LAMP3, NEU1, NPC2, NAPSA, CTSA, SLC11A2, GM2A, AP1B1, AP1S1, FUCA1, SGSH",0.0550240915879521,0,FALSE
+"proteomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",-0.30167,-0.869,0.617,9929,0.76,"TGFB3, DUSP16, MAPK8, FLNC, DDIT3, MKNK2, FGFR1, TGFB1, MAP2K5, PLA2G6, MAP2K6, MAPK11, MYC, NFKB2, TGFB2, ATF4, RELB, IL1A, CACNA2D2, DUSP4, CACNA2D1, MEF2C, FGF13, FGF2, RASGRP2, PDGFRA",0.209714835966758,0.119186407719209,FALSE
+"proteomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.73187,-2.15,0,9747,0.299,"HNF1A, HNF4A, NEUROD1, GCK, MNX1, PAX6",Inf,0.52432881167557,FALSE
+"proteomics","Log2FC","KEGG_MELANOGENESIS",0.30698,0.863,0.613,3523,0.99,"GNAO1, TYR, CTNNB1, WNT5B, EP300, LEF1, KRAS, NRAS, WNT11, DVL1, CREBBP, CREB3L2, CREB3L1, PLCB1, HRAS, MAPK3, CAMK2D, WNT5A, TCF7L1, MAPK1, GNAI2, DVL3, GNAI3, ADCY9, CAMK2B, PLCB3, ADCY5, CREB1, PRKCG",0.212539525481585,0.00436480540245009,FALSE
+"proteomics","Log2FC","KEGG_MELANOMA",-0.43,-1.27,0.17,10540,0.538,"CDK6, FGF13, FGF2, PDGFRA",0.769551078621726,0.269217724333611,FALSE
+"proteomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42413,-1.23,0.212,10663,0.521,"AKR1C1, GSTM2, AKR1C3, AKR1C2, GSTA4, ALDH3A1, CYP3A7",0.673664139071249,0.283162276700476,FALSE
+"proteomics","Log2FC","KEGG_MISMATCH_REPAIR",0.43847,1.21,0.205,4177,0.592,"PCNA, LIG1, MLH3, RFC5, POLD4, EXO1, RFC2, RFC3, RFC1, RPA3, POLD3, RFC4",0.688246138944246,0.22767829327708,FALSE
+"proteomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.42655,1.22,0.195,2845,0.62,"VEGFA, VEGFC, PIK3CD, CAB39, PDPK1, RPS6KA1, PIK3R2, RPS6KA6, HIF1A, PIK3CA, RPS6KA2, EIF4EBP1, MAPK3, RHEB, RPS6KB2, RICTOR, RPS6KA3, MAPK1",0.709965388637482,0.207608310501746,FALSE
+"proteomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.48135,1.36,0.116,2561,0.636,"RAC2, ITGAL, ITGB2, LCK, RAET1L, ULBP2, NFATC4, SH3BP2, ICAM2, PIK3CD, RAC3, PTPN6, PPP3R1, VAV1, LCP2, PPP3CA, VAV2, IFNGR1, PPP3CB, PPP3R2, KRAS, NRAS, PTK2B, ICAM1, NFATC1, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, NFATC3, NFATC2, SOS2",0.935542010773082,0.196542884351586,FALSE
+"proteomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.21798,-0.625,0.932,8815,1,"TACR1, LEPR, F2R, P2RY11, CTSG, GRM5, PRSS1",0.0305840876460186,0,FALSE
+"proteomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31617,0.88,0.593,2672,0.962,"ARHGDIB, BCL2, TP73, PRKCD, ZNF274, MAPK12, PIK3CD, MAPK13, IRS1, GAB1, PDPK1, MAP3K5, TRAF6, KRAS, NRAS, RPS6KA4, MAP3K1, RPS6KA1, MAGED1, RHOA, PIK3R2, RPS6KA6, TP53, RAC1, NTRK2, PIK3CA, IKBKB, RPS6KA2, HRAS, MAPK3, CAMK2D, NFKBIA, GRB2, SOS2, FRS2, MAPK14, SORT1",0.226945306635737,0.0168249279621871,FALSE
+"proteomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48857,-1.4,0.108,9003,0.675,"NMNAT3, NAMPT, NNT, NT5C, CD38, BST1, NNMT",0.96657624451305,0.170696227168975,FALSE
+"proteomics","Log2FC","KEGG_NITROGEN_METABOLISM",-0.39831,-1.16,0.263,9727,0.564,"CA14, CA2, CA12, CPS1, CA8",0.580044251510242,0.248720896016658,FALSE
+"proteomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43448,1.23,0.191,2883,0.615,"CASP5, CXCL1, MAPK12, TRIP6, MAPK13, CASP1, TRAF6, IL18, IKBKB, MAPK3, NAIP, NFKBIA, TAB3, MAPK14, CASP8, CCL13, MAPK1, IL1B",0.718966632752272,0.211124884224583,FALSE
+"proteomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.71762,-2.13,0.00549,9253,0.171,"NHEJ1, PRKDC, RAD50, MRE11, POLL",2.26042765554991,0.767003889607846,TRUE
+"proteomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.41063,1.15,0.269,2596,0.694,"RXRA, RXRG, TGFA, ERBB2, PIK3CD, EGFR, CDK4, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, CDKN2A",0.570247719997592,0.158640529545145,FALSE
+"proteomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.34018,0.956,0.495,3178,0.924,"DTX3L, EP300, JAG1, NOTCH3, NCOR2, DVL1, CREBBP, DTX2, CTBP1, NUMB, HDAC1, MAML3, DVL3, RBPJ, JAG2",0.305394801066431,0.0343280287798933,FALSE
+"proteomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.17811,-0.529,0.992,1956,0.991,"ERCC5, PCNA, RAD23B, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, CUL4A, POLE4, POLD3, RFC4, RBX1, CETN2, POLE3, DDB1, MNAT1, POLD1, ERCC6, RAD23A, ERCC4, RPA2, POLE2, POLD2, RPA1, CDK7, GTF2H5, ERCC3, DDB2, CUL4B, GTF2H3, ERCC2, CCNH, GTF2H4, GTF2H1, GTF2H2, ERCC1, ERCC8, XPC, XPA",0.00348832784582135,0.00392634551472468,FALSE
+"proteomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.47511,1.35,0.116,836,0.579,"MAN1C1, MGAT4A, ST6GAL1, B4GALT1, FUT8",0.935542010773082,0.237321436272564,FALSE
+"proteomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",-0.37643,-1.13,0.289,9870,0.552,"CNGB1, PDE1C",0.539102157243452,0.258060922270801,FALSE
+"proteomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53605,-1.57,0.0683,8075,0.503,"MTHFD1L, ATIC, MTHFD2, MTHFS, MTFMT, TYMS, MTHFR, GART, ALDH1L1",1.16557929631847,0.298432014944073,FALSE
+"proteomics","Log2FC","KEGG_OOCYTE_MEIOSIS",0.19709,0.561,0.973,3300,1,"MAPK12, PPP3R1, ANAPC11, PPP3CA, AR, AURKA, PPP3CB, PPP2R5E, CCNB1, PPP3R2, PPP2R5B, BUB1, RPS6KA1, RPS6KA6, RPS6KA2, MAPK3, CAMK2D, IGF1R, RPS6KA3, MAPK1, BTRC, YWHAB, ADCY9, PKMYT1, CAMK2B",0.0118871597316481,0,FALSE
+"proteomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.2091,-0.614,0.942,7256,1,"FUCA2, MAN2B1, HEXB, MAN2B2, AGA, MAN2C1, HEXA",0.0259490972071227,0,FALSE
+"proteomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.46085,-1.37,0.135,7298,0.559,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, COX15, ATP6V1A, COX4I1, SDHC, COX6B1, COX6A1, NDUFV1, UQCRC1, ATP6V1B2, COX7A2, NDUFA6, NDUFC1, PPA1, ATP6V0A2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, NDUFA11, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, ATP5MG, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5ME, ATP5MC2, COX11",0.869666231504994,0.252588192113577,FALSE
+"proteomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.59998,1.71,0.023,1847,0.775,"GCNT3, GALNT3, GALNT12, GALNT6, ST6GALNAC1, GALNT8, GALNT13, GALNT7, B4GALT5, GALNT2, GALNT15, GALNT5, C1GALT1C1, GALNT4, ST3GAL1",1.63827216398241,0.11069829749369,FALSE
+"proteomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.29693,0.85,0.656,1726,1,"TP73, SERPINB5, SESN3, THBS1, CHEK2, CDK4, CCND1, RCHY1, CCNB1, CDKN1A, EI24",0.18309616062434,0,FALSE
+"proteomics","Log2FC","KEGG_PANCREATIC_CANCER",0.39919,1.12,0.274,2405,0.698,"RAC2, VEGFA, TGFA, ERBB2, VEGFC, PIK3CD, RAC3, EGFR, CDK4, RALB, CCND1, STAT1, KRAS, PIK3R2, TP53, JAK1, RAC1, PIK3CA, STAT3, IKBKB, MAPK3",0.562249437179612,0.156144577376839,FALSE
+"proteomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.26633,0.732,0.805,2657,1,"BCAT2, PANK1, DPYD",0.0942041196321315,0,FALSE
+"proteomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.47609,-1.38,0.103,7298,0.666,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, UBE2J2, COX4I1, SLC18A1, SDHC, COX6B1, COX6A1, CYCS, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, UBE2G2, UBE2G1, HTRA2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, PARK7, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, UCHL1",0.987162775294828,0.176525770829699,FALSE
+"proteomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.24664,0.687,0.884,646,1,"LY96, CDH1, TUBA4A, CTNNB1",0.0535477349869269,0,FALSE
+"proteomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.24197,0.671,0.906,2654,0.996,"RAC2, BCL2, CDH1, PTGS2, VEGFA, CTNNA1, LAMC2, LAMB3, RXRA, RXRG, TRAF4, CTNNA2, CTNNB1, TGFA, ERBB2, WNT5B, VEGFC, PIK3CD, RAC3, EP300, MECOM, RARA, RUNX1, ITGA2, LAMA3, LAMA4, NCOA4, EGFR, CKS1B, CDK4, RALB, SKP2, AR, LEF1, CCND1, STAT1, TRAF6, KRAS, NRAS, CDKN1A, ITGA3, WNT11, DVL1, FLT3, MAX, RHOA, MMP2, BCR, CREBBP, PIK3R2, TP53, JAK1, RAC1, PIAS3, HIF1A, MET, SLC2A1, PIK3CA, CTBP1, STAT3, IKBKB, HRAS, MAPK3, LAMB1, WNT5A, NFKBIA, CBLB, GRB2, IGF1R, SOS2, CDKN2A, TCF7L1, HDAC1, PAX8",0.0428718023231869,0.00174066157630127,FALSE
+"proteomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39564,1.1,0.317,6667,0.698,"DCXR, UGP2, XYLB, UGDH, CRYL1, UGT2B11, UGT2B4, RPE, GUSB, AKR1B1",0.498940737782249,0.156144577376839,FALSE
+"proteomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50211,1.41,0.105,829,0.583,"ALDOB, FBP1, ALDOC, FBP2",0.978810700930062,0.234331445240986,FALSE
+"proteomics","Log2FC","KEGG_PEROXISOME",0.32858,0.936,0.506,2901,0.948,"FAR1, PXMP4, EPHX2, PEX13, MVK, ACSL4, ACOT8, ACAA1, AMACR, ACSL1, CAT, CRAT, ACOX1, SLC25A17, FAR2, SCP2, CROT, ACSL6, GSTK1, IDH2, ACOX3, ACSL5, PMVK, PEX7, NUDT12, ACSL3, ABCD3, IDH1, PXMP2",0.295849483160201,0.0231916626619338,FALSE
+"proteomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",-0.44236,-1.3,0.184,10509,0.624,"MAOB, NAA80, ALDH3A1",0.735182176990464,0.204815410317576,FALSE
+"proteomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.26615,0.746,0.809,2260,1,"IMPA2, DGKA, INPP4B, PIK3CD, PIP4K2C, CDS1, DGKH, DGKB, PIK3R2, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1",0.0920514783877277,0,FALSE
+"proteomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.41459,-1.23,0.192,8765,0.521,"BLVRA, HMBS, PPOX, EARS2, BLVRB, HMOX1, ALAS1, UROD, UROS, FECH",0.71669877129645,0.283162276700476,FALSE
+"proteomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.40642,1.15,0.269,1703,0.694,"CD36, PLTP, LPL, FADS2, FABP6, FABP2, RXRA, RXRG, SCD5, ACSL4, FABP3, APOC3, ACAA1, PDPK1, ACSL1, ACOX1, CPT2, SCP2, ACSL6, HMGCS2",0.570247719997592,0.158640529545145,FALSE
+"proteomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.44792,1.25,0.196,1638,0.608,"CYP7B1, AMACR, SCP2",0.707743928643524,0.216096420727265,FALSE
+"proteomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.32308,-0.922,0.49,9562,0.707,"RFX5, RFXAP, CD40, BLNK",0.309803919971486,0.150580586203101,FALSE
+"proteomics","Log2FC","KEGG_PRION_DISEASES",-0.62081,-1.84,0.0198,10295,0.408,"C7, SOD1, C9, NCAM1, IL1A, NCAM2, EGR1",1.70333480973847,0.38933983691012,FALSE
+"proteomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.25639,0.729,0.844,3263,1,"FZR1, MAPK12, PIK3CD, MAPK13, ANAPC11, CCNB1, KRAS, BUB1, CCNA2, RPS6KA1, PIK3R2, RPS6KA6, PIK3CA, RPS6KA2, MAPK3, IGF1R, MAPK14, RPS6KA3, MAPK1, GNAI2, GNAI3, CCNB3, ADCY9, PKMYT1",0.073657553374345,0,FALSE
+"proteomics","Log2FC","KEGG_PROPANOATE_METABOLISM",-0.26044,-0.763,0.769,10443,0.888,"ALDH2, ALDH7A1, ACSS3",0.114073660198569,0.051587034221399,FALSE
+"proteomics","Log2FC","KEGG_PROSTATE_CANCER",0.32384,0.906,0.547,2624,0.982,"BCL2, CTNNB1, TGFA, ERBB2, PIK3CD, EP300, EGFR, AR, LEF1, PDPK1, CCND1, KRAS, NRAS, CDKN1A, CREBBP, PDGFC, PIK3R2, CREB3L2, TP53, CREB3L1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, GRB2, IGF1R, SOS2, TCF7L1",0.262012673666569,0.00788851221305034,FALSE
+"proteomics","Log2FC","KEGG_PROTEASOME",0.2805,0.799,0.719,7310,0.996,"PSMB10, PSMB8, PSME2, PSME1, POMP, PSMB1, PSMB9, PSMA7, PSMA1, PSMA2, PSME3, PSMA8, PSMA3, PSMB2, PSMC6, PSMB3, PSMD7, PSME4, PSMA5, PSMB4, PSMA4, PSMD4, PSMD2, PSMB7, PSMD3, PSMD11, PSMC2, PSMC4, PSMC3, PSMC5, PSMF1, PSMD12, PSMD13, PSMA6, PSMC1, PSMB6, PSMD14, PSMD6, PSMD8, PSMD1, SEM1",0.143271109617117,0.00174066157630127,FALSE
+"proteomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.34994,-1.03,0.366,7823,0.626,"SEC61B, IMMP2L, SEC11C, SEC63, IMMP1L, SEC61A2",0.436518914605589,0.20342566678957,FALSE
+"proteomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.28081,0.789,0.741,3930,1,"ATP1A2, GLUD2, AQP1, SLC38A3, ATP1A3, ATP1A4, ATP1A1, SLC9A3, PCK1, ATP1B1",0.130181792020672,0,FALSE
+"proteomics","Log2FC","KEGG_PURINE_METABOLISM",-0.26075,-0.764,0.767,7632,0.902,"PRIM2, PDE4D, POLA1, POLR3C, HPRT1, POLR2E, POLR3A, POLR3H, PDE8A, ENTPD4, GMPR2, POLA2, POLR2H, NUDT9, PNPT1, ATIC, NME2, ADCY3, ADCY8, PAPSS2, AK5, NUDT2, POLR3GL, GDA, POLR1E, GMPS, RRM2B, ADCY10, NPR2, GART, PFAS, NT5C, NME4, NUDT5, PDE3A, ADCY6, ENTPD1, PDE4A, NME1, NPR1, PDE1C, ENTPD8",0.115204636051019,0.0447934624580583,FALSE
+"proteomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.20888,-0.611,0.973,7564,0.999,"POLR2A, AK3, PRIM2, DHODH, DCTD, POLA1, POLR3C, POLR2E, POLR3A, POLR3H, ENTPD4, POLA2, POLR2H, PNPT1, NME2, DTYMK, NUDT2, TYMS, POLR3GL, POLR1E, CAD, RRM2B, DUT, UCK2, NT5C, UMPS, NME4, TXNRD1, ENTPD1, CTPS1, NME1, ENTPD8",0.0118871597316481,0.000434511774017692,FALSE
+"proteomics","Log2FC","KEGG_PYRUVATE_METABOLISM",-0.33889,-1.01,0.38,7380,0.62,"ACYP2, GRHPR, ACACA, PDHB, ALDH9A1, ME2, ALDH1B1, PDHA1, ACAT1, ALDH3A2, GLO1, PCK2, HAGH, ME3, ALDH2, ALDH7A1",0.42021640338319,0.207608310501746,FALSE
+"proteomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.26341,0.738,0.83,1559,1,"ITGB6, RAC2, ITGAL, PAK5, PAK6, ITGB8, ITGB2, ACTN3, ITGB4, BAIAP2, SCIN, MYH14, PIK3CD, PIP4K2C, SLC9A1, RAC3, VAV1, GSN, ITGA2, ITGA11, EGFR, SSH3, VAV2, FGD3, ITGA4, KRAS, NRAS",0.0809219076239261,0,FALSE
+"proteomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.43145,-1.22,0.195,7210,0.5,"PIK3R4, ATG4B, ULK1, ATG5, PIK3C3, GABARAPL1, ATG3, ATG7, ULK3, PRKAA2",0.709965388637482,0.301029995663981,FALSE
+"proteomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3892,1.1,0.324,2561,0.698,"PAK5, PAK6, VEGFA, TGFA, VEGFC, PIK3CD, EP300, GAB1, KRAS, NRAS, CREBBP, PIK3R2, RAC1, HIF1A, MET, SLC2A1, PIK3CA, HRAS, MAPK3, GRB2, SOS2",0.489454989793388,0.156144577376839,FALSE
+"proteomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.32703,-0.923,0.523,9197,0.719,"NLN, AGT, CTSG, ACE2",0.281498311132726,0.143271109617117,FALSE
+"proteomics","Log2FC","KEGG_RETINOL_METABOLISM",-0.40251,-1.17,0.232,10576,0.565,"ALDH1A2, ALDH1A1, CYP3A7",0.6345120151091,0.247951552180562,FALSE
+"proteomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.46483,1.31,0.151,593,0.557,"ACP5, MTMR7, TYR",0.821023052706831,0.254144804826271,FALSE
+"proteomics","Log2FC","KEGG_RIBOSOME",-0.54955,-1.62,0.0466,6763,0.472,"RPSA, RPS16, RPS26, MRPL13, RPL13, RPL11, RPS25, RPL37A, RPL35, RPS4X, RPL27, RPS21, RPS28, RPS27L, RPS15A, RPS2, RPL14, FAU, RPL23, RPL7A, RPL29, RPS29, RPL21, RPL5, RPL34, RPL22, RPS9, RPS3, RPS18, RPL17, RPL15, RPL8, RPL18A, RPS3A, RPS12, RPL28, RPS11, RPL36, RPS17, RPL36A, RPL36AL, RPL3, RPL13A, RPL32, RPL26, RPL27A, RPS8, RPL10A, RPS7, RPS24, RPL7, RPS23, RPL31, RPL9, RPS13, RPL35A, RPL18, RPL19, RPL24, RSL24D1, RPL4, RPS20, RPL6, RPL38, RPS6, RPL37, RPL26L1, RPS4Y1",1.33161408331,0.326058001365912,FALSE
+"proteomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21434,0.604,0.954,1713,1,"ISG15, MAPK12, MAPK13, CASP10, DDX58, DHX58, TRAF6, MAP3K1",0.0204516252959049,0,FALSE
+"proteomics","Log2FC","KEGG_RNA_DEGRADATION",-0.43669,-1.29,0.158,7190,0.609,"TTC37, EXOSC3, EXOSC2, EXOSC4, DIS3, EXOSC9, EXOSC5, EXOSC7, LSM2, PNPT1, EXOSC10, EXOSC8, LSM1, EXOSC1, MTREX, ENO3, HSPD1, HSPA9, PARN, TENT4A, DCP2, MPHOSPH6, DCPS, DCP1B",0.801342913045577,0.215382707367125,FALSE
+"proteomics","Log2FC","KEGG_RNA_POLYMERASE",-0.42301,-1.24,0.195,5911,0.545,"POLR3F, POLR1B, POLR2D, POLR3K, POLR2B, POLR2G, POLR2C, POLR1A, POLR3B, POLR1C, POLR1D, POLR3D, POLR2L, POLR2I, POLR2A, POLR3C, POLR2E, POLR3A, POLR3H, POLR2H, POLR3GL, POLR1E",0.709965388637482,0.263603497723358,FALSE
+"proteomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",0.26182,0.75,0.809,2085,1,"GGT5, CTH, METTL6, GGT7",0.0920514783877277,0,FALSE
+"proteomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.31583,0.88,0.593,2488,0.962,"BCL2, PTGS2, LAMC2, LAMB3, RXRA, RXRG, TRAF4, PIK3CD, ITGA2, LAMA3, LAMA4, CKS1B, CDK4, SKP2, CCND1, TRAF6, ITGA3, MAX, PIK3R2, TP53, PIAS3, PIK3CA, IKBKB, LAMB1, NFKBIA",0.226945306635737,0.0168249279621871,FALSE
+"proteomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.25505,0.718,0.837,3653,1,"VAMP8, VAMP4, TSNARE1, BET1L, STX17, SNAP47, STX3, GOSR1, STX10, SNAP29, STX16, STX18, STX12, STX6, VTI1B, SNAP23",0.07727454200674,0,FALSE
+"proteomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.29469,0.817,0.689,2465,0.994,"CERK, NEU1, UGT8, SGPP2, SPTLC2, GALC, PLPP3, DEGS1, SPTLC1",0.161780778092374,0.00261361560268669,FALSE
+"proteomics","Log2FC","KEGG_SPLICEOSOME",-0.44795,-1.27,0.184,6622,0.538,"BCAS2, SNRPD1, SNRPD2, USP39, SF3A2, PRPF6, LSM3, THOC2, SNW1, SRSF6, SYF2, PQBP1, HNRNPA1, U2AF2, ACIN1, SNRPB2, MAGOHB, SRSF7, PRPF40A, HSPA8, HNRNPC, SNRPC, PPIL1, THOC1, RBM25, CTNNBL1, ZMAT2, SNRNP200, PRPF38B, HNRNPK, PRPF31, PPIH, HNRNPM, EIF4A3, DDX46, DDX39B, HNRNPA3, SF3A3, SRSF9, U2AF1, SRSF1, DDX23, SRSF4, SNRPA, SNRNP27, EFTUD2, SRSF8, PRPF38A, TRA2B, SNRPD3, DHX16, PPIE, SNRPF, SRSF3, LSM2, ALYREF, RBM8A, RBM17, SRSF2, SF3B4, TCERG1, RBMX, PRPF8, CDC40, U2SURP, SMNDC1, WBP11, RBM22, SNRNP40, SLU7, PRPF18, TRA2A, BUD31, SNU13, TXNL4A, CHERP, HNRNPU",0.735182176990464,0.269217724333611,FALSE
+"proteomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44846,1.24,0.195,2989,0.612,"HK1, SI, PYGB, PGM1, HK2, GAA, PGM2, AGL, PYGL, GYS1, UGP2, MGAM, PGM2L1",0.709965388637482,0.213248577854439,FALSE
+"proteomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.72045,2.02,0.00637,2290,0.554,"DHCR24, MSMO1, FDFT1, CYP27B1, DHCR7, SC5D, SQLE, NSDHL, HSD17B7, CYP51A1, LSS",2.19586056766465,0.25649023527157,FALSE
+"proteomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44063,-1.31,0.15,10468,0.637,"AKR1D1, CYP21A2, AKR1C1, AKR1C3, AKR1C2, CYP3A7",0.823908740944319,0.19586056766465,FALSE
+"proteomics","Log2FC","KEGG_SULFUR_METABOLISM",0.57977,1.61,0.0561,1903,0.604,"SULT2B1, SULT1A3, CHST12",1.25103713874384,0.218963061378868,FALSE
+"proteomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.47545,-1.37,0.141,9770,0.559,"CTSG, C7, CD40, C9, C1S",0.85078088734462,0.252588192113577,FALSE
+"proteomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.39951,1.11,0.291,89,0.706,"SCNN1A",0.536107011014093,0.151195298948196,FALSE
+"proteomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.5101,1.43,0.0917,2497,0.601,"HMGCS1, MVK, HMGCR, HMGCS2, PDSS2, PMVK, FDPS",1.03763066432998,0.22112552799726,FALSE
+"proteomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.42677,-1.27,0.174,9929,0.538,"TGFB3, THBS4, THBS3, TGFB1, SMAD2, BMPR2, MYC, INHBA, FST, ACVR2A, TGFB2, BMPR1A, INHBE",0.7594507517174,0.269217724333611,FALSE
+"proteomics","Log2FC","KEGG_THYROID_CANCER",0.56509,1.58,0.0367,2845,0.551,"CDH1, RXRA, RXRG, CTNNB1, NCOA4, LEF1, CCND1, KRAS, NRAS, TP53, HRAS, MAPK3, TCF7L1, PAX8, MAPK1",1.43533393574791,0.258848401148215,FALSE
+"proteomics","Log2FC","KEGG_TIGHT_JUNCTION",0.5679,1.55,0.0531,1947,0.569,"CLDN18, CLDN4, CLDN7, CRB3, MYH7, PRKCH, EPB41L1, CGN, CLDN3, F11R, CLDN6, TJP3, ACTN3, CTNNA1, PRKCD, JAM2, PATJ, CTNNA2, CTNNB1, MYH14, MYH7B, TJP2, LLGL2, CDK4, MAGI3, PRKCQ, CASK, KRAS, NRAS, PRKCZ, PRKCI, CTTN, PARD6G, YES1, CLDN11, EXOC3, MYL9, RHOA, EXOC4",1.27490547891853,0.244887733604929,FALSE
+"proteomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.24732,0.693,0.877,2883,1,"LY96, IRF5, MAPK12, PIK3CD, MAPK13, MYD88, STAT1, TRAF6, PIK3R2, RAC1, PIK3CA, IKBKB, MAPK3, NFKBIA, IKBKE, MAPK14, CASP8, MAPK1, IL1B",0.0570004066339595,0,FALSE
+"proteomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",-0.38666,-1.12,0.269,10040,0.553,"WARS2, ALDH2, MAOB, ALDH7A1, AADAT, KYNU",0.570247719997592,0.257274868695302,FALSE
+"proteomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",-0.31589,-0.937,0.499,10063,0.704,"MAPK8, GCK, SOCS2, SOCS4",0.30189945437661,0.152427340857888,FALSE
+"proteomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.44767,1.26,0.184,1073,0.604,"CPE, PTPRN2, ICA1",0.735182176990464,0.218963061378868,FALSE
+"proteomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.29251,0.817,0.703,2304,0.994,"ADH4, ADH7, TYR, HGD, ALDH1A3, ALDH3B1, METTL6, ADH1C, COMT, TAT, MIF",0.153044674980176,0.00261361560268669,FALSE
+"proteomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.50774,1.41,0.105,2664,0.583,"PAK5, PAK6, LCK, CARD11, MAPK12, NFATC4, PIK3CD, MAPK13, PTPN6, PPP3R1, VAV1, LCP2, CDK4, PPP3CA, VAV2, PDPK1, PPP3CB, PPP3R2, PRKCQ, KRAS, NRAS, RHOA, NFATC1, PTPRC, PIK3R2, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, VAV3, GRB2, NFATC3, NFATC2, SOS2, TEC, MAPK14",0.978810700930062,0.234331445240986,FALSE
+"proteomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18021,0.514,0.992,2223,1,"FZR1, UBE2C, UBA7, UBE2E3, ANAPC11, TRIM37, SKP2, RCHY1, MGRN1, UBOX5, UBE2L6, KEAP1, TRAF6, MAP3K1, UBE2O, ITCH, UBA6, PIAS3, BRCA1",0.00348832784582135,0,FALSE
+"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.33808,-0.986,0.445,7753,0.654,"PDHB, PDHA1, LARS2, BCAT1",0.351639989019068,0.184422251675733,FALSE
+"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.25067,0.702,0.903,2361,1,"ABAT, HMGCS1, ALDH6A1, ACAD8, ACAA1, BCAT2, HMGCS2, MCCC1, HIBADH, ACADM, DBT, ACADS",0.0443122496864942,0,FALSE
+"proteomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.285,-0.854,0.598,9514,0.777,"NPR2, ITPR1, PLCB2, ARHGEF11, ARHGEF1, PLCB4, PLA2G6, ADCY6, NPR1, CALD1, KCNMA1, PPP1R14A",0.223298816011589,0.109578981199086,FALSE
+"proteomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.2868,0.808,0.735,2159,0.989,"ARHGDIB, AQP3, DYNLL2, RAB11B, CREB3L2, CREB3L1, RAB11A",0.133712660915805,0.0048037084028206,FALSE
+"proteomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.53564,1.51,0.0619,2664,0.569,"RAC2, PTGS2, VEGFA, HSPB1, MAPK12, NOS3, NFATC4, PIK3CD, MAPK13, PLA2G12A, RAC3, PPP3R1, PPP3CA, PLA2G2A, PPP3CB, PPP3R2, KRAS, NRAS, NFATC1, PIK3R2, MAPKAPK3, RAC1, PIK3CA, HRAS, MAPK3, NFATC3, NFATC2, MAPK14",1.20830935097988,0.244887733604929,FALSE
+"proteomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.14569,0.405,1,1695,1,"TJP2, ERO1A, PDIA4, KDELR3",0,0,FALSE
+"proteomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.40292,1.12,0.291,1355,0.698,"RAC2, MYH7, ITGAL, ITGB2, MYH14, MYH7B, RAC3, SGCG, CCND1",0.536107011014093,0.156144577376839,FALSE
+"proteomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.29792,0.841,0.662,2624,1,"RAC2, VANGL2, SFRP4, CTNNB1, NFATC4, WNT5B, DAAM1, RAC3, EP300, PPP3R1, CSNK1A1, TBL1XR1, PPP3CA, LEF1, CCND1, PPP3CB, PPP2R5E, PPP3R2, LRP5, PPP2R5B, SENP2, DKK1, WNT11, DVL1, RHOA, NFATC1, CREBBP, TP53, PLCB1, RAC1, CHD8, CTBP1, CSNK1E, CAMK2D, WNT5A, NFATC3, NFATC2, TCF7L1",0.1791420105603,0,FALSE
+"metabolomics","Log2FC","alpha amino acids",-0.62759,-1.46,0.0709,172,0.169,"sarcosine, phosphocreatine, creatinine, dimethylglycine, citrulline, ornithine, homocysteine",1.14935376481693,0.772113295386326,FALSE
+"metabolomics","Log2FC","acyl carnitines",-0.61528,-1.41,0.119,202,0.105,"hexanoylcarnitine, malonylcarnitine, propionylcarnitine",0.924453038607469,0.978810700930062,FALSE
diff --git a/Examples/Fig3/GSEA/GSEA_venn_diagram.pdf b/Examples/Fig3/GSEA/GSEA_venn_diagram.pdf
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index 0000000..397fb70
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diff --git a/Examples/Fig4/.DS_Store b/Examples/Fig4/.DS_Store
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diff --git a/Examples/Fig4/DMEA/DMEA_correlation_matrix.pdf b/Examples/Fig4/DMEA/DMEA_correlation_matrix.pdf
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diff --git a/Examples/Fig4/DMEA/DMEA_dot_plot.pdf b/Examples/Fig4/DMEA/DMEA_dot_plot.pdf
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index 0000000..49f005e
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diff --git a/Examples/Fig4/DMEA/DMEA_interactive_network.graph.html b/Examples/Fig4/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
index 0000000..03a3df9
--- /dev/null
+++ b/Examples/Fig4/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNFQxNDo0MTowNCswMTowMDwveG1wOk1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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-347a477a69f2bd925ae7" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/Fig4/DMEA/DMEA_mean_results.csv b/Examples/Fig4/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..5ba83f4
--- /dev/null
+++ b/Examples/Fig4/DMEA/DMEA_mean_results.csv
@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"acetylcholine receptor agonist",1.71,0.330454232837166,0.0392238747624452,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.21703877368553
+"MDM inhibitor",1.62,0.681102048154313,0.188660309188708,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.602261756256262
+"ATPase inhibitor",1.61333333333333,0.39272551907577,0.0112250442412866,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.135870453931087
+"sterol demethylase inhibitor",1.59,0.550545184340032,0.00214591881540417,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.0593704205595154
+"PLK inhibitor",1.584,0.68851143781349,0.000626169232500466,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.0346620027944518
+"DNA inhibitor",1.28666666666667,0.0750555349946514,0.125629313988104,"transcriptomics, proteomics, metabolomics",3,0,"",0.489501665952806
+"androgen receptor antagonist",1.21966666666667,0.693870545082679,0.0772833971310988,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.377324821287129
+"CC chemokine receptor antagonist",1.18666666666667,0.361155552820849,0.19603359140473,"transcriptomics, proteomics, metabolomics",3,0,"",0.602621780984912
+"estrogen receptor agonist",1.16533333333333,0.247033061215161,0.246748051769973,"transcriptomics, proteomics, metabolomics",3,0,"",0.640002759278367
+"progesterone receptor agonist",1.05566666666667,0.396706860708677,0.32951191602721,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858
+"antioxidant",0.987,0.170402464770906,0.55992464618085,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842
+"tubulin polymerization inhibitor",0.964,0.28479466287134,0.55518712824729,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842
+"Aurora kinase inhibitor",0.962666666666667,0.376432375511636,0.508295283552775,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842
+"dopamine receptor antagonist",0.957,0.335214856472681,0.550338006771623,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842
+"protein synthesis inhibitor",0.954333333333333,0.161202770861215,0.60457277403347,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117
+"serotonin receptor agonist",0.757,1.32189523034165,0.0914955488402172,"transcriptomics, proteomics, metabolomics",3,0,"",0.399691081775686
+"bacterial 50S ribosomal subunit inhibitor",0.701333333333333,1.41005862762274,0.0460458802029331,"transcriptomics, proteomics, metabolomics",3,0,"",0.238863003552715
+"glucocorticoid receptor agonist",0.638,1.10047444313805,0.389753605653181,"transcriptomics, proteomics, metabolomics",3,0,"",0.718878872649201
+"DNA polymerase inhibitor",0.544333333333333,1.06111560790205,0.520318935072838,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842
+"mTOR inhibitor",0.489666666666667,0.989110880201676,0.645230401470049,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117
+"bacterial DNA gyrase inhibitor",0.489,0.972143507924627,0.646573085186216,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117
+"HMGCR inhibitor",0.483333333333333,1.41736845362571,0.135645039962826,"transcriptomics, proteomics, metabolomics",3,0,"",0.489501665952806
+"HCV inhibitor",0.436666666666667,1.7931629410997,0.015096842163348,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087
+"growth factor receptor inhibitor",0.426666666666667,1.49901078492896,0.135292699781582,"transcriptomics, proteomics, metabolomics",3,0,"",0.489501665952806
+"ribonucleotide reductase inhibitor",0.412666666666667,1.23362933384925,0.376560550554142,"transcriptomics, proteomics, metabolomics",3,0,"",0.710330129454404
+"serotonin receptor antagonist",0.393,1.09220373557318,0.627988593244907,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117
+"JAK inhibitor",0.370333333333333,1.14195461089018,0.547577538955838,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842
+"PI3K inhibitor",0.370333333333333,0.728522706120635,0.959364387548974,"transcriptomics, proteomics, metabolomics",3,0,"",0.99320518653544
+"FLT3 inhibitor",0.34,1.01956068970905,0.72737145097148,"transcriptomics, proteomics, metabolomics",3,0,"",0.850307470853983
+"estrogen receptor antagonist",0.334666666666667,1.12383821492835,0.582820721885315,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117
+"adrenergic receptor antagonist",0.33,0.806980173238475,0.930447000027383,"transcriptomics, proteomics, metabolomics",3,0,"",0.990091038490677
+"FGFR inhibitor",0.327333333333333,1.19305546113051,0.475668442774605,"transcriptomics, proteomics, metabolomics",3,0,"",0.774127073535142
+"topoisomerase inhibitor",0.191666666666667,1.43556899288517,0.219867894895788,"transcriptomics, proteomics, metabolomics",3,0,"",0.608301175878347
+"BCL inhibitor",0.172666666666667,1.1109677463065,0.696863742644651,"transcriptomics, proteomics, metabolomics",3,0,"",0.838256386079797
+"microtubule inhibitor",0.170666666666667,0.764280271453695,0.990984682883397,"transcriptomics, proteomics, metabolomics",3,0,"",0.998303322165083
+"bromodomain inhibitor",0.156666666666667,1.24599250934078,0.505326341211283,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842
+"opioid receptor agonist",0.098,1.50011732874466,0.125001127585286,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.489501665952806
+"phosphatase inhibitor",0.0383333333333333,1.19612053461737,0.593922201329678,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117
+"benzodiazepine receptor agonist",-0.127,1.27227630646806,0.451413327845409,"transcriptomics, proteomics, metabolomics",3,0,"",0.749346124223379
+"PARP inhibitor",-0.135666666666667,1.33507165850127,0.347580011944954,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858
+"DNA synthesis inhibitor",-0.141333333333333,0.823812074039543,0.967222472332557,"transcriptomics, proteomics, metabolomics",3,0,"",0.99320518653544
+"PDGFR tyrosine kinase receptor inhibitor",-0.147,1.31258409254417,0.370423346343372,"transcriptomics, proteomics, metabolomics",3,0,"",0.710330129454404
+"calcium channel blocker",-0.151333333333333,0.696685246961161,0.998303322165083,"transcriptomics, proteomics, metabolomics",3,0,"",0.998303322165083
+"Abl kinase inhibitor",-0.159666666666667,1.27335082885014,0.412677026819624,"transcriptomics, proteomics, metabolomics",3,0,"",0.728508511492598
+"tyrosine kinase inhibitor",-0.245,0.993844555249965,0.826821084410066,"transcriptomics, proteomics, metabolomics",3,0,"",0.915146790059076
+"CDK inhibitor",-0.249,1.08681323142479,0.626826576582264,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117
+"VEGFR inhibitor",-0.259,1.26753027577254,0.430083338110088,"transcriptomics, proteomics, metabolomics",3,0,"",0.728508511492598
+"p38 MAPK inhibitor",-0.276666666666667,1.34886371933318,0.337110066408449,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858
+"potassium channel blocker",-0.277666666666667,1.11229777188185,0.637553812478839,"transcriptomics, proteomics, metabolomics",3,0,"",0.789199501036117
+"protein tyrosine kinase inhibitor",-0.284,1.01960629656745,0.784618613149266,"transcriptomics, proteomics, metabolomics",3,0,"",0.904490901269293
+"KIT inhibitor",-0.303666666666667,1.33006403354626,0.302639275105415,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858
+"retinoid receptor agonist",-0.314333333333333,0.918232178336903,0.879548811247694,"transcriptomics, proteomics, metabolomics",3,0,"",0.948085082254007
+"NFkB pathway inhibitor",-0.317666666666667,0.767009995588932,0.9692725314382,"transcriptomics, proteomics, metabolomics",3,0,"",0.99320518653544
+"PPAR receptor agonist",-0.336,1.45878990947977,0.175662896954226,"transcriptomics, proteomics, metabolomics",3,0,"",0.583200817888031
+"DNA alkylating agent",-0.336333333333333,0.940261842963615,0.82693987053531,"transcriptomics, proteomics, metabolomics",3,0,"",0.915146790059076
+"thymidylate synthase inhibitor",-0.346666666666667,1.47571451620337,0.153259941840201,"transcriptomics, proteomics, metabolomics",3,0,"",0.530023965530695
+"cyclooxygenase inhibitor",-0.392666666666667,0.890733592794913,0.859987268405275,"transcriptomics, proteomics, metabolomics",3,0,"",0.939196622074182
+"AP inhibitor",-0.406666666666667,1.01398685067082,0.715613413756915,"transcriptomics, proteomics, metabolomics",3,0,"",0.848513047740342
+"HSP inhibitor",-0.464,1.0904292732681,0.559753358803866,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842
+"sodium channel blocker",-0.485666666666667,0.855131763726113,0.80245922597919,"transcriptomics, proteomics, metabolomics",3,0,"",0.912385147346203
+"RET tyrosine kinase inhibitor",-0.51,1.7516849031718,0.0180069276294212,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087
+"TGF beta receptor inhibitor",-0.524,1.11774907738723,0.424146685687652,"transcriptomics, proteomics, metabolomics",3,0,"",0.728508511492598
+"histamine receptor antagonist",-0.526666666666667,1.24460167657501,0.283848312021223,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858
+"glutamate receptor antagonist",-0.557,1.21129558737742,0.30051864145804,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858
+"DNA methyltransferase inhibitor",-0.576666666666667,1.64591413303773,0.0231385942075001,"transcriptomics, proteomics, metabolomics",3,0,"",0.137478890683736
+"Bcr.Abl kinase inhibitor",-0.599333333333333,1.18000056497162,0.244003437916364,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.640002759278367
+"AKT inhibitor",-0.668,1.15388560958182,0.20628917647822,"transcriptomics, proteomics, metabolomics",3,0,"",0.608301175878347
+"RAF inhibitor",-0.73,1.57101877773628,0.0231892104767748,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.137478890683736
+"adenosine receptor antagonist",-0.878333333333333,1.45108867176797,0.013547386796645,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087
+"MEK inhibitor",-0.9,0.491939020611295,0.537094488964896,"transcriptomics, proteomics, metabolomics",3,0,"",0.774562427216842
+"glycogen synthase kinase inhibitor",-1.01466666666667,0.40656774753211,0.344080244798991,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858
+"ALK tyrosine kinase receptor inhibitor",-1.037,0.280957292128181,0.41251678411073,"transcriptomics, proteomics, metabolomics",3,0,"",0.728508511492598
+"adrenergic receptor agonist",-1.06933333333333,0.277752287719351,0.358414507958658,"transcriptomics, proteomics, metabolomics",3,0,"",0.708295337156395
+"src inhibitor",-1.073,0.387113678394345,0.330624333722932,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858
+"acetylcholine receptor antagonist",-1.07966666666667,0.608601949827088,0.215506210639317,"transcriptomics, proteomics, metabolomics",3,1,"transcriptomics",0.608301175878347
+"cytochrome P450 inhibitor",-1.13,0.0556776436283002,0.340321314694418,"transcriptomics, proteomics, metabolomics",3,0,"",0.703637585156858
+"vitamin D receptor agonist",-1.31,0.3278719262151,0.0883367361148128,"transcriptomics, proteomics, metabolomics",3,0,"",0.399691081775686
+"proteasome inhibitor",-1.43633333333333,0.484758015233718,0.0134619947838327,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087
+"EGFR inhibitor",-1.46666666666667,0.363501490139082,0.0156625955600064,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087
+"phosphodiesterase inhibitor",-1.47333333333333,0.183393929379719,0.0218373546944777,"transcriptomics, proteomics, metabolomics",3,0,"",0.137478890683736
+"MET inhibitor",-1.47933333333333,0.575257623446516,0.00389349804195459,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.0807900843705577
+"HDAC inhibitor",-1.52,0.02,0.0179960517891872,"transcriptomics, proteomics, metabolomics",3,0,"",0.135870453931087
+"CHK inhibitor",-1.76333333333333,0.100166528008778,0.000835228982998839,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.0346620027944518
diff --git a/Examples/Fig4/DMEA/DMEA_results.csv b/Examples/Fig4/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..1118bfe
--- /dev/null
+++ b/Examples/Fig4/DMEA/DMEA_results.csv
@@ -0,0 +1,250 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"transcriptomics","Pearson.est","EGFR inhibitor",-0.60353,-1.58,0.0575,1249,0.328,"BMS.690514, GW.583340, OSI.420, XL.647, TAK.285, BIBU.1361, ARRY.334543, tyrphostin.AG.1478, BIBX.1382, PD.153035, PD.168393, dacomitinib, osimertinib, poziotinib, AZD8931, icotinib, pelitinib, afatinib, erlotinib, WZ8040, canertinib, gefitinib",1.24033215531037,0.484126156288321,FALSE
+"transcriptomics","Pearson.est","Abl kinase inhibitor",0.22073,0.572,0.941,480,0.962,"GZD824, KW.2449, ponatinib, nilotinib, flumatinib",0.0264103765727431,0.0168249279621871,FALSE
+"transcriptomics","Pearson.est","acetylcholine receptor agonist",0.80534,2.09,0,184,0.0587,"oxiracetam, xanomeline, tremorine, pilocarpine",Inf,1.23136189875239,TRUE
+"transcriptomics","Pearson.est","acetylcholine receptor antagonist",-0.6719,-1.76,0.0291,1029,0.247,"iododexetimide, darifenacin, diphemanil, dicycloverine",1.53610701101409,0.607303046740334,TRUE
+"transcriptomics","Pearson.est","adenosine receptor antagonist",-0.70183,-1.79,0.0123,1430,0.307,"MRS.1220, CGS.15943",1.9100948885606,0.512861624522813,FALSE
+"transcriptomics","Pearson.est","adrenergic receptor agonist",-0.53959,-1.38,0.122,1245,0.502,"methyldopa, xylazine, isoetharine, A61603",0.913640169325252,0.299296282854981,FALSE
+"transcriptomics","Pearson.est","adrenergic receptor antagonist",-0.21824,-0.579,0.929,1134,0.999,"prazosin, atenolol...., metoprolol, pindolol, RS.17053",0.0319842860063582,0.000434511774017692,FALSE
+"transcriptomics","Pearson.est","AKT inhibitor",-0.39785,-1.04,0.397,956,0.768,"MK.2206, palomid.529, GDC.0068, AZD5363, CCT128930, triciribine, A.674563, GSK2110183",0.401209493236885,0.114638779968488,FALSE
+"transcriptomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41958,-1.07,0.368,1152,0.751,"CEP.37440, GW.788388, NVP.TAE684, AP26113, lorlatinib",0.434152181326482,0.124360062995832,FALSE
+"transcriptomics","Pearson.est","androgen receptor antagonist",0.32807,0.852,0.624,105,0.774,"RU.58841",0.204815410317576,0.111259039317107,FALSE
+"transcriptomics","Pearson.est","antioxidant",0.41749,1.07,0.376,212,0.632,"mesna, trolox",0.424812155072339,0.199282921717615,FALSE
+"transcriptomics","Pearson.est","AP inhibitor",0.29867,0.764,0.734,118,0.816,"idronoxil",0.134303940083929,0.0883098412461389,FALSE
+"transcriptomics","Pearson.est","ATPase inhibitor",0.49093,1.25,0.225,432,0.64,"oligomycin.a, digoxin, ouabain, evodiamine, digitoxin, digitoxigenin, NMS.873",0.647817481888638,0.193820026016113,FALSE
+"transcriptomics","Pearson.est","Aurora kinase inhibitor",0.44967,1.18,0.275,356,0.586,"ENMD.2076, PHA.680632, CCT137690, MK.5108, KW.2449, GSK1070916, AMG900, danusertib, PF.03814735, barasertib",0.560667306169737,0.232102383981909,FALSE
+"transcriptomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.6667,1.73,0.0152,177,0.316,"valnemulin, radezolid, azalomycin.b",1.81815641205523,0.500312917381596,FALSE
+"transcriptomics","Pearson.est","bacterial DNA gyrase inhibitor",0.40743,1.02,0.411,365,0.613,"nadifloxacin, novobiocin, norfloxacin, finafloxacin",0.386158178123931,0.212539525481585,FALSE
+"transcriptomics","Pearson.est","BCL inhibitor",0.32788,0.832,0.655,193,0.787,"venetoclax, TW.37",0.183758700008217,0.104025267640935,FALSE
+"transcriptomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.22882,-0.598,0.907,1204,1,"bosutinib, bafetinib",0.0423927129399047,0,FALSE
+"transcriptomics","Pearson.est","benzodiazepine receptor agonist",-0.22866,-0.581,0.929,1051,1,"bentazepam, temazepam, indiplon, lorazepam, gamma.aminobutyric.acid",0.0319842860063582,0,FALSE
+"transcriptomics","Pearson.est","bromodomain inhibitor",0.30663,0.808,0.66,317,0.786,"I.BET.762, PFI.1",0.180456064458131,0.104577453960592,FALSE
+"transcriptomics","Pearson.est","calcium channel blocker",-0.24659,-0.622,0.91,1131,1,"SKF.96365, mibefradil, tetrandrine",0.0409586076789064,0,FALSE
+"transcriptomics","Pearson.est","CC chemokine receptor antagonist",0.54314,1.41,0.139,388,0.889,"ZK811752, UNBS.5162, SB.225002, RS.504393",0.856985199745905,0.0510982390297863,FALSE
+"transcriptomics","Pearson.est","CDK inhibitor",0.36249,0.925,0.514,226,0.711,"PHA.848125, BMS.265246, R547, ribociclib, AZD5438, indisulam, PHA.793887",0.289036881004724,0.148130399270234,FALSE
+"transcriptomics","Pearson.est","CHK inhibitor",-0.69563,-1.8,0.0193,1054,0.575,"LY2603618, AZD7762, SCH.900776, CHIR.124, LY2606368",1.71444269099223,0.24033215531037,FALSE
+"transcriptomics","Pearson.est","cyclooxygenase inhibitor",-0.36026,-0.943,0.499,1272,0.832,"tryptanthrin, phenylbutazone, FR.122047, pterostilbene, FK.3311, naproxen",0.30189945437661,0.0798766737092761,FALSE
+"transcriptomics","Pearson.est","cytochrome P450 inhibitor",-0.44822,-1.14,0.318,1220,0.823,"morin, itraconazole",0.497572880015567,0.0846001647877302,FALSE
+"transcriptomics","Pearson.est","DNA alkylating agent",0.29284,0.742,0.749,268,0.828,"carboplatin, carmustine, temozolomide, cyclophosphamide, mitomycin.c",0.125518182300534,0.0819696632151199,FALSE
+"transcriptomics","Pearson.est","DNA inhibitor",0.52484,1.33,0.162,355,0.641,"valrubicin, carboplatin, carmustine, teroxirone, tirapazamine, bendamustine, mechlorethamine, oxaliplatin, nimorazole, pibenzimol",0.790484985457369,0.193141970481183,FALSE
+"transcriptomics","Pearson.est","DNA methyltransferase inhibitor",0.51627,1.32,0.174,126,0.574,"decitabine, disulfiram",0.7594507517174,0.241088107602027,FALSE
+"transcriptomics","Pearson.est","DNA polymerase inhibitor",0.48256,1.24,0.227,158,0.623,"trifluridine, idoxuridine, foscarnet",0.643974142806877,0.20551195334083,FALSE
+"transcriptomics","Pearson.est","DNA synthesis inhibitor",-0.30022,-0.771,0.717,1418,1,"altretamine, estramustine.phosphate",0.1444808443322,0,FALSE
+"transcriptomics","Pearson.est","dopamine receptor antagonist",0.32081,0.814,0.658,127,0.796,"thioproperazine, paliperidone, raclopride",0.181774106386044,0.0990869322623309,FALSE
+"transcriptomics","Pearson.est","estrogen receptor agonist",0.45859,1.17,0.286,241,0.58,"ethinyl.estradiol, estrone, levonorgestrel",0.543633966870957,0.236572006437063,FALSE
+"transcriptomics","Pearson.est","estrogen receptor antagonist",-0.37156,-0.959,0.494,1321,0.843,"fulvestrant",0.306273051076353,0.0741724253752577,FALSE
+"transcriptomics","Pearson.est","FGFR inhibitor",0.48692,1.21,0.241,107,0.616,"dovitinib, regorafenib, nintedanib",0.617982957425132,0.210419287835575,FALSE
+"transcriptomics","Pearson.est","FLT3 inhibitor",0.43671,1.14,0.288,57,0.607,"sorafenib, dovitinib, TG.101348, ENMD.2076",0.540607512240769,0.216811308924742,FALSE
+"transcriptomics","Pearson.est","glucocorticoid receptor agonist",-0.21996,-0.562,0.958,313,0.98,"triamcinolone, fluticasone.propionate, prednisolone, desonide, prednisolone.hemisuccinate, halobetasol.propionate, ciclesonide, rimexolone, beclomethasone.dipropionate, fludroxycortide, methylprednisolone, dexamethasone.acetate, difluprednate, hydrocortisone, prednisolone.acetate, halcinonide, fluocinolone.acetonide, betamethasone, fluorometholone, piretanide, deflazacort, clobetasol.propionate, flumethasone, flumethasone.pivalate, triamcinolone.acetonide",0.0186344909214556,0.00877392430750515,FALSE
+"transcriptomics","Pearson.est","glutamate receptor antagonist",-0.45688,-1.18,0.242,1100,0.795,"CPP, LY456236, SIB.1757, JNJ.16259685, kynurenic.acid",0.616184634019569,0.0996328713435297,FALSE
+"transcriptomics","Pearson.est","glycogen synthase kinase inhibitor",-0.27288,-0.688,0.829,1019,1,"AZD2858, LY2090314, indirubin, GSK.3.inhibitor.IX",0.0814454694497265,0,FALSE
+"transcriptomics","Pearson.est","growth factor receptor inhibitor",0.39619,1.03,0.419,29,0.617,"PHA.848125",0.377785977033705,0.209714835966758,FALSE
+"transcriptomics","Pearson.est","HCV inhibitor",0.51968,1.36,0.151,155,0.748,"narlaprevir, mericitabine",0.821023052706831,0.126098402135539,FALSE
+"transcriptomics","Pearson.est","HDAC inhibitor",-0.57884,-1.52,0.084,948,0.323,"RG2833, belinostat, pyroxamide, dacinostat, scriptaid, entinostat, R306465, PCI.24781, romidepsin, M.344, panobinostat, SB.939, JNJ.26481585, tacedinaline, nexturastat.a, mocetinostat",1.07572071393812,0.490797477668897,FALSE
+"transcriptomics","Pearson.est","histamine receptor antagonist",-0.42199,-1.09,0.345,1359,0.756,"lafutidine, famotidine, chloropyramine",0.462180904926726,0.121478204498793,FALSE
+"transcriptomics","Pearson.est","HMGCR inhibitor",0.54206,1.39,0.111,417,0.751,"fluvastatin, atorvastatin, pitavastatin, mevastatin, lovastatin",0.954677021213343,0.124360062995832,FALSE
+"transcriptomics","Pearson.est","HSP inhibitor",0.30096,0.786,0.719,358,0.802,"SNX.2112, PU.H71, NVP.AUY922, BIIB021, ganetespib, XL888",0.143271109617117,0.0958256317158365,FALSE
+"transcriptomics","Pearson.est","JAK inhibitor",0.47121,1.21,0.244,124,0.616,"AZD1480, TG.101348, baricitinib, AZ960, WHI.P154",0.612610173661271,0.210419287835575,FALSE
+"transcriptomics","Pearson.est","KIT inhibitor",0.46077,1.19,0.261,83,0.622,"sorafenib, OSI.930, regorafenib, masitinib",0.583359492661719,0.206209615309181,FALSE
+"transcriptomics","Pearson.est","MDM inhibitor",0.3999,1.04,0.396,100,0.641,"idasanutlin, nutlin.3",0.402304814074488,0.193141970481183,FALSE
+"transcriptomics","Pearson.est","MEK inhibitor",-0.20098,-0.502,0.978,1443,0.98,"BIX.02188",0.00966114521239857,0.00877392430750515,FALSE
+"transcriptomics","Pearson.est","MET inhibitor",-0.32987,-0.868,0.585,1382,0.898,"INC.280",0.23284413391782,0.0467236633326956,FALSE
+"transcriptomics","Pearson.est","microtubule inhibitor",-0.27591,-0.711,0.813,1434,1,"estramustine.phosphate",0.0899094544059319,0,FALSE
+"transcriptomics","Pearson.est","mTOR inhibitor",0.41613,1.11,0.326,295,0.611,"ku.0063794, AZD2014, voxtalisib, MLN0128, torin.1, XL388, NVP.BEZ235, AZD8055, WYE.354, everolimus",0.486782399932061,0.213958789757446,FALSE
+"transcriptomics","Pearson.est","NFkB pathway inhibitor",0.22458,0.568,0.941,151,0.945,"EVP4593, betulinic.acid",0.0264103765727431,0.0245681914907371,FALSE
+"transcriptomics","Pearson.est","opioid receptor agonist",0.71254,1.83,0.0124,130,0.221,"trimebutine, salvinorin.a",1.90657831483776,0.655607726314889,TRUE
+"transcriptomics","Pearson.est","p38 MAPK inhibitor",-0.41839,-1.1,0.348,1183,0.79,"CMPD.1, SB.239063, TAK.715",0.458420756053419,0.102372908709559,FALSE
+"transcriptomics","Pearson.est","PARP inhibitor",0.5393,1.39,0.126,245,0.751,"olaparib, niraparib, talazoparib",0.899629454882437,0.124360062995832,FALSE
+"transcriptomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.51602,1.33,0.166,337,0.641,"sorafenib, dovitinib, linifanib, regorafenib, masitinib, nintedanib, crenolanib, axitinib, CP.673451, pazopanib, tandutinib, lenvatinib",0.779891911959945,0.193141970481183,FALSE
+"transcriptomics","Pearson.est","phosphatase inhibitor",-0.51711,-1.34,0.168,1395,0.517,"mycophenolate.mofetil, BVT.948",0.774690718274137,0.286509456906058,FALSE
+"transcriptomics","Pearson.est","phosphodiesterase inhibitor",-0.65792,-1.68,0.0316,1298,0.3,"cilostamide, zardaverine, enoximone, GSK256066",1.5003129173816,0.522878745280338,FALSE
+"transcriptomics","Pearson.est","PI3K inhibitor",0.28333,0.719,0.785,503,0.842,"GDC.0941, voxtalisib, ZSTK.474, NVP.BEZ235, taselisib, PI3K.IN.2, PF.04691502, LY303511, CH5132799, TG.100713, GSK2126458, PIK.75, GDC.0980, alpelisib",0.105130343254747,0.0746879085003505,FALSE
+"transcriptomics","Pearson.est","PLK inhibitor",0.74254,1.92,0.00403,378,0.16,"NMS.1286937, volasertib, GW.843682X, BI.2536, rigosertib, GSK461364, HMN.214",2.39469495385889,0.795880017344075,TRUE
+"transcriptomics","Pearson.est","potassium channel blocker",0.39764,1,0.429,16,0.625,"ML133",0.367542707815276,0.204119982655925,FALSE
+"transcriptomics","Pearson.est","PPAR receptor agonist",-0.59385,-1.53,0.0807,1077,0.353,"clofibrate, oleoylethanolamide, S26948, pterostilbene, GW.501516",1.09312646527793,0.452225294612177,FALSE
+"transcriptomics","Pearson.est","progesterone receptor agonist",0.23746,0.607,0.927,415,0.952,"nomegestrol.acetate, levonorgestrel, tanaproget, danazol",0.0329202658555029,0.0213630516155257,FALSE
+"transcriptomics","Pearson.est","proteasome inhibitor",-0.34308,-0.879,0.596,940,0.918,"carfilzomib, ONX.0914, oprozomib, ixazomib.citrate",0.224753740259764,0.0371573187987575,FALSE
+"transcriptomics","Pearson.est","protein synthesis inhibitor",0.43749,1.12,0.313,244,0.618,"anguidine, harringtonine, cycloheximide, mercaptopurine, bruceantin, thiostrepton",0.504455662453552,0.209011524911184,FALSE
+"transcriptomics","Pearson.est","protein tyrosine kinase inhibitor",0.34577,0.888,0.583,19,0.734,"mubritinib",0.234331445240986,0.134303940083929,FALSE
+"transcriptomics","Pearson.est","RAF inhibitor",0.40235,1.06,0.365,220,0.627,"sorafenib, regorafenib, dabrafenib, SB.590885",0.437707135543525,0.202732459169284,FALSE
+"transcriptomics","Pearson.est","RET tyrosine kinase inhibitor",0.59221,1.51,0.0781,77,0.69,"sorafenib, regorafenib",1.1073489661227,0.161150909262745,FALSE
+"transcriptomics","Pearson.est","retinoid receptor agonist",-0.26942,-0.714,0.824,1401,1,"CD.437",0.0840727883028842,0,FALSE
+"transcriptomics","Pearson.est","ribonucleotide reductase inhibitor",0.51093,1.32,0.171,538,0.574,"cladribine, fludarabine.phosphate, cytarabine, triapine, pentostatin",0.767003889607846,0.241088107602027,FALSE
+"transcriptomics","Pearson.est","serotonin receptor agonist",0.60408,1.55,0.0675,504,0.686,"zolmitriptan, SR.57227A, aripiprazole, pardoprunox, NAN.190",1.17069622716898,0.163675884293248,FALSE
+"transcriptomics","Pearson.est","serotonin receptor antagonist",0.40856,1.07,0.39,74,0.632,"SB.200646, SB.216641, paliperidone",0.408935392973501,0.199282921717615,FALSE
+"transcriptomics","Pearson.est","sodium channel blocker",-0.44082,-1.11,0.341,1302,0.828,"lappaconite, benzethonium, cibenzoline",0.467245621007502,0.0819696632151199,FALSE
+"transcriptomics","Pearson.est","src inhibitor",-0.37709,-0.974,0.461,1204,0.858,"bosutinib, saracatinib, PP.2, PP.1",0.336299074610352,0.0665127121512946,FALSE
+"transcriptomics","Pearson.est","sterol demethylase inhibitor",0.3835,0.98,0.471,397,0.639,"lanoconazole, sulconazole, chlormidazole, ketoconazole",0.326979092871104,0.1944991418416,FALSE
+"transcriptomics","Pearson.est","TGF beta receptor inhibitor",-0.22757,-0.585,0.925,909,1,"SB.525334, D.4476, repsox, LY2109761",0.0338582672609674,0,FALSE
+"transcriptomics","Pearson.est","thymidylate synthase inhibitor",0.51877,1.34,0.167,131,0.732,"trifluridine, carmofur",0.777283528852417,0.135488918941608,FALSE
+"transcriptomics","Pearson.est","topoisomerase inhibitor",0.50833,1.3,0.179,232,0.578,"idarubicin, valrubicin, mitoxantrone, etoposide.phosphate, TAS.103, amonafide, amsacrine, voreloxin, topotecan, dexrazoxane, nemorubicin",0.747146969020107,0.238072161579471,FALSE
+"transcriptomics","Pearson.est","tubulin polymerization inhibitor",0.40708,1.03,0.404,359,0.617,"verubulin, docetaxel, KX2.391, epothilone.b, mebendazole, vinblastine, taltobulin, vindesine, fosbretabulin, flubendazole",0.393618634889395,0.209714835966758,FALSE
+"transcriptomics","Pearson.est","tyrosine kinase inhibitor",0.34788,0.897,0.555,129,0.737,"mubritinib, sorafenib, regorafenib, hypericin",0.255707016877324,0.132532512140949,FALSE
+"transcriptomics","Pearson.est","VEGFR inhibitor",0.45481,1.18,0.274,171,0.586,"sorafenib, tivozanib, dovitinib, linifanib, OSI.930, ENMD.2076, regorafenib, nintedanib, golvatinib, axitinib, foretinib",0.562249437179612,0.232102383981909,FALSE
+"transcriptomics","Pearson.est","vitamin D receptor agonist",-0.65049,-1.66,0.0426,1277,0.272,"maxacalcitol, calcitriol, paricalcitol",1.37059040089728,0.565431095965801,FALSE
+"proteomics","Pearson.est","EGFR inhibitor",-0.67568,-1.76,0.018,1140,0.384,"tucatinib, GW.583340, lapatinib, neratinib, XL.647, tyrphostin.AG.1478, CP.724714, BIBX.1382, poziotinib, TAK.285, AEE788, rociletinib, PD.153035, ARRY.334543, AZD8931, BMS.690514, OSI.420, vandetanib, BIBU.1361, dacomitinib, icotinib, gefitinib, erlotinib, canertinib, PD.168393, osimertinib, afatinib, WZ8040, pelitinib",1.74472749489669,0.415668775632469,FALSE
+"proteomics","Pearson.est","Abl kinase inhibitor",0.21727,0.579,0.938,1136,0.938,"GZD824, ponatinib, dasatinib, KW.2449, bafetinib, tozasertib, flumatinib, nilotinib, ZM.306416, bosutinib, imatinib, metatinib",0.0277971616209356,0.0277971616209356,FALSE
+"proteomics","Pearson.est","acetylcholine receptor agonist",0.53728,1.49,0.0769,286,0.618,"xanomeline, nicotine, pilocarpine",1.11407366019857,0.209011524911184,FALSE
+"proteomics","Pearson.est","acetylcholine receptor antagonist",-0.35846,-0.892,0.577,1371,1,"dicycloverine",0.238824186844269,0,FALSE
+"proteomics","Pearson.est","adenosine receptor antagonist",-0.64883,-1.64,0.0386,1336,0.447,"MRS.1220, CGS.15943",1.41341269532825,0.349692476868064,FALSE
+"proteomics","Pearson.est","adrenergic receptor agonist",-0.32897,-0.845,0.64,749,1,"norepinephrine, xylazine, midodrine, metaraminol, epinephrine, clenbuterol, methyldopa, terbutaline, isoetharine, isoxsuprine, oxymetazoline, A61603",0.193820026016113,0,FALSE
+"proteomics","Pearson.est","adrenergic receptor antagonist",0.23079,0.607,0.893,186,0.976,"dihydroergocristine, naftidrofuryl, atipamezole, metoprolol, idazoxan",0.0491485411114536,0.0105501823333082,FALSE
+"proteomics","Pearson.est","AKT inhibitor",-0.61633,-1.59,0.0405,1044,0.346,"ONC201, GSK2110183, uprosertib, triciribine, AZD5363, CCT128930, palomid.529",1.39254497678533,0.460923901207223,FALSE
+"proteomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.29684,-0.741,0.763,824,0.878,"SB.505124, AZD3463, CEP.37440, GW.788388, NVP.TAE684, AP26113",0.11747546204512,0.0565054840938974,FALSE
+"proteomics","Pearson.est","androgen receptor antagonist",0.29057,0.787,0.686,1029,1,"RU.58841, enzalutamide, nilutamide, bicalutamide, flutamide, cyproterone.acetate",0.163675884293248,0,FALSE
+"proteomics","Pearson.est","antioxidant",0.41032,1.1,0.325,223,0.888,"trolox, mesna",0.488116639021126,0.051587034221399,FALSE
+"proteomics","Pearson.est","AP inhibitor",-0.39563,-1.01,0.466,864,0.878,"birinapant, LCL.161, tanshinone.i, embelin",0.33161408331,0.0565054840938974,FALSE
+"proteomics","Pearson.est","ATPase inhibitor",0.75913,2.03,0.0126,164,0.0599,"k.strophanthidin, oligomycin.a, digoxin, NMS.873, rabeprazole, digitoxigenin, evodiamine",1.89962945488244,1.22257317761069,TRUE
+"proteomics","Pearson.est","Aurora kinase inhibitor",0.43678,1.18,0.266,379,0.775,"ENMD.2076, MK.5108, PHA.680632, danusertib, AT.9283, barasertib, AMG900, CCT137690, GSK1070916, barasertib.HQPA, CYC116",0.575118363368933,0.11069829749369,FALSE
+"proteomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.48546,1.28,0.195,167,0.696,"radezolid, josamycin",0.709965388637482,0.157390760389438,FALSE
+"proteomics","Pearson.est","bacterial DNA gyrase inhibitor",-0.25033,-0.633,0.869,1209,0.949,"trovafloxacin, sparfloxacin",0.0609802235513335,0.0227337875727074,FALSE
+"proteomics","Pearson.est","BCL inhibitor",0.29931,0.796,0.709,1017,1,"venetoclax, gossypol, TW.37, ABT.737, obatoclax, navitoclax, HA14.1, oridonin",0.149353764816933,0,FALSE
+"proteomics","Pearson.est","Bcr.Abl kinase inhibitor",0.21697,0.58,0.934,1136,0.967,"GZD824, ponatinib, dasatinib, bafetinib, tozasertib, flumatinib, nilotinib, bosutinib, imatinib, metatinib",0.0296531237699066,0.0145735259169983,FALSE
+"proteomics","Pearson.est","benzodiazepine receptor agonist",-0.43936,-1.11,0.335,1117,0.76,"lorazepam, indiplon, zaleplon, temazepam, CGS.20625",0.474955192963155,0.119186407719209,FALSE
+"proteomics","Pearson.est","bromodomain inhibitor",-0.50519,-1.28,0.203,967,0.568,"I.BET.762, JQ1...., I.BET151, bromosporine",0.692503962086787,0.245651664288981,FALSE
+"proteomics","Pearson.est","calcium channel blocker",0.23877,0.649,0.886,26,0.997,"carboxyamidotriazole",0.0525662781129492,0.00130484168834428,FALSE
+"proteomics","Pearson.est","CC chemokine receptor antagonist",0.50359,1.38,0.13,129,0.643,"UNBS.5162, SB.225002, ZK811752",0.886056647693163,0.191789027075778,FALSE
+"proteomics","Pearson.est","CDK inhibitor",-0.18259,-0.452,0.995,981,1,"alvocidib, dinaciclib, TG.02, kenpaullone, BMS.387032, indirubin, CR8..R., arcyriaflavin.a",0.00217691925427455,0,FALSE
+"proteomics","Pearson.est","CHK inhibitor",-0.64686,-1.65,0.0363,1052,0.563,"AZD7762, CHIR.124, SCH.900776, LY2603618, LY2606368",1.44009337496389,0.249491605148654,FALSE
+"proteomics","Pearson.est","cyclooxygenase inhibitor",-0.34465,-0.87,0.62,1220,1,"ketoprofen, FR.122047, FK.3311, tryptanthrin, naproxen, indoprofen",0.207608310501746,0,FALSE
+"proteomics","Pearson.est","cytochrome P450 inhibitor",-0.46402,-1.18,0.272,1179,0.68,"cobicistat, itraconazole",0.565431095965801,0.167491087293764,FALSE
+"proteomics","Pearson.est","DNA alkylating agent",-0.3084,-0.766,0.73,1013,0.974,"satraplatin, TH.302, melphalan, cisplatin, estramustine, ifosfamide, dacarbazine",0.136677139879544,0.0114410431213845,FALSE
+"proteomics","Pearson.est","DNA inhibitor",0.43601,1.2,0.268,344,0.802,"carboplatin, metronidazole, mechlorethamine, teroxirone, oxaliplatin, sangivamycin, tirapazamine, carmustine, chlorambucil, pibenzimol",0.571865205971211,0.0958256317158365,FALSE
+"proteomics","Pearson.est","DNA methyltransferase inhibitor",-0.56815,-1.42,0.099,1219,0.466,"RG108, fdcyd, azacitidine",1.00436480540245,0.33161408331,FALSE
+"proteomics","Pearson.est","DNA polymerase inhibitor",-0.26746,-0.677,0.863,931,0.921,"menadione, adefovir.dipivoxil, cidofovir, cephalomannine",0.0639892042847904,0.0357403698031511,FALSE
+"proteomics","Pearson.est","DNA synthesis inhibitor",-0.17625,-0.444,0.995,1110,0.992,"estramustine.phosphate, cisplatin, altretamine",0.00217691925427455,0.00348832784582135,FALSE
+"proteomics","Pearson.est","dopamine receptor antagonist",0.26079,0.717,0.815,1,1,"thioproperazine",0.0888423912600234,0,FALSE
+"proteomics","Pearson.est","estrogen receptor agonist",0.33985,0.916,0.543,292,1,"estrone, erteberel, levonorgestrel, estradiol.cypionate",0.265200170411153,0,FALSE
+"proteomics","Pearson.est","estrogen receptor antagonist",0.3939,1.07,0.334,880,0.891,"fulvestrant, toremifene, tamoxifen, clomifene, danazol, raloxifene",0.476253533188435,0.0501222959631252,FALSE
+"proteomics","Pearson.est","FGFR inhibitor",0.30912,0.802,0.641,339,1,"dovitinib, nintedanib, AZD4547, lenvatinib, erdafitinib, regorafenib",0.193141970481183,0,FALSE
+"proteomics","Pearson.est","FLT3 inhibitor",0.25441,0.688,0.829,108,1,"dovitinib, tyrphostin.AG.1296, ENMD.2076",0.0814454694497265,0,FALSE
+"proteomics","Pearson.est","glucocorticoid receptor agonist",0.31865,0.876,0.589,257,1,"beclomethasone.dipropionate, hydrocortisone, fluticasone.propionate, desonide, triamcinolone, dexamethasone.acetate",0.229884705212898,0,FALSE
+"proteomics","Pearson.est","glutamate receptor antagonist",-0.52247,-1.33,0.171,1040,0.501,"CPP, diazooxonorleucine, SIB.1757, ACDPP, MTPG, latrepirdine, LY456236",0.767003889607846,0.300162274132754,FALSE
+"proteomics","Pearson.est","glycogen synthase kinase inhibitor",-0.59749,-1.47,0.0721,1080,0.449,"kenpaullone, indirubin, LY2090314, AZD2858, GSK.3.inhibitor.IX",1.14206473528057,0.347753658996677,FALSE
+"proteomics","Pearson.est","growth factor receptor inhibitor",0.55679,1.53,0.0956,225,0.676,"PHA.848125, danusertib",1.0195421077239,0.170053304058364,FALSE
+"proteomics","Pearson.est","HCV inhibitor",-0.64199,-1.63,0.039,1272,0.381,"PSI.7976, embelin, Ro.9187",1.4089353929735,0.419075024324381,FALSE
+"proteomics","Pearson.est","HDAC inhibitor",-0.60905,-1.54,0.0638,966,0.354,"ACY.1215, resminostat, scriptaid, dacinostat, belinostat, mocetinostat, givinostat, pyroxamide, RG2833, tacedinaline, vorinostat, M.344, entinostat, PCI.24781, romidepsin, R306465, panobinostat, nexturastat.a, JNJ.26481585, SB.939",1.19517932127884,0.450996737974212,FALSE
+"proteomics","Pearson.est","histamine receptor antagonist",-0.55943,-1.39,0.127,923,0.453,"BF2.649, cimetidine, cyproheptadine, famotidine, astemizole, zolantidine, tiotidine, terfenadine, levocetirizine, ICI.162846, tecastemizole, chloropyramine",0.896196279044043,0.343901797987168,FALSE
+"proteomics","Pearson.est","HMGCR inhibitor",-0.46003,-1.15,0.288,1081,0.707,"mevastatin, simvastatin",0.540607512240769,0.150580586203101,FALSE
+"proteomics","Pearson.est","HSP inhibitor",-0.48905,-1.22,0.253,999,0.628,"NVP.AUY922, tanespimycin, XL888, SNX.5422, guanidine, alvespimycin, VER.49009, KW.2478",0.596879478824182,0.202040356262804,FALSE
+"proteomics","Pearson.est","JAK inhibitor",-0.36557,-0.93,0.505,1384,0.987,"LY2784544, pacritinib, atiprimod",0.296708621881339,0.00568284733036327,FALSE
+"proteomics","Pearson.est","KIT inhibitor",-0.28892,-0.741,0.775,905,0.878,"tandutinib, KI.8751, sunitinib, cediranib, motesanib, imatinib, midostaurin, vatalanib, telatinib",0.11069829749369,0.0565054840938974,FALSE
+"proteomics","Pearson.est","MDM inhibitor",0.54338,1.45,0.117,117,0.591,"idasanutlin, nutlin.3, AMG.232",0.931814138253838,0.228412519118745,FALSE
+"proteomics","Pearson.est","MEK inhibitor",-0.29678,-0.748,0.757,1426,0.954,"nobiletin, BIX.02188",0.120904120499927,0.0204516252959049,FALSE
+"proteomics","Pearson.est","MET inhibitor",-0.62663,-1.56,0.0598,1243,0.357,"AMG458, INC.280",1.22329881601159,0.447331783887807,FALSE
+"proteomics","Pearson.est","microtubule inhibitor",0.23435,0.645,0.876,1111,0.968,"vinblastine, vinflunine, D.64131, secnidazole, colchicine, cytochalasin.b, cabazitaxel, triclabendazole, podophyllotoxin, estramustine.phosphate",0.0574958938319193,0.0141246426916063,FALSE
+"proteomics","Pearson.est","mTOR inhibitor",0.37342,1.01,0.419,338,0.978,"AZD2014, ku.0063794, MLN0128, torin.1, voxtalisib, WYE.125132, XL388, SB.2343, PP242, PF.04691502, OSI.027, GDC.0980, NVP.BEZ235",0.377785977033705,0.00966114521239857,FALSE
+"proteomics","Pearson.est","NFkB pathway inhibitor",-0.30507,-0.761,0.74,1253,0.957,"IKK.2.inhibitor.V, bortezomib, Ro.106.9920",0.130768280269024,0.0190880622231565,FALSE
+"proteomics","Pearson.est","opioid receptor agonist",-0.31367,-0.79,0.717,1330,1,"salvinorin.a",0.1444808443322,0,FALSE
+"proteomics","Pearson.est","p38 MAPK inhibitor",-0.40226,-1.01,0.466,1002,0.878,"SB.239063, CMPD.1, VX.702, TAK.715",0.33161408331,0.0565054840938974,FALSE
+"proteomics","Pearson.est","PARP inhibitor",-0.42722,-1.09,0.346,1073,0.771,"PJ.34, endo.IWR.1, E7449",0.460923901207223,0.112945621949043,FALSE
+"proteomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.23385,-0.591,0.942,1282,0.966,"vatalanib, trapidil, telatinib, orantinib",0.0259490972071227,0.0150228735845067,FALSE
+"proteomics","Pearson.est","phosphatase inhibitor",0.24423,0.651,0.881,127,1,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.0550240915879521,0,FALSE
+"proteomics","Pearson.est","phosphodiesterase inhibitor",-0.55705,-1.41,0.117,961,0.448,"EMD.53998, anagrelide, enoximone, papaverine, cilostamide, GSK256066, zardaverine, YM.976",0.931814138253838,0.348721986001856,FALSE
+"proteomics","Pearson.est","PI3K inhibitor",0.32388,0.859,0.606,338,1,"GDC.0941, idelalisib, ZSTK.474, voxtalisib, SB.2343, buparlisib, PI3K.IN.2, PF.04691502, GDC.0980, NVP.BEZ235",0.217527375833714,0,FALSE
+"proteomics","Pearson.est","PLK inhibitor",0.74532,2.04,0.00265,374,0.0831,"NMS.1286937, volasertib, GW.843682X, HMN.214, rigosertib, BI.2536, GSK461364",2.57675412606319,1.08039897621589,TRUE
+"proteomics","Pearson.est","potassium channel blocker",-0.32325,-0.803,0.691,974,1,"meglitinide, oleoylethanolamide, dofetilide",0.160521952625802,0,FALSE
+"proteomics","Pearson.est","PPAR receptor agonist",-0.30568,-0.768,0.738,1055,0.997,"GW.501516, oleoylethanolamide, S26948",0.131943638176958,0.00130484168834428,FALSE
+"proteomics","Pearson.est","progesterone receptor agonist",0.49639,1.36,0.141,281,0.601,"nomegestrol.acetate, tanaproget, levonorgestrel, norethindrone",0.85078088734462,0.22112552799726,FALSE
+"proteomics","Pearson.est","proteasome inhibitor",-0.69711,-1.76,0.0185,1053,0.384,"oprozomib, ixazomib, ONX.0914, bortezomib, carfilzomib, ixazomib.citrate",1.73282827159699,0.415668775632469,FALSE
+"proteomics","Pearson.est","protein synthesis inhibitor",0.29808,0.798,0.682,365,1,"harringtonine, clofoctol, anguidine, mercaptopurine, clindamycin.phosphate, bruceantin, chloramphenicol.palmitate, cycloheximide",0.166215625343521,0,FALSE
+"proteomics","Pearson.est","protein tyrosine kinase inhibitor",-0.3089,-0.773,0.75,948,1,"BMS.599626, tyrphostin.A9, NVP.TAE226, CP.724714, AV.412, rheochrysidin",0.1249387366083,0,FALSE
+"proteomics","Pearson.est","RAF inhibitor",-0.53101,-1.37,0.16,1181,0.459,"CEP.32496, vemurafenib, GDC.0879, dabrafenib",0.795880017344075,0.338187314462739,FALSE
+"proteomics","Pearson.est","RET tyrosine kinase inhibitor",-0.57673,-1.43,0.107,1358,0.488,"apatinib, vandetanib",0.97061622231479,0.311580177997289,FALSE
+"proteomics","Pearson.est","retinoid receptor agonist",0.27461,0.736,0.757,247,1,"adapalene, fenretinide, LE.135",0.120904120499927,0,FALSE
+"proteomics","Pearson.est","ribonucleotide reductase inhibitor",0.33582,0.91,0.543,183,1,"cytarabine, hydroxyurea, pentostatin",0.265200170411153,0,FALSE
+"proteomics","Pearson.est","serotonin receptor agonist",-0.30814,-0.769,0.739,1186,1,"aripiprazole, ipsapirone",0.131355561605174,0,FALSE
+"proteomics","Pearson.est","serotonin receptor antagonist",-0.34005,-0.867,0.61,1185,1,"RS.16566, aripiprazole, tropisetron, lerisetron, SB.228357",0.214670164989233,0,FALSE
+"proteomics","Pearson.est","sodium channel blocker",-0.32741,-0.836,0.649,1226,1,"triamterene, lappaconite, mexiletine",0.187755303199631,0,FALSE
+"proteomics","Pearson.est","src inhibitor",-0.29137,-0.745,0.779,835,0.914,"TG.100572, PP.1, ZM.306416, bosutinib, saracatinib, PP.2",0.108462542327436,0.0390538042661686,FALSE
+"proteomics","Pearson.est","sterol demethylase inhibitor",0.76232,2.05,0.00248,149,0.158,"chlormidazole, sulconazole, posaconazole, lanoconazole",2.60554831917378,0.801342913045577,TRUE
+"proteomics","Pearson.est","TGF beta receptor inhibitor",-0.64087,-1.61,0.0594,1222,0.361,"SB.431542, D.4476, repsox, LY2109761",1.22621355501881,0.442492798094342,FALSE
+"proteomics","Pearson.est","thymidylate synthase inhibitor",-0.39674,-0.98,0.474,1437,0.908,"doxifluridine",0.324221658325915,0.0419141514789149,FALSE
+"proteomics","Pearson.est","topoisomerase inhibitor",0.25839,0.705,0.818,229,1,"mitoxantrone, idarubicin, dexrazoxane, etoposide.phosphate, epirubicin, TAS.103, doxorubicin",0.087246696328677,0,FALSE
+"proteomics","Pearson.est","tubulin polymerization inhibitor",0.23959,0.652,0.896,271,1,"verubulin, fenbendazole, BNC105, vinblastine, vindesine, mebendazole",0.0476919903378748,0,FALSE
+"proteomics","Pearson.est","tyrosine kinase inhibitor",-0.28636,-0.718,0.808,910,0.891,"tyrphostin.AG.99, sunitinib, BMS.599626, tyrphostin.A9, NVP.TAE226, AMG.208, CP.724714, AV.412, rheochrysidin, apatinib, vandetanib",0.0925886392254138,0.0501222959631252,FALSE
+"proteomics","Pearson.est","VEGFR inhibitor",-0.29288,-0.747,0.771,1259,0.933,"MGCD.265, vatalanib, AEE788, lucitanib, BMS.690514, vandetanib, telatinib, orantinib",0.112945621949043,0.0301183562535,FALSE
+"proteomics","Pearson.est","vitamin D receptor agonist",-0.49135,-1.26,0.224,993,0.578,"ercalcitriol, paricalcitol, tacalcitol, maxacalcitol, calcitriol",0.649751981665837,0.238072161579471,FALSE
+"metabolomics","Pearson.est","EGFR inhibitor",-0.40853,-1.06,0.383,1048,0.713,"gefitinib, erlotinib, tucatinib, AEE788, WZ8040, dacomitinib, BMS.599626, BMS.690514, BIBU.1361, vandetanib, canertinib, neratinib, PD.168393, OSI.420, afatinib, pelitinib, brigatinib, TAK.285, osimertinib, PD.153035",0.416801226031377,0.146910470148134,FALSE
+"metabolomics","Pearson.est","Abl kinase inhibitor",-0.62703,-1.63,0.0538,1070,0.283,"bafetinib, flumatinib, tozasertib, dasatinib, nilotinib, GZD824, metatinib, ponatinib",1.26921772433361,0.54821356447571,FALSE
+"metabolomics","Pearson.est","acetylcholine receptor agonist",0.61238,1.55,0.0845,186,0.389,"pilocarpine, oxiracetam, nefiracetam",1.07314329105031,0.410050398674292,FALSE
+"metabolomics","Pearson.est","acetylcholine receptor antagonist",-0.22665,-0.587,0.929,1093,0.975,"darifenacin, dicycloverine",0.0319842860063582,0.0109953843014632,FALSE
+"metabolomics","Pearson.est","adenosine receptor antagonist",0.3039,0.795,0.693,82,0.941,"SCH.58261",0.159266765388193,0.0264103765727431,FALSE
+"metabolomics","Pearson.est","adrenergic receptor agonist",-0.37758,-0.983,0.47,1150,0.695,"epinephrine, clenbuterol, A61603, isoetharine, metaraminol, terbutaline",0.327902142064283,0.158015195409886,FALSE
+"metabolomics","Pearson.est","adrenergic receptor antagonist",0.37698,0.962,0.471,316,0.894,"prazosin, propranolol, atenolol......, naftidrofuryl, oxprenolol, imiloxan",0.326979092871104,0.0486624812040823,FALSE
+"metabolomics","Pearson.est","AKT inhibitor",0.23808,0.626,0.905,219,1,"AT7867, ONC201",0.0433514207947967,0,FALSE
+"metabolomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.50162,-1.3,0.169,1033,0.506,"alectinib, GW.788388, AZD3463, AP26113, brigatinib, CEP.37440",0.772113295386326,0.295849483160201,FALSE
+"metabolomics","Pearson.est","androgen receptor antagonist",0.77336,2.02,0.00789,264,0.0464,"bicalutamide, enzalutamide, nilutamide, RU.58841",2.10292299679058,1.33348201944512,TRUE
+"metabolomics","Pearson.est","antioxidant",0.31137,0.791,0.715,999,0.859,"trolox, mesna, chlorogenic.acid, benfotiamine, taurine, rutin",0.145693958198919,0.0660068361687577,FALSE
+"metabolomics","Pearson.est","AP inhibitor",-0.3765,-0.974,0.457,1135,0.686,"embelin, LCL.161",0.34008379993015,0.163675884293248,FALSE
+"metabolomics","Pearson.est","ATPase inhibitor",0.59873,1.56,0.0913,267,0.434,"k.strophanthidin, rabeprazole, evodiamine, digitoxigenin, oligomycin.a, digitoxin",1.0395292224657,0.362510270487489,FALSE
+"metabolomics","Pearson.est","Aurora kinase inhibitor",0.20118,0.528,0.975,70,0.994,"PHA.680632, CCT129202",0.0109953843014632,0.00261361560268669,FALSE
+"metabolomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.35427,-0.906,0.556,1294,0.692,"dirithromycin, tedizolid",0.254925208417942,0.159893905543242,FALSE
+"metabolomics","Pearson.est","bacterial DNA gyrase inhibitor",0.41822,1.08,0.339,177,0.762,"norfloxacin, finafloxacin, nadifloxacin",0.469800301796918,0.1180450286604,FALSE
+"metabolomics","Pearson.est","BCL inhibitor",-0.43591,-1.11,0.314,1183,0.683,"gossypol, HA14.1, navitoclax",0.503070351926785,0.165579296318467,FALSE
+"metabolomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.68737,-1.78,0.0225,1070,0.204,"bafetinib, flumatinib, tozasertib, dasatinib, nilotinib, GZD824, metatinib, ponatinib",1.64781748188864,0.690369832574101,TRUE
+"metabolomics","Pearson.est","benzodiazepine receptor agonist",0.50126,1.31,0.181,256,0.57,"eprinomectin, bentazepam, nefiracetam, piperazine",0.742321425130815,0.244125144327509,FALSE
+"metabolomics","Pearson.est","bromodomain inhibitor",0.36685,0.942,0.526,919,0.857,"I.BET.762, I.BET151, JQ1...., OTX015, bromosporine, PFI.1",0.279014255846261,0.0670191780768018,FALSE
+"metabolomics","Pearson.est","calcium channel blocker",-0.18645,-0.481,0.986,895,1,"efonidipine.monoethanolate, mibefradil, SR.33805, tetrandrine, SKF.96365, penfluridol",0.0061230850587888,0,FALSE
+"metabolomics","Pearson.est","CC chemokine receptor antagonist",0.29746,0.77,0.743,169,0.864,"SB.225002, PF.04136309",0.129011186239425,0.0634862575211067,FALSE
+"metabolomics","Pearson.est","CDK inhibitor",-0.47432,-1.22,0.22,1065,0.578,"kenpaullone, palbociclib, alvocidib, arcyriaflavin.a, dinaciclib, ribociclib, AT.7519, abemaciclib, P276.00",0.657577319177794,0.238072161579471,FALSE
+"metabolomics","Pearson.est","CHK inhibitor",-0.71577,-1.84,0.0153,1297,0.181,"LY2603618, AZD7762, SCH.900776, LY2606368",1.8153085691824,0.742321425130815,TRUE
+"metabolomics","Pearson.est","cyclooxygenase inhibitor",0.24554,0.635,0.892,523,1,"aspirin, sulfasalazine, pterostilbene, phenazone, amfenac, AM.404, naproxen, ramifenazone, phenylbutazone, tepoxalin, piroxicam, meloxicam",0.0496351456238769,0,FALSE
+"metabolomics","Pearson.est","cytochrome P450 inhibitor",-0.41748,-1.07,0.387,1402,0.725,"itraconazole",0.412289034981089,0.139661993429006,FALSE
+"metabolomics","Pearson.est","DNA alkylating agent",-0.37591,-0.985,0.439,1261,0.716,"melphalan, ifosfamide, cisplatin, estramustine",0.357535479757879,0.145086977692144,FALSE
+"metabolomics","Pearson.est","DNA inhibitor",0.51516,1.33,0.157,182,0.579,"carboplatin, mechlorethamine, tirapazamine, bendamustine, metronidazole, nimorazole",0.804100347590766,0.237321436272564,FALSE
+"metabolomics","Pearson.est","DNA methyltransferase inhibitor",-0.6451,-1.63,0.0382,1216,0.283,"fdcyd, decitabine, azacitidine",1.41793663708829,0.54821356447571,FALSE
+"metabolomics","Pearson.est","DNA polymerase inhibitor",0.41261,1.07,0.382,283,0.743,"famciclovir, foscarnet, cephalomannine",0.417936637088291,0.129011186239425,FALSE
+"metabolomics","Pearson.est","DNA synthesis inhibitor",0.30546,0.791,0.704,322,0.859,"artesunate, azodicarbonamide, CB.10.277, artemisinin, nelarabine, altretamine",0.152427340857888,0.0660068361687577,FALSE
+"metabolomics","Pearson.est","dopamine receptor antagonist",0.52613,1.34,0.157,125,0.617,"thioproperazine, clebopride, remoxipride, raclopride",0.804100347590766,0.209714835966758,FALSE
+"metabolomics","Pearson.est","estrogen receptor agonist",0.55447,1.41,0.125,170,0.539,"ethinyl.estradiol, estrone, erteberel, levonorgestrel",0.903089986991944,0.268411234813261,FALSE
+"metabolomics","Pearson.est","estrogen receptor antagonist",0.35014,0.893,0.578,197,0.885,"clomifene, raloxifene",0.238072161579471,0.0530567293021746,FALSE
+"metabolomics","Pearson.est","FGFR inhibitor",-0.39904,-1.03,0.404,1146,0.712,"MK.2461, erdafitinib, lucitanib",0.393618634889395,0.147520006363144,FALSE
+"metabolomics","Pearson.est","FLT3 inhibitor",-0.31096,-0.808,0.684,1298,0.809,"midostaurin, lestaurtinib, ponatinib, gilteritinib",0.164943898279884,0.0920514783877277,FALSE
+"metabolomics","Pearson.est","glucocorticoid receptor agonist",0.62138,1.6,0.0757,513,0.543,"hydrocortisone, prednisolone, desonide, methylprednisolone, ciclesonide, fluticasone.propionate, dexamethasone.acetate, piretanide, halcinonide, triamcinolone.acetonide, fluocinolone.acetonide, rimexolone, flumethasone.pivalate, betamethasone, prednisolone.acetate, beclomethasone.dipropionate, difluprednate, triamcinolone",1.12090412049993,0.265200170411153,FALSE
+"metabolomics","Pearson.est","glutamate receptor antagonist",0.32341,0.839,0.652,88,0.958,"tiletamine, latrepirdine",0.18575240426808,0.0186344909214556,FALSE
+"metabolomics","Pearson.est","glycogen synthase kinase inhibitor",-0.34427,-0.886,0.571,1019,0.705,"LY2090314, kenpaullone, tideglusib, GSK.3.inhibitor.IX",0.243363891754152,0.151810883008601,FALSE
+"metabolomics","Pearson.est","growth factor receptor inhibitor",-0.49025,-1.28,0.19,1154,0.508,"AZD3463, GSK1838705A, lestaurtinib",0.721246399047171,0.294136287716081,FALSE
+"metabolomics","Pearson.est","HCV inhibitor",0.6066,1.58,0.0642,20,0.471,"PSI.7976, narlaprevir",1.19246497193115,0.326979092871104,FALSE
+"metabolomics","Pearson.est","HDAC inhibitor",-0.57671,-1.5,0.0885,1084,0.377,"AR.42, trichostatin.a, mocetinostat, givinostat, PCI.24781, SB.939, nexturastat.a, entinostat, dacinostat, M.344, belinostat, resminostat, panobinostat, R306465, JNJ.26481585, RG2833",1.05305672930217,0.423658649794207,FALSE
+"metabolomics","Pearson.est","histamine receptor antagonist",0.35525,0.9,0.559,225,0.907,"ranitidine, nizatidine, epinastine, terfenadine, famotidine",0.252588192113577,0.0423927129399047,FALSE
+"metabolomics","Pearson.est","HMGCR inhibitor",0.46066,1.21,0.239,14,0.591,"fluvastatin",0.621602099051862,0.228412519118745,FALSE
+"metabolomics","Pearson.est","HSP inhibitor",-0.37371,-0.958,0.48,1005,0.649,"KW.2478, ganetespib, BIIB021, SNX.5422, NVP.AUY922, VER.49009",0.318758762624413,0.187755303199631,FALSE
+"metabolomics","Pearson.est","JAK inhibitor",0.32284,0.831,0.676,223,0.938,"TG.101348, AZD1480, CEP.33779, WHI.P154, filgotinib",0.170053304058364,0.0277971616209356,FALSE
+"metabolomics","Pearson.est","KIT inhibitor",-0.54617,-1.36,0.135,1176,0.469,"sunitinib, vatalanib, dasatinib, telatinib, midostaurin, pazopanib, KI.8751, motesanib",0.869666231504994,0.328827157284917,FALSE
+"metabolomics","Pearson.est","MDM inhibitor",0.90559,2.37,0,105,0.000946,"idasanutlin, CGM097, nutlin.3, RITA, AMG.232",Inf,3.02410886359821,TRUE
+"metabolomics","Pearson.est","MEK inhibitor",-0.56892,-1.45,0.108,1164,0.428,"arctigenin, AS.703026, selumetinib, PD.184352, TAK.733, AZD8330, nobiletin, trametinib, BIX.02188, cobimetinib",0.96657624451305,0.368556230986828,FALSE
+"metabolomics","Pearson.est","MET inhibitor",-0.77872,-2.01,0.00197,1158,0.114,"PHA.665752, PF.04217903, LY2801653, NVP.BVU972, INC.280",2.70553377383841,0.943095148663527,TRUE
+"metabolomics","Pearson.est","microtubule inhibitor",0.2276,0.578,0.923,508,0.989,"cabazitaxel, vinblastine, colchicine, triclabendazole, secnidazole",0.0347982989740879,0.0048037084028206,FALSE
+"metabolomics","Pearson.est","mTOR inhibitor",-0.25175,-0.651,0.882,1275,0.939,"deforolimus, NVP.BEZ235, torin.2, everolimus, temsirolimus",0.0545314148681803,0.0273344077338891,FALSE
+"metabolomics","Pearson.est","NFkB pathway inhibitor",-0.29861,-0.76,0.734,1362,0.86,"bortezomib, Ro.106.9920",0.134303940083929,0.0655015487564323,FALSE
+"metabolomics","Pearson.est","opioid receptor agonist",-0.29281,-0.746,0.761,1320,0.86,"cebranopadol",0.118615343229427,0.0655015487564323,FALSE
+"metabolomics","Pearson.est","p38 MAPK inhibitor",0.50646,1.28,0.203,349,0.54,"talmapimod, SB.242235, skepinone.l",0.692503962086787,0.267606240177031,FALSE
+"metabolomics","Pearson.est","PARP inhibitor",-0.27739,-0.707,0.797,1072,0.891,"PJ.34, olaparib, talazoparib",0.0985416786038876,0.0501222959631252,FALSE
+"metabolomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45321,-1.18,0.249,1176,0.584,"sunitinib, vatalanib, dasatinib, telatinib, pazopanib, SU014813, KI.8751, motesanib, ponatinib",0.603800652904264,0.233587152887601,FALSE
+"metabolomics","Pearson.est","phosphatase inhibitor",0.31754,0.804,0.672,149,0.957,"bis.maltolato.oxovanadium.IV., GSK2830371",0.172630726946175,0.0190880622231565,FALSE
+"metabolomics","Pearson.est","phosphodiesterase inhibitor",-0.50864,-1.33,0.165,884,0.487,"EMD.53998, papaverine, GSK256066, trequinsin, YM.976, zardaverine",0.782516055786094,0.312471038785366,FALSE
+"metabolomics","Pearson.est","PI3K inhibitor",-0.17936,-0.467,0.992,877,0.989,"ZSTK.474, LY3023414, PI.828, taselisib, GSK2126458, buparlisib, BGT226, alpelisib, CH5132799, GDC.0980, CUDC.907, NVP.BEZ235, TG100.115",0.00348832784582135,0.0048037084028206,FALSE
+"metabolomics","Pearson.est","PLK inhibitor",0.30273,0.792,0.713,243,0.914,"HMN.214, NMS.1286937",0.146910470148134,0.0390538042661686,FALSE
+"metabolomics","Pearson.est","potassium channel blocker",-0.39294,-1.03,0.395,1223,0.712,"mepivacaine, dofetilide",0.40340290437354,0.147520006363144,FALSE
+"metabolomics","Pearson.est","PPAR receptor agonist",0.49432,1.29,0.19,588,0.563,"fenofibrate, pterostilbene, clofibrate, S26948, oleoylethanolamide",0.721246399047171,0.249491605148654,FALSE
+"metabolomics","Pearson.est","progesterone receptor agonist",0.4685,1.2,0.242,213,0.572,"norethindrone, levonorgestrel, norgestrel",0.616184634019569,0.242603971206976,FALSE
+"metabolomics","Pearson.est","proteasome inhibitor",-0.64676,-1.67,0.0296,1180,0.315,"ixazomib.citrate, bortezomib, carfilzomib",1.52870828894106,0.501689446210399,FALSE
+"metabolomics","Pearson.est","protein synthesis inhibitor",0.36366,0.945,0.485,360,0.889,"cycloheximide, mercaptopurine, bruceantin, clofoctol, harringtonine, anguidine, chloramphenicol.palmitate, tedizolid.phosphate",0.314258261397736,0.0510982390297863,FALSE
+"metabolomics","Pearson.est","protein tyrosine kinase inhibitor",-0.3705,-0.967,0.464,1101,0.676,"rheochrysidin, BMS.599626, AV.412, NVP.TAE226",0.333482019445119,0.170053304058364,FALSE
+"metabolomics","Pearson.est","RAF inhibitor",-0.72337,-1.88,0.0113,1040,0.193,"sorafenib, PLX.4720, CEP.32496, LGX818, SB.590885, GDC.0879, AZ.628, TAK.632, RAF265, dabrafenib, vemurafenib",1.94692155651658,0.714442690992226,TRUE
+"metabolomics","Pearson.est","RET tyrosine kinase inhibitor",-0.61902,-1.61,0.0568,907,0.277,"apatinib, sorafenib, vandetanib, sunitinib",1.24565166428898,0.557520230935551,FALSE
+"metabolomics","Pearson.est","retinoid receptor agonist",-0.36603,-0.965,0.483,1184,0.658,"CD.437, LE.135, tamibarotene, adarotene",0.316052869248488,0.181774106386044,FALSE
+"metabolomics","Pearson.est","ribonucleotide reductase inhibitor",-0.39033,-0.992,0.432,1151,0.729,"fludarabine, hydroxyurea, triapine, clofarabine",0.364516253185088,0.137272471682025,FALSE
+"metabolomics","Pearson.est","serotonin receptor agonist",0.57338,1.49,0.0861,2,0.438,"aripiprazole",1.06499684854635,0.3585258894959,FALSE
+"metabolomics","Pearson.est","serotonin receptor antagonist",0.37902,0.976,0.475,248,0.907,"aripiprazole, pirenperone, SB.200646, lurasidone",0.323306390375133,0.0423927129399047,FALSE
+"metabolomics","Pearson.est","sodium channel blocker",0.19062,0.489,0.983,404,0.983,"A.803467, cibenzoline, brivaracetam, butamben",0.00744648216786438,0.00744648216786438,FALSE
+"metabolomics","Pearson.est","src inhibitor",-0.5731,-1.5,0.0886,1112,0.377,"PP.2, dasatinib, PP.1, saracatinib, TG.100572",1.05256627811295,0.423658649794207,FALSE
+"metabolomics","Pearson.est","sterol demethylase inhibitor",0.66737,1.74,0.0285,442,0.327,"terconazole, ketoconazole, posaconazole, lanoconazole, chlormidazole",1.54515513999149,0.485452247339714,FALSE
+"metabolomics","Pearson.est","TGF beta receptor inhibitor",0.23797,0.623,0.91,367,0.976,"adaprev, SB.525334",0.0409586076789064,0.0105501823333082,FALSE
+"metabolomics","Pearson.est","thymidylate synthase inhibitor",-0.54377,-1.4,0.116,1139,0.437,"trifluridine, raltitrexed, capecitabine, doxifluridine",0.935542010773082,0.359518563029578,FALSE
+"metabolomics","Pearson.est","topoisomerase inhibitor",-0.54843,-1.43,0.11,1038,0.421,"beta.lapachone, licochalcone.a, fleroxacin, SN.38, teniposide, exatecan.mesylate, topotecan, doxorubicin, camptothecin, genz.644282, rubitecan, etoposide, daunorubicin, irinotecan",0.958607314841775,0.375717904164332,FALSE
+"metabolomics","Pearson.est","tubulin polymerization inhibitor",0.47583,1.21,0.237,438,0.591,"nocodazole, epothilone.b, indibulin, taltobulin, KX2.391, BNC105, flubendazole, dolastatin.10, vinorelbine, oxibendazole, mebendazole, vinblastine, ABT.751, verubulin, CYT.997, epothilone.d",0.625251653989896,0.228412519118745,FALSE
+"metabolomics","Pearson.est","tyrosine kinase inhibitor",-0.36147,-0.914,0.535,1040,0.699,"sorafenib, bafetinib, rheochrysidin, BMS.599626, AV.412, vandetanib, sunitinib, dasatinib, NVP.TAE226, tivantinib, hypericin",0.271646217978772,0.155522824254319,FALSE
+"metabolomics","Pearson.est","VEGFR inhibitor",-0.47051,-1.21,0.243,1037,0.565,"tivozanib, sorafenib, AEE788, BMS.690514, MK.2461, vandetanib, sunitinib, vatalanib, telatinib, RAF265, pazopanib, SU014813, KI.8751, lucitanib, motesanib, golvatinib, foretinib, TG.100572",0.614393726401688,0.247951552180562,FALSE
+"metabolomics","Pearson.est","vitamin D receptor agonist",-0.39669,-1.01,0.428,1137,0.723,"tacalcitol, calcitriol",0.368556230986828,0.140861702705469,FALSE
diff --git a/Examples/Fig4/DMEA/DMEA_venn_diagram.pdf b/Examples/Fig4/DMEA/DMEA_venn_diagram.pdf
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new file mode 100644
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--- /dev/null
+++ b/Examples/Fig4/GSEA/GSEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
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+</body>
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diff --git a/Examples/Fig4/GSEA/GSEA_mean_results.csv b/Examples/Fig4/GSEA/GSEA_mean_results.csv
new file mode 100644
index 0000000..82c7baf
--- /dev/null
+++ b/Examples/Fig4/GSEA/GSEA_mean_results.csv
@@ -0,0 +1,189 @@
+"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"KEGG_STEROID_BIOSYNTHESIS",1.915,0.162634559672906,0.00055771210444146,"transcriptomics, proteomics",2,0,"",0.0481248744140978
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",1.9,0.0424264068711927,0.00031063141532933,"transcriptomics, proteomics",2,0,"",0.0481248744140978
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",1.745,0.0212132034355964,0.000811093389001649,"transcriptomics, proteomics",2,0,"",0.0481248744140978
+"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",1.665,0.0353553390593274,0.00421214514840142,"transcriptomics, proteomics",2,0,"",0.180739850725518
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",1.64,0.0565685424949237,0.0052762844104609,"transcriptomics, proteomics",2,0,"",0.180739850725518
+"KEGG_SULFUR_METABOLISM",1.63,0.0424264068711927,0.00812313935845023,"transcriptomics, proteomics",2,0,"",0.180739850725518
+"KEGG_O_GLYCAN_BIOSYNTHESIS",1.55,0.183847763108502,0.0120637209774593,"transcriptomics, proteomics",2,0,"",0.238593592665305
+"KEGG_DORSO_VENTRAL_AXIS_FORMATION",1.44,0.226274169979695,0.0345737038844385,"transcriptomics, proteomics",2,0,"",0.426452007796741
+"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",1.425,0.304055915910215,0.0394053318733899,"transcriptomics, proteomics",2,0,"",0.438384317091462
+"KEGG_THYROID_CANCER",1.37,0.339411254969543,0.0584786388133658,"transcriptomics, proteomics",2,0,"",0.47314535039905
+"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",1.335,0.37476659402887,0.0890930714912518,"transcriptomics, proteomics",2,0,"",0.553258940853094
+"KEGG_PENTOSE_PHOSPHATE_PATHWAY",1.335,0.0777817459305201,0.0738898001096948,"transcriptomics, proteomics",2,0,"",0.530934219074224
+"KEGG_CIRCADIAN_RHYTHM_MAMMAL",1.325,0.176776695296637,0.0945209125644261,"transcriptomics, proteomics",2,0,"",0.555495584209551
+"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",1.325,0.162634559672906,0.0745694127913236,"transcriptomics, proteomics",2,0,"",0.530934219074224
+"KEGG_AXON_GUIDANCE",1.32,0.014142135623731,0.0583629485697244,"transcriptomics, proteomics",2,0,"",0.47314535039905
+"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",1.32,0.15556349186104,0.0867528881197107,"transcriptomics, proteomics",2,0,"",0.553258940853094
+"KEGG_VEGF_SIGNALING_PATHWAY",1.3,0.29698484809835,0.0901376926108973,"transcriptomics, proteomics",2,0,"",0.553258940853094
+"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",1.3,0.226274169979695,0.109226659816485,"transcriptomics, proteomics",2,0,"",0.555495584209551
+"KEGG_STARCH_AND_SUCROSE_METABOLISM",1.285,0.00707106781186548,0.0850094468556923,"transcriptomics, proteomics",2,0,"",0.553258940853094
+"KEGG_TIGHT_JUNCTION",1.2815,0.450427019615831,0.107110659791508,"transcriptomics, proteomics",2,0,"",0.555495584209551
+"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",1.275,0.0212132034355964,0.113926575335333,"transcriptomics, proteomics",2,0,"",0.563303622491369
+"KEGG_GALACTOSE_METABOLISM",1.2565,0.37264527368531,0.0717096362661234,"transcriptomics, proteomics",2,0,"",0.530934219074224
+"KEGG_ETHER_LIPID_METABOLISM",1.245,0.162634559672906,0.128161900669198,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",1.24,0.212132034355964,0.129715127102377,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_ARACHIDONIC_ACID_METABOLISM",1.23,0.14142135623731,0.143446909799351,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_CELL_ADHESION_MOLECULES_CAMS",1.225,0.205060966544099,0.155805455498562,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_N_GLYCAN_BIOSYNTHESIS",1.225,0.134350288425444,0.151394455592676,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_BLADDER_CANCER",1.21,0.127279220613579,0.159654976029578,"transcriptomics, proteomics",2,0,"",0.590256897648492
+"KEGG_ECM_RECEPTOR_INTERACTION",1.18,0.0565685424949239,0.198123897439501,"transcriptomics, proteomics",2,0,"",0.608035409383296
+"KEGG_PPAR_SIGNALING_PATHWAY",1.175,0.0353553390593274,0.1874606134089,"transcriptomics, proteomics",2,0,"",0.600085190357811
+"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",1.1735,0.249608693758851,0.140888956147711,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_ADHERENS_JUNCTION",1.17,0.183847763108502,0.209260939218247,"transcriptomics, proteomics",2,0,"",0.611400535497208
+"KEGG_ERBB_SIGNALING_PATHWAY",1.165,0.00707106781186548,0.209524902614212,"transcriptomics, proteomics",2,0,"",0.611400535497208
+"KEGG_FOLATE_BIOSYNTHESIS",1.155,0.106066017177982,0.203889978860639,"transcriptomics, proteomics",2,0,"",0.611400535497208
+"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",1.1545,0.248194480196478,0.257852512459703,"transcriptomics, proteomics",2,0,"",0.665184742287349
+"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",1.146,0.41577878733769,0.226605090532601,"transcriptomics, proteomics",2,0,"",0.625799339658275
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",1.1405,0.267993470069702,0.193912173985747,"transcriptomics, proteomics",2,0,"",0.605550297709875
+"KEGG_LEISHMANIA_INFECTION",1.135,0.134350288425444,0.233992352735262,"transcriptomics, proteomics",2,0,"",0.625799339658275
+"KEGG_ACUTE_MYELOID_LEUKEMIA",1.13,0.0989949493661166,0.285903104540908,"transcriptomics, proteomics",2,0,"",0.716771163496924
+"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",1.127,0.499217387517703,0.145440160415175,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_TYROSINE_METABOLISM",1.116,0.41577878733769,0.188790846404705,"transcriptomics, proteomics",2,0,"",0.600085190357811
+"KEGG_MTOR_SIGNALING_PATHWAY",1.11,0.0989949493661166,0.296030455829575,"transcriptomics, proteomics",2,0,"",0.728145603869248
+"KEGG_LYSOSOME",1.1095,0.580534667354156,0.141898091288192,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",1.0975,0.159099025766973,0.332404775512872,"transcriptomics, proteomics",2,0,"",0.732061172491496
+"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",1.09,0.0989949493661166,0.306830673370159,"transcriptomics, proteomics",2,0,"",0.72821146479851
+"KEGG_ENDOMETRIAL_CANCER",1.089,0.453962553521763,0.30183793672628,"transcriptomics, proteomics",2,0,"",0.728145603869248
+"KEGG_PEROXISOME",1.0835,0.207182286887658,0.279584664417728,"transcriptomics, proteomics",2,0,"",0.710943860947936
+"KEGG_NON_SMALL_CELL_LUNG_CANCER",1.076,0.11879393923934,0.364407680677363,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_RIBOFLAVIN_METABOLISM",1.0705,0.338704148188356,0.333128960515793,"transcriptomics, proteomics",2,0,"",0.732061172491496
+"KEGG_RENAL_CELL_CARCINOMA",1.065,0.0212132034355964,0.389403230616191,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_PANCREATIC_CANCER",1.06,0.0848528137423858,0.385761330008228,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_NOTCH_SIGNALING_PATHWAY",1.0535,0.136471608769004,0.369216078060731,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",1.05,0.424264068711929,0.351741911336706,"transcriptomics, proteomics",2,0,"",0.745357859737305
+"KEGG_ENDOCYTOSIS",1.0225,0.265165042944955,0.407078220376932,"transcriptomics, proteomics",2,0,"",0.762736033969409
+"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",1.0055,0.0770746391493338,0.474250613817934,"transcriptomics, proteomics",2,0,"",0.827613816270512
+"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",1.0055,0.0770746391493338,0.487742068477896,"transcriptomics, proteomics",2,0,"",0.829046469072016
+"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.992,0.39315137033972,0.347690379635031,"transcriptomics, proteomics",2,0,"",0.745357859737305
+"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.988,0.158391918985787,0.48904426546383,"transcriptomics, proteomics",2,0,"",0.829046469072016
+"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.983,0.420021428024809,0.347137440047844,"transcriptomics, proteomics",2,0,"",0.745357859737305
+"KEGG_FATTY_ACID_METABOLISM",0.9765,0.174655374953077,0.510563360843721,"transcriptomics, proteomics",2,0,"",0.857361115379079
+"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.971,0.394565583902094,0.39624785781463,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.964,0.347896536343781,0.481212223462171,"transcriptomics, proteomics",2,0,"",0.829046469072016
+"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.9555,0.204353859762912,0.546053230299415,"transcriptomics, proteomics",2,0,"",0.874599746975749
+"KEGG_MELANOGENESIS",0.9555,0.133643181644258,0.586520136773377,"transcriptomics, proteomics",2,0,"",0.892312686715052
+"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.95,0.254558441227157,0.562958780572096,"transcriptomics, proteomics",2,0,"",0.878681262636279
+"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.949,0.0480832611206852,0.634661344847042,"transcriptomics, proteomics",2,0,"",0.916382649201493
+"KEGG_VIRAL_MYOCARDITIS",0.943,0.264457936163769,0.567687332602091,"transcriptomics, proteomics",2,0,"",0.878681262636279
+"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.9275,0.0544472221513641,0.654396998642311,"transcriptomics, proteomics",2,0,"",0.91718634455379
+"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.9085,0.440527524679219,0.440747446510298,"transcriptomics, proteomics",2,0,"",0.807750180477686
+"KEGG_TASTE_TRANSDUCTION",0.8995,0.340118361750729,0.618154880615334,"transcriptomics, proteomics",2,0,"",0.909725896380489
+"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.896,0.131521861300698,0.709487426199479,"transcriptomics, proteomics",2,0,"",0.949805233530186
+"KEGG_GLUTATHIONE_METABOLISM",0.8855,0.123743686707646,0.725942755947498,"transcriptomics, proteomics",2,0,"",0.951106901972484
+"KEGG_JAK_STAT_SIGNALING_PATHWAY",0.8785,0.140714249456123,0.726688419484595,"transcriptomics, proteomics",2,0,"",0.951106901972484
+"KEGG_FOCAL_ADHESION",0.86,0.0410121933088198,0.78532034706412,"transcriptomics, proteomics",2,0,"",0.970816423820948
+"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.8525,0.0643467170879758,0.797906039471933,"transcriptomics, proteomics",2,0,"",0.970816423820948
+"KEGG_PROSTATE_CANCER",0.8485,0.0855599205235723,0.801741653380221,"transcriptomics, proteomics",2,0,"",0.970816423820948
+"KEGG_SMALL_CELL_LUNG_CANCER",0.8445,0.0643467170879758,0.795997237838954,"transcriptomics, proteomics",2,0,"",0.970816423820948
+"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.84,0.0791959594928933,0.809906000764379,"transcriptomics, proteomics",2,0,"",0.973244413340943
+"KEGG_GNRH_SIGNALING_PATHWAY",0.8355,0.246780266634105,0.753263211521839,"transcriptomics, proteomics",2,0,"",0.961156905625959
+"KEGG_BUTANOATE_METABOLISM",0.8305,0.0162634559672906,0.850989357851896,"transcriptomics, proteomics",2,0,"",0.979213819695412
+"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.8285,0.129400540957138,0.820901027609806,"transcriptomics, proteomics",2,0,"",0.97413588609697
+"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.8165,0.0912167747730646,0.858187392542046,"transcriptomics, proteomics",2,0,"",0.979213819695412
+"KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.807,0.104651803615609,0.885246645185309,"transcriptomics, proteomics",2,0,"",0.982927589918995
+"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.7945,0.00212132034355964,0.891064262513035,"transcriptomics, proteomics",2,0,"",0.982927589918995
+"KEGG_CALCIUM_SIGNALING_PATHWAY",0.7825,0.127986327394765,0.894574548128524,"transcriptomics, proteomics",2,0,"",0.982927589918995
+"KEGG_WNT_SIGNALING_PATHWAY",0.7815,0.0700035713374682,0.90801631684201,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_SPHINGOLIPID_METABOLISM",0.7745,0.0827314933988261,0.908588382654003,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.7735,0.0530330085889911,0.924058929402915,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.7625,0.420728534805996,0.692903340982458,"transcriptomics, proteomics",2,0,"",0.948744574575981
+"KEGG_INSULIN_SIGNALING_PATHWAY",0.7585,0.263750829382582,0.856018223472532,"transcriptomics, proteomics",2,0,"",0.979213819695412
+"KEGG_PATHWAYS_IN_CANCER",0.754,0.104651803615609,0.9351160353012,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_APOPTOSIS",0.744,0.103237590053236,0.951071607226839,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_VIBRIO_CHOLERAE_INFECTION",0.7205,0.437699097554473,0.776445608503706,"transcriptomics, proteomics",2,0,"",0.970816423820948
+"KEGG_GLYCEROLIPID_METABOLISM",0.718,0.282842712474619,0.865811452714908,"transcriptomics, proteomics",2,0,"",0.981620627918812
+"KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.712,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_P53_SIGNALING_PATHWAY",0.6985,0.195868578388674,0.938536809293395,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_LONG_TERM_POTENTIATION",0.6835,0.00919238815542505,0.979371244204903,"transcriptomics, proteomics",2,0,"",0.992826766145126
+"KEGG_CHRONIC_MYELOID_LEUKEMIA",0.682,0.0296984848098349,0.983600437439118,"transcriptomics, proteomics",2,0,"",0.992826766145126
+"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.682,0.239002092041053,0.952779173344589,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.672,0.15980613254816,0.963707881249188,"transcriptomics, proteomics",2,0,"",0.988350836763138
+"KEGG_OTHER_GLYCAN_DEGRADATION",0.566,1.68857099347348,0.0331587967106251,"transcriptomics, proteomics",2,0,"",0.426452007796741
+"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.3375,1.57331258814007,0.174899430526967,"transcriptomics, proteomics",2,0,"",0.594293952112485
+"KEGG_PRIMARY_IMMUNODEFICIENCY",0.3365,1.84342737855333,0.0420378000119916,"transcriptomics, proteomics",2,0,"",0.438866716338083
+"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.283,1.38168665043851,0.460473884443628,"transcriptomics, proteomics",2,0,"",0.81799651745086
+"KEGG_TYPE_I_DIABETES_MELLITUS",0.2295,1.44320494040174,0.392840466980235,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_BASAL_CELL_CARCINOMA",0.17,1.28693434175952,0.608017997416452,"transcriptomics, proteomics",2,0,"",0.909472298656541
+"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.165,2.05768073325285,0.0158751331920396,"transcriptomics, proteomics",2,0,"",0.282577370818305
+"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.1525,0.976514464818622,0.95079912270602,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.133,1.59381868479448,0.23906941065597,"transcriptomics, proteomics",2,0,"",0.625799339658275
+"KEGG_COLORECTAL_CANCER",0.126,1.09601551083915,0.884649066318332,"transcriptomics, proteomics",2,0,"",0.982927589918995
+"KEGG_PROPANOATE_METABOLISM",0.122,1.28410591463477,0.638378924162838,"transcriptomics, proteomics",2,0,"",0.916382649201493
+"KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.0835,1.50825876427091,0.328251464745458,"transcriptomics, proteomics",2,0,"",0.732061172491496
+"KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.082,1.36895872837716,0.529397143258659,"transcriptomics, proteomics",2,0,"",0.872524921296678
+"KEGG_BASE_EXCISION_REPAIR",0.0775,1.15470537367763,0.875267785019435,"transcriptomics, proteomics",2,0,"",0.982927589918995
+"KEGG_TYPE_II_DIABETES_MELLITUS",0.0615,1.38380797078207,0.516223744567709,"transcriptomics, proteomics",2,0,"",0.858764733953759
+"KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.059,1.22188051789035,0.774683866540996,"transcriptomics, proteomics",2,0,"",0.970816423820948
+"KEGG_MISMATCH_REPAIR",0.055,1.68998520703585,0.182874445524158,"transcriptomics, proteomics",2,0,"",0.600085190357811
+"KEGG_RETINOL_METABOLISM",0.04,1.71119841047145,0.155369887641028,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.03,1.81019335983756,0.103946070486637,"transcriptomics, proteomics",2,0,"",0.555495584209551
+"KEGG_LONG_TERM_DEPRESSION",0.0205,0.956715474945399,0.988131336819642,"transcriptomics, proteomics",2,0,"",0.992826766145126
+"KEGG_SELENOAMINO_ACID_METABOLISM",0.0115,1.02035508525219,0.966140705599922,"transcriptomics, proteomics",2,0,"",0.988350836763138
+"KEGG_HISTIDINE_METABOLISM",0.005,1.43542676580869,0.444716391498951,"transcriptomics, proteomics",2,0,"",0.807750180477686
+"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.0035,1.27774195360409,0.713480749187654,"transcriptomics, proteomics",2,0,"",0.949805233530186
+"KEGG_DILATED_CARDIOMYOPATHY",-0.004,1.23036579926459,0.7506534782875,"transcriptomics, proteomics",2,0,"",0.961156905625959
+"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.0045,1.19430335342408,0.814682121279779,"transcriptomics, proteomics",2,0,"",0.973244413340943
+"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.00750000000000001,0.886004796826744,0.992826766145126,"transcriptomics, proteomics",2,0,"",0.992826766145126
+"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.025,1.68998520703585,0.215820784606351,"transcriptomics, proteomics",2,0,"",0.61961451064404
+"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.03,1.30956175875749,0.652259231843655,"transcriptomics, proteomics",2,0,"",0.91718634455379
+"KEGG_ALZHEIMERS_DISEASE",-0.038,1.04934646328084,0.948510046683055,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_MAPK_SIGNALING_PATHWAY",-0.0545,1.16743329573899,0.830196034913158,"transcriptomics, proteomics",2,0,"",0.978641683540014
+"KEGG_PHENYLALANINE_METABOLISM",-0.055,1.74655374953077,0.153432310043954,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.075,1.36471608769004,0.545366449520804,"transcriptomics, proteomics",2,0,"",0.874599746975749
+"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.0855,1.29188408922782,0.690482909107846,"transcriptomics, proteomics",2,0,"",0.948744574575981
+"KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.095,1.71826947828331,0.174886742653429,"transcriptomics, proteomics",2,0,"",0.594293952112485
+"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.1,1.14834141264695,0.840832817795071,"transcriptomics, proteomics",2,0,"",0.979213819695412
+"KEGG_GLIOMA",-0.105,1.23178001282697,0.715021917376657,"transcriptomics, proteomics",2,0,"",0.949805233530186
+"KEGG_NITROGEN_METABOLISM",-0.1175,1.47431763877395,0.391740954545974,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.145,1.95868578388674,0.0548694731667342,"transcriptomics, proteomics",2,0,"",0.47314535039905
+"KEGG_PROTEASOME",-0.149,1.33077496219308,0.578308515992854,"transcriptomics, proteomics",2,0,"",0.887404446954553
+"KEGG_OOCYTE_MEIOSIS",-0.1575,1.01611244456507,0.923793030318454,"transcriptomics, proteomics",2,0,"",0.986015656135679
+"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.159,1.50048058967785,0.387136131950925,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_OLFACTORY_TRANSDUCTION",-0.1695,1.25935717729324,0.650646623296866,"transcriptomics, proteomics",2,0,"",0.91718634455379
+"KEGG_PYRUVATE_METABOLISM",-0.1745,1.1405632380539,0.733120021655323,"transcriptomics, proteomics",2,0,"",0.952520904048521
+"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.182,1.62351716960431,0.234331755876882,"transcriptomics, proteomics",2,0,"",0.625799339658275
+"KEGG_TRYPTOPHAN_METABOLISM",-0.1895,1.3300678554119,0.552820334840267,"transcriptomics, proteomics",2,0,"",0.874599746975749
+"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.1965,1.26359981798036,0.594847331157008,"transcriptomics, proteomics",2,0,"",0.897312075813115
+"KEGG_LYSINE_DEGRADATION",-0.2075,1.21975919754679,0.674265494130077,"transcriptomics, proteomics",2,0,"",0.937650452774638
+"KEGG_HOMOLOGOUS_RECOMBINATION",-0.2245,1.28057038072884,0.62320171901604,"transcriptomics, proteomics",2,0,"",0.909725896380489
+"KEGG_LINOLEIC_ACID_METABOLISM",-0.255,2.01525432638166,0.0443797803038511,"transcriptomics, proteomics",2,0,"",0.438866716338083
+"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.292,1.69422784772297,0.162486449352675,"transcriptomics, proteomics",2,0,"",0.590256897648492
+"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.3195,1.52805775414413,0.302712217338901,"transcriptomics, proteomics",2,0,"",0.728145603869248
+"KEGG_OXIDATIVE_PHOSPHORYLATION",-0.341,1.42694148443445,0.396290620148162,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_CELL_CYCLE",-0.3625,1.24097240098239,0.456905790890463,"transcriptomics, proteomics",2,0,"",0.81799651745086
+"KEGG_ABC_TRANSPORTERS",-0.472,1.62351716960431,0.228905352431052,"transcriptomics, proteomics",2,0,"",0.625799339658275
+"KEGG_PRION_DISEASES",-0.546,1.77342380721586,0.124076527294908,"transcriptomics, proteomics",2,0,"",0.590071725079659
+"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.6225,1.53795724908074,0.176952693606526,"transcriptomics, proteomics",2,1,"transcriptomics",0.594293952112485
+"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.692,2.06192337393997,NA,"transcriptomics, proteomics",2,0,"",NA
+"KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.725,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_PYRIMIDINE_METABOLISM",-0.765,0.222031529292576,0.856764603936648,"transcriptomics, proteomics",2,0,"",0.979213819695412
+"KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.779,0.354967604155647,0.698751888222322,"transcriptomics, proteomics",2,0,"",0.949449130561628
+"KEGG_ALLOGRAFT_REJECTION",-0.792,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_HUNTINGTONS_DISEASE",-0.81,0.311126983722081,0.755966105548507,"transcriptomics, proteomics",2,0,"",0.961156905625959
+"KEGG_BETA_ALANINE_METABOLISM",-0.8465,0.0190918830920368,0.793025263248264,"transcriptomics, proteomics",2,0,"",0.970816423820948
+"KEGG_GAP_JUNCTION",-0.8705,0.381130555059549,0.623519996395616,"transcriptomics, proteomics",2,0,"",0.909725896380489
+"KEGG_PURINE_METABOLISM",-0.926,0.231931024229188,0.541035485839175,"transcriptomics, proteomics",2,0,"",0.874599746975749
+"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.965,0.289913780286484,0.555223434877863,"transcriptomics, proteomics",2,0,"",0.874599746975749
+"KEGG_REGULATION_OF_AUTOPHAGY",-0.987,0.386080302527855,0.434180846473036,"transcriptomics, proteomics",2,0,"",0.805043652835421
+"KEGG_PARKINSONS_DISEASE",-1.002,0.562856997824492,0.332556110976229,"transcriptomics, proteomics",2,0,"",0.732061172491496
+"KEGG_TGF_BETA_SIGNALING_PATHWAY",-1.002,0.350724963468528,0.464144091362567,"transcriptomics, proteomics",2,0,"",0.81799651745086
+"KEGG_MELANOMA",-1.064,0.277185858225127,0.33173012011406,"transcriptomics, proteomics",2,0,"",0.732061172491496
+"KEGG_PROTEIN_EXPORT",-1.065,0.0494974746830584,0.368174607026404,"transcriptomics, proteomics",2,0,"",0.750422663684818
+"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-1.078,0.469518902707868,0.322259057146716,"transcriptomics, proteomics",2,0,"",0.732061172491496
+"KEGG_SPLICEOSOME",-1.149,0.227688383542068,0.235750750134503,"transcriptomics, proteomics",2,0,"",0.625799339658275
+"KEGG_ASTHMA",-1.16,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_DNA_REPLICATION",-1.1605,0.777110352524016,0.0563535863250453,"transcriptomics, proteomics",2,1,"transcriptomics",0.47314535039905
+"KEGG_BASAL_TRANSCRIPTION_FACTORS",-1.22,0.0848528137423858,0.171110994218738,"transcriptomics, proteomics",2,0,"",0.594293952112485
+"KEGG_RNA_POLYMERASE",-1.27,0.0424264068711929,0.107893163959754,"transcriptomics, proteomics",2,0,"",0.555495584209551
+"KEGG_RNA_DEGRADATION",-1.325,0.0494974746830584,0.0972608853057914,"transcriptomics, proteomics",2,0,"",0.555495584209551
+"acyl carnitines",-1.39,NA,NA,"metabolomics",1,0,"",NA
+"alpha amino acids",-1.45,NA,NA,"metabolomics",1,0,"",NA
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-1.47,0.707106781186548,NA,"transcriptomics, proteomics",2,1,"transcriptomics",NA
+"KEGG_AUTOIMMUNE_THYROID_DISEASE",-1.49,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_ONE_CARBON_POOL_BY_FOLATE",-1.53,0.0565685424949239,0.0274249110402645,"transcriptomics, proteomics",2,0,"",0.406802847097256
+"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-1.545,0.572756492761104,0.0359369669491636,"transcriptomics, proteomics",2,1,"transcriptomics",0.426452007796741
+"KEGG_RIBOSOME",-1.545,0.162634559672906,0.0240283272952428,"transcriptomics, proteomics",2,0,"",0.388822023504839
+"KEGG_LIMONENE_AND_PINENE_DEGRADATION",-1.75,0.339411254969543,0.00715622538740946,"transcriptomics, proteomics",2,1,"proteomics",0.180739850725518
+"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-1.82,0,0.00721180421517597,"transcriptomics, proteomics",2,1,"transcriptomics",0.180739850725518
+"KEGG_NON_HOMOLOGOUS_END_JOINING",-2.055,0.0494974746830582,NA,"transcriptomics, proteomics",2,1,"proteomics",NA
diff --git a/Examples/Fig4/GSEA/GSEA_results.csv b/Examples/Fig4/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..ead47b5
--- /dev/null
+++ b/Examples/Fig4/GSEA/GSEA_results.csv
@@ -0,0 +1,370 @@
+"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"transcriptomics","Log2FC","KEGG_ABC_TRANSPORTERS",0.23561,0.676,0.941,7191,0.988,"ABCA12, ABCB8, ABCB9, ABCA13, ABCD1, ABCC3, ABCA1, ABCA2, ABCB11, ABCC10, ABCD4, ABCA4, ABCC5, ABCA5, TAP2, ABCC11, ABCG1, ABCB6, ABCG2",0.0264103765727431,0.00524305541237188,FALSE
+"transcriptomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36169,1.06,0.344,5916,0.767,"PIK3R2, IKBKB, MAPK3, RPS6KB2, PML, RARA, PIK3CA, JUP, STAT5B, STAT3, BRAF, RELA, TCF7L1, RUNX1, BAD, PIM1, PIK3R3, CCNA1, STAT5A, MAPK1, PIK3R5, PIK3CB, CEBPA",0.46344155742847,0.115204636051019,FALSE
+"transcriptomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.36058,1.04,0.372,3562,0.764,"NECTIN1, CTNND1, CDH1, ERBB2, BAIAP2, NECTIN4, PTPN1, RAC2, MAPK3, INSR, PTPN6, SNAI2, MET, IGF1R, EP300, EGFR, PTPRF, TCF7L1, PTPRB, SRC",0.429457060118102,0.11690664142431,FALSE
+"transcriptomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.27558,0.807,0.773,5975,1,"TRADD, RXRA, CPT1B, PPARA, IKBKB, ACSL1, RXRB, CPT1C, ADIPOR1, IRS2, STAT3, PRKAA1, RELA, ACSL3, PRKAG2, PRKAB2, ACSL5, ACSL6, SLC2A1, MAPK10, IRS1, NFKBIA",0.111820506081675,0,FALSE
+"transcriptomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.44972,1.28,0.121,3496,0.78,"GLUL, AGXT, GLS2, ASL, ABAT, ASS1, GPT, NIT2, IL4I1",0.91721462968355,0.10790539730952,FALSE
+"transcriptomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.37286,1.07,0.347,5894,0.783,"PIK3R2, SCNN1A, MAPK3, INSR, PIK3CA, SFN, SCNN1G, IRS2, NEDD4L, PIK3R3, SCNN1B, HSD11B2, MAPK1, PIK3R5, IRS1, PIK3CB",0.459670525209126,0.106238237942057,FALSE
+"transcriptomics","Log2FC","KEGG_ALLOGRAFT_REJECTION",-0.23407,-0.792,0.762,16990,1,"PRF1, IL5",0.1180450286604,0,FALSE
+"transcriptomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.40981,1.21,0.181,3971,0.676,"PLA2G12A, PLA2G6, PLA2G4B, PLA2G10, PLA2G4E, ACOX1, PLA2G2C",0.742321425130815,0.170053304058364,FALSE
+"transcriptomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",0.24418,0.704,0.918,6624,0.998,"NDUFV1, CAPN1, CACNA1D, GRIN1, ATP2A3, CALML3, COX5B, LRP1, ATP5F1E, NDUFB7, MAPK3, CDK5, FADD, NDUFS8, EIF2AK3, NDUFA3, NDUFV2, COX6C, UQCR10, GRIN2A, APH1A, COX6B2, GRIN2D, CHP1, PPP3CA, SDHD, ADAM10, BAD, UQCR11, GNAQ, NDUFB4, NDUFAB1, APOE, CALML6, UQCRB, BACE2, NDUFA6, UQCRHL, ITPR3, NDUFA5, UQCRC1, NDUFB5, BID, MAPK1, CACNA1F, UQCRFS1, UQCRC2, PLCB3, COX6A1, GSK3B, NDUFA2, SNCA, APP, ERN1, CAPN2, ATP5PD, GRIN2C, NOS1, CHP2",0.0371573187987575,0.000869458712628891,FALSE
+"transcriptomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.55987,-1.95,0.022,17343,0.143,"IARS2, MARS2, FARS2, FARSB, WARS2, RARS2, PSTK, YARS2",1.65757731917779,0.844663962534938,TRUE
+"transcriptomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51252,1.48,0.0432,5085,0.535,"HK2, MPI, GMPPA, NANP, GCK, PGM1, GMPPB, NPL, NAGK, GALT, CYB5R1, NANS, FPGT, HK1, GALE, UXS1, CYB5R3, HEXB, GNPDA1, AMDHD2, PGM2",1.36451625318509,0.271646217978772,FALSE
+"transcriptomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28452,0.828,0.751,4515,0.999,"CAT, CCS, CASP1, MAPK13, GRIN1, GRIN2A, GPX1, GRIN2D, CHP1, MAPK11, PPP3CA, BAD, MAP3K5",0.124360062995832,0.000434511774017692,FALSE
+"transcriptomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26803,0.784,0.802,4719,1,"RFXANK, IFI30, TAPBP, CALR, CD74, CTSS, LGMN, CTSB, HSPA1B, B2M, CIITA, PDIA3, PSME1, CD4",0.0958256317158365,0,FALSE
+"transcriptomics","Log2FC","KEGG_APOPTOSIS",0.28433,0.817,0.766,6624,1,"TRADD, IL1RAP, CAPN1, PIK3R2, ENDOD1, IKBKB, PIK3CA, MYD88, FADD, TNFSF10, CASP10, RELA, CHP1, PPP3CA, IRAK4, BAD, ENDOG, PIK3R3, NGF, PRKACA, IL1A, BID, CSF2RB, BAX, PIK3R5, PIK3CB, IL1R1, NFKBIA, PRKAR1B, DFFA, CAPN2, BCL2L1, CHP2",0.115771230367396,0,FALSE
+"transcriptomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.38876,1.13,0.251,2694,0.705,"PLA2G12A, CYP4F3, CYP2E1, PTGES, PLA2G6, GGT7, PLA2G4B, LTC4S, PTGES2, EPHX2, CYP2J2, CYP4A22, PTGS1, PLA2G10, PLA2G4E, ALOX12B",0.600326278518962,0.151810883008601,FALSE
+"transcriptomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31866,0.915,0.607,5717,0.954,"GLUL, PYCR3, CKMT1A, CKMT1B, SAT2, NOS3, GLS2, ASL, ASS1, OAT, GATM, P4HA2, NAGS, PRODH, P4HA1, MAOA, AZIN2, ALDH4A1, GAMT",0.216811308924742,0.0204516252959049,FALSE
+"transcriptomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.3651,1.06,0.349,3482,0.767,"ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, JUP, DSP, ITGA3, CACNB2, DAG1, DSG2, ITGA2B, DSC2, TCF7L1, PKP2",0.45717457304082,0.115204636051019,FALSE
+"transcriptomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.50501,-1.82,0.0375,14596,0.175,"UGDH, MIOX, ALDH3A2, UGT2A1, ALDH1B1, ALDH7A1, ALDH9A1",1.42596873227228,0.756961951313706,TRUE
+"transcriptomics","Log2FC","KEGG_ASTHMA",-0.34369,-1.16,0.262,17122,0.594,"IL13, EPX, IL5",0.581698708680255,0.226213555018806,FALSE
+"transcriptomics","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.42092,-1.49,0.0682,16806,0.282,"IFNA21, PRF1, IFNA13, IL5, CTLA4",1.16621562534352,0.549750891680639,FALSE
+"transcriptomics","Log2FC","KEGG_AXON_GUIDANCE",0.44776,1.31,0.0991,5666,0.806,"EPHA1, PAK6, PLXNB2, EPHB3, PLXNB1, PLXNA3, SEMA4A, EFNA1, FES, SEMA3E, EFNA4, SEMA4B, RAC2, LIMK2, SEMA7A, EFNA3, SRGAP3, MAPK3, NTN4, RHOD, UNC5B, NTN1, PLXNB3, CDK5, EPHB4, MET, PLXNA2, EPHB6, SEMA3B, ABLIM3, NCK2, EPHB2, SEMA4F, SRGAP1, UNC5A, ABLIM2, EFNB3, EFNB1, ABLIM1, SEMA5B, CHP1, PPP3CA, PAK2, SEMA4C, SEMA4D, NGEF, SEMA3C, LIMK1, NCK1, SEMA5A, RASA1, RND1, ROBO3, RAC1, PAK1, PAK4, MAPK1, NFATC1",1.00392634551472,0.0936649581949093,FALSE
+"transcriptomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.3741,1.08,0.317,4115,0.763,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, WNT4, DVL3, BMP2, WNT10A, GLI3, TCF7L1, FZD4, DVL2, WNT11",0.498940737782249,0.11747546204512,FALSE
+"transcriptomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36638,-1.28,0.146,18395,0.433,"TBPL1, TAF9B, TBP, GTF2H2, TAF9, TAF1L",0.835647144215563,0.363512103646635,FALSE
+"transcriptomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",0.30931,0.894,0.647,912,0.962,"SMUG1, POLD4, POLB",0.1890957193313,0.0168249279621871,FALSE
+"transcriptomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.24897,-0.86,0.67,17472,0.952,"ALDH1B1, ALDH7A1, SMS, ALDH9A1",0.173925197299174,0.0213630516155257,FALSE
+"transcriptomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.30636,0.89,0.634,3986,0.964,"ACOT4, TECR, ACAA1, ELOVL6, ACOX1, SCD5",0.197910742118267,0.0159229660971692,FALSE
+"transcriptomics","Log2FC","KEGG_BLADDER_CANCER",0.38783,1.12,0.262,4516,0.711,"CDH1, ERBB2, MMP9, TYMP, VEGFB, MAPK3, EGFR, E2F1, DAPK1, THBS1, FGFR3, BRAF, PGF, VEGFA, DAPK2",0.581698708680255,0.148130399270234,FALSE
+"transcriptomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.28276,0.819,0.765,2472,1,"ABAT, HMGCL, BDH1, HMGCS1, ACADS, EHHADH",0.116338564846382,0,FALSE
+"transcriptomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39615,1.14,0.249,6959,0.728,"VAV1, BLNK, PIK3R2, PLCG2, DAPP1, RAC2, VAV3, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, IFITM1, CD72, CD79A, RELA, CD19, CHP1, PPP3CA, LYN, PIK3R3, RAC1, MAPK1, NFATC1, PIK3R5, PIK3AP1, PIK3CB, NFKBIA, GSK3B, FOS, SYK, NFATC4, GRB2, CHP2, INPP5D, BCL10, CD22",0.603800652904264,0.137868620686963,FALSE
+"transcriptomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.29926,0.873,0.66,4406,0.969,"DRD5, PTAFR, BDKRB2, ERBB2, P2RX4, PLCG2, GNA15, CACNA1D, ERBB3, GRIN1, PLCD1, ATP2A3, CALML3, NOS3, CAMK2G, ADORA2B, ADORA2A, CACNA1I, ADCY4, BDKRB1, RYR1, PTK2B, EGFR, ATP2B4, SLC8A2, GRIN2A, PLCG1, SPHK2, PHKG1, ADRB2, GRIN2D, CHP1, P2RX6, PPP3CA, EDNRA, TNNC1, GNAS, GNAQ, P2RX2, LTB4R2, HTR7",0.180456064458131,0.0136762229492347,FALSE
+"transcriptomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27818,0.803,0.804,6162,1,"TNNI3, CACNA1D, CACNG1, COX5B, CACNB3, CACNG4, CACNB2, COX6C, UQCR10, COX6B2, TNNT2, TNNC1, SLC9A1, UQCR11, UQCRB, UQCRHL, UQCRC1, CACNA1F, UQCRFS1, UQCRC2, COX6A1",0.0947439512515487,0,FALSE
+"transcriptomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.37321,1.08,0.34,3535,0.763,"CDH3, NECTIN1, CDH1, CLDN8, ITGB2, CLDN9, CLDN7, CLDN4, F11R, ITGB8, CDH5, SDC1, ICOSLG, SDC4, CLDN18, ICAM3, CD6, GLG1, CLDN11, CD40, SELL, PTPRF, CLDN23, CD276, CLDN3",0.468521082957745,0.11747546204512,FALSE
+"transcriptomics","Log2FC","KEGG_CELL_CYCLE",-0.36349,-1.24,0.163,15880,0.465,"ORC1, MCM4, PTTG2, CCNA2, ORC6, SMAD4, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, MCM3, ANAPC10, CDK6, CDC20, CDK1, SMC1A, CCNH, CCNB3, CDKN2C, CDC25A, TGFB1, ORC4, CCNB1, MCM6, PRKDC, TTK, CDC14A, CDKN2B, E2F2, BUB3, ORC2, CDC7, PTTG1, YWHAQ, HDAC2, SMC3, E2F5, ORC3, CDKN2A, E2F3, SMAD2, ANAPC13",0.787812395596042,0.332547047110046,FALSE
+"transcriptomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.31904,0.923,0.581,4742,0.952,"CCR3, PRKCD, CCL22, STAT2, GRK7, VAV1, PIK3R2, FOXO3, GRK2, CX3CL1, RAC2, VAV3, CCL17, JAK3, CXCL10, IKBKB, MAPK3, CCL28, CCR2, ARRB1, VAV2, CCR7, ADCY5, PIK3CA, ADCY4, CXCL11, CXCL16, CCL5, PTK2B, STAT5B, RAP1A, CXCL9, CXCR2, STAT3, BRAF, ADCY6, RELA, TIAM1, PXN, GNB2, TIAM2, CCL26, CCL19, CXCL3, PRKCZ, CXCR6, WASL, LYN, PIK3R3, STAT1, CCR1",0.235823867609669,0.0213630516155257,FALSE
+"transcriptomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.24297,0.703,0.912,6797,0.992,"CBLC, BCR, PIK3R2, IKBKB, MAPK3, PIK3CA, STAT5B, E2F1, CBLB, BRAF, CDKN1B, RELA, MECOM, RUNX1, BAD, PIK3R3, TGFB3, CRKL, STAT5A, TGFBR2, MAPK1, PIK3R5, PIK3CB, NFKBIA, CDKN1A, BCL2L1, GRB2, CTBP1, CCND1",0.0400051616715838,0.00348832784582135,FALSE
+"transcriptomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.41491,1.2,0.185,4027,0.673,"BHLHE41, NR1D1, CSNK1E, BHLHE40, PER3",0.732828271596986,0.171984935776023,FALSE
+"transcriptomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29489,0.843,0.711,7287,1,"PC, IDH2, ACO2, IDH3B, SDHD, OGDHL, MDH1, MDH2, OGDH, IDH3G, IDH1, SUCLG2, SDHA",0.148130399270234,0,FALSE
+"transcriptomics","Log2FC","KEGG_COLORECTAL_CANCER",-0.17873,-0.649,0.991,14592,1,"KRAS, RAF1, LEF1, CASP9, BIRC5, AKT2, MAPK9, BCL2, MSH6, CASP3, MSH3, RHOA, APPL1, APC2, AKT3, SMAD4, PIK3R1, PIK3CG, MSH2, APC, TGFB1, TCF7, MAPK8, AXIN2, SMAD2",0.00392634551472468,0,FALSE
+"transcriptomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.26321,0.77,0.815,6969,1,"BDKRB2, F3, BDKRB1, VWF, FGA, FGG, CFB, PROC, C3, PLAU, CD59, SERPINA5, C2, PLAT, SERPINA1, C9, C1R, CFI, F8, CD55, C4A, SERPINF2, F12, FGB",0.0888423912600234,0,FALSE
+"transcriptomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.22246,-0.76,0.82,15262,1,"BHMT, ADI1, MTR, CDO1, GOT2, SRM, LDHB, MAT2A, AMD1, SMS, MTAP, TRDMT1",0.0861861476162833,0,FALSE
+"transcriptomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33412,0.966,0.488,5572,0.865,"CCR3, IFNL3, IFNL1, CSF1R, CCL22, TNFSF13, IFNL2, IL1RAP, CRLF2, TNFRSF21, PDGFA, IL9R, BMP7, CX3CL1, TNFRSF18, CCL17, IL4R, VEGFB, CXCL10, LTBR, CCL28, CCR2, IFNLR1, EPOR, IFNB1, PDGFB, BMP2, CCR7, FLT3LG, MET, CXCL11, CXCL16, CCL5, TNFRSF25, EGFR, CTF1, ACVR1B, IL18, CD40, IL12B, CXCL9, TNFSF10, CXCR2, TNFRSF14, CLCF1, IL7R, EPO, CCL26, IL20RB, IL6R, IL6, NGFR, CCL19, CXCL3, IL20RA, TNFSF18, CXCR6, VEGFA, CSF2, TNFRSF12A, IL15RA, CCR1, LTB, IL12A, IL1R2, PRLR, TGFB3, CSF1, GH2, OSMR, INHBB, IL1A, VEGFC, EDAR, IFNGR1, TGFBR2, CXCL6, IL17RA, CSF2RB",0.311580177997289,0.0629838925351858,FALSE
+"transcriptomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.36654,1.06,0.328,3908,0.767,"CASP1, MAVS, RIPK3, IRF3, CXCL10, IKBKB, IFNB1, CCL5, DDX58, IL18, PYCARD, RELA, IKBKE, IL6",0.484126156288321,0.115204636051019,FALSE
+"transcriptomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.30112,0.866,0.689,4386,0.977,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ADCY5, ADCY4, ITGA3, CACNB2, DAG1, ITGA2B, ADCY6, TNNT2, TNNC1, GNAS, ITGA2",0.161780778092374,0.0101054362812269,FALSE
+"transcriptomics","Log2FC","KEGG_DNA_REPLICATION",-0.44719,-1.71,0.0108,15778,0.18,"DNA2, RFC2, MCM4, RFC5, MCM3, RNASEH1, PRIM1, MCM6, RNASEH2B, PRIM2, POLE3, RFC1, RPA2, POLA1",1.96657624451305,0.744727494896694,TRUE
+"transcriptomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.4409,1.28,0.127,5751,0.78,"ETV7, ETS2, MAPK3, ETV6, EGFR, NOTCH3, PIWIL2, NOTCH1, MAPK1, SPIRE1, SPIRE2",0.896196279044043,0.10790539730952,FALSE
+"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47037,1.35,0.0766,3662,0.771,"ADH7, ALDH3B2, GSTK1, CYP2E1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, FMO4, MGST2, CYP2D6, UGT2B17, MGST3",1.1157712303674,0.112945621949043,FALSE
+"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.40437,1.17,0.239,3623,0.723,"XDH, TYMP, NAT1, UCKL1, CES2, UPP1, TK1, CDA, UGT2B17, TPMT, GUSB, ITPA",0.621602099051862,0.140861702705469,FALSE
+"transcriptomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.39479,1.14,0.246,4629,0.728,"CHAD, LAMA3, ITGB6, LAMB3, ITGB8, SDC1, SDC4, CD47, TNC, LAMC2, GP6, ITGB4, CD44, AGRN, THBS3, VWF, ITGA3, DAG1, THBS1, ITGA2B, COL1A1, LAMA5, LAMB1, ITGA2, COL5A1, HSPG2",0.609064892896621,0.137868620686963,FALSE
+"transcriptomics","Log2FC","KEGG_ENDOCYTOSIS",0.41396,1.21,0.193,5701,0.676,"EPN3, CHMP4B, CBLC, PSD4, CSF1R, ITCH, TRAF6, RAB11FIP4, CHMP2B, GRK7, FGFR2, RAB22A, PLD1, ARFGAP1, CHMP2A, GRK2, RAB5B, ARAP1, ERBB3, TFRC, ACAP1, EHD2, PLD2, SMURF1, VPS37C, ARRB1, CHMP5, PRKCI, CHMP3, RAB11FIP1, MET, MVB12A, SH3GLB2, IGF1R, CHMP6, VPS28, ARAP2, PARD6B, EGFR, EPN1, ARFGAP3, VPS37B, FGFR3, LDLRAP1, CXCR2, ARFGAP2, CBLB, EPS15, AP2M1, ADRB2, SRC, HSPA1B, CHMP4C, RAB11FIP5, AGAP1, ACAP2, PRKCZ, AP2A1, NEDD4L, ARAP3, PIP5K1C, STAMBP, CHMP1B, LDLR, ASAP2, HSPA2, IQSEC1, DNM2, RAB11B, RAB31, ARF6, RAB5C, VPS25, STAM2",0.714442690992226,0.170053304058364,FALSE
+"transcriptomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.26466,0.768,0.846,3392,1,"CDH1, ERBB2, PIK3R2, FOXO3, MAPK3, PIK3CA, EGFR, BRAF, TCF7L1",0.0726296369609765,0,FALSE
+"transcriptomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.38362,1.1,0.294,6354,0.738,"MAPK13, PLCG2, F11R, ATP6V1C2, ATP6V0D2, ATP6V1B1, ATP6V1F, IKBKB, MET, CCL5, EGFR, ATP6AP1, CXCR2, PLCG1, RELA, SRC, MAPK11, NOD1, ADAM10, TCIRG1, LYN, ATP6V1G1, ATP6V0A4, RAC1, PAK1, MAPK10, ATP6V1C1, NFKBIA, TJP1, ATP6V1E1, IGSF5",0.531652669587843,0.131943638176958,FALSE
+"transcriptomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.39525,1.16,0.214,5894,0.724,"GAB1, PAK6, CBLC, ERBB2, PIK3R2, PLCG2, ERBB3, CAMK2G, MAPK3, RPS6KB2, PIK3CA, NCK2, EGFR, STAT5B, BTC, CBLB, BRAF, PLCG1, CDKN1B, SRC, TGFA, PAK2, AREG, BAD, PIK3R3, NCK1, CRKL, STAT5A, PAK1, PAK4, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB",0.669586226650809,0.140261433802853,FALSE
+"transcriptomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.38786,1.13,0.257,3971,0.705,"PLA2G12A, PLD1, PLA2G6, PLA2G4B, PLD2, LPCAT2, PLA2G10, PLA2G4E, PLPP3, LPCAT4, PLA2G2C",0.590066876668705,0.151810883008601,FALSE
+"transcriptomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38078,1.1,0.304,3627,0.738,"ADH7, ACAA1, CPT1B, GCDH, CYP4A22, ACSL1, CPT2, CPT1C, ACADS, EHHADH, ACOX1, ACSL3",0.517126416391246,0.131943638176958,FALSE
+"transcriptomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.33886,0.979,0.494,2596,0.867,"PRKCD, PLA2G12A, VAV1, MAPK13, PIK3R2, PLCG2, RAC2, VAV3, PLA2G6, PLA2G4B, MAPK3, VAV2, PIK3CA, PLA2G10, PLA2G4E",0.306273051076353,0.0619809025237897,FALSE
+"transcriptomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.40295,1.16,0.224,5894,0.724,"PRKCD, VAV1, PLD1, PIK3R2, PLCG2, RAC2, VAV3, LIMK2, PLA2G6, PLA2G4B, PLA2G4F, PLD2, MAPK3, RPS6KB2, VAV2, MARCKS, GSN, PIK3CA, PLA2G4E, PLCG1, PLPP3, SPHK2, WASL, LYN, PIK3R3, PIP5K1C, SPHK1, LIMK1, CRKL, SCIN, ASAP2, MYO10, DNM2, RAC1, PAK1, ARF6, MAPK1, PIK3R5, PIK3CB",0.649751981665837,0.140261433802853,FALSE
+"transcriptomics","Log2FC","KEGG_FOCAL_ADHESION",0.30588,0.889,0.64,6359,0.957,"PAK6, CHAD, ERBB2, LAMA3, VAV1, ITGB6, PDGFA, PIK3R2, LAMB3, ITGB8, RAC2, VAV3, VEGFB, TNC, LAMC2, ITGB4, MAPK3, PPP1CA, VAV2, PDGFB, PIK3CA, PPP1CB, MET, IGF1R, THBS3, VWF, PDGFD, ITGA3, EGFR, RAP1A, THBS1, ITGA2B, BRAF, CAV2, PXN, COL1A1, SRC, CAV1, MYL9, ARHGAP35, PAK2, LAMA5, BAD, PGF, LAMB1, ITGA2, COL5A1, VEGFA, RASGRF1, PIK3R3, PIP5K1C, CRKL, MYL7, ARHGAP5, VEGFC, RAC1, PAK1, BCAR1, PAK4, MAPK1, MAPK10, PIK3R5, PIK3CB, PTEN, COL1A2, ITGA5, TLN2, GSK3B, COL6A1, DIAPH1, ITGA4, CAPN2",0.193820026016113,0.0190880622231565,FALSE
+"transcriptomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.42522,1.23,0.169,5764,0.725,"ALPP, QDPR, SPR, FPGS",0.772113295386326,0.139661993429006,FALSE
+"transcriptomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5816,1.69,0.0111,3752,0.342,"ALDOC, PFKFB2, HK2, MPI, GMPPA, FBP1, GMPPB, PFKL, FBP2, MTMR1, FPGT, HK1, PFKFB4, ALDOA",1.95467702121334,0.465973893943865,FALSE
+"transcriptomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.52612,1.52,0.0308,3636,0.462,"HK2, GCK, GAA, PGM1, PFKL, B4GALT1, GALT, GANC, HK1, B4GALT2, GLB1, GALE",1.51144928349956,0.335358024443874,FALSE
+"transcriptomics","Log2FC","KEGG_GAP_JUNCTION",-0.17017,-0.601,1,15556,1,"ADRB1, TUBB3, ITPR2, MAP2K5, ADCY7, PRKX, TUBA1B, TUBB, GNAI1, ITPR1, TUBAL3, PRKACB, CDK1, PLCB4, PDGFRA, TUBA1A, NRAS, TUBB4A, TUBB2B, TUBB2A",0,0,FALSE
+"transcriptomics","Log2FC","KEGG_GLIOMA",0.26293,0.766,0.846,3686,0.994,"PDGFA, PIK3R2, PLCG2, CALML3, CAMK2G, MAPK3, PDGFB, PIK3CA, IGF1R, EGFR, E2F1, BRAF, PLCG1, TGFA",0.0726296369609765,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.33643,0.973,0.488,4600,0.865,"GSTK1, GGT7, GSTT2, GSTO2, GSS, IDH2, GSTZ1, GSTA3, OPLAH, MGST2, GGT6, GPX1, MGST3, ANPEP, G6PD, GPX3",0.311580177997289,0.0629838925351858,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.17981,0.518,0.998,5968,0.997,"DGKA, LIPG, DGAT1, MGLL, TKFC, PLPP3, CEL, DGKH, AGPAT2, PNPLA3, DGKI, AWAT2, MBOAT1, DGKE",0.000869458712628891,0.00130484168834428,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.36747,1.06,0.367,5053,0.767,"PISD, CDS1, PLA2G12A, CHKB, DGKA, PLD1, PLA2G6, PLA2G4B, PLD2, PCYT2, CHKA, LPCAT2, ETNK2, CDS2, PLA2G10, PLA2G4E, PLPP3, MBOAT7, LPCAT4, PLA2G2C, DGKH, AGPAT2, PGS1, LPCAT3, LYPLA2, ACHE, PCYT1A, DGKI",0.435333935747911,0.115204636051019,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31093,0.9,0.625,6983,0.966,"AGXT, GCAT, AOC2, GATM, SARDH, SHMT1, MAOA, AMT, GAMT, CTH, SDS, GNMT, AOC3, ALAS2, SRR",0.204119982655925,0.0150228735845067,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.4334,1.26,0.141,1880,0.765,"LDHC, ADH7, ACSS2, ALDH3B2, ALDOC, HK2, ALDH1A3, GCK, ALDH3B1, FBP1, PGM1, GALM, PFKL",0.85078088734462,0.116338564846382,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.43624,1.26,0.152,4160,0.765,"B4GALT7, CHPF, CHST12, XYLT2, CHST14, XYLT1, CHPF2, CHST11, CHST15",0.818156412055227,0.116338564846382,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.45434,1.33,0.0999,3529,0.806,"B4GALT7, EXT1, HS3ST1, XYLT2, HS6ST1, NDST1, HS6ST2, XYLT1",1.00043451177402,0.0936649581949093,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66703,1.93,0.00221,3600,0.281,"B3GNT7, CHST6, B4GALT4, B4GALT1, B3GNT2, CHST4, ST3GAL1, B4GALT2",2.65560772631489,0.55129368009492,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.5591,1.62,0.0148,4196,0.343,"HGSNAT, NAGLU, HPSE, HYAL4, IDS, GALNS, HYAL2, GUSB, GLB1, HEXB",1.82973828460504,0.464705879957229,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.42593,1.24,0.16,6306,0.758,"ST6GALNAC5, B3GALT4, SLC33A1, ST3GAL1, GLB1, HEXB, ST6GALNAC6, ST6GALNAC4, HEXA, ST8SIA1",0.795880017344075,0.120330794367946,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.58271,1.68,0.0135,4276,0.305,"FUT2, FUT1, NAGA, B3GALNT1, ST3GAL1, GBGT1, A4GALT, HEXB, B3GALT5",1.86966623150499,0.515700160653214,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.59777,1.73,0.00448,3600,0.327,"B3GNT3, ABO, FUT3, FUT2, B4GALT4, B3GNT5, B3GNT4, B4GALT1, FUT1, B3GNT2, ST3GAL4, B4GALT2",2.34872198600186,0.485452247339714,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50004,1.45,0.0565,3611,0.59,"PIGT, PIGU, GPAA1, PIGZ, PIGV, PIGQ, PIGL, PIGX, PIGS",1.24795155218056,0.229147988357856,FALSE
+"transcriptomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.50461,-1.71,0.0427,16224,0.18,"HYI, MTHFD2L, MTHFD2, ACO1, CS, MTHFD1L, HAO2",1.36957212497498,0.744727494896694,TRUE
+"transcriptomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34964,1.01,0.418,2596,0.814,"PRKCD, PLA2G12A, MAPK13, PLD1, CACNA1D, PLA2G6, CALML3, PLA2G4B, MAP3K4, PLD2, CAMK2G, MAPK3, MAP3K1, ADCY5, CGA, ADCY4, MMP14, PTK2B, PLA2G10, EGFR, PLA2G4E",0.378823718224965,0.0893755951107988,FALSE
+"transcriptomics","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.20626,-0.725,0.907,3907,1,"IL6, IL1A, KLRC1, KIR2DL1, IL1B, KIR2DL3, KIR3DL2, CD86, FAS, CD80, IFNG, CD28, TNF, KLRD1, GZMB, FASLG, IL2, PRF1",0.0423927129399047,0,FALSE
+"transcriptomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36379,1.05,0.356,2621,0.766,"WNT3A, WNT9A, WNT7B, BMP7, WNT7A, WNT4, BMP2, CSNK1E, WNT10A, CSNK1A1, GLI3",0.448550002027125,0.115771230367396,FALSE
+"transcriptomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.38485,1.1,0.309,6109,0.738,"CSF1R, IL9R, IL4R, TFRC, EPOR, FLT3LG, CD44, ITGA3, CD9, ITGA2B, CD19, IL7R, EPO, IL6R, IL6, ANPEP, CD59, ITGA2, CSF2, CD4, IL1R2, CSF1, IL1A, IL1R1, CD1D, CD55, ITGA5",0.510041520575165,0.131943638176958,FALSE
+"transcriptomics","Log2FC","KEGG_HISTIDINE_METABOLISM",0.35152,1.02,0.42,1584,0.793,"ALDH3B2, HEMK1, HAL, ALDH1A3, ALDH3B1",0.3767507096021,0.100726812682396,FALSE
+"transcriptomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.23381,0.681,0.927,764,0.998,"POLD4, SEM1",0.0329202658555029,0.000869458712628891,FALSE
+"transcriptomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.17121,-0.59,0.979,16664,0.989,"ITPR1, NDUFS4, BBC3, AP2S1, SOD1, COX6B1, COX7A2, DCTN4, AP2A2, PLCB4, ATP5F1C, NDUFA9, VDAC2, POLR2E, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, HDAC2, HIP1, TBPL1, TBP, UCP1, ATP5F1A, POLR2D, BDNF, NDUFS5, TFAM, GRIN2B",0.00921730819686218,0.0048037084028206,FALSE
+"transcriptomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30969,0.896,0.624,4437,0.967,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ITGA3, CACNB2, DAG1, ITGA2B, PRKAA1, ACE, TNNT2, IL6, TNNC1, ITGA2, PRKAG2",0.204815410317576,0.0145735259169983,FALSE
+"transcriptomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30094,0.881,0.667,6116,0.959,"PLCG2, INPP4B, PLCD1, INPP4A, ALDH6A1, PIK3CA, PIP4K2C, PLCG1, PIK3C2G, PIK3C2B, INPP5K, IMPA2, PIP5K1C, INPPL1, INPP5J, ISYNA1, PIK3CB, PTEN, PLCB3, IPMK",0.175874166083451,0.0181813928293364,FALSE
+"transcriptomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.32542,0.945,0.526,6911,0.907,"CBLC, PPP1R3D, HK2, PTPN1, PIK3R2, GYS1, CALML3, SOCS1, MKNK1, GCK, IKBKB, MAPK3, RPS6KB2, FBP1, INSR, PPP1CA, SH2B2, PIK3CA, PPP1CB, PRKCI, TSC1, FBP2, IRS2, PTPRF, CBLB, BRAF, PRKAA1, PHKG1, HK1, FOXO1, PRKCZ, BAD, PRKAG2, INPP5K, EXOC7, PIK3R3, FASN, PYGL, CALML6, CRKL, PRKAB2, PRKACA, RHEB, PPP1R3B, MAPK1, FLOT2, MAPK10, PIK3R5, IRS1, PIK3CB, PRKAR1B, GSK3B, PHKG2, TRIP10, GRB2, INPP5D, PYGB, PRKAG1, TSC2, RPTOR",0.279014255846261,0.0423927129399047,FALSE
+"transcriptomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.3125,0.906,0.613,3908,0.97,"TNFSF13, ICOSLG, LTBR, CCL28, CD40, PIGR, IL6",0.212539525481585,0.0132282657337552,FALSE
+"transcriptomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.33678,0.978,0.487,5894,0.86,"IFNL3, IFNL1, CBLC, STAT2, IFNL2, CRLF2, PIK3R2, IL9R, IRF9, JAK3, IL4R, SOCS1, CISH, IFNLR1, EPOR, PTPN6, IFNB1, PIK3CA, TYK2, EP300, STAT6, CTF1, STAT5B, IL12B, CBLB, STAT3, CLCF1, IL7R, EPO, IL20RB, IL6R, IL6, PIAS3, IL20RA, PIM1, CSF2, PIK3R3, SPRY1, IL15RA, STAT1, IL12A, PRLR, GH2, STAT5A, OSMR, IFNGR1, JAK1, CSF2RB, STAM2, PIK3R5, PIK3CB",0.312471038785366,0.0655015487564323,FALSE
+"transcriptomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.42556,1.23,0.169,6358,0.725,"TRAF6, ITGB2, NCF4, MAPK13, MAPK3, PTPN6, MYD88, IL12B, TAB1, RELA, MAPK11, C3, TLR2, IRAK4, STAT1, IL12A, TGFB3, IL1A, IFNGR1, JAK1, TAB2, MAPK1, NFKBIA, FOS, ITGA4",0.772113295386326,0.139661993429006,FALSE
+"transcriptomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.41873,1.21,0.197,3793,0.676,"CTNND1, CLDN8, ITGB2, MMP9, CLDN9, VAV1, NCF4, CLDN7, MAPK13, PIK3R2, PLCG2, CLDN4, F11R, CDH5, RAC2, VAV3, VAV2, CLDN18, PIK3CA, RASSF5, PTK2B, RAP1A, CLDN11, RAPGEF3, PLCG1, SIPA1, PXN, CLDN23, CLDN3, MYL9, MAPK11, ARHGAP35",0.705533773838407,0.170053304058364,FALSE
+"transcriptomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.42081,-1.51,0.0531,15341,0.332,"ALDH3A2, HADHA, YOD1, ALDH1B1, ALDH7A1, ALDH9A1",1.27490547891853,0.478861916295964,FALSE
+"transcriptomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.40266,1.17,0.225,2596,0.723,"PLA2G12A, CYP2E1, PLA2G6, PLA2G4B, CYP2J2, PLA2G10, PLA2G4E",0.647817481888638,0.140861702705469,FALSE
+"transcriptomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.24312,0.697,0.91,6599,0.99,"PLA2G12A, GNAO1, PLA2G6, PLA2G4B, MAPK3, IGF1R, RYR1, PLA2G10, PLA2G4E, BRAF, PLA2G2C, GNAS, GNAQ, LYN, ITPR3, MAPK1, PLCB3, PPP2R1A, GUCY1A1, NOS1, PLA2G2F, GUCY1B1, GNA12",0.0409586076789064,0.00436480540245009,FALSE
+"transcriptomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23447,0.677,0.924,5774,0.994,"GRIN1, CALML3, CAMK2G, MAPK3, PPP1CA, PPP1CB, EP300, RAP1A, RAPGEF3, GRIN2A, BRAF, GRIN2D, CHP1, PPP3CA, GNAQ, RPS6KA2, CALML6, ITPR3, PRKACA, MAPK1, RPS6KA1",0.0343280287798933,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_LYSINE_DEGRADATION",0.22598,0.655,0.957,2472,0.983,"BBOX1, KMT5B, KMT5C, GCDH, AASDH, EHHADH",0.0190880622231565,0.00744648216786438,FALSE
+"transcriptomics","Log2FC","KEGG_LYSOSOME",0.52683,1.52,0.0362,5277,0.462,"CTSH, GM2A, CTSA, CTSV, HGSNAT, SLC11A1, NAGLU, GGA2, CTSD, ARSA, ATP6V0D2, LIPA, DNASE2, ABCB9, SUMF1, GAA, MANBA, NPC1, NAGA, ACP5, PSAP, IDS, GNPTG, NPC2, AP1M2, GALNS, CTSS, LAPTM4A, NAPSA, AP1B1, AP3M2, GGA1, LGMN, NEU1, TPP1, ATP6AP1, PSAPL1, ASAH1, LAMP3, CD68, CTSB, LAMP1, CLN5, GUSB, GLB1, GGA3, AP3S2, LAMP2, FUCA1, NAGPA, SCARB2, CTSE, HEXB, PPT1, AP1S1, TCIRG1, MAN2B1, CD63, SLC11A2, MFSD8, ABCA2, CTSZ, SORT1, AP1S3, ATP6V0A4, ENTPD4, GBA",1.44129142946683,0.335358024443874,FALSE
+"transcriptomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.26798,0.771,0.843,5856,1,"NTF4, PLA2G12A, TRAF6, FGF11, FGFR2, MAPK13, PDGFA, CACNA1D, RAC2, CACNG1, PLA2G6, PLA2G4B, MAP3K4, MKNK1, DUSP9, CACNB3, HSPB1, CACNG4, IKBKB, MAPK3, ARRB1, MAP4K1, MAP3K1, PDGFB, CACNA1I, FGF1, DUSP3, MAPK8IP2, MAX, NTRK2, PLA2G10, EGFR, CACNB2, PLA2G4E, MAP3K11, MAPKAPK3, RAP1A, JUND, ECSIT, MAP3K6, TAB1, LAMTOR3, FGFR3, MAP3K13, TAOK3, BRAF, DUSP10, RELA, STK3, DUSP14, CHP1, HSPA1B, MAPK11, PPP3CA, PAK2, PLA2G2C, MECOM, MAP3K8, GADD45B, RASGRF1, FGF12, MAP4K2, MAP3K5, RPS6KA2, IL1R2, RASA1, RPS6KA4, MAPKAPK2, NF1, STK4, TGFB3, CRKL, PPM1A, HSPA2, NGF, PRKACA, IL1A, RAC1, PAK1, MAP4K3, TGFBR2, RRAS, TAB2, MAPK1, DUSP8, MAP2K7, NLK, GADD45A, RPS6KA1, MAPK10, MAPK8IP3, CACNA1F",0.0741724253752577,0,FALSE
+"transcriptomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26478,0.766,0.83,1432,0.994,"HES1, GCK",0.0809219076239261,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_MELANOGENESIS",0.36219,1.05,0.373,6175,0.766,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, GNAO1, CALML3, WNT4, DVL3, CAMK2G, MAPK3, ADCY5, WNT10A, ADCY4, EP300, ADCY6, TCF7L1, FZD4, CREB3L4, DVL2, WNT11, GNAS, GNAQ, CALML6, CREB3L3, MITF, PRKACA, ASIP, CREB3L2, MAPK1, EDN1, CREB3L1, WNT5A, PLCB3, FZD6, GSK3B",0.428291168191312,0.115771230367396,FALSE
+"transcriptomics","Log2FC","KEGG_MELANOMA",-0.26432,-0.868,0.592,16564,0.965,"PIK3R1, PIK3CG, FGF20, CDK6, FGF21, FGF2, PDGFRA, E2F2, NRAS, IGF1, FGF9, FGF4, CDKN2A, FGF5, FGFR1, E2F3, FGF19, FGF3",0.22767829327708,0.0154726866562074,FALSE
+"transcriptomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.45636,1.31,0.122,3662,0.806,"ADH7, ALDH3B2, GSTK1, DHDH, CYP2E1, CYP1B1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, MGST2, UGT2B17, MGST3",0.913640169325252,0.0936649581949093,FALSE
+"transcriptomics","Log2FC","KEGG_MISMATCH_REPAIR",-0.32549,-1.14,0.257,15319,0.598,"MSH6, RFC3, MSH3, RFC2, RFC5, EXO1, MSH2, RFC1, RPA2",0.590066876668705,0.223298816011589,FALSE
+"transcriptomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35512,1.04,0.369,6050,0.764,"PIK3R2, VEGFB, MAPK3, RPS6KB2, PIK3CA, TSC1, CAB39, RICTOR, BRAF, PRKAA1, PGF, VEGFA, PIK3R3, HIF1A, RPS6KA2, DDIT4, VEGFC, RHEB, MAPK1, RPS6KA1, PIK3R5, PIK3CB, ULK1",0.43297363384094,0.11690664142431,FALSE
+"transcriptomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.2602,0.75,0.849,6624,0.987,"ITGB2, VAV1, PIK3R2, PLCG2, RAC2, VAV3, RAET1L, MAPK3, PTPN6, VAV2, IFNB1, PIK3CA, SH3BP2, PTK2B, TNFSF10, BRAF, PLCG1, CHP1, PPP3CA, LCK, CSF2, PIK3R3, ULBP2, RAC1, IFNGR1, PAK1, BID, MAPK1, NFATC1, PIK3R5, PIK3CB, SYK, NFATC4, HCST, GRB2, CHP2",0.0710923097560473,0.00568284733036327,FALSE
+"transcriptomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.21335,0.619,0.971,5100,0.991,"DRD5, P2RY2, VIPR2, PTAFR, BDKRB2, P2RY6, P2RX4, LPAR2, VIPR1, S1PR4, THRB, GRIN1, NPBWR1, ADORA1, ADORA2B, ADORA2A, GIPR, S1PR2, GALR3, CGA, BDKRB1, GHSR, GABRP, F2RL3, GRIN2A, OPRL1, CHRNB4, MLNR, S1PR5, ADRB2, GRIN2D, P2RX6, EDNRA, F2RL1, MC3R, P2RX2, LTB4R2, HTR7, CHRNB1, ADRA2A, GRIN3B, GRM4, LTB4R, PRLR, ADRA2B, GH2",0.0127807700919951,0.00392634551472468,FALSE
+"transcriptomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.33316,0.966,0.512,5975,0.865,"GAB1, NTF4, PRKCD, TRAF6, MAPK13, PIK3R2, PLCG2, FOXO3, CALML3, ARHGDIB, IKBKB, CAMK2G, MAPK3, MAP3K1, SH2B2, PIK3CA, NTRK2, RAP1A, IRS2, TP73, BRAF, PLCG1, YWHAB, RELA, MAPK11, NGFR, IRAK4, BAD, YWHAZ, MAP3K5, PIK3R3, YWHAH, RPS6KA2, SORT1, CALML6, RPS6KA4, MAPKAPK2, CRKL, NGF, RAC1, BAX, MAPK1, MAP2K7, RPS6KA1, MAPK10, PIK3R5, IRS1, PIK3CB, NFKBIA",0.290730039024169,0.0629838925351858,FALSE
+"transcriptomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.264,0.761,0.818,4274,0.994,"QPRT, NMRK1, NADSYN1, NADK, NT5C1B",0.087246696328677,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_NITROGEN_METABOLISM",0.31831,0.925,0.553,2116,0.957,"GLUL, HAL, GLS2, CA9",0.257274868695302,0.0190880622231565,FALSE
+"transcriptomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34339,0.985,0.463,4477,0.859,"CASP1, TRAF6, MAPK13, TAB3, IKBKB, MAPK3, TRIP6, CCL5, IL18, PYCARD, TAB1, RELA, CARD6, MAPK11, IL6, NOD1, NOD2, PSTPIP1, NLRP1",0.334419008982047,0.0660068361687577,FALSE
+"transcriptomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.55072,-2.02,0,17605,0.331,"RAD50, PRKDC, NHEJ1, XRCC5",Inf,0.480172006224281,FALSE
+"transcriptomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.34338,0.992,0.454,3686,0.848,"ERBB2, RXRA, PIK3R2, PLCG2, FOXO3, MAPK3, PIK3CA, RASSF5, RXRB, EGFR, E2F1, BRAF, PLCG1, TGFA",0.342944147142896,0.0716041477432862,FALSE
+"transcriptomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.39588,1.15,0.237,5482,0.725,"DTX4, HES1, DVL3, DTX3L, JAG1, DTX2, RFNG, EP300, DLL1, LFNG, NOTCH3, APH1A, MFNG, DVL2, JAG2, NUMB, NOTCH1, KAT2A, HES5",0.625251653989896,0.139661993429006,FALSE
+"transcriptomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.30853,-1.03,0.337,15978,0.693,"RFC2, XPC, RFC5, GTF2H1, XPA, GTF2H3, ERCC3, CUL4A, ERCC8, CCNH, ERCC1, POLE3, RFC1, RPA2, GTF2H2",0.472370099128661,0.159266765388193,FALSE
+"transcriptomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39086,1.13,0.248,3600,0.705,"MAN1B1, RPN2, ALG12, ALG3, DPM1, MOGS, MGAT4A, MGAT1, B4GALT1, MGAT5B, STT3A, ALG2, B4GALT2",0.605548319173784,0.151810883008601,FALSE
+"transcriptomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.24959,0.721,0.902,7709,1,"OR4C6, OR10H2, OR2J3, OR11H4, OR8A1, OR2A12, OR2D3, GUCY2D, CALML3, OR8B8, CAMK2G, CLCA2, OR1G1, OR2A7, OR13H1, OR1I1, OR13D1, CNGB1, OR1F1, OR8G5, OR8G1, OR10A3, OR1M1, OR6Q1, OR1K1, OR5P2, OR10H1, OR10A4, OR4D2, OR2A2, CNGA4, OR52B4, CALML6, OR2D2, OR2B2, OR1J1, OR6B1, PRKACA, OR2A14, GUCA1B, OR52K1, OR9A2, OR10A6, OR4L1, OR10AD1, OR2S2, OR10S1, OR10A2, OR2A5, OR10K2, OR10A5, OR8S1, OR4X2, OR5P3, ADCY3, OR6C70, OR8D2, OR8B4, OR2L2, CAMK2D, OR10G3, PRKG2, OR4K1, PRKACG, GRK3, OR8D1, OR52I1, OR6A2",0.0447934624580583,0,FALSE
+"transcriptomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44426,-1.49,0.0698,14974,0.282,"DHFR, SHMT2, MTHFS, MTR, MTHFD2L, GART, MTHFD2, MTHFD1L, TYMS, ATIC",1.15614457737684,0.549750891680639,FALSE
+"transcriptomics","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.25168,-0.876,0.643,15742,0.981,"ITPR2, PPP2R5D, PPP3CC, ADCY7, PPP2R5C, PRKX, RPS6KA3, PTTG2, PPP2CB, PPP2R1B, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, ITPR1, ANAPC10, FBXO5, CDC20, PRKACB, PPP3R1, CDK1, SMC1A, CALM2, CCNB1, FBXO43, CPEB1, AR, PTTG1, YWHAQ, SGO1, SMC3, IGF1, PPP1CC, ANAPC13",0.191789027075778,0.0083309926200515,FALSE
+"transcriptomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",0.61199,1.76,0.00562,5940,0.349,"MANBA, NEU1, ENGASE, MAN2B2, MAN2C1, GLB1, FUCA1, HEXB, MAN2B1, GBA, HEXA, AGA",2.25026368443094,0.45717457304082,FALSE
+"transcriptomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",0.23049,0.668,0.939,6376,0.987,"NDUFV1, LHPP, ATP6V1C2, COX5B, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP5F1E, NDUFB7, NDUFS8, NDUFA3, NDUFV2, ATP6AP1, COX6C, UQCR10, COX6B2, SDHD, UQCR11, TCIRG1, NDUFB4, NDUFAB1, ATP6V1G1, UQCRB, ATP6V0A4, NDUFA6, UQCRHL, NDUFA5, UQCRC1, NDUFB5, COX15, ATP5MG, UQCRFS1, ATP6V1C1, UQCRC2, COX6A1, ATP6V1E1, NDUFA2, COX17, ATP5PD",0.0273344077338891,0.00568284733036327,FALSE
+"transcriptomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.49419,1.42,0.0645,4056,0.649,"GALNT12, GALNT3, GALNT7, GALNT6, B4GALT5, GCNT1, ST6GALNAC1, GCNT3, C1GALT1, GALNT15, ST3GAL1, GALNT11, GALNT9, B3GNT6",1.19044028536473,0.187755303199631,FALSE
+"transcriptomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.1914,0.56,0.989,5981,1,"TP53AIP1, CCNG2, CD82, SERPINB5, SFN, THBS1, TP73, ATR, PERP, SHISA5, EI24, GADD45B, ZMAT3, CCNE1, SIAH1, PIDD1, BID, IGFBP3, BAX, CHEK2, GADD45A, PTEN",0.0048037084028206,0,FALSE
+"transcriptomics","Log2FC","KEGG_PANCREATIC_CANCER",0.34675,1,0.44,5894,0.834,"ERBB2, PLD1, PIK3R2, RALB, RAC2, VEGFB, IKBKB, MAPK3, RALGDS, PIK3CA, EGFR, E2F1, RALBP1, STAT3, BRAF, RELA, TGFA, BAD, PGF, VEGFA, PIK3R3, STAT1, TGFB3, RALA, VEGFC, RAC1, JAK1, TGFBR2, MAPK1, MAPK10, PIK3R5, PIK3CB",0.356547323513813,0.0788339493622613,FALSE
+"transcriptomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.31788,0.92,0.571,8542,0.95,"PANK2, PPCS, ENPP1, COASY, UPB1, PPCDC, BCAT2, DPYD, VNN2",0.243363891754152,0.0222763947111523,FALSE
+"transcriptomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.18037,-0.604,1,17631,1,"UBE2J2, ATP5F1C, NDUFA9, VDAC2, LRRK2, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, UCHL1, ATP5F1A, SLC18A2, PARK7, NDUFS5",0,0,FALSE
+"transcriptomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.30571,-1.09,0.283,18248,0.576,"YWHAQ, TUBA1A, NCL, ROCK2, TUBB4A, ARHGEF2, TUBB2B, TUBB2A",0.54821356447571,0.239577516576788,FALSE
+"transcriptomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.2849,0.828,0.749,5981,0.999,"WNT3A, WNT9A, CBLC, CSF1R, WNT7B, CDH1, ERBB2, FZD10, LAMA3, TRAF6, FGF11, MMP9, RXRA, BCR, FGFR2, TRAF4, PLD1, PDGFA, PIK3R2, PLCG2, RALB, LAMB3, EGLN3, WNT7A, RAC2, WNT4, VEGFB, LAMC2, DVL3, IKBKB, MAPK3, RALGDS, PML, PDGFB, RARA, BMP2, FLT3LG, PIK3CA, JUP, RASSF5, WNT10A, FADD, RXRB, MET, IGF1R, FGF1, MAX, ITGA3, EP300, EGFR, GLI3, STAT5B, E2F1, DAPK1, RALBP1, FGFR3, ITGA2B, PPARG, CBLB, ARNT2, STAT3, BRAF, PLCG1, CDKN1B, RELA, TCF7L1, FZD4, TGFA, FOXO1, IL6, DVL2, MECOM, LAMA5, WNT11, RUNX1, BAD, PGF, PIAS3, LAMB1, EPAS1, ITGA2, VEGFA, FGF12, DAPK2, PIK3R3, HIF1A, STAT1, CCNA1, CCNE1, STK4, TGFB3, CRKL, PTCH1, RALA, MITF, SLC2A1, STAT5A, VEGFC, RAC1, JAK1, BID, TGFBR2, BAX, MAPK1, WNT5A, MAPK10, PIK3R5, TFG, PIK3CB, CEBPA, NFKBIA, PTEN",0.125518182300534,0.000434511774017692,FALSE
+"transcriptomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.47895,1.39,0.0906,4741,0.666,"DHDH, UGT2B17, GUSB, RPEL1, DCXR",1.04287180232319,0.176525770829699,FALSE
+"transcriptomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.43515,1.28,0.122,5085,0.78,"PGLS, ALDOC, FBP1, PGM1, PFKL, FBP2, ALDOA, H6PD, G6PD, RPEL1, RBKS, DERA, PGM2",0.913640169325252,0.10790539730952,FALSE
+"transcriptomics","Log2FC","KEGG_PEROXISOME",0.42548,1.23,0.159,5270,0.725,"CAT, ACOT8, GSTK1, PRDX5, PEX11A, XDH, PXMP4, ACAA1, MVK, AGXT, PEX11G, PEX2, HMGCL, EPHX2, PAOX, IDH2, ACSL1, EHHADH, PEX11B, CROT, ABCD1, ACOX1, ACSL3, PEX10, PEX13, PEX26, SCP2, PEX7, MLYCD, SLC25A17, ABCD4, PEX1, ACSL5, ACSL6",0.798602875679548,0.139661993429006,FALSE
+"transcriptomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.40531,1.18,0.192,5148,0.722,"ALDH3B2, ALDH1A3, ALDH3B1, AOC2, NAA80, IL4I1, TAT, MAOA, MIF",0.71669877129645,0.141462802430361,FALSE
+"transcriptomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.30436,0.881,0.653,6064,0.959,"CDS1, DGKA, PIK3R2, PLCG2, INPP4B, PLCD1, CALML3, INPP4A, PIK3CA, PIP4K2C, CDS2, PLCG1, PIK3C2G, PIK3C2B, DGKH, INPP5K, IMPA2, PIK3R3, PIP5K1C, CALML6, DGKI, ITPR3, INPPL1, INPP5J, PIK3R5, PIK3CB, DGKE, PTEN, PLCB3",0.185086818724926,0.0181813928293364,FALSE
+"transcriptomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.31034,0.902,0.621,4098,0.97,"ALAD, CP, HMOX2, FTH1, UGT2B17, MMAB, GUSB, HMBS",0.20690839982342,0.0132282657337552,FALSE
+"transcriptomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.41424,1.2,0.186,5270,0.673,"RXRA, ACAA1, CPT1B, PPARA, PLIN1, CYP4A22, FABP6, ACSL1, RXRB, CPT2, CPT1C, EHHADH, SLC27A6, PLTP, SLC27A1, PPARG, ACOX1, ACSL3, SCD5, SLC27A4, SCP2, OLR1, ACSL5, ACSL6",0.730487055782084,0.171984935776023,FALSE
+"transcriptomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.20209,-0.694,0.959,14148,1,"ACOX2, HSD17B4, CYP7A1, HSD3B7, AKR1C4, CYP39A1, BAAT",0.0181813928293364,0,FALSE
+"transcriptomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.5701,1.64,0.0145,4719,0.344,"RFXANK, BLNK, RAG1, JAK3, CD40, ADA, CD79A, RAG2, CD19, IL7R, CIITA, LCK, CD4",1.83863199776503,0.46344155742847,FALSE
+"transcriptomics","Log2FC","KEGG_PRION_DISEASES",0.24524,0.708,0.908,5622,1,"MAPK3, CCL5, IL6, NOTCH1, PRKACA, IL1A, C9, BAX, MAPK1, EGR1",0.0419141514789149,0,FALSE
+"transcriptomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28022,-0.912,0.589,15860,0.912,"ADCY7, PRKX, RPS6KA3, CCNA2, AKT3, MAD2L2, BUB1, CDC25C, CDC23, PIK3R1, GNAI1, PIK3CG, CCNB2, ANAPC10, PRKACB, CDK1, CCNB3, CDC25A, CCNB1, MAPK8, CPEB1, IGF1, HSP90AB1, HSP90AA1, ANAPC13, PDE3A, PDE3B",0.229884705212898,0.0400051616715838,FALSE
+"transcriptomics","Log2FC","KEGG_PROPANOATE_METABOLISM",0.35657,1.03,0.382,3581,0.774,"LDHC, ACSS2, ALDH6A1, ABAT, MCEE, EHHADH, PCCB, ACSS1",0.417936637088291,0.111259039317107,FALSE
+"transcriptomics","Log2FC","KEGG_PROSTATE_CANCER",0.26783,0.788,0.807,6422,1,"ERBB2, FGFR2, PDGFA, PIK3R2, IKBKB, MAPK3, PDGFB, PIK3CA, IGF1R, PDGFD, EP300, EGFR, E2F1, BRAF, CDKN1B, RELA, TCF7L1, CREB3L4, TGFA, FOXO1, BAD, PIK3R3, CCNE1, CREB3L3, CREB3L2, MAPK1, CREB5, CREB3L1, PIK3R5, PIK3CB, NFKBIA, PTEN, GSK3B, CDKN1A, CREB3",0.0931264652779296,0,FALSE
+"transcriptomics","Log2FC","KEGG_PROTEASOME",-0.31612,-1.09,0.314,15132,0.576,"PSMB5, PSMD4, PSMD6, PSMC5, PSMB4, PSMA6, PSMD7, PSMC1, PSMC6, PSMD1, PSMC4, PSMB7, PSMA4, PSMA1, PSMD8, PSMB1, POMP, PSMD14",0.503070351926785,0.239577516576788,FALSE
+"transcriptomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.31244,-1.1,0.327,16054,0.655,"SEC61A2, SEC11A, SRPRB, SRP72, SRP9, SRP19, SEC11C, SEC63",0.485452247339714,0.183758700008217,FALSE
+"transcriptomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.19349,0.559,0.988,8289,0.998,"GLS2, SLC9A3, SLC25A10, MDH1, SLC4A4, GLUD1, ATP1A2, AQP1, ATP1A1",0.00524305541237188,0.000869458712628891,FALSE
+"transcriptomics","Log2FC","KEGG_PURINE_METABOLISM",-0.30249,-1.09,0.273,15717,0.576,"PNPT1, PRPS1, RRM2, ADCY7, PFAS, POLR3B, ENTPD8, POLR2L, RRM2B, PAICS, ADSL, APRT, GART, NPR2, RRM1, PDE6B, PNP, PRIM1, NME1, PDE6C, POLR3G, PDE8A, POLR3A, AK5, NME7, PPAT, PDE11A, PRIM2, POLE3, POLR2E, POLR3C, PDE1A, ATIC, ENTPD1, PDE4B, PDE4D, POLR2D, POLR1E, PDE3A, PDE3B, POLA1, PDE10A, PDE7B, PDE8B",0.563837352959244,0.239577516576788,FALSE
+"transcriptomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.25943,-0.922,0.545,14988,0.92,"DHODH, POLE, NT5E, NME2, UPP2, CAD, POLR2C, POLR3K, PNPT1, RRM2, POLR3B, ENTPD8, POLR2L, RRM2B, AK3, TXNRD1, DTYMK, RRM1, PNP, PRIM1, NME1, TYMS, POLR3G, POLR3A, NME7, PRIM2, POLE3, POLR2E, POLR3C, ENTPD1, POLR2D, POLR1E, UCK2, POLA1, CTPS1",0.263603497723358,0.0362121726544447,FALSE
+"transcriptomics","Log2FC","KEGG_PYRUVATE_METABOLISM",0.22031,0.632,0.974,1378,0.991,"LDHC, ACSS2, PC",0.0114410431213845,0.00392634551472468,FALSE
+"transcriptomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.28027,0.811,0.781,5612,1,"PAK6, SSH3, BDKRB2, MYH14, BAIAP2, FGF11, ITGB2, VAV1, FGFR2, ITGB6, PDGFA, PIK3R2, ITGB8, RAC2, VAV3, LIMK2, FGD3, ITGB4, ARHGEF4, MAPK3, PPP1CA, VAV2, GSN, PDGFB, PFN4, PIK3CA, PPP1CB, PIP4K2C, BDKRB1, FGF1, SSH2, PDGFD, ITGA3, EGFR, FGFR3, ITGA2B, BRAF, TIAM1, PXN, MYL9, TIAM2, ARHGAP35, PAK2, SLC9A1, ITGA2, WASL, FGF12, PIK3R3, PIP5K1C, LIMK1, CRKL, ARHGEF7, SCIN, MYL7, RAC1, IQGAP1, PAK1, RRAS, BCAR1, ITGAX, PAK4, MAPK1",0.1073489661227,0,FALSE
+"transcriptomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.20206,-0.714,0.876,18035,1,"PIK3C3, PRKAA2, IFNA13",0.0574958938319193,0,FALSE
+"transcriptomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3643,1.05,0.374,5894,0.766,"GAB1, PAK6, PIK3R2, EGLN3, VEGFB, MAPK3, PDGFB, PIK3CA, MET, EP300, RAP1A, ARNT2, BRAF, TGFA, PAK2, PGF, EPAS1, VEGFA, PIK3R3, HIF1A, TGFB3, CRKL, FLCN, SLC2A1, VEGFC, RAC1, PAK1, PAK4, MAPK1, PIK3R5, PIK3CB",0.42712839779952,0.115771230367396,FALSE
+"transcriptomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.39819,1.15,0.23,4025,0.725,"CTSA, ACE2, ACE, ANPEP",0.638272163982407,0.139661993429006,FALSE
+"transcriptomics","Log2FC","KEGG_RETINOL_METABOLISM",0.43832,1.25,0.149,5807,0.749,"ADH7, RDH16, CYP26B1, DHRS9, DHRS3, DGAT1, CYP4A22, CYP26A1, UGT2B17, CYP1A1, RDH10, RDH11, LRAT, CYP26C1, CYP2C9, CYP2A7, ALDH1A2, AWAT2, CYP2C8",0.826813731587726,0.125518182300534,FALSE
+"transcriptomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.28656,0.831,0.75,3165,1,"ACP6, ACP5, MTMR1",0.1249387366083,0,FALSE
+"transcriptomics","Log2FC","KEGG_RIBOSOME",-0.37924,-1.43,0.0805,14672,0.313,"RPL22L1, RPS23, RPL26, RPL21, RPL13A, RPS24, RPL10A, RPL37A, RPS11, RPS27A, RPL35, RPL10, RPL26L1, RPL34, RPL27A, RPLP0, RPL11, RPL32, RPS8, RPL18, RPS27, RPL9, RPS20, RPS10, RPS6, RPL4, RPL5, RPL14, RPSA, RPS13, RPS7, RPS19, RSL24D1, RPS12, RPL6, RPS4Y1, RPS16, RPL17",1.09420411963213,0.504455662453552,FALSE
+"transcriptomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.42041,1.22,0.159,3761,0.738,"TRADD, TRAF6, DHX58, MAPK13, MAVS, IRF3, CXCL10, IKBKB, IFNB1, MAP3K1, TKFC, FADD, ISG15, IFIH1, DDX58, NLRX1, IL12B, CASP10, RELA, MAPK11, IKBKE",0.798602875679548,0.131943638176958,FALSE
+"transcriptomics","Log2FC","KEGG_RNA_DEGRADATION",-0.39068,-1.36,0.125,15014,0.372,"CNOT7, LSM2, EXOSC6, LSM1, LSM5, CNOT1, PNPT1, DCP1A, LSM7, EDC4, LSM3, EXOSC9, CNOT10, EXOSC5, EXOSC3, PAPOLA, TTC37, ZCCHC7, EXOSC10, MTREX, ENO1, DCP2, CNOT9, ENO3, EXOSC8, HSPA9, DCP1B, HSPD1",0.903089986991944,0.429457060118102,FALSE
+"transcriptomics","Log2FC","KEGG_RNA_POLYMERASE",-0.36582,-1.3,0.121,17492,0.435,"POLR3G, POLR3A, POLR2E, POLR3C, POLR2D, POLR1E",0.91721462968355,0.361510743045363,FALSE
+"transcriptomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.20795,-0.71,0.923,17399,1,"SCLY, MAT2A, MARS2, SEPHS1, TRMT11",0.0347982989740879,0,FALSE
+"transcriptomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.2741,0.799,0.78,4622,1,"LAMA3, TRAF6, RXRA, TRAF4, PIK3R2, LAMB3, LAMC2, IKBKB, PIK3CA, RXRB, MAX, ITGA3, E2F1, ITGA2B, CDKN1B, RELA, LAMA5, PIAS3, LAMB1, ITGA2, PIK3R3",0.10790539730952,0,FALSE
+"transcriptomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.44073,1.27,0.127,4358,0.786,"SNAP23, STX16, STX10, VAMP8, STX19, YKT6, STX17, VTI1B, TSNARE1, STX3, GOSR2, SNAP29, BET1, USE1, STX5, BET1L",0.896196279044043,0.104577453960592,FALSE
+"transcriptomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.24714,0.716,0.895,8272,1,"ARSA, SPTLC2, NEU1, ASAH1, PLPP3, DEGS2, SPHK2, GLB1, SPHK1, GBA, SGMS2, SGPP1, SPTLC1, ENPP7, UGCG, SMPD3, SMPD2, SGPP2, NEU2, SMPD1, UGT8",0.048176964684088,0,FALSE
+"transcriptomics","Log2FC","KEGG_SPLICEOSOME",-0.28279,-0.988,0.477,14820,0.769,"HSPA1A, SNRNP27, DDX23, LSM2, SF3A3, SF3B1, SNRPB, SNRPF, PRPF8, BCAS2, LSM5, PRPF3, THOC1, SRSF3, SF3A2, DDX39B, EIF4A3, LSM7, SF3B4, TCERG1, RBM22, U2AF1, LSM3, SNRNP40, SYF2, DDX5, HNRNPK, DHX15, HNRNPA1L2, BUD31, PQBP1, PRPF40A, THOC2, PRPF4, SNRPA1, RBM8A, ALYREF, CDC5L, RBM17, SRSF7, SNRPE, PRPF18, SNRPD2, CDC40, SNRPC, RBMX, SRSF1, HNRNPA3, HSPA8, HNRNPM, HNRNPA1, HNRNPC, SF3B5, MAGOHB, PPIH, HNRNPU, PPIE, TXNL4A, SRSF10",0.321481620959886,0.114073660198569,FALSE
+"transcriptomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44369,1.29,0.107,7075,0.846,"HK2, GYS1, GCK, GAA, PGM1, GANC, UGT2B17, GUSB, HK1, UXS1, PYGL, PGM2, ENPP1, MGAM, PYGB, AMY1A, UGP2, AGL",0.97061622231479,0.0726296369609765,FALSE
+"transcriptomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.61834,1.8,0.00564,5003,0.385,"MSMO1, DHCR24, LIPA, SC5D, SQLE, FDFT1, HSD17B7, CEL, NSDHL, DHCR7, LSS, TM7SF2",2.24872089601666,0.414539270491499,FALSE
+"transcriptomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38862,1.12,0.267,4669,0.711,"CYP11B1, CYP1B1, SULT2B1, SRD5A1, COMT, SRD5A3, CYP7B1, UGT2B17, HSD17B7, SULT1E1, CYP1A1, HSD17B8",0.573488738635425,0.148130399270234,FALSE
+"transcriptomics","Log2FC","KEGG_SULFUR_METABOLISM",0.55174,1.6,0.0275,5093,0.347,"SULT2B1, CHST12, SULT1A2, SUOX, SULT1A4, CHST11, SULT1E1, SULT1A3",1.56066730616974,0.459670525209126,FALSE
+"transcriptomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.21402,-0.746,0.894,18576,1,"SSB, GRIN2B",0.0486624812040823,0,FALSE
+"transcriptomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.22218,0.659,0.943,6205,0.987,"KCNB1, SCNN1A, ADCY4, TAS2R1, SCNN1G, TAS1R3, ADCY6, GNAS, TAS2R3, GRM4, TAS2R31, SCNN1B, ITPR3, PRKACA, TAS2R4, TAS2R38, TAS2R5",0.0254883072626717,0.00568284733036327,FALSE
+"transcriptomics","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.24456,0.712,0.884,3450,1,"GGT7, GGT6",0.0535477349869269,0,FALSE
+"transcriptomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.41775,1.21,0.185,5412,0.676,"MVK, HMGCS1, MVD, DHDDS, HMGCR",0.732828271596986,0.170053304058364,FALSE
+"transcriptomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21463,-0.754,0.826,15652,1,"SMAD7, TFDP1, RHOA, BMPR2, SMAD5, PITX2, BMP8B, PPP2CB, PPP2R1B, ID3, SMAD4, SKP1, SMURF2, BMPR1A, INHBE, SMAD9, BMP8A, ID2, TGFB1, CDKN2B, E2F5, ROCK2, BMP6, SMAD2",0.0830199526796178,0,FALSE
+"transcriptomics","Log2FC","KEGG_THYROID_CANCER",0.39121,1.13,0.27,3392,0.705,"CDH1, RXRA, MAPK3, RXRB, PPARG, BRAF, TCF7L1",0.568636235841013,0.151810883008601,FALSE
+"transcriptomics","Log2FC","KEGG_TIGHT_JUNCTION",0.33254,0.963,0.5,4350,0.864,"EPB41L1, PRKCD, AMOTL1, MYH14, CLDN8, CGN, CLDN9, CLDN7, CLDN4, F11R, TJP3, CRB3, TJP2, PRKCH, LLGL2, CLDN18, PRKCI, PARD6B, PATJ, CLDN11, CTTN, EXOC4, CLDN23, CLDN3, SRC, MYH15, MYL9, EXOC3, MAGI1, PRKCZ, OCLN",0.301029995663981,0.0634862575211067,FALSE
+"transcriptomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43206,1.25,0.145,6260,0.749,"TLR5, TRAF6, MAPK13, PIK3R2, IRF5, LBP, IRF3, TOLLIP, CXCL10, IKBKB, MAPK3, TLR3, IFNB1, PIK3CA, MYD88, FADD, CXCL11, CCL5, CD40, IL12B, CXCL9, TAB1, RELA, TLR1, MAPK11, IKBKE, IL6, TLR2, MAP3K8, IRAK4, TIRAP, TICAM1, PIK3R3, STAT1, IL12A, RAC1, TAB2, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB, NFKBIA, FOS, IRF7",0.838631997765025,0.125518182300534,FALSE
+"transcriptomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.25994,0.751,0.862,5698,0.993,"CAT, CYP1B1, GCDH, KMO, EHHADH, IL4I1, CYP1A1, MAOA, IDO1, HAAO, OGDHL",0.0644927341752872,0.00305075150461883,FALSE
+"transcriptomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.35999,1.04,0.393,1965,0.764,"PRKCD, HK2, PIK3R2, CACNA1D, SOCS1, GCK, IKBKB, MAPK3, INSR, PIK3CA",0.405607449624573,0.11690664142431,FALSE
+"transcriptomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",-0.22684,-0.791,0.732,16990,1,"PRF1, PTPRN, HSPD1",0.135488918941608,0,FALSE
+"transcriptomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.48583,1.41,0.0685,2773,0.638,"ADH7, ALDH3B2, HEMK1, TH, ALDH1A3, ALDH3B1, COMT, AOC2, GSTZ1, NAA80, LCMT1",1.16430942850757,0.195179321278838,FALSE
+"transcriptomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29483,0.852,0.705,6624,1,"PAK6, CBLC, VAV1, MAPK13, PIK3R2, VAV3, DLG1, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, NCK2, CBLB, PLCG1, RELA, CHP1, MAPK11, PPP3CA, PAK2, LCK, MAP3K8, CSF2, PIK3R3, CD4, NCK1, PAK1, PAK4, MAPK1, MAP2K7, NFATC1, PIK3R5, PIK3CB, NFKBIA, GSK3B, FOS, NFATC4, GRB2, CHP2",0.151810883008601,0,FALSE
+"transcriptomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29203,0.851,0.711,6099,0.994,"CBLC, UBOX5, ITCH, UBA7, TRAF6, UBE2H, PPIL2, SOCS1, FBXO2, SMURF1, PML, MAP3K1, FBXW7, UBE2L6, RHOBTB2, HERC1, HERC3, ANAPC2, CUL7, UBE2D4, CBLB, FBXO4, RNF7, MID1, SYVN1, UBA6, FBXW8, UBR5, UBE2C, PIAS3, KLHL13, UBE3B, UBE2W, HUWE1, NEDD4L, UBE2F, TRIM32, UBE2Q1, WWP2, DDB1, SIAH1, FZR1, UBE4A, UBE2E1, UBE3C, DET1, UBE2O, UBE2E2, STUB1, UBA3, ANAPC11, UBE2M, UBE2Z",0.148130399270234,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.54815,-1.97,0,13596,0.203,"VARS2, LARS2, BCAT1, PDHA1, IARS2",Inf,0.692503962086787,TRUE
+"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.42231,1.21,0.205,3822,0.676,"MCCC1, ACAA1, HIBADH, ACAD8, ALDH6A1, ABAT, HMGCL, HMGCS1, MCEE, ACADS, EHHADH, PCCB, IL4I1, AUH",0.688246138944246,0.170053304058364,FALSE
+"transcriptomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28813,0.84,0.732,4348,1,"PRKCD, PLA2G12A, KCNMB3, CACNA1D, PLA2G6, CALML3, PLA2G4B, ADORA2B, MAPK3, ADORA2A, PPP1CA, PRKCH, ADCY5, CYP4A22, PPP1CB, ADCY4, PLA2G10, PLA2G4E, BRAF, ADCY6, MYL9, PLA2G2C, EDNRA, KCNMB4, GNAS, GNAQ",0.135488918941608,0,FALSE
+"transcriptomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.27394,0.796,0.79,7785,1,"DYNLL2, AQP3, RAB5B, ARHGDIB, ADCY6, CREB3L4, GNAS, DYNC2LI1, DCTN5, CREB3L3, PRKACA, CREB3L2, RAB11B, RAB5C, CREB5, CREB3L1, CREB3, ADCY9, ADCY3, NSF, CREB1, RAB11A, PRKACG, DCTN1",0.102372908709559,0,FALSE
+"transcriptomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.37587,1.09,0.308,5894,0.757,"PLA2G12A, MAPK13, PIK3R2, PLCG2, RAC2, PLA2G6, PLA2G4B, NOS3, HSPB1, MAPK3, PIK3CA, PLA2G10, PLA2G4E, MAPKAPK3, PLCG1, SPHK2, PXN, SRC, CHP1, MAPK11, PPP3CA, PLA2G2C, BAD, VEGFA, PIK3R3, SPHK1, MAPKAPK2, RAC1, MAPK1, NFATC1, PIK3R5, PIK3CB",0.511449283499556,0.120904120499927,FALSE
+"transcriptomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.35881,1.03,0.411,7679,0.774,"ERO1A, PLCG2, ATP6V1C2, TJP2, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP6AP1, KDELR3, PLCG1, PDIA4, GNAS, TCIRG1, KCNQ1, ATP6V1G1, SEC61G, ATP6V0A4, PRKACA, KDELR2, ATP6V1C1, TJP1, ATP6V1E1, ADCY9, ADCY3, SEC61B, ATP6V0C, PRKACG, ATP6V1E2, ATP6V0E2",0.386158178123931,0.111259039317107,FALSE
+"transcriptomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.26233,0.756,0.851,3633,0.994,"MYH14, ITGB2, RAC2, DAG1, CD40, EIF4G1, CAV1, MYH15",0.0700704399154121,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.25146,0.732,0.892,2541,1,"WNT3A, WNT9A, TBL1XR1, WNT7B, DAAM1, FZD10, PORCN, WNT7A, RAC2, SENP2, WNT4, FRAT1, CTNNBIP1, DVL3, CAMK2G, FRAT2, CSNK1E, WNT10A, LRP5, CSNK1A1, EP300, VANGL2",0.0496351456238769,0,FALSE
+"proteomics","Log2FC","KEGG_ABC_TRANSPORTERS",-0.56716,-1.62,0.0638,8609,0.465,"ABCC5, ABCA1, ABCG1, ABCA10, ABCB1, ABCC10, ABCB7, ABCB5, ABCC1, ABCC4, ABCC6, ABCB4, ABCB10, ABCA7, ABCA3, ABCA13, ABCC2, ABCB11",1.19517932127884,0.332547047110046,FALSE
+"proteomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.42626,1.2,0.237,2845,0.633,"PIK3CD, RARA, RUNX1, LEF1, CCND1, KRAS, NRAS, FLT3, PIK3R2, PIK3CA, STAT3, IKBKB, HRAS, EIF4EBP1, MAPK3, GRB2, RPS6KB2, SOS2, TCF7L1, MAPK1",0.625251653989896,0.198596289982645,FALSE
+"proteomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.47199,1.3,0.143,1296,0.559,"RAC2, NECTIN4, CDH1, SNAI2, CTNND1, ACTN3, CTNNA1, NECTIN1, CTNNA2, CTNNB1, BAIAP2, ERBB2, RAC3, EP300, LMO7, PTPN6, PTPRF, EGFR, LEF1",0.844663962534938,0.252588192113577,FALSE
+"proteomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.31768,0.898,0.564,2689,0.975,"CD36, RXRA, RXRG, IRS1, ACSL4, ACSL1, PRKCQ, ACSL6, SLC2A1, ACSL5, STAT3, IKBKB, NFKBIA, PRKAB2, ACSL3",0.248720896016658,0.0109953843014632,FALSE
+"proteomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.24638,0.686,0.888,2010,0.993,"GLUL, ABAT, GLUD2, GFPT1, GPT2",0.051587034221399,0.00305075150461883,FALSE
+"proteomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.56793,1.6,0.051,3523,0.423,"SCNN1A, ATP1A2, PIK3CD, IRS1, PDPK1, KRAS, HSD11B2, PIK3R2, PIK3CA, MAPK3, SCNN1B, MAPK1, SFN, ATP1A3, ATP1A4, ATP1A1, PRKCG",1.29242982390206,0.373659632624958,FALSE
+"proteomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.58978,1.64,0.0361,2132,0.61,"FADS2, PLA2G12A, PLA2G2A, ACOX1, ACOX3",1.44249279809434,0.214670164989233,FALSE
+"proteomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",-0.26665,-0.78,0.759,8102,0.872,"PSEN1, NDUFV1, UQCRC1, COX7A2, NDUFA6, ERN1, NDUFC1, BAD, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, MAPT, ATP5PF, NDUFB4, HSD17B10, NDUFA3, ITPR2, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, IDE, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, PPP3CC, ITPR1, PLCB2, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5MC2, BACE2, CASP7, PLCB4, PSEN2",0.11975822410452,0.0594835150674328,FALSE
+"proteomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.38256,-1.14,0.266,7208,0.55,"AARS2, FARSB, FARS2, SARS2, LARS2, DARS2, YARS2, MTFMT, EARS2, WARS2, RARS2",0.575118363368933,0.259637310505756,FALSE
+"proteomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.27352,0.774,0.763,2412,0.997,"HK1, MPI, NPL, RENBP, PGM1, NAGK, GMPPA, GFPT1, HK2, GALT, PGM2, GALE",0.11747546204512,0.00130484168834428,FALSE
+"proteomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.34389,-0.999,0.433,10318,0.673,"NEFM, MAP2K6, MAPK11, SOD1, NEFL, PRPH, PRPH2, NEFH",0.363512103646635,0.171984935776023,FALSE
+"proteomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32022,0.896,0.562,3597,0.965,"CTSS, IFI30, CD74, CALR, LGMN, HSPA6, TAPBP, HSPA1A, PSME2, CREB1, PSME1, CTSB",0.250263684430939,0.0154726866562074,FALSE
+"proteomics","Log2FC","KEGG_APOPTOSIS",0.23693,0.671,0.919,2534,0.993,"IL1R1, BCL2, IL1RAP, ENDOD1, PIK3CD, CASP10, MYD88, PPP3R1, PPP3CA, PPP3CB, PPP3R2, PIK3R2, TP53, CASP6, PIK3CA, IKBKB, PRKAR1B, CAPN2, NFKBIA, ENDOG",0.0366844886138887,0.00305075150461883,FALSE
+"proteomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.4694,1.33,0.129,2120,0.577,"GGT5, PTGS2, PLA2G12A, EPHX2, ALOX5, GPX6, GPX7, PTGES, PLA2G2A, GPX1, GGT7, GPX3",0.889410289700751,0.238824186844269,FALSE
+"proteomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34932,0.983,0.459,2841,0.889,"GLUL, OAT, PRODH, PRODH2, GATM, ARG1, NOS3, CKMT1A, CKMT2, GLUD2, NOS1, P4HA2, NAGS, ARG2, P4HA1, PYCR3, MAOA, ASL, OTC, ALDH18A1",0.338187314462739,0.0510982390297863,FALSE
+"proteomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.33473,0.951,0.492,1866,0.91,"ITGB6, ITGB8, ACTN3, CTNNA1, ITGB4, CTNNA2, CTNNB1, DSC2, ITGA2, ITGA11, SGCG, LEF1, ITGA4, CACNA1F, GJA1, ITGA3, PKP2",0.30803489723264,0.0409586076789064,FALSE
+"proteomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.61182,-1.82,0.024,7847,0.415,"ALDH9A1, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",1.61978875828839,0.381951903287907,FALSE
+"proteomics","Log2FC","KEGG_AXON_GUIDANCE",0.46405,1.33,0.106,2598,0.577,"RAC2, PAK5, PAK6, NGEF, EPHA1, EPHB2, RGS3, ROBO2, NTN4, SEMA4B, NFATC4, EFNB2, EFNA1, SEMA7A, RAC3, PLXNB2, PPP3R1, SEMA3A, SEMA3C, PPP3CA, PPP3CB, PLXNA2, EPHB4, PPP3R2, EPHA4, SEMA4D, KRAS, NRAS, SLIT2, EPHB3, EPHB1, RHOA, NFATC1, SLIT1, SLIT3, RAC1, MET, LIMK2, HRAS, MAPK3, PLXNA1, ABLIM1, NFATC3, NTN1, NFATC2, RHOD",0.97469413473523,0.238824186844269,FALSE
+"proteomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",-0.25512,-0.74,0.815,10364,0.905,"WNT10A, GLI2, GLI3",0.0888423912600234,0.0433514207947967,FALSE
+"proteomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.41284,-1.16,0.279,7232,0.549,"GTF2A1, STON1, GTF2E2, TAF10, TBP, GTF2H3, GTF2A2, GTF2F2, GTF2H4, GTF2H1, TAF12, GTF2H2, GTF2F1, TAF13, TBPL1",0.554395796726402,0.260427655549908,FALSE
+"proteomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.24796,-0.739,0.841,9965,0.893,"POLL, NTHL1, MUTYH",0.0752040042020878,0.0491485411114536,FALSE
+"proteomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.28968,-0.833,0.642,7434,0.807,"SRM, ECHS1, MLYCD, ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",0.192464971931147,0.0931264652779296,FALSE
+"proteomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.35293,-1.04,0.339,9642,0.655,"HACD1, YOD1, PECR, ACOT7, ELOVL2",0.469800301796918,0.183758700008217,FALSE
+"proteomics","Log2FC","KEGG_BLADDER_CANCER",0.463,1.3,0.142,2596,0.559,"CDH1, VEGFA, THBS1, ERBB2, VEGFC, EGFR, CDK4, CCND1, KRAS, NRAS, CDKN1A, MMP2, TP53, HRAS, MAPK3, CDKN2A",0.847711655616944,0.252588192113577,FALSE
+"proteomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.29975,0.842,0.662,891,1,"ABAT, HMGCS1, ACSM3, BDH2",0.1791420105603,0,FALSE
+"proteomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.52452,1.46,0.0918,2561,0.653,"RAC2, DAPP1, CARD11, NFATC4, PIK3CD, RAC3, LYN, CD79A, PTPN6, PIK3AP1, PPP3R1, VAV1, PPP3CA, VAV2, PPP3CB, PPP3R2, KRAS, NRAS, CD81, NFATC1, PIK3R2, RAC1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, VAV3, GRB2, NFATC3, NFATC2, SOS2",1.03715731879876,0.185086818724926,FALSE
+"proteomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.24843,0.692,0.875,1708,1,"TNNC1, ERBB3, GNA15, TNNC2, NOS3, ERBB2, ERBB4, ATP2A3, PPP3R1, EGFR, PPP3CA, PPP3CB, PPP3R2, NOS1, PTK2B, CACNA1F, CACNA1A",0.0579919469776868,0,FALSE
+"proteomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.35378,0.989,0.426,840,0.889,"TNNC1, MYH7, ATP1A2, SLC9A1",0.370590400897281,0.0510982390297863,FALSE
+"proteomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.48094,1.37,0.106,793,0.611,"CLDN18, CLDN4, CLDN7, CDH15, CDH3, CDH5, SDC4, ITGAL, SDC1, ITGB8, ITGB2, CLDN3, CDH1, F11R, CLDN6, VCAN, JAM2, SDC2, NECTIN1, SDC3, CD274, ICAM2",0.97469413473523,0.213958789757446,FALSE
+"proteomics","Log2FC","KEGG_CELL_CYCLE",0.18042,0.515,0.994,2700,1,"FZR1, CDC6, WEE1, EP300, CDC7, CHEK2, ANAPC11, CDKN1C, CDK4, SKP2, CCND1, CCNB1, BUB1, CDKN1A, CCNA2, RBL1, CREBBP, TP53, PCNA, CHEK1, BUB1B, CDKN2A, HDAC1, ZBTB17",0.00261361560268669,0,FALSE
+"proteomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28479,-0.805,0.704,10271,0.851,"PLCB4, CXCL10, DOCK2, ADCY6, GNG7, SHC4, CCR10, CCR9, WAS, CXCL5, RASGRP2, CXCL14",0.152427340857888,0.0700704399154121,FALSE
+"proteomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.23803,0.661,0.904,2652,0.985,"PIK3CD, MECOM, RUNX1, CDK4, CCND1, KRAS, NRAS, CDKN1A, BCR, PIK3R2, TP53, PIK3CA, CTBP1, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, GRB2, SOS2, CDKN2A, HDAC1",0.0438315695246367,0.00656376950238827,FALSE
+"proteomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.51999,1.45,0.103,2428,0.632,"BHLHE41, PER2, NR1D1, CSNK1E, ARNTL",0.987162775294828,0.199282921717615,FALSE
+"proteomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.18745,-0.538,0.989,2896,1,"IDH1, SUCLG2, ACO1, DLD, ACLY, ACO2, DLST, PCK1, MDH2, MDH1, SDHA, SUCLG1, OGDHL, DLAT, OGDH, PC, SUCLA2, IDH3B, SDHB, CS, SDHC, IDH3A, PDHB, PDHA1, IDH3G, FH, SDHD, PCK2",0.0048037084028206,0,FALSE
+"proteomics","Log2FC","KEGG_COLORECTAL_CANCER",0.32298,0.901,0.565,2210,0.982,"RAC2, BCL2, CTNNB1, PIK3CD, RAC3, LEF1, CCND1, KRAS, RHOA, PIK3R2, TP53, RAC1, PIK3CA",0.247951552180562,0.00788851221305034,FALSE
+"proteomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.403,1.13,0.278,944,0.676,"CFI, CFB, SERPINA1, TFPI, FGG, FGB, SERPINA5, MASP1, PLAT, PLAU, SERPINC1, F3",0.555955204081924,0.170053304058364,FALSE
+"proteomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.39207,-1.17,0.27,8054,0.568,"APIP, GOT1, MAT2B, SDS, GOT2, CBS, MAT2A, MAT1A, MTAP, AMD1, CDO1",0.568636235841013,0.245651664288981,FALSE
+"proteomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.46198,-1.33,0.127,10106,0.632,"TNFRSF10A, TGFB1, BMPR2, CXCL10, INHBA, TNFRSF19, ACVR2A, CD70, TNFSF9, TGFB2, CD40, BMPR1A, TNFRSF10C, CCR10, CCR9, IL1A, IFNAR2, CXCL5, INHBE, CXCL14, PDGFRA",0.896196279044043,0.199282921717615,FALSE
+"proteomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.16559,0.465,0.998,2883,1,"CASP1, RIPK3, DDX58, IL18, IKBKB, NFKBIA, IKBKE, IL1B",0.000869458712628891,0,FALSE
+"proteomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",-0.30863,-0.874,0.556,10453,0.751,"ADCY6, TGFB2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.254925208417942,0.124360062995832,FALSE
+"proteomics","Log2FC","KEGG_DNA_REPLICATION",-0.20491,-0.611,0.932,2252,1,"PCNA, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, POLE4, POLD3, RFC4, MCM4, POLE3, MCM6, POLD1, MCM5, MCM7, RPA2, SSBP1, RNASEH2A, MCM3, POLE2, POLD2, FEN1, PRIM1, RPA1, MCM2, DNA2, RNASEH1, PRIM2, POLA1, POLA2, RNASEH2C, RNASEH2B",0.0305840876460186,0,FALSE
+"proteomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55702,1.6,0.044,2561,0.423,"ETS2, ETV6, EGFR, NOTCH3, KRAS, PIWIL2, MAPK3, GRB2, SOS2",1.35654732351381,0.373659632624958,FALSE
+"proteomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.35951,0.997,0.413,1430,0.901,"FMO5, GSTA5, ADH4, ADH7, FMO2, FMO4, MGST2, ALDH1A3, MGST1, ALDH3B1, FMO3",0.384049948343599,0.045275209020937,FALSE
+"proteomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42011,-1.22,0.232,9395,0.519,"GMPS, CYP3A5, UCK2, UMPS, NAT2, CYP3A7",0.6345120151091,0.284832642151542,FALSE
+"proteomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.43662,1.22,0.201,1082,0.624,"ITGB6, TNC, SDC4, CD36, SDC1, ITGB8, ITGB4, SDC2, LAMC2, LAMB3, THBS1, SDC3, CD47, ITGA2, ITGA11, LAMA3, LAMA4",0.696803942579511,0.204815410317576,FALSE
+"proteomics","Log2FC","KEGG_ENDOCYTOSIS",0.2991,0.835,0.704,2726,1,"EPN3, PSD4, ERBB3, ARRB1, CHMP2B, ASAP3, RAB11FIP1, RAB11FIP4, ERBB4, DNAJC6, ARAP3, EGFR, GRK2, AGAP1, TRAF6, PRKCZ, AGAP2, RAB22A, EHD2, PRKCI, PARD6G, ITCH, ARF6, RAB11B, RAB31, RAB11A, CHMP4C, MET, LDLRAP1, CHMP4A, CHMP4B, CHMP2A, CLTCL1, PARD6B, HRAS, EPS15, CBLB, IGF1R, HSPA6, VPS37B, RAB5B, PARD6A, EPN1",0.152427340857888,0,FALSE
+"proteomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.50929,1.41,0.104,2624,0.58,"CDH1, CTNNA1, CTNNA2, CTNNB1, ERBB2, PIK3CD, EGFR, LEF1, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, TCF7L1",0.98296666070122,0.236572006437063,FALSE
+"proteomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.31162,0.876,0.613,1141,0.971,"CXCL1, F11R, JAM2, MAPK12, MAPK13, LYN, EGFR",0.212539525481585,0.0127807700919951,FALSE
+"proteomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.41192,1.17,0.249,2561,0.666,"EREG, ERBB3, AREG, PAK5, PAK6, TGFA, ERBB2, PIK3CD, ERBB4, EGFR, GAB1, KRAS, NRAS, CDKN1A, PIK3R2, PIK3CA, HRAS, EIF4EBP1, MAPK3, CAMK2D, ABL2, CBLB, GRB2, RPS6KB2, SOS2",0.603800652904264,0.176525770829699,FALSE
+"proteomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.4815,1.36,0.109,2108,0.608,"LPCAT2, PLA2G12A, PAFAH2, PLA2G2A, LPCAT4, LPCAT1, PLPP3",0.962573502059376,0.216096420727265,FALSE
+"proteomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.299,0.853,0.635,2361,1,"ADH4, ADH7, ACSL4, ACAA1, ACSL1, ACOX1, CPT2, ACSL6, ADH1C, ACOX3, ACADM, ACSL5, ACADS",0.197226274708024,0,FALSE
+"proteomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.46449,1.33,0.143,2664,0.577,"RAC2, PRKCD, MAPK12, PIK3CD, MAPK13, PLA2G12A, RAC3, LYN, VAV1, LCP2, VAV2, PLA2G2A, PDPK1, KRAS, NRAS, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, SOS2, MAPK14",0.844663962534938,0.238824186844269,FALSE
+"proteomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3637,1.02,0.402,2557,0.853,"RAC2, PRKCD, AMPH, ASAP3, SCIN, PIK3CD, LYN, VAV1, GSN, MYO10, HCK, VAV2, MARCKS, MARCKSL1, PLA2G4F, ARF6, PTPRC, PIK3R2, PLPP3, RAC1, PIK3CA, LIMK2, MAPK3, VAV3, RPS6KB2",0.39577394691553,0.069050968832477,FALSE
+"proteomics","Log2FC","KEGG_FOCAL_ADHESION",0.29325,0.831,0.658,1355,0.97,"ITGB6, TNC, RAC2, BCL2, PAK5, PAK6, ITGB8, VEGFA, ACTN3, ITGB4, LAMC2, LAMB3, THBS1, CTNNB1, ERBB2, VEGFC, PIK3CD, RAC3, VAV1, ITGA2, ITGA11, LAMA3, LAMA4, EGFR, VAV2, PDPK1, CCND1",0.181774106386044,0.0132282657337552,FALSE
+"proteomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.38519,1.08,0.304,2050,0.734,"ALPI, ALPP, ALPG, FPGS, PTS",0.517126416391246,0.134303940083929,FALSE
+"proteomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.59056,1.64,0.044,2113,0.61,"ALDOB, FBP1, ALDOC, PFKFB4, MTMR7, HK1, FBP2, PFKFB2, MPI, GMPPA, MTMR1, HK2",1.35654732351381,0.214670164989233,FALSE
+"proteomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.35287,0.993,0.439,2908,0.895,"B4GALT1, HK1, PGM1, HK2, GAA, GALT, PGM2, GALE, UGP2, MGAM",0.357535479757879,0.048176964684088,FALSE
+"proteomics","Log2FC","KEGG_GAP_JUNCTION",-0.39068,-1.14,0.27,9590,0.55,"GNAI1, ITPR1, PLCB2, TUBA8, TUBA3C, TUBB6, GRM5, PLCB4, MAP2K5, ADCY6, TUBB2B, PDGFRA",0.568636235841013,0.259637310505756,FALSE
+"proteomics","Log2FC","KEGG_GLIOMA",-0.32991,-0.976,0.411,10540,0.658,"CDK6, SHC4, PDGFRA",0.386158178123931,0.181774106386044,FALSE
+"proteomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.28325,0.798,0.734,2603,1,"GGT5, GSTA5, MGST2, GPX6, GPX7, MGST1, GSTK1, GPX1, IDH2, GGT7, GPX3, MGST3, G6PD, ANPEP, GSTT2",0.134303940083929,0,FALSE
+"proteomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.32775,0.918,0.53,2176,0.968,"LIPC, LPL, MGLL, LIPG, DGKA, DGKH, MBOAT2, DGKB, PLPP3, DGAT1",0.275724130399211,0.0141246426916063,FALSE
+"proteomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.34171,0.951,0.489,3460,0.91,"PEMT, DGKA, LPCAT2, PLA2G12A, CDS1, DGKH, PLA2G2A, CHKA, LPCAT4, MBOAT2, LPCAT1, DGKB, LYPLA2, PLPP3, PISD, PCYT2, LPGAT1, GPD1L, MBOAT1, DGKZ, PLA2G4A, GPD2, CHKB, LPCAT3, DGKQ",0.31069114087638,0.0409586076789064,FALSE
+"proteomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.30658,-0.907,0.554,9064,0.727,"CBS, AGXT, ALAS1, PHGDH, PIPOX, PSAT1, MAOB, GLDC",0.25649023527157,0.138465589140962,FALSE
+"proteomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.45991,1.29,0.171,881,0.563,"ALDOB, PGAM2, FBP1, ALDOC, ADH4, ADH7, GALM, HK1, FBP2, ACSS2, ALDH1A3",0.767003889607846,0.249491605148654,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34596,-0.994,0.419,9904,0.667,"XYLT1, CSGALNACT2, CHST3, CHST7",0.377785977033705,0.175874166083451,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34182,0.951,0.481,3070,0.91,"HS6ST2, HS6ST1, XYLT2, EXT2, EXT1, EXTL3",0.317854923626168,0.0409586076789064,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66613,1.87,0.0122,2887,0.688,"B4GALT1, FUT8, B4GALT3, ST3GAL1, B3GNT2, B4GALT4",1.91364016932525,0.162411561764489,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.43357,-1.29,0.151,9910,0.551,"HEXA, IDUA, ARSB, HYAL1",0.821023052706831,0.258848401148215,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51004,-1.53,0.0609,7952,0.508,"HEXB, ST3GAL5, HEXA, B4GALNT1",1.21538270736712,0.294136287716081,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.56837,1.6,0.0467,725,0.423,"B3GALNT1, B3GALT5",1.33068311943389,0.373659632624958,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62329,1.76,0.0173,2178,0.804,"B3GNT3, FUT3, B4GALT1, B3GALT5, B4GALT3, ST3GAL4, B3GNT2",1.7619538968712,0.0947439512515487,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.25881,-0.775,0.742,8687,0.868,"PIGN, PIGQ, PIGB, PIGM, PIGX",0.129596094720973,0.0614802748235081,FALSE
+"proteomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.16598,0.465,0.997,4328,1,"AFMID, GLYCTK, ACO1, ACO2, MDH2, MTHFD2L, MDH1, MTHFD1",0.00130484168834428,0,FALSE
+"proteomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.23616,0.661,0.923,3427,0.985,"PRKCD, MAPK12, MAPK13, PLA2G12A, CGA, EGFR, PLA2G2A, KRAS, NRAS, PTK2B, CACNA1F, MAP3K1, MMP2, PLCB1, HRAS, MAPK3, CAMK2D, GRB2, SOS2, MAPK14, MAPK1, PLA2G4A, MMP14, GNA11, ADCY9, CDC42, CAMK2B, PLCB3, SOS1, ADCY5",0.0347982989740879,0.00656376950238827,FALSE
+"proteomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30481,-0.886,0.575,10364,0.756,"WNT10A, GLI2, GLI3",0.24033215531037,0.121478204498793,FALSE
+"proteomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.29233,0.811,0.697,1843,0.991,"IL1R1, CD36, CD9, ITGA2, ITGA4, ITGA3, FLT3, CD33",0.156767221901991,0.00392634551472468,FALSE
+"proteomics","Log2FC","KEGG_HISTIDINE_METABOLISM",-0.34944,-1.01,0.37,10443,0.665,"ALDH2, MAOB, ALDH7A1, ALDH3A1",0.431798275933005,0.177178354696895,FALSE
+"proteomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",-0.38362,-1.13,0.291,9496,0.537,"RAD50, MUS81, MRE11, RAD52",0.536107011014093,0.270025714300444,FALSE
+"proteomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.35692,-1.03,0.397,7298,0.643,"NDUFV2, COX7C, POLR2L, NDUFS4, SDHB, NDUFB5, POLR2I, COX4I1, POLR2A, SDHC, COX6B1, DCTN4, COX6A1, POLR2E, CYCS, DCTN2, DNAL1, TBP, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, POLR2H, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, BAX, NDUFA2, DCTN1, TFAM, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, HIP1, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, DNAH3, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, TGM2, ATP5F1C, SOD2, AP2A2, ITPR1, PLCB2, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, TBPL1, GRM5, PLCB4, BBC3, SOD1",0.401209493236885,0.191789027075778,FALSE
+"proteomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.32547,-0.956,0.469,10552,0.655,"TGFB2, PRKAA2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.328827157284917,0.183758700008217,FALSE
+"proteomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25705,0.733,0.841,3346,1,"IMPA2, INPP4B, PIK3CD, PIP4K2C, ALDH6A1, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1, ISYNA1, INPP5B, INPP5A, PIP4K2A, PI4KB, SYNJ2, PLCB3",0.0752040042020878,0,FALSE
+"proteomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.20113,0.572,0.977,2750,1,"FBP1, PIK3CD, HK1, FBP2, PTPRF, IRS1, PDPK1, KRAS, NRAS, PRKCZ, PYGB, PRKCI, EXOC7, MKNK1, PIK3R2, HK2, PIK3CA, PTPN1, PPP1R3D, IKBKB, PRKAR1B, HRAS, EIF4EBP1, MAPK3, RHEB, CBLB, GRB2, RPS6KB2, SOS2, PRKAB2, PYGL, GYS1",0.0101054362812269,0,FALSE
+"proteomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50265,-1.49,0.0621,10060,0.532,"ICOSLG, TGFB1, CD40, CCR10, CCR9",1.20690839982342,0.274088367704952,FALSE
+"proteomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27492,0.779,0.737,2561,0.998,"SPRY2, LIFR, PIK3CD, EP300, PTPN6, STAT2, IL13RA1, IFNGR1, CCND1, IRF9, STAT1, OSMR, STAT6, SPRY1, CREBBP, PIK3R2, JAK1, PIAS3, PIK3CA, STAT3, CBLB, GRB2, SOS2",0.132532512140949,0.000869458712628891,FALSE
+"proteomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.37967,1.04,0.366,2883,0.817,"ITGB2, PTGS2, MAPK12, MAPK13, MYD88, PTPN6, IFNGR1, STAT1, ITGA4, TRAF6, MARCKSL1, JAK1, MAPK3, NFKBIA, MAPK14, C3, MAPK1, IL1B",0.436518914605589,0.0877779434675845,FALSE
+"proteomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.50535,1.43,0.0869,809,0.569,"CLDN18, CLDN4, CLDN7, RAC2, CDH5, ITGAL, ITGB2, CLDN3, F11R, CLDN6, CTNND1, ACTN3, CTNNA1, JAM2, MAPK12, CTNNA2, CTNNB1, PIK3CD, MAPK13",1.06098022355133,0.244887733604929,FALSE
+"proteomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.6513,-1.99,0.0168,7847,0.247,"ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, YOD1, ALDH2, ALDH7A1, NAA80",1.77469071827414,0.607303046740334,TRUE
+"proteomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",-0.568,-1.68,0.0335,10332,0.494,"PLA2G6, CYP3A7",1.47495519296315,0.306273051076353,FALSE
+"proteomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",-0.22631,-0.656,0.934,9590,1,"GNAI1, ITPR1, PLCB2, GRM5, PLCB4, PLA2G6, PPP1R17",0.0296531237699066,0,FALSE
+"proteomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.24302,0.69,0.87,2407,0.998,"EP300, PPP3R1, PPP3CA, PPP3CB, PPP3R2, KRAS, NRAS, RPS6KA1, CREBBP, RPS6KA6, PLCB1, RPS6KA2, HRAS, MAPK3, CAMK2D",0.0604807473813815,0.000869458712628891,FALSE
+"proteomics","Log2FC","KEGG_LYSINE_DEGRADATION",-0.35898,-1.07,0.325,10138,0.63,"TMLHE, PIPOX, ALDH2, ALDH7A1, AADAT, BBOX1",0.488116639021126,0.200659450546418,FALSE
+"proteomics","Log2FC","KEGG_LYSOSOME",0.25134,0.699,0.882,1651,1,"CTSE, CTSH, AP1M2, CTSS, ACP5, LAMP3, NEU1, NPC2, NAPSA, CTSA, SLC11A2, GM2A, AP1B1, AP1S1, FUCA1, SGSH",0.0545314148681803,0,FALSE
+"proteomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",-0.30167,-0.88,0.566,9929,0.753,"TGFB3, DUSP16, MAPK8, FLNC, DDIT3, MKNK2, FGFR1, TGFB1, MAP2K5, PLA2G6, MAP2K6, MAPK11, MYC, NFKB2, TGFB2, ATF4, RELB, IL1A, CACNA2D2, DUSP4, CACNA2D1, MEF2C, FGF13, FGF2, RASGRP2, PDGFRA",0.247183568811729,0.123205023799299,FALSE
+"proteomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.73187,-2.15,0,9747,0.311,"HNF1A, HNF4A, NEUROD1, GCK, MNX1, PAX6",Inf,0.507239610973163,FALSE
+"proteomics","Log2FC","KEGG_MELANOGENESIS",0.30698,0.861,0.651,3523,0.994,"GNAO1, TYR, CTNNB1, WNT5B, EP300, LEF1, KRAS, NRAS, WNT11, DVL1, CREBBP, CREB3L2, CREB3L1, PLCB1, HRAS, MAPK3, CAMK2D, WNT5A, TCF7L1, MAPK1, GNAI2, DVL3, GNAI3, ADCY9, CAMK2B, PLCB3, ADCY5, CREB1, PRKCG",0.186419011431808,0.00261361560268669,FALSE
+"proteomics","Log2FC","KEGG_MELANOMA",-0.43,-1.26,0.17,10540,0.554,"CDK6, FGF13, FGF2, PDGFRA",0.769551078621726,0.25649023527157,FALSE
+"proteomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42413,-1.25,0.176,10663,0.525,"AKR1C1, GSTM2, AKR1C3, AKR1C2, GSTA4, ALDH3A1, CYP3A7",0.75448733218585,0.279840696594043,FALSE
+"proteomics","Log2FC","KEGG_MISMATCH_REPAIR",0.43847,1.25,0.173,4177,0.576,"PCNA, LIG1, MLH3, RFC5, POLD4, EXO1, RFC2, RFC3, RFC1, RPA3, POLD3, RFC4",0.761953896871205,0.239577516576788,FALSE
+"proteomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.42655,1.18,0.232,2845,0.661,"VEGFA, VEGFC, PIK3CD, CAB39, PDPK1, RPS6KA1, PIK3R2, RPS6KA6, HIF1A, PIK3CA, RPS6KA2, EIF4EBP1, MAPK3, RHEB, RPS6KB2, RICTOR, RPS6KA3, MAPK1",0.6345120151091,0.17979854051436,FALSE
+"proteomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.48135,1.35,0.129,2561,0.606,"RAC2, ITGAL, ITGB2, LCK, RAET1L, ULBP2, NFATC4, SH3BP2, ICAM2, PIK3CD, RAC3, PTPN6, PPP3R1, VAV1, LCP2, PPP3CA, VAV2, IFNGR1, PPP3CB, PPP3R2, KRAS, NRAS, PTK2B, ICAM1, NFATC1, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, NFATC3, NFATC2, SOS2",0.889410289700751,0.217527375833714,FALSE
+"proteomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.21798,-0.634,0.909,8815,1,"TACR1, LEPR, F2R, P2RY11, CTSG, GRM5, PRSS1",0.0414361167780325,0,FALSE
+"proteomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31617,0.889,0.575,2672,0.954,"ARHGDIB, BCL2, TP73, PRKCD, ZNF274, MAPK12, PIK3CD, MAPK13, IRS1, GAB1, PDPK1, MAP3K5, TRAF6, KRAS, NRAS, RPS6KA4, MAP3K1, RPS6KA1, MAGED1, RHOA, PIK3R2, RPS6KA6, TP53, RAC1, NTRK2, PIK3CA, IKBKB, RPS6KA2, HRAS, MAPK3, CAMK2D, NFKBIA, GRB2, SOS2, FRS2, MAPK14, SORT1",0.24033215531037,0.0204516252959049,FALSE
+"proteomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48857,-1.4,0.108,9003,0.575,"NMNAT3, NAMPT, NNT, NT5C, CD38, BST1, NNMT",0.96657624451305,0.24033215531037,FALSE
+"proteomics","Log2FC","KEGG_NITROGEN_METABOLISM",-0.39831,-1.16,0.232,9727,0.549,"CA14, CA2, CA12, CPS1, CA8",0.6345120151091,0.260427655549908,FALSE
+"proteomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43448,1.21,0.218,2883,0.628,"CASP5, CXCL1, MAPK12, TRIP6, MAPK13, CASP1, TRAF6, IL18, IKBKB, MAPK3, NAIP, NFKBIA, TAB3, MAPK14, CASP8, CCL13, MAPK1, IL1B",0.661543506395395,0.202040356262804,FALSE
+"proteomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.71762,-2.09,0.00529,9253,0.215,"NHEJ1, PRKDC, RAD50, MRE11, POLL",2.27654432796481,0.667561540084395,TRUE
+"proteomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.41063,1.16,0.254,2596,0.673,"RXRA, RXRG, TGFA, ERBB2, PIK3CD, EGFR, CDK4, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, CDKN2A",0.595166283380062,0.171984935776023,FALSE
+"proteomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.34018,0.957,0.496,3178,0.942,"DTX3L, EP300, JAG1, NOTCH3, NCOR2, DVL1, CREBBP, DTX2, CTBP1, NUMB, HDAC1, MAML3, DVL3, RBPJ, JAG2",0.304518323509803,0.0259490972071227,FALSE
+"proteomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.17811,-0.528,0.987,1956,0.992,"ERCC5, PCNA, RAD23B, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, CUL4A, POLE4, POLD3, RFC4, RBX1, CETN2, POLE3, DDB1, MNAT1, POLD1, ERCC6, RAD23A, ERCC4, RPA2, POLE2, POLD2, RPA1, CDK7, GTF2H5, ERCC3, DDB2, CUL4B, GTF2H3, ERCC2, CCNH, GTF2H4, GTF2H1, GTF2H2, ERCC1, ERCC8, XPC, XPA",0.00568284733036327,0.00348832784582135,FALSE
+"proteomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.47511,1.32,0.14,836,0.576,"MAN1C1, MGAT4A, ST6GAL1, B4GALT1, FUT8",0.853871964321762,0.239577516576788,FALSE
+"proteomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",-0.37643,-1.06,0.323,9870,0.632,"CNGB1, PDE1C",0.490797477668897,0.199282921717615,FALSE
+"proteomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53605,-1.57,0.0608,8075,0.492,"MTHFD1L, ATIC, MTHFD2, MTHFS, MTFMT, TYMS, MTHFR, GART, ALDH1L1",1.21609642072727,0.30803489723264,FALSE
+"proteomics","Log2FC","KEGG_OOCYTE_MEIOSIS",0.19709,0.561,0.989,3300,1,"MAPK12, PPP3R1, ANAPC11, PPP3CA, AR, AURKA, PPP3CB, PPP2R5E, CCNB1, PPP3R2, PPP2R5B, BUB1, RPS6KA1, RPS6KA6, RPS6KA2, MAPK3, CAMK2D, IGF1R, RPS6KA3, MAPK1, BTRC, YWHAB, ADCY9, PKMYT1, CAMK2B",0.0048037084028206,0,FALSE
+"proteomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.2091,-0.628,0.946,7256,1,"FUCA2, MAN2B1, HEXB, MAN2B2, AGA, MAN2C1, HEXA",0.0241088635982073,0,FALSE
+"proteomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.46085,-1.35,0.139,7298,0.631,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, COX15, ATP6V1A, COX4I1, SDHC, COX6B1, COX6A1, NDUFV1, UQCRC1, ATP6V1B2, COX7A2, NDUFA6, NDUFC1, PPA1, ATP6V0A2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, NDUFA11, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, ATP5MG, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5ME, ATP5MC2, COX11",0.856985199745905,0.199970640755866,FALSE
+"proteomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.59998,1.68,0.0252,1847,0.884,"GCNT3, GALNT3, GALNT12, GALNT6, ST6GALNAC1, GALNT8, GALNT13, GALNT7, B4GALT5, GALNT2, GALNT15, GALNT5, C1GALT1C1, GALNT4, ST3GAL1",1.59859945921846,0.0535477349869269,FALSE
+"proteomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.29693,0.837,0.678,1726,1,"TP73, SERPINB5, SESN3, THBS1, CHEK2, CDK4, CCND1, RCHY1, CCNB1, CDKN1A, EI24",0.168770306132937,0,FALSE
+"proteomics","Log2FC","KEGG_PANCREATIC_CANCER",0.39919,1.12,0.285,2405,0.685,"RAC2, VEGFA, TGFA, ERBB2, VEGFC, PIK3CD, RAC3, EGFR, CDK4, RALB, CCND1, STAT1, KRAS, PIK3R2, TP53, JAK1, RAC1, PIK3CA, STAT3, IKBKB, MAPK3",0.54515513999149,0.164309428507574,FALSE
+"proteomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.26633,0.737,0.814,2657,1,"BCAT2, PANK1, DPYD",0.0893755951107988,0,FALSE
+"proteomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.47609,-1.4,0.101,7298,0.575,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, UBE2J2, COX4I1, SLC18A1, SDHC, COX6B1, COX6A1, CYCS, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, UBE2G2, UBE2G1, HTRA2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, PARK7, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, UCHL1",0.995678626217357,0.24033215531037,FALSE
+"proteomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.24664,0.697,0.879,646,1,"LY96, CDH1, TUBA4A, CTNNB1",0.0560111249262281,0,FALSE
+"proteomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.24197,0.68,0.884,2654,0.991,"RAC2, BCL2, CDH1, PTGS2, VEGFA, CTNNA1, LAMC2, LAMB3, RXRA, RXRG, TRAF4, CTNNA2, CTNNB1, TGFA, ERBB2, WNT5B, VEGFC, PIK3CD, RAC3, EP300, MECOM, RARA, RUNX1, ITGA2, LAMA3, LAMA4, NCOA4, EGFR, CKS1B, CDK4, RALB, SKP2, AR, LEF1, CCND1, STAT1, TRAF6, KRAS, NRAS, CDKN1A, ITGA3, WNT11, DVL1, FLT3, MAX, RHOA, MMP2, BCR, CREBBP, PIK3R2, TP53, JAK1, RAC1, PIAS3, HIF1A, MET, SLC2A1, PIK3CA, CTBP1, STAT3, IKBKB, HRAS, MAPK3, LAMB1, WNT5A, NFKBIA, CBLB, GRB2, IGF1R, SOS2, CDKN2A, TCF7L1, HDAC1, PAX8",0.0535477349869269,0.00392634551472468,FALSE
+"proteomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39564,1.09,0.314,6667,0.741,"DCXR, UGP2, XYLB, UGDH, CRYL1, UGT2B11, UGT2B4, RPE, GUSB, AKR1B1",0.503070351926785,0.130181792020672,FALSE
+"proteomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50211,1.39,0.115,829,0.594,"ALDOB, FBP1, ALDOC, FBP2",0.939302159646388,0.226213555018806,FALSE
+"proteomics","Log2FC","KEGG_PEROXISOME",0.32858,0.937,0.497,2901,0.933,"FAR1, PXMP4, EPHX2, PEX13, MVK, ACSL4, ACOT8, ACAA1, AMACR, ACSL1, CAT, CRAT, ACOX1, SLC25A17, FAR2, SCP2, CROT, ACSL6, GSTK1, IDH2, ACOX3, ACSL5, PMVK, PEX7, NUDT12, ACSL3, ABCD3, IDH1, PXMP2",0.303643611266668,0.0301183562535,FALSE
+"proteomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",-0.44236,-1.29,0.184,10509,0.551,"MAOB, NAA80, ALDH3A1",0.735182176990464,0.258848401148215,FALSE
+"proteomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.26615,0.752,0.792,2260,1,"IMPA2, DGKA, INPP4B, PIK3CD, PIP4K2C, CDS1, DGKH, DGKB, PIK3R2, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1",0.101274818410506,0,FALSE
+"proteomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.41459,-1.22,0.203,8765,0.519,"BLVRA, HMBS, PPOX, EARS2, BLVRB, HMOX1, ALAS1, UROD, UROS, FECH",0.692503962086787,0.284832642151542,FALSE
+"proteomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.40642,1.15,0.247,1703,0.678,"CD36, PLTP, LPL, FADS2, FABP6, FABP2, RXRA, RXRG, SCD5, ACSL4, FABP3, APOC3, ACAA1, PDPK1, ACSL1, ACOX1, CPT2, SCP2, ACSL6, HMGCS2",0.607303046740334,0.168770306132937,FALSE
+"proteomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.44792,1.26,0.171,1638,0.588,"CYP7B1, AMACR, SCP2",0.767003889607846,0.230622673923862,FALSE
+"proteomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.32308,-0.967,0.487,9562,0.648,"RFX5, RFXAP, CD40, BLNK",0.312471038785366,0.188424994129407,FALSE
+"proteomics","Log2FC","KEGG_PRION_DISEASES",-0.62081,-1.8,0.0296,10295,0.366,"C7, SOD1, C9, NCAM1, IL1A, NCAM2, EGR1",1.52870828894106,0.436518914605589,FALSE
+"proteomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.25639,0.712,0.835,3263,1,"FZR1, MAPK12, PIK3CD, MAPK13, ANAPC11, CCNB1, KRAS, BUB1, CCNA2, RPS6KA1, PIK3R2, RPS6KA6, PIK3CA, RPS6KA2, MAPK3, IGF1R, MAPK14, RPS6KA3, MAPK1, GNAI2, GNAI3, CCNB3, ADCY9, PKMYT1",0.0783135245163979,0,FALSE
+"proteomics","Log2FC","KEGG_PROPANOATE_METABOLISM",-0.26044,-0.786,0.737,10443,0.875,"ALDH2, ALDH7A1, ACSS3",0.132532512140949,0.0579919469776868,FALSE
+"proteomics","Log2FC","KEGG_PROSTATE_CANCER",0.32384,0.909,0.546,2624,0.976,"BCL2, CTNNB1, TGFA, ERBB2, PIK3CD, EP300, EGFR, AR, LEF1, PDPK1, CCND1, KRAS, NRAS, CDKN1A, CREBBP, PDGFC, PIK3R2, CREB3L2, TP53, CREB3L1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, GRB2, IGF1R, SOS2, TCF7L1",0.262807357295263,0.0105501823333082,FALSE
+"proteomics","Log2FC","KEGG_PROTEASOME",0.2805,0.792,0.755,7310,0.995,"PSMB10, PSMB8, PSME2, PSME1, POMP, PSMB1, PSMB9, PSMA7, PSMA1, PSMA2, PSME3, PSMA8, PSMA3, PSMB2, PSMC6, PSMB3, PSMD7, PSME4, PSMA5, PSMB4, PSMA4, PSMD4, PSMD2, PSMB7, PSMD3, PSMD11, PSMC2, PSMC4, PSMC3, PSMC5, PSMF1, PSMD12, PSMD13, PSMA6, PSMC1, PSMB6, PSMD14, PSMD6, PSMD8, PSMD1, SEM1",0.122053048370812,0.00217691925427455,FALSE
+"proteomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.34994,-1.03,0.358,7823,0.643,"SEC61B, IMMP2L, SEC11C, SEC63, IMMP1L, SEC61A2",0.446116973356126,0.191789027075778,FALSE
+"proteomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.28081,0.785,0.752,3930,0.997,"ATP1A2, GLUD2, AQP1, SLC38A3, ATP1A3, ATP1A4, ATP1A1, SLC9A3, PCK1, ATP1B1",0.123782159408358,0.00130484168834428,FALSE
+"proteomics","Log2FC","KEGG_PURINE_METABOLISM",-0.26075,-0.762,0.777,7632,0.879,"PRIM2, PDE4D, POLA1, POLR3C, HPRT1, POLR2E, POLR3A, POLR3H, PDE8A, ENTPD4, GMPR2, POLA2, POLR2H, NUDT9, PNPT1, ATIC, NME2, ADCY3, ADCY8, PAPSS2, AK5, NUDT2, POLR3GL, GDA, POLR1E, GMPS, RRM2B, ADCY10, NPR2, GART, PFAS, NT5C, NME4, NUDT5, PDE3A, ADCY6, ENTPD1, PDE4A, NME1, NPR1, PDE1C, ENTPD8",0.109578981199086,0.0560111249262281,FALSE
+"proteomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.20888,-0.608,0.945,7564,0.988,"POLR2A, AK3, PRIM2, DHODH, DCTD, POLA1, POLR3C, POLR2E, POLR3A, POLR3H, ENTPD4, POLA2, POLR2H, PNPT1, NME2, DTYMK, NUDT2, TYMS, POLR3GL, POLR1E, CAD, RRM2B, DUT, UCK2, NT5C, UMPS, NME4, TXNRD1, ENTPD1, CTPS1, NME1, ENTPD8",0.0245681914907371,0.00524305541237188,FALSE
+"proteomics","Log2FC","KEGG_PYRUVATE_METABOLISM",-0.33889,-0.981,0.375,7380,0.663,"ACYP2, GRHPR, ACACA, PDHB, ALDH9A1, ME2, ALDH1B1, PDHA1, ACAT1, ALDH3A2, GLO1, PCK2, HAGH, ME3, ALDH2, ALDH7A1",0.425968732272281,0.178486471595227,FALSE
+"proteomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.26341,0.736,0.815,1559,1,"ITGB6, RAC2, ITGAL, PAK5, PAK6, ITGB8, ITGB2, ACTN3, ITGB4, BAIAP2, SCIN, MYH14, PIK3CD, PIP4K2C, SLC9A1, RAC3, VAV1, GSN, ITGA2, ITGA11, EGFR, SSH3, VAV2, FGD3, ITGA4, KRAS, NRAS",0.0888423912600234,0,FALSE
+"proteomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.43145,-1.26,0.171,7210,0.554,"PIK3R4, ATG4B, ULK1, ATG5, PIK3C3, GABARAPL1, ATG3, ATG7, ULK3, PRKAA2",0.767003889607846,0.25649023527157,FALSE
+"proteomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3892,1.08,0.34,2561,0.734,"PAK5, PAK6, VEGFA, TGFA, VEGFC, PIK3CD, EP300, GAB1, KRAS, NRAS, CREBBP, PIK3R2, RAC1, HIF1A, MET, SLC2A1, PIK3CA, HRAS, MAPK3, GRB2, SOS2",0.468521082957745,0.134303940083929,FALSE
+"proteomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.32703,-0.983,0.431,9197,0.674,"NLN, AGT, CTSG, ACE2",0.365522729839268,0.17134010346468,FALSE
+"proteomics","Log2FC","KEGG_RETINOL_METABOLISM",-0.40251,-1.17,0.241,10576,0.568,"ALDH1A2, ALDH1A1, CYP3A7",0.617982957425132,0.245651664288981,FALSE
+"proteomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.46483,1.31,0.135,593,0.577,"ACP5, MTMR7, TYR",0.869666231504994,0.238824186844269,FALSE
+"proteomics","Log2FC","KEGG_RIBOSOME",-0.54955,-1.66,0.0451,6763,0.457,"RPSA, RPS16, RPS26, MRPL13, RPL13, RPL11, RPS25, RPL37A, RPL35, RPS4X, RPL27, RPS21, RPS28, RPS27L, RPS15A, RPS2, RPL14, FAU, RPL23, RPL7A, RPL29, RPS29, RPL21, RPL5, RPL34, RPL22, RPS9, RPS3, RPS18, RPL17, RPL15, RPL8, RPL18A, RPS3A, RPS12, RPL28, RPS11, RPL36, RPS17, RPL36A, RPL36AL, RPL3, RPL13A, RPL32, RPL26, RPL27A, RPS8, RPL10A, RPS7, RPS24, RPL7, RPS23, RPL31, RPL9, RPS13, RPL35A, RPL18, RPL19, RPL24, RSL24D1, RPL4, RPS20, RPL6, RPL38, RPS6, RPL37, RPL26L1, RPS4Y1",1.34582345812204,0.34008379993015,FALSE
+"proteomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21434,0.597,0.964,1713,1,"ISG15, MAPK12, MAPK13, CASP10, DDX58, DHX58, TRAF6, MAP3K1",0.0159229660971692,0,FALSE
+"proteomics","Log2FC","KEGG_RNA_DEGRADATION",-0.43669,-1.29,0.158,7190,0.551,"TTC37, EXOSC3, EXOSC2, EXOSC4, DIS3, EXOSC9, EXOSC5, EXOSC7, LSM2, PNPT1, EXOSC10, EXOSC8, LSM1, EXOSC1, MTREX, ENO3, HSPD1, HSPA9, PARN, TENT4A, DCP2, MPHOSPH6, DCPS, DCP1B",0.801342913045577,0.258848401148215,FALSE
+"proteomics","Log2FC","KEGG_RNA_POLYMERASE",-0.42301,-1.24,0.186,5911,0.523,"POLR3F, POLR1B, POLR2D, POLR3K, POLR2B, POLR2G, POLR2C, POLR1A, POLR3B, POLR1C, POLR1D, POLR3D, POLR2L, POLR2I, POLR2A, POLR3C, POLR2E, POLR3A, POLR3H, POLR2H, POLR3GL, POLR1E",0.730487055782084,0.281498311132726,FALSE
+"proteomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",0.26182,0.733,0.814,2085,1,"GGT5, CTH, METTL6, GGT7",0.0893755951107988,0,FALSE
+"proteomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.31583,0.89,0.556,2488,0.966,"BCL2, PTGS2, LAMC2, LAMB3, RXRA, RXRG, TRAF4, PIK3CD, ITGA2, LAMA3, LAMA4, CKS1B, CDK4, SKP2, CCND1, TRAF6, ITGA3, MAX, PIK3R2, TP53, PIAS3, PIK3CA, IKBKB, LAMB1, NFKBIA",0.254925208417942,0.0150228735845067,FALSE
+"proteomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.25505,0.714,0.848,3653,1,"VAMP8, VAMP4, TSNARE1, BET1L, STX17, SNAP47, STX3, GOSR1, STX10, SNAP29, STX16, STX18, STX12, STX6, VTI1B, SNAP23",0.0716041477432862,0,FALSE
+"proteomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.29469,0.833,0.675,2465,0.992,"CERK, NEU1, UGT8, SGPP2, SPTLC2, GALC, PLPP3, DEGS1, SPTLC1",0.170696227168975,0.00348832784582135,FALSE
+"proteomics","Log2FC","KEGG_SPLICEOSOME",-0.44795,-1.31,0.131,6622,0.6,"BCAS2, SNRPD1, SNRPD2, USP39, SF3A2, PRPF6, LSM3, THOC2, SNW1, SRSF6, SYF2, PQBP1, HNRNPA1, U2AF2, ACIN1, SNRPB2, MAGOHB, SRSF7, PRPF40A, HSPA8, HNRNPC, SNRPC, PPIL1, THOC1, RBM25, CTNNBL1, ZMAT2, SNRNP200, PRPF38B, HNRNPK, PRPF31, PPIH, HNRNPM, EIF4A3, DDX46, DDX39B, HNRNPA3, SF3A3, SRSF9, U2AF1, SRSF1, DDX23, SRSF4, SNRPA, SNRNP27, EFTUD2, SRSF8, PRPF38A, TRA2B, SNRPD3, DHX16, PPIE, SNRPF, SRSF3, LSM2, ALYREF, RBM8A, RBM17, SRSF2, SF3B4, TCERG1, RBMX, PRPF8, CDC40, U2SURP, SMNDC1, WBP11, RBM22, SNRNP40, SLU7, PRPF18, TRA2A, BUD31, SNU13, TXNL4A, CHERP, HNRNPU",0.882728704344236,0.221848749616356,FALSE
+"proteomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44846,1.28,0.156,2989,0.565,"HK1, SI, PYGB, PGM1, HK2, GAA, PGM2, AGL, PYGL, GYS1, UGP2, MGAM, PGM2L1",0.806875401645538,0.247951552180562,FALSE
+"proteomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.72045,2.03,0.00909,2290,0.516,"DHCR24, MSMO1, FDFT1, CYP27B1, DHCR7, SC5D, SQLE, NSDHL, HSD17B7, CYP51A1, LSS",2.04143611677803,0.287350298372789,FALSE
+"proteomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44063,-1.31,0.157,10468,0.6,"AKR1D1, CYP21A2, AKR1C1, AKR1C3, AKR1C2, CYP3A7",0.804100347590766,0.221848749616356,FALSE
+"proteomics","Log2FC","KEGG_SULFUR_METABOLISM",0.57977,1.66,0.0375,1903,0.774,"SULT2B1, SULT1A3, CHST12",1.42596873227228,0.111259039317107,FALSE
+"proteomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.47545,-1.41,0.108,9770,0.649,"CTSG, C7, CD40, C9, C1S",0.96657624451305,0.187755303199631,FALSE
+"proteomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.39951,1.14,0.282,89,0.685,"SCNN1A",0.549750891680639,0.164309428507574,FALSE
+"proteomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.5101,1.44,0.0767,2497,0.579,"HMGCS1, MVK, HMGCR, HMGCS2, PDSS2, PMVK, FDPS",1.11520463605102,0.237321436272564,FALSE
+"proteomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.42677,-1.25,0.201,9929,0.525,"TGFB3, THBS4, THBS3, TGFB1, SMAD2, BMPR2, MYC, INHBA, FST, ACVR2A, TGFB2, BMPR1A, INHBE",0.696803942579511,0.279840696594043,FALSE
+"proteomics","Log2FC","KEGG_THYROID_CANCER",0.56509,1.61,0.039,2845,0.611,"CDH1, RXRA, RXRG, CTNNB1, NCOA4, LEF1, CCND1, KRAS, NRAS, TP53, HRAS, MAPK3, TCF7L1, PAX8, MAPK1",1.4089353929735,0.213958789757446,FALSE
+"proteomics","Log2FC","KEGG_TIGHT_JUNCTION",0.5679,1.6,0.0446,1947,0.423,"CLDN18, CLDN4, CLDN7, CRB3, MYH7, PRKCH, EPB41L1, CGN, CLDN3, F11R, CLDN6, TJP3, ACTN3, CTNNA1, PRKCD, JAM2, PATJ, CTNNA2, CTNNB1, MYH14, MYH7B, TJP2, LLGL2, CDK4, MAGI3, PRKCQ, CASK, KRAS, NRAS, PRKCZ, PRKCI, CTTN, PARD6G, YES1, CLDN11, EXOC3, MYL9, RHOA, EXOC4",1.35066514128786,0.373659632624958,FALSE
+"proteomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.24732,0.692,0.9,2883,1,"LY96, IRF5, MAPK12, PIK3CD, MAPK13, MYD88, STAT1, TRAF6, PIK3R2, RAC1, PIK3CA, IKBKB, MAPK3, NFKBIA, IKBKE, MAPK14, CASP8, MAPK1, IL1B",0.0457574905606751,0,FALSE
+"proteomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",-0.38666,-1.13,0.255,10040,0.537,"WARS2, ALDH2, MAOB, ALDH7A1, AADAT, KYNU",0.593459819566045,0.270025714300444,FALSE
+"proteomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",-0.31589,-0.917,0.5,10063,0.72,"MAPK8, GCK, SOCS2, SOCS4",0.301029995663981,0.142667503568732,FALSE
+"proteomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.44767,1.25,0.176,1073,0.576,"CPE, PTPRN2, ICA1",0.75448733218585,0.239577516576788,FALSE
+"proteomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.29251,0.822,0.677,2304,0.979,"ADH4, ADH7, TYR, HGD, ALDH1A3, ALDH3B1, METTL6, ADH1C, COMT, TAT, MIF",0.169411331314856,0.00921730819686218,FALSE
+"proteomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.50774,1.44,0.084,2664,0.579,"PAK5, PAK6, LCK, CARD11, MAPK12, NFATC4, PIK3CD, MAPK13, PTPN6, PPP3R1, VAV1, LCP2, CDK4, PPP3CA, VAV2, PDPK1, PPP3CB, PPP3R2, PRKCQ, KRAS, NRAS, RHOA, NFATC1, PTPRC, PIK3R2, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, VAV3, GRB2, NFATC3, NFATC2, SOS2, TEC, MAPK14",1.07572071393812,0.237321436272564,FALSE
+"proteomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18021,0.513,0.997,2223,1,"FZR1, UBE2C, UBA7, UBE2E3, ANAPC11, TRIM37, SKP2, RCHY1, MGRN1, UBOX5, UBE2L6, KEAP1, TRAF6, MAP3K1, UBE2O, ITCH, UBA6, PIAS3, BRCA1",0.00130484168834428,0,FALSE
+"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.33808,-0.97,0.423,7753,0.656,"PDHB, PDHA1, LARS2, BCAT1",0.373659632624958,0.18309616062434,FALSE
+"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.25067,0.718,0.857,2361,1,"ABAT, HMGCS1, ALDH6A1, ACAD8, ACAA1, BCAT2, HMGCS2, MCCC1, HIBADH, ACADM, DBT, ACADS",0.0670191780768018,0,FALSE
+"proteomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.285,-0.849,0.624,9514,0.789,"NPR2, ITPR1, PLCB2, ARHGEF11, ARHGEF1, PLCB4, PLA2G6, ADCY6, NPR1, CALD1, KCNMA1, PPP1R14A",0.204815410317576,0.10292299679058,FALSE
+"proteomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.2868,0.793,0.723,2159,1,"ARHGDIB, AQP3, DYNLL2, RAB11B, CREB3L2, CREB3L1, RAB11A",0.140861702705469,0,FALSE
+"proteomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.53564,1.51,0.0583,2664,0.571,"RAC2, PTGS2, VEGFA, HSPB1, MAPK12, NOS3, NFATC4, PIK3CD, MAPK13, PLA2G12A, RAC3, PPP3R1, PPP3CA, PLA2G2A, PPP3CB, PPP3R2, KRAS, NRAS, NFATC1, PIK3R2, MAPKAPK3, RAC1, PIK3CA, HRAS, MAPK3, NFATC3, NFATC2, MAPK14",1.23433144524099,0.243363891754152,FALSE
+"proteomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.14569,0.411,1,1695,1,"TJP2, ERO1A, PDIA4, KDELR3",0,0,FALSE
+"proteomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.40292,1.13,0.27,1355,0.676,"RAC2, MYH7, ITGAL, ITGB2, MYH14, MYH7B, RAC3, SGCG, CCND1",0.568636235841013,0.170053304058364,FALSE
+"proteomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.29792,0.831,0.676,2624,0.97,"RAC2, VANGL2, SFRP4, CTNNB1, NFATC4, WNT5B, DAAM1, RAC3, EP300, PPP3R1, CSNK1A1, TBL1XR1, PPP3CA, LEF1, CCND1, PPP3CB, PPP2R5E, PPP3R2, LRP5, PPP2R5B, SENP2, DKK1, WNT11, DVL1, RHOA, NFATC1, CREBBP, TP53, PLCB1, RAC1, CHD8, CTBP1, CSNK1E, CAMK2D, WNT5A, NFATC3, NFATC2, TCF7L1",0.170053304058364,0.0132282657337552,FALSE
+"metabolomics","Log2FC","alpha amino acids",-0.62759,-1.45,0.0911,172,0.175,"sarcosine, phosphocreatine, creatinine, dimethylglycine, citrulline, ornithine, homocysteine",1.040481623027,0.756961951313706,FALSE
+"metabolomics","Log2FC","acyl carnitines",-0.61528,-1.39,0.116,202,0.124,"hexanoylcarnitine, malonylcarnitine, propionylcarnitine",0.935542010773082,0.906578314837765,FALSE
diff --git a/Examples/Fig4/GSEA/GSEA_venn_diagram.pdf b/Examples/Fig4/GSEA/GSEA_venn_diagram.pdf
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diff --git a/Examples/Fig5/.DS_Store b/Examples/Fig5/.DS_Store
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diff --git a/Examples/Fig5/DMEA/DMEA_correlation_matrix.pdf b/Examples/Fig5/DMEA/DMEA_correlation_matrix.pdf
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diff --git a/Examples/Fig5/DMEA/DMEA_interactive_network.graph.html b/Examples/Fig5/DMEA/DMEA_interactive_network.graph.html
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--- /dev/null
+++ b/Examples/Fig5/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNVQxNDoxMjoyNSswMTowMDwveG1wOk1ld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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-25892a091b6696a95ad4" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/Fig5/DMEA/DMEA_mean_results.csv b/Examples/Fig5/DMEA/DMEA_mean_results.csv
new file mode 100644
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+"PLK inhibitor",1.80333333333333,0.410406302745625,0.000125094496019932,"transcriptomics, proteomics, metabolomics",3,2,"transcriptomics, proteomics",0.0103828431696544
+"MDM inhibitor",1.63333333333333,0.430155010819743,0.00240185384072756,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.0591170525636295
+"sterol demethylase inhibitor",1.57,0.383536178215302,0.0714892001869014,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.296680180775641
+"acetylcholine receptor agonist",1.46666666666667,0.32316146634977,0.0176719604230495,"transcriptomics, proteomics, metabolomics",3,0,"",0.133342974101191
+"serotonin receptor agonist",1.33333333333333,0.377403409276246,0.0448305100843667,"transcriptomics, proteomics, metabolomics",3,0,"",0.237996229004962
+"ATPase inhibitor",1.32533333333333,0.525761669707229,0.0136003308599986,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.125425273486654
+"DNA inhibitor",1.31,0.0721110255092797,0.102251409257752,"transcriptomics, proteomics, metabolomics",3,0,"",0.368994216017104
+"glucocorticoid receptor agonist",1.28666666666667,0.436157463920238,0.0358107941875691,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.228638147505249
+"tubulin polymerization inhibitor",1.197,0.322594172297021,0.1721661869189,"transcriptomics, proteomics, metabolomics",3,0,"",0.522719237289947
+"Aurora kinase inhibitor",1.19333333333333,0.183393929379719,0.189305750862537,"transcriptomics, proteomics, metabolomics",3,0,"",0.523745910719686
+"progesterone receptor agonist",1.19333333333333,0.153079500042734,0.221191162691551,"transcriptomics, proteomics, metabolomics",3,0,"",0.549711490227961
+"growth factor receptor inhibitor",1.16766666666667,0.31679067747226,0.221277719413408,"transcriptomics, proteomics, metabolomics",3,0,"",0.549711490227961
+"estrogen receptor agonist",1.12333333333333,0.204042479237372,0.303384496583465,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097
+"opioid receptor agonist",1.05466666666667,0.325062045359549,0.429045558690266,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694
+"dopamine receptor antagonist",1.01833333333333,0.409590445852114,0.381173921200214,"transcriptomics, proteomics, metabolomics",3,0,"",0.673136924672718
+"estrogen receptor antagonist",1.005,0.234467481753867,0.484273487044021,"transcriptomics, proteomics, metabolomics",3,0,"",0.71776248972596
+"serotonin receptor antagonist",1.00133333333333,0.207164990607326,0.52426304021773,"transcriptomics, proteomics, metabolomics",3,0,"",0.737522582001213
+"protein synthesis inhibitor",0.993,0.319995312465667,0.477995068875388,"transcriptomics, proteomics, metabolomics",3,0,"",0.71776248972596
+"mTOR inhibitor",0.895333333333333,0.124444097221738,0.743893978929366,"transcriptomics, proteomics, metabolomics",3,0,"",0.851338029910444
+"antioxidant",0.882666666666667,0.15007109426313,0.748767182933282,"transcriptomics, proteomics, metabolomics",3,0,"",0.851338029910444
+"androgen receptor antagonist",0.819333333333333,1.23770809698141,0.0826639540891386,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.326719437590405
+"PI3K inhibitor",0.720666666666667,0.23715887782947,0.923930343272636,"transcriptomics, proteomics, metabolomics",3,0,"",0.95857773114536
+"PARP inhibitor",0.704,1.13903819075569,0.232218095090246,"transcriptomics, proteomics, metabolomics",3,0,"",0.550688625499727
+"HCV inhibitor",0.59,1.77738572065829,0.0104616887246457,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.125425273486654
+"HMGCR inhibitor",0.573333333333333,1.55165503038959,0.0309329853363614,"transcriptomics, proteomics, metabolomics",3,0,"",0.2139531485765
+"CC chemokine receptor antagonist",0.524,1.29214859826569,0.225183020093382,"transcriptomics, proteomics, metabolomics",3,0,"",0.549711490227961
+"JAK inhibitor",0.515333333333333,1.08213923934646,0.512415532783372,"transcriptomics, proteomics, metabolomics",3,0,"",0.737522582001213
+"DNA polymerase inhibitor",0.47,0.953939201416946,0.703342416444445,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"FGFR inhibitor",0.463333333333333,1.36621130625293,0.215405789781722,"transcriptomics, proteomics, metabolomics",3,0,"",0.549711490227961
+"bacterial DNA gyrase inhibitor",0.454666666666667,0.969686719169306,0.703294635524819,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"PPAR receptor agonist",0.427,1.62258343391026,0.0458787911334866,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.237996229004962
+"FLT3 inhibitor",0.419,1.0417518898471,0.665197417567066,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"bacterial 50S ribosomal subunit inhibitor",0.407333333333333,1.31979594382364,0.273620253675792,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097
+"calcium channel blocker",0.377333333333333,0.939872509084787,0.784684981034233,"transcriptomics, proteomics, metabolomics",3,0,"",0.868384712344551
+"PDGFR tyrosine kinase receptor inhibitor",0.37,1.48798521498031,0.133385720980026,"transcriptomics, proteomics, metabolomics",3,0,"",0.461292285055922
+"adrenergic receptor antagonist",0.369,0.769968181160754,0.943562342962668,"transcriptomics, proteomics, metabolomics",3,0,"",0.965074520824202
+"microtubule inhibitor",0.345,1.0669812556929,0.678275859990291,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"NFkB pathway inhibitor",0.342,0.936131935145896,0.827779861636799,"transcriptomics, proteomics, metabolomics",3,0,"",0.892282188517589
+"bromodomain inhibitor",0.316666666666667,1.35078989237162,0.303831806224957,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097
+"topoisomerase inhibitor",0.266666666666667,1.46083309564554,0.165057639383912,"transcriptomics, proteomics, metabolomics",3,0,"",0.522719237289947
+"thymidylate synthase inhibitor",0.258,1.32469317202136,0.358871060838437,"transcriptomics, proteomics, metabolomics",3,0,"",0.648140658366191
+"retinoid receptor agonist",0.223333333333333,1.16336766902529,0.56211990806605,"transcriptomics, proteomics, metabolomics",3,0,"",0.777599206158036
+"ribonucleotide reductase inhibitor",0.184666666666667,1.26390875198067,0.424780641517515,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694
+"KIT inhibitor",0.176,1.49896897899856,0.180651456941812,"transcriptomics, proteomics, metabolomics",3,0,"",0.522719237289947
+"BCL inhibitor",0.164666666666667,1.10480103789476,0.68279660651095,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"potassium channel blocker",0.133666666666667,1.11756893896231,0.687244030386695,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"VEGFR inhibitor",0.123,1.35687029593841,0.308355862013669,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097
+"p38 MAPK inhibitor",-0.0913333333333333,1.33512745958329,0.40172387179447,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694
+"benzodiazepine receptor agonist",-0.151,1.02284065230123,0.822553610958305,"transcriptomics, proteomics, metabolomics",3,0,"",0.892282188517589
+"protein tyrosine kinase inhibitor",-0.284666666666667,1.00706024315,0.782497037222137,"transcriptomics, proteomics, metabolomics",3,0,"",0.868384712344551
+"tyrosine kinase inhibitor",-0.292333333333333,1.17883685611425,0.524233517323791,"transcriptomics, proteomics, metabolomics",3,0,"",0.737522582001213
+"DNA alkylating agent",-0.324666666666667,1.10597573813051,0.640493409764762,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"cyclooxygenase inhibitor",-0.333,0.758553887340906,0.958055663326781,"transcriptomics, proteomics, metabolomics",3,0,"",0.965074520824202
+"DNA synthesis inhibitor",-0.341333333333333,0.762239682339704,0.965074520824202,"transcriptomics, proteomics, metabolomics",3,0,"",0.965074520824202
+"histamine receptor antagonist",-0.344666666666667,1.23939716529179,0.413221228344381,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694
+"RET tyrosine kinase inhibitor",-0.35,1.85259277770372,0.0123562055061721,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.125425273486654
+"CDK inhibitor",-0.375666666666667,0.82054270658713,0.879743301655512,"transcriptomics, proteomics, metabolomics",3,0,"",0.936137103043686
+"TGF beta receptor inhibitor",-0.437333333333333,1.24362950002536,0.359210485359576,"transcriptomics, proteomics, metabolomics",3,0,"",0.648140658366191
+"phosphatase inhibitor",-0.443,1.01514481725515,0.659224725778365,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"glutamate receptor antagonist",-0.500333333333333,1.26089663863987,0.306163869191785,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097
+"src inhibitor",-0.507333333333333,1.15981435296056,0.417488106342018,"transcriptomics, proteomics, metabolomics",3,0,"",0.684822718678694
+"Abl kinase inhibitor",-0.51,1.24554365640069,0.336985272298288,"transcriptomics, proteomics, metabolomics",3,0,"",0.635676763653589
+"AKT inhibitor",-0.516,0.916377651407977,0.698125717587431,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"acetylcholine receptor antagonist",-0.571666666666667,1.03077850837769,0.477769778721304,"transcriptomics, proteomics, metabolomics",3,0,"",0.71776248972596
+"Bcr.Abl kinase inhibitor",-0.631666666666667,1.27101311296671,0.153374994382888,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.509204981351187
+"RAF inhibitor",-0.650666666666667,1.43419710407368,0.0691298987454567,"transcriptomics, proteomics, metabolomics",3,0,"",0.296680180775641
+"DNA methyltransferase inhibitor",-0.666666666666667,1.42619540503163,0.068753694326179,"transcriptomics, proteomics, metabolomics",3,0,"",0.296680180775641
+"adrenergic receptor agonist",-0.699,0.26481880597873,0.922539579505745,"transcriptomics, proteomics, metabolomics",3,0,"",0.95857773114536
+"HSP inhibitor",-0.805333333333333,0.475247654737331,0.715114405728945,"transcriptomics, proteomics, metabolomics",3,0,"",0.83597881233102
+"adenosine receptor antagonist",-0.842333333333333,1.54679873717731,0.0109167241558126,"transcriptomics, proteomics, metabolomics",3,0,"",0.125425273486654
+"cytochrome P450 inhibitor",-0.903,0.281607883412379,0.676593609045045,"transcriptomics, proteomics, metabolomics",3,0,"",0.833963150926985
+"sodium channel blocker",-0.956,0.410302327558594,0.47639547719143,"transcriptomics, proteomics, metabolomics",3,0,"",0.71776248972596
+"MEK inhibitor",-1.07833333333333,0.363034892721531,0.310694336047846,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097
+"AP inhibitor",-1.112,0.272088220987238,0.295542333019956,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097
+"ALK tyrosine kinase receptor inhibitor",-1.13666666666667,0.249866631092135,0.278711430888661,"transcriptomics, proteomics, metabolomics",3,0,"",0.599712323069097
+"glycogen synthase kinase inhibitor",-1.19166666666667,0.325051278005999,0.18263684194468,"transcriptomics, proteomics, metabolomics",3,0,"",0.522719237289947
+"vitamin D receptor agonist",-1.21766666666667,0.514525347610138,0.092438873796934,"transcriptomics, proteomics, metabolomics",3,0,"",0.348746660233888
+"MET inhibitor",-1.278,0.553328112425169,0.0679952828971801,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.296680180775641
+"phosphodiesterase inhibitor",-1.42333333333333,0.184481254693623,0.0436101520317822,"transcriptomics, proteomics, metabolomics",3,0,"",0.237996229004962
+"EGFR inhibitor",-1.50366666666667,0.587341751736869,0.0093541182753819,"transcriptomics, proteomics, metabolomics",3,1,"proteomics",0.125425273486654
+"HDAC inhibitor",-1.52333333333333,0.153731367434669,0.0152273870907784,"transcriptomics, proteomics, metabolomics",3,0,"",0.126387312853461
+"proteasome inhibitor",-1.68333333333333,0.0378593889720019,0.00284901458137974,"transcriptomics, proteomics, metabolomics",3,1,"metabolomics",0.0591170525636295
+"CHK inhibitor",-1.73333333333333,0.198578280114753,0.00199673170195349,"transcriptomics, proteomics, metabolomics",3,0,"",0.0591170525636295
diff --git a/Examples/Fig5/DMEA/DMEA_results.csv b/Examples/Fig5/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..7c015e9
--- /dev/null
+++ b/Examples/Fig5/DMEA/DMEA_results.csv
@@ -0,0 +1,250 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"transcriptomics","Pearson.est","EGFR inhibitor",-0.65533,-1.71,0.0258,1232,0.333,"GW.583340, BIBX.1382, lapatinib, tucatinib, tyrphostin.AG.1478, rociletinib, TAK.285, BIBU.1361, neratinib, XL.647, BMS.690514, PD.168393, PD.153035, ARRY.334543, icotinib, WZ8040, dacomitinib, osimertinib, poziotinib, erlotinib, afatinib, AZD8931, pelitinib, canertinib, gefitinib",1.58838029403677,0.47755576649368,FALSE
+"transcriptomics","Pearson.est","Abl kinase inhibitor",0.32026,0.813,0.684,326,0.753,"GZD824, KW.2449, ponatinib, nilotinib, flumatinib",0.164943898279884,0.123205023799299,FALSE
+"transcriptomics","Pearson.est","acetylcholine receptor agonist",0.68226,1.71,0.0257,320,0.378,"oxiracetam, pilocarpine, tremorine, xanomeline",1.59006687666871,0.422508200162775,FALSE
+"transcriptomics","Pearson.est","acetylcholine receptor antagonist",-0.5322,-1.39,0.129,1021,0.508,"dicycloverine, darifenacin, diphemanil",0.889410289700751,0.294136287716081,FALSE
+"transcriptomics","Pearson.est","adenosine receptor antagonist",-0.68287,-1.78,0.0229,1442,0.331,"MRS.1220, CGS.15943",1.64016451766011,0.480172006224281,FALSE
+"transcriptomics","Pearson.est","adrenergic receptor agonist",-0.16807,-0.442,0.993,1390,0.993,"A61603",0.00305075150461883,0.00305075150461883,FALSE
+"transcriptomics","Pearson.est","adrenergic receptor antagonist",-0.19743,-0.502,0.975,1195,1,"metoprolol, atenolol...., RS.17053, pindolol",0.0109953843014632,0,FALSE
+"transcriptomics","Pearson.est","AKT inhibitor",-0.40618,-1.06,0.397,1036,0.744,"uprosertib, MK.2206, AZD5363, GDC.0068, CCT128930, A.674563, triciribine, GSK2110183",0.401209493236885,0.128427064454121,FALSE
+"transcriptomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.35397,-0.92,0.519,1158,0.839,"CEP.37440, GW.788388, lorlatinib, NVP.TAE684, AP26113",0.284832642151542,0.0762380391712997,FALSE
+"transcriptomics","Pearson.est","androgen receptor antagonist",0.51325,1.33,0.156,403,0.74,"RU.58841, bicalutamide, nilutamide",0.806875401645538,0.130768280269024,FALSE
+"transcriptomics","Pearson.est","antioxidant",0.35423,0.888,0.563,190,0.674,"mesna, trolox",0.249491605148654,0.17134010346468,FALSE
+"transcriptomics","Pearson.est","AP inhibitor",-0.43104,-1.12,0.296,968,0.728,"LCL.161, embelin, GDC.0152, tanshinone.i, birinapant",0.528708288941061,0.137868620686963,FALSE
+"transcriptomics","Pearson.est","ATPase inhibitor",0.38535,0.976,0.468,409,0.687,"evodiamine, ouabain, omeprazole, oligomycin.a, digitoxigenin, digitoxin",0.329754146925876,0.16304326294045,FALSE
+"transcriptomics","Pearson.est","Aurora kinase inhibitor",0.39912,1.05,0.39,400,0.661,"ENMD.2076, GSK1070916, PHA.680632, KW.2449, AMG900, barasertib, CCT137690, danusertib, AT.9283",0.408935392973501,0.17979854051436,FALSE
+"transcriptomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.57175,1.47,0.0938,280,0.74,"valnemulin, radezolid, azalomycin.b",1.02779716162094,0.130768280269024,FALSE
+"transcriptomics","Pearson.est","bacterial DNA gyrase inhibitor",0.45254,1.17,0.28,289,0.647,"novobiocin, nadifloxacin, norfloxacin, finafloxacin",0.552841968657781,0.1890957193313,FALSE
+"transcriptomics","Pearson.est","BCL inhibitor",0.42122,1.06,0.383,283,0.69,"venetoclax, TW.37, navitoclax",0.416801226031377,0.161150909262745,FALSE
+"transcriptomics","Pearson.est","Bcr.Abl kinase inhibitor",0.28362,0.734,0.787,326,0.805,"GZD824, ponatinib, nilotinib, flumatinib",0.104025267640935,0.0942041196321315,FALSE
+"transcriptomics","Pearson.est","benzodiazepine receptor agonist",-0.28516,-0.73,0.754,975,0.895,"CGS.20625, nefiracetam, bentazepam, indiplon, temazepam, lorazepam, gamma.aminobutyric.acid",0.122628654130226,0.048176964684088,FALSE
+"transcriptomics","Pearson.est","bromodomain inhibitor",0.46718,1.18,0.268,387,0.656,"I.BET.762, PFI.1, bromosporine",0.571865205971211,0.18309616062434,FALSE
+"transcriptomics","Pearson.est","calcium channel blocker",0.44995,1.15,0.276,224,0.605,"carboxyamidotriazole, cinnarazine, efonidipine.monoethanolate",0.559090917934782,0.218244625347531,FALSE
+"transcriptomics","Pearson.est","CC chemokine receptor antagonist",0.49081,1.26,0.198,515,0.66,"RS.504393, UNBS.5162, PF.04136309, ZK811752, SB.225002",0.703334809738469,0.180456064458131,FALSE
+"transcriptomics","Pearson.est","CDK inhibitor",0.20715,0.534,0.974,257,0.963,"PHA.848125, BMS.265246, ribociclib, R547, indisulam",0.0114410431213845,0.0163737128754655,FALSE
+"transcriptomics","Pearson.est","CHK inhibitor",-0.69447,-1.8,0.0199,1067,0.574,"LY2603618, AZD7762, SCH.900776, LY2606368, CHIR.124",1.70114692359029,0.241088107602027,FALSE
+"transcriptomics","Pearson.est","cyclooxygenase inhibitor",-0.36632,-0.935,0.512,1319,0.857,"tryptanthrin, phenylbutazone, pterostilbene, FR.122047, FK.3311, naproxen",0.290730039024169,0.0670191780768018,FALSE
+"transcriptomics","Pearson.est","cytochrome P450 inhibitor",-0.35354,-0.912,0.547,1221,0.813,"itraconazole, morin",0.262012673666569,0.0899094544059319,FALSE
+"transcriptomics","Pearson.est","DNA alkylating agent",0.36203,0.927,0.52,144,0.678,"carboplatin, temozolomide, carmustine, cyclophosphamide",0.283996656365201,0.168770306132937,FALSE
+"transcriptomics","Pearson.est","DNA inhibitor",0.51362,1.29,0.186,469,0.728,"valrubicin, carboplatin, carmustine, teroxirone, tirapazamine, mechlorethamine, pibenzimol, bendamustine, sangivamycin, metronidazole, nimorazole, oxaliplatin",0.730487055782084,0.137868620686963,FALSE
+"transcriptomics","Pearson.est","DNA methyltransferase inhibitor",0.38659,0.98,0.45,163,0.7,"decitabine, disulfiram",0.346787486224656,0.154901959985743,FALSE
+"transcriptomics","Pearson.est","DNA polymerase inhibitor",0.38116,0.97,0.461,270,0.678,"trifluridine, idoxuridine, foscarnet",0.336299074610352,0.168770306132937,FALSE
+"transcriptomics","Pearson.est","DNA synthesis inhibitor",-0.29226,-0.748,0.76,1419,0.942,"estramustine.phosphate, altretamine",0.119186407719209,0.0259490972071227,FALSE
+"transcriptomics","Pearson.est","dopamine receptor antagonist",0.3723,0.944,0.472,88,0.704,"thioproperazine, paliperidone, raclopride",0.326058001365912,0.152427340857888,FALSE
+"transcriptomics","Pearson.est","estrogen receptor agonist",0.5063,1.3,0.181,244,0.759,"ethinyl.estradiol, estrone, levonorgestrel",0.742321425130815,0.11975822410452,FALSE
+"transcriptomics","Pearson.est","estrogen receptor antagonist",0.29531,0.755,0.741,527,0.807,"danazol, clomifene, tamoxifen",0.130181792020672,0.0931264652779296,FALSE
+"transcriptomics","Pearson.est","FGFR inhibitor",0.51738,1.35,0.157,97,0.749,"regorafenib, dovitinib, nintedanib",0.804100347590766,0.125518182300534,FALSE
+"transcriptomics","Pearson.est","FLT3 inhibitor",0.50275,1.28,0.203,272,0.659,"sorafenib, dovitinib, TG.101348, ENMD.2076, KW.2449, ponatinib, tyrphostin.AG.1296",0.692503962086787,0.18111458540599,FALSE
+"transcriptomics","Pearson.est","glucocorticoid receptor agonist",0.41693,1.05,0.382,612,0.661,"fluticasone.propionate, triamcinolone, halobetasol.propionate, desonide, dexamethasone.acetate, prednisolone.hemisuccinate, beclomethasone.dipropionate, rimexolone, prednisolone, ciclesonide, difluprednate, methylprednisolone, fludroxycortide, halcinonide, prednisolone.acetate, fluocinolone.acetonide",0.417936637088291,0.17979854051436,FALSE
+"transcriptomics","Pearson.est","glutamate receptor antagonist",-0.40723,-1.03,0.393,1041,0.756,"CPP, ACDPP, SIB.1757, JNJ.16259685, LY456236, kynurenic.acid",0.405607449624573,0.121478204498793,FALSE
+"transcriptomics","Pearson.est","glycogen synthase kinase inhibitor",-0.4128,-1.07,0.36,1365,0.776,"indirubin, GSK.3.inhibitor.IX",0.443697499232713,0.110138278741812,FALSE
+"transcriptomics","Pearson.est","growth factor receptor inhibitor",0.38081,0.943,0.489,39,0.687,"PHA.848125",0.31069114087638,0.16304326294045,FALSE
+"transcriptomics","Pearson.est","HCV inhibitor",0.59647,1.53,0.0789,133,0.799,"narlaprevir, mericitabine",1.10292299679058,0.0974532206860086,FALSE
+"transcriptomics","Pearson.est","HDAC inhibitor",-0.64554,-1.7,0.0287,1274,0.263,"PCI.24781, M.344, panobinostat, romidepsin, tacedinaline, SB.939, JNJ.26481585, mocetinostat, nexturastat.a",1.54211810326601,0.580044251510242,FALSE
+"transcriptomics","Pearson.est","histamine receptor antagonist",-0.29307,-0.764,0.737,1131,0.955,"BF2.649, astemizole, lafutidine, famotidine, chloropyramine",0.132532512140949,0.0199966284162537,FALSE
+"transcriptomics","Pearson.est","HMGCR inhibitor",0.68253,1.73,0.0143,284,0.445,"fluvastatin, pitavastatin, mevastatin, atorvastatin, lovastatin",1.84466396253494,0.351639989019068,FALSE
+"transcriptomics","Pearson.est","HSP inhibitor",-0.22397,-0.591,0.92,1415,0.99,"KW.2478",0.0362121726544447,0.00436480540245009,FALSE
+"transcriptomics","Pearson.est","JAK inhibitor",0.45899,1.16,0.287,183,0.612,"AZD1480, TG.101348, WHI.P154, AZ960, baricitinib, filgotinib",0.542118103266008,0.213248577854439,FALSE
+"transcriptomics","Pearson.est","KIT inhibitor",0.47392,1.23,0.237,184,0.649,"sorafenib, regorafenib, masitinib, OSI.930, pazopanib",0.625251653989896,0.187755303199631,FALSE
+"transcriptomics","Pearson.est","MDM inhibitor",0.5324,1.38,0.144,57,0.819,"idasanutlin, nutlin.3",0.84163750790475,0.0867160982395816,FALSE
+"transcriptomics","Pearson.est","MEK inhibitor",-0.36084,-0.941,0.492,1384,0.894,"PD.98059, BIX.02188",0.30803489723264,0.0486624812040823,FALSE
+"transcriptomics","Pearson.est","MET inhibitor",-0.49285,-1.3,0.197,1427,0.497,"INC.280",0.705533773838407,0.303643611266668,FALSE
+"transcriptomics","Pearson.est","microtubule inhibitor",-0.33844,-0.887,0.579,1335,0.819,"colchicine, estramustine.phosphate",0.237321436272564,0.0867160982395816,FALSE
+"transcriptomics","Pearson.est","mTOR inhibitor",0.39799,1.01,0.426,507,0.668,"ku.0063794, voxtalisib, torin.1, AZD2014, MLN0128, NVP.BEZ235, WYE.354, XL388, LY303511, PF.04691502, GSK2126458, everolimus, AZD8055, SB.2343, WYE.125132",0.370590400897281,0.175223537524454,FALSE
+"transcriptomics","Pearson.est","NFkB pathway inhibitor",-0.2821,-0.732,0.758,867,0.927,"BAY.11.7082, parthenolide, parthenolide...., BAY.11.7085, Ro.106.9920, tyloxapol, bindarit, IKK.2.inhibitor.V",0.120330794367946,0.0329202658555029,FALSE
+"transcriptomics","Pearson.est","opioid receptor agonist",0.56438,1.43,0.136,123,0.762,"trimebutine, salvinorin.a",0.866461091629782,0.1180450286604,FALSE
+"transcriptomics","Pearson.est","p38 MAPK inhibitor",-0.32354,-0.834,0.652,1191,0.876,"SB.239063, TAK.715, CMPD.1",0.18575240426808,0.0574958938319193,FALSE
+"transcriptomics","Pearson.est","PARP inhibitor",0.49539,1.28,0.19,415,0.659,"olaparib, PJ.34, talazoparib, niraparib",0.721246399047171,0.18111458540599,FALSE
+"transcriptomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.53283,1.37,0.147,199,0.766,"sorafenib, regorafenib, dovitinib, linifanib, masitinib, nintedanib, axitinib, crenolanib, pazopanib, CP.673451",0.832682665251824,0.115771230367396,FALSE
+"transcriptomics","Pearson.est","phosphatase inhibitor",-0.51672,-1.34,0.175,1375,0.481,"mycophenolate.mofetil, BVT.948",0.756961951313706,0.317854923626168,FALSE
+"transcriptomics","Pearson.est","phosphodiesterase inhibitor",-0.56107,-1.47,0.118,1297,0.434,"enoximone, zardaverine, cilostamide, GSK256066",0.928117992693875,0.362510270487489,FALSE
+"transcriptomics","Pearson.est","PI3K inhibitor",0.29742,0.753,0.754,446,0.794,"GDC.0941, voxtalisib, NVP.BEZ235, ZSTK.474, LY303511, TG.100713, PI3K.IN.2, PF.04691502, alpelisib, CH5132799, GSK2126458, taselisib",0.122628654130226,0.100179497572904,FALSE
+"transcriptomics","Pearson.est","PLK inhibitor",0.79215,2.06,0.00378,253,0.0743,"volasertib, NMS.1286937, GW.843682X, rigosertib, BI.2536, GSK461364",2.42250820016277,1.12901118623942,TRUE
+"transcriptomics","Pearson.est","potassium channel blocker",0.34794,0.89,0.567,43,0.687,"ML133",0.246416941107093,0.16304326294045,FALSE
+"transcriptomics","Pearson.est","PPAR receptor agonist",-0.51347,-1.34,0.165,1010,0.481,"S26948, clofibrate, oleoylethanolamide, GW.501516, pterostilbene",0.782516055786094,0.317854923626168,FALSE
+"transcriptomics","Pearson.est","progesterone receptor agonist",0.40307,1.02,0.412,339,0.672,"nomegestrol.acetate, danazol, levonorgestrel, melengestrol.acetate, tanaproget",0.385102783966865,0.172630726946175,FALSE
+"transcriptomics","Pearson.est","proteasome inhibitor",-0.63601,-1.64,0.0527,1283,0.244,"oprozomib, ONX.0914, ixazomib.citrate",1.27818938478745,0.612610173661271,FALSE
+"transcriptomics","Pearson.est","protein synthesis inhibitor",0.25163,0.629,0.882,219,0.909,"anguidine, harringtonine, mercaptopurine",0.0545314148681803,0.0414361167780325,FALSE
+"transcriptomics","Pearson.est","protein tyrosine kinase inhibitor",-0.26517,-0.685,0.851,1153,0.922,"CP.724714, rheochrysidin, NVP.TAE226",0.0700704399154121,0.0352690789463706,FALSE
+"transcriptomics","Pearson.est","RAF inhibitor",0.36988,0.938,0.52,28,0.679,"sorafenib, regorafenib",0.283996656365201,0.168130225719498,FALSE
+"transcriptomics","Pearson.est","RET tyrosine kinase inhibitor",0.68916,1.76,0.0232,28,0.546,"sorafenib, regorafenib",1.6345120151091,0.262807357295263,FALSE
+"transcriptomics","Pearson.est","retinoid receptor agonist",0.35153,0.899,0.535,33,0.69,"bexarotene",0.271646217978772,0.161150909262745,FALSE
+"transcriptomics","Pearson.est","ribonucleotide reductase inhibitor",0.47463,1.23,0.238,518,0.649,"cladribine, fludarabine.phosphate, cytarabine, triapine, pentostatin",0.623423042943488,0.187755303199631,FALSE
+"transcriptomics","Pearson.est","serotonin receptor agonist",0.59318,1.51,0.0709,454,0.732,"zolmitriptan, NAN.190, SR.57227A, ipsapirone, aripiprazole",1.14935376481693,0.135488918941608,FALSE
+"transcriptomics","Pearson.est","serotonin receptor antagonist",0.48277,1.22,0.247,77,0.636,"SB.216641, SB.200646, paliperidone",0.607303046740334,0.196542884351586,FALSE
+"transcriptomics","Pearson.est","sodium channel blocker",-0.48589,-1.29,0.192,1358,0.47,"lappaconite, benzethonium, cibenzoline",0.71669877129645,0.327902142064283,FALSE
+"transcriptomics","Pearson.est","src inhibitor",0.30204,0.772,0.723,86,0.799,"KX2.391, masitinib",0.140861702705469,0.0974532206860086,FALSE
+"transcriptomics","Pearson.est","sterol demethylase inhibitor",0.46208,1.16,0.3,358,0.612,"lanoconazole, chlormidazole, sulconazole, ketoconazole, posaconazole",0.522878745280338,0.213248577854439,FALSE
+"transcriptomics","Pearson.est","TGF beta receptor inhibitor",0.35971,0.921,0.536,142,0.672,"adaprev",0.27083521030723,0.172630726946175,FALSE
+"transcriptomics","Pearson.est","thymidylate synthase inhibitor",0.46289,1.18,0.275,154,0.656,"trifluridine, carmofur",0.560667306169737,0.18309616062434,FALSE
+"transcriptomics","Pearson.est","topoisomerase inhibitor",0.44261,1.13,0.315,221,0.593,"idarubicin, valrubicin, mitoxantrone, etoposide.phosphate, amonafide, TAS.103, amsacrine, topotecan, dexrazoxane",0.501689446210399,0.226945306635737,FALSE
+"transcriptomics","Pearson.est","tubulin polymerization inhibitor",0.32697,0.831,0.655,569,0.742,"verubulin, KX2.391, docetaxel, mebendazole, vinblastine, taltobulin, flubendazole, BNC105, vindesine, oxibendazole, dolastatin.10, fosbretabulin, epothilone.b, CYT.997",0.183758700008217,0.129596094720973,FALSE
+"transcriptomics","Pearson.est","tyrosine kinase inhibitor",0.40748,1.04,0.391,65,0.659,"sorafenib, regorafenib, hypericin, mubritinib",0.407823242604133,0.18111458540599,FALSE
+"transcriptomics","Pearson.est","VEGFR inhibitor",0.44483,1.13,0.296,184,0.593,"sorafenib, tivozanib, regorafenib, dovitinib, ENMD.2076, linifanib, nintedanib, axitinib, foretinib, OSI.930, pazopanib",0.528708288941061,0.226945306635737,FALSE
+"transcriptomics","Pearson.est","vitamin D receptor agonist",-0.65046,-1.66,0.0295,1262,0.264,"maxacalcitol, calcitriol, paricalcitol",1.53017798402184,0.578396073130169,FALSE
+"proteomics","Pearson.est","EGFR inhibitor",-0.72318,-1.96,0.0125,1243,0.193,"AEE788, tucatinib, lapatinib, poziotinib, TAK.285, CP.724714, PD.153035, neratinib, XL.647, ARRY.334543, rociletinib, OSI.420, AZD8931, icotinib, BIBU.1361, BMS.690514, vandetanib, dacomitinib, PD.168393, erlotinib, gefitinib, afatinib, canertinib, osimertinib, WZ8040, pelitinib",1.90308998699194,0.714442690992226,TRUE
+"proteomics","Pearson.est","Abl kinase inhibitor",-0.26364,-0.683,0.825,1241,1,"metatinib, bosutinib",0.0835460514500749,0,FALSE
+"proteomics","Pearson.est","acetylcholine receptor agonist",0.61565,1.59,0.0524,281,0.636,"xanomeline, nicotine, pilocarpine",1.28066871301627,0.196542884351586,FALSE
+"proteomics","Pearson.est","acetylcholine receptor antagonist",-0.34241,-0.911,0.517,1394,1,"dicycloverine",0.286509456906058,0,FALSE
+"proteomics","Pearson.est","adenosine receptor antagonist",-0.64824,-1.69,0.0209,1379,0.468,"MRS.1220, CGS.15943",1.67985371388895,0.329754146925876,FALSE
+"proteomics","Pearson.est","adrenergic receptor agonist",-0.25882,-0.684,0.827,1070,1,"isoetharine, A61603, oxymetazoline, methyldopa, isoxsuprine",0.0824944904474534,0,FALSE
+"proteomics","Pearson.est","adrenergic receptor antagonist",0.24817,0.65,0.875,89,0.961,"dihydroergocristine, atipamezole, naftidrofuryl",0.0579919469776868,0.0172766123314547,FALSE
+"proteomics","Pearson.est","AKT inhibitor",-0.40623,-1.03,0.384,904,0.785,"uprosertib, MK.2206, ONC201, GSK2110183, AZD5363, triciribine, CCT128930, palomid.529",0.415668775632469,0.105130343254747,FALSE
+"proteomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.40527,-1.08,0.339,1084,0.767,"AZD3463, GW.788388, NVP.TAE684, AP26113, CEP.37440",0.469800301796918,0.115204636051019,FALSE
+"proteomics","Pearson.est","androgen receptor antagonist",-0.22465,-0.592,0.934,807,0.925,"enzalutamide, nilutamide, bicalutamide, flutamide, cyproterone.acetate",0.0296531237699066,0.0338582672609674,FALSE
+"proteomics","Pearson.est","antioxidant",0.39183,1.03,0.405,226,1,"trolox, mesna",0.392544976785331,0,FALSE
+"proteomics","Pearson.est","AP inhibitor",-0.52133,-1.38,0.138,988,0.459,"LCL.161, GDC.0152, birinapant, tanshinone.i, embelin",0.860120913598763,0.338187314462739,FALSE
+"proteomics","Pearson.est","ATPase inhibitor",0.75519,1.93,0.00192,172,0.15,"k.strophanthidin, oligomycin.a, digoxin, NMS.873, evodiamine, digitoxigenin, rabeprazole",2.71669877129645,0.823908740944319,TRUE
+"proteomics","Pearson.est","Aurora kinase inhibitor",0.5415,1.4,0.112,203,0.94,"danusertib, ENMD.2076, barasertib, barasertib.HQPA, AMG900, PHA.680632, CCT137690, SNS.314, AT.9283, MK.5108",0.950781977329818,0.0268721464003014,FALSE
+"proteomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.32274,0.822,0.669,341,0.968,"radezolid, josamycin",0.174573882232177,0.0141246426916063,FALSE
+"proteomics","Pearson.est","bacterial DNA gyrase inhibitor",-0.25046,-0.649,0.883,1206,1,"trovafloxacin, sparfloxacin",0.0540392964224314,0,FALSE
+"proteomics","Pearson.est","BCL inhibitor",0.19468,0.504,0.969,398,0.977,"TW.37, gossypol, venetoclax",0.0136762229492347,0.0101054362812269,FALSE
+"proteomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.33146,-0.849,0.628,1241,1,"metatinib, bosutinib",0.202040356262804,0,FALSE
+"proteomics","Pearson.est","benzodiazepine receptor agonist",-0.28223,-0.753,0.741,405,1,"bentazepam, eprinomectin, ivermectin, piperazine, gamma.aminobutyric.acid, CL.218872, ZK.93423, lorazepam, nefiracetam, zaleplon, indiplon, temazepam, CGS.20625",0.130181792020672,0,FALSE
+"proteomics","Pearson.est","bromodomain inhibitor",0.38558,1.01,0.446,892,0.99,"PFI.1, OTX015, I.BET151, JQ1...., bromosporine, I.BET.762",0.350665141287858,0.00436480540245009,FALSE
+"proteomics","Pearson.est","calcium channel blocker",0.254,0.651,0.863,37,0.984,"carboxyamidotriazole",0.0639892042847904,0.00700490156865849,FALSE
+"proteomics","Pearson.est","CC chemokine receptor antagonist",0.47512,1.28,0.175,219,0.782,"UNBS.5162, SB.225002, ZK811752",0.756961951313706,0.106793246940152,FALSE
+"proteomics","Pearson.est","CDK inhibitor",-0.23141,-0.601,0.9,1038,0.942,"P276.00, dinaciclib, TG.02, BMS.387032, kenpaullone, alvocidib, arcyriaflavin.a, indirubin, CR8..R.",0.0457574905606751,0.0259490972071227,FALSE
+"proteomics","Pearson.est","CHK inhibitor",-0.58219,-1.51,0.105,1005,0.482,"CHIR.124, AZD7762, LY2606368, SCH.900776, LY2603618",0.978810700930062,0.31695296176115,FALSE
+"proteomics","Pearson.est","cyclooxygenase inhibitor",0.19906,0.519,0.971,128,0.993,"sulfasalazine, tepoxalin, phenazone",0.0127807700919951,0.00305075150461883,FALSE
+"proteomics","Pearson.est","cytochrome P450 inhibitor",-0.23454,-0.617,0.906,1026,0.98,"itraconazole, clotrimazole, cobicistat",0.0428718023231869,0.00877392430750515,FALSE
+"proteomics","Pearson.est","DNA alkylating agent",-0.27402,-0.731,0.785,1365,1,"ifosfamide, dacarbazine",0.105130343254747,0,FALSE
+"proteomics","Pearson.est","DNA inhibitor",0.53842,1.39,0.121,306,0.729,"carboplatin, teroxirone, mechlorethamine, tirapazamine, sangivamycin, metronidazole, pibenzimol, chlorambucil, oxaliplatin, carmustine, valrubicin",0.91721462968355,0.137272471682025,FALSE
+"proteomics","Pearson.est","DNA methyltransferase inhibitor",-0.57468,-1.47,0.0808,1290,0.493,"fdcyd, RG108, azacitidine",1.09258863922541,0.30715308072277,FALSE
+"proteomics","Pearson.est","DNA polymerase inhibitor",-0.24801,-0.63,0.895,925,0.994,"famciclovir, adefovir.dipivoxil, menadione, cephalomannine, cidofovir",0.048176964684088,0.00261361560268669,FALSE
+"proteomics","Pearson.est","DNA synthesis inhibitor",0.20875,0.538,0.969,40,1,"artesunate",0.0136762229492347,0,FALSE
+"proteomics","Pearson.est","dopamine receptor antagonist",0.25594,0.651,0.883,218,0.984,"thioproperazine, UH.232...., domperidone",0.0540392964224314,0.00700490156865849,FALSE
+"proteomics","Pearson.est","estrogen receptor agonist",0.35064,0.9,0.557,277,1,"estrone, erteberel, levonorgestrel, estradiol.cypionate",0.254144804826271,0,FALSE
+"proteomics","Pearson.est","estrogen receptor antagonist",0.47827,1.22,0.234,513,0.798,"fulvestrant, tamoxifen, toremifene, danazol",0.630784142589857,0.0979971086492706,FALSE
+"proteomics","Pearson.est","FGFR inhibitor",0.44698,1.15,0.292,317,0.913,"nintedanib, lenvatinib, dovitinib, regorafenib, AZD4547, erdafitinib",0.534617148551582,0.039529222465701,FALSE
+"proteomics","Pearson.est","FLT3 inhibitor",0.27741,0.716,0.814,385,1,"tyrphostin.AG.1296, ENMD.2076, dovitinib, TG.101348, sorafenib, ponatinib",0.0893755951107988,0,FALSE
+"proteomics","Pearson.est","glucocorticoid receptor agonist",0.40297,1.02,0.418,531,1,"beclomethasone.dipropionate, fluticasone.propionate, desonide, triamcinolone, dexamethasone.acetate, halcinonide, ciclesonide, hydrocortisone, clobetasol.propionate, fluocinolone.acetonide, prednisolone, rimexolone, methylprednisolone, halobetasol.propionate",0.378823718224965,0,FALSE
+"proteomics","Pearson.est","glutamate receptor antagonist",-0.54008,-1.41,0.135,1123,0.449,"CPP, MTPG, diazooxonorleucine, SIB.1757, ACDPP, latrepirdine, LY456236",0.869666231504994,0.347753658996677,FALSE
+"proteomics","Pearson.est","glycogen synthase kinase inhibitor",-0.59978,-1.56,0.0687,1180,0.541,"LY2090314, kenpaullone, AZD2858, indirubin, GSK.3.inhibitor.IX",1.16304326294045,0.266802734893431,FALSE
+"proteomics","Pearson.est","growth factor receptor inhibitor",0.60653,1.53,0.0798,83,0.675,"PHA.848125, danusertib",1.09799710864927,0.170696227168975,FALSE
+"proteomics","Pearson.est","HCV inhibitor",-0.56959,-1.46,0.131,1262,0.456,"PSI.7976, embelin, Ro.9187",0.882728704344236,0.341035157335565,FALSE
+"proteomics","Pearson.est","HDAC inhibitor",-0.55487,-1.42,0.12,1125,0.477,"M.344, pyroxamide, vorinostat, givinostat, tacedinaline, mocetinostat, PCI.24781, entinostat, romidepsin, nexturastat.a, panobinostat, SB.939, JNJ.26481585",0.920818753952375,0.321481620959886,FALSE
+"proteomics","Pearson.est","histamine receptor antagonist",-0.51244,-1.32,0.176,1016,0.481,"cimetidine, cyproheptadine, tiotidine, levocetirizine, zolantidine, ICI.162846, terfenadine, ebastine, tecastemizole, chloropyramine",0.75448733218585,0.317854923626168,FALSE
+"proteomics","Pearson.est","HMGCR inhibitor",-0.45228,-1.19,0.25,1088,0.672,"mevastatin, simvastatin",0.602059991327962,0.172630726946175,FALSE
+"proteomics","Pearson.est","HSP inhibitor",-0.52866,-1.35,0.172,1097,0.467,"NVP.AUY922, SNX.5422, XL888, tanespimycin, KW.2478, guanidine, VER.49009, alvespimycin",0.764471553092451,0.330683119433888,FALSE
+"proteomics","Pearson.est","JAK inhibitor",-0.2933,-0.734,0.775,1373,1,"atiprimod, pacritinib, LY2784544",0.11069829749369,0,FALSE
+"proteomics","Pearson.est","KIT inhibitor",0.32207,0.838,0.636,343,0.969,"masitinib, lenvatinib, pazopanib, regorafenib, OSI.930, sorafenib",0.196542884351586,0.0136762229492347,FALSE
+"proteomics","Pearson.est","MDM inhibitor",0.53955,1.39,0.141,229,0.729,"idasanutlin, AMG.232, nutlin.3",0.85078088734462,0.137272471682025,FALSE
+"proteomics","Pearson.est","MEK inhibitor",-0.30621,-0.804,0.697,1428,1,"BIX.02188, nobiletin",0.156767221901991,0,FALSE
+"proteomics","Pearson.est","MET inhibitor",-0.27462,-0.714,0.8,396,1,"PHA.665752, PF.04217903, NVP.BVU972, LY2801653, INC.280, AMG458",0.0969100130080564,0,FALSE
+"proteomics","Pearson.est","microtubule inhibitor",0.37806,0.97,0.475,348,1,"vinblastine, vinflunine, D.64131",0.323306390375133,0,FALSE
+"proteomics","Pearson.est","mTOR inhibitor",0.36001,0.913,0.538,404,1,"AZD2014, MLN0128, voxtalisib, ku.0063794, WYE.125132, XL388, torin.1, PF.04691502, PP242, SB.2343, GSK2126458, NVP.BEZ235, GDC.0980",0.269217724333611,0,FALSE
+"proteomics","Pearson.est","NFkB pathway inhibitor",0.29021,0.773,0.703,4,0.994,"EVP4593",0.153044674980176,0.00261361560268669,FALSE
+"proteomics","Pearson.est","opioid receptor agonist",0.32692,0.864,0.607,338,1,"BW.180C, trimebutine, spiradoline",0.216811308924742,0,FALSE
+"proteomics","Pearson.est","p38 MAPK inhibitor",-0.33949,-0.89,0.537,983,1,"CMPD.1, SB.239063, VX.702, TAK.715",0.270025714300444,0,FALSE
+"proteomics","Pearson.est","PARP inhibitor",-0.22874,-0.608,0.935,984,0.962,"E7449, endo.IWR.1, PJ.34",0.0291883891274822,0.0168249279621871,FALSE
+"proteomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.41356,1.08,0.352,195,0.977,"nintedanib, masitinib, linifanib, axitinib, lenvatinib, pazopanib, dovitinib, regorafenib",0.453457336521869,0.0101054362812269,FALSE
+"proteomics","Pearson.est","phosphatase inhibitor",0.25763,0.659,0.848,182,1,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.0716041477432862,0,FALSE
+"proteomics","Pearson.est","phosphodiesterase inhibitor",-0.61329,-1.58,0.0552,1007,0.615,"papaverine, enoximone, cilostamide, avanafil, anagrelide, zardaverine, GSK256066, YM.976",1.2580609222708,0.211124884224583,FALSE
+"proteomics","Pearson.est","PI3K inhibitor",0.36,0.94,0.507,419,1,"idelalisib, GDC.0941, voxtalisib, ZSTK.474, buparlisib, PF.04691502, SB.2343, GSK2126458, NVP.BEZ235, GDC.0980, PI3K.IN.2",0.294992040666664,0,FALSE
+"proteomics","Pearson.est","PLK inhibitor",0.79112,2.02,0.00195,308,0.129,"volasertib, NMS.1286937, GW.843682X, HMN.214, rigosertib, GSK461364, BI.2536",2.70996538863748,0.889410289700751,TRUE
+"proteomics","Pearson.est","potassium channel blocker",0.25659,0.661,0.877,1078,1,"ML133, ibutilide, mepivacaine, meglitinide, oleoylethanolamide, dofetilide",0.0570004066339595,0,FALSE
+"proteomics","Pearson.est","PPAR receptor agonist",0.30023,0.771,0.715,184,0.967,"clofibrate, fenofibrate",0.145693958198919,0.0145735259169983,FALSE
+"proteomics","Pearson.est","progesterone receptor agonist",0.50904,1.31,0.177,216,0.777,"tanaproget, nomegestrol.acetate, levonorgestrel",0.752026733638193,0.109578981199086,FALSE
+"proteomics","Pearson.est","proteasome inhibitor",-0.65054,-1.7,0.0343,1131,0.661,"ixazomib, ONX.0914, carfilzomib, bortezomib, ixazomib.citrate",1.46470587995723,0.17979854051436,FALSE
+"proteomics","Pearson.est","protein synthesis inhibitor",0.47636,1.23,0.229,276,0.838,"harringtonine, anguidine, cycloheximide, clofoctol, mercaptopurine, bruceantin, clindamycin.phosphate, chloramphenicol.palmitate",0.640164517660112,0.0767559813697235,FALSE
+"proteomics","Pearson.est","protein tyrosine kinase inhibitor",0.32762,0.861,0.611,6,0.99,"mubritinib",0.213958789757446,0.00436480540245009,FALSE
+"proteomics","Pearson.est","RAF inhibitor",-0.40671,-1.04,0.391,1276,0.807,"CEP.32496, vemurafenib, dabrafenib",0.407823242604133,0.0931264652779296,FALSE
+"proteomics","Pearson.est","RET tyrosine kinase inhibitor",-0.42082,-1.1,0.32,1259,0.816,"apatinib, vandetanib",0.494850021680094,0.0883098412461389,FALSE
+"proteomics","Pearson.est","retinoid receptor agonist",0.34224,0.891,0.54,307,1,"adapalene, fenretinide, LE.135, bexarotene",0.267606240177031,0,FALSE
+"proteomics","Pearson.est","ribonucleotide reductase inhibitor",0.21365,0.544,0.962,464,1,"hydroxyurea, pentostatin, triapine, fludarabine.phosphate, LY2334737",0.0168249279621871,0,FALSE
+"proteomics","Pearson.est","serotonin receptor agonist",0.34747,0.9,0.566,314,1,"zolmitriptan, NAN.190",0.247183568811729,0,FALSE
+"proteomics","Pearson.est","serotonin receptor antagonist",0.31056,0.808,0.659,147,0.962,"SB.200646, pirenperone",0.18111458540599,0.0168249279621871,FALSE
+"proteomics","Pearson.est","sodium channel blocker",-0.4194,-1.08,0.329,1341,0.767,"lappaconite, triamterene, mexiletine",0.482804102050026,0.115204636051019,FALSE
+"proteomics","Pearson.est","src inhibitor",-0.31014,-0.804,0.692,1189,1,"PP.2, bosutinib, saracatinib",0.159893905543242,0,FALSE
+"proteomics","Pearson.est","sterol demethylase inhibitor",0.64713,1.63,0.0449,159,0.691,"chlormidazole, sulconazole, posaconazole",1.34775365899668,0.160521952625802,FALSE
+"proteomics","Pearson.est","TGF beta receptor inhibitor",-0.58093,-1.52,0.0869,1183,0.539,"SB.431542, D.4476, repsox, LY2109761",1.06098022355133,0.268411234813261,FALSE
+"proteomics","Pearson.est","thymidylate synthase inhibitor",0.33058,0.854,0.625,34,0.97,"ftorafur",0.204119982655925,0.0132282657337552,FALSE
+"proteomics","Pearson.est","topoisomerase inhibitor",0.42309,1.09,0.32,306,1,"mitoxantrone, idarubicin, etoposide.phosphate, epirubicin, dexrazoxane, doxorubicin, TAS.103, amsacrine, topotecan, voreloxin, valrubicin",0.494850021680094,0,FALSE
+"proteomics","Pearson.est","tubulin polymerization inhibitor",0.5097,1.32,0.158,555,0.835,"verubulin, BNC105, vinblastine, fenbendazole, vindesine, KX2.391, mebendazole, taltobulin, oxibendazole, paclitaxel, docetaxel, ABT.751, epothilone.b, indibulin, nocodazole, dolastatin.10, CYT.997, albendazole, fosbretabulin",0.801342913045577,0.0783135245163979,FALSE
+"proteomics","Pearson.est","tyrosine kinase inhibitor",-0.27733,-0.717,0.787,1249,1,"AV.412, apatinib, CP.724714, rheochrysidin, vandetanib",0.104025267640935,0,FALSE
+"proteomics","Pearson.est","VEGFR inhibitor",0.25686,0.659,0.866,195,1,"nintedanib, SAR131675, linifanib, ENMD.2076, axitinib, lenvatinib, pazopanib, dovitinib, regorafenib",0.0624821079826534,0,FALSE
+"proteomics","Pearson.est","vitamin D receptor agonist",-0.25293,-0.653,0.859,917,1,"ercalcitriol, tacalcitol, paricalcitol, maxacalcitol, calcitriol",0.0660068361687577,0,FALSE
+"metabolomics","Pearson.est","EGFR inhibitor",-0.31798,-0.841,0.637,1024,0.798,"FERb.033, BMS.599626, BIBU.1361, BMS.690514, salvianolic.acid.B, tucatinib, canertinib, PD.168393, neratinib, pelitinib, TAK.285, vandetanib, afatinib, OSI.420, AEE788, brigatinib, osimertinib, PD.153035",0.19586056766465,0.0979971086492706,FALSE
+"metabolomics","Pearson.est","Abl kinase inhibitor",-0.63565,-1.66,0.0583,1039,0.258,"flumatinib, bosutinib, imatinib, GZD824, bafetinib, nilotinib, metatinib, dasatinib, ponatinib",1.23433144524099,0.58838029403677,FALSE
+"metabolomics","Pearson.est","acetylcholine receptor agonist",0.42151,1.1,0.344,240,0.657,"pilocarpine, oxiracetam, nefiracetam",0.46344155742847,0.182434630440219,FALSE
+"metabolomics","Pearson.est","acetylcholine receptor antagonist",0.22648,0.586,0.944,466,0.978,"diphemanil, methscopolamine, iododexetimide",0.025028005701931,0.00966114521239857,FALSE
+"metabolomics","Pearson.est","adenosine receptor antagonist",0.37014,0.943,0.522,275,0.638,"SCH.58261, sulmazole",0.282329496997738,0.195179321278838,FALSE
+"metabolomics","Pearson.est","adrenergic receptor agonist",-0.36429,-0.971,0.455,1141,0.646,"isoetharine, metaraminol, clenbuterol, A61603, epinephrine, terbutaline",0.341988603342888,0.189767482004916,FALSE
+"metabolomics","Pearson.est","adrenergic receptor antagonist",0.368,0.959,0.496,248,0.656,"atenolol......, prazosin, propranolol, oxprenolol, naftidrofuryl",0.304518323509803,0.18309616062434,FALSE
+"metabolomics","Pearson.est","AKT inhibitor",0.21193,0.542,0.961,539,0.983,"AT7867, ONC201, GDC.0068, CCT128930, uprosertib",0.0172766123314547,0.00744648216786438,FALSE
+"metabolomics","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.53809,-1.41,0.135,1247,0.365,"GW.788388, brigatinib, CEP.37440, AP26113",0.869666231504994,0.437707135543525,FALSE
+"metabolomics","Pearson.est","androgen receptor antagonist",0.65925,1.72,0.0255,378,0.209,"bicalutamide, nilutamide, RU.58841, enzalutamide",1.59345981956604,0.679853713888946,TRUE
+"metabolomics","Pearson.est","antioxidant",0.28363,0.73,0.776,1039,0.845,"trolox, mesna, benfotiamine, chlorogenic.acid, taurine, rutin",0.110138278741812,0.0731432910503077,FALSE
+"metabolomics","Pearson.est","AP inhibitor",-0.32039,-0.836,0.642,462,0.784,"birinapant, tanshinone.i, GDC.0152, idronoxil, embelin, LCL.161",0.192464971931147,0.105683937315562,FALSE
+"metabolomics","Pearson.est","ATPase inhibitor",0.42817,1.07,0.368,354,0.651,"rabeprazole, oligomycin.a, evodiamine, digitoxigenin, digitoxin, k.strophanthidin",0.434152181326482,0.186419011431808,FALSE
+"metabolomics","Pearson.est","Aurora kinase inhibitor",0.44069,1.13,0.291,395,0.711,"CCT129202, PHA.680632, barasertib, danusertib, AMG900, GSK1070916, AT.9283, barasertib.HQPA, SNS.314, CCT137690",0.536107011014093,0.148130399270234,FALSE
+"metabolomics","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40441,-1.07,0.367,1301,0.549,"dirithromycin, tedizolid",0.435333935747911,0.260427655549908,FALSE
+"metabolomics","Pearson.est","bacterial DNA gyrase inhibitor",0.33267,0.843,0.604,109,0.729,"norfloxacin, finafloxacin",0.218963061378868,0.137272471682025,FALSE
+"metabolomics","Pearson.est","BCL inhibitor",-0.41158,-1.07,0.373,1187,0.549,"gossypol, HA14.1, navitoclax, oridonin",0.428291168191312,0.260427655549908,FALSE
+"metabolomics","Pearson.est","Bcr.Abl kinase inhibitor",-0.68734,-1.78,0.0186,1039,0.235,"flumatinib, bosutinib, imatinib, GZD824, bafetinib, nilotinib, metatinib, dasatinib, ponatinib",1.73048705578208,0.628932137728264,TRUE
+"metabolomics","Pearson.est","benzodiazepine receptor agonist",0.40418,1.03,0.422,37,0.613,"eprinomectin, bentazepam",0.374687549038326,0.212539525481585,FALSE
+"metabolomics","Pearson.est","bromodomain inhibitor",-0.47947,-1.24,0.23,1045,0.51,"bromosporine, PFI.1, OTX015",0.638272163982407,0.292429823902064,FALSE
+"metabolomics","Pearson.est","calcium channel blocker",-0.25875,-0.669,0.852,1197,0.939,"penfluridol, tetrandrine, SKF.96365",0.0695604052332999,0.0273344077338891,FALSE
+"metabolomics","Pearson.est","CC chemokine receptor antagonist",-0.36725,-0.968,0.483,1113,0.631,"RS.504393, UNBS.5162, navarixin",0.316052869248488,0.199970640755866,FALSE
+"metabolomics","Pearson.est","CDK inhibitor",-0.40931,-1.06,0.344,996,0.545,"arcyriaflavin.a, NU6027, kenpaullone, JNJ.7706621, palbociclib, aminopurvalanol.a, AT.7519, ribociclib, P276.00, abemaciclib",0.46344155742847,0.263603497723358,FALSE
+"metabolomics","Pearson.est","CHK inhibitor",-0.72589,-1.89,0.0146,1225,0.431,"LY2603618, AZD7762, LY2606368, SCH.900776",1.83564714421556,0.365522729839268,FALSE
+"metabolomics","Pearson.est","cyclooxygenase inhibitor",-0.22301,-0.583,0.94,1233,0.978,"tryptanthrin, acetylsalicylsalicylic.acid, suxibuzone, FR.122047, indoprofen",0.0268721464003014,0.00966114521239857,FALSE
+"metabolomics","Pearson.est","cytochrome P450 inhibitor",-0.45847,-1.18,0.273,1356,0.506,"itraconazole",0.563837352959244,0.295849483160201,FALSE
+"metabolomics","Pearson.est","DNA alkylating agent",-0.46038,-1.17,0.29,1423,0.499,"cisplatin, ifosfamide, estramustine",0.537602002101044,0.30189945437661,FALSE
+"metabolomics","Pearson.est","DNA inhibitor",0.4887,1.25,0.224,335,0.599,"carboplatin, mechlorethamine, bendamustine, tirapazamine, teroxirone, oxaliplatin, metronidazole",0.649751981665837,0.222573177610689,FALSE
+"metabolomics","Pearson.est","DNA methyltransferase inhibitor",-0.58817,-1.51,0.0788,1041,0.409,"SGI.1027, RG108, fdcyd, decitabine, azacitidine",1.10347378251044,0.388276691992658,FALSE
+"metabolomics","Pearson.est","DNA polymerase inhibitor",0.4081,1.07,0.362,176,0.651,"famciclovir, cephalomannine, foscarnet",0.441291429466834,0.186419011431808,FALSE
+"metabolomics","Pearson.est","DNA synthesis inhibitor",-0.31726,-0.814,0.67,1268,0.797,"capecitabine, enocitabine, cisplatin",0.173925197299174,0.0985416786038876,FALSE
+"metabolomics","Pearson.est","dopamine receptor antagonist",0.5606,1.46,0.0984,208,0.506,"thioproperazine, clebopride, lurasidone, raclopride, remoxipride, isofloxythepin",1.00700490156866,0.295849483160201,FALSE
+"metabolomics","Pearson.est","estrogen receptor agonist",0.44832,1.17,0.272,213,0.67,"estrone, ethinyl.estradiol, erteberel, levonorgestrel",0.565431095965801,0.173925197299174,FALSE
+"metabolomics","Pearson.est","estrogen receptor antagonist",0.404,1.04,0.373,242,0.648,"raloxifene, clomifene",0.428291168191312,0.188424994129407,FALSE
+"metabolomics","Pearson.est","FGFR inhibitor",-0.41963,-1.11,0.34,1082,0.529,"MK.2461, nintedanib, erdafitinib, lucitanib",0.468521082957745,0.276544327964814,FALSE
+"metabolomics","Pearson.est","FLT3 inhibitor",-0.28822,-0.739,0.785,1321,0.891,"midostaurin, ponatinib, gilteritinib",0.105130343254747,0.0501222959631252,FALSE
+"metabolomics","Pearson.est","glucocorticoid receptor agonist",0.69184,1.79,0.00735,314,0.166,"hydrocortisone, prednisolone, desonide, methylprednisolone, fluticasone.propionate, ciclesonide, halcinonide, triamcinolone.acetonide, dexamethasone.acetate, rimexolone, fluocinolone.acetonide, prednisolone.acetate, triamcinolone, betamethasone, flumethasone.pivalate, difluprednate, piretanide",2.13371266091581,0.779891911959945,TRUE
+"metabolomics","Pearson.est","glutamate receptor antagonist",0.36763,0.939,0.525,151,0.624,"tiletamine, latrepirdine, MTPG",0.279840696594043,0.204815410317576,FALSE
+"metabolomics","Pearson.est","glycogen synthase kinase inhibitor",-0.36358,-0.945,0.486,1003,0.649,"AZD2858, kenpaullone, LY2090314, tideglusib, GSK.3.inhibitor.IX",0.313363730737707,0.187755303199631,FALSE
+"metabolomics","Pearson.est","growth factor receptor inhibitor",0.4,1.03,0.417,377,0.613,"danusertib, GW.441756, PHA.848125, GSK1904529A",0.379863945026242,0.212539525481585,FALSE
+"metabolomics","Pearson.est","HCV inhibitor",0.65894,1.7,0.0229,31,0.198,"PSI.7976, narlaprevir",1.64016451766011,0.703334809738469,TRUE
+"metabolomics","Pearson.est","HDAC inhibitor",-0.57246,-1.45,0.111,1099,0.392,"nexturastat.a, AR.42, PCI.24781, mocetinostat, belinostat, M.344, entinostat, SB.939, dacinostat, resminostat, givinostat, panobinostat, R306465, RG2833, JNJ.26481585",0.954677021213343,0.406713932979543,FALSE
+"metabolomics","Pearson.est","histamine receptor antagonist",0.4019,1.05,0.367,407,0.659,"ranitidine, famotidine, terfenadine, epinastine, zolantidine, nizatidine, ICI.162846, tecastemizole",0.435333935747911,0.18111458540599,FALSE
+"metabolomics","Pearson.est","HMGCR inhibitor",0.45254,1.18,0.27,10,0.692,"fluvastatin",0.568636235841013,0.159893905543242,FALSE
+"metabolomics","Pearson.est","HSP inhibitor",-0.18606,-0.475,0.986,267,0.986,"NMS.E973, tanespimycin, PU.H71, XL888, SNX.2112, alvespimycin, guanidine, KW.2478, ganetespib, VER.49009, NVP.AUY922, BIIB021, SNX.5422",0.0061230850587888,0.0061230850587888,FALSE
+"metabolomics","Pearson.est","JAK inhibitor",0.43162,1.12,0.326,294,0.654,"TG.101348, WHI.P154, CEP.33779, AZD1480, filgotinib, AT.9283",0.486782399932061,0.184422251675733,FALSE
+"metabolomics","Pearson.est","KIT inhibitor",-0.60624,-1.54,0.0784,1066,0.4,"imatinib, vatalanib, sorafenib, sunitinib, telatinib, dasatinib, midostaurin, pazopanib, motesanib, KI.8751",1.10568393731556,0.397940008672038,FALSE
+"metabolomics","Pearson.est","MDM inhibitor",0.8318,2.13,0.00188,145,0.0299,"idasanutlin, CGM097, AMG.232, nutlin.3, RITA",2.72584215073632,1.52432881167557,TRUE
+"metabolomics","Pearson.est","MEK inhibitor",-0.56535,-1.49,0.0833,1131,0.361,"AS.703026, arctigenin, PD.184352, AZD8330, selumetinib, TAK.733, nobiletin, trametinib, BIX.02188, cobimetinib",1.07935499859321,0.442492798094342,FALSE
+"metabolomics","Pearson.est","MET inhibitor",-0.69421,-1.82,0.0179,1143,0.243,"PHA.665752, PF.04217903, LY2801653, INC.280, NVP.BVU972",1.74714696902011,0.614393726401688,TRUE
+"metabolomics","Pearson.est","microtubule inhibitor",0.3641,0.952,0.495,336,0.645,"vinblastine, cabazitaxel, colchicine, triclabendazole",0.305394801066431,0.190440285364732,FALSE
+"metabolomics","Pearson.est","mTOR inhibitor",0.2953,0.763,0.758,300,0.823,"torin.1, AZD8055, SB.2343, ku.0063794, WYE.125132, PP242, voxtalisib, PF.04691502, OSI.027",0.120330794367946,0.0846001647877302,FALSE
+"metabolomics","Pearson.est","NFkB pathway inhibitor",0.38396,0.985,0.452,105,0.66,"parthenolide...., EVP4593, tyloxapol",0.344861565188618,0.180456064458131,FALSE
+"metabolomics","Pearson.est","opioid receptor agonist",0.34303,0.87,0.619,363,0.708,"salvinorin.a, spiradoline, ADL5859",0.208309350979882,0.149966742310231,FALSE
+"metabolomics","Pearson.est","p38 MAPK inhibitor",0.56967,1.45,0.129,245,0.467,"talmapimod, SB.242235, skepinone.l",0.889410289700751,0.330683119433888,FALSE
+"metabolomics","Pearson.est","PARP inhibitor",0.57127,1.44,0.099,267,0.399,"AG.14361, niraparib, olaparib",1.00436480540245,0.399027104313252,FALSE
+"metabolomics","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.51612,-1.34,0.144,1066,0.412,"imatinib, vatalanib, nintedanib, sorafenib, CP.673451, sunitinib, telatinib, dasatinib, pazopanib, SU014813, ponatinib, motesanib, KI.8751",0.84163750790475,0.385102783966865,FALSE
+"metabolomics","Pearson.est","phosphatase inhibitor",-0.25312,-0.648,0.855,1287,0.94,"BVT.948, AS.1949490",0.0680338852718274,0.0268721464003014,FALSE
+"metabolomics","Pearson.est","phosphodiesterase inhibitor",-0.47393,-1.22,0.235,1174,0.491,"GSK256066, zardaverine, trequinsin, YM.976",0.628932137728264,0.308918507877032,FALSE
+"metabolomics","Pearson.est","PI3K inhibitor",0.18031,0.469,0.985,321,0.987,"AZD6482, SB.2343, voxtalisib, PF.04691502, YM.201636, idelalisib",0.00656376950238827,0.00568284733036327,FALSE
+"metabolomics","Pearson.est","PLK inhibitor",0.51495,1.33,0.157,204,0.537,"NMS.1286937, HMN.214",0.804100347590766,0.270025714300444,FALSE
+"metabolomics","Pearson.est","potassium channel blocker",-0.4473,-1.15,0.283,1238,0.51,"mepivacaine, dofetilide",0.54821356447571,0.292429823902064,FALSE
+"metabolomics","Pearson.est","PPAR receptor agonist",0.69707,1.85,0.0139,409,0.137,"clofibrate, fenofibrate, pterostilbene, S26948",1.8569851997459,0.863279432843593,TRUE
+"metabolomics","Pearson.est","progesterone receptor agonist",0.49075,1.25,0.223,384,0.599,"norethindrone, levonorgestrel, norgestrel, tanaproget",0.651695136951839,0.222573177610689,FALSE
+"metabolomics","Pearson.est","proteasome inhibitor",-0.67717,-1.71,0.026,1313,0.232,"bortezomib, ixazomib.citrate, carfilzomib",1.58502665202918,0.6345120151091,TRUE
+"metabolomics","Pearson.est","protein synthesis inhibitor",0.43741,1.12,0.312,305,0.654,"mercaptopurine, bruceantin, anguidine, chloramphenicol.palmitate, clofoctol, cycloheximide, harringtonine, tedizolid.phosphate",0.505845405981557,0.184422251675733,FALSE
+"metabolomics","Pearson.est","protein tyrosine kinase inhibitor",-0.39131,-1.03,0.387,1048,0.57,"BMS.599626, NVP.TAE226, AV.412, tyrphostin.A9, rheochrysidin",0.412289034981089,0.244125144327509,FALSE
+"metabolomics","Pearson.est","RAF inhibitor",-0.72224,-1.85,0.0142,1106,0.286,"CEP.32496, SB.590885, sorafenib, GDC.0879, LGX818, RAF265, AZ.628, TAK.632, dabrafenib, vemurafenib",1.84771165561694,0.543633966870957,FALSE
+"metabolomics","Pearson.est","RET tyrosine kinase inhibitor",-0.66466,-1.71,0.0394,1010,0.232,"apatinib, sorafenib, sunitinib, vandetanib",1.40450377817443,0.6345120151091,TRUE
+"metabolomics","Pearson.est","retinoid receptor agonist",-0.42578,-1.12,0.305,1142,0.535,"fenretinide, LE.135, CD.437, tamibarotene, adarotene",0.515700160653214,0.271646217978772,FALSE
+"metabolomics","Pearson.est","ribonucleotide reductase inhibitor",-0.46168,-1.22,0.219,1084,0.491,"cladribine, LY2334737, fludarabine, triapine, hydroxyurea, clofarabine",0.659555885159882,0.308918507877032,FALSE
+"metabolomics","Pearson.est","serotonin receptor agonist",0.62103,1.59,0.0396,3,0.322,"aripiprazole",1.40230481407449,0.492144128304169,FALSE
+"metabolomics","Pearson.est","serotonin receptor antagonist",0.3806,0.976,0.467,141,0.651,"aripiprazole, lurasidone, pirenperone",0.330683119433888,0.186419011431808,FALSE
+"metabolomics","Pearson.est","sodium channel blocker",-0.19096,-0.498,0.991,949,1,"triamterene, quinidine, oxcarbazepine, lappaconite, benzethonium, mexiletine, mepivacaine",0.00392634551472468,0,FALSE
+"metabolomics","Pearson.est","src inhibitor",-0.56198,-1.49,0.097,1245,0.361,"PP.1, dasatinib, saracatinib, TG.100572",1.01322826573376,0.442492798094342,FALSE
+"metabolomics","Pearson.est","sterol demethylase inhibitor",0.7524,1.92,0,259,0.116,"terconazole, posaconazole, ketoconazole, chlormidazole",Inf,0.935542010773082,TRUE
+"metabolomics","Pearson.est","TGF beta receptor inhibitor",-0.27115,-0.713,0.791,391,0.907,"adaprev, SB.525334, SB.431542, D.4476, LY2109761, repsox",0.101823516502323,0.0423927129399047,FALSE
+"metabolomics","Pearson.est","thymidylate synthase inhibitor",-0.48402,-1.26,0.214,1031,0.506,"raltitrexed, trifluridine, doxifluridine, capecitabine",0.669586226650809,0.295849483160201,FALSE
+"metabolomics","Pearson.est","topoisomerase inhibitor",-0.5355,-1.42,0.102,1070,0.378,"licochalcone.a, SN.38, beta.lapachone, genz.644282, doxorubicin, teniposide, exatecan.mesylate, fleroxacin, rubitecan, daunorubicin, camptothecin, etoposide, irinotecan",0.991399828238082,0.422508200162775,FALSE
+"metabolomics","Pearson.est","tubulin polymerization inhibitor",0.57189,1.44,0.106,483,0.399,"BNC105, epothilone.b, vinorelbine, flubendazole, vinblastine, dolastatin.10, mebendazole, taltobulin, nocodazole, indibulin, KX2.391, oxibendazole, fosbretabulin, verubulin, CYT.997, epothilone.d, ABT.751, vincristine",0.97469413473523,0.399027104313252,FALSE
+"metabolomics","Pearson.est","tyrosine kinase inhibitor",-0.45948,-1.2,0.247,1126,0.496,"sorafenib, NVP.TAE226, AV.412, aminopurvalanol.a, tyrphostin.A9, sunitinib, bafetinib, rheochrysidin, vandetanib, tivantinib, dasatinib, hypericin",0.607303046740334,0.304518323509803,FALSE
+"metabolomics","Pearson.est","VEGFR inhibitor",-0.53789,-1.42,0.11,1081,0.378,"BMS.690514, MK.2461, vatalanib, MGCD.265, nintedanib, sorafenib, sunitinib, vandetanib, RAF265, telatinib, AEE788, pazopanib, SU014813, golvatinib, lucitanib, TG.100572, motesanib, foretinib, KI.8751",0.958607314841775,0.422508200162775,FALSE
+"metabolomics","Pearson.est","vitamin D receptor agonist",-0.51774,-1.34,0.172,1013,0.412,"ercalcitriol, tacalcitol, calcitriol",0.764471553092451,0.385102783966865,FALSE
diff --git a/Examples/Fig5/DMEA/DMEA_venn_diagram.pdf b/Examples/Fig5/DMEA/DMEA_venn_diagram.pdf
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diff --git a/Examples/Fig5/GSEA/GSEA_dot_plot.pdf b/Examples/Fig5/GSEA/GSEA_dot_plot.pdf
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diff --git a/Examples/Fig5/GSEA/GSEA_interactive_network.graph.html b/Examples/Fig5/GSEA/GSEA_interactive_network.graph.html
new file mode 100644
index 0000000..e64413f
--- /dev/null
+++ b/Examples/Fig5/GSEA/GSEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNFQxNDo0MTowNCswMTowMDwveG1wOk1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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
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diff --git a/Examples/Fig5/GSEA/GSEA_mean_results.csv b/Examples/Fig5/GSEA/GSEA_mean_results.csv
new file mode 100644
index 0000000..9c9a628
--- /dev/null
+++ b/Examples/Fig5/GSEA/GSEA_mean_results.csv
@@ -0,0 +1,189 @@
+"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",1.895,0.0636396103067892,0.000289629744604357,"transcriptomics, proteomics",2,0,"",0.041578894589144
+"KEGG_STEROID_BIOSYNTHESIS",1.89,0.15556349186104,0.000461987717657156,"transcriptomics, proteomics",2,0,"",0.041578894589144
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",1.745,0.0212132034355964,0.00121238612149647,"transcriptomics, proteomics",2,0,"",0.0727431672897883
+"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",1.67,0.014142135623731,0.00342297751285385,"transcriptomics, proteomics",2,0,"",0.123227190462739
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",1.64,0.0707106781186547,0.00677055376904717,"transcriptomics, proteomics",2,0,"",0.174099954061213
+"KEGG_SULFUR_METABOLISM",1.605,0.0353553390593273,0.0063332138373181,"transcriptomics, proteomics",2,0,"",0.174099954061213
+"KEGG_O_GLYCAN_BIOSYNTHESIS",1.56,0.183847763108502,0.0122357389880599,"transcriptomics, proteomics",2,0,"",0.244714779761198
+"KEGG_DORSO_VENTRAL_AXIS_FORMATION",1.42,0.212132034355964,0.0342985336504672,"transcriptomics, proteomics",2,0,"",0.440981146934578
+"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",1.405,0.318198051533946,0.0506311492502255,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"KEGG_THYROID_CANCER",1.365,0.318198051533946,0.058491388316597,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",1.34,0.367695526217005,0.0751623370973159,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"KEGG_PENTOSE_PHOSPHATE_PATHWAY",1.33,0.0989949493661166,0.0688290062405358,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",1.325,0.233345237791561,0.0751988455575317,"transcriptomics, proteomics",2,0,"",0.488563619880045
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+"KEGG_NON_SMALL_CELL_LUNG_CANCER",1.0785,0.129400540957138,0.356046125651037,"transcriptomics, proteomics",2,0,"",0.719540934814592
+"KEGG_RENAL_CELL_CARCINOMA",1.075,0.0353553390593274,0.359148173016949,"transcriptomics, proteomics",2,0,"",0.719540934814592
+"KEGG_RIBOFLAVIN_METABOLISM",1.068,0.342239682094289,0.360566335553805,"transcriptomics, proteomics",2,0,"",0.719540934814592
+"KEGG_PANCREATIC_CANCER",1.0585,0.0869741340859454,0.385929479832285,"transcriptomics, proteomics",2,0,"",0.731234803892751
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+"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",1.018,0.087681240867132,0.467205809888853,"transcriptomics, proteomics",2,0,"",0.808625440192245
+"KEGG_ENDOCYTOSIS",1.0165,0.259508188695463,0.381471433836517,"transcriptomics, proteomics",2,0,"",0.730477213729501
+"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",1.0085,0.440527524679219,0.304906011855273,"transcriptomics, proteomics",2,0,"",0.696983176627321
+"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",1,0.395979797464467,0.349878685693999,"transcriptomics, proteomics",2,0,"",0.719540934814592
+"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.998,0.101823376490863,0.494892750858944,"transcriptomics, proteomics",2,0,"",0.827793835551903
+"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.994,0.17819090885901,0.45902012660477,"transcriptomics, proteomics",2,0,"",0.808625440192245
+"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.975,0.403050865276332,0.354719337597814,"transcriptomics, proteomics",2,0,"",0.719540934814592
+"KEGG_FATTY_ACID_METABOLISM",0.9675,0.187383297014435,0.527330933777786,"transcriptomics, proteomics",2,0,"",0.839996177699127
+"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.967,0.216374675043084,0.509575512712316,"transcriptomics, proteomics",2,0,"",0.82816129944154
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.958,0.370523953341751,0.455170326502419,"transcriptomics, proteomics",2,0,"",0.808625440192245
+"KEGG_MELANOGENESIS",0.9565,0.132228968081884,0.568566019627426,"transcriptomics, proteomics",2,0,"",0.876656581794286
+"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.9455,0.053033008588991,0.635794734446359,"transcriptomics, proteomics",2,0,"",0.892269874846721
+"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.942,0.23758787847868,0.576227061477709,"transcriptomics, proteomics",2,0,"",0.876656581794286
+"KEGG_VIRAL_MYOCARDITIS",0.9305,0.253851334445971,0.585304186638296,"transcriptomics, proteomics",2,0,"",0.876656581794286
+"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.9275,0.0615182899632296,0.664511707407244,"transcriptomics, proteomics",2,0,"",0.913069521628274
+"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.9115,0.4362848839921,0.457193277534351,"transcriptomics, proteomics",2,0,"",0.808625440192245
+"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.895,0.140007142674936,0.68938278384523,"transcriptomics, proteomics",2,0,"",0.93299925633189
+"KEGG_GLUTATHIONE_METABOLISM",0.8895,0.130814754519511,0.710303040802014,"transcriptomics, proteomics",2,0,"",0.934679627088488
+"KEGG_JAK_STAT_SIGNALING_PATHWAY",0.8805,0.153442171517481,0.72178037869611,"transcriptomics, proteomics",2,0,"",0.934679627088488
+"KEGG_TASTE_TRANSDUCTION",0.879,0.340825468531916,0.616139892229958,"transcriptomics, proteomics",2,0,"",0.891752231843372
+"KEGG_FOCAL_ADHESION",0.865,0.0466690475583122,0.778415330977841,"transcriptomics, proteomics",2,0,"",0.958789543801597
+"KEGG_PROSTATE_CANCER",0.846,0.103237590053236,0.806269974262101,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.8405,0.0601040764008565,0.826788761897546,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.835,0.124450793488832,0.832427014220701,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_SMALL_CELL_LUNG_CANCER",0.835,0.0579827560572969,0.840582894066333,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.832,0.0692964645562816,0.837876663774707,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_GNRH_SIGNALING_PATHWAY",0.8315,0.252437120883597,0.753287973042953,"transcriptomics, proteomics",2,0,"",0.941609966303691
+"KEGG_BUTANOATE_METABOLISM",0.827,0.014142135623731,0.829364491311233,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.8165,0.0898025612106915,0.865585241060815,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.801,0.10040916292849,0.88025179974882,"transcriptomics, proteomics",2,0,"",0.97778227977331
+"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.7935,0.00636396103067893,0.885436175572497,"transcriptomics, proteomics",2,0,"",0.97778227977331
+"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.782,0.0325269119345812,0.915688308536683,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_CALCIUM_SIGNALING_PATHWAY",0.7745,0.129400540957138,0.911891017671648,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_WNT_SIGNALING_PATHWAY",0.7725,0.0657609306503489,0.902038242898594,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_SPHINGOLIPID_METABOLISM",0.7685,0.0912167747730646,0.917650916328079,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.762,0.421435641587182,0.717437743574537,"transcriptomics, proteomics",2,0,"",0.934679627088488
+"KEGG_INSULIN_SIGNALING_PATHWAY",0.7595,0.269407683632075,0.849872261315658,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_PATHWAYS_IN_CANCER",0.7535,0.101116269709676,0.945521983609552,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_APOPTOSIS",0.745,0.111722871427474,0.940681168755102,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_VIBRIO_CHOLERAE_INFECTION",0.7305,0.451841233178204,0.731122467416446,"transcriptomics, proteomics",2,0,"",0.940014600964001
+"KEGG_GLYCEROLIPID_METABOLISM",0.721,0.288499566724111,0.854061973145639,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.719,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_P53_SIGNALING_PATHWAY",0.693,0.197989898732233,0.934653709254103,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.6865,0.245366053071732,0.94456444662607,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_CHRONIC_MYELOID_LEUKEMIA",0.68,0.0226274169979695,0.985310897788388,"transcriptomics, proteomics",2,0,"",0.99081542794363
+"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.6785,0.161927452891719,0.961161562977455,"transcriptomics, proteomics",2,0,"",0.983006143954216
+"KEGG_LONG_TERM_POTENTIATION",0.6775,0.00212132034355964,0.98450260218051,"transcriptomics, proteomics",2,0,"",0.99081542794363
+"KEGG_OTHER_GLYCAN_DEGRADATION",0.5815,1.68079281888042,0.0539225775101993,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.3465,1.57472680170244,0.155241453668764,"transcriptomics, proteomics",2,0,"",0.55886923320755
+"KEGG_PRIMARY_IMMUNODEFICIENCY",0.346,1.82999234971079,0.0395541742607838,"transcriptomics, proteomics",2,0,"",0.474650091129405
+"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.266,1.39158614537513,0.445713367706894,"transcriptomics, proteomics",2,0,"",0.808625440192245
+"KEGG_TYPE_I_DIABETES_MELLITUS",0.231,1.45522575568191,0.416461648735748,"transcriptomics, proteomics",2,0,"",0.772815430643657
+"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.18,2.05060966544099,0.0207840651537921,"transcriptomics, proteomics",2,0,"",0.34010288433478
+"KEGG_BASAL_CELL_CARCINOMA",0.1605,1.30036937060206,0.590361929751792,"transcriptomics, proteomics",2,0,"",0.876656581794286
+"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.1505,1.00479873606608,0.946045071417951,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_COLORECTAL_CANCER",0.1355,1.09672261762034,0.880002392453183,"transcriptomics, proteomics",2,0,"",0.97778227977331
+"KEGG_PROPANOATE_METABOLISM",0.1325,1.28339880785358,0.627028747122668,"transcriptomics, proteomics",2,0,"",0.891752231843372
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.125,1.61927452891719,0.208168272265051,"transcriptomics, proteomics",2,0,"",0.580027921612858
+"KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.0975,1.48845977439768,0.338030142768267,"transcriptomics, proteomics",2,0,"",0.719540934814592
+"KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.0935,1.38097954365733,0.497776012732322,"transcriptomics, proteomics",2,0,"",0.827793835551903
+"KEGG_BASE_EXCISION_REPAIR",0.082,1.1511698397717,0.857265023387435,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_TYPE_II_DIABETES_MELLITUS",0.064,1.39441457249987,0.501275155973097,"transcriptomics, proteomics",2,0,"",0.827793835551903
+"KEGG_RETINOL_METABOLISM",0.06,1.72534054609518,0.138686810309407,"transcriptomics, proteomics",2,0,"",0.55886923320755
+"KEGG_MISMATCH_REPAIR",0.0599999999999999,1.66877200360025,0.209454527249088,"transcriptomics, proteomics",2,0,"",0.580027921612858
+"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.045,1.81726442764943,0.0954896485332761,"transcriptomics, proteomics",2,0,"",0.509186963684416
+"KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.0435,1.25228610948138,0.742930611205083,"transcriptomics, proteomics",2,0,"",0.941609966303691
+"KEGG_LONG_TERM_DEPRESSION",0.0235,0.968029183444384,0.983071266220555,"transcriptomics, proteomics",2,0,"",0.99081542794363
+"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.00750000000000001,1.18723228561221,0.834182451063396,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.0035,1.2720850993546,0.721292203642806,"transcriptomics, proteomics",2,0,"",0.934679627088488
+"KEGG_SELENOAMINO_ACID_METABOLISM",0.0025,1.04298250225016,0.961132560272309,"transcriptomics, proteomics",2,0,"",0.983006143954216
+"KEGG_HISTIDINE_METABOLISM",0,1.44249783362056,0.465464032013939,"transcriptomics, proteomics",2,0,"",0.808625440192245
+"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.0045,0.878933729014878,0.995617215165771,"transcriptomics, proteomics",2,0,"",0.995617215165771
+"KEGG_DILATED_CARDIOMYOPATHY",-0.0205,1.26077139085561,0.7106332998997,"transcriptomics, proteomics",2,0,"",0.934679627088488
+"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.025,1.30673333163274,0.639460076973484,"transcriptomics, proteomics",2,0,"",0.892269874846721
+"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.035,1.68998520703585,0.193070851987586,"transcriptomics, proteomics",2,0,"",0.580027921612858
+"KEGG_ALZHEIMERS_DISEASE",-0.039,1.05076067684321,0.936874243335078,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_MAPK_SIGNALING_PATHWAY",-0.059,1.16389776183306,0.827671052153154,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_PHENYLALANINE_METABOLISM",-0.06,1.73948268171891,0.148236352806265,"transcriptomics, proteomics",2,0,"",0.55886923320755
+"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.0755,1.34986684528512,0.581919599579247,"transcriptomics, proteomics",2,0,"",0.876656581794286
+"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.081,1.27844906038528,0.68830907169884,"transcriptomics, proteomics",2,0,"",0.93299925633189
+"KEGG_GLIOMA",-0.1015,1.23248711960815,0.75110990515617,"transcriptomics, proteomics",2,0,"",0.941609966303691
+"KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.105,1.70412734265958,0.188746314557271,"transcriptomics, proteomics",2,0,"",0.580027921612858
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.12,1.90918830920368,0.076117502409686,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"KEGG_NITROGEN_METABOLISM",-0.126,1.47643895911751,0.443060612986735,"transcriptomics, proteomics",2,0,"",0.808625440192245
+"KEGG_OOCYTE_MEIOSIS",-0.137,0.98712106653642,0.939111980022951,"transcriptomics, proteomics",2,0,"",0.97866731525995
+"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.148,1.21905209076561,0.702678853474599,"transcriptomics, proteomics",2,0,"",0.934679627088488
+"KEGG_PROTEASOME",-0.1565,1.34845263172275,0.513193430697479,"transcriptomics, proteomics",2,0,"",0.82816129944154
+"KEGG_PYRUVATE_METABOLISM",-0.174,1.1511698397717,0.764671332425092,"transcriptomics, proteomics",2,0,"",0.949247171286321
+"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.1755,1.50543033714616,0.380440796464836,"transcriptomics, proteomics",2,0,"",0.730477213729501
+"KEGG_TRYPTOPHAN_METABOLISM",-0.181,1.32794653506834,0.571029200005094,"transcriptomics, proteomics",2,0,"",0.876656581794286
+"KEGG_OLFACTORY_TRANSDUCTION",-0.202,1.2982480502585,0.584456329114831,"transcriptomics, proteomics",2,0,"",0.876656581794286
+"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.202,1.26996377901104,0.553108101178551,"transcriptomics, proteomics",2,0,"",0.873328580808238
+"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.211,1.66735779003788,0.20821238198023,"transcriptomics, proteomics",2,0,"",0.580027921612858
+"KEGG_LYSINE_DEGRADATION",-0.2135,1.21127391617256,0.662940099043489,"transcriptomics, proteomics",2,0,"",0.913069521628274
+"KEGG_HOMOLOGOUS_RECOMBINATION",-0.2215,1.27067088579223,0.629180741356157,"transcriptomics, proteomics",2,0,"",0.891752231843372
+"KEGG_LINOLEIC_ACID_METABOLISM",-0.235,1.97282791951047,0.0810077524681304,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.282,1.68008571209924,0.226246554998265,"transcriptomics, proteomics",2,0,"",0.617036059086176
+"KEGG_OXIDATIVE_PHOSPHORYLATION",-0.3435,1.42340595052852,0.361818002370916,"transcriptomics, proteomics",2,0,"",0.719540934814592
+"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.352,1.56694862710939,0.287002914058151,"transcriptomics, proteomics",2,0,"",0.688806993739563
+"KEGG_CELL_CYCLE",-0.368,1.24733636201307,0.379991896654085,"transcriptomics, proteomics",2,0,"",0.730477213729501
+"KEGG_ABC_TRANSPORTERS",-0.501,1.66735779003788,0.151596030142548,"transcriptomics, proteomics",2,0,"",0.55886923320755
+"KEGG_PRION_DISEASES",-0.5565,1.80100097168214,0.0733110251462656,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.653,1.59381868479448,0.0988641838634014,"transcriptomics, proteomics",2,1,"transcriptomics",0.509186963684416
+"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.6775,2.04000306372319,0.0270572557103867,"transcriptomics, proteomics",2,0,"",0.374638925220738
+"KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.679,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_PYRIMIDINE_METABOLISM",-0.7645,0.23546655813512,0.860202570783159,"transcriptomics, proteomics",2,0,"",0.973783396193417
+"KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.806,0.401636651713959,0.627885566032803,"transcriptomics, proteomics",2,0,"",0.891752231843372
+"KEGG_ALLOGRAFT_REJECTION",-0.807,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_HUNTINGTONS_DISEASE",-0.814,0.291327993848858,0.739114047366216,"transcriptomics, proteomics",2,0,"",0.941609966303691
+"KEGG_BETA_ALANINE_METABOLISM",-0.835,0.00424264068711929,0.783011460771304,"transcriptomics, proteomics",2,0,"",0.958789543801597
+"KEGG_GAP_JUNCTION",-0.866,0.373352380466497,0.598593325122088,"transcriptomics, proteomics",2,0,"",0.876656581794286
+"KEGG_PURINE_METABOLISM",-0.884,0.17819090885901,0.599048664226095,"transcriptomics, proteomics",2,0,"",0.876656581794286
+"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.9615,0.252437120883597,0.515300364096958,"transcriptomics, proteomics",2,0,"",0.82816129944154
+"KEGG_REGULATION_OF_AUTOPHAGY",-0.988,0.398808224589213,0.47673446521645,"transcriptomics, proteomics",2,0,"",0.8172590832282
+"KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.989,0.340825468531916,0.492504604487226,"transcriptomics, proteomics",2,0,"",0.827793835551903
+"KEGG_PARKINSONS_DISEASE",-1.007,0.527501658765164,0.344234056941909,"transcriptomics, proteomics",2,0,"",0.719540934814592
+"KEGG_PROTEIN_EXPORT",-1.06,0.0424264068711929,0.390838753342179,"transcriptomics, proteomics",2,0,"",0.732822662516586
+"KEGG_DNA_REPLICATION",-1.075,0.657609306503489,0.127061226224373,"transcriptomics, proteomics",2,0,"",0.55886923320755
+"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-1.0935,0.461740728114815,0.273580409275154,"transcriptomics, proteomics",2,0,"",0.679941153934616
+"KEGG_MELANOMA",-1.107,0.230516810666815,0.314238519866347,"transcriptomics, proteomics",2,0,"",0.698307821925215
+"KEGG_SPLICEOSOME",-1.1435,0.23546655813512,0.25472078183329,"transcriptomics, proteomics",2,0,"",0.654996296142745
+"KEGG_ASTHMA",-1.2,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_RNA_POLYMERASE",-1.215,0.00707106781186548,0.179784464973633,"transcriptomics, proteomics",2,0,"",0.580027921612858
+"KEGG_BASAL_TRANSCRIPTION_FACTORS",-1.225,0.0494974746830584,0.159226874568896,"transcriptomics, proteomics",2,0,"",0.559561738554814
+"KEGG_RNA_DEGRADATION",-1.335,0.106066017177982,0.0678705513843905,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"acyl carnitines",-1.38,NA,NA,"metabolomics",1,0,"",NA
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-1.4235,0.645588491223318,0.0515831087853856,"transcriptomics, proteomics",2,1,"transcriptomics",0.488563619880045
+"KEGG_RIBOSOME",-1.425,0.190918830920368,0.0802871241396461,"transcriptomics, proteomics",2,0,"",0.488563619880045
+"alpha amino acids",-1.44,NA,NA,"metabolomics",1,0,"",NA
+"KEGG_AUTOIMMUNE_THYROID_DISEASE",-1.46,NA,NA,"transcriptomics",1,0,"",NA
+"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-1.55,0.551543289325507,0.0158758045857219,"transcriptomics, proteomics",2,1,"transcriptomics",0.285764482542995
+"KEGG_ONE_CARBON_POOL_BY_FOLATE",-1.565,0.00707106781186548,0.0240143366970624,"transcriptomics, proteomics",2,0,"",0.360215050455935
+"KEGG_LIMONENE_AND_PINENE_DEGRADATION",-1.68,0.282842712474619,0.00983411446231775,"transcriptomics, proteomics",2,0,"",0.221267575402149
+"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-1.795,0.0353553390593274,0.00190190546248448,"transcriptomics, proteomics",2,1,"transcriptomics",0.0855857458118017
+"KEGG_NON_HOMOLOGOUS_END_JOINING",-2.015,0.106066017177982,NA,"transcriptomics, proteomics",2,2,"transcriptomics, proteomics",NA
diff --git a/Examples/Fig5/GSEA/GSEA_results.csv b/Examples/Fig5/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..c324572
--- /dev/null
+++ b/Examples/Fig5/GSEA/GSEA_results.csv
@@ -0,0 +1,370 @@
+"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"transcriptomics","Log2FC","KEGG_ABC_TRANSPORTERS",0.23561,0.678,0.94,7191,1,"ABCA12, ABCB8, ABCB9, ABCA13, ABCD1, ABCC3, ABCA1, ABCA2, ABCB11, ABCC10, ABCD4, ABCA4, ABCC5, ABCA5, TAP2, ABCC11, ABCG1, ABCB6, ABCG2",0.0268721464003014,0,FALSE
+"transcriptomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36169,1.04,0.374,5916,0.766,"PIK3R2, IKBKB, MAPK3, RPS6KB2, PML, RARA, PIK3CA, JUP, STAT5B, STAT3, BRAF, RELA, TCF7L1, RUNX1, BAD, PIM1, PIK3R3, CCNA1, STAT5A, MAPK1, PIK3R5, PIK3CB, CEBPA",0.42712839779952,0.115771230367396,FALSE
+"transcriptomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.36058,1.03,0.394,3562,0.786,"NECTIN1, CTNND1, CDH1, ERBB2, BAIAP2, NECTIN4, PTPN1, RAC2, MAPK3, INSR, PTPN6, SNAI2, MET, IGF1R, EP300, EGFR, PTPRF, TCF7L1, PTPRB, SRC",0.404503778174426,0.104577453960592,FALSE
+"transcriptomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.27558,0.798,0.819,5975,1,"TRADD, RXRA, CPT1B, PPARA, IKBKB, ACSL1, RXRB, CPT1C, ADIPOR1, IRS2, STAT3, PRKAA1, RELA, ACSL3, PRKAG2, PRKAB2, ACSL5, ACSL6, SLC2A1, MAPK10, IRS1, NFKBIA",0.0867160982395816,0,FALSE
+"transcriptomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.44972,1.32,0.102,3496,0.756,"GLUL, AGXT, GLS2, ASL, ABAT, ASS1, GPT, NIT2, IL4I1",0.991399828238082,0.121478204498793,FALSE
+"transcriptomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.37286,1.08,0.322,5894,0.74,"PIK3R2, SCNN1A, MAPK3, INSR, PIK3CA, SFN, SCNN1G, IRS2, NEDD4L, PIK3R3, SCNN1B, HSD11B2, MAPK1, PIK3R5, IRS1, PIK3CB",0.492144128304169,0.130768280269024,FALSE
+"transcriptomics","Log2FC","KEGG_ALLOGRAFT_REJECTION",-0.23407,-0.807,0.727,16990,1,"PRF1, IL5",0.138465589140962,0,FALSE
+"transcriptomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.40981,1.18,0.214,3971,0.738,"PLA2G12A, PLA2G6, PLA2G4B, PLA2G10, PLA2G4E, ACOX1, PLA2G2C",0.669586226650809,0.131943638176958,FALSE
+"transcriptomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",0.24418,0.704,0.903,6624,0.99,"NDUFV1, CAPN1, CACNA1D, GRIN1, ATP2A3, CALML3, COX5B, LRP1, ATP5F1E, NDUFB7, MAPK3, CDK5, FADD, NDUFS8, EIF2AK3, NDUFA3, NDUFV2, COX6C, UQCR10, GRIN2A, APH1A, COX6B2, GRIN2D, CHP1, PPP3CA, SDHD, ADAM10, BAD, UQCR11, GNAQ, NDUFB4, NDUFAB1, APOE, CALML6, UQCRB, BACE2, NDUFA6, UQCRHL, ITPR3, NDUFA5, UQCRC1, NDUFB5, BID, MAPK1, CACNA1F, UQCRFS1, UQCRC2, PLCB3, COX6A1, GSK3B, NDUFA2, SNCA, APP, ERN1, CAPN2, ATP5PD, GRIN2C, NOS1, CHP2",0.0443122496864942,0.00436480540245009,FALSE
+"transcriptomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.55987,-1.94,0.00943,17343,0.184,"IARS2, MARS2, FARS2, FARSB, WARS2, RARS2, PSTK, YARS2",2.02548830726267,0.735182176990464,TRUE
+"transcriptomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51252,1.51,0.0419,5085,0.448,"HK2, MPI, GMPPA, NANP, GCK, PGM1, GMPPB, NPL, NAGK, GALT, CYB5R1, NANS, FPGT, HK1, GALE, UXS1, CYB5R3, HEXB, GNPDA1, AMDHD2, PGM2",1.3777859770337,0.348721986001856,FALSE
+"transcriptomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28452,0.823,0.733,4515,1,"CAT, CCS, CASP1, MAPK13, GRIN1, GRIN2A, GPX1, GRIN2D, CHP1, MAPK11, PPP3CA, BAD, MAP3K5",0.134896025358872,0,FALSE
+"transcriptomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26803,0.783,0.821,4719,1,"RFXANK, IFI30, TAPBP, CALR, CD74, CTSS, LGMN, CTSB, HSPA1B, B2M, CIITA, PDIA3, PSME1, CD4",0.0856568428805592,0,FALSE
+"transcriptomics","Log2FC","KEGG_APOPTOSIS",0.28433,0.824,0.742,6624,1,"TRADD, IL1RAP, CAPN1, PIK3R2, ENDOD1, IKBKB, PIK3CA, MYD88, FADD, TNFSF10, CASP10, RELA, CHP1, PPP3CA, IRAK4, BAD, ENDOG, PIK3R3, NGF, PRKACA, IL1A, BID, CSF2RB, BAX, PIK3R5, PIK3CB, IL1R1, NFKBIA, PRKAR1B, DFFA, CAPN2, BCL2L1, CHP2",0.129596094720973,0,FALSE
+"transcriptomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.38876,1.11,0.279,2694,0.73,"PLA2G12A, CYP4F3, CYP2E1, PTGES, PLA2G6, GGT7, PLA2G4B, LTC4S, PTGES2, EPHX2, CYP2J2, CYP4A22, PTGS1, PLA2G10, PLA2G4E, ALOX12B",0.554395796726402,0.136677139879544,FALSE
+"transcriptomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31866,0.908,0.617,5717,0.975,"GLUL, PYCR3, CKMT1A, CKMT1B, SAT2, NOS3, GLS2, ASL, ASS1, OAT, GATM, P4HA2, NAGS, PRODH, P4HA1, MAOA, AZIN2, ALDH4A1, GAMT",0.209714835966758,0.0109953843014632,FALSE
+"transcriptomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.3651,1.07,0.358,3482,0.748,"ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, JUP, DSP, ITGA3, CACNB2, DAG1, DSG2, ITGA2B, DSC2, TCF7L1, PKP2",0.446116973356126,0.126098402135539,FALSE
+"transcriptomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.50501,-1.77,0.0103,14596,0.157,"UGDH, MIOX, ALDH3A2, UGT2A1, ALDH1B1, ALDH7A1, ALDH9A1",1.98716277529483,0.804100347590766,TRUE
+"transcriptomics","Log2FC","KEGG_ASTHMA",-0.34369,-1.2,0.212,17122,0.518,"IL13, EPX, IL5",0.673664139071249,0.285670240254767,FALSE
+"transcriptomics","Log2FC","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.42092,-1.46,0.0825,16806,0.317,"IFNA21, PRF1, IFNA13, IL5, CTLA4",1.08354605145007,0.498940737782249,FALSE
+"transcriptomics","Log2FC","KEGG_AXON_GUIDANCE",0.44776,1.31,0.108,5666,0.756,"EPHA1, PAK6, PLXNB2, EPHB3, PLXNB1, PLXNA3, SEMA4A, EFNA1, FES, SEMA3E, EFNA4, SEMA4B, RAC2, LIMK2, SEMA7A, EFNA3, SRGAP3, MAPK3, NTN4, RHOD, UNC5B, NTN1, PLXNB3, CDK5, EPHB4, MET, PLXNA2, EPHB6, SEMA3B, ABLIM3, NCK2, EPHB2, SEMA4F, SRGAP1, UNC5A, ABLIM2, EFNB3, EFNB1, ABLIM1, SEMA5B, CHP1, PPP3CA, PAK2, SEMA4C, SEMA4D, NGEF, SEMA3C, LIMK1, NCK1, SEMA5A, RASA1, RND1, ROBO3, RAC1, PAK1, PAK4, MAPK1, NFATC1",0.96657624451305,0.121478204498793,FALSE
+"transcriptomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",0.3741,1.08,0.314,4115,0.74,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, WNT4, DVL3, BMP2, WNT10A, GLI3, TCF7L1, FZD4, DVL2, WNT11",0.503070351926785,0.130768280269024,FALSE
+"transcriptomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36638,-1.26,0.167,18395,0.512,"TBPL1, TAF9B, TBP, GTF2H2, TAF9, TAF1L",0.777283528852417,0.290730039024169,FALSE
+"transcriptomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",0.30931,0.896,0.629,912,0.957,"SMUG1, POLD4, POLB",0.201349354554731,0.0190880622231565,FALSE
+"transcriptomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.24897,-0.832,0.686,17472,1,"ALDH1B1, ALDH7A1, SMS, ALDH9A1",0.163675884293248,0,FALSE
+"transcriptomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.30636,0.879,0.673,3986,0.973,"ACOT4, TECR, ACAA1, ELOVL6, ACOX1, SCD5",0.171984935776023,0.0118871597316481,FALSE
+"transcriptomics","Log2FC","KEGG_BLADDER_CANCER",0.38783,1.13,0.275,4516,0.72,"CDH1, ERBB2, MMP9, TYMP, VEGFB, MAPK3, EGFR, E2F1, DAPK1, THBS1, FGFR3, BRAF, PGF, VEGFA, DAPK2",0.560667306169737,0.142667503568732,FALSE
+"transcriptomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.28276,0.817,0.752,2472,1,"ABAT, HMGCL, BDH1, HMGCS1, ACADS, EHHADH",0.123782159408358,0,FALSE
+"transcriptomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39615,1.16,0.232,6959,0.709,"VAV1, BLNK, PIK3R2, PLCG2, DAPP1, RAC2, VAV3, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, IFITM1, CD72, CD79A, RELA, CD19, CHP1, PPP3CA, LYN, PIK3R3, RAC1, MAPK1, NFATC1, PIK3R5, PIK3AP1, PIK3CB, NFKBIA, GSK3B, FOS, SYK, NFATC4, GRB2, CHP2, INPP5D, BCL10, CD22",0.6345120151091,0.149353764816933,FALSE
+"transcriptomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.29926,0.866,0.698,4406,0.976,"DRD5, PTAFR, BDKRB2, ERBB2, P2RX4, PLCG2, GNA15, CACNA1D, ERBB3, GRIN1, PLCD1, ATP2A3, CALML3, NOS3, CAMK2G, ADORA2B, ADORA2A, CACNA1I, ADCY4, BDKRB1, RYR1, PTK2B, EGFR, ATP2B4, SLC8A2, GRIN2A, PLCG1, SPHK2, PHKG1, ADRB2, GRIN2D, CHP1, P2RX6, PPP3CA, EDNRA, TNNC1, GNAS, GNAQ, P2RX2, LTB4R2, HTR7",0.156144577376839,0.0105501823333082,FALSE
+"transcriptomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27818,0.796,0.785,6162,1,"TNNI3, CACNA1D, CACNG1, COX5B, CACNB3, CACNG4, CACNB2, COX6C, UQCR10, COX6B2, TNNT2, TNNC1, SLC9A1, UQCR11, UQCRB, UQCRHL, UQCRC1, CACNA1F, UQCRFS1, UQCRC2, COX6A1",0.105130343254747,0,FALSE
+"transcriptomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.37321,1.08,0.333,3535,0.74,"CDH3, NECTIN1, CDH1, CLDN8, ITGB2, CLDN9, CLDN7, CLDN4, F11R, ITGB8, CDH5, SDC1, ICOSLG, SDC4, CLDN18, ICAM3, CD6, GLG1, CLDN11, CD40, SELL, PTPRF, CLDN23, CD276, CLDN3",0.47755576649368,0.130768280269024,FALSE
+"transcriptomics","Log2FC","KEGG_CELL_CYCLE",-0.36349,-1.25,0.124,15880,0.493,"ORC1, MCM4, PTTG2, CCNA2, ORC6, SMAD4, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, MCM3, ANAPC10, CDK6, CDC20, CDK1, SMC1A, CCNH, CCNB3, CDKN2C, CDC25A, TGFB1, ORC4, CCNB1, MCM6, PRKDC, TTK, CDC14A, CDKN2B, E2F2, BUB3, ORC2, CDC7, PTTG1, YWHAQ, HDAC2, SMC3, E2F5, ORC3, CDKN2A, E2F3, SMAD2, ANAPC13",0.906578314837765,0.30715308072277,FALSE
+"transcriptomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.31904,0.929,0.578,4742,0.946,"CCR3, PRKCD, CCL22, STAT2, GRK7, VAV1, PIK3R2, FOXO3, GRK2, CX3CL1, RAC2, VAV3, CCL17, JAK3, CXCL10, IKBKB, MAPK3, CCL28, CCR2, ARRB1, VAV2, CCR7, ADCY5, PIK3CA, ADCY4, CXCL11, CXCL16, CCL5, PTK2B, STAT5B, RAP1A, CXCL9, CXCR2, STAT3, BRAF, ADCY6, RELA, TIAM1, PXN, GNB2, TIAM2, CCL26, CCL19, CXCL3, PRKCZ, CXCR6, WASL, LYN, PIK3R3, STAT1, CCR1",0.238072161579471,0.0241088635982073,FALSE
+"transcriptomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.24297,0.696,0.913,6797,0.991,"CBLC, BCR, PIK3R2, IKBKB, MAPK3, PIK3CA, STAT5B, E2F1, CBLB, BRAF, CDKN1B, RELA, MECOM, RUNX1, BAD, PIK3R3, TGFB3, CRKL, STAT5A, TGFBR2, MAPK1, PIK3R5, PIK3CB, NFKBIA, CDKN1A, BCL2L1, GRB2, CTBP1, CCND1",0.039529222465701,0.00392634551472468,FALSE
+"transcriptomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.41491,1.19,0.181,4027,0.722,"BHLHE41, NR1D1, CSNK1E, BHLHE40, PER3",0.742321425130815,0.141462802430361,FALSE
+"transcriptomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29489,0.861,0.697,7287,0.98,"PC, IDH2, ACO2, IDH3B, SDHD, OGDHL, MDH1, MDH2, OGDH, IDH3G, IDH1, SUCLG2, SDHA",0.156767221901991,0.00877392430750515,FALSE
+"transcriptomics","Log2FC","KEGG_COLORECTAL_CANCER",-0.17873,-0.64,1,14592,1,"KRAS, RAF1, LEF1, CASP9, BIRC5, AKT2, MAPK9, BCL2, MSH6, CASP3, MSH3, RHOA, APPL1, APC2, AKT3, SMAD4, PIK3R1, PIK3CG, MSH2, APC, TGFB1, TCF7, MAPK8, AXIN2, SMAD2",0,0,FALSE
+"transcriptomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.26321,0.774,0.821,6969,1,"BDKRB2, F3, BDKRB1, VWF, FGA, FGG, CFB, PROC, C3, PLAU, CD59, SERPINA5, C2, PLAT, SERPINA1, C9, C1R, CFI, F8, CD55, C4A, SERPINF2, F12, FGB",0.0856568428805592,0,FALSE
+"transcriptomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.22246,-0.783,0.813,15262,1,"BHMT, ADI1, MTR, CDO1, GOT2, SRM, LDHB, MAT2A, AMD1, SMS, MTAP, TRDMT1",0.0899094544059319,0,FALSE
+"transcriptomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33412,0.968,0.513,5572,0.862,"CCR3, IFNL3, IFNL1, CSF1R, CCL22, TNFSF13, IFNL2, IL1RAP, CRLF2, TNFRSF21, PDGFA, IL9R, BMP7, CX3CL1, TNFRSF18, CCL17, IL4R, VEGFB, CXCL10, LTBR, CCL28, CCR2, IFNLR1, EPOR, IFNB1, PDGFB, BMP2, CCR7, FLT3LG, MET, CXCL11, CXCL16, CCL5, TNFRSF25, EGFR, CTF1, ACVR1B, IL18, CD40, IL12B, CXCL9, TNFSF10, CXCR2, TNFRSF14, CLCF1, IL7R, EPO, CCL26, IL20RB, IL6R, IL6, NGFR, CCL19, CXCL3, IL20RA, TNFSF18, CXCR6, VEGFA, CSF2, TNFRSF12A, IL15RA, CCR1, LTB, IL12A, IL1R2, PRLR, TGFB3, CSF1, GH2, OSMR, INHBB, IL1A, VEGFC, EDAR, IFNGR1, TGFBR2, CXCL6, IL17RA, CSF2RB",0.289882634888184,0.0644927341752872,FALSE
+"transcriptomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.36654,1.06,0.35,3908,0.769,"CASP1, MAVS, RIPK3, IRF3, CXCL10, IKBKB, IFNB1, CCL5, DDX58, IL18, PYCARD, RELA, IKBKE, IL6",0.455931955649724,0.114073660198569,FALSE
+"transcriptomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",0.30112,0.871,0.675,4386,0.973,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ADCY5, ADCY4, ITGA3, CACNB2, DAG1, ITGA2B, ADCY6, TNNT2, TNNC1, GNAS, ITGA2",0.170696227168975,0.0118871597316481,FALSE
+"transcriptomics","Log2FC","KEGG_DNA_REPLICATION",-0.44719,-1.54,0.0288,15778,0.294,"DNA2, RFC2, MCM4, RFC5, MCM3, RNASEH1, PRIM1, MCM6, RNASEH2B, PRIM2, POLE3, RFC1, RPA2, POLA1",1.54060751224077,0.531652669587843,FALSE
+"transcriptomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.4409,1.27,0.123,5751,0.75,"ETV7, ETS2, MAPK3, ETV6, EGFR, NOTCH3, PIWIL2, NOTCH1, MAPK1, SPIRE1, SPIRE2",0.910094888560602,0.1249387366083,FALSE
+"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47037,1.37,0.0703,3662,0.683,"ADH7, ALDH3B2, GSTK1, CYP2E1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, FMO4, MGST2, CYP2D6, UGT2B17, MGST3",1.15304467498018,0.165579296318467,FALSE
+"transcriptomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.40437,1.16,0.245,3623,0.709,"XDH, TYMP, NAT1, UCKL1, CES2, UPP1, TK1, CDA, UGT2B17, TPMT, GUSB, ITPA",0.610833915635468,0.149353764816933,FALSE
+"transcriptomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.39479,1.14,0.244,4629,0.715,"CHAD, LAMA3, ITGB6, LAMB3, ITGB8, SDC1, SDC4, CD47, TNC, LAMC2, GP6, ITGB4, CD44, AGRN, THBS3, VWF, ITGA3, DAG1, THBS1, ITGA2B, COL1A1, LAMA5, LAMB1, ITGA2, COL5A1, HSPG2",0.612610173661271,0.145693958198919,FALSE
+"transcriptomics","Log2FC","KEGG_ENDOCYTOSIS",0.41396,1.2,0.183,5701,0.724,"EPN3, CHMP4B, CBLC, PSD4, CSF1R, ITCH, TRAF6, RAB11FIP4, CHMP2B, GRK7, FGFR2, RAB22A, PLD1, ARFGAP1, CHMP2A, GRK2, RAB5B, ARAP1, ERBB3, TFRC, ACAP1, EHD2, PLD2, SMURF1, VPS37C, ARRB1, CHMP5, PRKCI, CHMP3, RAB11FIP1, MET, MVB12A, SH3GLB2, IGF1R, CHMP6, VPS28, ARAP2, PARD6B, EGFR, EPN1, ARFGAP3, VPS37B, FGFR3, LDLRAP1, CXCR2, ARFGAP2, CBLB, EPS15, AP2M1, ADRB2, SRC, HSPA1B, CHMP4C, RAB11FIP5, AGAP1, ACAP2, PRKCZ, AP2A1, NEDD4L, ARAP3, PIP5K1C, STAMBP, CHMP1B, LDLR, ASAP2, HSPA2, IQSEC1, DNM2, RAB11B, RAB31, ARF6, RAB5C, VPS25, STAM2",0.737548910269571,0.140261433802853,FALSE
+"transcriptomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.26466,0.773,0.846,3392,1,"CDH1, ERBB2, PIK3R2, FOXO3, MAPK3, PIK3CA, EGFR, BRAF, TCF7L1",0.0726296369609765,0,FALSE
+"transcriptomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.38362,1.12,0.278,6354,0.711,"MAPK13, PLCG2, F11R, ATP6V1C2, ATP6V0D2, ATP6V1B1, ATP6V1F, IKBKB, MET, CCL5, EGFR, ATP6AP1, CXCR2, PLCG1, RELA, SRC, MAPK11, NOD1, ADAM10, TCIRG1, LYN, ATP6V1G1, ATP6V0A4, RAC1, PAK1, MAPK10, ATP6V1C1, NFKBIA, TJP1, ATP6V1E1, IGSF5",0.555955204081924,0.148130399270234,FALSE
+"transcriptomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.39525,1.16,0.229,5894,0.709,"GAB1, PAK6, CBLC, ERBB2, PIK3R2, PLCG2, ERBB3, CAMK2G, MAPK3, RPS6KB2, PIK3CA, NCK2, EGFR, STAT5B, BTC, CBLB, BRAF, PLCG1, CDKN1B, SRC, TGFA, PAK2, AREG, BAD, PIK3R3, NCK1, CRKL, STAT5A, PAK1, PAK4, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB",0.640164517660112,0.149353764816933,FALSE
+"transcriptomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.38786,1.12,0.276,3971,0.711,"PLA2G12A, PLD1, PLA2G6, PLA2G4B, PLD2, LPCAT2, PLA2G10, PLA2G4E, PLPP3, LPCAT4, PLA2G2C",0.559090917934782,0.148130399270234,FALSE
+"transcriptomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.38078,1.1,0.3,3627,0.737,"ADH7, ACAA1, CPT1B, GCDH, CYP4A22, ACSL1, CPT2, CPT1C, ACADS, EHHADH, ACOX1, ACSL3",0.522878745280338,0.132532512140949,FALSE
+"transcriptomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.33886,0.976,0.483,2596,0.858,"PRKCD, PLA2G12A, VAV1, MAPK13, PIK3R2, PLCG2, RAC2, VAV3, PLA2G6, PLA2G4B, MAPK3, VAV2, PIK3CA, PLA2G10, PLA2G4E",0.316052869248488,0.0665127121512946,FALSE
+"transcriptomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.40295,1.17,0.217,5894,0.738,"PRKCD, VAV1, PLD1, PIK3R2, PLCG2, RAC2, VAV3, LIMK2, PLA2G6, PLA2G4B, PLA2G4F, PLD2, MAPK3, RPS6KB2, VAV2, MARCKS, GSN, PIK3CA, PLA2G4E, PLCG1, PLPP3, SPHK2, WASL, LYN, PIK3R3, PIP5K1C, SPHK1, LIMK1, CRKL, SCIN, ASAP2, MYO10, DNM2, RAC1, PAK1, ARF6, MAPK1, PIK3R5, PIK3CB",0.66354026615147,0.131943638176958,FALSE
+"transcriptomics","Log2FC","KEGG_FOCAL_ADHESION",0.30588,0.898,0.614,6359,0.962,"PAK6, CHAD, ERBB2, LAMA3, VAV1, ITGB6, PDGFA, PIK3R2, LAMB3, ITGB8, RAC2, VAV3, VEGFB, TNC, LAMC2, ITGB4, MAPK3, PPP1CA, VAV2, PDGFB, PIK3CA, PPP1CB, MET, IGF1R, THBS3, VWF, PDGFD, ITGA3, EGFR, RAP1A, THBS1, ITGA2B, BRAF, CAV2, PXN, COL1A1, SRC, CAV1, MYL9, ARHGAP35, PAK2, LAMA5, BAD, PGF, LAMB1, ITGA2, COL5A1, VEGFA, RASGRF1, PIK3R3, PIP5K1C, CRKL, MYL7, ARHGAP5, VEGFC, RAC1, PAK1, BCAR1, PAK4, MAPK1, MAPK10, PIK3R5, PIK3CB, PTEN, COL1A2, ITGA5, TLN2, GSK3B, COL6A1, DIAPH1, ITGA4, CAPN2",0.211831628858832,0.0168249279621871,FALSE
+"transcriptomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.42522,1.24,0.159,5764,0.729,"ALPP, QDPR, SPR, FPGS",0.798602875679548,0.137272471682025,FALSE
+"transcriptomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5816,1.68,0.0112,3752,0.315,"ALDOC, PFKFB2, HK2, MPI, GMPPA, FBP1, GMPPB, PFKL, FBP2, MTMR1, FPGT, HK1, PFKFB4, ALDOA",1.95078197732982,0.501689446210399,FALSE
+"transcriptomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.52612,1.53,0.0321,3636,0.436,"HK2, GCK, GAA, PGM1, PFKL, B4GALT1, GALT, GANC, HK1, B4GALT2, GLB1, GALE",1.49349496759513,0.360513510731414,FALSE
+"transcriptomics","Log2FC","KEGG_GAP_JUNCTION",-0.17017,-0.602,0.99,15556,0.985,"ADRB1, TUBB3, ITPR2, MAP2K5, ADCY7, PRKX, TUBA1B, TUBB, GNAI1, ITPR1, TUBAL3, PRKACB, CDK1, PLCB4, PDGFRA, TUBA1A, NRAS, TUBB4A, TUBB2B, TUBB2A",0.00436480540245009,0.00656376950238827,FALSE
+"transcriptomics","Log2FC","KEGG_GLIOMA",0.26293,0.77,0.86,3686,1,"PDGFA, PIK3R2, PLCG2, CALML3, CAMK2G, MAPK3, PDGFB, PIK3CA, IGF1R, EGFR, E2F1, BRAF, PLCG1, TGFA",0.0655015487564323,0,FALSE
+"transcriptomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.33643,0.982,0.462,4600,0.85,"GSTK1, GGT7, GSTT2, GSTO2, GSS, IDH2, GSTZ1, GSTA3, OPLAH, MGST2, GGT6, GPX1, MGST3, ANPEP, G6PD, GPX3",0.335358024443874,0.0705810742857073,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.17981,0.517,0.998,5968,0.997,"DGKA, LIPG, DGAT1, MGLL, TKFC, PLPP3, CEL, DGKH, AGPAT2, PNPLA3, DGKI, AWAT2, MBOAT1, DGKE",0.000869458712628891,0.00130484168834428,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.36747,1.08,0.348,5053,0.74,"PISD, CDS1, PLA2G12A, CHKB, DGKA, PLD1, PLA2G6, PLA2G4B, PLD2, PCYT2, CHKA, LPCAT2, ETNK2, CDS2, PLA2G10, PLA2G4E, PLPP3, MBOAT7, LPCAT4, PLA2G2C, DGKH, AGPAT2, PGS1, LPCAT3, LYPLA2, ACHE, PCYT1A, DGKI",0.458420756053419,0.130768280269024,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31093,0.903,0.626,6983,0.968,"AGXT, GCAT, AOC2, GATM, SARDH, SHMT1, MAOA, AMT, GAMT, CTH, SDS, GNMT, AOC3, ALAS2, SRR",0.20342566678957,0.0141246426916063,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.4334,1.25,0.141,1880,0.742,"LDHC, ADH7, ACSS2, ALDH3B2, ALDOC, HK2, ALDH1A3, GCK, ALDH3B1, FBP1, PGM1, GALM, PFKL",0.85078088734462,0.129596094720973,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.43624,1.27,0.142,4160,0.75,"B4GALT7, CHPF, CHST12, XYLT2, CHST14, XYLT1, CHPF2, CHST11, CHST15",0.847711655616944,0.1249387366083,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.45434,1.32,0.113,3529,0.756,"B4GALT7, EXT1, HS3ST1, XYLT2, HS6ST1, NDST1, HS6ST2, XYLT1",0.94692155651658,0.121478204498793,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66703,1.94,0.00221,3600,0.275,"B3GNT7, CHST6, B4GALT4, B4GALT1, B3GNT2, CHST4, ST3GAL1, B4GALT2",2.65560772631489,0.560667306169737,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.5591,1.63,0.0157,4196,0.327,"HGSNAT, NAGLU, HPSE, HYAL4, IDS, GALNS, HYAL2, GUSB, GLB1, HEXB",1.80410034759077,0.485452247339714,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.42593,1.23,0.161,6306,0.72,"ST6GALNAC5, B3GALT4, SLC33A1, ST3GAL1, GLB1, HEXB, ST6GALNAC6, ST6GALNAC4, HEXA, ST8SIA1",0.79317412396815,0.142667503568732,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.58271,1.69,0.0158,4276,0.354,"FUT2, FUT1, NAGA, B3GALNT1, ST3GAL1, GBGT1, A4GALT, HEXB, B3GALT5",1.80134291304558,0.450996737974212,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.59777,1.73,0.011,3600,0.325,"B3GNT3, ABO, FUT3, FUT2, B4GALT4, B3GNT5, B3GNT4, B4GALT1, FUT1, B3GNT2, ST3GAL4, B4GALT2",1.95860731484178,0.488116639021126,FALSE
+"transcriptomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50004,1.46,0.0477,3611,0.549,"PIGT, PIGU, GPAA1, PIGZ, PIGV, PIGQ, PIGL, PIGX, PIGS",1.32148162095989,0.260427655549908,FALSE
+"transcriptomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.50461,-1.78,0.0202,16224,0.189,"HYI, MTHFD2L, MTHFD2, ACO1, CS, MTHFD1L, HAO2",1.69464863055338,0.723538195826756,TRUE
+"transcriptomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.34964,1.01,0.424,2596,0.816,"PRKCD, PLA2G12A, MAPK13, PLD1, CACNA1D, PLA2G6, CALML3, PLA2G4B, MAP3K4, PLD2, CAMK2G, MAPK3, MAP3K1, ADCY5, CGA, ADCY4, MMP14, PTK2B, PLA2G10, EGFR, PLA2G4E",0.372634143407267,0.0883098412461389,FALSE
+"transcriptomics","Log2FC","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.20626,-0.679,0.865,3907,1,"IL6, IL1A, KLRC1, KIR2DL1, IL1B, KIR2DL3, KIR3DL2, CD86, FAS, CD80, IFNG, CD28, TNF, KLRD1, GZMB, FASLG, IL2, PRF1",0.0629838925351858,0,FALSE
+"transcriptomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36379,1.07,0.331,2621,0.748,"WNT3A, WNT9A, WNT7B, BMP7, WNT7A, WNT4, BMP2, CSNK1E, WNT10A, CSNK1A1, GLI3",0.480172006224281,0.126098402135539,FALSE
+"transcriptomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.38485,1.12,0.283,6109,0.711,"CSF1R, IL9R, IL4R, TFRC, EPOR, FLT3LG, CD44, ITGA3, CD9, ITGA2B, CD19, IL7R, EPO, IL6R, IL6, ANPEP, CD59, ITGA2, CSF2, CD4, IL1R2, CSF1, IL1A, IL1R1, CD1D, CD55, ITGA5",0.54821356447571,0.148130399270234,FALSE
+"transcriptomics","Log2FC","KEGG_HISTIDINE_METABOLISM",0.35152,1.02,0.419,1584,0.807,"ALDH3B2, HEMK1, HAL, ALDH1A3, ALDH3B1",0.377785977033705,0.0931264652779296,FALSE
+"transcriptomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",0.23381,0.677,0.93,764,0.995,"POLD4, SEM1",0.0315170514460649,0.00217691925427455,FALSE
+"transcriptomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.17121,-0.608,0.99,16664,1,"ITPR1, NDUFS4, BBC3, AP2S1, SOD1, COX6B1, COX7A2, DCTN4, AP2A2, PLCB4, ATP5F1C, NDUFA9, VDAC2, POLR2E, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, HDAC2, HIP1, TBPL1, TBP, UCP1, ATP5F1A, POLR2D, BDNF, NDUFS5, TFAM, GRIN2B",0.00436480540245009,0,FALSE
+"transcriptomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30969,0.899,0.622,4437,0.969,"TNNI3, ITGB6, ITGB8, CACNA1D, CACNG1, CACNB3, CACNG4, ITGB4, ITGA3, CACNB2, DAG1, ITGA2B, PRKAA1, ACE, TNNT2, IL6, TNNC1, ITGA2, PRKAG2",0.206209615309181,0.0136762229492347,FALSE
+"transcriptomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30094,0.872,0.682,6116,0.98,"PLCG2, INPP4B, PLCD1, INPP4A, ALDH6A1, PIK3CA, PIP4K2C, PLCG1, PIK3C2G, PIK3C2B, INPP5K, IMPA2, PIP5K1C, INPPL1, INPP5J, ISYNA1, PIK3CB, PTEN, PLCB3, IPMK",0.166215625343521,0.00877392430750515,FALSE
+"transcriptomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.32542,0.95,0.513,6911,0.894,"CBLC, PPP1R3D, HK2, PTPN1, PIK3R2, GYS1, CALML3, SOCS1, MKNK1, GCK, IKBKB, MAPK3, RPS6KB2, FBP1, INSR, PPP1CA, SH2B2, PIK3CA, PPP1CB, PRKCI, TSC1, FBP2, IRS2, PTPRF, CBLB, BRAF, PRKAA1, PHKG1, HK1, FOXO1, PRKCZ, BAD, PRKAG2, INPP5K, EXOC7, PIK3R3, FASN, PYGL, CALML6, CRKL, PRKAB2, PRKACA, RHEB, PPP1R3B, MAPK1, FLOT2, MAPK10, PIK3R5, IRS1, PIK3CB, PRKAR1B, GSK3B, PHKG2, TRIP10, GRB2, INPP5D, PYGB, PRKAG1, TSC2, RPTOR",0.289882634888184,0.0486624812040823,FALSE
+"transcriptomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.3125,0.906,0.613,3908,0.97,"TNFSF13, ICOSLG, LTBR, CCL28, CD40, PIGR, IL6",0.212539525481585,0.0132282657337552,FALSE
+"transcriptomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.33678,0.989,0.466,5894,0.849,"IFNL3, IFNL1, CBLC, STAT2, IFNL2, CRLF2, PIK3R2, IL9R, IRF9, JAK3, IL4R, SOCS1, CISH, IFNLR1, EPOR, PTPN6, IFNB1, PIK3CA, TYK2, EP300, STAT6, CTF1, STAT5B, IL12B, CBLB, STAT3, CLCF1, IL7R, EPO, IL20RB, IL6R, IL6, PIAS3, IL20RA, PIM1, CSF2, PIK3R3, SPRY1, IL15RA, STAT1, IL12A, PRLR, GH2, STAT5A, OSMR, IFNGR1, JAK1, CSF2RB, STAM2, PIK3R5, PIK3CB",0.33161408331,0.0710923097560473,FALSE
+"transcriptomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.42556,1.23,0.151,6358,0.72,"TRAF6, ITGB2, NCF4, MAPK13, MAPK3, PTPN6, MYD88, IL12B, TAB1, RELA, MAPK11, C3, TLR2, IRAK4, STAT1, IL12A, TGFB3, IL1A, IFNGR1, JAK1, TAB2, MAPK1, NFKBIA, FOS, ITGA4",0.821023052706831,0.142667503568732,FALSE
+"transcriptomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.41873,1.2,0.198,3793,0.724,"CTNND1, CLDN8, ITGB2, MMP9, CLDN9, VAV1, NCF4, CLDN7, MAPK13, PIK3R2, PLCG2, CLDN4, F11R, CDH5, RAC2, VAV3, VAV2, CLDN18, PIK3CA, RASSF5, PTK2B, RAP1A, CLDN11, RAPGEF3, PLCG1, SIPA1, PXN, CLDN23, CLDN3, MYL9, MAPK11, ARHGAP35",0.703334809738469,0.140261433802853,FALSE
+"transcriptomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.42081,-1.48,0.0769,15341,0.33,"ALDH3A2, HADHA, YOD1, ALDH1B1, ALDH7A1, ALDH9A1",1.11407366019857,0.481486060122112,FALSE
+"transcriptomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",0.40266,1.16,0.259,2596,0.709,"PLA2G12A, CYP2E1, PLA2G6, PLA2G4B, CYP2J2, PLA2G10, PLA2G4E",0.586700235918748,0.149353764816933,FALSE
+"transcriptomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",0.24312,0.708,0.903,6599,1,"PLA2G12A, GNAO1, PLA2G6, PLA2G4B, MAPK3, IGF1R, RYR1, PLA2G10, PLA2G4E, BRAF, PLA2G2C, GNAS, GNAQ, LYN, ITPR3, MAPK1, PLCB3, PPP2R1A, GUCY1A1, NOS1, PLA2G2F, GUCY1B1, GNA12",0.0443122496864942,0,FALSE
+"transcriptomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.23447,0.676,0.938,5774,0.988,"GRIN1, CALML3, CAMK2G, MAPK3, PPP1CA, PPP1CB, EP300, RAP1A, RAPGEF3, GRIN2A, BRAF, GRIN2D, CHP1, PPP3CA, GNAQ, RPS6KA2, CALML6, ITPR3, PRKACA, MAPK1, RPS6KA1",0.0277971616209356,0.00524305541237188,FALSE
+"transcriptomics","Log2FC","KEGG_LYSINE_DEGRADATION",0.22598,0.643,0.957,2472,0.999,"BBOX1, KMT5B, KMT5C, GCDH, AASDH, EHHADH",0.0190880622231565,0.000434511774017692,FALSE
+"transcriptomics","Log2FC","KEGG_LYSOSOME",0.52683,1.54,0.0398,5277,0.452,"CTSH, GM2A, CTSA, CTSV, HGSNAT, SLC11A1, NAGLU, GGA2, CTSD, ARSA, ATP6V0D2, LIPA, DNASE2, ABCB9, SUMF1, GAA, MANBA, NPC1, NAGA, ACP5, PSAP, IDS, GNPTG, NPC2, AP1M2, GALNS, CTSS, LAPTM4A, NAPSA, AP1B1, AP3M2, GGA1, LGMN, NEU1, TPP1, ATP6AP1, PSAPL1, ASAH1, LAMP3, CD68, CTSB, LAMP1, CLN5, GUSB, GLB1, GGA3, AP3S2, LAMP2, FUCA1, NAGPA, SCARB2, CTSE, HEXB, PPT1, AP1S1, TCIRG1, MAN2B1, CD63, SLC11A2, MFSD8, ABCA2, CTSZ, SORT1, AP1S3, ATP6V0A4, ENTPD4, GBA",1.40011692792631,0.344861565188618,FALSE
+"transcriptomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",0.26798,0.764,0.837,5856,0.998,"NTF4, PLA2G12A, TRAF6, FGF11, FGFR2, MAPK13, PDGFA, CACNA1D, RAC2, CACNG1, PLA2G6, PLA2G4B, MAP3K4, MKNK1, DUSP9, CACNB3, HSPB1, CACNG4, IKBKB, MAPK3, ARRB1, MAP4K1, MAP3K1, PDGFB, CACNA1I, FGF1, DUSP3, MAPK8IP2, MAX, NTRK2, PLA2G10, EGFR, CACNB2, PLA2G4E, MAP3K11, MAPKAPK3, RAP1A, JUND, ECSIT, MAP3K6, TAB1, LAMTOR3, FGFR3, MAP3K13, TAOK3, BRAF, DUSP10, RELA, STK3, DUSP14, CHP1, HSPA1B, MAPK11, PPP3CA, PAK2, PLA2G2C, MECOM, MAP3K8, GADD45B, RASGRF1, FGF12, MAP4K2, MAP3K5, RPS6KA2, IL1R2, RASA1, RPS6KA4, MAPKAPK2, NF1, STK4, TGFB3, CRKL, PPM1A, HSPA2, NGF, PRKACA, IL1A, RAC1, PAK1, MAP4K3, TGFBR2, RRAS, TAB2, MAPK1, DUSP8, MAP2K7, NLK, GADD45A, RPS6KA1, MAPK10, MAPK8IP3, CACNA1F",0.07727454200674,0.000869458712628891,FALSE
+"transcriptomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26478,0.765,0.837,1432,1,"HES1, GCK",0.07727454200674,0,FALSE
+"transcriptomics","Log2FC","KEGG_MELANOGENESIS",0.36219,1.05,0.368,6175,0.756,"WNT3A, WNT9A, WNT7B, FZD10, WNT7A, GNAO1, CALML3, WNT4, DVL3, CAMK2G, MAPK3, ADCY5, WNT10A, ADCY4, EP300, ADCY6, TCF7L1, FZD4, CREB3L4, DVL2, WNT11, GNAS, GNAQ, CALML6, CREB3L3, MITF, PRKACA, ASIP, CREB3L2, MAPK1, EDN1, CREB3L1, WNT5A, PLCB3, FZD6, GSK3B",0.434152181326482,0.121478204498793,FALSE
+"transcriptomics","Log2FC","KEGG_MELANOMA",-0.26432,-0.944,0.509,16564,0.82,"PIK3R1, PIK3CG, FGF20, CDK6, FGF21, FGF2, PDGFRA, E2F2, NRAS, IGF1, FGF9, FGF4, CDKN2A, FGF5, FGFR1, E2F3, FGF19, FGF3",0.293282217663241,0.0861861476162833,FALSE
+"transcriptomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.45636,1.33,0.1,3662,0.798,"ADH7, ALDH3B2, GSTK1, DHDH, CYP2E1, CYP1B1, ALDH1A3, GSTT2, GSTO2, ALDH3B1, GSTZ1, GSTA3, MGST2, UGT2B17, MGST3",1,0.0979971086492706,FALSE
+"transcriptomics","Log2FC","KEGG_MISMATCH_REPAIR",-0.32549,-1.12,0.269,15319,0.652,"MSH6, RFC3, MSH3, RFC2, RFC5, EXO1, MSH2, RFC1, RPA2",0.570247719997592,0.18575240426808,FALSE
+"transcriptomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.35512,1.01,0.429,6050,0.816,"PIK3R2, VEGFB, MAPK3, RPS6KB2, PIK3CA, TSC1, CAB39, RICTOR, BRAF, PRKAA1, PGF, VEGFA, PIK3R3, HIF1A, RPS6KA2, DDIT4, VEGFC, RHEB, MAPK1, RPS6KA1, PIK3R5, PIK3CB, ULK1",0.367542707815276,0.0883098412461389,FALSE
+"transcriptomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.2602,0.755,0.852,6624,0.987,"ITGB2, VAV1, PIK3R2, PLCG2, RAC2, VAV3, RAET1L, MAPK3, PTPN6, VAV2, IFNB1, PIK3CA, SH3BP2, PTK2B, TNFSF10, BRAF, PLCG1, CHP1, PPP3CA, LCK, CSF2, PIK3R3, ULBP2, RAC1, IFNGR1, PAK1, BID, MAPK1, NFATC1, PIK3R5, PIK3CB, SYK, NFATC4, HCST, GRB2, CHP2",0.0695604052332999,0.00568284733036327,FALSE
+"transcriptomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.21335,0.617,0.972,5100,0.992,"DRD5, P2RY2, VIPR2, PTAFR, BDKRB2, P2RY6, P2RX4, LPAR2, VIPR1, S1PR4, THRB, GRIN1, NPBWR1, ADORA1, ADORA2B, ADORA2A, GIPR, S1PR2, GALR3, CGA, BDKRB1, GHSR, GABRP, F2RL3, GRIN2A, OPRL1, CHRNB4, MLNR, S1PR5, ADRB2, GRIN2D, P2RX6, EDNRA, F2RL1, MC3R, P2RX2, LTB4R2, HTR7, CHRNB1, ADRA2A, GRIN3B, GRM4, LTB4R, PRLR, ADRA2B, GH2",0.0123337350737254,0.00348832784582135,FALSE
+"transcriptomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.33316,0.971,0.508,5975,0.863,"GAB1, NTF4, PRKCD, TRAF6, MAPK13, PIK3R2, PLCG2, FOXO3, CALML3, ARHGDIB, IKBKB, CAMK2G, MAPK3, MAP3K1, SH2B2, PIK3CA, NTRK2, RAP1A, IRS2, TP73, BRAF, PLCG1, YWHAB, RELA, MAPK11, NGFR, IRAK4, BAD, YWHAZ, MAP3K5, PIK3R3, YWHAH, RPS6KA2, SORT1, CALML6, RPS6KA4, MAPKAPK2, CRKL, NGF, RAC1, BAX, MAPK1, MAP2K7, RPS6KA1, MAPK10, PIK3R5, IRS1, PIK3CB, NFKBIA",0.294136287716081,0.0639892042847904,FALSE
+"transcriptomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.264,0.756,0.833,4274,0.994,"QPRT, NMRK1, NADSYN1, NADK, NT5C1B",0.0793549985932124,0.00261361560268669,FALSE
+"transcriptomics","Log2FC","KEGG_NITROGEN_METABOLISM",0.31831,0.918,0.592,2116,0.957,"GLUL, HAL, GLS2, CA9",0.22767829327708,0.0190880622231565,FALSE
+"transcriptomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34339,0.991,0.45,4477,0.853,"CASP1, TRAF6, MAPK13, TAB3, IKBKB, MAPK3, TRIP6, CCL5, IL18, PYCARD, TAB1, RELA, CARD6, MAPK11, IL6, NOD1, NOD2, PSTPIP1, NLRP1",0.346787486224656,0.069050968832477,FALSE
+"transcriptomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.55072,-1.94,0,17605,0.184,"RAD50, PRKDC, NHEJ1, XRCC5",Inf,0.735182176990464,TRUE
+"transcriptomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.34338,0.987,0.455,3686,0.845,"ERBB2, RXRA, PIK3R2, PLCG2, FOXO3, MAPK3, PIK3CA, RASSF5, RXRB, EGFR, E2F1, BRAF, PLCG1, TGFA",0.341988603342888,0.0731432910503077,FALSE
+"transcriptomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.39588,1.15,0.236,5482,0.711,"DTX4, HES1, DVL3, DTX3L, JAG1, DTX2, RFNG, EP300, DLL1, LFNG, NOTCH3, APH1A, MFNG, DVL2, JAG2, NUMB, NOTCH1, KAT2A, HES5",0.627087997029893,0.148130399270234,FALSE
+"transcriptomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.30853,-1.09,0.275,15978,0.584,"RFC2, XPC, RFC5, GTF2H1, XPA, GTF2H3, ERCC3, CUL4A, ERCC8, CCNH, ERCC1, POLE3, RFC1, RPA2, GTF2H2",0.560667306169737,0.233587152887601,FALSE
+"transcriptomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39086,1.13,0.257,3600,0.72,"MAN1B1, RPN2, ALG12, ALG3, DPM1, MOGS, MGAT4A, MGAT1, B4GALT1, MGAT5B, STT3A, ALG2, B4GALT2",0.590066876668705,0.142667503568732,FALSE
+"transcriptomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",0.24959,0.716,0.904,7709,1,"OR4C6, OR10H2, OR2J3, OR11H4, OR8A1, OR2A12, OR2D3, GUCY2D, CALML3, OR8B8, CAMK2G, CLCA2, OR1G1, OR2A7, OR13H1, OR1I1, OR13D1, CNGB1, OR1F1, OR8G5, OR8G1, OR10A3, OR1M1, OR6Q1, OR1K1, OR5P2, OR10H1, OR10A4, OR4D2, OR2A2, CNGA4, OR52B4, CALML6, OR2D2, OR2B2, OR1J1, OR6B1, PRKACA, OR2A14, GUCA1B, OR52K1, OR9A2, OR10A6, OR4L1, OR10AD1, OR2S2, OR10S1, OR10A2, OR2A5, OR10K2, OR10A5, OR8S1, OR4X2, OR5P3, ADCY3, OR6C70, OR8D2, OR8B4, OR2L2, CAMK2D, OR10G3, PRKG2, OR4K1, PRKACG, GRK3, OR8D1, OR52I1, OR6A2",0.0438315695246367,0,FALSE
+"transcriptomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44426,-1.56,0.0566,14974,0.314,"DHFR, SHMT2, MTHFS, MTR, MTHFD2L, GART, MTHFD2, MTHFD1L, TYMS, ATIC",1.24718356881173,0.503070351926785,FALSE
+"transcriptomics","Log2FC","KEGG_OOCYTE_MEIOSIS",-0.25168,-0.835,0.685,15742,1,"ITPR2, PPP2R5D, PPP3CC, ADCY7, PPP2R5C, PRKX, RPS6KA3, PTTG2, PPP2CB, PPP2R1B, SKP1, MAD2L2, BUB1, CDC25C, CDC23, CCNB2, ITPR1, ANAPC10, FBXO5, CDC20, PRKACB, PPP3R1, CDK1, SMC1A, CALM2, CCNB1, FBXO43, CPEB1, AR, PTTG1, YWHAQ, SGO1, SMC3, IGF1, PPP1CC, ANAPC13",0.164309428507574,0,FALSE
+"transcriptomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",0.61199,1.77,0.01,5940,0.328,"MANBA, NEU1, ENGASE, MAN2B2, MAN2C1, GLB1, FUCA1, HEXB, MAN2B1, GBA, HEXA, AGA",2,0.484126156288321,FALSE
+"transcriptomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",0.23049,0.663,0.951,6376,0.992,"NDUFV1, LHPP, ATP6V1C2, COX5B, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP5F1E, NDUFB7, NDUFS8, NDUFA3, NDUFV2, ATP6AP1, COX6C, UQCR10, COX6B2, SDHD, UQCR11, TCIRG1, NDUFB4, NDUFAB1, ATP6V1G1, UQCRB, ATP6V0A4, NDUFA6, UQCRHL, NDUFA5, UQCRC1, NDUFB5, COX15, ATP5MG, UQCRFS1, ATP6V1C1, UQCRC2, COX6A1, ATP6V1E1, NDUFA2, COX17, ATP5PD",0.0218194830625861,0.00348832784582135,FALSE
+"transcriptomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.49419,1.43,0.0603,4056,0.601,"GALNT12, GALNT3, GALNT7, GALNT6, B4GALT5, GCNT1, ST6GALNAC1, GCNT3, C1GALT1, GALNT15, ST3GAL1, GALNT11, GALNT9, B3GNT6",1.21968268785985,0.22112552799726,FALSE
+"transcriptomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.1914,0.553,0.991,5981,0.999,"TP53AIP1, CCNG2, CD82, SERPINB5, SFN, THBS1, TP73, ATR, PERP, SHISA5, EI24, GADD45B, ZMAT3, CCNE1, SIAH1, PIDD1, BID, IGFBP3, BAX, CHEK2, GADD45A, PTEN",0.00392634551472468,0.000434511774017692,FALSE
+"transcriptomics","Log2FC","KEGG_PANCREATIC_CANCER",0.34675,0.997,0.453,5894,0.846,"ERBB2, PLD1, PIK3R2, RALB, RAC2, VEGFB, IKBKB, MAPK3, RALGDS, PIK3CA, EGFR, E2F1, RALBP1, STAT3, BRAF, RELA, TGFA, BAD, PGF, VEGFA, PIK3R3, STAT1, TGFB3, RALA, VEGFC, RAC1, JAK1, TGFBR2, MAPK1, MAPK10, PIK3R5, PIK3CB",0.343901797987168,0.0726296369609765,FALSE
+"transcriptomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.31788,0.923,0.587,8542,0.953,"PANK2, PPCS, ENPP1, COASY, UPB1, PPCDC, BCAT2, DPYD, VNN2",0.231361898752386,0.0209070993616736,FALSE
+"transcriptomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.18037,-0.634,0.965,17631,1,"UBE2J2, ATP5F1C, NDUFA9, VDAC2, LRRK2, ATP5MC2, VDAC1, COX4I1, NDUFS3, SLC25A6, UCHL1, ATP5F1A, SLC18A2, PARK7, NDUFS5",0.0154726866562074,0,FALSE
+"transcriptomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.30571,-1.1,0.25,18248,0.625,"YWHAQ, TUBA1A, NCL, ROCK2, TUBB4A, ARHGEF2, TUBB2B, TUBB2A",0.602059991327962,0.204119982655925,FALSE
+"transcriptomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.2849,0.825,0.772,5981,1,"WNT3A, WNT9A, CBLC, CSF1R, WNT7B, CDH1, ERBB2, FZD10, LAMA3, TRAF6, FGF11, MMP9, RXRA, BCR, FGFR2, TRAF4, PLD1, PDGFA, PIK3R2, PLCG2, RALB, LAMB3, EGLN3, WNT7A, RAC2, WNT4, VEGFB, LAMC2, DVL3, IKBKB, MAPK3, RALGDS, PML, PDGFB, RARA, BMP2, FLT3LG, PIK3CA, JUP, RASSF5, WNT10A, FADD, RXRB, MET, IGF1R, FGF1, MAX, ITGA3, EP300, EGFR, GLI3, STAT5B, E2F1, DAPK1, RALBP1, FGFR3, ITGA2B, PPARG, CBLB, ARNT2, STAT3, BRAF, PLCG1, CDKN1B, RELA, TCF7L1, FZD4, TGFA, FOXO1, IL6, DVL2, MECOM, LAMA5, WNT11, RUNX1, BAD, PGF, PIAS3, LAMB1, EPAS1, ITGA2, VEGFA, FGF12, DAPK2, PIK3R3, HIF1A, STAT1, CCNA1, CCNE1, STK4, TGFB3, CRKL, PTCH1, RALA, MITF, SLC2A1, STAT5A, VEGFC, RAC1, JAK1, BID, TGFBR2, BAX, MAPK1, WNT5A, MAPK10, PIK3R5, TFG, PIK3CB, CEBPA, NFKBIA, PTEN",0.112382699664264,0,FALSE
+"transcriptomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.47895,1.39,0.0806,4741,0.652,"DHDH, UGT2B17, GUSB, RPEL1, DCXR",1.09366495819491,0.18575240426808,FALSE
+"transcriptomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.43515,1.26,0.143,5085,0.73,"PGLS, ALDOC, FBP1, PGM1, PFKL, FBP2, ALDOA, H6PD, G6PD, RPEL1, RBKS, DERA, PGM2",0.844663962534938,0.136677139879544,FALSE
+"transcriptomics","Log2FC","KEGG_PEROXISOME",0.42548,1.24,0.154,5270,0.729,"CAT, ACOT8, GSTK1, PRDX5, PEX11A, XDH, PXMP4, ACAA1, MVK, AGXT, PEX11G, PEX2, HMGCL, EPHX2, PAOX, IDH2, ACSL1, EHHADH, PEX11B, CROT, ABCD1, ACOX1, ACSL3, PEX10, PEX13, PEX26, SCP2, PEX7, MLYCD, SLC25A17, ABCD4, PEX1, ACSL5, ACSL6",0.812479279163537,0.137272471682025,FALSE
+"transcriptomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",0.40531,1.17,0.206,5148,0.738,"ALDH3B2, ALDH1A3, ALDH3B1, AOC2, NAA80, IL4I1, TAT, MAOA, MIF",0.686132779630847,0.131943638176958,FALSE
+"transcriptomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.30436,0.88,0.655,6064,0.98,"CDS1, DGKA, PIK3R2, PLCG2, INPP4B, PLCD1, CALML3, INPP4A, PIK3CA, PIP4K2C, CDS2, PLCG1, PIK3C2G, PIK3C2B, DGKH, INPP5K, IMPA2, PIK3R3, PIP5K1C, CALML6, DGKI, ITPR3, INPPL1, INPP5J, PIK3R5, PIK3CB, DGKE, PTEN, PLCB3",0.183758700008217,0.00877392430750515,FALSE
+"transcriptomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.31034,0.889,0.63,4098,0.966,"ALAD, CP, HMOX2, FTH1, UGT2B17, MMAB, GUSB, HMBS",0.200659450546418,0.0150228735845067,FALSE
+"transcriptomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.41424,1.19,0.21,5270,0.722,"RXRA, ACAA1, CPT1B, PPARA, PLIN1, CYP4A22, FABP6, ACSL1, RXRB, CPT2, CPT1C, EHHADH, SLC27A6, PLTP, SLC27A1, PPARG, ACOX1, ACSL3, SCD5, SLC27A4, SCP2, OLR1, ACSL5, ACSL6",0.677780705266081,0.141462802430361,FALSE
+"transcriptomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.20209,-0.718,0.886,14148,1,"ACOX2, HSD17B4, CYP7A1, HSD3B7, AKR1C4, CYP39A1, BAAT",0.0525662781129492,0,FALSE
+"transcriptomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",0.5701,1.64,0.0143,4719,0.352,"RFXANK, BLNK, RAG1, JAK3, CD40, ADA, CD79A, RAG2, CD19, IL7R, CIITA, LCK, CD4",1.84466396253494,0.453457336521869,FALSE
+"transcriptomics","Log2FC","KEGG_PRION_DISEASES",0.24524,0.717,0.885,5622,1,"MAPK3, CCL5, IL6, NOTCH1, PRKACA, IL1A, C9, BAX, MAPK1, EGR1",0.0530567293021746,0,FALSE
+"transcriptomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28022,-1.01,0.396,15860,0.714,"ADCY7, PRKX, RPS6KA3, CCNA2, AKT3, MAD2L2, BUB1, CDC25C, CDC23, PIK3R1, GNAI1, PIK3CG, CCNB2, ANAPC10, PRKACB, CDK1, CCNB3, CDC25A, CCNB1, MAPK8, CPEB1, IGF1, HSP90AB1, HSP90AA1, ANAPC13, PDE3A, PDE3B",0.402304814074488,0.146301788223826,FALSE
+"transcriptomics","Log2FC","KEGG_PROPANOATE_METABOLISM",0.35657,1.04,0.37,3581,0.766,"LDHC, ACSS2, ALDH6A1, ABAT, MCEE, EHHADH, PCCB, ACSS1",0.431798275933005,0.115771230367396,FALSE
+"transcriptomics","Log2FC","KEGG_PROSTATE_CANCER",0.26783,0.773,0.834,6422,1,"ERBB2, FGFR2, PDGFA, PIK3R2, IKBKB, MAPK3, PDGFB, PIK3CA, IGF1R, PDGFD, EP300, EGFR, E2F1, BRAF, CDKN1B, RELA, TCF7L1, CREB3L4, TGFA, FOXO1, BAD, PIK3R3, CCNE1, CREB3L3, CREB3L2, MAPK1, CREB5, CREB3L1, PIK3R5, PIK3CB, NFKBIA, PTEN, GSK3B, CDKN1A, CREB3",0.0788339493622613,0,FALSE
+"transcriptomics","Log2FC","KEGG_PROTEASOME",-0.31612,-1.11,0.267,15132,0.637,"PSMB5, PSMD4, PSMD6, PSMC5, PSMB4, PSMA6, PSMD7, PSMC1, PSMC6, PSMD1, PSMC4, PSMB7, PSMA4, PSMA1, PSMD8, PSMB1, POMP, PSMD14",0.573488738635425,0.19586056766465,FALSE
+"transcriptomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.31244,-1.09,0.327,16054,0.584,"SEC61A2, SEC11A, SRPRB, SRP72, SRP9, SRP19, SEC11C, SEC63",0.485452247339714,0.233587152887601,FALSE
+"transcriptomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.19349,0.564,0.994,8289,1,"GLS2, SLC9A3, SLC25A10, MDH1, SLC4A4, GLUD1, ATP1A2, AQP1, ATP1A1",0.00261361560268669,0,FALSE
+"transcriptomics","Log2FC","KEGG_PURINE_METABOLISM",-0.30249,-1.01,0.33,15717,0.714,"PNPT1, PRPS1, RRM2, ADCY7, PFAS, POLR3B, ENTPD8, POLR2L, RRM2B, PAICS, ADSL, APRT, GART, NPR2, RRM1, PDE6B, PNP, PRIM1, NME1, PDE6C, POLR3G, PDE8A, POLR3A, AK5, NME7, PPAT, PDE11A, PRIM2, POLE3, POLR2E, POLR3C, PDE1A, ATIC, ENTPD1, PDE4B, PDE4D, POLR2D, POLR1E, PDE3A, PDE3B, POLA1, PDE10A, PDE7B, PDE8B",0.481486060122112,0.146301788223826,FALSE
+"transcriptomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.25943,-0.931,0.538,14988,0.82,"DHODH, POLE, NT5E, NME2, UPP2, CAD, POLR2C, POLR3K, PNPT1, RRM2, POLR3B, ENTPD8, POLR2L, RRM2B, AK3, TXNRD1, DTYMK, RRM1, PNP, PRIM1, NME1, TYMS, POLR3G, POLR3A, NME7, PRIM2, POLE3, POLR2E, POLR3C, ENTPD1, POLR2D, POLR1E, UCK2, POLA1, CTPS1",0.269217724333611,0.0861861476162833,FALSE
+"transcriptomics","Log2FC","KEGG_PYRUVATE_METABOLISM",0.22031,0.64,0.966,1378,0.993,"LDHC, ACSS2, PC",0.0150228735845067,0.00305075150461883,FALSE
+"transcriptomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.28027,0.805,0.792,5612,1,"PAK6, SSH3, BDKRB2, MYH14, BAIAP2, FGF11, ITGB2, VAV1, FGFR2, ITGB6, PDGFA, PIK3R2, ITGB8, RAC2, VAV3, LIMK2, FGD3, ITGB4, ARHGEF4, MAPK3, PPP1CA, VAV2, GSN, PDGFB, PFN4, PIK3CA, PPP1CB, PIP4K2C, BDKRB1, FGF1, SSH2, PDGFD, ITGA3, EGFR, FGFR3, ITGA2B, BRAF, TIAM1, PXN, MYL9, TIAM2, ARHGAP35, PAK2, SLC9A1, ITGA2, WASL, FGF12, PIK3R3, PIP5K1C, LIMK1, CRKL, ARHGEF7, SCIN, MYL7, RAC1, IQGAP1, PAK1, RRAS, BCAR1, ITGAX, PAK4, MAPK1",0.101274818410506,0,FALSE
+"transcriptomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.20206,-0.706,0.897,18035,1,"PIK3C3, PRKAA2, IFNA13",0.0472075569559079,0,FALSE
+"transcriptomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3643,1.05,0.363,5894,0.756,"GAB1, PAK6, PIK3R2, EGLN3, VEGFB, MAPK3, PDGFB, PIK3CA, MET, EP300, RAP1A, ARNT2, BRAF, TGFA, PAK2, PGF, EPAS1, VEGFA, PIK3R3, HIF1A, TGFB3, CRKL, FLCN, SLC2A1, VEGFC, RAC1, PAK1, PAK4, MAPK1, PIK3R5, PIK3CB",0.440093374963888,0.121478204498793,FALSE
+"transcriptomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.39819,1.15,0.235,4025,0.711,"CTSA, ACE2, ACE, ANPEP",0.628932137728264,0.148130399270234,FALSE
+"transcriptomics","Log2FC","KEGG_RETINOL_METABOLISM",0.43832,1.28,0.125,5807,0.772,"ADH7, RDH16, CYP26B1, DHRS9, DHRS3, DGAT1, CYP4A22, CYP26A1, UGT2B17, CYP1A1, RDH10, RDH11, LRAT, CYP26C1, CYP2C9, CYP2A7, ALDH1A2, AWAT2, CYP2C8",0.903089986991944,0.112382699664264,FALSE
+"transcriptomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.28656,0.826,0.747,3165,1,"ACP6, ACP5, MTMR1",0.126679398184601,0,FALSE
+"transcriptomics","Log2FC","KEGG_RIBOSOME",-0.37924,-1.29,0.169,14672,0.494,"RPL22L1, RPS23, RPL26, RPL21, RPL13A, RPS24, RPL10A, RPL37A, RPS11, RPS27A, RPL35, RPL10, RPL26L1, RPL34, RPL27A, RPLP0, RPL11, RPL32, RPS8, RPL18, RPS27, RPL9, RPS20, RPS10, RPS6, RPL4, RPL5, RPL14, RPSA, RPS13, RPS7, RPS19, RSL24D1, RPS12, RPL6, RPS4Y1, RPS16, RPL17",0.772113295386326,0.306273051076353,FALSE
+"transcriptomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.42041,1.22,0.17,3761,0.712,"TRADD, TRAF6, DHX58, MAPK13, MAVS, IRF3, CXCL10, IKBKB, IFNB1, MAP3K1, TKFC, FADD, ISG15, IFIH1, DDX58, NLRX1, IL12B, CASP10, RELA, MAPK11, IKBKE",0.769551078621726,0.147520006363144,FALSE
+"transcriptomics","Log2FC","KEGG_RNA_DEGRADATION",-0.39068,-1.41,0.0702,15014,0.339,"CNOT7, LSM2, EXOSC6, LSM1, LSM5, CNOT1, PNPT1, DCP1A, LSM7, EDC4, LSM3, EXOSC9, CNOT10, EXOSC5, EXOSC3, PAPOLA, TTC37, ZCCHC7, EXOSC10, MTREX, ENO1, DCP2, CNOT9, ENO3, EXOSC8, HSPA9, DCP1B, HSPD1",1.15366288787019,0.469800301796918,FALSE
+"transcriptomics","Log2FC","KEGG_RNA_POLYMERASE",-0.36582,-1.22,0.208,17492,0.515,"POLR3G, POLR3A, POLR2E, POLR3C, POLR2D, POLR1E",0.681936665037238,0.288192770958809,FALSE
+"transcriptomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",-0.20795,-0.735,0.909,17399,1,"SCLY, MAT2A, MARS2, SEPHS1, TRMT11",0.0414361167780325,0,FALSE
+"transcriptomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.2741,0.794,0.807,4622,1,"LAMA3, TRAF6, RXRA, TRAF4, PIK3R2, LAMB3, LAMC2, IKBKB, PIK3CA, RXRB, MAX, ITGA3, E2F1, ITGA2B, CDKN1B, RELA, LAMA5, PIAS3, LAMB1, ITGA2, PIK3R3",0.0931264652779296,0,FALSE
+"transcriptomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.44073,1.28,0.13,4358,0.772,"SNAP23, STX16, STX10, VAMP8, STX19, YKT6, STX17, VTI1B, TSNARE1, STX3, GOSR2, SNAP29, BET1, USE1, STX5, BET1L",0.886056647693163,0.112382699664264,FALSE
+"transcriptomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.24714,0.704,0.913,8272,0.99,"ARSA, SPTLC2, NEU1, ASAH1, PLPP3, DEGS2, SPHK2, GLB1, SPHK1, GBA, SGMS2, SGPP1, SPTLC1, ENPP7, UGCG, SMPD3, SMPD2, SGPP2, NEU2, SMPD1, UGT8",0.039529222465701,0.00436480540245009,FALSE
+"transcriptomics","Log2FC","KEGG_SPLICEOSOME",-0.28279,-0.977,0.457,14820,0.764,"HSPA1A, SNRNP27, DDX23, LSM2, SF3A3, SF3B1, SNRPB, SNRPF, PRPF8, BCAS2, LSM5, PRPF3, THOC1, SRSF3, SF3A2, DDX39B, EIF4A3, LSM7, SF3B4, TCERG1, RBM22, U2AF1, LSM3, SNRNP40, SYF2, DDX5, HNRNPK, DHX15, HNRNPA1L2, BUD31, PQBP1, PRPF40A, THOC2, PRPF4, SNRPA1, RBM8A, ALYREF, CDC5L, RBM17, SRSF7, SNRPE, PRPF18, SNRPD2, CDC40, SNRPC, RBMX, SRSF1, HNRNPA3, HSPA8, HNRNPM, HNRNPA1, HNRNPC, SF3B5, MAGOHB, PPIH, HNRNPU, PPIE, TXNL4A, SRSF10",0.34008379993015,0.11690664142431,FALSE
+"transcriptomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44369,1.28,0.138,7075,0.772,"HK2, GYS1, GCK, GAA, PGM1, GANC, UGT2B17, GUSB, HK1, UXS1, PYGL, PGM2, ENPP1, MGAM, PYGB, AMY1A, UGP2, AGL",0.860120913598763,0.112382699664264,FALSE
+"transcriptomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.61834,1.78,0.00441,5003,0.457,"MSMO1, DHCR24, LIPA, SC5D, SQLE, FDFT1, HSD17B7, CEL, NSDHL, DHCR7, LSS, TM7SF2",2.35556141053216,0.34008379993015,FALSE
+"transcriptomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38862,1.1,0.305,4669,0.737,"CYP11B1, CYP1B1, SULT2B1, SRD5A1, COMT, SRD5A3, CYP7B1, UGT2B17, HSD17B7, SULT1E1, CYP1A1, HSD17B8",0.515700160653214,0.132532512140949,FALSE
+"transcriptomics","Log2FC","KEGG_SULFUR_METABOLISM",0.55174,1.58,0.02,5093,0.399,"SULT2B1, CHST12, SULT1A2, SUOX, SULT1A4, CHST11, SULT1E1, SULT1A3",1.69897000433602,0.399027104313252,FALSE
+"transcriptomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.21402,-0.767,0.802,18576,1,"SSB, GRIN2B",0.0958256317158365,0,FALSE
+"transcriptomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.22218,0.638,0.958,6205,0.988,"KCNB1, SCNN1A, ADCY4, TAS2R1, SCNN1G, TAS1R3, ADCY6, GNAS, TAS2R3, GRM4, TAS2R31, SCNN1B, ITPR3, PRKACA, TAS2R4, TAS2R38, TAS2R5",0.0186344909214556,0.00524305541237188,FALSE
+"transcriptomics","Log2FC","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.24456,0.719,0.901,3450,1,"GGT7, GGT6",0.045275209020937,0,FALSE
+"transcriptomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.41775,1.21,0.176,5412,0.727,"MVK, HMGCS1, MVD, DHDDS, HMGCR",0.75448733218585,0.138465589140962,FALSE
+"transcriptomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21463,-0.748,0.836,15652,1,"SMAD7, TFDP1, RHOA, BMPR2, SMAD5, PITX2, BMP8B, PPP2CB, PPP2R1B, ID3, SMAD4, SKP1, SMURF2, BMPR1A, INHBE, SMAD9, BMP8A, ID2, TGFB1, CDKN2B, E2F5, ROCK2, BMP6, SMAD2",0.0777937225609836,0,FALSE
+"transcriptomics","Log2FC","KEGG_THYROID_CANCER",0.39121,1.14,0.227,3392,0.715,"CDH1, RXRA, MAPK3, RXRB, PPARG, BRAF, TCF7L1",0.643974142806877,0.145693958198919,FALSE
+"transcriptomics","Log2FC","KEGG_TIGHT_JUNCTION",0.33254,0.958,0.527,4350,0.881,"EPB41L1, PRKCD, AMOTL1, MYH14, CLDN8, CGN, CLDN9, CLDN7, CLDN4, F11R, TJP3, CRB3, TJP2, PRKCH, LLGL2, CLDN18, PRKCI, PARD6B, PATJ, CLDN11, CTTN, EXOC4, CLDN23, CLDN3, SRC, MYH15, MYL9, EXOC3, MAGI1, PRKCZ, OCLN",0.278189384787453,0.0550240915879521,FALSE
+"transcriptomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43206,1.26,0.127,6260,0.73,"TLR5, TRAF6, MAPK13, PIK3R2, IRF5, LBP, IRF3, TOLLIP, CXCL10, IKBKB, MAPK3, TLR3, IFNB1, PIK3CA, MYD88, FADD, CXCL11, CCL5, CD40, IL12B, CXCL9, TAB1, RELA, TLR1, MAPK11, IKBKE, IL6, TLR2, MAP3K8, IRAK4, TIRAP, TICAM1, PIK3R3, STAT1, IL12A, RAC1, TAB2, MAPK1, MAP2K7, MAPK10, PIK3R5, PIK3CB, NFKBIA, FOS, IRF7",0.896196279044043,0.136677139879544,FALSE
+"transcriptomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",0.25994,0.758,0.85,5698,0.999,"CAT, CYP1B1, GCDH, KMO, EHHADH, IL4I1, CYP1A1, MAOA, IDO1, HAAO, OGDHL",0.0705810742857073,0.000434511774017692,FALSE
+"transcriptomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",0.35999,1.05,0.353,1965,0.756,"PRKCD, HK2, PIK3R2, CACNA1D, SOCS1, GCK, IKBKB, MAPK3, INSR, PIK3CA",0.452225294612177,0.121478204498793,FALSE
+"transcriptomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",-0.22684,-0.798,0.842,16990,1,"PRF1, PTPRN, HSPD1",0.0746879085003505,0,FALSE
+"transcriptomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.48583,1.4,0.0669,2773,0.658,"ADH7, ALDH3B2, HEMK1, TH, ALDH1A3, ALDH3B1, COMT, AOC2, GSTZ1, NAA80, LCMT1",1.17457388223218,0.181774106386044,FALSE
+"transcriptomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29483,0.849,0.722,6624,0.989,"PAK6, CBLC, VAV1, MAPK13, PIK3R2, VAV3, DLG1, IKBKB, MAPK3, PTPN6, VAV2, PIK3CA, CARD11, NCK2, CBLB, PLCG1, RELA, CHP1, MAPK11, PPP3CA, PAK2, LCK, MAP3K8, CSF2, PIK3R3, CD4, NCK1, PAK1, PAK4, MAPK1, MAP2K7, NFATC1, PIK3R5, PIK3CB, NFKBIA, GSK3B, FOS, NFATC4, GRB2, CHP2",0.141462802430361,0.0048037084028206,FALSE
+"transcriptomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29203,0.86,0.693,6099,0.973,"CBLC, UBOX5, ITCH, UBA7, TRAF6, UBE2H, PPIL2, SOCS1, FBXO2, SMURF1, PML, MAP3K1, FBXW7, UBE2L6, RHOBTB2, HERC1, HERC3, ANAPC2, CUL7, UBE2D4, CBLB, FBXO4, RNF7, MID1, SYVN1, UBA6, FBXW8, UBR5, UBE2C, PIAS3, KLHL13, UBE3B, UBE2W, HUWE1, NEDD4L, UBE2F, TRIM32, UBE2Q1, WWP2, DDB1, SIAH1, FZR1, UBE4A, UBE2E1, UBE3C, DET1, UBE2O, UBE2E2, STUB1, UBA3, ANAPC11, UBE2M, UBE2Z",0.159266765388193,0.0118871597316481,FALSE
+"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.54815,-1.88,0.02,13596,0.161,"VARS2, LARS2, BCAT1, PDHA1, IARS2",1.69897000433602,0.79317412396815,TRUE
+"transcriptomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.42231,1.22,0.182,3822,0.712,"MCCC1, ACAA1, HIBADH, ACAD8, ALDH6A1, ABAT, HMGCL, HMGCS1, MCEE, ACADS, EHHADH, PCCB, IL4I1, AUH",0.739928612014925,0.147520006363144,FALSE
+"transcriptomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28813,0.847,0.739,4348,0.985,"PRKCD, PLA2G12A, KCNMB3, CACNA1D, PLA2G6, CALML3, PLA2G4B, ADORA2B, MAPK3, ADORA2A, PPP1CA, PRKCH, ADCY5, CYP4A22, PPP1CB, ADCY4, PLA2G10, PLA2G4E, BRAF, ADCY6, MYL9, PLA2G2C, EDNRA, KCNMB4, GNAS, GNAQ",0.131355561605174,0.00656376950238827,FALSE
+"transcriptomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.27394,0.798,0.785,7785,1,"DYNLL2, AQP3, RAB5B, ARHGDIB, ADCY6, CREB3L4, GNAS, DYNC2LI1, DCTN5, CREB3L3, PRKACA, CREB3L2, RAB11B, RAB5C, CREB5, CREB3L1, CREB3, ADCY9, ADCY3, NSF, CREB1, RAB11A, PRKACG, DCTN1",0.105130343254747,0,FALSE
+"transcriptomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.37587,1.09,0.307,5894,0.756,"PLA2G12A, MAPK13, PIK3R2, PLCG2, RAC2, PLA2G6, PLA2G4B, NOS3, HSPB1, MAPK3, PIK3CA, PLA2G10, PLA2G4E, MAPKAPK3, PLCG1, SPHK2, PXN, SRC, CHP1, MAPK11, PPP3CA, PLA2G2C, BAD, VEGFA, PIK3R3, SPHK1, MAPKAPK2, RAC1, MAPK1, NFATC1, PIK3R5, PIK3CB",0.512861624522813,0.121478204498793,FALSE
+"transcriptomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.35881,1.05,0.364,7679,0.756,"ERO1A, PLCG2, ATP6V1C2, TJP2, ATP6V0D2, ATP6V1B1, ATP6V1F, ATP6AP1, KDELR3, PLCG1, PDIA4, GNAS, TCIRG1, KCNQ1, ATP6V1G1, SEC61G, ATP6V0A4, PRKACA, KDELR2, ATP6V1C1, TJP1, ATP6V1E1, ADCY9, ADCY3, SEC61B, ATP6V0C, PRKACG, ATP6V1E2, ATP6V0E2",0.438898616350944,0.121478204498793,FALSE
+"transcriptomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.26233,0.751,0.855,3633,0.986,"MYH14, ITGB2, RAC2, DAG1, CD40, EIF4G1, CAV1, MYH15",0.0680338852718274,0.0061230850587888,FALSE
+"transcriptomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.25146,0.726,0.884,2541,1,"WNT3A, WNT9A, TBL1XR1, WNT7B, DAAM1, FZD10, PORCN, WNT7A, RAC2, SENP2, WNT4, FRAT1, CTNNBIP1, DVL3, CAMK2G, FRAT2, CSNK1E, WNT10A, LRP5, CSNK1A1, EP300, VANGL2",0.0535477349869269,0,FALSE
+"proteomics","Log2FC","KEGG_ABC_TRANSPORTERS",-0.56716,-1.68,0.037,8609,0.508,"ABCC5, ABCA1, ABCG1, ABCA10, ABCB1, ABCC10, ABCB7, ABCB5, ABCC1, ABCC4, ABCC6, ABCB4, ABCB10, ABCA7, ABCA3, ABCA13, ABCC2, ABCB11",1.431798275933,0.294136287716081,FALSE
+"proteomics","Log2FC","KEGG_ACUTE_MYELOID_LEUKEMIA",0.42626,1.21,0.208,2845,0.611,"PIK3CD, RARA, RUNX1, LEF1, CCND1, KRAS, NRAS, FLT3, PIK3R2, PIK3CA, STAT3, IKBKB, HRAS, EIF4EBP1, MAPK3, GRB2, RPS6KB2, SOS2, TCF7L1, MAPK1",0.681936665037238,0.213958789757446,FALSE
+"proteomics","Log2FC","KEGG_ADHERENS_JUNCTION",0.47199,1.35,0.113,1296,0.576,"RAC2, NECTIN4, CDH1, SNAI2, CTNND1, ACTN3, CTNNA1, NECTIN1, CTNNA2, CTNNB1, BAIAP2, ERBB2, RAC3, EP300, LMO7, PTPN6, PTPRF, EGFR, LEF1",0.94692155651658,0.239577516576788,FALSE
+"proteomics","Log2FC","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.31768,0.883,0.577,2689,0.999,"CD36, RXRA, RXRG, IRS1, ACSL4, ACSL1, PRKCQ, ACSL6, SLC2A1, ACSL5, STAT3, IKBKB, NFKBIA, PRKAB2, ACSL3",0.238824186844269,0.000434511774017692,FALSE
+"proteomics","Log2FC","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.24638,0.697,0.875,2010,1,"GLUL, ABAT, GLUD2, GFPT1, GPT2",0.0579919469776868,0,FALSE
+"proteomics","Log2FC","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.56793,1.6,0.0445,3523,0.561,"SCNN1A, ATP1A2, PIK3CD, IRS1, PDPK1, KRAS, HSD11B2, PIK3R2, PIK3CA, MAPK3, SCNN1B, MAPK1, SFN, ATP1A3, ATP1A4, ATP1A1, PRKCG",1.35163998901907,0.251037138743839,FALSE
+"proteomics","Log2FC","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.58978,1.63,0.0413,2132,0.638,"FADS2, PLA2G12A, PLA2G2A, ACOX1, ACOX3",1.3840499483436,0.195179321278838,FALSE
+"proteomics","Log2FC","KEGG_ALZHEIMERS_DISEASE",-0.26665,-0.782,0.738,8102,0.881,"PSEN1, NDUFV1, UQCRC1, COX7A2, NDUFA6, ERN1, NDUFC1, BAD, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, MAPT, ATP5PF, NDUFB4, HSD17B10, NDUFA3, ITPR2, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, IDE, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, PPP3CC, ITPR1, PLCB2, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5MC2, BACE2, CASP7, PLCB4, PSEN2",0.131943638176958,0.0550240915879521,FALSE
+"proteomics","Log2FC","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.38256,-1.16,0.237,7208,0.551,"AARS2, FARSB, FARS2, SARS2, LARS2, DARS2, YARS2, MTFMT, EARS2, WARS2, RARS2",0.625251653989896,0.258848401148215,FALSE
+"proteomics","Log2FC","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.27352,0.756,0.778,2412,1,"HK1, MPI, NPL, RENBP, PGM1, NAGK, GMPPA, GFPT1, HK2, GALT, PGM2, GALE",0.109020403010311,0,FALSE
+"proteomics","Log2FC","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.34389,-0.985,0.441,10318,0.668,"NEFM, MAP2K6, MAPK11, SOD1, NEFL, PRPH, PRPH2, NEFH",0.355561410532161,0.175223537524454,FALSE
+"proteomics","Log2FC","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32022,0.881,0.594,3597,0.989,"CTSS, IFI30, CD74, CALR, LGMN, HSPA6, TAPBP, HSPA1A, PSME2, CREB1, PSME1, CTSB",0.226213555018806,0.0048037084028206,FALSE
+"proteomics","Log2FC","KEGG_APOPTOSIS",0.23693,0.666,0.911,2534,1,"IL1R1, BCL2, IL1RAP, ENDOD1, PIK3CD, CASP10, MYD88, PPP3R1, PPP3CA, PPP3CB, PPP3R2, PIK3R2, TP53, CASP6, PIK3CA, IKBKB, PRKAR1B, CAPN2, NFKBIA, ENDOG",0.0404816230270017,0,FALSE
+"proteomics","Log2FC","KEGG_ARACHIDONIC_ACID_METABOLISM",0.4694,1.33,0.125,2120,0.597,"GGT5, PTGS2, PLA2G12A, EPHX2, ALOX5, GPX6, GPX7, PTGES, PLA2G2A, GPX1, GGT7, GPX3",0.903089986991944,0.224025668870631,FALSE
+"proteomics","Log2FC","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34932,0.983,0.453,2841,0.905,"GLUL, OAT, PRODH, PRODH2, GATM, ARG1, NOS3, CKMT1A, CKMT2, GLUD2, NOS1, P4HA2, NAGS, ARG2, P4HA1, PYCR3, MAOA, ASL, OTC, ALDH18A1",0.343901797987168,0.0433514207947967,FALSE
+"proteomics","Log2FC","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.33473,0.926,0.513,1866,0.961,"ITGB6, ITGB8, ACTN3, CTNNA1, ITGB4, CTNNA2, CTNNB1, DSC2, ITGA2, ITGA11, SGCG, LEF1, ITGA4, CACNA1F, GJA1, ITGA3, PKP2",0.289882634888184,0.0172766123314547,FALSE
+"proteomics","Log2FC","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.61182,-1.82,0.0194,7847,0.331,"ALDH9A1, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",1.71219827006977,0.480172006224281,FALSE
+"proteomics","Log2FC","KEGG_AXON_GUIDANCE",0.46405,1.3,0.155,2598,0.539,"RAC2, PAK5, PAK6, NGEF, EPHA1, EPHB2, RGS3, ROBO2, NTN4, SEMA4B, NFATC4, EFNB2, EFNA1, SEMA7A, RAC3, PLXNB2, PPP3R1, SEMA3A, SEMA3C, PPP3CA, PPP3CB, PLXNA2, EPHB4, PPP3R2, EPHA4, SEMA4D, KRAS, NRAS, SLIT2, EPHB3, EPHB1, RHOA, NFATC1, SLIT1, SLIT3, RAC1, MET, LIMK2, HRAS, MAPK3, PLXNA1, ABLIM1, NFATC3, NTN1, NFATC2, RHOD",0.809668301829709,0.268411234813261,FALSE
+"proteomics","Log2FC","KEGG_BASAL_CELL_CARCINOMA",-0.25512,-0.759,0.782,10364,0.882,"WNT10A, GLI2, GLI3",0.106793246940152,0.0545314148681803,FALSE
+"proteomics","Log2FC","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.41284,-1.19,0.222,7232,0.554,"GTF2A1, STON1, GTF2E2, TAF10, TBP, GTF2H3, GTF2A2, GTF2F2, GTF2H4, GTF2H1, TAF12, GTF2H2, GTF2F1, TAF13, TBPL1",0.653647025549361,0.25649023527157,FALSE
+"proteomics","Log2FC","KEGG_BASE_EXCISION_REPAIR",-0.24796,-0.732,0.82,9965,0.902,"POLL, NTHL1, MUTYH",0.0861861476162833,0.0447934624580583,FALSE
+"proteomics","Log2FC","KEGG_BETA_ALANINE_METABOLISM",-0.28968,-0.838,0.61,7434,0.796,"SRM, ECHS1, MLYCD, ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, ALDH2, ALDH7A1",0.214670164989233,0.0990869322623309,FALSE
+"proteomics","Log2FC","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.35293,-1.03,0.356,9642,0.653,"HACD1, YOD1, PECR, ACOT7, ELOVL2",0.448550002027125,0.185086818724926,FALSE
+"proteomics","Log2FC","KEGG_BLADDER_CANCER",0.463,1.32,0.129,2596,0.575,"CDH1, VEGFA, THBS1, ERBB2, VEGFC, EGFR, CDK4, CCND1, KRAS, NRAS, CDKN1A, MMP2, TP53, HRAS, MAPK3, CDKN2A",0.889410289700751,0.24033215531037,FALSE
+"proteomics","Log2FC","KEGG_BUTANOATE_METABOLISM",0.29975,0.837,0.633,891,1,"ABAT, HMGCS1, ACSM3, BDH2",0.198596289982645,0,FALSE
+"proteomics","Log2FC","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.52452,1.49,0.0618,2561,0.572,"RAC2, DAPP1, CARD11, NFATC4, PIK3CD, RAC3, LYN, CD79A, PTPN6, PIK3AP1, PPP3R1, VAV1, PPP3CA, VAV2, PPP3CB, PPP3R2, KRAS, NRAS, CD81, NFATC1, PIK3R2, RAC1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, VAV3, GRB2, NFATC3, NFATC2, SOS2",1.20901152491118,0.242603971206976,FALSE
+"proteomics","Log2FC","KEGG_CALCIUM_SIGNALING_PATHWAY",0.24843,0.683,0.875,1708,1,"TNNC1, ERBB3, GNA15, TNNC2, NOS3, ERBB2, ERBB4, ATP2A3, PPP3R1, EGFR, PPP3CA, PPP3CB, PPP3R2, NOS1, PTK2B, CACNA1F, CACNA1A",0.0579919469776868,0,FALSE
+"proteomics","Log2FC","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.35378,0.994,0.413,840,0.892,"TNNC1, MYH7, ATP1A2, SLC9A1",0.384049948343599,0.0496351456238769,FALSE
+"proteomics","Log2FC","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.48094,1.36,0.133,793,0.604,"CLDN18, CLDN4, CLDN7, CDH15, CDH3, CDH5, SDC4, ITGAL, SDC1, ITGB8, ITGB2, CLDN3, CDH1, F11R, CLDN6, VCAN, JAM2, SDC2, NECTIN1, SDC3, CD274, ICAM2",0.876148359032914,0.218963061378868,FALSE
+"proteomics","Log2FC","KEGG_CELL_CYCLE",0.18042,0.514,0.989,2700,1,"FZR1, CDC6, WEE1, EP300, CDC7, CHEK2, ANAPC11, CDKN1C, CDK4, SKP2, CCND1, CCNB1, BUB1, CDKN1A, CCNA2, RBL1, CREBBP, TP53, PCNA, CHEK1, BUB1B, CDKN2A, HDAC1, ZBTB17",0.0048037084028206,0,FALSE
+"proteomics","Log2FC","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28479,-0.842,0.649,10271,0.801,"PLCB4, CXCL10, DOCK2, ADCY6, GNG7, SHC4, CCR10, CCR9, WAS, CXCL5, RASGRP2, CXCL14",0.187755303199631,0.0963674839157623,FALSE
+"proteomics","Log2FC","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.23803,0.664,0.913,2652,0.993,"PIK3CD, MECOM, RUNX1, CDK4, CCND1, KRAS, NRAS, CDKN1A, BCR, PIK3R2, TP53, PIK3CA, CTBP1, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, GRB2, SOS2, CDKN2A, HDAC1",0.039529222465701,0.00305075150461883,FALSE
+"proteomics","Log2FC","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.51999,1.46,0.0752,2428,0.601,"BHLHE41, PER2, NR1D1, CSNK1E, ARNTL",1.12378215940836,0.22112552799726,FALSE
+"proteomics","Log2FC","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.18745,-0.56,0.99,2896,0.996,"IDH1, SUCLG2, ACO1, DLD, ACLY, ACO2, DLST, PCK1, MDH2, MDH1, SDHA, SUCLG1, OGDHL, DLAT, OGDH, PC, SUCLA2, IDH3B, SDHB, CS, SDHC, IDH3A, PDHB, PDHA1, IDH3G, FH, SDHD, PCK2",0.00436480540245009,0.00174066157630127,FALSE
+"proteomics","Log2FC","KEGG_COLORECTAL_CANCER",0.32298,0.911,0.552,2210,0.955,"RAC2, BCL2, CTNNB1, PIK3CD, RAC3, LEF1, CCND1, KRAS, RHOA, PIK3R2, TP53, RAC1, PIK3CA",0.258060922270801,0.0199966284162537,FALSE
+"proteomics","Log2FC","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.403,1.11,0.287,944,0.696,"CFI, CFB, SERPINA1, TFPI, FGG, FGB, SERPINA5, MASP1, PLAT, PLAU, SERPINC1, F3",0.542118103266008,0.157390760389438,FALSE
+"proteomics","Log2FC","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.39207,-1.14,0.241,8054,0.566,"APIP, GOT1, MAT2B, SDS, GOT2, CBS, MAT2A, MAT1A, MTAP, AMD1, CDO1",0.617982957425132,0.247183568811729,FALSE
+"proteomics","Log2FC","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.46198,-1.39,0.103,10106,0.603,"TNFRSF10A, TGFB1, BMPR2, CXCL10, INHBA, TNFRSF19, ACVR2A, CD70, TNFSF9, TGFB2, CD40, BMPR1A, TNFRSF10C, CCR10, CCR9, IL1A, IFNAR2, CXCL5, INHBE, CXCL14, PDGFRA",0.987162775294828,0.219682687859849,FALSE
+"proteomics","Log2FC","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.16559,0.464,1,2883,1,"CASP1, RIPK3, DDX58, IL18, IKBKB, NFKBIA, IKBKE, IL1B",0,0,FALSE
+"proteomics","Log2FC","KEGG_DILATED_CARDIOMYOPATHY",-0.30863,-0.912,0.509,10453,0.713,"ADCY6, TGFB2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.293282217663241,0.146910470148134,FALSE
+"proteomics","Log2FC","KEGG_DNA_REPLICATION",-0.20491,-0.61,0.962,2252,1,"PCNA, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, POLE4, POLD3, RFC4, MCM4, POLE3, MCM6, POLD1, MCM5, MCM7, RPA2, SSBP1, RNASEH2A, MCM3, POLE2, POLD2, FEN1, PRIM1, RPA1, MCM2, DNA2, RNASEH1, PRIM2, POLA1, POLA2, RNASEH2C, RNASEH2B",0.0168249279621871,0,FALSE
+"proteomics","Log2FC","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55702,1.57,0.045,2561,0.481,"ETS2, ETV6, EGFR, NOTCH3, KRAS, PIWIL2, MAPK3, GRB2, SOS2",1.34678748622466,0.317854923626168,FALSE
+"proteomics","Log2FC","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.35951,1.01,0.423,1430,0.867,"FMO5, GSTA5, ADH4, ADH7, FMO2, FMO4, MGST2, ALDH1A3, MGST1, ALDH3B1, FMO3",0.373659632624958,0.0619809025237897,FALSE
+"proteomics","Log2FC","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42011,-1.23,0.195,9395,0.525,"GMPS, CYP3A5, UCK2, UMPS, NAT2, CYP3A7",0.709965388637482,0.279840696594043,FALSE
+"proteomics","Log2FC","KEGG_ECM_RECEPTOR_INTERACTION",0.43662,1.24,0.197,1082,0.577,"ITGB6, TNC, SDC4, CD36, SDC1, ITGB8, ITGB4, SDC2, LAMC2, LAMB3, THBS1, SDC3, CD47, ITGA2, ITGA11, LAMA3, LAMA4",0.705533773838407,0.238824186844269,FALSE
+"proteomics","Log2FC","KEGG_ENDOCYTOSIS",0.2991,0.833,0.674,2726,0.992,"EPN3, PSD4, ERBB3, ARRB1, CHMP2B, ASAP3, RAB11FIP1, RAB11FIP4, ERBB4, DNAJC6, ARAP3, EGFR, GRK2, AGAP1, TRAF6, PRKCZ, AGAP2, RAB22A, EHD2, PRKCI, PARD6G, ITCH, ARF6, RAB11B, RAB31, RAB11A, CHMP4C, MET, LDLRAP1, CHMP4A, CHMP4B, CHMP2A, CLTCL1, PARD6B, HRAS, EPS15, CBLB, IGF1R, HSPA6, VPS37B, RAB5B, PARD6A, EPN1",0.17134010346468,0.00348832784582135,FALSE
+"proteomics","Log2FC","KEGG_ENDOMETRIAL_CANCER",0.50929,1.41,0.102,2624,0.606,"CDH1, CTNNA1, CTNNA2, CTNNB1, ERBB2, PIK3CD, EGFR, LEF1, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, TCF7L1",0.991399828238082,0.217527375833714,FALSE
+"proteomics","Log2FC","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.31162,0.868,0.587,1141,0.992,"CXCL1, F11R, JAM2, MAPK12, MAPK13, LYN, EGFR",0.231361898752386,0.00348832784582135,FALSE
+"proteomics","Log2FC","KEGG_ERBB_SIGNALING_PATHWAY",0.41192,1.15,0.276,2561,0.697,"EREG, ERBB3, AREG, PAK5, PAK6, TGFA, ERBB2, PIK3CD, ERBB4, EGFR, GAB1, KRAS, NRAS, CDKN1A, PIK3R2, PIK3CA, HRAS, EIF4EBP1, MAPK3, CAMK2D, ABL2, CBLB, GRB2, RPS6KB2, SOS2",0.559090917934782,0.156767221901991,FALSE
+"proteomics","Log2FC","KEGG_ETHER_LIPID_METABOLISM",0.4815,1.36,0.137,2108,0.604,"LPCAT2, PLA2G12A, PAFAH2, PLA2G2A, LPCAT4, LPCAT1, PLPP3",0.863279432843593,0.218963061378868,FALSE
+"proteomics","Log2FC","KEGG_FATTY_ACID_METABOLISM",0.299,0.835,0.678,2361,1,"ADH4, ADH7, ACSL4, ACAA1, ACSL1, ACOX1, CPT2, ACSL6, ADH1C, ACOX3, ACADM, ACSL5, ACADS",0.168770306132937,0,FALSE
+"proteomics","Log2FC","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.46449,1.31,0.129,2664,0.537,"RAC2, PRKCD, MAPK12, PIK3CD, MAPK13, PLA2G12A, RAC3, LYN, VAV1, LCP2, VAV2, PLA2G2A, PDPK1, KRAS, NRAS, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, SOS2, MAPK14",0.889410289700751,0.270025714300444,FALSE
+"proteomics","Log2FC","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3637,1.01,0.405,2557,0.867,"RAC2, PRKCD, AMPH, ASAP3, SCIN, PIK3CD, LYN, VAV1, GSN, MYO10, HCK, VAV2, MARCKS, MARCKSL1, PLA2G4F, ARF6, PTPRC, PIK3R2, PLPP3, RAC1, PIK3CA, LIMK2, MAPK3, VAV3, RPS6KB2",0.392544976785331,0.0619809025237897,FALSE
+"proteomics","Log2FC","KEGG_FOCAL_ADHESION",0.29325,0.832,0.673,1355,0.981,"ITGB6, TNC, RAC2, BCL2, PAK5, PAK6, ITGB8, VEGFA, ACTN3, ITGB4, LAMC2, LAMB3, THBS1, CTNNB1, ERBB2, VEGFC, PIK3CD, RAC3, VAV1, ITGA2, ITGA11, LAMA3, LAMA4, EGFR, VAV2, PDPK1, CCND1",0.171984935776023,0.0083309926200515,FALSE
+"proteomics","Log2FC","KEGG_FOLATE_BIOSYNTHESIS",0.38519,1.09,0.318,2050,0.711,"ALPI, ALPP, ALPG, FPGS, PTS",0.497572880015567,0.148130399270234,FALSE
+"proteomics","Log2FC","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.59056,1.66,0.0345,2113,0.786,"ALDOB, FBP1, ALDOC, PFKFB4, MTMR7, HK1, FBP2, PFKFB2, MPI, GMPPA, MTMR1, HK2",1.46218090492673,0.104577453960592,FALSE
+"proteomics","Log2FC","KEGG_GALACTOSE_METABOLISM",0.35287,0.981,0.462,2908,0.894,"B4GALT1, HK1, PGM1, HK2, GAA, GALT, PGM2, GALE, UGP2, MGAM",0.335358024443874,0.0486624812040823,FALSE
+"proteomics","Log2FC","KEGG_GAP_JUNCTION",-0.39068,-1.13,0.254,9590,0.567,"GNAI1, ITPR1, PLCB2, TUBA8, TUBA3C, TUBB6, GRM5, PLCB4, MAP2K5, ADCY6, TUBB2B, PDGFRA",0.595166283380062,0.246416941107093,FALSE
+"proteomics","Log2FC","KEGG_GLIOMA",-0.32991,-0.973,0.446,10540,0.676,"CDK6, SHC4, PDGFRA",0.350665141287858,0.170053304058364,FALSE
+"proteomics","Log2FC","KEGG_GLUTATHIONE_METABOLISM",0.28325,0.797,0.743,2603,0.996,"GGT5, GSTA5, MGST2, GPX6, GPX7, MGST1, GSTK1, GPX1, IDH2, GGT7, GPX3, MGST3, G6PD, ANPEP, GSTT2",0.129011186239425,0.00174066157630127,FALSE
+"proteomics","Log2FC","KEGG_GLYCEROLIPID_METABOLISM",0.32775,0.925,0.512,2176,0.948,"LIPC, LPL, MGLL, LIPG, DGKA, DGKH, MBOAT2, DGKB, PLPP3, DGAT1",0.290730039024169,0.0231916626619338,FALSE
+"proteomics","Log2FC","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.34171,0.956,0.482,3460,0.928,"PEMT, DGKA, LPCAT2, PLA2G12A, CDS1, DGKH, PLA2G2A, CHKA, LPCAT4, MBOAT2, LPCAT1, DGKB, LYPLA2, PLPP3, PISD, PCYT2, LPGAT1, GPD1L, MBOAT1, DGKZ, PLA2G4A, GPD2, CHKB, LPCAT3, DGKQ",0.31695296176115,0.0324520237811379,FALSE
+"proteomics","Log2FC","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.30658,-0.896,0.565,9064,0.732,"CBS, AGXT, ALAS1, PHGDH, PIPOX, PSAT1, MAOB, GLDC",0.247951552180562,0.135488918941608,FALSE
+"proteomics","Log2FC","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.45991,1.31,0.131,881,0.537,"ALDOB, PGAM2, FBP1, ALDOC, ADH4, ADH7, GALM, HK1, FBP2, ACSS2, ALDH1A3",0.882728704344236,0.270025714300444,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34596,-1.02,0.372,9904,0.627,"XYLT1, CSGALNACT2, CHST3, CHST7",0.429457060118102,0.202732459169284,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34182,0.971,0.442,3070,0.904,"HS6ST2, HS6ST1, XYLT2, EXT2, EXT1, EXTL3",0.354577730650908,0.0438315695246367,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66613,1.85,0.0113,2887,0.765,"B4GALT1, FUT8, B4GALT3, ST3GAL1, B3GNT2, B4GALT4",1.94692155651658,0.116338564846382,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.43357,-1.27,0.195,9910,0.57,"HEXA, IDUA, ARSB, HYAL1",0.709965388637482,0.244125144327509,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51004,-1.47,0.0904,7952,0.584,"HEXB, ST3GAL5, HEXA, B4GALNT1",1.04383156952464,0.233587152887601,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.56837,1.59,0.053,725,0.481,"B3GALNT1, B3GALT5",1.27572413039921,0.317854923626168,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62329,1.76,0.011,2178,0.817,"B3GNT3, FUT3, B4GALT1, B3GALT5, B4GALT3, ST3GAL4, B3GNT2",1.95860731484178,0.0877779434675845,FALSE
+"proteomics","Log2FC","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.25881,-0.767,0.752,8687,0.882,"PIGN, PIGQ, PIGB, PIGM, PIGX",0.123782159408358,0.0545314148681803,FALSE
+"proteomics","Log2FC","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.16598,0.474,0.998,4328,1,"AFMID, GLYCTK, ACO1, ACO2, MDH2, MTHFD2L, MDH1, MTHFD1",0.000869458712628891,0,FALSE
+"proteomics","Log2FC","KEGG_GNRH_SIGNALING_PATHWAY",0.23616,0.653,0.91,3427,0.995,"PRKCD, MAPK12, MAPK13, PLA2G12A, CGA, EGFR, PLA2G2A, KRAS, NRAS, PTK2B, CACNA1F, MAP3K1, MMP2, PLCB1, HRAS, MAPK3, CAMK2D, GRB2, SOS2, MAPK14, MAPK1, PLA2G4A, MMP14, GNA11, ADCY9, CDC42, CAMK2B, PLCB3, SOS1, ADCY5",0.0409586076789064,0.00217691925427455,FALSE
+"proteomics","Log2FC","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30481,-0.883,0.56,10364,0.745,"WNT10A, GLI2, GLI3",0.2518119729938,0.127843727251707,FALSE
+"proteomics","Log2FC","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.29233,0.814,0.68,1843,0.984,"IL1R1, CD36, CD9, ITGA2, ITGA4, ITGA3, FLT3, CD33",0.167491087293764,0.00700490156865849,FALSE
+"proteomics","Log2FC","KEGG_HISTIDINE_METABOLISM",-0.34944,-1.02,0.398,10443,0.627,"ALDH2, MAOB, ALDH7A1, ALDH3A1",0.400116927926312,0.202732459169284,FALSE
+"proteomics","Log2FC","KEGG_HOMOLOGOUS_RECOMBINATION",-0.38362,-1.12,0.295,9496,0.536,"RAD50, MUS81, MRE11, RAD52",0.530177984021837,0.27083521030723,FALSE
+"proteomics","Log2FC","KEGG_HUNTINGTONS_DISEASE",-0.35692,-1.02,0.375,7298,0.627,"NDUFV2, COX7C, POLR2L, NDUFS4, SDHB, NDUFB5, POLR2I, COX4I1, POLR2A, SDHC, COX6B1, DCTN4, COX6A1, POLR2E, CYCS, DCTN2, DNAL1, TBP, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, POLR2H, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, BAX, NDUFA2, DCTN1, TFAM, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, HIP1, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, DNAH3, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, TGM2, ATP5F1C, SOD2, AP2A2, ITPR1, PLCB2, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, TBPL1, GRM5, PLCB4, BBC3, SOD1",0.425968732272281,0.202732459169284,FALSE
+"proteomics","Log2FC","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.32547,-0.949,0.454,10552,0.68,"TGFB2, PRKAA2, TPM2, LAMA2, CACNA2D2, SGCD, CACNA2D1, ITGA10, DES",0.342944147142896,0.167491087293764,FALSE
+"proteomics","Log2FC","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25705,0.73,0.81,3346,1,"IMPA2, INPP4B, PIK3CD, PIP4K2C, ALDH6A1, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1, ISYNA1, INPP5B, INPP5A, PIP4K2A, PI4KB, SYNJ2, PLCB3",0.0915149811213502,0,FALSE
+"proteomics","Log2FC","KEGG_INSULIN_SIGNALING_PATHWAY",0.20113,0.569,0.984,2750,1,"FBP1, PIK3CD, HK1, FBP2, PTPRF, IRS1, PDPK1, KRAS, NRAS, PRKCZ, PYGB, PRKCI, EXOC7, MKNK1, PIK3R2, HK2, PIK3CA, PTPN1, PPP1R3D, IKBKB, PRKAR1B, HRAS, EIF4EBP1, MAPK3, RHEB, CBLB, GRB2, RPS6KB2, SOS2, PRKAB2, PYGL, GYS1",0.00700490156865849,0,FALSE
+"proteomics","Log2FC","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50265,-1.47,0.0964,10060,0.584,"ICOSLG, TGFB1, CD40, CCR10, CCR9",1.01592296609717,0.233587152887601,FALSE
+"proteomics","Log2FC","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27492,0.772,0.76,2561,1,"SPRY2, LIFR, PIK3CD, EP300, PTPN6, STAT2, IL13RA1, IFNGR1, CCND1, IRF9, STAT1, OSMR, STAT6, SPRY1, CREBBP, PIK3R2, JAK1, PIAS3, PIK3CA, STAT3, CBLB, GRB2, SOS2",0.119186407719209,0,FALSE
+"proteomics","Log2FC","KEGG_LEISHMANIA_INFECTION",0.37967,1.06,0.336,2883,0.769,"ITGB2, PTGS2, MAPK12, MAPK13, MYD88, PTPN6, IFNGR1, STAT1, ITGA4, TRAF6, MARCKSL1, JAK1, MAPK3, NFKBIA, MAPK14, C3, MAPK1, IL1B",0.473660722610156,0.114073660198569,FALSE
+"proteomics","Log2FC","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.50535,1.41,0.105,809,0.606,"CLDN18, CLDN4, CLDN7, RAC2, CDH5, ITGAL, ITGB2, CLDN3, F11R, CLDN6, CTNND1, ACTN3, CTNNA1, JAM2, MAPK12, CTNNA2, CTNNB1, PIK3CD, MAPK13",0.978810700930062,0.217527375833714,FALSE
+"proteomics","Log2FC","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.6513,-1.88,0.0167,7847,0.425,"ALDH9A1, EHHADH, ALDH1B1, ALDH3A2, YOD1, ALDH2, ALDH7A1, NAA80",1.77728352885242,0.371611069949688,FALSE
+"proteomics","Log2FC","KEGG_LINOLEIC_ACID_METABOLISM",-0.568,-1.63,0.0607,10332,0.523,"PLA2G6, CYP3A7",1.21681130892474,0.281498311132726,FALSE
+"proteomics","Log2FC","KEGG_LONG_TERM_DEPRESSION",-0.22631,-0.661,0.91,9590,0.995,"GNAI1, ITPR1, PLCB2, GRM5, PLCB4, PLA2G6, PPP1R17",0.0409586076789064,0.00217691925427455,FALSE
+"proteomics","Log2FC","KEGG_LONG_TERM_POTENTIATION",0.24302,0.679,0.884,2407,0.994,"EP300, PPP3R1, PPP3CA, PPP3CB, PPP3R2, KRAS, NRAS, RPS6KA1, CREBBP, RPS6KA6, PLCB1, RPS6KA2, HRAS, MAPK3, CAMK2D",0.0535477349869269,0.00261361560268669,FALSE
+"proteomics","Log2FC","KEGG_LYSINE_DEGRADATION",-0.35898,-1.07,0.315,10138,0.61,"TMLHE, PIPOX, ALDH2, ALDH7A1, AADAT, BBOX1",0.501689446210399,0.214670164989233,FALSE
+"proteomics","Log2FC","KEGG_LYSOSOME",0.25134,0.696,0.878,1651,1,"CTSE, CTSH, AP1M2, CTSS, ACP5, LAMP3, NEU1, NPC2, NAPSA, CTSA, SLC11A2, GM2A, AP1B1, AP1S1, FUCA1, SGSH",0.0565054840938974,0,FALSE
+"proteomics","Log2FC","KEGG_MAPK_SIGNALING_PATHWAY",-0.30167,-0.882,0.566,9929,0.733,"TGFB3, DUSP16, MAPK8, FLNC, DDIT3, MKNK2, FGFR1, TGFB1, MAP2K5, PLA2G6, MAP2K6, MAPK11, MYC, NFKB2, TGFB2, ATF4, RELB, IL1A, CACNA2D2, DUSP4, CACNA2D1, MEF2C, FGF13, FGF2, RASGRP2, PDGFRA",0.247183568811729,0.134896025358872,FALSE
+"proteomics","Log2FC","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.73187,-2.12,0.00499,9747,0.382,"HNF1A, HNF4A, NEUROD1, GCK, MNX1, PAX6",2.30189945437661,0.417936637088291,FALSE
+"proteomics","Log2FC","KEGG_MELANOGENESIS",0.30698,0.863,0.626,3523,0.99,"GNAO1, TYR, CTNNB1, WNT5B, EP300, LEF1, KRAS, NRAS, WNT11, DVL1, CREBBP, CREB3L2, CREB3L1, PLCB1, HRAS, MAPK3, CAMK2D, WNT5A, TCF7L1, MAPK1, GNAI2, DVL3, GNAI3, ADCY9, CAMK2B, PLCB3, ADCY5, CREB1, PRKCG",0.20342566678957,0.00436480540245009,FALSE
+"proteomics","Log2FC","KEGG_MELANOMA",-0.43,-1.27,0.183,10540,0.57,"CDK6, FGF13, FGF2, PDGFRA",0.737548910269571,0.244125144327509,FALSE
+"proteomics","Log2FC","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42413,-1.24,0.193,10663,0.551,"AKR1C1, GSTM2, AKR1C3, AKR1C2, GSTA4, ALDH3A1, CYP3A7",0.714442690992226,0.258848401148215,FALSE
+"proteomics","Log2FC","KEGG_MISMATCH_REPAIR",0.43847,1.24,0.198,4177,0.577,"PCNA, LIG1, MLH3, RFC5, POLD4, EXO1, RFC2, RFC3, RFC1, RPA3, POLD3, RFC4",0.703334809738469,0.238824186844269,FALSE
+"proteomics","Log2FC","KEGG_MTOR_SIGNALING_PATHWAY",0.42655,1.19,0.209,2845,0.638,"VEGFA, VEGFC, PIK3CD, CAB39, PDPK1, RPS6KA1, PIK3R2, RPS6KA6, HIF1A, PIK3CA, RPS6KA2, EIF4EBP1, MAPK3, RHEB, RPS6KB2, RICTOR, RPS6KA3, MAPK1",0.679853713888946,0.195179321278838,FALSE
+"proteomics","Log2FC","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.48135,1.35,0.135,2561,0.576,"RAC2, ITGAL, ITGB2, LCK, RAET1L, ULBP2, NFATC4, SH3BP2, ICAM2, PIK3CD, RAC3, PTPN6, PPP3R1, VAV1, LCP2, PPP3CA, VAV2, IFNGR1, PPP3CB, PPP3R2, KRAS, NRAS, PTK2B, ICAM1, NFATC1, PIK3R2, RAC1, PIK3CA, HRAS, MAPK3, VAV3, GRB2, NFATC3, NFATC2, SOS2",0.869666231504994,0.239577516576788,FALSE
+"proteomics","Log2FC","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.21798,-0.626,0.934,8815,1,"TACR1, LEPR, F2R, P2RY11, CTSG, GRM5, PRSS1",0.0296531237699066,0,FALSE
+"proteomics","Log2FC","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31617,0.884,0.596,2672,1,"ARHGDIB, BCL2, TP73, PRKCD, ZNF274, MAPK12, PIK3CD, MAPK13, IRS1, GAB1, PDPK1, MAP3K5, TRAF6, KRAS, NRAS, RPS6KA4, MAP3K1, RPS6KA1, MAGED1, RHOA, PIK3R2, RPS6KA6, TP53, RAC1, NTRK2, PIK3CA, IKBKB, RPS6KA2, HRAS, MAPK3, CAMK2D, NFKBIA, GRB2, SOS2, FRS2, MAPK14, SORT1",0.224753740259764,0,FALSE
+"proteomics","Log2FC","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48857,-1.46,0.0984,9003,0.555,"NMNAT3, NAMPT, NNT, NT5C, CD38, BST1, NNMT",1.00700490156866,0.255707016877324,FALSE
+"proteomics","Log2FC","KEGG_NITROGEN_METABOLISM",-0.39831,-1.17,0.261,9727,0.569,"CA14, CA2, CA12, CPS1, CA8",0.583359492661719,0.244887733604929,FALSE
+"proteomics","Log2FC","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.43448,1.21,0.206,2883,0.611,"CASP5, CXCL1, MAPK12, TRIP6, MAPK13, CASP1, TRAF6, IL18, IKBKB, MAPK3, NAIP, NFKBIA, TAB3, MAPK14, CASP8, CCL13, MAPK1, IL1B",0.686132779630847,0.213958789757446,FALSE
+"proteomics","Log2FC","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.71762,-2.09,0.014,9253,0.224,"NHEJ1, PRKDC, RAD50, MRE11, POLL",1.85387196432176,0.649751981665837,TRUE
+"proteomics","Log2FC","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.41063,1.17,0.245,2596,0.666,"RXRA, RXRG, TGFA, ERBB2, PIK3CD, EGFR, CDK4, PDPK1, CCND1, KRAS, NRAS, PIK3R2, TP53, PIK3CA, HRAS, MAPK3, GRB2, SOS2, CDKN2A",0.610833915635468,0.176525770829699,FALSE
+"proteomics","Log2FC","KEGG_NOTCH_SIGNALING_PATHWAY",0.34018,0.949,0.481,3178,0.931,"DTX3L, EP300, JAG1, NOTCH3, NCOR2, DVL1, CREBBP, DTX2, CTBP1, NUMB, HDAC1, MAML3, DVL3, RBPJ, JAG2",0.317854923626168,0.0310503190186574,FALSE
+"proteomics","Log2FC","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.17811,-0.522,0.994,1956,0.992,"ERCC5, PCNA, RAD23B, LIG1, RFC5, POLD4, RFC2, RFC3, POLE, RFC1, RPA3, CUL4A, POLE4, POLD3, RFC4, RBX1, CETN2, POLE3, DDB1, MNAT1, POLD1, ERCC6, RAD23A, ERCC4, RPA2, POLE2, POLD2, RPA1, CDK7, GTF2H5, ERCC3, DDB2, CUL4B, GTF2H3, ERCC2, CCNH, GTF2H4, GTF2H1, GTF2H2, ERCC1, ERCC8, XPC, XPA",0.00261361560268669,0.00348832784582135,FALSE
+"proteomics","Log2FC","KEGG_N_GLYCAN_BIOSYNTHESIS",0.47511,1.32,0.126,836,0.575,"MAN1C1, MGAT4A, ST6GAL1, B4GALT1, FUT8",0.899629454882437,0.24033215531037,FALSE
+"proteomics","Log2FC","KEGG_OLFACTORY_TRANSDUCTION",-0.37643,-1.12,0.267,9870,0.536,"CNGB1, PDE1C",0.573488738635425,0.27083521030723,FALSE
+"proteomics","Log2FC","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53605,-1.57,0.0641,8075,0.565,"MTHFD1L, ATIC, MTHFD2, MTHFS, MTFMT, TYMS, MTHFR, GART, ALDH1L1",1.19314197048118,0.247951552180562,FALSE
+"proteomics","Log2FC","KEGG_OOCYTE_MEIOSIS",0.19709,0.561,0.981,3300,1,"MAPK12, PPP3R1, ANAPC11, PPP3CA, AR, AURKA, PPP3CB, PPP2R5E, CCNB1, PPP3R2, PPP2R5B, BUB1, RPS6KA1, RPS6KA6, RPS6KA2, MAPK3, CAMK2D, IGF1R, RPS6KA3, MAPK1, BTRC, YWHAB, ADCY9, PKMYT1, CAMK2B",0.0083309926200515,0,FALSE
+"proteomics","Log2FC","KEGG_OTHER_GLYCAN_DEGRADATION",-0.2091,-0.607,0.954,7256,1,"FUCA2, MAN2B1, HEXB, MAN2B2, AGA, MAN2C1, HEXA",0.0204516252959049,0,FALSE
+"proteomics","Log2FC","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.46085,-1.35,0.12,7298,0.604,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, COX15, ATP6V1A, COX4I1, SDHC, COX6B1, COX6A1, NDUFV1, UQCRC1, ATP6V1B2, COX7A2, NDUFA6, NDUFC1, PPA1, ATP6V0A2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, NDUFA11, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, ATP5MG, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, ATP5PD, NDUFB2, ATP5ME, ATP5MC2, COX11",0.920818753952375,0.218963061378868,FALSE
+"proteomics","Log2FC","KEGG_O_GLYCAN_BIOSYNTHESIS",0.59998,1.69,0.0274,1847,0.861,"GCNT3, GALNT3, GALNT12, GALNT6, ST6GALNAC1, GALNT8, GALNT13, GALNT7, B4GALT5, GALNT2, GALNT15, GALNT5, C1GALT1C1, GALNT4, ST3GAL1",1.56224943717961,0.0649968485463452,FALSE
+"proteomics","Log2FC","KEGG_P53_SIGNALING_PATHWAY",0.29693,0.833,0.667,1726,0.992,"TP73, SERPINB5, SESN3, THBS1, CHEK2, CDK4, CCND1, RCHY1, CCNB1, CDKN1A, EI24",0.175874166083451,0.00348832784582135,FALSE
+"proteomics","Log2FC","KEGG_PANCREATIC_CANCER",0.39919,1.12,0.277,2405,0.72,"RAC2, VEGFA, TGFA, ERBB2, VEGFC, PIK3CD, RAC3, EGFR, CDK4, RALB, CCND1, STAT1, KRAS, PIK3R2, TP53, JAK1, RAC1, PIK3CA, STAT3, IKBKB, MAPK3",0.557520230935551,0.142667503568732,FALSE
+"proteomics","Log2FC","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.26633,0.747,0.818,2657,1,"BCAT2, PANK1, DPYD",0.087246696328677,0,FALSE
+"proteomics","Log2FC","KEGG_PARKINSONS_DISEASE",-0.47609,-1.38,0.11,7298,0.583,"NDUFV2, COX7C, NDUFS4, SDHB, NDUFB5, UBE2J2, COX4I1, SLC18A1, SDHC, COX6B1, COX6A1, CYCS, NDUFV1, UQCRC1, COX7A2, NDUFA6, NDUFC1, UBE2G2, UBE2G1, HTRA2, NDUFA7, NDUFA8, NDUFA4, NDUFS5, PARK7, NDUFB9, NDUFB8, NDUFC2, NDUFS1, NDUFV3, NDUFB3, SLC25A6, NDUFA2, NDUFS3, ATP5F1D, ATP5PF, NDUFB4, VDAC1, NDUFA3, NDUFB7, NDUFS7, NDUFA9, ATP5F1E, ATP5PO, ATP5F1A, NDUFA5, NDUFA10, NDUFS6, SDHD, NDUFS8, NDUFS2, ATP5F1C, ATP5F1B, ATP5PB, SLC25A4, ATP5PD, NDUFB2, ATP5MC2, UCHL1",0.958607314841775,0.234331445240986,FALSE
+"proteomics","Log2FC","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.24664,0.696,0.88,646,1,"LY96, CDH1, TUBA4A, CTNNB1",0.0555173278498314,0,FALSE
+"proteomics","Log2FC","KEGG_PATHWAYS_IN_CANCER",0.24197,0.682,0.892,2654,1,"RAC2, BCL2, CDH1, PTGS2, VEGFA, CTNNA1, LAMC2, LAMB3, RXRA, RXRG, TRAF4, CTNNA2, CTNNB1, TGFA, ERBB2, WNT5B, VEGFC, PIK3CD, RAC3, EP300, MECOM, RARA, RUNX1, ITGA2, LAMA3, LAMA4, NCOA4, EGFR, CKS1B, CDK4, RALB, SKP2, AR, LEF1, CCND1, STAT1, TRAF6, KRAS, NRAS, CDKN1A, ITGA3, WNT11, DVL1, FLT3, MAX, RHOA, MMP2, BCR, CREBBP, PIK3R2, TP53, JAK1, RAC1, PIAS3, HIF1A, MET, SLC2A1, PIK3CA, CTBP1, STAT3, IKBKB, HRAS, MAPK3, LAMB1, WNT5A, NFKBIA, CBLB, GRB2, IGF1R, SOS2, CDKN2A, TCF7L1, HDAC1, PAX8",0.0496351456238769,0,FALSE
+"proteomics","Log2FC","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39564,1.11,0.295,6667,0.696,"DCXR, UGP2, XYLB, UGDH, CRYL1, UGT2B11, UGT2B4, RPE, GUSB, AKR1B1",0.530177984021837,0.157390760389438,FALSE
+"proteomics","Log2FC","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50211,1.4,0.0899,829,0.567,"ALDOB, FBP1, ALDOC, FBP2",1.04624030826677,0.246416941107093,FALSE
+"proteomics","Log2FC","KEGG_PEROXISOME",0.32858,0.939,0.513,2901,0.942,"FAR1, PXMP4, EPHX2, PEX13, MVK, ACSL4, ACOT8, ACAA1, AMACR, ACSL1, CAT, CRAT, ACOX1, SLC25A17, FAR2, SCP2, CROT, ACSL6, GSTK1, IDH2, ACOX3, ACSL5, PMVK, PEX7, NUDT12, ACSL3, ABCD3, IDH1, PXMP2",0.289882634888184,0.0259490972071227,FALSE
+"proteomics","Log2FC","KEGG_PHENYLALANINE_METABOLISM",-0.44236,-1.29,0.164,10509,0.617,"MAOB, NAA80, ALDH3A1",0.785156151952302,0.209714835966758,FALSE
+"proteomics","Log2FC","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.26615,0.753,0.807,2260,1,"IMPA2, DGKA, INPP4B, PIK3CD, PIP4K2C, CDS1, DGKH, DGKB, PIK3R2, PLCB1, PIK3C2B, PIK3CA, PI4KA, PLCD1",0.0931264652779296,0,FALSE
+"proteomics","Log2FC","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.41459,-1.24,0.195,8765,0.551,"BLVRA, HMBS, PPOX, EARS2, BLVRB, HMOX1, ALAS1, UROD, UROS, FECH",0.709965388637482,0.258848401148215,FALSE
+"proteomics","Log2FC","KEGG_PPAR_SIGNALING_PATHWAY",0.40642,1.12,0.316,1703,0.72,"CD36, PLTP, LPL, FADS2, FABP6, FABP2, RXRA, RXRG, SCD5, ACSL4, FABP3, APOC3, ACAA1, PDPK1, ACSL1, ACOX1, CPT2, SCP2, ACSL6, HMGCS2",0.500312917381596,0.142667503568732,FALSE
+"proteomics","Log2FC","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.44792,1.25,0.176,1638,0.589,"CYP7B1, AMACR, SCP2",0.75448733218585,0.229884705212898,FALSE
+"proteomics","Log2FC","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.32308,-0.948,0.459,9562,0.668,"RFX5, RFXAP, CD40, BLNK",0.338187314462739,0.175223537524454,FALSE
+"proteomics","Log2FC","KEGG_PRION_DISEASES",-0.62081,-1.83,0.0157,10295,0.396,"C7, SOD1, C9, NCAM1, IL1A, NCAM2, EGR1",1.80410034759077,0.402304814074488,FALSE
+"proteomics","Log2FC","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.25639,0.714,0.849,3263,1,"FZR1, MAPK12, PIK3CD, MAPK13, ANAPC11, CCNB1, KRAS, BUB1, CCNA2, RPS6KA1, PIK3R2, RPS6KA6, PIK3CA, RPS6KA2, MAPK3, IGF1R, MAPK14, RPS6KA3, MAPK1, GNAI2, GNAI3, CCNB3, ADCY9, PKMYT1",0.0710923097560473,0,FALSE
+"proteomics","Log2FC","KEGG_PROPANOATE_METABOLISM",-0.26044,-0.775,0.737,10443,0.881,"ALDH2, ALDH7A1, ACSS3",0.132532512140949,0.0550240915879521,FALSE
+"proteomics","Log2FC","KEGG_PROSTATE_CANCER",0.32384,0.919,0.535,2624,0.948,"BCL2, CTNNB1, TGFA, ERBB2, PIK3CD, EP300, EGFR, AR, LEF1, PDPK1, CCND1, KRAS, NRAS, CDKN1A, CREBBP, PDGFC, PIK3R2, CREB3L2, TP53, CREB3L1, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, GRB2, IGF1R, SOS2, TCF7L1",0.271646217978772,0.0231916626619338,FALSE
+"proteomics","Log2FC","KEGG_PROTEASOME",0.2805,0.797,0.729,7310,0.996,"PSMB10, PSMB8, PSME2, PSME1, POMP, PSMB1, PSMB9, PSMA7, PSMA1, PSMA2, PSME3, PSMA8, PSMA3, PSMB2, PSMC6, PSMB3, PSMD7, PSME4, PSMA5, PSMB4, PSMA4, PSMD4, PSMD2, PSMB7, PSMD3, PSMD11, PSMC2, PSMC4, PSMC3, PSMC5, PSMF1, PSMD12, PSMD13, PSMA6, PSMC1, PSMB6, PSMD14, PSMD6, PSMD8, PSMD1, SEM1",0.137272471682025,0.00174066157630127,FALSE
+"proteomics","Log2FC","KEGG_PROTEIN_EXPORT",-0.34994,-1.03,0.391,7823,0.653,"SEC61B, IMMP2L, SEC11C, SEC63, IMMP1L, SEC61A2",0.407823242604133,0.185086818724926,FALSE
+"proteomics","Log2FC","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.28081,0.793,0.739,3930,0.993,"ATP1A2, GLUD2, AQP1, SLC38A3, ATP1A3, ATP1A4, ATP1A1, SLC9A3, PCK1, ATP1B1",0.131355561605174,0.00305075150461883,FALSE
+"proteomics","Log2FC","KEGG_PURINE_METABOLISM",-0.26075,-0.758,0.763,7632,0.87,"PRIM2, PDE4D, POLA1, POLR3C, HPRT1, POLR2E, POLR3A, POLR3H, PDE8A, ENTPD4, GMPR2, POLA2, POLR2H, NUDT9, PNPT1, ATIC, NME2, ADCY3, ADCY8, PAPSS2, AK5, NUDT2, POLR3GL, GDA, POLR1E, GMPS, RRM2B, ADCY10, NPR2, GART, PFAS, NT5C, NME4, NUDT5, PDE3A, ADCY6, ENTPD1, PDE4A, NME1, NPR1, PDE1C, ENTPD8",0.11747546204512,0.0604807473813815,FALSE
+"proteomics","Log2FC","KEGG_PYRIMIDINE_METABOLISM",-0.20888,-0.598,0.967,7564,0.993,"POLR2A, AK3, PRIM2, DHODH, DCTD, POLA1, POLR3C, POLR2E, POLR3A, POLR3H, ENTPD4, POLA2, POLR2H, PNPT1, NME2, DTYMK, NUDT2, TYMS, POLR3GL, POLR1E, CAD, RRM2B, DUT, UCK2, NT5C, UMPS, NME4, TXNRD1, ENTPD1, CTPS1, NME1, ENTPD8",0.0145735259169983,0.00305075150461883,FALSE
+"proteomics","Log2FC","KEGG_PYRUVATE_METABOLISM",-0.33889,-0.988,0.412,7380,0.677,"ACYP2, GRHPR, ACACA, PDHB, ALDH9A1, ME2, ALDH1B1, PDHA1, ACAT1, ALDH3A2, GLO1, PCK2, HAGH, ME3, ALDH2, ALDH7A1",0.385102783966865,0.169411331314856,FALSE
+"proteomics","Log2FC","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.26341,0.759,0.781,1559,1,"ITGB6, RAC2, ITGAL, PAK5, PAK6, ITGB8, ITGB2, ACTN3, ITGB4, BAIAP2, SCIN, MYH14, PIK3CD, PIP4K2C, SLC9A1, RAC3, VAV1, GSN, ITGA2, ITGA11, EGFR, SSH3, VAV2, FGD3, ITGA4, KRAS, NRAS",0.1073489661227,0,FALSE
+"proteomics","Log2FC","KEGG_REGULATION_OF_AUTOPHAGY",-0.43145,-1.27,0.193,7210,0.57,"PIK3R4, ATG4B, ULK1, ATG5, PIK3C3, GABARAPL1, ATG3, ATG7, ULK3, PRKAA2",0.714442690992226,0.244125144327509,FALSE
+"proteomics","Log2FC","KEGG_RENAL_CELL_CARCINOMA",0.3892,1.1,0.311,2561,0.704,"PAK5, PAK6, VEGFA, TGFA, VEGFC, PIK3CD, EP300, GAB1, KRAS, NRAS, CREBBP, PIK3R2, RAC1, HIF1A, MET, SLC2A1, PIK3CA, HRAS, MAPK3, GRB2, SOS2",0.507239610973163,0.152427340857888,FALSE
+"proteomics","Log2FC","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.32703,-0.955,0.44,9197,0.682,"NLN, AGT, CTSG, ACE2",0.356547323513813,0.166215625343521,FALSE
+"proteomics","Log2FC","KEGG_RETINOL_METABOLISM",-0.40251,-1.16,0.248,10576,0.551,"ALDH1A2, ALDH1A1, CYP3A7",0.605548319173784,0.258848401148215,FALSE
+"proteomics","Log2FC","KEGG_RIBOFLAVIN_METABOLISM",0.46483,1.31,0.152,593,0.537,"ACP5, MTMR7, TYR",0.818156412055227,0.270025714300444,FALSE
+"proteomics","Log2FC","KEGG_RIBOSOME",-0.54955,-1.56,0.092,6763,0.519,"RPSA, RPS16, RPS26, MRPL13, RPL13, RPL11, RPS25, RPL37A, RPL35, RPS4X, RPL27, RPS21, RPS28, RPS27L, RPS15A, RPS2, RPL14, FAU, RPL23, RPL7A, RPL29, RPS29, RPL21, RPL5, RPL34, RPL22, RPS9, RPS3, RPS18, RPL17, RPL15, RPL8, RPL18A, RPS3A, RPS12, RPL28, RPS11, RPL36, RPS17, RPL36A, RPL36AL, RPL3, RPL13A, RPL32, RPL26, RPL27A, RPS8, RPL10A, RPS7, RPS24, RPL7, RPS23, RPL31, RPL9, RPS13, RPL35A, RPL18, RPL19, RPL24, RSL24D1, RPL4, RPS20, RPL6, RPL38, RPS6, RPL37, RPL26L1, RPS4Y1",1.03621217265444,0.284832642151542,FALSE
+"proteomics","Log2FC","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21434,0.603,0.954,1713,1,"ISG15, MAPK12, MAPK13, CASP10, DDX58, DHX58, TRAF6, MAP3K1",0.0204516252959049,0,FALSE
+"proteomics","Log2FC","KEGG_RNA_DEGRADATION",-0.43669,-1.26,0.18,7190,0.562,"TTC37, EXOSC3, EXOSC2, EXOSC4, DIS3, EXOSC9, EXOSC5, EXOSC7, LSM2, PNPT1, EXOSC10, EXOSC8, LSM1, EXOSC1, MTREX, ENO3, HSPD1, HSPA9, PARN, TENT4A, DCP2, MPHOSPH6, DCPS, DCP1B",0.744727494896694,0.250263684430939,FALSE
+"proteomics","Log2FC","KEGG_RNA_POLYMERASE",-0.42301,-1.21,0.209,5911,0.538,"POLR3F, POLR1B, POLR2D, POLR3K, POLR2B, POLR2G, POLR2C, POLR1A, POLR3B, POLR1C, POLR1D, POLR3D, POLR2L, POLR2I, POLR2A, POLR3C, POLR2E, POLR3A, POLR3H, POLR2H, POLR3GL, POLR1E",0.679853713888946,0.269217724333611,FALSE
+"proteomics","Log2FC","KEGG_SELENOAMINO_ACID_METABOLISM",0.26182,0.74,0.808,2085,1,"GGT5, CTH, METTL6, GGT7",0.0925886392254138,0,FALSE
+"proteomics","Log2FC","KEGG_SMALL_CELL_LUNG_CANCER",0.31583,0.876,0.609,2488,0.986,"BCL2, PTGS2, LAMC2, LAMB3, RXRA, RXRG, TRAF4, PIK3CD, ITGA2, LAMA3, LAMA4, CKS1B, CDK4, SKP2, CCND1, TRAF6, ITGA3, MAX, PIK3R2, TP53, PIAS3, PIK3CA, IKBKB, LAMB1, NFKBIA",0.215382707367125,0.0061230850587888,FALSE
+"proteomics","Log2FC","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.25505,0.72,0.836,3653,1,"VAMP8, VAMP4, TSNARE1, BET1L, STX17, SNAP47, STX3, GOSR1, STX10, SNAP29, STX16, STX18, STX12, STX6, VTI1B, SNAP23",0.0777937225609836,0,FALSE
+"proteomics","Log2FC","KEGG_SPHINGOLIPID_METABOLISM",0.29469,0.833,0.682,2465,0.992,"CERK, NEU1, UGT8, SGPP2, SPTLC2, GALC, PLPP3, DEGS1, SPTLC1",0.166215625343521,0.00348832784582135,FALSE
+"proteomics","Log2FC","KEGG_SPLICEOSOME",-0.44795,-1.31,0.152,6622,0.608,"BCAS2, SNRPD1, SNRPD2, USP39, SF3A2, PRPF6, LSM3, THOC2, SNW1, SRSF6, SYF2, PQBP1, HNRNPA1, U2AF2, ACIN1, SNRPB2, MAGOHB, SRSF7, PRPF40A, HSPA8, HNRNPC, SNRPC, PPIL1, THOC1, RBM25, CTNNBL1, ZMAT2, SNRNP200, PRPF38B, HNRNPK, PRPF31, PPIH, HNRNPM, EIF4A3, DDX46, DDX39B, HNRNPA3, SF3A3, SRSF9, U2AF1, SRSF1, DDX23, SRSF4, SNRPA, SNRNP27, EFTUD2, SRSF8, PRPF38A, TRA2B, SNRPD3, DHX16, PPIE, SNRPF, SRSF3, LSM2, ALYREF, RBM8A, RBM17, SRSF2, SF3B4, TCERG1, RBMX, PRPF8, CDC40, U2SURP, SMNDC1, WBP11, RBM22, SNRNP40, SLU7, PRPF18, TRA2A, BUD31, SNU13, TXNL4A, CHERP, HNRNPU",0.818156412055227,0.216096420727265,FALSE
+"proteomics","Log2FC","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.44846,1.26,0.169,2989,0.586,"HK1, SI, PYGB, PGM1, HK2, GAA, PGM2, AGL, PYGL, GYS1, UGP2, MGAM, PGM2L1",0.772113295386326,0.232102383981909,FALSE
+"proteomics","Log2FC","KEGG_STEROID_BIOSYNTHESIS",0.72045,2,0.00945,2290,0.637,"DHCR24, MSMO1, FDFT1, CYP27B1, DHCR7, SC5D, SQLE, NSDHL, HSD17B7, CYP51A1, LSS",2.02456819149074,0.19586056766465,FALSE
+"proteomics","Log2FC","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44063,-1.31,0.152,10468,0.608,"AKR1D1, CYP21A2, AKR1C1, AKR1C3, AKR1C2, CYP3A7",0.818156412055227,0.216096420727265,FALSE
+"proteomics","Log2FC","KEGG_SULFUR_METABOLISM",0.57977,1.63,0.0388,1903,0.638,"SULT2B1, SULT1A3, CHST12",1.41116827440579,0.195179321278838,FALSE
+"proteomics","Log2FC","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.47545,-1.42,0.0956,9770,0.588,"CTSG, C7, CD40, C9, C1S",1.0195421077239,0.230622673923862,FALSE
+"proteomics","Log2FC","KEGG_TASTE_TRANSDUCTION",0.39951,1.12,0.276,89,0.72,"SCNN1A",0.559090917934782,0.142667503568732,FALSE
+"proteomics","Log2FC","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.5101,1.42,0.0899,2497,0.658,"HMGCS1, MVK, HMGCR, HMGCS2, PDSS2, PMVK, FDPS",1.04624030826677,0.181774106386044,FALSE
+"proteomics","Log2FC","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.42677,-1.23,0.218,9929,0.525,"TGFB3, THBS4, THBS3, TGFB1, SMAD2, BMPR2, MYC, INHBA, FST, ACVR2A, TGFB2, BMPR1A, INHBE",0.661543506395395,0.279840696594043,FALSE
+"proteomics","Log2FC","KEGG_THYROID_CANCER",0.56509,1.59,0.0464,2845,0.481,"CDH1, RXRA, RXRG, CTNNB1, NCOA4, LEF1, CCND1, KRAS, NRAS, TP53, HRAS, MAPK3, TCF7L1, PAX8, MAPK1",1.33348201944512,0.317854923626168,FALSE
+"proteomics","Log2FC","KEGG_TIGHT_JUNCTION",0.5679,1.62,0.0411,1947,0.583,"CLDN18, CLDN4, CLDN7, CRB3, MYH7, PRKCH, EPB41L1, CGN, CLDN3, F11R, CLDN6, TJP3, ACTN3, CTNNA1, PRKCD, JAM2, PATJ, CTNNA2, CTNNB1, MYH14, MYH7B, TJP2, LLGL2, CDK4, MAGI3, PRKCQ, CASK, KRAS, NRAS, PRKCZ, PRKCI, CTTN, PARD6G, YES1, CLDN11, EXOC3, MYL9, RHOA, EXOC4",1.38615817812393,0.234331445240986,FALSE
+"proteomics","Log2FC","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.24732,0.69,0.873,2883,1,"LY96, IRF5, MAPK12, PIK3CD, MAPK13, MYD88, STAT1, TRAF6, PIK3R2, RAC1, PIK3CA, IKBKB, MAPK3, NFKBIA, IKBKE, MAPK14, CASP8, MAPK1, IL1B",0.0589857562944303,0,FALSE
+"proteomics","Log2FC","KEGG_TRYPTOPHAN_METABOLISM",-0.38666,-1.12,0.273,10040,0.536,"WARS2, ALDH2, MAOB, ALDH7A1, AADAT, KYNU",0.563837352959244,0.27083521030723,FALSE
+"proteomics","Log2FC","KEGG_TYPE_II_DIABETES_MELLITUS",-0.31589,-0.922,0.531,10063,0.706,"MAPK8, GCK, SOCS2, SOCS4",0.274905478918531,0.151195298948196,FALSE
+"proteomics","Log2FC","KEGG_TYPE_I_DIABETES_MELLITUS",0.44767,1.26,0.167,1073,0.586,"CPE, PTPRN2, ICA1",0.777283528852417,0.232102383981909,FALSE
+"proteomics","Log2FC","KEGG_TYROSINE_METABOLISM",0.29251,0.819,0.688,2304,0.986,"ADH4, ADH7, TYR, HGD, ALDH1A3, ALDH3B1, METTL6, ADH1C, COMT, TAT, MIF",0.162411561764489,0.0061230850587888,FALSE
+"proteomics","Log2FC","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.50774,1.4,0.108,2664,0.567,"PAK5, PAK6, LCK, CARD11, MAPK12, NFATC4, PIK3CD, MAPK13, PTPN6, PPP3R1, VAV1, LCP2, CDK4, PPP3CA, VAV2, PDPK1, PPP3CB, PPP3R2, PRKCQ, KRAS, NRAS, RHOA, NFATC1, PTPRC, PIK3R2, PIK3CA, IKBKB, HRAS, MAPK3, NFKBIA, CBLB, VAV3, GRB2, NFATC3, NFATC2, SOS2, TEC, MAPK14",0.96657624451305,0.246416941107093,FALSE
+"proteomics","Log2FC","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18021,0.513,0.99,2223,1,"FZR1, UBE2C, UBA7, UBE2E3, ANAPC11, TRIM37, SKP2, RCHY1, MGRN1, UBOX5, UBE2L6, KEAP1, TRAF6, MAP3K1, UBE2O, ITCH, UBA6, PIAS3, BRCA1",0.00436480540245009,0,FALSE
+"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.33808,-0.967,0.452,7753,0.673,"PDHB, PDHA1, LARS2, BCAT1",0.344861565188618,0.171984935776023,FALSE
+"proteomics","Log2FC","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.25067,0.696,0.885,2361,1,"ABAT, HMGCS1, ALDH6A1, ACAD8, ACAA1, BCAT2, HMGCS2, MCCC1, HIBADH, ACADM, DBT, ACADS",0.0530567293021746,0,FALSE
+"proteomics","Log2FC","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.285,-0.832,0.653,9514,0.793,"NPR2, ITPR1, PLCB2, ARHGEF11, ARHGEF1, PLCB4, PLA2G6, ADCY6, NPR1, CALD1, KCNMA1, PPP1R14A",0.185086818724926,0.100726812682396,FALSE
+"proteomics","Log2FC","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.2868,0.789,0.715,2159,0.989,"ARHGDIB, AQP3, DYNLL2, RAB11B, CREB3L2, CREB3L1, RAB11A",0.145693958198919,0.0048037084028206,FALSE
+"proteomics","Log2FC","KEGG_VEGF_SIGNALING_PATHWAY",0.53564,1.52,0.0683,2664,0.544,"RAC2, PTGS2, VEGFA, HSPB1, MAPK12, NOS3, NFATC4, PIK3CD, MAPK13, PLA2G12A, RAC3, PPP3R1, PPP3CA, PLA2G2A, PPP3CB, PPP3R2, KRAS, NRAS, NFATC1, PIK3R2, MAPKAPK3, RAC1, PIK3CA, HRAS, MAPK3, NFATC3, NFATC2, MAPK14",1.16557929631847,0.26440110030182,FALSE
+"proteomics","Log2FC","KEGG_VIBRIO_CHOLERAE_INFECTION",0.14569,0.411,0.998,1695,1,"TJP2, ERO1A, PDIA4, KDELR3",0.000869458712628891,0,FALSE
+"proteomics","Log2FC","KEGG_VIRAL_MYOCARDITIS",0.40292,1.11,0.283,1355,0.696,"RAC2, MYH7, ITGAL, ITGB2, MYH14, MYH7B, RAC3, SGCG, CCND1",0.54821356447571,0.157390760389438,FALSE
+"proteomics","Log2FC","KEGG_WNT_SIGNALING_PATHWAY",0.29792,0.819,0.669,2624,0.986,"RAC2, VANGL2, SFRP4, CTNNB1, NFATC4, WNT5B, DAAM1, RAC3, EP300, PPP3R1, CSNK1A1, TBL1XR1, PPP3CA, LEF1, CCND1, PPP3CB, PPP2R5E, PPP3R2, LRP5, PPP2R5B, SENP2, DKK1, WNT11, DVL1, RHOA, NFATC1, CREBBP, TP53, PLCB1, RAC1, CHD8, CTBP1, CSNK1E, CAMK2D, WNT5A, NFATC3, NFATC2, TCF7L1",0.174573882232177,0.0061230850587888,FALSE
+"metabolomics","Log2FC","alpha amino acids",-0.62759,-1.44,0.0866,172,0.18,"sarcosine, phosphocreatine, creatinine, dimethylglycine, citrulline, ornithine, homocysteine",1.06248210798265,0.744727494896694,FALSE
+"metabolomics","Log2FC","acyl carnitines",-0.61528,-1.38,0.119,202,0.123,"hexanoylcarnitine, malonylcarnitine, propionylcarnitine",0.924453038607469,0.910094888560602,FALSE
diff --git a/Examples/Fig5/GSEA/GSEA_venn_diagram.pdf b/Examples/Fig5/GSEA/GSEA_venn_diagram.pdf
new file mode 100644
index 0000000..3bfb300
Binary files /dev/null and b/Examples/Fig5/GSEA/GSEA_venn_diagram.pdf differ
diff --git a/Examples/GSE12790_transcriptomics_DEGs.csv b/Examples/GSE12790_transcriptomics_DEGs.csv
new file mode 100644
index 0000000..aeca2ca
--- /dev/null
+++ b/Examples/GSE12790_transcriptomics_DEGs.csv
@@ -0,0 +1,22190 @@
+"Gene","Log2FC"
+"A1BG",0.122732803330086
+"A1BG-AS1",-0.692704038428339
+"A1CF",-0.386461227542601
+"A2M",-0.54948569347626
+"A2M-AS1",0.403523074957423
+"A2ML1",1.26309682948224
+"A2MP1",0.545545625388718
+"A4GALT",0.421692150170746
+"A4GNT",-0.105567393349095
+"AA06",0.66550063427909
+"AAAS",-0.384561984277299
+"AACS",0.0246537128123574
+"AACSP1",0.881019238788899
+"AADAC",2.61424622282599
+"AADACL2",0.659370076908572
+"AADACP1",3.54360590573153
+"AADAT",0.122265458293263
+"AAED1",0.379332739670714
+"AAGAB",-1.00847225233325
+"AAK1",0.541328996655275
+"AAMDC",0.177690604705538
+"AAMP",-0.303650958206463
+"AANAT",-0.483847429407829
+"AAR2",-0.384675602739254
+"AARS",-0.169137409174153
+"AARS2",-0.80415885317762
+"AASDH",-0.0878097448800777
+"AASDHPPT",0.158796492989218
+"AASS",1.41206866488668
+"AATBC",0.121779612251081
+"AATF",0.202456788593771
+"AATK",-0.33702395276199
+"ABAT",-0.812802669208704
+"ABCA1",0.395173408475789
+"ABCA11P",-0.199147854606596
+"ABCA12",-0.508228406018635
+"ABCA13",0.785324926272938
+"ABCA17P",-2.1568278981667
+"ABCA2",-1.26362021996951
+"ABCA3",-1.92320903680023
+"ABCA4",0.0901405978284667
+"ABCA5",0.410741138763597
+"ABCA6",0.641722219014825
+"ABCA7",0.121721580849258
+"ABCA8",-0.15224439055991
+"ABCA9",-0.332652952838834
+"ABCB1",0.494084033274754
+"ABCB10",0.3639431747707
+"ABCB11",-0.23600429283258
+"ABCB4",-0.454830309434571
+"ABCB4///ABCB1",0.504758930003886
+"ABCB5",0.426661489452238
+"ABCB6",-0.486621816503433
+"ABCB7",0.0516740596080005
+"ABCB8",0.0238633968489145
+"ABCB8///ASIC3",-0.182081464590243
+"ABCB9",-0.208970121419657
+"ABCC1",0.171566504169566
+"ABCC10",0.483283224764055
+"ABCC11",-2.04670259085808
+"ABCC12",0.10367435807426
+"ABCC13",0.333691809487528
+"ABCC2",-0.0862276012706431
+"ABCC3",1.49752680403942
+"ABCC4",-0.128370856458532
+"ABCC5",-0.2944435208554
+"ABCC6P1",-0.648290454669469
+"ABCC8",-0.17651876098752
+"ABCC9",0.410705932481339
+"ABCD1",-0.593371160052937
+"ABCD2",-1.19325698627995
+"ABCD3",-0.00542417587441599
+"ABCD4",0.143593227565669
+"ABCE1",0.169557662404855
+"ABCF1",0.23105926773443
+"ABCF2",-0.562222495728051
+"ABCF3",-0.0223522722969705
+"ABCG1",-1.09961107566201
+"ABCG2",1.84097821117792
+"ABCG4",0.381342753960824
+"ABCG5",-0.251208130756071
+"ABCG8",0.821912221227206
+"ABHD1",-0.178085727074365
+"ABHD10",0.259194125704742
+"ABHD11",-1.13668283288854
+"ABHD12",-0.7897202182055
+"ABHD13",0.366140494519528
+"ABHD14A-ACY1///ACY1",-0.153282270192431
+"ABHD14A///ACY1",0.175979918299568
+"ABHD14B",0.0882658010789132
+"ABHD15",0.109582189745812
+"ABHD16A",0.281018164612724
+"ABHD16B",0.215989246437606
+"ABHD17A",-0.37937523458702
+"ABHD17B",-0.109263492452367
+"ABHD17C",0.273303299650346
+"ABHD18",-0.427794893700846
+"ABHD2",-0.311158750300206
+"ABHD3",0.880766172225519
+"ABHD4",-0.222193189267175
+"ABHD5",-0.15961175312342
+"ABHD6",0.104719823657715
+"ABHD8",0.231301950256859
+"ABI1",-0.247256640863837
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+"ZSCAN31",0.772973388075962
+"ZSCAN32",-0.473629847386941
+"ZSCAN4",0.65105915999212
+"ZSCAN5A",0.672403912692624
+"ZSCAN9",0.378704926348453
+"ZSWIM1",-0.31240353886627
+"ZSWIM2",0.374718538790971
+"ZSWIM3",-0.0937720489861409
+"ZSWIM4",0.427364445890984
+"ZSWIM5",-0.889115572700979
+"ZSWIM6",0.358424628692351
+"ZSWIM7",0.535444401963346
+"ZSWIM8",-0.06741109676555
+"ZSWIM8-AS1///NDST2",-0.00261187823887798
+"ZSWIM8///SAT1",0.301724614729852
+"ZUFSP",-0.090981144713016
+"ZW10",0.164318368273326
+"ZWILCH",-0.077314616253899
+"ZWINT",-0.167437710628288
+"ZXDA",-0.651070918230173
+"ZXDB",0.065332460905166
+"ZXDB///ZXDA",-0.103257579350355
+"ZXDC",-0.20724853775783
+"ZYG11A",0.702541544874086
+"ZYG11B",-0.333907885995411
+"ZYX",0.331449135030011
+"ZZEF1",0.202633802369277
+"ZZZ3",0.194529535579423
diff --git a/Examples/GSE12790_transcriptomics_DEGs_before_avg.csv b/Examples/GSE12790_transcriptomics_DEGs_before_avg.csv
new file mode 100644
index 0000000..06b68cf
--- /dev/null
+++ b/Examples/GSE12790_transcriptomics_DEGs_before_avg.csv
@@ -0,0 +1,45119 @@
+"ID","adj.P.Val","P.Value","t","B","Log2FC","Gene","Gene.title","Log2Transformed"
+"229819_at",0.97304633500821,0.869100467512382,0.166722621151938,-5.926153925028,0.122732803330086,"A1BG","alpha-1-B glycoprotein",TRUE
+"232462_s_at",0.83582292781588,0.415213288384218,-0.830323923416695,-5.60934951084457,-0.692704038428339,"A1BG-AS1","A1BG antisense RNA 1",TRUE
+"241547_at",0.771011793494937,0.279887166068968,-1.10766401995847,-5.35913673570321,-1.02936211455899,"A1CF","APOBEC1 complementation factor",TRUE
+"220951_s_at",0.821424121108148,0.382966200755163,0.890117499663981,-5.56097565939661,0.256439659473787,"A1CF","APOBEC1 complementation factor",TRUE
+"1558450_at",0.768852835478002,0.273757538410662,1.12228222342716,-5.34416017243105,0.361547950046539,"A2M","alpha-2-macroglobulin",TRUE
+"217757_at",0.778800606399021,0.299750049584398,-1.06183028756695,-5.40495964993166,-1.46051933699906,"A2M","alpha-2-macroglobulin",TRUE
+"1564139_at",0.903021267024792,0.602901078875887,0.527775510938369,-5.80491665120302,0.403523074957423,"A2M-AS1","A2M antisense RNA 1 (head to head)",TRUE
+"1564307_a_at",0.250356179889913,0.00351900731628022,3.26527238115836,-1.76350474102685,1.89333628572355,"A2ML1","alpha-2-macroglobulin like 1",TRUE
+"1553505_at",0.581813873328156,0.0640118976679141,1.94944208274185,-4.24094719892669,0.632857373240935,"A2ML1","alpha-2-macroglobulin like 1",TRUE
+"236394_at",0.778665768282906,0.299132982112742,1.06322085571492,-5.40359486970143,0.545545625388718,"A2MP1","alpha-2-macroglobulin pseudogene 1",TRUE
+"219488_at",0.879447209955825,0.533931134661014,0.631880419200557,-5.74706137258154,0.421692150170746,"A4GALT","alpha 1,4-galactosyltransferase",TRUE
+"221131_at",0.952669452014258,0.783271145430214,-0.278420876029311,-5.901997600988,-0.105567393349095,"A4GNT","alpha-1,4-N-acetylglucosaminyltransferase",TRUE
+"241552_at",0.73223722457785,0.216068363804473,1.27341653672008,-5.17929863256839,0.66550063427909,"AA06","uncharacterized LOC100506677",TRUE
+"218075_at",0.750592200257741,0.243526336366187,-1.19812911851695,-5.26368555491926,-0.384561984277299,"AAAS","aladin WD repeat nucleoporin",TRUE
+"218434_s_at",0.990810941805126,0.955045773491401,0.0570131282738937,-5.93810040761232,0.0246537128123574,"AACS","acetoacetyl-CoA synthetase",TRUE
+"1570020_at",0.714464781302461,0.189400137909426,1.35395722473797,-5.08418829855278,0.881019238788899,"AACSP1","acetoacetyl-CoA synthetase pseudogene 1",TRUE
+"205969_at",0.192886797730178,0.00197208449805523,3.50756074914058,-1.25485820452536,2.61424622282599,"AADAC","arylacetamide deacetylase",TRUE
+"240420_at",0.859465912277024,0.476817847212852,0.723706615982682,-5.68775339159044,0.659370076908572,"AADACL2","arylacetamide deacetylase like 2",TRUE
+"1569582_at",0.0723378272955723,0.000226989642328598,4.39433117165236,0.651062805612588,3.54360590573153,"AADACP1","arylacetamide deacetylase pseudogene 1",TRUE
+"223593_at",0.974982245454858,0.878458858923303,0.154699407486445,-5.928033849287,0.122265458293263,"AADAT","aminoadipate aminotransferase",TRUE
+"227534_at",0.895758940460776,0.576452227591224,0.566942729358551,-5.78433071451621,0.379332739670714,"AAED1","AhpC/TSA antioxidant enzyme domain containing 1",TRUE
+"202851_at",0.0823353801878483,0.000302686994380567,-4.2769452368367,0.397470559876801,-2.54208457418215,"AAGAB","alpha- and gamma-adaptin binding protein",TRUE
+"202852_s_at",0.62524538993269,0.0965861048475205,-1.73525285706588,-4.57071901350373,-0.717157417556637,"AAGAB","alpha- and gamma-adaptin binding protein",TRUE
+"243284_at",0.885029460971826,0.546104049836424,0.613021072156543,-5.75828674635516,0.233825234739036,"AAGAB","alpha- and gamma-adaptin binding protein",TRUE
+"225522_at",0.502830732454795,0.032528802939051,2.28080534146558,-3.68107282732954,0.956479185679589,"AAK1","AP2 associated kinase 1",TRUE
+"205434_s_at",0.520046545647116,0.0376549335757491,2.21100888623544,-3.80355778256122,1.29832231881854,"AAK1","AP2 associated kinase 1",TRUE
+"214956_at",0.663789119801086,0.131724757715407,1.56512669754899,-4.81218226172725,1.15795528953092,"AAK1","AP2 associated kinase 1",TRUE
+"214998_at",0.67368843181164,0.140268701622733,-1.52959868841126,-4.86015911536729,-0.86842494003225,"AAK1","AP2 associated kinase 1",TRUE
+"211186_s_at",0.773754791548713,0.285387089645566,1.09474423255899,-5.37222808366634,0.376219641904533,"AAK1","AP2 associated kinase 1",TRUE
+"205435_s_at",0.800179799309599,0.33585679952587,0.983755775289176,-5.47899811842713,0.327545277102224,"AAK1","AP2 associated kinase 1",TRUE
+"238100_at",0.8552783609358,0.467669877257759,0.738990391741017,-5.67713892897614,0.541206203583369,"AAK1","AP2 associated kinase 1",TRUE
+"220268_at",0.898745710465686,0.588561319857776,0.548903156520057,-5.7939899080502,0.444053792750353,"AAMDC","adipogenesis associated Mth938 domain containing",TRUE
+"221600_s_at",0.931370027472813,0.69643135375812,0.395259174995785,-5.86387485078111,0.154782357484136,"AAMDC","adipogenesis associated Mth938 domain containing",TRUE
+"221599_at",0.976392182310915,0.887543734644594,-0.143049902300396,-5.92972148638829,-0.0657643361178746,"AAMDC","adipogenesis associated Mth938 domain containing",TRUE
+"201511_at",0.797287748779547,0.33043512368257,-0.995092732372041,-5.46856497287621,-0.303650958206463,"AAMP","angio associated migratory cell protein",TRUE
+"207225_at",0.780216511409289,0.301586626910319,-1.05770357380254,-5.40900040633915,-0.483847429407829,"AANAT","aralkylamine N-acetyltransferase",TRUE
+"218089_at",0.740476003158683,0.22947107312519,-1.23581162714828,-5.22200240000138,-0.384675602739254,"AAR2","AAR2 splicing factor homolog",TRUE
+"201000_at",0.914776697425609,0.64102130056639,-0.472741407346357,-5.83141477949338,-0.169137409174153,"AARS","alanyl-tRNA synthetase",TRUE
+"230024_at",0.700061364939874,0.171900461451074,-1.41179562844742,-5.01288532841945,-1.17246073893908,"AARS2","alanyl-tRNA synthetase 2, mitochondrial",TRUE
+"231845_at",0.759352376881856,0.25690901266686,-1.16373912177647,-5.30074549408423,-0.435856967416159,"AARS2","alanyl-tRNA synthetase 2, mitochondrial",TRUE
+"228041_at",0.866602763987519,0.49777434541817,-0.689325960554246,-5.71085839089795,-0.177611181866107,"AASDH","aminoadipate-semialdehyde dehydrogenase",TRUE
+"235435_at",0.998870448604467,0.995551026867797,0.00563924157314483,-5.93966799164419,0.00199169210595151,"AASDH","aminoadipate-semialdehyde dehydrogenase",TRUE
+"202170_s_at",0.871451481476429,0.512409553655032,0.665803217080927,-5.72604754247521,0.245297624263582,"AASDHPPT","aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase",TRUE
+"202169_s_at",0.929234395612144,0.688978011309925,0.405529009225671,-5.85989999526046,0.135830842712618,"AASDHPPT","aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase",TRUE
+"224313_at",0.974435013896831,0.874867285344288,0.159310830452186,-5.92732940252209,0.0952610119914543,"AASDHPPT","aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase",TRUE
+"210852_s_at",0.529740674725706,0.0413619193489536,2.16573549027447,-3.88176703994004,2.25735064249379,"AASS","aminoadipate-semialdehyde synthase",TRUE
+"214829_at",0.931582451098271,0.697629633349212,0.39361214413364,-5.86450297735279,0.566786687279562,"AASS","aminoadipate-semialdehyde synthase",TRUE
+"1563088_a_at",0.957610494018084,0.80984628234677,0.243515873489967,-5.91084184928419,0.121779612251081,"AATBC","apoptosis associated transcript in bladder cancer",TRUE
+"209165_at",0.885029460971826,0.545555614509765,0.613865903761208,-5.75779090245723,0.202456788593771,"AATF","apoptosis antagonizing transcription factor",TRUE
+"205986_at",0.877371513533639,0.527289447886636,-0.642267998164302,-5.74073877406474,-0.33702395276199,"AATK","apoptosis associated tyrosine kinase",TRUE
+"206527_at",0.816800680706682,0.368011572034371,-0.91896288924864,-5.53652565273098,-0.614539083754122,"ABAT","4-aminobutyrate aminotransferase",TRUE
+"209459_s_at",0.899998627338565,0.594305607755395,-0.540409922222545,-5.79843253448719,-0.991598516625908,"ABAT","4-aminobutyrate aminotransferase",TRUE
+"209460_at",0.920780424288498,0.663109115338341,-0.44152888897838,-5.84517510251742,-0.832270407246082,"ABAT","4-aminobutyrate aminotransferase",TRUE
+"216066_at",0.762510938865139,0.262005743513499,1.15099207491012,-5.31424202666551,0.675262794993785,"ABCA1","ATP binding cassette subfamily A member 1",TRUE
+"1570279_at",0.794620886196317,0.32659194478877,1.00320711236549,-5.46103082849333,0.850427953709427,"ABCA1","ATP binding cassette subfamily A member 1",TRUE
+"203505_at",0.994875434900261,0.975983042892896,0.0304471478797722,-5.93923196927996,0.0382241886482735,"ABCA1","ATP binding cassette subfamily A member 1",TRUE
+"203504_s_at",0.996555192440456,0.982844229884918,0.0217472579117502,-5.93945313016599,0.0167786965516719,"ABCA1","ATP binding cassette subfamily A member 1",TRUE
+"220159_at",0.914862008781588,0.641315339928156,-0.472322821315202,-5.83160540426917,-0.199147854606596,"ABCA11P","ATP binding cassette subfamily A member 11, pseudogene",TRUE
+"215465_at",0.95238233774064,0.782101837259197,-0.27996451856959,-5.90157934992021,-0.508228406018635,"ABCA12","ATP binding cassette subfamily A member 12",TRUE
+"1553604_at",0.606032418428309,0.0795297708743353,1.83786218920498,-4.41615716878695,2.44014263385165,"ABCA13","ATP binding cassette subfamily A member 13",TRUE
+"1553295_at",0.85334340854827,0.460340387060621,0.75136415220827,-5.66839136909334,0.675576299149788,"ABCA13","ATP binding cassette subfamily A member 13",TRUE
+"1553605_a_at",0.913160385122315,0.635584410079819,-0.480496771374773,-5.82785308908372,-0.759744154182623,"ABCA13","ATP binding cassette subfamily A member 13",TRUE
+"231164_at",0.407748633394319,0.0155378596392979,-2.62129329853669,-3.05359043713003,-2.1568278981667,"ABCA17P","ATP binding cassette subfamily A member 17, pseudogene",TRUE
+"212772_s_at",0.332429060350567,0.00811928080885751,-2.90784497193983,-2.493229693317,-1.12715782732339,"ABCA2","ATP binding cassette subfamily A member 2",TRUE
+"210100_s_at",0.39149295959037,0.0132753168190315,-2.69168641031981,-2.91836366461265,-2.40790840907768,"ABCA2","ATP binding cassette subfamily A member 2",TRUE
+"210099_at",0.847527520228882,0.446356172989318,-0.775304427950091,-5.65107696180715,-0.255794423507448,"ABCA2","ATP binding cassette subfamily A member 2",TRUE
+"204343_at",0.534566721281704,0.0425013541364713,-2.1525575927107,-3.90434308438057,-1.92320903680023,"ABCA3","ATP binding cassette subfamily A member 3",TRUE
+"210082_at",0.961539013416204,0.825626685170731,0.222937373870023,-5.91550487241995,0.239894011337592,"ABCA4","ATP binding cassette subfamily A member 4",TRUE
+"1569102_at",0.982909728377256,0.917061665630063,-0.10533005961592,-5.93428124140402,-0.0596128156806586,"ABCA4","ATP binding cassette subfamily A member 4",TRUE
+"241705_at",0.864079461576774,0.491225054288104,0.699979408651407,-5.70381350892307,0.65703886516065,"ABCA5","ATP binding cassette subfamily A member 5",TRUE
+"213353_at",0.965707350334601,0.839814147339659,0.204520089664131,-5.91933088776996,0.164443412366543,"ABCA5","ATP binding cassette subfamily A member 5",TRUE
+"217504_at",0.801285128907773,0.337971562689322,0.979367886975517,-5.48300698430663,0.641722219014825,"ABCA6","ATP binding cassette subfamily A member 6",TRUE
+"219577_s_at",0.943824539742785,0.748607664894265,0.32449410073861,-5.88852720672844,0.121721580849258,"ABCA7","ATP binding cassette subfamily A member 7",TRUE
+"1565778_at",0.891524108439685,0.561248464791842,-0.589865859424224,-5.77162016798628,-0.488723015253036,"ABCA8","ATP binding cassette subfamily A member 8",TRUE
+"1565780_at",0.939976205834042,0.730425261356242,-0.348944463168404,-5.88055097427195,-0.193766079718061,"ABCA8","ATP binding cassette subfamily A member 8",TRUE
+"204719_at",0.951934441578502,0.779941095191507,0.282818818139811,-5.900799930354,0.225755923291366,"ABCA8","ATP binding cassette subfamily A member 8",TRUE
+"235335_at",0.841247691968787,0.431318842907764,-0.801562776236991,-5.63149750306593,-0.659952673244718,"ABCA9","ATP binding cassette subfamily A member 9",TRUE
+"239185_at",0.929234395612144,0.689023268089097,-0.405466517714745,-5.85992448559839,-0.341202324426044,"ABCA9","ATP binding cassette subfamily A member 9",TRUE
+"242541_at",0.998940972058269,0.996565803766224,0.00435296376024575,-5.93967425173817,0.00319613915425876,"ABCA9","ATP binding cassette subfamily A member 9",TRUE
+"243951_at",0.843475287501313,0.438755746849296,0.788507295579184,-5.64130903198652,0.367068729388076,"ABCB1","ATP binding cassette subfamily B member 1",TRUE
+"209993_at",0.873688059772933,0.519331725769781,0.654808321430245,-5.73297394197852,0.621099337161433,"ABCB1","ATP binding cassette subfamily B member 1",TRUE
+"223320_s_at",0.841550580403629,0.432710453021061,0.799109293058649,-5.63335291967044,0.3639431747707,"ABCB10","ATP binding cassette subfamily B member 10",TRUE
+"211224_s_at",0.914488991533795,0.639832864785254,-0.474434105096952,-5.83064223687998,-0.339007859307584,"ABCB11","ATP binding cassette subfamily B member 11",TRUE
+"208288_at",0.971943273048675,0.865605075804926,-0.17121969688821,-5.92541472727135,-0.133000726357575,"ABCB11","ATP binding cassette subfamily B member 11",TRUE
+"207819_s_at",0.683017520100356,0.151268739228734,-1.48638736041895,-4.91732740903677,-1.4318524802621,"ABCB4","ATP binding cassette subfamily B member 4",TRUE
+"1570505_at",0.873099882222,0.517522301765666,0.657674458135119,-5.7311790331047,0.522191861392958,"ABCB4","ATP binding cassette subfamily B member 4",TRUE
+"209994_s_at",0.88698237223329,0.550989928330042,0.605514382125048,-5.76266359819944,0.504758930003886,"ABCB4///ABCB1","ATP binding cassette subfamily B member 4///ATP binding cassette subfamily B member 1",TRUE
+"1569072_s_at",0.656641058207682,0.124667612359361,1.59594110861951,-4.7698706924297,1.38320810711966,"ABCB5","ATP binding cassette subfamily B member 5",TRUE
+"243167_at",0.729041056651108,0.210526905231733,1.28948933012088,-5.16071303109421,0.485867167322614,"ABCB5","ATP binding cassette subfamily B member 5",TRUE
+"1555371_at",0.936318756756998,0.715986299062704,-0.368515843459661,-5.87375399132375,-0.173490526791399,"ABCB5","ATP binding cassette subfamily B member 5",TRUE
+"240717_at",0.998038817582822,0.991094713860047,0.0112879747183624,-5.93962142014791,0.0110612101580783,"ABCB5","ATP binding cassette subfamily B member 5",TRUE
+"203192_at",0.755639383619058,0.249752240494787,-1.18195915201934,-5.28122825820195,-0.540029495268056,"ABCB6","ATP binding cassette subfamily B member 6 (Langereis blood group)",TRUE
+"203191_at",0.797963285726587,0.332149253584772,-0.991494625933548,-5.47188800286591,-0.433214137738809,"ABCB6","ATP binding cassette subfamily B member 6 (Langereis blood group)",TRUE
+"209620_s_at",0.973071267819624,0.870501323216648,0.164921311120144,-5.92644450823707,0.0516740596080005,"ABCB7","ATP binding cassette subfamily B member 7",TRUE
+"229539_at",0.713633547141264,0.188763189336175,-1.35598660063678,-5.08172851413925,-0.440133516337006,"ABCB8","ATP binding cassette subfamily B member 8",TRUE
+"206317_s_at",0.832792886465252,0.409882613210792,0.839997681731725,-5.60173588494251,0.487860310034835,"ABCB8","ATP binding cassette subfamily B member 8",TRUE
+"207561_s_at",0.933859583363678,0.706935515858971,-0.380858477747735,-5.86927932021672,-0.182081464590243,"ABCB8///ASIC3","ATP binding cassette subfamily B member 8///acid sensing ion channel subunit 3",TRUE
+"207321_s_at",0.873301865850313,0.518238414044226,-0.656539471686876,-5.73189071398405,-0.306264005027431,"ABCB9","ATP binding cassette subfamily B member 9",TRUE
+"214209_s_at",0.925504446660705,0.67716585513811,-0.421896664548731,-5.85335770962564,-0.190581952602438,"ABCB9","ATP binding cassette subfamily B member 9",TRUE
+"1555323_at",0.96053687867756,0.820677087344189,-0.229380901488742,-5.91408880683063,-0.130064406629101,"ABCB9","ATP binding cassette subfamily B member 9",TRUE
+"202805_s_at",0.871619256677111,0.513068993777392,0.664752248774486,-5.72671439392828,0.286526940373186,"ABCC1","ATP binding cassette subfamily C member 1",TRUE
+"202804_at",0.968451827985008,0.852034705520369,0.188714167827809,-5.92235255457059,0.0566060679659461,"ABCC1","ATP binding cassette subfamily C member 1",TRUE
+"213485_s_at",0.520046545647116,0.037663352415539,2.21090156368696,-3.80374435304826,0.562805945525398,"ABCC10","ATP binding cassette subfamily C member 10",TRUE
+"215873_x_at",0.62986301194198,0.101051680424367,1.71097718707215,-4.60632700057411,0.403760504002713,"ABCC10","ATP binding cassette subfamily C member 10",TRUE
+"224146_s_at",0.637485146909712,0.108740860127937,-1.67123740981869,-4.663803702601,-3.21725830490968,"ABCC11","ATP binding cassette subfamily C member 11",TRUE
+"1554911_at",0.691295036264984,0.161012693311224,-1.45019849091207,-4.96418825299655,-0.876146876806478,"ABCC11","ATP binding cassette subfamily C member 11",TRUE
+"1552590_a_at",0.917102138198416,0.649042809812695,0.461352577790262,-5.83654232088948,0.335448199108849,"ABCC12","ATP binding cassette subfamily C member 12",TRUE
+"1553410_a_at",0.975550833930114,0.883455630223159,-0.148289457796468,-5.92897874994064,-0.128099482960328,"ABCC12","ATP binding cassette subfamily C member 12",TRUE
+"1552582_at",0.797127506889432,0.330310442053868,0.995354952858051,-5.4683223716905,0.67067398309336,"ABCC13","ATP binding cassette subfamily C member 13 (pseudogene)",TRUE
+"1552583_s_at",0.877857073443889,0.528903202759783,0.639737585389894,-5.74228808908609,0.652045669750584,"ABCC13","ATP binding cassette subfamily C member 13 (pseudogene)",TRUE
+"1555265_at",0.924812035112346,0.674581973720489,-0.425492568846765,-5.85188630290162,-0.343955764570992,"ABCC13","ATP binding cassette subfamily C member 13 (pseudogene)",TRUE
+"233371_at",0.928246500493356,0.68485661789486,0.411226845824501,-5.85765141368417,0.35600334967716,"ABCC13","ATP binding cassette subfamily C member 13 (pseudogene)",TRUE
+"206155_at",0.990623482682449,0.952575462032969,-0.0601499453009209,-5.93792143222293,-0.0862276012706431,"ABCC2","ATP binding cassette subfamily C member 2",TRUE
+"242553_at",0.624965128767163,0.0962455439986238,1.73714327202276,-4.56793045769779,1.47062799051184,"ABCC3","ATP binding cassette subfamily C member 3",TRUE
+"230682_x_at",0.65284137151906,0.121700701365609,1.60933103172171,-4.75128464263332,1.37627127624308,"ABCC3","ATP binding cassette subfamily C member 3",TRUE
+"239217_x_at",0.67818193964437,0.145516860641668,1.50864919997426,-4.88803879471638,1.01225541055033,"ABCC3","ATP binding cassette subfamily C member 3",TRUE
+"209641_s_at",0.726696341943087,0.206645022230113,1.3009444352388,-5.14734612034882,1.70441309819723,"ABCC3","ATP binding cassette subfamily C member 3",TRUE
+"208161_s_at",0.75959865506602,0.257461403161567,1.16234857918263,-5.30222413334609,1.92406624469462,"ABCC3","ATP binding cassette subfamily C member 3",TRUE
+"203196_at",0.863918945062466,0.490257221215932,-0.701560624066404,-5.70275910299095,-1.18285140750102,"ABCC4","ATP binding cassette subfamily C member 4",TRUE
+"243928_s_at",0.867216713941453,0.49932966386083,0.686807754415576,-5.71250854724069,0.539033890374308,"ABCC4","ATP binding cassette subfamily C member 4",TRUE
+"1555039_a_at",0.96820875250691,0.850460670013717,0.1907471617579,-5.92197746422246,0.1567076630307,"ABCC4","ATP binding cassette subfamily C member 4",TRUE
+"1554918_a_at",0.997352239065314,0.986602305276863,-0.0169828434540853,-5.93954300445232,-0.0263735717381151,"ABCC4","ATP binding cassette subfamily C member 4",TRUE
+"1558460_at",0.843095426822889,0.43735340012879,-0.7909586199965,-5.63947835912574,-0.41029973859524,"ABCC5","ATP binding cassette subfamily C member 5",TRUE
+"209380_s_at",0.870517518639056,0.509570965008395,-0.67033579284559,-5.72316001157798,-0.283748893010685,"ABCC5","ATP binding cassette subfamily C member 5",TRUE
+"226363_at",0.93560203991001,0.713128109944394,-0.372407193896804,-5.87235892734231,-0.189281930960274,"ABCC5","ATP binding cassette subfamily C member 5",TRUE
+"236205_at",0.871451481476429,0.51218853615187,-0.666155627510962,-5.72582370805541,-0.648290454669469,"ABCC6P1","ATP binding cassette subfamily C member 6 pseudogene 1",TRUE
+"210245_at",0.709914655587487,0.18286857301525,1.37502853916725,-5.05849839109319,0.410146661672089,"ABCC8","ATP binding cassette subfamily C member 8",TRUE
+"210246_s_at",0.734861913384601,0.219880142197832,-1.26254391512901,-5.19175819336967,-0.76318418364713,"ABCC8","ATP binding cassette subfamily C member 8",TRUE
+"208561_at",0.597879550155311,0.0753276160532043,1.86605272682741,-4.37257602936544,1.74025902946007,"ABCC9","ATP binding cassette subfamily C member 9",TRUE
+"208562_s_at",0.820288124919738,0.37875274928355,0.898168365348417,-5.55422406375669,0.689079500044543,"ABCC9","ATP binding cassette subfamily C member 9",TRUE
+"208462_s_at",0.895690630367785,0.57618788280797,0.567338644291979,-5.78411532700047,0.238214186825243,"ABCC9","ATP binding cassette subfamily C member 9",TRUE
+"1557374_at",0.904381089098038,0.607133301355162,-0.521586531643362,-5.80803841686031,-0.214539718989273,"ABCC9","ATP binding cassette subfamily C member 9",TRUE
+"235578_at",0.91543081876046,0.64359335083271,-0.469082802696103,-5.83307532295889,-0.399483334933888,"ABCC9","ATP binding cassette subfamily C member 9",TRUE
+"205142_x_at",0.725583196024696,0.204678548714607,-1.30681112231003,-5.14046150137766,-0.593371160052937,"ABCD1","ATP binding cassette subfamily D member 1",TRUE
+"207583_at",0.732582817014232,0.216914187922147,-1.27099127983945,-5.18208578491829,-1.19325698627995,"ABCD2","ATP binding cassette subfamily D member 2",TRUE
+"202850_at",0.961212424803935,0.824291434074898,-0.224674679760817,-5.91512702546912,-0.0972844328065161,"ABCD3","ATP binding cassette subfamily D member 3",TRUE
+"1554878_a_at",0.973071267819624,0.870324789577638,0.16514827850124,-5.92640806772981,0.0864360810576841,"ABCD3","ATP binding cassette subfamily D member 3",TRUE
+"203982_s_at",0.694505490882266,0.163754092602611,1.44033696996834,-4.97679515747585,0.848335245596304,"ABCD4","ATP binding cassette subfamily D member 4",TRUE
+"203981_s_at",0.700061364939874,0.171730617384976,-1.4123795072576,-5.01215296266714,-0.561148790464967,"ABCD4","ATP binding cassette subfamily D member 4",TRUE
+"201872_s_at",0.878647293269438,0.531636536965646,0.635461198740326,-5.74489305939116,0.215714325334485,"ABCE1","ATP binding cassette subfamily E member 1",TRUE
+"201873_s_at",0.939976205834042,0.730090088830575,0.349397173702235,-5.88039789081451,0.123400999475225,"ABCE1","ATP binding cassette subfamily E member 1",TRUE
+"200045_at",0.823074246722209,0.389498281429638,0.877750094651075,-5.57123743370351,0.23105926773443,"ABCF1","ATP binding cassette subfamily F member 1",TRUE
+"207622_s_at",0.527826453640453,0.04039422820701,-2.17718759097774,-3.86207801267342,-0.7737910741172,"ABCF2","ATP binding cassette subfamily F member 2",TRUE
+"209246_at",0.610660880283135,0.0832940743839323,-1.81368727327391,-4.45315204533864,-0.703020223000499,"ABCF2","ATP binding cassette subfamily F member 2",TRUE
+"209247_s_at",0.630603891142543,0.101625361418061,-1.70792516213188,-4.6107772292153,-0.601699982445314,"ABCF2","ATP binding cassette subfamily F member 2",TRUE
+"207623_at",0.838610044014507,0.423724534987072,-0.81503936456799,-5.62121077660485,-0.72727769391368,"ABCF2","ATP binding cassette subfamily F member 2",TRUE
+"214232_at",0.99783553534859,0.989869770894309,-0.0128407458778599,-5.93960317178341,-0.00532350516356139,"ABCF2","ATP binding cassette subfamily F member 2",TRUE
+"202394_s_at",0.98693003519805,0.939835376545435,-0.0763379238058765,-5.93684552932022,-0.0223522722969705,"ABCF3","ATP binding cassette subfamily F member 3",TRUE
+"232081_at",0.704427751516111,0.176312419629416,-1.39678751989175,-5.03162448520106,-1.26871275465314,"ABCG1","ATP binding cassette subfamily G member 1",TRUE
+"211113_s_at",0.70916118893503,0.181959383612039,-1.37800864802859,-5.0548384298228,-0.914016837894176,"ABCG1","ATP binding cassette subfamily G member 1",TRUE
+"204567_s_at",0.729210170056086,0.211292731777987,-1.28724877910331,-5.16331577287661,-1.77969441607734,"ABCG1","ATP binding cassette subfamily G member 1",TRUE
+"230913_at",0.849619613504567,0.450812596992386,-0.767626692317006,-5.65668564706244,-0.436020294023393,"ABCG1","ATP binding cassette subfamily G member 1",TRUE
+"209735_at",0.527546822913581,0.0399846067021813,2.18211023678542,-3.85359499582466,1.84097821117792,"ABCG2","ATP binding cassette subfamily G member 2 (Junior blood group)",TRUE
+"207593_at",0.737897493665289,0.224607112001633,1.24925974684746,-5.20685703516393,0.381342753960824,"ABCG4","ATP binding cassette subfamily G member 4",TRUE
+"220383_at",0.896159990898752,0.579344692058661,-0.562616579898662,-5.78667474632355,-0.251208130756071,"ABCG5","ATP binding cassette subfamily G member 5",TRUE
+"231751_at",0.616413638398853,0.0872232015771738,1.78944221066378,-4.48989864362268,0.821912221227206,"ABCG8","ATP binding cassette subfamily G member 8",TRUE
+"236461_at",0.877861946695164,0.529279006748651,-0.63914891774366,-5.74264767422221,-0.314169167118243,"ABHD1","abhydrolase domain containing 1",TRUE
+"232550_at",0.930527241884777,0.692684915168797,-0.400415851982146,-5.86189154923548,-0.269489058302792,"ABHD1","abhydrolase domain containing 1",TRUE
+"1560117_at",0.976371465776674,0.887034527687028,0.143702305349372,-5.92963045778319,0.04940104419794,"ABHD1","abhydrolase domain containing 1",TRUE
+"222697_s_at",0.925511384407886,0.677969635504528,0.42077922401943,-5.85381245479008,0.444857093219859,"ABHD10","abhydrolase domain containing 10",TRUE
+"218633_x_at",0.975398143273847,0.881119753478898,0.151285154729987,-5.92854211482064,0.0735311581896241,"ABHD10","abhydrolase domain containing 10",TRUE
+"221927_s_at",0.58087491336149,0.0635111153557382,-1.95342426321381,-4.2345620854452,-1.02182451079284,"ABHD11","abhydrolase domain containing 11",TRUE
+"1552800_at",0.642592458809121,0.112615486761642,-1.65210641549365,-4.69110792601773,-1.32734270327864,"ABHD11","abhydrolase domain containing 11",TRUE
+"1552470_a_at",0.651890684512311,0.121149725566156,-1.61184758092852,-4.74777807168475,-1.06088128459414,"ABHD11","abhydrolase domain containing 11",TRUE
+"228124_at",0.641880516735663,0.112182882078076,-1.654214621271,-4.68811079486045,-1.04557979530814,"ABHD12","abhydrolase domain containing 12",TRUE
+"224742_at",0.706880829211624,0.178623969572708,-1.38904352554834,-5.04122893646146,-0.632606119532815,"ABHD12","abhydrolase domain containing 12",TRUE
+"228123_s_at",0.708894565317004,0.181176636729892,-1.38058377845798,-5.0516705351518,-0.690974739775545,"ABHD12","abhydrolase domain containing 12",TRUE
+"234993_at",0.82455893188708,0.391987851076525,0.873072065943597,-5.57508426904682,0.543157399588304,"ABHD13","abhydrolase domain containing 13",TRUE
+"235348_at",0.930065981387326,0.691325268866677,0.402290026141616,-5.86116445418506,0.189123589450752,"ABHD13","abhydrolase domain containing 13",TRUE
+"202740_at",0.909207738322331,0.623133651036386,-0.498371162579862,-5.81942847558231,-0.153282270192431,"ABHD14A-ACY1///ACY1","ABHD14A-ACY1 readthrough///aminoacylase 1",TRUE
+"210006_at",0.942303845415102,0.740238498277119,0.33572237490569,-5.88493543959768,0.175979918299568,"ABHD14A///ACY1","abhydrolase domain containing 14A///aminoacylase 1",TRUE
+"224821_at",0.965380895563592,0.838531819962334,0.206181659244722,-5.91899918552684,0.0882658010789132,"ABHD14B","abhydrolase domain containing 14B",TRUE
+"226796_at",0.954723352940649,0.793807814383661,0.264541691952213,-5.90565504521537,0.109582189745812,"ABHD15","abhydrolase domain containing 15",TRUE
+"230221_at",0.668620158511127,0.134946986880008,1.5515103822498,-4.83067250431298,0.899805757130219,"ABHD16A","abhydrolase domain containing 16A",TRUE
+"224756_s_at",0.812302873476553,0.357251169658067,-0.940203700077827,-5.51806242801977,-0.337769427904771,"ABHD16A","abhydrolase domain containing 16A",TRUE
+"234002_at",0.861659105448003,0.483269812484205,0.713030201006232,-5.69504295560047,0.215989246437606,"ABHD16B","abhydrolase domain containing 16B",TRUE
+"221267_s_at",0.737037362362438,0.222425541453685,-1.25536374384626,-5.1999362129057,-0.37937523458702,"ABHD17A","abhydrolase domain containing 17A",TRUE
+"220285_at",0.580137756009815,0.0626719101447607,-1.96016012751556,-4.22374141466786,-0.72139759261676,"ABHD17B","abhydrolase domain containing 17B",TRUE
+"227551_at",0.645072069975909,0.115477233933056,-1.63832949441637,-4.71062184714627,-0.480763283452847,"ABHD17B","abhydrolase domain containing 17B",TRUE
+"228872_at",0.65284137151906,0.122113983974849,1.60744962874071,-4.75390342409669,0.874370398712506,"ABHD17B","abhydrolase domain containing 17B",TRUE
+"225436_at",0.909420782434696,0.623595693722162,0.497704938393232,-5.81974787427982,0.273303299650346,"ABHD17C","abhydrolase domain containing 17C",TRUE
+"241968_at",0.605509180163047,0.079095501869675,-1.84071466406744,-4.4117688825541,-0.529395116772531,"ABHD18","abhydrolase domain containing 18",TRUE
+"236240_at",0.744706562599365,0.236227217805706,-1.21748681570912,-5.24241225346624,-0.484723844867855,"ABHD18","abhydrolase domain containing 18",TRUE
+"219980_at",0.83872852514497,0.424008348879034,-0.814533022100977,-5.62160017900754,-0.269265719462152,"ABHD18","abhydrolase domain containing 18",TRUE
+"228490_at",0.67368843181164,0.140184269512275,-1.52994094468368,-4.8597010982151,-0.652083854045191,"ABHD2","abhydrolase domain containing 2",TRUE
+"221815_at",0.755049574909504,0.248738865820821,-1.18457038589748,-5.27840941415383,-0.488572350510917,"ABHD2","abhydrolase domain containing 2",TRUE
+"87100_at",0.8920930097751,0.56370218028665,-0.58614499199935,-5.77371647953958,-0.186280051194057,"ABHD2","abhydrolase domain containing 2",TRUE
+"63825_at",0.894729774938685,0.571914548829607,-0.573751697291827,-5.78060617228968,-0.235637523904455,"ABHD2","abhydrolase domain containing 2",TRUE
+"225337_at",0.934081042629428,0.708326114999965,-0.378958232113057,-5.86997770026832,-0.186416341821834,"ABHD2","abhydrolase domain containing 2",TRUE
+"205566_at",0.952239474918707,0.781338834434283,-0.280972158408469,-5.90130509113429,-0.11796238032478,"ABHD2","abhydrolase domain containing 2",TRUE
+"213017_at",0.578003664774837,0.0616385201392123,1.96856496196885,-4.21020411730985,0.880766172225519,"ABHD3","abhydrolase domain containing 3",TRUE
+"218581_at",0.877339406737153,0.527238059207364,-0.642348646328956,-5.74068929835418,-0.23797772369752,"ABHD4","abhydrolase domain containing 4",TRUE
+"242023_at",0.916926467520432,0.648671046661852,-0.461879023851684,-5.83630800090344,-0.206408654836831,"ABHD4","abhydrolase domain containing 4",TRUE
+"213935_at",0.636880286417585,0.108004645919778,-1.67493738396091,-4.65849543893424,-0.597831895020963,"ABHD5","abhydrolase domain containing 5",TRUE
+"213805_at",0.874573785074124,0.520985892928213,-0.652192929790856,-5.73460525923581,-0.233592503385246,"ABHD5","abhydrolase domain containing 5",TRUE
+"232862_at",0.955515814503015,0.796145967326704,0.261469095489001,-5.90643962941543,0.190818163841441,"ABHD5","abhydrolase domain containing 5",TRUE
+"218739_at",0.99872918752906,0.994603800124592,0.00683990511758518,-5.9396606938662,0.00215922207108932,"ABHD5","abhydrolase domain containing 5",TRUE
+"221552_at",0.856852764868387,0.471030284576535,0.733355766503384,-5.68107664186372,0.472912431627026,"ABHD6","abhydrolase domain containing 6",TRUE
+"221678_at",0.967098323798013,0.84642730529599,-0.195960356398686,-5.92099732061873,-0.153968941973786,"ABHD6","abhydrolase domain containing 6",TRUE
+"45288_at",0.973493137611142,0.87213023391941,0.16282745509776,-5.92677832742214,0.0715865906904192,"ABHD6","abhydrolase domain containing 6",TRUE
+"221679_s_at",0.989475734766121,0.94807712507627,0.0658635735102276,-5.93757081672511,0.0283492142872008,"ABHD6","abhydrolase domain containing 6",TRUE
+"219101_x_at",0.945664467195782,0.754803341440431,0.31620924082848,-5.89109987334188,0.231301950256859,"ABHD8","abhydrolase domain containing 8",TRUE
+"1559890_a_at",0.702888118552354,0.174802910237874,-1.40188832731792,-5.02527413596182,-0.792506352872934,"ABI1","abl interactor 1",TRUE
+"209027_s_at",0.965992617204023,0.840999899448104,0.202984181101721,-5.91963512651321,0.0541453645136993,"ABI1","abl interactor 1",TRUE
+"209028_s_at",0.998347572104896,0.992244835431151,-0.00983007516583522,-5.9396364157644,-0.00340893423227762,"ABI1","abl interactor 1",TRUE
+"225112_at",0.604522328036066,0.078679120005572,-1.84346245688099,-4.40753704552766,-0.887235232923228,"ABI2","abl-interactor 2",TRUE
+"231075_x_at",0.643688366500038,0.114589958986179,-1.64256997124255,-4.70462888304088,-0.730548963190269,"ABI2","abl-interactor 2",TRUE
+"227631_at",0.737488397392592,0.223794823312378,1.25152719937965,-5.20428953648301,0.410890832997457,"ABI2","abl-interactor 2",TRUE
+"209856_x_at",0.755868740464627,0.250319526642928,-1.18050083869188,-5.28280015404172,-0.551111362119526,"ABI2","abl-interactor 2",TRUE
+"225098_at",0.76912869907427,0.275113854006319,-1.11902722580486,-5.34751001714652,-0.508457394306019,"ABI2","abl-interactor 2",TRUE
+"216113_at",0.793059236709526,0.324925833772841,-1.00674548760083,-5.45772809567521,-0.774596700369504,"ABI2","abl-interactor 2",TRUE
+"207268_x_at",0.793672728437026,0.325496544851275,-1.00553203257513,-5.45886192692967,-0.44391158031249,"ABI2","abl-interactor 2",TRUE
+"211793_s_at",0.841420204214686,0.432380725796994,-0.799690177701435,-5.63291411581819,-0.351701382673953,"ABI2","abl-interactor 2",TRUE
+"223615_at",0.948419621702021,0.764806970660121,-0.302879619406992,-5.8951007346017,-0.105001466663294,"ABI3","ABI family member 3",TRUE
+"220518_at",0.953622331321215,0.786496420416416,-0.274166649779858,-5.90313840606718,-0.198652720648147,"ABI3BP","ABI family member 3 binding protein",TRUE
+"223395_at",0.996771621728225,0.983683760248399,-0.0206828769857055,-5.93947512634901,-0.0277575210459426,"ABI3BP","ABI family member 3 binding protein",TRUE
+"1559077_at",0.998940972058269,0.996552963876656,0.0043692388770982,-5.93967418259725,0.00482570674169835,"ABI3BP","ABI family member 3 binding protein",TRUE
+"202123_s_at",0.784132959865516,0.307271123276062,-1.0450428772009,-5.42130921512054,-0.420796116349242,"ABL1","ABL proto-oncogene 1, non-receptor tyrosine kinase",TRUE
+"231907_at",0.643688366500038,0.114437300793644,1.64330233853895,-4.70359264315056,0.781523302089099,"ABL2","ABL proto-oncogene 2, non-receptor tyrosine kinase",TRUE
+"206411_s_at",0.792610942614642,0.324140776493348,1.00841711366651,-5.45616412796094,0.35268360075522,"ABL2","ABL proto-oncogene 2, non-receptor tyrosine kinase",TRUE
+"226893_at",0.923376218980614,0.671046389292178,0.43042219685193,-5.84984920986173,0.268257329277262,"ABL2","ABL proto-oncogene 2, non-receptor tyrosine kinase",TRUE
+"210461_s_at",0.671298718565642,0.137425313663544,1.54121915015623,-4.8445628023052,0.94071552859985,"ABLIM1","actin binding LIM protein 1",TRUE
+"200965_s_at",0.792611633508961,0.324221969518553,1.00824409845023,-5.45632610949124,0.904042451459365,"ABLIM1","actin binding LIM protein 1",TRUE
+"1567622_at",0.501591596209182,0.0322163609593472,2.28537752005697,-3.67297033758535,0.833137413386374,"ABLIM2","actin binding LIM protein family member 2",TRUE
+"1567623_at",0.639656559005154,0.110077681817451,1.664572762157,-4.67334281237527,0.52258537470301,"ABLIM2","actin binding LIM protein family member 2",TRUE
+"236087_at",0.670152406964446,0.135774857222034,-1.54805543970751,-4.83534386227284,-1.16718408108815,"ABLIM2","actin binding LIM protein family member 2",TRUE
+"228132_at",0.886023097762234,0.548645109192226,0.609112571298755,-5.76057212975373,0.24558463447366,"ABLIM2","actin binding LIM protein family member 2",TRUE
+"242624_at",0.913782990161554,0.638525541566843,-0.476297761227495,-5.82978854449404,-0.408267578993815,"ABLIM2","actin binding LIM protein family member 2",TRUE
+"205730_s_at",0.732443812350949,0.216799708329858,1.27131910454115,-5.18170930763766,1.35653808763986,"ABLIM3","actin binding LIM protein family member 3",TRUE
+"216716_at",0.55937703282623,0.0536782106220559,-2.03785683986914,-4.09711909936847,-0.770711485373155,"ABO","ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)",TRUE
+"216929_x_at",0.808233282592165,0.350311695055836,0.954131162838365,-5.50574607300828,0.549315970819316,"ABO","ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)",TRUE
+"214504_at",0.952644489493803,0.783191878608287,0.278525496920679,-5.90196932638932,0.133583023961061,"ABO","ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)",TRUE
+"1564121_at",0.690330257199992,0.159899196830419,1.4542427458427,-4.95899785864723,0.960622513332227,"ABR","active BCR-related",TRUE
+"212895_s_at",0.798535466562538,0.333084282835579,-0.98953732287395,-5.47369107423839,-0.415017706148998,"ABR","active BCR-related",TRUE
+"214671_s_at",0.986342822130003,0.935190274864369,0.0822451151878872,-5.93638939656316,0.0387381245739409,"ABR","active BCR-related",TRUE
+"1552731_at",0.936992192746977,0.719135993849775,-0.364234316155887,-5.8752722227455,-0.287414423517117,"ABRA","actin binding Rho activating protein",TRUE
+"1552732_at",0.963105278285472,0.832225127985316,0.2143622688115,-5.91732710462538,0.0940899831280335,"ABRA","actin binding Rho activating protein",TRUE
+"223361_at",0.315346485364445,0.00679429647479317,2.98495429541719,-2.33834445302782,1.11939308337314,"ABRACL","ABRA C-terminal like",TRUE
+"218405_at",0.891729096865953,0.561736324723496,0.589125390080093,-5.77203836587513,0.196128015097683,"ABT1","activator of basal transcription 1",TRUE
+"229164_s_at",0.509163975230892,0.0337874898083058,2.26278382306952,-3.7129159888229,1.94504686249923,"ABTB1","ankyrin repeat and BTB domain containing 1",TRUE
+"242567_at",0.692289844352812,0.161711677692496,1.44767127923111,-4.96742570259993,0.800886105970308,"ABTB1","ankyrin repeat and BTB domain containing 1",TRUE
+"226442_at",0.734730148360473,0.219645870966552,1.26320795305963,-5.19099985445782,1.16048102445623,"ABTB1","ankyrin repeat and BTB domain containing 1",TRUE
+"229162_s_at",0.796087253224861,0.328277699336218,0.999639753560875,-5.46434993656825,0.626068408717122,"ABTB1","ankyrin repeat and BTB domain containing 1",TRUE
+"228848_at",0.887059215762685,0.551282763464111,0.605065585158888,-5.76292362519814,0.389395122081537,"ABTB1","ankyrin repeat and BTB domain containing 1",TRUE
+"213497_at",0.844608293507187,0.441474441108374,-0.783768639542658,-5.64483273350223,-0.357801640307814,"ABTB2","ankyrin repeat and BTB domain containing 2",TRUE
+"232624_at",0.875279162021058,0.522427346717813,-0.649917582489891,-5.7360193811051,-0.380408863874451,"ABTB2","ankyrin repeat and BTB domain containing 2",TRUE
+"202025_x_at",0.961475152596758,0.825339156920215,0.223311419717449,-5.91542376770024,0.0793008877998336,"ACAA1","acetyl-CoA acyltransferase 1",TRUE
+"214274_s_at",0.995025131654789,0.976558095551208,-0.0297179061542454,-5.93925333817822,-0.0119268892408098,"ACAA1","acetyl-CoA acyltransferase 1",TRUE
+"202002_at",0.729083413548563,0.211094910362764,-1.28782693600998,-5.16264452397343,-0.719102440413641,"ACAA2","acetyl-CoA acyltransferase 2",TRUE
+"202003_s_at",0.887624041154914,0.552137057881639,0.603757015032753,-5.76368073091035,0.591501337976364,"ACAA2","acetyl-CoA acyltransferase 2",TRUE
+"241114_s_at",0.977369242833284,0.891638020312514,0.13780653119009,-5.93043807097985,0.107872615774891,"ACAA2","acetyl-CoA acyltransferase 2",TRUE
+"214358_at",0.597654932724127,0.0743653796784415,-1.8727003343498,-4.36223068616194,-0.965929020802513,"ACACA","acetyl-CoA carboxylase alpha",TRUE
+"212186_at",0.863498371484347,0.488267519151379,-0.704816985620609,-5.70058050957833,-0.310503596709353,"ACACA","acetyl-CoA carboxylase alpha",TRUE
+"49452_at",0.724970327905974,0.203010018440228,-1.31182338917912,-5.13455878785383,-0.802741159513295,"ACACB","acetyl-CoA carboxylase beta",TRUE
+"43427_at",0.739189560382301,0.226259631980863,-1.24466609758249,-5.21204628846207,-1.08148865211644,"ACACB","acetyl-CoA carboxylase beta",TRUE
+"1552615_at",0.774230543658252,0.287328734012834,-1.09022617222633,-5.37677388451155,-0.25982585839545,"ACACB","acetyl-CoA carboxylase beta",TRUE
+"214584_x_at",0.796838451167002,0.329654061246464,-0.996736531288763,-5.46704320403418,-0.867120182511479,"ACACB","acetyl-CoA carboxylase beta",TRUE
+"1552616_a_at",0.861357981297227,0.48179848488681,-0.715457544858119,-5.69339468580973,-0.542454596951899,"ACACB","acetyl-CoA carboxylase beta",TRUE
+"221928_at",0.930457281281851,0.692377936313527,-0.400838872372648,-5.86172772851953,-0.33736047204833,"ACACB","acetyl-CoA carboxylase beta",TRUE
+"1565740_at",0.951934441578502,0.780092403820497,0.28261886442207,-5.90085478699057,0.204150983260262,"ACACB","acetyl-CoA carboxylase beta",TRUE
+"237482_s_at",0.726636642789909,0.206286958502901,-1.30200942892117,-5.14609828890672,-0.460093413158833,"ACAD10","acyl-CoA dehydrogenase family member 10",TRUE
+"237481_at",0.888232641270866,0.554038802345612,0.60084781580849,-5.765358249879,0.388842842002235,"ACAD10","acyl-CoA dehydrogenase family member 10",TRUE
+"219986_s_at",0.918409982899324,0.65366345517769,0.454820353455866,-5.83942801612328,0.243391800372323,"ACAD10","acyl-CoA dehydrogenase family member 10",TRUE
+"238655_at",0.980663666733946,0.909469939634818,-0.1150140576798,-5.93324254911454,-0.0324748135447956,"ACAD10","acyl-CoA dehydrogenase family member 10",TRUE
+"221669_s_at",0.464325074629755,0.0238638035612183,-2.42577907774585,-3.41966936094874,-0.98790794416189,"ACAD8","acyl-CoA dehydrogenase family member 8",TRUE
+"239976_at",0.566644160327613,0.0570841524478188,-2.00716159836916,-4.14753665844191,-0.731142992571066,"ACAD9","acyl-CoA dehydrogenase family member 9",TRUE
+"224160_s_at",0.983783029912313,0.920968460960802,0.100350633521228,-5.93477982341828,0.0291440948132848,"ACAD9","acyl-CoA dehydrogenase family member 9",TRUE
+"206068_s_at",0.672164152353115,0.138047211097817,1.53866076091488,-4.84800455946005,1.13753994802775,"ACADL","acyl-CoA dehydrogenase, long chain",TRUE
+"206069_s_at",0.887706911509597,0.552571804933818,0.603091496915958,-5.76406517587227,0.436845847078242,"ACADL","acyl-CoA dehydrogenase, long chain",TRUE
+"202502_at",0.819018525257656,0.374385980510733,0.906574605535966,-5.5471144695391,0.396552780771232,"ACADM","acyl-CoA dehydrogenase, C-4 to C-12 straight chain",TRUE
+"202366_at",0.699391325858549,0.17085814789279,1.41538612785206,-5.00837778188354,0.676020517316053,"ACADS","acyl-CoA dehydrogenase, C-2 to C-3 short chain",TRUE
+"205355_at",0.603702127972549,0.0776077906996067,-1.85059094645761,-4.39653758407286,-1.07043808141875,"ACADSB","acyl-CoA dehydrogenase, short/branched chain",TRUE
+"226030_at",0.702421895253027,0.173848616123712,-1.40513115037077,-5.02122699046442,-1.18889876879122,"ACADSB","acyl-CoA dehydrogenase, short/branched chain",TRUE
+"200710_at",0.238811487311851,0.0031645565445797,3.30995830388204,-1.67040377206089,1.20182182153563,"ACADVL","acyl-CoA dehydrogenase, very long chain",TRUE
+"1554950_at",0.67368843181164,0.140307090499116,1.52944313022719,-4.86036726086852,0.8089253404789,"ACAN","aggrecan",TRUE
+"205679_x_at",0.677509122383198,0.144951809471197,1.5108747260108,-4.88509162408088,0.770275375873365,"ACAN","aggrecan",TRUE
+"207692_s_at",0.859544466207891,0.477520859653714,0.722539227726653,-5.68855546943203,0.247885708106809,"ACAN","aggrecan",TRUE
+"217161_x_at",0.90998880119877,0.625336966488913,0.495196226146353,-5.82094684829007,0.403534513939353,"ACAN","aggrecan",TRUE
+"242081_at",0.774230543658252,0.288224454699209,1.08814932006231,-5.3788578695059,0.485179315723548,"ACAP1","ArfGAP with coiled-coil, ankyrin repeat and PH domains 1",TRUE
+"205213_at",0.893600768892136,0.568811987848442,0.578423013038634,-5.77802602723447,0.154148968521425,"ACAP1","ArfGAP with coiled-coil, ankyrin repeat and PH domains 1",TRUE
+"205212_s_at",0.959335452306759,0.81559743629767,-0.236004079683931,-5.912591427898,-0.171264594053739,"ACAP1","ArfGAP with coiled-coil, ankyrin repeat and PH domains 1",TRUE
+"212477_at",0.581336273502073,0.0637742106715214,1.9513287100321,-4.23792325064399,0.804723074232346,"ACAP2","ArfGAP with coiled-coil, ankyrin repeat and PH domains 2",TRUE
+"212476_at",0.662855903464759,0.130852536500543,1.56885985409116,-4.80709063773862,0.531780778922698,"ACAP2","ArfGAP with coiled-coil, ankyrin repeat and PH domains 2",TRUE
+"1552472_a_at",0.7974001826642,0.330716359123788,0.994501511546877,-5.46911174558779,0.306126034531154,"ACAP2","ArfGAP with coiled-coil, ankyrin repeat and PH domains 2",TRUE
+"225542_at",0.716472449896956,0.192500782606059,-1.34415431975707,-5.0960268727792,-0.580807963481528,"ACAP3","ArfGAP with coiled-coil, ankyrin repeat and PH domains 3",TRUE
+"225529_at",0.739189560382301,0.226062560622059,-1.24521256640746,-5.21142982659016,-0.531028296779164,"ACAP3","ArfGAP with coiled-coil, ankyrin repeat and PH domains 3",TRUE
+"1554947_at",0.767727587789514,0.269811071526207,1.13182083052041,-5.33429408781228,0.736266005838629,"ACAT1","acetyl-CoA acetyltransferase 1",TRUE
+"1559239_s_at",0.885029460971826,0.545425956978722,0.614065699183532,-5.75767354335743,0.503191810986975,"ACAT1","acetyl-CoA acetyltransferase 1",TRUE
+"205412_at",0.965584868976477,0.839064920968777,0.205490824316869,-5.91913742284239,0.0888919375604598,"ACAT1","acetyl-CoA acetyltransferase 1",TRUE
+"209608_s_at",0.6287528932499,0.0998445128968674,1.71744789074561,-4.59687225419743,0.561150800495383,"ACAT2","acetyl-CoA acetyltransferase 2",TRUE
+"202323_s_at",0.854090364629323,0.463403578723893,0.746178661508845,-5.672073977631,0.329417396017046,"ACBD3","acyl-CoA binding domain containing 3",TRUE
+"202324_s_at",0.974982245454858,0.877994724531512,0.155295140325078,-5.9279440054652,0.0560010283963823,"ACBD3","acyl-CoA binding domain containing 3",TRUE
+"219413_at",0.91671872326659,0.648024796532695,-0.462794480798707,-5.83589990963083,-0.192151463026384,"ACBD4","acyl-CoA binding domain containing 4",TRUE
+"225663_at",0.619611160248431,0.0896977107154336,-1.77465229956557,-4.51213787685231,-0.690345407532154,"ACBD5","acyl-CoA binding domain containing 5",TRUE
+"1568877_a_at",0.671655467883069,0.137789643907869,-1.53971919810212,-4.84658121144862,-0.503710788092169,"ACBD5","acyl-CoA binding domain containing 5",TRUE
+"225317_at",0.722132846415286,0.198300915520423,-1.32614476804908,-5.11758805601669,-0.42500191497078,"ACBD6","acyl-CoA binding domain containing 6",TRUE
+"228264_at",0.977650262809173,0.892250031347324,-0.137023099085391,-5.93054284535086,-0.0700418665937219,"ACCS","1-aminocyclopropane-1-carboxylate synthase homolog (inactive)",TRUE
+"204617_s_at",0.872668627020452,0.516785821777196,-0.658842632559041,-5.7304453109822,-0.233017429199156,"ACD","adrenocortical dysplasia homolog",TRUE
+"209749_s_at",0.774230543658252,0.287342531988742,1.09019414433438,-5.37680604928124,0.754939036004197,"ACE","angiotensin I converting enzyme",TRUE
+"227463_at",0.846560766727904,0.444919796809482,0.777789005834686,-5.64925066540342,0.698776426553386,"ACE","angiotensin I converting enzyme",TRUE
+"219962_at",0.774230543658252,0.287179909296554,1.09057169501796,-5.37642683152951,0.959242240681357,"ACE2","angiotensin I converting enzyme 2",TRUE
+"222257_s_at",0.913221029035633,0.63592185265773,0.480014565725749,-5.82807619727044,0.467813220311076,"ACE2","angiotensin I converting enzyme 2",TRUE
+"1553929_at",0.825648186672984,0.393142969497431,-0.870908084249739,-5.57685729500821,-0.486920648077608,"ACER1","alkaline ceramidase 1",TRUE
+"227306_at",0.952807406768689,0.784075765876348,0.277359071264734,-5.90228396534448,0.21719084822265,"ACER2","alkaline ceramidase 2",TRUE
+"222689_at",0.544906469224564,0.0468215929111477,-2.1053277938334,-3.98454139072649,-1.12751094459308,"ACER3","alkaline ceramidase 3",TRUE
+"227776_at",0.679041081350052,0.146498589473987,-1.50479929266805,-4.89312885744032,-0.76635000337277,"ACER3","alkaline ceramidase 3",TRUE
+"222688_at",0.741523961884758,0.23205258322539,-1.22876205797072,-5.22988524378142,-0.591486959451263,"ACER3","alkaline ceramidase 3",TRUE
+"222687_s_at",0.758189649141895,0.255089505472358,-1.16833514965843,-5.29584726849075,-0.469415261913037,"ACER3","alkaline ceramidase 3",TRUE
+"238945_at",0.790361168948463,0.32009085256563,-1.01708574817691,-5.44801610629755,-0.49176072419189,"ACER3","alkaline ceramidase 3",TRUE
+"231321_s_at",0.957571530817866,0.808937649194557,-0.244703972669117,-5.91056013583465,-0.127371115983086,"ACER3","alkaline ceramidase 3",TRUE
+"210332_at",0.667641453131852,0.134030889770953,1.55535398169222,-4.82546599471239,0.710205427293246,"ACHE","acetylcholinesterase (Cartwright blood group)",TRUE
+"205378_s_at",0.852510480879199,0.458523561247638,-0.754449493750972,-5.66618877712417,-0.765132316234143,"ACHE","acetylcholinesterase (Cartwright blood group)",TRUE
+"205377_s_at",0.878278790222455,0.531159880704082,-0.636206081999085,-5.74444052041012,-0.526940945215144,"ACHE","acetylcholinesterase (Cartwright blood group)",TRUE
+"201715_s_at",0.860994442844737,0.481049199133132,-0.71669534579444,-5.69255211387858,-0.240248424028687,"ACIN1","apoptotic chromatin condensation inducer 1",TRUE
+"208335_s_at",0.8920930097751,0.563502947268362,0.58644680123838,-5.77354692041366,0.225893181836947,"ACKR1","atypical chemokine receptor 1 (Duffy blood group)",TRUE
+"1568850_at",0.525243770035611,0.039214358834666,2.19149180780243,-3.83739536639544,1.31320582583016,"ACKR2","atypical chemokine receptor 2",TRUE
+"206887_at",0.8920930097751,0.563442926100734,0.586537735411625,-5.77349581623098,0.259027205350449,"ACKR2","atypical chemokine receptor 2",TRUE
+"1559432_at",0.90227173306771,0.601123814936119,0.530380708154993,-5.8035918503138,0.445689754260065,"ACKR2","atypical chemokine receptor 2",TRUE
+"1559114_a_at",0.859486825765374,0.477141254113242,-0.723169457241885,-5.68812261032312,-0.512315197603292,"ACKR3","atypical chemokine receptor 3",TRUE
+"212977_at",0.932091525948902,0.699842580124152,-0.390573363620027,-5.86565509199321,-0.832571587656865,"ACKR3","atypical chemokine receptor 3",TRUE
+"232746_at",0.954577684533304,0.792930089407352,0.265695791923644,-5.90535799492234,0.114838170824886,"ACKR3","atypical chemokine receptor 3",TRUE
+"220351_at",0.929234395612144,0.688882428067275,0.405660997973871,-5.85984825684117,0.272990567809462,"ACKR4","atypical chemokine receptor 4",TRUE
+"201128_s_at",0.640126343064811,0.110847186354532,-1.66076737363811,-4.67877645762887,-0.384369968917643,"ACLY","ATP citrate lyase",TRUE
+"201127_s_at",0.690015152288705,0.159610852537825,-1.45529372908191,-4.95764710367973,-0.44970315132335,"ACLY","ATP citrate lyase",TRUE
+"210337_s_at",0.725225714005638,0.204024140958871,-1.30877316286786,-5.13815317435062,-0.513256562236675,"ACLY","ATP citrate lyase",TRUE
+"230602_at",0.478691006415319,0.0268172026090557,2.37158534782118,-3.518450189587,1.07317729447822,"ACMSD","aminocarboxymuconate semialdehyde decarboxylase",TRUE
+"237622_at",0.932633693661011,0.702571354802112,-0.38683140098066,-5.8670617198942,-0.233644146557446,"ACO1","aconitase 1",TRUE
+"207071_s_at",0.977281206457742,0.891382345109164,-0.1381338458015,-5.93039412009796,-0.0558765875624125,"ACO1","aconitase 1",TRUE
+"200793_s_at",0.82979599608837,0.401306100674591,-0.855731215404275,-5.58917721520328,-0.339100167509981,"ACO2","aconitase 2",TRUE
+"217307_at",0.980561931836093,0.909181860423156,0.115381747201586,-5.93320131436446,0.0383813107965691,"ACO2","aconitase 2",TRUE
+"240287_at",0.867099100798202,0.498933951601988,0.687448026375106,-5.7120895301256,0.310160785864338,"ACOD1","aconitate decarboxylase 1",TRUE
+"202982_s_at",0.455234810916548,0.0221408256065436,-2.46033924847917,-3.35604043723817,-1.41761328926159,"ACOT1///ACOT2","acyl-CoA thioesterase 1///acyl-CoA thioesterase 2",TRUE
+"214763_at",0.0550194051692779,9.78343344093587e-05,4.73805020474772,1.39119976453102,2.09683416984529,"ACOT11","acyl-CoA thioesterase 11",TRUE
+"1554938_a_at",0.174167700159084,0.00154178631690895,3.60961989747511,-1.03815961047118,2.65115435510839,"ACOT11","acyl-CoA thioesterase 11",TRUE
+"1555321_at",0.515810181619652,0.0361386975110109,2.23070296191142,-3.76922846704537,1.59199943596667,"ACOT11","acyl-CoA thioesterase 11",TRUE
+"216103_at",0.899808883319249,0.593088664676013,0.542205862346575,-5.79749873052329,0.402198138924398,"ACOT11","acyl-CoA thioesterase 11",TRUE
+"238160_at",0.941952420964607,0.739299949389123,0.336984276561748,-5.88452421984594,0.267954949420846,"ACOT12","acyl-CoA thioesterase 12",TRUE
+"204565_at",0.973433731874338,0.871509750028321,-0.163624957356238,-5.92665168486583,-0.0641891159456325,"ACOT13","acyl-CoA thioesterase 13",TRUE
+"229534_at",0.8376750578867,0.422310728405186,-0.817564853841848,-5.6192651625684,-0.873818679310636,"ACOT4","acyl-CoA thioesterase 4",TRUE
+"241949_at",0.697172073261335,0.167553177042555,-1.42688811827873,-4.99387479845831,-1.71612517480735,"ACOT6","acyl-CoA thioesterase 6",TRUE
+"208002_s_at",0.540483367247649,0.0448308815733285,2.12658027313343,-3.94859315975217,0.893531750474692,"ACOT7","acyl-CoA thioesterase 7",TRUE
+"215728_s_at",0.635368778245437,0.106443040026713,1.68285668225405,-4.6471039296418,0.761985178684709,"ACOT7","acyl-CoA thioesterase 7",TRUE
+"204212_at",0.727268508964871,0.207412855240773,-1.2986654769119,-5.15001342079311,-0.465554889472008,"ACOT8","acyl-CoA thioesterase 8",TRUE
+"236514_at",0.835952408568777,0.417049893659376,0.827009175335381,-5.61193937314808,0.353873928419462,"ACOT8","acyl-CoA thioesterase 8",TRUE
+"221641_s_at",0.860085676417428,0.479334013416792,0.719533021396026,-5.6906152765784,0.826768847614852,"ACOT9","acyl-CoA thioesterase 9",TRUE
+"207656_s_at",0.817889575750373,0.370815162975262,0.913496883083982,-5.5412140317976,0.301594034473617,"ACOX1","acyl-CoA oxidase 1",TRUE
+"227962_at",0.841175185633249,0.431070504266995,0.802001125933559,-5.63116544365701,0.27788578022553,"ACOX1","acyl-CoA oxidase 1",TRUE
+"209601_at",0.867580082241907,0.500332283002644,0.68518678061503,-5.71356770324881,0.329755455223699,"ACOX1","acyl-CoA oxidase 1",TRUE
+"209600_s_at",0.980264692225439,0.908011071563921,-0.116876250253838,-5.93303235957309,-0.0410772300275255,"ACOX1","acyl-CoA oxidase 1",TRUE
+"213501_at",0.991215113882097,0.958816856483577,0.0522257026957936,-5.93835509167655,0.0214631434315571,"ACOX1","acyl-CoA oxidase 1",TRUE
+"205364_at",0.218630405352483,0.00265941162540988,-3.38288317134449,-1.5177384640555,-3.4461699512964,"ACOX2","acyl-CoA oxidase 2",TRUE
+"204242_s_at",0.603702127972549,0.078162543215406,-1.84688908307343,-4.40225343919985,-0.790254896383514,"ACOX3","acyl-CoA oxidase 3, pristanoyl",TRUE
+"204241_at",0.617775129514679,0.0888005567899575,-1.77997343338414,-4.50415213910413,-0.70149133563154,"ACOX3","acyl-CoA oxidase 3, pristanoyl",TRUE
+"240189_at",0.217589251556922,0.00262261210381366,3.38871227678686,-1.50549855091096,1.44583623288992,"ACOXL","acyl-CoA oxidase-like",TRUE
+"220845_at",0.627942883677571,0.0993752898461612,1.71998103679689,-4.59316365385433,1.44470493084327,"ACOXL","acyl-CoA oxidase-like",TRUE
+"201630_s_at",0.767338020955751,0.269350732477051,1.13294011017557,-5.3331315465473,0.364505145854675,"ACP1","acid phosphatase 1, soluble",TRUE
+"1554808_at",0.841247691968787,0.431350234572729,0.801507377040957,-5.63153945701689,0.567519283124152,"ACP1","acid phosphatase 1, soluble",TRUE
+"215227_x_at",0.8796702619256,0.534264434899214,0.631360987712536,-5.74737493125093,0.209363212160698,"ACP1","acid phosphatase 1, soluble",TRUE
+"201629_s_at",0.92148618812595,0.665398598143343,0.438319463701078,-5.84653775680415,0.159372262292862,"ACP1","acid phosphatase 1, soluble",TRUE
+"202767_at",0.62110896023334,0.0913979892756661,-1.76469208242492,-4.52703866569514,-0.530807917868424,"ACP2","acid phosphatase 2, lysosomal",TRUE
+"204638_at",0.291178024882244,0.00511251186208824,3.10691265526492,-2.09035608676515,2.06653932905673,"ACP5","acid phosphatase 5, tartrate resistant",TRUE
+"242270_at",0.707898177720919,0.179825651858518,1.38504917395892,-5.04616562768997,0.66552364533619,"ACP6","acid phosphatase 6, lysophosphatidic",TRUE
+"218795_at",0.888750194607196,0.555413291617571,0.59874843913018,-5.76656394340993,0.285515402469684,"ACP6","acid phosphatase 6, lysophosphatidic",TRUE
+"237030_at",0.812505689959838,0.361132538884466,-0.932493180155274,-5.52480951557777,-0.821126033311387,"ACPP","acid phosphatase, prostate",TRUE
+"231711_at",0.931941664456949,0.699135988170427,-0.391543235412681,-5.86528833342069,-0.333938318529892,"ACPP","acid phosphatase, prostate",TRUE
+"204393_s_at",0.990810941805126,0.955936158529577,0.0558826571477104,-5.93816255970534,0.0360133337802999,"ACPP","acid phosphatase, prostate",TRUE
+"241715_x_at",0.805335305758344,0.344658569246137,0.965615775846753,-5.49546530206703,0.236592866070375,"ACPT","acid phosphatase, testicular",TRUE
+"207427_at",0.888972420461865,0.556429834212449,-0.597197530028025,-5.76745202823765,-0.350418097302706,"ACR","acrosin",TRUE
+"223717_s_at",0.597654932724127,0.0737590942545021,1.87692751772065,-4.35563863253662,1.44168969766081,"ACRBP","acrosin binding protein",TRUE
+"223718_at",0.76912869907427,0.274979487112193,1.11934916712929,-5.34717907859439,0.795649435794884,"ACRBP","acrosin binding protein",TRUE
+"230833_at",0.820611742812032,0.381001744132202,0.893863818926738,-5.55784092989467,0.387514721300062,"ACRBP","acrosin binding protein",TRUE
+"238825_at",0.830815768741579,0.404641849214806,-0.849586526700278,-5.59410783563748,-0.300973666773514,"ACRC","acidic repeat containing",TRUE
+"208013_s_at",0.517654151778308,0.0367103952819136,2.22319054163066,-3.78234533990929,0.776448316647088,"ACRV1","acrosomal vesicle protein 1",TRUE
+"207991_x_at",0.686950785936014,0.15543750090045,1.47067986872168,-4.93778178696505,0.902776412134753,"ACRV1","acrosomal vesicle protein 1",TRUE
+"207973_x_at",0.744152356003007,0.234941682232548,1.22094272485063,-5.23858328351812,0.364938881563062,"ACRV1","acrosomal vesicle protein 1",TRUE
+"207990_x_at",0.803583569469174,0.342037282816837,0.970984625256854,-5.49062068079278,0.267192234563461,"ACRV1","acrosomal vesicle protein 1",TRUE
+"206776_x_at",0.916023212016902,0.645623123024178,0.466200142439128,-5.83437478943112,0.132291654472316,"ACRV1","acrosomal vesicle protein 1",TRUE
+"207969_x_at",0.928295253101366,0.685406981725878,0.410465169010051,-5.85795378761291,0.146378779492418,"ACRV1","acrosomal vesicle protein 1",TRUE
+"206466_at",0.747587302711183,0.239346840964677,-1.20915900778904,-5.25160041468497,-0.931533015247514,"ACSBG1","acyl-CoA synthetase bubblegum family member 1",TRUE
+"206465_at",0.778007390824139,0.297254311452074,1.06746710129885,-5.39941746888537,0.797371896463969,"ACSBG1","acyl-CoA synthetase bubblegum family member 1",TRUE
+"221716_s_at",0.951810226174863,0.779309311110085,0.283653845500514,-5.90057042728662,0.119234904480773,"ACSBG2","acyl-CoA synthetase bubblegum family member 2",TRUE
+"218844_at",0.988610271706351,0.945105995277902,0.0696386176462242,-5.93732172605718,0.0433813618714272,"ACSF2","acyl-CoA synthetase family member 2",TRUE
+"1556552_a_at",0.55074985379986,0.0491098180454834,-2.08188003398447,-4.02393426597257,-1.50491115816327,"ACSF3","acyl-CoA synthetase family member 3",TRUE
+"227464_at",0.789503009592599,0.316350223473092,-1.02516070913678,-5.44036937582465,-0.582610921903715,"ACSF3","acyl-CoA synthetase family member 3",TRUE
+"235823_at",0.930908124163614,0.694558361801386,-0.397835828321525,-5.86288701282296,-0.198805326718847,"ACSF3","acyl-CoA synthetase family member 3",TRUE
+"207275_s_at",0.482907175487065,0.027587821068961,-2.35835342232784,-3.54237917230144,-1.58427906103105,"ACSL1","acyl-CoA synthetase long-chain family member 1",TRUE
+"201963_at",0.591331966259927,0.0687395120731941,-1.91314335094509,-4.2987357373736,-1.14611890362883,"ACSL1","acyl-CoA synthetase long-chain family member 1",TRUE
+"201662_s_at",0.79705794499562,0.330138520296731,-0.995716637359648,-5.4679876531014,-0.353762982690855,"ACSL3","acyl-CoA synthetase long-chain family member 3",TRUE
+"201661_s_at",0.8920930097751,0.563059339921424,-0.587118999866573,-5.77316896978935,-0.23899006026309,"ACSL3","acyl-CoA synthetase long-chain family member 3",TRUE
+"201660_at",0.970573392456845,0.860061684821092,-0.178359130037097,-5.92420090601962,-0.0896504656874164,"ACSL3","acyl-CoA synthetase long-chain family member 3",TRUE
+"202422_s_at",0.645740804644555,0.116920056251108,1.63149201933511,-4.72026002455394,2.52049266392479,"ACSL4","acyl-CoA synthetase long-chain family member 4",TRUE
+"1557418_at",0.650059624857948,0.120345743444209,1.61553694302481,-4.74262963201796,1.5790476112168,"ACSL4","acyl-CoA synthetase long-chain family member 4",TRUE
+"1557419_a_at",0.70939075283402,0.182384106803409,1.3766150403108,-5.05655078085087,1.42710823262291,"ACSL4","acyl-CoA synthetase long-chain family member 4",TRUE
+"222592_s_at",0.53309539883286,0.042041698897431,2.15783474924842,-3.89531271872684,3.24244215311085,"ACSL5","acyl-CoA synthetase long-chain family member 5",TRUE
+"218322_s_at",0.678772326285111,0.146369011923209,1.50530622782983,-4.89245922042031,1.17245630209735,"ACSL5","acyl-CoA synthetase long-chain family member 5",TRUE
+"223918_at",0.948668195792872,0.766313118856524,-0.300877611579359,-5.89568688549034,-0.233356226197279,"ACSL6","acyl-CoA synthetase long-chain family member 6",TRUE
+"216409_at",0.954449231029359,0.791087586765685,0.268119657268866,-5.90472994253653,0.096106358263631,"ACSL6","acyl-CoA synthetase long-chain family member 6",TRUE
+"211207_s_at",0.966769992359004,0.845403949202554,-0.197283940481335,-5.9207442797802,-0.173920267333669,"ACSL6","acyl-CoA synthetase long-chain family member 6",TRUE
+"229725_at",0.968733193320334,0.852647098948197,-0.187923432621609,-5.92249736445502,-0.186748309735071,"ACSL6","acyl-CoA synthetase long-chain family member 6",TRUE
+"213683_at",0.989586772349659,0.949274799814766,-0.0643421180530566,-5.93766728527319,-0.051003022626829,"ACSL6","acyl-CoA synthetase long-chain family member 6",TRUE
+"215432_at",0.768852835478002,0.274073959747629,1.12152179830713,-5.34494352632837,0.80087549690891,"ACSM1","acyl-CoA synthetase medium-chain family member 1",TRUE
+"234197_at",0.980326403741224,0.908220405802849,0.11660901677627,-5.93306272996495,0.0589517183148613,"ACSM1","acyl-CoA synthetase medium-chain family member 1",TRUE
+"230554_at",0.956960361976289,0.80497555079391,0.24988891855888,-5.90931476489321,0.24066644409746,"ACSM2A","acyl-CoA synthetase medium-chain family member 2A",TRUE
+"244723_at",0.983364220761052,0.919083585644454,0.102752678599126,-5.93454232126066,0.0830488628018915,"ACSM2A","acyl-CoA synthetase medium-chain family member 2A",TRUE
+"241915_at",0.900077781929876,0.594685135700683,0.539850190398703,-5.79872295293258,0.3646000955718,"ACSM2B","acyl-CoA synthetase medium-chain family member 2B",TRUE
+"241914_s_at",0.525243770035611,0.0392114740211093,-2.19152725763281,-3.83733407228001,-1.55575578882795,"ACSM2B///ACSM2A","acyl-CoA synthetase medium-chain family member 2B///acyl-CoA synthetase medium-chain family member 2A",TRUE
+"214069_at",0.568947452725991,0.058762620311727,1.99262962241871,-4.1712275905127,1.02654182036072,"ACSM2B///ACSM2A","acyl-CoA synthetase medium-chain family member 2B///acyl-CoA synthetase medium-chain family member 2A",TRUE
+"205942_s_at",0.731548533938014,0.215047606340484,-1.27635313290771,-5.17591776899544,-1.3211878035428,"ACSM3","acyl-CoA synthetase medium-chain family member 3",TRUE
+"210377_at",0.87579870142401,0.523684826601107,-0.64793545438494,-5.73724740113158,-0.42458474664329,"ACSM3","acyl-CoA synthetase medium-chain family member 3",TRUE
+"89977_at",0.710578706716869,0.183483313789278,1.37302020787502,-5.0609611679864,0.728156192502285,"ACSM5","acyl-CoA synthetase medium-chain family member 5",TRUE
+"220061_at",0.787784580458053,0.31365912054302,-1.0310115442123,-5.43479471134181,-0.649377726781522,"ACSM5","acyl-CoA synthetase medium-chain family member 5",TRUE
+"1554514_at",0.901191362684597,0.59774494316885,0.535343901154774,-5.80105039101605,0.284177150557822,"ACSM5","acyl-CoA synthetase medium-chain family member 5",TRUE
+"235724_at",0.539609110035715,0.0445167486129376,2.13001124298217,-3.94276823956051,1.56366795875819,"ACSS1","acyl-CoA synthetase short-chain family member 1",TRUE
+"234801_s_at",0.73759219552868,0.224118301346214,-1.25062347871635,-5.20531332330182,-0.888344326370742,"ACSS1","acyl-CoA synthetase short-chain family member 1",TRUE
+"234484_s_at",0.80056683899707,0.336499368318393,0.982420515984589,-5.48021976659973,0.34765994342369,"ACSS1","acyl-CoA synthetase short-chain family member 1",TRUE
+"224882_at",0.88020017258149,0.535391786394821,-0.629605361922302,-5.74843289107418,-0.600731776900528,"ACSS1","acyl-CoA synthetase short-chain family member 1",TRUE
+"234483_at",0.99874554378549,0.99469100816648,0.00672936358215751,-5.93966142444359,0.005470604671026,"ACSS1","acyl-CoA synthetase short-chain family member 1",TRUE
+"234312_s_at",0.986145735582101,0.932296218167492,-0.085926999764108,-5.93608791458276,-0.0387226727986754,"ACSS2","acyl-CoA synthetase short-chain family member 2",TRUE
+"229222_at",0.93523910610914,0.71204549670149,-0.373882671274859,-5.87182618241261,-0.558937003312644,"ACSS3","acyl-CoA synthetase short-chain family member 3",TRUE
+"219616_at",0.947062793209778,0.759796634181144,-0.309548631054887,-5.8931203806351,-0.225870628212858,"ACSS3","acyl-CoA synthetase short-chain family member 3",TRUE
+"203872_at",0.923113737920869,0.670406976148535,0.431314879043333,-5.84947785762889,0.456863175881162,"ACTA1","actin, alpha 1, skeletal muscle",TRUE
+"215787_at",0.843753336849204,0.439288376694993,0.787577511609488,-5.64200200409443,0.538281811151124,"ACTA2","actin, alpha 2, smooth muscle, aorta",TRUE
+"200974_at",0.938034425016976,0.72575488522395,-0.355259394120681,-5.87839787664131,-0.365910800292227,"ACTA2","actin, alpha 2, smooth muscle, aorta",TRUE
+"243140_at",0.943512938262733,0.747465095601372,-0.32602446062538,-5.88804478269984,-0.216410774999229,"ACTA2","actin, alpha 2, smooth muscle, aorta",TRUE
+"1564257_at",0.84899624366548,0.449676925040693,-0.769578894084569,-5.65526453498712,-0.386957936285819,"ACTA2-AS1","ACTA2 antisense RNA 1",TRUE
+"AFFX-HSAC07/X00351_5_at",0.876862063516282,0.525940823245596,0.64438592003896,-5.73943750014341,0.160495703615691,"ACTB","actin beta",TRUE
+"224594_x_at",0.917412255609003,0.650348774568505,0.459504275771035,-5.83736292284819,0.101320932867349,"ACTB","actin beta",TRUE
+"200801_x_at",0.92051722798026,0.662054910996841,0.443008269358902,-5.84454370389157,0.101256721638896,"ACTB","actin beta",TRUE
+"213867_x_at",0.931443166282196,0.69688138625931,0.394640476746181,-5.86411110612648,0.0864898019120073,"ACTB","actin beta",TRUE
+"AFFX-HSAC07/X00351_M_at",0.971216837324271,0.862890248388479,0.174715010389288,-5.9248266429451,0.0418532433828744,"ACTB","actin beta",TRUE
+"AFFX-HSAC07/X00351_3_at",0.990810941805126,0.95481504752208,0.0573060802452462,-5.93808409841818,0.0119941158929358,"ACTB","actin beta",TRUE
+"217211_at",0.906989884330247,0.615489873290568,0.50942633948722,-5.81406758483657,0.200553967201007,"ACTBP9","actin, beta pseudogene 9",TRUE
+"205132_at",0.861659105448003,0.482783959878602,0.713831268068159,-5.69449958645232,0.431077017111436,"ACTC1","actin, alpha, cardiac muscle 1",TRUE
+"212363_x_at",0.820288124919738,0.378715135845906,0.898240499639613,-5.55416331648135,0.213134073802701,"ACTG1///ACTB","actin gamma 1///actin beta",TRUE
+"211995_x_at",0.830635993561085,0.403685762209559,0.85134438125074,-5.59270068037457,0.193327024259879,"ACTG1///ACTB","actin gamma 1///actin beta",TRUE
+"211970_x_at",0.853093296743962,0.459489723004525,0.752807844429995,-5.66736179648158,0.174827606383241,"ACTG1///ACTB","actin gamma 1///actin beta",TRUE
+"201550_x_at",0.857253318078192,0.472171703682158,0.731447272120864,-5.68240389173332,0.170935822672625,"ACTG1///ACTB","actin gamma 1///actin beta",TRUE
+"212988_x_at",0.88113080359582,0.537304504449933,0.626631231634478,-5.75021866469155,0.134891849199981,"ACTG1///ACTB","actin gamma 1///actin beta",TRUE
+"211983_x_at",0.908667507590078,0.620039480282048,0.502838596185502,-5.81727594063656,0.108999277952329,"ACTG1///ACTB","actin gamma 1///actin beta",TRUE
+"213214_x_at",0.910360385238733,0.627386910211166,0.492246922632297,-5.82234882383332,0.105396492201201,"ACTG1///ACTB","actin gamma 1///actin beta",TRUE
+"221607_x_at",0.912241810302154,0.631928250526424,0.485728872462446,-5.82541820545602,0.104278608332606,"ACTG1///ACTB","actin gamma 1///actin beta",TRUE
+"224585_x_at",0.919375181609246,0.657193764317679,0.449843063721795,-5.84159972032814,0.0962978720297709,"ACTG1///ACTB","actin gamma 1///actin beta",TRUE
+"1565912_at",0.710842845257879,0.184543267586958,1.36956985975513,-5.06518526944264,0.930600585010434,"ACTG1P17","actin gamma 1 pseudogene 17",TRUE
+"1565911_at",0.722937902375896,0.199661487357642,1.32197996535431,-5.12253934459965,0.661257019314291,"ACTG1P17","actin gamma 1 pseudogene 17",TRUE
+"1569368_at",0.784789297644843,0.309074882150125,1.04106019508292,-5.42515364767142,0.371897164298189,"ACTG1P17","actin gamma 1 pseudogene 17",TRUE
+"208498_s_at",0.897011777275924,0.582305781716411,-0.558199000280397,-5.78905034508135,-0.757516637623159,"ACTG1P4///AMY2B///AMY2A///AMY1C///AMY1B///AMY1A","actin gamma 1 pseudogene 4///amylase, alpha 2B (pancreatic)///amylase, alpha 2A (pancreatic)///amylase, alpha 1C (salivary)///amylase, alpha 1B (salivary)///amylase, alpha 1A (salivary)",TRUE
+"228023_x_at",0.931838763487749,0.698960156839915,0.391784641787915,-5.86519690590793,0.195115725041324,"ACTG1P4///RNPC3///AMY2B","actin gamma 1 pseudogene 4///RNA binding region (RNP1, RRM) containing 3///amylase, alpha 2B (pancreatic)",TRUE
+"202274_at",0.731054546207485,0.214164961061811,1.27890106394069,-5.17297898833326,1.47559341537638,"ACTG2","actin, gamma 2, smooth muscle, enteric",TRUE
+"241148_at",0.989475734766121,0.948132724873576,0.0657929393040464,-5.93757534520008,0.0344038777018891,"ACTG2","actin, gamma 2, smooth muscle, enteric",TRUE
+"232619_at",0.854040699678541,0.463361011710366,-0.746250580327302,-5.67202306787267,-0.299514417114205,"ACTL10","actin like 10",TRUE
+"202666_s_at",0.726636642789909,0.206408663908003,1.30164727811242,-5.14652271076042,0.381696824587022,"ACTL6A","actin like 6A",TRUE
+"206014_at",0.61760967235709,0.0881015644001151,1.78415141815225,-4.49786975377743,0.488361768125564,"ACTL6B","actin like 6B",TRUE
+"206013_s_at",0.879841194727839,0.53466083136552,0.630743451545114,-5.74774738869166,0.345072274132492,"ACTL6B","actin like 6B",TRUE
+"220501_at",0.836093675511714,0.417381632911143,-0.826411426657089,-5.61240537134655,-0.404069638647973,"ACTL7A","actin like 7A",TRUE
+"220498_at",0.976371465776674,0.886247652079368,-0.144710587059957,-5.92948896095725,-0.056617217398693,"ACTL7B","actin like 7B",TRUE
+"214957_at",0.974451535839172,0.874995983373645,-0.159145527327623,-5.92735501112053,-0.194615005233086,"ACTL8","actin like 8",TRUE
+"243208_x_at",0.860826965444733,0.480803545875652,0.717101402881742,-5.69227540865338,0.274571343330324,"ACTL9","actin like 9",TRUE
+"211160_x_at",0.407616968856903,0.0154920541615847,2.62261989144333,-3.05105789294995,1.40256431085134,"ACTN1","actinin alpha 1",TRUE
+"208637_x_at",0.55937703282623,0.0535082859103969,2.03943326270963,-4.09451613150139,0.968147211468473,"ACTN1","actinin alpha 1",TRUE
+"237401_at",0.675675845619713,0.142292515555449,1.52144511513439,-4.8710463529599,0.596800457834829,"ACTN1","actinin alpha 1",TRUE
+"208636_at",0.763247589514474,0.262945250957378,1.14866239747275,-5.31669456508326,0.47874260567486,"ACTN1","actinin alpha 1",TRUE
+"203863_at",0.737535792093258,0.223878072438115,-1.25129452579171,-5.20455318321003,-1.00272350852711,"ACTN2","actinin alpha 2",TRUE
+"203861_s_at",0.844472871821284,0.441249350731107,-0.784160289503623,-5.64454225811002,-0.765959735487258,"ACTN2","actinin alpha 2",TRUE
+"203862_s_at",0.854400503339099,0.465642941793238,0.74240068934085,-5.67474178269536,0.829625570103279,"ACTN2","actinin alpha 2",TRUE
+"203864_s_at",0.983777183253528,0.920632479484307,0.100778756467246,-5.93473790376856,0.0316494923088433,"ACTN2","actinin alpha 2",TRUE
+"206891_at",0.820536502908875,0.380766116077033,0.894314023892773,-5.55746340103451,0.43673733550057,"ACTN3","actinin alpha 3 (gene/pseudogene)",TRUE
+"200601_at",0.525405708458677,0.0393334122939484,2.1900308868044,-3.8399208245352,1.09881580246045,"ACTN4","actinin alpha 4",TRUE
+"222230_s_at",0.712948021516228,0.18717112679937,-1.36108276747507,-5.07553794231584,-0.446439618869238,"ACTR10","actin-related protein 10 homolog",TRUE
+"200721_s_at",0.947969282616012,0.7636233216805,-0.3044538403657,-5.89463712583459,-0.0995020854554234,"ACTR1A","ARP1 actin-related protein 1 homolog A, centractin alpha",TRUE
+"200720_s_at",0.973071267819624,0.869706315120521,0.165943514532815,-5.92627999508342,0.0595864657952276,"ACTR1A","ARP1 actin-related protein 1 homolog A, centractin alpha",TRUE
+"202135_s_at",0.669423128374382,0.135539590890429,-1.54903550154385,-4.83401957620335,-0.456164191361379,"ACTR1B","ARP1 actin-related protein 1 homolog B, centractin beta",TRUE
+"200728_at",0.683017520100356,0.151535300896767,-1.48537251637369,-4.91865423859187,-0.409832471521499,"ACTR2","ARP2 actin related protein 2 homolog",TRUE
+"234210_x_at",0.778007390824139,0.297314795132685,1.06733009558771,-5.39955248607193,0.424479939928266,"ACTR2","ARP2 actin related protein 2 homolog",TRUE
+"200729_s_at",0.926297908098578,0.679861156910614,-0.418151716932397,-5.85487705339483,-0.105788384496515,"ACTR2","ARP2 actin related protein 2 homolog",TRUE
+"1554390_s_at",0.936599157163462,0.71703411435492,-0.36709072407465,-5.87426128382342,-0.11511670190367,"ACTR2","ARP2 actin related protein 2 homolog",TRUE
+"1558015_s_at",0.962555471240652,0.829214617541394,-0.218272544140025,-5.91650498418897,-0.0748421370758834,"ACTR2","ARP2 actin related protein 2 homolog",TRUE
+"234212_at",0.966051687342135,0.841200557555916,0.202724317516394,-5.91968637536792,0.18645176729488,"ACTR2","ARP2 actin related protein 2 homolog",TRUE
+"200727_s_at",0.99443717604727,0.974426527362744,-0.032421098504592,-5.93917152820439,-0.0110669633954483,"ACTR2","ARP2 actin related protein 2 homolog",TRUE
+"239170_at",0.812896635201594,0.361985069530334,0.930807045273807,-5.52627816379578,0.485506402565331,"ACTR3","ARP3 actin related protein 3 homolog",TRUE
+"228603_at",0.864079461576774,0.491233322436047,0.699965908121581,-5.70382250174707,0.411060049999513,"ACTR3","ARP3 actin related protein 3 homolog",TRUE
+"213101_s_at",0.97689149311934,0.889469466716857,-0.140583199804216,-5.93006192444004,-0.0331549076258959,"ACTR3","ARP3 actin related protein 3 homolog",TRUE
+"200996_at",0.983498417373669,0.919586759816675,0.102111384116411,-5.93460627838895,0.0266996588996289,"ACTR3","ARP3 actin related protein 3 homolog",TRUE
+"213102_at",0.992820830895496,0.966155419348531,0.0429128081752879,-5.93878658936237,0.0134019103680956,"ACTR3","ARP3 actin related protein 3 homolog",TRUE
+"1555487_a_at",0.554642754132296,0.0510548470714372,-2.06270705091376,-4.05593317782686,-0.737263927542758,"ACTR3B","ARP3 actin related protein 3 homolog B",TRUE
+"218868_at",0.593339168375633,0.0704386845856264,-1.90063189210865,-4.31847982785326,-0.699659812308748,"ACTR3B","ARP3 actin related protein 3 homolog B",TRUE
+"224425_x_at",0.951383212308888,0.777593884739006,0.285922161145908,-5.89994360331562,0.0706024212591689,"ACTR3BP2","ACTR3B pseudogene 2",TRUE
+"224426_s_at",0.854343866520736,0.465114894268494,0.743290569768405,-5.67411455162851,0.529208507296154,"ACTR3BP2///ACTR3BP5","ACTR3B pseudogene 2///ACTR3B pseudogene 5",TRUE
+"224424_x_at",0.965707350334601,0.839641129266495,0.204744242529701,-5.91928629569444,0.0695132519827037,"ACTR3BP2///ACTR3BP5","ACTR3B pseudogene 2///ACTR3B pseudogene 5",TRUE
+"223874_at",0.926430328514448,0.680346671196324,0.417477773656782,-5.85514906137045,0.361353488774991,"ACTR3C","ARP3 actin-related protein 3 homolog C",TRUE
+"222147_s_at",0.90415231543826,0.606400801427076,-0.522656219289138,-5.8075014221602,-0.148276062830277,"ACTR5","ARP5 actin-related protein 5 homolog",TRUE
+"219623_at",0.988224361618126,0.943932489560548,0.0711299276225097,-5.93721950153205,0.0253068374480279,"ACTR5","ARP5 actin-related protein 5 homolog",TRUE
+"218395_at",0.731054546207485,0.214099637927298,-1.27908995352403,-5.17276092434667,-0.602772734555538,"ACTR6","ARP6 actin-related protein 6 homolog",TRUE
+"241794_at",0.996045968999879,0.98032420089294,-0.0249423834114001,-5.93938047236435,-0.012920513370914,"ACTR6","ARP6 actin-related protein 6 homolog",TRUE
+"222707_s_at",0.945498722604777,0.754164894397376,-0.317061919543733,-5.89083813570704,-0.0850582932738071,"ACTR8","ARP8 actin-related protein 8 homolog",TRUE
+"218658_s_at",0.956734254923335,0.803512774087227,0.251804924577457,-5.90884799217409,0.0791963756313452,"ACTR8","ARP8 actin-related protein 8 homolog",TRUE
+"237360_at",0.744152356003007,0.234969359485452,1.22086816952964,-5.23866598607087,0.396782915369454,"ACTRT2","actin related protein T2",TRUE
+"223665_at",0.693742297578797,0.162941588546151,1.44324579093317,-4.97308383115161,1.24516014420612,"ACTRT3","actin related protein T3",TRUE
+"203935_at",0.870988083355039,0.511292379851135,-0.667585410462346,-5.72491441363182,-0.219421273928017,"ACVR1","activin A receptor type 1",TRUE
+"213198_at",0.51531387545335,0.0357575428267643,-2.23577189641471,-3.76036290374692,-0.876982424283721,"ACVR1B","activin A receptor type 1B",TRUE
+"208219_at",0.637485146909712,0.108757516011144,1.67115394802927,-4.66392334047374,0.986306492542699,"ACVR1B","activin A receptor type 1B",TRUE
+"208222_at",0.705199235335767,0.176999526410841,1.39447722382762,-5.03449444035861,0.809567600761668,"ACVR1B","activin A receptor type 1B",TRUE
+"208218_s_at",0.780674131139921,0.302404151847746,-1.05587238085573,-5.41078893540522,-0.565900756992603,"ACVR1B","activin A receptor type 1B",TRUE
+"208223_s_at",0.895040806753727,0.572515082480075,-0.572849005104194,-5.78110242704605,-0.218125607514027,"ACVR1B","activin A receptor type 1B",TRUE
+"205209_at",0.944654135079729,0.75119789021731,-0.321027665962653,-5.88961164111011,-0.126726140708744,"ACVR1B","activin A receptor type 1B",TRUE
+"1552519_at",0.163850812837738,0.00130855595713284,3.67738025564632,-0.893653246068628,1.50041984074626,"ACVR1C","activin A receptor type 1C",TRUE
+"1563182_at",0.528235927681883,0.0408676355572815,2.17155440440873,-3.87177092261999,1.55521706775177,"ACVR1C","activin A receptor type 1C",TRUE
+"228416_at",0.661675547246292,0.12906757588261,-1.57656434729008,-4.79655245656987,-0.571706334406321,"ACVR2A","activin A receptor type 2A",TRUE
+"205327_s_at",0.864894115958506,0.493276114545614,-0.696634348854521,-5.70603662491051,-0.243492442314166,"ACVR2A","activin A receptor type 2A",TRUE
+"1559548_at",0.89390639630277,0.569844440514659,-0.576867080919709,-5.77888767796147,-0.46178542189225,"ACVR2B","activin A receptor type 2B",TRUE
+"220028_at",0.950720668053893,0.77512896637882,0.289184220743177,-5.89903348583154,0.112627775804803,"ACVR2B","activin A receptor type 2B",TRUE
+"236126_at",0.987583693727698,0.941433234880432,-0.0743065760898752,-5.93699453541708,-0.0395285304356392,"ACVR2B","activin A receptor type 2B",TRUE
+"215590_x_at",0.884221189678062,0.543063179297905,-0.617711042169262,-5.75552581834322,-0.292787015504176,"ACVR2B-AS1","ACVR2B antisense RNA 1",TRUE
+"226950_at",0.864670735413289,0.492059721292164,-0.698617191596128,-5.70472006011324,-0.299773227279048,"ACVRL1","activin A receptor like type 1",TRUE
+"210838_s_at",0.865345395265289,0.494796345868056,0.694160150419374,-5.70767443148559,0.501512819415447,"ACVRL1","activin A receptor like type 1",TRUE
+"238849_at",0.841550580403629,0.432719317023836,-0.799093681013278,-5.63336470896988,-0.478335518562495,"ACY1","aminoacylase 1",TRUE
+"1554974_at",0.698480416742743,0.169784646992089,-1.41910243303573,-5.00370238900468,-1.0897697762734,"ACY3","aminoacylase 3",TRUE
+"230481_at",0.955730092376044,0.797440998399179,0.259768386755886,-5.90686998860294,0.104834403443093,"ACY3","aminoacylase 3",TRUE
+"205260_s_at",0.777547149102231,0.296540965843717,1.06908445418738,-5.39782241814269,0.558130211223435,"ACYP1","acylphosphatase 1",TRUE
+"204639_at",0.454704057902876,0.0220386969079583,2.46246532752549,-3.3521103181323,2.47327268371877,"ADA","adenosine deaminase",TRUE
+"216705_s_at",0.467182928024826,0.0244806417702995,2.41396672398234,-3.44130495940665,3.0189146685508,"ADA","adenosine deaminase",TRUE
+"240299_at",0.818895116503733,0.372872186721799,0.909503838006131,-5.54462269455612,0.593707948108556,"ADAD1","adenosine deaminase domain containing 1",TRUE
+"231448_at",0.94943075115007,0.771682727944361,-0.293750339980447,-5.89774233462088,-0.0747516779428192,"ADAD1","adenosine deaminase domain containing 1",TRUE
+"236463_at",0.528176582660474,0.0408105838897473,2.17223013527464,-3.87060902799282,1.16710493500207,"ADAD2","adenosine deaminase domain containing 2",TRUE
+"236018_at",0.73148417124022,0.21466204515199,1.27746513896585,-5.17463579718526,0.589308139138272,"ADAL","adenosine deaminase like",TRUE
+"238424_at",0.859696489664632,0.477906662206138,0.7218990099001,-5.68899482139468,0.470077421613667,"ADAL","adenosine deaminase like",TRUE
+"239711_at",0.954577684533304,0.792085154775657,0.266807125017349,-5.90507073846101,0.178737700801939,"ADAL","adenosine deaminase like",TRUE
+"202604_x_at",0.715352956634026,0.190984500502932,1.34893251034032,-5.09026543991244,0.64387373445644,"ADAM10","ADAM metallopeptidase domain 10",TRUE
+"202603_at",0.756198431607818,0.251070327004604,1.17857455572777,-5.28487387027623,0.494444672454303,"ADAM10","ADAM metallopeptidase domain 10",TRUE
+"214895_s_at",0.797963285726587,0.332218349757554,0.991349856388294,-5.47202147578165,0.522428749911192,"ADAM10","ADAM metallopeptidase domain 10",TRUE
+"207880_at",0.697589104334815,0.168099210425807,-1.42497533666739,-4.99629331925698,-0.49070485314514,"ADAM11","ADAM metallopeptidase domain 11",TRUE
+"239837_at",0.733779920293333,0.21792220250307,-1.26811044707105,-5.18539059504365,-0.877951651592009,"ADAM11","ADAM metallopeptidase domain 11",TRUE
+"213790_at",0.121574729544071,0.000682641828441333,3.94473534548717,-0.319823429217831,3.17145089402863,"ADAM12","ADAM metallopeptidase domain 12",TRUE
+"226777_at",0.255831879596455,0.00373863140004696,3.23972972366689,-1.81655907853776,2.21649888073775,"ADAM12","ADAM metallopeptidase domain 12",TRUE
+"202952_s_at",0.285319386651973,0.00483751388068365,3.13047612246913,-2.04204905120984,2.83083827804053,"ADAM12","ADAM metallopeptidase domain 12",TRUE
+"204943_at",0.686108994812404,0.154519594786552,1.47410880527775,-4.93333158100481,0.957014698069818,"ADAM12","ADAM metallopeptidase domain 12",TRUE
+"215613_at",0.878647293269438,0.531617681060101,0.63549065848243,-5.74487517139528,0.461484046123042,"ADAM12","ADAM metallopeptidase domain 12",TRUE
+"1555896_a_at",0.928447573816529,0.68570119854982,-0.410058088536064,-5.85811516611592,-0.177005237873178,"ADAM15","ADAM metallopeptidase domain 15",TRUE
+"217007_s_at",0.971216837324271,0.862644346651098,-0.175031715843412,-5.92477277198234,-0.0978141338727916,"ADAM15","ADAM metallopeptidase domain 15",TRUE
+"205745_x_at",0.621368540129578,0.0918500327631869,1.76207081782911,-4.53094992211583,0.735909058328495,"ADAM17","ADAM metallopeptidase domain 17",TRUE
+"205746_s_at",0.683019114815084,0.151666844326117,1.48487224430104,-4.91930803678,0.831553824281816,"ADAM17","ADAM metallopeptidase domain 17",TRUE
+"213532_at",0.76912869907427,0.275015557329861,1.11926273209048,-5.3472679374916,0.488009501652392,"ADAM17","ADAM metallopeptidase domain 17",TRUE
+"207597_at",0.8288884913487,0.399628597532183,0.858833679564999,-5.58667516113205,0.311010797626127,"ADAM18","ADAM metallopeptidase domain 18",TRUE
+"1568970_at",0.972624640038332,0.867544904439295,0.168723525978842,-5.92582745300515,0.109576697661423,"ADAM18","ADAM metallopeptidase domain 18",TRUE
+"209765_at",0.271305453183858,0.00426923438826133,3.18357261295728,-1.93276368976135,1.72963057504725,"ADAM19","ADAM metallopeptidase domain 19",TRUE
+"221128_at",0.932269331146744,0.701314994056161,0.38855354398779,-5.86641601284899,0.221838418441238,"ADAM19","ADAM metallopeptidase domain 19",TRUE
+"207664_at",0.769258076576208,0.27601973579712,1.11685973247011,-5.34973589059402,0.92922640074813,"ADAM2","ADAM metallopeptidase domain 2",TRUE
+"207423_s_at",0.708894565317004,0.1808586149848,1.38163254797575,-5.0503789446804,0.775809870032085,"ADAM20","ADAM metallopeptidase domain 20",TRUE
+"207422_at",0.746728626876669,0.238611720899173,-1.21111399489916,-5.24944836519283,-0.613478819230142,"ADAM20","ADAM metallopeptidase domain 20",TRUE
+"207665_at",0.774230543658252,0.28699034208029,1.0910119958009,-5.37598443885932,0.412292593841141,"ADAM21","ADAM metallopeptidase domain 21",TRUE
+"1552579_a_at",0.868055236465056,0.50197329517853,0.682537659273793,-5.71529350943614,0.504750230319961,"ADAM21","ADAM metallopeptidase domain 21",TRUE
+"208227_x_at",0.391240007651669,0.0131526420175332,-2.69581924127153,-2.91037213868976,-1.93177685322028,"ADAM22","ADAM metallopeptidase domain 22",TRUE
+"244194_at",0.523568161693293,0.0389360428979411,-2.1949228191236,-3.83146019342843,-1.74291781571271,"ADAM22","ADAM metallopeptidase domain 22",TRUE
+"208226_x_at",0.815775199549376,0.36665031010861,-0.921626858973246,-5.5342313344606,-0.816381955666072,"ADAM22","ADAM metallopeptidase domain 22",TRUE
+"206615_s_at",0.87052412550512,0.509672570307168,-0.670173309335215,-5.72326384783252,-0.565396460983471,"ADAM22","ADAM metallopeptidase domain 22",TRUE
+"206616_s_at",0.887948692739633,0.553418819136788,-0.601795661353558,-5.76481255708121,-0.340867346363824,"ADAM22","ADAM metallopeptidase domain 22",TRUE
+"1555024_at",0.939976205834042,0.730240962734259,0.349193382264438,-5.88046682689071,0.148096219138225,"ADAM22","ADAM metallopeptidase domain 22",TRUE
+"213411_at",0.983364220761052,0.919050226554255,-0.102795196250645,-5.93453806678087,-0.0738847339248325,"ADAM22","ADAM metallopeptidase domain 22",TRUE
+"208237_x_at",0.993474831312851,0.969443346018294,-0.0387416252305998,-5.93895246755012,-0.0281566509124085,"ADAM22","ADAM metallopeptidase domain 22",TRUE
+"213808_at",0.348854934125219,0.00911724171442407,2.85734599433762,-2.59379262650549,2.03746188430068,"ADAM23","ADAM metallopeptidase domain 23",TRUE
+"244463_at",0.68033297785336,0.147810850012354,1.49968598632276,-4.89987318394963,1.12166673150374,"ADAM23","ADAM metallopeptidase domain 23",TRUE
+"1559268_at",0.758920166935337,0.256212832794146,1.16549479094828,-5.29887638287482,0.445916159843033,"ADAM23","ADAM metallopeptidase domain 23",TRUE
+"206046_at",0.919481699308214,0.657889786500912,0.448863124965156,-5.84202452887854,0.314585262285295,"ADAM23","ADAM metallopeptidase domain 23",TRUE
+"205997_at",0.531252719138635,0.0416676492888279,2.1621677236973,-3.88788773287883,1.72909295618946,"ADAM28","ADAM metallopeptidase domain 28",TRUE
+"208269_s_at",0.67842163564685,0.145799030891396,1.50754048272472,-4.88950572567972,0.741400444497675,"ADAM28","ADAM metallopeptidase domain 28",TRUE
+"208268_at",0.764484986311369,0.264615973771242,1.14453466359763,-5.3210292491935,0.619570978837761,"ADAM28","ADAM metallopeptidase domain 28",TRUE
+"241446_at",0.812302873476553,0.359912208531417,-0.934911399400641,-5.52269894718994,-0.96877035866231,"ADAM28","ADAM metallopeptidase domain 28",TRUE
+"221446_at",0.700471084903438,0.172238377054263,1.41063533486597,-5.01433995807837,0.658371715665223,"ADAM30","ADAM metallopeptidase domain 30",TRUE
+"243520_x_at",0.917906507115144,0.651385356045547,-0.458038382051655,-5.83801144952145,-0.454530844916818,"ADAM30","ADAM metallopeptidase domain 30",TRUE
+"1552266_at",0.994057527155985,0.972336716470998,-0.0350715757271916,-5.93908440334424,-0.0210546739631692,"ADAM32","ADAM metallopeptidase domain 32",TRUE
+"232570_s_at",0.960364513710223,0.820196085371722,0.230007608824022,-5.91394893604887,0.107438698061669,"ADAM33","ADAM metallopeptidase domain 33",TRUE
+"233868_x_at",0.992411625661333,0.964676738345183,-0.0447889663471594,-5.93870645425598,-0.0341878958204616,"ADAM33","ADAM metallopeptidase domain 33",TRUE
+"217090_at",0.791838559691106,0.322640695984739,1.01161909747898,-5.45316179991663,0.754984794614977,"ADAM3A","ADAM metallopeptidase domain 3A (pseudogene)",TRUE
+"216276_s_at",0.986342822130003,0.933814451741503,-0.0839953201175437,-5.93624773037501,-0.0618497716444026,"ADAM3A","ADAM metallopeptidase domain 3A (pseudogene)",TRUE
+"217237_at",0.948668195792872,0.766330312358076,-0.300854764830726,-5.89569355235809,-0.192702789714896,"ADAM3B","ADAM metallopeptidase domain 3B (pseudogene)",TRUE
+"217003_s_at",0.813021318305036,0.362222893423965,0.930337151864508,-5.52668701243406,0.411800432157264,"ADAM5","ADAM metallopeptidase domain 5 (pseudogene)",TRUE
+"216998_s_at",0.887747346625205,0.552865512261332,-0.60264204021451,-5.76432457863527,-0.317010083822395,"ADAM5","ADAM metallopeptidase domain 5 (pseudogene)",TRUE
+"237909_at",0.849935057946582,0.451542842410603,0.766372984094543,-5.65759649042209,0.530259705797071,"ADAM6","ADAM metallopeptidase domain 6 (pseudogene)",TRUE
+"211239_s_at",0.739189560382301,0.226301962056688,1.24454876580124,-5.21217861804048,0.920061802659892,"ADAM7","ADAM metallopeptidase domain 7",TRUE
+"211238_at",0.874879869985496,0.521695626906943,0.65107217656662,-5.7353023970151,0.530721393448526,"ADAM7","ADAM metallopeptidase domain 7",TRUE
+"239079_at",0.995025131654789,0.976745783885175,0.0294798964774083,-5.93926020043742,0.0156757342478215,"ADAM7","ADAM metallopeptidase domain 7",TRUE
+"205180_s_at",0.536559328842429,0.04344036624425,2.1419354192758,-3.92247789594689,2.01157923742215,"ADAM8","ADAM metallopeptidase domain 8",TRUE
+"205179_s_at",0.617775129514679,0.0884416400983571,1.78211518146861,-4.50093296144489,1.60460818347312,"ADAM8","ADAM metallopeptidase domain 8",TRUE
+"1555326_a_at",0.726636642789909,0.206211801621668,1.30223315115914,-5.14583604811453,0.842479011914573,"ADAM9","ADAM metallopeptidase domain 9",TRUE
+"202381_at",0.731290024721605,0.214351237973268,1.27836266592566,-5.17360039241432,0.83830100568979,"ADAM9","ADAM metallopeptidase domain 9",TRUE
+"1570042_a_at",0.762192206662119,0.261551042744614,1.15212180255683,-5.31305114743518,0.828017981666613,"ADAM9","ADAM metallopeptidase domain 9",TRUE
+"206134_at",0.828070400350931,0.397853966405955,0.862124905052684,-5.58401166190054,0.427126682129712,"ADAMDEC1","ADAM like decysin 1",TRUE
+"222162_s_at",0.832605695407954,0.40929194317486,-0.841074491481329,-5.60088329757896,-1.63454352219691,"ADAMTS1","ADAM metallopeptidase with thrombospondin type 1 motif 1",TRUE
+"222486_s_at",0.849935057946582,0.452269748318795,-0.765126226093031,-5.65850088934037,-1.41992991115446,"ADAMTS1","ADAM metallopeptidase with thrombospondin type 1 motif 1",TRUE
+"230341_x_at",0.812896635201594,0.361856673785469,-0.931060816050576,-5.52605728193897,-0.406390764459975,"ADAMTS10","ADAM metallopeptidase with thrombospondin type 1 motif 10",TRUE
+"232133_at",0.985498770484702,0.930247466939078,0.088534200402641,-5.9358664525532,0.0421068184025168,"ADAMTS10","ADAM metallopeptidase with thrombospondin type 1 motif 10",TRUE
+"226997_at",0.304824368772306,0.00600995976557644,3.03771931157757,-2.23148607712231,3.52844280416152,"ADAMTS12","ADAM metallopeptidase with thrombospondin type 1 motif 12",TRUE
+"221421_s_at",0.49018628652281,0.0293170399072627,2.32985894086179,-3.59365122134069,0.842857155656167,"ADAMTS12","ADAM metallopeptidase with thrombospondin type 1 motif 12",TRUE
+"223844_at",0.81836001261482,0.371462270149297,0.91223915469762,-5.54228917781791,0.70289398419026,"ADAMTS13","ADAM metallopeptidase with thrombospondin type 1 motif 13",TRUE
+"220208_at",0.871744769522775,0.513579511959741,0.663939138001625,-5.72722962945346,0.325469921226031,"ADAMTS13","ADAM metallopeptidase with thrombospondin type 1 motif 13",TRUE
+"230167_at",0.662575055303091,0.130277553260938,1.57133210846654,-4.80371350760594,1.05357259555963,"ADAMTS14","ADAM metallopeptidase with thrombospondin type 1 motif 14",TRUE
+"229004_at",0.928400492219173,0.685598505237152,-0.410200167717397,-5.85805885970675,-0.597743533991557,"ADAMTS15","ADAM metallopeptidase with thrombospondin type 1 motif 15",TRUE
+"1553427_at",0.96200396340887,0.827574096931763,-0.220404836631824,-5.9160504451162,-0.127756707908883,"ADAMTS15","ADAM metallopeptidase with thrombospondin type 1 motif 15",TRUE
+"238125_at",0.358427723880268,0.0101836733666143,2.80890263091311,-2.68957572613948,1.34780269833881,"ADAMTS16","ADAM metallopeptidase with thrombospondin type 1 motif 16",TRUE
+"1552725_s_at",0.715644762361881,0.191407361208511,1.3475969788694,-5.09187751733198,0.730882230751151,"ADAMTS17","ADAM metallopeptidase with thrombospondin type 1 motif 17",TRUE
+"1552726_at",0.734042693548791,0.218324525180541,-1.2669634963001,-5.18670456048369,-0.833879586731192,"ADAMTS17","ADAM metallopeptidase with thrombospondin type 1 motif 17",TRUE
+"1552727_s_at",0.769258076576208,0.276078351343239,-1.1167196624669,-5.34987960181318,-0.578851237808582,"ADAMTS17","ADAM metallopeptidase with thrombospondin type 1 motif 17",TRUE
+"230040_at",0.786866550604083,0.312789348163313,1.03291009390458,-5.43297962704683,0.551282989840982,"ADAMTS18","ADAM metallopeptidase with thrombospondin type 1 motif 18",TRUE
+"1553234_at",0.953516309041226,0.785589312429283,-0.275362624381488,-5.90281945780187,-0.125717182217812,"ADAMTS18","ADAM metallopeptidase with thrombospondin type 1 motif 18",TRUE
+"1553179_at",0.772430642757484,0.282909207235912,-1.10054245869526,-5.36636975003295,-1.90044883785179,"ADAMTS19","ADAM metallopeptidase with thrombospondin type 1 motif 19",TRUE
+"1553180_at",0.785106775499404,0.31036832244631,-1.03821439038755,-5.42789257257903,-1.33718499318827,"ADAMTS19","ADAM metallopeptidase with thrombospondin type 1 motif 19",TRUE
+"214454_at",0.835952408568777,0.416065948292643,0.828783874937718,-5.61055397936197,0.605939424705067,"ADAMTS2","ADAM metallopeptidase with thrombospondin type 1 motif 2",TRUE
+"226311_at",0.943824539742785,0.74836120086325,0.324824148228532,-5.88842335401515,0.0848604837169455,"ADAMTS2","ADAM metallopeptidase with thrombospondin type 1 motif 2",TRUE
+"214535_s_at",0.983212176432519,0.91829409765938,-0.103758968549708,-5.93444115637182,-0.069761123783298,"ADAMTS2","ADAM metallopeptidase with thrombospondin type 1 motif 2",TRUE
+"1553409_at",0.829104291742545,0.400366008424082,0.857468844024323,-5.58777690321258,0.681931883261985,"ADAMTS20","ADAM metallopeptidase with thrombospondin type 1 motif 20",TRUE
+"220717_at",0.888312537451395,0.554202519371559,0.60059761385847,-5.7655021573489,0.313876430485875,"ADAMTS20","ADAM metallopeptidase with thrombospondin type 1 motif 20",TRUE
+"214913_at",0.835288731225683,0.414367375528746,0.83185376057202,-5.6081509577826,0.444082193791519,"ADAMTS3","ADAM metallopeptidase with thrombospondin type 1 motif 3",TRUE
+"1555380_at",0.933649615158206,0.706419117816674,0.381564496048995,-5.86901896603585,0.117399321595878,"ADAMTS4","ADAM metallopeptidase with thrombospondin type 1 motif 4",TRUE
+"235368_at",0.573496623084053,0.0602918809234045,1.97970657805575,-4.19219827571232,1.3442950408422,"ADAMTS5","ADAM metallopeptidase with thrombospondin type 1 motif 5",TRUE
+"1558636_s_at",0.740476003158683,0.229267698218804,1.2363695580508,-5.22137686037029,1.25704259568915,"ADAMTS5","ADAM metallopeptidase with thrombospondin type 1 motif 5",TRUE
+"229357_at",0.856218013689995,0.469678841638597,0.735618958531798,-5.67949846499097,0.645779940819538,"ADAMTS5","ADAM metallopeptidase with thrombospondin type 1 motif 5",TRUE
+"219935_at",0.861113073516266,0.481257190054645,-0.71635163770333,-5.69278621520155,-0.392210074086313,"ADAMTS5","ADAM metallopeptidase with thrombospondin type 1 motif 5",TRUE
+"237411_at",0.406164654174876,0.0153723761421049,2.62610341616963,-3.04440468273663,3.24502195511989,"ADAMTS6","ADAM metallopeptidase with thrombospondin type 1 motif 6",TRUE
+"220866_at",0.627092759817312,0.0984459696210165,1.72502831013711,-4.58576214099643,1.05282582999864,"ADAMTS6","ADAM metallopeptidase with thrombospondin type 1 motif 6",TRUE
+"1570351_at",0.641112145892678,0.111620903467133,1.65696355721395,-4.68419838730588,1.05424842701686,"ADAMTS6","ADAM metallopeptidase with thrombospondin type 1 motif 6",TRUE
+"220706_at",0.640337040581689,0.111121852156992,1.65941448102211,-4.68070594587992,1.00648402932581,"ADAMTS7","ADAM metallopeptidase with thrombospondin type 1 motif 7",TRUE
+"220705_s_at",0.69227042558579,0.161621438296978,1.44799704797313,-4.96700863918309,0.890170592819116,"ADAMTS7","ADAM metallopeptidase with thrombospondin type 1 motif 7",TRUE
+"228911_at",0.948668195792872,0.766390188009714,-0.300775203257732,-5.89571676515763,-0.0975044843238426,"ADAMTS7","ADAM metallopeptidase with thrombospondin type 1 motif 7",TRUE
+"220676_at",0.817850153113874,0.370474526605785,-0.914159534727301,-5.54064702667902,-0.5455489914419,"ADAMTS8","ADAM metallopeptidase with thrombospondin type 1 motif 8",TRUE
+"235649_at",0.911980931431396,0.631189216758947,0.486788125416593,-5.82492211903229,0.275607559411481,"ADAMTS8","ADAM metallopeptidase with thrombospondin type 1 motif 8",TRUE
+"220677_s_at",0.974670398319743,0.876260886690019,-0.157521093124646,-5.92760525597974,-0.0907117293650144,"ADAMTS8","ADAM metallopeptidase with thrombospondin type 1 motif 8",TRUE
+"226814_at",0.55937703282623,0.0537152863818659,2.03751347287926,-4.09768588630751,2.12488167802459,"ADAMTS9","ADAM metallopeptidase with thrombospondin type 1 motif 9",TRUE
+"1554697_at",0.697713925841949,0.168670176359309,1.42298053926148,-4.99881270755409,1.75082280905923,"ADAMTS9","ADAM metallopeptidase with thrombospondin type 1 motif 9",TRUE
+"220287_at",0.721809763133485,0.197939471354854,1.32725492536461,-5.1162660409332,0.454193617307343,"ADAMTS9","ADAM metallopeptidase with thrombospondin type 1 motif 9",TRUE
+"233785_at",0.9116561917482,0.630534512594179,0.487726981219086,-5.82448153599476,0.412659640772283,"ADAMTS9","ADAM metallopeptidase with thrombospondin type 1 motif 9",TRUE
+"233928_at",0.919177722942441,0.655893150562715,-0.451675415581554,-5.84080294879615,-0.144256635860687,"ADAMTS9-AS1","ADAMTS9 antisense RNA 1",TRUE
+"241369_at",0.957105919915331,0.805704796631823,0.24893407936926,-5.90954605738487,0.117549280272013,"ADAMTS9-AS1","ADAMTS9 antisense RNA 1",TRUE
+"1556364_at",0.442366253594105,0.0205345322656029,2.49488757694328,-3.2919540994633,1.92849707915208,"ADAMTS9-AS2","ADAMTS9 antisense RNA 2",TRUE
+"1559296_at",0.855170733355621,0.467462052268851,-0.739339651387228,-5.67689391055492,-0.623811059502057,"ADAMTS9-AS2","ADAMTS9 antisense RNA 2",TRUE
+"1562295_at",0.895213601869362,0.572867717836761,0.572319165235638,-5.78139335378909,0.452351605635733,"ADAMTS9-AS2","ADAMTS9 antisense RNA 2",TRUE
+"233113_at",0.915939421175188,0.645234267573513,-0.466752079551392,-5.8341265903197,-0.263383270298922,"ADAMTS9-AS2","ADAMTS9 antisense RNA 2",TRUE
+"234078_at",0.932091525948902,0.69978556856353,0.390651603830574,-5.8656255385682,0.372601582036512,"ADAMTS9-AS2","ADAMTS9 antisense RNA 2",TRUE
+"224371_at",0.62110896023334,0.0912352629783681,1.76563840912919,-4.52562557782646,0.699777836049778,"ADAMTSL1","ADAMTS like 1",TRUE
+"237217_at",0.876763265334889,0.525785348766353,0.64463027253684,-5.73928710253474,0.51850456477172,"ADAMTSL1","ADAMTS like 1",TRUE
+"229585_at",0.910165867297668,0.626534611496213,0.4934726063043,-5.82176717845353,0.435330358073469,"ADAMTSL1","ADAMTS like 1",TRUE
+"1552457_a_at",0.942373096422033,0.741178379375222,0.334459238902022,-5.88534553322243,0.224891135934794,"ADAMTSL1","ADAMTS like 1",TRUE
+"239909_at",0.965255754814725,0.838178791366903,-0.206639198416488,-5.91890737676421,-0.135890454312122,"ADAMTSL1","ADAMTS like 1",TRUE
+"1552808_at",0.983567332578112,0.920012915823939,0.10156828345138,-5.93466012969178,0.0726478834106401,"ADAMTSL1","ADAMTS like 1",TRUE
+"206629_at",0.817517099085723,0.369952173645581,0.915176471960341,-5.5397761358271,0.266910575689956,"ADAMTSL2","ADAMTS like 2",TRUE
+"1559748_at",0.774230543658252,0.286684575941902,-1.0917226299488,-5.37527009293589,-0.548296134265842,"ADAMTSL3","ADAMTS like 3",TRUE
+"213974_at",0.993892931327222,0.971364868707669,-0.0363042428621279,-5.93904155288236,-0.030451213990772,"ADAMTSL3","ADAMTS like 3",TRUE
+"226071_at",0.308621629697291,0.00626012469639276,3.0202049294563,-2.26703131607071,2.18588867829194,"ADAMTSL4","ADAMTS like 4",TRUE
+"220578_at",0.420127229072219,0.0174190981708156,2.56975468357356,-3.15149255818796,1.61974936813592,"ADAMTSL4","ADAMTS like 4",TRUE
+"242200_at",0.308621629697291,0.0063469616234178,3.01428233666742,-2.27903433943739,1.73439728132603,"ADAMTSL5","ADAMTS like 5",TRUE
+"219150_s_at",0.62986301194198,0.100745021532807,1.7126146880863,-4.60393686983456,1.39965920539617,"ADAP1","ArfGAP with dual PH domains 1",TRUE
+"90265_at",0.712948021516228,0.187079313786076,1.36137770078259,-5.07517907857387,0.752184297865346,"ADAP1","ArfGAP with dual PH domains 1",TRUE
+"219358_s_at",0.860973066016709,0.48097963106382,0.71681032736532,-5.69247377549558,0.232364615262123,"ADAP2","ArfGAP with dual PH domains 2",TRUE
+"222876_s_at",0.919485127002411,0.657933214474946,0.448801996954893,-5.84205099808383,0.334388639858822,"ADAP2","ArfGAP with dual PH domains 2",TRUE
+"201786_s_at",0.933314818367461,0.705001012486995,-0.383504344120292,-5.86830117204545,-0.131817380263103,"ADAR","adenosine deaminase, RNA specific",TRUE
+"203865_s_at",0.61760967235709,0.0881523661596178,-1.78384680792537,-4.49832815576577,-1.52377261055542,"ADARB1","adenosine deaminase, RNA specific B1",TRUE
+"234799_at",0.851733415458562,0.456359471822939,0.758134137684455,-5.66354715883714,0.471354625317712,"ADARB1","adenosine deaminase, RNA specific B1",TRUE
+"207999_s_at",0.854116828440652,0.463593284669137,0.745858192903494,-5.67230077382884,0.264474174915482,"ADARB1","adenosine deaminase, RNA specific B1",TRUE
+"209979_at",0.946257232656659,0.756386568181877,0.314095790579596,-5.89174560689768,0.0869403123485113,"ADARB1","adenosine deaminase, RNA specific B1",TRUE
+"234539_at",0.967489765978409,0.847621898127696,-0.194415751627773,-5.92129047000602,-0.128460501845975,"ADARB1","adenosine deaminase, RNA specific B1",TRUE
+"220648_at",0.974982245454858,0.877806682011427,-0.155536515889085,-5.92790750499571,-0.0927304646612654,"ADARB2","adenosine deaminase, RNA specific B2 (inactive)",TRUE
+"237437_s_at",0.976374806321545,0.88737156837538,-0.143270476995188,-5.92969075625959,-0.0794143637694797,"ADARB2","adenosine deaminase, RNA specific B2 (inactive)",TRUE
+"1561127_at",0.7717895132349,0.281541279270181,1.1037591664084,-5.36310783239974,0.32068440078349,"ADARB2-AS1","ADARB2 antisense RNA 1",TRUE
+"219384_s_at",0.769318800953904,0.276687423904116,-1.11526547990598,-5.35137064338255,-0.477848546202974,"ADAT1","adenosine deaminase, tRNA specific 1",TRUE
+"227213_at",0.762252900774908,0.261794965206191,1.15151558435508,-5.31369030759447,0.413343670917325,"ADAT2","adenosine deaminase, tRNA specific 2",TRUE
+"236817_at",0.994083192910649,0.972476044783877,-0.0348948598275011,-5.93909042512603,-0.0117334158788154,"ADAT2","adenosine deaminase, tRNA specific 2",TRUE
+"1553967_at",0.774230543658252,0.286500548378919,-1.09215059395916,-5.37483969372649,-0.348947136486518,"ADAT3","adenosine deaminase, tRNA specific 3",TRUE
+"1553968_a_at",0.78969417320323,0.317782880260057,-1.02206014827796,-5.44331197071027,-0.267722338980526,"ADAT3","adenosine deaminase, tRNA specific 3",TRUE
+"230634_x_at",0.834257102482644,0.412105798876471,-0.83595355723143,-5.60492879533872,-0.389927675661747,"ADAT3///SCAMP4","adenosine deaminase, tRNA specific 3///secretory carrier membrane protein 4",TRUE
+"227482_at",0.929972194057784,0.690707149762636,-0.40314254325795,-5.86083260991914,-0.223159778477731,"ADCK1","aarF domain containing kinase 1",TRUE
+"44120_at",0.439525352736035,0.0202177642822337,-2.50199650489701,-3.27870890625437,-0.880560106958951,"ADCK2","aarF domain containing kinase 2",TRUE
+"221894_at",0.463552233135475,0.0236763547457344,-2.42942474342079,-3.41298030046752,-0.85112284274873,"ADCK2","aarF domain containing kinase 2",TRUE
+"221893_s_at",0.743553048228796,0.234268156872022,-1.2227590795311,-5.23656709275427,-0.334871998955787,"ADCK2","aarF domain containing kinase 2",TRUE
+"222117_s_at",0.908367146600979,0.619181112792143,-0.504079762376512,-5.81667458419951,-0.234684503125556,"ADCK2","aarF domain containing kinase 2",TRUE
+"228524_at",0.609045683857105,0.0815113532398698,1.82501544918834,-4.43586034598897,0.970937426378876,"ADCK5","aarF domain containing kinase 5",TRUE
+"213245_at",0.682504456039784,0.150074502818111,-1.49095197158547,-4.91135051866605,-1.61572378480498,"ADCY1","adenylate cyclase 1",TRUE
+"232062_at",0.83949628091616,0.426066434369319,-0.81086758218673,-5.62441231419726,-0.595300678825977,"ADCY1","adenylate cyclase 1",TRUE
+"235049_at",0.841550580403629,0.432869733686846,-0.798828784385819,-5.63356471033431,-1.02438158345555,"ADCY1","adenylate cyclase 1",TRUE
+"215348_at",0.980009054680439,0.905752228180165,-0.119760420385648,-5.93270016297524,-0.0509256990586797,"ADCY1","adenylate cyclase 1",TRUE
+"215340_at",0.99691938672319,0.984398681738657,0.0197764981556847,-5.93949298734239,0.00998538775946489,"ADCY1","adenylate cyclase 1",TRUE
+"214547_at",0.534256384815859,0.0423887370339496,2.15384572661911,-3.90214008230077,1.70690249842572,"ADCY10","adenylate cyclase 10, soluble",TRUE
+"217305_s_at",0.825648186672984,0.393194156547414,0.870812286555253,-5.57693569092113,0.444159464878116,"ADCY10","adenylate cyclase 10, soluble",TRUE
+"233959_at",0.820293495506061,0.379258293480363,0.897199299829206,-5.55503971650746,0.560458887106902,"ADCY10P1","adenylate cyclase 10, soluble pseudogene 1",TRUE
+"236832_at",0.823531358962779,0.390627582744474,0.875625680960544,-5.57298674662647,0.404137461369845,"ADCY10P1","adenylate cyclase 10, soluble pseudogene 1",TRUE
+"213217_at",0.722362743674536,0.198869052076865,-1.32440295768354,-5.11966038826609,-1.50914333154429,"ADCY2","adenylate cyclase 2",TRUE
+"217687_at",0.931582451098271,0.698032446469894,-0.393058728004747,-5.86471345315845,-0.20584837425914,"ADCY2","adenylate cyclase 2",TRUE
+"213219_at",0.996296795497044,0.982125442794002,0.0226585774303137,-5.93943342021026,0.0155983616984798,"ADCY2","adenylate cyclase 2",TRUE
+"209320_at",0.622917527985155,0.093868159800889,1.75050164539002,-4.54816141981441,0.696204741843065,"ADCY3","adenylate cyclase 3",TRUE
+"209321_s_at",0.7468442753788,0.238826139984093,1.21054329763331,-5.25007690018648,0.785270187558234,"ADCY3","adenylate cyclase 3",TRUE
+"230800_at",0.801086839730802,0.337325058805378,-0.980707300425209,-5.48178499920615,-0.390497074791463,"ADCY4","adenylate cyclase 4",TRUE
+"242891_at",0.942684843065067,0.743304957830836,0.331603306020675,-5.88626711109316,0.216172321331641,"ADCY5","adenylate cyclase 5",TRUE
+"228182_at",0.988164716416515,0.943506394410547,0.0716714569312992,-5.93718184564046,0.0520759025731978,"ADCY5","adenylate cyclase 5",TRUE
+"209195_s_at",0.327689791987697,0.00758765938100456,-2.93722337915409,-2.43440357146016,-1.3170336865622,"ADCY6","adenylate cyclase 6",TRUE
+"203741_s_at",0.461664352833154,0.0231950978917727,2.43890858765182,-3.39555381993213,2.8424729837896,"ADCY7","adenylate cyclase 7",TRUE
+"1554827_a_at",0.48580305784244,0.0284500378152328,2.34394639534024,-3.56834706968066,1.4226704643308,"ADCY7","adenylate cyclase 7",TRUE
+"206811_at",0.782471668844017,0.304667210023088,1.05082158625871,-5.4157076343397,0.665672612274111,"ADCY8","adenylate cyclase 8",TRUE
+"204498_s_at",0.129069197570352,0.000776657814369381,-3.89187326898905,-0.433647993192788,-1.98923361702163,"ADCY9","adenylate cyclase 9",TRUE
+"204497_at",0.684822907200459,0.1533226741114,-1.47860495987303,-4.92748361212646,-0.879898020673817,"ADCY9","adenylate cyclase 9",TRUE
+"215400_x_at",0.928114879020015,0.684084202797919,-0.412296248432237,-5.85722594665935,-0.28986100030261,"ADCY9","adenylate cyclase 9",TRUE
+"230237_at",0.387357699611418,0.0128168412523097,2.70732117346703,-2.8881014408936,1.7829754505936,"ADCYAP1","adenylate cyclase activating polypeptide 1",TRUE
+"206281_at",0.989586772349659,0.949579198796078,-0.0639554524621361,-5.93769144283405,-0.038596718488555,"ADCYAP1","adenylate cyclase activating polypeptide 1",TRUE
+"226690_at",0.660054711393139,0.12788563724108,1.58171480017853,-4.78948513924493,0.451754613278527,"ADCYAP1R1","ADCYAP receptor type I",TRUE
+"207151_at",0.822010986888098,0.385673773075894,0.884974584564639,-5.56525912570753,0.623089239928419,"ADCYAP1R1","ADCYAP receptor type I",TRUE
+"238939_at",0.503099817975078,0.0325830170178281,-2.28001608351689,-3.68247052840758,-1.09820862019851,"ADD1","adducin 1",TRUE
+"214736_s_at",0.630603891142543,0.101810853294433,-1.70694146782249,-4.61221030778659,-0.491154574875486,"ADD1","adducin 1",TRUE
+"208030_s_at",0.65349309458318,0.122849081062289,-1.60411631791665,-4.75853732558216,-0.536057031326051,"ADD1","adducin 1",TRUE
+"214726_x_at",0.728385463227073,0.208968386339581,-1.29406857079844,-5.15538157905812,-0.346713574595503,"ADD1","adducin 1",TRUE
+"205268_s_at",0.194325783329824,0.0020630857092406,3.48880321035673,-1.29454614099068,3.08001806031467,"ADD2","adducin 2",TRUE
+"213484_at",0.358391501004667,0.00971442532215669,2.82959315746597,-2.64875031322088,1.82900802790581,"ADD2","adducin 2",TRUE
+"230988_at",0.419667703001518,0.0173506215386531,2.5715370664789,-3.14812287649222,1.56934158091512,"ADD2","adducin 2",TRUE
+"237336_at",0.699684100574767,0.171174659886385,1.41429397775695,-5.00974987363371,1.03775998081629,"ADD2","adducin 2",TRUE
+"239530_at",0.713100716291082,0.187669066423637,1.35948520864015,-5.07748066407227,1.00157751189938,"ADD2","adducin 2",TRUE
+"206807_s_at",0.929088231432081,0.687732876372549,-0.40724896328677,-5.85922448957331,-0.142159040029076,"ADD2","adducin 2",TRUE
+"201752_s_at",0.750807729565285,0.243768202116163,1.19749519244752,-5.26437720534671,1.12050571368825,"ADD3","adducin 3",TRUE
+"201034_at",0.767965891104819,0.27074712290068,1.12954920236731,-5.3366503979224,1.23245965774882,"ADD3","adducin 3",TRUE
+"201753_s_at",0.769774279128662,0.277229957917658,1.11397212298189,-5.35269533629036,1.18470565637688,"ADD3","adducin 3",TRUE
+"205882_x_at",0.821424121108148,0.383541852536538,0.889022088407268,-5.56188994022345,0.856171160378409,"ADD3","adducin 3",TRUE
+"217380_s_at",0.933463268763089,0.705658963411358,0.382604137074243,-5.86863471824803,0.391242744100618,"ADD3-AS1","ADD3 antisense RNA 1",TRUE
+"222072_at",0.952914447461733,0.784323501566689,-0.277032216364101,-5.90237189813628,-0.212873521329778,"ADD3-AS1","ADD3 antisense RNA 1",TRUE
+"228215_at",0.976371465776674,0.886806440863937,-0.143994554059351,-5.9295895467899,-0.0788606884144905,"ADD3-AS1","ADD3 antisense RNA 1",TRUE
+"220614_s_at",0.650490742096872,0.120543198249324,1.61462894533746,-4.74389757164031,1.43523972704306,"ADGB","androglobin",TRUE
+"239221_at",0.746259710622309,0.237922889064439,-1.21295000941151,-5.24742453671376,-0.974394444226064,"ADGRA1","adhesion G protein-coupled receptor A1",TRUE
+"221814_at",0.661121988136487,0.128838525269687,-1.57755939693469,-4.79518848142621,-1.00849360222808,"ADGRA2","adhesion G protein-coupled receptor A2",TRUE
+"65718_at",0.934781502857546,0.710355333119644,-0.376187862561218,-5.87098969607232,-0.210309905241443,"ADGRA2","adhesion G protein-coupled receptor A2",TRUE
+"210473_s_at",0.358427723880268,0.0100892717265473,2.81299117323659,-2.68151853876904,1.1752291910621,"ADGRA3","adhesion G protein-coupled receptor A3",TRUE
+"1555122_at",0.397229407433966,0.0137699986567062,2.67537860200076,-2.94984186818073,0.866737666427355,"ADGRA3","adhesion G protein-coupled receptor A3",TRUE
+"1569542_at",0.575270671804438,0.0608851930461151,1.97477085947584,-4.20018332514307,1.3272920571449,"ADGRA3","adhesion G protein-coupled receptor A3",TRUE
+"206083_at",0.68041487556515,0.148119185702165,1.49848991919235,-4.90144811102531,0.73113998459971,"ADGRB1","adhesion G protein-coupled receptor B1",TRUE
+"204966_at",0.941952420964607,0.739285175901471,-0.337004144328664,-5.88451773327392,-0.257104798586772,"ADGRB2","adhesion G protein-coupled receptor B2",TRUE
+"205638_at",0.921919360038633,0.666940119293472,0.436161174639815,-5.84744863291018,0.246878840439299,"ADGRB3","adhesion G protein-coupled receptor B3",TRUE
+"211568_at",0.947969282616012,0.763200791863562,0.305015983567996,-5.89447099724677,0.312889978246509,"ADGRB3","adhesion G protein-coupled receptor B3",TRUE
+"232267_at",0.774230543658252,0.28732051201188,1.09024525768045,-5.37675471709156,1.30216072266293,"ADGRD1","adhesion G protein-coupled receptor D1",TRUE
+"216289_at",0.986889306520757,0.939334834081636,0.0769743277311933,-5.93679802074818,0.0531348533681637,"ADGRD2","adhesion G protein-coupled receptor D2",TRUE
+"207111_at",0.756601922352523,0.252019830989476,1.17614461296447,-5.28748557498358,0.793202457680589,"ADGRE1","adhesion G protein-coupled receptor E1",TRUE
+"207610_s_at",0.172191176660265,0.0015053933688817,3.61949989752491,-1.01711874792555,2.96935754529279,"ADGRE2","adhesion G protein-coupled receptor E2",TRUE
+"232009_at",0.402463840838386,0.0147971916891722,2.64320972214375,-3.01167146329392,1.56364750430901,"ADGRE2","adhesion G protein-coupled receptor E2",TRUE
+"210724_at",0.676444026841093,0.143182198859295,1.51789083473029,-4.87577777604582,1.05932139529403,"ADGRE3","adhesion G protein-coupled receptor E3",TRUE
+"202910_s_at",0.548924465506383,0.048538556477722,2.08764049598945,-4.0142828580948,2.29534016612819,"ADGRE5","adhesion G protein-coupled receptor E5",TRUE
+"235988_at",0.30050033261608,0.005692844917486,3.06095754194556,-2.18421155410425,3.11593965686114,"ADGRF1","adhesion G protein-coupled receptor F1",TRUE
+"236489_at",0.348854934125219,0.00916175878914739,2.855218272492,-2.59801394382071,3.8348553744178,"ADGRF1","adhesion G protein-coupled receptor F1",TRUE
+"238689_at",0.361092857488395,0.0103910541386885,2.80004599922852,-2.707012050568,4.7742331639936,"ADGRF1","adhesion G protein-coupled receptor F1",TRUE
+"220907_at",0.525405708458677,0.0393700338157774,2.18958230571121,-3.84069606776187,1.9182592281218,"ADGRF1","adhesion G protein-coupled receptor F1",TRUE
+"1553036_at",0.936143408699214,0.715241030880193,0.36952994579404,-5.87339182506481,0.239532379242155,"ADGRF2","adhesion G protein-coupled receptor F2",TRUE
+"236608_at",0.492341486607851,0.0295990208775493,2.32535964962046,-3.60171451285852,1.5011403587893,"ADGRF3","adhesion G protein-coupled receptor F3",TRUE
+"1553016_at",0.998047179825832,0.991339254734032,-0.0109779915585479,-5.93962478187388,-0.00536973510317917,"ADGRF3","adhesion G protein-coupled receptor F3",TRUE
+"1553031_at",0.308861881799719,0.00647200577030415,3.00588921993219,-2.2960295336394,2.09154915877445,"ADGRF4","adhesion G protein-coupled receptor F4",TRUE
+"237690_at",0.369429132228615,0.0110195823163535,2.77419367695645,-2.75777195654058,2.56026668311208,"ADGRF4","adhesion G protein-coupled receptor F4",TRUE
+"212951_at",0.88734438113787,0.551817033435185,-0.604247089590006,-5.76339737144901,-0.703761005705697,"ADGRF5","adhesion G protein-coupled receptor F5",TRUE
+"212950_at",0.9273609306408,0.681981313199914,-0.415210166638759,-5.85606111436118,-0.356467462729261,"ADGRF5","adhesion G protein-coupled receptor F5",TRUE
+"206582_s_at",0.942684843065067,0.743482772847199,0.331364633348481,-5.88634377407646,0.367383596873612,"ADGRG1","adhesion G protein-coupled receptor G1",TRUE
+"212070_at",0.974650227305537,0.875900617675982,0.157983719123935,-5.9275342490674,0.182398414815168,"ADGRG1","adhesion G protein-coupled receptor G1",TRUE
+"206002_at",0.979481436032858,0.901183716155213,-0.125596864485874,-5.93200318760864,-0.156218658969466,"ADGRG2","adhesion G protein-coupled receptor G2",TRUE
+"1553723_at",0.73957587762701,0.22822207372554,1.23924404291797,-5.21815019821786,0.795541356873743,"ADGRG3","adhesion G protein-coupled receptor G3",TRUE
+"220404_at",0.841618504666446,0.433451212354962,-0.79780528570969,-5.63433688308455,-0.371013624651049,"ADGRG3","adhesion G protein-coupled receptor G3",TRUE
+"1553006_at",0.931501755169233,0.697071669974055,-0.394378924581138,-5.86421087247161,-0.286287243690583,"ADGRG4","adhesion G protein-coupled receptor G4",TRUE
+"229971_at",0.55937703282623,0.0532136082227445,2.04217766102023,-4.08998145639529,1.19428326329561,"ADGRG5","adhesion G protein-coupled receptor G5",TRUE
+"1555447_at",0.914966942918905,0.641916221166933,0.4714676900793,-5.83199431876993,0.187123843425296,"ADGRG5","adhesion G protein-coupled receptor G5",TRUE
+"233887_at",0.425751189365875,0.0182336441146983,2.54904145873819,-3.19056561036,1.50502881183679,"ADGRG6","adhesion G protein-coupled receptor G6",TRUE
+"213094_at",0.612111927345277,0.08373935993638,1.81089052836533,-4.45740913971122,1.17628836430672,"ADGRG6","adhesion G protein-coupled receptor G6",TRUE
+"1553025_at",0.989108041907445,0.947029115424103,0.0671950338365617,-5.93748454592849,0.0271744023801528,"ADGRG6","adhesion G protein-coupled receptor G6",TRUE
+"1553296_at",0.96524710859925,0.838083415444418,0.206762817163041,-5.91888253693309,0.140410779164434,"ADGRG7","adhesion G protein-coupled receptor G7",TRUE
+"203488_at",0.691063803085828,0.160748961090911,-1.45115432866429,-4.96296259248498,-0.628934777477125,"ADGRL1","adhesion G protein-coupled receptor L1",TRUE
+"47560_at",0.710824498521146,0.18420982751799,-1.37065357526492,-5.06385947941561,-0.655152097856369,"ADGRL1","adhesion G protein-coupled receptor L1",TRUE
+"219145_at",0.740476003158683,0.229738840158471,-1.23507761848241,-5.22282498346303,-0.526113575457243,"ADGRL1","adhesion G protein-coupled receptor L1",TRUE
+"1569850_at",0.912722788750542,0.633922537555666,-0.4828732779212,-5.82675032060642,-0.312258351739189,"ADGRL2","adhesion G protein-coupled receptor L2",TRUE
+"206953_s_at",0.98539961718117,0.928589908121326,0.0906440366151109,-5.93568239601352,0.138401133265042,"ADGRL2","adhesion G protein-coupled receptor L2",TRUE
+"242186_x_at",0.536422380101288,0.0431701540511144,2.14497066567962,-3.91730168975708,2.03052115707543,"ADGRL3","adhesion G protein-coupled receptor L3",TRUE
+"236264_at",0.872668627020452,0.516746860768082,-0.658904456577889,-5.73040644496183,-0.354614079877978,"ADGRL3","adhesion G protein-coupled receptor L3",TRUE
+"209866_s_at",0.946160605976344,0.756080531060127,-0.314504205600693,-5.89162115605512,-0.257003477345576,"ADGRL3","adhesion G protein-coupled receptor L3",TRUE
+"209867_s_at",0.956734254923335,0.803815063649047,0.251408894347182,-5.90894476262589,0.214408122450289,"ADGRL3","adhesion G protein-coupled receptor L3",TRUE
+"219134_at",0.977470553955881,0.891925120015709,0.137439005403367,-5.93048729726365,0.108861142442787,"ADGRL4","adhesion G protein-coupled receptor L4",TRUE
+"223582_at",0.48580305784244,0.0282654246256512,-2.34699700428745,-3.56285605094418,-2.55116429481756,"ADGRV1","adhesion G protein-coupled receptor V1",TRUE
+"224275_at",0.785175995766517,0.310588030262955,1.03773182518634,-5.42835634459132,1.09778144820204,"ADGRV1","adhesion G protein-coupled receptor V1",TRUE
+"240631_at",0.839519981963042,0.428084235303671,0.807284592698952,-5.62714968903131,0.433810233445716,"ADGRV1","adhesion G protein-coupled receptor V1",TRUE
+"234871_at",0.907871409554181,0.617482336370815,0.506538497110596,-5.81547903372716,0.427411433641518,"ADGRV1","adhesion G protein-coupled receptor V1",TRUE
+"215396_at",0.977874971442423,0.892810959925632,-0.136305134500555,-5.9306383406437,-0.148670357210893,"ADGRV1","adhesion G protein-coupled receptor V1",TRUE
+"207820_at",0.998384473324293,0.993367826531517,-0.00840658742067168,-5.93964905970947,-0.00305212373028318,"ADH1A","alcohol dehydrogenase 1A (class I), alpha polypeptide",TRUE
+"209612_s_at",0.681321116294195,0.149186135067401,1.49436672903336,-4.90686960948776,0.976030173058737,"ADH1B","alcohol dehydrogenase 1B (class I), beta polypeptide",TRUE
+"209614_at",0.70573152022539,0.177959357800058,1.39126185462177,-5.03848217942671,0.827797724317961,"ADH1B","alcohol dehydrogenase 1B (class I), beta polypeptide",TRUE
+"243544_at",0.748438284778152,0.241292613257556,1.20400614345418,-5.25725823275545,0.882474371312767,"ADH1B","alcohol dehydrogenase 1B (class I), beta polypeptide",TRUE
+"209613_s_at",0.827793155763086,0.39677345795268,0.864133445683901,-5.58238154677621,0.799415134304196,"ADH1B","alcohol dehydrogenase 1B (class I), beta polypeptide",TRUE
+"206262_at",0.73612054366523,0.221448755412999,1.25811162489076,-5.1968111721772,1.10757430814638,"ADH1C","alcohol dehydrogenase 1C (class I), gamma polypeptide",TRUE
+"231703_s_at",0.740476003158683,0.229744371979632,1.23506246139591,-5.2228419651573,1.04677649700109,"ADH4","alcohol dehydrogenase 4 (class II), pi polypeptide",TRUE
+"231675_s_at",0.816800680706682,0.368205816057578,0.918583291664484,-5.53685207942975,0.71941500783167,"ADH4","alcohol dehydrogenase 4 (class II), pi polypeptide",TRUE
+"231678_s_at",0.896428361916712,0.580932851820726,0.560245840802431,-5.78795189426507,0.462699949915498,"ADH4","alcohol dehydrogenase 4 (class II), pi polypeptide",TRUE
+"223781_x_at",0.932415412515157,0.701983974037002,0.387636398297582,-5.86676024291862,0.234680173260803,"ADH4","alcohol dehydrogenase 4 (class II), pi polypeptide",TRUE
+"208848_at",0.90360437116293,0.604894759379902,-0.524857472489817,-5.80639299835205,-0.184510312739089,"ADH5","alcohol dehydrogenase 5 (class III), chi polypeptide",TRUE
+"208847_s_at",0.967701855457407,0.848181815697078,0.193691946747115,-5.9214270450628,0.0671520658543976,"ADH5","alcohol dehydrogenase 5 (class III), chi polypeptide",TRUE
+"207544_s_at",0.927151504869754,0.681627659441091,0.415700573905075,-5.8558642819293,0.313992771320267,"ADH6","alcohol dehydrogenase 6 (class V)",TRUE
+"214261_s_at",0.957208446914964,0.806307210118453,-0.248145486727074,-5.90973641599543,-0.147502229021371,"ADH6","alcohol dehydrogenase 6 (class V)",TRUE
+"210505_at",0.532087626503272,0.0418371231154561,2.16020020720585,-3.89126042126496,0.722256828705275,"ADH7","alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide",TRUE
+"227113_at",0.742608345161152,0.232887465951047,1.22649490778614,-5.23241210519213,0.488804092525214,"ADHFE1","alcohol dehydrogenase, iron containing 1",TRUE
+"241443_at",0.731054546207485,0.214102867919372,1.27908061257539,-5.17277170867025,0.67005898880485,"ADI1","acireductone dioxygenase 1",TRUE
+"217761_at",0.867569240837399,0.500167353277287,0.685453302288514,-5.7133937203392,0.408126838971079,"ADI1","acireductone dioxygenase 1",TRUE
+"222400_s_at",0.882464151621958,0.540105260562855,0.622286506936462,-5.75281275683247,0.256188786225868,"ADI1","acireductone dioxygenase 1",TRUE
+"1554129_a_at",0.761311110432845,0.260424946860106,1.15492590676191,-5.31009082244939,0.543158542342688,"ADIG","adipogenin",TRUE
+"1554128_at",0.954723352940649,0.794039023683232,-0.264237741412489,-5.90573306444648,-0.216547329271856,"ADIG","adipogenin",TRUE
+"207175_at",0.757361197594703,0.253350984746071,1.17274942205873,-5.29112683729268,0.72682714800967,"ADIPOQ","adiponectin, C1Q and collagen domain containing",TRUE
+"217748_at",0.686572269189448,0.155057967625996,-1.47209565817917,-4.93594533655665,-0.506021128816498,"ADIPOR1","adiponectin receptor 1",TRUE
+"201346_at",0.873803688685077,0.519599552382793,-0.654384551484846,-5.73323868836649,-0.230965944000866,"ADIPOR2","adiponectin receptor 2",TRUE
+"203571_s_at",0.812302873476553,0.360448475126318,0.933848051633332,-5.5236276324196,1.93913911894299,"ADIRF","adipogenesis regulatory factor",TRUE
+"232300_at",0.955904644595647,0.800432193093379,0.255843160516816,-5.90785260317743,0.11782583292038,"ADIRF-AS1","ADIRF antisense RNA 1",TRUE
+"204119_s_at",0.795924451457704,0.328155753834962,0.999897385182531,-5.46411059283512,0.376908303787523,"ADK","adenosine kinase",TRUE
+"204120_s_at",0.905462783815257,0.611279690895176,0.515543009843143,-5.81105219352749,0.216733447163058,"ADK","adenosine kinase",TRUE
+"202912_at",0.945820394457833,0.75534012530422,0.315492523573388,-5.89131933635503,0.375862276830416,"ADM","adrenomedullin",TRUE
+"220538_at",0.917887697142565,0.651256208365757,-0.458220962114093,-5.83793078490378,-0.296666322693361,"ADM2","adrenomedullin 2",TRUE
+"232154_at",0.986285942607238,0.932916640335077,-0.085137583894563,-5.93615366493678,-0.0495425272071586,"ADM5","adrenomedullin 5 (putative)",TRUE
+"201773_at",0.714795139167042,0.190359878800332,-1.35090953032739,-5.08787658850484,-0.416660766589104,"ADNP","activity dependent neuroprotector homeobox",TRUE
+"226426_at",0.948429371744093,0.765105749610461,-0.302482375143265,-5.89521734680549,-0.133275174567443,"ADNP","activity dependent neuroprotector homeobox",TRUE
+"203321_s_at",0.854040699678541,0.462922904981927,-0.746991009504132,-5.67149866393884,-0.267003256377492,"ADNP2","ADNP homeobox 2",TRUE
+"203322_at",0.896907177224677,0.582004049962142,-0.558648631921305,-5.78880938156533,-0.229617779192019,"ADNP2","ADNP homeobox 2",TRUE
+"212500_at",0.575270671804438,0.060906627174952,-1.97459334873325,-4.20047025232724,-0.672627690791103,"ADO","2-aminoethanethiol dioxygenase",TRUE
+"212502_at",0.767945391174396,0.270532219390738,-1.13007022493412,-5.33611032211778,-0.341942834207156,"ADO","2-aminoethanethiol dioxygenase",TRUE
+"216220_s_at",0.598372511979028,0.0754819426633628,-1.8649934632671,-4.37422210683155,-0.818631321525146,"ADORA1","adenosine A1 receptor",TRUE
+"205481_at",0.612420348961838,0.0841377302939426,-1.80839933049685,-4.46119714624667,-1.51472253994721,"ADORA1","adenosine A1 receptor",TRUE
+"237447_at",0.794620886196317,0.326575152358158,-1.00324271237134,-5.46099765182435,-0.707152762121986,"ADORA2A-AS1","ADORA2A antisense RNA 1",TRUE
+"239513_at",0.909934011695618,0.625010132114362,0.49566686178881,-5.82072237103966,0.250582666484715,"ADORA2A-AS1","ADORA2A antisense RNA 1",TRUE
+"205891_at",0.541726750714865,0.0452107757386727,2.12245987461892,-3.95558068880653,2.28304359434098,"ADORA2B","adenosine A2b receptor",TRUE
+"223660_at",0.802375933455311,0.340158724708491,-0.974849562247749,-5.48711795211268,-0.744291169428218,"ADORA3","adenosine A3 receptor",TRUE
+"206171_at",0.916057757219214,0.645875741941461,0.465841656708435,-5.83453584186419,0.216375268627551,"ADORA3","adenosine A3 receptor",TRUE
+"224455_s_at",0.929972194057784,0.690852218465247,0.402942435523527,-5.86091056443266,0.16617605958424,"ADPGK","ADP dependent glucokinase",TRUE
+"220980_s_at",0.995678148676256,0.979350593198273,0.0261768825705735,-5.93934973639032,0.00940305710902578,"ADPGK","ADP dependent glucokinase",TRUE
+"238505_at",0.345235484905341,0.00875941771204527,2.87481734812156,-2.55908132003892,0.744620508586335,"ADPRH","ADP-ribosylarginine hydrolase",TRUE
+"228042_at",0.562643595171948,0.0552332800652373,2.02363324940254,-4.12054474741779,2.21783275800299,"ADPRH","ADP-ribosylarginine hydrolase",TRUE
+"207863_at",0.787983178144695,0.314047678611519,1.03016459151612,-5.43560345821371,0.603473304515806,"ADPRH","ADP-ribosylarginine hydrolase",TRUE
+"238054_at",0.805081687922468,0.344252488009865,-0.966445672000957,-5.49471804195147,-0.477556063293463,"ADPRHL1","ADP-ribosylhydrolase like 1",TRUE
+"1553163_at",0.845487921422997,0.442533153651774,-0.781928151180589,-5.64619593885658,-0.321767024687731,"ADPRHL1","ADP-ribosylhydrolase like 1",TRUE
+"223097_at",0.903678874758741,0.605185370874463,-0.524432506318243,-5.80660734010581,-0.136877342936753,"ADPRHL2","ADP-ribosylhydrolase like 2",TRUE
+"220606_s_at",0.501591596209182,0.0322267657478595,2.28522460771399,-3.67324147200402,0.800274116363906,"ADPRM","ADP-ribose/CDP-alcohol diphosphatase, manganese dependent",TRUE
+"223401_at",0.547343369043481,0.047895764231814,2.09419543327587,-4.00327943512451,0.665909264903249,"ADPRM","ADP-ribose/CDP-alcohol diphosphatase, manganese dependent",TRUE
+"237390_at",0.402463840838386,0.0148294722332118,2.64223324831278,-3.01354270985826,1.88532681836505,"ADRA1A","adrenoceptor alpha 1A",TRUE
+"211489_at",0.614024511254138,0.0849333522456649,-1.80345430457703,-4.46870516117933,-1.11504849621683,"ADRA1A","adrenoceptor alpha 1A",TRUE
+"211491_at",0.812302873476553,0.357900807463425,0.938909255208649,-5.51919869522336,0.672559481408258,"ADRA1A","adrenoceptor alpha 1A",TRUE
+"211490_at",0.934031069172341,0.707745279647754,-0.379751767041043,-5.86968647848732,-0.270178021239999,"ADRA1A","adrenoceptor alpha 1A",TRUE
+"211492_s_at",0.999474141961793,0.998285923960375,0.00217264590700869,-5.93968118162132,0.00148116047596281,"ADRA1A","adrenoceptor alpha 1A",TRUE
+"207589_at",0.308621629697291,0.00633557304593849,3.0150546270501,-2.27746966265029,2.31106181975402,"ADRA1B","adrenoceptor alpha 1B",TRUE
+"210960_at",0.5300389800612,0.0414627657562277,2.16455601747208,-3.88379118341805,1.00051097270169,"ADRA1D","adrenoceptor alpha 1D",TRUE
+"210961_s_at",0.926430328514448,0.680337372697112,0.417490679073018,-5.85514385671052,0.285131919242943,"ADRA1D","adrenoceptor alpha 1D",TRUE
+"209869_at",0.917102138198416,0.649022322367166,-0.461381586188285,-5.83652941613042,-0.705441917417683,"ADRA2A","adrenoceptor alpha 2A",TRUE
+"208544_at",0.828070400350931,0.397845566666766,0.862140505633098,-5.58399901419804,0.457061515370539,"ADRA2B","adrenoceptor alpha 2B",TRUE
+"206128_at",0.0952827619788257,0.000405435358389354,-4.15769389139715,0.139774879901139,-2.68241668057017,"ADRA2C","adrenoceptor alpha 2C",TRUE
+"229309_at",0.762857166457304,0.262627100491144,-1.14945061971823,-5.31586526319312,-1.55825262247146,"ADRB1","adrenoceptor beta 1",TRUE
+"229277_at",0.766550448794594,0.267822567602995,-1.13666582014242,-5.32925452863611,-0.787720851675902,"ADRB1","adrenoceptor beta 1",TRUE
+"208214_at",0.843095426822889,0.437385888993576,-0.790901774299249,-5.63952087262783,-0.47874714406869,"ADRB1","adrenoceptor beta 1",TRUE
+"206170_at",0.325914865754316,0.0074779540245351,2.94353044555477,-2.42174450729092,2.29097521938816,"ADRB2","adrenoceptor beta 2",TRUE
+"206812_at",0.772719741774806,0.283274931305359,-1.09968436144484,-5.36723847782538,-0.732448755938806,"ADRB3","adrenoceptor beta 3",TRUE
+"217303_s_at",0.9181984176728,0.652893745223918,0.455907093794372,-5.83895073094815,0.190590323551928,"ADRB3","adrenoceptor beta 3",TRUE
+"201281_at",0.999140297569648,0.99727633213111,0.00345233999564113,-5.93967767561509,0.00136707452329077,"ADRM1","adhesion regulating molecule 1",TRUE
+"202144_s_at",0.862800800218883,0.486797928042954,0.707227042508156,-5.69896192526183,0.269486663973664,"ADSL","adenylosuccinate lyase",TRUE
+"210250_x_at",0.953774206775359,0.786709460167768,0.273885827257812,-5.9032130973636,0.10627715358485,"ADSL","adenylosuccinate lyase",TRUE
+"221761_at",0.910210488418964,0.626917358443189,-0.492922086418235,-5.82202860119744,-0.169186203048969,"ADSS","adenylosuccinate synthase",TRUE
+"227310_at",0.987529263461283,0.941309100951956,0.0744643752185343,-5.93698310420753,0.0426066355278962,"ADSS","adenylosuccinate synthase",TRUE
+"238259_at",0.820291269575398,0.378880234502349,0.897923911818592,-5.55442989464976,0.259464026713658,"ADSSL1","adenylosuccinate synthase like 1",TRUE
+"226325_at",0.858727210107016,0.474577940192787,-0.727432833825992,-5.68518498474828,-0.820361541777701,"ADSSL1","adenylosuccinate synthase like 1",TRUE
+"229070_at",0.165626734753013,0.00134358838955523,3.66647753875217,-0.916935300927654,3.31650110786943,"ADTRP","androgen dependent TFPI regulating protein",TRUE
+"215100_at",0.203739112628724,0.00229171567017221,3.44503341492345,-1.38697198252001,0.885466252181327,"ADTRP","androgen dependent TFPI regulating protein",TRUE
+"201792_at",0.26392932766945,0.0040033244995144,3.21081327875531,-1.87647222425678,1.99628993579058,"AEBP1","AE binding protein 1",TRUE
+"235184_at",0.694024616341183,0.163405192248012,1.44158462979906,-4.97520403287383,0.62894777630413,"AEBP2","AE binding protein 2",TRUE
+"225889_at",0.763044089435492,0.262846105304636,1.14890795670294,-5.31643626173832,0.467572442153905,"AEBP2","AE binding protein 2",TRUE
+"219361_s_at",0.710672261019989,0.183699365722019,-1.37231564082056,-5.06182445526917,-0.549565669737605,"AEN","apoptosis enhancing nuclease",TRUE
+"217729_s_at",0.943512938262733,0.747309529228391,-0.326232887935982,-5.88797890514357,-0.139401477360341,"AES","amino-terminal enhancer of split",TRUE
+"203563_at",0.958813918694598,0.81368922018803,0.238494910661626,-5.91201732737962,0.242157372422145,"AFAP1","actin filament associated protein 1",TRUE
+"1558216_at",0.0550194051692779,0.000100629913432607,4.72652186163379,1.36646792202305,2.8845100603743,"AFAP1-AS1","AFAP1 antisense RNA 1",TRUE
+"223779_at",0.240221409886232,0.0031934094596378,3.30614321191291,-1.67836605992397,1.84354973133855,"AFAP1-AS1","AFAP1 antisense RNA 1",TRUE
+"226955_at",0.380084968057051,0.0118378209618914,2.74255824681013,-2.81960474235828,3.64539756308755,"AFAP1L1","actin filament associated protein 1 like 1",TRUE
+"1555542_at",0.834887691123811,0.413664518565049,0.833126382894649,-5.60715234801931,0.57908869098901,"AFAP1L1","actin filament associated protein 1 like 1",TRUE
+"226829_at",0.332429060350567,0.00814732402139478,2.90634680519457,-2.49622330795181,3.13698198214399,"AFAP1L2","actin filament associated protein 1 like 2",TRUE
+"214939_x_at",0.712297714477645,0.186363398364933,1.36368138178376,-5.07237381467521,0.991494597904046,"AFDN","afadin, adherens junction formation factor",TRUE
+"224685_at",0.736223289546449,0.221678564212765,1.2574642964803,-5.19754787686127,0.636049632713133,"AFDN","afadin, adherens junction formation factor",TRUE
+"229775_s_at",0.737123149977386,0.222910960142555,1.25400160435068,-5.20148314021583,0.582859690673668,"AFDN","afadin, adherens junction formation factor",TRUE
+"208512_s_at",0.7994347047598,0.334678689289574,0.986208463976357,-5.47675018274857,0.935708287133547,"AFDN","afadin, adherens junction formation factor",TRUE
+"230622_at",0.897024165042344,0.58299595927976,-0.55717095523998,-5.78960058059149,-0.328858088560423,"AFDN","afadin, adherens junction formation factor",TRUE
+"238871_at",0.91238586368984,0.63295297452904,0.48426107292401,-5.82610388290364,0.198003204671119,"AFDN","afadin, adherens junction formation factor",TRUE
+"215904_at",0.974536463688956,0.875671792773401,0.158277574400982,-5.92748903832446,0.143131985618033,"AFDN","afadin, adherens junction formation factor",TRUE
+"210409_at",0.69227042558579,0.161637679966037,-1.44793840390606,-4.96708372352739,-0.725168427047706,"AFDN-AS1","AFDN antisense RNA 1 (head to head)",TRUE
+"201924_at",0.796178939717214,0.328446565803782,-0.999283102549664,-5.46468117845018,-0.374897080900103,"AFF1","AF4/FMR2 family member 1",TRUE
+"215451_s_at",0.884280800556985,0.543296948373301,-0.617350002958208,-5.75573907834854,-0.347409478073348,"AFF1","AF4/FMR2 family member 1",TRUE
+"211826_s_at",0.970540753946729,0.859760836901886,-0.178746865642682,-5.9241335694209,-0.0579590780363777,"AFF1","AF4/FMR2 family member 1",TRUE
+"206105_at",0.345766760173066,0.0087928194138947,2.87315792244512,-2.56238191254072,0.934803881676976,"AFF2","AF4/FMR2 family member 2",TRUE
+"216364_s_at",0.700061364939874,0.171494384214866,-1.41319238260649,-5.0111329491789,-0.923413366631304,"AFF2","AF4/FMR2 family member 2",TRUE
+"210957_s_at",0.817055852876968,0.369343563501686,0.91636254159239,-5.53875927457742,0.471089030609858,"AFF2","AF4/FMR2 family member 2",TRUE
+"227198_at",0.711036775119501,0.184806304590618,-1.36871605391822,-5.06622917897838,-2.96868776031425,"AFF3","AF4/FMR2 family member 3",TRUE
+"243967_at",0.801587742916188,0.33867070479602,-0.977921396846535,-5.48432494936749,-1.28669069484366,"AFF3","AF4/FMR2 family member 3",TRUE
+"205735_s_at",0.864079461576774,0.490988764965319,-0.700365285526117,-5.70355640294313,-0.709132706826193,"AFF3","AF4/FMR2 family member 3",TRUE
+"1565034_s_at",0.912141993216912,0.631699981561669,-0.486055988882163,-5.82526511775137,-0.400166192903152,"AFF3","AF4/FMR2 family member 3",TRUE
+"205734_s_at",0.930899509890345,0.694454673583029,-0.397978550940333,-5.86283211101244,-0.309115155236614,"AFF3","AF4/FMR2 family member 3",TRUE
+"242078_at",0.959357995170594,0.81581449896169,-0.235720840608607,-5.91265633079935,-0.180927472663599,"AFF3","AF4/FMR2 family member 3",TRUE
+"225229_at",0.497725944448536,0.0307696450631017,-2.30709236038374,-3.63435937507643,-0.684626660599807,"AFF4","AF4/FMR2 family member 4",TRUE
+"232865_at",0.748237011093779,0.240786021331586,-1.20534469715476,-5.25579052406351,-0.482319176376197,"AFF4","AF4/FMR2 family member 4",TRUE
+"1555435_at",0.780753957748649,0.302478072281333,1.05570697840731,-5.41095034730489,0.964182062222085,"AFF4","AF4/FMR2 family member 4",TRUE
+"219199_at",0.803135302652907,0.341090615420602,-0.972930473733705,-5.48885877706085,-0.293913380380079,"AFF4","AF4/FMR2 family member 4",TRUE
+"239439_at",0.835838027302116,0.4153953977998,-0.829994835353434,-5.60960706563526,-0.337444338906861,"AFF4","AF4/FMR2 family member 4",TRUE
+"243487_at",0.896115372949367,0.577336132474386,-0.565619549897278,-5.78504949917397,-0.211629126576394,"AFF4","AF4/FMR2 family member 4",TRUE
+"1555436_a_at",0.9340157600858,0.707708837340603,0.379801562648713,-5.86966818381435,0.12399307904931,"AFF4","AF4/FMR2 family member 4",TRUE
+"232864_s_at",0.961146128665821,0.822674284943815,-0.22677971319858,-5.91466529057933,-0.0863924033556502,"AFF4","AF4/FMR2 family member 4",TRUE
+"1552287_s_at",0.728343447580122,0.208634141822104,-1.29505408866752,-5.15423207537382,-0.421929275626084,"AFG3L1P","AFG3 like matrix AAA peptidase subunit 1, pseudogene",TRUE
+"236250_at",0.939166148226364,0.727581296124943,0.352788119840866,-5.87924501039415,0.0966426821139983,"AFG3L1P","AFG3 like matrix AAA peptidase subunit 1, pseudogene",TRUE
+"1559863_a_at",0.981836322577249,0.913076354051446,0.110412372390314,-5.93374749057353,0.0368429609630851,"AFG3L1P","AFG3 like matrix AAA peptidase subunit 1, pseudogene",TRUE
+"232919_at",0.604395008363632,0.0786208145986858,1.84384823507837,-4.40694255336773,1.20775986711937,"AFG3L2","AFG3 like matrix AAA peptidase subunit 2",TRUE
+"1557820_at",0.681732274610686,0.149402815244373,1.49353231610824,-4.90796530239425,0.516299167950642,"AFG3L2","AFG3 like matrix AAA peptidase subunit 2",TRUE
+"202486_at",0.814362444834356,0.365248779116499,0.924376530610108,-5.53185679226613,0.321132245151709,"AFG3L2","AFG3 like matrix AAA peptidase subunit 2",TRUE
+"206840_at",0.824584253810164,0.392030052008073,-0.872992934659394,-5.57514917607585,-0.414792495445543,"AFM","afamin",TRUE
+"240318_at",0.873688059772933,0.519316855130638,0.6548318541031,-5.73295923533771,0.642939253379146,"AFMID","arylformamidase",TRUE
+"204694_at",0.986342822130003,0.935405528107263,-0.0819713123098143,-5.93641128923472,-0.0715706267536689,"AFP","alpha fetoprotein",TRUE
+"222472_at",0.975475861996229,0.883183013600279,0.148639008883324,-5.92892825049921,0.0458625432820963,"AFTPH","aftiphilin",TRUE
+"217939_s_at",0.998506019272784,0.993702963341028,0.00798177629417925,-5.93965245061216,0.0023792845055528,"AFTPH","aftiphilin",TRUE
+"204332_s_at",0.806735395676905,0.348004272052768,-0.95880348219437,-5.5015770909132,-0.530190385565703,"AGA","aspartylglucosaminidase",TRUE
+"204333_s_at",0.810358506471539,0.354265068071564,-0.946174180372926,-5.51280293539495,-0.586657725415263,"AGA","aspartylglucosaminidase",TRUE
+"216064_s_at",0.923050713409153,0.670269033813812,-0.431507506496473,-5.84939762624885,-0.248693470664971,"AGA","aspartylglucosaminidase",TRUE
+"235968_at",0.555384632952999,0.051510845426697,-2.05830682313757,-4.06324977666651,-0.592438923023395,"AGAP1","ArfGAP with GTPase domain, ankyrin repeat and PH domain 1",TRUE
+"204066_s_at",0.778295711796067,0.297875649747845,-1.06606061285566,-5.40080280532668,-0.315676146647634,"AGAP1","ArfGAP with GTPase domain, ankyrin repeat and PH domain 1",TRUE
+"228240_at",0.90115698600215,0.597669000768065,-0.535455608265888,-5.80099292513795,-0.165905113862193,"AGAP1","ArfGAP with GTPase domain, ankyrin repeat and PH domain 1",TRUE
+"1557382_x_at",0.661221664662217,0.128939513985798,1.57712049738191,-4.79579019083408,1.15974032794439,"AGAP11","ArfGAP with GTPase domain, ankyrin repeat and PH domain 11",TRUE
+"1557380_at",0.683970477958028,0.152980743448409,1.47989463607764,-4.92580352857479,0.96969691491136,"AGAP11","ArfGAP with GTPase domain, ankyrin repeat and PH domain 11",TRUE
+"206152_at",0.725276957219979,0.204089128444695,1.30857809922467,-5.13838279655008,0.669004214890399,"AGAP2","ArfGAP with GTPase domain, ankyrin repeat and PH domain 2",TRUE
+"215080_s_at",0.752155597823425,0.245304466027871,1.19347965310268,-5.26875099566843,1.0038473410843,"AGAP2","ArfGAP with GTPase domain, ankyrin repeat and PH domain 2",TRUE
+"229917_at",0.816800680706682,0.367936685317337,0.919109270760922,-5.53639974192902,0.237991535957835,"AGAP2","ArfGAP with GTPase domain, ankyrin repeat and PH domain 2",TRUE
+"1555907_at",0.978255630670068,0.894926753778005,0.1335976658054,-5.93099395147214,0.150800046040485,"AGAP2-AS1","AGAP2 antisense RNA 1",TRUE
+"225789_at",0.670152406964446,0.13579832508416,-1.54795775523756,-4.83547581987817,-0.450114013834243,"AGAP3","ArfGAP with GTPase domain, ankyrin repeat and PH domain 3",TRUE
+"231299_at",0.76524135343539,0.26538163145769,-1.14264942331946,-5.3230044389871,-0.476377484813861,"AGAP3","ArfGAP with GTPase domain, ankyrin repeat and PH domain 3",TRUE
+"239026_x_at",0.948109877411639,0.76438378411166,0.303442356079957,-5.89493528196992,0.0831028869435286,"AGAP3","ArfGAP with GTPase domain, ankyrin repeat and PH domain 3",TRUE
+"1565620_at",0.879716812354048,0.534430320989387,0.631102527845711,-5.74753086002023,0.314629044539237,"AGAP4","ArfGAP with GTPase domain, ankyrin repeat and PH domain 4",TRUE
+"243937_x_at",0.881970070870254,0.539295234957926,0.623541830825185,-5.75206502982818,0.333167256320547,"AGAP6","ArfGAP with GTPase domain, ankyrin repeat and PH domain 6",TRUE
+"242393_x_at",0.908367146600979,0.619184914250972,0.504074263846246,-5.81667725147819,0.250426779794862,"AGAP6","ArfGAP with GTPase domain, ankyrin repeat and PH domain 6",TRUE
+"240230_s_at",0.784925710185113,0.310041936935261,1.0389317071469,-5.42720283241028,0.707837145833804,"AGAP9","ArfGAP with GTPase domain, ankyrin repeat and PH domain 9",TRUE
+"238553_at",0.993846586666397,0.970851896195796,0.0369549073502564,-5.93901833748349,0.0193497808780725,"AGAP9///AGAP6///BMS1P5","ArfGAP with GTPase domain, ankyrin repeat and PH domain 9///ArfGAP with GTPase domain, ankyrin repeat and PH domain 6///BMS1, ribosome biogenesis factor pseudogene 5",TRUE
+"1553447_at",0.843637054204573,0.438984438813354,-0.788107995167172,-5.64160672667508,-0.522819323758105,"AGBL1","ATP/GTP binding protein like 1",TRUE
+"220390_at",0.463552233135475,0.023655673815206,2.42982860057825,-3.41223896790546,0.936437845435591,"AGBL2","ATP/GTP binding protein like 2",TRUE
+"232395_x_at",0.774230543658252,0.289235721044923,1.08581014160623,-5.38120084008036,0.899800195969727,"AGBL3","ATP/GTP binding protein like 3",TRUE
+"220649_at",0.841967750949524,0.434790679705161,0.795450825502708,-5.6361096581238,0.907925333496185,"AGBL3","ATP/GTP binding protein like 3",TRUE
+"1554820_at",0.979803152416153,0.903844521610237,-0.12219705648104,-5.93241321136004,-0.0986283327058644,"AGBL3","ATP/GTP binding protein like 3",TRUE
+"1553412_at",0.93928706246326,0.728145518414335,-0.352025136953564,-5.87950537461999,-0.257815427062131,"AGBL4","ATP/GTP binding protein like 4",TRUE
+"1569570_at",0.987915939622712,0.942229434522477,-0.0732944923889964,-5.93706727606849,-0.0482784612878708,"AGBL4","ATP/GTP binding protein like 4",TRUE
+"231857_s_at",0.657015752622694,0.125268750607592,1.59326055090662,-4.77357696519012,0.681822796351963,"AGBL5","ATP/GTP binding protein like 5",TRUE
+"218480_at",0.757950630724418,0.254371644448534,1.17015514822238,-5.29390292860949,0.509332644819745,"AGBL5","ATP/GTP binding protein like 5",TRUE
+"238889_at",0.977068283775465,0.890718142994431,0.138984227629345,-5.93027944678471,0.0601013943510873,"AGBL5","ATP/GTP binding protein like 5",TRUE
+"217046_s_at",0.666643938027574,0.13344794296036,1.55781112527785,-4.82213224581812,0.956541365022758,"AGER","advanced glycosylation end-product specific receptor",TRUE
+"210081_at",0.705559553212919,0.177631957018305,-1.39235707050075,-5.03712473482668,-1.2762317200027,"AGER","advanced glycosylation end-product specific receptor",TRUE
+"213928_s_at",0.554642754132296,0.051063049003796,2.06262759518707,-4.05606538537712,0.728601001811915,"AGFG1","ArfGAP with FG repeats 1",TRUE
+"218092_s_at",0.82653395242931,0.394740824249367,-0.86792146212498,-5.57929762297216,-0.309545161543765,"AGFG1","ArfGAP with FG repeats 1",TRUE
+"226561_at",0.843816788557882,0.439775269399738,0.786728173762842,-5.64263434640082,0.373121963882397,"AGFG1","ArfGAP with FG repeats 1",TRUE
+"213926_s_at",0.935316549043744,0.712311765626565,-0.373519699073727,-5.87195743214528,-0.166713476834071,"AGFG1","ArfGAP with FG repeats 1",TRUE
+"218091_at",0.984041243457591,0.921626266432086,0.0995124832960484,-5.93486137469765,0.037632145198792,"AGFG1","ArfGAP with FG repeats 1",TRUE
+"222362_at",0.474859593446097,0.026098872280502,-2.38423911839488,-3.49549655435657,-0.868305844410368,"AGFG2","ArfGAP with FG repeats 2",TRUE
+"1554618_at",0.705559553212919,0.177242652809182,1.3936614572567,-5.03550688451902,0.922920189573519,"AGFG2","ArfGAP with FG repeats 2",TRUE
+"206821_x_at",0.77547560202111,0.292726866940785,1.07777964936714,-5.38921011264226,0.446851653376589,"AGFG2","ArfGAP with FG repeats 2",TRUE
+"222126_at",0.85334340854827,0.461135075094077,0.750016899381956,-5.66935047766387,0.275290619526004,"AGFG2","ArfGAP with FG repeats 2",TRUE
+"217450_at",0.910888708415045,0.628437836351507,0.490736646094827,-5.82306357875034,0.375488752218089,"AGFG2","ArfGAP with FG repeats 2",TRUE
+"206820_at",0.933400538871064,0.705292776066996,0.383105114041441,-5.8684491908049,0.150231118077914,"AGFG2","ArfGAP with FG repeats 2",TRUE
+"218534_s_at",0.612420348961838,0.0841825721632624,-1.80811955225147,-4.46162232940053,-0.640729736527463,"AGGF1","angiogenic factor with G-patch and FHA domains 1",TRUE
+"222661_at",0.698391916012681,0.169387912974712,-1.42048063273143,-5.00196595057444,-0.453717060981475,"AGGF1","angiogenic factor with G-patch and FHA domains 1",TRUE
+"208042_at",0.711989638658417,0.185987179576396,-1.36489478515493,-5.07089462560397,-0.660637324856935,"AGGF1","angiogenic factor with G-patch and FHA domains 1",TRUE
+"210710_at",0.914776697425609,0.640999306248944,-0.472772721272534,-5.83140051243537,-0.186780730737627,"AGGF1","angiogenic factor with G-patch and FHA domains 1",TRUE
+"1555610_at",0.686108994812404,0.154630912355727,1.47369208716479,-4.93387286104282,1.08964052095411,"AGK","acylglycerol kinase",TRUE
+"222132_s_at",0.804714763494172,0.343757073912572,-0.967459039896706,-5.4938047840146,-0.284409328243814,"AGK","acylglycerol kinase",TRUE
+"218568_at",0.946257232656659,0.756470744368552,-0.313983464686949,-5.89177980637745,-0.0861895612387631,"AGK","acylglycerol kinase",TRUE
+"203566_s_at",0.813442508625161,0.363818499527814,-0.927189874290418,-5.52942052595556,-0.380458408097866,"AGL","amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase",TRUE
+"222930_s_at",0.85463333818278,0.466386588504463,0.741148490778021,-5.67562318667627,0.585724594379733,"AGMAT","agmatinase",TRUE
+"219792_at",0.863993702749895,0.490598696202811,0.701002528333293,-5.70313151847108,0.208375993052777,"AGMAT","agmatinase",TRUE
+"221648_s_at",0.947969282616012,0.763310630051044,0.304869842722902,-5.89451421505267,0.182745561951355,"AGMAT","agmatinase",TRUE
+"239036_at",0.731054546207485,0.21386797184854,1.27976020179261,-5.17198693325738,0.482116954020768,"AGO1","argonaute 1, RISC catalytic component",TRUE
+"222576_s_at",0.765400039004994,0.265594232871813,1.14212665605977,-5.32355164093646,0.383109386078983,"AGO1","argonaute 1, RISC catalytic component",TRUE
+"228120_at",0.832605695407954,0.409085190867651,0.841451640769113,-5.60058444031236,0.245309655097815,"AGO1","argonaute 1, RISC catalytic component",TRUE
+"218287_s_at",0.944705930911859,0.75131656415053,0.320868943986814,-5.88966101938081,0.0884943196960428,"AGO1","argonaute 1, RISC catalytic component",TRUE
+"225827_at",0.595019326272843,0.0719486384891245,1.88973375184567,-4.33560426483151,0.644602478060428,"AGO2","argonaute 2, RISC catalytic component",TRUE
+"228932_at",0.694519360341564,0.163987148419719,1.43950475974544,-4.97785583939485,0.597410773834378,"AGO3","argonaute 3, RISC catalytic component",TRUE
+"219426_at",0.789503009592599,0.316344680672526,1.02517272398456,-5.44035795744638,0.297976142794832,"AGO3","argonaute 3, RISC catalytic component",TRUE
+"235782_at",0.792436690618566,0.324006420311421,1.00870348118285,-5.45589596760607,0.674722161177185,"AGO3","argonaute 3, RISC catalytic component",TRUE
+"241091_at",0.809225441530816,0.3524330354592,0.949854016854705,-5.50954610413347,0.415038510078054,"AGO3","argonaute 3, RISC catalytic component",TRUE
+"227930_at",0.65284137151906,0.12192364905357,1.60831543622702,-4.75269857552654,0.614635730344682,"AGO4","argonaute 4, RISC catalytic component",TRUE
+"222842_at",0.903615659612912,0.605008905320942,0.524690543258438,-5.80647721322526,0.48214286791669,"AGO4","argonaute 4, RISC catalytic component",TRUE
+"1569408_at",0.966194888753897,0.842478505491467,-0.201069637004114,-5.9200111683825,-0.0851298884592433,"AGO4","argonaute 4, RISC catalytic component",TRUE
+"219190_s_at",0.970540753946729,0.859629827062415,-0.178915721108603,-5.92410419935587,-0.0767553010873145,"AGO4","argonaute 4, RISC catalytic component",TRUE
+"215535_s_at",0.860330607164155,0.479798588808115,0.718763824708938,-5.69114100616076,0.263580147003504,"AGPAT1","1-acylglycerol-3-phosphate O-acyltransferase 1",TRUE
+"32836_at",0.923358263835948,0.670863898904786,0.430676934686986,-5.84974331699512,0.134898914279386,"AGPAT1","1-acylglycerol-3-phosphate O-acyltransferase 1",TRUE
+"32837_at",0.868479826715457,0.504488693122687,-0.6784864858991,-5.71792033965537,-0.239271572996419,"AGPAT2","1-acylglycerol-3-phosphate O-acyltransferase 2",TRUE
+"210678_s_at",0.879948283821082,0.534749369940315,-0.630605553249758,-5.74783051202316,-0.256687897010302,"AGPAT2","1-acylglycerol-3-phosphate O-acyltransferase 2",TRUE
+"219723_x_at",0.599830488298384,0.076367993215273,1.85894809839309,-4.38360383117587,0.71542647056128,"AGPAT3","1-acylglycerol-3-phosphate O-acyltransferase 3",TRUE
+"224282_s_at",0.854593182713431,0.466203961441058,0.74145589973399,-5.67540693673651,0.401798208307522,"AGPAT3","1-acylglycerol-3-phosphate O-acyltransferase 3",TRUE
+"225440_at",0.8920930097751,0.562822026697976,0.587478712921589,-5.77296654539218,0.191759162878652,"AGPAT3","1-acylglycerol-3-phosphate O-acyltransferase 3",TRUE
+"223182_s_at",0.95877806139143,0.813264088711095,0.239050052513122,-5.91188855832186,0.100874473281396,"AGPAT3","1-acylglycerol-3-phosphate O-acyltransferase 3",TRUE
+"223183_at",0.958931830316768,0.814075378357299,0.237990727031595,-5.91213401831234,0.0963812814515901,"AGPAT3","1-acylglycerol-3-phosphate O-acyltransferase 3",TRUE
+"223184_s_at",0.985361089461736,0.927428939619328,-0.0921220345928052,-5.93555087962148,-0.0336625645176447,"AGPAT3","1-acylglycerol-3-phosphate O-acyltransferase 3",TRUE
+"228667_at",0.402463840838386,0.0147792251391873,2.64375407195651,-3.01062816550114,2.82485255558813,"AGPAT4","1-acylglycerol-3-phosphate O-acyltransferase 4",TRUE
+"219693_at",0.747173767557889,0.239040942700002,1.2099719665718,-5.25070587593201,1.09533124018759,"AGPAT4","1-acylglycerol-3-phosphate O-acyltransferase 4",TRUE
+"223740_at",0.907576524801672,0.616849763945007,0.507454862982503,-5.81503200259703,0.329733693582953,"AGPAT4-IT1","AGPAT4 intronic transcript 1",TRUE
+"218096_at",0.622434989367596,0.0929536470322261,1.75571750487171,-4.54041211060849,0.672099442630627,"AGPAT5","1-acylglycerol-3-phosphate O-acyltransferase 5",TRUE
+"232007_at",0.765647257565398,0.265894389688066,-1.14138912223632,-5.3243232727468,-0.541947074359906,"AGPAT5","1-acylglycerol-3-phosphate O-acyltransferase 5",TRUE
+"205401_at",0.562643595171948,0.0552902489243665,2.02311898417461,-4.121389685171,2.10322039129905,"AGPS","alkylglycerone phosphate synthase",TRUE
+"225108_at",0.574719648764943,0.0606306892377905,1.97688281878979,-4.19676822882427,2.02817756798346,"AGPS","alkylglycerone phosphate synthase",TRUE
+"225114_at",0.680708651141727,0.14864572956504,1.49645208996148,-4.90412910983475,2.28973837484901,"AGPS","alkylglycerone phosphate synthase",TRUE
+"225113_at",0.686747966354964,0.155278066864071,1.47127427043501,-4.93701095000479,2.09245000295323,"AGPS","alkylglycerone phosphate synthase",TRUE
+"228969_at",0.675622576285316,0.142014331751801,-1.52256019930822,-4.86956014675526,-2.27671357882866,"AGR2","anterior gradient 2, protein disulphide isomerase family member",TRUE
+"209173_at",0.844472871821284,0.441257347509141,-0.784146373273601,-5.64455258171625,-1.38258162698047,"AGR2","anterior gradient 2, protein disulphide isomerase family member",TRUE
+"228241_at",0.610486790071853,0.0832078852077385,-1.81423010334365,-4.45232522152726,-3.80838116504413,"AGR3","anterior gradient 3, protein disulphide isomerase family member",TRUE
+"212283_at",0.612420348961838,0.0839648516679103,1.809479166418,-4.45955565763893,1.19921500327591,"AGRN","agrin",TRUE
+"212285_s_at",0.708309103286544,0.180164533049893,1.38392657808186,-5.04755094306705,0.467659614803697,"AGRN","agrin",TRUE
+"217419_x_at",0.774230543658252,0.289916072062061,1.08423972105096,-5.3827712838306,0.455371488478431,"AGRN","agrin",TRUE
+"217410_at",0.789795896476304,0.318091149170375,-1.02139427269509,-5.44394287112881,-0.599812668517789,"AGRN","agrin",TRUE
+"207193_at",0.899162649244974,0.589475738446033,0.547548420820863,-5.79470305286812,0.480820068215261,"AGRP","agouti related neuropeptide",TRUE
+"202834_at",0.940044918888428,0.730898545860052,0.34830533421049,-5.88076676091054,0.159634681895874,"AGT","angiotensinogen",TRUE
+"204499_at",0.856257656023992,0.469780839481935,-0.735448013949541,-5.67961782979471,-0.641505628790398,"AGTPBP1","ATP/GTP binding protein 1",TRUE
+"204500_s_at",0.961212424803935,0.82304515001462,-0.226296868081241,-5.91477158038881,-0.106932981479389,"AGTPBP1","ATP/GTP binding protein 1",TRUE
+"208016_s_at",0.841967750949524,0.434322017287487,-0.796274110742251,-5.63549033127688,-0.941457550977594,"AGTR1","angiotensin II receptor type 1",TRUE
+"205357_s_at",0.974982245454858,0.878615769790853,0.154498019836273,-5.92806414309789,0.150296575199378,"AGTR1","angiotensin II receptor type 1",TRUE
+"207293_s_at",0.678044610516839,0.145257183776566,1.50967109049401,-4.88668597934201,1.03923791769618,"AGTR2","angiotensin II receptor type 2",TRUE
+"207294_at",0.89961817630669,0.590619099324238,-0.545855957279455,-5.79559157511496,-0.428199987755251,"AGTR2","angiotensin II receptor type 2",TRUE
+"222321_at",0.96200396340887,0.827285052201148,0.220780635093203,-5.91596988058194,0.194179702138535,"AGTR2","angiotensin II receptor type 2",TRUE
+"1555736_a_at",0.655745626967443,0.124272915122496,1.59770698079405,-4.7674264602363,0.642336886832624,"AGTRAP","angiotensin II receptor associated protein",TRUE
+"225059_at",0.696186551397464,0.166282582070407,1.4313585227039,-4.98821205960159,0.528666858310794,"AGTRAP","angiotensin II receptor associated protein",TRUE
+"238135_at",0.87754354850942,0.527816901841432,0.641440472119311,-5.74124609651139,0.357535071585916,"AGTRAP","angiotensin II receptor associated protein",TRUE
+"210327_s_at",0.971242929121865,0.86357972108215,0.173827111793055,-5.92497715405897,0.14753393653331,"AGXT","alanine-glyoxylate aminotransferase",TRUE
+"210326_at",0.972543181497623,0.867391555069905,0.168920815749811,-5.92579505240444,0.138397232315481,"AGXT","alanine-glyoxylate aminotransferase",TRUE
+"206957_at",0.986455005400648,0.937098786220789,-0.079817704231987,-5.9365809431848,-0.0642522261858147,"AGXT","alanine-glyoxylate aminotransferase",TRUE
+"229229_at",0.991254515545788,0.959124096990463,-0.0518357146091511,-5.93837485544089,-0.023580118242247,"AGXT2","alanine--glyoxylate aminotransferase 2",TRUE
+"226115_at",0.735378664395389,0.220324424352279,-1.2612860933223,-5.19319370450003,-0.525065650810326,"AHCTF1","AT-hook containing transcription factor 1",TRUE
+"214766_s_at",0.796466121438385,0.329141370367237,-0.99781699020079,-5.4660417124377,-0.36940120626504,"AHCTF1","AT-hook containing transcription factor 1",TRUE
+"1560224_at",0.991689960875868,0.961171033761791,-0.0492376936691387,-5.93850273800051,-0.0174374657704259,"AHCTF1P1///AHCTF1","AT-hook containing transcription factor 1 pseudogene 1///AT-hook containing transcription factor 1",TRUE
+"200903_s_at",0.874804570221732,0.521346723659898,0.651623030840064,-5.73495989507827,0.259511915411546,"AHCY","adenosylhomocysteinase",TRUE
+"200849_s_at",0.592584559127425,0.0697031256795062,-1.9060151484178,-4.30999566836564,-0.620641932534092,"AHCYL1","adenosylhomocysteinase like 1",TRUE
+"200848_at",0.642592458809121,0.113079851533823,-1.64985101122683,-4.69431108813667,-0.562870039451939,"AHCYL1","adenosylhomocysteinase like 1",TRUE
+"200850_s_at",0.739367922105944,0.227403667875457,-1.24150089192106,-5.21561232301988,-0.352845842798274,"AHCYL1","adenosylhomocysteinase like 1",TRUE
+"207464_at",0.774230543658252,0.28648110960962,-1.09219581123801,-5.37479421037777,-0.471394567602535,"AHCYL1","adenosylhomocysteinase like 1",TRUE
+"215672_s_at",0.638360409116684,0.109610014097621,-1.66689647876484,-4.67002016675224,-0.477590146031207,"AHCYL2","adenosylhomocysteinase like 2",TRUE
+"212814_at",0.770008266045778,0.278625396167346,-1.11065395464117,-5.35608766540452,-0.327382340548549,"AHCYL2","adenosylhomocysteinase like 2",TRUE
+"243793_at",0.280199223932988,0.00463810139252432,3.14838664708716,-2.0052508760491,1.57318025432632,"AHDC1","AT-hook DNA binding motif containing 1",TRUE
+"205002_at",0.734577729521114,0.21909651823631,1.26476721774651,-5.18921781495025,0.416406361367131,"AHDC1","AT-hook DNA binding motif containing 1",TRUE
+"229379_at",0.771875067712323,0.282082043492637,1.10248619845106,-5.36439970302736,0.400711355733353,"AHDC1","AT-hook DNA binding motif containing 1",TRUE
+"221569_at",0.194325783329824,0.00207542596871177,3.48632219724718,-1.29979210047537,1.44068158821034,"AHI1","Abelson helper integration site 1",TRUE
+"220841_s_at",0.304824368772306,0.00597916059898977,3.03992388904058,-2.22700669521789,1.31834080443071,"AHI1","Abelson helper integration site 1",TRUE
+"244699_at",0.512962828679001,0.0344133087442995,2.25405070721321,-3.72829307002669,1.68556645641702,"AHI1","Abelson helper integration site 1",TRUE
+"220842_at",0.672164152353115,0.138029172577541,1.53873483475975,-4.84790497287626,0.931211499262097,"AHI1","Abelson helper integration site 1",TRUE
+"232461_at",0.744573608322482,0.235831031297922,1.21855036576205,-5.24123489490801,1.14711895161751,"AHI1","Abelson helper integration site 1",TRUE
+"220016_at",0.505067985736837,0.0329013299522732,-2.2754061179066,-3.69062864747368,-2.06564219829646,"AHNAK","AHNAK nucleoprotein",TRUE
+"1563560_at",0.727318639756418,0.207716353767934,1.29776648523424,-5.15106451263639,0.654891443793348,"AHNAK","AHNAK nucleoprotein",TRUE
+"211986_at",0.901781358899845,0.599109393336589,-0.533338041891633,-5.80208028707693,-0.235678629939553,"AHNAK","AHNAK nucleoprotein",TRUE
+"238855_at",0.963379172403332,0.832875720442494,0.213517681990363,-5.91750273285638,0.168874040804012,"AHNAK","AHNAK nucleoprotein",TRUE
+"235281_x_at",0.995113346376719,0.977581705936446,-0.0284198753679461,-5.93929009271959,-0.0208765087566576,"AHNAK","AHNAK nucleoprotein",TRUE
+"212992_at",0.539114280228505,0.0441526560547519,2.1340152823412,-3.93596288343951,1.93224252544449,"AHNAK2","AHNAK nucleoprotein 2",TRUE
+"1558378_a_at",0.565043084457947,0.0561712197910516,2.0152258035959,-4.13434028073152,1.45412458240048,"AHNAK2","AHNAK nucleoprotein 2",TRUE
+"202820_at",0.589993177920356,0.0681014530563396,1.91791173406379,-4.29118716348135,1.23752971118308,"AHR","aryl hydrocarbon receptor",TRUE
+"229354_at",0.871078207533268,0.511542370141347,-0.667186420043466,-5.72516834612695,-0.466547764617023,"AHRR","aryl-hydrocarbon receptor repressor",TRUE
+"201491_at",0.870084233343568,0.508301060763181,-0.672368109745576,-5.72185920905172,-0.202088285413208,"AHSA1","activator of Hsp90 ATPase activity 1",TRUE
+"226665_at",0.468735421183467,0.025076963742944,2.40280627076109,-3.46169326788463,1.6858995261094,"AHSA2","AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)",TRUE
+"226334_s_at",0.544819033181092,0.0467780479471755,2.10578390204871,-3.98377231001663,0.760244700079948,"AHSA2","AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)",TRUE
+"230148_at",0.728385463227073,0.209416131054593,1.29275030902356,-5.15691803174838,0.853568870085313,"AHSA2","AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)",TRUE
+"212980_at",0.979388236370534,0.900648644903698,0.126280726327402,-5.93191935533136,0.0681823132276316,"AHSA2","AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)",TRUE
+"204551_s_at",0.732320150624823,0.216599557392574,-1.27189257836835,-5.18105052493778,-0.882974442213742,"AHSG","alpha 2-HS glycoprotein",TRUE
+"210929_s_at",0.784925710185113,0.309954541624867,1.03912387144004,-5.42701798284285,0.687796812088371,"AHSG","alpha 2-HS glycoprotein",TRUE
+"219672_at",0.45647012846614,0.0222876393592888,-2.45729883693487,-3.36165757311771,-1.13816281950273,"AHSP","alpha hemoglobin stabilizing protein",TRUE
+"219841_at",0.610660880283135,0.0833264088123894,1.81348375244532,-4.45346199664804,1.74595472474779,"AICDA","activation-induced cytidine deaminase",TRUE
+"224499_s_at",0.857316604145187,0.472537437378325,-0.730836327058214,-5.68282807554812,-0.862347682392926,"AICDA","activation-induced cytidine deaminase",TRUE
+"226801_s_at",0.715493644680006,0.191212969874772,1.34821064140124,-5.09113695090122,0.356192888858313,"AIDA","axin interactor, dorsalization associated",TRUE
+"220199_s_at",0.83364851657447,0.411208255929459,0.837584577834342,-5.6036428069748,0.233437679270374,"AIDA","axin interactor, dorsalization associated",TRUE
+"213095_x_at",0.884749233889577,0.544265307480634,0.615855322733844,-5.75662068301205,0.173105696179495,"AIF1","allograft inflammatory factor 1",TRUE
+"215051_x_at",0.942715939525446,0.743568813754639,-0.33124915176283,-5.88638084779462,-0.104164766135515,"AIF1","allograft inflammatory factor 1",TRUE
+"209901_x_at",0.943464796017993,0.746971232046838,0.326686188279763,-5.88783548677404,0.0940659926730096,"AIF1","allograft inflammatory factor 1",TRUE
+"207823_s_at",0.988776423002819,0.946013142008863,0.0684859120334631,-5.93739925692389,0.0540639571537547,"AIF1","allograft inflammatory factor 1",TRUE
+"223074_s_at",0.7717895132349,0.281801240270726,-1.10314699285,-5.36372926161732,-1.22163769884581,"AIF1L","allograft inflammatory factor 1 like",TRUE
+"223075_s_at",0.904957976522052,0.610536199727294,-0.516625240453725,-5.81051502373744,-0.427558585407843,"AIF1L","allograft inflammatory factor 1 like",TRUE
+"205512_s_at",0.449963242595417,0.0214961863677957,-2.47391495393286,-3.33091427583762,-0.866450169256089,"AIFM1","apoptosis inducing factor, mitochondria associated 1",TRUE
+"224461_s_at",0.544906350194399,0.0468116164035316,2.10543225827668,-3.98436525424477,2.88948357736608,"AIFM2","apoptosis inducing factor, mitochondria associated 2",TRUE
+"228445_at",0.595925222489779,0.072263085964467,1.88748943905577,-4.33912223041181,1.43884025761721,"AIFM2","apoptosis inducing factor, mitochondria associated 2",TRUE
+"244084_at",0.724970327905974,0.202707959312724,-1.31273419880039,-5.13348411830766,-0.750385978683961,"AIFM3","apoptosis inducing factor, mitochondria associated 3",TRUE
+"232810_at",0.627092759817312,0.0984854072423381,1.72481329461634,-4.58607777761481,0.845547957628905,"AIG1","androgen induced 1",TRUE
+"230520_at",0.842917136850585,0.436752272884588,0.792010880236376,-5.63869088020071,0.287954716035506,"AIG1","androgen induced 1",TRUE
+"223136_at",0.973071267819624,0.870692198922536,0.16467591427709,-5.92648385142988,0.0908560725086485,"AIG1","androgen induced 1",TRUE
+"212543_at",0.733981824228023,0.218181669883126,1.26737056546473,-5.18623833180427,1.06287508554089,"AIM1","absent in melanoma 1",TRUE
+"220289_s_at",0.55937703282623,0.0534060971947749,2.04038343800612,-4.09294657461873,1.81997423314873,"AIM1L","absent in melanoma 1-like",TRUE
+"220290_at",0.689168483917391,0.158203177198998,1.46044670055256,-4.95101288336765,0.66352400846417,"AIM1L","absent in melanoma 1-like",TRUE
+"206513_at",0.228900728752571,0.00288931256349384,3.34815576344024,-1.59054759762146,3.2306211064485,"AIM2","absent in melanoma 2",TRUE
+"202541_at",0.783215903203604,0.305745092478994,-1.04842527731284,-5.41803386127325,-0.341687611461378,"AIMP1","aminoacyl tRNA synthetase complex interacting multifunctional protein 1",TRUE
+"202542_s_at",0.851733415458562,0.456355625732481,-0.758140695482695,-5.66354244652483,-0.20284272873671,"AIMP1","aminoacyl tRNA synthetase complex interacting multifunctional protein 1",TRUE
+"227605_at",0.877740599174557,0.528434404367316,-0.640472240582488,-5.74183888174169,-0.226737560358869,"AIMP1","aminoacyl tRNA synthetase complex interacting multifunctional protein 1",TRUE
+"209972_s_at",0.707818577910656,0.179453683185677,1.3862833130889,-5.04464159034908,0.356203962262078,"AIMP2","aminoacyl tRNA synthetase complex interacting multifunctional protein 2",TRUE
+"209971_x_at",0.812505689959838,0.361101695126045,0.932554232907956,-5.52475629189838,0.301422608585861,"AIMP2","aminoacyl tRNA synthetase complex interacting multifunctional protein 2",TRUE
+"202138_x_at",0.86632010667518,0.497202148109399,0.690253527298535,-5.71024911163949,0.2365183061733,"AIMP2","aminoacyl tRNA synthetase complex interacting multifunctional protein 2",TRUE
+"201781_s_at",0.820288124919738,0.378370433525184,-0.89890178244202,-5.55360621258301,-0.338238641305432,"AIP","aryl hydrocarbon receptor interacting protein",TRUE
+"201782_s_at",0.985709215004606,0.931069954857782,-0.087487443902157,-5.93595616131759,-0.0305777173390318,"AIP","aryl hydrocarbon receptor interacting protein",TRUE
+"235731_at",0.600563690098577,0.0765931524656127,1.85742162059534,-4.38596933776393,0.981075259109183,"AIPL1","aryl hydrocarbon receptor interacting protein like 1",TRUE
+"219977_at",0.956734254923335,0.803641029609516,0.251636891708154,-5.9088890696929,0.115180113538473,"AIPL1","aryl hydrocarbon receptor interacting protein like 1",TRUE
+"208090_s_at",0.691295036264984,0.161011471193822,1.4502029172841,-4.96418257862168,0.858823498811129,"AIRE","autoimmune regulator",TRUE
+"206460_at",0.509163975230892,0.0338475214867403,2.26193972298432,-3.71440380518693,1.32853935300471,"AJAP1","adherens junctions associated protein 1",TRUE
+"215149_at",0.682539393883246,0.150441072965668,1.48954772925697,-4.91319080030789,0.960520242826656,"AJAP1","adherens junctions associated protein 1",TRUE
+"215790_at",0.830635993561085,0.404354102988585,0.850115295105926,-5.59368484390107,0.302260998371992,"AJAP1","adherens junctions associated protein 1",TRUE
+"215789_s_at",0.901788521024914,0.599647730513775,0.532547249088969,-5.80248528102052,0.321714323237224,"AJAP1","adherens junctions associated protein 1",TRUE
+"225807_at",0.643082025527735,0.113432252826951,1.64814460869452,-4.69673232548843,0.870367096667092,"AJUBA","ajuba LIM protein",TRUE
+"225806_at",0.808266620412549,0.351138245352907,0.952462553119571,-5.50723040970658,0.519681542493887,"AJUBA","ajuba LIM protein",TRUE
+"1553764_a_at",0.89748872632674,0.584266361813698,0.555280228139206,-5.79060997504966,0.328576599115081,"AJUBA","ajuba LIM protein",TRUE
+"243446_at",0.901154557823402,0.597583448678115,0.535581458961694,-5.80092816935555,0.425176388683965,"AJUBA","ajuba LIM protein",TRUE
+"202587_s_at",0.532405994061663,0.0419079009535168,-2.1593806402421,-3.89266474604485,-0.789585141161687,"AK1","adenylate kinase 1",TRUE
+"202588_at",0.708473702007515,0.180448005058025,-1.38298882063702,-5.04870744851133,-0.825674072445533,"AK1","adenylate kinase 1",TRUE
+"205996_s_at",0.740476003158683,0.229695415157776,1.23519661181075,-5.22269165949573,0.532659714714841,"AK2","adenylate kinase 2",TRUE
+"212172_at",0.760905446901853,0.259954541676699,1.15609992300899,-5.30884952290433,0.595378419391753,"AK2","adenylate kinase 2",TRUE
+"212173_at",0.808257777979515,0.350885259480598,0.952972988913931,-5.50677659648687,0.528065123680511,"AK2","adenylate kinase 2",TRUE
+"212174_at",0.822173415758858,0.386347927307682,0.883697728688855,-5.56631903747253,0.478084722171463,"AK2","adenylate kinase 2",TRUE
+"212175_s_at",0.846898808963473,0.445521180297858,-0.77674816650315,-5.65001640834696,-0.264575383087246,"AK2","adenylate kinase 2",TRUE
+"208967_s_at",0.87927534655779,0.533230506655185,-0.632972883520286,-5.7464010887949,-0.197521088607719,"AK2","adenylate kinase 2",TRUE
+"224655_at",0.963674437670438,0.834162233408849,0.211848022098278,-5.91784790025497,0.12446632345873,"AK3","adenylate kinase 3",TRUE
+"224151_s_at",0.971282250892504,0.863804365107081,-0.173537847556723,-5.92502602322899,-0.118653704681831,"AK3","adenylate kinase 3",TRUE
+"219308_s_at",0.929234395612144,0.688889064842138,-0.405651833164022,-5.85985184990077,-0.361398718140823,"AK5","adenylate kinase 5",TRUE
+"222862_s_at",0.933227785561424,0.704647544150031,0.383988091962474,-5.86812161376731,0.310116084833605,"AK5","adenylate kinase 5",TRUE
+"203893_at",0.673322568613087,0.139024023357533,-1.53466140325842,-4.85337574433234,-0.55638893389489,"AK6","adenylate kinase 6",TRUE
+"202168_at",0.920783004321385,0.663177246077584,-0.441433314582173,-5.84521582233571,-0.177131372314161,"AK6///TAF9","adenylate kinase 6///TATA-box binding protein associated factor 9",TRUE
+"1569700_s_at",0.897024165042344,0.583086215374575,-0.557036560331203,-5.78967243936872,-0.401010627549607,"AK7","adenylate kinase 7",TRUE
+"241326_at",0.919485127002411,0.658051763849879,0.448635138987827,-5.84212323170704,0.128520203215472,"AK7","adenylate kinase 7",TRUE
+"1569699_at",0.932625096890813,0.702389412479936,0.387080722605264,-5.86696841328079,0.133277866925369,"AK7","adenylate kinase 7",TRUE
+"1553734_at",0.956462414390747,0.802797333893767,-0.252742388498931,-5.90861831844884,-0.325063727488335,"AK7","adenylate kinase 7",TRUE
+"230976_at",0.823816057511545,0.391089663414,-0.874757576338407,-5.57370044020681,-0.487022508570851,"AK8","adenylate kinase 8",TRUE
+"1557666_s_at",0.97689149311934,0.889848846891226,0.140097351170872,-5.93012828139623,0.0470946807251753,"AK8","adenylate kinase 8",TRUE
+"239828_at",0.592271487526151,0.0693393651880181,1.90869579812479,-4.30576465943802,0.802670255717993,"AK9","adenylate kinase 9",TRUE
+"1552299_at",0.789378278298554,0.315932552289029,-1.0260664878225,-5.4395082251371,-0.558707574535903,"AK9","adenylate kinase 9",TRUE
+"1564002_a_at",0.948429371744093,0.764976132819236,-0.302654702218631,-5.89516677832345,-0.186953623849395,"AK9","adenylate kinase 9",TRUE
+"243506_at",0.973071267819624,0.870521371404394,-0.164895535944021,-5.92644864338265,-0.157131617318875,"AKAIN1","A kinase (PRKA) anchor inhibitor 1",TRUE
+"210625_s_at",0.741260241503758,0.231675637794391,1.22978769292529,-5.2287407948408,0.594038190734484,"AKAP1","A-kinase anchoring protein 1",TRUE
+"201674_s_at",0.742555047880744,0.232814360122729,1.2266931825198,-5.23219127808311,0.52479269617084,"AKAP1","A-kinase anchoring protein 1",TRUE
+"201675_at",0.829803290928719,0.401519998745017,0.855336219784843,-5.58949516331472,0.336071127766836,"AKAP1","A-kinase anchoring protein 1",TRUE
+"210626_at",0.87324988329021,0.51792861847892,0.657030368879304,-5.73158304694233,0.381342096175174,"AKAP1","A-kinase anchoring protein 1",TRUE
+"236007_at",0.592488489935347,0.0695353469945813,1.9072500264523,-4.30804711014523,0.812840126232949,"AKAP10","A-kinase anchoring protein 10",TRUE
+"205045_at",0.697871681043328,0.168768421152392,1.42263784535462,-4.99924523161212,0.418079263207908,"AKAP10","A-kinase anchoring protein 10",TRUE
+"236006_s_at",0.736132227107113,0.22149262487529,1.25798801310646,-5.19695187607262,0.526117110372851,"AKAP10","A-kinase anchoring protein 10",TRUE
+"213396_s_at",0.866077812635028,0.496763273091672,0.690965382411069,-5.70978099357085,0.263388443610353,"AKAP10","A-kinase anchoring protein 10",TRUE
+"215336_at",0.739367922105944,0.227357215722468,1.2416291745243,-5.21546794711079,0.444973787927921,"AKAP11","A-kinase anchoring protein 11",TRUE
+"203156_at",0.870808709484996,0.510457274615556,0.668919048468417,-5.72406458105129,0.203072183325542,"AKAP11","A-kinase anchoring protein 11",TRUE
+"227530_at",0.327864702134751,0.00772567857089571,2.92941135449586,-2.45006865179167,3.08076453931737,"AKAP12","A-kinase anchoring protein 12",TRUE
+"227529_s_at",0.353676416701777,0.00943137111204738,2.8425387062667,-2.62314266520027,4.80078264767767,"AKAP12","A-kinase anchoring protein 12",TRUE
+"231067_s_at",0.40221114169538,0.0145534088700938,2.65064947428659,-2.99740359516239,3.17787344430394,"AKAP12","A-kinase anchoring protein 12",TRUE
+"210517_s_at",0.423421354964585,0.0177803112828859,2.56045985448985,-3.16904587222405,3.99072082232508,"AKAP12","A-kinase anchoring protein 12",TRUE
+"1555395_at",0.969183235742461,0.853982281589312,-0.186199841119204,-5.92281091125936,-0.106564091368516,"AKAP12","A-kinase anchoring protein 12",TRUE
+"221718_s_at",0.568535987826756,0.0579506366741382,1.99961300809369,-4.15985723556762,0.935247286741291,"AKAP13","A-kinase anchoring protein 13",TRUE
+"222024_s_at",0.581128536542197,0.0636257711760417,1.95251008998506,-4.23602867789405,0.829149353195511,"AKAP13","A-kinase anchoring protein 13",TRUE
+"209534_x_at",0.594005743610726,0.0709514104092172,1.89690852849404,-4.32433815493461,0.554360829172069,"AKAP13","A-kinase anchoring protein 13",TRUE
+"208324_at",0.623667408398064,0.0948526445434733,1.74493514787318,-4.55641289134225,0.61919001737777,"AKAP13","A-kinase anchoring protein 13",TRUE
+"227039_at",0.628892275677877,0.0999273185010754,1.71700191028578,-4.59752476001128,0.514276152430121,"AKAP13","A-kinase anchoring protein 13",TRUE
+"208325_s_at",0.689985677226298,0.159479799914114,1.45577190875747,-4.95703227044227,0.663777188448113,"AKAP13","A-kinase anchoring protein 13",TRUE
+"232188_at",0.718209712149641,0.194078319480668,1.33921437604956,-5.10196532207546,0.528650653297754,"AKAP13","A-kinase anchoring protein 13",TRUE
+"224884_at",0.741260241503758,0.231829431793987,1.2293690803376,-5.22920800085797,0.482459889759548,"AKAP13","A-kinase anchoring protein 13",TRUE
+"222023_at",0.870084233343568,0.508292749230019,-0.672381420640116,-5.72185067686939,-0.403176920169333,"AKAP13","A-kinase anchoring protein 13",TRUE
+"229783_at",0.871708868449496,0.513294670802611,0.664392753726902,-5.72694226597279,0.425195991932984,"AKAP13","A-kinase anchoring protein 13",TRUE
+"213516_at",0.919959462096257,0.659333573478511,-0.446831819637783,-5.84290221642131,-0.250734711268991,"AKAP13","A-kinase anchoring protein 13",TRUE
+"242698_at",0.660093442228076,0.128077913430517,1.58087424589606,-4.79063975723451,1.15070555159688,"AKAP14","A-kinase anchoring protein 14",TRUE
+"237281_at",0.797963285726587,0.332171809338129,0.991447365079797,-5.47193157781758,0.90717954863649,"AKAP14","A-kinase anchoring protein 14",TRUE
+"237282_s_at",0.801560848966415,0.338596733129304,-0.978074343546661,-5.48418567638092,-0.818823528761348,"AKAP14","A-kinase anchoring protein 14",TRUE
+"203624_at",0.65284137151906,0.12208733118916,-1.60757080071393,-4.75373483272945,-0.527346396151124,"AKAP17A","A-kinase anchoring protein 17A",TRUE
+"210269_s_at",0.748438284778152,0.241311423893427,-1.20395648137313,-5.25731265941243,-0.552217415365471,"AKAP17A","A-kinase anchoring protein 17A",TRUE
+"228447_at",0.979347742195592,0.900164700070101,-0.126899297825223,-5.93184313527528,-0.056750676979946,"AKAP17A","A-kinase anchoring protein 17A",TRUE
+"207344_at",0.718706241731185,0.194597080944031,1.33759679607207,-5.10390587398075,0.395630572321535,"AKAP3","A-kinase anchoring protein 3",TRUE
+"207019_s_at",0.921199576190399,0.664160204042853,0.440054876833547,-5.84580214853537,0.276857233604302,"AKAP4","A-kinase anchoring protein 4",TRUE
+"230846_at",0.786221214160608,0.311612504999732,-1.03548484663672,-5.43051325804356,-1.07822095856892,"AKAP5","A-kinase anchoring protein 5",TRUE
+"207800_at",0.89767014756104,0.584803163895321,0.55448192603459,-5.79103516125976,0.570225248849117,"AKAP5","A-kinase anchoring protein 5",TRUE
+"205359_at",0.849646596450765,0.451021547303047,0.76726783448911,-5.65694650791036,0.247993929172048,"AKAP6","A-kinase anchoring protein 6",TRUE
+"217669_s_at",0.931582451098271,0.69796319321001,0.393153864644271,-5.86467729145752,0.164518663280707,"AKAP6","A-kinase anchoring protein 6",TRUE
+"205771_s_at",0.567651250567208,0.0577708237173267,2.00117121079688,-4.15731652970023,1.11667355457946,"AKAP7","A-kinase anchoring protein 7",TRUE
+"205772_s_at",0.729083413548563,0.210869992156253,1.28848479546492,-5.16188042738181,0.599892996957297,"AKAP7","A-kinase anchoring protein 7",TRUE
+"211172_x_at",0.936992192746977,0.718236286277562,-0.365456619607858,-5.87484057975454,-0.135930083839062,"AKAP7","A-kinase anchoring protein 7",TRUE
+"203848_at",0.762857166457304,0.262523699012085,1.14970695005332,-5.31559546593658,0.360675738988107,"AKAP8","A-kinase anchoring protein 8",TRUE
+"203847_s_at",0.784552021081681,0.308118797728481,1.04316916717377,-5.42311952880705,0.316813817591573,"AKAP8","A-kinase anchoring protein 8",TRUE
+"240554_at",0.832605695407954,0.408982976819473,0.841638140330366,-5.60043660977016,0.61550139704587,"AKAP8L","A-kinase anchoring protein 8 like",TRUE
+"215741_x_at",0.867026157046741,0.498643335307882,-0.687918434257396,-5.71178144050995,-0.440207129218388,"AKAP8L","A-kinase anchoring protein 8 like",TRUE
+"218064_s_at",0.873714994839466,0.51946155995123,-0.654602875620701,-5.73310231290003,-0.272864327417093,"AKAP8L","A-kinase anchoring protein 8 like",TRUE
+"227691_at",0.907964244160782,0.618149524389532,0.505572461857284,-5.81594944161561,0.447736734377984,"AKAP8L","A-kinase anchoring protein 8 like",TRUE
+"222160_at",0.95018792835023,0.773567753508527,0.291251977684353,-5.89845127635183,0.191128733855083,"AKAP8L","A-kinase anchoring protein 8 like",TRUE
+"207870_at",0.93032716386748,0.691871294742074,0.401537193138724,-5.86145692114375,0.273985678717934,"AKAP9","A-kinase anchoring protein 9",TRUE
+"215483_at",0.954456115752166,0.791246891840649,0.267910022240707,-5.90478448523251,0.148614005241305,"AKAP9","A-kinase anchoring protein 9",TRUE
+"210962_s_at",0.990627530017502,0.952755347427779,-0.0599215052051182,-5.93793478962211,-0.0250689458054367,"AKAP9","A-kinase anchoring protein 9",TRUE
+"242515_x_at",0.854921010321791,0.466934635760939,0.740226412833225,-5.67627132163582,0.21494654267252,"AKIP1","A-kinase interacting protein 1",TRUE
+"219953_s_at",0.968682165644631,0.852582042526766,0.188007429004552,-5.92248201069301,0.0631178769736884,"AKIP1","A-kinase interacting protein 1",TRUE
+"217893_s_at",0.901781358899845,0.59872362480329,-0.533904930023568,-5.80178960313126,-0.166016546476012,"AKIRIN1","akirin 1",TRUE
+"222459_at",0.951934441578502,0.779847779606345,-0.282942140163854,-5.90076607817283,-0.0929055091044138,"AKIRIN1","akirin 1",TRUE
+"222458_s_at",0.975196332002567,0.87932788920391,-0.153584130451518,-5.92820112051362,-0.0545900968976927,"AKIRIN1","akirin 1",TRUE
+"223145_s_at",0.688234475234403,0.157615524928499,1.46260885559391,-4.94822353841703,0.590430054955803,"AKIRIN2","akirin 2",TRUE
+"223143_s_at",0.83872852514497,0.424120315991857,0.814333323763293,-5.6217536945063,0.462889433971991,"AKIRIN2","akirin 2",TRUE
+"223144_s_at",0.852006864319744,0.457187781549293,0.756722596313773,-5.6645605688976,0.246320355035975,"AKIRIN2","akirin 2",TRUE
+"213810_s_at",0.970353888480813,0.858865602396746,-0.179900818384369,-5.92393230424785,-0.10328127127378,"AKIRIN2","akirin 2",TRUE
+"225701_at",0.615821255316333,0.0864746105251907,1.79398771013483,-4.48303667316615,1.6870034485822,"AKNA","AT-hook transcription factor",TRUE
+"1558565_at",0.874474734833648,0.520660534378846,-0.652706989985597,-5.73428511541655,-0.474755273158458,"AKNA","AT-hook transcription factor",TRUE
+"1552933_at",0.639375236152764,0.109918338482072,1.66536355895876,-4.67221246026713,0.626174090148377,"AKNAD1","AKNA domain containing 1",TRUE
+"1558834_s_at",0.823074246722209,0.389897082580799,-0.876999423188867,-5.57185601109633,-0.878068347332327,"AKNAD1","AKNA domain containing 1",TRUE
+"1563834_a_at",0.909069952277897,0.622896074316486,0.498713815942854,-5.81926403955129,0.363361895642927,"AKNAD1","AKNA domain containing 1",TRUE
+"201900_s_at",0.884815577925557,0.544854512938307,-0.614946564729,-5.75715568711058,-0.294404033424305,"AKR1A1","aldo-keto reductase family 1 member A1",TRUE
+"241978_at",0.92148618812595,0.665415023686999,0.438296455104418,-5.84654749054099,0.133087288214952,"AKR1A1","aldo-keto reductase family 1 member A1",TRUE
+"201272_at",0.387357699611418,0.012823364175522,2.70709505067904,-2.88853969298211,4.61294338257718,"AKR1B1","aldo-keto reductase family 1 member B",TRUE
+"206561_s_at",0.756207119282867,0.251106543047415,1.17848174711813,-5.28497370755304,1.54899592421037,"AKR1B10","aldo-keto reductase family 1 member B10",TRUE
+"204151_x_at",0.683805950121197,0.152584019791739,1.48139391758897,-4.92384890332439,2.06698796948313,"AKR1C1","aldo-keto reductase family 1 member C1",TRUE
+"216594_x_at",0.703581041988101,0.175216451169821,1.40048744310431,-5.02702009738982,1.84793534312441,"AKR1C1","aldo-keto reductase family 1 member C1",TRUE
+"217626_at",0.84932977991296,0.450344741770226,0.768430566772039,-5.65610087671772,0.754742950221331,"AKR1C1","aldo-keto reductase family 1 member C1",TRUE
+"1555855_at",0.946117279139627,0.755907473336192,-0.314735180087774,-5.89155070338135,-0.16582701203228,"AKR1C1","aldo-keto reductase family 1 member C1",TRUE
+"1555856_s_at",0.990810941805126,0.95654218605279,0.0551132613219408,-5.93820414862309,0.0245183167002008,"AKR1C1","aldo-keto reductase family 1 member C1",TRUE
+"209160_at",0.548055506319763,0.0483122193373716,2.08993965764157,-4.01042590802107,3.82703325713839,"AKR1C3","aldo-keto reductase family 1, member C3",TRUE
+"210558_at",0.599731655615302,0.0761870654429303,1.86017755087544,-4.38169760801555,1.62595528660901,"AKR1C4","aldo-keto reductase family 1, member C4",TRUE
+"224070_at",0.73223722457785,0.216123033487037,1.27325956013919,-5.17947917042728,0.644659914233176,"AKR1C6P","aldo-keto reductase family 1 member C6, pseudogene",TRUE
+"207102_at",0.923494952314901,0.671722284151749,0.42947896901166,-5.85024076772504,0.241213372616986,"AKR1D1","aldo-keto reductase family 1, member D1",TRUE
+"1555220_a_at",0.64030781048631,0.110965041869208,1.66018651907606,-4.67960501609569,2.02946306461976,"AKR1E2","aldo-keto reductase family 1 member E2",TRUE
+"1559982_s_at",0.76029267756668,0.258810337323632,1.15896215369404,-5.3058186170029,0.421006831884651,"AKR1E2","aldo-keto reductase family 1 member E2",TRUE
+"223856_at",0.839519981963042,0.427330620634397,0.808621545841733,-5.62612959845835,0.805093248188885,"AKR1E2","aldo-keto reductase family 1 member E2",TRUE
+"214259_s_at",0.829803290928719,0.401395924162522,-0.855565326098037,-5.58931076293896,-0.381139862968539,"AKR7A2","aldo-keto reductase family 7 member A2",TRUE
+"202139_at",0.883515015273005,0.541803398283851,-0.61965810828301,-5.75437364666085,-0.296449367875841,"AKR7A2","aldo-keto reductase family 7 member A2",TRUE
+"216381_x_at",0.598790786356002,0.0757444791102659,-1.86319580279725,-4.37701412669616,-0.845234543482793,"AKR7A3","aldo-keto reductase family 7 member A3",TRUE
+"206469_x_at",0.696090594363684,0.166119617288658,-1.43193387430112,-4.98748219875662,-0.685840675845846,"AKR7A3","aldo-keto reductase family 7 member A3",TRUE
+"207163_s_at",0.627092759817312,0.0983794374498992,-1.72539121288417,-4.58522934367725,-0.862318633456397,"AKT1","AKT serine/threonine kinase 1",TRUE
+"224982_at",0.921729477898827,0.666467876797796,-0.436822138843238,-5.84717015100058,-0.149730824439166,"AKT1S1","AKT1 substrate 1",TRUE
+"1555821_a_at",0.944654135079729,0.751166857759745,0.321069172109049,-5.88959872459553,0.127978310134813,"AKT1S1","AKT1 substrate 1",TRUE
+"225471_s_at",0.612420348961838,0.0840765988571537,-1.8087809507108,-4.46061711566923,-0.467116409535405,"AKT2","AKT serine/threonine kinase 2",TRUE
+"236664_at",0.711989638658417,0.18589324877738,1.36519803881932,-5.07052477551808,0.404926212384012,"AKT2","AKT serine/threonine kinase 2",TRUE
+"1560689_s_at",0.768852835478002,0.272020298584064,1.12646864888971,-5.33983910688361,0.746649897885924,"AKT2","AKT serine/threonine kinase 2",TRUE
+"211453_s_at",0.833115970971464,0.410305246772656,0.839227812768363,-5.60234481991538,0.771857830681823,"AKT2","AKT serine/threonine kinase 2",TRUE
+"203808_at",0.920377252397623,0.661126952888858,0.44431131815496,-5.8439858469269,0.166345211439357,"AKT2","AKT serine/threonine kinase 2",TRUE
+"226156_at",0.93763407082406,0.724110723361086,0.35748600111445,-5.87762961016018,0.153657400948934,"AKT2","AKT serine/threonine kinase 2",TRUE
+"203809_s_at",0.964263441785771,0.835661001799634,0.209903669425644,-5.91824645422868,0.0879066992170223,"AKT2","AKT serine/threonine kinase 2",TRUE
+"224229_s_at",0.615821255316333,0.0862409164147373,1.79541367098132,-4.48088140851395,2.11692050201821,"AKT3","AKT serine/threonine kinase 3",TRUE
+"212607_at",0.636735889029978,0.107817116792676,1.67588325218778,-4.65713699589148,1.99720170010607,"AKT3","AKT serine/threonine kinase 3",TRUE
+"212609_s_at",0.656723416459198,0.124887636499256,1.59495874400511,-4.77122952184845,1.75963622152328,"AKT3","AKT serine/threonine kinase 3",TRUE
+"219393_s_at",0.66927199146331,0.135344397755902,1.5498496945465,-4.83291891311849,0.917849949967408,"AKT3","AKT serine/threonine kinase 3",TRUE
+"222880_at",0.728885229071883,0.210406869143878,1.28984108632672,-5.16030406304475,1.29955046221241,"AKT3","AKT serine/threonine kinase 3",TRUE
+"242879_x_at",0.7768734672127,0.294503307480245,1.07371977342195,-5.39323904896198,0.661501771025756,"AKT3","AKT serine/threonine kinase 3",TRUE
+"242876_at",0.842224301155785,0.43577342505171,0.793726242332114,-5.63740504437742,0.339835877560263,"AKT3","AKT serine/threonine kinase 3",TRUE
+"223894_s_at",0.765934384067577,0.266286591334307,-1.14042634197823,-5.32532990387959,-0.424431402032885,"AKTIP","AKT interacting protein",TRUE
+"218373_at",0.79985507957204,0.335332018910842,-0.98484757488504,-5.47799809258037,-0.467721910325027,"AKTIP","AKT interacting protein",TRUE
+"218487_at",0.407748633394319,0.0156785090415439,-2.61724273195718,-3.06131935629937,-0.970101334735842,"ALAD","aminolevulinate dehydratase",TRUE
+"218489_s_at",0.626868719017002,0.0973867928546944,-1.73083066837078,-4.57723338587849,-0.739170924750714,"ALAD","aminolevulinate dehydratase",TRUE
+"205633_s_at",0.965051562536751,0.837648870659471,-0.207326081582448,-5.91876916784617,-0.0759802706138384,"ALAS1","5'-aminolevulinate synthase 1",TRUE
+"244205_at",0.841420204214686,0.432462932077937,0.7995453282061,-5.63302356407459,0.519893019410846,"ALAS2","5'-aminolevulinate synthase 2",TRUE
+"211560_s_at",0.980264692225439,0.907851397018311,-0.117080094646644,-5.9330091465076,-0.0386144163462596,"ALAS2","5'-aminolevulinate synthase 2",TRUE
+"214842_s_at",0.752913428584105,0.246092961163097,1.19142597660336,-5.2709829505538,1.18319815889295,"ALB","albumin",TRUE
+"214837_at",0.773107052530371,0.283958719999546,1.09808213935233,-5.36885893618778,0.640023791168479,"ALB","albumin",TRUE
+"211298_s_at",0.970394102491117,0.859058351143577,0.179652345161119,-5.92397575045745,0.206402481242748,"ALB","albumin",TRUE
+"1565228_s_at",0.983567332578112,0.920082140875075,-0.101480064795231,-5.93466884995202,-0.142833764301596,"ALB","albumin",TRUE
+"201952_at",0.868039927215454,0.501710431326103,0.682961675932444,-5.71501770755878,0.651675040910758,"ALCAM","activated leukocyte cell adhesion molecule",TRUE
+"201951_at",0.884749233889577,0.544294902652606,0.615809664311011,-5.75664758121496,0.906205528118164,"ALCAM","activated leukocyte cell adhesion molecule",TRUE
+"1569362_at",0.936992192746977,0.719137546545008,0.364232207221029,-5.87527296625883,0.249240060421214,"ALCAM","activated leukocyte cell adhesion molecule",TRUE
+"227592_at",0.821187434813103,0.382423292957271,-0.891151590640114,-5.56011160261773,-0.350443780821058,"ALDH16A1","aldehyde dehydrogenase 16 family member A1",TRUE
+"222416_at",0.636147339487472,0.107460119765603,-1.67768774396999,-4.65454379750485,-0.594682307482026,"ALDH18A1","aldehyde dehydrogenase 18 family member A1",TRUE
+"217791_s_at",0.775581183114088,0.292828018241463,-1.07754800455773,-5.38944035759117,-0.444701114872437,"ALDH18A1","aldehyde dehydrogenase 18 family member A1",TRUE
+"212224_at",0.829295110398113,0.40051882368857,0.857186208262046,-5.58800485255502,1.6230740076205,"ALDH1A1","aldehyde dehydrogenase 1 family member A1",TRUE
+"207015_s_at",0.448873991611994,0.0213995973225811,2.47598158206355,-3.327082882548,1.25043793257183,"ALDH1A2","aldehyde dehydrogenase 1 family member A2",TRUE
+"203180_at",0.153726668922469,0.00115323064069688,3.72946509272223,-0.782279073907955,5.85449430519524,"ALDH1A3","aldehyde dehydrogenase 1 family member A3",TRUE
+"1558649_at",0.399312926596283,0.0141444820489014,2.66339669540509,-2.97291282274767,1.57296584869967,"ALDH1A3","aldehyde dehydrogenase 1 family member A3",TRUE
+"209645_s_at",0.713330901550199,0.18801092435536,1.35839034746251,-5.07881097716414,0.590000438143393,"ALDH1B1","aldehyde dehydrogenase 1 family member B1",TRUE
+"209646_x_at",0.88113080359582,0.537590763856533,0.62618661007177,-5.75048493185936,0.216277162380425,"ALDH1B1","aldehyde dehydrogenase 1 family member B1",TRUE
+"215798_at",0.674680903837191,0.14104547783035,1.52645784545716,-4.86435847692979,0.716422276732588,"ALDH1L1","aldehyde dehydrogenase 1 family member L1",TRUE
+"205208_at",0.726480797733202,0.205427734229784,1.30457089628493,-5.14309352683849,1.1565501890346,"ALDH1L1","aldehyde dehydrogenase 1 family member L1",TRUE
+"1559766_at",0.747780646916362,0.239676416958656,1.208283998715,-5.25256264776989,0.799143137850287,"ALDH1L1-AS2","ALDH1L1 antisense RNA 2",TRUE
+"1556841_a_at",0.180091551279879,0.00164085030166926,3.58384411689891,-1.09300281721351,2.70175765652421,"ALDH1L2","aldehyde dehydrogenase 1 family member L2",TRUE
+"231202_at",0.508488499910913,0.0335314554211289,2.26639935068719,-3.70653950983408,2.83812580948544,"ALDH1L2","aldehyde dehydrogenase 1 family member L2",TRUE
+"1559393_at",0.595997098747707,0.0725425920700555,1.88550167499905,-4.34223560649003,1.33932398827601,"ALDH1L2","aldehyde dehydrogenase 1 family member L2",TRUE
+"201425_at",0.854184492233394,0.46463954551325,0.744092154403644,-5.67354894597595,0.900648010902508,"ALDH2","aldehyde dehydrogenase 2 family (mitochondrial)",TRUE
+"205623_at",0.238811487311851,0.00315225155336802,3.31159564138688,-1.66698579676241,3.42284959463773,"ALDH3A1","aldehyde dehydrogenase 3 family member A1",TRUE
+"210544_s_at",0.769258076576208,0.276470282269334,1.11578364553672,-5.35083954126595,0.52748415830437,"ALDH3A2","aldehyde dehydrogenase 3 family member A2",TRUE
+"202053_s_at",0.783598827774051,0.306187569393047,1.04744331237998,-5.41898572915551,0.477709241003332,"ALDH3A2","aldehyde dehydrogenase 3 family member A2",TRUE
+"202054_s_at",0.796277508155242,0.328501791933235,0.999166490899306,-5.46478945898425,0.550671056077,"ALDH3A2","aldehyde dehydrogenase 3 family member A2",TRUE
+"211004_s_at",0.429960090499345,0.0190542898816628,2.5290302797595,-3.22816166849461,1.19557531419403,"ALDH3B1","aldehyde dehydrogenase 3 family member B1",TRUE
+"205640_at",0.54775309185967,0.0480934020170699,2.09217163935712,-4.00667903958499,2.78734268711949,"ALDH3B1","aldehyde dehydrogenase 3 family member B1",TRUE
+"1565731_at",0.961212424803935,0.823728836957568,0.225406890847933,-5.91496690243012,0.113256022898513,"ALDH3B1","aldehyde dehydrogenase 3 family member B1",TRUE
+"204941_s_at",0.355028107426795,0.00955066039823787,-2.83703848663804,-2.63402865909464,-4.61259770166057,"ALDH3B2","aldehyde dehydrogenase 3 family member B2",TRUE
+"204942_s_at",0.406164654174876,0.0153830222988573,-2.62579250240019,-3.04499867308526,-3.97555866201741,"ALDH3B2","aldehyde dehydrogenase 3 family member B2",TRUE
+"203722_at",0.628431683645179,0.0996295534309358,-1.71860710799586,-4.59517563261069,-1.3414908980022,"ALDH4A1","aldehyde dehydrogenase 4 family member A1",TRUE
+"211552_s_at",0.793993897335353,0.325763113601467,-1.00496575658641,-5.45939062112716,-0.618786083710244,"ALDH4A1","aldehyde dehydrogenase 4 family member A1",TRUE
+"203608_at",0.419258213999957,0.017282484069403,-2.57331717227452,-3.14475633275061,-2.55332777719768,"ALDH5A1","aldehyde dehydrogenase 5 family member A1",TRUE
+"203609_s_at",0.808233282592165,0.350203210321665,0.954350365904108,-5.50555090087671,0.650430714826298,"ALDH5A1","aldehyde dehydrogenase 5 family member A1",TRUE
+"221589_s_at",0.422574093216884,0.0176686665346237,-2.56331370729639,-3.16365976407528,-1.42791778456762,"ALDH6A1","aldehyde dehydrogenase 6 family member A1",TRUE
+"204290_s_at",0.579111490485788,0.0621553275979555,-1.96434619071124,-4.21700402972436,-1.30058033692492,"ALDH6A1","aldehyde dehydrogenase 6 family member A1",TRUE
+"221588_x_at",0.603702127972549,0.0782683683374473,-1.84618550914499,-4.4033388692172,-1.04286074610714,"ALDH6A1","aldehyde dehydrogenase 6 family member A1",TRUE
+"221590_s_at",0.608471160331072,0.081207390158863,-1.82696834679446,-4.43287155615329,-1.11870515126253,"ALDH6A1","aldehyde dehydrogenase 6 family member A1",TRUE
+"204289_at",0.728385463227073,0.209049090751787,1.29383079730307,-5.15565880573501,1.13117294519999,"ALDH6A1","aldehyde dehydrogenase 6 family member A1",TRUE
+"208950_s_at",0.955645941042265,0.797025244491149,0.260314292958556,-5.90673215274723,0.325888560733754,"ALDH7A1","aldehyde dehydrogenase 7 family member A1",TRUE
+"213591_at",0.976371465776674,0.88719912224128,0.143491417541614,-5.92965992778946,0.121540811221691,"ALDH7A1","aldehyde dehydrogenase 7 family member A1",TRUE
+"208951_at",0.99164669139131,0.960472855543539,-0.0501237981581433,-5.93845985979226,-0.0369720842649262,"ALDH7A1","aldehyde dehydrogenase 7 family member A1",TRUE
+"220148_at",0.94943075115007,0.771320807370499,0.294230237807592,-5.89760547002556,0.18991481550312,"ALDH8A1","aldehyde dehydrogenase 8 family member A1",TRUE
+"201612_at",0.500677386446044,0.0319388968546234,-2.28947199590639,-3.66570631766442,-0.793255268870272,"ALDH9A1","aldehyde dehydrogenase 9 family member A1",TRUE
+"238996_x_at",0.774230543658252,0.287176778781552,-1.0905789644468,-5.37641952885483,-0.360905543707746,"ALDOA","aldolase, fructose-bisphosphate A",TRUE
+"200966_x_at",0.878907265409251,0.532458234489369,-0.634177959280652,-5.74567147011513,-0.167765099490001,"ALDOA","aldolase, fructose-bisphosphate A",TRUE
+"214687_x_at",0.884227283169589,0.543215550331657,-0.617475706885683,-5.75566484071417,-0.153538544174696,"ALDOA","aldolase, fructose-bisphosphate A",TRUE
+"211617_at",0.975398143273847,0.881147315605862,0.151249798858788,-5.92854731889643,0.116555892534075,"ALDOAP2","aldolase, fructose-bisphosphate A pseudogene 2",TRUE
+"204704_s_at",0.597654932724127,0.0737228376105141,1.87718126915866,-4.35524258834054,1.43650095468961,"ALDOB","aldolase, fructose-bisphosphate B",TRUE
+"214424_s_at",0.647382402854918,0.11817499728079,-1.62560223937321,-4.72853745199293,-0.908138747576474,"ALDOB","aldolase, fructose-bisphosphate B",TRUE
+"217238_s_at",0.721499527275875,0.197782371568589,1.32773794347945,-5.11569055488234,0.898547529939954,"ALDOB","aldolase, fructose-bisphosphate B",TRUE
+"214423_x_at",0.734730148360473,0.219677698930419,1.26311770534483,-5.19110293842121,0.312113234687248,"ALDOB","aldolase, fructose-bisphosphate B",TRUE
+"211357_s_at",0.792305111661886,0.323362656200068,1.0100767520126,-5.45460905047565,0.573692805735167,"ALDOB","aldolase, fructose-bisphosphate B",TRUE
+"204705_x_at",0.858574065957936,0.47433174643485,0.727843020365889,-5.68490148564534,0.320886711120026,"ALDOB","aldolase, fructose-bisphosphate B",TRUE
+"243901_at",0.875187315707138,0.522204169388838,0.65026964384283,-5.73580088620621,0.776943994031579,"ALDOB","aldolase, fructose-bisphosphate B",TRUE
+"216600_x_at",0.921980251030053,0.667138069248386,0.43588417691517,-5.84756521635345,0.104701567057671,"ALDOB","aldolase, fructose-bisphosphate B",TRUE
+"241280_at",0.96351240321323,0.833915856286682,0.212167726969285,-5.91778201677549,0.0753055768318243,"ALDOB","aldolase, fructose-bisphosphate B",TRUE
+"202022_at",0.750326501261927,0.243299601932759,1.19872381513319,-5.26303641677202,0.883508785281158,"ALDOC","aldolase, fructose-bisphosphate C",TRUE
+"223355_at",0.581367983493308,0.0638308551423928,-1.95087853532719,-4.23864498716834,-0.888873237126944,"ALG1","ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase",TRUE
+"1552304_at",0.821990323055816,0.385340354741537,0.885606621304849,-5.56473395025748,0.298178346807773,"ALG10","ALG10, alpha-1,2-glucosyltransferase",TRUE
+"1552306_at",0.957289701021675,0.806731244959766,-0.247590498081273,-5.90987002489964,-0.0886638965107682,"ALG10","ALG10, alpha-1,2-glucosyltransferase",TRUE
+"238475_at",0.693851377449481,0.163173781161342,-1.44241333484792,-4.97414657475216,-0.523481553640677,"ALG10B///ALG10","ALG10B, alpha-1,2-glucosyltransferase///ALG10, alpha-1,2-glucosyltransferase",TRUE
+"228941_at",0.867924303277286,0.501170565722143,-0.683832909029844,-5.71445049967706,-0.280216259089544,"ALG10B///ALG10","ALG10B, alpha-1,2-glucosyltransferase///ALG10, alpha-1,2-glucosyltransferase",TRUE
+"242900_at",0.941833562132083,0.738970549136766,0.337427295366628,-5.88437949004832,0.130253179356597,"ALG10B///ALG10","ALG10B, alpha-1,2-glucosyltransferase///ALG10, alpha-1,2-glucosyltransferase",TRUE
+"221513_s_at",0.844245372791972,0.440941220472021,-0.784696624583074,-5.64414425214721,-0.212032776967691,"ALG11///UTP14A///UTP14C","ALG11, alpha-1,2-mannosyltransferase///UTP14A small subunit processome component///UTP14, small subunit processome component homolog C (S. cerevisiae)",TRUE
+"203614_at",0.861659105448003,0.483547741932235,-0.712572164916046,-5.69535338353664,-0.267186464774072,"ALG11///UTP14C","ALG11, alpha-1,2-mannosyltransferase///UTP14, small subunit processome component homolog C (S. cerevisiae)",TRUE
+"218444_at",0.896345073598643,0.580518985668574,0.560863329949221,-5.78761974868605,0.4140456596087,"ALG12","ALG12, alpha-1,6-mannosyltransferase",TRUE
+"205583_s_at",0.865345395265289,0.495041839494665,-0.693761013702892,-5.70793812082417,-0.306965823941194,"ALG13","ALG13, UDP-N-acetylglucosaminyltransferase subunit",TRUE
+"219015_s_at",0.885929137203218,0.547928718033676,-0.610213509626842,-5.75992981426379,-0.251714273021548,"ALG13","ALG13, UDP-N-acetylglucosaminyltransferase subunit",TRUE
+"222808_at",0.912421110187259,0.633175461609989,-0.483942528338009,-5.82625242199346,-0.27449912069099,"ALG13","ALG13, UDP-N-acetylglucosaminyltransferase subunit",TRUE
+"205584_at",0.930558143410966,0.692789251413741,-0.400272092368966,-5.86194718343194,-0.161611286568336,"ALG13","ALG13, UDP-N-acetylglucosaminyltransferase subunit",TRUE
+"232435_at",0.951810226174863,0.778959960746933,0.284115669366588,-5.90044320898144,0.142281153273702,"ALG13","ALG13, UDP-N-acetylglucosaminyltransferase subunit",TRUE
+"1553954_at",0.76174779017913,0.260896005832545,-1.15375182921642,-5.31133107897337,-0.483925942001429,"ALG14","ALG14, UDP-N-acetylglucosaminyltransferase subunit",TRUE
+"228871_at",0.98453870130544,0.924734407280275,0.0955531878867449,-5.93523737209791,0.0562176112873187,"ALG14","ALG14, UDP-N-acetylglucosaminyltransferase subunit",TRUE
+"225621_at",0.812896635201594,0.361722977718786,-0.931325126880725,-5.52582716717463,-0.314657924996853,"ALG2","ALG2, alpha-1,3/1,6-mannosyltransferase",TRUE
+"228166_at",0.860714927752408,0.480585000364632,0.71746275326062,-5.69202904315362,0.305158827724466,"ALG2","ALG2, alpha-1,3/1,6-mannosyltransferase",TRUE
+"207396_s_at",0.945819521856653,0.755296051858357,0.315551364361987,-5.89130133754603,0.0887064893351148,"ALG3","ALG3, alpha-1,3- mannosyltransferase",TRUE
+"218203_at",0.670152406964446,0.135842677705684,-1.54777317644196,-4.8357251411988,-0.53722936589125,"ALG5","ALG5, dolichyl-phosphate beta-glucosyltransferase",TRUE
+"1560733_at",0.837368340567858,0.421187143794772,0.819575697111588,-5.61771199267486,0.334841275457669,"ALG5","ALG5, dolichyl-phosphate beta-glucosyltransferase",TRUE
+"222556_at",0.979588787486838,0.902793953847032,-0.12353922664954,-5.9322526850571,-0.0799736429089402,"ALG5","ALG5, dolichyl-phosphate beta-glucosyltransferase",TRUE
+"219649_at",0.948962238903406,0.769708611843286,-0.296368828683785,-5.89699286055562,-0.0893504823303903,"ALG6","ALG6, alpha-1,3-glucosyltransferase",TRUE
+"203545_at",0.943464796017993,0.746683062774707,-0.327072374947038,-5.88771314681598,-0.114534555071009,"ALG8","ALG8, alpha-1,3-glucosyltransferase",TRUE
+"228817_at",0.822010986888098,0.385860301389721,0.884621152108189,-5.56555265024082,0.408125699564764,"ALG9","ALG9, alpha-1,2-mannosyltransferase",TRUE
+"219374_s_at",0.832792886465252,0.409722175383302,0.840290067229332,-5.60150448329617,0.285084964153931,"ALG9","ALG9, alpha-1,2-mannosyltransferase",TRUE
+"208211_s_at",0.594972224548427,0.0715302847784528,1.89273302177845,-4.33089833028152,1.22458033746195,"ALK","anaplastic lymphoma receptor tyrosine kinase",TRUE
+"208212_s_at",0.760227035076299,0.258013526571406,1.16096091777087,-5.30369816351618,0.832311616414316,"ALK","anaplastic lymphoma receptor tyrosine kinase",TRUE
+"205621_at",0.767727587789514,0.269716580397362,-1.13205046428905,-5.33405566111019,-0.443933321974557,"ALKBH1","alkB homolog 1, histone H2A dioxygenase",TRUE
+"236721_at",0.868714861166452,0.50492221414928,-0.67778943089863,-5.7183708105592,-0.205990438808998,"ALKBH1","alkB homolog 1, histone H2A dioxygenase",TRUE
+"225625_at",0.806422472374043,0.347396019134154,-0.960038640806259,-5.50047187934214,-0.348743034334854,"ALKBH2","alkB homolog 2, alpha-ketoglutarate dependent dioxygenase",TRUE
+"226127_at",0.988173753615796,0.943658491518755,-0.0714781524259946,-5.93719532006337,-0.0784053505578122,"ALKBH3","alkB homolog 3, alpha-ketoglutaratedependent dioxygenase",TRUE
+"1557565_a_at",0.768852835478002,0.272528976212045,1.12524081122911,-5.3411079075162,0.558716162749731,"ALKBH3-AS1","ALKBH3 antisense RNA 1",TRUE
+"1557564_at",0.832792886465252,0.409800887525784,0.840146611364055,-5.6016180274752,0.507520769456955,"ALKBH3-AS1","ALKBH3 antisense RNA 1",TRUE
+"222228_s_at",0.914562242038395,0.640084842319912,-0.474075094318099,-5.83080631418315,-0.146460047199543,"ALKBH4","alkB homolog 4, lysine demethylase",TRUE
+"228034_x_at",0.834454640870101,0.412747903793019,0.834788101420921,-5.60584627116738,0.402835375412911,"ALKBH5","alkB homolog 5, RNA demethylase",TRUE
+"234302_s_at",0.94632739401154,0.757186361899563,0.313028700839316,-5.8920700108356,0.0989424500238894,"ALKBH5","alkB homolog 5, RNA demethylase",TRUE
+"1553101_a_at",0.947062793209778,0.759565698244137,0.309856361798291,-5.89302796889369,0.118326204426191,"ALKBH5","alkB homolog 5, RNA demethylase",TRUE
+"225969_at",0.379201731949567,0.0116656115800489,-2.74904034857684,-2.80696087203062,-0.939908236606913,"ALKBH6","alkB homolog 6",TRUE
+"223317_at",0.890717257002192,0.559453522134655,0.592593078338313,-5.77007552550042,0.505947294291745,"ALKBH7","alkB homolog 7",TRUE
+"227878_s_at",0.921729477898827,0.666352346757957,-0.436983868114823,-5.84710194708553,-0.148469905125085,"ALKBH7","alkB homolog 7",TRUE
+"227879_at",0.936143408699214,0.714812985590623,0.370112574613327,-5.87318330662937,0.197578049171601,"ALKBH7","alkB homolog 7",TRUE
+"223318_s_at",0.940044918888428,0.730954748350886,-0.348229447534108,-5.88079235626739,-0.109660363866476,"ALKBH7","alkB homolog 7",TRUE
+"235713_at",0.381135657631489,0.0119994370719797,2.73655560134377,-2.8313014615923,0.723468313871852,"ALKBH8","alkB homolog 8, tRNA methyltransferase",TRUE
+"235610_at",0.579625094592471,0.0624239581805498,1.96216555532418,-4.220514939312,0.797041706657808,"ALKBH8","alkB homolog 8, tRNA methyltransferase",TRUE
+"220365_at",0.805168768064335,0.344419621978068,-0.966104024472928,-5.49502574129768,-0.622255424742145,"ALLC","allantoicase",TRUE
+"214220_s_at",0.54613142770476,0.0473663508034014,2.09965375672059,-3.99409992007909,0.79730898701062,"ALMS1","ALMS1, centrosome and basal body associated protein",TRUE
+"214221_at",0.728671251879936,0.210154554224464,1.2905809813682,-5.15944351731129,0.526769742306543,"ALMS1","ALMS1, centrosome and basal body associated protein",TRUE
+"214707_x_at",0.993294448465239,0.96862332160624,0.0397818690322182,-5.93891268544709,0.013063064264287,"ALMS1","ALMS1, centrosome and basal body associated protein",TRUE
+"1556911_at",0.78515014907967,0.310447107377522,1.03804131983367,-5.42805892534672,0.626131369159681,"ALMS1-IT1","ALMS1 intronic transcript 1",TRUE
+"1552576_at",0.772392316223901,0.282661506489184,1.10112409462032,-5.3657805659947,0.586085600233979,"ALMS1P1","ALMS1, centrosome and basal body associated protein pseudogene 1",TRUE
+"207206_s_at",0.478834284119248,0.0268388038548508,2.37120969456598,-3.51913056974244,1.92440768943358,"ALOX12","arachidonate 12-lipoxygenase, 12S type",TRUE
+"229833_at",0.813631136157676,0.364380302162235,0.926083935394026,-5.53037904663995,0.469232272844017,"ALOX12-AS1","ALOX12 antisense RNA 1",TRUE
+"236433_at",0.860085676417428,0.479271819118354,0.719636029387117,-5.69054483219674,0.689131075917405,"ALOX12-AS1","ALOX12 antisense RNA 1",TRUE
+"207381_at",0.957486345563554,0.808193778651267,-0.245676901635775,-5.9103284267418,-0.136929991610201,"ALOX12B","arachidonate 12-lipoxygenase, 12R type",TRUE
+"214340_at",0.397229407433966,0.0137789420512594,2.67508888839145,-2.95040028068381,1.54413077836361,"ALOX12P2","arachidonate 12-lipoxygenase pseudogene 2",TRUE
+"207328_at",0.660174819354133,0.128171114905242,-1.58046718368125,-4.79119874118416,-2.12071321364077,"ALOX15","arachidonate 15-lipoxygenase",TRUE
+"206714_at",0.954054753819891,0.789002115228126,0.270865137318553,-5.90401171491099,0.317284828311504,"ALOX15B","arachidonate 15-lipoxygenase, type B",TRUE
+"1555416_a_at",0.96617985047235,0.842409870175901,-0.201158491028119,-5.91999379482077,-0.29288278743201,"ALOX15B","arachidonate 15-lipoxygenase, type B",TRUE
+"204446_s_at",0.153432062055215,0.0011365337930016,3.73547070311049,-0.769421926466256,4.34231753078106,"ALOX5","arachidonate 5-lipoxygenase",TRUE
+"204445_s_at",0.316507537502531,0.00684825636699578,2.98154267725675,-2.34522980076369,2.09383662143409,"ALOX5","arachidonate 5-lipoxygenase",TRUE
+"214366_s_at",0.330171916405281,0.0079367942282562,2.91771658326838,-2.47348911533358,2.48163375631658,"ALOX5","arachidonate 5-lipoxygenase",TRUE
+"213952_s_at",0.7580782491858,0.254730875712843,1.16924390987189,-5.29487675344965,0.404669791164294,"ALOX5","arachidonate 5-lipoxygenase",TRUE
+"204174_at",0.6577569288805,0.126461668587392,1.58797273191003,-4.78087392933812,0.887044146475811,"ALOX5AP","arachidonate 5-lipoxygenase activating protein",TRUE
+"222383_s_at",0.792610942614642,0.324136428834365,-1.00842637899738,-5.45615545279691,-0.96429908258132,"ALOXE3","arachidonate lipoxygenase 3",TRUE
+"207708_at",0.85763244782852,0.47318409549511,0.729756788449853,-5.68357678451477,0.401473549558066,"ALOXE3","arachidonate lipoxygenase 3",TRUE
+"211618_s_at",0.182644973816866,0.00172448908601835,3.56324503020488,-1.13677779656065,1.49977252676608,"ALPI","alkaline phosphatase, intestinal",TRUE
+"207140_at",0.781367715385271,0.303029179067725,1.05447474087954,-5.41215214114763,0.233536453854634,"ALPI","alkaline phosphatase, intestinal",TRUE
+"207133_x_at",0.640067422642767,0.110798667815874,-1.66100665016645,-4.67843507803761,-0.928213604208477,"ALPK1","alpha kinase 1",TRUE
+"243352_at",0.663309898243682,0.131303210401305,1.56692837878406,-4.80972615194247,0.770518453392962,"ALPK1","alpha kinase 1",TRUE
+"227438_at",0.726945310232634,0.207107948742455,1.29956966675191,-5.1489556285755,1.15015695837933,"ALPK1","alpha kinase 1",TRUE
+"243222_at",0.935094665155941,0.711441054117951,0.374706824705233,-5.87152770384671,0.264820167741425,"ALPK1","alpha kinase 1",TRUE
+"228367_at",0.843816788557882,0.439578977700447,0.787070516443427,-5.64237954543694,0.344170998412899,"ALPK2","alpha kinase 2",TRUE
+"236987_at",0.947778780715578,0.761881403560622,-0.306771974340679,-5.8939500981734,-0.190028425304255,"ALPK2","alpha kinase 2",TRUE
+"214846_s_at",0.300116716920836,0.00562471633922242,3.06611236319281,-2.17370773514618,2.20537045065496,"ALPK3","alpha kinase 3",TRUE
+"228342_s_at",0.739340500562926,0.22659627690441,1.2437334373515,-5.21309786860923,1.05243269378974,"ALPK3","alpha kinase 3",TRUE
+"215783_s_at",0.497885178357455,0.0309615128289772,-2.30415931572499,-3.63958702282648,-0.910631851235466,"ALPL","alkaline phosphatase, liver/bone/kidney",TRUE
+"1557924_s_at",0.821424121108148,0.383584503752748,-0.88894096998409,-5.56195760393545,-0.577334730659754,"ALPL","alkaline phosphatase, liver/bone/kidney",TRUE
+"204664_at",0.130547951137661,0.000796504947457492,3.88152797228733,-0.455906740625786,5.95701166438732,"ALPP","alkaline phosphatase, placental",TRUE
+"216377_x_at",0.0883065246138892,0.000336563218397646,4.23366804349016,0.303947092089709,2.1415265525586,"ALPPL2","alkaline phosphatase, placental like 2",TRUE
+"210431_at",0.860085676417428,0.479507516753171,0.719245701371245,-5.69081171628953,0.445755558914793,"ALPPL2","alkaline phosphatase, placental like 2",TRUE
+"211619_s_at",0.0723378272955723,0.000224416188634336,4.39898204756311,0.661105620586453,3.27797235501331,"ALPPL2///ALPP","alkaline phosphatase, placental like 2///alkaline phosphatase, placental",TRUE
+"1560743_a_at",0.746535697909741,0.238350295476927,1.21181032763026,-5.24868111430362,0.990083872390932,"ALS2","ALS2, alsin Rho guanine nucleotide exchange factor",TRUE
+"232184_at",0.762225611287473,0.261659122053124,-1.15185314256544,-5.31333444291774,-0.566869421773488,"ALS2","ALS2, alsin Rho guanine nucleotide exchange factor",TRUE
+"226291_at",0.796595529644756,0.329419751719578,0.997230177175384,-5.46658575939537,0.281189097930655,"ALS2","ALS2, alsin Rho guanine nucleotide exchange factor",TRUE
+"1555284_at",0.847150509759315,0.445848302118414,-0.776182362583258,-5.65043226308654,-0.310430342293184,"ALS2","ALS2, alsin Rho guanine nucleotide exchange factor",TRUE
+"1560742_at",0.933993359946081,0.707456015818441,-0.38014705073317,-5.8695411879677,-0.33493909611021,"ALS2","ALS2, alsin Rho guanine nucleotide exchange factor",TRUE
+"243276_at",0.196858188611682,0.00214708646432781,3.47219415877319,-1.32964929853409,3.01025227241685,"ALS2CL","ALS2 C-terminal like",TRUE
+"222333_at",0.237644535895285,0.00310488984704237,3.31795629947384,-1.65370342917399,0.988123170581881,"ALS2CL","ALS2 C-terminal like",TRUE
+"229887_at",0.535243600695458,0.0427684303156047,2.14951501324767,-3.9095433097988,0.723246909651504,"ALS2CL","ALS2 C-terminal like",TRUE
+"1554831_x_at",0.468732760220321,0.0247968351176631,2.40801808324299,-3.45217861451798,1.20581134504018,"ALS2CR11","amyotrophic lateral sclerosis 2 chromosome region candidate 11",TRUE
+"1553261_x_at",0.52410084490644,0.0390139997945901,2.19395954788192,-3.83312709453967,1.7613812854803,"ALS2CR11","amyotrophic lateral sclerosis 2 chromosome region candidate 11",TRUE
+"1553260_s_at",0.62952950109137,0.100315532565602,1.714915227753,-4.60057606409633,1.31786163534736,"ALS2CR11","amyotrophic lateral sclerosis 2 chromosome region candidate 11",TRUE
+"1558428_at",0.698391916012681,0.1693685562382,1.42054794153991,-5.00188111059068,1.43571312595224,"ALS2CR11","amyotrophic lateral sclerosis 2 chromosome region candidate 11",TRUE
+"1556757_a_at",0.763650705722297,0.263640129468321,-1.14694326951728,-5.31850155260916,-0.769504822377392,"ALS2CR11","amyotrophic lateral sclerosis 2 chromosome region candidate 11",TRUE
+"1563673_a_at",0.978255630670068,0.89478890417931,-0.133774033228877,-5.93097100345857,-0.101886094521657,"ALS2CR11","amyotrophic lateral sclerosis 2 chromosome region candidate 11",TRUE
+"242661_x_at",0.81304218438764,0.362289965162973,-0.930204668599746,-5.52680225023324,-0.521770584497303,"ALS2CR12","amyotrophic lateral sclerosis 2 chromosome region candidate 12",TRUE
+"239458_at",0.855405088766616,0.468026843132832,-0.738390708326449,-5.67755937267272,-0.609219570833964,"ALS2CR12","amyotrophic lateral sclerosis 2 chromosome region candidate 12",TRUE
+"206837_at",0.0177522424392202,1.16887193015441e-05,5.61719318420528,3.24309945876361,3.07038162993461,"ALX1","ALX homeobox 1",TRUE
+"207690_at",0.725181883744124,0.203748169040276,1.30960204698874,-5.13717711760532,0.898836015823999,"ALX3","ALX homeobox 3",TRUE
+"208330_at",0.837839105061376,0.422487795909088,0.81724826771045,-5.61950936700437,0.548077549667669,"ALX4","ALX homeobox 4",TRUE
+"226320_at",0.704136697708699,0.175973079234154,-1.39793114883895,-5.03020236463858,-0.707797656586573,"ALYREF","Aly/REF export factor",TRUE
+"226319_s_at",0.735125012228568,0.220140865573266,-1.26180553664437,-5.19260102922196,-0.594414462557628,"ALYREF","Aly/REF export factor",TRUE
+"217113_at",0.538039282264231,0.0437460813289591,2.13852184960891,-3.92829377019193,1.56090957505654,"AMACR","alpha-methylacyl-CoA racemase",TRUE
+"236365_at",0.741638713813265,0.2321156226936,1.22859065658872,-5.23007642066299,0.564570247619102,"AMACR","alpha-methylacyl-CoA racemase",TRUE
+"217111_at",0.773617493187087,0.284954416009049,1.09575405463421,-5.37120977318054,0.628024115285091,"AMACR","alpha-methylacyl-CoA racemase",TRUE
+"221114_at",0.816166006830229,0.367114231476467,0.920718232822182,-5.53501456743907,0.697862429112287,"AMBN","ameloblastin",TRUE
+"214425_at",0.624331975868069,0.0957323361076977,1.74000286315457,-4.56370798795514,0.702317055753799,"AMBP","alpha-1-microglobulin/bikunin precursor",TRUE
+"205477_s_at",0.819018525257656,0.374939589341678,-0.905505313119078,-5.548022222366,-1.13079222754254,"AMBP","alpha-1-microglobulin/bikunin precursor",TRUE
+"52731_at",0.402463840838386,0.0147970040895485,-2.64321540281555,-3.01166057628112,-0.771028987736752,"AMBRA1","autophagy and beclin 1 regulator 1",TRUE
+"234237_s_at",0.673870607802125,0.140480410298714,-1.52874124443849,-4.86130621384845,-0.498257462807527,"AMBRA1","autophagy and beclin 1 regulator 1",TRUE
+"222189_at",0.728385463227073,0.209173112685777,1.29346553905298,-5.15608458612159,0.79258802919552,"AMBRA1","autophagy and beclin 1 regulator 1",TRUE
+"219141_s_at",0.769258076576208,0.276025626266695,-1.11684565539355,-5.34975033433552,-0.319475042386481,"AMBRA1","autophagy and beclin 1 regulator 1",TRUE
+"234236_at",0.784925710185113,0.310262609150113,1.03844666445004,-5.42766927505031,0.857401085231076,"AMBRA1","autophagy and beclin 1 regulator 1",TRUE
+"201196_s_at",0.937271400689562,0.721828721012566,0.360579461520699,-5.87655437649492,0.151392995681547,"AMD1","adenosylmethionine decarboxylase 1",TRUE
+"201197_at",0.982243328340126,0.914654413106267,-0.108399586437506,-5.93396188001294,-0.0423156878181494,"AMD1","adenosylmethionine decarboxylase 1",TRUE
+"229596_at",0.971040109976404,0.861253072592574,0.176823932554599,-5.9244660867691,0.190379893176652,"AMDHD1","amidohydrolase domain containing 1",TRUE
+"208410_x_at",0.643688366500038,0.114349958058235,1.64372172894219,-4.70299908060526,0.551039056631983,"AMELX","amelogenin, X-linked",TRUE
+"208220_x_at",0.993863709454116,0.970981271399243,-0.0367908037507614,-5.93902423150439,-0.0306381699705849,"AMELY","amelogenin, Y-linked",TRUE
+"1552882_a_at",0.887083096014278,0.551384561555198,0.604909599505779,-5.76301395763197,0.334625474122042,"AMER1","APC membrane recruitment protein 1",TRUE
+"1553720_a_at",0.912722788750542,0.63428690096024,-0.482351990939282,-5.826992668493,-0.314222156767455,"AMER2","APC membrane recruitment protein 2",TRUE
+"230496_at",0.915939421175188,0.645103301078099,0.466938005066384,-5.83404291722701,0.352973782265501,"AMER2","APC membrane recruitment protein 2",TRUE
+"235465_at",0.998347572104896,0.993029693920503,-0.00883519755814272,-5.93964546032397,-0.00781493125148014,"AMER2","APC membrane recruitment protein 2",TRUE
+"236638_at",0.772420279152863,0.282775753224028,1.10085578148821,-5.36605239551107,0.474267052425569,"AMER3","APC membrane recruitment protein 3",TRUE
+"244709_at",0.900750978800947,0.596299882465401,0.537470691052743,-5.79995429659233,0.245937515314026,"AMER3","APC membrane recruitment protein 3",TRUE
+"1553350_at",0.942324052902057,0.740946936656167,-0.334770230534318,-5.88524470762467,-0.221498146738167,"AMER3","APC membrane recruitment protein 3",TRUE
+"202204_s_at",0.657183268009571,0.126111876505833,-1.58951892942803,-4.77874219971658,-0.74888486138746,"AMFR","autocrine motility factor receptor",TRUE
+"202203_s_at",0.891918115867831,0.561979868412073,0.588755866066036,-5.77224687345274,0.54696272600053,"AMFR","autocrine motility factor receptor",TRUE
+"206892_at",0.919346894795314,0.656179117009462,0.451272401178751,-5.84097846618772,0.188997284749302,"AMHR2","anti-Mullerian hormone receptor type 2",TRUE
+"226718_at",0.782930758690314,0.305453973728817,-1.04907189071296,-5.4174066287314,-0.41642084534173,"AMIGO1","adhesion molecule with Ig like domain 1",TRUE
+"222108_at",0.519956259865057,0.0375983345403375,2.21173097187032,-3.80230235901769,2.75581128462828,"AMIGO2","adhesion molecule with Ig like domain 2",TRUE
+"222710_at",0.638134354959023,0.109462511231228,-1.66763111819435,-4.66896898425749,-0.708659832226179,"AMIGO3///GMPPB","adhesion molecule with Ig like domain 3///GDP-mannose pyrophosphorylase B",TRUE
+"219920_s_at",0.740476003158683,0.229716215968436,-1.2351396112278,-5.22275552617069,-0.585722032961106,"AMIGO3///GMPPB","adhesion molecule with Ig like domain 3///GDP-mannose pyrophosphorylase B",TRUE
+"229717_at",0.818593126679085,0.371876704730464,-0.911434415697786,-5.54297637727122,-0.384359256596394,"AMIGO3///GMPPB","adhesion molecule with Ig like domain 3///GDP-mannose pyrophosphorylase B",TRUE
+"226421_at",0.812302873476553,0.357527964274479,-0.939651975620528,-5.51854690895724,-0.477180593392413,"AMMECR1","Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1",TRUE
+"236760_at",0.831487912516861,0.406140213839512,-0.84683697671773,-5.59630339935953,-0.46119556704851,"AMMECR1","Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1",TRUE
+"1553219_a_at",0.973071267819624,0.870128930717699,-0.165400102501771,-5.92636757789975,-0.0728569784708402,"AMMECR1","Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1",TRUE
+"204976_s_at",0.975398143273847,0.88117078713005,-0.151219690445977,-5.92855174963529,-0.0845574001588254,"AMMECR1","Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1",TRUE
+"223297_at",0.42796179417767,0.0185080316184382,-2.5422585765941,-3.20332590036277,-0.703980142611746,"AMMECR1L","AMMECR1 like",TRUE
+"1563792_at",0.56861088242915,0.0584898808782033,1.99496568763053,-4.16742697873236,0.906180287311597,"AMN","amnion associated transmembrane protein",TRUE
+"223587_s_at",0.801086839730802,0.337285924830755,-0.980788433961468,-5.48171092989705,-0.60639427335052,"AMN","amnion associated transmembrane protein",TRUE
+"220989_s_at",0.986421906591669,0.936521544055465,-0.0805518385708056,-5.93652361765031,-0.035687046105962,"AMN","amnion associated transmembrane protein",TRUE
+"226258_at",0.552420073963858,0.0497535300398637,-2.07546054341582,-4.03466952145085,-1.52392972500921,"AMN1","antagonist of mitotic exit network 1 homolog",TRUE
+"209521_s_at",0.950031925101785,0.773127032016073,-0.291835928021385,-5.89828611091315,-0.152100238293526,"AMOT","angiomotin",TRUE
+"235277_at",0.322131160460075,0.00723957531187784,2.95754620226573,-2.39357574149722,1.86869526122139,"AMOTL1","angiomotin like 1",TRUE
+"225450_at",0.366473876333673,0.0108182686127581,2.78231821405611,-2.74184184834469,1.8487320546018,"AMOTL1","angiomotin like 1",TRUE
+"225459_at",0.428002059292618,0.018623080001045,2.53944249904028,-3.20861855650534,2.35455741380714,"AMOTL1","angiomotin like 1",TRUE
+"228840_at",0.433660982257499,0.0196144409157097,2.51582828803607,-3.25288162861909,1.93897417015856,"AMOTL1","angiomotin like 1",TRUE
+"203002_at",0.748184017928985,0.24060772454819,1.20581631006568,-5.25527306868435,0.719044202115192,"AMOTL2","angiomotin like 2",TRUE
+"206121_at",0.470885186348082,0.0255176242081922,-2.3947156934353,-3.47644081463727,-1.77076515649288,"AMPD1","adenosine monophosphate deaminase 1",TRUE
+"212360_at",0.942303845415102,0.740721773915289,-0.335072816018071,-5.88514651838248,-0.220575212020753,"AMPD2","adenosine monophosphate deaminase 2",TRUE
+"207992_s_at",0.487765518929235,0.0288933585506463,2.33669454329792,-3.58138387293999,1.04065298800257,"AMPD3","adenosine monophosphate deaminase 3",TRUE
+"205257_s_at",0.647518308302168,0.118619317263819,-1.62352949049559,-4.73144498066633,-1.18466247969471,"AMPH","amphiphysin",TRUE
+"204294_at",0.831957210365167,0.408193831293056,0.843079013150572,-5.59929345807549,0.39446454465525,"AMT","aminomethyltransferase",TRUE
+"1562261_at",0.73223722457785,0.216470219483221,1.27226337503741,-5.18062443419526,0.98386505185484,"AMZ1","archaelysin family metallopeptidase 1",TRUE
+"1561179_s_at",0.977063818674184,0.890508739951264,0.139252349293448,-5.93024314512997,0.0401661306995518,"AMZ1","archaelysin family metallopeptidase 1",TRUE
+"218167_at",0.816966928109267,0.369194974291352,-0.916652311927605,-5.53851065923825,-0.363635977590995,"AMZ2","archaelysin family metallopeptidase 2",TRUE
+"223443_s_at",0.888972420461865,0.556425436610669,-0.597204236135853,-5.76744819296224,-0.266296943713684,"AMZ2P1","archaelysin family metallopeptidase 2 pseudogene 1",TRUE
+"241959_at",0.901788521024914,0.599315721929076,-0.533034913934012,-5.80223559910595,-0.212545019953856,"ANAPC10","anaphase promoting complex subunit 10",TRUE
+"207845_s_at",0.974982245454858,0.877846855612172,-0.155484947366845,-5.92791530786509,-0.0472113287359903,"ANAPC10","anaphase promoting complex subunit 10",TRUE
+"226414_s_at",0.446963972064621,0.0211685331600719,-2.48096087176214,-3.3178446520962,-0.867289361180866,"ANAPC11","anaphase promoting complex subunit 11",TRUE
+"224010_at",0.929126743655924,0.688397519524858,-0.406330710279806,-5.85958548019666,-0.159646476921834,"ANAPC11","anaphase promoting complex subunit 11",TRUE
+"209001_s_at",0.615821255316333,0.0864189365277877,-1.79432712117555,-4.48252378411148,-0.563604034913984,"ANAPC13","anaphase promoting complex subunit 13",TRUE
+"215282_at",0.774230543658252,0.287807684037328,-1.08911508070838,-5.37788923247298,-1.12881469676637,"ANAPC13","anaphase promoting complex subunit 13",TRUE
+"204218_at",0.94118897722809,0.736569168531923,0.340659061629021,-5.88331801499328,0.127430034451987,"ANAPC15","anaphase promoting complex subunit 15",TRUE
+"224664_at",0.775631536783493,0.292945427244246,1.07727920025729,-5.38970748205194,0.367210579071777,"ANAPC16","anaphase promoting complex subunit 16",TRUE
+"229145_at",0.779813064835198,0.300990707910194,1.05904061324479,-5.40769276189981,0.463986421765794,"ANAPC16","anaphase promoting complex subunit 16",TRUE
+"224665_at",0.782198428867091,0.303995142478222,1.05231874762812,-5.41425183728013,0.361106096770415,"ANAPC16","anaphase promoting complex subunit 16",TRUE
+"224667_x_at",0.860832413449736,0.4808380778556,0.717044315313669,-5.69231431965159,0.247499777890742,"ANAPC16","anaphase promoting complex subunit 16",TRUE
+"218555_at",0.331069603215022,0.00804706111921988,-2.9117260877148,-2.48547165913009,-0.934975088116044,"ANAPC2","anaphase promoting complex subunit 2",TRUE
+"232524_x_at",0.763681732807712,0.263675133595576,1.1468567578272,-5.31859242272987,0.370098920149225,"ANAPC4","anaphase promoting complex subunit 4",TRUE
+"226917_s_at",0.786455312223125,0.312269608926181,1.03404636113728,-5.43189187307761,0.299202591473012,"ANAPC4","anaphase promoting complex subunit 4",TRUE
+"200098_s_at",0.727074488271062,0.20729199449669,-1.29902376194868,-5.14959434553949,-0.420398332170336,"ANAPC5","anaphase promoting complex subunit 5",TRUE
+"208722_s_at",0.7768734672127,0.294418229584167,-1.07391380958328,-5.39304680077099,-0.364951077174272,"ANAPC5","anaphase promoting complex subunit 5",TRUE
+"208721_s_at",0.846758911329672,0.4452550288199,-0.777208700230329,-5.64967771411029,-0.3218719498133,"ANAPC5","anaphase promoting complex subunit 5",TRUE
+"211036_x_at",0.85334340854827,0.461609230017808,-0.749213714265603,-5.66992148911578,-0.228755905827338,"ANAPC5","anaphase promoting complex subunit 5",TRUE
+"235926_at",0.854350135157525,0.46523817323849,0.743082762920669,-5.67426108776441,0.40787082961995,"ANAPC5","anaphase promoting complex subunit 5",TRUE
+"239651_at",0.971735822349954,0.86485179902901,-0.172189312566912,-5.92525277769862,-0.0941287737056271,"ANAPC5","anaphase promoting complex subunit 5",TRUE
+"225521_at",0.823518986434235,0.390560438581704,-0.875751879250819,-5.57288294069277,-0.371233617276198,"ANAPC7","anaphase promoting complex subunit 7",TRUE
+"225554_s_at",0.849935057946582,0.45200956157623,-0.765572348054347,-5.65817743208344,-0.240675350105246,"ANAPC7","anaphase promoting complex subunit 7",TRUE
+"205141_at",0.961212424803935,0.823445057034752,0.225776273638953,-5.91488592748635,0.198910349088788,"ANG","angiogenin",TRUE
+"213099_at",0.683019114815084,0.151812273343493,-1.4843195748556,-4.92003010605407,-0.599468659502262,"ANGEL1","angel homolog 1",TRUE
+"36865_at",0.736462193466674,0.221987193588404,-1.25659575312206,-5.19853582894432,-0.426360272627756,"ANGEL1","angel homolog 1",TRUE
+"244685_at",0.831875452294783,0.407069227865993,0.845135454990439,-5.59765876835803,0.501813161439112,"ANGEL1","angel homolog 1",TRUE
+"221825_at",0.710824498521146,0.184091792714567,-1.37103757279024,-5.06338949718991,-0.616921752234491,"ANGEL2","angel homolog 2",TRUE
+"217630_at",0.766825795427257,0.267965852364965,-1.13631582573414,-5.32961921481951,-0.442931763269896,"ANGEL2","angel homolog 2",TRUE
+"221826_at",0.941311073534434,0.737364902507243,-0.339587758599159,-5.88367099366318,-0.111609897118065,"ANGEL2","angel homolog 2",TRUE
+"1552939_at",0.789860910391852,0.318843027794236,1.01977207167526,-5.44547831048876,0.924709423762052,"ANGPT1","angiopoietin 1",TRUE
+"205609_at",0.931370027472813,0.696481390192382,0.395190377866526,-5.86390113958293,0.412195166030166,"ANGPT1","angiopoietin 1",TRUE
+"205608_s_at",0.981140604770329,0.910914785395147,0.11317017461709,-5.93344735000441,0.0512460685812046,"ANGPT1","angiopoietin 1",TRUE
+"237261_at",0.85334340854827,0.46151865239966,0.749367108307399,-5.66981248087123,0.334496798477257,"ANGPT2","angiopoietin 2",TRUE
+"236034_at",0.954804534580187,0.794433981034093,0.263718584513156,-5.90586611765667,0.155301122403535,"ANGPT2","angiopoietin 2",TRUE
+"205572_at",0.979588787486838,0.902263006404918,-0.124217635578694,-5.93217087976936,-0.0875625431444558,"ANGPT2","angiopoietin 2",TRUE
+"211148_s_at",0.990810941805126,0.956753503057745,-0.0548449871225122,-5.93821851438642,-0.0318721733778018,"ANGPT2","angiopoietin 2",TRUE
+"221134_at",0.817857130700434,0.370672148125409,0.913775045571776,-5.54097606520438,0.769851655672997,"ANGPT4","angiopoietin 4",TRUE
+"239183_at",0.7717895132349,0.281255220781019,1.10443326997513,-5.3624231825528,0.792519397603847,"ANGPTL1","angiopoietin like 1",TRUE
+"224339_s_at",0.784708646973769,0.308741576073645,-1.04179489178382,-5.42444544787027,-0.491383839921236,"ANGPTL1","angiopoietin like 1",TRUE
+"231773_at",0.851733415458562,0.456083192800772,0.758605293326263,-5.66320849699868,0.630122977997213,"ANGPTL1","angiopoietin like 1",TRUE
+"219514_at",0.697713925841949,0.168643413834381,1.42307391906525,-4.99869483534404,1.15829768941812,"ANGPTL2","angiopoietin like 2",TRUE
+"213004_at",0.937113154905832,0.720920383304468,0.361811791931752,-5.87612349136178,0.278525726686699,"ANGPTL2","angiopoietin like 2",TRUE
+"213001_at",0.986482025143628,0.937281813506411,0.0795849402469288,-5.93659900925149,0.0549275666120685,"ANGPTL2","angiopoietin like 2",TRUE
+"231684_at",0.935429186649424,0.712876596618593,-0.372749902439425,-5.87223537220781,-0.301292501804288,"ANGPTL3","angiopoietin like 3",TRUE
+"243799_x_at",0.956734254923335,0.803857820725443,-0.251352881524487,-5.90895843720463,-0.220421128634346,"ANGPTL3","angiopoietin like 3",TRUE
+"219803_at",0.968269082055813,0.850791168362512,0.19032022851877,-5.92205656626091,0.131288037120308,"ANGPTL3","angiopoietin like 3",TRUE
+"221009_s_at",0.962351204352784,0.828554903421999,-0.219129892975861,-5.91632275253523,-0.211826200220929,"ANGPTL4","angiopoietin like 4",TRUE
+"223333_s_at",0.998384473324293,0.993380123058344,0.00839100062002223,-5.93964918723223,0.00870149128159259,"ANGPTL4","angiopoietin like 4",TRUE
+"223967_at",0.969946179106301,0.857815888752523,-0.181254212583878,-5.92369460865887,-0.102832483067719,"ANGPTL6","angiopoietin like 6",TRUE
+"206423_at",0.62282585384278,0.0932971545245245,-1.75375319676135,-4.54333251970208,-1.13674558428263,"ANGPTL7","angiopoietin like 7",TRUE
+"220437_at",0.804627304763424,0.34351368171537,0.967957262963264,-5.49335545958616,0.407506993387068,"ANGPTL8","angiopoietin like 8",TRUE
+"1556959_at",0.639705117673934,0.110165489616703,1.66413739830338,-4.67396494005432,1.35859438365724,"ANHX","anomalous homeobox",TRUE
+"1556960_a_at",0.801086839730802,0.337090232128878,0.981194246033076,-5.48134036775866,0.410230847097022,"ANHX","anomalous homeobox",TRUE
+"207087_x_at",0.818854105808043,0.372759977542048,-0.909721278881852,-5.54443743090761,-1.12071638618696,"ANK1","ankyrin 1",TRUE
+"240363_at",0.83633038614858,0.417935297685183,-0.825414464795738,-5.61318188998962,-0.313773373582811,"ANK1","ankyrin 1",TRUE
+"205389_s_at",0.843816788557882,0.439817070690164,0.786655282299194,-5.64268858503625,0.880522442993186,"ANK1","ankyrin 1",TRUE
+"208352_x_at",0.895690630367785,0.5754652311686,0.568421443341276,-5.78352551313547,0.687828034882926,"ANK1","ankyrin 1",TRUE
+"208353_x_at",0.90574880691281,0.612059952611859,-0.5144079259706,-5.81161441757964,-0.520146852487759,"ANK1","ankyrin 1",TRUE
+"205391_x_at",0.957440336789825,0.808000624048866,0.245929573518651,-5.91026810183587,0.32500012005594,"ANK1","ankyrin 1",TRUE
+"205390_s_at",0.957555097864723,0.808416835364266,-0.245385134157149,-5.91039800894517,-0.30190373307985,"ANK1","ankyrin 1",TRUE
+"202921_s_at",0.242157727349446,0.0032464858554576,-3.2992119141082,-1.6928255654332,-1.31352840267399,"ANK2","ankyrin 2, neuronal",TRUE
+"202920_at",0.918041148686074,0.65183976001357,-0.457396102724063,-5.83829496081228,-0.419285599462104,"ANK2","ankyrin 2, neuronal",TRUE
+"216195_at",0.933400538871064,0.705430655270681,0.382916471274957,-5.86851907921861,0.260709288187596,"ANK2","ankyrin 2, neuronal",TRUE
+"232606_at",0.991207614339657,0.958629652145448,-0.0524633299264214,-5.93834297662412,-0.0296870422213518,"ANK2","ankyrin 2, neuronal",TRUE
+"238786_at",0.713005775571409,0.187608913925433,-1.35967802049491,-5.07724629501523,-0.827700072493045,"ANK3","ankyrin 3, node of Ranvier (ankyrin G)",TRUE
+"207950_s_at",0.773234064853267,0.284447730858662,-1.09693802307212,-5.37001478854464,-0.608503873265581,"ANK3","ankyrin 3, node of Ranvier (ankyrin G)",TRUE
+"206385_s_at",0.7994347047598,0.334689398720291,-0.986186141432964,-5.47677066475324,-0.983622605493583,"ANK3","ankyrin 3, node of Ranvier (ankyrin G)",TRUE
+"209442_x_at",0.857316604145187,0.472534212691205,-0.730841712566147,-5.68282433781938,-0.462496890677246,"ANK3","ankyrin 3, node of Ranvier (ankyrin G)",TRUE
+"239726_at",0.955959857580254,0.801082995788834,-0.254989683904906,-5.90806428910317,-0.150727293088018,"ANK3","ankyrin 3, node of Ranvier (ankyrin G)",TRUE
+"1552438_a_at",0.750402030437619,0.243371584441992,1.19853496876228,-5.2632425814412,0.638083379535145,"ANKAR","ankyrin and armadillo repeat containing",TRUE
+"1556653_at",0.796466121438385,0.329227013784574,0.99763642185599,-5.4662091521788,0.674820771959369,"ANKAR","ankyrin and armadillo repeat containing",TRUE
+"229497_at",0.6543319865054,0.123331971892001,1.60193569032218,-4.76156474975148,1.45875439009007,"ANKDD1A","ankyrin repeat and death domain containing 1A",TRUE
+"237316_at",0.961899417580562,0.826982737701777,-0.221173720897348,-5.91588546377265,-0.123520665294995,"ANKDD1A","ankyrin repeat and death domain containing 1A",TRUE
+"222951_s_at",0.976422537443518,0.887901891419663,-0.142591064948322,-5.92978525951675,-0.0604555939447611,"ANKEF1","ankyrin repeat and EF-hand domain containing 1",TRUE
+"220144_s_at",0.994217597763908,0.97369656506157,-0.0333468711916093,-5.93914187433196,-0.0189987592293264,"ANKEF1","ankyrin repeat and EF-hand domain containing 1",TRUE
+"244095_at",0.663325052838397,0.131357723176966,1.56669512323464,-4.81004425851432,0.971470635255231,"ANKFN1","ankyrin repeat and fibronectin type III domain containing 1",TRUE
+"1559640_at",0.915421702513799,0.643513203049526,0.46919671036715,-5.8330238137663,0.293890890785325,"ANKFN1","ankyrin repeat and fibronectin type III domain containing 1",TRUE
+"1553211_at",0.972680171456902,0.867895787188385,-0.168272127806624,-5.92590144340937,-0.144504675737034,"ANKFN1","ankyrin repeat and fibronectin type III domain containing 1",TRUE
+"219868_s_at",0.417580957608354,0.0170622013588855,2.57911742832729,-3.13377879251018,0.664916506676215,"ANKFY1","ankyrin repeat and FYVE domain containing 1",TRUE
+"239073_at",0.523369751179323,0.0388314974949319,2.19621738096872,-3.82921930047993,1.77136471156037,"ANKFY1","ankyrin repeat and FYVE domain containing 1",TRUE
+"224900_at",0.662015916975184,0.129930494412261,1.57282873854553,-4.80166706545171,0.414188527541148,"ANKFY1","ankyrin repeat and FYVE domain containing 1",TRUE
+"1562495_at",0.968451827985008,0.852113618452214,0.188612266899221,-5.92237125002908,0.143795672049733,"ANKFY1","ankyrin repeat and FYVE domain containing 1",TRUE
+"1560370_x_at",0.358427723880268,0.00995267123747213,2.81897221556291,-2.66972285807474,1.02179580811653,"ANKH","ANKH inorganic pyrophosphate transport regulator",TRUE
+"1560369_at",0.62932992642067,0.100188209277329,1.71559884161135,-4.5995767380188,0.980691217258584,"ANKH","ANKH inorganic pyrophosphate transport regulator",TRUE
+"229176_at",0.663789119801086,0.13170902450868,1.56519385497726,-4.81209075040565,1.21383833650652,"ANKH","ANKH inorganic pyrophosphate transport regulator",TRUE
+"223093_at",0.683017520100356,0.151426828081883,1.48578531470384,-4.91811462497588,1.36169511306365,"ANKH","ANKH inorganic pyrophosphate transport regulator",TRUE
+"223092_at",0.803111243433434,0.340781877007517,0.973565875910514,-5.48828274368943,1.24025462734212,"ANKH","ANKH inorganic pyrophosphate transport regulator",TRUE
+"223094_s_at",0.805832406059002,0.346062092259083,0.962752559926736,-5.49803891333376,1.44646715116995,"ANKH","ANKH inorganic pyrophosphate transport regulator",TRUE
+"220076_at",0.884576661578326,0.543850836377786,0.616494893318463,-5.75624369833958,0.643629180181985,"ANKH","ANKH inorganic pyrophosphate transport regulator",TRUE
+"229457_at",0.916349280948806,0.646808762632049,-0.464518164787815,-5.83512937982944,-0.183770446536582,"ANKHD1","ankyrin repeat and KH domain containing 1",TRUE
+"208773_s_at",0.758048998487985,0.254637913236952,-1.16947963000522,-5.29462490704822,-0.417684406672592,"ANKHD1-EIF4EBP3///ANKHD1","ANKHD1-EIF4EBP3 readthrough///ankyrin repeat and KH domain containing 1",TRUE
+"208772_at",0.802375933455311,0.340137163615809,-0.974894006658572,-5.48707759906389,-0.295674744579438,"ANKHD1-EIF4EBP3///ANKHD1","ANKHD1-EIF4EBP3 readthrough///ankyrin repeat and KH domain containing 1",TRUE
+"219081_at",0.841967750949524,0.434927939534115,0.795209808978601,-5.63629085185745,0.270707772588814,"ANKHD1-EIF4EBP3///ANKHD1","ANKHD1-EIF4EBP3 readthrough///ankyrin repeat and KH domain containing 1",TRUE
+"233292_s_at",0.875132376583655,0.52199025267757,-0.650607174210726,-5.73559130281673,-0.217593347311684,"ANKHD1-EIF4EBP3///ANKHD1","ANKHD1-EIF4EBP3 readthrough///ankyrin repeat and KH domain containing 1",TRUE
+"214919_s_at",0.834654118013092,0.413212943143637,-0.833944746249158,-5.60650943517511,-0.282863098087365,"ANKHD1-EIF4EBP3///ANKHD1///EIF4EBP3","ANKHD1-EIF4EBP3 readthrough///ankyrin repeat and KH domain containing 1///eukaryotic translation initiation factor 4E binding protein 3",TRUE
+"224687_at",0.590570903980459,0.0683409622219362,1.91611723723244,-4.29402946537775,0.613972641745264,"ANKIB1","ankyrin repeat and IBR domain containing 1",TRUE
+"243181_at",0.707230505488426,0.178777006243357,1.38853365235072,-5.04185975359113,0.876793161816623,"ANKIB1","ankyrin repeat and IBR domain containing 1",TRUE
+"224682_at",0.899331416659389,0.590096288480212,0.54662964930664,-5.79518572804867,0.148958738986734,"ANKIB1","ankyrin repeat and IBR domain containing 1",TRUE
+"1553138_a_at",0.486555742735298,0.028654951835531,2.34058158334159,-3.57439892724982,1.71219489557063,"ANKLE1","ankyrin repeat and LEM domain containing 1",TRUE
+"212201_at",0.421475143999873,0.0175527920052622,2.56629358685456,-3.15803258404336,0.781506127348278,"ANKLE2","ankyrin repeat and LEM domain containing 2",TRUE
+"213962_s_at",0.42796179417767,0.0184333392881906,2.5440956169767,-3.19987167771708,1.58794685657854,"ANKLE2","ankyrin repeat and LEM domain containing 2",TRUE
+"212200_at",0.792778640449105,0.324564372890951,1.00751479843158,-5.45700862309982,0.386023647881707,"ANKLE2","ankyrin repeat and LEM domain containing 2",TRUE
+"220280_s_at",0.839519981963042,0.427446188520443,0.808416426947331,-5.62628620636264,0.624586657884665,"ANKMY1","ankyrin repeat and MYND domain containing 1",TRUE
+"1554610_at",0.851319596585235,0.455208813628877,0.760097558077389,-5.66213455921551,0.405600704115811,"ANKMY1","ankyrin repeat and MYND domain containing 1",TRUE
+"210486_at",0.914562242038395,0.640078172751406,-0.474084596124297,-5.83080197317535,-0.313262827143922,"ANKMY1","ankyrin repeat and MYND domain containing 1",TRUE
+"212798_s_at",0.55074985379986,0.0491223395098855,2.0817544448723,-4.02414449323613,0.961054901728479,"ANKMY2","ankyrin repeat and MYND domain containing 2",TRUE
+"218769_s_at",0.939356991756184,0.728497762495578,-0.351548914589794,-5.87966760087322,-0.131602893399712,"ANKRA2","ankyrin repeat family A member 2",TRUE
+"206029_at",0.986844665519238,0.938419117759832,0.0781386800137003,-5.93671007963211,0.0832557005573857,"ANKRD1","ankyrin repeat domain 1",TRUE
+"223251_s_at",0.173567125989145,0.00152694627527716,3.61362072100496,-1.02964054443208,1.95930885964097,"ANKRD10","ankyrin repeat domain 10",TRUE
+"241414_at",0.950961978103462,0.776124640644422,0.287866167096183,-5.89940245711753,0.129401014631461,"ANKRD10","ankyrin repeat domain 10",TRUE
+"218093_s_at",0.969882914559333,0.857077811220111,0.182206022159012,-5.92352637945473,0.103759633015356,"ANKRD10","ankyrin repeat domain 10",TRUE
+"239116_at",0.989654520357877,0.950143792872901,0.0632382980771084,-5.9377358628826,0.0527141399830724,"ANKRD10","ankyrin repeat domain 10",TRUE
+"226663_at",0.386869932746877,0.0127360428826153,2.71013117136039,-2.88265394000895,1.5371491401639,"ANKRD10-IT1","ANKRD10 intronic transcript 1",TRUE
+"215504_x_at",0.645636413659377,0.116645569165566,1.63278732524563,-4.7184365265388,0.687656432040043,"ANKRD10-IT1","ANKRD10 intronic transcript 1",TRUE
+"219437_s_at",0.692728103625751,0.162213039062103,1.44586400552604,-4.96973806521234,0.562354127997855,"ANKRD11","ankyrin repeat domain 11",TRUE
+"231999_at",0.711031110506526,0.18477055359994,1.3688320435083,-5.06608739560044,0.376011307243011,"ANKRD11","ankyrin repeat domain 11",TRUE
+"226012_at",0.899808883319249,0.593013052856271,0.542317508231963,-5.79744058051369,0.180614745474886,"ANKRD11","ankyrin repeat domain 11",TRUE
+"238538_at",0.90344422113846,0.603987547665874,-0.526184733945245,-5.80572247410354,-0.159283706825212,"ANKRD11","ankyrin repeat domain 11",TRUE
+"228356_at",0.94895689004559,0.767614294663572,0.299149068243502,-5.89618987110115,0.143716872589479,"ANKRD11","ankyrin repeat domain 11",TRUE
+"234701_at",0.996504576103163,0.982689295468756,-0.0219436910319123,-5.93944895011617,-0.00921960355170448,"ANKRD11","ankyrin repeat domain 11",TRUE
+"216550_x_at",0.420316373451853,0.0174353458617065,2.56933273452502,-3.15229010206551,0.946824113370042,"ANKRD12","ankyrin repeat domain 12",TRUE
+"212289_at",0.727286289873957,0.20751002409762,1.29837754253998,-5.15035013791745,0.562758202577626,"ANKRD12","ankyrin repeat domain 12",TRUE
+"216563_at",0.740587184077449,0.229876636506235,1.23470014165736,-5.22324784742422,0.855075285131185,"ANKRD12","ankyrin repeat domain 12",TRUE
+"212286_at",0.770957614026379,0.27948009780165,1.10862755114019,-5.35815494402856,0.415453883728246,"ANKRD12","ankyrin repeat domain 12",TRUE
+"238851_at",0.768852835478002,0.273429282001828,1.12307176945331,-5.34334632249593,0.868383508114207,"ANKRD13A","ankyrin repeat domain 13A",TRUE
+"224810_s_at",0.871165715950006,0.511777733842365,0.666810873437161,-5.7254072252454,0.346091626950171,"ANKRD13A","ankyrin repeat domain 13A",TRUE
+"227720_at",0.952082954955992,0.780902013012852,0.281549168952941,-5.90114760045991,0.0937245892057827,"ANKRD13B","ankyrin repeat domain 13B",TRUE
+"227375_at",0.73957587762701,0.227898268610888,-1.24013623509035,-5.21714738401835,-0.454513659179083,"ANKRD13C","ankyrin repeat domain 13C",TRUE
+"223418_x_at",0.748438284778152,0.241167388455123,-1.20433682453033,-5.25689577646012,-0.430480669620598,"ANKRD13C","ankyrin repeat domain 13C",TRUE
+"238597_at",0.920169584950428,0.660312126079518,-0.445456151431887,-5.8434943980962,-0.155684868703381,"ANKRD13C","ankyrin repeat domain 13C",TRUE
+"1556361_s_at",0.948429371744093,0.765675423909184,0.301725097100239,-5.89543922772177,0.260891394118604,"ANKRD13C","ankyrin repeat domain 13C",TRUE
+"1554471_a_at",0.999369827418759,0.998096409750964,0.00241286165906523,-5.93968064511599,0.000895234958594671,"ANKRD13C","ankyrin repeat domain 13C",TRUE
+"244756_at",0.675622576285316,0.142063217967149,1.52236411191185,-4.86982155875814,0.585517198064788,"ANKRD13D","ankyrin repeat domain 13D",TRUE
+"226205_at",0.900692252557887,0.595805478403241,0.538198913439377,-5.79957801762932,0.197096185433724,"ANKRD13D","ankyrin repeat domain 13D",TRUE
+"238642_at",0.924812035112346,0.674863293587789,0.425100789129398,-5.8520472108198,0.313690396152871,"ANKRD13D","ankyrin repeat domain 13D",TRUE
+"231423_s_at",0.432151440378733,0.0193426159742854,-2.52219026030239,-3.24097753334243,-1.50433314883023,"ANKRD16","ankyrin repeat domain 16",TRUE
+"229058_at",0.741186481976394,0.231534494325292,-1.23017205760093,-5.22831169142752,-0.383229471291163,"ANKRD16","ankyrin repeat domain 16",TRUE
+"212211_at",0.76524135343539,0.265390215358468,-1.14262831032859,-5.32302654309501,-0.357689834777874,"ANKRD17","ankyrin repeat domain 17",TRUE
+"225852_at",0.958723944343516,0.812860958485603,-0.239576535808797,-5.91176616173775,-0.0852786343015115,"ANKRD17","ankyrin repeat domain 17",TRUE
+"1559313_at",0.723655063748891,0.200629723819894,1.31902960203126,-5.12603891124231,0.857797644436158,"ANKRD18A","ankyrin repeat domain 18A",TRUE
+"1559406_at",0.76743169976232,0.269397651825116,1.13282596514773,-5.33325014987429,0.633238784764492,"ANKRD18A","ankyrin repeat domain 18A",TRUE
+"244297_at",0.847527520228882,0.446353294643293,0.775309401910117,-5.65107331118982,0.648608924526026,"ANKRD18A","ankyrin repeat domain 18A",TRUE
+"233592_at",0.866077812635028,0.496822618608815,-0.690869103065306,-5.70984433410421,-0.409292519038558,"ANKRD18B","ankyrin repeat domain 18B",TRUE
+"232926_x_at",0.657015752622694,0.125215327167107,1.59349833898544,-4.77324838364915,0.610532069792728,"ANKRD19P","ankyrin repeat domain 19, pseudogene",TRUE
+"221232_s_at",0.81390353381761,0.36484876911899,0.925162603498389,-5.53117676402883,1.00655594572499,"ANKRD2","ankyrin repeat domain 2",TRUE
+"241233_x_at",0.758966211371161,0.256402876354099,-1.16501517646154,-5.29938723263909,-0.876156655965284,"ANKRD20A11P","ankyrin repeat domain 20 family member A11, pseudogene",TRUE
+"1566147_a_at",0.734817070946106,0.219739535619,1.26294239700725,-5.19130316346144,0.412330586468779,"ANKRD20A12P","ankyrin repeat domain 20 family member A12, pseudogene",TRUE
+"1558982_at",0.94630837494651,0.756826675980028,-0.31350855005829,-5.89192426809159,-0.104922640031511,"ANKRD20A12P","ankyrin repeat domain 20 family member A12, pseudogene",TRUE
+"1570255_s_at",0.826842911318947,0.395095703372626,-0.86725920312109,-5.57983769017196,-0.900054475051284,"ANKRD20A12P///ANKRD20A8P///ANKRD20A4///ANKRD20A2///ANKRD20A3///ANKRD20A5P///ANKRD20A1","ankyrin repeat domain 20 family member A12, pseudogene///ankyrin repeat domain 20 family member A8, pseudogene///ankyrin repeat domain 20 family member A4///ankyrin repeat domain 20 family member A2///ankyrin repeat domain 20 family member A3///ankyrin repeat domain 20 family member A5, pseudogene///ankyrin repeat domain 20 family member A1",TRUE
+"224012_at",0.753862100951903,0.247087382291664,-1.1888429717778,-5.27378543036361,-1.03300746722315,"ANKRD20A4///ANKRD20A2///ANKRD20A3///ANKRD20A1","ankyrin repeat domain 20 family member A4///ankyrin repeat domain 20 family member A2///ankyrin repeat domain 20 family member A3///ankyrin repeat domain 20 family member A1",TRUE
+"1559170_at",0.562414216355319,0.0550237626416324,-2.02552866204171,-4.11742935506567,-1.8056413919412,"ANKRD20A5P","ankyrin repeat domain 20 family member A5, pseudogene",TRUE
+"239196_at",0.782471668844017,0.304838977193381,1.05043931748527,-5.41607904322528,0.630347274975865,"ANKRD22","ankyrin repeat domain 22",TRUE
+"238439_at",0.839519981963042,0.427218755548615,0.808820125618703,-5.62597794762887,0.988349878762423,"ANKRD22","ankyrin repeat domain 22",TRUE
+"230384_at",0.776696310319783,0.29406730920518,-1.0747145744467,-5.3922530861311,-0.824932376224345,"ANKRD23","ankyrin repeat domain 23",TRUE
+"1553366_s_at",0.831875452294783,0.407205572855821,-0.844885942822341,-5.5978573066257,-0.641947761764928,"ANKRD23///ANKRD39","ankyrin repeat domain 23///ankyrin repeat domain 39",TRUE
+"229052_at",0.944257131022797,0.750345488277046,-0.322167969446205,-5.88925618288478,-0.240228355986273,"ANKRD23///ANKRD39","ankyrin repeat domain 23///ankyrin repeat domain 39",TRUE
+"1558400_x_at",0.380084968057051,0.0117893330944409,2.74437428953611,-2.81606374838345,1.88396868539127,"ANKRD24","ankyrin repeat domain 24",TRUE
+"1558398_at",0.718706241731185,0.194568437543633,1.33768602245025,-5.10379888364843,0.769710019354513,"ANKRD24","ankyrin repeat domain 24",TRUE
+"233895_at",0.816800680706682,0.367924659564656,0.919132779419054,-5.53637951911514,0.583525847655326,"ANKRD24","ankyrin repeat domain 24",TRUE
+"205705_at",0.940668681806864,0.734364620172019,0.343629191490444,-5.88233365178156,0.160920513141863,"ANKRD26","ankyrin repeat domain 26",TRUE
+"205706_s_at",0.971216837324271,0.862758669732046,0.174884472869049,-5.92479782981672,0.098766648876988,"ANKRD26","ankyrin repeat domain 26",TRUE
+"1569996_at",0.826134344333512,0.393863940405547,-0.869559514604198,-5.57796015749831,-0.409465886366922,"ANKRD26P3","ankyrin repeat domain 26 pseudogene 3",TRUE
+"221522_at",0.834265235157814,0.412335399914956,-0.835536686623562,-5.60525710368915,-0.293217640394731,"ANKRD27","ankyrin repeat domain 27",TRUE
+"229307_at",0.764430688544079,0.264513628213039,1.1447869681889,-5.3207646890134,1.39238196788189,"ANKRD28","ankyrin repeat domain 28",TRUE
+"1561079_at",0.804285900140645,0.342963086394175,0.969085219811709,-5.49233742687036,0.484589208789907,"ANKRD28","ankyrin repeat domain 28",TRUE
+"213035_at",0.827985973549523,0.39757524039781,0.862642687747032,-5.58359177135589,0.440652875427928,"ANKRD28","ankyrin repeat domain 28",TRUE
+"226025_at",0.961212424803935,0.823882505053375,0.225206881804016,-5.91501069272682,0.0937476477211909,"ANKRD28","ankyrin repeat domain 28",TRUE
+"229308_at",0.966064677476069,0.841873094834885,0.201853447775033,-5.91985764668132,0.196772871790058,"ANKRD29","ankyrin repeat domain 29",TRUE
+"238332_at",0.968035667633768,0.849124901546773,-0.192473059705437,-5.92165589028802,-0.179741278685228,"ANKRD29","ankyrin repeat domain 29",TRUE
+"223864_at",0.761748280722165,0.261200967573697,-1.15299257136629,-5.31213254367276,-2.54216042701267,"ANKRD30A","ankyrin repeat domain 30A",TRUE
+"1562294_x_at",0.433660982257499,0.0195920976951589,-2.51634811102711,-3.25190955379478,-2.94149240237685,"ANKRD30B","ankyrin repeat domain 30B",TRUE
+"1562292_at",0.921919360038633,0.66693707548624,-0.436165434207633,-5.84744683956572,-0.513007677054932,"ANKRD30B","ankyrin repeat domain 30B",TRUE
+"1552895_a_at",0.597654932724127,0.0744629279256788,-1.87202301433512,-4.36328595418225,-0.872722987900025,"ANKRD30BP2","ankyrin repeat domain 30B pseudogene 2",TRUE
+"1570473_at",0.71758664251404,0.193325125637527,1.34156900118136,-5.09913704645602,0.599080147433893,"ANKRD30BP3","ankyrin repeat domain 30B pseudogene 3",TRUE
+"1570474_s_at",0.768852835478002,0.272341309949091,1.12569360165912,-5.34064015352384,1.04245133127503,"ANKRD30BP3","ankyrin repeat domain 30B pseudogene 3",TRUE
+"1561225_at",0.839026687117702,0.424730719230236,0.813245221332549,-5.62258953884511,0.290861913675339,"ANKRD30BP3","ankyrin repeat domain 30B pseudogene 3",TRUE
+"1564000_at",0.88084879167122,0.536741807833898,0.627505589865915,-5.74969451363324,0.281235866469531,"ANKRD31","ankyrin repeat domain 31",TRUE
+"242209_at",0.9286288141895,0.686247660062519,-0.409302187460535,-5.85841440931653,-0.243958634519235,"ANKRD33","ankyrin repeat domain 33",TRUE
+"231963_at",0.41173827666364,0.0163788843267672,2.59756721588134,-3.09877924699539,3.17374099851388,"ANKRD33B","ankyrin repeat domain 33B",TRUE
+"232735_at",0.623667408398064,0.0951740485748451,-1.74312856784846,-4.55908668837302,-1.76722783844786,"ANKRD34A","ankyrin repeat domain 34A",TRUE
+"216073_at",0.9286288141895,0.686327604071029,0.409191624061337,-5.85845813318534,0.344475864210854,"ANKRD34C","ankyrin repeat domain 34C",TRUE
+"231118_at",0.553930058946379,0.0506726527094507,2.06642226026105,-4.04974768143797,1.07882858986159,"ANKRD35","ankyrin repeat domain 35",TRUE
+"214723_x_at",0.942303845415102,0.74021408008354,0.335755198705626,-5.88492476253687,0.157036870106658,"ANKRD36","ankyrin repeat domain 36",TRUE
+"238464_at",0.96287357728432,0.831551155507678,0.215237375354054,-5.91714440181366,0.111723699193405,"ANKRD36","ankyrin repeat domain 36",TRUE
+"220940_at",0.828426831961877,0.398336444304699,0.861229169317551,-5.58473749558887,0.532609733019338,"ANKRD36B","ankyrin repeat domain 36B",TRUE
+"1569040_s_at",0.596091103607107,0.0726320792360411,1.88486668456818,-4.34322968800766,1.97832933522819,"ANKRD36BP2","ankyrin repeat domain 36B pseudogene 2",TRUE
+"1556183_at",0.837067957688307,0.419507865990412,0.822587329566599,-5.61537912993857,0.260281535908886,"ANKRD36BP2","ankyrin repeat domain 36B pseudogene 2",TRUE
+"216686_at",0.97304633500821,0.868982243121478,0.166874667406385,-5.92612925319284,0.166061037593342,"ANKRD36BP2","ankyrin repeat domain 36B pseudogene 2",TRUE
+"1555898_at",0.929972194057784,0.691003876538164,0.402733256310055,-5.86099201212374,0.164917768941275,"ANKRD36C","ankyrin repeat domain 36C",TRUE
+"242548_x_at",0.820536502908875,0.380697461185799,0.894445234410893,-5.55735333858207,0.50297990924172,"ANKRD37","ankyrin repeat domain 37",TRUE
+"227337_at",0.853460708803218,0.462156583548914,0.748287148014565,-5.67057949651648,0.542297274082872,"ANKRD37","ankyrin repeat domain 37",TRUE
+"223532_at",0.978951900396372,0.897728637567166,-0.130013814119482,-5.93145371658463,-0.073565876534543,"ANKRD39","ankyrin repeat domain 39",TRUE
+"227064_at",0.746259710622309,0.237941839352687,-1.21289944563709,-5.2474803084538,-0.537211900795189,"ANKRD40","ankyrin repeat domain 40",TRUE
+"211717_at",0.791485967600196,0.322019067440084,-1.01294903008266,-5.45191226043475,-0.549196657592402,"ANKRD40","ankyrin repeat domain 40",TRUE
+"241032_at",0.908013878860707,0.618392264953874,-0.505221113758365,-5.81612031222754,-0.285371013026468,"ANKRD40","ankyrin repeat domain 40",TRUE
+"232600_at",0.635916735157933,0.106950532172209,-1.68027233572443,-4.65082585216307,-0.80939628927134,"ANKRD42","ankyrin repeat domain 42",TRUE
+"228471_at",0.55937703282623,0.0538059230908284,-2.03667495500136,-4.09906974124617,-0.947252883041577,"ANKRD44","ankyrin repeat domain 44",TRUE
+"226641_at",0.635368778245437,0.10625013332563,-1.68384177571319,-4.64568407977341,-1.00954729853703,"ANKRD44","ankyrin repeat domain 44",TRUE
+"233361_at",0.937113154905832,0.719957654694916,0.363118537328477,-5.87566500123508,0.241764369082616,"ANKRD44","ankyrin repeat domain 44",TRUE
+"235778_s_at",0.946579549170519,0.75804510417505,-0.311883374280967,-5.8924169825679,-0.211808954558761,"ANKRD44","ankyrin repeat domain 44",TRUE
+"235777_at",0.957813759927439,0.810359984828003,-0.242844331442444,-5.91100047739976,-0.236412942487231,"ANKRD44","ankyrin repeat domain 44",TRUE
+"1557486_at",0.882092375733396,0.539595267135872,-0.623076743298349,-5.75234222599421,-0.626746500335875,"ANKRD44-IT1","ANKRD44 intronic transcript 1",TRUE
+"236421_at",0.85334340854827,0.461420102092142,0.749534024590986,-5.66969383914115,0.647021817605182,"ANKRD45","ankyrin repeat domain 45",TRUE
+"212731_at",0.682139937733475,0.14971521267127,-1.49233104118192,-4.9095418693063,-0.708228886851307,"ANKRD46","ankyrin repeat domain 46",TRUE
+"219069_at",0.988706054965124,0.945360313515624,0.0693154473856524,-5.93734359293949,0.0246344693976539,"ANKRD49","ankyrin repeat domain 49",TRUE
+"225731_at",0.626839388794963,0.0972646354518365,-1.73150332933321,-4.57624327864562,-0.764365533965206,"ANKRD50","ankyrin repeat domain 50",TRUE
+"225735_at",0.794812714107118,0.326979129163301,-1.00238663251222,-5.46179516135283,-0.483546410430124,"ANKRD50","ankyrin repeat domain 50",TRUE
+"236189_at",0.831182446031643,0.40531156222983,-0.848356778196676,-5.59509063183251,-0.821590114947187,"ANKRD50","ankyrin repeat domain 50",TRUE
+"228257_at",0.329593230108883,0.00789026539212697,-2.92026827378181,-2.46838212475676,-1.0671385907336,"ANKRD52","ankyrin repeat domain 52",TRUE
+"215759_at",0.308861881799719,0.00644614177523531,3.00761238937391,-2.29254170757252,1.66708989453025,"ANKRD53","ankyrin repeat domain 53",TRUE
+"244453_at",0.852788508992415,0.458871038033082,0.753858841790972,-5.66661109841596,0.399279767695578,"ANKRD53","ankyrin repeat domain 53",TRUE
+"231847_at",0.780237570670818,0.301711952525475,-1.05742262509734,-5.40927498995192,-0.330694449059926,"ANKRD54","ankyrin repeat domain 54",TRUE
+"1558193_at",0.949217179291784,0.770795767289348,-0.294926553567034,-5.89740649010838,-0.168913262942426,"ANKRD54","ankyrin repeat domain 54",TRUE
+"220112_at",0.83030603167465,0.40237967272727,0.853750059605405,-5.59077055111046,0.531676519367876,"ANKRD55","ankyrin repeat domain 55",TRUE
+"204671_s_at",0.90881571130962,0.621352356734612,0.500941774023894,-5.81819217323532,0.689186023277144,"ANKRD6","ankyrin repeat domain 6",TRUE
+"204672_s_at",0.965707350334601,0.839813334938258,0.204521142142426,-5.91933067850781,0.171829884392857,"ANKRD6","ankyrin repeat domain 6",TRUE
+"234511_at",0.863774839857238,0.489575098533808,0.702676132942122,-5.70201388062576,0.29448832506639,"ANKRD60","ankyrin repeat domain 60",TRUE
+"1556181_at",0.425751189365875,0.0181695448372215,2.5506397432145,-3.18755632600176,1.7446615330826,"ANKRD65","ankyrin repeat domain 65",TRUE
+"1556182_x_at",0.756313947022433,0.251532865262425,1.17738998718773,-5.28614763399542,0.860503832487749,"ANKRD65","ankyrin repeat domain 65",TRUE
+"206112_at",0.839519981963042,0.427070846538144,0.809082739283674,-5.62577734190976,0.880519840175176,"ANKRD7","ankyrin repeat domain 7",TRUE
+"227959_at",0.690850498237822,0.160541514609142,-1.45190706158497,-4.96199690869368,-0.567115667012985,"ANKRD9","ankyrin repeat domain 9",TRUE
+"244245_at",0.79943091106207,0.334081051826602,0.987454949443894,-5.4756058031213,0.737254123163343,"ANKRD9","ankyrin repeat domain 9",TRUE
+"230972_at",0.920389295526597,0.661172416122487,-0.444247460000452,-5.84401322313065,-0.183428436869573,"ANKRD9","ankyrin repeat domain 9",TRUE
+"212747_at",0.692723028939505,0.16216117142015,1.44605076540772,-4.96949921952759,0.42482555570362,"ANKS1A","ankyrin repeat and sterile alpha motif domain containing 1A",TRUE
+"227439_at",0.308861881799719,0.00643974503126897,-3.0080395918863,-2.29167690391458,-2.54604946439058,"ANKS1B","ankyrin repeat and sterile alpha motif domain containing 1B",TRUE
+"240292_x_at",0.563547120625998,0.0557208181820602,-2.019247364352,-4.12774617987116,-1.14515238793393,"ANKS1B","ankyrin repeat and sterile alpha motif domain containing 1B",TRUE
+"227441_s_at",0.609499207369658,0.0817106299858638,-1.82373856252469,-4.43781330092836,-2.06469713913241,"ANKS1B","ankyrin repeat and sterile alpha motif domain containing 1B",TRUE
+"227440_at",0.861357981297227,0.481760602470231,-0.715520098758831,-5.69335213858043,-0.654636544631729,"ANKS1B","ankyrin repeat and sterile alpha motif domain containing 1B",TRUE
+"219989_s_at",0.975159323713639,0.879028203039826,0.153968712509682,-5.92814357661646,0.121350465495424,"ANKS1B","ankyrin repeat and sterile alpha motif domain containing 1B",TRUE
+"227303_at",0.955966019701688,0.801122880995339,0.25493738389036,-5.90807723810378,0.132171306935576,"ANKS3","ankyrin repeat and sterile alpha motif domain containing 3",TRUE
+"239087_at",0.940044918888428,0.730995644549568,-0.348174229288268,-5.88081097702988,-0.190893190043647,"ANKS4B","ankyrin repeat and sterile alpha motif domain containing 4B",TRUE
+"226586_at",0.51531387545335,0.0358625513903921,2.23437050600496,-3.762815146801,2.55717596724128,"ANKS6","ankyrin repeat and sterile alpha motif domain containing 6",TRUE
+"238626_at",0.552420073963858,0.0496484378719832,2.0765034844073,-4.03292688182428,1.62704036613231,"ANKS6","ankyrin repeat and sterile alpha motif domain containing 6",TRUE
+"1554923_at",0.592253441512655,0.069326420222789,1.90879142022226,-4.30561365769206,1.50043201487288,"ANKS6","ankyrin repeat and sterile alpha motif domain containing 6",TRUE
+"235903_at",0.677013732819214,0.144256065835648,1.51362477804477,-4.88144505028745,1.48499141951852,"ANKS6","ankyrin repeat and sterile alpha motif domain containing 6",TRUE
+"1561928_s_at",0.438807740024285,0.0201606775114953,2.50328867542952,-3.27629924981389,0.79481539822151,"ANKUB1","ankyrin repeat and ubiquitin domain containing 1",TRUE
+"1562562_at",0.626253409795776,0.0970772816295826,-1.73253639847884,-4.5747221203492,-1.15493298020321,"ANKUB1","ankyrin repeat and ubiquitin domain containing 1",TRUE
+"1561927_at",0.822850703882235,0.388314526430582,0.879981248901093,-5.56939599188235,0.784280593438406,"ANKUB1","ankyrin repeat and ubiquitin domain containing 1",TRUE
+"218274_s_at",0.959356077764139,0.815732628655002,0.235827668593793,-5.91263186077471,0.107879927720851,"ANKZF1","ankyrin repeat and zinc finger domain containing 1",TRUE
+"1552619_a_at",0.628084912651991,0.0994877595876738,1.71937293053687,-4.59405431159411,0.762178912033381,"ANLN","anillin actin binding protein",TRUE
+"222608_s_at",0.67397614409571,0.140560701045241,1.52841633561186,-4.86174074706021,0.689676033326466,"ANLN","anillin actin binding protein",TRUE
+"218804_at",0.872668627020452,0.516767756300257,0.65887129885662,-5.73042729018634,1.51249633753952,"ANO1","anoctamin 1",TRUE
+"1555269_a_at",0.986052747771532,0.931731926988947,0.086645043976586,-5.9360275821195,0.114686626997271,"ANO1","anoctamin 1",TRUE
+"218910_at",0.923729367266399,0.672453222198061,-0.428459372571461,-5.85066307901926,-0.12805670177565,"ANO10","anoctamin 10",TRUE
+"220111_s_at",0.624331975868069,0.0957829009928292,-1.73972053447877,-4.56412510331956,-1.47925326645135,"ANO2","anoctamin 2",TRUE
+"234718_at",0.647518308302168,0.118343404723534,1.62481585280818,-4.72964088496321,0.560263775929871,"ANO2","anoctamin 2",TRUE
+"215241_at",0.88782282220852,0.553153807746378,0.602200986900343,-5.76457894988183,0.522785717033948,"ANO3","anoctamin 3",TRUE
+"229749_at",0.580630437263151,0.0632150289903946,1.95579177344975,-4.23076175045487,1.31555438321672,"ANO4","anoctamin 4",TRUE
+"239883_s_at",0.728385463227073,0.208718569246477,-1.29480503958516,-5.15452263528338,-0.857441862561039,"ANO4","anoctamin 4",TRUE
+"236420_s_at",0.923708852928185,0.672244600078766,0.428750335567305,-5.85054266428168,0.204000435825257,"ANO4","anoctamin 4",TRUE
+"229313_at",0.940044918888428,0.73079389820289,-0.348446638893345,-5.88071908642284,-0.436252779680511,"ANO5","anoctamin 5",TRUE
+"224906_at",0.91876780831279,0.65465981096424,-0.453414441011673,-5.84004382175928,-0.191364821407882,"ANO6","anoctamin 6",TRUE
+"240947_at",0.977860524436236,0.89269020054627,0.136459695129648,-5.93061782508693,0.0569795578386678,"ANO6","anoctamin 6",TRUE
+"241918_at",0.970526265934304,0.859415438702778,-0.179192052653109,-5.92405607567711,-0.141506607234649,"ANO7","anoctamin 7",TRUE
+"1563549_a_at",0.839519981963042,0.427528922774209,-0.808269604949057,-5.62639828179022,-0.330599880407654,"ANO8","anoctamin 8",TRUE
+"227393_at",0.725155137836843,0.203321961829699,1.31088388164311,-5.13566665753534,0.76097047629945,"ANO9","anoctamin 9",TRUE
+"205206_at",0.722442821599878,0.199024097554485,1.32392828983158,-5.12022473009374,1.07042223422457,"ANOS1","anosmin 1",TRUE
+"229853_at",0.94895689004559,0.767515783126382,0.299279903002109,-5.89615190023768,0.212062125283921,"ANOS1","anosmin 1",TRUE
+"201043_s_at",0.808830793519863,0.352039257309414,-0.950646650815585,-5.50884306885596,-0.347473677451701,"ANP32A","acidic nuclear phosphoprotein 32 family member A",TRUE
+"201038_s_at",0.839466826665106,0.425759288430487,-0.811413904919285,-5.62399392853601,-0.323881973916336,"ANP32A","acidic nuclear phosphoprotein 32 family member A",TRUE
+"201051_at",0.928244741861625,0.684524809597153,-0.411686171959138,-5.85746880173264,-0.137578497158671,"ANP32A","acidic nuclear phosphoprotein 32 family member A",TRUE
+"220710_at",0.969882914559333,0.857059070769313,0.18223019169694,-5.92352209613411,0.126121000007119,"ANP32A-IT1","ANP32A intronic transcript 1",TRUE
+"201306_s_at",0.89799228292133,0.586868957537173,0.551413182163184,-5.79266408511237,0.149631240015387,"ANP32B","acidic nuclear phosphoprotein 32 family member B",TRUE
+"201305_x_at",0.944801723928361,0.751864127274911,0.320136707484714,-5.88988850446146,0.102273346543749,"ANP32B","acidic nuclear phosphoprotein 32 family member B",TRUE
+"208538_at",0.851733415458562,0.45636099926445,-0.7581315333209,-5.66354903027384,-0.45957417800769,"ANP32C","acidic nuclear phosphoprotein 32 family member C",TRUE
+"208571_at",0.891918115867831,0.562031191071184,0.588678005766248,-5.77229079075928,0.519898994808049,"ANP32D","acidic nuclear phosphoprotein 32 family member D",TRUE
+"229128_s_at",0.807944276806637,0.349627468214929,0.955514475400115,-5.50451372342643,1.1488144075432,"ANP32E","acidic nuclear phosphoprotein 32 family member E",TRUE
+"221505_at",0.852371612067119,0.458101406800033,0.755167446200447,-5.6656750133744,0.764680298659506,"ANP32E","acidic nuclear phosphoprotein 32 family member E",TRUE
+"208103_s_at",0.858826390511142,0.475137594578985,0.726500850993762,-5.68582855721088,0.82807176067441,"ANP32E","acidic nuclear phosphoprotein 32 family member E",TRUE
+"202888_s_at",0.245492559900582,0.00334313257656709,3.28686908700215,-1.7185533162626,3.74896944908423,"ANPEP","alanyl aminopeptidase, membrane",TRUE
+"234576_at",0.809974507163816,0.353766643458106,-0.947174044619613,-5.51191915423368,-0.555043766879473,"ANPEP","alanyl aminopeptidase, membrane",TRUE
+"234458_at",0.901788521024914,0.59922720390348,-0.533164954130685,-5.80216898163692,-0.324210228149144,"ANPEP","alanyl aminopeptidase, membrane",TRUE
+"234430_at",0.556381379241158,0.0517787601336997,-2.05573775475906,-4.06751684550132,-1.00294102544897,"ANTXR1","anthrax toxin receptor 1",TRUE
+"234832_at",0.627092759817312,0.0987077949763803,1.72360220082733,-4.58785508081453,0.810612578831044,"ANTXR1","anthrax toxin receptor 1",TRUE
+"224694_at",0.732727727932114,0.217005264185964,1.27073056810473,-5.18238512976447,1.67405218869719,"ANTXR1","anthrax toxin receptor 1",TRUE
+"220092_s_at",0.744400501967131,0.235376239195387,1.21977290747088,-5.23988043236906,1.50877001457619,"ANTXR1","anthrax toxin receptor 1",TRUE
+"227660_at",0.766390367856479,0.266812622913152,1.13913667090152,-5.32667714144278,0.912579644701341,"ANTXR1","anthrax toxin receptor 1",TRUE
+"220093_at",0.868397087637799,0.503135080070052,0.680665125880017,-5.71650954138302,0.61538628465335,"ANTXR1","anthrax toxin receptor 1",TRUE
+"238050_at",0.758722841981575,0.255954904512409,1.16614614928608,-5.29818230932394,1.13894797495002,"ANTXR2","anthrax toxin receptor 2",TRUE
+"225524_at",0.776955214137673,0.295739360478499,1.07090523934943,-5.39602415464338,1.20665627323529,"ANTXR2","anthrax toxin receptor 2",TRUE
+"228573_at",0.819018525257656,0.375041166167371,0.905309231312922,-5.54818857444704,0.787688719478113,"ANTXR2","anthrax toxin receptor 2",TRUE
+"1555536_at",0.955816406528307,0.798531264433648,0.258337194108538,-5.90722998558156,0.279439623423825,"ANTXR2","anthrax toxin receptor 2",TRUE
+"201012_at",0.581128536542197,0.0636547627290123,1.95227916498338,-4.23639907271017,3.66692331271775,"ANXA1","annexin A1",TRUE
+"233011_at",0.835952408568777,0.417069663048412,0.826973545211268,-5.61196715883374,0.767828943502194,"ANXA1","annexin A1",TRUE
+"210143_at",0.557502997422893,0.05222581112565,2.05147725955382,-4.07458558545292,1.98583791981629,"ANXA10","annexin A10",TRUE
+"228727_at",0.492341486607851,0.0295709393734757,2.32580594871232,-3.60091508930762,1.84260148841178,"ANXA11","annexin A11",TRUE
+"214783_s_at",0.536186589417525,0.0430910700351564,2.14586224663222,-3.91578034264769,1.12249394908226,"ANXA11","annexin A11",TRUE
+"206200_s_at",0.695812999227098,0.165938027974299,1.43257551491555,-4.98666796413023,1.08138991696901,"ANXA11","annexin A11",TRUE
+"208323_s_at",0.48547305569508,0.0281067905864858,2.34963300869764,-3.55810804018207,1.30867578082019,"ANXA13","annexin A13",TRUE
+"213503_x_at",0.680586794685785,0.148274676371162,1.49788752506192,-4.90224093462858,0.572299707479464,"ANXA2","annexin A2",TRUE
+"201590_x_at",0.680586794685785,0.148338408436852,1.49764076647821,-4.90256562494644,0.58472483314222,"ANXA2","annexin A2",TRUE
+"210427_x_at",0.697172073261335,0.167497726733049,1.42708264311477,-4.99362869236811,0.531960601544553,"ANXA2","annexin A2",TRUE
+"1568126_at",0.766550448794594,0.267738689744327,1.13687076814878,-5.32904093151139,1.00124522469763,"ANXA2","annexin A2",TRUE
+"210876_at",0.869210945057612,0.506185212448731,0.675760584891001,-5.7196794287119,0.422066961334619,"ANXA2P1","annexin A2 pseudogene 1",TRUE
+"208816_x_at",0.672434875127089,0.13845729420252,1.53697893150975,-4.85026462696498,0.791710299210898,"ANXA2P2","annexin A2 pseudogene 2",TRUE
+"211241_at",0.593339168375633,0.0703704682014238,1.90112906144378,-4.31769697662142,0.70176019514772,"ANXA2P3","annexin A2 pseudogene 3",TRUE
+"227877_at",0.819018525257656,0.37469102991664,-0.905985275145621,-5.5476148912941,-0.589938225770174,"ANXA2R","annexin A2 receptor",TRUE
+"209369_at",0.565043084457947,0.0564254544381908,2.01296843369507,-4.13803782662405,2.44998558416084,"ANXA3","annexin A3",TRUE
+"201302_at",0.908756578207605,0.620962885447391,-0.501504281089326,-5.81792081481864,-0.197587067843893,"ANXA4","annexin A4",TRUE
+"201301_s_at",0.974982245454858,0.878426128813471,0.154741415854151,-5.92802752520006,0.0587973505984039,"ANXA4","annexin A4",TRUE
+"200782_at",0.794426378358553,0.32632363204559,-1.00377608841042,-5.46050045552634,-0.289757885218144,"ANXA5","annexin A5",TRUE
+"244250_at",0.635916735157933,0.107001637940051,-1.6800126612027,-4.65119959075687,-0.498344690375197,"ANXA6","annexin A6",TRUE
+"200982_s_at",0.697871681043328,0.168805108372371,-1.42250991535109,-4.99940667392772,-1.39932856321416,"ANXA6","annexin A6",TRUE
+"209860_s_at",0.861665593344139,0.483818064070373,0.712126812382685,-5.69565503325348,0.205728067167184,"ANXA7","annexin A7",TRUE
+"201366_at",0.966769992359004,0.84530158566839,0.19741635480717,-5.92071887162756,0.0660804967229662,"ANXA7","annexin A7",TRUE
+"203074_at",0.00510047304893181,1.30601961929667e-06,6.55746221191527,5.11538536121077,5.18260713191855,"ANXA8L1///ANXA8","annexin A8-like 1///annexin A8",TRUE
+"211712_s_at",0.895457620469779,0.574095580014644,-0.570475573204818,-5.78240360832618,-0.880841860217938,"ANXA9","annexin A9",TRUE
+"210085_s_at",0.942204696346004,0.739891333106826,-0.33618908197441,-5.88478353016725,-0.534668120779248,"ANXA9","annexin A9",TRUE
+"205639_at",0.996619671133734,0.983057987817346,-0.0214762470164862,-5.93945883551491,-0.0141180717248082,"AOAH","acyloxyacyl hydrolase",TRUE
+"203559_s_at",0.771527793162888,0.280826238897753,-1.10544510868314,-5.36139481689197,-1.27087005712533,"AOC1","amine oxidase, copper containing 1",TRUE
+"207064_s_at",0.861962516141708,0.484615496155223,0.710813892255186,-5.69654326570228,0.333893849073796,"AOC2","amine oxidase, copper containing 2",TRUE
+"204894_s_at",0.957396971369576,0.807137741167064,0.247058539101145,-5.90999781046266,0.121200820159344,"AOC3","amine oxidase, copper containing 3",TRUE
+"216601_at",0.594972224548427,0.0716324567626448,1.89199911406072,-4.33205033398561,0.73531415744281,"AOC4P","amine oxidase, copper containing 4, pseudogene",TRUE
+"205082_s_at",0.743323328391634,0.233377668822374,-1.22516661632636,-5.23389068540048,-0.919641521297083,"AOX1","aldehyde oxidase 1",TRUE
+"205083_at",0.87045636854107,0.509079600851118,-0.671121820591529,-5.72265735459681,-0.632253914020114,"AOX1","aldehyde oxidase 1",TRUE
+"1562871_at",0.865733085695438,0.495805302112319,0.692520456930082,-5.70875676933636,0.366538492355735,"AOX2P","aldehyde oxidase 2 pseudogene",TRUE
+"231010_at",0.806089660856733,0.34646932770764,-0.961923271954346,-5.49878301708005,-0.821821834247314,"AP1AR","adaptor related protein complex 1 associated regulatory protein",TRUE
+"219023_at",0.812432515576345,0.360965829241058,-0.932823210184684,-5.52452176866859,-0.370372847679249,"AP1AR","adaptor related protein complex 1 associated regulatory protein",TRUE
+"242753_x_at",0.895690630367785,0.576069451649935,-0.567516050930993,-5.78401876611161,-0.184643948530483,"AP1AR","adaptor related protein complex 1 associated regulatory protein",TRUE
+"205423_at",0.808266620412549,0.35117880049413,-0.952380750393762,-5.50730311736585,-0.38770710560474,"AP1B1","adaptor related protein complex 1 beta 1 subunit",TRUE
+"225771_at",0.679876113745083,0.14715416424434,-1.50224014708945,-4.89650660769846,-0.499488749904954,"AP1G1","adaptor related protein complex 1 gamma 1 subunit",TRUE
+"203350_at",0.684874883853079,0.153419039444558,-1.47824191638906,-4.92795634195039,-0.594402855958892,"AP1G1","adaptor related protein complex 1 gamma 1 subunit",TRUE
+"225754_at",0.745510155593313,0.237112692030325,-1.21511465254701,-5.24503505104677,-0.407966084165746,"AP1G1","adaptor related protein complex 1 gamma 1 subunit",TRUE
+"201613_s_at",0.774880457498598,0.291340946812005,-1.08095932330275,-5.3860451870128,-0.51165118216872,"AP1G2","adaptor related protein complex 1 gamma 2 subunit",TRUE
+"214341_at",0.989524702314661,0.948941106491945,-0.064766006601554,-5.93764063490039,-0.044123351610545,"AP1G2","adaptor related protein complex 1 gamma 2 subunit",TRUE
+"223024_at",0.966111788889917,0.842268627418364,-0.201341346532189,-5.91995801716119,-0.0868432705722242,"AP1M1","adaptor related protein complex 1 mu 1 subunit",TRUE
+"223025_s_at",0.97589003385521,0.884650912217834,0.146757080897719,-5.9291987313678,0.0674239380158124,"AP1M1","adaptor related protein complex 1 mu 1 subunit",TRUE
+"218261_at",0.92148618812595,0.665424615478079,0.438283019212706,-5.84655317433382,0.195026090650412,"AP1M2","adaptor related protein complex 1 mu 2 subunit",TRUE
+"65517_at",0.959356077764139,0.815663128169392,0.235918358093034,-5.91261107877784,0.120669327703157,"AP1M2","adaptor related protein complex 1 mu 2 subunit",TRUE
+"209635_at",0.451974019443452,0.0217132112704517,-2.46930278567973,-3.33945881077418,-1.09892794529463,"AP1S1","adaptor related protein complex 1 sigma 1 subunit",TRUE
+"205195_at",0.522339938465752,0.0380919732565335,-2.20546614738851,-3.81318610842846,-0.957767118051805,"AP1S1","adaptor related protein complex 1 sigma 1 subunit",TRUE
+"205196_s_at",0.730048787941067,0.212513707680916,-1.28368955510608,-5.16744243513057,-0.50783705949291,"AP1S1","adaptor related protein complex 1 sigma 1 subunit",TRUE
+"228415_at",0.610033432202476,0.0825328811054432,-1.81849827845453,-4.44581784024394,-1.2269231176311,"AP1S2","adaptor related protein complex 1 sigma 2 subunit",TRUE
+"230264_s_at",0.89497881904088,0.572409955611167,-0.573006991834031,-5.78101562853766,-0.610788168545028,"AP1S2","adaptor related protein complex 1 sigma 2 subunit",TRUE
+"203300_x_at",0.896159990898752,0.579202137297764,-0.562829538987842,-5.78655976645223,-0.48464340829358,"AP1S2","adaptor related protein complex 1 sigma 2 subunit",TRUE
+"203299_s_at",0.983935461205724,0.921373721483887,-0.0998342576064971,-5.9348301471524,-0.0926613566777528,"AP1S2","adaptor related protein complex 1 sigma 2 subunit",TRUE
+"1555734_x_at",0.384135218769668,0.0124707821365553,2.71947633649332,-2.86451869590189,1.64249555003367,"AP1S3","adaptor related protein complex 1 sigma 3 subunit",TRUE
+"1555731_a_at",0.425751189365875,0.0182526800065219,2.54856781972585,-3.19145720425232,1.73960452760898,"AP1S3","adaptor related protein complex 1 sigma 3 subunit",TRUE
+"1555733_s_at",0.446963972064621,0.021152342496746,2.48131166328931,-3.3171934478381,1.61382652230917,"AP1S3","adaptor related protein complex 1 sigma 3 subunit",TRUE
+"237159_x_at",0.580630437263151,0.063315330423973,1.9549886675882,-4.23205125072531,1.30243054878813,"AP1S3","adaptor related protein complex 1 sigma 3 subunit",TRUE
+"1555421_at",0.702920518369914,0.174854196369538,1.40171445029058,-5.02549092209192,1.27042794358487,"AP1S3","adaptor related protein complex 1 sigma 3 subunit",TRUE
+"1558792_x_at",0.820486855920536,0.379606399460902,0.896532517533538,-5.5556004674994,0.581488107213001,"AP2A1","adaptor related protein complex 2 alpha 1 subunit",TRUE
+"229617_x_at",0.85334340854827,0.460278181417591,-0.751469669510285,-5.66831618255686,-0.485414203809838,"AP2A1","adaptor related protein complex 2 alpha 1 subunit",TRUE
+"223237_x_at",0.878774484192636,0.531896943667006,-0.635054407188595,-5.7451399822394,-0.445818269875961,"AP2A1","adaptor related protein complex 2 alpha 1 subunit",TRUE
+"234068_s_at",0.934200936091995,0.708710800892013,-0.378432812191492,-5.87017019511273,-0.191057796890894,"AP2A1","adaptor related protein complex 2 alpha 1 subunit",TRUE
+"215764_x_at",0.730583674018334,0.213235560493545,1.28159272665823,-5.16986900142995,0.463148652457864,"AP2A2","adaptor related protein complex 2 alpha 2 subunit",TRUE
+"211779_x_at",0.901201392777064,0.59777074697919,0.535305946732294,-5.8010699133873,0.186881783806346,"AP2A2","adaptor related protein complex 2 alpha 2 subunit",TRUE
+"212159_x_at",0.919354071504066,0.656704409326656,0.450532300917263,-5.8413003882132,0.160967605968526,"AP2A2","adaptor related protein complex 2 alpha 2 subunit",TRUE
+"212161_at",0.93032716386748,0.692040897698295,0.401303401191728,-5.86154763686637,0.131615467757531,"AP2A2","adaptor related protein complex 2 alpha 2 subunit",TRUE
+"200615_s_at",0.725583196024696,0.20450595207877,1.30732812625926,-5.13985353422917,0.542483395021188,"AP2B1","adaptor related protein complex 2 beta 1 subunit",TRUE
+"200612_s_at",0.7717895132349,0.281709206471213,1.10336367335841,-5.36350934006117,0.424027827032702,"AP2B1","adaptor related protein complex 2 beta 1 subunit",TRUE
+"200613_at",0.846898808963473,0.445528081155544,0.776736227871915,-5.65002518595797,0.22332396268617,"AP2M1","adaptor related protein complex 2 mu 1 subunit",TRUE
+"202120_x_at",0.498396792791655,0.0312034117349995,-2.30048511235902,-3.64613020105816,-0.672942408709282,"AP2S1","adaptor related protein complex 2 sigma 1 subunit",TRUE
+"208074_s_at",0.535243600695458,0.0428381026964968,-2.14872411571716,-3.91089431747585,-0.585925622056415,"AP2S1","adaptor related protein complex 2 sigma 1 subunit",TRUE
+"211047_x_at",0.586168493787511,0.0660196723318425,-1.93374734730442,-4.26602545139975,-0.510250105218999,"AP2S1","adaptor related protein complex 2 sigma 1 subunit",TRUE
+"203141_s_at",0.967926796644136,0.848766023562989,0.192936854665109,-5.92156898275205,0.0578401068239565,"AP3B1","adaptor related protein complex 3 beta 1 subunit",TRUE
+"203142_s_at",0.972513835925299,0.867338265521526,-0.16898937637828,-5.92578378395501,-0.0426587775055314,"AP3B1","adaptor related protein complex 3 beta 1 subunit",TRUE
+"1570032_at",0.79943091106207,0.334264721857734,0.98707170758672,-5.47595779174123,0.689637285676862,"AP3B2","adaptor related protein complex 3 beta 2 subunit",TRUE
+"205678_at",0.94333312187812,0.745692875114881,0.328399750506159,-5.88729155709888,0.332220403668189,"AP3B2","adaptor related protein complex 3 beta 2 subunit",TRUE
+"206592_s_at",0.597346378847428,0.0734514806582763,-1.8790838996678,-4.35227184471965,-0.460621435758492,"AP3D1","adaptor related protein complex 3 delta 1 subunit",TRUE
+"208710_s_at",0.787781415608703,0.313593685312437,-1.031154248096,-5.43465838578117,-0.330009409192041,"AP3D1","adaptor related protein complex 3 delta 1 subunit",TRUE
+"210974_s_at",0.813163231957058,0.363012129229225,-0.92877925495899,-5.52804116173489,-0.290474291137915,"AP3D1","adaptor related protein complex 3 delta 1 subunit",TRUE
+"222516_at",0.984161165881616,0.922720341580008,-0.098118616587097,-5.93499548354334,-0.0359371605345036,"AP3M1","adaptor related protein complex 3 mu 1 subunit",TRUE
+"222517_at",0.997293485734839,0.986312136409139,-0.0173506980688978,-5.93953685305331,-0.00624224750738644,"AP3M1","adaptor related protein complex 3 mu 1 subunit",TRUE
+"203410_at",0.761955282232063,0.261357281444538,-1.1526036534081,-5.31254290187764,-0.533735738133375,"AP3M2","adaptor related protein complex 3 mu 2 subunit",TRUE
+"1569053_at",0.999500506744552,0.998528832407826,0.00186475131887989,-5.93968178708585,0.000801945136192472,"AP3M2","adaptor related protein complex 3 mu 2 subunit",TRUE
+"202442_at",0.740391616899638,0.228976348425349,1.23716949211751,-5.22047956780629,0.459142820050282,"AP3S1","adaptor related protein complex 3 sigma 1 subunit",TRUE
+"236221_at",0.741734366005262,0.232230100883098,1.2282794859857,-5.23042343385563,1.03523513087925,"AP4B1","adaptor related protein complex 4 beta 1 subunit",TRUE
+"231962_at",0.776074974591224,0.2935129967707,-1.07598085595217,-5.39099687421871,-0.384035229231771,"AP4B1","adaptor related protein complex 4 beta 1 subunit",TRUE
+"231714_s_at",0.869487815945782,0.506805100720403,-0.674765854917116,-5.72031966432971,-0.316527001870487,"AP4B1","adaptor related protein complex 4 beta 1 subunit",TRUE
+"220228_at",0.743474458360704,0.233815292895887,1.22398258145513,-5.23520752027527,1.00095309187861,"AP4E1","adaptor related protein complex 4 epsilon 1 subunit",TRUE
+"228164_at",0.784925710185113,0.309946633477576,-1.03914126171439,-5.42700125300955,-0.399476325249095,"AP4E1","adaptor related protein complex 4 epsilon 1 subunit",TRUE
+"220229_s_at",0.861665593344139,0.483722874231654,0.712283620053426,-5.6955488435167,0.404166918393996,"AP4E1","adaptor related protein complex 4 epsilon 1 subunit",TRUE
+"241174_at",0.969882914559333,0.856711464971747,0.182678518652995,-5.9234425410406,0.0617731991076251,"AP4E1","adaptor related protein complex 4 epsilon 1 subunit",TRUE
+"209837_at",0.740476003158683,0.229412645560894,-1.23597187657302,-5.22182275683942,-0.522899967560651,"AP4M1","adaptor related protein complex 4 mu 1 subunit",TRUE
+"235647_at",0.632949074657601,0.103947341357464,-1.69571978807897,-4.6285145318892,-0.768339943534974,"AP4S1","adaptor related protein complex 4 sigma 1 subunit",TRUE
+"210277_at",0.741260241503758,0.231875151539804,-1.22924467618857,-5.2293468196419,-0.543544174500712,"AP4S1","adaptor related protein complex 4 sigma 1 subunit",TRUE
+"210278_s_at",0.813660971341375,0.364566707131909,-0.925717238849171,-5.53069663128624,-0.43734199289626,"AP4S1","adaptor related protein complex 4 sigma 1 subunit",TRUE
+"210952_at",0.831875452294783,0.407216400864304,0.844866129783083,-5.59787306963046,0.560306927339927,"AP4S1","adaptor related protein complex 4 sigma 1 subunit",TRUE
+"231858_x_at",0.942961933269639,0.744150092512317,0.330469096699004,-5.88663093846199,0.0809675528343465,"AP5B1","adaptor related protein complex 5 beta 1 subunit",TRUE
+"222531_s_at",0.296090407530139,0.00530583200277598,-3.09106902661466,-2.12276798165869,-0.981858688235315,"AP5M1","adaptor related protein complex 5 mu 1 subunit",TRUE
+"218139_s_at",0.322131160460075,0.00728219687843902,-2.95500807019766,-2.39868066346087,-0.973269395754507,"AP5M1","adaptor related protein complex 5 mu 1 subunit",TRUE
+"232156_at",0.767011398042819,0.268630813514597,-1.13469335520339,-5.33130849795296,-0.503647840006166,"AP5M1","adaptor related protein complex 5 mu 1 subunit",TRUE
+"236004_at",0.904957976522052,0.610517374787974,-0.516652650265853,-5.81050140450561,-0.173713388501226,"AP5M1","adaptor related protein complex 5 mu 1 subunit",TRUE
+"1555448_at",0.954724542854807,0.794252073000007,-0.263957686720003,-5.90580487113591,-0.0896055200248362,"AP5M1","adaptor related protein complex 5 mu 1 subunit",TRUE
+"219706_at",0.819780516863333,0.377571076265251,-0.900436810566541,-5.55231155248807,-0.321145490669206,"AP5S1","adaptor related protein complex 5 sigma 1 subunit",TRUE
+"211553_x_at",0.936765251273636,0.717475659119063,-0.366490417063415,-5.87447439128786,-0.12600157658716,"APAF1","apoptotic peptidase activating factor 1",TRUE
+"204859_s_at",0.990810941805126,0.953741620649038,0.0586690746601811,-5.93800711912812,0.0228938378071923,"APAF1","apoptotic peptidase activating factor 1",TRUE
+"211554_s_at",0.995810088048184,0.979818844201704,-0.0255831522396791,-5.93936470408892,-0.0130899243086642,"APAF1","apoptotic peptidase activating factor 1",TRUE
+"228101_at",0.800342373547779,0.336006392802388,-0.983444763336382,-5.4792828027494,-1.00841461000343,"APBA1","amyloid beta precursor protein binding family A member 1",TRUE
+"206679_at",0.899808883319249,0.592082134961405,0.543692642576351,-5.79672339670251,0.282423496200916,"APBA1","amyloid beta precursor protein binding family A member 1",TRUE
+"209870_s_at",0.854163696308241,0.463804370855859,0.745501698610937,-5.6725529569957,0.827659656745203,"APBA2","amyloid beta precursor protein binding family A member 2",TRUE
+"209871_s_at",0.855449962008039,0.468660455070548,-0.737326940932266,-5.67830439336939,-0.657535688545082,"APBA2","amyloid beta precursor protein binding family A member 2",TRUE
+"215148_s_at",0.921312278448293,0.664521743232549,0.439548095240471,-5.84601725843901,0.1448177326933,"APBA3","amyloid beta precursor protein binding family A member 3",TRUE
+"205146_x_at",0.96413799660135,0.835286486017609,0.210389450993239,-5.91814722148119,0.108352930224043,"APBA3","amyloid beta precursor protein binding family A member 3",TRUE
+"202652_at",0.918409982899324,0.653555747512966,0.454972390573057,-5.83936131015998,0.362734763892431,"APBB1","amyloid beta precursor protein binding family B member 1",TRUE
+"1554571_at",0.737488397392592,0.22378054066284,1.25156712470814,-5.20424429212843,0.995391183569478,"APBB1IP","amyloid beta precursor protein binding family B member 1 interacting protein",TRUE
+"219994_at",0.876380843707269,0.525091176204964,-0.645721755644671,-5.73861463197181,-0.447798837803267,"APBB1IP","amyloid beta precursor protein binding family B member 1 interacting protein",TRUE
+"230925_at",0.948668195792872,0.766519081536191,-0.30060393883157,-5.8957667124324,-0.381729975916229,"APBB1IP","amyloid beta precursor protein binding family B member 1 interacting protein",TRUE
+"216750_at",0.740610299769501,0.230413220743849,1.23323186916744,-5.22489160267968,0.340024803278125,"APBB2","amyloid beta precursor protein binding family B member 2",TRUE
+"212985_at",0.819030260228921,0.375358387026372,-0.904697100436956,-5.54870768056138,-0.587790830553709,"APBB2","amyloid beta precursor protein binding family B member 2",TRUE
+"212970_at",0.887780176248324,0.552994341175986,-0.602444934410459,-5.7644382788372,-0.275894622902365,"APBB2","amyloid beta precursor protein binding family B member 2",TRUE
+"216747_at",0.921729477898827,0.666511141073763,0.436761576691483,-5.8471956846853,0.19455827028112,"APBB2","amyloid beta precursor protein binding family B member 2",TRUE
+"40148_at",0.930899509890345,0.694526800319103,-0.397879270528842,-5.86287030374894,-0.241245065044916,"APBB2","amyloid beta precursor protein binding family B member 2",TRUE
+"213419_at",0.951893068371814,0.779627958604663,-0.283232664238466,-5.90068627075497,-0.221301546820495,"APBB2","amyloid beta precursor protein binding family B member 2",TRUE
+"212972_x_at",0.968066640321622,0.850210785239703,-0.191069983566566,-5.92191753464362,-0.0576971804988684,"APBB2","amyloid beta precursor protein binding family B member 2",TRUE
+"203527_s_at",0.611201850820302,0.0834610520022748,-1.81263700932057,-4.45475127157196,-1.35403415236711,"APC","APC, WNT signaling pathway regulator",TRUE
+"203525_s_at",0.715493644680006,0.191228761170629,-1.34816077248908,-5.09119714312021,-0.52976131740526,"APC","APC, WNT signaling pathway regulator",TRUE
+"215310_at",0.82153774281298,0.38394734216381,-0.888251125523115,-5.56253279617404,-0.721570281694587,"APC","APC, WNT signaling pathway regulator",TRUE
+"216933_x_at",0.95168059103032,0.778281227176826,-0.285013102030826,-5.9001954065781,-0.145871443457535,"APC","APC, WNT signaling pathway regulator",TRUE
+"203526_s_at",0.954806384662532,0.794458287287656,-0.263686637257842,-5.90587429683625,-0.0998232087936266,"APC","APC, WNT signaling pathway regulator",TRUE
+"205320_at",0.774230543658252,0.289863885345375,-1.08436008708986,-5.38265098775552,-0.549140667151687,"APC2","APC2, WNT signaling pathway regulator",TRUE
+"217174_s_at",0.975398143273847,0.882096245709258,0.150032659796269,-5.92872573107859,0.115971163055911,"APC2","APC2, WNT signaling pathway regulator",TRUE
+"225016_at",0.913782990161554,0.638483631598064,0.476357534317983,-5.8297611098005,0.618016785084327,"APCDD1","APC down-regulated 1",TRUE
+"235548_at",0.861659105448003,0.482507038181389,0.714288062175049,-5.69418947993966,0.523392530493877,"APCDD1L","APC down-regulated 1 like",TRUE
+"1556901_s_at",0.77938352158119,0.300648886212508,1.05980839550349,-5.4069411898439,0.880518698719832,"APCDD1L-AS1","APCDD1L antisense RNA 1 (head to head)",TRUE
+"1556900_at",0.856874648266698,0.471500266334288,0.732569610138002,-5.68162376685934,0.400861171622277,"APCDD1L-AS1","APCDD1L antisense RNA 1 (head to head)",TRUE
+"1559433_at",0.901897260897152,0.600011174538144,0.532013560655371,-5.80275827194496,0.534876299702403,"APCDD1L-AS1","APCDD1L antisense RNA 1 (head to head)",TRUE
+"206350_at",0.819780516863333,0.377555182604953,0.900467353296246,-5.55228577168301,0.394621414121927,"APCS","amyloid P component, serum",TRUE
+"201284_s_at",0.62986301194198,0.100994385925641,-1.7112828073093,-4.60588104080394,-0.653496006231732,"APEH","acylaminoacyl-peptide hydrolase",TRUE
+"242015_x_at",0.833762648920706,0.411408534002587,-0.837220435728763,-5.60393012017799,-0.339679546749045,"APEH","acylaminoacyl-peptide hydrolase",TRUE
+"1559280_a_at",0.940044918888428,0.730977087898539,0.348199284431738,-5.88080252826632,0.330266779129317,"APELA","apelin receptor early endogenous ligand",TRUE
+"210027_s_at",0.986106775020837,0.931801013711504,0.0865571306196419,-5.93603499584489,0.03135362747296,"APEX1","apurinic/apyrimidinic endodeoxyribonuclease 1",TRUE
+"238813_at",0.687659256779784,0.156646851474923,-1.46618719630042,-4.9435998571716,-0.77782758290365,"APEX2","apurinic/apyrimidinic endodeoxyribonuclease 2",TRUE
+"204408_at",0.991328040460654,0.959311117713533,0.0515983285490868,-5.93838681315002,0.0171568785808116,"APEX2","apurinic/apyrimidinic endodeoxyribonuclease 2",TRUE
+"237327_at",0.68041487556515,0.14813479798703,-1.49842941155631,-4.9015277579546,-0.425299961910116,"APH1A","aph-1 homolog A, gamma-secretase subunit",TRUE
+"218389_s_at",0.886685015168353,0.549707622882205,-0.607481113267994,-5.76152190596771,-0.239123375405786,"APH1A","aph-1 homolog A, gamma-secretase subunit",TRUE
+"1554417_s_at",0.952613441433926,0.782664594089386,-0.279221518104123,-5.90178095293218,-0.145613463332207,"APH1A","aph-1 homolog A, gamma-secretase subunit",TRUE
+"226358_at",0.675158868445887,0.141334273009364,-1.52529374445974,-4.86591315620391,-0.842407466463734,"APH1B","aph-1 homolog B, gamma-secretase subunit",TRUE
+"221036_s_at",0.962741248200658,0.830410247664203,-0.216719157401974,-5.91683334898885,-0.121360008914012,"APH1B","aph-1 homolog B, gamma-secretase subunit",TRUE
+"201687_s_at",0.708894565317004,0.181087789865837,-1.38087662980919,-5.05130996201573,-0.367739812766549,"API5","apoptosis inhibitor 5",TRUE
+"214959_s_at",0.756601922352523,0.252043206887206,-1.17608487618274,-5.28754972080627,-0.38859003887843,"API5","apoptosis inhibitor 5",TRUE
+"214960_at",0.980001024522674,0.90497422247573,-0.12075404493333,-5.93258384518745,-0.0444750313164395,"API5","apoptosis inhibitor 5",TRUE
+"233078_at",0.99514093116831,0.977813557295932,0.028125873853502,-5.93929818960612,0.0130647122267851,"API5","apoptosis inhibitor 5",TRUE
+"201686_x_at",0.997033004876606,0.984705719804881,0.0193872399666943,-5.93950041238798,0.00596095939769725,"API5","apoptosis inhibitor 5",TRUE
+"232630_at",0.866064868550751,0.496686420087377,0.691090074810453,-5.70969894804968,0.596351414970638,"APIP","APAF1 interacting protein",TRUE
+"218698_at",0.92218645993289,0.668022464402095,0.434647037222955,-5.84808501887724,0.203613944214347,"APIP","APAF1 interacting protein",TRUE
+"213454_at",0.852994610926182,0.459298790044203,-0.753132103281674,-5.66713029318858,-0.239124505374239,"APITD1-CORT///APITD1","APITD1-CORT readthrough///apoptosis-inducing, TAF9-like domain 1",TRUE
+"241379_at",0.812302873476553,0.359026935854902,0.936669110859212,-5.52116170372693,1.09371122448859,"APLF","aprataxin and PNKP like factor",TRUE
+"1555100_at",0.852144204264284,0.457765476423343,0.755739042014727,-5.66526565117222,0.244282397023674,"APLF","aprataxin and PNKP like factor",TRUE
+"244166_at",0.885929137203218,0.548005500114574,0.610095475811989,-5.75999873175281,0.602416644119026,"APLN","apelin",TRUE
+"222856_at",0.902960767180391,0.602649479783928,-0.528144091754101,-5.80472960526369,-0.389601702279138,"APLN","apelin",TRUE
+"213592_at",0.774230543658252,0.287190026819212,-1.09054820131574,-5.37645043238078,-0.436130265867695,"APLNR","apelin receptor",TRUE
+"209462_at",0.179861672609328,0.00163495658503587,-3.5853343021682,-1.08983415505325,-4.02408055234763,"APLP1","amyloid beta precursor like protein 1",TRUE
+"208701_at",0.778686132916778,0.299512122834286,1.06236621605631,-5.40443384974192,0.423317914376934,"APLP2","amyloid beta precursor like protein 2",TRUE
+"211404_s_at",0.908882763411412,0.621482372411312,0.500754030961131,-5.81828267599958,0.208622250567956,"APLP2","amyloid beta precursor like protein 2",TRUE
+"208703_s_at",0.93565329131222,0.713522349309276,0.371870100227753,-5.87255233766333,0.142790375612833,"APLP2","amyloid beta precursor like protein 2",TRUE
+"228520_s_at",0.939452234779565,0.728851760870321,0.351070403947549,-5.87983038805862,0.161235158863816,"APLP2","amyloid beta precursor like protein 2",TRUE
+"208702_x_at",0.946727564264032,0.758388591542616,0.311425375641258,-5.89255537861749,0.121080840972702,"APLP2","amyloid beta precursor like protein 2",TRUE
+"208704_x_at",0.947926063538122,0.762820959069853,0.305521407318427,-5.8943213715017,0.125727656186315,"APLP2","amyloid beta precursor like protein 2",TRUE
+"208248_x_at",0.966379620296737,0.843397098156368,0.199880602829302,-5.92024292358523,0.068492071754342,"APLP2","amyloid beta precursor like protein 2",TRUE
+"214875_x_at",0.991059530537351,0.958273497508103,0.0529154222406294,-5.93831977559115,0.0221254912510513,"APLP2","amyloid beta precursor like protein 2",TRUE
+"227857_at",0.789595899448337,0.316892442360925,1.02398608168226,-5.44148510616702,0.343927843998174,"APMAP","adipocyte plasma membrane associated protein",TRUE
+"228309_at",0.897011777275924,0.582455627924776,0.557975747161214,-5.7891699194201,0.161641619392066,"APMAP","adipocyte plasma membrane associated protein",TRUE
+"206656_s_at",0.89748872632674,0.584258633405195,-0.555291724059921,-5.79060384783406,-0.28234055893579,"APMAP","adipocyte plasma membrane associated protein",TRUE
+"231694_at",0.698633641632588,0.169908212762479,1.41867370943267,-5.00424226954044,0.923306626790771,"APOA1","apolipoprotein A1",TRUE
+"217073_x_at",0.773234064853267,0.284362003052032,-1.09713849358536,-5.36981233910255,-0.681624716329154,"APOA1","apolipoprotein A1",TRUE
+"204450_x_at",0.971216837324271,0.862503765558996,-0.17521278338244,-5.92474192905164,-0.110671303097604,"APOA1","apolipoprotein A1",TRUE
+"219465_at",0.617775129514679,0.0887166931358145,1.78047320109286,-4.50340121072381,1.0294363057548,"APOA2","apolipoprotein A2",TRUE
+"219466_s_at",0.965380895563592,0.838557277132061,-0.206148667476672,-5.91900579774546,-0.15611900226527,"APOA2","apolipoprotein A2",TRUE
+"206894_at",0.869850840015332,0.507613017906298,-0.6734704217009,-5.72115208776954,-0.447342879957422,"APOA4","apolipoprotein A4",TRUE
+"224244_s_at",0.823773334423331,0.391009902053223,-0.87490737534809,-5.57357733309216,-0.352549909287214,"APOA5","apolipoprotein A5",TRUE
+"224243_at",0.830635993561085,0.403485650645151,-0.851712641906593,-5.59240554573218,-0.411144248584542,"APOA5","apolipoprotein A5",TRUE
+"223579_s_at",0.747353667214475,0.239139504488656,1.20970994202503,-5.25099425143905,0.880300859574026,"APOB","apolipoprotein B",TRUE
+"205108_s_at",0.921729477898827,0.666187554634944,0.437214579350284,-5.84700460943421,0.267588491451931,"APOB","apolipoprotein B",TRUE
+"207158_at",0.985570676309952,0.930393139223811,-0.0883488001627748,-5.93588241935516,-0.0318874054167475,"APOBEC1","apolipoprotein B mRNA editing enzyme catalytic subunit 1",TRUE
+"206160_at",0.968451827985008,0.851824663353718,-0.188985407001176,-5.92230274208854,-0.0980172787738303,"APOBEC2","apolipoprotein B mRNA editing enzyme catalytic subunit 2",TRUE
+"210873_x_at",0.829626140494984,0.401083670424184,-0.856142110318394,-5.58884632399069,-0.536410879433058,"APOBEC3A_B///APOBEC3A","APOBEC3A and APOBEC3B deletion hybrid///apolipoprotein B mRNA editing enzyme catalytic subunit 3A",TRUE
+"206632_s_at",0.384135218769668,0.0123851393495081,-2.72253370630414,-2.85857938455649,-1.71834400785888,"APOBEC3B","apolipoprotein B mRNA editing enzyme catalytic subunit 3B",TRUE
+"209584_x_at",0.130547951137661,0.000794417876786796,3.88260377369396,-0.453592345420629,3.34792465077181,"APOBEC3C","apolipoprotein B mRNA editing enzyme catalytic subunit 3C",TRUE
+"1553831_at",0.806649582904638,0.347806802584314,-0.959204315779229,-5.50121857036613,-0.258769359290315,"APOBEC3D","apolipoprotein B mRNA editing enzyme catalytic subunit 3D",TRUE
+"214994_at",0.774230543658252,0.289959250235533,1.0841401445486,-5.38287079344947,0.786319627080035,"APOBEC3F","apolipoprotein B mRNA editing enzyme catalytic subunit 3F",TRUE
+"243912_x_at",0.81031378318664,0.354019867402671,0.94666594615067,-5.51236836999642,0.473195202191552,"APOBEC3F","apolipoprotein B mRNA editing enzyme catalytic subunit 3F",TRUE
+"214995_s_at",0.327689791987697,0.00758633259657796,2.93729913442087,-2.43425158366038,2.99532194301969,"APOBEC3F///APOBEC3G","apolipoprotein B mRNA editing enzyme catalytic subunit 3F///apolipoprotein B mRNA editing enzyme catalytic subunit 3G",TRUE
+"204205_at",0.0550822163069259,0.000101752242286228,4.72198405305596,1.3567307278429,4.72629752599307,"APOBEC3G","apolipoprotein B mRNA editing enzyme catalytic subunit 3G",TRUE
+"215579_at",0.61760967235709,0.0878368883522247,1.78574088311019,-4.49547687298765,0.767450945146704,"APOBEC3G","apolipoprotein B mRNA editing enzyme catalytic subunit 3G",TRUE
+"1554545_at",0.986285942607238,0.93296246302156,0.08507928199935,-5.93615849684768,0.0258539645198264,"APOBEC4","apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4",TRUE
+"220023_at",0.772420279152863,0.282774706203849,-1.10085824010139,-5.36604990494379,-0.71816034319664,"APOBR","apolipoprotein B receptor",TRUE
+"204416_x_at",0.255533790235106,0.0036548225690691,3.24930058250368,-1.79669378193931,3.07509724228845,"APOC1","apolipoprotein C1",TRUE
+"213553_x_at",0.870433264908839,0.508716481609297,0.671702969911253,-5.72228535272264,0.441972133875507,"APOC1","apolipoprotein C1",TRUE
+"231561_s_at",0.737037362362438,0.222359551491964,1.25554909466715,-5.19972560606779,0.631738005830885,"APOC2","apolipoprotein C2",TRUE
+"231562_at",0.962795886672571,0.830751720420635,0.216275609395808,-5.91692668051627,0.092101617247792,"APOC2","apolipoprotein C2",TRUE
+"231587_at",0.773234064853267,0.284334046205703,-1.09720387883,-5.36974630129507,-0.768306714503852,"APOC3","apolipoprotein C3",TRUE
+"205820_s_at",0.773657212801073,0.285181297975177,1.09522439406872,-5.37174399018662,0.43303966399363,"APOC3","apolipoprotein C3",TRUE
+"206738_at",0.702809964629668,0.174398823284892,1.40325974178445,-5.02356350851687,0.381885237682585,"APOC4-APOC2///APOC4///APOC2","APOC4-APOC2 readthrough (NMD candidate)///apolipoprotein C4///apolipoprotein C2",TRUE
+"204561_x_at",0.848268984089208,0.448051329073647,0.772378474606827,-5.6532206225251,0.302564193298711,"APOC4-APOC2///APOC4///APOC2","APOC4-APOC2 readthrough (NMD candidate)///apolipoprotein C4///apolipoprotein C2",TRUE
+"201525_at",0.766354920892204,0.266650864472854,-1.1395330546799,-5.32626320746007,-1.43320408063491,"APOD","apolipoprotein D",TRUE
+"203382_s_at",0.443919401133943,0.0207040598608423,2.49112488055815,-3.29895668031984,3.31565985901212,"APOE","apolipoprotein E",TRUE
+"203381_s_at",0.631294544151106,0.102345473549959,1.70411479085021,-4.61632485794394,1.99981589660737,"APOE","apolipoprotein E",TRUE
+"212884_x_at",0.758081075834994,0.254824575632409,1.16900638454009,-5.29513048359324,0.615404788027034,"APOE","apolipoprotein E",TRUE
+"207262_at",0.721317419960934,0.197565058497496,-1.32840658775559,-5.11489361590559,-1.26587266068503,"APOF","apolipoprotein F",TRUE
+"205216_s_at",0.748184017928985,0.240226997834143,1.2068242520014,-5.25416656220936,1.02300520722966,"APOH","apolipoprotein H",TRUE
+"231359_at",0.892780783477555,0.565860715056239,0.58287863571586,-5.77554614494338,0.239793150352891,"APOH","apolipoprotein H",TRUE
+"209546_s_at",0.623667408398064,0.0949266916675452,1.7445184723567,-4.55702976647663,1.51268152651936,"APOL1","apolipoprotein L1",TRUE
+"221013_s_at",0.544577979658206,0.0466642615212144,2.10697755297653,-3.98175909500563,0.849521344170208,"APOL2","apolipoprotein L2",TRUE
+"221653_x_at",0.740610299769501,0.230262377956549,1.23364436229636,-5.22442998014038,1.02117029920043,"APOL2","apolipoprotein L2",TRUE
+"221087_s_at",0.632509555769443,0.10349209850779,1.69809436424859,-4.62507120139762,1.89146173376487,"APOL3","apolipoprotein L3",TRUE
+"223801_s_at",0.80056683899707,0.336538239186258,0.98233979850206,-5.48029356777188,0.718477145486058,"APOL4","apolipoprotein L4",TRUE
+"1555600_s_at",0.849935057946582,0.451595073288775,0.766283359488166,-5.65766155056973,0.528747747653123,"APOL4","apolipoprotein L4",TRUE
+"224491_at",0.99739139970986,0.986830794389548,0.0166931835605381,-5.93954775549068,0.00908857768161475,"APOL4","apolipoprotein L4",TRUE
+"220478_at",0.96350209729653,0.833513272537242,-0.212690178007487,-5.91767413928096,-0.0706095541590139,"APOL5","apolipoprotein L5",TRUE
+"1557236_at",0.482262518773694,0.0274435721781711,2.360804118142,-3.53795296050201,3.98318365218289,"APOL6","apolipoprotein L6",TRUE
+"241869_at",0.52248118659945,0.0382665120013278,2.20326869599574,-3.8169992310336,3.55664387874159,"APOL6","apolipoprotein L6",TRUE
+"1557116_at",0.597654932724127,0.0749686425054204,1.86852398284976,-4.3687331705832,1.40485556355899,"APOL6","apolipoprotein L6",TRUE
+"219716_at",0.614110383129587,0.0850375804421418,1.80280946450943,-4.46968312252462,2.0806270146247,"APOL6","apolipoprotein L6",TRUE
+"221031_s_at",0.554642754132296,0.0511486325621221,2.06179918996387,-4.0574435831567,1.00836465380939,"APOLD1","apolipoprotein L domain containing 1",TRUE
+"220890_s_at",0.380731642340006,0.0119101568827318,2.73986205949935,-2.82485994020311,1.08551873770539,"APOLD1///DDX47","apolipoprotein L domain containing 1///DEAD-box helicase 47",TRUE
+"205682_x_at",0.687277721925286,0.155917402399361,1.46889368025917,-4.940096650104,0.435153720226657,"APOM","apolipoprotein M",TRUE
+"214910_s_at",0.73223722457785,0.216153646039834,1.27317167368812,-5.17958023982971,0.556036663489159,"APOM","apolipoprotein M",TRUE
+"221620_s_at",0.73223722457785,0.216191934671155,-1.27306176324296,-5.17970662843891,-0.434989883569154,"APOO","apolipoprotein O",TRUE
+"222269_at",0.786851686785014,0.312759143353864,-1.03297609203846,-5.4329164762163,-0.422537313172676,"APOOL","apolipoprotein O like",TRUE
+"213282_at",0.843461221384182,0.438193395013001,-0.789489716332468,-5.64057599300526,-0.288364088164208,"APOOL","apolipoprotein O like",TRUE
+"213289_at",0.853460708803218,0.46207515436751,-0.748424950777261,-5.67048168376181,-0.252422169458903,"APOOL","apolipoprotein O like",TRUE
+"235433_at",0.912252515563073,0.632549213889612,-0.484839284721761,-5.82583401543461,-0.157445475608027,"APOOL","apolipoprotein O like",TRUE
+"232814_x_at",0.783598827774051,0.306164765536858,-1.04749389515536,-5.4189367163194,-0.509992312853282,"APOPT1","apoptogenic 1, mitochondrial",TRUE
+"225948_at",0.979588787486838,0.901516500988082,-0.12517157106549,-5.93205509363862,-0.0386974990740789,"APOPT1","apoptogenic 1, mitochondrial",TRUE
+"200602_at",0.774230543658252,0.287107916956883,1.09073888426948,-5.37625886668844,0.491168241645552,"APP","amyloid beta precursor protein",TRUE
+"211277_x_at",0.80056683899707,0.336489871669503,0.982440237269682,-5.4802017343016,0.398807371534758,"APP","amyloid beta precursor protein",TRUE
+"214953_s_at",0.84231658612216,0.435953869863818,0.793409847124587,-5.63764241117517,0.385359791712077,"APP","amyloid beta precursor protein",TRUE
+"202630_at",0.703948341108555,0.175773746069919,-1.39860375157163,-5.02936552360898,-1.03594124877533,"APPBP2","amyloid beta precursor protein binding protein 2",TRUE
+"202629_at",0.704136697708699,0.175974796959066,-1.39792535542064,-5.03020957126817,-1.00731286572928,"APPBP2","amyloid beta precursor protein binding protein 2",TRUE
+"202631_s_at",0.801547748171611,0.338391480072602,-0.978498852859439,-5.4837990149705,-0.810477554769911,"APPBP2","amyloid beta precursor protein binding protein 2",TRUE
+"215402_at",0.983567332578112,0.919994519649533,0.101591727210098,-5.934657811044,0.0944073603681801,"APPBP2","amyloid beta precursor protein binding protein 2",TRUE
+"218158_s_at",0.841967750949524,0.434974322694472,-0.795128374724915,-5.63635206161464,-0.27854949703525,"APPL1","adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1",TRUE
+"222538_s_at",0.973433731874338,0.87155668490184,0.163564628602107,-5.92666128658894,0.0532201133287078,"APPL1","adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1",TRUE
+"218218_at",0.680708651141727,0.148521327781534,-1.49693301739135,-4.90349665845269,-0.596081458875426,"APPL2","adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2",TRUE
+"203219_s_at",0.45647012846614,0.0222958198888619,-2.45712997141992,-3.36196944185608,-0.987912798821052,"APRT","adenine phosphoribosyltransferase",TRUE
+"213892_s_at",0.595925222489779,0.0722554599920358,-1.8875437668871,-4.33903710602843,-0.730642856988521,"APRT","adenine phosphoribosyltransferase",TRUE
+"238126_at",0.94214388523134,0.739660009822984,0.336500100750827,-5.88468218012897,0.281007559730155,"APTR","Alu-mediated CDKN1A/p21 transcriptional regulator (non-protein coding)",TRUE
+"227431_at",0.948109877411639,0.764305805115921,0.303546060360845,-5.89490475821021,0.129636967166265,"APTR","Alu-mediated CDKN1A/p21 transcriptional regulator (non-protein coding)",TRUE
+"218527_at",0.809109571194383,0.352284913333972,-0.95015210076298,-5.50928177841417,-0.293083545000005,"APTX","aprataxin",TRUE
+"222658_s_at",0.867026157046741,0.498608244418043,-0.687975244884926,-5.71174421925067,-0.173741249824683,"APTX","aprataxin",TRUE
+"243132_at",0.929126743655924,0.688479943163715,0.406216860792945,-5.85963018169418,0.194721286158326,"APTX","aprataxin",TRUE
+"209047_at",0.916392138713508,0.646924742052162,0.464353706606048,-5.83520301781728,0.3909167978104,"AQP1","aquaporin 1 (Colton blood group)",TRUE
+"207542_s_at",0.969882914559333,0.85658000722684,0.182848077159992,-5.9234124022989,0.144204214161526,"AQP1","aquaporin 1 (Colton blood group)",TRUE
+"1555338_s_at",0.929275354134865,0.689133946204888,-0.40531369796867,-5.85998435979851,-0.239588657653957,"AQP10","aquaporin 10",TRUE
+"229526_at",0.806221445484273,0.347037434119982,-0.960767496317927,-5.49981909391737,-1.03762235734083,"AQP11","aquaporin 11",TRUE
+"1559575_a_at",0.834881450121645,0.41360793784446,0.833228889788828,-5.60707185010889,0.520340560003522,"AQP12B///AQP12A","aquaporin 12B///aquaporin 12A",TRUE
+"1554344_s_at",0.896115372949367,0.577232795371842,-0.565774189782213,-5.78496557889647,-0.233072520345839,"AQP12B///AQP12A","aquaporin 12B///aquaporin 12A",TRUE
+"236630_at",0.6708432030569,0.136729924448754,1.54409119591388,-4.84069369488899,0.845934347547985,"AQP2","aquaporin 2",TRUE
+"206672_at",0.821424121108148,0.383405610082604,0.889281247726951,-5.56167372805486,0.228422428065914,"AQP2","aquaporin 2",TRUE
+"240285_at",0.863918945062466,0.490282607345594,0.701519126106756,-5.702786804171,0.56793889073121,"AQP2","aquaporin 2",TRUE
+"39248_at",0.822850703882235,0.388502058346399,0.879627491958261,-5.56968824796232,1.34726972669162,"AQP3","aquaporin 3 (Gill blood group)",TRUE
+"203747_at",0.839554522305768,0.428276455082399,0.806943818877441,-5.62740944481942,0.596605160405689,"AQP3","aquaporin 3 (Gill blood group)",TRUE
+"39249_at",0.856257656023992,0.469931327440455,0.735195841773407,-5.67979386500705,0.812183477272159,"AQP3","aquaporin 3 (Gill blood group)",TRUE
+"226228_at",0.675118548055585,0.141295753458415,1.52544889948405,-4.86570599819489,1.67239727604465,"AQP4","aquaporin 4",TRUE
+"210906_x_at",0.732074070325545,0.215778722100722,1.27424871389252,-5.17834123307939,0.929484982633123,"AQP4","aquaporin 4",TRUE
+"210068_s_at",0.759046106067723,0.256680447280953,-1.1643151423098,-5.30013252634004,-0.772297336813192,"AQP4","aquaporin 4",TRUE
+"210066_s_at",0.853460708803218,0.461840331073484,-0.748822423853756,-5.67019946077745,-0.628443176547833,"AQP4","aquaporin 4",TRUE
+"210067_at",0.974435013896831,0.87493303524871,-0.159226378982882,-5.92734248897466,-0.108067012064543,"AQP4","aquaporin 4",TRUE
+"1553440_at",0.592488489935347,0.0695262358294602,1.90731716088159,-4.3079411511543,0.756185068209089,"AQP4-AS1","AQP4 antisense RNA 1",TRUE
+"1560751_at",0.948962238903406,0.769691839539078,0.296391084686195,-5.89698646208887,0.223318015373373,"AQP4-AS1","AQP4 antisense RNA 1",TRUE
+"213611_at",0.686950785936014,0.155457559659557,1.47060512071953,-4.93787870445407,0.690091540278582,"AQP5","aquaporin 5",TRUE
+"216219_at",0.930131991602783,0.691589498941526,-0.401925689496581,-5.86130606212894,-0.27185513002645,"AQP6","aquaporin 6",TRUE
+"208435_s_at",0.977957095232011,0.89356749165991,0.13533692236844,-5.93076632791538,0.0567317015621147,"AQP6","aquaporin 6",TRUE
+"206784_at",0.801560848966415,0.338471050233073,-0.978334262973641,-5.48394894869428,-0.595564560513576,"AQP8","aquaporin 8",TRUE
+"205568_at",0.64513208805899,0.115852476787595,1.63654436206944,-4.71314117564993,0.584847326770615,"AQP9","aquaporin 9",TRUE
+"228694_at",0.796526145641047,0.329324669056983,-0.997430567720629,-5.46640000569075,-0.498480204387182,"AQR","aquarius intron-binding spliceosomal factor",TRUE
+"212584_at",0.842397669245069,0.436269858660752,-0.792855980977818,-5.63805771963019,-0.239107488516961,"AQR","aquarius intron-binding spliceosomal factor",TRUE
+"239895_at",0.88113080359582,0.537718068671754,0.625988919534349,-5.75060326286245,0.488186155579753,"AQR","aquarius intron-binding spliceosomal factor",TRUE
+"212583_at",0.949613960042259,0.772258899141163,-0.292986496303795,-5.897959722243,-0.141000271232351,"AQR","aquarius intron-binding spliceosomal factor",TRUE
+"211110_s_at",0.303678178370857,0.00585972525251493,-3.04857756770524,-2.2094125119236,-2.93797107129849,"AR","androgen receptor",TRUE
+"226192_at",0.455234810916548,0.022147259784115,-2.46020560929318,-3.35628741258902,-4.20575839286762,"AR","androgen receptor",TRUE
+"226197_at",0.55937703282623,0.0536532812138588,-2.03808783570826,-4.09673776513655,-2.52784252687771,"AR","androgen receptor",TRUE
+"211621_at",0.632216562924782,0.103326951737692,-1.69895797341681,-4.6238179983598,-1.40848550353908,"AR","androgen receptor",TRUE
+"201895_at",0.938400005975956,0.726276324223402,0.354553617768815,-5.87864040732555,0.114250739052514,"ARAF","A-Raf proto-oncogene, serine/threonine kinase",TRUE
+"230652_at",0.966051687342135,0.841226374437141,-0.202690884234021,-5.91969296414664,-0.108100812948773,"ARAF","A-Raf proto-oncogene, serine/threonine kinase",TRUE
+"212516_at",0.769258076576208,0.275823614289429,1.11732854980636,-5.34925476988563,0.404040544863093,"ARAP1","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1",TRUE
+"242039_at",0.859675188316647,0.477820521322099,-0.722041929688741,-5.68889677424275,-0.487976108715148,"ARAP1","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1",TRUE
+"34206_at",0.892780783477555,0.566041483549883,0.5826053824319,-5.77569876064793,0.163142316774461,"ARAP1","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1",TRUE
+"213618_at",0.432506261584735,0.0194167520725955,2.52044689737701,-3.24424114120589,1.18276835152137,"ARAP2","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2",TRUE
+"1561407_at",0.676294804179428,0.142954253803923,1.51879974447716,-4.87456868392676,0.929334845917531,"ARAP2","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2",TRUE
+"242402_x_at",0.837548264373422,0.421523833393022,-0.818972782094449,-5.61817805792431,-0.373417573309095,"ARAP2","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2",TRUE
+"235806_at",0.520899183693116,0.0377990617469485,2.20917455577553,-3.80674584047229,1.84803530392497,"ARAP3","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3",TRUE
+"218950_at",0.547343369043481,0.0478515870869216,2.09464882838387,-4.00251752425799,2.23253064258263,"ARAP3","ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3",TRUE
+"210090_at",0.943988850936011,0.749606770894776,0.323156543582499,-5.8889470123164,0.320654868759349,"ARC","activity regulated cytoskeleton associated protein",TRUE
+"201176_s_at",0.83872852514497,0.424017426291576,0.814516830903214,-5.62161262709518,0.245240729380395,"ARCN1","archain 1",TRUE
+"205239_at",0.789795896476304,0.317912341362629,1.02178045103229,-5.44357702209235,1.50777373604571,"AREG","amphiregulin",TRUE
+"1557285_at",0.808266620412549,0.351167100927719,0.952404348629667,-5.50728214343783,1.09444341027836,"AREG","amphiregulin",TRUE
+"215564_at",0.919138643373719,0.65563583809516,0.452038112687174,-5.84064485871114,0.383041161468977,"AREG","amphiregulin",TRUE
+"202128_at",0.716472449896956,0.19248744541632,-1.34419621948924,-5.09597642549066,-0.385541810108091,"AREL1","apoptosis resistant E3 ubiquitin protein ligase 1",TRUE
+"244137_at",0.769847953580141,0.277714536926768,-1.11281848331286,-5.35387577715615,-0.867387576865214,"AREL1","apoptosis resistant E3 ubiquitin protein ligase 1",TRUE
+"1554989_at",0.998347572104896,0.993065343083634,-0.00879000931312411,-5.939645848245,-0.00614911160292131,"AREL1","apoptosis resistant E3 ubiquitin protein ligase 1",TRUE
+"232175_at",0.84051226748197,0.429648222902938,-0.804514657842702,-5.6292580957889,-0.595273865482983,"ARF1","ADP ribosylation factor 1",TRUE
+"200011_s_at",0.610660880283135,0.0832937619056344,-1.81368924042257,-4.45314904935426,-0.587269096127756,"ARF3","ADP ribosylation factor 3",TRUE
+"200734_s_at",0.710842845257879,0.18447869647383,-1.369779601703,-5.06492874459176,-0.453055636873724,"ARF3","ADP ribosylation factor 3",TRUE
+"211622_s_at",0.73826901296725,0.225116336948637,-1.24784146953041,-5.20846095654612,-0.455585702183107,"ARF3","ADP ribosylation factor 3",TRUE
+"201097_s_at",0.819287552962377,0.376226553686982,-0.903023571562431,-5.55012522965856,-0.287442352611313,"ARF4","ADP ribosylation factor 4",TRUE
+"201096_s_at",0.901910595357431,0.600111488004499,-0.531866285904738,-5.80283355865487,-0.186394099342873,"ARF4","ADP ribosylation factor 4",TRUE
+"201526_at",0.831875452294783,0.406966361542338,-0.845323736256762,-5.59750891565561,-0.243012517733094,"ARF5","ADP ribosylation factor 5",TRUE
+"203312_x_at",0.501591596209182,0.0322498975836998,-2.28488481614838,-3.67384393062018,-0.691346265902856,"ARF6","ADP ribosylation factor 6",TRUE
+"224788_at",0.571677937624457,0.0595749855159227,-1.98572809450713,-4.18243838646933,-0.823020821421862,"ARF6","ADP ribosylation factor 6",TRUE
+"203311_s_at",0.752235383514782,0.245444623154429,-1.1931142453938,-5.26914836895406,-0.667144519207483,"ARF6","ADP ribosylation factor 6",TRUE
+"214182_at",0.993952584307899,0.971615276830033,-0.0359866260950423,-5.93905273553343,-0.0177498235216511,"ARF6","ADP ribosylation factor 6",TRUE
+"217888_s_at",0.567293479905907,0.0574842408206589,-2.00366357326301,-4.15324988842241,-0.621111504657483,"ARFGAP1","ADP ribosylation factor GTPase activating protein 1",TRUE
+"234001_s_at",0.588984479037728,0.0676728885457392,-1.92113659061139,-4.28607468438641,-0.661740360070466,"ARFGAP1","ADP ribosylation factor GTPase activating protein 1",TRUE
+"211975_at",0.869082033398093,0.505803120999619,-0.676374065335643,-5.71928412591134,-0.208078936512361,"ARFGAP2","ADP ribosylation factor GTPase activating protein 2",TRUE
+"235734_at",0.930899509890345,0.694487025979192,0.39793401827899,-5.8628492436915,0.299736235615271,"ARFGAP2","ADP ribosylation factor GTPase activating protein 2",TRUE
+"202211_at",0.731054546207485,0.21404451921812,1.27924937036054,-5.17257686387335,0.436204310108462,"ARFGAP3","ADP ribosylation factor GTPase activating protein 3",TRUE
+"202955_s_at",0.744688669253745,0.236040947993268,-1.21798668299462,-5.24185900712889,-0.515402187053192,"ARFGEF1","ADP ribosylation factor guanine nucleotide exchange factor 1",TRUE
+"202956_at",0.870517518639056,0.509553129170008,-0.67036431714218,-5.72314178043435,-0.417487908911543,"ARFGEF1","ADP ribosylation factor guanine nucleotide exchange factor 1",TRUE
+"216266_s_at",0.875187315707138,0.522151946992238,-0.650352036400391,-5.73574973566676,-0.315669858289191,"ARFGEF1","ADP ribosylation factor guanine nucleotide exchange factor 1",TRUE
+"215931_s_at",0.545412722791443,0.0470427105906338,-2.10301758138909,-3.98843518768481,-0.962312484863975,"ARFGEF2","ADP ribosylation factor guanine nucleotide exchange factor 2",TRUE
+"218098_at",0.597879550155311,0.0753039958462271,-1.86621501765772,-4.37232377378769,-0.669617236285413,"ARFGEF2","ADP ribosylation factor guanine nucleotide exchange factor 2",TRUE
+"222518_at",0.663566587754224,0.131530357113207,-1.56595696592832,-4.81105068901963,-0.637770101929851,"ARFGEF2","ADP ribosylation factor guanine nucleotide exchange factor 2",TRUE
+"215927_at",0.947969282616012,0.763624920888043,0.304451712934214,-5.89463775397148,0.228002006444544,"ARFGEF2","ADP ribosylation factor guanine nucleotide exchange factor 2",TRUE
+"231856_at",0.819018525257656,0.373696160183059,-0.907908453250301,-5.54598074155543,-0.766830969868447,"ARFGEF3","ARFGEF family member 3",TRUE
+"228051_at",0.930899509890345,0.69422402788783,-0.398296055543156,-5.86270990539739,-0.28699973586852,"ARFGEF3","ARFGEF family member 3",TRUE
+"242098_at",0.933922051839063,0.707296832839092,-0.380364603152002,-5.8694611607801,-0.290845892477826,"ARFGEF3","ARFGEF family member 3",TRUE
+"236037_at",0.96287357728432,0.8313099679802,0.215550582375681,-5.91707883107214,0.277777155166377,"ARFGEF3","ARFGEF family member 3",TRUE
+"218230_at",0.314126572995991,0.00668485918144907,-2.99195404272841,-2.32420833666558,-1.03563994175351,"ARFIP1","ADP ribosylation factor interacting protein 1",TRUE
+"214483_s_at",0.48580305784244,0.0285697136699082,-2.34197854810737,-3.57188698678132,-0.71203610693683,"ARFIP1","ADP ribosylation factor interacting protein 1",TRUE
+"202109_at",0.6708432030569,0.136806615712564,-1.54377386131163,-4.84112147576177,-0.734417653249936,"ARFIP2","ADP ribosylation factor interacting protein 2",TRUE
+"203174_s_at",0.438840784067841,0.0201702220459531,-2.50307239578453,-3.27670261612369,-0.79626872688813,"ARFRP1","ADP ribosylation factor related protein 1",TRUE
+"215984_s_at",0.593075760249563,0.0698565687427011,-1.9048880631841,-4.31177336944126,-0.552037751977474,"ARFRP1","ADP ribosylation factor related protein 1",TRUE
+"231665_at",0.710842845257879,0.184447636458818,-1.3698805125187,-5.06480531398645,-1.26511334966137,"ARG1","arginase 1",TRUE
+"231663_s_at",0.90578639555441,0.612140965994247,0.514290111186759,-5.81167270381256,0.342170556610512,"ARG1","arginase 1",TRUE
+"206177_s_at",0.910159094731364,0.625856831591911,-0.494447863192947,-5.82130336319175,-0.346642354306654,"ARG1","arginase 1",TRUE
+"231662_at",0.99176128617116,0.961988416658527,-0.0482003498628666,-5.9385519631271,-0.0304332323816863,"ARG1","arginase 1",TRUE
+"203945_at",0.685154158710982,0.153740619200031,1.47703174706498,-4.92953146295109,0.448245200701177,"ARG2","arginase 2",TRUE
+"203946_s_at",0.9340157600858,0.707716596412154,0.379790960392738,-5.86967207923174,0.287729138395331,"ARG2","arginase 2",TRUE
+"218067_s_at",0.524535814616423,0.0390847537036544,2.19308679062604,-3.834636977007,0.701586522084918,"ARGLU1","arginine and glutamate rich 1",TRUE
+"228477_at",0.535243600695458,0.042801055373402,2.14914451977139,-3.91017622393876,1.20589085241897,"ARGLU1","arginine and glutamate rich 1",TRUE
+"227448_at",0.808257777979515,0.350807455195909,0.953130020503744,-5.50663693960715,0.426118006448958,"ARGLU1","arginine and glutamate rich 1",TRUE
+"222508_s_at",0.841967750949524,0.434941670562099,0.795185701050099,-5.63630897310763,0.648607757753327,"ARGLU1","arginine and glutamate rich 1",TRUE
+"217153_at",0.667641453131852,0.134045876014989,-1.55529093064739,-4.8255514851262,-1.04360762744892,"ARHGAP1","Rho GTPase activating protein 1",TRUE
+"202117_at",0.697912155587754,0.168851979773476,-1.42234650507632,-4.99961287354023,-0.435839419877158,"ARHGAP1","Rho GTPase activating protein 1",TRUE
+"216689_x_at",0.913782990161554,0.6383997249418,-0.476477209471196,-5.82970617109516,-0.150969579322458,"ARHGAP1","Rho GTPase activating protein 1",TRUE
+"241419_at",0.971216837324271,0.863010391691728,0.174560280276954,-5.92485292685459,0.0923375265134672,"ARHGAP1","Rho GTPase activating protein 1",TRUE
+"219431_at",0.902770867950228,0.602295813328077,0.528662321705104,-5.80446640097357,0.399858750363324,"ARHGAP10","Rho GTPase activating protein 10",TRUE
+"204492_at",0.7768734672127,0.294582352465577,1.07353953243229,-5.39341760127427,0.486895493150007,"ARHGAP11A","Rho GTPase activating protein 11A",TRUE
+"207606_s_at",0.870821088754219,0.510515379201445,0.668826217753701,-5.72412378805528,0.281898494210351,"ARHGAP12","Rho GTPase activating protein 12",TRUE
+"218076_s_at",0.968035667633768,0.849231989790198,-0.19233467288589,-5.92168178132668,-0.0612390314935016,"ARHGAP17","Rho GTPase activating protein 17",TRUE
+"225166_at",0.704427751516111,0.176316301408285,1.39677444785264,-5.03164073492862,1.32969802511335,"ARHGAP18","Rho GTPase activating protein 18",TRUE
+"225173_at",0.733012446828677,0.217454283166118,1.26944645027859,-5.18385876668231,0.901972882101401,"ARHGAP18","Rho GTPase activating protein 18",TRUE
+"225171_at",0.835289077598304,0.414464219480217,0.831678517871669,-5.60828835656682,0.681062946741548,"ARHGAP18","Rho GTPase activating protein 18",TRUE
+"1557615_a_at",0.90344422113846,0.604384734068812,0.525603527928758,-5.80601629870991,0.342154008081219,"ARHGAP19","Rho GTPase activating protein 19",TRUE
+"37577_at",0.942303845415102,0.740397283786335,0.335508938978043,-5.88500484172837,0.121671989056452,"ARHGAP19","Rho GTPase activating protein 19",TRUE
+"212738_at",0.949108933724268,0.77039034829484,0.2954643279644,-5.89725249592829,0.128684744033263,"ARHGAP19","Rho GTPase activating protein 19",TRUE
+"1555020_a_at",0.844169896707408,0.440567576070253,0.785347302421578,-5.64366105000051,0.50079461147542,"ARHGAP20","Rho GTPase activating protein 20",TRUE
+"228368_at",0.934612165247339,0.709826614758039,-0.376909400293239,-5.87072682896086,-0.305539063235615,"ARHGAP20","Rho GTPase activating protein 20",TRUE
+"241701_at",0.62986301194198,0.101083918096601,1.71080528976332,-4.6065778061999,0.784211216208295,"ARHGAP21","Rho GTPase activating protein 21",TRUE
+"224764_at",0.760227035076299,0.258066858645351,1.16082699394943,-5.30384034111383,0.638026096527529,"ARHGAP21","Rho GTPase activating protein 21",TRUE
+"206298_at",0.833226189657242,0.410587138811694,0.838714598438497,-5.60275046180964,0.977607443763004,"ARHGAP22","Rho GTPase activating protein 22",TRUE
+"1560765_a_at",0.857287594027564,0.472286784924715,0.731255002987767,-5.68253742195354,0.564203906052099,"ARHGAP22","Rho GTPase activating protein 22",TRUE
+"1560764_at",0.94895689004559,0.769208574904886,-0.297032418197183,-5.89680187789808,-0.208762877635723,"ARHGAP22","Rho GTPase activating protein 22",TRUE
+"1560821_at",0.973071267819624,0.870177700115367,0.165337396606281,-5.92637766589711,0.0811208843508986,"ARHGAP22","Rho GTPase activating protein 22",TRUE
+"1556460_a_at",0.868397087637799,0.503784038078389,0.679620215964417,-5.71718672213933,0.397239382259452,"ARHGAP22-IT1","ARHGAP22 intronic transcript 1",TRUE
+"1556459_at",0.969891556938326,0.857406281738637,0.181782412128555,-5.92360135959235,0.106813414927334,"ARHGAP22-IT1","ARHGAP22 intronic transcript 1",TRUE
+"226638_at",0.246251630977243,0.00337343340835766,3.28307070145239,-1.72646535597875,3.5820833141019,"ARHGAP23","Rho GTPase activating protein 23",TRUE
+"231903_x_at",0.577403980266925,0.0615158332886115,1.96957106434773,-4.20858099562877,0.728160055775501,"ARHGAP23","Rho GTPase activating protein 23",TRUE
+"230013_s_at",0.606236396254745,0.0799112155063182,1.83536782793608,-4.41999053990907,1.4052054313384,"ARHGAP23","Rho GTPase activating protein 23",TRUE
+"230196_x_at",0.76772687203753,0.269601140146,1.13233108899717,-5.33376423299277,0.396224836168971,"ARHGAP23","Rho GTPase activating protein 23",TRUE
+"230802_at",0.636147339487472,0.107440669094095,1.6777862057675,-4.65440223923481,1.36379855617701,"ARHGAP24","Rho GTPase activating protein 24",TRUE
+"221030_s_at",0.76912869907427,0.274654745827637,1.12012771724239,-5.34637842218615,0.761106943383537,"ARHGAP24","Rho GTPase activating protein 24",TRUE
+"223422_s_at",0.879161148925378,0.53294513430233,0.633418076763793,-5.74613169998253,0.600790436744168,"ARHGAP24","Rho GTPase activating protein 24",TRUE
+"230803_s_at",0.8796702619256,0.534270884562031,0.631350937965828,-5.74738099540839,0.553334423828426,"ARHGAP24","Rho GTPase activating protein 24",TRUE
+"38149_at",0.895213601869362,0.573413665220994,-0.571499197379784,-5.78184307107354,-0.235128332996031,"ARHGAP25","Rho GTPase activating protein 25",TRUE
+"1555076_at",0.941106542715586,0.735998198949154,0.341428013036751,-5.88306397898946,0.0977184628818604,"ARHGAP25","Rho GTPase activating protein 25",TRUE
+"204882_at",0.969829083058377,0.855541765378403,-0.184187428722086,-5.92317335522476,-0.111043716447645,"ARHGAP25","Rho GTPase activating protein 25",TRUE
+"215955_x_at",0.656641058207682,0.124614830637528,1.596176983486,-4.7695443279153,1.50442593934319,"ARHGAP26","Rho GTPase activating protein 26",TRUE
+"205069_s_at",0.717994416213789,0.193960265706039,1.33958295991036,-5.10152287003308,0.876798159486964,"ARHGAP26","Rho GTPase activating protein 26",TRUE
+"205068_s_at",0.793016712530949,0.324879051387136,1.00684502276679,-5.45763503674677,0.53835586954652,"ARHGAP26","Rho GTPase activating protein 26",TRUE
+"226576_at",0.839705010166836,0.428383938702946,0.80675330969388,-5.62755461609674,0.69867597332235,"ARHGAP26","Rho GTPase activating protein 26",TRUE
+"1560856_at",0.760227035076299,0.258140605689228,1.16064183925118,-5.30403688327257,0.718598159255983,"ARHGAP26-AS1","ARHGAP26 antisense RNA 1",TRUE
+"225618_at",0.620223198657182,0.0902173772093382,1.77159099878273,-4.51672422023406,0.718734842017671,"ARHGAP27","Rho GTPase activating protein 27",TRUE
+"1554594_at",0.647754107214051,0.119161044840021,1.62101111764096,-4.73497375301291,1.75093406385067,"ARHGAP27","Rho GTPase activating protein 27",TRUE
+"227057_at",0.832758870942732,0.409587545291336,0.840535476286722,-5.60131020199735,1.02518130908596,"ARHGAP27","Rho GTPase activating protein 27",TRUE
+"229424_s_at",0.85069818933195,0.453783496879128,0.762533787239509,-5.66037699059948,0.421035968642697,"ARHGAP27","Rho GTPase activating protein 27",TRUE
+"243536_x_at",0.87825255145971,0.530357335877605,0.637461059229803,-5.74367693102736,0.228025284053848,"ARHGAP27","Rho GTPase activating protein 27",TRUE
+"220381_at",0.758920166935337,0.25628840857156,1.16530402812533,-5.29907959134568,1.08356009712726,"ARHGAP28","Rho GTPase activating protein 28",TRUE
+"227911_at",0.904832003218088,0.61021528304463,0.517092561937764,-5.81028272735129,0.591178894351668,"ARHGAP28","Rho GTPase activating protein 28",TRUE
+"220382_s_at",0.931370027472813,0.695602374286976,-0.396399255481553,-5.86343854625182,-0.360777197628916,"ARHGAP28","Rho GTPase activating protein 28",TRUE
+"1560318_at",0.508488499910913,0.0335263894211509,2.26647114310764,-3.70641283293683,1.90373968864663,"ARHGAP29","Rho GTPase activating protein 29",TRUE
+"203910_at",0.57079525549069,0.0590683046285565,1.99002278123784,-4.17546520179437,1.41381347631894,"ARHGAP29","Rho GTPase activating protein 29",TRUE
+"1558280_s_at",0.641112145892678,0.111630317858222,1.65691741044397,-4.68426410633997,1.45877586054987,"ARHGAP29","Rho GTPase activating protein 29",TRUE
+"1554736_at",0.954387719376857,0.790053947622018,-0.269480157289291,-5.9043749389249,-0.189638998149468,"ARHGAP29","Rho GTPase activating protein 29",TRUE
+"226219_at",0.948989397056643,0.770001844350878,0.295979748603483,-5.89710464176892,0.147378774308821,"ARHGAP30","Rho GTPase activating protein 30",TRUE
+"243433_at",0.956239592379877,0.801772137786387,-0.2540861392413,-5.9082876272951,-0.0944988832284306,"ARHGAP30","Rho GTPase activating protein 30",TRUE
+"241346_at",0.986145735582101,0.93229458153129,0.0859290822692504,-5.93608774032918,0.0634875108155457,"ARHGAP30","Rho GTPase activating protein 30",TRUE
+"226056_at",0.559434208511607,0.0540296383915254,2.03461065089301,-4.10247498132859,2.32046449644868,"ARHGAP31","Rho GTPase activating protein 31",TRUE
+"226057_at",0.990810941805126,0.95679031148882,-0.0547982579767724,-5.93822100951006,-0.0489822849414185,"ARHGAP31","Rho GTPase activating protein 31",TRUE
+"210791_s_at",0.579421528240389,0.062377231188348,1.96254426975329,-4.21990538441883,0.723935149236233,"ARHGAP32","Rho GTPase activating protein 32",TRUE
+"203431_s_at",0.819479221404744,0.376490807305123,0.902514686704152,-5.55055579562577,0.329516165880774,"ARHGAP32","Rho GTPase activating protein 32",TRUE
+"229648_at",0.841391443291102,0.431893073125418,0.80054978445165,-5.63226421364533,0.355238663917596,"ARHGAP32","Rho GTPase activating protein 32",TRUE
+"242196_at",0.897401619272848,0.58400945997629,0.555662407282522,-5.79040621123421,0.19862126069065,"ARHGAP32","Rho GTPase activating protein 32",TRUE
+"213827_at",0.517654151778308,0.0366712312487097,-2.2237017689948,-3.78145357266669,-0.864575169563201,"ARHGAP33","Rho GTPase activating protein 33",TRUE
+"215256_x_at",0.665693790498154,0.132895248711246,-1.56014896332522,-4.81895651751052,-0.885849850723396,"ARHGAP33","Rho GTPase activating protein 33",TRUE
+"233885_at",0.803566977998733,0.341772378006222,-0.971528758165587,-5.4901283099752,-0.395431340723865,"ARHGAP33","Rho GTPase activating protein 33",TRUE
+"229394_s_at",0.611709392215509,0.0835974865776732,-1.81178020541629,-4.45605542292201,-0.649846548957175,"ARHGAP35","Rho GTPase activating protein 35",TRUE
+"202045_s_at",0.7580556532611,0.25465789142671,-1.16942896694856,-5.29467903985447,-0.391080401400977,"ARHGAP35","Rho GTPase activating protein 35",TRUE
+"202046_s_at",0.80110325033185,0.337812414729061,-0.979697443086075,-5.48270646199415,-0.381885568463462,"ARHGAP35","Rho GTPase activating protein 35",TRUE
+"202044_at",0.835838027302116,0.415405170324084,-0.829977178100587,-5.60962088206347,-0.522385592083039,"ARHGAP35","Rho GTPase activating protein 35",TRUE
+"229397_s_at",0.873370488504028,0.518607156465876,-0.655955379570419,-5.73225650304984,-0.301893227800409,"ARHGAP35","Rho GTPase activating protein 35",TRUE
+"238047_at",0.775351898377291,0.292253093863848,-1.07886539404558,-5.38813034009983,-1.97749628020476,"ARHGAP36","Rho GTPase activating protein 36",TRUE
+"227876_at",0.941400961503247,0.73806442233445,-0.338646324064047,-5.88398027490828,-0.138649260036841,"ARHGAP39","Rho GTPase activating protein 39",TRUE
+"204425_at",0.724853010944214,0.202360314196046,1.31378377429673,-5.13224493637604,1.24161226393955,"ARHGAP4","Rho GTPase activating protein 4",TRUE
+"230047_at",0.309168889494955,0.00649721177923554,3.00421623978976,-2.29941507126487,3.64064397156076,"ARHGAP42","Rho GTPase activating protein 42",TRUE
+"1553383_at",0.76912869907427,0.274770114983649,1.119851048875,-5.34666300277067,0.759875323993621,"ARHGAP42","Rho GTPase activating protein 42",TRUE
+"233923_at",0.855405088766616,0.468306745494244,0.737920676854962,-5.67788868981462,0.47681007421886,"ARHGAP42","Rho GTPase activating protein 42",TRUE
+"205414_s_at",0.761748280722165,0.260931371148843,-1.15366374720206,-5.3114240812009,-1.41476712965234,"ARHGAP44","Rho GTPase activating protein 44",TRUE
+"215232_at",0.950340142951297,0.774403372453756,0.290145076916871,-5.89876345342643,0.0927449414154644,"ARHGAP44","Rho GTPase activating protein 44",TRUE
+"212873_at",0.834504305810205,0.413022055869361,0.834290850159397,-5.60623735559578,0.931443265892383,"ARHGAP45","Rho GTPase activating protein 45",TRUE
+"217614_at",0.955552865298326,0.796378790494674,-0.261163280858043,-5.90651722061834,-0.0934547648630542,"ARHGAP45","Rho GTPase activating protein 45",TRUE
+"233849_s_at",0.822372058422737,0.387187956614871,-0.882108735947739,-5.56763607083938,-0.448514646738449,"ARHGAP5","Rho GTPase activating protein 5",TRUE
+"217936_at",0.948109877411639,0.764196657014301,-0.303691222148217,-5.8948620147085,-0.115981085359662,"ARHGAP5","Rho GTPase activating protein 5",TRUE
+"235635_at",0.95743098854986,0.807939539415568,0.246009483740183,-5.91024901059865,0.112892722100391,"ARHGAP5","Rho GTPase activating protein 5",TRUE
+"1552627_a_at",0.983777183253528,0.920540414710736,-0.100896072972383,-5.93472638560423,-0.044772355131661,"ARHGAP5","Rho GTPase activating protein 5",TRUE
+"233872_x_at",0.996261754016157,0.981839234385665,0.0230214543038068,-5.93942534674421,0.013893614219346,"ARHGAP5","Rho GTPase activating protein 5",TRUE
+"228889_at",0.774230543658252,0.288867357134705,-1.08666152772832,-5.38034859406858,-0.495987004600134,"ARHGAP5-AS1","ARHGAP5 antisense RNA 1 (head to head)",TRUE
+"206167_s_at",0.512957854428756,0.0343785665417348,-2.25453170829779,-3.72744705513901,-1.98316022873542,"ARHGAP6","Rho GTPase activating protein 6",TRUE
+"208085_s_at",0.710383535193614,0.183336302882726,1.37350000079762,-5.06037307954835,0.841525604830485,"ARHGAP6","Rho GTPase activating protein 6",TRUE
+"224451_x_at",0.539114280228505,0.0441836716570531,2.13367303651263,-3.93654488783363,0.813793156642647,"ARHGAP9","Rho GTPase activating protein 9",TRUE
+"226906_s_at",0.769424525862551,0.276837438056719,1.11490767375865,-5.3517372549007,0.810581145323797,"ARHGAP9","Rho GTPase activating protein 9",TRUE
+"232543_x_at",0.8920930097751,0.563375469799435,0.586639940030712,-5.77343836901136,0.328928528720429,"ARHGAP9","Rho GTPase activating protein 9",TRUE
+"201168_x_at",0.820536502908875,0.380379038481656,-0.895053994519186,-5.55684250088522,-0.354878612874099,"ARHGDIA","Rho GDP dissociation inhibitor alpha",TRUE
+"211716_x_at",0.913123070637484,0.635028481746099,-0.481291445467773,-5.82748492916787,-0.1687596373055,"ARHGDIA","Rho GDP dissociation inhibitor alpha",TRUE
+"213606_s_at",0.942684843065067,0.743364280389685,-0.331523677977423,-5.88629269413254,-0.224388529098237,"ARHGDIA","Rho GDP dissociation inhibitor alpha",TRUE
+"201167_x_at",0.98672253748883,0.938139875012014,0.0784937649029807,-5.93668299825148,0.0488399556551311,"ARHGDIA","Rho GDP dissociation inhibitor alpha",TRUE
+"1555812_a_at",0.55074985379986,0.0490876303347278,2.0821026451597,-4.02356161051116,2.94825532582676,"ARHGDIB","Rho GDP dissociation inhibitor beta",TRUE
+"201288_at",0.579147493561207,0.0623371376242836,1.9628694212537,-4.21938197717579,3.17176402892456,"ARHGDIB","Rho GDP dissociation inhibitor beta",TRUE
+"1555811_at",0.758081075834994,0.254868057835762,1.16889618104655,-5.2952481902293,0.697336316879314,"ARHGDIB","Rho GDP dissociation inhibitor beta",TRUE
+"206888_s_at",0.9330573785522,0.704415406034145,-0.384305841081305,-5.86800354972601,-0.183350179519098,"ARHGDIG","Rho GDP dissociation inhibitor gamma",TRUE
+"1560445_x_at",0.980009054680439,0.905660040654948,-0.119878150569812,-5.93268643111517,-0.0317734576842135,"ARHGEF1","Rho guanine nucleotide exchange factor 1",TRUE
+"1554213_at",0.731054546207485,0.214024024200933,1.27930865505166,-5.17250840960129,0.421505045518075,"ARHGEF10","Rho guanine nucleotide exchange factor 10",TRUE
+"216620_s_at",0.782096995485383,0.303835493146675,1.05267474287944,-5.41390540371613,0.752394233826232,"ARHGEF10","Rho guanine nucleotide exchange factor 10",TRUE
+"1554703_at",0.789378278298554,0.315868932216333,1.0262045306191,-5.43937692345322,1.18574751604806,"ARHGEF10","Rho guanine nucleotide exchange factor 10",TRUE
+"215139_at",0.982834147892409,0.916314156464421,0.106283108319824,-5.93418306463187,0.094161297592688,"ARHGEF10","Rho guanine nucleotide exchange factor 10",TRUE
+"221656_s_at",0.822600785740588,0.38764921787069,-0.881237173550941,-5.56835753001607,-0.391017398778169,"ARHGEF10L","Rho guanine nucleotide exchange factor 10 like",TRUE
+"1570511_at",0.834454640870101,0.41280478808039,0.834684908705208,-5.60592744938441,0.51478875556116,"ARHGEF10L","Rho guanine nucleotide exchange factor 10 like",TRUE
+"238730_at",0.809707978333974,0.353015746336202,0.948682179553615,-5.51058449349385,0.484160204264721,"ARHGEF11","Rho guanine nucleotide exchange factor 11",TRUE
+"202913_at",0.814143616628706,0.365117539638516,-0.924634370280286,-5.53163379492657,-0.290130902870748,"ARHGEF11","Rho guanine nucleotide exchange factor 11",TRUE
+"202914_s_at",0.87048825824408,0.509253542353821,-0.670843520481645,-5.72283538926159,-0.238859155366233,"ARHGEF11","Rho guanine nucleotide exchange factor 11",TRUE
+"1570471_at",0.614411830126793,0.085296293191416,1.80121180404379,-4.47210503497821,1.20570925471383,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"210741_at",0.642592458809121,0.112784367006157,-1.65128526507422,-4.69227452447027,-1.12587632768718,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"201334_s_at",0.677509122383198,0.14503399106809,-1.51055060255528,-4.88552106323943,-0.555519851557666,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"234544_at",0.707593266152278,0.178996566095188,-1.38780274906991,-5.04276369546138,-0.876517938853052,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"233620_at",0.718876316641862,0.194895356956238,1.3366682548897,-5.10501892142359,1.32757333008206,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"234129_at",0.722937902375896,0.199483401030048,-1.32252383658823,-5.12189351327106,-0.839569926208978,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"234541_s_at",0.812667892490208,0.36137895692939,0.932005540805826,-5.52523450774719,0.527510188330632,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"1566093_at",0.853093296743962,0.459461052035302,0.752856530800061,-5.6673270430662,0.393902627771533,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"1559833_at",0.884766357907703,0.544452933000543,0.615565882798465,-5.75679116477847,0.60653818423712,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"234542_at",0.893334037681196,0.567882794318004,-0.579824564672241,-5.77724794632,-0.22783972316529,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"201333_s_at",0.943464796017993,0.747080925081571,0.326539197765822,-5.88788201426723,0.105616425388241,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"201335_s_at",0.992820830895496,0.966065275522433,0.0430271785441136,-5.93878180245074,0.0290701971287586,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"233621_s_at",0.997466539876354,0.987177173100126,-0.0162540756164831,-5.93955480193721,-0.0110851385154529,"ARHGEF12","Rho guanine nucleotide exchange factor 12",TRUE
+"205507_at",0.968271298107834,0.851087005843005,0.189938100415884,-5.92212721702343,0.0699342321278689,"ARHGEF15","Rho guanine nucleotide exchange factor 15",TRUE
+"217348_x_at",0.98693003519805,0.939821764712478,0.0763552298489425,-5.93684424261043,0.0375011757176988,"ARHGEF15","Rho guanine nucleotide exchange factor 15",TRUE
+"208009_s_at",0.922874120900065,0.669752578750685,0.43222884969713,-5.84909686656287,0.298340192239959,"ARHGEF16","Rho guanine nucleotide exchange factor 16",TRUE
+"203756_at",0.991059530537351,0.95841392990639,-0.0527371601038035,-5.93832894763387,-0.020321745154158,"ARHGEF17","Rho guanine nucleotide exchange factor 17",TRUE
+"213039_at",0.585153599357259,0.0657127224518256,1.93611929978723,-4.26224429774786,0.727506058244177,"ARHGEF18","Rho/Rac guanine nucleotide exchange factor 18",TRUE
+"226857_at",0.875279162021058,0.522508602037807,0.649789423059075,-5.73609889069301,0.472294632172206,"ARHGEF19","Rho guanine nucleotide exchange factor 19",TRUE
+"209435_s_at",0.756388854702832,0.251686921510903,1.17699580699997,-5.28657124683589,0.556646163734202,"ARHGEF2","Rho/Rac guanine nucleotide exchange factor 2",TRUE
+"235595_at",0.87420326280133,0.520076991845247,0.653629419266814,-5.73371004269331,0.305166461779218,"ARHGEF2","Rho/Rac guanine nucleotide exchange factor 2",TRUE
+"207629_s_at",0.899808883319249,0.593516818653016,0.54157379591932,-5.79782771863526,0.249422286460252,"ARHGEF2","Rho/Rac guanine nucleotide exchange factor 2",TRUE
+"1554783_s_at",0.922562383585776,0.668969515494132,0.433323014894708,-5.84863971925208,0.400566109668999,"ARHGEF2","Rho/Rac guanine nucleotide exchange factor 2",TRUE
+"227427_at",0.932091525948902,0.700515230242998,0.38965043475724,-5.8660032667166,0.25269270480545,"ARHGEF25","Rho guanine nucleotide exchange factor 25",TRUE
+"233903_s_at",0.603702127972549,0.0781278323099219,-1.84712003753257,-4.40189707281067,-1.08152276376466,"ARHGEF26","Rho guanine nucleotide exchange factor 26",TRUE
+"227197_at",0.678791533182461,0.146385568683208,-1.50524143379425,-4.8925448202978,-1.20607818633165,"ARHGEF26","Rho guanine nucleotide exchange factor 26",TRUE
+"222121_at",0.76469251347209,0.264789570532265,-1.14410687324723,-5.32147770196121,-1.05269355537833,"ARHGEF26","Rho guanine nucleotide exchange factor 26",TRUE
+"236575_at",0.687545925823023,0.156541539904345,-1.46657730336401,-4.94309523478061,-1.73480836482371,"ARHGEF26-AS1","ARHGEF26 antisense RNA 1",TRUE
+"1559706_at",0.545204992413686,0.0469569329542944,2.10391261546267,-3.98692695811507,1.30066956074145,"ARHGEF28","Rho guanine nucleotide exchange factor 28",TRUE
+"219610_at",0.662855903464759,0.130710912520034,1.56946795731998,-4.8062603482049,1.02690492260349,"ARHGEF28","Rho guanine nucleotide exchange factor 28",TRUE
+"232994_s_at",0.699684100574767,0.171169126980114,1.41431305561154,-5.00972591318551,1.34743163609817,"ARHGEF28","Rho guanine nucleotide exchange factor 28",TRUE
+"1554003_at",0.700430227058786,0.172141324966675,1.410968394107,-5.01392251114779,0.474158355794055,"ARHGEF28","Rho guanine nucleotide exchange factor 28",TRUE
+"1554004_a_at",0.726480797733202,0.205505391839084,1.30433904653554,-5.14336570706828,1.17613961230247,"ARHGEF28","Rho guanine nucleotide exchange factor 28",TRUE
+"1560348_at",0.848905954771492,0.449373445299258,0.770101076460208,-5.65488383269277,0.327609601637246,"ARHGEF28","Rho guanine nucleotide exchange factor 28",TRUE
+"218501_at",0.831487912516861,0.406104940429617,0.846901630108746,-5.59625184871443,0.409531465289946,"ARHGEF3","Rho guanine nucleotide exchange factor 3",TRUE
+"1556881_at",0.711427723123186,0.185081809487045,1.36782280763016,-5.0673207303375,0.661007853458832,"ARHGEF33","Rho guanine nucleotide exchange factor 33",TRUE
+"233492_s_at",0.813641569007658,0.364501085805017,-0.925846315078574,-5.53058485551805,-0.677809371608532,"ARHGEF34P///OR2A7///OR2A4","Rho guanine nucleotide exchange factor 34, pseudogene///olfactory receptor family 2 subfamily A member 7///olfactory receptor family 2 subfamily A member 4",TRUE
+"241380_at",0.780674131139921,0.302377130524985,1.05593285024252,-5.41072991925641,0.414364375381571,"ARHGEF37","Rho guanine nucleotide exchange factor 37",TRUE
+"227717_at",0.894669569649753,0.571426722299754,0.574485328304668,-5.78020230131285,0.681707724472584,"ARHGEF37","Rho guanine nucleotide exchange factor 37",TRUE
+"221119_at",0.683019114815084,0.152047670102314,1.48342591607853,-4.92119722372057,0.917506570121262,"ARHGEF38","Rho guanine nucleotide exchange factor 38",TRUE
+"230521_at",0.91876780831279,0.65485594673314,0.453137792109194,-5.84016477705373,0.226554066676287,"ARHGEF39","Rho guanine nucleotide exchange factor 39",TRUE
+"231892_at",0.928576500287959,0.68600722103155,-0.409634748440048,-5.85828282328807,-0.130430427271679,"ARHGEF39","Rho guanine nucleotide exchange factor 39",TRUE
+"230522_s_at",0.952293443370532,0.781615315248325,0.280606996942793,-5.90140459353196,0.116223578842913,"ARHGEF39","Rho guanine nucleotide exchange factor 39",TRUE
+"216912_at",0.624965128767163,0.0962628419442618,1.73704711533075,-4.56807235306107,1.11414768102338,"ARHGEF4","Rho guanine nucleotide exchange factor 4",TRUE
+"237954_x_at",0.432151440378733,0.0192766947352057,2.52374569045119,-3.23806475711295,1.70506467414314,"ARHGEF40","Rho guanine nucleotide exchange factor 40",TRUE
+"227855_at",0.459154397418224,0.0229744530825907,2.44331785351145,-3.38743932198619,1.5542379239087,"ARHGEF40","Rho guanine nucleotide exchange factor 40",TRUE
+"220326_s_at",0.565043084457947,0.0563277242705085,2.01383511534021,-4.13661853846333,2.26102487168358,"ARHGEF40","Rho guanine nucleotide exchange factor 40",TRUE
+"58780_s_at",0.597654932724127,0.074990266516573,1.8683748263328,-4.36896521425469,2.02273751364497,"ARHGEF40","Rho guanine nucleotide exchange factor 40",TRUE
+"241631_at",0.620437879410052,0.0903025053609948,1.77109096394278,-4.51747280533644,1.07742746432151,"ARHGEF40","Rho guanine nucleotide exchange factor 40",TRUE
+"241627_x_at",0.755005474102847,0.248546482813587,1.18506701015021,-5.27787269081282,0.414383433338815,"ARHGEF40","Rho guanine nucleotide exchange factor 40",TRUE
+"204765_at",0.906507435035949,0.614261274330649,-0.5112092384879,-5.81319227617228,-0.210456560023133,"ARHGEF5","Rho guanine nucleotide exchange factor 5",TRUE
+"228596_at",0.957571530817866,0.809548404499526,0.243905329321767,-5.91074965454107,0.126465061003872,"ARHGEF5","Rho guanine nucleotide exchange factor 5",TRUE
+"209539_at",0.982918077318203,0.917298119313292,0.105028610078549,-5.9343121108458,0.109496228333455,"ARHGEF6","Rac/Cdc42 guanine nucleotide exchange factor 6",TRUE
+"202547_s_at",0.267497559720232,0.00409502437102578,3.20122633250399,-1.89629997485696,1.01136687218622,"ARHGEF7","Rho guanine nucleotide exchange factor 7",TRUE
+"229642_at",0.517654151778308,0.0367748639773742,2.22235007989278,-3.7838111423459,0.959329319281917,"ARHGEF7","Rho guanine nucleotide exchange factor 7",TRUE
+"202548_s_at",0.603702127972549,0.077645954855939,1.85033554080726,-4.39693220431849,0.630455851599775,"ARHGEF7","Rho guanine nucleotide exchange factor 7",TRUE
+"242999_at",0.70573152022539,0.178026469902925,1.3910375502805,-5.03876008014952,0.889193018317189,"ARHGEF7","Rho guanine nucleotide exchange factor 7",TRUE
+"1562270_at",0.710824498521146,0.18409118199047,1.37103956013908,-5.0633870645491,1.17560355954265,"ARHGEF7","Rho guanine nucleotide exchange factor 7",TRUE
+"236416_at",0.729592921898444,0.211865511129064,1.28557711767586,-5.16525515424714,0.799415092913968,"ARHGEF7","Rho guanine nucleotide exchange factor 7",TRUE
+"235412_at",0.797896456623304,0.331877109190904,0.992065022250827,-5.47136194319415,0.802871680634492,"ARHGEF7","Rho guanine nucleotide exchange factor 7",TRUE
+"1562271_x_at",0.813199854092954,0.363058224753708,0.92868833566588,-5.52812012579957,0.317163703127965,"ARHGEF7","Rho guanine nucleotide exchange factor 7",TRUE
+"239397_at",0.983364220761052,0.919032339353158,-0.102817994367899,-5.93453578478939,-0.0754585789462245,"ARHGEF7","Rho guanine nucleotide exchange factor 7",TRUE
+"1557439_at",0.754682106570676,0.248291129209867,1.1857266329353,-5.27715950451573,0.973657749977477,"ARHGEF7-AS2","ARHGEF7 antisense RNA 2",TRUE
+"1560510_at",0.941400961503247,0.737867719418675,0.338911021108967,-5.88389340211576,0.306917099881865,"ARHGEF7-IT1","ARHGEF7 intronic transcript 1",TRUE
+"203264_s_at",0.254241144183229,0.00361773406812166,-3.25360421793974,-1.78775556603401,-2.50405961547926,"ARHGEF9","Cdc42 guanine nucleotide exchange factor 9",TRUE
+"203263_s_at",0.465776708318531,0.0240840131154941,-2.42152998790543,-3.42745867242675,-1.60344866315011,"ARHGEF9","Cdc42 guanine nucleotide exchange factor 9",TRUE
+"207591_s_at",0.857148066512338,0.471959140434735,0.731802479472753,-5.68215711383126,0.490841204614251,"ARID1A","AT-rich interaction domain 1A",TRUE
+"210649_s_at",0.895999830738594,0.576967562040987,0.566171164789236,-5.78475004588252,0.228908807265592,"ARID1A","AT-rich interaction domain 1A",TRUE
+"212152_x_at",0.995432017261604,0.978692895028946,0.0270108434125733,-5.93932813272055,0.00928395717810382,"ARID1A","AT-rich interaction domain 1A",TRUE
+"218917_s_at",0.998347572104896,0.993066799661231,-0.00878816298167185,-5.93964586405265,-0.00328432397861711,"ARID1A","AT-rich interaction domain 1A",TRUE
+"1566990_x_at",0.761706445087166,0.260840050688011,-1.15389121096151,-5.31118389869499,-0.412980407389625,"ARID1B","AT-rich interaction domain 1B",TRUE
+"1566991_at",0.859662388428617,0.477716000871087,0.722215363977763,-5.68877776846603,0.478377652043984,"ARID1B","AT-rich interaction domain 1B",TRUE
+"233339_s_at",0.885929137203218,0.547963962594694,0.610159328583053,-5.75996145104495,0.182406934483999,"ARID1B","AT-rich interaction domain 1B",TRUE
+"225181_at",0.886783047600321,0.550002342044152,0.607028875300849,-5.76178474753574,0.259541885423838,"ARID1B","AT-rich interaction domain 1B",TRUE
+"1566989_at",0.911934428365482,0.631123673249592,-0.486882095815534,-5.82487805829167,-0.17653295596585,"ARID1B","AT-rich interaction domain 1B",TRUE
+"225184_at",0.955645941042265,0.796956034471513,0.260405177107588,-5.90670917749479,0.0858473861113414,"ARID1B","AT-rich interaction domain 1B",TRUE
+"238043_at",0.977369242833284,0.891556821349299,-0.137910480181479,-5.93042412428064,-0.0606912474340762,"ARID1B","AT-rich interaction domain 1B",TRUE
+"225486_at",0.54295328972902,0.0462275148763225,-2.11158357949965,-3.97398372595422,-0.756614243843885,"ARID2","AT-rich interaction domain 2",TRUE
+"1553349_at",0.627092759817312,0.098247364192042,-1.72611223338958,-4.58417052641369,-1.04571065366452,"ARID2","AT-rich interaction domain 2",TRUE
+"231090_s_at",0.644844656970274,0.115134512101767,-1.63996417874522,-4.70831299453786,-0.655514407652387,"ARID2","AT-rich interaction domain 2",TRUE
+"225490_at",0.689848451630875,0.158742923407969,-1.45846652540964,-4.95356452270338,-0.507399458708216,"ARID2","AT-rich interaction domain 2",TRUE
+"228008_at",0.914335478089317,0.639658564918452,-0.474682479854733,-5.83052865200128,-0.22894897752311,"ARID3A","AT-rich interaction domain 3A",TRUE
+"205865_at",0.961395512423249,0.82504557867961,-0.223693369623496,-5.91534080950557,-0.104276022158229,"ARID3A","AT-rich interaction domain 3A",TRUE
+"218964_at",0.591272702915983,0.0685210884777522,1.91477129608366,-4.29616008940576,1.48614088137414,"ARID3B","AT-rich interaction domain 3B",TRUE
+"205062_x_at",0.381135657631489,0.011983942593987,-2.73712775974156,-2.830187053608,-0.923969117509207,"ARID4A","AT-rich interaction domain 4A",TRUE
+"230141_at",0.54295328972902,0.0460205868736513,-2.11377956776894,-3.97027289511292,-1.09316819827045,"ARID4A","AT-rich interaction domain 4A",TRUE
+"221230_s_at",0.494386911247381,0.0300475117709199,-2.31828399221625,-3.61437682522747,-0.742861105011684,"ARID4B","AT-rich interaction domain 4B",TRUE
+"214139_at",0.690139543208579,0.159766794583739,1.45472514713561,-4.95837796060543,0.424939686211902,"ARID4B","AT-rich interaction domain 4B",TRUE
+"223111_x_at",0.730211867140947,0.212993486184981,-1.28229528966571,-5.16905633290361,-0.387163064659537,"ARID4B","AT-rich interaction domain 4B",TRUE
+"224322_at",0.942961933269639,0.744129451411711,-0.330496792725448,-5.88662206892779,-0.255340445361402,"ARID4B","AT-rich interaction domain 4B",TRUE
+"214943_s_at",0.919354071504066,0.656750695167427,0.450467099650214,-5.84132872402839,0.176443267948267,"ARID4B///RBM34","AT-rich interaction domain 4B///RNA binding motif protein 34",TRUE
+"212591_at",0.942684843065067,0.743304992459335,-0.33160325953857,-5.88626712602879,-0.109768133334608,"ARID4B///RBM34","AT-rich interaction domain 4B///RNA binding motif protein 34",TRUE
+"213138_at",0.534511365932792,0.0424580841399967,2.15305215720072,-3.90349736412805,1.81225352970598,"ARID5A","AT-rich interaction domain 5A",TRUE
+"1558001_s_at",0.65284137151906,0.121984117487939,1.60804025131518,-4.75308157447624,1.2873534722877,"ARID5B","AT-rich interaction domain 5B",TRUE
+"212614_at",0.69734808405399,0.167733418443421,-1.42625617145671,-4.99467412600603,-0.669413380199085,"ARID5B","AT-rich interaction domain 5B",TRUE
+"235404_at",0.843121215318579,0.437463628699407,-0.790765763845661,-5.63962257983572,-0.638015255743078,"ARID5B","AT-rich interaction domain 5B",TRUE
+"1558000_at",0.879579694943027,0.534118435332481,-0.631588499086519,-5.74723762286022,-0.372971037530933,"ARID5B","AT-rich interaction domain 5B",TRUE
+"241969_at",0.943988850936011,0.749630237261989,0.323125135126595,-5.88895684954429,0.268850159724408,"ARID5B","AT-rich interaction domain 5B",TRUE
+"201878_at",0.584828007864693,0.0649736686331745,-1.94187061547252,-4.2530628396054,-0.651292157480018,"ARIH1","ariadne RBR E3 ubiquitin protein ligase 1",TRUE
+"1558401_at",0.683017520100356,0.151278545371106,-1.48635000104217,-4.91737626644992,-0.592166085075209,"ARIH1","ariadne RBR E3 ubiquitin protein ligase 1",TRUE
+"201880_at",0.821600429533552,0.384219533502703,-0.887733903207569,-5.56296378472837,-0.316642048812501,"ARIH1","ariadne RBR E3 ubiquitin protein ligase 1",TRUE
+"201881_s_at",0.868397087637799,0.50378406379099,-0.679620174578716,-5.71718674894069,-0.234473263635037,"ARIH1","ariadne RBR E3 ubiquitin protein ligase 1",TRUE
+"201879_at",0.975265330414469,0.880431416673183,-0.152168196737786,-5.92841174505037,-0.0436565125943975,"ARIH1","ariadne RBR E3 ubiquitin protein ligase 1",TRUE
+"241658_at",0.976371465776674,0.88643851237131,0.144466009630396,-5.92952337433927,0.0619830701784068,"ARIH1","ariadne RBR E3 ubiquitin protein ligase 1",TRUE
+"216008_s_at",0.525405708458677,0.0393742672712632,-2.18953047404756,-3.84078563756806,-0.83364766160272,"ARIH2","ariadne RBR E3 ubiquitin protein ligase 2",TRUE
+"201228_s_at",0.571677937624457,0.0595949124307897,-1.98555985427773,-4.18271134771559,-0.71808836956005,"ARIH2","ariadne RBR E3 ubiquitin protein ligase 2",TRUE
+"227932_at",0.731548533938014,0.215194524054071,-1.27592980812287,-5.17640554702156,-0.478537718490077,"ARIH2","ariadne RBR E3 ubiquitin protein ligase 2",TRUE
+"201229_s_at",0.841967750949524,0.434691137343134,-0.795625642755127,-5.63597820000234,-0.298263026628524,"ARIH2","ariadne RBR E3 ubiquitin protein ligase 2",TRUE
+"201230_s_at",0.983783029912313,0.920794192339196,-0.100572692156359,-5.93475810280609,-0.0363317835777686,"ARIH2","ariadne RBR E3 ubiquitin protein ligase 2",TRUE
+"1559532_at",0.596382916302699,0.0727403196120984,-1.88409953717548,-4.34443034849603,-1.4267435004033,"ARIH2OS","ariadne homolog 2 opposite strand",TRUE
+"201658_at",0.683838837468118,0.15273065957916,-1.48083937377401,-4.92457205254162,-0.848454500856384,"ARL1","ADP ribosylation factor like GTPase 1",TRUE
+"201657_at",0.724590981430178,0.201833214466794,-1.31537782321576,-5.13036132125793,-0.678347751698421,"ARL1","ADP ribosylation factor like GTPase 1",TRUE
+"201659_s_at",0.767945391174396,0.270508929332377,-1.13012670869825,-5.33605175958635,-0.466200842895667,"ARL1","ADP ribosylation factor like GTPase 1",TRUE
+"1553208_s_at",0.262667888991006,0.00392980947772553,-3.21865401274104,-1.86024261669061,-1.44728007402022,"ARL10","ADP ribosylation factor like GTPase 10",TRUE
+"228843_at",0.489759595404215,0.02915715561117,2.33242775346783,-3.58904357835792,2.88122425511196,"ARL10","ADP ribosylation factor like GTPase 10",TRUE
+"1553207_at",0.658849897914525,0.126986012331472,1.58566160897978,-4.78405723635922,0.840768034484216,"ARL10","ADP ribosylation factor like GTPase 10",TRUE
+"239581_at",0.673296036410224,0.138858456452889,1.53533765160117,-4.85246831367225,1.18078328568041,"ARL10","ADP ribosylation factor like GTPase 10",TRUE
+"242411_at",0.97689149311934,0.889819891706736,0.140134431059116,-5.93012322512603,0.0444218057963255,"ARL10","ADP ribosylation factor like GTPase 10",TRUE
+"1552691_at",0.779826278199024,0.301033624648717,1.05894425975601,-5.40778704658034,1.68205738546269,"ARL11","ADP ribosylation factor like GTPase 11",TRUE
+"1552693_at",0.94960065125426,0.772139853736198,-0.293144302989359,-5.89791485693849,-0.285800529374797,"ARL11","ADP ribosylation factor like GTPase 11",TRUE
+"228201_at",0.896229101808264,0.579653259774236,0.562155708109325,-5.78692343355726,0.262223222232329,"ARL13B","ADP ribosylation factor like GTPase 13B",TRUE
+"220468_at",0.0090462147233415,4.13635789818999e-06,6.05754767328529,4.13625185749671,6.00008411260568,"ARL14","ADP ribosylation factor like GTPase 14",TRUE
+"226383_at",0.936992192746977,0.719105782468445,-0.364275350837984,-5.8752577549598,-0.130385604310048,"ARL14EP","ADP ribosylation factor like GTPase 14 effector protein",TRUE
+"219842_at",0.783297012796639,0.305819114157406,-1.04826093492377,-5.41819322245569,-0.359987440723644,"ARL15","ADP ribosylation factor like GTPase 15",TRUE
+"228151_at",0.789488409459128,0.316232464228217,-1.02541600164656,-5.44012673115551,-0.388043448356285,"ARL15","ADP ribosylation factor like GTPase 15",TRUE
+"234972_at",0.984802091612958,0.925451541096864,-0.0946398937329997,-5.93532193918656,-0.0342711538167109,"ARL16","ADP ribosylation factor like GTPase 16",TRUE
+"243899_at",0.630603891142543,0.101921817714832,1.70635373356204,-4.6130662431408,0.722303460498503,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"232991_at",0.841201473813125,0.431101331435642,0.801946703501468,-5.63120667910534,0.404656733082398,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"241910_x_at",0.86632010667518,0.497228921217628,0.690210112910125,-5.71027764616412,0.21146372232986,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"1554245_x_at",0.888756025960104,0.555570253288573,0.598508870705072,-5.76670127089153,0.229114062823475,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"232987_at",0.895690630367785,0.57622200730006,0.5672875301489,-5.78414314255278,0.310414324721479,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"1555964_at",0.91451110815108,0.6398650652459,-0.474388223226186,-5.83066321286714,-0.228233697711165,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"1555144_at",0.91876780831279,0.654501823207247,-0.453637308392442,-5.8399463279647,-0.347751996609579,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"229028_s_at",0.92856472663873,0.68583867134617,0.409867904367481,-5.85819050663774,0.194683997323339,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"1555794_at",0.957430653957785,0.80753491485433,-0.246538850356001,-5.91012238465162,-0.193958564353096,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"210435_at",0.989638901366417,0.950018273368903,-0.0633977315532881,-5.93772603096701,-0.0341311103765163,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"210718_s_at",0.996884495697612,0.983939127760798,0.020359119567763,-5.93948159814245,0.00750142678308752,"ARL17B///ARL17A","ADP ribosylation factor like GTPase 17B///ADP ribosylation factor like GTPase 17A",TRUE
+"202564_x_at",0.924696623416105,0.674255713761485,-0.425947019130865,-5.85169947307174,-0.191606380188396,"ARL2","ADP ribosylation factor like GTPase 2",TRUE
+"202091_at",0.833129975086556,0.410385740689778,0.839081242227058,-5.60246069214247,0.262564315953544,"ARL2BP","ADP ribosylation factor like GTPase 2 binding protein",TRUE
+"202092_s_at",0.838991915745708,0.42445679394018,-0.813733398555448,-5.6222146668735,-0.321101852755872,"ARL2BP","ADP ribosylation factor like GTPase 2 binding protein",TRUE
+"213433_at",0.784552021081681,0.307919121343702,-1.04361020571247,-5.42269367565104,-0.594649370089818,"ARL3","ADP ribosylation factor like GTPase 3",TRUE
+"202641_at",0.868397087637799,0.504004940723152,-0.679264706209338,-5.71741689254916,-0.378080025086174,"ARL3","ADP ribosylation factor like GTPase 3",TRUE
+"1568590_at",0.962555471240652,0.82951544537872,0.217881650989142,-5.9165878334937,0.0808221784873489,"ARL3","ADP ribosylation factor like GTPase 3",TRUE
+"205020_s_at",0.816199380744005,0.36719021381929,0.920569488398454,-5.53514271689953,0.548065944256029,"ARL4A","ADP ribosylation factor like GTPase 4A",TRUE
+"202206_at",0.606216348204496,0.0798863976006107,1.83552980356864,-4.41974172645085,1.70794790816185,"ARL4C","ADP ribosylation factor like GTPase 4C",TRUE
+"202208_s_at",0.632949074657601,0.104045522458341,1.69520882688004,-4.62925499343255,1.666897453375,"ARL4C","ADP ribosylation factor like GTPase 4C",TRUE
+"202207_at",0.639656559005154,0.110034922668833,1.66478487439874,-4.67303966266497,1.9281674808376,"ARL4C","ADP ribosylation factor like GTPase 4C",TRUE
+"213759_at",0.868362470085218,0.503021327271529,-0.680848361588072,-5.71639068824654,-0.43614056217119,"ARL4C","ADP ribosylation factor like GTPase 4C",TRUE
+"203586_s_at",0.812302873476553,0.35967025130303,0.935391517625195,-5.52227931302775,0.613776108087929,"ARL4D","ADP ribosylation factor like GTPase 4D",TRUE
+"203587_at",0.984791329585735,0.925226538969548,0.094926432631283,-5.93529549428124,0.0583486413720475,"ARL4D","ADP ribosylation factor like GTPase 4D",TRUE
+"226345_at",0.774230543658252,0.290320116547167,1.08330833987668,-5.38370172088206,0.350433922095229,"ARL5B","ADP ribosylation factor like GTPase 5B",TRUE
+"242727_at",0.828607509614823,0.398803120702832,0.860363433917327,-5.5854383520123,0.333375564264834,"ARL5B","ADP ribosylation factor like GTPase 5B",TRUE
+"1560136_at",0.635916735157933,0.107106382934479,1.67948076731638,-4.65196498671298,0.3918498461279,"ARL5C","ADP ribosylation factor like GTPase 5C",TRUE
+"223735_at",0.911271451158197,0.629248145716078,0.489572947599703,-5.82361284807199,0.184978464974435,"ARL6","ADP ribosylation factor like GTPase 6",TRUE
+"235320_at",0.960029104619887,0.819065373256214,-0.231481208346789,-5.91361855689154,-0.100693043100605,"ARL6","ADP ribosylation factor like GTPase 6",TRUE
+"211935_at",0.812302873476553,0.360523531284511,-0.933699309605904,-5.52375746030817,-0.29960016772988,"ARL6IP1","ADP ribosylation factor like GTPase 6 interacting protein 1",TRUE
+"218216_x_at",0.927034337839692,0.681300297449922,-0.416154615124278,-5.8556818418543,-0.135253106706758,"ARL6IP4","ADP ribosylation factor like GTPase 6 interacting protein 4",TRUE
+"220597_s_at",0.940456186612281,0.733616028514198,-0.344638465105946,-5.8819972341628,-0.110183186961983,"ARL6IP4","ADP ribosylation factor like GTPase 6 interacting protein 4",TRUE
+"200761_s_at",0.973433731874338,0.87151887000563,-0.16361323474763,-5.92665355087354,-0.0710999047798389,"ARL6IP5","ADP ribosylation factor like GTPase 6 interacting protein 5",TRUE
+"200760_s_at",0.973567634886313,0.872841023072509,0.161914017112136,-5.9269226221656,0.0630136444703844,"ARL6IP5","ADP ribosylation factor like GTPase 6 interacting protein 5",TRUE
+"225709_at",0.675662829199842,0.142271738347278,1.52152833756423,-4.8709354624159,0.485871116820342,"ARL6IP6","ADP ribosylation factor like GTPase 6 interacting protein 6",TRUE
+"225707_at",0.760227035076299,0.258158920213386,1.16059586354944,-5.30408568232885,0.44799217429987,"ARL6IP6","ADP ribosylation factor like GTPase 6 interacting protein 6",TRUE
+"225711_at",0.904381089098038,0.608022040678585,0.520289510455691,-5.80868809792968,0.201979683705188,"ARL6IP6","ADP ribosylation factor like GTPase 6 interacting protein 6",TRUE
+"225347_at",0.358427723880268,0.0101626173085935,-2.80981143908449,-2.68778519340518,-1.41635193111549,"ARL8A","ADP ribosylation factor like GTPase 8A",TRUE
+"222442_s_at",0.821962235882611,0.385231816379117,-0.885812446594067,-5.56456284976404,-0.274638677933137,"ARL8B","ADP ribosylation factor like GTPase 8B",TRUE
+"217852_s_at",0.841967750949524,0.434836071719946,-0.79537111581017,-5.63616958876344,-0.228488838095046,"ARL8B","ADP ribosylation factor like GTPase 8B",TRUE
+"229062_at",0.937462538530338,0.722733231722525,0.35935288826749,-5.87698180698792,0.418398717891291,"ARL9","ADP ribosylation factor like GTPase 9",TRUE
+"218185_s_at",0.907964244160782,0.618061170725126,-0.505700362925271,-5.81588721090142,-0.198568483101093,"ARMC1","armadillo repeat containing 1",TRUE
+"222550_at",0.919121059653789,0.655584247271174,-0.452110840407951,-5.84061314364384,-0.166299196116212,"ARMC1","armadillo repeat containing 1",TRUE
+"1554480_a_at",0.899836409534344,0.593768595942936,-0.541202211469157,-5.79802095278603,-0.197984952525674,"ARMC10","armadillo repeat containing 10",TRUE
+"223328_at",0.981557175782601,0.912304212981304,0.111397394184807,-5.93364113644493,0.0407821940138202,"ARMC10","armadillo repeat containing 10",TRUE
+"231263_at",0.993213867476782,0.967576166864815,-0.0411103050870695,-5.9388603497315,-0.0285060924852019,"ARMC12","armadillo repeat containing 12",TRUE
+"223866_at",0.975657122206595,0.88393907275236,-0.147669630632683,-5.92906800428655,-0.108729551496001,"ARMC2","armadillo repeat containing 2",TRUE
+"202961_s_at",0.909441642299191,0.623955276372186,-0.497186610365824,-5.81999608062202,-0.152085166884238,"ARMC2-AS1///ATP5J2","ARMC2 antisense RNA 1///ATP synthase, H+ transporting, mitochondrial Fo complex subunit F2",TRUE
+"240275_at",0.885029460971826,0.546094697058077,0.613035475778734,-5.75827829817857,0.486288041680937,"ARMC3","armadillo repeat containing 3",TRUE
+"223794_at",0.853399486996397,0.461696350963182,0.749066191083182,-5.6700263053425,0.863175178412915,"ARMC4","armadillo repeat containing 4",TRUE
+"221077_at",0.89085645983207,0.559932002599526,0.591865637079087,-5.77048820737307,0.193929152859725,"ARMC4","armadillo repeat containing 4",TRUE
+"227738_s_at",0.549127954108835,0.0486115174507002,2.08690139887396,-4.01552214626927,0.535892928809349,"ARMC5","armadillo repeat containing 5",TRUE
+"221758_at",0.982243328340126,0.914408724180865,-0.108712927880091,-5.9339287637492,-0.0394555459102133,"ARMC6","armadillo repeat containing 6",TRUE
+"219096_at",0.896139457361073,0.578652692863281,-0.563650586879108,-5.78611607513817,-0.236050853105645,"ARMC7","armadillo repeat containing 7",TRUE
+"229906_at",0.924874199396311,0.675022444047953,-0.424879178423274,-5.85213816409153,-0.251443305665618,"ARMC7","armadillo repeat containing 7",TRUE
+"203487_s_at",0.552420073963858,0.049931887273175,-2.07369502378501,-4.03761821634373,-0.703158492618007,"ARMC8","armadillo repeat containing 8",TRUE
+"203486_s_at",0.755049574909504,0.24871282423116,-1.18463759376736,-5.2783367911792,-0.300364368133735,"ARMC8","armadillo repeat containing 8",TRUE
+"219094_at",0.816800680706682,0.368981586039657,0.917068585338505,-5.53815338077621,0.317104348614097,"ARMC8","armadillo repeat containing 8",TRUE
+"1555281_x_at",0.852855949428146,0.458973003393611,0.753685568722761,-5.66673493077652,0.315329028590749,"ARMC8","armadillo repeat containing 8",TRUE
+"1555279_at",0.942324052902057,0.740969302956246,0.334740175269551,-5.88525445579202,0.13227946428233,"ARMC8","armadillo repeat containing 8",TRUE
+"236966_at",0.971216837324271,0.86194687365374,-0.17593011554262,-5.92461942664738,-0.16607516020527,"ARMC8","armadillo repeat containing 8",TRUE
+"220754_at",0.678611044120554,0.146112299251818,-1.50631162738012,-4.89113060169095,-1.2349195263371,"ARMC9","armadillo repeat containing 9",TRUE
+"240639_at",0.735677568529031,0.220726736299248,-1.26014877117065,-5.19449063842069,-0.797274086744342,"ARMC9","armadillo repeat containing 9",TRUE
+"219636_s_at",0.930425569308785,0.692318307017637,-0.400921050858547,-5.86169588396447,-0.251970566630434,"ARMC9","armadillo repeat containing 9",TRUE
+"1568691_at",0.955645941042265,0.797044546089955,-0.260288947181477,-5.90673855866618,-0.147279804035171,"ARMC9","armadillo repeat containing 9",TRUE
+"235938_at",0.980434477155705,0.908584154074312,-0.116144680947115,-5.93311533540031,-0.106597732867885,"ARMC9","armadillo repeat containing 9",TRUE
+"219637_at",0.997890350692744,0.990206549364136,-0.0124138332318658,-5.9396084230138,-0.008552712288596,"ARMC9","armadillo repeat containing 9",TRUE
+"218694_at",0.874834820370747,0.521644388860115,-0.65115305935599,-5.73525212433764,-0.793666869006054,"ARMCX1","armadillo repeat containing, X-linked 1",TRUE
+"203404_at",0.853152340349922,0.459617781161535,0.752590410187884,-5.66751697991711,1.33292727422444,"ARMCX2","armadillo repeat containing, X-linked 2",TRUE
+"217858_s_at",0.876632890672003,0.525510425397123,-0.645062454353696,-5.73902096290737,-0.250288926861641,"ARMCX3","armadillo repeat containing, X-linked 3",TRUE
+"222444_at",0.964685626382167,0.836631354756256,-0.208645272005379,-5.91850245036177,-0.090569962811827,"ARMCX3","armadillo repeat containing, X-linked 3",TRUE
+"1564399_a_at",0.697412165374288,0.167916973089708,1.42561316789027,-4.99548714102516,0.816539676321788,"ARMCX4","armadillo repeat containing, X-linked 4",TRUE
+"1557726_at",0.807944276806637,0.349574161986192,0.955622322542054,-5.50441757713565,0.585365931855605,"ARMCX4","armadillo repeat containing, X-linked 4",TRUE
+"227444_at",0.817511349657198,0.369902391937255,-0.915273438692187,-5.53969304824765,-1.2090203305155,"ARMCX4","armadillo repeat containing, X-linked 4",TRUE
+"207799_x_at",0.92247975200053,0.668656884334309,0.433760000924091,-5.84845682728124,0.263667545946786,"ARMCX4","armadillo repeat containing, X-linked 4",TRUE
+"1552327_at",0.997608949249317,0.987824811929891,-0.0154330657610515,-5.93956747295293,-0.0160591824439833,"ARMCX4","armadillo repeat containing, X-linked 4",TRUE
+"1555902_at",0.917654257398946,0.65072470440996,-0.458972532247733,-5.83759840641836,-0.222452565887228,"ARMCX5","armadillo repeat containing, X-linked 5",TRUE
+"219335_at",0.990797621966014,0.95336464064625,-0.0591477756450354,-5.93797965382802,-0.0290128916208463,"ARMCX5","armadillo repeat containing, X-linked 5",TRUE
+"228027_at",0.812302873476553,0.360072629660834,0.934593193523528,-5.52297695723857,0.686560752628205,"ARMCX5-GPRASP2///GPRASP2","ARMCX5-GPRASP2 readthrough///G protein-coupled receptor associated sorting protein 2",TRUE
+"214749_s_at",0.650298942402444,0.120473305671593,-1.61495020464363,-4.7434490240521,-0.64448415372927,"ARMCX6","armadillo repeat containing, X-linked 6",TRUE
+"215727_x_at",0.962555471240652,0.829302072552565,0.218158902253893,-5.91652908568268,0.131261988199149,"ARMCX6","armadillo repeat containing, X-linked 6",TRUE
+"218195_at",0.722937902375896,0.199627184655174,-1.32208469550286,-5.12241499799436,-0.779857548720342,"ARMT1","acidic residue methyltransferase 1",TRUE
+"233724_at",0.64513208805899,0.115782194639787,-1.63687834335529,-4.71266999362109,-0.902919799360263,"ARNT","aryl hydrocarbon receptor nuclear translocator",TRUE
+"233714_at",0.683017520100356,0.151431876193506,1.48576609854159,-4.91813974719245,0.87714963230684,"ARNT","aryl hydrocarbon receptor nuclear translocator",TRUE
+"230619_at",0.753004442639617,0.246360191494055,-1.19073108001442,-5.27173741269039,-0.39606341150158,"ARNT","aryl hydrocarbon receptor nuclear translocator",TRUE
+"210828_s_at",0.820611742812032,0.380986058916166,0.893893782354431,-5.557815808896,0.49960502846924,"ARNT","aryl hydrocarbon receptor nuclear translocator",TRUE
+"218222_x_at",0.877333806479767,0.52709467078934,-0.642573699355948,-5.74055120216084,-0.391595651851524,"ARNT","aryl hydrocarbon receptor nuclear translocator",TRUE
+"231016_s_at",0.942199057522921,0.739850945825076,-0.33624338104416,-5.88476584269691,-0.115908947270416,"ARNT","aryl hydrocarbon receptor nuclear translocator",TRUE
+"218221_at",0.976430946628033,0.888101226243538,-0.14233570918211,-5.92982066247266,-0.0541933721531116,"ARNT","aryl hydrocarbon receptor nuclear translocator",TRUE
+"202986_at",0.930083070178974,0.691502919010858,-0.402045065119195,-5.86125967791989,-0.651538783385907,"ARNT2","aryl hydrocarbon receptor nuclear translocator 2",TRUE
+"210971_s_at",0.943464796017993,0.747128757872613,0.32647510331805,-5.88790229584937,0.163459156688424,"ARNTL","aryl hydrocarbon receptor nuclear translocator like",TRUE
+"209824_s_at",0.979883160726582,0.904054804205207,-0.121928434177966,-5.93244512884555,-0.0516659192340256,"ARNTL","aryl hydrocarbon receptor nuclear translocator like",TRUE
+"224204_x_at",0.0533112880354026,8.1741739509581e-05,4.81163756592755,1.5488687417994,5.31160299716377,"ARNTL2","aryl hydrocarbon receptor nuclear translocator like 2",TRUE
+"223586_at",0.0550194051692779,9.68223059005957e-05,4.74230551130473,1.40032665680592,4.340315780864,"ARNTL2","aryl hydrocarbon receptor nuclear translocator like 2",TRUE
+"220658_s_at",0.111201883761006,0.000553212846511085,4.03074528122341,-0.134361249700667,5.1631261797727,"ARNTL2","aryl hydrocarbon receptor nuclear translocator like 2",TRUE
+"1563101_at",0.655925300030246,0.124358878099927,1.59732198537543,-4.76795953095818,1.42856068233149,"ARNTL2-AS1","ARNTL2 antisense RNA 1",TRUE
+"200950_at",0.994304286761558,0.974172693795028,0.0327430188953532,-5.93916131128334,0.0135770654965324,"ARPC1A","actin related protein 2/3 complex subunit 1A",TRUE
+"201954_at",0.695812999227098,0.165969859962197,1.43246299672132,-4.98681077001065,0.933486587788655,"ARPC1B","actin related protein 2/3 complex subunit 1B",TRUE
+"207988_s_at",0.71278153948281,0.186785550907795,1.36232213100336,-5.07402949503164,0.326973273260561,"ARPC2","actin related protein 2/3 complex subunit 2",TRUE
+"208679_s_at",0.843753336849204,0.439354556484007,0.787462033372804,-5.64208801678294,0.211660638320367,"ARPC2","actin related protein 2/3 complex subunit 2",TRUE
+"213513_x_at",0.876953995372682,0.526060121449167,0.64419845098584,-5.73955284917284,0.139813158183111,"ARPC2","actin related protein 2/3 complex subunit 2",TRUE
+"208736_at",0.653375957820821,0.122719751187268,-1.6047015572284,-4.75772427788739,-0.398047574065245,"ARPC3","actin related protein 2/3 complex subunit 3",TRUE
+"217817_at",0.60427479779745,0.078547434621792,-1.84433410794397,-4.40619368701273,-0.530272045950781,"ARPC4","actin related protein 2/3 complex subunit 4",TRUE
+"217818_s_at",0.819203514175924,0.375941004231575,-0.903573731877982,-5.54965948836745,-0.676640590881556,"ARPC4","actin related protein 2/3 complex subunit 4",TRUE
+"211672_s_at",0.929139752786243,0.688506576756006,-0.406180073718136,-5.85964462301786,-0.159850024258088,"ARPC4-TTLL3///ARPC4","ARPC4-TTLL3 readthrough///actin related protein 2/3 complex subunit 4",TRUE
+"203670_at",0.784925710185113,0.309967771314638,1.03909477962002,-5.42704596926145,0.687891475580823,"ARPC4-TTLL3///TTLL3///ARPC4","ARPC4-TTLL3 readthrough///tubulin tyrosine ligase like 3///actin related protein 2/3 complex subunit 4",TRUE
+"230872_s_at",0.841641983271935,0.433512968137252,0.797696635191161,-5.63441879919992,0.743046191367536,"ARPC4-TTLL3///TTLL3///ARPC4","ARPC4-TTLL3 readthrough///tubulin tyrosine ligase like 3///actin related protein 2/3 complex subunit 4",TRUE
+"210129_s_at",0.84571977676742,0.443502231753052,0.780245843576744,-5.64743934087245,0.441984028793285,"ARPC4-TTLL3///TTLL3///ARPC4","ARPC4-TTLL3 readthrough///tubulin tyrosine ligase like 3///actin related protein 2/3 complex subunit 4",TRUE
+"1555797_a_at",0.643082025527735,0.113386969620968,1.64836362958745,-4.69642166102576,0.579993844877857,"ARPC5","actin related protein 2/3 complex subunit 5",TRUE
+"211963_s_at",0.744573608322482,0.235600620365259,1.21916951797062,-5.24054907869661,0.368476554978624,"ARPC5","actin related protein 2/3 complex subunit 5",TRUE
+"1569325_at",0.835838027302116,0.415344786275691,0.830086285778065,-5.60953550320553,0.306425600726049,"ARPC5","actin related protein 2/3 complex subunit 5",TRUE
+"226914_at",0.657015752622694,0.125353032901352,-1.59288558154576,-4.77409502966161,-0.684291062038801,"ARPC5L","actin related protein 2/3 complex subunit 5 like",TRUE
+"223101_s_at",0.743323328391634,0.233420621199328,-1.22505033004284,-5.23402006293718,-0.500809993009144,"ARPC5L","actin related protein 2/3 complex subunit 5 like",TRUE
+"220966_x_at",0.849057110178913,0.449740154876845,-0.76947012456357,-5.65534380381024,-0.282981600114304,"ARPC5L","actin related protein 2/3 complex subunit 5 like",TRUE
+"226915_s_at",0.85737998591191,0.472716207337854,-0.730537799510647,-5.68303522307865,-0.260758744116988,"ARPC5L","actin related protein 2/3 complex subunit 5 like",TRUE
+"228791_at",0.825648186672984,0.393259525204288,0.870689959411046,-5.57703578552413,0.96165684530907,"ARPIN","actin-related protein 2/3 complex inhibitor",TRUE
+"228666_at",0.839519981963042,0.427502021281748,0.808317342979305,-5.62636184343355,0.369501433760878,"ARPIN","actin-related protein 2/3 complex inhibitor",TRUE
+"217548_at",0.843753336849204,0.439440432989636,0.78731220191433,-5.64219959938524,0.363066687060369,"ARPIN","actin-related protein 2/3 complex inhibitor",TRUE
+"214553_s_at",0.55074985379986,0.0490140051289281,-2.08284197995277,-4.02232376478807,-0.676304969729429,"ARPP19","cAMP regulated phosphoprotein 19",TRUE
+"221482_s_at",0.690381347688918,0.160027074289962,-1.4537771367091,-4.95959601983267,-0.448855462194224,"ARPP19","cAMP regulated phosphoprotein 19",TRUE
+"221483_s_at",0.732320150624823,0.216703290020492,-1.27159531208783,-5.18139204365971,-0.426099849461368,"ARPP19","cAMP regulated phosphoprotein 19",TRUE
+"220359_s_at",0.73005042632231,0.212570159667027,-1.28352537618598,-5.16763255399586,-0.912557671396048,"ARPP21","cAMP regulated phosphoprotein 21",TRUE
+"1552722_at",0.883154480220886,0.540948330873557,0.620981041400402,-5.75358881074461,0.464071022825031,"ARPP21","cAMP regulated phosphoprotein 21",TRUE
+"1556598_at",0.925511384407886,0.678146800689844,-0.420532996758663,-5.85391249817279,-0.419028497845459,"ARPP21","cAMP regulated phosphoprotein 21",TRUE
+"231935_at",0.948429371744093,0.765109980925594,-0.302476749716763,-5.89521899707641,-0.225357221920727,"ARPP21","cAMP regulated phosphoprotein 21",TRUE
+"1560018_at",0.971242929121865,0.863589745042344,0.173814204056736,-5.92497933646061,0.147270803910098,"ARPP21","cAMP regulated phosphoprotein 21",TRUE
+"1556599_s_at",0.977189201833945,0.891167955772185,-0.138408318284278,-5.93035718447934,-0.134045746178579,"ARPP21","cAMP regulated phosphoprotein 21",TRUE
+"207136_at",0.606032418428309,0.0795627614743392,1.83764604548808,-4.41648948896781,0.616609092675859,"ARR3","arrestin 3",TRUE
+"221861_at",0.131554208455398,0.000818078296750534,-3.87056848422302,-0.479480355454103,-2.33037247961156,"ARRB1","arrestin beta 1",TRUE
+"43511_s_at",0.280199223932988,0.00458419653753171,-3.15335600827031,-1.99502899773231,-1.69620372960537,"ARRB1","arrestin beta 1",TRUE
+"49111_at",0.308861881799719,0.0063999072551017,-3.01070934192952,-2.28627140112489,-1.83484843225541,"ARRB1","arrestin beta 1",TRUE
+"222756_s_at",0.500677386446044,0.0319308445952192,-2.28959130686637,-3.66549453352989,-0.853302961115792,"ARRB1","arrestin beta 1",TRUE
+"222912_at",0.527546822913581,0.0399828833914932,-2.18213104309524,-3.85355911594565,-1.20977410486889,"ARRB1","arrestin beta 1",TRUE
+"228444_at",0.707898177720919,0.179845544562012,-1.38498322993727,-5.0462470302402,-1.37093854530274,"ARRB1","arrestin beta 1",TRUE
+"218832_x_at",0.711796119442521,0.18525576185948,-1.36725935779264,-5.06800896354948,-1.24191492664123,"ARRB1","arrestin beta 1",TRUE
+"203388_at",0.212348514754308,0.0025283746338373,3.40401148664643,-1.47334852698496,1.2382138380374,"ARRB2","arrestin beta 2",TRUE
+"226405_s_at",0.673322568613087,0.138910168245388,-1.53512636658319,-4.85275186267288,-1.0175241837439,"ARRDC1","arrestin domain containing 1",TRUE
+"234607_at",0.820536502908875,0.380759300210874,-0.89432704941272,-5.55745247559169,-0.721185382012688,"ARRDC1","arrestin domain containing 1",TRUE
+"223390_at",0.760244814241272,0.258475237921133,1.15980217928593,-5.30492783919531,0.876366292300395,"ARRDC1-AS1","ARRDC1 antisense RNA 1",TRUE
+"226055_at",0.891420607788025,0.561005486422522,0.590234773931896,-5.77141162506434,0.254512459906778,"ARRDC2","arrestin domain containing 2",TRUE
+"224797_at",0.943294768503521,0.745208603273401,-0.329049150143569,-5.88708468472533,-0.147662529463547,"ARRDC3","arrestin domain containing 3",TRUE
+"239395_at",0.865885012497452,0.496283678829433,0.691743693972463,-5.70926864627383,0.195806424763224,"ARRDC3-AS1","ARRDC3 antisense RNA 1",TRUE
+"225283_at",0.800053470634826,0.335471602643817,0.984557057930796,-5.47826428804815,0.954384060104063,"ARRDC4","arrestin domain containing 4",TRUE
+"236541_at",0.497725944448536,0.0305618824763572,-2.31028736168641,-3.62866044313919,-1.37379285191586,"ARSA","arylsulfatase A",TRUE
+"204443_at",0.990918916504081,0.957180845042002,0.0543024743724044,-5.93824735114913,0.0366343253931811,"ARSA","arylsulfatase A",TRUE
+"1554030_at",0.702809964629668,0.174659407906344,1.40237506422757,-5.02466716489989,0.496512464488229,"ARSB","arylsulfatase B",TRUE
+"232197_x_at",0.755598961025524,0.249575291256103,-1.18241453854888,-5.28073705626881,-0.629691264582353,"ARSB","arylsulfatase B",TRUE
+"206129_s_at",0.776983560547865,0.296044753415498,-1.07021114691927,-5.39670998462022,-0.422513777788426,"ARSB","arylsulfatase B",TRUE
+"1554032_at",0.979452359556342,0.901096170791835,-0.125708749926683,-5.93198950305495,-0.0422060191928946,"ARSB","arylsulfatase B",TRUE
+"230131_x_at",0.552218043161514,0.0494294486187919,-2.07868311749577,-4.02928312340962,-1.14379317293359,"ARSD","arylsulfatase D",TRUE
+"232423_at",0.565795244949651,0.0566567823837775,-2.01092229976741,-4.14138698452156,-1.59591162048096,"ARSD","arylsulfatase D",TRUE
+"225286_at",0.58935212773312,0.0678226536387159,-1.92000760559844,-4.2878651808277,-1.70664833638577,"ARSD","arylsulfatase D",TRUE
+"223696_at",0.617775129514679,0.0886798371043067,-1.78069296548856,-4.50307095392916,-1.70330537834379,"ARSD","arylsulfatase D",TRUE
+"225280_x_at",0.69097068180963,0.160687175331303,-1.45137844021028,-4.96267512156077,-0.896525791756854,"ARSD","arylsulfatase D",TRUE
+"223695_s_at",0.71242055183987,0.186548294281763,-1.36308575325583,-5.07309950918656,-1.31092060412811,"ARSD","arylsulfatase D",TRUE
+"206831_s_at",0.803111243433434,0.340852302366926,-0.973420901618016,-5.48841420251473,-0.834158521953826,"ARSD","arylsulfatase D",TRUE
+"207784_at",0.879960488971225,0.535138326192377,0.629999902006228,-5.74819538375558,0.284362632485712,"ARSD","arylsulfatase D",TRUE
+"205894_at",0.719412173140763,0.195437279102834,-1.33498408318794,-5.10703609058158,-0.773030475559117,"ARSE","arylsulfatase E (chondrodysplasia punctata 1)",TRUE
+"214490_at",0.737897493665289,0.224642044482099,1.24916237560817,-5.20696720175277,0.750504935036441,"ARSF","arylsulfatase F",TRUE
+"230856_at",0.495146831905934,0.0301661471802225,-2.31642855031825,-3.61769356587806,-2.14919270840717,"ARSG","arylsulfatase G",TRUE
+"1552632_a_at",0.79782885150643,0.331426726612597,-0.993009704028492,-5.47049008627005,-0.915531263795359,"ARSG","arylsulfatase G",TRUE
+"230275_at",0.109433493286707,0.000532210365144726,4.04656658559839,-0.100217454103253,3.61721474311663,"ARSI","arylsulfatase family member I",TRUE
+"219973_at",0.951102506952277,0.776661407000777,0.287155822666749,-5.89960061500804,0.322211026114314,"ARSJ","arylsulfatase family member J",TRUE
+"1569133_x_at",0.750491299232222,0.243437827012043,-1.19836121820264,-5.26343224098082,-0.672408445300678,"ARSK","arylsulfatase family member K",TRUE
+"1569132_s_at",0.915353407558177,0.642843986584563,0.470148060652914,-5.83259313383349,0.167464060089195,"ARSK","arylsulfatase family member K",TRUE
+"239147_at",0.945498722604777,0.754348713047504,0.316816395765969,-5.89091357306822,0.172548751405547,"ARSK","arylsulfatase family member K",TRUE
+"1570479_at",0.846898808963473,0.445474441059014,0.776829029350177,-5.6499569524011,0.25225161016211,"ART1","ADP-ribosyltransferase 1",TRUE
+"1570480_s_at",0.914548427579679,0.639991538868333,-0.474208023180386,-5.8307455763906,-0.224537835030773,"ART1","ADP-ribosyltransferase 1",TRUE
+"207919_at",0.986984564305792,0.939995614678211,0.0761341993250704,-5.93686065438624,0.028137702433872,"ART1","ADP-ribosyltransferase 1",TRUE
+"210147_at",0.849935057946582,0.451693535644197,-0.766114421876239,-5.65778416593828,-0.972747496164631,"ART3","ADP-ribosyltransferase 3",TRUE
+"207220_at",0.818593126679085,0.371905792475124,-0.91137795615224,-5.54302456937395,-0.385852936866454,"ART4","ADP-ribosyltransferase 4 (Dombrock blood group)",TRUE
+"242496_at",0.819807973515613,0.377878621945408,-0.899845968955789,-5.55281011675041,-0.57094689202021,"ART4","ADP-ribosyltransferase 4 (Dombrock blood group)",TRUE
+"1552524_at",0.854163696308241,0.463827251612797,0.74546306209733,-5.67258028150609,0.252491821659461,"ART5","ADP-ribosyltransferase 5",TRUE
+"210237_at",0.235987808934097,0.003055864082768,3.32464067911128,-1.6397376319999,2.26378743502365,"ARTN","artemin",TRUE
+"207675_x_at",0.429170076412192,0.0187142952490225,2.53722132260468,-3.21279101806043,1.05750826786642,"ARTN","artemin",TRUE
+"216052_x_at",0.554323039614776,0.0507331045309985,2.06583295853847,-4.05072930070756,1.82472643134618,"ARTN","artemin",TRUE
+"223223_at",0.796963640275795,0.329946323519317,-0.996121130241184,-5.46761318694159,-0.369753505828008,"ARV1","ARV1 homolog, fatty acid homeostasis modulator",TRUE
+"238140_at",0.897024165042344,0.583000999025703,0.557163450584764,-5.78960459365235,0.221113155119113,"ARV1","ARV1 homolog, fatty acid homeostasis modulator",TRUE
+"217516_x_at",0.865561991774564,0.495495652136298,0.693023478234061,-5.70842499209949,0.466958611382945,"ARVCF","armadillo repeat gene deleted in velocardiofacial syndrome",TRUE
+"1556149_at",0.89316156038085,0.566976903316716,0.581192097627885,-5.77648699411796,0.255364689796346,"ARVCF","armadillo repeat gene deleted in velocardiofacial syndrome",TRUE
+"205784_x_at",0.973071267819624,0.870113811762513,-0.165419542035401,-5.92636444973228,-0.0990261051574466,"ARVCF","armadillo repeat gene deleted in velocardiofacial syndrome",TRUE
+"238878_at",0.821745015752602,0.384680249650857,-0.886858988788162,-5.56369229976953,-1.0760815482497,"ARX","aristaless related homeobox",TRUE
+"231020_at",0.973936963444057,0.87390198683973,0.160550830389221,-5.92713645732266,0.0928640257442535,"ARX","aristaless related homeobox",TRUE
+"223652_at",0.629843125032519,0.100712411845313,1.71278906723049,-4.60368224156635,1.32900867590152,"AS3MT","arsenite methyltransferase",TRUE
+"213902_at",0.712948021516228,0.187042481787852,1.36149604926436,-5.07503505835961,0.525300608546461,"ASAH1","N-acylsphingosine amidohydrolase 1",TRUE
+"213702_x_at",0.858994261239434,0.475386084447079,-0.726087251546791,-5.68611391346563,-0.348973019415059,"ASAH1","N-acylsphingosine amidohydrolase 1",TRUE
+"210980_s_at",0.867692227847244,0.500554328105956,-0.684828040793383,-5.71380178323095,-0.376994890939061,"ASAH1","N-acylsphingosine amidohydrolase 1",TRUE
+"1555419_a_at",0.888777794593349,0.555713100591914,-0.598290875546862,-5.76682618582575,-0.330233395442008,"ASAH1","N-acylsphingosine amidohydrolase 1",TRUE
+"210979_at",0.937232018318296,0.721472348252962,-0.361062880060625,-5.87638552192882,-0.349696203962499,"ASAH1","N-acylsphingosine amidohydrolase 1",TRUE
+"231791_at",0.818686885011389,0.372320976603716,-0.910572399194606,-5.5437118675674,-0.499967826296828,"ASAH2B","N-acylsphingosine amidohydrolase 2B",TRUE
+"229793_at",0.833285547058304,0.41064697480561,-0.838605689459998,-5.60283651307676,-0.363373045759985,"ASAH2B","N-acylsphingosine amidohydrolase 2B",TRUE
+"221039_s_at",0.547369367321334,0.0479542619015855,2.09359564233078,-4.00428719490384,1.3230252017568,"ASAP1","ArfGAP with SH3 domain, ankyrin repeat and PH domain 1",TRUE
+"236533_at",0.56861088242915,0.0585960705386336,1.99405500638387,-4.1689089479902,0.892308376434354,"ASAP1","ArfGAP with SH3 domain, ankyrin repeat and PH domain 1",TRUE
+"224796_at",0.624374299616567,0.095937238062712,1.73885958221251,-4.56539677346777,1.0538032040733,"ASAP1","ArfGAP with SH3 domain, ankyrin repeat and PH domain 1",TRUE
+"224790_at",0.6287528932499,0.0998830396586975,1.71724035131236,-4.59717591707868,1.04411234474,"ASAP1","ArfGAP with SH3 domain, ankyrin repeat and PH domain 1",TRUE
+"224791_at",0.725836505745628,0.204857190962131,1.30627636577374,-5.14109013038921,0.765560196688641,"ASAP1","ArfGAP with SH3 domain, ankyrin repeat and PH domain 1",TRUE
+"220694_at",0.895089656985852,0.57262818513125,0.572679048653495,-5.78119577587431,0.398752009657122,"ASAP1-IT1","ASAP1 intronic transcript 1",TRUE
+"1557685_at",0.90344422113846,0.604467975000622,0.525481744045843,-5.80607782562744,0.384739108327161,"ASAP1-IT2","ASAP1 intronic transcript 2",TRUE
+"206414_s_at",0.647518308302168,0.118750179741122,1.62292025836121,-4.73229903114891,0.62250110339634,"ASAP2","ArfGAP with SH3 domain, ankyrin repeat and PH domain 2",TRUE
+"219103_at",0.457495355970503,0.0227178763870126,-2.44849483827599,-3.37790188173568,-1.53374535425805,"ASAP3","ArfGAP with SH3 domain, ankyrin repeat and PH domain 3",TRUE
+"222236_s_at",0.463390171100414,0.0235784445542085,-2.43133963126892,-3.40946467968911,-1.66995969138088,"ASAP3","ArfGAP with SH3 domain, ankyrin repeat and PH domain 3",TRUE
+"238991_at",0.831957210365167,0.40807795212905,0.843290742061074,-5.59912532394102,0.615807495346677,"ASB1","ankyrin repeat and SOCS box containing 1",TRUE
+"212818_s_at",0.856545578149517,0.470500838565422,-0.73424194531371,-5.68045923842529,-0.213743734770636,"ASB1","ankyrin repeat and SOCS box containing 1",TRUE
+"212819_at",0.862779849418027,0.48643326776335,0.707825717554229,-5.69855904126022,0.283588446723351,"ASB1","ankyrin repeat and SOCS box containing 1",TRUE
+"1564536_at",0.736256800969852,0.221736613181976,1.25730086468521,-5.19773382221315,0.707201411976622,"ASB10","ankyrin repeat and SOCS box containing 10",TRUE
+"1564537_a_at",0.768852835478002,0.273565943869136,1.122742976366,-5.34368529805874,0.576858994203858,"ASB10","ankyrin repeat and SOCS box containing 10",TRUE
+"1553039_a_at",0.869380945553245,0.506411085073149,0.675398049569126,-5.71991287095022,0.306880660478535,"ASB10","ankyrin repeat and SOCS box containing 10",TRUE
+"1553074_at",0.887083096014278,0.551381073864417,-0.604914943459011,-5.76301086328143,-0.473139536672141,"ASB11","ankyrin repeat and SOCS box containing 11",TRUE
+"236033_at",0.990810941805126,0.955306208919461,-0.0566824604462251,-5.93811871612941,-0.0235600705930912,"ASB12","ankyrin repeat and SOCS box containing 12",TRUE
+"221390_s_at",0.729083413548563,0.210877195041608,1.28846371946321,-5.16190491207424,0.855389780686225,"ASB12///MTMR8","ankyrin repeat and SOCS box containing 12///myotubularin related protein 8",TRUE
+"220537_at",0.831893282610777,0.407842086680563,0.843721822524165,-5.59878288072531,0.52823945224868,"ASB12///MTMR8","ankyrin repeat and SOCS box containing 12///myotubularin related protein 8",TRUE
+"218862_at",0.783061975680449,0.305572725914235,-1.04880807361271,-5.41766258044862,-0.529043733459778,"ASB13","ankyrin repeat and SOCS box containing 13",TRUE
+"237785_at",0.739367922105944,0.227292152594715,1.24180888690481,-5.2152656678706,0.982745435909895,"ASB14","ankyrin repeat and SOCS box containing 14",TRUE
+"1553453_at",0.979588787486838,0.902112461190909,-0.12441000297861,-5.9321476019255,-0.0581791154357392,"ASB14","ankyrin repeat and SOCS box containing 14",TRUE
+"1564679_at",0.734913444725244,0.219956536067378,1.2623274952871,-5.1920052735524,0.677446534135044,"ASB15","ankyrin repeat and SOCS box containing 15",TRUE
+"1553253_at",0.822010986888098,0.38570123581877,-0.884922541359598,-5.56530235424769,-0.463274672156567,"ASB16","ankyrin repeat and SOCS box containing 16",TRUE
+"1555981_at",0.852064935533376,0.457551467896844,0.756103315288237,-5.66500461512862,0.258135502975014,"ASB16-AS1","ASB16 antisense RNA 1",TRUE
+"231622_at",0.809930331505913,0.35359044280809,0.947527739405275,-5.51160631812195,0.504239387507372,"ASB17","ankyrin repeat and SOCS box containing 17",TRUE
+"227915_at",0.554454260421586,0.0508363823958557,2.06482762844723,-4.05240349126544,1.27432591320675,"ASB2","ankyrin repeat and SOCS box containing 2",TRUE
+"233857_s_at",0.971826767527606,0.865096029590169,-0.171874921232929,-5.92530538866001,-0.165264560300336,"ASB2","ankyrin repeat and SOCS box containing 2",TRUE
+"1560219_at",0.751464513744428,0.244682963651127,1.19510187871475,-5.26698558029694,0.637304932324833,"ASB3","ankyrin repeat and SOCS box containing 3",TRUE
+"235619_at",0.468732760220321,0.0247767816765479,2.40839326450548,-3.45149324790564,1.52332448458074,"ASB4","ankyrin repeat and SOCS box containing 4",TRUE
+"237720_at",0.639705117673934,0.110237660590446,1.6637797833847,-4.67447587316387,1.0612664133695,"ASB4","ankyrin repeat and SOCS box containing 4",TRUE
+"208481_at",0.683019114815084,0.151678366827011,1.48482843996606,-4.9193652755718,0.817760839200155,"ASB4","ankyrin repeat and SOCS box containing 4",TRUE
+"237721_s_at",0.884338493988207,0.543452334810788,-0.617110065728166,-5.75588073890742,-0.435065954778473,"ASB4","ankyrin repeat and SOCS box containing 4",TRUE
+"217229_at",0.916340239998123,0.646554721137876,-0.464878439683856,-5.83496797346968,-0.311023758856508,"ASB4","ankyrin repeat and SOCS box containing 4",TRUE
+"217228_s_at",0.936599157163462,0.717030924608791,0.367095061228603,-5.8742597428921,0.277541751559539,"ASB4","ankyrin repeat and SOCS box containing 4",TRUE
+"235503_at",0.819018525257656,0.374396479424525,0.906554317224891,-5.54713170207256,0.862454431036352,"ASB5","ankyrin repeat and SOCS box containing 5",TRUE
+"222524_s_at",0.258009532763673,0.00381706158873278,-3.23095981386941,-1.83474674751758,-1.29006104790987,"ASB6","ankyrin repeat and SOCS box containing 6",TRUE
+"221657_s_at",0.814991286978568,0.365831217709019,-0.923232987930418,-5.53284511594242,-0.269304097016615,"ASB6","ankyrin repeat and SOCS box containing 6",TRUE
+"226513_at",0.780614263830306,0.302172374915153,-1.05639118537532,-5.41028250051,-0.34626429384449,"ASB7","ankyrin repeat and SOCS box containing 7",TRUE
+"219996_at",0.979803152416153,0.903868120967033,-0.12216690938319,-5.93241679690803,-0.0426801934700132,"ASB7","ankyrin repeat and SOCS box containing 7",TRUE
+"218841_at",0.314676324477256,0.00672805895407248,-2.98917788673747,-2.32981630788046,-0.923590688410102,"ASB8","ankyrin repeat and SOCS box containing 8",TRUE
+"226861_at",0.527546822913581,0.0402339415649208,-2.17910843379729,-3.85876930312214,-0.908667382442648,"ASB8","ankyrin repeat and SOCS box containing 8",TRUE
+"205673_s_at",0.653206225743412,0.122643966685154,1.60504473404509,-4.75724741010456,1.2126739158431,"ASB9","ankyrin repeat and SOCS box containing 9",TRUE
+"1554627_a_at",0.610455440146151,0.0831271945816716,1.81473874413497,-4.45155031191677,0.713021578510702,"ASCC1","activating signal cointegrator 1 complex subunit 1",TRUE
+"219336_s_at",0.718351269833722,0.194188052458023,1.33887192880388,-5.10237630786445,0.517473012892877,"ASCC1","activating signal cointegrator 1 complex subunit 1",TRUE
+"215684_s_at",0.750020866111355,0.242883563537931,-1.1998161163648,-5.26184339123255,-0.563737095825207,"ASCC2","activating signal cointegrator 1 complex subunit 2",TRUE
+"231269_at",0.597654932724127,0.0737812882779438,1.8767722409033,-4.35588096323633,0.818100829381049,"ASCC3","activating signal cointegrator 1 complex subunit 3",TRUE
+"212815_at",0.782452900355118,0.304621594664679,1.05092312917925,-5.41560895574969,0.416731754693423,"ASCC3","activating signal cointegrator 1 complex subunit 3",TRUE
+"209985_s_at",0.762729892034689,0.262333341364309,-1.15017903804251,-5.31509843726364,-1.00503546981426,"ASCL1","achaete-scute family bHLH transcription factor 1",TRUE
+"209988_s_at",0.841550580403629,0.432921195041913,-0.798738169604559,-5.63363311169332,-1.05842205229423,"ASCL1","achaete-scute family bHLH transcription factor 1",TRUE
+"213768_s_at",0.963115195139351,0.832268927750323,-0.214305403784868,-5.91733895113875,-0.164949941128083,"ASCL1","achaete-scute family bHLH transcription factor 1",TRUE
+"209987_s_at",0.987446510507966,0.940850955005258,0.0750467874396387,-5.93694070357002,0.0972202831100555,"ASCL1","achaete-scute family bHLH transcription factor 1",TRUE
+"229215_at",0.774230543658252,0.288261192075828,-1.08806423876152,-5.37894316750186,-1.53641306967607,"ASCL2","achaete-scute family bHLH transcription factor 2",TRUE
+"207607_at",0.823074246722209,0.389290589796972,-0.878141234704024,-5.57091492709469,-0.942705789259259,"ASCL2","achaete-scute family bHLH transcription factor 2",TRUE
+"221161_at",0.779891498182129,0.301272763294097,1.05840754232789,-5.40831209934629,0.714455902910672,"ASCL3","achaete-scute family bHLH transcription factor 3",TRUE
+"231712_at",0.91269009113888,0.633733271513424,-0.483144110382769,-5.82662430875017,-0.258884545479915,"ASCL5","achaete-scute family bHLH transcription factor 5",TRUE
+"203428_s_at",0.803871276184617,0.34241167171584,0.970216095532532,-5.49131567319791,0.373821358787334,"ASF1A","anti-silencing function 1A histone chaperone",TRUE
+"203427_at",0.853004496782456,0.459335315853115,0.753070065755488,-5.66717459192954,0.293922492410102,"ASF1A","anti-silencing function 1A histone chaperone",TRUE
+"218115_at",0.890405697398587,0.55896767279963,0.593332052868619,-5.76965579903505,0.236704697108394,"ASF1B","anti-silencing function 1B histone chaperone",TRUE
+"206743_s_at",0.868397087637799,0.503218729914009,0.680530395652512,-5.71659691264052,0.461895839960087,"ASGR1","asialoglycoprotein receptor 1",TRUE
+"206130_s_at",0.645250113092125,0.116457761609384,1.6336750647474,-4.71718614724301,0.587425018462545,"ASGR2","asialoglycoprotein receptor 2",TRUE
+"226447_at",0.821137675198948,0.382094196002076,-0.891778898717449,-5.55958698929374,-0.308689807103624,"ASH1L","ASH1 like histone lysine methyltransferase",TRUE
+"218554_s_at",0.931272805346096,0.695359927496691,0.39673278918553,-5.86331067012982,0.106139493471364,"ASH1L","ASH1 like histone lysine methyltransferase",TRUE
+"222667_s_at",0.95952608973576,0.817156718054777,-0.233969852805214,-5.91305584036528,-0.0945570436340439,"ASH1L","ASH1 like histone lysine methyltransferase",TRUE
+"1554057_at",0.623503825356688,0.0943130298332714,-1.7479800883883,-4.55190164458629,-0.591474717304681,"ASH1L-AS1","ASH1L antisense RNA 1",TRUE
+"209517_s_at",0.768852835478002,0.272828087022893,-1.12451960485165,-5.34185260433015,-0.634617311065021,"ASH2L","ASH2 like histone lysine methyltransferase complex subunit",TRUE
+"205156_s_at",0.78187900363728,0.303464600281947,-1.05350229410888,-5.41309967313895,-0.818277622323081,"ASIC1","acid sensing ion channel subunit 1",TRUE
+"37953_s_at",0.896599256925387,0.581358632107026,0.559610805394799,-5.78829310769057,0.225965051734546,"ASIC1","acid sensing ion channel subunit 1",TRUE
+"206690_at",0.740610299769501,0.230193179803225,-1.23383365955555,-5.22421809234314,-1.15124889099188,"ASIC2","acid sensing ion channel subunit 2",TRUE
+"221226_s_at",0.95018792835023,0.773680926980708,0.29110204097464,-5.89849363174747,0.141995651290713,"ASIC4","acid sensing ion channel subunit family member 4",TRUE
+"1564504_at",0.769258076576208,0.275804722603558,1.11737372214021,-5.34920840262901,0.853692701917578,"ASIC5","acid sensing ion channel subunit family member 5",TRUE
+"214498_at",0.980676048578047,0.909547948191172,-0.114914494358376,-5.93325369208431,-0.0810551235010859,"ASIP","agouti signaling protein",TRUE
+"204608_at",0.585850686899876,0.065844581088244,-1.935099170605,-4.26387088701415,-0.55948966440674,"ASL","argininosuccinate lyase",TRUE
+"206779_s_at",0.838363753586919,0.42342161301416,0.815580031131165,-5.62079472676563,0.547993483236951,"ASMT","acetylserotonin O-methyltransferase",TRUE
+"210551_s_at",0.922168942129244,0.667659193633159,-0.435155116454476,-5.8478717174262,-0.392321435036834,"ASMT","acetylserotonin O-methyltransferase",TRUE
+"36554_at",0.582628933729382,0.0643955490905652,-1.94640986863429,-4.24580313703242,-1.1791339480926,"ASMTL","acetylserotonin O-methyltransferase-like",TRUE
+"36553_at",0.617775129514679,0.0888473458934827,-1.77969478019238,-4.50457076392771,-0.952481402102311,"ASMTL","acetylserotonin O-methyltransferase-like",TRUE
+"209394_at",0.6708432030569,0.136572763371801,-1.54474195887535,-4.83981622047114,-0.844768944651131,"ASMTL","acetylserotonin O-methyltransferase-like",TRUE
+"241354_at",0.636860247875294,0.107989599598571,1.67501322402245,-4.65838653991211,0.907213298151188,"ASMTL-AS1","ASMTL antisense RNA 1",TRUE
+"244875_at",0.652051909579505,0.121203540138208,-1.611601365052,-4.74812133726707,-0.961857575628858,"ASMTL-AS1","ASMTL antisense RNA 1",TRUE
+"1552872_at",0.698371741068394,0.169231407360131,1.42102502337922,-5.00127967399338,0.770006485355936,"ASMTL-AS1","ASMTL antisense RNA 1",TRUE
+"207288_at",0.932018790587499,0.699285500382107,-0.391337982315074,-5.86536602497656,-0.168555010111306,"ASMTL-AS1","ASMTL antisense RNA 1",TRUE
+"1552873_s_at",0.963737076458538,0.834427554945698,0.211503759753351,-5.91791873382642,0.0941070508020747,"ASMTL-AS1","ASMTL antisense RNA 1",TRUE
+"202024_at",0.919315730071839,0.656128837015842,0.451343255604488,-5.84094761940359,0.157409586241908,"ASNA1","arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)",TRUE
+"205047_s_at",0.901781358899845,0.599094762692821,-0.533359538443464,-5.80206926974308,-0.233595967058513,"ASNS","asparagine synthetase (glutamine-hydrolyzing)",TRUE
+"241082_at",0.979588787486838,0.901962596442083,0.124601505652637,-5.9321243929947,0.110344744940707,"ASNS","asparagine synthetase (glutamine-hydrolyzing)",TRUE
+"217987_at",0.852380677459291,0.458152567235305,-0.755080417213197,-5.665737315583,-0.247333296196171,"ASNSD1","asparagine synthetase domain containing 1",TRUE
+"228807_at",0.754211951261383,0.247500152346259,1.18777308855336,-5.27494466800306,0.317868674256365,"ASPA","aspartoacylase",TRUE
+"206030_at",0.774230543658252,0.286077810236694,1.09313444171468,-5.37384967809495,0.928456568592906,"ASPA","aspartoacylase",TRUE
+"230912_at",0.778397054392363,0.298313389804516,-1.06507098284007,-5.40177657210482,-0.563143291366908,"ASPDH","aspartate dehydrogenase domain containing",TRUE
+"1557225_at",0.88020017258149,0.535574417673582,-0.629321137607523,-5.74860390118913,-0.3345285138045,"ASPG","asparaginase",TRUE
+"1557226_a_at",0.886374687477145,0.549203754689771,-0.60825458034246,-5.76107192765089,-0.328984032464981,"ASPG","asparaginase",TRUE
+"230429_at",0.682825347106105,0.150786068002322,1.48822868004768,-4.91491816434976,0.983853809766234,"ASPH","aspartate beta-hydroxylase",TRUE
+"229879_at",0.699161781955613,0.170608269741692,1.41624949693678,-5.00729249655539,0.860633797059575,"ASPH","aspartate beta-hydroxylase",TRUE
+"210896_s_at",0.778580821633075,0.298892651434272,1.06376299699733,-5.40306234875407,0.731565119339946,"ASPH","aspartate beta-hydroxylase",TRUE
+"224996_at",0.805746717966166,0.345593473550363,0.963707670498197,-5.49718118525584,0.624678927845242,"ASPH","aspartate beta-hydroxylase",TRUE
+"225008_at",0.816800680706682,0.368814674411196,0.917394304672628,-5.53787371865573,0.56572599104153,"ASPH","aspartate beta-hydroxylase",TRUE
+"205808_at",0.850450293594674,0.453075741231379,0.76374523568232,-5.65950103624122,0.493854587599789,"ASPH","aspartate beta-hydroxylase",TRUE
+"207284_s_at",0.896428361916712,0.580645579114598,-0.56067442888339,-5.78772139569139,-0.506925222625885,"ASPH","aspartate beta-hydroxylase",TRUE
+"209135_at",0.9196456342561,0.658478048282721,0.448035251489595,-5.84238270830259,0.328640117593837,"ASPH","aspartate beta-hydroxylase",TRUE
+"242037_at",0.997608949249317,0.988029520261656,-0.0151735598947563,-5.93957134145635,-0.0148169587263887,"ASPH","aspartate beta-hydroxylase",TRUE
+"214993_at",0.620223198657182,0.0901668111972586,-1.77188821091502,-4.51627920071468,-1.4577920635201,"ASPHD1","aspartate beta-hydroxylase domain containing 1",TRUE
+"1553997_a_at",0.725168361556674,0.203511214487065,-1.31031443918519,-5.13633781885892,-0.729119149966159,"ASPHD1","aspartate beta-hydroxylase domain containing 1",TRUE
+"227014_at",0.813442508625161,0.363819860541291,-0.927187193683067,-5.52942285051884,-0.46391173344426,"ASPHD2","aspartate beta-hydroxylase domain containing 2",TRUE
+"227015_at",0.973071267819624,0.869828990008387,-0.165785770156973,-5.92630544857758,-0.0982359365243415,"ASPHD2","aspartate beta-hydroxylase domain containing 2",TRUE
+"239002_at",0.597654932724127,0.0749888044841382,1.86838490984992,-4.36894952768025,0.676713697000929,"ASPM","abnormal spindle microtubule assembly",TRUE
+"219918_s_at",0.939481320547208,0.728948297407507,0.350939927001912,-5.87987473771567,0.132192373593099,"ASPM","abnormal spindle microtubule assembly",TRUE
+"232238_at",0.94943075115007,0.771325345300963,0.294224220186313,-5.89760718759441,0.116356998453101,"ASPM","abnormal spindle microtubule assembly",TRUE
+"219087_at",0.729083413548563,0.210818111282365,-1.28863661793074,-5.16170404010778,-0.975216913804674,"ASPN","asporin",TRUE
+"224396_s_at",0.825047202440591,0.392425399769002,0.872251883152334,-5.57575675454546,0.637735525711756,"ASPN","asporin",TRUE
+"235514_at",0.840268837320073,0.429373174599918,0.805001333633466,-5.62888814289338,0.240573091836526,"ASPRV1","aspartic peptidase, retroviral-like 1",TRUE
+"218908_at",0.604705077479354,0.0787803249544662,-1.84279342320034,-4.40856782980534,-0.737235345891463,"ASPSCR1","ASPSCR1, UBX domain containing tether for SLC2A4",TRUE
+"222764_at",0.985498770484702,0.930111951926426,-0.0887066761190976,-5.93585156879062,-0.110618645745943,"ASRGL1","asparaginase like 1",TRUE
+"218857_s_at",0.996261754016157,0.981339417779039,-0.0236551675884035,-5.93941093999218,-0.0225143310668159,"ASRGL1","asparaginase like 1",TRUE
+"207076_s_at",0.863835356219448,0.489722030661808,-0.702435772080073,-5.70217455054776,-0.767761316123398,"ASS1","argininosuccinate synthase 1",TRUE
+"221135_s_at",0.465776708318531,0.024112681754495,-2.42097945687757,-3.42846734488645,-0.813333360580343,"ASTE1","asteroid homolog 1 (Drosophila)",TRUE
+"213197_at",0.654038356341937,0.123198939777557,1.60253572174418,-4.76073202885929,1.3288040482187,"ASTN1","astrotactin 1",TRUE
+"209693_at",0.322131160460075,0.00725877206253495,-2.95640126073136,-2.39587875930877,-1.94074290721456,"ASTN2","astrotactin 2",TRUE
+"215407_s_at",0.433660982257499,0.0195909397391466,-2.51637506635608,-3.25185914419331,-1.87498896549057,"ASTN2","astrotactin 2",TRUE
+"1554816_at",0.806674083302402,0.347854684261925,0.959107108909677,-5.50130552841434,0.831078958506857,"ASTN2","astrotactin 2",TRUE
+"221652_s_at",0.812302873476553,0.359531748165295,0.935666448422282,-5.52203892818875,0.373887373845605,"ASUN","asunder, spermatogenesis regulator",TRUE
+"212237_at",0.535697382361465,0.0429793924381206,2.14712380184276,-3.91362701252828,0.891176964295564,"ASXL1","additional sex combs like 1, transcriptional regulator",TRUE
+"212238_at",0.61760967235709,0.0877486695055023,1.78627158278678,-4.49467757829373,0.588105637656557,"ASXL1","additional sex combs like 1, transcriptional regulator",TRUE
+"212234_at",0.686108994812404,0.154455586686577,1.47434853042435,-4.93302014316699,0.655881990907687,"ASXL1","additional sex combs like 1, transcriptional regulator",TRUE
+"244519_at",0.699391325858549,0.170817693142234,1.41552583690254,-5.00820219957724,0.773943123784903,"ASXL1","additional sex combs like 1, transcriptional regulator",TRUE
+"242438_at",0.71454754703986,0.189771748174214,1.35277572258566,-5.08561896590452,0.777994380861244,"ASXL1","additional sex combs like 1, transcriptional regulator",TRUE
+"242439_s_at",0.772988605474261,0.28354905671984,1.09904170762243,-5.36788869859608,0.751682808192609,"ASXL1","additional sex combs like 1, transcriptional regulator",TRUE
+"1555266_a_at",0.774230543658252,0.287607839845212,1.08957852674666,-5.37742413422083,0.329267038390679,"ASXL2","additional sex combs like 2, transcriptional regulator",TRUE
+"226251_at",0.834881450121645,0.413514582241838,0.833398040877919,-5.60693899675504,0.369792103655998,"ASXL2","additional sex combs like 2, transcriptional regulator",TRUE
+"237095_at",0.847506138098347,0.446190474351365,0.77559079723604,-5.65086674627151,0.266647318054177,"ASXL2","additional sex combs like 2, transcriptional regulator",TRUE
+"229359_at",0.863318594825537,0.487531797998002,0.706023008048861,-5.6997712080085,0.275680086617407,"ASXL2","additional sex combs like 2, transcriptional regulator",TRUE
+"218659_at",0.872668627020452,0.516227970553762,0.659728087081206,-5.72988833136528,0.212998890247535,"ASXL2","additional sex combs like 2, transcriptional regulator",TRUE
+"240072_at",0.914632961724784,0.640530710382778,0.473439988390002,-5.83109627648687,0.229789007671656,"ASXL2","additional sex combs like 2, transcriptional regulator",TRUE
+"233686_at",0.714054210868775,0.189110429079971,1.35487959566118,-5.08307068450324,0.806252461705455,"ASXL3","additional sex combs like 3, transcriptional regulator",TRUE
+"233536_at",0.84204847460846,0.435269897193432,0.794609564590741,-5.63674188489039,0.333243996814897,"ASXL3","additional sex combs like 3, transcriptional regulator",TRUE
+"232838_at",0.882123307082787,0.539648109287701,-0.622994845670275,-5.7523910170563,-0.36375100948812,"ASXL3","additional sex combs like 3, transcriptional regulator",TRUE
+"214162_at",0.987967825391489,0.942514778210129,-0.0729317988722866,-5.93709310096736,-0.0563895768246492,"ASXL3","additional sex combs like 3, transcriptional regulator",TRUE
+"1569729_a_at",0.945498722604777,0.753906708136726,0.317406808596297,-5.89073207054408,0.295420867084987,"ASZ1","ankyrin repeat, SAM and basic leucine zipper domain containing 1",TRUE
+"224850_at",0.851733415458562,0.456710147413031,-0.757536355782453,-5.66397655188217,-0.239689717276173,"ATAD1","ATPase family, AAA domain containing 1",TRUE
+"227585_at",0.936456142259101,0.716343911656035,0.368029372169086,-5.87392737613221,0.118125666312397,"ATAD1","ATPase family, AAA domain containing 1",TRUE
+"218782_s_at",0.975196332002567,0.879530839616962,0.153323701176689,-5.92824000625207,0.0712512439050386,"ATAD2","ATPase family, AAA domain containing 2",TRUE
+"235266_at",0.985361089461736,0.927530257101018,0.0919930416892702,-5.9355624424228,0.0505080934880482,"ATAD2","ATPase family, AAA domain containing 2",TRUE
+"222740_at",0.990980060324272,0.957592351759427,-0.0537800803574357,-5.93827484768097,-0.0233923549597961,"ATAD2","ATPase family, AAA domain containing 2",TRUE
+"228401_at",0.991689960875868,0.961389295140383,-0.0489606919362329,-5.93851598512535,-0.0203152208207289,"ATAD2","ATPase family, AAA domain containing 2",TRUE
+"213387_at",0.358427723880268,0.0101874141411795,-2.8087413608653,-2.68989343431788,-0.886466418111359,"ATAD2B","ATPase family, AAA domain containing 2B",TRUE
+"232908_at",0.439717285988889,0.0202668049509282,-2.50088917146556,-3.2807733595243,-1.04872731051819,"ATAD2B","ATPase family, AAA domain containing 2B",TRUE
+"1558807_at",0.909748582642183,0.62466906793878,0.496158109126331,-5.82048784058795,0.301402587838955,"ATAD2B","ATPase family, AAA domain containing 2B",TRUE
+"227700_x_at",0.778481681746654,0.298521206026527,1.06460152080959,-5.40223822564431,0.389576516068542,"ATAD3A","ATPase family, AAA domain containing 3A",TRUE
+"227237_x_at",0.76912869907427,0.274759484117698,1.11987653935502,-5.34663678591136,0.445703911507747,"ATAD3B","ATPase family, AAA domain containing 3B",TRUE
+"223617_x_at",0.78638420006208,0.311789728209795,1.0350966718108,-5.43088544700022,0.353578604247589,"ATAD3B","ATPase family, AAA domain containing 3B",TRUE
+"233091_at",0.935344003152574,0.712486640023748,-0.37328134177788,-5.87204355305933,-0.260735173250334,"ATAD3B","ATPase family, AAA domain containing 3B",TRUE
+"1552641_s_at",0.835952408568777,0.41708569330007,0.826944654869397,-5.61198968776593,0.539807848210733,"ATAD3B///ATAD3A","ATPase family, AAA domain containing 3B///ATPase family, AAA domain containing 3A",TRUE
+"219068_x_at",0.888686718625571,0.555073643183599,0.599266960867186,-5.7662665301089,0.214095478154871,"ATAD3B///ATAD3A","ATPase family, AAA domain containing 3B///ATPase family, AAA domain containing 3A",TRUE
+"240210_at",0.861659105448003,0.48302958673502,0.713426223442646,-5.69477440352439,0.59054005801207,"ATAD3C","ATPase family, AAA domain containing 3C",TRUE
+"220223_at",0.88767000285873,0.552319579061673,0.603477575063208,-5.76384220279962,0.172367388392995,"ATAD5","ATPase family, AAA domain containing 5",TRUE
+"228510_at",0.864111333851332,0.491287993766217,0.699876642086971,-5.70388195849042,0.488437789888342,"ATAT1","alpha tubulin acetyltransferase 1",TRUE
+"218874_s_at",0.988948717228281,0.946581681713741,-0.0677635207969087,-5.93744718558387,-0.0278141879359346,"ATAT1","alpha tubulin acetyltransferase 1",TRUE
+"227365_at",0.898813992560978,0.588767149721224,-0.548598123532401,-5.79415062942976,-0.272107136430043,"ATCAY","ATCAY, caytaxin",TRUE
+"225497_at",0.797490281058829,0.330857463431901,0.994205009198688,-5.46938584567083,0.364404787060659,"ATE1","arginyltransferase 1",TRUE
+"234874_at",0.864894115958506,0.492976240551954,-0.69712291308079,-5.70571256026721,-0.34787052360331,"ATE1","arginyltransferase 1",TRUE
+"238857_at",0.904832003218088,0.6095903191045,0.518002974427959,-5.80982959131428,0.252231840787221,"ATE1","arginyltransferase 1",TRUE
+"234584_s_at",0.925091998149497,0.675718119528547,0.423910731611472,-5.85253508627767,0.149980473193152,"ATE1","arginyltransferase 1",TRUE
+"1565269_s_at",0.755639383619058,0.249804102420575,-1.1818257287625,-5.28137214369654,-0.444975053735776,"ATF1","activating transcription factor 1",TRUE
+"1558233_s_at",0.867972140419125,0.501409822184364,-0.683446732329063,-5.71470200156813,-0.223297735751926,"ATF1","activating transcription factor 1",TRUE
+"222103_at",0.908801761853008,0.621282122201178,-0.50104320051115,-5.81814326616091,-0.167821454367726,"ATF1","activating transcription factor 1",TRUE
+"212984_at",0.6708432030569,0.136496956005456,-1.54505607816761,-4.83939256428973,-0.565848596794465,"ATF2","activating transcription factor 2",TRUE
+"205446_s_at",0.899995753396531,0.59412065344931,-0.540682758083866,-5.79829086675703,-0.168963734865537,"ATF2","activating transcription factor 2",TRUE
+"1555146_at",0.951339758531576,0.77747916057688,0.286073915927905,-5.89990149077179,0.281956151354036,"ATF2","activating transcription factor 2",TRUE
+"1554980_a_at",0.76150249762201,0.260602489669359,1.15448321100671,-5.3105586016753,0.487326180801558,"ATF3","activating transcription factor 3",TRUE
+"1554420_at",0.776983560547865,0.296083135185004,1.07012394965545,-5.39679611576279,0.507437642914586,"ATF3","activating transcription factor 3",TRUE
+"202672_s_at",0.897011777275924,0.582700819268568,0.557610502878135,-5.78936544411764,0.348732510957412,"ATF3","activating transcription factor 3",TRUE
+"200779_at",0.99186228645105,0.96233043380472,0.0477663107269628,-5.93857224865597,0.0141417204867338,"ATF4","activating transcription factor 4",TRUE
+"204998_s_at",0.485183483700012,0.0279427050472479,-2.3523740487852,-3.55316762912184,-0.975790410823263,"ATF5","activating transcription factor 5",TRUE
+"204999_s_at",0.805335305758344,0.344647667469774,-0.965638046770183,-5.49544525640482,-0.515029298733232,"ATF5","activating transcription factor 5",TRUE
+"230938_x_at",0.851319596585235,0.455118814344265,-0.760251253778446,-5.6620238357038,-0.418286684708604,"ATF5","activating transcription factor 5",TRUE
+"217389_s_at",0.871744769522775,0.514173800717236,0.662993170659167,-5.72782829032522,0.414177202106978,"ATF5","activating transcription factor 5",TRUE
+"203952_at",0.627092759817312,0.0985995370253432,-1.72419146802161,-4.58699043620859,-0.82922901603976,"ATF6","activating transcription factor 6",TRUE
+"217550_at",0.809930331505913,0.353341146472322,0.948028365647285,-5.51116334101032,0.452256057448658,"ATF6","activating transcription factor 6",TRUE
+"231927_at",0.965992617204023,0.840805552985599,-0.20323588438216,-5.9195854246453,-0.0702761357845141,"ATF6","activating transcription factor 6",TRUE
+"226941_at",0.998870448604467,0.995313028179134,0.0059409175202201,-5.93966629011359,0.00247964958880686,"ATF6","activating transcription factor 6",TRUE
+"203168_at",0.724568343940805,0.201716777363325,1.31573038820775,-5.12994445070878,0.468150358129517,"ATF6B","activating transcription factor 6 beta",TRUE
+"1554487_a_at",0.772153322615079,0.282513428408713,1.10147197898258,-5.36542803476515,0.703431113114201,"ATF6B","activating transcription factor 6 beta",TRUE
+"216208_s_at",0.864894115958506,0.493485053718972,0.696294039028524,-5.70626222432396,0.406808857264919,"ATF6B","activating transcription factor 6 beta",TRUE
+"228829_at",0.358427723880268,0.00983461663773299,-2.8242044610191,-2.65939522065148,-1.39035968932567,"ATF7","activating transcription factor 7",TRUE
+"228830_s_at",0.384135218769668,0.012314064870923,-2.72508622143373,-2.8536184932892,-1.10154710451045,"ATF7","activating transcription factor 7",TRUE
+"244587_at",0.760486759210509,0.2595955604525,-1.15699691008237,-5.30790038294587,-0.323439193745568,"ATF7","activating transcription factor 7",TRUE
+"235160_at",0.863993702749895,0.490631485742638,0.700948949912652,-5.70316725630971,0.446848919926623,"ATF7","activating transcription factor 7",TRUE
+"206684_s_at",0.944894573324841,0.752200023849359,-0.319687613437153,-5.89002777062591,-0.0932342840157236,"ATF7","activating transcription factor 7",TRUE
+"218987_at",0.677013732819214,0.14400986581714,1.51460053027671,-4.88014992813535,0.474867597862939,"ATF7IP","activating transcription factor 7 interacting protein",TRUE
+"207728_at",0.710372201621696,0.183109530923764,1.37424070402261,-5.05946485447841,0.490297536735546,"ATF7IP","activating transcription factor 7 interacting protein",TRUE
+"225917_at",0.766989207029679,0.268077746277591,1.13604260371902,-5.3299038370758,0.422170270552295,"ATF7IP","activating transcription factor 7 interacting protein",TRUE
+"231825_x_at",0.801892820429336,0.339508612703776,0.976190503344259,-5.4858997141132,0.291823430917161,"ATF7IP","activating transcription factor 7 interacting protein",TRUE
+"228381_at",0.974424905435949,0.874780342578793,-0.159422504592408,-5.9273120870632,-0.10685677562032,"ATF7IP2","activating transcription factor 7 interacting protein 2",TRUE
+"219870_at",0.996261754016157,0.981616247817482,0.0233041758942646,-5.93941896771874,0.0151868740100518,"ATF7IP2","activating transcription factor 7 interacting protein 2",TRUE
+"1570523_s_at",0.803903145379763,0.342474854061079,0.970086454132345,-5.4914328602582,0.386020341340407,"ATG10","autophagy related 10",TRUE
+"223677_at",0.893859847265625,0.569372479667951,0.577578159130021,-5.77849417287488,0.231188865487899,"ATG10","autophagy related 10",TRUE
+"207774_at",0.937462538530338,0.722881520888021,0.359151852496578,-5.87705172579269,0.220818956715929,"ATG10","autophagy related 10",TRUE
+"243477_at",0.942961933269639,0.744155852672153,-0.330461367820055,-5.8866334134712,-0.284233880788626,"ATG10","autophagy related 10",TRUE
+"218214_at",0.51531387545335,0.0358445689781113,-2.23461022457588,-3.76239573744677,-0.874254910217156,"ATG101","autophagy related 101",TRUE
+"213930_at",0.39149295959037,0.0132631527564393,-2.69209459546845,-2.9175746225638,-0.825504939112752,"ATG12","autophagy related 12",TRUE
+"213026_at",0.68033297785336,0.147535710964376,-1.50075500147809,-4.89846470033623,-0.47786942549304,"ATG12","autophagy related 12",TRUE
+"204833_at",0.961899417580562,0.826908276592982,0.221270544760856,-5.91586464750463,0.099938330153627,"ATG12","autophagy related 12",TRUE
+"203364_s_at",0.689985677226298,0.159405645590037,-1.45604262087282,-4.95668412181865,-0.455406594014724,"ATG13","autophagy related 13",TRUE
+"209021_x_at",0.760439386481756,0.25935773650201,-1.15759166686455,-5.3072706893449,-0.387400104000751,"ATG13","autophagy related 13",TRUE
+"203363_s_at",0.796838451167002,0.329652388661489,-0.996740054248206,-5.4670399401577,-0.250051420939565,"ATG13","autophagy related 13",TRUE
+"204568_at",0.819018525257656,0.373682050167765,-0.907935753590163,-5.54595752106651,-0.251407694023754,"ATG14","autophagy related 14",TRUE
+"232612_s_at",0.723655063748891,0.20062028620173,-1.31905830622031,-5.12600489560945,-0.387896729844343,"ATG16L1","autophagy related 16 like 1",TRUE
+"220521_s_at",0.819723837900625,0.377095830485671,0.901350453139076,-5.551540006594,0.548980765334617,"ATG16L1","autophagy related 16 like 1",TRUE
+"229389_at",0.870113177780394,0.50834548472326,0.672296966980318,-5.72190480828257,0.506962633620481,"ATG16L2","autophagy related 16 like 2",TRUE
+"225883_at",0.978257169730337,0.895084073954798,-0.13339639265237,-5.93102010316421,-0.0833710933493137,"ATG16L2","autophagy related 16 like 2",TRUE
+"213300_at",0.789503009592599,0.316378872099157,-1.02509861131631,-5.44042838891179,-0.371710512551314,"ATG2A","autophagy related 2A",TRUE
+"219164_s_at",0.397229407433966,0.0137565266607771,-2.67581535091205,-2.94899999688213,-0.992543481796915,"ATG2B","autophagy related 2B",TRUE
+"226684_at",0.596382916302699,0.0729367414455123,-1.88270995440471,-4.34660430690128,-0.656109913898494,"ATG2B","autophagy related 2B",TRUE
+"222840_at",0.871744769522775,0.51426084626914,-0.6628546657533,-5.72791587529534,-0.285860160908332,"ATG2B","autophagy related 2B",TRUE
+"1559485_at",0.957571530817866,0.809219627107088,-0.244335229066283,-5.91064771553433,-0.0953441978997098,"ATG2B","autophagy related 2B",TRUE
+"221492_s_at",0.46584896273628,0.0241692671566778,-2.41989460978277,-3.43045461428808,-0.640064367079701,"ATG3","autophagy related 3",TRUE
+"220237_at",0.858826390511142,0.474715680142499,-0.727203398044493,-5.68534349232882,-0.323966636024736,"ATG3","autophagy related 3",TRUE
+"213115_at",0.636147339487472,0.107504648683144,-1.67746238964188,-4.65486776515228,-0.617642658836637,"ATG4A","autophagy related 4A cysteine peptidase",TRUE
+"212280_x_at",0.462669793287247,0.0234152761800398,-2.43454724758864,-3.40357231661622,-0.804648089871202,"ATG4B","autophagy related 4B cysteine peptidase",TRUE
+"204903_x_at",0.605074025447346,0.0789468399776889,-1.84169426946318,-4.41026072294742,-0.505065528711434,"ATG4B","autophagy related 4B cysteine peptidase",TRUE
+"204902_s_at",0.829626140494984,0.401088390886217,-0.856133388700525,-5.58885334899429,-0.303902013982684,"ATG4B","autophagy related 4B cysteine peptidase",TRUE
+"228190_at",0.941947927515757,0.739179474890818,-0.337146297807578,-5.88447131094426,-0.15618479610683,"ATG4C","autophagy related 4C cysteine peptidase",TRUE
+"226871_s_at",0.898813992560978,0.588720702102652,-0.548666952753468,-5.79411437100785,-0.152118364564148,"ATG4D","autophagy related 4D cysteine peptidase",TRUE
+"210639_s_at",0.60112407301868,0.0768185440911114,1.85589747737406,-4.38832985064585,0.636037551576102,"ATG5","autophagy related 5",TRUE
+"202511_s_at",0.615005518451136,0.0856525238354889,1.79901876538532,-4.47542695317852,0.657659405688159,"ATG5","autophagy related 5",TRUE
+"202512_s_at",0.923124080520773,0.670562860334292,0.431097216929443,-5.84956847386785,0.222980434690459,"ATG5","autophagy related 5",TRUE
+"1569827_at",0.74982446674784,0.24267295727669,-1.20036959524715,-5.26123851389673,-1.04347153478467,"ATG7","autophagy related 7",TRUE
+"218673_s_at",0.865345395265289,0.494723850828493,-0.694278038380931,-5.70759652121008,-0.188491647317866,"ATG7","autophagy related 7",TRUE
+"222709_at",0.89037721023972,0.558894116160041,-0.593443961217199,-5.76959219268844,-0.16276831298958,"ATG7","autophagy related 7",TRUE
+"224025_s_at",0.989638901366417,0.94982592191568,-0.0636420574961605,-5.93771091589739,-0.0178915752969608,"ATG7","autophagy related 7",TRUE
+"202492_at",0.617775129514679,0.0884780013120889,-1.78189786439536,-4.50125973107516,-0.547215193806554,"ATG9A","autophagy related 9A",TRUE
+"1553390_at",0.857436624285661,0.472983487144888,-0.730091593456088,-5.68334469450987,-0.616389625835551,"ATG9B","autophagy related 9B",TRUE
+"229252_at",0.987952662687141,0.942363187278642,-0.0731244812176852,-5.93707939733206,-0.0327725590928916,"ATG9B","autophagy related 9B",TRUE
+"208758_at",0.700061364939874,0.171557590392807,-1.41297480323022,-5.01140601977753,-0.554648364861775,"ATIC","5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase",TRUE
+"223340_at",0.99901091854407,0.99678175837832,-0.00407923210117557,-5.93967537595634,-0.0044332357996959,"ATL1","atlastin GTPase 1",TRUE
+"222700_at",0.406049718268978,0.0152951961991627,2.62836347559945,-3.04008589275017,0.909482993295766,"ATL2","atlastin GTPase 2",TRUE
+"1553603_s_at",0.581367983493308,0.0638145803001428,1.9510078414576,-4.23843769051321,0.751855429185445,"ATL2","atlastin GTPase 2",TRUE
+"237968_at",0.719965577309824,0.195772720082085,1.33394344094861,-5.10828142234603,0.560714434704246,"ATL2","atlastin GTPase 2",TRUE
+"224893_at",0.55074985379986,0.0491232923937775,-2.08174488871149,-4.02416048923562,-0.761600656664054,"ATL3","atlastin GTPase 3",TRUE
+"223453_s_at",0.908375053779996,0.619246779713931,-0.503984782222965,-5.81672065407364,-0.382786222819099,"ATL3","atlastin GTPase 3",TRUE
+"223452_s_at",0.984244246588495,0.923336473817563,-0.0973337435127141,-5.93507016722647,-0.0433362943090465,"ATL3","atlastin GTPase 3",TRUE
+"1553387_at",0.660446284140125,0.128380852452515,1.57955204271315,-4.79245501536242,0.815944892503202,"ATM","ATM serine/threonine kinase",TRUE
+"1554631_at",0.753294178355034,0.246519986197924,1.19031582504133,-5.27218807971164,0.475322322238181,"ATM","ATM serine/threonine kinase",TRUE
+"212672_at",0.769258076576208,0.276558042713965,1.11557418687753,-5.35105425557571,0.615252605988216,"ATM","ATM serine/threonine kinase",TRUE
+"208442_s_at",0.801587742916188,0.338719886415051,0.977819719698624,-5.48441752540841,0.487975889281612,"ATM","ATM serine/threonine kinase",TRUE
+"210858_x_at",0.889389445320988,0.557142924074584,0.596110471119903,-5.76807317564383,0.30518725339058,"ATM","ATM serine/threonine kinase",TRUE
+"1570352_at",0.901781358899845,0.599029645177193,0.533455217568105,-5.80202022738857,0.293392583861036,"ATM","ATM serine/threonine kinase",TRUE
+"201855_s_at",0.750594407352788,0.243568107594466,-1.1980196030681,-5.26380506542594,-0.615517445959858,"ATMIN","ATM interactor",TRUE
+"238777_x_at",0.940668681806864,0.734432609801382,0.343537543881974,-5.88236415204604,0.106992698138519,"ATMIN","ATM interactor",TRUE
+"201854_s_at",0.95168059103032,0.778482596453399,0.284746823363513,-5.90026901332588,0.0970583110319545,"ATMIN","ATM interactor",TRUE
+"211076_x_at",0.769687659596967,0.277116787767815,-1.11424175915907,-5.35241927965513,-0.576635874035911,"ATN1","atrophin 1",TRUE
+"1555754_s_at",0.959649219607517,0.817895969956961,-0.233005783645951,-5.9132745398742,-0.116748439888855,"ATN1","atrophin 1",TRUE
+"208871_at",0.973615804712521,0.872995378985714,-0.161715672374329,-5.92695384745693,-0.109881844113781,"ATN1","atrophin 1",TRUE
+"40489_at",0.996261754016157,0.981648960301868,0.0232627000657728,-5.93941990840778,0.00849527347230072,"ATN1","atrophin 1",TRUE
+"221336_at",0.986342822130003,0.935494341134307,0.0818583437009623,-5.93642030069385,0.0704067062252722,"ATOH1","atonal bHLH transcription factor 1",TRUE
+"1552878_at",0.740039310225527,0.228433195244306,1.238662850862,-5.21880311746409,0.817321717149463,"ATOH7","atonal bHLH transcription factor 7",TRUE
+"1552879_a_at",0.915742010892393,0.644574915242757,0.467688293470825,-5.83370492925843,0.297812552847022,"ATOH7","atonal bHLH transcription factor 7",TRUE
+"1558705_at",0.560295667354693,0.0542823255597222,2.03228815779864,-4.1063033999813,0.596239577623377,"ATOH8","atonal bHLH transcription factor 8",TRUE
+"228890_at",0.858994261239434,0.47539958998603,0.726064775859283,-5.68612941577928,0.302868894716224,"ATOH8","atonal bHLH transcription factor 8",TRUE
+"1558706_a_at",0.934048461921637,0.707969864227513,0.37944491107331,-5.86979916372676,0.161679592978513,"ATOH8","atonal bHLH transcription factor 8",TRUE
+"203454_s_at",0.620130575154958,0.0898789222022589,-1.77358307369454,-4.51374041598782,-0.758909877048664,"ATOX1","antioxidant 1 copper chaperone",TRUE
+"214256_at",0.899808883319249,0.593091370966942,0.542201866457082,-5.79750081153979,0.198805974503869,"ATP10A","ATPase phospholipid transporting 10A (putative)",TRUE
+"214255_at",0.965992617204023,0.8407307283851,-0.203332795295806,-5.91956627205183,-0.134255222549,"ATP10A","ATPase phospholipid transporting 10A (putative)",TRUE
+"1568743_at",0.983212176432519,0.918253707788754,-0.103810452859249,-5.93443595403934,-0.0665086397595092,"ATP10A","ATPase phospholipid transporting 10A (putative)",TRUE
+"220920_at",0.708894565317004,0.180873770757043,1.38158253420394,-5.05044055658971,1.0343342193469,"ATP10B","ATPase phospholipid transporting 10B (putative)",TRUE
+"214070_s_at",0.8111749793648,0.355202970971183,-0.944295272839619,-5.51446138846011,-0.319534498652989,"ATP10B","ATPase phospholipid transporting 10B (putative)",TRUE
+"213238_at",0.542397752248982,0.045556547265042,2.1187365914735,-3.96188737311638,2.16785680556101,"ATP10D","ATPase phospholipid transporting 10D (putative)",TRUE
+"241603_at",0.344817137069397,0.00871183538890376,2.87719173503374,-2.55435732274325,1.99381617303733,"ATP11A","ATPase phospholipid transporting 11A",TRUE
+"213582_at",0.535243600695458,0.0427700747006677,2.14949633333626,-3.90957522233573,1.95130101067262,"ATP11A","ATPase phospholipid transporting 11A",TRUE
+"216488_s_at",0.580630437263151,0.0633753034587674,1.95450900452431,-4.23282124530996,1.84484643217966,"ATP11A","ATPase phospholipid transporting 11A",TRUE
+"215842_s_at",0.637485146909712,0.108983688412959,1.67002167757824,-4.66554593948475,1.46452843858811,"ATP11A","ATPase phospholipid transporting 11A",TRUE
+"230875_s_at",0.64484773720849,0.115280880013283,1.63926554645106,-4.70929996944419,1.80395413728927,"ATP11A","ATPase phospholipid transporting 11A",TRUE
+"241604_at",0.916373975873706,0.646883767221245,0.464411807206347,-5.83517700554195,0.230230742518364,"ATP11A","ATPase phospholipid transporting 11A",TRUE
+"1556855_a_at",0.755685495730197,0.249896654612782,-1.18158767454342,-5.28162882945866,-0.673139901718071,"ATP11A-AS1","ATP11A antisense RNA 1",TRUE
+"1556854_at",0.765934384067577,0.266179376232016,1.14068943094904,-5.32505490655324,0.707682854704034,"ATP11A-AS1","ATP11A antisense RNA 1",TRUE
+"1561699_a_at",0.942373096422033,0.741163607993177,-0.334479086333743,-5.88533910131967,-0.26313320050517,"ATP11A-AS1","ATP11A antisense RNA 1",TRUE
+"238811_at",0.362885168249175,0.0104979221874925,2.79554734380107,-2.71585962189522,1.60074463042001,"ATP11B","ATPase phospholipid transporting 11B (putative)",TRUE
+"1564064_a_at",0.468732760220321,0.0247211440757715,2.40943566512063,-3.44958872255079,1.60289190139106,"ATP11B","ATPase phospholipid transporting 11B (putative)",TRUE
+"212536_at",0.478045735223536,0.0266217386341799,2.3749972811984,-3.51226775591699,1.80862731742083,"ATP11B","ATPase phospholipid transporting 11B (putative)",TRUE
+"1554557_at",0.571677937624457,0.059442215703669,1.98685032693214,-4.18061722256094,2.06728676280663,"ATP11B","ATPase phospholipid transporting 11B (putative)",TRUE
+"1564063_a_at",0.624331975868069,0.0956532981288152,1.74044442677484,-4.56305551662178,0.97221376848654,"ATP11B","ATPase phospholipid transporting 11B (putative)",TRUE
+"1554556_a_at",0.760463372361683,0.259534505459701,1.1571495596266,-5.30773879365947,1.01211826188097,"ATP11B","ATPase phospholipid transporting 11B (putative)",TRUE
+"242690_at",0.870433264908839,0.508954471078219,0.671322056631475,-5.72252921549257,0.545887286927107,"ATP11C","ATPase phospholipid transporting 11C",TRUE
+"226785_at",0.950887541143339,0.775687270594094,0.288445084538252,-5.8992406029332,0.196558350973088,"ATP11C","ATPase phospholipid transporting 11C",TRUE
+"207367_at",0.739367922105944,0.227321093648596,1.24172894330718,-5.21535565326359,0.721484732857509,"ATP12A","ATPase H+/K+ transporting non-gastric alpha2 subunit",TRUE
+"218052_s_at",0.615821255316333,0.0866545966579832,-1.79289173090978,-4.48469234205091,-0.536241195627053,"ATP13A1","ATPase 13A1",TRUE
+"218608_at",0.869715052099024,0.507345200034587,-0.673899718762922,-5.72087639835352,-0.377437615675005,"ATP13A2","ATPase 13A2",TRUE
+"212297_at",0.362897608186913,0.0105327158784559,2.7940920726396,-2.71872041086832,0.977711140715764,"ATP13A3","ATPase 13A3",TRUE
+"219558_at",0.498703893437511,0.0313400822562058,2.29842074958928,-3.64980383791798,1.12966529221089,"ATP13A3","ATPase 13A3",TRUE
+"1557136_at",0.906777991824897,0.614817310797285,-0.51040213060191,-5.81358889268257,-0.442932177901711,"ATP13A4","ATPase 13A4",TRUE
+"1559571_a_at",0.911065290090707,0.628955818463169,0.489992684416143,-5.82341487789076,0.358576987081198,"ATP13A4","ATPase 13A4",TRUE
+"233535_at",0.919695424525124,0.658608813343255,0.447851266223418,-5.84246222144002,0.269627957936978,"ATP13A4","ATPase 13A4",TRUE
+"231512_at",0.94895689004559,0.768584199240707,-0.297861206505442,-5.89656275583611,-0.186583165017746,"ATP13A4-AS1","ATP13A4 antisense RNA 1",TRUE
+"1561332_at",0.71100904734581,0.184717646739775,1.36900372572804,-5.06587751629315,0.371279332490379,"ATP13A5","ATPase 13A5",TRUE
+"243585_at",0.821187434813103,0.382337201968372,0.891315658776936,-5.5599744265991,0.612258876754027,"ATP13A5","ATPase 13A5",TRUE
+"220948_s_at",0.965947634024688,0.840458360234522,-0.203685576407532,-5.9194964747863,-0.084875479721573,"ATP1A1","ATPase Na+/K+ transporting subunit alpha 1",TRUE
+"244606_at",0.967972396327188,0.848876825955116,0.192793654887167,-5.92159583827259,0.0859523509260525,"ATP1A1","ATPase Na+/K+ transporting subunit alpha 1",TRUE
+"1559376_at",0.716749536957327,0.192769451901201,1.34331076121504,-5.09704223706321,0.679664311030132,"ATP1A1-AS1","ATP1A1 antisense RNA 1",TRUE
+"236623_at",0.988706054965124,0.945349823235963,-0.0693287775673229,-5.9373426929809,-0.0508945247754635,"ATP1A1-AS1","ATP1A1 antisense RNA 1",TRUE
+"203295_s_at",0.711720566366182,0.185197046139765,-1.36744949734133,-5.06777674150147,-0.934597065461561,"ATP1A2","ATPase Na+/K+ transporting subunit alpha 2",TRUE
+"203296_s_at",0.932101785170752,0.700725737098737,-0.389361673600055,-5.86611203508844,-0.335918727792662,"ATP1A2","ATPase Na+/K+ transporting subunit alpha 2",TRUE
+"1558612_a_at",0.748184017928985,0.240513521210043,1.20606559360034,-5.25499948291656,0.715963052681949,"ATP1A4","ATPase Na+/K+ transporting subunit alpha 4",TRUE
+"1565346_a_at",0.966641191718519,0.845026337557259,0.19777242523362,-5.92065046327072,0.111875331829038,"ATP1A4","ATPase Na+/K+ transporting subunit alpha 4",TRUE
+"1564241_at",0.974536463688956,0.875477592841079,0.158526975735254,-5.92745060123522,0.0664573476924373,"ATP1A4","ATPase Na+/K+ transporting subunit alpha 4",TRUE
+"201243_s_at",0.55679801038721,0.0520267538599189,-2.05337027858301,-4.07144599514312,-0.937804590750488,"ATP1B1","ATPase Na+/K+ transporting subunit beta 1",TRUE
+"201242_s_at",0.61760967235709,0.0877366823110592,-1.78634372984394,-4.49456890316852,-1.04223950268946,"ATP1B1","ATPase Na+/K+ transporting subunit beta 1",TRUE
+"204311_at",0.623667408398064,0.0948588147028411,1.74490041672451,-4.55646431389116,0.86933770303231,"ATP1B2","ATPase Na+/K+ transporting subunit beta 2",TRUE
+"226570_at",0.778686132916778,0.299398390899556,1.06262250373984,-5.40418232149879,0.676524181792175,"ATP1B3","ATPase Na+/K+ transporting subunit beta 3",TRUE
+"229709_at",0.804537788156734,0.343332306821483,0.968328693525799,-5.49302034603529,0.825010042557024,"ATP1B3","ATPase Na+/K+ transporting subunit beta 3",TRUE
+"208836_at",0.820536502908875,0.380077728205784,0.895630347352666,-5.55635856120754,0.375992805919383,"ATP1B3","ATPase Na+/K+ transporting subunit beta 3",TRUE
+"243737_at",0.82153774281298,0.383944521086012,0.888256487435642,-5.56252832700707,0.527209187566418,"ATP1B4","ATPase Na+/K+ transporting family member beta 4",TRUE
+"220556_at",0.849189309967511,0.449983760506535,0.769051154753894,-5.65564904087564,0.625803132817012,"ATP1B4","ATPase Na+/K+ transporting family member beta 4",TRUE
+"227678_at",0.57908326705471,0.0620336661205201,-1.96533653154528,-4.21540866601834,-0.983306164504757,"ATP23","ATP23 metallopeptidase and ATP synthase assembly factor homolog",TRUE
+"1554349_at",0.7717895132349,0.281823277984315,1.10309511579758,-5.36378190893901,0.862069214887483,"ATP23","ATP23 metallopeptidase and ATP synthase assembly factor homolog",TRUE
+"205444_at",0.43475103335315,0.0197596034363526,-2.51246441964886,-3.25916958569419,-0.916266003073188,"ATP2A1","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1",TRUE
+"230693_at",0.796327569283512,0.328591397876587,-0.998977314131038,-5.46496509595078,-0.391251032857397,"ATP2A1","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1",TRUE
+"230696_at",0.859619953488811,0.477662675562893,-0.72230385699559,-5.6887170365523,-0.307871259059672,"ATP2A1-AS1","ATP2A1 antisense RNA 1",TRUE
+"212362_at",0.610455440146151,0.0831071134835982,1.81486539359603,-4.45135733825558,0.549586500486885,"ATP2A2","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",TRUE
+"212361_s_at",0.649719797552144,0.120238907906152,1.61602874686106,-4.74194264067068,0.666333514861805,"ATP2A2","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",TRUE
+"239996_x_at",0.86506123498463,0.494180569062824,0.695161811543863,-5.70701204745002,0.428306713190545,"ATP2A2","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",TRUE
+"209186_at",0.975398143273847,0.882219776855673,0.149874230479513,-5.92874884836116,0.0471132004630483,"ATP2A2","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",TRUE
+"213042_s_at",0.647518308302168,0.118739800374735,-1.62296855910875,-4.73223132989687,-2.20403212938853,"ATP2A3","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3",TRUE
+"207521_s_at",0.840316532545213,0.4294490087312,-0.80486713192592,-5.62899017903975,-1.22913827459878,"ATP2A3","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3",TRUE
+"207522_s_at",0.843461221384182,0.43818459460232,-0.789505096681155,-5.64056451003621,-1.34869232407191,"ATP2A3","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3",TRUE
+"213036_x_at",0.863408882018863,0.487906460307262,-0.705408716121712,-5.70018359348834,-1.12043057605347,"ATP2A3","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3",TRUE
+"230453_s_at",0.99753019043878,0.987629831586209,-0.0156802406037391,-5.93956372727337,-0.00504060550592778,"ATP2A3","ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3",TRUE
+"212930_at",0.828607509614823,0.398960893151071,0.860070896368962,-5.58567502758853,0.368770945999525,"ATP2B1","ATPase plasma membrane Ca2+ transporting 1",TRUE
+"209281_s_at",0.864079461576774,0.491200191189754,0.700020006800099,-5.70378646513542,0.274521539075675,"ATP2B1","ATPase plasma membrane Ca2+ transporting 1",TRUE
+"215716_s_at",0.923376218980614,0.671148567586384,0.430279579091495,-5.84990846826763,0.196718951634232,"ATP2B1","ATPase plasma membrane Ca2+ transporting 1",TRUE
+"234741_at",0.768882610729436,0.274280501868622,1.1210257811562,-5.34545424648643,0.839694706314893,"ATP2B2","ATPase plasma membrane Ca2+ transporting 2",TRUE
+"239357_at",0.775351898377291,0.292300929663516,1.07875571153664,-5.38823946339189,0.41252199694263,"ATP2B2","ATPase plasma membrane Ca2+ transporting 2",TRUE
+"234714_x_at",0.79845749620787,0.332979046566724,-0.989757425142417,-5.47348847727084,-0.425809876318632,"ATP2B2","ATPase plasma membrane Ca2+ transporting 2",TRUE
+"211586_s_at",0.900539767634459,0.595550378017865,-0.538574773517383,-5.79938361355341,-0.305104478675733,"ATP2B2","ATPase plasma membrane Ca2+ transporting 2",TRUE
+"204685_s_at",0.97345342693821,0.87184605190648,-0.163192698184926,-5.92672040378912,-0.110359134812739,"ATP2B2","ATPase plasma membrane Ca2+ transporting 2",TRUE
+"216120_s_at",0.975913043793143,0.884807341043886,-0.146556562524952,-5.9292273482077,-0.107806797653391,"ATP2B2","ATPase plasma membrane Ca2+ transporting 2",TRUE
+"215911_x_at",0.812302873476553,0.357590160783765,-0.939528041174537,-5.51865570251476,-0.689642918680735,"ATP2B3","ATPase plasma membrane Ca2+ transporting 3",TRUE
+"242036_x_at",0.835838027302116,0.415432284770785,-0.829928188381485,-5.60965921404637,-0.652260638028106,"ATP2B3","ATPase plasma membrane Ca2+ transporting 3",TRUE
+"216312_at",0.906313846447111,0.613044444136324,0.512976715105121,-5.81232159590922,0.490501693770484,"ATP2B3","ATPase plasma membrane Ca2+ transporting 3",TRUE
+"207026_s_at",0.956398858120188,0.802503252073866,0.253127800303384,-5.90852364853519,0.166775975269962,"ATP2B3","ATPase plasma membrane Ca2+ transporting 3",TRUE
+"205410_s_at",0.801086839730802,0.337263347193178,0.980835245426959,-5.48166819172636,0.656111164155099,"ATP2B4","ATPase plasma membrane Ca2+ transporting 4",TRUE
+"212135_s_at",0.868285886165517,0.502424774191165,0.681809686946872,-5.71576663755857,0.300940388177604,"ATP2B4","ATPase plasma membrane Ca2+ transporting 4",TRUE
+"212136_at",0.90415231543826,0.60647122734943,0.52255334777235,-5.80755311133812,0.250591195171296,"ATP2B4","ATPase plasma membrane Ca2+ transporting 4",TRUE
+"209935_at",0.398419196938932,0.0138383627058951,2.67316849789223,-2.95410104677874,1.11350512396765,"ATP2C1","ATPase secretory pathway Ca2+ transporting 1",TRUE
+"209934_s_at",0.515810181619652,0.0361703897857265,2.2302836853017,-3.7699612384129,0.789218336246371,"ATP2C1","ATPase secretory pathway Ca2+ transporting 1",TRUE
+"211137_s_at",0.55937703282623,0.0533671006737266,2.04074646471392,-4.09234677810272,0.77200807760701,"ATP2C1","ATPase secretory pathway Ca2+ transporting 1",TRUE
+"212255_s_at",0.734913444725244,0.219925320626782,1.26241592003423,-5.19190432599445,0.442888629702946,"ATP2C1","ATPase secretory pathway Ca2+ transporting 1",TRUE
+"236171_at",0.816358096928248,0.367569251349677,0.919827783625297,-5.53578144150302,0.716038508565094,"ATP2C2","ATPase secretory pathway Ca2+ transporting 2",TRUE
+"214798_at",0.967622663413673,0.84779142328612,-0.194196595426626,-5.92133187625968,-0.0991081231080404,"ATP2C2","ATPase secretory pathway Ca2+ transporting 2",TRUE
+"206043_s_at",0.968451827985008,0.852034303326604,-0.188714687189216,-5.92235245925913,-0.251472466792496,"ATP2C2","ATPase secretory pathway Ca2+ transporting 2",TRUE
+"207139_at",0.950120542813238,0.773303413903778,-0.291602211853711,-5.89835225494617,-0.218832070310373,"ATP4A","ATPase H+/K+ transporting alpha subunit",TRUE
+"207546_at",0.72050514215489,0.196494818915476,1.33170799572371,-5.11095380887121,0.893748969252607,"ATP4B","ATPase H+/K+ transporting beta subunit",TRUE
+"1563405_at",0.789406360796076,0.316159028105806,-1.0255752389788,-5.43997535521953,-0.423178645404265,"ATP4B","ATPase H+/K+ transporting beta subunit",TRUE
+"1563407_x_at",0.97689149311934,0.890086551121277,-0.139792955725591,-5.93016973874029,-0.0561050927405993,"ATP4B","ATPase H+/K+ transporting beta subunit",TRUE
+"213738_s_at",0.588653540532996,0.0674838663385609,-1.92256464936114,-4.28380883332415,-0.469584761828999,"ATP5A1","ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle",TRUE
+"1569891_at",0.839554522305768,0.428266304172582,-0.80696181237917,-5.62739573179795,-0.629592184518322,"ATP5A1","ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle",TRUE
+"201322_at",0.744706562599365,0.236235768115654,-1.21746387754317,-5.24243763640057,-0.343467625248714,"ATP5B","ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide",TRUE
+"214132_at",0.884881901304767,0.545009566098547,0.614707506025922,-5.757296299234,0.322722043109321,"ATP5C1","ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1",TRUE
+"213366_x_at",0.910602956673514,0.627738067773624,0.491742148278347,-5.82258795255351,0.13734502866073,"ATP5C1","ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1",TRUE
+"208870_x_at",0.925246803459608,0.676280530528693,0.423128102942644,-5.85285519970514,0.118653058357511,"ATP5C1","ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1",TRUE
+"205711_x_at",0.925511384407886,0.677461334043504,0.421485817144965,-5.8535250427975,0.126890695252866,"ATP5C1","ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1",TRUE
+"213041_s_at",0.942684843065067,0.743243522711197,-0.331685772036807,-5.88624060985679,-0.137937753663966,"ATP5D","ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit",TRUE
+"203926_x_at",0.993005393257451,0.966616059258309,-0.0423283784237449,-5.93881085149845,-0.0226969541717335,"ATP5D","ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit",TRUE
+"217801_at",0.732963666545614,0.217389314308478,-1.2696321239603,-5.18364576871148,-0.334874251184118,"ATP5E","ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit",TRUE
+"230535_s_at",0.909934011695618,0.625041819564615,-0.495621227461649,-5.82074414618424,-0.332207252646188,"ATP5E","ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit",TRUE
+"211755_s_at",0.648954261038999,0.119765488120318,-1.61821248435901,-4.73889026736876,-0.3596519821046,"ATP5F1","ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1",TRUE
+"243501_at",0.716472449896956,0.192257176196116,-1.34491998650481,-5.09510480180718,-0.571245128832813,"ATP5F1","ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1",TRUE
+"208972_s_at",0.813631136157676,0.36444127159582,-0.925963982311857,-5.53048294706907,-0.447557756720277,"ATP5G1","ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9)",TRUE
+"208764_s_at",0.622434989367596,0.0930473954434079,-1.75518079860835,-4.54121029083703,-0.789528640699885,"ATP5G2","ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9)",TRUE
+"207552_at",0.966064677476069,0.841945487651452,-0.201759715717731,-5.91987603690297,-0.151486753798445,"ATP5G2","ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9)",TRUE
+"217368_at",0.932969953191231,0.704074499106052,0.384772545271511,-5.86782996483525,0.12611838769794,"ATP5G2P1","ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) pseudogene 1",TRUE
+"228168_at",0.642592458809121,0.112917410582264,-1.65063909305676,-4.69319222157872,-0.732511179639456,"ATP5G3","ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9)",TRUE
+"207507_s_at",0.71454754703986,0.189661966411248,-1.35312457429166,-5.08519665404473,-0.304585400102814,"ATP5G3","ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9)",TRUE
+"207508_at",0.714791050845163,0.190231389991105,-1.3513168492295,-5.08738405764087,-0.322237479442302,"ATP5G3","ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9)",TRUE
+"1555998_at",0.915939421175188,0.645161702553877,0.46685509382517,-5.83408023426468,0.200585390835293,"ATP5H","ATP synthase, H+ transporting, mitochondrial Fo complex subunit D",TRUE
+"210149_s_at",0.957571530817866,0.80885445824475,-0.244812768417958,-5.91053427084439,-0.070699996451383,"ATP5H","ATP synthase, H+ transporting, mitochondrial Fo complex subunit D",TRUE
+"209492_x_at",0.424010380516768,0.0178906813114306,-2.55765502139376,-3.17433651806221,-0.934601241631109,"ATP5I","ATP synthase, H+ transporting, mitochondrial Fo complex subunit E",TRUE
+"207335_x_at",0.547793752989355,0.0482612870024544,-2.09045836666769,-4.00955537143755,-0.844974411415421,"ATP5I","ATP synthase, H+ transporting, mitochondrial Fo complex subunit E",TRUE
+"202325_s_at",0.95279845708016,0.783961791414368,-0.277509456051238,-5.90224347320734,-0.0665168423706621,"ATP5J","ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6",TRUE
+"1558179_at",0.82847108093969,0.398504014480892,-0.860918233355063,-5.58498928941597,-0.43426369097776,"ATP5J2","ATP synthase, H+ transporting, mitochondrial Fo complex subunit F2",TRUE
+"218956_s_at",0.562643595171948,0.0553227611823391,-2.0228257032559,-4.12187148192436,-0.668600790690821,"ATP5J2-PTCD1///PTCD1","ATP5J2-PTCD1 readthrough///pentatricopeptide repeat domain 1",TRUE
+"222796_at",0.862639573412331,0.486114070007679,0.708349968131081,-5.69820597518273,0.447652341034897,"ATP5J2-PTCD1///PTCD1","ATP5J2-PTCD1 readthrough///pentatricopeptide repeat domain 1",TRUE
+"208745_at",0.76524135343539,0.265405968522125,-1.14258956510269,-5.32306710622047,-0.553948544496134,"ATP5L","ATP synthase, H+ transporting, mitochondrial Fo complex subunit G",TRUE
+"208746_x_at",0.92051722798026,0.662166302267282,0.442851904949744,-5.84461053807344,0.137145513182674,"ATP5L","ATP synthase, H+ transporting, mitochondrial Fo complex subunit G",TRUE
+"210453_x_at",0.936143408699214,0.715234052142328,0.369539443775805,-5.87338842840867,0.109961192867447,"ATP5L","ATP synthase, H+ transporting, mitochondrial Fo complex subunit G",TRUE
+"207573_x_at",0.959451355429682,0.816766453275434,0.234478894171877,-5.91294000174875,0.0788135641750376,"ATP5L","ATP synthase, H+ transporting, mitochondrial Fo complex subunit G",TRUE
+"1564482_at",0.841550580403629,0.433041623957989,0.79852614059584,-5.63379313513722,0.501391369898862,"ATP5O","ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit",TRUE
+"200818_at",0.880913210934313,0.536813285082934,-0.627394496102336,-5.74976114997094,-0.16403228308152,"ATP5O","ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit",TRUE
+"216954_x_at",0.956239592379877,0.801753226365549,-0.25411093140789,-5.90828150967919,-0.0701113921587329,"ATP5O","ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit",TRUE
+"237400_at",0.522667179791589,0.0383759010450241,2.20189611799634,-3.81937981505698,1.01599982974647,"ATP5S","ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)",TRUE
+"238799_at",0.555096042605915,0.0513131648403158,-2.06021007813174,-4.06008633908973,-0.964718197784634,"ATP5S","ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)",TRUE
+"244670_at",0.579119470758542,0.062197058467313,1.9640068904446,-4.21755049087921,1.27707779934162,"ATP5S","ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)",TRUE
+"239859_x_at",0.680586794685785,0.148341158340567,-1.49763012131524,-4.9025796311178,-0.63059347911184,"ATP5S","ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)",TRUE
+"213995_at",0.748760747870936,0.24182800424104,-1.20259379103014,-5.25880532541489,-0.515628514561129,"ATP5S","ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)",TRUE
+"1554177_a_at",0.774230543658252,0.290071213752153,-1.08388198657132,-5.38312874005859,-0.484544948805382,"ATP5S","ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)",TRUE
+"206992_s_at",0.843850838418098,0.439872133310975,-0.786559272728815,-5.64276001866243,-0.319089998587884,"ATP5S","ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)",TRUE
+"206993_at",0.9181984176728,0.652681222740702,0.456207248844867,-5.83881870917443,0.129918815768027,"ATP5S","ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)",TRUE
+"45828_at",0.2073077623447,0.00235460668342128,-3.43374198299562,-1.41077192341095,-0.857799475038272,"ATP5SL","ATP5S like",TRUE
+"1557759_at",0.26392932766945,0.00399892198985608,-3.21127888411307,-1.87550879824829,-1.01150414145331,"ATP5SL","ATP5S like",TRUE
+"218038_at",0.429284714913652,0.0188683389754409,-2.53349307532117,-3.21979030296423,-0.746037132513555,"ATP5SL","ATP5S like",TRUE
+"242131_at",0.639705117673934,0.110225606552187,-1.66383949868708,-4.67439056227474,-0.651692730356332,"ATP6","ATP synthase F0 subunit 6",TRUE
+"1553567_s_at",0.934048461921637,0.707894177425502,-0.379548319845818,-5.86976119945693,-0.0841575703944724,"ATP6","ATP synthase F0 subunit 6",TRUE
+"207809_s_at",0.402463840838386,0.0148020615030824,-2.6430622838595,-3.0119540249863,-1.29196431607957,"ATP6AP1","ATPase H+ transporting accessory protein 1",TRUE
+"228816_at",0.937856707467078,0.725155780670704,-0.356070519205287,-5.87811855581642,-0.301075078944855,"ATP6AP1L","ATPase H+ transporting accessory protein 1 like",TRUE
+"1557523_at",0.99177641642161,0.962094807744666,-0.0480653325340387,-5.93855829304048,-0.0136577892675609,"ATP6AP1L","ATPase H+ transporting accessory protein 1 like",TRUE
+"201443_s_at",0.661121988136487,0.128821485904265,-1.57763347861338,-4.79508690620784,-0.448953895131195,"ATP6AP2","ATPase H+ transporting accessory protein 2",TRUE
+"201444_s_at",0.760237493549547,0.258292285609291,-1.16026114378009,-5.30444090603146,-0.390656671854787,"ATP6AP2","ATPase H+ transporting accessory protein 2",TRUE
+"201442_s_at",0.979588787486838,0.901932282082504,-0.124640243033512,-5.93211969393119,-0.0402710629426579,"ATP6AP2","ATPase H+ transporting accessory protein 2",TRUE
+"212383_at",0.739367922105944,0.227454980594091,-1.24135920954717,-5.21577176480926,-0.361872264416288,"ATP6V0A1","ATPase H+ transporting V0 subunit a1",TRUE
+"205095_s_at",0.820480477433428,0.379563346302573,-0.896614962251678,-5.5555311539824,-0.524590408235378,"ATP6V0A1","ATPase H+ transporting V0 subunit a1",TRUE
+"217603_at",0.789850877773366,0.318722192729632,1.02003259629993,-5.44523186843166,0.3387990700712,"ATP6V0A2","ATPase H+ transporting V0 subunit a2",TRUE
+"1555114_at",0.916349280948806,0.646746503229904,0.464606453642709,-5.83508983697343,0.337412562790874,"ATP6V0A2","ATPase H+ transporting V0 subunit a2",TRUE
+"205704_s_at",0.932918358096654,0.70391591392018,0.384989679252467,-5.8677491337273,0.137932955799457,"ATP6V0A2","ATPase H+ transporting V0 subunit a2",TRUE
+"235255_at",0.934926171367715,0.711006493304118,-0.375299508814236,-5.87131265430571,-0.294960625235679,"ATP6V0A2","ATPase H+ transporting V0 subunit a2",TRUE
+"205703_at",0.984244246588495,0.923315520948179,0.0973604337365689,-5.93506763739199,0.0667362105251899,"ATP6V0A2","ATPase H+ transporting V0 subunit a2",TRUE
+"229572_at",0.986889306520757,0.939579990153296,-0.0766626252754426,-5.93682133908951,-0.0853678291620952,"ATP6V0A2","ATPase H+ transporting V0 subunit a2",TRUE
+"220197_at",0.978240571220736,0.894475741911688,0.134174715205988,-5.93091875647563,0.17329751193765,"ATP6V0A4","ATPase H+ transporting V0 subunit a4",TRUE
+"200078_s_at",0.757479140651,0.253534583496464,-1.17228218493124,-5.2916272174649,-0.47707876647682,"ATP6V0B","ATPase H+ transporting V0 subunit b",TRUE
+"200954_at",0.740476003158683,0.229326836349251,-1.23620728197985,-5.22155882575574,-0.439924375786797,"ATP6V0C","ATPase H+ transporting V0 subunit c",TRUE
+"36994_at",0.813631136157676,0.364363898422759,-0.926116210889329,-5.53035108827992,-0.295771012795964,"ATP6V0C","ATPase H+ transporting V0 subunit c",TRUE
+"212041_at",0.490107603095446,0.0292280400513744,-2.33128728119491,-3.59108958669043,-0.923562475320987,"ATP6V0D1","ATPase H+ transporting V0 subunit d1",TRUE
+"1553155_x_at",0.731054546207485,0.2141258913914,1.27901403318374,-5.172848574047,0.373235416727776,"ATP6V0D2","ATPase H+ transporting V0 subunit d2",TRUE
+"1553153_at",0.743222421697179,0.23332025011857,1.22532209307218,-5.2337176888504,0.407962320949293,"ATP6V0D2","ATPase H+ transporting V0 subunit d2",TRUE
+"1553151_at",0.875938621758472,0.524204904885242,-0.647116433560118,-5.73775377080262,-0.51474036518087,"ATP6V0D2","ATPase H+ transporting V0 subunit d2",TRUE
+"236527_at",0.69114521567028,0.16082854990513,-1.45086574371209,-4.96333271112481,-0.409554376058456,"ATP6V0E1","ATPase H+ transporting V0 subunit e1",TRUE
+"200096_s_at",0.750269073377092,0.243202099623164,-1.19897967971957,-5.262757042881,-0.329214553688976,"ATP6V0E1","ATPase H+ transporting V0 subunit e1",TRUE
+"201172_x_at",0.819018525257656,0.373317363418303,-0.908641593526095,-5.54535694036337,-0.229755968065465,"ATP6V0E1","ATPase H+ transporting V0 subunit e1",TRUE
+"214150_x_at",0.820293495506061,0.379321468743207,-0.897078260408323,-5.55514153696268,-0.252655190129477,"ATP6V0E1","ATPase H+ transporting V0 subunit e1",TRUE
+"201171_at",0.908801761853008,0.621271279948848,0.501058858405454,-5.81813571518322,0.204182686030237,"ATP6V0E1","ATPase H+ transporting V0 subunit e1",TRUE
+"214244_s_at",0.951399215823566,0.777667715672081,0.285824502719547,-5.89997069218564,0.106153662116168,"ATP6V0E1","ATPase H+ transporting V0 subunit e1",TRUE
+"214149_s_at",0.994050962712312,0.972128807380128,0.035335277612875,-5.93907536086573,0.0197701517634687,"ATP6V0E1","ATPase H+ transporting V0 subunit e1",TRUE
+"213587_s_at",0.3983273585548,0.0138276237135256,-2.67351499039917,-2.95343341658798,-1.26556272957456,"ATP6V0E2","ATPase H+ transporting V0 subunit e2",TRUE
+"229094_at",0.642021982677251,0.112287911518593,-1.65370215414398,-4.68883961238898,-1.31005675085917,"ATP6V0E2-AS1","ATP6V0E2 antisense RNA 1",TRUE
+"201972_at",0.56861088242915,0.0582693037810805,-1.99686205258709,-4.16433952976059,-0.569791608856269,"ATP6V1A","ATPase H+ transporting V1 subunit A",TRUE
+"201971_s_at",0.789503009592599,0.316539758302528,-1.02474995291518,-5.44075966762605,-0.346879817339353,"ATP6V1A","ATPase H+ transporting V1 subunit A",TRUE
+"205473_at",0.904028854208405,0.606075494302864,-0.523131471261667,-5.80726249676967,-0.393937055565101,"ATP6V1B1","ATPase H+ transporting V1 subunit B1",TRUE
+"1554847_at",0.960031906173606,0.819160111572596,-0.231357720651507,-5.91364632325779,-0.207579539552908,"ATP6V1B1","ATPase H+ transporting V1 subunit B1",TRUE
+"201089_at",0.776955214137673,0.295736965591734,-1.07091068443777,-5.39601877280065,-0.364379839597786,"ATP6V1B2","ATPase H+ transporting V1 subunit B2",TRUE
+"226463_at",0.748760747870936,0.241912376056022,-1.20237143417199,-5.25904875169987,-0.502196776129972,"ATP6V1C1","ATPase H+ transporting V1 subunit C1",TRUE
+"202873_at",0.958640117088134,0.812576492674249,-0.2399480864403,-5.91167962265154,-0.088936420669647,"ATP6V1C1","ATPase H+ transporting V1 subunit C1",TRUE
+"202874_s_at",0.969946179106301,0.85793414919299,-0.18110172230731,-5.92372147918328,-0.076768388678877,"ATP6V1C1","ATPase H+ transporting V1 subunit C1",TRUE
+"202872_at",0.976140471115891,0.88530182974346,-0.145922742348402,-5.9293175466408,-0.0637512711398376,"ATP6V1C1","ATPase H+ transporting V1 subunit C1",TRUE
+"1553989_a_at",0.875604460253057,0.523045547841992,-0.648942803686942,-5.73662375170105,-0.341795071318193,"ATP6V1C2","ATPase H+ transporting V1 subunit C2",TRUE
+"1552532_a_at",0.937113154905832,0.719460039028088,-0.363794221055506,-5.87542728791467,-0.341722759149497,"ATP6V1C2","ATPase H+ transporting V1 subunit C2",TRUE
+"214923_at",0.546194603263057,0.0473918097463181,2.09939002052782,-3.99454381006972,0.55021872394173,"ATP6V1D","ATPase H+ transporting V1 subunit D",TRUE
+"208898_at",0.81035488031479,0.354158525380043,-0.946387830376759,-5.51261416180329,-0.330664141957342,"ATP6V1D","ATPase H+ transporting V1 subunit D",TRUE
+"208899_x_at",0.866484787547432,0.497513615646576,-0.689748544116108,-5.71058091071377,-0.224967121453711,"ATP6V1D","ATPase H+ transporting V1 subunit D",TRUE
+"235864_at",0.897699110987203,0.585186635176183,0.553911871937843,-5.79133841615868,0.366103072133464,"ATP6V1D","ATPase H+ transporting V1 subunit D",TRUE
+"208678_at",0.936495018406481,0.716617806677464,-0.367656845617905,-5.87405999668923,-0.116740092733933,"ATP6V1E1","ATPase H+ transporting V1 subunit E1",TRUE
+"1552286_at",0.932415412515157,0.702001793155445,0.387611973606047,-5.86676939921865,0.161107090699512,"ATP6V1E2","ATPase H+ transporting V1 subunit E2",TRUE
+"208737_at",0.692728103625751,0.162204910434495,-1.44589327110291,-4.96970063936635,-0.479736323092478,"ATP6V1G1","ATPase H+ transporting V1 subunit G1",TRUE
+"238765_at",0.854184492233394,0.46478021859419,-0.743854885425465,-5.67371642540648,-0.267886550740156,"ATP6V1G1","ATPase H+ transporting V1 subunit G1",TRUE
+"214762_at",0.769847953580141,0.277962108088013,1.11222965480693,-5.35447786725951,0.581750008903878,"ATP6V1G2","ATPase H+ transporting V1 subunit G2",TRUE
+"200041_s_at",0.835952408568777,0.416682190795985,0.827672075769873,-5.61142221459879,0.203696170306966,"ATP6V1G2-DDX39B///SNORD84///DDX39B","ATP6V1G2-DDX39B readthrough (NMD candidate)///small nucleolar RNA, C/D box 84///DEAD-box helicase 39B",TRUE
+"212384_at",0.951080114130021,0.776519731042782,-0.287343298747928,-5.89954836380301,-0.144128306513347,"ATP6V1G2-DDX39B///SNORD84///DDX39B","ATP6V1G2-DDX39B readthrough (NMD candidate)///small nucleolar RNA, C/D box 84///DEAD-box helicase 39B",TRUE
+"230565_at",0.853297110808539,0.460081141245479,0.751803958306067,-5.66807791849428,0.291817086644516,"ATP6V1G3","ATPase H+ transporting V1 subunit G3",TRUE
+"1557585_at",0.390415895588582,0.0130362521813515,-2.69977412225627,-2.90271940216177,-1.7580181554328,"ATP6V1H","ATPase H+ transporting V1 subunit H",TRUE
+"221504_s_at",0.657015752622694,0.125714299992151,-1.59128069000728,-4.77631130326231,-0.662331074577846,"ATP6V1H","ATPase H+ transporting V1 subunit H",TRUE
+"1557586_s_at",0.894400303187369,0.570857961825471,0.575341076252348,-5.77973057216849,0.17781697554075,"ATP6V1H","ATPase H+ transporting V1 subunit H",TRUE
+"205198_s_at",0.970893641742918,0.860959503585952,0.177202178940011,-5.92440096294754,0.0505767792430394,"ATP7A","ATPase copper transporting alpha",TRUE
+"205197_s_at",0.980009054680439,0.905250606252821,-0.120401049116725,-5.93262527824752,-0.0632777917483551,"ATP7A","ATPase copper transporting alpha",TRUE
+"204624_at",0.527546822913581,0.0400650229637709,-2.18114023739721,-3.85526749716562,-1.39955760156755,"ATP7B","ATPase copper transporting beta",TRUE
+"234383_x_at",0.973615804712521,0.873013803375941,-0.161691997788331,-5.92695757198215,-0.105618391065423,"ATP7B","ATPase copper transporting beta",TRUE
+"213106_at",0.516279980027392,0.0362694358168306,-2.22897549719536,-3.77224702963582,-1.94859796709801,"ATP8A1","ATPase phospholipid transporting 8A1",TRUE
+"210192_at",0.578441573439199,0.0617344588229338,-1.96777944305698,-4.21147098543453,-1.8322679456647,"ATP8A1","ATPase phospholipid transporting 8A1",TRUE
+"1569773_at",0.9116561917482,0.6303674470913,0.487966626884331,-5.82436894298288,0.472767833587184,"ATP8A1","ATPase phospholipid transporting 8A1",TRUE
+"231395_at",0.552420073963858,0.0498295566666314,-2.07470728017189,-4.03592778837943,-2.65951098911632,"ATP8A2","ATPase phospholipid transporting 8A2",TRUE
+"219659_at",0.808266620412549,0.351031011842445,-0.952678881895032,-5.50703810543877,-1.40004510192965,"ATP8A2","ATPase phospholipid transporting 8A2",TRUE
+"219660_s_at",0.83633038614858,0.4178572412729,-0.825554967451002,-5.61307250769512,-0.913616399060045,"ATP8A2","ATPase phospholipid transporting 8A2",TRUE
+"214594_x_at",0.529974080490865,0.0414421490663918,-2.1647969336073,-3.88337779276259,-0.748936502787284,"ATP8B1","ATPase phospholipid transporting 8B1",TRUE
+"226302_at",0.56559911410714,0.0565543574519183,-2.01182734710512,-4.13990586275616,-1.22030589341641,"ATP8B1","ATPase phospholipid transporting 8B1",TRUE
+"226771_at",0.720952283360079,0.196915628638505,-1.33040823383162,-5.11250588992289,-2.38187735671722,"ATP8B2","ATPase phospholipid transporting 8B2",TRUE
+"216873_s_at",0.88767000285873,0.552473454305508,-0.60324202966751,-5.76397825454744,-0.268574369073271,"ATP8B2","ATPase phospholipid transporting 8B2",TRUE
+"215319_at",0.55937703282623,0.053714090280369,2.03752454694528,-4.09766760761798,1.51647801773489,"ATP8B3","ATPase phospholipid transporting 8B3",TRUE
+"239457_at",0.662855903464759,0.130742628278317,1.56933172916753,-4.80644637280337,1.37043554348484,"ATP8B3","ATPase phospholipid transporting 8B3",TRUE
+"1554704_at",0.87825462101175,0.530585821071948,-0.637103661300178,-5.74389453672171,-0.621373954614318,"ATP8B3","ATPase phospholipid transporting 8B3",TRUE
+"220416_at",0.737123149977386,0.22296911026459,-1.25383858079005,-5.201668183024,-0.839763584965936,"ATP8B4","ATPase phospholipid transporting 8B4 (putative)",TRUE
+"1568686_at",0.86226540855538,0.485218469593477,0.709821966391546,-5.69721330009362,0.706028243443106,"ATP8B5P","ATPase phospholipid transporting 8B5, pseudogene",TRUE
+"1568687_s_at",0.86880806912978,0.505180047746423,0.677375022190209,-5.71863841172017,0.407523342944078,"ATP8B5P","ATPase phospholipid transporting 8B5, pseudogene",TRUE
+"216129_at",0.7768734672127,0.294589621036154,-1.07352296013672,-5.39343401695869,-0.930739463573776,"ATP9A","ATPase phospholipid transporting 9A (putative)",TRUE
+"212062_at",0.948567563026335,0.766042591781245,-0.301237109861634,-5.89558191488009,-0.409736428444157,"ATP9A","ATPase phospholipid transporting 9A (putative)",TRUE
+"1568723_at",0.666643938027574,0.133546480343573,1.55739516396234,-4.82269689619004,0.736398003672668,"ATP9B","ATPase phospholipid transporting 9B (putative)",TRUE
+"236762_at",0.73210946530771,0.215850106643993,1.27404353730178,-5.17857733331925,0.417096040291737,"ATP9B","ATPase phospholipid transporting 9B (putative)",TRUE
+"1564344_at",0.867857902063325,0.501063930396579,0.684005059550774,-5.71433834096846,0.25403930940747,"ATP9B","ATPase phospholipid transporting 9B (putative)",TRUE
+"214934_at",0.878281464330375,0.531241816312205,-0.636078013293675,-5.74451836229275,-0.474596188834614,"ATP9B","ATPase phospholipid transporting 9B (putative)",TRUE
+"237766_at",0.929088231432081,0.687470519720092,-0.407611526180081,-5.85908173525587,-0.317858131563158,"ATP9B","ATPase phospholipid transporting 9B (putative)",TRUE
+"214010_s_at",0.991689960875868,0.961319528933566,-0.0490492337886995,-5.93851175889025,-0.0273667133345601,"ATP9B","ATPase phospholipid transporting 9B (putative)",TRUE
+"224729_s_at",0.707898177720919,0.17981983919713,-1.38506844394032,-5.0461418398531,-0.53695744911183,"ATPAF1","ATP synthase mitochondrial F1 complex assembly factor 1",TRUE
+"224728_at",0.870433264908839,0.508833866122692,-0.671515078032846,-5.722405658684,-0.30591859404792,"ATPAF1","ATP synthase mitochondrial F1 complex assembly factor 1",TRUE
+"214330_at",0.969865240932986,0.856018050877057,0.18357296879289,-5.92328323974488,0.0717660100844162,"ATPAF2","ATP synthase mitochondrial F1 complex assembly factor 2",TRUE
+"213057_at",0.99783553534859,0.989566148389451,0.0132256309101576,-5.93959828533419,0.00607613094494042,"ATPAF2","ATP synthase mitochondrial F1 complex assembly factor 2",TRUE
+"223339_at",0.51470556386048,0.0353847537403357,-2.24077741951594,-3.75159637138819,-1.05983300484675,"ATPIF1","ATPase inhibitory factor 1",TRUE
+"218671_s_at",0.774209477315394,0.285942486087282,-1.09344960637016,-5.37353236977602,-0.393534846882389,"ATPIF1","ATPase inhibitory factor 1",TRUE
+"223338_s_at",0.820536502908875,0.379813227804254,-0.896136536899231,-5.55593329701879,-0.316555135742327,"ATPIF1","ATPase inhibitory factor 1",TRUE
+"209902_at",0.867972140419125,0.501473877001534,0.68334336106808,-5.71476930021699,0.208103765265966,"ATR","ATR serine/threonine kinase",TRUE
+"233288_at",0.877546037473893,0.528079417558623,0.64102877740885,-5.74149825558867,0.542042494544862,"ATR","ATR serine/threonine kinase",TRUE
+"209903_s_at",0.942303845415102,0.740801929508163,0.334965095078888,-5.8851814839767,0.0950058844423332,"ATR","ATR serine/threonine kinase",TRUE
+"219329_s_at",0.997901456792957,0.990313961362305,0.0122776743747629,-5.93961006049216,0.00425827810251,"ATRAID","all-trans retinoic acid induced differentiation factor",TRUE
+"1552937_s_at",0.7994347047598,0.334920165823247,-0.985705254129893,-5.47721179948909,-0.39634532902364,"ATRIP///TREX1","ATR interacting protein///three prime repair exonuclease 1",TRUE
+"205875_s_at",0.897560972979555,0.584571878648662,-0.554825835858352,-5.79085206316251,-0.640846083559009,"ATRIP///TREX1","ATR interacting protein///three prime repair exonuclease 1",TRUE
+"34689_at",0.955316686567461,0.7954395819265,0.262397093029203,-5.90620362595654,0.152988394687613,"ATRIP///TREX1","ATR interacting protein///three prime repair exonuclease 1",TRUE
+"211852_s_at",0.924509228034459,0.673904311265656,0.426436592697958,-5.85149798436947,0.155625252461981,"ATRN","attractin",TRUE
+"212517_at",0.942285666617422,0.740092791615034,0.335918244532723,-5.88487171101554,0.123935335471954,"ATRN","attractin",TRUE
+"1569796_s_at",0.740610299769501,0.230037969607946,-1.23425840718101,-5.22374255377931,-1.33604143499398,"ATRNL1","attractin like 1",TRUE
+"213745_at",0.833379627787261,0.410829101193417,-0.838274258688532,-5.60309831925413,-1.03157833888277,"ATRNL1","attractin like 1",TRUE
+"213744_at",0.953564723226096,0.786297661850283,0.27442866758556,-5.90306864779528,0.19522276249404,"ATRNL1","attractin like 1",TRUE
+"208860_s_at",0.841967750949524,0.43476095949923,-0.795503017827111,-5.63607041367021,-0.221802950594864,"ATRX","ATRX, chromatin remodeler",TRUE
+"208861_s_at",0.864894115958506,0.493717067122911,-0.695916243644366,-5.70651255059376,-0.186391820322147,"ATRX","ATRX, chromatin remodeler",TRUE
+"211022_s_at",0.872010957446544,0.51481740640909,0.661969387686452,-5.72847527546308,0.311245033421491,"ATRX","ATRX, chromatin remodeler",TRUE
+"208859_s_at",0.920119557710459,0.659894432500092,0.446043246189754,-5.84324189146385,0.162615154167742,"ATRX","ATRX, chromatin remodeler",TRUE
+"230507_at",0.583499660864496,0.0646195194477603,-1.94464706144186,-4.24862380382418,-1.21208539473686,"ATXN1","ataxin 1",TRUE
+"242230_at",0.597654932724127,0.0735817725942544,1.87816958730628,-4.35369970507815,0.999739640936069,"ATXN1","ataxin 1",TRUE
+"1559249_at",0.623503825356688,0.0943976818710549,1.74750142844631,-4.55261119081512,1.19980268584217,"ATXN1","ataxin 1",TRUE
+"203232_s_at",0.879960488971225,0.534981861461333,0.630243507703762,-5.74804866521503,0.386534553886893,"ATXN1","ataxin 1",TRUE
+"203231_s_at",0.929088231432081,0.687423362919748,0.407676700253862,-5.85905606057505,0.241564930181099,"ATXN1","ataxin 1",TRUE
+"208833_s_at",0.635626505801859,0.106630506694987,1.68190081650277,-4.64848105197463,0.483175660350641,"ATXN10","ataxin 10",TRUE
+"208832_at",0.827127572319186,0.395901757066175,0.865756409471821,-5.58106178518788,0.306294730223236,"ATXN10","ataxin 10",TRUE
+"226095_s_at",0.731054546207485,0.21416670439917,-1.27889602348257,-5.17298480692491,-0.445706867433518,"ATXN1L","ataxin 1 like",TRUE
+"227373_at",0.770727405547907,0.279111159210765,-1.10950171061076,-5.35726356244168,-0.462445246340733,"ATXN1L","ataxin 1 like",TRUE
+"202622_s_at",0.954456115752166,0.791348226532868,0.267776678816206,-5.90481915638673,0.0760526893161781,"ATXN2","ataxin 2",TRUE
+"201806_s_at",0.780323446630392,0.301837651453058,-1.05714092290668,-5.40955024427716,-0.316847567168986,"ATXN2L","ataxin 2 like",TRUE
+"207798_s_at",0.822173415758858,0.386376855144463,0.883642971578902,-5.56636445935322,0.449101292183377,"ATXN2L","ataxin 2 like",TRUE
+"205416_s_at",0.809707978333974,0.353079749152876,-0.948553548997107,-5.51069840415243,-0.39592662260201,"ATXN3","ataxin 3",TRUE
+"233182_x_at",0.917806614232276,0.651013121471692,-0.458564664470041,-5.8377788503298,-0.173581483897912,"ATXN3","ataxin 3",TRUE
+"238723_at",0.928246500493356,0.684736999820831,0.41139242415513,-5.8575856086681,0.213228765636818,"ATXN3","ataxin 3",TRUE
+"216657_at",0.9941582295447,0.973396716259265,-0.0337271622204854,-5.93912945116804,-0.0139459352781177,"ATXN3","ataxin 3",TRUE
+"205415_s_at",0.997056683282451,0.984954275601226,-0.0190721269611949,-5.9395063150236,-0.0082381192634422,"ATXN3","ataxin 3",TRUE
+"235240_at",0.997171203405,0.985688525879585,-0.0181412737151979,-5.93952318671335,-0.00917523644711871,"ATXN3","ataxin 3",TRUE
+"217321_x_at",0.997470525710394,0.987207063119172,-0.0162161838789227,-5.93955540118993,-0.0122411307837735,"ATXN3","ataxin 3",TRUE
+"216539_at",0.88166256834198,0.538537601259394,0.624716875316235,-5.75136380582141,0.394968350462538,"ATXN3L","ataxin 3 like",TRUE
+"209964_s_at",0.653206225743412,0.12248963007367,-1.60574416802948,-4.75627525352377,-0.504488919216972,"ATXN7","ataxin 7",TRUE
+"204516_at",0.716529083807557,0.192542209406504,-1.34402418905036,-5.09618354178049,-0.683946455464222,"ATXN7","ataxin 7",TRUE
+"243259_at",0.952339611416198,0.781837250478086,-0.280313904639041,-5.90148436498762,-0.0991244497577526,"ATXN7","ataxin 7",TRUE
+"227732_at",0.519956259865057,0.0376196145014223,-2.21145936813354,-3.80277460061127,-0.936420402821622,"ATXN7L1","ataxin 7 like 1",TRUE
+"214343_s_at",0.734577729521114,0.219039989426083,-1.2649278374234,-5.18903414040525,-1.00547400131021,"ATXN7L1","ataxin 7 like 1",TRUE
+"214342_at",0.821187434813103,0.382366630868243,-0.891259571847774,-5.56002132304925,-0.513402886707019,"ATXN7L1","ataxin 7 like 1",TRUE
+"232265_at",0.924438662713252,0.67374543816731,-0.426657969299644,-5.85140680003319,-0.178739524995906,"ATXN7L1","ataxin 7 like 1",TRUE
+"230038_at",0.775351898377291,0.292231346352993,-1.07891526308575,-5.38808072204065,-0.466972257397034,"ATXN7L2","ataxin 7 like 2",TRUE
+"224969_at",0.839519981963042,0.427220810511767,0.808816477413564,-5.62598073399478,0.227636158786899,"ATXN7L3","ataxin 7 like 3",TRUE
+"212114_at",0.724067243569133,0.201392707927146,-1.31671248783167,-5.12878272511102,-0.532539995387447,"ATXN7L3B","ataxin 7 like 3B",TRUE
+"212113_at",0.95238233774064,0.782155125360441,-0.279894156095182,-5.9015984646078,-0.190338644974272,"ATXN7L3B","ataxin 7 like 3B",TRUE
+"216404_at",0.643688366500038,0.114675411783142,1.64216037532706,-4.70520827341669,1.23192786489219,"ATXN8OS","ATXN8 opposite strand (non-protein coding)",TRUE
+"205052_at",0.839144304920419,0.424997621354391,-0.812769749590065,-5.62295445141281,-0.321934191487163,"AUH","AU RNA binding methylglutaconyl-CoA hydratase",TRUE
+"222946_s_at",0.826134344333512,0.393941886168277,0.869413813481624,-5.57807921704749,0.386360290952569,"AUNIP","aurora kinase A and ninein interacting protein",TRUE
+"220011_at",0.966051687342135,0.841607975205735,0.202196732556126,-5.91979022159627,0.0660854693974464,"AUNIP","aurora kinase A and ninein interacting protein",TRUE
+"220525_s_at",0.849466402905097,0.450578420679483,-0.768028993709573,-5.65639306924544,-0.180878546187753,"AUP1","ancient ubiquitous protein 1",TRUE
+"208080_at",0.823073978212882,0.388933495071637,0.878814058975042,-5.57035985152547,0.335089639000575,"AURKA","aurora kinase A",TRUE
+"204092_s_at",0.892746695408886,0.565621371728859,-0.583240500837414,-5.77534393173419,-0.219793329797028,"AURKA","aurora kinase A",TRUE
+"208079_s_at",0.913299709879835,0.636334957546944,-0.479424395716312,-5.82834896053143,-0.222157805723814,"AURKA","aurora kinase A",TRUE
+"225555_x_at",0.617775129514679,0.0885600538401588,1.78140775027209,-4.50199658621322,0.663543806834589,"AURKAIP1","aurora kinase A interacting protein 1",TRUE
+"222677_x_at",0.897726361369233,0.585365203642881,-0.553646482037619,-5.79147949381639,-0.267943221680292,"AURKAIP1","aurora kinase A interacting protein 1",TRUE
+"228800_x_at",0.937113154905832,0.720515116422407,0.362361796557911,-5.87593071335877,0.141471411709949,"AURKAIP1","aurora kinase A interacting protein 1",TRUE
+"227546_x_at",0.954723352940649,0.793995706354459,-0.264294684959474,-5.9057184547327,-0.0614510948609297,"AURKAIP1","aurora kinase A interacting protein 1",TRUE
+"218580_x_at",0.955735662836499,0.797823348135545,0.25926641313947,-5.90699647820837,0.0731646618405009,"AURKAIP1","aurora kinase A interacting protein 1",TRUE
+"225552_x_at",0.981335195954425,0.911645718816058,0.112237525580111,-5.93354968081816,0.0338983295705138,"AURKAIP1","aurora kinase A interacting protein 1",TRUE
+"209464_at",0.73223722457785,0.216304922244817,1.27273751104956,-5.18007943938813,0.682383256266307,"AURKB","aurora kinase B",TRUE
+"239219_at",0.762209577303903,0.261611795659534,1.15197077486806,-5.31321040963728,0.793212387567562,"AURKB","aurora kinase B",TRUE
+"211107_s_at",0.607377668936197,0.0809627843983174,1.82854449474765,-4.43045768525525,1.16581166336025,"AURKC","aurora kinase C",TRUE
+"243364_at",0.697172073261335,0.166823286128618,-1.42945279202709,-4.9906278551227,-1.07450311008214,"AUTS2","autism susceptibility candidate 2",TRUE
+"212599_at",0.817857130700434,0.370624825188521,-0.913867103903628,-5.54089729505369,-1.49191051510861,"AUTS2","autism susceptibility candidate 2",TRUE
+"243365_s_at",0.983679139992471,0.920385436938177,-0.101093561671544,-5.93470696587711,-0.067751714659809,"AUTS2","autism susceptibility candidate 2",TRUE
+"219366_at",0.839466826665106,0.425444958071767,0.811973261249162,-5.62356528754226,0.380077372433977,"AVEN","apoptosis and caspase activation inhibitor",TRUE
+"233333_x_at",0.805746717966166,0.345897325395112,-0.963088277414911,-5.49773751399,-0.30810361960418,"AVIL","advillin",TRUE
+"210507_s_at",0.993083193605528,0.9672082609734,-0.0415770538372911,-5.93884155345781,-0.0336125365399589,"AVIL","advillin",TRUE
+"205539_at",0.993474831312851,0.969393176670517,0.0388052663987637,-5.93895006398262,0.0313050048118955,"AVIL","advillin",TRUE
+"212474_at",0.391240007651669,0.0131161168545284,-2.69705678168052,-2.90797804198407,-1.15280326123387,"AVL9","AVL9 cell migration associated",TRUE
+"1555055_at",0.610455440146151,0.0829749405398,-1.81569965664987,-4.45008594296117,-2.0855534466213,"AVL9","AVL9 cell migration associated",TRUE
+"212475_at",0.620912785033482,0.0906403170729541,-1.76911067549169,-4.52043590593237,-1.07280889082175,"AVL9","AVL9 cell migration associated",TRUE
+"212471_at",0.839519981963042,0.427616162435143,-0.808114806714765,-5.62651642512067,-0.3769948481569,"AVL9","AVL9 cell migration associated",TRUE
+"244355_at",0.934627839382205,0.709895409389469,0.376815505283503,-5.87076106445472,0.265275446436627,"AVL9","AVL9 cell migration associated",TRUE
+"1563452_at",0.94333312187812,0.745547040284303,0.328595297163516,-5.88722930642542,0.247609499102477,"AVL9","AVL9 cell migration associated",TRUE
+"207848_at",0.938495321213615,0.726387654378011,0.354402954340318,-5.87869211909987,0.179275422159944,"AVP","arginine vasopressin",TRUE
+"218631_at",0.122997672287767,0.000695130877675718,3.93731137646191,-0.335817287630258,1.44242154836042,"AVPI1","arginine vasopressin induced 1",TRUE
+"206252_s_at",0.41572201307165,0.0169102104631248,2.58316054585712,-3.12611952252861,1.49078679219891,"AVPR1A","arginine vasopressin receptor 1A",TRUE
+"238835_at",0.580630437263151,0.0632501181065056,1.95551068973594,-4.23121311130443,1.73965687945997,"AVPR1A","arginine vasopressin receptor 1A",TRUE
+"206251_s_at",0.739189560382301,0.226297512020397,1.24456109975884,-5.21216470801376,0.881933531509477,"AVPR1A","arginine vasopressin receptor 1A",TRUE
+"242680_at",0.760325881249847,0.258980971124775,1.1585347191762,-5.30627165862904,0.704411043436004,"AVPR1A","arginine vasopressin receptor 1A",TRUE
+"206250_x_at",0.933448396773721,0.70558580616805,0.382704214738675,-5.8685976754901,0.292697285339306,"AVPR1A","arginine vasopressin receptor 1A",TRUE
+"208260_at",0.940227139261806,0.732363690728026,0.346327721197152,-5.88143197794214,0.245221329971028,"AVPR1B","arginine vasopressin receptor 1B",TRUE
+"208111_at",0.835087155533826,0.413986317892443,0.832543549931422,-5.60760986644754,0.477394362257207,"AVPR2","arginine vasopressin receptor 2",TRUE
+"208108_s_at",0.867580082241907,0.500227633863498,0.685355884824688,-5.71345732106573,0.249717503115406,"AVPR2","arginine vasopressin receptor 2",TRUE
+"1560507_at",0.861659105448003,0.483300742868073,0.712979219246316,-5.69507751721037,0.385246155430256,"AWAT1","acyl-CoA wax alcohol acyltransferase 1",TRUE
+"1552870_s_at",0.823074246722209,0.389312932342474,-0.878099151077539,-5.57094963269809,-0.604383256160346,"AXDND1","axonemal dynein light chain domain containing 1",TRUE
+"1553376_a_at",0.932249295738588,0.701096398832418,0.38885330310763,-5.86630333114557,0.406644109376285,"AXDND1","axonemal dynein light chain domain containing 1",TRUE
+"212849_at",0.672164152353115,0.138036430612305,-1.53870502922011,-4.84794504458733,-1.17228616300099,"AXIN1","axin 1",TRUE
+"222696_at",0.7974001826642,0.330652280872357,-0.994636188000261,-5.46898722010414,-0.88702575677141,"AXIN2","axin 2",TRUE
+"224498_x_at",0.946249475978621,0.756303794438237,-0.314206249053583,-5.89171196416835,-0.236569287072431,"AXIN2","axin 2",TRUE
+"224176_s_at",0.951920215149949,0.779712755652041,-0.283120590180171,-5.90071706730301,-0.178815134600914,"AXIN2","axin 2",TRUE
+"222695_s_at",0.961395512423249,0.825070875838861,0.223660456282628,-5.91534796372412,0.125375901320949,"AXIN2","axin 2",TRUE
+"202686_s_at",0.451692529012709,0.0216448911936589,2.4707500699488,-3.33677847359954,3.58659913245708,"AXL","AXL receptor tyrosine kinase",TRUE
+"202685_s_at",0.625531708587096,0.0967214460794753,1.73450317481958,-4.57182424745761,1.84764129988791,"AXL","AXL receptor tyrosine kinase",TRUE
+"209309_at",0.899229764439207,0.589585525297059,-0.54738583835544,-5.79478852265857,-1.05236495600787,"AZGP1","alpha-2-glycoprotein 1, zinc-binding",TRUE
+"217013_at",0.819479221404744,0.376825535480409,-0.901870423915844,-5.55110058272512,-0.754135035548456,"AZGP1P1","alpha-2-glycoprotein 1, zinc-binding pseudogene 1",TRUE
+"217014_s_at",0.888750194607196,0.555316233778352,-0.598896594851534,-5.76647898974102,-0.830565095582267,"AZGP1P1///AZGP1","alpha-2-glycoprotein 1, zinc-binding pseudogene 1///alpha-2-glycoprotein 1, zinc-binding",TRUE
+"227904_at",0.697172073261335,0.166909615499301,1.42914898059626,-4.9910127375574,0.628601454332159,"AZI2","5-azacytidine induced 2",TRUE
+"227905_s_at",0.828607509614823,0.398953158739218,0.86008523557796,-5.58566342829215,0.319688752122486,"AZI2","5-azacytidine induced 2",TRUE
+"223846_at",0.837015771520825,0.419133995917257,0.823258861778529,-5.61485785664448,0.400894425565014,"AZI2","5-azacytidine induced 2",TRUE
+"222498_at",0.889774397983275,0.558002148797758,-0.594801600866538,-5.76881961544212,-0.206779374273896,"AZI2","5-azacytidine induced 2",TRUE
+"235962_at",0.992376456171815,0.964368856469582,0.0451796289726392,-5.93868933693864,0.0185896447374345,"AZI2","5-azacytidine induced 2",TRUE
+"218043_s_at",0.99691938672319,0.984447638016859,0.0197144319227462,-5.93949418113764,0.00703865065165843,"AZI2","5-azacytidine induced 2",TRUE
+"212461_at",0.851159202728357,0.45434076509606,0.761580725944739,-5.66106519074701,0.25633670885132,"AZIN1","antizyme inhibitor 1",TRUE
+"213747_at",0.940141069703974,0.731839854918534,0.347034618528923,-5.88119462621588,0.257799574367277,"AZIN1","antizyme inhibitor 1",TRUE
+"201772_at",0.954627246077849,0.793296550993088,0.265213895443983,-5.90548218497652,0.0870475791272192,"AZIN1","antizyme inhibitor 1",TRUE
+"1554393_a_at",0.921729477898827,0.66635923536448,-0.436974224495955,-5.8471060146544,-0.207992762694094,"AZIN2","antizyme inhibitor 2",TRUE
+"228000_at",0.93032716386748,0.691953797108881,0.401423463568865,-5.8615010568778,0.163733328057177,"AZIN2","antizyme inhibitor 2",TRUE
+"214575_s_at",0.982090256251837,0.913941185703698,-0.109309237844005,-5.93386547751103,-0.0885554482537296,"AZU1","azurocidin 1",TRUE
+"232311_at",0.462383788065866,0.0233242704615575,2.43634527945365,-3.4002675054168,1.48130741397262,"B2M","beta-2-microglobulin",TRUE
+"201891_s_at",0.689985677226298,0.159447400195823,1.45589017654605,-4.95688017892476,0.423013833638898,"B2M","beta-2-microglobulin",TRUE
+"216231_s_at",0.698391916012681,0.1694707883964,1.42019252129198,-5.00232906589995,0.481110059987284,"B2M","beta-2-microglobulin",TRUE
+"223374_s_at",0.959451355429682,0.816906803803613,0.234295820852769,-5.9129816911679,0.318484424647355,"B3GALNT1","beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)",TRUE
+"211379_x_at",0.988391891288248,0.944553750705276,-0.0703403985779456,-5.93727389089777,-0.0741291016664274,"B3GALNT1","beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)",TRUE
+"211812_s_at",0.997608949249317,0.987913155918966,-0.0153210731993711,-5.9395691504936,-0.0143325037730317,"B3GALNT1","beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)",TRUE
+"1561714_a_at",0.774230543658252,0.286217925447443,1.09280823228346,-5.37417802053895,0.730253545204603,"B3GALNT2","beta-1,3-N-acetylgalactosaminyltransferase 2",TRUE
+"1562391_at",0.845487921422997,0.442711786082678,0.781617878372743,-5.64642545290793,0.277128769264483,"B3GALNT2","beta-1,3-N-acetylgalactosaminyltransferase 2",TRUE
+"1553691_at",0.867580082241907,0.500306324584367,-0.68522872536598,-5.71354032638644,-0.265949872848155,"B3GALNT2","beta-1,3-N-acetylgalactosaminyltransferase 2",TRUE
+"226233_at",0.919980097937101,0.659441061147744,-0.446680668609537,-5.84296736975174,-0.155780440573093,"B3GALNT2","beta-1,3-N-acetylgalactosaminyltransferase 2",TRUE
+"222969_at",0.571736836402345,0.0597931637960422,1.98388875480173,-4.18542177529368,0.63383776310557,"B3GALT1","beta-1,3-galactosyltransferase 1",TRUE
+"220829_s_at",0.849935057946582,0.451460026386986,-0.766515103562827,-5.65749330855272,-0.54194028282062,"B3GALT1","beta-1,3-galactosyltransferase 1",TRUE
+"217452_s_at",0.617775129514679,0.0884228032670642,1.78222779226594,-4.50076362235581,1.70305600811438,"B3GALT2","beta-1,3-galactosyltransferase 2",TRUE
+"210121_at",0.777463110382572,0.296365978570701,1.0694816237423,-5.3974303947498,1.13832956768879,"B3GALT2","beta-1,3-galactosyltransferase 2",TRUE
+"216065_at",0.784552021081681,0.308362625805608,1.04263088182691,-5.42363906100412,0.384772686446101,"B3GALT4","beta-1,3-galactosyltransferase 4",TRUE
+"210205_at",0.85334340854827,0.461232239582499,0.749852269404321,-5.66946756589254,0.876305801726756,"B3GALT4","beta-1,3-galactosyltransferase 4",TRUE
+"239994_at",0.766390367856479,0.266840644466668,-1.13906802295441,-5.32674881593687,-1.11381954769057,"B3GALT5","beta-1,3-galactosyltransferase 5",TRUE
+"206947_at",0.930827859648584,0.693671561843205,-0.399056744417862,-5.86241673040433,-0.218805880237364,"B3GALT5","beta-1,3-galactosyltransferase 5",TRUE
+"230269_at",0.968482638277755,0.85222063475723,-0.188474079114546,-5.92239658685192,-0.267168305685259,"B3GALT5","beta-1,3-galactosyltransferase 5",TRUE
+"1553850_at",0.968980656821882,0.853338695054525,0.187030576629159,-5.92266014761983,0.128091090693832,"B3GALT5-AS1","B3GALT5 antisense RNA 1",TRUE
+"1555231_a_at",0.97070558355376,0.860330618346757,-0.178012549688809,-5.92426097194967,-0.146006528968307,"B3GALT5-AS1","B3GALT5 antisense RNA 1",TRUE
+"1553959_a_at",0.689985677226298,0.159464843674396,-1.45582650068874,-4.9569620668624,-0.467040795349522,"B3GALT6","beta-1,3-galactosyltransferase 6",TRUE
+"226427_s_at",0.769258076576208,0.275582280979075,-1.11790577704557,-5.34866214858901,-0.412881786179984,"B3GALT6","beta-1,3-galactosyltransferase 6",TRUE
+"225733_at",0.861659105448003,0.482697744127187,-0.713973468296802,-5.69440307038597,-0.256975661126672,"B3GALT6","beta-1,3-galactosyltransferase 6",TRUE
+"219521_at",0.840616438821329,0.429795619011562,-0.80425393193253,-5.62945620351555,-0.758937411773211,"B3GAT1","beta-1,3-glucuronyltransferase 1",TRUE
+"234146_at",0.666021473381655,0.133045511487042,1.55951257294011,-4.81982136415533,0.883000894911348,"B3GAT2","beta-1,3-glucuronyltransferase 2",TRUE
+"239144_at",0.769393110223875,0.276772097234646,1.11506350400746,-5.35157760258687,0.700465399007718,"B3GAT2","beta-1,3-glucuronyltransferase 2",TRUE
+"35179_at",0.622917527985155,0.0936347257623126,-1.75182886579395,-4.54619115495432,-0.667533952537701,"B3GAT3","beta-1,3-glucuronyltransferase 3",TRUE
+"203452_at",0.835952408568777,0.416614238530929,-0.827794621537835,-5.61132656864439,-0.459027291500178,"B3GAT3","beta-1,3-glucuronyltransferase 3",TRUE
+"227083_at",0.845588139978284,0.442926380054504,0.781245243890799,-5.6467009834627,0.426847653881681,"B3GLCT","beta 3-glucosyltransferase",TRUE
+"227100_at",0.85334340854827,0.461538853093151,0.749332896687329,-5.66983679491576,0.28276074911915,"B3GLCT","beta 3-glucosyltransferase",TRUE
+"219326_s_at",0.821424121108148,0.383598801267319,0.888913778836975,-5.56198028374179,0.306752312332351,"B3GNT2","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2",TRUE
+"224154_at",0.841813886364358,0.433853945036863,0.797096906961512,-5.6348707703238,0.633351280765912,"B3GNT2","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2",TRUE
+"222870_s_at",0.896690757315733,0.581599499628186,0.559251663464094,-5.78848591347231,0.156274200693623,"B3GNT2","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2",TRUE
+"204856_at",0.402425985522398,0.0146202456938505,2.64859814778131,-3.00133951567776,2.19060494333609,"B3GNT3","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3",TRUE
+"221240_s_at",0.888583087185673,0.554711718370813,0.599819673101784,-5.76594923204447,0.223069221777244,"B3GNT4","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4",TRUE
+"225612_s_at",0.358427723880268,0.010021010824127,2.81597028021542,-2.67564454142177,3.85290778323068,"B3GNT5","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5",TRUE
+"1554835_a_at",0.412728274083545,0.0165738834598871,2.59222966712726,-3.10891735572467,2.60586035932824,"B3GNT5","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5",TRUE
+"1556134_a_at",0.688388924996666,0.157751082696275,1.46210951821508,-4.94886801894391,1.06899256259152,"B3GNT5","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5",TRUE
+"1552833_at",0.9116561917482,0.630155036299991,0.488271359556416,-5.82422569199811,0.259107903509584,"B3GNT6","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6",TRUE
+"1552834_at",0.93667390723462,0.717205788014423,-0.366857306957778,-5.87434418721507,-0.285080036270112,"B3GNT6","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6",TRUE
+"1555962_at",0.194325783329824,0.00204280414973504,3.4929125602637,-1.28585536192068,3.75328454027032,"B3GNT7","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7",TRUE
+"1555963_x_at",0.2443484198961,0.00328032446646067,3.29485019339483,-1.70192032924731,2.81326826515938,"B3GNT7","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7",TRUE
+"232337_at",0.852994610926182,0.459230936932457,0.753247356734487,-5.66704798572021,0.271437315887459,"B3GNT7","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7",TRUE
+"1552965_a_at",0.858826390511142,0.475036700722505,0.726668820186242,-5.68571262549214,0.566093693850761,"B3GNT7","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7",TRUE
+"237338_at",0.708894565317004,0.181484266984315,-1.37957066653829,-5.05291743922297,-1.0797255284992,"B3GNT8","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8",TRUE
+"226058_at",0.812302873476553,0.360284057518744,0.934173957726214,-5.52334310233507,0.492780833820374,"B3GNT9","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9",TRUE
+"213589_s_at",0.425751189365875,0.0181914265104271,2.550093542385,-3.18858483225672,2.62979166620447,"B3GNTL1","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1",TRUE
+"215055_at",0.904832003218088,0.609721791902422,0.517811415412488,-5.80992499975465,0.17918156400451,"B3GNTL1","UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1",TRUE
+"206435_at",0.877272789877247,0.526732714148885,0.643141951290601,-5.74020230669089,0.419779919054174,"B4GALNT1","beta-1,4-N-acetyl-galactosaminyltransferase 1",TRUE
+"1555385_at",0.973786219280202,0.873549020521922,0.16100430693224,-5.9270655232762,0.0998151412890733,"B4GALNT1","beta-1,4-N-acetyl-galactosaminyltransferase 1",TRUE
+"1552903_at",0.748237011093779,0.240795548909315,1.2053195031544,-5.25581816206711,1.07523474565535,"B4GALNT2","beta-1,4-N-acetyl-galactosaminyltransferase 2",TRUE
+"229203_at",0.624331975868069,0.0956320079555694,1.74056342252174,-4.56287966295757,1.62443456245696,"B4GALNT3","beta-1,4-N-acetyl-galactosaminyltransferase 3",TRUE
+"229909_at",0.713005775571409,0.187615291753131,1.35965757479714,-5.07727114873835,1.19076811908159,"B4GALNT3","beta-1,4-N-acetyl-galactosaminyltransferase 3",TRUE
+"1553727_at",0.990810941805126,0.956671740104104,0.0549487875115002,-5.93821296431114,0.0451555118705116,"B4GALNT3","beta-1,4-N-acetyl-galactosaminyltransferase 3",TRUE
+"238060_s_at",0.813080573937853,0.362945486740324,0.928910714955356,-5.52792697520334,0.767801496432955,"B4GALNT4","beta-1,4-N-acetyl-galactosaminyltransferase 4",TRUE
+"238080_at",0.874581551143405,0.521021861615784,-0.652136110812308,-5.7346406298161,-0.723799424605239,"B4GALNT4","beta-1,4-N-acetyl-galactosaminyltransferase 4",TRUE
+"229403_at",0.585036027492332,0.0652590762021446,1.93964277630657,-4.25662160435976,1.02101052974364,"B4GALT1","beta-1,4-galactosyltransferase 1",TRUE
+"238987_at",0.897699110987203,0.585101451443082,0.554038486859974,-5.79127108626315,0.262508012238935,"B4GALT1","beta-1,4-galactosyltransferase 1",TRUE
+"216627_s_at",0.925511384407886,0.677763849930911,0.421065261605095,-5.85369616399001,0.439406982147307,"B4GALT1","beta-1,4-galactosyltransferase 1",TRUE
+"201883_s_at",0.957417243518445,0.807207364873704,0.246967433741196,-5.91001966810953,0.0941664606775809,"B4GALT1","beta-1,4-galactosyltransferase 1",TRUE
+"211631_x_at",0.962511279328391,0.828965589982526,0.218596154759801,-5.91643628348455,0.103802450077492,"B4GALT1","beta-1,4-galactosyltransferase 1",TRUE
+"201882_x_at",0.993615552413264,0.970159646538134,0.0378329964932476,-5.93898635398619,0.0203685346742786,"B4GALT1","beta-1,4-galactosyltransferase 1",TRUE
+"209413_at",0.780080760647675,0.301431481119404,1.05805148698786,-5.40866028468881,0.298497504500361,"B4GALT2","beta-1,4-galactosyltransferase 2",TRUE
+"210243_s_at",0.69794616906853,0.168908202690522,-1.42215054008191,-4.99986012677138,-0.597496365796742,"B4GALT3","beta-1,4-galactosyltransferase 3",TRUE
+"238312_s_at",0.782471668844017,0.304747756331371,1.05064231097895,-5.41588183169774,0.70079442492709,"B4GALT3","beta-1,4-galactosyltransferase 3",TRUE
+"212876_at",0.606900628956089,0.080292199774972,1.83288677536847,-4.42379976144177,0.920738081848558,"B4GALT4","beta-1,4-galactosyltransferase 4",TRUE
+"210540_s_at",0.702809964629668,0.174616647258668,1.4025201631844,-5.02448618984634,0.867003863121138,"B4GALT4","beta-1,4-galactosyltransferase 4",TRUE
+"221484_at",0.623667408398064,0.0950958849878306,1.74356743647876,-4.55843733707954,0.957675382649002,"B4GALT5","beta-1,4-galactosyltransferase 5",TRUE
+"221485_at",0.847579833261406,0.446446303028719,0.775148687537994,-5.6511912556587,0.459458693710852,"B4GALT5","beta-1,4-galactosyltransferase 5",TRUE
+"206232_s_at",0.819018525257656,0.373792399172392,0.907722266310573,-5.54613908692834,0.986333958628938,"B4GALT6","beta-1,4-galactosyltransferase 6",TRUE
+"231342_at",0.919354071504066,0.656833633820051,-0.450350271792126,-5.84137948618241,-0.146972170131954,"B4GALT6","beta-1,4-galactosyltransferase 6",TRUE
+"206233_at",0.959451355429682,0.816812407515813,-0.23441895052938,-5.91295365566938,-0.195691463492873,"B4GALT6","beta-1,4-galactosyltransferase 6",TRUE
+"235333_at",0.99739139970986,0.986821937106212,-0.0167044120757579,-5.93954757284182,-0.0126717423441853,"B4GALT6","beta-1,4-galactosyltransferase 6",TRUE
+"222191_s_at",0.975242094553739,0.879656790475396,0.153162084444738,-5.9282641047842,0.0443222169052575,"B4GALT7","beta-1,4-galactosyltransferase 7",TRUE
+"53076_at",0.979976490833035,0.904522657096682,-0.121330815550372,-5.9325158858059,-0.0368055379311869,"B4GALT7","beta-1,4-galactosyltransferase 7",TRUE
+"203188_at",0.766550448794594,0.267415261076959,-1.13766147887344,-5.32821653335224,-0.471229001708068,"B4GAT1","beta-1,4-glucuronyltransferase 1",TRUE
+"228203_at",0.7995040428866,0.335022136881874,0.98549283298199,-5.4774065984859,0.409353022413365,"B4GAT1","beta-1,4-glucuronyltransferase 1",TRUE
+"205662_at",0.42510292927997,0.0180062190576965,2.55473615181363,-3.17983915740568,0.982947052921265,"B9D1","B9 domain containing 1",TRUE
+"210534_s_at",0.457032025390949,0.0225871447537922,2.45115353028064,-3.37299961299923,1.30792819313753,"B9D1","B9 domain containing 1",TRUE
+"210535_at",0.856148000488586,0.469593459289478,0.735762073030041,-5.67939851274444,0.53139887690227,"B9D1","B9 domain containing 1",TRUE
+"219766_at",0.951893068371814,0.779567211323252,-0.283312954622441,-5.90066420052674,-0.243953882855068,"B9D2","B9 protein domain 2",TRUE
+"218899_s_at",0.57460012602512,0.0605682508588878,1.9774021524231,-4.19592807374247,1.43845902217239,"BAALC","brain and acute leukemia, cytoplasmic",TRUE
+"222780_s_at",0.662575055303091,0.130442759858847,1.57062084533787,-4.80468552940622,0.879679961915253,"BAALC","brain and acute leukemia, cytoplasmic",TRUE
+"232326_at",0.89748872632674,0.584167403055207,0.555427433896954,-5.79053150648486,0.297343781435623,"BAALC-AS2","BAALC antisense RNA 2",TRUE
+"1554228_a_at",0.933609099853387,0.706107386797501,0.38199078961822,-5.86886153407418,0.237169218375327,"BAALC-AS2","BAALC antisense RNA 2",TRUE
+"206913_at",0.804347638345604,0.343041211356978,-0.968925096732652,-5.49248201120837,-0.654812824116914,"BAAT","bile acid-CoA:amino acid N-acyltransferase",TRUE
+"221711_s_at",0.942856731597582,0.743941191403043,-0.330749410331619,-5.88654113526865,-0.114416533806663,"BABAM1","BRISC and BRCA1 A complex member 1",TRUE
+"222463_s_at",0.433660982257499,0.0195631863538731,-2.51702156502829,-3.25065003276478,-1.8722010086753,"BACE1","beta-secretase 1",TRUE
+"222462_s_at",0.622917527985155,0.0937176935005443,-1.751356817163,-4.54689203965037,-0.721600773762992,"BACE1","beta-secretase 1",TRUE
+"224335_s_at",0.895690630367785,0.576098312605326,-0.567472816312884,-5.78404230103477,-0.213030120806465,"BACE1","beta-secretase 1",TRUE
+"217904_s_at",0.906476756086155,0.613475835927728,-0.512349918509778,-5.81263069874494,-0.380928453774162,"BACE1","beta-secretase 1",TRUE
+"222446_s_at",0.68033297785336,0.147659445148419,1.5002740479425,-4.89909848146809,1.38552693388202,"BACE2","beta-site APP-cleaving enzyme 2",TRUE
+"217867_x_at",0.705639263092475,0.177703649081304,1.39211711010033,-5.03742222480844,1.46769921843858,"BACE2","beta-site APP-cleaving enzyme 2",TRUE
+"227051_at",0.791707425459848,0.322402667637681,1.0121281318976,-5.45268371169392,1.60822345426401,"BACE2","beta-site APP-cleaving enzyme 2",TRUE
+"204194_at",0.636147339487472,0.107355194105748,1.6782190700176,-4.65377983679364,0.89920953834981,"BACH1","BTB domain and CNC homolog 1",TRUE
+"234315_at",0.719780078143386,0.19564063541452,1.33435304182408,-5.10779135226316,0.809249111440033,"BACH1","BTB domain and CNC homolog 1",TRUE
+"234938_at",0.958794064221941,0.813592432426307,0.23862129055521,-5.91198803885013,0.0888722017056685,"BACH1","BTB domain and CNC homolog 1",TRUE
+"227173_s_at",0.936992192746977,0.719021953577996,0.36438921496972,-5.87521760093436,0.246303801031289,"BACH2","BTB domain and CNC homolog 2",TRUE
+"221234_s_at",0.993007207436969,0.966726797209968,0.042187883623115,-5.93881663443478,0.0209861470786148,"BACH2","BTB domain and CNC homolog 2",TRUE
+"209364_at",0.830635993561085,0.4037880725341,-0.85115614707486,-5.59285149068443,-0.280648050338154,"BAD","BCL2 associated agonist of cell death",TRUE
+"1861_at",0.849317522308637,0.450235373874596,-0.768618556903391,-5.65596404179626,-0.202174670623661,"BAD","BCL2 associated agonist of cell death",TRUE
+"232660_at",0.932830928398943,0.70335034571025,-0.385764205744408,-5.86746043943721,-0.240981810669445,"BAD","BCL2 associated agonist of cell death",TRUE
+"229720_at",0.75466931720949,0.248151508830752,1.18608751116851,-5.27676917533022,0.589164484477738,"BAG1","BCL2 associated athanogene 1",TRUE
+"202387_at",0.979588787486838,0.902066374186104,-0.124468894136399,-5.93214046847942,-0.0463526507605501,"BAG1","BCL2 associated athanogene 1",TRUE
+"211475_s_at",0.992342196993659,0.964264403143651,-0.0453121684848179,-5.93868349580709,-0.0188626334943347,"BAG1","BCL2 associated athanogene 1",TRUE
+"209406_at",0.39149295959037,0.0132720301239944,2.69179666596137,-2.91815054048137,3.34849436587304,"BAG2","BCL2 associated athanogene 2",TRUE
+"230750_at",0.516444287133032,0.0363127709976732,2.22840415389992,-3.77324508122469,1.66897386148439,"BAG2","BCL2 associated athanogene 2",TRUE
+"230879_at",0.536559328842429,0.0434732121624302,2.14156762908422,-3.92310479968914,0.834302620943569,"BAG2","BCL2 associated athanogene 2",TRUE
+"217911_s_at",0.934867348047609,0.710875354276714,0.375478392180517,-5.87124768238232,0.220601356306258,"BAG3","BCL2 associated athanogene 3",TRUE
+"228189_at",0.810403302881961,0.354457879929021,-0.945787645118124,-5.51314436497801,-0.516487830373675,"BAG4","BCL2 associated athanogene 4",TRUE
+"219624_at",0.901788521024914,0.599490007789794,-0.532778900975658,-5.80236670416054,-0.288610314577695,"BAG4","BCL2 associated athanogene 4",TRUE
+"222909_s_at",0.948882130664959,0.767342206851114,-0.29951044542608,-5.89608495215925,-0.249362726288512,"BAG4","BCL2 associated athanogene 4",TRUE
+"202985_s_at",0.687734660055697,0.156875782008012,-1.46533989840539,-4.94469550344047,-0.523687093087769,"BAG5","BCL2 associated athanogene 5",TRUE
+"202984_s_at",0.773754791548713,0.285375249426011,-1.09477185185678,-5.37220024331956,-0.458775495012629,"BAG5","BCL2 associated athanogene 5",TRUE
+"230427_s_at",0.784789297644843,0.309075853806195,-1.04105805410874,-5.42515571077406,-0.460472834513165,"BAG5","BCL2 associated athanogene 5",TRUE
+"201255_x_at",0.689848451630875,0.158938903203782,1.45774887905771,-4.95448858272774,0.396830473619946,"BAG6","BCL2 associated athanogene 6",TRUE
+"213318_s_at",0.761311110432845,0.26044580529373,1.15487388554122,-5.31014579939848,0.32595575432863,"BAG6","BCL2 associated athanogene 6",TRUE
+"210208_x_at",0.804120194657066,0.342790339513543,0.969439366213034,-5.49201757024855,0.246251949979209,"BAG6","BCL2 associated athanogene 6",TRUE
+"230513_at",0.896428361916712,0.580834658959343,0.560392324826194,-5.78787313305728,0.339865505008319,"BAG6","BCL2 associated athanogene 6",TRUE
+"207712_at",0.485571841560871,0.0281310843244017,2.34922843572111,-3.55883695977966,2.57226591399763,"BAGE","B melanoma antigen",TRUE
+"1555369_at",0.714362239193388,0.189320692197754,1.35421005222944,-5.08388201702491,1.38033158811054,"BAGE","B melanoma antigen",TRUE
+"1555605_x_at",0.872540606821582,0.515880201004278,0.660280355879252,-5.72954057319633,0.494101136950714,"BAGE","B melanoma antigen",TRUE
+"1555603_at",0.968980656821882,0.85348742269082,0.18683858843554,-5.92269504947304,0.095358480533859,"BAGE","B melanoma antigen",TRUE
+"1555409_a_at",0.640337040581689,0.111155717460646,1.65924786962555,-4.68094348329008,1.14030925948103,"BAGE2///BAGE3///BAGE5///KMT2C","B melanoma antigen family member 2///B melanoma antigen family member 3///B melanoma antigen family member 5///lysine methyltransferase 2C",TRUE
+"1555408_at",0.643082025527735,0.113551213246408,1.64756958426302,-4.69754780355022,0.826549296978532,"BAGE2///BAGE4","B melanoma antigen family member 2///B melanoma antigen family member 4",TRUE
+"236604_at",0.667291317524503,0.133848813521559,1.55612048987028,-4.82442647383209,1.2179025722726,"BAHCC1","BAH domain and coiled-coil containing 1",TRUE
+"219218_at",0.697871681043328,0.168829402606907,1.42242521251989,-4.9995135588062,1.43990029746568,"BAHCC1","BAH domain and coiled-coil containing 1",TRUE
+"1559075_s_at",0.84042015032092,0.429548076830692,0.804691835835505,-5.62912343597178,0.290249521295928,"BAHCC1","BAH domain and coiled-coil containing 1",TRUE
+"203051_at",0.909748582642183,0.62458935344163,-0.496272942704128,-5.82043298422558,-0.169330260995569,"BAHD1","bromo adjacent homology domain containing 1",TRUE
+"209502_s_at",0.597879550155311,0.0752176266051528,1.86680882576077,-4.37140066023885,0.79748328632353,"BAIAP2","BAI1 associated protein 2",TRUE
+"207832_at",0.663789119801086,0.131670952056548,1.56535639530333,-4.81186925386735,1.22952050478554,"BAIAP2","BAI1 associated protein 2",TRUE
+"205293_x_at",0.718706241731185,0.194709914355039,1.33724541153085,-5.10432715690718,0.95332017445476,"BAIAP2","BAI1 associated protein 2",TRUE
+"205294_at",0.891420607788025,0.560984932680428,0.590265984507854,-5.77139397631805,0.199974819011938,"BAIAP2","BAI1 associated protein 2",TRUE
+"1566555_at",0.464342841802699,0.0238817022615307,2.42543235729809,-3.4203052380857,1.54487681214564,"BAIAP2-AS1","BAIAP2 antisense RNA 1 (head to head)",TRUE
+"1558148_x_at",0.888777794593349,0.55571835685888,0.598282854666976,-5.76683078108791,0.299856293589015,"BAIAP2-AS1","BAIAP2 antisense RNA 1 (head to head)",TRUE
+"1558147_a_at",0.917102138198416,0.649571928546154,0.460603531907372,-5.83687526831633,0.194674745073531,"BAIAP2-AS1","BAIAP2 antisense RNA 1 (head to head)",TRUE
+"1566557_at",0.95168059103032,0.778489518680037,-0.284737670199599,-5.90027154229854,-0.162553560979653,"BAIAP2-AS1","BAIAP2 antisense RNA 1 (head to head)",TRUE
+"1566558_x_at",0.966051687342135,0.84160903468643,0.202195360659569,-5.91979049127967,0.093527285874047,"BAIAP2-AS1","BAIAP2 antisense RNA 1 (head to head)",TRUE
+"227371_at",0.623667408398064,0.0949494323351423,1.74439056267282,-4.55721911091424,0.933590030887325,"BAIAP2L1","BAI1 associated protein 2 like 1",TRUE
+"227372_s_at",0.664998991885118,0.13258626448175,1.56145944102959,-4.81717471975885,0.814702492433449,"BAIAP2L1","BAI1 associated protein 2 like 1",TRUE
+"222675_s_at",0.877223961993707,0.526538122520335,0.643447537478024,-5.7400145602827,0.561121831450256,"BAIAP2L1","BAI1 associated protein 2 like 1",TRUE
+"228876_at",0.713633547141264,0.188566185608589,1.35661536482357,-5.08096577128009,0.872991440789005,"BAIAP2L2","BAI1 associated protein 2 like 2",TRUE
+"221178_at",0.945534735950946,0.754525478363782,0.316580311758965,-5.89098605547158,0.232657400869726,"BAIAP2L2","BAI1 associated protein 2 like 2",TRUE
+"216356_x_at",0.925511384407886,0.677676737168218,-0.421186357259113,-5.85364690820627,-0.294047000763914,"BAIAP3","BAI1 associated protein 3",TRUE
+"204874_x_at",0.995025131654789,0.976676531220136,0.0295677163530621,-5.93925767485135,0.0161640470679307,"BAIAP3","BAI1 associated protein 3",TRUE
+"203728_at",0.686108994812404,0.154798960074826,-1.47306346037743,-4.93468915769722,-0.417630014959752,"BAK1","BCL2 antagonist/killer 1",TRUE
+"203304_at",0.769258076576208,0.276591675981979,-1.1154939268838,-5.35113651995526,-1.02046065472334,"BAMBI","BMP and activin membrane bound inhibitor",TRUE
+"239239_at",0.877510999184545,0.527670944561036,-0.641669420350331,-5.74110580058819,-0.477848919591622,"BANCR","BRAF-activated non-protein coding RNA",TRUE
+"210125_s_at",0.952293443370532,0.7816747803793,-0.280528463586796,-5.90142597620991,-0.0771884579696227,"BANF1","barrier to autointegration factor 1",TRUE
+"232766_at",0.522667179791589,0.0383692136488704,-2.20197992723798,-3.819234483245,-1.38438300354706,"BANF2","barrier to autointegration factor 2",TRUE
+"219667_s_at",0.831517565727606,0.40624594816124,-0.846643195474515,-5.5964578866332,-1.02565483254269,"BANK1","B-cell scaffold protein with ankyrin repeats 1",TRUE
+"222915_s_at",0.93919895813272,0.727884165435952,0.352378531170938,-5.87938484979626,0.15001729827399,"BANK1","B-cell scaffold protein with ankyrin repeats 1",TRUE
+"1558662_s_at",0.943512938262733,0.74739169928137,0.326122794935336,-5.88801370739705,0.314942276970688,"BANK1","B-cell scaffold protein with ankyrin repeats 1",TRUE
+"228928_x_at",0.722160153958635,0.19835428301709,-1.32598098653373,-5.11778301405028,-0.427979173937059,"BANP","BTG3 associated nuclear protein",TRUE
+"219966_x_at",0.906476756086155,0.613915610181218,-0.511711156437786,-5.81294532323511,-0.144230060104523,"BANP","BTG3 associated nuclear protein",TRUE
+"233186_s_at",0.971826767527606,0.865076304705121,0.171900311880347,-5.92530114329005,0.0567247325448115,"BANP","BTG3 associated nuclear protein",TRUE
+"201419_at",0.562894650172193,0.0554419427257817,-2.02175192176428,-4.12363507584067,-0.536330698196334,"BAP1","BRCA1 associated protein 1",TRUE
+"1555735_a_at",0.627021415091472,0.0976772319366074,-1.72923425136397,-4.57958204841342,-0.473176587601092,"BAP1","BRCA1 associated protein 1",TRUE
+"242655_at",0.695812999227098,0.16569156109319,-1.43344730207485,-4.98556119811137,-0.442849576401458,"BARD1","BRCA1 associated RING domain 1",TRUE
+"227545_at",0.75959865506602,0.257309794609833,-1.1627300056539,-5.30181869617805,-0.343882538008742,"BARD1","BRCA1 associated RING domain 1",TRUE
+"205345_at",0.828535730541669,0.398678484673203,-0.860594583442058,-5.58525128902647,-0.254891902027552,"BARD1","BRCA1 associated RING domain 1",TRUE
+"224092_at",0.971216837324271,0.863020586565022,0.174547150708179,-5.92485515609767,0.102916527926046,"BARHL1","BarH like homeobox 1",TRUE
+"219845_at",0.827820249318594,0.3968389343327,0.864011632346461,-5.58248051000609,0.80990325717916,"BARX1","BARX homeobox 1",TRUE
+"1561506_at",0.77766827327863,0.296684929790162,1.06875782406792,-5.39814471843616,0.579831026332876,"BARX1-AS1","BARX1 antisense RNA 1 (head to head)",TRUE
+"210419_at",0.766390367856479,0.266806640337356,-1.13915132786142,-5.3266618377944,-0.746441502176487,"BARX2","BARX homeobox 2",TRUE
+"202391_at",0.757950630724418,0.254395602606678,1.17009434536935,-5.29396792825431,2.14967286695359,"BASP1","brain abundant membrane attached signal protein 1",TRUE
+"228589_at",0.917106560962976,0.64969891953871,0.460423797180152,-5.83695508071977,0.33937834206146,"BASP1","brain abundant membrane attached signal protein 1",TRUE
+"205965_at",0.700061364939874,0.171533778295897,-1.41305676587138,-5.01130315752784,-1.44746437197373,"BATF","basic leucine zipper ATF-like transcription factor",TRUE
+"228439_at",0.788523943581388,0.314760586532488,-1.02861255651825,-5.43708392508692,-0.469319383736904,"BATF2","basic leucine zipper ATF-like transcription factor 2",TRUE
+"220358_at",0.992093589969215,0.963292201938247,-0.0465458225995218,-5.93862830694394,-0.0364592690535881,"BATF3","basic leucine zipper ATF-like transcription factor 3",TRUE
+"211833_s_at",0.820536502908875,0.380531697898744,-0.894762098707983,-5.55708748378414,-0.410747608115438,"BAX","BCL2 associated X, apoptosis regulator",TRUE
+"208478_s_at",0.942502815705589,0.741732362458757,-0.333714983455748,-5.88558644949284,-0.150444487345748,"BAX","BCL2 associated X, apoptosis regulator",TRUE
+"217986_s_at",0.662015916975184,0.129876855691185,-1.57306034180341,-4.80135024236924,-0.616708938792694,"BAZ1A","bromodomain adjacent to zinc finger domain 1A",TRUE
+"217985_s_at",0.783844746433788,0.306615036370287,-1.04649561242127,-5.41990362192515,-0.440384915932212,"BAZ1A","bromodomain adjacent to zinc finger domain 1A",TRUE
+"211313_s_at",0.789378278298554,0.315767567034186,1.02642451304825,-5.43916765058105,0.848665017070299,"BAZ1B","bromodomain adjacent to zinc finger domain 1B",TRUE
+"208445_s_at",0.84233976083031,0.436029262204288,-0.793277676732411,-5.63774154200684,-0.23734556048964,"BAZ1B","bromodomain adjacent to zinc finger domain 1B",TRUE
+"213336_at",0.924029559540466,0.673181912569677,0.427443370806673,-5.85108292046145,0.333617255546588,"BAZ1B","bromodomain adjacent to zinc finger domain 1B",TRUE
+"229658_at",0.929972194057784,0.691046159323245,0.4026749396955,-5.86101471132522,0.129641991965276,"BAZ1B","bromodomain adjacent to zinc finger domain 1B",TRUE
+"201355_s_at",0.657015752622694,0.125501143900147,1.59222714859244,-4.77500450269239,0.805506110327801,"BAZ2A","bromodomain adjacent to zinc finger domain 2A",TRUE
+"201353_s_at",0.815201671543626,0.366173531805028,-0.922561465136885,-5.53342496450959,-0.350552799537482,"BAZ2A","bromodomain adjacent to zinc finger domain 2A",TRUE
+"201354_s_at",0.861763798017736,0.484027803566269,-0.711781368439027,-5.69588888843192,-0.284717006550819,"BAZ2A","bromodomain adjacent to zinc finger domain 2A",TRUE
+"215437_x_at",0.946264126508924,0.756578624423184,-0.313839514044158,-5.89182361682245,-0.180717148620489,"BAZ2A","bromodomain adjacent to zinc finger domain 2A",TRUE
+"203080_s_at",0.88440457468396,0.543611774443836,0.616863907765251,-5.75602601706792,0.253065891769042,"BAZ2B","bromodomain adjacent to zinc finger domain 2B",TRUE
+"232885_at",0.722362743674536,0.198895875618659,1.32432081740745,-5.11975805863217,1.21176813931743,"BBIP1","BBSome interacting protein 1",TRUE
+"213224_s_at",0.822173415758858,0.386083707253889,-0.884197991099017,-5.56590394114593,-0.581857556743921,"BBIP1","BBSome interacting protein 1",TRUE
+"232910_at",0.859122424227944,0.475974178902681,-0.725108901305471,-5.68678829570613,-0.433059929093531,"BBIP1","BBSome interacting protein 1",TRUE
+"228993_s_at",0.868313695469383,0.50274052754968,-0.681300780667169,-5.71609710229194,-0.627894117651959,"BBIP1","BBSome interacting protein 1",TRUE
+"213220_at",0.897949253801113,0.586285059274955,0.552280021257727,-5.79220484666385,0.409941497765868,"BBIP1","BBSome interacting protein 1",TRUE
+"239933_x_at",0.642592458809121,0.112660145933307,1.65188916732631,-4.69141661097197,1.00756781750351,"BBOF1","basal body orientation factor 1",TRUE
+"220173_at",0.901781358899845,0.598796130267614,-0.533798369498677,-5.80184426723526,-0.155781740775357,"BBOF1","basal body orientation factor 1",TRUE
+"205363_at",0.878788356961452,0.532080531037068,-0.634767682956536,-5.7453139327429,-0.688470499183423,"BBOX1","gamma-butyrobetaine hydroxylase 1",TRUE
+"243018_at",0.937462538530338,0.72252782404117,-0.359631384601521,-5.87688488410946,-0.144406436582559,"BBOX1-AS1","BBOX1 antisense RNA 1",TRUE
+"229142_s_at",0.843753336849204,0.439219321392567,0.78769801876302,-5.64191223300801,0.515629252095742,"BBS1","Bardet-Biedl syndrome 1",TRUE
+"222643_s_at",0.962966982691316,0.832039395430146,0.214603412540129,-5.91727683313576,0.107147556845371,"BBS1","Bardet-Biedl syndrome 1",TRUE
+"218471_s_at",0.982909728377256,0.91707854127723,0.105308544897996,-5.93428344751191,0.0414677331408217,"BBS1","Bardet-Biedl syndrome 1",TRUE
+"219487_at",0.769258076576208,0.276475260109795,-1.1157717635833,-5.35085172231201,-0.487315747409842,"BBS10","Bardet-Biedl syndrome 10",TRUE
+"229603_at",0.948429371744093,0.765121620618492,0.302461275090704,-5.8952235365442,0.12598078143003,"BBS12","Bardet-Biedl syndrome 12",TRUE
+"223227_at",0.975449397348071,0.882704328547317,-0.14925282837384,-5.9288392852577,-0.0580331347441714,"BBS2","Bardet-Biedl syndrome 2",TRUE
+"212745_s_at",0.478602853563251,0.0266974848905078,-2.3736723541412,-3.514669119563,-1.88610689895648,"BBS4","Bardet-Biedl syndrome 4",TRUE
+"212744_at",0.599805419912392,0.0762992673754202,-1.85941480956849,-4.38288031701294,-0.815914436250928,"BBS4","Bardet-Biedl syndrome 4",TRUE
+"230697_at",0.808257777979515,0.350465306776996,-0.953820855376933,-5.50602229170393,-0.635090516427717,"BBS5","Bardet-Biedl syndrome 5",TRUE
+"219688_at",0.548218374816971,0.0483394748055349,2.08966228191167,-4.01089136376766,0.763032779016896,"BBS7","Bardet-Biedl syndrome 7",TRUE
+"235007_at",0.973433731874338,0.871418019164806,0.163742867399343,-5.92663290850037,0.0923055683232477,"BBS7","Bardet-Biedl syndrome 7",TRUE
+"1555555_at",0.686108994812404,0.154855391141267,-1.47285248932775,-4.93496304882071,-0.731671160856422,"BBS9","Bardet-Biedl syndrome 9",TRUE
+"216239_at",0.722362743674536,0.198907541865214,1.32428509519398,-5.11980053317714,0.892891291217384,"BBS9","Bardet-Biedl syndrome 9",TRUE
+"37547_at",0.857316604145187,0.472623873613536,0.730691979088299,-5.68292824828481,0.617871244923738,"BBS9","Bardet-Biedl syndrome 9",TRUE
+"209958_s_at",0.871451481476429,0.512550874149673,0.665577927218648,-5.72619057646924,0.558094690498325,"BBS9","Bardet-Biedl syndrome 9",TRUE
+"37549_g_at",0.921603564091029,0.665582216846874,-0.43806226770479,-5.84664653447784,-0.144200738272517,"BBS9","Bardet-Biedl syndrome 9",TRUE
+"232008_s_at",0.820536502908875,0.38080095810689,0.89424744112124,-5.55751924650582,0.419372611541025,"BBX","BBX, HMG-box containing",TRUE
+"213015_at",0.83176405048326,0.406612796407271,0.845971115325742,-5.59699343021647,0.411808482614642,"BBX","BBX, HMG-box containing",TRUE
+"1557239_at",0.837067957688307,0.419305864153718,0.822950111387375,-5.61509757196239,0.681526670032887,"BBX","BBX, HMG-box containing",TRUE
+"223134_at",0.859947009633611,0.47844145651153,0.721012047908136,-5.68960289055528,0.327633472618844,"BBX","BBX, HMG-box containing",TRUE
+"223135_s_at",0.8920930097751,0.564186508491334,0.585411533757315,-5.77412819098884,0.248153666383953,"BBX","BBX, HMG-box containing",TRUE
+"213016_at",0.955234687900581,0.795310473926099,0.26256673111622,-5.90616039469446,0.127776020407246,"BBX","BBX, HMG-box containing",TRUE
+"226331_at",0.981372324306002,0.911779728261049,0.112066544649782,-5.93356834920811,0.0472764610098046,"BBX","BBX, HMG-box containing",TRUE
+"203009_at",0.859122424227944,0.476001748461584,-0.725063054150123,-5.6868198772068,-0.37975684503585,"BCAM","basal cell adhesion molecule (Lutheran blood group)",TRUE
+"40093_at",0.96287357728432,0.831529011272976,-0.215266131021148,-5.91713838569393,-0.176288454110518,"BCAM","basal cell adhesion molecule (Lutheran blood group)",TRUE
+"242843_at",0.622060264811154,0.0922936052701982,1.75950941749543,-4.53476772288824,0.540358132956577,"BCAN","brevican",TRUE
+"91920_at",0.817055852876968,0.369479791723383,0.91609694502673,-5.5389870858116,0.259805310643694,"BCAN","brevican",TRUE
+"219107_at",0.939356991756184,0.728404478808842,0.351675022982456,-5.87962466288043,0.206464246307291,"BCAN","brevican",TRUE
+"221623_at",0.979612118310508,0.903066007387205,0.123191637962817,-5.93229442538892,0.084180253040492,"BCAN","brevican",TRUE
+"230150_at",0.557589172116298,0.0523915231897785,2.04990626110287,-4.07718966061445,1.52729519456615,"BCAP29","B-cell receptor-associated protein 29",TRUE
+"225674_at",0.639705117673934,0.110248759930107,1.66372480250129,-4.67455441827413,0.621945470831724,"BCAP29","B-cell receptor-associated protein 29",TRUE
+"236970_s_at",0.687734660055697,0.157002414414287,1.4648716477268,-4.94530078119981,0.641863213415497,"BCAP29","B-cell receptor-associated protein 29",TRUE
+"225677_at",0.73957587762701,0.22779774954564,1.24041339529212,-5.21683573252078,0.556563558669088,"BCAP29","B-cell receptor-associated protein 29",TRUE
+"241640_at",0.774230543658252,0.286910808480051,-1.09119678804692,-5.37579872126862,-0.519685644327348,"BCAP29","B-cell receptor-associated protein 29",TRUE
+"205084_at",0.893780254958927,0.569256695353173,0.577752651104247,-5.77839753866468,0.217622235596302,"BCAP29","B-cell receptor-associated protein 29",TRUE
+"200837_at",0.866602763987519,0.497673392525222,-0.689489567248866,-5.7107509814348,-0.263685705435194,"BCAP31","B-cell receptor-associated protein 31",TRUE
+"223116_at",0.959203345279235,0.815272105767356,0.236428631479725,-5.91249399866645,0.132814118445197,"BCAR1","BCAR1, Cas family scaffolding protein",TRUE
+"232442_at",0.989586772349659,0.949584138938798,-0.0639491772832063,-5.93769183368577,-0.0545484155859208,"BCAR1","BCAR1, Cas family scaffolding protein",TRUE
+"204032_at",0.81035488031479,0.35417249038948,0.946359823879484,-5.51263890957979,0.710602204105887,"BCAR3","breast cancer anti-estrogen resistance 3",TRUE
+"230854_at",0.922486281852799,0.66884061853075,0.433503172633056,-5.84856433968047,0.403094951677414,"BCAR4","breast cancer anti-estrogen resistance 4 (non-protein coding)",TRUE
+"204378_at",0.708675738217514,0.180648844870591,-1.38232512733175,-5.04952556672187,-1.22216374170915,"BCAS1","breast carcinoma amplified sequence 1",TRUE
+"203053_at",0.783844746433788,0.306417313697357,-1.04693384981677,-5.41947926087546,-0.574578311890335,"BCAS2","breast carcinoma amplified sequence 2",TRUE
+"220488_s_at",0.855405088766616,0.468340223022378,-0.737864470201154,-5.67792805644515,-0.854151502890159,"BCAS3","BCAS3, microtubule associated cell migration factor",TRUE
+"239278_at",0.676294804179428,0.14290876469108,-1.51898127031775,-4.8743271370519,-1.11387010207512,"BCAS4","breast carcinoma amplified sequence 4",TRUE
+"1569005_at",0.69170225097251,0.161314959344316,1.44910454915018,-4.96559019622877,0.512291187118253,"BCAS4","breast carcinoma amplified sequence 4",TRUE
+"220588_at",0.708713388831643,0.180765985708213,-1.38193829519533,-5.05000225478972,-0.946101654091299,"BCAS4","breast carcinoma amplified sequence 4",TRUE
+"228787_s_at",0.809020025635536,0.352180807135828,-0.950361656888875,-5.50909590916431,-0.684030781405964,"BCAS4","breast carcinoma amplified sequence 4",TRUE
+"231584_s_at",0.913123070637484,0.635204696029298,0.481039521211893,-5.82760170609191,0.255307358739711,"BCAS4","breast carcinoma amplified sequence 4",TRUE
+"225285_at",0.163850812837738,0.00131474561336643,3.67543317983107,-0.897811931388371,5.09749666776781,"BCAT1","branched chain amino acid transaminase 1",TRUE
+"214390_s_at",0.194325783329824,0.00207519573198405,3.48636835406416,-1.29969451201674,4.72171435102248,"BCAT1","branched chain amino acid transaminase 1",TRUE
+"226517_at",0.227168192678334,0.00284931357896484,3.35399966042945,-1.57830889124043,5.85183546113824,"BCAT1","branched chain amino acid transaminase 1",TRUE
+"214452_at",0.245363000968222,0.00330163100438518,3.29212621862587,-1.70759848084225,4.1695156592124,"BCAT1","branched chain amino acid transaminase 1",TRUE
+"215654_at",0.852546356114556,0.458589635726183,-0.754337157629563,-5.66626912253623,-0.421727749363343,"BCAT2","branched chain amino acid transaminase 2",TRUE
+"203576_at",0.863940083411105,0.490316612496508,-0.701463540821826,-5.70282390663118,-0.288469855196167,"BCAT2","branched chain amino acid transaminase 2",TRUE
+"227896_at",0.560923390313819,0.0545343372058467,2.0299814519002,-4.11010293452609,1.10125972986098,"BCCIP","BRCA2 and CDKN1A interacting protein",TRUE
+"227322_s_at",0.81326404604492,0.363116632684931,0.928573142344507,-5.52822016182246,0.366753154736623,"BCCIP","BRCA2 and CDKN1A interacting protein",TRUE
+"218264_at",0.991367768700244,0.959932121079242,0.0508101085154588,-5.9384261241037,0.0307181863031349,"BCCIP","BRCA2 and CDKN1A interacting protein",TRUE
+"234979_at",0.595936234743389,0.0724107072373205,-1.88643876428449,-4.34076815801919,-0.668288752748295,"BCDIN3D","BCDIN3 domain containing RNA methyltransferase",TRUE
+"244543_s_at",0.642592458809121,0.112812611811086,1.65114803078414,-4.69246944833626,0.883714960769172,"BCDIN3D-AS1","BCDIN3D antisense RNA 1",TRUE
+"244542_at",0.653678932109172,0.123012391997646,1.60337804283495,-4.75956265085712,0.898297081468313,"BCDIN3D-AS1","BCDIN3D antisense RNA 1",TRUE
+"205433_at",0.658025827253199,0.12655037171591,1.58758120021161,-4.78141347398045,2.2805145757018,"BCHE","butyrylcholinesterase",TRUE
+"202331_at",0.599805419912392,0.076331890475545,-1.85919322329601,-4.38322384489367,-0.906177855338909,"BCKDHA","branched chain keto acid dehydrogenase E1, alpha polypeptide",TRUE
+"210653_s_at",0.786808592179943,0.312507277325645,1.03352659929875,-5.43238957732087,0.493426378311204,"BCKDHB","branched chain keto acid dehydrogenase E1 subunit beta",TRUE
+"213321_at",0.839519981963042,0.426435493937661,0.810211457967325,-5.62491443870945,0.588228558654637,"BCKDHB","branched chain keto acid dehydrogenase E1 subunit beta",TRUE
+"202030_at",0.525602259313086,0.0394141611922022,-2.18904228699111,-3.84162920497376,-0.627554233064034,"BCKDK","branched chain ketoacid dehydrogenase kinase",TRUE
+"1557257_at",0.64513208805899,0.116365663510521,1.63411083852501,-4.71657216956956,0.755444591155517,"BCL10","B-cell CLL/lymphoma 10",TRUE
+"1557258_a_at",0.748760747870936,0.241895480027751,1.20241595797054,-5.25900001217907,0.330433979109806,"BCL10","B-cell CLL/lymphoma 10",TRUE
+"205263_at",0.886023097762234,0.548633978739809,0.609129670591759,-5.76056216214535,0.205587546514778,"BCL10","B-cell CLL/lymphoma 10",TRUE
+"222891_s_at",0.540483367247649,0.0449914289253237,2.12483512596053,-3.95155369611277,2.49166562580091,"BCL11A","B-cell CLL/lymphoma 11A",TRUE
+"219498_s_at",0.62110896023334,0.0916483978316967,1.76323866663415,-4.52920787265422,1.72580400260752,"BCL11A","B-cell CLL/lymphoma 11A",TRUE
+"219497_s_at",0.740270784944871,0.22875470138726,1.23777856806478,-5.2197960271118,1.2268529850592,"BCL11A","B-cell CLL/lymphoma 11A",TRUE
+"210347_s_at",0.773887727472977,0.28547022981834,1.09455031747825,-5.37242353312895,0.540128863871336,"BCL11A","B-cell CLL/lymphoma 11A",TRUE
+"224310_s_at",0.528176582660474,0.0407677522930682,-2.1727380031366,-3.86973562008846,-1.74434981267658,"BCL11B","B-cell CLL/lymphoma 11B",TRUE
+"219528_s_at",0.850536169066796,0.453323468414938,-0.763321077213776,-5.65980787935078,-0.712715676290615,"BCL11B","B-cell CLL/lymphoma 11B",TRUE
+"222895_s_at",0.932091525948902,0.699725123227201,0.390734559118096,-5.86559419776127,0.559709949988966,"BCL11B","B-cell CLL/lymphoma 11B",TRUE
+"203684_s_at",0.69805586360447,0.169078258833361,-1.42155812747936,-5.0006074164764,-1.37528286382169,"BCL2","BCL2, apoptosis regulator",TRUE
+"207005_s_at",0.752913428584105,0.246116320323304,-1.19136521170474,-5.27104893942908,-0.748065626903442,"BCL2","BCL2, apoptosis regulator",TRUE
+"203685_at",0.783686116003587,0.306279011006212,-1.04724050635661,-5.41918221931488,-1.28316038100574,"BCL2","BCL2, apoptosis regulator",TRUE
+"207004_at",0.904832003218088,0.609998663030653,-0.517408071696518,-5.8101257778677,-0.144336128900341,"BCL2","BCL2, apoptosis regulator",TRUE
+"205681_at",0.981587171772385,0.912498541083643,-0.111149478871906,-5.93366799304239,-0.089415251427134,"BCL2A1","BCL2 related protein A1",TRUE
+"231228_at",0.752235383514782,0.245512438420431,1.19293749839571,-5.26934053962745,0.616972410168826,"BCL2L1","BCL2 like 1",TRUE
+"206665_s_at",0.860944723152316,0.480948050832029,0.716862526124541,-5.69243820788126,0.395001254201098,"BCL2L1","BCL2 like 1",TRUE
+"212312_at",0.8920930097751,0.563681452038663,0.586176389738988,-5.77369884394406,0.210357970953426,"BCL2L1","BCL2 like 1",TRUE
+"215037_s_at",0.905384410285554,0.611128216370882,0.51576344653516,-5.81094286786937,0.25011686540453,"BCL2L1","BCL2 like 1",TRUE
+"236491_at",0.308861881799719,0.00639670600731287,3.01092456767072,-2.2858355523999,2.06790512178491,"BCL2L10","BCL2 like 10",TRUE
+"221320_at",0.675447258877226,0.141769481575503,1.52354315178256,-4.8682493291602,0.974887441346358,"BCL2L10","BCL2 like 10",TRUE
+"225606_at",0.487700365372434,0.0288383224736915,-2.33758923898913,-3.5797767073375,-1.2279424729471,"BCL2L11","BCL2 like 11",TRUE
+"1558143_a_at",0.696440263939453,0.166432345471109,-1.43083017834687,-4.98888207813219,-0.719681525472369,"BCL2L11","BCL2 like 11",TRUE
+"222343_at",0.81836001261482,0.371564560643648,0.912040474200193,-5.54245889121489,0.334900057217594,"BCL2L11","BCL2 like 11",TRUE
+"1553096_s_at",0.821903997044289,0.384998608792805,-0.886254814899394,-5.56419498873272,-0.342303906327317,"BCL2L11","BCL2 like 11",TRUE
+"208536_s_at",0.942502815705589,0.741638523323908,-0.3338410392719,-5.88554568244117,-0.238054587320299,"BCL2L11","BCL2 like 11",TRUE
+"1555372_at",0.974138689437749,0.874244666988169,0.160110602063956,-5.9272051281321,0.0680865711692462,"BCL2L11","BCL2 like 11",TRUE
+"1553088_a_at",0.986342822130003,0.934740596570279,-0.0828171283633948,-5.9363434242379,-0.0199696438073325,"BCL2L11","BCL2 like 11",TRUE
+"233110_s_at",0.996140682541913,0.98065983993107,-0.0245168146215223,-5.93939072390868,-0.0110087971766788,"BCL2L12","BCL2 like 12",TRUE
+"1560977_a_at",0.774230543658252,0.289520080908799,1.08515344476446,-5.38185779324064,0.405129155026381,"BCL2L13","BCL2 like 13",TRUE
+"226798_at",0.859064198633089,0.475737492167616,0.725502566623703,-5.68651704392365,0.224722477194292,"BCL2L13","BCL2 like 13",TRUE
+"223664_x_at",0.869644002139811,0.507089536940454,-0.674309651096886,-5.72061298780653,-0.179267221112699,"BCL2L13","BCL2 like 13",TRUE
+"224035_s_at",0.912252515563073,0.632527302552534,0.484870667992091,-5.82581935898558,0.14694634722278,"BCL2L13","BCL2 like 13",TRUE
+"217955_at",0.925091998149497,0.675885926295009,0.423677190266944,-5.85263067100871,0.138174527032296,"BCL2L13","BCL2 like 13",TRUE
+"221241_s_at",0.76198358665095,0.261380926705781,1.15254483759619,-5.31260494949425,1.02935556861831,"BCL2L14","BCL2 like 14",TRUE
+"233464_at",0.831875452294783,0.407610216670913,-0.844145755516177,-5.59844595603517,-0.732514440909375,"BCL2L14","BCL2 like 14",TRUE
+"1552841_s_at",0.859122424227944,0.475908679921231,0.725217829925955,-5.68671325335658,0.478409188369633,"BCL2L14","BCL2 like 14",TRUE
+"1569719_at",0.871451481476429,0.512381211935981,-0.665848402961916,-5.72601884888506,-0.722514512090305,"BCL2L14","BCL2 like 14",TRUE
+"234191_at",0.923749415271371,0.672533774737753,0.428347036884448,-5.85070954753974,0.252079803654552,"BCL2L14","BCL2 like 14",TRUE
+"234533_at",0.951343155145488,0.777517492230016,0.286023210835903,-5.89991556409881,0.185358463427923,"BCL2L14","BCL2 like 14",TRUE
+"242013_at",0.847797601020174,0.447104179742718,0.774012486787307,-5.65202442832979,0.428318117368694,"BCL2L15","BCL2 like 15",TRUE
+"236083_at",0.886916043359667,0.550500725172339,-0.606264411144168,-5.76222862600404,-0.461414608232265,"BCL2L15","BCL2 like 15",TRUE
+"236979_at",0.930827859648584,0.693716820709469,0.398994418612419,-5.86244077193868,0.237234770585901,"BCL2L15","BCL2 like 15",TRUE
+"1555140_a_at",0.986421906591669,0.936352450109241,0.0807669001651009,-5.93650672503987,0.0241826846980393,"BCL2L2","BCL2 like 2",TRUE
+"209311_at",0.989524702314661,0.948822511852235,0.0649166595580933,-5.93763112103846,0.0178919333064158,"BCL2L2","BCL2 like 2",TRUE
+"201545_s_at",0.813442508625161,0.363451326137648,-0.927913291917297,-5.52879296824396,-0.317908361101797,"BCL2L2-PABPN1///PABPN1","BCL2L2-PABPN1 readthrough///poly(A) binding protein nuclear 1",TRUE
+"201544_x_at",0.975196332002567,0.879487459470558,-0.153379366374039,-5.92823170019122,-0.0385511811913979,"BCL2L2-PABPN1///PABPN1///BCL2L2","BCL2L2-PABPN1 readthrough///poly(A) binding protein nuclear 1///BCL2 like 2",TRUE
+"215990_s_at",0.492341486607851,0.0295720623501957,-2.32578809378165,-3.60094707325804,-0.996219909983832,"BCL6","B-cell CLL/lymphoma 6",TRUE
+"203140_at",0.72050514215489,0.196555271667634,-1.33152114039523,-5.11117701635861,-0.814616088054795,"BCL6","B-cell CLL/lymphoma 6",TRUE
+"228758_at",0.925271562705333,0.676415053831094,0.422940945524346,-5.85293166532277,0.288170714738428,"BCL6","B-cell CLL/lymphoma 6",TRUE
+"242148_at",0.90466378569832,0.608802685162202,0.51915098740223,-5.8092570881223,0.328060816653411,"BCL6B","B-cell CLL/lymphoma 6B",TRUE
+"1554625_at",0.932633693661011,0.702546602267991,0.386865318735337,-5.86704902992954,0.11978481515597,"BCL6B","B-cell CLL/lymphoma 6B",TRUE
+"228311_at",0.95715439915087,0.805900370643078,0.24867804448584,-5.90960792754295,0.112050066990694,"BCL6B","B-cell CLL/lymphoma 6B",TRUE
+"243825_at",0.991957147109766,0.962913236208957,-0.0470267230747618,-5.93860639186259,-0.0161531652410334,"BCL6B","B-cell CLL/lymphoma 6B",TRUE
+"203795_s_at",0.795428381027683,0.327569555138899,-1.00113676192852,-5.46295841056594,-0.577889896204541,"BCL7A","BCL tumor suppressor 7A",TRUE
+"203796_s_at",0.832792886465252,0.409842037992694,-0.840071620047745,-5.60167737530094,-0.494066918393597,"BCL7A","BCL tumor suppressor 7A",TRUE
+"202518_at",0.899269421995144,0.589677317190122,-0.547249915930317,-5.79485995831028,-0.157744420176932,"BCL7B","BCL tumor suppressor 7B",TRUE
+"219072_at",0.877948371309952,0.529527869847972,-0.638759218171957,-5.74288554549282,-0.298991033464928,"BCL7C","BCL tumor suppressor 7C",TRUE
+"204129_at",0.79782885150643,0.331399599592686,-0.993066631527556,-5.4704375231801,-0.430943567768368,"BCL9","B-cell CLL/lymphoma 9",TRUE
+"228065_at",0.904951417527118,0.610484281373027,0.516700836481192,-5.81047746030542,0.219568788356515,"BCL9L","B-cell CLL/lymphoma 9-like",TRUE
+"227616_at",0.952644489493803,0.783139852751004,0.278594165352571,-5.9019507624875,0.107834141816143,"BCL9L","B-cell CLL/lymphoma 9-like",TRUE
+"239897_at",0.812302873476553,0.35988865572142,0.934958125964117,-5.5226581158135,0.321637542194728,"BCLAF1","BCL2 associated transcription factor 1",TRUE
+"201101_s_at",0.95168059103032,0.778372570300031,0.284892312750423,-5.90022880451717,0.0885306759644546,"BCLAF1","BCL2 associated transcription factor 1",TRUE
+"229454_at",0.955816406528307,0.798865924853057,-0.257897995962353,-5.90734006362412,-0.145231342715372,"BCLAF1","BCL2 associated transcription factor 1",TRUE
+"201083_s_at",0.97649060127871,0.888369803350787,0.141991666643369,-5.92986826096515,0.0413959259333332,"BCLAF1","BCL2 associated transcription factor 1",TRUE
+"214499_s_at",0.98693003519805,0.939745601975124,-0.0764520633628568,-5.93683703762925,-0.0212703957874769,"BCLAF1","BCL2 associated transcription factor 1",TRUE
+"201084_s_at",0.990623482682449,0.952689572084117,-0.0600050342628044,-5.93792991138528,-0.0148907622256704,"BCLAF1","BCL2 associated transcription factor 1",TRUE
+"220087_at",0.885029460971826,0.545481278591932,0.613980448412457,-5.75772362385248,0.758315331783323,"BCO1","beta-carotene oxygenase 1",TRUE
+"232449_at",0.515810181619652,0.0360802372097646,2.23147724841661,-3.76787502514407,1.77605767824348,"BCO2","beta-carotene oxygenase 2",TRUE
+"219433_at",0.12699262910615,0.00075995303313249,-3.90078560417471,-0.41446766707798,-3.31188004987668,"BCOR","BCL6 corepressor",TRUE
+"223566_s_at",0.238811487311851,0.00316364769350321,-3.31007902618753,-1.6701517775597,-2.27148334072548,"BCOR","BCL6 corepressor",TRUE
+"223916_s_at",0.399719600134805,0.0142186230170378,-2.66105999664528,-2.97740640429761,-2.30364221933824,"BCOR","BCL6 corepressor",TRUE
+"223915_at",0.571677937624457,0.0593672076399829,-1.98748531265983,-4.17958645776971,-1.74471962017729,"BCOR","BCL6 corepressor",TRUE
+"233572_s_at",0.872668627020452,0.516546212077197,0.659222890365386,-5.73020620436197,0.161762930452489,"BCORL1","BCL6 corepressor-like 1",TRUE
+"219444_at",0.879419229950485,0.533667497918295,-0.632291407675802,-5.74681310052729,-0.218376463735355,"BCORL1","BCL6 corepressor-like 1",TRUE
+"233574_at",0.949108933724268,0.770412288770482,0.29543522240021,-5.8972608375616,0.124947234391809,"BCORL1","BCL6 corepressor-like 1",TRUE
+"234711_s_at",0.955396260969248,0.795640071350833,0.262133680775047,-5.90627070000037,0.0833286219711695,"BCORL1","BCL6 corepressor-like 1",TRUE
+"1562313_at",0.685248518609124,0.153844088997293,1.47664280669503,-4.93003747519362,0.737824647527808,"BCORP1","BCL6 corepressor pseudogene 1",TRUE
+"217223_s_at",0.800342373547779,0.336136477801146,-0.98317438749213,-5.47953022427843,-0.421495082427109,"BCR","BCR, RhoGEF and GTPase activating protein",TRUE
+"226602_s_at",0.931670437657228,0.698475925735158,-0.392449586009617,-5.86494478537984,-0.144324484383535,"BCR","BCR, RhoGEF and GTPase activating protein",TRUE
+"202315_s_at",0.986421906591669,0.936548782564269,0.0805171957248603,-5.93652633455952,0.0313178910497864,"BCR","BCR, RhoGEF and GTPase activating protein",TRUE
+"1553592_x_at",0.937113154905832,0.720815014981852,0.361954780740741,-5.87607340123953,0.210582317695675,"BCRP3","breakpoint cluster region pseudogene 3",TRUE
+"1553591_at",0.959203345279235,0.815035176354483,-0.236737849009055,-5.9124229275579,-0.133740138019279,"BCRP3","breakpoint cluster region pseudogene 3",TRUE
+"207618_s_at",0.851319596585235,0.455248281671797,-0.760030162548773,-5.66218310477255,-0.216625718776946,"BCS1L","BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone",TRUE
+"1570336_at",0.919354071504066,0.656835413280562,0.450347765303683,-5.84138057511981,0.282330199053003,"BDH1","3-hydroxybutyrate dehydrogenase, type 1",TRUE
+"211715_s_at",0.957571530817866,0.808989708768518,0.24463589155475,-5.91057631555463,0.170361909751097,"BDH1","3-hydroxybutyrate dehydrogenase, type 1",TRUE
+"235155_at",0.174167700159084,0.0015411359404624,-3.60979444220212,-1.03778798334276,-2.45831540290455,"BDH2","3-hydroxybutyrate dehydrogenase, type 2",TRUE
+"218285_s_at",0.96351240321323,0.833782027212016,-0.212341396269033,-5.91774618624967,-0.103666488248111,"BDH2","3-hydroxybutyrate dehydrogenase, type 2",TRUE
+"207510_at",0.953190828780557,0.784902743362748,0.276268102649437,-5.90257706380057,0.11724782548951,"BDKRB1","bradykinin receptor B1",TRUE
+"205870_at",0.84396230746828,0.440249638249709,-0.78590123716877,-5.64324939325673,-0.929495841425471,"BDKRB2","bradykinin receptor B2",TRUE
+"206382_s_at",0.682125064335234,0.149612120486607,1.49272723976756,-4.90902200643645,2.19420533997753,"BDNF","brain derived neurotrophic factor",TRUE
+"239367_at",0.968066640321622,0.850104365292865,-0.191207471957945,-5.92189198023628,-0.231800112424819,"BDNF","brain derived neurotrophic factor",TRUE
+"1567361_at",0.676306030659334,0.143061979564809,1.51837005002361,-4.87514036396685,2.19412023779657,"BDNF-AS","BDNF antisense RNA",TRUE
+"1567359_at",0.796466121438385,0.32924663881017,0.997595049546047,-5.46624751255323,1.30260194425351,"BDNF-AS","BDNF antisense RNA",TRUE
+"226290_at",0.80008362094922,0.335601584104682,-0.984286601074815,-5.47851203855472,-0.305859059784849,"BDP1","B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB",TRUE
+"224227_s_at",0.854763246850622,0.466620611718547,0.740754673080153,-5.6759000974687,0.437474281358451,"BDP1","B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB",TRUE
+"231939_s_at",0.957017346544368,0.805504747291942,-0.24919599070716,-5.90948270171324,-0.0813675295429528,"BDP1","B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB",TRUE
+"214068_at",0.592007267652348,0.0691018867798913,1.91045250548965,-4.30298971373391,1.21939554690933,"BEAN1","brain expressed, associated with NEDD4, 1",TRUE
+"208945_s_at",0.827866702343255,0.397202480943193,-0.863335519880141,-5.58302955934952,-0.255268588025107,"BECN1","beclin 1",TRUE
+"208946_s_at",0.870517518639056,0.509463484455058,-0.670507691583704,-5.72305013221721,-0.195771794391685,"BECN1","beclin 1",TRUE
+"1561652_at",0.903488560782255,0.604619953645144,0.525259415657289,-5.80619011322656,0.329066172799475,"BECN1","beclin 1",TRUE
+"220795_s_at",0.789595899448337,0.316901112616923,-1.02396731045975,-5.44150292680132,-0.655105404223797,"BEGAIN","brain enriched guanylate kinase associated",TRUE
+"1553842_at",0.552420073963858,0.0501480438051851,2.07156289225982,-4.04117703949174,1.58720639442277,"BEND2","BEN domain containing 2",TRUE
+"227920_at",0.755049574909504,0.248729933103999,1.18459343876966,-5.27838450425953,0.357373162655096,"BEND3","BEN domain containing 3",TRUE
+"230896_at",0.411110107932987,0.0161731178915861,2.60326452959762,-3.08794647588981,2.00592899260486,"BEND4","BEN domain containing 4",TRUE
+"238101_at",0.75017710842651,0.243090844835774,-1.19927172755543,-5.26243809780844,-0.660688455316076,"BEND4","BEN domain containing 4",TRUE
+"1558476_at",0.75536453281804,0.249387383477133,1.1828983914209,-5.28021496822293,0.709045507952926,"BEND5","BEN domain containing 5",TRUE
+"219670_at",0.96200396340887,0.827238216563623,-0.22084153101376,-5.91595681271357,-0.21417244741762,"BEND5","BEN domain containing 5",TRUE
+"1568820_a_at",0.516444287133032,0.0363659900404604,2.22770334759143,-3.77446907441325,1.99753103196277,"BEND6","BEN domain containing 6",TRUE
+"231175_at",0.630603891142543,0.101880468248273,1.70657268154145,-4.61274740834738,1.49768049099656,"BEND6","BEN domain containing 6",TRUE
+"227341_at",0.802073451619221,0.339768142898084,0.975654977530245,-5.48638641965488,1.40847720707062,"BEND7","BEN domain containing 7",TRUE
+"1553327_a_at",0.974884920935236,0.877329003519211,-0.156149717210981,-5.92781452322201,-0.0920230287420294,"BEND7","BEN domain containing 7",TRUE
+"1561509_at",0.996261754016157,0.981770865207643,-0.0231081384349526,-5.93942339917302,-0.015014962157494,"BEND7","BEN domain containing 7",TRUE
+"1554442_at",0.780655891246127,0.302242555219358,-1.05623406542632,-5.41043589788385,-0.461804139969493,"BEST1","bestrophin 1",TRUE
+"207671_s_at",0.910860516303107,0.628014845337428,0.491344383342775,-5.82277621843501,0.373727726085108,"BEST1","bestrophin 1",TRUE
+"1554443_s_at",0.932269331146744,0.701365890471575,0.388483755054521,-5.8664422347426,0.179304545122474,"BEST1","bestrophin 1",TRUE
+"207432_at",0.878788356961452,0.532150161327665,-0.634658949335998,-5.74537987974165,-0.546439144199662,"BEST2","bestrophin 2",TRUE
+"224520_s_at",0.843095426822889,0.437345010233734,-0.790973300200013,-5.6394673796945,-0.632240374609534,"BEST3","bestrophin 3",TRUE
+"1555492_a_at",0.940964444369914,0.735576610325372,-0.341995920836798,-5.88287599750752,-0.276867109033414,"BEST3","bestrophin 3",TRUE
+"237003_at",0.943988850936011,0.749483302659967,0.323321804561396,-5.88889523646106,0.149544288081576,"BEST3","bestrophin 3",TRUE
+"1552296_at",0.818519306419264,0.371765705282297,0.911649893415918,-5.54279242691249,0.725572405776413,"BEST4","bestrophin 4",TRUE
+"202710_at",0.967360241632547,0.847189948789964,0.194974204705062,-5.92118474837582,0.0587710524371925,"BET1","Bet1 golgi vesicular membrane trafficking protein",TRUE
+"223023_at",0.712975827977365,0.187397707927449,-1.36035540329405,-5.07642269434603,-0.959091919285205,"BET1L","Bet1 golgi vesicular membrane trafficking protein like",TRUE
+"220470_at",0.801086839730802,0.3371296163422,-0.981112561153965,-5.48141496849241,-0.774366054217535,"BET1L","Bet1 golgi vesicular membrane trafficking protein like",TRUE
+"218332_at",0.736094223891156,0.221304801341165,1.25851737868766,-5.1963492305151,0.855294711052221,"BEX1","brain expressed X-linked 1",TRUE
+"224367_at",0.952613441433926,0.782709133250345,-0.279162720494357,-5.90179688415498,-0.274280213384811,"BEX2","brain expressed X-linked 2",TRUE
+"217963_s_at",0.93613089056626,0.714489365133699,0.370553153432332,-5.87302541154523,0.585077271035045,"BEX3","brain expressed X-linked 3",TRUE
+"215440_s_at",0.963737076458538,0.834394093663172,0.211547175290732,-5.91790980719927,0.330593328449027,"BEX4","brain expressed X-linked 4",TRUE
+"229963_at",0.965584868976477,0.839016944626682,-0.205552991704677,-5.91912500195548,-0.235508762580452,"BEX5","brain expressed X-linked 5",TRUE
+"218056_at",0.828607509614823,0.3990162631276,0.859968248451362,-5.5857580564531,0.184402285039003,"BFAR","bifunctional apoptosis regulator",TRUE
+"206746_at",0.766550448794594,0.267367436010964,-1.13777846007921,-5.32809452536353,-0.915171897693177,"BFSP1","beaded filament structural protein 1",TRUE
+"207399_at",0.993213867476782,0.96763711166125,0.0410329875590507,-5.93886344287461,0.038829341803778,"BFSP2","beaded filament structural protein 2",TRUE
+"236825_at",0.7717895132349,0.28152590649827,-1.10379538007409,-5.36307106161288,-0.558169579386253,"BFSP2-AS1","BFSP2 antisense RNA 1",TRUE
+"1553936_a_at",0.838999550222784,0.424586989828862,-0.813501344817129,-5.62239288757455,-0.491129835713949,"BFSP2-AS1","BFSP2 antisense RNA 1",TRUE
+"1553935_at",0.91876780831279,0.654883824695099,-0.453098473244453,-5.84018196201188,-0.428893367724116,"BFSP2-AS1","BFSP2 antisense RNA 1",TRUE
+"237739_at",0.966593471043185,0.844603389186232,0.198319616802807,-5.92054509728665,0.0798233078791366,"BGLT3","beta globin locus transcript 3 (non-protein coding)",TRUE
+"201261_x_at",0.79943091106207,0.334115105325711,0.987383883196552,-5.47567108332958,1.05865868488824,"BGN","biglycan",TRUE
+"213905_x_at",0.86880806912978,0.505158324571391,-0.677409932644485,-5.71861587460811,-0.948203388366243,"BGN","biglycan",TRUE
+"201262_s_at",0.983567332578112,0.919861784061554,-0.101760884821231,-5.93464106507824,-0.103279232064414,"BGN","biglycan",TRUE
+"235965_at",0.62986301194198,0.101169766271138,1.71034775868462,-4.60724527191875,0.857330255955217,"BHLHA15","basic helix-loop-helix family member a15",TRUE
+"213709_at",0.897949253801113,0.586425954348216,0.552070813215955,-5.7923157460961,0.344907125403321,"BHLHB9","basic helix-loop-helix domain containing, class B, 9",TRUE
+"228636_at",0.576307892687871,0.0611987860072387,1.97217927691729,-4.2043706074583,1.09748905776086,"BHLHE22","basic helix-loop-helix family member e22",TRUE
+"244323_at",0.804966190665093,0.344069480289232,0.966819897722482,-5.49438088754552,0.71159743800103,"BHLHE22","basic helix-loop-helix family member e22",TRUE
+"234045_x_at",0.990810941805126,0.956166228393259,-0.0555905627504563,-5.93817841644893,-0.0374168666189774,"BHLHE23","basic helix-loop-helix family member e23",TRUE
+"201170_s_at",0.985709215004606,0.930981294371752,0.0876002746920361,-5.93594654279946,0.07606848143657,"BHLHE40","basic helix-loop-helix family member e40",TRUE
+"201169_s_at",0.991957147109766,0.962907551275248,-0.0470339372363378,-5.93860606139198,-0.0381594410700359,"BHLHE40","basic helix-loop-helix family member e40",TRUE
+"231243_s_at",0.0786674128142594,0.000261865004704073,4.33603542562289,0.52514795511835,2.75194401060768,"BHLHE41","basic helix-loop-helix family member e41",TRUE
+"223185_s_at",0.170374697680568,0.0014134875474539,3.64553567048516,-0.96162295201075,4.74450144543292,"BHLHE41","basic helix-loop-helix family member e41",TRUE
+"221530_s_at",0.308621629697291,0.0063611918669261,3.01331921415491,-2.28098544163381,4.57547139420473,"BHLHE41","basic helix-loop-helix family member e41",TRUE
+"231242_at",0.820536502908875,0.380466741078212,0.894886291431617,-5.55698326010444,0.641157805902877,"BHLHE41","basic helix-loop-helix family member e41",TRUE
+"206119_at",0.96350209729653,0.833468308212739,0.212748533990309,-5.91766207333527,0.123183325515344,"BHMT","betaine--homocysteine S-methyltransferase",TRUE
+"219902_at",0.274882222151803,0.00438860688765249,3.17187412990102,-1.95689223647982,2.35401552459574,"BHMT2","betaine--homocysteine S-methyltransferase 2",TRUE
+"230309_at",0.744573608322482,0.235693871913906,1.21891888053451,-5.24082673853233,0.776763974116234,"BHMT2","betaine--homocysteine S-methyltransferase 2",TRUE
+"242169_at",0.831487912516861,0.406060971690689,-0.846982226373513,-5.59618758105935,-0.592438413708123,"BHMT2","betaine--homocysteine S-methyltransferase 2",TRUE
+"213429_at",0.787929163003677,0.313818560728771,1.03066391803407,-5.43512672872528,1.50985137910755,"BICC1","BicC family RNA binding protein 1",TRUE
+"220580_at",0.937113154905832,0.720314232642654,0.362634466545304,-5.87583503463889,0.114988725617719,"BICC1","BicC family RNA binding protein 1",TRUE
+"214806_at",0.461321138453616,0.0231664343172714,2.43947918352066,-3.39450418225636,1.71375127717888,"BICD1","BICD cargo adaptor 1",TRUE
+"1556051_a_at",0.620223198657182,0.0901006152092144,1.77227750813188,-4.51569621828129,0.979300239753909,"BICD1","BICD cargo adaptor 1",TRUE
+"231964_at",0.656693876264681,0.124851503060042,1.59511997370628,-4.77100654987879,1.01542606773091,"BICD1","BICD cargo adaptor 1",TRUE
+"242228_at",0.680708651141727,0.148525518541698,1.49691681089555,-4.9035179737226,0.75432633363624,"BICD1","BICD cargo adaptor 1",TRUE
+"204741_at",0.767011398042819,0.268255869407094,1.13560783622802,-5.33035662085579,0.707287814405484,"BICD1","BICD cargo adaptor 1",TRUE
+"1554020_at",0.787303934962758,0.313139161626597,1.03214607083794,-5.43371042365461,0.767990181403608,"BICD1","BICD cargo adaptor 1",TRUE
+"1553021_s_at",0.552420073963858,0.0498345725271001,2.07465761980176,-4.0360107317083,1.37875891257534,"BICD2","BICD cargo adaptor 2",TRUE
+"209203_s_at",0.644427363911159,0.114906673448009,1.64105316777219,-4.70677390983453,0.826450790746978,"BICD2","BICD cargo adaptor 2",TRUE
+"213154_s_at",0.713607328718737,0.188350569012164,1.35730412824342,-5.08012990539498,0.545900236456051,"BICD2","BICD cargo adaptor 2",TRUE
+"212702_s_at",0.774641130415354,0.291037543721111,1.08165686066867,-5.38534977176546,0.457859350265668,"BICD2","BICD cargo adaptor 2",TRUE
+"228320_x_at",0.89739147209919,0.583965087989338,-0.555728425589541,-5.79037099892586,-0.433925321514115,"BICDL1","BICD family like cargo adaptor 1",TRUE
+"215015_at",0.942671206410999,0.742737430833815,-0.332365202124115,-5.88602202040643,-0.157255294282695,"BICDL1","BICD family like cargo adaptor 1",TRUE
+"235095_at",0.997128956162635,0.985420555799463,0.0184809935570594,-5.93951712710748,0.0115515512658408,"BICDL2","BICD family like cargo adaptor 2",TRUE
+"211725_s_at",0.813065886130395,0.362871762682145,0.929056162980518,-5.52780062130919,0.504162208683624,"BID","BH3 interacting domain death agonist",TRUE
+"227143_s_at",0.893600768892136,0.568637417927381,0.578686236749759,-5.77788003584492,0.228741460070195,"BID","BH3 interacting domain death agonist",TRUE
+"204493_at",0.929829824527542,0.690369704170541,0.403608080444776,-5.860651106559,0.198345898486314,"BID","BH3 interacting domain death agonist",TRUE
+"205780_at",0.697412165374288,0.167851576150024,1.4258421928057,-4.99519759590406,1.68057284912854,"BIK","BCL2 interacting killer",TRUE
+"214643_x_at",0.718619138804591,0.194313037916545,1.33848206748878,-5.10284408994074,1.4903283582225,"BIN1","bridging integrator 1",TRUE
+"202931_x_at",0.742608345161152,0.232939872907854,1.22635280074657,-5.23257035695522,1.92935969631895,"BIN1","bridging integrator 1",TRUE
+"214439_x_at",0.76858139690485,0.271776263426988,1.12705829322689,-5.33922935618098,1.49941431182867,"BIN1","bridging integrator 1",TRUE
+"210201_x_at",0.860085676417428,0.479324066935053,0.719549494522204,-5.69060401169683,0.946830738588799,"BIN1","bridging integrator 1",TRUE
+"210202_s_at",0.876590919968167,0.525295236978169,0.645400818585886,-5.73881247701313,0.972098610938053,"BIN1","bridging integrator 1",TRUE
+"219191_s_at",0.99186228645105,0.962469858968259,-0.0475893749980878,-5.93858046540094,-0.0176617110808386,"BIN2","bridging integrator 2",TRUE
+"222199_s_at",0.740610299769501,0.23052506142262,1.23292616323709,-5.22523363339855,0.431734403007882,"BIN3","bridging integrator 3",TRUE
+"1557582_at",0.88330056907699,0.541256862657273,-0.620503562200099,-5.75387226337877,-0.203563295327376,"BIN3","bridging integrator 3",TRUE
+"207287_at",0.92494286004622,0.675229434218287,-0.424590985174736,-5.8522563743942,-0.265307038664046,"BIN3-IT1","BIN3 intronic transcript 1",TRUE
+"202076_at",0.713633547141264,0.188738762827187,1.35606453306751,-5.0816339917071,0.600799919480677,"BIRC2","baculoviral IAP repeat containing 2",TRUE
+"230499_at",0.319095917986488,0.00703538736580663,2.96990782547417,-2.36868909320619,1.50803978068819,"BIRC3","baculoviral IAP repeat containing 3",TRUE
+"210538_s_at",0.358427723880268,0.00996584712901168,2.81839191925987,-2.6708677722424,3.6101794916729,"BIRC3","baculoviral IAP repeat containing 3",TRUE
+"202094_at",0.219659214453661,0.00268773689016002,3.37844974584868,-1.52704419706946,1.0055192513085,"BIRC5","baculoviral IAP repeat containing 5",TRUE
+"1555826_at",0.779847351572723,0.301062373312187,-1.05887972085154,-5.40785019546599,-0.582310205827941,"BIRC5","baculoviral IAP repeat containing 5",TRUE
+"202095_s_at",0.807944276806637,0.349664503675751,0.955439553226406,-5.50458051108946,0.485583029333547,"BIRC5","baculoviral IAP repeat containing 5",TRUE
+"210334_x_at",0.90415231543826,0.606466388851107,0.522560415209753,-5.80754956052612,0.211700849078175,"BIRC5","baculoviral IAP repeat containing 5",TRUE
+"224635_s_at",0.697464915010884,0.168011637365774,1.42528177335567,-4.99590603961556,0.359163294056227,"BIRC6","baculoviral IAP repeat containing 6",TRUE
+"233093_s_at",0.739340500562926,0.226920401279313,1.24283646234188,-5.21410857388619,0.335343590643106,"BIRC6","baculoviral IAP repeat containing 6",TRUE
+"220451_s_at",0.757479140651,0.253660607353108,1.17196161481642,-5.2919704260365,0.393338120151281,"BIRC7","baculoviral IAP repeat containing 7",TRUE
+"1569289_at",0.775351898377291,0.292016936415029,1.07940706746003,-5.3875912831246,0.416365880196697,"BIVM","basic, immunoglobulin-like variable motif containing",TRUE
+"233255_s_at",0.830635993561085,0.403685508284433,0.8513448484692,-5.59270030600769,0.297611714609076,"BIVM","basic, immunoglobulin-like variable motif containing",TRUE
+"222761_at",0.870808709484996,0.510086089387665,0.669512211489668,-5.7236860786158,0.242334347342609,"BIVM","basic, immunoglobulin-like variable motif containing",TRUE
+"229478_x_at",0.930827859648584,0.693778925249496,-0.39890889731386,-5.86247375487602,-0.144619599595046,"BIVM","basic, immunoglobulin-like variable motif containing",TRUE
+"229589_x_at",0.970573392456845,0.860102786060478,-0.178306160550275,-5.92421009371542,-0.0783746094078079,"BIVM","basic, immunoglobulin-like variable motif containing",TRUE
+"232105_at",0.527546822913581,0.0400608837384869,2.18119012259674,-3.85518149484722,3.03456365295803,"BLACAT1","bladder cancer associated transcript 1 (non-protein coding)",TRUE
+"201032_at",0.975265330414469,0.880447577288472,0.152147463460616,-5.92841481473046,0.0703310587869073,"BLCAP","bladder cancer associated protein",TRUE
+"1555675_at",0.758189649141895,0.255000801066579,1.16855983631599,-5.2956073747253,1.07698458227832,"BLID","BH3-like motif containing, cell death inducer",TRUE
+"206255_at",0.776743077119289,0.294246744031475,-1.07430503679977,-5.39265908413319,-0.753877804884378,"BLK","BLK proto-oncogene, Src family tyrosine kinase",TRUE
+"210934_at",0.994279914572225,0.973839665391078,0.0331653822633592,-5.93914775347333,0.0210344155794102,"BLK","BLK proto-oncogene, Src family tyrosine kinase",TRUE
+"205733_at",0.838350471423215,0.423287229638609,0.815819961123687,-5.62061001469354,0.228814403064682,"BLM","Bloom syndrome RecQ like helicase",TRUE
+"202179_at",0.72050514215489,0.196560763214094,1.33150416862902,-5.11119728862751,1.69228645743256,"BLMH","bleomycin hydrolase",TRUE
+"207655_s_at",0.685132260208337,0.153542306069186,-1.47777779590533,-4.92856055070775,-1.8574910109031,"BLNK","B-cell linker",TRUE
+"202592_at",0.626725055602681,0.0972269212916679,-1.73171114851439,-4.57593732633566,-0.514948211501778,"BLOC1S1","biogenesis of lysosomal organelles complex 1 subunit 1",TRUE
+"210106_at",0.809225441530816,0.352427156959832,-0.949865845248525,-5.5095356167605,-0.346078626165436,"BLOC1S1-RDH5///RDH5","BLOC1S1-RDH5 readthrough///retinol dehydrogenase 5",TRUE
+"225049_at",0.930899509890345,0.694276239950193,-0.398224177282634,-5.86273757931265,-0.153394872723208,"BLOC1S2","biogenesis of lysosomal organelles complex 1 subunit 2",TRUE
+"228244_at",0.542277271596324,0.045427277230605,-2.1201255894381,-3.95953544130845,-0.765182803399094,"BLOC1S3","biogenesis of lysosomal organelles complex 1 subunit 3",TRUE
+"230576_at",0.621860007959892,0.0922183986198226,1.75994295187718,-4.53412182149009,1.09663990780849,"BLOC1S3","biogenesis of lysosomal organelles complex 1 subunit 3",TRUE
+"223431_at",0.0681210092794308,0.000173437961708729,-4.50411316075095,0.887968795543006,-1.87407085403173,"BLOC1S4","biogenesis of lysosomal organelles complex 1 subunit 4",TRUE
+"221253_s_at",0.645803111489595,0.117026249247166,1.63099157854652,-4.72096423394997,0.653124707546228,"BLOC1S5-TXNDC5///TXNDC5","BLOC1S5-TXNDC5 readthrough (NMD candidate)///thioredoxin domain containing 5",TRUE
+"222826_at",0.835952408568777,0.41625752313267,0.828438132364561,-5.6108240963012,0.319374982906867,"BLOC1S6","biogenesis of lysosomal organelles complex 1 subunit 6",TRUE
+"224883_at",0.86679822545543,0.498092615416206,-0.68881028804197,-5.71119677585905,-0.223844302333575,"BLOC1S6","biogenesis of lysosomal organelles complex 1 subunit 6",TRUE
+"224892_at",0.958931830316768,0.814027539607047,0.238053183802006,-5.91211957631398,0.0807456002951774,"BLOC1S6","biogenesis of lysosomal organelles complex 1 subunit 6",TRUE
+"229109_s_at",0.748184017928985,0.240539602319384,-1.20599656967413,-5.25507524078332,-1.26847927471598,"BLVRA","biliverdin reductase A",TRUE
+"203772_at",0.755049574909504,0.248662377036795,-1.18476780233812,-5.27819608115429,-0.801913130372486,"BLVRA","biliverdin reductase A",TRUE
+"211729_x_at",0.769258076576208,0.27616522984941,-1.11651209405672,-5.35009253674505,-0.667471361706159,"BLVRA","biliverdin reductase A",TRUE
+"203773_x_at",0.782096995485383,0.303837446525015,-1.05267038632176,-5.41390964389687,-0.733351044985522,"BLVRA","biliverdin reductase A",TRUE
+"203771_s_at",0.827768017240356,0.396591517048842,-0.8644719996262,-5.58210643163096,-0.568869266593017,"BLVRA","biliverdin reductase A",TRUE
+"202201_at",0.592605015502039,0.0697538741704919,-1.9056421449399,-4.31058407111742,-1.3880770931524,"BLVRB","biliverdin reductase B",TRUE
+"1558560_s_at",0.663819586595936,0.131916113700126,-1.56431042289842,-4.81329430253236,-1.02624020023002,"BLZF1","basic leucine zipper nuclear factor 1",TRUE
+"32088_at",0.705559553212919,0.177327361997266,-1.39337744016332,-5.03585926185482,-0.533156491793375,"BLZF1","basic leucine zipper nuclear factor 1",TRUE
+"203840_at",0.771159692311272,0.280234330680449,-1.10684308468373,-5.3599726312403,-0.450701012812759,"BLZF1","basic leucine zipper nuclear factor 1",TRUE
+"210462_at",0.821424121108148,0.382829125667889,-0.890378499579012,-5.56075766299947,-0.562400647261319,"BLZF1","basic leucine zipper nuclear factor 1",TRUE
+"226530_at",0.919437319385127,0.657740317752364,-0.449073526305572,-5.84193339539691,-0.226419987229326,"BMF","Bcl2 modifying factor",TRUE
+"207595_s_at",0.301965976738642,0.00578261391947485,3.05425529359809,-2.19785926322447,1.47957617690321,"BMP1","bone morphogenetic protein 1",TRUE
+"205574_x_at",0.305949355810268,0.0061002391734627,3.03131924191053,-2.24448350842729,1.61619368045683,"BMP1","bone morphogenetic protein 1",TRUE
+"202701_at",0.406385937583656,0.0154081033124997,2.62506082722999,-3.04639637969595,2.26834765295088,"BMP1","bone morphogenetic protein 1",TRUE
+"206725_x_at",0.420127229072219,0.0173998860302519,2.57025409454163,-3.15054851543754,1.22825987733515,"BMP1","bone morphogenetic protein 1",TRUE
+"1569001_at",0.809536981041684,0.352746392982845,0.949223689093799,-5.51010479663039,0.597765075684111,"BMP1","bone morphogenetic protein 1",TRUE
+"1569002_x_at",0.982243328340126,0.914753599777308,-0.108273091032086,-5.93397522193924,-0.0810978355739866,"BMP1","bone morphogenetic protein 1",TRUE
+"1570383_at",0.991059530537351,0.958413310568743,-0.0527379462750381,-5.93832890725128,-0.0355108546722391,"BMP1","bone morphogenetic protein 1",TRUE
+"208292_at",0.923110591956324,0.670380048728263,-0.431352480122357,-5.84946219914396,-0.166047043566025,"BMP10","bone morphogenetic protein 10",TRUE
+"221332_at",0.940756067985891,0.734849889834745,-0.342975130862327,-5.88255114659358,-0.104387570064207,"BMP15","bone morphogenetic protein 15",TRUE
+"205289_at",0.358427723880268,0.00984235203327666,2.82385979950106,-2.66007577824967,3.54064864423382,"BMP2","bone morphogenetic protein 2",TRUE
+"205290_s_at",0.570651551693487,0.0590429963956114,1.99023815214016,-4.17511524199737,1.85663915740498,"BMP2","bone morphogenetic protein 2",TRUE
+"37170_at",0.624331975868069,0.0958284960792649,1.73946606392244,-4.56450101781373,0.857925691563111,"BMP2K","BMP2 inducible kinase",TRUE
+"214716_at",0.803275622655718,0.34129201774649,0.972516187767835,-5.48923416944548,0.557900118456325,"BMP2K","BMP2 inducible kinase",TRUE
+"219546_at",0.886783047600321,0.550181556717984,-0.606753937999939,-5.76194444928968,-0.319518780793469,"BMP2K","BMP2 inducible kinase",TRUE
+"226853_at",0.964645095638491,0.836326816793506,0.209040173347846,-5.91842228051206,0.100448714803559,"BMP2K","BMP2 inducible kinase",TRUE
+"59644_at",0.9802233499944,0.907255249224282,-0.117841196336596,-5.93292211798819,-0.0513437797557152,"BMP2K","BMP2 inducible kinase",TRUE
+"232688_at",0.999016635322945,0.99689193348903,-0.0039395805851302,-5.93967592138837,-0.00240684753830545,"BMP2K","BMP2 inducible kinase",TRUE
+"208244_at",0.819018525257656,0.375122535890774,-0.905152182182781,-5.54832178794778,-0.893090059101265,"BMP3","bone morphogenetic protein 3",TRUE
+"211518_s_at",0.820291269575398,0.378952746658981,-0.897784893542704,-5.55454692550546,-1.38249796528013,"BMP4","bone morphogenetic protein 4",TRUE
+"205430_at",0.92051722798026,0.661617195927461,-0.443622816355909,-5.84428080635804,-0.593929788782305,"BMP5","bone morphogenetic protein 5",TRUE
+"205431_s_at",0.990918916504081,0.957444252786056,-0.0539680852766393,-5.93826498253303,-0.0361210780979278,"BMP5","bone morphogenetic protein 5",TRUE
+"206176_at",0.518537987260825,0.0371535276174405,2.21744042947902,-3.79236707579311,1.09669355531539,"BMP6","bone morphogenetic protein 6",TRUE
+"215042_at",0.64513208805899,0.115790903150452,-1.63683695120759,-4.71272839382411,-1.09071803419671,"BMP6","bone morphogenetic protein 6",TRUE
+"241141_at",0.893600768892136,0.568913564963263,0.57826986987371,-5.778110935217,0.447946729905162,"BMP6","bone morphogenetic protein 6",TRUE
+"211259_s_at",0.603702127972549,0.077859681928279,-1.84890723251837,-4.39913832962982,-2.28727221636407,"BMP7","bone morphogenetic protein 7",TRUE
+"211260_at",0.714590421965913,0.189959075800141,-1.35218082137861,-5.08633892957555,-1.08874714750866,"BMP7","bone morphogenetic protein 7",TRUE
+"209591_s_at",0.722080068577879,0.198273215721257,-1.32622979058376,-5.11748684107931,-2.11256857280913,"BMP7","bone morphogenetic protein 7",TRUE
+"209590_at",0.820293495506061,0.379053332140689,-0.897592082838806,-5.55470921312567,-1.27014335426194,"BMP7","bone morphogenetic protein 7",TRUE
+"220204_s_at",0.61591966964196,0.0869396466381599,-1.79116000364808,-4.4873069200568,-0.855820481256475,"BMP8A","bone morphogenetic protein 8a",TRUE
+"220203_at",0.708894565317004,0.181301506982696,-1.38017238162448,-5.05217696015901,-1.00051052658985,"BMP8A","bone morphogenetic protein 8a",TRUE
+"207866_at",0.994304286761558,0.973943021369873,-0.0330343003558459,-5.93915197977976,-0.0278320679194834,"BMP8A","bone morphogenetic protein 8a",TRUE
+"207865_s_at",0.617928982994696,0.0889343057555604,1.77917722487525,-4.50534816788488,0.818868549609512,"BMP8B","bone morphogenetic protein 8b",TRUE
+"221615_at",0.709158363400091,0.181839226131154,1.37840337832727,-5.05435315602831,0.47924186686973,"BMP8B","bone morphogenetic protein 8b",TRUE
+"235275_at",0.727891850116715,0.208143467127662,1.29650305760768,-5.15254065534504,0.899032004495612,"BMP8B","bone morphogenetic protein 8b",TRUE
+"241986_at",0.822812833182588,0.387951268433279,0.880666809006827,-5.56882930648511,0.778179684298388,"BMPER","BMP binding endothelial regulator",TRUE
+"213578_at",0.768285407497397,0.271414340555093,-1.12793349491788,-5.33832379095764,-0.432247388385214,"BMPR1A","bone morphogenetic protein receptor type 1A",TRUE
+"230979_at",0.789927874973432,0.319065964986481,1.01929159254443,-5.44593266822707,0.25686174732635,"BMPR1A","bone morphogenetic protein receptor type 1A",TRUE
+"204832_s_at",0.830635993561085,0.403307290895728,-0.852040971754481,-5.59214231245888,-0.289266854101706,"BMPR1A","bone morphogenetic protein receptor type 1A",TRUE
+"242731_x_at",0.930827859648584,0.693763163380763,-0.398930601969841,-5.86246538471635,-0.151728976077944,"BMPR1A","bone morphogenetic protein receptor type 1A",TRUE
+"227273_at",0.966593471043185,0.844821256529322,-0.198037742112642,-5.9205994106658,-0.0951478027960828,"BMPR1A","bone morphogenetic protein receptor type 1A",TRUE
+"242579_at",0.932018790587499,0.699324885181929,-0.391283916989698,-5.86538648288135,-0.203952857053892,"BMPR1B","bone morphogenetic protein receptor type 1B",TRUE
+"229975_at",0.957105919915331,0.805726799762582,-0.248905273215614,-5.90955302147605,-0.290150320029136,"BMPR1B","bone morphogenetic protein receptor type 1B",TRUE
+"210523_at",0.99783553534859,0.989955113845942,-0.0127325618180052,-5.93960451929346,-0.0097839939254829,"BMPR1B","bone morphogenetic protein receptor type 1B",TRUE
+"225144_at",0.719412173140763,0.195414149197804,-1.33505589090167,-5.10695012852476,-0.489296291461617,"BMPR2","bone morphogenetic protein receptor type 2",TRUE
+"1556075_at",0.803988341675731,0.342587266004359,0.969855840834579,-5.49164128375847,0.552979166892461,"BMPR2","bone morphogenetic protein receptor type 2",TRUE
+"209920_at",0.917724754910316,0.650833701014308,-0.458818384357137,-5.8376666211356,-0.144327732550202,"BMPR2","bone morphogenetic protein receptor type 2",TRUE
+"210214_s_at",0.928887766306469,0.68689884957993,0.408401736435494,-5.85877016732911,0.124034998088256,"BMPR2","bone morphogenetic protein receptor type 2",TRUE
+"238516_at",0.948015976270656,0.763816310701932,-0.304197116736475,-5.89471289361344,-0.126735723731495,"BMPR2","bone morphogenetic protein receptor type 2",TRUE
+"231873_at",0.965023008062487,0.837606435676514,0.20738109021127,-5.918758079713,0.072521404635113,"BMPR2","bone morphogenetic protein receptor type 2",TRUE
+"203082_at",0.869971289491322,0.508030689723987,0.672801170723816,-5.72158153731384,0.194300481801269,"BMS1","BMS1, ribosome biogenesis factor",TRUE
+"1569525_s_at",0.739514744883547,0.227623111872798,1.24089514353093,-5.21629389031352,0.766490420614832,"BMS1P17///BMS1P18","BMS1, ribosome biogenesis factor pseudogene 17///BMS1, ribosome biogenesis factor pseudogene 18",TRUE
+"226802_s_at",0.762857166457304,0.262512712865745,-1.14973418888372,-5.31556679294031,-0.483141598510551,"BMS1P20","BMS1, ribosome biogenesis factor pseudogene 20",TRUE
+"233132_at",0.877275291808937,0.526783949649418,-0.643061501441819,-5.7402517193163,-0.223076902785253,"BMS1P20","BMS1, ribosome biogenesis factor pseudogene 20",TRUE
+"217179_x_at",0.931188266172628,0.695149426643249,0.397022412059156,-5.8631995433996,0.236977339942251,"BMS1P20","BMS1, ribosome biogenesis factor pseudogene 20",TRUE
+"224342_x_at",0.951879312464239,0.779471903281994,-0.28343892819532,-5.90062956038953,-0.205087488250374,"BMS1P20","BMS1, ribosome biogenesis factor pseudogene 20",TRUE
+"217180_at",0.991541426661437,0.960300452869145,-0.0503426121814255,-5.93844915376181,-0.0340487716892266,"BMS1P20","BMS1, ribosome biogenesis factor pseudogene 20",TRUE
+"215110_at",0.923494952314901,0.671618300365739,0.429624055136228,-5.85018059370062,0.283047220381807,"BMS1P21///MBL1P","BMS1, ribosome biogenesis factor pseudogene 21///mannose binding lectin 1, pseudogene",TRUE
+"238924_at",0.931582451098271,0.698233245832086,-0.392782900826102,-5.86481824709808,-0.187924090649445,"BMS1P5","BMS1, ribosome biogenesis factor pseudogene 5",TRUE
+"239151_at",0.964503386562183,0.836132263672142,0.20929247262809,-5.91837098161113,0.100732786948189,"BMS1P5","BMS1, ribosome biogenesis factor pseudogene 5",TRUE
+"1560047_s_at",0.567908857498119,0.057834778574294,-2.00061650524281,-4.15822114911783,-1.46505874409607,"BMS1P6","BMS1, ribosome biogenesis factor pseudogene 6",TRUE
+"231106_at",0.778686132916778,0.299356161931709,1.06271768170638,-5.4040888972084,0.461352733249537,"BMS1P6","BMS1, ribosome biogenesis factor pseudogene 6",TRUE
+"228149_at",0.936318756756998,0.715755301380207,-0.368830124792356,-5.87364185710263,-0.142608863196479,"BMT2","base methyltransferase of 25S rRNA 2 homolog",TRUE
+"206464_at",0.803894289501951,0.342436177457712,0.970165811212008,-5.4913611285206,0.525143480493616,"BMX","BMX non-receptor tyrosine kinase",TRUE
+"1552487_a_at",0.0162305996380512,1.00931026555782e-05,5.67890046641423,3.36985640597823,5.7871007808891,"BNC1","basonuclin 1",TRUE
+"206581_at",0.0714488726114362,0.000209596317390571,4.42685047265339,0.721272646876119,3.400834433966,"BNC1","basonuclin 1",TRUE
+"230722_at",0.677013732819214,0.143842883381917,1.51526310149553,-4.87927011327955,0.741152121038066,"BNC2","basonuclin 2",TRUE
+"235723_at",0.678126513742682,0.145390887555535,1.50914474764644,-4.88738286239484,1.29609540772449,"BNC2","basonuclin 2",TRUE
+"238478_at",0.67818193964437,0.145573002010743,1.50842846646449,-4.88833091344752,0.811142461910396,"BNC2","basonuclin 2",TRUE
+"220272_at",0.708193186381687,0.180022691759021,1.38439624489088,-5.04697147411681,0.798374001322572,"BNC2","basonuclin 2",TRUE
+"243445_at",0.840879524142924,0.430471403457057,0.803059260897562,-5.63036318061632,0.532619177049918,"BNC2","basonuclin 2",TRUE
+"229942_at",0.859465912277024,0.476717170764542,0.723873876817444,-5.6876383708152,0.661683355346795,"BNC2","basonuclin 2",TRUE
+"207829_s_at",0.708309103286544,0.180187170691354,-1.38385164718533,-5.04764337677632,-0.488945457946803,"BNIP1","BCL2 interacting protein 1",TRUE
+"37226_at",0.84899624366548,0.449692386219521,-0.769552296528057,-5.6552839196758,-0.251055406317255,"BNIP1","BCL2 interacting protein 1",TRUE
+"204930_s_at",0.9507311229803,0.775199210909007,-0.289091215316895,-5.89905957627173,-0.106064951593023,"BNIP1","BCL2 interacting protein 1",TRUE
+"226280_at",0.965992617204023,0.841100871083721,0.202853415343232,-5.9196609235843,0.0625160002917511,"BNIP2","BCL2 interacting protein 2",TRUE
+"209308_s_at",0.991215113882097,0.958785810275592,0.0522651108875252,-5.93835308631474,0.0170778164089302,"BNIP2","BCL2 interacting protein 2",TRUE
+"201849_at",0.632949074657601,0.10381872408652,-1.69638976768623,-4.62754337363669,-0.874639645615078,"BNIP3","BCL2 interacting protein 3",TRUE
+"201848_s_at",0.8376750578867,0.422320004155337,-0.817548267290771,-5.61927795910521,-0.460007311870115,"BNIP3","BCL2 interacting protein 3",TRUE
+"221479_s_at",0.95388518141013,0.786944605224153,0.273575892312034,-5.90329544357009,0.121987817867911,"BNIP3L","BCL2 interacting protein 3 like",TRUE
+"221478_at",0.99783553534859,0.989335910302615,0.0135174920389112,-5.9395944837038,0.00682271221834618,"BNIP3L","BCL2 interacting protein 3 like",TRUE
+"1553072_at",0.932249295738588,0.70097374052909,-0.389021520038011,-5.86624005962497,-0.426382820474967,"BNIPL","BCL2 interacting protein like",TRUE
+"236534_at",0.609970971583967,0.0820429866125312,-1.82161494489771,-4.44105912595552,-1.90332912021939,"BNIPL///C1orf56","BCL2 interacting protein like///chromosome 1 open reading frame 56",TRUE
+"230035_at",0.596215304217285,0.0726581174577004,-1.88468204890572,-4.34351869218634,-0.982236699014232,"BOC","BOC cell adhesion associated, oncogene regulated",TRUE
+"225990_at",0.739367922105944,0.227329534346141,-1.24170562910923,-5.21538189504245,-1.14885510963874,"BOC","BOC cell adhesion associated, oncogene regulated",TRUE
+"224184_s_at",0.764663346701144,0.264691696381634,-1.14434803676623,-5.32122490831317,-1.34926072548694,"BOC","BOC cell adhesion associated, oncogene regulated",TRUE
+"225030_at",0.753862100951903,0.247288830005896,-1.18832066052212,-5.27435147760818,-0.469016624808152,"BOD1","biorientation of chromosomes in cell division 1",TRUE
+"235009_at",0.781957703946186,0.303544038565228,1.05332498776226,-5.41327235217216,0.536788161016822,"BOD1L1","biorientation of chromosomes in cell division 1 like 1",TRUE
+"225821_s_at",0.81520955767687,0.366191984207479,0.922525278670504,-5.53345619987952,0.261495457966006,"BOD1L1","biorientation of chromosomes in cell division 1 like 1",TRUE
+"242594_at",0.841813886364358,0.434067031120534,-0.796722267724425,-5.63515294619188,-0.360037957966335,"BOD1L1","biorientation of chromosomes in cell division 1 like 1",TRUE
+"231368_at",0.73759219552868,0.224416142342969,-1.24979226263308,-5.20625441214783,-0.488013215819437,"BOD1L2","biorientation of chromosomes in cell division 1 like 2",TRUE
+"221454_at",0.831392326632573,0.405683075765359,-0.847675152863701,-5.59563480443719,-0.322346260065233,"BOK","BOK, BCL2 family apoptosis regulator",TRUE
+"223349_s_at",0.97897951922649,0.89792338051229,0.129764786409292,-5.9314852001038,0.125002267862328,"BOK","BOK, BCL2 family apoptosis regulator",TRUE
+"219345_at",0.812302873476553,0.358908777442039,-0.93690393484056,-5.52095613265754,-0.502576701464669,"BOLA1","bolA family member 1",TRUE
+"241644_at",0.75193462989549,0.245131976134152,1.19392957142026,-5.26826157335371,0.403551222139741,"BOLA2","bolA family member 2",TRUE
+"231500_s_at",0.913782990161554,0.638450140042051,0.476405302114386,-5.82973918288363,0.192699423756113,"BOLA2","bolA family member 2",TRUE
+"209836_x_at",0.77721449454957,0.296201525796605,-1.06985503597561,-5.39706170201474,-0.517692442184359,"BOLA2B///BOLA2","bolA family member 2B///bolA family member 2",TRUE
+"227291_s_at",0.963379172403332,0.833083092241987,0.213248509255985,-5.91755856112219,0.0583362341554192,"BOLA3","bolA family member 3",TRUE
+"236336_at",0.556381379241158,0.0519392234108205,2.05420473559896,-4.07006143803424,2.30984289765274,"BOLA3-AS1","BOLA3 antisense RNA 1 (head to head)",TRUE
+"228430_at",0.586168493787511,0.0660107622386665,1.93381606300338,-4.26591595587989,1.78463850600331,"BOLA3-AS1","BOLA3 antisense RNA 1 (head to head)",TRUE
+"236954_at",0.980009054680439,0.905448674569407,-0.120148087009727,-5.93265489529826,-0.0382402961417849,"BOLL","boule homolog, RNA binding protein",TRUE
+"219544_at",0.255716413540338,0.00369365815272163,3.2448394155721,-1.80595552849589,1.01530895170608,"BORA","bora, aurora kinase A activator",TRUE
+"227723_at",0.911617906576415,0.629954234042435,-0.488559481296846,-5.82409016922258,-0.22009121639714,"BORCS5","BLOC-1 related complex subunit 5",TRUE
+"1558739_at",0.992511588832933,0.965132627489982,0.0442105145748874,-5.93873152680183,0.0306409210579242,"BORCS5","BLOC-1 related complex subunit 5",TRUE
+"222882_s_at",0.75466931720949,0.248160944748229,1.18606311727232,-5.27679556325474,0.404731910286527,"BORCS6","BLOC-1 related complex subunit 6",TRUE
+"219417_s_at",0.819018525257656,0.374309613972514,-0.906722189079618,-5.54698910396362,-0.428816427718826,"BORCS6","BLOC-1 related complex subunit 6",TRUE
+"229950_s_at",0.968317867540591,0.85128345907792,0.189684361198284,-5.92217405209221,0.189010405236216,"BORCS6","BLOC-1 related complex subunit 6",TRUE
+"220101_x_at",0.998715736786698,0.994457622300486,0.00702519466107969,-5.93965944257566,0.00393524257492484,"BORCS6","BLOC-1 related complex subunit 6",TRUE
+"225334_at",0.746259710622309,0.237870988907426,1.21308850665845,-5.24727176421694,0.450605413877707,"BORCS7","BLOC-1 related complex subunit 7",TRUE
+"1553978_at",0.866602763987519,0.497787405684354,-0.689304796150893,-5.71087228376617,-0.222709251718113,"BORCS8","BLOC-1 related complex subunit 8",TRUE
+"209926_at",0.895690630367785,0.575342794647602,-0.56860496646342,-5.78342543781308,-0.313115978124365,"BORCS8","BLOC-1 related complex subunit 8",TRUE
+"220772_at",0.96927731102763,0.854275904230442,0.185820880320775,-5.92287946370268,0.101397732993883,"BPESC1","blepharophimosis, epicanthus inversus and ptosis, candidate 1 (non-protein coding)",TRUE
+"203502_at",0.733779920293333,0.217926261467273,1.26809886756362,-5.18540386579476,0.829493200062791,"BPGM","bisphosphoglycerate mutase",TRUE
+"205750_at",0.989475734766121,0.948141256883985,-0.0657821002340626,-5.93757603968081,-0.0238980265790456,"BPHL","biphenyl hydrolase like",TRUE
+"220542_s_at",0.857886999805586,0.473453924667773,0.729306589076859,-5.68388870759444,0.313881581758539,"BPIFA1","BPI fold containing family A member 1",TRUE
+"237099_at",0.972543181497623,0.867400012849567,0.168909934317239,-5.92579684042954,0.0729992856592085,"BPIFA2","BPI fold containing family A member 2",TRUE
+"240359_at",0.891225909060826,0.560435405762068,0.591100653142933,-5.77092165880133,0.180344455143705,"BPIFA3","BPI fold containing family A member 3",TRUE
+"1555554_at",0.99176128617116,0.96194734696279,0.0482524702700853,-5.93854951485714,0.0365769899264148,"BPIFA4P","BPI fold containing family A member 4, pseudogene",TRUE
+"226067_at",0.794426378358553,0.326144807870027,-1.00415547812311,-5.46014665456466,-1.93394544565543,"BPIFB1","BPI fold containing family B member 1",TRUE
+"232698_at",0.871451481476429,0.512801530633751,0.665178421569455,-5.72644410405991,0.466603644132646,"BPIFB2","BPI fold containing family B member 2",TRUE
+"233523_at",0.71454754703986,0.189680273908367,1.35306638781392,-5.08526709958489,0.991806772546161,"BPIFB4","BPI fold containing family B member 4",TRUE
+"1555535_at",0.72597222479724,0.205024913088142,-1.30577462778812,-5.14167974662784,-0.916830496512633,"BPIFB6","BPI fold containing family B member 6",TRUE
+"1555773_at",0.985031563903634,0.926113354748713,-0.0937971248626393,-5.93539925604075,-0.0559366385238942,"BPIFC","BPI fold containing family C",TRUE
+"232103_at",0.646392036827936,0.11724639103947,-1.62995535964966,-4.72242185013697,-0.912717272521498,"BPNT1","3'(2'), 5'-bisphosphate nucleotidase 1",TRUE
+"1554575_a_at",0.752913428584105,0.246105758947309,-1.19139268480032,-5.27101910482623,-0.680770163665882,"BPNT1","3'(2'), 5'-bisphosphate nucleotidase 1",TRUE
+"219391_at",0.90166870909171,0.598506827441359,-0.534223592173149,-5.80162607043577,-0.37793906499479,"BPNT1","3'(2'), 5'-bisphosphate nucleotidase 1",TRUE
+"209271_at",0.691970774776447,0.161435422830688,-1.44866903646214,-4.96614808869823,-0.533305688970446,"BPTF","bromodomain PHD finger transcription factor",TRUE
+"232909_s_at",0.83633038614858,0.417872661047703,-0.82552721032676,-5.61309411819091,-0.334268156334787,"BPTF","bromodomain PHD finger transcription factor",TRUE
+"230056_at",0.851733415458562,0.456361565085444,-0.758130568569365,-5.66354972352091,-0.317800407740285,"BPTF","bromodomain PHD finger transcription factor",TRUE
+"207186_s_at",0.888490704914061,0.5546099546047,-0.599975115229211,-5.76585994576417,-0.260735221877532,"BPTF","bromodomain PHD finger transcription factor",TRUE
+"231953_at",0.922168942129244,0.667763326367872,-0.435009462011793,-5.8479328909858,-0.16837310690781,"BPTF","bromodomain PHD finger transcription factor",TRUE
+"208331_at",0.937623890519979,0.723830395831552,0.357865818334192,-5.87749808498654,0.200141956977912,"BPY2","basic charge, Y-linked, 2",TRUE
+"243829_at",0.909052380289506,0.622843700527152,-0.498789362019197,-5.8192277708758,-0.194153652094347,"BRAF","B-Raf proto-oncogene, serine/threonine kinase",TRUE
+"226391_at",0.992057894338118,0.963207925394403,-0.0466527669923753,-5.93862345286134,-0.0162065071680679,"BRAF","B-Raf proto-oncogene, serine/threonine kinase",TRUE
+"236402_at",0.993083193605528,0.967254857047557,0.0415179385807048,-5.9388439458014,0.0173315520892832,"BRAF","B-Raf proto-oncogene, serine/threonine kinase",TRUE
+"209922_at",0.539609110035715,0.0444482797802118,-2.13076195679734,-3.94149292479364,-0.644154211981815,"BRAP","BRCA1 associated protein",TRUE
+"41512_at",0.867026157046741,0.498664920612562,-0.687883489714582,-5.71180433406147,-0.196109397043299,"BRAP","BRCA1 associated protein",TRUE
+"213473_at",0.891918115867831,0.56196191064483,-0.588783110205013,-5.77223150499803,-0.193473475042881,"BRAP","BRCA1 associated protein",TRUE
+"209923_s_at",0.948988685362499,0.769848086887394,0.296183758247411,-5.89704604873937,0.0815482033735648,"BRAP","BRCA1 associated protein",TRUE
+"225437_s_at",0.955892698633978,0.799796681610073,0.256676771350797,-5.90764516597479,0.0828996827117585,"BRAT1","BRCA1 associated ATM activator 1",TRUE
+"204531_s_at",0.831943055644609,0.408020930642182,-0.843394943071046,-5.59904256334698,-0.269795947479343,"BRCA1","BRCA1, DNA repair associated",TRUE
+"211851_x_at",0.959159773143252,0.814904248414273,0.236908733711919,-5.9123836114756,0.064042512452831,"BRCA1","BRCA1, DNA repair associated",TRUE
+"214727_at",0.611964994975857,0.0836927493960464,1.81118267558953,-4.45696466663504,0.725612278326329,"BRCA2","BRCA2, DNA repair associated",TRUE
+"208368_s_at",0.636147339487472,0.107567366798122,1.6771451163862,-4.65532381886135,0.769077393799508,"BRCA2","BRCA2, DNA repair associated",TRUE
+"221196_x_at",0.722937902375896,0.199610343318181,-1.32213611920934,-5.12235393934211,-0.66942319400323,"BRCC3","BRCA1/BRCA2-containing complex subunit 3",TRUE
+"216521_s_at",0.728262401376535,0.208524116456498,-1.29537876526411,-5.15385321131755,-0.507717323468048,"BRCC3","BRCA1/BRCA2-containing complex subunit 3",TRUE
+"229436_x_at",0.77093460090688,0.279439998550938,-1.10872252127768,-5.35805813303738,-0.485317360395026,"BRCC3","BRCA1/BRCA2-containing complex subunit 3",TRUE
+"231913_s_at",0.808266620412549,0.351158955978335,-0.952420777453497,-5.50726754134634,-0.39674800370625,"BRCC3","BRCA1/BRCA2-containing complex subunit 3",TRUE
+"204520_x_at",0.933400538871064,0.705374128514952,-0.382993808011107,-5.86849043159226,-0.165716558978936,"BRD1","bromodomain containing 1",TRUE
+"215460_x_at",0.967098323798013,0.846400011535454,-0.195995652830816,-5.9209905947238,-0.0797657610355937,"BRD1","bromodomain containing 1",TRUE
+"208685_x_at",0.868397087637799,0.503451674817321,0.680155270663131,-5.71684009045984,0.196426842342854,"BRD2","bromodomain containing 2",TRUE
+"214911_s_at",0.875187315707138,0.522135391144253,0.650378157913568,-5.73573351773954,0.203007804651827,"BRD2","bromodomain containing 2",TRUE
+"208686_s_at",0.989638901366417,0.950001640971038,0.0634188579660965,-5.93772472629023,0.0216406736813628,"BRD2","bromodomain containing 2",TRUE
+"212547_at",0.536497541130897,0.0433515525691139,-2.1429311632356,-3.92078029598644,-0.658827148890731,"BRD3","bromodomain containing 3",TRUE
+"203825_at",0.557528747907147,0.0523623250206347,-2.05018274577448,-4.07673145654052,-0.823299687941967,"BRD3","bromodomain containing 3",TRUE
+"1555028_at",0.976433695486417,0.888245839212272,0.142150460335747,-5.92984630604796,0.0721223867986414,"BRD3","bromodomain containing 3",TRUE
+"202102_s_at",0.40221114169538,0.0145946986900206,2.64938118085765,-2.99983726610827,0.750029718681574,"BRD4","bromodomain containing 4",TRUE
+"226054_at",0.545992239117952,0.0472644036167401,2.10071113320237,-3.9923199082675,0.696237768648626,"BRD4","bromodomain containing 4",TRUE
+"238612_at",0.613829220017112,0.0848414707941347,1.80402332501536,-4.46784197715131,0.729215282052623,"BRD4","bromodomain containing 4",TRUE
+"226052_at",0.828941412891522,0.399878002103592,0.85837188859519,-5.58704811728016,0.244307041992963,"BRD4","bromodomain containing 4",TRUE
+"202103_at",0.97922824128613,0.898921925396838,-0.128488027930465,-5.93164566874005,-0.049722046465682,"BRD4","bromodomain containing 4",TRUE
+"239000_at",0.992831036919018,0.966228431174411,-0.0428201745358018,-5.93879045715743,-0.0199976572325875,"BRD4","bromodomain containing 4",TRUE
+"240360_at",0.99872918752906,0.994630100621236,0.00680656761779415,-5.93966091544985,0.00323792118431498,"BRD4","bromodomain containing 4",TRUE
+"228289_at",0.862589597763622,0.485544298648613,0.70928625586486,-5.69757479570958,0.531975086769772,"BRD7","bromodomain containing 7",TRUE
+"222737_s_at",0.883410339479976,0.541411824119442,0.620263800966455,-5.75401451695572,0.485893602118438,"BRD7","bromodomain containing 7",TRUE
+"238545_at",0.932091525948902,0.700666880960217,0.389442405659499,-5.86608163354865,0.368181075834596,"BRD7","bromodomain containing 7",TRUE
+"221776_s_at",0.957571530817866,0.809099194348281,0.244492715209474,-5.9106103273191,0.321807982407597,"BRD7","bromodomain containing 7",TRUE
+"221093_at",0.675447258877226,0.141676222403382,1.5239179077623,-4.86774939545788,0.572584258606476,"BRD7P3","bromodomain containing 7 pseudogene 3",TRUE
+"1569960_at",0.982613314946763,0.915625746046441,-0.107160897321821,-5.93409185913925,-0.0938094492094104,"BRD7P3","bromodomain containing 7 pseudogene 3",TRUE
+"242265_at",0.762778023494851,0.262384310078497,1.15005261057599,-5.31523156155694,0.412088883754832,"BRD8","bromodomain containing 8",TRUE
+"202227_s_at",0.79782885150643,0.331466330409884,-0.992926599127876,-5.47056681492575,-0.301900109359609,"BRD8","bromodomain containing 8",TRUE
+"210352_at",0.89316156038085,0.567144794416362,0.58093856483497,-5.77662820133118,0.360546615812806,"BRD8","bromodomain containing 8",TRUE
+"220155_s_at",0.728385463227073,0.209320554370578,1.29303152512333,-5.1565903820314,0.747579734759423,"BRD9","bromodomain containing 9",TRUE
+"206787_at",0.970015053574756,0.858030874001572,0.180977004300469,-5.92374343915779,0.204995507801613,"BRDT","bromodomain testis associated",TRUE
+"205550_s_at",0.963790340813952,0.834603819082512,0.211275066409102,-5.91796572513202,0.060955119068236,"BRE","brain and reproductive organ-expressed (TNFRSF1A modulator)",TRUE
+"211566_x_at",0.990810941805126,0.955809127275017,0.0560439368909493,-5.938153768816,0.0192936326315358,"BRE","brain and reproductive organ-expressed (TNFRSF1A modulator)",TRUE
+"212645_x_at",0.991689960875868,0.960917096642188,-0.0495599774716358,-5.93848723130127,-0.0153602696432422,"BRE","brain and reproductive organ-expressed (TNFRSF1A modulator)",TRUE
+"1568768_s_at",0.998389341668871,0.993459023932235,-0.00829098769861759,-5.93964999985264,-0.0062805374066599,"BRE-AS1","BRE antisense RNA 1",TRUE
+"241475_at",0.969859842767097,0.855698433265424,-0.183985302165155,-5.92320954212659,-0.115086870438139,"BREA2","breast cancer estrogen-induced apoptosis 2",TRUE
+"203754_s_at",0.399312926596283,0.0141427755703049,-2.66345061419968,-2.97280911236994,-1.73649655747599,"BRF1","BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit",TRUE
+"215676_at",0.680972290639028,0.148843418192773,-1.49568851658398,-4.90513292417008,-0.870704067075899,"BRF1","BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit",TRUE
+"215677_s_at",0.821161081591471,0.382217254054346,-0.891544290209345,-5.55978323074697,-0.670846404072112,"BRF1","BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit",TRUE
+"1552399_a_at",0.833956476774481,0.411783557197389,-0.836538877372729,-5.60446756549127,-0.359485733754139,"BRF1","BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit",TRUE
+"218954_s_at",0.801560848966415,0.338518540217272,-0.978236043184217,-5.48403841139889,-0.852266546490617,"BRF2","BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit",TRUE
+"218955_at",0.806086691531913,0.34645141589956,-0.961959733329475,-5.49875031332644,-0.606402724782111,"BRF2","BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit",TRUE
+"223376_s_at",0.637485146909712,0.108824416304416,1.67081882284746,-4.66440367826855,0.833122447473809,"BRI3","brain protein I3",TRUE
+"229798_s_at",0.828076026336893,0.397900804708613,0.862037917585976,-5.58408218047483,0.304315598856219,"BRI3","brain protein I3",TRUE
+"225716_at",0.913627134030439,0.637613490985061,-0.477598949814491,-5.82919056273453,-0.217435391974641,"BRI3BP","BRI3 binding protein",TRUE
+"1553990_at",0.76711764189372,0.268959784447199,-1.13389177305051,-5.33214230291928,-0.532868729641809,"BRICD5","BRICHOS domain containing 5",TRUE
+"1555457_at",0.774230543658252,0.287608777008573,1.08957635288854,-5.37742631624046,0.625244691132577,"BRINP1","BMP/retinoic acid inducible neural specific 1",TRUE
+"205818_at",0.958168888251508,0.811030598617129,0.241967837418647,-5.91120686292714,0.1548985754064,"BRINP1","BMP/retinoic acid inducible neural specific 1",TRUE
+"214822_at",0.739508010556618,0.227607513518917,-1.24093818619547,-5.21624546963276,-1.75092695032905,"BRINP2","BMP/retinoic acid inducible neural specific 2",TRUE
+"217562_at",0.904381089098038,0.607259098978418,-0.52140288829885,-5.80813050001428,-0.954924505865577,"BRINP3","BMP/retinoic acid inducible neural specific 3",TRUE
+"221703_at",0.977254232093199,0.89131663085124,0.138217975487997,-5.93038280658805,0.109222229204311,"BRIP1","BRCA1 interacting protein C-terminal helicase 1",TRUE
+"235609_at",0.996074388710409,0.98043990960176,-0.0247956716550174,-5.93938402643474,-0.0169796663581678,"BRIP1","BRCA1 interacting protein C-terminal helicase 1",TRUE
+"219177_at",0.670164229230396,0.135970986955544,1.54723948185551,-4.83644590134342,0.716574080533084,"BRIX1","BRX1, biogenesis of ribosomes",TRUE
+"224575_at",0.580630437263151,0.063184979631041,-1.95603259537368,-4.23037500629347,-0.60450062661366,"BRK1","BRICK1, SCAR/WAVE actin nucleating complex subunit",TRUE
+"224023_s_at",0.993615552413264,0.970149937927371,0.0378453116667232,-5.93898590007882,0.0103867356081899,"BRK1","BRICK1, SCAR/WAVE actin nucleating complex subunit",TRUE
+"215631_s_at",0.957430653957785,0.807649920511254,-0.246388382187842,-5.91015840457634,-0.0758614463181075,"BRMS1","breast cancer metastasis suppressor 1",TRUE
+"226580_at",0.910165867297668,0.626771625465081,-0.493131681638076,-5.82192910532016,-0.135771802590151,"BRMS1L","breast cancer metastasis-suppressor 1-like",TRUE
+"224484_s_at",0.91539387234353,0.64328845000337,-0.46951616761255,-5.83287928947886,-0.19016791236259,"BRMS1L","breast cancer metastasis-suppressor 1-like",TRUE
+"241908_at",0.8920930097751,0.564074324622904,-0.585581394208316,-5.77403288774973,-0.217839697377975,"BROX","BRO1 domain and CAAX motif containing",TRUE
+"239078_at",0.939452234779565,0.728791883344723,-0.351151336392472,-5.87980287059718,-0.393512564157104,"BROX","BRO1 domain and CAAX motif containing",TRUE
+"226128_at",0.990810941805126,0.956146132440293,0.0556160761733688,-5.93817703472912,0.0186562533219146,"BROX","BRO1 domain and CAAX motif containing",TRUE
+"204481_at",0.718706241731185,0.194712489424404,-1.33723739414223,-5.1043367680524,-0.421248638922151,"BRPF1","bromodomain and PHD finger containing 1",TRUE
+"1565844_at",0.772116141939407,0.282442282295421,1.1016391717089,-5.36525857354816,0.406025927921816,"BRPF3","bromodomain and PHD finger containing 3",TRUE
+"225217_s_at",0.980001024522674,0.905096145117457,-0.120598324081718,-5.93260213793116,-0.044413442937941,"BRPF3","bromodomain and PHD finger containing 3",TRUE
+"1565843_s_at",0.986595591190249,0.937495881933209,-0.0793127055692993,-5.93662007195199,-0.0220016408539339,"BRPF3","bromodomain and PHD finger containing 3",TRUE
+"207369_at",0.819018525257656,0.37397214524642,0.90737460885586,-5.54643467696901,0.504053302291728,"BRS3","bombesin receptor subtype 3",TRUE
+"1552818_a_at",0.935248376892166,0.712088791616716,0.373823649074846,-5.87184753323822,0.297315971416706,"BRS3","bombesin receptor subtype 3",TRUE
+"1552504_a_at",0.892689821944014,0.565174293247448,-0.583916653105972,-5.77496576682812,-0.371469573366297,"BRSK1","BR serine/threonine kinase 1",TRUE
+"223715_at",0.79538417858623,0.327464066940577,1.00135995474962,-5.46275078253253,0.735031411649857,"BRSK2","BR serine/threonine kinase 2",TRUE
+"215010_s_at",0.932463081848018,0.702071791995528,0.387516028417666,-5.86680536153534,0.365395778601529,"BRSK2","BR serine/threonine kinase 2",TRUE
+"231960_at",0.615821255316333,0.0868459235712297,-1.79172884616038,-4.48644827900068,-0.77078270737309,"BRWD1","bromodomain and WD repeat domain containing 1",TRUE
+"214820_at",0.694526899259872,0.164085941756054,-1.43915226974092,-4.97830494974076,-0.511760025486062,"BRWD1","bromodomain and WD repeat domain containing 1",TRUE
+"225446_at",0.740610299769501,0.230451709002504,1.23312665242842,-5.22500932980247,0.484352633249552,"BRWD1","bromodomain and WD repeat domain containing 1",TRUE
+"219280_at",0.774230543658252,0.290123776733185,-1.08376081509659,-5.38324979342543,-0.480493426872387,"BRWD1","bromodomain and WD repeat domain containing 1",TRUE
+"238890_at",0.859336186745721,0.476355942348227,-0.724474181159605,-5.68722534960636,-0.440518741092844,"BRWD1","bromodomain and WD repeat domain containing 1",TRUE
+"244622_at",0.885131437506849,0.546183163028918,0.612899240162408,-5.75835819698723,0.470248195528258,"BRWD1","bromodomain and WD repeat domain containing 1",TRUE
+"1553227_s_at",0.890589821844314,0.559331298264223,-0.59277894890851,-5.76997000139416,-0.21081245668036,"BRWD1","bromodomain and WD repeat domain containing 1",TRUE
+"231860_at",0.932091525948902,0.699935503256615,-0.390445845233321,-5.8657032466055,-0.159698087112739,"BRWD1","bromodomain and WD repeat domain containing 1",TRUE
+"239602_at",0.897949253801113,0.586606471626498,-0.551802808542865,-5.79245775352064,-0.181610283229485,"BRWD1-IT2","BRWD1 intronic transcript 2 (non-protein coding)",TRUE
+"244738_at",0.734577729521114,0.218957837621705,1.26516131841354,-5.1887671106667,0.387747081858702,"BRWD3","bromodomain and WD repeat domain containing 3",TRUE
+"1553252_a_at",0.95194340202313,0.78037595285009,-0.282244187248294,-5.9009574747636,-0.11622625459054,"BRWD3","bromodomain and WD repeat domain containing 3",TRUE
+"235156_at",0.962125056232529,0.828005401163503,0.219844141310718,-5.91617039430047,0.140024503550523,"BRWD3","bromodomain and WD repeat domain containing 3",TRUE
+"222200_s_at",0.632949074657601,0.103932315394644,-1.6957980234295,-4.62840114197607,-0.455150492254978,"BSDC1","BSD domain containing 1",TRUE
+"218004_at",0.801086839730802,0.337182119072059,-0.981003677994245,-5.48151439993168,-0.257231249482137,"BSDC1","BSD domain containing 1",TRUE
+"1559971_at",0.908709061737317,0.620626657658014,-0.501990021351701,-5.81768625023995,-0.344258649692559,"BSDC1","BSD domain containing 1",TRUE
+"208677_s_at",0.907610731888632,0.616910954113768,-0.507366201605519,-5.81507528875164,-0.212585187355929,"BSG","basigin (Ok blood group)",TRUE
+"204586_at",0.984244246588495,0.92346054929692,0.0971756949338603,-5.93508513366892,0.0673431303885703,"BSN","bassoon presynaptic cytomatrix protein",TRUE
+"1564131_a_at",0.595997098747707,0.0725836766741869,-1.88521005845977,-4.34269216320454,-1.13892925624905,"BSN-AS2","BSN antisense RNA 2 (head to head)",TRUE
+"1552548_at",0.56861088242915,0.0582581946227564,-1.99695772963728,-4.16418370695134,-0.881983957326008,"BSND","barttin CLCNK type accessory beta subunit",TRUE
+"237736_at",0.571677937624457,0.0596548667535279,1.98505396858317,-4.18353202770486,1.18459115481499,"BSND","barttin CLCNK type accessory beta subunit",TRUE
+"1552549_a_at",0.986889306520757,0.938972122089203,-0.0774355104146238,-5.93676334638775,-0.0323652662669831,"BSND","barttin CLCNK type accessory beta subunit",TRUE
+"222746_s_at",0.973071267819624,0.87021905310476,0.165284226987097,-5.92638621672867,0.190943213947463,"BSPRY","B-box and SPRY domain containing",TRUE
+"218792_s_at",0.986889306520757,0.939568189594817,0.0766776288576982,-5.9368202188436,0.0855053829341657,"BSPRY","B-box and SPRY domain containing",TRUE
+"205715_at",0.600087813329005,0.0764649487749388,1.85829030355875,-4.38462335207989,1.75343869554607,"BST1","bone marrow stromal cell antigen 1",TRUE
+"201641_at",0.603702127972549,0.0779668394974168,-1.84819239687073,-4.4002419895282,-2.45202518513618,"BST2","bone marrow stromal cell antigen 2",TRUE
+"209430_at",0.82847108093969,0.398486403344698,0.860950907858123,-5.58496283380475,0.225970553014236,"BTAF1","B-TFIID TATA-box binding protein associated factor 1",TRUE
+"217945_at",0.889565281631985,0.557802580987124,-0.595105512058309,-5.76864643829152,-0.180588390434108,"BTBD1","BTB domain containing 1",TRUE
+"223174_at",0.646843064993255,0.117940164881898,1.62670036996303,-4.72699590104796,0.635100493446686,"BTBD10","BTB domain containing 10",TRUE
+"238692_at",0.674396001813823,0.140775154434406,1.5275492641124,-4.86290000938268,1.61802616055749,"BTBD11","BTB domain containing 11",TRUE
+"228570_at",0.811527120049391,0.355700712484244,0.943299502838914,-5.51533909775287,0.965052497187437,"BTBD11","BTB domain containing 11",TRUE
+"1552566_at",0.481098695192659,0.0272248626049581,2.3645425889691,-3.53119589747532,1.71726984746744,"BTBD16","BTB domain containing 16",TRUE
+"230445_at",0.970271320001985,0.858550898260291,0.180306529736489,-5.92386123586199,0.0975889241781798,"BTBD17","BTB domain containing 17",TRUE
+"215349_at",0.42510292927997,0.0180148785942696,2.55451808935222,-3.18025012024494,1.64402951423378,"BTBD18","BTB domain containing 18",TRUE
+"1557049_at",0.948668195792872,0.766247452710426,0.300964870349627,-5.8956614180502,0.157337085644788,"BTBD19","BTB domain containing 19",TRUE
+"238102_s_at",0.971216837324271,0.862152703509124,0.175664975231253,-5.92466476412207,0.0651994493064505,"BTBD19","BTB domain containing 19",TRUE
+"207722_s_at",0.975398143273847,0.882432739298941,-0.149601114293958,-5.9287886430078,-0.0597236517265696,"BTBD2","BTB domain containing 2",TRUE
+"202946_s_at",0.956734254923335,0.803978911452238,-0.251194254150191,-5.90899714694953,-0.146834788417435,"BTBD3","BTB domain containing 3",TRUE
+"225389_at",0.812302873476553,0.356772543355918,-0.941158407490944,-5.51722346261332,-0.355476266890232,"BTBD6","BTB domain containing 6",TRUE
+"1556000_s_at",0.737123149977386,0.222837559256769,1.25420742979462,-5.2012494848876,0.44114072586537,"BTBD7","BTB domain containing 7",TRUE
+"224943_at",0.859483694145165,0.477050015362843,0.7233209775502,-5.6880184884744,0.265202357611436,"BTBD7","BTB domain containing 7",TRUE
+"220297_at",0.962125056232529,0.827980185257869,-0.219876919992036,-5.91616339034811,-0.0825595887343571,"BTBD7","BTB domain containing 7",TRUE
+"217141_at",0.973936963444057,0.873818523432239,-0.160658057612097,-5.92711970256186,-0.0858875012184619,"BTBD7","BTB domain containing 7",TRUE
+"224945_at",0.990810941805126,0.954255761539629,0.0580162251178287,-5.93804421650971,0.0160996453456335,"BTBD7","BTB domain containing 7",TRUE
+"1569693_at",0.92265243752289,0.669474488590969,-0.432617360373374,-5.84893467496013,-0.294286539706577,"BTBD8","BTB domain containing 8",TRUE
+"234682_at",0.698391916012681,0.169567196684262,1.41985750568509,-5.00275121990029,0.636283380618034,"BTBD9","BTB domain containing 9",TRUE
+"229867_at",0.778580821633075,0.298679831448267,-1.06424333895729,-5.40259032729792,-0.435176994533177,"BTBD9","BTB domain containing 9",TRUE
+"1553375_at",0.778580821633075,0.298871380140565,-1.06381099605437,-5.40301518972388,-0.623709628121686,"BTBD9","BTB domain containing 9",TRUE
+"235248_at",0.909052380289506,0.621987666227505,0.500024558124769,-5.81863400882536,0.21149842428807,"BTBD9","BTB domain containing 9",TRUE
+"241412_at",0.923376218980614,0.670961892545628,0.430540142030586,-5.84980018846615,0.478300296752942,"BTC","betacellulin",TRUE
+"207326_at",0.965992617204023,0.840853918433366,0.203173243747649,-5.91959779953291,0.213114387150479,"BTC","betacellulin",TRUE
+"237190_at",0.716749536957327,0.192721883418617,1.34346004778933,-5.09686258453085,0.44063203503497,"BTD","biotinidase",TRUE
+"214117_s_at",0.88698237223329,0.551114119089341,-0.605324032975795,-5.76277390669334,-0.272104758117761,"BTD","biotinidase",TRUE
+"204167_at",0.931370027472813,0.695802383212869,0.396124137933207,-5.86354394601484,0.180869833036176,"BTD","biotinidase",TRUE
+"214116_at",0.97070558355376,0.860440468187279,-0.177870990286847,-5.92428547214387,-0.0702146693314587,"BTD","biotinidase",TRUE
+"243165_at",0.910165867297668,0.626767246839195,-0.493137979385956,-5.82192611510904,-0.391202975578544,"BTF3","basic transcription factor 3",TRUE
+"211939_x_at",0.931370027472813,0.695818806961011,-0.39610154801748,-5.86355259719257,-0.0967910245170849,"BTF3","basic transcription factor 3",TRUE
+"208517_x_at",0.932739823750021,0.702902921164756,-0.386377108724671,-5.86723158276024,-0.10148431012859,"BTF3","basic transcription factor 3",TRUE
+"214800_x_at",0.975242094553739,0.879919768403005,0.152824651745898,-5.9283143373424,0.0378874175899142,"BTF3","basic transcription factor 3",TRUE
+"238675_x_at",0.485255613602953,0.0280218439673835,-2.35105019268106,-3.55555413626587,-0.791482815855483,"BTF3L4","basic transcription factor 3 like 4",TRUE
+"235819_at",0.691398701015407,0.161092419793969,-1.44990978911902,-4.96455832298712,-0.608283230099507,"BTF3L4","basic transcription factor 3 like 4",TRUE
+"243972_at",0.91339551560427,0.636972050725143,0.478514569893614,-5.82876881848849,0.281234626355118,"BTF3L4","basic transcription factor 3 like 4",TRUE
+"226963_at",0.922168942129244,0.667908723402652,-0.434806105609988,-5.84801826521455,-0.120576567394405,"BTF3L4","basic transcription factor 3 like 4",TRUE
+"225976_at",0.927751423245943,0.682904294158265,-0.413930767732806,-5.85657354486777,-0.120083218459804,"BTF3L4","basic transcription factor 3 like 4",TRUE
+"208529_at",0.571677937624457,0.0595597422873339,1.98585682468272,-4.18222951775719,1.62392730158092,"BTF3P11","basic transcription factor 3 pseudogene 11",TRUE
+"217461_x_at",0.91238586368984,0.632949093727087,0.484266629690534,-5.82610129090493,0.1501118530412,"BTF3P12","basic transcription factor 3 pseudogene 12",TRUE
+"217467_at",0.936992192746977,0.719128913688794,0.364243932744575,-5.87526883232516,0.284781530620602,"BTF3P13","basic transcription factor 3 pseudogene 13",TRUE
+"1559975_at",0.673366993714442,0.139191802801906,1.53397679362428,-4.854294071537,1.08605072047238,"BTG1","BTG anti-proliferation factor 1",TRUE
+"200920_s_at",0.727517287864136,0.20785637958346,1.29735205859261,-5.15154884805447,0.922083783510489,"BTG1","BTG anti-proliferation factor 1",TRUE
+"200921_s_at",0.758349492775124,0.25534913876525,1.16767783669492,-5.29654883737694,0.692596142586988,"BTG1","BTG anti-proliferation factor 1",TRUE
+"201236_s_at",0.839519981963042,0.428116640149639,-0.807227137606125,-5.62719349155162,-0.601178911192168,"BTG2","BTG anti-proliferation factor 2",TRUE
+"201235_s_at",0.877823095900289,0.528652603177116,-0.640130256550867,-5.74204805065564,-0.563797767222657,"BTG2","BTG anti-proliferation factor 2",TRUE
+"1556213_a_at",0.358427723880268,0.0100137648944666,2.81628764603851,-2.67501862544143,2.40069371754018,"BTG3","BTG anti-proliferation factor 3",TRUE
+"213134_x_at",0.547195868806649,0.0476454544565737,2.09676937191366,-3.99895263545615,2.7769982864692,"BTG3","BTG anti-proliferation factor 3",TRUE
+"205548_s_at",0.554642754132296,0.0512114171782497,2.06119225490101,-4.05845309714552,2.96477244758132,"BTG3","BTG anti-proliferation factor 3",TRUE
+"215425_at",0.750807729565285,0.243876327449897,1.19721195049383,-5.26468613599459,0.701376941914553,"BTG3","BTG anti-proliferation factor 3",TRUE
+"1554362_at",0.748659576527171,0.241638693131687,-1.20309292151118,-5.2582587574342,-0.886129929169694,"BTG4","BTG anti-proliferation factor 4",TRUE
+"220766_at",0.998347572104896,0.99244862376011,-0.00957175448453519,-5.93963885686204,-0.00692498471929337,"BTG4","BTG anti-proliferation factor 4",TRUE
+"205504_at",0.8920930097751,0.563178756470746,0.58693802101345,-5.77327076821836,0.309903059956759,"BTK","Bruton tyrosine kinase",TRUE
+"236226_at",0.94214388523134,0.739682054949399,0.336470459179301,-5.88469184326703,0.268880170995162,"BTLA","B and T lymphocyte associated",TRUE
+"207395_at",0.407748633394319,0.0155901243747986,2.61978411757073,-3.05647079642346,1.63344375837827,"BTN1A1","butyrophilin subfamily 1 member A1",TRUE
+"211256_x_at",0.594303508881191,0.0712478508069861,1.89476654830713,-4.32770470172866,0.724187590518648,"BTN2A1","butyrophilin subfamily 2 member A1",TRUE
+"244063_at",0.603880482874875,0.0784409545382233,-1.84503984975475,-4.40510569032958,-0.95685467691454,"BTN2A1","butyrophilin subfamily 2 member A1",TRUE
+"203944_x_at",0.67606695078322,0.142485305594104,1.5206733760112,-4.87207443412321,0.468936110530448,"BTN2A1","butyrophilin subfamily 2 member A1",TRUE
+"215493_x_at",0.695739345331756,0.165058400506781,1.43569166753912,-4.98270936047644,0.445473071010154,"BTN2A1","butyrophilin subfamily 2 member A1",TRUE
+"1564684_at",0.521655713381635,0.0379268682185586,2.20755326180902,-3.80956229912016,0.841447740960473,"BTN2A2","butyrophilin subfamily 2 member A2",TRUE
+"205298_s_at",0.603702127972549,0.0775792583056559,1.85078196496134,-4.39624242130782,0.663490571843836,"BTN2A2","butyrophilin subfamily 2 member A2",TRUE
+"205299_s_at",0.697699759202153,0.168432215243319,1.42381125045447,-4.997763887959,1.17755209399003,"BTN2A2","butyrophilin subfamily 2 member A2",TRUE
+"208585_at",0.835223580564215,0.414231789058488,0.832099152796399,-5.60795851286999,0.425615087049105,"BTN2A3P","butyrophilin subfamily 2 member A3, pseudogene",TRUE
+"209770_at",0.454464357519116,0.021993830635493,2.46340223281947,-3.3503778461547,1.08475331306247,"BTN3A1","butyrophilin subfamily 3 member A1",TRUE
+"207485_x_at",0.468735421183467,0.0248405963548126,2.40720032468878,-3.45367226059118,2.27273326804876,"BTN3A1","butyrophilin subfamily 3 member A1",TRUE
+"209846_s_at",0.150618166766275,0.00108111011376197,3.75604902369997,-0.725344204548543,2.72211242173295,"BTN3A2","butyrophilin subfamily 3 member A2",TRUE
+"212613_at",0.342768485256544,0.00858253418045192,2.88370699869174,-2.54138665099037,3.54966828005454,"BTN3A2","butyrophilin subfamily 3 member A2",TRUE
+"204820_s_at",0.409937516868549,0.0158404472725799,2.61262113152873,-3.07013076281781,2.94517513454578,"BTN3A2///BTN3A3","butyrophilin subfamily 3 member A2///butyrophilin subfamily 3 member A3",TRUE
+"38241_at",0.308621629697291,0.00636385036478523,3.01313951285398,-2.28134945698503,3.08640768178728,"BTN3A3","butyrophilin subfamily 3 member A3",TRUE
+"204821_at",0.319095917986488,0.00699795430631995,2.9722112840422,-2.36404738325692,3.10524818993246,"BTN3A3","butyrophilin subfamily 3 member A3",TRUE
+"221457_s_at",0.606900628956089,0.0803796115474369,1.83231897247183,-4.42467100439195,0.684691078253717,"BTNL2","butyrophilin like 2",TRUE
+"217207_s_at",0.994825233837873,0.975849251277314,0.0306168154989409,-5.93922692325148,0.0103368707314972,"BTNL3","butyrophilin like 3",TRUE
+"220421_at",0.70140001480371,0.173095389112875,-1.40770076901417,-5.01801455190043,-1.18916781244146,"BTNL8","butyrophilin like 8",TRUE
+"229985_at",0.827825169467994,0.396920508121351,-0.86385988925656,-5.58260377052332,-0.692649252246018,"BTNL9","butyrophilin like 9",TRUE
+"228434_at",0.831487912516861,0.406044235384134,-0.847012906083201,-5.5961631154859,-0.637140180541857,"BTNL9","butyrophilin like 9",TRUE
+"241496_at",0.872668627020452,0.516399808290774,-0.659455279565323,-5.73006001259363,-0.291410416376259,"BTNL9","butyrophilin like 9",TRUE
+"1553279_at",0.979588787486838,0.901525857882741,0.125159613453593,-5.93205655049531,0.099636820474549,"BTNL9","butyrophilin like 9",TRUE
+"230992_at",0.980001024522674,0.905070331885358,0.120631292752155,-5.93259826702286,0.0473649738065163,"BTNL9","butyrophilin like 9",TRUE
+"1563620_at",0.766518138308969,0.267170300169255,1.13826082124149,-5.32759131989874,1.1850142163784,"BTRC","beta-transducin repeat containing E3 ubiquitin protein ligase",TRUE
+"224471_s_at",0.774230543658252,0.287621431663676,1.08954699946179,-5.37745577949156,0.338695830528799,"BTRC","beta-transducin repeat containing E3 ubiquitin protein ligase",TRUE
+"204901_at",0.865345395265289,0.494765357643811,0.694210540778005,-5.70764113084568,0.331862074124817,"BTRC","beta-transducin repeat containing E3 ubiquitin protein ligase",TRUE
+"216091_s_at",0.882562076266907,0.540253268527056,0.622057242880361,-5.75294915999837,0.214410300637263,"BTRC","beta-transducin repeat containing E3 ubiquitin protein ligase",TRUE
+"222374_at",0.94895689004559,0.768614841990424,-0.297820526744223,-5.8965745081804,-0.1936303239095,"BTRC","beta-transducin repeat containing E3 ubiquitin protein ligase",TRUE
+"216277_at",0.711175809551218,0.184977250802522,1.368161685572,-5.06690668968677,0.894266555765769,"BUB1","BUB1 mitotic checkpoint serine/threonine kinase",TRUE
+"216275_at",0.716472449896956,0.192182115439337,1.34515605970038,-5.09482041673062,0.625133173384413,"BUB1","BUB1 mitotic checkpoint serine/threonine kinase",TRUE
+"209642_at",0.723225884957328,0.199884158163515,1.32130046671013,-5.12334591481828,0.45704913869125,"BUB1","BUB1 mitotic checkpoint serine/threonine kinase",TRUE
+"215508_at",0.94118897722809,0.736873074700057,-0.340249862408875,-5.8834529699201,-0.260712764151569,"BUB1","BUB1 mitotic checkpoint serine/threonine kinase",TRUE
+"215509_s_at",0.952244853763632,0.781406814978676,0.280882369628999,-5.90132956947444,0.099604578514402,"BUB1","BUB1 mitotic checkpoint serine/threonine kinase",TRUE
+"203755_at",0.87579870142401,0.523465501873171,0.648280981272421,-5.73703359043377,0.270368290932817,"BUB1B","BUB1 mitotic checkpoint serine/threonine kinase B",TRUE
+"237245_at",0.539609110035715,0.0444805570237262,-2.13040792918537,-3.94209438332611,-1.95648971281407,"BUB3","BUB3, mitotic checkpoint protein",TRUE
+"229827_at",0.835952408568777,0.415957962319458,-0.828978805694105,-5.61040164008818,-0.611294217685593,"BUB3","BUB3, mitotic checkpoint protein",TRUE
+"201458_s_at",0.849935057946582,0.451938059433704,0.765694974390911,-5.65808849159795,0.290672001211917,"BUB3","BUB3, mitotic checkpoint protein",TRUE
+"201456_s_at",0.856257656023992,0.470017902277169,0.735050790216313,-5.67989509598546,0.339491960273607,"BUB3","BUB3, mitotic checkpoint protein",TRUE
+"201457_x_at",0.87106619978761,0.51150900304431,0.667239668426063,-5.7251344652638,0.252511955229211,"BUB3","BUB3, mitotic checkpoint protein",TRUE
+"209974_s_at",0.978210818668419,0.894355159621335,-0.134329002720466,-5.93089859653698,-0.0430622272195578,"BUB3","BUB3, mitotic checkpoint protein",TRUE
+"224504_s_at",0.834265235157814,0.412252506779314,0.835687172942029,-5.60513860515476,0.251252519717976,"BUD13","BUD13 homolog",TRUE
+"215815_at",0.714590421965913,0.190005577055535,1.35203321769261,-5.08651752207601,0.600124754620198,"BUD31","BUD31 homolog",TRUE
+"205690_s_at",0.955730092376044,0.797294352451823,-0.259960931188744,-5.906821405876,-0.0868909692237452,"BUD31","BUD31 homolog",TRUE
+"228783_at",0.410469318323697,0.0159286685468707,2.61012199873113,-3.07489237010439,1.85261588087129,"BVES","blood vessel epicardial substance",TRUE
+"223853_at",0.575115532641373,0.0607250474611549,1.97609888832413,-4.19803615424257,1.46947227677454,"BVES","blood vessel epicardial substance",TRUE
+"232492_at",0.411110107932987,0.0161169859135969,2.60483053580382,-3.08496685724251,2.02566432664449,"BVES-AS1","BVES antisense RNA 1",TRUE
+"203612_at",0.932415412515157,0.701968391177558,-0.387657757942419,-5.86675223517365,-0.171700148995676,"BYSL","bystin like",TRUE
+"200777_s_at",0.885908342011285,0.547894004147592,-0.610266876670298,-5.75989865013534,-0.181194856513345,"BZW1","basic leucine zipper and W2 domains 1",TRUE
+"200776_s_at",0.990810941805126,0.953484494953433,0.0589955793711466,-5.93798841022691,0.0162551658754815,"BZW1","basic leucine zipper and W2 domains 1",TRUE
+"217809_at",0.863719378931144,0.489196122676922,0.703296277279115,-5.70159910130461,0.262019873888583,"BZW2","basic leucine zipper and W2 domains 2",TRUE
+"209182_s_at",0.774011928861764,0.285695274604444,1.09402563050663,-5.3729522172535,1.03715234909918,"C10orf10","chromosome 10 open reading frame 10",TRUE
+"209183_s_at",0.79223721651462,0.323038619203968,1.01076870492969,-5.45396000796117,1.25326130422951,"C10orf10","chromosome 10 open reading frame 10",TRUE
+"1553630_at",0.87754354850942,0.527853186605604,0.641383561281843,-5.7412809631229,0.665896776380015,"C10orf107","chromosome 10 open reading frame 107",TRUE
+"223703_at",0.768852835478002,0.273215751100329,1.12358574126511,-5.34281625747422,0.411470216909275,"C10orf11","chromosome 10 open reading frame 11",TRUE
+"244077_at",0.951102506952277,0.776640917601633,0.287182935101331,-5.89959306063064,0.131134494329991,"C10orf113","chromosome 10 open reading frame 113",TRUE
+"216393_at",0.538508613666048,0.0440173141285785,2.13551127252315,-3.93341819321711,1.35764254198011,"C10orf12","chromosome 10 open reading frame 12",TRUE
+"226892_at",0.813021058415276,0.362075332765795,-0.930628678473589,-5.52643338096832,-0.291748127393578,"C10orf12","chromosome 10 open reading frame 12",TRUE
+"219601_s_at",0.999758272335518,0.999400752245499,0.00075956504339869,-5.93968319974337,0.000769826114907168,"C10orf12","chromosome 10 open reading frame 12",TRUE
+"1553915_at",0.82979599608837,0.401322277541194,0.855701337615834,-5.58920126983647,1.15455848109983,"C10orf126","chromosome 10 open reading frame 126",TRUE
+"228372_at",0.867834927246481,0.5008581422971,0.684337339540632,-5.71412177914772,0.660176954915404,"C10orf128","chromosome 10 open reading frame 128",TRUE
+"1561890_at",0.941177694125685,0.736382247815428,0.340910773409832,-5.8832349201381,0.151562071032369,"C10orf128","chromosome 10 open reading frame 128",TRUE
+"218590_at",0.996898592071515,0.984026277947017,0.0202486302255915,-5.93948378341665,0.00655015881527632,"C10orf2","chromosome 10 open reading frame 2",TRUE
+"1552422_at",0.829030239823335,0.400039839440884,0.858072333850253,-5.58728994674332,0.57428457577357,"C10orf25","chromosome 10 open reading frame 25",TRUE
+"226313_at",0.907964244160782,0.617785912588383,-0.506098882360991,-5.81569321139672,-0.182778704155952,"C10orf35","chromosome 10 open reading frame 35",TRUE
+"1555051_at",0.873230718105642,0.517753379246604,0.65730812210257,-5.7314088689769,0.315045535134248,"C10orf53","chromosome 10 open reading frame 53",TRUE
+"239998_at",0.901430889731657,0.598209466623673,-0.534660762532801,-5.8014015666448,-0.395772004238776,"C10orf53","chromosome 10 open reading frame 53",TRUE
+"225373_at",0.0691276045601358,0.000192179165855339,4.46224374699027,0.797656808500845,3.06784775895313,"C10orf54","chromosome 10 open reading frame 54",TRUE
+"225372_at",0.364513221153898,0.0106071383783255,2.79099456447017,-2.72480738376501,2.20373025098599,"C10orf54","chromosome 10 open reading frame 54",TRUE
+"1557531_a_at",0.380084968057051,0.011815105757337,2.74340813310245,-2.81794773015214,2.4426422873908,"C10orf55","chromosome 10 open reading frame 55",TRUE
+"240235_at",0.978316880841318,0.895857403946136,0.132407087357591,-5.93114807271787,0.057393368121593,"C10orf62","chromosome 10 open reading frame 62",TRUE
+"1553843_at",0.772988605474261,0.283600135683772,-1.09892200889407,-5.36800976938225,-0.661388911573264,"C10orf67","chromosome 10 open reading frame 67",TRUE
+"1553845_x_at",0.904832003218088,0.610118429148941,0.517233624275733,-5.81021256780064,0.164830852348901,"C10orf67","chromosome 10 open reading frame 67",TRUE
+"1553844_a_at",0.984244246588495,0.923359484211971,-0.097304432451881,-5.93507294467875,-0.0679103045469338,"C10orf67","chromosome 10 open reading frame 67",TRUE
+"232456_at",0.973433731874338,0.871669468597783,0.163419662181098,-5.92668434452106,0.113064550685941,"C10orf71","chromosome 10 open reading frame 71",TRUE
+"237244_at",0.673622120503302,0.139903415794156,-1.53108064157194,-4.85817533621217,-1.36763383376871,"C10orf71-AS1","C10orf71 antisense RNA 1",TRUE
+"1568733_at",0.748760747870936,0.241847008423283,1.20254370155771,-5.2588601645278,0.418777968082503,"C10orf76","chromosome 10 open reading frame 76",TRUE
+"55662_at",0.89967769475675,0.59101501982495,0.545270270607625,-5.79589843084902,0.160499326882498,"C10orf76","chromosome 10 open reading frame 76",TRUE
+"218891_at",0.945498722604777,0.75387257711659,0.317452404260159,-5.8907180397736,0.124564769302998,"C10orf76","chromosome 10 open reading frame 76",TRUE
+"231609_at",0.966064677476069,0.841757412007604,-0.202003234286377,-5.91982824091892,-0.187290429948181,"C10orf82","chromosome 10 open reading frame 82",TRUE
+"222852_at",0.93565329131222,0.713464529714019,0.371948864022702,-5.8725239916314,0.12060452568441,"C10orf88","chromosome 10 open reading frame 88",TRUE
+"219240_s_at",0.962905928655899,0.831813063862624,-0.214897285126319,-5.91721549313411,-0.065433814039153,"C10orf88","chromosome 10 open reading frame 88",TRUE
+"1564198_a_at",0.46873451603839,0.0248105658786484,2.40776135530142,-3.45264756133231,1.34714972084066,"C10orf90","chromosome 10 open reading frame 90",TRUE
+"1562657_a_at",0.903678874758741,0.605196262975145,0.524416580513883,-5.80661536937579,0.21493240634336,"C10orf90","chromosome 10 open reading frame 90",TRUE
+"1556200_a_at",0.908882763411412,0.621479298131057,-0.50075847002131,-5.81828053650398,-0.455930610532809,"C10orf90","chromosome 10 open reading frame 90",TRUE
+"1553880_at",0.966593471043185,0.844683039780206,0.19821656371896,-5.92056496312454,0.0998105594655332,"C10orf91","chromosome 10 open reading frame 91",TRUE
+"220152_at",0.935094665155941,0.711396247566247,-0.37476792865703,-5.87150554838726,-0.181171113447425,"C10orf95","chromosome 10 open reading frame 95",TRUE
+"227735_s_at",0.868707627832565,0.504795794126537,0.677992665803813,-5.71823951600333,0.633039019659349,"C10orf99","chromosome 10 open reading frame 99",TRUE
+"227736_at",0.928596293858875,0.686184681563535,-0.409389291037599,-5.85837995478264,-0.303172944553847,"C10orf99","chromosome 10 open reading frame 99",TRUE
+"231538_at",0.508488499910913,0.0335264279307598,2.26647059733436,-3.70641379595645,0.904487707504079,"C11orf1","chromosome 11 open reading frame 1",TRUE
+"222785_x_at",0.67622507827427,0.142815243998868,1.51935461669748,-4.87383027234086,0.747914870259137,"C11orf1","chromosome 11 open reading frame 1",TRUE
+"231530_s_at",0.685268748888542,0.153861164359502,1.47657864126549,-4.93012094421187,0.725421732166099,"C11orf1","chromosome 11 open reading frame 1",TRUE
+"218925_s_at",0.969577323811311,0.854776574610142,-0.185174759846756,-5.92299602323832,-0.154660974561188,"C11orf1","chromosome 11 open reading frame 1",TRUE
+"220344_at",0.969642324744141,0.85516646078547,0.184671663449882,-5.92308650115237,0.0695498695899746,"C11orf16","chromosome 11 open reading frame 16",TRUE
+"220560_at",0.56861088242915,0.0582939958624998,1.9966494512841,-4.16468576134725,0.630702069824156,"C11orf21","chromosome 11 open reading frame 21",TRUE
+"1568978_s_at",0.969829083058377,0.855595048598043,0.184118683991303,-5.9231856671008,0.13462468710509,"C11orf21","chromosome 11 open reading frame 21",TRUE
+"218299_at",0.928203838544968,0.684430547506295,-0.41181667651091,-5.85741688111753,-0.17090978019935,"C11orf24","chromosome 11 open reading frame 24",TRUE
+"52164_at",0.948567563026335,0.765996221640112,-0.301298734326864,-5.89556390855594,-0.148757167729645,"C11orf24","chromosome 11 open reading frame 24",TRUE
+"228331_at",0.769258076576208,0.276163381135722,1.11651651047129,-5.35008800651256,0.469289178750596,"C11orf31","chromosome 11 open reading frame 31",TRUE
+"224677_x_at",0.851733415458562,0.456407215032563,0.758052735620357,-5.6636056496424,0.296636103642655,"C11orf31","chromosome 11 open reading frame 31",TRUE
+"231045_x_at",0.863559206655094,0.488483362815391,0.704463365180718,-5.70081755662112,0.193875512716962,"C11orf31","chromosome 11 open reading frame 31",TRUE
+"1557801_x_at",0.905336881291457,0.611075487282669,0.515840187794011,-5.81090479732482,0.191948726878071,"C11orf31","chromosome 11 open reading frame 31",TRUE
+"228332_s_at",0.948071428905202,0.764040663930883,0.303898697098092,-5.89480088766962,0.074369291798229,"C11orf31","chromosome 11 open reading frame 31",TRUE
+"1557799_at",0.994050962712312,0.972093855695221,-0.0353796088996492,-5.93907383407233,-0.0129782972592825,"C11orf31","chromosome 11 open reading frame 31",TRUE
+"1553086_at",0.919406408954167,0.657512266684612,0.449394584599689,-5.84179425111352,0.399436283310847,"C11orf40","chromosome 11 open reading frame 40",TRUE
+"1553895_at",0.99191600075981,0.962772329541145,-0.0472055339127741,-5.93859818584921,-0.0195637579244741,"C11orf42","chromosome 11 open reading frame 42",TRUE
+"1553417_at",0.697464915010884,0.168042164159824,1.42517493908944,-4.99604106623897,0.48992810467683,"C11orf44","chromosome 11 open reading frame 44",TRUE
+"1553787_at",0.637485146909712,0.108473690211377,1.67257766389599,-4.66188190119455,0.994020004790255,"C11orf45","chromosome 11 open reading frame 45",TRUE
+"203257_s_at",0.820536502908875,0.379843429427761,-0.896078726613943,-5.55598187632267,-0.416884244152781,"C11orf49","chromosome 11 open reading frame 49",TRUE
+"239789_at",0.96820875250691,0.850491797524321,0.190706950119904,-5.92198492215493,0.130673084139552,"C11orf49","chromosome 11 open reading frame 49",TRUE
+"1554188_at",0.990810941805126,0.954068484771435,0.058254023761267,-5.93803075193967,0.0245865853715932,"C11orf53","chromosome 11 open reading frame 53",TRUE
+"229851_s_at",0.747873265167012,0.239770836124601,-1.20803348727557,-5.25283801982222,-0.610259504453689,"C11orf54","chromosome 11 open reading frame 54",TRUE
+"223268_at",0.81304218438764,0.362356929266885,-0.93007241432169,-5.52691727380118,-0.463002462113687,"C11orf54","chromosome 11 open reading frame 54",TRUE
+"1559623_at",0.943824539742785,0.748620737357574,0.32447659603197,-5.88853271183944,0.101391051881015,"C11orf54","chromosome 11 open reading frame 54",TRUE
+"1555803_a_at",0.865326415663012,0.494632765774414,0.694426170525719,-5.707498605133,0.223988639669411,"C11orf57","chromosome 11 open reading frame 57",TRUE
+"1560029_a_at",0.898813992560978,0.58876990378761,0.548594042454818,-5.79415277915454,0.373478825942629,"C11orf57","chromosome 11 open reading frame 57",TRUE
+"222588_s_at",0.918373706340477,0.653387067781092,0.455210516034245,-5.83925678919985,0.170366891980294,"C11orf57","chromosome 11 open reading frame 57",TRUE
+"218314_s_at",0.958733377455711,0.812911214366151,0.239510898450515,-5.91178143569081,0.0708692585862831,"C11orf57","chromosome 11 open reading frame 57",TRUE
+"230724_s_at",0.96395433907282,0.835021589522943,0.210733077481835,-5.91807688944879,0.0632102331286735,"C11orf57","chromosome 11 open reading frame 57",TRUE
+"1560028_at",0.981158705865426,0.911149376275481,0.112870832553093,-5.93348028616146,0.036681941111735,"C11orf57","chromosome 11 open reading frame 57",TRUE
+"201784_s_at",0.757270745916058,0.253102251684866,-1.17338282045975,-5.29044823087567,-0.299560735030971,"C11orf58","chromosome 11 open reading frame 58",TRUE
+"1555365_x_at",0.793816937298172,0.325612683239272,1.00528527844744,-5.4590923380268,0.649549497394348,"C11orf58","chromosome 11 open reading frame 58",TRUE
+"225811_at",0.805670827550507,0.34508752838123,-0.964739848613775,-5.4962533735982,-0.388800085059103,"C11orf58","chromosome 11 open reading frame 58",TRUE
+"200084_at",0.885541558239607,0.547100288903076,-0.611487574765613,-5.75918509555647,-0.157813637507351,"C11orf58","chromosome 11 open reading frame 58",TRUE
+"1555364_at",0.919406408954167,0.657620918962785,0.449241614128859,-5.84186055954464,0.484001865015154,"C11orf58","chromosome 11 open reading frame 58",TRUE
+"1555787_at",0.744786425690684,0.236329212607365,1.21721323217189,-5.24271496878532,1.32990448988153,"C11orf63","chromosome 11 open reading frame 63",TRUE
+"220141_at",0.862779849418027,0.486426569306232,0.707836717061405,-5.69855163599996,0.885329189726328,"C11orf63","chromosome 11 open reading frame 63",TRUE
+"1552988_at",0.990810941805126,0.956287830190623,0.0554361803287901,-5.93818676375236,0.0337806481527698,"C11orf65","chromosome 11 open reading frame 65",TRUE
+"221534_at",0.963737076458538,0.834430530504006,0.211499899028971,-5.91791952753795,0.0864178946940299,"C11orf68","chromosome 11 open reading frame 68",TRUE
+"224463_s_at",0.725583196024696,0.20470120293896,1.30674328795732,-5.14054125560078,1.72460562442674,"C11orf70","chromosome 11 open reading frame 70",TRUE
+"241198_s_at",0.758722841981575,0.255882852214444,1.16632819340018,-5.29798826625727,1.01249019134643,"C11orf70","chromosome 11 open reading frame 70",TRUE
+"218789_s_at",0.44839970337033,0.0213098787828872,-2.47790899430092,-3.32350805952411,-0.980058028003796,"C11orf71","chromosome 11 open reading frame 71",TRUE
+"222743_s_at",0.70772084164277,0.179342723766801,-1.38665185414487,-5.04418626121271,-0.371881958043675,"C11orf71","chromosome 11 open reading frame 71",TRUE
+"1553438_at",0.894729774938685,0.57172294399404,0.574039809419416,-5.78044762338579,0.235496686756841,"C11orf72","chromosome 11 open reading frame 72",TRUE
+"228249_at",0.834110449220514,0.411967417846379,0.83620487712788,-5.60473079326068,0.375294330648558,"C11orf74","chromosome 11 open reading frame 74",TRUE
+"238593_at",0.580748061056528,0.0634519136211674,1.95389686057959,-4.23380372172361,1.21738318739204,"C11orf80","chromosome 11 open reading frame 80",TRUE
+"204922_at",0.74126098489332,0.231936926391384,1.22907661540365,-5.22953433427606,0.660924355169005,"C11orf80","chromosome 11 open reading frame 80",TRUE
+"227292_at",0.973071267819624,0.869766659071832,0.165865919312251,-5.92629251879728,0.0684237053746628,"C11orf84","chromosome 11 open reading frame 84",TRUE
+"233938_at",0.840041055449124,0.42905010497866,0.805573226657355,-5.62845314248595,0.536246697566126,"C11orf86","chromosome 11 open reading frame 86",TRUE
+"1557181_s_at",0.810921693906553,0.354950083938611,0.944801553271615,-5.51401480806954,0.637880342790756,"C11orf87","chromosome 11 open reading frame 87",TRUE
+"236532_at",0.902644664723856,0.601944711851788,-0.529176938161881,-5.80420478330577,-0.475045081211975,"C11orf87","chromosome 11 open reading frame 87",TRUE
+"1557180_at",0.973071267819624,0.870558468460527,-0.164847842001709,-5.92645629328487,-0.18799036796666,"C11orf87","chromosome 11 open reading frame 87",TRUE
+"1568606_at",0.648197684404188,0.11938232026329,1.61998521403086,-4.7364100485156,0.52064841845034,"C11orf88","chromosome 11 open reading frame 88",TRUE
+"240029_at",0.994304286761558,0.973930690975062,0.0330499384298628,-5.93915147646048,0.0175170717024216,"C11orf94","chromosome 11 open reading frame 94",TRUE
+"218641_at",0.878278790222455,0.531156643646929,-0.636211141871677,-5.744437444642,-0.333890286655034,"C11orf95","chromosome 11 open reading frame 95",TRUE
+"238152_at",0.970540753946729,0.859785902452572,-0.178714559856913,-5.92413918541335,-0.160965456691587,"C11orf95","chromosome 11 open reading frame 95",TRUE
+"1568616_a_at",0.699161781955613,0.170624886266735,1.41619205277044,-5.00736472278409,0.99578879529435,"C11orf96","chromosome 11 open reading frame 96",TRUE
+"227099_s_at",0.943824539742785,0.748491994484153,-0.324648993926532,-5.88847848106628,-0.268046547107921,"C11orf96","chromosome 11 open reading frame 96",TRUE
+"243803_at",0.55937703282623,0.0537165304601039,2.03750195485551,-4.09770489771761,0.982821984799172,"C11orf97","chromosome 11 open reading frame 97",TRUE
+"221637_s_at",0.82153774281298,0.384004967285471,-0.88814160534151,-5.56262407603963,-0.310876472824326,"C11orf98///LBHD1","chromosome 11 open reading frame 98///LBH domain containing 1",TRUE
+"218220_at",0.641880516735663,0.112245443447822,-1.65390931872105,-4.68854500903478,-0.554931154899975,"C12orf10","chromosome 12 open reading frame 10",TRUE
+"228378_at",0.875990189898743,0.524534620737444,0.64659742661819,-5.73807433482734,0.264590910284829,"C12orf29","chromosome 12 open reading frame 29",TRUE
+"213701_at",0.930899509890345,0.69430327700964,-0.398186957281993,-5.8627519074864,-0.179897536540883,"C12orf29","chromosome 12 open reading frame 29",TRUE
+"218374_s_at",0.96037751636593,0.820274832434723,0.229905001219182,-5.9139718623741,0.0913310013024162,"C12orf4","chromosome 12 open reading frame 4",TRUE
+"222613_at",0.96635324070119,0.843201865025504,-0.200133289529357,-5.92019378687673,-0.0972622202690587,"C12orf4","chromosome 12 open reading frame 4",TRUE
+"1553424_at",0.927693569185053,0.682785860403762,0.414094896479049,-5.85650789426694,0.330965203132422,"C12orf40","chromosome 12 open reading frame 40",TRUE
+"1561721_a_at",0.95915232180739,0.814864131975605,-0.236961094381837,-5.91237155901315,-0.223173499364177,"C12orf40","chromosome 12 open reading frame 40",TRUE
+"1561378_at",0.819479221404744,0.376833042241574,-0.901855979722067,-5.55111279258067,-0.40021109586364,"C12orf42","chromosome 12 open reading frame 42",TRUE
+"239977_at",0.997259934872759,0.985914792129442,-0.0178544257298983,-5.93952821570478,-0.00945416629031559,"C12orf42","chromosome 12 open reading frame 42",TRUE
+"219022_at",0.89657270599571,0.581237510840531,-0.559791429564177,-5.78819609399968,-0.153374475845274,"C12orf43","chromosome 12 open reading frame 43",TRUE
+"226349_at",0.909052380289506,0.622722864856554,-0.498963671513874,-5.81914406672135,-0.153472949806478,"C12orf45","chromosome 12 open reading frame 45",TRUE
+"234983_at",0.575115532641373,0.0606997733037887,-1.97630876085766,-4.19769674075387,-0.695767625086988,"C12orf49","chromosome 12 open reading frame 49",TRUE
+"218867_s_at",0.819780516863333,0.377445366885604,-0.900678408500285,-5.55210760005572,-0.222560934402415,"C12orf49","chromosome 12 open reading frame 49",TRUE
+"1558757_at",0.859276375962637,0.476249886854759,-0.724650479189527,-5.68710399126952,-0.668128966819625,"C12orf49","chromosome 12 open reading frame 49",TRUE
+"222767_s_at",0.943988850936011,0.749873320052178,-0.32279980153628,-5.88905868937307,-0.12002059157961,"C12orf49","chromosome 12 open reading frame 49",TRUE
+"1558758_s_at",0.969946179106301,0.85791805462284,0.181122475104115,-5.92371782362929,0.0773083481009254,"C12orf49","chromosome 12 open reading frame 49",TRUE
+"238219_at",0.869487815945782,0.506796327171442,0.674779928992627,-5.72031061216111,0.459830781873335,"C12orf50","chromosome 12 open reading frame 50",TRUE
+"240354_at",0.61760967235709,0.0879669043834443,-1.78495958003258,-4.49665329008741,-1.22800180875146,"C12orf54","chromosome 12 open reading frame 54",TRUE
+"237701_at",0.624331975868069,0.0957903309198286,1.73967906027741,-4.56418637351586,1.03026184748776,"C12orf54","chromosome 12 open reading frame 54",TRUE
+"240353_s_at",0.677013732819214,0.144377564215706,-1.51314375219137,-4.88208327367404,-1.06705792025005,"C12orf54","chromosome 12 open reading frame 54",TRUE
+"236840_at",0.402463840838386,0.014692684330985,2.64638483790711,-3.00558460648131,2.32793155502416,"C12orf56","chromosome 12 open reading frame 56",TRUE
+"224719_s_at",0.899808883319249,0.592734838708149,-0.54272836999033,-5.79722648571552,-0.217665129480157,"C12orf57","chromosome 12 open reading frame 57",TRUE
+"229888_at",0.786402837390602,0.311857088620083,1.03494917200331,-5.43102683947757,0.467834605549578,"C12orf60","chromosome 12 open reading frame 60",TRUE
+"243056_at",0.946257232656659,0.756461236116314,-0.313996152426525,-5.89177594399186,-0.142696991451458,"C12orf60","chromosome 12 open reading frame 60",TRUE
+"223476_s_at",0.864079461576774,0.491130643994786,0.70013357443018,-5.70371080598534,0.275905826159486,"C12orf65","chromosome 12 open reading frame 65",TRUE
+"223477_s_at",0.871165715950006,0.511755382692442,0.666846532817854,-5.72538454842645,0.239679442397126,"C12orf65","chromosome 12 open reading frame 65",TRUE
+"232650_at",0.897949253801113,0.586590760961325,0.55182613173188,-5.79244539794078,0.23697495808393,"C12orf65","chromosome 12 open reading frame 65",TRUE
+"1554067_at",0.519956259865057,0.0376264205154086,-2.2113725300198,-3.80292557992581,-0.990974556568599,"C12orf66","chromosome 12 open reading frame 66",TRUE
+"1554068_s_at",0.768852835478002,0.274143773065828,-1.12135410898418,-5.34511620869055,-0.646540934344273,"C12orf66","chromosome 12 open reading frame 66",TRUE
+"235026_at",0.885029460971826,0.545634809603902,-0.613743880682209,-5.75786256025389,-0.469152211462596,"C12orf66","chromosome 12 open reading frame 66",TRUE
+"226943_at",0.560923390313819,0.0545055431784242,-2.03024452730557,-4.10966974900177,-0.871073220806119,"C12orf73","chromosome 12 open reading frame 73",TRUE
+"226927_at",0.872540606821582,0.515843470976434,-0.660338696349674,-5.72950382048985,-0.178335770485981,"C12orf73","chromosome 12 open reading frame 73",TRUE
+"1556514_at",0.920564553801456,0.662282206828324,-0.44268921695999,-5.84468005054172,-0.237156145910796,"C12orf74","chromosome 12 open reading frame 74",TRUE
+"225105_at",0.821424121108148,0.383303434256886,0.889475645332304,-5.56151150715869,0.940697355962504,"C12orf75","chromosome 12 open reading frame 75",TRUE
+"1556299_s_at",0.614679164596232,0.085495166818525,1.79998651859563,-4.47396140509744,0.890576172053104,"C12orf76","chromosome 12 open reading frame 76",TRUE
+"226583_at",0.789495165970101,0.316317898596086,-1.02523078021452,-5.44030278167854,-0.353840500739965,"C12orf76","chromosome 12 open reading frame 76",TRUE
+"239691_at",0.552420073963858,0.0497718558752309,2.07527887883687,-4.03497300492654,1.45455370679685,"C12orf77","chromosome 12 open reading frame 77",TRUE
+"1560277_a_at",0.762857166457304,0.262662150923866,-1.14936374725326,-5.31595668770625,-0.667795825277015,"C12orf80","chromosome 12 open reading frame 80",TRUE
+"1560276_at",0.940668681806864,0.734471108088873,0.343485650886342,-5.88238141843458,0.301983871410468,"C12orf80","chromosome 12 open reading frame 80",TRUE
+"202562_s_at",0.7717895132349,0.281316639196886,-1.10428849412323,-5.36257025471575,-0.466043971557932,"C14orf1","chromosome 14 open reading frame 1",TRUE
+"217188_s_at",0.778265505991762,0.297702666564167,-1.0664519744762,-5.40041749356271,-0.368778154071455,"C14orf1","chromosome 14 open reading frame 1",TRUE
+"202563_at",0.973071267819624,0.869983176522248,0.165587511925992,-5.92633740511107,0.0654166176923177,"C14orf1","chromosome 14 open reading frame 1",TRUE
+"1569434_at",0.782206338814045,0.304050118442447,1.05219618978705,-5.41437107898717,0.884759001738511,"C14orf105","chromosome 14 open reading frame 105",TRUE
+"237328_at",0.788144775381206,0.314349213188018,-1.02950783431947,-5.43623017652346,-0.780185993270142,"C14orf105","chromosome 14 open reading frame 105",TRUE
+"220084_at",0.900774308374385,0.596479814077633,-0.537205737437657,-5.80009107754748,-0.574354943354859,"C14orf105","chromosome 14 open reading frame 105",TRUE
+"223060_at",0.9340157600858,0.707560995502863,-0.380003587172972,-5.86959393668325,-0.123067687165902,"C14orf119","chromosome 14 open reading frame 119",TRUE
+"231859_at",0.744307803443383,0.235184862369602,-1.22028788798359,-5.23930953013115,-2.29165391627368,"C14orf132","chromosome 14 open reading frame 132",TRUE
+"218820_at",0.808257777979515,0.3509012975387,-0.952940622398543,-5.50680537920041,-1.54516687177796,"C14orf132","chromosome 14 open reading frame 132",TRUE
+"1554039_at",0.791353982620776,0.321883436820879,1.01323944061132,-5.45163920725329,0.404290703218145,"C14orf159","chromosome 14 open reading frame 159",TRUE
+"218298_s_at",0.990810941805126,0.956129793837811,-0.0556368193665847,-5.93817591088152,-0.0613862796442053,"C14orf159","chromosome 14 open reading frame 159",TRUE
+"217768_at",0.828607509614823,0.398940663554752,-0.860108401396853,-5.58564468857974,-0.220653422989056,"C14orf166","chromosome 14 open reading frame 166",TRUE
+"219526_at",0.737123149977386,0.222969740852495,-1.25383681311841,-5.2016701893382,-0.474209983677232,"C14orf169","chromosome 14 open reading frame 169",TRUE
+"1564816_at",0.819018525257656,0.374544886183888,0.906267573249512,-5.54737521925921,0.256926981759958,"C14orf178","chromosome 14 open reading frame 178",TRUE
+"1558420_at",0.932091525948902,0.70066660544249,0.389442783589121,-5.86608149121584,0.155865180449984,"C14orf180","chromosome 14 open reading frame 180",TRUE
+"1558421_a_at",0.934081042629428,0.708403483352573,0.378852550490325,-5.8700164393524,0.16756528803025,"C14orf180","chromosome 14 open reading frame 180",TRUE
+"210532_s_at",0.308621629697291,0.0063274405327034,-3.01560693161049,-2.27635059236914,-0.887604395652392,"C14orf2","chromosome 14 open reading frame 2",TRUE
+"202279_at",0.766390367856479,0.266768901816558,-1.13924379059423,-5.32656529145724,-0.547110172559696,"C14orf2","chromosome 14 open reading frame 2",TRUE
+"235369_at",0.227168192678334,0.00284533562874779,-3.35458520727127,-1.57708229102483,-1.1778750231952,"C14orf28","chromosome 14 open reading frame 28",TRUE
+"238647_at",0.544577979658206,0.0465935175669748,-2.10772099633987,-3.98050483274314,-0.99198157592485,"C14orf28","chromosome 14 open reading frame 28",TRUE
+"1557176_a_at",0.937113154905832,0.720646752589158,-0.362183135133034,-5.87599336634434,-0.289969086945736,"C14orf37","chromosome 14 open reading frame 37",TRUE
+"1561985_at",0.914746370982129,0.640851420346904,0.472983283033915,-5.83130455356617,0.435467893473143,"C14orf39","chromosome 14 open reading frame 39",TRUE
+"213512_at",0.662575055303091,0.130308931107093,-1.57119696007562,-4.80389822979095,-0.806591481268595,"C14orf79","chromosome 14 open reading frame 79",TRUE
+"228558_at",0.855350972626085,0.467857817784283,-0.738674628019457,-5.67736035425674,-0.476944245760873,"C14orf80","chromosome 14 open reading frame 80",TRUE
+"219009_at",0.939647542340923,0.729324830821771,0.350431070923318,-5.88004754435367,0.139087952952341,"C14orf93","chromosome 14 open reading frame 93",TRUE
+"1553482_at",0.757619650696855,0.25377313731801,1.17167546959458,-5.29227670928415,0.529332749743043,"C15orf32","chromosome 15 open reading frame 32",TRUE
+"202399_s_at",0.768852835478002,0.27212403107184,-1.12621812487536,-5.34009808817851,-0.396304207901906,"C15orf38-AP3S2///AP3S2","C15orf38-AP3S2 readthrough///adaptor related protein complex 3 sigma 2 subunit",TRUE
+"202398_at",0.91608830456523,0.64604541101831,-0.465600917981526,-5.83464392747029,-0.189675704726239,"C15orf38-AP3S2///AP3S2","C15orf38-AP3S2 readthrough///adaptor related protein complex 3 sigma 2 subunit",TRUE
+"213215_at",0.932091525948902,0.699771239297819,-0.390671269088063,-5.86561810955594,-0.196368997741104,"C15orf38-AP3S2///AP3S2","C15orf38-AP3S2 readthrough///adaptor related protein complex 3 sigma 2 subunit",TRUE
+"204495_s_at",0.687545925823023,0.156463057567043,1.46686816486925,-4.94271892057323,0.726611584016437,"C15orf39","chromosome 15 open reading frame 39",TRUE
+"204494_s_at",0.792716268502624,0.324466344267402,1.00772353919104,-5.45681331929165,0.498698587025826,"C15orf39","chromosome 15 open reading frame 39",TRUE
+"215087_at",0.955925931146022,0.800947585175683,0.255167248319799,-5.90802030610008,0.117286636120033,"C15orf39","chromosome 15 open reading frame 39",TRUE
+"1552310_at",0.632216562924782,0.103292274720603,-1.69913946036807,-4.62355457756294,-0.562744515658663,"C15orf40","chromosome 15 open reading frame 40",TRUE
+"240201_at",0.652594853128465,0.12149543685404,1.61026745022737,-4.74998032871487,0.586354473643373,"C15orf40","chromosome 15 open reading frame 40",TRUE
+"224486_s_at",0.043795211728206,4.97414225011233e-05,5.01560266129571,1.98382426307362,1.67096235432784,"C15orf41","chromosome 15 open reading frame 41",TRUE
+"232506_s_at",0.0808717557112272,0.00027938240192155,4.30962466990196,0.468085839408091,2.08958897844659,"C15orf41","chromosome 15 open reading frame 41",TRUE
+"232507_at",0.502394860388381,0.03242709578986,2.28228926402637,-3.67844417062984,2.05951843195643,"C15orf41","chromosome 15 open reading frame 41",TRUE
+"223484_at",0.677013732819214,0.143877216412453,1.5151268196839,-4.87945110422068,2.91586427137501,"C15orf48","chromosome 15 open reading frame 48",TRUE
+"227272_at",0.557589172116298,0.052527490845959,2.04862055968464,-4.07931985614468,2.78218918232524,"C15orf52","chromosome 15 open reading frame 52",TRUE
+"1562367_at",0.700633137129073,0.172402452700359,1.4100726080773,-5.01504507944223,1.02997576422142,"C15orf54","chromosome 15 open reading frame 54",TRUE
+"239470_at",0.744573608322482,0.235709523301155,1.21887682076966,-5.24087332811814,0.949468258896136,"C15orf56","chromosome 15 open reading frame 56",TRUE
+"1558648_at",0.519634645385185,0.0374310345592632,2.21387116194459,-3.79857994301521,0.6916224247259,"C15orf57","chromosome 15 open reading frame 57",TRUE
+"225397_at",0.718706241731185,0.194708243354287,-1.33725061417786,-5.10432092001311,-0.457316575986866,"C15orf57","chromosome 15 open reading frame 57",TRUE
+"1560814_a_at",0.720999255123331,0.197119284235639,1.32977997981008,-5.11325564806874,1.3446427768884,"C15orf57","chromosome 15 open reading frame 57",TRUE
+"233482_at",0.79111001530823,0.321189942749192,-1.01472567709707,-5.45024069166642,-1.67473582782739,"C15orf59","chromosome 15 open reading frame 59",TRUE
+"230475_at",0.861659105448003,0.48317996985666,-0.713178297048246,-5.69494254482785,-0.568439365232735,"C15orf59","chromosome 15 open reading frame 59",TRUE
+"229742_at",0.567651250567208,0.0576217156574717,-2.00246660427852,-4.15520333509415,-0.73450439305617,"C15orf61","chromosome 15 open reading frame 61",TRUE
+"1569064_at",0.694505490882266,0.163809063120509,-1.44014059191091,-4.97704549349091,-1.18855939694968,"C15orf62","chromosome 15 open reading frame 62",TRUE
+"1569065_s_at",0.939166148226364,0.727568065754052,-0.352806013481337,-5.87923889759132,-0.22851837757954,"C15orf62","chromosome 15 open reading frame 62",TRUE
+"243309_at",0.927552865877291,0.682490920416025,-0.414503682701783,-5.85634427073677,-0.29552986051427,"C15orf65","chromosome 15 open reading frame 65",TRUE
+"1565641_at",0.888686718625571,0.555020423406414,0.59934822345653,-5.7662198970351,0.150428023876304,"C16orf45","chromosome 16 open reading frame 45",TRUE
+"212736_at",0.984515877561407,0.924449767332739,-0.0959157095204851,-5.93520357918662,-0.0852641378309347,"C16orf45","chromosome 16 open reading frame 45",TRUE
+"1553303_at",0.737123149977386,0.222604461508643,-1.25486140963701,-5.20050686141672,-0.915809848894574,"C16orf46","chromosome 16 open reading frame 46",TRUE
+"230281_at",0.954723352940649,0.794009218580815,0.264276922131793,-5.90572301238586,0.136270043403872,"C16orf46","chromosome 16 open reading frame 46",TRUE
+"244835_at",0.700511129947842,0.172298377535162,-1.41042950280038,-5.0145979015512,-0.852260754570569,"C16orf52","chromosome 16 open reading frame 52",TRUE
+"1559584_a_at",0.962555471240652,0.829487739463496,0.217917650368874,-5.91658020965116,0.301661054285147,"C16orf54","chromosome 16 open reading frame 54",TRUE
+"217891_at",0.366473876333673,0.0108136358502188,-2.78250686509705,-2.74147171107876,-0.934332871433346,"C16orf58","chromosome 16 open reading frame 58",TRUE
+"222190_s_at",0.497725944448536,0.0306345200112474,-2.30916807297876,-3.63065744175579,-0.894732463600514,"C16orf58","chromosome 16 open reading frame 58",TRUE
+"230074_s_at",0.961561244483099,0.826004851076694,-0.222445466895422,-5.91561132709237,-0.0786506578389039,"C16orf58","chromosome 16 open reading frame 58",TRUE
+"219556_at",0.713633547141264,0.18842290905676,-1.35707297670491,-5.08041046457222,-0.606155399092926,"C16orf59","chromosome 16 open reading frame 59",TRUE
+"1558557_at",0.904449064651725,0.608358825818598,0.519798244252433,-5.80893376289814,0.479596805245769,"C16orf62","chromosome 16 open reading frame 62",TRUE
+"203173_s_at",0.925511384407886,0.677374426233508,-0.42160665008428,-5.85347584564001,-0.336697306977259,"C16orf62","chromosome 16 open reading frame 62",TRUE
+"223440_at",0.822173415758858,0.386386648615568,-0.883624434256303,-5.56637983576154,-0.284688537554953,"C16orf70","chromosome 16 open reading frame 70",TRUE
+"220601_at",0.839519981963042,0.426597832529333,-0.809922960065595,-5.62513510218821,-0.431391769914519,"C16orf70","chromosome 16 open reading frame 70",TRUE
+"222089_s_at",0.789860910391852,0.318863581518592,1.01972776400254,-5.44552021746367,0.765703615682695,"C16orf71","chromosome 16 open reading frame 71",TRUE
+"225199_at",0.419170456955056,0.0171886147886815,-2.57578032341884,-3.14009609039471,-1.03124057536133,"C16orf72","chromosome 16 open reading frame 72",TRUE
+"1568954_s_at",0.562414216355319,0.0550048951852809,-2.02569966299277,-4.11714819452072,-0.567989585058196,"C16orf72","chromosome 16 open reading frame 72",TRUE
+"238011_at",0.580137756009815,0.062699543941249,-1.95993706056781,-4.22410016182738,-0.758459799031407,"C16orf72","chromosome 16 open reading frame 72",TRUE
+"225197_at",0.604824625238112,0.0788725788693198,-1.84218421253602,-4.40950621213078,-0.801731457509808,"C16orf72","chromosome 16 open reading frame 72",TRUE
+"228373_at",0.630603891142543,0.101540919278888,-1.70837347889079,-4.61012390115124,-0.515417662083324,"C16orf72","chromosome 16 open reading frame 72",TRUE
+"225183_at",0.671975073769862,0.137897765481442,-1.53927468897255,-4.84717906569469,-0.433180041777725,"C16orf72","chromosome 16 open reading frame 72",TRUE
+"220743_at",0.839026687117702,0.424738557769433,0.813231254738455,-5.62260026070746,0.498583859158414,"C16orf72","chromosome 16 open reading frame 72",TRUE
+"227806_at",0.823518986434235,0.390569400217964,0.875735034929129,-5.57289679699698,0.925427343714652,"C16orf74","chromosome 16 open reading frame 74",TRUE
+"240209_at",0.661902601432048,0.129152946424268,1.57619385258288,-4.7970601440403,0.598775201014668,"C16orf78","chromosome 16 open reading frame 78",TRUE
+"231076_at",0.748760747870936,0.241854786789867,1.20252320090951,-5.25888260853941,0.6851840049095,"C16orf82","chromosome 16 open reading frame 82",TRUE
+"231153_at",0.957430653957785,0.807702791151111,-0.24631921059958,-5.91017495592882,-0.0868445088800653,"C16orf86","chromosome 16 open reading frame 86",TRUE
+"226608_at",0.615637099066718,0.0860505820577253,-1.79657752431382,-4.47912138363645,-0.833087869179371,"C16orf87","chromosome 16 open reading frame 87",TRUE
+"242555_at",0.896229101808264,0.579464755520451,-0.562437240408799,-5.78677154172325,-0.460669156186598,"C16orf87","chromosome 16 open reading frame 87",TRUE
+"229177_at",0.851733415458562,0.456524660423266,-0.757852513268188,-5.66374949254195,-0.56690350036667,"C16orf89","chromosome 16 open reading frame 89",TRUE
+"225749_at",0.62524538993269,0.0964835316539191,-1.73582162889729,-4.56988025377622,-0.560571920868481,"C16orf91","chromosome 16 open reading frame 91",TRUE
+"1557162_at",0.872701172251,0.516964710870881,0.658558801306138,-5.73062369822866,0.389495092242372,"C16orf92","chromosome 16 open reading frame 92",TRUE
+"219785_s_at",0.627092759817312,0.0988200208981056,1.7229919169565,-4.58875033137676,1.4648563175793,"C16orf95","chromosome 16 open reading frame 95",TRUE
+"223745_at",0.679876113745083,0.147141536910527,1.5022893519134,-4.89644170695247,1.03172620883707,"C16orf95","chromosome 16 open reading frame 95",TRUE
+"219784_at",0.725583196024696,0.204608387343012,1.30702124603774,-5.14021443241345,0.515797322458852,"C16orf95","chromosome 16 open reading frame 95",TRUE
+"229071_at",0.591331966259927,0.0688163814336653,1.91257151191401,-4.29964010965153,0.821855268270665,"C17orf100","chromosome 17 open reading frame 100",TRUE
+"231453_at",0.733934891101761,0.218004390371482,1.26787601188964,-5.18565925044764,1.00448127446175,"C17orf105","chromosome 17 open reading frame 105",TRUE
+"1554662_at",0.92996437978379,0.690617208337599,-0.403266616849695,-5.86078425633707,-0.169521661423182,"C17orf47","chromosome 17 open reading frame 47",TRUE
+"237929_at",0.801587742916188,0.338714446977344,-0.977830964591001,-5.48440728747622,-0.56013226426779,"C17orf50","chromosome 17 open reading frame 50",TRUE
+"228146_at",0.405141741421442,0.0151386296794514,2.63298133869427,-3.03125595564567,2.90740080758525,"C17orf51","chromosome 17 open reading frame 51",TRUE
+"238166_s_at",0.499435312830389,0.031568381096443,2.2949906998917,-3.65590352879892,2.26996631184563,"C17orf51","chromosome 17 open reading frame 51",TRUE
+"1557346_a_at",0.738061563377262,0.224987420007135,1.24820029319981,-5.20805531289363,0.662439203106224,"C17orf51","chromosome 17 open reading frame 51",TRUE
+"238167_at",0.864079461576774,0.49116432322678,-0.700078576514799,-5.70374744724956,-0.382702614567109,"C17orf51","chromosome 17 open reading frame 51",TRUE
+"219879_s_at",0.789661545166663,0.317227124617507,1.02326175114824,-5.44217254208605,0.270919115697129,"C17orf53","chromosome 17 open reading frame 53",TRUE
+"226901_at",0.926430328514448,0.680265545525149,-0.417590370660317,-5.85510364649167,-0.226552315709634,"C17orf58","chromosome 17 open reading frame 58",TRUE
+"218130_at",0.801836064296888,0.339301176338462,-0.976618738303504,-5.48551034324182,-0.326623787559528,"C17orf62","chromosome 17 open reading frame 62",TRUE
+"1555985_at",0.872010957446544,0.514812116794041,-0.661977798973304,-5.72846996380972,-0.56124207513902,"C17orf64","chromosome 17 open reading frame 64",TRUE
+"236863_at",0.848475456105025,0.448763647745821,-0.771150971355869,-5.65411765838189,-0.436051099729164,"C17orf67","chromosome 17 open reading frame 67",TRUE
+"240082_s_at",0.825277018878999,0.39268986268113,0.871756436127363,-5.57616269774956,0.788343191673454,"C17orf74","chromosome 17 open reading frame 74",TRUE
+"203830_at",0.89565571257902,0.574956089622285,-0.569184737780452,-5.78310908229303,-0.240320284216086,"C17orf75","chromosome 17 open reading frame 75",TRUE
+"1553298_at",0.872670205591254,0.516834639730231,0.658765171010433,-5.73049400268868,0.609363999894522,"C17orf77","chromosome 17 open reading frame 77",TRUE
+"1553486_a_at",0.617775129514679,0.0887685483343681,1.78016413303493,-4.50386562059387,1.44087808800682,"C17orf78","chromosome 17 open reading frame 78",TRUE
+"223352_s_at",0.812302873476553,0.358413760389799,0.937888279877336,-5.5200938962556,0.251676781220805,"C17orf80","chromosome 17 open reading frame 80",TRUE
+"221048_x_at",0.955129558776714,0.79494868033764,-0.263042142318264,-5.9060390910823,-0.19151325068788,"C17orf80","chromosome 17 open reading frame 80",TRUE
+"223351_at",0.957620703212172,0.809989460160721,0.2433286915515,-5.91088610819581,0.0736086636359534,"C17orf80","chromosome 17 open reading frame 80",TRUE
+"1555478_at",0.897949253801113,0.58578176069269,-0.553027547762846,-5.79180825580441,-0.226614393096085,"C17orf82","chromosome 17 open reading frame 82",TRUE
+"225967_s_at",0.884749233889577,0.544177931376181,-0.61599013130822,-5.75654125362426,-0.239780835543707,"C17orf89","chromosome 17 open reading frame 89",TRUE
+"230199_at",0.959451355429682,0.81662837728503,0.234659008577792,-5.91289895452357,0.187508995450439,"C17orf89","chromosome 17 open reading frame 89",TRUE
+"225966_at",0.975398143273847,0.881120104103499,-0.151284704958008,-5.92854218103077,-0.0816572723865931,"C17orf89","chromosome 17 open reading frame 89",TRUE
+"228066_at",0.885694554133555,0.547489504386288,-0.610888862074243,-5.75953524271674,-0.44783079480306,"C17orf96","chromosome 17 open reading frame 96",TRUE
+"229238_at",0.753406724775675,0.246588264103534,-1.19013845422004,-5.27238053459672,-0.599725618697544,"C17orf97","chromosome 17 open reading frame 97",TRUE
+"244316_at",0.830635993561085,0.403644163898735,0.851420924033277,-5.59263934659036,0.569594756521016,"C17orf98","chromosome 17 open reading frame 98",TRUE
+"236981_at",0.523670563561336,0.0389723918268144,2.19447345751877,-3.83223785102144,1.03851349044647,"C17orf99","chromosome 17 open reading frame 99",TRUE
+"1553087_at",0.800053470634826,0.335445014099304,-0.984612390506424,-5.47821359331383,-0.583161940049408,"C18orf12","chromosome 18 open reading frame 12",TRUE
+"1553435_at",0.835952408568777,0.417086140117873,0.82694384960703,-5.61199031570576,0.486974892590332,"C18orf15","chromosome 18 open reading frame 15",TRUE
+"223526_at",0.635821858586292,0.106780045509779,-1.68113935933711,-4.64957766501216,-0.720336850132583,"C18orf21","chromosome 18 open reading frame 21",TRUE
+"1558990_at",0.893623865544737,0.569009990947864,0.578124505750085,-5.77819151008601,0.431254104612194,"C18orf21","chromosome 18 open reading frame 21",TRUE
+"226406_at",0.73223722457785,0.216296952491748,-1.27276037840696,-5.18005315016126,-0.470901838562106,"C18orf25","chromosome 18 open reading frame 25",TRUE
+"1553686_at",0.90427866743639,0.606784471062773,-0.522095860167691,-5.80778286210711,-0.140395059765145,"C18orf25","chromosome 18 open reading frame 25",TRUE
+"217508_s_at",0.916443520723728,0.647066953342822,-0.464152069515833,-5.83529326822538,-0.146812804389143,"C18orf25","chromosome 18 open reading frame 25",TRUE
+"217539_at",0.994057527155985,0.972262221621626,0.0351660611152251,-5.93908117117583,0.0152067873579682,"C18orf25","chromosome 18 open reading frame 25",TRUE
+"1553651_at",0.845588139978284,0.443119819956676,-0.780909437200885,-5.64694917699211,-0.705116193159426,"C18orf54","chromosome 18 open reading frame 54",TRUE
+"241733_at",0.89390639630277,0.569710133534575,-0.577069403489448,-5.77877576202263,-0.310663821145664,"C18orf54","chromosome 18 open reading frame 54",TRUE
+"229442_at",0.934081042629428,0.70824724478602,-0.379065969733491,-5.86993819656026,-0.170796925584936,"C18orf54","chromosome 18 open reading frame 54",TRUE
+"244324_at",0.964181293782946,0.835411700082731,-0.210227031026541,-5.91818042514342,-0.0935185082128811,"C18orf54","chromosome 18 open reading frame 54",TRUE
+"1553652_a_at",0.96882227301574,0.85286280705059,0.187644935030667,-5.92254822231854,0.122572612828843,"C18orf54","chromosome 18 open reading frame 54",TRUE
+"241943_at",0.163850812837738,0.00131859821945322,3.67422582049276,-0.900390504171001,1.64524772501573,"C18orf61","uncharacterized LOC497259",TRUE
+"243721_at",0.936992192746977,0.718153321379736,0.365569360639263,-5.87480069459085,0.211790208448867,"C18orf61","uncharacterized LOC497259",TRUE
+"221190_s_at",0.774209477315394,0.285979599521933,-1.0933631599135,-5.37361941232309,-0.351075709588843,"C18orf8","chromosome 18 open reading frame 8",TRUE
+"232345_at",0.778665768282906,0.299123813432705,-1.06324153284936,-5.4035745639456,-0.68260130386041,"C18orf8","chromosome 18 open reading frame 8",TRUE
+"232348_at",0.936019179681396,0.714165086412238,0.37099470336877,-5.872866982446,0.215514958802641,"C18orf8","chromosome 18 open reading frame 8",TRUE
+"227704_at",0.726636642789909,0.205783162634784,-1.30351030777304,-5.14433827068634,-1.12696950142916,"C19orf12","chromosome 19 open reading frame 12",TRUE
+"223983_s_at",0.885365229653684,0.546913333653719,0.611775239728086,-5.75901674182337,0.440056688823868,"C19orf12","chromosome 19 open reading frame 12",TRUE
+"225863_s_at",0.886782011834068,0.549901368471874,0.607183801928458,-5.76169472515586,0.3936392479602,"C19orf12","chromosome 19 open reading frame 12",TRUE
+"236847_at",0.62110896023334,0.0917680073969721,-1.76254563448466,-4.53024175291663,-1.37631963108131,"C19orf18","chromosome 19 open reading frame 18",TRUE
+"221587_s_at",0.851733415458562,0.455973997784463,-0.758791557620258,-5.66307455724734,-0.254045231535782,"C19orf24","chromosome 19 open reading frame 24",TRUE
+"226379_s_at",0.911649928037586,0.630043057719766,-0.488432027197757,-5.82415012897981,-0.201321958233096,"C19orf25","chromosome 19 open reading frame 25",TRUE
+"226378_s_at",0.943464796017993,0.747107228673696,0.326503951600304,-5.88789316779585,0.103913208641501,"C19orf25","chromosome 19 open reading frame 25",TRUE
+"223631_s_at",0.981836322577249,0.912983205236666,0.110531196550863,-5.93373471101122,0.166257741869295,"C19orf33","chromosome 19 open reading frame 33",TRUE
+"223003_at",0.819780516863333,0.377577009306595,0.900425409301852,-5.55232117597152,0.28458601509498,"C19orf43","chromosome 19 open reading frame 43",TRUE
+"230213_at",0.820611742812032,0.381095444019401,0.893684841134016,-5.55799096661962,0.388526097497516,"C19orf43","chromosome 19 open reading frame 43",TRUE
+"228154_at",0.695812999227098,0.165808753546792,-1.43303264639009,-4.98608768749788,-0.897460534527807,"C19orf44","chromosome 19 open reading frame 44",TRUE
+"232730_at",0.986421906591669,0.936630385219764,0.0804134113441653,-5.93653446699059,0.0385488207745333,"C19orf44","chromosome 19 open reading frame 44",TRUE
+"241862_x_at",0.776955214137673,0.295745692649333,1.0708908424827,-5.39603838417018,0.613036842176367,"C19orf45","chromosome 19 open reading frame 45",TRUE
+"241842_x_at",0.968066640321622,0.849920938803648,-0.191444457184206,-5.92184788976117,-0.115602721319465,"C19orf45","chromosome 19 open reading frame 45",TRUE
+"1554475_a_at",0.637485146909712,0.108512481880168,-1.6723828929844,-4.66216125742167,-1.43298249343443,"C19orf47","chromosome 19 open reading frame 47",TRUE
+"234999_at",0.744573608322482,0.235900054618103,-1.21836497774519,-5.24144018497375,-0.824920516121264,"C19orf47","chromosome 19 open reading frame 47",TRUE
+"231901_at",0.976120892129083,0.885215309156177,0.146033637310627,-5.9293017934266,0.058014351984573,"C19orf52","chromosome 19 open reading frame 52",TRUE
+"217926_at",0.88616634125539,0.548977414625721,0.608602147313457,-5.76086954443775,0.177282358817012,"C19orf53","chromosome 19 open reading frame 53",TRUE
+"222052_at",0.773234064853267,0.284594715660323,-1.09659440756737,-5.37036171946762,-0.425785999613804,"C19orf54","chromosome 19 open reading frame 54",TRUE
+"206901_at",0.632949074657601,0.103634458713767,-1.69735085266734,-4.62614974413313,-1.14984455394215,"C19orf57","chromosome 19 open reading frame 57",TRUE
+"51200_at",0.819018525257656,0.375128321884086,-0.905141015676911,-5.54833125888007,-0.276491924175481,"C19orf60","chromosome 19 open reading frame 60",TRUE
+"218958_at",0.877546037473893,0.528043792931141,-0.641084639793897,-5.74146404953502,-0.238033274050512,"C19orf60","chromosome 19 open reading frame 60",TRUE
+"218429_s_at",0.630603891142543,0.101907042183863,1.7064319622348,-4.61295232908911,1.00344036146591,"C19orf66","chromosome 19 open reading frame 66",TRUE
+"1555491_a_at",0.668193690220211,0.134274805340419,1.55432848859566,-4.82685611346985,0.988701771675528,"C19orf66","chromosome 19 open reading frame 66",TRUE
+"53720_at",0.686051458768383,0.154325503271922,1.47483597154305,-4.93238676004953,0.986238055808146,"C19orf66","chromosome 19 open reading frame 66",TRUE
+"238866_at",0.827337629605979,0.39612335560723,0.865343610982606,-5.58139768304304,0.630463335759229,"C19orf68","chromosome 19 open reading frame 68",TRUE
+"225823_at",0.870433264908839,0.508879340178052,-0.671442296373211,-5.72245225165454,-0.225680808684338,"C19orf70","chromosome 19 open reading frame 70",TRUE
+"220151_at",0.979588787486838,0.902003162815408,-0.124549667981802,-5.93213067891579,-0.0913372724009225,"C19orf73","chromosome 19 open reading frame 73",TRUE
+"230814_at",0.839466826665106,0.425934660673261,-0.8111019389295,-5.624232871163,-0.750293982952088,"C19orf81","chromosome 19 open reading frame 81",TRUE
+"1560830_a_at",0.98539961718117,0.928740890492647,-0.0904518402644316,-5.9356993420197,-0.0246867209157688,"C19orf84","chromosome 19 open reading frame 84",TRUE
+"200056_s_at",0.936143408699214,0.71474501309455,0.370205106581061,-5.87315016030718,0.105067338462563,"C1D","C1D nuclear receptor corepressor",TRUE
+"226105_at",0.632949074657601,0.103950812120381,1.6957017182989,-4.62854072065145,1.04344148402548,"C1GALT1","core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1",TRUE
+"219439_at",0.678455276397227,0.145929785840335,1.50702730899086,-4.89018440779348,0.921826647136166,"C1GALT1","core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1",TRUE
+"226107_at",0.69450946988669,0.16395795582013,1.43960895030159,-4.97772307217847,1.07230856697063,"C1GALT1","core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1",TRUE
+"238989_at",0.682539393883246,0.15016038334485,1.49062273339301,-4.9117821156479,0.672589065885703,"C1GALT1C1","C1GALT1 specific chaperone 1",TRUE
+"219283_at",0.968482638277755,0.852240269597856,0.188448725487487,-5.92240123344722,0.0922551484053944,"C1GALT1C1","C1GALT1 specific chaperone 1",TRUE
+"241710_at",0.73957587762701,0.227704041344258,1.24067185986373,-5.21654504922185,1.66064552438769,"C1GALT1C1L","C1GALT1-specific chaperone 1 like",TRUE
+"237603_at",0.406049718268978,0.0152706588270767,2.62908424963327,-3.03870817453228,1.37122692013784,"C1orf100","chromosome 1 open reading frame 100",TRUE
+"233578_at",0.62110896023334,0.0917835557509134,1.76245560242746,-4.53037604274562,0.572304515326084,"C1orf101","chromosome 1 open reading frame 101",TRUE
+"240771_at",0.892746695408886,0.565466829110887,-0.583474196849105,-5.77521327593931,-0.500555582382214,"C1orf101","chromosome 1 open reading frame 101",TRUE
+"214357_at",0.948109877411639,0.764223379582694,-0.303655681786769,-5.89487248159058,-0.135762055240888,"C1orf105","chromosome 1 open reading frame 105",TRUE
+"219010_at",0.758349492775124,0.255313628987389,1.16776770738964,-5.29645293622339,1.36979902342808,"C1orf106","chromosome 1 open reading frame 106",TRUE
+"218712_at",0.425751189365875,0.0181761665696172,-2.55047438952704,-3.18786770183744,-0.845889353787863,"C1orf109","chromosome 1 open reading frame 109",TRUE
+"231163_at",0.925511384407886,0.678285160918592,-0.42034071968603,-5.85399058129086,-0.285284948189288,"C1orf111","chromosome 1 open reading frame 111",TRUE
+"220840_s_at",0.819018525257656,0.374033344476891,0.907256265041061,-5.54653527300228,0.243453088643925,"C1orf112","chromosome 1 open reading frame 112",TRUE
+"230159_at",0.620223198657182,0.0900357009103181,1.77265950667757,-4.51512407459187,1.02246959133567,"C1orf115","chromosome 1 open reading frame 115",TRUE
+"218546_at",0.95018792835023,0.773418483038083,-0.291449747557091,-5.89839537555283,-0.303196046841016,"C1orf115","chromosome 1 open reading frame 115",TRUE
+"219856_at",0.308861881799719,0.00643002623315933,3.00868943637573,-2.29036131071084,4.80467528362668,"C1orf116","chromosome 1 open reading frame 116",TRUE
+"219476_at",0.384586587899771,0.0125708518659214,2.71592899055294,-2.87140603693525,4.05529505363744,"C1orf116","chromosome 1 open reading frame 116",TRUE
+"228865_at",0.403035132901446,0.0149288918269853,2.63923836086561,-3.01927983746856,3.66747382292358,"C1orf116","chromosome 1 open reading frame 116",TRUE
+"225480_at",0.134365850976746,0.000855222974666806,-3.85235224174508,-0.518647415237335,-1.08903116663176,"C1orf122","chromosome 1 open reading frame 122",TRUE
+"203197_s_at",0.98539961718117,0.928387529120532,-0.0909016649311713,-5.93565962447509,-0.0365240869379058,"C1orf123","chromosome 1 open reading frame 123",TRUE
+"1553444_a_at",0.93565329131222,0.713275405551692,0.372206512054207,-5.87243122618472,0.158632560812582,"C1orf127","chromosome 1 open reading frame 127",TRUE
+"226242_at",0.632949074657601,0.103601871323569,-1.69752097183379,-4.62590299951395,-0.723756052325372,"C1orf131","chromosome 1 open reading frame 131",TRUE
+"1560554_a_at",0.787211643646529,0.313023734472613,-1.03239810736487,-5.43346940179092,-0.518355126972569,"C1orf145","chromosome 1 open reading frame 145",TRUE
+"1560130_at",0.896115372949367,0.577578545740004,-0.565256842709319,-5.78524624655716,-0.462139740329645,"C1orf145","chromosome 1 open reading frame 145",TRUE
+"231549_at",0.705650323866416,0.1777320465835,1.39202208215967,-5.03754002360588,0.781724081120354,"C1orf158","chromosome 1 open reading frame 158",TRUE
+"219337_at",0.796466121438385,0.329113413932488,0.997875939862876,-5.46598704287844,0.261563812036437,"C1orf159","chromosome 1 open reading frame 159",TRUE
+"228532_at",0.921312278448293,0.664713259141862,-0.439279688365306,-5.84613108860678,-0.243124057685574,"C1orf162","chromosome 1 open reading frame 162",TRUE
+"1561976_at",0.466373536852322,0.0244037856908218,2.41542337872614,-3.43864006341379,0.622214868535224,"C1orf167","chromosome 1 open reading frame 167",TRUE
+"238625_at",0.40129202983775,0.0143653927717631,-2.6564679186708,-2.98623174456284,-3.07516252081461,"C1orf168","chromosome 1 open reading frame 168",TRUE
+"231073_at",0.601603171821172,0.0769127786196615,-1.85526139901996,-4.38931456846305,-1.33487035695985,"C1orf168","chromosome 1 open reading frame 168",TRUE
+"238010_at",0.792013951867008,0.322843855520967,1.01118483863445,-5.45356948632992,0.405167426873502,"C1orf174","chromosome 1 open reading frame 174",TRUE
+"222000_at",0.875435508930713,0.52277455639859,0.649370024770964,-5.73635897844284,0.222173556105403,"C1orf174","chromosome 1 open reading frame 174",TRUE
+"231044_at",0.919095054289206,0.655541093840338,0.452171675815419,-5.84058661072807,0.274956282289803,"C1orf194","chromosome 1 open reading frame 194",TRUE
+"223063_at",0.797856706388872,0.33175880704948,-0.992313076315666,-5.47113308445998,-0.443981584633288,"C1orf198","chromosome 1 open reading frame 198",TRUE
+"1556633_at",0.588467901034655,0.0671179906269158,1.92533885197297,-4.27940377549205,0.830326115882025,"C1orf204","chromosome 1 open reading frame 204",TRUE
+"223127_s_at",0.736223289546449,0.221695111826113,1.25741770478372,-5.1976008889109,0.760092661392672,"C1orf21","chromosome 1 open reading frame 21",TRUE
+"223126_s_at",0.774641130415354,0.291050895831532,-1.08162615257527,-5.38538039486137,-0.632519776581854,"C1orf21","chromosome 1 open reading frame 21",TRUE
+"237098_at",0.819018525257656,0.373300050821151,-0.908675112863827,-5.54532840892157,-0.316402127875545,"C1orf21","chromosome 1 open reading frame 21",TRUE
+"221272_s_at",0.955904644595647,0.800285184447856,0.256035977675451,-5.90780468182401,0.186091771927917,"C1orf21","chromosome 1 open reading frame 21",TRUE
+"223125_s_at",0.974894716756856,0.87746765260762,-0.155971725493483,-5.92784155030067,-0.128516583605393,"C1orf21","chromosome 1 open reading frame 21",TRUE
+"1554246_at",0.96287357728432,0.831530357403009,-0.215264382982212,-5.91713875143291,-0.210917262432629,"C1orf210","chromosome 1 open reading frame 210",TRUE
+"212791_at",0.89085645983207,0.559862338906419,-0.591971527820704,-5.7704281653817,-0.191869159463836,"C1orf216","chromosome 1 open reading frame 216",TRUE
+"1563876_at",0.847832042863797,0.447474900998693,0.773372672061537,-5.65249309500085,0.749897059137417,"C1orf220","chromosome 1 open reading frame 220",TRUE
+"227019_at",0.757950630724418,0.254175904835316,-1.17065207083215,-5.29337159614031,-0.828379420796031,"C1orf226","chromosome 1 open reading frame 226",TRUE
+"242520_s_at",0.696169403206575,0.166261462741634,1.43143305950508,-4.98811751965829,0.946028947378124,"C1orf228","chromosome 1 open reading frame 228",TRUE
+"238365_s_at",0.806341956816164,0.347261428477215,0.960312148122547,-5.50022697087529,0.666708708437901,"C1orf228","chromosome 1 open reading frame 228",TRUE
+"239844_x_at",0.947926063538122,0.762854686485559,0.305476524715647,-5.89433466848909,0.165203137218858,"C1orf228","chromosome 1 open reading frame 228",TRUE
+"238366_at",0.951339758531576,0.777455838641925,-0.286104766546779,-5.89989292689313,-0.209682669120372,"C1orf228","chromosome 1 open reading frame 228",TRUE
+"238367_s_at",0.974884920935236,0.87705308922713,0.15650393944608,-5.92776064499462,0.07892714402018,"C1orf228","chromosome 1 open reading frame 228",TRUE
+"231551_at",0.835952408568777,0.415783633899748,-0.829293561843295,-5.61015558596498,-0.513266094240326,"C1orf234","chromosome 1 open reading frame 234",TRUE
+"222720_x_at",0.72050514215489,0.196567382054689,-1.33148371342438,-5.11122172147099,-0.512956788655994,"C1orf27","chromosome 1 open reading frame 27",TRUE
+"218721_s_at",0.801086839730802,0.337120058891864,-0.981132383193786,-5.48139686604469,-0.371236582494358,"C1orf27","chromosome 1 open reading frame 27",TRUE
+"219063_at",0.901788521024914,0.599172009976603,-0.533246043218614,-5.8021274330183,-0.167914136710946,"C1orf35","chromosome 1 open reading frame 35",TRUE
+"1555226_s_at",0.48580305784244,0.0284395777549832,-2.3441187533354,-3.56803693801148,-0.829987105483909,"C1orf43","chromosome 1 open reading frame 43",TRUE
+"223034_s_at",0.519299028471265,0.0373648354459251,-2.21472041800157,-3.79710223172675,-0.720427058355671,"C1orf43","chromosome 1 open reading frame 43",TRUE
+"1555225_at",0.769258076576208,0.276295869150516,-1.11620006278834,-5.35041256936543,-0.500655966276504,"C1orf43","chromosome 1 open reading frame 43",TRUE
+"219406_at",0.686108994812404,0.154462653979749,-1.47432205781549,-4.93305453694692,-0.456948410305911,"C1orf50","chromosome 1 open reading frame 50",TRUE
+"239038_at",0.682825347106105,0.150843652995824,-1.4880087498393,-4.91520605470016,-0.491614004280027,"C1orf52","chromosome 1 open reading frame 52",TRUE
+"228135_at",0.878218253751206,0.530239831268058,-0.637644893195817,-5.7435649559783,-0.167102248474466,"C1orf52","chromosome 1 open reading frame 52",TRUE
+"1558507_at",0.565795244949651,0.0567055463189465,-2.01049192284585,-4.14209114605576,-1.63263313036932,"C1orf53","chromosome 1 open reading frame 53",TRUE
+"1558508_a_at",0.822850703882235,0.388215470265302,-0.880168151619024,-5.56924153830229,-0.440216981686611,"C1orf53","chromosome 1 open reading frame 53",TRUE
+"219506_at",0.994039532642026,0.97184067997891,-0.0357007287924467,-5.93906271738199,-0.0199424874601162,"C1orf54","chromosome 1 open reading frame 54",TRUE
+"221222_s_at",0.702630084418366,0.174272083849548,-1.40369039994564,-5.02302604443617,-0.85544319872562,"C1orf56","chromosome 1 open reading frame 56",TRUE
+"230468_s_at",0.707596006786505,0.179044902520524,-1.38764193534726,-5.04296252831503,-0.799777879209173,"C1orf56","chromosome 1 open reading frame 56",TRUE
+"223459_s_at",0.83516820266233,0.414119880255247,-0.832301730071585,-5.6077996048971,-0.394334361800361,"C1orf56","chromosome 1 open reading frame 56",TRUE
+"205103_at",0.190498595861526,0.00194312585783339,3.51370800071204,-1.24184168806241,1.23509139380012,"C1orf61","chromosome 1 open reading frame 61",TRUE
+"222301_at",0.407657791010738,0.0155085177010029,2.62214265970732,-3.0519690280915,0.605172780155481,"C1orf61","chromosome 1 open reading frame 61",TRUE
+"1559402_a_at",0.78809916745704,0.31423201524268,1.02976304460058,-5.43598668193332,0.578140011325734,"C1orf61","chromosome 1 open reading frame 61",TRUE
+"1570451_at",0.998870448604467,0.996350838659961,-0.00462544151708404,-5.93967306018043,-0.00179431453084034,"C1orf61","chromosome 1 open reading frame 61",TRUE
+"229381_at",0.582527497755585,0.0643482925125766,-1.94678250232964,-4.24520666189105,-2.31302747820624,"C1orf64","chromosome 1 open reading frame 64",TRUE
+"216701_at",0.681732274610686,0.14932412594726,1.49383522625297,-4.90756759874534,0.887594082139012,"C1orf68","chromosome 1 open reading frame 68",TRUE
+"217087_at",0.932742319779223,0.703015605958519,-0.386222733659241,-5.86728925982521,-0.243650776286773,"C1orf68","chromosome 1 open reading frame 68",TRUE
+"229933_at",0.948429371744093,0.765379438306744,0.302118533449704,-5.89532402048537,0.129787036949924,"C1orf74","chromosome 1 open reading frame 74",TRUE
+"231932_at",0.990623482682449,0.952564384013439,-0.0601640136087433,-5.93792060795692,-0.0221255694858309,"C1orf74","chromosome 1 open reading frame 74",TRUE
+"236710_at",0.522667179791589,0.0383772911947438,2.20187869772432,-3.81941002275311,1.47971651588253,"C1orf87","chromosome 1 open reading frame 87",TRUE
+"231514_at",0.863739823286196,0.489339655058609,-0.703061372822831,-5.70175625659294,-0.330534894148926,"C1orf94","chromosome 1 open reading frame 94",TRUE
+"218232_at",0.527826453640453,0.0403837013964978,2.17731353014289,-3.86186113397392,1.23342744634943,"C1QA","complement C1q A chain",TRUE
+"202953_at",0.906476756086155,0.613534644306812,0.512264488178758,-5.81267279992097,0.255880941163788,"C1QB","complement C1q B chain",TRUE
+"214214_s_at",0.68865058167867,0.157861263835221,1.46170391343308,-4.9493913901142,0.513200194010086,"C1QBP","complement C1q binding protein",TRUE
+"208910_s_at",0.69536100382196,0.164813593937426,1.43656129038105,-4.98160338064908,0.518037126486565,"C1QBP","complement C1q binding protein",TRUE
+"225353_s_at",0.972819824894874,0.868413824008485,0.167605757258463,-5.92601030945242,0.125337049411181,"C1QC","complement C1q C chain",TRUE
+"214346_at",0.839466826665106,0.425543013247583,-0.811798742696531,-5.62369905279952,-0.275438242373172,"C1QL1","complement C1q like 1",TRUE
+"205575_at",0.93763407082406,0.724141612142277,-0.357444153023686,-5.8776440931075,-0.14990249064284,"C1QL1","complement C1q like 1",TRUE
+"224197_s_at",0.296090407530139,0.00528735027289204,3.09255942640356,-2.11972140841292,1.28017165983886,"C1QTNF1","C1q and tumor necrosis factor related protein 1",TRUE
+"220975_s_at",0.3055636726201,0.00607655354551995,3.03298949972187,-2.24109245120261,1.69506482150047,"C1QTNF1","C1q and tumor necrosis factor related protein 1",TRUE
+"237313_at",0.0592928515268338,0.000121903277991042,4.64810153798921,1.19802866785983,2.27857310898268,"C1QTNF1-AS1","C1QTNF1 antisense RNA 1",TRUE
+"223749_at",0.852153111602676,0.457802227453275,0.755676496758911,-5.66531045875449,0.896425123119903,"C1QTNF2","C1q and tumor necrosis factor related protein 2",TRUE
+"1561263_at",0.819193107051406,0.375644902764007,0.904144513762514,-5.54917601277507,0.429420697746185,"C1QTNF3","C1q and tumor necrosis factor related protein 3",TRUE
+"220988_s_at",0.822010986888098,0.385801877208425,-0.884731841811382,-5.56546073448269,-0.283966088703798,"C1QTNF3","C1q and tumor necrosis factor related protein 3",TRUE
+"209424_s_at",0.895213601869362,0.573310403620777,-0.571654257408514,-5.78175807518213,-0.261742326704578,"C1QTNF3-AMACR///AMACR","C1QTNF3-AMACR readthrough (NMD candidate)///alpha-methylacyl-CoA racemase",TRUE
+"209425_at",0.921312278448293,0.664787061644835,-0.439176263939927,-5.84617493223234,-0.212655707657426,"C1QTNF3-AMACR///AMACR","C1QTNF3-AMACR readthrough (NMD candidate)///alpha-methylacyl-CoA racemase",TRUE
+"209426_s_at",0.965883239653478,0.840195628677565,0.204025900912153,-5.91942902784181,0.0799772057742221,"C1QTNF3-AMACR///AMACR","C1QTNF3-AMACR readthrough (NMD candidate)///alpha-methylacyl-CoA racemase",TRUE
+"223708_at",0.754491163266461,0.247745736470606,-1.18713717780825,-5.27563325761361,-0.577239571192986,"C1QTNF4","C1q and tumor necrosis factor related protein 4",TRUE
+"224286_at",0.868397087637799,0.50378213497348,0.679623279109058,-5.71718473844361,0.244013204997754,"C1QTNF5///MFRP","C1q and tumor necrosis factor related protein 5///membrane frizzled-related protein",TRUE
+"223499_at",0.94895689004559,0.769391856272897,0.296789173186955,-5.89687193356765,0.153882275672704,"C1QTNF5///MFRP","C1q and tumor necrosis factor related protein 5///membrane frizzled-related protein",TRUE
+"223571_at",0.743323328391634,0.233580943851791,1.22461642677329,-5.23450272042089,1.77362440997593,"C1QTNF6","C1q and tumor necrosis factor related protein 6",TRUE
+"242444_at",0.778686132916778,0.299611840986452,1.06214156462231,-5.40465428452351,0.74253111074011,"C1QTNF6","C1q and tumor necrosis factor related protein 6",TRUE
+"223877_at",0.766550448794594,0.267681368695294,-1.13701085410786,-5.32889491417196,-0.723027854360417,"C1QTNF7","C1q and tumor necrosis factor related protein 7",TRUE
+"239349_at",0.962741248200658,0.830457339298429,-0.216657986189911,-5.91684623197245,-0.179352828318814,"C1QTNF7","C1q and tumor necrosis factor related protein 7",TRUE
+"222277_at",0.766390367856479,0.266900867507877,-1.13892050487829,-5.32690282490026,-0.62148992110999,"C1QTNF9B-AS1","C1QTNF9B antisense RNA 1",TRUE
+"1554233_at",0.812302873476553,0.357249947740467,-0.940206136318617,-5.51806028812625,-0.626078248023702,"C1QTNF9B///C1QTNF9","C1q and tumor necrosis factor related protein 9B///C1q and tumor necrosis factor related protein 9",TRUE
+"212067_s_at",0.641880516735663,0.11223585716482,1.65395609094839,-4.68847849156812,1.22009506816046,"C1R","complement C1r subcomponent",TRUE
+"218983_at",0.771527793162888,0.280795718956229,1.10551713873005,-5.36132157845099,1.61107143238175,"C1RL","complement C1r subcomponent like",TRUE
+"233645_s_at",0.931582451098271,0.698223876464007,0.392795770328205,-5.86481335925048,0.355263710172852,"C1RL","complement C1r subcomponent like",TRUE
+"1564224_x_at",0.748438284778152,0.241063888745575,1.20461023370463,-5.25659603007015,0.48175668322377,"C1RL-AS1","C1RL antisense RNA 1",TRUE
+"1560320_a_at",0.992984076039555,0.966540823827144,0.0424238311740054,-5.93880691158081,0.0326156277767877,"C1RL-AS1","C1RL antisense RNA 1",TRUE
+"1555229_a_at",0.644844656970274,0.115163348375676,1.63982648059965,-4.70850754960097,2.58498590420677,"C1S","complement component 1, s subcomponent",TRUE
+"208747_s_at",0.662015916975184,0.129991790979104,1.57256416703341,-4.80202894289962,2.60942567716936,"C1S","complement component 1, s subcomponent",TRUE
+"203052_at",0.799008022536007,0.333557487591749,-0.988548204754541,-5.47460101938744,-0.720987638085408,"C2","complement component 2",TRUE
+"1554533_at",0.923758661165355,0.672606981773233,-0.428244949834257,-5.8507517662501,-0.184230074645042,"C2","complement component 2",TRUE
+"231360_at",0.937113154905832,0.719485058147338,0.363760244913339,-5.87543925153132,0.15462508403781,"C20orf141","chromosome 20 open reading frame 141",TRUE
+"231522_at",0.883114005048829,0.540862508203758,0.62111388514117,-5.75350991151145,0.383989064264406,"C20orf144","chromosome 20 open reading frame 144",TRUE
+"1553205_at",0.812302873476553,0.357822822276116,0.939064562147572,-5.51906244224086,0.261269710258723,"C20orf166-AS1","C20orf166 antisense RNA 1",TRUE
+"1553204_at",0.997623421895415,0.988226511748618,-0.014923837572357,-5.93957500217898,-0.00749628841654637,"C20orf166-AS1","C20orf166 antisense RNA 1",TRUE
+"233143_at",0.79115933526522,0.321238907048704,1.01462066760339,-5.45033956417605,0.399108122231969,"C20orf173","chromosome 20 open reading frame 173",TRUE
+"1567036_at",0.869971289491322,0.508038543568815,0.672788589175062,-5.72158960681438,0.225722741137337,"C20orf181","chromosome 20 open reading frame 181",TRUE
+"1567035_at",0.964685626382167,0.836441257083866,0.208891772020883,-5.91845242551946,0.0593590172702338,"C20orf181","chromosome 20 open reading frame 181",TRUE
+"233598_at",0.868397087637799,0.503366876144017,0.680291815649822,-5.71675158890503,0.343125488368327,"C20orf187","chromosome 20 open reading frame 187",TRUE
+"225825_at",0.851319596585235,0.455037249756121,0.760390560983492,-5.66192345948115,0.387018527418032,"C20orf194","chromosome 20 open reading frame 194",TRUE
+"226607_at",0.985425981490741,0.929067004917873,0.0900367175928265,-5.93573582085268,0.0500927279894299,"C20orf194","chromosome 20 open reading frame 194",TRUE
+"235064_s_at",0.51470556386048,0.0349667318969206,-2.24644778621846,-3.74165124466408,-1.79672746794376,"C20orf196","chromosome 20 open reading frame 196",TRUE
+"243508_at",0.853650647295844,0.46229263330835,0.748056943052619,-5.67074285853081,0.544625644983489,"C20orf196","chromosome 20 open reading frame 196",TRUE
+"243507_s_at",0.88113080359582,0.537142773852412,0.626882489795039,-5.75006811514223,0.285041524963292,"C20orf196","chromosome 20 open reading frame 196",TRUE
+"235063_at",0.948109877411639,0.764221241214642,-0.303658525749209,-5.89487164406868,-0.273357114949365,"C20orf196","chromosome 20 open reading frame 196",TRUE
+"1553311_at",0.765671638296866,0.26592888767626,-1.14130439436172,-5.32441188967791,-0.957178748826814,"C20orf197","chromosome 20 open reading frame 197",TRUE
+"1563068_at",0.897024165042344,0.58304649166562,0.557095709233251,-5.78964081548319,0.338941965043586,"C20orf197","chromosome 20 open reading frame 197",TRUE
+"1556266_a_at",0.742608345161152,0.232930912893139,-1.22637709506209,-5.23254330369462,-0.754269999814789,"C20orf202","chromosome 20 open reading frame 202",TRUE
+"1556265_at",0.867259912702635,0.499466973087338,-0.686585652113276,-5.71265381187144,-0.264956061424615,"C20orf202","chromosome 20 open reading frame 202",TRUE
+"1556722_a_at",0.765934384067577,0.266167278357865,1.14071912212011,-5.32502386794287,0.372822527179593,"C20orf203","chromosome 20 open reading frame 203",TRUE
+"1556721_at",0.820288124919738,0.378515587093464,0.898623269066172,-5.55384089500172,0.407850709310293,"C20orf203","chromosome 20 open reading frame 203",TRUE
+"218081_at",0.951206799139251,0.776945164534374,0.286780365354156,-5.8997051564827,0.151311031221804,"C20orf27","chromosome 20 open reading frame 27",TRUE
+"50314_i_at",0.982243328340126,0.914327372334174,0.108816683099283,-5.93391777708059,0.057257412468779,"C20orf27","chromosome 20 open reading frame 27",TRUE
+"237793_at",0.655745626967443,0.124299303805875,1.59758877232981,-4.76759014416947,1.03574734715945,"C20orf78","chromosome 20 open reading frame 78",TRUE
+"229542_at",0.974871801904735,0.87676111117266,0.156878806869268,-5.92770349392481,0.111504012747196,"C20orf85","chromosome 20 open reading frame 85",TRUE
+"231905_at",0.411110107932987,0.0162064836817689,2.60233608483086,-3.08971259979617,1.62662649457767,"C20orf96","chromosome 20 open reading frame 96",TRUE
+"221975_s_at",0.522667179791589,0.0384846448205718,-2.20053515328246,-3.82173936114268,-1.72085645344895,"C21orf2","chromosome 21 open reading frame 2",TRUE
+"238582_at",0.573496623084053,0.0602706598170201,-1.97988391018141,-4.19191113546548,-1.36144645902812,"C21orf2","chromosome 21 open reading frame 2",TRUE
+"203996_s_at",0.585036027492332,0.0656781186419375,1.93638731202241,-4.26181685618362,0.684334541700419,"C21orf2","chromosome 21 open reading frame 2",TRUE
+"238965_at",0.606941574497969,0.0807920576994388,-1.82964704300969,-4.42876824465905,-1.55676300474303,"C21orf2","chromosome 21 open reading frame 2",TRUE
+"203995_at",0.62524538993269,0.0965298012631283,-1.73556499839281,-4.57025872839381,-1.17576873050847,"C21orf2","chromosome 21 open reading frame 2",TRUE
+"203993_x_at",0.867159108376357,0.499167078114297,0.687070787181555,-5.71233645423483,0.271359693796693,"C21orf2","chromosome 21 open reading frame 2",TRUE
+"203994_s_at",0.975398143273847,0.882174638585617,0.149932120082357,-5.92874040420022,0.146935895413177,"C21orf2","chromosome 21 open reading frame 2",TRUE
+"202217_at",0.78065889313777,0.302287844596804,-1.05613268515744,-5.4105348653265,-0.381403641480105,"C21orf33","chromosome 21 open reading frame 33",TRUE
+"210667_s_at",0.959584210327095,0.817528890740675,-0.233484468712164,-5.91316606223713,-0.0866153899387356,"C21orf33","chromosome 21 open reading frame 33",TRUE
+"1553789_a_at",0.754513748034606,0.247945523093428,1.18662020197523,-5.27619282282382,0.781940839069562,"C21orf58","chromosome 21 open reading frame 58",TRUE
+"1555198_x_at",0.784925710185113,0.310023338889122,1.03897259721857,-5.42716350139585,0.411008155047643,"C21orf58","chromosome 21 open reading frame 58",TRUE
+"1555197_a_at",0.867099100798202,0.498869987782664,0.687551548448208,-5.71202174650808,0.378046313916948,"C21orf58","chromosome 21 open reading frame 58",TRUE
+"1559439_s_at",0.895370220688938,0.573852750727346,0.570840014279567,-5.7822041517874,0.37728555970311,"C21orf58","chromosome 21 open reading frame 58",TRUE
+"238541_at",0.93174221209471,0.698640991938172,-0.392222897539766,-5.86503078399939,-0.384590526332818,"C21orf58","chromosome 21 open reading frame 58",TRUE
+"1559438_at",0.978928101156583,0.897388381217459,0.130448937441157,-5.93139856114553,0.0599061362974052,"C21orf58","chromosome 21 open reading frame 58",TRUE
+"244369_at",0.78157679232668,0.303181750131807,1.05413388380286,-5.41248435455471,0.523183353570458,"C21orf59","chromosome 21 open reading frame 59",TRUE
+"218123_at",0.942684843065067,0.74304175888156,-0.331956621567993,-5.8861535239172,-0.104243611554038,"C21orf59","chromosome 21 open reading frame 59",TRUE
+"223923_at",0.615821255316333,0.086804675111648,-1.79197936725496,-4.48607006626945,-0.91102304036906,"C21orf62","chromosome 21 open reading frame 62",TRUE
+"220543_at",0.725225714005638,0.203907314844188,-1.30912394464663,-5.13774017327329,-0.407218948396188,"C21orf62","chromosome 21 open reading frame 62",TRUE
+"1557782_s_at",0.619415519928971,0.0895509494457801,1.77551961700226,-4.51083743566034,0.570698447594734,"C21orf62-AS1","C21orf62 antisense RNA 1",TRUE
+"1559755_at",0.9116561917482,0.630730360994865,-0.487446085047309,-5.8246134409705,-0.206014273874365,"C21orf62-AS1","C21orf62 antisense RNA 1",TRUE
+"226109_at",0.643515428391208,0.114133897619954,1.64476033711937,-4.70152864066618,1.49500842045873,"C21orf91","chromosome 21 open reading frame 91",TRUE
+"220941_s_at",0.670164229230396,0.135944865723502,1.54734809784821,-4.83629923022735,1.25721321987961,"C21orf91","chromosome 21 open reading frame 91",TRUE
+"1560633_a_at",0.88113080359582,0.537403052318345,-0.626478151541729,-5.75031035915368,-0.583486496106476,"C21orf91-OT1","C21orf91 overlapping transcript 1",TRUE
+"1563346_at",0.904092974845832,0.606204515757932,0.522942964946416,-5.8073572906371,0.190783452373932,"C21orf91-OT1","C21orf91 overlapping transcript 1",TRUE
+"1558333_at",0.892746695408886,0.565766269907924,0.58302141871622,-5.77546637113306,0.207845313177469,"C22orf15","chromosome 22 open reading frame 15",TRUE
+"1558334_a_at",0.986889306520757,0.939288720588331,0.0770329593728063,-5.93679362397082,0.0238597965762466,"C22orf15","chromosome 22 open reading frame 15",TRUE
+"223706_at",0.813065886130395,0.362749338597104,0.929297733540855,-5.52759072345317,0.496135022227858,"C22orf23","chromosome 22 open reading frame 23",TRUE
+"207701_at",0.849935057946582,0.452435318985107,0.764842415668694,-5.65870657115728,0.259411280353635,"C22orf24","chromosome 22 open reading frame 24",TRUE
+"219560_at",0.812302873476553,0.357295733676323,-0.94011485284551,-5.51814046429043,-0.38556298038133,"C22orf29///GNB1L","chromosome 22 open reading frame 29///G protein subunit beta 1 like",TRUE
+"226204_at",0.98529096111871,0.927015518997198,-0.0926483999325483,-5.93550352892293,-0.036189410988472,"C22orf29///GNB1L","chromosome 22 open reading frame 29///G protein subunit beta 1 like",TRUE
+"206839_at",0.560467295493135,0.0543399567153015,2.03175980944079,-4.10717393086975,0.905606493662038,"C22orf31","chromosome 22 open reading frame 31",TRUE
+"235839_at",0.739189560382301,0.225995025447375,1.24539992159078,-5.2112184209491,0.817598074341801,"C22orf34","chromosome 22 open reading frame 34",TRUE
+"1570065_at",0.974884920935236,0.877096073682401,-0.156448754115334,-5.92776904685255,-0.133834026298775,"C22orf34","chromosome 22 open reading frame 34",TRUE
+"227086_at",0.689848451630875,0.15885865355051,-1.45804265374834,-4.9541103554717,-0.583696158167799,"C22orf39","chromosome 22 open reading frame 39",TRUE
+"1553974_at",0.994701128358967,0.975578882596124,-0.0309596859179833,-5.93921664047391,-0.0112337216907754,"C22orf39","chromosome 22 open reading frame 39",TRUE
+"1555990_at",0.767965891104819,0.270599954637336,-1.12990597158081,-5.33628060578412,-0.369298416227144,"C22orf42","chromosome 22 open reading frame 42",TRUE
+"1555991_s_at",0.977782227005336,0.89244200227247,0.136777376230913,-5.93057558491162,0.0718558709524562,"C22orf42","chromosome 22 open reading frame 42",TRUE
+"219309_at",0.763650705722297,0.263483948381727,1.14732936979384,-5.31809592720772,0.643126457881721,"C22orf46","chromosome 22 open reading frame 46",TRUE
+"212875_s_at",0.794426378358553,0.326288978864712,1.00384959660692,-5.46043191471715,0.827948808211987,"C2CD2","C2 calcium dependent domain containing 2",TRUE
+"204757_s_at",0.218155630903764,0.00264140882776939,-3.38572494521368,-1.51177198649167,-1.55001252119936,"C2CD2L","C2CD2 like",TRUE
+"204758_s_at",0.790887605610217,0.320927412552924,-1.01528889356945,-5.44971023279193,-0.922285259588921,"C2CD2L","C2CD2 like",TRUE
+"231708_at",0.8877101263145,0.552602284358646,-0.603044848803551,-5.76409210739257,-0.42986309940675,"C2CD3","C2 calcium dependent domain containing 3",TRUE
+"213199_at",0.920835753388243,0.663446818532872,-0.441055196937834,-5.84537683591288,-0.168121165042457,"C2CD3","C2 calcium dependent domain containing 3",TRUE
+"36552_at",0.980264692225439,0.907575452158393,-0.117432384523427,-5.93296893376836,-0.0405655790346309,"C2CD3","C2 calcium dependent domain containing 3",TRUE
+"1558756_at",0.985031563903634,0.926133097102978,0.0937719855624762,-5.93540155174363,0.0598239929176003,"C2CD3","C2 calcium dependent domain containing 3",TRUE
+"241031_at",0.925511384407886,0.677946198067934,-0.420811799757926,-5.8537992147907,-0.467923918102297,"C2CD4A","C2 calcium dependent domain containing 4A",TRUE
+"229727_x_at",0.899755026004388,0.591408560526782,0.54468829547995,-5.79620302494537,0.250792576474651,"C2CD4B","C2 calcium dependent domain containing 4B",TRUE
+"229306_at",0.987915939622712,0.942274962319153,0.0732366224245555,-5.93707140517394,0.0420794584307309,"C2CD4B","C2 calcium dependent domain containing 4B",TRUE
+"230819_at",0.857316604145187,0.472624897268787,0.730690269683558,-5.68292943444282,0.347351410352408,"C2CD4C","C2 calcium dependent domain containing 4C",TRUE
+"212943_at",0.605664606439963,0.079224734574093,1.83986438612805,-4.41307747041652,0.902968598468931,"C2CD5","C2 calcium dependent domain containing 5",TRUE
+"1552740_at",0.998347572104896,0.992540543777389,-0.00945523752366986,-5.93963993666036,-0.00939104100115706,"C2orf15","chromosome 2 open reading frame 15",TRUE
+"224000_at",0.729083413548563,0.211211838877386,1.28748514777317,-5.16304137626523,0.712225132259138,"C2orf16","chromosome 2 open reading frame 16",TRUE
+"242418_at",0.813021058415276,0.362095348517628,-0.930589129907883,-5.52646779295406,-0.766244635176854,"C2orf27A","chromosome 2 open reading frame 27A",TRUE
+"206611_at",0.92148618812595,0.66545881393626,0.438235115710902,-5.84657343758717,0.204097221595963,"C2orf27A","chromosome 2 open reading frame 27A",TRUE
+"223623_at",0.865345395265289,0.494984471971118,0.693854274777735,-5.70787652093375,0.500591731721431,"C2orf40","chromosome 2 open reading frame 40",TRUE
+"219128_at",0.885346001004978,0.5468823135243,0.611822974922779,-5.75898879777564,0.145592893592875,"C2orf42","chromosome 2 open reading frame 42",TRUE
+"219176_at",0.751579819725748,0.244863461041767,-1.1946304321053,-5.26749885543133,-0.334601983186326,"C2orf47","chromosome 2 open reading frame 47",TRUE
+"226951_at",0.740681080735184,0.230906689529655,-1.23188386623321,-5.22639922918212,-0.386675930566851,"C2orf49","chromosome 2 open reading frame 49",TRUE
+"243093_at",0.834454640870101,0.412657379909864,-0.834952337669618,-5.60571705272338,-0.227383488734711,"C2orf49","chromosome 2 open reading frame 49",TRUE
+"219662_at",0.978072252406502,0.893833005666657,0.134997148007704,-5.93081102655949,0.0435681155337111,"C2orf49","chromosome 2 open reading frame 49",TRUE
+"1563814_at",0.914221041533407,0.639093597228136,-0.475487758938899,-5.83015998780184,-0.37136172161261,"C2orf50","chromosome 2 open reading frame 50",TRUE
+"220149_at",0.99872918752906,0.994550922894461,-0.00690693028846629,-5.93966024509504,-0.00662816475277239,"C2orf54","chromosome 2 open reading frame 54",TRUE
+"238187_at",0.968980656821882,0.853592858328297,-0.186702488981344,-5.9227197695802,-0.0923510173510751,"C2orf57","chromosome 2 open reading frame 57",TRUE
+"1553460_at",0.89961817630669,0.590743533192431,0.545671860995791,-5.79568806220497,0.33363245997969,"C2orf61","chromosome 2 open reading frame 61",TRUE
+"232145_at",0.929126743655924,0.688382975224246,-0.406350800486039,-5.85957759076276,-0.145252665272706,"C2orf68","chromosome 2 open reading frame 68",TRUE
+"65472_at",0.957571530817866,0.809606558527596,-0.243829293700571,-5.91076766573988,-0.122325002449877,"C2orf68","chromosome 2 open reading frame 68",TRUE
+"221878_at",0.979588787486838,0.902959592350465,-0.123327597078109,-5.93227811266554,-0.0621473484761479,"C2orf68","chromosome 2 open reading frame 68",TRUE
+"238768_at",0.991124129532655,0.958497420205961,-0.0526311799826605,-5.93833438591568,-0.0202002166989246,"C2orf68","chromosome 2 open reading frame 68",TRUE
+"238974_at",0.812896635201594,0.361778782482115,-0.931214795535045,-5.52592323134825,-0.312444979322541,"C2orf69","chromosome 2 open reading frame 69",TRUE
+"227973_at",0.877857073443889,0.529002135621396,-0.639582592721838,-5.74238279656132,-0.27731629341411,"C2orf69","chromosome 2 open reading frame 69",TRUE
+"231126_at",0.423421354964585,0.0177931093633134,2.56013378320152,-3.16966107780495,1.71003697900814,"C2orf70","chromosome 2 open reading frame 70",TRUE
+"1556312_at",0.974884920935236,0.87683853690778,-0.156779398576678,-5.92771866268016,-0.0850509420799521,"C2orf71","chromosome 2 open reading frame 71",TRUE
+"213148_at",0.46205767811303,0.0232909183517057,-2.43700585775961,-3.39905301997564,-2.20181604565987,"C2orf72","chromosome 2 open reading frame 72",TRUE
+"213143_at",0.644953768720197,0.115386276909822,-1.63876293538857,-4.71000982077855,-1.2946862444933,"C2orf72","chromosome 2 open reading frame 72",TRUE
+"1556464_a_at",0.868285886165517,0.50243259521368,0.681797079458737,-5.71577482724038,0.262116146503995,"C2orf72","chromosome 2 open reading frame 72",TRUE
+"231081_at",0.981587171772385,0.912588777908165,-0.111034361095936,-5.93368044340053,-0.0784959221121286,"C2orf73","chromosome 2 open reading frame 73",TRUE
+"1568658_at",0.974821362145526,0.876593598418856,-0.157093885044083,-5.92767064222348,-0.161551718618414,"C2orf74///KIAA1841","chromosome 2 open reading frame 74///KIAA1841",TRUE
+"227840_at",0.429284714913652,0.0189373434108748,-2.53183220543683,-3.22290666680581,-0.994722593733186,"C2orf76","chromosome 2 open reading frame 76",TRUE
+"241998_at",0.978197434639598,0.894177386916734,-0.13455647263509,-5.93086883205322,-0.0971344996573968,"C2orf80","chromosome 2 open reading frame 80",TRUE
+"236070_at",0.938726197187622,0.726890636926515,-0.353722370706302,-5.87892544326363,-0.165880163100048,"C2orf81","chromosome 2 open reading frame 81",TRUE
+"230244_at",0.671016283173618,0.136964640516097,-1.54312044537602,-4.8420020897927,-1.23353162943426,"C2orf82","chromosome 2 open reading frame 82",TRUE
+"232299_at",0.971242929121865,0.863693458433807,0.173680655309143,-5.92500190700047,0.0634767718011982,"C2orf82","chromosome 2 open reading frame 82",TRUE
+"208265_at",0.968066640321622,0.849933791810216,-0.19142785086034,-5.92185098109693,-0.14828312038099,"C2orf83","chromosome 2 open reading frame 83",TRUE
+"223754_at",0.874162829001327,0.520036948808362,0.653692737819132,-5.73367053924415,0.61740853736532,"C2orf88","chromosome 2 open reading frame 88",TRUE
+"228195_at",0.94458977342259,0.750903519195966,0.321421412595888,-5.88948904248516,0.285651835849543,"C2orf88","chromosome 2 open reading frame 88",TRUE
+"217767_at",0.12932733882685,0.000780576530642168,3.88981005682267,-0.438087636572194,5.82526303632947,"C3","complement component 3",TRUE
+"209906_at",0.7994347047598,0.334547233918363,0.98648250726616,-5.47649870050187,0.617573521201021,"C3AR1","complement component 3a receptor 1",TRUE
+"236068_s_at",0.548911723996683,0.0484608484998992,-2.08842877724705,-4.01296078809095,-1.58649354924412,"C3orf14","chromosome 3 open reading frame 14",TRUE
+"219288_at",0.964681283904107,0.836405035748334,-0.208938741797199,-5.91844288677685,-0.313706234757827,"C3orf14","chromosome 3 open reading frame 14",TRUE
+"219114_at",0.95643295620889,0.802635964289555,-0.252953868163585,-5.90856638978445,-0.17294337843821,"C3orf18","chromosome 3 open reading frame 18",TRUE
+"224273_at",0.774802536186823,0.291158535134787,-1.08137863334465,-5.38562720064342,-0.526258879412173,"C3orf20","chromosome 3 open reading frame 20",TRUE
+"237894_at",0.70916118893503,0.181986719640107,-1.37791887507883,-5.05494877883918,-0.849624819956918,"C3orf22","chromosome 3 open reading frame 22",TRUE
+"1553146_at",0.821555706120251,0.384068840392019,-0.888020223031547,-5.56272523024286,-0.542064889017264,"C3orf30","chromosome 3 open reading frame 30",TRUE
+"1554176_a_at",0.545412722791443,0.0471045062098069,-2.10237369252363,-3.98951995611036,-0.798676293825069,"C3orf33","chromosome 3 open reading frame 33",TRUE
+"237368_at",0.907964244160782,0.618089781887473,-0.505658944372737,-5.81590736492511,-0.373255892090315,"C3orf35","chromosome 3 open reading frame 35",TRUE
+"221175_at",0.726636642789909,0.205918234033511,-1.30310763143644,-5.14481064112154,-0.854961422250598,"C3orf36","chromosome 3 open reading frame 36",TRUE
+"1569128_at",0.640337040581689,0.11110460503514,-1.65949935031831,-4.68058494096928,-1.22441522623416,"C3orf38","chromosome 3 open reading frame 38",TRUE
+"229174_at",0.843950128127185,0.440080572244912,-0.786195896325733,-5.64303030582974,-0.329240128236462,"C3orf38","chromosome 3 open reading frame 38",TRUE
+"1569129_s_at",0.893175412268596,0.567727939690362,0.580058254039107,-5.77711803476586,0.208298601259038,"C3orf38","chromosome 3 open reading frame 38",TRUE
+"226524_at",0.920169584950428,0.660240125781172,-0.44555734105749,-5.84345090019533,-0.172542632212918,"C3orf38","chromosome 3 open reading frame 38",TRUE
+"1553805_at",0.982243328340126,0.914271317124593,0.108888175987467,-5.93391020058708,0.0388295355793682,"C3orf49","chromosome 3 open reading frame 49",TRUE
+"1559021_at",0.947969282616012,0.7635787569807,0.304513125521308,-5.89461961978734,0.138276006292026,"C3orf52","chromosome 3 open reading frame 52",TRUE
+"219474_at",0.99886461451188,0.994908994264429,-0.00645305322205234,-5.93966319853729,-0.00365624569768741,"C3orf52","chromosome 3 open reading frame 52",TRUE
+"1562762_at",0.990810941805126,0.956323231821813,-0.0553912356149996,-5.93818918950665,-0.0370492616340012,"C3orf56","chromosome 3 open reading frame 56",TRUE
+"228079_at",0.716784133256628,0.192807393649844,-1.34319170744545,-5.09718549522546,-1.25610313951805,"C3orf58","chromosome 3 open reading frame 58",TRUE
+"235853_at",0.89967769475675,0.591213696089001,-0.544976440752076,-5.79605225500117,-0.304049868303433,"C3orf58","chromosome 3 open reading frame 58",TRUE
+"226464_at",0.969882914559333,0.8565098053196,-0.182938628127104,-5.923396295599,-0.149420520067075,"C3orf58","chromosome 3 open reading frame 58",TRUE
+"1569374_at",0.990984475090957,0.957860571960394,-0.0534395920481229,-5.93829262645374,-0.031941635011024,"C3orf62","chromosome 3 open reading frame 62",TRUE
+"239697_x_at",0.759520601932462,0.257077060070638,1.16331585850092,-5.30119573692413,0.950700739306285,"C3orf67","chromosome 3 open reading frame 67",TRUE
+"235562_at",0.927058918776758,0.681454009065165,-0.415941410670862,-5.85576753476007,-0.425421342756524,"C3orf70","chromosome 3 open reading frame 70",TRUE
+"242447_at",0.937113154905832,0.719764320504394,-0.363381034242578,-5.87557270362425,-0.29843545126669,"C3orf70","chromosome 3 open reading frame 70",TRUE
+"1555839_a_at",0.793654340638017,0.325444313226675,-1.00564302676376,-5.45875826739728,-0.89054049275647,"C3orf79","chromosome 3 open reading frame 79",TRUE
+"236738_at",0.85334340854827,0.461026745018339,-0.750200472125934,-5.66921988824504,-0.661303075961785,"C3orf80","chromosome 3 open reading frame 80",TRUE
+"231691_at",0.999369827418759,0.998121903714621,-0.00238054717870685,-5.93968072056035,-0.00139023999362475,"C3P1","complement component 3 precursor pseudogene",TRUE
+"1559036_at",0.819018525257656,0.374835053376923,0.905707143828835,-5.54785095827246,0.898556643816887,"C4B_2///C4B///C4A","complement component 4B (Chido blood group), copy 2///complement component 4B (Chido blood group)///complement component 4A (Rodgers blood group)",TRUE
+"214428_x_at",0.834303441371375,0.412459479108702,-0.835311465901133,-5.60543441361412,-0.435839714512353,"C4B_2///C4B///C4A","complement component 4B (Chido blood group), copy 2///complement component 4B (Chido blood group)///complement component 4A (Rodgers blood group)",TRUE
+"208451_s_at",0.998870448604467,0.996074040144034,-0.0049762963804765,-5.93967141935597,-0.00502574966623293,"C4B_2///C4B///C4A","complement component 4B (Chido blood group), copy 2///complement component 4B (Chido blood group)///complement component 4A (Rodgers blood group)",TRUE
+"205654_at",0.892178923218045,0.564402095953649,-0.585085156084192,-5.77431123593439,-0.44806697322048,"C4BPA","complement component 4 binding protein alpha",TRUE
+"208209_s_at",0.929126743655924,0.688311652878461,-0.406449321308663,-5.85953889602971,-0.44932275050014,"C4BPB","complement component 4 binding protein beta",TRUE
+"223990_at",0.895690630367785,0.576026522997572,0.567580361422958,-5.7839837552436,0.277496888000673,"C4orf17","chromosome 4 open reading frame 17",TRUE
+"235350_at",0.556381379241158,0.0518133071829813,-2.05540734404798,-4.06806538500822,-1.97424448582891,"C4orf19","chromosome 4 open reading frame 19",TRUE
+"219450_at",0.67368843181164,0.140269386573763,-1.52959591256788,-4.86016282974752,-1.17481881060313,"C4orf19","chromosome 4 open reading frame 19",TRUE
+"231565_at",0.996625121774816,0.983092704842769,-0.0214322315329285,-5.93945975538017,-0.0186618107463703,"C4orf22","chromosome 4 open reading frame 22",TRUE
+"236984_at",0.606900628956089,0.0805829638640095,1.83100012220988,-4.42669391617146,1.76652140423848,"C4orf26","chromosome 4 open reading frame 26",TRUE
+"224605_at",0.301989070415646,0.00579950158826788,-3.05300564470714,-2.20040274582034,-1.02064421943752,"C4orf3","chromosome 4 open reading frame 3",TRUE
+"224604_at",0.366473876333673,0.0107877999740001,-2.78356033847818,-2.73940457342561,-1.0947112621923,"C4orf3","chromosome 4 open reading frame 3",TRUE
+"224602_at",0.874834820370747,0.52150048763257,-0.651380240731968,-5.73511088774754,-0.225973262556892,"C4orf3","chromosome 4 open reading frame 3",TRUE
+"227856_at",0.92494286004622,0.675214093738249,-0.424612342532356,-5.85224761679715,-0.477627537714344,"C4orf32","chromosome 4 open reading frame 32",TRUE
+"240465_at",0.979347742195592,0.900359964540912,-0.126649707428964,-5.93187393442504,-0.112913906357902,"C4orf32","chromosome 4 open reading frame 32",TRUE
+"1552373_s_at",0.663325052838397,0.131391135294739,-1.56655219524778,-4.81023916081845,-1.18662144733494,"C4orf33","chromosome 4 open reading frame 33",TRUE
+"1552370_at",0.907255387493016,0.616362782304103,0.508160621099781,-5.81468717508863,0.23550292630627,"C4orf33","chromosome 4 open reading frame 33",TRUE
+"1552372_at",0.954238752867245,0.789596103666178,-0.270082948150585,-5.90421707860147,-0.246062343128236,"C4orf33","chromosome 4 open reading frame 33",TRUE
+"1552919_at",0.843317145101463,0.437817631365595,0.790146602058914,-5.64008537451468,0.540730033524167,"C4orf36","chromosome 4 open reading frame 36",TRUE
+"1553838_at",0.700061364939874,0.171456231448683,1.41332374979013,-5.01096806150015,0.903508555676469,"C4orf45","chromosome 4 open reading frame 45",TRUE
+"238015_at",0.55991672595029,0.0541329641220527,-2.03365979775745,-4.10404272535469,-0.84688976693162,"C4orf46","chromosome 4 open reading frame 46",TRUE
+"235088_at",0.774230543658252,0.288573558531817,-1.08734113445596,-5.37966787351228,-0.446878707397346,"C4orf46","chromosome 4 open reading frame 46",TRUE
+"201812_s_at",0.769258076576208,0.276126912865675,1.1166036343697,-5.34999863404959,0.313860641578824,"C4orf46///TOMM7","chromosome 4 open reading frame 46///translocase of outer mitochondrial membrane 7",TRUE
+"237585_at",0.856874648266698,0.471376377079861,-0.732776799550436,-5.68147962759282,-0.554953285948587,"C4orf47","chromosome 4 open reading frame 47",TRUE
+"236915_at",0.957571530817866,0.809594413073426,-0.243845173599571,-5.91076390459558,-0.200609513948234,"C4orf47","chromosome 4 open reading frame 47",TRUE
+"229860_x_at",0.823518986434235,0.390481723108259,-0.875899843906316,-5.57276121288319,-0.716747427074015,"C4orf48","chromosome 4 open reading frame 48",TRUE
+"205500_at",0.719675699464475,0.19556187085905,-1.33459739759387,-5.10749893072845,-0.724490081879233,"C5","complement component 5",TRUE
+"220088_at",0.950931310281113,0.776050389844413,0.287964440822452,-5.89937500440533,0.25411245353327,"C5AR1","complement component 5a receptor 1",TRUE
+"221149_at",0.0714488726114362,0.000213007155659151,-4.42026549917732,0.707057578703153,-3.60254399369804,"C5AR2","complement component 5a receptor 2",TRUE
+"203024_s_at",0.725127644983527,0.203175365951095,-1.31132525762017,-5.13514626943525,-0.468189503382023,"C5orf15","chromosome 5 open reading frame 15",TRUE
+"229260_at",0.979388236370534,0.90074334703846,0.126159685298436,-5.93193422644068,0.0519446411617528,"C5orf15","chromosome 5 open reading frame 15",TRUE
+"1552954_at",0.884280800556985,0.543296390370129,0.617350864654775,-5.75573856950142,0.658038944310091,"C5orf17","chromosome 5 open reading frame 17",TRUE
+"1552660_a_at",0.540483367247649,0.0447428049171536,2.12754005810773,-3.94696428632885,0.63679964661063,"C5orf22","chromosome 5 open reading frame 22",TRUE
+"203738_at",0.6708432030569,0.136674689392488,1.54431983952671,-4.84038543021765,0.532985870321939,"C5orf22","chromosome 5 open reading frame 22",TRUE
+"1565939_at",0.875938621758472,0.524259275735916,0.647030835894548,-5.73780665710936,0.290597239593164,"C5orf22","chromosome 5 open reading frame 22",TRUE
+"224875_at",0.689848451630875,0.158896370377223,-1.45790456656705,-4.95428814682587,-0.517177035119634,"C5orf24","chromosome 5 open reading frame 24",TRUE
+"224876_at",0.708894565317004,0.181148672670243,-1.38067593951494,-5.051557068723,-0.477204054949455,"C5orf24","chromosome 5 open reading frame 24",TRUE
+"229098_s_at",0.840268837320073,0.429378528502707,-0.804991858486711,-5.62889534755441,-0.366120192038592,"C5orf24","chromosome 5 open reading frame 24",TRUE
+"1553108_at",0.861656789622847,0.482322927231956,-0.714591845294356,-5.6939831443547,-0.229607518763373,"C5orf24","chromosome 5 open reading frame 24",TRUE
+"1553106_at",0.90466378569832,0.609010513126242,-0.518847999954025,-5.80940830504158,-0.187805709136178,"C5orf24","chromosome 5 open reading frame 24",TRUE
+"1553107_s_at",0.951163538450312,0.776836646666199,-0.286923947148275,-5.89966519392059,-0.0874099388960712,"C5orf24","chromosome 5 open reading frame 24",TRUE
+"221823_at",0.67606695078322,0.142609523210282,-1.52017658618018,-4.87273601849784,-0.678400195272863,"C5orf30","chromosome 5 open reading frame 30",TRUE
+"229886_at",0.769258076576208,0.275558838797977,1.11796186629745,-5.34860454904507,0.476565590861181,"C5orf34","chromosome 5 open reading frame 34",TRUE
+"219381_at",0.434309499513877,0.0197020230764262,2.51379596940773,-3.256681089272,2.53236635002665,"C5orf42","chromosome 5 open reading frame 42",TRUE
+"1562387_at",0.595997098747707,0.0726053435375837,1.88505632624319,-4.34293282738888,1.54175168247585,"C5orf42","chromosome 5 open reading frame 42",TRUE
+"220341_s_at",0.674109166218269,0.140616644549051,-1.52819004178031,-4.8620433491509,-0.711893510635149,"C5orf45","chromosome 5 open reading frame 45",TRUE
+"1554195_a_at",0.556381379241158,0.0517007598537295,2.05648448088906,-4.06627693724846,2.33829824739407,"C5orf46","chromosome 5 open reading frame 46",TRUE
+"1557057_a_at",0.843424227955276,0.438039419637486,-0.789758844242487,-5.64037503169589,-0.722006518882881,"C5orf47","chromosome 5 open reading frame 47",TRUE
+"1557056_at",0.868541339434524,0.504619738243751,-0.678275743913198,-5.71805657810437,-0.4594137175547,"C5orf47","chromosome 5 open reading frame 47",TRUE
+"239722_at",0.954577684533304,0.792019627185244,-0.266893327053473,-5.90504840726378,-0.206416317156116,"C5orf49","chromosome 5 open reading frame 49",TRUE
+"238809_at",0.54295328972902,0.0459040380024567,2.11502033662722,-3.96817512881662,0.849545111207931,"C5orf51","chromosome 5 open reading frame 51",TRUE
+"226159_at",0.861357981297227,0.481743472868712,0.715548385205757,-5.6933328978514,0.272049008894115,"C5orf51","chromosome 5 open reading frame 51",TRUE
+"230405_at",0.324623663332327,0.00742275371974287,2.94673754161454,-2.41530344644412,2.84652192394152,"C5orf56","chromosome 5 open reading frame 56",TRUE
+"1560128_x_at",0.728385463227073,0.208971605492023,1.29405908508418,-5.15539263954257,1.13877136827521,"C5orf56","chromosome 5 open reading frame 56",TRUE
+"232253_at",0.92051722798026,0.661963862404828,0.443136086266271,-5.84448905445135,0.359261415383338,"C5orf56","chromosome 5 open reading frame 56",TRUE
+"1564276_at",0.999930289476606,0.999912000856771,-0.000111541621927584,-5.9396834746893,-9.15794501064049e-05,"C5orf56","chromosome 5 open reading frame 56",TRUE
+"237955_at",0.854464019770416,0.466050585664562,0.741714126364846,-5.67522521888744,0.551492490525942,"C5orf58","chromosome 5 open reading frame 58",TRUE
+"237956_s_at",0.942600075872387,0.742649903399265,-0.332482724182722,-5.88598416575951,-0.377648786613668,"C5orf58","chromosome 5 open reading frame 58",TRUE
+"1554115_at",0.967831007578706,0.848593519383916,0.19315980536317,-5.9215271312891,0.0476374037624216,"C5orf58","chromosome 5 open reading frame 58",TRUE
+"244761_at",0.640067422642767,0.110484120190842,-1.6625600374899,-4.67621792499027,-1.14633010509821,"C5orf63","chromosome 5 open reading frame 63",TRUE
+"236642_at",0.7717895132349,0.281706444201268,1.10337017752395,-5.36350273801489,0.363173507738416,"C5orf63","chromosome 5 open reading frame 63",TRUE
+"230404_at",0.795662914172144,0.327898980925958,-1.00044008086791,-5.46360623707676,-0.79504172465895,"C5orf63","chromosome 5 open reading frame 63",TRUE
+"239623_at",0.998038817582822,0.99101258458127,0.0113920831021315,-5.93962027010929,0.0119620797546496,"C5orf63","chromosome 5 open reading frame 63",TRUE
+"1553426_at",0.944801723928361,0.751866904583868,0.320132993944648,-5.88988965684134,0.177673351882924,"C5orf64","chromosome 5 open reading frame 64",TRUE
+"220375_s_at",0.912241810302154,0.632106627362655,0.48547329039909,-5.82553774558419,0.164084761930324,"C5orf66","chromosome 5 open reading frame 66",TRUE
+"236444_x_at",0.892746695408886,0.565687522240854,0.583140479481402,-5.77539983663624,0.829971461778475,"C5orf66-AS1","C5orf66 antisense RNA 1",TRUE
+"210168_at",0.55964748859722,0.054086462363927,2.0340875289088,-4.10333755228097,0.725435682003022,"C6","complement component 6",TRUE
+"226306_at",0.860085676417428,0.479342052614823,-0.719519707213419,-5.69062438108811,-0.243617198186763,"C6orf1","chromosome 6 open reading frame 1",TRUE
+"207523_at",0.642592458809121,0.112815872159515,-1.65113219144712,-4.69249194530423,-1.14499865654911,"C6orf10","chromosome 6 open reading frame 10",TRUE
+"217925_s_at",0.369623435296638,0.0110470794703656,2.77309490695929,-2.75992479394633,0.840658116120546,"C6orf106","chromosome 6 open reading frame 106",TRUE
+"217924_at",0.468735421183467,0.0248698981560743,2.40665351159647,-3.45467086563769,0.768156677975396,"C6orf106","chromosome 6 open reading frame 106",TRUE
+"205457_at",0.505583769889284,0.0330213011847212,2.27367921257085,-3.69368219326697,0.962384849260502,"C6orf106","chromosome 6 open reading frame 106",TRUE
+"232777_s_at",0.676100991810037,0.142664419616139,-1.51995714928275,-4.87302819188784,-0.668659060896723,"C6orf118","chromosome 6 open reading frame 118",TRUE
+"230993_s_at",0.984244246588495,0.923451232234852,0.0971875630120174,-5.93508401066267,0.0765693899555044,"C6orf118","chromosome 6 open reading frame 118",TRUE
+"221787_at",0.465776708318531,0.0240683085978043,-2.42183182300152,-3.42690560275265,-0.958852081993838,"C6orf120","chromosome 6 open reading frame 120",TRUE
+"221786_at",0.724970327905974,0.202705543425541,-1.31274148776856,-5.13347551546912,-0.519292442217829,"C6orf120","chromosome 6 open reading frame 120",TRUE
+"241455_at",0.456898036702485,0.0224518144097846,2.45392083519499,-3.36789404214404,1.43113145327853,"C6orf132","chromosome 6 open reading frame 132",TRUE
+"238028_at",0.637485146909712,0.108765472416609,1.67111408269648,-4.66398048362931,1.48602316606005,"C6orf132","chromosome 6 open reading frame 132",TRUE
+"227455_at",0.778580821633075,0.298763797526008,1.06405379550186,-5.40277661027576,0.351900109097555,"C6orf136","chromosome 6 open reading frame 136",TRUE
+"227456_s_at",0.840621400595373,0.429850811483227,0.804156317403345,-5.62953035857918,0.25530413572392,"C6orf136","chromosome 6 open reading frame 136",TRUE
+"1552575_a_at",0.789378278298554,0.315712297965266,1.0265444787033,-5.43905350823374,1.43457536273386,"C6orf141","chromosome 6 open reading frame 141",TRUE
+"1554314_at",0.7994347047598,0.334637211926532,0.986294923283731,-5.47667084820418,1.40333373759129,"C6orf141","chromosome 6 open reading frame 141",TRUE
+"221100_at",0.695812999227098,0.165768483525299,1.43317510503818,-4.98590682143363,0.750249929443473,"C6orf15","chromosome 6 open reading frame 15",TRUE
+"242446_at",0.774011928861764,0.285830568405781,1.09371033966925,-5.37326980148758,0.752021779148179,"C6orf163","chromosome 6 open reading frame 163",TRUE
+"233787_at",0.924255672358332,0.673510644684054,0.426985174411398,-5.85127194010467,0.132610161192029,"C6orf163","chromosome 6 open reading frame 163",TRUE
+"231642_at",0.565956563686213,0.0568271502032572,2.00942011236334,-4.14384435264216,1.30818306601782,"C6orf201","chromosome 6 open reading frame 201",TRUE
+"223576_at",0.95877806139143,0.813075777246698,-0.239295976447296,-5.91183141937202,-0.081910166655419,"C6orf203","chromosome 6 open reading frame 203",TRUE
+"230944_at",0.804656080879986,0.343584835193857,0.967811587097357,-5.49348685979089,0.588821899757123,"C6orf223","chromosome 6 open reading frame 223",TRUE
+"239137_x_at",0.995261077491356,0.978061497884904,0.0278114730358268,-5.9393067551395,0.0102412998740711,"C6orf223","chromosome 6 open reading frame 223",TRUE
+"228458_at",0.674438494582062,0.140865389578181,-1.52718475245383,-4.86338720012524,-0.557946232274883,"C6orf226","chromosome 6 open reading frame 226",TRUE
+"221342_at",0.851733415458562,0.456397435527764,0.758069409237111,-5.66359366943161,0.496147270317118,"C6orf25","chromosome 6 open reading frame 25",TRUE
+"204968_at",0.899798994481376,0.591698767586951,0.544259253877874,-5.79642737429845,0.144947900653762,"C6orf47","chromosome 6 open reading frame 47",TRUE
+"220755_s_at",0.920119557710459,0.659806820964998,0.446166409946846,-5.84318887792351,0.173317990439882,"C6orf48","chromosome 6 open reading frame 48",TRUE
+"243943_x_at",0.771527793162888,0.280749388563651,1.10562649384728,-5.361210380665,1.2705277892299,"C6orf52","chromosome 6 open reading frame 52",TRUE
+"236504_x_at",0.828607509614823,0.399201653603366,0.859624628046818,-5.58603593370506,0.933237643167789,"C6orf52","chromosome 6 open reading frame 52",TRUE
+"239417_x_at",0.82979599608837,0.401303901646905,0.855735276947888,-5.58917394519061,0.908860788899944,"C6orf52","chromosome 6 open reading frame 52",TRUE
+"238383_at",0.157590489552653,0.00122368950140991,3.70503198420071,-0.834555059061219,2.41025444338208,"C6orf58","chromosome 6 open reading frame 58",TRUE
+"238385_at",0.923287093582264,0.670727756195591,0.430866994790397,-5.84966427015568,0.285165122702847,"C6orf58","chromosome 6 open reading frame 58",TRUE
+"222309_at",0.851319596585235,0.455335491850026,0.759881255140153,-5.66229034957858,0.317560451013879,"C6orf62","chromosome 6 open reading frame 62",TRUE
+"208809_s_at",0.953593633849874,0.786368105521523,-0.274335801438665,-5.90309337956845,-0.0823171672889114,"C6orf62","chromosome 6 open reading frame 62",TRUE
+"213875_x_at",0.998715736786698,0.994450534983367,-0.00703417828558139,-5.93965938105772,-0.00197088660958222,"C6orf62","chromosome 6 open reading frame 62",TRUE
+"225729_at",0.835952408568777,0.416124063816141,-0.828678980979108,-5.61063594059611,-0.326345461481367,"C6orf89","chromosome 6 open reading frame 89",TRUE
+"1556359_at",0.873659675709122,0.519130416907873,0.655126922727114,-5.7327747904555,0.460772235600163,"C6orf89","chromosome 6 open reading frame 89",TRUE
+"224987_at",0.954719514468953,0.793739922262473,0.264630948590362,-5.90563211754502,0.109248230592197,"C6orf89","chromosome 6 open reading frame 89",TRUE
+"224988_at",0.956938436670832,0.804670707497568,0.250288135943422,-5.90921780079015,0.0834446757741691,"C6orf89","chromosome 6 open reading frame 89",TRUE
+"224977_at",0.964398793076854,0.835936288952431,0.209546629507281,-5.91831924271415,0.0931751638128766,"C6orf89","chromosome 6 open reading frame 89",TRUE
+"230487_at",0.851650449893991,0.455717298756058,-0.759229539157434,-5.66275948900546,-0.330959441352678,"C6orf99","chromosome 6 open reading frame 99",TRUE
+"202992_at",0.635821858586292,0.106765619594315,1.68121277726286,-4.64947194850263,1.15461638479454,"C7","complement component 7",TRUE
+"235979_at",0.974884920935236,0.877397644309876,0.156061598480382,-5.92782790741792,0.0907668644816724,"C7","complement component 7",TRUE
+"223630_at",0.955816406528307,0.798453387689918,-0.258439404620789,-5.90720434144502,-0.187922805227187,"C7orf13","chromosome 7 open reading frame 13",TRUE
+"221573_at",0.593391131760132,0.0705557521275284,-1.8997796721969,-4.31982141535997,-0.518022228592175,"C7orf25///PSMA2","chromosome 7 open reading frame 25///proteasome subunit alpha 2",TRUE
+"53202_at",0.702809964629668,0.174438892229478,-1.4031236402409,-5.0237333358095,-0.569754082640247,"C7orf25///PSMA2","chromosome 7 open reading frame 25///proteasome subunit alpha 2",TRUE
+"219261_at",0.412444326023181,0.0165080116918473,-2.59402610096219,-3.10550636885135,-1.04365296539816,"C7orf26","chromosome 7 open reading frame 26",TRUE
+"222002_at",0.523670563561336,0.0389697712149255,2.19450584196432,-3.83218181031544,1.16785115412482,"C7orf26","chromosome 7 open reading frame 26",TRUE
+"47083_at",0.540483367247649,0.0448112400620664,-2.12679416244414,-3.94823020354497,-0.633940345329053,"C7orf26","chromosome 7 open reading frame 26",TRUE
+"229146_at",0.962798069144412,0.830779831844446,0.216239096701098,-5.91693435505055,0.174123842285505,"C7orf31","chromosome 7 open reading frame 31",TRUE
+"1553927_at",0.913140067375992,0.635302639924121,-0.480899509650698,-5.82766658117687,-0.182813496712404,"C7orf33","chromosome 7 open reading frame 33",TRUE
+"231435_at",0.488346123638981,0.0290112323176096,2.33478358481918,-3.58481540013364,0.687849037142308,"C7orf34","chromosome 7 open reading frame 34",TRUE
+"1555757_at",0.959203345279235,0.815195169046828,-0.236529039317678,-5.9124709308794,-0.166098744559524,"C7orf34","chromosome 7 open reading frame 34",TRUE
+"220659_s_at",0.980338871909347,0.908384598603957,-0.116399416382567,-5.9330865019226,-0.0580249602733112,"C7orf43","chromosome 7 open reading frame 43",TRUE
+"1561894_at",0.648831254679075,0.119649738121525,1.61874750174943,-4.73814194773915,1.19965639954494,"C7orf49","chromosome 7 open reading frame 49",TRUE
+"220949_s_at",0.912329443373872,0.632709095312304,0.484610303969634,-5.82594092474675,0.139471158604112,"C7orf49","chromosome 7 open reading frame 49",TRUE
+"224478_s_at",0.905462783815257,0.611743547709053,0.514868132660742,-5.81138661589716,0.226448847453154,"C7orf50","chromosome 7 open reading frame 50",TRUE
+"240147_at",0.907189812622248,0.615944789664253,0.508766605513511,-5.81439072318933,0.170707715845185,"C7orf50","chromosome 7 open reading frame 50",TRUE
+"240900_at",0.961539013416204,0.825696204622537,0.222846940816123,-5.91552446079361,0.0759432144388743,"C7orf50","chromosome 7 open reading frame 50",TRUE
+"226781_at",0.597879550155311,0.0753160276999811,-1.86613234308338,-4.37245228035275,-0.825195402536085,"C7orf55-LUC7L2///FMC1///LUC7L2","C7orf55-LUC7L2 readthrough///formation of mitochondrial complex V assembly factor 1 homolog///LUC7 like 2, pre-mRNA splicing factor",TRUE
+"220099_s_at",0.728385463227073,0.20894334976718,-1.29414234866671,-5.15529555061186,-0.333086706516234,"C7orf55-LUC7L2///LUC7L2","C7orf55-LUC7L2 readthrough///LUC7 like 2, pre-mRNA splicing factor",TRUE
+"217842_at",0.741816732763138,0.23232436838989,-1.22802333869438,-5.23070902886164,-0.39527276305205,"C7orf55-LUC7L2///LUC7L2","C7orf55-LUC7L2 readthrough///LUC7 like 2, pre-mRNA splicing factor",TRUE
+"1557636_a_at",0.6181505942496,0.0891276008174201,1.77802835738998,-4.5070732559037,2.31768465833004,"C7orf57","chromosome 7 open reading frame 57",TRUE
+"229913_at",0.864273526041174,0.491564953622358,0.699424516269349,-5.7041829913842,0.322173422767284,"C7orf61","chromosome 7 open reading frame 61",TRUE
+"231441_at",0.912332517487259,0.632842719701372,0.484418948464633,-5.82603022925784,0.299977622562201,"C7orf62","chromosome 7 open reading frame 62",TRUE
+"221172_at",0.897949253801113,0.586051129133533,0.552627427464774,-5.79202059941731,0.341036090140029,"C7orf69","chromosome 7 open reading frame 69",TRUE
+"1559627_at",0.64513208805899,0.116354429734379,-1.63416401236423,-4.71649724237875,-0.873190464237588,"C7orf71","chromosome 7 open reading frame 71",TRUE
+"224758_at",0.874406257596174,0.5203961279217,0.65312487736001,-5.73402468725353,0.300828214573253,"C7orf73","chromosome 7 open reading frame 73",TRUE
+"237271_at",0.872012740664564,0.5148344082058,-0.66194235258686,-5.72849234745157,-0.459120690265937,"C7orf77","chromosome 7 open reading frame 77",TRUE
+"206305_s_at",0.986342822130003,0.934294767563458,0.0833842730041275,-5.93629752882998,0.0516856381998467,"C8A","complement component 8 alpha subunit",TRUE
+"206979_at",0.831875452294783,0.407183555689671,0.844926230765619,-5.59782525298101,0.373899993583322,"C8B","complement component 8, beta polypeptide",TRUE
+"210324_at",0.846615322073696,0.445037377832294,-0.777585436089638,-5.64940050724681,-0.423057478479866,"C8G","complement component 8, gamma polypeptide",TRUE
+"208266_at",0.915742010892393,0.64462877942801,0.467611795847594,-5.83373941403345,0.221493947057681,"C8orf17","chromosome 8 open reading frame 17",TRUE
+"235981_at",0.618124814816155,0.0890565316236925,1.77845051433633,-4.50643945857442,1.20471138289806,"C8orf22","chromosome 8 open reading frame 22",TRUE
+"1552793_at",0.980000734884886,0.90475531952052,0.121033637716101,-5.93255094188096,0.106375583421651,"C8orf31","chromosome 8 open reading frame 31",TRUE
+"222551_s_at",0.983935461205724,0.921365198423457,0.0998451172551823,-5.9348290914886,0.0829040105093739,"C8orf33","chromosome 8 open reading frame 33",TRUE
+"218187_s_at",0.993952584307899,0.971674584193854,-0.0359114014037641,-5.93905536965366,-0.0401469668691945,"C8orf33","chromosome 8 open reading frame 33",TRUE
+"231380_at",0.875938621758472,0.524172507026162,0.647167440796584,-5.73772225291264,0.617487388238607,"C8orf34","chromosome 8 open reading frame 34",TRUE
+"1562301_at",0.904236580333156,0.606628217039235,0.522324052647489,-5.8076682880972,0.629484093651744,"C8orf34","chromosome 8 open reading frame 34",TRUE
+"1556421_at",0.95238233774064,0.782113109302201,-0.279949634660555,-5.90158339368436,-0.339937421899434,"C8orf34-AS1","C8orf34 antisense RNA 1",TRUE
+"244569_at",0.886023097762234,0.548354663851445,-0.609558831454377,-5.76031190506272,-0.264306576491224,"C8orf37","chromosome 8 open reading frame 37",TRUE
+"218541_s_at",0.506052373093096,0.0331352079684185,2.27204490152446,-3.69657075126252,4.05299497521529,"C8orf4","chromosome 8 open reading frame 4",TRUE
+"220216_at",0.974982245454858,0.87832651857824,0.154869265129133,-5.92800826778145,0.0616379858958229,"C8orf44","chromosome 8 open reading frame 44",TRUE
+"243264_s_at",0.9147179591515,0.640678998549733,0.473228806703686,-5.83119260877368,0.266224326883109,"C8orf44-SGK3///C8orf44///SGK3","C8orf44-SGK3 readthrough///chromosome 8 open reading frame 44///serum/glucocorticoid regulated kinase family member 3",TRUE
+"220038_at",0.869574215769297,0.506969953136854,0.674501432600696,-5.72048970197794,0.551358625083454,"C8orf44-SGK3///SGK3","C8orf44-SGK3 readthrough///serum/glucocorticoid regulated kinase family member 3",TRUE
+"227627_at",0.93565329131222,0.71322973120944,0.372268739068126,-5.87240881202116,0.333576083774478,"C8orf44-SGK3///SGK3","C8orf44-SGK3 readthrough///serum/glucocorticoid regulated kinase family member 3",TRUE
+"229430_at",0.778686132916778,0.299218111676805,1.06302889377636,-5.40378336695252,1.37881329908321,"C8orf46","chromosome 8 open reading frame 46",TRUE
+"228701_at",0.841813886364358,0.434066484990375,-0.796723227762904,-5.63515222325649,-0.629006527286584,"C8orf46","chromosome 8 open reading frame 46",TRUE
+"228695_at",0.989524702314661,0.948610621205785,0.0651858319865404,-5.93761406756421,0.0754672078588294,"C8orf46","chromosome 8 open reading frame 46",TRUE
+"236634_at",0.79814964343286,0.332427126822533,0.99091255523894,-5.47242454593787,1.45682471290237,"C8orf48","chromosome 8 open reading frame 48",TRUE
+"1564315_at",0.966051687342135,0.841412490440376,-0.202449867964478,-5.91974042978524,-0.107177456846623,"C8orf49","chromosome 8 open reading frame 49",TRUE
+"236296_x_at",0.947778780715578,0.761349471191799,0.307480208169498,-5.89373916830974,0.17685626314405,"C8orf58","chromosome 8 open reading frame 58",TRUE
+"227263_at",0.962177189402189,0.828095814405543,0.219726613277657,-5.91619549844268,0.114715180441216,"C8orf58","chromosome 8 open reading frame 58",TRUE
+"1555241_at",0.780237570670818,0.301677151710517,1.05750063149786,-5.40919875740382,0.492629218081104,"C8orf59","chromosome 8 open reading frame 59",TRUE
+"226165_at",0.920776262860116,0.662942068358271,-0.441763241626557,-5.8450752191083,-0.150606006945802,"C8orf59","chromosome 8 open reading frame 59",TRUE
+"1555243_x_at",0.978255630670068,0.894952484281396,0.133564746186078,-5.93099823145507,0.0629825801986286,"C8orf59","chromosome 8 open reading frame 59",TRUE
+"220712_at",0.411110107932987,0.0162449650174204,2.60126751857068,-3.09174488526117,0.714661532377437,"C8orf60","chromosome 8 open reading frame 60",TRUE
+"1569245_at",0.768852835478002,0.272762509345167,1.12467767414206,-5.34168942268543,0.79381937067948,"C8orf74","chromosome 8 open reading frame 74",TRUE
+"1569246_a_at",0.930827859648584,0.693625034711205,-0.399120818423854,-5.86239201066477,-0.279638149143656,"C8orf74","chromosome 8 open reading frame 74",TRUE
+"225702_at",0.896118635245982,0.577846327096279,-0.564856267937226,-5.78546339268139,-0.286236873957879,"C8orf76","chromosome 8 open reading frame 76",TRUE
+"226710_at",0.95245594559332,0.782398790753228,-0.279572434732912,-5.90168580276693,-0.164670977815355,"C8orf82","chromosome 8 open reading frame 82",TRUE
+"228107_at",0.0952827619788257,0.00040617691579076,4.15694796450404,0.138163242549591,3.11881877905132,"C8orf88","chromosome 8 open reading frame 88",TRUE
+"1557961_s_at",0.352587061702743,0.00936362896373814,2.84569174518959,-2.61689822661424,3.44569749328933,"C8orf88","chromosome 8 open reading frame 88",TRUE
+"206727_at",0.725991386434717,0.205045725396514,1.30571239035396,-5.14175287143518,0.87529557517516,"C9","complement component 9",TRUE
+"59437_at",0.345823377376834,0.00883303883169119,-2.87116774806277,-2.56633933809959,-1.33320985559625,"C9orf116","chromosome 9 open reading frame 116",TRUE
+"221946_at",0.62601605985821,0.0969795341014914,-1.73307605474047,-4.57392722721571,-1.76224474645183,"C9orf116","chromosome 9 open reading frame 116",TRUE
+"230985_at",0.429960090499345,0.019048213487092,2.52917546836112,-3.22788944115496,1.20807538679478,"C9orf131","chromosome 9 open reading frame 131",TRUE
+"236519_at",0.990810941805126,0.954054098340288,0.0582722913791566,-5.93802971531836,0.0558971657365466,"C9orf135","chromosome 9 open reading frame 135",TRUE
+"243610_at",0.994050962712312,0.971956150649561,-0.0355542690521105,-5.93906780005625,-0.0363001142642085,"C9orf135","chromosome 9 open reading frame 135",TRUE
+"236071_at",0.51531387545335,0.0355284421127243,-2.23884241724521,-3.75498667658564,-1.28266216282862,"C9orf135-AS1","C9orf135 antisense RNA 1 (head to head)",TRUE
+"226070_at",0.522403182336918,0.0382474611594821,-2.20350810396453,-3.81658391162916,-1.06360237431543,"C9orf142","chromosome 9 open reading frame 142",TRUE
+"229964_at",0.693043612045516,0.162350298730297,-1.44537000670393,-4.9703697150771,-1.84856137816948,"C9orf152","chromosome 9 open reading frame 152",TRUE
+"222166_at",0.740610299769501,0.230013511642996,1.23432535861707,-5.22366758347764,0.77989473462804,"C9orf16","chromosome 9 open reading frame 16",TRUE
+"222165_x_at",0.93527815307551,0.712208735195662,0.3736601419265,-5.87190666332041,0.155168842564173,"C9orf16","chromosome 9 open reading frame 16",TRUE
+"204480_s_at",0.94632739401154,0.757169175856212,-0.313051626661732,-5.89206305269471,-0.12586167150708,"C9orf16","chromosome 9 open reading frame 16",TRUE
+"41047_at",0.948429371744093,0.765733059840798,-0.301648490683775,-5.89546164253832,-0.12233534861018,"C9orf16","chromosome 9 open reading frame 16",TRUE
+"1553642_at",0.77938352158119,0.300600755046289,1.05991655516569,-5.40683527451204,0.40219466302753,"C9orf163","chromosome 9 open reading frame 163",TRUE
+"236744_at",0.609499207369658,0.0817236157151708,-1.82365544881835,-4.43794038647712,-1.03907832665007,"C9orf172","chromosome 9 open reading frame 172",TRUE
+"238093_at",0.757361197594703,0.253334332706923,-1.1727918119937,-5.291081431836,-0.461385374839238,"C9orf173-AS1","C9orf173 antisense RNA 1",TRUE
+"1566906_at",0.981587171772385,0.912657919087315,0.110946156696461,-5.93368997427095,0.0613934368614579,"C9orf173-AS1","C9orf173 antisense RNA 1",TRUE
+"229012_at",0.976422537443518,0.887740733224092,-0.142797522045931,-5.92975658965256,-0.0938281799503224,"C9orf24","chromosome 9 open reading frame 24",TRUE
+"1559723_s_at",0.826617572584789,0.394883418033507,0.867655313974761,-5.57951471083462,0.61428660907918,"C9orf3","chromosome 9 open reading frame 3",TRUE
+"212848_s_at",0.917601067333473,0.650581343857283,0.459175296370207,-5.83750864347866,0.311212104929137,"C9orf3","chromosome 9 open reading frame 3",TRUE
+"232270_at",0.925091998149497,0.675808603641568,0.423784799377548,-5.85258663475492,0.243234694476691,"C9orf3","chromosome 9 open reading frame 3",TRUE
+"1559722_at",0.951102506952277,0.776658469864125,0.287159709195986,-5.89959953214214,0.269388336634967,"C9orf3","chromosome 9 open reading frame 3",TRUE
+"208077_at",0.715493644680006,0.191230153263995,1.34815637641357,-5.0912024491329,1.05993198830063,"C9orf38","chromosome 9 open reading frame 38",TRUE
+"222781_s_at",0.873301865850313,0.518286205477003,-0.656463756574133,-5.73193814836922,-0.318638610410531,"C9orf40","chromosome 9 open reading frame 40",TRUE
+"218904_s_at",0.95982935547835,0.818352176222748,-0.232410951118713,-5.91340902978054,-0.129829175584547,"C9orf40","chromosome 9 open reading frame 40",TRUE
+"1557885_at",0.987967825391489,0.942444548034294,0.0730210658322208,-5.93708675676307,0.044278236165284,"C9orf41-AS1","C9orf41 antisense RNA 1",TRUE
+"1554280_a_at",0.778974960380281,0.300097942877006,1.0610472056807,-5.40572750506897,0.394326366828996,"C9orf43","chromosome 9 open reading frame 43",TRUE
+"1564274_at",0.745510155593313,0.237121928520517,-1.21508994351579,-5.24506234743836,-0.950635409856837,"C9orf47","chromosome 9 open reading frame 47",TRUE
+"231286_at",0.833565279747698,0.41105783397453,-0.837858146417234,-5.60342688075495,-0.51430115618765,"C9orf47","chromosome 9 open reading frame 47",TRUE
+"230335_at",0.95560177469038,0.796588241153424,-0.26088818790245,-5.90658694005567,-0.146626170121602,"C9orf50","chromosome 9 open reading frame 50",TRUE
+"240316_at",0.941408730862225,0.738129874409377,0.338558252697066,-5.88400916478859,0.194782537691215,"C9orf57","chromosome 9 open reading frame 57",TRUE
+"1553919_at",0.912252515563073,0.63254714207199,0.484842252133063,-5.82583262964957,0.360014360558658,"C9orf62","chromosome 9 open reading frame 62",TRUE
+"235940_at",0.943464796017993,0.747065836912271,0.326559415731449,-5.88787561582328,0.352929486788462,"C9orf64","chromosome 9 open reading frame 64",TRUE
+"223697_x_at",0.992376456171815,0.964326098287454,-0.045233884192017,-5.93868694793205,-0.0148242683959214,"C9orf64","chromosome 9 open reading frame 64",TRUE
+"1552757_s_at",0.705559553212919,0.177580527908176,-1.39252925627427,-5.03691124203892,-1.15774142075055,"C9orf66","chromosome 9 open reading frame 66",TRUE
+"1552755_at",0.737037362362438,0.222409937904501,-1.25540756687467,-5.19988642093133,-1.48246508211237,"C9orf66","chromosome 9 open reading frame 66",TRUE
+"224962_at",0.715352956634026,0.191030433643848,-1.34878732604429,-5.09044075201034,-0.454779924343947,"C9orf69","chromosome 9 open reading frame 69",TRUE
+"1553134_s_at",0.68041487556515,0.148084203386353,1.49862551705059,-4.90126961256292,1.5600110534726,"C9orf72","chromosome 9 open reading frame 72",TRUE
+"1553133_at",0.853271570300588,0.459775651259728,-0.75232240714385,-5.66770819605885,-0.536278404893056,"C9orf72","chromosome 9 open reading frame 72",TRUE
+"225919_s_at",0.996975290336506,0.984575780552714,-0.0195519745953768,-5.93949728811186,-0.0118325032682067,"C9orf72","chromosome 9 open reading frame 72",TRUE
+"218116_at",0.740610299769501,0.230670015370682,-1.232530112917,-5.22567663473524,-0.377444878597199,"C9orf78","chromosome 9 open reading frame 78",TRUE
+"1553920_at",0.846615322073696,0.445084975190991,0.777503039407194,-5.64946114656139,0.689169255459284,"C9orf84","chromosome 9 open reading frame 84",TRUE
+"233504_at",0.998459269541497,0.993601653342174,0.00811019417930066,-5.93965144410089,0.00667611334411955,"C9orf84","chromosome 9 open reading frame 84",TRUE
+"235866_at",0.623852759019384,0.095493914492884,-1.74133580982007,-4.5617380010853,-0.660661553278833,"C9orf85","chromosome 9 open reading frame 85",TRUE
+"238912_x_at",0.865345395265289,0.495174943372012,-0.693544653534722,-5.70808099848249,-0.243500121524756,"C9orf85","chromosome 9 open reading frame 85",TRUE
+"238579_at",0.992011565988589,0.963017794018772,0.0468940400247917,-5.93861246084885,0.0232432270716414,"C9orf85","chromosome 9 open reading frame 85",TRUE
+"205950_s_at",0.746259710622309,0.23790424304472,-1.21299976429342,-5.24736965521402,-0.804657521414257,"CA1","carbonic anhydrase 1",TRUE
+"205949_at",0.7580556532611,0.254670407433808,1.16939722888266,-5.29471295051245,0.42443991695569,"CA1","carbonic anhydrase 1",TRUE
+"223550_s_at",0.851733415458562,0.45664332429803,-0.757650245058218,-5.6638947687209,-0.355618295073056,"CA10","carbonic anhydrase 10",TRUE
+"220889_s_at",0.896118635245982,0.577785965015883,0.564946555563406,-5.78541446201995,0.515405080047535,"CA10","carbonic anhydrase 10",TRUE
+"209726_at",0.547343369043481,0.0478979414276492,-2.09417309817381,-4.00331696555662,-1.04312870398369,"CA11","carbonic anhydrase 11",TRUE
+"204508_s_at",0.274882222151803,0.00440414863475043,-3.17037375097458,-1.95998479995862,-6.32663085743069,"CA12","carbonic anhydrase 12",TRUE
+"203963_at",0.30050033261608,0.0056563939205399,-3.06370810250405,-2.17860758980472,-5.1424630867609,"CA12","carbonic anhydrase 12",TRUE
+"214164_x_at",0.308621629697291,0.00631162302170508,-3.0166831046922,-2.27416985430693,-4.04744388921925,"CA12","carbonic anhydrase 12",TRUE
+"210735_s_at",0.348854934125219,0.00916675663898093,-2.85498001259374,-2.59848656130326,-3.9169557896002,"CA12","carbonic anhydrase 12",TRUE
+"215867_x_at",0.348854934125219,0.00919432940236747,-2.8536677718908,-2.6010892580525,-3.49316579156331,"CA12","carbonic anhydrase 12",TRUE
+"241230_at",0.592007267652348,0.0691045275024208,-1.91043294207137,-4.30302062644561,-1.50485472193485,"CA12","carbonic anhydrase 12",TRUE
+"204509_at",0.975475861996229,0.88317243112044,0.148652578200716,-5.92892628775559,0.094081705851031,"CA12","carbonic anhydrase 12",TRUE
+"219464_at",0.726432421917557,0.205314479777172,1.30490914382721,-5.14269636733152,0.799860119375103,"CA14","carbonic anhydrase 14",TRUE
+"209301_at",0.837609393049242,0.421921906651051,0.818260335822599,-5.61872837867644,1.74134062992232,"CA2","carbonic anhydrase 2",TRUE
+"204865_at",0.575270671804438,0.0608917947598182,1.97471618025706,-4.20027171012993,1.83782682628874,"CA3","carbonic anhydrase 3",TRUE
+"206208_at",0.738840835789512,0.225523817256354,-1.24670833106485,-5.20974129110373,-0.72740668741671,"CA4","carbonic anhydrase 4",TRUE
+"206209_s_at",0.936599157163462,0.716895330425525,0.367279437661355,-5.87419421985406,0.217826267018737,"CA4","carbonic anhydrase 4",TRUE
+"207421_at",0.91671872326659,0.647764334341992,0.463163556577757,-5.83573515960363,0.301348226329837,"CA5A","carbonic anhydrase 5A",TRUE
+"214082_at",0.348854934125219,0.00909350349062157,-2.85848462910921,-2.59153308641797,-2.02553298301328,"CA5B","carbonic anhydrase 5B",TRUE
+"207129_at",0.947062793209778,0.759702413314735,-0.309674180185464,-5.89308268913702,-0.227706854568806,"CA5B","carbonic anhydrase 5B",TRUE
+"239106_at",0.853793505235478,0.462649111652702,-0.747453950281815,-5.6711705389373,-0.261815806934157,"CA5BP1","carbonic anhydrase 5B pseudogene 1",TRUE
+"213363_at",0.96567534940972,0.839462612552699,-0.204975530385858,-5.91924023321619,-0.0797809976203148,"CA5BP1","carbonic anhydrase 5B pseudogene 1",TRUE
+"238435_at",0.965255754814725,0.838200196176904,0.206611455643023,-5.91891294933754,0.064060627886791,"CA5BP1///CA5B","carbonic anhydrase 5B pseudogene 1///carbonic anhydrase 5B",TRUE
+"1555572_at",0.748440891167983,0.241347565690683,-1.20386107135498,-5.25741721758953,-1.1106356956243,"CA6","carbonic anhydrase 6",TRUE
+"206873_at",0.909441642299191,0.624028200190982,0.497081509624044,-5.82004637832582,0.243970774593819,"CA6","carbonic anhydrase 6",TRUE
+"207504_at",0.767727587789514,0.269797532597302,1.13185372941072,-5.3342599318074,0.672782785179089,"CA7","carbonic anhydrase 7",TRUE
+"220234_at",0.705559553212919,0.177323012166266,-1.39339202185811,-5.03584117192969,-1.87355811552187,"CA8","carbonic anhydrase 8",TRUE
+"238537_at",0.725168361556674,0.203499997833986,-1.31034817749248,-5.13629806078832,-1.77365062806137,"CA8","carbonic anhydrase 8",TRUE
+"1555445_at",0.878260796317638,0.530673708201553,0.636966209959587,-5.74397819425307,0.478744378635915,"CA8","carbonic anhydrase 8",TRUE
+"205199_at",0.725991386434717,0.205078873225664,1.30561327472931,-5.14186931954858,0.574550622439983,"CA9","carbonic anhydrase 9",TRUE
+"231995_at",0.834881450121645,0.413603381927874,-0.833237144096885,-5.6070653676586,-0.459614801208152,"CAAP1","caspase activity and apoptosis inhibitor 1",TRUE
+"219276_x_at",0.839519981963042,0.428228125779008,-0.807029489770958,-5.62734415163333,-0.33277433728661,"CAAP1","caspase activity and apoptosis inhibitor 1",TRUE
+"229462_at",0.955203530479627,0.795160263350996,0.262764106288979,-5.90611005986772,0.095629983664566,"CAAP1","caspase activity and apoptosis inhibitor 1",TRUE
+"224311_s_at",0.512732523931824,0.0343040799733445,2.25556446174514,-3.72563022008291,0.926834503896282,"CAB39","calcium binding protein 39",TRUE
+"217873_at",0.615821255316333,0.0867072312606945,1.79257159718926,-4.48517582137774,0.699052298939554,"CAB39","calcium binding protein 39",TRUE
+"225914_s_at",0.560923390313819,0.0545585841735508,-2.02976001649625,-4.11046752596521,-0.936185240352399,"CAB39L","calcium binding protein 39 like",TRUE
+"221003_s_at",0.592488489935347,0.0695671685455424,-1.90701561403682,-4.30841706542517,-1.7996767827756,"CAB39L","calcium binding protein 39 like",TRUE
+"225915_at",0.645740804644555,0.116920104781269,-1.63149179054676,-4.72026034653791,-1.05934783177854,"CAB39L","calcium binding protein 39 like",TRUE
+"202624_s_at",0.735165878294211,0.220191596831251,-1.26166194173487,-5.19276488927058,-0.474134501357707,"CABIN1","calcineurin binding protein 1",TRUE
+"37652_at",0.784448016670989,0.30751103996885,-1.04451219176693,-5.42182224161634,-0.389302175345799,"CABIN1","calcineurin binding protein 1",TRUE
+"225532_at",0.597654932724127,0.0738621437720527,-1.8762068936578,-4.35676314558963,-1.1341476501935,"CABLES1","Cdk5 and Abl enzyme substrate 1",TRUE
+"1558621_at",0.812896635201594,0.36196344956413,-0.930849772340765,-5.52624097807076,-0.660854367753088,"CABLES1","Cdk5 and Abl enzyme substrate 1",TRUE
+"225531_at",0.839519981963042,0.427557910700102,-0.808218166532448,-5.62643754238431,-0.329346649456646,"CABLES1","Cdk5 and Abl enzyme substrate 1",TRUE
+"226004_at",0.937623890519979,0.723794479419641,-0.357914485542475,-5.8774812222702,-0.146293677511416,"CABLES2","Cdk5 and Abl enzyme substrate 2",TRUE
+"208320_at",0.784925710185113,0.310036667161495,-1.03894329321118,-5.42719168824115,-0.48132263138195,"CABP1","calcium binding protein 1",TRUE
+"210181_s_at",0.822600785740588,0.38768682298973,-0.881166147722922,-5.56841629440324,-0.708141512336245,"CABP1","calcium binding protein 1",TRUE
+"208321_s_at",0.991880277547267,0.962695144923389,0.047303482012448,-5.9385936776015,0.0266426177954582,"CABP1","calcium binding protein 1",TRUE
+"207745_at",0.78157679232668,0.303177945978793,-1.05414238113115,-5.41247607387887,-0.770830662847242,"CABP2","calcium binding protein 2",TRUE
+"1554202_x_at",0.675334226639578,0.141495214752325,1.52464585372852,-4.86677801789629,0.39939110194674,"CABP4","calcium binding protein 4",TRUE
+"1552890_a_at",0.863832858913113,0.489655381132788,0.702544796449975,-5.70210167938293,0.400548215636543,"CABP4","calcium binding protein 4",TRUE
+"1554201_at",0.932269331146744,0.701468196032836,-0.388343480075656,-5.86649492641428,-0.239372811240903,"CABP4","calcium binding protein 4",TRUE
+"221160_s_at",0.959969342594555,0.818873209034513,0.231731698210645,-5.91356218865057,0.132117674550943,"CABP5","calcium binding protein 5",TRUE
+"243173_at",0.907964244160782,0.61811605577419,0.50562091013428,-5.81592587074303,0.417491755666306,"CABP7","calcium binding protein 7",TRUE
+"234796_at",0.998000510878671,0.990502393726372,0.0120388121041614,-5.93961288947648,0.00569841611549071,"CABP7","calcium binding protein 7",TRUE
+"231612_at",0.997263441064271,0.985970744739035,-0.0177834923072056,-5.93952944694233,-0.0134818864023925,"CABS1","calcium binding protein, spermatid associated 1",TRUE
+"224279_s_at",0.617775129514679,0.0887631181384491,1.78019649087446,-4.50381700202394,1.14295549084254,"CABYR","calcium binding tyrosine phosphorylation regulated",TRUE
+"219928_s_at",0.647518308302168,0.118476198814818,1.62419642549333,-4.73050975610763,0.698814405870534,"CABYR","calcium binding tyrosine phosphorylation regulated",TRUE
+"61874_at",0.656693876264681,0.124818479068983,-1.59526736285871,-4.7708027032892,-0.621435059238017,"CACFD1","calcium channel flower domain containing 1",TRUE
+"219223_at",0.808647629330242,0.351841215439179,-0.951045515003966,-5.50848908875675,-0.485895397668804,"CACFD1","calcium channel flower domain containing 1",TRUE
+"225627_s_at",0.591272702915983,0.0685333450840462,1.91467982509979,-4.2963048502278,1.95269530887165,"CACHD1","cache domain containing 1",TRUE
+"234888_at",0.839888048402106,0.42871926748498,-0.806159147640194,-5.62800717108529,-0.337320550072706,"CACHD1","cache domain containing 1",TRUE
+"207162_s_at",0.621733119678766,0.0920626727587773,1.76084161077491,-4.53278258121839,0.557777852670061,"CACNA1B","calcium voltage-gated channel subunit alpha1 B",TRUE
+"235781_at",0.939682421466574,0.729493492120605,0.350203168680624,-5.8801248592157,0.272366155278468,"CACNA1B","calcium voltage-gated channel subunit alpha1 B",TRUE
+"208020_s_at",0.612420348961838,0.0841513173510393,1.80831454425837,-4.46132600217474,1.1622559265349,"CACNA1C","calcium voltage-gated channel subunit alpha1 C",TRUE
+"238636_at",0.831504528407028,0.40621729139706,0.846695712075488,-5.59641602233823,0.381651139865546,"CACNA1C","calcium voltage-gated channel subunit alpha1 C",TRUE
+"211592_s_at",0.886567073863495,0.549549971656291,-0.607723076918788,-5.76138119866592,-0.520259308375734,"CACNA1C","calcium voltage-gated channel subunit alpha1 C",TRUE
+"242973_at",0.954577684533304,0.792677269858745,0.266028286749116,-5.90527217677856,0.153903108346609,"CACNA1C","calcium voltage-gated channel subunit alpha1 C",TRUE
+"210108_at",0.399312926596283,0.0141711684251265,-2.66255429511859,-2.97453301300876,-3.25059183910591,"CACNA1D","calcium voltage-gated channel subunit alpha1 D",TRUE
+"207998_s_at",0.439734782930756,0.0203005655326149,-2.50012831091884,-3.282191590709,-1.95232364085892,"CACNA1D","calcium voltage-gated channel subunit alpha1 D",TRUE
+"243334_at",0.55937703282623,0.0531156448727179,-2.04309301928148,-4.08846808228156,-1.61414558065673,"CACNA1D","calcium voltage-gated channel subunit alpha1 D",TRUE
+"1555993_at",0.770008266045778,0.278587928725115,-1.11074288915584,-5.3559968602543,-0.46516067251294,"CACNA1D","calcium voltage-gated channel subunit alpha1 D",TRUE
+"242410_s_at",0.751464513744428,0.244665253656605,-1.19514815003831,-5.26693519410973,-1.11851595895866,"CACNA1E","calcium voltage-gated channel subunit alpha1 E",TRUE
+"240650_at",0.774447611376107,0.290836186902282,1.08212007763233,-5.38488774281697,0.966792356550527,"CACNA1E","calcium voltage-gated channel subunit alpha1 E",TRUE
+"238747_at",0.834650577370838,0.413180658932219,-0.834003274687285,-5.60646343215095,-0.524491007605912,"CACNA1E","calcium voltage-gated channel subunit alpha1 E",TRUE
+"208432_s_at",0.853297110808539,0.460069047293929,0.751824479106281,-5.66806328904243,0.339752889155059,"CACNA1E","calcium voltage-gated channel subunit alpha1 E",TRUE
+"244256_at",0.853460708803218,0.461881262497657,0.748753132701578,-5.67024867069144,0.567150667000717,"CACNA1E","calcium voltage-gated channel subunit alpha1 E",TRUE
+"236013_at",0.990810941805126,0.954823160453475,-0.057295779197075,-5.93808467331461,-0.0218830213590051,"CACNA1E","calcium voltage-gated channel subunit alpha1 E",TRUE
+"208377_s_at",0.907111393934291,0.615629613307076,0.509223659777465,-5.81416690101962,0.216552849754998,"CACNA1F","calcium voltage-gated channel subunit alpha1 F",TRUE
+"211315_s_at",0.462669793287247,0.0234165610908404,2.43452190756693,-3.40361888252883,1.37059660462461,"CACNA1G","calcium voltage-gated channel subunit alpha1 G",TRUE
+"210380_s_at",0.62110896023334,0.0912931772464276,1.76530144553552,-4.52612880734573,0.730693190900475,"CACNA1G","calcium voltage-gated channel subunit alpha1 G",TRUE
+"211314_at",0.785175995766517,0.31065843500224,1.03757723950066,-5.42850486896734,0.307469025788529,"CACNA1G","calcium voltage-gated channel subunit alpha1 G",TRUE
+"207869_s_at",0.810589895425672,0.354670520832448,-0.94536152256612,-5.51352061408162,-0.798105420890638,"CACNA1G","calcium voltage-gated channel subunit alpha1 G",TRUE
+"211802_x_at",0.942502815705589,0.741863887868959,0.33353831226063,-5.88564356016555,0.172009313212767,"CACNA1G","calcium voltage-gated channel subunit alpha1 G",TRUE
+"1559061_at",0.597654932724127,0.075056535085095,1.86791795745809,-4.36967588640004,0.835196303571108,"CACNA1G-AS1","CACNA1G antisense RNA 1",TRUE
+"205845_at",0.760244814241272,0.258512789630667,-1.15970800471902,-5.30502773173369,-1.37735300616651,"CACNA1H","calcium voltage-gated channel subunit alpha1 H",TRUE
+"222960_at",0.854400503339099,0.465563525774197,0.742534485119845,-5.67464752241347,0.369243500226725,"CACNA1H","calcium voltage-gated channel subunit alpha1 H",TRUE
+"211830_s_at",0.897949253801113,0.585809393332217,0.552986497996929,-5.79183004776073,0.211004904192208,"CACNA1I","calcium voltage-gated channel subunit alpha1 I",TRUE
+"221631_at",0.937655803006818,0.724215237003546,0.357344408755921,-5.87767860623227,0.165383421266482,"CACNA1I","calcium voltage-gated channel subunit alpha1 I",TRUE
+"208299_at",0.940044918888428,0.731094502499007,-0.348040755362561,-5.88085597521187,-0.11866910487001,"CACNA1I","calcium voltage-gated channel subunit alpha1 I",TRUE
+"217515_s_at",0.724970327905974,0.202975329845058,1.31192793329517,-5.13443546767755,0.848740506616287,"CACNA1S","calcium voltage-gated channel subunit alpha1 S",TRUE
+"227623_at",0.722442821599878,0.199110066751114,1.3236652217442,-5.12053742343123,1.81894295657174,"CACNA2D1","calcium voltage-gated channel auxiliary subunit alpha2delta 1",TRUE
+"207050_at",0.990918916504081,0.957244778028794,-0.0542213125716047,-5.93825164058561,-0.040161780711796,"CACNA2D1","calcium voltage-gated channel auxiliary subunit alpha2delta 1",TRUE
+"204811_s_at",0.984244246588495,0.923371323865568,-0.0972893509188314,-5.93507437344632,-0.0377636167304338,"CACNA2D2","calcium voltage-gated channel auxiliary subunit alpha2delta 2",TRUE
+"219714_s_at",0.925245959757418,0.676195668071217,-0.42324617692302,-5.85280694192664,-0.335998778270524,"CACNA2D3","calcium voltage-gated channel auxiliary subunit alpha2delta 3",TRUE
+"1552690_a_at",0.84571977676742,0.443366831586729,0.780480761537122,-5.64726586348123,0.246412993857754,"CACNA2D4","calcium voltage-gated channel auxiliary subunit alpha2delta 4",TRUE
+"228083_at",0.867259912702635,0.499452147613969,0.686609631146948,-5.7126381306951,0.514625461744079,"CACNA2D4","calcium voltage-gated channel auxiliary subunit alpha2delta 4",TRUE
+"210967_x_at",0.769258076576208,0.275343598373017,1.11847702694481,-5.34807539718888,0.591803487387097,"CACNB1","calcium voltage-gated channel auxiliary subunit beta 1",TRUE
+"210185_at",0.956734254923335,0.804072158931347,0.251072105580009,-5.9090269382405,0.174374082490702,"CACNB1","calcium voltage-gated channel auxiliary subunit beta 1",TRUE
+"206996_x_at",0.973615804712521,0.873110091016987,-0.161568273656397,-5.92697702761928,-0.077983255326945,"CACNB1","calcium voltage-gated channel auxiliary subunit beta 1",TRUE
+"1559419_at",0.645555818344348,0.116560165316788,1.63319086819812,-4.71786820188557,1.15551836510968,"CACNB2","calcium voltage-gated channel auxiliary subunit beta 2",TRUE
+"215365_at",0.675158868445887,0.141366597640028,1.52516356909161,-4.8660869492415,0.722470852754231,"CACNB2","calcium voltage-gated channel auxiliary subunit beta 2",TRUE
+"207776_s_at",0.760439386481756,0.259428163065848,1.15741550009188,-5.30745723400154,0.579895140474729,"CACNB2","calcium voltage-gated channel auxiliary subunit beta 2",TRUE
+"1559420_x_at",0.826134344333512,0.39390636445848,0.869480210582391,-5.57802496301229,0.79841737336961,"CACNB2","calcium voltage-gated channel auxiliary subunit beta 2",TRUE
+"213714_at",0.910345048336855,0.627326390236629,-0.492333930669372,-5.8223075809607,-0.338778146093176,"CACNB2","calcium voltage-gated channel auxiliary subunit beta 2",TRUE
+"1555098_a_at",0.948814396904806,0.767079425998198,0.299859500095052,-5.8959834915975,0.251142695507962,"CACNB2","calcium voltage-gated channel auxiliary subunit beta 2",TRUE
+"209530_at",0.83030603167465,0.402635114563288,-0.853279169800979,-5.59114875601282,-0.760639495812836,"CACNB3","calcium voltage-gated channel auxiliary subunit beta 3",TRUE
+"34726_at",0.848475456105025,0.448829351770046,-0.771037806465843,-5.65420028930439,-0.516514058366139,"CACNB3","calcium voltage-gated channel auxiliary subunit beta 3",TRUE
+"243244_at",0.713330901550199,0.187856515181668,-1.35888467586721,-5.07821045332462,-1.06852518241593,"CACNB4","calcium voltage-gated channel auxiliary subunit beta 4",TRUE
+"207693_at",0.985498770484702,0.929264597298174,0.0897852031024069,-5.93575784107548,0.0428197689532164,"CACNB4","calcium voltage-gated channel auxiliary subunit beta 4",TRUE
+"206612_at",0.949259609170322,0.77100959852071,-0.294642949542536,-5.89748758938838,-0.194647968381434,"CACNG1","calcium voltage-gated channel auxiliary subunit gamma 1",TRUE
+"244099_at",0.547195868806649,0.0476539278181603,2.09668204188665,-3.99909949349065,0.966005470460884,"CACNG2","calcium voltage-gated channel auxiliary subunit gamma 2",TRUE
+"214495_at",0.906878681039516,0.615247719764099,-0.509777611532789,-5.81389536482975,-0.335790079670055,"CACNG2","calcium voltage-gated channel auxiliary subunit gamma 2",TRUE
+"206384_at",0.871165715950006,0.511832762569036,0.666723083431997,-5.72546304846747,0.278039795609268,"CACNG3","calcium voltage-gated channel auxiliary subunit gamma 3",TRUE
+"62987_r_at",0.355995164483342,0.0095900897870712,-2.83523484317162,-2.63759649500657,-1.76743797439209,"CACNG4","calcium voltage-gated channel auxiliary subunit gamma 4",TRUE
+"221585_at",0.603329945678563,0.0774866553005006,-1.85140234452788,-4.39528365815585,-2.77307070007214,"CACNG4","calcium voltage-gated channel auxiliary subunit gamma 4",TRUE
+"231737_at",0.67083802643975,0.136340205251145,-1.54570605521916,-4.83851571668244,-1.40358402669563,"CACNG4","calcium voltage-gated channel auxiliary subunit gamma 4",TRUE
+"1552602_at",0.591331966259927,0.0687172306263822,1.91330920985398,-4.29847339382558,0.596753680699715,"CACNG5","calcium voltage-gated channel auxiliary subunit gamma 5",TRUE
+"221401_at",0.901430889731657,0.598120229881275,0.534791976102897,-5.80133414857486,0.249839609978964,"CACNG5","calcium voltage-gated channel auxiliary subunit gamma 5",TRUE
+"1552863_a_at",0.670409852865276,0.136166463942732,1.54642720527302,-4.8375425122977,0.393642075846252,"CACNG6","calcium voltage-gated channel auxiliary subunit gamma 6",TRUE
+"224291_at",0.918041148686074,0.651630595912117,0.457691722379954,-5.83816451848926,0.310680437369552,"CACNG6","calcium voltage-gated channel auxiliary subunit gamma 6",TRUE
+"224137_at",0.594972224548427,0.0716360656355462,1.8919732080618,-4.3320909925203,0.893704483952376,"CACNG7","calcium voltage-gated channel auxiliary subunit gamma 7",TRUE
+"231355_at",0.881941608190668,0.538972381426151,0.624042449104618,-5.75176643441651,0.251849441775463,"CACNG8","calcium voltage-gated channel auxiliary subunit gamma 8",TRUE
+"234750_at",0.892895911526563,0.566503214541027,0.581907623744652,-5.77608815422055,0.315416116073291,"CACNG8","calcium voltage-gated channel auxiliary subunit gamma 8",TRUE
+"234756_at",0.918141489589102,0.652414667401767,0.456583777099605,-5.83865297458759,0.34620862024463,"CACNG8","calcium voltage-gated channel auxiliary subunit gamma 8",TRUE
+"215954_s_at",0.839519981963042,0.428056871444346,0.807333112027176,-5.62711269666515,0.275474959847177,"CACTIN","cactin, spliceosome C complex subunit",TRUE
+"213815_x_at",0.88136517545868,0.538005071174629,0.625543327986122,-5.75086984726169,0.200202682167797,"CACTIN","cactin, spliceosome C complex subunit",TRUE
+"240373_at",0.946109039844285,0.755879680400803,-0.314772276038025,-5.89153938346571,-0.241035502733395,"CACTIN","cactin, spliceosome C complex subunit",TRUE
+"237990_x_at",0.960614707352139,0.821059088499303,-0.228883251276676,-5.91419960371888,-0.119901916096558,"CACTIN","cactin, spliceosome C complex subunit",TRUE
+"214892_x_at",0.987211482469658,0.940356177540371,-0.0756757968944029,-5.93689453973392,-0.0243990944301036,"CACTIN","cactin, spliceosome C complex subunit",TRUE
+"1560846_at",0.438531512553085,0.020123924371206,2.50412239564014,-3.27474417323445,1.84462589329086,"CACUL1","CDK2 associated cullin domain 1",TRUE
+"227136_s_at",0.610486790071853,0.0832182541637955,1.81416477263386,-4.45242474091327,1.12623483671161,"CACUL1","CDK2 associated cullin domain 1",TRUE
+"227257_s_at",0.718706241731185,0.194767335429711,1.33706665275473,-5.10454143920439,0.552550755262471,"CACUL1","CDK2 associated cullin domain 1",TRUE
+"227258_at",0.788144775381206,0.314340987231307,1.02952574498287,-5.43621308984413,0.630465630549639,"CACUL1","CDK2 associated cullin domain 1",TRUE
+"225192_at",0.820536502908875,0.379672027455262,0.89640685491843,-5.55570610413533,0.251534034848012,"CACUL1","CDK2 associated cullin domain 1",TRUE
+"227137_at",0.863306144374551,0.487477834390041,0.706111508582469,-5.69971176777968,0.615836616297645,"CACUL1","CDK2 associated cullin domain 1",TRUE
+"201382_at",0.820536502908875,0.379843922003059,0.896077783778453,-5.55598266858485,0.322470783055684,"CACYBP","calcyclin binding protein",TRUE
+"211761_s_at",0.86481525165637,0.492612081623976,-0.697716441273803,-5.7053185814103,-0.199019911575247,"CACYBP","calcyclin binding protein",TRUE
+"210691_s_at",0.939166148226364,0.727744179575281,-0.352567834960977,-5.87932023873695,-0.0979405076595494,"CACYBP","calcyclin binding protein",TRUE
+"201381_x_at",0.968271298107834,0.851038495323041,-0.190000758621488,-5.92211564199471,-0.0452654189661317,"CACYBP","calcyclin binding protein",TRUE
+"1564084_at",0.51470556386048,0.0353123603603175,2.24175503104789,-3.7498828359873,1.19378276715175,"CAD","carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase",TRUE
+"202715_at",0.738414578418269,0.225258651183142,1.24744553833258,-5.20890843330051,0.596301884991027,"CAD","carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase",TRUE
+"209031_at",0.228900728752571,0.00289292004696894,-3.34763258715402,-1.59164299894924,-4.57859638198051,"CADM1","cell adhesion molecule 1",TRUE
+"209032_s_at",0.402463840838386,0.0148540388944011,-2.64149145582212,-3.0149640081016,-2.15082217752763,"CADM1","cell adhesion molecule 1",TRUE
+"209030_s_at",0.568543610339737,0.057989386620834,-1.99927777552033,-4.16040367109233,-2.05672166807949,"CADM1","cell adhesion molecule 1",TRUE
+"244345_at",0.68744166438792,0.156056367979166,-1.46837728425087,-4.94076546433955,-0.986727945955326,"CADM1","cell adhesion molecule 1",TRUE
+"1556259_at",0.912252515563073,0.632375351149623,-0.485088319234823,-5.82571768713447,-0.250282859109906,"CADM1","cell adhesion molecule 1",TRUE
+"232767_at",0.978072252406502,0.893819928452961,0.13501388234393,-5.93080882771826,0.091436309952992,"CADM1","cell adhesion molecule 1",TRUE
+"240433_x_at",0.348854934125219,0.0091530397992569,2.85563422506374,-2.59718881224696,2.14605116585836,"CADM2","cell adhesion molecule 2",TRUE
+"235118_at",0.914242258486146,0.639295014522829,-0.475200631381695,-5.83029150758597,-0.577192792439775,"CADM2","cell adhesion molecule 2",TRUE
+"1552752_a_at",0.944785393058556,0.751577428179037,0.320520077592541,-5.88976946644138,0.118252975253568,"CADM2","cell adhesion molecule 2",TRUE
+"1555544_a_at",0.951879312464239,0.779450096382193,-0.283467752162286,-5.90062163224433,-0.251250116840018,"CADM2","cell adhesion molecule 2",TRUE
+"1552754_a_at",0.969882914559333,0.856797577236292,0.182567451203719,-5.9234622679865,0.193178994023313,"CADM2","cell adhesion molecule 2",TRUE
+"1568871_at",0.989524702314661,0.948550508598365,-0.0652621961253987,-5.93760921665451,-0.0641316472779634,"CADM2-AS1","CADM2 antisense RNA 1",TRUE
+"211677_x_at",0.56861088242915,0.0584114022956552,1.99563966222344,-4.16632991430965,0.938628196996621,"CADM3","cell adhesion molecule 3",TRUE
+"213948_x_at",0.580137756009815,0.0626076404678404,-1.9606792647306,-4.22290640518145,-1.18973657724242,"CADM3","cell adhesion molecule 3",TRUE
+"216535_at",0.660054711393139,0.127975488995045,1.58132187379532,-4.79002493791369,0.832955986193787,"CADM3","cell adhesion molecule 3",TRUE
+"221921_s_at",0.892746695408886,0.56533891886044,0.583667644780284,-5.77510508390359,0.386658228325645,"CADM3","cell adhesion molecule 3",TRUE
+"217442_at",0.728671251879936,0.210144149481304,1.29061150726329,-5.15940800471269,0.514244360637046,"CADM3-AS1","CADM3 antisense RNA 1",TRUE
+"226953_at",0.190498595861526,0.00194274434580721,3.51378958453053,-1.24166890567674,1.53695278069352,"CADM3///ACKR1","cell adhesion molecule 3///atypical chemokine receptor 1 (Duffy blood group)",TRUE
+"222293_at",0.661974206478491,0.129775301782366,1.57349905243462,-4.80075000524723,0.926152323181027,"CADM4","cell adhesion molecule 4",TRUE
+"229335_at",0.750518254904268,0.243474024457924,1.19826628932604,-5.2635358516528,0.543718843903513,"CADM4","cell adhesion molecule 4",TRUE
+"215259_s_at",0.865830945963453,0.495902991730142,0.692361798945095,-5.70886136750809,0.531387486301467,"CADM4","cell adhesion molecule 4",TRUE
+"214267_s_at",0.930520419444084,0.692546194609845,0.400607001294478,-5.8618175450142,0.193765051317319,"CADM4","cell adhesion molecule 4",TRUE
+"215258_at",0.978155972066133,0.893999672247219,0.134783875557894,-5.93083902608554,0.116865667255962,"CADM4","cell adhesion molecule 4",TRUE
+"239884_at",0.700419563774032,0.172097602555836,1.41111848787599,-5.01373436139824,1.10297239185607,"CADPS","calcium dependent secretion activator",TRUE
+"233950_at",0.799786122510766,0.335171457249002,-0.985181856368466,-5.4776917080159,-0.737292837551343,"CADPS","calcium dependent secretion activator",TRUE
+"204814_at",0.956398858120188,0.802152524469406,0.253587501037614,-5.90841054331964,0.197044686520667,"CADPS","calcium dependent secretion activator",TRUE
+"1568603_at",0.957430653957785,0.807284414567617,0.24686661367506,-5.91004384712936,0.270417696047773,"CADPS","calcium dependent secretion activator",TRUE
+"234220_at",0.971242929121865,0.863655283747415,0.17372981137738,-5.92499360134166,0.135496960240933,"CADPS","calcium dependent secretion activator",TRUE
+"1568604_a_at",0.97689149311934,0.89009211649351,0.139785829073223,-5.93017070828126,0.0740909988730438,"CADPS","calcium dependent secretion activator",TRUE
+"219572_at",0.92301310486826,0.670089788231108,-0.43175783603051,-5.84929330876521,-0.366806013508695,"CADPS2","calcium dependent secretion activator 2",TRUE
+"1563787_a_at",0.98539961718117,0.92786866818889,0.0915622033479497,-5.93560094502766,0.0798313271558022,"CAGE1","cancer antigen 1",TRUE
+"235829_at",0.954387719376857,0.789991351489048,0.269562564446168,-5.90435337860846,0.150711302691244,"CAHM","colon adenocarcinoma hypermethylated (non-protein coding)",TRUE
+"205626_s_at",0.00754898684214932,2.48526315790924e-06,6.27687251932215,4.5706059473766,5.73898635477068,"CALB1","calbindin 1",TRUE
+"205625_s_at",0.00894670147697473,3.76358726969216e-06,6.09802829202576,4.21696690605289,7.19888506725799,"CALB1","calbindin 1",TRUE
+"205428_s_at",0.528176582660474,0.0406995215799951,2.17354803495996,-3.8683423024123,2.05197930858331,"CALB2","calbindin 2",TRUE
+"217561_at",0.914910510855952,0.641446510459178,0.472136118317485,-5.83169037582928,0.174325157628621,"CALCA","calcitonin related polypeptide alpha",TRUE
+"210727_at",0.92070400963176,0.662596549338323,0.442248055099637,-5.84486842173032,0.303546869881057,"CALCA","calcitonin related polypeptide alpha",TRUE
+"210728_s_at",0.925511384407886,0.678130047846863,-0.420556279019769,-5.85390304093658,-0.171778772255215,"CALCA","calcitonin related polypeptide alpha",TRUE
+"217495_x_at",0.948429371744093,0.76542198856895,0.302061970880472,-5.89534059246926,0.129606442622389,"CALCA","calcitonin related polypeptide alpha",TRUE
+"214636_at",0.799150634740328,0.333823527148319,0.987992539413626,-5.4751118439514,0.953168575338743,"CALCB","calcitonin related polypeptide beta",TRUE
+"209002_s_at",0.9611086798763,0.822431288462599,0.227096110613349,-5.91459551903083,0.0770478177832246,"CALCOCO1","calcium binding and coiled-coil domain 1",TRUE
+"1560631_at",0.792716268502624,0.324355700290689,1.00795919563051,-5.45659278834816,0.348386688493687,"CALCOCO2","calcium binding and coiled-coil domain 2",TRUE
+"235076_at",0.807944276806637,0.349728288629672,-0.955310529853708,-5.50469551479743,-0.765890906555493,"CALCOCO2","calcium binding and coiled-coil domain 2",TRUE
+"210817_s_at",0.852409445602775,0.458219429103368,-0.754966687310986,-5.66581872216899,-0.375531975249345,"CALCOCO2","calcium binding and coiled-coil domain 2",TRUE
+"238560_at",0.855463536305195,0.468717350838495,-0.737231460608493,-5.67837121418197,-0.254566701005662,"CALCOCO2","calcium binding and coiled-coil domain 2",TRUE
+"207886_s_at",0.622917527985155,0.0936137094982153,-1.75194849566247,-4.54601350970649,-2.40067874107161,"CALCR","calcitonin receptor",TRUE
+"207887_s_at",0.971216837324271,0.862194380790216,0.175611290093204,-5.92467393567368,0.109973286208369,"CALCR","calcitonin receptor",TRUE
+"234996_at",0.767965891104819,0.271065021631289,1.12877902835855,-5.3374483333939,1.24086365385727,"CALCRL","calcitonin receptor like receptor",TRUE
+"210815_s_at",0.90344422113846,0.60452126965247,0.525403776658017,-5.80611720855116,0.58714882004938,"CALCRL","calcitonin receptor like receptor",TRUE
+"206331_at",0.981185098039667,0.911268369334363,-0.112718999369925,-5.93349695883422,-0.130168089961359,"CALCRL","calcitonin receptor like receptor",TRUE
+"231881_at",0.452969693655811,0.0218345877634721,2.46674196903216,-3.3441993376025,1.2920929184328,"CALD1","caldesmon 1",TRUE
+"243084_at",0.481025719247748,0.0272034613056249,2.36490989337932,-3.53053169158196,2.29765148567427,"CALD1","caldesmon 1",TRUE
+"205525_at",0.529951510900133,0.0414268451319098,2.16497583770826,-3.88307079071041,1.90704344203498,"CALD1","caldesmon 1",TRUE
+"215199_at",0.55937703282623,0.0532563778703431,2.04177849788032,-4.09064125847096,1.68461134843416,"CALD1","caldesmon 1",TRUE
+"214880_x_at",0.568731573107512,0.0586884701705231,1.99326377883447,-4.17019615897071,2.47802989997311,"CALD1","caldesmon 1",TRUE
+"201616_s_at",0.597654932724127,0.0750097285091047,1.86824061491089,-4.36917399656622,3.73446450307753,"CALD1","caldesmon 1",TRUE
+"215198_s_at",0.612420348961838,0.0843803960357387,1.80688682192346,-4.46349516141788,1.18343992333622,"CALD1","caldesmon 1",TRUE
+"201617_x_at",0.626983082753167,0.0974640636646131,1.73040554787954,-4.5778589842988,3.65387208968405,"CALD1","caldesmon 1",TRUE
+"212077_at",0.628568991855436,0.0996628182971153,1.71842758040605,-4.59543844378685,3.38316594546327,"CALD1","caldesmon 1",TRUE
+"201615_x_at",0.62986301194198,0.100759776481596,1.71253580231404,-4.60405205239402,1.91558351233147,"CALD1","caldesmon 1",TRUE
+"235834_at",0.643688366500038,0.114381964418877,1.64356801391444,-4.70321664670365,1.71051774526735,"CALD1","caldesmon 1",TRUE
+"1554367_at",0.831875452294783,0.407438355812688,-0.84446007162009,-5.59819604841155,-0.219822923710328,"CALHM1","calcium homeostasis modulator 1",TRUE
+"57715_at",0.723824689174877,0.200751304739787,1.31865991200687,-5.12647695314861,1.16953854749116,"CALHM2","calcium homeostasis modulator 2",TRUE
+"221565_s_at",0.723973974120865,0.200894171581717,1.3182257211392,-5.12699128912598,1.27509037165667,"CALHM2","calcium homeostasis modulator 2",TRUE
+"1554711_at",0.298372619814585,0.00550086146818659,3.07563957548124,-2.15427826929646,1.97142322590213,"CALHM3","calcium homeostasis modulator 3",TRUE
+"213710_s_at",0.812302873476553,0.359621542577614,-0.935488197067892,-5.52219478907271,-0.494562722348192,"CALM1","calmodulin 1",TRUE
+"211985_s_at",0.322131160460075,0.00720484785360683,-2.95962484412423,-2.38939374216733,-1.33215697323737,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"211984_at",0.344817137069397,0.008714101374807,-2.87707838067731,-2.55458288466923,-1.29778230580476,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"213688_at",0.6122079201328,0.0837887858500914,-1.81058088847999,-4.45788016960929,-0.703607317440547,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"241619_at",0.646692716816097,0.117694929560666,1.62784910532712,-4.72538245299592,1.00486816683494,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"200653_s_at",0.762857166457304,0.262651721299836,-1.14938959617261,-5.3159294849591,-0.350751638180292,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"209563_x_at",0.789927874973432,0.318951560579202,-1.01953813008356,-5.4456995579558,-0.282487257727551,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"200655_s_at",0.843424227955276,0.438040683621729,-0.789756634734105,-5.64037668182705,-0.260957237224426,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"200623_s_at",0.910159094731364,0.625804952255293,0.494522532344779,-5.82126781497756,0.150115634377784,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"200622_x_at",0.911885621381855,0.631073217043377,0.486954438422484,-5.82484413270435,0.152882833409526,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"207243_s_at",0.952239474918707,0.781315441409988,0.28100305648679,-5.90129666586217,0.0598376961973184,"CALM3///CALM2///CALM1","calmodulin 3///calmodulin 2///calmodulin 1",TRUE
+"210019_at",0.723649742218726,0.200304073061628,1.32002066696943,-5.12486409747908,1.06686418076447,"CALML3","calmodulin like 3",TRUE
+"210020_x_at",0.961212424803935,0.823346641664346,0.225904383732232,-5.91485781277648,0.0808482418156107,"CALML3","calmodulin like 3",TRUE
+"1566149_at",0.717937808890208,0.193801515345167,-1.34007888295953,-5.1009273974323,-0.701325425622128,"CALML4","calmodulin like 4",TRUE
+"221879_at",0.727286289873957,0.207610586477954,-1.29807966239985,-5.15069841919522,-1.07579415617604,"CALML4","calmodulin like 4",TRUE
+"64408_s_at",0.92051722798026,0.662044063830334,-0.443023496562561,-5.84453719415489,-0.291078840276673,"CALML4","calmodulin like 4",TRUE
+"1568600_at",0.939610295972262,0.729226073530355,-0.350564524711562,-5.88000224765111,-0.155426780048094,"CALML4","calmodulin like 4",TRUE
+"1566150_at",0.946257232656659,0.756389912213743,-0.31409132817759,-5.89174696578105,-0.297640781508886,"CALML4","calmodulin like 4",TRUE
+"220414_at",0.27026056778226,0.0042015817579318,3.19034392701302,-1.91878493603532,4.54714808504137,"CALML5","calmodulin like 5",TRUE
+"1552402_at",0.70573152022539,0.177996914111889,-1.39113632435573,-5.03863770908048,-0.910021539355712,"CALML6","calmodulin like 6",TRUE
+"230698_at",0.623667408398064,0.0952810969129545,1.74252801893695,-4.55997506615481,1.53122125215093,"CALN1","calneuron 1",TRUE
+"1555168_a_at",0.870808709484996,0.510383408226012,0.669037069534116,-5.72398929639489,0.325865283486712,"CALN1","calneuron 1",TRUE
+"223885_at",0.917102138198416,0.649508124487569,-0.460693841803659,-5.83683515408526,-0.325337660241424,"CALN1","calneuron 1",TRUE
+"200935_at",0.42796179417767,0.0185081348729125,2.54225604187379,-3.20333066556856,1.1591826036255,"CALR","calreticulin",TRUE
+"212953_x_at",0.594149510544898,0.0710970197168839,1.89585542636999,-4.32599364611096,0.729441627190432,"CALR","calreticulin",TRUE
+"214315_x_at",0.73759219552868,0.224303283432275,1.25010713060297,-5.20589798715001,0.421785097634466,"CALR","calreticulin",TRUE
+"1552421_a_at",0.927934056345262,0.683752455532386,0.412755699998604,-5.85704281778537,0.236299994284259,"CALR3","calreticulin 3",TRUE
+"200755_s_at",0.571833476034523,0.0599183170407276,1.9828363399183,-4.18712794198269,0.843804879412417,"CALU","calumenin",TRUE
+"214845_s_at",0.603702127972549,0.0777931184090911,1.849351701087,-4.39845194578082,0.8240618959176,"CALU","calumenin",TRUE
+"200756_x_at",0.622917527985155,0.0935451034422193,1.75233917889777,-4.54543329942441,0.764710008321845,"CALU","calumenin",TRUE
+"200757_s_at",0.67606695078322,0.142593623811574,1.52024015364001,-4.87265137412642,0.646135028761089,"CALU","calumenin",TRUE
+"229549_at",0.78969417320323,0.317609028727026,1.02243587544631,-5.4429558146797,0.545661033692687,"CALU","calumenin",TRUE
+"219896_at",0.757479140651,0.253636218368295,1.17202364445276,-5.2919040223144,0.622649423988539,"CALY","calcyon neuron specific vesicular protein",TRUE
+"204392_at",0.646393320658364,0.117444375810154,1.62902482798029,-4.72373019177963,1.03059309368518,"CAMK1","calcium/calmodulin dependent protein kinase I",TRUE
+"1558556_at",0.839026687117702,0.424671530224661,0.813350688631966,-5.62250856822727,0.370788176482415,"CAMK1","calcium/calmodulin dependent protein kinase I",TRUE
+"220246_at",0.835952408568777,0.416252201968381,-0.828447734321403,-5.61081659604193,-0.874184745364634,"CAMK1D","calcium/calmodulin dependent protein kinase ID",TRUE
+"1559991_s_at",0.858246094096012,0.473935594013609,0.728503317472573,-5.68444480451347,0.350435864830357,"CAMK1D","calcium/calmodulin dependent protein kinase ID",TRUE
+"235626_at",0.925269184248693,0.676334085916955,0.423053591422094,-5.85288564634775,0.459377829068626,"CAMK1D","calcium/calmodulin dependent protein kinase ID",TRUE
+"1559990_at",0.966111788889917,0.842210701528967,0.201416340497715,-5.9199433344163,0.103971524743698,"CAMK1D","calcium/calmodulin dependent protein kinase ID",TRUE
+"217128_s_at",0.593339168375633,0.0704706908807222,1.90039877175324,-4.31884685390437,0.619871793806606,"CAMK1G","calcium/calmodulin dependent protein kinase IG",TRUE
+"215161_at",0.782930758690314,0.305449365178827,-1.04908213042615,-5.41739669313644,-0.379032257291617,"CAMK1G","calcium/calmodulin dependent protein kinase IG",TRUE
+"213108_at",0.841550580403629,0.432890827053225,0.79879164171348,-5.63359274868715,0.479032001258123,"CAMK2A","calcium/calmodulin dependent protein kinase II alpha",TRUE
+"207613_s_at",0.909486645831547,0.624156523546252,0.496896578619795,-5.82013485491834,0.308819705078199,"CAMK2A","calcium/calmodulin dependent protein kinase II alpha",TRUE
+"209956_s_at",0.729083413548563,0.210599123348198,-1.2892777753874,-5.16095894874883,-0.874497694783505,"CAMK2B","calcium/calmodulin dependent protein kinase II beta",TRUE
+"210404_x_at",0.82847108093969,0.398519373248342,-0.860889738502409,-5.58501236012089,-0.842123642744464,"CAMK2B","calcium/calmodulin dependent protein kinase II beta",TRUE
+"213276_at",0.906313846447111,0.613036218231914,-0.512988669067188,-5.81231569726878,-0.325511781069148,"CAMK2B","calcium/calmodulin dependent protein kinase II beta",TRUE
+"34846_at",0.913221029035633,0.635946115418036,0.479979898676471,-5.82809222867115,0.139069750861456,"CAMK2B","calcium/calmodulin dependent protein kinase II beta",TRUE
+"211483_x_at",0.952613441433926,0.782984802769493,0.278798822457955,-5.90189540831209,0.171707089426664,"CAMK2B","calcium/calmodulin dependent protein kinase II beta",TRUE
+"225019_at",0.721297082581089,0.19749808255698,-1.32861278002532,-5.11464779280136,-1.23763953935926,"CAMK2D","calcium/calmodulin dependent protein kinase II delta",TRUE
+"224994_at",0.756388854702832,0.251665025509216,-1.17705182083033,-5.28651105811916,-1.05949191440333,"CAMK2D","calcium/calmodulin dependent protein kinase II delta",TRUE
+"228555_at",0.79943091106207,0.334360666074726,-0.986871570186581,-5.47614155859715,-0.903321215832617,"CAMK2D","calcium/calmodulin dependent protein kinase II delta",TRUE
+"231793_s_at",0.811582994401925,0.355760578451412,-0.943179799697507,-5.51544455142783,-1.12874849332017,"CAMK2D","calcium/calmodulin dependent protein kinase II delta",TRUE
+"230749_s_at",0.939976205834042,0.730427492333239,0.348941450083476,-5.88055199248544,0.263015656308036,"CAMK2D","calcium/calmodulin dependent protein kinase II delta",TRUE
+"212757_s_at",0.729273475042162,0.211738043833377,1.28594882978542,-5.16482409710981,0.49568117774057,"CAMK2G","calcium/calmodulin dependent protein kinase II gamma",TRUE
+"212669_at",0.768852835478002,0.272695010200692,1.12484040398252,-5.34152140856964,0.415960098297303,"CAMK2G","calcium/calmodulin dependent protein kinase II gamma",TRUE
+"214322_at",0.802679132489125,0.340448977115005,0.974251445559223,-5.48766084552316,0.395143137843037,"CAMK2G","calcium/calmodulin dependent protein kinase II gamma",TRUE
+"238556_at",0.998384473324293,0.993315116577183,0.00847340139668307,-5.93964851039222,0.00607065494893444,"CAMK2G","calcium/calmodulin dependent protein kinase II gamma",TRUE
+"229163_at",0.942684843065067,0.743354901500867,0.331536267015175,-5.88628864990867,0.202079550665525,"CAMK2N1","calcium/calmodulin dependent protein kinase II inhibitor 1",TRUE
+"228302_x_at",0.954627246077849,0.793256612839642,0.265266410943291,-5.90546866202295,0.334183273988346,"CAMK2N1","calcium/calmodulin dependent protein kinase II inhibitor 1",TRUE
+"218309_at",0.965584868976477,0.839083096384277,0.205467272964822,-5.91914212736568,0.193012669232065,"CAMK2N1","calcium/calmodulin dependent protein kinase II inhibitor 1",TRUE
+"230706_s_at",0.602351341567358,0.0771957174277545,-1.85335564547956,-4.39226344475206,-0.893831362108349,"CAMK2N2","calcium/calmodulin dependent protein kinase II inhibitor 2",TRUE
+"1552893_at",0.750216727961129,0.243142943200205,-1.19913495496998,-5.2625874753835,-0.529839788343486,"CAMK2N2","calcium/calmodulin dependent protein kinase II inhibitor 2",TRUE
+"229029_at",0.415590231477955,0.0168648887730391,2.58437274336063,-3.12382197685476,1.31965156202927,"CAMK4","calcium/calmodulin dependent protein kinase IV",TRUE
+"241871_at",0.627938764248877,0.0993190571576382,1.72028529816415,-4.59271793175097,1.96358421142479,"CAMK4","calcium/calmodulin dependent protein kinase IV",TRUE
+"210349_at",0.663129351367592,0.131011203229104,1.5681792204605,-4.80801965892962,1.39522711547181,"CAMK4","calcium/calmodulin dependent protein kinase IV",TRUE
+"1552768_at",0.248692078473507,0.00344325383455775,3.27444302687845,-1.74442721612266,1.35112721727907,"CAMKK1","calcium/calmodulin dependent protein kinase kinase 1",TRUE
+"223460_at",0.648197684404188,0.119365523715829,1.62006303233014,-4.73630112519589,0.406800901094632,"CAMKK1","calcium/calmodulin dependent protein kinase kinase 1",TRUE
+"207359_at",0.590375215951436,0.0681887423636638,1.91725708715279,-4.29222427180362,0.943793185393093,"CAMKK2","calcium/calmodulin dependent protein kinase kinase 2",TRUE
+"210787_s_at",0.82979599608837,0.401284306629754,0.855771469035897,-5.5891448057327,0.447426965273656,"CAMKK2","calcium/calmodulin dependent protein kinase kinase 2",TRUE
+"213812_s_at",0.961981011884773,0.827171711234364,0.220928003029289,-5.91593825021847,0.112791419171716,"CAMKK2","calcium/calmodulin dependent protein kinase kinase 2",TRUE
+"212252_at",0.993615552413264,0.970040465626724,0.0379841754486966,-5.93898077167432,0.01167741661828,"CAMKK2","calcium/calmodulin dependent protein kinase kinase 2",TRUE
+"219617_at",0.657015752622694,0.125293853771992,-1.59314884572672,-4.77373130902729,-0.522697860329721,"CAMKMT","calmodulin-lysine N-methyltransferase",TRUE
+"1554875_at",0.773234064853267,0.284192579906792,-1.09753481037746,-5.36941201326095,-0.910093725906765,"CAMKMT","calmodulin-lysine N-methyltransferase",TRUE
+"219365_s_at",0.719279614983507,0.195136251102887,1.33591915775043,-5.10591639518662,0.410647087325058,"CAMKV","CaM kinase like vesicle associated",TRUE
+"203538_at",0.728385463227073,0.209767713164209,-1.29171669992407,-5.15812178722605,-0.517908177193545,"CAMLG","calcium modulating ligand",TRUE
+"210244_at",0.837368340567858,0.421062980564968,-0.819798114317524,-5.6175399786192,-0.886340107542383,"CAMP","cathelicidin antimicrobial peptide",TRUE
+"244682_at",0.615637099066718,0.0860829105102237,-1.79637968628717,-4.47942062052747,-1.503562340825,"CAMSAP1","calmodulin regulated spectrin associated protein 1",TRUE
+"212711_at",0.710383535193614,0.183291120373309,-1.3736475221289,-5.06019222638594,-0.4457391415245,"CAMSAP1","calmodulin regulated spectrin associated protein 1",TRUE
+"228995_at",0.765889357241662,0.266103335795633,-1.14087606945235,-5.32485978622916,-0.713565584012023,"CAMSAP1","calmodulin regulated spectrin associated protein 1",TRUE
+"220410_s_at",0.775341201891078,0.29181184526871,1.07987773948426,-5.38712268839839,0.581534557010936,"CAMSAP1","calmodulin regulated spectrin associated protein 1",TRUE
+"212712_at",0.888750194607196,0.55528253065937,-0.598948044759124,-5.76644948320535,-0.1711157775622,"CAMSAP1","calmodulin regulated spectrin associated protein 1",TRUE
+"220409_at",0.954387719376857,0.790118920922782,0.269394622632064,-5.90439731057075,0.192547619821239,"CAMSAP1","calmodulin regulated spectrin associated protein 1",TRUE
+"212710_at",0.961212424803935,0.823622947005244,-0.225544718995138,-5.91493670360398,-0.0584586743880582,"CAMSAP1","calmodulin regulated spectrin associated protein 1",TRUE
+"212763_at",0.931209631927021,0.695222325259583,0.396922108760666,-5.86323803827359,0.113346077371101,"CAMSAP2","calmodulin regulated spectrin associated protein family member 2",TRUE
+"212765_at",0.960364513710223,0.820171465013479,0.230039689725693,-5.91394176590309,0.0934181398848679,"CAMSAP2","calmodulin regulated spectrin associated protein family member 2",TRUE
+"217196_s_at",0.98055399787159,0.909121961776071,-0.115458200805193,-5.93319272392457,-0.0424078916900665,"CAMSAP2","calmodulin regulated spectrin associated protein family member 2",TRUE
+"1568617_a_at",0.957571530817866,0.809307235580967,-0.244220670180284,-5.91067489749587,-0.176345967193656,"CAMSAP3","calmodulin regulated spectrin associated protein family member 3",TRUE
+"226494_at",0.978928101156583,0.897367934124228,0.130475086215136,-5.93139524071421,0.11185524980675,"CAMSAP3","calmodulin regulated spectrin associated protein family member 3",TRUE
+"1555370_a_at",0.853093296743962,0.459526641751794,0.752745155129522,-5.66740654236703,0.534680185605807,"CAMTA1","calmodulin binding transcription activator 1",TRUE
+"241882_at",0.862388151566272,0.485334273394409,0.709631544201059,-5.69734182611012,0.412650331067502,"CAMTA1","calmodulin binding transcription activator 1",TRUE
+"225693_s_at",0.901409056707901,0.598087176043759,0.534840580826458,-5.80130917118409,0.141963135548625,"CAMTA1","calmodulin binding transcription activator 1",TRUE
+"227328_at",0.94149227422279,0.73839154280292,0.338206182753499,-5.88412457937577,0.14219056021455,"CAMTA1","calmodulin binding transcription activator 1",TRUE
+"213268_at",0.992995543650699,0.96657014783887,0.0423866271447995,-5.93880844827342,0.0356269929709736,"CAMTA1","calmodulin binding transcription activator 1",TRUE
+"225692_at",0.994050962712312,0.972217784679168,0.035222422775402,-5.93907923900857,0.00936414833051558,"CAMTA1","calmodulin binding transcription activator 1",TRUE
+"212948_at",0.949996193051765,0.772976326297099,0.292035634934417,-5.89822955019907,0.0851293934264952,"CAMTA2","calmodulin binding transcription activator 2",TRUE
+"208839_s_at",0.640987277293074,0.111438366315376,-1.65785895367922,-4.68292294934311,-0.638324916964379,"CAND1","cullin associated and neddylation dissociated 1",TRUE
+"235224_s_at",0.657571067962164,0.126335414011321,-1.58853040828789,-4.78010525216909,-0.974934093257617,"CAND1","cullin associated and neddylation dissociated 1",TRUE
+"208838_at",0.687545925823023,0.156557817159294,-1.46651699341758,-4.94317325572453,-0.596172142599212,"CAND1","cullin associated and neddylation dissociated 1",TRUE
+"239771_at",0.756313947022433,0.251497045426693,-1.1774816643661,-5.28604909369878,-0.398818090676864,"CAND1","cullin associated and neddylation dissociated 1",TRUE
+"207483_s_at",0.833057833553471,0.410167661257603,-0.839478383104321,-5.60214668623874,-0.252768695873888,"CAND1","cullin associated and neddylation dissociated 1",TRUE
+"1556318_s_at",0.849646596450765,0.450993912657554,0.76731528932459,-5.6569120186635,0.317426567545334,"CAND1","cullin associated and neddylation dissociated 1",TRUE
+"243910_x_at",0.906476756086155,0.613643902660898,-0.51210577993557,-5.8127509952332,-0.180604793005752,"CAND1","cullin associated and neddylation dissociated 1",TRUE
+"237915_at",0.731054546207485,0.213946287835995,1.27953355809861,-5.17224869614492,0.45893454941612,"CAND1.11","uncharacterized LOC100130460",TRUE
+"209491_s_at",0.822600785740588,0.387650679709427,0.881234412451846,-5.56835981453889,0.507586766545704,"CAND1.11///AMPD3","uncharacterized LOC100130460///adenosine monophosphate deaminase 3",TRUE
+"213547_at",0.595419021493991,0.0721102310163305,1.88857934441628,-4.33741416723523,1.46269452476053,"CAND2","cullin associated and neddylation dissociated 2 (putative)",TRUE
+"234404_at",0.679862743105294,0.147064763955174,1.50258858671183,-4.89604698210885,0.807987334948995,"CAND2","cullin associated and neddylation dissociated 2 (putative)",TRUE
+"221732_at",0.895690630367785,0.576321144285972,0.567139044230039,-5.78422393258957,0.283539452973015,"CANT1","calcium activated nucleotidase 1",TRUE
+"46323_at",0.943294768503521,0.745091059766967,0.329206795583343,-5.88703440427881,0.134626696688484,"CANT1","calcium activated nucleotidase 1",TRUE
+"1554327_a_at",0.954723352940649,0.794171383216885,0.264063751418371,-5.90577768479311,0.144770299440792,"CANT1","calcium activated nucleotidase 1",TRUE
+"238138_at",0.195828721931222,0.00212035854381863,3.47740890680369,-1.31863195256803,2.48552009295891,"CANX","calnexin",TRUE
+"200068_s_at",0.943090724841892,0.744502640432112,-0.329996092039188,-5.88678230263658,-0.0781514936536762,"CANX","calnexin",TRUE
+"238034_at",0.964685626382167,0.836669540214056,-0.208595758444609,-5.91851249157583,-0.0732443044759457,"CANX","calnexin",TRUE
+"208852_s_at",0.981215182293986,0.911368095151998,0.112591752959962,-5.93351091438954,0.0336004929136653,"CANX","calnexin",TRUE
+"208853_s_at",0.981335195954425,0.911584801058454,0.112315250897736,-5.93354118505524,0.0432480099729613,"CANX","calnexin",TRUE
+"213798_s_at",0.649010621432137,0.119842912372727,1.61785485698995,-4.73939036803901,0.41936167683277,"CAP1","adenylate cyclase associated protein 1",TRUE
+"200625_s_at",0.879111461403304,0.532756820523769,0.633711925013959,-5.74595379101554,0.170564828622823,"CAP1","adenylate cyclase associated protein 1",TRUE
+"212551_at",0.7717895132349,0.281744800671712,-1.10327986578346,-5.36359440575758,-0.554545232848868,"CAP2","CAP, adenylate cyclase-associated protein, 2 (yeast)",TRUE
+"212554_at",0.863408882018863,0.488009987377898,-0.705239022329793,-5.70029745175148,-0.383948700618243,"CAP2","CAP, adenylate cyclase-associated protein, 2 (yeast)",TRUE
+"201850_at",0.462926905857638,0.0234996748815056,2.43288553330519,-3.40662539750496,2.32264251491047,"CAPG","capping actin protein, gelsolin like",TRUE
+"200752_s_at",0.720785622687755,0.196812745296119,1.33072581038777,-5.1121267808027,0.931458308478591,"CAPN1","calpain 1",TRUE
+"232012_at",0.88440457468396,0.543624579113084,0.616844140373729,-5.75603768101619,0.26482539607415,"CAPN1","calpain 1",TRUE
+"219333_s_at",0.688234475234403,0.157590777587948,-1.46270005183921,-4.94810581475025,-0.478524447900211,"CAPN10","calpain 10",TRUE
+"221040_at",0.832758870942732,0.409624454963582,-0.840468190775112,-5.60136347472683,-0.759135867355958,"CAPN10","calpain 10",TRUE
+"232571_at",0.880919548823832,0.536836589048214,0.62735827755185,-5.74978287215175,0.215982546765393,"CAPN10-AS1","CAPN10 antisense RNA 1 (head to head)",TRUE
+"207962_at",0.991363846997029,0.95949236341042,0.0513682756493736,-5.93839834911364,0.0308230586958276,"CAPN11","calpain 11",TRUE
+"228705_at",0.859502367311367,0.477321256560904,0.722870576649403,-5.6883279345332,0.506393987350261,"CAPN12","calpain 12",TRUE
+"1552801_at",0.673366993714442,0.139645409010705,-1.53212928525971,-4.85677067390133,-0.994934105690169,"CAPN13","calpain 13",TRUE
+"234709_at",0.89316156038085,0.567160509492953,-0.580914835423984,-5.77664141457344,-0.671066079937846,"CAPN13","calpain 13",TRUE
+"229499_at",0.913342687538603,0.63675671916694,-0.478822036667373,-5.82862701884799,-0.344922295612169,"CAPN13","calpain 13",TRUE
+"1557321_a_at",0.30514766112199,0.00606109483271113,3.03408299348732,-2.2388720121966,2.00717637962952,"CAPN14","calpain 14",TRUE
+"230295_at",0.984473578298083,0.924279598419849,0.0961324454435828,-5.93518331480663,0.0567164583963438,"CAPN15","calpain 15",TRUE
+"204275_at",0.990605394412423,0.952296552189633,-0.0605041450339014,-5.93790062091577,-0.0205332350709835,"CAPN15","calpain 15",TRUE
+"214888_at",0.702809964629668,0.174562551765344,1.40270376509466,-5.02425716974599,0.731462696592359,"CAPN2","calpain 2",TRUE
+"208683_at",0.832830355420594,0.409964264943573,0.839848905706469,-5.60185360136677,0.822003997296727,"CAPN2","calpain 2",TRUE
+"210944_s_at",0.736127479258125,0.221464305556779,1.25806780682158,-5.19686105043616,0.418551834561486,"CAPN3","calpain 3",TRUE
+"211890_x_at",0.851323861236999,0.455409607562136,0.759754719425424,-5.66238146641865,0.249940673377066,"CAPN3","calpain 3",TRUE
+"214475_x_at",0.968680443465534,0.852562809693735,0.188032261382609,-5.92247747025438,0.0560675008116411,"CAPN3","calpain 3",TRUE
+"226292_at",0.839519981963042,0.426978733791228,0.809246314849504,-5.62565235866795,0.448464250034536,"CAPN5","calpain 5",TRUE
+"205166_at",0.968035667633768,0.849357239098804,-0.192172821960192,-5.92171203876511,-0.105775575048502,"CAPN5","calpain 5",TRUE
+"217387_at",0.724623760403195,0.202038523609987,1.31475654455687,-5.13109568744779,1.15802503276768,"CAPN6","calpain 6",TRUE
+"202965_s_at",0.864894115958506,0.493703247471086,-0.695938743811834,-5.70649764567007,-0.913213675881856,"CAPN6","calpain 6",TRUE
+"202966_at",0.904092974845832,0.606259970227137,-0.522861949296081,-5.80739802062362,-0.546379754658682,"CAPN6","calpain 6",TRUE
+"203357_s_at",0.643082025527735,0.113479221882484,-1.64791751160821,-4.69705441206498,-0.584403517717048,"CAPN7","calpain 7",TRUE
+"203356_at",0.657015752622694,0.125875863525871,-1.59056420312046,-4.77730017297709,-0.596392808460102,"CAPN7","calpain 7",TRUE
+"229030_at",0.987540154487264,0.941373668252797,-0.0743822969832049,-5.93698905310477,-0.0686640475962417,"CAPN8","calpain 8",TRUE
+"208063_s_at",0.783297012796639,0.305869066725345,-1.04815004652749,-5.41830073714585,-1.12670124803442,"CAPN9","calpain 9",TRUE
+"210641_at",0.992031007642741,0.96308589333709,0.0468076229819404,-5.93861640438667,0.0200942563450344,"CAPN9","calpain 9",TRUE
+"200001_at",0.398650588126476,0.0139241045721114,-2.67041110260633,-2.95941261428318,-0.925552209864209,"CAPNS1","calpain small subunit 1",TRUE
+"223832_s_at",0.947778780715578,0.762004661368061,0.30660788733996,-5.8939988986396,0.118894454233004,"CAPNS2","calpain small subunit 2",TRUE
+"226990_at",0.650490742096872,0.120592608295324,1.61440192740787,-4.74421449622311,0.664690611857433,"CAPRIN1","cell cycle associated protein 1",TRUE
+"243370_at",0.67842163564685,0.145806058696117,1.50751289114014,-4.88954222078301,0.645219554287192,"CAPRIN1","cell cycle associated protein 1",TRUE
+"200722_s_at",0.853170381292938,0.459658709131158,0.752520924860884,-5.66756656284424,0.255632646124356,"CAPRIN1","cell cycle associated protein 1",TRUE
+"236850_at",0.854441425534558,0.466000710891907,0.741798107431871,-5.67516610725577,0.270933142028039,"CAPRIN1","cell cycle associated protein 1",TRUE
+"226289_at",0.896229101808264,0.579924315729345,-0.561750964772695,-5.78714167075061,-0.200196854650027,"CAPRIN1","cell cycle associated protein 1",TRUE
+"225340_s_at",0.906476756086155,0.613858559446998,-0.511794009149467,-5.81290453544233,-0.145993322189044,"CAPRIN1","cell cycle associated protein 1",TRUE
+"200723_s_at",0.937257436560633,0.721637020569825,0.360839491686213,-5.87646357762178,0.0984552026703494,"CAPRIN1","cell cycle associated protein 1",TRUE
+"226285_at",0.954577684533304,0.791762571870671,-0.26723150520317,-5.9049607308332,-0.102379072222787,"CAPRIN1","cell cycle associated protein 1",TRUE
+"218456_at",0.698391916012681,0.169391108531486,1.420469521476,-5.00197995553746,0.867572737775999,"CAPRIN2","caprin family member 2",TRUE
+"1555608_at",0.844245372791972,0.441014944532446,0.784568278748878,-5.64423951894111,0.538869386507021,"CAPRIN2","caprin family member 2",TRUE
+"231710_at",0.762469810007018,0.261929319592018,1.15118185282058,-5.31404204793872,0.676698662440322,"CAPS","calcyphosine",TRUE
+"231728_at",0.886783047600321,0.55028933193381,0.606588620296369,-5.76204044312377,0.858087327271999,"CAPS","calcyphosine",TRUE
+"226424_at",0.931941664456949,0.699173573559389,0.391491635892856,-5.86530786843516,0.668868186068769,"CAPS","calcyphosine",TRUE
+"231729_s_at",0.936992192746977,0.717812479350496,0.366032581677831,-5.87463669026463,0.657504372319887,"CAPS","calcyphosine",TRUE
+"224370_s_at",0.56861088242915,0.0584262698829316,1.9955119176163,-4.16653787013029,2.2240799006539,"CAPS2","calcyphosine 2",TRUE
+"1560458_s_at",0.975449397348071,0.882711783041739,0.149243269000553,-5.92884067357034,0.160052367461151,"CAPS2","calcyphosine 2",TRUE
+"236085_at",0.98529096111871,0.926800161101202,0.0929226032840303,-5.9354787553897,0.0844414931366533,"CAPSL","calcyphosine like",TRUE
+"241275_at",0.804779510162821,0.343829624629023,0.967310575389855,-5.49393863645774,0.63116233669079,"CAPZA1","capping actin protein of muscle Z-line alpha subunit 1",TRUE
+"208374_s_at",0.887083096014278,0.551422670945255,-0.604851208216327,-5.7630477666722,-0.169065973651707,"CAPZA1","capping actin protein of muscle Z-line alpha subunit 1",TRUE
+"1569450_at",0.770957614026379,0.279475062362371,1.10863947641446,-5.35814278800475,0.702416423803808,"CAPZA2","capping actin protein of muscle Z-line alpha subunit 2",TRUE
+"201237_at",0.861709844431588,0.483928683553213,0.71194460969724,-5.69577839246551,0.248710143670014,"CAPZA2","capping actin protein of muscle Z-line alpha subunit 2",TRUE
+"201238_s_at",0.967737940016834,0.848301117637339,-0.193537738943613,-5.92145607701095,-0.0507259287391246,"CAPZA2","capping actin protein of muscle Z-line alpha subunit 2",TRUE
+"236888_at",0.888830748858811,0.556122745088451,0.5976658909588,-5.76718406894304,0.453404976466034,"CAPZA3","capping actin protein of muscle Z-line alpha subunit 3",TRUE
+"215097_at",0.734203380012717,0.218551793295078,1.26631631238157,-5.18744553620386,0.882090555929295,"CAPZB","capping actin protein of muscle Z-line beta subunit",TRUE
+"201949_x_at",0.921980251030053,0.667148663425847,-0.435869353119838,-5.84757145337683,-0.121852580936201,"CAPZB","capping actin protein of muscle Z-line beta subunit",TRUE
+"201950_x_at",0.926351454466966,0.68000211476967,-0.417956032792553,-5.85495607725871,-0.122707852514141,"CAPZB","capping actin protein of muscle Z-line beta subunit",TRUE
+"37012_at",0.951810226174863,0.77879548211132,-0.284333123815126,-5.90038323584199,-0.0776229719802775,"CAPZB","capping actin protein of muscle Z-line beta subunit",TRUE
+"210026_s_at",0.51470556386048,0.0351205370730679,2.24435430450604,-3.74532470831653,1.3366791984446,"CARD10","caspase recruitment domain family member 10",TRUE
+"210025_s_at",0.528176582660474,0.040781756640204,2.17257189601137,-3.87002129745634,1.7161301049767,"CARD10","caspase recruitment domain family member 10",TRUE
+"214207_s_at",0.828068961116677,0.397799778277766,0.862225550748013,-5.58393006267785,0.678717740313419,"CARD10","caspase recruitment domain family member 10",TRUE
+"223514_at",0.0595361125571683,0.000131193641440467,4.61809016922611,1.13348027467277,2.7676401474691,"CARD11","caspase recruitment domain family member 11",TRUE
+"1562368_at",0.384586587899771,0.0125621082008154,2.71623787600478,-2.87080648402025,1.21113802411203,"CARD11","caspase recruitment domain family member 11",TRUE
+"220599_s_at",0.62110896023334,0.0911242692778837,-1.76628471953363,-4.52466016498031,-1.09006810848302,"CARD14","caspase recruitment domain family member 14",TRUE
+"220598_at",0.635916735157933,0.107082298624201,-1.67960302817188,-4.65178906942969,-1.82489004974639,"CARD14","caspase recruitment domain family member 14",TRUE
+"1555309_a_at",0.733460868923447,0.217777846293612,-1.26852237759674,-5.18491843266267,-1.09820167842151,"CARD14","caspase recruitment domain family member 14",TRUE
+"224113_at",0.788413816943444,0.314583953978766,-1.02899686373578,-5.43671752681976,-0.59157784001074,"CARD14","caspase recruitment domain family member 14",TRUE
+"232608_x_at",0.895213601869362,0.572868854620336,-0.572317457469034,-5.7813942910752,-0.53936586217344,"CARD14","caspase recruitment domain family member 14",TRUE
+"1555308_at",0.993474831312851,0.969421882607652,0.0387688521246869,-5.93895143974133,0.0222885745768435,"CARD14","caspase recruitment domain family member 14",TRUE
+"1554744_at",0.40221114169538,0.0144481586144477,-2.65389782076225,-2.9911679615756,-2.00460225402345,"CARD16","caspase recruitment domain family member 16",TRUE
+"1552701_a_at",0.608709711882903,0.0813698438262947,1.82592382985682,-4.43447041072917,2.18672901103966,"CARD16","caspase recruitment domain family member 16",TRUE
+"1552703_s_at",0.54775309185967,0.048137527669491,2.09172081604325,-4.00743605242525,2.5744131039967,"CARD16///CASP1","caspase recruitment domain family member 16///caspase 1",TRUE
+"231733_at",0.981944022360435,0.913557285382533,0.109798904014196,-5.93381325079725,0.065810392741076,"CARD18","caspase recruitment domain family member 18",TRUE
+"223398_at",0.627833079574546,0.0991833531557764,-1.7210201647684,-4.59164115974558,-1.02604595032009,"CARD19","caspase recruitment domain family member 19",TRUE
+"1562559_at",0.923376218980614,0.670925048666387,0.430591572675137,-5.84977880828598,0.173360648703224,"CARD19","caspase recruitment domain family member 19",TRUE
+"224414_s_at",0.0863239677440823,0.00032208668348958,4.2516042422862,0.342708315131357,4.4502035010976,"CARD6","caspase recruitment domain family member 6",TRUE
+"232969_at",0.755049574909504,0.248994347294072,1.18391132059454,-5.27912139153192,0.890227501782848,"CARD8","caspase recruitment domain family member 8",TRUE
+"1554479_a_at",0.877857073443889,0.52906690044246,-0.639481137780704,-5.74244477813767,-0.260333348257459,"CARD8","caspase recruitment domain family member 8",TRUE
+"204950_at",0.91876780831279,0.654774991262784,-0.453251975199013,-5.84011486316431,-0.127513206912617,"CARD8","caspase recruitment domain family member 8",TRUE
+"228641_at",0.93667390723462,0.717240429912652,-0.366810208411866,-5.87436090902259,-0.157833080698065,"CARD8","caspase recruitment domain family member 8",TRUE
+"1569004_at",0.653418120885392,0.122807948975186,1.60430239169648,-4.75827884627743,0.99728326117592,"CARD8-AS1","CARD8 antisense RNA 1",TRUE
+"242521_at",0.67842163564685,0.145701433609987,1.50792376803715,-4.88899870289125,1.01439077057933,"CARD8-AS1","CARD8 antisense RNA 1",TRUE
+"219834_at",0.536559328842429,0.0434491634106056,-2.14183688893621,-3.92264584898944,-1.31357030730443,"CARF","calcium responsive transcription factor",TRUE
+"1555391_a_at",0.869793539734051,0.507545947820314,0.673577919362253,-5.72108306984287,0.441220473740243,"CARF","calcium responsive transcription factor",TRUE
+"218384_at",0.747359606523751,0.239163245251815,1.20964683984768,-5.2510636915062,0.435608459997718,"CARHSP1","calcium regulated heat stable protein 1",TRUE
+"1566135_at",0.812302873476553,0.359853249365334,-0.935028372712192,-5.52259672811344,-0.608974378994787,"CARHSP1","calcium regulated heat stable protein 1",TRUE
+"1566134_at",0.932091525948902,0.700288642083322,0.389961293013017,-5.86588608616018,0.234209249292485,"CARHSP1","calcium regulated heat stable protein 1",TRUE
+"224910_at",0.945498722604777,0.754362840880845,0.316797526256099,-5.89091936834407,0.11604681199227,"CARHSP1","calcium regulated heat stable protein 1",TRUE
+"212512_s_at",0.708412871463647,0.180371569888348,1.3832415615991,-5.0483958153849,0.652160606426513,"CARM1","coactivator associated arginine methyltransferase 1",TRUE
+"230793_at",0.606312240108248,0.0799670591924798,1.83500352023871,-4.4205501015942,0.771157338362274,"CARMIL1","capping protein regulator and myosin 1 linker 1",TRUE
+"219573_at",0.623667408398064,0.0953453103093309,1.7421680541417,-4.56050744489468,0.585378320612454,"CARMIL1","capping protein regulator and myosin 1 linker 1",TRUE
+"1558931_at",0.784918343662568,0.309483394044381,1.04016048739774,-5.42602029473658,0.653503271333952,"CARMIL1","capping protein regulator and myosin 1 linker 1",TRUE
+"1562939_at",0.900867933475689,0.596859907044242,0.53664616927532,-5.80037973621706,0.231739720467602,"CARMIL1","capping protein regulator and myosin 1 linker 1",TRUE
+"227218_at",0.52645337190204,0.0397475906577343,2.1849794982882,-3.84864504468329,1.33286069154306,"CARMIL2","capping protein regulator and myosin 1 linker 2",TRUE
+"227216_at",0.707898177720919,0.179801349886746,1.38512974250311,-5.04606616799141,0.824637894268705,"CARMIL2","capping protein regulator and myosin 1 linker 2",TRUE
+"229561_at",0.809930331505913,0.353641654635594,0.947424927533009,-5.511697264247,0.55480788547213,"CARMIL3","capping protein regulator and myosin 1 linker 3",TRUE
+"231987_at",0.65284137151906,0.12172983690738,1.6091982220946,-4.75146958223745,0.533796237289226,"CARMN","cardiac mesoderm enhancer-associated non-coding RNA",TRUE
+"1558828_s_at",0.83176290176151,0.406548363725187,-0.846089130474774,-5.59689941917758,-0.773607993209154,"CARMN","cardiac mesoderm enhancer-associated non-coding RNA",TRUE
+"227183_at",0.697172073261335,0.167317937621173,-1.42771371576583,-4.9928300918912,-0.797941206222322,"CARMN///MIR145","cardiac mesoderm enhancer-associated non-coding RNA///microRNA 145",TRUE
+"241781_at",0.864079461576774,0.491145338994917,0.700109577346698,-5.70372679390119,0.293593399334743,"CARNMT1","carnosine N-methyltransferase 1",TRUE
+"228324_at",0.995113346376719,0.977586247107203,0.028414116864834,-5.93929025211878,0.00960815989436092,"CARNMT1","carnosine N-methyltransferase 1",TRUE
+"228984_at",0.93565329131222,0.713426568865437,-0.372000576869108,-5.87250537765121,-0.239592978329195,"CARNS1","carnosine synthase 1",TRUE
+"240982_at",0.619415519928971,0.0896130882482748,1.77515224516838,-4.5113883235844,0.980006627581067,"CARS","cysteinyl-tRNA synthetase",TRUE
+"240983_s_at",0.697172073261335,0.167003120190905,-1.4288200600241,-4.9914293539024,-0.460061374900818,"CARS","cysteinyl-tRNA synthetase",TRUE
+"212971_at",0.76029267756668,0.258814548595291,-1.15895160202505,-5.30582980257556,-0.303493944358586,"CARS","cysteinyl-tRNA synthetase",TRUE
+"202402_s_at",0.876278327062923,0.524855366722103,-0.646092710559026,-5.73838583519091,-0.190270177467838,"CARS","cysteinyl-tRNA synthetase",TRUE
+"1562436_at",0.728385463227073,0.209759881342607,-1.2917397099335,-5.15809499835395,-0.702366587746213,"CARS-AS1","CARS antisense RNA 1",TRUE
+"237555_at",0.399312926596283,0.0141663410835658,2.66270656746229,-2.97424016521969,1.84250927521728,"CARS2","cysteinyl-tRNA synthetase 2, mitochondrial (putative)",TRUE
+"231023_at",0.429276772897071,0.0187842189972076,2.53552545208744,-3.21597544060661,0.687015532809236,"CARS2","cysteinyl-tRNA synthetase 2, mitochondrial (putative)",TRUE
+"218153_at",0.612280302313181,0.0838553442648899,1.81016416769507,-4.45851400109957,0.800196039215907,"CARS2","cysteinyl-tRNA synthetase 2, mitochondrial (putative)",TRUE
+"1557179_s_at",0.705559553212919,0.17747895563115,-1.39286943906561,-5.03648938590065,-0.996361164372789,"CARS2","cysteinyl-tRNA synthetase 2, mitochondrial (putative)",TRUE
+"244817_at",0.813115693594474,0.362976035364615,0.928850452265748,-5.52797932139431,0.813191160968531,"CARS2","cysteinyl-tRNA synthetase 2, mitochondrial (putative)",TRUE
+"206339_at",0.819018525257656,0.373704887152294,0.907891568476911,-5.54599510269113,0.859431670551136,"CARTPT","CART prepropeptide",TRUE
+"220168_at",0.902591244881539,0.601793529783477,0.529398573292335,-5.8040920334218,0.358810655328184,"CASC1","cancer susceptibility candidate 1",TRUE
+"1555922_at",0.955904644595647,0.800505724793021,-0.255746719749,-5.90787655839479,-0.193966226557331,"CASC10","cancer susceptibility candidate 10",TRUE
+"239503_at",0.991399575197268,0.960071213720462,0.0506335671421385,-5.93843484583861,0.0422282282135802,"CASC10","cancer susceptibility candidate 10",TRUE
+"1555923_a_at",0.997325121479245,0.986465745108402,-0.0171559640263459,-5.93954012588638,-0.0133518587692407,"CASC10","cancer susceptibility candidate 10",TRUE
+"1561232_at",0.990623482682449,0.952589660060812,0.0601319148195572,-5.93792248835202,0.0462970446990933,"CASC11","cancer susceptibility candidate 11 (non-protein coding)",TRUE
+"229280_s_at",0.749701891366977,0.24261957504979,1.20050994250277,-5.26108509485125,1.0530199530055,"CASC15","cancer susceptibility candidate 15 (non-protein coding)",TRUE
+"241047_at",0.87538158011492,0.522683256779729,0.649513987031903,-5.73626971913857,0.574209032311296,"CASC15","cancer susceptibility candidate 15 (non-protein coding)",TRUE
+"1562469_at",0.906878681039516,0.615251045556447,-0.50977278664153,-5.81389773113892,-0.311658375007941,"CASC15","cancer susceptibility candidate 15 (non-protein coding)",TRUE
+"241671_x_at",0.915016020278237,0.642009045631709,-0.471335620756552,-5.83205432253026,-0.348253253493566,"CASC15","cancer susceptibility candidate 15 (non-protein coding)",TRUE
+"238211_at",0.830635993561085,0.403869514768414,-0.851006328569431,-5.5929715007343,-0.502988121866896,"CASC16","cancer susceptibility candidate 16 (non-protein coding)",TRUE
+"1557875_at",0.895213601869362,0.572829445593303,0.572376661843726,-5.7813617959214,0.192924271084391,"CASC17","cancer susceptibility candidate 17 (non-protein coding)",TRUE
+"233190_at",0.820536502908875,0.380297366489633,0.895210188844946,-5.55671137943178,0.649345609484533,"CASC18","cancer susceptibility candidate 18 (non-protein coding)",TRUE
+"1564372_s_at",0.657015752622694,0.125918650229282,1.59037458485872,-4.77756181925461,0.545528231031765,"CASC2","cancer susceptibility candidate 2 (non-protein coding)",TRUE
+"239713_at",0.713330901550199,0.188195211911792,1.35780078472824,-5.07952695574538,0.783198946532762,"CASC2","cancer susceptibility candidate 2 (non-protein coding)",TRUE
+"1564371_a_at",0.841420204214686,0.432300380415773,-0.799831764716998,-5.6328071146796,-0.635613566230912,"CASC2","cancer susceptibility candidate 2 (non-protein coding)",TRUE
+"1562336_at",0.906476756086155,0.613605365418009,-0.512161757457575,-5.81272341788921,-0.331900715890336,"CASC2","cancer susceptibility candidate 2 (non-protein coding)",TRUE
+"1556630_at",0.97689149311934,0.889986083807443,-0.139921608884418,-5.93015222771736,-0.132025414929614,"CASC2","cancer susceptibility candidate 2 (non-protein coding)",TRUE
+"1556954_at",0.358427723880268,0.0100503796935368,-2.81468617838924,-2.67817676935724,-1.83904490429391,"CASC22","cancer susceptibility candidate 22 (non-protein coding)",TRUE
+"1557330_at",0.593339168375633,0.070087159299121,1.9031983824503,-4.31443705486332,1.42868324135119,"CASC23","cancer susceptibility candidate 23 (non-protein coding)",TRUE
+"1552719_at",0.727286289873957,0.207526073469619,1.29832999450277,-5.15040573560044,1.1029252828827,"CASC4","cancer susceptibility candidate 4",TRUE
+"224619_at",0.861659105448003,0.48293789670079,-0.713577408535363,-5.6946718439371,-0.253001636854522,"CASC4","cancer susceptibility candidate 4",TRUE
+"1559635_at",0.983498417373669,0.919229383118859,0.102566855477454,-5.93456089480202,0.0620889491682588,"CASC4","cancer susceptibility candidate 4",TRUE
+"1561476_at",0.919375181609246,0.657201430930247,0.449832267362033,-5.84160440555586,0.265875590447689,"CASC6","cancer susceptibility candidate 6 (non-protein coding)",TRUE
+"243304_at",0.969165731345074,0.853947125881096,-0.186245216312701,-5.92280269374302,-0.0541533842716353,"CASC7","cancer susceptibility candidate 7 (non-protein coding)",TRUE
+"1561042_at",0.776211834571297,0.293746667930767,1.07544684442221,-5.39152680044196,0.394054715395557,"CASC7///AGO2","cancer susceptibility candidate 7 (non-protein coding)///argonaute 2, RISC catalytic component",TRUE
+"225569_at",0.778868437679472,0.299799721820529,1.0617184394367,-5.40506935429677,0.327918675411299,"CASC7///AGO2","cancer susceptibility candidate 7 (non-protein coding)///argonaute 2, RISC catalytic component",TRUE
+"213310_at",0.796969171415842,0.329987464772421,0.996034531600576,-5.46769336872581,0.348438918925433,"CASC7///AGO2","cancer susceptibility candidate 7 (non-protein coding)///argonaute 2, RISC catalytic component",TRUE
+"219342_at",0.704449222279154,0.17638834716548,-1.39653187260785,-5.03194225510816,-0.741980437022168,"CASD1","CAS1 domain containing 1",TRUE
+"242000_at",0.867087759460417,0.498747952334386,-0.68774907731367,-5.71189238258412,-0.4970064319151,"CASD1","CAS1 domain containing 1",TRUE
+"231244_at",0.870084233343568,0.508265970567454,0.672424307414936,-5.72182318567269,0.595763980842084,"CASD1","CAS1 domain containing 1",TRUE
+"227156_at",0.932091525948902,0.70054289925682,-0.389612478076113,-5.8660175684887,-0.186865271410252,"CASK","calcium/calmodulin dependent serine protein kinase",TRUE
+"238699_s_at",0.937941197043043,0.725553199082003,0.355532428975118,-5.87830392401793,0.18501645522595,"CASK","calcium/calmodulin dependent serine protein kinase",TRUE
+"207620_s_at",0.94895689004559,0.769466098048987,-0.296690647143561,-5.89690029332292,-0.146168506753849,"CASK","calcium/calmodulin dependent serine protein kinase",TRUE
+"238698_at",0.959869386255065,0.818544309723683,-0.23216046015728,-5.91346556272862,-0.183800690351709,"CASK","calcium/calmodulin dependent serine protein kinase",TRUE
+"211208_s_at",0.965562220217804,0.838822270889468,-0.205805256994122,-5.9190745615898,-0.0734022540714996,"CASK","calcium/calmodulin dependent serine protein kinase",TRUE
+"1552689_at",0.627092759817312,0.0985495634117198,-1.7244636694686,-4.58659095470663,-1.37830079228875,"CASKIN1","CASK interacting protein 1",TRUE
+"1569737_a_at",0.82153774281298,0.383900112975577,0.888340895595149,-5.56245796930997,0.366270605467814,"CASKIN1","CASK interacting protein 1",TRUE
+"239189_at",0.881970070870254,0.53919320882379,-0.623700015700207,-5.75197070488302,-0.488383947954738,"CASKIN1","CASK interacting protein 1",TRUE
+"61297_at",0.452452439518741,0.0217557835115641,-2.46840307962551,-3.34112462480377,-1.22571589446718,"CASKIN2","CASK interacting protein 2",TRUE
+"221846_s_at",0.547793752989355,0.0482467772429879,-2.0906062279871,-4.00930719394105,-1.00449554878276,"CASKIN2","CASK interacting protein 2",TRUE
+"211366_x_at",0.432192077156593,0.0193833052359995,2.52123265305509,-3.24277033604716,1.72784187748342,"CASP1","caspase 1",TRUE
+"211368_s_at",0.448873991611994,0.0213854150608844,2.47628575712876,-3.32651881879285,3.82928569324083,"CASP1","caspase 1",TRUE
+"209970_x_at",0.48580305784244,0.0284010221729508,2.34475456574855,-3.56689277920074,2.05859297570352,"CASP1","caspase 1",TRUE
+"211367_s_at",0.540483367247649,0.0449065055295306,2.12575754174007,-3.94998906562641,3.0299684581536,"CASP1","caspase 1",TRUE
+"206011_at",0.593339168375633,0.0705278693236989,1.89998253894727,-4.3195020951457,1.99254083069788,"CASP1","caspase 1",TRUE
+"210955_at",0.579111490485788,0.0621613938792952,1.96429685522509,-4.21708349114126,0.885713951122313,"CASP10","caspase 10",TRUE
+"205467_at",0.718706241731185,0.194505530955807,1.3378820174262,-5.10356384727104,1.11328165130923,"CASP10","caspase 10",TRUE
+"211888_x_at",0.789795896476304,0.318459712386984,1.02059875134844,-5.44469612051038,0.676555098279801,"CASP10","caspase 10",TRUE
+"210708_x_at",0.848804739090129,0.449280459977473,0.770261114422635,-5.65476710659626,0.524346009848565,"CASP10","caspase 10",TRUE
+"1564736_a_at",0.861610633839132,0.482234055895954,-0.714738507134429,-5.69388349880247,-0.529427631463459,"CASP12","caspase 12 (gene/pseudogene)",TRUE
+"231722_at",0.614024511254138,0.084961434148344,1.80328049990995,-4.46896877743911,1.75213289231218,"CASP14","caspase 14",TRUE
+"234231_at",0.823741997583852,0.390864003713689,0.875181436885821,-5.57335205447202,0.292524337448071,"CASP16P","caspase 16, pseudogene",TRUE
+"226032_at",0.785604733959291,0.311109532687454,-1.03658736298923,-5.42945545992435,-0.327336305354548,"CASP2","caspase 2",TRUE
+"209812_x_at",0.947445977129843,0.760738231318358,-0.308294233111686,-5.89349613583607,-0.279367148521206,"CASP2","caspase 2",TRUE
+"226036_x_at",0.947778780715578,0.762158798385297,-0.306402704468332,-5.89405988486064,-0.0794436225633426,"CASP2","caspase 2",TRUE
+"208050_s_at",0.982243328340126,0.914758664128586,0.108266632378489,-5.93397590273918,0.0517828222511145,"CASP2","caspase 2",TRUE
+"211140_s_at",0.992376456171815,0.964407837897421,0.045130166141546,-5.93869151242519,0.0494109672199645,"CASP2","caspase 2",TRUE
+"209811_at",0.995786113988252,0.979697013706641,0.0257376292845091,-5.93936084283211,0.0153708836900268,"CASP2","caspase 2",TRUE
+"34449_at",0.99886461451188,0.994995062150632,-0.00634395719400535,-5.93966387852625,-0.00446506616848907,"CASP2","caspase 2",TRUE
+"202763_at",0.97304633500821,0.869322077558832,-0.166437623308237,-5.92620010987249,-0.0826015751696936,"CASP3","caspase 3",TRUE
+"209310_s_at",0.314126572995991,0.00668658302247859,2.99184293378647,-2.32443281931008,2.69898703219579,"CASP4","caspase 4",TRUE
+"213596_at",0.415590231477955,0.0168690797419895,2.58426052148493,-3.12403469973783,1.35224448370526,"CASP4","caspase 4",TRUE
+"207500_at",0.72806517869755,0.208252607766822,1.29618053518238,-5.15291728326715,1.23777556815768,"CASP5","caspase 5",TRUE
+"211464_x_at",0.891355369164194,0.560732699001549,-0.590649046092322,-5.77117729173551,-0.214625613808938,"CASP6","caspase 6",TRUE
+"209790_s_at",0.985709215004606,0.930887101128406,-0.0877201478362264,-5.93593631036823,-0.035194122950081,"CASP6","caspase 6",TRUE
+"207181_s_at",0.875017160746837,0.521873517966047,-0.650791397165456,-5.73547686885804,-0.284219839853955,"CASP7","caspase 7",TRUE
+"1553306_at",0.686108994812404,0.154625767571493,1.47371134133293,-4.93384785430366,0.975379701425756,"CASP8","caspase 8",TRUE
+"207686_s_at",0.766390367856479,0.266994113178682,1.13869214518369,-5.32714119788782,0.438216912744654,"CASP8","caspase 8",TRUE
+"213373_s_at",0.81304218438764,0.362307679452924,0.93016968123942,-5.52683268073852,0.414470558512885,"CASP8","caspase 8",TRUE
+"1570001_at",0.676294804179428,0.142886853423338,1.51906872488092,-4.87421075765536,0.858570281794118,"CASP8AP2","caspase 8 associated protein 2",TRUE
+"222201_s_at",0.958931830316768,0.814029629913211,0.238050454743681,-5.91212020743809,0.0793097958358704,"CASP8AP2","caspase 8 associated protein 2",TRUE
+"203984_s_at",0.722937902375896,0.199403204292543,1.32276887923108,-5.1216024590561,0.457458591171584,"CASP9","caspase 9",TRUE
+"240437_at",0.919406408954167,0.657534657732052,0.449363059573986,-5.84180791814372,0.184873169998555,"CASP9","caspase 9",TRUE
+"210775_x_at",0.971242929121865,0.863351921786185,0.174120454435989,-5.92492751299276,0.0455922684213039,"CASP9","caspase 9",TRUE
+"219645_at",0.900902560132753,0.596993153290714,0.536450046841756,-5.80048083863514,0.292641796577476,"CASQ1","calsequestrin 1",TRUE
+"207317_s_at",0.913572663544659,0.637304060502926,-0.478040592754083,-5.82898723599236,-0.331069681578271,"CASQ2","calsequestrin 2",TRUE
+"240886_at",0.580630437263151,0.0631577457243225,1.95625094103539,-4.23002432944767,1.28365851794211,"CASR","calcium sensing receptor",TRUE
+"210577_at",0.677013732819214,0.144329168505014,-1.5133353165487,-4.88182912618167,-0.611539476830497,"CASR","calcium sensing receptor",TRUE
+"211384_s_at",0.860819742788118,0.480778002051367,-0.717143632949393,-5.69224662265991,-0.274215676331746,"CASR","calcium sensing receptor",TRUE
+"242745_at",0.881466832418197,0.538143238322774,-0.625328859263702,-5.75099809246956,-0.524224768249614,"CASR","calcium sensing receptor",TRUE
+"242744_s_at",0.959918062812665,0.818673603455959,0.231991904083021,-5.9135035697732,0.205968525065225,"CASR","calcium sensing receptor",TRUE
+"1554786_at",0.833430578034454,0.41095886897774,0.838038166188578,-5.60328475617267,0.595129165178491,"CASS4","Cas scaffolding protein family member 4",TRUE
+"220888_s_at",0.940044918888428,0.73103751756061,0.348117693288944,-5.88083003914289,0.278354068065054,"CASS4","Cas scaffolding protein family member 4",TRUE
+"212580_at",0.163850812837738,0.00130736490014292,3.67775596587328,-0.892850739667121,1.6563131883204,"CAST","calpastatin",TRUE
+"208908_s_at",0.255716413540338,0.00367331720749962,3.24717033621295,-1.8011168113612,1.638697796833,"CAST","calpastatin",TRUE
+"207467_x_at",0.358427723880268,0.0100166476542188,2.81616135735654,-2.675267698401,1.14190633254708,"CAST","calpastatin",TRUE
+"212586_at",0.42796179417767,0.0185964630249852,2.54009256322555,-3.20739706377365,1.64799550766962,"CAST","calpastatin",TRUE
+"1564010_at",0.470295441559609,0.0252335076172885,2.39991716336806,-3.4669627046034,1.12041357554575,"CAST","calpastatin",TRUE
+"235605_at",0.735001929272204,0.2200769691621,-1.261986431648,-5.19239458229694,-0.781165779452338,"CASZ1","castor zinc finger 1",TRUE
+"233863_at",0.808257777979515,0.350762907735116,-0.953219940810774,-5.50655695901656,-0.900491040633533,"CASZ1","castor zinc finger 1",TRUE
+"220015_at",0.873968636108443,0.519809530454695,-0.654052396918139,-5.73344608392747,-0.219898300261523,"CASZ1","castor zinc finger 1",TRUE
+"243386_at",0.932091525948902,0.699832336566483,-0.390587421254518,-5.86564978247767,-0.475683469932509,"CASZ1","castor zinc finger 1",TRUE
+"230420_at",0.975159323713639,0.878873228502977,-0.154167597968534,-5.92811376163537,-0.143839240102555,"CASZ1","castor zinc finger 1",TRUE
+"211922_s_at",0.560923390313819,0.0545571864219407,2.02977277907906,-4.11044651319964,1.13330822655142,"CAT","catalase",TRUE
+"201432_at",0.636860247875294,0.107954427304006,1.67519054269409,-4.65813191279462,0.875680670941954,"CAT","catalase",TRUE
+"215573_at",0.728385463227073,0.209711458602231,1.29188199143433,-5.15792934139668,0.988641241404878,"CAT","catalase",TRUE
+"1560625_s_at",0.898336157829132,0.587505140911032,-0.550469208037715,-5.79316339176167,-0.293619425103786,"CATIP-AS1","CATIP antisense RNA 1",TRUE
+"211601_at",0.952952008650351,0.784505781929304,-0.276791740908119,-5.90243652680939,-0.178492887059618,"CATR1","CATR tumorigenicity conversion 1",TRUE
+"1552335_at",0.759462911207093,0.257029752336096,1.16343499237209,-5.30106902376342,0.723765095128362,"CATSPER1","cation channel sperm associated 1",TRUE
+"230981_at",0.822850703882235,0.388602250113273,-0.879438537507136,-5.5698443078957,-0.284435511711707,"CATSPER3","cation channel sperm associated 3",TRUE
+"220293_at",0.684622294983819,0.153252716384215,-1.47886863242727,-4.92714021744418,-0.815365347007407,"CATSPERB","cation channel sperm associated auxiliary subunit beta",TRUE
+"1570470_at",0.818852235468236,0.372618459976833,0.909995575857074,-5.54420366650939,0.316397174411203,"CATSPERB","cation channel sperm associated auxiliary subunit beta",TRUE
+"237020_at",0.965883239653478,0.840231994537913,-0.203978793592823,-5.9194383704562,-0.142444405808386,"CATSPERD","cation channel sperm associated auxiliary subunit delta",TRUE
+"234353_at",0.654547695781813,0.123427283831925,-1.60150612487188,-4.76216074994888,-0.879529957441696,"CATSPERG","cation channel sperm associated auxiliary subunit gamma",TRUE
+"231261_at",0.848937021892,0.44950940649433,-0.76986710842732,-5.6550544395829,-0.446344533489162,"CATSPERG","cation channel sperm associated auxiliary subunit gamma",TRUE
+"221316_at",0.988776423002819,0.946014011168027,0.068484807644261,-5.93739933058478,0.0510235041607743,"CATSPERG","cation channel sperm associated auxiliary subunit gamma",TRUE
+"234705_at",0.52794071368681,0.0404971806712845,2.17595746735466,-3.86419598908412,0.901998776981302,"CATX-1","uncharacterized LOC100506513",TRUE
+"234595_at",0.929972194057784,0.690777703071431,0.40304521994878,-5.86087052821148,0.25956093064271,"CATX-1","uncharacterized LOC100506513",TRUE
+"203065_s_at",0.362885168249175,0.0104930441721207,2.79575173637422,-2.71545777308365,5.63731217358638,"CAV1","caveolin 1",TRUE
+"212097_at",0.384220082340749,0.0124875918851305,2.71887857552993,-2.86567956416999,5.55988035658049,"CAV1","caveolin 1",TRUE
+"213426_s_at",0.177045583630671,0.00158992924668788,3.5968964003875,-1.06524059074944,2.62728591293774,"CAV2","caveolin 2",TRUE
+"203323_at",0.30050033261608,0.00567292006993108,3.06245894505951,-2.18115282849792,4.45413811125407,"CAV2","caveolin 2",TRUE
+"203324_s_at",0.497725944448536,0.030744529955785,2.30747753070403,-3.63367258835847,4.98299312387894,"CAV2","caveolin 2",TRUE
+"208204_s_at",0.769847953580141,0.277749057058517,1.11273635698626,-5.35395977008718,0.680782235352775,"CAV3","caveolin 3",TRUE
+"1552355_s_at",0.956398858120188,0.802044355274165,0.253729290301966,-5.90837561619616,0.111710431048033,"CBARP","CACN beta subunit associated regulatory protein",TRUE
+"231019_x_at",0.956398858120188,0.802092764382494,0.253665834501006,-5.90839124974011,0.132430714364972,"CBARP","CACN beta subunit associated regulatory protein",TRUE
+"215325_x_at",0.996118448346386,0.980553273504355,0.0246519335143402,-5.93938748813727,0.021340496307996,"CBARP","CACN beta subunit associated regulatory protein",TRUE
+"1552354_at",0.99783553534859,0.989479329461054,-0.0133356867164159,-5.93959686155009,-0.00551334984793428,"CBARP","CACN beta subunit associated regulatory protein",TRUE
+"1554637_a_at",0.536559328842429,0.0434731337129651,2.1415685072186,-3.92310330297697,0.700799784285394,"CBFA2T2","CBFA2/RUNX1 translocation partner 2",TRUE
+"238549_at",0.603702127972549,0.0783693235546111,1.84551508323467,-4.4043728862847,0.957885405662802,"CBFA2T2","CBFA2/RUNX1 translocation partner 2",TRUE
+"209144_s_at",0.904180278332952,0.606507758717166,0.522499988459334,-5.80757991853973,0.267277808710944,"CBFA2T2","CBFA2/RUNX1 translocation partner 2",TRUE
+"209145_s_at",0.908709061737317,0.620389682891509,0.502332446680897,-5.81752075943522,0.186671254359319,"CBFA2T2","CBFA2/RUNX1 translocation partner 2",TRUE
+"207625_s_at",0.942684843065067,0.742904369225909,0.332141069138291,-5.88609417844459,0.089344209956959,"CBFA2T2","CBFA2/RUNX1 translocation partner 2",TRUE
+"208056_s_at",0.552420073963858,0.0501944749919047,-2.07110597687926,-4.0419393852771,-2.09974125986113,"CBFA2T3","CBFA2/RUNX1 translocation partner 3",TRUE
+"202370_s_at",0.624520459874487,0.0961388759405106,1.73773655050766,-4.56705484667517,0.512376692322336,"CBFB","core-binding factor beta subunit",TRUE
+"206788_s_at",0.734577729521114,0.219012753967623,1.26500523499218,-5.18894562629637,0.425030411017627,"CBFB","core-binding factor beta subunit",TRUE
+"225234_at",0.645072069975909,0.115552404899331,1.63797149577157,-4.71112725389697,0.474471837592107,"CBL","Cbl proto-oncogene",TRUE
+"229010_at",0.704481017254098,0.176484252278544,1.39620908627207,-5.03234341028923,0.595481407481048,"CBL","Cbl proto-oncogene",TRUE
+"225231_at",0.726320209350818,0.205229463452415,1.30516315017246,-5.14239806383383,0.54398421826064,"CBL","Cbl proto-oncogene",TRUE
+"243475_at",0.76858139690485,0.271706615949593,1.12722664840673,-5.33905520847895,0.693084345700933,"CBL","Cbl proto-oncogene",TRUE
+"206607_at",0.922853788070356,0.66970406491573,0.432296621920419,-5.84906858398912,0.146462123267119,"CBL","Cbl proto-oncogene",TRUE
+"209682_at",0.683019114815084,0.151800115503487,1.4843657614158,-4.9199697710508,0.696737519634425,"CBLB","Cbl proto-oncogene B",TRUE
+"208348_s_at",0.744307803443383,0.235220537307014,1.22019186540177,-5.2394159956134,1.10121205544649,"CBLB","Cbl proto-oncogene B",TRUE
+"227900_at",0.888232641270866,0.553951171285768,0.600981754621799,-5.76528118913956,0.466300438183829,"CBLB","Cbl proto-oncogene B",TRUE
+"220638_s_at",0.636860247875294,0.107881409086843,1.67555881503176,-4.65760301361277,2.54085135583436,"CBLC","Cbl proto-oncogene C",TRUE
+"223668_at",0.936318756756998,0.715704076105254,0.368899823897086,-5.87361697598168,0.251812961762456,"CBLC","Cbl proto-oncogene C",TRUE
+"227187_at",0.684160057382581,0.153074165193619,-1.47954204038812,-4.92626297848442,-0.51427646283325,"CBLL1","Cbl proto-oncogene like 1",TRUE
+"220018_at",0.901170466558277,0.597714600809682,-0.535388532275954,-5.80102743267195,-0.19118830090347,"CBLL1","Cbl proto-oncogene like 1",TRUE
+"205747_at",0.496742810480539,0.030358348952945,-2.31343670735075,-3.62303847536432,-1.99564139403165,"CBLN1","cerebellin 1 precursor",TRUE
+"242301_at",0.937462538530338,0.722785493088718,-0.359282035759115,-5.87700645339365,-0.289491689722901,"CBLN2","cerebellin 2 precursor",TRUE
+"235221_at",0.69805586360447,0.169076508830121,1.42156422140936,-5.00059973068317,0.473038023775838,"CBLN3","cerebellin 3 precursor",TRUE
+"242524_at",0.579111490485788,0.0621395315981762,1.96447467543585,-4.21679708147513,1.88501048109638,"CBLN4","cerebellin 4 precursor",TRUE
+"234024_at",0.976371465776674,0.886862073757644,-0.14392327019011,-5.92959953324727,-0.0757727121273657,"CBLN4","cerebellin 4 precursor",TRUE
+"209213_at",0.708894565317004,0.181505533056657,1.3795006817977,-5.05300354602907,2.60829409119969,"CBR1","carbonyl reductase 1",TRUE
+"205379_at",0.698391916012681,0.169467716830922,1.42020319739037,-5.00231561157763,0.898640540269847,"CBR3","carbonyl reductase 3",TRUE
+"1559917_a_at",0.924812035112346,0.674762646841089,-0.425240946905422,-5.8519896633284,-0.221841276565,"CBR3-AS1","CBR3 antisense RNA 1",TRUE
+"1559501_at",0.960693014177181,0.821398855212749,0.228440671446134,-5.91429793858187,0.160563810871662,"CBR3-AS1","CBR3 antisense RNA 1",TRUE
+"244052_at",0.830635993561085,0.403519195641769,0.851650901675515,-5.59245503442417,0.376933989301069,"CBR4","carbonyl reductase 4",TRUE
+"213626_at",0.980025041090473,0.906216194383175,-0.119167928035366,-5.9327690658004,-0.0702122606871889,"CBR4","carbonyl reductase 4",TRUE
+"1553693_s_at",0.989475734766121,0.948021162586343,0.0659346688293132,-5.9375662537827,0.0468403068489813,"CBR4","carbonyl reductase 4",TRUE
+"240517_at",0.540483367247649,0.0448667281267307,2.12619013403089,-3.94925514078297,1.62288039786644,"CBS","cystathionine-beta-synthase",TRUE
+"212816_s_at",0.891653456393983,0.561501125726706,0.589482331447358,-5.77183683805779,0.853780073102582,"CBS","cystathionine-beta-synthase",TRUE
+"1553972_a_at",0.928295253101366,0.685280630772617,0.410640010734469,-5.85788442691964,0.454825170977362,"CBS","cystathionine-beta-synthase",TRUE
+"229804_x_at",0.605036207476073,0.0789230586505597,-1.84185112488861,-4.41001918166839,-0.629868527408698,"CBWD7///CBWD6///CBWD3///CBWD5///CBWD2///CBWD1","COBW domain containing 7///COBW domain containing 6///COBW domain containing 3///COBW domain containing 5///COBW domain containing 2///COBW domain containing 1",TRUE
+"220175_s_at",0.63616483035166,0.107660505440335,-1.67667424296473,-4.65600053945377,-0.874953112113408,"CBWD7///CBWD6///CBWD3///CBWD5///CBWD2///CBWD1","COBW domain containing 7///COBW domain containing 6///COBW domain containing 3///COBW domain containing 5///COBW domain containing 2///COBW domain containing 1",TRUE
+"226193_x_at",0.808390506945581,0.351404063622782,-0.951926494394607,-5.50770676379342,-0.407937165385485,"CBWD7///CBWD6///CBWD3///CBWD5///CBWD2///CBWD1","COBW domain containing 7///COBW domain containing 6///COBW domain containing 3///COBW domain containing 5///COBW domain containing 2///COBW domain containing 1",TRUE
+"201518_at",0.653593944884398,0.122972490370842,-1.60355834943049,-4.75931227271683,-0.506172178173941,"CBX1","chromobox 1",TRUE
+"226473_at",0.411110107932987,0.0162103927886702,-2.6022274264763,-3.08991927374172,-1.59558522625946,"CBX2","chromobox 2",TRUE
+"224138_at",0.606312240108248,0.07997665982004,1.83494091083646,-4.42064625906347,0.518264491660005,"CBX2","chromobox 2",TRUE
+"215989_at",0.622026794278124,0.092254621853881,-1.75973410246535,-4.53443299050145,-1.92438475233218,"CBX2","chromobox 2",TRUE
+"240084_at",0.686081665045981,0.154355768150347,-1.4747225349551,-4.93253417515087,-0.524575547387725,"CBX2","chromobox 2",TRUE
+"230998_at",0.871451481476429,0.512874139280635,0.665062715521132,-5.72651750425873,0.4673177904028,"CBX3","chromobox 3",TRUE
+"1555920_at",0.886940322815928,0.550641103203729,-0.606049152644991,-5.76235351629483,-0.270812838667941,"CBX3","chromobox 3",TRUE
+"200037_s_at",0.955234687900581,0.795338796475503,0.262529516767838,-5.90616988092729,0.0667577157464674,"CBX3","chromobox 3",TRUE
+"201091_s_at",0.982472489567768,0.915303176975097,0.107572233316549,-5.93404886197813,0.0270905349471349,"CBX3","chromobox 3",TRUE
+"1557488_at",0.614788745141381,0.0855588031418522,-1.79959496705433,-4.47455443257399,-0.932508700939763,"CBX3P2","chromobox 3 pseudogene 2",TRUE
+"206724_at",0.439734782930756,0.0202856582085122,-2.5004641310721,-3.28156565540771,-1.45273978110691,"CBX4","chromobox 4",TRUE
+"227558_at",0.56889440085039,0.0587467359341802,-1.99276541107489,-4.1710067539292,-1.03456695629378,"CBX4","chromobox 4",TRUE
+"242069_at",0.623503825356688,0.0946179103574295,-1.74625787949445,-4.55445390625957,-1.21973281805467,"CBX5","chromobox 5",TRUE
+"212126_at",0.746259710622309,0.237979794663281,-1.21279818118343,-5.24759199688218,-0.643625140468599,"CBX5","chromobox 5",TRUE
+"226085_at",0.883410339479976,0.541427181113032,0.620240042139396,-5.75402861050398,0.501449781065428,"CBX5","chromobox 5",TRUE
+"209715_at",0.919378883093968,0.657415626965728,-0.4495306518588,-5.84173525114851,-0.239092255573667,"CBX5","chromobox 5",TRUE
+"231862_at",0.928777626237599,0.686525047291932,0.408918580250531,-5.85856606244757,0.31839739510486,"CBX5","chromobox 5",TRUE
+"234990_at",0.940668681806864,0.73455974000884,0.343366184919707,-5.88242115861722,0.194083436132162,"CBX5","chromobox 5",TRUE
+"202048_s_at",0.112518135066489,0.000590630174011566,-4.00398297401224,-0.192098382807683,-1.40910025237161,"CBX6","chromobox 6",TRUE
+"202047_s_at",0.429170076412192,0.0187602284958758,-2.53610663154233,-3.21488425292516,-0.895855183223713,"CBX6","chromobox 6",TRUE
+"212914_at",0.948429371744093,0.765747919557966,0.301628740287978,-5.89546742053237,0.196124182265057,"CBX7","chromobox 7",TRUE
+"219755_at",0.683019114815084,0.151899477699119,-1.48398838139981,-4.92046271050546,-0.828902731609776,"CBX8","chromobox 8",TRUE
+"1560220_a_at",0.894729774938685,0.571614950158978,0.574202219083146,-5.78035821491531,0.378129988621792,"CBY1","chibby family member 1, beta catenin antagonist",TRUE
+"203450_at",0.901781358899845,0.598863241083833,-0.533699743005343,-5.80189485182957,-0.20419386702268,"CBY1","chibby family member 1, beta catenin antagonist",TRUE
+"241712_at",0.769847953580141,0.27798845305286,1.1121670178521,-5.35454189829708,0.351547948863474,"CBY3","chibby family member 3",TRUE
+"207083_s_at",0.768852835478002,0.273744775667125,1.12231290837358,-5.34412855239373,0.946517308814193,"CC2D1A","coiled-coil and C2 domain containing 1A",TRUE
+"222137_at",0.78515014907967,0.310475004789332,1.0379800437094,-5.42811781703222,0.839201529431448,"CC2D1A","coiled-coil and C2 domain containing 1A",TRUE
+"221888_at",0.924375464109345,0.673665564570662,0.42676927477793,-5.85136093608415,0.156914962772859,"CC2D1A","coiled-coil and C2 domain containing 1A",TRUE
+"58994_at",0.985673230154868,0.930738862960768,0.0879088028385067,-5.93592017836521,0.0345252878363382,"CC2D1A","coiled-coil and C2 domain containing 1A",TRUE
+"242487_at",0.871451481476429,0.512870965205434,-0.665067773401528,-5.72651429595765,-0.26362834513629,"CC2D1B","coiled-coil and C2 domain containing 1B",TRUE
+"225323_at",0.947062793209778,0.759850087786618,0.309477406481742,-5.89314175645516,0.119875890205739,"CC2D1B","coiled-coil and C2 domain containing 1B",TRUE
+"234936_s_at",0.627092759817312,0.0985902476167625,1.72424205762576,-4.58691619471077,0.703597241813418,"CC2D2A","coiled-coil and C2 domain containing 2A",TRUE
+"234933_at",0.774230543658252,0.287615349401517,-1.08956110761127,-5.37744161864543,-0.862006783817655,"CC2D2A","coiled-coil and C2 domain containing 2A",TRUE
+"1559409_a_at",0.821745015752602,0.384495878729406,0.887209032686519,-5.56340090857346,0.506182708749463,"CC2D2A","coiled-coil and C2 domain containing 2A",TRUE
+"236473_at",0.954618087644887,0.793117095263419,0.265449871456504,-5.90542139932587,0.260094038108617,"CC2D2A","coiled-coil and C2 domain containing 2A",TRUE
+"243534_at",0.897375964261386,0.583820654637278,0.555943336242615,-5.79025634350451,0.328890201423824,"CC2D2B","coiled-coil and C2 domain containing 2B",TRUE
+"239014_at",0.823718501969623,0.390777385012047,-0.875344176494243,-5.57321825149233,-0.769178461709113,"CCAR1","cell division cycle and apoptosis regulator 1",TRUE
+"224737_x_at",0.841247691968787,0.431429618798592,-0.801367292964911,-5.6316455308845,-0.231033769322147,"CCAR1","cell division cycle and apoptosis regulator 1",TRUE
+"224736_at",0.953983577550391,0.788370482877466,-0.271697087027928,-5.90379263942813,-0.0811312429586266,"CCAR1","cell division cycle and apoptosis regulator 1",TRUE
+"225193_at",0.723973974120865,0.200921391931788,-1.31814302227413,-5.12708923675264,-0.530574920462493,"CCAR2","cell cycle and apoptosis regulator 2",TRUE
+"225187_at",0.90343137006939,0.603657797254011,-0.526667399763849,-5.80547822550144,-0.267154017328098,"CCAR2","cell cycle and apoptosis regulator 2",TRUE
+"221070_s_at",0.998347572104896,0.993037275996828,0.00882558665149646,-5.93964554299588,0.00438626966106348,"CCAR2","cell cycle and apoptosis regulator 2",TRUE
+"243805_at",0.8717332853209,0.5133457015869,0.664311475796582,-5.72699376899882,0.580800707528756,"CCBE1","collagen and calcium binding EGF domains 1",TRUE
+"242324_x_at",0.892780783477555,0.566071944376678,0.582559341643379,-5.77572446824198,0.38015031795782,"CCBE1","collagen and calcium binding EGF domains 1",TRUE
+"229641_at",0.993225426079816,0.967818693158375,0.0408026259726355,-5.93887262414153,0.0512834292888709,"CCBE1","collagen and calcium binding EGF domains 1",TRUE
+"232051_at",0.883114005048829,0.540844577294835,0.621141641572663,-5.75349342421635,0.515184091303676,"CCDC102A","coiled-coil domain containing 102A",TRUE
+"234180_at",0.861659105448003,0.483517492793677,-0.712622008997833,-5.69531961157465,-0.611774577797421,"CCDC102B","coiled-coil domain containing 102B",TRUE
+"220301_at",0.89732810490777,0.583642984709656,0.556207737808675,-5.79011522551531,0.631713307621658,"CCDC102B","coiled-coil domain containing 102B",TRUE
+"1553893_at",0.789614764278615,0.316972379449237,1.02381303043639,-5.44164938279453,0.571461803715432,"CCDC105","coiled-coil domain containing 105",TRUE
+"207006_s_at",0.738432901892148,0.225277746750088,-1.24739242725038,-5.20896844953563,-1.6452164759908,"CCDC106","coiled-coil domain containing 106",TRUE
+"229063_s_at",0.947326616179611,0.760478249083539,-0.308640531527894,-5.89339255313469,-0.097152207204557,"CCDC107","coiled-coil domain containing 107",TRUE
+"230900_at",0.69826535129815,0.169162844566698,-1.42126363998194,-5.00097879810816,-1.79544157164066,"CCDC110","coiled-coil domain containing 110",TRUE
+"235208_at",0.973372948129726,0.871185444621347,-0.164041827321472,-5.92658524071735,-0.0540764867817778,"CCDC112","coiled-coil domain containing 112",TRUE
+"222890_at",0.863110153327623,0.487130372407568,0.706681483076846,-5.6993287817483,0.511869460135688,"CCDC113","coiled-coil domain containing 113",TRUE
+"233157_x_at",0.9286288141895,0.686268436721487,0.409273452624974,-5.85842577403382,0.312519640992026,"CCDC114","coiled-coil domain containing 114",TRUE
+"224946_s_at",0.593339168375633,0.0701533074306279,-1.90271457355172,-4.31519944863808,-0.669718580482078,"CCDC115","coiled-coil domain containing 115",TRUE
+"1555792_a_at",0.774230543658252,0.286694700027691,1.09169909170663,-5.37529376075656,0.432764260377656,"CCDC116","coiled-coil domain containing 116",TRUE
+"225644_at",0.637236149092845,0.108112058923568,-1.6743962347391,-4.65927236857051,-0.86733270639656,"CCDC117","coiled-coil domain containing 117",TRUE
+"235330_at",0.771011793494937,0.279692062935564,-1.10812570223501,-5.35866639832828,-0.518720914023342,"CCDC117","coiled-coil domain containing 117",TRUE
+"226011_at",0.958933497686198,0.81425082515969,-0.237761677475541,-5.91218694962305,-0.0818772876294158,"CCDC12","coiled-coil domain containing 12",TRUE
+"239403_at",0.761261833217751,0.260303747400544,1.15522824086581,-5.30977126735347,0.394544600894072,"CCDC120","coiled-coil domain containing 120",TRUE
+"232996_at",0.988391891288248,0.944519459213972,-0.070383976682729,-5.93727090469496,-0.0494361918971054,"CCDC120","coiled-coil domain containing 120",TRUE
+"220321_s_at",0.705378331100654,0.17708318194216,-1.394196432248,-5.0348429847931,-0.514534088410531,"CCDC121","coiled-coil domain containing 121",TRUE
+"1553894_at",0.606513405756992,0.0800586602532823,1.83440642004265,-4.42146705106531,1.48160379416519,"CCDC122","coiled-coil domain containing 122",TRUE
+"225454_at",0.78720346978568,0.31298086924922,-1.03249172072985,-5.43337986606315,-0.39225045648611,"CCDC124","coiled-coil domain containing 124",TRUE
+"225453_x_at",0.923573053923573,0.671907426355864,0.429220667650919,-5.85034784800573,0.161991863591287,"CCDC124","coiled-coil domain containing 124",TRUE
+"229082_at",0.54797846391898,0.0482882531168111,-2.09018367512346,-4.01001639682507,-1.15231646204203,"CCDC125","coiled-coil domain containing 125",TRUE
+"1553542_at",0.720018659171833,0.195847766853639,-1.33371081374095,-5.10855969463454,-0.679203589034809,"CCDC125","coiled-coil domain containing 125",TRUE
+"228061_at",0.967751868840214,0.848347129796847,0.19347826563636,-5.921467267603,0.0789764564806523,"CCDC126","coiled-coil domain containing 126",TRUE
+"228087_at",0.997332669167948,0.986497450046124,-0.0171157708753156,-5.939540796801,-0.00775555495969549,"CCDC126","coiled-coil domain containing 126",TRUE
+"236046_at",0.885199632879984,0.546322385219976,0.612684864774387,-5.75848388815755,0.310672808735169,"CCDC127","coiled-coil domain containing 127",TRUE
+"226515_at",0.8913721384714,0.560788934059927,0.590563635457803,-5.77122561732772,0.152168098992055,"CCDC127","coiled-coil domain containing 127",TRUE
+"231653_at",0.889389445320988,0.557186540012299,0.596044004994622,-5.768111119034,0.450814670877646,"CCDC129","coiled-coil domain containing 129",TRUE
+"234027_at",0.925389506721126,0.676796846839058,-0.422409854301288,-5.85314846855264,-0.17508649922363,"CCDC129","coiled-coil domain containing 129",TRUE
+"1554022_at",0.767727587789514,0.270179354238047,-1.13092638658264,-5.33522237386467,-0.765065859055814,"CCDC13","coiled-coil domain containing 13",TRUE
+"1554023_s_at",0.813065886130395,0.362916271786246,0.928968349913823,-5.52787690862547,0.34971162794502,"CCDC13","coiled-coil domain containing 13",TRUE
+"1553397_at",0.856795624765386,0.470982944715568,0.733434979325921,-5.68102148285845,0.199144120148362,"CCDC13","coiled-coil domain containing 13",TRUE
+"1553396_a_at",0.955515814503015,0.796201630910763,-0.261395978720225,-5.90645818878714,-0.192062157267658,"CCDC13","coiled-coil domain containing 13",TRUE
+"1557652_a_at",0.614679164596232,0.0854985833882825,-1.79996549019703,-4.47399325620197,-0.913607962886588,"CCDC13-AS1","CCDC13 antisense RNA 1",TRUE
+"208094_s_at",0.989524702314661,0.948577305589735,-0.0652281544790762,-5.9376113797969,-0.0263063594096611,"CCDC130","coiled-coil domain containing 130",TRUE
+"235434_at",0.840196220146749,0.429230859674319,0.8052532244362,-5.62869658232007,0.421170308503347,"CCDC134","coiled-coil domain containing 134",TRUE
+"220077_at",0.914910510855952,0.641538723279994,0.472004876392421,-5.83175008647662,0.418979898405768,"CCDC134","coiled-coil domain containing 134",TRUE
+"226972_s_at",0.580630437263151,0.0631124955851893,1.95661391428104,-4.22944131252536,0.627403644083541,"CCDC136","coiled-coil domain containing 136",TRUE
+"226971_at",0.694505490882266,0.163863966830048,-1.43994450548672,-4.97729542994466,-0.756212163870947,"CCDC136","coiled-coil domain containing 136",TRUE
+"232989_s_at",0.763502833200335,0.263340401069811,1.14768438658064,-5.31772285119405,0.781608118546656,"CCDC136","coiled-coil domain containing 136",TRUE
+"225933_at",0.852094603401457,0.457705856750518,-0.755840512998631,-5.6651929496336,-0.282176533287457,"CCDC137","coiled-coil domain containing 137",TRUE
+"230339_at",0.883640993945684,0.541901829483288,-0.619505890187659,-5.75446384725848,-0.260669545807493,"CCDC138","coiled-coil domain containing 138",TRUE
+"235644_at",0.974292018919448,0.87459080546075,0.159665963841301,-5.92727429591352,0.106874495911996,"CCDC138","coiled-coil domain containing 138",TRUE
+"1561054_a_at",0.622434989367596,0.0929662533611982,1.75564530708836,-4.5405194923677,1.02094581673363,"CCDC14","coiled-coil domain containing 14",TRUE
+"240884_at",0.646725013641643,0.117764869425079,1.62752128745867,-4.72584297670964,0.900901158482415,"CCDC14","coiled-coil domain containing 14",TRUE
+"225017_at",0.975288955815877,0.880605210457475,0.151945231412389,-5.9284447344514,0.0576890522068627,"CCDC14","coiled-coil domain containing 14",TRUE
+"1553485_at",0.619119851132342,0.0894340847598214,1.77621112913636,-4.50980026086489,1.31736268825612,"CCDC140","coiled-coil domain containing 140",TRUE
+"1553645_at",0.84932977991296,0.45030517966736,0.76849856603087,-5.65605138482608,0.712583682825327,"CCDC141","coiled-coil domain containing 141",TRUE
+"1563456_at",0.862779849418027,0.486438987437771,-0.707816325371123,-5.69856536432586,-0.626838287482621,"CCDC141","coiled-coil domain containing 141",TRUE
+"239922_at",0.884986112364738,0.545109258854718,0.614553820252903,-5.75738666795056,0.215067011324204,"CCDC142","coiled-coil domain containing 142",TRUE
+"1561477_at",0.698955864196462,0.170306173256978,1.41729464156555,-5.00597798537745,0.954475990473654,"CCDC144A","coiled-coil domain containing 144A",TRUE
+"216045_at",0.941400961503247,0.73798651145095,0.338751163384578,-5.88394587497986,0.228561496882465,"CCDC144A","coiled-coil domain containing 144A",TRUE
+"1561271_at",0.783844746433788,0.306621215145909,1.04648192085607,-5.41991687738741,0.843157332733835,"CCDC144CP","coiled-coil domain containing 144C, pseudogene",TRUE
+"1564360_a_at",0.280199223932988,0.00462830781169326,3.14928532981379,-2.00340268814307,4.39794083626473,"CCDC144NL-AS1","CCDC144NL antisense RNA 1",TRUE
+"1564359_a_at",0.348854934125219,0.00915315814357627,2.85562857674185,-2.59720001724341,4.59044297706449,"CCDC144NL-AS1","CCDC144NL antisense RNA 1",TRUE
+"1560099_at",0.417001048339868,0.0170232526729691,2.58015027811745,-3.13182273280473,4.30477318217993,"CCDC144NL-AS1","CCDC144NL antisense RNA 1",TRUE
+"229669_at",0.580137756009815,0.0626189759278687,1.96058766856054,-4.22305374455277,2.60955319081509,"CCDC144NL-AS1","CCDC144NL antisense RNA 1",TRUE
+"227091_at",0.709914655587487,0.182769643716038,1.37535223616899,-5.05810116784344,0.440885614086891,"CCDC146","coiled-coil domain containing 146",TRUE
+"231504_at",0.67317100184305,0.138684922995155,-1.53604715148172,-4.85151592319303,-1.65229222221322,"CCDC148","coiled-coil domain containing 148",TRUE
+"1564757_a_at",0.823933875444718,0.391218882672455,-0.874514933026302,-5.57389980665623,-0.341333767056047,"CCDC148","coiled-coil domain containing 148",TRUE
+"1555224_at",0.667692826980501,0.134088106817483,1.55511328595922,-4.82579233746138,1.05677186817169,"CCDC148-AS1","CCDC148 antisense RNA 1",TRUE
+"226141_at",0.743869497380606,0.234677731327262,-1.22165407409562,-5.23779398006414,-0.886801058985651,"CCDC149","coiled-coil domain containing 149",TRUE
+"1553839_at",0.791646964605038,0.322297347812873,1.01235344674536,-5.45247202509691,0.520486118597315,"CCDC149","coiled-coil domain containing 149",TRUE
+"1553840_a_at",0.825056354800234,0.392489358744647,0.872132042042869,-5.57585496568572,0.519047244499491,"CCDC149","coiled-coil domain containing 149",TRUE
+"226139_at",0.836756831475262,0.418641277636957,-0.824144440415226,-5.61416982192331,-0.364566107491815,"CCDC149","coiled-coil domain containing 149",TRUE
+"220466_at",0.7717895132349,0.281459306953683,1.10395228530434,-5.36291173012814,0.463207244990592,"CCDC15","coiled-coil domain containing 15",TRUE
+"241360_at",0.867099100798202,0.498890146758393,0.687518921393947,-5.71204311092473,0.446426754754084,"CCDC15","coiled-coil domain containing 15",TRUE
+"243565_at",0.851319596585235,0.455042672191808,0.760381299336772,-5.66193013339505,0.284122805317048,"CCDC150","coiled-coil domain containing 150",TRUE
+"232398_at",0.866425733191666,0.497448014460349,0.689854888537737,-5.71051105641443,0.416278626988968,"CCDC150","coiled-coil domain containing 150",TRUE
+"1553459_at",0.969859842767097,0.855759528953197,-0.183906481111779,-5.92322364279854,-0.14197372268903,"CCDC150","coiled-coil domain containing 150",TRUE
+"230807_at",0.930708572679794,0.693089482333982,0.399858467301126,-5.86210714438429,0.155910927677898,"CCDC151","coiled-coil domain containing 151",TRUE
+"242519_at",0.583068510086268,0.064529447728066,1.94535534180751,-4.24749069528652,1.63924263392853,"CCDC152","coiled-coil domain containing 152",TRUE
+"237475_x_at",0.943464796017993,0.746542186296574,0.327261187367789,-5.88765328091816,0.150609407957354,"CCDC152","coiled-coil domain containing 152",TRUE
+"240293_at",0.881466832418197,0.538155507150222,0.625309816513865,-5.75100947735774,0.661164244662285,"CCDC153","coiled-coil domain containing 153",TRUE
+"244409_at",0.96479405380661,0.837090059237024,-0.208050523444848,-5.9186229067806,-0.099188236286778,"CCDC154","coiled-coil domain containing 154",TRUE
+"240950_s_at",0.984132887597385,0.922250680132122,-0.0987169471378988,-5.934938147557,-0.0348784941844471,"CCDC155","coiled-coil domain containing 155",TRUE
+"232920_at",0.776696310319783,0.294067943412531,1.07471312663208,-5.39225452167586,0.395132031245003,"CCDC157","coiled-coil domain containing 157",TRUE
+"242949_x_at",0.822692659006798,0.387745169271992,-0.881055956370313,-5.56850745433638,-0.365524842697288,"CCDC157","coiled-coil domain containing 157",TRUE
+"1568796_at",0.877861946695164,0.529225121864074,0.639233310251821,-5.74259614295597,0.300655353837923,"CCDC157","coiled-coil domain containing 157",TRUE
+"243875_at",0.635368778245437,0.106489121650108,1.68262158655551,-4.64744268849103,1.33938916768218,"CCDC158","coiled-coil domain containing 158",TRUE
+"1554846_at",0.75959865506602,0.257281725565543,-1.16280064183006,-5.30174360067418,-0.908799180140554,"CCDC158","coiled-coil domain containing 158",TRUE
+"227043_at",0.800053470634826,0.3354744883183,0.984551052826838,-5.47826978966297,0.644186402578542,"CCDC159","coiled-coil domain containing 159",TRUE
+"1563022_at",0.896345073598643,0.580486952016954,-0.560911133410091,-5.78759402054385,-0.596897842313888,"CCDC160","coiled-coil domain containing 160",TRUE
+"236900_x_at",0.855405088766616,0.468394540745633,0.73777327923546,-5.67799191971854,0.229660494765042,"CCDC163","coiled-coil domain containing 163",TRUE
+"1559003_a_at",0.95715439915087,0.805896188345126,-0.248683519545543,-5.90960660517135,-0.0885263279691655,"CCDC163","coiled-coil domain containing 163",TRUE
+"225723_at",0.798737990058781,0.333278746188691,-0.989130727840422,-5.47406522395767,-0.447304191382397,"CCDC167","coiled-coil domain containing 167",TRUE
+"1561846_s_at",0.909304648717545,0.623455029395532,-0.497907739571244,-5.81965069226498,-0.420493451324438,"CCDC168","coiled-coil domain containing 168",TRUE
+"1566665_at",0.940044918888428,0.731617502829218,0.347334729053404,-5.88109371480082,0.238316174316174,"CCDC168","coiled-coil domain containing 168",TRUE
+"1566664_at",0.976371465776674,0.886745885832708,-0.144072145659433,-5.92957867104651,-0.103448416609304,"CCDC168","coiled-coil domain containing 168",TRUE
+"234085_at",0.554642754132296,0.0509959129489547,2.06327830771114,-4.05498255750127,1.55650504850933,"CCDC169","coiled-coil domain containing 169",TRUE
+"233503_at",0.620912785033482,0.0908451747862364,1.76791286529537,-4.52222700619294,0.706325856258041,"CCDC169","coiled-coil domain containing 169",TRUE
+"1570153_at",0.885744737126215,0.54759841983247,0.610721362641162,-5.75963314274647,0.76405862291996,"CCDC169","coiled-coil domain containing 169",TRUE
+"233298_at",0.949758921611699,0.772540073540687,0.292613801439697,-5.89806558632018,0.182288740308969,"CCDC169","coiled-coil domain containing 169",TRUE
+"233297_s_at",0.973433731874338,0.871688793802262,0.163394822906947,-5.92668829333643,0.173926709209968,"CCDC169-SOHLH2///CCDC169","CCDC169-SOHLH2 readthrough///coiled-coil domain containing 169",TRUE
+"220129_at",0.646392036827936,0.117418693009037,1.62914546326597,-4.72356060918877,1.49424349033484,"CCDC169-SOHLH2///SOHLH2","CCDC169-SOHLH2 readthrough///spermatogenesis and oogenesis specific basic helix-loop-helix 2",TRUE
+"236320_at",0.966593471043185,0.844397874052174,0.198585525390712,-5.92049378981249,0.115570790601621,"CCDC17","coiled-coil domain containing 17",TRUE
+"220581_at",0.709158363400091,0.181776385028361,-1.37860990049522,-5.05409921567744,-1.92031963333436,"CCDC170","coiled-coil domain containing 170",TRUE
+"1553433_at",0.308861881799719,0.00647946188247422,-3.00539369002878,-2.29703238818552,-2.38717919322895,"CCDC171","coiled-coil domain containing 171",TRUE
+"236945_at",0.627092759817312,0.0988118230787065,1.7230364766278,-4.58868497295819,1.91113834139126,"CCDC171","coiled-coil domain containing 171",TRUE
+"242821_at",0.812302873476553,0.360349486499439,0.93404425344078,-5.52345635070299,0.342465715379016,"CCDC171","coiled-coil domain containing 171",TRUE
+"1558082_at",0.862125670830879,0.484947668890537,0.710267360725318,-5.69691255163003,0.306705042885343,"CCDC171","coiled-coil domain containing 171",TRUE
+"1558160_at",0.94118897722809,0.736693803355602,0.340491237948937,-5.88337338306533,0.296688645507351,"CCDC171","coiled-coil domain containing 171",TRUE
+"1559672_a_at",0.955396260969248,0.795770383622123,0.261962480664005,-5.9063142577006,0.162532532613701,"CCDC171","coiled-coil domain containing 171",TRUE
+"239712_at",0.974821362145526,0.876569370758402,0.157124992801707,-5.92766588701219,0.139291716801071,"CCDC171","coiled-coil domain containing 171",TRUE
+"1555443_at",0.817857130700434,0.370543404179081,-0.914025512211469,-5.54076173509884,-0.496652858729995,"CCDC172","coiled-coil domain containing 172",TRUE
+"236909_at",0.745235425991344,0.236907854396992,-1.21566281162849,-5.24442936888721,-0.90846603229678,"CCDC173","coiled-coil domain containing 173",TRUE
+"1558094_s_at",0.67606695078322,0.142626488049258,-1.52010876538912,-4.87282632335694,-0.418454781018174,"CCDC174","coiled-coil domain containing 174",TRUE
+"225559_at",0.821424121108148,0.383388588702823,-0.889313629896579,-5.56164670806458,-0.251709210636935,"CCDC174","coiled-coil domain containing 174",TRUE
+"223787_s_at",0.934408715273411,0.709261931276851,-0.377680244451899,-5.87044544984614,-0.0939631608176068,"CCDC174","coiled-coil domain containing 174",TRUE
+"220887_at",0.713330901550199,0.187868078104808,-1.35884764701253,-5.0782554433237,-0.506523768335516,"CCDC177","coiled-coil domain containing 177",TRUE
+"1558820_a_at",0.804212866894346,0.34289507499955,0.969224634646506,-5.49221152343449,0.560868396902944,"CCDC178","coiled-coil domain containing 178",TRUE
+"236665_at",0.623503825356688,0.0946579049294086,1.74603231089063,-4.5547880543481,1.05407641285946,"CCDC18","coiled-coil domain containing 18",TRUE
+"228022_at",0.634499515855866,0.105551006579582,1.68742466772708,-4.6405146378598,0.502881394483256,"CCDC18","coiled-coil domain containing 18",TRUE
+"232362_at",0.773234064853267,0.284249758442857,1.09740103851195,-5.36954715271119,0.460202257766519,"CCDC18","coiled-coil domain containing 18",TRUE
+"230073_at",0.754682106570676,0.24827568864403,-1.18576653486152,-5.27711635132205,-0.817909775633246,"CCDC18-AS1","CCDC18 antisense RNA 1",TRUE
+"227074_at",0.984161165881616,0.92258602145121,0.0982897314886178,-5.93497912173895,0.0519119663148544,"CCDC18-AS1","CCDC18 antisense RNA 1",TRUE
+"229628_s_at",0.785461218411795,0.310996162997101,1.03683604309094,-5.42921672614923,0.932997314620849,"CCDC180///LOC100499484-C9ORF174","coiled-coil domain containing 180///LOC100499484-C9orf174 readthrough",TRUE
+"229627_at",0.805584262266138,0.344873557841854,0.965176679963287,-5.49586043820871,0.490851757581645,"CCDC180///LOC100499484-C9ORF174","coiled-coil domain containing 180///LOC100499484-C9orf174 readthrough",TRUE
+"206721_at",0.757361197594703,0.253224438366426,1.17307161437114,-5.29078168895661,0.558756087527609,"CCDC181","coiled-coil domain containing 181",TRUE
+"1562854_at",0.800342373547779,0.336126784150138,-0.983194532829661,-5.47951179137145,-0.725390353091186,"CCDC181","coiled-coil domain containing 181",TRUE
+"1555111_at",0.813631136157676,0.364397882521563,-0.926049345895124,-5.53040900848959,-0.657329394936949,"CCDC181","coiled-coil domain containing 181",TRUE
+"1555112_a_at",0.865148641923909,0.494277972158704,0.695003322087064,-5.70711691494467,0.300089810242177,"CCDC181","coiled-coil domain containing 181",TRUE
+"236942_at",0.933448396773721,0.705603264907076,0.382680331166885,-5.86860651662583,0.309971907992288,"CCDC182","coiled-coil domain containing 182",TRUE
+"229626_at",0.937113154905832,0.719498169834137,-0.36374243932349,-5.87544552076228,-0.210446104632897,"CCDC184","coiled-coil domain containing 184",TRUE
+"1552391_at",0.716472449896956,0.192296727705836,1.34479562238717,-5.09525459995704,0.622335477757654,"CCDC185","coiled-coil domain containing 185",TRUE
+"219844_at",0.402343327327244,0.0146072520300792,2.64899625132534,-3.00057578017655,0.77724861007459,"CCDC186","coiled-coil domain containing 186",TRUE
+"227701_at",0.683838837468118,0.1526692989456,1.48107136696317,-4.92426954991435,0.600787356367247,"CCDC186","coiled-coil domain containing 186",TRUE
+"229399_at",0.737488397392592,0.223735666895194,1.25169257628534,-5.20410211928349,0.648348610921428,"CCDC186","coiled-coil domain containing 186",TRUE
+"1554683_a_at",0.358427723880268,0.00973041325093876,-2.8288727029139,-2.65017400498725,-1.41333063563525,"CCDC187","coiled-coil domain containing 187",TRUE
+"1554681_a_at",0.82329144151215,0.390111483324508,0.876596058587106,-5.57218819357988,0.230939322321336,"CCDC187","coiled-coil domain containing 187",TRUE
+"231300_at",0.955203530479627,0.795225501607164,-0.262678382572117,-5.90613192583678,-0.149848716070815,"CCDC189","coiled-coil domain containing 189",TRUE
+"1554960_at",0.834454640870101,0.412853296324214,0.83459691792673,-5.60599666134218,1.19587031799326,"CCDC190","coiled-coil domain containing 190",TRUE
+"228476_at",0.906507435035949,0.61447791043773,0.510894742140029,-5.81334689378344,0.30347556100245,"CCDC191","coiled-coil domain containing 191",TRUE
+"206016_at",0.635916735157933,0.107025659120785,-1.67989064298227,-4.65137519134067,-0.66420407817524,"CCDC22","coiled-coil domain containing 22",TRUE
+"214037_s_at",0.713633547141264,0.188727172855876,-1.35610151348718,-5.08158913742856,-0.545174948016493,"CCDC22","coiled-coil domain containing 22",TRUE
+"228994_at",0.877948371309952,0.529609113633115,0.638632018501566,-5.74296315754059,0.514324803120966,"CCDC24","coiled-coil domain containing 24",TRUE
+"218125_s_at",0.94632739401154,0.757235628640252,0.312962980986299,-5.89208995445423,0.111132095970216,"CCDC25","coiled-coil domain containing 25",TRUE
+"222525_s_at",0.946727564264032,0.758511397910866,-0.311261644781361,-5.89260480521059,-0.111762698166649,"CCDC25","coiled-coil domain containing 25",TRUE
+"1553849_at",0.812302873476553,0.357434537991202,0.939838166623735,-5.518383439874,0.655259172098783,"CCDC26","CCDC26 long non-coding RNA",TRUE
+"1552948_at",0.534511365932792,0.042464080001582,2.15298359893573,-3.90361460809814,0.587172466924261,"CCDC27","coiled-coil domain containing 27",TRUE
+"209479_at",0.697713925841949,0.168679102588444,1.42294939650452,-4.99885201727323,0.525087150581893,"CCDC28A","coiled-coil domain containing 28A",TRUE
+"221912_s_at",0.762857166457304,0.262671221138092,1.1493412681291,-5.31598034372904,0.932478434490664,"CCDC28B","coiled-coil domain containing 28B",TRUE
+"219585_at",0.998870448604467,0.995630927770451,0.00553796306756175,-5.93966854300398,0.00485345979851282,"CCDC28B","coiled-coil domain containing 28B",TRUE
+"223316_at",0.663789119801086,0.13176229203843,1.56496650855253,-4.81240052901854,1.41922863972907,"CCDC3","coiled-coil domain containing 3",TRUE
+"243036_at",0.921006039723366,0.663812717836149,0.440542070269721,-5.84559512371901,0.450428854513518,"CCDC30","coiled-coil domain containing 30",TRUE
+"221171_at",0.969635809626525,0.854911089873914,0.185001180220754,-5.92302726788461,0.0798107807958219,"CCDC30","coiled-coil domain containing 30",TRUE
+"230897_at",0.710372201621696,0.18321439954733,-1.3738980823406,-5.05988501612444,-1.04689605709679,"CCDC30///PPCS","coiled-coil domain containing 30///phosphopantothenoylcysteine synthetase",TRUE
+"1563090_at",0.812302873476553,0.360525949112679,0.933694518436846,-5.52376164191293,0.295793415350641,"CCDC33","coiled-coil domain containing 33",TRUE
+"220908_at",0.846928534985425,0.445603578617385,0.776605623006047,-5.65012120194673,0.430748926744085,"CCDC33","coiled-coil domain containing 33",TRUE
+"226287_at",0.945498722604777,0.754392981708474,-0.316757269757526,-5.89093173093086,-0.160268142441982,"CCDC34","coiled-coil domain containing 34",TRUE
+"1553666_at",0.993225426079816,0.96831246401193,0.0401762198248308,-5.93889732878166,0.0209186014094458,"CCDC34","coiled-coil domain containing 34",TRUE
+"1569690_at",0.623667408398064,0.0952321471776998,1.74280255880144,-4.55956897395955,0.482737865427183,"CCDC36","coiled-coil domain containing 36",TRUE
+"1554909_at",0.828607509614823,0.39918287328383,-0.859659432610545,-5.58600779282769,-0.711422884257666,"CCDC36","coiled-coil domain containing 36",TRUE
+"1564600_a_at",0.975398143273847,0.881621321503693,-0.150641789133578,-5.92863662272546,-0.104611157202407,"CCDC36","coiled-coil domain containing 36",TRUE
+"237272_at",0.51531387545335,0.0358412622228907,2.23465431794045,-3.76231858916193,0.990424340831511,"CCDC37-AS1","CCDC37 antisense RNA 1 (head to head)",TRUE
+"237734_s_at",0.740610299769501,0.230603276000944,1.23271243802076,-5.2254727105809,0.463689569457942,"CCDC37-AS1","CCDC37 antisense RNA 1 (head to head)",TRUE
+"237735_at",0.901788521024914,0.599473692109886,-0.5328028659662,-5.80235443421196,-0.305131800138607,"CCDC37-AS1","CCDC37 antisense RNA 1 (head to head)",TRUE
+"1557620_a_at",0.834881450121645,0.413612486897142,0.833220647974042,-5.60707832268778,0.317609131317698,"CCDC38","coiled-coil domain containing 38",TRUE
+"239254_at",0.525405708458677,0.0393695470366348,-2.18958826584106,-3.84068576803439,-1.51992778852051,"CCDC40","coiled-coil domain containing 40",TRUE
+"229918_at",0.698391916012681,0.169617447978126,1.41968294461027,-5.00297115234609,1.02739851050285,"CCDC40","coiled-coil domain containing 40",TRUE
+"1563563_at",0.919695424525124,0.658713922425446,0.447703390071101,-5.84252610603812,0.35551738068762,"CCDC40","coiled-coil domain containing 40",TRUE
+"220593_s_at",0.956128647557333,0.801556702138782,0.254368576968796,-5.90821789897712,0.119697024761176,"CCDC40","coiled-coil domain containing 40",TRUE
+"220592_at",0.973684290975695,0.873268573551005,0.161364638251898,-5.92700901696892,0.094589217533465,"CCDC40","coiled-coil domain containing 40",TRUE
+"230881_at",0.97928472590149,0.899846655755098,-0.12730584520772,-5.9317928382031,-0.0742679140196358,"CCDC42","coiled-coil domain containing 42",TRUE
+"225607_at",0.871744769522775,0.51342321474433,-0.664188027370028,-5.72707198246675,-0.189340214763435,"CCDC43","coiled-coil domain containing 43",TRUE
+"222432_s_at",0.877546037473893,0.528020186168417,-0.641121658296231,-5.74144138052374,-0.276222381670284,"CCDC47","coiled-coil domain containing 47",TRUE
+"217814_at",0.92071388341937,0.662627720140262,-0.442204313509952,-5.84488708885797,-0.135814470067578,"CCDC47","coiled-coil domain containing 47",TRUE
+"225331_at",0.516444287133032,0.0363386966160033,2.22806263989803,-3.77384158151572,1.15757340623869,"CCDC50","coiled-coil domain containing 50",TRUE
+"235051_at",0.634743115037769,0.105667287498987,1.68682735837786,-4.64137701976215,1.28403777869119,"CCDC50","coiled-coil domain containing 50",TRUE
+"236831_at",0.689848451630875,0.158931835888721,1.45777474598175,-4.95445528222201,0.990664336362915,"CCDC50","coiled-coil domain containing 50",TRUE
+"228693_at",0.724853010944214,0.202397371520517,1.31367182768952,-5.13237714607361,0.76513574337582,"CCDC50","coiled-coil domain containing 50",TRUE
+"226713_at",0.82153774281298,0.384015200691341,0.888122157231742,-5.56264028402449,0.535591048170104,"CCDC50","coiled-coil domain containing 50",TRUE
+"218722_s_at",0.737651450894455,0.224459735193311,-1.24967067420312,-5.20639202747396,-0.480477780401834,"CCDC51","coiled-coil domain containing 51",TRUE
+"218628_at",0.955735662836499,0.797954075999894,-0.259094800712839,-5.90703966613426,-0.0962148818563335,"CCDC53","coiled-coil domain containing 53",TRUE
+"244735_at",0.709135917979769,0.181716468430787,1.37880686423762,-5.05385699896613,1.03800413828929,"CCDC54","coiled-coil domain containing 54",TRUE
+"227783_at",0.606900628956089,0.080535376955418,-1.8313084900994,-4.42622102115153,-1.55766537651461,"CCDC57","coiled-coil domain containing 57",TRUE
+"1553248_at",0.781142363716097,0.302813212601055,1.05495743736354,-5.41168152025662,0.355618408503082,"CCDC57","coiled-coil domain containing 57",TRUE
+"1554554_at",0.784925710185113,0.309978290191473,-1.0390716494482,-5.42706822005301,-0.432200619661039,"CCDC57","coiled-coil domain containing 57",TRUE
+"234661_at",0.804772751556177,0.343808839662699,0.967353106620141,-5.49390029312202,0.307945659966552,"CCDC57","coiled-coil domain containing 57",TRUE
+"214818_at",0.98451040420843,0.924365831596035,0.0960226138242699,-5.93519358955695,0.0598592705161236,"CCDC57","coiled-coil domain containing 57",TRUE
+"235244_at",0.657015752622694,0.125487761097365,-1.59228661573958,-4.77492237460082,-0.998581816218723,"CCDC58","coiled-coil domain containing 58",TRUE
+"218936_s_at",0.672434875127089,0.138389526212848,-1.5372565778873,-4.84989165665504,-0.548445744231671,"CCDC59","coiled-coil domain containing 59",TRUE
+"222792_s_at",0.758991118684188,0.25657010764512,-1.16459335167575,-5.29983637681445,-0.400522720450407,"CCDC59","coiled-coil domain containing 59",TRUE
+"225010_at",0.776983560547865,0.296018252013453,-1.07027135860108,-5.39665050545438,-0.424645439344992,"CCDC6","coiled-coil domain containing 6",TRUE
+"204716_at",0.965914344760007,0.840411729210394,-0.203745977252108,-5.91948451247815,-0.0788291040691096,"CCDC6","coiled-coil domain containing 6",TRUE
+"1554117_at",0.873337356017718,0.518523589411014,0.65608773060752,-5.73217364526566,0.366997005969747,"CCDC60","coiled-coil domain containing 60",TRUE
+"228475_at",0.429284714913652,0.0189462829607841,2.53161745280945,-3.22330954021081,0.792270117045047,"CCDC61","coiled-coil domain containing 61",TRUE
+"228887_x_at",0.937113154905832,0.720785162169079,0.361995293537312,-5.8760592057302,0.167919029715567,"CCDC61","coiled-coil domain containing 61",TRUE
+"228472_at",0.986249924471866,0.932549585648771,-0.0856046120481028,-5.93611483947401,-0.0385099406451737,"CCDC61","coiled-coil domain containing 61",TRUE
+"231567_s_at",0.71454754703986,0.189825279742331,1.3526056738294,-5.08582479000933,0.759223169813351,"CCDC62","coiled-coil domain containing 62",TRUE
+"244833_at",0.710824498521146,0.184076381665485,1.37108772326708,-5.06332810893351,1.05364497820962,"CCDC63","coiled-coil domain containing 63",TRUE
+"1552320_a_at",0.71454754703986,0.189591453867276,-1.35334872471499,-5.08492525464478,-1.01040548763006,"CCDC65","coiled-coil domain containing 65",TRUE
+"1561523_at",0.871959063104412,0.514539266678187,-0.662411736988455,-5.72819584802855,-0.431727490457201,"CCDC65","coiled-coil domain containing 65",TRUE
+"1552321_a_at",0.969642324744141,0.855253792606973,-0.184558980008198,-5.92310673274954,-0.0868587159781748,"CCDC65","coiled-coil domain containing 65",TRUE
+"1560177_at",0.837368340567858,0.420995503865298,0.819919004547233,-5.61744646562401,0.298339498758589,"CCDC66","coiled-coil domain containing 66",TRUE
+"228122_at",0.867834927246481,0.500963179853425,0.684167728828501,-5.71423233464063,0.250867595227218,"CCDC66","coiled-coil domain containing 66",TRUE
+"220180_at",0.777562247899264,0.296575822911591,-1.0690053589295,-5.39790047299702,-1.45760971921984,"CCDC68","coiled-coil domain containing 68",TRUE
+"212886_at",0.962646556512271,0.83003029786305,-0.217212736534304,-5.91672926612981,-0.217768275081279,"CCDC69","coiled-coil domain containing 69",TRUE
+"1553102_a_at",0.967999456920017,0.848935966334061,0.192717224208449,-5.92161016386132,0.216345302195564,"CCDC69","coiled-coil domain containing 69",TRUE
+"220749_at",0.527826453640453,0.040375572700531,2.17741079943174,-3.86169362209608,1.16793864180261,"CCDC7","coiled-coil domain containing 7",TRUE
+"1553214_a_at",0.755049574909504,0.248781396793462,1.18446063370248,-5.27852800162828,1.31488293472814,"CCDC7","coiled-coil domain containing 7",TRUE
+"1553215_s_at",0.773234064853267,0.284565435074558,1.09666284837407,-5.37029262601324,0.592129750472569,"CCDC7","coiled-coil domain containing 7",TRUE
+"221167_s_at",0.897560972979555,0.584452096800547,0.555003972183224,-5.79075717979564,0.452546089294954,"CCDC70","coiled-coil domain containing 70",TRUE
+"219893_at",0.961981011884773,0.827146727802437,0.220960487603677,-5.91593127505596,0.0831436342617007,"CCDC71","coiled-coil domain containing 71",TRUE
+"227883_at",0.390513636917105,0.0130635471773459,2.69884366471175,-2.90452031328304,2.89713890188417,"CCDC71L","coiled-coil domain containing 71-like",TRUE
+"229521_at",0.47984873377716,0.0269609540158178,2.36909069193813,-3.52296735665805,1.21652695838753,"CCDC71L","coiled-coil domain containing 71-like",TRUE
+"226756_at",0.522667179791589,0.0385488540280139,2.19973319209536,-3.82312932766376,1.66305340015505,"CCDC71L","coiled-coil domain containing 71-like",TRUE
+"228668_x_at",0.998347572104896,0.99257387992482,-0.00941298096578971,-5.93964032499703,-0.00574836000210954,"CCDC71L","coiled-coil domain containing 71-like",TRUE
+"231657_s_at",0.871744769522775,0.514293117556623,0.662803319724529,-5.72794834001699,0.380106641145708,"CCDC74B///CCDC74A","coiled-coil domain containing 74B///coiled-coil domain containing 74A",TRUE
+"227966_s_at",0.960388681678405,0.820322118391645,0.229843388720951,-5.91398562398918,0.341776209903357,"CCDC74B///CCDC74A","coiled-coil domain containing 74B///coiled-coil domain containing 74A",TRUE
+"224521_s_at",0.587626678796111,0.0666750151838954,1.92871550656784,-4.27403618634345,0.661288556313414,"CCDC77","coiled-coil domain containing 77",TRUE
+"236745_at",0.330171916405281,0.00798591290652461,-2.91503833647428,-2.47884750503198,-2.06982304619221,"CCDC78","coiled-coil domain containing 78",TRUE
+"223496_s_at",0.54295328972902,0.0457119025051739,2.11707199602563,-3.9647046711442,2.42512691540103,"CCDC8","coiled-coil domain containing 8",TRUE
+"223495_at",0.55074985379986,0.0491090986844034,2.08188724998051,-4.02392218665806,1.31342358129315,"CCDC8","coiled-coil domain containing 8",TRUE
+"225242_s_at",0.624374299616567,0.0959139394379499,1.73898947506399,-4.56520494503422,2.45873446044707,"CCDC80","coiled-coil domain containing 80",TRUE
+"225241_at",0.647754107214051,0.119146965417237,1.6210764483095,-4.73488226436248,2.04221608040183,"CCDC80","coiled-coil domain containing 80",TRUE
+"243864_at",0.936992192746977,0.718745449884306,0.364764822598276,-5.87508505559072,0.281990057114998,"CCDC80","coiled-coil domain containing 80",TRUE
+"220389_at",0.877740599174557,0.528530106669317,-0.640322236448991,-5.7419306425252,-0.376269023938574,"CCDC81","coiled-coil domain containing 81",TRUE
+"223301_s_at",0.54295328972902,0.0458478558033201,2.11561946014416,-3.96716191073094,2.54362869545241,"CCDC82","coiled-coil domain containing 82",TRUE
+"223300_s_at",0.548504186940293,0.0483955124968378,2.08909243342466,-4.01184748422189,2.10240047415014,"CCDC82","coiled-coil domain containing 82",TRUE
+"1554785_at",0.819780516863333,0.377385270643032,0.90079392479969,-5.55201006549481,1.01467397925111,"CCDC82","coiled-coil domain containing 82",TRUE
+"220693_at",0.902962996687185,0.602668965251189,0.52811554381754,-5.80474409719937,0.235499962733259,"CCDC82","coiled-coil domain containing 82",TRUE
+"237160_at",0.623503825356688,0.0944066391399317,-1.74745080160956,-4.55268622960029,-2.56430256435736,"CCDC83","coiled-coil domain containing 83",TRUE
+"227208_at",0.743553048228796,0.234079198512906,1.22326937009686,-5.23600019359275,0.668157896153081,"CCDC84","coiled-coil domain containing 84",TRUE
+"233846_at",0.837368340567858,0.42096126449741,-0.819980351927218,-5.61739900624974,-0.636459068749352,"CCDC85A","coiled-coil domain containing 85A",TRUE
+"235228_at",0.886567073863495,0.549532817845402,0.607749406853806,-5.76136588395486,0.965477692045035,"CCDC85A","coiled-coil domain containing 85A",TRUE
+"213250_at",0.579036829255831,0.0619465209138753,1.96604696121269,-4.21426388124223,1.13627239805354,"CCDC85B","coiled-coil domain containing 85B",TRUE
+"204609_at",0.821710721148425,0.384372362787606,0.887443599608642,-5.56320558562679,0.548443663766299,"CCDC85B","coiled-coil domain containing 85B",TRUE
+"204610_s_at",0.957017346544368,0.805397755834839,0.249336074839993,-5.90944878854273,0.148384877761625,"CCDC85B","coiled-coil domain containing 85B",TRUE
+"222809_x_at",0.831875452294783,0.407774924498445,-0.843844600806915,-5.59868531779282,-0.318933034689856,"CCDC85C","coiled-coil domain containing 85C",TRUE
+"219018_s_at",0.91876780831279,0.655032748502316,0.452888444528544,-5.84027373376311,0.122688336058484,"CCDC85C","coiled-coil domain containing 85C",TRUE
+"203119_at",0.956734254923335,0.803524664211298,-0.251789346522143,-5.90885180155056,-0.114156681874908,"CCDC86","coiled-coil domain containing 86",TRUE
+"219887_at",0.995967865627306,0.98018463700293,-0.0251193428646169,-5.93937615765317,-0.0153333693660773,"CCDC87","coiled-coil domain containing 87",TRUE
+"219387_at",0.471258057520525,0.0256169783944769,2.39290938861297,-3.47972959501242,2.38235258361623,"CCDC88A","coiled-coil domain containing 88A",TRUE
+"225045_at",0.500677386446044,0.0320139768103881,2.28836085398012,-3.66767835094464,4.29820098589406,"CCDC88A","coiled-coil domain containing 88A",TRUE
+"1562648_at",0.597654932724127,0.0737280286488525,1.87714493165737,-4.35529930464341,1.92580372901717,"CCDC88A","coiled-coil domain containing 88A",TRUE
+"221078_s_at",0.606900628956089,0.0803869187475363,1.83227153118064,-4.42474379007196,2.04947920988636,"CCDC88A","coiled-coil domain containing 88A",TRUE
+"238759_at",0.610033432202476,0.0822730866827123,1.82014906602357,-4.4432980487889,1.86887088395993,"CCDC88A","coiled-coil domain containing 88A",TRUE
+"239233_at",0.724067243569133,0.201341325079085,1.31686831779921,-5.12859832657329,1.88798951965322,"CCDC88A","coiled-coil domain containing 88A",TRUE
+"223663_at",0.944654135079729,0.751141109932196,-0.321103610459654,-5.88958800629023,-0.147924297812965,"CCDC88B","coiled-coil domain containing 88B",TRUE
+"227228_s_at",0.864894115958506,0.493740937702342,-0.695877380125041,-5.7065382941097,-0.465906066724209,"CCDC88C","coiled-coil domain containing 88C",TRUE
+"215343_at",0.86679822545543,0.49816442221714,0.688693969990091,-5.71127307048012,0.411324595659852,"CCDC88C","coiled-coil domain containing 88C",TRUE
+"231288_at",0.999357794096444,0.997912528489026,-0.00264593759620271,-5.93968007082764,-0.00158978490590922,"CCDC88C","coiled-coil domain containing 88C",TRUE
+"1553228_at",0.994536266629158,0.974780866977884,0.0319717187798032,-5.93918562156151,0.027131997120371,"CCDC89","coiled-coil domain containing 89",TRUE
+"206257_at",0.960029104619887,0.819101924122782,0.231433565283817,-5.91362927124161,0.0524274555140973,"CCDC9","coiled-coil domain containing 9",TRUE
+"1568834_s_at",0.667350296981039,0.133885055465661,1.55596784915072,-4.82463351388306,0.556219949520153,"CCDC90B","coiled-coil domain containing 90B",TRUE
+"218288_s_at",0.719333457476224,0.195321893181381,1.33534236965903,-5.10660714197919,0.615954571591846,"CCDC90B","coiled-coil domain containing 90B",TRUE
+"222577_at",0.99186228645105,0.962385147762535,0.0476968764893422,-5.93857547675737,0.026865676418601,"CCDC90B","coiled-coil domain containing 90B",TRUE
+"218545_at",0.761748280722165,0.261075364162852,1.15330520456463,-5.31180258745557,0.538556165050723,"CCDC91","coiled-coil domain containing 91",TRUE
+"1570571_at",0.7717895132349,0.281342892073675,1.10422661768176,-5.36263310736486,1.11311905354109,"CCDC91","coiled-coil domain containing 91",TRUE
+"218175_at",0.660068911122272,0.128041899796302,-1.58103160320816,-4.79042364163714,-1.00769969720544,"CCDC92","coiled-coil domain containing 92",TRUE
+"209689_at",0.848268984089208,0.448010293103043,0.77244922592701,-5.6531688777657,0.247111162781158,"CCDC93","coiled-coil domain containing 93",TRUE
+"243282_at",0.919441662700044,0.657777057823726,-0.44902180682876,-5.84195580111387,-0.38116910509552,"CCDC93","coiled-coil domain containing 93",TRUE
+"209688_s_at",0.92346045063848,0.671536313176835,0.429738456536816,-5.85013313199293,0.138517906622706,"CCDC93","coiled-coil domain containing 93",TRUE
+"219774_at",0.978438107398701,0.896256895723115,0.131896078741842,-5.93121380071672,0.0377457577091018,"CCDC93","coiled-coil domain containing 93",TRUE
+"204335_at",0.547793752989355,0.048244778720157,-2.09062659700763,-4.00927300471874,-0.657350932002978,"CCDC94","coiled-coil domain containing 94",TRUE
+"238682_at",0.506191505604384,0.0332158786795855,-2.27089055863259,-3.69861025139905,-0.754475438428511,"CCDC96","coiled-coil domain containing 96",TRUE
+"225257_at",0.55937703282623,0.0533201422717623,-2.04118392446452,-4.09162390920982,-0.807040372972185,"CCDC97","coiled-coil domain containing 97",TRUE
+"235495_at",0.702809964629668,0.174677359110243,-1.40231415916748,-5.02474312429288,-0.991941449634368,"CCDC97","coiled-coil domain containing 97",TRUE
+"225254_at",0.783862955202613,0.306821236475375,-1.0460387985513,-5.42034580119397,-0.378095848485414,"CCDC97","coiled-coil domain containing 97",TRUE
+"228679_at",0.953564723226096,0.786155038674355,0.274616695784114,-5.90301854736581,0.179468423245567,"CCEPR","cervical carcinoma expressed PCNA regulatory lncRNA",TRUE
+"236968_at",0.928295253101366,0.685051761049029,-0.410956748883588,-5.85775870110784,-0.171809470426243,"CCER1","coiled-coil glutamate rich protein 1",TRUE
+"37425_g_at",0.758991118684188,0.256557259456173,1.16462575275463,-5.29980188234063,0.395210198723253,"CCHCR1","coiled-coil alpha-helical rod protein 1",TRUE
+"209698_at",0.75959865506602,0.257465374206954,1.16233859081179,-5.30223474891516,0.462427668789752,"CCHCR1","coiled-coil alpha-helical rod protein 1",TRUE
+"42361_g_at",0.773107052530371,0.283809579738168,1.09843135963056,-5.36850592020653,0.486725866142679,"CCHCR1","coiled-coil alpha-helical rod protein 1",TRUE
+"37424_at",0.834454640870101,0.4127943168891,0.834703903619997,-5.60591250743225,0.316564505054934,"CCHCR1","coiled-coil alpha-helical rod protein 1",TRUE
+"210642_at",0.989654520357877,0.95023781070712,-0.0631188787715653,-5.93774321100133,-0.0397048427331188,"CCIN","calicin",TRUE
+"205827_at",0.980025041090473,0.906214770117881,0.119169746778229,-5.93276885481516,0.14075203650492,"CCK","cholecystokinin",TRUE
+"211173_at",0.700595163479743,0.172361596006273,1.41021269337894,-5.01486956806034,0.79118159953204,"CCKAR","cholecystokinin A receptor",TRUE
+"211174_s_at",0.910165867297668,0.626444575515527,0.493602131031958,-5.82170563024658,0.407064968732824,"CCKAR","cholecystokinin A receptor",TRUE
+"234475_x_at",0.568731573107512,0.0586762169686858,1.99336864067481,-4.17002558388857,0.950031061279207,"CCKBR","cholecystokinin B receptor",TRUE
+"210381_s_at",0.91539387234353,0.64331219297536,-0.469482417721676,-5.83289456267216,-0.289948787282295,"CCKBR","cholecystokinin B receptor",TRUE
+"207533_at",0.9202957869034,0.66084793858834,0.444703265809648,-5.84381773309422,0.181040035232669,"CCL1","C-C motif chemokine ligand 1",TRUE
+"210133_at",0.979883160726582,0.904071384879612,0.121907253838697,-5.93244764249317,0.0937220258468106,"CCL11","C-C motif chemokine ligand 11",TRUE
+"216714_at",0.820536502908875,0.380445507781424,-0.8949268909725,-5.556949185692,-0.315039352150877,"CCL13","C-C motif chemokine ligand 13",TRUE
+"206407_s_at",0.965992617204023,0.840880148843324,0.203139271712328,-5.91960450924427,0.119242337488648,"CCL13","C-C motif chemokine ligand 13",TRUE
+"205392_s_at",0.971242929121865,0.863404039348825,-0.17405334001598,-5.92493887782938,-0.133667398259553,"CCL15-CCL14///CCL14","CCL15-CCL14 readthrough (NMD candidate)///C-C motif chemokine ligand 14",TRUE
+"210390_s_at",0.640987277293074,0.111526510633544,-1.65742642654581,-4.68353912362816,-1.28747335703342,"CCL15-CCL14///CCL15","CCL15-CCL14 readthrough (NMD candidate)///C-C motif chemokine ligand 15",TRUE
+"207354_at",0.968066640321622,0.849582531517503,-0.191881705534794,-5.92176639803049,-0.110583910587954,"CCL16","C-C motif chemokine ligand 16",TRUE
+"207900_at",0.772700799794446,0.283182521654859,1.09990110614461,-5.36701910484797,0.388837674743353,"CCL17","C-C motif chemokine ligand 17",TRUE
+"32128_at",0.73043832713297,0.213126339876585,1.28190963725691,-5.16950247164449,1.03290032352726,"CCL18","C-C motif chemokine ligand 18",TRUE
+"209924_at",0.843475287501313,0.438456281122502,0.789030361635836,-5.64091885016441,0.577858848354379,"CCL18","C-C motif chemokine ligand 18",TRUE
+"210072_at",0.818715626618207,0.37235004405646,0.91051602364929,-5.54375994597523,0.439651916893552,"CCL19","C-C motif chemokine ligand 19",TRUE
+"216598_s_at",0.996437521591612,0.982430071677534,-0.0222723490964264,-5.93944187230187,-0.0336092809641801,"CCL2","C-C motif chemokine ligand 2",TRUE
+"205476_at",0.597654932724127,0.0747937499962156,1.86973172508846,-4.3668537969242,2.41401327765816,"CCL20","C-C motif chemokine ligand 20",TRUE
+"204606_at",0.929126743655924,0.688477271871912,-0.406220550488588,-5.85962873317722,-0.272761445832462,"CCL21","C-C motif chemokine ligand 21",TRUE
+"207861_at",0.588653540532996,0.0673931771341806,1.92325105292537,-4.28271932631558,0.696626341498312,"CCL22","C-C motif chemokine ligand 22",TRUE
+"210548_at",0.73759219552868,0.22440500667243,1.2498233249469,-5.20621925358346,1.04485033323342,"CCL23","C-C motif chemokine ligand 23",TRUE
+"210549_s_at",0.931582451098271,0.698103169012971,-0.392961576748559,-5.86475037172285,-0.290421683367681,"CCL23","C-C motif chemokine ligand 23",TRUE
+"221463_at",0.884815577925557,0.544904338660922,0.614869740218642,-5.7572008803267,0.359373421788079,"CCL24","C-C motif chemokine ligand 24",TRUE
+"206988_at",0.713633547141264,0.188526763564322,1.35674124780103,-5.08081302934663,0.651906395972982,"CCL25","C-C motif chemokine ligand 25",TRUE
+"223710_at",0.996140682541913,0.98076358631758,-0.0243852717949581,-5.93939385695849,-0.0214256914449171,"CCL26","C-C motif chemokine ligand 26",TRUE
+"207955_at",0.819018525257656,0.373949280830854,0.907418826131807,-5.54639708775925,0.561136610530815,"CCL27","C-C motif chemokine ligand 27",TRUE
+"238750_at",0.90466378569832,0.608802181749551,-0.519151721375305,-5.80925672170188,-0.580476008896355,"CCL28","C-C motif chemokine ligand 28",TRUE
+"224027_at",0.937462538530338,0.722788445020361,-0.359278033781092,-5.87700784535887,-0.358775406495449,"CCL28","C-C motif chemokine ligand 28",TRUE
+"224240_s_at",0.975398143273847,0.881261532260617,-0.151103287257322,-5.92856887119068,-0.11306228899959,"CCL28","C-C motif chemokine ligand 28",TRUE
+"205114_s_at",0.996200785753073,0.98100503181512,-0.0240791382748687,-5.93940108310529,-0.0210668944883929,"CCL3L3///CCL3L1///CCL3","C-C motif chemokine ligand 3 like 3///C-C motif chemokine ligand 3 like 1///C-C motif chemokine ligand 3",TRUE
+"204103_at",0.983136574792668,0.91795734885084,0.104188225567074,-5.93439770239955,0.0517466487205533,"CCL4","C-C motif chemokine ligand 4",TRUE
+"1555759_a_at",0.448431337488385,0.0213327829685832,2.47741623011528,-3.32442214253132,3.01344991466524,"CCL5","C-C motif chemokine ligand 5",TRUE
+"204655_at",0.561084367279569,0.0546370702844477,2.02904384301153,-4.11164651912838,2.28874534572995,"CCL5","C-C motif chemokine ligand 5",TRUE
+"1405_i_at",0.631294544151106,0.102338150559227,1.70415342451349,-4.61626865673992,2.75356004938973,"CCL5","C-C motif chemokine ligand 5",TRUE
+"208075_s_at",0.900095307417541,0.594713177511818,0.539808840962496,-5.79874439559869,0.419680342804627,"CCL7","C-C motif chemokine ligand 7",TRUE
+"214038_at",0.675334226639578,0.141480112331004,1.52470662464396,-4.8666969079472,1.28098348464584,"CCL8","C-C motif chemokine ligand 8",TRUE
+"223164_at",0.991367768700244,0.959601499442391,-0.051229752018037,-5.93840527049936,-0.015830457364979,"CCM2","CCM2 scaffolding protein",TRUE
+"231991_at",0.468374648894481,0.0246458868746122,-2.41084910839344,-3.44700555751217,-2.08748669637749,"CCM2L","CCM2 like scaffolding protein",TRUE
+"1570070_at",0.623503825356688,0.0944104275400841,1.74742939066048,-4.55271796429345,0.514227306199103,"CCM2L","CCM2 like scaffolding protein",TRUE
+"205899_at",0.0714602469656225,0.000214348065886824,4.41770560748827,0.701531217787183,3.35427307915054,"CCNA1","cyclin A1",TRUE
+"203418_at",0.808257777979515,0.350595109731545,0.953558715307081,-5.50625557032855,0.395210605871538,"CCNA2","cyclin A2",TRUE
+"213226_at",0.896690757315733,0.581602139206586,0.55924772817188,-5.78848802547355,0.203489574703157,"CCNA2","cyclin A2",TRUE
+"228729_at",0.815195559141692,0.366155876385947,-0.922596089800777,-5.53339507619739,-0.323640046394591,"CCNB1","cyclin B1",TRUE
+"214710_s_at",0.895213601869362,0.573384026206319,0.571543702567668,-5.78181867791639,0.177688842449294,"CCNB1","cyclin B1",TRUE
+"217988_at",0.679867195513467,0.147090060461432,1.50248997546086,-4.89617706856044,0.69447248393984,"CCNB1IP1","cyclin B1 interacting protein 1",TRUE
+"232764_at",0.661974206478491,0.129676795125808,1.57392487119144,-4.80016728111183,0.697214192632348,"CCNB2","cyclin B2",TRUE
+"232768_at",0.736094223891156,0.221373522148007,1.25832365469846,-5.19656979688632,0.738737757844777,"CCNB2","cyclin B2",TRUE
+"202705_at",0.819018525257656,0.374896874734386,-0.905587778995239,-5.54795224994269,-0.263271955097553,"CCNB2","cyclin B2",TRUE
+"231481_at",0.657015752622694,0.125430574876449,1.59254078505837,-4.77457132290241,0.964032745987913,"CCNB3","cyclin B3",TRUE
+"201955_at",0.493378740589161,0.0297360677739779,2.32318712967331,-3.6056047314957,0.758067581201114,"CCNC","cyclin C",TRUE
+"1569126_at",0.805746717966166,0.34571999888462,-0.963449707259944,-5.49741292333665,-0.717487338348267,"CCNC","cyclin C",TRUE
+"208712_at",0.97070558355376,0.860477835296617,0.177822837531528,-5.92429380168511,0.169651956503959,"CCND1","cyclin D1",TRUE
+"208711_s_at",0.979388236370534,0.900727503432503,0.126179935249864,-5.93193173952205,0.124134430576969,"CCND1","cyclin D1",TRUE
+"200952_s_at",0.571390900668275,0.0592144594748171,1.9887806143358,-4.17748312231082,1.33533513552138,"CCND2","cyclin D2",TRUE
+"200953_s_at",0.673366993714442,0.139484777269167,1.53278296254587,-4.85589468421515,1.18496095850939,"CCND2","cyclin D2",TRUE
+"231259_s_at",0.750326501261927,0.243315754318683,-1.19868143563966,-5.26308268516649,-0.577931772468237,"CCND2","cyclin D2",TRUE
+"200951_s_at",0.884227283169589,0.543204045838357,0.617493474214927,-5.75565434659336,0.397018299893358,"CCND2","cyclin D2",TRUE
+"201700_at",0.69533015659068,0.164781122877633,-1.43667671490784,-4.98145654346521,-0.522146635317203,"CCND3","cyclin D3",TRUE
+"1562028_at",0.895457620469779,0.57448505302277,0.569891210392491,-5.78272316913671,0.348928886367907,"CCND3","cyclin D3",TRUE
+"223084_s_at",0.839045421044582,0.424778661003898,0.813159801902478,-5.62265511085396,0.75057594577407,"CCNDBP1","cyclin D1 binding protein 1",TRUE
+"242105_at",0.654592482818544,0.123515659419642,-1.60110806834284,-4.76271292226776,-0.915217297177181,"CCNE1","cyclin E1",TRUE
+"213523_at",0.820611742812032,0.38120891637105,0.89346813426601,-5.5581725943344,0.61503778990143,"CCNE1","cyclin E1",TRUE
+"205034_at",0.722442821599878,0.199112773272767,-1.32365694115457,-5.12054726522388,-0.476729762638161,"CCNE2","cyclin E2",TRUE
+"211814_s_at",0.866201164475447,0.497018069170987,-0.690552059675626,-5.71005285194738,-0.270514723585617,"CCNE2","cyclin E2",TRUE
+"204826_at",0.78654895736814,0.312332225211151,-1.03390939729482,-5.43202304635202,-0.327657771249154,"CCNF","cyclin F",TRUE
+"204827_s_at",0.986455005400648,0.937198922239299,-0.0796903562197097,-5.93659083388259,-0.0222321847890186,"CCNF","cyclin F",TRUE
+"208796_s_at",0.720018659171833,0.196011311082282,-1.3332041071312,-5.10916568376833,-0.478898971814848,"CCNG1","cyclin G1",TRUE
+"1555056_at",0.717937808890208,0.19372132205154,1.34032952138017,-5.10062637653167,0.482074671539819,"CCNG2","cyclin G2",TRUE
+"228081_at",0.864894115958506,0.493283539407457,0.696622254191709,-5.70604464455053,0.316338103174118,"CCNG2","cyclin G2",TRUE
+"211559_s_at",0.909934011695618,0.625011492099648,-0.495664903199295,-5.82072330565199,-0.2735376641453,"CCNG2","cyclin G2",TRUE
+"202769_at",0.961395512423249,0.82507551096024,-0.223654425698896,-5.91534927445026,-0.130561815919178,"CCNG2","cyclin G2",TRUE
+"202770_s_at",0.964398793076854,0.835953397353294,-0.209524441298709,-5.91832376207462,-0.112351355443488,"CCNG2","cyclin G2",TRUE
+"204093_at",0.709893941953691,0.182633745701669,-1.37579712129667,-5.05755510236018,-0.577976837161083,"CCNH","cyclin H",TRUE
+"208655_at",0.819479221404744,0.376608123522596,-0.90228884118762,-5.55074681098931,-0.228468186161306,"CCNI","cyclin I",TRUE
+"208656_s_at",0.932830928398943,0.703663738719441,-0.385334994993381,-5.86762049260456,-0.113046311891001,"CCNI","cyclin I",TRUE
+"227299_at",0.96200396340887,0.827455073402257,0.22055957988544,-5.9160172874474,0.0741533410187296,"CCNI","cyclin I",TRUE
+"222888_at",0.553930058946379,0.0506333400538648,2.06680582902201,-4.04910866040856,1.1321646134645,"CCNJ","cyclin J",TRUE
+"229091_s_at",0.901218079288909,0.597875615428946,-0.535151705550249,-5.80114923557505,-0.232374622875498,"CCNJ","cyclin J",TRUE
+"219470_x_at",0.924812035112346,0.674838979037479,-0.425134648082399,-5.8520333103535,-0.214003471686771,"CCNJ","cyclin J",TRUE
+"219227_at",0.831875452294783,0.407468968043137,0.844404078768125,-5.59824057377393,0.623039145784828,"CCNJL","cyclin J like",TRUE
+"225824_at",0.766390367856479,0.266894085896285,-1.1389371154088,-5.32688548437447,-0.369553962195138,"CCNK","cyclin K",TRUE
+"219273_at",0.903906029494077,0.605545723463564,0.523905692285189,-5.80687281653452,0.250202616592645,"CCNK","cyclin K",TRUE
+"220046_s_at",0.330451674411494,0.00800820244344269,2.91382816757462,-2.48126806246851,0.820703691300366,"CCNL1","cyclin L1",TRUE
+"1555411_a_at",0.580152731323135,0.0627500107308238,1.9595299040036,-4.22475489918284,0.657246201149359,"CCNL1","cyclin L1",TRUE
+"241495_at",0.914746370982129,0.640765474095825,-0.473105664329816,-5.8312487617806,-0.257659450695773,"CCNL1","cyclin L1",TRUE
+"1555827_at",0.952959103457409,0.784537634473249,0.276749720786211,-5.90244781415546,0.121951907012805,"CCNL1","cyclin L1",TRUE
+"221427_s_at",0.922168942129244,0.667507359924281,-0.435367509222317,-5.84778247832902,-0.190426451275529,"CCNL2","cyclin L2",TRUE
+"222999_s_at",0.957571530817866,0.809487577913798,-0.243984860849419,-5.91073080926285,-0.105753896960799,"CCNL2","cyclin L2",TRUE
+"232274_at",0.990345207157428,0.951631898323407,0.0613482499292365,-5.93785053241362,0.0475576257549903,"CCNL2","cyclin L2",TRUE
+"210021_s_at",0.968153683624521,0.850340868513515,0.190901928649205,-5.92194874544854,0.16461468105299,"CCNO","cyclin O",TRUE
+"225493_at",0.734042693548791,0.218447346442293,-1.26661367803641,-5.18710511564646,-0.401024882229345,"CCNT1","cyclin T1",TRUE
+"206967_at",0.991689960875868,0.961288763111088,0.0490882795093078,-5.938509892754,0.0293271326400335,"CCNT1","cyclin T1",TRUE
+"213743_at",0.411110107932987,0.0160757796070221,-2.60598339787454,-3.08277276080628,-0.773301008900539,"CCNT2","cyclin T2",TRUE
+"214638_s_at",0.545992239117952,0.0472612890836649,-2.10074346877851,-3.99226546476225,-0.549454060065587,"CCNT2","cyclin T2",TRUE
+"204645_at",0.642592458809121,0.11309649733579,-1.64977030801872,-4.69442564216427,-0.451613203427522,"CCNT2","cyclin T2",TRUE
+"229184_at",0.913627134030439,0.637928008582075,-0.477150144888418,-5.82939699842567,-0.139319445917242,"CCNT2","cyclin T2",TRUE
+"236387_at",0.837609393049242,0.421994665126502,-0.818130162859399,-5.61882888075186,-0.618237163946793,"CCNT2-AS1","CCNT2 antisense RNA 1",TRUE
+"224651_at",0.419170456955056,0.0171983085983695,2.57552537300458,-3.14057855580481,0.786809088548111,"CCNY","cyclin Y",TRUE
+"224649_x_at",0.442317261108644,0.0205110716532574,2.49541056660209,-3.29098034899596,0.672426103156594,"CCNY","cyclin Y",TRUE
+"224647_at",0.55937703282623,0.0538431477288844,2.03633093927686,-4.09963738177689,0.669864133344259,"CCNY","cyclin Y",TRUE
+"224652_at",0.755049574909504,0.248978439672842,1.18395234271278,-5.27907708610254,0.47064737988859,"CCNY","cyclin Y",TRUE
+"1554694_at",0.779813064835198,0.300988110531718,1.05904644500083,-5.40768705511065,0.785209033994847,"CCNY","cyclin Y",TRUE
+"227280_s_at",0.163850812837738,0.00130549202003606,3.67834743447478,-0.891587352543238,2.03501411221234,"CCNYL1","cyclin Y like 1",TRUE
+"228810_at",0.374354475700726,0.011353890588372,2.76100782124687,-2.78358243562104,1.3100822464733,"CCNYL1","cyclin Y like 1",TRUE
+"1569878_at",0.327864702134751,0.00773503806548728,2.92888644405734,-2.45112064668547,2.31273684970236,"CCNYL2","cyclin Y-like 2 (pseudogene)",TRUE
+"1569353_at",0.839519981963042,0.427799736416488,0.807789136852605,-5.62676490977456,0.64977206179657,"CCP110","centriolar coiled-coil protein 110",TRUE
+"204662_at",0.997039490727282,0.984752013540138,-0.0193285497413205,-5.93950151909155,-0.00585194286465729,"CCP110","centriolar coiled-coil protein 110",TRUE
+"221156_x_at",0.714795139167042,0.190325424631223,-1.35101873132184,-5.08774455462308,-0.593056283073068,"CCPG1","cell cycle progression 1",TRUE
+"205099_s_at",0.699278997070299,0.170720283397735,1.41586234670353,-5.00777922529015,1.01019013632121,"CCR1","C-C motif chemokine receptor 1",TRUE
+"205098_at",0.968066640321622,0.849876688682861,-0.191501629585718,-5.92183724483893,-0.0649230119672399,"CCR1","C-C motif chemokine receptor 1",TRUE
+"220565_at",0.854343866520736,0.465068280323819,-0.743369153716992,-5.67405912760571,-0.899853852400906,"CCR10","C-C motif chemokine receptor 10",TRUE
+"206978_at",0.726636642789909,0.205790005033822,-1.30348990420422,-5.14436220862186,-0.893389933530995,"CCR2","C-C motif chemokine receptor 2",TRUE
+"207794_at",0.972438691973544,0.867210093552157,0.169154281730542,-5.92575666185882,0.116224713283073,"CCR2","C-C motif chemokine receptor 2",TRUE
+"208304_at",0.488355509241128,0.0290467693836699,2.33420886161764,-3.58584712213035,1.59126492072447,"CCR3","C-C motif chemokine receptor 3",TRUE
+"208376_at",0.979588787486838,0.902661392920164,0.123708598510794,-5.93223230341415,0.0823477215092074,"CCR4","C-C motif chemokine receptor 4",TRUE
+"206991_s_at",0.896159990898752,0.578938169080481,0.563223944147891,-5.78634670961567,0.391880551245426,"CCR5","C-C motif chemokine receptor 5 (gene/pseudogene)",TRUE
+"206983_at",0.95643295620889,0.802721453946293,-0.252841829958546,-5.90859390605365,-0.157536183427023,"CCR6","C-C motif chemokine receptor 6",TRUE
+"206337_at",0.903657792705527,0.605116033041331,-0.524533891337127,-5.80655621952613,-0.355439526788221,"CCR7","C-C motif chemokine receptor 7",TRUE
+"208059_at",0.713918803337953,0.189020367574215,-1.35516655902712,-5.08272284834335,-1.12987378498128,"CCR8","C-C motif chemokine receptor 8",TRUE
+"207445_s_at",0.610455440146151,0.0830166607385622,1.81543619854503,-4.4504874918074,0.751847144608684,"CCR9","C-C motif chemokine receptor 9",TRUE
+"211434_s_at",0.905462783815257,0.611500496583485,0.515221723757092,-5.81121145390035,0.472665960796672,"CCRL2","C-C motif chemokine receptor like 2",TRUE
+"203522_at",0.986145735582101,0.932050828455231,-0.0862392453689878,-5.9360617403172,-0.0333942943639425,"CCS","copper chaperone for superoxide dismutase",TRUE
+"1553698_a_at",0.645072069975909,0.115517577778597,-1.63813733417312,-4.71089314107186,-0.731515389788658,"CCSAP","centriole, cilia and spindle associated protein",TRUE
+"225904_at",0.653678932109172,0.123000744440996,-1.60343067051334,-4.75948957303716,-0.600248969068986,"CCSAP","centriole, cilia and spindle associated protein",TRUE
+"1555145_at",0.792436690618566,0.323736941089965,1.00927809999585,-5.4553576748159,0.339599412473574,"CCSAP","centriole, cilia and spindle associated protein",TRUE
+"1553697_at",0.892000472179706,0.562131303392204,-0.588526138479356,-5.77237643573813,-0.253184188887357,"CCSAP","centriole, cilia and spindle associated protein",TRUE
+"232738_at",0.902212740485572,0.600748135491235,-0.530931872146316,-5.80331075746201,-0.51150865173656,"CCSER1","coiled-coil serine rich protein 1",TRUE
+"209378_s_at",0.810515126306985,0.354610559421845,0.945481665004263,-5.51341454887098,0.278262638615404,"CCSER2","coiled-coil serine rich protein 2",TRUE
+"1554131_at",0.868397087637799,0.504243083807794,-0.678881548970954,-5.71766483401537,-0.761693434523552,"CCSER2","coiled-coil serine rich protein 2",TRUE
+"209379_s_at",0.899155703544461,0.589444538531838,0.547594627246372,-5.79467875759696,0.191674783290919,"CCSER2","coiled-coil serine rich protein 2",TRUE
+"1554132_a_at",0.902472023022503,0.601466448046035,0.529878171800195,-5.80384789550142,0.231469271325009,"CCSER2","coiled-coil serine rich protein 2",TRUE
+"201947_s_at",0.896159990898752,0.578808164960096,-0.563418221530068,-5.78624170817332,-0.174660833546922,"CCT2","chaperonin containing TCP1 subunit 2",TRUE
+"201946_s_at",0.950214160603623,0.773921245027592,-0.290783680673172,-5.89858349313914,-0.120586711471896,"CCT2","chaperonin containing TCP1 subunit 2",TRUE
+"200877_at",0.689950875648652,0.159339385025564,1.45628460170448,-4.95637287847364,0.321613751678685,"CCT4","chaperonin containing TCP1 subunit 4",TRUE
+"227171_at",0.789795896476304,0.318541779796431,1.02042170156905,-5.44486369015331,0.289850811930654,"CCT4","chaperonin containing TCP1 subunit 4",TRUE
+"208696_at",0.61760967235709,0.088300956722732,1.78295671769916,-4.499667307952,0.563025436756169,"CCT5","chaperonin containing TCP1 subunit 5",TRUE
+"229068_at",0.774011928861764,0.285666166617433,-1.09409347832254,-5.37288386526437,-0.71429536442901,"CCT5","chaperonin containing TCP1 subunit 5",TRUE
+"201327_s_at",0.846861039982617,0.445417154582169,0.776928146862947,-5.64988406640122,0.254235853541056,"CCT6A","chaperonin containing TCP1 subunit 6A",TRUE
+"201326_at",0.94895689004559,0.768961495157435,-0.297360363282182,-5.89670733814192,-0.124344406260358,"CCT6A","chaperonin containing TCP1 subunit 6A",TRUE
+"206587_at",0.921388946695144,0.66508507490734,-0.438758687344537,-5.8463518480201,-0.204244354722725,"CCT6B","chaperonin containing TCP1 subunit 6B",TRUE
+"227301_at",0.915569510513076,0.644133961157262,-0.468314640635082,-5.83342236711038,-0.136877884489776,"CCT6P1///CCT6P3","chaperonin containing TCP1 subunit 6 pseudogene 1///chaperonin containing TCP1 subunit 6 pseudogene 3",TRUE
+"200812_at",0.908709061737317,0.620797394569208,0.501743346522828,-5.81780539751936,0.153735923042184,"CCT7","chaperonin containing TCP1 subunit 7",TRUE
+"210436_at",0.538737396210242,0.0440744832784346,-2.13487885302411,-3.93449408075048,-0.956967222233284,"CCT8","chaperonin containing TCP1 subunit 8",TRUE
+"200873_s_at",0.900646880891906,0.595703578485487,0.53834904143785,-5.79950038356543,0.138985922479018,"CCT8","chaperonin containing TCP1 subunit 8",TRUE
+"220508_at",0.998347572104896,0.99236268372192,0.00968069140221719,-5.93963783534807,0.00692198211801287,"CCT8L2","chaperonin containing TCP1 subunit 8 like 2",TRUE
+"201974_s_at",0.982643521157831,0.915758392236987,-0.106991754079031,-5.93410949202619,-0.0293166681053458,"CCZ1","CCZ1 homolog, vacuolar protein trafficking and biogenesis associated",TRUE
+"215024_at",0.631316839203356,0.102638781594488,1.70256932381861,-4.61857229688456,0.806097742079201,"CCZ1B","CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated",TRUE
+"208310_s_at",0.978314802155638,0.895602514319731,0.132733147460201,-5.93110600094603,0.0410029248627755,"CCZ1B///CCZ1","CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated///CCZ1 homolog, vacuolar protein trafficking and biogenesis associated",TRUE
+"201973_s_at",0.991689960875868,0.960957341994136,0.0495088998035007,-5.9384896956502,0.0131983804418692,"CCZ1B///CCZ1","CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated///CCZ1 homolog, vacuolar protein trafficking and biogenesis associated",TRUE
+"244652_at",0.968066640321622,0.849762285704692,-0.191649444481114,-5.92180970852213,-0.106818955356496,"CD101","CD101 molecule",TRUE
+"207167_at",0.974884920935236,0.877327537679624,-0.156151599020177,-5.92781423731519,-0.114935728894848,"CD101","CD101 molecule",TRUE
+"239719_at",0.0550194051692779,9.55023384102536e-05,4.74792340246717,1.41237434302486,2.26336037834785,"CD109","CD109 molecule",TRUE
+"229900_at",0.0602075678670986,0.000135446380386888,4.60505806391439,1.10543712362186,3.18992839110913,"CD109","CD109 molecule",TRUE
+"226545_at",0.114891095515473,0.000609390355729075,3.99119240031837,-0.219683935423959,4.26285581586919,"CD109","CD109 molecule",TRUE
+"201743_at",0.898609426925686,0.588209104348302,0.549425250355188,-5.79371461629585,0.820423365555872,"CD14","CD14 molecule",TRUE
+"204306_s_at",0.863918945062466,0.490062926300224,-0.701878273168673,-5.70254701057297,-0.286953882240295,"CD151","CD151 molecule (Raph blood group)",TRUE
+"207840_at",0.929234395612144,0.688848886565784,-0.405707316415971,-5.85983009649437,-0.154784092487304,"CD160","CD160 molecule",TRUE
+"216233_at",0.620223198657182,0.0899815711282482,1.77297822314404,-4.51464664340949,0.948287166793682,"CD163","CD163 molecule",TRUE
+"215049_x_at",0.851319596585235,0.454971686936925,0.760502549067336,-5.66184275513134,0.578348002346544,"CD163","CD163 molecule",TRUE
+"203645_s_at",0.984441970220849,0.924152222357689,-0.0962946812668515,-5.93516811617211,-0.0669346170454492,"CD163","CD163 molecule",TRUE
+"223655_at",0.859122424227944,0.475975117769499,0.725107339979133,-5.68678937124636,0.88788832147196,"CD163L1","CD163 molecule like 1",TRUE
+"208405_s_at",0.95825706371645,0.811196915946556,-0.241750490233108,-5.9112579262257,-0.088563677163652,"CD164","CD164 molecule",TRUE
+"208653_s_at",0.987360737469712,0.94070072857719,0.0752377666608242,-5.936926728064,0.0289086767265498,"CD164","CD164 molecule",TRUE
+"208654_s_at",0.990259857399615,0.951445384161647,-0.0615851295475554,-5.93783635151701,-0.0232049020457161,"CD164","CD164 molecule",TRUE
+"219669_at",0.175233958083293,0.0015612168204277,3.60443833624033,-1.04919029077214,1.85831903880874,"CD177","CD177 molecule",TRUE
+"206206_at",0.710383535193614,0.183367953034979,1.37339667988758,-5.06049973577031,0.567410891069002,"CD180","CD180 molecule",TRUE
+"206398_s_at",0.951399215823566,0.777652041370621,0.285845235358641,-5.89996494205413,0.250448220679931,"CD19","CD19 molecule",TRUE
+"210325_at",0.883902273041158,0.542320725220644,0.618858257244162,-5.75484737947346,0.200654475668071,"CD1A","CD1a molecule",TRUE
+"206749_at",0.952807406768689,0.784081639739253,-0.277351321112424,-5.90228605153592,-0.140242445562173,"CD1B","CD1b molecule",TRUE
+"205987_at",0.671655467883069,0.137773772554618,1.53978447254905,-4.846493407348,0.868793280236956,"CD1C","CD1c molecule",TRUE
+"205789_at",0.790240875783718,0.319693969877068,1.01793936387485,-5.44721034341533,0.982896122780293,"CD1D","CD1d molecule",TRUE
+"215784_at",0.757950630724418,0.254219883395703,1.17054039802804,-5.29349101902827,0.913704362592128,"CD1E","CD1e molecule",TRUE
+"208592_s_at",0.997901456792957,0.990317108431036,-0.0122736850541812,-5.93961010819636,-0.00762508154462527,"CD1E","CD1e molecule",TRUE
+"205831_at",0.517859245504688,0.0369662014403506,2.21986353222663,-3.7881458250351,0.628533169121419,"CD2","CD2 molecule",TRUE
+"209583_s_at",0.904832003218088,0.610088837171643,-0.517276725472373,-5.81019112702966,-0.581139545215698,"CD200","CD200 molecule",TRUE
+"209582_s_at",0.949195855848275,0.770623774032905,0.295154685871681,-5.89734119734548,0.23474720242028,"CD200","CD200 molecule",TRUE
+"1552875_a_at",0.964503386562183,0.83611645443589,0.209312974882844,-5.91836681027103,0.129222153306597,"CD200R1","CD200 receptor 1",TRUE
+"1553395_a_at",0.988713664405312,0.945457065342161,0.0691925037554627,-5.93735188506006,0.0233981910430474,"CD200R1","CD200 receptor 1",TRUE
+"220428_at",0.836503007887803,0.418228554615839,0.824886745706537,-5.61359256729768,0.405729931294168,"CD207","CD207 molecule",TRUE
+"207278_s_at",0.504875670074508,0.0328273069431162,-2.27647450410584,-3.68873882254657,-1.3306840369975,"CD209","CD209 molecule",TRUE
+"1555729_a_at",0.689913893405055,0.159138882119062,1.45701732587297,-4.95543016941946,0.526991704010136,"CD209","CD209 molecule",TRUE
+"207277_at",0.963252094354226,0.832669112674235,-0.21378587904404,-5.91744703721856,-0.0753338943726289,"CD209","CD209 molecule",TRUE
+"217422_s_at",0.597654932724127,0.0744222609899507,-1.87230528839825,-4.3628462024916,-1.5423026835465,"CD22","CD22 molecule",TRUE
+"204581_at",0.746535697909741,0.2382898593337,-1.2119713873199,-5.24850359702515,-1.02638068893882,"CD22","CD22 molecule",TRUE
+"220674_at",0.88113080359582,0.537540315389402,-0.626264958009589,-5.75043802542686,-0.523469543721228,"CD22","CD22 molecule",TRUE
+"38521_at",0.899808883319249,0.593040554238082,-0.542276899804195,-5.79746173248717,-0.294144449720226,"CD22","CD22 molecule",TRUE
+"207315_at",0.854184492233394,0.46421697905196,0.744805141335394,-5.67304537013486,0.329154863237642,"CD226","CD226 molecule",TRUE
+"209772_s_at",0.836485547029392,0.418201003767672,0.824936313847542,-5.61355400324099,0.823582911661404,"CD24","CD24 molecule",TRUE
+"208650_s_at",0.843087230275826,0.437107955916599,0.791388157193045,-5.63915702582882,0.688473926097496,"CD24","CD24 molecule",TRUE
+"209771_x_at",0.877333806479767,0.527137295657581,0.642506794679793,-5.7405922608123,0.525174943554109,"CD24","CD24 molecule",TRUE
+"216379_x_at",0.88113080359582,0.537504393059599,0.626320748839817,-5.75040462035279,0.563421589505326,"CD24","CD24 molecule",TRUE
+"208651_x_at",0.881466832418197,0.538260476535494,0.625146900458994,-5.75110686461687,0.527954652311294,"CD24","CD24 molecule",TRUE
+"266_s_at",0.891420607788025,0.560990602247777,0.590257375288371,-5.77139884469162,0.553029982042897,"CD24","CD24 molecule",TRUE
+"234320_at",0.595363159785381,0.0720642595603045,1.88890753119549,-4.33689970848977,1.48927335975358,"CD244","CD244 molecule",TRUE
+"220307_at",0.850536169066796,0.45335483447853,-0.763267382216334,-5.65984671169334,-0.415885738395191,"CD244","CD244 molecule",TRUE
+"210031_at",0.943988850936011,0.749141959299869,0.323778737004072,-5.88875194426431,0.209857331841304,"CD247","CD247 molecule",TRUE
+"234462_at",0.947926063538122,0.76298640741795,0.305301243826525,-5.89438657892466,0.20299188875891,"CD247","CD247 molecule",TRUE
+"219025_at",0.891202647960944,0.56037779303611,0.59118818482897,-5.77087208948801,0.21917939882591,"CD248","CD248 molecule",TRUE
+"206150_at",0.828912793879547,0.399773232040417,0.858565855541378,-5.58689148654326,0.462268771602109,"CD27","CD27 molecule",TRUE
+"223834_at",0.407748633394319,0.0155486614392697,2.62098099832537,-3.05418654625564,1.70419880516809,"CD274","CD274 molecule",TRUE
+"227458_at",0.463552233135475,0.0236095753478009,2.43072999008917,-3.41058410814643,2.3429381291984,"CD274","CD274 molecule",TRUE
+"1552914_a_at",0.935571112971518,0.71308742553017,-0.37246262683014,-5.87233894996405,-0.36115301320662,"CD276","CD276 molecule",TRUE
+"1559583_at",0.961690794738111,0.826386669505777,-0.221948865765773,-5.91571856024508,-0.0979917068528326,"CD276","CD276 molecule",TRUE
+"224859_at",0.99958952638994,0.999077619545149,0.0011691458855901,-5.93968281498151,0.000762868071769063,"CD276","CD276 molecule",TRUE
+"211856_x_at",0.62952950109137,0.100369272612911,1.71462691283865,-4.60099744170542,1.18035949535812,"CD28","CD28 molecule",TRUE
+"206545_at",0.821896104057596,0.384916738023058,0.886410155971145,-5.5640657710915,0.67512786206508,"CD28","CD28 molecule",TRUE
+"211861_x_at",0.925246803459608,0.676273562495898,0.423137797733865,-5.85285123786525,0.348430359024935,"CD28","CD28 molecule",TRUE
+"236257_at",0.689989255588491,0.159514662837467,1.45564467129092,-4.95719588569079,0.553815632604961,"CD2AP","CD2 associated protein",TRUE
+"203593_at",0.859690781273454,0.477873291713998,0.721954374432523,-5.68895684189723,0.293565042360026,"CD2AP","CD2 associated protein",TRUE
+"202256_at",0.622917527985155,0.0939018978628925,-1.75031005711843,-4.54844574243118,-0.770098616177274,"CD2BP2","CD2 cytoplasmic tail binding protein 2",TRUE
+"202257_s_at",0.90344422113846,0.604267299206437,-0.525775352203506,-5.80592946707759,-0.225314789377443,"CD2BP2","CD2 cytoplasmic tail binding protein 2",TRUE
+"209933_s_at",0.673580489720054,0.139722560251088,1.53181554462273,-4.85719101078553,0.841375243654056,"CD300A","CD300a molecule",TRUE
+"217072_at",0.819780516863333,0.377600456129063,0.900380353728659,-5.55235920499801,0.590649108802849,"CD300A","CD300a molecule",TRUE
+"217078_s_at",0.91238586368984,0.633061970316669,0.484105012490438,-5.82617666668027,0.158374534696293,"CD300A","CD300a molecule",TRUE
+"207270_x_at",0.887671388121195,0.552507453299541,0.603189990158116,-5.76400830581279,0.19263125904865,"CD300C","CD300c molecule",TRUE
+"1554175_at",0.882312890445431,0.539860913341773,-0.622665073858405,-5.75258741831003,-0.302200025252902,"CD300LB","CD300 molecule like family member b",TRUE
+"1554173_at",0.937504304897146,0.723010283982567,-0.358977300473475,-5.87711240239736,-0.146841379988267,"CD300LB","CD300 molecule like family member b",TRUE
+"1553043_a_at",0.864957292343152,0.494048693935872,0.695376420634227,-5.70687001098627,0.455341537371359,"CD300LF","CD300 molecule like family member f",TRUE
+"1552509_a_at",0.832758870942732,0.409597336361003,0.840517627008887,-5.60132433439885,0.409187541926675,"CD300LG","CD300 molecule like family member g",TRUE
+"1555656_at",0.918141489589102,0.652379150645677,0.456633952086986,-5.83863087919196,0.135272242052088,"CD300LG","CD300 molecule like family member g",TRUE
+"1555636_at",0.96882227301574,0.8528987209234,-0.18759856862757,-5.92255668222432,-0.113469871759166,"CD300LG","CD300 molecule like family member g",TRUE
+"244244_at",0.986421906591669,0.936654558306882,-0.0803826675567431,-5.93653687402773,-0.0314445523136175,"CD300LG","CD300 molecule like family member g",TRUE
+"218529_at",0.697699759202153,0.168220400235585,1.42455147904834,-4.996828884857,1.83606695997713,"CD320","CD320 molecule",TRUE
+"206120_at",0.953202153239013,0.784946936395671,-0.276209811786867,-5.902592691891,-0.111642590934638,"CD33","CD33 molecule",TRUE
+"209543_s_at",0.62524538993269,0.0965616631325476,1.73538834033172,-4.57051923677389,0.713226537606812,"CD34","CD34 molecule",TRUE
+"242197_x_at",0.487553723496951,0.0287775003867006,2.33857982339443,-3.57799688426347,1.73739829366801,"CD36","CD36 molecule",TRUE
+"209554_at",0.904832003218088,0.610152470127865,0.51718404426301,-5.81023722931754,0.316919169991556,"CD36","CD36 molecule",TRUE
+"206488_s_at",0.917102138198416,0.649138715541625,0.461216789163903,-5.83660271763763,0.657960069211697,"CD36","CD36 molecule",TRUE
+"209555_s_at",0.973071267819624,0.870258044687618,0.165234093993876,-5.92639427669223,0.251235716442455,"CD36","CD36 molecule",TRUE
+"228766_at",0.998709719538178,0.994095895720172,0.00748370684519379,-5.93965620239245,0.00927181314721359,"CD36","CD36 molecule",TRUE
+"238321_at",0.323645710780045,0.00735252653517736,2.95085086165518,-2.40703839501112,1.55913912664633,"CD37","CD37 molecule",TRUE
+"204192_at",0.462669793287247,0.0233831496081013,2.43518124251704,-3.40240717476969,2.05015307334894,"CD37","CD37 molecule",TRUE
+"205692_s_at",0.740610299769501,0.230431932386828,-1.23318071480735,-5.22494884043018,-0.848244073266824,"CD38","CD38 molecule",TRUE
+"213539_at",0.999503346640971,0.99881535622674,0.00150157302261094,-5.93968238255743,0.000877639505586281,"CD3D","CD3d molecule",TRUE
+"205456_at",0.642592458809121,0.112674761697292,1.65181808350964,-4.69151760626145,1.27587913543918,"CD3E","CD3e molecule",TRUE
+"205264_at",0.983993333105312,0.921489284712541,-0.0996870140509173,-5.93484444934015,-0.0327076763688883,"CD3EAP","CD3e molecule associated protein",TRUE
+"206804_at",0.733934891101761,0.217999098715893,1.26789110392426,-5.18564195672562,0.41855751660861,"CD3G","CD3g molecule",TRUE
+"216424_at",0.526253358601247,0.0396402599283044,2.18628392403472,-3.84639336807518,0.930459406008706,"CD4","CD4 molecule",TRUE
+"203547_at",0.837368340567858,0.421143269811104,0.819654285155864,-5.61765121888337,0.546942806299234,"CD4","CD4 molecule",TRUE
+"215346_at",0.614730182193977,0.0855281663639612,1.7997834424153,-4.47426898740831,1.78985048970727,"CD40","CD40 molecule",TRUE
+"205153_s_at",0.634072872504683,0.104913823309497,1.69070767672632,-4.63577058972539,1.64205551771173,"CD40","CD40 molecule",TRUE
+"35150_at",0.662855903464759,0.130734487944159,1.56936669159202,-4.80639863152406,0.685534643242169,"CD40","CD40 molecule",TRUE
+"222292_at",0.937623890519979,0.72395252508566,0.357700338184623,-5.87755540531209,0.380118853597735,"CD40","CD40 molecule",TRUE
+"207892_at",0.859465912277024,0.476574106162487,0.724111595634506,-5.68747485450817,0.277559758076911,"CD40LG","CD40 ligand",TRUE
+"229221_at",0.270441084903894,0.00421653417089414,3.18883830726203,-1.92189394710831,3.07240280122557,"CD44","CD44 molecule (Indian blood group)",TRUE
+"234411_x_at",0.306787493213918,0.0061579037701838,3.02727879007939,-2.25268389991876,2.32640102519927,"CD44","CD44 molecule (Indian blood group)",TRUE
+"217523_at",0.315093142651413,0.00678264213954222,2.98569455414272,-2.33685007031887,3.4186657240484,"CD44","CD44 molecule (Indian blood group)",TRUE
+"209835_x_at",0.383328885347805,0.0122173419453815,2.72858233480357,-2.84682027099045,3.39093465899147,"CD44","CD44 molecule (Indian blood group)",TRUE
+"204490_s_at",0.422574093216884,0.0176565529277955,2.56362436846522,-3.16307326755697,3.33789677028669,"CD44","CD44 molecule (Indian blood group)",TRUE
+"1557905_s_at",0.429284714913652,0.0189412356574987,2.53173869131154,-3.22308210035937,3.25972583584292,"CD44","CD44 molecule (Indian blood group)",TRUE
+"216056_at",0.438807740024285,0.0201503029001179,2.50352387291686,-3.27586058068762,2.57122943390899,"CD44","CD44 molecule (Indian blood group)",TRUE
+"212014_x_at",0.442846733327149,0.020625031277583,2.49287535076132,-3.29569965046422,3.64566432825048,"CD44","CD44 molecule (Indian blood group)",TRUE
+"204489_s_at",0.459620665490213,0.0230251669460941,2.44230094517138,-3.38931146972812,2.70424215668907,"CD44","CD44 molecule (Indian blood group)",TRUE
+"1565868_at",0.465776708318531,0.0241428658687648,2.4204004784396,-3.42952800296924,1.41104620482047,"CD44","CD44 molecule (Indian blood group)",TRUE
+"210916_s_at",0.46584896273628,0.0242251790403311,2.41882498273233,-3.43241352622546,3.38400263957863,"CD44","CD44 molecule (Indian blood group)",TRUE
+"212063_at",0.540483367247649,0.0446692570198223,2.12834282612491,-3.9456015325535,2.99371422838963,"CD44","CD44 molecule (Indian blood group)",TRUE
+"234418_x_at",0.620912785033482,0.0905792050164408,1.76946845036654,-4.51990074819954,1.40764945711837,"CD44","CD44 molecule (Indian blood group)",TRUE
+"211574_s_at",0.957017346544368,0.805420932846916,-0.249305728698262,-5.90945613669158,-0.112260950955037,"CD46","CD46 molecule",TRUE
+"208783_s_at",0.966313390701604,0.842913747669009,-0.20050621895817,-5.92012115514215,-0.0939562834349079,"CD46","CD46 molecule",TRUE
+"207549_x_at",0.99783553534859,0.989235843294037,-0.0136443422768762,-5.93959280554993,-0.00537399949922168,"CD46","CD46 molecule",TRUE
+"213856_at",0.87617681287531,0.524744576819424,0.646267027064655,-5.73827827704109,0.702160307572187,"CD47","CD47 molecule",TRUE
+"242974_at",0.918041148686074,0.651906515824348,-0.457301762886025,-5.83833657092897,-0.329190333657185,"CD47","CD47 molecule",TRUE
+"226016_at",0.928203838544968,0.684434676813515,0.411810959390237,-5.85741915598586,0.22602099823513,"CD47","CD47 molecule",TRUE
+"213055_at",0.937113154905832,0.719652344973313,-0.363533079419955,-5.87551921228024,-0.136362289582943,"CD47","CD47 molecule",TRUE
+"213857_s_at",0.945272089973488,0.753001931535533,-0.318615733047905,-5.89035938331675,-0.173101889237897,"CD47","CD47 molecule",TRUE
+"211075_s_at",0.982646305191608,0.915806586691241,-0.106930299911637,-5.93411589162471,-0.0532693447715058,"CD47","CD47 molecule",TRUE
+"227259_at",0.984141840547367,0.922312353171415,-0.0986383759661293,-5.93494569662863,-0.030095905059266,"CD47","CD47 molecule",TRUE
+"204118_at",0.836457932702239,0.41812952462158,0.825064925221809,-5.61345393336302,0.263880778721742,"CD48","CD48 molecule",TRUE
+"237759_at",0.887083096014278,0.551515209148666,-0.604709429806269,-5.76312984443462,-0.450667130164581,"CD48","CD48 molecule",TRUE
+"230489_at",0.908253817129573,0.618908321258281,0.504474376369108,-5.81648308701085,0.296359575064396,"CD5","CD5 molecule",TRUE
+"206485_at",0.923494952314901,0.671738612864554,0.429456186795055,-5.85025021476566,0.27561271197674,"CD5","CD5 molecule",TRUE
+"34210_at",0.820288124919738,0.378669908079387,0.898327242778398,-5.55409026051542,0.64713020276888,"CD52","CD52 molecule",TRUE
+"204661_at",0.866425733191666,0.497445661765311,0.689858702580348,-5.71050855089898,0.5127549635717,"CD52","CD52 molecule",TRUE
+"237606_at",0.463701895754727,0.0238063323526935,-2.42689399864651,-3.41762428667641,-1.43864558241714,"CD53","CD53 molecule",TRUE
+"242946_at",0.747587302711183,0.239486717965425,-1.20878752996053,-5.25200899654394,-1.04223247492573,"CD53","CD53 molecule",TRUE
+"203416_at",0.859064198633089,0.475812758784024,0.725377368218009,-5.68660332600748,0.362909386113051,"CD53","CD53 molecule",TRUE
+"201925_s_at",0.904381089098038,0.607270720438607,0.521385923840267,-5.80813900480481,0.315121772188842,"CD55","CD55 molecule (Cromer blood group)",TRUE
+"201926_s_at",0.920169584950428,0.660345073945822,0.445409847890394,-5.843514299146,0.224296547896712,"CD55","CD55 molecule (Cromer blood group)",TRUE
+"1555950_a_at",0.951318915881544,0.777175739904805,0.28647530768247,-5.8997899961252,0.145075327478953,"CD55","CD55 molecule (Cromer blood group)",TRUE
+"216322_at",0.76858139690485,0.271739454694191,1.12714726510404,-5.33913732595205,0.517154678993597,"CD58","CD58 molecule",TRUE
+"222061_at",0.769258076576208,0.275601612766136,1.11785952520125,-5.34870964391227,0.926437512873785,"CD58","CD58 molecule",TRUE
+"205173_x_at",0.789503009592599,0.316490982759392,1.02485564184267,-5.44065925775732,0.586032966806783,"CD58","CD58 molecule",TRUE
+"211744_s_at",0.878278790222455,0.531125540421923,0.636259760449151,-5.74440788944385,0.368645211063846,"CD58","CD58 molecule",TRUE
+"216942_s_at",0.942684843065067,0.742850722782628,0.332213093442617,-5.88607099597802,0.197742901260973,"CD58","CD58 molecule",TRUE
+"200984_s_at",0.540483367247649,0.0449412474139847,2.12537999467997,-3.95062952479972,1.03027859894969,"CD59","CD59 molecule",TRUE
+"228748_at",0.597654932724127,0.0749404884551939,1.86871823805298,-4.36843094699785,1.86097876996564,"CD59","CD59 molecule",TRUE
+"212463_at",0.598618215299661,0.0755476873703514,1.86454277979418,-4.37492226071305,0.96244080797284,"CD59","CD59 molecule",TRUE
+"200983_x_at",0.618124814816155,0.0890380711303102,1.77856021865044,-4.50627473807756,0.864168473627071,"CD59","CD59 molecule",TRUE
+"200985_s_at",0.62986301194198,0.100986418584686,1.71132531837643,-4.60581900410812,0.857311199980362,"CD59","CD59 molecule",TRUE
+"206680_at",0.555307820043702,0.0514867859491656,2.05853811670477,-4.06286544101055,1.38866984783863,"CD5L","CD5 molecule like",TRUE
+"1566099_at",0.630603891142543,0.101756174492187,-1.70723128004054,-4.61178816403428,-0.971961281711226,"CD6","CD6 molecule",TRUE
+"213958_at",0.703463984269897,0.175161567112033,1.40067321289934,-5.02678865011785,0.909170094917084,"CD6","CD6 molecule",TRUE
+"208602_x_at",0.778397054392363,0.298236661209079,1.06524437365456,-5.40160601917506,0.46466229532121,"CD6","CD6 molecule",TRUE
+"1566447_at",0.91653541034501,0.647188894254177,0.463979188737851,-5.83537061707458,0.351258829760372,"CD6","CD6 molecule",TRUE
+"211900_x_at",0.942684843065067,0.743402331306316,0.331472603785339,-5.88630910013967,0.185512933262531,"CD6","CD6 molecule",TRUE
+"211893_x_at",0.984161165881616,0.92272920499179,0.098107325296197,-5.93499656220146,0.0559863869632311,"CD6","CD6 molecule",TRUE
+"1566448_at",0.989524702314661,0.948407771772621,0.0654435236550859,-5.93759767536863,0.0301603829314949,"CD6","CD6 molecule",TRUE
+"200663_at",0.522042520786155,0.0380412719791953,-2.20610619314069,-3.81207503395103,-0.651439870242887,"CD63","CD63 molecule",TRUE
+"209795_at",0.622434989367596,0.0929533032708578,1.75571947374714,-4.54040918220004,1.94193206659807,"CD69","CD69 molecule",TRUE
+"214551_s_at",0.695812999227098,0.165991874126654,1.43238519224739,-4.9869095125539,1.06136575553072,"CD7","CD7 molecule",TRUE
+"214049_x_at",0.784552021081681,0.308103030149755,-1.04320398672477,-5.42308591401505,-0.7098352621915,"CD7","CD7 molecule",TRUE
+"206508_at",0.484872899389517,0.0278907227906727,2.35324550106858,-3.55159625181893,1.16565199232272,"CD70","CD70 molecule",TRUE
+"215925_s_at",0.956619372543067,0.803061080625945,-0.252396765917925,-5.9087030928794,-0.167128056957773,"CD72","CD72 molecule",TRUE
+"209619_at",0.446963972064621,0.021118492354435,2.48204587797848,-3.31583030508896,3.21331082354512,"CD74","CD74 molecule",TRUE
+"1567627_at",0.893342502624307,0.567998981341774,-0.579649249552465,-5.77734537345315,-0.349953056699713,"CD74","CD74 molecule",TRUE
+"1567628_at",0.899808883319249,0.59213916531088,0.543608367949422,-5.79676739983606,0.25171459676907,"CD74","CD74 molecule",TRUE
+"1555779_a_at",0.609886795316146,0.0819799273380436,1.82201729308599,-4.44044436916159,0.443711637873116,"CD79A","CD79a molecule",TRUE
+"205049_s_at",0.990623482682449,0.952487954428545,-0.0602610741602245,-5.93791491590182,-0.0326963320566929,"CD79A","CD79a molecule",TRUE
+"1555748_x_at",0.948429371744093,0.765255701438928,0.302283024056223,-5.89527580972838,0.18131420995759,"CD79B","CD79b molecule",TRUE
+"205297_s_at",0.982573681110724,0.915532492848315,0.107279810669658,-5.93407944597484,0.0484632160449578,"CD79B","CD79b molecule",TRUE
+"1555746_at",0.989669132517581,0.950481982399584,0.0628087418539444,-5.93776222952231,0.0475175066210198,"CD79B","CD79b molecule",TRUE
+"1555689_at",0.523369751179323,0.0388953479064403,2.19542636054347,-3.83058865707447,1.8138406174122,"CD80","CD80 molecule",TRUE
+"1554519_at",0.820100019970498,0.378078483829472,-0.89946217388933,-5.55313380879683,-0.427882902660124,"CD80","CD80 molecule",TRUE
+"207176_s_at",0.973071267819624,0.87060575328818,-0.164787050687567,-5.92646604074935,-0.0427783115776075,"CD80","CD80 molecule",TRUE
+"200675_at",0.571677937624457,0.0595633428239204,-1.9858264152552,-4.18227885882195,-0.56199502159596,"CD81","CD81 molecule",TRUE
+"1561726_s_at",0.843095426822889,0.437367840394598,0.790933353573565,-5.63949725561853,0.420465155261013,"CD81-AS1","CD81 antisense RNA 1",TRUE
+"203904_x_at",0.861665593344139,0.483659199976127,0.712388521613369,-5.69547779203264,0.717614589727047,"CD82","CD82 molecule",TRUE
+"228910_at",0.922253982025599,0.668257107203317,0.434318921964375,-5.84822263795027,0.393141874268466,"CD82","CD82 molecule",TRUE
+"204440_at",0.129921283795816,0.000786537630295657,3.8866911130591,-0.444798568741795,1.82059634958439,"CD83","CD83 molecule",TRUE
+"244352_at",0.587947964200177,0.0669130999592755,1.92689822126469,-4.27692578179094,0.87770941019647,"CD84","CD84 molecule",TRUE
+"211190_x_at",0.623841549898917,0.0954217931671923,1.74173958029423,-4.56114104058262,0.904958344233272,"CD84","CD84 molecule",TRUE
+"211188_at",0.739189560382301,0.226343218639565,-1.24443442566327,-5.21230756325216,-0.586238767376239,"CD84","CD84 molecule",TRUE
+"205988_at",0.774230543658252,0.290211914809324,1.08355766912195,-5.38345271430041,0.314973126151124,"CD84","CD84 molecule",TRUE
+"211189_x_at",0.819780516863333,0.377303565783667,0.900950996372736,-5.55187742577393,0.26497086504352,"CD84","CD84 molecule",TRUE
+"211191_at",0.877546037473893,0.528011527597873,0.641135236297247,-5.74143306545123,0.206151790565201,"CD84","CD84 molecule",TRUE
+"230391_at",0.936992192746977,0.718778748918757,0.364719585755823,-5.87510102601951,0.267464852484419,"CD84","CD84 molecule",TRUE
+"211192_s_at",0.94632739401154,0.757456616966282,0.312668208735174,-5.89217935623216,0.231776569806648,"CD84","CD84 molecule",TRUE
+"210895_s_at",0.538039282264231,0.0437346848626634,2.13864871411293,-3.92807772914734,1.49493828563546,"CD86","CD86 molecule",TRUE
+"205686_s_at",0.740610299769501,0.230693571382071,1.23246576988054,-5.22574859392685,0.968217609421418,"CD86","CD86 molecule",TRUE
+"205685_at",0.975398143273847,0.882099661144877,0.150028279430072,-5.92872637056922,0.121821498448274,"CD86","CD86 molecule",TRUE
+"205758_at",0.948814396904806,0.767067019318592,-0.299875980962514,-5.89597869816767,-0.233921921758741,"CD8A","CD8a molecule",TRUE
+"230037_at",0.816358096928248,0.367434399748405,0.920091604315742,-5.53555430469069,0.237556272969465,"CD8B","CD8b molecule",TRUE
+"233322_at",0.812302873476553,0.356715574867149,0.941272098944212,-5.51712350224267,0.245575555986596,"CD9","CD9 molecule",TRUE
+"201005_at",0.936992192746977,0.718199183316782,-0.365507038238883,-5.87482274431272,-0.182224489096383,"CD9","CD9 molecule",TRUE
+"233317_at",0.940227139261806,0.732805441329273,0.345731734666641,-5.88163171794594,0.283508828655014,"CD9","CD9 molecule",TRUE
+"202877_s_at",0.848364007856994,0.448235507434738,0.772060975742764,-5.65345277373927,0.438176098552368,"CD93","CD93 molecule",TRUE
+"202878_s_at",0.965584868976477,0.83906129058082,-0.205495528517648,-5.91913648308582,-0.0983733526912731,"CD93","CD93 molecule",TRUE
+"206761_at",0.766550448794594,0.267409620413271,1.13767527526623,-5.32820214469191,0.866646254085705,"CD96","CD96 molecule",TRUE
+"1555120_at",0.962808206628386,0.830950575219383,0.216017332081398,-5.91698093962719,0.220641623118486,"CD96","CD96 molecule",TRUE
+"201029_s_at",0.723649742218726,0.200356158406804,-1.31986206932218,-5.12505215002237,-0.57783062207813,"CD99","CD99 molecule",TRUE
+"201028_s_at",0.734042693548791,0.218302647255708,-1.26702582463832,-5.18663318224786,-0.635179008979378,"CD99","CD99 molecule",TRUE
+"233825_s_at",0.616045154979875,0.087130812683299,-1.79000137859782,-4.4890551965825,-1.01401722398511,"CD99L2","CD99 molecule like 2",TRUE
+"233844_at",0.767704684098492,0.269513338743028,-1.13254458518768,-5.33354247497827,-0.346644282294469,"CD99L2","CD99 molecule like 2",TRUE
+"223041_at",0.856604109038346,0.47054865680581,-0.734161883696045,-5.68051504667737,-0.296543857757886,"CD99L2","CD99 molecule like 2",TRUE
+"1554758_a_at",0.911730272337063,0.630915680912168,0.48718032600127,-5.82473816938867,0.280974200945306,"CD99L2","CD99 molecule like 2",TRUE
+"232172_at",0.830635993561085,0.403825514308722,0.851087267993836,-5.59290666776927,0.424470459053108,"CD99P1","CD99 molecule pseudogene 1",TRUE
+"239247_at",0.94149227422279,0.738338251939851,0.3382778810799,-5.88410108506068,0.382084365924624,"CD99P1","CD99 molecule pseudogene 1",TRUE
+"205627_at",0.071020853517731,0.000202269085380847,4.44136707029361,0.752605876035304,6.61542612697518,"CDA","cytidine deaminase",TRUE
+"233564_s_at",0.818226240461037,0.371198603902983,-0.912751445281892,-5.54185142054651,-0.272667784069401,"CDADC1","cytidine and dCMP deaminase domain containing 1",TRUE
+"223527_s_at",0.828941412891522,0.399873972298679,-0.858379348604668,-5.58704209383844,-0.240893613789696,"CDADC1","cytidine and dCMP deaminase domain containing 1",TRUE
+"233647_s_at",0.861659105448003,0.482414498277017,-0.71444074462456,-5.69408578539732,-0.246626621095569,"CDADC1","cytidine and dCMP deaminase domain containing 1",TRUE
+"221015_s_at",0.999886947266554,0.99972754219371,-0.000345348659892857,-5.93968342265919,-0.000218007178450996,"CDADC1","cytidine and dCMP deaminase domain containing 1",TRUE
+"231080_at",0.64513208805899,0.11614208853389,1.63516991758921,-4.71507946958818,1.20847189396444,"CDAN1","codanin 1",TRUE
+"228516_at",0.813442508625161,0.363467090939186,-0.927882221526625,-5.52881993075787,-0.353859751686642,"CDAN1","codanin 1",TRUE
+"201725_at",0.7083523771159,0.180260906310199,1.38360763310731,-5.04794436037705,0.419064716847993,"CDC123","cell division cycle 123",TRUE
+"210742_at",0.662855903464759,0.130827286023408,1.56896823429399,-4.80694267651165,1.20952037261619,"CDC14A","cell division cycle 14A",TRUE
+"205288_at",0.847692162683017,0.446676016587064,-0.774751839943716,-5.65148239388427,-0.3990501381269,"CDC14A","cell division cycle 14A",TRUE
+"210441_at",0.848432085400071,0.448633196543236,-0.771375682914224,-5.65395354419494,-0.426891377025627,"CDC14A","cell division cycle 14A",TRUE
+"210440_s_at",0.940227139261806,0.7329753150021,0.345502584089742,-5.88170842536911,0.176906720458407,"CDC14A","cell division cycle 14A",TRUE
+"210743_s_at",0.968980656821882,0.853624550827302,-0.186661580067289,-5.92272719646627,-0.0799043966269419,"CDC14A","cell division cycle 14A",TRUE
+"234605_at",0.657015752622694,0.126045904330575,1.58981094836004,-4.77833941398629,1.29842223304394,"CDC14B","cell division cycle 14B",TRUE
+"211348_s_at",0.682539393883246,0.150283156663301,1.4901523265325,-4.91239863704758,1.31164913881202,"CDC14B","cell division cycle 14B",TRUE
+"208022_s_at",0.687277721925286,0.155927077633609,1.46885771501104,-4.94014323693673,1.61611510722667,"CDC14B","cell division cycle 14B",TRUE
+"221555_x_at",0.69794616906853,0.16896233184803,1.42196192229302,-5.00009808347919,0.631104443070507,"CDC14B","cell division cycle 14B",TRUE
+"230887_at",0.744307803443383,0.235274959145192,1.22004540492422,-5.23957837038971,0.582918495376726,"CDC14B","cell division cycle 14B",TRUE
+"221556_at",0.75235436509186,0.245720930908923,1.19239433329546,-5.26993094842934,1.42344627932808,"CDC14B","cell division cycle 14B",TRUE
+"211347_at",0.829459856894727,0.4007175346452,0.856818790800304,-5.58830107479077,0.786425884813308,"CDC14B","cell division cycle 14B",TRUE
+"234740_at",0.93527815307551,0.712203848406041,0.373666803397848,-5.87190425479084,0.278226822900304,"CDC14B","cell division cycle 14B",TRUE
+"1553320_s_at",0.895690630367785,0.575684011766968,-0.568093556797213,-5.78370423201174,-0.593985572202163,"CDC14C","cell division cycle 14C, pseuodgene",TRUE
+"202717_s_at",0.571677937624457,0.0595063738767699,1.98630775500296,-4.18149779733395,0.790150966217835,"CDC16","cell division cycle 16",TRUE
+"209659_s_at",0.64484773720849,0.115301943859839,1.6391650674468,-4.70944189204591,0.667182137144868,"CDC16","cell division cycle 16",TRUE
+"209658_at",0.711427723123186,0.185060890073877,1.36789059598349,-5.06723791344572,0.710689746126521,"CDC16","cell division cycle 16",TRUE
+"202870_s_at",0.901154557823402,0.597588674952045,0.535573770643577,-5.80093212576182,0.271208027076703,"CDC20","cell division cycle 20",TRUE
+"240161_s_at",0.55937703282623,0.0530217444071785,-2.04397182981442,-4.08701471338594,-1.99382289679969,"CDC20B","cell division cycle 20B",TRUE
+"1555346_at",0.681231910132377,0.149100546688703,1.49469659334617,-4.90643631907526,1.27354376656085,"CDC20B","cell division cycle 20B",TRUE
+"241120_s_at",0.788413816943444,0.31457849549001,1.02900874242464,-5.43670619971741,0.664725639692342,"CDC20B","cell division cycle 20B",TRUE
+"1553655_at",0.799008022536007,0.333590102769344,0.988480066409308,-5.47466367319521,0.44936925493012,"CDC20B","cell division cycle 20B",TRUE
+"1564674_a_at",0.97304633500821,0.868995198672265,-0.166858005310049,-5.92613195796764,-0.056217854819228,"CDC20B","cell division cycle 20B",TRUE
+"223651_x_at",0.597654932724127,0.074073264498085,-1.87473326711558,-4.35906175001179,-0.630734150435879,"CDC23","cell division cycle 23",TRUE
+"202892_at",0.805991582894782,0.34631208981489,-0.962243390089535,-5.49849585084991,-0.274747606678281,"CDC23","cell division cycle 23",TRUE
+"1555772_a_at",0.837609393049242,0.421841875879962,-0.818403535974619,-5.61861780144517,-0.381029727552936,"CDC25A","cell division cycle 25A",TRUE
+"204695_at",0.94895689004559,0.769057140387395,-0.297233410916891,-5.89674394814232,-0.192894090075193,"CDC25A","cell division cycle 25A",TRUE
+"204696_s_at",0.958792863216689,0.813408028693519,0.238862085343558,-5.91193219196868,0.0977569787657258,"CDC25A","cell division cycle 25A",TRUE
+"201853_s_at",0.992179245947777,0.963587398568454,0.0461712313557831,-5.93864522137973,0.0210524544318851,"CDC25B","cell division cycle 25B",TRUE
+"216914_at",0.837642003916702,0.422122544744708,-0.817901406148112,-5.61900545964526,-0.563637943445805,"CDC25C","cell division cycle 25C",TRUE
+"217010_s_at",0.943464796017993,0.74643245096819,0.32740827066886,-5.88760662218947,0.132680776984497,"CDC25C","cell division cycle 25C",TRUE
+"205167_s_at",0.961212424803935,0.822956753140496,0.226411950759298,-5.91474626743511,0.0870584618252934,"CDC25C","cell division cycle 25C",TRUE
+"225422_at",0.888830748858811,0.555869285946609,-0.598052559033122,-5.76696269494488,-0.201288500624029,"CDC26","cell division cycle 26",TRUE
+"217878_s_at",0.736559969329597,0.222071692035275,-1.2563581191809,-5.19880603121841,-0.414434398950707,"CDC27","cell division cycle 27",TRUE
+"217881_s_at",0.764077045023402,0.264100854351164,-1.14580527831277,-5.31969639325817,-0.517273752200911,"CDC27","cell division cycle 27",TRUE
+"217879_at",0.85334340854827,0.460963332039632,-0.750307941725255,-5.66914342280353,-0.242888794876013,"CDC27","cell division cycle 27",TRUE
+"217880_at",0.965380895563592,0.838485677062128,0.206241459727988,-5.91898719761246,0.0763112620822497,"CDC27","cell division cycle 27",TRUE
+"241927_x_at",0.554642754132296,0.0511115543146261,2.06215793616475,-4.05684679008513,0.729828640007957,"CDC34","cell division cycle 34",TRUE
+"212540_at",0.868608636812693,0.50472238484754,-0.678110692926408,-5.71816325040818,-0.283985159060336,"CDC34","cell division cycle 34",TRUE
+"209953_s_at",0.679041081350052,0.146496503044093,1.50480745232495,-4.89311808035526,0.556609878637047,"CDC37","cell division cycle 37",TRUE
+"219343_at",0.896159990898752,0.578904338525915,-0.563274498218258,-5.78631938994767,-0.308137678747322,"CDC37L1","cell division cycle 37 like 1",TRUE
+"235787_at",0.961475152596758,0.825310167629853,-0.223349133727365,-5.91541558262594,-0.14258716509064,"CDC37L1","cell division cycle 37 like 1",TRUE
+"228561_at",0.976422537443518,0.888044077476992,-0.142408918012892,-5.92981051915222,-0.0666770632041729,"CDC37L1","cell division cycle 37 like 1",TRUE
+"203377_s_at",0.867834927246481,0.500904487638776,0.684262500334984,-5.71417056399621,0.225843099399411,"CDC40","cell division cycle 40",TRUE
+"203376_at",0.98273450122649,0.916112303566363,-0.106540481139134,-5.93415640029876,-0.0284449790676309,"CDC40","cell division cycle 40",TRUE
+"208728_s_at",0.736462193466674,0.221996038601267,-1.25657087515726,-5.19856411855039,-0.30518039986975,"CDC42","cell division cycle 42",TRUE
+"226400_at",0.897024165042344,0.582815589731343,0.557439563742017,-5.78945690957151,0.309936102741981,"CDC42","cell division cycle 42",TRUE
+"208727_s_at",0.904381089098038,0.607921346575759,-0.520436417436663,-5.80861459099731,-0.213229440766115,"CDC42","cell division cycle 42",TRUE
+"210232_at",0.982844899319041,0.916577271351577,0.105947634353748,-5.93421772368687,0.0371481298674778,"CDC42","cell division cycle 42",TRUE
+"214230_at",0.987257510450304,0.940497386930509,0.0754962745421713,-5.93690775438714,0.0396785374353419,"CDC42","cell division cycle 42",TRUE
+"1556931_at",0.90344422113846,0.604185934255921,0.525894410351147,-5.80586928467224,0.210238665212102,"CDC42-IT1","CDC42 intronic transcript 1",TRUE
+"240735_at",0.552420073963858,0.0498251721373014,2.07475069360991,-4.03585527769444,1.36539529880255,"CDC42BPA","CDC42 binding protein kinase alpha",TRUE
+"213595_s_at",0.55937703282623,0.0535483270638528,-2.03906139180961,-4.09513027917588,-1.02843327739458,"CDC42BPA","CDC42 binding protein kinase alpha",TRUE
+"215296_at",0.61760967235709,0.08793122382792,1.78517389545756,-4.49633063022912,1.40921277541762,"CDC42BPA","CDC42 binding protein kinase alpha",TRUE
+"203794_at",0.827011327018402,0.395398349525767,-0.866694722484583,-5.58029771727147,-0.46095895162323,"CDC42BPA","CDC42 binding protein kinase alpha",TRUE
+"214464_at",0.959236876269244,0.815408363939015,-0.236250811067445,-5.91253482738462,-0.153924861163308,"CDC42BPA","CDC42 binding protein kinase alpha",TRUE
+"217849_s_at",0.673190784310977,0.138802828521405,-1.53556500956232,-4.85216315985925,-0.641943701987341,"CDC42BPB","CDC42 binding protein kinase beta",TRUE
+"1557963_at",0.93474377881867,0.710175994927911,0.376432581148781,-5.87090059706976,0.266010802515806,"CDC42BPB","CDC42 binding protein kinase beta",TRUE
+"1569044_at",0.824027323790285,0.391342668118788,0.874282541903806,-5.57409070130404,0.364083699897701,"CDC42BPG","CDC42 binding protein kinase gamma",TRUE
+"1564823_at",0.863993702749895,0.490600205447008,-0.701000062168716,-5.70313316350755,-0.33232156405017,"CDC42BPG","CDC42 binding protein kinase gamma",TRUE
+"204693_at",0.709431919391341,0.182459166952621,1.37636901938492,-5.05685292172686,1.00613749747659,"CDC42EP1","CDC42 effector protein 1",TRUE
+"214014_at",0.904440331740253,0.608303325451931,-0.519879193344613,-5.80889329865904,-0.456896502600394,"CDC42EP2","CDC42 effector protein 2",TRUE
+"209850_s_at",0.941952420964607,0.739249023363397,0.337052763776966,-5.8845018580499,0.178484206974503,"CDC42EP2","CDC42 effector protein 2",TRUE
+"209287_s_at",0.580630437263151,0.0629447365446631,1.95796159903998,-4.22727598133493,1.81755797297703,"CDC42EP3","CDC42 effector protein 3",TRUE
+"209288_s_at",0.626839388794963,0.0973707714501257,1.73091884932115,-4.57710360632681,2.31743702013026,"CDC42EP3","CDC42 effector protein 3",TRUE
+"209286_at",0.65523332696065,0.1238921286533,1.5994150528614,-4.76506023187009,1.88939901806284,"CDC42EP3","CDC42 effector protein 3",TRUE
+"225685_at",0.666643938027574,0.133450195996307,1.55780161157577,-4.82214516160474,2.26585272930888,"CDC42EP3","CDC42 effector protein 3",TRUE
+"214721_x_at",0.643082025527735,0.113640104350887,-1.64714023813311,-4.69815654412118,-0.598169199103104,"CDC42EP4","CDC42 effector protein 4",TRUE
+"218062_x_at",0.733012446828677,0.217468466759929,-1.26940592083395,-5.18390525702044,-0.504100554671721,"CDC42EP4","CDC42 effector protein 4",TRUE
+"218063_s_at",0.897560972979555,0.584600709808412,-0.55478296164729,-5.79087489546875,-0.484955261515037,"CDC42EP4","CDC42 effector protein 4",TRUE
+"227850_x_at",0.951089759647433,0.776562396894023,-0.28728683903918,-5.89956410317223,-0.4516847164082,"CDC42EP5","CDC42 effector protein 5",TRUE
+"218157_x_at",0.466300647363886,0.0243781223682896,-2.41591072189962,-3.43774829041171,-0.982337930549072,"CDC42SE1","CDC42 small effector 1",TRUE
+"222537_s_at",0.643688366500038,0.114535256301499,-1.6428323092808,-4.70425773684319,-1.03131849671099,"CDC42SE1","CDC42 small effector 1",TRUE
+"229120_s_at",0.700061364939874,0.171405095399403,-1.41349985755187,-5.01074699717408,-0.444287510861328,"CDC42SE1","CDC42 small effector 1",TRUE
+"223674_s_at",0.771011793494937,0.279728710237969,-1.10803896405532,-5.35875477584797,-0.577383594525307,"CDC42SE1","CDC42 small effector 1",TRUE
+"239023_at",0.965580083724105,0.838896425343708,-0.205709163352777,-5.91909378274814,-0.0929615126693983,"CDC42SE1","CDC42 small effector 1",TRUE
+"1552613_s_at",0.769782310234542,0.277316637850087,-1.11376565588485,-5.35290667965779,-0.444974665342674,"CDC42SE2","CDC42 small effector 2",TRUE
+"1552612_at",0.843950128127185,0.44018154190769,-0.786019911527569,-5.64316116481477,-0.273403157406225,"CDC42SE2","CDC42 small effector 2",TRUE
+"224709_s_at",0.922389916958654,0.668427938758653,-0.434080068320685,-5.84832275446721,-0.126752845092474,"CDC42SE2","CDC42 small effector 2",TRUE
+"229026_at",0.986145735582101,0.932295105202556,0.0859284159341338,-5.93608779608522,0.0519877603766918,"CDC42SE2","CDC42 small effector 2",TRUE
+"204126_s_at",0.965615736227539,0.839251207782947,0.205249443097393,-5.91918561472928,0.0832443032327621,"CDC45","cell division cycle 45",TRUE
+"209055_s_at",0.84772210282622,0.446980426323982,0.774226140232972,-5.6518678449261,0.262665605366282,"CDC5L","cell division cycle 5 like",TRUE
+"209056_s_at",0.896907177224677,0.582036355614776,0.558600485440546,-5.78883519289842,0.182926333816484,"CDC5L","cell division cycle 5 like",TRUE
+"209057_x_at",0.961212424803935,0.82357863872477,-0.22560239272574,-5.91492406155388,-0.0560089081431823,"CDC5L","cell division cycle 5 like",TRUE
+"222179_at",0.992342196993659,0.963919697700132,-0.0457495668042433,-5.93866409789913,-0.0220795282660573,"CDC5L","cell division cycle 5 like",TRUE
+"203968_s_at",0.616413638398853,0.0873024668723806,1.78896287793762,-4.49062151478306,0.766542943534542,"CDC6","cell division cycle 6",TRUE
+"203967_at",0.726696341943087,0.206835201758035,1.30037936384083,-5.14800785152333,0.560268318147875,"CDC6","cell division cycle 6",TRUE
+"204510_at",0.851511864681585,0.455556900846841,-0.759503286429348,-5.66256247769575,-0.27713402960835,"CDC7","cell division cycle 7",TRUE
+"218578_at",0.411110107932987,0.016208936290889,-2.60226790871924,-3.08984227486685,-0.898769237081739,"CDC73","cell division cycle 73",TRUE
+"235196_at",0.531311912163363,0.0416983889363144,-2.1618103133413,-3.88850054284562,-0.88357370516986,"CDC73","cell division cycle 73",TRUE
+"229828_at",0.597346378847428,0.0732829966865633,-1.88026832484939,-4.35042142850848,-0.833588089843404,"CDC73","cell division cycle 73",TRUE
+"226661_at",0.702809964629668,0.17453547498911,-1.40279568162457,-5.02414250624197,-1.14355873628106,"CDCA2","cell division cycle associated 2",TRUE
+"236957_at",0.939976205834042,0.730160894625236,-0.349301531595543,-5.88043024840706,-0.153500180391623,"CDCA2","cell division cycle associated 2",TRUE
+"221436_s_at",0.862634144901168,0.485959816330218,0.70860338577558,-5.69803521718385,0.289472196362627,"CDCA3","cell division cycle associated 3",TRUE
+"223307_at",0.867436259435403,0.499805111677979,0.686038849250912,-5.71301125357704,0.265327355868457,"CDCA3","cell division cycle associated 3",TRUE
+"218399_s_at",0.895999830738594,0.576979644090433,-0.566153079575163,-5.78475986822803,-0.225477875256884,"CDCA4","cell division cycle associated 4",TRUE
+"224753_at",0.861113073516266,0.481327749452954,-0.716235056884376,-5.69286559471892,-0.323126591941421,"CDCA5","cell division cycle associated 5",TRUE
+"230060_at",0.782206338814045,0.304067654839506,1.05215709923058,-5.41440910921936,0.65248184198891,"CDCA7","cell division cycle associated 7",TRUE
+"224428_s_at",0.93541228001674,0.712709734996568,0.372977290843209,-5.87215333102793,0.430015386265028,"CDCA7","cell division cycle associated 7",TRUE
+"225081_s_at",0.760244814241272,0.258596315896275,1.15949856856717,-5.30524985865119,1.56668490380569,"CDCA7L","cell division cycle associated 7 like",TRUE
+"221520_s_at",0.955892698633978,0.799876339277394,-0.256572272905676,-5.9076712063127,-0.0797833594781867,"CDCA8","cell division cycle associated 8",TRUE
+"234932_s_at",0.426884347674613,0.0183510768882164,2.54612691002264,-3.19605072001755,2.39910783724499,"CDCP1","CUB domain containing protein 1",TRUE
+"218451_at",0.488294327273387,0.0289588154530598,2.33563247904584,-3.58329123052446,2.31020521880811,"CDCP1","CUB domain containing protein 1",TRUE
+"1554110_at",0.59507179340408,0.0719944145535061,1.88940650022839,-4.33611741499958,1.38675910902674,"CDCP1","CUB domain containing protein 1",TRUE
+"201131_s_at",0.909748582642183,0.624639974962108,0.496200018543578,-5.82046782176366,0.640182146038319,"CDH1","cadherin 1",TRUE
+"201130_s_at",0.931528703027792,0.697338991643238,0.394011528121924,-5.8643509019726,0.46901250102187,"CDH1","cadherin 1",TRUE
+"220115_s_at",0.973669917754054,0.87321796486963,-0.161429664969129,-5.92699880621114,-0.188262132324332,"CDH10","cadherin 10",TRUE
+"207172_s_at",0.758189649141895,0.255037750053778,-1.16846623814195,-5.29570731266322,-1.09498380120396,"CDH11","cadherin 11",TRUE
+"239286_at",0.870513303883422,0.509284116164957,0.670794608989866,-5.72286667170767,0.373673352972147,"CDH11","cadherin 11",TRUE
+"207173_x_at",0.898609426925686,0.58815781979052,-0.549501283029263,-5.79367450427363,-0.589405412034869,"CDH11","cadherin 11",TRUE
+"236179_at",0.968355922006275,0.851373921734644,-0.189567523815711,-5.92219559690388,-0.235608927198153,"CDH11","cadherin 11",TRUE
+"207149_at",0.628084912651991,0.0995063746005092,1.71927233860956,-4.59420162005317,1.67300457770048,"CDH12","cadherin 12",TRUE
+"204726_at",0.71399486949378,0.189079044806427,1.35497958328294,-5.08294949375529,1.1812068279641,"CDH13","cadherin 13",TRUE
+"206328_at",0.637485146909712,0.108572670210618,1.67208080706095,-4.66259448469786,0.998322236599825,"CDH15","cadherin 15",TRUE
+"206327_s_at",0.818637718131529,0.372173071284485,0.910859302768723,-5.54346714680571,0.480703871426922,"CDH15","cadherin 15",TRUE
+"206517_at",0.909441642299191,0.623932967041576,0.497218764604647,-5.81998069060337,0.26757957471174,"CDH16","cadherin 16",TRUE
+"209847_at",0.593339168375633,0.0703585076261748,1.90121627509771,-4.31755963380295,1.6657460185278,"CDH17","cadherin 17",TRUE
+"206280_at",0.183534093706442,0.00177153277096515,3.55208560762298,-1.16047197118551,3.37189326228739,"CDH18","cadherin 18",TRUE
+"206898_at",0.499435312830389,0.0315875137040235,2.29470427728299,-3.65641263631118,2.49397459711991,"CDH19","cadherin 19",TRUE
+"1555403_a_at",0.571825234520934,0.0598128672377727,1.98372293898943,-4.18569063510839,2.39042139312769,"CDH19","cadherin 19",TRUE
+"235639_at",0.627092759817312,0.0988780596849423,1.72267653427548,-4.58921288657924,1.4059540681207,"CDH19","cadherin 19",TRUE
+"203440_at",0.412728274083545,0.0165846185306182,2.59193753845484,-3.1094719259931,4.52699229532037,"CDH2","cadherin 2",TRUE
+"203441_s_at",0.492341486607851,0.0295942189488297,2.32543593905429,-3.6015778673185,2.14635067510542,"CDH2","cadherin 2",TRUE
+"210913_at",0.980067566136987,0.906437201339618,-0.118885713951357,-5.93280176538969,-0.065221443941128,"CDH20","cadherin 20",TRUE
+"215181_at",0.821903997044289,0.385013821573672,0.886225952644968,-5.5642189949614,0.644363463883877,"CDH22","cadherin 22",TRUE
+"1569679_at",0.843753336849204,0.439259980126338,0.787627064537745,-5.64196509150142,0.226763199175622,"CDH22","cadherin 22",TRUE
+"1553166_at",0.867159108376357,0.499084796517316,0.687203921670886,-5.71224932506554,0.261477001652248,"CDH24","cadherin 24",TRUE
+"230157_at",0.885199632879984,0.546311393308009,0.612701789151742,-5.75847396670943,0.23121157290702,"CDH24","cadherin 24",TRUE
+"233662_at",0.642592458809121,0.112868069706648,-1.65087865920323,-4.69285202042335,-1.83017458134303,"CDH26","cadherin 26",TRUE
+"233391_at",0.841206569659492,0.431227027607064,0.80172482384151,-5.63137476836384,0.203689901143516,"CDH26","cadherin 26",TRUE
+"232306_at",0.956398858120188,0.802245558830666,-0.25346555491498,-5.90844056693794,-0.247573360586015,"CDH26","cadherin 26",TRUE
+"233663_s_at",0.972022150098794,0.86587345430309,0.170874281503949,-5.92547219980118,0.123864855598236,"CDH26","cadherin 26",TRUE
+"203256_at",0.535243600695458,0.0427768694935327,2.14941915261785,-3.90970707510735,3.77148580806555,"CDH3","cadherin 3",TRUE
+"239485_at",0.789661545166663,0.317363651741316,1.02296642838764,-5.44245269613615,0.743266117412615,"CDH4","cadherin 4",TRUE
+"1563587_at",0.94943075115007,0.771682001697704,0.29375130289519,-5.89774206022397,0.150508556222285,"CDH4","cadherin 4",TRUE
+"220227_at",0.966111788889917,0.842311249754619,-0.201286166122372,-5.91996881721734,-0.0899053691733389,"CDH4","cadherin 4",TRUE
+"206866_at",0.977063818674184,0.890601255377214,0.139133890367292,-5.93025919218769,0.145719170415919,"CDH4","cadherin 4",TRUE
+"204677_at",0.782096995485383,0.303795396301541,1.05276417399393,-5.41381835809779,1.38752199168201,"CDH5","cadherin 5",TRUE
+"210601_at",0.606900628956089,0.080549379258879,-1.83121773737007,-4.42636020017436,-1.01197796863887,"CDH6","cadherin 6",TRUE
+"210602_s_at",0.783598827774051,0.306168602061255,1.04748538491444,-5.41894496257656,0.520468983997341,"CDH6","cadherin 6",TRUE
+"205533_s_at",0.819193107051406,0.375693095955798,0.9040515936216,-5.54925473915525,0.872441734024103,"CDH6","cadherin 6",TRUE
+"232631_at",0.902424542997102,0.601378197728568,-0.530007594397257,-5.80378197652179,-0.312120872332424,"CDH6","cadherin 6",TRUE
+"205532_s_at",0.925060113770489,0.675382709126482,-0.424377603459954,-5.85234384792252,-0.323319557128286,"CDH6","cadherin 6",TRUE
+"214803_at",0.940668681806864,0.734540598880072,0.343391984600207,-5.88241257754759,0.258790156291976,"CDH6","cadherin 6",TRUE
+"220679_s_at",0.822850703882235,0.388581231597694,-0.879478174284197,-5.56981157394532,-0.827787469718881,"CDH7","cadherin 7",TRUE
+"1554700_at",0.885029460971826,0.545503316901841,0.613946488588337,-5.75774357165579,0.714164976817879,"CDH7","cadherin 7",TRUE
+"217574_at",0.545412722791443,0.0470993779824495,2.10242709797926,-3.98942999129748,1.1349201291701,"CDH8","cadherin 8",TRUE
+"231438_x_at",0.808257777979515,0.350430963204634,-0.953890224024588,-5.50596055067458,-0.845877098390606,"CDH8","cadherin 8",TRUE
+"210518_at",0.95852392877631,0.812032370498215,0.240658879479531,-5.91151369789474,0.086818651247432,"CDH8","cadherin 8",TRUE
+"241500_at",0.986280597793838,0.932710809648075,-0.0853994736067583,-5.93613191939225,-0.0791527244059456,"CDH8","cadherin 8",TRUE
+"207729_at",0.720018659171833,0.196021540773164,-1.33317242363874,-5.10920356879602,-0.939607500935753,"CDH9","cadherin 9",TRUE
+"213369_at",0.912722788750542,0.634102792729991,-0.482615373719925,-5.82687025303574,-0.356173975200402,"CDHR1","cadherin related family member 1",TRUE
+"1555019_at",0.919959462096257,0.659409443430312,0.446725128895688,-5.8429482074843,0.165436798716943,"CDHR1","cadherin related family member 1",TRUE
+"220186_s_at",0.647186738248178,0.118085686342274,1.62601966224837,-4.7279515700972,0.557273697811353,"CDHR2","cadherin related family member 2",TRUE
+"231582_at",0.761748280722165,0.261154758223068,-1.15310757584042,-5.31201117593453,-0.729277972174914,"CDHR3","cadherin related family member 3",TRUE
+"235650_at",0.990712448117538,0.952972588042802,-0.0596456313154098,-5.93795085285194,-0.0341342005375669,"CDHR3","cadherin related family member 3",TRUE
+"220075_s_at",0.877740599174557,0.528533822858686,0.640316411978571,-5.74193420506349,0.20186233403346,"CDHR5","cadherin related family member 5",TRUE
+"219796_s_at",0.972659629123427,0.867819696529214,0.168370012690076,-5.92588541550816,0.0785649825549073,"CDHR5","cadherin related family member 5",TRUE
+"220074_at",0.994508616297087,0.974645728158149,0.0321431034039239,-5.93918026983338,0.0109393803281277,"CDHR5","cadherin related family member 5",TRUE
+"218183_at",0.79484155322319,0.327016747843913,1.00230695096962,-5.46186935991668,0.833932953450305,"CDIP1","cell death inducing p53 target 1",TRUE
+"223960_s_at",0.904381089098038,0.607207089625198,0.521478810994,-5.80809243439365,0.415507425057203,"CDIP1","cell death inducing p53 target 1",TRUE
+"201253_s_at",0.548598769328316,0.0484231853823219,-2.08881124559193,-4.01231921338856,-0.831539084484199,"CDIPT","CDP-diacylglycerol--inositol 3-phosphatidyltransferase",TRUE
+"240537_s_at",0.796630089799502,0.329481461017087,0.997100143773496,-5.46670627682258,0.725520609151367,"CDIPT-AS1","CDIPT antisense RNA 1 (head to head)",TRUE
+"231534_at",0.820536502908875,0.380524259889482,0.894776318935788,-5.55707555071632,0.574922419411578,"CDK1","cyclin dependent kinase 1",TRUE
+"210559_s_at",0.884769004468037,0.544744632717793,0.615115998317898,-5.75705599591792,0.26009225591868,"CDK1","cyclin dependent kinase 1",TRUE
+"203214_x_at",0.896458677219354,0.581095418003313,0.560003351943572,-5.78808223123725,0.222382452236571,"CDK1","cyclin dependent kinase 1",TRUE
+"203213_at",0.965986102042783,0.8405448341049,-0.2035735694499,-5.91951864826815,-0.0728144214111222,"CDK1","cyclin dependent kinase 1",TRUE
+"203468_at",0.748400542021017,0.240925431003419,-1.20497612765748,-5.25619479751624,-0.348198540477888,"CDK10","cyclin dependent kinase 10",TRUE
+"203469_s_at",0.755705810147566,0.249966887544924,-1.18140707179279,-5.28182353714529,-0.44800332526583,"CDK10","cyclin dependent kinase 10",TRUE
+"210622_x_at",0.760485797504507,0.25955967932751,-1.15708661676411,-5.30780542496452,-0.293764498623045,"CDK10","cyclin dependent kinase 10",TRUE
+"211289_x_at",0.874406257596174,0.52043806961989,0.65305858181833,-5.73406601342927,0.204148804767033,"CDK11A///CDK11B","cyclin dependent kinase 11A///cyclin dependent kinase 11B",TRUE
+"215329_s_at",0.87825462101175,0.530422624265353,0.637358926210767,-5.7437391278238,0.225895136119229,"CDK11A///CDK11B","cyclin dependent kinase 11A///cyclin dependent kinase 11B",TRUE
+"212401_s_at",0.909441642299191,0.623740965057135,-0.497495517319205,-5.81984818796982,-0.166495560388112,"CDK11A///CDK11B","cyclin dependent kinase 11A///cyclin dependent kinase 11B",TRUE
+"210474_s_at",0.986342822130003,0.933616989094014,0.0842465372001553,-5.9362271515595,0.021011180274602,"CDK11A///CDK11B","cyclin dependent kinase 11A///cyclin dependent kinase 11B",TRUE
+"207428_x_at",0.997654912087849,0.988513163373519,-0.0145604565491582,-5.93958022053474,-0.00513667264913664,"CDK11A///CDK11B","cyclin dependent kinase 11A///cyclin dependent kinase 11B",TRUE
+"213557_at",0.812224812938422,0.35649205783335,-0.941718287838817,-5.51673109473039,-0.748809820852093,"CDK12","cyclin dependent kinase 12",TRUE
+"225691_at",0.841206569659492,0.431208986805387,-0.80175666711224,-5.63135064756,-0.351879519990133,"CDK12","cyclin dependent kinase 12",TRUE
+"225697_at",0.863835356219448,0.489772802646171,-0.702352725704002,-5.70223005095927,-0.372766096681548,"CDK12","cyclin dependent kinase 12",TRUE
+"225694_at",0.8943345793428,0.570784991808433,-0.575450897172813,-5.77966998439294,-0.29045147923553,"CDK12","cyclin dependent kinase 12",TRUE
+"225690_at",0.947139951418903,0.760015932118912,-0.309256436614594,-5.89320804260949,-0.154767038074972,"CDK12","cyclin dependent kinase 12",TRUE
+"1556654_at",0.95930712748485,0.815539775118461,-0.236079323481387,-5.91257417310331,-0.307428292652912,"CDK12","cyclin dependent kinase 12",TRUE
+"219226_at",0.996625121774816,0.983155052594631,-0.0213531849373935,-5.93946140261156,-0.0105255981713075,"CDK12","cyclin dependent kinase 12",TRUE
+"1556655_s_at",0.998870448604467,0.995384791489944,-0.00584995366354741,-5.93966681250892,-0.00593503132907891,"CDK12","cyclin dependent kinase 12",TRUE
+"210965_x_at",0.697713925841949,0.168674257622062,1.42296629996335,-4.99883068109245,0.526341466047608,"CDK13","cyclin dependent kinase 13",TRUE
+"207318_s_at",0.700466202059297,0.17222436496174,-1.41068341170262,-5.01427970495485,-0.513721363070179,"CDK13","cyclin dependent kinase 13",TRUE
+"214287_s_at",0.739189560382301,0.226335198849945,1.24445665078341,-5.21228250003577,0.906013885216803,"CDK13","cyclin dependent kinase 13",TRUE
+"232266_x_at",0.864829185767069,0.492782596312524,-0.69743849486515,-5.70550311964606,-0.282754711975663,"CDK13","cyclin dependent kinase 13",TRUE
+"228991_at",0.961266469039336,0.824394782501225,-0.224540187115575,-5.9151563805325,-0.0707973218281577,"CDK13","cyclin dependent kinase 13",TRUE
+"207319_s_at",0.971216837324271,0.862866469289076,-0.174745635524339,-5.9248214379195,-0.0528126140449938,"CDK13","cyclin dependent kinase 13",TRUE
+"213987_s_at",0.983167907106595,0.918054948869137,-0.104063811803828,-5.93441031533106,-0.0463986970651078,"CDK13","cyclin dependent kinase 13",TRUE
+"204604_at",0.385141328160291,0.0126513731207295,2.71309394390376,-2.87690746570075,2.05696989775547,"CDK14","cyclin dependent kinase 14",TRUE
+"211502_s_at",0.42771041786555,0.0184069979558782,2.54474513569227,-3.19865007118573,2.05653884828163,"CDK14","cyclin dependent kinase 14",TRUE
+"243459_x_at",0.671905580757132,0.137871215555816,1.53938381435791,-4.84703230730428,0.681160191880002,"CDK14","cyclin dependent kinase 14",TRUE
+"239201_at",0.432192077156593,0.0193903459582098,2.52106714257702,-3.24308016405664,1.68384351359496,"CDK15","cyclin dependent kinase 15",TRUE
+"1552559_a_at",0.652357618974335,0.121392443136601,1.61073780665509,-4.74932495924448,0.543997325100623,"CDK15","cyclin dependent kinase 15",TRUE
+"1554826_at",0.732963666545614,0.217184816292309,-1.27021683480988,-5.18297483618185,-0.688131784153471,"CDK15","cyclin dependent kinase 15",TRUE
+"208823_s_at",0.764430688544079,0.264583197988261,-1.14461545537531,-5.32094453857671,-0.397019382011139,"CDK16","cyclin dependent kinase 16",TRUE
+"208824_x_at",0.776722799962286,0.294134427559688,-1.07456136420136,-5.39240498837017,-0.396787187049306,"CDK16","cyclin dependent kinase 16",TRUE
+"207239_s_at",0.778580821633075,0.298908269232863,-1.06372775670519,-5.40309697109567,-0.385852932578855,"CDK16","cyclin dependent kinase 16",TRUE
+"221918_at",0.803583569469174,0.342015399826296,-0.971029563520867,-5.49058002693701,-0.371671037707605,"CDK17","cyclin dependent kinase 17",TRUE
+"206474_at",0.879665002659836,0.534233370302813,-0.631409392915867,-5.74734572157446,-0.219227675130741,"CDK17","cyclin dependent kinase 17",TRUE
+"214797_s_at",0.988948717228281,0.94653590955251,-0.067821677909456,-5.93744334582298,-0.0497298699595712,"CDK18","cyclin dependent kinase 18",TRUE
+"212899_at",0.905934790589647,0.612406947602988,-0.513903355733056,-5.81186395094949,-0.238616213107381,"CDK19","cyclin dependent kinase 19",TRUE
+"235226_at",0.933922051839063,0.707256437913178,-0.380419813119703,-5.86944084447585,-0.148299242942912,"CDK19","cyclin dependent kinase 19",TRUE
+"212897_at",0.97589003385521,0.884653123776443,-0.146754245967237,-5.92919913622505,-0.0643542982432557,"CDK19","cyclin dependent kinase 19",TRUE
+"211706_s_at",0.982723176827697,0.9160481706222,0.106622255481472,-5.9341479148293,0.0751511423693749,"CDK19","cyclin dependent kinase 19",TRUE
+"211803_at",0.662575055303091,0.130357369436869,1.57098838297242,-4.80418329061887,1.13916830723968,"CDK2","cyclin dependent kinase 2",TRUE
+"204252_at",0.91050558382084,0.627603547095674,-0.491935500830529,-5.82249638321626,-0.152753175959521,"CDK2","cyclin dependent kinase 2",TRUE
+"211804_s_at",0.989586772349659,0.94931474205058,0.0642913804909178,-5.93767046348144,0.0275285262878864,"CDK2","cyclin dependent kinase 2",TRUE
+"205271_s_at",0.997654912087849,0.98848435907493,0.0145969709391514,-5.93957970198066,0.0060144890346514,"CDK20","cyclin dependent kinase 20",TRUE
+"201938_at",0.982909728377256,0.917237067613057,-0.105106442576267,-5.9343041490011,-0.0281833912570466,"CDK2AP1","cyclin dependent kinase 2 associated protein 1",TRUE
+"203252_at",0.979347742195592,0.900513317500158,0.126453694823138,-5.93189807969759,0.0503707400631903,"CDK2AP2","cyclin dependent kinase 2 associated protein 2",TRUE
+"202246_s_at",0.606900628956089,0.0807424814819678,-1.82996758350955,-4.42827694170062,-0.729081081881413,"CDK4","cyclin dependent kinase 4",TRUE
+"204247_s_at",0.319095917986488,0.00701292570953232,-2.97128859838413,-2.3659068544545,-1.73889858570658,"CDK5","cyclin dependent kinase 5",TRUE
+"204996_s_at",0.941947927515757,0.73919008281648,-0.337132031270997,-5.88447597076782,-0.205125955013963,"CDK5R1","cyclin dependent kinase 5 regulatory subunit 1",TRUE
+"204995_at",0.974982245454858,0.878489396048024,-0.154660214023339,-5.92803974806357,-0.0830847415108718,"CDK5R1","cyclin dependent kinase 5 regulatory subunit 1",TRUE
+"205852_at",0.827006487802341,0.395311999973634,-0.866855748931096,-5.58016651613103,-0.643777010073545,"CDK5R2","cyclin dependent kinase 5 regulatory subunit 2",TRUE
+"218315_s_at",0.62443408969229,0.0959806875130134,1.73861741794796,-4.56575437826341,0.556901301996492,"CDK5RAP1","CDK5 regulatory subunit associated protein 1",TRUE
+"220935_s_at",0.406142422607459,0.0153468723384913,-2.62684906142245,-3.04298001380293,-0.945408102527088,"CDK5RAP2","CDK5 regulatory subunit associated protein 2",TRUE
+"233540_s_at",0.424010380516768,0.0179000352639554,-2.55741805420276,-3.17478336586962,-0.983303904169038,"CDK5RAP2","CDK5 regulatory subunit associated protein 2",TRUE
+"243153_at",0.509163975230892,0.033851139459795,2.26188889468429,-3.7144933849601,1.28831130390979,"CDK5RAP2","CDK5 regulatory subunit associated protein 2",TRUE
+"218740_s_at",0.947778780715578,0.762239937904324,-0.306294699211614,-5.89409197086041,-0.112175496699528,"CDK5RAP3","CDK5 regulatory subunit associated protein 3",TRUE
+"224848_at",0.264625316305831,0.00402201440969631,3.20884215992729,-1.88055037367301,2.40414750436336,"CDK6","cyclin dependent kinase 6",TRUE
+"207143_at",0.272612749300726,0.00431792667388072,3.1787630122625,-1.94268703883871,1.67602966709857,"CDK6","cyclin dependent kinase 6",TRUE
+"224851_at",0.372215385165384,0.0112714783438723,2.76422380712311,-2.77729234422315,3.86041841746896,"CDK6","cyclin dependent kinase 6",TRUE
+"224847_at",0.384586587899771,0.0125604249345398,2.71629736369704,-2.87069101363351,3.02934056663122,"CDK6","cyclin dependent kinase 6",TRUE
+"235287_at",0.391418712765422,0.0131940500709039,2.6944201780696,-2.91307809898579,2.87962154937649,"CDK6","cyclin dependent kinase 6",TRUE
+"231198_at",0.523369751179323,0.0387425507376684,2.19732128096577,-3.82730780406345,1.11479892585657,"CDK6","cyclin dependent kinase 6",TRUE
+"243000_at",0.552420073963858,0.050136503701066,2.07167651373731,-4.04098744945676,2.10806723886011,"CDK6","cyclin dependent kinase 6",TRUE
+"211297_s_at",0.864829185767069,0.492736176130046,0.697514156335959,-5.70545289232701,0.241928626424185,"CDK7","cyclin dependent kinase 7",TRUE
+"204831_at",0.746259710622309,0.237794509180568,1.21329263685373,-5.24704656626992,0.465182825599653,"CDK8","cyclin dependent kinase 8",TRUE
+"1553112_s_at",0.799008022536007,0.333624818344335,0.988407545043336,-5.47473035291382,0.389760718182709,"CDK8","cyclin dependent kinase 8",TRUE
+"1553113_s_at",0.801587742916188,0.338864535954386,0.977520732662415,-5.4846896993272,0.441993281501789,"CDK8","cyclin dependent kinase 8",TRUE
+"228901_at",0.685360765794715,0.154019711555915,-1.47598313203396,-4.93089546725712,-0.80056763701095,"CDK9","cyclin dependent kinase 9",TRUE
+"236023_at",0.832689968870694,0.409423034899879,0.840835421957653,-5.60107267412465,0.407916817395937,"CDK9","cyclin dependent kinase 9",TRUE
+"203198_at",0.843816788557882,0.43979911644734,-0.786686589688523,-5.64266528974596,-0.399800119215179,"CDK9","cyclin dependent kinase 9",TRUE
+"1561026_a_at",0.771855357662161,0.282060723293827,1.10253635303796,-5.36434882874584,0.701071290359921,"CDKAL1","CDK5 regulatory subunit associated protein 1 like 1",TRUE
+"220039_s_at",0.82414533853973,0.391580203101694,0.873836734316502,-5.57445677223112,0.514822337945619,"CDKAL1","CDK5 regulatory subunit associated protein 1 like 1",TRUE
+"1561025_at",0.899255754020412,0.589651907405319,0.547287540862725,-5.79484018580337,0.278695327407707,"CDKAL1","CDK5 regulatory subunit associated protein 1 like 1",TRUE
+"214877_at",0.961212424803935,0.82405980513289,0.224976125863983,-5.91506116673647,0.150815792938888,"CDKAL1","CDK5 regulatory subunit associated protein 1 like 1",TRUE
+"235512_at",0.485152361954952,0.0279245447292589,2.35267832616666,-3.55261900252098,1.99921971893265,"CDKL1","cyclin dependent kinase like 1",TRUE
+"207766_at",0.640987277293074,0.111481989972109,1.65764485488877,-4.68322796788986,1.14008397983933,"CDKL1","cyclin dependent kinase like 1",TRUE
+"1555286_at",0.994050962712312,0.972233657632206,0.0352022902790652,-5.93907992953772,0.0277334289229594,"CDKL1","cyclin dependent kinase like 1",TRUE
+"236331_at",0.647518308302168,0.118589985405565,1.62366612262579,-4.73125340932627,1.03409782887445,"CDKL2","cyclin dependent kinase like 2",TRUE
+"207073_at",0.855995474999686,0.469337582981995,0.736191054830491,-5.67909879806945,0.444886660445369,"CDKL2","cyclin dependent kinase like 2",TRUE
+"241911_at",0.68680805784522,0.155365889335825,-1.47094678962536,-4.93743566755217,-1.14599901477964,"CDKL3","cyclin dependent kinase like 3",TRUE
+"1561190_at",0.888830748858811,0.556107595040113,0.597689000740016,-5.76717084208959,0.231752654192031,"CDKL3","cyclin dependent kinase like 3",TRUE
+"219831_at",0.929325066560006,0.689236527933663,-0.405172066145885,-5.86003983077673,-0.212692499722818,"CDKL3","cyclin dependent kinase like 3",TRUE
+"236017_at",0.99753019043878,0.987544592468697,0.0157882977863704,-5.93956207108288,0.00685734072515753,"CDKL3","cyclin dependent kinase like 3",TRUE
+"206575_at",0.743869497380606,0.234669172391415,-1.2216771506117,-5.23776836801824,-0.518101655369029,"CDKL5","cyclin dependent kinase like 5",TRUE
+"227004_at",0.885312914741353,0.546678559251142,-0.612136556948053,-5.75880517546628,-0.279202119059062,"CDKL5","cyclin dependent kinase like 5",TRUE
+"216923_at",0.968066640321622,0.849968424872742,-0.191383104572691,-5.92185930947307,-0.0597116955181267,"CDKL5","cyclin dependent kinase like 5",TRUE
+"202284_s_at",0.980264692225439,0.907621769801904,-0.117373251224278,-5.93297569206801,-0.105125774990981,"CDKN1A","cyclin dependent kinase inhibitor 1A",TRUE
+"209112_at",0.683017520100356,0.151436860510041,-1.48574712573357,-4.91816455100356,-0.687337730481824,"CDKN1B","cyclin dependent kinase inhibitor 1B",TRUE
+"216894_x_at",0.668193690220211,0.134272671878715,1.55433745162309,-4.82684396666877,1.46462166622636,"CDKN1C","cyclin dependent kinase inhibitor 1C",TRUE
+"213348_at",0.729273475042162,0.211643824190086,1.28622369829401,-5.16450527675955,0.91898288348002,"CDKN1C","cyclin dependent kinase inhibitor 1C",TRUE
+"213182_x_at",0.843475287501313,0.438451557841888,0.789038613378716,-5.64091269281384,0.76565057629749,"CDKN1C","cyclin dependent kinase inhibitor 1C",TRUE
+"219533_at",0.893914276642775,0.569988663542582,0.576649847698004,-5.77900779950836,0.308433374864753,"CDKN1C","cyclin dependent kinase inhibitor 1C",TRUE
+"219534_x_at",0.958933497686198,0.814291073261542,0.237709134551149,-5.91219908467677,0.229741562210399,"CDKN1C","cyclin dependent kinase inhibitor 1C",TRUE
+"211156_at",0.587626678796111,0.066818519270599,1.92761946735333,-4.2757791811472,1.21256318285602,"CDKN2A","cyclin dependent kinase inhibitor 2A",TRUE
+"209644_x_at",0.686082821383144,0.154370203359039,1.47466843632995,-4.93260447511716,1.70151883297381,"CDKN2A","cyclin dependent kinase inhibitor 2A",TRUE
+"207039_at",0.739340500562926,0.226678098833635,1.24350691282384,-5.2133531740848,2.12310462893177,"CDKN2A","cyclin dependent kinase inhibitor 2A",TRUE
+"220505_at",0.966194888753897,0.842493668428753,0.201050007566243,-5.92001500548086,0.134767301520691,"CDKN2A-AS1","CDKN2A antisense RNA 1 (head to head)",TRUE
+"218929_at",0.868100325087973,0.50210891048161,-0.682318951996734,-5.71543570369868,-0.3125548448569,"CDKN2AIP","CDKN2A interacting protein",TRUE
+"1554348_s_at",0.543311492243675,0.0462870586350442,-2.11095331973318,-3.9750482988063,-0.807680885307742,"CDKN2AIPNL","CDKN2A interacting protein N-terminal like",TRUE
+"235006_at",0.923376218980614,0.671011871939278,-0.430470377310465,-5.84982918627661,-0.14224401953428,"CDKN2AIPNL","CDKN2A interacting protein N-terminal like",TRUE
+"207530_s_at",0.652357618974335,0.12141119357776,1.61065215145678,-4.74944431765462,1.9259468467374,"CDKN2B","cyclin dependent kinase inhibitor 2B",TRUE
+"236313_at",0.903341483403337,0.603351153011853,0.527116358044486,-5.80525083857219,0.977654135119223,"CDKN2B","cyclin dependent kinase inhibitor 2B",TRUE
+"1559884_at",0.943512938262733,0.747430303174978,0.326071074123627,-5.88803005320345,0.132891699804767,"CDKN2B-AS1","CDKN2B antisense RNA 1",TRUE
+"211792_s_at",0.597879550155311,0.0752639397632927,-1.86649033839738,-4.37189579550466,-0.799558404926364,"CDKN2C","cyclin dependent kinase inhibitor 2C",TRUE
+"204159_at",0.615637099066718,0.0859192212426735,-1.79738206390744,-4.47790424306451,-0.882593263027486,"CDKN2C","cyclin dependent kinase inhibitor 2C",TRUE
+"210240_s_at",0.452515768626633,0.0217753815684805,2.46798945143854,-3.34189035284061,1.11948613691725,"CDKN2D","cyclin dependent kinase inhibitor 2D",TRUE
+"213586_at",0.980264692225439,0.907753985704493,0.117204454784562,-5.93299496498246,0.0569355334442787,"CDKN2D","cyclin dependent kinase inhibitor 2D",TRUE
+"1555758_a_at",0.805746717966166,0.345199069423678,-0.964512205304664,-5.49645807725156,-0.356907100221719,"CDKN3","cyclin dependent kinase inhibitor 3",TRUE
+"209714_s_at",0.908064975008433,0.618580338256774,-0.504948936571824,-5.8162526000984,-0.194430133011986,"CDKN3","cyclin dependent kinase inhibitor 3",TRUE
+"1568696_at",0.860696412805564,0.480234086002936,0.718043166943136,-5.69163307506536,0.381869986584939,"CDNF","cerebral dopamine neurotrophic factor",TRUE
+"243706_at",0.636860247875294,0.107915896230253,1.67538485051515,-4.65785286603382,0.76432400011827,"CDO1","cysteine dioxygenase type 1",TRUE
+"204154_at",0.731548533938014,0.215209864475007,1.27588561947683,-5.17645645564515,0.868084818758947,"CDO1","cysteine dioxygenase type 1",TRUE
+"1563677_at",0.67606695078322,0.142629950609709,-1.52009492383161,-4.8728447532974,-1.03104871574725,"CDON","cell adhesion associated, oncogene regulated",TRUE
+"227526_at",0.883190352125328,0.541086733130752,0.620766834144625,-5.75371599956494,0.427565659041854,"CDON","cell adhesion associated, oncogene regulated",TRUE
+"207230_at",0.899808883319249,0.59204077133603,0.543753768735299,-5.79669147615656,0.526636334690937,"CDON","cell adhesion associated, oncogene regulated",TRUE
+"1556065_at",0.497725944448536,0.0307783862377275,-2.3069583716131,-3.63459827120525,-1.14786750351957,"CDPF1","cysteine rich DPF motif domain containing 1",TRUE
+"227590_at",0.85829382652909,0.47403531717591,0.728337070835655,-5.6845598226915,0.209453867833355,"CDPF1","cysteine rich DPF motif domain containing 1",TRUE
+"207276_at",0.736739711864971,0.222214441488162,1.25595682382015,-5.19926222565377,0.656104225117532,"CDR1","cerebellar degeneration related protein 1",TRUE
+"213230_at",0.832605695407954,0.409285681050777,-0.841085912818115,-5.60087424902237,-0.484753516519628,"CDR2L","cerebellar degeneration related protein 2 like",TRUE
+"216003_at",0.682504456039784,0.149958645015781,1.49139637634827,-4.91076782875991,0.991848053520616,"CDRT1","CMT1A duplicated region transcript 1",TRUE
+"208279_s_at",0.701770809769283,0.173304216852143,1.40698746415518,-5.0189067831537,1.15588274752086,"CDRT1","CMT1A duplicated region transcript 1",TRUE
+"208280_at",0.883410339479976,0.541448569943377,0.620206952048248,-5.75404823841757,0.250975084378495,"CDRT1","CMT1A duplicated region transcript 1",TRUE
+"215999_at",0.983498417373669,0.919576482429113,0.102124482186649,-5.93460497610304,0.0694773877219381,"CDRT1","CMT1A duplicated region transcript 1",TRUE
+"240760_at",0.941306621461417,0.737113851711408,0.339925706484671,-5.88355976349151,0.281508554173885,"CDRT15","CMT1A duplicated region transcript 15",TRUE
+"240889_at",0.85069818933195,0.453663410927189,-0.762739255183389,-5.66022851675263,-0.567584777622892,"CDRT15L2","CMT1A duplicated region transcript 15-like 2",TRUE
+"222063_s_at",0.86333554038125,0.487614577118044,0.70588726094395,-5.69986236698349,0.572705917052478,"CDS1","CDP-diacylglycerol synthase 1",TRUE
+"205709_s_at",0.867834927246481,0.500866223429787,0.684324289714783,-5.71413028620284,0.469543981028229,"CDS1","CDP-diacylglycerol synthase 1",TRUE
+"226185_at",0.877510999184545,0.527638402901805,0.641720469821829,-5.74107451170413,0.386546206487461,"CDS1","CDP-diacylglycerol synthase 1",TRUE
+"226187_at",0.943988850936011,0.749775900591426,0.322930180100123,-5.88901788890364,0.173667739598011,"CDS1","CDP-diacylglycerol synthase 1",TRUE
+"233630_at",0.698509433176315,0.169847487387636,1.41888437087419,-5.00397700577894,0.709987912123753,"CDS2","CDP-diacylglycerol synthase 2",TRUE
+"228861_at",0.867159108376357,0.499179454260027,0.687050763224995,-5.71234955741304,0.197525602499532,"CDS2","CDP-diacylglycerol synthase 2",TRUE
+"212862_at",0.877074739399942,0.526261982744454,0.643881292510178,-5.73974792221553,0.261801674561413,"CDS2","CDP-diacylglycerol synthase 2",TRUE
+"212864_at",0.935318317015903,0.712336918734703,-0.373485413528198,-5.87196982320125,-0.164255206719524,"CDS2","CDP-diacylglycerol synthase 2",TRUE
+"228456_s_at",0.978999293602992,0.898486398293279,0.129044874143212,-5.9315758766364,0.047596988522562,"CDS2","CDP-diacylglycerol synthase 2",TRUE
+"206193_s_at",0.94895689004559,0.768840265870999,0.297521281191124,-5.896660911022,0.455063600102909,"CDSN","corneodesmosin",TRUE
+"206192_at",0.986145735582101,0.93234149526678,0.0858693879751604,-5.9360927335749,0.0935283203178949,"CDSN","corneodesmosin",TRUE
+"228868_x_at",0.953930144147255,0.787291153625985,0.273119171120504,-5.90341662051078,0.115760123897671,"CDT1","chromatin licensing and DNA replication factor 1",TRUE
+"209832_s_at",0.99667999022307,0.983463753003582,-0.0209618061277894,-5.93946946878296,-0.00827607377942563,"CDT1","chromatin licensing and DNA replication factor 1",TRUE
+"213554_s_at",0.911028479628096,0.62885033331993,0.490144166714371,-5.82334339008252,0.221038826369059,"CDV3","CDV3 homolog",TRUE
+"213548_s_at",0.932830928398943,0.703724585627445,0.385251670004314,-5.86765154422671,0.190354794980463,"CDV3","CDV3 homolog",TRUE
+"212010_s_at",0.970540753946729,0.859840266054134,-0.178644493887792,-5.92415136210556,-0.0707050272380236,"CDV3","CDV3 homolog",TRUE
+"206430_at",0.980009054680439,0.905514010690729,0.120064645022726,-5.93266465112422,0.0585338309393189,"CDX1","caudal type homeobox 1",TRUE
+"206387_at",0.67606695078322,0.142590105958183,1.5202542191715,-4.87263264453892,0.846087540376395,"CDX2","caudal type homeobox 2",TRUE
+"231606_at",0.904345087496977,0.606971369053245,0.521822952273067,-5.80791982340987,0.346573255810708,"CDX2","caudal type homeobox 2",TRUE
+"221340_at",0.827825169467994,0.39700597433783,0.863700927065885,-5.58273287349717,0.280787601253309,"CDX4","caudal type homeobox 4",TRUE
+"207647_at",0.620912785033482,0.090650968769485,1.76904833733909,-4.52052914288628,1.17282320513188,"CDY1","chromodomain Y-linked 1",TRUE
+"207646_s_at",0.90115698600215,0.597685279748758,0.53543166219665,-5.80100524477977,0.330822295734239,"CDY1B///CDY2B///CDY2A///CDY1","chromodomain Y-linked 1B///chromodomain Y-linked 2B///chromodomain Y-linked 2A///chromodomain Y-linked 1",TRUE
+"203099_s_at",0.752913428584105,0.24612964876228,1.1913305419643,-5.27108658842424,0.538665508088839,"CDYL","chromodomain Y-like",TRUE
+"203100_s_at",0.774011928861764,0.285699954582247,1.0940147224109,-5.37296320605457,0.478385123575285,"CDYL","chromodomain Y-like",TRUE
+"203098_at",0.774230543658252,0.287086380629563,1.09078890439025,-5.37620861006712,0.478285841702974,"CDYL","chromodomain Y-like",TRUE
+"227290_at",0.116813277814384,0.000630268257068922,-3.97740969186637,-0.249402262549909,-3.6464225402592,"CDYL2","chromodomain Y-like 2",TRUE
+"1553647_at",0.711870026066379,0.185340031565431,-1.36698654980898,-5.06834210357978,-0.574673609775274,"CDYL2","chromodomain Y-like 2",TRUE
+"209498_at",0.739367922105944,0.227426705848729,1.24143727749182,-5.21568391324374,1.75494287780399,"CEACAM1","carcinoembryonic antigen related cell adhesion molecule 1",TRUE
+"206576_s_at",0.769429807058463,0.276918021418492,1.11471552871686,-5.35193408548221,0.541876148768258,"CEACAM1","carcinoembryonic antigen related cell adhesion molecule 1",TRUE
+"211889_x_at",0.778665200947143,0.299041129418978,1.06342802160391,-5.40339140869874,1.23210924685275,"CEACAM1","carcinoembryonic antigen related cell adhesion molecule 1",TRUE
+"210610_at",0.943010360246042,0.744288987369066,0.330282735796117,-5.88669060061973,0.25754080334772,"CEACAM1","carcinoembryonic antigen related cell adhesion molecule 1",TRUE
+"211883_x_at",0.977874971442423,0.893066874059642,0.135977599751398,-5.93068173916361,0.0852577754646902,"CEACAM1","carcinoembryonic antigen related cell adhesion molecule 1",TRUE
+"230504_at",0.896159990898752,0.579150168067835,0.562907181097927,-5.78651783579072,0.331045597924768,"CEACAM19","carcinoembryonic antigen related cell adhesion molecule 19",TRUE
+"216605_s_at",0.946391057046703,0.757648680346189,0.312412041896294,-5.89225698155939,0.235749685494655,"CEACAM21","carcinoembryonic antigen related cell adhesion molecule 21",TRUE
+"214907_at",0.993213867476782,0.967654438993846,-0.0410110053103887,-5.9388643212273,-0.0274639725790564,"CEACAM21","carcinoembryonic antigen related cell adhesion molecule 21",TRUE
+"208052_x_at",0.80994623091211,0.353724665783619,0.947258297325073,-5.51184464407974,0.237287028712684,"CEACAM3","carcinoembryonic antigen related cell adhesion molecule 3",TRUE
+"217209_at",0.823933875444718,0.39121574054558,-0.874520832582963,-5.5738949599294,-0.376209065022937,"CEACAM3","carcinoembryonic antigen related cell adhesion molecule 3",TRUE
+"210789_x_at",0.95576368777688,0.798296485225547,-0.258645342182912,-5.9071526420682,-0.155884864426739,"CEACAM3","carcinoembryonic antigen related cell adhesion molecule 3",TRUE
+"207205_at",0.990810941805126,0.956237231547324,0.0555004188584162,-5.93818329325838,0.0165579056629408,"CEACAM4","carcinoembryonic antigen related cell adhesion molecule 4",TRUE
+"201884_at",0.869684594766105,0.507192598741212,-0.674144386989737,-5.72071920013916,-0.683330610051899,"CEACAM5","carcinoembryonic antigen related cell adhesion molecule 5",TRUE
+"217291_at",0.9486224899297,0.766133027669424,0.301116926824122,-5.89561702118787,0.172521241641173,"CEACAM5","carcinoembryonic antigen related cell adhesion molecule 5",TRUE
+"203757_s_at",0.842917136850585,0.436749850036352,-0.792015123183011,-5.63868770291656,-1.42300159235713,"CEACAM6","carcinoembryonic antigen related cell adhesion molecule 6",TRUE
+"211657_at",0.857148066512338,0.472038159835237,-0.731670421787721,-5.68224887329914,-1.07329555043271,"CEACAM6","carcinoembryonic antigen related cell adhesion molecule 6",TRUE
+"206199_at",0.713330901550199,0.187917495682227,-1.35868941348564,-5.07844768527277,-0.611059171222267,"CEACAM7","carcinoembryonic antigen related cell adhesion molecule 7",TRUE
+"211848_s_at",0.857110337466729,0.471767325024668,-0.732123096701133,-5.68193426949838,-0.402818877819737,"CEACAM7","carcinoembryonic antigen related cell adhesion molecule 7",TRUE
+"206198_s_at",0.994098505325585,0.972904343421249,0.0343516379410565,-5.93910874553795,0.0334123926606522,"CEACAM7","carcinoembryonic antigen related cell adhesion molecule 7",TRUE
+"206676_at",0.740476003158683,0.229694917470945,-1.23519797567294,-5.22269013131632,-0.983043108049696,"CEACAM8","carcinoembryonic antigen related cell adhesion molecule 8",TRUE
+"204039_at",0.51531387545335,0.0355410077470233,-2.23867353942944,-3.75528248286945,-2.80009642915481,"CEBPA","CCAAT/enhancer binding protein alpha",TRUE
+"220465_at",0.93789466363241,0.725450791442217,-0.355671074997383,-5.87825618794896,-0.095336488770764,"CEBPA-AS1","CEBPA antisense RNA 1 (head to head)",TRUE
+"212501_at",0.833947935066508,0.41169610674863,0.836697772560853,-5.60434230467603,0.441368079557856,"CEBPB","CCAAT/enhancer binding protein beta",TRUE
+"213006_at",0.826140850652187,0.394048475248384,-0.869214600657842,-5.57824197362977,-0.421067384778821,"CEBPD","CCAAT/enhancer binding protein delta",TRUE
+"203973_s_at",0.978255630670068,0.894910922212123,0.133617920794092,-5.9309913175343,0.0899660720093998,"CEBPD","CCAAT/enhancer binding protein delta",TRUE
+"214523_at",0.680586794685785,0.148327408140325,1.49768335137983,-4.9025095938704,0.420955257673385,"CEBPE","CCAAT/enhancer binding protein epsilon",TRUE
+"225527_at",0.913140067375992,0.635379582021511,-0.480789527161166,-5.82771752918366,-0.150265600684342,"CEBPG","CCAAT/enhancer binding protein gamma",TRUE
+"204203_at",0.990918916504081,0.957300130666711,-0.0541510436740734,-5.93825534914684,-0.0171121135340062,"CEBPG","CCAAT/enhancer binding protein gamma",TRUE
+"203341_at",0.510464254842122,0.0339936049726597,2.2598913539299,-3.71801290271549,0.662504262785676,"CEBPZ","CCAAT/enhancer binding protein zeta",TRUE
+"1564381_s_at",0.393258278493143,0.0134520744358327,2.68579451947826,-2.9297467905167,0.752662275363093,"CEBPZOS","CEBPZ opposite strand",TRUE
+"231819_at",0.436430423324629,0.0199237372952588,2.50868857453452,-3.26622243673887,0.942391643347584,"CEBPZOS","CEBPZ opposite strand",TRUE
+"229746_x_at",0.470726957161354,0.0253047865236724,2.39860715622112,-3.46935086941434,0.756206132232229,"CEBPZOS","CEBPZ opposite strand",TRUE
+"219505_at",0.774230543658252,0.286524353719854,-1.09209522244431,-5.37489538877717,-0.672813833076895,"CECR1","cat eye syndrome chromosome region, candidate 1",TRUE
+"233695_s_at",0.910860516303107,0.628114751644738,0.491200824880064,-5.8228441294519,0.221483885564927,"CECR2","CECR2, histone acetyl-lysine reader",TRUE
+"239752_at",0.982243328340126,0.914485969809226,-0.108614410816495,-5.93393918605881,-0.100290962218372,"CECR2","CECR2, histone acetyl-lysine reader",TRUE
+"223729_at",0.995032257518762,0.976850776197517,0.0293467553132239,-5.93926401507802,0.0146188162091221,"CECR2","CECR2, histone acetyl-lysine reader",TRUE
+"1564352_at",0.993952584307899,0.971694433321048,0.0358862250756533,-5.93905625001459,0.0141090508358923,"CECR3","cat eye syndrome chromosome region, candidate 3 (non-protein coding)",TRUE
+"218592_s_at",0.636147339487472,0.1076327909096,-1.67681432101938,-4.65579923987775,-0.540694921193172,"CECR5","cat eye syndrome chromosome region, candidate 5",TRUE
+"1559920_a_at",0.773107052530371,0.283911753167538,-1.09819210050126,-5.36874779063091,-0.442347054791733,"CECR5-AS1","CECR5 antisense RNA 1",TRUE
+"224393_s_at",0.862634144901168,0.48576036199984,-0.70893113085855,-5.69781428955078,-0.466804764766191,"CECR6","cat eye syndrome chromosome region, candidate 6",TRUE
+"243048_at",0.60020024844319,0.0765149357944892,1.85795145055499,-4.38514844288022,1.94993905224816,"CECR7","cat eye syndrome chromosome region, candidate 7 (non-protein coding)",TRUE
+"1567687_at",0.702630084418366,0.17418709877962,1.40397931758541,-5.02266539718726,0.992544034964901,"CECR9","cat eye syndrome chromosome region, candidate 9 (non-protein coding)",TRUE
+"1567686_at",0.76912869907427,0.275011765561934,1.11927181791239,-5.34725859716585,0.468194451637207,"CECR9","cat eye syndrome chromosome region, candidate 9 (non-protein coding)",TRUE
+"1553970_s_at",0.774230543658252,0.288134270188712,1.08835821448741,-5.37864841782853,1.04849620836951,"CEL","carboxyl ester lipase",TRUE
+"205910_s_at",0.819018525257656,0.375258744842908,0.904889339936221,-5.54854469039143,0.854883908467678,"CEL","carboxyl ester lipase",TRUE
+"224198_at",0.980009054680439,0.905501022549137,0.12008123235261,-5.93266271231459,0.0694930296062166,"CELA1","chymotrypsin like elastase family member 1",TRUE
+"206447_at",0.75147824277753,0.244728308467926,-1.194983416684,-5.26711456930439,-0.602189630711868,"CELA2A///CELA2B","chymotrypsin like elastase family member 2A///chymotrypsin like elastase family member 2B",TRUE
+"206446_s_at",0.973499570783928,0.872475474197897,0.162383767770055,-5.92684851732542,0.102313441395749,"CELA2A///CELA2B","chymotrypsin like elastase family member 2A///chymotrypsin like elastase family member 2B",TRUE
+"207077_at",0.754579670006269,0.248036205098349,1.18638565240135,-5.27644662492497,0.789699004892254,"CELA2B","chymotrypsin like elastase family member 2B",TRUE
+"211738_x_at",0.75067385436597,0.243638233074563,1.1978357803909,-5.26400564354398,0.314241879562613,"CELA3A","chymotrypsin like elastase family member 3A",TRUE
+"210080_x_at",0.819018525257656,0.373734890355841,-0.907833520841366,-5.54604447251042,-0.858055707423623,"CELA3A","chymotrypsin like elastase family member 3A",TRUE
+"206151_x_at",0.972133485197102,0.866341180909535,0.170272346828626,-5.92557207715685,0.126611541648523,"CELA3B","chymotrypsin like elastase family member 3B",TRUE
+"235865_at",0.721094750464234,0.197273399737599,1.32930488872793,-5.11382242374745,0.678114163969692,"CELF1","CUGBP, Elav-like family member 1",TRUE
+"209489_at",0.814808294657809,0.365668973498284,-0.923551411276498,-5.53257002700175,-0.301510257033332,"CELF1","CUGBP, Elav-like family member 1",TRUE
+"1555467_a_at",0.895213601869362,0.573090475997665,-0.571984553053977,-5.78157694970453,-0.193253564966968,"CELF1","CUGBP, Elav-like family member 1",TRUE
+"221743_at",0.955515814503015,0.796110206704538,-0.26151606953778,-5.90642770318063,-0.0680618506837991,"CELF1","CUGBP, Elav-like family member 1",TRUE
+"235297_at",0.961212424803935,0.823668568621285,-0.225485336582918,-5.91494971683534,-0.0581995263307924,"CELF1","CUGBP, Elav-like family member 1",TRUE
+"221742_at",0.962741248200658,0.830452002692917,-0.216664918304972,-5.91684477221393,-0.0509524073582828,"CELF1","CUGBP, Elav-like family member 1",TRUE
+"204113_at",0.974670398319743,0.876019488143417,-0.157831072155761,-5.92755770130209,-0.0479481895536331,"CELF1","CUGBP, Elav-like family member 1",TRUE
+"202158_s_at",0.627092759817312,0.0981486410846989,-1.72665172761554,-4.58337806465247,-2.35805174155598,"CELF2","CUGBP, Elav-like family member 2",TRUE
+"227178_at",0.747587302711183,0.239401639171472,-1.20901345816441,-5.25176051510268,-0.707679253121759,"CELF2","CUGBP, Elav-like family member 2",TRUE
+"1556323_at",0.829803290928719,0.401421653318514,0.855517812939336,-5.58934900854858,0.562712226698571,"CELF2","CUGBP, Elav-like family member 2",TRUE
+"1554569_a_at",0.923494952314901,0.671804992739736,0.429363574359818,-5.8502886130473,0.191335160569958,"CELF2","CUGBP, Elav-like family member 2",TRUE
+"242268_at",0.961561244483099,0.825922118782408,-0.222553077804953,-5.91558805877668,-0.188224871561935,"CELF2","CUGBP, Elav-like family member 2",TRUE
+"202156_s_at",0.968317867540591,0.851322753997415,-0.189633609366252,-5.92218341235443,-0.24473581764157,"CELF2","CUGBP, Elav-like family member 2",TRUE
+"202157_s_at",0.998870448604467,0.995929327948744,-0.00515972600289183,-5.93967051378655,-0.00605957145561931,"CELF2","CUGBP, Elav-like family member 2",TRUE
+"1560255_at",0.596889565909742,0.073122383401252,1.88139963766011,-4.34865322356652,1.33022397991407,"CELF2-AS1","CELF2 antisense RNA 1",TRUE
+"215045_at",0.968035667633768,0.849352738834749,0.192178637245832,-5.92171095205834,0.131431206774216,"CELF3","CUGBP, Elav-like family member 3",TRUE
+"206817_x_at",0.971242929121865,0.863668317788036,0.173713027897777,-5.92499643742705,0.0600102629574719,"CELF3","CUGBP, Elav-like family member 3",TRUE
+"231220_at",0.411113813456764,0.0162941679700193,2.59990468483749,-3.09433623702927,2.18610435817979,"CELF4","CUGBP, Elav-like family member 4",TRUE
+"223654_s_at",0.605167906652425,0.078997700582836,1.84135894396705,-4.41077704058669,1.65549415951872,"CELF4","CUGBP, Elav-like family member 4",TRUE
+"232719_at",0.680160698079016,0.14741028986975,1.5012428483559,-4.89782166905595,1.0811771322605,"CELF4","CUGBP, Elav-like family member 4",TRUE
+"243665_s_at",0.724697226571437,0.20229225554519,1.31398941451712,-5.13200204908711,1.08895546284163,"CELF4","CUGBP, Elav-like family member 4",TRUE
+"223653_x_at",0.812302873476553,0.357327393262612,0.940051737695779,-5.51819589545491,0.575364113888566,"CELF4","CUGBP, Elav-like family member 4",TRUE
+"243666_at",0.906476756086155,0.613726046987931,0.511986466192179,-5.81280976537875,0.520015460447638,"CELF4","CUGBP, Elav-like family member 4",TRUE
+"238966_at",0.929126743655924,0.688382361514143,0.406351648214458,-5.85957725785095,0.240077118156856,"CELF4","CUGBP, Elav-like family member 4",TRUE
+"231744_at",0.677013732819214,0.143803790790919,1.51541830840136,-4.87906397277974,0.843707150485354,"CELF5","CUGBP, Elav-like family member 5",TRUE
+"232416_at",0.821896104057596,0.384975668390092,0.886298339694955,-5.56415878554067,0.588273182819653,"CELF5","CUGBP, Elav-like family member 5",TRUE
+"230497_at",0.896599256925387,0.581316756646678,0.5596732507661,-5.78825957156159,0.488354440897993,"CELF5","CUGBP, Elav-like family member 5",TRUE
+"227775_at",0.848376789225697,0.448450779684111,0.771689975540792,-5.65372393031059,0.354893712919528,"CELF6","CUGBP, Elav-like family member 6",TRUE
+"207412_x_at",0.893462835798285,0.568313417714438,0.579174887054176,-5.77760884593104,0.392337759479493,"CELP","carboxyl ester lipase pseudogene",TRUE
+"217262_s_at",0.770807031642694,0.279356069768954,1.10892132832085,-5.35785544859204,0.650707062483931,"CELSR1","cadherin EGF LAG seven-pass G-type receptor 1",TRUE
+"204539_s_at",0.813631136157676,0.364401773615785,0.926041690286505,-5.53041563973281,0.615056884223678,"CELSR1","cadherin EGF LAG seven-pass G-type receptor 1",TRUE
+"41660_at",0.93565329131222,0.713211665053333,0.372293352927143,-5.87239994509141,0.430565557710938,"CELSR1","cadherin EGF LAG seven-pass G-type receptor 1",TRUE
+"204029_at",0.803489780415187,0.341655008150646,-0.97176993621666,-5.48990999411954,-0.747461851186861,"CELSR2","cadherin EGF LAG seven-pass G-type receptor 2",TRUE
+"36499_at",0.822173415758858,0.386191633828122,-0.883993620777882,-5.5660735452,-0.630796295941211,"CELSR2","cadherin EGF LAG seven-pass G-type receptor 2",TRUE
+"205165_at",0.180091551279879,0.0016436339110866,-3.58314212716459,-1.09449540941839,-3.267290419895,"CELSR3","cadherin EGF LAG seven-pass G-type receptor 3",TRUE
+"40020_at",0.456898036702485,0.0224606888533689,-2.45373889217751,-3.36822981493518,-1.57812845613845,"CELSR3","cadherin EGF LAG seven-pass G-type receptor 3",TRUE
+"216116_at",0.962555471240652,0.829757662970894,-0.217566940728903,-5.91665442851434,-0.062902863822853,"CELSR3-AS1","CELSR3 antisense RNA 1 (head to head)",TRUE
+"1554685_a_at",0.937113154905832,0.720805505642976,-0.361967685652393,-5.87606887958437,-0.245990641325339,"CEMIP","cell migration inducing hyaluronan binding protein",TRUE
+"212942_s_at",0.939452234779565,0.728898093307434,0.351007781132604,-5.87985167584725,0.409048002125613,"CEMIP","cell migration inducing hyaluronan binding protein",TRUE
+"222009_at",0.908264415710317,0.618948767534535,-0.504415862587103,-5.81651149165061,-0.250597648582831,"CEMP1","cementum protein 1",TRUE
+"227841_at",0.641326159307468,0.11179288039408,-1.65612109035198,-4.68539795031884,-1.05135152246799,"CEMP1///AMDHD2","cementum protein 1///amidohydrolase domain containing 2",TRUE
+"219082_at",0.88767000285873,0.552484098747143,-0.603225736901291,-5.76398766340338,-0.276836023034115,"CEMP1///AMDHD2","cementum protein 1///amidohydrolase domain containing 2",TRUE
+"219591_at",0.632949074657601,0.104031203300351,-1.69528332217836,-4.62914704872313,-0.453397568587892,"CEND1","cell cycle exit and neuronal differentiation 1",TRUE
+"210821_x_at",0.623667408398064,0.0949502840535507,1.74438577251239,-4.55722620157913,0.670610207214168,"CENPA","centromere protein A",TRUE
+"212437_at",0.717354643280305,0.193086536877938,-1.34231637580364,-5.09823846048699,-0.45462678679384,"CENPB","centromere protein B",TRUE
+"223728_at",0.878907265409251,0.532467701184433,-0.634163181455512,-5.74568042550213,-0.256263944616533,"CENPBD1","CENPB DNA-binding domain containing 1",TRUE
+"229171_at",0.880842449447422,0.53662689260312,0.627684213937229,-5.74958734740767,0.500632629245388,"CENPBD1","CENPB DNA-binding domain containing 1",TRUE
+"1552330_at",0.937623890519979,0.723512280281952,-0.358296899731526,-5.87734864063808,-0.216000934152301,"CENPBD1","CENPB DNA-binding domain containing 1",TRUE
+"218624_s_at",0.734551465704364,0.218814802070427,1.26556799562741,-5.18830189756777,0.791276255615278,"CENPBD1P1","CENPB DNA-binding domains containing 1 pseudogene 1",TRUE
+"230528_s_at",0.809821466472455,0.353255454510618,0.948200503703327,-5.51101097579763,0.546935154498904,"CENPBD1P1","CENPB DNA-binding domains containing 1 pseudogene 1",TRUE
+"222694_at",0.839519981963042,0.427996318377532,0.807440486568407,-5.62703082417132,0.390017781002188,"CENPBD1P1","CENPB DNA-binding domains containing 1 pseudogene 1",TRUE
+"204739_at",0.862634144901168,0.485877698193242,-0.708738313587187,-5.6979442763243,-0.226505115043693,"CENPC","centromere protein C",TRUE
+"205046_at",0.796378050779806,0.328924827363545,0.998273689030509,-5.46561809607607,0.39320422021231,"CENPE","centromere protein E",TRUE
+"207331_at",0.859919019023382,0.47819726701924,0.721416966856634,-5.68932538091082,0.668884765275292,"CENPF","centromere protein F",TRUE
+"209172_s_at",0.875187315707138,0.522253390178145,-0.650191991138969,-5.73584908847857,-0.316480438229453,"CENPF","centromere protein F",TRUE
+"207828_s_at",0.974821362145526,0.876599306652893,0.157086555826245,-5.92767176244971,0.0726035310227804,"CENPF","centromere protein F",TRUE
+"231772_x_at",0.881212599079924,0.537853826912411,0.625778129424751,-5.75072939520494,0.229944044063936,"CENPH","centromere protein H",TRUE
+"1563223_a_at",0.6181505942496,0.0891470953023885,1.77791260915841,-4.50724701310285,1.11039040568208,"CENPI","centromere protein I",TRUE
+"214804_at",0.785423378114,0.31085939756215,1.03713612760308,-5.4289285752717,0.352666744123312,"CENPI","centromere protein I",TRUE
+"207590_s_at",0.90343137006939,0.603640757214459,0.526692345234528,-5.80546559614988,0.166947416762065,"CENPI","centromere protein I",TRUE
+"1555046_at",0.935429186649424,0.712867773501209,0.372761925521182,-5.87223103554542,0.266455008944194,"CENPI","centromere protein I",TRUE
+"220885_s_at",0.854184492233394,0.464566226929001,-0.744215835548375,-5.67346162393887,-0.249257501307797,"CENPJ","centromere protein J",TRUE
+"223513_at",0.870460291516522,0.509209922294691,-0.670913305997299,-5.7227907525828,-0.25530257834806,"CENPJ","centromere protein J",TRUE
+"234023_s_at",0.932918358096654,0.703971107373853,-0.384914106536016,-5.86777727180971,-0.136443024891291,"CENPJ","centromere protein J",TRUE
+"222848_at",0.939676168830753,0.729449943002902,0.350262012269599,-5.8801049015397,0.138506126377234,"CENPK","centromere protein K",TRUE
+"232065_x_at",0.807084045192774,0.348340728184398,-0.958120882252374,-5.50218731835006,-0.309622066636553,"CENPL","centromere protein L",TRUE
+"1554271_a_at",0.94943075115007,0.77158991885899,-0.293873395838143,-5.89770726079323,-0.0841309820145195,"CENPL","centromere protein L",TRUE
+"218741_at",0.920169584950428,0.660365415101039,-0.445381261782758,-5.84352658431073,-0.240709309085577,"CENPM","centromere protein M",TRUE
+"234811_at",0.754155873045227,0.247454163007433,1.18789222492637,-5.2748156266178,0.601170183488178,"CENPN","centromere protein N",TRUE
+"228559_at",0.830635993561085,0.404196893400287,-0.850404288336139,-5.59345355817303,-0.304495793776672,"CENPN","centromere protein N",TRUE
+"222118_at",0.831182446031643,0.405303559311493,-0.848371465744255,-5.59507890160304,-0.321014955179692,"CENPN","centromere protein N",TRUE
+"219555_s_at",0.945498722604777,0.753581161871405,-0.317841734148642,-5.89059815327812,-0.158514371006513,"CENPN","centromere protein N",TRUE
+"226118_at",0.77204612088057,0.282376473968281,-1.10179384785548,-5.36510177838174,-0.390895104082045,"CENPO","centromere protein O",TRUE
+"219472_at",0.985392958586682,0.927611368237489,0.0918897757568464,-5.93557168741522,0.0247469271025782,"CENPO","centromere protein O",TRUE
+"219294_at",0.878278790222455,0.53103269762219,0.63640489557397,-5.7443196489877,0.223498506420503,"CENPQ","centromere protein Q",TRUE
+"226788_at",0.943345639021508,0.745837046049428,0.328206447766916,-5.8873530573953,0.104589863001698,"CENPT","centromere protein T",TRUE
+"218148_at",0.966313390701604,0.842987870495225,-0.200410274084314,-5.92013985423445,-0.0605138752466257,"CENPT","centromere protein T",TRUE
+"218883_s_at",0.636860247875294,0.107981455530114,-1.67505427742946,-4.65832758961514,-0.719623131277281,"CENPU","centromere protein U",TRUE
+"229304_s_at",0.776635428163387,0.294006403148163,-1.07485362564756,-5.39211520529926,-0.477258686860388,"CENPU","centromere protein U",TRUE
+"229305_at",0.829969884841107,0.40169479821976,-0.855013525948281,-5.58975481126964,-0.433662813600314,"CENPU","centromere protein U",TRUE
+"226610_at",0.497725944448536,0.030560656627089,2.31030627201432,-3.62862669912688,3.79390087569198,"CENPV","centromere protein V",TRUE
+"226611_s_at",0.545062800693621,0.0468449949786799,2.10508282825838,-3.98495440286998,2.73507913303693,"CENPV","centromere protein V",TRUE
+"230436_s_at",0.847093798440272,0.445760661615366,0.776333924553886,-5.65032089605345,0.338534424500495,"CENPV","centromere protein V",TRUE
+"236756_at",0.702630084418366,0.174195726883335,-1.40394998011058,-5.02270202107163,-0.705518672086283,"CENPVL2///CENPVL1","centromere protein V like 2///centromere protein V like 1",TRUE
+"226936_at",0.647754107214051,0.119088263294481,1.6213489047977,-4.73450068735262,0.73031275968675,"CENPW","centromere protein W",TRUE
+"243696_at",0.796466121438385,0.329263250406285,0.997560031303251,-5.46627998031273,0.640280490722062,"CEP104","centrosomal protein 104",TRUE
+"204074_s_at",0.858975609973555,0.475306544271419,0.726219628547333,-5.68602259889576,0.21050444826068,"CEP104","centrosomal protein 104",TRUE
+"204075_s_at",0.987487323337591,0.941061171824912,0.0747795486853875,-5.93696020001346,0.0237863892029448,"CEP104","centrosomal protein 104",TRUE
+"237960_at",0.697699759202153,0.168240441823665,1.42448140782012,-4.99691741082637,0.729591837886307,"CEP112","centrosomal protein 112",TRUE
+"213644_at",0.842435090181695,0.436325137334526,0.792759113749559,-5.63813032607136,0.796003685509807,"CEP112","centrosomal protein 112",TRUE
+"1557886_at",0.967098323798013,0.846337727503985,0.196076199816163,-5.92097524161157,0.164134031078465,"CEP112","centrosomal protein 112",TRUE
+"226449_at",0.820293495506061,0.379103964982952,-0.897495038284025,-5.55479088275222,-0.237298614681507,"CEP120","centrosomal protein 120",TRUE
+"1554606_at",0.843475287501313,0.438633200663311,-0.788721316094105,-5.64114941254653,-0.279661409836885,"CEP120","centrosomal protein 120",TRUE
+"232166_at",0.864894115958506,0.493635201377439,0.696049536844588,-5.70642424565605,0.727696908264276,"CEP126","centrosomal protein 126",TRUE
+"235956_at",0.903925276836898,0.605923390874665,0.523353726059234,-5.80715068911538,0.312331234614088,"CEP126","centrosomal protein 126",TRUE
+"236325_at",0.999503346640971,0.998747134774423,-0.00158804592039376,-5.93968225242962,-0.0013951985417,"CEP126","centrosomal protein 126",TRUE
+"233859_at",0.854116828440652,0.463580267718077,-0.745880179830163,-5.6722852165917,-0.450690505022852,"CEP128","centrosomal protein 128",TRUE
+"244033_at",0.871744769522775,0.513774528287323,0.663628650989146,-5.72742621312627,0.222549381035443,"CEP128","centrosomal protein 128",TRUE
+"1557756_a_at",0.872289159593181,0.515380503182407,0.66107425306162,-5.72904017527454,0.315840848183943,"CEP128","centrosomal protein 128",TRUE
+"1557755_at",0.908882763411412,0.621559585242743,0.500642544012447,-5.81833640333785,0.217964151999562,"CEP128","centrosomal protein 128",TRUE
+"232635_at",0.926430328514448,0.680349088341278,0.417474418905522,-5.85515041429117,0.156598561346116,"CEP128","centrosomal protein 128",TRUE
+"214742_at",0.919375181609246,0.657279929982037,0.449721725705684,-5.84165237027222,0.191265155033771,"CEP131","centrosomal protein 131",TRUE
+"206003_at",0.676294804179428,0.143034987881053,-1.51847768901836,-4.87499716951544,-0.467780133638183,"CEP135","centrosomal protein 135",TRUE
+"207286_at",0.996557570480389,0.982887370610973,-0.0216925622321323,-5.9394542873873,-0.0120364675363493,"CEP135","centrosomal protein 135",TRUE
+"239413_at",0.674438494582062,0.140856940337577,1.52721887565605,-4.86334159643093,0.490086487408067,"CEP152","centrosomal protein 152",TRUE
+"238535_at",0.892780783477555,0.566121806367935,-0.582483979216474,-5.77576654378816,-0.292648519342477,"CEP152","centrosomal protein 152",TRUE
+"237129_at",0.89547555116602,0.574627523647009,0.569677498453339,-5.78283995898098,0.238606214835668,"CEP152","centrosomal protein 152",TRUE
+"215882_at",0.909441642299191,0.623928645485883,0.497224993285676,-5.81997770925057,0.251576246645484,"CEP152","centrosomal protein 152",TRUE
+"215170_s_at",0.987024385896683,0.940105750707922,0.0759941758598467,-5.93687102668953,0.0335599895384036,"CEP152","centrosomal protein 152",TRUE
+"206005_s_at",0.501591596209182,0.0321469673586108,2.28639850982667,-3.67115971075529,1.23023586928365,"CEP162","centrosomal protein 162",TRUE
+"206006_s_at",0.655745626967443,0.124312819817422,1.5975282352743,-4.76767396652708,0.582684612499548,"CEP162","centrosomal protein 162",TRUE
+"204250_s_at",0.947778780715578,0.762410753473276,0.30606733782707,-5.89415947831734,0.0874054736221472,"CEP164","centrosomal protein 164",TRUE
+"1558953_s_at",0.957571530817866,0.808886866446343,-0.244770385148637,-5.91054434835872,-0.107613901473941,"CEP164","centrosomal protein 164",TRUE
+"204251_s_at",0.994825233837873,0.975824511405352,0.0306481894279924,-5.93922598709813,0.00946349405952063,"CEP164","centrosomal protein 164",TRUE
+"213242_x_at",0.993892931327222,0.971279389479531,-0.036412665284063,-5.93903771305151,-0.0131539412024182,"CEP170B","centrosomal protein 170B",TRUE
+"1552717_s_at",0.941106542715586,0.736003449441153,-0.341420940998383,-5.88306631793657,-0.159927833269858,"CEP170P1///CEP170","centrosomal protein 170 pseudogene 1///centrosomal protein 170",TRUE
+"207719_x_at",0.957390359236635,0.807055886126912,-0.247165652375938,-5.90997210200817,-0.126241563491869,"CEP170P1///CEP170","centrosomal protein 170 pseudogene 1///centrosomal protein 170",TRUE
+"212746_s_at",0.998047179825832,0.99120571792358,-0.0111472643998556,-5.9396229577334,-0.00667282007172254,"CEP170P1///CEP170","centrosomal protein 170 pseudogene 1///centrosomal protein 170",TRUE
+"230860_at",0.90344422113846,0.604293554460265,-0.52573693555994,-5.8059488833795,-0.235770303503036,"CEP19","centrosomal protein 19",TRUE
+"1553158_at",0.925821452712582,0.678935731989227,0.419436846938953,-5.85435717076791,0.251473570296755,"CEP19","centrosomal protein 19",TRUE
+"218827_s_at",0.369623435296638,0.0110952718482807,2.77117541127448,-2.76368479427191,1.04548677773259,"CEP192","centrosomal protein 192",TRUE
+"210894_s_at",0.840626658654418,0.42986887515901,0.804124371308604,-5.62955462530937,0.25268082966653,"CEP250","centrosomal protein 250",TRUE
+"209495_at",0.860085676417428,0.479138479883144,-0.719856895960468,-5.69039375518476,-0.35970535601734,"CEP250","centrosomal protein 250",TRUE
+"236424_at",0.861659105448003,0.483484595395766,-0.712676218895567,-5.69528287899176,-0.537630952489476,"CEP250","centrosomal protein 250",TRUE
+"1556850_at",0.506191505604384,0.0332276417670623,2.27072245099839,-3.69890721388878,1.36990009502772,"CEP290","centrosomal protein 290",TRUE
+"221683_s_at",0.859064198633089,0.475562797135815,0.725793198899179,-5.68631669641578,0.332379321733209,"CEP290","centrosomal protein 290",TRUE
+"205250_s_at",0.919354071504066,0.656420530177623,0.450932235086928,-5.84112649285872,0.201465221867579,"CEP290","centrosomal protein 290",TRUE
+"215018_at",0.821424121108148,0.38320497427952,0.889663005338742,-5.56135512791831,0.896846373147004,"CEP295","centrosomal protein 295",TRUE
+"1565829_at",0.866197674833253,0.497000224182789,-0.690581003361631,-5.71003381962175,-0.277228721144054,"CEP295","centrosomal protein 295",TRUE
+"1569302_at",0.873230718105642,0.517690543881382,0.65740772847431,-5.73134638900857,0.203187484525991,"CEP295","centrosomal protein 295",TRUE
+"229878_at",0.901781358899845,0.598851988540442,0.533716279442704,-5.80188637108198,0.244550069298716,"CEP295","centrosomal protein 295",TRUE
+"213165_at",0.839466826665106,0.425906614833651,-0.811151823700475,-5.62419466894837,-0.249950236804272,"CEP350","centrosomal protein 350",TRUE
+"213957_s_at",0.839781238235762,0.428607141343739,0.806357789438493,-5.62785590656655,0.252067805766599,"CEP350","centrosomal protein 350",TRUE
+"204373_s_at",0.963737076458538,0.8344702955845,-0.211448304988157,-5.91793013317444,-0.0689511179101654,"CEP350","centrosomal protein 350",TRUE
+"213956_at",0.999285337578942,0.997694270563323,0.00292258735422918,-5.93967932049203,0.00115286625767297,"CEP350","centrosomal protein 350",TRUE
+"1563997_at",0.62110896023334,0.0911705268977053,1.76601528173401,-4.52506266367403,1.07027239159295,"CEP41","centrosomal protein 41",TRUE
+"239322_at",0.695925610637694,0.166054787679549,1.43216288312448,-4.98719162341466,0.579548440874972,"CEP41","centrosomal protein 41",TRUE
+"225484_at",0.727768691018583,0.207968139523994,1.29702144413601,-5.15193513905524,0.619247422628584,"CEP41","centrosomal protein 41",TRUE
+"215637_at",0.731282152951273,0.214318923979315,1.27845603752734,-5.17349264148694,0.578076805428869,"CEP41","centrosomal protein 41",TRUE
+"225485_at",0.849517610674975,0.450676925238216,0.767859753145649,-5.65651616882658,0.411980476124926,"CEP41","centrosomal protein 41",TRUE
+"241166_at",0.921729477898827,0.666094478054653,0.43734489849735,-5.8469496051662,0.252598351876571,"CEP41","centrosomal protein 41",TRUE
+"228334_x_at",0.892571140407054,0.564846117203183,0.584413154700603,-5.77468780871444,0.270125516897647,"CEP44","centrosomal protein 44",TRUE
+"241426_at",0.904381089098038,0.607740901712907,-0.520699705267546,-5.80848280071946,-0.375119806666691,"CEP44","centrosomal protein 44",TRUE
+"231850_x_at",0.986720888319514,0.937943414341693,-0.0787435903526881,-5.93666387118804,-0.0388199245175009,"CEP44","centrosomal protein 44",TRUE
+"218542_at",0.731439835297956,0.21454959199935,1.27778975754462,-5.1742613823857,0.542596310254158,"CEP55","centrosomal protein 55",TRUE
+"209862_s_at",0.585036027492332,0.0656422295397686,1.93666541046358,-4.26137328553032,0.806405083714933,"CEP57","centrosomal protein 57",TRUE
+"203491_s_at",0.595936234743389,0.0724233066834781,1.88634917621001,-4.34090847187479,0.734642734078557,"CEP57","centrosomal protein 57",TRUE
+"203492_x_at",0.623667408398064,0.0950375386455717,1.74389523761978,-4.55795224262207,0.709768282568252,"CEP57","centrosomal protein 57",TRUE
+"203494_s_at",0.722937902375896,0.19948207357879,1.3225278920145,-5.12188869672872,0.520560710559055,"CEP57","centrosomal protein 57",TRUE
+"203493_s_at",0.838303520227789,0.423094392574822,0.816164338439666,-5.62034480396295,0.34651280809641,"CEP57","centrosomal protein 57",TRUE
+"232152_at",0.60921532501728,0.0815741270132877,1.82461292796163,-4.43647609459219,1.77051995245042,"CEP57L1","centrosomal protein 57 like 1",TRUE
+"1554019_s_at",0.863548047008085,0.488448615879094,0.704520285610399,-5.70077940805711,0.399718294393843,"CEP57L1","centrosomal protein 57 like 1",TRUE
+"243118_at",0.913627134030439,0.637687042289492,0.477493985923498,-5.82923885972474,0.317924982164786,"CEP57L1","centrosomal protein 57 like 1",TRUE
+"1560418_at",0.972749073687893,0.8680519426466,0.168071250878601,-5.925934306359,0.101355727229174,"CEP57L1","centrosomal protein 57 like 1",TRUE
+"222151_s_at",0.779660352445192,0.300884013472218,-1.05928019810342,-5.40745828782742,-0.324463107315369,"CEP63","centrosomal protein 63",TRUE
+"219242_at",0.841967750949524,0.434741943244565,-0.795536413856301,-5.63604530125664,-0.312363296932716,"CEP63","centrosomal protein 63",TRUE
+"233650_at",0.863408882018863,0.487844907805396,0.705509618198735,-5.70011587954692,0.299220656361502,"CEP63","centrosomal protein 63",TRUE
+"212677_s_at",0.697172073261335,0.167617514927316,1.42666247975396,-4.99416023407831,0.631319897962932,"CEP68","centrosomal protein 68",TRUE
+"212675_s_at",0.760237493549547,0.258439903261976,1.15989080304892,-5.30483382798803,0.424848855600411,"CEP68","centrosomal protein 68",TRUE
+"1559159_at",0.83633038614858,0.417811034926702,0.82563814731978,-5.61300774337538,0.474058198608893,"CEP68","centrosomal protein 68",TRUE
+"207971_s_at",0.883952384679702,0.542407438939971,0.618724226983694,-5.75492670473819,0.25352999898763,"CEP68","centrosomal protein 68",TRUE
+"239442_at",0.966641191718519,0.845054922173395,0.197735445974203,-5.92065757345196,0.18913111977147,"CEP68","centrosomal protein 68",TRUE
+"1554488_at",0.803111243433434,0.340854256425918,-0.973416879377559,-5.4884178495206,-0.358809749371687,"CEP70","centrosomal protein 70",TRUE
+"224150_s_at",0.813418501361393,0.363296923879108,0.928217646505926,-5.52852880905378,0.368215418248342,"CEP70","centrosomal protein 70",TRUE
+"219036_at",0.885029460971826,0.545658140327228,0.613707934707267,-5.75788366683287,0.221847630837186,"CEP70","centrosomal protein 70",TRUE
+"1554489_a_at",0.917102138198416,0.649532178419887,0.46065979479594,-5.83685027813375,0.161086155050118,"CEP70","centrosomal protein 70",TRUE
+"238154_at",0.94943075115007,0.771449793179203,0.294059197695851,-5.89765427526875,0.132879916714958,"CEP70","centrosomal protein 70",TRUE
+"219531_at",0.888312537451395,0.55432976202818,0.600403180877369,-5.76561394847569,0.375655634839491,"CEP72","centrosomal protein 72",TRUE
+"52285_f_at",0.345235484905341,0.00874336022683369,2.87561724777809,-2.55749004487371,1.1734926803053,"CEP76","centrosomal protein 76",TRUE
+"219311_at",0.40221114169538,0.0145167553335498,2.65177819746401,-2.99523727274225,1.21766282344305,"CEP76","centrosomal protein 76",TRUE
+"228774_at",0.912906062613339,0.634605671691192,-0.481896043588099,-5.82720442994443,-0.145915894181405,"CEP78","centrosomal protein 78",TRUE
+"1557985_s_at",0.992490513431419,0.965009291584877,0.0443670069468272,-5.93872477591395,0.0160123636868832,"CEP78","centrosomal protein 78",TRUE
+"235919_at",0.999127703490878,0.997190665784979,-0.00356092542302064,-5.93967730469802,-0.0015375133062836,"CEP78","centrosomal protein 78",TRUE
+"239282_at",0.943512938262733,0.747405777642999,0.326103932891106,-5.88801966884058,0.15558396279027,"CEP83","centrosomal protein 83",TRUE
+"219644_at",0.983212176432519,0.918197722664027,-0.1038818166603,-5.93442873868148,-0.0319604410250616,"CEP83","centrosomal protein 83",TRUE
+"237021_at",0.774230543658252,0.288156008738303,1.0883078571648,-5.37869891276363,0.374086834373878,"CEP83-AS1","CEP83 antisense RNA 1 (head to head)",TRUE
+"219611_s_at",0.72771207580435,0.207938651308484,1.29710866443632,-5.15183323868709,0.379315680501266,"CEP85","centrosomal protein 85",TRUE
+"227818_at",0.975657122206595,0.883986065764865,-0.147609383519671,-5.92907665990318,-0.0435045747537348,"CEP85","centrosomal protein 85",TRUE
+"228007_at",0.834428964025434,0.412597842568406,0.835060367898627,-5.60563204331864,0.863386161104343,"CEP85L","centrosomal protein 85 like",TRUE
+"232444_at",0.843257017684317,0.437745902949535,0.790272032433944,-5.63999164869713,0.561955707218792,"CEP85L","centrosomal protein 85 like",TRUE
+"1553732_s_at",0.588647704922709,0.0671810660724752,1.92485964398031,-4.28016500651107,0.55343665743214,"CEP89","centrosomal protein 89",TRUE
+"1554513_s_at",0.767727587789514,0.270032058545483,1.13128401461322,-5.33485129239457,0.369772045120103,"CEP89","centrosomal protein 89",TRUE
+"1560599_a_at",0.834654118013092,0.413204372589488,0.833960283628395,-5.60649722317643,0.283965614424281,"CEP89","centrosomal protein 89",TRUE
+"232106_s_at",0.888830748858811,0.556044802824585,-0.597784787061328,-5.76711601364422,-0.528661713092831,"CEP89","centrosomal protein 89",TRUE
+"1554512_a_at",0.94333312187812,0.745712841526077,0.3283729790093,-5.88730007673114,0.194132348954747,"CEP89","centrosomal protein 89",TRUE
+"1563919_a_at",0.95168059103032,0.778303727104122,0.284983348430989,-5.90020363467919,0.111474889199971,"CEP89","centrosomal protein 89",TRUE
+"223815_at",0.853297110808539,0.460046165424483,0.751863305534978,-5.66803560831899,0.448618190759157,"CEP95","centrosomal protein 95",TRUE
+"243206_at",0.894054364496985,0.570248886202165,0.576257963081125,-5.77922438569122,0.564419527415258,"CEP95","centrosomal protein 95",TRUE
+"225705_at",0.947969282616012,0.763539301690213,0.30456561447507,-5.89460411774049,0.105799751660506,"CEP95","centrosomal protein 95",TRUE
+"235918_x_at",0.971216837324271,0.863103331396263,-0.174440588117459,-5.92487324296063,-0.0738122200178992,"CEP97","centrosomal protein 97",TRUE
+"219886_at",0.984397001287044,0.923887068248978,0.0966324101686405,-5.93513639480063,0.0376138922233205,"CEP97","centrosomal protein 97",TRUE
+"241836_x_at",0.997890350692744,0.990200244931064,-0.0124218249387164,-5.93960832634256,-0.00462136083569398,"CEP97","centrosomal protein 97",TRUE
+"1558957_s_at",0.51470556386048,0.0351087770734118,-2.24451407741817,-3.74504442470182,-2.10894920198772,"CEPT1","choline/ethanolamine phosphotransferase 1",TRUE
+"236327_at",0.899808883319249,0.593539377217055,0.541540499812624,-5.79784503878664,0.524854480484953,"CEPT1","choline/ethanolamine phosphotransferase 1",TRUE
+"1561884_at",0.905800567127225,0.612167110304858,0.514252092050522,-5.81169151015357,0.210855843211794,"CEPT1","choline/ethanolamine phosphotransferase 1",TRUE
+"219375_at",0.925245959757418,0.676212223245481,-0.42322314228397,-5.85281635740656,-0.15289233107754,"CEPT1","choline/ethanolamine phosphotransferase 1",TRUE
+"221378_at",0.778800606399021,0.299754548899149,1.06182015581108,-5.40496958792132,0.252312438862045,"CER1","cerberus 1, DAN family BMP antagonist",TRUE
+"224794_s_at",0.88767000285873,0.552318153958436,0.603479756708897,-5.76384094243467,0.289588812280622,"CERCAM","cerebral endothelial cell adhesion molecule",TRUE
+"227381_at",0.966593471043185,0.844662043907883,-0.198243728267289,-5.9205597275352,-0.0921709989012411,"CERCAM","cerebral endothelial cell adhesion molecule",TRUE
+"218421_at",0.857316604145187,0.472581637555442,0.730762511098654,-5.68287930374043,0.2976496736868,"CERK","ceramide kinase",TRUE
+"206397_x_at",0.81031378318664,0.353997681958001,0.946710451838088,-5.5123290308309,0.894738713725703,"CERS1///GDF1","ceramide synthase 1///growth differentiation factor 1",TRUE
+"229448_at",0.84772210282622,0.447017392712991,0.774162316036518,-5.65191462499342,0.618061906006247,"CERS1///GDF1","ceramide synthase 1///growth differentiation factor 1",TRUE
+"222212_s_at",0.686108994812404,0.154611848689695,-1.47376343484928,-4.93378019547509,-0.755269236871754,"CERS2","ceramide synthase 2",TRUE
+"1554253_a_at",0.481616898681514,0.0273510831349996,2.36238169968922,-3.5351023112426,0.766532869748568,"CERS3","ceramide synthase 3",TRUE
+"1554252_a_at",0.870949414425649,0.510925130649991,0.668171746432527,-5.72454098353906,0.611802174235433,"CERS3","ceramide synthase 3",TRUE
+"218922_s_at",0.835513930382091,0.414855004158757,-0.830971641390699,-5.60884230717885,-1.2998489394884,"CERS4","ceramide synthase 4",TRUE
+"239491_at",0.460862664679766,0.0231126735537616,2.44055114829233,-3.39253189418903,1.82904947159126,"CERS5","ceramide synthase 5",TRUE
+"224951_at",0.993892931327222,0.971433121133545,-0.0362176713511463,-5.93904461063247,-0.0092004047345764,"CERS5","ceramide synthase 5",TRUE
+"242019_at",0.522688200326889,0.0386085875838406,-2.19898821903416,-3.82442024389892,-1.34611598073128,"CERS6","ceramide synthase 6",TRUE
+"235463_s_at",0.65284137151906,0.121948257730497,-1.60820343120579,-4.75285446885797,-1.00311637397622,"CERS6","ceramide synthase 6",TRUE
+"212446_s_at",0.68041487556515,0.148034990529903,-1.49881631936682,-4.90101842204949,-0.899419442630972,"CERS6","ceramide synthase 6",TRUE
+"212442_s_at",0.767965891104819,0.270979774870996,-1.12898549094781,-5.33723447588374,-0.748257525710105,"CERS6","ceramide synthase 6",TRUE
+"206824_at",0.813871363705431,0.364763378177925,-0.925330482580707,-5.53103146362038,-0.760641826855525,"CES1P1","carboxylesterase 1 pseudogene 1",TRUE
+"209667_at",0.556314028408939,0.0516377447494351,-2.05708848405291,-4.06527379926975,-0.876213974511145,"CES2","carboxylesterase 2",TRUE
+"213509_x_at",0.768852835478002,0.272787346893113,-1.12461780212374,-5.34175123350006,-0.358267984095066,"CES2","carboxylesterase 2",TRUE
+"209668_x_at",0.807944276806637,0.349451804602261,-0.955869913569449,-5.50419681086875,-0.346256351342104,"CES2","carboxylesterase 2",TRUE
+"220335_x_at",0.708473702007515,0.180561192793661,1.38261470947948,-5.04916864607728,0.864990890184376,"CES3","carboxylesterase 3",TRUE
+"234008_s_at",0.762225611287473,0.261648019890954,-1.15188073617699,-5.31330534879543,-0.681663458665041,"CES3","carboxylesterase 3",TRUE
+"228903_at",0.82706053436911,0.395747229008849,-0.866044355916487,-5.58082739236449,-0.766774493201655,"CES4A","carboxylesterase 4A",TRUE
+"1553465_a_at",0.974536463688956,0.875626338589602,0.158335948031327,-5.92748004734295,0.0977518664035886,"CES5A","carboxylesterase 5A",TRUE
+"207209_at",0.632216562924782,0.102999647793069,1.70067302854211,-4.62132782233878,1.16881158240223,"CETN1","centrin 1",TRUE
+"209194_at",0.787781415608703,0.313596047533241,-1.03114909610186,-5.43466330779678,-0.346971124443019,"CETN2","centrin 2",TRUE
+"209662_at",0.803583569469174,0.34208930852591,-0.970877794686231,-5.49071731925786,-0.368541726885466,"CETN3","centrin 3",TRUE
+"206210_s_at",0.990984475090957,0.95771518600161,-0.0536241493741256,-5.9382830037087,-0.0222569581621266,"CETP","cholesteryl ester transfer protein",TRUE
+"242615_at",0.552420073963858,0.050195153283137,2.07109930482389,-4.0419505165363,0.633525267481681,"CFAP100","cilia and flagella associated protein 100",TRUE
+"243758_at",0.983679139992471,0.920381819752169,-0.101098171113053,-5.93470651216219,-0.102592114825073,"CFAP100","cilia and flagella associated protein 100",TRUE
+"231077_at",0.976994788692278,0.890280937817018,0.139544041202812,-5.93020357293013,0.0726885579090526,"CFAP126","cilia and flagella associated protein 126",TRUE
+"1557867_s_at",0.782533011281359,0.304940984697954,1.05021237153514,-5.41629948442698,0.707018237470881,"CFAP157","cilia and flagella associated protein 157",TRUE
+"231172_at",0.937623890519979,0.723944075935312,0.35771178611037,-5.87755144073197,0.119452764132059,"CFAP157","cilia and flagella associated protein 157",TRUE
+"1557866_at",0.942534320272824,0.742563618577995,0.332598582473524,-5.88594683406246,0.124372264122042,"CFAP157","cilia and flagella associated protein 157",TRUE
+"1552950_at",0.65349309458318,0.122881801653583,1.60396833328494,-4.75874287777345,1.14570138626285,"CFAP161","cilia and flagella associated protein 161",TRUE
+"217957_at",0.95442332217412,0.79053121166729,0.268851906775332,-5.90453909392144,0.0796846541543399,"CFAP20","cilia and flagella associated protein 20",TRUE
+"230273_at",0.955904644595647,0.800646884469218,-0.255561588208291,-5.90792251863387,-0.22707707528873,"CFAP206","cilia and flagella associated protein 206",TRUE
+"243237_at",0.20044341474531,0.00223631427516487,-3.45523400482236,-1.36545572051685,-1.78477030691869,"CFAP221","cilia and flagella associated protein 221",TRUE
+"237151_s_at",0.657015752622694,0.125555843508543,1.59198414305668,-4.7753400846849,0.653625622240214,"CFAP221","cilia and flagella associated protein 221",TRUE
+"237152_at",0.954339677985638,0.789828448630089,-0.269777033303576,-5.90429723609034,-0.175278804593007,"CFAP221","cilia and flagella associated protein 221",TRUE
+"231043_at",0.982834147892409,0.916323195040065,0.106271583843497,-5.93418425708351,0.0266347247361907,"CFAP221","cilia and flagella associated protein 221",TRUE
+"224968_at",0.889389445320988,0.557217988130134,0.595996083034146,-5.7681384736158,0.22907984459332,"CFAP36","cilia and flagella associated protein 36",TRUE
+"243896_at",0.304021288441764,0.00587746688400447,3.04728142534645,-2.21204888622495,2.37139720401493,"CFAP43","cilia and flagella associated protein 43",TRUE
+"220919_s_at",0.755868740464627,0.250352874413198,1.18041518891884,-5.28289242207463,1.08767492692499,"CFAP43","cilia and flagella associated protein 43",TRUE
+"224251_at",0.826134344333512,0.393731275819025,0.869807542502274,-5.57775743906383,0.437378269934813,"CFAP43","cilia and flagella associated protein 43",TRUE
+"231084_at",0.96496567842849,0.837415482580247,0.207628631534672,-5.9187081463594,0.138920679933944,"CFAP43","cilia and flagella associated protein 43",TRUE
+"221103_s_at",0.535697382361465,0.0429458792455399,-2.14750295775203,-3.91297968160075,-0.732947496989417,"CFAP44","cilia and flagella associated protein 44",TRUE
+"230152_at",0.67606695078322,0.142576882144897,-1.52030709485989,-4.87256223431585,-0.569410452046404,"CFAP44","cilia and flagella associated protein 44",TRUE
+"220308_at",0.791646964605038,0.322304318243391,1.01233853304248,-5.45248603805737,0.619834819846083,"CFAP45","cilia and flagella associated protein 45",TRUE
+"1552964_at",0.771011793494937,0.279746995932163,1.1079956878905,-5.35879886763073,0.315635131614793,"CFAP46","cilia and flagella associated protein 46",TRUE
+"220539_at",0.815775199549376,0.366728560016132,-0.92147354674468,-5.53436353903588,-0.864822748550484,"CFAP46","cilia and flagella associated protein 46",TRUE
+"1555573_at",0.860026478479837,0.478595150150279,0.720757252533655,-5.6897774376351,0.797911702448376,"CFAP46","cilia and flagella associated protein 46",TRUE
+"1553466_at",0.797076936586489,0.330222745473042,0.995539430355274,-5.46815166198193,0.304493685053431,"CFAP47","cilia and flagella associated protein 47",TRUE
+"237755_s_at",0.876880701400693,0.525968040282318,-0.644343148262289,-5.73946382030168,-0.473319325502262,"CFAP52","cilia and flagella associated protein 52",TRUE
+"239916_at",0.940964444369914,0.735620746698162,0.341936460848072,-5.88289569366109,0.25156273145438,"CFAP52","cilia and flagella associated protein 52",TRUE
+"1552326_a_at",0.953460983789052,0.785456537189624,-0.275537715995801,-5.90277264787321,-0.192189719245047,"CFAP53","cilia and flagella associated protein 53",TRUE
+"1552325_at",0.998870448604467,0.996167172533786,0.00485824671920994,-5.93967198481831,0.0037103096961717,"CFAP53","cilia and flagella associated protein 53",TRUE
+"1560426_at",0.540713063686847,0.0450789919820953,2.12388567962252,-3.95316372689931,0.724763883282658,"CFAP54","cilia and flagella associated protein 54",TRUE
+"1553425_at",0.692529423238777,0.16203162374755,1.44651743838576,-4.96890228540308,0.910732200409527,"CFAP57","cilia and flagella associated protein 57",TRUE
+"233131_at",0.903906029494077,0.605530972961576,-0.523927253693847,-5.80686195623304,-0.375445369504451,"CFAP58","cilia and flagella associated protein 58",TRUE
+"1557544_at",0.976140471115891,0.885282458499141,0.145947570650952,-5.92931402068708,0.118241737552662,"CFAP58","cilia and flagella associated protein 58",TRUE
+"233389_at",0.419258213999957,0.0172304529138163,2.57468092904047,-3.1421764021153,0.954407019708131,"CFAP61","cilia and flagella associated protein 61",TRUE
+"1554657_a_at",0.817916967564753,0.371013419525806,0.913111393733441,-5.5415437055043,0.798794472373192,"CFAP61","cilia and flagella associated protein 61",TRUE
+"240453_at",0.91101836045758,0.628756796193265,0.49027850075106,-5.82327997685107,0.443293069440839,"CFAP61","cilia and flagella associated protein 61",TRUE
+"1553886_at",0.54295328972902,0.0461460654482874,2.11244689037531,-3.97252517704521,0.997540982135766,"CFAP65","cilia and flagella associated protein 65",TRUE
+"1556969_at",0.675622576285316,0.141929599634403,1.52290019938828,-4.86910681540339,0.944996465684464,"CFAP65","cilia and flagella associated protein 65",TRUE
+"239508_x_at",0.7717895132349,0.281578574127102,1.10367131680755,-5.36319702905019,0.309565080824823,"CFAP65","cilia and flagella associated protein 65",TRUE
+"1564872_at",0.529522722988603,0.0413104088602193,2.16633894739868,-3.8807311561607,1.69569536972899,"CFAP69","cilia and flagella associated protein 69",TRUE
+"1554919_s_at",0.774230543658252,0.289479867947783,1.08524628384039,-5.38176493944128,0.835064522326582,"CFAP69","cilia and flagella associated protein 69",TRUE
+"219455_at",0.925511384407886,0.677977504948489,0.420768286367858,-5.8538169000351,0.257337422338982,"CFAP69","cilia and flagella associated protein 69",TRUE
+"215849_x_at",0.771011793494937,0.27966598323168,1.10818743366325,-5.35860349644464,0.919197212700403,"CFAP70","cilia and flagella associated protein 70",TRUE
+"229169_at",0.847413923177692,0.446095428201195,-0.775755090309326,-5.65074611034293,-0.599711742870011,"CFAP70","cilia and flagella associated protein 70",TRUE
+"229170_s_at",0.986421906591669,0.936618258521514,-0.0804288343372786,-5.93653325912479,-0.0669401801628506,"CFAP70","cilia and flagella associated protein 70",TRUE
+"226539_s_at",0.683017520100356,0.151197220854568,1.48665989029589,-4.91697097315564,0.62670157204327,"CFAP73","cilia and flagella associated protein 73",TRUE
+"226540_at",0.979588787486838,0.902388413814904,0.124057393051426,-5.93219024281252,0.0579543183430031,"CFAP73","cilia and flagella associated protein 73",TRUE
+"215788_at",0.622670118615498,0.093192676371845,1.75434998592289,-4.54244550623051,0.98928680544323,"CFAP74","cilia and flagella associated protein 74",TRUE
+"216807_at",0.718706241731185,0.194764280047944,1.33707616348829,-5.10453003907306,0.744586884193623,"CFAP74","cilia and flagella associated protein 74",TRUE
+"216781_at",0.96440836428144,0.835979332725278,0.209490805429566,-5.91833061221997,0.146865690932123,"CFAP74","cilia and flagella associated protein 74",TRUE
+"230569_at",0.841206569659492,0.431128192829769,0.801899284233585,-5.63124260616766,0.358118934849904,"CFAP97","cilia and flagella associated protein 97",TRUE
+"230567_at",0.867692227847244,0.500561377288888,-0.684816653491666,-5.71380921159831,-0.510091651671961,"CFAP97","cilia and flagella associated protein 97",TRUE
+"1554550_at",0.916004518608805,0.645383192791008,0.466540679371569,-5.83422168827441,0.392413372579646,"CFAP97","cilia and flagella associated protein 97",TRUE
+"226254_s_at",0.951135659117732,0.776741600882919,-0.287049708862887,-5.89963017484869,-0.150528516414848,"CFAP97","cilia and flagella associated protein 97",TRUE
+"1569172_a_at",0.833697699504478,0.411290865088876,-0.837434365668164,-5.60376134061537,-0.34144633856576,"CFAP99","cilia and flagella associated protein 99",TRUE
+"202357_s_at",0.654592482818544,0.123516178667363,1.60110573027757,-4.76271616524814,1.53504659677897,"CFB","complement factor B",TRUE
+"211920_at",0.932415412515157,0.701764394831136,-0.387937395545713,-5.86664735873643,-0.271061929625857,"CFB","complement factor B",TRUE
+"236724_at",0.64899483340772,0.119804386896829,-1.61803278434749,-4.73914156780648,-1.11183401411436,"CFC1","cripto, FRL-1, cryptic family 1",TRUE
+"223752_at",0.952697366942815,0.783506508506226,0.27811024905925,-5.90208148818505,0.179070899045776,"CFC1","cripto, FRL-1, cryptic family 1",TRUE
+"228878_s_at",0.757479140651,0.253670655058433,1.17193606131209,-5.29199778057911,0.898404926115041,"CFC1B","cripto, FRL-1, cryptic family 1B",TRUE
+"223753_s_at",0.594972224548427,0.0716712375129561,-1.8917207894226,-4.33248713410548,-1.30708324797609,"CFC1B///CFC1","cripto, FRL-1, cryptic family 1B///cripto, FRL-1, cryptic family 1",TRUE
+"205382_s_at",0.686025661550069,0.154253660313459,-1.47510532037684,-4.93203669443489,-1.24156603530898,"CFD","complement factor D",TRUE
+"203166_at",0.640067422642767,0.110729421915994,-1.66134829998116,-4.67794757593224,-0.586709814873458,"CFDP1","craniofacial development protein 1",TRUE
+"210701_at",0.921716759218618,0.665910544540472,0.437602451638362,-5.84684085146203,0.281778729707582,"CFDP1","craniofacial development protein 1",TRUE
+"236588_at",0.998709719538178,0.994114595799613,0.00746000322759707,-5.93965637491949,0.00241678009415391,"CFDP1","craniofacial development protein 1",TRUE
+"213800_at",0.517348414110187,0.0365557914786016,2.22521155683633,-3.77881922703433,2.68349995655988,"CFH","complement factor H",TRUE
+"215388_s_at",0.729041056651108,0.210489287019538,1.28959955060988,-5.16058489385362,1.5855037857999,"CFHR1///CFH","complement factor H related 1///complement factor H",TRUE
+"206910_x_at",0.597654932724127,0.0747982716825606,1.8697004689967,-4.36690244549461,0.668869879148002,"CFHR2","complement factor H related 2",TRUE
+"1570228_at",0.910860516303107,0.628061734360662,0.491277005751653,-5.82280809414086,0.407161852939272,"CFHR3","complement factor H related 3",TRUE
+"1554459_s_at",0.982909728377256,0.91723700197803,-0.105106526252233,-5.93430414043833,-0.0900519364158874,"CFHR3","complement factor H related 3",TRUE
+"207874_s_at",0.795497760925102,0.327658268219554,1.00094910063809,-5.4631329524313,0.928776674039959,"CFHR4","complement factor H related 4",TRUE
+"208088_s_at",0.879423777614825,0.533717501640763,-0.632213447470563,-5.74686020706973,-0.269291435732632,"CFHR5","complement factor H related 5",TRUE
+"203854_at",0.849646596450765,0.450904685982272,0.767468523392127,-5.65680063738062,1.15276117750893,"CFI","complement factor I",TRUE
+"1555564_a_at",0.9116561917482,0.630088028868165,0.488367500716716,-5.82418047911535,0.86798525159119,"CFI","complement factor I",TRUE
+"236792_at",0.697412165374288,0.167805399220926,1.42600395095868,-4.99499306992844,0.866758907547178,"CFL1","cofilin 1",TRUE
+"1555730_a_at",0.888756025960104,0.55554699592694,-0.59854436586426,-5.76668092739997,-0.159309678252651,"CFL1","cofilin 1",TRUE
+"200021_at",0.923708852928185,0.672279690291307,-0.428701392999006,-5.85056292473155,-0.0946767427613935,"CFL1","cofilin 1",TRUE
+"230870_at",0.943824539742785,0.748566162790016,-0.324549674894983,-5.88850972708659,-0.169714441017587,"CFL1","cofilin 1",TRUE
+"224352_s_at",0.877861946695164,0.529266657415722,0.639168258398344,-5.74263586512096,0.741753405104898,"CFL2","cofilin 2",TRUE
+"224663_s_at",0.88698237223329,0.550927019163852,0.60561081261043,-5.76260770336985,0.74458594842646,"CFL2","cofilin 2",TRUE
+"233496_s_at",0.901704668741384,0.598580172875511,0.53411577826128,-5.80168140956361,0.563994577425612,"CFL2","cofilin 2",TRUE
+"214486_x_at",0.595019326272843,0.0718272583192272,1.89060237774884,-4.33424190531948,0.810218909587647,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"211316_x_at",0.640337040581689,0.111088479925353,1.65957870849164,-4.68047178943808,0.650325880705587,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"208485_x_at",0.640337040581689,0.111120587404587,1.65942070421323,-4.68069707314126,0.747226782068106,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"211862_x_at",0.651040858265466,0.120795126704465,1.61347225438816,-4.74551199096733,0.698285934414402,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"209508_x_at",0.704136697708699,0.175998758315264,1.39784454499025,-5.03031009153221,0.642547876244153,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"211317_s_at",0.747487330197396,0.239291645915775,1.20930563685918,-5.25143911000709,0.632043914545212,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"239629_at",0.817857130700434,0.370618599006936,0.913879216409875,-5.54088693038516,0.688338341189956,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"217654_at",0.827866702343255,0.397335482414101,0.863088267638707,-5.58323024514442,0.51118341151678,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"210564_x_at",0.837839105061376,0.422538041738685,0.817158446301136,-5.61957863622678,0.400364438809508,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"210563_x_at",0.947926063538122,0.76299895080683,0.30528455286291,-5.89439152050903,0.146404698866158,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"235427_at",0.948429371744093,0.765128291024185,-0.302452407018399,-5.89522613788157,-0.148473857996558,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"214618_at",0.96736559784358,0.847265411686063,-0.194876636642627,-5.92120324092145,-0.106244410354179,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"209939_x_at",0.975449397348071,0.882723920227591,-0.149227704744074,-5.92884293378539,-0.0822749299548278,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"237367_x_at",0.984132887597385,0.922233585139104,-0.0987387261939834,-5.93493605397521,-0.0684804780375146,"CFLAR","CASP8 and FADD like apoptosis regulator",TRUE
+"1556924_at",0.680708651141727,0.148679486475325,1.49632164507674,-4.9043006253609,0.860387193029199,"CFLAR-AS1","CFLAR antisense RNA 1",TRUE
+"206380_s_at",0.927395026557689,0.68206070056213,-0.415100095406832,-5.85610526172801,-0.1931960124588,"CFP","complement factor properdin",TRUE
+"217026_at",0.51470556386048,0.0352465481277608,2.24264535637052,-3.74832190380032,1.295274946257,"CFTR","cystic fibrosis transmembrane conductance regulator",TRUE
+"234706_x_at",0.64513208805899,0.116341782805497,1.63422388036334,-4.71641288021286,1.49604663701989,"CFTR","cystic fibrosis transmembrane conductance regulator",TRUE
+"215702_s_at",0.792436690618566,0.32393114160464,1.00886396677528,-5.45574565547839,0.723013821917553,"CFTR","cystic fibrosis transmembrane conductance regulator",TRUE
+"234702_x_at",0.844029183111344,0.440349287525891,-0.785727594466102,-5.64337846529529,-0.657442644813923,"CFTR","cystic fibrosis transmembrane conductance regulator",TRUE
+"205043_at",0.879716812354048,0.534399877841443,-0.631149956740804,-5.74750225078276,-0.224042540318147,"CFTR","cystic fibrosis transmembrane conductance regulator",TRUE
+"215703_at",0.90427866743639,0.606887193603264,0.521945860049428,-5.80785814966028,0.425181396635723,"CFTR","cystic fibrosis transmembrane conductance regulator",TRUE
+"233615_at",0.937409179150458,0.722253861405324,0.360002874394099,-5.87675548202313,0.311257504402774,"CGA","glycoprotein hormones, alpha polypeptide",TRUE
+"204637_at",0.972405051071295,0.866983585672326,-0.169445717268856,-5.9257086647474,-0.17043455625659,"CGA","glycoprotein hormones, alpha polypeptide",TRUE
+"205387_s_at",0.00903542147780287,3.96616580644296e-06,6.07554686717753,4.17217088528095,4.0402270721075,"CGB1///CGB8///CGB7///CGB5///CGB3","chorionic gonadotropin beta subunit 1///chorionic gonadotropin beta subunit 8///chorionic gonadotropin beta subunit 7///chorionic gonadotropin beta subunit 5///chorionic gonadotropin beta subunit 3",TRUE
+"214471_x_at",0.936545227322061,0.71672474442816,0.367511413216838,-5.87411173507596,0.308283083346824,"CGB1///LHB","chorionic gonadotropin beta subunit 1///luteinizing hormone beta polypeptide",TRUE
+"231785_at",0.797960028258877,0.331960073698946,0.99189110001213,-5.47152237567922,1.13959165363164,"CGB7///NTF4","chorionic gonadotropin beta subunit 7///neurotrophin 4",TRUE
+"224599_at",0.738414578418269,0.225257361710679,-1.24744912490549,-5.20890438034588,-0.478212641485108,"CGGBP1","CGG triplet repeat binding protein 1",TRUE
+"224600_at",0.772153322615079,0.282522674328572,-1.10145025339404,-5.36545005345085,-0.39375510321187,"CGGBP1","CGG triplet repeat binding protein 1",TRUE
+"214050_at",0.827768017240356,0.396699447968564,0.864271150689857,-5.58226965725625,0.516250952761949,"CGGBP1","CGG triplet repeat binding protein 1",TRUE
+"206861_s_at",0.91671872326659,0.647609852051325,0.463382489344649,-5.83563737043176,0.140548083366028,"CGGBP1","CGG triplet repeat binding protein 1",TRUE
+"223232_s_at",0.922053973995699,0.667313168768352,0.435639183421499,-5.84766826918117,0.42302938214809,"CGN","cingulin",TRUE
+"223233_s_at",0.937735933140623,0.724437585633576,0.357043201388377,-5.87778277109055,0.212683309255494,"CGN","cingulin",TRUE
+"205937_at",0.982021726491165,0.91381102362698,-0.1094752569435,-5.93384779640535,-0.137134120108944,"CGREF1","cell growth regulator with EF-hand domain 1",TRUE
+"204605_at",0.690381347688918,0.160183214242345,-1.45320902965749,-4.96032564766028,-0.464180545186919,"CGRRF1","cell growth regulator with ring finger domain 1",TRUE
+"1558685_a_at",0.431769566611896,0.0192055525560152,-2.52542988990062,-3.2349097981615,-1.13698094202175,"CH17-340M24.3","uncharacterized protein BC009467",TRUE
+"210956_at",0.509447491563159,0.0338931164447628,2.26129952946101,-3.71553199465124,1.44455776198504,"CH17-360D5.1///NPY4R","neuropeptide Y receptor type 4-like///neuropeptide Y receptor Y4",TRUE
+"1556235_at",0.142607803108174,0.000955092831518632,3.80700502532896,-0.616057900926884,1.49308474710347,"CH17-408M7.1///LOC101929257///LOC101927468","uncharacterized LOC102724558///uncharacterized LOC101929257///uncharacterized LOC101927468",TRUE
+"206932_at",0.156653457988943,0.00120624834686498,3.7109483744926,-0.821901382261983,1.53066940022038,"CH25H","cholesterol 25-hydroxylase",TRUE
+"219270_at",0.976330538523238,0.885601016312139,0.145539284080692,-5.92937192686382,0.0705499625917909,"CHAC1","ChaC glutathione specific gamma-glutamylcyclotransferase 1",TRUE
+"235117_at",0.707898177720919,0.179748468304587,1.3853050911756,-5.04584968820026,0.717251383263857,"CHAC2","ChaC cation transport regulator homolog 2",TRUE
+"206869_at",0.878114621305798,0.530064836974422,-0.63791870979792,-5.74339811408037,-0.706845534282655,"CHAD","chondroadherin",TRUE
+"1557123_a_at",0.592111379991983,0.0692619802605261,1.90926765970486,-4.30486152521788,0.632176088019027,"CHADL","chondroadherin like",TRUE
+"214426_x_at",0.861763798017736,0.484078324204163,-0.711698173197193,-5.69594519296932,-0.252569629284723,"CHAF1A","chromatin assembly factor 1 subunit A",TRUE
+"203976_s_at",0.897949253801113,0.585698380523124,-0.55315141929387,-5.79174248700571,-0.215795227347479,"CHAF1A","chromatin assembly factor 1 subunit A",TRUE
+"229808_at",0.947326616179611,0.760436218354174,-0.308696520411545,-5.89337579525575,-0.242858562710841,"CHAF1A","chromatin assembly factor 1 subunit A",TRUE
+"203975_s_at",0.968431926687672,0.851511594761466,-0.189389716884038,-5.92222835911458,-0.0683164631027164,"CHAF1A","chromatin assembly factor 1 subunit A",TRUE
+"204775_at",0.954577684533304,0.792450482105767,0.266326572012295,-5.90519509753992,0.105741193067551,"CHAF1B","chromatin assembly factor 1 subunit B",TRUE
+"226194_at",0.639705117673934,0.110222501605247,1.66385488138321,-4.67436858576335,0.743152451634998,"CHAMP1","chromosome alignment maintaining phosphoprotein 1",TRUE
+"221197_s_at",0.830635993561085,0.404463547291434,-0.849914149652972,-5.59384578043871,-0.642958843433072,"CHAT","choline O-acetyltransferase",TRUE
+"226896_at",0.957571530817866,0.80944794364423,-0.244036684022074,-5.91071852629071,-0.0963299835390163,"CHCHD1","coiled-coil-helix-coiled-coil-helix domain containing 1",TRUE
+"224932_at",0.647754107214051,0.119115414242643,-1.62122287405002,-4.73467720035318,-0.952799444741022,"CHCHD10","coiled-coil-helix-coiled-coil-helix domain containing 10",TRUE
+"217720_at",0.993615552413264,0.969996134323669,0.0380404091825837,-5.9389786895532,0.00825039076335798,"CHCHD2","coiled-coil-helix-coiled-coil-helix domain containing 2",TRUE
+"217972_at",0.769258076576208,0.275679746475699,-1.11767261220354,-5.34890156433114,-0.371582401071478,"CHCHD3","coiled-coil-helix-coiled-coil-helix domain containing 3",TRUE
+"241164_at",0.941400961503247,0.738010003443608,0.338719551417227,-5.88395624862278,0.152891558588404,"CHCHD3","coiled-coil-helix-coiled-coil-helix domain containing 3",TRUE
+"229595_at",0.774230543658252,0.290175075138898,-1.08364257402606,-5.38336790760475,-0.390352159553618,"CHCHD4","coiled-coil-helix-coiled-coil-helix domain containing 4",TRUE
+"1562892_at",0.773107052530371,0.283801161953823,1.09845107430298,-5.36848598827678,0.336735303603402,"CHCHD5","coiled-coil-helix-coiled-coil-helix domain containing 5",TRUE
+"223479_s_at",0.79943091106207,0.334273127911502,-0.987054171172521,-5.47597389509285,-0.358101854365838,"CHCHD5","coiled-coil-helix-coiled-coil-helix domain containing 5",TRUE
+"237993_at",0.896229101808264,0.580148349628896,0.561416506784386,-5.78732189510514,0.276380019173305,"CHCHD5","coiled-coil-helix-coiled-coil-helix domain containing 5",TRUE
+"224462_s_at",0.69866353626144,0.169933926543965,-1.41858452433453,-5.00435456119446,-0.514658257114458,"CHCHD6","coiled-coil-helix-coiled-coil-helix domain containing 6",TRUE
+"222701_s_at",0.744573608322482,0.235759868719542,1.21874154251687,-5.2410231663562,0.612339640860116,"CHCHD7","coiled-coil-helix-coiled-coil-helix domain containing 7",TRUE
+"218642_s_at",0.801086839730802,0.337194782559638,0.980977417474154,-5.48153837937443,0.540010603626147,"CHCHD7","coiled-coil-helix-coiled-coil-helix domain containing 7",TRUE
+"204258_at",0.807051198331174,0.348216406790859,-0.958373052461434,-5.50196193073561,-0.29135507537991,"CHD1","chromodomain helicase DNA binding protein 1",TRUE
+"235791_x_at",0.864829185767069,0.492747415082612,-0.697495837298266,-5.70546505376435,-0.203051187466709,"CHD1","chromodomain helicase DNA binding protein 1",TRUE
+"238070_at",0.819018525257656,0.37428411448913,0.90677147300286,-5.54694723529272,0.356814359216656,"CHD1L","chromodomain helicase DNA binding protein 1 like",TRUE
+"207645_s_at",0.879423810379705,0.533734253311929,0.632187331022653,-5.74687598637837,0.24450289028516,"CHD1L","chromodomain helicase DNA binding protein 1 like",TRUE
+"1556988_s_at",0.908535021486648,0.619625035662054,0.503437767020234,-5.8169858174742,0.148596253463845,"CHD1L","chromodomain helicase DNA binding protein 1 like",TRUE
+"244848_at",0.918775990454959,0.655183485904863,0.452675879146532,-5.84036657143244,0.367419717050299,"CHD1L","chromodomain helicase DNA binding protein 1 like",TRUE
+"212539_at",0.943631120237335,0.747927943806455,0.325404425202915,-5.88824051072478,0.103170032094532,"CHD1L","chromodomain helicase DNA binding protein 1 like",TRUE
+"225077_at",0.825277018878999,0.39269959096949,-0.871738215194186,-5.57617762293776,-0.258097657353581,"CHD2","chromodomain helicase DNA binding protein 2",TRUE
+"1554014_at",0.837609393049242,0.42171433146605,-0.818631788131038,-5.6184415107101,-0.313981666951072,"CHD2","chromodomain helicase DNA binding protein 2",TRUE
+"203461_at",0.870980161749509,0.511256196044311,0.667643169694195,-5.72487764143751,0.219273110706337,"CHD2","chromodomain helicase DNA binding protein 2",TRUE
+"228999_at",0.927461627729509,0.682214394714807,-0.414887012018373,-5.856190692494,-0.194768911521995,"CHD2","chromodomain helicase DNA binding protein 2",TRUE
+"243751_at",0.965023008062487,0.837597144811696,-0.207393134081797,-5.91875565162951,-0.107350290017803,"CHD2","chromodomain helicase DNA binding protein 2",TRUE
+"1554015_a_at",0.976371465776674,0.886690444961182,0.144143185074912,-5.92956870857261,0.0376246536263487,"CHD2","chromodomain helicase DNA binding protein 2",TRUE
+"208806_at",0.811844013927892,0.356023482797422,-0.942654278132042,-5.51590736962058,-0.489231306654148,"CHD3","chromodomain helicase DNA binding protein 3",TRUE
+"208807_s_at",0.912041701968169,0.631467825933597,-0.48638873018471,-5.82510929429784,-0.199939066844301,"CHD3","chromodomain helicase DNA binding protein 3",TRUE
+"201184_s_at",0.959131001044522,0.81470437952464,-0.23716961276548,-5.91232353563826,-0.066995774479345,"CHD4","chromodomain helicase DNA binding protein 4",TRUE
+"201182_s_at",0.990623482682449,0.952669980483455,0.0600299140036152,-5.93792845705375,0.0257781303778,"CHD4","chromodomain helicase DNA binding protein 4",TRUE
+"201183_s_at",0.991215113882097,0.958728051658912,0.0523384264322037,-5.93834935148821,0.0174269144309651,"CHD4","chromodomain helicase DNA binding protein 4",TRUE
+"217250_s_at",0.778295711796067,0.297903439435293,-1.06599775588141,-5.40086467882412,-0.881172591129965,"CHD5","chromodomain helicase DNA binding protein 5",TRUE
+"213965_s_at",0.985361089461736,0.927491300663597,-0.0920426391003581,-5.9355579984736,-0.085905773786461,"CHD5","chromodomain helicase DNA binding protein 5",TRUE
+"225031_at",0.859502367311367,0.477315563350746,-0.722880028789001,-5.6883214423626,-0.282123752658574,"CHD6","chromodomain helicase DNA binding protein 6",TRUE
+"225026_at",0.873968636108443,0.519808263833456,-0.654054400305665,-5.7334448333257,-0.268231933588694,"CHD6","chromodomain helicase DNA binding protein 6",TRUE
+"234681_s_at",0.968451827985008,0.852073809999809,-0.188663671631101,-5.92236182021452,-0.0790890712887631,"CHD6","chromodomain helicase DNA binding protein 6",TRUE
+"1555463_a_at",0.974536463688956,0.87545000665406,0.158562404140668,-5.92744513620374,0.123408633057682,"CHD6","chromodomain helicase DNA binding protein 6",TRUE
+"226123_at",0.938726197187622,0.726842271250032,0.353787806701723,-5.87890302912621,0.17338569575791,"CHD7","chromodomain helicase DNA binding protein 7",TRUE
+"220619_at",0.943824539742785,0.748517130614884,0.324615333674954,-5.88848907172735,0.230378454614614,"CHD7","chromodomain helicase DNA binding protein 7",TRUE
+"222755_s_at",0.966593471043185,0.844397461104464,0.198586059703538,-5.92049368664706,0.156235449322139,"CHD7","chromodomain helicase DNA binding protein 7",TRUE
+"218829_s_at",0.998281568576251,0.991799813535655,-0.0103941842614159,-5.93963085904018,-0.00522445884180733,"CHD7","chromodomain helicase DNA binding protein 7",TRUE
+"212571_at",0.937757781799543,0.724524443792653,-0.356925547035029,-5.8778234352726,-0.111274901615545,"CHD8","chromodomain helicase DNA binding protein 8",TRUE
+"212615_at",0.645213368083975,0.116428212770711,-1.63381484727827,-4.71698921621653,-0.677003353515348,"CHD9","chromodomain helicase DNA binding protein 9",TRUE
+"212616_at",0.762252900774908,0.261732198542026,-1.15167153787705,-5.31352590779008,-0.47798830223333,"CHD9","chromodomain helicase DNA binding protein 9",TRUE
+"235388_at",0.794426378358553,0.326261875530014,-1.00390709344175,-5.460378300114,-0.630810357734489,"CHD9","chromodomain helicase DNA binding protein 9",TRUE
+"229586_at",0.819018525257656,0.374934143102719,-0.905515827417354,-5.54801330129503,-0.370221096633456,"CHD9","chromodomain helicase DNA binding protein 9",TRUE
+"242157_at",0.841391443291102,0.431956847353232,0.800437332679026,-5.63234926965823,0.253363498318532,"CHD9","chromodomain helicase DNA binding protein 9",TRUE
+"220586_at",0.886442673707182,0.549326944134371,-0.608065442824562,-5.76118201281912,-0.409590562502662,"CHD9","chromodomain helicase DNA binding protein 9",TRUE
+"239654_at",0.974451535839172,0.875110581688001,-0.158998338067836,-5.92737779121591,-0.0661108811591298,"CHD9","chromodomain helicase DNA binding protein 9",TRUE
+"1559590_at",0.462926905857638,0.0235014060205214,-2.43285150708225,-3.4066879023382,-2.55042847316876,"CHDH","choline dehydrogenase",TRUE
+"228560_at",0.496742810480539,0.030356604745548,-2.31346377970747,-3.62299012867352,-2.29492577570359,"CHDH","choline dehydrogenase",TRUE
+"229502_at",0.612420348961838,0.0842966602066985,-1.80740831254894,-4.46270299677525,-1.0106191956492,"CHDH","choline dehydrogenase",TRUE
+"229954_at",0.692573415624882,0.162100813895777,-1.44626815547644,-4.96922116949048,-0.716210550949138,"CHDH","choline dehydrogenase",TRUE
+"231994_at",0.756068287704519,0.250930318220141,-1.17893344150795,-5.28448774040259,-0.968238227871192,"CHDH","choline dehydrogenase",TRUE
+"1559591_s_at",0.8111749793648,0.355228924118014,-0.944243328337256,-5.51450719530507,-0.436047291302499,"CHDH","choline dehydrogenase",TRUE
+"230484_at",0.839466826665106,0.425402902546159,0.812048119343934,-5.62350790192382,0.233601827044124,"CHDH","choline dehydrogenase",TRUE
+"229423_at",0.304824368772306,0.00595619243346396,-3.04157505231319,-2.22365101253831,-3.06930071298968,"CHEK1","checkpoint kinase 1",TRUE
+"205393_s_at",0.913627134030439,0.637715325517693,0.477453624829324,-5.82925742829346,0.181112193289332,"CHEK1","checkpoint kinase 1",TRUE
+"205394_at",0.918409982899324,0.653666967338256,0.454815395971856,-5.83943019084098,0.175040697943011,"CHEK1","checkpoint kinase 1",TRUE
+"238075_at",0.932830928398943,0.703752575422773,0.385213341143817,-5.86766582551356,0.146137513070299,"CHEK1","checkpoint kinase 1",TRUE
+"210416_s_at",0.966561892743893,0.843910133178418,-0.199216654320271,-5.92037173832804,-0.0741969009224448,"CHEK2","checkpoint kinase 2",TRUE
+"1568704_a_at",0.8570893948841,0.471708769665432,0.732220986604328,-5.68186621285809,0.192830904087685,"CHERP","calcium homeostasis endoplasmic reticulum protein",TRUE
+"202229_s_at",0.94409288114477,0.750107806252158,-0.322486006998979,-5.88915682088626,-0.174484176964547,"CHERP","calcium homeostasis endoplasmic reticulum protein",TRUE
+"202230_s_at",0.978382390212526,0.896085534015226,-0.13211527110347,-5.93118563838287,-0.037605942667394,"CHERP","calcium homeostasis endoplasmic reticulum protein",TRUE
+"218803_at",0.68033297785336,0.147755306027564,-1.49990166388915,-4.89958908223666,-0.580208206386315,"CHFR","checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase",TRUE
+"223931_s_at",0.883113132668064,0.540754358822023,-0.621281304131477,-5.75341045401197,-0.220451056795383,"CHFR","checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase",TRUE
+"204697_s_at",0.897030683969189,0.583106859422935,-0.557005821980782,-5.78968887230207,-0.497544919724268,"CHGA","chromogranin A",TRUE
+"204260_at",0.705559553212919,0.177482416792434,1.39285784449972,-5.03650376557005,0.833288657357065,"CHGB","chromogranin B",TRUE
+"216546_s_at",0.539609110035715,0.0444770475683006,2.13044641084594,-3.94202900978383,1.12724387784719,"CHI3L1","chitinase 3 like 1",TRUE
+"209395_at",0.929234395612144,0.688748164015598,-0.405846412564241,-5.85977554797481,-0.653746573026532,"CHI3L1","chitinase 3 like 1",TRUE
+"209396_s_at",0.97928472590149,0.899330709832618,-0.127965411597112,-5.9317108965362,-0.187792389830143,"CHI3L1","chitinase 3 like 1",TRUE
+"213060_s_at",0.774230543658252,0.2892074726919,1.08587540334817,-5.38113553350407,0.731949931749423,"CHI3L2","chitinase 3 like 2",TRUE
+"220630_s_at",0.668518995965071,0.134792014842596,1.55215906895599,-4.8297945113717,0.95715552070018,"CHIA","chitinase, acidic",TRUE
+"1570015_at",0.9181984176728,0.652891302518468,0.455910543495374,-5.83894921409732,0.345518263792111,"CHIAP2","chitinase, acidic pseudogene 2",TRUE
+"1557786_s_at",0.902521078772712,0.601577914628114,0.529714714718951,-5.80393112691872,0.205584599586897,"CHIC1","cysteine rich hydrophobic domain 1",TRUE
+"228345_at",0.925091998149497,0.675515958141474,0.424192117075093,-5.85241985095242,0.40101714959366,"CHIC1","cysteine rich hydrophobic domain 1",TRUE
+"1559481_at",0.953902670233338,0.787100816276795,0.273370012135944,-5.90335009243478,0.280118514680349,"CHIC1","cysteine rich hydrophobic domain 1",TRUE
+"219492_at",0.974451535839172,0.875060801378283,-0.15906227510158,-5.92736789843214,-0.0573243527082532,"CHIC2","cysteine rich hydrophobic domain 2",TRUE
+"223061_at",0.776983560547865,0.295889612990161,1.070563683673,-5.39636169416518,0.545281304011306,"CHID1","chitinase domain containing 1",TRUE
+"208168_s_at",0.975196332002567,0.879363458184535,0.15353848697093,-5.9282079404833,0.0647822773652704,"CHIT1","chitinase 1",TRUE
+"204266_s_at",0.774230543658252,0.288757476864407,-1.0869156413941,-5.38009410834085,-0.486369123344264,"CHKA","choline kinase alpha",TRUE
+"204233_s_at",0.8920930097751,0.563258045100686,-0.58681786798308,-5.77333833608604,-0.302427303752511,"CHKA","choline kinase alpha",TRUE
+"204193_at",0.973684290975695,0.873311299192084,-0.161309740948856,-5.92701763397064,-0.0744202916240404,"CHKB","choline kinase beta",TRUE
+"240954_at",0.647518308302168,0.11862235508953,1.62351534147218,-4.73146481824253,0.852486228655218,"CHKB-AS1","CHKB antisense RNA 1 (head to head)",TRUE
+"238557_at",0.981557175782601,0.912357028657166,0.111330013543242,-5.93364844168555,0.0851613418575665,"CHKB-AS1","CHKB antisense RNA 1 (head to head)",TRUE
+"210070_s_at",0.90344422113846,0.604300830491795,0.525726289424489,-5.80595426383886,0.290079869460449,"CHKB-CPT1B///CPT1B","CHKB-CPT1B readthrough (NMD candidate)///carnitine palmitoyltransferase 1B",TRUE
+"210069_at",0.961899417580562,0.826985705839276,0.221169861389916,-5.91588629334443,0.129184953279047,"CHKB-CPT1B///CPT1B","CHKB-CPT1B readthrough (NMD candidate)///carnitine palmitoyltransferase 1B",TRUE
+"204591_at",0.552420073963858,0.0502737119894702,2.07032710262286,-4.04323865523109,1.72555869415999,"CHL1","cell adhesion molecule L1 like",TRUE
+"234583_at",0.898623566722697,0.588250089830855,0.549364489080692,-5.79374666781778,0.449745065814776,"CHL1","cell adhesion molecule L1 like",TRUE
+"1562121_at",0.820893155804534,0.381767543565963,0.892401897495436,-5.55906564154617,0.293302468176054,"CHL1-AS1","CHL1 antisense RNA 1",TRUE
+"227871_at",0.790817398514927,0.320611380859319,1.01596731585712,-5.44907091506968,0.350852090390998,"CHM","CHM, Rab escort protein 1",TRUE
+"207099_s_at",0.81031378318664,0.353980073805562,-0.946745776470386,-5.51229780571447,-0.577352785251485,"CHM","CHM, Rab escort protein 1",TRUE
+"1569183_a_at",0.833141091249911,0.410437225291566,-0.838987504021662,-5.60253478753566,-0.809831501502606,"CHM","CHM, Rab escort protein 1",TRUE
+"1566337_x_at",0.514490373584066,0.034716223430216,2.24987556761584,-3.7356320416904,0.669820523872516,"CHML","CHM like, Rab escort protein 2",TRUE
+"206079_at",0.732963666545614,0.217358630944897,1.26971982838678,-5.18354514818496,0.648544585067093,"CHML","CHM like, Rab escort protein 2",TRUE
+"1565949_x_at",0.738061563377262,0.224920491291039,1.24838664254406,-5.20784460880963,1.00059050377654,"CHML","CHM like, Rab escort protein 2",TRUE
+"1565951_s_at",0.850964124514683,0.453998653889396,0.762165733984139,-5.66064285620176,0.427253387337222,"CHML","CHM like, Rab escort protein 2",TRUE
+"226350_at",0.851650449893991,0.455686124766722,0.759282738521037,-5.66272120757607,0.418790213529846,"CHML","CHM like, Rab escort protein 2",TRUE
+"1565947_a_at",0.989669132517581,0.950492269435301,-0.0627956758198532,-5.93776302871482,-0.0427162228543141,"CHML","CHM like, Rab escort protein 2",TRUE
+"201933_at",0.936143408699214,0.715196039853355,-0.369591178670805,-5.87336992552864,-0.121951445452098,"CHMP1A","charged multivesicular body protein 1A",TRUE
+"218178_s_at",0.366473876333673,0.010776363552835,2.78402743029541,-2.7384879314353,1.0940882891292,"CHMP1B","charged multivesicular body protein 1B",TRUE
+"218177_at",0.563949924132502,0.0557984728944442,2.01855193971578,-4.12888708362103,0.854030947683567,"CHMP1B","charged multivesicular body protein 1B",TRUE
+"202121_s_at",0.969859842767097,0.855804401262626,0.183848590998321,-5.92323399519948,0.0959423784355309,"CHMP2A","charged multivesicular body protein 2A",TRUE
+"202538_s_at",0.64513208805899,0.116165377128136,1.63505951923595,-4.71523510326327,0.714806162839855,"CHMP2B","charged multivesicular body protein 2B",TRUE
+"202537_s_at",0.769847953580141,0.277417553343714,1.11352533960493,-5.35315262791637,0.522342877559559,"CHMP2B","charged multivesicular body protein 2B",TRUE
+"202536_at",0.944963505981344,0.752375881890807,0.31945251781944,-5.89010059768174,0.169006169298443,"CHMP2B","charged multivesicular body protein 2B",TRUE
+"218572_at",0.803135302652907,0.34095993443193,-0.973199374980918,-5.48861504247374,-0.508643961919182,"CHMP4A///TM9SF1","charged multivesicular body protein 4A///transmembrane 9 superfamily member 1",TRUE
+"218571_s_at",0.910159094731364,0.626095310108249,-0.494104661284837,-5.82146668606115,-0.230904758390215,"CHMP4A///TM9SF1","charged multivesicular body protein 4A///transmembrane 9 superfamily member 1",TRUE
+"225119_at",0.915421702513799,0.643504869656645,0.469208554317353,-5.83301845721435,0.226788385911751,"CHMP4B","charged multivesicular body protein 4B",TRUE
+"225498_at",0.961475152596758,0.825358058472275,0.223286829665687,-5.91542910374011,0.0853064729470461,"CHMP4B","charged multivesicular body protein 4B",TRUE
+"226803_at",0.758920166935337,0.25615073730418,1.16565155908235,-5.29870936514017,0.522750314459289,"CHMP4C","charged multivesicular body protein 4C",TRUE
+"219356_s_at",0.907871409554181,0.617511389171571,0.506496420797393,-5.81549954090537,0.130186863451357,"CHMP5","charged multivesicular body protein 5",TRUE
+"218085_at",0.989524702314661,0.948409360844542,0.0654415049451327,-5.93759780403336,0.0213155956590061,"CHMP5","charged multivesicular body protein 5",TRUE
+"218743_at",0.868397087637799,0.503728727812931,-0.679709243326778,-5.71712906443812,-0.196882214504333,"CHMP6","charged multivesicular body protein 6",TRUE
+"212313_at",0.662751100646147,0.130489539980901,-1.57041957880389,-4.80496052029292,-0.583462494678674,"CHMP7","charged multivesicular body protein 7",TRUE
+"212624_s_at",0.803275622655718,0.34130582514705,-0.972487791978136,-5.48925989406854,-1.16359416936543,"CHN1","chimerin 1",TRUE
+"211419_s_at",0.402463840838386,0.0147556848739042,-2.64446823727148,-3.00925924440519,-2.53394987272604,"CHN2","chimerin 2",TRUE
+"213385_at",0.70573152022539,0.178022764365915,-1.39104993329716,-5.03874473924104,-1.94845811769679,"CHN2","chimerin 2",TRUE
+"1557769_at",0.861962516141708,0.484589906555642,0.710856004418574,-5.6965147997069,0.339492060517896,"CHN2","chimerin 2",TRUE
+"207486_x_at",0.947550014380291,0.760934220052957,-0.308033199984464,-5.89357413833449,-0.114840750423567,"CHN2","chimerin 2",TRUE
+"219867_at",0.767011398042819,0.268731053331655,1.13444903106464,-5.33156269876626,0.999439664158101,"CHODL","chondrolectin",TRUE
+"218566_s_at",0.677163945383887,0.144659805799429,1.51202760404339,-4.88356355080516,0.622425391264425,"CHORDC1","cysteine and histidine rich domain containing 1",TRUE
+"239436_at",0.974650227305537,0.875910627688795,-0.15797086466354,-5.92753622486126,-0.0820280511845519,"CHORDC1","cysteine and histidine rich domain containing 1",TRUE
+"228655_at",0.680028418258485,0.147224442376327,1.50196635790244,-4.89686770220473,0.764422907227265,"CHORDC1///NAALAD2","cysteine and histidine rich domain containing 1///N-acetylated alpha-linked acidic dipeptidase 2",TRUE
+"207993_s_at",0.958325326717984,0.811415261909307,0.241465168942105,-5.9113248900147,0.094658901858649,"CHP1","calcineurin like EF-hand protein 1",TRUE
+"214665_s_at",0.975398143273847,0.882140673870885,-0.149975680002935,-5.92873404811625,-0.0553853894087784,"CHP1","calcineurin like EF-hand protein 1",TRUE
+"206149_at",0.734585436592173,0.219153997825156,1.26460392915497,-5.18940452104203,0.468351446867657,"CHP2","calcineurin like EF-hand protein 2",TRUE
+"202175_at",0.962798893634104,0.830852584635439,0.216144602689455,-5.91695421057932,0.0653548597469928,"CHPF","chondroitin polymerizing factor",TRUE
+"55093_at",0.722314275419786,0.198760499516273,-1.32473546070707,-5.11926496744413,-0.405464827717003,"CHPF2","chondroitin polymerizing factor 2",TRUE
+"221799_at",0.886023097762234,0.54862384807605,-0.609145234106416,-5.76055308954615,-0.210535091906589,"CHPF2","chondroitin polymerizing factor 2",TRUE
+"1559739_at",0.195207003215918,0.00210307737527305,-3.4808149011422,-1.31143402626259,-2.3416809202722,"CHPT1","choline phosphotransferase 1",TRUE
+"230364_at",0.296090407530139,0.00535107853825947,-3.08744128720539,-2.13018146653252,-1.65736858406064,"CHPT1","choline phosphotransferase 1",TRUE
+"221675_s_at",0.308861881799719,0.00641412468206687,-3.00975472614479,-2.28820443449584,-1.64706646035376,"CHPT1","choline phosphotransferase 1",TRUE
+"231764_at",0.643082025527735,0.113438121933154,1.64811622702666,-4.69677258041215,0.571530582051258,"CHRAC1","chromatin accessibility complex 1",TRUE
+"221674_s_at",0.55937703282623,0.0535648067922912,2.03890841303993,-4.09538290338068,1.17169952028525,"CHRD","chordin",TRUE
+"211248_s_at",0.812302873476553,0.360495424695729,-0.93375500721269,-5.52370884747326,-0.44228637288161,"CHRD","chordin",TRUE
+"209763_at",0.410562165607909,0.0159456718480102,2.60964182350525,-3.07580699481115,1.98115880202391,"CHRDL1","chordin like 1",TRUE
+"223987_at",0.785240391134777,0.310735456837531,1.03740815314654,-5.42866730261753,0.777019393860604,"CHRDL2","chordin like 2",TRUE
+"231783_at",0.751342080982751,0.244235990952107,-1.19627046426111,-5.26571255373509,-1.10493662827859,"CHRM1","cholinergic receptor muscarinic 1",TRUE
+"221330_at",0.985361089461736,0.927344196939321,0.0922299264271041,-5.93554119586691,0.0393449437617011,"CHRM2","cholinergic receptor muscarinic 2",TRUE
+"242488_at",0.538502554109027,0.0439202147957273,2.13658710917766,-3.93158749162724,1.4676352521025,"CHRM3","cholinergic receptor muscarinic 3",TRUE
+"1559634_at",0.579036829255831,0.0619548945291389,1.96597865903582,-4.21437395543342,1.57091470866087,"CHRM3","cholinergic receptor muscarinic 3",TRUE
+"214596_at",0.597654932724127,0.0750420426573904,1.86801784110284,-4.36952052512435,1.46110254077889,"CHRM3","cholinergic receptor muscarinic 3",TRUE
+"1564339_a_at",0.670002076145692,0.13569150414561,1.54840250775665,-4.83487497026519,1.17961159534378,"CHRM3","cholinergic receptor muscarinic 3",TRUE
+"1553705_a_at",0.920491425364243,0.661509955176009,-0.443773407620856,-5.84421633025629,-0.331920088461823,"CHRM3","cholinergic receptor muscarinic 3",TRUE
+"1559633_a_at",0.979347742195592,0.900357691444833,0.126652612891933,-5.93187357624274,0.159142552929449,"CHRM3","cholinergic receptor muscarinic 3",TRUE
+"1557733_a_at",0.284209497912182,0.00480829969032955,3.13305493992632,-2.03675494894359,2.15470885126791,"CHRM3-AS2","CHRM3 antisense RNA 2",TRUE
+"221357_at",0.643688366500038,0.114463662690408,1.6431758104717,-4.70377169532491,1.02858601297197,"CHRM4","cholinergic receptor muscarinic 4",TRUE
+"221347_at",0.734087872722726,0.218474217923076,1.26653716309614,-5.18719271554388,1.04965322732422,"CHRM5","cholinergic receptor muscarinic 5",TRUE
+"211039_at",0.907189812622248,0.61609079568222,0.508554911510913,-5.81449432456983,0.391698441221865,"CHRNA1","cholinergic receptor nicotinic alpha 1 subunit",TRUE
+"206633_at",0.930899509890345,0.694260761034839,0.398245486264394,-5.86272937563492,0.159905623218276,"CHRNA1","cholinergic receptor nicotinic alpha 1 subunit",TRUE
+"220210_at",0.832605695407954,0.408997604307524,0.841611449225303,-5.60045776858855,0.45812076439743,"CHRNA10","cholinergic receptor nicotinic alpha 10 subunit",TRUE
+"1568675_at",0.899331416659389,0.590088730892631,0.546640836026349,-5.79517985585889,0.323734890375461,"CHRNA10","cholinergic receptor nicotinic alpha 10 subunit",TRUE
+"239717_at",0.900750978800947,0.596318379117974,0.537443452493301,-5.79996836138487,0.245550181518999,"CHRNA10","cholinergic receptor nicotinic alpha 10 subunit",TRUE
+"207868_at",0.792716268502624,0.324328000996123,1.00801820007024,-5.4565375637662,0.280883812988762,"CHRNA2","cholinergic receptor nicotinic alpha 2 subunit",TRUE
+"211772_x_at",0.717383438122835,0.193164307705433,1.34207268060514,-5.09853150703331,0.448339525483091,"CHRNA3","cholinergic receptor nicotinic alpha 3 subunit",TRUE
+"211587_x_at",0.912244494826693,0.632224711512718,0.48530411499806,-5.82561683800216,0.248499281908312,"CHRNA3","cholinergic receptor nicotinic alpha 3 subunit",TRUE
+"210221_at",0.919437319385127,0.657728754789496,0.449089803896339,-5.84192634315673,0.288587070156227,"CHRNA3","cholinergic receptor nicotinic alpha 3 subunit",TRUE
+"216900_s_at",0.786851686785014,0.31257211089739,1.03338486176816,-5.4325252606651,0.28409472279443,"CHRNA4","cholinergic receptor nicotinic alpha 4 subunit",TRUE
+"206736_x_at",0.796574238955031,0.329396378025319,-0.997279434465355,-5.46654010307661,-0.985404845260986,"CHRNA4","cholinergic receptor nicotinic alpha 4 subunit",TRUE
+"216886_at",0.842981138657703,0.436947150792123,0.791669653080899,-5.63894635197424,0.803849596743205,"CHRNA4","cholinergic receptor nicotinic alpha 4 subunit",TRUE
+"206735_at",0.960561518765858,0.820733276829736,-0.229307697187678,-5.91410512006202,-0.101251749486777,"CHRNA4","cholinergic receptor nicotinic alpha 4 subunit",TRUE
+"206533_at",0.741179283455757,0.231416031968418,1.23049479391754,-5.22795130033832,0.90751785647951,"CHRNA5","cholinergic receptor nicotinic alpha 5 subunit",TRUE
+"207568_at",0.801086839730802,0.337343586014325,0.980668891606885,-5.4818200618551,0.346631429866475,"CHRNA6","cholinergic receptor nicotinic alpha 6 subunit",TRUE
+"221107_at",0.758438958502277,0.255522852648132,1.16723832288751,-5.29701775011763,0.755606535432081,"CHRNA9","cholinergic receptor nicotinic alpha 9 subunit",TRUE
+"206703_at",0.0602075678670986,0.000134455111541485,4.60805859320961,1.11189452995432,2.02663858567602,"CHRNB1","cholinergic receptor nicotinic beta 1 subunit",TRUE
+"206635_at",0.856631989847095,0.470738734467579,0.733843685966931,-5.68073679447408,0.440590885601333,"CHRNB2","cholinergic receptor nicotinic beta 2 subunit",TRUE
+"241389_at",0.997288583476358,0.986185658680085,-0.0175110379378558,-5.93953413054365,-0.00929888154311076,"CHRNB2","cholinergic receptor nicotinic beta 2 subunit",TRUE
+"217086_at",0.957289701021675,0.806784675507595,0.247520572329619,-5.90988683784777,0.213925276076627,"CHRNB3","cholinergic receptor nicotinic beta 3 subunit",TRUE
+"207859_s_at",0.993225426079816,0.968336408966682,-0.0401458432667019,-5.93889851707843,-0.0140510288079811,"CHRNB3","cholinergic receptor nicotinic beta 3 subunit",TRUE
+"207516_at",0.926209999527899,0.679492165336487,0.418664046547892,-5.85466998513001,0.359717149981726,"CHRNB4","cholinergic receptor nicotinic beta 4 subunit",TRUE
+"207024_at",0.998384473324293,0.993290757356362,-0.00850427862128212,-5.9396482550631,-0.0039475362435617,"CHRND","cholinergic receptor nicotinic delta subunit",TRUE
+"215916_at",0.778170595080965,0.297580145250798,1.06672926812368,-5.40014440980643,0.418896678346783,"CHRNE","cholinergic receptor nicotinic epsilon subunit",TRUE
+"207274_at",0.974982245454858,0.877892689253804,0.155426113905428,-5.92792420684491,0.0803272305256764,"CHRNE","cholinergic receptor nicotinic epsilon subunit",TRUE
+"221355_at",0.811263413918865,0.35541258895923,0.943875801389576,-5.51483122998407,0.255573087468113,"CHRNG","cholinergic receptor nicotinic gamma subunit",TRUE
+"242124_at",0.774230543658252,0.288569091440374,1.08735147145315,-5.37965751664407,0.319080654761795,"CHST1","carbohydrate sulfotransferase 1",TRUE
+"205567_at",0.848490355649813,0.448912309426285,-0.770894939250885,-5.65430459196769,-0.711760357571048,"CHST1","carbohydrate sulfotransferase 1",TRUE
+"204065_at",0.804347638345604,0.343039875020968,-0.968927835445996,-5.49247953844991,-0.570883271360468,"CHST10","carbohydrate sulfotransferase 10",TRUE
+"226368_at",0.230315024802536,0.00291921924441075,3.34383763452881,-1.59958734466417,2.41163654631458,"CHST11","carbohydrate (chondroitin 4) sulfotransferase 11",TRUE
+"226372_at",0.431769566611896,0.0192042977232006,2.52545964868064,-3.2348540422147,2.87608626062353,"CHST11","carbohydrate (chondroitin 4) sulfotransferase 11",TRUE
+"219634_at",0.527902864382624,0.0404846220458407,2.17610737184244,-3.86393792933682,3.1037286396788,"CHST11","carbohydrate (chondroitin 4) sulfotransferase 11",TRUE
+"218927_s_at",0.812302873476553,0.359047158935494,0.936628925405624,-5.52119687838386,0.386005642009946,"CHST12","carbohydrate (chondroitin 4) sulfotransferase 12",TRUE
+"222786_at",0.827768017240356,0.396648363613388,0.864366209308475,-5.58219240955192,0.348525453748911,"CHST12","carbohydrate (chondroitin 4) sulfotransferase 12",TRUE
+"239647_at",0.650490742096872,0.120611263717093,1.61431623399138,-4.74433411812062,0.775511279922938,"CHST13","carbohydrate sulfotransferase 13",TRUE
+"242503_at",0.929972194057784,0.690915804682583,0.402854729987408,-5.8609447192303,0.157718576280569,"CHST13","carbohydrate sulfotransferase 13",TRUE
+"226314_at",0.900717283106192,0.596121789550417,0.53773297547897,-5.79981882899128,0.226004452312138,"CHST14","carbohydrate sulfotransferase 14",TRUE
+"203066_at",0.790240875783718,0.319693943332839,-1.01793942099098,-5.44721028948063,-1.08173700956695,"CHST15","carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15",TRUE
+"244874_at",0.919354071504066,0.656350327376818,0.451031149603297,-5.84108346050553,0.433541118881712,"CHST15","carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15",TRUE
+"243478_at",0.834303441371375,0.412431962943866,0.83536140780227,-5.60539509961849,0.785574846786597,"CHST2","carbohydrate sulfotransferase 2",TRUE
+"203921_at",0.967701855457407,0.848081454488891,-0.193821675781322,-5.92140260376885,-0.194921661165226,"CHST2","carbohydrate sulfotransferase 2",TRUE
+"209834_at",0.547343369043481,0.0478575390390577,2.09458772091729,-4.00262021889502,2.17663126642753,"CHST3","carbohydrate sulfotransferase 3",TRUE
+"32094_at",0.555096042605915,0.0513131611349062,2.06021011386857,-4.06008627967291,2.27048670476011,"CHST3","carbohydrate sulfotransferase 3",TRUE
+"208252_s_at",0.55937703282623,0.0532234111496339,2.04208614639141,-4.09013273422849,1.63482173375286,"CHST3","carbohydrate sulfotransferase 3",TRUE
+"220446_s_at",0.686108994812404,0.154744400688747,1.47326749339129,-4.93442424364688,0.448849684511957,"CHST4","carbohydrate sulfotransferase 4",TRUE
+"223942_x_at",0.594500139507723,0.0713314588230821,-1.89416383563232,-4.3286515047701,-0.954566196977966,"CHST5","carbohydrate sulfotransferase 5",TRUE
+"221164_x_at",0.85334340854827,0.460740326229179,0.750685952589627,-5.66887438277832,0.298844183131935,"CHST5","carbohydrate sulfotransferase 5",TRUE
+"223786_at",0.885312914741353,0.546842444501344,0.611884329304131,-5.75895287800623,0.421404368930266,"CHST6","carbohydrate sulfotransferase 6",TRUE
+"206756_at",0.954449231029359,0.791028237309922,0.268197760397286,-5.90470961088608,0.323431012189002,"CHST7","carbohydrate sulfotransferase 7",TRUE
+"221065_s_at",0.575983019059817,0.0610589406213205,-1.97333352638983,-4.20250611887294,-1.93701691882427,"CHST8","carbohydrate sulfotransferase 8",TRUE
+"224400_s_at",0.747104241359439,0.2389848167041,1.2101212128109,-5.25054159627391,1.45930234603002,"CHST9","carbohydrate sulfotransferase 9",TRUE
+"223737_x_at",0.766363949125066,0.26666802253506,1.13949100102797,-5.32630712908931,1.28395122672411,"CHST9","carbohydrate sulfotransferase 9",TRUE
+"203044_at",0.908709061737317,0.6207686226386,-0.501784913009891,-5.81778532434792,-0.182542190907151,"CHSY1","chondroitin sulfate synthase 1",TRUE
+"242100_at",0.595419021493991,0.0720882825195907,1.8887360102455,-4.33716858896814,1.75453165116406,"CHSY3","chondroitin sulfate synthase 3",TRUE
+"226569_s_at",0.997608949249317,0.988104248774892,0.0150788278790599,-5.93957273730041,0.00426788591026117,"CHTF18","chromosome transmission fidelity factor 18",TRUE
+"224732_at",0.863408882018863,0.48797258289669,0.705300330548262,-5.70025631921478,0.196808542763987,"CHTF8","chromosome transmission fidelity factor 8",TRUE
+"209927_s_at",0.839519981963042,0.426279111012199,0.810489436579106,-5.62470175135961,0.284471668209338,"CHTOP","chromatin target of PRMT1",TRUE
+"202560_s_at",0.84772210282622,0.446972986786867,-0.774238985329062,-5.65185842964835,-0.240659253403523,"CHTOP","chromatin target of PRMT1",TRUE
+"202559_x_at",0.936992192746977,0.718941180278472,-0.364498933359214,-5.875178897178,-0.0807023400449722,"CHTOP","chromatin target of PRMT1",TRUE
+"209666_s_at",0.923539366135798,0.671856941711045,0.429291098417524,-5.85031865681098,0.202702308383055,"CHUK","conserved helix-loop-helix ubiquitous kinase",TRUE
+"233268_s_at",0.751464513744428,0.244561655812638,-1.19541887293508,-5.26664036207135,-0.462555198853385,"CHURC1","churchill domain containing 1",TRUE
+"223210_at",0.945644577306271,0.754699609158832,0.316347764311071,-5.89105739976595,0.162650844196353,"CHURC1","churchill domain containing 1",TRUE
+"226736_at",0.971094654049796,0.861495768269174,0.17651125339783,-5.92451981693364,0.122285980937111,"CHURC1","churchill domain containing 1",TRUE
+"225851_at",0.831013183269159,0.404911196692656,-0.849091785983468,-5.59450338446692,-0.263235003782516,"CHURC1-FNTB///FNTB","CHURC1-FNTB readthrough///farnesyltransferase, CAAX box, beta",TRUE
+"204764_at",0.907189812622248,0.616159006707401,-0.508456020471971,-5.81454270665587,-0.16406068552112,"CHURC1-FNTB///FNTB","CHURC1-FNTB readthrough///farnesyltransferase, CAAX box, beta",TRUE
+"1773_at",0.984801578023171,0.925398274789144,-0.0947077273312316,-5.93531568598571,-0.0304083298607871,"CHURC1-FNTB///FNTB","CHURC1-FNTB readthrough///farnesyltransferase, CAAX box, beta",TRUE
+"217501_at",0.877972322256644,0.529705953256148,-0.63848041499403,-5.7430556404045,-0.230264866944673,"CIAO1","cytosolic iron-sulfur assembly component 1",TRUE
+"203536_s_at",0.990810941805126,0.955883905070149,0.0559489983104129,-5.93815894670797,0.0181086514606079,"CIAO1","cytosolic iron-sulfur assembly component 1",TRUE
+"239053_at",0.993432824584085,0.968994467948226,0.0393110450077328,-5.9389308217479,0.0116261077598878,"CIAO1","cytosolic iron-sulfur assembly component 1",TRUE
+"208968_s_at",0.760905446901853,0.259978127682902,-1.15604102070342,-5.30891182731025,-0.342310881897406,"CIAPIN1","cytokine induced apoptosis inhibitor 1",TRUE
+"208424_s_at",0.767011398042819,0.268500242414211,-1.13501170906195,-5.33097720234299,-0.388679235942339,"CIAPIN1","cytokine induced apoptosis inhibitor 1",TRUE
+"230838_s_at",0.832873237326597,0.410015840071014,0.839754941377664,-5.60192793896212,0.261373532016266,"CIAPIN1","cytokine induced apoptosis inhibitor 1",TRUE
+"227285_at",0.89203601623083,0.562277372877289,0.588304580653168,-5.77250134410066,0.355219437345285,"CIART","circadian associated repressor of transcription",TRUE
+"201953_at",0.969946179106301,0.857918437240693,0.181121981744822,-5.92371791053815,0.0682976222931178,"CIB1","calcium and integrin binding 1",TRUE
+"205008_s_at",0.693742297578797,0.162856466228566,1.4435512106215,-4.97269379593458,1.68045236430982,"CIB2","calcium and integrin binding family member 2",TRUE
+"205007_s_at",0.768852835478002,0.272174297709405,1.12609675120244,-5.34022354091748,1.05928040721502,"CIB2","calcium and integrin binding family member 2",TRUE
+"214065_s_at",0.96696492045873,0.845904185671974,-0.19663690179923,-5.92086819169808,-0.133627593766415,"CIB2","calcium and integrin binding family member 2",TRUE
+"1552750_at",0.860085676417428,0.479230662117136,-0.719704199087571,-5.69049820750654,-0.454704055002302,"CIB3","calcium and integrin binding family member 3",TRUE
+"1552751_a_at",0.998347572104896,0.992164721585446,0.00993162711124736,-5.93963543831157,0.00586903143235507,"CIB3","calcium and integrin binding family member 3",TRUE
+"236378_at",0.79814964343286,0.332441917327783,0.990881582472868,-5.47245308809141,0.582643843981671,"CIB4","calcium and integrin binding family member 4",TRUE
+"212784_at",0.306787493213918,0.00615865195001957,-3.0272266059163,-2.25278978574061,-1.01328080027986,"CIC","capicua transcriptional repressor",TRUE
+"221295_at",0.579147493561207,0.0623343262701169,1.96289222775694,-4.21934526257066,1.19904829599596,"CIDEA","cell death-inducing DFFA-like effector a",TRUE
+"221188_s_at",0.689950875648652,0.159343319136548,1.45627023222309,-4.95639136212535,1.49360014178216,"CIDEB","cell death-inducing DFFA-like effector b",TRUE
+"219398_at",0.666643938027574,0.133468651610251,-1.55772368563358,-4.82225095139928,-0.432843616538745,"CIDEC","cell death inducing DFFA like effector c",TRUE
+"1554839_at",0.874480604680453,0.520852736754294,-0.652403292590707,-5.73447427981224,-0.2272889804853,"CIDECP","cell death-inducing DFFA-like effector c pseudogene",TRUE
+"211884_s_at",0.782206338814045,0.304141327081596,-1.0519928931872,-5.41456884734327,-0.725503902392064,"CIITA","class II major histocompatibility complex transactivator",TRUE
+"205101_at",0.954449231029359,0.790947711156642,-0.268303734515309,-5.90468201451222,-0.235416971587796,"CIITA","class II major histocompatibility complex transactivator",TRUE
+"210925_at",0.979388236370534,0.900692256401851,-0.126224985204516,-5.93192620545841,-0.0752456989407229,"CIITA","class II major histocompatibility complex transactivator",TRUE
+"206227_at",0.959584210327095,0.817425496978046,0.233619308120312,-5.91313546550872,0.09242937419467,"CILP","cartilage intermediate layer protein",TRUE
+"1552289_a_at",0.846015118644589,0.444028346495201,0.779333455053546,-5.64811263583059,0.465742761222693,"CILP2","cartilage intermediate layer protein 2",TRUE
+"1552288_at",0.89390639630277,0.569511544203815,-0.577368606785482,-5.77861018627612,-0.39434794467898,"CILP2","cartilage intermediate layer protein 2",TRUE
+"217598_at",0.81304218438764,0.36240862073424,-0.929970334730158,-5.52700604369902,-0.328748874003747,"CINP","cyclin dependent kinase 2 interacting protein",TRUE
+"218267_at",0.879960488971225,0.534967352214235,-0.630266099629982,-5.74803505581154,-0.157222543461272,"CINP","cyclin dependent kinase 2 interacting protein",TRUE
+"230223_at",0.952237574337645,0.781200244569788,0.281155215365372,-5.90125516184485,0.176873011110888,"CINP","cyclin dependent kinase 2 interacting protein",TRUE
+"225623_at",0.485183483700012,0.0279710782496388,-2.35189901809444,-3.55402405163073,-0.907524530128951,"CIPC","CLOCK interacting pacemaker",TRUE
+"209571_at",0.991249206045988,0.958979826042637,-0.0520188403144164,-5.93836559346439,-0.0155189921732983,"CIR1","corepressor interacting with RBPJ, 1",TRUE
+"200810_s_at",0.670152406964446,0.135831254333161,-1.54782071143239,-4.8356609351672,-0.862789945707787,"CIRBP","cold inducible RNA binding protein",TRUE
+"200811_at",0.78885145722244,0.31514628281618,-1.02777390643214,-5.43788306470296,-0.568657292958044,"CIRBP","cold inducible RNA binding protein",TRUE
+"230142_s_at",0.818306374318321,0.371414558483465,-0.91233183825132,-5.54220999562072,-0.457068010339073,"CIRBP","cold inducible RNA binding protein",TRUE
+"228519_x_at",0.873665367559788,0.519157878438098,-0.655083456744436,-5.73280196567741,-0.215088653473027,"CIRBP","cold inducible RNA binding protein",TRUE
+"225191_at",0.885694554133555,0.547498617314516,-0.610874846763181,-5.75954343537526,-0.418680478837723,"CIRBP","cold inducible RNA binding protein",TRUE
+"1552868_at",0.951399215823566,0.777651051696153,-0.285846544420543,-5.89996457897609,-0.123334907145534,"CIRBP-AS1","CIRBP antisense RNA 1",TRUE
+"239126_at",0.975398143273847,0.881208867222372,0.151170843000684,-5.92855893612841,0.0737095830030627,"CIRBP-AS1","CIRBP antisense RNA 1",TRUE
+"218597_s_at",0.756207465685724,0.251155624334576,1.17835598547406,-5.28510898253499,0.488832610193612,"CISD1","CDGSH iron sulfur domain 1",TRUE
+"244275_at",0.872668627020452,0.516744317976468,-0.658908491614367,-5.73040390819167,-0.227999518343915,"CISD2","CDGSH iron sulfur domain 2",TRUE
+"226689_at",0.885029460971826,0.545826433295866,-0.613448667488219,-5.75803586676446,-0.201130310972394,"CISD2","CDGSH iron sulfur domain 2",TRUE
+"226686_at",0.920564553801456,0.662273799856321,-0.44270101689293,-5.84467500957143,-0.122563344199957,"CISD2","CDGSH iron sulfur domain 2",TRUE
+"230727_at",0.776374093185677,0.293836472067512,-1.07524169495467,-5.3917303179617,-0.566991821261604,"CISD3","CDGSH iron sulfur domain 3",TRUE
+"226727_at",0.813418501361393,0.36330499161047,-0.928201741416381,-5.52854261556876,-0.647971449591397,"CISD3","CDGSH iron sulfur domain 3",TRUE
+"223961_s_at",0.185392143728903,0.00181492611886829,-3.54204690880459,-1.18177387865907,-3.53634111791408,"CISH","cytokine inducible SH2 containing protein",TRUE
+"223377_x_at",0.406164654174876,0.0153848559450602,-2.6257389724287,-3.0451009368697,-1.59224645006248,"CISH","cytokine inducible SH2 containing protein",TRUE
+"221223_x_at",0.45894822559666,0.022915933349408,-2.44449387521313,-3.38527371922762,-1.69287511817076,"CISH","cytokine inducible SH2 containing protein",TRUE
+"207144_s_at",0.767965891104819,0.271009869676875,-1.12891259768459,-5.3373099839289,-1.47737256994927,"CITED1","Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1",TRUE
+"207980_s_at",0.859122424227944,0.475992639556369,-0.725078201750008,-5.68680944309574,-0.425259265383561,"CITED2","Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2",TRUE
+"227287_at",0.861962516141708,0.484391041621185,0.71118331537963,-5.69629349694913,0.319435054413302,"CITED2","Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2",TRUE
+"209357_at",0.89967769475675,0.590944800476473,-0.545374132274698,-5.79584403850121,-0.271424876041561,"CITED2","Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2",TRUE
+"228625_at",0.954577684533304,0.792530483584035,0.266221346308923,-5.9052222984762,0.275778586409166,"CITED4","Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4",TRUE
+"211358_s_at",0.853768202875953,0.462474866162031,-0.747748656619351,-5.670961555483,-0.334651155356186,"CIZ1","CDKN1A interacting zinc finger protein 1",TRUE
+"205516_x_at",0.914873260596855,0.641356693286088,-0.472263958726274,-5.8316321971363,-0.187013924474707,"CIZ1","CDKN1A interacting zinc finger protein 1",TRUE
+"213977_s_at",0.927538966917087,0.682318580329662,-0.414742578961421,-5.85624857499388,-0.169267105050963,"CIZ1","CDKN1A interacting zinc finger protein 1",TRUE
+"213976_at",0.967777603239069,0.848399901934421,-0.193410055555844,-5.92148009790112,-0.0720465356376794,"CIZ1","CDKN1A interacting zinc finger protein 1",TRUE
+"218252_at",0.691063803085828,0.160743857158242,1.45117283919803,-4.96293885014024,0.452779916447408,"CKAP2","cytoskeleton associated protein 2",TRUE
+"1554264_at",0.75536453281804,0.249424416955063,1.18280301057974,-5.28031790102995,0.555152490218296,"CKAP2","cytoskeleton associated protein 2",TRUE
+"230128_at",0.831957210365167,0.408157895697423,0.843144668871532,-5.59924132501907,0.562959929296816,"CKAP2","cytoskeleton associated protein 2",TRUE
+"216412_x_at",0.844790348750798,0.44180511194097,-0.783193504631442,-5.64525904650415,-0.490326696572175,"CKAP2///IGLC1","cytoskeleton associated protein 2///immunoglobulin lambda constant 1",TRUE
+"234884_x_at",0.755940660414394,0.250631581288058,1.17969969623938,-5.28366297333023,0.628432370096802,"CKAP2///IGLV@///IGLC1","cytoskeleton associated protein 2///immunoglobulin lambda variable cluster///immunoglobulin lambda constant 1",TRUE
+"229610_at",0.672164152353115,0.137970867512398,1.53897431472704,-4.84758298449369,0.571509356991507,"CKAP2L","cytoskeleton associated protein 2 like",TRUE
+"200998_s_at",0.788658093314838,0.314871833908909,1.02837058846459,-5.43731455392027,0.622554812178286,"CKAP4","cytoskeleton associated protein 4",TRUE
+"226526_s_at",0.83030603167465,0.40264132247705,-0.853267728313448,-5.59115794306087,-0.648451780700764,"CKAP4","cytoskeleton associated protein 4",TRUE
+"200999_s_at",0.937836182672692,0.724689598554948,0.356701849606367,-5.87790071398552,0.25795563476027,"CKAP4","cytoskeleton associated protein 4",TRUE
+"212832_s_at",0.921603564091029,0.665629550972246,0.43799597133398,-5.84667456349849,0.147385473683762,"CKAP5","cytoskeleton associated protein 5",TRUE
+"1555278_a_at",0.944503488452294,0.750765827309313,0.321605605164023,-5.88943164042374,0.116307439705398,"CKAP5","cytoskeleton associated protein 5",TRUE
+"200884_at",0.86481525165637,0.492558859147238,0.697803207529474,-5.7052609599247,0.626423406377082,"CKB","creatine kinase B",TRUE
+"223451_s_at",0.820504334454054,0.379630510264,0.89648634919508,-5.5556392799019,0.367645175689981,"CKLF","chemokine like factor",TRUE
+"221058_s_at",0.959513220802138,0.816994576702748,0.234181333987889,-5.91300774563212,0.0775019343858805,"CKLF","chemokine like factor",TRUE
+"219161_s_at",0.895690630367785,0.576179429964757,-0.567351305810529,-5.78410843641598,-0.19524288972759,"CKLF-CMTM1///CKLF","CKLF-CMTM1 readthrough///chemokine like factor",TRUE
+"204810_s_at",0.851733415458562,0.456441190276401,0.757994811022948,-5.66364726728298,0.336601501829509,"CKM","creatine kinase, M-type",TRUE
+"202712_s_at",0.847797601020174,0.447374326540081,-0.77354621811369,-5.6523660080212,-0.719277705334244,"CKMT1A///CKMT1B","creatine kinase, mitochondrial 1A///creatine kinase, mitochondrial 1B",TRUE
+"205295_at",0.959649219607517,0.817855246442008,0.233058885889763,-5.91326251698369,0.136526133895041,"CKMT2","creatine kinase, mitochondrial 2",TRUE
+"242585_at",0.841375110002692,0.431836640821135,0.800649298938735,-5.63218893374048,0.372231658468412,"CKMT2-AS1","CKMT2 antisense RNA 1",TRUE
+"235443_at",0.993615552413264,0.969943894483086,-0.0381066749642076,-5.93897623203063,-0.014667495939463,"CKMT2-AS1","CKMT2 antisense RNA 1",TRUE
+"201897_s_at",0.92346045063848,0.671497523557521,0.429792583936348,-5.85011067183333,0.128022429929871,"CKS1B","CDC28 protein kinase regulatory subunit 1B",TRUE
+"204170_s_at",0.807051198331174,0.348226375935913,0.958352829057263,-5.50198000824557,0.370972406099979,"CKS2","CDC28 protein kinase regulatory subunit 2",TRUE
+"212752_at",0.871744769522775,0.514230690716085,-0.662902647109263,-5.7278855357878,-0.186878504863223,"CLASP1","cytoplasmic linker associated protein 1",TRUE
+"240757_at",0.978928101156583,0.897263294501501,0.13060890610053,-5.93137823755716,0.0605697066566471,"CLASP1","cytoplasmic linker associated protein 1",TRUE
+"212308_at",0.61760967235709,0.0881320827759851,1.78396841010121,-4.49814516587044,0.624919312328984,"CLASP2","cytoplasmic linker associated protein 2",TRUE
+"212309_at",0.736094223891156,0.221367607197701,1.25834032713464,-5.19655081546289,0.410290629241141,"CLASP2","cytoplasmic linker associated protein 2",TRUE
+"212306_at",0.756952614607938,0.252529394453027,1.17484336532446,-5.28888222017755,0.36923219236594,"CLASP2","cytoplasmic linker associated protein 2",TRUE
+"238048_at",0.83242103542195,0.408685775634455,0.84218058156628,-5.60000646501432,0.561215872546681,"CLASP2","cytoplasmic linker associated protein 2",TRUE
+"1555469_a_at",0.899808883319249,0.593536670853056,0.541544494333147,-5.79784296094969,0.162451695912733,"CLASP2","cytoplasmic linker associated protein 2",TRUE
+"1558759_s_at",0.981158705865426,0.911045833683507,-0.113002953406361,-5.93346575984374,-0.0830592298708916,"CLASP2","cytoplasmic linker associated protein 2",TRUE
+"204978_at",0.647518308302168,0.118492374328936,-1.62412101343122,-4.73061551921705,-0.39454838995878,"CLASRP","CLK4 associating serine/arginine rich protein",TRUE
+"206207_at",0.729083413548563,0.210982226818137,1.28815645444582,-5.16226183338615,0.794507476952395,"CLC","Charcot-Leyden crystal galectin",TRUE
+"210107_at",0.657015752622694,0.12580477634558,1.59087935954249,-4.776865248063,0.95208466571199,"CLCA1","chloride channel accessory 1",TRUE
+"206164_at",0.8017109011727,0.33917691578424,-0.976875349753424,-5.48527694574437,-2.02038426344171,"CLCA2","chloride channel accessory 2",TRUE
+"206165_s_at",0.874474734833648,0.520721668164611,-0.652610386299222,-5.73434529624468,-1.16280351791491,"CLCA2","chloride channel accessory 2",TRUE
+"217528_at",0.929088650061781,0.687984247927545,-0.40690163329968,-5.85936112888719,-0.814708678811391,"CLCA2","chloride channel accessory 2",TRUE
+"206166_s_at",0.945946905559213,0.755529134318524,-0.315240197680181,-5.89139648262736,-0.499677938837121,"CLCA2","chloride channel accessory 2",TRUE
+"220810_at",0.528328646587879,0.0409919390014582,2.17008508267304,-3.87429659350475,2.03110173590626,"CLCA3P","chloride channel accessory 3, pseudogene",TRUE
+"220026_at",0.428626487378986,0.0186659289702673,2.53839782368569,-3.21058120276084,2.02070939709382,"CLCA4","chloride channel accessory 4",TRUE
+"207855_s_at",0.854163696308241,0.463773792318756,-0.745553335390332,-5.67251643634359,-0.394918965057508,"CLCC1","chloride channel CLIC like 1",TRUE
+"213628_at",0.954627246077849,0.793213070288355,0.265323666807915,-5.9054539153759,0.101171016861349,"CLCC1","chloride channel CLIC like 1",TRUE
+"1555543_a_at",0.981557175782601,0.912349453952525,-0.111339677089847,-5.93364739425917,-0.0492479951145288,"CLCC1","chloride channel CLIC like 1",TRUE
+"219500_at",0.646692716816097,0.117615023111485,1.62822383793998,-4.72485593520482,1.02384783241564,"CLCF1","cardiotrophin-like cytokine factor 1",TRUE
+"208437_at",0.812302873476553,0.357102758265319,0.940499641502336,-5.51780244802704,0.556692817966897,"CLCN1","chloride voltage-gated channel 1",TRUE
+"213499_at",0.96882227301574,0.852864442140325,-0.187642824048135,-5.92254860752876,-0.0511128689397724,"CLCN2","chloride voltage-gated channel 2",TRUE
+"201734_at",0.80818658267298,0.349991749617651,-0.954777773458044,-5.50517023140081,-0.435179180807655,"CLCN3","chloride voltage-gated channel 3",TRUE
+"201732_s_at",0.87045636854107,0.509077036795674,-0.671125923385635,-5.72265472942092,-0.285604387918754,"CLCN3","chloride voltage-gated channel 3",TRUE
+"201735_s_at",0.900692252557887,0.595929625686206,-0.538016025557407,-5.79967256400787,-0.226233172966793,"CLCN3","chloride voltage-gated channel 3",TRUE
+"201733_at",0.926524168456213,0.680518656732778,-0.417239087387753,-5.85524529327441,-0.222843549571165,"CLCN3","chloride voltage-gated channel 3",TRUE
+"205148_s_at",0.606138724709726,0.0798101687564692,1.83602758930651,-4.41897697118127,2.11209888321801,"CLCN4","chloride voltage-gated channel 4",TRUE
+"214769_at",0.69313249943666,0.162396475862526,1.44520389048176,-4.97058207948277,2.15130190997334,"CLCN4","chloride voltage-gated channel 4",TRUE
+"217556_at",0.731054546207485,0.214155038872876,1.27892975226508,-5.17294587080363,1.00735889347901,"CLCN4","chloride voltage-gated channel 4",TRUE
+"231066_s_at",0.782876787164404,0.305291295017021,1.04943341201903,-5.41705579178956,0.556388252740267,"CLCN4","chloride voltage-gated channel 4",TRUE
+"205149_s_at",0.838350471423215,0.423381104564174,0.815652350478455,-5.62073905648645,0.68386865568144,"CLCN4","chloride voltage-gated channel 4",TRUE
+"226274_at",0.627942883677571,0.0993797855045637,-1.71995671822225,-4.593199276364,-0.530832243399436,"CLCN5","chloride voltage-gated channel 5",TRUE
+"232128_s_at",0.803135302652907,0.340967213790507,0.973184394446809,-5.4886286225851,0.460790606383128,"CLCN5","chloride voltage-gated channel 5",TRUE
+"206704_at",0.932091525948902,0.700203644159062,-0.390077912488013,-5.86584210174384,-0.143909803780611,"CLCN5","chloride voltage-gated channel 5",TRUE
+"232127_at",0.945432830098469,0.753382783997098,0.318106795063845,-5.89051644971485,0.111361518372722,"CLCN5","chloride voltage-gated channel 5",TRUE
+"226273_at",0.956398858120188,0.802067227326939,-0.253699308943069,-5.90838300315868,-0.0735645188183334,"CLCN5","chloride voltage-gated channel 5",TRUE
+"203950_s_at",0.946391057046703,0.757649652478715,0.312410745357139,-5.89225737428473,0.140907546756779,"CLCN6","chloride voltage-gated channel 6",TRUE
+"38069_at",0.719412173140763,0.195386289426988,-1.33514239151438,-5.10684657222661,-0.422191974649968,"CLCN7","chloride voltage-gated channel 7",TRUE
+"209235_at",0.89203601623083,0.562248520218458,0.588348341937673,-5.77247667626647,0.313693424457831,"CLCN7","chloride voltage-gated channel 7",TRUE
+"221961_at",0.952697366942815,0.78355535485898,-0.278045786228625,-5.90209888522131,-0.11719057467803,"CLCN7","chloride voltage-gated channel 7",TRUE
+"1554748_at",0.315093142651413,0.00678307505991245,2.98566703413975,-2.33690562825637,1.54805350840717,"CLCNKB","chloride voltage-gated channel Kb",TRUE
+"1554749_s_at",0.895213601869362,0.572823153277163,0.572386115012433,-5.78135660711529,0.282167688435619,"CLCNKB","chloride voltage-gated channel Kb",TRUE
+"205985_x_at",0.972819824894874,0.868370966415345,-0.167660883665697,-5.9260013197066,-0.0781939535266156,"CLCNKB","chloride voltage-gated channel Kb",TRUE
+"207047_s_at",0.728385463227073,0.209484227891067,1.29255000771127,-5.15715136933461,0.621792493191946,"CLCNKB///CLCNKA","chloride voltage-gated channel Kb///chloride voltage-gated channel Ka",TRUE
+"222549_at",0.380084968057051,0.0118457208151663,2.74226303676129,-2.82018025571289,3.25484247280479,"CLDN1","claudin 1",TRUE
+"218182_s_at",0.402463840838386,0.0147129349994914,2.64576793051044,-3.0067675224105,3.50405294438322,"CLDN1","claudin 1",TRUE
+"205328_at",0.149914319961378,0.00106386385267517,3.76266521841514,-0.711165436970645,1.52875426325484,"CLDN10","claudin 10",TRUE
+"1570291_at",0.755049574909504,0.248856579046598,1.1842666583925,-5.27873756891224,0.667190737003873,"CLDN10-AS1","CLDN10 antisense RNA 1",TRUE
+"228335_at",0.150704524202907,0.00108758575094674,3.75359163559785,-0.730609603382677,5.10110173131912,"CLDN11","claudin 11",TRUE
+"206908_s_at",0.606900628956089,0.0801550455327502,1.83377877403674,-4.42243067853642,0.900189702730682,"CLDN11","claudin 11",TRUE
+"1561105_at",0.94473927882008,0.751402510814266,0.320753998768259,-5.88969676364476,0.258317264254143,"CLDN11","claudin 11",TRUE
+"223249_at",0.471793372004737,0.0257471189272764,2.39055314031227,-3.48401760011915,0.795786054630621,"CLDN12","claudin 12",TRUE
+"210689_at",0.791211889207316,0.321454863161945,1.01415765848641,-5.45077540360518,0.334853596591508,"CLDN14","claudin 14",TRUE
+"219640_at",0.661126451085706,0.128863732770377,-1.57744981774844,-4.7953387213064,-0.655951277625118,"CLDN15","claudin 15",TRUE
+"1552845_at",0.973493137611142,0.872395853013866,0.162486090382323,-5.9268323471663,0.0928406251261205,"CLDN15","claudin 15",TRUE
+"220332_at",0.85334340854827,0.461260545242517,-0.749804313801632,-5.66950166832599,-0.548893155596271,"CLDN16","claudin 16",TRUE
+"221328_at",0.784552021081681,0.30794538896479,-1.04355217511619,-5.42274971745022,-0.594273298758263,"CLDN17","claudin 17",TRUE
+"232578_at",0.68747436517451,0.156272994558929,1.46757304305204,-4.94180670433501,1.00969136028556,"CLDN18","claudin 18",TRUE
+"214135_at",0.807944276806637,0.349732367611937,0.955302279484649,-5.50470286819877,0.594003883183198,"CLDN18","claudin 18",TRUE
+"221133_s_at",0.90466378569832,0.609014839356662,0.518841693368173,-5.8094114516591,0.262299268051044,"CLDN18","claudin 18",TRUE
+"221132_at",0.978197434639598,0.894228805805936,-0.134490678602622,-5.93087744638302,-0.0483296319278885,"CLDN18","claudin 18",TRUE
+"1552535_at",0.671498069723584,0.137650302223923,-1.54029248321223,-4.84580995464007,-0.61447663317695,"CLDN19","claudin 19",TRUE
+"1554804_a_at",0.791211889207316,0.32160550741992,1.01383480627402,-5.45107920409473,0.319424628031094,"CLDN19","claudin 19",TRUE
+"1554805_at",0.996203643989992,0.981062441828936,-0.024006347331444,-5.93940278787025,-0.00791315588357655,"CLDN19","claudin 19",TRUE
+"223509_at",0.826974115143008,0.395262380720025,0.866948290230715,-5.58009110506915,0.537729921979728,"CLDN2","claudin 2",TRUE
+"1554812_at",0.981492876419106,0.912020952656107,0.111758778161623,-5.9336018807639,0.0425086850747931,"CLDN20","claudin 20",TRUE
+"228704_s_at",0.659382629906731,0.127328009730501,1.58415847740781,-4.78612568474181,0.758009014346333,"CLDN23","claudin 23",TRUE
+"228707_at",0.815977292327875,0.366930276414989,0.921078431560951,-5.53470416235091,0.681921393953173,"CLDN23","claudin 23",TRUE
+"228706_s_at",0.982476966653206,0.915386471863559,0.107466014911679,-5.93405998080109,0.092831500469825,"CLDN23","claudin 23",TRUE
+"203954_x_at",0.86343247188677,0.488086098008311,-0.705114280745172,-5.70038113209549,-1.14274859030556,"CLDN3","claudin 3",TRUE
+"203953_s_at",0.922652183389116,0.66937213546068,-0.432760371624098,-5.84887493599876,-0.792660258056099,"CLDN3","claudin 3",TRUE
+"1569421_at",0.971216837324271,0.861907810219761,0.175980436672544,-5.92461081432505,0.0764366313959637,"CLDN4","claudin 4",TRUE
+"201428_at",0.971216837324271,0.862928355926224,0.174665931995292,-5.92483498237627,0.225875667905855,"CLDN4","claudin 4",TRUE
+"204482_at",0.768852835478002,0.272713103244917,1.12479678160447,-5.34156644959224,0.520072572387788,"CLDN5","claudin 5",TRUE
+"208474_at",0.530381742213219,0.0415243169078004,2.16383740617672,-3.88502408630741,1.25751380938635,"CLDN6","claudin 6",TRUE
+"237810_at",0.673622120503302,0.139987994982219,1.5307372237019,-4.85863517973188,1.49222080800791,"CLDN6","claudin 6",TRUE
+"202790_at",0.731965025847759,0.215620963598814,1.27470233568583,-5.17781912748452,1.68680736528674,"CLDN7","claudin 7",TRUE
+"214598_at",0.920389295526597,0.661209853046066,-0.444194877097588,-5.84403576269808,-0.643680857609896,"CLDN8","claudin 8",TRUE
+"214635_at",0.934926171367715,0.710956061901259,0.375368299514444,-5.87128767256676,0.118723833701091,"CLDN9","claudin 9",TRUE
+"1554149_at",0.502098735582167,0.0323445232832031,2.28349714491556,-3.6763037589295,0.841831784315053,"CLDND1","claudin domain containing 1",TRUE
+"208925_at",0.587626678796111,0.0668287643119199,1.92754129815817,-4.27590346490175,0.847036233664856,"CLDND1","claudin domain containing 1",TRUE
+"1567287_at",0.90344422113846,0.604382528910859,0.525606754247818,-5.80601466853973,0.404342801823972,"CLDND1","claudin domain containing 1",TRUE
+"239146_at",0.936992192746977,0.71825932520537,0.36542531285619,-5.87485165320312,0.25691563801073,"CLDND1","claudin domain containing 1",TRUE
+"231162_at",0.811432370461795,0.355587507864874,0.943525894761003,-5.51513962196888,0.659234398701552,"CLDND2","claudin domain containing 2",TRUE
+"206682_at",0.881970070870254,0.539299121717785,-0.623535804974101,-5.75206862256104,-0.456079456932845,"CLEC10A","C-type lectin domain family 10 member A",TRUE
+"211709_s_at",0.557589172116298,0.0525143944358413,-2.04874426905409,-4.07911492821016,-2.21865425100462,"CLEC11A","C-type lectin domain family 11 member A",TRUE
+"205131_x_at",0.739367922105944,0.227306379890318,-1.24176958601255,-5.21530990601022,-1.10540138735822,"CLEC11A","C-type lectin domain family 11 member A",TRUE
+"210783_x_at",0.867259912702635,0.49944096403824,-0.686627719965816,-5.71262630109993,-0.52953493142379,"CLEC11A","C-type lectin domain family 11 member A",TRUE
+"1552398_a_at",0.755868740464627,0.250431891443024,1.18021227707934,-5.28311098982464,0.893587433182902,"CLEC12A","C-type lectin domain family 12 member A",TRUE
+"243106_at",0.923708852928185,0.672403513892504,0.428528696790516,-5.85063439654992,0.158713538861853,"CLEC12A","C-type lectin domain family 12 member A",TRUE
+"1569401_at",0.947778780715578,0.762134310767036,-0.306435300801341,-5.8940501990008,-0.243741353093827,"CLEC12A","C-type lectin domain family 12 member A",TRUE
+"231357_at",0.899808883319249,0.593321660493091,-0.541861872336433,-5.79767782224395,-0.407180015375805,"CLEC12B","C-type lectin domain family 12 member B",TRUE
+"231600_at",0.96569241146864,0.839574122229771,0.204831056107614,-5.91926901227869,0.106870853558485,"CLEC12B","C-type lectin domain family 12 member B",TRUE
+"226244_at",0.934081042629428,0.708424347298346,0.378824052049128,-5.8700268840323,0.153317802586332,"CLEC14A","C-type lectin domain family 14 member A",TRUE
+"212786_at",0.8017109011727,0.339177349723167,-0.976874453510575,-5.48527776100729,-0.249888993313132,"CLEC16A","C-type lectin domain family 16 member A",TRUE
+"231221_at",0.856631989847095,0.47066608464797,0.733965295764734,-5.68065205698426,0.425522061384452,"CLEC16A","C-type lectin domain family 16 member A",TRUE
+"230022_at",0.978928101156583,0.897200679111997,0.130688983859281,-5.9313680545536,0.0815094078040284,"CLEC18A///CLEC18C","C-type lectin domain family 18 member A///C-type lectin domain family 18 member C",TRUE
+"219761_at",0.789795896476304,0.318342059144737,1.02085262866397,-5.44445579121207,0.587616024946718,"CLEC1A","C-type lectin domain family 1 member A",TRUE
+"220496_at",0.792203833738687,0.322952560588964,1.0109525569156,-5.45378748959174,0.54238956650943,"CLEC1B","C-type lectin domain family 1 member B",TRUE
+"1556209_at",0.724067243569133,0.201387017066626,1.31672974511161,-5.12876230493208,0.815271383964529,"CLEC2B","C-type lectin domain family 2 member B",TRUE
+"209732_at",0.774230543658252,0.286292339754634,1.09263503138377,-5.37435231849732,1.11399743275357,"CLEC2B","C-type lectin domain family 2 member B",TRUE
+"228426_at",0.702630084418366,0.174272822584316,1.40368788901508,-5.0230291784874,1.22602283256665,"CLEC2D","C-type lectin domain family 2 member D",TRUE
+"233500_x_at",0.831195244996286,0.405343554043639,0.84829806630442,-5.59513752027168,0.735206279814444,"CLEC2D","C-type lectin domain family 2 member D",TRUE
+"220132_s_at",0.895690630367785,0.575342507615785,0.568605396725669,-5.7834252031539,0.254093043877808,"CLEC2D","C-type lectin domain family 2 member D",TRUE
+"235522_at",0.908948198134019,0.621666338605072,-0.500488414333988,-5.81841066165664,-0.506324868704636,"CLEC2D","C-type lectin domain family 2 member D",TRUE
+"232173_at",0.535243600695458,0.0428077211285974,2.1490688541566,-3.91030547512354,1.92794230974659,"CLEC2L","C-type lectin domain family 2 member L",TRUE
+"231802_at",0.872505590628774,0.515715833056243,-0.660541449104282,-5.7293760682649,-0.706444877403626,"CLEC3A","C-type lectin domain family 3 member A",TRUE
+"221724_s_at",0.812302873476553,0.357470956163177,-0.939765584267256,-5.51844716813911,-0.388313372821643,"CLEC4A","C-type lectin domain family 4 member A",TRUE
+"219947_at",0.82064687791745,0.381340346643765,-0.893217184670127,-5.55838287083665,-0.630761295731804,"CLEC4A","C-type lectin domain family 4 member A",TRUE
+"1552552_s_at",0.941952420964607,0.739267068838117,-0.337028495362754,-5.88450978245653,-0.176353188111536,"CLEC4C","C-type lectin domain family 4 member C",TRUE
+"1555687_a_at",0.946050828306305,0.755746813083418,-0.314949623714296,-5.89148524714904,-0.317158632000254,"CLEC4C","C-type lectin domain family 4 member C",TRUE
+"1552772_at",0.732505233366135,0.21684745499656,-1.27118236061702,-5.18186635585762,-0.779766694381565,"CLEC4D","C-type lectin domain family 4 member D",TRUE
+"1552773_at",0.757361197594703,0.253300266839968,1.1728785375572,-5.2909885323441,0.330582292800818,"CLEC4D","C-type lectin domain family 4 member D",TRUE
+"222934_s_at",0.791437231688251,0.321959705664565,1.01307612424686,-5.45179277119287,0.582815801555147,"CLEC4E","C-type lectin domain family 4 member E",TRUE
+"219859_at",0.949761528403753,0.772594307037683,0.29254192015657,-5.8980859888448,0.124858988102031,"CLEC4E","C-type lectin domain family 4 member E",TRUE
+"1552410_at",0.499428826990278,0.0314903247310926,2.29616088447773,-3.65382317566022,0.656453107237475,"CLEC4F","C-type lectin domain family 4 member F",TRUE
+"1559065_a_at",0.668518995965071,0.134732092312727,1.55241005965548,-4.8294547194903,0.891075925753439,"CLEC4G","C-type lectin domain family 4 member G",TRUE
+"1559194_a_at",0.500281297945596,0.0317632379378662,2.29208102380833,-3.66107366210586,0.566670098057298,"CLEC4GP1","C-type lectin domain family 4 member G pseudogene 1",TRUE
+"210481_s_at",0.639134221230867,0.109836399500416,1.66577058660931,-4.67163050236417,0.802370873302404,"CLEC4M","C-type lectin domain family 4 member M",TRUE
+"207995_s_at",0.969642324744141,0.855172902424686,0.184663351778801,-5.92308799388065,0.121203962707312,"CLEC4M","C-type lectin domain family 4 member M",TRUE
+"219890_at",0.828068961116677,0.397806297808699,-0.862213441305017,-5.58393988096508,-0.558836563651444,"CLEC5A","C-type lectin domain family 5 member A",TRUE
+"1554406_a_at",0.758268628978425,0.255258217812104,1.16790796452306,-5.29630325471047,0.828940936034756,"CLEC7A","C-type lectin domain family 7 member A",TRUE
+"1555213_a_at",0.801587742916188,0.338800143879892,0.977653818681249,-5.48456855781354,0.426008806921116,"CLEC7A","C-type lectin domain family 7 member A",TRUE
+"1555756_a_at",0.874834820370747,0.521552556411876,0.651298034139035,-5.73516200029669,1.08366456169246,"CLEC7A","C-type lectin domain family 7 member A",TRUE
+"241098_at",0.899808883319249,0.593618577201708,0.541423606710475,-5.79790583668532,0.629256214772232,"CLEC7A","C-type lectin domain family 7 member A",TRUE
+"1555214_a_at",0.921312278448293,0.664603140596259,0.439434013962977,-5.84606564814297,0.425670693738372,"CLEC7A","C-type lectin domain family 7 member A",TRUE
+"221698_s_at",0.944503488452294,0.750758965525724,0.321614784575016,-5.88942877888594,0.303523814842121,"CLEC7A","C-type lectin domain family 7 member A",TRUE
+"244413_at",0.935999751372286,0.714089575447502,0.371097532681234,-5.87283006033181,0.264295591002505,"CLECL1","C-type lectin like 1",TRUE
+"1561899_at",0.976371465776674,0.886290292522701,0.144655944790119,-5.92949665446319,0.10205932601119,"CLECL1","C-type lectin like 1",TRUE
+"205830_at",0.852396762065801,0.45818177302884,-0.755030737867173,-5.66577287692801,-0.808256145920069,"CLGN","calmegin",TRUE
+"228316_at",0.748924337581408,0.242104301729477,1.201865842693,-5.25960210496562,0.732346851229756,"CLHC1","clathrin heavy chain linker domain containing 1",TRUE
+"208659_at",0.784918343662568,0.309616406485652,1.03986772144876,-5.4263021572556,0.324068622755254,"CLIC1","chloride intracellular channel 1",TRUE
+"217382_at",0.991399575197268,0.960084585414631,-0.0506165953948702,-5.9384356827007,-0.0301375156066559,"CLIC1P1","chloride intracellular channel 1 pseudogene 1",TRUE
+"213415_at",0.962437545364198,0.82888448351366,0.218701557542903,-5.91641388519672,0.222926119150401,"CLIC2","chloride intracellular channel 2",TRUE
+"219529_at",0.890816525789205,0.559620353029547,-0.592339406130083,-5.77021949093881,-0.834168883040002,"CLIC3","chloride intracellular channel 3",TRUE
+"201559_s_at",0.688234475234403,0.157669607273242,1.46240959748102,-4.94848073658325,0.895015742556531,"CLIC4","chloride intracellular channel 4",TRUE
+"221881_s_at",0.772704859424721,0.283242166448248,1.09976120480138,-5.36716070705326,0.747034886804917,"CLIC4","chloride intracellular channel 4",TRUE
+"201560_at",0.800179799309599,0.335756321712163,0.983964727229844,-5.47880680855972,0.766003877547323,"CLIC4","chloride intracellular channel 4",TRUE
+"217628_at",0.442846733327149,0.020632265575198,2.49271485279939,-3.29599833258558,2.27388172915137,"CLIC5","chloride intracellular channel 5",TRUE
+"243917_at",0.62282585384278,0.0933706090036526,1.75333396070364,-4.54395550118515,0.61951575851667,"CLIC5","chloride intracellular channel 5",TRUE
+"213317_at",0.642021982677251,0.112334690576482,1.65347403642448,-4.68916398006068,2.36602086429716,"CLIC5","chloride intracellular channel 5",TRUE
+"219866_at",0.718706241731185,0.194770377388769,1.33705718391932,-5.10455278904647,0.900990350417979,"CLIC5","chloride intracellular channel 5",TRUE
+"234329_at",0.941345931827527,0.737594377555776,0.33927888982186,-5.88377255721132,0.213718199829701,"CLIC5","chloride intracellular channel 5",TRUE
+"227742_at",0.687949239097856,0.157310268844462,-1.46373456406888,-4.94676996404521,-2.50267571106826,"CLIC6","chloride intracellular channel 6",TRUE
+"242913_at",0.94895689004559,0.769501015426405,-0.296644309431042,-5.89691362795085,-0.181323804311653,"CLIC6","chloride intracellular channel 6",TRUE
+"201768_s_at",0.712948021516228,0.187085363416828,-1.36135826388292,-5.0752027306582,-0.390148712530641,"CLINT1","clathrin interactor 1",TRUE
+"201769_at",0.721907781985393,0.198094355775333,-1.32677901190653,-5.11683288979288,-0.36902764093009,"CLINT1","clathrin interactor 1",TRUE
+"230609_at",0.831942523499222,0.407899098810126,0.843617609521704,-5.59886568078901,0.385619626768558,"CLINT1","clathrin interactor 1",TRUE
+"242287_at",0.547343369043481,0.0478818892676183,2.0943377931708,-4.00304021690012,0.758583273443107,"CLIP1","CAP-Gly domain containing linker protein 1",TRUE
+"1558924_s_at",0.819018525257656,0.373133747314925,0.908997149518093,-5.54505424391585,0.580611846186154,"CLIP1","CAP-Gly domain containing linker protein 1",TRUE
+"210716_s_at",0.966593471043185,0.84446995395742,0.198492262145212,-5.92051179289815,0.0684980314874828,"CLIP1","CAP-Gly domain containing linker protein 1",TRUE
+"1568012_at",0.975265330414469,0.880139107490472,0.152543226888143,-5.9283561476454,0.072268370652778,"CLIP1","CAP-Gly domain containing linker protein 1",TRUE
+"201975_at",0.993213867476782,0.967530923922532,-0.0411677026465594,-5.9388580497358,-0.0136814793818694,"CLIP1","CAP-Gly domain containing linker protein 1",TRUE
+"240444_x_at",0.993225426079816,0.968372196142236,0.040100443745093,-5.9389002913814,0.0293029401328715,"CLIP1","CAP-Gly domain containing linker protein 1",TRUE
+"236747_at",0.913697616562839,0.638172097029839,-0.476801908256336,-5.82955704515439,-0.333720245647881,"CLIP1-AS1","CLIP1 antisense RNA 1",TRUE
+"211031_s_at",0.399312926596283,0.0141670474979956,2.66268428146493,-2.9742830257956,2.98051493062755,"CLIP2","CAP-Gly domain containing linker protein 2",TRUE
+"235243_at",0.839466826665106,0.425492901422291,0.811887928562429,-5.62363069684581,0.568421893667356,"CLIP3","CAP-Gly domain containing linker protein 3",TRUE
+"212358_at",0.876953995372682,0.526046761646655,-0.644219443856341,-5.7395399339388,-0.344227972685671,"CLIP3","CAP-Gly domain containing linker protein 3",TRUE
+"219944_at",0.171054203824867,0.00146228228024972,3.63151218045864,-0.991523005592036,3.25292865229901,"CLIP4","CAP-Gly domain containing linker protein family member 4",TRUE
+"226425_at",0.40221114169538,0.0144899238778177,2.65260615811419,-2.99364791516032,3.87457774993113,"CLIP4","CAP-Gly domain containing linker protein family member 4",TRUE
+"214683_s_at",0.961395512423249,0.825013269022393,-0.223735407073113,-5.91533167049876,-0.101068405321005,"CLK1","CDC like kinase 1",TRUE
+"203229_s_at",0.610033432202476,0.0825854837243592,-1.81816457854238,-4.44632700566529,-0.544146274739763,"CLK2","CDC like kinase 2",TRUE
+"202140_s_at",0.794426378358553,0.326238859723426,-1.00395592162652,-5.46033276666029,-0.329143815965928,"CLK3","CDC like kinase 3",TRUE
+"238072_at",0.998347572104896,0.992737625584607,0.00920541890386226,-5.93964220723171,0.00643035156557481,"CLK3","CDC like kinase 3",TRUE
+"241403_at",0.879948283821082,0.534841795982047,0.630461613381417,-5.74791725848153,0.420283877776146,"CLK4","CDC like kinase 4",TRUE
+"1568836_at",0.965914344760007,0.840362433513866,0.203809830471664,-5.91947186259042,0.137448711309831,"CLK4","CDC like kinase 4",TRUE
+"210346_s_at",0.969829083058377,0.85554571426451,-0.184182333932874,-5.92317426783605,-0.0648195738155639,"CLK4","CDC like kinase 4",TRUE
+"228751_at",0.999134201687551,0.99724069742281,0.00349750836987167,-5.93967752271956,0.00166840891598419,"CLK4","CDC like kinase 4",TRUE
+"225757_s_at",0.623503825356688,0.094643243447393,-1.74611499188629,-4.55466557781453,-1.73939555909282,"CLMN","calmin",TRUE
+"225759_x_at",0.789795896476304,0.318555454977333,-1.02039220224546,-5.4448916073808,-0.615980247759454,"CLMN","calmin",TRUE
+"213839_at",0.92219130725941,0.668059502477013,-0.434595241414372,-5.84810675001191,-0.439539494444084,"CLMN","calmin",TRUE
+"221042_s_at",0.959203345279235,0.81521465527195,-0.236503608186688,-5.91247677437155,-0.252388829548762,"CLMN","calmin",TRUE
+"228082_at",0.20483217497972,0.00231524982418778,3.440773038584,-1.3959540962924,3.46526171995513,"CLMP","CXADR like membrane protein",TRUE
+"226834_at",0.280199223932988,0.00463080525727284,3.1490559836731,-2.0038743666195,4.18781442438049,"CLMP","CXADR like membrane protein",TRUE
+"210859_x_at",0.661974206478491,0.129806481396372,-1.5733643269082,-4.80093434859585,-0.908837012012016,"CLN3","CLN3, battenin",TRUE
+"209275_s_at",0.703902004301726,0.175391729415089,-1.39989447746089,-5.02775869317011,-0.809226565023268,"CLN3","CLN3, battenin",TRUE
+"204085_s_at",0.804779510162821,0.343862422823192,0.967243465664878,-5.49399913500248,0.395687491492183,"CLN5","ceroid-lipofuscinosis, neuronal 5",TRUE
+"204084_s_at",0.818268955967428,0.371337710753796,0.91248113743337,-5.54208242947614,0.467369427408823,"CLN5","ceroid-lipofuscinosis, neuronal 5",TRUE
+"214252_s_at",0.989475734766121,0.948041748531853,0.0659085161932985,-5.93756793284749,0.024080432294264,"CLN5","ceroid-lipofuscinosis, neuronal 5",TRUE
+"1567078_x_at",0.587947964200177,0.0669190705298162,1.92685272144676,-4.27699810517216,1.33037555381054,"CLN6","ceroid-lipofuscinosis, neuronal 6, late infantile, variant",TRUE
+"1567079_at",0.676468346171966,0.143352009842673,1.51721449997744,-4.87667710684362,0.637214902834188,"CLN6","ceroid-lipofuscinosis, neuronal 6, late infantile, variant",TRUE
+"218161_s_at",0.822178297049143,0.386742546659694,-0.882950989550432,-5.56693824441506,-0.33260908726932,"CLN6","ceroid-lipofuscinosis, neuronal 6, late infantile, variant",TRUE
+"1567080_s_at",0.864079461576774,0.491105006255847,-0.700175442103617,-5.70368291064262,-0.254317198692954,"CLN6","ceroid-lipofuscinosis, neuronal 6, late infantile, variant",TRUE
+"1567076_at",0.922168942129244,0.667909602792136,0.434804875727701,-5.84801878143141,0.241846835364873,"CLN6","ceroid-lipofuscinosis, neuronal 6, late infantile, variant",TRUE
+"222539_at",0.955892698633978,0.799920067747219,-0.256514909209511,-5.90768549649591,-0.102927256281542,"CLN6","ceroid-lipofuscinosis, neuronal 6, late infantile, variant",TRUE
+"1567081_x_at",0.982417021128743,0.915107754349625,0.10782144301764,-5.93402273191739,0.031187459109363,"CLN6","ceroid-lipofuscinosis, neuronal 6, late infantile, variant",TRUE
+"229958_at",0.854400503339099,0.465900918944428,-0.741966156984107,-5.67504780340816,-0.53900578065654,"CLN8","ceroid-lipofuscinosis, neuronal 8",TRUE
+"219340_s_at",0.861659105448003,0.483306631393863,-0.712969513554541,-5.69508409663687,-0.387721947729466,"CLN8","ceroid-lipofuscinosis, neuronal 8",TRUE
+"219341_at",0.867972140419125,0.501592806659193,0.683151452952552,-5.71489421394756,0.499895012077022,"CLN8","ceroid-lipofuscinosis, neuronal 8",TRUE
+"223912_s_at",0.976371465776674,0.886929739221167,0.143836569706343,-5.92961167283156,0.0998151330741983,"CLN8","ceroid-lipofuscinosis, neuronal 8",TRUE
+"222874_s_at",0.981949416086005,0.913702360189766,0.109613857376413,-5.93383301487108,0.0888730131917139,"CLN8","ceroid-lipofuscinosis, neuronal 8",TRUE
+"241483_at",0.411110107932987,0.016169000842581,-2.6033792161964,-3.08772829310066,-1.90265433006951,"CLNK","cytokine dependent hematopoietic cell linker",TRUE
+"1570239_a_at",0.89205696974366,0.562510370372871,0.587951232132585,-5.77270045840456,0.40592471424115,"CLNK","cytokine dependent hematopoietic cell linker",TRUE
+"1562587_at",0.973295310311232,0.871043673138342,0.164224073137137,-5.92655613991265,0.137363283359098,"CLNK","cytokine dependent hematopoietic cell linker",TRUE
+"242492_at",0.726432421917557,0.20535417490915,1.30479057322517,-5.14283559908759,0.886074958977933,"CLNS1A","chloride nucleotide-sensitive channel 1A",TRUE
+"209143_s_at",0.896328858604647,0.58039450553007,0.561049097678184,-5.78751975532414,0.243924793086256,"CLNS1A","chloride nucleotide-sensitive channel 1A",TRUE
+"217563_at",0.802679132489125,0.34041752166964,0.974316248219978,-5.48760204067955,0.51226149625172,"CLOCK","clock circadian regulator",TRUE
+"227531_at",0.887931586103322,0.553367734154268,-0.601873786115365,-5.76476754211048,-0.188828576217031,"CLOCK","clock circadian regulator",TRUE
+"204980_at",0.888705384925779,0.555117810809057,-0.599199523321727,-5.76630522495257,-0.22046939686955,"CLOCK","clock circadian regulator",TRUE
+"225856_at",0.948962238903406,0.769598065888597,-0.296515520410793,-5.89695067878845,-0.119483594836877,"CLOCK","clock circadian regulator",TRUE
+"229496_at",0.646860439310262,0.117967654199785,1.62657172889045,-4.72717652830946,1.02841839340306,"CLP1","cleavage and polyadenylation factor I subunit 1",TRUE
+"204370_at",0.763391321581193,0.263134391340085,1.14819413297634,-5.31718699712282,0.336504211694594,"CLP1","cleavage and polyadenylation factor I subunit 1",TRUE
+"224510_s_at",0.514490373584066,0.0347063350425987,2.25001133569962,-3.73539351924457,0.984307253002892,"CLPB","ClpB homolog, mitochondrial AAA ATPase chaperonin",TRUE
+"221845_s_at",0.956734254923335,0.803894150244673,0.251305289605731,-5.90897005358303,0.228095200202983,"CLPB","ClpB homolog, mitochondrial AAA ATPase chaperonin",TRUE
+"202799_at",0.668587404382295,0.134891406634496,-1.55174296095671,-4.83035774396333,-0.451615170907122,"CLPP","caseinolytic mitochondrial matrix peptidase proteolytic subunit",TRUE
+"206131_at",0.980001024522674,0.904919180413082,-0.120824346223448,-5.93257557907474,-0.050834262819178,"CLPS","colipase",TRUE
+"211136_s_at",0.724623760403195,0.202015703959021,-1.31482557398499,-5.13101410748893,-0.533526493305194,"CLPTM1","CLPTM1, transmembrane protein",TRUE
+"201640_x_at",0.766550448794594,0.267772901613996,-1.13678716882697,-5.32912806295315,-0.379459751752892,"CLPTM1","CLPTM1, transmembrane protein",TRUE
+"223020_at",0.838730875025347,0.424189961704635,0.814209124152252,-5.62184915353629,0.31427393973877,"CLPTM1L","CLPTM1 like",TRUE
+"226935_s_at",0.884227283169589,0.543188023839455,0.617518218630975,-5.7556397310311,0.271128553247612,"CLPTM1L","CLPTM1 like",TRUE
+"229416_at",0.899798994481376,0.591600728685873,0.544404182854439,-5.79635160896919,0.149249431516049,"CLPTM1L","CLPTM1 like",TRUE
+"223507_at",0.44838973820172,0.0212980000020095,-2.47816475025644,-3.32303359148575,-0.786244361550995,"CLPX","caseinolytic mitochondrial matrix peptidase chaperone subunit",TRUE
+"204809_at",0.714590421965913,0.189927930326887,-1.35227969884555,-5.08621928405217,-0.45979629722483,"CLPX","caseinolytic mitochondrial matrix peptidase chaperone subunit",TRUE
+"1555695_a_at",0.39259320496653,0.0133628889701456,2.68875815980648,-2.92402248960551,1.5452156609924,"CLRN1","clarin 1",TRUE
+"1555034_at",0.954054753819891,0.789212771604899,0.270587716337287,-5.90408461925015,0.160100083321619,"CLRN1","clarin 1",TRUE
+"1555035_a_at",0.95877806139143,0.813332551795464,0.238960647401699,-5.91190931658078,0.126350126107481,"CLRN1","clarin 1",TRUE
+"1560432_at",0.897024165042344,0.582900836991979,0.557312607330656,-5.78952482330666,0.350715171567379,"CLRN1-AS1","CLRN1 antisense RNA 1",TRUE
+"229777_at",0.960344430556183,0.820125148122966,0.23010004238456,-5.91392827426652,0.203988105935426,"CLRN3","clarin 3",TRUE
+"242150_at",0.575270671804438,0.0609097744686949,1.97456728848745,-4.20051237446517,0.646281038738134,"CLSPN","claspin",TRUE
+"243840_at",0.663789119801086,0.131718701062885,1.56515254967445,-4.81214703498179,0.608949046090783,"CLSPN","claspin",TRUE
+"1553120_at",0.887929552412429,0.553324488329365,0.60193992532963,-5.76472942872253,0.267644790763801,"CLSPN","claspin",TRUE
+"219621_at",0.966925852992772,0.845756593778761,-0.196827797896281,-5.92083167608667,-0.137739154178496,"CLSPN","claspin",TRUE
+"201561_s_at",0.677013732819214,0.144120376381279,1.51416238038443,-4.88073156971867,0.426232927852396,"CLSTN1","calsyntenin 1",TRUE
+"219414_at",0.51470556386048,0.0352417018870664,-2.24271097749,-3.7482068411269,-3.0321382301102,"CLSTN2","calsyntenin 2",TRUE
+"229580_at",0.55074985379986,0.0489326203170607,-2.08366039529156,-4.0209531857338,-3.66125285022869,"CLSTN2","calsyntenin 2",TRUE
+"234443_at",0.380731642340006,0.0119120008716886,2.73979353108328,-2.82499348022297,1.06348060542724,"CLSTN2-AS1","CLSTN2 antisense RNA 1",TRUE
+"204375_at",0.666473481658155,0.133258127141965,1.55861312167904,-4.82104323340945,0.623835849883935,"CLSTN3","calsyntenin 3",TRUE
+"216296_at",0.766390367856479,0.266880103995413,-1.1389713629367,-5.32684973104147,-0.419196867382552,"CLTA","clathrin light chain A",TRUE
+"216293_at",0.901781358899845,0.59873907277786,-0.533882225772024,-5.80180125099427,-0.313531744593808,"CLTA","clathrin light chain A",TRUE
+"200960_x_at",0.90998880119877,0.625197563340717,0.495396950309159,-5.82085113513604,0.14401091075932,"CLTA","clathrin light chain A",TRUE
+"216295_s_at",0.913233126230689,0.636089570668595,0.479774939537844,-5.8281869866621,0.148173683247245,"CLTA","clathrin light chain A",TRUE
+"204050_s_at",0.979588787486838,0.902614014324234,0.123769134600246,-5.9322250119399,0.0372291401757892,"CLTA","clathrin light chain A",TRUE
+"1560434_x_at",0.998870448604467,0.995850480796348,-0.00525966861211253,-5.93967000658817,-0.00262012434178693,"CLTA","clathrin light chain A",TRUE
+"221996_s_at",0.796174477255647,0.328408358358734,-0.999363786684445,-5.4646062519396,-0.547024745607425,"CLTB","clathrin light chain B",TRUE
+"211043_s_at",0.931838763487749,0.698979313350042,0.391758339843449,-5.86520686990329,0.159567564225707,"CLTB","clathrin light chain B",TRUE
+"205172_x_at",0.939452234779565,0.728884526604879,0.351026117708289,-5.87984544296206,0.128482608210613,"CLTB","clathrin light chain B",TRUE
+"206284_x_at",0.951023815565189,0.776451591138974,0.287433470241194,-5.89952322017866,0.116744811175547,"CLTB","clathrin light chain B",TRUE
+"200614_at",0.804779510162821,0.343896958380725,-0.967172805770991,-5.49406282983551,-0.28222142716295,"CLTC","clathrin heavy chain",TRUE
+"210498_at",0.822173415758858,0.386628595188536,-0.883166569132806,-5.56675953252718,-0.497180437255433,"CLTC","clathrin heavy chain",TRUE
+"239871_at",0.877732414214248,0.52832730037859,0.640640133298646,-5.74173615362358,0.548654444528839,"CLTC","clathrin heavy chain",TRUE
+"220855_at",0.777826511138126,0.296945004528575,1.06816804509114,-5.39872645599997,1.03745594508512,"CLTC-IT1","CLTC intronic transcript 1 (non-protein coding)",TRUE
+"205944_s_at",0.677013732819214,0.144038538809398,-1.51448682176213,-4.88030088847613,-1.06398664139159,"CLTCL1","clathrin heavy chain like 1",TRUE
+"208792_s_at",0.332429060350567,0.00814187912408888,-2.90663730477708,-2.49564288388687,-2.18096416214371,"CLU","clusterin",TRUE
+"208791_at",0.345235484905341,0.00875530791979774,-2.87502194311591,-2.55867432747567,-2.42963199130109,"CLU","clusterin",TRUE
+"222043_at",0.522403182336918,0.0381769871453884,-2.20439467857496,-3.81504566237572,-1.52887242075427,"CLU","clusterin",TRUE
+"1559228_at",0.79782885150643,0.331511046620658,0.992832774547873,-5.47065343377712,0.960611022364207,"CLU","clusterin",TRUE
+"235080_at",0.308861881799719,0.0064400342542141,-3.00802026751857,-2.29171602399995,-1.59917633244319,"CLUAP1","clusterin associated protein 1",TRUE
+"204576_s_at",0.812302873476553,0.359299247857371,-0.936128124944165,-5.52163511685815,-0.38180010082417,"CLUAP1","clusterin associated protein 1",TRUE
+"204577_s_at",0.925511384407886,0.678269996336425,-0.420361792885271,-5.85398202524345,-0.137897968091031,"CLUAP1","clusterin associated protein 1",TRUE
+"243258_at",0.677013732819214,0.143730610585935,1.51570894422376,-4.87867791490375,0.538762545013481,"CLUH","clustered mitochondria homolog",TRUE
+"212456_at",0.877339406737153,0.527227418291077,0.642365346464284,-5.74067905247653,0.180041633291072,"CLUH","clustered mitochondria homolog",TRUE
+"238527_at",0.635916735157933,0.106972249491393,-1.68016197459421,-4.65098469562764,-0.624067178009255,"CLUHP3","clustered mitochondria homolog pseudogene 3",TRUE
+"219442_at",0.819479221404744,0.376688496385471,0.902134142120451,-5.55087762669484,0.608808818146896,"CLUHP3","clustered mitochondria homolog pseudogene 3",TRUE
+"238910_at",0.955695473298202,0.797103337418282,-0.260211746779715,-5.90675806656041,-0.253423202258063,"CLUHP3","clustered mitochondria homolog pseudogene 3",TRUE
+"235920_at",0.983567332578112,0.919806129958678,-0.101831811053849,-5.93463403536718,-0.0320386084264959,"CLUHP3///ZNF720","clustered mitochondria homolog pseudogene 3///zinc finger protein 720",TRUE
+"206556_at",0.983051865094694,0.917632687166298,-0.104602093996255,-5.93435563653351,-0.0756523175724038,"CLUL1","clusterin like 1",TRUE
+"230217_at",0.724970327905974,0.202769726535701,1.31254786400573,-5.13370402710695,0.833008997488288,"CLVS1","clavesin 1",TRUE
+"1562443_at",0.867159108376357,0.499111975093208,0.687159944410088,-5.7122781075374,0.410894344829583,"CLVS2","clavesin 2",TRUE
+"239683_at",0.6708432030569,0.136661340646311,-1.54437510763285,-4.84031091056046,-0.763736733800888,"CLYBL","citrate lyase beta like",TRUE
+"240462_at",0.897949253801113,0.586413627130064,0.552089116290638,-5.79230604541792,0.409316704145759,"CLYBL","citrate lyase beta like",TRUE
+"238440_at",0.933783656095576,0.706584314951736,-0.381338617412511,-5.86910231368616,-0.395554080336398,"CLYBL","citrate lyase beta like",TRUE
+"1566176_at",0.575270671804438,0.0608262553980602,-1.97525924791344,-4.199393807209,-1.12724048309752,"CLYBL-AS1","CLYBL antisense RNA 1",TRUE
+"1563245_at",0.98453870130544,0.924755098409527,-0.0955268358715567,-5.93523982354961,-0.0861288509886062,"CLYBL-AS2","CLYBL antisense RNA 2",TRUE
+"214533_at",0.969642324744141,0.855069615839887,-0.184796624449007,-5.92306405080483,-0.130389155150713,"CMA1","chymase 1",TRUE
+"1554862_at",0.599731655615302,0.0760789481142177,1.86091345197059,-4.38055619165591,1.08766194020788,"CMAHP","cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene",TRUE
+"229604_at",0.823074246722209,0.389726456069479,0.877320535799076,-5.57159146411357,0.731509912027571,"CMAHP","cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene",TRUE
+"205518_s_at",0.878281464330375,0.531208503409342,0.636130081430959,-5.7444867163962,0.498115117050516,"CMAHP","cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene",TRUE
+"210571_s_at",0.913123070637484,0.635147239853842,0.481121659801786,-5.8275636381539,0.554369575322308,"CMAHP","cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene",TRUE
+"241065_x_at",0.69227042558579,0.161624784753038,1.44798496447917,-4.9670241103662,0.92564877989638,"CMAS","cytidine monophosphate N-acetylneuraminic acid synthetase",TRUE
+"218111_s_at",0.759927290750921,0.257770672780367,1.16157101500133,-5.30305028372803,0.534539478627197,"CMAS","cytidine monophosphate N-acetylneuraminic acid synthetase",TRUE
+"227522_at",0.891653456393983,0.561515059772027,-0.589461182787244,-5.77184878180518,-0.438209916877252,"CMBL","carboxymethylenebutenolidase homolog",TRUE
+"234981_x_at",0.962555471240652,0.829291696663669,-0.218172384867767,-5.91652622690489,-0.0872236152142527,"CMBL","carboxymethylenebutenolidase homolog",TRUE
+"230995_at",0.990810941805126,0.954424728923286,-0.057801678145491,-5.93805631728379,-0.0374969925926738,"CMBL","carboxymethylenebutenolidase homolog",TRUE
+"228283_at",0.971242929121865,0.863474943845322,0.173962034025328,-5.92495433213703,0.0557521641522669,"CMC1","C-X9-C motif containing 1",TRUE
+"218447_at",0.657015752622694,0.126047541238004,-1.58980370122174,-4.77834941076209,-0.594473063418643,"CMC2","C-X9-C motif containing 2",TRUE
+"216862_s_at",0.968066640321622,0.849680651528691,-0.19175492296563,-5.92179004607697,-0.0780295199647085,"CMC4","C-X9-C motif containing 4",TRUE
+"210212_x_at",0.97928472590149,0.89975058695026,-0.127428651661755,-5.93177761329257,-0.0548417816269051,"CMC4","C-X9-C motif containing 4",TRUE
+"205106_at",0.969882914559333,0.856794736717688,-0.18257111486219,-5.9234616174664,-0.0838292009472417,"CMC4///MTCP1","C-X9-C motif containing 4///mature T-cell proliferation 1",TRUE
+"231643_s_at",0.522016286799917,0.0380235817081743,2.20632969498006,-3.81168700409473,0.957735469857621,"CMIP","c-Maf inducing protein",TRUE
+"224992_s_at",0.616441687539849,0.0874121042707603,1.78830049720883,-4.49162020453428,0.744375029716833,"CMIP","c-Maf inducing protein",TRUE
+"224991_at",0.65284137151906,0.121736370324899,1.60916844421926,-4.75151104679846,0.666797459024878,"CMIP","c-Maf inducing protein",TRUE
+"210659_at",0.657015752622694,0.125781011739861,1.59098475011325,-4.77671979106062,0.772112861296216,"CMKLR1","chemerin chemokine-like receptor 1",TRUE
+"229121_at",0.892502176012097,0.56474127189104,0.584571807722692,-5.77459894128323,0.398462013737907,"CMKLR1","chemerin chemokine-like receptor 1",TRUE
+"207652_s_at",0.930457281281851,0.692392957407104,-0.400818171401797,-5.86173574923094,-0.258541565950306,"CMKLR1","chemerin chemokine-like receptor 1",TRUE
+"1570533_at",0.877948371309952,0.529652382158723,0.638564279281816,-5.74300448318426,0.331271721209499,"CMPK1","cytidine/uridine monophosphate kinase 1",TRUE
+"222448_s_at",0.937236261824892,0.721573355377358,0.360925855312526,-5.87643340635996,0.103209957204916,"CMPK1","cytidine/uridine monophosphate kinase 1",TRUE
+"217870_s_at",0.986342822130003,0.935451604960945,0.0819127032257373,-5.93641596600734,0.025734063429848,"CMPK1","cytidine/uridine monophosphate kinase 1",TRUE
+"226702_at",0.632949074657601,0.103665786953119,1.69718734959171,-4.6263868750932,2.08108459122033,"CMPK2","cytidine/uridine monophosphate kinase 2",TRUE
+"224523_s_at",0.678126513742682,0.145363228017689,1.50925360061989,-4.88723875593712,0.534929426539463,"CMSS1","cms1 ribosomal small subunit homolog (yeast)",TRUE
+"1555738_at",0.81125719016705,0.35533584252621,0.944029361102595,-5.51469585623625,0.402307504334263,"CMTM1","CKLF like MARVEL transmembrane domain containing 1",TRUE
+"231219_at",0.861388867330702,0.481952388486758,-0.715203438666347,-5.69356748458524,-0.498712678560617,"CMTM1","CKLF like MARVEL transmembrane domain containing 1",TRUE
+"229967_at",0.93789466363241,0.725489832989184,0.355618217212499,-5.87827438914575,0.127936055065773,"CMTM2","CKLF like MARVEL transmembrane domain containing 2",TRUE
+"224733_at",0.521655713381635,0.0379313518036044,2.20749647528889,-3.80966092394138,2.23823798612117,"CMTM3","CKLF like MARVEL transmembrane domain containing 3",TRUE
+"1555705_a_at",0.528412182286162,0.0410922644028429,2.16890212992993,-3.87632924284612,2.17129867574812,"CMTM3","CKLF like MARVEL transmembrane domain containing 3",TRUE
+"1555704_at",0.845537307175605,0.442772357416456,0.781512687315664,-5.64650324502555,0.211141222218606,"CMTM3","CKLF like MARVEL transmembrane domain containing 3",TRUE
+"224998_at",0.744573608322482,0.235687224257753,-1.21893674533153,-5.24080694928245,-0.627969898719032,"CMTM4","CKLF like MARVEL transmembrane domain containing 4",TRUE
+"1554677_s_at",0.882880628075062,0.540498955334769,-0.621676748606696,-5.75317543237982,-0.235275496413347,"CMTM4","CKLF like MARVEL transmembrane domain containing 4",TRUE
+"225009_at",0.885312914741353,0.546431317902199,-0.612517149579316,-5.75858219226498,-0.341662415811331,"CMTM4","CKLF like MARVEL transmembrane domain containing 4",TRUE
+"230942_at",0.906878681039516,0.615247144765512,0.509778445712889,-5.81389495571406,0.190498771851581,"CMTM5","CKLF like MARVEL transmembrane domain containing 5",TRUE
+"223047_at",0.500677386446044,0.0319565350126956,2.28921074614335,-3.66617002914125,0.937125881125663,"CMTM6","CKLF like MARVEL transmembrane domain containing 6",TRUE
+"217947_at",0.555096042605915,0.0513315247289715,2.0600330344597,-4.06038068739292,0.864997829577893,"CMTM6","CKLF like MARVEL transmembrane domain containing 6",TRUE
+"1565657_at",0.868397087637799,0.503802399841027,-0.679590662104122,-5.71720586081134,-0.700181477195523,"CMTM6","CKLF like MARVEL transmembrane domain containing 6",TRUE
+"227953_at",0.904832003218088,0.609696058622231,0.517848907873491,-5.80990632885699,0.368974785197187,"CMTM6","CKLF like MARVEL transmembrane domain containing 6",TRUE
+"1560754_at",0.280199223932988,0.004679774619957,3.14458300509541,-2.01307137638037,1.08752139464412,"CMTM7","CKLF like MARVEL transmembrane domain containing 7",TRUE
+"226017_at",0.383328885347805,0.0121995742714117,2.72922740464446,-2.84556549612316,2.61124571912629,"CMTM7","CKLF like MARVEL transmembrane domain containing 7",TRUE
+"235099_at",0.882400203770826,0.539962754779342,-0.622507279876896,-5.75268135978868,-0.389391883446752,"CMTM8","CKLF like MARVEL transmembrane domain containing 8",TRUE
+"212380_at",0.974982245454858,0.877988501638469,0.155303128017887,-5.92794279848249,0.0555898707305857,"CMTR1","cap methyltransferase 1",TRUE
+"222811_at",0.864894115958506,0.493259300153435,-0.696661738894718,-5.7060184628331,-0.292992816444729,"CMTR2","cap methyltransferase 2",TRUE
+"237981_at",0.822010986888098,0.385567237438854,0.885176497571723,-5.56509138881661,0.694165159165275,"CMYA5","cardiomyopathy associated 5",TRUE
+"233520_s_at",0.848923243270856,0.44942474895225,0.770012785826538,-5.65494821899261,0.329608903052659,"CMYA5","cardiomyopathy associated 5",TRUE
+"1552587_at",0.869784729509912,0.507475471846217,-0.673690884455613,-5.72101053023881,-0.487810530124405,"CNBD1","cyclic nucleotide binding domain containing 1",TRUE
+"1552588_a_at",0.994145854504594,0.973248654363051,-0.0339149474411317,-5.93912326474143,-0.0220553525731266,"CNBD1","cyclic nucleotide binding domain containing 1",TRUE
+"1552686_at",0.661974206478491,0.129259809000689,-1.57573037218989,-4.79769511784959,-1.14808649331813,"CNBD2","cyclic nucleotide binding domain containing 2",TRUE
+"1569466_at",0.784758605763568,0.308822426366876,1.04161662441712,-5.42461732732558,0.770885047395177,"CNBD2","cyclic nucleotide binding domain containing 2",TRUE
+"1552687_a_at",0.88191340888295,0.538905038678893,-0.624146891346939,-5.7517041104025,-0.456731214161755,"CNBD2","cyclic nucleotide binding domain containing 2",TRUE
+"206158_s_at",0.949719717072385,0.772403962671381,-0.292794210237068,-5.89801435784054,-0.075120103359346,"CNBP","CCHC-type zinc finger nucleic acid binding protein",TRUE
+"227731_at",0.972899347107693,0.868700374212258,0.167237190174131,-5.92607033782466,0.0440162766229673,"CNBP","CCHC-type zinc finger nucleic acid binding protein",TRUE
+"223699_at",0.837839105061376,0.422558999946364,-0.817120982566532,-5.61960752571242,-0.519147729833367,"CNDP1","carnosine dipeptidase 1",TRUE
+"217752_s_at",0.552430474281948,0.0502971906899961,-2.07009652562093,-4.04362322862809,-0.897191548174799,"CNDP2","CNDP dipeptidase 2 (metallopeptidase M20 family)",TRUE
+"1562460_at",0.94895689004559,0.769319136185573,-0.296885682709304,-5.8968441451963,-0.190814072422964,"CNDP2","CNDP dipeptidase 2 (metallopeptidase M20 family)",TRUE
+"230950_at",0.955730092376044,0.797634298061425,0.259514601863744,-5.90693396886081,0.248551623129747,"CNDP2","CNDP dipeptidase 2 (metallopeptidase M20 family)",TRUE
+"235812_at",0.854184492233394,0.464411888749642,-0.744476226619986,-5.67327773624591,-0.243970247428434,"CNEP1R1","CTD nuclear envelope phosphatase 1 regulatory subunit 1",TRUE
+"224329_s_at",0.670152406964446,0.135918048984777,-1.5474596237765,-4.83614862117173,-1.67909211885782,"CNFN","cornifelin",TRUE
+"206417_at",0.849517610674975,0.450683270511903,0.767848852106163,-5.6565240969775,0.327151337869299,"CNGA1","cyclic nucleotide gated channel alpha 1",TRUE
+"207261_at",0.854400503339099,0.465537353758256,0.742578581275055,-5.6746164527629,0.302207326691633,"CNGA3","cyclic nucleotide gated channel alpha 3",TRUE
+"1562273_at",0.937462538530338,0.722678197668183,-0.359427501829668,-5.87695584709178,-0.271612690843351,"CNGA4","cyclic nucleotide gated channel alpha 4",TRUE
+"211099_s_at",0.82064687791745,0.381444094909311,-0.893019130459619,-5.55854878646263,-0.622335958258045,"CNGB1","cyclic nucleotide gated channel beta 1",TRUE
+"207342_at",0.843753336849204,0.439344554117979,0.787479485986116,-5.64207501815869,0.598862811476432,"CNGB1","cyclic nucleotide gated channel beta 1",TRUE
+"210769_at",0.961212424803935,0.823215193226316,0.226075499942176,-5.91482023529995,0.131648491640287,"CNGB1","cyclic nucleotide gated channel beta 1",TRUE
+"220304_s_at",0.393117358114064,0.013387919905046,-2.6879244999618,-2.92563300864348,-1.06743565005588,"CNGB3","cyclic nucleotide gated channel beta 3",TRUE
+"222959_at",0.698391916012681,0.16949325975834,1.42011442040636,-5.00242748832833,1.21476131869756,"CNGB3","cyclic nucleotide gated channel beta 3",TRUE
+"201653_at",0.822850703882235,0.388339153024007,-0.879934787381176,-5.56943438225733,-0.229939763922721,"CNIH1","cornichon family AMPA receptor auxiliary protein 1",TRUE
+"225553_at",0.948429371744093,0.765398782422341,-0.302092818962239,-5.89533155482557,-0.0979469711832781,"CNIH1","cornichon family AMPA receptor auxiliary protein 1",TRUE
+"230070_at",0.959203345279235,0.815362316876044,-0.236310902795329,-5.91252103335279,-0.220995101351127,"CNIH2","cornichon family AMPA receptor auxiliary protein 2",TRUE
+"214841_at",0.83872852514497,0.424056524200313,-0.814447095227913,-5.6216662385,-0.84153968297918,"CNIH3","cornichon family AMPA receptor auxiliary protein 3",TRUE
+"238503_at",0.948567563026335,0.766071318024524,-0.301198934181358,-5.8955930677689,-0.17007601242031,"CNIH3","cornichon family AMPA receptor auxiliary protein 3",TRUE
+"222721_at",0.640201999868781,0.110886382053175,1.66057413862256,-4.6790521217218,1.45399911446259,"CNIH4","cornichon family AMPA receptor auxiliary protein 4",TRUE
+"243051_at",0.748184017928985,0.240684870522536,-1.20561221893093,-5.25549701977602,-0.365082997965547,"CNIH4","cornichon family AMPA receptor auxiliary protein 4",TRUE
+"228306_at",0.854400503339099,0.465698329828881,-0.742307382619984,-5.67480750855461,-0.296332025979781,"CNIH4","cornichon family AMPA receptor auxiliary protein 4",TRUE
+"228437_at",0.879571582519001,0.534097421849672,-0.631621247195521,-5.74721785469806,-0.195948837849635,"CNIH4","cornichon family AMPA receptor auxiliary protein 4",TRUE
+"223993_s_at",0.957430653957785,0.807866090491609,-0.246105570954056,-5.9102260463742,-0.0628798994415973,"CNIH4","cornichon family AMPA receptor auxiliary protein 4",TRUE
+"218728_s_at",0.991246844276006,0.958867020519684,0.0521620276603773,-5.93835832870775,0.015429119731591,"CNIH4","cornichon family AMPA receptor auxiliary protein 4",TRUE
+"204740_at",0.740681080735184,0.23091214614018,1.23186897271031,-5.22641587837665,0.624359139125314,"CNKSR1","connector enhancer of kinase suppressor of Ras 1",TRUE
+"229116_at",0.7994347047598,0.334831362270801,0.985890281654148,-5.47704209044665,1.57627646608614,"CNKSR2","connector enhancer of kinase suppressor of Ras 2",TRUE
+"206731_at",0.842981138657703,0.436941818666445,0.791678988275132,-5.63893936422953,0.513039634484033,"CNKSR2","connector enhancer of kinase suppressor of Ras 2",TRUE
+"1554607_at",0.981927697474733,0.913298651542953,0.110128807856818,-5.93377793251834,0.0761361070452491,"CNKSR2","connector enhancer of kinase suppressor of Ras 2",TRUE
+"227481_at",0.948962238903406,0.769725014809557,0.296347062922012,-5.89699911762034,0.323869342540267,"CNKSR3","CNKSR family member 3",TRUE
+"237302_at",0.961690794738111,0.826340237668573,0.222009252944923,-5.91570553332856,0.273987805072514,"CNKSR3","CNKSR family member 3",TRUE
+"242394_at",0.984810537070054,0.925578790185819,-0.0944778463547612,-5.93533685930955,-0.0505779183069341,"CNKSR3","CNKSR family member 3",TRUE
+"1569331_at",0.98693003519805,0.939832284863341,0.0763418545590007,-5.93684523709307,0.0659212050667626,"CNKSR3","CNKSR family member 3",TRUE
+"203951_at",0.868045863234681,0.501915122195589,0.682631485290809,-5.71523249435714,0.724443930521165,"CNN1","calponin 1",TRUE
+"201605_x_at",0.768852835478002,0.272773737696225,1.12465060720682,-5.34171736647185,0.677680924301288,"CNN2","calponin 2",TRUE
+"228297_at",0.851319596585235,0.454836166779696,0.760734062327803,-5.66167587918591,1.1139050992208,"CNN3","calponin 3",TRUE
+"201445_at",0.955816406528307,0.798453968821218,0.258438641895793,-5.90720453284645,0.379389181344138,"CNN3","calponin 3",TRUE
+"220166_at",0.895457620469779,0.574346178006887,0.570099554574594,-5.78260927181203,0.263641105165318,"CNNM1","cyclin and CBS domain divalent metal cation transport mediator 1",TRUE
+"1554523_a_at",0.923376218980614,0.671029462407407,-0.43044582382603,-5.84983939087106,-0.115130186893305,"CNNM2","cyclin and CBS domain divalent metal cation transport mediator 2",TRUE
+"209874_x_at",0.93089781226267,0.69390187745841,0.398739594424876,-5.8625390292633,0.116541499765175,"CNNM2","cyclin and CBS domain divalent metal cation transport mediator 2",TRUE
+"206818_s_at",0.951810226174863,0.779049104842966,-0.28399781929708,-5.90047569257514,-0.0796400859399302,"CNNM2","cyclin and CBS domain divalent metal cation transport mediator 2",TRUE
+"1554522_at",0.997325121479245,0.986427931686435,-0.0172039010951538,-5.93953932365065,-0.0154277002090151,"CNNM2","cyclin and CBS domain divalent metal cation transport mediator 2",TRUE
+"220739_s_at",0.933609099853387,0.706157355904187,0.38192245179146,-5.86888678317966,0.113516671121561,"CNNM3","cyclin and CBS domain divalent metal cation transport mediator 3",TRUE
+"218900_at",0.806216644294069,0.346743198730225,-0.961365938281765,-5.49928277223247,-0.738690321473474,"CNNM4","cyclin and CBS domain divalent metal cation transport mediator 4",TRUE
+"200861_at",0.821424121108148,0.382986943111916,-0.890078010192191,-5.56100863725066,-0.323088040661158,"CNOT1","CCR4-NOT transcription complex subunit 1",TRUE
+"1554052_at",0.870808709484996,0.510377700844647,0.669046188980498,-5.7239834786465,0.231470194886304,"CNOT1","CCR4-NOT transcription complex subunit 1",TRUE
+"200860_s_at",0.889389445320988,0.557065731820171,0.596228110678686,-5.76800600895224,0.16969086490518,"CNOT1","CCR4-NOT transcription complex subunit 1",TRUE
+"223219_s_at",0.759884556197805,0.257728779110476,1.16167630335146,-5.3029384447996,0.384594287466312,"CNOT10","CCR4-NOT transcription complex subunit 10",TRUE
+"224695_at",0.955966019701688,0.801138532663779,-0.254916860627724,-5.90808231875293,-0.0655347787216947,"CNOT11","CCR4-NOT transcription complex subunit 11",TRUE
+"222182_s_at",0.777546747893206,0.296482417704407,-1.06921732255442,-5.39769128586747,-0.460196343703736,"CNOT2","CCR4-NOT transcription complex subunit 2",TRUE
+"217798_at",0.7994347047598,0.334892621519329,-0.985762640723236,-5.4771591670493,-0.392589492677192,"CNOT2","CCR4-NOT transcription complex subunit 2",TRUE
+"222181_at",0.859675188316647,0.47781120818842,-0.7220573823837,-5.68888617213684,-0.33866260227946,"CNOT2","CCR4-NOT transcription complex subunit 2",TRUE
+"233054_at",0.913123070637484,0.635116075659939,0.48116621312637,-5.82754298681823,0.348296822946044,"CNOT2","CCR4-NOT transcription complex subunit 2",TRUE
+"203239_s_at",0.623667408398064,0.0953354986774144,-1.74222304235137,-4.56042612400782,-0.484758704803665,"CNOT3","CCR4-NOT transcription complex subunit 3",TRUE
+"229143_at",0.742923871959998,0.233138779767193,-1.22581366407942,-5.23317060069384,-0.420428982845158,"CNOT3","CCR4-NOT transcription complex subunit 3",TRUE
+"211141_s_at",0.909253608893833,0.62329591380657,-0.498137168160339,-5.81954070383495,-0.157907476857501,"CNOT3","CCR4-NOT transcription complex subunit 3",TRUE
+"203291_at",0.784552021081681,0.308141596266781,-1.04311882337948,-5.42316812891745,-0.331066052771497,"CNOT4","CCR4-NOT transcription complex subunit 4",TRUE
+"210204_s_at",0.827866702343255,0.397214999175101,0.863312245976109,-5.58304845222453,0.272408984895776,"CNOT4","CCR4-NOT transcription complex subunit 4",TRUE
+"210866_s_at",0.943631120237335,0.747877137439788,0.325472479485217,-5.88821904588916,0.103638233736685,"CNOT4","CCR4-NOT transcription complex subunit 4",TRUE
+"210867_at",0.973071267819624,0.870207958206359,-0.165298492208341,-5.92638392283998,-0.0591617843194907,"CNOT4","CCR4-NOT transcription complex subunit 4",TRUE
+"210203_at",0.974138689437749,0.874257180649673,0.160094526846245,-5.92720763213099,0.0761424798331829,"CNOT4","CCR4-NOT transcription complex subunit 4",TRUE
+"217970_s_at",0.442846733327149,0.0206378322179712,-2.49259138859994,-3.29622808906824,-0.705230091638361,"CNOT6","CCR4-NOT transcription complex subunit 6",TRUE
+"222476_at",0.620912785033482,0.0905594006739,-1.76958443756663,-4.51972723813512,-0.514633300578744,"CNOT6","CCR4-NOT transcription complex subunit 6",TRUE
+"1553266_at",0.856857560656867,0.47129746873792,0.73290878069975,-5.68138778966436,0.703244944622885,"CNOT6L","CCR4-NOT transcription complex subunit 6 like",TRUE
+"1553267_a_at",0.869971289491322,0.508016369848093,0.672824110879337,-5.72156682368212,0.609937963099518,"CNOT6L","CCR4-NOT transcription complex subunit 6 like",TRUE
+"238438_at",0.97689149311934,0.889543622583588,-0.140488230269174,-5.93007491335935,-0.0494129340172442,"CNOT6L","CCR4-NOT transcription complex subunit 6 like",TRUE
+"227119_at",0.979347742195592,0.900420399771136,-0.126572459751468,-5.9318834544254,-0.0527633504615483,"CNOT6L","CCR4-NOT transcription complex subunit 6 like",TRUE
+"226153_s_at",0.990810941805126,0.955679891355004,0.0562080172556883,-5.93814479928278,0.0203251120746177,"CNOT6L","CCR4-NOT transcription complex subunit 6 like",TRUE
+"1558372_at",0.67368843181164,0.140132629608099,1.5301503571076,-4.85942081635403,1.6784166302423,"CNOT7","CCR4-NOT transcription complex subunit 7",TRUE
+"1552344_s_at",0.822173415758858,0.386287004184459,0.88381305799251,-5.56622336147211,0.369340030237142,"CNOT7","CCR4-NOT transcription complex subunit 7",TRUE
+"233019_at",0.833947935066508,0.411747764002369,0.836603910089068,-5.60441630135834,0.333929738725383,"CNOT7","CCR4-NOT transcription complex subunit 7",TRUE
+"225053_at",0.950214160603623,0.773833112785004,-0.290900429918528,-5.89855055045071,-0.0861032473925682,"CNOT7","CCR4-NOT transcription complex subunit 7",TRUE
+"218250_s_at",0.985736911886368,0.931217141944998,0.0873001337675401,-5.93597210164527,0.0269950045668192,"CNOT7","CCR4-NOT transcription complex subunit 7",TRUE
+"1558373_s_at",0.993474831312851,0.969309850978401,-0.0389109676453395,-5.93894606319492,-0.0341777135006192,"CNOT7","CCR4-NOT transcription complex subunit 7",TRUE
+"202164_s_at",0.728385463227073,0.20882921629837,-1.29447876436953,-5.15490322136778,-0.482947548650925,"CNOT8","CCR4-NOT transcription complex subunit 8",TRUE
+"202163_s_at",0.830635993561085,0.403513823317736,-0.85166078932342,-5.59244710907521,-0.260560827590128,"CNOT8","CCR4-NOT transcription complex subunit 8",TRUE
+"202162_s_at",0.869971289491322,0.507915899219026,-0.672985073022407,-5.72146357034959,-0.2452605503588,"CNOT8","CCR4-NOT transcription complex subunit 8",TRUE
+"213179_at",0.64513208805899,0.116306885718041,-1.63438910444698,-4.71618004464833,-0.37530758404449,"CNOT9","CCR4-NOT transcription complex subunit 9",TRUE
+"1553510_s_at",0.71854285173343,0.194266125913554,1.33862837485065,-5.10266855383916,0.378706043741508,"CNOT9","CCR4-NOT transcription complex subunit 9",TRUE
+"1554080_at",0.778170595080965,0.29760488601999,1.06667326755625,-5.40019956529199,0.384970420399728,"CNOT9","CCR4-NOT transcription complex subunit 9",TRUE
+"213903_s_at",0.835952408568777,0.415929700791582,0.829029827231017,-5.61036176098972,0.585007518733658,"CNOT9","CCR4-NOT transcription complex subunit 9",TRUE
+"236684_at",0.892895911526563,0.566453700887588,-0.581982433827927,-5.77604642706652,-0.495770969893053,"CNOT9","CCR4-NOT transcription complex subunit 9",TRUE
+"213098_at",0.92733914121058,0.68191453625859,-0.415302757458079,-5.85602396912311,-0.109493868358578,"CNOT9","CCR4-NOT transcription complex subunit 9",TRUE
+"208912_s_at",0.855463536305195,0.46868659177784,0.737283078448175,-5.67833509104674,0.334122950363462,"CNP","2',3'-cyclic nucleotide 3' phosphodiesterase",TRUE
+"1557943_at",0.904092974845832,0.606283839464516,0.522827078863956,-5.80741554956949,0.249969984261761,"CNP","2',3'-cyclic nucleotide 3' phosphodiesterase",TRUE
+"200070_at",0.657571067962164,0.12628834400985,-1.58873843885466,-4.77981845784518,-0.475330867343622,"CNPPD1","cyclin Pas1/PHO80 domain containing 1",TRUE
+"207511_s_at",0.660068911122272,0.128031929787535,-1.58107517248034,-4.7903638003302,-0.791551004149119,"CNPPD1","cyclin Pas1/PHO80 domain containing 1",TRUE
+"1559283_a_at",0.952339611416198,0.781897330480533,0.280234566046077,-5.90150594448496,0.21311277971324,"CNPY1","canopy FGF signaling regulator 1",TRUE
+"209796_s_at",0.537362711897029,0.0435688870935442,-2.14049774196448,-3.92492805264958,-0.78189566179713,"CNPY2","canopy FGF signaling regulator 2",TRUE
+"202857_at",0.576321960932338,0.061211390265166,-1.97207535915204,-4.20453843219654,-0.813270044875305,"CNPY2","canopy FGF signaling regulator 2",TRUE
+"209797_at",0.596889565909742,0.0731217775271058,-1.88140390936997,-4.34864654560651,-0.641368423130608,"CNPY2","canopy FGF signaling regulator 2",TRUE
+"1557798_at",0.979124488698146,0.89866572586778,0.128815588572799,-5.93160465054747,0.0523915708326443,"CNPY2","canopy FGF signaling regulator 2",TRUE
+"228369_at",0.90344422113846,0.604193793450606,0.525882909963443,-5.80587509855334,0.168968098959551,"CNPY3","canopy FGF signaling regulator 3",TRUE
+"217931_at",0.920295529438727,0.660751942643427,-0.444838133271256,-5.84375985223354,-0.16038335906463,"CNPY3","canopy FGF signaling regulator 3",TRUE
+"1552977_a_at",0.937409179150458,0.722182037076495,-0.360100275794892,-5.87672153208682,-0.122077357206965,"CNPY3","canopy FGF signaling regulator 3",TRUE
+"1556389_at",0.997608949249317,0.987986637188572,0.0152279220729231,-5.93957053650057,0.00819640209144268,"CNPY3","canopy FGF signaling regulator 3",TRUE
+"227313_at",0.774230543658252,0.289999074533239,-1.0840483121339,-5.38296255695568,-0.450201194910749,"CNPY4","canopy FGF signaling regulator 4",TRUE
+"217700_at",0.852371612067119,0.458036480865162,-0.755277900062827,-5.66559593200934,-0.639255710357108,"CNPY4","canopy FGF signaling regulator 4",TRUE
+"207940_x_at",0.45838672386873,0.0228375937049551,2.4460725700224,-3.38236572480837,1.29600978535643,"CNR1","cannabinoid receptor 1",TRUE
+"208243_s_at",0.623667408398064,0.0948147146451666,1.7451486935999,-4.55609670129438,0.62703987010395,"CNR1","cannabinoid receptor 1",TRUE
+"213436_at",0.655977008603425,0.12438067943652,1.59722438076124,-4.76809465996447,1.55829635509881,"CNR1","cannabinoid receptor 1",TRUE
+"1560225_at",0.868313695469383,0.502677392318245,-0.681402522587113,-5.71603105375666,-0.281636752925467,"CNR1","cannabinoid receptor 1",TRUE
+"206586_at",0.683017520100356,0.151530041996372,1.48539252381464,-4.91862808747347,0.397845518433474,"CNR2","cannabinoid receptor 2",TRUE
+"226751_at",0.822873158500962,0.388730408446814,0.879196886338391,-5.57004384540209,0.712316273336097,"CNRIP1","cannabinoid receptor interacting protein 1",TRUE
+"225550_at",0.42796179417767,0.018475068202756,-2.54306844828629,-3.20180323951785,-0.852333408524845,"CNST","consortin, connexin sorting protein",TRUE
+"225551_at",0.463552233135475,0.0236884305327941,-2.42918907861734,-3.41341286303788,-0.845971521850897,"CNST","consortin, connexin sorting protein",TRUE
+"1554660_a_at",0.663129351367592,0.13103130525269,-1.56809303744894,-4.80813727062731,-0.832440814833195,"CNST","consortin, connexin sorting protein",TRUE
+"1554661_s_at",0.726696341943087,0.206745575392712,-1.30064561616237,-5.14769608507525,-0.339367077036243,"CNST","consortin, connexin sorting protein",TRUE
+"231463_at",0.677013732819214,0.144068915183393,-1.51436637837243,-4.88046078022247,-1.14628386270985,"CNTD1","cyclin N-terminal domain containing 1",TRUE
+"220323_at",0.768852835478002,0.272214686260084,-1.12599924100921,-5.34032431952641,-0.966247633785272,"CNTD2","cyclin N-terminal domain containing 2",TRUE
+"208597_at",0.735677568529031,0.220804186548905,1.25993000434764,-5.19473999205656,0.4635426686985,"CNTF","ciliary neurotrophic factor",TRUE
+"205723_at",0.937623890519979,0.723475455690472,0.358346805551348,-5.87733132815332,0.118272154892094,"CNTFR","ciliary neurotrophic factor receptor",TRUE
+"1556771_a_at",0.51470556386048,0.0349662879433211,-2.24645384112925,-3.74164061704787,-1.52213710256476,"CNTFR-AS1","CNTFR antisense RNA 1",TRUE
+"1561590_a_at",0.859502367311367,0.477316545537773,0.722878398110452,-5.68832256239449,0.409616521372399,"CNTFR-AS1","CNTFR antisense RNA 1",TRUE
+"241696_at",0.807944276806637,0.349703946581617,0.9553597667473,-5.50465162965632,0.939418276737557,"CNTLN","centlein",TRUE
+"220095_at",0.861113073516266,0.4812837642208,0.716307729726557,-5.6928161134497,0.738497406514155,"CNTLN","centlein",TRUE
+"1559005_s_at",0.863569008901048,0.488854510467653,0.70385551795387,-5.70122475787867,0.685537802104759,"CNTLN","centlein",TRUE
+"239989_at",0.914910510855952,0.641505606330042,-0.47205200913324,-5.83172864453965,-0.455590517843842,"CNTLN","centlein",TRUE
+"211203_s_at",0.663129351367592,0.131103649144967,1.56778296953269,-4.80856037020579,1.61364864147148,"CNTN1","contactin 1",TRUE
+"227209_at",0.690823350461169,0.160384726507769,1.45247649867021,-4.96126610516947,1.57551365957495,"CNTN1","contactin 1",TRUE
+"1554784_at",0.759759632795787,0.257565146284723,1.16208767157559,-5.30250139784069,0.910535476894519,"CNTN1","contactin 1",TRUE
+"227202_at",0.982090256251837,0.91392715087071,0.109327138838511,-5.9338635723366,0.167941179852685,"CNTN1","contactin 1",TRUE
+"206970_at",0.937462538530338,0.722414333785365,0.359785269661653,-5.87683129690031,0.169078347760171,"CNTN2","contactin 2",TRUE
+"230045_at",0.962741248200658,0.830537109353094,-0.216554368208294,-5.91686804621175,-0.114871063097957,"CNTN2","contactin 2",TRUE
+"229831_at",0.794443786143158,0.326388160478564,1.00363922166455,-5.46062806124257,1.5161131055478,"CNTN3","contactin 3",TRUE
+"237177_at",0.623322898783689,0.0939858066314172,-1.74983382017732,-4.54915239246172,-1.3607496938604,"CNTN4","contactin 4",TRUE
+"229084_at",0.808257777979515,0.35066897200404,-0.953409578101701,-5.50638826142624,-1.26030047119815,"CNTN4","contactin 4",TRUE
+"244632_at",0.722442821599878,0.199060775546469,1.32381604332262,-5.12035815722587,1.50611362737513,"CNTN5","contactin 5",TRUE
+"207452_s_at",0.991689960875868,0.961317611018389,-0.049051667863391,-5.9385116426004,-0.0350397712157706,"CNTN5","contactin 5",TRUE
+"207195_at",0.554383599468784,0.0507784356728384,2.0653914696693,-4.05146458378894,1.35473831354606,"CNTN6","contactin 6",TRUE
+"219400_at",0.864079461576774,0.490927693298314,0.700465037141622,-5.70348991743779,0.485672020951495,"CNTNAP1","contactin associated protein 1",TRUE
+"219301_s_at",0.656641058207682,0.124665833556499,-1.59594905651028,-4.76985969606792,-2.21650708916731,"CNTNAP2","contactin associated protein-like 2",TRUE
+"219300_s_at",0.691576963476801,0.161207338008513,-1.44949385554495,-4.96509137854295,-1.69993702904865,"CNTNAP2","contactin associated protein-like 2",TRUE
+"215145_s_at",0.819780516863333,0.377550612214713,-0.900476136338231,-5.55227835785765,-1.39424123737871,"CNTNAP2","contactin associated protein-like 2",TRUE
+"219302_s_at",0.94895689004559,0.769431369688828,-0.29673673467524,-5.89688702864117,-0.32315021791418,"CNTNAP2","contactin associated protein-like 2",TRUE
+"233202_at",0.369429132228615,0.0109657652443149,2.77635172336676,-2.75354257458265,3.13554998460164,"CNTNAP3","contactin associated protein-like 3",TRUE
+"244065_at",0.327864702134751,0.00773286686734335,2.92900815765035,-2.45087672195474,2.95598486263767,"CNTNAP3B///CNTNAP3","contactin associated protein-like 3B///contactin associated protein-like 3",TRUE
+"223796_at",0.360736459722853,0.0103220967494748,2.8029721814223,-2.70125379923027,3.05993075490143,"CNTNAP3B///CNTNAP3P2///CNTNAP3","contactin associated protein-like 3B///contactin associated protein-like 3 pseudogene 2///contactin associated protein-like 3",TRUE
+"220436_at",0.603702127972549,0.0779846669400238,1.848073555015,-4.4004254441867,1.12039881500407,"CNTNAP3P2","contactin associated protein-like 3 pseudogene 2",TRUE
+"1553442_a_at",0.451020270465914,0.0215947631474584,2.47181468001321,-3.33480630768759,1.80247464119035,"CNTNAP4","contactin associated protein like 4",TRUE
+"1553441_at",0.566623884595032,0.0570438437287854,2.00751522968417,-4.14695871138989,2.53804444983741,"CNTNAP4","contactin associated protein like 4",TRUE
+"232388_at",0.575986890549489,0.061070205009466,1.97324046632056,-4.20265646856781,0.709886976015262,"CNTNAP4","contactin associated protein like 4",TRUE
+"1554377_a_at",0.947938416246738,0.763107347319169,0.305140317838876,-5.89443421207466,0.165357428777556,"CNTNAP4","contactin associated protein like 4",TRUE
+"1553418_a_at",0.864894115958506,0.493637615646754,0.69604560576818,-5.70642685017182,0.561113315209687,"CNTNAP5","contactin associated protein like 5",TRUE
+"1553013_at",0.90344422113846,0.604208835292544,0.525860899382513,-5.8058862253896,0.26661287165854,"CNTNAP5","contactin associated protein like 5",TRUE
+"242916_at",0.663566587754224,0.131520026985229,1.56600111345488,-4.81099050715475,1.22040609147444,"CNTRL","centriolin",TRUE
+"205642_at",0.721297082581089,0.197504135771769,1.32859414233801,-5.11467001403378,0.411275861577616,"CNTRL","centriolin",TRUE
+"234694_at",0.759737799622618,0.257539650264392,1.16215178528408,-5.30243326975682,0.426357053469032,"CNTROB","centrobin, centriole duplication and spindle assembly protein",TRUE
+"234688_x_at",0.7994347047598,0.334723544017139,0.986114972879518,-5.47683596249941,0.748780516783198,"CNTROB","centrobin, centriole duplication and spindle assembly protein",TRUE
+"231884_at",0.805670827550507,0.345093829179795,0.964726988023152,-5.49626493940124,0.561453498117473,"CNTROB","centrobin, centriole duplication and spindle assembly protein",TRUE
+"228633_s_at",0.863739823286196,0.489297647208876,0.703130118576823,-5.70171026963252,0.183631484797917,"CNTROB","centrobin, centriole duplication and spindle assembly protein",TRUE
+"232330_at",0.83364851657447,0.411220859478984,0.837561658962755,-5.6036608937267,0.498906415002971,"COA1","cytochrome c oxidase assembly factor 1 homolog",TRUE
+"209445_x_at",0.906989884330247,0.615468150003626,-0.509457849006789,-5.81405214122422,-0.165159845050386,"COA1","cytochrome c oxidase assembly factor 1 homolog",TRUE
+"239490_at",0.926294422392192,0.679824714903182,0.418202310092997,-5.85485661625067,0.17630451937632,"COA1","cytochrome c oxidase assembly factor 1 homolog",TRUE
+"206497_at",0.969859842767097,0.855972491091998,0.183631742722794,-5.92327274497063,0.0747611464039162,"COA1","cytochrome c oxidase assembly factor 1 homolog",TRUE
+"218026_at",0.720018659171833,0.195896489223979,-1.33355982331303,-5.10874028990463,-0.356526386965562,"COA3","cytochrome c oxidase assembly factor 3",TRUE
+"236998_at",0.956734254923335,0.804017367400109,-0.251143878706133,-5.90900943495801,-0.140714907995126,"COA3","cytochrome c oxidase assembly factor 3",TRUE
+"220647_s_at",0.741186481976394,0.231438088679364,-1.2304346935858,-5.22801841896627,-0.402812445757718,"COA4","cytochrome c oxidase assembly factor 4 homolog",TRUE
+"225409_at",0.643082025527735,0.113311152435302,-1.64873049880546,-4.6959012142196,-0.490528608857126,"COA5","cytochrome c oxidase assembly factor 5",TRUE
+"225410_at",0.986418104647939,0.935957138653958,-0.0812696910209994,-5.93646705630576,-0.0301791840087589,"COA5","cytochrome c oxidase assembly factor 5",TRUE
+"225638_at",0.961212424803935,0.823321073721909,0.225937666884369,-5.91485050594485,0.0785134012613966,"COA6","cytochrome c oxidase assembly factor 6",TRUE
+"222883_at",0.861113073516266,0.481315131270764,-0.716255904376429,-5.69285140062903,-0.243839326270965,"COA7","cytochrome c oxidase assembly factor 7 (putative)",TRUE
+"219420_s_at",0.971735822349954,0.864784936709743,0.172275385701188,-5.92523835730749,0.0468506580229597,"COA7","cytochrome c oxidase assembly factor 7 (putative)",TRUE
+"201913_s_at",0.980176424909863,0.906907161127368,-0.118285633236247,-5.93287103820946,-0.0518416517879317,"COASY","Coenzyme A synthase",TRUE
+"1552496_a_at",0.851319596585235,0.455366098202478,-0.759829000255216,-5.66232797942954,-1.06530259288702,"COBL","cordon-bleu WH2 repeat protein",TRUE
+"213050_at",0.92523595026689,0.676154655191581,-0.423303242675806,-5.85278361395431,-0.58123717507798,"COBL","cordon-bleu WH2 repeat protein",TRUE
+"229598_at",0.647754107214051,0.119006265433211,-1.62172967306059,-4.733967336104,-1.77067862864199,"COBLL1","cordon-bleu WH2 repeat protein like 1",TRUE
+"203642_s_at",0.714795139167042,0.190456507638792,-1.35060335237423,-5.08824673773198,-0.96083106630975,"COBLL1","cordon-bleu WH2 repeat protein like 1",TRUE
+"203641_s_at",0.815977292327875,0.366939980595011,-0.921059426994102,-5.53472054253267,-0.708788699636637,"COBLL1","cordon-bleu WH2 repeat protein like 1",TRUE
+"211032_at",0.936992192746977,0.718980441925317,-0.364445601742577,-5.87519771163157,-0.322306720696292,"COBLL1","cordon-bleu WH2 repeat protein like 1",TRUE
+"215393_s_at",0.95238233774064,0.782185279211563,-0.279854341099772,-5.90160927864698,-0.186655094014817,"COBLL1","cordon-bleu WH2 repeat protein like 1",TRUE
+"205229_s_at",0.403594301364014,0.014984845574192,2.63756106813974,-3.02249156358022,2.91494940459643,"COCH","cochlin",TRUE
+"1554242_a_at",0.425751189365875,0.0182020980312247,2.54982738734905,-3.189085966633,3.26904479117908,"COCH","cochlin",TRUE
+"1554241_at",0.631255973326775,0.102247881111695,-1.70462984925664,-4.61557551302024,-0.779543952825982,"COCH","cochlin",TRUE
+"230878_s_at",0.82706053436911,0.395643991282667,-0.866236768790066,-5.58067072493355,-0.625176176126366,"COG1","component of oligomeric golgi complex 1",TRUE
+"231813_s_at",0.899808883319249,0.593275253031774,0.541930382038018,-5.79764216280827,0.176097714784372,"COG1","component of oligomeric golgi complex 1",TRUE
+"227784_s_at",0.951163538450312,0.776862736857776,0.286889426220092,-5.89967480380826,0.129939572895974,"COG1","component of oligomeric golgi complex 1",TRUE
+"203073_at",0.610404195568275,0.0828095037807213,-1.81674550050957,-4.44849150900645,-0.594468505167358,"COG2","component of oligomeric golgi complex 2",TRUE
+"243608_at",0.764312283028184,0.264330549882242,1.14523847649913,-5.32029112075308,0.857155290645464,"COG2","component of oligomeric golgi complex 2",TRUE
+"223450_s_at",0.996168756168935,0.980846830117643,-0.0242797250667389,-5.93939635865336,-0.00852626717095717,"COG3","component of oligomeric golgi complex 3",TRUE
+"1554339_a_at",0.99886461451188,0.994865657374737,0.00650798526871567,-5.93966285176055,0.00263307422316039,"COG3","component of oligomeric golgi complex 3",TRUE
+"212189_s_at",0.54295328972902,0.0462186621666549,-2.11167734615141,-3.97382532721538,-0.713613188135312,"COG4","component of oligomeric golgi complex 4",TRUE
+"203630_s_at",0.70772084164277,0.179348646743612,1.38663217696974,-5.04421057471868,0.384732090221677,"COG5","component of oligomeric golgi complex 5",TRUE
+"203629_s_at",0.819018525257656,0.373099623665922,0.909063239639731,-5.54499796718559,0.320551071827822,"COG5","component of oligomeric golgi complex 5",TRUE
+"227089_at",0.940756067985891,0.734828242253837,0.343004304851902,-5.8825414540949,0.113235335636857,"COG5","component of oligomeric golgi complex 5",TRUE
+"232786_at",0.627092759817312,0.0988111085950606,-1.72304036039,-4.5886792763449,-1.02027067355037,"COG6","component of oligomeric golgi complex 6",TRUE
+"225769_at",0.92247975200053,0.668590839637659,0.433852327110047,-5.84841816279436,0.173613932860782,"COG6","component of oligomeric golgi complex 6",TRUE
+"213190_at",0.182130927283094,0.00170888277450805,-3.56701314713417,-1.12877385774386,-1.69649569369512,"COG7","component of oligomeric golgi complex 7",TRUE
+"227770_at",0.651332373348922,0.12092353073794,-1.61288348282632,-4.74633340869445,-0.562886885779106,"COG8","component of oligomeric golgi complex 8",TRUE
+"238863_x_at",0.862639573412331,0.486265233700376,-0.708101672003132,-5.69837322576414,-0.211126233157904,"COG8","component of oligomeric golgi complex 8",TRUE
+"219575_s_at",0.830635993561085,0.404107737790052,-0.850568212116714,-5.59332233487173,-0.352927175391578,"COG8///PDF","component of oligomeric golgi complex 8///peptide deformylase (mitochondrial)",TRUE
+"203654_s_at",0.804658857755908,0.343639402563138,-0.967699882705263,-5.4935876053591,-0.401536776703272,"COIL","coilin",TRUE
+"203653_s_at",0.841550580403629,0.433139331388631,-0.798354142178964,-5.63392291717843,-0.349711507505877,"COIL","coilin",TRUE
+"205941_s_at",0.896229101808264,0.579611540866136,-0.562218011606508,-5.78688982603462,-0.287510232096183,"COL10A1","collagen type X alpha 1 chain",TRUE
+"217428_s_at",0.941311073534434,0.737299795016499,-0.339675398098958,-5.88364215902356,-0.266270022822173,"COL10A1","collagen type X alpha 1 chain",TRUE
+"37892_at",0.558021698679157,0.052645900911145,2.0475033007232,-4.08117025815379,1.11131726729629,"COL11A1","collagen type XI alpha 1 chain",TRUE
+"229271_x_at",0.868220463162593,0.50225779660484,-0.682078881286715,-5.71559173740892,-0.633393630119731,"COL11A1","collagen type XI alpha 1 chain",TRUE
+"204320_at",0.925091998149497,0.675554976963137,0.424137804639605,-5.85244209928741,0.286004144757042,"COL11A1","collagen type XI alpha 1 chain",TRUE
+"213870_at",0.768852835478002,0.274047601703527,-1.12158511758446,-5.34487831574299,-1.06028155118506,"COL11A2","collagen type XI alpha 2 chain",TRUE
+"216993_s_at",0.875938621758472,0.524320569294049,0.646934345433016,-5.73786626544772,0.142633922944,"COL11A2","collagen type XI alpha 2 chain",TRUE
+"233109_at",0.863408882018863,0.487859698212025,-0.705485371840717,-5.70013215177366,-0.721900136133538,"COL12A1","collagen type XII alpha 1 chain",TRUE
+"231766_s_at",0.90998880119877,0.625294095491705,-0.495257953151513,-5.82091741846625,-0.744972162244656,"COL12A1","collagen type XII alpha 1 chain",TRUE
+"225664_at",0.93032716386748,0.691964792772632,-0.401408306445634,-5.86150693806629,-0.572512081326501,"COL12A1","collagen type XII alpha 1 chain",TRUE
+"231879_at",0.932625096890813,0.702384785812405,-0.38708706300751,-5.86696603966361,-0.572098274292019,"COL12A1","collagen type XII alpha 1 chain",TRUE
+"234951_s_at",0.990623482682449,0.952647825930336,-0.060058048532561,-5.93792681173927,-0.0448461226439276,"COL12A1","collagen type XII alpha 1 chain",TRUE
+"211343_s_at",0.498206796273596,0.0310989090630509,2.30206918895326,-3.64330995500306,3.10588911089616,"COL13A1","collagen type XIII alpha 1 chain",TRUE
+"208535_x_at",0.602212332334799,0.0771221836437304,1.85385035161223,-4.39149816593586,1.23308559530564,"COL13A1","collagen type XIII alpha 1 chain",TRUE
+"211809_x_at",0.774230543658252,0.287368233535795,1.09013448880433,-5.37686595751702,0.623303938485133,"COL13A1","collagen type XIII alpha 1 chain",TRUE
+"216865_at",0.676468346171966,0.143310082636029,1.51738142942392,-4.87645516838405,0.71651007997666,"COL14A1","collagen type XIV alpha 1 chain",TRUE
+"212865_s_at",0.740476003158683,0.22928881184872,-1.23631161822521,-5.22144183252518,-1.14423643969569,"COL14A1","collagen type XIV alpha 1 chain",TRUE
+"228750_at",0.783844746433788,0.306779657382643,-1.04613089500152,-5.42025666913909,-0.880649643126932,"COL14A1","collagen type XIV alpha 1 chain",TRUE
+"216866_s_at",0.937623890519979,0.723757452918148,-0.357964657858838,-5.87746383567745,-0.318112957069074,"COL14A1","collagen type XIV alpha 1 chain",TRUE
+"203477_at",0.96200396340887,0.827522999305237,0.220471268309141,-5.91603621328102,0.168282468180659,"COL15A1","collagen type XV alpha 1 chain",TRUE
+"204345_at",0.42796179417767,0.0184990994854797,2.54247789517995,-3.20291357817402,2.12135525731695,"COL16A1","collagen type XVI alpha 1 chain",TRUE
+"204636_at",0.0205044955663445,1.50010027005721e-05,5.51264746967461,3.02723331762227,4.69936371609025,"COL17A1","collagen type XVII alpha 1 chain",TRUE
+"209082_s_at",0.872326507573924,0.515482343542861,0.660912419091762,-5.72914222692573,0.513015037635961,"COL18A1","collagen type XVIII alpha 1 chain",TRUE
+"209081_s_at",0.888312537451395,0.554312586630791,0.600429424358837,-5.76559886157242,0.858187445015362,"COL18A1","collagen type XVIII alpha 1 chain",TRUE
+"1564017_at",0.596440653845378,0.072980118412905,-1.88240352592186,-4.34708355293837,-0.719750127878481,"COL18A1-AS1","COL18A1 antisense RNA 1",TRUE
+"211011_at",0.781332102816274,0.30298679915703,1.05456944293935,-5.41205982348838,0.815824343184169,"COL19A1","collagen type XIX alpha 1 chain",TRUE
+"217430_x_at",0.627092759817312,0.0982951711063326,1.72585114818997,-4.58455396759919,0.565800175394005,"COL1A1","collagen type I alpha 1 chain",TRUE
+"202311_s_at",0.727286289873957,0.207522059629247,1.29834188568087,-5.15039183146711,0.769966697419403,"COL1A1","collagen type I alpha 1 chain",TRUE
+"1556499_s_at",0.758920166935337,0.25628163496037,1.16532112387319,-5.29906138143494,0.851274922006482,"COL1A1","collagen type I alpha 1 chain",TRUE
+"202312_s_at",0.846311252145305,0.444314245568363,0.778837925359752,-5.64847799952599,0.443153038468715,"COL1A1","collagen type I alpha 1 chain",TRUE
+"202310_s_at",0.9181984176728,0.652741429973288,0.456122211146286,-5.83885612124842,0.302282309736109,"COL1A1","collagen type I alpha 1 chain",TRUE
+"202404_s_at",0.523176111047337,0.0387051837090033,2.1977857217649,-3.82650340947159,3.19807642360881,"COL1A2","collagen type I alpha 2 chain",TRUE
+"202403_s_at",0.623667408398064,0.0947589589076715,1.74546273179644,-4.55563166339254,1.87758822726011,"COL1A2","collagen type I alpha 2 chain",TRUE
+"229218_at",0.908466056355731,0.619471642196617,0.503659578355779,-5.81687832919826,0.472995891088162,"COL1A2","collagen type I alpha 2 chain",TRUE
+"232733_s_at",0.971216837324271,0.862845344329775,0.174772842532159,-5.92481681307331,0.122981993194032,"COL20A1","collagen type XX alpha 1 chain",TRUE
+"232638_at",0.998870448604467,0.995377571763816,0.00585910505246865,-5.93966676031817,0.00507395106202191,"COL20A1","collagen type XX alpha 1 chain",TRUE
+"208096_s_at",0.919177722942441,0.655870817700968,-0.451706892628811,-5.84078923371338,-0.634931215122964,"COL21A1","collagen type XXI alpha 1 chain",TRUE
+"242326_at",0.567292616148537,0.0573061460519242,2.00521799924272,-4.15071190875964,0.763067565818042,"COL22A1","collagen type XXII alpha 1 chain",TRUE
+"243301_at",0.789795896476304,0.317952947334486,1.02169273935228,-5.44366012740001,0.646032413435033,"COL22A1","collagen type XXII alpha 1 chain",TRUE
+"228873_at",0.901910595357431,0.600135516592569,0.53183101021193,-5.80285158854401,0.282513060487074,"COL22A1","collagen type XXII alpha 1 chain",TRUE
+"229168_at",0.645072069975909,0.115480305258875,1.63831486351733,-4.71064250406807,0.839671687416035,"COL23A1","collagen type XXIII alpha 1 chain",TRUE
+"238732_at",0.726636642789909,0.206205613353275,-1.30225157482382,-5.14581445072137,-1.23178933858215,"COL24A1","collagen type XXIV alpha 1 chain",TRUE
+"224389_s_at",0.682381152782224,0.149843038322878,-1.49184009693174,-4.91018589663734,-1.00965272488948,"COL25A1","collagen type XXV alpha 1 chain",TRUE
+"224388_s_at",0.689985677226298,0.159449941104024,1.45588090083771,-4.95689210778113,0.60805388036738,"COL25A1","collagen type XXV alpha 1 chain",TRUE
+"1555253_at",0.9181984176728,0.652628696045535,0.456281441214487,-5.83878606288604,0.439624270745691,"COL25A1","collagen type XXV alpha 1 chain",TRUE
+"233894_x_at",0.609532363331105,0.0817949510701475,-1.82319907891909,-4.43863812762084,-0.737959475948712,"COL26A1","collagen type XXVI alpha 1 chain",TRUE
+"229080_at",0.979588787486838,0.901501619938576,-0.125190588290902,-5.93205277638703,-0.119136611435597,"COL26A1","collagen type XXVI alpha 1 chain",TRUE
+"225293_at",0.6603959121103,0.128346903741821,1.57970008573165,-4.79225182557185,0.909456375855993,"COL27A1","collagen type XXVII alpha 1 chain",TRUE
+"225288_at",0.682825347106105,0.150899121008092,1.48779696950819,-4.9154832444348,1.47446706183599,"COL27A1","collagen type XXVII alpha 1 chain",TRUE
+"1564008_at",0.767727587789514,0.269936899157812,-1.13151513382208,-5.3346114237139,-0.566012135271388,"COL27A1","collagen type XXVII alpha 1 chain",TRUE
+"230603_at",0.9330573785522,0.704317821075011,0.384439426754025,-5.86795388539196,0.203416574574526,"COL27A1","collagen type XXVII alpha 1 chain",TRUE
+"225292_at",0.968066640321622,0.850070654155607,0.191251025576065,-5.9218838812824,0.112050730799324,"COL27A1","collagen type XXVII alpha 1 chain",TRUE
+"239921_at",0.892892804749035,0.566415972398259,-0.582039439980348,-5.77601462700527,-0.563756579185196,"COL28A1","collagen type XXVIII alpha 1 chain",TRUE
+"242345_at",0.975449397348071,0.882825270982048,-0.149097737939871,-5.92886179816247,-0.122552084739563,"COL28A1","collagen type XXVIII alpha 1 chain",TRUE
+"213492_at",0.624374299616567,0.0958747737476504,-1.73920788968326,-4.56488236188303,-2.1395846603965,"COL2A1","collagen type II alpha 1 chain",TRUE
+"217404_s_at",0.924812035112346,0.674801531542425,-0.425186796157946,-5.85201189933629,-0.666462723937536,"COL2A1","collagen type II alpha 1 chain",TRUE
+"215077_at",0.673870607802125,0.140468918817833,-1.52878775896225,-4.86124399929511,-0.953330886715467,"COL3A1","collagen type III alpha 1 chain",TRUE
+"201852_x_at",0.77480482329936,0.291239230990164,-1.08119311436381,-5.38581215182837,-1.63755622004987,"COL3A1","collagen type III alpha 1 chain",TRUE
+"232458_at",0.889564089063817,0.557746810130516,0.595190452634258,-5.76859802147543,0.418520374859555,"COL3A1","collagen type III alpha 1 chain",TRUE
+"215076_s_at",0.906845308365483,0.61501076330538,-0.510121407536636,-5.81372669804118,-0.902812431095736,"COL3A1","collagen type III alpha 1 chain",TRUE
+"211161_s_at",0.946277807642742,0.756686383792123,-0.3136957311944,-5.89186735633524,-0.577377160577761,"COL3A1","collagen type III alpha 1 chain",TRUE
+"211981_at",0.296090407530139,0.00530123884497394,3.09143895911231,-2.12201183759182,4.0601149027165,"COL4A1","collagen type IV alpha 1 chain",TRUE
+"211980_at",0.421893198787204,0.0175856351172572,2.56544711362752,-3.15963139119404,3.11300463295488,"COL4A1","collagen type IV alpha 1 chain",TRUE
+"211966_at",0.58092861580092,0.0635276121421802,1.95329264144943,-4.23477327288643,2.34820455752335,"COL4A2","collagen type IV alpha 2 chain",TRUE
+"211964_at",0.583823590956325,0.064709116802841,1.9439433742597,-4.24974928405577,2.60243648170509,"COL4A2","collagen type IV alpha 2 chain",TRUE
+"222073_at",0.615821255316333,0.0865687042956798,1.79341450510203,-4.48390269166845,1.31713820807992,"COL4A3","collagen type IV alpha 3 chain",TRUE
+"216893_s_at",0.663129351367592,0.131065616009727,1.5679459629187,-4.80833796766304,1.27095772313889,"COL4A3","collagen type IV alpha 3 chain",TRUE
+"214641_at",0.707694888507328,0.179172736014445,1.38721680367001,-5.04348807650825,1.01868444380018,"COL4A3","collagen type IV alpha 3 chain",TRUE
+"216898_s_at",0.73957587762701,0.227976327176994,1.23992106919945,-5.21738928496645,1.01434335262517,"COL4A3","collagen type IV alpha 3 chain",TRUE
+"216367_at",0.883410339479976,0.541483091959562,0.620153545425855,-5.75407991527625,0.400678363736392,"COL4A3","collagen type IV alpha 3 chain",TRUE
+"216896_at",0.974982245454858,0.877754446703449,0.155603567971413,-5.92789735543752,0.127438718049346,"COL4A3","collagen type IV alpha 3 chain",TRUE
+"216368_s_at",0.97771449920834,0.892341989620877,0.136905391384487,-5.93055853577971,0.053625537819805,"COL4A3","collagen type IV alpha 3 chain",TRUE
+"223465_at",0.627021415091472,0.0975509733287221,-1.72992774114021,-4.57856197828131,-0.707804880896788,"COL4A3BP","collagen type IV alpha 3 binding protein",TRUE
+"226277_at",0.756601922352523,0.252027197341452,-1.17612578790886,-5.2875057897826,-0.477849063715437,"COL4A3BP","collagen type IV alpha 3 binding protein",TRUE
+"219625_s_at",0.793016712530949,0.324856518928814,-1.00689296684581,-5.45759020916512,-0.356675433209817,"COL4A3BP","collagen type IV alpha 3 binding protein",TRUE
+"223466_x_at",0.816966928109267,0.369190025218216,-0.916661964665853,-5.53850237619524,-0.346816415444817,"COL4A3BP","collagen type IV alpha 3 binding protein",TRUE
+"214602_at",0.533107177200708,0.0420732961979159,2.15747032572434,-3.89593677106923,1.06033014955004,"COL4A4","collagen type IV alpha 4 chain",TRUE
+"229779_at",0.641880516735663,0.112233664068695,1.65396679170968,-4.68846327319996,1.12245446282882,"COL4A4","collagen type IV alpha 4 chain",TRUE
+"241565_at",0.896229101808264,0.579954815575353,0.561705428047893,-5.78716621456442,0.266814558293238,"COL4A4","collagen type IV alpha 4 chain",TRUE
+"213110_s_at",0.657015752622694,0.125045274016639,1.59425580967562,-4.77220143702502,1.14419736840026,"COL4A5","collagen type IV alpha 5 chain",TRUE
+"234387_at",0.67818193964437,0.145508669209318,1.50868141241664,-4.88799616191086,1.27656596425742,"COL4A5","collagen type IV alpha 5 chain",TRUE
+"213992_at",0.0881213647048109,0.000332016481558135,4.23921706544433,0.315938881667972,2.50187629248817,"COL4A6","collagen type IV alpha 6 chain",TRUE
+"211473_s_at",0.137844713664596,0.000902248416910106,3.83038176266791,-0.565859156688531,3.23191742884284,"COL4A6","collagen type IV alpha 6 chain",TRUE
+"210945_at",0.366569797255916,0.0108395064380305,2.78145436740109,-2.74353659372282,0.943236740223572,"COL4A6","collagen type IV alpha 6 chain",TRUE
+"212488_at",0.970740500720217,0.860600236397017,0.177665109578561,-5.92432106997635,0.207546481599646,"COL5A1","collagen type V alpha 1 chain",TRUE
+"212489_at",0.981927697474733,0.913305004616005,0.110120703959933,-5.93377880135937,0.214014474274792,"COL5A1","collagen type V alpha 1 chain",TRUE
+"203325_s_at",0.990797621966014,0.953371308616956,0.0591393083248085,-5.93798014157585,0.103567615939639,"COL5A1","collagen type V alpha 1 chain",TRUE
+"221730_at",0.57656767976275,0.0612685545390321,1.9716042969113,-4.20529911142354,2.9491303966124,"COL5A2","collagen type V alpha 2 chain",TRUE
+"221729_at",0.597654932724127,0.0748200590724316,1.86954988708689,-4.36713681078611,2.43639570782968,"COL5A2","collagen type V alpha 2 chain",TRUE
+"218975_at",0.913040340235698,0.63487823786156,0.481506266170772,-5.82738530398937,0.217707792770708,"COL5A3","collagen type V alpha 3 chain",TRUE
+"52255_s_at",0.928176113526188,0.684374948317193,0.411893656224646,-5.85738624751353,0.258252794255462,"COL5A3","collagen type V alpha 3 chain",TRUE
+"212091_s_at",0.0681210092794308,0.000180407548219945,4.48803525084639,0.85329563822668,5.01852888623181,"COL6A1","collagen type VI alpha 1 chain",TRUE
+"213428_s_at",0.112181752094536,0.000566294715648687,4.02118954440254,-0.154979600048588,4.07337623851389,"COL6A1","collagen type VI alpha 1 chain",TRUE
+"212940_at",0.131554208455398,0.000812933954669614,3.87315565943908,-0.473916024685898,3.16425525482462,"COL6A1","collagen type VI alpha 1 chain",TRUE
+"212937_s_at",0.179861672609328,0.0016347339898548,3.58539068713829,-1.08971425570445,3.7361926278119,"COL6A1","collagen type VI alpha 1 chain",TRUE
+"212938_at",0.360736459722853,0.0103548026391026,2.8015820104124,-2.70398975237573,2.00255133676964,"COL6A1","collagen type VI alpha 1 chain",TRUE
+"214200_s_at",0.835952408568777,0.416343746234849,0.828282554930432,-5.61094560926584,0.731702700536022,"COL6A1","collagen type VI alpha 1 chain",TRUE
+"216904_at",0.840621400595373,0.429850786695314,0.804156361242007,-5.62953032527806,0.497319993778056,"COL6A1","collagen type VI alpha 1 chain",TRUE
+"212939_at",0.844245372791972,0.440972261720048,-0.784642583433534,-5.64418436686353,-0.324721241028662,"COL6A1","collagen type VI alpha 1 chain",TRUE
+"209156_s_at",0.0823353801878483,0.000300841250557794,4.27944021530987,0.402862093012966,5.9403898335516,"COL6A2","collagen type VI alpha 2 chain",TRUE
+"213290_at",0.197114136379983,0.00215636046182455,3.47039958980339,-1.33343987998661,1.49125716932081,"COL6A2","collagen type VI alpha 2 chain",TRUE
+"201438_at",0.504797365607203,0.0327852847786224,2.27708199766574,-3.68766401861307,2.60112485603889,"COL6A3","collagen type VI alpha 3 chain",TRUE
+"1553834_at",0.789614764278615,0.316966074553975,-1.0238266784333,-5.44163642773456,-0.729261205319651,"COL6A5","collagen type VI alpha 5 chain",TRUE
+"1553835_a_at",0.955752634534966,0.798260244975923,-0.258692909845977,-5.90714069467786,-0.260062858632762,"COL6A5","collagen type VI alpha 5 chain",TRUE
+"242641_at",0.80008362094922,0.335603434162769,-0.984282752116263,-5.47851556392476,-0.648679024128959,"COL6A6","collagen type VI alpha 6 chain",TRUE
+"230867_at",0.97304633500821,0.86908166806124,-0.166746798517499,-5.92615000337961,-0.152604562661541,"COL6A6","collagen type VI alpha 6 chain",TRUE
+"204136_at",0.0723378272955723,0.000222934287929622,4.40168449772425,0.666940909153884,1.89253314541575,"COL7A1","collagen type VII alpha 1 chain",TRUE
+"217312_s_at",0.0992303055764299,0.000446468315899438,4.11833358567423,0.054744187721071,2.6189906748288,"COL7A1","collagen type VII alpha 1 chain",TRUE
+"221152_at",0.771008055264122,0.279607640050791,-1.10832554883731,-5.35846275128346,-1.12079335676089,"COL8A1","collagen type VIII alpha 1 chain",TRUE
+"214587_at",0.89732810490777,0.583613640477839,0.556251410624166,-5.79009190993154,0.788727983092145,"COL8A1","collagen type VIII alpha 1 chain",TRUE
+"226237_at",0.959515701539076,0.817049337294097,-0.234109908454557,-5.91302399395363,-0.46161840045477,"COL8A1","collagen type VIII alpha 1 chain",TRUE
+"221900_at",0.100788021093145,0.000462693978863819,4.10375519779823,0.0232567746586492,2.93628700298756,"COL8A2","collagen type VIII alpha 2 chain",TRUE
+"52651_at",0.245492559900582,0.00333839787473172,3.28746563042206,-1.71731048266474,1.46945540641591,"COL8A2","collagen type VIII alpha 2 chain",TRUE
+"1555527_at",0.398439157867667,0.0138606543806914,2.67245006784987,-2.95548520582387,1.60953836475234,"COL9A1","collagen type IX alpha 1 chain",TRUE
+"222008_at",0.990918916504081,0.957122902945946,-0.0543760311658058,-5.93824345809988,-0.016994088520141,"COL9A1","collagen type IX alpha 1 chain",TRUE
+"232542_at",0.94282868233554,0.743777023481895,0.330969717771338,-5.88647050319404,0.205076664259275,"COL9A2","collagen type IX alpha 2 chain",TRUE
+"213622_at",0.986998758050399,0.940045236885532,0.0760711110270562,-5.93686533004333,0.0412010950348023,"COL9A2","collagen type IX alpha 2 chain",TRUE
+"204724_s_at",0.837015771520825,0.41915851530389,0.823214809388087,-5.61489206428677,1.3400248099334,"COL9A3","collagen type IX alpha 3 chain",TRUE
+"230956_at",0.83364851657447,0.411196082070661,0.837606715759816,-5.60362533607853,0.677078501201348,"COLCA1","colorectal cancer associated 1",TRUE
+"238701_x_at",0.953931868692178,0.78744217858994,0.272920151688655,-5.90346936132241,0.0697917446195113,"COLCA1","colorectal cancer associated 1",TRUE
+"228338_at",0.863739823286196,0.489337360618725,-0.703065127580969,-5.7017537449861,-0.461851627551017,"COLCA2","colorectal cancer associated 2",TRUE
+"207420_at",0.631569426994436,0.102830014432638,1.7015637208339,-4.62003383585025,1.09668826245667,"COLEC10","collectin subfamily member 10",TRUE
+"219873_at",0.996666735634539,0.983384521783722,-0.0210622573096526,-5.93946741275457,-0.0105654866198659,"COLEC11","collectin subfamily member 11",TRUE
+"221019_s_at",0.805670827550507,0.345061002082583,-0.964793993326332,-5.49620467856004,-0.71076764916142,"COLEC12","collectin subfamily member 12",TRUE
+"218473_s_at",0.768285407497397,0.271434667340719,1.1278843180619,-5.33837469038599,0.424778571451776,"COLGALT1","collagen beta(1-O)galactosyltransferase 1",TRUE
+"222644_s_at",0.769258076576208,0.275735166664622,1.11754005835205,-5.3490376520904,0.506948367028187,"COLGALT1","collagen beta(1-O)galactosyltransferase 1",TRUE
+"237382_at",0.73957587762701,0.227915673684573,1.24008825371187,-5.21720133036841,0.914848144185318,"COLGALT2","collagen beta(1-O)galactosyltransferase 2",TRUE
+"209883_at",0.789406360796076,0.316043828514584,1.02582508762248,-5.43973779859199,0.377416331605625,"COLGALT2","collagen beta(1-O)galactosyltransferase 2",TRUE
+"206073_at",0.87579870142401,0.523383958084298,0.648409466610097,-5.73695405628778,0.507502128934457,"COLQ","collagen like tail subunit of asymmetric acetylcholinesterase",TRUE
+"226024_at",0.635916735157933,0.107213177223335,-1.67893892027704,-4.65274451661121,-0.42718063371999,"COMMD1","copper metabolism domain containing 1",TRUE
+"222637_at",0.113570520993144,0.000600308743795495,-3.9973346168542,-0.206437713315849,-1.49921698377456,"COMMD10","COMM domain containing 10",TRUE
+"235481_at",0.434309499513877,0.0196820197411346,-2.51425939743522,-3.25581484120086,-2.4610756415039,"COMMD10","COMM domain containing 10",TRUE
+"218439_s_at",0.547195868806649,0.0476598660293043,-2.09662084849592,-3.9992023966611,-0.774343979712386,"COMMD10","COMM domain containing 10",TRUE
+"242980_at",0.855405088766616,0.46834436234171,0.7378575207108,-5.67793292360755,0.432504608837704,"COMMD10","COMM domain containing 10",TRUE
+"223491_at",0.630161231812663,0.101324503378253,1.70952391533216,-4.60844679232298,0.652691995240769,"COMMD2","COMM domain containing 2",TRUE
+"226910_at",0.760905446901853,0.259995163402294,1.15599847915797,-5.30895682425187,0.510499888422231,"COMMD2","COMM domain containing 2",TRUE
+"218048_at",0.534211007350826,0.0423472618872221,-2.15432090571826,-3.90132720970335,-0.997657762751967,"COMMD3","COMM domain containing 3",TRUE
+"202265_at",0.57323405915128,0.0601804023690599,-1.98063875613816,-4.19068867719364,-0.93831734425699,"COMMD3-BMI1///BMI1","COMMD3-BMI1 readthrough///BMI1 proto-oncogene, polycomb ring finger",TRUE
+"209133_s_at",0.820536502908875,0.379792341924591,0.896176517267228,-5.55589969890596,0.213952802371591,"COMMD4","COMM domain containing 4",TRUE
+"206441_s_at",0.959869386255065,0.818515949736398,-0.232197433078726,-5.91345722217787,-0.0922568996861273,"COMMD4","COMM domain containing 4",TRUE
+"209132_s_at",0.972819824894874,0.868292451081617,-0.167761876910489,-5.92598484257206,-0.0698193414412724,"COMMD4","COMM domain containing 4",TRUE
+"232640_at",0.673356287352323,0.139118435465643,-1.5342760791642,-4.85389265348527,-0.563542612764113,"COMMD5","COMM domain containing 5",TRUE
+"224387_at",0.857235095927283,0.472133890144641,-0.731510454174391,-5.68236000474793,-0.29020139451281,"COMMD5","COMM domain containing 5",TRUE
+"225312_at",0.250356179889913,0.00352124192657235,3.26500478261383,-1.76406119145822,0.935441413619841,"COMMD6","COMM domain containing 6",TRUE
+"240030_at",0.883016663633454,0.540610210941857,0.621504477859799,-5.75327783450669,0.399241668694538,"COMMD6","COMM domain containing 6",TRUE
+"244178_at",0.80792868298796,0.349311863505302,-0.956153157484451,-5.5039441902674,-0.992329729671925,"COMMD7","COMM domain containing 7",TRUE
+"224815_at",0.989480295962421,0.948163725030876,-0.0657535567284543,-5.93757786797269,-0.0246747462078467,"COMMD7","COMM domain containing 7",TRUE
+"218351_at",0.722362743674536,0.198918947759741,1.3242501717643,-5.11984205701629,0.395181896477121,"COMMD8","COMM domain containing 8",TRUE
+"218072_at",0.952644489493803,0.783072130254707,-0.278683553678027,-5.90192659034149,-0.126234579016359,"COMMD9","COMM domain containing 9",TRUE
+"205713_s_at",0.660054711393139,0.127913629549234,1.58159236376896,-4.7896533525105,1.07124721148761,"COMP","cartilage oligomeric matrix protein",TRUE
+"216204_at",0.689243424115541,0.1583589555325,-1.45987463380142,-4.95175033304105,-0.894358123655306,"COMT","catechol-O-methyltransferase",TRUE
+"208817_at",0.826587298950731,0.394815699237383,-0.867781701865859,-5.5794116283105,-0.525394696497941,"COMT","catechol-O-methyltransferase",TRUE
+"208818_s_at",0.90344422113846,0.604356768359145,-0.525644444374021,-5.80599562403506,-0.295295670593381,"COMT","catechol-O-methyltransferase",TRUE
+"213981_at",0.976330538523238,0.88561706553379,-0.145518714916503,-5.92937483984926,-0.0452740111141408,"COMT","catechol-O-methyltransferase",TRUE
+"226870_at",0.828070400350931,0.397882715822941,-0.862071511239707,-5.58405494772064,-0.369505564636638,"COMTD1","catechol-O-methyltransferase domain containing 1",TRUE
+"214337_at",0.818982634279384,0.372949787440111,-0.909353487339771,-5.54475077220209,-0.318353586317497,"COPA","coatomer protein complex subunit alpha",TRUE
+"208684_at",0.967558480465905,0.84771184495725,-0.194299470296949,-5.92131244540169,-0.0557726146097988,"COPA","coatomer protein complex subunit alpha",TRUE
+"214336_s_at",0.973493137611142,0.871962359261081,-0.163043212168223,-5.92674412631559,-0.0704458771622996,"COPA","coatomer protein complex subunit alpha",TRUE
+"1559862_at",0.997608949249317,0.987957242724388,-0.0152651849869085,-5.93956998307543,-0.013892556178499,"COPA","coatomer protein complex subunit alpha",TRUE
+"233308_at",0.774230543658252,0.288582849257041,1.08731963578003,-5.37968941323443,0.851513834532595,"COPB1","coatomer protein complex subunit beta 1",TRUE
+"201359_at",0.904432955312383,0.608252458970001,0.519953386854332,-5.80885620595934,0.166524816382996,"COPB1","coatomer protein complex subunit beta 1",TRUE
+"201358_s_at",0.927034337839692,0.681283963315982,0.416177272405666,-5.85567273271293,0.114080845136051,"COPB1","coatomer protein complex subunit beta 1",TRUE
+"226256_at",0.55937703282623,0.0535573827199114,-2.03897732435786,-4.09526910699909,-1.05900584639311,"COPB2","coatomer protein complex subunit beta 2",TRUE
+"201098_at",0.834303441371375,0.412448385209042,-0.835331601100012,-5.6054185635583,-0.232865150201873,"COPB2","coatomer protein complex subunit beta 2",TRUE
+"201264_at",0.847717593536494,0.446766256819727,-0.774595977061676,-5.65159670067252,-0.28377550088903,"COPE","coatomer protein complex subunit epsilon",TRUE
+"220469_at",0.910327933615304,0.627243152572785,0.492453605648713,-5.82225084192557,0.285054047002429,"COPE","coatomer protein complex subunit epsilon",TRUE
+"217749_at",0.837609393049242,0.421999274743693,-0.81812191621794,-5.6188352471958,-0.319328652374681,"COPG1","coatomer protein complex subunit gamma 1",TRUE
+"223457_at",0.635916735157933,0.107077790050358,1.67962591794476,-4.65175613298116,0.694046364472944,"COPG2","coatomer protein complex subunit gamma 2",TRUE
+"233569_at",0.897375964261386,0.583810820605356,0.555957969823995,-5.79024853488416,0.44999823670569,"COPG2","coatomer protein complex subunit gamma 2",TRUE
+"213486_at",0.980019293742949,0.906110667565463,-0.119302683642944,-5.93275342462244,-0.0451617986413666,"COPG2IT1","COPG2 imprinted transcript 1 (non-protein coding)",TRUE
+"225096_at",0.851733415458562,0.456316559022652,-0.758207308278965,-5.66349457761871,-0.238269262896585,"COPRS","coordinator of PRMT5 and differentiation stimulator",TRUE
+"209838_at",0.271305453183858,0.00427240960569368,-3.18325736514173,-1.93341426448548,-1.14384808849177,"COPS2","COP9 signalosome subunit 2",TRUE
+"202467_s_at",0.55937703282623,0.0529783463474181,-2.04437845990911,-4.08634209317051,-0.585893903281109,"COPS2","COP9 signalosome subunit 2",TRUE
+"202078_at",0.727421292706596,0.207802344230166,1.29751195838383,-5.15136199064825,0.490952795616728,"COPS3","COP9 signalosome subunit 3",TRUE
+"218042_at",0.57258310251954,0.0600387549473164,-1.98182541362459,-4.1887662724156,-0.545053904103378,"COPS4","COP9 signalosome subunit 4",TRUE
+"237649_at",0.663129351367592,0.13106454049216,1.56795057268645,-4.80833167742558,1.1850755355373,"COPS4","COP9 signalosome subunit 4",TRUE
+"201652_at",0.768462369991551,0.271591299593112,-1.12750546601529,-5.33876674715651,-0.418515655394732,"COPS5","COP9 signalosome subunit 5",TRUE
+"201405_s_at",0.771153198056133,0.280042266528394,-1.10729716475092,-5.35951034426131,-0.303679671543893,"COPS6","COP9 signalosome subunit 6",TRUE
+"213504_at",0.865702540607078,0.495718612552837,-0.692661264624717,-5.70866392013038,-0.179620825583491,"COPS6","COP9 signalosome subunit 6",TRUE
+"209029_at",0.762177151731041,0.261517025449919,1.15220637859734,-5.31296195202313,0.377152381282608,"COPS7A","COP9 signalosome subunit 7A",TRUE
+"243628_at",0.716472449896956,0.192485581949372,1.34420207388505,-5.09596937669163,0.518886033986266,"COPS7B","COP9 signalosome subunit 7B",TRUE
+"225696_at",0.857316604145187,0.472462372410662,0.730961697692256,-5.68274105720986,0.26523580068448,"COPS7B","COP9 signalosome subunit 7B",TRUE
+"219997_s_at",0.916042382946954,0.645778465629764,-0.465979691960232,-5.83447384284396,-0.132092447065654,"COPS7B","COP9 signalosome subunit 7B",TRUE
+"202141_s_at",0.509649162655312,0.033920682266167,-2.26091286234911,-3.71621331195598,-0.679239789207783,"COPS8","COP9 signalosome subunit 8",TRUE
+"202143_s_at",0.616413638398853,0.0872954707330763,-1.7890051698578,-4.49055774093836,-0.520707554317497,"COPS8","COP9 signalosome subunit 8",TRUE
+"214260_at",0.636497183477553,0.107753414362473,-1.67620487418218,-4.65667495433985,-0.578175094760736,"COPS8","COP9 signalosome subunit 8",TRUE
+"202142_at",0.820293495506061,0.379317596244613,-0.89708567946564,-5.55513529628885,-0.295301654890112,"COPS8","COP9 signalosome subunit 8",TRUE
+"236204_at",0.898237062260476,0.587308216529488,-0.550761351975476,-5.7930089536175,-0.321690851722174,"COPS8","COP9 signalosome subunit 8",TRUE
+"243152_at",0.989234433802225,0.947475804205233,0.0666275159801124,-5.93752152877854,0.0389972516727926,"COPS8","COP9 signalosome subunit 8",TRUE
+"226845_s_at",0.505687926665686,0.0330373529775918,-2.27344859306462,-3.69408987533503,-0.808843324618296,"COPS9","COP9 signalosome subunit 9",TRUE
+"1553515_at",0.644953768720197,0.115396208585487,-1.63871559363701,-4.71007667421903,-0.788860222210176,"COPS9","COP9 signalosome subunit 9",TRUE
+"222386_s_at",0.655235030401569,0.123973478628113,-1.59904977863257,-4.76556641924527,-0.513725775100045,"COPZ1","coatomer protein complex subunit zeta 1",TRUE
+"217726_at",0.667291317524503,0.133843231583125,-1.55614400243702,-4.8243945802442,-0.509278209121412,"COPZ1","coatomer protein complex subunit zeta 1",TRUE
+"235897_at",0.731054546207485,0.213871167795414,-1.2797509515834,-5.17199761759076,-1.01402209057325,"COPZ2","coatomer protein complex subunit zeta 2",TRUE
+"219561_at",0.930827859648584,0.69362103555603,0.399126325868084,-5.86238988571141,0.360311521815036,"COPZ2","coatomer protein complex subunit zeta 2",TRUE
+"225747_at",0.975657122206595,0.883924088693858,0.14768884097369,-5.92906524362319,0.0536738204583163,"COQ10A","coenzyme Q10A",TRUE
+"219397_at",0.862634144901168,0.485657144329513,-0.709100769588445,-5.69769990062038,-0.207701382551114,"COQ10B","coenzyme Q10B",TRUE
+"1561948_at",0.974292018919448,0.87451632072942,0.159761641718626,-5.92725942849515,0.126065283490809,"COQ10B","coenzyme Q10B",TRUE
+"232126_at",0.953983577550391,0.788170705775969,-0.271960262659198,-5.90372319908074,-0.0954324898061403,"COQ2","coenzyme Q2, polyprenyltransferase",TRUE
+"213379_at",0.990810941805126,0.955049214125569,0.0570087597512565,-5.93810065018398,0.0251823931837123,"COQ2","coenzyme Q2, polyprenyltransferase",TRUE
+"221227_x_at",0.56861088242915,0.0584942216636293,1.99492843236009,-4.16748761386938,0.50888503100459,"COQ3","coenzyme Q3, methyltransferase",TRUE
+"223515_s_at",0.843475287501313,0.438491125065559,0.78896948968856,-5.64096427020074,0.307219309283887,"COQ3","coenzyme Q3, methyltransferase",TRUE
+"228931_at",0.434309499513877,0.0197136306069193,-2.51352725266781,-3.2571833415766,-1.08337038300721,"COQ4","coenzyme Q4",TRUE
+"218328_at",0.644809676493259,0.115015761399045,-1.64053153931374,-4.70751123302435,-0.638519754015162,"COQ4","coenzyme Q4",TRUE
+"223114_at",0.812731301505073,0.361422018560482,-0.931920348552122,-5.52530873435682,-0.445025585383954,"COQ5","coenzyme Q5, methyltransferase",TRUE
+"218760_at",0.78725170044443,0.313100836326733,-1.03222974732316,-5.43363040993737,-0.321637140801986,"COQ6","coenzyme Q6, monooxygenase",TRUE
+"209745_at",0.649647727520048,0.120198196828401,-1.61621625133636,-4.74168067669131,-0.436635557247783,"COQ7","coenzyme Q7, hydroxylase",TRUE
+"209746_s_at",0.937623890519979,0.723666353733942,-0.358088104701152,-5.87742104646081,-0.110404360094238,"COQ7","coenzyme Q7, hydroxylase",TRUE
+"210820_x_at",0.943512938262733,0.747493347703875,-0.325986610132996,-5.88805674162236,-0.104742084750235,"COQ7","coenzyme Q7, hydroxylase",TRUE
+"222542_x_at",0.673190784310977,0.13881430534683,1.53551809627512,-4.85222612856158,0.634876013955967,"COQ8A","coenzyme Q8A",TRUE
+"218168_s_at",0.909955315434437,0.625141783508931,0.495477272495827,-5.82081282375479,0.176015017015393,"COQ8A","coenzyme Q8A",TRUE
+"227324_at",0.486821797225537,0.0286926812640173,-2.33996445731993,-3.57550833494817,-0.637728217113659,"COQ8B","coenzyme Q8B",TRUE
+"220434_at",0.870808709484996,0.510413557707142,0.668988896622419,-5.72402002703097,0.41055868345132,"COQ8B","coenzyme Q8B",TRUE
+"212228_s_at",0.660460734341314,0.128601096987611,-1.57859239262527,-4.79377177858839,-0.562323869329852,"COQ9","coenzyme Q9",TRUE
+"235822_at",0.673366993714442,0.139320452208423,-1.53345231049281,-4.85499738694783,-0.809319843742812,"COQ9","coenzyme Q9",TRUE
+"239260_at",0.75147824277753,0.244733819678037,1.19496901992813,-5.26713024465126,0.928118629909435,"CORIN","corin, serine peptidase",TRUE
+"239261_s_at",0.820536502908875,0.380469448202302,0.894881115328933,-5.55698760420489,0.554143987418809,"CORIN","corin, serine peptidase",TRUE
+"220356_at",0.831025767174474,0.405053484901184,0.848830514175685,-5.59471218649401,0.757093477886979,"CORIN","corin, serine peptidase",TRUE
+"209083_at",0.830378107406877,0.402773249354008,0.853024607368931,-5.59135313212997,0.935270940559829,"CORO1A","coronin 1A",TRUE
+"64486_at",0.82376894572504,0.390979499617097,-0.87496447907867,-5.57353039922116,-0.440634872941041,"CORO1B","coronin 1B",TRUE
+"221754_s_at",0.867852903118377,0.501045171281842,-0.684035346139149,-5.71431860599976,-0.415761225475034,"CORO1B","coronin 1B",TRUE
+"221676_s_at",0.634202341398092,0.105058721521494,1.68995962405019,-4.63685216059132,0.873509582174471,"CORO1C","coronin 1C",TRUE
+"222409_at",0.646482265190661,0.117472360396328,1.62889340611159,-4.72391492656404,0.981310540724607,"CORO1C","coronin 1C",TRUE
+"205538_at",0.675622576285316,0.141888533399965,1.52306504363376,-4.86888699507302,1.00377212886077,"CORO2A","coronin 2A",TRUE
+"227177_at",0.737123149977386,0.222804014883632,1.25430150975921,-5.20114267331321,1.11466023467855,"CORO2A","coronin 2A",TRUE
+"209789_at",0.912241810302154,0.632073276331248,0.48552107396171,-5.8255154010641,0.421180045755093,"CORO2B","coronin 2B",TRUE
+"1552301_a_at",0.0941413026938497,0.000387056935036087,4.17662842132997,0.180686552420139,2.01029007508167,"CORO6","coronin 6",TRUE
+"219040_at",0.904832003218088,0.61009080644009,-0.517273857170002,-5.81019255392613,-0.352553965000166,"CORO7","coronin 7",TRUE
+"210182_at",0.710842845257879,0.184478632047635,1.36977981100322,-5.06492848859084,0.417229088256238,"CORT","cortistatin",TRUE
+"221059_s_at",0.537586664847644,0.0436453315806683,2.1396444221874,-3.92638183018182,2.03736881638092,"COTL1","coactosin like F-actin binding protein 1",TRUE
+"1556346_at",0.54402892121853,0.046412272568073,2.10963032870694,-3.97728230541933,1.75270762469413,"COTL1","coactosin like F-actin binding protein 1",TRUE
+"224583_at",0.572728296251991,0.0600958799377718,1.98134654842911,-4.18954213552587,1.90588936401963,"COTL1","coactosin like F-actin binding protein 1",TRUE
+"1553538_s_at",0.982884736081404,0.916779742815108,0.105689489807479,-5.93424431903764,0.0223814421048107,"COX1","cytochrome c oxidase subunit I",TRUE
+"1569685_at",0.685154158710982,0.153771077630697,1.4769172325101,-4.92968045780588,0.553561209365379,"COX10","COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor",TRUE
+"203858_s_at",0.81129279516104,0.355440468500915,0.943820023559848,-5.51488039708483,0.291055834648418,"COX10","COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor",TRUE
+"1557192_at",0.709914655587487,0.182877636235952,1.37499889121505,-5.05853476955284,0.441300853342787,"COX10-AS1","COX10 antisense RNA 1",TRUE
+"230451_at",0.989768753740502,0.950650849537233,-0.0625942574026581,-5.93777532757413,-0.0613304510895283,"COX10-AS1///LOC100506974","COX10 antisense RNA 1///uncharacterized LOC100506974",TRUE
+"214277_at",0.421623075967463,0.0175666642350961,-2.56593587390376,-3.15870825973418,-1.07202597739536,"COX11","COX11, cytochrome c oxidase copper chaperone",TRUE
+"211727_s_at",0.695744345349551,0.165216930343098,-1.43512907763365,-4.9834245665455,-0.67449873996592,"COX11","COX11, cytochrome c oxidase copper chaperone",TRUE
+"239760_at",0.813021058415276,0.362115638849529,-0.930549040301281,-5.52650267433775,-0.504328439567471,"COX11","COX11, cytochrome c oxidase copper chaperone",TRUE
+"203551_s_at",0.854400503339099,0.465702919217276,-0.742299651628972,-5.67481295396345,-0.390064419025229,"COX11","COX11, cytochrome c oxidase copper chaperone",TRUE
+"225772_s_at",0.554642754132296,0.0510520052348458,-2.06273458369845,-4.05588736484745,-0.85038700049995,"COX14","COX14, cytochrome c oxidase assembly factor",TRUE
+"219547_at",0.828426831961877,0.398301619298946,0.861293799658743,-5.58468514775567,0.292594204746861,"COX15","COX15, cytochrome c oxidase assembly homolog",TRUE
+"223281_s_at",0.859064198633089,0.475721757489615,0.725528741136698,-5.6864990036344,0.303874204863444,"COX15","COX15, cytochrome c oxidase assembly homolog",TRUE
+"221550_at",0.870808709484996,0.510307476653459,0.669158400226756,-5.72391188729571,0.260850275116503,"COX15","COX15, cytochrome c oxidase assembly homolog",TRUE
+"235855_at",0.955730092376044,0.797673392691428,0.259463276284777,-5.90694690070556,0.269807118471466,"COX15","COX15, cytochrome c oxidase assembly homolog",TRUE
+"223191_at",0.42796179417767,0.0184504513209663,-2.543674136972,-3.20066430703752,-0.724771339025454,"COX16","COX16, cytochrome c oxidase assembly homolog",TRUE
+"1558346_at",0.774230543658252,0.288827424261828,-1.08675387009024,-5.38025612263952,-0.489746597324078,"COX17","COX17, cytochrome c oxidase copper chaperone",TRUE
+"227442_at",0.580630437263151,0.0629841910130095,-1.95764435831033,-4.22778578494137,-0.798961324140098,"COX18","COX18, cytochrome c oxidase assembly factor",TRUE
+"230909_at",0.790263177427656,0.319834359215714,-1.01763732971232,-5.44749551574021,-0.708582574945651,"COX18","COX18, cytochrome c oxidase assembly factor",TRUE
+"235533_at",0.852546356114556,0.458575986998895,0.754360361635042,-5.66625252741863,0.304727532133906,"COX19","COX19, cytochrome c oxidase assembly factor",TRUE
+"231831_at",0.881466832418197,0.53813812390134,0.625336797552192,-5.75099334639008,0.521729413224739,"COX19","COX19, cytochrome c oxidase assembly factor",TRUE
+"1553570_x_at",0.932091525948902,0.699877227250123,-0.390525816608838,-5.86567304892448,-0.0867520180705412,"COX2","cytochrome c oxidase subunit II",TRUE
+"1553569_at",0.937462538530338,0.722673764788833,-0.35943351188839,-5.87695375581266,-0.0809643023030944,"COX2","cytochrome c oxidase subunit II",TRUE
+"224824_at",0.705559553212919,0.177550894973785,1.39262848599933,-5.0367881973869,0.442505700844096,"COX20","COX20, cytochrome c oxidase assembly factor",TRUE
+"224820_at",0.961212424803935,0.82384065965646,-0.225261345384787,-5.91499877221692,-0.0822121989010789,"COX20","COX20, cytochrome c oxidase assembly factor",TRUE
+"206848_at",0.973071267819624,0.870645755051982,-0.164735623275442,-5.92647428397739,-0.0751292747781029,"COX20","COX20, cytochrome c oxidase assembly factor",TRUE
+"213758_at",0.56861088242915,0.0582472588387849,-1.99705192932668,-4.16403028532822,-1.11117994913466,"COX4I1","cytochrome c oxidase subunit 4I1",TRUE
+"202698_x_at",0.657015752622694,0.125520907413635,-1.59213933809732,-4.77512577046517,-0.426715910414961,"COX4I1","cytochrome c oxidase subunit 4I1",TRUE
+"200086_s_at",0.680482416269178,0.148193948431954,-1.4982002127869,-4.90182943165297,-0.440054199804294,"COX4I1","cytochrome c oxidase subunit 4I1",TRUE
+"227323_at",0.874406257596174,0.520453641352579,-0.653033968961063,-5.73408135514464,-0.320920496803874,"COX4I1","cytochrome c oxidase subunit 4I1",TRUE
+"232761_at",0.621578279007659,0.0919265105451474,1.76162844204233,-4.53160958086223,0.468064456582722,"COX4I2","cytochrome c oxidase subunit 4I2",TRUE
+"203663_s_at",0.743323328391634,0.233496563117558,-1.22484476983502,-5.23424873870478,-0.360999089009978,"COX5A","cytochrome c oxidase subunit 5A",TRUE
+"229426_at",0.993474831312851,0.969456314608665,-0.0387251742512971,-5.93895308822079,-0.0135446380821023,"COX5A","cytochrome c oxidase subunit 5A",TRUE
+"213735_s_at",0.63671491109964,0.107801919196147,-1.67595996748666,-4.65702679294007,-0.474009344000178,"COX5B","cytochrome c oxidase subunit 5B",TRUE
+"202343_x_at",0.769847953580141,0.277660959494272,-1.11294596329261,-5.35374538886731,-0.331514287044808,"COX5B","cytochrome c oxidase subunit 5B",TRUE
+"211025_x_at",0.769847953580141,0.277996694107138,-1.11214742506908,-5.35456192649141,-0.354157617269468,"COX5B","cytochrome c oxidase subunit 5B",TRUE
+"213736_at",0.835952408568777,0.416012025084235,-0.828881210364995,-5.61047791547237,-0.541671634840253,"COX5B","cytochrome c oxidase subunit 5B",TRUE
+"224344_at",0.6936485676385,0.162660508487726,1.44425479820746,-4.97179502565125,0.696192932578499,"COX6A1","cytochrome c oxidase subunit 6A1",TRUE
+"200925_at",0.767965891104819,0.271053239859635,-1.12880756027762,-5.33741878159775,-0.341647203267415,"COX6A1","cytochrome c oxidase subunit 6A1",TRUE
+"234876_at",0.895690630367785,0.575287667286333,-0.56868760466626,-5.78338036490307,-0.340075434574296,"COX6A1P1","cytochrome c oxidase subunit 6A1 pseudogene 1",TRUE
+"206353_at",0.695744345349551,0.165368909706563,1.43459014151356,-4.9841094872903,0.500632118583564,"COX6A2","cytochrome c oxidase subunit 6A2",TRUE
+"201441_at",0.482262518773694,0.0274756651577369,-2.36025785432057,-3.53893979467317,-0.658993256298078,"COX6B1","cytochrome c oxidase subunit 6B1",TRUE
+"1553367_a_at",0.0672685243895878,0.000160525542480113,4.53569085273451,0.956041546432581,2.07920497351007,"COX6B2","cytochrome c oxidase subunit 6B2",TRUE
+"201754_at",0.724697226571437,0.202285935329931,-1.31400851387506,-5.13197948868298,-0.393907041626125,"COX6C","cytochrome c oxidase subunit 6C",TRUE
+"204570_at",0.894563570028521,0.571233912747854,-0.57477537791668,-5.78004248830431,-0.257312870096423,"COX7A1","cytochrome c oxidase subunit 7A1",TRUE
+"201597_at",0.952613441433926,0.782852035284274,0.278974077608809,-5.90184797449784,0.0759240395765755,"COX7A2","cytochrome c oxidase subunit 7A2",TRUE
+"201256_at",0.762782461459876,0.262411616373482,1.14998488499881,-5.31530286924613,0.335444941973705,"COX7A2L","cytochrome c oxidase subunit 7A2 like",TRUE
+"239252_at",0.180622515496298,0.00166476390058132,-3.57785117515393,-1.10574339748053,-2.63428133520845,"COX7B","cytochrome c oxidase subunit 7B",TRUE
+"202110_at",0.605913415325856,0.0793649343968812,-1.83894331252877,-4.41449452623062,-0.526521576824166,"COX7B","cytochrome c oxidase subunit 7B",TRUE
+"231265_at",0.697699759202153,0.168470566088962,1.42367730583668,-4.99793303451435,1.65961603942618,"COX7B2","cytochrome c oxidase subunit 7B2",TRUE
+"217491_x_at",0.768852835478002,0.272543636099281,-1.12520545029462,-5.34114443003476,-0.290867832707036,"COX7C","cytochrome c oxidase subunit 7C",TRUE
+"213846_at",0.820536502908875,0.379889239195386,-0.89599104584305,-5.55605555094465,-0.262976214840139,"COX7C","cytochrome c oxidase subunit 7C",TRUE
+"201134_x_at",0.857253318078192,0.472175284388198,-0.731441289329103,-5.68240804726314,-0.206595162007021,"COX7C","cytochrome c oxidase subunit 7C",TRUE
+"201119_s_at",0.677509122383198,0.144985805326443,-1.51074062843522,-4.88526930219715,-0.435815232678152,"COX8A","cytochrome c oxidase subunit 8A",TRUE
+"231487_at",0.851861294910063,0.45697992273909,-0.757076668771849,-5.66430653197327,-0.646523037189311,"COX8C","cytochrome c oxidase subunit 8C",TRUE
+"204846_at",0.905768970192239,0.612096056893696,-0.514355419929961,-5.81164039537808,-0.81507690401426,"CP","ceruloplasmin (ferroxidase)",TRUE
+"228143_at",0.931398124704888,0.69682378218662,0.394719661247822,-5.86408088917522,0.451172074397235,"CP","ceruloplasmin (ferroxidase)",TRUE
+"227253_at",0.968066640321622,0.849915917194222,-0.191450945212074,-5.9218466819154,-0.218584424698948,"CP","ceruloplasmin (ferroxidase)",TRUE
+"1558034_s_at",0.98193446371783,0.913329257473621,-0.110089767401452,-5.9337821175655,-0.172286026080115,"CP","ceruloplasmin (ferroxidase)",TRUE
+"205615_at",0.886560514511744,0.549431972501099,0.607904206369277,-5.761275832432,0.361367454297175,"CPA1","carboxypeptidase A1",TRUE
+"206212_at",0.94895689004559,0.768809033950882,0.297562739265411,-5.89664894573961,0.0898555926698359,"CPA2","carboxypeptidase A2",TRUE
+"205624_at",0.997466539876354,0.987158805307005,-0.0162773605784959,-5.93955443299487,-0.0122532152097188,"CPA3","carboxypeptidase A3",TRUE
+"205832_at",0.64513208805899,0.116267835123161,1.63457404311821,-4.71591940561588,1.3911344940944,"CPA4","carboxypeptidase A4",TRUE
+"240744_at",0.9832781796011,0.9184809088943,-0.103520847049594,-5.93446518428688,-0.0479774265309221,"CPA5","carboxypeptidase A5",TRUE
+"1552511_a_at",0.556381379241158,0.0519123221668802,2.05446144661362,-4.06963542105202,2.10400428619948,"CPA6","carboxypeptidase A6",TRUE
+"224028_at",0.96741016687371,0.847357528881243,0.194757538400238,-5.92122580168632,0.143406991187652,"CPA6","carboxypeptidase A6",TRUE
+"227721_at",0.888750194607196,0.555349854974287,-0.59884527162907,-5.76650842118335,-0.4965769175196,"CPAMD8","C3 and PZP like, alpha-2-macroglobulin domain containing 8",TRUE
+"205509_at",0.928244741861625,0.68454972540654,0.41165167758336,-5.85748252245091,0.328157070997404,"CPB1","carboxypeptidase B1",TRUE
+"206651_s_at",0.79943091106207,0.334063888320455,0.987490769857218,-5.47557289749778,0.673155365861748,"CPB2","carboxypeptidase B2",TRUE
+"201943_s_at",0.792436690618566,0.323935289290238,1.00885512370814,-5.45575393853189,0.54446941709586,"CPD","carboxypeptidase D",TRUE
+"201940_at",0.819018525257656,0.374896888012941,0.90558775335837,-5.54795227169652,0.44525925993832,"CPD","carboxypeptidase D",TRUE
+"201942_s_at",0.895457620469779,0.574263758950596,0.570223214000544,-5.78254165075947,0.323261427190983,"CPD","carboxypeptidase D",TRUE
+"201941_at",0.911274533678096,0.629288844553449,0.489514517424212,-5.82364039370206,0.240309622451145,"CPD","carboxypeptidase D",TRUE
+"229600_s_at",0.967057781266004,0.84602300491112,-0.1964832258298,-5.92089756199995,-0.160995574392646,"CPD","carboxypeptidase D",TRUE
+"201117_s_at",0.449589282893031,0.0214627831916351,-2.47462867282927,-3.32959127939857,-4.02866800198759,"CPE","carboxypeptidase E",TRUE
+"201116_s_at",0.746259710622309,0.237807716901897,-1.21325738090372,-5.24708546324118,-1.96531983640899,"CPE","carboxypeptidase E",TRUE
+"222903_s_at",0.380731642340006,0.0118925950267094,2.74051521705177,-2.82358706928387,0.813541328642766,"CPEB1","cytoplasmic polyadenylation element binding protein 1",TRUE
+"219578_s_at",0.860696412805564,0.480258366015037,-0.7180029997566,-5.69166048761487,-0.404956735450559,"CPEB1","cytoplasmic polyadenylation element binding protein 1",TRUE
+"1560030_at",0.969829083058377,0.855524096268976,-0.18421022518341,-5.92316927146831,-0.0812126514740683,"CPEB1-AS1","CPEB1 antisense RNA 1",TRUE
+"226939_at",0.793202774551725,0.325028165725777,-1.00652779877574,-5.45793159155612,-0.708216436873485,"CPEB2","cytoplasmic polyadenylation element binding protein 2",TRUE
+"235462_at",0.975398143273847,0.882293575765844,-0.149779584880258,-5.92876264698639,-0.0559172034469109,"CPEB2","cytoplasmic polyadenylation element binding protein 2",TRUE
+"235479_at",0.991689960875868,0.960775630094434,0.0497395217970982,-5.93847854864917,0.0151339418685055,"CPEB2","cytoplasmic polyadenylation element binding protein 2",TRUE
+"1561471_at",0.997763494670794,0.98907569299728,-0.0138473577503228,-5.93959008715822,-0.00964204960488502,"CPEB2-AS1","CPEB2 antisense RNA 1 (head to head)",TRUE
+"239765_at",0.733934891101761,0.218039404410899,-1.26777615739875,-5.18577366768363,-1.06454078987183,"CPEB3","cytoplasmic polyadenylation element binding protein 3",TRUE
+"243651_at",0.839519981963042,0.427937914798533,0.807544058527147,-5.6269518414399,0.694175848004042,"CPEB3","cytoplasmic polyadenylation element binding protein 3",TRUE
+"205773_at",0.978375993063006,0.895990202993283,-0.13223721388592,-5.93116995068616,-0.0950656129500187,"CPEB3","cytoplasmic polyadenylation element binding protein 3",TRUE
+"1555250_a_at",0.99514093116831,0.977797655664963,0.0281460379996685,-5.93929763696883,0.0283234499506912,"CPEB3","cytoplasmic polyadenylation element binding protein 3",TRUE
+"224831_at",0.827564951695026,0.396370050258543,-0.864884238206614,-5.58177130366063,-0.448479120287988,"CPEB4","cytoplasmic polyadenylation element binding protein 4",TRUE
+"224828_at",0.88698237223329,0.551061127471463,-0.605405251311672,-5.76272684426637,-0.355337424816806,"CPEB4","cytoplasmic polyadenylation element binding protein 4",TRUE
+"242280_x_at",0.983364220761052,0.918881491841807,-0.103010259159591,-5.93451651981871,-0.0811794427975769,"CPEB4","cytoplasmic polyadenylation element binding protein 4",TRUE
+"224829_at",0.988788646552704,0.946074202965976,0.0684083256948479,-5.93740442891323,0.0378834489189916,"CPEB4","cytoplasmic polyadenylation element binding protein 4",TRUE
+"228728_at",0.972112264314695,0.866092032313251,0.170592977346132,-5.92551891956806,0.226804683399719,"CPED1","cadherin like and PC-esterase domain containing 1",TRUE
+"220032_at",0.998038817582822,0.990696535111757,0.0117927136650249,-5.93961574603412,0.00562871260695452,"CPED1","cadherin like and PC-esterase domain containing 1",TRUE
+"223500_at",0.726636642789909,0.206406338353196,-1.30165419656048,-5.14651460363785,-1.10183749931725,"CPLX1","complexin 1",TRUE
+"225815_at",0.674325549770726,0.140721285666622,1.52776696257138,-4.86260899880315,1.04315198155781,"CPLX2","complexin 2",TRUE
+"206368_at",0.865885012497452,0.496393229661091,0.691565871180786,-5.7093857520836,0.441496532895126,"CPLX2","complexin 2",TRUE
+"222927_s_at",0.632024529529662,0.102927232024364,-1.70105310874291,-4.6207757089014,-1.24572176638478,"CPLX3","complexin 3",TRUE
+"219775_s_at",0.826134344333512,0.393871292141022,-0.869545771481003,-5.57797138847181,-0.561377340665519,"CPLX3","complexin 3",TRUE
+"243403_x_at",0.627053909308516,0.097858377084762,1.72824062660436,-4.58104306362114,0.764735131573724,"CPM","carboxypeptidase M",TRUE
+"217557_s_at",0.822092613794682,0.385913653875708,0.884520080730745,-5.56563656971422,0.61450397958833,"CPM","carboxypeptidase M",TRUE
+"206100_at",0.868397087637799,0.503200767563443,0.680559325561625,-5.71657815326689,0.927039474617612,"CPM","carboxypeptidase M",TRUE
+"235706_at",0.883114005048829,0.540867957440605,0.621105450006981,-5.75351492183287,0.610982269325428,"CPM","carboxypeptidase M",TRUE
+"235019_at",0.923708852928185,0.6722521277088,0.42873983620958,-5.85054701082678,0.401946750643108,"CPM","carboxypeptidase M",TRUE
+"241765_at",0.954577684533304,0.792624075590276,-0.266098248922612,-5.90525410570829,-0.21308165496886,"CPM","carboxypeptidase M",TRUE
+"206256_at",0.966064677476069,0.841843080446492,0.20189231005141,-5.91985001941095,0.0735084142333564,"CPN1","carboxypeptidase N subunit 1",TRUE
+"216223_at",0.990448946049971,0.95189978542456,-0.0610080300739292,-5.93787080423803,-0.0347534731522527,"CPN2","carboxypeptidase N subunit 2",TRUE
+"206918_s_at",0.907283646004164,0.616421867363816,0.508074978147475,-5.81472904443907,0.325020852134907,"CPNE1","copine 1",TRUE
+"225129_at",0.635916735157933,0.107002061531235,1.68001050932401,-4.65120268768254,1.11305316278088,"CPNE2","copine 2",TRUE
+"202119_s_at",0.718706241731185,0.194537240928744,-1.3377832140045,-5.1036823355459,-0.58898948847728,"CPNE3","copine 3",TRUE
+"202118_s_at",0.778397054392363,0.298072765052362,-1.06561485188202,-5.4012415212367,-0.546909884612656,"CPNE3","copine 3",TRUE
+"231336_at",0.790419670473584,0.320143458667353,1.01697265845476,-5.4481228104627,0.913798164551732,"CPNE4","copine 4",TRUE
+"228796_at",0.992376456171815,0.964545800594577,-0.0449551086880656,-5.93869919270784,-0.036773506757025,"CPNE4","copine 4",TRUE
+"227189_at",0.660054711393139,0.127885342236292,1.58171609062753,-4.78948336626515,1.2333937866769,"CPNE5","copine 5",TRUE
+"215700_x_at",0.877667349610475,0.528269863892659,0.64073017649222,-5.74168104844701,0.189349579256929,"CPNE6","copine 6",TRUE
+"210408_s_at",0.959357995170594,0.815970026729206,-0.235517908844398,-5.91270278398939,-0.0887884671925936,"CPNE6","copine 6",TRUE
+"219707_at",0.80056683899707,0.336432491225626,0.982559404928796,-5.48009276548631,0.35129605132901,"CPNE7","copine 7",TRUE
+"243727_at",0.734551465704364,0.218840582073313,-1.26549468311632,-5.18838577190952,-1.21029354433939,"CPNE8","copine 8",TRUE
+"228365_at",0.778580821633075,0.298611202804404,1.06439828821554,-5.40243802135589,1.8159412207712,"CPNE8","copine 8",TRUE
+"241706_at",0.899755026004388,0.591413344672617,0.544681221769122,-5.79620672523931,0.749282497106432,"CPNE8","copine 8",TRUE
+"239139_at",0.403630903577261,0.0150083516593063,2.63685819683817,-3.02383714926304,1.91759272542539,"CPNE9","copine family member 9",TRUE
+"1553506_at",0.639795984318275,0.110277775147973,1.66358109689236,-4.67475970526213,0.818624500504504,"CPO","carboxypeptidase O",TRUE
+"204172_at",0.528176582660474,0.0408161354242543,2.17216434429318,-3.87072216304537,1.21613473767457,"CPOX","coproporphyrinogen oxidase",TRUE
+"218610_s_at",0.732148799347852,0.21587509454571,1.27397172831636,-5.17865995749014,1.30457769286192,"CPPED1","calcineurin like phosphoesterase domain containing 1",TRUE
+"222686_s_at",0.837015771520825,0.419154431392016,0.823222146575022,-5.61488636692002,0.663043277613554,"CPPED1","calcineurin like phosphoesterase domain containing 1",TRUE
+"239135_at",0.899998627338565,0.594324155940597,0.540382563104932,-5.79844673664433,0.429489588720975,"CPPED1","calcineurin like phosphoesterase domain containing 1",TRUE
+"203501_at",0.884332704164424,0.543425883758872,-0.617150907075684,-5.75585662964885,-0.69787634886387,"CPQ","carboxypeptidase Q",TRUE
+"208454_s_at",0.885029460971826,0.545438061151077,-0.614047046225874,-5.75768450159498,-0.916095444405308,"CPQ","carboxypeptidase Q",TRUE
+"217564_s_at",0.641326159307468,0.111839261222693,-1.65589407070294,-4.6857211170969,-1.19139833083571,"CPS1","carbamoyl-phosphate synthase 1",TRUE
+"204920_at",0.867692227847244,0.500564834310015,-0.684811069027643,-5.71381285451215,-0.476729424831268,"CPS1","carbamoyl-phosphate synthase 1",TRUE
+"220479_at",0.983364220761052,0.918884029349955,-0.103007024910448,-5.93451684418845,-0.072394971697594,"CPS1-IT1","CPS1 intronic transcript 1",TRUE
+"201638_s_at",0.661974206478491,0.129398437693397,1.57512959059648,-4.79851797826629,1.00263039026975,"CPSF1","cleavage and polyadenylation specific factor 1",TRUE
+"225994_at",0.51470556386048,0.03505760264803,-2.2452099086206,-3.7438236148105,-0.708811942985276,"CPSF2","cleavage and polyadenylation specific factor 2",TRUE
+"233208_x_at",0.77547560202111,0.292715827353616,-1.07780493440723,-5.38918497772683,-0.370707937301038,"CPSF2","cleavage and polyadenylation specific factor 2",TRUE
+"225986_x_at",0.861357981297227,0.481840582679025,-0.715388033610775,-5.69344196105841,-0.203369748809219,"CPSF2","cleavage and polyadenylation specific factor 2",TRUE
+"225082_at",0.939976205834042,0.730386666553473,0.348996588574259,-5.88053335812875,0.108781803682012,"CPSF3","cleavage and polyadenylation specific factor 3",TRUE
+"232437_at",0.726636642789909,0.20612290033552,-1.30249786859034,-5.14552570461317,-1.01673988559585,"CPSF3L","cleavage and polyadenylation specific factor 3-like",TRUE
+"224312_x_at",0.850964124514683,0.453992471738827,0.762176307866605,-5.66063521978365,0.241272230800195,"CPSF3L","cleavage and polyadenylation specific factor 3-like",TRUE
+"206688_s_at",0.919354071504066,0.656762608272866,-0.45045031839051,-5.84133601634443,-0.119840997572823,"CPSF4","cleavage and polyadenylation specific factor 4",TRUE
+"226934_at",0.7717895132349,0.281823931251403,-1.1030935780436,-5.36378346949195,-0.537921341290929,"CPSF6","cleavage and polyadenylation specific factor 6",TRUE
+"202470_s_at",0.84196911130542,0.434990425003095,-0.795100105384013,-5.63637330878198,-0.277214281129414,"CPSF6","cleavage and polyadenylation specific factor 6",TRUE
+"202469_s_at",0.981204545941987,0.911304377557094,-0.112673054005937,-5.93350199963776,-0.0247279102158284,"CPSF6","cleavage and polyadenylation specific factor 6",TRUE
+"217866_at",0.908667507590078,0.620019887840776,-0.502866917165618,-5.81726223499012,-0.15656772432752,"CPSF7","cleavage and polyadenylation specific factor 7",TRUE
+"235326_at",0.976371465776674,0.887118457184886,0.143594769319209,-5.92964549054257,0.151426709562978,"CPSF7","cleavage and polyadenylation specific factor 7",TRUE
+"203634_s_at",0.91671872326659,0.647932367397978,0.462925445713844,-5.83584146353453,0.252830215310501,"CPT1A","carnitine palmitoyltransferase 1A",TRUE
+"203633_at",0.953931868692178,0.787491423095958,-0.272855260125998,-5.90348654955054,-0.175765716154102,"CPT1A","carnitine palmitoyltransferase 1A",TRUE
+"210687_at",0.986356978750617,0.935555309758175,0.0817807933152936,-5.93642647966668,0.0770625431203165,"CPT1A","carnitine palmitoyltransferase 1A",TRUE
+"210688_s_at",0.990918916504081,0.957061068298888,-0.0544545298449737,-5.9382392976864,-0.0346735492613384,"CPT1A","carnitine palmitoyltransferase 1A",TRUE
+"227468_at",0.919540842310091,0.658285287770632,-0.448306492449389,-5.84226542734448,-0.481918808145942,"CPT1C","carnitine palmitoyltransferase 1C",TRUE
+"204263_s_at",0.774230543658252,0.286997579477702,-1.09099518191299,-5.37600133555196,-0.417865182807482,"CPT2","carnitine palmitoyltransferase 2",TRUE
+"204264_at",0.812302873476553,0.358829536548676,-0.93706144457603,-5.52081821798728,-0.327255267622709,"CPT2","carnitine palmitoyltransferase 2",TRUE
+"220734_s_at",0.972309558036541,0.866672867709286,-0.169845525847878,-5.92564268541005,-0.0716278820698406,"CPTP","ceramide-1-phosphate transfer protein",TRUE
+"208146_s_at",0.606900628956089,0.0807305874313245,-1.83004451120161,-4.42815902291568,-2.17840539808273,"CPVL","carboxypeptidase, vitellogenic like",TRUE
+"1560493_a_at",0.934081042629428,0.70813569743343,0.379218352502843,-5.86988230409065,0.17090952718021,"CPXCR1","CPX chromosome region, candidate 1",TRUE
+"1560494_a_at",0.947062793209778,0.759634478130414,0.309764706844768,-5.89305550244872,0.343789243624473,"CPXCR1","CPX chromosome region, candidate 1",TRUE
+"227860_at",0.77547560202111,0.292625226868125,1.07801247136812,-5.38897865306944,0.501962716399404,"CPXM1","carboxypeptidase X, M14 family member 1",TRUE
+"236144_at",0.821745015752602,0.384728466634387,-0.886767462829078,-5.56376847223742,-0.663326071054185,"CPXM2","carboxypeptidase X, M14 family member 2",TRUE
+"226824_at",0.87927534655779,0.533258184115405,0.632929712333967,-5.74642720221931,0.176861796345847,"CPXM2","carboxypeptidase X, M14 family member 2",TRUE
+"1570026_at",0.987487323337591,0.94104159389637,0.0748044369490496,-5.93695838722187,0.0335183109538875,"CPXM2","carboxypeptidase X, M14 family member 2",TRUE
+"217552_x_at",0.64513208805899,0.116270387686567,-1.6345619529084,-4.71593644536544,-1.33181106717079,"CR1","complement component 3b/4b receptor 1 (Knops blood group)",TRUE
+"206244_at",0.877857073443889,0.528940194102791,-0.63967963124341,-5.74232350425215,-0.409752707798229,"CR1","complement component 3b/4b receptor 1 (Knops blood group)",TRUE
+"217484_at",0.936992192746977,0.71841878217125,-0.365208642846992,-5.87492826544982,-0.10930283507456,"CR1","complement component 3b/4b receptor 1 (Knops blood group)",TRUE
+"208488_s_at",0.994701128358967,0.975565571680806,-0.0309765663701177,-5.93921613126713,-0.016034766342969,"CR1","complement component 3b/4b receptor 1 (Knops blood group)",TRUE
+"244313_at",0.997763494670794,0.988999432096735,-0.0139440305422655,-5.93958877859196,-0.010576261371237,"CR1","complement component 3b/4b receptor 1 (Knops blood group)",TRUE
+"239206_at",0.69410086222651,0.163501074469636,-1.4412415434772,-4.97564167852217,-0.621247306674049,"CR1L","complement component 3b/4b receptor 1-like",TRUE
+"239205_s_at",0.986342822130003,0.934770057574834,0.0827796516344393,-5.93634644596568,0.0539831464176528,"CR1L///CR1","complement component 3b/4b receptor 1-like///complement component 3b/4b receptor 1 (Knops blood group)",TRUE
+"205544_s_at",0.812896635201594,0.361646346651328,0.93147665240034,-5.52569521867763,0.558340607083659,"CR2","complement component 3d receptor 2",TRUE
+"244097_at",0.931038852978249,0.694791872885153,-0.397514440591084,-5.86301057161164,-0.377834845249372,"CR2","complement component 3d receptor 2",TRUE
+"1563897_at",0.557512088623721,0.0523403014130655,2.05039138387829,-4.07638566433208,0.744193395303243,"CRABP1","cellular retinoic acid binding protein 1",TRUE
+"205350_at",0.815100643136321,0.366008886870413,-0.922884399340774,-5.53314616477878,-1.5888091182332,"CRABP1","cellular retinoic acid binding protein 1",TRUE
+"202575_at",0.613271734293818,0.0846746835333156,-1.80505759815022,-4.46627251626901,-2.14932774973682,"CRABP2","cellular retinoic acid binding protein 2",TRUE
+"1560874_at",0.662015916975184,0.12998760611526,1.57258222667454,-4.80200424267709,0.49023787141334,"CRACR2A","calcium release activated channel regulator 2A",TRUE
+"228752_at",0.768852835478002,0.273398828159814,-1.12314505433233,-5.34327075607349,-0.931462769941036,"CRACR2A","calcium release activated channel regulator 2A",TRUE
+"223955_at",0.91876780831279,0.654729635552047,-0.453315949525807,-5.8400868920978,-0.237401615792511,"CRACR2A","calcium release activated channel regulator 2A",TRUE
+"227429_at",0.921079309141156,0.664028105515723,-0.44024007296928,-5.84572347897989,-0.492180769359601,"CRACR2B","calcium release activated channel regulator 2B",TRUE
+"209833_at",0.438309018314998,0.0200849652509176,-2.50500770785043,-3.2730925705375,-0.809998134549835,"CRADD","CASP2 and RIPK1 domain containing adaptor with death domain",TRUE
+"240930_at",0.754194966982681,0.247480784684706,1.18782325887871,-5.27489032788594,0.922159263102452,"CRAMP1","cramped chromatin regulator homolog 1",TRUE
+"225172_at",0.849646596450765,0.451071567031639,-0.767181943958205,-5.65700892634549,-0.227612563972594,"CRAMP1","cramped chromatin regulator homolog 1",TRUE
+"242355_at",0.997491609704468,0.987347758200149,-0.0160378242955754,-5.93955820313717,-0.0112873202351267,"CRAMP1","cramped chromatin regulator homolog 1",TRUE
+"209522_s_at",0.915409740314202,0.643403202523225,-0.469353055625991,-5.83295309430758,-0.53085215073418,"CRAT","carnitine O-acetyltransferase",TRUE
+"205843_x_at",0.93032716386748,0.692003346444248,-0.401355162365067,-5.86152755703006,-0.495034558369958,"CRAT","carnitine O-acetyltransferase",TRUE
+"1570391_at",0.970643058558138,0.860201897748075,0.178178431872107,-5.92423223739812,0.140220828976472,"CRAT37","cervical cancer-associated transcript 37",TRUE
+"244403_at",0.932249295738588,0.701015547127414,0.3889641840496,-5.86626162846932,0.250842849243889,"CRB1","crumbs 1, cell polarity complex component",TRUE
+"220522_at",0.969946179106301,0.857934470375122,0.181101308166756,-5.92372155212887,0.118905511902919,"CRB1","crumbs 1, cell polarity complex component",TRUE
+"1552506_at",0.92070400963176,0.662596626950175,-0.442247946186825,-5.84486846821212,-0.39549868196681,"CRB2","crumbs 2, cell polarity complex component",TRUE
+"232609_at",0.73217873363841,0.215897312185065,1.27390788574495,-5.17873341208341,0.895867528427816,"CRB3","crumbs 3, cell polarity complex component",TRUE
+"222533_at",0.615637099066718,0.085841155795882,-1.79786069096877,-4.47717996871347,-0.568524651153323,"CRBN","cereblon",TRUE
+"218142_s_at",0.65284137151906,0.121823661359481,-1.60877071898044,-4.75206480708177,-0.575802824464883,"CRBN","cereblon",TRUE
+"203899_s_at",0.830056770608453,0.401797576422923,-0.854823831197047,-5.58990740205906,-0.326739102101904,"CRCP","CGRP receptor component",TRUE
+"203898_at",0.837140519794197,0.419619077923727,-0.822387647210775,-5.61553405545552,-0.255184764865236,"CRCP","CGRP receptor component",TRUE
+"220620_at",0.921729477898827,0.666125574968884,0.43730135797404,-5.84696798426059,0.396678884676915,"CRCT1","cysteine rich C-terminal 1",TRUE
+"225565_at",0.710383535193614,0.183345724554616,1.3734692425748,-5.06041078542873,0.409114934244588,"CREB1","cAMP responsive element binding protein 1",TRUE
+"204312_x_at",0.948429371744093,0.765394599718688,0.302098379089261,-5.89532992576322,0.0865686591899753,"CREB1","cAMP responsive element binding protein 1",TRUE
+"214513_s_at",0.962955596345424,0.831919663344784,-0.214758872216203,-5.91724439446067,-0.0655283722304585,"CREB1","cAMP responsive element binding protein 1",TRUE
+"204314_s_at",0.986280972175967,0.932856286659842,-0.0852143745644818,-5.93614729567643,-0.0236843599089447,"CREB1","cAMP responsive element binding protein 1",TRUE
+"204313_s_at",0.990848691272535,0.956851189453823,-0.0547209722811701,-5.93822513154808,-0.0182131878204448,"CREB1","cAMP responsive element binding protein 1",TRUE
+"225572_at",0.99388023907845,0.971048714976346,0.0367052565955528,-5.93902729365552,0.0103463971628237,"CREB1","cAMP responsive element binding protein 1",TRUE
+"237289_at",0.997039490727282,0.98483619601672,-0.0192218251435342,-5.93950352296648,-0.00561736041614758,"CREB1","cAMP responsive element binding protein 1",TRUE
+"209432_s_at",0.886404465314046,0.54927084197238,-0.608151575869993,-5.76113188423488,-0.303359923533424,"CREB3","cAMP responsive element binding protein 3",TRUE
+"213059_at",0.929799592139474,0.690254536511929,-0.403766985576474,-5.86058910551536,-0.535771471235268,"CREB3L1","cAMP responsive element binding protein 3 like 1",TRUE
+"213498_at",0.987257510450304,0.940535719996414,0.075447541379571,-5.93691133622531,0.0686802955201236,"CREB3L1","cAMP responsive element binding protein 3 like 1",TRUE
+"237819_at",0.723009970036937,0.1997898209333,1.32158827251333,-5.12300432975935,0.552429004793931,"CREB3L2","cAMP responsive element binding protein 3 like 2",TRUE
+"228759_at",0.886685015168353,0.54971817741018,0.607464915447594,-5.76153132343338,0.375954494168171,"CREB3L2","cAMP responsive element binding protein 3 like 2",TRUE
+"212345_s_at",0.998870448604467,0.995440675860766,-0.00577911725253017,-5.93966721373219,-0.00253423883612314,"CREB3L2","cAMP responsive element binding protein 3 like 2",TRUE
+"234361_at",0.92775708065487,0.682951385133922,0.413865510980141,-5.85659964009944,0.288257172717359,"CREB3L3","cAMP responsive element binding protein 3 like 3",TRUE
+"226455_at",0.664123571602771,0.132187808864152,-1.56315312486936,-4.81487015016756,-1.48568906046468,"CREB3L4","cAMP responsive element binding protein 3 like 4",TRUE
+"232555_at",0.992451894371035,0.964841047055857,0.0445804825872483,-5.93871552838127,0.0267795992587061,"CREB5","cAMP responsive element binding protein 5",TRUE
+"228177_at",0.580630437263151,0.0633613201893342,-1.95462080658347,-4.23264178298171,-0.967576802845053,"CREBBP","CREB binding protein",TRUE
+"202160_at",0.774360462422895,0.290430407698753,-1.08305426476849,-5.3839554145874,-0.331484246871707,"CREBBP","CREB binding protein",TRUE
+"235858_at",0.852994610926182,0.459138325692576,0.753404680128856,-5.66693561504575,0.57952636436107,"CREBBP","CREB binding protein",TRUE
+"211808_s_at",0.936143408699214,0.714986530956476,0.369876339658711,-5.87326789240421,0.240196523253458,"CREBBP","CREB binding protein",TRUE
+"201988_s_at",0.797490281058829,0.330863062240881,0.994193246230418,-5.46939671835542,0.406477167438336,"CREBL2","cAMP responsive element binding protein like 2",TRUE
+"201989_s_at",0.859483694145165,0.477043137048474,0.72333240106287,-5.68801063761501,0.327582124925138,"CREBL2","cAMP responsive element binding protein like 2",TRUE
+"201990_s_at",0.921294973929502,0.664392702755413,0.439728962170142,-5.84594051508611,0.205676367823987,"CREBL2","cAMP responsive element binding protein like 2",TRUE
+"238476_at",0.697172073261335,0.167150333136093,-1.42830251002239,-4.99208473247702,-0.607788836279714,"CREBRF","CREB3 regulatory factor",TRUE
+"1554229_at",0.819203514175924,0.376064350447616,0.903336050288557,-5.54986073120229,0.248733177462158,"CREBRF","CREB3 regulatory factor",TRUE
+"235556_at",0.913667834629936,0.638105281487775,0.476897226850124,-5.82951324886492,0.21193957391004,"CREBRF","CREB3 regulatory factor",TRUE
+"225956_at",0.923708852928185,0.672278395023443,-0.428703199573187,-5.85056217691569,-0.201949870266468,"CREBRF","CREB3 regulatory factor",TRUE
+"225957_at",0.955337239053323,0.795529019787083,-0.262279583099746,-5.90623355639425,-0.109008923517339,"CREBRF","CREB3 regulatory factor",TRUE
+"202979_s_at",0.39657361496013,0.0137181402787034,-2.67706201547664,-2.9465965889838,-0.927002153355064,"CREBZF","CREB/ATF bZIP transcription factor",TRUE
+"202978_s_at",0.531571149526209,0.0417647014212395,-2.1610401077326,-3.88982091011368,-0.835770106742318,"CREBZF","CREB/ATF bZIP transcription factor",TRUE
+"202977_s_at",0.725836505745628,0.204891739692486,-1.30617298771817,-5.14121163055883,-0.761412208808308,"CREBZF","CREB/ATF bZIP transcription factor",TRUE
+"225595_at",0.743553048228796,0.234134739451343,-1.22311934693149,-5.23616688065296,-0.821986104331307,"CREBZF","CREB/ATF bZIP transcription factor",TRUE
+"213584_s_at",0.789267479986321,0.315562635802487,-1.02686940566103,-5.4387442932247,-0.443712381545762,"CREBZF","CREB/ATF bZIP transcription factor",TRUE
+"213580_at",0.966089564318167,0.842018480268967,-0.201665208928282,-5.91989457051307,-0.166505419086308,"CREBZF","CREB/ATF bZIP transcription factor",TRUE
+"225594_at",0.986421906591669,0.936037308886274,0.0811677219446081,-5.93647512125695,0.0273343273786875,"CREBZF","CREB/ATF bZIP transcription factor",TRUE
+"201200_at",0.669423128374382,0.135514956917452,1.54913820181565,-4.83388076648967,0.742056284782056,"CREG1","cellular repressor of E1A stimulated genes 1",TRUE
+"231489_x_at",0.123760100530367,0.000719749946013552,3.9230563959243,-0.366520238528356,3.57281009708041,"CREG2","cellular repressor of E1A stimulated genes 2",TRUE
+"1552714_at",0.556381379241158,0.0517992635933634,2.05554163428965,-4.06784244670173,1.47556442155596,"CREG2","cellular repressor of E1A stimulated genes 2",TRUE
+"203368_at",0.751464513744428,0.244697551062351,1.1950637677256,-5.26702707918431,0.586135374142293,"CRELD1","cysteine rich with EGF like domains 1",TRUE
+"218358_at",0.968917934155285,0.853174129517459,-0.187243017893819,-5.92262148593267,-0.108036667447447,"CRELD2","cysteine rich with EGF like domains 2",TRUE
+"207630_s_at",0.703077519740086,0.174936745835284,1.40143466558503,-5.02583970505743,0.414881780553905,"CREM","cAMP responsive element modulator",TRUE
+"214508_x_at",0.704989495199878,0.176792153062378,-1.39517373278219,-5.03362961864521,-0.593570010829667,"CREM","cAMP responsive element modulator",TRUE
+"210171_s_at",0.788758616802423,0.314978357928691,-1.02813895020033,-5.43753529116951,-0.869293038849956,"CREM","cAMP responsive element modulator",TRUE
+"209967_s_at",0.866047073324492,0.496660374651842,0.691132335481463,-5.7096711380248,0.313514904249681,"CREM","cAMP responsive element modulator",TRUE
+"230511_at",0.950725225726738,0.77515188134333,0.289153880499738,-5.89904199797359,0.115779311520032,"CREM","cAMP responsive element modulator",TRUE
+"228092_at",0.972112264314695,0.866054192141769,-0.17064167564377,-5.9255108371151,-0.0552403703210231,"CREM","cAMP responsive element modulator",TRUE
+"205629_s_at",0.560319585017338,0.054294890926783,2.03217291897495,-4.106493285485,1.20148442955048,"CRH","corticotropin releasing hormone",TRUE
+"205630_at",0.79220528400952,0.322981510537126,-1.01089070566023,-5.45384553117765,-0.78949313957062,"CRH","corticotropin releasing hormone",TRUE
+"205984_at",0.89547555116602,0.574613798125927,-0.569698086146551,-5.78282871001385,-0.43982160102987,"CRHBP","corticotropin releasing hormone binding protein",TRUE
+"211897_s_at",0.497885178357455,0.0309779875732205,2.30390824712174,-3.64003432986481,1.42318016638628,"CRHR1","corticotropin releasing hormone receptor 1",TRUE
+"208593_x_at",0.87360589195992,0.519018567691524,-0.655303970260014,-5.73266408128594,-0.212307543660383,"CRHR1","corticotropin releasing hormone receptor 1",TRUE
+"214619_at",0.97922824128613,0.898926463157538,0.12848222636423,-5.93164639429101,0.0858396361314169,"CRHR1","corticotropin releasing hormone receptor 1",TRUE
+"207897_at",0.61591966964196,0.0869786116224625,-1.79092366532355,-4.48766360333071,-0.911171612997164,"CRHR2","corticotropin releasing hormone receptor 2",TRUE
+"211510_s_at",0.62986301194198,0.101088039190327,1.71078331868335,-4.606609861598,1.34191907533293,"CRHR2","corticotropin releasing hormone receptor 2",TRUE
+"228496_s_at",0.64513208805899,0.115912205152526,1.63626066616773,-4.71354135686915,1.6887117666666,"CRIM1","cysteine rich transmembrane BMP regulator 1",TRUE
+"205081_at",0.895594830714116,0.574856169307466,0.569334576334044,-5.783027271219,1.16625914654996,"CRIP1","cysteine rich protein 1",TRUE
+"208978_at",0.40129202983775,0.0143901376332754,-2.65569806706844,-2.98771058562113,-2.89774165863838,"CRIP2","cysteine rich protein 2",TRUE
+"235720_at",0.327864702134751,0.00771544886914782,2.92998576529457,-2.44891736683936,1.58782257314281,"CRIP3","cysteine rich protein 3",TRUE
+"228318_s_at",0.881970070870254,0.539225202465281,-0.623650409918138,-5.75200028707276,-0.275562967026056,"CRIPAK","cysteine rich PAK1 inhibitor",TRUE
+"241408_at",0.906507435035949,0.614188961403826,-0.511314228696338,-5.81314063858809,-0.231955388035328,"CRIPAK","cysteine rich PAK1 inhibitor",TRUE
+"233068_at",0.118638058428056,0.000659642794003277,3.95876624718939,-0.28958906553713,1.04179513247328,"CRIPT","CXXC repeat containing interactor of PDZ3 domain",TRUE
+"239049_at",0.381135657631489,0.0120039433459794,2.73638933123476,-2.83162529061001,1.07730919370141,"CRIPT","CXXC repeat containing interactor of PDZ3 domain",TRUE
+"239050_s_at",0.485660910112228,0.0282025311313456,2.34804046548943,-3.56097691506309,0.817752839043282,"CRIPT","CXXC repeat containing interactor of PDZ3 domain",TRUE
+"222702_x_at",0.536422380101288,0.0431598676995142,2.14508654895714,-3.91710397504899,0.716707922550404,"CRIPT","CXXC repeat containing interactor of PDZ3 domain",TRUE
+"227942_s_at",0.60427479779745,0.0785423244015597,1.84436795908249,-4.40614150767069,0.610673360214056,"CRIPT","CXXC repeat containing interactor of PDZ3 domain",TRUE
+"218643_s_at",0.671298718565642,0.137332964510861,1.54159987319072,-4.84405023502972,0.583839333921286,"CRIPT","CXXC repeat containing interactor of PDZ3 domain",TRUE
+"216314_at",0.617775129514679,0.0885956998698036,1.78119495212648,-4.50231646849143,1.40124944453442,"CRISP1","cysteine rich secretory protein 1",TRUE
+"207032_s_at",0.950926616697165,0.775932901618183,0.288119946825144,-5.89933154489519,0.174329495773272,"CRISP1","cysteine rich secretory protein 1",TRUE
+"210262_at",0.87887877854929,0.532309912028883,0.634409514130434,-5.74553112127129,0.585220707368978,"CRISP2","cysteine rich secretory protein 2",TRUE
+"207802_at",0.877488742289724,0.527452346950057,-0.642012376590624,-5.7408955523102,-0.94210755417255,"CRISP3","cysteine rich secretory protein 3",TRUE
+"223475_at",0.880685398344064,0.536223206281675,0.628311866485166,-5.74921055190942,0.886279024741,"CRISPLD1","cysteine rich secretory protein LCCL domain containing 1",TRUE
+"221541_at",0.703077519740086,0.174929603717082,1.40145886818736,-5.02580953607339,0.675074202118934,"CRISPLD2","cysteine rich secretory protein LCCL domain containing 2",TRUE
+"1555809_at",0.9116561917482,0.630768707857349,0.487391090597913,-5.82463925691359,0.177567885098297,"CRISPLD2","cysteine rich secretory protein LCCL domain containing 2",TRUE
+"202225_at",0.913157126234238,0.635460490881761,-0.480673880993976,-5.82777108852649,-0.157820214151808,"CRK","CRK proto-oncogene, adaptor protein",TRUE
+"202226_s_at",0.967167123162441,0.846909501508045,0.19533681972088,-5.92111593937229,0.0726191582994336,"CRK","CRK proto-oncogene, adaptor protein",TRUE
+"202224_at",0.99135920925157,0.959388240619594,-0.0515004370594526,-5.93839172820111,-0.0177789402291157,"CRK","CRK proto-oncogene, adaptor protein",TRUE
+"212180_at",0.682825347106105,0.151077277579704,-1.48711718513085,-4.91637276901356,-0.546511330302678,"CRKL","CRK like proto-oncogene, adaptor protein",TRUE
+"206184_at",0.984132887597385,0.922204574952648,-0.0987756853428577,-5.9349325001023,-0.042974721542917,"CRKL","CRK like proto-oncogene, adaptor protein",TRUE
+"206315_at",0.797612393661522,0.33122442665374,0.993434318854,-5.47009795904792,1.2813790257125,"CRLF1","cytokine receptor like factor 1",TRUE
+"208303_s_at",0.909052380289506,0.622212587201397,0.499699936995563,-5.81879019393895,0.345941095090852,"CRLF2","cytokine receptor-like factor 2",TRUE
+"205474_at",0.654191178920817,0.123267447899448,1.60222665349797,-4.76116098262263,0.633632407753652,"CRLF3","cytokine receptor like factor 3",TRUE
+"226937_at",0.818686885011389,0.372300965290247,0.910611212295133,-5.54367876523421,0.68518966056596,"CRLS1","cardiolipin synthase 1",TRUE
+"225324_at",0.820536502908875,0.380674261261639,-0.894489576701648,-5.557316139853,-0.429605587616347,"CRLS1","cardiolipin synthase 1",TRUE
+"237502_at",0.899889458546239,0.593935272082297,0.540956265592418,-5.79814878050817,0.401312368180632,"CRLS1","cardiolipin synthase 1",TRUE
+"241741_at",0.968451827985008,0.85180970717562,-0.189004721301806,-5.92229919234014,-0.093174911507468,"CRLS1","cardiolipin synthase 1",TRUE
+"223978_s_at",0.982021726491165,0.913821694091184,-0.10946164686342,-5.93384924689332,-0.0451397699751279,"CRLS1","cardiolipin synthase 1",TRUE
+"202517_at",0.90344422113846,0.604013054067317,-0.526147404714281,-5.80574135513437,-0.296380644095898,"CRMP1","collapsin response mediator protein 1",TRUE
+"238021_s_at",0.0277242942311338,2.65888916848953e-05,-5.274322610037,2.53023058579613,-2.60335475707537,"CRNDE","colorectal neoplasia differentially expressed (non-protein coding)",TRUE
+"238022_at",0.0592928515268338,0.000125797362178559,-4.63525150484068,1.17039636138503,-2.51657486483553,"CRNDE","colorectal neoplasia differentially expressed (non-protein coding)",TRUE
+"219913_s_at",0.734203380012717,0.218577439587533,-1.266243312731,-5.18752909485877,-0.646922157851384,"CRNKL1","crooked neck pre-mRNA splicing factor 1",TRUE
+"220090_at",0.754682106570676,0.24829863952131,-1.18570722525681,-5.27718049310255,-0.772619545924557,"CRNN","cornulin",TRUE
+"206274_s_at",0.559434208511607,0.0539242688844921,-2.03558198301858,-4.10087297259474,-0.866734487973074,"CROCC","ciliary rootlet coiled-coil, rootletin",TRUE
+"216801_at",0.795635030181504,0.327837097772687,1.00057091645985,-5.46348460749991,0.715431262092166,"CROCC","ciliary rootlet coiled-coil, rootletin",TRUE
+"216419_at",0.807084045192774,0.348427508253026,0.957944896098256,-5.50234458114874,0.698731687426283,"CROCC","ciliary rootlet coiled-coil, rootletin",TRUE
+"211038_s_at",0.796378050779806,0.328703663855408,0.998740347767143,-5.46518505951498,0.394699365292983,"CROCCP2","ciliary rootlet coiled-coil, rootletin pseudogene 2",TRUE
+"1569291_at",0.819018525257656,0.375082218244345,-0.90522999518469,-5.5482557874335,-0.692982532327705,"CROCCP2","ciliary rootlet coiled-coil, rootletin pseudogene 2",TRUE
+"1569293_x_at",0.883515015273005,0.541743792046594,0.619750293014976,-5.75431900993602,0.171755465929207,"CROCCP2","ciliary rootlet coiled-coil, rootletin pseudogene 2",TRUE
+"215827_x_at",0.797127506889432,0.330290905965783,0.995396045809659,-5.46828434804537,0.447108534761016,"CROCCP3","ciliary rootlet coiled-coil, rootletin pseudogene 3",TRUE
+"219139_s_at",0.961212424803935,0.823989439670431,0.225067704972601,-5.91504114149793,0.142679543575184,"CROCCP3","ciliary rootlet coiled-coil, rootletin pseudogene 3",TRUE
+"243283_at",0.536422380101288,0.043270613646772,-2.1438402233318,-3.91923004628072,-1.81367967040612,"CROT","carnitine O-octanoyltransferase",TRUE
+"231102_at",0.623667408398064,0.0949652650910609,-1.74430152347961,-4.5573509093807,-0.932985235030025,"CROT","carnitine O-octanoyltransferase",TRUE
+"204573_at",0.631316839203356,0.102591185466059,-1.70281985680498,-4.61820807243062,-0.859633766060901,"CROT","carnitine O-octanoyltransferase",TRUE
+"205753_at",0.689848451630875,0.158720743637587,1.45854778927728,-4.95345986196982,0.751052877643436,"CRP","C-reactive protein, pentraxin-related",TRUE
+"37020_at",0.783844746433788,0.306593645228883,1.04654301461703,-5.41985772837695,0.514420314787775,"CRP","C-reactive protein, pentraxin-related",TRUE
+"221204_s_at",0.522667179791589,0.0383840455229928,2.20179406590489,-3.81955677683617,1.04992586988917,"CRTAC1","cartilage acidic protein 1",TRUE
+"1555958_at",0.781148062702952,0.30282970895385,-1.05492055851348,-5.41171748333117,-0.42526082522714,"CRTAC1","cartilage acidic protein 1",TRUE
+"206914_at",0.69794616906853,0.168946633851153,1.42201661834952,-5.00002908261335,1.40817761147135,"CRTAM","cytotoxic and regulatory T-cell molecule",TRUE
+"1555889_a_at",0.664941049395485,0.132550388612005,1.56161176305979,-4.81696753795199,0.615686422795234,"CRTAP","cartilage associated protein",TRUE
+"1554464_a_at",0.67842163564685,0.145896325412632,1.5071585952576,-4.89001079678576,0.748962033730072,"CRTAP","cartilage associated protein",TRUE
+"201380_at",0.726636642789909,0.206169926066351,1.30235783111196,-5.14568988527956,0.539462037674729,"CRTAP","cartilage associated protein",TRUE
+"227138_at",0.812302873476553,0.358350666174594,0.938013808830769,-5.51998387947452,0.37428055791603,"CRTAP","cartilage associated protein",TRUE
+"226656_at",0.841372027765592,0.431806322970609,0.800702765708644,-5.6321484840041,0.379625068859841,"CRTAP","cartilage associated protein",TRUE
+"207159_x_at",0.805670827550507,0.345077684956109,0.964759940397023,-5.49623530434767,0.376452943061196,"CRTC1","CREB regulated transcription coactivator 1",TRUE
+"213091_at",0.882092375733396,0.539596919959381,-0.62307418159795,-5.75234375223802,-0.334679395683371,"CRTC1","CREB regulated transcription coactivator 1",TRUE
+"226307_at",0.875279162021058,0.52245401054324,-0.649875525936009,-5.7360454744789,-0.245511068751309,"CRTC2","CREB regulated transcription coactivator 2",TRUE
+"218648_at",0.952743383622821,0.78380242149711,-0.277719749303915,-5.90218681377025,-0.0796276457324776,"CRTC3","CREB regulated transcription coactivator 3",TRUE
+"232879_at",0.954054753819891,0.789026721918026,-0.27083273076129,-5.90402023495946,-0.115837357413648,"CRTC3","CREB regulated transcription coactivator 3",TRUE
+"231742_at",0.826809257703947,0.395053773173441,-0.867337431286531,-5.57977391565842,-0.456305279382852,"CRX","cone-rod homeobox",TRUE
+"217510_at",0.917102138198416,0.649562339720428,0.460617103928213,-5.83686924033075,0.288773157783925,"CRX","cone-rod homeobox",TRUE
+"209674_at",0.907964244160782,0.617714186535299,-0.506202741162544,-5.81564262837844,-0.149894963069187,"CRY1","cryptochrome circadian clock 1",TRUE
+"212695_at",0.819018525257656,0.374793503244614,-0.905787376237931,-5.54778286701318,-0.667122955926033,"CRY2","cryptochrome circadian clock 2",TRUE
+"210199_at",0.90496994347229,0.610612641694307,-0.516513942223408,-5.81057031773536,-0.371959675176921,"CRYAA","crystallin alpha A",TRUE
+"209283_at",0.980287960296053,0.90815813013106,-0.11668851621207,-5.93305370231518,-0.146478459863026,"CRYAB","crystallin alpha B",TRUE
+"206982_at",0.948429371744093,0.76504508036712,0.302563034464219,-5.89519368130211,0.161717938511771,"CRYBA1","crystallin beta A1",TRUE
+"220136_s_at",0.992093589969215,0.963332567520464,0.0464946000899955,-5.93863062792975,0.0158450047676859,"CRYBA2","crystallin beta A2",TRUE
+"206843_at",0.891444650197327,0.56112826212517,-0.590048353027774,-5.7715170223106,-0.40029074858661,"CRYBA4","crystallin beta A4",TRUE
+"206185_at",0.955736115035547,0.7980184043074,0.259010356930304,-5.90706090679862,0.101767693126368,"CRYBB1","crystallin beta B1",TRUE
+"206778_at",0.978197434639598,0.894205013001474,-0.134521123069368,-5.93087346085014,-0.0706309800441245,"CRYBB2","crystallin beta B2",TRUE
+"233556_at",0.550758853959785,0.0491477356830323,2.08149981174888,-4.02457070585068,0.760239176313149,"CRYBB2P1","crystallin beta B2 pseudogene 1",TRUE
+"222048_at",0.841967750949524,0.434681696270803,-0.795642224539816,-5.63596572951173,-0.412050961274791,"CRYBB2P1","crystallin beta B2 pseudogene 1",TRUE
+"1561274_at",0.896421670648767,0.580603935529868,0.560736566613869,-5.78768796326124,0.485970398026484,"CRYBB2P1","crystallin beta B2 pseudogene 1",TRUE
+"206777_s_at",0.915353407558177,0.6428482922377,0.470141938380192,-5.83259590814002,0.350583774570751,"CRYBB2P1///CRYBB2","crystallin beta B2 pseudogene 1///crystallin beta B2",TRUE
+"207685_at",0.993892931327222,0.971310789666262,0.0363728370262977,-5.93903912491831,0.0101482244364659,"CRYBB3","crystallin beta B3",TRUE
+"214030_at",0.66909275739297,0.135201404365387,1.55044676643844,-4.83211147391611,1.42101328613684,"CRYBG3","crystallin beta-gamma domain containing 3",TRUE
+"207587_at",0.946944656062027,0.759253037630492,0.310273042386524,-5.89290269445108,0.198522034708658,"CRYGA","crystallin gamma A",TRUE
+"207715_at",0.976392182310915,0.887438303418168,-0.143184977028317,-5.92970267359243,-0.0804856948852279,"CRYGB","crystallin gamma B",TRUE
+"207531_at",0.913221029035633,0.635894967174246,-0.480052980863989,-5.82805843128403,-0.293888967290389,"CRYGC","crystallin gamma C",TRUE
+"207532_at",0.744931128252932,0.23662677022465,1.21641559452293,-5.24359720450988,0.766286635273318,"CRYGD","crystallin gamma D",TRUE
+"1553082_at",0.774230543658252,0.28942197652589,1.08537995322393,-5.38163123641565,0.865214092603241,"CRYGN","crystallin gamma N",TRUE
+"223643_at",0.943464796017993,0.746444390861589,-0.327392266724179,-5.88761170007174,-0.207915131035637,"CRYGS","crystallin gamma S",TRUE
+"223644_s_at",0.948429371744093,0.765627010854514,-0.301789446415204,-5.89542039493767,-0.204581919122957,"CRYGS","crystallin gamma S",TRUE
+"220753_s_at",0.769258076576208,0.275675803109289,-1.11768204467662,-5.34889187984197,-0.437797368729237,"CRYL1","crystallin lambda 1",TRUE
+"205489_at",0.689985677226298,0.159476199889288,-1.45578504886857,-4.9570153728505,-1.56121032512318,"CRYM","crystallin mu",TRUE
+"202950_at",0.872668627020452,0.516209492838706,0.65975742507512,-5.72986986453924,0.340634165496121,"CRYZ","crystallin zeta",TRUE
+"1560609_at",0.789795896476304,0.317982129687769,1.02162970831555,-5.44371984424188,0.557736965368536,"CRYZL1","crystallin zeta like 1",TRUE
+"219767_s_at",0.888750194607196,0.555487158670539,0.598635692468229,-5.76662857963826,0.206740578760913,"CRYZL1","crystallin zeta like 1",TRUE
+"226151_x_at",0.907224306064369,0.61628464615287,0.508273884251311,-5.81463179213193,0.152176674902581,"CRYZL1","crystallin zeta like 1",TRUE
+"1552347_at",0.976371465776674,0.886034627451446,0.144983577595738,-5.92945048108615,0.058554388816896,"CRYZL1","crystallin zeta like 1",TRUE
+"1554767_s_at",0.996224607226304,0.981159358571705,0.0238834655662893,-5.93940565405272,0.00964703923125398,"CRYZL1","crystallin zeta like 1",TRUE
+"208660_at",0.889389445320988,0.55717273056197,-0.596065048858918,-5.7680991062056,-0.167869783571755,"CS","citrate synthase",TRUE
+"221139_s_at",0.54295328972902,0.0459515433136409,-2.11451425750925,-3.96903085083659,-1.31193975999095,"CSAD","cysteine sulfinic acid decarboxylase",TRUE
+"238764_at",0.630603891142543,0.1019238032043,-1.70634322217373,-4.61308154918445,-0.856555094271618,"CSAD","cysteine sulfinic acid decarboxylase",TRUE
+"1568620_at",0.992342196993659,0.964162335950392,-0.0454416810667796,-5.93867777154943,-0.0287219297936874,"CSAD","cysteine sulfinic acid decarboxylase",TRUE
+"220445_s_at",0.501485910520976,0.0320932638484297,2.28719003661124,-3.6697556879233,4.2371510901037,"CSAG2///CSAG3","CSAG family member 2///CSAG family member 3",TRUE
+"209981_at",0.953983577550391,0.788267397750806,0.271832883392156,-5.90375681714111,0.189688826736456,"CSDC2","cold shock domain containing C2",TRUE
+"219939_s_at",0.776074974591224,0.293565887963793,-1.0758599563866,-5.39111686946296,-0.414485033884025,"CSDE1","cold shock domain containing E1",TRUE
+"202646_s_at",0.816800680706682,0.368974301207446,-0.917082799263847,-5.5381411786318,-0.467987923098901,"CSDE1","cold shock domain containing E1",TRUE
+"222975_s_at",0.92247975200053,0.668727654874033,-0.433661072569841,-5.84849824766494,-0.221060422052581,"CSDE1","cold shock domain containing E1",TRUE
+"210765_at",0.508488499910913,0.033669018640786,-2.26445366255651,-3.70997174820341,-1.00145954663526,"CSE1L","chromosome segregation 1 like",TRUE
+"201112_s_at",0.813442508625161,0.363852768625029,-0.927122381044687,-5.52947905272002,-0.239812596319892,"CSE1L","chromosome segregation 1 like",TRUE
+"210766_s_at",0.864894115958506,0.493602740152523,-0.69610239347253,-5.70638922438822,-0.218574442480739,"CSE1L","chromosome segregation 1 like",TRUE
+"201111_at",0.91994485246627,0.659244415188615,-0.446957203597733,-5.84284815352338,-0.147987552856744,"CSE1L","chromosome segregation 1 like",TRUE
+"209716_at",0.839519981963042,0.428010590901234,0.807415177243664,-5.62705012331224,0.77848321263685,"CSF1","colony stimulating factor 1",TRUE
+"210557_x_at",0.862071199872697,0.484809606834672,0.710494491101834,-5.69675911474027,0.762591578532243,"CSF1","colony stimulating factor 1",TRUE
+"207082_at",0.929125618312698,0.688198513232966,0.406605614678919,-5.85947749178987,0.342621426256539,"CSF1","colony stimulating factor 1",TRUE
+"211839_s_at",0.953553103224247,0.785739669184075,0.275164358518606,-5.90287242759675,0.302621336085867,"CSF1","colony stimulating factor 1",TRUE
+"203104_at",0.682539393883246,0.150306352736761,1.49006348578143,-4.91251505533113,0.976053244585903,"CSF1R","colony stimulating factor 1 receptor",TRUE
+"210229_s_at",0.308621629697291,0.00629938403452659,3.01751758623886,-2.27247868104949,2.5995151412524,"CSF2","colony stimulating factor 2",TRUE
+"210228_at",0.557589172116298,0.0525381289009883,2.04852009233838,-4.07948627706166,1.08839880383545,"CSF2","colony stimulating factor 2",TRUE
+"211287_x_at",0.668620158511127,0.134952108891705,1.55148895288089,-4.83070150387164,1.03897803591515,"CSF2RA","colony stimulating factor 2 receptor alpha subunit",TRUE
+"211286_x_at",0.673580489720054,0.139730222485685,1.53178439341513,-4.8572327421695,1.64698970189671,"CSF2RA","colony stimulating factor 2 receptor alpha subunit",TRUE
+"210340_s_at",0.729789891627758,0.212207214712913,1.28458151452184,-5.1664091861027,1.39501287141367,"CSF2RA","colony stimulating factor 2 receptor alpha subunit",TRUE
+"207085_x_at",0.750594407352788,0.243559574026727,1.19804197515665,-5.26378065229416,1.3201293787704,"CSF2RA","colony stimulating factor 2 receptor alpha subunit",TRUE
+"205159_at",0.772988605474261,0.283623795516297,-1.09886656959877,-5.36806584018235,-0.831955593088538,"CSF2RB","colony stimulating factor 2 receptor beta common subunit",TRUE
+"207442_at",0.990810941805126,0.95622533972004,-0.0555155164026681,-5.93818247702867,-0.0176528527076054,"CSF3","colony stimulating factor 3",TRUE
+"203591_s_at",0.899808883319249,0.591988679944584,-0.543830751107095,-5.79665127041355,-0.43382706776007,"CSF3R","colony stimulating factor 3 receptor",TRUE
+"1553297_a_at",0.988125343464583,0.943268880684901,-0.0719733254250625,-5.93716073093972,-0.0394603914555258,"CSF3R","colony stimulating factor 3 receptor",TRUE
+"1569387_at",0.486821797225537,0.0287062363832671,2.33974292358587,-3.57590654551075,1.33019819451024,"CSGALNACT1","chondroitin sulfate N-acetylgalactosaminyltransferase 1",TRUE
+"219049_at",0.775289966640737,0.291682023114768,1.08017579643543,-5.38682585258769,2.20090785949674,"CSGALNACT1","chondroitin sulfate N-acetylgalactosaminyltransferase 1",TRUE
+"239077_at",0.806649582904638,0.347713127533821,0.959394516258676,-5.50104839999683,0.341354977024746,"CSGALNACT2","chondroitin sulfate N-acetylgalactosaminyltransferase 2",TRUE
+"222235_s_at",0.899046682581382,0.589010053054016,-0.54823821659251,-5.79434015220133,-0.213909059368588,"CSGALNACT2","chondroitin sulfate N-acetylgalactosaminyltransferase 2",TRUE
+"218871_x_at",0.984397001287044,0.923983479400007,0.0965096091869849,-5.93514794178782,0.0370178917527131,"CSGALNACT2","chondroitin sulfate N-acetylgalactosaminyltransferase 2",TRUE
+"208357_x_at",0.869082033398093,0.505911545948559,0.676199953341716,-5.71939635174915,0.266256837761502,"CSH1","chorionic somatomammotropin hormone 1",TRUE
+"207770_x_at",0.799008022536007,0.333620091862877,0.988417418429231,-5.47472127509782,0.482442899911349,"CSH2///CSH1","chorionic somatomammotropin hormone 2///chorionic somatomammotropin hormone 1",TRUE
+"208341_x_at",0.80876559661836,0.351922127282074,0.950882536987103,-5.50863374333233,0.49509443438795,"CSH2///CSH1","chorionic somatomammotropin hormone 2///chorionic somatomammotropin hormone 1",TRUE
+"208342_x_at",0.988802593747325,0.946215820909821,0.068228382287747,-5.93741640157997,0.0236500320775153,"CSH2///CSH1","chorionic somatomammotropin hormone 2///chorionic somatomammotropin hormone 1",TRUE
+"208294_x_at",0.639656559005154,0.110078254479735,1.66456992186436,-4.67334687150731,0.490284874249071,"CSHL1","chorionic somatomammotropin hormone like 1",TRUE
+"208293_x_at",0.700890836612645,0.172597973921402,-1.40940259178458,-5.01588433720941,-0.721726406536132,"CSHL1","chorionic somatomammotropin hormone like 1",TRUE
+"205958_x_at",0.855405088766616,0.468442942299841,0.737692025865372,-5.67804881714082,0.272575795911518,"CSHL1","chorionic somatomammotropin hormone like 1",TRUE
+"208295_x_at",0.914699497587202,0.640632608342144,0.473294870060967,-5.83116247794323,0.310176318660585,"CSHL1","chorionic somatomammotropin hormone like 1",TRUE
+"207285_x_at",0.952613441433926,0.782871060066324,0.278948964052203,-5.90185477344231,0.182185263771522,"CSHL1","chorionic somatomammotropin hormone like 1",TRUE
+"202329_at",0.490107603095446,0.0292690629858557,-2.33062841671519,-3.59227132876097,-0.879473865489567,"CSK","c-src tyrosine kinase",TRUE
+"241960_at",0.760463372361683,0.259538116657869,1.15714053017832,-5.30774835242759,0.678790912896146,"CSMD1","CUB and Sushi multiple domains 1",TRUE
+"1562330_s_at",0.77673212102109,0.294172179479141,1.07447519936655,-5.39249040908247,0.619841776709658,"CSMD1","CUB and Sushi multiple domains 1",TRUE
+"231223_at",0.896229101808264,0.580123503381332,0.561453596310015,-5.78730191436206,0.548236204881154,"CSMD1","CUB and Sushi multiple domains 1",TRUE
+"1562329_at",0.986720888319514,0.938011806153545,-0.0786566206328523,-5.9366705366308,-0.0866031164487444,"CSMD1","CUB and Sushi multiple domains 1",TRUE
+"1553405_a_at",0.997864116645955,0.990034510682697,0.0126319154255569,-5.93960576267959,0.00817961735947659,"CSMD1","CUB and Sushi multiple domains 1",TRUE
+"1557143_at",0.768243637564985,0.271382855343944,1.12800967282012,-5.33824494081584,0.581678325099764,"CSMD2","CUB and Sushi multiple domains 2",TRUE
+"233145_at",0.917601067333473,0.650619855094957,-0.459120825510819,-5.83753276134635,-0.182196009206189,"CSMD2","CUB and Sushi multiple domains 2",TRUE
+"1570169_at",0.936992192746977,0.719058012464914,-0.36434023586183,-5.87523487486615,-0.171764695529953,"CSMD2","CUB and Sushi multiple domains 2",TRUE
+"1569696_at",0.716472449896956,0.192154911719773,1.34524163586287,-5.09471731725815,0.657423862048836,"CSMD2-AS1","CSMD2 antisense RNA 1",TRUE
+"240228_at",0.799008022536007,0.333518783723068,0.988629069314721,-5.47452665861607,0.527752549940604,"CSMD3","CUB and Sushi multiple domains 3",TRUE
+"208350_at",0.597654932724127,0.0740874805583258,1.87463417061946,-4.35921627785706,1.39906241240492,"CSN1S1","casein alpha s1",TRUE
+"1553080_at",0.722442821599878,0.1990599035681,1.32381871167077,-5.120354985478,0.901736420752611,"CSN1S2AP","casein alpha s2-like A, pseudogene",TRUE
+"207951_at",0.766550448794594,0.267832182678615,1.13664232958168,-5.32927900836497,0.340121748790938,"CSN2","casein beta",TRUE
+"207803_s_at",0.78885145722244,0.315129659471621,-1.02781003702145,-5.43784864842321,-0.629428550029111,"CSN3","casein kappa",TRUE
+"213086_s_at",0.689950875648652,0.159333403243875,-1.45630645092613,-4.95634477325035,-0.408374313513038,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"213860_x_at",0.725181883744124,0.203810371500436,-1.30941514515402,-5.13739725046591,-0.335278605406478,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"208865_at",0.757490878759892,0.253688440438452,-1.17189083106102,-5.29204619742736,-0.309854710054644,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"235464_at",0.765116907435848,0.265032910624035,-1.14350756365559,-5.32210571015691,-0.387940506728116,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"208867_s_at",0.82881747286857,0.399391542484587,-0.859272776259612,-5.58632036034097,-0.301608824858414,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"1556006_s_at",0.839519981963042,0.427656769324624,-0.808042760470883,-5.62657140418334,-0.357289445583662,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"206562_s_at",0.841088238127348,0.430935616180364,-0.802239286391403,-5.63098496042337,-0.279354782373222,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"240221_at",0.86373265375983,0.489251034054722,-0.703206404877837,-5.70165923346174,-0.344378765837778,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"208866_at",0.867447813467579,0.499970975681696,-0.68577070781675,-5.7131864365636,-0.234208213582477,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"1556007_s_at",0.940044918888428,0.731485638912436,-0.347512722274257,-5.88103382429206,-0.178545244356842,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"243338_at",0.945764550538403,0.755115371158916,-0.315792596206693,-5.89122751238328,-0.144119283010214,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"226920_at",0.948429371744093,0.76562368972786,0.301793860814059,-5.89541910285227,0.0762237645537054,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"205764_at",0.95194340202313,0.780360968886698,0.282263985785917,-5.90095205196132,0.23277344642268,"CSNK1A1","casein kinase 1 alpha 1",TRUE
+"1559651_at",0.966593471043185,0.844522904284825,-0.198423751557603,-5.92052501248293,-0.128473105054994,"CSNK1A1P1","casein kinase 1 alpha 1 pseudogene 1",TRUE
+"208774_at",0.364513221153898,0.0106536673485954,-2.78906846955103,-2.72859091550795,-1.12265912238677,"CSNK1D","casein kinase 1 delta",TRUE
+"213522_s_at",0.429276772897071,0.0187736386399344,2.5357816799422,-3.21549437832177,1.6134928707102,"CSNK1D","casein kinase 1 delta",TRUE
+"207945_s_at",0.937623890519979,0.723986419128463,0.357654414945919,-5.87757130792553,0.122589935527655,"CSNK1D","casein kinase 1 delta",TRUE
+"226858_at",0.925232559829186,0.676134740337908,0.423330952928465,-5.85277228513446,0.148094649170748,"CSNK1E","casein kinase 1 epsilon",TRUE
+"222015_at",0.92996437978379,0.690608120813813,0.403279153385963,-5.86077936982158,0.167218703509004,"CSNK1E","casein kinase 1 epsilon",TRUE
+"226888_at",0.396220771188728,0.0136443096021208,-2.67946907242837,-2.94195461245975,-0.773496566841672,"CSNK1G1","casein kinase 1 gamma 1",TRUE
+"231920_s_at",0.565043084457947,0.0562592024828175,-2.01444357182714,-4.1356218797949,-0.698626292019981,"CSNK1G1","casein kinase 1 gamma 1",TRUE
+"221673_s_at",0.68041487556515,0.148016041504946,-1.49888980011293,-4.90092167808835,-0.38991302351775,"CSNK1G1","casein kinase 1 gamma 1",TRUE
+"220640_at",0.856631989847095,0.470653198360309,-0.733986867502443,-5.68063702444416,-0.397873727057112,"CSNK1G1","casein kinase 1 gamma 1",TRUE
+"202573_at",0.695005304830231,0.164527677359067,-1.43757826446086,-4.98030930658792,-0.402745783239116,"CSNK1G2","casein kinase 1 gamma 2",TRUE
+"202574_s_at",0.983115194220002,0.917781105477392,0.104412892717709,-5.9343748877501,0.0418313678351971,"CSNK1G2","casein kinase 1 gamma 2",TRUE
+"1553871_at",0.874305976196739,0.520298007270476,0.653279984194072,-5.7339279836934,0.156977648114254,"CSNK1G2-AS1","CSNK1G2 antisense RNA 1",TRUE
+"227767_at",0.798401804604592,0.332615074969159,-0.990519044156702,-5.47278711561247,-0.359537694625677,"CSNK1G3","casein kinase 1 gamma 3",TRUE
+"220768_s_at",0.954577684533304,0.79281822671576,-0.265842904010018,-5.9053200378971,-0.0952161171377082,"CSNK1G3","casein kinase 1 gamma 3",TRUE
+"229702_at",0.967737940016834,0.848317219737116,-0.193516925991662,-5.92145999359887,-0.102072907720293,"CSNK1G3","casein kinase 1 gamma 3",TRUE
+"212073_at",0.9089753392553,0.621792565048764,0.500306185423359,-5.81849842914445,0.339716593760969,"CSNK2A1","casein kinase 2 alpha 1",TRUE
+"212072_s_at",0.928267401642659,0.684889016593779,-0.411182000747621,-5.85766923176669,-0.166090717593471,"CSNK2A1","casein kinase 2 alpha 1",TRUE
+"212075_s_at",0.963675080804196,0.834186163304623,-0.211816971294628,-5.91785429380791,-0.0981911473451635,"CSNK2A1","casein kinase 2 alpha 1",TRUE
+"206075_s_at",0.988224361618126,0.943958569083351,-0.0710967835615199,-5.9372217969739,-0.0326662380739648,"CSNK2A1","casein kinase 2 alpha 1",TRUE
+"203575_at",0.716245563733659,0.1919943599032,1.3457468860791,-5.09410849566177,0.574472363553806,"CSNK2A2","casein kinase 2 alpha 2",TRUE
+"224922_at",0.98586793523628,0.931408459651855,-0.0870566678340995,-5.93599276987534,-0.0287703233850287,"CSNK2A2","casein kinase 2 alpha 2",TRUE
+"201390_s_at",0.981287946950833,0.911489523069868,-0.112436818053205,-5.9335278853831,-0.0286899075593983,"CSNK2B","casein kinase 2 beta",TRUE
+"204736_s_at",0.213457581202441,0.0025532923293351,3.39991272401849,-1.48196523850622,2.4623123070824,"CSPG4","chondroitin sulfate proteoglycan 4",TRUE
+"214297_at",0.439046404588921,0.0201877029928952,2.50267652380645,-3.27744087902175,1.86269553972326,"CSPG4","chondroitin sulfate proteoglycan 4",TRUE
+"211461_at",0.562969692121027,0.0555916482443791,2.02040603846582,-4.12584469572928,0.579342945955203,"CSPG4P1Y","chondroitin sulfate proteoglycan 4 pseudogene 1, Y-linked",TRUE
+"1561960_at",0.936992192746977,0.718955981550838,-0.364478827713816,-5.87518599041421,-0.253519953136121,"CSPG4P5","chondroitin sulfate proteoglycan 4 pseudogene 5",TRUE
+"39966_at",0.548055506319763,0.0483150899032695,-2.08991043761179,-4.0104749431368,-1.16195352905326,"CSPG5","chondroitin sulfate proteoglycan 5",TRUE
+"205344_at",0.720018659171833,0.195959310296441,-1.33336518446655,-5.10897306642452,-0.872757717020179,"CSPG5","chondroitin sulfate proteoglycan 5",TRUE
+"220072_at",0.760237493549547,0.258432411696538,1.15990959398926,-5.30481389393545,0.431775050654007,"CSPP1","centrosome and spindle pole associated protein 1",TRUE
+"227105_at",0.769258076576208,0.276189524905916,-1.11645405730341,-5.35015206772136,-0.512336978907955,"CSPP1","centrosome and spindle pole associated protein 1",TRUE
+"242041_at",0.84674453317787,0.445201007686588,-0.777302195872225,-5.64960893069165,-0.386977700509648,"CSPP1","centrosome and spindle pole associated protein 1",TRUE
+"1554873_at",0.867099100798202,0.498988696652735,0.687359430380547,-5.71214753278357,0.459365487412698,"CSPP1","centrosome and spindle pole associated protein 1",TRUE
+"221925_s_at",0.986611998306681,0.93760618404087,0.0791724347892799,-5.9366308964955,0.0264629382908819,"CSPP1","centrosome and spindle pole associated protein 1",TRUE
+"225557_at",0.823518986434235,0.390574683808435,-0.875725103992306,-5.57290496616706,-0.388706505612037,"CSRNP1","cysteine and serine rich nuclear protein 1",TRUE
+"221260_s_at",0.360736459722853,0.0103645188817905,-2.80116982319967,-2.70480085333477,-1.119195918727,"CSRNP2","cysteine and serine rich nuclear protein 2",TRUE
+"225042_s_at",0.495146831905934,0.0301592434177105,-2.31653634053482,-3.61750092479595,-0.730246534389812,"CSRNP2","cysteine and serine rich nuclear protein 2",TRUE
+"1558121_at",0.298372619814585,0.0054927918424424,3.07626746037851,-2.15299705006328,2.28164282640263,"CSRNP3","cysteine and serine rich nuclear protein 3",TRUE
+"235355_at",0.650298942402444,0.120447174076217,1.61507035783952,-4.743281246425,2.29749736009473,"CSRNP3","cysteine and serine rich nuclear protein 3",TRUE
+"235018_at",0.816358096928248,0.367573911845992,0.919818667085558,-5.53578928932871,0.73348175932827,"CSRNP3","cysteine and serine rich nuclear protein 3",TRUE
+"1558122_s_at",0.834265235157814,0.412366900132872,0.835479505349092,-5.60530212512596,0.70746011451065,"CSRNP3","cysteine and serine rich nuclear protein 3",TRUE
+"235017_s_at",0.845738161733126,0.443703752771813,0.779896287666504,-5.64769738260369,0.482730885800729,"CSRNP3","cysteine and serine rich nuclear protein 3",TRUE
+"220462_at",0.89085645983207,0.55991628240319,0.591889531616016,-5.77047465963986,0.477220107201961,"CSRNP3","cysteine and serine rich nuclear protein 3",TRUE
+"238985_at",0.943427753153089,0.74611460532857,0.327834335367806,-5.88747134604333,0.217658295382066,"CSRNP3","cysteine and serine rich nuclear protein 3",TRUE
+"200621_at",0.54295328972902,0.0460912515235922,-2.11302865422545,-3.97154208257185,-1.03084050625431,"CSRP1","cysteine and glycine rich protein 1",TRUE
+"211126_s_at",0.314168657577402,0.0067114584737157,2.99024265760081,-2.32766564717832,2.73048438246637,"CSRP2","cysteine and glycine rich protein 2",TRUE
+"207030_s_at",0.358427723880268,0.0100224022187732,2.81590936323882,-2.67576467981418,3.25829321327107,"CSRP2","cysteine and glycine rich protein 2",TRUE
+"205553_s_at",0.949038895598021,0.770305350732303,-0.295577085592504,-5.89722017198153,-0.131049820698024,"CSRP3","cysteine and glycine rich protein 3",TRUE
+"206224_at",0.961212424803935,0.823785275095111,-0.225333431840808,-5.91498299015618,-0.342004047984843,"CST1","cystatin SN",TRUE
+"233797_s_at",0.588874307905413,0.06759533893762,-1.92172205158485,-4.28514589474531,-1.6117518983449,"CST11","cystatin 11",TRUE
+"233968_at",0.937462538530338,0.722874693900324,0.359161107519409,-5.8770485078104,0.164016850840006,"CST11","cystatin 11",TRUE
+"1558493_at",0.801455134542848,0.338172289966228,0.978952382258846,-5.48338575187774,0.380613920320685,"CST13P","cystatin 13, pseudogene",TRUE
+"208555_x_at",0.554642754132296,0.0510557591415159,-2.06269821472545,-4.05594788065445,-2.43207405395868,"CST2","cystatin SA",TRUE
+"237623_at",0.864175199827872,0.491437201841926,0.699633047738338,-5.70404417071469,0.880526045654445,"CST3","cystatin C",TRUE
+"230343_at",0.976371465776674,0.886442408672509,-0.144461016819292,-5.92952407625003,-0.145719376367516,"CST3","cystatin C",TRUE
+"201360_at",0.976371465776674,0.886977153192554,0.143775818349267,-5.92962017473418,0.201992102276273,"CST3","cystatin C",TRUE
+"206994_at",0.76719388846109,0.269097402642965,-1.13355666112457,-5.33249073188596,-1.40483121229898,"CST4","cystatin S",TRUE
+"207925_at",0.774230543658252,0.288758412313598,-1.08691347774162,-5.38009627538518,-0.810256698485325,"CST5","cystatin D",TRUE
+"231248_at",0.357715436092381,0.00968301500533559,2.83101187418026,-2.64594633783705,3.0133904314871,"CST6","cystatin E/M",TRUE
+"206595_at",0.406049718268978,0.0152598416376017,2.6294023454862,-3.03810009453385,3.84549563832748,"CST6","cystatin E/M",TRUE
+"210140_at",0.812896635201594,0.361888995387112,0.930996927584655,-5.52611289561667,0.813086226555666,"CST7","cystatin F",TRUE
+"220627_at",0.593337376134677,0.0700005744228767,1.90383227148823,-4.31343795795792,1.16415579568355,"CST8","cystatin 8",TRUE
+"1554386_at",0.870517518639056,0.509620471267096,-0.670256621967056,-5.72321060930748,-0.858019318849751,"CST9","cystatin 9",TRUE
+"230829_at",0.931121627074226,0.695009331507528,0.397215184616452,-5.8631255333387,0.345179573268533,"CST9L","cystatin 9-like",TRUE
+"204971_at",0.612866720637562,0.0844628736946211,1.80637360413997,-4.46427459784946,2.04929112072688,"CSTA","cystatin A",TRUE
+"201201_at",0.226835660387594,0.00282118425356313,3.35815746162929,-1.56959795033083,0.882264664029806,"CSTB","cystatin B",TRUE
+"236449_at",0.576675680499645,0.0613457246748327,1.9709689927377,-4.20632481615811,1.06489566098532,"CSTB","cystatin B",TRUE
+"32723_at",0.559167054471987,0.0528982730247369,-2.04512951005308,-4.08509952521641,-0.988307599801821,"CSTF1","cleavage stimulation factor subunit 1",TRUE
+"202190_at",0.727294834785485,0.207685396511857,-1.29785813693607,-5.1509573826752,-0.569912725472113,"CSTF1","cleavage stimulation factor subunit 1",TRUE
+"238821_at",0.822173415758858,0.386413269765496,-0.883574046639075,-5.56642162996113,-0.340010444335972,"CSTF2","cleavage stimulation factor subunit 2",TRUE
+"204459_at",0.867026157046741,0.498598506533907,0.687991010499411,-5.71173388939481,0.207950989892218,"CSTF2","cleavage stimulation factor subunit 2",TRUE
+"212905_at",0.527546822913581,0.0399957673320026,-2.18197550912035,-3.85382732467068,-0.890040211323115,"CSTF2T","cleavage stimulation factor subunit 2, tau variant",TRUE
+"212901_s_at",0.690823350461169,0.160424376558485,-1.45233245160312,-4.96145099415383,-0.580988776594081,"CSTF2T","cleavage stimulation factor subunit 2, tau variant",TRUE
+"229666_s_at",0.808585848781544,0.351601962513203,0.951527582632043,-5.50806108654526,0.441148391420619,"CSTF3","cleavage stimulation factor subunit 3",TRUE
+"229665_at",0.929077233612709,0.687236772912644,0.40793459862084,-5.85895442444926,0.198636153752286,"CSTF3","cleavage stimulation factor subunit 3",TRUE
+"203947_at",0.985709215004606,0.931060055078886,-0.0875000424655439,-5.93595508793868,-0.0275971029216162,"CSTF3","cleavage stimulation factor subunit 3",TRUE
+"1560202_at",0.714373075234728,0.189346949812466,-1.3541264809314,-5.08398326266875,-1.35774126325673,"CSTF3-AS1","CSTF3 antisense RNA 1 (head to head)",TRUE
+"234803_at",0.813442508625161,0.363940497550638,-0.926949617622527,-5.52962884665344,-0.622129889471036,"CSTL1","cystatin like 1",TRUE
+"235700_at",0.830635993561085,0.404508714486648,0.849831147930805,-5.59391217979178,1.45214077572833,"CT45A8///CT45A9///CT45A10///CT45A7///CT45A2///CT45A1///CT45A6///CT45A5///CT45A3","cancer/testis antigen family 45, member A8///cancer/testis antigen family 45, member A9///cancer/testis antigen family 45, member A10///cancer/testis antigen family 45, member A7///cancer/testis antigen family 45, member A2///cancer/testis antigen family 45, member A1///cancer/testis antigen family 45, member A6///cancer/testis antigen family 45, member A5///cancer/testis antigen family 45, member A3",TRUE
+"1567912_s_at",0.90574880691281,0.612065865002425,0.51439932754891,-5.81161867189697,1.04539429136684,"CT45A8///CT45A9///CT45A10///CT45A7///CT45A2///CT45A1///CT45A6///CT45A5///CT45A3","cancer/testis antigen family 45, member A8///cancer/testis antigen family 45, member A9///cancer/testis antigen family 45, member A10///cancer/testis antigen family 45, member A7///cancer/testis antigen family 45, member A2///cancer/testis antigen family 45, member A1///cancer/testis antigen family 45, member A6///cancer/testis antigen family 45, member A5///cancer/testis antigen family 45, member A3",TRUE
+"231568_at",0.958587459575795,0.812169313616586,0.240479977192473,-5.91155550610907,0.150234574811524,"CT47A12///CT47A1///CT47A2///CT47A3///CT47A4///CT47A5///CT47A6///CT47A8///CT47A9///CT47A10///CT47A7///CT47A11","cancer/testis antigen family 47, member A12///cancer/testis antigen family 47, member A1///cancer/testis antigen family 47, member A2///cancer/testis antigen family 47, member A3///cancer/testis antigen family 47, member A4///cancer/testis antigen family 47, member A5///cancer/testis antigen family 47, member A6///cancer/testis antigen family 47, member A8///cancer/testis antigen family 47, member A9///cancer/testis antigen family 47, member A10///cancer/testis antigen family 47, member A7///cancer/testis antigen family 47, member A11",TRUE
+"221121_at",0.980808506518944,0.909719221455779,-0.114695900265571,-5.93327812298074,-0.0848065982999469,"CT55","cancer/testis antigen 55",TRUE
+"214418_at",0.940227139261806,0.732163480119694,0.34659787685726,-5.88134132547374,0.219999506974372,"CT62","cancer/testis antigen 62",TRUE
+"1559258_a_at",0.778955753047799,0.299934575076461,1.06141485381226,-5.40536706895913,1.15007151902724,"CT83","cancer/testis antigen 83",TRUE
+"211674_x_at",0.160119467990575,0.0012622129072508,3.692253240532,-0.861874912011664,6.02293349942598,"CTAG1A///CTAG1B","cancer/testis antigen 1A///cancer/testis antigen 1B",TRUE
+"210546_x_at",0.178066946115198,0.00160997068590424,3.59171096556186,-1.07627229224931,5.88184807877333,"CTAG1A///CTAG1B","cancer/testis antigen 1A///cancer/testis antigen 1B",TRUE
+"217339_x_at",0.423831804975868,0.0178602373784069,2.55842707237202,-3.1728805205786,3.89835101651734,"CTAG1A///CTAG1B","cancer/testis antigen 1A///cancer/testis antigen 1B",TRUE
+"215733_x_at",0.170994566769966,0.0014448923611838,3.63645648898782,-0.980983334933962,5.96265457929117,"CTAG2","cancer/testis antigen 2",TRUE
+"207337_at",0.552420073963858,0.050082835010877,2.07220523246607,-4.04010513480288,2.72291129974663,"CTAG2","cancer/testis antigen 2",TRUE
+"220957_at",0.917227762565585,0.650019645471033,-0.45996993124429,-5.83715648707262,-0.119573749124211,"CTAGE1","cutaneous T-cell lymphoma-associated antigen 1",TRUE
+"217332_at",0.93647371549118,0.716553730746983,-0.36774399099193,-5.87402898455616,-0.25589052785336,"CTAGE11P","CTAGE family member 11, pseudogene",TRUE
+"235790_at",0.624331975868069,0.095662254985169,1.74039437158526,-4.5631294862547,0.980999710150269,"CTAGE5","CTAGE family member 5, ER export factor",TRUE
+"215930_s_at",0.837337084923913,0.419972881752467,-0.821752609270015,-5.61602652170064,-0.371035642742477,"CTAGE5","CTAGE family member 5, ER export factor",TRUE
+"204055_s_at",0.97689149311934,0.889973935820184,-0.139937165121917,-5.93015010926328,-0.107994768658416,"CTAGE5","CTAGE family member 5, ER export factor",TRUE
+"215549_x_at",0.948815741515659,0.76717633668126,0.299730768155251,-5.8960209240568,0.146053573571301,"CTAGE8///CTAGE4///CTAGE9","CTAGE family member 8///CTAGE family member 4///CTAGE family member 9",TRUE
+"214355_x_at",0.879161148925378,0.53286716259635,0.633539738421882,-5.74605805016305,0.23673847186719,"CTAGE8///CTAGE4///CTAGE9///CTAGE15","CTAGE family member 8///CTAGE family member 4///CTAGE family member 9///CTAGE family member 15",TRUE
+"1561413_at",0.56861088242915,0.0584103359297333,1.99564882571313,-4.16631499669447,0.850606828796317,"CTB-113P19.1","uncharacterized LOC101927096",TRUE
+"233237_at",0.716472449896956,0.192473421820478,-1.34424027807471,-5.09592337752053,-0.718683679676312,"CTB-12O2.1","uncharacterized LOC101927115",TRUE
+"233238_s_at",0.933323864604092,0.705058538266901,0.383425624608584,-5.86833037016465,0.243464503687242,"CTB-12O2.1","uncharacterized LOC101927115",TRUE
+"1565909_at",0.632216562924782,0.103116158551406,1.70006198836759,-4.62221523930766,0.914074393844213,"CTB-49A3.2","uncharacterized CTB-49A3.2",TRUE
+"212863_x_at",0.331069603215022,0.00804796872101158,-2.91167710658741,-2.48556959395539,-0.795440201482171,"CTBP1","C-terminal binding protein 1",TRUE
+"203392_s_at",0.358427723880268,0.0101748806055173,-2.80928192105188,-2.68882847928061,-0.987731757875355,"CTBP1","C-terminal binding protein 1",TRUE
+"213980_s_at",0.393258278493143,0.0134496582213889,-2.68587456580031,-2.92959221883869,-0.739348373979645,"CTBP1","C-terminal binding protein 1",TRUE
+"1557714_at",0.998347572104896,0.993154157152566,0.00867743026064169,-5.93964680603545,0.00474465052002859,"CTBP1","C-terminal binding protein 1",TRUE
+"1563571_at",0.995091556086988,0.976946036536577,0.0292259557731153,-5.93926746117829,0.00838521514833923,"CTBP1-AS","CTBP1 antisense RNA",TRUE
+"232066_x_at",0.546181066868403,0.0473806456361561,-2.09950565694428,-3.99434918874765,-0.557118476817143,"CTBP1-AS2","CTBP1 antisense RNA 2 (head to head)",TRUE
+"237642_at",0.831875452294783,0.406758996974519,-0.845703378033683,-5.59720666476348,-0.348224256041512,"CTBP1-AS2","CTBP1 antisense RNA 2 (head to head)",TRUE
+"210835_s_at",0.805746717966166,0.345438105794509,0.964024526459968,-5.49689646403926,0.350646681072272,"CTBP2","C-terminal binding protein 2",TRUE
+"201220_x_at",0.881178591455433,0.537795790419975,0.62586823846039,-5.7506754808694,0.208729763933299,"CTBP2","C-terminal binding protein 2",TRUE
+"201218_at",0.88782282220852,0.553131529377007,0.602235065513417,-5.76455930193507,0.184668112969124,"CTBP2","C-terminal binding protein 2",TRUE
+"210554_s_at",0.901781358899845,0.598843389357637,0.533728916673704,-5.80187988987847,0.185934556524508,"CTBP2","C-terminal binding protein 2",TRUE
+"201219_at",0.947062793209778,0.759677605775833,0.309707237029964,-5.89307276251957,0.129636761674316,"CTBP2","C-terminal binding protein 2",TRUE
+"215377_at",0.976422537443518,0.887700794185962,0.142848688269155,-5.92974947800418,0.0866976006559455,"CTBP2","C-terminal binding protein 2",TRUE
+"218923_at",0.953902670233338,0.78710947215864,-0.273358604368657,-5.90335311931989,-0.117782338658159,"CTBS","chitobiase",TRUE
+"218924_s_at",0.992294016310421,0.963778975590497,0.0459281323593786,-5.9386561252497,0.0219037680881229,"CTBS","chitobiase",TRUE
+"219881_s_at",0.873185408141357,0.51761887998664,-0.657521337958241,-5.73127511424058,-0.358027880597868,"CTC-338M12.4","uncharacterized LOC101928649",TRUE
+"219880_at",0.917806614232276,0.651067755518954,-0.458487412102252,-5.83781300967773,-0.289987837785155,"CTC-338M12.4","uncharacterized LOC101928649",TRUE
+"240875_at",0.819018525257656,0.375210952181101,0.904981558200479,-5.54846649182598,0.389795323801501,"CTC1","CTS telomere maintenance complex component 1",TRUE
+"235523_at",0.925163682061836,0.676067485196133,-0.423424536673048,-5.85273401977901,-0.415480274986944,"CTC1","CTS telomere maintenance complex component 1",TRUE
+"219435_at",0.930899509890345,0.694328205173088,0.398152640955966,-5.86276511669591,0.181737310512369,"CTC1","CTS telomere maintenance complex component 1",TRUE
+"202521_at",0.591331966259927,0.0688970302448354,-1.91197215962127,-4.30058779306064,-0.508639003302713,"CTCF","CCCTC-binding factor",TRUE
+"1552368_at",0.986889306520757,0.939443969384977,-0.0768355672348697,-5.9368084130461,-0.0702800367086747,"CTCFL","CCCTC-binding factor like",TRUE
+"1562811_at",0.734730148360473,0.219682587063753,1.26310384600442,-5.19111876846579,0.799174874242887,"CTD-2194D22.4","uncharacterized LOC101929081",TRUE
+"1562701_at",0.606900628956089,0.0804179256880225,-1.83207026323964,-4.42505256563937,-1.05575438159396,"CTD-2297D10.2","uncharacterized LOC101929176",TRUE
+"240707_at",0.974982245454858,0.877627447339568,-0.155766594309435,-5.92787266021627,-0.110017958080122,"CTD-2350J17.1","uncharacterized LOC101929472",TRUE
+"1558402_at",0.866611803190887,0.497833507332471,0.689230090101538,-5.7109213195149,0.506389856479468,"CTD-3080P12.3","uncharacterized LOC101928857",TRUE
+"200035_at",0.643688366500038,0.114355489922165,1.64369515880498,-4.70303668871999,0.62624986232376,"CTDNEP1","CTD nuclear envelope phosphatase 1",TRUE
+"205035_at",0.597654932724127,0.0750289574671566,-1.86810804034721,-4.36938022213897,-0.636605132116022,"CTDP1","CTD phosphatase subunit 1",TRUE
+"217844_at",0.531568174205602,0.0417379455302176,-2.16135073862609,-3.88928842934143,-0.69716359761351,"CTDSP1","CTD small phosphatase 1",TRUE
+"208735_s_at",0.914746370982129,0.640818995500282,0.4730294528283,-5.83128350711308,0.16336363316301,"CTDSP2","CTD small phosphatase 2",TRUE
+"203445_s_at",0.915569510513076,0.644083127211438,-0.468386859233839,-5.83338976354088,-0.147429255160754,"CTDSP2","CTD small phosphatase 2",TRUE
+"213597_s_at",0.51531387545335,0.0358698838386586,2.23427279058673,-3.76298610100471,1.80465083821707,"CTDSPL","CTD small phosphatase like",TRUE
+"201905_s_at",0.642021982677251,0.112324601640334,1.65352322827447,-4.68909403553104,0.676194408045582,"CTDSPL","CTD small phosphatase like",TRUE
+"201904_s_at",0.646392036827936,0.117399206979298,1.6292370063177,-4.72343191644234,0.927363083430318,"CTDSPL","CTD small phosphatase like",TRUE
+"201906_s_at",0.743208164516614,0.233300077322335,1.22537672328323,-5.23365689816406,0.687069844550562,"CTDSPL","CTD small phosphatase like",TRUE
+"214187_x_at",0.821710721148425,0.38438566873162,0.887418328159299,-5.56322663136201,0.731561071505673,"CTDSPL","CTD small phosphatase like",TRUE
+"223270_at",0.822173415758858,0.386464591110659,0.883476913714114,-5.56650219099732,0.299053037898632,"CTDSPL2","CTD small phosphatase like 2",TRUE
+"1555106_a_at",0.85334340854827,0.460899854075147,0.750415530306536,-5.66906686231558,0.309202159387315,"CTDSPL2","CTD small phosphatase like 2",TRUE
+"223271_s_at",0.856040367116797,0.46937785396972,0.736123530542588,-5.67914598593611,0.238649412080624,"CTDSPL2","CTD small phosphatase like 2",TRUE
+"239133_at",0.978438521100347,0.896301565319157,0.131838942010655,-5.9312211341034,0.0434855639736114,"CTDSPL2","CTD small phosphatase like 2",TRUE
+"206813_at",0.613905708719203,0.0848719624746312,1.80383443148749,-4.46812854386654,1.31799446435621,"CTF1","cardiotrophin 1",TRUE
+"209101_at",0.828407100606296,0.39822002792344,0.86144523609247,-5.58456247635312,2.03914700165195,"CTGF","connective tissue growth factor",TRUE
+"217127_at",0.686747966354964,0.155235544659184,1.47143288528183,-4.93680521119903,1.20043344743203,"CTH","cystathionine gamma-lyase",TRUE
+"206085_s_at",0.771153198056133,0.280014843525083,1.10736201694911,-5.35944430620749,0.777479660951336,"CTH","cystathionine gamma-lyase",TRUE
+"225681_at",0.358427723880268,0.010164169493979,2.8097443835629,-2.68791731456973,3.56643108081423,"CTHRC1","collagen triple helix repeat containing 1",TRUE
+"204303_s_at",0.26149127436641,0.00390264069287592,-3.22158772661585,-1.85416702634103,-1.41374992849676,"CTIF","cap binding complex dependent translation initiation factor",TRUE
+"204302_s_at",0.92051722798026,0.662154546501009,0.44286840646247,-5.84460348599395,0.232509316330229,"CTIF","cap binding complex dependent translation initiation factor",TRUE
+"221331_x_at",0.623852759019384,0.0954867785329063,1.74137574878331,-4.56167895729631,1.26924661759452,"CTLA4","cytotoxic T-lymphocyte associated protein 4",TRUE
+"236341_at",0.720952283360079,0.197016298605908,-1.33009761508997,-5.11287661946714,-1.05570406904043,"CTLA4","cytotoxic T-lymphocyte associated protein 4",TRUE
+"231794_at",0.83766047465051,0.422231559937202,0.817706429235225,-5.61915592714132,0.43797493056989,"CTLA4","cytotoxic T-lymphocyte associated protein 4",TRUE
+"234362_s_at",0.896115372949367,0.577269777635529,-0.56571884568657,-5.78499561569506,-0.238567748038192,"CTLA4","cytotoxic T-lymphocyte associated protein 4",TRUE
+"234895_at",0.958574217853323,0.812125972958845,0.240536596495485,-5.91154227791773,0.105556630648343,"CTLA4","cytotoxic T-lymphocyte associated protein 4",TRUE
+"200764_s_at",0.630603891142543,0.101906669920077,-1.70643393330053,-4.61294945883664,-0.407440123101775,"CTNNA1","catenin alpha 1",TRUE
+"200765_x_at",0.637485146909712,0.10893549801874,-1.67026276304393,-4.66520052217823,-0.394980777413021,"CTNNA1","catenin alpha 1",TRUE
+"215883_at",0.659543761956192,0.127405428626097,1.58381867537558,-4.78659307146175,0.552403206193493,"CTNNA1","catenin alpha 1",TRUE
+"210844_x_at",0.663561605222859,0.131479851016773,-1.56617283947517,-4.81075639773402,-0.355449569171565,"CTNNA1","catenin alpha 1",TRUE
+"1558214_s_at",0.7580782491858,0.254735524536568,-1.16923212376943,-5.29488934470546,-0.348231284344697,"CTNNA1","catenin alpha 1",TRUE
+"217366_at",0.861962516141708,0.484521432664248,-0.710968696523244,-5.69643861683437,-0.409534046599869,"CTNNA1P1","catenin alpha 1 pseudogene 1",TRUE
+"205373_at",0.62986301194198,0.101143722935564,1.71048652269378,-4.60704285123004,1.42693472318285,"CTNNA2","catenin alpha 2",TRUE
+"236576_at",0.572291759946811,0.0599872716278953,1.98225733195517,-4.18806636461656,1.15678046725172,"CTNNA3","catenin alpha 3",TRUE
+"1554235_at",0.711989638658417,0.186005601747726,1.36483532374336,-5.07096713708663,0.926982154829846,"CTNNA3","catenin alpha 3",TRUE
+"241255_at",0.904092974845832,0.606259968721575,0.522861951495569,-5.80739801951793,0.420116903920363,"CTNNA3","catenin alpha 3",TRUE
+"220815_at",0.975265330414469,0.88009515324053,-0.152599621746273,-5.92834777541964,-0.106407142448148,"CTNNA3","catenin alpha 3",TRUE
+"202468_s_at",0.605074025447346,0.0789722587213948,1.84152665946229,-4.41051880893983,1.0798241737614,"CTNNAL1","catenin alpha like 1",TRUE
+"223679_at",0.700970248548011,0.172745736240254,1.40889663903836,-5.01651787247654,0.736702531241265,"CTNNB1","catenin beta 1",TRUE
+"201533_at",0.724970327905974,0.202652662001079,1.31290105314919,-5.13328717757207,0.60226598892587,"CTNNB1","catenin beta 1",TRUE
+"1554411_at",0.931370027472813,0.696629232400454,0.394987114938801,-5.86397878420583,0.289444403847175,"CTNNB1","catenin beta 1",TRUE
+"203081_at",0.952914447461733,0.784338642231597,0.277012241233292,-5.90237726864859,0.120339068386883,"CTNNBIP1","catenin beta interacting protein 1",TRUE
+"221021_s_at",0.860085676417428,0.47916153576898,-0.719818703027996,-5.69041988304321,-0.234045572237134,"CTNNBL1","catenin beta like 1",TRUE
+"209618_at",0.557502997422893,0.0522215851546521,-2.05151738118189,-4.07451906302353,-2.71284599465215,"CTNND2","catenin delta 2",TRUE
+"209617_s_at",0.627053909308516,0.097870765974455,-1.72817272794688,-4.58114287826834,-1.69617514955969,"CTNND2","catenin delta 2",TRUE
+"1566440_at",0.871451481476429,0.512724064835334,0.665301877829612,-5.72636577388486,0.300627225254694,"CTNND2","catenin delta 2",TRUE
+"204925_at",0.597654932724127,0.0739093968340072,1.87587674717586,-4.3572782280398,0.63714830466041,"CTNS","cystinosin, lysosomal cystine transporter",TRUE
+"36566_at",0.661974206478491,0.129825649358171,1.57328151644382,-4.80104765103702,0.416328067030069,"CTNS","cystinosin, lysosomal cystine transporter",TRUE
+"215459_at",0.816800680706682,0.368324551789246,-0.918351320294987,-5.53705149699466,-0.662461336385588,"CTNS","cystinosin, lysosomal cystine transporter",TRUE
+"202613_at",0.904540796040532,0.60848670285086,-0.519611744821519,-5.80902696550296,-0.214553341152524,"CTPS1","CTP synthase 1",TRUE
+"219080_s_at",0.625932126245264,0.0969436350259698,-1.73327436733986,-4.57363507408866,-0.692875503009434,"CTPS2","CTP synthase 2",TRUE
+"222819_at",0.720507507563255,0.196640863985869,-1.33125665730112,-5.11149290883676,-0.58774824174731,"CTPS2","CTP synthase 2",TRUE
+"202060_at",0.61760967235709,0.0881691777333108,-1.78374603808047,-4.49847978977075,-0.58154932392392,"CTR9","CTR9 homolog, Paf1/RNA polymerase II complex component",TRUE
+"214411_x_at",0.64971775198455,0.120223036064521,1.6161018420551,-4.74184052159428,0.778257509584964,"CTRB2","chymotrypsinogen B2",TRUE
+"205971_s_at",0.690139543208579,0.159776613405289,-1.45468936163772,-4.95842395162691,-0.769640873958428,"CTRB2///CTRB1","chymotrypsinogen B2///chymotrypsinogen B1",TRUE
+"206297_at",0.937632892550302,0.724072859506932,-0.35753729991481,-5.87761185419038,-0.155424478233131,"CTRC","chymotrypsin C",TRUE
+"214377_s_at",0.739508010556618,0.227542410983254,1.24111785675934,-5.21604333430992,0.678022546830365,"CTRL","chymotrypsin like",TRUE
+"200661_at",0.960506476261889,0.820570728764968,-0.229519470165291,-5.91405791327351,-0.117562396030017,"CTSA","cathepsin A",TRUE
+"227961_at",0.212348514754308,0.0025069174316589,3.40757274854428,-1.46585972657956,2.01991458531745,"CTSB","cathepsin B",TRUE
+"213274_s_at",0.227168192678334,0.00284578505618517,3.35451901243327,-1.57722095838536,1.46783754488565,"CTSB","cathepsin B",TRUE
+"213275_x_at",0.337201309610388,0.00836912989741741,2.89466783780927,-2.51953895108493,1.24395909435425,"CTSB","cathepsin B",TRUE
+"200838_at",0.539609110035715,0.0444541405488555,2.13069765671121,-3.9416021690932,1.06967398174788,"CTSB","cathepsin B",TRUE
+"200839_s_at",0.64513208805899,0.115910337500512,1.63626953522262,-4.71352884699411,0.806242827643176,"CTSB","cathepsin B",TRUE
+"225646_at",0.726636642789909,0.205979944881223,1.30292372662375,-5.14502633453378,1.55863957636033,"CTSC","cathepsin C",TRUE
+"225647_s_at",0.773107052530371,0.283918800999444,1.09817559891746,-5.36876447058699,1.07936352005567,"CTSC","cathepsin C",TRUE
+"201487_at",0.80008362094922,0.335548211757433,0.984397646012195,-5.47841032395131,0.819938577462933,"CTSC","cathepsin C",TRUE
+"231234_at",0.950368936943548,0.774513746544685,0.289998897824104,-5.89880459189637,0.282447506935059,"CTSC","cathepsin C",TRUE
+"200766_at",0.856874648266698,0.471497951894111,-0.732573480457992,-5.68162107467739,-0.570264152185457,"CTSD","cathepsin D",TRUE
+"205927_s_at",0.892780783477555,0.566092859229012,-0.582527730095865,-5.77574211790534,-0.200443091386617,"CTSE","cathepsin E",TRUE
+"203657_s_at",0.751464513744428,0.244462335623839,-1.19567849821157,-5.2663575613701,-0.969900697953527,"CTSF","cathepsin F",TRUE
+"205653_at",0.99186228645105,0.962445772035656,-0.0476199421018616,-5.93857904806904,-0.0232426511727324,"CTSG","cathepsin G",TRUE
+"202295_s_at",0.532405994061663,0.0419245282797871,2.15918828682972,-3.89299429467891,1.6918977573792,"CTSH","cathepsin H",TRUE
+"202450_s_at",0.916107385524794,0.646268117876265,0.465284967804848,-5.83478569809125,0.137603242280356,"CTSK","cathepsin K",TRUE
+"202087_s_at",0.8920930097751,0.562832934767024,0.58746217704645,-5.77297585339591,0.300145129348959,"CTSL","cathepsin L",TRUE
+"1563445_x_at",0.849646596450765,0.451109118397243,0.767117467052323,-5.65705577871643,0.314877708480921,"CTSLP8","cathepsin L pseudogene 8",TRUE
+"203758_at",0.69805586360447,0.169012092852866,-1.42178856844768,-5.00031676064264,-0.706386560927129,"CTSO","cathepsin O",TRUE
+"202901_x_at",0.527546822913581,0.0402387299271148,2.17905095066142,-3.85886834574779,2.39878950569899,"CTSS","cathepsin S",TRUE
+"202902_s_at",0.552986220491716,0.0504151275464098,2.0689397601711,-4.04555214744921,2.36564798021603,"CTSS","cathepsin S",TRUE
+"232617_at",0.590570903980459,0.0682688155101121,1.91665720660626,-4.2931744023775,0.855125606033541,"CTSS","cathepsin S",TRUE
+"210074_at",0.218630405352483,0.00266315226272984,3.3822950602793,-1.51897308215772,2.2055999182021,"CTSV","cathepsin V",TRUE
+"214450_at",0.971216837324271,0.862164028213445,-0.175650387655538,-5.92466725653535,-0.0642787023855123,"CTSW","cathepsin W",TRUE
+"210042_s_at",0.601886119917951,0.0770257548394943,1.85449970911558,-4.39049343105485,1.27023021321621,"CTSZ","cathepsin Z",TRUE
+"212562_s_at",0.866375885212743,0.497324319294046,0.690055429358322,-5.71037929948459,0.421582464901024,"CTSZ","cathepsin Z",TRUE
+"1567277_at",0.518874125067442,0.037287687343202,-2.21571186434954,-3.79537667255919,-1.15788403623227,"CTTN","cortactin",TRUE
+"214074_s_at",0.834265235157814,0.412384175786386,-0.835448146617908,-5.60532681406881,-0.436829316121253,"CTTN","cortactin",TRUE
+"214782_at",0.891249845423426,0.560517421756243,0.590976053324852,-5.7709922076082,0.55098067884303,"CTTN","cortactin",TRUE
+"201059_at",0.906507435035949,0.614563930243239,-0.510769879398769,-5.81340825502537,-0.286076287427626,"CTTN","cortactin",TRUE
+"214073_at",0.930820302962216,0.693274819383544,-0.399603165779421,-5.86220579569593,-0.281802493764051,"CTTN","cortactin",TRUE
+"232136_s_at",0.628076638668209,0.0994530905739705,-1.71956031795161,-4.59377988124999,-2.36632786910469,"CTTNBP2","cortactin binding protein 2",TRUE
+"226000_at",0.797508506396963,0.331007508077011,0.993889816433219,-5.46967714258664,0.548493253590358,"CTTNBP2NL","CTTNBP2 N-terminal like",TRUE
+"239525_at",0.868397087637799,0.504139684896552,-0.679047898775564,-5.71755720531037,-0.448334665215254,"CTTNBP2NL","CTTNBP2 N-terminal like",TRUE
+"231822_at",0.870433264908839,0.508814566502605,0.671545968360329,-5.7223858820192,0.339756598777134,"CTTNBP2NL","CTTNBP2 N-terminal like",TRUE
+"1561500_at",0.64513208805899,0.115962044719877,1.63602403371314,-4.71387510966421,1.05061577680106,"CTU2","cytosolic thiouridylase subunit 2",TRUE
+"1561501_s_at",0.76858139690485,0.271728987165716,1.12717256820129,-5.33911115190429,0.960831271119773,"CTU2","cytosolic thiouridylase subunit 2",TRUE
+"226410_at",0.900230636329568,0.594983708722548,-0.539409974346097,-5.79895115472013,-0.236811306323943,"CTU2","cytosolic thiouridylase subunit 2",TRUE
+"1561502_x_at",0.969882914559333,0.857093523029133,0.182185758742514,-5.92352997009687,0.0566874781572961,"CTU2","cytosolic thiouridylase subunit 2",TRUE
+"228126_x_at",0.772532966757283,0.28301576519754,-1.10029235919258,-5.3666230100956,-0.661630105526886,"CTXN1","cortexin 1",TRUE
+"232672_x_at",0.994145854504594,0.973170077517108,0.0340146060692533,-5.93911996762129,0.0172324519867439,"CTXN2///SLC24A5","cortexin 2///solute carrier family 24 member 5",TRUE
+"231391_at",0.667600335207197,0.133981333475574,1.55556251947459,-4.82518322051703,1.09972482212458,"CTXN3","cortexin 3",TRUE
+"236374_at",0.68680805784522,0.155352504636552,-1.47099669006763,-4.93737095543614,-0.831490554805643,"CTXN3","cortexin 3",TRUE
+"206775_at",0.959593724813212,0.817624751058954,0.233359457885074,-5.91319441304141,0.180839261597298,"CUBN","cubilin",TRUE
+"227667_at",0.907189812622248,0.616003358512335,-0.508681683761334,-5.81443228827836,-0.276289225926758,"CUEDC1","CUE domain containing 1",TRUE
+"219468_s_at",0.96479405380661,0.837135219246957,0.207991973885147,-5.91863474650522,0.218240190021369,"CUEDC1","CUE domain containing 1",TRUE
+"218097_s_at",0.979588787486838,0.901535374522882,-0.125147451714669,-5.93205803207929,-0.0443605207175732,"CUEDC2","CUE domain containing 2",TRUE
+"238509_at",0.374354475700726,0.0113658606248414,-2.76054255428535,-2.7844921751936,-0.932226721933163,"CUL1","cullin 1",TRUE
+"207614_s_at",0.748632141741128,0.241550524844832,-1.20332548306308,-5.25800402589503,-0.422457288735027,"CUL1","cullin 1",TRUE
+"203079_s_at",0.789860910391852,0.318854367887015,1.01974762558508,-5.44550143223368,0.245600528339091,"CUL2","cullin 2",TRUE
+"203078_at",0.854810562588402,0.466790523613281,-0.74046881625405,-5.67610100873275,-0.341724621010814,"CUL2","cullin 2",TRUE
+"201371_s_at",0.614341334173711,0.085249340692747,-1.80150144432859,-4.47166608131729,-0.457643487791321,"CUL3","cullin 3",TRUE
+"201370_s_at",0.764430688544079,0.264580230385277,-1.14462277083291,-5.32093686801987,-0.38473525654312,"CUL3","cullin 3",TRUE
+"201372_s_at",0.895690630367785,0.576318609126764,-0.567142841193695,-5.78422186694652,-0.491146266628651,"CUL3","cullin 3",TRUE
+"232466_at",0.425821574353662,0.0182867682959743,2.54772080934592,-3.19305143518347,1.28151608617466,"CUL4A","cullin 4A",TRUE
+"227757_at",0.505411134618713,0.0329949628508455,2.27405784315372,-3.69301280882371,1.56106691552629,"CUL4A","cullin 4A",TRUE
+"201424_s_at",0.695005304830231,0.164595146490989,1.43733815599191,-4.98061490606436,0.560318332985537,"CUL4A","cullin 4A",TRUE
+"201423_s_at",0.700963156261921,0.172640200582996,1.40925796821802,-5.01606544859352,0.584460062618547,"CUL4A","cullin 4A",TRUE
+"210257_x_at",0.761748280722165,0.261209180055802,1.15297213395562,-5.31215411078414,0.56458021804432,"CUL4B","cullin 4B",TRUE
+"202213_s_at",0.768852835478002,0.273538643314939,1.12280864883609,-5.34361759877869,0.541111973338554,"CUL4B","cullin 4B",TRUE
+"215997_s_at",0.769258076576208,0.276265617121864,1.11627231002808,-5.3503384765549,0.55204508073024,"CUL4B","cullin 4B",TRUE
+"202214_s_at",0.80110325033185,0.337798092488748,0.97972710613552,-5.4826794077318,0.454471453206473,"CUL4B","cullin 4B",TRUE
+"230393_at",0.800342373547779,0.336038031937707,-0.983378996185104,-5.47934299211487,-0.892257804680645,"CUL5","cullin 5",TRUE
+"203533_s_at",0.972899347107693,0.868698621465518,0.167239444522855,-5.92606997106038,0.087702301075872,"CUL5","cullin 5",TRUE
+"203532_x_at",0.984055193758035,0.921716162919421,0.0993979463632517,-5.93487246596955,0.0372097025755735,"CUL5","cullin 5",TRUE
+"203531_at",0.991689960875868,0.961542099337846,-0.0487667661141464,-5.93852521482401,-0.0157787932274509,"CUL5","cullin 5",TRUE
+"241747_s_at",0.866213023333941,0.497071771995277,0.690464959927985,-5.71011012100955,0.239677086194861,"CUL7","cullin 7",TRUE
+"203558_at",0.895457620469779,0.574482976493452,0.569894325472174,-5.78272146648613,0.346350706011902,"CUL7","cullin 7",TRUE
+"36084_at",0.934081042629428,0.708439268425196,-0.378803671207815,-5.87003435313624,-0.159649734941771,"CUL7","cullin 7",TRUE
+"241746_at",0.934949838990439,0.711074881659615,0.375206226969796,-5.87134652292949,0.180537333105672,"CUL7","cullin 7",TRUE
+"236392_at",0.646151618186642,0.117128645411025,1.63050939123284,-4.72164260020197,0.499116835820559,"CUL9","cullin 9",TRUE
+"213204_at",0.91671872326659,0.647701895230464,-0.463252042706834,-5.83569564157193,-0.198635203008523,"CUL9","cullin 9",TRUE
+"221488_s_at",0.937224988740666,0.721376117076789,0.361193432381429,-5.87633988264403,0.121081715849536,"CUTA","cutA divalent cation tolerance homolog",TRUE
+"218970_s_at",0.940567117317801,0.733820423042702,0.344362858125802,-5.88208919808024,0.128185314531336,"CUTC","cutC copper transporter",TRUE
+"227069_at",0.853460708803218,0.462058070091465,0.748453864369611,-5.6704611586543,0.281874659273093,"CUX1","cut like homeobox 1",TRUE
+"214743_at",0.858246094096012,0.473958332127915,0.728465409374759,-5.68447103352663,0.284494967938571,"CUX1","cut like homeobox 1",TRUE
+"202367_at",0.905462783815257,0.611703873035477,0.514925846886527,-5.81135803342209,0.274980169499248,"CUX1","cut like homeobox 1",TRUE
+"225935_at",0.917806614232276,0.651062259999928,0.458495182620399,-5.83780957397559,0.147754173945732,"CUX1","cut like homeobox 1",TRUE
+"225937_at",0.975398143273847,0.882439010946502,0.149593071322625,-5.92878981381852,0.0642708315652225,"CUX1","cut like homeobox 1",TRUE
+"1566528_at",0.618322986548619,0.0892354239143218,-1.77738843206703,-4.50803378589344,-0.755954201490857,"CUX2","cut like homeobox 2",TRUE
+"213920_at",0.8920930097751,0.564096031560724,0.585548525824493,-5.77405133123052,0.616250224419865,"CUX2","cut like homeobox 2",TRUE
+"220275_at",0.675447258877226,0.141701580900428,1.52381598623308,-4.8678853709783,0.636643092127436,"CUZD1","CUB and zona pellucida like domains 1",TRUE
+"223067_at",0.878032693702174,0.529838731839338,0.638272573121065,-5.74318239611681,0.24690531867498,"CWC15","CWC15 spliceosome-associated protein",TRUE
+"226588_at",0.572728296251991,0.0600952363024929,1.98135194162404,-4.18953339811182,0.630555646459042,"CWC22","CWC22 homolog, spliceosome-associated protein",TRUE
+"222706_at",0.856257656023992,0.469990704835334,-0.735096356390782,-5.67986329755262,-0.402791142101182,"CWC25","CWC25 spliceosome associated protein homolog",TRUE
+"218655_s_at",0.986342822130003,0.934403021239616,-0.083246559583544,-5.93630870187642,-0.0485245239550398,"CWC25","CWC25 spliceosome associated protein homolog",TRUE
+"1555495_a_at",0.809543749841217,0.352782676889456,-0.949150727427519,-5.51016944443022,-0.271277948130962,"CWC27","CWC27 spliceosome associated protein homolog",TRUE
+"223337_at",0.937113154905832,0.719485689664822,-0.363759387313743,-5.87543955349344,-0.112010067668679,"CWC27","CWC27 spliceosome associated protein homolog",TRUE
+"1558841_at",0.986482025143628,0.937315797095775,-0.0795417222927074,-5.93660235782566,-0.0320061680422139,"CWC27","CWC27 spliceosome associated protein homolog",TRUE
+"229038_at",0.790150670347509,0.319239658124855,1.01891740803059,-5.44628637600237,0.465964201265473,"CWF19L1","CWF19-like 1, cell cycle control (S. pombe)",TRUE
+"233568_x_at",0.909891927025433,0.624917270264875,0.495800601888786,-5.82065854354824,0.249810709258512,"CWF19L1","CWF19-like 1, cell cycle control (S. pombe)",TRUE
+"218787_x_at",0.954577684533304,0.792572098769044,0.266166611195692,-5.90523644332981,0.120129905451309,"CWF19L1","CWF19-like 1, cell cycle control (S. pombe)",TRUE
+"1566514_at",0.588653540532996,0.0672317688012226,1.9244747229391,-4.28077636608192,0.636826519544043,"CWF19L2","CWF19-like 2, cell cycle control (S. pombe)",TRUE
+"237040_at",0.682139937733475,0.149705559337822,1.49236813093717,-4.90949320754187,0.650140385735977,"CWF19L2","CWF19-like 2, cell cycle control (S. pombe)",TRUE
+"228916_at",0.731548533938014,0.215018430329609,1.27643722639384,-5.17582085543615,0.462098408862913,"CWF19L2","CWF19-like 2, cell cycle control (S. pombe)",TRUE
+"1566515_at",0.976371465776674,0.887301772998817,0.143359898987211,-5.92967828466294,0.123492802942273,"CWF19L2","CWF19-like 2, cell cycle control (S. pombe)",TRUE
+"220723_s_at",0.768852835478002,0.273777224590825,-1.12223489479195,-5.34420894185606,-1.1086134508148,"CWH43","cell wall biogenesis 43 C-terminal homolog",TRUE
+"220724_at",0.916107385524794,0.646113431125412,-0.465504413989148,-5.83468723996205,-0.471316998292747,"CWH43","cell wall biogenesis 43 C-terminal homolog",TRUE
+"203687_at",0.832741974897873,0.409539990178855,-0.840622173881548,-5.60124155404475,-0.962790161289516,"CX3CL1","C-X3-C motif chemokine ligand 1",TRUE
+"823_at",0.992031007642741,0.963127388160804,-0.0467549668343072,-5.93861880372098,-0.0412044542072145,"CX3CL1","C-X3-C motif chemokine ligand 1",TRUE
+"205898_at",0.882393067754682,0.53994224919617,0.622539050120053,-5.75266244745356,0.631949472544543,"CX3CR1","C-X3-C motif chemokine receptor 1",TRUE
+"1568934_at",0.914242258486146,0.639265037045643,-0.475243362779754,-5.83027193924251,-0.302387589596284,"CX3CR1","C-X3-C motif chemokine receptor 1",TRUE
+"1555716_a_at",0.640067422642767,0.110509498092755,1.66243457091127,-4.67639706229339,1.61567715312313,"CXADR","coxsackie virus and adenovirus receptor",TRUE
+"203917_at",0.680708651141727,0.14843450633408,1.49726885702888,-4.90305491038875,1.94650515476006,"CXADR","coxsackie virus and adenovirus receptor",TRUE
+"226374_at",0.744573608322482,0.235898150254343,1.2183700920782,-5.24143452196184,1.60638316689848,"CXADR","coxsackie virus and adenovirus receptor",TRUE
+"239155_at",0.757950630724418,0.254589991478481,1.16960116771487,-5.29449503724296,1.03845330209485,"CXADR","coxsackie virus and adenovirus receptor",TRUE
+"204470_at",0.171054203824867,0.00146262158644814,3.6314162850124,-0.991727398856266,4.83061725405005,"CXCL1","C-X-C motif chemokine ligand 1",TRUE
+"204533_at",0.73759219552868,0.224317750042076,1.25006676307625,-5.20594368678811,1.18504549792049,"CXCL10","C-X-C motif chemokine ligand 10",TRUE
+"210163_at",0.250786685520724,0.0035456444061732,3.26209322912633,-1.77011469430476,3.96299656543621,"CXCL11","C-X-C motif chemokine ligand 11",TRUE
+"211122_s_at",0.304824368772306,0.0059220614652015,3.04404004982685,-2.21864015729558,3.60990494537244,"CXCL11","C-X-C motif chemokine ligand 11",TRUE
+"203666_at",0.697713925841949,0.168555550439414,-1.4233805756055,-4.9983077018366,-1.12105182465694,"CXCL12","C-X-C motif chemokine ligand 12",TRUE
+"209687_at",0.789503009592599,0.316541746814205,-1.02474564436557,-5.44076376076942,-1.86918955802053,"CXCL12","C-X-C motif chemokine ligand 12",TRUE
+"205242_at",0.878788356961452,0.53216184540936,0.634640704403418,-5.74539094423837,0.517760055685721,"CXCL13","C-X-C motif chemokine ligand 13",TRUE
+"222484_s_at",0.827985973549523,0.39749454058245,-0.862792645540909,-5.58347012082076,-1.74569249838646,"CXCL14","C-X-C motif chemokine ligand 14",TRUE
+"237038_at",0.936992192746977,0.718258383516006,0.365426592475941,-5.87485120060974,0.321012288084585,"CXCL14","C-X-C motif chemokine ligand 14",TRUE
+"218002_s_at",0.996261754016157,0.982007125304659,0.0228085889964767,-5.93943009822982,0.0454689903738963,"CXCL14","C-X-C motif chemokine ligand 14",TRUE
+"223454_at",0.322131160460075,0.00724863370871895,2.95700557516893,-2.3946632401839,2.42588710640726,"CXCL16","C-X-C motif chemokine ligand 16",TRUE
+"226960_at",0.936599157163462,0.7169284267889,-0.367234433137702,-5.87421021639699,-0.423313290923636,"CXCL17","C-X-C motif chemokine ligand 17",TRUE
+"209774_x_at",0.406049718268978,0.0152308446377459,2.63025609325202,-3.03646787335266,3.2847452069271,"CXCL2","C-X-C motif chemokine ligand 2",TRUE
+"1569203_at",0.831875452294783,0.407023696792431,0.845218789000408,-5.59759244682009,0.576270155765854,"CXCL2","C-X-C motif chemokine ligand 2",TRUE
+"230101_at",0.910165867297668,0.626412629739212,0.49364808991635,-5.82168378748206,0.176778832689648,"CXCL2","C-X-C motif chemokine ligand 2",TRUE
+"207850_at",0.588370213314505,0.0670244557270347,1.9260502015296,-4.27827354179756,1.8683373074383,"CXCL3","C-X-C motif chemokine ligand 3",TRUE
+"214974_x_at",0.271686396298414,0.00429331589212308,3.1811873535669,-1.93768563312485,4.05569303040736,"CXCL5","C-X-C motif chemokine ligand 5",TRUE
+"215101_s_at",0.321503515621139,0.00714357226332189,2.9633160735406,-2.38196463648118,4.11749356536617,"CXCL5","C-X-C motif chemokine ligand 5",TRUE
+"207852_at",0.919354071504066,0.656683067342596,0.450562365302078,-5.84128732117912,0.478816688763712,"CXCL5","C-X-C motif chemokine ligand 5",TRUE
+"206336_at",0.189644672791897,0.00192106495093435,3.51845156220827,-1.23179412569447,3.27819194525169,"CXCL6","C-X-C motif chemokine ligand 6",TRUE
+"211506_s_at",0.364513221153898,0.0106737204767698,2.78824082008575,-2.73021636390446,4.01672941264627,"CXCL8","C-X-C motif chemokine ligand 8",TRUE
+"202859_x_at",0.384135218769668,0.0123829848926865,2.72261087599025,-2.85842943384825,3.90785719319927,"CXCL8","C-X-C motif chemokine ligand 8",TRUE
+"203915_at",0.729083413548563,0.211224165900489,1.28744912375313,-5.16308319874259,0.480299609853915,"CXCL9","C-X-C motif chemokine ligand 9",TRUE
+"207094_at",0.881970070870254,0.539231611381699,-0.623640473154659,-5.75200621254548,-0.341300664814626,"CXCR1","C-X-C motif chemokine receptor 1",TRUE
+"207008_at",0.812302873476553,0.360145119373955,0.934449436611256,-5.52310252623396,0.668815123045793,"CXCR2","C-X-C motif chemokine receptor 2",TRUE
+"217119_s_at",0.83364851657447,0.41121293668111,0.837576066089178,-5.60364952419295,0.45733034960734,"CXCR3","C-X-C motif chemokine receptor 3",TRUE
+"207681_at",0.894272567245808,0.570673527568719,0.575618666247639,-5.77957740522209,0.319417534227756,"CXCR3","C-X-C motif chemokine receptor 3",TRUE
+"209201_x_at",0.522016286799917,0.0380281823561787,-2.20627156053771,-3.81178793577108,-2.56287826031922,"CXCR4","C-X-C motif chemokine receptor 4",TRUE
+"211919_s_at",0.565956563686213,0.0568145683735958,-2.00953091336095,-4.14366313958293,-1.3413480388471,"CXCR4","C-X-C motif chemokine receptor 4",TRUE
+"217028_at",0.690823350461169,0.160473912796674,-1.45215252880511,-4.96168190983014,-2.16736020907176,"CXCR4","C-X-C motif chemokine receptor 4",TRUE
+"206126_at",0.82881747286857,0.399373864766304,0.859305527383394,-5.58629388987141,0.373597723767897,"CXCR5","C-X-C motif chemokine receptor 5",TRUE
+"216734_s_at",0.933938389322633,0.707357868658592,-0.380281184423052,-5.86949185190006,-0.149803962015522,"CXCR5","C-X-C motif chemokine receptor 5",TRUE
+"206974_at",0.914092998113138,0.638970650112227,0.475663044383655,-5.83007965947955,0.271199108007719,"CXCR6","C-X-C motif chemokine receptor 6",TRUE
+"211469_s_at",0.952082954955992,0.780745784613307,0.281755559433787,-5.90109118988042,0.202449091828068,"CXCR6","C-X-C motif chemokine receptor 6",TRUE
+"220252_x_at",0.967064564853331,0.846046626989106,0.196452674572276,-5.92090339818059,0.0828983902554725,"CXorf21","chromosome X open reading frame 21",TRUE
+"232087_at",0.737123149977386,0.222978145645047,-1.2538132530674,-5.20169692985624,-0.434099887976656,"CXorf23","chromosome X open reading frame 23",TRUE
+"222911_s_at",0.506052373093096,0.0331342228311695,2.27205901403814,-3.69654581339616,1.25191532854666,"CXorf36","chromosome X open reading frame 36",TRUE
+"1553584_at",0.625114087834963,0.0963939071703077,-1.73631902295875,-4.56914658660177,-0.833963178868087,"CXorf36","chromosome X open reading frame 36",TRUE
+"219652_s_at",0.76535523021157,0.265561117006743,1.14220806465943,-5.32346644171237,0.394304785041321,"CXorf36","chromosome X open reading frame 36",TRUE
+"241381_at",0.841247691968787,0.431299176857922,-0.801597483644627,-5.63147121767024,-0.621464107692296,"CXorf36","chromosome X open reading frame 36",TRUE
+"230532_at",0.7768734672127,0.295064221819024,-1.07244150658576,-5.39450476071976,-0.321715803043601,"CXorf38","chromosome X open reading frame 38",TRUE
+"228700_at",0.783215903203604,0.305695329111623,-1.04853577742833,-5.41792669778509,-0.3791052398327,"CXorf38","chromosome X open reading frame 38",TRUE
+"213315_x_at",0.270526247124227,0.0042304516011196,-3.187441542129,-1.92477777282044,-1.21748059831278,"CXorf40A","chromosome X open reading frame 40A",TRUE
+"212961_x_at",0.299994279961527,0.00558851773392353,-3.06887577712722,-2.16807427806096,-1.18134633242085,"CXorf40B","chromosome X open reading frame 40B",TRUE
+"214112_s_at",0.224460431387891,0.00276035948177395,-3.36728788421909,-1.55045918769096,-1.30648131853761,"CXorf40B///CXorf40A","chromosome X open reading frame 40B///chromosome X open reading frame 40A",TRUE
+"228809_at",0.585036027492332,0.0652051212494285,-1.94006327979383,-4.25595010412494,-0.675533469147197,"CXorf40B///CXorf40A","chromosome X open reading frame 40B///chromosome X open reading frame 40A",TRUE
+"231159_at",0.991741696110419,0.961667480616115,-0.0486076445122574,-5.93853276069929,-0.0269502582476386,"CXorf51B///CXorf51A","chromosome X open reading frame 51B///chromosome X open reading frame 51A",TRUE
+"235442_at",0.864894115958506,0.493251973778263,-0.696673673463601,-5.70601054891987,-0.448191767132498,"CXorf56","chromosome X open reading frame 56",TRUE
+"219805_at",0.921727601757524,0.66602861209883,-0.437437123931369,-5.84691066952366,-0.157324096454699,"CXorf56","chromosome X open reading frame 56",TRUE
+"219355_at",0.6642007803758,0.132281340603787,1.56275517774512,-4.81541180734248,2.31464165561353,"CXorf57","chromosome X open reading frame 57",TRUE
+"215803_at",0.957289701021675,0.806627679988662,-0.247726039466272,-5.9098374218836,-0.258339779087119,"CXorf57","chromosome X open reading frame 57",TRUE
+"1553391_at",0.89961817630669,0.590562456608684,-0.545939764846192,-5.79554764008006,-0.534024985093887,"CXorf58","chromosome X open reading frame 58",TRUE
+"231377_at",0.922220473850152,0.668114366149145,-0.434518519661716,-5.848138934251,-0.166216704700902,"CXorf65","chromosome X open reading frame 65",TRUE
+"1555396_s_at",0.914588178928864,0.640434709473597,0.473576717853062,-5.83103388377128,0.175780081089377,"CXorf67","chromosome X open reading frame 67",TRUE
+"218058_at",0.535243600695458,0.0427980605965589,-2.14917851812863,-3.91011814738351,-0.764715148525031,"CXXC1","CXXC finger protein 1",TRUE
+"48580_at",0.714148064967406,0.189211684848978,-1.35455709250703,-5.08346152593618,-0.360244442253569,"CXXC1","CXXC finger protein 1",TRUE
+"1564367_at",0.919354071504066,0.656469333061135,0.450863475371269,-5.84115640103713,0.162240502780223,"CXXC1P1","CXXC finger protein 1 pseudogene 1",TRUE
+"220277_at",0.984161165881616,0.922799217438857,0.0980181353932103,-5.93500507816259,0.0998783288604281,"CXXC4","CXXC finger protein 4",TRUE
+"229774_at",0.989586772349659,0.949576723713593,0.0639585964179342,-5.93769124699724,0.0557436600931203,"CXXC4","CXXC finger protein 4",TRUE
+"224516_s_at",0.559167054471987,0.052906906280325,-2.0450484853792,-4.0852335901706,-1.45925370304422,"CXXC5","CXXC finger protein 5",TRUE
+"233955_x_at",0.592488489935347,0.0695656844406991,-1.90702654455537,-4.30839981532282,-1.31511518751558,"CXXC5","CXXC finger protein 5",TRUE
+"222996_s_at",0.62179111032845,0.0921792049450426,-1.76016900703546,-4.53378498666046,-1.32035123370377,"CXXC5","CXXC finger protein 5",TRUE
+"216846_at",0.991689960875868,0.961209346809663,-0.0491890692036463,-5.9385050687876,-0.0154666366539735,"CYAT1","immunoglobulin lambda light chain-like",TRUE
+"1558176_at",0.965066122135834,0.837679159109692,-0.207286818950174,-5.91877708025464,-0.147103454735454,"CYAT1///IGLV1-44///IGLC1","immunoglobulin lambda light chain-like///immunoglobulin lambda variable 1-44///immunoglobulin lambda constant 1",TRUE
+"215121_x_at",0.973071267819624,0.870666896755518,-0.164708443080156,-5.92647863961634,-0.0873541966645925,"CYAT1///IGLV1-44///IGLC1","immunoglobulin lambda light chain-like///immunoglobulin lambda variable 1-44///immunoglobulin lambda constant 1",TRUE
+"1565495_at",0.990605394412423,0.952297997901909,-0.0605023090406333,-5.93790072910606,-0.0313911034011571,"CYAT1///IGLV1-44///IGLC1","immunoglobulin lambda light chain-like///immunoglobulin lambda variable 1-44///immunoglobulin lambda constant 1",TRUE
+"209163_at",0.851733415458562,0.456652049134231,-0.757635374406848,-5.66390544790079,-0.425070090570586,"CYB561","cytochrome b561",TRUE
+"210816_s_at",0.897949253801113,0.586201901573719,-0.552403509660732,-5.79213936734673,-0.288048681625797,"CYB561","cytochrome b561",TRUE
+"217200_x_at",0.920780424288498,0.66307009676376,-0.441583626457387,-5.84515177751978,-0.203832883473197,"CYB561","cytochrome b561",TRUE
+"209164_s_at",0.942961933269639,0.744189267438715,-0.330416532891763,-5.88664776977418,-0.173280801257082,"CYB561","cytochrome b561",TRUE
+"207986_x_at",0.972651966697198,0.867692723834583,-0.168533357217368,-5.92585864839262,-0.118250051614844,"CYB561","cytochrome b561",TRUE
+"224735_at",0.544577979658206,0.0466373317571224,-2.10726043649679,-3.9812818759486,-0.721689284913444,"CYB561A3","cytochrome b561 family member A3",TRUE
+"227981_at",0.872670205591254,0.516829512211472,-0.65877330687484,-5.73048888880777,-0.294436592550005,"CYB561D1","cytochrome b561 family member D1",TRUE
+"209665_at",0.835952408568777,0.416188086341579,-0.82856343604429,-5.61072621297289,-0.50455996746925,"CYB561D2","cytochrome b561 family member D2",TRUE
+"229636_at",0.989654520357877,0.950120870984678,-0.0632674130787812,-5.93773406927075,-0.0581609354786892,"CYB561D2","cytochrome b561 family member D2",TRUE
+"209366_x_at",0.405141741421442,0.0151247858982034,-2.63339181352194,-3.03047071435153,-1.29484647693865,"CYB5A","cytochrome b5 type A",TRUE
+"207843_x_at",0.432151440378733,0.0193175600476359,-2.52278087824556,-3.23987162165948,-1.16620299316296,"CYB5A","cytochrome b5 type A",TRUE
+"215726_s_at",0.43607430599822,0.0198915284711396,-2.50942723485132,-3.26484313631053,-1.08633614258315,"CYB5A","cytochrome b5 type A",TRUE
+"217021_at",0.759462911207093,0.257016060072222,-1.16346947628887,-5.30103234385927,-0.900019220719634,"CYB5A","cytochrome b5 type A",TRUE
+"238554_at",0.522042520786155,0.0380587377751004,-2.20588561996154,-3.81245795572606,-1.0197969768204,"CYB5B","cytochrome b5 type B",TRUE
+"227382_at",0.847880760418453,0.447535269591516,-0.773268514542492,-5.65256935615248,-0.269422117180122,"CYB5B","cytochrome b5 type B",TRUE
+"201633_s_at",0.9286288141895,0.686295480774943,0.409236050291872,-5.85844056559745,0.118023400875689,"CYB5B","cytochrome b5 type B",TRUE
+"201634_s_at",0.972022150098794,0.865859233524947,0.170892583760627,-5.92546915745258,0.0671940794895214,"CYB5B","cytochrome b5 type B",TRUE
+"1552711_a_at",0.92365974445982,0.672113450998335,-0.428933267020921,-5.85046691717027,-0.232343868656036,"CYB5D1","cytochrome b5 domain containing 1",TRUE
+"226833_at",0.954506242294505,0.791529261054352,-0.267538473008288,-5.90488105056319,-0.100048361566767,"CYB5D1","cytochrome b5 domain containing 1",TRUE
+"225804_at",0.971242929121865,0.863504067480354,0.17392453102649,-5.92496067749275,0.0535025662697013,"CYB5D2","cytochrome b5 domain containing 2",TRUE
+"202263_at",0.683970477958028,0.152971058528873,-1.47993119925947,-4.92575587985628,-0.669558866419882,"CYB5R1","cytochrome b5 reductase 1",TRUE
+"1560043_at",0.966593471043185,0.844710638327844,0.198180856833529,-5.92057184404346,0.0933776687034102,"CYB5R1","cytochrome b5 reductase 1",TRUE
+"220230_s_at",0.780429362666663,0.301951581853692,1.05688566709626,-5.40979960073162,1.15191474212818,"CYB5R2","cytochrome b5 reductase 2",TRUE
+"1554574_a_at",0.910327933615304,0.627291285796873,0.492384401200511,-5.82228365404906,0.19156959063859,"CYB5R3","cytochrome b5 reductase 3",TRUE
+"201885_s_at",0.974670398319743,0.876285287605035,0.157489760874667,-5.92761005755051,0.056852419961146,"CYB5R3","cytochrome b5 reductase 3",TRUE
+"219079_at",0.508488499910913,0.0335984755566331,2.26545051170351,-3.70821350183417,0.744823396471073,"CYB5R4","cytochrome b5 reductase 4",TRUE
+"240020_at",0.647518308302168,0.118460348310661,1.62427033069178,-4.73040610265417,1.00162171843522,"CYB5R4","cytochrome b5 reductase 4",TRUE
+"235991_at",0.717354643280305,0.193095557144357,-1.3422881068127,-5.09827245659253,-0.847908837379872,"CYB5RL","cytochrome b5 reductase like",TRUE
+"229605_at",0.822862741321714,0.388660102441696,-0.879329446624967,-5.56993439330714,-0.821601459272231,"CYB5RL","cytochrome b5 reductase like",TRUE
+"235992_s_at",0.929088231432081,0.687731530290994,-0.407250823357879,-5.85922375751409,-0.106845819230168,"CYB5RL","cytochrome b5 reductase like",TRUE
+"238280_at",0.974982245454858,0.878298202868417,-0.154905608693693,-5.92800279060106,-0.104613314070902,"CYB5RL","cytochrome b5 reductase like",TRUE
+"203028_s_at",0.765278605568716,0.265520533107243,1.14230784208851,-5.32336201105667,1.98417924808576,"CYBA","cytochrome b-245 alpha chain",TRUE
+"229445_at",0.943294768503521,0.745234627257816,-0.329014248791641,-5.88709581316381,-0.260083065867251,"CYBA","cytochrome b-245 alpha chain",TRUE
+"233538_s_at",0.631011867940957,0.102139095222267,1.7052044756376,-4.61473930366785,1.18903485218206,"CYBB","cytochrome b-245 beta chain",TRUE
+"203923_s_at",0.757850812302788,0.25393635994787,1.17126058896721,-5.29272067171951,0.564919969166566,"CYBB","cytochrome b-245 beta chain",TRUE
+"217431_x_at",0.900867933475689,0.596904300430248,0.536580825190218,-5.80041342551993,0.41499238059684,"CYBB","cytochrome b-245 beta chain",TRUE
+"203922_s_at",0.971576577583621,0.864529896223516,0.172603716404062,-5.92518328394618,0.0540281287778317,"CYBB","cytochrome b-245 beta chain",TRUE
+"222453_at",0.729083413548563,0.210795159743695,1.28870379176587,-5.16162599193579,2.10374525023787,"CYBRD1","cytochrome b reductase 1",TRUE
+"217889_s_at",0.784552021081681,0.308275031328684,1.04282422451479,-5.42345248188733,2.11816694051294,"CYBRD1","cytochrome b reductase 1",TRUE
+"201066_at",0.986889306520757,0.939363336628021,0.0769380879109434,-5.93680073669331,0.0336391480099287,"CYC1","cytochrome c1",TRUE
+"208905_at",0.878278790222455,0.530939880586881,-0.636550004177394,-5.74423140530818,-0.144455965137698,"CYCS","cytochrome c, somatic",TRUE
+"244546_at",0.991059530537351,0.958070831499299,0.053172685603531,-5.93830648418261,0.0305293826167947,"CYCS","cytochrome c, somatic",TRUE
+"229415_at",0.993474831312851,0.969261466548105,0.038972345016884,-5.93894373507034,0.0185279330640302,"CYCS","cytochrome c, somatic",TRUE
+"208923_at",0.615964925929095,0.0871018063044036,1.79017704018665,-4.48879018963647,0.656204426514003,"CYFIP1","cytoplasmic FMR1 interacting protein 1",TRUE
+"220999_s_at",0.336826888144502,0.00835367645768532,-2.89547188451946,-2.517934972787,-3.34031755830692,"CYFIP2","cytoplasmic FMR1 interacting protein 2",TRUE
+"215785_s_at",0.345235484905341,0.00876964077332056,-2.87430881737288,-2.5600928686304,-3.33637420982525,"CYFIP2","cytoplasmic FMR1 interacting protein 2",TRUE
+"1553572_a_at",0.250356179889913,0.00350668086384713,3.26675146828177,-1.76042885808037,2.27011258068191,"CYGB","cytoglobin",TRUE
+"226632_at",0.623503825356688,0.0942386559982433,1.74840093461015,-4.55127768044582,1.53300355050172,"CYGB","cytoglobin",TRUE
+"1570410_at",0.806089660856733,0.346492739372572,0.961875616974574,-5.49882575914391,0.272300931899071,"CYGB","cytoglobin",TRUE
+"229945_at",0.748760747870936,0.241831189892089,1.20258539437813,-5.25881451840214,0.343113483287384,"CYHR1","cysteine and histidine rich 1",TRUE
+"223421_at",0.784552021081681,0.308297077898976,-1.04277555862118,-5.42349944826784,-0.633828331959561,"CYHR1","cysteine and histidine rich 1",TRUE
+"213072_at",0.789927874973432,0.319105592388566,1.01920621128474,-5.44601338745267,0.519122235924096,"CYHR1","cysteine and histidine rich 1",TRUE
+"213681_at",0.862800800218883,0.48675728218065,-0.707293759356019,-5.69891704361274,-0.223369171240581,"CYHR1","cysteine and histidine rich 1",TRUE
+"216809_at",0.740668810029442,0.230831299898395,1.23208966551116,-5.22616915219087,0.366083246870949,"CYLC1","cylicin 1",TRUE
+"216778_s_at",0.769258076576208,0.276515629246914,-1.11567540944113,-5.35095049763664,-0.812998563914783,"CYLC1","cylicin 1",TRUE
+"216779_at",0.84124805634277,0.431483084317654,0.801272954911708,-5.63171695532573,0.521294009747542,"CYLC1","cylicin 1",TRUE
+"207780_at",0.731054546207485,0.213745086405935,1.28011595691396,-5.17157597300494,0.349584063667625,"CYLC2","cylicin 2",TRUE
+"221905_at",0.73936001229895,0.226997316798034,-1.24262375131729,-5.21434816319702,-0.895367943873468,"CYLD","CYLD lysine 63 deubiquitinase",TRUE
+"213295_at",0.793016712530949,0.32486888314901,-1.00686665823826,-5.45761480788013,-0.506229761332782,"CYLD","CYLD lysine 63 deubiquitinase",TRUE
+"214272_at",0.797041381178845,0.330044808868194,0.995913839896544,-5.46780510675726,0.303148595063472,"CYLD","CYLD lysine 63 deubiquitinase",TRUE
+"60084_at",0.868245365203247,0.502335722679,0.681953245806431,-5.71567337313542,0.286906024433321,"CYLD","CYLD lysine 63 deubiquitinase",TRUE
+"39582_at",0.898861791800173,0.588851059144007,-0.548473787670407,-5.79421611689521,-0.354318579576749,"CYLD","CYLD lysine 63 deubiquitinase",TRUE
+"222142_at",0.913299709879835,0.636309495129266,-0.479460766844976,-5.82833216010631,-0.304361229478934,"CYLD","CYLD lysine 63 deubiquitinase",TRUE
+"221903_s_at",0.998870448604467,0.996041614164712,0.00501739784325962,-5.93967121929237,0.00419995215715829,"CYLD","CYLD lysine 63 deubiquitinase",TRUE
+"242902_at",0.982329043274333,0.914918004035828,-0.108063425883694,-5.93399730180741,-0.0685259248043337,"CYMP","chymosin pseudogene",TRUE
+"204309_at",0.552420073963858,0.050286140066175,2.07020503834723,-4.04344224653594,1.88592537168312,"CYP11A1","cytochrome P450 family 11 subfamily A member 1",TRUE
+"214610_at",0.7083523771159,0.180343211512635,1.38333535318694,-5.0482801570356,0.851317042933277,"CYP11B1","cytochrome P450 family 11 subfamily B member 1",TRUE
+"1552493_s_at",0.910165867297668,0.626475475951541,0.493557677054896,-5.82172675588765,0.188461018863782,"CYP11B1","cytochrome P450 family 11 subfamily B member 1",TRUE
+"214630_at",0.961212424803935,0.823658753332544,0.225498112376035,-5.91494691739945,0.130388525709051,"CYP11B2","cytochrome P450 family 11 subfamily B member 2",TRUE
+"1562573_at",0.76711764189372,0.26890838805805,-1.13401695986339,-5.3320121179798,-0.949956502060142,"CYP17A1","cytochrome P450 family 17 subfamily A member 1",TRUE
+"205502_at",0.812302873476553,0.356760393060731,0.941182654689966,-5.51720214479879,0.442033033237188,"CYP17A1","cytochrome P450 family 17 subfamily A member 1",TRUE
+"240863_at",0.603702127972549,0.0781132961214095,1.84721678285945,-4.40174778380429,1.6983168526379,"CYP19A1","cytochrome P450 family 19 subfamily A member 1",TRUE
+"240705_at",0.678126513742682,0.145415765566775,1.50904685573068,-4.88751245081166,1.2071731760366,"CYP19A1","cytochrome P450 family 19 subfamily A member 1",TRUE
+"1560295_at",0.816800680706682,0.368405229690147,0.918193730051025,-5.53718694526688,0.253864767851409,"CYP19A1","cytochrome P450 family 19 subfamily A member 1",TRUE
+"239459_s_at",0.896115372949367,0.577555447696328,0.565291399505527,-5.78522750679531,0.405653086335403,"CYP19A1","cytochrome P450 family 19 subfamily A member 1",TRUE
+"239460_at",0.90998880119877,0.625263655357037,-0.495301782995494,-5.82089651936647,-0.35965875548377,"CYP19A1","cytochrome P450 family 19 subfamily A member 1",TRUE
+"1554296_at",0.974884920935236,0.876873362465128,0.156734685945239,-5.92772548227287,0.164135167075882,"CYP19A1","cytochrome P450 family 19 subfamily A member 1",TRUE
+"203475_at",0.9882620262439,0.944135868999155,0.0708714580101124,-5.93723737388849,0.0466687896971392,"CYP19A1","cytochrome P450 family 19 subfamily A member 1",TRUE
+"205749_at",0.955515814503015,0.796066854476551,0.261573016491758,-5.90641324207222,0.271397659220264,"CYP1A1","cytochrome P450 family 1 subfamily A member 1",TRUE
+"207608_x_at",0.929829824527542,0.690356786156517,0.403625903834622,-5.86064415348788,0.131871264156516,"CYP1A2","cytochrome P450 family 1 subfamily A member 2",TRUE
+"207609_s_at",0.998347572104896,0.992494368866379,0.00951376839547963,-5.93963939588992,0.00675306371242401,"CYP1A2","cytochrome P450 family 1 subfamily A member 2",TRUE
+"202435_s_at",0.813065886130395,0.362612402676467,0.929568003903979,-5.52735582918702,0.95435513589084,"CYP1B1","cytochrome P450 family 1 subfamily B member 1",TRUE
+"202434_s_at",0.813065886130395,0.362861924362665,0.929075574206821,-5.52778375697438,1.02479274943096,"CYP1B1","cytochrome P450 family 1 subfamily B member 1",TRUE
+"202436_s_at",0.831370271469237,0.405563319460098,0.847894829247048,-5.59545947131159,0.838370364230142,"CYP1B1","cytochrome P450 family 1 subfamily B member 1",TRUE
+"202437_s_at",0.902424542997102,0.601319539052346,0.530093624745775,-5.8037381499036,0.615533848259405,"CYP1B1","cytochrome P450 family 1 subfamily B member 1",TRUE
+"1553829_at",0.771527793162888,0.280715204123803,1.10570718887811,-5.36112831963456,0.804718199798832,"CYP1B1-AS1","CYP1B1 antisense RNA 1",TRUE
+"233410_at",0.831487912516861,0.40593656989945,-0.84721028946727,-5.59600569208701,-0.391938944904317,"CYP1B1-AS1","CYP1B1 antisense RNA 1",TRUE
+"219565_at",0.643515428391208,0.114064221873372,-1.64509562290617,-4.70105379809081,-0.775102309243938,"CYP20A1","cytochrome P450 family 20 subfamily A member 1",TRUE
+"214622_at",0.380084968057051,0.0118326399109551,2.74275195909578,-2.81922708427959,1.09261103181037,"CYP21A1P///CYP21A2","cytochrome P450 family 21 subfamily A member 1, pseudogene///cytochrome P450 family 21 subfamily A member 2",TRUE
+"206504_at",0.228900728752571,0.00289260022823908,3.34767894326984,-1.59154594255392,2.58675549031157,"CYP24A1","cytochrome P450 family 24 subfamily A member 1",TRUE
+"206424_at",0.713633547141264,0.188591066849867,1.3565359244019,-5.08106215537266,1.34192170973985,"CYP26A1","cytochrome P450 family 26 subfamily A member 1",TRUE
+"234721_s_at",0.740557886075316,0.229813363567259,1.23487344903957,-5.22305371570646,0.532027230958472,"CYP26B1","cytochrome P450 family 26 subfamily B member 1",TRUE
+"219825_at",0.820536502908875,0.379879279339874,-0.896010108605825,-5.55603953383992,-1.32171208393293,"CYP26B1","cytochrome P450 family 26 subfamily B member 1",TRUE
+"203979_at",0.598790786356002,0.0756937717447482,1.86354258653695,-4.37647567108143,1.22165977948973,"CYP27A1","cytochrome P450 family 27 subfamily A member 1",TRUE
+"205676_at",0.844473820002796,0.441273288294099,0.784118633108128,-5.64457315994594,0.474817366804755,"CYP27B1","cytochrome P450 family 27 subfamily B member 1",TRUE
+"1568868_at",0.300851187527495,0.00572531120054754,3.0585219054816,-2.18917242531368,2.3704104349244,"CYP27C1","cytochrome P450 family 27 subfamily C member 1",TRUE
+"208327_at",0.731548533938014,0.215183942812229,-1.27596028919234,-5.17637042967421,-0.915947453933544,"CYP2A13","cytochrome P450 family 2 subfamily A member 13",TRUE
+"211295_x_at",0.671164788615943,0.137019503804868,1.54289373678443,-4.84230755788426,0.696282521646788,"CYP2A6","cytochrome P450 family 2 subfamily A member 6",TRUE
+"214320_x_at",0.909441642299191,0.624019899658517,0.497093472399157,-5.82004065386495,0.27155903623237,"CYP2A6","cytochrome P450 family 2 subfamily A member 6",TRUE
+"1494_f_at",0.962351204352784,0.828561069392406,0.219121879050157,-5.91632445920764,0.069743478844229,"CYP2A6","cytochrome P450 family 2 subfamily A member 6",TRUE
+"207244_x_at",0.99783553534859,0.989808649648951,0.012918225652943,-5.93960219971092,0.0100190909292071,"CYP2A6","cytochrome P450 family 2 subfamily A member 6",TRUE
+"207718_x_at",0.737135512363148,0.2232176172769,1.25314225885397,-5.20245832332765,0.634944170152893,"CYP2A7","cytochrome P450 family 2 subfamily A member 7",TRUE
+"216334_s_at",0.889452275006221,0.557471524539686,0.595609785035556,-5.76835890075728,0.468209964847569,"CYP2A7P1","cytochrome P450 family 2 subfamily A member 7 pseudogene 1",TRUE
+"216340_s_at",0.918141489589102,0.652335760200241,-0.456695251954008,-5.83860388153985,-0.19616790006911,"CYP2A7P1","cytochrome P450 family 2 subfamily A member 7 pseudogene 1",TRUE
+"206755_at",0.639705117673934,0.110214808042883,1.66389299882228,-4.67431412856182,1.26773121103948,"CYP2B6","cytochrome P450 family 2 subfamily B member 6",TRUE
+"217133_x_at",0.974536463688956,0.875321554699314,-0.158727375233919,-5.92741967243768,-0.112018539475078,"CYP2B6","cytochrome P450 family 2 subfamily B member 6",TRUE
+"210272_at",0.784498961298069,0.307679519507956,-1.04413969731411,-5.42218220104699,-1.27353586274119,"CYP2B7P","cytochrome P450 family 2 subfamily B member 7, pseudogene",TRUE
+"206754_s_at",0.915766032166572,0.644765724953771,-0.467417319306789,-5.83382705829015,-0.837817382336239,"CYP2B7P///CYP2B6","cytochrome P450 family 2 subfamily B member 7, pseudogene///cytochrome P450 family 2 subfamily B member 6",TRUE
+"208126_s_at",0.958172521592984,0.81105119889023,0.241940915877247,-5.91121319031913,0.195020135084668,"CYP2C18","cytochrome P450 family 2 subfamily C member 18",TRUE
+"215103_at",0.985577528508055,0.930503378651981,0.0882084981884647,-5.93589448003001,0.0802367631645451,"CYP2C18","cytochrome P450 family 2 subfamily C member 18",TRUE
+"216058_s_at",0.924043155603915,0.673250777773893,0.427347376779971,-5.85112253734694,0.162372521179651,"CYP2C19","cytochrome P450 family 2 subfamily C member 19",TRUE
+"208147_s_at",0.835952408568777,0.416638740721572,0.827750432598942,-5.61136105927197,0.785330747021228,"CYP2C8","cytochrome P450 family 2 subfamily C member 8",TRUE
+"219903_s_at",0.895537461973113,0.574716387118657,0.569544213072502,-5.78291277562031,0.335738681269963,"CYP2C8","cytochrome P450 family 2 subfamily C member 8",TRUE
+"216661_x_at",0.603702127972549,0.077892864672486,1.848685782865,-4.39948026602581,0.59177135760795,"CYP2C9","cytochrome P450 family 2 subfamily C member 9",TRUE
+"214421_x_at",0.623667408398064,0.0953495357439309,1.74214437465082,-4.56054246340161,0.573416789965044,"CYP2C9","cytochrome P450 family 2 subfamily C member 9",TRUE
+"216025_x_at",0.819018525257656,0.373852809326173,0.907605411146292,-5.54623845277672,0.278815431587351,"CYP2C9","cytochrome P450 family 2 subfamily C member 9",TRUE
+"220017_x_at",0.901788521024914,0.599599340050415,0.532618318413417,-5.80244890772995,0.258281209491184,"CYP2C9","cytochrome P450 family 2 subfamily C member 9",TRUE
+"214419_s_at",0.917102138198416,0.649472130551537,0.46074479025734,-5.8368125201865,0.223733189480037,"CYP2C9","cytochrome P450 family 2 subfamily C member 9",TRUE
+"214420_s_at",0.949872235189194,0.772771228046649,0.292307439316386,-5.89815250848367,0.134398280448855,"CYP2C9","cytochrome P450 family 2 subfamily C member 9",TRUE
+"217558_at",0.975196332002567,0.879464730492789,-0.153408532288194,-5.92822734700966,-0.0501197161721318,"CYP2C9","cytochrome P450 family 2 subfamily C member 9",TRUE
+"217468_at",0.615821255316333,0.0867793718260468,1.79213309670571,-4.48583796124134,0.774567572741548,"CYP2D6","cytochrome P450 family 2 subfamily D member 6",TRUE
+"215809_at",0.820611742812032,0.381195758924404,0.893493259883222,-5.55815153798444,0.355797845213183,"CYP2D6","cytochrome P450 family 2 subfamily D member 6",TRUE
+"222100_at",0.64513208805899,0.115717585680478,1.63718551585878,-4.71223656833926,1.05568253507579,"CYP2E1","cytochrome P450 family 2 subfamily E member 1",TRUE
+"209976_s_at",0.681732274610686,0.14941056483299,1.49350249152844,-4.9080044568529,1.21496456394655,"CYP2E1","cytochrome P450 family 2 subfamily E member 1",TRUE
+"1431_at",0.825808541732306,0.393412621609536,0.870403515119968,-5.57727011842135,0.680876532812833,"CYP2E1","cytochrome P450 family 2 subfamily E member 1",TRUE
+"209975_at",0.896229101808264,0.580082802594037,-0.561514354604404,-5.78726918009368,-0.341327817171969,"CYP2E1","cytochrome P450 family 2 subfamily E member 1",TRUE
+"207913_at",0.776936981479994,0.295270663654271,-1.07197148466463,-5.39496982707122,-0.768435146918985,"CYP2F1","cytochrome P450 family 2 subfamily F member 1",TRUE
+"205073_at",0.769847953580141,0.278189784326433,-1.11168848154836,-5.35503097963531,-0.9144162146447,"CYP2J2","cytochrome P450 family 2 subfamily J member 2",TRUE
+"227109_at",0.56861088242915,0.0584381329530233,-1.99541000897424,-4.1667037611005,-1.33217498783164,"CYP2R1","cytochrome P450 family 2 subfamily R member 1",TRUE
+"207786_at",0.774230543658252,0.288572871591781,-1.0873427240504,-5.37966628086784,-0.877575671197045,"CYP2R1","cytochrome P450 family 2 subfamily R member 1",TRUE
+"239181_at",0.820293495506061,0.379101337008749,-0.897500074935258,-5.55478664426685,-0.356439304015025,"CYP2R1","cytochrome P450 family 2 subfamily R member 1",TRUE
+"223385_at",0.56861088242915,0.0586018504538732,1.9940054799316,-4.16898953031864,0.969354890389216,"CYP2S1","cytochrome P450 family 2 subfamily S member 1",TRUE
+"216720_at",0.806086691531913,0.346442751920857,0.961977370232606,-5.49873449363344,0.681931152547164,"CYP2U1","cytochrome P450 family 2 subfamily U member 1",TRUE
+"226402_at",0.914588178928864,0.640452221936635,-0.473551775013871,-5.83104526706208,-0.4036508282445,"CYP2U1","cytochrome P450 family 2 subfamily U member 1",TRUE
+"226393_at",0.91819942347705,0.652975399792129,-0.455791780689203,-5.83900142822588,-0.195946817146855,"CYP2U1","cytochrome P450 family 2 subfamily U member 1",TRUE
+"1554853_at",0.956960361976289,0.804954774877279,0.249916125012824,-5.90930816172605,0.120900074550875,"CYP2U1","cytochrome P450 family 2 subfamily U member 1",TRUE
+"220562_at",0.840879524142924,0.430448932228163,0.803098967464847,-5.6303330563096,0.657714498780356,"CYP2W1","cytochrome P450 family 2 subfamily W member 1",TRUE
+"1553977_a_at",0.561838781587612,0.0548428637829554,2.02717035295733,-4.11472943023229,0.860680022555568,"CYP39A1","cytochrome P450 family 39 subfamily A member 1",TRUE
+"220432_s_at",0.567651250567208,0.0577775355465213,2.00111297086711,-4.15741151585606,2.38843888702542,"CYP39A1","cytochrome P450 family 39 subfamily A member 1",TRUE
+"244407_at",0.702809964629668,0.174628035588113,1.40248151659635,-5.02453439341354,1.25483585873675,"CYP39A1","cytochrome P450 family 39 subfamily A member 1",TRUE
+"231704_at",0.597654932724127,0.0746324521229378,1.8708477743602,-4.36511634477635,0.834922374670821,"CYP3A4","cytochrome P450 family 3 subfamily A member 4",TRUE
+"205999_x_at",0.653793326711711,0.123073540401087,1.60310182146043,-4.75994617620438,1.02951187187134,"CYP3A4","cytochrome P450 family 3 subfamily A member 4",TRUE
+"210726_at",0.704449222279154,0.176352645301675,1.39665206951903,-5.0317928561771,0.873867022171676,"CYP3A4","cytochrome P450 family 3 subfamily A member 4",TRUE
+"208367_x_at",0.868313695469383,0.502560322096808,0.681591199422235,-5.71590854409823,0.302795209283522,"CYP3A4","cytochrome P450 family 3 subfamily A member 4",TRUE
+"205998_x_at",0.932091525948902,0.70029543993465,0.389951966412979,-5.86588960323817,0.244584020584357,"CYP3A4","cytochrome P450 family 3 subfamily A member 4",TRUE
+"207773_x_at",0.588653540532996,0.0672369518750329,1.92443538886288,-4.28083883456178,1.64644636077335,"CYP3A43","cytochrome P450 family 3 subfamily A member 43",TRUE
+"211440_x_at",0.683838837468118,0.152729598317615,-1.48084338556324,-4.92456682177837,-0.421148426514014,"CYP3A43","cytochrome P450 family 3 subfamily A member 43",TRUE
+"211442_x_at",0.823773334423331,0.391033549644904,0.874862960975595,-5.57361383554336,0.608895893042968,"CYP3A43","cytochrome P450 family 3 subfamily A member 43",TRUE
+"211441_x_at",0.985498770484702,0.930179778413299,-0.0886203501221118,-5.93585902189599,-0.0513114104546251,"CYP3A43","cytochrome P450 family 3 subfamily A member 43",TRUE
+"214235_at",0.741283193250232,0.231963679073035,1.22900384427533,-5.22961552214912,0.84521451161931,"CYP3A5","cytochrome P450 family 3 subfamily A member 5",TRUE
+"243015_at",0.791211889207316,0.321632919583373,1.01377606943297,-5.45113446542366,0.54424303286164,"CYP3A5","cytochrome P450 family 3 subfamily A member 5",TRUE
+"205765_at",0.802255823093278,0.339931979545432,0.975317054238444,-5.48669341144912,0.71058699602957,"CYP3A5","cytochrome P450 family 3 subfamily A member 5",TRUE
+"214234_s_at",0.94895689004559,0.768145554808988,0.298443584902118,-5.89639433279308,0.272345243393232,"CYP3A5","cytochrome P450 family 3 subfamily A member 5",TRUE
+"211843_x_at",0.974982245454858,0.878252611759165,-0.154964125896444,-5.92799396903387,-0.0724948932627663,"CYP3A7-CYP3A51P","CYP3A7-CYP3A51P readthrough",TRUE
+"205939_at",0.695744345349551,0.165587937033143,1.43381414592204,-4.98509531169603,1.17012703930364,"CYP3A7-CYP3A51P///CYP3A7","CYP3A7-CYP3A51P readthrough///cytochrome P450 family 3 subfamily A member 7",TRUE
+"243609_at",0.847880760418453,0.447526822973081,-0.773283087481297,-5.65255868684744,-0.48101652927871,"CYP3A7-CYP3A51P///CYP3A7","CYP3A7-CYP3A51P readthrough///cytochrome P450 family 3 subfamily A member 7",TRUE
+"220331_at",0.986342822130003,0.93508907240801,-0.0823738472915626,-5.93637907821477,-0.0526982193912335,"CYP46A1","cytochrome P450 family 46 subfamily A member 1",TRUE
+"207407_x_at",0.567292616148537,0.0572206207804865,2.00596599685904,-4.14949015127893,1.07496993396893,"CYP4A11","cytochrome P450 family 4 subfamily A member 11",TRUE
+"211231_x_at",0.910165867297668,0.626661553934994,0.493290002907852,-5.82185392204663,0.328193076926829,"CYP4A11","cytochrome P450 family 4 subfamily A member 11",TRUE
+"1554837_a_at",0.632949074657601,0.104157389621321,1.69462713829241,-4.63009774534621,1.24993043831058,"CYP4A22///CYP4A11","cytochrome P450 family 4 subfamily A member 22///cytochrome P450 family 4 subfamily A member 11",TRUE
+"217319_x_at",0.674325549770726,0.14073578140711,1.52770837457749,-4.86268732012977,1.07446887490339,"CYP4A22///CYP4A11","cytochrome P450 family 4 subfamily A member 22///cytochrome P450 family 4 subfamily A member 11",TRUE
+"1554931_at",0.859122424227944,0.475995155995655,-0.725074017035248,-5.68681232567071,-0.483394134368119,"CYP4A22///CYP4A11","cytochrome P450 family 4 subfamily A member 22///cytochrome P450 family 4 subfamily A member 11",TRUE
+"1555497_a_at",0.70629714980065,0.178373132957428,-1.38987999106014,-5.04019364270768,-1.57191901276,"CYP4B1","cytochrome P450 family 4 subfamily B member 1",TRUE
+"210096_at",0.801547748171611,0.338317837681136,-0.978651204894724,-5.48366020887416,-1.77420264660976,"CYP4B1","cytochrome P450 family 4 subfamily B member 1",TRUE
+"206153_at",0.661221664662217,0.128958353821184,1.57703865056146,-4.79590238424222,2.34193363751103,"CYP4F11","cytochrome P450 family 4 subfamily F member 11",TRUE
+"206539_s_at",0.767965891104819,0.270710687583294,1.12963751659736,-5.33655886961948,1.07294663154098,"CYP4F12","cytochrome P450 family 4 subfamily F member 12",TRUE
+"210452_x_at",0.769258076576208,0.275918072644911,1.11710272214219,-5.34948654636645,0.811955827510288,"CYP4F2","cytochrome P450 family 4 subfamily F member 2",TRUE
+"206514_s_at",0.840879524142924,0.430519061440195,0.802975053696103,-5.63042706172912,0.546282498957746,"CYP4F2///CYP4F3","cytochrome P450 family 4 subfamily F member 2///cytochrome P450 family 4 subfamily F member 3",TRUE
+"244692_at",0.992583835836326,0.965367815104327,-0.0439121044628262,-5.938744333747,-0.0475254545227513,"CYP4F22","cytochrome P450 family 4 subfamily F member 22",TRUE
+"206515_at",0.579625094592471,0.0624156040741877,1.96223324556035,-4.22040599524692,2.24654390541189,"CYP4F3","cytochrome P450 family 4 subfamily F member 3",TRUE
+"224278_at",0.836187222767049,0.417443625888004,-0.826299757005458,-5.61249239279865,-0.751771526054647,"CYP4F30P","cytochrome P450 family 4 subfamily F member 30, pseudogene",TRUE
+"241895_at",0.805335305758344,0.344699713312424,0.965531728151431,-5.49554094809868,1.39392367891779,"CYP4F62P","cytochrome P450 family 4 subfamily F member 62, pseudogene",TRUE
+"210576_at",0.758722841981575,0.255849894186628,-1.1664114763672,-5.29789948506942,-1.63187867235893,"CYP4F8","cytochrome P450 family 4 subfamily F member 8",TRUE
+"226745_at",0.963184997425306,0.83253184900765,0.213964069550378,-5.91740999447016,0.164427112116201,"CYP4V2","cytochrome P450 family 4 subfamily V member 2",TRUE
+"228391_at",0.973493137611142,0.872090256923988,0.162878833899923,-5.9267701871199,0.129139701510352,"CYP4V2","cytochrome P450 family 4 subfamily V member 2",TRUE
+"229959_at",0.981587171772385,0.912512752352374,-0.111131349035602,-5.93366995469747,-0.0858075708746666,"CYP4V2","cytochrome P450 family 4 subfamily V member 2",TRUE
+"235719_at",0.99135920925157,0.959409605353164,-0.051473319064774,-5.93839308812278,-0.0248257105486749,"CYP4V2","cytochrome P450 family 4 subfamily V member 2",TRUE
+"227702_at",0.896118635245982,0.578322661192667,0.564143949295032,-5.78584916218317,0.831968175005393,"CYP4X1","cytochrome P450 family 4 subfamily X member 1",TRUE
+"237395_at",0.497871139123625,0.0309214635951515,-2.30477016142394,-3.63849861397847,-2.45021568823899,"CYP4Z1","cytochrome P450 family 4 subfamily Z member 1",TRUE
+"1553434_at",0.407748633394319,0.0156061318052867,-2.61932284267925,-3.0573510055102,-3.21079463500732,"CYP4Z2P","cytochrome P450 family 4 subfamily Z member 2, pseudogene",TRUE
+"233942_at",0.980832655742,0.910238584342173,-0.114033078353244,-5.93335191843236,-0.0821433005193146,"CYP51A1-AS1","CYP51A1 antisense RNA 1",TRUE
+"207406_at",0.755049574909504,0.248921124370421,1.18410016201614,-5.27891742459154,1.2044127490078,"CYP7A1","cytochrome P450 family 7 subfamily A member 1",TRUE
+"207386_at",0.55937703282623,0.053484076968205,2.03965821685869,-4.09414458216916,1.55145640752104,"CYP7B1","cytochrome P450 family 7 subfamily B member 1",TRUE
+"235438_at",0.600155558263716,0.0764862172836136,1.85814610458852,-4.3848468128885,3.07465685813837,"CYP7B1","cytochrome P450 family 7 subfamily B member 1",TRUE
+"232494_at",0.774230543658252,0.289599491211337,1.08497013861583,-5.3820411076556,0.540285895087949,"CYP8B1","cytochrome P450 family 8 subfamily B member 1",TRUE
+"210764_s_at",0.910159094731364,0.62602989813148,0.49419879172154,-5.82142190230718,0.518361405577378,"CYR61","cysteine rich angiogenic inducer 61",TRUE
+"201289_at",0.929088231432081,0.687646672414253,0.407368086428895,-5.85917760021005,0.427483066570103,"CYR61","cysteine rich angiogenic inducer 61",TRUE
+"228739_at",0.990870307890695,0.956923119306578,0.0546296564510725,-5.93822999438875,0.0557974215994417,"CYS1","cystin 1",TRUE
+"230866_at",0.835952408568777,0.415827766202435,-0.829213871532225,-5.6102178904829,-0.977755385110714,"CYSLTR1","cysteinyl leukotriene receptor 1",TRUE
+"216288_at",0.867972140419125,0.50129864304438,0.683626170275227,-5.71458515749016,0.275399819882706,"CYSLTR1","cysteinyl leukotriene receptor 1",TRUE
+"231747_at",0.943824539742785,0.748577989402236,0.324533838146051,-5.88851470849331,0.233381830475786,"CYSLTR1","cysteinyl leukotriene receptor 1",TRUE
+"220813_at",0.975242094553739,0.879778213028892,-0.153006282265223,-5.92828731230747,-0.0797853648384583,"CYSLTR2","cysteinyl leukotriene receptor 2",TRUE
+"1569144_a_at",0.981158705865426,0.911036237695661,-0.113015198038028,-5.93346441272139,-0.0563911313500274,"CYSRT1","cysteine rich tail 1",TRUE
+"224707_at",0.889452275006221,0.557334415190881,0.59581867885051,-5.7682397201181,0.360711451004411,"CYSTM1","cysteine rich transmembrane module containing 1",TRUE
+"202879_s_at",0.464342841802699,0.0238786040876709,2.42549235561047,-3.42019520613746,1.41936733428219,"CYTH1","cytohesin 1",TRUE
+"202880_s_at",0.54295328972902,0.046134553005535,2.11256902531133,-3.97231880146473,0.859011732017137,"CYTH1","cytohesin 1",TRUE
+"1555842_at",0.693286330555422,0.162483238038174,-1.44489187782405,-4.97098090537205,-0.670346664890367,"CYTH2","cytohesin 2",TRUE
+"209158_s_at",0.78885145722244,0.315059721817901,-1.02796206012319,-5.43770382648933,-0.356526961530582,"CYTH2","cytohesin 2",TRUE
+"237234_at",0.950926616697165,0.775894858500784,0.288170301792332,-5.8993174671236,0.12566019737372,"CYTH2","cytohesin 2",TRUE
+"243752_s_at",0.48580305784244,0.028520788740412,2.34278210961389,-3.57044168230929,3.02536972657773,"CYTH3","cytohesin 3",TRUE
+"206523_at",0.522403182336918,0.0381789927122677,2.20436942767576,-3.81508947912124,2.54232748014379,"CYTH3","cytohesin 3",TRUE
+"225147_at",0.606900628956089,0.0807070985155926,1.83019646041852,-4.42792609677453,2.11046589911645,"CYTH3","cytohesin 3",TRUE
+"236136_at",0.796630089799502,0.329469117778642,-0.997126152010322,-5.46668217303628,-0.527095741744625,"CYTH3","cytohesin 3",TRUE
+"1554335_at",0.653375957820821,0.122782386611193,1.6044180572059,-4.75811816096804,0.554382474277977,"CYTH4","cytohesin 4",TRUE
+"211521_s_at",0.955645941042265,0.796758950203169,0.260663993476618,-5.90664370580535,0.153890202749684,"CYTH4","cytohesin 4",TRUE
+"219183_s_at",0.986889306520757,0.939515026134808,-0.0767452226911982,-5.93681516921755,-0.0242683318857022,"CYTH4","cytohesin 4",TRUE
+"209606_at",0.920169584950428,0.660352455204432,0.445399474716532,-5.84351875721029,0.365151102490902,"CYTIP","cytohesin 1 interacting protein",TRUE
+"219837_s_at",0.862634144901168,0.485816353160939,0.708839117842078,-5.69787632385493,0.278732904063577,"CYTL1","cytokine like 1",TRUE
+"235044_at",0.843095426822889,0.437264796529808,0.791113662729753,-5.6393623918509,0.705185926332712,"CYYR1","cysteine and tyrosine rich 1",TRUE
+"228665_at",0.903056266288086,0.60304503591119,0.527564653947945,-5.80502359891636,0.42099242680596,"CYYR1","cysteine and tyrosine rich 1",TRUE
+"1559470_at",0.696129677967645,0.1661822574889,-1.43171266772482,-4.98776283820762,-1.11604477053014,"D21S2088E","D21S2088E",TRUE
+"1559471_s_at",0.773642533214642,0.284982871731393,1.09568760745709,-5.37127680458279,0.596234493250346,"D21S2088E","D21S2088E",TRUE
+"1563362_at",0.959573917194453,0.81729318739954,0.233791864111262,-5.9130962847893,0.117526262483191,"D21S2090E","uncharacterized D21S2090E",TRUE
+"228738_at",0.0952827619788257,0.000400333455742558,-4.16286300666335,0.150943362941827,-1.79812575456089,"D2HGDH","D-2-hydroxyglutarate dehydrogenase",TRUE
+"232552_at",0.774230543658252,0.290328665056925,1.08328864439614,-5.38372138869527,0.600186355098129,"DAAM1","dishevelled associated activator of morphogenesis 1",TRUE
+"216060_s_at",0.813442508625161,0.36375031974488,0.927324167526699,-5.52930406192385,0.479588811059125,"DAAM1","dishevelled associated activator of morphogenesis 1",TRUE
+"226666_at",0.848923243270856,0.449436345673858,0.7699928293828,-5.65496277134365,0.390507708545684,"DAAM1","dishevelled associated activator of morphogenesis 1",TRUE
+"244062_at",0.947778780715578,0.762100868366842,-0.306479817708052,-5.89403696934439,-0.110844527735224,"DAAM1","dishevelled associated activator of morphogenesis 1",TRUE
+"1555989_at",0.958419239985859,0.811715799301055,-0.241072478369561,-5.91141692436155,-0.232935069899099,"DAAM1","dishevelled associated activator of morphogenesis 1",TRUE
+"212793_at",0.778421030796133,0.298355576065181,1.06497566414647,-5.40187032012649,0.59976001366329,"DAAM2","dishevelled associated activator of morphogenesis 2",TRUE
+"228329_at",0.767965891104819,0.270840795081025,-1.12932219375722,-5.33688563918706,-0.634034843651356,"DAB1","DAB1, reelin adaptor protein",TRUE
+"220611_at",0.95825706371645,0.811183838033832,-0.241767580308992,-5.91125391275576,-0.178262349205998,"DAB1","DAB1, reelin adaptor protein",TRUE
+"1569259_at",0.835952408568777,0.416829603756698,0.827406273128041,-5.61162962580981,0.580950527870707,"DAB1-AS1","DAB1 antisense RNA 1",TRUE
+"232898_at",0.816800680706682,0.368407099993453,0.918190077011177,-5.53719008478802,0.54159768708547,"DAB2","DAB2, clathrin adaptor protein",TRUE
+"235966_at",0.701911663048518,0.173491252207365,1.40634917933019,-5.01970486036392,0.849197112202433,"DAB2IP","DAB2 interacting protein",TRUE
+"225020_at",0.888830748858811,0.556047072675294,-0.597781324421601,-5.7671179958199,-0.296912680138167,"DAB2IP","DAB2 interacting protein",TRUE
+"228942_s_at",0.959451355429682,0.816845894394201,0.234375270119656,-5.91296360297514,0.223486024091778,"DAB2IP","DAB2 interacting protein",TRUE
+"228915_at",0.561986077568574,0.0548675204766538,-2.02694630519563,-4.11509798454753,-3.33957030622093,"DACH1","dachshund family transcription factor 1",TRUE
+"205472_s_at",0.694519360341564,0.164039980718932,-1.43931623531025,-4.97809605106112,-1.90993406473659,"DACH1","dachshund family transcription factor 1",TRUE
+"205471_s_at",0.855662813198157,0.468983036545207,-0.736785687638179,-5.67868307464664,-1.14228633280341,"DACH1","dachshund family transcription factor 1",TRUE
+"239738_at",0.857148066512338,0.471894884664289,0.731909873694244,-5.68208248002564,0.834428016535457,"DACH2","dachshund family transcription factor 2",TRUE
+"219179_at",0.695744345349551,0.165421770524211,1.43440278440569,-4.98434754559788,1.51446693676276,"DACT1","dishevelled binding antagonist of beta catenin 1",TRUE
+"1569648_at",0.922168942129244,0.667918273763038,-0.434792748858289,-5.84802387134936,-0.323578691535141,"DACT2","dishevelled binding antagonist of beta catenin 2",TRUE
+"228228_at",0.952807406768689,0.784069945428719,-0.27736675095643,-5.9022818980626,-0.0823723650377319,"DACT3","dishevelled binding antagonist of beta catenin 3",TRUE
+"229745_x_at",0.966593471043185,0.844773603845968,0.198099393296396,-5.92058753790538,0.156684284575861,"DACT3","dishevelled binding antagonist of beta catenin 3",TRUE
+"1561532_at",0.966593471043185,0.843991813943169,0.199110954946245,-5.92039220600063,0.121726138436159,"DACT3-AS1","DACT3 antisense RNA 1",TRUE
+"200046_at",0.61591966964196,0.0869892435546255,-1.7908591942293,-4.48776089756321,-0.551967246037915,"DAD1","defender against cell death 1",TRUE
+"212128_s_at",0.920147736488699,0.660014002848002,0.44587516623882,-5.84331421517431,0.166581035527289,"DAG1","dystroglycan 1",TRUE
+"205417_s_at",0.936992192746977,0.718183305241992,-0.365528615000407,-5.87481511085491,-0.133529914476597,"DAG1","dystroglycan 1",TRUE
+"214128_at",0.85069818933195,0.453765991147023,-0.76256373763406,-5.66035535040347,-0.570793349717922,"DAGLA","diacylglycerol lipase alpha",TRUE
+"225832_s_at",0.837609393049242,0.421789311371758,0.818497599631278,-5.61854515688611,0.300736436789087,"DAGLB","diacylglycerol lipase beta",TRUE
+"225833_at",0.932633693661011,0.702618065320848,0.386767396028351,-5.86708566367425,0.178758822014647,"DAGLB","diacylglycerol lipase beta",TRUE
+"225828_at",0.934447550624693,0.709389371166409,0.377506257099262,-5.87050900951799,0.130486781136707,"DAGLB","diacylglycerol lipase beta",TRUE
+"226640_at",0.956734254923335,0.803771173886669,0.251466391871403,-5.90893072243257,0.113238231312032,"DAGLB","diacylglycerol lipase beta",TRUE
+"221934_s_at",0.646392036827936,0.117343601761587,-1.62949830310914,-4.72306455043887,-0.678652413873523,"DALRD3","DALR anticodon binding domain containing 3",TRUE
+"218808_at",0.805267504135671,0.344538138532158,-0.965861826929145,-5.49524381242002,-0.362677851585939,"DALRD3","DALR anticodon binding domain containing 3",TRUE
+"224870_at",0.639656559005154,0.110025404997107,-1.66483209749881,-4.6729721676569,-0.796033983152359,"DANCR","differentiation antagonizing non-protein coding RNA",TRUE
+"1562772_a_at",0.639368659044705,0.109900076043935,1.66545425448185,-4.67208279545427,0.822725084296573,"DAND5","DAN domain BMP antagonist family member 5",TRUE
+"233551_at",0.675622576285316,0.142089626844767,1.52225820635464,-4.86996273456717,1.18387335191242,"DANT2","DXZ4 associated non-coding transcript 2, distal",TRUE
+"206878_at",0.789224993491684,0.315429033794405,1.0271595563068,-5.43846809824768,0.249944673274541,"DAO","D-amino acid oxidase",TRUE
+"1555640_at",0.595936234743389,0.0724360965727386,1.88625824793639,-4.34105087998425,0.92933176143695,"DAOA","D-amino acid oxidase activator",TRUE
+"1555662_s_at",0.918515815942389,0.653973181216375,-0.454383213510527,-5.83961968859721,-0.162087320672198,"DAOA","D-amino acid oxidase activator",TRUE
+"1553024_at",0.877333806479767,0.526989234757426,0.64273920612107,-5.7404496148597,0.265707107492873,"DAOA-AS1","DAOA antisense RNA 1",TRUE
+"201095_at",0.739189560382301,0.226060142828146,1.24521927308232,-5.21142225946306,0.674785074322271,"DAP","death associated protein",TRUE
+"227608_at",0.646392036827936,0.117270415595265,-1.62984237361356,-4.72258074089446,-0.393121380081569,"DAP3","death associated protein 3",TRUE
+"232516_x_at",0.901892339532073,0.599980060491774,-0.532059243017815,-5.80273491504417,-0.163379658999082,"DAP3","death associated protein 3",TRUE
+"208822_s_at",0.965784577131534,0.83996320460464,-0.204326987722413,-5.91936926369139,-0.067067076219848,"DAP3","death associated protein 3",TRUE
+"211214_s_at",0.458434216161719,0.0228483445640729,2.44585562231467,-3.38276540775043,2.3747681371796,"DAPK1","death associated protein kinase 1",TRUE
+"203139_at",0.486821797225537,0.0286843154641476,2.34010122912257,-3.57526247462159,2.2931546003331,"DAPK1","death associated protein kinase 1",TRUE
+"239162_at",0.471258057520525,0.0256250609055056,2.39276272968422,-3.47999655985391,1.35196813588241,"DAPK1-IT1","DAPK1 intronic transcript 1",TRUE
+"215184_at",0.843622137192279,0.438945817262843,0.788175420144597,-5.64155646857747,0.485248241990463,"DAPK2","death associated protein kinase 2",TRUE
+"206324_s_at",0.997763494670794,0.989061190958822,-0.0138657413746986,-5.93958983901782,-0.0090376707520825,"DAPK2","death associated protein kinase 2",TRUE
+"228681_x_at",0.966516333981852,0.843746220776475,0.199428772934117,-5.92033063094024,0.077584921481684,"DAPK3","death associated protein kinase 3",TRUE
+"229290_at",0.849276510852753,0.450135967224544,-0.768789448855152,-5.65583962492856,-0.380122101625047,"DAPL1","death associated protein like 1",TRUE
+"219290_x_at",0.0592928515268338,0.00012560805144721,4.63586690546728,1.17171989044433,1.8915178749878,"DAPP1","dual adaptor of phosphotyrosine and 3-phosphoinositides 1",TRUE
+"222859_s_at",0.112518135066489,0.000589470812050337,4.00478660257845,-0.19036498962251,3.30517259950154,"DAPP1","dual adaptor of phosphotyrosine and 3-phosphoinositides 1",TRUE
+"222858_s_at",0.153726668922469,0.00115839757834581,3.72762398663839,-0.786220009967487,2.44376665855285,"DAPP1","dual adaptor of phosphotyrosine and 3-phosphoinositides 1",TRUE
+"236707_at",0.672434875127089,0.138423404843511,1.53711776268723,-4.85007813775558,0.555192026458802,"DAPP1","dual adaptor of phosphotyrosine and 3-phosphoinositides 1",TRUE
+"201624_at",0.888312537451395,0.554264001274961,-0.60050366359849,-5.76555617932607,-0.196571650874974,"DARS","aspartyl-tRNA synthetase",TRUE
+"201623_s_at",0.919354071504066,0.656712623744695,0.450520729405196,-5.84130541736954,0.177273353656176,"DARS","aspartyl-tRNA synthetase",TRUE
+"243355_at",0.802565640893823,0.340288497399786,0.974582099357468,-5.48736075808743,0.616598239642565,"DARS-AS1","DARS antisense RNA 1",TRUE
+"218365_s_at",0.898405288322584,0.587718540956109,-0.550152676577071,-5.79333063223607,-0.242164545164067,"DARS2","aspartyl-tRNA synthetase 2, mitochondrial",TRUE
+"242162_at",0.787475262684958,0.313310246905698,1.03177262437435,-5.43406745195242,1.14389453091864,"DAW1","dynein assembly factor with WD repeats 1",TRUE
+"201763_s_at",0.766550448794594,0.267580990907531,1.13725621880594,-5.32863912225576,0.335160930041809,"DAXX","death domain associated protein",TRUE
+"216038_x_at",0.945432830098469,0.753389354815916,0.318098015147747,-5.89051915715555,0.111481444606586,"DAXX","death domain associated protein",TRUE
+"208281_x_at",0.634743115037769,0.105690198593811,1.68670973486339,-4.64154681479763,0.821604898635289,"DAZ4///DAZ2///DAZ3///DAZ1","deleted in azoospermia 4///deleted in azoospermia 2///deleted in azoospermia 3///deleted in azoospermia 1",TRUE
+"207909_x_at",0.778291838199375,0.297747742463968,1.06634997795451,-5.40051792557428,0.807456769429321,"DAZ4///DAZ2///DAZ3///DAZ1","deleted in azoospermia 4///deleted in azoospermia 2///deleted in azoospermia 3///deleted in azoospermia 1",TRUE
+"216922_x_at",0.819930590292987,0.37798537774732,0.899640949010103,-5.55298304607622,0.46484120329109,"DAZ4///DAZ2///DAZ3///DAZ1","deleted in azoospermia 4///deleted in azoospermia 2///deleted in azoospermia 3///deleted in azoospermia 1",TRUE
+"207912_s_at",0.87499007563216,0.521841360516022,-0.650842149892714,-5.73544533727128,-0.571301031337445,"DAZ4///DAZ2///DAZ3///DAZ1","deleted in azoospermia 4///deleted in azoospermia 2///deleted in azoospermia 3///deleted in azoospermia 1",TRUE
+"208282_x_at",0.940044918888428,0.731015936383956,0.348146831564647,-5.88082021503949,0.278926950009057,"DAZ4///DAZ2///DAZ3///DAZ1","deleted in azoospermia 4///deleted in azoospermia 2///deleted in azoospermia 3///deleted in azoospermia 1",TRUE
+"216351_x_at",0.988065316951061,0.942840165349991,0.0725182193142063,-5.93712239285779,0.0403746228599164,"DAZ4///DAZ2///DAZ3///DAZ1","deleted in azoospermia 4///deleted in azoospermia 2///deleted in azoospermia 3///deleted in azoospermia 1",TRUE
+"218443_s_at",0.831875452294783,0.406772927748284,0.845677869792095,-5.5972269770574,0.215582583458643,"DAZAP1","DAZ associated protein 1",TRUE
+"226620_x_at",0.9340157600858,0.707578238063523,-0.379980024541485,-5.86960259831986,-0.120452500417226,"DAZAP1","DAZ associated protein 1",TRUE
+"229813_x_at",0.949820165200312,0.772711494249838,0.292386605153261,-5.89813005592048,0.0897740575059043,"DAZAP1","DAZ associated protein 1",TRUE
+"200794_x_at",0.876039291047695,0.524634292333265,-0.646440568358294,-5.73817116953697,-0.196462636142648,"DAZAP2","DAZ associated protein 2",TRUE
+"212595_s_at",0.892000472179706,0.562174827619154,-0.588460117932869,-5.77241366110974,-0.202447048517913,"DAZAP2","DAZ associated protein 2",TRUE
+"238300_s_at",0.943966108617097,0.74888830408162,-0.324118333017674,-5.88864531853645,-0.174545139122717,"DAZAP2","DAZ associated protein 2",TRUE
+"214334_x_at",0.953347665529526,0.785206256499782,-0.275867786778647,-5.9026843246589,-0.069386370228246,"DAZAP2","DAZ associated protein 2",TRUE
+"206588_at",0.801086839730802,0.337344635135484,0.980666716713682,-5.48182204723458,0.972523525157185,"DAZL","deleted in azoospermia like",TRUE
+"204244_s_at",0.896229101808264,0.58005231968252,-0.561559861012885,-5.78724466071347,-0.161773319235641,"DBF4","DBF4 zinc finger",TRUE
+"206661_at",0.849935057946582,0.452338805604118,0.765007844976743,-5.6585866907374,0.562784140218668,"DBF4B","DBF4 zinc finger B",TRUE
+"238757_at",0.879351905683528,0.533336781790059,0.632807122612396,-5.74650134505476,0.260334674471995,"DBF4B","DBF4 zinc finger B",TRUE
+"238508_at",0.891390319214715,0.560829123619022,0.590502597679768,-5.77126014854501,0.242528643303041,"DBF4B","DBF4 zinc finger B",TRUE
+"1555378_at",0.931370027472813,0.695668927193192,0.396307706749617,-5.86347362731482,0.282669308855723,"DBF4B","DBF4 zinc finger B",TRUE
+"234916_at",0.728385463227073,0.2091300566477,1.29359232482133,-5.15593680392246,0.658098256358595,"DBH","dopamine beta-hydroxylase",TRUE
+"206450_at",0.894692956611947,0.57149075110591,-0.574389018720121,-5.78025534917725,-0.317814430729161,"DBH","dopamine beta-hydroxylase",TRUE
+"230488_s_at",0.903021267024792,0.602941461996688,0.527716358462103,-5.80494665783134,0.288584110197361,"DBH-AS1","DBH antisense RNA 1",TRUE
+"209389_x_at",0.597654932724127,0.0749419260568963,-1.86870831745409,-4.36844638207192,-0.613979114481232,"DBI","diazepam binding inhibitor, acyl-CoA binding protein",TRUE
+"202428_x_at",0.626839388794963,0.0973554234277948,-1.73100333563446,-4.57697925971372,-0.447292056398354,"DBI","diazepam binding inhibitor, acyl-CoA binding protein",TRUE
+"211070_x_at",0.707648051552537,0.179083183254525,-1.38751460106534,-5.04311995307246,-0.395525397622267,"DBI","diazepam binding inhibitor, acyl-CoA binding protein",TRUE
+"223783_s_at",0.947326616179611,0.760332551520078,-0.308834618687836,-5.89333444856393,-0.224811388471988,"DBIL5P","diazepam binding inhibitor-like 5, pseudogene",TRUE
+"224258_at",0.997674669021782,0.988710125007848,0.0143107744288754,-5.93958373155745,0.0108617506638709,"DBIL5P2","diazepam binding inhibitor-like 5 pseudogene 2",TRUE
+"202806_at",0.985498770484702,0.929763545517042,0.08915012043377,-5.93581316896085,0.0482031635764972,"DBN1","drebrin 1",TRUE
+"217025_s_at",0.995261077491356,0.978054481167289,-0.0278203705379752,-5.93930651405982,-0.0188089421375341,"DBN1","drebrin 1",TRUE
+"222234_s_at",0.627092759817312,0.0980062057616154,-1.72743091362273,-4.58223319471963,-1.17805004787138,"DBNDD1","dysbindin domain containing 1",TRUE
+"209782_s_at",0.724970327905974,0.203003433634161,-1.3118432333278,-5.13453538034682,-0.754703248879704,"DBP","D-box binding PAR bZIP transcription factor",TRUE
+"209783_at",0.973615804712521,0.873059982881355,0.161632659433031,-5.92696690480069,0.104744135703561,"DBP","D-box binding PAR bZIP transcription factor",TRUE
+"1555646_at",0.215142544130694,0.0025813170361177,3.39534927346936,-1.49155584535965,2.39537830059791,"Dbpht2","DNA binding protein with his-thr domain",TRUE
+"234295_at",0.617775129514679,0.0885706352988015,-1.78134457383559,-4.5020915571638,-0.512510081941695,"DBR1","debranching RNA lariats 1",TRUE
+"219149_x_at",0.812302873476553,0.357715923502588,-0.93927748728544,-5.51887560636825,-0.264077412030829,"DBR1","debranching RNA lariats 1",TRUE
+"244687_at",0.591331966259927,0.068842526338795,1.91237714508461,-4.29994746105017,0.610445724279208,"DBT","dihydrolipoamide branched chain transacylase E2",TRUE
+"205370_x_at",0.849935057946582,0.452419376690168,-0.764869740180153,-5.65868677179698,-0.266965976646208,"DBT","dihydrolipoamide branched chain transacylase E2",TRUE
+"211196_at",0.860087570848245,0.479533914590485,0.7192019920959,-5.69084159363049,0.552910950899578,"DBT","dihydrolipoamide branched chain transacylase E2",TRUE
+"231919_at",0.9116561917482,0.63025049941576,0.488134398708477,-5.82429008637796,0.173507407029204,"DBT","dihydrolipoamide branched chain transacylase E2",TRUE
+"205369_x_at",0.933298127911264,0.704840034116348,0.383724643492832,-5.86821942865362,0.169172913186285,"DBT","dihydrolipoamide branched chain transacylase E2",TRUE
+"205371_s_at",0.997654912087849,0.988377482751724,0.0147324551921744,-5.93957776656995,0.00541320190737338,"DBT","dihydrolipoamide branched chain transacylase E2",TRUE
+"226476_s_at",0.646750698976317,0.117846049304598,1.62714099070572,-4.72637713406619,0.533253034264521,"DCAF1","DDB1 and CUL4 associated factor 1",TRUE
+"204377_s_at",0.662575055303091,0.130436947224993,1.5706458577606,-4.80465135294899,0.853871180029458,"DCAF1","DDB1 and CUL4 associated factor 1",TRUE
+"204376_at",0.842319515384785,0.436003376404295,0.793323055568183,-5.63770750858882,0.685409583800633,"DCAF1","DDB1 and CUL4 associated factor 1",TRUE
+"226477_at",0.864894115958506,0.493507552831407,0.696257398502098,-5.70628650792131,0.194650440120519,"DCAF1","DDB1 and CUL4 associated factor 1",TRUE
+"226481_at",0.937257436560633,0.721692511736674,0.360764218636696,-5.87648986855848,0.102636022908589,"DCAF1","DDB1 and CUL4 associated factor 1",TRUE
+"226511_at",0.627938764248877,0.0993315823383458,-1.72021751475456,-4.5928172349068,-0.9817456793942,"DCAF10","DDB1 and CUL4 associated factor 10",TRUE
+"222804_x_at",0.725143559947316,0.20330019858672,-1.31094939151702,-5.13558942989073,-0.675260964511738,"DCAF10","DDB1 and CUL4 associated factor 10",TRUE
+"219001_s_at",0.734861913384601,0.219859196203429,-1.26260326410934,-5.19169043004523,-0.713207388023282,"DCAF10","DDB1 and CUL4 associated factor 10",TRUE
+"230679_at",0.774230543658252,0.288753972623857,-1.08692374659191,-5.38008599040273,-0.652130021879358,"DCAF10","DDB1 and CUL4 associated factor 10",TRUE
+"201886_at",0.743474458360704,0.233775191259994,-1.22409101045929,-5.23508697576115,-0.503344247339637,"DCAF11","DDB1 and CUL4 associated factor 11",TRUE
+"216389_s_at",0.8288884913487,0.399686940977808,-0.858725635773251,-5.58676243725454,-0.292276568693836,"DCAF11","DDB1 and CUL4 associated factor 11",TRUE
+"224789_at",0.683019114815084,0.15189721468498,-1.4839969741465,-4.92045148765404,-0.582636111123783,"DCAF12","DDB1 and CUL4 associated factor 12",TRUE
+"238205_at",0.777547149102231,0.296504395950493,-1.06916744321642,-5.39774051517912,-0.638303196725816,"DCAF12L1","DDB1 and CUL4 associated factor 12 like 1",TRUE
+"239330_at",0.748438284778152,0.241314283292117,-1.20394893251125,-5.25732093234081,-1.23350606506639,"DCAF12L2","DDB1 and CUL4 associated factor 12 like 2",TRUE
+"231784_s_at",0.875938621758472,0.52426543183506,-0.647021144468974,-5.73781264450936,-0.243233984855287,"DCAF13","DDB1 and CUL4 associated factor 13",TRUE
+"1568840_at",0.930457281281851,0.692373785766825,-0.400844592383508,-5.86172551219618,-0.323562587515279,"DCAF13","DDB1 and CUL4 associated factor 13",TRUE
+"220843_s_at",0.948815741515659,0.767178530346672,0.2997278542453,-5.89602177117426,0.191885664442157,"DCAF13","DDB1 and CUL4 associated factor 13",TRUE
+"225676_s_at",0.993516281527979,0.96963918241636,-0.0384932030548055,-5.93896181208278,-0.0144926810384334,"DCAF13","DDB1 and CUL4 associated factor 13",TRUE
+"91952_at",0.7717895132349,0.281717168132477,1.10334492673002,-5.36352836861285,0.455438695277472,"DCAF15","DDB1 and CUL4 associated factor 15",TRUE
+"221851_at",0.848475456105025,0.448844211701051,0.771012213955821,-5.65421897489739,0.345109923126124,"DCAF15","DDB1 and CUL4 associated factor 15",TRUE
+"221849_s_at",0.885029460971826,0.545990246243984,0.613196342751123,-5.758183931642,0.232439139430944,"DCAF15","DDB1 and CUL4 associated factor 15",TRUE
+"222012_at",0.890816525789205,0.559712756785203,0.592198919864097,-5.77029919483494,0.234097006821719,"DCAF15","DDB1 and CUL4 associated factor 15",TRUE
+"219717_at",0.882023958362664,0.539370197752462,0.623425616107633,-5.75213431346919,0.270844276583439,"DCAF16","DDB1 and CUL4 associated factor 16",TRUE
+"228106_at",0.927552865877291,0.682550541169299,0.41442104266825,-5.85637736159985,0.177016803888007,"DCAF16","DDB1 and CUL4 associated factor 16",TRUE
+"239187_at",0.945498722604777,0.754061805649556,-0.317199622320465,-5.89079580109541,-0.124140444224436,"DCAF16","DDB1 and CUL4 associated factor 16",TRUE
+"220172_at",0.760374043437572,0.259104321962239,-1.15822585745312,-5.30659893262646,-0.359856096541264,"DCAF17","DDB1 and CUL4 associated factor 17",TRUE
+"231921_at",0.924029559540466,0.67321067169154,0.427403281793183,-5.8510994663234,0.195287797504896,"DCAF17","DDB1 and CUL4 associated factor 17",TRUE
+"226938_at",0.834454640870101,0.412931042768751,-0.834455904621407,-5.60610756563803,-0.349912095382702,"DCAF4","DDB1 and CUL4 associated factor 4",TRUE
+"214758_at",0.937842878751575,0.724973557758305,0.356317278291528,-5.87803345647487,0.131894474934798,"DCAF4","DDB1 and CUL4 associated factor 4",TRUE
+"1562209_at",0.970893641742918,0.860992210581566,0.177160036592608,-5.92440822559032,0.173381961259265,"DCAF4L1","DDB1 and CUL4 associated factor 4 like 1",TRUE
+"1553199_at",0.687659256779784,0.1566460853713,-1.46619003342085,-4.94359618761138,-1.24206068300258,"DCAF4L2","DDB1 and CUL4 associated factor 4 like 2",TRUE
+"1553197_at",0.957571530817866,0.808603111393676,0.245141494029343,-5.91045605050624,0.166247881642113,"DCAF4L2","DDB1 and CUL4 associated factor 4 like 2",TRUE
+"224697_at",0.384664730952718,0.0125935046804822,-2.71512968354298,-2.87295736359379,-1.06385510327536,"DCAF5","DDB1 and CUL4 associated factor 5",TRUE
+"227251_at",0.445496822354337,0.0208155661302223,-2.48866558671942,-3.30353055986847,-0.747545651705188,"DCAF5","DDB1 and CUL4 associated factor 5",TRUE
+"224696_s_at",0.504875670074508,0.0328180198328934,-2.27660870199894,-3.68850140836697,-0.86842508985038,"DCAF5","DDB1 and CUL4 associated factor 5",TRUE
+"224703_at",0.728385463227073,0.209146284979879,-1.29354453538658,-5.15599250899899,-0.617217995031803,"DCAF5","DDB1 and CUL4 associated factor 5",TRUE
+"1554558_at",0.919375181609246,0.657174704929016,-0.449869903974791,-5.84158807215605,-0.25757013824856,"DCAF5","DDB1 and CUL4 associated factor 5",TRUE
+"217908_s_at",0.830635993561085,0.403514879008397,-0.851658846340601,-5.59244866646115,-0.382188203391511,"DCAF6","DDB1 and CUL4 associated factor 6",TRUE
+"241209_at",0.908801761853008,0.62117991472763,0.501190809001137,-5.81807207321246,0.606225744770412,"DCAF6","DDB1 and CUL4 associated factor 6",TRUE
+"232349_x_at",0.924784149419903,0.674521574663307,-0.425576692335789,-5.85185173353224,-0.199576833783443,"DCAF6","DDB1 and CUL4 associated factor 6",TRUE
+"233782_at",0.708675738217514,0.180658846625985,1.38229209093862,-5.04956628134982,0.381918640745794,"DCAF7","DDB1 and CUL4 associated factor 7",TRUE
+"221744_at",0.790817398514927,0.320707855436622,-1.01576016527491,-5.4492661663745,-0.40180764787001,"DCAF7","DDB1 and CUL4 associated factor 7",TRUE
+"224730_at",0.826379603754428,0.39460665194002,-0.86817194853531,-5.57909325331227,-0.315264213058972,"DCAF7","DDB1 and CUL4 associated factor 7",TRUE
+"224748_at",0.837345289209351,0.420113021627115,-0.821501166926405,-5.61622141450932,-0.31672629467282,"DCAF7","DDB1 and CUL4 associated factor 7",TRUE
+"236134_at",0.86481525165637,0.492417622374456,0.698033485658757,-5.70510799903367,0.387727116236756,"DCAF7","DDB1 and CUL4 associated factor 7",TRUE
+"221745_at",0.907576524801672,0.616853246239688,-0.507449817207755,-5.81503446623731,-0.181027570424812,"DCAF7","DDB1 and CUL4 associated factor 7",TRUE
+"209592_s_at",0.91876780831279,0.654458445690632,-0.453698503504313,-5.83991954981829,-0.192165873319652,"DCAF7","DDB1 and CUL4 associated factor 7",TRUE
+"202249_s_at",0.399841271548557,0.0142471552366487,-2.6601638053568,-2.97912932728376,-0.8947274818812,"DCAF8","DDB1 and CUL4 associated factor 8",TRUE
+"202250_s_at",0.539609110035715,0.0443471975082411,-2.13187216214765,-3.93960638391674,-0.786401084755486,"DCAF8","DDB1 and CUL4 associated factor 8",TRUE
+"216885_s_at",0.734614760371776,0.219209423132561,-1.26444650750745,-5.18958449927379,-0.429045496669207,"DCAF8","DDB1 and CUL4 associated factor 8",TRUE
+"1554049_s_at",0.820611742812032,0.381111845729916,-0.893653514909895,-5.55801722447106,-0.611842579424843,"DCAF8","DDB1 and CUL4 associated factor 8",TRUE
+"232339_at",0.831732794659972,0.406491419639122,-0.846193439414377,-5.59681631633851,-0.648754235334879,"DCAF8","DDB1 and CUL4 associated factor 8",TRUE
+"238338_at",0.869056640409671,0.505490631236555,0.676875988159177,-5.71896045122772,0.205432177655766,"DCAF8","DDB1 and CUL4 associated factor 8",TRUE
+"238340_at",0.92148618812595,0.665448815188728,-0.438249121352078,-5.84656751340478,-0.214041162070927,"DCAF8","DDB1 and CUL4 associated factor 8",TRUE
+"233637_at",0.961285315706981,0.824432429711353,0.224491195909017,-5.91516706926127,0.104044142893901,"DCAF8","DDB1 and CUL4 associated factor 8",TRUE
+"243318_at",0.98693003519805,0.939721989659162,0.0764820842784257,-5.9368348020438,0.0232511112971476,"DCAF8","DDB1 and CUL4 associated factor 8",TRUE
+"221224_s_at",0.812302873476553,0.359492094822287,-0.935745173994423,-5.52197008279162,-0.444455663475384,"DCAKD","dephospho-CoA kinase domain containing",TRUE
+"221225_at",0.852409445602775,0.458328905017474,0.754780493757081,-5.6659519723715,0.588396211886066,"DCAKD","dephospho-CoA kinase domain containing",TRUE
+"224522_s_at",0.923708852928185,0.672295204921702,-0.42867975408904,-5.8505718817318,-0.182276067244246,"DCAKD","dephospho-CoA kinase domain containing",TRUE
+"226609_at",0.406795337445118,0.0154447384188153,2.62399409989316,-3.04843379278999,1.40880805094151,"DCBLD1","discoidin, CUB and LCCL domain containing 1",TRUE
+"1553768_a_at",0.422574093216884,0.0176292388021111,2.56432558932499,-3.16174930288499,1.4354080105475,"DCBLD1","discoidin, CUB and LCCL domain containing 1",TRUE
+"213865_at",0.482262518773694,0.0274584418485613,2.36055094407456,-3.53841033945861,3.89139414800014,"DCBLD2","discoidin, CUB and LCCL domain containing 2",TRUE
+"224911_s_at",0.571677937624457,0.0596020702961441,1.98549943356594,-4.18280937345424,3.11768678377741,"DCBLD2","discoidin, CUB and LCCL domain containing 2",TRUE
+"230175_s_at",0.654547695781813,0.123423892682529,1.60152140383918,-4.76213955328926,2.38845290848187,"DCBLD2","discoidin, CUB and LCCL domain containing 2",TRUE
+"239446_x_at",0.756313947022433,0.251544401679124,1.17736046299011,-5.28617936700037,0.550120771383657,"DCBLD2","discoidin, CUB and LCCL domain containing 2",TRUE
+"242653_at",0.791211889207316,0.321585627557769,1.01387740561927,-5.45103912357847,0.805398728189023,"DCC","DCC netrin 1 receptor",TRUE
+"238914_at",0.978999293602992,0.898434781696253,-0.129110871669315,-5.93156758488885,-0.133975456842917,"DCC","DCC netrin 1 receptor",TRUE
+"206939_at",0.99783553534859,0.989206002297546,-0.013682170348233,-5.93959230207279,-0.0090722249392714,"DCC","DCC netrin 1 receptor",TRUE
+"1553946_at",0.869664655152884,0.507117485790292,-0.674264832029492,-5.72064179469444,-0.540014542484339,"DCD","dermcidin",TRUE
+"222926_at",0.746535697909741,0.238332019650102,-1.21185902866285,-5.24862743900202,-1.29163436464077,"DCDC2","doublecortin domain containing 2",TRUE
+"222925_at",0.941311073534434,0.73731130866882,-0.339659899673635,-5.88364725876108,-0.369686476875231,"DCDC2","doublecortin domain containing 2",TRUE
+"233918_at",0.778481681746654,0.298465250566198,1.06472790263789,-5.40211396383882,0.516947449046018,"DCDC2B","doublecortin domain containing 2B",TRUE
+"232603_at",0.945272089973488,0.752849752960774,0.318819115213412,-5.8902965467939,0.366131907802835,"DCDC5///DCDC1","doublecortin domain containing 5///doublecortin domain containing 1",TRUE
+"222101_s_at",0.935094665155941,0.711612598588173,0.374472898124974,-5.87161248949408,0.378425510191141,"DCHS1","dachsous cadherin-related 1",TRUE
+"218892_at",0.946277807642742,0.756655364821339,-0.313737118978264,-5.89185476798474,-0.247646553159232,"DCHS1","dachsous cadherin-related 1",TRUE
+"242764_at",0.690823350461169,0.160440128009655,1.45227523518417,-4.96152442910595,1.01742368944538,"DCHS2","dachsous cadherin-related 2",TRUE
+"220373_at",0.9990919116341,0.997045303602952,-0.00374517774654201,-5.93967664903038,-0.00150941848357711,"DCHS2","dachsous cadherin-related 2",TRUE
+"203302_at",0.873230718105642,0.517716707271487,-0.657366253559713,-5.73137240603135,-0.195678797573649,"DCK","deoxycytidine kinase",TRUE
+"215303_at",0.698391916012681,0.169524438208349,1.42000607113208,-5.00256402229943,1.16392705619529,"DCLK1","doublecortin like kinase 1",TRUE
+"230962_at",0.768852835478002,0.273834329044742,1.12209762087631,-5.34435038440443,1.02597479646984,"DCLK1","doublecortin like kinase 1",TRUE
+"229800_at",0.886783047600321,0.55021196456303,-0.606707293313403,-5.76197153667865,-0.626013664412984,"DCLK1","doublecortin like kinase 1",TRUE
+"205399_at",0.972659629123427,0.867821197630729,0.168368081620124,-5.92588573179597,0.205187382503549,"DCLK1","doublecortin like kinase 1",TRUE
+"216725_at",0.746535697909741,0.238450632430631,1.21154300203736,-5.2489757109356,0.574150436199264,"DCLK2","doublecortin like kinase 2",TRUE
+"216724_at",0.832605695407954,0.409197491961774,-0.841246770569882,-5.60074679724556,-0.73007463590855,"DCLK2","doublecortin like kinase 2",TRUE
+"227666_at",0.92777930247318,0.683073563150292,-0.413696210192149,-5.85666732216738,-0.32307311904747,"DCLK2","doublecortin like kinase 2",TRUE
+"232399_at",0.985709215004606,0.930829708080629,0.0877931885943012,-5.9359300687174,0.0764818327940553,"DCLK3","doublecortin like kinase 3",TRUE
+"209804_at",0.793016712530949,0.324846969532265,1.0069132865438,-5.45757120971985,0.347345437591349,"DCLRE1A","DNA cross-link repair 1A",TRUE
+"222889_at",0.634072872504683,0.104902444786759,-1.69076645668001,-4.63568558751946,-0.909602053582923,"DCLRE1B","DNA cross-link repair 1B",TRUE
+"219490_s_at",0.877333806479767,0.526959989397975,-0.642785116823137,-5.74042143062536,-0.385058291611118,"DCLRE1B","DNA cross-link repair 1B",TRUE
+"222233_s_at",0.591331966259927,0.0686843450357362,1.91355409030998,-4.29808603088424,0.644795939075465,"DCLRE1C","DNA cross-link repair 1C",TRUE
+"219678_x_at",0.603702127972549,0.0776918261145668,1.8500287015036,-4.39740624203811,0.558418524198878,"DCLRE1C","DNA cross-link repair 1C",TRUE
+"235478_at",0.740610299769501,0.23018393732634,1.23385894638719,-5.22418978568516,0.372102540174664,"DCLRE1C","DNA cross-link repair 1C",TRUE
+"239376_at",0.775251696888111,0.291639266604383,1.08027398139604,-5.38672805387637,0.313644336969135,"DCLRE1C","DNA cross-link repair 1C",TRUE
+"242927_at",0.960029104619887,0.819026282497956,0.231532162695925,-5.91360709544507,0.187472317552102,"DCLRE1C","DNA cross-link repair 1C",TRUE
+"201893_x_at",0.689264172124397,0.158376329115662,1.45981086079872,-4.95183252811797,0.470785057091614,"DCN","decorin",TRUE
+"211813_x_at",0.712253584217333,0.186338825215267,1.36376057749477,-5.07227730527419,0.848053437481585,"DCN","decorin",TRUE
+"240556_at",0.885029460971826,0.545708118026139,0.61363093610309,-5.75792887447921,0.513324829688763,"DCN","decorin",TRUE
+"209335_at",0.899255754020412,0.589645772288769,0.547296625409869,-5.79483541152986,0.425481708464502,"DCN","decorin",TRUE
+"242605_at",0.902810270244072,0.602435566845469,-0.528457522386397,-5.80457044671796,-0.439157244066851,"DCN","decorin",TRUE
+"211896_s_at",0.956960361976289,0.804870848339026,0.250026030357302,-5.9092814797757,0.157090888002925,"DCN","decorin",TRUE
+"239786_at",0.963982994746471,0.835103357438268,0.210627004524115,-5.91809861221269,0.132515233064052,"DCN","decorin",TRUE
+"225443_at",0.685154158710982,0.153594159300113,-1.47758264984673,-4.92881455313533,-0.459061968508008,"DCP1A","decapping mRNA 1A",TRUE
+"218508_at",0.721907781985393,0.198112619275593,-1.32672291281143,-5.11689969677233,-0.44958705219636,"DCP1A","decapping mRNA 1A",TRUE
+"226093_at",0.743553048228796,0.234225476377274,-1.22287431287569,-5.23643909398121,-1.25269657271003,"DCP1B","decapping mRNA 1B",TRUE
+"235258_at",0.623503825356688,0.094663104788036,-1.7460029897846,-4.55483148708879,-0.709238776453274,"DCP2","decapping mRNA 2",TRUE
+"212919_at",0.697172073261335,0.167335255261011,-1.42765290592397,-4.99290705722119,-0.512506524921987,"DCP2","decapping mRNA 2",TRUE
+"244777_at",0.952416163126023,0.782348691693021,-0.27963858010445,-5.90166785432944,-0.100443213061903,"DCP2","decapping mRNA 2",TRUE
+"238779_at",0.974699750720383,0.876395064447763,0.15734880276832,-5.92763164715966,0.095583481562274,"DCP2","decapping mRNA 2",TRUE
+"218774_at",0.954723352940649,0.794065476027574,-0.26420296846275,-5.90574198442608,-0.0937310038387302,"DCPS","decapping enzyme, scavenger",TRUE
+"1553860_at",0.710824498521146,0.184200052923701,1.37068536713572,-5.06382057287099,0.62874882103831,"DCST1","DC-STAMP domain containing 1",TRUE
+"242988_at",0.980264692225439,0.907729434908667,-0.117235797852687,-5.93299138837398,-0.0588218319763261,"DCST2","DC-STAMP domain containing 2",TRUE
+"221266_s_at",0.976371465776674,0.88626147011112,-0.144692879675438,-5.92949145443386,-0.0841368127728659,"DCSTAMP","dendrocyte expressed seven transmembrane protein",TRUE
+"205337_at",0.6708432030569,0.136530238591652,1.54491814902483,-4.83957859924848,1.23584482545214,"DCT","dopachrome tautomerase",TRUE
+"205338_s_at",0.727286289873957,0.207611583864226,1.29807670855945,-5.15070187248415,0.39893284304642,"DCT","dopachrome tautomerase",TRUE
+"216512_s_at",0.793626533839716,0.325376622658879,1.00578689022034,-5.45862389521165,0.436480088720279,"DCT","dopachrome tautomerase",TRUE
+"216513_at",0.90916193385564,0.623085630059528,0.498440417641414,-5.81939524964576,0.389926222658584,"DCT","dopachrome tautomerase",TRUE
+"210137_s_at",0.828607509614823,0.398887212311735,0.860207504188903,-5.585564515256,0.492752806727152,"DCTD","dCMP deaminase",TRUE
+"201571_s_at",0.837337084923913,0.419999363382291,0.821705091253482,-5.61606335716803,0.451927700958946,"DCTD","dCMP deaminase",TRUE
+"201572_x_at",0.843424227955276,0.437976682597999,0.789868516685869,-5.64029311936399,0.454266704974698,"DCTD","dCMP deaminase",TRUE
+"211780_x_at",0.884024105338928,0.542650049493549,0.618349293273065,-5.75514851978373,0.149683771424144,"DCTN1","dynactin subunit 1",TRUE
+"1557617_at",0.819426379375942,0.376359126454296,0.902768240873755,-5.55034129223003,0.712000942539096,"DCTN1-AS1","DCTN1 antisense RNA 1",TRUE
+"232505_at",0.769258076576208,0.276227577090135,1.11636316459158,-5.3502452950621,0.709720813604047,"DCTN2","dynactin subunit 2",TRUE
+"214384_s_at",0.769646142132413,0.277076886911807,1.11433684499212,-5.35232191555726,0.922437158329435,"DCTN2","dynactin subunit 2",TRUE
+"200932_s_at",0.812896635201594,0.361875863528828,-0.931022884199981,-5.5260903013067,-0.351810625418542,"DCTN2","dynactin subunit 2",TRUE
+"204246_s_at",0.65284137151906,0.121614777273867,-1.60972285747006,-4.75073894987501,-0.607981202033249,"DCTN3","dynactin subunit 3",TRUE
+"222488_s_at",0.571736836402345,0.059757273991704,-1.98419091263451,-4.18493180657317,-0.620131200644902,"DCTN4","dynactin subunit 4",TRUE
+"218013_x_at",0.755639383619058,0.249790764559925,-1.18186004060713,-5.28133514268063,-0.30517492863093,"DCTN4","dynactin subunit 4",TRUE
+"233490_at",0.784918343662568,0.309695853147026,-1.03969289838232,-5.42647043535258,-0.685624902197065,"DCTN4","dynactin subunit 4",TRUE
+"209232_s_at",0.274882222151803,0.004387771829394,-3.17195489073896,-1.9567257600837,-1.12260822216651,"DCTN5","dynactin subunit 5",TRUE
+"209231_s_at",0.378119110146051,0.0115826923487025,-2.75219389122799,-2.80080481306795,-0.824184962844054,"DCTN5","dynactin subunit 5",TRUE
+"1555900_at",0.769782310234542,0.277318741009415,-1.11376064685246,-5.3529118065604,-0.40979778252238,"DCTN5","dynactin subunit 5",TRUE
+"232343_at",0.812302873476553,0.358251272474622,-0.938211587486683,-5.51981051377746,-0.5414755731938,"DCTN5","dynactin subunit 5",TRUE
+"1556646_at",0.965354569120706,0.838406249925866,-0.206344397867238,-5.91896655399105,-0.0697581929993589,"DCTN5","dynactin subunit 5",TRUE
+"203261_at",0.985473275897641,0.929165667047083,0.0899111302504284,-5.93574682378284,0.0269137666207104,"DCTN6","dynactin subunit 6",TRUE
+"218069_at",0.51470556386048,0.035206960464601,-2.24318163902012,-3.74738150537472,-0.81008369950878,"DCTPP1","dCTP pyrophosphatase 1",TRUE
+"222678_s_at",0.630830446704781,0.102072255833427,1.70555779131556,-4.61422504569138,0.521348392787358,"DCUN1D1","defective in cullin neddylation 1 domain containing 1",TRUE
+"222679_s_at",0.783297012796639,0.305863469185301,1.04816247172143,-5.41828869048877,0.345321041247569,"DCUN1D1","defective in cullin neddylation 1 domain containing 1",TRUE
+"240781_x_at",0.847644062908097,0.446545572903714,-0.774977176062039,-5.65131709841887,-0.35017279147366,"DCUN1D1","defective in cullin neddylation 1 domain containing 1",TRUE
+"218583_s_at",0.87579870142401,0.52362912085114,0.648023206393709,-5.73719311089797,0.18721518142185,"DCUN1D1","defective in cullin neddylation 1 domain containing 1",TRUE
+"238879_at",0.895457620469779,0.574566881414189,0.569768461081112,-5.7827902546819,0.169638196127387,"DCUN1D1","defective in cullin neddylation 1 domain containing 1",TRUE
+"237408_at",0.943177611554239,0.744654388619091,-0.329792518963506,-5.8868473811393,-0.155228060240395,"DCUN1D1","defective in cullin neddylation 1 domain containing 1",TRUE
+"219116_s_at",0.852994610926182,0.459271426568446,0.75317858091172,-5.66709710294012,0.222703442790221,"DCUN1D2","defective in cullin neddylation 1 domain containing 2",TRUE
+"239648_at",0.663985642001593,0.132019897836293,-1.56386811687824,-4.8138966816741,-0.375999869609668,"DCUN1D3","defective in cullin neddylation 1 domain containing 3",TRUE
+"227333_at",0.851733415458562,0.45587198062173,-0.758965602202798,-5.66294937639259,-0.201820618847922,"DCUN1D3","defective in cullin neddylation 1 domain containing 3",TRUE
+"212855_at",0.606900628956089,0.0803711173000081,-1.83237412525799,-4.42458638583581,-0.64643562773748,"DCUN1D4","defective in cullin neddylation 1 domain containing 4",TRUE
+"212851_at",0.848268984089208,0.448022250837113,-0.772428608840803,-5.65318395676129,-0.248360364554678,"DCUN1D4","defective in cullin neddylation 1 domain containing 4",TRUE
+"212853_at",0.980009054680439,0.905921656258567,-0.119544052909123,-5.93272536459522,-0.0349865585571507,"DCUN1D4","defective in cullin neddylation 1 domain containing 4",TRUE
+"238479_at",0.778686132916778,0.299569150574576,1.06223773378742,-5.40455992554442,0.304551306831693,"DCUN1D5","defective in cullin neddylation 1 domain containing 5",TRUE
+"223151_at",0.91671872326659,0.647511607856412,0.463521733272935,-5.83557515176789,0.197403962357626,"DCUN1D5","defective in cullin neddylation 1 domain containing 5",TRUE
+"239425_at",0.929126743655924,0.688395241440343,-0.406333857012364,-5.85958424449858,-0.313894178580525,"DCUN1D5","defective in cullin neddylation 1 domain containing 5",TRUE
+"204850_s_at",0.832792886465252,0.409785956107143,-0.840173823094912,-5.60159649099759,-0.464245312739106,"DCX","doublecortin",TRUE
+"204851_s_at",0.988634593719643,0.945219657102892,0.0694941830187239,-5.93733151159762,0.0669318756238582,"DCX","doublecortin",TRUE
+"217973_at",0.319955762434047,0.00707123497625617,-2.96771291568969,-2.37311080055146,-1.92368569751287,"DCXR","dicarbonyl and L-xylulose reductase",TRUE
+"227472_at",0.862639573412331,0.486260996000952,-0.708108632090242,-5.69836853825782,-0.525419753313291,"DDA1","DET1 and DDB1 associated 1",TRUE
+"227457_at",0.870684240983489,0.509925235761671,0.66976933444782,-5.72352190642724,0.196174440015308,"DDA1","DET1 and DDB1 associated 1",TRUE
+"218260_at",0.899331416659389,0.590061182307907,0.546681613960609,-5.79515844950981,0.235582033897563,"DDA1","DET1 and DDB1 associated 1",TRUE
+"243711_at",0.874487622985108,0.520901927853297,-0.652325576056044,-5.7345226736357,-0.836951331033625,"DDAH1","dimethylarginine dimethylaminohydrolase 1",TRUE
+"1553565_s_at",0.932269331146744,0.701495683576166,0.388305792229638,-5.86650907995231,0.345461574878577,"DDAH1","dimethylarginine dimethylaminohydrolase 1",TRUE
+"209094_at",0.96287357728432,0.831253843982035,-0.21562346837067,-5.91706355857629,-0.114478585192543,"DDAH1","dimethylarginine dimethylaminohydrolase 1",TRUE
+"229456_s_at",0.965992617204023,0.840921398840475,-0.203085847713763,-5.91961505859198,-0.137775050548691,"DDAH1","dimethylarginine dimethylaminohydrolase 1",TRUE
+"202262_x_at",0.829519289742569,0.400888030632032,-0.856503636189082,-5.58855506701283,-0.476080019756356,"DDAH2","dimethylarginine dimethylaminohydrolase 2",TRUE
+"214909_s_at",0.884769004468037,0.544668088249435,-0.615234039419867,-5.75698652734459,-0.345353692007828,"DDAH2","dimethylarginine dimethylaminohydrolase 2",TRUE
+"215537_x_at",0.894400303187369,0.570869759150298,-0.575323321780574,-5.77974036618996,-0.369189560165664,"DDAH2","dimethylarginine dimethylaminohydrolase 2",TRUE
+"208619_at",0.67959860419143,0.146944941906741,-1.50305586736104,-4.89543045962524,-0.507761946262498,"DDB1","damage specific DNA binding protein 1",TRUE
+"203409_at",0.872283525329295,0.515297404382458,0.661206318066578,-5.72895687802767,0.524006339577504,"DDB2","damage specific DNA binding protein 2",TRUE
+"205311_at",0.812302873476553,0.357717654126181,-0.939274039821152,-5.51887863173176,-1.09570315705405,"DDC","dopa decarboxylase",TRUE
+"214347_s_at",0.878788356961452,0.532050802535424,-0.634814108886776,-5.7452857720813,-0.62674762098192,"DDC","dopa decarboxylase",TRUE
+"1564459_at",0.947326616179611,0.760502463983763,0.308608275461012,-5.89340220624201,0.229323708433335,"DDC-AS1","DDC antisense RNA 1",TRUE
+"225970_at",0.445869317136885,0.0208673560810703,-2.48752751686842,-3.30564637756673,-1.03655419578703,"DDHD1","DDHD domain containing 1",TRUE
+"243705_at",0.522403182336918,0.0382463776358522,-2.20352172363528,-3.81656028371038,-0.910709324340691,"DDHD1","DDHD domain containing 1",TRUE
+"225971_at",0.631316839203356,0.102514656978669,-1.7032228890191,-4.61762206040423,-0.891906596592737,"DDHD1","DDHD domain containing 1",TRUE
+"225965_at",0.877074739399942,0.526260144030605,-0.643884181142903,-5.73974614593542,-0.248473663308345,"DDHD1","DDHD domain containing 1",TRUE
+"244154_at",0.942303845415102,0.740476737563444,0.335402144955508,-5.88503955113742,0.111191332391327,"DDHD1","DDHD domain containing 1",TRUE
+"212690_at",0.952613441433926,0.782983314277718,-0.278800787240868,-5.90189487669628,-0.156861281290334,"DDHD2","DDHD domain containing 2",TRUE
+"239299_at",0.961395512423249,0.825054803496235,0.223681367474501,-5.91534341847777,0.121766655271134,"DDI1","DNA damage inducible 1 homolog 1",TRUE
+"224449_at",0.758920166935337,0.256166984256959,1.16561053881381,-5.29875306924123,0.354842279760136,"DDI2///RSC1A1","DNA damage inducible 1 homolog 2///regulatory solute carrier protein, family 1, member 1",TRUE
+"225780_at",0.76912869907427,0.274977128117738,-1.11935482027434,-5.34717326670911,-0.33337133408993,"DDI2///RSC1A1","DNA damage inducible 1 homolog 2///regulatory solute carrier protein, family 1, member 1",TRUE
+"214583_at",0.862639573412331,0.486157967503877,-0.708277859060613,-5.69825455311733,-0.18614038881106,"DDI2///RSC1A1","DNA damage inducible 1 homolog 2///regulatory solute carrier protein, family 1, member 1",TRUE
+"238519_at",0.969882914559333,0.856483687798981,0.182972316596367,-5.92339030125366,0.0773304270372712,"DDI2///RSC1A1","DNA damage inducible 1 homolog 2///regulatory solute carrier protein, family 1, member 1",TRUE
+"228281_at",0.7916581936323,0.322348616341342,1.01224375955167,-5.45257508314932,0.566047664869242,"DDIAS","DNA damage induced apoptosis suppressor",TRUE
+"209383_at",0.789503009592599,0.316660948249615,1.02448740280129,-5.44100906314607,0.3536972274426,"DDIT3","DNA damage inducible transcript 3",TRUE
+"202887_s_at",0.760486759210509,0.259601735233744,1.15698147338885,-5.30791672262937,1.01601887288288,"DDIT4","DNA damage inducible transcript 4",TRUE
+"228057_at",0.148930223762869,0.00104870848008604,3.76856726935508,-0.698514221964283,1.78203372074959,"DDIT4L","DNA damage inducible transcript 4 like",TRUE
+"214788_x_at",0.894538680437601,0.571025626868367,0.57508876502793,-5.77986972886631,0.252119750624298,"DDN","dendrin",TRUE
+"207418_s_at",0.514490373584066,0.0347010140957554,2.25008440718466,-3.73526514096808,1.19096648845464,"DDO","D-aspartate oxidase",TRUE
+"222134_at",0.724317760087277,0.201591467900524,1.3161099954125,-5.12949550014579,1.34193654515526,"DDO","D-aspartate oxidase",TRUE
+"208675_s_at",0.768852835478002,0.273052114479176,1.12397981558263,-5.3424096988285,0.35524189416323,"DDOST","dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit",TRUE
+"208674_x_at",0.955816406528307,0.798708162174398,0.258105032435199,-5.90728819640589,0.08168939424041,"DDOST","dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit",TRUE
+"216459_x_at",0.948668195792872,0.766335939409341,0.300847287632728,-5.89569573415649,0.139529915564085,"DDR1-AS1","DDR1 antisense RNA 1 (head to head)",TRUE
+"216679_at",0.986418104647939,0.93598197039309,-0.0812381072648617,-5.93646955541395,-0.0545334545396399,"DDR1-AS1","DDR1 antisense RNA 1 (head to head)",TRUE
+"225442_at",0.493378740589161,0.0297647577141376,-2.32273349008406,-3.60641677621518,-1.98710271260295,"DDR2","discoidin domain receptor tyrosine kinase 2",TRUE
+"235631_at",0.591331966259927,0.068709167721026,-1.91336924024283,-4.29837843823522,-1.06669209791361,"DDR2","discoidin domain receptor tyrosine kinase 2",TRUE
+"205168_at",0.663819586595936,0.131819069910459,-1.56472426373134,-4.81273056902507,-1.43504160011077,"DDR2","discoidin domain receptor tyrosine kinase 2",TRUE
+"227561_at",0.71454754703986,0.189505411883886,-1.3536223302011,-5.08459392453987,-0.68360851078248,"DDR2","discoidin domain receptor tyrosine kinase 2",TRUE
+"218159_at",0.943824539742785,0.748402717005005,-0.32476855012199,-5.88844085582995,-0.12948821938463,"DDRGK1","DDRGK domain containing 1",TRUE
+"202929_s_at",0.556381379241158,0.0517423178982277,-2.05608650480372,-4.06693779693961,-0.63630269206165,"DDTL///DDT","D-dopachrome tautomerase-like///D-dopachrome tautomerase",TRUE
+"201241_at",0.831013183269159,0.404979741541742,-0.848965915549362,-5.59460398451475,-0.263631541754739,"DDX1","DEAD/H-box helicase 1",TRUE
+"1563522_at",0.8920930097751,0.564173151321076,-0.585431757277063,-5.77411684562471,-0.446607798871532,"DDX10","DEAD-box helicase 10",TRUE
+"204977_at",0.911393258378799,0.629561137205139,0.489123638965075,-5.82382458218375,0.202382728634369,"DDX10","DEAD-box helicase 10",TRUE
+"232816_s_at",0.517859245504688,0.03694436754337,2.22014668453178,-3.78765236721173,0.682024242859919,"DDX11","DEAD/H-box helicase 11",TRUE
+"210206_s_at",0.610033432202476,0.0823435418924904,1.81970093330576,-4.44398224929155,0.728699691765538,"DDX11","DEAD/H-box helicase 11",TRUE
+"208159_x_at",0.733945983292434,0.218078902588707,1.26766352963902,-5.18590271179212,0.369805205176901,"DDX11","DEAD/H-box helicase 11",TRUE
+"208149_x_at",0.73759219552868,0.224284950166711,1.25015829047618,-5.20584006779312,0.360821458224347,"DDX11","DEAD/H-box helicase 11",TRUE
+"1557139_at",0.304824368772306,0.00602602335365207,3.03657380206157,-2.23381312859399,1.72795498632993,"DDX11-AS1","DDX11 antisense RNA 1",TRUE
+"223777_at",0.734614760371776,0.219219766909202,1.2644171319931,-5.18961808181529,0.907208321454543,"DDX11L2","DEAD/H-box helicase 11 like 2",TRUE
+"230180_at",0.6708432030569,0.136402518287725,1.54544759645244,-4.83886442384749,1.12207916533235,"DDX17","DEAD-box helicase 17",TRUE
+"213998_s_at",0.834605807358697,0.413127966535999,0.834098807589992,-5.6063883373413,0.663608012439704,"DDX17","DEAD-box helicase 17",TRUE
+"208719_s_at",0.8920930097751,0.564047702348242,0.585621706224953,-5.77401026604573,0.648609390534864,"DDX17","DEAD-box helicase 17",TRUE
+"208151_x_at",0.937113154905832,0.720814073101783,0.361956058942376,-5.87607295338715,0.280883658331577,"DDX17","DEAD-box helicase 17",TRUE
+"208718_at",0.998709719538178,0.994301839703892,0.00722265913263301,-5.93965807225372,0.00194192956582917,"DDX17","DEAD-box helicase 17",TRUE
+"208896_at",0.924931811669372,0.675187534839469,-0.424649318896893,-5.85223245359356,-0.148800817818179,"DDX18","DEAD-box helicase 18",TRUE
+"208895_s_at",0.952293443370532,0.781692826321716,-0.280504631347568,-5.90143246396062,-0.0813632421715358,"DDX18","DEAD-box helicase 18",TRUE
+"208897_s_at",0.958931830316768,0.81407567229617,0.237990343277225,-5.91213410703695,0.0779844553152653,"DDX18","DEAD-box helicase 18",TRUE
+"205763_s_at",0.989669132517581,0.950498688937005,0.0627875221231019,-5.93776352735678,0.0207477747571723,"DDX18","DEAD-box helicase 18",TRUE
+"202578_s_at",0.936599157163462,0.717019158769012,-0.36711105951007,-5.8742540587667,-0.118724643333854,"DDX19A","DEAD-box helicase 19A",TRUE
+"1570128_at",0.953931868692178,0.78738730473325,0.272992462694348,-5.90345020308015,0.0971086092335014,"DDX19A","DEAD-box helicase 19A",TRUE
+"202577_s_at",0.984132887597385,0.922061312149921,-0.0989582050674422,-5.93491493010864,-0.0331865095609238,"DDX19A","DEAD-box helicase 19A",TRUE
+"202576_s_at",0.954337260876625,0.789808993459651,-0.269802647764446,-5.90429052790894,-0.096374067342806,"DDX19A///DDX19B","DEAD-box helicase 19A///DEAD-box helicase 19B",TRUE
+"230974_at",0.955904644595647,0.800577996751843,0.255651933614137,-5.90790009386756,0.231582360291526,"DDX19B","DEAD-box helicase 19B",TRUE
+"224315_at",0.470885186348082,0.0254551258776099,-2.39585527442427,-3.47436524597691,-0.868484134558377,"DDX20","DEAD-box helicase 20",TRUE
+"223331_s_at",0.575270671804438,0.0608340318167056,-1.97519478442678,-4.19949802502516,-0.667775660156336,"DDX20","DEAD-box helicase 20",TRUE
+"208152_s_at",0.868039927215454,0.501804078271584,0.682810602849953,-5.71511599190769,0.245882842503869,"DDX21","DEAD-box helicase 21",TRUE
+"224654_at",0.906507435035949,0.614141062593877,0.511383775567867,-5.81310642749162,0.180586130702299,"DDX21","DEAD-box helicase 21",TRUE
+"201440_at",0.370281512376054,0.0111473867283216,-2.76910856243774,-2.76773215816703,-0.9350361844169,"DDX23","DEAD-box helicase 23",TRUE
+"40465_at",0.451974019443452,0.0216958332583197,-2.46967051752967,-3.33877785894926,-0.761443112380537,"DDX23","DEAD-box helicase 23",TRUE
+"200694_s_at",0.689671882692226,0.158570923407846,-1.4590969523252,-4.95275246404819,-0.436433835781392,"DDX24","DEAD-box helicase 24",TRUE
+"200702_s_at",0.840041055449124,0.428937784373133,-0.805772117598676,-5.62830179158349,-0.431766213929524,"DDX24","DEAD-box helicase 24",TRUE
+"219945_at",0.942502815705589,0.741968336386738,0.333398019749288,-5.88568888976382,0.25894580942946,"DDX25","DEAD-box helicase 25",TRUE
+"221780_s_at",0.812302873476553,0.360765058861628,-0.933220804893838,-5.52417498911783,-0.300669071933202,"DDX27","DEAD-box helicase 27",TRUE
+"215693_x_at",0.999728735068188,0.999344751466241,-0.000830547777656421,-5.93968314476828,-0.000286004512522808,"DDX27","DEAD-box helicase 27",TRUE
+"219108_x_at",0.868301026121579,0.502479094037252,-0.68172212564633,-5.7158235134007,-0.213328786224599,"DDX27///SS18","DEAD-box helicase 27///SS18, nBAF chromatin remodeling complex subunit",TRUE
+"214025_at",0.615637099066718,0.0859096941146213,1.79744045556408,-4.47781589036867,1.06396376937047,"DDX28","DEAD-box helicase 28",TRUE
+"40255_at",0.630830446704781,0.102070818766082,-1.70556538987117,-4.61421398496497,-0.567285191246162,"DDX28","DEAD-box helicase 28",TRUE
+"203785_s_at",0.724623760403195,0.201957078643571,-1.31500294337582,-5.13080447323185,-0.423611203716359,"DDX28","DEAD-box helicase 28",TRUE
+"203784_s_at",0.930578279104258,0.69285744098356,0.400178142061835,-5.86198353106654,0.177040683695389,"DDX28","DEAD-box helicase 28",TRUE
+"1553181_at",0.68806049531767,0.15741779232766,1.46333784258563,-4.94728233528195,0.462684224721931,"DDX31","DEAD-box helicase 31",TRUE
+"235436_at",0.771855357662161,0.28197908653062,-1.102728424412,-5.36415398222168,-0.357302738198829,"DDX31","DEAD-box helicase 31",TRUE
+"219328_at",0.822173415758858,0.386509228139535,-0.883392438647814,-5.56657224706114,-0.437170497312213,"DDX31","DEAD-box helicase 31",TRUE
+"201584_s_at",0.859064198633089,0.475506523787326,0.725886831668139,-5.68625213437734,0.238526374858484,"DDX39A","DEAD-box helicase 39A",TRUE
+"212515_s_at",0.606900628956089,0.0803445408222785,-1.83254671787597,-4.42432157258931,-0.575685356392555,"DDX3X","DEAD-box helicase 3, X-linked",TRUE
+"207617_at",0.774230543658252,0.289528800920695,1.08513331422488,-5.38187792603808,0.85437817889343,"DDX3X","DEAD-box helicase 3, X-linked",TRUE
+"201210_at",0.853093296743962,0.45954189259959,-0.752719259546201,-5.66742502488725,-0.168902626772153,"DDX3X","DEAD-box helicase 3, X-linked",TRUE
+"212514_x_at",0.895195476627048,0.572756123997595,-0.572486818735639,-5.78130132609511,-0.226222759808499,"DDX3X","DEAD-box helicase 3, X-linked",TRUE
+"201211_s_at",0.90360437116293,0.604853927917586,-0.524917188876061,-5.80636286543079,-0.229138368961381,"DDX3X","DEAD-box helicase 3, X-linked",TRUE
+"1558120_at",0.987512421689914,0.941256924443496,-0.0745307026072817,-5.93697829211558,-0.0429893490250537,"DDX3X","DEAD-box helicase 3, X-linked",TRUE
+"1570359_at",0.299994279961527,0.00558074099907326,-3.06947170504268,-2.16685919657412,-1.67108639747673,"DDX3Y","DEAD-box helicase 3, Y-linked",TRUE
+"205001_s_at",0.642592458809121,0.112804051118993,1.65118962194325,-4.69241037468875,0.960093997836053,"DDX3Y","DEAD-box helicase 3, Y-linked",TRUE
+"205000_at",0.79943091106207,0.334364628699907,0.986863305093789,-5.47614914690509,0.733079125601796,"DDX3Y","DEAD-box helicase 3, Y-linked",TRUE
+"1570360_s_at",0.834454640870101,0.412768314082606,-0.834751074462418,-5.60587540010161,-0.595845192264282,"DDX3Y","DEAD-box helicase 3, Y-linked",TRUE
+"221630_s_at",0.951934441578502,0.779943574875579,0.282815541152836,-5.90080082969477,0.160761256954641,"DDX4","DEAD-box helicase 4",TRUE
+"217840_at",0.606032418428309,0.0795350909285516,-1.83782732866817,-4.41621076862589,-0.541786248761399,"DDX41","DEAD-box helicase 41",TRUE
+"201788_at",0.85334340854827,0.460397390953507,-0.751267465942662,-5.6684602542826,-0.232161058963623,"DDX42","DEAD-box helicase 42",TRUE
+"1559954_s_at",0.94895689004559,0.769091891243537,-0.29718728644997,-5.89675724548727,-0.0927383350841513,"DDX42","DEAD-box helicase 42",TRUE
+"1559953_at",0.977874971442423,0.892767193890114,0.136361150509852,-5.93063090805763,0.0814822840616101,"DDX42","DEAD-box helicase 42",TRUE
+"220004_at",0.890946678837957,0.560135366042541,0.591556558067241,-5.77066340144963,0.857786404958305,"DDX43","DEAD-box helicase 43",TRUE
+"228039_at",0.769429807058463,0.276910832359237,-1.11473266884011,-5.35191652861096,-0.393699650821729,"DDX46","DEAD-box helicase 46",TRUE
+"202462_s_at",0.889389445320988,0.557186032146937,-0.596044778912706,-5.76811067725238,-0.156195589829927,"DDX46","DEAD-box helicase 46",TRUE
+"232915_at",0.712948021516228,0.187172490184617,1.36107838869789,-5.07554326975827,1.02068776267256,"DDX49","DEAD-box helicase 49",TRUE
+"31807_at",0.819018525257656,0.374621383919628,-0.906119797550624,-5.54750068992273,-0.331398934507583,"DDX49","DEAD-box helicase 49",TRUE
+"210811_s_at",0.863977501644799,0.490416858958323,-0.70129968947714,-5.70293325897731,-0.243926100385686,"DDX49","DEAD-box helicase 49",TRUE
+"225886_at",0.937113154905832,0.719918869801836,-0.363171194913943,-5.87564649136685,-0.194871976033081,"DDX5","DEAD-box helicase 5",TRUE
+"1568814_at",0.719333457476224,0.195188465173006,1.33575688570578,-5.1061107534058,0.675019879577795,"DDX50","DEAD-box helicase 50",TRUE
+"1568815_a_at",0.760227035076299,0.257971693717231,1.16106597990384,-5.30358661629437,1.02516719776429,"DDX50","DEAD-box helicase 50",TRUE
+"221699_s_at",0.942303845415102,0.740855247373198,0.334893443546346,-5.88520473549084,0.119946934928706,"DDX50","DEAD-box helicase 50",TRUE
+"1554085_at",0.689061143661902,0.158052415229335,-1.4610007798652,-4.95029839777484,-0.409543812963191,"DDX51","DEAD-box helicase 51",TRUE
+"214968_at",0.915939421175188,0.645272197773367,-0.466698235371739,-5.8341508160219,-0.2796235955017,"DDX51","DEAD-box helicase 51",TRUE
+"229482_at",0.937655803006818,0.72428839475088,0.357245300976159,-5.87771288969854,0.116733705974688,"DDX51","DEAD-box helicase 51",TRUE
+"210320_s_at",0.863230457544525,0.487309092002399,0.706388283259156,-5.69952582985836,0.345816252345909,"DDX52","DEAD-box helicase 52",TRUE
+"212834_at",0.928167838756364,0.68430627490204,0.411988741319062,-5.85734840120884,0.205699674342325,"DDX52","DEAD-box helicase 52",TRUE
+"1570415_at",0.94707540313757,0.759877526928924,-0.309440845668681,-5.89315272714265,-0.333275654880953,"DDX52","DEAD-box helicase 52",TRUE
+"213637_at",0.960614707352139,0.821031068529247,0.228919752151064,-5.91419148529737,0.141795824470666,"DDX52","DEAD-box helicase 52",TRUE
+"1555357_at",0.637485146909712,0.108631613328277,1.67178510805291,-4.66301849485061,1.91912475222397,"DDX53","DEAD-box helicase 53",TRUE
+"225428_s_at",0.683019114815084,0.151961063894518,-1.48375457636328,-4.92076805949316,-0.406623317420546,"DDX54","DEAD-box helicase 54",TRUE
+"224433_s_at",0.756313947022433,0.25142097100803,-1.17767640129735,-5.28583975616716,-0.334280950093651,"DDX54","DEAD-box helicase 54",TRUE
+"219111_s_at",0.941423824490503,0.738158927405722,-0.338519160279685,-5.88402198581725,-0.104955083201755,"DDX54","DEAD-box helicase 54",TRUE
+"231843_at",0.790309297261437,0.319914354711088,-1.01746526854476,-5.44765793693025,-0.298016369287202,"DDX55","DEAD-box helicase 55",TRUE
+"217754_at",0.722288531465626,0.198669442206939,-1.32501448415317,-5.1189330813252,-0.357178554653409,"DDX56","DEAD-box helicase 56",TRUE
+"238525_at",0.888365275629554,0.554466667231066,0.600194009119685,-5.76573417477196,0.249216896491514,"DDX56","DEAD-box helicase 56",TRUE
+"218943_s_at",0.411110107932987,0.0160358201541443,2.60710402815246,-3.08063955114582,1.60555329367966,"DDX58","DEXD/H-box helicase 58",TRUE
+"222793_at",0.671016283173618,0.136961683010083,1.54313266864397,-4.84198561910183,0.69353483826516,"DDX58","DEXD/H-box helicase 58",TRUE
+"242961_x_at",0.828607509614823,0.398837256015838,0.860300134800418,-5.5854895700975,0.678944842705217,"DDX58","DEXD/H-box helicase 58",TRUE
+"228385_at",0.351113781122892,0.00928597215370283,-2.84933310177434,-2.60968311529649,-1.11523445497865,"DDX59","DEAD-box helicase 59",TRUE
+"228386_s_at",0.605913415325856,0.0794177563438804,-1.83859665370866,-4.41502772349626,-0.570358909197967,"DDX59","DEAD-box helicase 59",TRUE
+"223662_x_at",0.883409997508396,0.541372389145246,0.620324812520018,-5.75397832300187,0.191150633262778,"DDX59","DEAD-box helicase 59",TRUE
+"225549_at",0.789927874973432,0.319100964520705,1.0192161821132,-5.44600396137209,0.493193768063305,"DDX6","DEAD-box helicase 6",TRUE
+"204909_at",0.855405088766616,0.468356743485635,0.737836734263731,-5.67794748139589,0.309171358963023,"DDX6","DEAD-box helicase 6",TRUE
+"1562836_at",0.970740692577908,0.860643517732447,-0.177609337683795,-5.9243307061483,-0.144750606010234,"DDX6","DEAD-box helicase 6",TRUE
+"218986_s_at",0.499269687948253,0.0314495788396373,2.29677278392031,-3.65273509487119,2.27653036746155,"DDX60","DEXD/H-box helicase 60",TRUE
+"228152_s_at",0.369429132228615,0.0109813242533086,2.77572678159322,-2.75476749594378,3.14669430881401,"DDX60L","DEAD-box helicase 60-like",TRUE
+"1559585_at",0.823074246722209,0.389383397335272,0.87796643600275,-5.57105907030354,0.611575347097301,"DDX60L","DEAD-box helicase 60-like",TRUE
+"230059_at",0.600637035974564,0.0766337848396971,1.85714656796241,-4.38639542652243,0.811667303693518,"DEAF1","DEAF1, transcription factor",TRUE
+"209407_s_at",0.900646880891906,0.595680735624826,-0.538382697284061,-5.79948297659348,-0.271552146704671,"DEAF1","DEAF1, transcription factor",TRUE
+"220781_at",0.863488263044072,0.488214829940009,-0.704903320955322,-5.70052261805709,-0.399210730256066,"DEC1","deleted in esophageal cancer 1",TRUE
+"202447_at",0.768852835478002,0.273098562992138,-1.12386793942584,-5.34252513205424,-0.601205337230342,"DECR1","2,4-dienoyl-CoA reductase 1, mitochondrial",TRUE
+"219664_s_at",0.728385463227073,0.209760328252465,-1.29173839688774,-5.15809652704806,-0.708438390427686,"DECR2","2,4-dienoyl-CoA reductase 2, peroxisomal",TRUE
+"202480_s_at",0.508488499910913,0.0335007865318339,-2.26683412414043,-3.70577232069404,-0.786481654720291,"DEDD","death effector domain containing",TRUE
+"215158_s_at",0.556381379241158,0.0518167972983122,-2.05537397526094,-4.06812077981812,-0.709606715199863,"DEDD","death effector domain containing",TRUE
+"211255_x_at",0.619415519928971,0.0896186514682607,-1.77511936545376,-4.51143762388954,-0.57568602331965,"DEDD","death effector domain containing",TRUE
+"225434_at",0.883952384679702,0.542423076456802,-0.618700057854708,-5.7549410073768,-0.2113299534824,"DEDD2","death effector domain containing 2",TRUE
+"221293_s_at",0.647901037680949,0.119270671134134,1.62050265590178,-4.73568570228998,0.448824635867984,"DEF6","DEF6, guanine nucleotide exchange factor",TRUE
+"226659_at",0.728523962638265,0.209931697557514,1.29123506390559,-5.15868242775653,0.486183246232796,"DEF6","DEF6, guanine nucleotide exchange factor",TRUE
+"225637_at",0.877861946695164,0.52937651427401,-0.638996216946399,-5.74274089887811,-0.237409166645611,"DEF8","differentially expressed in FDCP 8 homolog",TRUE
+"219646_at",0.981587171772385,0.912571243911609,-0.11105672961164,-5.93367802518222,-0.0519063820943391,"DEF8","differentially expressed in FDCP 8 homolog",TRUE
+"205033_s_at",0.627592083375654,0.0991160916141974,1.7213847184172,-4.59110686585162,0.554543013363131,"DEFA1B///DEFA3///DEFA1","defensin alpha 1B///defensin alpha 3///defensin alpha 1",TRUE
+"207269_at",0.878647293269438,0.531596766399761,-0.635523335406102,-5.74485532898941,-0.363655155409416,"DEFA4","defensin alpha 4",TRUE
+"207529_at",0.8920930097751,0.564255267243383,0.585307432972833,-5.77418658537295,0.182723893623528,"DEFA5","defensin alpha 5",TRUE
+"207814_at",0.995025131654789,0.976739946072438,0.0294872994467032,-5.93925998782752,0.0117671749779915,"DEFA6","defensin alpha 6",TRUE
+"210397_at",0.51470556386048,0.03504130390864,2.24543172104539,-3.7434344055486,1.49295919935892,"DEFB1","defensin beta 1",TRUE
+"224239_at",0.791988150120355,0.322773157638707,1.0113359355996,-5.45342765301455,0.699506696080529,"DEFB103A///DEFB103B","defensin beta 103A///defensin beta 103B",TRUE
+"1553521_at",0.921294973929502,0.664357281709849,0.439778611956721,-5.84591944284497,0.347897289229534,"DEFB104B///DEFB104A","defensin beta 104B///defensin beta 104A",TRUE
+"1553002_at",0.765116907435848,0.265058607110058,1.14344430078153,-5.32217198553708,0.937983689035039,"DEFB105B///DEFB105A","defensin beta 105B///defensin beta 105A",TRUE
+"1552411_at",0.42796179417767,0.0184787225801827,2.54297859807408,-3.20197218142224,0.857729333426071,"DEFB106B///DEFB106A","defensin beta 106B///defensin beta 106A",TRUE
+"1552412_a_at",0.859675188316647,0.47784367549568,0.72200351219271,-5.68892313158146,0.555958227103665,"DEFB106B///DEFB106A","defensin beta 106B///defensin beta 106A",TRUE
+"1563450_at",0.722937902375896,0.199603846585978,1.32215595737873,-5.12233038368089,0.597399865493182,"DEFB107B///DEFB107A","defensin beta 107B///defensin beta 107A",TRUE
+"1561165_a_at",0.909441642299191,0.623910671554132,0.497250899422297,-5.81996530890938,0.270727472740325,"DEFB108B","defensin beta 108B",TRUE
+"1567878_at",0.858226066210126,0.473878464040475,0.728598567052222,-5.68437889460172,0.756516007701336,"DEFB114","defensin beta 114",TRUE
+"233221_at",0.963112917160969,0.832249344018055,0.214330829162001,-5.91733365473611,0.0769090788230322,"DEFB118","defensin beta 118",TRUE
+"231155_at",0.879698016525632,0.534339009359731,-0.631244791148526,-5.7474450402084,-0.359584956763774,"DEFB119","defensin beta 119",TRUE
+"1553093_a_at",0.918409982899324,0.65374665065311,-0.454702924508858,-5.83947952286689,-0.367688450010895,"DEFB119","defensin beta 119",TRUE
+"234007_at",0.780039345808573,0.301358410635839,1.05821539110223,-5.40850001644804,0.475387398935233,"DEFB121","defensin beta 121",TRUE
+"1562167_a_at",0.591331966259927,0.0688384069796485,1.91240776498253,-4.29989904338192,1.34041461359938,"DEFB122","defensin beta 122 (pseudogene)",TRUE
+"229772_at",0.928875638460009,0.686832817771582,-0.408493028156214,-5.85873413412395,-0.30618084328611,"DEFB123","defensin beta 123",TRUE
+"1568375_at",0.835952408568777,0.415941027619891,0.829009378244145,-5.61037774446021,0.317710014887738,"DEFB124","defensin beta 124",TRUE
+"1568377_x_at",0.976422537443518,0.887992419316715,-0.142475093941692,-5.92980134578363,-0.0898126396057499,"DEFB124","defensin beta 124",TRUE
+"1552998_at",0.90344422113846,0.604526873897587,0.525395578121632,-5.80612134946911,0.37006019078849,"DEFB125","defensin beta 125",TRUE
+"221414_s_at",0.882420879090034,0.54002792472555,0.622406313366453,-5.75274145742077,0.411932594017688,"DEFB126","defensin beta 126",TRUE
+"233166_at",0.901788521024914,0.599424913295081,-0.53287451572703,-5.80231774671018,-0.4265845504595,"DEFB126","defensin beta 126",TRUE
+"233343_at",0.596382916302699,0.0728964244885361,1.8829949089086,-4.34615859641351,1.01603923260851,"DEFB127","defensin beta 127",TRUE
+"233160_at",0.950214160603623,0.773917191531956,-0.290789050269618,-5.89858197830839,-0.22410918056462,"DEFB129","defensin beta 129",TRUE
+"243311_at",0.97345342693821,0.871771180506147,0.163288929946565,-5.92670512091797,0.139938956344487,"DEFB132","defensin beta 132",TRUE
+"207356_at",0.552420073963858,0.049938308064122,2.0736315711652,-4.03772416187087,0.928227119573324,"DEFB4B///DEFB4A","defensin beta 4B///defensin beta 4A",TRUE
+"1553518_at",0.927305853101946,0.681839047213616,0.415407432654586,-5.85598196611018,0.269742936961525,"DEFT1P2///DEFT1P","defensin, theta 1 pseudogene 2///defensin, theta 1 pseudogene",TRUE
+"209250_at",0.810602600845179,0.354745519178982,-0.945211270474676,-5.51365324356854,-0.568205282236107,"DEGS1","delta 4-desaturase, sphingolipid 1",TRUE
+"207431_s_at",0.866546454834464,0.497580721527718,-0.689639768728859,-5.71065235119735,-0.334353979898784,"DEGS1","delta 4-desaturase, sphingolipid 1",TRUE
+"236496_at",0.48580305784244,0.028564684559952,-2.34206108970752,-3.5717385385575,-3.85937728412954,"DEGS2","delta 4-desaturase, sphingolipid 2",TRUE
+"200934_at",0.656693876264681,0.124797316318851,1.59536183126942,-4.77067204102901,0.517067648848528,"DEK","DEK proto-oncogene",TRUE
+"226849_at",0.612280302313181,0.0838770821092954,-1.81002812950549,-4.45872089209682,-0.562590081656179,"DENND1A","DENN domain containing 1A",TRUE
+"219763_at",0.92563477467988,0.678490714193894,-0.420055095219929,-5.85410650768519,-0.171964909602444,"DENND1A","DENN domain containing 1A",TRUE
+"1552835_at",0.819578123838368,0.376908501980648,0.901710793804897,-5.55123550999289,0.605138216473415,"DENND1B","DENN domain containing 1B",TRUE
+"238787_at",0.886782011834068,0.549839985235162,-0.60727799129936,-5.76163998421027,-0.466642300490711,"DENND1B","DENN domain containing 1B",TRUE
+"228032_s_at",0.888830748858811,0.555965255002404,-0.597906141306509,-5.76704653783558,-0.441009659250916,"DENND1B","DENN domain containing 1B",TRUE
+"1557309_at",0.898111726390495,0.587097466247236,0.551074060799414,-5.79284355593565,0.298522289987683,"DENND1B","DENN domain containing 1B",TRUE
+"219696_at",0.95877806139143,0.813326265173849,-0.238968856941574,-5.91190741079526,-0.191182856157686,"DENND1B","DENN domain containing 1B",TRUE
+"1564164_at",0.982844899319041,0.916597212050533,-0.105922210282492,-5.93422034587983,-0.0732111500972339,"DENND1B","DENN domain containing 1B",TRUE
+"221080_s_at",0.817815704063733,0.37040820777316,0.914288594054953,-5.54053655153941,0.2412581039817,"DENND1C","DENN domain containing 1C",TRUE
+"53991_at",0.493519901382617,0.0298303616745107,2.32169768048099,-3.6082706012249,1.93866600891606,"DENND2A","DENN domain containing 2A",TRUE
+"221885_at",0.666643938027574,0.13334347182937,1.55825241251805,-4.82153308668752,1.5389008151183,"DENND2A","DENN domain containing 2A",TRUE
+"221886_at",0.986889306520757,0.938981180764334,-0.07742399224033,-5.93676421491066,-0.0601187167646833,"DENND2A","DENN domain containing 2A",TRUE
+"230769_at",0.655745626967443,0.124223271814243,1.59792941538432,-4.76711842825241,0.784009511619438,"DENND2C","DENN domain containing 2C",TRUE
+"233294_at",0.926606760676053,0.680647109689468,0.41706083291292,-5.85531712539944,0.156861105503812,"DENND2C","DENN domain containing 2C",TRUE
+"221081_s_at",0.848475456105025,0.44880465027314,-0.771080349746082,-5.65416922632619,-0.651685536574627,"DENND2D","DENN domain containing 2D",TRUE
+"238524_at",0.92265243752289,0.669487498908353,-0.432599182575414,-5.84894226683921,-0.363094829723397,"DENND2D","DENN domain containing 2D",TRUE
+"212975_at",0.425750271450885,0.0181123938069457,2.55206922912809,-3.18486404923762,1.69051335506168,"DENND3","DENN domain containing 3",TRUE
+"212974_at",0.468732760220321,0.0248013672683116,2.40793332979806,-3.45233343069708,0.991785400041408,"DENND3","DENN domain containing 3",TRUE
+"214787_at",0.429960090499345,0.0190129601059286,-2.53001866240357,-3.22630830121301,-0.78234812972165,"DENND4A","DENN domain containing 4A",TRUE
+"1554352_s_at",0.94895689004559,0.76797767258437,-0.29866650624754,-5.89632977792294,-0.0891156160333502,"DENND4A","DENN domain containing 4A",TRUE
+"202860_at",0.620223198657182,0.0900368822466345,-1.7726525528001,-4.51513449066674,-0.626858610344376,"DENND4B","DENN domain containing 4B",TRUE
+"234968_at",0.840420186487148,0.42956346651248,-0.804664606809834,-5.62914413254065,-0.386736446115563,"DENND4C","DENN domain containing 4C",TRUE
+"226867_at",0.969882914559333,0.85624266423726,-0.18328321831755,-5.92333492914202,-0.0702171197933303,"DENND4C","DENN domain containing 4C",TRUE
+"205684_s_at",0.988765741729843,0.945923747360241,-0.0685995009986314,-5.93739167439088,-0.033016988950628,"DENND4C","DENN domain containing 4C",TRUE
+"212561_at",0.942684843065067,0.743309324849636,-0.331597444142979,-5.88626899461494,-0.160143188038182,"DENND5A","DENN domain containing 5A",TRUE
+"236415_at",0.698624954290265,0.169893322217528,1.4187253604055,-5.00417723390431,0.822633609236396,"DENND5B","DENN domain containing 5B",TRUE
+"238917_s_at",0.870433264908839,0.508853822128081,0.671483137807145,-5.72242610660084,0.280444226467362,"DENND5B","DENN domain containing 5B",TRUE
+"243613_at",0.914966942918905,0.641876129322565,0.471524734814143,-5.83196839624272,0.413708951575234,"DENND5B","DENN domain containing 5B",TRUE
+"228551_at",0.976422537443518,0.8879147897419,-0.142574541395548,-5.92978755228658,-0.133549571155797,"DENND5B","DENN domain containing 5B",TRUE
+"215058_at",0.981055483128003,0.910670216382927,0.11348226023025,-5.93341291892548,0.1151097709237,"DENND5B","DENN domain containing 5B",TRUE
+"226965_at",0.930908124163614,0.694594044844464,-0.397786714007912,-5.86290590138183,-0.120042324062313,"DENND6A","DENN domain containing 6A",TRUE
+"228678_at",0.677509122383198,0.145018519003014,-1.51061161274678,-4.88544023495905,-1.44376739994537,"DENND6B","DENN domain containing 6B",TRUE
+"220713_at",0.821137675198948,0.382041303485912,0.891879752800878,-5.55950261384209,0.285465415555371,"DENND6B","DENN domain containing 6B",TRUE
+"229739_s_at",0.920295529438727,0.660756251761716,0.444832079087483,-5.8437624508674,0.290843310957943,"DENND6B","DENN domain containing 6B",TRUE
+"234347_s_at",0.579119470758542,0.0622991734814951,1.96317747392946,-4.21888604005965,0.662083399525396,"DENR","density regulated re-initiation and release factor",TRUE
+"238982_at",0.783844746433788,0.306438555459301,1.04688675945302,-5.41952486783019,0.501478664975626,"DENR","density regulated re-initiation and release factor",TRUE
+"234915_s_at",0.961212424803935,0.823188932743985,0.226109685992563,-5.91481272457871,0.0632384601965761,"DENR","density regulated re-initiation and release factor",TRUE
+"221509_at",0.971216837324271,0.862801701344882,0.174829051116916,-5.92480725605335,0.0467770655951387,"DENR","density regulated re-initiation and release factor",TRUE
+"231896_s_at",0.990810941805126,0.956738083374624,-0.0548645628003566,-5.93821746850243,-0.0150497590816059,"DENR","density regulated re-initiation and release factor",TRUE
+"220295_x_at",0.632949074657601,0.103886665096277,1.69603576875182,-4.62805654312349,0.764367527976653,"DEPDC1","DEP domain containing 1",TRUE
+"222958_s_at",0.699391325858549,0.170931625599831,1.41513244289101,-5.00869656941041,0.58002885069129,"DEPDC1","DEP domain containing 1",TRUE
+"232278_s_at",0.769258076576208,0.276427862829461,1.11588490577109,-5.35073572744489,0.523900042196805,"DEPDC1","DEP domain containing 1",TRUE
+"235545_at",0.862639573412331,0.486070024588322,0.708422323973841,-5.6981572262689,0.311062525896675,"DEPDC1","DEP domain containing 1",TRUE
+"1569958_at",0.97897951922649,0.897930585962815,-0.129755572594502,-5.93148636381131,-0.101333375969753,"DEPDC1-AS1","DEPDC1 antisense RNA 1",TRUE
+"226980_at",0.877740599174557,0.528532886426344,0.640317879668758,-5.74193330735348,0.237481097106977,"DEPDC1B","DEP domain containing 1B",TRUE
+"1561114_a_at",0.657015752622694,0.125388600903235,-1.59272740358503,-4.77431354271225,-0.890536514286055,"DEPDC4","DEP domain containing 4",TRUE
+"1553365_at",0.760237493549547,0.25844366931247,1.15988135689392,-5.30484384867546,0.828968440144433,"DEPDC4","DEP domain containing 4",TRUE
+"205223_at",0.946277807642742,0.756706362424941,0.313669074534505,-5.89187546325228,0.172562449198058,"DEPDC5","DEP domain containing 5",TRUE
+"228293_at",0.40221114169538,0.014595096572906,2.64936897558749,-2.99986068355289,3.29275095427043,"DEPDC7","DEP domain containing 7",TRUE
+"234071_at",0.42796179417767,0.0185428357515209,-2.54140494241744,-3.20493057268683,-1.86560407612789,"DEPTOR","DEP domain containing MTOR-interacting protein",TRUE
+"218858_at",0.466300647363886,0.0243157717832039,-2.4170967327893,-3.4355776369784,-2.67719692303101,"DEPTOR","DEP domain containing MTOR-interacting protein",TRUE
+"218102_at",0.432151440378733,0.019263843903608,2.52404948753771,-3.23749574350633,1.29921537236069,"DERA","deoxyribose-phosphate aldolase",TRUE
+"222543_at",0.936992192746977,0.718013221674618,-0.365759753141901,-5.87473331056385,-0.160944348019761,"DERL1","derlin 1",TRUE
+"218172_s_at",0.95743098854986,0.807957209020096,-0.245986368396504,-5.91025453368635,-0.114848986323427,"DERL1","derlin 1",TRUE
+"219402_s_at",0.957571530817866,0.809593300004704,-0.243846628914257,-5.91076355989301,-0.134349815535829,"DERL1","derlin 1",TRUE
+"225488_at",0.979347742195592,0.900357164759121,-0.126653286099814,-5.93187349324924,-0.0475128471161606,"DERL1","derlin 1",TRUE
+"218333_at",0.5908222166806,0.0684024623975894,1.91565734513078,-4.29475759108617,0.698904867314479,"DERL2","derlin 2",TRUE
+"226719_at",0.610033432202476,0.0824451645795477,1.81905514349742,-4.44496801554825,1.09377058627622,"DERL2","derlin 2",TRUE
+"229719_s_at",0.663309898243682,0.131251058274381,-1.56715160842009,-4.80942168355912,-1.27116607693446,"DERL3","derlin 3",TRUE
+"228897_at",0.739367922105944,0.22746619882414,1.24132823751776,-5.2158066169941,0.326442175670737,"DERL3","derlin 3",TRUE
+"229721_x_at",0.95970955193902,0.818156410310257,0.23266619341712,-5.91335136212675,0.10294629117407,"DERL3","derlin 3",TRUE
+"216947_at",0.837839105061376,0.422524476164331,-0.81718269599302,-5.61955993585076,-0.60766202961917,"DES","desmin",TRUE
+"202222_s_at",0.881466832418197,0.538196896998972,0.62524557602617,-5.75104788167838,0.319121445197367,"DES","desmin",TRUE
+"212527_at",0.865854896594418,0.496154255332476,0.69195380289218,-5.70913024127468,0.224884947681886,"DESI1","desumoylating isopeptidase 1",TRUE
+"212528_at",0.99739241902969,0.986866668215239,0.0166477057787646,-5.93954849399985,0.00592461558367674,"DESI1","desumoylating isopeptidase 1",TRUE
+"222936_s_at",0.801587742916188,0.338895080786636,0.977457608441406,-5.48474715287704,1.09588363811869,"DESI2","desumoylating isopeptidase 2",TRUE
+"1558914_at",0.933859583363678,0.707038269682854,-0.3807180164616,-5.86933106058398,-0.102637657353315,"DESI2","desumoylating isopeptidase 2",TRUE
+"219875_s_at",0.937757781799543,0.724581897574824,-0.356847725416318,-5.87785032502676,-0.134633988612894,"DESI2","desumoylating isopeptidase 2",TRUE
+"212371_at",0.957505144213208,0.808279696863583,-0.245564514452852,-5.91035523914707,-0.081471653480941,"DESI2","desumoylating isopeptidase 2",TRUE
+"222158_s_at",0.979588787486838,0.902889720935914,0.123416868235436,-5.93226739191145,0.0507912765275282,"DESI2","desumoylating isopeptidase 2",TRUE
+"1558348_at",0.936318756756998,0.715598401489457,0.369043614778109,-5.87356563098746,0.245929354270798,"DET1","de-etiolated homolog 1 (Arabidopsis)",TRUE
+"219641_at",0.937236261824892,0.721562509548623,-0.360940568263435,-5.87642826565776,-0.173437718532028,"DET1","de-etiolated homolog 1 (Arabidopsis)",TRUE
+"1558894_a_at",0.55937703282623,0.0537188210845338,2.03748074823717,-4.09773990073483,0.721467893035355,"DEUP1","deuterosome assembly protein 1",TRUE
+"1554072_s_at",0.792436690618566,0.323930442863335,1.00886545653344,-5.45574426005715,0.996784987729353,"DEUP1","deuterosome assembly protein 1",TRUE
+"1558893_a_at",0.81031378318664,0.35401207070889,0.946681586696043,-5.51235454530481,0.849613993030233,"DEUP1","deuterosome assembly protein 1",TRUE
+"1554071_at",0.990810941805126,0.955828382706496,-0.0560194899665674,-5.93815510297524,-0.0490657377146282,"DEUP1","deuterosome assembly protein 1",TRUE
+"203733_at",0.778481681746654,0.298495089101862,-1.06466050677688,-5.40218023079579,-0.313971486159817,"DEXI","Dexi homolog",TRUE
+"203277_at",0.79814964343286,0.332401194568764,0.990966862213615,-5.47237449878856,0.399303465995207,"DFFA","DNA fragmentation factor subunit alpha",TRUE
+"226116_at",0.835952408568777,0.416506601854541,0.82798876035087,-5.61117501778777,0.322110084442137,"DFFA","DNA fragmentation factor subunit alpha",TRUE
+"223518_at",0.896159990898752,0.579315941988858,0.562659526811722,-5.78665156202522,0.256301800496173,"DFFA","DNA fragmentation factor subunit alpha",TRUE
+"206752_s_at",0.909304648717545,0.62344372362569,0.497924040453986,-5.81964287922849,0.206086070355551,"DFFB","DNA fragmentation factor subunit beta",TRUE
+"203695_s_at",0.322131160460075,0.0071947721337784,2.9602297318847,-2.38817656401001,3.36217529782292,"DFNA5","DFNA5, deafness associated tumor suppressor",TRUE
+"235365_at",0.863468033337798,0.488124541816433,0.705051277495098,-5.70042339117675,0.246051956682269,"DFNB59","deafness, autosomal recessive 59",TRUE
+"203669_s_at",0.778006206647445,0.297192892991201,1.06760624482864,-5.39928032902984,0.69218497971756,"DGAT1","diacylglycerol O-acyltransferase 1",TRUE
+"226064_s_at",0.771159692311272,0.280269877860458,1.10675906845475,-5.36005814750124,0.738638197015555,"DGAT2","diacylglycerol O-acyltransferase 2",TRUE
+"224327_s_at",0.928576500287959,0.685950174487452,0.409713658726386,-5.85825158503348,0.288037488140279,"DGAT2","diacylglycerol O-acyltransferase 2",TRUE
+"1557451_at",0.83030603167465,0.402497928719572,0.853532038849074,-5.59094568317023,0.299972708649654,"DGCR10","DiGeorge syndrome critical region gene 10 (non-protein coding)",TRUE
+"215725_at",0.836924520231997,0.419005667897768,0.823489446836798,-5.61467877434632,0.611131066942954,"DGCR11","DiGeorge syndrome critical region gene 11 (non-protein coding)",TRUE
+"1566235_at",0.753606468220283,0.246852789485131,1.18945162311142,-5.27312553984626,0.722678177527691,"DGCR12","DiGeorge syndrome critical region gene 12 (non-protein coding)",TRUE
+"1566236_at",0.922486281852799,0.668821768224734,-0.433529520701531,-5.8485533128393,-0.269439310815535,"DGCR12","DiGeorge syndrome critical region gene 12 (non-protein coding)",TRUE
+"241748_x_at",0.982909728377256,0.917104723964428,0.105275164760145,-5.93428686940268,0.032317808832965,"DGCR14","DiGeorge syndrome critical region gene 14",TRUE
+"214198_s_at",0.822452640841017,0.387324211069784,-0.881851210034545,-5.56784931367471,-0.385209249698111,"DGCR2","DiGeorge syndrome critical region gene 2",TRUE
+"202099_s_at",0.896159990898752,0.579262648085167,-0.562739140182574,-5.78660857930566,-0.230442008343383,"DGCR2","DiGeorge syndrome critical region gene 2",TRUE
+"227028_s_at",0.971216837324271,0.862658561338105,0.175013407751829,-5.92477588880113,0.110389526015883,"DGCR2","DiGeorge syndrome critical region gene 2",TRUE
+"215244_at",0.654623800601032,0.123593908582601,-1.60075582096129,-4.76320146053492,-1.15906708141353,"DGCR5","DiGeorge syndrome critical region gene 5 (non-protein coding)",TRUE
+"228804_at",0.995810723090838,0.979889677333454,-0.0254933384611305,-5.93936693835876,-0.0199185453661626,"DGCR5","DiGeorge syndrome critical region gene 5 (non-protein coding)",TRUE
+"214024_s_at",0.772700799794446,0.283177781448048,1.09991222557091,-5.36700784954934,0.546231399324216,"DGCR6L","DiGeorge syndrome critical region gene 6-like",TRUE
+"208024_s_at",0.599747222491044,0.0762211669845788,-1.85994562737006,-4.38205726569379,-0.838465403713718,"DGCR6L///DGCR6","DiGeorge syndrome critical region gene 6-like///DiGeorge syndrome critical region gene 6",TRUE
+"1566037_at",0.753862100951903,0.247254238267137,-1.18841032692248,-5.2742543183613,-0.833312584360685,"DGCR7","DiGeorge syndrome critical region gene 7",TRUE
+"1566038_at",0.976392182310915,0.887532528442684,-0.143064259157221,-5.92971948765074,-0.0534424236764388,"DGCR7","DiGeorge syndrome critical region gene 7",TRUE
+"215003_at",0.782206338814045,0.304169708971519,-1.0519296411033,-5.41463037241324,-0.6044027612757,"DGCR9","DiGeorge syndrome critical region gene 9 (non-protein coding)",TRUE
+"203385_at",0.567651250567208,0.0576861825390349,2.00190617593469,-4.15611768251067,0.864648344299258,"DGKA","diacylglycerol kinase alpha",TRUE
+"211272_s_at",0.716472449896956,0.192394191807316,1.34448924608363,-5.09562358455411,0.708784702373967,"DGKA","diacylglycerol kinase alpha",TRUE
+"1553524_at",0.699418568645285,0.170988231122063,1.41493706938851,-5.00894204913063,0.741105191032052,"DGKB","diacylglycerol kinase beta",TRUE
+"216307_at",0.827313679098971,0.39609675679513,-0.865393151943695,-5.58135737898314,-0.708918683740312,"DGKB","diacylglycerol kinase beta",TRUE
+"208072_s_at",0.784925710185113,0.309975383225478,-1.03907804157934,-5.42706207098731,-0.416478717902301,"DGKD","diacylglycerol kinase delta",TRUE
+"207518_at",0.870980161749509,0.511218769660593,0.667702914818877,-5.72483960172595,0.447941653355885,"DGKE","diacylglycerol kinase epsilon",TRUE
+"238457_at",0.872495559811184,0.515646072687312,0.660652275168799,-5.72930622211783,0.335073506975266,"DGKE","diacylglycerol kinase epsilon",TRUE
+"1554623_x_at",0.942373096422033,0.741177166450171,0.334460868632455,-5.88534500509438,0.266880657266942,"DGKE","diacylglycerol kinase epsilon",TRUE
+"1554621_at",0.957283234301336,0.806604139387805,0.247756849054905,-5.9098300084956,0.182470316423537,"DGKE","diacylglycerol kinase epsilon",TRUE
+"238694_at",0.971242929121865,0.863344784005111,-0.174129646181226,-5.92492595616622,-0.154777268194252,"DGKE","diacylglycerol kinase epsilon",TRUE
+"206395_at",0.100739703627073,0.000457262895915294,4.10857745425461,0.0336717702163449,2.91734866974211,"DGKG","diacylglycerol kinase gamma",TRUE
+"242319_at",0.789378278298554,0.315662493667707,1.02665259528959,-5.43895062946697,0.607670127421367,"DGKG","diacylglycerol kinase gamma",TRUE
+"216349_at",0.804779510162821,0.343897144988226,0.967172423984424,-5.49406317397721,0.323988155061633,"DGKH","diacylglycerol kinase eta",TRUE
+"240145_at",0.821962235882611,0.385136562452162,0.885993111332995,-5.56441263461459,0.343670861127217,"DGKH","diacylglycerol kinase eta",TRUE
+"227415_at",0.823074246722209,0.389781761308603,0.877216443433466,-5.57167722992348,0.412853203598358,"DGKH","diacylglycerol kinase eta",TRUE
+"235952_at",0.843095426822889,0.437358715742635,0.790949319100568,-5.63948531523437,0.402552748826317,"DGKH","diacylglycerol kinase eta",TRUE
+"1553300_a_at",0.919931255639931,0.65905271666056,0.447226815302735,-5.8427318522943,0.26762606257579,"DGKH","diacylglycerol kinase eta",TRUE
+"206806_at",0.992451894371035,0.964829677093701,0.044594909343549,-5.93871490182892,0.0330196180937561,"DGKI","diacylglycerol kinase iota",TRUE
+"238194_at",0.892895911526563,0.566538638432197,0.581854103913096,-5.7761180030303,0.17440003526214,"DGKK","diacylglycerol kinase kappa",TRUE
+"226605_at",0.431599123815241,0.0191585015729235,-2.52654696352965,-3.23281662110065,-0.989523112680759,"DGKQ","diacylglycerol kinase theta",TRUE
+"207562_at",0.98529096111871,0.926980335919816,0.0926931961098987,-5.93549948670824,0.064919545525262,"DGKQ","diacylglycerol kinase theta",TRUE
+"207556_s_at",0.631316839203356,0.102627368442694,-1.70262939052234,-4.61848497567483,-0.958450955312262,"DGKZ","diacylglycerol kinase zeta",TRUE
+"239342_at",0.974982245454858,0.878382285874177,0.15479768773794,-5.92801905114906,0.0647827616651648,"DGKZ","diacylglycerol kinase zeta",TRUE
+"203816_at",0.843095426822889,0.437192983537227,0.79123933865571,-5.63926837436057,0.260953456747457,"DGUOK","deoxyguanosine kinase",TRUE
+"241995_at",0.918482003504129,0.653873015044059,0.454524575817012,-5.83955772532242,0.128207646987263,"DGUOK","deoxyguanosine kinase",TRUE
+"209549_s_at",0.933809945444433,0.706638366398134,0.381264715753499,-5.86912957231976,0.108975257259804,"DGUOK","deoxyguanosine kinase",TRUE
+"200862_at",0.683254141963065,0.152332931094297,-1.48234446027986,-4.92260884655261,-0.77115062032137,"DHCR24","24-dehydrocholesterol reductase",TRUE
+"201791_s_at",0.738061563377262,0.224910505438718,-1.24841444974019,-5.2078131650631,-0.676283995435881,"DHCR7","7-dehydrocholesterol reductase",TRUE
+"201790_s_at",0.916443520723728,0.647009323327007,-0.464233779018803,-5.83525670063204,-0.214412670632091,"DHCR7","7-dehydrocholesterol reductase",TRUE
+"224064_s_at",0.893462835798285,0.568314989454907,0.579172516244657,-5.77761016221191,0.180556201990084,"DHDDS","dehydrodolichyl diphosphate synthase subunit",TRUE
+"218547_at",0.980599519736839,0.909343518055733,0.115175413692625,-5.9332244699377,0.0342655438153354,"DHDDS","dehydrodolichyl diphosphate synthase subunit",TRUE
+"231416_at",0.67622507827427,0.142775674379644,1.51951264396748,-4.8736199338301,0.627579015196766,"DHDH","dihydrodiol dehydrogenase",TRUE
+"202534_x_at",0.41501369736632,0.0167979023735101,-2.58617000003526,-3.12041455089742,-0.951097957046867,"DHFR","dihydrofolate reductase",TRUE
+"48808_at",0.559167054471987,0.0528505770215168,-2.04557735859946,-4.08435844360727,-0.7929389780838,"DHFR","dihydrofolate reductase",TRUE
+"202532_s_at",0.605167906652425,0.0790066487002287,-1.84129996816998,-4.41086784166555,-0.671072688299859,"DHFR","dihydrofolate reductase",TRUE
+"202533_s_at",0.69450946988669,0.163915154022886,-1.43976174010408,-4.97752836206751,-0.502923103693943,"DHFR","dihydrofolate reductase",TRUE
+"235675_at",0.912722788750542,0.633831298285808,-0.483003833249502,-5.82668958496413,-0.291477747076888,"DHFR2","dihydrofolate reductase 2",TRUE
+"241727_x_at",0.917113901833643,0.649737667810264,-0.460368958482399,-5.83697942613259,-0.13288066348963,"DHFR2","dihydrofolate reductase 2",TRUE
+"1552730_at",0.856257656023992,0.470087001870553,0.734935028826344,-5.67997587185598,0.537678583037954,"DHH","desert hedgehog",TRUE
+"213631_x_at",0.575986890549489,0.0611120247293568,-1.97289510802307,-4.20321439429309,-0.583518131378709,"DHODH","dihydroorotate dehydrogenase (quinone)",TRUE
+"217647_at",0.774230543658252,0.288617617448853,-1.08723918684122,-5.37977001240138,-0.861312412804059,"DHODH","dihydroorotate dehydrogenase (quinone)",TRUE
+"213632_at",0.919378883093968,0.657382553708056,0.449577220483913,-5.84171505455815,0.116663592262942,"DHODH","dihydroorotate dehydrogenase (quinone)",TRUE
+"202802_at",0.822010986888098,0.385757844540142,0.884815272770832,-5.56539144710035,0.392593020129677,"DHPS","deoxyhypusine synthase",TRUE
+"207831_x_at",0.872668627020452,0.516080783030333,0.659961800237273,-5.72974119856689,0.289738924361092,"DHPS","deoxyhypusine synthase",TRUE
+"211558_s_at",0.878260796317638,0.530691905954337,0.636937751072889,-5.74399551312452,0.280530449406816,"DHPS","deoxyhypusine synthase",TRUE
+"213279_at",0.724970327905974,0.202526386971942,1.31328220891378,-5.13283721425106,0.529543084861045,"DHRS1","dehydrogenase/reductase 1",TRUE
+"218756_s_at",0.88113080359582,0.537291166526017,0.626651951360199,-5.75020625198807,0.320886955427982,"DHRS11","dehydrogenase/reductase 11",TRUE
+"231345_s_at",0.837067957688307,0.419500029500913,0.8226014013317,-5.61536821089267,0.520952966318222,"DHRS12","dehydrogenase/reductase 12",TRUE
+"204801_s_at",0.879447209955825,0.533921656906981,-0.631895192357663,-5.74705245102713,-0.429857771894585,"DHRS12","dehydrogenase/reductase 12",TRUE
+"204800_s_at",0.89961817630669,0.590700560261794,-0.5457354360388,-5.79565474533038,-0.233526040836114,"DHRS12","dehydrogenase/reductase 12",TRUE
+"226121_at",0.669104388501409,0.135228230323559,-1.55033471437446,-4.83226302418585,-0.625867701971599,"DHRS13","dehydrogenase/reductase 13",TRUE
+"206463_s_at",0.828607509614823,0.399021850224736,-0.859957891291425,-5.58576643354109,-1.41340894674309,"DHRS2","dehydrogenase/reductase 2",TRUE
+"214079_at",0.868313590269077,0.502518127540816,-0.681659208588753,-5.71586437715039,-0.97782020052813,"DHRS2","dehydrogenase/reductase 2",TRUE
+"202481_at",0.517859245504688,0.0369947262162375,2.21949383854757,-3.78879004360455,2.41377164332395,"DHRS3","dehydrogenase/reductase 3",TRUE
+"227446_s_at",0.62986301194198,0.101140873939202,-1.71050170455147,-4.60702070409201,-0.895765024654093,"DHRS4-AS1","DHRS4 antisense RNA 1",TRUE
+"224153_s_at",0.966064677476069,0.841693192214809,0.202086388329382,-5.919811906919,0.0994797190531544,"DHRS4-AS1","DHRS4 antisense RNA 1",TRUE
+"218021_at",0.548924465506383,0.0485436425143576,-2.08758894196309,-4.01436931098509,-0.756614661175725,"DHRS4L2///DHRS4","dehydrogenase/reductase 4 like 2///dehydrogenase/reductase 4",TRUE
+"213868_s_at",0.854184492233394,0.464250602423686,-0.744748395238762,-5.67308546610214,-0.475688614420637,"DHRS7","dehydrogenase/reductase 7",TRUE
+"236332_at",0.899798994481376,0.591633187651541,-0.544356198099012,-5.79637669639816,-0.146867659140363,"DHRS7","dehydrogenase/reductase 7",TRUE
+"210788_s_at",0.922045206810628,0.667245370876439,-0.43573404078829,-5.84762837560552,-0.187024837280415,"DHRS7","dehydrogenase/reductase 7",TRUE
+"220690_s_at",0.933298127911264,0.704821170631163,0.383750459493065,-5.86820984644374,0.328694965475078,"DHRS7B","dehydrogenase/reductase 7B",TRUE
+"230915_at",0.915569510513076,0.64386188562856,0.468701201433307,-5.83324779431541,0.20028756378418,"DHRS7C","dehydrogenase/reductase 7C",TRUE
+"224009_x_at",0.547343369043481,0.047820592026371,2.09496715862423,-4.00198252070264,1.78458115042306,"DHRS9","dehydrogenase/reductase 9",TRUE
+"219799_s_at",0.657015752622694,0.1252540516545,1.59332596761801,-4.77348657454354,1.47864408140404,"DHRS9","dehydrogenase/reductase 9",TRUE
+"223952_x_at",0.676475496596199,0.143424100608412,1.51692757054756,-4.87705854390502,1.35561580678855,"DHRS9","dehydrogenase/reductase 9",TRUE
+"225503_at",0.686108994812404,0.154656340623588,-1.47359693043176,-4.93399644389138,-1.35394086239956,"DHRSX","dehydrogenase/reductase X-linked",TRUE
+"238053_at",0.998507818207624,0.993733541720536,-0.0079430159731571,-5.93965275125099,-0.00423113457366853,"DHRSX","dehydrogenase/reductase X-linked",TRUE
+"209916_at",0.929126743655924,0.688366708182573,0.406373270535472,-5.85956876630846,0.233586216741186,"DHTKD1","dehydrogenase E1 and transketolase domain containing 1",TRUE
+"227094_at",0.971216837324271,0.862075115848356,-0.175764918481758,-5.92464768240438,-0.09402661378323,"DHTKD1","dehydrogenase E1 and transketolase domain containing 1",TRUE
+"201386_s_at",0.965620759643697,0.839312295614075,0.205170291230738,-5.9192014051588,0.0618325997134832,"DHX15","DEAH-box helicase 15",TRUE
+"201385_at",0.979347742195592,0.900237741109066,0.12680593455057,-5.93185466327698,0.033691019046513,"DHX15","DEAH-box helicase 15",TRUE
+"203694_s_at",0.873628468770492,0.519060091490271,0.655238239258462,-5.73270518673095,0.174654644466367,"DHX16","DEAH-box helicase 16",TRUE
+"212648_at",0.348854934125219,0.00919093610713453,-2.85382906280249,-2.60076938051549,-0.791942411289021,"DHX29","DEAH-box helicase 29",TRUE
+"212649_at",0.962555471240652,0.8297408080179,-0.217588839428735,-5.91664979768918,-0.0766080460913985,"DHX29","DEAH-box helicase 29",TRUE
+"230871_at",0.514104154598251,0.0345798098686745,-2.25175165478685,-3.73233530031542,-1.00217021062651,"DHX30","DEAH-box helicase 30",TRUE
+"204355_at",0.598790786356002,0.0756661922128698,-1.86373128586449,-4.3761826453822,-0.705761814186546,"DHX30","DEAH-box helicase 30",TRUE
+"212674_s_at",0.645740804644555,0.116900836218804,-1.63158263563237,-4.7201324934982,-0.629107667759442,"DHX30","DEAH-box helicase 30",TRUE
+"236844_at",0.956960361976289,0.805079075201054,-0.249753354271803,-5.90934765649592,-0.101548053061341,"DHX30","DEAH-box helicase 30",TRUE
+"1556144_at",0.998259373165125,0.991741246119493,-0.0104684244847624,-5.93963010465897,-0.00382283419276153,"DHX30","DEAH-box helicase 30",TRUE
+"239772_x_at",0.998870448604467,0.996205965016106,0.00480907545391242,-5.93967221634568,0.00261654429133529,"DHX30","DEAH-box helicase 30",TRUE
+"218198_at",0.98529096111871,0.926800342887315,-0.0929223718227065,-5.93547877633245,-0.0340257840561975,"DHX32","DEAH-box helicase 32 (putative)",TRUE
+"222875_at",0.455383508065457,0.0221799045629321,2.45952812570149,-3.35753934332649,0.966929133782108,"DHX33","DEAH-box helicase 33",TRUE
+"226262_at",0.640067422642767,0.110590099762402,1.66203624305747,-4.67696571427348,0.598491947108188,"DHX33","DEAH-box helicase 33",TRUE
+"214017_s_at",0.854184492233394,0.464815999647692,-0.74379454142985,-5.67375901193431,-0.250213461892544,"DHX34","DEAH-box helicase 34",TRUE
+"204815_s_at",0.873709858086966,0.519406002968754,0.65469078389614,-5.73304738895445,0.390145417027951,"DHX34","DEAH-box helicase 34",TRUE
+"204816_s_at",0.985425981490741,0.928945625834521,0.0901912234550032,-5.93572226326618,0.0667215720767205,"DHX34","DEAH-box helicase 34",TRUE
+"1561132_at",0.784552021081681,0.308153444523646,1.04309266106645,-5.42319338425165,0.667035566569094,"DHX35","DEAH-box helicase 35",TRUE
+"234728_s_at",0.94943075115007,0.771464400173421,-0.294039828827906,-5.89765980028204,-0.134021733396198,"DHX35","DEAH-box helicase 35",TRUE
+"218579_s_at",0.955489732080505,0.7959006651695,0.261791328913594,-5.90635777483933,0.180650449815748,"DHX35","DEAH-box helicase 35",TRUE
+"223138_s_at",0.585036027492332,0.0654063361885526,1.93849664729586,-4.25845134517926,0.632773940487459,"DHX36","DEAH-box helicase 36",TRUE
+"1559039_at",0.660446284140125,0.128373170433037,1.57958553949953,-4.7924090421581,0.639787610920929,"DHX36","DEAH-box helicase 36",TRUE
+"223140_s_at",0.760439386481756,0.259237461319028,1.15789260811532,-5.30695196217094,0.321205340760759,"DHX36","DEAH-box helicase 36",TRUE
+"223139_s_at",0.918775990454959,0.655135881295762,0.452743007455399,-5.84033725784242,0.123467941925766,"DHX36","DEAH-box helicase 36",TRUE
+"223364_s_at",0.883154480220886,0.540935862904554,0.621000339700714,-5.75357735000894,0.234451932854061,"DHX37","DEAH-box helicase 37",TRUE
+"223365_at",0.900867933475689,0.59689476656114,0.536594858206436,-5.80040619088576,0.176499310173764,"DHX37","DEAH-box helicase 37",TRUE
+"209178_at",0.952670965982815,0.783295279621628,0.278389022971595,-5.90200620742755,0.0786284708775415,"DHX38","DEAH-box helicase 38",TRUE
+"218277_s_at",0.789795896476304,0.318494798922719,-1.02052305279584,-5.44476776899702,-0.445625984020113,"DHX40","DEAH-box helicase 40",TRUE
+"222574_s_at",0.794141158642576,0.325892001398509,-1.00469207380268,-5.45964604373965,-0.498934948465919,"DHX40","DEAH-box helicase 40",TRUE
+"213420_at",0.677163945383887,0.144649471805447,1.51206843922976,-4.88350940904412,0.524829405529886,"DHX57","DEAH-box helicase 57",TRUE
+"244784_at",0.913782990161554,0.638504505025285,0.476327763871625,-5.82977477428113,0.270635152269662,"DHX57","DEAH-box helicase 57",TRUE
+"219364_at",0.620223198657182,0.090189820522492,1.77175295111079,-4.51648173372855,1.15220600405768,"DHX58","DEXH-box helicase 58",TRUE
+"227079_at",0.914966942918905,0.641883994340771,0.4715135439372,-5.83197348189382,0.146733370924702,"DHX8","DEAH-box helicase 8",TRUE
+"203334_at",0.976994788692278,0.890305742135697,-0.139512279621584,-5.93020788585493,-0.042679264518755,"DHX8","DEAH-box helicase 8",TRUE
+"231184_at",0.988802593747325,0.946198191178943,-0.068250782951966,-5.93741491285304,-0.0357321990598884,"DHX8","DEAH-box helicase 8",TRUE
+"202420_s_at",0.851733415458562,0.455986753672714,-0.758769797308754,-5.66309020635274,-0.211831895080357,"DHX9","DEAH-box helicase 9",TRUE
+"212107_s_at",0.936456142259101,0.716392714883532,0.367962990671962,-5.87395101784859,0.162694151914504,"DHX9","DEAH-box helicase 9",TRUE
+"212105_s_at",0.979316963724958,0.900022291600397,0.127081331979635,-5.93182063430339,0.0555600847956068,"DHX9","DEAH-box helicase 9",TRUE
+"219350_s_at",0.7768734672127,0.294895412389413,-1.07282602294561,-5.39412416283949,-0.358482066767204,"DIABLO","diablo IAP-binding mitochondrial protein",TRUE
+"213514_s_at",0.522403182336918,0.0382342586235547,2.20367408102724,-3.81629596227349,0.667435867099773,"DIAPH1","diaphanous related formin 1",TRUE
+"209190_s_at",0.631360647647282,0.102726736560955,1.70210661268807,-4.61924487976976,0.440524057016956,"DIAPH1","diaphanous related formin 1",TRUE
+"215541_s_at",0.803566977998733,0.341782351593243,0.971508266500351,-5.4901468568775,0.255814325943264,"DIAPH1","diaphanous related formin 1",TRUE
+"1560080_at",0.980001024522674,0.904943466158081,-0.120793327701369,-5.9325792268632,-0.112032570629397,"DIAPH1","diaphanous related formin 1",TRUE
+"205726_at",0.806341956816164,0.347281059622219,0.960272250360016,-5.50026270076719,0.550985826388313,"DIAPH2","diaphanous related formin 2",TRUE
+"205603_s_at",0.910165867297668,0.626610428518439,0.493363543444406,-5.82181899125227,0.318402567550772,"DIAPH2","diaphanous related formin 2",TRUE
+"217246_s_at",0.91339551560427,0.636911780389512,0.478600623745101,-5.82872914055969,0.459095059957207,"DIAPH2","diaphanous related formin 2",TRUE
+"217050_at",0.497725944448536,0.0307853296684391,2.30685196436113,-3.63478798495203,1.60662380210436,"DIAPH2-AS1","DIAPH2 antisense RNA 1",TRUE
+"217245_at",0.833141091249911,0.410433893741182,0.83899356956182,-5.60252999326157,0.443600686395973,"DIAPH2-AS1","DIAPH2 antisense RNA 1",TRUE
+"229097_at",0.606192735863141,0.0798701198466933,1.83563606508867,-4.41957848783092,0.771308206767545,"DIAPH3","diaphanous related formin 3",TRUE
+"232596_at",0.689848451630875,0.158705213198986,1.45860469630373,-4.95338656789293,1.14312579493446,"DIAPH3","diaphanous related formin 3",TRUE
+"220997_s_at",0.913300726876965,0.636578938278623,0.479075921030626,-5.82850986355834,0.330047400094439,"DIAPH3","diaphanous related formin 3",TRUE
+"242102_at",0.695744345349551,0.16538605988685,1.43452935003714,-4.98418673249368,1.30304730959718,"DIAPH3-AS1","DIAPH3 antisense RNA 1",TRUE
+"1555994_at",0.748259306393984,0.24082522203228,1.20524104261711,-5.25590423064064,0.64400853701347,"DIAPH3-AS1","DIAPH3 antisense RNA 1",TRUE
+"1555995_a_at",0.961212424803935,0.824317807462402,-0.224640358306813,-5.91513451831032,-0.0724266413856478,"DIAPH3-AS1","DIAPH3 antisense RNA 1",TRUE
+"216260_at",0.632024529529662,0.102915681037427,-1.70111375607254,-4.62068760258771,-0.672931276480994,"DICER1","dicer 1, ribonuclease III",TRUE
+"212888_at",0.896118635245982,0.578274539107607,0.56421589853614,-5.7858102181558,0.16193314124785,"DICER1","dicer 1, ribonuclease III",TRUE
+"206061_s_at",0.943512938262733,0.747519085867927,0.325952128089202,-5.88806763508195,0.122586902346201,"DICER1","dicer 1, ribonuclease III",TRUE
+"213229_at",0.953622331321215,0.786461912597243,0.274212139056595,-5.90312629998184,0.105971845631629,"DICER1","dicer 1, ribonuclease III",TRUE
+"216281_at",0.977858230085336,0.892573792281254,-0.13660868996469,-5.93059802633435,-0.058438702514366,"DICER1","dicer 1, ribonuclease III",TRUE
+"216280_s_at",0.994050962712312,0.972091113613973,-0.0353830868463601,-5.939073714209,-0.0256959344882439,"DICER1","dicer 1, ribonuclease III",TRUE
+"1557063_at",0.863993702749895,0.49055891829671,-0.701067528573199,-5.70308815856202,-0.547495782880395,"DICER1-AS1","DICER1 antisense RNA 1",TRUE
+"229227_at",0.937623890519979,0.724014340337129,-0.357616584924227,-5.87758440644945,-0.16245268803867,"DICER1-AS1","DICER1 antisense RNA 1",TRUE
+"227335_at",0.232037111848437,0.00298348586427894,-3.33470234581322,-1.6187013945583,-1.23602530752144,"DIDO1","death inducer-obliterator 1",TRUE
+"218325_s_at",0.840983766802785,0.430695327722164,0.80266365788183,-5.63066323758124,0.419378036514765,"DIDO1","death inducer-obliterator 1",TRUE
+"222595_s_at",0.84909821650357,0.449839578221169,0.769299112817347,-5.65546841199662,0.389003091823323,"DIDO1","death inducer-obliterator 1",TRUE
+"213213_at",0.937842878751575,0.724835798974817,-0.35650384077229,-5.8779690783643,-0.144303289969585,"DIDO1","death inducer-obliterator 1",TRUE
+"204699_s_at",0.848364007856994,0.448377949244805,0.771815479420227,-5.65363221582431,0.333682276835212,"DIEXF","digestive organ expansion factor homolog (zebrafish)",TRUE
+"214193_s_at",0.896115372949367,0.577655555866782,-0.565141633506029,-5.78530871518715,-0.251717148017649,"DIEXF","digestive organ expansion factor homolog (zebrafish)",TRUE
+"220251_at",0.912421110187259,0.633247942124775,-0.483838765749725,-5.82630078642564,-0.191034097387764,"DIEXF","digestive organ expansion factor homolog (zebrafish)",TRUE
+"204700_x_at",0.963379172403332,0.833007717934885,-0.213346344745652,-5.91753827748361,-0.081699482592489,"DIEXF","digestive organ expansion factor homolog (zebrafish)",TRUE
+"210801_at",0.698306882959363,0.169202918801018,1.42112416166683,-5.00115467381098,0.920956846968042,"DIMT1","DIM1 dimethyladenosine transferase 1 homolog",TRUE
+"210802_s_at",0.933938389322633,0.707367583726375,-0.380267906922394,-5.86949673629814,-0.166873330254484,"DIMT1","DIM1 dimethyladenosine transferase 1 homolog",TRUE
+"204405_x_at",0.973684290975695,0.873296925858463,0.161328208894826,-5.92701473546029,0.062812174869272,"DIMT1","DIM1 dimethyladenosine transferase 1 homolog",TRUE
+"217106_x_at",0.992093589969215,0.963302191596337,-0.0465331460615386,-5.93862888157904,-0.0168045476857319,"DIMT1","DIM1 dimethyladenosine transferase 1 homolog",TRUE
+"206457_s_at",0.966488115172937,0.843580170686473,0.199643667470267,-5.92028894115639,0.207858020926912,"DIO1","deiodinase, iodothyronine type I",TRUE
+"203699_s_at",0.327864702134751,0.00763635246812536,2.93445188972826,-2.43996296449675,3.32953039498541,"DIO2","deiodinase, iodothyronine, type II",TRUE
+"231240_at",0.497885178357455,0.0309595855064296,2.3041886953626,-3.63953467783588,2.20861687125827,"DIO2","deiodinase, iodothyronine, type II",TRUE
+"203700_s_at",0.562894650172193,0.05547710735186,2.02143549413232,-4.12415466250015,1.71461841286297,"DIO2","deiodinase, iodothyronine, type II",TRUE
+"210819_x_at",0.640987277293074,0.111470886376519,1.65769934307623,-4.68315034345506,0.922657004709397,"DIO2","deiodinase, iodothyronine, type II",TRUE
+"211215_x_at",0.814950844716166,0.365792568453213,0.923308833091866,-5.53277960051393,0.73502861366886,"DIO2","deiodinase, iodothyronine, type II",TRUE
+"1562827_at",0.763391321581193,0.263111005678322,1.14825201659735,-5.31712613564355,0.487889781442677,"DIO2-AS1","DIO2 antisense RNA 1",TRUE
+"207154_at",0.944793138991092,0.751660862415755,-0.320408505419736,-5.88980412461989,-0.234299927219281,"DIO3","deiodinase, iodothyronine, type III",TRUE
+"1559326_at",0.697172073261335,0.167243817631168,-1.42797404072636,-4.99250057545872,-0.719898624197604,"DIO3OS","DIO3 opposite strand/antisense RNA (head to head)",TRUE
+"223757_at",0.992719003179959,0.965699620846244,0.0434911105425587,-5.93876225418049,0.036096409554955,"DIO3OS","DIO3 opposite strand/antisense RNA (head to head)",TRUE
+"1554969_x_at",0.667209925683767,0.133748829022731,1.55654177323633,-4.82385496704204,1.16448872894567,"DIP2A","disco interacting protein 2 homolog A",TRUE
+"1561286_a_at",0.697713925841949,0.168701100040715,1.42287265514522,-4.99894888048572,0.531988637585674,"DIP2A","disco interacting protein 2 homolog A",TRUE
+"1555301_a_at",0.705559553212919,0.177259316481631,1.39360557794868,-5.03557621814398,0.698417742706546,"DIP2A","disco interacting protein 2 homolog A",TRUE
+"1552677_a_at",0.900692252557887,0.596030968791996,0.537866745468556,-5.79974971321823,0.177005859476055,"DIP2A","disco interacting protein 2 homolog A",TRUE
+"1556127_at",0.908801761853008,0.621308057717751,-0.501005746116901,-5.81816132750807,-0.343171076586634,"DIP2A","disco interacting protein 2 homolog A",TRUE
+"1554967_at",0.943988850936011,0.749616192789177,-0.323143932849568,-5.88895096215163,-0.225790789814493,"DIP2A","disco interacting protein 2 homolog A",TRUE
+"215529_x_at",0.953902670233338,0.787182664791169,0.273262143752306,-5.90337870872785,0.130517024342178,"DIP2A","disco interacting protein 2 homolog A",TRUE
+"227199_at",0.977143718344719,0.890951476928589,0.138685476911514,-5.93031981312689,0.0480467285837758,"DIP2A","disco interacting protein 2 homolog A",TRUE
+"1553271_at",0.851733415458562,0.456056921738065,0.758650103919717,-5.66317627724032,0.462396192542288,"DIP2B","disco interacting protein 2 homolog B",TRUE
+"242970_at",0.888232641270866,0.553811881871576,0.601194672949136,-5.76515865395886,0.326796137815793,"DIP2B","disco interacting protein 2 homolog B",TRUE
+"224872_at",0.949217179291784,0.770734439109158,-0.295007897591768,-5.89738321472891,-0.0792141459001936,"DIP2B","disco interacting protein 2 homolog B",TRUE
+"212504_at",0.380731642340006,0.0118844909323262,-2.74081693114019,-2.82299904406582,-1.19093740723135,"DIP2C","disco interacting protein 2 homolog C",TRUE
+"212503_s_at",0.39149295959037,0.0132342828798991,-2.69306478819333,-2.91569896957586,-1.69192480052219,"DIP2C","disco interacting protein 2 homolog C",TRUE
+"1565681_s_at",0.514490373584066,0.0347604470053871,-2.249268806953,-3.73669791640004,-1.01130629431658,"DIP2C","disco interacting protein 2 homolog C",TRUE
+"1565680_at",0.890737010433392,0.559482220618263,0.592549438497088,-5.77010029646526,0.359135077083819,"DIP2C","disco interacting protein 2 homolog C",TRUE
+"226573_at",0.710871194592606,0.18459897980477,-1.36938894019536,-5.06540651680752,-1.34787524872231,"DIRAS1","DIRAS family GTPase 1",TRUE
+"232854_at",0.967701855457407,0.847994268449042,-0.193934377074984,-5.92138135731079,-0.0744692372313338,"DIRAS1","DIRAS family GTPase 1",TRUE
+"219619_at",0.44258805251056,0.0205853025612136,-2.49375769572651,-3.2940574515764,-2.72275096990474,"DIRAS2","DIRAS family GTPase 2",TRUE
+"240122_at",0.990810941805126,0.953919842569321,0.058442767795738,-5.93802002573339,0.0589129104300348,"DIRAS2","DIRAS family GTPase 2",TRUE
+"215506_s_at",0.502394860388381,0.0324092556571828,2.28254999315595,-3.67798220484937,1.31060905974507,"DIRAS3","DIRAS family GTPase 3",TRUE
+"1552674_at",0.806697551763868,0.347907666926528,0.958999556881979,-5.50140173150546,0.848701707794492,"DIRC1","disrupted in renal carcinoma 1",TRUE
+"229213_at",0.970540753946729,0.859889833045488,0.178580610778138,-5.92416246013638,0.0663019125884157,"DIRC2","disrupted in renal carcinoma 2",TRUE
+"226026_at",0.978255630670068,0.895008743216482,0.133492769001988,-5.93100758576653,0.0530161153582593,"DIRC2","disrupted in renal carcinoma 2",TRUE
+"232434_at",0.540215685291847,0.0446218634462856,-2.12886075354897,-3.94472214248519,-2.3030960165673,"DIRC3","disrupted in renal carcinoma 3",TRUE
+"218362_s_at",0.446963972064621,0.0211553451400074,2.48124658830031,-3.31731425576857,0.82420784448802,"DIS3","DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease",TRUE
+"236560_at",0.520046545647116,0.0376659226476923,2.21086880296227,-3.80380130348906,0.814284779919574,"DIS3","DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease",TRUE
+"222607_s_at",0.528768444275307,0.0411921097108818,2.16772743014886,-3.8783470297584,0.584564322615403,"DIS3","DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease",TRUE
+"214194_at",0.537690971752131,0.0436643422876902,2.13943242250967,-3.92674295160986,0.586689349208394,"DIS3","DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease",TRUE
+"234660_s_at",0.668403802227594,0.134536512912934,1.553229902988,-4.82834451131732,0.470324091766075,"DIS3","DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease",TRUE
+"235005_at",0.796963640275795,0.329803704929514,-0.99642138742561,-5.46733512942831,-0.316555374108914,"DIS3L","DIS3 like exosome 3'-5' exoribonuclease",TRUE
+"244304_at",0.682504456039784,0.14998038922066,-1.49131294908842,-4.91087722667177,-0.981714240419025,"DIS3L2","DIS3 like 3'-5' exoribonuclease 2",TRUE
+"242539_at",0.760439386481756,0.259352461164477,-1.15760486415154,-5.30725671360988,-0.661243383017682,"DIS3L2","DIS3 like 3'-5' exoribonuclease 2",TRUE
+"227597_at",0.816800680706682,0.36890409432381,0.917219794193521,-5.53802356446854,0.500678496417304,"DIS3L2","DIS3 like 3'-5' exoribonuclease 2",TRUE
+"238602_at",0.922551208973737,0.66894453918178,0.433357922847967,-5.84862511586293,0.105321836795316,"DIS3L2","DIS3 like 3'-5' exoribonuclease 2",TRUE
+"217330_at",0.714782078270721,0.190133516065023,-1.35162726202957,-5.08700862243385,-0.63060152156263,"DISC1","disrupted in schizophrenia 1",TRUE
+"233207_at",0.914777625972484,0.641127320346159,0.472590470741886,-5.83148353532612,0.327034728820539,"DISC1","disrupted in schizophrenia 1",TRUE
+"1563744_a_at",0.951934441578502,0.780125058488723,0.282575712959182,-5.90086662039993,0.153705615346816,"DISC1","disrupted in schizophrenia 1",TRUE
+"1557845_at",0.894737148770801,0.572054915956234,0.573540661344507,-5.78072225703409,0.45975797241846,"DISC1FP1","DISC1 fusion partner 1 (non-protein coding)",TRUE
+"228184_at",0.979588787486838,0.902454143222617,-0.123973406947816,-5.93220038137702,-0.0786027059047187,"DISP1","dispatched RND transporter family member 1",TRUE
+"229579_s_at",0.755940660414394,0.250559064593529,1.179885802995,-5.2834625845505,1.15906023488518,"DISP2","dispatched RND transporter family member 2",TRUE
+"230019_s_at",0.901781358899845,0.599096004417586,0.533357713988868,-5.80207020482263,0.332183562029792,"DISP3","dispatched RND transporter family member 3",TRUE
+"234355_s_at",0.954449231029359,0.790747426389396,0.26856732711425,-5.90461332626877,0.0858930649248562,"DISP3","dispatched RND transporter family member 3",TRUE
+"1558340_at",0.758189649141895,0.25500637384353,1.16854571886291,-5.29562244885657,0.679580510067678,"DIXDC1","DIX domain containing 1",TRUE
+"1558342_x_at",0.94895689004559,0.768240158423673,0.298317972894704,-5.89643068720386,0.187422985551027,"DIXDC1","DIX domain containing 1",TRUE
+"214724_at",0.957440336789825,0.808084897695533,-0.245819330380605,-5.91029442974551,-0.123944880653038,"DIXDC1","DIX domain containing 1",TRUE
+"216608_at",0.924812035112346,0.674694894146634,0.42533530224369,-5.85195091139637,0.351063682496839,"DKFZP434A062","uncharacterized LOC26102",TRUE
+"217219_at",0.963778983630888,0.834534767664145,-0.211364655578641,-5.91794732261641,-0.0741562678389203,"DKFZP434A062","uncharacterized LOC26102",TRUE
+"1565771_at",0.992126078367323,0.96340114773988,-0.0464075744866457,-5.93863456536127,-0.028319777764497,"DKFZp434E1119","uncharacterized DKFZp434E1119",TRUE
+"234905_at",0.883190352125328,0.541054871814262,0.620816143790582,-5.75368672495758,0.373913474957868,"DKFZP434H168","uncharacterized LOC26077",TRUE
+"234356_at",0.847797601020174,0.447331750330761,-0.773619692548058,-5.65231219492067,-0.259146770013419,"DKFZP434K028","uncharacterized LOC26070",TRUE
+"1554880_at",0.883515015273005,0.541808412383879,0.619650353913927,-5.75437824222025,0.445032757880642,"DKFZP434K028","uncharacterized LOC26070",TRUE
+"216596_at",0.748184017928985,0.240682072916056,1.20561961919116,-5.25548889997687,0.660450086418297,"DKFZP434L187","uncharacterized LOC26082",TRUE
+"1569476_at",0.841346844002252,0.431614153204963,0.80104171904386,-5.63189199327728,0.715081427329257,"DKFZP434L187","uncharacterized LOC26082",TRUE
+"230861_at",0.996224607226304,0.981160447474452,-0.0238820849371029,-5.93940568617195,-0.0179129098297102,"DKFZP434L187","uncharacterized LOC26082",TRUE
+"1553898_a_at",0.672434875127089,0.138409047229229,1.53717658854134,-4.84999911410608,1.06190283444143,"DKFZp434L192","uncharacterized protein DKFZp434L192",TRUE
+"1563511_at",0.662946889292072,0.130928221501158,1.56853510242123,-4.80753394239221,0.407486290838484,"DKFZp451B082","uncharacterized LOC401282",TRUE
+"1566624_at",0.79134298985948,0.321762158345973,1.01349919281935,-5.45139491997248,1.3811227765629,"DKFZP547J0410","DKFZP547J0410 protein",TRUE
+"1566623_at",0.930827859648584,0.693826403148027,0.398843519730807,-5.86249896430536,0.241016370930799,"DKFZP547J0410","DKFZP547J0410 protein",TRUE
+"234769_at",0.899500848552688,0.590289720092738,0.546343356383681,-5.79533597065608,0.259296811061037,"DKFZp547J222","uncharacterized LOC84237",TRUE
+"234771_at",0.948015976270656,0.763943662303632,-0.304027718707571,-5.89476285397911,-0.21293436659018,"DKFZp547J222","uncharacterized LOC84237",TRUE
+"1557398_at",0.117675054637733,0.000639222519019786,-3.97163678953839,-0.261847566445128,-2.11385570719521,"DKFZP564C152","DKFZP564C152 protein",TRUE
+"216028_at",0.737829808158124,0.224540469646878,-1.24944553867489,-5.20664680836211,-0.62418514872429,"DKFZP564C152","DKFZP564C152 protein",TRUE
+"234787_at",0.969270009913181,0.854174050895752,0.185952333037881,-5.92285570021689,0.14718694479272,"DKFZp564H213","uncharacterized LOC440432",TRUE
+"233869_x_at",0.900535738777606,0.595510059319321,0.538634185506888,-5.7993528721324,0.352930256259057,"DKFZP586B0319","DKFZP586B0319 protein",TRUE
+"213546_at",0.805859691692007,0.346201719953915,-0.962468149442429,-5.49829417529269,-0.515915350888701,"DKFZP586I1420","uncharacterized protein DKFZp586I1420",TRUE
+"234525_at",0.596382916302699,0.0727892660099571,1.88375296012558,-4.34497266281546,1.1891836565625,"DKFZP761C1711","uncharacterized protein DKFZp761C1711",TRUE
+"234480_at",0.94960065125426,0.772138956579083,-0.293145492290409,-5.89791451872272,-0.230826713345603,"DKFZP761C1711","uncharacterized protein DKFZp761C1711",TRUE
+"230115_at",0.88861610791789,0.55488326548559,0.599557672032475,-5.76609967542893,0.235665144169785,"DKFZp779M0652","uncharacterized DKFZp779M0652",TRUE
+"204602_at",0.676468346171966,0.143221038247713,1.51773608458904,-4.87598357745487,2.24315407160316,"DKK1","dickkopf WNT signaling pathway inhibitor 1",TRUE
+"224199_at",0.718706241731185,0.19440429549931,1.33819753616634,-5.10318541775088,0.931090811940477,"DKK2","dickkopf WNT signaling pathway inhibitor 2",TRUE
+"219908_at",0.826190015805964,0.394425455739685,0.868510311301813,-5.57881709906371,0.859907428688773,"DKK2","dickkopf WNT signaling pathway inhibitor 2",TRUE
+"202196_s_at",0.0723378272955723,0.000231533969395979,4.38624586377593,0.633602805633165,5.16976038294759,"DKK3","dickkopf WNT signaling pathway inhibitor 3",TRUE
+"214247_s_at",0.170374697680568,0.0014234966019026,3.64262067386988,-0.96783978066729,3.32102210248165,"DKK3","dickkopf WNT signaling pathway inhibitor 3",TRUE
+"221127_s_at",0.226811031406261,0.0028126131716323,3.35943238826918,-1.56692631301754,3.52810428787254,"DKK3","dickkopf WNT signaling pathway inhibitor 3",TRUE
+"230508_at",0.332566035407083,0.0081729879992852,2.90498005771233,-2.49895378759771,2.71838526964959,"DKK3","dickkopf WNT signaling pathway inhibitor 3",TRUE
+"221126_at",0.827060995001753,0.395824509487167,0.865900342969642,-5.58094463017315,0.556517489744017,"DKK3","dickkopf WNT signaling pathway inhibitor 3",TRUE
+"207875_at",0.957571530817866,0.80881732805155,0.244861327645587,-5.91052272273362,0.131530934792582,"DKK3","dickkopf WNT signaling pathway inhibitor 3",TRUE
+"206619_at",0.994050962712312,0.971932595483703,0.0355841456949945,-5.93906676492659,0.0381483035797379,"DKK4","dickkopf WNT signaling pathway inhibitor 4",TRUE
+"220284_at",0.796963640275795,0.329929760165598,-0.996155996722223,-5.46758090223771,-0.633771573875451,"DKKL1","dickkopf like acrosomal protein 1",TRUE
+"211150_s_at",0.789503009592599,0.316502355298273,1.02483099831913,-5.44068267119696,0.371095493894462,"DLAT","dihydrolipoamide S-acetyltransferase",TRUE
+"212568_s_at",0.896115372949367,0.57736601765857,0.56557483049952,-5.78507376343874,0.200476962845192,"DLAT","dihydrolipoamide S-acetyltransferase",TRUE
+"213149_at",0.899808883319249,0.593042259882791,0.542274381286579,-5.79746304427297,0.21938394909183,"DLAT","dihydrolipoamide S-acetyltransferase",TRUE
+"242631_x_at",0.593339168375633,0.0704465765324603,1.90057440187419,-4.3185703437328,1.49147945641034,"DLC1","DLC1 Rho GTPase activating protein",TRUE
+"220511_s_at",0.779252558608732,0.300455842487987,1.06024227506864,-5.40651625481315,0.290281111417004,"DLC1","DLC1 Rho GTPase activating protein",TRUE
+"220512_at",0.944988329745111,0.752412930201992,-0.319402992170651,-5.89011593278998,-0.269149568694409,"DLC1","DLC1 Rho GTPase activating protein",TRUE
+"210762_s_at",0.971735822349954,0.864841179874641,-0.172202982717185,-5.92525048792959,-0.237767190324722,"DLC1","DLC1 Rho GTPase activating protein",TRUE
+"224822_at",0.984082868807689,0.92178911830118,-0.0993049950602263,-5.93488145760017,-0.12251820047437,"DLC1","DLC1 Rho GTPase activating protein",TRUE
+"230426_at",0.928111156882231,0.684060784637223,0.412328678324027,-5.85721302728705,0.1550435181067,"DLD","dihydrolipoamide dehydrogenase",TRUE
+"209095_at",0.989526408130298,0.948986140106304,0.064708799973819,-5.9376442417593,0.0172569435609784,"DLD","dihydrolipoamide dehydrogenase",TRUE
+"206798_x_at",0.713633547141264,0.188562080007148,1.35662847391504,-5.08094986572641,0.768816102862952,"DLEC1","deleted in lung and esophageal cancer 1",TRUE
+"215085_x_at",0.9202957869034,0.660896091028351,-0.444635618218617,-5.84384675882204,-0.233019970150039,"DLEC1","deleted in lung and esophageal cancer 1",TRUE
+"207896_s_at",0.98529096111871,0.926677528962614,0.0930787472942793,-5.93546461551154,0.02418630536831,"DLEC1","deleted in lung and esophageal cancer 1",TRUE
+"205677_s_at",0.756313947022433,0.251356803306994,1.17784069331548,-5.28566312266423,0.452478544631719,"DLEU1","deleted in lymphocytic leukemia 1",TRUE
+"216856_s_at",0.615637099066718,0.0858698176879746,1.79768491840164,-4.47744596985692,1.68603765137181,"DLEU2","deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"1564443_at",0.800907918330069,0.336859237437705,0.981673472955037,-5.48090258799012,0.350319847343097,"DLEU2","deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"1569600_at",0.878278790222455,0.530985017902334,0.636479435533847,-5.74427432204271,0.48805095593302,"DLEU2","deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"1556820_a_at",0.88782282220852,0.553108106056728,0.602270896302232,-5.7645386426176,0.33610182075426,"DLEU2","deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"216870_x_at",0.904832003218088,0.610126862120845,0.517221341696557,-5.81021867747388,0.312410769604234,"DLEU2","deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"1556821_x_at",0.919372089675945,0.657065831384284,0.450023230831123,-5.84152151807661,0.280407461047496,"DLEU2","deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"242854_x_at",0.933548873991014,0.705837518072875,0.382359894525035,-5.86872508210901,0.307738697874475,"DLEU2","deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"1566081_at",0.682825347106105,0.151017624146861,1.48734472944458,-4.91607505476964,0.891076783329285,"DLEU7","deleted in lymphocytic leukemia, 7",TRUE
+"1569987_at",0.78065889313777,0.302351557295277,1.05599008256818,-5.41067405958002,0.462141948956089,"DLEU7-AS1","DLEU7 antisense RNA 1",TRUE
+"217208_s_at",0.423421354964585,0.0178274523846086,2.55925987031191,-3.17130971290763,1.30573760224872,"DLG1","discs large MAGUK scaffold protein 1",TRUE
+"202515_at",0.56258150702388,0.055121154698252,2.024646800655,-4.11887906583469,0.697151444638283,"DLG1","discs large MAGUK scaffold protein 1",TRUE
+"230229_at",0.575986890549489,0.0611116396510202,1.97289828714765,-4.20320925872463,0.990936398073995,"DLG1","discs large MAGUK scaffold protein 1",TRUE
+"202516_s_at",0.605913415325856,0.079295330673512,1.83940041266141,-4.41379134894912,0.693979769032621,"DLG1","discs large MAGUK scaffold protein 1",TRUE
+"202514_at",0.61760967235709,0.0882047986987133,1.78353257799716,-4.49880097442134,0.62654257164383,"DLG1","discs large MAGUK scaffold protein 1",TRUE
+"229703_at",0.640839095542136,0.111323796908705,1.6584215809814,-4.68212125206304,0.632605313010709,"DLG1","discs large MAGUK scaffold protein 1",TRUE
+"215988_s_at",0.806221445484273,0.346908865587734,-0.961028947893772,-5.49958481945022,-0.407088227723217,"DLG1","discs large MAGUK scaffold protein 1",TRUE
+"1556518_at",0.48580305784244,0.0285271934717675,2.34267684378385,-3.57063103197052,1.50027334827962,"DLG1-AS1","DLG1 antisense RNA 1",TRUE
+"206253_at",0.8920930097751,0.564206380595737,-0.585381446710656,-5.77414506907506,-0.441687629839716,"DLG2","discs large MAGUK scaffold protein 2",TRUE
+"228973_at",0.957571530817866,0.808658142889513,-0.245069518370542,-5.91047318605456,-0.198405901852589,"DLG2","discs large MAGUK scaffold protein 2",TRUE
+"212727_at",0.554642754132296,0.0511572264633104,-2.06171607389472,-4.05758184142198,-0.888608764203459,"DLG3","discs large MAGUK scaffold protein 3",TRUE
+"212728_at",0.571830403845452,0.0598535097487905,-1.98338106167196,-4.18624491963126,-1.10148509000085,"DLG3","discs large MAGUK scaffold protein 3",TRUE
+"212729_at",0.700633137129073,0.172430218357822,-1.40997742314211,-5.01516432744397,-0.678330632898343,"DLG3","discs large MAGUK scaffold protein 3",TRUE
+"207732_s_at",0.786796445263724,0.312459281499977,-1.03363153990763,-5.43228910834403,-0.456334660958699,"DLG3","discs large MAGUK scaffold protein 3",TRUE
+"241839_at",0.845442858996867,0.442384150887514,0.782187017778873,-5.64600438515138,0.451999038724161,"DLG3-AS1","DLG3 antisense RNA 1",TRUE
+"204592_at",0.941317445464466,0.737490152609343,0.33941917032008,-5.88372644090848,0.337146038337442,"DLG4","discs large MAGUK scaffold protein 4",TRUE
+"210684_s_at",0.983303501876831,0.918595207414045,-0.103375157899764,-5.93447985801981,-0.0663652298460882,"DLG4","discs large MAGUK scaffold protein 4",TRUE
+"210469_at",0.968451827985008,0.851885213986104,0.188907213102502,-5.92231710954171,0.0857426745951289,"DLG5","discs large MAGUK scaffold protein 5",TRUE
+"201681_s_at",0.990888965463429,0.956980355415289,0.0545569948493528,-5.93823385803526,0.0219136759020735,"DLG5","discs large MAGUK scaffold protein 5",TRUE
+"1562598_at",0.70933660268743,0.182116266434182,1.37749358191489,-5.05547146854833,0.45716495214777,"DLG5-AS1","DLG5 antisense RNA 1",TRUE
+"239565_at",0.974884920935236,0.877337556140259,-0.15613873757569,-5.92781619131019,-0.0771146888785257,"DLG5-AS1","DLG5 antisense RNA 1",TRUE
+"206490_at",0.68806049531767,0.157472931778056,1.46313448372493,-4.94754493238848,0.803392408533513,"DLGAP1","DLG associated protein 1",TRUE
+"1560773_at",0.885029460971826,0.545465029966154,0.614005487117623,-5.7577089155812,0.640795532795018,"DLGAP1","DLG associated protein 1",TRUE
+"235527_at",0.910165867297668,0.62673979386465,0.49317746527364,-5.82190736610591,0.525366265322366,"DLGAP1","DLG associated protein 1",TRUE
+"210750_s_at",0.931370027472813,0.695756536866809,0.396187198040961,-5.86351979354342,0.281040040897363,"DLGAP1","DLG associated protein 1",TRUE
+"1568735_at",0.942303845415102,0.74071216222283,-0.335085733423588,-5.88514232472052,-0.292111804585945,"DLGAP1","DLG associated protein 1",TRUE
+"1568736_s_at",0.961644868810744,0.826196727343684,0.222195901419111,-5.91566524662097,0.198934534648795,"DLGAP1","DLG associated protein 1",TRUE
+"206489_s_at",0.993213867476782,0.967528247184001,-0.0411710985012965,-5.9388579135589,-0.0345656624210071,"DLGAP1","DLG associated protein 1",TRUE
+"238432_at",0.54295328972902,0.0457298942630645,2.11687954761692,-3.96503029577438,1.42523102771566,"DLGAP1-AS1","DLGAP1 antisense RNA 1",TRUE
+"239421_at",0.848075167668129,0.447699928018385,0.772984462966685,-5.65277728131088,0.49966408983917,"DLGAP1-AS1","DLGAP1 antisense RNA 1",TRUE
+"1560019_at",0.152865811663982,0.00112114815760793,3.74108223460349,-0.757405733450534,3.62012968585357,"DLGAP1-AS2","DLGAP1 antisense RNA 2",TRUE
+"223974_at",0.345823377376834,0.00883612726466278,2.87101528093818,-2.56664247004193,3.07072810890071,"DLGAP1-AS2","DLGAP1 antisense RNA 2",TRUE
+"1560522_at",0.597654932724127,0.075051097529446,-1.86795543180702,-4.36961759863996,-1.25950686092432,"DLGAP1-AS3","DLGAP1 antisense RNA 3",TRUE
+"216916_s_at",0.605913415325856,0.0794521409204648,1.83837110290815,-4.41537460546956,0.599431368262144,"DLGAP2","DLG associated protein 2",TRUE
+"210227_at",0.729789891627758,0.21208236795913,-1.2849451301009,-5.1659877971897,-0.878742544122506,"DLGAP2","DLG associated protein 2",TRUE
+"1564421_at",0.936992192746977,0.718967162082649,-0.364463640485289,-5.87519134818553,-0.118329494775548,"DLGAP2-AS1","DLGAP2 antisense RNA 1",TRUE
+"231151_at",0.825277018878999,0.392702696901153,-0.871732397893956,-5.57618238796202,-0.415549003605669,"DLGAP3","DLG associated protein 3",TRUE
+"202570_s_at",0.695812999227098,0.165746882054751,-1.43325153355445,-4.98580978142624,-0.641999296068381,"DLGAP4","DLG associated protein 4",TRUE
+"233056_x_at",0.725181883744124,0.203810756574118,-1.3094139882483,-5.13739861298596,-0.347333228194698,"DLGAP4","DLG associated protein 4",TRUE
+"202572_s_at",0.740270784944871,0.228776404963166,-1.23771890780309,-5.2198629941533,-0.453092816788908,"DLGAP4","DLG associated protein 4",TRUE
+"1556701_at",0.87579870142401,0.523456938983435,0.648294472964804,-5.73702523960652,0.53197100540852,"DLGAP4","DLG associated protein 4",TRUE
+"1557394_at",0.976660494182006,0.88887018104541,-0.141350738408304,-5.92995662718556,-0.095110430619135,"DLGAP4","DLG associated protein 4",TRUE
+"202571_s_at",0.980251716625976,0.907407405246893,-0.117646932034885,-5.93294438475483,-0.041789249369014,"DLGAP4","DLG associated protein 4",TRUE
+"1558630_at",0.470885186348082,0.0255305960221347,2.39447949143942,-3.47687095118932,0.830022467107887,"DLGAP4-AS1","DLGAP4 antisense RNA 1",TRUE
+"203764_at",0.727318639756418,0.207748667403068,1.29767082914508,-5.15117631640536,0.471530793756536,"DLGAP5","DLG associated protein 5",TRUE
+"209560_s_at",0.902268042923638,0.601062724886764,-0.530470322802208,-5.80354616631389,-0.194587594502188,"DLK1","delta like non-canonical Notch ligand 1",TRUE
+"235600_at",0.956619372543067,0.803128156283812,0.252308872734763,-5.90872463296251,0.117729897500587,"DLK1","delta like non-canonical Notch ligand 1",TRUE
+"220262_s_at",0.308861881799719,0.00647671851614754,3.00557594922903,-2.29666353865275,2.97635265071515,"DLK2","delta like non-canonical Notch ligand 2",TRUE
+"227938_s_at",0.673622120503302,0.139946410939317,1.5309060465545,-4.85840913273555,1.05456336106275,"DLL1","delta like canonical Notch ligand 1",TRUE
+"224215_s_at",0.956960361976289,0.804773711785387,-0.250153238704411,-5.90925058258018,-0.488707082808677,"DLL1","delta like canonical Notch ligand 1",TRUE
+"229755_x_at",0.658590024406624,0.126839560256091,1.58630631815874,-4.78316958733512,0.859221412162732,"DLL3","delta like canonical Notch ligand 3",TRUE
+"219537_x_at",0.820536502908875,0.380505235910233,0.894812690427876,-5.55704502836169,0.680642678658161,"DLL3","delta like canonical Notch ligand 3",TRUE
+"222898_s_at",0.888750194607196,0.555426260556026,-0.598728643479653,-5.76657529285577,-0.416059842246611,"DLL3","delta like canonical Notch ligand 3",TRUE
+"230568_x_at",0.954577684533304,0.792909071330991,0.265723432613167,-5.90535086482065,0.122664386535159,"DLL3","delta like canonical Notch ligand 3",TRUE
+"223525_at",0.853399486996397,0.461701999549217,-0.74905662682272,-5.67003310013992,-0.553034892511465,"DLL4","delta like canonical Notch ligand 4",TRUE
+"215210_s_at",0.946727564264032,0.758560333884247,0.311196403605487,-5.8926244928512,0.113550053493045,"DLST","dihydrolipoamide S-succinyltransferase",TRUE
+"1560100_at",0.935414597731663,0.712813678805451,0.372835640481164,-5.87220444392969,0.404676880075312,"DLX1","distal-less homeobox 1",TRUE
+"242138_at",0.988737747949649,0.945824630878144,-0.0687254440552387,-5.93738325248776,-0.089914075135411,"DLX1","distal-less homeobox 1",TRUE
+"207147_at",0.954614142466984,0.793074691318522,0.265505632938321,-5.90540702774331,0.317742321010802,"DLX2","distal-less homeobox 2",TRUE
+"215685_s_at",0.998347572104896,0.991947013562878,0.0102075933515349,-5.93963273135214,0.00464353004633544,"DLX2","distal-less homeobox 2",TRUE
+"231778_at",0.970353888480813,0.858927487946988,-0.179821040197705,-5.92394626020221,-0.196729436773269,"DLX3","distal-less homeobox 3",TRUE
+"208216_at",0.873330973137109,0.518453296635319,0.656199067356992,-5.7321039309655,0.277003197399053,"DLX4","distal-less homeobox 4",TRUE
+"210259_s_at",0.94333312187812,0.745780963752752,-0.328281640752304,-5.88732913860512,-0.139558722955146,"DLX4","distal-less homeobox 4",TRUE
+"213707_s_at",0.894563570028521,0.571257901205192,0.574739288596687,-5.78006237723726,0.89495711754236,"DLX5","distal-less homeobox 5",TRUE
+"239309_at",0.68033297785336,0.147813203725332,1.49967684830542,-4.89988522029802,1.68924517598323,"DLX6","distal-less homeobox 6",TRUE
+"242940_x_at",0.712148529314333,0.186256462413918,1.36402608106859,-5.0719537234722,1.92944365657951,"DLX6","distal-less homeobox 6",TRUE
+"221289_at",0.988948717228281,0.946593294404974,0.0677487660020911,-5.93744815922971,0.0720017563606845,"DLX6","distal-less homeobox 6",TRUE
+"230882_at",0.73223722457785,0.216150291402283,1.27318130414551,-5.17956916509607,0.980998936621201,"DLX6-AS1","DLX6 antisense RNA 1",TRUE
+"224163_s_at",0.920177077739411,0.660423753224915,-0.445299279351664,-5.84356181278748,-0.230960377315878,"DMAP1","DNA methyltransferase 1 associated protein 1",TRUE
+"208250_s_at",0.525405708458677,0.0392745906855916,2.19075219265609,-3.83867405030452,1.04494015700165,"DMBT1","deleted in malignant brain tumors 1",TRUE
+"234776_at",0.7994347047598,0.334835665871285,-0.985881314065435,-5.47705031627452,-0.81957428447829,"DMBX1","diencephalon/mesencephalon homeobox 1",TRUE
+"208386_x_at",0.983935461205724,0.921332279626118,0.0998870608224873,-5.93482501308749,0.0400302988645089,"DMC1","DNA meiotic recombinase 1",TRUE
+"208382_s_at",0.991367768700244,0.959658881975121,-0.0511569182190134,-5.93840890217274,-0.0480507892145532,"DMC1","DNA meiotic recombinase 1",TRUE
+"208086_s_at",0.457032025390949,0.0225631473871043,2.45164311622345,-3.37209657100431,2.43496661560034,"DMD","dystrophin",TRUE
+"203881_s_at",0.556381379241158,0.051671919109895,2.05676083925025,-4.06581798082417,2.65375612285411,"DMD","dystrophin",TRUE
+"207660_at",0.677509122383198,0.145081737354842,1.51036236068127,-4.88577043573171,0.843579765916148,"DMD","dystrophin",TRUE
+"234752_x_at",0.682539393883246,0.150365537243674,1.48983686025966,-4.91281200360782,1.50364847833619,"DMD","dystrophin",TRUE
+"231790_at",0.753445799992783,0.246669955553193,1.18992628631051,-5.27261071298317,1.14953438071144,"DMGDH","dimethylglycine dehydrogenase",TRUE
+"231591_at",0.868771271118463,0.50509174016523,0.677516943073661,-5.71854678505432,0.645324460939105,"DMGDH","dimethylglycine dehydrogenase",TRUE
+"226926_at",0.683019114815084,0.152072147493421,1.48333305488935,-4.92131846787374,1.25985703672615,"DMKN","dermokine",TRUE
+"208175_s_at",0.860714927752408,0.480582019421225,0.717467682712519,-5.69202568148036,0.66239945545547,"DMP1","dentin matrix acidic phosphoprotein 1",TRUE
+"217067_s_at",0.930820302962216,0.69324892480284,-0.399638833902873,-5.86219201686985,-0.346888583850186,"DMP1","dentin matrix acidic phosphoprotein 1",TRUE
+"217066_s_at",0.614178202960275,0.08510826036438,-1.80237256969841,-4.47034557111265,-1.76701206412266,"DMPK","dystrophia myotonica protein kinase",TRUE
+"217062_at",0.635368778245437,0.106216572490721,1.68401331149456,-4.64543677500864,0.524860321751574,"DMPK","dystrophia myotonica protein kinase",TRUE
+"37996_s_at",0.726535590042475,0.205609239775532,-1.30402911087689,-5.14372949232348,-0.855208326001852,"DMPK","dystrophia myotonica protein kinase",TRUE
+"220493_at",0.993225426079816,0.968048585049757,-0.0405109791223678,-5.93888417385372,-0.0240355802325292,"DMRT1","doublesex and mab-3 related transcription factor 1",TRUE
+"223986_x_at",0.887044556660952,0.551229134319226,0.605147767416159,-5.76287602380884,0.527020054252446,"DMRT2","doublesex and mab-3 related transcription factor 2",TRUE
+"223704_s_at",0.906507435035949,0.614581499423987,0.510744377724651,-5.81342078550329,0.46284753886437,"DMRT2","doublesex and mab-3 related transcription factor 2",TRUE
+"231800_s_at",0.7994347047598,0.334630173129028,-0.986309596346326,-5.47665738366139,-0.841030231560931,"DMRT3","doublesex and mab-3 related transcription factor 3",TRUE
+"233930_at",0.923494952314901,0.671770557130813,0.429411618047173,-5.85026869454515,0.260824451028905,"DMRT3","doublesex and mab-3 related transcription factor 3",TRUE
+"244725_at",0.835838027302116,0.415395221843715,0.8299951532779,-5.60960681686355,0.302499414520854,"DMRTA1","DMRT like family A1",TRUE
+"1558856_at",0.615821255316333,0.0867055611820327,1.79258175235151,-4.48516048559136,1.20677970359425,"DMRTA2","DMRT like family A2",TRUE
+"240313_at",0.880471324868787,0.535886478766254,0.628835605790449,-5.748895860689,0.312916857337367,"DMRTB1","DMRT like family B with proline rich C-terminal 1",TRUE
+"1560300_a_at",0.662575055303091,0.13025505576736,1.57142902465941,-4.80358103390165,0.466243794022699,"DMRTC1B///DMRTC1","DMRT like family C1B///DMRT like family C1",TRUE
+"1553998_at",0.792436690618566,0.323866496408929,-1.00900180366295,-5.45561653902083,-0.508863935470012,"DMRTC1B///DMRTC1","DMRT like family C1B///DMRT like family C1",TRUE
+"236811_at",0.556381379241158,0.0517721430686203,2.05580106337661,-4.06741173555185,1.5725752648258,"DMRTC2","DMRT like family C2",TRUE
+"203301_s_at",0.910165867297668,0.626826819399354,-0.493052298310865,-5.82196679383518,-0.133914689632523,"DMTF1","cyclin D binding myb like transcription factor 1",TRUE
+"204505_s_at",0.636147339487472,0.107614864213975,1.67690494449697,-4.65566900235739,1.32204570895154,"DMTN","dematin actin binding protein",TRUE
+"1554429_a_at",0.875938621758472,0.524161427941902,-0.647184884119254,-5.7377114739588,-0.225352456128995,"DMWD","dystrophia myotonica, WD repeat containing",TRUE
+"213231_at",0.897401619272848,0.58402252902644,0.555642963135266,-5.79041658142146,0.231395815459768,"DMWD","dystrophia myotonica, WD repeat containing",TRUE
+"33768_at",0.932091525948902,0.700038371684922,0.390304686605574,-5.86575653409548,0.123440423864828,"DMWD","dystrophia myotonica, WD repeat containing",TRUE
+"203791_at",0.925091998149497,0.675941597893472,-0.423599715847532,-5.8526623686119,-0.211437751934998,"DMXL1","Dmx like 1",TRUE
+"241472_at",0.986482025143628,0.937299644198246,0.0795622643996787,-5.93660076642751,0.0446404759765713,"DMXL1","Dmx like 1",TRUE
+"215761_at",0.565043084457947,0.0562861215880022,2.01420445828119,-4.13601357442504,1.18168521709427,"DMXL2","Dmx like 2",TRUE
+"212820_at",0.920919073017905,0.663600724988741,0.440839348294393,-5.84546868987927,0.22768648893552,"DMXL2","Dmx like 2",TRUE
+"213647_at",0.945820394457833,0.755403814251353,0.315407496879526,-5.89134533929773,0.111277004982663,"DNA2","DNA replication helicase/nuclease 2",TRUE
+"222068_s_at",0.64513208805899,0.11599824183299,-1.63585222757544,-4.71411740644014,-1.19727700542351,"DNAAF1","dynein axonemal assembly factor 1",TRUE
+"215173_at",0.686998148149102,0.155675298730766,1.46979422947827,-4.93892984154594,0.864129115991245,"DNAAF1","dynein axonemal assembly factor 1",TRUE
+"219166_at",0.703902004301726,0.175604880803587,-1.39917402336426,-5.02865574061044,-0.692944206823395,"DNAAF2","dynein axonemal assembly factor 2",TRUE
+"230033_at",0.823074246722209,0.389285000690291,-0.878151762392803,-5.57090624485936,-0.5415797049278,"DNAAF3","dynein axonemal assembly factor 3",TRUE
+"218460_at",0.853460708803218,0.462068398490512,0.748436384411935,-5.67047356737204,0.266191841542959,"DNAAF5","dynein axonemal assembly factor 5",TRUE
+"1554761_a_at",0.854400503339099,0.465675903160028,0.742345161806878,-5.67478089759398,0.308689046359206,"DNAAF5","dynein axonemal assembly factor 5",TRUE
+"1562278_at",0.55937703282623,0.0533066114279673,2.04131004024286,-4.09141549356029,1.22148221651419,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"228112_at",0.593339168375633,0.0704674625236081,1.90042228153667,-4.31880984138809,0.956288746168676,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"228111_s_at",0.595019326272843,0.0718222792112058,-1.89063803687442,-4.33418596790184,-1.45362668747688,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"242591_at",0.622917527985155,0.0936528001574102,1.75172600018936,-4.54634389882688,1.21287728609258,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"1558769_s_at",0.678624220305987,0.146241543476316,1.50580526986108,-4.89179983346523,0.812096697229362,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"1567376_at",0.679594284947055,0.146931578278174,1.50310800198375,-4.89536166452853,0.585033041786474,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"239059_at",0.763044089435492,0.262800796803815,1.14902019739229,-5.31631817977369,0.85298471616345,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"1567378_x_at",0.802679132489125,0.340419983925923,0.974311175476298,-5.4876066440436,0.523848927303103,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"232005_at",0.831875452294783,0.407246190740714,0.844811622139331,-5.59791643344607,0.279585939862235,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"1567377_at",0.87579870142401,0.523544073366227,-0.648157189647464,-5.73711020479357,-0.451463316213449,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"1566776_at",0.882535454326918,0.540174649822593,0.622179018921944,-5.7528767140349,0.445637332368984,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"1558768_at",0.9202957869034,0.660814069062422,-0.444750849123147,-5.84379731380278,-0.281310473975303,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"1566775_at",0.932625096890813,0.702435370167377,0.387017742898041,-5.86699198852352,0.198029335214319,"DNAH1","dynein axonemal heavy chain 1",TRUE
+"229738_at",0.675447258877226,0.141772614034824,1.5235305677097,-4.86826611492433,1.18690272267643,"DNAH10","dynein axonemal heavy chain 10",TRUE
+"1562462_at",0.714590421965913,0.190020815000272,1.35198485579075,-5.08657603382257,0.476620273863406,"DNAH10","dynein axonemal heavy chain 10",TRUE
+"1565339_at",0.940923956317617,0.735357670845025,0.342290892051839,-5.88277823806531,0.195080427443265,"DNAH10","dynein axonemal heavy chain 10",TRUE
+"237804_at",0.810375880424165,0.354375586575865,-0.945952603508491,-5.51299867160113,-0.946396849718147,"DNAH11","dynein axonemal heavy chain 11",TRUE
+"1560416_at",0.865733085695438,0.495831108284718,0.69247854331931,-5.70878440387294,0.70127225813415,"DNAH11","dynein axonemal heavy chain 11",TRUE
+"1553159_at",0.962555471240652,0.829235792935099,0.218245027875008,-5.91651082106289,0.167652226030935,"DNAH11","dynein axonemal heavy chain 11",TRUE
+"243802_at",0.893596416413622,0.568502199332994,0.578890153285453,-5.77776689370342,0.180332508991705,"DNAH12","dynein axonemal heavy chain 12",TRUE
+"1563097_at",0.947778780715578,0.762068347454026,0.306523108581528,-5.89402410221741,0.239339652562962,"DNAH12","dynein axonemal heavy chain 12",TRUE
+"242283_at",0.722937902375896,0.199352997648688,1.32292232574546,-5.1214201767993,0.462483734597219,"DNAH14","dynein axonemal heavy chain 14",TRUE
+"1567861_at",0.794620886196317,0.326772887208436,-1.00282359447258,-5.46138817213091,-0.92907426028071,"DNAH14","dynein axonemal heavy chain 14",TRUE
+"1554540_at",0.937257436560633,0.721656509911135,-0.360813054405003,-5.87647281210003,-0.30781971348219,"DNAH14","dynein axonemal heavy chain 14",TRUE
+"1567862_at",0.946579549170519,0.758047317283427,-0.311880423152243,-5.89241787497218,-0.317802026613046,"DNAH14","dynein axonemal heavy chain 14",TRUE
+"214229_at",0.812302873476553,0.360618979681314,-0.93351018539851,-5.5239225079065,-0.632160624910227,"DNAH17","dynein axonemal heavy chain 17",TRUE
+"1553470_at",0.916367073552623,0.646862134499561,0.464442482157419,-5.8351632707446,0.210467430438734,"DNAH17","dynein axonemal heavy chain 17",TRUE
+"1569925_at",0.830635993561085,0.40430293792288,0.850209342279429,-5.59360958454645,0.457267106368099,"DNAH17-AS1","DNAH17 antisense RNA 1",TRUE
+"215840_at",0.528176582660474,0.0407029812693316,2.17350693211085,-3.86841301026162,0.983610977979672,"DNAH2","dynein axonemal heavy chain 2",TRUE
+"239499_at",0.536422380101288,0.0433062347648301,2.14343995820054,-3.91991268234618,1.59343810993389,"DNAH2","dynein axonemal heavy chain 2",TRUE
+"216415_at",0.778291838199375,0.297793603203126,1.06624621683635,-5.40062008628958,0.743803768829835,"DNAH3","dynein axonemal heavy chain 3",TRUE
+"1560803_at",0.84421131646729,0.440846246863837,0.784861983020291,-5.64402149050052,0.513912601968378,"DNAH3","dynein axonemal heavy chain 3",TRUE
+"1563290_at",0.863832858913113,0.489629533931406,-0.702587079238919,-5.70207341494585,-0.357224560062481,"DNAH3","dynein axonemal heavy chain 3",TRUE
+"215266_at",0.863918945062466,0.490102051435624,-0.701814302399427,-5.70258973083699,-0.454145516698841,"DNAH3","dynein axonemal heavy chain 3",TRUE
+"220725_x_at",0.962741248200658,0.830238674808117,-0.216942034707665,-5.91678637921305,-0.0621837181141167,"DNAH3","dynein axonemal heavy chain 3",TRUE
+"243938_x_at",0.411110107932987,0.0162535177326397,2.6010303457734,-3.09219590398936,2.27085574068874,"DNAH5","dynein axonemal heavy chain 5",TRUE
+"232381_s_at",0.491058836532701,0.0293871881689071,2.32873595117347,-3.59566459717942,0.930768364183208,"DNAH5","dynein axonemal heavy chain 5",TRUE
+"1552957_at",0.539609110035715,0.0442893349146467,-2.13250870479382,-3.93852444464295,-1.55943392439885,"DNAH6","dynein axonemal heavy chain 6",TRUE
+"1565338_x_at",0.623503825356688,0.0945463132483304,1.74666188976748,-4.55385534220813,1.15917321272149,"DNAH6","dynein axonemal heavy chain 6",TRUE
+"234893_s_at",0.710657275720264,0.183547496653929,1.3728108325662,-5.06121774847474,0.79900476201601,"DNAH6","dynein axonemal heavy chain 6",TRUE
+"1565337_at",0.741260241503758,0.231782206376455,-1.22949760099092,-5.22906457585998,-0.85778806158295,"DNAH6","dynein axonemal heavy chain 6",TRUE
+"215341_at",0.753931998274535,0.247339337047103,1.18818975639174,-5.27449330908509,0.530726272993625,"DNAH6","dynein axonemal heavy chain 6",TRUE
+"1561616_a_at",0.848092251929776,0.447724458339297,0.772942151243119,-5.65280824723397,0.473076328382767,"DNAH6","dynein axonemal heavy chain 6",TRUE
+"1553362_at",0.855075448726859,0.46725080556149,0.739694755688785,-5.67664467931344,0.908201298924646,"DNAH6","dynein axonemal heavy chain 6",TRUE
+"1561617_at",0.942502815705589,0.741718182817186,-0.333734030872385,-5.88558029044442,-0.202570258612839,"DNAH6","dynein axonemal heavy chain 6",TRUE
+"234727_at",0.851733415458562,0.456587695835602,0.757745062481895,-5.66382667206279,0.477694771808849,"DNAH7","dynein axonemal heavy chain 7",TRUE
+"214222_at",0.871744769522775,0.513815823499298,-0.663562912972028,-5.72746782359843,-0.358274177978974,"DNAH7","dynein axonemal heavy chain 7",TRUE
+"234476_at",0.976433695486417,0.888181208989733,0.142233250857053,-5.9298348496644,0.0410770543273955,"DNAH7","dynein axonemal heavy chain 7",TRUE
+"233052_at",0.774230543658252,0.288267552429041,1.08804950940352,-5.37895793377068,0.343417478945597,"DNAH8","dynein axonemal heavy chain 8",TRUE
+"240857_at",0.865200722711812,0.494481795762208,0.694671728253632,-5.7073362463471,0.566732176487131,"DNAH9","dynein axonemal heavy chain 9",TRUE
+"207959_s_at",0.930708572679794,0.693058214789808,0.399901540964391,-5.86209049413093,0.175324277101611,"DNAH9","dynein axonemal heavy chain 9",TRUE
+"210345_s_at",0.953104604277517,0.784779445449831,0.27643073847004,-5.90253344296326,0.194829090421778,"DNAH9","dynein axonemal heavy chain 9",TRUE
+"233195_at",0.768852835478002,0.272517487327041,1.1252685244002,-5.34107928327586,0.307885277421989,"DNAI1","dynein axonemal intermediate chain 1",TRUE
+"220125_at",0.93928706246326,0.728151479515414,-0.352017077051852,-5.87950812204947,-0.237900911183602,"DNAI1","dynein axonemal intermediate chain 1",TRUE
+"220636_at",0.327864702134751,0.00772981460609847,2.92917931740981,-2.45053369606686,1.51844255769939,"DNAI2","dynein axonemal intermediate chain 2",TRUE
+"221668_s_at",0.995618448898906,0.979102199550003,0.0264918432829462,-5.93934165697497,0.0112733633973137,"DNAI2","dynein axonemal intermediate chain 2",TRUE
+"200880_at",0.805746717966166,0.34524425792669,-0.964419994682903,-5.49654098323187,-0.374400482572481,"DNAJA1","DnaJ heat shock protein family (Hsp40) member A1",TRUE
+"200881_s_at",0.956734254923335,0.804018608384209,-0.25114225308765,-5.90900983145195,-0.072004813832498,"DNAJA1","DnaJ heat shock protein family (Hsp40) member A1",TRUE
+"209157_at",0.780614263830306,0.302160388355724,-1.05641802352763,-5.41025629617523,-0.339065402861699,"DNAJA2","DnaJ heat shock protein family (Hsp40) member A2",TRUE
+"226994_at",0.796466121438385,0.329260446241088,-0.997565942566149,-5.46627449965738,-0.42381879496034,"DNAJA2","DnaJ heat shock protein family (Hsp40) member A2",TRUE
+"1554078_s_at",0.332566035407083,0.00818526691155619,-2.904327588161,-2.50025710701705,-0.737752890985986,"DNAJA3","DnaJ heat shock protein family (Hsp40) member A3",TRUE
+"205963_s_at",0.474859593446097,0.0261213204472949,-2.38383884304845,-3.4962236890079,-0.651530733824794,"DNAJA3","DnaJ heat shock protein family (Hsp40) member A3",TRUE
+"1554333_at",0.75235436509186,0.24569680865828,1.19245715896308,-5.26986267025093,1.63445788801942,"DNAJA4","DnaJ heat shock protein family (Hsp40) member A4",TRUE
+"1554334_a_at",0.768852835478002,0.272246107588314,1.12592338772601,-5.34040270997886,1.07741768677001,"DNAJA4","DnaJ heat shock protein family (Hsp40) member A4",TRUE
+"225061_at",0.774230543658252,0.28952675511472,1.08513803702079,-5.38187320274237,1.18212199173205,"DNAJA4","DnaJ heat shock protein family (Hsp40) member A4",TRUE
+"220395_at",0.982462634157412,0.915274488966844,-0.10760881682095,-5.93404502991784,-0.032508542607081,"DNAJA4","DnaJ heat shock protein family (Hsp40) member A4",TRUE
+"200664_s_at",0.700061364939874,0.171387554304093,1.41356027712225,-5.01067114855408,0.632292886890163,"DNAJB1","DnaJ heat shock protein family (Hsp40) member B1",TRUE
+"200666_s_at",0.707898177720919,0.179682462549321,1.38552401545206,-5.04557937949814,0.511266581821021,"DNAJB1","DnaJ heat shock protein family (Hsp40) member B1",TRUE
+"223054_at",0.968451827985008,0.851728982457193,0.189108969891906,-5.92228002639538,0.0672606242588376,"DNAJB11","DnaJ heat shock protein family (Hsp40) member B11",TRUE
+"214338_at",0.821152021021234,0.382198017941442,0.89158096033286,-5.55975256067934,0.291714911498135,"DNAJB12","DnaJ heat shock protein family (Hsp40) member B12",TRUE
+"202866_at",0.943464796017993,0.746560857916604,-0.327236161670969,-5.88766121766809,-0.097502234798176,"DNAJB12","DnaJ heat shock protein family (Hsp40) member B12",TRUE
+"202865_at",0.94895689004559,0.768388852381553,-0.298120551158904,-5.89648779399757,-0.0986559994082254,"DNAJB12","DnaJ heat shock protein family (Hsp40) member B12",TRUE
+"202867_s_at",0.986342822130003,0.934341028468094,0.0833254226305321,-5.93630230577144,0.030335906467819,"DNAJB12","DnaJ heat shock protein family (Hsp40) member B12",TRUE
+"230936_at",0.753496602993995,0.246727932023804,1.18977574253622,-5.27277401440967,0.413817522201206,"DNAJB13","DnaJ heat shock protein family (Hsp40) member B13",TRUE
+"1552976_at",0.929809559076993,0.690295378372093,0.40371063190368,-5.86061109614187,0.110562424750233,"DNAJB13","DnaJ heat shock protein family (Hsp40) member B13",TRUE
+"226399_at",0.686998148149102,0.155589979568897,-1.4701118604872,-4.93851816066555,-0.45348891329099,"DNAJB14","DnaJ heat shock protein family (Hsp40) member B14",TRUE
+"219237_s_at",0.812302873476553,0.359661599884808,-0.935408688738035,-5.5222643014217,-0.315312033789164,"DNAJB14","DnaJ heat shock protein family (Hsp40) member B14",TRUE
+"222850_s_at",0.850693751204364,0.453568214584292,-0.762902160128607,-5.66011077261605,-0.26401261315832,"DNAJB14","DnaJ heat shock protein family (Hsp40) member B14",TRUE
+"202500_at",0.841420204214686,0.432472278766981,-0.799528860188302,-5.63303600612645,-0.302410301897718,"DNAJB2","DnaJ heat shock protein family (Hsp40) member B2",TRUE
+"203811_s_at",0.351608431642378,0.009313853451658,2.84802241077065,-2.61228060600844,1.69860372030157,"DNAJB4","DnaJ heat shock protein family (Hsp40) member B4",TRUE
+"203810_at",0.483137881385504,0.0276230272923838,2.35775708368746,-3.54345582903688,1.61862360782231,"DNAJB4","DnaJ heat shock protein family (Hsp40) member B4",TRUE
+"212817_at",0.411110107932987,0.0162514908006531,-2.60108654342957,-3.09208903776213,-0.824321702837701,"DNAJB5","DnaJ heat shock protein family (Hsp40) member B5",TRUE
+"207453_s_at",0.676475496596199,0.143416876033154,-1.51695631984626,-4.87702032787547,-1.24898181685816,"DNAJB5","DnaJ heat shock protein family (Hsp40) member B5",TRUE
+"209015_s_at",0.817560991958296,0.370045997882279,0.914993741046036,-5.53993268983262,0.536049649303621,"DNAJB6","DnaJ heat shock protein family (Hsp40) member B6",TRUE
+"1552675_at",0.654038356341937,0.123164874465894,1.60268945772644,-4.76051863578141,1.53038741298361,"DNAJB7","DnaJ heat shock protein family (Hsp40) member B7",TRUE
+"237284_at",0.934867348047609,0.71085908526646,-0.375500585187888,-5.87123961956815,-0.167283121127895,"DNAJB8","DnaJ heat shock protein family (Hsp40) member B8",TRUE
+"1562740_at",0.782206338814045,0.304222447813958,1.05181211806342,-5.41474467782155,0.602235488229296,"DNAJB8-AS1","DNAJB8 antisense RNA 1",TRUE
+"1554462_a_at",0.690015152288705,0.159557931389003,-1.45548678748047,-4.95739889305997,-0.545509508023516,"DNAJB9","DnaJ heat shock protein family (Hsp40) member B9",TRUE
+"202842_s_at",0.821424121108148,0.38360564224424,-0.888900768837584,-5.56199113499735,-0.272271850173677,"DNAJB9","DnaJ heat shock protein family (Hsp40) member B9",TRUE
+"202843_at",0.867834927246481,0.500956725054125,-0.684178151215707,-5.7142255418854,-0.287205120758072,"DNAJB9","DnaJ heat shock protein family (Hsp40) member B9",TRUE
+"222620_s_at",0.559624975779079,0.0540706334817573,-2.03423320048035,-4.10309737049826,-1.03392759211631,"DNAJC1","DnaJ heat shock protein family (Hsp40) member C1",TRUE
+"222621_at",0.632949074657601,0.103675656636518,-1.69713584809231,-4.62646156492981,-0.997598944922709,"DNAJC1","DnaJ heat shock protein family (Hsp40) member C1",TRUE
+"218409_s_at",0.750807729565285,0.243780780661303,-1.19746223721233,-5.26441315273176,-0.614230424589806,"DNAJC1","DnaJ heat shock protein family (Hsp40) member C1",TRUE
+"221781_s_at",0.590846912724804,0.0684161281108502,1.91555520362092,-4.29491929052253,0.59372235450274,"DNAJC10","DnaJ heat shock protein family (Hsp40) member C10",TRUE
+"221782_at",0.751464513744428,0.244497405490463,1.19558681573046,-5.26645743398178,0.385638023368832,"DNAJC10","DnaJ heat shock protein family (Hsp40) member C10",TRUE
+"243635_at",0.861388867330702,0.481897648937399,0.715293812292247,-5.69350603487858,0.226778473090649,"DNAJC10","DnaJ heat shock protein family (Hsp40) member C10",TRUE
+"229588_at",0.9181984176728,0.652655523685699,0.45624354765857,-5.83880273754131,0.229726797773785,"DNAJC10","DnaJ heat shock protein family (Hsp40) member C10",TRUE
+"225174_at",0.976371465776674,0.885967771261903,0.145069255962894,-5.92943838921593,0.0455807683267562,"DNAJC10","DnaJ heat shock protein family (Hsp40) member C10",TRUE
+"215792_s_at",0.952914447461733,0.784374463847854,0.276964982111248,-5.90238997320241,0.0784378404305883,"DNAJC11","DnaJ heat shock protein family (Hsp40) member C11",TRUE
+"1555360_a_at",0.998709719538178,0.994378435547435,0.00712556893288496,-5.93965875076621,0.00209910620789522,"DNAJC11","DnaJ heat shock protein family (Hsp40) member C11",TRUE
+"223721_s_at",0.816199380744005,0.367214093914286,-0.920522744522039,-5.53518298473997,-1.23085989407885,"DNAJC12","DnaJ heat shock protein family (Hsp40) member C12",TRUE
+"223722_at",0.831182446031643,0.405314132119335,0.848352061784698,-5.59509439856105,0.91235028145146,"DNAJC12","DnaJ heat shock protein family (Hsp40) member C12",TRUE
+"218976_at",0.859947009633611,0.478362289053337,-0.721143311434934,-5.68951294583191,-0.931200063263753,"DNAJC12","DnaJ heat shock protein family (Hsp40) member C12",TRUE
+"1564627_at",0.870433264908839,0.508844381131161,-0.6714982483376,-5.72241643305732,-0.510163533205752,"DNAJC13","DnaJ heat shock protein family (Hsp40) member C13",TRUE
+"212467_at",0.919138643373719,0.655643826798691,-0.452026851212112,-5.84064976916215,-0.117207787427887,"DNAJC13","DnaJ heat shock protein family (Hsp40) member C13",TRUE
+"1560020_at",0.941467384750897,0.738227521153003,0.338426865723649,-5.88405224959035,0.227405897893478,"DNAJC13","DnaJ heat shock protein family (Hsp40) member C13",TRUE
+"1554451_s_at",0.83030603167465,0.402115473635826,-0.85423729441859,-5.59037901370263,-0.370891031644243,"DNAJC14","DnaJ heat shock protein family (Hsp40) member C14",TRUE
+"223420_at",0.8877101263145,0.552799930953569,-0.602742387623147,-5.76426667958046,-0.224186308718012,"DNAJC14","DnaJ heat shock protein family (Hsp40) member C14",TRUE
+"230305_at",0.776976656039023,0.295812456737234,1.07073906061851,-5.39618839140692,0.376186685303256,"DNAJC15","DnaJ heat shock protein family (Hsp40) member C15",TRUE
+"218435_at",0.837368340567858,0.420681349305561,0.820481999191812,-5.61701079858034,1.06836794567089,"DNAJC15","DnaJ heat shock protein family (Hsp40) member C15",TRUE
+"227808_at",0.84772210282622,0.446841026605554,0.774466849231337,-5.65169138406006,0.420184820981456,"DNAJC15","DnaJ heat shock protein family (Hsp40) member C15",TRUE
+"212911_at",0.808257777979515,0.350747665834446,-0.953250708794249,-5.50652959051413,-0.282849389926032,"DNAJC16","DnaJ heat shock protein family (Hsp40) member C16",TRUE
+"217358_at",0.811071510332727,0.35507650061864,-0.944548436376972,-5.51423810513493,-0.460381903640808,"DNAJC16","DnaJ heat shock protein family (Hsp40) member C16",TRUE
+"212908_at",0.957390359236635,0.807041887408372,-0.247183971013444,-5.90996770420891,-0.0671964036646209,"DNAJC16","DnaJ heat shock protein family (Hsp40) member C16",TRUE
+"219861_at",0.874834820370747,0.521486128360031,-0.651402912057019,-5.73509679059645,-0.299592589939497,"DNAJC17","DnaJ heat shock protein family (Hsp40) member C17",TRUE
+"227166_at",0.697713925841949,0.168691096367426,1.42290755344125,-4.99890483226546,0.663592919927652,"DNAJC18","DnaJ heat shock protein family (Hsp40) member C18",TRUE
+"227169_at",0.763682964138466,0.263707463902919,1.1467768619277,-5.31867633840166,0.659874131336413,"DNAJC18","DnaJ heat shock protein family (Hsp40) member C18",TRUE
+"238115_at",0.838596846474979,0.423677378878433,0.815123514679195,-5.62114603901683,0.346312806305317,"DNAJC18","DnaJ heat shock protein family (Hsp40) member C18",TRUE
+"225359_at",0.841967750949524,0.434687335902892,0.795632319370771,-5.63597317881874,0.232764953932572,"DNAJC19","DnaJ heat shock protein family (Hsp40) member C19",TRUE
+"225358_at",0.895370220688938,0.573858530214708,-0.570831339449322,-5.78220890090701,-0.220779999043728,"DNAJC19","DnaJ heat shock protein family (Hsp40) member C19",TRUE
+"1568884_at",0.907851211906426,0.617400063443088,-0.506657655589184,-5.81542094918083,-0.374760887585831,"DNAJC2","DnaJ heat shock protein family (Hsp40) member C2",TRUE
+"213097_s_at",0.956398858120188,0.802462750087369,0.253180883646477,-5.90851059827385,0.0972373555798143,"DNAJC2","DnaJ heat shock protein family (Hsp40) member C2",TRUE
+"238335_at",0.465776708318531,0.0241067362189149,2.42109358064499,-3.42825825978749,1.0834095810378,"DNAJC21","DnaJ heat shock protein family (Hsp40) member C21",TRUE
+"238337_s_at",0.56861088242915,0.0585352199783411,1.99457668074346,-4.16806007277411,0.654040470950942,"DNAJC21","DnaJ heat shock protein family (Hsp40) member C21",TRUE
+"235001_at",0.67622507827427,0.142786353969939,1.51946998986681,-4.87367670929398,0.367068916938166,"DNAJC21","DnaJ heat shock protein family (Hsp40) member C21",TRUE
+"235032_at",0.688098695247104,0.15751702368016,1.46297191062103,-4.9477548416031,0.537138258577331,"DNAJC21","DnaJ heat shock protein family (Hsp40) member C21",TRUE
+"238336_s_at",0.713633547141264,0.188782746298057,1.35592421015557,-5.08180418283101,0.728473750627176,"DNAJC21","DnaJ heat shock protein family (Hsp40) member C21",TRUE
+"230893_at",0.774360462422895,0.290609639966327,1.08264151960736,-5.38436742696683,0.644856639818611,"DNAJC21","DnaJ heat shock protein family (Hsp40) member C21",TRUE
+"234094_x_at",0.981944022360435,0.913569793746635,-0.10978294912033,-5.93381495618588,-0.0493390122178301,"DNAJC21","DnaJ heat shock protein family (Hsp40) member C21",TRUE
+"239065_at",0.54344488073991,0.0463381807774935,-2.11041278276198,-3.97596115917177,-2.87812041525614,"DNAJC22","DnaJ heat shock protein family (Hsp40) member C22",TRUE
+"244193_at",0.597346378847428,0.0733042663375099,-1.88011867020188,-4.35065527781308,-0.997821803802408,"DNAJC22","DnaJ heat shock protein family (Hsp40) member C22",TRUE
+"220441_at",0.67090497764287,0.136854226714201,-1.54357692936468,-4.84138691362421,-1.25884466338122,"DNAJC22","DnaJ heat shock protein family (Hsp40) member C22",TRUE
+"1570048_at",0.365381351431931,0.0107258723191266,2.78609525837017,-2.7344291288692,1.64466660878474,"DNAJC24","DnaJ heat shock protein family (Hsp40) member C24",TRUE
+"213853_at",0.971735822349954,0.864790659313428,0.172268018832591,-5.92523959180802,0.0803954347852187,"DNAJC24","DnaJ heat shock protein family (Hsp40) member C24",TRUE
+"226859_at",0.953564723226096,0.786244009244308,0.274499399664083,-5.90304980511128,0.108206626239797,"DNAJC25-GNG10///DNAJC25","DNAJC25-GNG10 readthrough///DnaJ heat shock protein family (Hsp40) member C25",TRUE
+"227859_at",0.0681210092794308,0.000173362344922778,-4.5042911291722,0.888352547440681,-2.00813608364263,"DNAJC27","DnaJ heat shock protein family (Hsp40) member C27",TRUE
+"223504_at",0.208428274543958,0.00239667029738782,-3.42635321501336,-1.42633592110701,-1.14567887192748,"DNAJC27","DnaJ heat shock protein family (Hsp40) member C27",TRUE
+"233368_s_at",0.735708712495554,0.220845136178681,-1.25981436133726,-5.1948717886742,-0.870249321807695,"DNAJC27","DnaJ heat shock protein family (Hsp40) member C27",TRUE
+"223505_s_at",0.959649219607517,0.817923450713351,-0.232969949949783,-5.91328265144902,-0.0970531883781467,"DNAJC27","DnaJ heat shock protein family (Hsp40) member C27",TRUE
+"239325_at",0.721046612088315,0.197209245314211,-1.32950262195758,-5.11358655203055,-0.835935100168489,"DNAJC27-AS1","DNAJC27 antisense RNA 1",TRUE
+"220372_at",0.942671206410999,0.742809393430362,0.332268582366596,-5.88605313236347,0.178931861251572,"DNAJC28","DnaJ heat shock protein family (Hsp40) member C28",TRUE
+"1558080_s_at",0.930899509890345,0.694053564842984,0.398530740076904,-5.86261951504147,0.285720877663248,"DNAJC3","DnaJ heat shock protein family (Hsp40) member C3",TRUE
+"208499_s_at",0.943294768503521,0.744947610091044,0.329399197045601,-5.88697300623028,0.155572045561151,"DNAJC3","DnaJ heat shock protein family (Hsp40) member C3",TRUE
+"225284_at",0.945820394457833,0.755364080802587,-0.315460541971416,-5.89132911781282,-0.124862518735862,"DNAJC3","DnaJ heat shock protein family (Hsp40) member C3",TRUE
+"235341_at",0.949038895598021,0.77010419984906,0.295843947615095,-5.8971436225911,0.129460687227002,"DNAJC3","DnaJ heat shock protein family (Hsp40) member C3",TRUE
+"239119_at",0.615821255316333,0.0864962351326833,1.7938559286843,-4.48323579106456,0.775154593519374,"DNAJC3-AS1","DNAJC3 antisense RNA 1 (head to head)",TRUE
+"240574_at",0.678798667679205,0.146399522437552,-1.50518683114102,-4.89261695397445,-0.773287568840218,"DNAJC3-AS1","DNAJC3 antisense RNA 1 (head to head)",TRUE
+"239018_at",0.713642508588139,0.188816690063759,-1.35581593508555,-5.081935494562,-0.859093945096876,"DNAJC30","DnaJ heat shock protein family (Hsp40) member C30",TRUE
+"223367_at",0.864079461576774,0.491213370027422,-0.699998487355623,-5.703800800145,-0.178646851866025,"DNAJC30","DnaJ heat shock protein family (Hsp40) member C30",TRUE
+"239194_at",0.931121627074226,0.695050150265759,0.397159015943146,-5.86314710150783,0.173384098732029,"DNAJC30","DnaJ heat shock protein family (Hsp40) member C30",TRUE
+"206781_at",0.424010380516768,0.0179065380633419,2.55725338460122,-3.17509387017679,1.51668650857836,"DNAJC4","DnaJ heat shock protein family (Hsp40) member C4",TRUE
+"228622_s_at",0.69227042558579,0.161650050726178,-1.4478937397844,-4.96714090712727,-0.752673537172171,"DNAJC4","DnaJ heat shock protein family (Hsp40) member C4",TRUE
+"223371_s_at",0.899808883319249,0.592388234504066,-0.543240361216516,-5.79695947310248,-0.221424150015932,"DNAJC4","DnaJ heat shock protein family (Hsp40) member C4",TRUE
+"206782_s_at",0.935318317015903,0.712366871144817,-0.373444586774113,-5.87198457683576,-0.188494509312001,"DNAJC4","DnaJ heat shock protein family (Hsp40) member C4",TRUE
+"213919_at",0.975159323713639,0.87904348291816,-0.15394910353205,-5.92814651412476,-0.0492243342164294,"DNAJC4","DnaJ heat shock protein family (Hsp40) member C4",TRUE
+"224613_s_at",0.657015752622694,0.125422510090483,-1.59257663749089,-4.77452180099154,-0.49049569418845,"DNAJC5","DnaJ heat shock protein family (Hsp40) member C5",TRUE
+"224612_s_at",0.675447258877226,0.141733637772661,-1.52368716384687,-4.86805722510267,-0.465742952769727,"DNAJC5","DnaJ heat shock protein family (Hsp40) member C5",TRUE
+"224611_s_at",0.68713870484566,0.155762345417336,-1.4694703126058,-4.93934959538778,-0.551009569137445,"DNAJC5","DnaJ heat shock protein family (Hsp40) member C5",TRUE
+"1554258_a_at",0.823531358962779,0.390640801000451,0.87560083874336,-5.57300717925729,0.32880111754112,"DNAJC5B","DnaJ heat shock protein family (Hsp40) member C5 beta",TRUE
+"232798_at",0.908801761853008,0.621271246018908,0.50105890740575,-5.81813569155259,0.17044877535314,"DNAJC5B","DnaJ heat shock protein family (Hsp40) member C5 beta",TRUE
+"1552450_a_at",0.911393258378799,0.629493932781655,0.489220104312767,-5.8237791394576,0.176788527359474,"DNAJC5G","DnaJ heat shock protein family (Hsp40) member C5 gamma",TRUE
+"204721_s_at",0.951023815565189,0.776431587481338,-0.287459942118344,-5.89951583721412,-0.198083403894048,"DNAJC6","DnaJ heat shock protein family (Hsp40) member C6",TRUE
+"204720_s_at",0.972112264314695,0.866064321936228,-0.170628639093122,-5.92551300101596,-0.149287701141205,"DNAJC6","DnaJ heat shock protein family (Hsp40) member C6",TRUE
+"1556053_at",0.61760967235709,0.0876578389129184,1.78681847463428,-4.4938537152264,0.656270727792103,"DNAJC7","DnaJ heat shock protein family (Hsp40) member C7",TRUE
+"215252_at",0.841420204214686,0.432059925006583,0.800255599726625,-5.63248670467061,0.421715679559641,"DNAJC7","DnaJ heat shock protein family (Hsp40) member C7",TRUE
+"202416_at",0.881466832418197,0.538290423479879,-0.625100424907416,-5.75113464209263,-0.237346641394989,"DNAJC7","DnaJ heat shock protein family (Hsp40) member C7",TRUE
+"212490_at",0.827985973549523,0.397536936160464,-0.862713862898148,-5.58353403426099,-0.285269930123195,"DNAJC8","DnaJ heat shock protein family (Hsp40) member C8",TRUE
+"212491_s_at",0.909441542080538,0.623659317832193,-0.497613216012099,-5.81979181480976,-0.15565544356979,"DNAJC8","DnaJ heat shock protein family (Hsp40) member C8",TRUE
+"205545_x_at",0.955730092376044,0.797344149012363,-0.25989554775502,-5.90683790740556,-0.0826491924796873,"DNAJC8","DnaJ heat shock protein family (Hsp40) member C8",TRUE
+"213088_s_at",0.819723837900625,0.377153521300975,0.901239504218067,-5.55163373847249,0.279227180209267,"DNAJC9","DnaJ heat shock protein family (Hsp40) member C9",TRUE
+"213092_x_at",0.820372117334399,0.379434295439457,0.896862125252593,-5.55532332199184,0.344124374710772,"DNAJC9","DnaJ heat shock protein family (Hsp40) member C9",TRUE
+"229701_at",0.975398143273847,0.880857495068796,0.151621581850247,-5.92849253496429,0.0793119794480477,"DNAJC9","DnaJ heat shock protein family (Hsp40) member C9",TRUE
+"1557827_at",0.553325561986119,0.0504798884899271,2.06830559237899,-4.04660933152236,0.675538036359443,"DNAJC9-AS1","DNAJC9 antisense RNA 1",TRUE
+"226309_at",0.891893744815216,0.561905293715683,-0.588869007985971,-5.77218304544417,-0.197611244291063,"DNAL1","dynein axonemal light chain 1",TRUE
+"223959_at",0.917906507115144,0.651389454756779,-0.458032587835874,-5.83801400891392,-0.144453925030542,"DNAL1","dynein axonemal light chain 1",TRUE
+"223958_s_at",0.933609099853387,0.706162994197864,0.381914740968674,-5.86888963185477,0.140633899747419,"DNAL1","dynein axonemal light chain 1",TRUE
+"204008_at",0.991249206045988,0.958966979428081,0.052035146841301,-5.93836476714338,0.0458169223918201,"DNAL4","dynein axonemal light chain 4",TRUE
+"205186_at",0.729273475042162,0.211484288753431,-1.28668932924206,-5.16396505849683,-2.20777885342755,"DNALI1","dynein axonemal light intermediate chain 1",TRUE
+"227081_at",0.734551465704364,0.218816676561633,-1.26556266477389,-5.18830799655546,-2.21752306870839,"DNALI1","dynein axonemal light intermediate chain 1",TRUE
+"228929_at",0.567651250567208,0.0577721662016246,-2.00115956130234,-4.15733552953991,-1.53230233609789,"DNASE1","deoxyribonuclease 1",TRUE
+"241854_at",0.662855903464759,0.130784731658863,-1.56915092554928,-4.80669324728022,-1.41055043417233,"DNASE1","deoxyribonuclease 1",TRUE
+"1557189_at",0.813442508625161,0.363999714970703,0.926833017268677,-5.52972993007352,0.28201044234808,"DNASE1","deoxyribonuclease 1",TRUE
+"210165_at",0.886148073306164,0.5488643285641,-0.60877583016864,-5.76076836962853,-0.54011912198338,"DNASE1","deoxyribonuclease 1",TRUE
+"243127_x_at",0.931582451098271,0.697639861592575,-0.393598090226448,-5.86450832595993,-0.423585543881418,"DNASE1","deoxyribonuclease 1",TRUE
+"240144_at",0.959741600760902,0.818242249252285,0.232554273475366,-5.91337665628497,0.18271625256755,"DNASE1","deoxyribonuclease 1",TRUE
+"1558546_at",0.975552150564853,0.883602632702364,-0.148100977964006,-5.9290059302768,-0.0416289884155177,"DNASE1","deoxyribonuclease 1",TRUE
+"203912_s_at",0.812302873476553,0.359528217775506,-0.935673457228084,-5.52203279921415,-0.45512919223165,"DNASE1L1","deoxyribonuclease 1 like 1",TRUE
+"207192_at",0.686747966354964,0.155168890759964,-1.471681586282,-4.93648258582267,-1.13215802693213,"DNASE1L2","deoxyribonuclease 1 like 2",TRUE
+"205554_s_at",0.470885186348082,0.0255366141854449,2.39436994517815,-3.47707043284644,0.876183552038087,"DNASE1L3","deoxyribonuclease 1 like 3",TRUE
+"1561336_at",0.996261754016157,0.98129940882017,-0.0237058950375283,-5.93940976985176,-0.0156274006928241,"DNASE1L3","deoxyribonuclease 1 like 3",TRUE
+"214992_s_at",0.861659105448003,0.482702514713171,0.713965599529895,-5.6944084116604,0.386626856865828,"DNASE2","deoxyribonuclease 2, lysosomal",TRUE
+"209831_x_at",0.895213601869362,0.573359672889713,0.571580271758875,-5.78179863307722,0.193152851217551,"DNASE2","deoxyribonuclease 2, lysosomal",TRUE
+"220380_at",0.998038817582822,0.99088655529891,0.0115518400820199,-5.93961848481415,0.0109224622815454,"DNASE2B","deoxyribonuclease 2 beta",TRUE
+"57739_at",0.896907177224677,0.58200059630606,-0.558653779130031,-5.78880662201851,-0.19402506432602,"DND1","DND microRNA-mediated repression inhibitor 1",TRUE
+"222070_at",0.991754150288374,0.961758873993373,0.0484916578262865,-5.93853824549136,0.0139733808560436,"DND1","DND microRNA-mediated repression inhibitor 1",TRUE
+"226281_at",0.539609110035715,0.0445081451334396,2.13010551704701,-3.94260810211862,2.28850010678954,"DNER","delta/notch like EGF repeat containing",TRUE
+"242540_at",0.68747436517451,0.156314124886766,1.46742044595255,-4.94200421756476,1.00316361319978,"DNHD1","dynein heavy chain domain 1",TRUE
+"229631_at",0.753294178355034,0.246529085759894,1.1902921842775,-5.272213732389,0.903158329188482,"DNHD1","dynein heavy chain domain 1",TRUE
+"232240_at",0.893452464710995,0.568198182907472,0.579348716090356,-5.77751232129366,0.298619955305423,"DNHD1","dynein heavy chain domain 1",TRUE
+"1560781_at",0.975398143273847,0.881935289003511,0.150239093480943,-5.92869557265145,0.137910803129911,"DNHD1","dynein heavy chain domain 1",TRUE
+"228272_at",0.547024587451534,0.0474964080594486,-2.09830779160084,-3.99636491692323,-0.762694543791229,"DNLZ","DNL-type zinc finger",TRUE
+"220162_s_at",0.937113154905832,0.720930105562855,-0.361798598845832,-5.8761281120204,-0.323274392330955,"DNLZ///CARD9","DNL-type zinc finger///caspase recruitment domain family member 9",TRUE
+"215116_s_at",0.346761268605178,0.00890810451177229,2.86747629020849,-2.57367676788464,3.01259237769022,"DNM1","dynamin 1",TRUE
+"217341_at",0.737488397392592,0.223710028956382,1.25176425975181,-5.20402087573521,0.79473937513152,"DNM1","dynamin 1",TRUE
+"203105_s_at",0.792778640449105,0.324543213983316,1.00755985019626,-5.45696647448637,0.393771213089849,"DNM1L","dynamin 1 like",TRUE
+"226154_at",0.918583761142768,0.654122362255739,0.454172695031684,-5.8397119300453,0.182107150449289,"DNM1L","dynamin 1 like",TRUE
+"237797_at",0.957289701021675,0.806750379214491,0.247565456509628,-5.90987604643788,0.212510204135297,"DNM1L","dynamin 1 like",TRUE
+"1561249_a_at",0.725225714005638,0.204004227322638,-1.30883294445309,-5.13808279573132,-0.798449248680586,"DNM1P35","dynamin 1 pseudogene 35",TRUE
+"232143_at",0.9116561917482,0.630665646717584,-0.487538897298252,-5.82456986583033,-0.309020558970169,"DNM1P41","dynamin 1 pseudogene 41",TRUE
+"231318_at",0.900881365977893,0.59694615469617,-0.53651922068429,-5.80044518316245,-0.236176955733067,"DNM1P46","dynamin 1 pseudogene 46",TRUE
+"1555895_at",0.780323446630392,0.301798824369142,1.05722792885703,-5.40946523682333,1.03564718447863,"DNM2","dynamin 2",TRUE
+"202253_s_at",0.846529455216068,0.44479678611178,0.778002011159094,-5.64909383869675,0.331562396199603,"DNM2","dynamin 2",TRUE
+"216024_at",0.973071267819624,0.870679353745615,-0.164692428184967,-5.92648120567514,-0.0909682088612951,"DNM2","dynamin 2",TRUE
+"1558501_at",0.703077519740086,0.174921640444201,1.40148585437806,-5.02577589678887,2.07922507826306,"DNM3","dynamin 3",TRUE
+"1558502_s_at",0.969642324744141,0.855237718538529,0.184579720046393,-5.92310300993146,0.156579009216525,"DNM3","dynamin 3",TRUE
+"209839_at",0.990810941805126,0.953836001950478,-0.0585492285384238,-5.93801396033576,-0.0508896093983502,"DNM3","dynamin 3",TRUE
+"232090_at",0.713330901550199,0.188014120213787,1.35838011956413,-5.07882340037202,1.52407880774782,"DNM3OS","DNM3 opposite strand/antisense RNA",TRUE
+"235891_at",0.908801761853008,0.621187335381088,-0.501180091680362,-5.81807724296512,-0.313786378715679,"DNM3OS","DNM3 opposite strand/antisense RNA",TRUE
+"1562969_at",0.61300755398212,0.0846157843603669,1.80542326158269,-4.46571748339803,1.92158983418463,"DNMBP","dynamin binding protein",TRUE
+"212838_at",0.740061288163266,0.22847454240588,1.23854907499689,-5.21893090398606,0.870469429129823,"DNMBP","dynamin binding protein",TRUE
+"201697_s_at",0.635368778245437,0.106362887691938,1.68326580275899,-4.6465143261281,0.633202780740858,"DNMT1","DNA (cytosine-5-)-methyltransferase 1",TRUE
+"222640_at",0.784708646973769,0.308774061838019,-1.04172325973493,-5.42451451628654,-0.548143249874352,"DNMT3A","DNA methyltransferase 3 alpha",TRUE
+"244428_at",0.864157648955443,0.49134099374628,-0.699790110436051,-5.7039395870605,-0.470828301260656,"DNMT3A","DNA methyltransferase 3 alpha",TRUE
+"218457_s_at",0.938984663220785,0.72728161898626,-0.353193452091317,-5.87910646617891,-0.360796504624076,"DNMT3A","DNA methyltransferase 3 alpha",TRUE
+"220668_s_at",0.974982245454858,0.878427537096973,-0.154739608347743,-5.92802779734368,-0.0735556417658021,"DNMT3B","DNA methyltransferase 3 beta",TRUE
+"220139_at",0.988139605576153,0.943410397836686,-0.0717934631249675,-5.93717332239184,-0.0368672916565758,"DNMT3L","DNA methyltransferase 3 like",TRUE
+"201937_s_at",0.789795896476304,0.318262474856838,-1.02102439636947,-5.44429315915104,-0.394571388284964,"DNPEP","aspartyl aminopeptidase",TRUE
+"38703_at",0.813442508625161,0.36359413436822,-0.927631868197467,-5.52903715407848,-0.341440091474702,"DNPEP","aspartyl aminopeptidase",TRUE
+"215135_at",0.927909601142037,0.683624692179933,0.412932669257461,-5.85697222759777,0.133731441264705,"DNPEP","aspartyl aminopeptidase",TRUE
+"204238_s_at",0.830174822125931,0.401945823343716,-0.854550270957817,-5.59012739884639,-0.388296937967061,"DNPH1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1",TRUE
+"213871_s_at",0.911274533678096,0.629325562839186,-0.489461803497388,-5.82366524177503,-0.260768434303158,"DNPH1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1",TRUE
+"39817_s_at",0.932091525948902,0.700522719496796,-0.389640160852595,-5.86600713797674,-0.13188778856016,"DNPH1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1",TRUE
+"1566363_at",0.757950630724418,0.254316915187489,1.17029406031889,-5.2937544172998,0.550382034830756,"DNTT","DNA nucleotidylexotransferase",TRUE
+"210487_at",0.8288884913487,0.399722504792956,0.858659781602049,-5.58681562823213,0.315638065319883,"DNTT","DNA nucleotidylexotransferase",TRUE
+"1566362_at",0.843850838418098,0.439944547766034,0.786433018969951,-5.64285394225412,0.647468715501721,"DNTT","DNA nucleotidylexotransferase",TRUE
+"234942_s_at",0.948962238903406,0.76969077304517,-0.29639249987503,-5.89698605521449,-0.0994310536276313,"DNTTIP1","deoxynucleotidyltransferase terminal interacting protein 1",TRUE
+"224825_at",0.985425981490741,0.9290142201192,0.0901039081423333,-5.93572992786782,0.027457304232879,"DNTTIP1","deoxynucleotidyltransferase terminal interacting protein 1",TRUE
+"202776_at",0.976003735458276,0.884953630281225,0.146369047156686,-5.92925407400295,0.0515920403083285,"DNTTIP2","deoxynucleotidyltransferase terminal interacting protein 2",TRUE
+"205744_at",0.7768734672127,0.294930147972359,-1.07274688889675,-5.39420250043005,-0.555890706262328,"DOC2A","double C2 domain alpha",TRUE
+"207311_at",0.647754107214051,0.119200109336419,-1.62082988626294,-4.73522753337538,-1.07304107777594,"DOC2B","double C2 domain beta",TRUE
+"232930_at",0.595019326272843,0.0719010857661339,1.89007389774471,-4.33507082965374,1.98287658705037,"DOCK1","dedicator of cytokinesis 1",TRUE
+"241708_at",0.790240875783718,0.319688719975444,1.01795066033182,-5.44719967612759,0.999783101709313,"DOCK1","dedicator of cytokinesis 1",TRUE
+"232973_at",0.827866702343255,0.39733247125506,0.863093864849844,-5.58322570268011,0.330857101020267,"DOCK1","dedicator of cytokinesis 1",TRUE
+"241709_s_at",0.843475287501313,0.43834048313212,0.789232680680405,-5.64076786466457,0.34333673794908,"DOCK1","dedicator of cytokinesis 1",TRUE
+"203187_at",0.984132887597385,0.922175233425579,0.0988130667650081,-5.93492890427333,0.0530290610312587,"DOCK1","dedicator of cytokinesis 1",TRUE
+"219279_at",0.864894115958506,0.493160133694649,0.696823288363964,-5.70591132704285,0.937344217989099,"DOCK10","dedicator of cytokinesis 10",TRUE
+"215151_at",0.894692956611947,0.571488537016532,-0.574392348973751,-5.78025351499849,-0.480375072448806,"DOCK10","dedicator of cytokinesis 10",TRUE
+"226875_at",0.93789466363241,0.725409383915696,-0.355727137176186,-5.87823688042198,-0.379918631483474,"DOCK11","dedicator of cytokinesis 11",TRUE
+"238356_at",0.986342822130003,0.934776745386305,0.0827711442259801,-5.93634713172293,0.0348713871917443,"DOCK11","dedicator of cytokinesis 11",TRUE
+"213160_at",0.725583196024696,0.204659343018666,1.30686863518157,-5.14039387958402,1.21829104388999,"DOCK2","dedicator of cytokinesis 2",TRUE
+"1554325_at",0.76772687203753,0.269613601645955,1.13230079198717,-5.3337956994389,0.466062580989926,"DOCK2","dedicator of cytokinesis 2",TRUE
+"213482_at",0.697699759202153,0.168316289183906,1.42421628396949,-4.99725232834614,1.38385462267907,"DOCK3","dedicator of cytokinesis 3",TRUE
+"1558691_a_at",0.922635094827638,0.669318442682686,0.432835396655103,-5.84884358862979,0.296046243173506,"DOCK4","dedicator of cytokinesis 4",TRUE
+"205003_at",0.935810894498532,0.71376383542229,-0.37154116562681,-5.87267065278219,-0.316537989558444,"DOCK4","dedicator of cytokinesis 4",TRUE
+"241313_at",0.959357995170594,0.816213994030247,0.235199602035797,-5.91277556756102,0.0853422276684856,"DOCK4","dedicator of cytokinesis 4",TRUE
+"244840_x_at",0.978193911160351,0.894070129353749,0.134693718078858,-5.930850849143,0.102327833164141,"DOCK4","dedicator of cytokinesis 4",TRUE
+"1562011_at",0.623503825356688,0.0942086041178221,1.74857106463856,-4.55102540707275,0.941847607421835,"DOCK4-AS1","DOCK4 antisense RNA 1",TRUE
+"219921_s_at",0.30050033261608,0.00566310803610979,3.0632001811991,-2.17964255586757,1.10129169082887,"DOCK5","dedicator of cytokinesis 5",TRUE
+"230263_s_at",0.366473876333673,0.0108162278423511,2.78240130695675,-2.74167881969302,1.30620820937012,"DOCK5","dedicator of cytokinesis 5",TRUE
+"1570078_a_at",0.668518995965071,0.134697608578303,1.55255453955862,-4.8292591025485,0.961649232454758,"DOCK5","dedicator of cytokinesis 5",TRUE
+"230206_at",0.677013732819214,0.144260505390605,1.51360719550357,-4.88146838159315,1.14433888228638,"DOCK5","dedicator of cytokinesis 5",TRUE
+"230207_s_at",0.714589649842283,0.189851472402542,1.35252248379667,-5.08592547391911,0.980948056567545,"DOCK5","dedicator of cytokinesis 5",TRUE
+"1569590_at",0.888232641270866,0.553901966556896,0.601056965956126,-5.76523790956335,0.165115780655893,"DOCK5","dedicator of cytokinesis 5",TRUE
+"215361_at",0.962555471240652,0.829813482156893,-0.217494418752338,-5.91666976111665,-0.157340966681771,"DOCK5","dedicator of cytokinesis 5",TRUE
+"1561276_at",0.99691938672319,0.984414186675856,-0.0197568411576356,-5.93949336583532,-0.0170183641349646,"DOCK5","dedicator of cytokinesis 5",TRUE
+"221793_at",0.731314021977412,0.214451901497281,1.27807186719821,-5.17393593146055,0.771708418162849,"DOCK6","dedicator of cytokinesis 6",TRUE
+"222003_s_at",0.792436690618566,0.323731552538179,1.00928959356603,-5.45534690500873,0.469515977810554,"DOCK6","dedicator of cytokinesis 6",TRUE
+"222004_s_at",0.851733415458562,0.456649256215542,-0.757640134651868,-5.66390202940951,-0.44080049004359,"DOCK6","dedicator of cytokinesis 6",TRUE
+"221794_at",0.895999830738594,0.576851309084174,0.566345189686966,-5.78465551485689,0.322761342225256,"DOCK6","dedicator of cytokinesis 6",TRUE
+"55583_at",0.925511384407886,0.678052140744206,0.420664553510197,-5.85385905316072,0.193743181573049,"DOCK6","dedicator of cytokinesis 6",TRUE
+"237470_at",0.815979818937459,0.366970786792011,0.920999098671798,-5.53477253791328,0.904732153889042,"DOCK7","dedicator of cytokinesis 7",TRUE
+"225384_at",0.916190220640741,0.646385396817484,-0.465118605623493,-5.8348603089133,-0.175939568492719,"DOCK7","dedicator of cytokinesis 7",TRUE
+"239027_at",0.643082025527735,0.113481371663892,-1.64790711923066,-4.69706915052258,-1.31454555464054,"DOCK8","dedicator of cytokinesis 8",TRUE
+"232842_at",0.686998148149102,0.155536814301313,1.47030985860456,-4.93826149930714,0.417301734868971,"DOCK8","dedicator of cytokinesis 8",TRUE
+"232843_s_at",0.922168942129244,0.667563674658277,-0.435288730914463,-5.84781558286749,-0.450575358257179,"DOCK8","dedicator of cytokinesis 8",TRUE
+"225502_at",0.934081042629428,0.70834892539236,-0.378927073705965,-5.86998912292809,-0.384848023572384,"DOCK8","dedicator of cytokinesis 8",TRUE
+"215041_s_at",0.744688669253745,0.236053100419876,1.21795406206852,-5.2418951175226,0.638191789659897,"DOCK9","dedicator of cytokinesis 9",TRUE
+"232874_at",0.751748627874974,0.245000618200351,1.19427236141257,-5.26788857774398,1.14522373905551,"DOCK9","dedicator of cytokinesis 9",TRUE
+"212538_at",0.822812833182588,0.387938390957161,0.880691119745834,-5.56880920366221,0.471259701079648,"DOCK9","dedicator of cytokinesis 9",TRUE
+"215238_s_at",0.894729774938685,0.571764064893432,0.573977972660227,-5.78048165882447,0.36205858115175,"DOCK9","dedicator of cytokinesis 9",TRUE
+"215237_at",0.995111934465262,0.977201080954962,0.0289025363918327,-5.93927661753436,0.0181479776548947,"DOCK9","dedicator of cytokinesis 9",TRUE
+"239356_at",0.67842163564685,0.145742376777101,1.50776294993398,-4.88921145107956,0.531958915024674,"DOCK9-AS2","DOCK9 antisense RNA 2 (head to head)",TRUE
+"231062_at",0.945357285954224,0.753104379460854,-0.318478822147388,-5.89040166065684,-0.0940211439136514,"DOCK9-AS2","DOCK9 antisense RNA 2 (head to head)",TRUE
+"208141_s_at",0.940778455596726,0.734976657066537,-0.342804295420686,-5.88260788703177,-0.0995429991057328,"DOHH","deoxyhypusine hydroxylase/monooxygenase",TRUE
+"213949_s_at",0.971756447182966,0.864921001293312,-0.172100228579075,-5.92526769495013,-0.106068943000574,"DOHH","deoxyhypusine hydroxylase/monooxygenase",TRUE
+"210030_at",0.973071267819624,0.870338227771946,-0.165131000848741,-5.92641084348266,-0.0913779906066012,"DOHH","deoxyhypusine hydroxylase/monooxygenase",TRUE
+"211121_s_at",0.728385463227073,0.208929419384968,-1.29418340173473,-5.15524767901017,-0.794575920928981,"DOK1","docking protein 1",TRUE
+"216835_s_at",0.986342822130003,0.935144678490088,0.0823031147616183,-5.93638474968164,0.031502508304178,"DOK1","docking protein 1",TRUE
+"214054_at",0.851733415458562,0.456516281819809,0.757866796189517,-5.66373923265629,0.382742102611624,"DOK2","docking protein 2",TRUE
+"223553_s_at",0.774230543658252,0.287487645565265,-1.08985737353981,-5.37714420836775,-0.479196899451188,"DOK3","docking protein 3",TRUE
+"220320_at",0.841550580403629,0.433066836129032,-0.79848175627493,-5.63382662800684,-0.500759264954546,"DOK3","docking protein 3",TRUE
+"209691_s_at",0.711017253641982,0.184740943854376,1.36892812203859,-5.06596994353242,1.10391969073492,"DOK4","docking protein 4",TRUE
+"207747_s_at",0.830326542770255,0.402733051444433,0.853098680529025,-5.59129366816129,0.391344161489702,"DOK4","docking protein 4",TRUE
+"209690_s_at",0.871451481476429,0.51272530266317,0.66529990503741,-5.72636702568593,0.489472703249579,"DOK4","docking protein 4",TRUE
+"214844_s_at",0.8920930097751,0.56392536770868,0.585806960541363,-5.7739062883868,0.324160444487674,"DOK5","docking protein 5",TRUE
+"1554863_s_at",0.98539961718117,0.928711148756835,-0.0904897003888684,-5.93569600672454,-0.0703397439247695,"DOK5","docking protein 5",TRUE
+"231980_at",0.728385463227073,0.2095302146469,-1.29241476990911,-5.15730889492669,-1.14174375162036,"DOK6","docking protein 6",TRUE
+"236290_at",0.83629640285155,0.417589905701878,0.826036300559466,-5.61269765440026,0.26083815557248,"DOK6","docking protein 6",TRUE
+"241729_at",0.941106542715586,0.736132989908765,0.34124646484569,-5.88312400755663,0.295381097486521,"DOK6","docking protein 6",TRUE
+"240633_at",0.951810226174863,0.779304417976928,0.283660313544803,-5.90056864695679,0.375459258894347,"DOK7","docking protein 7",TRUE
+"204488_at",0.382928576778789,0.012138156002878,-2.73146411290261,-2.84121366504513,-0.916068823353882,"DOLK","dolichol kinase",TRUE
+"221817_at",0.630603891142543,0.1019411552084,-1.70625136626539,-4.61321530115617,-0.466805104323212,"DOLPP1","dolichyldiphosphatase 1",TRUE
+"221677_s_at",0.62110896023334,0.0915117488619261,1.76403137823242,-4.52802492219198,0.723138501204849,"DONSON","downstream neighbor of SON",TRUE
+"213271_s_at",0.655235030401569,0.123976340000077,-1.59903693425974,-4.76558421700175,-0.628421503440441,"DOPEY1","dopey family member 1",TRUE
+"213267_at",0.866047073324492,0.4966573721899,-0.691137207282147,-5.70966793198698,-0.499250713530727,"DOPEY1","dopey family member 1",TRUE
+"1564387_at",0.912241810302154,0.632093149215047,0.485492601025471,-5.82552871581983,0.338260925939352,"DOPEY1","dopey family member 1",TRUE
+"40612_at",0.939166148226364,0.727727246265976,-0.352590734875465,-5.8793124204687,-0.118441146005245,"DOPEY1","dopey family member 1",TRUE
+"205248_at",0.647754107214051,0.118989973755794,-1.62180535185199,-4.73386131948862,-0.743044713352264,"DOPEY2","dopey family member 2",TRUE
+"215219_at",0.758781268361953,0.256021890054711,-1.16597694073835,-5.2983626470077,-0.989135132635399,"DOPEY2","dopey family member 2",TRUE
+"226201_at",0.495138127083296,0.0301475048022001,-2.31671967055595,-3.61717326819862,-0.662169150984161,"DOT1L","DOT1 like histone lysine methyltransferase",TRUE
+"214865_at",0.867229632004967,0.499368824954959,-0.68674440649213,-5.71254998413222,-0.342333463004263,"DOT1L","DOT1 like histone lysine methyltransferase",TRUE
+"231297_at",0.943824294237045,0.748240768792039,-0.324985435867712,-5.88837256524728,-0.119817382047973,"DOT1L","DOT1 like histone lysine methyltransferase",TRUE
+"209509_s_at",0.92777930247318,0.683307622725692,0.413371910646453,-5.85679689266012,0.143777258351069,"DPAGT1","dolichyl-phosphate N-acetylglucosaminephosphotransferase 1",TRUE
+"226009_at",0.868362470085218,0.502982402303428,0.680911068224771,-5.71635000748725,0.299488119400159,"DPCD","deleted in primary ciliary dyskinesia homolog (mouse)",TRUE
+"1553976_a_at",0.980025041090473,0.906270289500132,0.119098850543748,-5.93277707682944,0.051959041902137,"DPCD","deleted in primary ciliary dyskinesia homolog (mouse)",TRUE
+"231646_at",0.854343866520736,0.465113467899945,-0.743292974337199,-5.67411285580635,-0.458612039167358,"DPCR1","diffuse panbronchiolitis critical region 1",TRUE
+"241137_at",0.999886947266554,0.999713837596485,-0.00036271965969011,-5.93968341666838,-0.000250006461368635,"DPCR1","diffuse panbronchiolitis critical region 1",TRUE
+"205983_at",0.885312914741353,0.546792890479622,0.611960591215905,-5.75890822581776,0.314157178612098,"DPEP1","dipeptidase 1 (renal)",TRUE
+"219452_at",0.794426378358553,0.326118246407526,-1.00421184270352,-5.46009408127019,-0.301720228768994,"DPEP2","dipeptidase 2",TRUE
+"220179_at",0.547343369043481,0.0477447266385042,2.09574710531964,-4.00067147794344,1.03351814870588,"DPEP3","dipeptidase 3",TRUE
+"231599_x_at",0.828607509614823,0.398876124948098,-0.860228062099706,-5.58554788300257,-0.298504829993745,"DPF1","double PHD fingers 1",TRUE
+"206531_at",0.944707251970536,0.751359759523343,-0.320811173868413,-5.88967898561356,-0.168003249433872,"DPF1","double PHD fingers 1",TRUE
+"202116_at",0.770807031642694,0.279254147584983,-1.10916281576151,-5.35760920796666,-0.4701623293602,"DPF2","double PHD fingers 2",TRUE
+"236442_at",0.768311775820646,0.271505291643909,-1.12771347672183,-5.33855150073569,-0.870338483507263,"DPF3","double PHD fingers 3",TRUE
+"238532_at",0.913233126230689,0.636160454862675,-0.479673672701507,-5.82823379036936,-0.441773873839097,"DPF3","double PHD fingers 3",TRUE
+"235357_at",0.939899468413492,0.729806539208604,0.349780216379473,-5.8802682122527,0.246986410969306,"DPF3","double PHD fingers 3",TRUE
+"219746_at",0.981567323255511,0.912395326977441,0.111281154035027,-5.93365373614991,0.0305033249924005,"DPF3","double PHD fingers 3",TRUE
+"204514_at",0.963916425729083,0.834935857450456,0.210844295575579,-5.91805410131309,0.0766179505392461,"DPH2","DPH2 homolog",TRUE
+"225195_at",0.878110025868144,0.529997820825766,0.638023584125036,-5.74333419382866,0.250928089662025,"DPH3","diphthamide biosynthesis 3",TRUE
+"225200_at",0.97689149311934,0.889734788198514,0.140243415420952,-5.93010835612056,0.0579744446621326,"DPH3","diphthamide biosynthesis 3",TRUE
+"233000_x_at",0.567651250567208,0.0577542213404156,2.00131529887185,-4.15708152193723,1.28927748745686,"DPH3P1","diphthamide biosynthesis 3 pseudogene 1",TRUE
+"222360_at",0.923376218980614,0.671150244889577,0.430277238031744,-5.84990944082896,0.222403629820005,"DPH5","diphthamide biosynthesis 5",TRUE
+"223671_x_at",0.939641108570911,0.729302424934892,0.35046134812359,-5.88003726920246,0.131357228546877,"DPH5","diphthamide biosynthesis 5",TRUE
+"224060_s_at",0.943294768503521,0.745277706107147,-0.328956475692106,-5.88711423178506,-0.133527233584648,"DPH5","diphthamide biosynthesis 5",TRUE
+"219590_x_at",0.989669132517581,0.95045195135532,0.0628468857195268,-5.937759895477,0.0228241484161202,"DPH5","diphthamide biosynthesis 5",TRUE
+"224196_x_at",0.999509719152342,0.998924729467607,-0.00136293892578326,-5.93968257597945,-0.000471992391721798,"DPH5","diphthamide biosynthesis 5",TRUE
+"238662_at",0.917366858764505,0.650202112681154,0.459711761877873,-5.83727096479295,0.178868591977661,"DPH6","diphthamine biosynthesis 6",TRUE
+"1560404_a_at",0.935810894498532,0.713766546362648,0.371537473220536,-5.87267198032451,0.386869572993622,"DPH6","diphthamine biosynthesis 6",TRUE
+"238744_at",0.971084206066165,0.861392097119395,-0.176644816850232,-5.92449687725528,-0.0857209471218825,"DPH6","diphthamine biosynthesis 6",TRUE
+"240523_at",0.966111788889917,0.842260179426642,-0.20135228368212,-5.91995587616304,-0.178371810529555,"DPH6-AS1","DPH6 antisense RNA 1 (head to head)",TRUE
+"225586_at",0.767965891104819,0.270952817658594,-1.12905078961374,-5.33716683120733,-0.448815202372039,"DPH7","diphthamide biosynthesis 7",TRUE
+"202673_at",0.948814396904806,0.767090054588806,-0.29984538128469,-5.89598759781968,-0.0910347787653851,"DPM1","dolichyl-phosphate mannosyltransferase subunit 1, catalytic",TRUE
+"209391_at",0.56861088242915,0.0583870849476792,-1.99584866283871,-4.16598966232916,-0.552903012832971,"DPM2","dolichyl-phosphate mannosyltransferase subunit 2, regulatory",TRUE
+"219373_at",0.327864702134751,0.00768205120417849,-2.93186617299211,-2.44514787153651,-1.32710220891267,"DPM3","dolichyl-phosphate mannosyltransferase subunit 3",TRUE
+"228598_at",0.992610163453252,0.965468833881005,-0.0437839313482898,-5.93874980796277,-0.0465968456837222,"DPP10","dipeptidyl peptidase like 10",TRUE
+"236351_at",0.547195868806649,0.0476386607140782,-2.09683940115463,-3.9988348683502,-1.62979536751714,"DPP10-AS1","DPP10 antisense RNA 1",TRUE
+"1561618_at",0.990810941805126,0.956539160363886,0.0551171025680294,-5.93820394242006,0.0223517733826677,"DPP10-AS3","DPP10 antisense RNA 3",TRUE
+"218567_x_at",0.716747751818469,0.192666515015565,1.34363384969761,-5.09665340898496,0.518439520195118,"DPP3","dipeptidyl peptidase 3",TRUE
+"232510_s_at",0.73148417124022,0.214634385560996,1.27754497177066,-5.17454372561699,0.491548879258492,"DPP3","dipeptidyl peptidase 3",TRUE
+"203716_s_at",0.417001048339868,0.0170146192714361,2.58037952034915,-3.13138853015462,1.76528330808947,"DPP4","dipeptidyl peptidase 4",TRUE
+"211478_s_at",0.562638706929609,0.0551746863996613,2.02416267490746,-4.11967475255115,2.53915170784089,"DPP4","dipeptidyl peptidase 4",TRUE
+"203717_at",0.601115828839805,0.0767783342238019,1.85616909883127,-4.38790927834251,1.54811731499226,"DPP4","dipeptidyl peptidase 4",TRUE
+"207789_s_at",0.686599929500302,0.155076772371271,1.47202544385494,-4.93603644671786,0.60366952622972,"DPP6","dipeptidyl peptidase like 6",TRUE
+"1554796_at",0.728622545366091,0.210043730186345,1.290906181933,-5.15906515534328,0.361641212343171,"DPP6","dipeptidyl peptidase like 6",TRUE
+"228546_at",0.989669132517581,0.950451082440351,-0.0628479893714072,-5.93775982792282,-0.0514831528265516,"DPP6","dipeptidyl peptidase like 6",TRUE
+"238012_at",0.194325783329824,0.00206078724465451,-3.48926692196142,-1.29356555879301,-1.87092012559016,"DPP7","dipeptidyl peptidase 7",TRUE
+"241973_x_at",0.612420348961838,0.0843571687730079,-1.80703143198629,-4.4632755096474,-0.825738090015367,"DPP7","dipeptidyl peptidase 7",TRUE
+"224814_at",0.786221214160608,0.311597639653602,-1.03551741351253,-5.43048202662353,-0.741794209259151,"DPP7","dipeptidyl peptidase 7",TRUE
+"220939_s_at",0.637485146909712,0.108926656381803,-1.67030700550615,-4.66513712929223,-0.524269083341316,"DPP8","dipeptidyl peptidase 8",TRUE
+"227018_at",0.67565343307767,0.142174546761512,-1.52191776777703,-4.87041649809419,-0.389570979721345,"DPP8","dipeptidyl peptidase 8",TRUE
+"226343_at",0.69578040164665,0.165638366855653,-1.43363559415994,-4.98532208204504,-0.484451264826712,"DPP8","dipeptidyl peptidase 8",TRUE
+"230018_at",0.472863217746026,0.0258455267333874,-2.38877871963215,-3.48724522045961,-1.16140408880218,"DPP9","dipeptidyl peptidase 9",TRUE
+"231957_s_at",0.983498417373669,0.91958006011299,0.102119922586676,-5.93460542946378,0.0468485910289562,"DPP9","dipeptidyl peptidase 9",TRUE
+"226916_x_at",0.998347572104896,0.992364930578883,-0.00967784330244806,-5.93963786220219,-0.00366850975135691,"DPP9","dipeptidyl peptidase 9",TRUE
+"240301_at",0.729789891627758,0.212168283167146,1.28469488473769,-5.16627781386742,1.44713318984202,"DPPA2","developmental pluripotency associated 2",TRUE
+"241199_x_at",0.470726957161354,0.0253533399246363,2.39771676384456,-3.47097365785824,1.36326889102969,"DPPA4","developmental pluripotency associated 4",TRUE
+"219651_at",0.969642324744141,0.855201271401543,0.184626747340669,-5.92309456703012,0.188108222863322,"DPPA4","developmental pluripotency associated 4",TRUE
+"232985_s_at",0.999134201687551,0.997251973561829,-0.00348321542571735,-5.9396775713163,-0.00218632768349813,"DPPA4","developmental pluripotency associated 4",TRUE
+"241550_at",0.906845308365483,0.614984071342892,-0.510160138343346,-5.81370768970461,-0.368876175249833,"DPPA5","developmental pluripotency associated 5",TRUE
+"213071_at",0.470726957161354,0.0253600979780544,2.39759295683346,-3.47119927645902,1.0546664138623,"DPT","dermatopontin",TRUE
+"213068_at",0.805746717966166,0.345582312902817,0.963730428212632,-5.49716073842337,0.714511838044555,"DPT","dermatopontin",TRUE
+"207977_s_at",0.897300940949134,0.583501299004495,0.55641861776389,-5.7900026267177,0.435560083683883,"DPT","dermatopontin",TRUE
+"1560916_a_at",0.731054546207485,0.213729659286703,1.28016062978612,-5.1715243610357,0.777291193021645,"DPY19L1","dpy-19 like 1",TRUE
+"1570355_a_at",0.815775199549376,0.366713780827623,0.92150250140701,-5.53433857233229,0.813691607028935,"DPY19L1","dpy-19 like 1",TRUE
+"212792_at",0.823816057511545,0.391092264998073,0.874752690663472,-5.57370445499951,0.688752634296897,"DPY19L1","dpy-19 like 1",TRUE
+"1560915_at",0.855405088766616,0.468451793426285,-0.737677167709327,-5.67805922087586,-0.675131665102297,"DPY19L1","dpy-19 like 1",TRUE
+"215433_at",0.989400498103458,0.947760761304938,0.0662654898645836,-5.93754495675983,0.0382514816468795,"DPY19L1","dpy-19 like 1",TRUE
+"215102_at",0.652139736047968,0.121250707825058,1.61138563556425,-4.74842206641383,1.30329170756433,"DPY19L1P1","DPY19L1 pseudogene 1",TRUE
+"238784_at",0.937203701144735,0.721264717621446,0.36134457078346,-5.87628702640112,0.388597815397965,"DPY19L2","dpy-19 like 2",TRUE
+"230158_at",0.948863354656798,0.767248811803972,-0.299634498731073,-5.8960489067058,-0.372625249268417,"DPY19L2","dpy-19 like 2",TRUE
+"215143_at",0.94149227422279,0.738394266634844,-0.338202518117742,-5.88412578008191,-0.419967946271821,"DPY19L2P2","DPY19L2 pseudogene 2",TRUE
+"1557314_at",0.61760967235709,0.0881106963616628,-1.78409665124007,-4.49795217564503,-0.998372225294804,"DPY19L2P3","DPY19L2 pseudogene 3",TRUE
+"1557290_at",0.854092692629534,0.463460010301279,0.746083323972918,-5.67214145782039,0.620314463238815,"DPY19L2P4","DPY19L2 pseudogene 4",TRUE
+"225633_at",0.348891756023503,0.00920687854820257,-2.85307177531825,-2.60227119351185,-1.2198126607636,"DPY19L3","dpy-19 like 3 (C. elegans)",TRUE
+"1556613_s_at",0.712975827977365,0.187505921721034,1.36000826332037,-5.07684480970915,0.620456705094515,"DPY19L4","dpy-19 like 4 (C. elegans)",TRUE
+"213391_at",0.944785393058556,0.751506571866492,0.320614833234863,-5.88974002267721,0.119704173139633,"DPY19L4","dpy-19 like 4 (C. elegans)",TRUE
+"226721_at",0.982723176827697,0.91605329632516,0.106615719796112,-5.93414859325618,0.0462903486502881,"DPY19L4","dpy-19 like 4 (C. elegans)",TRUE
+"224129_s_at",0.751464513744428,0.244662910020706,1.19515427349975,-5.26692852596765,0.297202973464664,"DPY30","dpy-30, histone methyltransferase complex regulatory subunit",TRUE
+"1555522_s_at",0.594472468583746,0.0713149505521864,1.89428279126764,-4.32846465371485,0.654531504363845,"DPY30///MEMO1","dpy-30, histone methyltransferase complex regulatory subunit///mediator of cell motility 1",TRUE
+"219065_s_at",0.637349652490244,0.108180183133786,1.67405325898143,-4.65976468137502,0.643933011777658,"DPY30///MEMO1","dpy-30, histone methyltransferase complex regulatory subunit///mediator of cell motility 1",TRUE
+"204646_at",0.68033297785336,0.147731324956003,1.49999480297194,-4.89946638446097,2.17401235414753,"DPYD","dihydropyrimidine dehydrogenase",TRUE
+"1554534_at",0.731054546207485,0.213715945118105,1.28020034449216,-5.17147847610226,0.734176797344082,"DPYD","dihydropyrimidine dehydrogenase",TRUE
+"1554536_at",0.779400793584372,0.300669804083797,1.05976139300932,-5.40698721400785,1.26271652442481,"DPYD","dihydropyrimidine dehydrogenase",TRUE
+"206065_s_at",0.928591109195268,0.686095931196365,0.409512044343008,-5.85833138645972,0.229763219463075,"DPYS","dihydropyrimidinase",TRUE
+"200762_at",0.623667408398064,0.0951360708069576,1.74334176479678,-4.55877125666658,1.61704851047584,"DPYSL2","dihydropyrimidinase like 2",TRUE
+"201431_s_at",0.668235254207051,0.134429255802896,1.55367992890029,-4.82773490263081,1.23918745152718,"DPYSL3","dihydropyrimidinase like 3",TRUE
+"237292_at",0.912241810302154,0.631952707025842,0.485693828737736,-5.82543459964712,0.177592904887369,"DPYSL3","dihydropyrimidinase like 3",TRUE
+"201430_s_at",0.962555471240652,0.829070636482115,0.218459644216628,-5.91646527625546,0.198094093046428,"DPYSL3","dihydropyrimidinase like 3",TRUE
+"205493_s_at",0.776074974591224,0.293579809682239,-1.07582813648847,-5.3911484493472,-1.14326450637694,"DPYSL4","dihydropyrimidinase like 4",TRUE
+"205492_s_at",0.917102138198416,0.649604938422772,0.460556810410256,-5.83689601824402,0.347602569300638,"DPYSL4","dihydropyrimidinase like 4",TRUE
+"214301_s_at",0.975159323713639,0.87888947782029,-0.154146744225226,-5.92811688962862,-0.101794451323136,"DPYSL4","dihydropyrimidinase like 4",TRUE
+"222797_at",0.839519981963042,0.428104460889475,-0.807248731606009,-5.62717702909639,-0.594340269750829,"DPYSL5","dihydropyrimidinase like 5",TRUE
+"224100_s_at",0.980434477155705,0.908525465856375,-0.116219596485688,-5.93310686226678,-0.0638219325709315,"DPYSL5","dihydropyrimidinase like 5",TRUE
+"236055_at",0.771008055264122,0.279600880887899,-1.10834155108296,-5.35844644331706,-1.00069136260973,"DQX1","DEAQ-box RNA dependent ATPase 1",TRUE
+"209187_at",0.812302873476553,0.35981482160465,-0.935104619223146,-5.52253009250472,-0.373495626375885,"DR1","down-regulator of transcription 1",TRUE
+"1558236_at",0.857148066512338,0.471838927260489,0.732003405414578,-5.68201747151781,0.234921743781658,"DR1","down-regulator of transcription 1",TRUE
+"1558237_x_at",0.872120135033749,0.514977568533417,0.661714728442183,-5.72863605989717,0.393464363860068,"DR1","down-regulator of transcription 1",TRUE
+"216653_at",0.906845308365483,0.614987426016237,0.510155270572223,-5.81371007879057,0.340909887164281,"DR1","down-regulator of transcription 1",TRUE
+"216652_s_at",0.957658694776965,0.810070221576811,-0.243223112923784,-5.91091105719055,-0.0857412173635623,"DR1","down-regulator of transcription 1",TRUE
+"209188_x_at",0.993846586666397,0.97090118721149,0.0368923849447489,-5.93902058615995,0.0126531442667375,"DR1","down-regulator of transcription 1",TRUE
+"207654_x_at",0.995111934465262,0.977213072201565,0.0288873304850451,-5.93927704552256,0.0100570793156933,"DR1","down-regulator of transcription 1",TRUE
+"235585_at",0.999500506744552,0.998529760917745,-0.00186357440185119,-5.93968178922305,-0.000782376648584382,"DR1","down-regulator of transcription 1",TRUE
+"240838_s_at",0.765556218131589,0.265812880567171,-1.14158934270164,-5.32411383902193,-1.4045711669594,"DRAIC","downregulated RNA in cancer, inhibitor of cell invasion and migration",TRUE
+"239594_at",0.92781038684564,0.683418744152655,-0.413217962945133,-5.85685836586948,-0.492222342897808,"DRAIC","downregulated RNA in cancer, inhibitor of cell invasion and migration",TRUE
+"218627_at",0.786455312223125,0.312280655297011,-1.03402219743343,-5.43191501632436,-0.430643835128754,"DRAM1","DNA damage regulated autophagy modulator 1",TRUE
+"225228_at",0.493378740589161,0.0297696655729976,-2.32265592822823,-3.60655560790103,-0.806860501536988,"DRAM2","DNA damage regulated autophagy modulator 2",TRUE
+"225230_at",0.776955214137673,0.29573701477608,-1.07091057261041,-5.39601888332936,-0.397775629377014,"DRAM2","DNA damage regulated autophagy modulator 2",TRUE
+"203258_at",0.989427707117499,0.94780569108878,0.0662084092768151,-5.93754863900059,0.0298836191108762,"DRAP1","DR1 associated protein 1",TRUE
+"1558368_s_at",0.727074488271062,0.207188714011775,-1.299330059648,-5.14923600057441,-0.587368846052818,"DRAXIN","dorsal inhibitory axon guidance protein",TRUE
+"1556826_s_at",0.878281464330375,0.531239061018072,0.636082319757061,-5.74451574501121,0.404045829554456,"DRAXIN","dorsal inhibitory axon guidance protein",TRUE
+"1554340_a_at",0.976385464173016,0.88739911267829,-0.143235187502139,-5.92969567591301,-0.103511141395604,"DRAXIN","dorsal inhibitory axon guidance protein",TRUE
+"231133_at",0.956398858120188,0.802475015607955,0.253164807940758,-5.90851455068884,0.0918368263107481,"DRC1","dynein regulatory complex subunit 1",TRUE
+"1554584_at",0.724619150400903,0.201899371508136,1.31517757401482,-5.13059805259234,0.84678601063302,"DRC3","dynein regulatory complex subunit 3",TRUE
+"208140_s_at",0.833057833553471,0.410150194669927,0.839510197021555,-5.60212152604266,0.28484372832446,"DRC3","dynein regulatory complex subunit 3",TRUE
+"223905_at",0.911028479628096,0.628799569808751,-0.490217069971688,-5.82330897774579,-0.172690864923422,"DRC7","dynein regulatory complex subunit 7",TRUE
+"214652_at",0.975398143273847,0.882298421348307,-0.149773370568455,-5.92876355268259,-0.0645131860195383,"DRD1","dopamine receptor D1",TRUE
+"206590_x_at",0.604824625238112,0.0788561488299349,1.84229266508105,-4.40933917618234,0.531462950397167,"DRD2","dopamine receptor D2",TRUE
+"216938_x_at",0.682539393883246,0.150211081092765,1.49042844663013,-4.91203676939696,0.554971173466317,"DRD2","dopamine receptor D2",TRUE
+"216924_s_at",0.986889306520757,0.938735254118207,-0.0777366936551685,-5.93674058996484,-0.0567890986311888,"DRD2","dopamine receptor D2",TRUE
+"211624_s_at",0.993474831312851,0.969408849156944,-0.0387853854102148,-5.9389508152614,-0.0279105055634803,"DRD2","dopamine receptor D2",TRUE
+"211625_s_at",0.750020866111355,0.242906794783142,1.19975508611681,-5.26191007417222,0.433441927508272,"DRD3","dopamine receptor D3",TRUE
+"214559_at",0.87548954903345,0.522866914894119,0.649224406904125,-5.7364492449288,0.407071126933117,"DRD3","dopamine receptor D3",TRUE
+"208215_x_at",0.843816788557882,0.439664666412598,-0.786921059450743,-5.64249079706813,-0.351612198509348,"DRD4","dopamine receptor D4",TRUE
+"208486_at",0.728385463227073,0.209553656128109,1.29234584206502,-5.15738917699779,0.36745380951217,"DRD5","dopamine receptor D5",TRUE
+"202810_at",0.790361168948463,0.320067549345273,-1.01713584831768,-5.44796883160703,-0.274655832589001,"DRG1","developmentally regulated GTP binding protein 1",TRUE
+"203267_s_at",0.623841549898917,0.0954217993928604,1.74173954542863,-4.56114109213462,0.707693267362526,"DRG2","developmentally regulated GTP binding protein 2",TRUE
+"203268_s_at",0.771011793494937,0.279867143294054,1.10771139008327,-5.35908848554537,0.387804684940226,"DRG2","developmentally regulated GTP binding protein 2",TRUE
+"237325_at",0.557589172116298,0.0524055677351536,2.04977331885548,-4.0774099646566,1.16509574883815,"DRICH1","aspartate rich 1",TRUE
+"221108_at",0.959584210327095,0.817380151972765,-0.233678445518374,-5.91312204095879,-0.0868505085934688,"DRICH1","aspartate rich 1",TRUE
+"218269_at",0.657015752622694,0.12591431395027,1.59039379954729,-4.77753530682006,0.536640067727966,"DROSHA","drosha ribonuclease III",TRUE
+"207648_at",0.0694373323553232,0.000195080408059378,-4.45613046187251,0.784465909168785,-2.04246944497598,"DRP2","dystrophin related protein 2",TRUE
+"1569881_at",0.912421110187259,0.633239497368254,-0.483850854925658,-5.82629515210221,-0.398212602658448,"DRP2","dystrophin related protein 2",TRUE
+"1556627_at",0.924534749170361,0.67395074463528,0.426371895706042,-5.85152462407923,0.27317143206128,"DRP2","dystrophin related protein 2",TRUE
+"207324_s_at",0.910159094731364,0.626106563800861,-0.494088467229794,-5.82147438974904,-0.399683549143452,"DSC1","desmocollin 1",TRUE
+"204751_x_at",0.629618998226163,0.100522476351697,1.71380569711387,-4.60219737334191,1.45885044557813,"DSC2","desmocollin 2",TRUE
+"226817_at",0.660068911122272,0.128038014954257,1.58104857976281,-4.79040032491677,1.17717628619552,"DSC2","desmocollin 2",TRUE
+"231033_at",0.676684585211582,0.14360441229465,1.51621042683475,-4.87801164573039,1.70916741888362,"DSC2","desmocollin 2",TRUE
+"204750_s_at",0.695812999227098,0.165748946246704,1.4332442298571,-4.98581905499135,1.82876087052655,"DSC2","desmocollin 2",TRUE
+"206032_at",0.0723378272955723,0.000230939428906798,4.38729459963355,0.635867597696716,2.60481842644705,"DSC3","desmocollin 3",TRUE
+"206033_s_at",0.250356179889913,0.0035184078565453,3.26534419559911,-1.76335540623657,3.18817854616884,"DSC3","desmocollin 3",TRUE
+"244107_at",0.314126572995991,0.0066990687537874,2.9910389945797,-2.32605699241751,2.29162638861907,"DSC3","desmocollin 3",TRUE
+"237268_at",0.809109571194383,0.352317694223992,-0.950086124543751,-5.50934028933337,-1.04276151305195,"DSCAM","DS cell adhesion molecule",TRUE
+"240218_at",0.951339758531576,0.777344084441569,-0.286252600679263,-5.89985187663627,-0.386474198064863,"DSCAM","DS cell adhesion molecule",TRUE
+"211484_s_at",0.980832655742,0.91007970107265,0.11423584297637,-5.93332938892891,0.105443797814146,"DSCAM","DS cell adhesion molecule",TRUE
+"1562821_a_at",0.57336569501579,0.0602169497103965,-1.98033298071742,-4.19118391243808,-3.30820337744141,"DSCAM-AS1","DSCAM antisense RNA 1",TRUE
+"232059_at",0.748438284778152,0.241173336507104,-1.20432111458993,-5.25691299792764,-0.579527630966592,"DSCAML1","DS cell adhesion molecule like 1",TRUE
+"234908_s_at",0.980264692225439,0.907506310028383,-0.117520658427553,-5.93295883868606,-0.106901219862272,"DSCAML1","DS cell adhesion molecule like 1",TRUE
+"219000_s_at",0.942303845415102,0.740860699324644,0.334886117009473,-5.88520711273527,0.163363440660339,"DSCC1","DNA replication and sister chromatid cohesion 1",TRUE
+"216646_at",0.965620759643697,0.839310293781199,-0.205172884996268,-5.91920088781077,-0.0769695832503814,"DSCC1","DNA replication and sister chromatid cohesion 1",TRUE
+"1552468_a_at",0.635368778245437,0.106486510492121,1.68263490565822,-4.64742349741647,1.1018033498616,"DSCR10","Down syndrome critical region 10 (non-protein coding)",TRUE
+"1552467_at",0.937113154905832,0.720226372039736,0.362753733109204,-5.875793162178,0.172519533542196,"DSCR10","Down syndrome critical region 10 (non-protein coding)",TRUE
+"203635_at",0.903989791603451,0.606032772225567,0.523193894422543,-5.80723109880166,0.187222513481053,"DSCR3","DSCR3 arrestin fold containing",TRUE
+"217309_s_at",0.955925931146022,0.800916616786876,0.255207858455068,-5.90801024262651,0.0720122354515205,"DSCR3","DSCR3 arrestin fold containing",TRUE
+"207258_at",0.593339168375633,0.0705113943724621,1.90010243868814,-4.31931335706719,1.03310790543854,"DSCR4","Down syndrome critical region 4",TRUE
+"241224_x_at",0.255831879596455,0.00372623296163156,3.24113240770062,-1.8136487407285,3.60774490971919,"DSCR8","Down syndrome critical region 8",TRUE
+"230470_at",0.70933660268743,0.182137660084661,-1.37742337111206,-5.05555774546365,-0.71107007557447,"DSCR9","Down syndrome critical region 9 (non-protein coding)",TRUE
+"218854_at",0.175233958083293,0.00156162604938491,3.60432988924687,-1.04942112525634,4.33390677192196,"DSE","dermatan sulfate epimerase",TRUE
+"1558868_a_at",0.921919360038633,0.666951959158081,0.436144605762409,-5.84745560850236,0.173079822852901,"DSE","dermatan sulfate epimerase",TRUE
+"1558867_at",0.990259857399615,0.951446380044199,0.0615838647317218,-5.9378364273808,0.0313614755842242,"DSE","dermatan sulfate epimerase",TRUE
+"1557560_at",0.990623482682449,0.952681920058198,0.0600147517092912,-5.93792934342903,0.0432004038174352,"DSE","dermatan sulfate epimerase",TRUE
+"232235_at",0.746265133825325,0.238026843507633,1.2126726721737,-5.24773041434216,1.80061234766669,"DSEL","dermatan sulfate epimerase-like",TRUE
+"232825_s_at",0.924874199396311,0.675024425972504,0.4248764188083,-5.85213929639648,0.469977927989329,"DSEL","dermatan sulfate epimerase-like",TRUE
+"244852_at",0.994471114396429,0.974530992136495,0.0322886137363272,-5.93917570361089,0.0264880366440039,"DSEL","dermatan sulfate epimerase-like",TRUE
+"217671_at",0.851733415458562,0.456374335162736,0.758108795175236,-5.6635653691323,0.434256567974498,"DSERG1","Down syndrome encephalopathy related protein 1",TRUE
+"206642_at",0.663309898243682,0.131302067921219,-1.56693326821781,-4.80971948348864,-1.19896416505672,"DSG1","desmoglein 1",TRUE
+"1553105_s_at",0.636147339487472,0.107457366717555,1.67770167933652,-4.65452376304694,1.32046769027037,"DSG2","desmoglein 2",TRUE
+"217901_at",0.64513208805899,0.116235437854333,1.63472751206259,-4.71570310050653,1.12932571115755,"DSG2","desmoglein 2",TRUE
+"1556834_at",0.496742810480539,0.0303242606288958,2.31396606109167,-3.6220930789522,1.8618451745551,"DSG2-AS1","DSG2 antisense RNA 1",TRUE
+"243081_at",0.819018525257656,0.374399874665988,0.906547756272825,-5.54713727475328,0.329713614433482,"DSG2-AS1","DSG2 antisense RNA 1",TRUE
+"1556835_s_at",0.820288124919738,0.378509835823779,0.898634302976188,-5.55383159882926,0.313864782087262,"DSG2-AS1","DSG2 antisense RNA 1",TRUE
+"205595_at",0.118638058428056,0.000658713232817058,3.95934349263995,-0.288345007138141,3.29686833052873,"DSG3","desmoglein 3",TRUE
+"235075_at",0.170374697680568,0.0014168470311213,3.64455501024615,-0.96371450687101,4.70374892574026,"DSG3","desmoglein 3",TRUE
+"1561330_at",0.979588787486838,0.902820648856662,0.123505119132337,-5.93225678606872,0.08804571674994,"DSG4","desmoglein 4",TRUE
+"219512_at",0.778190689710014,0.297626804069979,-1.06662365897283,-5.40024842308677,-0.459056612135912,"DSN1","DSN1 homolog, MIS12 kinetochore complex component",TRUE
+"200606_at",0.686108994812404,0.154563769698145,1.47394340702469,-4.93354643353594,1.25534852038903,"DSP","desmoplakin",TRUE
+"221681_s_at",0.8552783609358,0.4676773142551,0.738977895222094,-5.67714769370653,0.485398168646271,"DSPP","dentin sialophosphoprotein",TRUE
+"216918_s_at",0.263648197061379,0.00397823068268199,3.21347385316302,-1.87096641935146,2.22636145468817,"DST","dystonin",TRUE
+"204455_at",0.575270671804438,0.060774343538696,1.97568976402429,-4.19869773480731,1.90379488928752,"DST","dystonin",TRUE
+"215810_x_at",0.581406183553129,0.0638590045968769,1.95065495222735,-4.23900340144016,0.576787850015714,"DST","dystonin",TRUE
+"215814_at",0.606138724709726,0.0797904411263249,-1.83615648092454,-4.41877892898417,-1.44691673827957,"DST","dystonin",TRUE
+"232098_at",0.615637099066718,0.0858471151213277,1.79782414050298,-4.47723528302716,1.77762894193163,"DST","dystonin",TRUE
+"215016_x_at",0.697817511728157,0.168739740696076,1.42273787094039,-4.99911899520928,0.950276128280779,"DST","dystonin",TRUE
+"212254_s_at",0.700963156261921,0.172717809555517,1.4089922362477,-5.01639818354746,1.02598729974309,"DST","dystonin",TRUE
+"212253_x_at",0.70190082585548,0.173419479655904,1.40659404838877,-5.01939872446703,1.57137909111454,"DST","dystonin",TRUE
+"220154_at",0.888726194792314,0.555147064119651,0.599154859310472,-5.76633085030376,0.356290051195405,"DST","dystonin",TRUE
+"1553191_at",0.995111934465262,0.977346998018827,-0.0287175017855516,-5.93928181024812,-0.0227875127964339,"DST","dystonin",TRUE
+"201021_s_at",0.578849863698044,0.0617969209767807,-1.96726860053533,-4.21229467710795,-0.548728440434969,"DSTN","destrin, actin depolymerizing factor",TRUE
+"201022_s_at",0.717937808890208,0.193802896410785,-1.34007456725025,-5.10093258025704,-0.390203144537395,"DSTN","destrin, actin depolymerizing factor",TRUE
+"230933_at",0.900692252557887,0.595879034382341,0.53809055202229,-5.79963404031028,0.243337486355943,"DSTN","destrin, actin depolymerizing factor",TRUE
+"211325_x_at",0.771855357662161,0.28205061975448,1.10256012201437,-5.36432471797764,0.415163595273535,"DSTNP2","destrin, actin depolymerizing factor pseudogene 2",TRUE
+"229017_s_at",0.606138724709726,0.0796739711968383,-1.83691800846538,-4.41760863763475,-0.557517507358201,"DSTYK","dual serine/threonine and tyrosine protein kinase",TRUE
+"214663_at",0.691063803085828,0.160747340651815,-1.45116020549145,-4.96295505466007,-0.500940096799269,"DSTYK","dual serine/threonine and tyrosine protein kinase",TRUE
+"211514_at",0.73223722457785,0.216019973050335,-1.27355550970956,-5.17913878467914,-0.731389717988896,"DSTYK","dual serine/threonine and tyrosine protein kinase",TRUE
+"211515_s_at",0.825584296889741,0.393003795064459,-0.871168593118654,-5.57664406740797,-0.327798968912216,"DSTYK","dual serine/threonine and tyrosine protein kinase",TRUE
+"234107_s_at",0.842224301155785,0.435808555462894,0.793664637702432,-5.63745126853629,0.48627168443911,"DTD1","D-tyrosyl-tRNA deacylase 1",TRUE
+"1552718_at",0.990810941805126,0.954471978331347,-0.0577416835293755,-5.93805969305243,-0.0273198878353185,"DTD1","D-tyrosyl-tRNA deacylase 1",TRUE
+"1553801_a_at",0.0550194051692779,9.12377191736155e-05,-4.7666235042588,1.45246283868058,-1.60237523518317,"DTD2","D-tyrosyl-tRNA deacylase 2 (putative)",TRUE
+"227158_at",0.0985170196189519,0.000437315232851461,-4.12679191178412,0.0730148329999745,-1.15736842969412,"DTD2","D-tyrosyl-tRNA deacylase 2 (putative)",TRUE
+"1564160_at",0.909955315434437,0.625143878524889,0.495474255642089,-5.8208142628172,0.361542087604313,"DTHD1","death domain containing 1",TRUE
+"218585_s_at",0.654728282657457,0.123657680339873,-1.60046888279449,-4.76359935853439,-0.690992364966506,"DTL","denticleless E3 ubiquitin protein ligase homolog",TRUE
+"222680_s_at",0.662575055303091,0.130414427459877,-1.57074277159048,-4.80451892786299,-0.513219122351769,"DTL","denticleless E3 ubiquitin protein ligase homolog",TRUE
+"205741_s_at",0.56559911410714,0.0565857732815008,-2.01154959566094,-4.14036045386899,-2.17272377398158,"DTNA","dystrobrevin alpha",TRUE
+"210091_s_at",0.765647257565398,0.265887067595858,-1.14140710650843,-5.32430446224098,-1.57500888910891,"DTNA","dystrobrevin alpha",TRUE
+"208430_s_at",0.794426378358553,0.326122200576848,-1.00420345158194,-5.46010190814405,-1.07013897206886,"DTNA","dystrobrevin alpha",TRUE
+"211493_x_at",0.812302873476553,0.358538772759684,-0.937639605667003,-5.52031180076327,-0.374435613080086,"DTNA","dystrobrevin alpha",TRUE
+"227084_at",0.815343387524998,0.366326663274835,-0.922261200305599,-5.53368411241575,-0.952529150989284,"DTNA","dystrobrevin alpha",TRUE
+"210611_s_at",0.891225909060826,0.560444948472354,-0.591086155241816,-5.77092986829752,-0.799974791723551,"DTNA","dystrobrevin alpha",TRUE
+"244142_at",0.922168942129244,0.667969526513368,0.434721070186646,-5.84805395364189,0.231109211877295,"DTNA","dystrobrevin alpha",TRUE
+"210736_x_at",0.957571530817866,0.808808432364565,-0.244872961600864,-5.91051995566688,-0.132478209267686,"DTNA","dystrobrevin alpha",TRUE
+"215295_at",0.69887421412603,0.170173814941893,1.41775302122904,-5.00540121558716,0.829304228734019,"DTNB","dystrobrevin beta",TRUE
+"214253_s_at",0.966089564318167,0.842083774425439,-0.201580671271063,-5.91991114175995,-0.183238243190445,"DTNB","dystrobrevin beta",TRUE
+"223763_at",0.784552021081681,0.308382395703089,1.04258725014113,-5.42368116204819,0.389531722983915,"DTNBP1","dystrobrevin binding protein 1",TRUE
+"223446_s_at",0.886074884554245,0.548774901523106,-0.608913189762266,-5.76068833434492,-0.273775654364201,"DTNBP1","dystrobrevin binding protein 1",TRUE
+"223445_at",0.986455005400648,0.937099016143417,-0.0798174118262651,-5.93658096591306,-0.0275943089874797,"DTNBP1","dystrobrevin binding protein 1",TRUE
+"232429_at",0.384135218769668,0.0124124310807057,-2.72155725147503,-2.86047659612421,-1.91514647075602,"DTWD1","DTW domain containing 1",TRUE
+"236649_at",0.67565343307767,0.142231420579104,-1.52168985752514,-4.87072022976711,-0.589575988733708,"DTWD1","DTW domain containing 1",TRUE
+"219291_at",0.753862100951903,0.247112907043641,-1.18877677387299,-5.27385718337843,-0.453665479154681,"DTWD1","DTW domain containing 1",TRUE
+"229984_at",0.766390367856479,0.266758723151067,-1.13926873087672,-5.32653924850774,-0.407253778283143,"DTWD1","DTW domain containing 1",TRUE
+"1555210_at",0.997674669021782,0.988680954803007,-0.0143477525284737,-5.93958321540332,-0.00781855516417362,"DTWD1","DTW domain containing 1",TRUE
+"244146_at",0.998347572104896,0.99290276380844,0.00899609206397935,-5.93964406296638,0.00652982045755568,"DTWD1","DTW domain containing 1",TRUE
+"231277_x_at",0.456430501481483,0.0222726397430745,-2.45760861413994,-3.36108543224635,-0.766163539021378,"DTWD2","DTW domain containing 2",TRUE
+"227336_at",0.938726197187622,0.726921185130473,-0.353681041543728,-5.87893959784951,-0.219318611578271,"DTX1","deltex E3 ubiquitin ligase 1",TRUE
+"179_at",0.347548509440726,0.00903912172701805,2.86110383830552,-2.58633404323548,0.815016538226381,"DTX2P1-UPK3BP1-PMS2P11","DTX2P1-UPK3BP1-PMS2P11 readthrough, transcribed pseudogene",TRUE
+"210707_x_at",0.93523910610914,0.71203240485267,-0.373900519127145,-5.87181972543484,-0.119361596453849,"DTX2P1-UPK3BP1-PMS2P11","DTX2P1-UPK3BP1-PMS2P11 readthrough, transcribed pseudogene",TRUE
+"235721_at",0.598790786356002,0.0757832177120109,-1.86293100885568,-4.37742522791472,-1.46587772343023,"DTX3","deltex E3 ubiquitin ligase 3",TRUE
+"49049_at",0.62282585384278,0.0933410761144847,-1.7535024835061,-4.54370509083115,-1.01096502531268,"DTX3","deltex E3 ubiquitin ligase 3",TRUE
+"221835_at",0.683108395823428,0.152239155063712,-1.48269979363084,-4.92214512193116,-0.799659864802187,"DTX3","deltex E3 ubiquitin ligase 3",TRUE
+"49051_g_at",0.810487508111288,0.354583652382661,-0.9455355820901,-5.51336694529412,-0.798543407307107,"DTX3","deltex E3 ubiquitin ligase 3",TRUE
+"222022_at",0.915639438262336,0.644372357860446,0.467975989724057,-5.83357518767219,0.144519222908548,"DTX3","deltex E3 ubiquitin ligase 3",TRUE
+"225415_at",0.630603891142543,0.101995692507226,1.70596274996259,-4.61363552204448,1.11145381907778,"DTX3L","deltex E3 ubiquitin ligase 3L",TRUE
+"212611_at",0.769258076576208,0.276588255300992,1.11550208942423,-5.35112815380587,0.963844191428736,"DTX4","deltex E3 ubiquitin ligase 4",TRUE
+"203270_at",0.555180272174837,0.0514157324484997,-2.05922174754418,-4.06172930112328,-0.709771965730567,"DTYMK","deoxythymidylate kinase",TRUE
+"1565693_at",0.627565787558134,0.099084738028358,1.72155472512174,-4.59085767326216,1.01003367196633,"DTYMK","deoxythymidylate kinase",TRUE
+"1553984_s_at",0.680708651141727,0.148655639500049,-1.49641379306399,-4.90417946577547,-0.492393678197534,"DTYMK","deoxythymidylate kinase",TRUE
+"1553983_at",0.982143525809546,0.914079286203963,-0.109133096886323,-5.93388420729513,-0.0325169732461283,"DTYMK","deoxythymidylate kinase",TRUE
+"1565694_at",0.991689960875868,0.961532052490813,-0.0487795166412608,-5.93852460910065,-0.0218138553241349,"DTYMK","deoxythymidylate kinase",TRUE
+"239466_at",0.890405697398587,0.558955202983072,0.593351023786827,-5.76964501718116,0.338709043280326,"DUBR","DPPA2 upstream binding RNA",TRUE
+"235606_at",0.94118897722809,0.736699476044349,0.340483599779263,-5.88337590239395,0.198944968833937,"DUBR","DPPA2 upstream binding RNA",TRUE
+"219597_s_at",0.0302501799075868,3.04299935055743e-05,5.21841809076542,2.4127285449169,3.70049269384168,"DUOX1","dual oxidase 1",TRUE
+"215800_at",0.330171916405281,0.00796996598442232,2.91590612816632,-2.47711151985371,1.43431563658405,"DUOX1","dual oxidase 1",TRUE
+"1565795_at",0.739189560382301,0.226373845432853,-1.2443495556248,-5.21240326745628,-0.758122159818444,"DUOX1","dual oxidase 1",TRUE
+"219727_at",0.52629147962869,0.0396796283378445,2.1858050953765,-3.8472200098428,1.57610328741054,"DUOX2","dual oxidase 2",TRUE
+"1555404_a_at",0.043795211728206,5.26205717148756e-05,4.99244975466132,1.93461979630148,2.59769411136113,"DUOXA1","dual oxidase maturation factor 1",TRUE
+"1554648_a_at",0.109433493286707,0.000532406204193217,4.04641621197062,-0.100542009113448,3.08609665209976,"DUOXA1","dual oxidase maturation factor 1",TRUE
+"230615_at",0.998870448604467,0.995792005968506,0.00533378834227444,-5.93966962415442,0.00330936309753405,"DUOXA2","dual oxidase maturation factor 2",TRUE
+"217912_at",0.529941484988545,0.0414051276249263,-2.16522981958171,-3.88263492698117,-0.882301812688544,"DUS1L","dihydrouridine synthase 1 like",TRUE
+"47105_at",0.737161440695888,0.223301697915876,-1.25290679732537,-5.20272542436469,-0.344357666786388,"DUS2","dihydrouridine synthase 2",TRUE
+"219486_at",0.902695356210077,0.60208367767105,-0.528973235893542,-5.80430836988465,-0.204207315514667,"DUS2","dihydrouridine synthase 2",TRUE
+"230145_at",0.559167054471987,0.0529355038673435,-2.04478017609912,-4.0856775148513,-1.37822226894686,"DUS3L","dihydrouridine synthase 3 like",TRUE
+"224966_s_at",0.676294804179428,0.142970418799927,-1.51873524892191,-4.87465449922309,-0.716871937978454,"DUS3L","dihydrouridine synthase 3 like",TRUE
+"205762_s_at",0.743553048228796,0.234197233472793,1.2229505748184,-5.23635437808727,0.5686241121394,"DUS4L","dihydrouridine synthase 4 like",TRUE
+"205761_s_at",0.962351204352784,0.82844240857299,0.219276105363027,-5.91629160374928,0.0896091582627587,"DUS4L","dihydrouridine synthase 4 like",TRUE
+"201044_x_at",0.54295328972902,0.0461330627708434,-2.11258483714162,-3.97229208311777,-1.56231699492083,"DUSP1","dual specificity phosphatase 1",TRUE
+"201041_s_at",0.729789891627758,0.212216360072972,-1.28455488519741,-5.16644004245742,-0.770103138606428,"DUSP1","dual specificity phosphatase 1",TRUE
+"226578_s_at",0.994174089523038,0.973452578134528,-0.0336563135621167,-5.93913177629427,-0.0110202149760781,"DUSP1","dual specificity phosphatase 1",TRUE
+"215501_s_at",0.429276772897071,0.0188277220193357,2.53447334039536,-3.2179504969275,2.14408874791978,"DUSP10","dual specificity phosphatase 10",TRUE
+"221563_at",0.585892284764425,0.0659160696947375,1.9345468481536,-4.26475131536161,1.64078223517602,"DUSP10","dual specificity phosphatase 10",TRUE
+"202703_at",0.757479140651,0.25364219633895,1.17200843999213,-5.2919202992182,0.318203098550727,"DUSP11","dual specificity phosphatase 11",TRUE
+"218576_s_at",0.851733415458562,0.456604262485425,-0.75771682428599,-5.66384695321595,-0.219615604415919,"DUSP12","dual specificity phosphatase 12",TRUE
+"219963_at",0.892780783477555,0.56597261917954,-0.582709473915477,-5.77564063229339,-0.244596635485137,"DUSP13","dual specificity phosphatase 13",TRUE
+"203367_at",0.89880856206786,0.588635357694812,0.54879342885367,-5.79404773337076,0.227054529375868,"DUSP14","dual specificity phosphatase 14",TRUE
+"234829_at",0.96261149778695,0.829922804628308,0.217352387143133,-5.91669977470993,0.184031009604829,"DUSP15","dual specificity phosphatase 15",TRUE
+"230402_at",0.994098505325585,0.972798478291715,0.0344859083436048,-5.93910424394594,0.0144756536766781,"DUSP15","dual specificity phosphatase 15",TRUE
+"1563505_at",0.801917957653237,0.339618941560655,0.975962811742812,-5.48610667836503,0.807482115505693,"DUSP16","dual specificity phosphatase 16",TRUE
+"224832_at",0.906476756086155,0.614049924374265,-0.51151611113199,-5.81304131721316,-0.32757204731849,"DUSP16","dual specificity phosphatase 16",TRUE
+"1555399_a_at",0.969866537515598,0.856043797508438,0.1835397549098,-5.92328916899223,0.0686602632722195,"DUSP16","dual specificity phosphatase 16",TRUE
+"224336_s_at",0.971216837324271,0.862114338260026,-0.175714394557725,-5.92465631886962,-0.0934333489358661,"DUSP16","dual specificity phosphatase 16",TRUE
+"227098_at",0.816800680706682,0.36864626514643,0.91772304591843,-5.5375913691186,0.31025634650376,"DUSP18","dual specificity phosphatase 18",TRUE
+"1553701_a_at",0.974869566704674,0.876696144952942,0.15696221941486,-5.92769075856646,0.0445002915824704,"DUSP18","dual specificity phosphatase 18",TRUE
+"1555598_a_at",0.819018525257656,0.373135018655621,0.90899468728366,-5.54505634047244,0.357484316665409,"DUSP19","dual specificity phosphatase 19",TRUE
+"1552705_at",0.973615804712521,0.87300465435475,0.161703753893603,-5.92695572256012,0.0916800694506135,"DUSP19","dual specificity phosphatase 19",TRUE
+"1552708_a_at",0.982822603044588,0.91627648001814,-0.106331147166454,-5.93417809260232,-0.0790166288509404,"DUSP19","dual specificity phosphatase 19",TRUE
+"204794_at",0.959451355429682,0.81672906679178,0.23452766250686,-5.91292889076998,0.25670405004631,"DUSP2","dual specificity phosphatase 2",TRUE
+"220515_at",0.782206338814045,0.304173907631478,1.05192028429524,-5.41463947346402,0.418843198454558,"DUSP21","dual specificity phosphatase 21",TRUE
+"218845_at",0.685154158710982,0.153746350636772,1.47701019717592,-4.92955950221811,0.679209952469149,"DUSP22","dual specificity phosphatase 22",TRUE
+"223402_at",0.915766032166572,0.644766800407633,-0.467415792125602,-5.83382774639982,-0.394852928570536,"DUSP23","dual specificity phosphatase 23",TRUE
+"219144_at",0.83083080573017,0.404679564470053,0.849517238190173,-5.59416324524746,0.593189068462275,"DUSP26","dual specificity phosphatase 26 (putative)",TRUE
+"232252_at",0.7768734672127,0.294954093520865,1.07269234041775,-5.39425649688785,0.5531561024617,"DUSP27","dual specificity phosphatase 27 (putative)",TRUE
+"229211_at",0.571884062749565,0.0599340773581162,-1.98270394935608,-4.18734252926209,-0.826071603579159,"DUSP28","dual specificity phosphatase 28",TRUE
+"201537_s_at",0.95643295620889,0.802614544038443,0.252981940925749,-5.90855949329461,0.0603466083284765,"DUSP3","dual specificity phosphatase 3",TRUE
+"201538_s_at",0.971826767527606,0.865024473115678,0.171967032091142,-5.92528998454913,0.0591577054578742,"DUSP3","dual specificity phosphatase 3",TRUE
+"201536_at",0.995111934465262,0.977384753832439,0.0286696245362079,-5.93928314841936,0.0102890103423725,"DUSP3","dual specificity phosphatase 3",TRUE
+"204015_s_at",0.941311073534434,0.737429664931212,0.339500586275036,-5.88369966729584,0.36605534798996,"DUSP4","dual specificity phosphatase 4",TRUE
+"204014_at",0.950870395622221,0.775462363604023,0.288742818037617,-5.89915723676347,0.440608474512148,"DUSP4","dual specificity phosphatase 4",TRUE
+"226034_at",0.961212424803935,0.824330852979089,0.224623381404976,-5.91513822417829,0.309238340308243,"DUSP4","dual specificity phosphatase 4",TRUE
+"209457_at",0.937632892550302,0.724073817819092,0.357536001559905,-5.87761230361888,0.238649249062746,"DUSP5","dual specificity phosphatase 5",TRUE
+"1553299_at",0.778686132916778,0.299397880066978,-1.06262365502516,-5.40418119147098,-1.16887582066462,"DUSP5P1","dual specificity phosphatase 5 pseudogene 1",TRUE
+"208891_at",0.841391443291102,0.431998913508328,0.800363163927776,-5.63240536310145,0.987919435807639,"DUSP6","dual specificity phosphatase 6",TRUE
+"208893_s_at",0.865345395265289,0.495028538007913,0.693782637076904,-5.70792383906908,1.16427659480316,"DUSP6","dual specificity phosphatase 6",TRUE
+"208892_s_at",0.878144724623572,0.530099069706465,0.637865141387796,-5.74343075979601,0.76809185545056,"DUSP6","dual specificity phosphatase 6",TRUE
+"214793_at",0.683017520100356,0.151432590546644,1.48576337932414,-4.91814330213556,1.49109193729057,"DUSP7","dual specificity phosphatase 7",TRUE
+"213848_at",0.813631136157676,0.364408779776321,0.926027906018079,-5.53042757945795,0.489948413233128,"DUSP7","dual specificity phosphatase 7",TRUE
+"205777_at",0.8288884913487,0.399659247185423,0.858776919487228,-5.58672101232938,0.62924049550212,"DUSP9","dual specificity phosphatase 9",TRUE
+"209932_s_at",0.46584896273628,0.0242168172364092,-2.41898480348473,-3.43212086104946,-0.784121329707933,"DUT","deoxyuridine triphosphatase",TRUE
+"208955_at",0.466300647363886,0.0243348724973171,-2.41673310690827,-3.43624321207956,-0.966832786568672,"DUT","deoxyuridine triphosphatase",TRUE
+"208956_x_at",0.540483367247649,0.0449567056010064,-2.12521209195731,-3.95091432662485,-0.52004344159355,"DUT","deoxyuridine triphosphatase",TRUE
+"208176_at",0.662855903464759,0.130668469146868,1.56965030648532,-4.80601132381475,1.0748159222869,"DUX1","double homeobox 1",TRUE
+"208582_s_at",0.445869317136885,0.0208765514745391,2.48732572553382,-3.30602148037717,2.11057448497371,"DUX1///DUX3///DUX5","double homeobox 1///double homeobox 3///double homeobox 5",TRUE
+"216473_x_at",0.929799592139474,0.690260097412505,0.403759312557531,-5.86059209989885,0.261516202581196,"DUX4L24///DBET///LOC100291626///DUX4///LOC100288289///DUX4L2///DUX4L3///DUX4L5///DUX4L6///DUX4L7///LOC652301///DUX4L4///DUX4L8///DUX4L1","double homeobox 4 like 24///D4Z4 binding element transcript (non-protein coding)///double homeobox protein 4-like///double homeobox 4///double homeobox protein 4-like protein 2-like///double homeobox 4 like 2///double homeobox 4 like 3///double homeobox 4 like 5///double homeobox 4 like 6///double homeobox 4 like 7///double homeobox protein 4-like protein 4-like///double homeobox 4 like 4///double homeobox 4 like 8///double homeobox 4 like 1",TRUE
+"208201_at",0.836764898086598,0.418757405421957,-0.823935661143387,-5.61433209170213,-0.494124192640895,"DUX4L24///DBET///LOC100291626///DUX4///LOC100288289///LOC100287823///LOC100133400///DUX4L2///DUX4L3///DUX4L5///DUX4L6///DUX4L7///LOC652301///DUX4L4///DUX4L8///DUX3///DUX4L1","double homeobox 4 like 24///D4Z4 binding element transcript (non-protein coding)///double homeobox protein 4-like///double homeobox 4///double homeobox protein 4-like protein 2-like///double homeobox protein 4-like protein 4///double homeobox protein 4-like protein 4-like///double homeobox 4 like 2///double homeobox 4 like 3///double homeobox 4 like 5///double homeobox 4 like 6///double homeobox 4 like 7///double homeobox protein 4-like protein 4-like///double homeobox 4 like 4///double homeobox 4 like 8///double homeobox 3///double homeobox 4 like 1",TRUE
+"242881_x_at",0.631399729846207,0.102744643739217,1.70201244834194,-4.61938173739624,2.07662067289027,"DUXAP10","double homeobox A pseudogene 10",TRUE
+"239010_at",0.791045390251277,0.321149236898173,1.01481298391885,-5.45015848019654,0.915335232372665,"DUXAP10","double homeobox A pseudogene 10",TRUE
+"203230_at",0.90427866743639,0.606831433253105,0.522027282340116,-5.80781728507356,0.180097126337994,"DVL1","dishevelled segment polarity protein 1",TRUE
+"57532_at",0.624995428438293,0.0963413163397885,1.73661107334366,-4.56871573317562,0.481166026636297,"DVL2","dishevelled segment polarity protein 2",TRUE
+"218759_at",0.735413789306046,0.220397020935756,1.26108074762269,-5.19342794253401,0.581421115574643,"DVL2","dishevelled segment polarity protein 2",TRUE
+"201907_x_at",0.322131160460075,0.00718349250674042,-2.96090785900645,-2.38681189820232,-1.62184209357065,"DVL3","dishevelled segment polarity protein 3",TRUE
+"201908_at",0.939356991756184,0.728411573360784,0.351665431792157,-5.87962792906976,0.139609246044886,"DVL3","dishevelled segment polarity protein 3",TRUE
+"204522_at",0.812302873476553,0.359808064913898,0.935118026088364,-5.522518375064,0.343569867289682,"DXO","decapping exoribonuclease",TRUE
+"215982_s_at",0.812302873476553,0.360866675283976,0.933019550735785,-5.52435053867577,0.325237874019924,"DXO","decapping exoribonuclease",TRUE
+"38157_at",0.877275291808937,0.526787534287681,0.643055873012037,-5.74025517609855,0.234837731442221,"DXO","decapping exoribonuclease",TRUE
+"1552993_at",0.99783553534859,0.989793663143122,0.0129372231692605,-5.93960196047265,0.010327370745143,"DYDC1","DPY30 domain containing 1",TRUE
+"239733_at",0.921312278448293,0.664959988837617,-0.438933948460704,-5.84627761479328,-0.326690360197759,"DYDC2","DPY30 domain containing 2",TRUE
+"223171_at",0.562643595171948,0.0552931556600138,-2.02309275735008,-4.12143277202525,-0.880246955364793,"DYM","dymeclin",TRUE
+"227730_at",0.899808883319249,0.593147346105851,-0.542119220113199,-5.79754384952883,-0.325496133606536,"DYM","dymeclin",TRUE
+"220774_at",0.932091525948902,0.700079428595566,-0.39024834954091,-5.8657777960793,-0.302775863010305,"DYM","dymeclin",TRUE
+"244768_at",0.716472449896956,0.192445042310637,1.34432944702056,-5.09581601074967,0.517971864492832,"DYNC1H1","dynein cytoplasmic 1 heavy chain 1",TRUE
+"236183_at",0.841967750949524,0.434239468373197,0.796419178752256,-5.63538113957141,0.582247607444828,"DYNC1H1","dynein cytoplasmic 1 heavy chain 1",TRUE
+"1556831_at",0.845566619252464,0.442872960105141,0.781337995337668,-5.64663241347042,0.259669682263556,"DYNC1H1","dynein cytoplasmic 1 heavy chain 1",TRUE
+"229115_at",0.854400503339099,0.465827579506638,0.742089674157066,-5.67496083335002,0.285667239993632,"DYNC1H1","dynein cytoplasmic 1 heavy chain 1",TRUE
+"229042_s_at",0.908248060681879,0.61888778690012,-0.504504084186371,-5.81646866456512,-0.357774481107145,"DYNC1H1","dynein cytoplasmic 1 heavy chain 1",TRUE
+"241084_x_at",0.93803622451021,0.725792125133607,-0.355208983189976,-5.87841521549008,-0.250680396793858,"DYNC1H1","dynein cytoplasmic 1 heavy chain 1",TRUE
+"211928_at",0.995126858395038,0.977693639957067,0.0282779359564659,-5.9392940122833,0.00789439754762888,"DYNC1H1","dynein cytoplasmic 1 heavy chain 1",TRUE
+"1569843_at",0.753445799992783,0.246662347185897,1.18994604443527,-5.27258927914345,0.944439102180127,"DYNC1I1","dynein cytoplasmic 1 intermediate chain 1",TRUE
+"205348_s_at",0.995111934465262,0.977277966628984,-0.0288050390272915,-5.93927935780547,-0.0204065260336748,"DYNC1I1","dynein cytoplasmic 1 intermediate chain 1",TRUE
+"236698_at",0.778974960380281,0.300074271282913,1.06110046815728,-5.40567529435656,0.546212985876227,"DYNC1I2","dynein cytoplasmic 1 intermediate chain 2",TRUE
+"242363_at",0.892780783477555,0.566072285733895,0.582558825697565,-5.77572475631725,0.491872272464734,"DYNC1I2","dynein cytoplasmic 1 intermediate chain 2",TRUE
+"211684_s_at",0.952807406768689,0.784054634334522,0.277386953003419,-5.90227645963996,0.0664830464471606,"DYNC1I2","dynein cytoplasmic 1 intermediate chain 2",TRUE
+"222479_s_at",0.900171779891306,0.594878952922409,0.539564414010007,-5.79887111598954,0.182369197079408,"DYNC1LI1","dynein cytoplasmic 1 light intermediate chain 1",TRUE
+"217976_s_at",0.969642324744141,0.85523622611818,-0.184581645689718,-5.92310266425908,-0.0822457008129565,"DYNC1LI1","dynein cytoplasmic 1 light intermediate chain 1",TRUE
+"213162_at",0.771011793494937,0.279695220904122,1.10811822751413,-5.35867401456213,0.534460521201548,"DYNC1LI2","dynein cytoplasmic 1 light intermediate chain 2",TRUE
+"203590_at",0.830635993561085,0.404005682440132,0.850755882086906,-5.59317207345852,0.37260180261702,"DYNC1LI2","dynein cytoplasmic 1 light intermediate chain 2",TRUE
+"224616_at",0.957868442073393,0.810495980532993,-0.242666568993216,-5.91104239459765,-0.0886337794561207,"DYNC1LI2","dynein cytoplasmic 1 light intermediate chain 2",TRUE
+"224614_at",0.988446943949097,0.944913697656835,-0.069882981383534,-5.93730512401168,-0.022054654993342,"DYNC1LI2","dynein cytoplasmic 1 light intermediate chain 2",TRUE
+"1565149_at",0.647518308302168,0.118406617875255,1.62452091804914,-4.73005462202395,1.50899302714022,"DYNC2H1","dynein cytoplasmic 2 heavy chain 1",TRUE
+"219469_at",0.778397054392363,0.298164281610404,1.06540796582231,-5.40144508172045,0.640144163724615,"DYNC2H1","dynein cytoplasmic 2 heavy chain 1",TRUE
+"1561939_at",0.904732507122945,0.609211375989727,0.518555213491496,-5.80955434906795,0.282592608608201,"DYNC2H1","dynein cytoplasmic 2 heavy chain 1",TRUE
+"1554324_s_at",0.814439884224271,0.365384470418603,0.92411000967117,-5.53208723758583,0.60866709543315,"DYNC2LI1","dynein cytoplasmic 2 light intermediate chain 1",TRUE
+"203763_at",0.941106542715586,0.736135856692677,-0.341242603738725,-5.88312528388151,-0.125712196310307,"DYNC2LI1","dynein cytoplasmic 2 light intermediate chain 1",TRUE
+"241757_x_at",0.97304633500821,0.86936694347055,0.166379925981367,-5.92620945032344,0.0580175229509043,"DYNC2LI1","dynein cytoplasmic 2 light intermediate chain 1",TRUE
+"203762_s_at",0.986342822130003,0.934013810429033,0.0837416964620758,-5.93626844402869,0.0407099774088344,"DYNC2LI1","dynein cytoplasmic 2 light intermediate chain 1",TRUE
+"200703_at",0.983364220761052,0.919080839590598,0.102756178560177,-5.9345419711075,0.0228483466680114,"DYNLL1","dynein light chain LC8-type 1",TRUE
+"225494_at",0.837368340567858,0.420970399852749,-0.81996398361691,-5.6174116693778,-0.326061958306981,"DYNLL2","dynein light chain LC8-type 2",TRUE
+"238467_at",0.974536463688956,0.875590425136005,-0.158382069567215,-5.92747294114784,-0.0916984637684362,"DYNLL2","dynein light chain LC8-type 2",TRUE
+"229106_at",0.991367768700244,0.959676226857923,-0.0511349029742315,-5.93840999889064,-0.0188472865533686,"DYNLL2","dynein light chain LC8-type 2",TRUE
+"217917_s_at",0.818852235468236,0.372626201203633,-0.909980569610514,-5.54421645698036,-0.357248916559037,"DYNLRB1","dynein light chain roadblock-type 1",TRUE
+"1554568_at",0.893600768892136,0.568680979662847,-0.578620548707605,-5.77791647433124,-0.411459374885817,"DYNLRB1","dynein light chain roadblock-type 1",TRUE
+"217918_at",0.895999830738594,0.576973350829729,-0.566162499721963,-5.78475475204584,-0.222998379970409,"DYNLRB1","dynein light chain roadblock-type 1",TRUE
+"1565612_at",0.903919439852106,0.60579738260486,-0.523537870609036,-5.80705801819326,-0.152558290952149,"DYNLRB1","dynein light chain roadblock-type 1",TRUE
+"1565611_at",0.992649913032249,0.965534096872343,0.0437011257476943,-5.93875333604579,0.014176494445385,"DYNLRB1","dynein light chain roadblock-type 1",TRUE
+"238116_at",0.540483367247649,0.0448001758168101,-2.12691468546854,-3.9480256736472,-2.24439704704303,"DYNLRB2","dynein light chain roadblock-type 2",TRUE
+"201999_s_at",0.96287357728432,0.831429138960412,0.215395823742559,-5.9171112420763,0.064833620368848,"DYNLT1","dynein light chain Tctex-type 1",TRUE
+"203303_at",0.980832655742,0.909944144609004,0.114408842131603,-5.93331013511173,0.0687803385563743,"DYNLT3","dynein light chain Tctex-type 3",TRUE
+"209033_s_at",0.801892820429336,0.339467875758826,-0.976274587190809,-5.48582327350588,-0.346546937225213,"DYRK1A","dual specificity tyrosine phosphorylation regulated kinase 1A",TRUE
+"239308_at",0.903906029494077,0.605527984463655,-0.523931622133432,-5.80685975583347,-0.236654749673772,"DYRK1A","dual specificity tyrosine phosphorylation regulated kinase 1A",TRUE
+"215234_at",0.9116561917482,0.630216303146761,0.488183458976969,-5.82426702192067,0.409901012141127,"DYRK1A","dual specificity tyrosine phosphorylation regulated kinase 1A",TRUE
+"211079_s_at",0.952041062962677,0.780594434734807,-0.28195551690983,-5.90103649844428,-0.161818668833969,"DYRK1A","dual specificity tyrosine phosphorylation regulated kinase 1A",TRUE
+"211541_s_at",0.980475398877931,0.908995290237283,-0.115619884502295,-5.93317453818818,-0.067964012439437,"DYRK1A","dual specificity tyrosine phosphorylation regulated kinase 1A",TRUE
+"217270_s_at",0.895213601869362,0.573258951346476,0.571731524628561,-5.7817157129464,0.237305634795585,"DYRK1B","dual specificity tyrosine phosphorylation regulated kinase 1B",TRUE
+"204954_s_at",0.926430328514448,0.680290041336164,-0.41755637153511,-5.85511736096902,-0.349685899988947,"DYRK1B","dual specificity tyrosine phosphorylation regulated kinase 1B",TRUE
+"202969_at",0.835952408568777,0.41690076714313,-0.82727797850856,-5.61172971440344,-0.382753076355419,"DYRK2","dual specificity tyrosine phosphorylation regulated kinase 2",TRUE
+"202971_s_at",0.957571530817866,0.808923566040268,0.244722390173157,-5.91055575807978,0.109167723307626,"DYRK2","dual specificity tyrosine phosphorylation regulated kinase 2",TRUE
+"202968_s_at",0.977858230085336,0.892604880339007,0.136568899009135,-5.93060331595244,0.0632716631907257,"DYRK2","dual specificity tyrosine phosphorylation regulated kinase 2",TRUE
+"202970_at",0.997438522031683,0.986985256862517,-0.0164973694444003,-5.93955092095903,-0.00587679867058277,"DYRK2","dual specificity tyrosine phosphorylation regulated kinase 2",TRUE
+"210151_s_at",0.711902920992134,0.185379704379569,-1.36685815016613,-5.06849887990156,-1.00949121605343,"DYRK3","dual specificity tyrosine phosphorylation regulated kinase 3",TRUE
+"1560785_at",0.853460708803218,0.461879887143046,0.748755460924263,-5.67024701727997,0.248710119087333,"DYRK3","dual specificity tyrosine phosphorylation regulated kinase 3",TRUE
+"212954_at",0.919372089675945,0.656970142537928,-0.450157998694725,-5.84146300147227,-0.212162718965624,"DYRK4","dual specificity tyrosine phosphorylation regulated kinase 4",TRUE
+"218660_at",0.141625548869688,0.000942875167600665,3.8122940395623,-0.604703637686662,2.44691948917735,"DYSF","dysferlin",TRUE
+"235273_at",0.99783553534859,0.989550568893867,0.0132453802079843,-5.93959803070759,0.0113056518048529,"DYX1C1","dyslexia susceptibility 1 candidate 1",TRUE
+"214151_s_at",0.829803290928719,0.401491224184373,-0.855389348567415,-5.58945240574688,-0.372145099592805,"DYX1C1-CCPG1///CCPG1","DYX1C1-CCPG1 readthrough (NMD candidate)///cell cycle progression 1",TRUE
+"214152_at",0.839508810008021,0.426180771141055,-0.810664273267858,-5.62456794501711,-0.328289169478818,"DYX1C1-CCPG1///CCPG1","DYX1C1-CCPG1 readthrough (NMD candidate)///cell cycle progression 1",TRUE
+"222156_x_at",0.897011777275924,0.582651237067661,-0.557684355806541,-5.78932591875875,-0.285787433674956,"DYX1C1-CCPG1///CCPG1","DYX1C1-CCPG1 readthrough (NMD candidate)///cell cycle progression 1",TRUE
+"221511_x_at",0.990810941805126,0.955660140154897,-0.0562330938915469,-5.93814342614695,-0.0275119259648253,"DYX1C1-CCPG1///CCPG1","DYX1C1-CCPG1 readthrough (NMD candidate)///cell cycle progression 1",TRUE
+"241713_s_at",0.986409038173422,0.935911390293268,-0.081327879074912,-5.93646244955406,-0.0380746775836354,"DYX1C1-CCPG1///DYX1C1","DYX1C1-CCPG1 readthrough (NMD candidate)///dyslexia susceptibility 1 candidate 1",TRUE
+"1554818_s_at",0.673729302435703,0.140340247378879,-1.52930880112692,-4.8605469871377,-0.810735895144496,"DZANK1","double zinc ribbon and ankyrin repeat domains 1",TRUE
+"219951_s_at",0.994304286761558,0.974122418012138,-0.0328067807781502,-5.93915927567008,-0.0156948693674064,"DZANK1","double zinc ribbon and ankyrin repeat domains 1",TRUE
+"204557_s_at",0.56861088242915,0.0582446784612493,1.99707415871538,-4.16399407994789,3.34895639584011,"DZIP1","DAZ interacting zinc finger protein 1",TRUE
+"204556_s_at",0.725225714005638,0.203884562443223,1.30919227912791,-5.13765970718752,1.246300615186,"DZIP1","DAZ interacting zinc finger protein 1",TRUE
+"239785_at",0.812302873476553,0.357309004178225,0.940088396902201,-5.51816369975762,0.313563184591238,"DZIP1L","DAZ interacting zinc finger protein 1 like",TRUE
+"207231_at",0.816199380744005,0.367233740581665,-0.920484288848346,-5.53521611123784,-0.431616869739019,"DZIP3","DAZ interacting zinc finger protein 3",TRUE
+"213186_at",0.975242094553739,0.879726576115881,-0.153072539198484,-5.92827744588185,-0.0739839236859083,"DZIP3","DAZ interacting zinc finger protein 3",TRUE
+"207232_s_at",0.986865108460856,0.9385461711888,0.0779771223694533,-5.93672236058616,0.0401613818965689,"DZIP3","DAZ interacting zinc finger protein 3",TRUE
+"204947_at",0.841641983271935,0.433511514333758,-0.797699192841747,-5.63441687100203,-0.360704689264525,"E2F1","E2F transcription factor 1",TRUE
+"2028_s_at",0.975265330414469,0.880447599157025,-0.152147435404381,-5.92841481888406,-0.0517736384394638,"E2F1","E2F transcription factor 1",TRUE
+"228361_at",0.767727587789514,0.27015410772877,-1.13098767394481,-5.33515878831812,-0.392427911208708,"E2F2","E2F transcription factor 2",TRUE
+"207042_at",0.917806614232276,0.650923749517434,0.458691042235833,-5.8377229566205,0.287320565732499,"E2F2","E2F transcription factor 2",TRUE
+"235582_at",0.918141489589102,0.652280329069117,0.456773564888934,-5.83856938583498,0.142487776334771,"E2F2","E2F transcription factor 2",TRUE
+"203692_s_at",0.734730148360473,0.219653564669721,1.26318613676028,-5.19102477434358,0.427051342190907,"E2F3","E2F transcription factor 3",TRUE
+"203693_s_at",0.854593182713431,0.46620852054492,0.741448224704088,-5.67541233684893,0.249587521754087,"E2F3","E2F transcription factor 3",TRUE
+"202248_at",0.906507435035949,0.614584684077047,0.510739755235968,-5.81342305673954,0.194754830373729,"E2F4","E2F transcription factor 4",TRUE
+"38707_r_at",0.955904644595647,0.80066871113834,-0.255532963249961,-5.90792962203384,-0.0573147453212801,"E2F4","E2F transcription factor 4",TRUE
+"221586_s_at",0.986889306520757,0.939513950848685,0.0767465898503725,-5.93681506703746,0.0742812344009263,"E2F5","E2F transcription factor 5",TRUE
+"222051_s_at",0.987967825391489,0.942427722631655,0.0730424520649005,-5.93708523569144,0.0295495355256508,"E2F5","E2F transcription factor 5",TRUE
+"203957_at",0.9330573785522,0.704399113884395,-0.384328143180735,-5.86799525945936,-0.13584559901914,"E2F6","E2F transcription factor 6",TRUE
+"241725_at",0.647754107214051,0.118896924162148,1.62223775617972,-4.73325550134406,0.670441457784014,"E2F7","E2F transcription factor 7",TRUE
+"228033_at",0.711977799428804,0.185671811762518,1.36591342308824,-5.06965201704065,0.716519692445058,"E2F7","E2F transcription factor 7",TRUE
+"219990_at",0.769258076576208,0.275259182426852,1.11867914991164,-5.3478677258188,0.478741317739759,"E2F8","E2F transcription factor 8",TRUE
+"218524_at",0.540483367247649,0.0450120030217319,-2.1246118915113,-3.95193228865096,-0.739205628996409,"E4F1","E4F transcription factor 1",TRUE
+"226952_at",0.525405708458677,0.0393148880502722,-2.19025793659953,-3.83952839712024,-0.862503530019318,"EAF1","ELL associated factor 1",TRUE
+"1568673_s_at",0.808257777979515,0.350600137941178,-0.953548562044881,-5.50626460454243,-0.978414139773357,"EAF2","ELL associated factor 2",TRUE
+"1568672_at",0.970540753946729,0.859746368641638,-0.178765513177826,-5.92413032729891,-0.166210272696742,"EAF2","ELL associated factor 2",TRUE
+"219551_at",0.985498770484702,0.930215498982681,0.0885748871313085,-5.93586294410758,0.0776673385452753,"EAF2","ELL associated factor 2",TRUE
+"202623_at",0.66003015172657,0.127796335257324,-1.5821055497494,-4.78894822707681,-0.660280195598363,"EAPP","E2F associated phosphoprotein",TRUE
+"1563796_s_at",0.208781905890222,0.00240658909462242,-3.42462937487077,-1.42996594242502,-0.96869184025523,"EARS2","glutamyl-tRNA synthetase 2, mitochondrial",TRUE
+"225993_at",0.525721484032079,0.0394327170739014,-2.18881536893953,-3.84202127074144,-0.64547978726795,"EARS2","glutamyl-tRNA synthetase 2, mitochondrial",TRUE
+"227374_at",0.657015752622694,0.125405746791837,-1.59265116576442,-4.7744188544991,-0.576671939176261,"EARS2","glutamyl-tRNA synthetase 2, mitochondrial",TRUE
+"1555437_at",0.819018525257656,0.373526948540954,0.90823589227607,-5.54570219357694,0.34349964381046,"EARS2","glutamyl-tRNA synthetase 2, mitochondrial",TRUE
+"204278_s_at",0.695439932196858,0.164903847326756,-1.4362405637064,-4.98201134212909,-0.59017777861499,"EBAG9","estrogen receptor binding site associated, antigen, 9",TRUE
+"204274_at",0.748159087668676,0.240177198111762,-1.20695618152311,-5.25402167219507,-0.471540401082047,"EBAG9","estrogen receptor binding site associated, antigen, 9",TRUE
+"227646_at",0.774641130415354,0.291055377085004,-1.0816158465101,-5.38539067222628,-1.1542705942839,"EBF1","early B-cell factor 1",TRUE
+"233261_at",0.829044392052913,0.400242130086763,-0.857698011056162,-5.58759202570642,-0.866603788490644,"EBF1","early B-cell factor 1",TRUE
+"232204_at",0.97897951922649,0.898096426815685,0.129543510350664,-5.93151312453524,0.133031349708328,"EBF1","early B-cell factor 1",TRUE
+"229487_at",0.990810941805126,0.954351757147718,0.0578943339909046,-5.93805109685201,0.0322805391857459,"EBF1","early B-cell factor 1",TRUE
+"220392_at",0.579119470758542,0.0623023452583767,-1.96315173081069,-4.21892748619419,-0.978327814441873,"EBF2","early B-cell factor 2",TRUE
+"1562477_at",0.68806049531767,0.157448127435691,-1.46322595705816,-4.94742681662008,-1.15239869934203,"EBF2","early B-cell factor 2",TRUE
+"244885_at",0.907698187028963,0.617068750135885,0.507137582373776,-5.81518687092756,0.482625022069349,"EBF2","early B-cell factor 2",TRUE
+"1559796_at",0.87045636854107,0.509116117238118,0.671063391278825,-5.72269473896893,0.310526427538428,"EBF3","early B-cell factor 3",TRUE
+"227242_s_at",0.967106491969364,0.846721807201121,0.195579521204875,-5.92106981372724,0.224850005661043,"EBF3","early B-cell factor 3",TRUE
+"227243_s_at",0.991059530537351,0.958332165084797,-0.0528409505540745,-5.93832361111305,-0.0294003063636827,"EBF3","early B-cell factor 3",TRUE
+"233850_s_at",0.902770867950228,0.602317614380044,-0.528630372232936,-5.80448263508855,-0.195355989597022,"EBF4","early B-cell factor 4",TRUE
+"219424_at",0.523369751179323,0.0388454867573374,2.1960439719705,-3.8295195193258,1.18146943442529,"EBI3","Epstein-Barr virus induced 3",TRUE
+"219906_at",0.691982758723738,0.161456315556264,-1.44859352949834,-4.96624479935583,-1.16474914825125,"EBLN2","endogenous Bornavirus-like nucleoprotein 2",TRUE
+"225635_s_at",0.732963666545614,0.217267543702586,-1.2699802455557,-5.18324634476979,-0.55174028852827,"EBLN3P","endogenous Bornavirus-like nucleoprotein 3, pseudogene",TRUE
+"226635_at",0.855557411779543,0.468846644489056,-0.737014510387269,-5.67852301379032,-0.266400755893397,"EBLN3P","endogenous Bornavirus-like nucleoprotein 3, pseudogene",TRUE
+"225640_at",0.89390639630277,0.569601819685647,-0.57723258723445,-5.77868546827225,-0.268461132392392,"EBLN3P","endogenous Bornavirus-like nucleoprotein 3, pseudogene",TRUE
+"202735_at",0.785553614313586,0.311064704514187,-1.03668568740623,-5.42936107430368,-0.339992635911507,"EBP","emopamil binding protein (sterol isomerase)",TRUE
+"213787_s_at",0.804658857755908,0.343658994681534,-0.967659778802282,-5.49362377225496,-0.312645992113653,"EBP","emopamil binding protein (sterol isomerase)",TRUE
+"213789_at",0.969021613088792,0.853713801204829,-0.186546376765722,-5.92274810255158,-0.0946994670490628,"EBP","emopamil binding protein (sterol isomerase)",TRUE
+"231320_at",0.973071267819624,0.869655882005847,0.166008366383759,-5.92626952364241,0.0661465745507712,"EBP","emopamil binding protein (sterol isomerase)",TRUE
+"223306_at",0.876278327062923,0.524949187310755,0.645945109268816,-5.73847688751808,0.251070129558085,"EBPL","emopamil binding protein like",TRUE
+"203013_at",0.993389821646562,0.968843508906837,-0.0395025455703614,-5.93892347112881,-0.0143673430208064,"ECD","ecdysoneless cell cycle regulator",TRUE
+"201750_s_at",0.743323328391634,0.233540850260058,1.2247249164172,-5.23438205452109,0.638066964858565,"ECE1","endothelin converting enzyme 1",TRUE
+"201749_at",0.789795896476304,0.318504872024771,1.02050132134276,-5.44478833687443,0.394239770360679,"ECE1","endothelin converting enzyme 1",TRUE
+"206728_at",0.412437259854273,0.016448629659042,2.59565132075927,-3.10241947046636,1.97261634676815,"ECE2","endothelin converting enzyme 2",TRUE
+"227103_s_at",0.846236060228849,0.444190739689213,-0.779051965943836,-5.64832021011798,-0.309676723832686,"ECE2","endothelin converting enzyme 2",TRUE
+"1555306_a_at",0.8552783609358,0.467662256292306,0.739003197506946,-5.67712994720216,0.168430647165993,"ECE2","endothelin converting enzyme 2",TRUE
+"219914_at",0.979803152416153,0.903874008259093,0.122159388655198,-5.93241769124885,0.0414559019912746,"ECEL1","endothelin converting enzyme like 1",TRUE
+"200789_at",0.983498417373669,0.919429685027263,-0.102311570900792,-5.93458635644644,-0.0638080909080667,"ECH1","enoyl-CoA hydratase 1",TRUE
+"233124_s_at",0.601115828839805,0.0768064962098743,1.85597884895654,-4.38820386137785,2.76404922382575,"ECHDC1","ethylmalonyl-CoA decarboxylase 1",TRUE
+"223088_x_at",0.622434989367596,0.0928692386532027,1.75620113707727,-4.53969270714553,2.93191863168165,"ECHDC1","ethylmalonyl-CoA decarboxylase 1",TRUE
+"219974_x_at",0.634743115037769,0.105726667556451,1.68652255103856,-4.64181700495332,2.79470021242043,"ECHDC1","ethylmalonyl-CoA decarboxylase 1",TRUE
+"223087_at",0.647754107214051,0.119151907772179,1.62105351429263,-4.73491438133726,3.03094398146066,"ECHDC1","ethylmalonyl-CoA decarboxylase 1",TRUE
+"218552_at",0.632949074657601,0.103725094401946,-1.69687793700006,-4.62683557377044,-0.628654110493072,"ECHDC2","enoyl-CoA hydratase domain containing 2",TRUE
+"235305_s_at",0.841967750949524,0.434357090599789,0.796212479523594,-5.63553671501437,0.259702466751877,"ECHDC2","enoyl-CoA hydratase domain containing 2",TRUE
+"219298_at",0.914910510855952,0.641724034776266,0.471741157183868,-5.83187002069266,0.269836194700872,"ECHDC3","enoyl-CoA hydratase domain containing 3",TRUE
+"201135_at",0.975265330414469,0.880200673959053,-0.152464235781791,-5.92836786925682,-0.0580508815250234,"ECHS1","enoyl-CoA hydratase, short chain 1",TRUE
+"209759_s_at",0.900841249235227,0.596655951688254,-0.53694640826104,-5.80022489139716,-0.294825916517279,"ECI1","enoyl-CoA delta isomerase 1",TRUE
+"218025_s_at",0.900250794823241,0.59509582490172,0.539244698105027,-5.79903678485545,0.53157599145791,"ECI2","enoyl-CoA delta isomerase 2",TRUE
+"209365_s_at",0.615821255316333,0.0863916438446461,1.79449357725301,-4.48227222409631,0.925409304216879,"ECM1","extracellular matrix protein 1",TRUE
+"1568779_a_at",0.835289077598304,0.414495381211081,0.831622135075371,-5.60833255765973,0.287622890552846,"ECM2","extracellular matrix protein 2",TRUE
+"206101_at",0.92247975200053,0.668712628400749,0.433682077330384,-5.84848945394249,0.268100978018969,"ECM2","extracellular matrix protein 2",TRUE
+"216667_at",0.871619256677111,0.513087622792004,-0.664722570118954,-5.72673321072139,-0.39147619658794,"ECRP","ribonuclease A family member 2 pseudogene",TRUE
+"227779_at",0.817889575750373,0.370750638210684,0.913622374306579,-5.54110668296782,0.605255168399373,"ECSCR","endothelial cell surface expressed chemotaxis and apoptosis regulator",TRUE
+"227780_s_at",0.941595310742151,0.738513200839854,-0.33804250897922,-5.88417819401569,-0.226324481450881,"ECSCR","endothelial cell surface expressed chemotaxis and apoptosis regulator",TRUE
+"228339_at",0.960819760730297,0.82185137704998,-0.227851289312839,-5.91442859678599,-0.226783668478806,"ECSCR","endothelial cell surface expressed chemotaxis and apoptosis regulator",TRUE
+"218225_at",0.791045390251277,0.321123996429662,1.01486712412207,-5.45010749647854,0.575662836397651,"ECSIT","ECSIT signalling integrator",TRUE
+"219787_s_at",0.673870607802125,0.140443205293391,1.52889185194558,-4.86110476639494,0.495639969329726,"ECT2","epithelial cell transforming 2",TRUE
+"234992_x_at",0.712975827977365,0.187544917384005,1.359883207533,-5.07699685305075,0.509582477950193,"ECT2","epithelial cell transforming 2",TRUE
+"237241_at",0.855350972626085,0.467848310318568,0.738690599953402,-5.67734915629732,0.346324851247821,"ECT2","epithelial cell transforming 2",TRUE
+"211127_x_at",0.61299046462692,0.0846022139199769,1.80550754206107,-4.46558954428573,1.59421080124344,"EDA","ectodysplasin A",TRUE
+"206217_at",0.627092759817312,0.0988306927275152,-1.7229339143994,-4.58883540541711,-0.539586496317566,"EDA","ectodysplasin A",TRUE
+"211129_x_at",0.683017520100356,0.151496294264089,1.48552093022181,-4.91846024460533,0.780268054065194,"EDA","ectodysplasin A",TRUE
+"211128_at",0.711902920992134,0.185548254294808,-1.36631288640991,-5.06916451178738,-0.943767731489569,"EDA","ectodysplasin A",TRUE
+"211131_s_at",0.7995040428866,0.335023998657062,-0.985488955036372,-5.47741015436762,-0.669066022580548,"EDA","ectodysplasin A",TRUE
+"211130_x_at",0.982909728377256,0.917022303389715,-0.105380242629954,-5.93427609391444,-0.0299079742283457,"EDA","ectodysplasin A",TRUE
+"221399_at",0.725583196024696,0.204428957104769,1.30755886996849,-5.13958212710219,0.682457792637482,"EDA2R","ectodysplasin A2 receptor",TRUE
+"220048_at",0.779352872002251,0.300508774532263,1.06012328676367,-5.40663280566393,0.372769272673621,"EDAR","ectodysplasin A receptor",TRUE
+"1553430_a_at",0.911730272337063,0.630883037738566,0.487227135541664,-5.82471620513901,0.448447011049093,"EDARADD","EDAR associated death domain",TRUE
+"226042_at",0.661974206478491,0.129605435149885,-1.57423350952648,-4.79974483870268,-0.431976247727789,"EDC3","enhancer of mRNA decapping 3",TRUE
+"219207_at",0.864894115958506,0.493668985618695,-0.69599452806059,-5.7064606901853,-0.246877023203941,"EDC3","enhancer of mRNA decapping 3",TRUE
+"202496_at",0.623667408398064,0.0952213977576752,-1.74286286425295,-4.55947976536564,-0.537410954388239,"EDC4","enhancer of mRNA decapping 4",TRUE
+"217568_at",0.735615890266908,0.220608453402371,1.26048298788288,-5.19410962170797,0.558392318159325,"EDDM3A","epididymal protein 3A",TRUE
+"208143_s_at",0.74371414757151,0.2344889879229,1.22216311009318,-5.23722891663364,0.899577567179729,"EDDM3A","epididymal protein 3A",TRUE
+"208142_at",0.918175971329156,0.652522094960506,-0.456432020020891,-5.83871978887463,-0.306258450819049,"EDDM3A","epididymal protein 3A",TRUE
+"220759_at",0.777463110382572,0.296319782471042,1.06958650325574,-5.39732685242287,0.486623433927094,"EDDM3B","epididymal protein 3B",TRUE
+"203279_at",0.620223198657182,0.090211360681798,1.77162635465201,-4.5166712843063,0.557923895600833,"EDEM1","ER degradation enhancing alpha-mannosidase like protein 1",TRUE
+"218282_at",0.93919895813272,0.727833812470118,-0.352446622302488,-5.87936161363874,-0.195917991533303,"EDEM2","ER degradation enhancing alpha-mannosidase like protein 2",TRUE
+"220926_s_at",0.746695026721983,0.238573670266234,-1.2112153107668,-5.24933675455241,-0.479734729345065,"EDEM3","ER degradation enhancing alpha-mannosidase like protein 3",TRUE
+"223243_s_at",0.94838899137468,0.764720051213099,-0.302995193285075,-5.89506677906777,-0.137045716584655,"EDEM3","ER degradation enhancing alpha-mannosidase like protein 3",TRUE
+"220342_x_at",0.986421906591669,0.936283417477118,-0.0808547002187042,-5.93649981560128,-0.0344097909145251,"EDEM3","ER degradation enhancing alpha-mannosidase like protein 3",TRUE
+"209058_at",0.615821255316333,0.0864032653180557,-1.79442269319062,-4.48237935110035,-0.540941733873666,"EDF1","endothelial differentiation related factor 1",TRUE
+"209059_s_at",0.62110896023334,0.0913345268038843,-1.76506097301181,-4.52648789164947,-0.534453757791169,"EDF1","endothelial differentiation related factor 1",TRUE
+"225275_at",0.466300647363886,0.0243237370519707,2.41694506350779,-3.43585525671403,3.67719911130672,"EDIL3","EGF like repeats and discoidin domains 3",TRUE
+"1558643_s_at",0.508651764521346,0.0337147507018813,2.26380843857084,-3.71110955205013,1.639579838326,"EDIL3","EGF like repeats and discoidin domains 3",TRUE
+"207379_at",0.596689559015396,0.0730385164062587,1.88199123558055,-4.34772827761669,2.04298294668049,"EDIL3","EGF like repeats and discoidin domains 3",TRUE
+"1564630_at",0.8920930097751,0.56265876001056,0.587726233640146,-5.77282718629866,0.430168655490356,"EDN1","endothelin 1",TRUE
+"222802_at",0.90875136974978,0.62094270548664,-0.5015334311468,-5.81790674447065,-0.424291017020231,"EDN1","endothelin 1",TRUE
+"218995_s_at",0.956084625435459,0.801467336764214,-0.254485741839696,-5.90818895068393,-0.207052997597303,"EDN1","endothelin 1",TRUE
+"206758_at",0.51356204611816,0.0345286526114377,-2.2524569587231,-3.73109548550228,-1.57680704067224,"EDN2","endothelin 2",TRUE
+"208399_s_at",0.714590421965913,0.189979231142786,-1.35211684105741,-5.08641634431628,-0.855019761219246,"EDN3","endothelin 3",TRUE
+"217154_s_at",0.803135302652907,0.341113797131608,0.972882780271781,-5.488902000442,0.521953211891872,"EDN3","endothelin 3",TRUE
+"204464_s_at",0.7974001826642,0.330629606321296,0.994683848557415,-5.46894314819682,0.945415018582616,"EDNRA","endothelin receptor type A",TRUE
+"216235_s_at",0.848364007856994,0.448379967719132,0.771812000950208,-5.653634757976,0.548851433137036,"EDNRA","endothelin receptor type A",TRUE
+"204463_s_at",0.881030044603,0.536948937288728,-0.627183680049672,-5.74988757057333,-0.68591265285056,"EDNRA","endothelin receptor type A",TRUE
+"204273_at",0.429170076412192,0.0187481569826717,2.5363993313719,-3.21433464886023,2.1024639459835,"EDNRB","endothelin receptor type B",TRUE
+"206701_x_at",0.51470556386048,0.0348314306590652,2.24829636066731,-3.73840581952589,2.70502064818857,"EDNRB","endothelin receptor type B",TRUE
+"204271_s_at",0.61299046462692,0.0845980629745076,1.80553332422663,-4.46555040568328,1.47766938033505,"EDNRB","endothelin receptor type B",TRUE
+"1568791_s_at",0.774230543658252,0.289306456812972,1.08564674196309,-5.38136433662482,0.68340677712927,"EDNRB-AS1","EDNRB antisense RNA 1",TRUE
+"208115_x_at",0.78187900363728,0.30348488733773,1.0534570102412,-5.41314377767655,0.447328745777273,"EDRF1","erythroid differentiation regulatory factor 1",TRUE
+"213410_at",0.837067957688307,0.419546382366006,0.822518169188863,-5.61543279268458,0.257365190442659,"EDRF1","erythroid differentiation regulatory factor 1",TRUE
+"215072_x_at",0.920734496427305,0.662794116330788,0.441970826678651,-5.84498670087202,0.3049712453851,"EDRF1","erythroid differentiation regulatory factor 1",TRUE
+"225885_at",0.731574335156004,0.21531002784281,-1.27559715482089,-5.17678875152985,-0.430748756454364,"EEA1","early endosome antigen 1",TRUE
+"204841_s_at",0.750020866111355,0.24287929695938,-1.19982732546785,-5.26183114360902,-0.424639119650969,"EEA1","early endosome antigen 1",TRUE
+"204840_s_at",0.815195559141692,0.366112654790158,-0.922680857892616,-5.53332189928064,-0.320252595604052,"EEA1","early endosome antigen 1",TRUE
+"210656_at",0.580137756009815,0.0626886978535902,-1.96002460255594,-4.22395937584222,-1.24647626838917,"EED","embryonic ectoderm development",TRUE
+"209572_s_at",0.844707676886687,0.441565434167324,0.783610349267247,-5.64495009399819,0.330216715744539,"EED","embryonic ectoderm development",TRUE
+"227708_at",0.739508010556618,0.227602568537948,1.24095183202468,-5.21623011850765,0.667116138595953,"EEF1A1","eukaryotic translation elongation factor 1 alpha 1",TRUE
+"1557120_at",0.756006545489432,0.250877447296365,1.17906900487415,-5.28434185929582,0.514749701287968,"EEF1A1","eukaryotic translation elongation factor 1 alpha 1",TRUE
+"204892_x_at",0.884221189678062,0.543118223830238,0.617626022476693,-5.75557604891382,0.140993776309683,"EEF1A1","eukaryotic translation elongation factor 1 alpha 1",TRUE
+"213614_x_at",0.918041148686074,0.651692111536384,0.457604775688571,-5.83820289233455,0.0974076012990288,"EEF1A1","eukaryotic translation elongation factor 1 alpha 1",TRUE
+"213583_x_at",0.92781038684564,0.683388804408784,0.413259440487094,-5.8568418055939,0.085139738376041,"EEF1A1","eukaryotic translation elongation factor 1 alpha 1",TRUE
+"213477_x_at",0.991541426661437,0.960312632208561,0.0503271540424999,-5.93844991162095,0.010282719019628,"EEF1A1","eukaryotic translation elongation factor 1 alpha 1",TRUE
+"204540_at",0.620912785033482,0.0907310973613795,-1.76857959322921,-4.52123014956071,-2.55341558219611,"EEF1A2","eukaryotic translation elongation factor 1 alpha 2",TRUE
+"227054_at",0.623667408398064,0.095083885353551,-1.7436348387029,-4.55833759783467,-0.601940646753377,"EEF1AKMT1","eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1",TRUE
+"214395_x_at",0.692529423238777,0.162035717964924,1.44650268507509,-4.96892115916688,0.477080584024456,"EEF1D","eukaryotic translation elongation factor 1 delta",TRUE
+"214394_x_at",0.744726124993666,0.236286765720682,1.21732707781151,-5.24258900776313,0.389758767635186,"EEF1D","eukaryotic translation elongation factor 1 delta",TRUE
+"213087_s_at",0.778665768282906,0.299124663891074,1.06323961488337,-5.4035764474782,0.472747497172612,"EEF1D","eukaryotic translation elongation factor 1 delta",TRUE
+"203113_s_at",0.837345289209351,0.420238523179359,0.821276033717015,-5.61639586771585,0.263753587604427,"EEF1D","eukaryotic translation elongation factor 1 delta",TRUE
+"213907_at",0.515810181619652,0.0361986953246384,2.22990949660395,-3.77061513928555,0.781618810654632,"EEF1E1","eukaryotic translation elongation factor 1 epsilon 1",TRUE
+"204905_s_at",0.632972753750874,0.104262507915508,1.69408102562824,-4.63088875653019,0.739490650757286,"EEF1E1","eukaryotic translation elongation factor 1 epsilon 1",TRUE
+"226544_x_at",0.948567563026335,0.765974707135453,0.30132732683418,-5.89555555274517,0.0865215594626747,"EEF1E1-BLOC1S5///BLOC1S5","EEF1E1-BLOC1S5 readthrough (NMD candidate)///biogenesis of lysosomal organelles complex 1 subunit 5",TRUE
+"226543_at",0.952239474918707,0.781310740616046,0.281009265444048,-5.90129497269595,0.0887653113271156,"EEF1E1-BLOC1S5///BLOC1S5","EEF1E1-BLOC1S5 readthrough (NMD candidate)///biogenesis of lysosomal organelles complex 1 subunit 5",TRUE
+"204102_s_at",0.918409982899324,0.653571969608961,-0.454949491221075,-5.83937135860008,-0.0964895293720254,"EEF2","eukaryotic translation elongation factor 2",TRUE
+"200094_s_at",0.978316880841318,0.895832543206814,-0.132438889083976,-5.93114397386436,-0.0350379733290431,"EEF2","eukaryotic translation elongation factor 2",TRUE
+"222013_x_at",0.96632730601064,0.843050983021628,0.200328582502302,-5.92015576841686,0.156576273730551,"EEF2KMT","eukaryotic elongation factor 2 lysine methyltransferase",TRUE
+"227540_at",0.841391443291102,0.431922042798279,-0.800498701554094,-5.63230285300178,-0.257302694229903,"EEFSEC","eukaryotic elongation factor, selenocysteine-tRNA specific",TRUE
+"233100_at",0.816265036022691,0.367278210355633,0.920397250387313,-5.5352910832269,0.590454938687728,"EEPD1","endonuclease/exonuclease/phosphatase family domain containing 1",TRUE
+"225631_at",0.929972194057784,0.690737206195033,0.403101082046799,-5.86084876479078,0.284468611610587,"EEPD1","endonuclease/exonuclease/phosphatase family domain containing 1",TRUE
+"1569640_s_at",0.932269331146744,0.701413090982585,0.388419035683881,-5.8664665476938,0.155438931721758,"EEPD1","endonuclease/exonuclease/phosphatase family domain containing 1",TRUE
+"225630_at",0.981488198026236,0.911997469666683,0.11178873848084,-5.93359862059506,0.0950630215085946,"EEPD1","endonuclease/exonuclease/phosphatase family domain containing 1",TRUE
+"220156_at",0.619415519928971,0.0895524766686932,1.77551058525418,-4.51085098010751,1.11496594750279,"EFCAB1","EF-hand calcium binding domain 1",TRUE
+"239500_at",0.657015752622694,0.125247907253333,1.59335331476102,-4.77344878630962,1.15487445378798,"EFCAB1","EF-hand calcium binding domain 1",TRUE
+"1568930_at",0.984810537070054,0.925572009566245,0.094486481177297,-5.93533606492339,0.080458448716104,"EFCAB1","EF-hand calcium binding domain 1",TRUE
+"243043_at",0.846529455216068,0.444816893563688,0.777967190640216,-5.64911947832415,0.53394834015688,"EFCAB10","EF-hand calcium binding domain 10",TRUE
+"214264_s_at",0.766989207029679,0.268111709129781,-1.13595968995784,-5.32999019848974,-0.471329540144104,"EFCAB11","EF-hand calcium binding domain 11",TRUE
+"210525_x_at",0.929126743655924,0.68843542924525,-0.40627834595572,-5.85960604188818,-0.311472120422746,"EFCAB11","EF-hand calcium binding domain 11",TRUE
+"232639_at",0.899915622178171,0.593968999680726,-0.540906501544765,-5.79817463796558,-0.371816190148483,"EFCAB12","EF-hand calcium binding domain 12",TRUE
+"231651_at",0.697699759202153,0.168475773099513,1.42365912165564,-4.99795599666755,0.829957846345745,"EFCAB13","EF-hand calcium binding domain 13",TRUE
+"1554772_at",0.812302873476553,0.356950042507245,0.940804252539544,-5.51753477348715,0.69065385621113,"EFCAB13","EF-hand calcium binding domain 13",TRUE
+"1553627_s_at",0.904807245926266,0.609324088897132,0.518390938351094,-5.80963625553123,0.554034384979543,"EFCAB13","EF-hand calcium binding domain 13",TRUE
+"1569876_at",0.930527241884777,0.692700306757244,-0.400394644154236,-5.86189975778764,-0.274635207128012,"EFCAB13","EF-hand calcium binding domain 13",TRUE
+"1553626_a_at",0.981508003489034,0.912080026287176,0.111683410671871,-5.93361007811015,0.0414337040139285,"EFCAB13","EF-hand calcium binding domain 13",TRUE
+"229524_at",0.677509122383198,0.145000872584914,1.51068120345604,-4.88534803574463,0.976390381290339,"EFCAB14","EF-hand calcium binding domain 14",TRUE
+"1559022_at",0.722990310174628,0.199714635386147,-1.3218177259652,-5.12273195580226,-0.76430677577839,"EFCAB14","EF-hand calcium binding domain 14",TRUE
+"201776_s_at",0.875315500639773,0.522563754117656,-0.64970244103169,-5.73615284541244,-0.210486046809487,"EFCAB14","EF-hand calcium binding domain 14",TRUE
+"201777_s_at",0.892643596418532,0.565028037313145,0.584137907208781,-5.77484192965449,0.17136845259718,"EFCAB14","EF-hand calcium binding domain 14",TRUE
+"1559023_a_at",0.896292432634083,0.580328133658139,0.561148155787008,-5.78746642209584,0.234590707166608,"EFCAB14","EF-hand calcium binding domain 14",TRUE
+"201778_s_at",0.931743994473996,0.698718527982228,0.392116423077785,-5.86507116023125,0.1193942733754,"EFCAB14","EF-hand calcium binding domain 14",TRUE
+"201775_s_at",0.957658694776965,0.81007328714659,-0.243219105389377,-5.91091200398788,-0.0752555464311264,"EFCAB14","EF-hand calcium binding domain 14",TRUE
+"207572_at",0.828381235576304,0.398181087929445,0.861517517120063,-5.58450391787804,0.595531876134375,"EFCAB2","EF-hand calcium binding domain 2",TRUE
+"223608_at",0.90344422113846,0.603949851711177,-0.526239904265984,-5.80569456670638,-0.257207621597379,"EFCAB2","EF-hand calcium binding domain 2",TRUE
+"211200_s_at",0.91876780831279,0.654919755265135,0.453047798112638,-5.8402041082575,0.235896482882849,"EFCAB2","EF-hand calcium binding domain 2",TRUE
+"233375_at",0.962741248200658,0.830509710177419,0.216589958323898,-5.91686055475204,0.196359253183993,"EFCAB2","EF-hand calcium binding domain 2",TRUE
+"1558301_a_at",0.730819267705703,0.213478089154601,1.28088946170413,-5.17068210188686,1.084024717806,"EFCAB5","EF-hand calcium binding domain 5",TRUE
+"1558300_at",0.921729477898827,0.666466499229551,0.436824067216592,-5.84716933791958,0.302097532995636,"EFCAB5","EF-hand calcium binding domain 5",TRUE
+"234732_s_at",0.180622515496298,0.00167490837414948,3.57533438078294,-1.11109270894654,1.75610643083903,"EFCAB6","EF-hand calcium binding domain 6",TRUE
+"233345_at",0.657015752622694,0.125944038728563,1.59026209574468,-4.7777170267657,0.564352908430885,"EFCAB6","EF-hand calcium binding domain 6",TRUE
+"233839_at",0.694819513561858,0.164286187723473,-1.4384383253151,-4.97921431692877,-0.708390857348452,"EFCAB6","EF-hand calcium binding domain 6",TRUE
+"1562815_at",0.837201352670384,0.419697365323737,0.822247101190993,-5.61564307834125,0.761706980331491,"EFCAB6","EF-hand calcium binding domain 6",TRUE
+"234853_s_at",0.853093296743962,0.459452127298453,0.752871686328248,-5.66731622427838,0.655126020398985,"EFCAB6","EF-hand calcium binding domain 6",TRUE
+"233600_at",0.971826767527606,0.865024627988496,0.171966832729925,-5.92529001789808,0.115119478744,"EFCAB6","EF-hand calcium binding domain 6",TRUE
+"220271_x_at",0.999359439711187,0.997952116615084,-0.00259575824821885,-5.93968019893732,-0.00104711668266955,"EFCAB6","EF-hand calcium binding domain 6",TRUE
+"226800_at",0.873694440227015,0.519367285424889,0.654752050055109,-5.733009106472,0.269469365840576,"EFCAB7","EF-hand calcium binding domain 7",TRUE
+"220006_at",0.937623890519979,0.723688703844021,-0.358057817949925,-5.87743154582125,-0.121235950183606,"EFCC1","EF-hand and coiled-coil domain containing 1",TRUE
+"233259_at",0.957571530817866,0.808763710284848,-0.244931450544169,-5.9105060424408,-0.183615703545136,"EFCC1","EF-hand and coiled-coil domain containing 1",TRUE
+"228421_s_at",0.193335085181883,0.00200142036054771,3.50142293360325,-1.2678498881207,2.03554601744255,"EFEMP1","EGF containing fibulin like extracellular matrix protein 1",TRUE
+"201842_s_at",0.396003975114129,0.0135876261054249,2.68132544169444,-2.93837329776773,3.94879821213907,"EFEMP1","EGF containing fibulin like extracellular matrix protein 1",TRUE
+"201843_s_at",0.439893508523601,0.0203232007778805,2.49961884143388,-3.28314110721239,3.79446246569539,"EFEMP1","EGF containing fibulin like extracellular matrix protein 1",TRUE
+"206580_s_at",0.623503825356688,0.0942994563338275,1.74805687316703,-4.55178780855372,0.701113807413049,"EFEMP2","EGF containing fibulin like extracellular matrix protein 2",TRUE
+"209356_x_at",0.697172073261335,0.167455958965962,1.42722920245806,-4.99344325240509,1.15404413764139,"EFEMP2","EGF containing fibulin like extracellular matrix protein 2",TRUE
+"239477_at",0.822469863206885,0.387465518197028,0.881584196746855,-5.56807035149919,0.83562102090505,"EFHB","EF-hand domain family member B",TRUE
+"1557840_at",0.943294768503521,0.744956686900334,-0.329387022425666,-5.88697689237708,-0.106488198184053,"EFHB","EF-hand domain family member B",TRUE
+"231026_at",0.909556758166751,0.624237911174196,0.496779297337303,-5.82019094917708,0.160323497958214,"EFHC1","EF-hand domain containing 1",TRUE
+"219833_s_at",0.974292018919448,0.874520938661885,0.159755709801118,-5.9272603505162,0.0752227922607229,"EFHC1","EF-hand domain containing 1",TRUE
+"225656_at",0.980009054680439,0.905781540291094,0.119722987048394,-5.93270452631659,0.0555244700583,"EFHC1","EF-hand domain containing 1",TRUE
+"220523_at",0.907255387493016,0.616386074509658,-0.508126858919917,-5.8147036816533,-0.411222368903919,"EFHC2","EF-hand domain containing 2",TRUE
+"220591_s_at",0.994174089523038,0.973483937098252,0.0336165416036293,-5.93913307939626,0.0172552239880419,"EFHC2","EF-hand domain containing 2",TRUE
+"209343_at",0.470885186348082,0.0255419904669185,-2.39427210301167,-3.47724859729248,-2.57261125500558,"EFHD1","EF-hand domain family member D1",TRUE
+"217992_s_at",0.622434989367596,0.0926444714728764,1.75749082007696,-4.53777358851823,0.906737616239894,"EFHD2","EF-hand domain family member D2",TRUE
+"222483_at",0.821424121108148,0.383319515704046,0.889445046855615,-5.56153704315058,0.320214794700217,"EFHD2","EF-hand domain family member D2",TRUE
+"218973_at",0.918041148686074,0.651778577281948,0.457482570344484,-5.83825681547696,0.140276851658488,"EFL1","elongation factor like GTPase 1",TRUE
+"202023_at",0.947778780715578,0.762347337552876,-0.306151744671087,-5.89413442228963,-0.28926362390591,"EFNA1","ephrin A1",TRUE
+"208256_at",0.641880516735663,0.112155490451632,1.65434833891058,-4.68792059671887,1.18683816278864,"EFNA2","ephrin A2",TRUE
+"238956_at",0.739340500562926,0.226803107099538,-1.24316094697699,-5.21374301923594,-1.33643794786535,"EFNA2","ephrin A2",TRUE
+"1553573_s_at",0.961539013416204,0.825584188244424,-0.222992656122957,-5.91549289403753,-0.112191961473163,"EFNA2","ephrin A2",TRUE
+"210132_at",0.816800680706682,0.368740580656229,-0.917538926180726,-5.5377495175081,-1.08899246463269,"EFNA3","ephrin A3",TRUE
+"205107_s_at",0.855075448726859,0.467333026471729,-0.739556531582886,-5.67674170589594,-0.509508819087698,"EFNA4","ephrin A4",TRUE
+"207301_at",0.637485146909712,0.108303635921138,1.67343219304664,-4.66065597453164,1.22228244779257,"EFNA5","ephrin A5",TRUE
+"214036_at",0.941106542715586,0.736030290440012,0.341384788363996,-5.88307827400954,0.157236608963963,"EFNA5","ephrin A5",TRUE
+"233814_at",0.947538317038068,0.760890165698334,0.308091873116235,-5.89355661120315,0.361723105021518,"EFNA5","ephrin A5",TRUE
+"227955_s_at",0.996898592071515,0.984169157910592,0.0200674870150923,-5.9394873403646,0.0166687885481416,"EFNA5","ephrin A5",TRUE
+"202711_at",0.571833476034523,0.0599065875021367,1.98293489096875,-4.18696819771939,0.799425202257137,"EFNB1","ephrin B1",TRUE
+"202668_at",0.291178024882244,0.00511259083469509,3.1069060658,-2.09036957868519,2.58200999598249,"EFNB2","ephrin B2",TRUE
+"202669_s_at",0.406049718268978,0.0152729285354811,2.62901753230717,-3.03883570853657,3.14369150267958,"EFNB2","ephrin B2",TRUE
+"210883_x_at",0.453888356579001,0.0219410503235171,2.46450667636509,-3.34833512053085,0.72299553308536,"EFNB3","ephrin B3",TRUE
+"205031_at",0.789824589976275,0.318674539641091,1.02013535702922,-5.44513464674856,1.17639959710471,"EFNB3","ephrin B3",TRUE
+"212150_at",0.830104575356196,0.401884205315912,0.854663966927296,-5.5900359726632,0.266078471349664,"EFR3A","EFR3 homolog A",TRUE
+"212149_at",0.929385267595748,0.689458287913949,0.404865916939259,-5.86015967079922,0.108666357815634,"EFR3A","EFR3 homolog A",TRUE
+"227283_at",0.280199223932988,0.00457046982659729,-3.15463046497829,-1.99240663003382,-1.72243180540454,"EFR3B","EFR3 homolog B",TRUE
+"215328_at",0.729083413548563,0.210672903263264,1.28906170345821,-5.161210081914,0.88969773067431,"EFR3B","EFR3 homolog B",TRUE
+"215334_at",0.971735822349954,0.864831429211836,-0.172215534878618,-5.92524838526559,-0.0818482691169438,"EFR3B","EFR3 homolog B",TRUE
+"210880_s_at",0.721094750464234,0.197281813081531,-1.32927896131378,-5.11385334981286,-1.79256244951962,"EFS","embryonal Fyn-associated substrate",TRUE
+"204400_at",0.921462951426584,0.665221183616356,-0.438567998004512,-5.84643258293656,-0.656159827635335,"EFS","embryonal Fyn-associated substrate",TRUE
+"222397_at",0.778974960380281,0.300031842671328,-1.06119594251765,-5.40558169943067,-0.637381265914547,"EFTUD2","elongation factor Tu GTP binding domain containing 2",TRUE
+"222398_s_at",0.97304633500821,0.869379304346613,0.166364030061252,-5.92621202309979,0.0448687792133153,"EFTUD2","elongation factor Tu GTP binding domain containing 2",TRUE
+"206254_at",0.862800800218883,0.486838006170864,0.707161260699882,-5.69900617394315,0.788947475267774,"EGF","epidermal growth factor",TRUE
+"1558411_at",0.91608830456523,0.646033307703946,-0.465618090111916,-5.8346362194298,-0.526878239753833,"EGFEM1P","EGF like and EMI domain containing 1, pseudogene",TRUE
+"219454_at",0.739367922105944,0.227169568397965,1.24214758608328,-5.21488436905439,0.794600312995928,"EGFL6","EGF like domain multiple 6",TRUE
+"218825_at",0.820288124919738,0.378730204780579,-0.898211600175122,-5.55418765445948,-0.706687587402967,"EGFL7","EGF like domain multiple 7",TRUE
+"209490_s_at",0.861981304384929,0.484743286070844,0.710603610864476,-5.69668538276742,0.305557000735849,"EGFL8///PPT2","EGF like domain multiple 8///palmitoyl-protein thioesterase 2",TRUE
+"226911_at",0.594005743610726,0.0708688409841481,1.89750654354438,-4.32339778099766,2.11916492133612,"EGFLAM","EGF like, fibronectin type III and laminin G domains",TRUE
+"240225_at",0.936062094643129,0.714249191155312,0.37088017601818,-5.87290809299715,0.239897880665669,"EGFLAM-AS2","EGFLAM antisense RNA 2",TRUE
+"1556740_at",0.959172065635938,0.814932235299245,0.236872205146347,-5.91239201811034,0.0888857399618144,"EGFLAM-AS2","EGFLAM antisense RNA 2",TRUE
+"1570163_at",0.989143455305063,0.947134557098863,0.0670610682134898,-5.93749330419872,0.0520529863278858,"EGFLAM-AS4","EGFLAM antisense RNA 4",TRUE
+"211607_x_at",0.196858188611682,0.00214950779334567,3.47172488792557,-1.33064055911793,4.32869230555337,"EGFR","epidermal growth factor receptor",TRUE
+"210984_x_at",0.268560525805689,0.00415098854597304,3.19547712697235,-1.90818178440193,3.85379786307945,"EGFR","epidermal growth factor receptor",TRUE
+"201984_s_at",0.35702404570702,0.00965123986383129,2.83245153274186,-2.64310036818918,3.04709364748001,"EGFR","epidermal growth factor receptor",TRUE
+"224999_at",0.391326002716224,0.013183767663526,2.69476720475817,-2.91240696730313,3.3768094194169,"EGFR","epidermal growth factor receptor",TRUE
+"201983_s_at",0.39149295959037,0.0132249735581725,2.69337806061019,-2.91509325978876,4.2620861502062,"EGFR","epidermal growth factor receptor",TRUE
+"1565483_at",0.630132423960255,0.101268303367547,1.70982300864188,-4.60801063488177,1.12891218358902,"EGFR","epidermal growth factor receptor",TRUE
+"211551_at",0.77204612088057,0.282324900633081,1.10191508427963,-5.36497886737636,0.338458721740586,"EGFR","epidermal growth factor receptor",TRUE
+"211550_at",0.879126527961063,0.532803770292056,0.633638658484776,-5.74599815730073,0.284313103360453,"EGFR","epidermal growth factor receptor",TRUE
+"1565484_x_at",0.972601546178428,0.867505433973176,-0.168774305572791,-5.92581911715795,-0.0990662079890976,"EGFR","epidermal growth factor receptor",TRUE
+"223046_at",0.831370271469237,0.405596170483227,-0.847834564465034,-5.59550757543208,-0.410337582667525,"EGLN1","egl-9 family hypoxia inducible factor 1",TRUE
+"223045_at",0.943464796017993,0.746830226464455,0.326875148920361,-5.88777564386324,0.35656264032075,"EGLN1","egl-9 family hypoxia inducible factor 1",TRUE
+"224314_s_at",0.94943075115007,0.771556587141321,-0.293917591597886,-5.8976946604016,-0.147992059691216,"EGLN1","egl-9 family hypoxia inducible factor 1",TRUE
+"221497_x_at",0.97689149311934,0.89000309996625,-0.139899818716228,-5.93015519471513,-0.063529756341774,"EGLN1","egl-9 family hypoxia inducible factor 1",TRUE
+"227147_s_at",0.522403182336918,0.0382317983852112,-2.20370501592434,-3.81624229264732,-1.34925227359213,"EGLN2","egl-9 family hypoxia inducible factor 2",TRUE
+"222847_s_at",0.554642754132296,0.0512180626758915,-2.06112805223472,-4.0585598739824,-2.96737566937995,"EGLN3","egl-9 family hypoxia inducible factor 3",TRUE
+"219232_s_at",0.729789891627758,0.212137829652543,-1.2847835777849,-5.16617503039947,-1.18405787473481,"EGLN3","egl-9 family hypoxia inducible factor 3",TRUE
+"222314_x_at",0.683019114815084,0.151750339266166,1.48455488834057,-4.91972269263037,1.07670762416103,"EGOT","eosinophil granule ontogeny transcript (non-protein coding)",TRUE
+"240475_at",0.752312913127213,0.245652353691086,1.1925729526827,-5.26973681882537,0.384271215783978,"EGOT","eosinophil granule ontogeny transcript (non-protein coding)",TRUE
+"227404_s_at",0.731258945393095,0.214288629594662,1.27854358330207,-5.17339160747495,1.50301679696464,"EGR1","early growth response 1",TRUE
+"201694_s_at",0.755868740464627,0.250433826307834,1.18020730904116,-5.28311634076638,1.10610300202853,"EGR1","early growth response 1",TRUE
+"201693_s_at",0.78578093265889,0.311274666810477,1.03622525020323,-5.42980299721481,0.460969044006651,"EGR1","early growth response 1",TRUE
+"205249_at",0.887780176248324,0.552980745969183,0.602465733683869,-5.76442628250084,0.62776931697475,"EGR2","early growth response 2",TRUE
+"206115_at",0.755049574909504,0.248726757939379,-1.18460163314066,-5.27837564968983,-1.34225334073292,"EGR3","early growth response 3",TRUE
+"207768_at",0.707829100323006,0.179477668871313,-1.38620367073535,-5.04473997457692,-1.14117766832022,"EGR4","early growth response 4",TRUE
+"207767_s_at",0.863865128741987,0.489960658817777,0.702045497439904,-5.70243531913972,0.174750417353872,"EGR4","early growth response 4",TRUE
+"231575_at",0.968066640321622,0.850194851273645,0.191090569085454,-5.92191370966301,0.159086707901652,"EGR4","early growth response 4",TRUE
+"212650_at",0.468732760220321,0.0247901587499383,2.40814296070699,-3.45195049972136,0.903776543420101,"EHBP1","EH domain binding protein 1",TRUE
+"212653_s_at",0.570858914783499,0.0590853333106506,1.98987791465439,-4.17570058360668,0.760993069949258,"EHBP1","EH domain binding protein 1",TRUE
+"91703_at",0.595997098747707,0.0726010202325996,1.88508699804911,-4.34288481249531,0.991305038052257,"EHBP1L1","EH domain binding protein 1 like 1",TRUE
+"221755_at",0.662015916975184,0.129895405543597,1.57298023759008,-4.80145982555154,1.69994024869318,"EHBP1L1","EH domain binding protein 1 like 1",TRUE
+"1557228_at",0.748228297946268,0.240719446929581,1.2055207623743,-5.25559736522612,0.501540292363511,"EHBP1L1","EH domain binding protein 1 like 1",TRUE
+"1557749_at",0.822850703882235,0.388525836068408,0.879582646018161,-5.56972528962149,0.479066008428005,"EHBP1L1","EH domain binding protein 1 like 1",TRUE
+"208112_x_at",0.896139457361073,0.578646486490893,-0.563659863444488,-5.78611105853226,-0.251107423508818,"EHD1","EH domain containing 1",TRUE
+"209037_s_at",0.897949253801113,0.58604127096786,-0.552642069191082,-5.79201283169186,-0.304775542246533,"EHD1","EH domain containing 1",TRUE
+"222221_x_at",0.9116561917482,0.630780127542715,-0.48737471356018,-5.82464694420616,-0.275234889356904,"EHD1","EH domain containing 1",TRUE
+"209039_x_at",0.949038895598021,0.770252230500144,-0.295647556792489,-5.89719996396898,-0.126849476601878,"EHD1","EH domain containing 1",TRUE
+"209038_s_at",0.958792863216689,0.813480226484352,-0.238767807595039,-5.91195406422364,-0.140377710069151,"EHD1","EH domain containing 1",TRUE
+"221870_at",0.571677937624457,0.0594755179663047,1.98656863207396,-4.18107442343208,3.30096064691592,"EHD2","EH domain containing 2",TRUE
+"45297_at",0.61400463972392,0.0849106370544593,1.80359492989616,-4.46849185585279,2.08350427575059,"EHD2","EH domain containing 2",TRUE
+"205341_at",0.66246262208156,0.130141948308697,1.57191648688511,-4.80291462983486,1.48815744509733,"EHD2","EH domain containing 2",TRUE
+"218935_at",0.620912785033482,0.0909629467078924,1.76722529912086,-4.52325473018826,0.915666387727757,"EHD3","EH domain containing 3",TRUE
+"230740_at",0.722442821599878,0.19898926837926,1.3240348933202,-5.12009800197885,0.558582670231655,"EHD3","EH domain containing 3",TRUE
+"241267_at",0.906507435035949,0.61455035606345,-0.51078958256208,-5.81339857328035,-0.358268653932015,"EHD3","EH domain containing 3",TRUE
+"239472_at",0.748184017928985,0.240400311010736,-1.20636527090844,-5.25467052560228,-1.27141337646043,"EHD4","EH domain containing 4",TRUE
+"209536_s_at",0.769258076576208,0.275661871332962,1.11771537006365,-5.34885766349016,0.419489394170286,"EHD4","EH domain containing 4",TRUE
+"233660_at",0.819203514175924,0.376040572838634,0.903381864472223,-5.54982194455641,0.25865501881761,"EHD4","EH domain containing 4",TRUE
+"1556607_at",0.833766866664969,0.411462233129478,0.837122820030254,-5.6040071204849,0.513377805739424,"EHD4","EH domain containing 4",TRUE
+"237097_at",0.894136768148992,0.570375954314167,0.576066636845035,-5.77933007577681,0.261212947703567,"EHD4","EH domain containing 4",TRUE
+"1556608_a_at",0.912722788750542,0.634152811835531,0.48254381362906,-5.82690351931043,0.229265167593625,"EHD4","EH domain containing 4",TRUE
+"229074_at",0.936143408699214,0.714959596530808,0.369913002169432,-5.87325476859919,0.12968983087065,"EHD4","EH domain containing 4",TRUE
+"224189_x_at",0.518537987260825,0.0371583325850555,2.21737842251145,-3.79247506048193,2.77547479692325,"EHF","ETS homologous factor",TRUE
+"219850_s_at",0.519956259865057,0.0375205548543654,2.21272489184508,-3.80057391414179,3.02125248057299,"EHF","ETS homologous factor",TRUE
+"222932_at",0.56023218711292,0.0541839562039894,2.03319114021215,-4.10481525872409,2.65880328780541,"EHF","ETS homologous factor",TRUE
+"232361_s_at",0.567292616148537,0.0574497351864214,2.00396440685434,-4.15275880689962,3.30409903953768,"EHF","ETS homologous factor",TRUE
+"232360_at",0.65284137151906,0.121935053712713,1.60826352620902,-4.75277082713416,2.14236755280653,"EHF","ETS homologous factor",TRUE
+"225645_at",0.677013732819214,0.144422448994785,1.51296613212775,-4.88231889838001,2.78470486902633,"EHF","ETS homologous factor",TRUE
+"205222_at",0.535932732913193,0.0430216509328944,2.1466460851448,-3.9144425136372,1.55631149510997,"EHHADH","enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase",TRUE
+"225461_at",0.632949074657601,0.10422442709835,-1.69427880984714,-4.63060230022242,-0.649264070546433,"EHMT1","euchromatic histone lysine methyltransferase 1",TRUE
+"219339_s_at",0.653375957820821,0.122742827739713,-1.60459709424703,-4.75786942067146,-0.492657794130592,"EHMT1","euchromatic histone lysine methyltransferase 1",TRUE
+"222873_s_at",0.830326542770255,0.402729118742456,-0.85310592761951,-5.5912878501308,-0.309591945362086,"EHMT1","euchromatic histone lysine methyltransferase 1",TRUE
+"1559311_at",0.760563533925384,0.259676015257931,1.15679579774222,-5.30811324462493,0.62143723355968,"EHMT1-IT1","EHMT1 intronic transcript 1",TRUE
+"207484_s_at",0.713330901550199,0.188165572602988,1.35789557446614,-5.07941185841236,0.422018534892564,"EHMT2","euchromatic histone lysine methyltransferase 2",TRUE
+"229079_at",0.722160153958635,0.198398568944771,1.32584510193024,-5.11794474948135,0.813508592666193,"EHMT2","euchromatic histone lysine methyltransferase 2",TRUE
+"202326_at",0.974982245454858,0.878588029830044,-0.154533622282935,-5.92805879045174,-0.0602824860658977,"EHMT2","euchromatic histone lysine methyltransferase 2",TRUE
+"208289_s_at",0.885190678056007,0.54626783481504,-0.612768858454159,-5.75843464658692,-0.190500570953171,"EI24","EI24, autophagy associated transmembrane protein",TRUE
+"216396_s_at",0.955730092376044,0.79745930961025,-0.259744345052384,-5.90687605228348,-0.115960884024,"EI24","EI24, autophagy associated transmembrane protein",TRUE
+"208670_s_at",0.882023958362664,0.539377614043999,-0.623414119111166,-5.75214116694884,-0.634211299095128,"EID1","EP300 interacting inhibitor of differentiation 1",TRUE
+"211698_at",0.904381089098038,0.607823109897582,-0.520579750351348,-5.80854285291359,-0.587748240361334,"EID1","EP300 interacting inhibitor of differentiation 1",TRUE
+"208669_s_at",0.948429371744093,0.765697463807447,-0.301695802697946,-5.89544779984564,-0.422512205953625,"EID1","EP300 interacting inhibitor of differentiation 1",TRUE
+"225936_at",0.870980161749509,0.511125631009817,-0.667851606102799,-5.72474491585464,-0.229169273015039,"EID2","EP300 interacting inhibitor of differentiation 2",TRUE
+"242470_at",0.597654932724127,0.0738504932054584,-1.87628832188666,-4.35663609443202,-1.08745617942945,"EID2B","EP300 interacting inhibitor of differentiation 2B",TRUE
+"231292_at",0.895457620469779,0.574512356428816,-0.569850252056615,-5.78274555544072,-0.687955344026718,"EID3","EP300 interacting inhibitor of differentiation 3",TRUE
+"212225_at",0.910263605770897,0.626994856550291,0.492810636667489,-5.82208149011388,0.199651539147982,"EIF1","eukaryotic translation initiation factor 1",TRUE
+"217672_x_at",0.95396321837061,0.78768485584529,0.272600377213553,-5.90355402268509,0.0674574563239769,"EIF1","eukaryotic translation initiation factor 1",TRUE
+"212227_x_at",0.965707350334601,0.839720625133229,0.204641250648887,-5.9193067905289,0.0560583179538234,"EIF1","eukaryotic translation initiation factor 1",TRUE
+"211956_s_at",0.980832655742,0.910148950549835,-0.114147467152219,-5.93333921342345,-0.0258478703487466,"EIF1","eukaryotic translation initiation factor 1",TRUE
+"212130_x_at",0.982618070910039,0.915671458061609,0.107102607472816,-5.93409793889597,0.0287126623389398,"EIF1","eukaryotic translation initiation factor 1",TRUE
+"202021_x_at",0.994471114396429,0.974536220178258,0.0322819834221192,-5.93917591212351,0.00882680107896405,"EIF1","eukaryotic translation initiation factor 1",TRUE
+"228967_at",0.99783553534859,0.989766257966513,0.0129719631203173,-5.93960152207853,0.00666840361027177,"EIF1","eukaryotic translation initiation factor 1",TRUE
+"223682_s_at",0.499983604958508,0.0317213441086296,-2.29270521593173,-3.65996487324285,-0.693179312597989,"EIF1AD","eukaryotic translation initiation factor 1A domain containing",TRUE
+"239377_at",0.54295328972902,0.0459479142277815,-2.1145529019342,-3.96896551212593,-0.860476232970475,"EIF1AD","eukaryotic translation initiation factor 1A domain containing",TRUE
+"201018_at",0.702888118552354,0.174774834366936,-1.40198353108545,-5.02515542855693,-0.65677317557971,"EIF1AX","eukaryotic translation initiation factor 1A, X-linked",TRUE
+"201017_at",0.834454640870101,0.412922949186873,-0.834470583643455,-5.60609602168187,-0.355020085805823,"EIF1AX","eukaryotic translation initiation factor 1A, X-linked",TRUE
+"201016_at",0.857436624285661,0.473013323487958,-0.730041792849089,-5.68337922316402,-0.265673757730356,"EIF1AX","eukaryotic translation initiation factor 1A, X-linked",TRUE
+"201019_s_at",0.888312537451395,0.554227183219799,-0.600559924472095,-5.76552382995817,-0.177369210599025,"EIF1AX","eukaryotic translation initiation factor 1A, X-linked",TRUE
+"204409_s_at",0.940031619815611,0.730536097113276,-0.348794775983008,-5.88060154763971,-0.30979141864852,"EIF1AY","eukaryotic translation initiation factor 1A, Y-linked",TRUE
+"204410_at",0.997171203405,0.985759363333771,-0.0180514696957148,-5.93952476976717,-0.0163169427788441,"EIF1AY","eukaryotic translation initiation factor 1A, Y-linked",TRUE
+"237988_at",0.622917527985155,0.0935974342491445,-1.75204115429529,-4.54587590943984,-1.06494896113115,"EIF1B","eukaryotic translation initiation factor 1B",TRUE
+"201738_at",0.989638901366417,0.950035244920332,0.0633761743793036,-5.93772736179785,0.0185568404032708,"EIF1B","eukaryotic translation initiation factor 1B",TRUE
+"1557212_at",0.748632141741128,0.24152407704853,1.20339525688373,-5.25792759222869,0.550103620778562,"EIF1B-AS1","EIF1B antisense RNA 1",TRUE
+"1556248_at",0.80852335663303,0.351506176262773,0.951720643361305,-5.50788962247841,0.535150263727063,"EIF1B-AS1","EIF1B antisense RNA 1",TRUE
+"1556249_a_at",0.847515494238763,0.4462387695512,0.775507324195976,-5.65092802901569,0.225361172015127,"EIF1B-AS1","EIF1B antisense RNA 1",TRUE
+"223015_at",0.645213368083975,0.116439328813618,1.6337622586853,-4.7170633065766,0.517461712056143,"EIF2A","eukaryotic translation initiation factor 2A",TRUE
+"217735_s_at",0.782921408555092,0.305378486711776,1.04923962871989,-5.41724386154413,0.36426513668278,"EIF2AK1","eukaryotic translation initiation factor 2 alpha kinase 1",TRUE
+"217736_s_at",0.944850801239076,0.751970436132835,0.319994565176998,-5.88993260439469,0.107555442359395,"EIF2AK1","eukaryotic translation initiation factor 2 alpha kinase 1",TRUE
+"242898_at",0.194325783329824,0.00203956748402185,3.4935720513614,-1.28446041019205,1.32906745252653,"EIF2AK2","eukaryotic translation initiation factor 2 alpha kinase 2",TRUE
+"213294_at",0.245363000968222,0.00332087097789638,3.28968109215173,-1.71269425549026,1.29397022500408,"EIF2AK2","eukaryotic translation initiation factor 2 alpha kinase 2",TRUE
+"204211_x_at",0.354266150238033,0.00946403503768495,2.84102607298495,-2.62613733612986,0.836850482933666,"EIF2AK2","eukaryotic translation initiation factor 2 alpha kinase 2",TRUE
+"218696_at",0.634797731123106,0.10574737512701,-1.68641628988696,-4.64197037734542,-0.529039333907642,"EIF2AK3","eukaryotic translation initiation factor 2 alpha kinase 3",TRUE
+"241463_at",0.8920930097751,0.562749761738084,0.587588265757907,-5.77290487196746,0.279213687204491,"EIF2AK3","eukaryotic translation initiation factor 2 alpha kinase 3",TRUE
+"237145_at",0.937113154905832,0.719301805585136,-0.364009113306089,-5.87535159489646,-0.248310203044557,"EIF2AK4","eukaryotic translation initiation factor 2 alpha kinase 4",TRUE
+"225164_s_at",0.981496397992228,0.912042176431516,0.111731700307191,-5.9336048265229,0.053593515747151,"EIF2AK4","eukaryotic translation initiation factor 2 alpha kinase 4",TRUE
+"201632_at",0.803583569469174,0.342006137178836,-0.971048585612678,-5.49056281789174,-0.29340573371644,"EIF2B1","eukaryotic translation initiation factor 2B subunit alpha",TRUE
+"202461_at",0.723649742218726,0.200323283717469,-1.31996216759991,-5.12493346362221,-0.562932217590701,"EIF2B2","eukaryotic translation initiation factor 2B subunit beta",TRUE
+"218488_at",0.978926990556789,0.897067745914345,-0.130858992771276,-5.93134641489265,-0.0381516719445045,"EIF2B3","eukaryotic translation initiation factor 2B subunit gamma",TRUE
+"209429_x_at",0.90344422113846,0.603938721507355,-0.526256194311894,-5.80568632599237,-0.157322738019861,"EIF2B4","eukaryotic translation initiation factor 2B subunit delta",TRUE
+"215482_s_at",0.930578279104258,0.692844576086548,-0.400195866794505,-5.8619766743386,-0.129860341948278,"EIF2B4","eukaryotic translation initiation factor 2B subunit delta",TRUE
+"212351_at",0.75017710842651,0.243088922270804,-1.19927677524036,-5.26243258464446,-0.372846528055227,"EIF2B5","eukaryotic translation initiation factor 2B subunit epsilon",TRUE
+"1558050_at",0.93647371549118,0.716567249406292,-0.367725604928959,-5.8740355281468,-0.192293201114484,"EIF2B5","eukaryotic translation initiation factor 2B subunit epsilon",TRUE
+"218253_s_at",0.928246500493356,0.684782011777707,-0.411330116105769,-5.85761037452103,-0.156577672632912,"EIF2D","eukaryotic translation initiation factor 2D",TRUE
+"201142_at",0.562894650172193,0.0554718930528215,-2.02148240353911,-4.12407763881133,-0.704047519073896,"EIF2S1","eukaryotic translation initiation factor 2 subunit alpha",TRUE
+"201144_s_at",0.757950630724418,0.25436714250807,-1.17016657406776,-5.2938907137887,-0.31037672554851,"EIF2S1","eukaryotic translation initiation factor 2 subunit alpha",TRUE
+"201143_s_at",0.778580821633075,0.298915226829444,-1.06371205787738,-5.40311239430833,-0.370931828907668,"EIF2S1","eukaryotic translation initiation factor 2 subunit alpha",TRUE
+"208726_s_at",0.848065008592295,0.447679054009892,0.77302046911955,-5.65275092887287,0.263389332487215,"EIF2S2","eukaryotic translation initiation factor 2 subunit beta",TRUE
+"208725_at",0.955743694751825,0.798116006458048,0.258882238241754,-5.90709312014459,0.228830124688488,"EIF2S2","eukaryotic translation initiation factor 2 subunit beta",TRUE
+"224936_at",0.783996924089035,0.30708876316947,-1.045446446111,-5.42091891837538,-0.347191936433807,"EIF2S3","eukaryotic translation initiation factor 2 subunit gamma",TRUE
+"224935_at",0.852994610926182,0.459192256756259,-0.753313062394358,-5.66700105713495,-0.257172573750667,"EIF2S3","eukaryotic translation initiation factor 2 subunit gamma",TRUE
+"205321_at",0.857886999805586,0.473479468778904,-0.729263977548471,-5.6839182217515,-0.651858395755374,"EIF2S3","eukaryotic translation initiation factor 2 subunit gamma",TRUE
+"200596_s_at",0.701743735478035,0.173276969442739,1.40708049573235,-5.01879043653149,0.49802889498295,"EIF3A","eukaryotic translation initiation factor 3 subunit A",TRUE
+"200595_s_at",0.767030236469048,0.26875460619089,1.13439163312169,-5.3316224099845,0.326174993444726,"EIF3A","eukaryotic translation initiation factor 3 subunit A",TRUE
+"200597_at",0.864079461576774,0.490890483558021,0.700525817291754,-5.70344940239844,0.267598418307401,"EIF3A","eukaryotic translation initiation factor 3 subunit A",TRUE
+"242550_at",0.528176582660474,0.0407546240489206,2.17289376562487,-3.8694677215155,0.808012073580052,"EIF3B","eukaryotic translation initiation factor 3 subunit B",TRUE
+"236274_at",0.724590981430178,0.201865956012007,1.31527871220776,-5.13047849247742,0.656138550990274,"EIF3B","eukaryotic translation initiation factor 3 subunit B",TRUE
+"208688_x_at",0.803672662427564,0.342224177899196,0.970600903084164,-5.49096774901387,0.302077888804584,"EIF3B","eukaryotic translation initiation factor 3 subunit B",TRUE
+"203462_x_at",0.813442508625161,0.363961041059664,0.926909165581996,-5.52966391674555,0.291142886573347,"EIF3B","eukaryotic translation initiation factor 3 subunit B",TRUE
+"237457_at",0.869190293677726,0.506125493915277,-0.675856450919624,-5.71961767901856,-0.453725335547716,"EIF3B","eukaryotic translation initiation factor 3 subunit B",TRUE
+"211501_s_at",0.872668627020452,0.516548722974759,0.659218905093643,-5.73020871099217,0.251516651335793,"EIF3B","eukaryotic translation initiation factor 3 subunit B",TRUE
+"236700_at",0.999328749224215,0.997815039689739,-0.00276950812244997,-5.93967974489023,-0.00301984086891594,"EIF3C","eukaryotic translation initiation factor 3 subunit C",TRUE
+"200647_x_at",0.498206796273596,0.031050064601626,-2.30281125897968,-3.64198840547575,-0.870868979384202,"EIF3CL///EIF3C","eukaryotic translation initiation factor 3 subunit C-like///eukaryotic translation initiation factor 3 subunit C",TRUE
+"210949_s_at",0.528328646587879,0.0409831214643789,-2.17018917688293,-3.87411769708999,-0.686086982965953,"EIF3CL///EIF3C","eukaryotic translation initiation factor 3 subunit C-like///eukaryotic translation initiation factor 3 subunit C",TRUE
+"215230_x_at",0.677013732819214,0.144339923819905,-1.5132927393249,-4.88188561539645,-0.739257492712438,"EIF3CL///EIF3C","eukaryotic translation initiation factor 3 subunit C-like///eukaryotic translation initiation factor 3 subunit C",TRUE
+"200005_at",0.760905446901853,0.259950987199012,1.15610880009545,-5.30884013285025,0.356645274543348,"EIF3D","eukaryotic translation initiation factor 3 subunit D",TRUE
+"208697_s_at",0.964970817135779,0.837486007744969,0.20753720495962,-5.9187265955849,0.0659315268177654,"EIF3E","eukaryotic translation initiation factor 3 subunit E",TRUE
+"235429_at",0.986361618040699,0.935795870235361,-0.0814748121203401,-5.9364508021905,-0.0325581985668073,"EIF3E","eukaryotic translation initiation factor 3 subunit E",TRUE
+"230479_at",0.682539393883246,0.150394197865193,-1.48972714096212,-4.91295575616513,-0.874157816651216,"EIF3F","eukaryotic translation initiation factor 3 subunit F",TRUE
+"200865_at",0.861741789060045,0.483978145709498,0.711863147795413,-5.69583353602403,0.634540179872933,"EIF3F","eukaryotic translation initiation factor 3 subunit F",TRUE
+"200023_s_at",0.928575610946638,0.685880677605487,-0.409809794661219,-5.85821351965283,-0.135688152687642,"EIF3F","eukaryotic translation initiation factor 3 subunit F",TRUE
+"208887_at",0.671298718565642,0.137387937313958,1.54137321427911,-4.84435539791114,0.654001399927456,"EIF3G","eukaryotic translation initiation factor 3 subunit G",TRUE
+"201592_at",0.949740807420078,0.772464672415733,0.292713740993071,-5.89803721157633,0.110214868571664,"EIF3H","eukaryotic translation initiation factor 3 subunit H",TRUE
+"230570_at",0.962771126516533,0.83059810272809,-0.216475141988148,-5.91688471835251,-0.177846759710747,"EIF3H","eukaryotic translation initiation factor 3 subunit H",TRUE
+"208756_at",0.991249206045988,0.95892179987291,0.0520924944875243,-5.93836185903796,0.0147574810971669,"EIF3I","eukaryotic translation initiation factor 3 subunit I",TRUE
+"208264_s_at",0.896139457361073,0.578671826212533,-0.563621988883027,-5.78613153993533,-0.198305934226411,"EIF3J","eukaryotic translation initiation factor 3 subunit J",TRUE
+"208985_s_at",0.991523919855535,0.960223137310118,0.0504407421525738,-5.93844433736141,0.0162154751554446,"EIF3J","eukaryotic translation initiation factor 3 subunit J",TRUE
+"235124_at",0.90344422113846,0.604455278502716,-0.525500318868295,-5.80606844226508,-0.205545487828745,"EIF3J-AS1","EIF3J antisense RNA 1 (head to head)",TRUE
+"212716_s_at",0.830635993561085,0.403450055519131,-0.851778159034572,-5.59235302596168,-0.204217677374638,"EIF3K","eukaryotic translation initiation factor 3 subunit K",TRUE
+"210501_x_at",0.888906097697714,0.556218663272688,-0.59751958562782,-5.76726779514492,-0.154563296803168,"EIF3K","eukaryotic translation initiation factor 3 subunit K",TRUE
+"221494_x_at",0.971171671890693,0.861682834478087,-0.176270257258302,-5.92456116453262,-0.0477575263946601,"EIF3K","eukaryotic translation initiation factor 3 subunit K",TRUE
+"236605_at",0.999886947266554,0.999701921226451,0.000377824026444446,-5.93968341122036,0.000134554028481837,"EIF3K","eukaryotic translation initiation factor 3 subunit K",TRUE
+"217719_at",0.860026478479837,0.47855856416926,0.720817900929459,-5.68973589588902,0.1638573312391,"EIF3L","eukaryotic translation initiation factor 3 subunit L",TRUE
+"202232_s_at",0.726636642789909,0.205820671832776,-1.30339846436452,-5.14446948404264,-0.360762049910026,"EIF3M","eukaryotic translation initiation factor 3 subunit M",TRUE
+"202231_at",0.737161440695888,0.223346075336387,-1.25278254901413,-5.20286635084813,-0.338501007821476,"EIF3M","eukaryotic translation initiation factor 3 subunit M",TRUE
+"240513_at",0.744307803443383,0.235124256984418,1.22045103856705,-5.23912861955016,0.852213722500984,"EIF3M","eukaryotic translation initiation factor 3 subunit M",TRUE
+"239848_at",0.850644926483418,0.45345947923705,-0.763088258952785,-5.65997623536541,-0.564462930061613,"EIF3M","eukaryotic translation initiation factor 3 subunit M",TRUE
+"215190_at",0.852855949428146,0.458974548806105,-0.753682942730216,-5.66673680727669,-0.309611822586781,"EIF3M","eukaryotic translation initiation factor 3 subunit M",TRUE
+"1556350_a_at",0.846506765330126,0.444719896247692,-0.778135171888397,-5.64899577757605,-0.747775128751218,"EIF4A2","eukaryotic translation initiation factor 4A2",TRUE
+"201303_at",0.703212178768756,0.17504715250148,-1.40106062908569,-5.02630589369124,-0.375653295454745,"EIF4A3","eukaryotic translation initiation factor 4A3",TRUE
+"219599_at",0.879105775060965,0.53270513824499,-0.633792580806416,-5.74590494448234,-0.228112716384675,"EIF4B","eukaryotic translation initiation factor 4B",TRUE
+"211937_at",0.941397317345279,0.737777720255924,-0.339032138437312,-5.88385362937918,-0.15502673033499,"EIF4B","eukaryotic translation initiation factor 4B",TRUE
+"211938_at",0.948109877411639,0.764380195456942,-0.303447128557965,-5.89493387749136,-0.10851785671524,"EIF4B","eukaryotic translation initiation factor 4B",TRUE
+"242674_at",0.59507179340408,0.0719875550571907,-1.88945552694744,-4.33604054212926,-0.479399744128381,"EIF4E","eukaryotic translation initiation factor 4E",TRUE
+"201437_s_at",0.693742297578797,0.162852883757012,-1.44356406738473,-4.97267737577101,-0.378748378866405,"EIF4E","eukaryotic translation initiation factor 4E",TRUE
+"201435_s_at",0.710672261019989,0.183814781184311,-1.37193952815631,-5.06228514521747,-0.375054867440587,"EIF4E","eukaryotic translation initiation factor 4E",TRUE
+"201436_at",0.854184492233394,0.464555570385043,-0.744233813042194,-5.67344893022545,-0.343443669380651,"EIF4E","eukaryotic translation initiation factor 4E",TRUE
+"237718_at",0.945498722604777,0.753778640809177,-0.317577897412825,-5.89067941251408,-0.249247441716658,"EIF4E","eukaryotic translation initiation factor 4E",TRUE
+"226734_at",0.861659105448003,0.482976440728698,-0.71351385235279,-5.69471496113061,-0.187341069574176,"EIF4E2","eukaryotic translation initiation factor 4E family member 2",TRUE
+"213571_s_at",0.873081085324568,0.517467315791439,-0.657761642844591,-5.7311243161237,-0.236405229863859,"EIF4E2","eukaryotic translation initiation factor 4E family member 2",TRUE
+"209393_s_at",0.879260022051756,0.53310415603138,-0.633169980079347,-5.74628184708997,-0.220068696477163,"EIF4E2","eukaryotic translation initiation factor 4E family member 2",TRUE
+"213570_at",0.9202957869034,0.660861755116924,-0.444683855261423,-5.84382606207183,-0.153678240935234,"EIF4E2","eukaryotic translation initiation factor 4E family member 2",TRUE
+"238461_at",0.768852835478002,0.273629365240965,-1.12259043244289,-5.34384253633462,-1.08523953260718,"EIF4E3","eukaryotic translation initiation factor 4E family member 3",TRUE
+"225940_at",0.91238586368984,0.633078417939417,-0.484081463803117,-5.82618764737262,-0.354044517763764,"EIF4E3","eukaryotic translation initiation factor 4E family member 3",TRUE
+"225939_at",0.945819521856653,0.75527708091326,-0.315576692102334,-5.89129358901997,-0.265993559582907,"EIF4E3","eukaryotic translation initiation factor 4E family member 3",TRUE
+"225941_at",0.983935461205724,0.921376044205331,-0.0998312981154891,-5.93483043482391,-0.0936742680386029,"EIF4E3","eukaryotic translation initiation factor 4E family member 3",TRUE
+"221539_at",0.813021318305036,0.36221823470513,-0.930346354595884,-5.52667900706997,-0.524010089817695,"EIF4EBP1","eukaryotic translation initiation factor 4E binding protein 1",TRUE
+"208770_s_at",0.680972290639028,0.148922938164793,-1.49538160360512,-4.90553628441609,-0.58625664946263,"EIF4EBP2","eukaryotic translation initiation factor 4E binding protein 2",TRUE
+"1570454_at",0.697172073261335,0.167580660191823,-1.42679172399079,-4.99399674299051,-0.924325557943505,"EIF4EBP2","eukaryotic translation initiation factor 4E binding protein 2",TRUE
+"208769_at",0.920215208611312,0.660467950915869,0.44523717050247,-5.84358849719855,0.147839403153068,"EIF4EBP2","eukaryotic translation initiation factor 4E binding protein 2",TRUE
+"224645_at",0.97304633500821,0.869245261585359,-0.166536409589662,-5.92618411015213,-0.0498037734325116,"EIF4EBP2","eukaryotic translation initiation factor 4E binding protein 2",TRUE
+"224653_at",0.990810941805126,0.955275326901449,0.0567216701710675,-5.93811655071697,0.0146135310182682,"EIF4EBP2","eukaryotic translation initiation factor 4E binding protein 2",TRUE
+"218626_at",0.682539393883246,0.150428786635791,-1.48959475006112,-4.91312920137526,-0.50473120153503,"EIF4ENIF1","eukaryotic translation initiation factor 4E nuclear import factor 1",TRUE
+"242291_at",0.823074246722209,0.389218839227967,0.878276392154657,-5.57080345475783,0.398901950037009,"EIF4ENIF1","eukaryotic translation initiation factor 4E nuclear import factor 1",TRUE
+"208625_s_at",0.860085676417428,0.479307717396209,-0.719576572672371,-5.69058549420769,-0.17915568510135,"EIF4G1","eukaryotic translation initiation factor 4 gamma 1",TRUE
+"208624_s_at",0.96649413975112,0.843641211294495,0.199564670351394,-5.92030427188594,0.0527380333222158,"EIF4G1","eukaryotic translation initiation factor 4 gamma 1",TRUE
+"1557964_at",0.411281725160037,0.0163307300765837,-2.59889447852949,-3.09625665647908,-1.09441412527862,"EIF4G2","eukaryotic translation initiation factor 4 gamma 2",TRUE
+"217607_x_at",0.820288124919738,0.37872758004398,0.898216633886125,-5.55418341532061,0.342197239610349,"EIF4G2","eukaryotic translation initiation factor 4 gamma 2",TRUE
+"200004_at",0.829965377503324,0.401675928162955,-0.855048357247604,-5.58972678948385,-0.202209456799206,"EIF4G2","eukaryotic translation initiation factor 4 gamma 2",TRUE
+"1554310_a_at",0.617775129514679,0.088507393882987,-1.78172225244443,-4.50152376938908,-0.556232309091366,"EIF4G3","eukaryotic translation initiation factor 4 gamma 3",TRUE
+"201936_s_at",0.809411730389276,0.352611346808888,-0.94949529194094,-5.50986410247335,-0.312051654431745,"EIF4G3","eukaryotic translation initiation factor 4 gamma 3",TRUE
+"201935_s_at",0.948429371744093,0.765282670898145,0.302247171262,-5.89528632008543,0.107309451900385,"EIF4G3","eukaryotic translation initiation factor 4 gamma 3",TRUE
+"1554309_at",0.978928101156583,0.897415105002279,0.130414761857867,-5.93140289983785,0.078645621593255,"EIF4G3","eukaryotic translation initiation factor 4 gamma 3",TRUE
+"206621_s_at",0.820442898002464,0.379521674221628,-0.89669476812764,-5.55546405339581,-0.228828962518465,"EIF4H","eukaryotic translation initiation factor 4H",TRUE
+"208705_s_at",0.925511384407886,0.678271805781584,0.420359278410943,-5.85398304618138,0.140134837018232,"EIF5","eukaryotic translation initiation factor 5",TRUE
+"208707_at",0.945478751548889,0.753477826474407,-0.317979801963197,-5.89055560305287,-0.11330106614516,"EIF5","eukaryotic translation initiation factor 5",TRUE
+"208706_s_at",0.950214160603623,0.773861716736967,0.290862537660476,-5.89856124380206,0.0983504897020726,"EIF5","eukaryotic translation initiation factor 5",TRUE
+"208290_s_at",0.979657792151916,0.903202377444788,0.123017410870352,-5.93231530333776,0.0464201665175867,"EIF5","eukaryotic translation initiation factor 5",TRUE
+"208708_x_at",0.998870448604467,0.995844073892822,-0.00526778967704633,-5.93966996494716,-0.00200855047497761,"EIF5","eukaryotic translation initiation factor 5",TRUE
+"201123_s_at",0.821710721148425,0.384382576912183,0.88742420027776,-5.56322174118744,0.864992002583787,"EIF5A","eukaryotic translation initiation factor 5A",TRUE
+"201122_x_at",0.920491425364243,0.661562609000532,0.443699467951321,-5.84424799043061,0.297501055225856,"EIF5A","eukaryotic translation initiation factor 5A",TRUE
+"213753_x_at",0.95500955665399,0.794697207116353,0.263372624645619,-5.9059546383869,0.119818336438536,"EIF5A","eukaryotic translation initiation factor 5A",TRUE
+"235296_at",0.643082025527735,0.113351798934132,1.64853379015061,-4.69618027942281,1.45522640933858,"EIF5A2","eukaryotic translation initiation factor 5A2",TRUE
+"235289_at",0.695812999227098,0.165992773091234,1.4323820152208,-4.98691354446128,1.57551931246084,"EIF5A2","eukaryotic translation initiation factor 5A2",TRUE
+"220198_s_at",0.740864776127506,0.231168780626159,1.23116880445193,-5.2271983876016,1.50258246980427,"EIF5A2","eukaryotic translation initiation factor 5A2",TRUE
+"214314_s_at",0.811527120049391,0.355714928843115,-0.943271075729048,-5.51536414201005,-0.342855520591099,"EIF5B","eukaryotic translation initiation factor 5B",TRUE
+"201025_at",0.842167419664876,0.435497703801468,-0.794209852994427,-5.63704205672855,-0.268689381271255,"EIF5B","eukaryotic translation initiation factor 5B",TRUE
+"201024_x_at",0.849189309967511,0.450003970371542,-0.769016402603733,-5.65567435222228,-0.221924434084967,"EIF5B","eukaryotic translation initiation factor 5B",TRUE
+"201027_s_at",0.853793505235478,0.462608434723076,-0.747522742403915,-5.67112176374785,-0.221259923895056,"EIF5B","eukaryotic translation initiation factor 5B",TRUE
+"214313_s_at",0.885029460971826,0.546030224891708,-0.613134768839363,-5.75822005447336,-0.250918119266422,"EIF5B","eukaryotic translation initiation factor 5B",TRUE
+"201026_at",0.980808506518944,0.909810502925545,-0.114579401117323,-5.93329112438504,-0.0422940033013184,"EIF5B","eukaryotic translation initiation factor 5B",TRUE
+"210213_s_at",0.8920930097751,0.564034431047619,-0.585641802277514,-5.77399898827613,-0.229274862422862,"EIF6","eukaryotic translation initiation factor 6",TRUE
+"222869_s_at",0.822850703882235,0.388538148802202,0.879559424305446,-5.5697444695046,0.757605859221566,"ELAC1","elaC ribonuclease Z 1",TRUE
+"219325_s_at",0.861659105448003,0.483438189530147,0.712752692327642,-5.69523105613259,0.286026897612746,"ELAC1","elaC ribonuclease Z 1",TRUE
+"201766_at",0.792436690618566,0.323990665903212,1.00873706563112,-5.45586451392764,0.376232544010197,"ELAC2","elaC ribonuclease Z 2",TRUE
+"201767_s_at",0.951257505814081,0.777017168477148,-0.286685099138929,-5.89973166060603,-0.169807650545742,"ELAC2","elaC ribonuclease Z 2",TRUE
+"206871_at",0.439717285988889,0.0202629279217499,-2.50097662346094,-3.28061033604707,-1.49771212018342,"ELANE","elastase, neutrophil expressed",TRUE
+"201727_s_at",0.755820263931272,0.2501566057778,1.18091940399152,-5.28234916162398,0.368657790474781,"ELAVL1","ELAV like RNA binding protein 1",TRUE
+"227746_at",0.755940660414394,0.250591778726674,1.17980184050903,-5.2835529938218,0.653724526519279,"ELAVL1","ELAV like RNA binding protein 1",TRUE
+"244660_at",0.854400503339099,0.465887750297326,0.741988334570239,-5.67503218889051,0.612187732192074,"ELAVL1","ELAV like RNA binding protein 1",TRUE
+"201726_at",0.947969282616012,0.763695147013953,0.304358292283074,-5.89466533268891,0.0717901241417191,"ELAVL1","ELAV like RNA binding protein 1",TRUE
+"228260_at",0.384135218769668,0.0123050085171517,2.72541246489923,-2.85298427714398,2.73570529546592,"ELAVL2","ELAV like neuron-specific RNA binding protein 2",TRUE
+"208427_s_at",0.393258278493143,0.0134317661136022,2.68646773277351,-2.92844673007662,2.34124276402105,"ELAVL2","ELAV like neuron-specific RNA binding protein 2",TRUE
+"206338_at",0.847797601020174,0.447236996042175,0.773783226771517,-5.65219240419448,0.31186646824407,"ELAVL3","ELAV like neuron-specific RNA binding protein 3",TRUE
+"227612_at",0.85463333818278,0.46629708456879,0.741299140307306,-5.675517221366,0.304721086253075,"ELAVL3","ELAV like neuron-specific RNA binding protein 3",TRUE
+"1555602_a_at",0.993053762737399,0.966865685321216,0.0420116755479556,-5.93882386019891,0.017379071859962,"ELAVL3","ELAV like neuron-specific RNA binding protein 3",TRUE
+"238073_at",0.71454754703986,0.189487305470662,1.35367991936671,-5.0845241782186,0.691773490926071,"ELAVL4","ELAV like neuron-specific RNA binding protein 4",TRUE
+"234904_x_at",0.877740599174557,0.528406856805455,0.640515421471331,-5.74181246322564,0.529838250628939,"ELAVL4","ELAV like neuron-specific RNA binding protein 4",TRUE
+"241424_at",0.940044918888428,0.73082902844879,-0.348399202068097,-5.88073509316393,-0.264137355895913,"ELAVL4","ELAV like neuron-specific RNA binding protein 4",TRUE
+"206051_at",0.990810941805126,0.955190638303168,-0.0568291965341724,-5.93811060474037,-0.0377763318009388,"ELAVL4","ELAV like neuron-specific RNA binding protein 4",TRUE
+"212420_at",0.83176405048326,0.406659262488827,0.845886015274173,-5.59706121344822,0.402870903259563,"ELF1","E74 like ETS transcription factor 1",TRUE
+"212418_at",0.890480017681882,0.559157932639312,0.59304262886868,-5.76982024776589,0.34635860316838,"ELF1","E74 like ETS transcription factor 1",TRUE
+"210361_s_at",0.633411263775153,0.104670704493983,-1.69196477490485,-4.63395220334259,-0.530740601012454,"ELF2","E74 like ETS transcription factor 2",TRUE
+"203822_s_at",0.961561244483099,0.825973410110053,0.222486362229705,-5.91560248576234,0.0701776279383992,"ELF2","E74 like ETS transcription factor 2",TRUE
+"242735_x_at",0.986421906591669,0.936605094049995,-0.0804455772151666,-5.93653194762894,-0.0275847227370054,"ELF2","E74 like ETS transcription factor 2",TRUE
+"201510_at",0.953983577550391,0.788541823125892,0.271471388195699,-5.90385213814335,0.243147430719567,"ELF3","E74 like ETS transcription factor 3",TRUE
+"210827_s_at",0.960614707352139,0.821162692517352,-0.228748291821582,-5.91422960983445,-0.213626295101502,"ELF3","E74 like ETS transcription factor 3",TRUE
+"229842_at",0.995111934465262,0.977245183160835,-0.0288466111288668,-5.93927819050789,-0.0298723135964654,"ELF3","E74 like ETS transcription factor 3",TRUE
+"203490_at",0.643688366500038,0.114339649948958,1.64377124278338,-4.70292899608796,1.25773494781532,"ELF4","E74 like ETS transcription factor 4",TRUE
+"31845_at",0.746535697909741,0.238320818611174,1.21188887834443,-5.24859453958323,0.737957809735194,"ELF4","E74 like ETS transcription factor 4",TRUE
+"220624_s_at",0.925511384407886,0.678031056270478,0.420693857374202,-5.85384714620978,0.613242125152188,"ELF5","E74 like ETS transcription factor 5",TRUE
+"220625_s_at",0.985361089461736,0.927524163115132,-0.0920008002353632,-5.93556174741167,-0.157262315964472,"ELF5","E74 like ETS transcription factor 5",TRUE
+"229581_at",0.82847108093969,0.398496931537856,-0.860931374453593,-5.58497864955643,-0.597704129710266,"ELFN1","extracellular leucine rich repeat and fibronectin type III domain containing 1",TRUE
+"231443_at",0.861709844431588,0.483916936806921,0.711963956758732,-5.69576529508235,0.294848265136245,"ELFN1-AS1","ELFN1 antisense RNA 1",TRUE
+"1559072_a_at",0.463552233135475,0.0236759642904845,2.42943236520185,-3.41296631031317,2.07806369128588,"ELFN2","extracellular leucine rich repeat and fibronectin type III domain containing 2",TRUE
+"1560713_a_at",0.525405708458677,0.0392473039501541,2.19108713171884,-3.83809502366192,2.03778072964548,"ELFN2","extracellular leucine rich repeat and fibronectin type III domain containing 2",TRUE
+"1563108_at",0.858363423465728,0.474104404726174,0.728221908307174,-5.68463948357244,0.399252067927963,"ELFN2","extracellular leucine rich repeat and fibronectin type III domain containing 2",TRUE
+"1561369_at",0.918041148686074,0.651824670658542,0.457417427703543,-5.83828555391838,0.162425324535271,"ELFN2","extracellular leucine rich repeat and fibronectin type III domain containing 2",TRUE
+"203617_x_at",0.828013985790299,0.39765873322143,-0.862487560579384,-5.58371759474753,-0.237877737422171,"ELK1","ELK1, ETS transcription factor",TRUE
+"210376_x_at",0.912041701968169,0.631477641341413,-0.486374660944591,-5.82511588506304,-0.162066182059023,"ELK1","ELK1, ETS transcription factor",TRUE
+"210850_s_at",0.963675080804196,0.834198041140956,0.211801559005572,-5.91785746694722,0.0951287507341361,"ELK1","ELK1, ETS transcription factor",TRUE
+"217039_x_at",0.809020025635536,0.352178938371532,-0.950365418921062,-5.5090925720249,-0.260046047900426,"ELK2AP","ELK2A, member of ETS oncogene family, pseudogene",TRUE
+"206127_at",0.567292616148537,0.0574381318405166,2.00406560541634,-4.15259359902509,1.37950793431097,"ELK3","ELK3, ETS transcription factor",TRUE
+"221773_at",0.633978046140253,0.1048687233524,1.69094068894816,-4.63543361561841,1.60049676918792,"ELK3","ELK3, ETS transcription factor",TRUE
+"206919_at",0.48580305784244,0.02848577101314,-2.34335803300977,-3.56940563924676,-0.960390762926527,"ELK4","ELK4, ETS transcription factor",TRUE
+"1556618_at",0.737123149977386,0.222749458167406,-1.25445454497064,-5.20096891354194,-1.00361700355152,"ELK4","ELK4, ETS transcription factor",TRUE
+"205994_at",0.856307880247001,0.470260638542231,-0.734644182560063,-5.68017876500211,-0.249775540856082,"ELK4","ELK4, ETS transcription factor",TRUE
+"230549_at",0.884359306770494,0.543529518625391,-0.616990897269202,-5.75595107704158,-0.387919275666019,"ELK4","ELK4, ETS transcription factor",TRUE
+"225159_s_at",0.905462783815257,0.61132180508895,-0.515481726816645,-5.8110825787748,-0.198089595411929,"ELK4","ELK4, ETS transcription factor",TRUE
+"214831_at",0.923124080520773,0.67048805312182,-0.431201668089864,-5.84952499477657,-0.136724566854164,"ELK4","ELK4, ETS transcription factor",TRUE
+"238761_at",0.994098505325585,0.972848168854878,-0.0344228849430016,-5.93910635907507,-0.0147275098224249,"ELK4","ELK4, ETS transcription factor",TRUE
+"204096_s_at",0.877857073443889,0.528942392013605,-0.639676187857255,-5.74232560837195,-0.193454257254233,"ELL","elongation factor for RNA polymerase II",TRUE
+"1565254_s_at",0.8877101263145,0.552716183587879,0.602870540392906,-5.76419272368673,0.254456817654638,"ELL","elongation factor for RNA polymerase II",TRUE
+"204095_s_at",0.954054753819891,0.789191474388926,-0.270615762423153,-5.90407725230095,-0.0944942055859572,"ELL","elongation factor for RNA polymerase II",TRUE
+"226099_at",0.604366481715437,0.0785814598722459,-1.84410876656752,-4.40654101877231,-2.49018989976288,"ELL2","elongation factor for RNA polymerase II 2",TRUE
+"226982_at",0.789795896476304,0.318144818482436,-1.02127839060869,-5.44405262854234,-1.16258783076839,"ELL2","elongation factor for RNA polymerase II 2",TRUE
+"214446_at",0.920835753388243,0.663441605695224,-0.441062508140542,-5.84537372387227,-0.636623678883196,"ELL2","elongation factor for RNA polymerase II 2",TRUE
+"214445_at",0.98539961718117,0.927868442409737,-0.0915624907862552,-5.93560091940044,-0.0673449806439557,"ELL2","elongation factor for RNA polymerase II 2",TRUE
+"219517_at",0.7609126390691,0.260011537919122,-1.15595759070907,-5.30900007131382,-0.902307174812828,"ELL3","elongation factor for RNA polymerase II 3",TRUE
+"219518_s_at",0.812302873476553,0.357887207572697,-0.938936337654345,-5.51917493689861,-0.714577297676129,"ELL3","elongation factor for RNA polymerase II 3",TRUE
+"204513_s_at",0.603702127972549,0.0778310710901819,1.84909823685186,-4.3988433798797,1.72553108262028,"ELMO1","engulfment and cell motility 1",TRUE
+"55692_at",0.609886795316146,0.0819561757091363,-1.82216890931716,-4.44021268599957,-0.732044763341936,"ELMO2","engulfment and cell motility 2",TRUE
+"221528_s_at",0.649220725475646,0.119949483055489,-1.61736291657997,-4.74007815045196,-0.631960336113536,"ELMO2","engulfment and cell motility 2",TRUE
+"220363_s_at",0.789661545166663,0.317383528207652,-1.02292344089128,-5.44249346956792,-0.373150817308101,"ELMO2","engulfment and cell motility 2",TRUE
+"1554857_at",0.830635993561085,0.404297598268713,0.850219157605881,-5.59360172958199,0.514981828089168,"ELMO2","engulfment and cell motility 2",TRUE
+"219411_at",0.980009054680439,0.905862426927404,-0.119619690833836,-5.9327165597655,-0.0966244393215341,"ELMO3","engulfment and cell motility 3",TRUE
+"226502_at",0.690937549779432,0.160609082093602,-1.45166180240903,-4.96231159732182,-0.383189040582325,"ELMOD2","ELMO domain containing 2",TRUE
+"1553928_at",0.760237493549547,0.258444400257443,-1.159879523521,-5.30484579354919,-0.316193525210867,"ELMOD2","ELMO domain containing 2",TRUE
+"1557836_at",0.820536502908875,0.380050131725128,0.895683149500337,-5.55631421101155,0.578461693364825,"ELMOD2","ELMO domain containing 2",TRUE
+"233912_x_at",0.893600768892136,0.568581846102199,0.578770038896868,-5.77783354328443,0.33505183242734,"ELMOD2","ELMO domain containing 2",TRUE
+"1557837_a_at",0.933400538871064,0.705440503332659,0.382902997952245,-5.86852406951964,0.231094165819012,"ELMOD2","ELMO domain containing 2",TRUE
+"226286_at",0.0533657154833195,8.39405858539639e-05,-4.8007622038892,1.5255895662243,-2.22198861538688,"ELMOD3","ELMO domain containing 3",TRUE
+"225980_at",0.686108994812404,0.15478405376602,-1.47311919896113,-4.93461679032435,-0.594791225647691,"ELMSAN1","ELM2 and Myb/SANT domain containing 1",TRUE
+"235430_at",0.821137675198948,0.38215195711437,-0.891668771773676,-5.55967911241561,-0.35138618217321,"ELMSAN1","ELM2 and Myb/SANT domain containing 1",TRUE
+"212670_at",0.774230543658252,0.288793823317801,1.08683157737249,-5.38017830131742,0.383808731864046,"ELN","elastin",TRUE
+"216269_s_at",0.802190559985596,0.339876439361067,0.975431596822875,-5.48658936427859,0.543687801325884,"ELN","elastin",TRUE
+"225156_at",0.874573785074124,0.52100123920712,0.652168687333062,-5.73462035085441,0.23326775926056,"ELOF1","elongation factor 1 homolog",TRUE
+"220029_at",0.920295529438727,0.660654098053301,-0.444975606573464,-5.84370083530689,-0.554029609450417,"ELOVL2","ELOVL fatty acid elongase 2",TRUE
+"213712_at",0.974982245454858,0.877905218036826,-0.155410031674872,-5.92792663881199,-0.278934067507512,"ELOVL2","ELOVL fatty acid elongase 2",TRUE
+"237365_at",0.969859842767097,0.855995547737888,0.18360199865231,-5.92327805654165,0.170813228182195,"ELOVL2-AS1","ELOVL2 antisense RNA 1",TRUE
+"234513_at",0.800887499728059,0.336802718616955,0.981790762593612,-5.48079541278714,0.906505634045707,"ELOVL3","ELOVL fatty acid elongase 3",TRUE
+"219532_at",0.732320150624823,0.216675067634232,1.27167617805685,-5.18129914635724,1.74366440261212,"ELOVL4","ELOVL fatty acid elongase 4",TRUE
+"1567222_x_at",0.756313947022433,0.251421201092097,1.17767581225699,-5.28584038941704,0.332442187419026,"ELOVL5","ELOVL fatty acid elongase 5",TRUE
+"214153_at",0.821745015752602,0.384727845303455,0.886768642197964,-5.56376749075415,0.50669773616712,"ELOVL5","ELOVL fatty acid elongase 5",TRUE
+"215082_at",0.921006039723366,0.663876992238138,0.440451946107367,-5.84563343744374,0.16877162230852,"ELOVL5","ELOVL fatty acid elongase 5",TRUE
+"208788_at",0.939976205834042,0.730060656009265,0.349436931553378,-5.8803844373809,0.128490807472195,"ELOVL5","ELOVL fatty acid elongase 5",TRUE
+"204256_at",0.970168534776033,0.858361823525484,0.180550296638709,-5.92381845850573,0.122304610804907,"ELOVL6","ELOVL fatty acid elongase 6",TRUE
+"227491_at",0.971469873887034,0.864212907148421,-0.1730118247505,-5.92511468312887,-0.0923773384462541,"ELOVL6","ELOVL fatty acid elongase 6",TRUE
+"210868_s_at",0.986421906591669,0.936336464504959,-0.0807872316065126,-5.93650512572148,-0.0457776837372155,"ELOVL6","ELOVL fatty acid elongase 6",TRUE
+"227180_at",0.948429371744093,0.765333534200957,0.30217955545122,-5.89530613850577,0.203870952905705,"ELOVL7","ELOVL fatty acid elongase 7",TRUE
+"230178_s_at",0.552420073963858,0.0496411444264235,-2.0765759383728,-4.03280579814112,-1.53303636039014,"ELP2","elongator acetyltransferase complex subunit 2",TRUE
+"231713_s_at",0.886916043359667,0.550499532966898,-0.606266239419663,-5.76222756507813,-0.346026301271726,"ELP2","elongator acetyltransferase complex subunit 2",TRUE
+"243735_at",0.890004377648073,0.558295011410026,-0.594355718275204,-5.76907353716812,-0.517081751177344,"ELP2","elongator acetyltransferase complex subunit 2",TRUE
+"235623_at",0.948109877411639,0.764383620487976,-0.303442573679569,-5.89493521793365,-0.110486779822966,"ELP2","elongator acetyltransferase complex subunit 2",TRUE
+"238709_at",0.954627246077849,0.793275487461209,-0.265241592220253,-5.90547505327598,-0.232534390928012,"ELP2","elongator acetyltransferase complex subunit 2",TRUE
+"227075_at",0.84763661356464,0.446507217325564,0.775043441369776,-5.65126848082651,0.276455341964548,"ELP3","elongator acetyltransferase complex subunit 3",TRUE
+"221094_s_at",0.934384170278735,0.709226210636808,0.377729014198016,-5.87042762848809,0.128425319011672,"ELP3","elongator acetyltransferase complex subunit 3",TRUE
+"203829_at",0.929295414003679,0.689165818959436,-0.405269691214057,-5.8600015973592,-0.15254158156673,"ELP4","elongator acetyltransferase complex subunit 4",TRUE
+"219260_s_at",0.58883220882361,0.0675797368151469,1.92183991118015,-4.28495889571678,1.11695433372657,"ELP5","elongator acetyltransferase complex subunit 5",TRUE
+"223286_at",0.987257510450304,0.940558556505625,0.0754185092142913,-5.93691346896135,0.0399118653491204,"ELP5","elongator acetyltransferase complex subunit 5",TRUE
+"220600_at",0.686081665045981,0.154357394819033,-1.47471643850677,-4.93254209745475,-0.698235815426393,"ELP6","elongator acetyltransferase complex subunit 6",TRUE
+"229863_s_at",0.754782975475398,0.248383364584194,-1.18548831443062,-5.27741721519165,-0.409646640335096,"ELP6","elongator acetyltransferase complex subunit 6",TRUE
+"223277_at",0.792716268502624,0.324365797126912,-1.00793768843991,-5.45661291704755,-0.352390146222598,"ELP6","elongator acetyltransferase complex subunit 6",TRUE
+"229864_at",0.945723453271709,0.754987421827226,-0.31596343649463,-5.89117519563715,-0.16278766943327,"ELP6","elongator acetyltransferase complex subunit 6",TRUE
+"220366_at",0.790361168948463,0.320069297795001,1.01713208919609,-5.44797237880209,0.298028941300553,"ELSPBP1","epididymal sperm binding protein 1",TRUE
+"226789_at",0.699161781955613,0.170609907306481,1.41624383559364,-5.00729961483446,1.44956343952967,"EMB","embigin",TRUE
+"239072_at",0.798428326317339,0.332948573753889,0.989821168168582,-5.4734297962406,1.36228953771836,"EMB","embigin",TRUE
+"1556186_s_at",0.78065889313777,0.302283025769232,1.05614347158921,-5.41052433601445,0.442011628868412,"EMC1","ER membrane protein complex subunit 1",TRUE
+"215991_s_at",0.8288884913487,0.399561156226968,0.858958583940231,-5.58657425254742,0.423263520770509,"EMC1","ER membrane protein complex subunit 1",TRUE
+"212394_at",0.839519981963042,0.427141519405864,0.808957251960081,-5.62587320697993,0.375089719803162,"EMC1","ER membrane protein complex subunit 1",TRUE
+"212396_s_at",0.86481525165637,0.492279640945356,0.698258492705102,-5.7049584929224,0.222651352954097,"EMC1","ER membrane protein complex subunit 1",TRUE
+"212395_s_at",0.871744769522775,0.514208667353977,0.66293769009374,-5.72786337612428,0.204535198504701,"EMC1","ER membrane protein complex subunit 1",TRUE
+"224727_at",0.79985507957204,0.335330863825083,0.984849979323266,-5.47799588913854,1.08369051672805,"EMC10","ER membrane protein complex subunit 10",TRUE
+"222345_at",0.937224988740666,0.721329394726512,0.361256820708099,-5.87631771708628,0.229066049377131,"EMC10","ER membrane protein complex subunit 10",TRUE
+"203584_at",0.908709061737317,0.620549878131966,-0.502100960064374,-5.81763264670836,-0.218182825821692,"EMC2","ER membrane protein complex subunit 2",TRUE
+"217882_at",0.544577979658206,0.0466467152713675,-2.10716185077034,-3.98144819282215,-0.854438990582661,"EMC3","ER membrane protein complex subunit 3",TRUE
+"215250_at",0.700890836612645,0.172577477762109,1.40947279998955,-5.01579641030084,0.700719002171939,"EMC3","ER membrane protein complex subunit 3",TRUE
+"228775_at",0.737123149977386,0.222853628159069,-1.25416236611044,-5.20130064449472,-0.439490827398128,"EMC3","ER membrane protein complex subunit 3",TRUE
+"237005_at",0.681784856053315,0.149462702965799,-1.49330186877146,-4.9082678231282,-0.645731402361235,"EMC3-AS1","EMC3 antisense RNA 1",TRUE
+"223043_at",0.937701956744454,0.724360900476199,-0.357147080096976,-5.87774685709961,-0.10790590550034,"EMC4","ER membrane protein complex subunit 4",TRUE
+"223857_x_at",0.993615552413264,0.970118449307244,0.0378852543763118,-5.93898442687116,0.012185969035146,"EMC4","ER membrane protein complex subunit 4",TRUE
+"221255_s_at",0.943294768503521,0.745002911134728,0.329325023179226,-5.88699668037291,0.110876605561067,"EMC6","ER membrane protein complex subunit 6",TRUE
+"217898_at",0.685704169806816,0.154109425488544,-1.47564638366785,-4.93133333260171,-0.45335551690822,"EMC7","ER membrane protein complex subunit 7",TRUE
+"227535_at",0.937271400689562,0.721784630076953,-0.360639265989496,-5.87653349933997,-0.123992290197729,"EMC7","ER membrane protein complex subunit 7",TRUE
+"227363_s_at",0.699161781955613,0.170605900964686,-1.41625768628329,-5.00728219965468,-0.517127083792676,"EMC8","ER membrane protein complex subunit 8",TRUE
+"218057_x_at",0.714791050845163,0.190252967708638,-1.35124843116578,-5.08746679758642,-0.460416580059663,"EMC8","ER membrane protein complex subunit 8",TRUE
+"222504_s_at",0.797963285726587,0.332200436967815,-0.991387385072859,-5.47198687722935,-0.824865550444264,"EMC8","ER membrane protein complex subunit 8",TRUE
+"219203_at",0.726636642789909,0.206245611662087,-1.30213249974522,-5.14595403354095,-0.551618780131619,"EMC9","ER membrane protein complex subunit 9",TRUE
+"227874_at",0.709135917979769,0.181738834651216,-1.37873333377202,-5.05394742662239,-1.02298810266775,"EMCN","endomucin",TRUE
+"222885_at",0.774230543658252,0.286343940247739,1.09251494920902,-5.37447314683505,0.832037650194373,"EMCN","endomucin",TRUE
+"219436_s_at",0.859064198633089,0.475753803796912,0.725475432892433,-5.68653574468305,0.417127891307135,"EMCN","endomucin",TRUE
+"209477_at",0.632949074657601,0.103889340312472,-1.69602183386348,-4.62807674198582,-0.484794937438602,"EMD","emerin",TRUE
+"234465_at",0.812644903778517,0.36132414468872,-0.932113990067771,-5.52514000866512,-0.320379849337433,"EME1","essential meiotic structure-specific endonuclease 1",TRUE
+"234464_s_at",0.990918916504081,0.957364181075472,-0.0540697335057027,-5.93825963442956,-0.0165094914775956,"EME1","essential meiotic structure-specific endonuclease 1",TRUE
+"1569868_s_at",0.571833476034523,0.0598958307674909,-1.98302528359371,-4.18682167297505,-1.16307662733547,"EME2","essential meiotic structure-specific endonuclease subunit 2",TRUE
+"1569867_at",0.647518308302168,0.118434278473587,-1.62439190298669,-4.73023558727469,-0.787151626531177,"EME2","essential meiotic structure-specific endonuclease subunit 2",TRUE
+"1556024_at",0.716219454102037,0.191948123657195,-1.3458924512895,-5.09393305545625,-1.22040725124597,"EME2","essential meiotic structure-specific endonuclease subunit 2",TRUE
+"209233_at",0.828068961116677,0.397802785560692,0.862219964974267,-5.58393459161648,0.507384707470477,"EMG1","EMG1, N1-specific pseudouridine methyltransferase",TRUE
+"213779_at",0.801587742916188,0.338800025574021,-0.977654063212671,-5.48456833521504,-0.646551487160806,"EMID1","EMI domain containing 1",TRUE
+"1564251_at",0.899709895975363,0.591304485024822,-0.544842185707825,-5.79612251262942,-0.300832399186401,"EMID1","EMI domain containing 1",TRUE
+"204163_at",0.769847953580141,0.277548526021406,-1.11321354117769,-5.3534716634361,-0.425474901575515,"EMILIN1","elastin microfibril interfacer 1",TRUE
+"224374_s_at",0.13804695369145,0.000908951135416953,3.82734281332357,-0.572387015609422,2.61400639478993,"EMILIN2","elastin microfibril interfacer 2",TRUE
+"221980_at",0.299994279961527,0.00556087065874721,3.07099800146847,-2.16374674460382,2.00720282194581,"EMILIN2","elastin microfibril interfacer 2",TRUE
+"242288_s_at",0.904381089098038,0.607859799308576,0.520526217116972,-5.80856964853399,0.204092562579291,"EMILIN2","elastin microfibril interfacer 2",TRUE
+"228307_at",0.965318866725958,0.838304620228902,-0.206476114011135,-5.91894012415318,-0.104216538151508,"EMILIN3","elastin microfibril interfacer 3",TRUE
+"204796_at",0.786851686785014,0.312584032138446,-1.03335880210248,-5.43255020539072,-1.01078783328753,"EML1","echinoderm microtubule associated protein like 1",TRUE
+"204797_s_at",0.797896456623304,0.331860774406952,-0.992099269133295,-5.47133034955497,-1.26540811158779,"EML1","echinoderm microtubule associated protein like 1",TRUE
+"204398_s_at",0.818852235468236,0.372682493337277,0.90987145440192,-5.54430945472365,0.335759898959491,"EML2","echinoderm microtubule associated protein like 2",TRUE
+"234021_at",0.823074246722209,0.389674478509756,0.8774183737494,-5.57151084295229,0.424964640659651,"EML2","echinoderm microtubule associated protein like 2",TRUE
+"204399_s_at",0.84231658612216,0.4359700851593,0.793381418883949,-5.63766373432068,0.337216631776998,"EML2","echinoderm microtubule associated protein like 2",TRUE
+"204397_at",0.906476756086155,0.614006963054886,0.511578495529176,-5.81301061783593,0.27196810736643,"EML2","echinoderm microtubule associated protein like 2",TRUE
+"1569086_at",0.835952408568777,0.417003811444609,-0.827092232870876,-5.61187459746671,-0.364408547802299,"EML2-AS1","EML2 antisense RNA 1",TRUE
+"234026_at",0.97928472590149,0.899340471869212,-0.127952931628043,-5.93171245091749,-0.0698018609737616,"EML2-AS1","EML2 antisense RNA 1",TRUE
+"203443_at",0.55074985379986,0.0490827205547952,2.08215191758543,-4.02347912402498,1.21835907186567,"EML3","echinoderm microtubule associated protein like 3",TRUE
+"212969_x_at",0.778031107955451,0.297387911007604,-1.06716450241474,-5.39971565508861,-0.478897955794844,"EML3","echinoderm microtubule associated protein like 3",TRUE
+"203442_x_at",0.841967750949524,0.43443467445746,-0.79607615921226,-5.63563929786873,-0.317926052182173,"EML3","echinoderm microtubule associated protein like 3",TRUE
+"228674_s_at",0.603329945678563,0.0774716935503464,1.85150263901036,-4.39512863698274,0.677575725164632,"EML4","echinoderm microtubule associated protein like 4",TRUE
+"1556732_at",0.672434875127089,0.138404639901101,1.53719464720385,-4.84997485453968,0.743302298212862,"EML4","echinoderm microtubule associated protein like 4",TRUE
+"232587_at",0.712391714067656,0.186414051269611,1.36351816080532,-5.07257270412594,0.557523529183553,"EML4","echinoderm microtubule associated protein like 4",TRUE
+"220386_s_at",0.74413941468137,0.234851271873909,1.22118631316691,-5.23831304599262,0.446460824989689,"EML4","echinoderm microtubule associated protein like 4",TRUE
+"228673_s_at",0.762457485780444,0.261892118572597,1.15127424617633,-5.31394467782699,0.531936243286578,"EML4","echinoderm microtubule associated protein like 4",TRUE
+"223069_s_at",0.7768734672127,0.294912144658391,1.07278790292515,-5.39416189983946,0.36464672367987,"EML4","echinoderm microtubule associated protein like 4",TRUE
+"223068_at",0.806307740057893,0.347165807200784,0.960506507931236,-5.50005289521134,0.323020528890016,"EML4","echinoderm microtubule associated protein like 4",TRUE
+"1568777_at",0.804466873655748,0.343209772197421,0.968579703233179,-5.49279381259358,0.444319092517886,"EML5","echinoderm microtubule associated protein like 5",TRUE
+"1570393_at",0.952697366942815,0.783632864294063,-0.277943499022412,-5.9021264819719,-0.194191526828225,"EML5","echinoderm microtubule associated protein like 5",TRUE
+"242785_at",0.862634144901168,0.485761138784039,-0.708929854289086,-5.69781515025429,-0.453906076139295,"EML6","echinoderm microtubule associated protein like 6",TRUE
+"229656_s_at",0.879161148925378,0.532899227721196,-0.633489705053185,-5.7460883403057,-0.493524155820067,"EML6","echinoderm microtubule associated protein like 6",TRUE
+"1564796_at",0.163850812837738,0.00131754359615132,3.67455598083259,-0.899685390239267,2.54437114700813,"EMP1","epithelial membrane protein 1",TRUE
+"213895_at",0.209119042035931,0.00242476981605989,3.42148759487725,-1.43658070665462,2.57862518797636,"EMP1","epithelial membrane protein 1",TRUE
+"201324_at",0.348854934125219,0.00916913533120963,2.85486665791425,-2.59871140837178,4.30283995054973,"EMP1","epithelial membrane protein 1",TRUE
+"201325_s_at",0.360736459722853,0.0103572071934998,2.80147996901699,-2.70419055395495,4.14664891159582,"EMP1","epithelial membrane protein 1",TRUE
+"229011_at",0.446813254770728,0.0210188146551498,2.48421427961195,-3.31180320921635,2.51824838100704,"EMP1","epithelial membrane protein 1",TRUE
+"234233_s_at",0.610033432202476,0.0824278452467924,1.81916515528567,-4.44480010578741,1.29780352755715,"EMP1","epithelial membrane protein 1",TRUE
+"225079_at",0.606900628956089,0.0801649988130551,-1.83371399714585,-4.42253011731937,-1.43695538839762,"EMP2","epithelial membrane protein 2",TRUE
+"225078_at",0.676413305074233,0.143136820389455,-1.5180716825333,-4.87553724628526,-1.43563766231216,"EMP2","epithelial membrane protein 2",TRUE
+"204975_at",0.685154158710982,0.153762258460795,-1.4769503880458,-4.92963732010718,-1.14360517762514,"EMP2","epithelial membrane protein 2",TRUE
+"238500_at",0.773427028595643,0.284841822547817,-1.09601701954449,-5.3709444607147,-0.613830343714583,"EMP2","epithelial membrane protein 2",TRUE
+"203729_at",0.724590981430178,0.201789943997728,1.31550882525097,-5.13020643632106,1.98574028120692,"EMP3","epithelial membrane protein 3",TRUE
+"222807_at",0.609539262323192,0.0818339347566648,-1.82294982546065,-4.43901915669778,-0.829235525458241,"EMSY","EMSY, BRCA2 interacting transcriptional repressor",TRUE
+"219012_s_at",0.702621412021935,0.173978450478915,-1.40468912169588,-5.02177911007692,-0.603698980859835,"EMSY","EMSY, BRCA2 interacting transcriptional repressor",TRUE
+"234669_x_at",0.732609624187962,0.216948924101094,1.27089183533895,-5.1821999716165,0.991572570775223,"EMSY","EMSY, BRCA2 interacting transcriptional repressor",TRUE
+"222806_s_at",0.866611803190887,0.497874729111304,-0.689163295036241,-5.71096515833326,-0.299260692590142,"EMSY","EMSY, BRCA2 interacting transcriptional repressor",TRUE
+"1569349_at",0.917102138198416,0.649590582318777,0.460577129615243,-5.83688699434238,0.198655324783561,"EMSY","EMSY, BRCA2 interacting transcriptional repressor",TRUE
+"242847_at",0.975398143273847,0.881136092561658,-0.151264195420024,-5.9285451999947,-0.0727888677251736,"EMSY","EMSY, BRCA2 interacting transcriptional repressor",TRUE
+"215265_at",0.901788521024914,0.599298764274163,0.533059825391351,-5.80222283859746,0.362312263290493,"EMX1","empty spiracles homeobox 1",TRUE
+"215264_at",0.908425207680517,0.619340796369437,-0.503848805399953,-5.81678659452971,-0.505205296651041,"EMX1","empty spiracles homeobox 1",TRUE
+"221950_at",0.981944022360435,0.913644351646652,-0.109687848290273,-5.93382511619978,-0.116598635993105,"EMX2","empty spiracles homeobox 2",TRUE
+"232531_at",0.846452477724539,0.444505597447224,0.778506376632979,-5.64872233449874,0.512014203300153,"EMX2OS","EMX2 opposite strand/antisense RNA",TRUE
+"230963_at",0.9181984176728,0.652589405304299,-0.45633693989933,-5.83876163883179,-0.266317469198232,"EMX2OS","EMX2 opposite strand/antisense RNA",TRUE
+"220559_at",0.879665002659836,0.534215031602423,0.631437969197975,-5.74732847646732,0.685633606090874,"EN1","engrailed homeobox 1",TRUE
+"207060_at",0.693039857710647,0.162336743625062,-1.44541877666343,-4.97030736336459,-1.44187373896219,"EN2","engrailed homeobox 2",TRUE
+"228553_at",0.627092759817312,0.0980496192894996,-1.72719331952998,-4.58258233611478,-0.709384015689825,"ENAH","enabled homolog (Drosophila)",TRUE
+"217820_s_at",0.807064481254599,0.348259209990668,-0.95828622468622,-5.50203954279653,-0.450549947948783,"ENAH","enabled homolog (Drosophila)",TRUE
+"222433_at",0.836592953877091,0.41833327666752,-0.824698353652233,-5.61373911668661,-0.43566402996909,"ENAH","enabled homolog (Drosophila)",TRUE
+"1553672_at",0.90466378569832,0.608789623455538,0.519170031397293,-5.80924758065008,0.253560742210987,"ENAH","enabled homolog (Drosophila)",TRUE
+"228310_at",0.992583835836326,0.965371356403375,0.0439076112326544,-5.93874452592143,0.0199399352158078,"ENAH","enabled homolog (Drosophila)",TRUE
+"222434_at",0.999503346640971,0.998830631374595,0.00148221128018513,-5.93968241069568,0.000669008046887853,"ENAH","enabled homolog (Drosophila)",TRUE
+"240586_at",0.579111490485788,0.0620854480627746,1.96491480987773,-4.21608809435454,1.80441388879375,"ENAM","enamelin",TRUE
+"223893_at",0.989188193460971,0.947322962922907,-0.0668216982139988,-5.93750890999233,-0.0313842877592272,"ENAM","enamelin",TRUE
+"201340_s_at",0.637176949657524,0.108067321484918,1.67462156771888,-4.65894888043414,1.01751814445665,"ENC1","ectodermal-neural cortex 1",TRUE
+"201341_at",0.796963640275795,0.329852853272979,0.996317904490091,-5.46743096989404,0.554197299910095,"ENC1","ectodermal-neural cortex 1",TRUE
+"212573_at",0.756313947022433,0.251559094146106,1.17732286323528,-5.28621977871631,0.843935925855371,"ENDOD1","endonuclease domain containing 1",TRUE
+"212570_at",0.884769004468037,0.544762025906027,0.615089177083767,-5.75707177873709,0.360867515698938,"ENDOD1","endonuclease domain containing 1",TRUE
+"204824_at",0.304824368772306,0.00601528808387534,-3.03733901815231,-2.23225866099947,-0.942186674622985,"ENDOG","endonuclease G",TRUE
+"206605_at",0.920783004321385,0.663166999193084,0.441447688734348,-5.84520969872873,0.27979148568304,"ENDOU","endonuclease, poly(U) specific",TRUE
+"238400_at",0.83024704628409,0.402041532645955,-0.854373692822048,-5.59026936791136,-0.559605266291499,"ENDOV","endonuclease V",TRUE
+"238401_at",0.904449064651725,0.608334700726323,-0.519833431053013,-5.80891617473232,-0.326493489134027,"ENDOV","endonuclease V",TRUE
+"238402_s_at",0.914535679225538,0.639907807448819,-0.474327322207952,-5.83069105214822,-0.189507726271806,"ENDOV","endonuclease V",TRUE
+"229939_at",0.949740807420078,0.772492020462782,0.292677492487094,-5.89804750432865,0.0894209278577911,"ENDOV","endonuclease V",TRUE
+"201808_s_at",0.48580305784244,0.028345281364911,2.34567518183812,-3.5652357967444,1.86724632667211,"ENG","endoglin",TRUE
+"201809_s_at",0.55937703282623,0.0532050108464214,2.04225793368894,-4.08984875836014,1.52309602696249,"ENG","endoglin",TRUE
+"220349_s_at",0.817755229158552,0.370266761829573,0.914563905255529,-5.54030083633219,0.396551469986544,"ENGASE","endo-beta-N-acetylglucosaminidase",TRUE
+"65635_at",0.819018525257656,0.374742243129008,0.905886366512714,-5.54769884874131,0.224715163616084,"ENGASE","endo-beta-N-acetylglucosaminidase",TRUE
+"228403_at",0.914910510855952,0.641740687092418,-0.471717460718029,-5.83188079415864,-0.480739654625847,"ENHO","energy homeostasis associated",TRUE
+"223407_at",0.97897951922649,0.898114658590729,0.129520197581395,-5.93151606377224,0.117516110051069,"ENKD1","enkurin domain containing 1",TRUE
+"237314_at",0.954723352940649,0.793930562913293,0.264380322082748,-5.90569647736783,0.11836001183384,"ENKUR","enkurin, TRPC channel interacting protein",TRUE
+"240258_at",0.682825347106105,0.15088054182811,1.48786789891409,-4.91539041166737,1.31298252667699,"ENO1","enolase 1",TRUE
+"216554_s_at",0.748438284778152,0.241201707369013,1.20424618574097,-5.25699513334915,0.303227030294241,"ENO1","enolase 1",TRUE
+"217294_s_at",0.797960028258877,0.331946556495133,0.991919434688453,-5.47149624043991,0.41104559710622,"ENO1","enolase 1",TRUE
+"201231_s_at",0.804212866894346,0.342895479708111,0.969223804988816,-5.49221227273475,0.382099626263139,"ENO1","enolase 1",TRUE
+"237028_at",0.87579870142401,0.523685272939219,-0.647934751299268,-5.73724783608668,-0.307729318246148,"ENO1-AS1","ENO1 antisense RNA 1",TRUE
+"201313_at",0.829519289742569,0.400937106019775,0.856412938362992,-5.5886281468884,1.53687062083632,"ENO2","enolase 2",TRUE
+"237691_x_at",0.737535792093258,0.223892065105821,1.25125542407363,-5.20459748595675,0.56864505430072,"ENO3","enolase 3",TRUE
+"204483_at",0.839026687117702,0.424710924780811,0.813280491508623,-5.62256246189935,0.292332792565606,"ENO3","enolase 3",TRUE
+"217956_s_at",0.784498961298069,0.307581842737803,-1.04435563506392,-5.42197354401018,-0.272757212868022,"ENOPH1","enolase-phosphatase 1",TRUE
+"204143_s_at",0.803111243433434,0.34089342092764,0.97333626638666,-5.48849093923145,0.404029656375291,"ENOSF1","enolase superfamily member 1",TRUE
+"217690_at",0.813970831648786,0.364925167017039,0.925012427025498,-5.5313067221552,0.438154151491958,"ENOSF1","enolase superfamily member 1",TRUE
+"204142_at",0.829044392052913,0.400273097779578,0.857640718526206,-5.58763825001894,0.474667757514297,"ENOSF1","enolase superfamily member 1",TRUE
+"213645_at",0.847717593536494,0.446723446515107,0.77466991660966,-5.65154247756013,0.272363248376864,"ENOSF1","enolase superfamily member 1",TRUE
+"219501_at",0.9479037766926,0.762570601149044,0.30585458999806,-5.89422260177001,0.202091881562679,"ENOX1","ecto-NOX disulfide-thiol exchanger 1",TRUE
+"204644_at",0.872668627020452,0.516439036374191,-0.659393008586996,-5.73009919096562,-0.356303549368167,"ENOX2","ecto-NOX disulfide-thiol exchanger 2",TRUE
+"234003_at",0.892961495138818,0.566628369681685,0.58171854202886,-5.77619359602999,0.32868915953236,"ENOX2","ecto-NOX disulfide-thiol exchanger 2",TRUE
+"32042_at",0.895690630367785,0.575587951130472,-0.568237515150342,-5.78362577792537,-0.262104498823913,"ENOX2","ecto-NOX disulfide-thiol exchanger 2",TRUE
+"204643_s_at",0.997171203405,0.98572819362551,-0.0180909850028233,-5.9395240741642,-0.00775220192420534,"ENOX2","ecto-NOX disulfide-thiol exchanger 2",TRUE
+"204844_at",0.676468346171966,0.143256617778955,1.51759435308742,-4.87617205075898,1.55240163804028,"ENPEP","glutamyl aminopeptidase",TRUE
+"204845_s_at",0.780237570670818,0.301720422428897,1.05740364068646,-5.40929354189722,1.14584196830326,"ENPEP","glutamyl aminopeptidase",TRUE
+"229088_at",0.468735421183467,0.0249907630582133,-2.40440428121809,-3.45877715743886,-2.81841287848005,"ENPP1","ectonucleotide pyrophosphatase/phosphodiesterase 1",TRUE
+"205066_s_at",0.561337372739062,0.0547425856688556,-2.0280824747777,-4.11322872873984,-1.99431467805627,"ENPP1","ectonucleotide pyrophosphatase/phosphodiesterase 1",TRUE
+"205065_at",0.763044089435492,0.262847231466448,-1.14890516709531,-5.31643919639464,-1.17593563878627,"ENPP1","ectonucleotide pyrophosphatase/phosphodiesterase 1",TRUE
+"228952_at",0.941908206900417,0.739094358552975,-0.337260772851176,-5.88443391334314,-0.308462404868753,"ENPP1","ectonucleotide pyrophosphatase/phosphodiesterase 1",TRUE
+"209392_at",0.640067422642767,0.110478708861769,1.66258679386964,-4.67617972172667,0.835654002328973,"ENPP2","ectonucleotide pyrophosphatase/phosphodiesterase 2",TRUE
+"210839_s_at",0.891225909060826,0.560409998382912,0.591139254295808,-5.77089979979042,0.254406465262623,"ENPP2","ectonucleotide pyrophosphatase/phosphodiesterase 2",TRUE
+"219912_s_at",0.666021473381655,0.133045935661169,1.5595107773267,-4.81982380397867,1.02062565538187,"ENPP3","ectonucleotide pyrophosphatase/phosphodiesterase 3",TRUE
+"232737_s_at",0.868039927215454,0.501744319303476,0.682907005343116,-5.7150532772694,0.465675321811271,"ENPP3","ectonucleotide pyrophosphatase/phosphodiesterase 3",TRUE
+"222938_x_at",0.980009054680439,0.905452044567483,0.120143783100558,-5.93265539866598,0.03779147106727,"ENPP3","ectonucleotide pyrophosphatase/phosphodiesterase 3",TRUE
+"204160_s_at",0.854343866520736,0.465092456019762,0.743328396623887,-5.6740878736357,0.676720270404847,"ENPP4","ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)",TRUE
+"204161_s_at",0.889452275006221,0.557601576188628,0.595411668727407,-5.76847189516959,0.44895574657476,"ENPP4","ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)",TRUE
+"237054_at",0.977361191903387,0.891503564016565,-0.137978659803632,-5.93041497101025,-0.1390430562197,"ENPP5","ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)",TRUE
+"227803_at",0.990810941805126,0.954789405048558,0.0573386387227134,-5.93808228066623,0.068876867668255,"ENPP5","ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)",TRUE
+"229916_at",0.954577684533304,0.791978365716649,-0.266947607884611,-5.90503434178591,-0.260358389834912,"ENPP6","ectonucleotide pyrophosphatase/phosphodiesterase 6",TRUE
+"238245_at",0.843121215318579,0.437517897860003,-0.790670825383929,-5.63969356407612,-0.586499726655242,"ENPP7","ectonucleotide pyrophosphatase/phosphodiesterase 7",TRUE
+"228851_s_at",0.563949924132502,0.0558019037870477,-2.01852123476451,-4.12893745170596,-0.82251009405713,"ENSA","endosulfine alpha",TRUE
+"228852_at",0.622026794278124,0.0922772625219912,-1.75960360070633,-4.53462741394549,-0.828058711826674,"ENSA","endosulfine alpha",TRUE
+"202596_at",0.654592482818544,0.123476913033666,-1.60128255845552,-4.76247088783935,-0.563951322200529,"ENSA","endosulfine alpha",TRUE
+"221487_s_at",0.721658263642493,0.197880213781953,-1.32743708314598,-5.11604903196829,-0.60012098975213,"ENSA","endosulfine alpha",TRUE
+"221486_at",0.738061563377262,0.224862268013682,-1.24854878780842,-5.20766125014882,-0.436489381676637,"ENSA","endosulfine alpha",TRUE
+"1552394_a_at",0.744688669253745,0.236033222531603,1.21800742121785,-5.24183605009818,1.09201004274507,"ENTHD1","ENTH domain containing 1",TRUE
+"1552393_at",0.8920930097751,0.563461258735622,-0.586509960297614,-5.77351142640679,-0.59656639092459,"ENTHD1","ENTH domain containing 1",TRUE
+"209474_s_at",0.280199223932988,0.00467196095024323,-3.14529368229843,-2.01161041673326,-2.10173002536718,"ENTPD1","ectonucleoside triphosphate diphosphohydrolase 1",TRUE
+"207691_x_at",0.776936981479994,0.295219100809984,-1.0720888596892,-5.39485370664424,-0.432518593406275,"ENTPD1","ectonucleoside triphosphate diphosphohydrolase 1",TRUE
+"209473_at",0.844719457948142,0.441587042470486,-0.78357276269362,-5.64497795837234,-0.516146550965732,"ENTPD1","ectonucleoside triphosphate diphosphohydrolase 1",TRUE
+"228585_at",0.999200977427611,0.997464825752154,-0.00321341714374597,-5.93967845131225,-0.00259661032155734,"ENTPD1","ectonucleoside triphosphate diphosphohydrolase 1",TRUE
+"219731_at",0.955892698633978,0.799480716556796,-0.257091297041324,-5.90754176505185,-0.0829255545693499,"ENTPD1-AS1","ENTPD1 antisense RNA 1",TRUE
+"230430_at",0.557589172116298,0.0525372789052569,-2.04852811915443,-4.07947298109672,-2.54570527491485,"ENTPD2","ectonucleoside triphosphate diphosphohydrolase 2",TRUE
+"207372_s_at",0.987878312181854,0.94212965399357,-0.0734213234006719,-5.93705821509183,-0.0363016458193353,"ENTPD2","ectonucleoside triphosphate diphosphohydrolase 2",TRUE
+"206191_at",0.77340139236553,0.284731697445652,1.09627429224375,-5.3706848364544,0.801493765516987,"ENTPD3","ectonucleoside triphosphate diphosphohydrolase 3",TRUE
+"1555118_at",0.852994610926182,0.45920065462736,0.753298796726237,-5.66701124635246,0.575135072441499,"ENTPD3","ectonucleoside triphosphate diphosphohydrolase 3",TRUE
+"1556558_s_at",0.66447166133726,0.132378342483206,-1.56234271225396,-4.81597311139021,-1.40565831781241,"ENTPD3-AS1","ENTPD3 antisense RNA 1",TRUE
+"204076_at",0.841967750949524,0.434841086802049,0.795362309495763,-5.63617620954463,0.442531296936329,"ENTPD4","ectonucleoside triphosphate diphosphohydrolase 4",TRUE
+"204077_x_at",0.870433264908839,0.508900227088615,0.671408867894453,-5.72247365009759,0.276193965745023,"ENTPD4","ectonucleoside triphosphate diphosphohydrolase 4",TRUE
+"1555358_a_at",0.947926063538122,0.762829592977151,0.305509917725147,-5.89432477561025,0.22079554966531,"ENTPD4","ectonucleoside triphosphate diphosphohydrolase 4",TRUE
+"226594_at",0.668518995965071,0.134667677946085,-1.55267996764928,-4.82908926894543,-0.479747681665932,"ENTPD5","ectonucleoside triphosphate diphosphohydrolase 5",TRUE
+"1554094_at",0.824246019586314,0.391673266298528,0.873662120383635,-5.57460010764678,0.655101701775068,"ENTPD5","ectonucleoside triphosphate diphosphohydrolase 5",TRUE
+"205757_at",0.912241810302154,0.632066698997014,-0.485530497747499,-5.82551099406541,-0.145786973455609,"ENTPD5","ectonucleoside triphosphate diphosphohydrolase 5",TRUE
+"231676_s_at",0.954723352940649,0.794008925688538,0.264277307159579,-5.90572291359721,0.14656697530245,"ENTPD5","ectonucleoside triphosphate diphosphohydrolase 5",TRUE
+"239953_at",0.603702127972549,0.0777742588218051,1.84947769349463,-4.39825735688259,0.577636915873785,"ENTPD6","ectonucleoside triphosphate diphosphohydrolase 6 (putative)",TRUE
+"234946_at",0.813454382987859,0.364045954884789,0.926741978713033,-5.52980884527283,0.671316635473796,"ENTPD6","ectonucleoside triphosphate diphosphohydrolase 6 (putative)",TRUE
+"201704_at",0.959451355429682,0.816729944497638,-0.234526517587673,-5.91292915164536,-0.160380576968887,"ENTPD6","ectonucleoside triphosphate diphosphohydrolase 6 (putative)",TRUE
+"220153_at",0.843121215318579,0.437483414213068,0.790731150231795,-5.63964846090925,0.215037005163442,"ENTPD7","ectonucleoside triphosphate diphosphohydrolase 7",TRUE
+"235204_at",0.849990777966633,0.452551011562589,-0.764644140232873,-5.65885022165542,-0.27047047370715,"ENTPD7","ectonucleoside triphosphate diphosphohydrolase 7",TRUE
+"226776_at",0.56861088242915,0.0585067103005881,-1.99482126093369,-4.16766203741064,-1.06976284866494,"ENY2","ENY2, transcription and export complex 2 subunit",TRUE
+"226775_at",0.771011793494937,0.279868382393432,-1.10770845853542,-5.35909147160812,-0.418314678830097,"ENY2","ENY2, transcription and export complex 2 subunit",TRUE
+"218482_at",0.920119557710459,0.659881237443391,-0.446061795270963,-5.84323390827642,-0.159287911922677,"ENY2","ENY2, transcription and export complex 2 subunit",TRUE
+"221935_s_at",0.720018659171833,0.195941703258915,1.33341973151065,-5.10890783427443,0.906432499398922,"EOGT","EGF domain specific O-linked N-acetylglucosamine transferase",TRUE
+"231776_at",0.97112136867183,0.861619902847381,0.176351330461787,-5.92454726112632,0.0761797172360978,"EOMES","eomesodermin",TRUE
+"213579_s_at",0.896907177224677,0.581995005463905,0.558662111558772,-5.78880215474359,0.212501215890951,"EP300","E1A binding protein p300",TRUE
+"202221_s_at",0.940069411747533,0.731728700532208,0.347184640495715,-5.88114419248144,0.136829293840576,"EP300","E1A binding protein p300",TRUE
+"1562921_at",0.965682789065794,0.839521432645182,-0.204899321283386,-5.91925541647524,-0.122575375270079,"EP300-AS1","EP300 antisense RNA 1",TRUE
+"212376_s_at",0.932742319779223,0.702997039387854,0.386248168692356,-5.86727975844155,0.0861088419091427,"EP400","E1A binding protein p400",TRUE
+"230629_s_at",0.961899417580562,0.826966393877061,0.221194973044746,-5.91588089552704,0.0978073834412116,"EP400","E1A binding protein p400",TRUE
+"230628_at",0.980174445251813,0.906851839287845,-0.118356270090982,-5.93286290212793,-0.0775168505748445,"EP400","E1A binding protein p400",TRUE
+"212375_at",0.996555192440456,0.982816161184963,0.0217828446608645,-5.93945237567624,0.00663269321990612,"EP400","E1A binding protein p400",TRUE
+"229892_at",0.769258076576208,0.276404524855329,-1.11594062111183,-5.35067860351161,-0.426949208804187,"EP400NL","EP400 N-terminal like",TRUE
+"1562845_at",0.941306621461417,0.737128701355086,0.339905715759103,-5.88356634616551,0.157918064819635,"EP400NL","EP400 N-terminal like",TRUE
+"241437_s_at",0.97922824128613,0.898929485299657,-0.128478362531944,-5.93164687748845,-0.0404024699485039,"EP400NL","EP400 N-terminal like",TRUE
+"200878_at",0.725168361556674,0.203465434161546,1.3104521498496,-5.13617553170065,1.30517154993455,"EPAS1","endothelial PAS domain protein 1",TRUE
+"200879_s_at",0.736020435324742,0.221150545011546,1.25895239520889,-5.19585383211505,1.06869343247493,"EPAS1","endothelial PAS domain protein 1",TRUE
+"241055_at",0.774230543658252,0.287708669663501,1.08934466967605,-5.37765884704413,0.854388606193601,"EPAS1","endothelial PAS domain protein 1",TRUE
+"207793_s_at",0.776983560547865,0.296042436433329,1.07021641099234,-5.3967047847076,0.503011983325814,"EPB41","erythrocyte membrane protein band 4.1",TRUE
+"225051_at",0.892746695408886,0.565573911506614,0.58331226567232,-5.77530381452305,0.185763864105777,"EPB41","erythrocyte membrane protein band 4.1",TRUE
+"1554481_a_at",0.900250794823241,0.595068852670429,0.53928445787377,-5.79901618752609,0.472777813697734,"EPB41","erythrocyte membrane protein band 4.1",TRUE
+"214530_x_at",0.908619002315341,0.619725082168821,0.503293110701683,-5.81705589205812,0.145280778908377,"EPB41","erythrocyte membrane protein band 4.1",TRUE
+"222066_at",0.748438284778152,0.241139861064535,1.20440953341947,-5.25681606936704,0.768034646645143,"EPB41L1","erythrocyte membrane protein band 4.1 like 1",TRUE
+"212336_at",0.827667049362122,0.396491052497685,0.864658986066114,-5.58195444004865,0.493997168842872,"EPB41L1","erythrocyte membrane protein band 4.1 like 1",TRUE
+"230289_at",0.849646596450765,0.450973895702118,-0.767349663989842,-5.65688703457028,-0.586098197088614,"EPB41L1","erythrocyte membrane protein band 4.1 like 1",TRUE
+"212339_at",0.947778780715578,0.762423965737271,0.306049752536458,-5.89416469761905,0.194038144824855,"EPB41L1","erythrocyte membrane protein band 4.1 like 1",TRUE
+"231174_s_at",0.697713925841949,0.168688936203457,1.42291508949515,-4.9988953202302,0.854766729713919,"EPB41L2","erythrocyte membrane protein band 4.1 like 2",TRUE
+"201718_s_at",0.812302873476553,0.359063655600894,0.9365961458691,-5.52122556955443,1.00513072350874,"EPB41L2","erythrocyte membrane protein band 4.1 like 2",TRUE
+"242092_at",0.853297110808539,0.460092148212678,-0.751785282161863,-5.66809123254667,-0.206770352606052,"EPB41L2","erythrocyte membrane protein band 4.1 like 2",TRUE
+"201719_s_at",0.858975609973555,0.475307470024164,0.726218087762267,-5.68602366183094,0.642240440023446,"EPB41L2","erythrocyte membrane protein band 4.1 like 2",TRUE
+"212681_at",0.67090497764287,0.136834738643038,-1.54365753045512,-4.84127827739937,-2.65093207880218,"EPB41L3","erythrocyte membrane protein band 4.1 like 3",TRUE
+"206710_s_at",0.82064687791745,0.381427414898884,-0.893050970017921,-5.55852211585955,-1.45502430451589,"EPB41L3","erythrocyte membrane protein band 4.1 like 3",TRUE
+"211776_s_at",0.974982245454858,0.878188011778908,0.155047042356592,-5.92798146354533,0.155300481895636,"EPB41L3","erythrocyte membrane protein band 4.1 like 3",TRUE
+"220120_s_at",0.818755243760308,0.372396989516806,0.910424980343372,-5.54383758407492,0.996176249956566,"EPB41L4A","erythrocyte membrane protein band 4.1 like 4A",TRUE
+"228256_s_at",0.896907177224677,0.581874119617483,0.558842286091025,-5.78870554174436,0.600132085677741,"EPB41L4A","erythrocyte membrane protein band 4.1 like 4A",TRUE
+"1555038_at",0.928777626237599,0.686586725019568,-0.408833292734787,-5.85859976052472,-0.40358392073257,"EPB41L4A","erythrocyte membrane protein band 4.1 like 4A",TRUE
+"220119_at",0.956734254923335,0.803750952664156,0.251492882856164,-5.90892425258375,0.169932628761178,"EPB41L4A","erythrocyte membrane protein band 4.1 like 4A",TRUE
+"228259_s_at",0.812505689959838,0.361173082556633,-0.932412932516085,-5.52487946782406,-0.519752043770001,"EPB41L4A-AS1","EPB41L4A antisense RNA 1",TRUE
+"225698_at",0.947326616179611,0.760404326468717,-0.308739004073709,-5.89336307757782,-0.143498167330433,"EPB41L4A-AS1","EPB41L4A antisense RNA 1",TRUE
+"220364_at",0.986720888319514,0.937998761868776,0.0786732082107904,-5.93666926591104,0.0897062100740795,"EPB41L4A-AS2","EPB41L4A antisense RNA 2 (head to head)",TRUE
+"220161_s_at",0.696169403206575,0.166257939536511,-1.43144549475249,-4.98810174682138,-0.970036517318698,"EPB41L4B","erythrocyte membrane protein band 4.1 like 4B",TRUE
+"223427_s_at",0.831875452294783,0.40723022754885,-0.844840830268564,-5.59789319710442,-0.551302225249417,"EPB41L4B","erythrocyte membrane protein band 4.1 like 4B",TRUE
+"233098_s_at",0.862800800218883,0.486706338981835,0.707377382980863,-5.69886078276757,0.67892509455252,"EPB41L4B","erythrocyte membrane protein band 4.1 like 4B",TRUE
+"223859_at",0.959573917194453,0.817330951402639,0.233742612175429,-5.91310747091305,0.166480909091939,"EPB41L4B","erythrocyte membrane protein band 4.1 like 4B",TRUE
+"223426_s_at",0.974982245454858,0.878307216289121,0.154894039833316,-5.92800453423276,0.0477090769810573,"EPB41L4B","erythrocyte membrane protein band 4.1 like 4B",TRUE
+"220524_at",0.993007207436969,0.966704498347727,0.0422161744339754,-5.93881547149641,0.0307775278273139,"EPB41L4B","erythrocyte membrane protein band 4.1 like 4B",TRUE
+"225855_at",0.516545992966588,0.0364014944837726,-2.22723633210492,-3.77528461114259,-0.827091859354113,"EPB41L5","erythrocyte membrane protein band 4.1 like 5",TRUE
+"229292_at",0.713330901550199,0.187934456903134,-1.35863511175495,-5.07851365352299,-1.06328239904298,"EPB41L5","erythrocyte membrane protein band 4.1 like 5",TRUE
+"230951_at",0.733012446828677,0.217520792720982,-1.26925641761387,-5.18407673755085,-0.859456727782864,"EPB41L5","erythrocyte membrane protein band 4.1 like 5",TRUE
+"220977_x_at",0.755049574909504,0.249070012077041,-1.18371622522327,-5.27933208353305,-0.610488534626294,"EPB41L5","erythrocyte membrane protein band 4.1 like 5",TRUE
+"210746_s_at",0.979347742195592,0.900489120621906,-0.126484622439072,-5.93189427244551,-0.053975413889054,"EPB42","erythrocyte membrane protein band 4.2",TRUE
+"234969_s_at",0.849935057946582,0.452225588830123,0.765201932005592,-5.65844601190869,0.228193413678776,"EPC1","enhancer of polycomb homolog 1",TRUE
+"238633_at",0.899995753396531,0.594117800439208,0.540686967034799,-5.79828868075013,0.216586116196718,"EPC1","enhancer of polycomb homolog 1",TRUE
+"223875_s_at",0.98539961718117,0.927720231252553,-0.0917511793722816,-5.9355840790969,-0.0666695938336899,"EPC1","enhancer of polycomb homolog 1",TRUE
+"225417_at",0.986720888319514,0.937990666211722,0.0786835029485307,-5.93666847713038,0.0230707322187342,"EPC1","enhancer of polycomb homolog 1",TRUE
+"225838_at",0.856257656023992,0.469878167382816,-0.73528491645742,-5.67973169069907,-0.206981850089194,"EPC2","enhancer of polycomb homolog 2",TRUE
+"201839_s_at",0.865345395265289,0.495172506375697,0.693548614570383,-5.70807838311758,0.454548042943063,"EPCAM","epithelial cell adhesion molecule",TRUE
+"223253_at",0.99783553534859,0.989433476513467,-0.0133938121634355,-5.93959610482412,-0.0195013282399117,"EPDR1","ependymin related 1",TRUE
+"227638_at",0.755868740464627,0.250435523246762,-1.1802029519348,-5.28312103367352,-0.590483481463087,"EPG5","ectopic P-granules autophagy protein 5 homolog",TRUE
+"232030_at",0.773887727472977,0.285492738237402,-1.09449782614732,-5.37247643450518,-0.718100317897351,"EPG5","ectopic P-granules autophagy protein 5 homolog",TRUE
+"232031_s_at",0.801892820429336,0.339492846394397,-0.976223045267096,-5.48587013096996,-0.535484035746334,"EPG5","ectopic P-granules autophagy protein 5 homolog",TRUE
+"234048_s_at",0.905166341446495,0.610861045572799,0.516152315923165,-5.81074989690124,0.231291527070959,"EPG5","ectopic P-granules autophagy protein 5 homolog",TRUE
+"1563471_at",0.927909601142037,0.683648381750698,-0.412899855034178,-5.85698531891094,-0.219628695574301,"EPG5","ectopic P-granules autophagy protein 5 homolog",TRUE
+"228453_at",0.937113154905832,0.719790793695371,-0.363345089084461,-5.87558534633936,-0.198461853732319,"EPG5","ectopic P-granules autophagy protein 5 homolog",TRUE
+"236108_at",0.976433695486417,0.88813064868021,0.142298018702246,-5.92982588258074,0.102420676755801,"EPG5","ectopic P-granules autophagy protein 5 homolog",TRUE
+"215804_at",0.354266150238033,0.00946712108812067,2.84088341826795,-2.62641972577972,1.39913816259949,"EPHA1","EPH receptor A1",TRUE
+"205977_s_at",0.848882452441212,0.449337120367647,0.770163593271632,-5.65483823784125,0.404214708220771,"EPHA1","EPH receptor A1",TRUE
+"241482_at",0.913123070637484,0.635220533469981,0.481016880805967,-5.82761219789347,0.371907125847276,"EPHA1","EPH receptor A1",TRUE
+"238263_at",0.332566035407083,0.00818533728434643,2.90432385142956,-2.50026457086828,1.43755582066355,"EPHA1-AS1","EPHA1 antisense RNA 1",TRUE
+"1562249_at",0.528412182286162,0.0411132221937876,2.16865534336354,-3.87675320556823,1.55585000273225,"EPHA1-AS1","EPHA1 antisense RNA 1",TRUE
+"243717_at",0.769258076576208,0.276191667016452,1.11644894034457,-5.35015731629069,0.55737986848029,"EPHA10","EPH receptor A10",TRUE
+"236073_at",0.937623890519979,0.7237630416554,-0.357957084847519,-5.87746646016466,-0.253110083789218,"EPHA10","EPH receptor A10",TRUE
+"1553371_at",0.985392958586682,0.92763009745691,0.0918659309608384,-5.93557382067149,0.0379985011726145,"EPHA10","EPH receptor A10",TRUE
+"203499_at",0.468735421183467,0.0249534624130136,2.40509735074803,-3.4575120853873,2.80589743712543,"EPHA2","EPH receptor A2",TRUE
+"206070_s_at",0.409854205952965,0.0158065566063624,2.61358466309473,-3.06829434839973,2.52080124320759,"EPHA3","EPH receptor A3",TRUE
+"211164_at",0.724623760403195,0.202018732229727,1.31481641311869,-5.13102493413908,1.49221996786429,"EPHA3","EPH receptor A3",TRUE
+"206071_s_at",0.754682106570676,0.248259650583777,1.18580798281349,-5.27707152478923,1.10807230961946,"EPHA3","EPH receptor A3",TRUE
+"228948_at",0.485255613602953,0.0280514659246511,2.3505555541937,-3.55644562240283,3.14646461127501,"EPHA4","EPH receptor A4",TRUE
+"206114_at",0.485255613602953,0.0280636168305905,2.35035279290424,-3.55681102798234,2.98948892722429,"EPHA4","EPH receptor A4",TRUE
+"227449_at",0.540483367247649,0.0449467186804782,2.1253205612889,-3.9507303391989,2.79916153329743,"EPHA4","EPH receptor A4",TRUE
+"229374_at",0.597654932724127,0.0742333271930077,1.8736184691164,-4.36079979765867,1.84970181783924,"EPHA4","EPH receptor A4",TRUE
+"238671_at",0.968980656821882,0.853598990443651,-0.186694573575679,-5.92272120672404,-0.0698289882045315,"EPHA4","EPH receptor A4",TRUE
+"215664_s_at",0.944963505981344,0.752276300027506,-0.319585641460721,-5.89005936564468,-0.250325830885867,"EPHA5","EPH receptor A5",TRUE
+"216837_at",0.956734254923335,0.803771920944047,0.251465413186045,-5.90893096144228,0.090975617251595,"EPHA5","EPH receptor A5",TRUE
+"237939_at",0.986249924471866,0.932514057323015,-0.0856498181398987,-5.9361110700883,-0.091271637671118,"EPHA5","EPH receptor A5",TRUE
+"238241_at",0.505067985736837,0.0329044749006788,-2.27536077504754,-3.69070884103921,-0.990246398768055,"EPHA5-AS1","EPHA5 antisense RNA 1",TRUE
+"233095_at",0.890405697398587,0.558986627731052,0.593303216261025,-5.76967218727623,0.419585665692496,"EPHA6","EPH receptor A6",TRUE
+"1561396_at",0.924696623416105,0.674369948653391,-0.425787890003764,-5.85176491521541,-0.467550235030457,"EPHA6","EPH receptor A6",TRUE
+"233184_at",0.996448610597071,0.982542981152434,0.0221291959974652,-5.93944496810815,0.0182927471845664,"EPHA6","EPH receptor A6",TRUE
+"206852_at",0.614178202960275,0.0851261457429775,-1.80226206425247,-4.47051310829017,-1.9148517215177,"EPHA7","EPH receptor A7",TRUE
+"229288_at",0.734730148360473,0.219381909771285,-1.26395679792239,-5.1901442556284,-0.889581098811623,"EPHA7","EPH receptor A7",TRUE
+"238533_at",0.855872742110607,0.469254635395513,-0.736330147801198,-5.67900158305544,-0.74430420374529,"EPHA7","EPH receptor A7",TRUE
+"1554629_at",0.94630837494651,0.756803738025627,0.313539153634684,-5.8919149654844,0.274626582303003,"EPHA7","EPH receptor A7",TRUE
+"231796_at",0.820536502908875,0.380181858279293,0.895431131163618,-5.55652586741252,0.303078468478215,"EPHA8","EPH receptor A8",TRUE
+"1554069_at",0.896229101808264,0.580097374030719,-0.561492602061299,-5.7872808999351,-0.354429747048436,"EPHA8","EPH receptor A8",TRUE
+"230425_at",0.645740804644555,0.116847470879609,-1.63183430167565,-4.71977827657475,-1.88924344459573,"EPHB1","EPH receptor B1",TRUE
+"211898_s_at",0.812302873476553,0.357396733710258,-0.939913516795575,-5.51831727665099,-0.600898284112562,"EPHB1","EPH receptor B1",TRUE
+"210753_s_at",0.991059530537351,0.958246715300708,-0.0529494192496551,-5.9383180228448,-0.0358023558533613,"EPHB1","EPH receptor B1",TRUE
+"211165_x_at",0.0723378272955723,0.00021857142879165,4.40974645252667,0.684347782360842,4.50780163789161,"EPHB2","EPH receptor B2",TRUE
+"209588_at",0.135512074559804,0.000872432560494761,3.84417626597646,-0.536220122611788,2.08099876371361,"EPHB2","EPH receptor B2",TRUE
+"210651_s_at",0.171054203824867,0.00146605568806497,3.63044696114365,-0.993793379659274,1.86316084264174,"EPHB2","EPH receptor B2",TRUE
+"209589_s_at",0.195828721931222,0.00211782151097113,3.47790723259724,-1.31757893272677,3.72695704660805,"EPHB2","EPH receptor B2",TRUE
+"230088_at",0.56861088242915,0.0585929539714639,1.99408171316154,-4.16886549400028,1.3677070892304,"EPHB2","EPH receptor B2",TRUE
+"230119_at",0.676294804179428,0.142912049670127,1.51896815991073,-4.87434458315114,0.93945263356585,"EPHB2","EPH receptor B2",TRUE
+"204600_at",0.782206338814045,0.304238263913138,-1.05177687634551,-5.41477895243053,-0.921020496506403,"EPHB3","EPH receptor B3",TRUE
+"1438_at",0.813065886130395,0.362506247757798,-0.929777568824812,-5.52717365129909,-0.786167073508272,"EPHB3","EPH receptor B3",TRUE
+"202894_at",0.925504446660705,0.677311160311464,0.421694616357831,-5.85344002143347,0.224307496818479,"EPHB4","EPH receptor B4",TRUE
+"216680_s_at",0.959873464297573,0.81856534332581,0.232133038859428,-5.91347174771931,0.101084907588868,"EPHB4","EPH receptor B4",TRUE
+"204718_at",0.545083406296189,0.0468773040065886,2.10474480808406,-3.98552425464464,1.03225224046348,"EPHB6","EPH receptor B6",TRUE
+"202017_at",0.470726957161354,0.0253217412067718,-2.39829605492713,-3.46991790629341,-1.55233080864808,"EPHX1","epoxide hydrolase 1",TRUE
+"209368_at",0.87825462101175,0.530488748976765,-0.637255491854498,-5.74380210734025,-0.765875425342493,"EPHX2","epoxide hydrolase 2",TRUE
+"220013_at",0.64513208805899,0.11567817296527,1.6373729677789,-4.71197204001977,1.00900703993333,"EPHX3","epoxide hydrolase 3",TRUE
+"239579_at",0.638865555358241,0.10975875722573,1.66615650724946,-4.67107862284315,1.83762883873311,"EPHX4","epoxide hydrolase 4",TRUE
+"210870_s_at",0.806089660856733,0.346519532546213,0.961821081545448,-5.49887466995268,0.554635284658646,"EPM2A","epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)",TRUE
+"216079_at",0.930827859648584,0.693740724686571,-0.39896150118929,-5.86245346800165,-0.199968045515821,"EPM2A","epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)",TRUE
+"205231_s_at",0.955904644595647,0.800494088543817,0.255761981148809,-5.90787276816675,0.117050988259142,"EPM2A","epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)",TRUE
+"236314_at",0.835952408568777,0.416928407834331,0.82722815110072,-5.6117685831632,0.597656482556578,"EPM2AIP1","EPM2A interacting protein 1",TRUE
+"227847_at",0.92051722798026,0.661748249637481,-0.443438800238935,-5.84435956426127,-0.336874812661893,"EPM2AIP1","EPM2A interacting protein 1",TRUE
+"202909_at",0.991399575197268,0.960065104830687,0.05064132072967,-5.93843446342262,0.0621886666140092,"EPM2AIP1","EPM2A interacting protein 1",TRUE
+"221141_x_at",0.773107052530371,0.283937981817662,-1.09813069102165,-5.36880986278159,-0.415205878993985,"EPN1","epsin 1",TRUE
+"226667_x_at",0.836756831475262,0.418735856267691,0.823974400340302,-5.61430198529575,0.291879313361795,"EPN1","epsin 1",TRUE
+"1561545_at",0.812204391961413,0.356419203956656,0.941863760831268,-5.51660311943827,0.682621201418847,"EPN2-AS1","EPN2 antisense RNA 1",TRUE
+"203463_s_at",0.942049201741017,0.739442466037218,0.336792623601923,-5.8845867726648,0.165158635106398,"EPN2-IT1///EPN2","EPN2 intronic transcript 1///epsin 2",TRUE
+"203464_s_at",0.982462634157412,0.915276026217503,0.107606856485288,-5.93404523529269,0.037521197458414,"EPN2-IT1///EPN2","EPN2 intronic transcript 1///epsin 2",TRUE
+"241239_at",0.989586772349659,0.94946747868955,-0.0640973647857565,-5.93768259353848,-0.0542646973870169,"EPN2-IT1///EPN2","EPN2 intronic transcript 1///epsin 2",TRUE
+"223895_s_at",0.7768734672127,0.294830534348241,-1.07297384493891,-5.39397781478487,-1.25585147804615,"EPN3","epsin 3",TRUE
+"220318_at",0.998870448604467,0.99568673019797,-0.00546723065452383,-5.93966892214501,-0.00682659474933445,"EPN3","epsin 3",TRUE
+"217254_s_at",0.627092759817312,0.0985879068094406,1.72425480617413,-4.58689748564398,1.03164153146755,"EPO","erythropoietin",TRUE
+"207257_at",0.985868869736215,0.931485347830811,-0.0869588234586681,-5.93600105980015,-0.0586255946949228,"EPO","erythropoietin",TRUE
+"209962_at",0.753523115318527,0.246779572328152,1.18964167377881,-5.27291942950948,0.614391644144904,"EPOR","erythropoietin receptor",TRUE
+"209963_s_at",0.760317850062887,0.258905433289568,1.15872391432333,-5.30607114710894,0.46366552623055,"EPOR","erythropoietin receptor",TRUE
+"396_f_at",0.797127506889432,0.330332595626328,0.995308356224519,-5.46836548621252,0.308771249527,"EPOR","erythropoietin receptor",TRUE
+"37986_at",0.858826390511142,0.474859028042987,-0.726964662490801,-5.68550837429598,-0.39216076761786,"EPOR","erythropoietin receptor",TRUE
+"216999_at",0.896621712710656,0.581397888993706,0.559552266925628,-5.78832454233071,0.405349515664664,"EPOR","erythropoietin receptor",TRUE
+"206319_s_at",0.82064687791745,0.381554708419791,0.892808009493503,-5.55872561097857,0.393978150002329,"EPPIN-WFDC6///EPPIN","EPPIN-WFDC6 readthrough///epididymal peptidase inhibitor",TRUE
+"206318_at",0.828607509614823,0.399105992773397,0.859801922139042,-5.58589257330348,0.51774355690393,"EPPIN-WFDC6///EPPIN","EPPIN-WFDC6 readthrough///epididymal peptidase inhibitor",TRUE
+"208156_x_at",0.62110896023334,0.091771012409631,1.76252823307059,-4.5302677088749,0.84230016694914,"EPPK1","epiplakin 1",TRUE
+"232164_s_at",0.792778640449105,0.324562115348093,1.00751960511776,-5.45700412623953,1.28635327670093,"EPPK1","epiplakin 1",TRUE
+"232165_at",0.846615322073696,0.445010608572901,0.777631779217639,-5.64936639865337,1.10257240782108,"EPPK1","epiplakin 1",TRUE
+"234552_at",0.997654912087849,0.988441540345478,-0.0146512510621218,-5.93957892872862,-0.0122753531305655,"EPPK1","epiplakin 1",TRUE
+"234555_at",0.998870448604467,0.995362637138341,-0.00587803549047398,-5.93966665209818,-0.00350285781041748,"EPPK1","epiplakin 1",TRUE
+"200843_s_at",0.682504456039784,0.149994632863494,-1.49125830501635,-4.91094887861026,-0.523258771838444,"EPRS","glutamyl-prolyl-tRNA synthetase",TRUE
+"200842_s_at",0.794867651585671,0.327047877276109,-1.00224101935878,-5.46193075065217,-0.383711647158387,"EPRS","glutamyl-prolyl-tRNA synthetase",TRUE
+"200841_s_at",0.856857560656867,0.471301343995104,-0.732902298686752,-5.68139230048307,-0.308974693181286,"EPRS","glutamyl-prolyl-tRNA synthetase",TRUE
+"217887_s_at",0.88379975017027,0.542036886548663,0.619297056326456,-5.75458756218431,0.188893744747578,"EPS15","epidermal growth factor receptor pathway substrate 15",TRUE
+"217886_at",0.961212424803935,0.823083972849131,0.226246326153178,-5.91478269326655,0.0755581489165262,"EPS15","epidermal growth factor receptor pathway substrate 15",TRUE
+"232438_at",0.629044710648574,0.100022274649787,-1.71649087596805,-4.59827228924364,-1.58432900537422,"EPS15L1","epidermal growth factor receptor pathway substrate 15 like 1",TRUE
+"222112_at",0.632216562924782,0.103168193171022,-1.69978928249405,-4.6226112141709,-1.31534765276086,"EPS15L1","epidermal growth factor receptor pathway substrate 15 like 1",TRUE
+"221056_x_at",0.643515428391208,0.114133702366308,-1.64476127645639,-4.70152731045026,-0.527850064165257,"EPS15L1","epidermal growth factor receptor pathway substrate 15 like 1",TRUE
+"222113_s_at",0.710842845257879,0.18457861681072,-1.36945506186563,-5.06532565913307,-0.464401024663607,"EPS15L1","epidermal growth factor receptor pathway substrate 15 like 1",TRUE
+"231926_at",0.725181883744124,0.203705820267685,-1.30972931917295,-5.13702720129877,-0.822891757831306,"EPS15L1","epidermal growth factor receptor pathway substrate 15 like 1",TRUE
+"243482_at",0.856063712917985,0.469453284031457,-0.735997062568921,-5.67923435425361,-0.36618944449441,"EPS15L1","epidermal growth factor receptor pathway substrate 15 like 1",TRUE
+"202609_at",0.581128536542197,0.0636770198888761,1.95210194408757,-4.23668330790341,0.993109708443969,"EPS8","epidermal growth factor receptor pathway substrate 8",TRUE
+"221665_s_at",0.789661545166663,0.317423179044583,-1.02283769233929,-5.44257479703008,-0.865938879019451,"EPS8L1","EPS8 like 1",TRUE
+"218778_x_at",0.822862741321714,0.388649961909751,-0.879348567642447,-5.56991860424268,-0.484357298094454,"EPS8L1","EPS8 like 1",TRUE
+"218779_x_at",0.863488263044072,0.488228187722807,-0.704881432690244,-5.70053729571113,-0.513280771706974,"EPS8L1","EPS8 like 1",TRUE
+"91826_at",0.888972420461865,0.556471417333831,-0.597134119354507,-5.76748829123993,-0.589847292206816,"EPS8L1","EPS8 like 1",TRUE
+"221655_x_at",0.92575089465436,0.678716233972376,-0.419741767372951,-5.85423358894486,-0.382762111858323,"EPS8L1","EPS8 like 1",TRUE
+"222546_s_at",0.690381347688918,0.160199480523625,1.45314987137779,-4.9604016121361,0.747073336373171,"EPS8L2","EPS8 like 2",TRUE
+"229020_x_at",0.804212866894346,0.34285276593495,0.969311372456592,-5.49213318348223,0.465554350499353,"EPS8L2","EPS8 like 2",TRUE
+"218180_s_at",0.821561540371535,0.384116646666988,0.887929382228792,-5.56280092423695,0.368509072807406,"EPS8L2","EPS8 like 2",TRUE
+"219404_at",0.982243328340126,0.914426692671002,-0.108690011237181,-5.93393118898732,-0.0579219409855982,"EPS8L3","EPS8 like 3",TRUE
+"227609_at",0.00524813371699095,1.43981720630753e-06,6.51465586128013,5.03308600982849,3.24940425008821,"EPSTI1","epithelial stromal interaction 1 (breast)",TRUE
+"235276_at",0.499527011501001,0.0316298585060167,2.29407092373612,-3.65753827125132,2.30852720605576,"EPSTI1","epithelial stromal interaction 1 (breast)",TRUE
+"1555274_a_at",0.766550448794594,0.267837771196836,1.13662867657517,-5.32929323608329,0.457352012208686,"EPT1","ethanolaminephosphotransferase 1",TRUE
+"224888_at",0.772704859424721,0.283241860978979,1.09976192124815,-5.36715998193702,0.323470979823831,"EPT1","ethanolaminephosphotransferase 1",TRUE
+"1570371_a_at",0.7974001826642,0.330683970723163,0.994569581606355,-5.46904880808827,0.703365343227074,"EPT1","ethanolaminephosphotransferase 1",TRUE
+"214627_at",0.67818193964437,0.145573822751262,-1.5084252400392,-4.8883351830453,-0.791808928141738,"EPX","eosinophil peroxidase",TRUE
+"206439_at",0.982243328340126,0.914760066740983,0.1082648436038,-5.93397609128488,0.0939601731991275,"EPYC","epiphycan",TRUE
+"232868_at",0.703463984269897,0.175149124392999,1.40071533506892,-5.02673616733469,0.483397742447707,"EQTN","equatorin",TRUE
+"1554981_at",0.724623760403195,0.202019375353014,-1.31481446761073,-5.13102723340404,-1.26526542210659,"EQTN","equatorin",TRUE
+"1554982_a_at",0.959451355429682,0.816840133164303,-0.234382785056329,-5.91296189173578,-0.134755662995967,"EQTN","equatorin",TRUE
+"212087_s_at",0.955959857580254,0.801072021188849,-0.255004074624537,-5.90806072563082,-0.074692422245624,"ERAL1","Era like 12S mitochondrial rRNA chaperone 1",TRUE
+"209701_at",0.407748633394319,0.0156916999776662,2.61686459863604,-3.06204057897151,0.841096316932529,"ERAP1","endoplasmic reticulum aminopeptidase 1",TRUE
+"209788_s_at",0.645299061556945,0.116478398509474,1.63357745832563,-4.71732365125832,1.23635853093551,"ERAP1","endoplasmic reticulum aminopeptidase 1",TRUE
+"210385_s_at",0.748760747870936,0.241843404429233,1.20255320040569,-5.2588497651218,0.745498785230691,"ERAP1","endoplasmic reticulum aminopeptidase 1",TRUE
+"214034_at",0.851319596585235,0.455055298539964,0.760359733496856,-5.66194567337452,0.446881700544915,"ERAP1","endoplasmic reticulum aminopeptidase 1",TRUE
+"214012_at",0.9037138034254,0.605285770122326,0.52428571350106,-5.80668133925367,0.578097145661062,"ERAP1","endoplasmic reticulum aminopeptidase 1",TRUE
+"219759_at",0.85334340854827,0.461492230158054,0.749411858006317,-5.66978067587445,1.16467166984092,"ERAP2","endoplasmic reticulum aminopeptidase 2",TRUE
+"227462_at",0.871708868449496,0.513288603748125,0.664402417166411,-5.72693614218229,0.939815291053419,"ERAP2","endoplasmic reticulum aminopeptidase 2",TRUE
+"1554272_at",0.884815577925557,0.544920167167981,0.614845335586822,-5.75721523559258,0.553817692146507,"ERAP2","endoplasmic reticulum aminopeptidase 2",TRUE
+"235104_at",0.936992192746977,0.718841251685933,0.364634677644599,-5.87513099672551,0.322629029080439,"ERAP2","endoplasmic reticulum aminopeptidase 2",TRUE
+"1554273_a_at",0.989951606190912,0.950987255820124,-0.0621669841903248,-5.93780128664592,-0.0659477300104827,"ERAP2","endoplasmic reticulum aminopeptidase 2",TRUE
+"216836_s_at",0.753827379204375,0.247001691786857,-1.18906524573452,-5.27354447843624,-1.21546240674501,"ERBB2","erb-b2 receptor tyrosine kinase 2",TRUE
+"234354_x_at",0.888756025960104,0.555540400872313,-0.598554431313659,-5.76667515833405,-0.691361141533531,"ERBB2","erb-b2 receptor tyrosine kinase 2",TRUE
+"210930_s_at",0.897949253801113,0.586775142931983,-0.551552427895519,-5.79259036201946,-0.752686807086365,"ERBB2","erb-b2 receptor tyrosine kinase 2",TRUE
+"1563252_at",0.682744111897512,0.150644456171347,1.4887698190014,-4.9142096634955,0.963957916248327,"ERBB3","erb-b2 receptor tyrosine kinase 3",TRUE
+"215638_at",0.77547560202111,0.292405949773789,1.07851495654709,-5.38847895614576,0.34157886354277,"ERBB3","erb-b2 receptor tyrosine kinase 3",TRUE
+"226213_at",0.851124330077654,0.454221764776049,-0.761784185635904,-5.66091834197102,-0.764185412760115,"ERBB3","erb-b2 receptor tyrosine kinase 3",TRUE
+"202454_s_at",0.855395723404557,0.467919338038069,-0.738571282575623,-5.6774328044328,-0.674510148228839,"ERBB3","erb-b2 receptor tyrosine kinase 3",TRUE
+"1563253_s_at",0.885029460971826,0.545509438322095,-0.613937055945344,-5.75774911214667,-0.406716434815987,"ERBB3","erb-b2 receptor tyrosine kinase 3",TRUE
+"214053_at",0.563790680098225,0.0557626897716152,-2.01887228280834,-4.12836156575135,-1.82290093908067,"ERBB4","erb-b2 receptor tyrosine kinase 4",TRUE
+"233494_at",0.635368778245437,0.106256222633051,1.68381065702999,-4.64572894183392,1.01298385263675,"ERBB4","erb-b2 receptor tyrosine kinase 4",TRUE
+"206794_at",0.724853010944214,0.202424555210314,-1.31358971852996,-5.13247411149284,-0.887060535866607,"ERBB4","erb-b2 receptor tyrosine kinase 4",TRUE
+"233498_at",0.902521078772712,0.601645089870534,-0.529616214499417,-5.80398127060273,-0.397907220074401,"ERBB4","erb-b2 receptor tyrosine kinase 4",TRUE
+"217941_s_at",0.813660971341375,0.364555619292317,0.92573904738451,-5.53067774681899,0.302490345877628,"ERBIN","erbb2 interacting protein",TRUE
+"232896_at",0.884729701742031,0.544051877749469,0.616184633923858,-5.75642662289609,0.249694747931255,"ERBIN","erbb2 interacting protein",TRUE
+"222473_s_at",0.932091525948902,0.700565868724178,0.389580968731146,-5.86602943991344,0.127420149116208,"ERBIN","erbb2 interacting protein",TRUE
+"1555294_a_at",0.460687961482278,0.0230954860982702,2.44089434607251,-3.39190035200938,1.01563263082461,"ERC1","ELKS/RAB6-interacting/CAST family member 1",TRUE
+"1552663_a_at",0.523369751179323,0.0388252569651522,2.19629475601545,-3.82908533822356,0.68943445444414,"ERC1","ELKS/RAB6-interacting/CAST family member 1",TRUE
+"1563947_a_at",0.703902004301726,0.175679830093021,1.39892085957114,-5.0289708678473,0.608605250359312,"ERC1","ELKS/RAB6-interacting/CAST family member 1",TRUE
+"215606_s_at",0.769258076576208,0.275956224339131,1.11701152641275,-5.3495801326374,0.484312864390064,"ERC1","ELKS/RAB6-interacting/CAST family member 1",TRUE
+"226049_at",0.833947935066508,0.411721326483656,0.836651946763122,-5.60437843251178,0.260136032117266,"ERC1","ELKS/RAB6-interacting/CAST family member 1",TRUE
+"235820_at",0.84421131646729,0.440874880674724,-0.784812126428209,-5.64405850646283,-0.459030068509967,"ERC1","ELKS/RAB6-interacting/CAST family member 1",TRUE
+"213938_at",0.83030603167465,0.402609494583325,0.853326389868155,-5.59111083900932,0.615139342576125,"ERC2","ELKS/RAB6-interacting/CAST family member 2",TRUE
+"208247_at",0.724590981430178,0.201878270144049,1.31524143968701,-5.13052255494402,0.557200884732187,"ERC2-IT1","ERC2 intronic transcript 1",TRUE
+"203719_at",0.764430688544079,0.26446633949597,-1.14490356969935,-5.32064240629001,-0.342472354185308,"ERCC1","ERCC excision repair 1, endonuclease non-catalytic subunit",TRUE
+"203720_s_at",0.86481525165637,0.492446782071229,-0.69798593941281,-5.70513958529177,-0.201860386686073,"ERCC1","ERCC excision repair 1, endonuclease non-catalytic subunit",TRUE
+"228131_at",0.892278517390981,0.564500216986158,0.584936631978649,-5.77439450117438,0.275302020231109,"ERCC1","ERCC excision repair 1, endonuclease non-catalytic subunit",TRUE
+"235399_at",0.612420348961838,0.0843406131308555,-1.80713452638003,-4.46311890928167,-0.529742619563573,"ERCC2","ERCC excision repair 2, TFIIH core complex helicase subunit",TRUE
+"213468_at",0.994587495898891,0.974944600605174,0.0317640712023155,-5.93919206732312,0.0147359821269681,"ERCC2","ERCC excision repair 2, TFIIH core complex helicase subunit",TRUE
+"202176_at",0.992342196993659,0.964186550139081,-0.0454109557245371,-5.93867913104041,-0.0114314493643786,"ERCC3","ERCC excision repair 3, TFIIH core complex helicase subunit",TRUE
+"235215_at",0.480603497646452,0.0271383286834553,-2.36602938714016,-3.52850692423775,-0.823588672295108,"ERCC4","ERCC excision repair 4, endonuclease catalytic subunit",TRUE
+"210158_at",0.952369155692131,0.781953247150581,-0.280160726988451,-5.90152602270353,-0.098717694189487,"ERCC4","ERCC excision repair 4, endonuclease catalytic subunit",TRUE
+"202414_at",0.782257848574678,0.304354884245203,1.05151706094684,-5.41503160609996,0.47123050983414,"ERCC5","ERCC excision repair 5, endonuclease",TRUE
+"207347_at",0.603002136983408,0.0774021748240517,1.85196887157582,-4.39440792153103,0.536817145715595,"ERCC6","ERCC excision repair 6, chromatin remodeling factor",TRUE
+"230108_at",0.984004604128855,0.921541738932164,0.0996201808568625,-5.93485093408085,0.0342679308855569,"ERCC6","ERCC excision repair 6, chromatin remodeling factor",TRUE
+"232287_at",0.762554575628173,0.262037043747638,1.15091436113678,-5.31432390929367,0.468796868057407,"ERCC6-PGBD3///PGBD3///ERCC6","ERCC6-PGBD3 readthrough///piggyBac transposable element derived 3///ERCC excision repair 6, chromatin remodeling factor",TRUE
+"219650_at",0.87825462101175,0.530420992826811,0.637361478246778,-5.74373757380587,0.179962156594948,"ERCC6L","ERCC excision repair 6 like, spindle assembly checkpoint helicase",TRUE
+"229710_at",0.441225789932205,0.0204089624643539,-2.49769331868063,-3.28672885930981,-0.763473804169664,"ERCC6L2","ERCC excision repair 6 like 2",TRUE
+"232801_at",0.771159692311272,0.280317104038641,-1.10664746072588,-5.36017173897042,-1.03789193647565,"ERCC6L2","ERCC excision repair 6 like 2",TRUE
+"228211_at",0.868313695469383,0.502659756689277,0.681430943552145,-5.71601260182902,0.219644060049283,"ERCC6L2","ERCC excision repair 6 like 2",TRUE
+"232013_at",0.896627699387688,0.581418170170847,0.559522025131829,-5.7883407806566,0.266562170108553,"ERCC6L2","ERCC excision repair 6 like 2",TRUE
+"220716_at",0.55937703282623,0.0532917870421374,-2.04144824542327,-4.09118708954727,-0.731534166239444,"ERCC8","ERCC excision repair 8, CSA ubiquitin ligase complex subunit",TRUE
+"1554882_at",0.677509122383198,0.145092900118607,-1.51031835829866,-4.88582872408812,-1.17592757832619,"ERCC8","ERCC excision repair 8, CSA ubiquitin ligase complex subunit",TRUE
+"205162_at",0.912329443373872,0.632776075997803,-0.484514382637834,-5.82598569498931,-0.166941643880847,"ERCC8","ERCC excision repair 8, CSA ubiquitin ligase complex subunit",TRUE
+"1554883_a_at",0.98242523732786,0.915133376078792,0.107788768903034,-5.93402616129409,0.0444685824492677,"ERCC8","ERCC excision repair 8, CSA ubiquitin ligase complex subunit",TRUE
+"205767_at",0.0595361125571683,0.000131758017730542,4.61633646716388,1.12970704100694,5.80726164062219,"EREG","epiregulin",TRUE
+"1569583_at",0.0723378272955723,0.000226868493903731,4.39454893068043,0.65153303138215,2.72457606493179,"EREG","epiregulin",TRUE
+"203643_at",0.16767133696705,0.00138200482526202,-3.65483879449085,-0.94177644055576,-1.23508899279518,"ERF","ETS2 repressor factor",TRUE
+"230368_at",0.595936234743389,0.0723586494358479,-1.88680906471064,-4.34018813970293,-1.07539535857644,"ERF","ETS2 repressor factor",TRUE
+"229622_at",0.60210191384251,0.0770646400195681,-1.85423776880212,-4.39089875493723,-2.1612520067669,"ERFE","erythroferrone",TRUE
+"241926_s_at",0.710739561811938,0.183965236607679,1.37144950878473,-5.06288519872226,1.29995986438745,"ERG","ERG, ETS transcription factor",TRUE
+"211626_x_at",0.823074246722209,0.389844997513129,0.877097435620231,-5.5717752735869,0.544075235416519,"ERG","ERG, ETS transcription factor",TRUE
+"213541_s_at",0.885029460971826,0.5455823154821,0.613824762096975,-5.75781506434798,0.57255842521186,"ERG","ERG, ETS transcription factor",TRUE
+"222079_at",0.9802233499944,0.907323834926025,-0.117753629373118,-5.93293215954186,-0.057886381242847,"ERG","ERG, ETS transcription factor",TRUE
+"224577_at",0.68033297785336,0.147871682561588,-1.49944984915329,-4.90018419854019,-0.846667920114351,"ERGIC1","endoplasmic reticulum-golgi intermediate compartment 1",TRUE
+"224576_at",0.726606584292858,0.205654437945952,-1.30389425425544,-5.14388775666872,-0.778629194487197,"ERGIC1","endoplasmic reticulum-golgi intermediate compartment 1",TRUE
+"223847_s_at",0.748438284778152,0.241133196643299,-1.20442713728623,-5.25679677050632,-0.589538699176483,"ERGIC1","endoplasmic reticulum-golgi intermediate compartment 1",TRUE
+"224024_at",0.877861946695164,0.529363851700537,-0.639016046193583,-5.74272879422611,-0.489155596534674,"ERGIC1","endoplasmic reticulum-golgi intermediate compartment 1",TRUE
+"218135_at",0.860085676417428,0.479446849937578,0.719346158197597,-5.69074304278816,0.251317796177165,"ERGIC2","ERGIC and golgi 2",TRUE
+"240172_at",0.88767000285873,0.552199930313102,-0.603660751853272,-5.76373636387653,-0.268465606011503,"ERGIC2","ERGIC and golgi 2",TRUE
+"226422_at",0.918041148686074,0.651853719469044,0.45737637476304,-5.83830366284525,0.160736743457983,"ERGIC2","ERGIC and golgi 2",TRUE
+"226418_at",0.983935461205724,0.921407429260319,0.0997913089983056,-5.93483432105215,0.0472606899908445,"ERGIC2","ERGIC and golgi 2",TRUE
+"215257_at",0.748184017928985,0.240687373273428,1.20560559868091,-5.25550428368668,0.712020021908104,"ERGIC3","ERGIC and golgi 3",TRUE
+"1558020_at",0.843948499994586,0.440041771154013,0.786263531166411,-5.64298000649422,0.654265181131166,"ERGIC3","ERGIC and golgi 3",TRUE
+"216032_s_at",0.916008366263392,0.645496421666853,-0.46637996478801,-5.83429395718694,-0.203852718016194,"ERGIC3","ERGIC and golgi 3",TRUE
+"200043_at",0.608420686376783,0.0811895258857797,-1.82708331801184,-4.43269552822909,-0.405763086908905,"ERH","enhancer of rudimentary homolog (Drosophila)",TRUE
+"231852_at",0.830635993561085,0.404411507527286,0.850009788134004,-5.59376926448922,0.453419789222651,"ERI1","exoribonuclease 1",TRUE
+"226416_at",0.8920930097751,0.563771728649781,0.586039649215851,-5.77377564217743,0.238967812844701,"ERI1","exoribonuclease 1",TRUE
+"213365_at",0.407748633394319,0.0156984156066766,-2.6166722021222,-3.06240752194942,-0.883933715711027,"ERI2","ERI1 exoribonuclease family member 2",TRUE
+"240603_s_at",0.768852835478002,0.272142536776883,-1.12617343914775,-5.34014427707199,-0.991828916375445,"ERI2","ERI1 exoribonuclease family member 2",TRUE
+"240604_at",0.916743912187819,0.648150940457839,-0.462615757897837,-5.8359796426867,-0.349118494211595,"ERI2","ERI1 exoribonuclease family member 2",TRUE
+"208973_at",0.96820875250691,0.850483246658036,-0.190717996404528,-5.92198287358958,-0.0639464579923565,"ERI3","ERI1 exoribonuclease family member 3",TRUE
+"1556766_at",0.609539262323192,0.0818327871693085,1.82295716142159,-4.43900794288713,0.973416476581324,"ERICH1","glutamate rich 1",TRUE
+"227017_at",0.717996777972856,0.194000299972437,1.3394579464405,-5.10167294900227,0.531535888827007,"ERICH1","glutamate rich 1",TRUE
+"1558371_a_at",0.756807034070535,0.252293316339518,1.17544598318302,-5.28823559099111,1.05875972109653,"ERICH1","glutamate rich 1",TRUE
+"217611_at",0.778955753047799,0.299950390543475,1.06137925594071,-5.40540197341403,0.373431961121853,"ERICH1","glutamate rich 1",TRUE
+"227016_at",0.819018525257656,0.374631843139357,0.906099594338774,-5.54751784222478,0.718738073779237,"ERICH1","glutamate rich 1",TRUE
+"1556357_s_at",0.853956748395465,0.46283128166809,0.747145911716255,-5.67138889317508,0.707137100882561,"ERICH1","glutamate rich 1",TRUE
+"1563315_s_at",0.864599727589179,0.491924432114205,-0.698837900030405,-5.7045732936889,-0.231246316763283,"ERICH1","glutamate rich 1",TRUE
+"242003_at",0.87825462101175,0.530602155752815,0.63707811369233,-5.74391008717246,0.666306293625013,"ERICH1","glutamate rich 1",TRUE
+"236467_at",0.934781502857546,0.710365553950218,0.376173916280181,-5.87099477201883,0.106754044550756,"ERICH1","glutamate rich 1",TRUE
+"1556356_at",0.980009054680439,0.905930848996638,-0.119532313525564,-5.93272673065018,-0.0572798952612494,"ERICH1","glutamate rich 1",TRUE
+"1554978_at",0.663819586595936,0.131926148488895,1.56426764417312,-4.81335256897744,1.25122000868242,"ERICH1-AS1","ERICH1 antisense RNA 1",TRUE
+"1557679_at",0.86921531641038,0.506258552738108,0.675642860588263,-5.71975524639769,0.397860306592091,"ERICH1-AS1","ERICH1 antisense RNA 1",TRUE
+"243753_at",0.960614707352139,0.820963918949127,-0.229007227428584,-5.91417202405066,-0.230726060780931,"ERICH3","glutamate rich 3",TRUE
+"229973_at",0.995025131654789,0.976789828830498,-0.0294240428426716,-5.93926180280769,-0.0374188754490121,"ERICH3","glutamate rich 3",TRUE
+"231687_at",0.87825462101175,0.530568723314759,-0.637130402824346,-5.74387825890948,-0.449853373165415,"ERICH3-AS1","ERICH3 antisense RNA 1",TRUE
+"231632_at",0.878114621305798,0.530020083502201,0.637988744212732,-5.74335542965964,0.273960631812828,"ERICH4","glutamate rich 4",TRUE
+"1552390_a_at",0.124990103243763,0.000733823925765853,3.91512283624181,-0.383603537993423,3.54560439241317,"ERICH5","glutamate rich 5",TRUE
+"1552389_at",0.587626678796111,0.0665710624252776,1.9295107620853,-4.27277108996386,2.01844908028149,"ERICH5","glutamate rich 5",TRUE
+"240729_at",0.793474895845165,0.325212234860435,1.00613635193861,-5.45829741637046,0.551507866503762,"ERICH6","glutamate rich 6",TRUE
+"224628_at",0.851319596585235,0.454572317018844,0.761184924188818,-5.66135075780881,0.213482009098616,"ERLEC1","endoplasmic reticulum lectin 1",TRUE
+"224630_at",0.870808709484996,0.510452944157044,0.66892596725618,-5.72406016796508,0.176030286272505,"ERLEC1","endoplasmic reticulum lectin 1",TRUE
+"244452_at",0.970540753946729,0.859514029224113,0.179064974620473,-5.92407821576028,0.130340475942136,"ERLEC1","endoplasmic reticulum lectin 1",TRUE
+"202444_s_at",0.746259710622309,0.2379322695351,1.21292497975524,-5.24745214462536,0.510111160645408,"ERLIN1","ER lipid raft associated 1",TRUE
+"202441_at",0.919540842310091,0.658270506901418,0.448327292606531,-5.84225643076112,0.183126610982809,"ERLIN1","ER lipid raft associated 1",TRUE
+"221542_s_at",0.635821858586292,0.106737780522192,-1.68135448262276,-4.64926789314445,-1.14739835694235,"ERLIN2","ER lipid raft associated 2",TRUE
+"221543_s_at",0.663309898243682,0.131260523895685,-1.56711108673951,-4.80947695460541,-1.0766558963739,"ERLIN2","ER lipid raft associated 2",TRUE
+"238615_at",0.692948460442636,0.162302660894895,1.44554141754438,-4.97015056113355,1.21236604669625,"ERLIN2","ER lipid raft associated 2",TRUE
+"219905_at",0.71454754703986,0.189681742394941,-1.35306172073391,-5.08527274984248,-0.529524466310106,"ERMAP","erythroblast membrane associated protein (Scianna blood group)",TRUE
+"227656_at",0.960138290470901,0.819506197755803,0.230906642073753,-5.9137476235908,0.0713970626725065,"ERMARD","ER membrane associated RNA degradation",TRUE
+"231911_at",0.772430642757484,0.282850849726199,1.1006794570481,-5.36623099871246,0.830371157612115,"ERMN","ermin",TRUE
+"222603_at",0.858826390511142,0.474970149055164,-0.726779627584004,-5.68563613269261,-0.608303295246989,"ERMP1","endoplasmic reticulum metallopeptidase 1",TRUE
+"218342_s_at",0.92365974445982,0.67210574582353,-0.428944014938507,-5.85046246575252,-0.277121202033513,"ERMP1","endoplasmic reticulum metallopeptidase 1",TRUE
+"235745_at",0.947926063538122,0.762925697817474,-0.305382028807017,-5.89436265766006,-0.12842163748055,"ERN1","endoplasmic reticulum to nucleus signaling 1",TRUE
+"207061_at",0.990810941805126,0.954900984948191,0.0571969651910575,-5.93809018282661,0.0173680899641981,"ERN1","endoplasmic reticulum to nucleus signaling 1",TRUE
+"227755_at",0.994634231353802,0.975117621761934,-0.0315446467016314,-5.93919883302596,-0.0141938646321904,"ERN1","endoplasmic reticulum to nucleus signaling 1",TRUE
+"223910_at",0.697412165374288,0.167870190313122,1.4257769973421,-4.99528002325579,0.344159220070267,"ERN2","endoplasmic reticulum to nucleus signaling 2",TRUE
+"214372_x_at",0.755158214384019,0.24913660486619,-1.18354455786966,-5.27951744953936,-0.501825215723814,"ERN2","endoplasmic reticulum to nucleus signaling 2",TRUE
+"218498_s_at",0.30066408902823,0.00570808092201743,3.05981286854793,-2.18654318151014,1.12822020546293,"ERO1A","endoplasmic reticulum oxidoreductase 1 alpha",TRUE
+"225750_at",0.308621629697291,0.00636717326563411,3.01291500258046,-2.28180422936288,1.23567412962507,"ERO1A","endoplasmic reticulum oxidoreductase 1 alpha",TRUE
+"222646_s_at",0.622917527985155,0.0935346629270881,1.75239865486061,-4.54534496229283,0.816813825708264,"ERO1A","endoplasmic reticulum oxidoreductase 1 alpha",TRUE
+"231944_at",0.610486790071853,0.0831804310874553,-1.814403114981,-4.4520616574575,-1.43942763921872,"ERO1B","endoplasmic reticulum oxidoreductase 1 beta",TRUE
+"220012_at",0.791353982620776,0.321880445461107,-1.01324584663426,-5.45163318330888,-1.02032083164658,"ERO1B","endoplasmic reticulum oxidoreductase 1 beta",TRUE
+"227450_at",0.597654932724127,0.0738834982700078,1.87605767175948,-4.3569959640392,1.6118966772214,"ERP27","endoplasmic reticulum protein 27",TRUE
+"201216_at",0.928295253101366,0.685341018186159,-0.41055644630977,-5.85791758102156,-0.12509338846651,"ERP29","endoplasmic reticulum protein 29",TRUE
+"208958_at",0.760413486033505,0.259131670265684,-1.15815739399154,-5.30667146705339,-0.767602629524436,"ERP44","endoplasmic reticulum protein 44",TRUE
+"208959_s_at",0.801587742916188,0.338935368646852,0.977374355159985,-5.48482292205151,0.307882383332172,"ERP44","endoplasmic reticulum protein 44",TRUE
+"208957_at",0.975398143273847,0.882460900462793,0.149564999551409,-5.92879389971796,0.0407218164184027,"ERP44","endoplasmic reticulum protein 44",TRUE
+"224657_at",0.792436690618566,0.323914062450853,1.00890038119135,-5.45571154642095,0.761110097363412,"ERRFI1","ERBB receptor feedback inhibitor 1",TRUE
+"1562777_at",0.812302873476553,0.360554359456555,0.933638222104909,-5.52381077437516,0.486093103835697,"ERV3-1","endogenous retrovirus group 3 member 1",TRUE
+"222139_at",0.820536502908875,0.379696412179944,0.89636016737946,-5.55574534791501,0.890783709007719,"ERV3-2","endogenous retrovirus group 3 member 2",TRUE
+"215594_at",0.917102138198416,0.649628691546163,-0.460523191374234,-5.83691094783749,-0.317217262031479,"ERV9-1","endogenous retrovirus group 9 member 1",TRUE
+"1557914_s_at",0.74785911004212,0.239752619676603,-1.20808181308009,-5.25278490204825,-0.752086488299065,"ERVFH21-1","endogenous retrovirus group FH21 member 1",TRUE
+"1555880_at",0.922908550456534,0.669861964633143,0.43207604878494,-5.84916061716673,0.122187266107276,"ERVFRD-1","endogenous retrovirus group FRD member 1",TRUE
+"1570266_x_at",0.992984076039555,0.966518462434848,0.0424522016135294,-5.93880573884904,0.0185374134606038,"ERVH-1","endogenous retrovirus group H member 1",TRUE
+"1557919_a_at",0.980000734884886,0.904742545302936,0.121049953831118,-5.93254901940562,0.0658706638070994,"ERVH-3","endogenous retrovirus group H member 3",TRUE
+"208360_s_at",0.74126098489332,0.231904101774539,1.22916591176726,-5.22943470418141,0.444552287928548,"ERVH-4","endogenous retrovirus group H member 4",TRUE
+"1555742_at",0.540483367247649,0.0448541220625344,2.1263273012109,-3.94902240674561,1.45701179552179,"ERVH-6","endogenous retrovirus group H member 6",TRUE
+"1555743_s_at",0.719003127987809,0.195021790362308,1.33627500047366,-5.10549012198309,1.20726125261354,"ERVH-6","endogenous retrovirus group H member 6",TRUE
+"1555753_x_at",0.738061563377262,0.224876071501306,1.24851034375271,-5.20770472567424,0.787655812329067,"ERVH-6","endogenous retrovirus group H member 6",TRUE
+"211614_at",0.943464796017993,0.746581432086136,0.327208586221214,-5.88766996236127,0.153519824401464,"ERVH-6","endogenous retrovirus group H member 6",TRUE
+"232191_at",0.820536502908875,0.379972057938334,0.895832546817196,-5.55618871436919,0.465674694828135,"ERVH48-1","endogenous retrovirus group 48 member 1",TRUE
+"1566505_at",0.603702127972549,0.0782835029650398,1.84608495483292,-4.40349397407329,1.31443987681212,"ERVK13-1","endogenous retrovirus group K13 member 1",TRUE
+"1563629_a_at",0.812025911201313,0.356177510789756,-0.942346511856855,-5.51617830443416,-0.378425157437103,"ERVK13-1","endogenous retrovirus group K13 member 1",TRUE
+"1561942_x_at",0.981488198026236,0.91199865409282,0.111787227351084,-5.93359878505139,0.0790178116534515,"ERVK13-1","endogenous retrovirus group K13 member 1",TRUE
+"242140_at",0.830592576740524,0.403148106511545,-0.8523340815463,-5.59190723641568,-0.503161887511643,"ERVK3-1///ZNF8","endogenous retrovirus group K3 member 1///zinc finger protein 8",TRUE
+"242139_s_at",0.912252515563073,0.632333550464804,-0.485148197617713,-5.82568970820475,-0.305362466605082,"ERVK3-1///ZNF8","endogenous retrovirus group K3 member 1///zinc finger protein 8",TRUE
+"221200_at",0.62932992642067,0.100227969850824,-1.71538528294248,-4.59988895610471,-1.27800205208378,"ERVK3-2","endogenous retrovirus group K3 member 2",TRUE
+"219987_at",0.819018525257656,0.373731854512175,0.907839394192223,-5.54603947732714,0.695527891379677,"ERVMER34-1","endogenous retrovirus group MER34 member 1",TRUE
+"1561331_at",0.743323328391634,0.233558493469494,1.22467717374501,-5.23443515669514,1.04277159881228,"ERVMER61-1","endogenous retrovirus group MER61 member 1",TRUE
+"1553255_at",0.735677568529031,0.220774504829921,1.26001383670566,-5.19464444308693,0.638162849357705,"ERVV-1","endogenous retrovirus group V member 1",TRUE
+"1555299_s_at",0.819193107051406,0.375694987083806,0.904047947543325,-5.54925782813445,0.701310852987287,"ERVW-1","endogenous retrovirus group W member 1",TRUE
+"1553352_x_at",0.95643295620889,0.802691050632989,-0.252881674547647,-5.90858412172238,-0.1293190028199,"ERVW-1","endogenous retrovirus group W member 1",TRUE
+"225369_at",0.813442508625161,0.363929409195595,-0.926971452237788,-5.529609916443,-0.986413352707133,"ESAM","endothelial cell adhesion molecule",TRUE
+"235216_at",0.750042714158968,0.24299051844349,-1.19953517406757,-5.26215033027492,-0.429178508801377,"ESCO1","establishment of sister chromatid cohesion N-acetyltransferase 1",TRUE
+"235645_at",0.854184492233394,0.46477813911511,-0.743858392508203,-5.67371395025462,-0.28656165661857,"ESCO1","establishment of sister chromatid cohesion N-acetyltransferase 1",TRUE
+"226866_at",0.97649060127871,0.888367347138377,0.141994812928581,-5.92986782619557,0.0402785062422328,"ESCO1","establishment of sister chromatid cohesion N-acetyltransferase 1",TRUE
+"1564473_at",0.861659105448003,0.483139387603301,0.713245197828208,-5.69489717884126,0.398853219113787,"ESCO2","establishment of sister chromatid cohesion N-acetyltransferase 2",TRUE
+"235178_x_at",0.910602956673514,0.627753939514185,-0.491719336373495,-5.8225987536655,-0.162519331599879,"ESCO2","establishment of sister chromatid cohesion N-acetyltransferase 2",TRUE
+"241252_at",0.983136574792668,0.917922415995432,-0.104232755968042,-5.9343931842976,-0.0688774642842427,"ESCO2","establishment of sister chromatid cohesion N-acetyltransferase 2",TRUE
+"235588_at",0.993819570187391,0.970753140657116,-0.0370801726983324,-5.93901382074369,-0.0144072289432193,"ESCO2","establishment of sister chromatid cohesion N-acetyltransferase 2",TRUE
+"240808_at",0.55074985379986,0.0491160824217062,2.08181719929129,-4.024039447816,1.11575589618864,"ESD","esterase D",TRUE
+"228162_at",0.745519608574077,0.237175456269547,1.21494676286872,-5.24522051151768,0.659867857362464,"ESD","esterase D",TRUE
+"209009_at",0.768852835478002,0.273003845572474,1.12409609109047,-5.34228971560646,0.67483284385002,"ESD","esterase D",TRUE
+"215096_s_at",0.797508506396963,0.330918280239811,0.994077241862329,-5.46950393663929,0.696136327179675,"ESD","esterase D",TRUE
+"215095_at",0.865854896594418,0.496028074627976,0.692158677481927,-5.70899524564086,0.340039250732184,"ESD","esterase D",TRUE
+"218859_s_at",0.938984663220785,0.727259042124912,0.353223991163813,-5.87909602143189,0.132669981024213,"ESF1","ESF1 nucleolar pre-rRNA processing protein homolog",TRUE
+"222765_x_at",0.95952608973576,0.817135729606112,-0.233997227452037,-5.91304961729955,-0.0941132319701978,"ESF1","ESF1 nucleolar pre-rRNA processing protein homolog",TRUE
+"208394_x_at",0.857287594027564,0.472216188747461,0.731372946529497,-5.68245551454112,0.601944167723371,"ESM1","endothelial cell specific molecule 1",TRUE
+"38158_at",0.69887421412603,0.170205820901139,-1.41764215290858,-5.00554073298225,-0.429938349719095,"ESPL1","extra spindle pole bodies like 1, separase",TRUE
+"204817_at",0.734730148360473,0.21958653933835,-1.26337621378458,-5.1908076445884,-0.451495315376228,"ESPL1","extra spindle pole bodies like 1, separase",TRUE
+"219422_at",0.627092759817312,0.098010295915862,1.72740852514321,-4.58226609582174,0.832915156856787,"ESPN","espin",TRUE
+"233979_s_at",0.707694888507328,0.179186552033643,1.38717087062061,-5.04354485100304,1.40544073222312,"ESPN","espin",TRUE
+"223549_s_at",0.863918945062466,0.490258706155935,0.701558196644633,-5.70276072341358,0.733115704632302,"ESPN","espin",TRUE
+"1557000_at",0.808257777979515,0.350578652312895,0.953591947803138,-5.50622599995751,0.370749483479742,"ESPNL","espin-like",TRUE
+"1557002_x_at",0.953902670233338,0.787061841590708,0.273421378147031,-5.90333646165727,0.120901070864784,"ESPNL","espin-like",TRUE
+"234281_at",0.950214160603623,0.774161678721324,0.290465197873156,-5.89867329151992,0.203561996520919,"ESPNP///ESPN","espin pseudogene///espin",TRUE
+"211235_s_at",0.647754107214051,0.119230940056686,-1.62068688884025,-4.7354277588336,-1.59384268716071,"ESR1","estrogen receptor 1",TRUE
+"215551_at",0.786455312223125,0.312214388368785,1.03416716397229,-5.43177616455521,0.485461730372966,"ESR1","estrogen receptor 1",TRUE
+"211234_x_at",0.821137675198948,0.38214823741459,-0.891675863399281,-5.5596731804636,-0.616276838725584,"ESR1","estrogen receptor 1",TRUE
+"217190_x_at",0.831487912516861,0.406067696199876,-0.846969899747854,-5.59619741070982,-0.73183528583204,"ESR1","estrogen receptor 1",TRUE
+"205225_at",0.871451481476429,0.512586351666087,-0.665521375218572,-5.72622647341462,-0.980381788587964,"ESR1","estrogen receptor 1",TRUE
+"211627_x_at",0.871744769522775,0.513967450476905,-0.663321562563972,-5.72762055831673,-0.622172465170114,"ESR1","estrogen receptor 1",TRUE
+"215552_s_at",0.873595434130859,0.518988431635848,-0.655351676603557,-5.73263424523792,-0.775050676190737,"ESR1","estrogen receptor 1",TRUE
+"217163_at",0.900867933475689,0.596880759644553,0.536615475352603,-5.80039556151061,0.393815183277019,"ESR1","estrogen receptor 1",TRUE
+"211233_x_at",0.936456142259101,0.716490982957657,0.367829332861891,-5.87399860719909,0.303068258251978,"ESR1","estrogen receptor 1",TRUE
+"211119_at",0.398743678334163,0.0140171074487108,2.66743823758704,-2.96513635218428,1.43338846905698,"ESR2","estrogen receptor 2",TRUE
+"211120_x_at",0.863230457544525,0.487308532722434,0.706389200693423,-5.69952521340827,0.404386163583861,"ESR2","estrogen receptor 2",TRUE
+"210780_at",0.863569008901048,0.488754436811403,0.704019387442694,-5.70111501350974,0.489882910739013,"ESR2","estrogen receptor 2",TRUE
+"211118_x_at",0.965466249068251,0.838700417298615,0.205963166248106,-5.91904295632917,0.117323912457568,"ESR2","estrogen receptor 2",TRUE
+"1569554_at",0.968265867104331,0.850723768225625,0.190407292151459,-5.92204044947898,0.146439774285974,"ESR2","estrogen receptor 2",TRUE
+"211117_x_at",0.986342822130003,0.933366116648812,0.0845657116218539,-5.936200917338,0.0593952595676592,"ESR2","estrogen receptor 2",TRUE
+"225846_at",0.851733415458562,0.456774385056504,0.757426882463777,-5.66405515301001,1.04078269335528,"ESRP1","epithelial splicing regulatory protein 1",TRUE
+"219121_s_at",0.869197499366046,0.506145587285161,0.675824194367765,-5.71963845720145,1.13172440535347,"ESRP1","epithelial splicing regulatory protein 1",TRUE
+"1487_at",0.839781238235762,0.428516619544752,-0.806518180723793,-5.62773374404497,-0.247918649397381,"ESRRA","estrogen related receptor alpha",TRUE
+"203193_at",0.929125618312698,0.68817287725109,0.406641030169036,-5.85946357459114,0.132288155192132,"ESRRA","estrogen related receptor alpha",TRUE
+"1556156_at",0.358427723880268,0.0101516329747792,-2.81028624861118,-2.68684962582632,-1.8784939960653,"ESRRB","estrogen related receptor beta",TRUE
+"223858_at",0.804537788156734,0.343311798999642,0.96837069912282,-5.49298244019075,0.537264655393527,"ESRRB","estrogen related receptor beta",TRUE
+"207726_at",0.929088231432081,0.687945367225256,-0.40695535296874,-5.85934000311677,-0.128428642330382,"ESRRB","estrogen related receptor beta",TRUE
+"209966_x_at",0.700061364939874,0.171466310132296,-1.41328904470528,-5.01101162338275,-1.12784492405334,"ESRRG","estrogen related receptor gamma",TRUE
+"207981_s_at",0.83030603167465,0.402370985330575,-0.85376607760352,-5.59075768250383,-0.823191946319282,"ESRRG","estrogen related receptor gamma",TRUE
+"1552445_a_at",0.691814633378193,0.161379128195802,1.44887252629025,-4.96588743488589,1.36955951763835,"ESX1","ESX homeobox 1",TRUE
+"208858_s_at",0.796526145641047,0.329316173576873,-0.9974484742372,-5.46638340544491,-0.35056114357862,"ESYT1","extended synaptotagmin 1",TRUE
+"224699_s_at",0.852006864319744,0.457267975890799,0.756586016886157,-5.6646585307054,0.337773323968852,"ESYT2","extended synaptotagmin 2",TRUE
+"1555830_s_at",0.89316156038085,0.567420889761977,0.580521716087595,-5.77686023910001,0.284979089483041,"ESYT2","extended synaptotagmin 2",TRUE
+"1555829_at",0.976422537443518,0.887981781217543,0.142488721803545,-5.92979945614863,0.114975076106662,"ESYT2","extended synaptotagmin 2",TRUE
+"1558511_s_at",0.990810941805126,0.955616125422125,0.0562889762706473,-5.93814036396069,0.0272638547008999,"ESYT2","extended synaptotagmin 2",TRUE
+"224698_at",0.998038817582822,0.990851419503914,-0.0115963789010053,-5.93961798265806,-0.00775138991724944,"ESYT2","extended synaptotagmin 2",TRUE
+"239770_at",0.711902920992134,0.185548646800019,1.36631161710134,-5.06916606104035,0.920622471521193,"ESYT3","extended synaptotagmin 3",TRUE
+"1554912_at",0.816800680706682,0.368615442752117,0.917783223207497,-5.5375396739066,0.82852910939677,"ESYT3","extended synaptotagmin 3",TRUE
+"1557793_at",0.980025041090473,0.906189483410584,0.119202037192285,-5.93276510839525,0.0751314850553424,"ESYT3","extended synaptotagmin 3",TRUE
+"219216_at",0.732595971142787,0.216931481898522,1.27094176823356,-5.18214263734997,0.413707565090577,"ETAA1","Ewing tumor associated antigen 1",TRUE
+"201574_at",0.564004192185035,0.0559365923395307,-2.01731715803214,-4.13091220510725,-0.588770718030458,"ETF1","eukaryotic translation termination factor 1",TRUE
+"201573_s_at",0.754491163266461,0.24771068868634,-1.18722790100132,-5.27553503856798,-0.31445289679028,"ETF1","eukaryotic translation termination factor 1",TRUE
+"201931_at",0.640987277293074,0.111464842439347,-1.65772900414744,-4.68310808716865,-0.606884969030116,"ETFA","electron transfer flavoprotein alpha subunit",TRUE
+"202942_at",0.791211889207316,0.321638756558145,-1.01376356282824,-5.45114623162708,-0.499560080012047,"ETFB","electron transfer flavoprotein beta subunit",TRUE
+"1554582_a_at",0.555307820043702,0.0514712284114316,-2.05868772911093,-4.06261681819585,-1.2125265744064,"ETFBKMT","electron transfer flavoprotein beta subunit lysine methyltransferase",TRUE
+"1569792_a_at",0.757950630724418,0.254045007534714,-1.17098453759231,-5.29301599718864,-0.487693901542483,"ETFBKMT","electron transfer flavoprotein beta subunit lysine methyltransferase",TRUE
+"1554583_a_at",0.784552021081681,0.308079444518306,1.04325607323712,-5.42303562781534,0.539650210472642,"ETFBKMT","electron transfer flavoprotein beta subunit lysine methyltransferase",TRUE
+"1563474_at",0.832741974897873,0.409532289771505,0.840636213075049,-5.60123043706022,0.50966135105143,"ETFBKMT","electron transfer flavoprotein beta subunit lysine methyltransferase",TRUE
+"1563475_s_at",0.997658807362705,0.988571764179045,0.0144861700374448,-5.93958127149552,0.00835232294394483,"ETFBKMT","electron transfer flavoprotein beta subunit lysine methyltransferase",TRUE
+"205530_at",0.545085128927207,0.0469266703586715,-2.10422873671087,-3.98639416131183,-0.817593537137164,"ETFDH","electron transfer flavoprotein dehydrogenase",TRUE
+"33494_at",0.562894650172193,0.0554871355730338,-2.02134528826184,-4.12430277421046,-0.862488021477336,"ETFDH","electron transfer flavoprotein dehydrogenase",TRUE
+"204034_at",0.912722788750542,0.6341594355518,0.482534337566909,-5.82690792410371,0.180989375242685,"ETHE1","ETHE1, persulfide dioxygenase",TRUE
+"224454_at",0.637485146909712,0.10901666435493,1.66985675842937,-4.66578220702409,1.21707192321749,"ETNK1","ethanolamine kinase 1",TRUE
+"224453_s_at",0.87548954903345,0.522834124261671,0.649276104938037,-5.7364172002634,0.270226182971324,"ETNK1","ethanolamine kinase 1",TRUE
+"226432_at",0.890589821844314,0.55934090338019,0.59276434127415,-5.7699782957295,0.294027569676105,"ETNK1","ethanolamine kinase 1",TRUE
+"222262_s_at",0.900867933475689,0.596796362398174,0.536739706844186,-5.80033150431978,0.254593023943784,"ETNK1","ethanolamine kinase 1",TRUE
+"219017_at",0.946913677125713,0.758933776777794,0.310698576920863,-5.89277458593488,0.166961713197368,"ETNK1","ethanolamine kinase 1",TRUE
+"225290_at",0.981140604770329,0.91092198224694,0.11316099115105,-5.93344836174283,0.0655557182878628,"ETNK1","ethanolamine kinase 1",TRUE
+"219268_at",0.832605695407954,0.409091866563084,-0.84143946133887,-5.60059409338238,-0.697648237065295,"ETNK2","ethanolamine kinase 2",TRUE
+"221008_s_at",0.683838837468118,0.152821671247352,1.48049541503672,-4.92502047994387,1.16999911303135,"ETNPPL","ethanolamine-phosphate phospho-lyase",TRUE
+"1555355_a_at",0.409937516868549,0.0158326001050436,2.61284405874993,-3.06970591066458,5.2167268767426,"ETS1","ETS proto-oncogene 1, transcription factor",TRUE
+"224833_at",0.411110107932987,0.016073996720363,2.60603334171574,-3.08267769826272,4.97223011708583,"ETS1","ETS proto-oncogene 1, transcription factor",TRUE
+"214447_at",0.65897069706746,0.127081610057234,1.58524110354194,-4.78463604517899,1.01791235133685,"ETS1","ETS proto-oncogene 1, transcription factor",TRUE
+"201329_s_at",0.358427723880268,0.0100835234983584,2.81324130270773,-2.68102545261944,1.86973754822188,"ETS2","ETS proto-oncogene 2, transcription factor",TRUE
+"201328_at",0.541879135605867,0.0453447576851588,2.12101411847323,-3.95803041876975,2.21143969925075,"ETS2","ETS proto-oncogene 2, transcription factor",TRUE
+"241193_at",0.871708868449496,0.513284974090685,0.664408198416538,-5.72693247852206,0.486318168689674,"ETS2","ETS proto-oncogene 2, transcription factor",TRUE
+"221911_at",0.740610299769501,0.23069655263602,1.23245762696756,-5.22575770046904,2.32736458783206,"ETV1","ETS variant 1",TRUE
+"217053_x_at",0.758081075834994,0.254777325898589,1.16912615250042,-5.29500255028292,1.07912638757004,"ETV1","ETS variant 1",TRUE
+"217061_s_at",0.841088238127348,0.430917281466575,0.802271662008801,-5.63096042158068,0.546042981673141,"ETV1","ETS variant 1",TRUE
+"206501_x_at",0.89102917330053,0.560239281210944,0.591398646533981,-5.77075287569443,0.354758426352091,"ETV1","ETS variant 1",TRUE
+"221910_at",0.910263605770897,0.627011794719222,0.492786278790026,-5.82209304768456,0.3315473867357,"ETV1","ETS variant 1",TRUE
+"215510_at",0.970540753946729,0.859659726959098,-0.178877183374273,-5.92411090489477,-0.0893962191403288,"ETV2","ETS variant 2",TRUE
+"227200_at",0.873230718105642,0.51770644303944,-0.657382524560166,-5.73136219949541,-0.282590177654622,"ETV3","ETS variant 3",TRUE
+"1552423_at",0.891466803032047,0.561179779181655,0.589970136536265,-5.7715612341741,0.208549892966668,"ETV3","ETS variant 3",TRUE
+"214480_at",0.955892698633978,0.799460097280922,-0.257118349795426,-5.90753501114305,-0.149603445422252,"ETV3","ETS variant 3",TRUE
+"211603_s_at",0.594005743610726,0.0710406751322117,1.89626270765352,-4.32535347046803,2.03671976746892,"ETV4","ETS variant 4",TRUE
+"1554576_a_at",0.606900628956089,0.0803150175598828,1.83273850557035,-4.42402728688984,2.0369752914893,"ETV4","ETS variant 4",TRUE
+"231083_at",0.767727587789514,0.270128747418381,-1.13104924179204,-5.33509490870516,-0.492374937971515,"ETV5","ETS variant 5",TRUE
+"203348_s_at",0.790817398514927,0.320684277856205,1.01581078712677,-5.44921845570135,1.07734769109874,"ETV5","ETS variant 5",TRUE
+"203349_s_at",0.84571977676742,0.443459421129292,0.78032011485366,-5.64738449986739,0.714086743699504,"ETV5","ETS variant 5",TRUE
+"216375_s_at",0.953553103224247,0.78578464920867,0.275105048418572,-5.90288826584846,0.181765014007946,"ETV5","ETS variant 5",TRUE
+"230102_at",0.95436083758186,0.789920215459214,0.269656216603321,-5.90432886829766,0.44598788868659,"ETV5","ETS variant 5",TRUE
+"205585_at",0.495672562291005,0.0302328418049475,2.31538839433456,-3.61955225112543,1.01243233334975,"ETV6","ETS variant 6",TRUE
+"239364_at",0.552218043161514,0.0494272035890997,2.0787055073902,-4.02924568070109,1.3677278731658,"ETV6","ETS variant 6",TRUE
+"225764_at",0.69769051685394,0.168160322470987,1.42476156854465,-4.9965634424478,0.641872149572725,"ETV6","ETS variant 6",TRUE
+"235056_at",0.725991386434717,0.205077515992394,1.30561733276043,-5.1418645520308,0.696414265675749,"ETV6","ETS variant 6",TRUE
+"239740_at",0.998347572104896,0.992554224838794,0.0094378955487062,-5.9396400962431,0.00406778169613453,"ETV6","ETS variant 6",TRUE
+"221680_s_at",0.606900628956089,0.0805211182126871,1.83140091895298,-4.42607926653158,0.741523519071203,"ETV7","ETS variant 7",TRUE
+"224225_s_at",0.713330901550199,0.187868493360176,1.35884631724116,-5.07825705897474,1.35412794180857,"ETV7","ETS variant 7",TRUE
+"227828_s_at",0.657318133823516,0.126170372561099,1.58926010908099,-4.77909914594272,1.75286724590251,"EVA1A","eva-1 homolog A, regulator of programmed cell death",TRUE
+"229998_x_at",0.493519901382617,0.0298481952822468,2.32141647035091,-3.6087738107035,0.551562082856544,"EVA1B","eva-1 homolog B",TRUE
+"221710_x_at",0.941311073534434,0.737369717031457,0.339581278001033,-5.8836731255798,0.190082986199084,"EVA1B","eva-1 homolog B",TRUE
+"220134_x_at",0.989654520357877,0.950245327730351,-0.0631093308609871,-5.93774379790476,-0.0277414406880565,"EVA1B","eva-1 homolog B",TRUE
+"227188_at",0.889452275006221,0.557410331019741,0.595703013505719,-5.76830571590666,0.588408778789042,"EVA1C","eva-1 homolog C",TRUE
+"234421_s_at",0.767727587789514,0.26997445300095,1.13142391745882,-5.33470609841985,0.775827221365464,"EVC","EvC ciliary complex subunit 1",TRUE
+"210887_s_at",0.90344422113846,0.603969501069568,0.526211146029465,-5.80570911415014,0.4110897715783,"EVC","EvC ciliary complex subunit 1",TRUE
+"219432_at",0.953553103224247,0.785694076146956,0.275224477958221,-5.90285636975881,0.344888125692169,"EVC","EvC ciliary complex subunit 1",TRUE
+"229974_at",0.315093142651413,0.0067603752385114,2.98711230018221,-2.33398763774044,2.4243854410095,"EVC2","EvC ciliary complex subunit 2",TRUE
+"1555256_at",0.67368843181164,0.140152588491869,1.53006941143937,-4.85952915930214,1.25246322161551,"EVC2","EvC ciliary complex subunit 2",TRUE
+"204774_at",0.985032035638346,0.926194050894143,-0.0936943692903498,-5.93540863572635,-0.0862522793401688,"EVI2A","ecotropic viral integration site 2A",TRUE
+"211742_s_at",0.774230543658252,0.286086482179075,1.09311424877069,-5.37387000560966,1.22205784562174,"EVI2B","ecotropic viral integration site 2B",TRUE
+"208298_at",0.183534093706442,0.00175652712600001,3.55561325315236,-1.15298351356255,2.0342137887305,"EVI5","ecotropic viral integration site 5",TRUE
+"208297_s_at",0.793816937298172,0.325649678663561,1.00520668874327,-5.45916571181002,0.388069110550709,"EVI5","ecotropic viral integration site 5",TRUE
+"209717_at",0.940227139261806,0.732993437139341,0.345478139401018,-5.88171660518287,0.144604322190602,"EVI5","ecotropic viral integration site 5",TRUE
+"242534_at",0.761261833217751,0.260299228351506,-1.15523951572317,-5.3097593488579,-0.79939158295959,"EVI5L","ecotropic viral integration site 5 like",TRUE
+"244500_s_at",0.836902216536942,0.41897919471512,0.823537020463922,-5.61464182077188,0.555757235495022,"EVI5L","ecotropic viral integration site 5 like",TRUE
+"244501_at",0.932415412515157,0.701910774974203,0.387736734878077,-5.8667226228916,0.251864941098229,"EVI5L","ecotropic viral integration site 5 like",TRUE
+"226411_at",0.966925852992772,0.845776240493324,-0.196802386305229,-5.9208365389865,-0.0829382430353469,"EVI5L","ecotropic viral integration site 5 like",TRUE
+"217838_s_at",0.713633547141264,0.188592832240527,-1.35653028820523,-5.08106899352205,-0.950687837267029,"EVL","Enah/Vasp-like",TRUE
+"227232_at",0.722080068577879,0.198252202716994,-1.32629429467656,-5.11741004864179,-0.729533733000562,"EVL","Enah/Vasp-like",TRUE
+"204503_at",0.897300940949134,0.583429304629092,0.556525781399564,-5.7899453911018,0.265162409341361,"EVPL","envoplakin",TRUE
+"236933_at",0.831957210365167,0.408226615107611,0.843019119065384,-5.59934101287579,0.289944059305348,"EVPLL","envoplakin like",TRUE
+"207914_x_at",0.976364796498418,0.885821903667145,-0.145256193859402,-5.92941198174469,-0.0456095615321761,"EVX1","even-skipped homeobox 1",TRUE
+"231706_s_at",0.989219818614154,0.947425620516327,0.0666912732083204,-5.93751738961067,0.0355627751163818,"EVX1","even-skipped homeobox 1",TRUE
+"240912_x_at",0.94333312187812,0.745523980928165,0.328626218133979,-5.88721945963034,0.220720769301757,"EWSAT1","Ewing sarcoma associated transcript 1",TRUE
+"210011_s_at",0.953902670233338,0.787114464960971,0.273352024267142,-5.90335486519708,0.0902302103262222,"EWSR1","EWS RNA binding protein 1",TRUE
+"209214_s_at",0.982243328340126,0.914553611087563,0.108528143795233,-5.93394830466195,0.0276919450144089,"EWSR1","EWS RNA binding protein 1",TRUE
+"210012_s_at",0.984473578298083,0.92423780794852,0.0961856726690623,-5.9351783311769,0.0700349911277476,"EWSR1","EWS RNA binding protein 1",TRUE
+"229966_at",0.998870448604467,0.99593531700834,-0.00515213458011975,-5.93967055191462,-0.00174082498583239,"EWSR1","EWS RNA binding protein 1",TRUE
+"1553907_a_at",0.983567332578112,0.919944736066099,0.101655170819306,-5.93465153362767,0.0735113247665709,"EXD1","exonuclease 3'-5' domain containing 1",TRUE
+"218363_at",0.840872144163754,0.430275316381538,-0.803405789297442,-5.63010023164024,-0.312369622099389,"EXD2","exonuclease 3'-5' domain containing 2",TRUE
+"1555808_a_at",0.946391057046703,0.757585926909539,-0.312495737698712,-5.89223162644992,-0.169174311902021,"EXD2","exonuclease 3'-5' domain containing 2",TRUE
+"229131_at",0.955203530479627,0.795176176636134,-0.26274319588869,-5.90611539423967,-0.0938658787830757,"EXD2","exonuclease 3'-5' domain containing 2",TRUE
+"1555914_a_at",0.858788512648905,0.474654413602876,-0.727305445938016,-5.68527299757553,-0.600097423417733,"EXD3","exonuclease 3'-5' domain containing 3",TRUE
+"220838_at",0.866230449643216,0.497098245779708,-0.690422024494599,-5.71013834900072,-0.16871815016186,"EXD3","exonuclease 3'-5' domain containing 3",TRUE
+"241363_at",0.998870448604467,0.996365754214341,0.00460653538246148,-5.93967314519282,0.0050794922744295,"EXD3","exonuclease 3'-5' domain containing 3",TRUE
+"204603_at",0.936992192746977,0.718870901969149,-0.36459439959032,-5.87514521158849,-0.13562656074726,"EXO1","exonuclease 1",TRUE
+"219567_s_at",0.841618504666446,0.433424888517755,0.797851601667146,-5.63430196038144,0.375410590597822,"EXO5","exonuclease 5",TRUE
+"222902_s_at",0.917598799563752,0.650534333217927,0.459241790819823,-5.83747919816877,0.173140065850422,"EXO5","exonuclease 5",TRUE
+"222127_s_at",0.891653456393983,0.56158045775308,-0.589361927392255,-5.77190483094885,-0.163600562959358,"EXOC1","exocyst complex component 1",TRUE
+"219349_s_at",0.622434989367596,0.0927862125572636,1.75667721718913,-4.53898439483198,0.765741654923364,"EXOC2","exocyst complex component 2",TRUE
+"226270_at",0.661974206478491,0.129681787100134,1.57390328572584,-4.80019682334743,0.583510714064458,"EXOC2","exocyst complex component 2",TRUE
+"212630_at",0.724275694298914,0.201513564623428,1.31634608501981,-5.12921622857527,0.621202249595799,"EXOC3","exocyst complex component 3",TRUE
+"228847_at",0.843725309945907,0.439092089057171,0.787920080058447,-5.64174677589138,0.532093325347944,"EXOC3","exocyst complex component 3",TRUE
+"235219_at",0.739189560382301,0.225967595385795,-1.24547602989763,-5.211132534942,-0.695558286872282,"EXOC3-AS1","EXOC3 antisense RNA 1",TRUE
+"1554937_x_at",0.955925931146022,0.800957233058234,-0.255154596740043,-5.90802344092428,-0.156351359355213,"EXOC3L1","exocyst complex component 3 like 1",TRUE
+"1559272_at",0.985498770484702,0.929338762033296,-0.0896908006627811,-5.93576609017085,-0.0471885449280283,"EXOC3L1","exocyst complex component 3 like 1",TRUE
+"1552889_a_at",0.957017346544368,0.805350267444693,-0.249398253119847,-5.90943372964227,-0.0732024683719956,"EXOC3L2","exocyst complex component 3 like 2",TRUE
+"230677_at",0.854400503339099,0.465919002845494,0.741935702125341,-5.67506924496341,0.647550382932764,"EXOC3L4","exocyst complex component 3 like 4",TRUE
+"231209_at",0.932411919177942,0.701731758976567,-0.387982135602576,-5.86663057232488,-0.226664089930176,"EXOC3L4","exocyst complex component 3 like 4",TRUE
+"235974_at",0.931582451098271,0.698280217781649,-0.392718382486832,-5.86484274883875,-0.189304702463603,"EXOC4","exocyst complex component 4",TRUE
+"224926_at",0.976371465776674,0.887000301966294,-0.143746158107074,-5.92962432426089,-0.0467560483993896,"EXOC4","exocyst complex component 4",TRUE
+"240528_s_at",0.983051865094694,0.917555359816746,-0.104700671208587,-5.93434559251382,-0.0359950034914824,"EXOC4","exocyst complex component 4",TRUE
+"225084_at",0.819018525257656,0.374214952487225,-0.906905156485979,-5.54683365522759,-0.237588360387546,"EXOC5","exocyst complex component 5",TRUE
+"218748_s_at",0.841967750949524,0.434338942542173,-0.796244369110787,-5.63551271529,-0.246616384204454,"EXOC5","exocyst complex component 5",TRUE
+"228418_at",0.886654797568109,0.54965012860161,-0.60756935145391,-5.76147059974287,-0.179589192412426,"EXOC5","exocyst complex component 5",TRUE
+"224253_at",0.931301147119142,0.695405589982371,0.396669967869329,-5.86333476378765,0.390518990940294,"EXOC5","exocyst complex component 5",TRUE
+"222726_s_at",0.960138290470901,0.819507310910069,-0.230905191300221,-5.91374794907891,-0.0774220460946715,"EXOC5","exocyst complex component 5",TRUE
+"232599_at",0.658590024406624,0.126838106845531,1.58631271944321,-4.78316077250087,1.57617641218799,"EXOC6","exocyst complex component 6",TRUE
+"233924_s_at",0.954723352940649,0.79395586926291,-0.264347054288307,-5.90570501584235,-0.12125526371657,"EXOC6","exocyst complex component 6",TRUE
+"226259_at",0.978276691813018,0.895433184698724,-0.132949765572248,-5.93107799344311,-0.097051570470887,"EXOC6","exocyst complex component 6",TRUE
+"225900_at",0.134242602708516,0.000848691992435588,3.85549767796819,-0.511885792249964,1.15166398117501,"EXOC6B","exocyst complex component 6B",TRUE
+"215417_at",0.922168942129244,0.667619625843124,0.43521046394535,-5.84784846670412,0.167715335784929,"EXOC6B","exocyst complex component 6B",TRUE
+"212034_s_at",0.735001929272204,0.220066716124766,-1.26201546243005,-5.19236144847689,-0.441908147414269,"EXOC7","exocyst complex component 7",TRUE
+"215413_at",0.79279559916191,0.324627062540848,1.0073813309768,-5.4571334798414,0.614999935186174,"EXOC7","exocyst complex component 7",TRUE
+"212026_s_at",0.809411730389276,0.35261116447248,0.94949565870075,-5.50986377740854,0.41022638499561,"EXOC7","exocyst complex component 7",TRUE
+"214802_at",0.955515814503015,0.796235400929847,0.261351620901414,-5.90646944570552,0.211742616392324,"EXOC7","exocyst complex component 7",TRUE
+"212035_s_at",0.999188340279058,0.99743393551149,0.00325257168811277,-5.93967832800115,0.0011434066667082,"EXOC7","exocyst complex component 7",TRUE
+"227577_at",0.827866702343255,0.397337377408331,-0.863084745194207,-5.58323310380016,-0.33043405377579,"EXOC8","exocyst complex component 8",TRUE
+"206902_s_at",0.64790483160958,0.11929506977254,-1.62038954492307,-4.73584405709035,-1.06237195765034,"EXOG","endo/exonuclease (5'-3'), endonuclease G-like",TRUE
+"205521_at",0.83986604340123,0.428681146286202,0.806226679234871,-5.6279557501138,0.374130056039466,"EXOG","endo/exonuclease (5'-3'), endonuclease G-like",TRUE
+"206903_at",0.970540753946729,0.859601364379053,-0.178952406687978,-5.92409781475274,-0.093603356539024,"EXOG","endo/exonuclease (5'-3'), endonuclease G-like",TRUE
+"218369_s_at",0.86565139019074,0.495587861713765,-0.69287366653832,-5.70852382729053,-0.440053145157842,"EXOSC1","exosome component 1",TRUE
+"222609_s_at",0.919095054289206,0.655534076834235,-0.452181568180544,-5.84058229591488,-0.168962507033324,"EXOSC1","exosome component 1",TRUE
+"1559044_at",0.936318756756998,0.715974385455442,-0.368532051460792,-5.87374821068632,-0.317683343328241,"EXOSC1","exosome component 1",TRUE
+"1559031_at",0.827206876786434,0.39596997492921,0.86562931589463,-5.58116521825174,0.572205328292624,"EXOSC10","exosome component 10",TRUE
+"207541_s_at",0.936992192746977,0.718211523733471,0.365490268933218,-5.87482867667466,0.132345942868261,"EXOSC10","exosome component 10",TRUE
+"214507_s_at",0.535243600695458,0.0427051686057211,-2.15023414758311,-3.90831461713759,-0.66588010186517,"EXOSC2","exosome component 2",TRUE
+"216117_at",0.861659105448003,0.482725311792074,-0.713927997875528,-5.69443393467682,-0.450196505633674,"EXOSC2","exosome component 2",TRUE
+"209527_at",0.96736559784358,0.847259744841222,0.194883963395596,-5.92120185256688,0.0539912244870919,"EXOSC2","exosome component 2",TRUE
+"233495_at",0.748136676097718,0.24013551184944,-1.20706663269279,-5.2539003599539,-0.534554484333232,"EXOSC3","exosome component 3",TRUE
+"227912_s_at",0.839766955721852,0.428446259348168,0.806642863173327,-5.62763876350868,0.254997122755418,"EXOSC3","exosome component 3",TRUE
+"223489_x_at",0.89102917330053,0.560233541930958,0.59140736766081,-5.77074793481975,0.221021068461839,"EXOSC3","exosome component 3",TRUE
+"227913_at",0.895457620469779,0.574322991517282,0.570134342077657,-5.78259025029476,0.251391628237047,"EXOSC3","exosome component 3",TRUE
+"223490_s_at",0.9116561917482,0.630665531854438,-0.487539062037123,-5.8245697884786,-0.221774914878173,"EXOSC3","exosome component 3",TRUE
+"227916_x_at",0.997056683282451,0.985110777779884,-0.0188737183153238,-5.93950998195297,-0.00792546831051943,"EXOSC3","exosome component 3",TRUE
+"218695_at",0.931582451098271,0.698310957863514,-0.392676160354168,-5.86485878113676,-0.150598356825276,"EXOSC4","exosome component 4",TRUE
+"91684_g_at",0.934048461921637,0.707866676566791,-0.379585894548018,-5.86974740219956,-0.138614953004042,"EXOSC4","exosome component 4",TRUE
+"58696_at",0.976371465776674,0.88667197856081,0.144166847250494,-5.92956538913216,0.0570492196868475,"EXOSC4","exosome component 4",TRUE
+"218481_at",0.80764044633141,0.349075980821711,-0.956630763668815,-5.50351806602708,-0.349910396536105,"EXOSC5","exosome component 5",TRUE
+"227696_at",0.224133347660554,0.00275068086475047,-3.36875880538502,-1.54737466554265,-1.32784989858379,"EXOSC6","exosome component 6",TRUE
+"1558044_s_at",0.64513208805899,0.116023088557182,-1.63573432103068,-4.71428367775485,-0.522228654463493,"EXOSC6","exosome component 6",TRUE
+"1553947_at",0.724970327905974,0.20301142734256,-1.31181914333822,-5.13456379606965,-0.491501638345799,"EXOSC6","exosome component 6",TRUE
+"212627_s_at",0.976660494182006,0.888880293127518,0.141337786580501,-5.92995840877027,0.0511541376530431,"EXOSC7","exosome component 7",TRUE
+"213648_at",0.98427503418599,0.923564412797869,0.0970433945240103,-5.93509764319908,0.0223502567271243,"EXOSC7","exosome component 7",TRUE
+"205200_at",0.821745015752602,0.38461746921173,-0.886978170482718,-5.56359309990026,-0.843863034356625,"EXOSC7///CLEC3B","exosome component 7///C-type lectin domain family 3 member B",TRUE
+"215136_s_at",0.853170381292938,0.459655527215584,0.752526326814932,-5.66756270830531,0.308646825310296,"EXOSC8","exosome component 8",TRUE
+"205061_s_at",0.966064677476069,0.841795408232354,-0.201954036126338,-5.91983790179098,-0.103073667531165,"EXOSC9","exosome component 9",TRUE
+"214734_at",0.592111379991983,0.0691827841476113,1.90985348641211,-4.30393614098028,1.47553268423138,"EXPH5","exophilin 5",TRUE
+"213929_at",0.702630084418366,0.174124850494225,1.40419100999816,-5.02240110902851,0.955195832996525,"EXPH5","exophilin 5",TRUE
+"215226_at",0.925511384407886,0.677337867694563,0.42165748143597,-5.85345514550183,0.219725543186728,"EXPH5","exophilin 5",TRUE
+"230183_at",0.566552750683806,0.0570231328214538,2.0076970143476,-4.14666159045434,1.44083486132926,"EXT1","exostosin glycosyltransferase 1",TRUE
+"201995_at",0.610033432202476,0.0824838465285157,1.81880950938931,-4.44534289774862,1.46452259755513,"EXT1","exostosin glycosyltransferase 1",TRUE
+"214985_at",0.66120440880682,0.128909814809973,1.57724954113068,-4.79561329189242,1.16511302302881,"EXT1","exostosin glycosyltransferase 1",TRUE
+"202012_s_at",0.933922051839063,0.707288215451509,0.380376380908703,-5.86945682701525,0.152547222903042,"EXT2","exostosin glycosyltransferase 2",TRUE
+"202013_s_at",0.990984475090957,0.957794043145274,-0.0535240454984176,-5.93828822720066,-0.0237987108642805,"EXT2","exostosin glycosyltransferase 2",TRUE
+"206329_at",0.682539393883246,0.150277787427467,-1.4901728922495,-4.9123716866207,-1.14895743093796,"EXTL1","exostosin like glycosyltransferase 1",TRUE
+"209537_at",0.746535697909741,0.238371772942362,1.21175309853998,-5.24874418631982,0.442705888173917,"EXTL2","exostosin like glycosyltransferase 2",TRUE
+"211051_s_at",0.631299908494113,0.102416647249068,1.70373942445836,-4.61687086155478,0.961241693449902,"EXTL3","exostosin like glycosyltransferase 3",TRUE
+"209202_s_at",0.776074974591224,0.293555632449894,1.07588339738952,-5.39109360473893,0.308540860989266,"EXTL3","exostosin like glycosyltransferase 3",TRUE
+"1556436_at",0.830592576740524,0.403142468516127,0.85234446427298,-5.59189890801634,0.396240371454802,"EXTL3-AS1","EXTL3 antisense RNA 1",TRUE
+"1569736_at",0.860662835518481,0.480192405989781,0.718112122257044,-5.6915860123316,0.45667291122816,"EYA1","EYA transcriptional coactivator and phosphatase 1",TRUE
+"214608_s_at",0.865677601761371,0.495662430113915,-0.692752527865683,-5.70860373112721,-0.698819089009608,"EYA1","EYA transcriptional coactivator and phosphatase 1",TRUE
+"209692_at",0.649509378726358,0.120065684330815,-1.61682693707654,-4.74082731994147,-2.31428553751373,"EYA2","EYA transcriptional coactivator and phosphatase 2",TRUE
+"1552314_a_at",0.552281323843226,0.0494757819973443,2.07822123367788,-4.03005547527478,0.911220492632531,"EYA3","EYA transcriptional coactivator and phosphatase 3",TRUE
+"206379_at",0.633854751673526,0.104790363061308,1.69134574533896,-4.63484775392848,1.29153026723779,"EYA3","EYA transcriptional coactivator and phosphatase 3",TRUE
+"226170_at",0.697699759202153,0.168414912368971,1.42387169068648,-4.99768755917859,0.488953458153047,"EYA3","EYA transcriptional coactivator and phosphatase 3",TRUE
+"1554844_at",0.737123149977386,0.223125419230386,-1.25340053054056,-5.20216529755241,-1.06213359362263,"EYA3","EYA transcriptional coactivator and phosphatase 3",TRUE
+"238877_at",0.328663980090165,0.00781459852066237,2.92444881625553,-2.4600113354286,3.195117437613,"EYA4","EYA transcriptional coactivator and phosphatase 4",TRUE
+"1561088_at",0.378119110146051,0.0115844430875517,2.75212708727471,-2.80093525425333,1.82462351292697,"EYA4","EYA transcriptional coactivator and phosphatase 4",TRUE
+"207327_at",0.635916735157933,0.107150047985257,1.67925916672089,-4.6522838161013,1.40753439031482,"EYA4","EYA transcriptional coactivator and phosphatase 4",TRUE
+"233996_x_at",0.961561244483099,0.825993933604926,-0.222459667230931,-5.91560825724692,-0.249823131063089,"EYS","eyes shut homolog (Drosophila)",TRUE
+"211310_at",0.376193411416669,0.0114799571016973,2.75613086994327,-2.79311499523162,2.27297066940489,"EZH1","enhancer of zeste 1 polycomb repressive complex 2 subunit",TRUE
+"239198_at",0.852409445602775,0.458260895594721,0.754896159132123,-5.6658691996173,0.276313777254584,"EZH1","enhancer of zeste 1 polycomb repressive complex 2 subunit",TRUE
+"32259_at",0.913300726876965,0.636439776057246,0.479274677347958,-5.82841810479205,0.186018726580482,"EZH1","enhancer of zeste 1 polycomb repressive complex 2 subunit",TRUE
+"203249_at",0.961212424803935,0.823181291086153,-0.226119633999438,-5.91481053877595,-0.143957045820578,"EZH1","enhancer of zeste 1 polycomb repressive complex 2 subunit",TRUE
+"239197_s_at",0.980264692225439,0.907973737479177,-0.1169239113961,-5.93302693571229,-0.0302002576401463,"EZH1","enhancer of zeste 1 polycomb repressive complex 2 subunit",TRUE
+"203358_s_at",0.632216562924782,0.103018685459888,-1.70057314545335,-4.62147289947832,-0.592428743593523,"EZH2","enhancer of zeste 2 polycomb repressive complex 2 subunit",TRUE
+"217230_at",0.135265250185742,0.000867153350972164,3.84666723642315,-0.530866697820009,2.54839726450032,"EZR","ezrin",TRUE
+"208621_s_at",0.462669793287247,0.0234264006323021,2.43432790242175,-3.40397538601025,1.19195330184518,"EZR","ezrin",TRUE
+"217234_s_at",0.468732760220321,0.0247444366516946,2.40899900223823,-3.45038658569509,1.05682487710356,"EZR","ezrin",TRUE
+"208622_s_at",0.468735421183467,0.0250202892095357,2.40385634468985,-3.45977717337795,1.21939544505916,"EZR","ezrin",TRUE
+"208623_s_at",0.498206796273596,0.0311527665042176,2.3012521966531,-3.64476464659065,0.817030320045879,"EZR","ezrin",TRUE
+"205620_at",0.487553723496951,0.0288033832078179,-2.33815804538921,-3.57875476252402,-1.40545938006231,"F10","coagulation factor X",TRUE
+"1569592_a_at",0.760227035076299,0.258037860572866,-1.16089980936213,-5.30376303984399,-0.984877222618584,"F11","coagulation factor XI",TRUE
+"206610_s_at",0.855405088766616,0.468449234156626,0.737681463871751,-5.6780562127077,0.392974492221795,"F11","coagulation factor XI",TRUE
+"1569591_at",0.978276691813018,0.895450668880889,-0.132927398300941,-5.93108088751625,-0.161104157878166,"F11","coagulation factor XI",TRUE
+"1563160_at",0.997654912087849,0.988380680728009,-0.0147284011991833,-5.93957782474129,-0.0101584662197065,"F11","coagulation factor XI",TRUE
+"1557233_at",0.838580722978591,0.423623220277434,0.815220167969995,-5.62107167486474,0.65375731242563,"F11-AS1","F11 antisense RNA 1",TRUE
+"222354_at",0.806312441670591,0.347182578908259,0.960472415125595,-5.50008343228902,0.435974722910105,"F11R","F11 receptor",TRUE
+"221664_s_at",0.896428361916712,0.58069226862125,0.560604764623327,-5.78775887340321,0.37945064169238,"F11R","F11 receptor",TRUE
+"223000_s_at",0.923392984964514,0.671217939935091,0.43018275617195,-5.84994868769027,0.315423627534281,"F11R","F11 receptor",TRUE
+"224097_s_at",0.975657122206595,0.883870115153293,0.147758038326853,-5.92905529649852,0.0931792471263986,"F11R","F11 receptor",TRUE
+"215961_at",0.800179799309599,0.335723323198079,-0.98403335975949,-5.47874396269049,-0.702516330081223,"F12","coagulation factor XII",TRUE
+"205774_at",0.83516820266233,0.414132036113868,-0.832279723864991,-5.60781686900757,-0.614661080860985,"F12","coagulation factor XII",TRUE
+"203305_at",0.925511384407886,0.677795869208792,0.421020753141518,-5.85371426435485,0.166660350384128,"F13A1","coagulation factor XIII A chain",TRUE
+"207810_at",0.822010986888098,0.385702835044226,0.884919510825781,-5.56530487142114,0.658856629413442,"F13B","coagulation factor XIII B chain",TRUE
+"205754_at",0.981213960355778,0.911331067596283,0.112638998512518,-5.93350573464342,0.0814472554165295,"F2","coagulation factor II, thrombin",TRUE
+"1569642_at",0.953983577550391,0.78850704716797,0.271517195841394,-5.90384006630504,0.226748824680269,"F2R","coagulation factor II thrombin receptor",TRUE
+"203989_x_at",0.972438691973544,0.867185438543558,0.169186003279759,-5.92575144156847,0.242431257205087,"F2R","coagulation factor II thrombin receptor",TRUE
+"213506_at",0.790240875783718,0.319604168215959,1.01813261214503,-5.44702784358265,1.09095402325169,"F2RL1","F2R like trypsin receptor 1",TRUE
+"206429_at",0.892780783477555,0.566041460509099,0.582605417257958,-5.77569874120151,0.413376935124782,"F2RL1","F2R like trypsin receptor 1",TRUE
+"206795_at",0.939356991756184,0.728439628066395,-0.351627504705865,-5.87964084391877,-0.272687118770351,"F2RL2","coagulation factor II thrombin receptor like 2",TRUE
+"230147_at",0.94943075115007,0.771421478337732,-0.294096743490355,-5.89764356421826,-0.34156193979145,"F2RL2","coagulation factor II thrombin receptor like 2",TRUE
+"207221_at",0.958813918694598,0.81371362250835,-0.23846304814184,-5.91202470908018,-0.184933547444619,"F2RL3","F2R like thrombin/trypsin receptor 3",TRUE
+"204363_at",0.304824368772306,0.00591989973969604,3.04419663328,-2.21832180522332,4.37956579748876,"F3","coagulation factor III, tissue factor",TRUE
+"231029_at",0.83872852514497,0.424096367963101,-0.814376033369658,-5.62172086501969,-0.590221524180746,"F5","coagulation factor V",TRUE
+"204713_s_at",0.91876780831279,0.654618151885443,0.453473205641344,-5.84001811961046,0.311277953311801,"F5","coagulation factor V",TRUE
+"204714_s_at",0.989586772349659,0.949621548817279,0.0639016577533732,-5.93769479221202,0.0501579953306592,"F5","coagulation factor V",TRUE
+"237414_at",0.819018525257656,0.375231012014945,-0.904942850831358,-5.54849931551255,-0.613577628604218,"F7","coagulation factor VII",TRUE
+"207300_s_at",0.945251068482575,0.752734965086245,-0.318972534891249,-5.89024912030217,-0.258990623278125,"F7","coagulation factor VII",TRUE
+"205756_s_at",0.954614142466984,0.793078841205961,-0.265500175769575,-5.90540843436897,-0.186972112083259,"F8","coagulation factor VIII",TRUE
+"203274_at",0.88113080359582,0.53727151505841,-0.626682479329592,-5.75018796267503,-0.272175788420522,"F8A3///F8A2///F8A1","coagulation factor VIII-associated 3///coagulation factor VIII-associated 2///coagulation factor VIII-associated 1",TRUE
+"207218_at",0.639705117673934,0.110187339490944,1.66402910896374,-4.67411966448163,1.09784535171254,"F9","coagulation factor IX",TRUE
+"234963_s_at",0.825056354800234,0.392482869267397,0.872144200918856,-5.57584500192119,0.552517384933636,"FA2H","fatty acid 2-hydroxylase",TRUE
+"219429_at",0.839026687117702,0.424720352886095,0.813263692179634,-5.62257535889663,0.741200623187149,"FA2H","fatty acid 2-hydroxylase",TRUE
+"204231_s_at",0.825971419451151,0.393535536839552,-0.87017359221102,-5.57745816075471,-0.548408612872524,"FAAH","fatty acid amide hydrolase",TRUE
+"230792_at",0.996168756168935,0.980910588477779,-0.0241988845670878,-5.93939826741678,-0.0126067417764055,"FAAH2","fatty acid amide hydrolase 2",TRUE
+"228136_s_at",0.817815704063733,0.370357436760803,0.91438740701555,-5.54045195765224,0.45027361347316,"FAAP100","Fanconi anemia core complex associated protein 100",TRUE
+"221800_s_at",0.841175185633249,0.431054989288997,-0.802028517063153,-5.63114468861905,-0.232117835038547,"FAAP100","Fanconi anemia core complex associated protein 100",TRUE
+"225322_s_at",0.899998627338565,0.594386725678841,-0.54029027398198,-5.79849463890412,-0.302203630719116,"FAAP100","Fanconi anemia core complex associated protein 100",TRUE
+"1558544_at",0.617775129514679,0.0888046142234024,1.779949264275,-4.50418845061174,0.726472366929749,"FAAP20","Fanconi anemia core complex associated protein 20",TRUE
+"1562675_at",0.668518995965071,0.134746744311813,-1.55234867997547,-4.82953781947055,-0.576121674751375,"FAAP20","Fanconi anemia core complex associated protein 20",TRUE
+"228197_at",0.725583196024696,0.204606784360515,-1.30702604740575,-5.14020878644669,-0.740617738962531,"FAAP20","Fanconi anemia core complex associated protein 20",TRUE
+"229113_s_at",0.773107052530371,0.283974557585138,1.09804506255402,-5.36889641011431,0.322570379995932,"FAAP20","Fanconi anemia core complex associated protein 20",TRUE
+"1556309_s_at",0.884359306770494,0.543539280195989,-0.616975826469289,-5.75595997151595,-0.56322775267991,"FAAP20","Fanconi anemia core complex associated protein 20",TRUE
+"236498_s_at",0.888750194607196,0.555449378383478,0.598693357270706,-5.76659552260889,0.339857195477389,"FAAP20","Fanconi anemia core complex associated protein 20",TRUE
+"236499_at",0.956938436670832,0.80463330261653,0.250337123575739,-5.90920589180805,0.177618398966367,"FAAP20","Fanconi anemia core complex associated protein 20",TRUE
+"230649_at",0.979388236370534,0.900839927131075,-0.126036245995454,-5.93194937753708,-0.0417683826227444,"FAAP20","Fanconi anemia core complex associated protein 20",TRUE
+"236584_at",0.984244246588495,0.923316560224017,-0.0973591098825402,-5.93506776288991,-0.0867364402098283,"FAAP20","Fanconi anemia core complex associated protein 20",TRUE
+"214816_x_at",0.936740403714722,0.717353830883135,-0.366656036259145,-5.87441563128385,-0.0953637693550125,"FAAP24","Fanconi anemia core complex associated protein 24",TRUE
+"231693_at",0.895583942835671,0.574795356891569,0.569425775891248,-5.78297746651609,0.329587849497956,"FABP1","fatty acid binding protein 1",TRUE
+"205892_s_at",0.936992192746977,0.718603457851033,-0.364957727924834,-5.87501693028598,-0.153202701218815,"FABP1","fatty acid binding protein 1",TRUE
+"207475_at",0.899331416659389,0.589804312548333,0.547061882556394,-5.79495875307968,0.449224717411303,"FABP2","fatty acid binding protein 2",TRUE
+"205738_s_at",0.925511384407886,0.677899756548715,-0.420876350283168,-5.85377297606472,-0.29375912889593,"FABP3","fatty acid binding protein 3",TRUE
+"214285_at",0.947778780715578,0.762119412624193,-0.306455132410929,-5.8940443056239,-0.207488631137355,"FABP3","fatty acid binding protein 3",TRUE
+"216569_at",0.632949074657601,0.104028152859773,-1.6952991931943,-4.62912405094179,-0.970857503755785,"FABP3P2","fatty acid binding protein 3 pseudogene 2",TRUE
+"203980_at",0.721317419960934,0.197533810044519,1.32850278250404,-5.11477893620522,1.30828064590412,"FABP4","fatty acid binding protein 4",TRUE
+"235978_at",0.959969342594555,0.818928030677553,-0.231660235569811,-5.91357827621647,-0.185521793006929,"FABP4","fatty acid binding protein 4",TRUE
+"202345_s_at",0.710842845257879,0.184250207355424,1.37052225397559,-5.06402018101854,2.85435676548661,"FABP5","fatty acid binding protein 5",TRUE
+"210445_at",0.316920685370514,0.00687776462570992,2.97968790624518,-2.34897187409623,2.7967076326575,"FABP6","fatty acid binding protein 6",TRUE
+"1566124_a_at",0.51531387545335,0.0355528035038222,2.23851505800778,-3.75556006664171,1.4396893066477,"FABP6","fatty acid binding protein 6",TRUE
+"1566123_at",0.819193107051406,0.37569600941817,0.904045976496649,-5.54925949801212,0.342925025585563,"FABP6","fatty acid binding protein 6",TRUE
+"205029_s_at",0.914776697425609,0.640934636319642,-0.472864796442218,-5.83135855635646,-0.968643062211252,"FABP7","fatty acid binding protein 7",TRUE
+"216192_at",0.967106491969364,0.846635570431377,0.195691035233062,-5.92104860124848,0.188791492108751,"FABP7","fatty acid binding protein 7",TRUE
+"205030_at",0.996771621728225,0.98367269343713,0.020696907647723,-5.93947484357292,0.0322173321789911,"FABP7","fatty acid binding protein 7",TRUE
+"202535_at",0.998870448604467,0.995148908791878,0.00614894786608536,-5.9396650651233,0.00385376901815881,"FADD","Fas associated via death domain",TRUE
+"243953_at",0.556381379241158,0.0519146075663397,-2.05443963306818,-4.06967162241452,-1.45267411009133,"FADS2","fatty acid desaturase 2",TRUE
+"202218_s_at",0.966111788889917,0.842315187281088,0.201281068491222,-5.91996981479044,0.247541616163009,"FADS2","fatty acid desaturase 2",TRUE
+"216080_s_at",0.957174671135192,0.806215051762558,-0.248266116690253,-5.90970733599012,-0.17249883140591,"FADS3","fatty acid desaturase 3",TRUE
+"204257_at",0.978928101156583,0.897496232206771,0.130311013698062,-5.93141606402402,0.0639923741775181,"FADS3","fatty acid desaturase 3",TRUE
+"239749_at",0.69097068180963,0.160676703443302,1.45141643111768,-4.96262638652783,0.391967790085135,"FAF1","Fas associated factor 1",TRUE
+"236200_at",0.91876780831279,0.65484655373443,-0.45315104008626,-5.84015898647764,-0.16845376670983,"FAF1","Fas associated factor 1",TRUE
+"218080_x_at",0.964181293782946,0.83555619414145,-0.210039609429271,-5.91821870817954,-0.0549656782034056,"FAF1","Fas associated factor 1",TRUE
+"224217_s_at",0.994217597763908,0.97373244327099,-0.0333013680597022,-5.93914335137102,-0.00789586503488771,"FAF1","Fas associated factor 1",TRUE
+"222511_x_at",0.998597141250502,0.993939760893504,-0.00768161848877292,-5.93965474052792,-0.00262735979514694,"FAF1","Fas associated factor 1",TRUE
+"212108_at",0.358427723880268,0.0101436608499355,-2.81063115816403,-2.68616997160481,-0.745869773109273,"FAF2","Fas associated factor family member 2",TRUE
+"212106_at",0.96569241146864,0.839582785169855,0.204819832407341,-5.91927124717719,0.0563956169502013,"FAF2","Fas associated factor family member 2",TRUE
+"236481_at",0.663819586595936,0.131802949776025,-1.56479303207667,-4.81263688150624,-1.07512117374115,"FAH","fumarylacetoacetate hydrolase",TRUE
+"202862_at",0.762209577303903,0.26159081839123,-1.15202292002724,-5.31315542343102,-0.582049105367423,"FAH","fumarylacetoacetate hydrolase",TRUE
+"227960_s_at",0.534873540719944,0.0425369387921533,-2.15215121036403,-3.90503791945651,-0.711901819146023,"FAHD1","fumarylacetoacetate hydrolase domain containing 1",TRUE
+"226767_s_at",0.577452268836288,0.06154210096953,-1.96935550512187,-4.20892879971131,-0.582796500840727,"FAHD1","fumarylacetoacetate hydrolase domain containing 1",TRUE
+"218504_at",0.750807729565285,0.243816206918892,1.19736942883511,-5.26451438296396,0.402370489659049,"FAHD2A","fumarylacetoacetate hydrolase domain containing 2A",TRUE
+"222056_s_at",0.769424525862551,0.276852102373918,1.11487270475145,-5.35177307888003,0.319362338368542,"FAHD2A","fumarylacetoacetate hydrolase domain containing 2A",TRUE
+"235621_at",0.986421906591669,0.936497780748761,0.0805820616210576,-5.93652124641522,0.0609173880579323,"FAHD2A","fumarylacetoacetate hydrolase domain containing 2A",TRUE
+"235418_at",0.993461753950386,0.969061713727816,-0.0392257402043842,-5.93893408461651,-0.0173136546615815,"FAHD2A","fumarylacetoacetate hydrolase domain containing 2A",TRUE
+"1562938_at",0.68041487556515,0.148166794851004,-1.49830541941355,-4.90169096224238,-1.1066095315868,"FAHD2CP","fumarylacetoacetate hydrolase domain containing 2C, pseudogene",TRUE
+"228199_at",0.819479221404744,0.376658075635538,-0.902192692428451,-5.55082811816955,-0.505741117420315,"FAHD2CP","fumarylacetoacetate hydrolase domain containing 2C, pseudogene",TRUE
+"228198_s_at",0.896229101808264,0.579958451935487,-0.56169999898808,-5.78716914064157,-0.366198565927893,"FAHD2CP","fumarylacetoacetate hydrolase domain containing 2C, pseudogene",TRUE
+"222055_at",0.493378740589161,0.0297525449255815,2.32292654714229,-3.60607120253567,1.44187943194436,"FAHD2CP///FAHD2B///FAHD2A","fumarylacetoacetate hydrolase domain containing 2C, pseudogene///fumarylacetoacetate hydrolase domain containing 2B///fumarylacetoacetate hydrolase domain containing 2A",TRUE
+"220643_s_at",0.849935057946582,0.451841643716116,0.765860346129895,-5.6579685266957,0.293634184148541,"FAIM","Fas apoptotic inhibitory molecule",TRUE
+"203619_s_at",0.853460708803218,0.461943533462496,-0.748647723731867,-5.67032352286232,-0.740245138060854,"FAIM2","Fas apoptotic inhibitory molecule 2",TRUE
+"203618_at",0.913054586825583,0.634904843832133,0.481468222926073,-5.82740295007971,0.126039826256498,"FAIM2","Fas apoptotic inhibitory molecule 2",TRUE
+"226905_at",0.606339206711271,0.0800134865372075,1.83470081008937,-4.42101499149566,2.55246893904025,"FAM101B","family with sequence similarity 101 member B",TRUE
+"226876_at",0.643309828661823,0.11376004515532,1.64656136893927,-4.6989770910146,1.3457645224607,"FAM101B","family with sequence similarity 101 member B",TRUE
+"212400_at",0.609499207369658,0.081698629017525,-1.82381538355896,-4.4376958335283,-0.996250888248227,"FAM102A","family with sequence similarity 102 member A",TRUE
+"228428_at",0.99659046136788,0.982976006760863,0.0215801856977775,-5.93945665584464,0.0131073864639486,"FAM102A","family with sequence similarity 102 member A",TRUE
+"226568_at",0.812896635201594,0.361870828161661,-0.931032837344711,-5.52608163729478,-0.720821605534587,"FAM102B","family with sequence similarity 102 member B",TRUE
+"225210_s_at",0.769258076576208,0.276558168506032,-1.11557388668321,-5.35105456327675,-0.411273961751776,"FAM103A1","family with sequence similarity 103 member A1",TRUE
+"225208_s_at",0.819479221404744,0.376608867709414,-0.902287408701241,-5.55074802241501,-0.317712183032477,"FAM103A1","family with sequence similarity 103 member A1",TRUE
+"229087_s_at",0.808257777979515,0.350410243065114,-0.953932077696295,-5.50592329714877,-0.563890864299545,"FAM104A","family with sequence similarity 104 member A",TRUE
+"225319_s_at",0.980452972720563,0.908741378062867,-0.115943987803602,-5.9331380074051,-0.0451898593263049,"FAM104A","family with sequence similarity 104 member A",TRUE
+"232990_at",0.597346378847428,0.0734327080311473,-1.87921575173037,-4.35206589407259,-1.35622794647378,"FAM104B","family with sequence similarity 104 member B",TRUE
+"227869_at",0.698955864196462,0.170300969117,-1.41731265901061,-5.00595531728626,-0.45185282051269,"FAM104B","family with sequence similarity 104 member B",TRUE
+"244650_at",0.28785267911226,0.00491769038630052,3.12347525308757,-2.05641403455569,1.48777133177324,"FAM105A","family with sequence similarity 105 member A",TRUE
+"219694_at",0.358427723880268,0.0100557527552681,2.81445163695432,-2.67863922815071,2.098505297978,"FAM105A","family with sequence similarity 105 member A",TRUE
+"214947_at",0.673622120503302,0.139985721566216,1.53074645224822,-4.85862282359196,0.953498221846316,"FAM105A","family with sequence similarity 105 member A",TRUE
+"220575_at",0.987878312181854,0.942113307805678,-0.0734421011546383,-5.93705672920872,-0.047956680638686,"FAM106A","family with sequence similarity 106 member A",TRUE
+"207547_s_at",0.968451827985008,0.851785294154502,0.18903624825943,-5.92229339726785,0.147096891568623,"FAM107A","family with sequence similarity 107 member A",TRUE
+"209074_s_at",0.994683443051162,0.975271879562628,0.0313490191269445,-5.93920482543617,0.0188843544321244,"FAM107A","family with sequence similarity 107 member A",TRUE
+"223058_at",0.771534633613556,0.280875446618966,1.10532898561068,-5.36151287915158,0.72475232190118,"FAM107B","family with sequence similarity 107 member B",TRUE
+"223059_s_at",0.791211889207316,0.32128812538556,1.01451512455772,-5.4504389297256,0.695606081562754,"FAM107B","family with sequence similarity 107 member B",TRUE
+"229690_at",0.85334340854827,0.460221495763043,0.751565830871048,-5.66824765390612,0.580107598994201,"FAM109A","family with sequence similarity 109 member A",TRUE
+"226504_at",0.979976490833035,0.904574737498336,0.12126429270287,-5.9325237405174,0.0921833943844046,"FAM109B","family with sequence similarity 109 member B",TRUE
+"226584_s_at",0.699684100574767,0.171144243664346,-1.41439886115561,-5.00961814415084,-0.931259431857663,"FAM110A","family with sequence similarity 110 member A",TRUE
+"221959_at",0.657015752622694,0.12597438503441,-1.59012766478131,-4.77790249744373,-1.87095577345486,"FAM110B","family with sequence similarity 110 member B",TRUE
+"228790_at",0.955816406528307,0.798711960016168,-0.258100048283499,-5.90728944553199,-0.277076114719547,"FAM110B","family with sequence similarity 110 member B",TRUE
+"227800_at",0.992376456171815,0.964525998609451,-0.0449802348485045,-5.938698092184,-0.0310535859337993,"FAM110B","family with sequence similarity 110 member B",TRUE
+"226863_at",0.890298025358508,0.558604001095997,0.593885414000521,-5.76934116715324,0.593173905243667,"FAM110C","family with sequence similarity 110 member C",TRUE
+"220430_at",0.773234064853267,0.284149089585732,-1.09763657105904,-5.36930920244088,-0.623847431669986,"FAM110D","family with sequence similarity 110 member D",TRUE
+"218248_at",0.924029559540466,0.673205389267989,-0.427410645217378,-5.8510964273457,-0.188868956989397,"FAM111A","family with sequence similarity 111 member A",TRUE
+"229196_at",0.939389447806415,0.728609249687191,-0.351398204856361,-5.87971889528884,-0.315842211474001,"FAM111A","family with sequence similarity 111 member A",TRUE
+"1557128_at",0.927751423245943,0.682930085828781,0.413895026461737,-5.85658783778644,0.211886712776526,"FAM111B","family with sequence similarity 111 member B",TRUE
+"1557129_a_at",0.990810941805126,0.955099809603401,0.0569445195478686,-5.93810421511426,0.0294582164081847,"FAM111B","family with sequence similarity 111 member B",TRUE
+"213455_at",0.463114681277637,0.0235559566279489,2.43178048151437,-3.40865509162036,1.86241226471424,"FAM114A1","family with sequence similarity 114 member A1",TRUE
+"226697_at",0.591331966259927,0.0688128644332673,1.91259766299534,-4.29959875540792,1.02605151030131,"FAM114A1","family with sequence similarity 114 member A1",TRUE
+"222682_s_at",0.634202341398092,0.105046677977944,-1.69002176679134,-4.6367623253492,-0.588412899434257,"FAM114A2","family with sequence similarity 114 member A2",TRUE
+"218588_s_at",0.736330422786726,0.221867192603016,-1.25693334943166,-5.19815188887701,-0.526380790088732,"FAM114A2","family with sequence similarity 114 member A2",TRUE
+"221249_s_at",0.709914655587487,0.182814397980549,-1.37520578287702,-5.05828089693685,-0.733328255274,"FAM117A","family with sequence similarity 117 member A",TRUE
+"243186_at",0.823074246722209,0.389596533571884,0.877565106291304,-5.57138991566208,0.279222211712851,"FAM117B","family with sequence similarity 117 member B",TRUE
+"226431_at",0.937735933140623,0.724442475287775,-0.357036577935182,-5.87778506066737,-0.154563399115538,"FAM117B","family with sequence similarity 117 member B",TRUE
+"1553220_at",0.94895689004559,0.768820762229669,0.297547170776477,-5.89665343918039,0.0970471127579575,"FAM117B","family with sequence similarity 117 member B",TRUE
+"1564868_a_at",0.955735662836499,0.797918363450134,0.259141681415279,-5.90702787097295,0.0994320493796499,"FAM117B","family with sequence similarity 117 member B",TRUE
+"226475_at",0.893172664248402,0.567460135523285,0.580462471268504,-5.77689320448905,0.276937873276284,"FAM118A","family with sequence similarity 118 member A",TRUE
+"219629_at",0.913895480987494,0.638715576030985,0.476026751202894,-5.82991289060327,0.193377285381903,"FAM118A","family with sequence similarity 118 member A",TRUE
+"223386_at",0.757046717164774,0.252751821403715,-1.17427597749539,-5.28949078137183,-0.501466785568381,"FAM118B","family with sequence similarity 118 member B",TRUE
+"239318_at",0.774230543658252,0.288319540224859,-1.08792912442007,-5.37907861375193,-0.336934606826282,"FAM118B","family with sequence similarity 118 member B",TRUE
+"230009_at",0.94632739401154,0.757065520484766,-0.313189904390378,-5.89202107377218,-0.139456034672421,"FAM118B","family with sequence similarity 118 member B",TRUE
+"1555944_at",0.652199141379004,0.121332201524382,1.61101307541653,-4.74894134571516,0.782410701754428,"FAM120A","family with sequence similarity 120A",TRUE
+"200767_s_at",0.895657764833717,0.575150511886151,0.568893223665366,-5.78326818768862,0.154803150797637,"FAM120A","family with sequence similarity 120A",TRUE
+"1555908_at",0.93613089056626,0.714619508545656,-0.37037596643917,-5.87308893428446,-0.178196446410807,"FAM120A","family with sequence similarity 120A",TRUE
+"1555945_s_at",0.940938843113333,0.735470949642944,0.342138270740328,-5.88282883026707,0.111433594929796,"FAM120A","family with sequence similarity 120A",TRUE
+"1559711_at",0.943988850936011,0.749222923223008,0.323670349914257,-5.88878595214839,0.204867162923711,"FAM120A","family with sequence similarity 120A",TRUE
+"210516_at",0.954804534580187,0.794407938133239,0.263752814665684,-5.90585735291437,0.156428215293761,"FAM120A","family with sequence similarity 120A",TRUE
+"1555947_at",0.98539961718117,0.928054413350734,0.0913257347913121,-5.93562200068054,0.0310233380237968,"FAM120A","family with sequence similarity 120A",TRUE
+"1555948_s_at",0.98539961718117,0.92836726709955,-0.090927458815509,-5.93565734102006,-0.0306463495194773,"FAM120A","family with sequence similarity 120A",TRUE
+"200774_at",0.994083192910649,0.972520200314756,-0.0348388557673415,-5.9390923271769,-0.00886643141502041,"FAM120A","family with sequence similarity 120A",TRUE
+"239391_at",0.0681210092794308,0.000185642988251215,-4.47636223612023,0.828116573063935,-1.93832481487151,"FAM120AOS","family with sequence similarity 120A opposite strand",TRUE
+"225395_s_at",0.657571067962164,0.12626848842667,-1.58882621193397,-4.77969744366167,-0.69140323555644,"FAM120AOS","family with sequence similarity 120A opposite strand",TRUE
+"230308_at",0.678126513742682,0.145392500733291,-1.50913839957473,-4.88739126611755,-1.04957647425389,"FAM120AOS","family with sequence similarity 120A opposite strand",TRUE
+"1558761_a_at",0.753606468220283,0.246854923482227,-1.18944608450211,-5.2731315460491,-0.495059890657647,"FAM120AOS","family with sequence similarity 120A opposite strand",TRUE
+"227895_at",0.851019188786532,0.454134983278173,-0.761932579748204,-5.66081121386115,-0.363023461173842,"FAM120B","family with sequence similarity 120B",TRUE
+"226774_at",0.94118897722809,0.736573741999854,0.340652903172123,-5.88332004725662,0.134690911465944,"FAM120B","family with sequence similarity 120B",TRUE
+"229512_at",0.491581666454407,0.0294462157982216,-2.32779289621568,-3.59735494276987,-1.37294840825182,"FAM120C","family with sequence similarity 120C",TRUE
+"220685_at",0.847311733573803,0.446006189272694,0.775909364640601,-5.65063280895788,0.411288825524314,"FAM120C","family with sequence similarity 120C",TRUE
+"235424_at",0.388809096545805,0.0128927460820767,-2.70469656965096,-2.89318719145988,-1.25520900270593,"FAM122A","family with sequence similarity 122A",TRUE
+"235043_at",0.406164654174876,0.0153553360343,-2.62660148243318,-3.04345307290201,-0.972079660242987,"FAM122A","family with sequence similarity 122A",TRUE
+"226443_at",0.593337376134677,0.0700376249110775,-1.90356094026985,-4.31386564191597,-0.627623976587792,"FAM122A","family with sequence similarity 122A",TRUE
+"225362_at",0.843753336849204,0.439131314783215,0.787851614354907,-5.64179779413746,0.360222864442228,"FAM122B","family with sequence similarity 122B",TRUE
+"222673_x_at",0.976589025744684,0.888691548000018,0.141579540520255,-5.92992512751741,0.141293563773983,"FAM122B","family with sequence similarity 122B",TRUE
+"225361_x_at",0.981140604770329,0.910909314637854,0.113177155525307,-5.93344658086597,0.102138589770192,"FAM122B","family with sequence similarity 122B",TRUE
+"1552322_at",0.774230543658252,0.289521418056577,1.08515035787036,-5.38186088050259,0.769206451674168,"FAM122C","family with sequence similarity 122C",TRUE
+"1552323_s_at",0.7768734672127,0.29499074227197,1.07260885990806,-5.39433912783504,0.517324404412904,"FAM122C","family with sequence similarity 122C",TRUE
+"1562641_at",0.812302873476553,0.359855111118388,0.935024678850309,-5.52259995623583,0.791523180005141,"FAM122C","family with sequence similarity 122C",TRUE
+"239047_at",0.965580083724105,0.838902334468449,0.205701506051572,-5.91909531401744,0.123980542934534,"FAM122C","family with sequence similarity 122C",TRUE
+"241013_at",0.62110896023334,0.0914687116057256,-1.76428125128055,-4.52765195976861,-1.08883025414615,"FAM124A","family with sequence similarity 124 member A",TRUE
+"1553239_at",0.760905446901853,0.259952142925319,1.15610591373119,-5.3088431860117,0.54662284537813,"FAM124A","family with sequence similarity 124 member A",TRUE
+"230067_at",0.873665367559788,0.519193378624334,0.655027269094686,-5.73283709200699,0.561427522821653,"FAM124A","family with sequence similarity 124 member A",TRUE
+"230519_at",0.89037721023972,0.558888328302237,0.593452767131652,-5.76958718710019,0.394024072995264,"FAM124A","family with sequence similarity 124 member A",TRUE
+"241829_at",0.98276043839152,0.916164600728227,-0.106473798863072,-5.93416331489764,-0.105224465303566,"FAM124A","family with sequence similarity 124 member A",TRUE
+"220637_at",0.995111934465262,0.977083751559455,-0.0290513202786246,-5.93927241795374,-0.0131239652499446,"FAM124B","family with sequence similarity 124 member B",TRUE
+"223625_at",0.59373946572406,0.0706080293760921,1.89939950819775,-4.32041974430365,2.35718015321556,"FAM126A","family with sequence similarity 126 member A",TRUE
+"231396_s_at",0.627092759817312,0.0988069293979051,1.72306307798588,-4.58864595450461,1.27251434350673,"FAM126A","family with sequence similarity 126 member A",TRUE
+"244115_at",0.637485146909712,0.108575760531492,1.67206530052638,-4.66261672131697,1.48758033173143,"FAM126A","family with sequence similarity 126 member A",TRUE
+"227239_at",0.637485146909712,0.10872771133889,1.67130330536909,-4.66370924175903,2.43604065960687,"FAM126A","family with sequence similarity 126 member A",TRUE
+"229460_at",0.527826453640453,0.0403816963903367,-2.17733752072272,-3.86181981913265,-0.675531201002498,"FAM126B","family with sequence similarity 126 member B",TRUE
+"1558959_at",0.568782381584554,0.0587247653231789,-1.99295328199088,-4.1707011979539,-0.605001496212375,"FAM126B","family with sequence similarity 126 member B",TRUE
+"1554178_a_at",0.689913893405055,0.159107739910817,-1.45713119990602,-4.95528362666221,-0.574475816698625,"FAM126B","family with sequence similarity 126 member B",TRUE
+"231874_at",0.865345395265289,0.495181735375676,-0.693533614032775,-5.70808828749233,-0.274143174036245,"FAM126B","family with sequence similarity 126 member B",TRUE
+"201828_x_at",0.739938131186072,0.228348899634249,-1.23889485744781,-5.21854250966178,-0.492649962393404,"FAM127A","family with sequence similarity 127 member A",TRUE
+"217948_at",0.751773688468537,0.245022535500856,-1.1942151567265,-5.2679508296124,-0.578310342228129,"FAM127B","family with sequence similarity 127 member B",TRUE
+"217966_s_at",0.359661276493392,0.0102401214032229,2.80647504100256,-2.69435734574587,2.08717179946022,"FAM129A","family with sequence similarity 129 member A",TRUE
+"217967_s_at",0.42327301158031,0.0177314774803903,2.5617060702277,-3.16669424697653,2.913130778929,"FAM129A","family with sequence similarity 129 member A",TRUE
+"233974_s_at",0.850456140089191,0.453094410693334,0.763713264955992,-5.65952416999676,0.379225901292314,"FAM129B","family with sequence similarity 129 member B",TRUE
+"223019_at",0.957813759927439,0.810354450197227,-0.24285156602793,-5.9109987708051,-0.130046760969837,"FAM129B","family with sequence similarity 129 member B",TRUE
+"1569422_at",0.590570903980459,0.0683326683480223,1.91617928579593,-4.29393121750255,0.957527606355653,"FAM129C","family with sequence similarity 129 member C",TRUE
+"230983_at",0.933185163890644,0.704595334901392,0.384059552127524,-5.86809507015467,0.138728338875303,"FAM129C","family with sequence similarity 129 member C",TRUE
+"1553369_at",0.966593471043185,0.844775896944674,0.198096426556708,-5.92058810932324,0.130228937499018,"FAM129C","family with sequence similarity 129 member C",TRUE
+"221904_at",0.581900527598516,0.0641873266016763,-1.94805358529464,-4.24317144985536,-1.29391554898068,"FAM131A","family with sequence similarity 131 member A",TRUE
+"232806_s_at",0.807051198331174,0.34821085716351,-0.958384310603966,-5.50195186703713,-0.514832781860886,"FAM131A","family with sequence similarity 131 member A",TRUE
+"232807_at",0.833947935066508,0.411698987090329,0.836692538714152,-5.6043464309946,0.26907793885352,"FAM131A","family with sequence similarity 131 member A",TRUE
+"205368_at",0.843816788557882,0.439695022937506,0.786868116333034,-5.64253020168051,0.614930871245616,"FAM131B","family with sequence similarity 131 member B",TRUE
+"235455_at",0.655235030401569,0.123948121366546,1.59916361529455,-4.76540867704849,1.16137294171885,"FAM131C","family with sequence similarity 131 member C",TRUE
+"243292_at",0.795662914172144,0.327887100902603,1.00046519671302,-5.46358288958307,0.654937215197403,"FAM132A","family with sequence similarity 132 member A",TRUE
+"239481_at",0.961956856291791,0.827080564378981,0.221046517417637,-5.91591279760544,0.100310861873799,"FAM133A","family with sequence similarity 133 member A",TRUE
+"231131_at",0.992784989582189,0.96582646697533,0.0433301707672608,-5.93876905929428,0.0378728343528705,"FAM133A","family with sequence similarity 133 member A",TRUE
+"226332_at",0.622917527985155,0.0935924323591476,-1.75206963394784,-4.54583361540151,-0.435609277453176,"FAM133DP///FAM133B","family with sequence similarity 133, member A pseudogene///family with sequence similarity 133 member B",TRUE
+"235469_at",0.994050962712312,0.972123256270411,0.0353423184084162,-5.9390751185048,0.0128862647963244,"FAM133DP///FAM133B","family with sequence similarity 133, member A pseudogene///family with sequence similarity 133 member B",TRUE
+"221984_s_at",0.682825347106105,0.151004298101363,-1.48739557081818,-4.9160085299631,-0.560366835410989,"FAM134A","family with sequence similarity 134 member A",TRUE
+"218037_at",0.720021194788968,0.196080514176993,-1.33298979591493,-5.10942192821107,-0.465428428396441,"FAM134A","family with sequence similarity 134 member A",TRUE
+"221983_at",0.94895689004559,0.768826353453685,-0.297539748834957,-5.89665558124938,-0.118646595874079,"FAM134A","family with sequence similarity 134 member A",TRUE
+"222129_at",0.979124488698146,0.898681375698931,0.128795579267093,-5.93160715916698,0.0532110644191714,"FAM134A","family with sequence similarity 134 member A",TRUE
+"213663_s_at",0.76912869907427,0.274675907338767,1.12007696317899,-5.34643063238498,1.07276037682197,"FAM134B","family with sequence similarity 134 member B",TRUE
+"218510_x_at",0.891313222878521,0.560626643526152,0.59081013677598,-5.77108612775513,0.51568489214562,"FAM134B","family with sequence similarity 134 member B",TRUE
+"213662_at",0.958733377455711,0.812910719775706,-0.239511544411673,-5.91178128539455,-0.141998960054764,"FAM134B","family with sequence similarity 134 member B",TRUE
+"218532_s_at",0.98672253748883,0.938126115303037,0.0785112620065538,-5.9366816606215,0.0671169018975419,"FAM134B","family with sequence similarity 134 member B",TRUE
+"212697_at",0.865677601761371,0.495640138073397,-0.692788740885243,-5.70857984618748,-0.226112134227447,"FAM134C","family with sequence similarity 134 member C",TRUE
+"233730_at",0.64513208805899,0.115968052149862,1.63599551690424,-4.71391532803706,1.40232601964489,"FAM135A","family with sequence similarity 135 member A",TRUE
+"223497_at",0.71664087863316,0.192611572227056,1.34380635437883,-5.09644577225857,1.67854138791793,"FAM135A","family with sequence similarity 135 member A",TRUE
+"221233_s_at",0.91709323258454,0.648984988786986,-0.461434448245991,-5.8365058977199,-0.418337231643436,"FAM135A","family with sequence similarity 135 member A",TRUE
+"236786_at",0.528056136690037,0.0405708653679055,2.17507878622882,-3.8657084123674,0.874334104218032,"FAM135B","family with sequence similarity 135 member B",TRUE
+"1557838_at",0.934048461921637,0.707926385995214,-0.379504313657779,-5.86977735661368,-0.308788846257563,"FAM135B","family with sequence similarity 135 member B",TRUE
+"224001_at",0.992820830895496,0.966122884405788,0.0429540869567245,-5.93878486312983,0.0118426838254644,"FAM135B","family with sequence similarity 135 member B",TRUE
+"1555822_at",0.955645941042265,0.796857726451499,-0.260534275574087,-5.90667652807503,-0.165135175297488,"FAM138E///FAM138D///FAM138C///FAM138B///FAM138A///FAM138F","family with sequence similarity 138 member E///family with sequence similarity 138 member D///family with sequence similarity 138 member C///family with sequence similarity 138 member B///family with sequence similarity 138 member A///family with sequence similarity 138 member F",TRUE
+"1569024_at",0.631360647647282,0.102724600873303,1.702117844067,-4.6192285558035,0.855719535402739,"FAM13A","family with sequence similarity 13 member A",TRUE
+"1569025_s_at",0.663789119801086,0.131648286884201,1.56545317678226,-4.81173735947124,1.40759877351393,"FAM13A","family with sequence similarity 13 member A",TRUE
+"202972_s_at",0.768852835478002,0.273017431621608,1.12406336198566,-5.34232348946469,0.555841716489226,"FAM13A","family with sequence similarity 13 member A",TRUE
+"217047_s_at",0.778006206647445,0.297133804265284,1.06774012973797,-5.39914835696477,0.867106817242275,"FAM13A","family with sequence similarity 13 member A",TRUE
+"202973_x_at",0.7974001826642,0.330617781268994,0.9947087050106,-5.46892016257424,0.761599832544023,"FAM13A","family with sequence similarity 13 member A",TRUE
+"1558711_at",0.885667133725284,0.547323660069683,-0.61114394540453,-5.75938610192407,-0.357389361498021,"FAM13A-AS1","FAM13A antisense RNA 1",TRUE
+"243020_at",0.908709061737317,0.62046574000128,0.502222538556192,-5.81757388895622,0.288897841949964,"FAM13A-AS1","FAM13A antisense RNA 1",TRUE
+"218518_at",0.848268984089208,0.448112538956536,-0.772272948164346,-5.65329779214152,-0.29707377295161,"FAM13B","family with sequence similarity 13 member B",TRUE
+"214914_at",0.69887421412603,0.170214114025314,-1.41761342833356,-5.00557687870716,-1.25910683512419,"FAM13C","family with sequence similarity 13 member C",TRUE
+"1554547_at",0.897560972979555,0.584451869128078,-0.555004310788847,-5.790756999411,-0.78056162104127,"FAM13C","family with sequence similarity 13 member C",TRUE
+"222291_at",0.740476003158683,0.229500568605493,1.23573074160622,-5.22209306686686,0.873319220519621,"FAM149A","family with sequence similarity 149 member A",TRUE
+"214889_at",0.88020017258149,0.535398493763005,-0.62959492249577,-5.74843917351061,-0.461119729057989,"FAM149A","family with sequence similarity 149 member A",TRUE
+"214890_s_at",0.990918916504081,0.957404925774254,0.0540180094663302,-5.938262357087,0.0482262261602431,"FAM149A","family with sequence similarity 149 member A",TRUE
+"213458_at",0.716245563733659,0.192003374638066,1.34571850826929,-5.09414269572381,1.07193180169094,"FAM149B1","family with sequence similarity 149 member B1",TRUE
+"238859_at",0.740681080735184,0.23102679616898,1.23155610345112,-5.22676558901618,0.426892886264011,"FAM149B1","family with sequence similarity 149 member B1",TRUE
+"213463_s_at",0.773107052530371,0.283923496184031,-1.09816460591655,-5.36877558229198,-0.35654909074911,"FAM149B1","family with sequence similarity 149 member B1",TRUE
+"213896_x_at",0.798428326317339,0.332753159779604,0.990230030808043,-5.4730533207151,0.551924223507237,"FAM149B1","family with sequence similarity 149 member B1",TRUE
+"238018_at",0.691497416459637,0.161164500800805,1.44964887202166,-4.96489272580882,1.36659277920498,"FAM150B","family with sequence similarity 150 member B",TRUE
+"1554668_a_at",0.97368753448323,0.873351380159188,0.161258242194694,-5.92702571485752,0.101149323748216,"FAM151A","family with sequence similarity 151 member A",TRUE
+"211166_at",0.934424394408173,0.709290923031148,0.377640662406407,-5.87045991218161,0.175779745609254,"FAM153A","family with sequence similarity 153 member A",TRUE
+"230869_at",0.960278309202107,0.81996827174637,0.230304464726294,-5.91388255016891,0.303994703083334,"FAM155A","family with sequence similarity 155 member A",TRUE
+"214825_at",0.975475861996229,0.883138826626174,-0.148695667538992,-5.92892005388211,-0.15977199795807,"FAM155A","family with sequence similarity 155 member A",TRUE
+"1562696_at",0.774230543658252,0.290156024090362,1.08368648428598,-5.38332404580947,0.797525031472625,"FAM155A-IT1","FAM155A intronic transcript 1",TRUE
+"206299_at",0.902212740485572,0.600798603901952,-0.530857819637188,-5.80334854065871,-0.309669362155491,"FAM155B","family with sequence similarity 155 member B",TRUE
+"223203_at",0.646750698976317,0.11785234959124,-1.6271114854526,-4.72641857254573,-0.447091182634196,"FAM156B///FAM156A","family with sequence similarity 156 member B///family with sequence similarity 156 member A",TRUE
+"1555379_at",0.73759219552868,0.22442768659927,1.24976006183557,-5.20629085853789,0.974258451855738,"FAM159A","family with sequence similarity 159 member A",TRUE
+"237033_at",0.870433264908839,0.50892802170077,-0.671364385168886,-5.72250212307134,-0.261948975578049,"FAM159A","family with sequence similarity 159 member A",TRUE
+"1569465_at",0.782876787164404,0.305252423136551,-1.04951981731202,-5.41697192402704,-0.783064971439594,"FAM160A1","family with sequence similarity 160 member A1",TRUE
+"242687_at",0.837345289209351,0.420235000480652,0.821282352397324,-5.61639097205208,0.275322008701188,"FAM160A1","family with sequence similarity 160 member A1",TRUE
+"223637_s_at",0.950870395622221,0.775528129656442,0.288655753706053,-5.89918162383397,0.104854457404763,"FAM160A2","family with sequence similarity 160 member A2",TRUE
+"1554288_at",0.83949628091616,0.426052515637735,0.810892334222375,-5.62439336427609,0.606954811615542,"FAM160B1","family with sequence similarity 160 member B1",TRUE
+"226155_at",0.97971143730741,0.903269754791573,0.122931330662658,-5.93232560759544,0.0408688913761743,"FAM160B1","family with sequence similarity 160 member B1",TRUE
+"222928_s_at",0.696440263939453,0.166428036291462,1.43084537519197,-4.98886280911979,0.883259171566291,"FAM160B2","family with sequence similarity 160 member B2",TRUE
+"222929_at",0.899798994481376,0.591703210746838,0.544252685921413,-5.79643080740134,0.355872617770172,"FAM160B2","family with sequence similarity 160 member B2",TRUE
+"218337_at",0.91238586368984,0.633073637749213,-0.484088307754699,-5.82618445610942,-0.212350780376461,"FAM160B2","family with sequence similarity 160 member B2",TRUE
+"1557385_at",0.393258278493143,0.0134402849051623,2.68618522114454,-2.92899231440552,1.02252830737158,"FAM161A","family with sequence similarity 161 member A",TRUE
+"242584_at",0.410644531492568,0.0159601212514258,2.60923414837817,-3.07658345872715,1.13206323227192,"FAM161A","family with sequence similarity 161 member A",TRUE
+"1564467_at",0.471502518944839,0.0256642248994941,2.3920526951455,-3.48128891505248,1.08637765743291,"FAM161A","family with sequence similarity 161 member A",TRUE
+"239090_at",0.597654932724127,0.074561067425514,1.8713423701544,-4.36434612991245,1.41242527941088,"FAM161A","family with sequence similarity 161 member A",TRUE
+"235378_at",0.800887499728059,0.336769215076274,-0.981860296584045,-5.48073186953291,-0.454042117092934,"FAM161B","family with sequence similarity 161 member B",TRUE
+"242608_x_at",0.914776697425609,0.641015122577324,-0.472750203074096,-5.83141077213153,-0.126149257506153,"FAM161B","family with sequence similarity 161 member B",TRUE
+"221533_at",0.624988420005843,0.0963138149307709,-1.73676385000325,-4.56849032479744,-0.520949641289495,"FAM162A","family with sequence similarity 162 member A",TRUE
+"235850_at",0.7994347047598,0.334872918318486,-0.985803692931557,-5.47712151407259,-0.481006512411586,"FAM162A","family with sequence similarity 162 member A",TRUE
+"220942_x_at",0.859483694145165,0.476956887109242,-0.723475653246637,-5.68791217691405,-0.227041053944856,"FAM162A","family with sequence similarity 162 member A",TRUE
+"224345_x_at",0.952155285118184,0.781072093147429,-0.281324493397038,-5.9012089620756,-0.0944157884513537,"FAM162A","family with sequence similarity 162 member A",TRUE
+"223193_x_at",0.973493137611142,0.87236675367857,-0.162523486903316,-5.92682643481622,-0.0540312133772378,"FAM162A","family with sequence similarity 162 member A",TRUE
+"228875_at",0.998347572104896,0.992771337119195,0.00916268661304187,-5.93964258953147,0.00576544126916367,"FAM162B","family with sequence similarity 162 member B",TRUE
+"222095_s_at",0.950037803488168,0.773183944066082,0.291760514461775,-5.89830745945478,0.111768879222233,"FAM163A","family with sequence similarity 163 member A",TRUE
+"231267_at",0.966064677476069,0.841907512657518,0.201808884375328,-5.91986639107749,0.0936560926545487,"FAM163A","family with sequence similarity 163 member A",TRUE
+"230816_at",0.862649761550751,0.486290052108668,-0.708060910428598,-5.69840067714532,-0.488215770765473,"FAM163B","family with sequence similarity 163 member B",TRUE
+"233971_at",0.867972140419125,0.501379580009038,-0.68349553955913,-5.71467022281091,-0.407538062573766,"FAM166A","family with sequence similarity 166 member A",TRUE
+"1562778_at",0.870808709484996,0.510218519815462,0.669300556765907,-5.72382117418508,0.420048836646145,"FAM166A","family with sequence similarity 166 member A",TRUE
+"229941_at",0.667209925683767,0.133768441898958,1.5564591141212,-4.82396711079098,1.06662464569581,"FAM166B","family with sequence similarity 166 member B",TRUE
+"233641_s_at",0.683838837468118,0.152758159515366,1.48073542620133,-4.92470758038851,0.9389630091759,"FAM167A","family with sequence similarity 167 member A",TRUE
+"226614_s_at",0.687221961642294,0.155845726610019,1.46916017334078,-4.93975142509446,0.672216687195433,"FAM167A","family with sequence similarity 167 member A",TRUE
+"1552448_a_at",0.806089660856733,0.346509229157376,-0.96184205295555,-5.49885586177082,-0.757048674741811,"FAM167A-AS1","FAM167A antisense RNA 1",TRUE
+"223657_at",0.943302696495236,0.745394598982719,0.32879971626076,-5.88716419207766,0.206958425132604,"FAM167B","family with sequence similarity 167 member B",TRUE
+"36612_at",0.671655467883069,0.137795324796422,-1.53969583569794,-4.8466126367338,-0.65270563935211,"FAM168A","family with sequence similarity 168 member A",TRUE
+"212357_at",0.775805901298839,0.293244851983753,-1.07659402624104,-5.3903881048942,-0.382025357809676,"FAM168A","family with sequence similarity 168 member A",TRUE
+"229946_at",0.709262252160459,0.182047403633518,-1.37771962385915,-5.0551936773408,-0.384002973574846,"FAM168B","family with sequence similarity 168 member B",TRUE
+"212017_at",0.713330901550199,0.187887257025537,-1.358786232815,-5.07833005921866,-0.315133629726738,"FAM168B","family with sequence similarity 168 member B",TRUE
+"213954_at",0.778537373775587,0.298561563674887,1.06451037892292,-5.40232783044903,0.945197883506251,"FAM169A","family with sequence similarity 169 member A",TRUE
+"235048_at",0.803489780415187,0.341661342567402,0.971756918461373,-5.48992177913415,1.13228896689945,"FAM169A","family with sequence similarity 169 member A",TRUE
+"1562319_at",0.439717285988889,0.0202556477801577,2.5011408797072,-3.28030413002195,1.66902325800957,"FAM169B","family with sequence similarity 169 member B",TRUE
+"1562906_at",0.896118635245982,0.578313023624707,-0.564158358564783,-5.78584136325107,-0.207843168802945,"FAM170A","family with sequence similarity 170 member A",TRUE
+"1559828_at",0.940875142749531,0.735195171515943,0.342509843002991,-5.88270561939416,0.2382224901856,"FAM170B","family with sequence similarity 170 member B",TRUE
+"1557660_s_at",0.675622576285316,0.141884311030857,1.52308199489384,-4.86886438943895,0.783160966410206,"FAM170B-AS1","FAM170B antisense RNA 1",TRUE
+"1563255_at",0.877857073443889,0.528814195232641,0.639877042060668,-5.74220285595,0.449300954049463,"FAM170B-AS1","FAM170B antisense RNA 1",TRUE
+"1563254_a_at",0.985709215004606,0.931097494818498,0.0874523963330173,-5.93595914650605,0.082300693016018,"FAM170B-AS1","FAM170B antisense RNA 1",TRUE
+"212771_at",0.457032025390949,0.0226088070083949,2.45071199893933,-3.37381393512309,2.19664257663027,"FAM171A1","family with sequence similarity 171 member A1",TRUE
+"235544_x_at",0.849646596450765,0.451038914850082,0.767238011446436,-5.65696818168379,0.252480303146055,"FAM171A2","family with sequence similarity 171 member A2",TRUE
+"227370_at",0.775351898377291,0.292113894355126,1.07918463736907,-5.38781266805293,0.842248769443426,"FAM171B","family with sequence similarity 171 member B",TRUE
+"238564_at",0.871823968930213,0.514404046414059,0.662626837282274,-5.72805990676834,0.194101448362366,"FAM171B","family with sequence similarity 171 member B",TRUE
+"242762_s_at",0.885029460971826,0.545503019681942,0.613946946583023,-5.75774330263945,0.322528362841801,"FAM171B","family with sequence similarity 171 member B",TRUE
+"212936_at",0.843087230275826,0.437112783456465,-0.791379707374341,-5.63916334865301,-0.339079828926211,"FAM172A","family with sequence similarity 172 member A",TRUE
+"223882_at",0.923050713409153,0.670155417649336,-0.431666176506496,-5.84933151207619,-0.155347481246776,"FAM172A","family with sequence similarity 172 member A",TRUE
+"219709_x_at",0.700061364939874,0.171520106415088,-1.41310382940411,-5.01124409107295,-0.652275265089267,"FAM173A","family with sequence similarity 173 member A",TRUE
+"225670_at",0.819018525257656,0.373813452410577,0.907681540288437,-5.5461737189658,0.226057911604668,"FAM173B","family with sequence similarity 173 member B",TRUE
+"225668_at",0.83633038614858,0.417926693532319,0.825429951583346,-5.61316983427241,0.673216865193069,"FAM173B","family with sequence similarity 173 member B",TRUE
+"226752_at",0.40129202983775,0.0143625265622124,-2.65655717166265,-2.98606028149271,-1.28944039534665,"FAM174A","family with sequence similarity 174 member A",TRUE
+"222085_at",0.80613219453588,0.346566012143195,0.961726482733676,-5.49895950611416,0.698270092309102,"FAM174B","family with sequence similarity 174 member B",TRUE
+"221880_s_at",0.920029531612896,0.659526420131015,0.446560642854016,-5.84301909119687,0.414113599112591,"FAM174B","family with sequence similarity 174 member B",TRUE
+"51158_at",0.984244246588495,0.923301143673121,-0.0973787478662908,-5.9350659010852,-0.0977214045991168,"FAM174B","family with sequence similarity 174 member B",TRUE
+"233543_s_at",0.767011398042819,0.268594296199997,1.13478237899148,-5.33121586341995,0.509386801866047,"FAM175A","family with sequence similarity 175 member A",TRUE
+"226521_s_at",0.895690630367785,0.576313079702158,0.567151122763659,-5.78421736151915,0.206474553957591,"FAM175A","family with sequence similarity 175 member A",TRUE
+"212837_at",0.914910510855952,0.64161610657483,0.47189474708626,-5.83180017905782,0.164745923866803,"FAM175B","family with sequence similarity 175 member B",TRUE
+"212835_at",0.945820394457833,0.75541079076698,0.315398183161809,-5.89134818720571,0.105512716896261,"FAM175B","family with sequence similarity 175 member B",TRUE
+"223812_at",0.895690630367785,0.575317611067016,-0.568642717199774,-5.7834048484199,-0.410260905741224,"FAM178B","family with sequence similarity 178 member B",TRUE
+"236717_at",0.847797601020174,0.44728682534177,-0.773697224916978,-5.65225540453491,-0.38813436507288,"FAM179A","family with sequence similarity 179 member A",TRUE
+"213304_at",0.796838451167002,0.329665949069915,-0.996711492367451,-5.46706640125922,-0.587093661023134,"FAM179B","family with sequence similarity 179 member B",TRUE
+"231117_at",0.812302873476553,0.358987120635242,0.936748232461603,-5.52109244388872,0.311316453650488,"FAM181A","family with sequence similarity 181 member A",TRUE
+"1557211_a_at",0.940227139261806,0.732086518135058,-0.346701733074613,-5.88130645725874,-0.212038010912353,"FAM181A-AS1","FAM181A antisense RNA 1",TRUE
+"231430_at",0.73957587762701,0.228007140137983,1.23983614971958,-5.21748474602169,1.08993890589572,"FAM181B","family with sequence similarity 181 member B",TRUE
+"230994_at",0.870980161749509,0.51107481070545,-0.667932744603275,-5.72469323874419,-0.328567460440926,"FAM181B","family with sequence similarity 181 member B",TRUE
+"231128_at",0.938726197187622,0.726896742009016,0.353714110990569,-5.87892827221656,0.247364997437192,"FAM181B","family with sequence similarity 181 member B",TRUE
+"230539_at",0.766550448794594,0.267718175281915,-1.13692090057095,-5.32898867825503,-0.353149573009159,"FAM182B///FAM182A","family with sequence similarity 182 member B///family with sequence similarity 182 member A",TRUE
+"1569887_a_at",0.859465912277024,0.476647070618322,0.723990351311464,-5.68755825951627,0.257144925685824,"FAM183CP","family with sequence similarity 183 member C, pseudogene",TRUE
+"220150_s_at",0.87106619978761,0.511385261218662,-0.667437156893077,-5.72500878475157,-0.402142722329119,"FAM184A","family with sequence similarity 184 member A",TRUE
+"1558523_at",0.950870395622221,0.775511250700901,0.288678098679384,-5.89917536561273,0.145367852205286,"FAM184A","family with sequence similarity 184 member A",TRUE
+"233823_at",0.884030343410032,0.542674173129783,0.61831201715334,-5.75517056567816,0.440783738106186,"FAM184B","family with sequence similarity 184 member B",TRUE
+"1556373_a_at",0.748136676097718,0.240093319232112,1.20717844019825,-5.25377754819295,0.441875838432447,"FAM185A","family with sequence similarity 185 member A",TRUE
+"236182_at",0.984726013444734,0.925100419689987,0.0950870483586409,-5.93528063599121,0.06147931165399,"FAM185A","family with sequence similarity 185 member A",TRUE
+"216595_at",0.809652358091397,0.35290346223427,-0.948907882195999,-5.51038458503003,-0.415995214944851,"FAM186A","family with sequence similarity 186 member A",TRUE
+"1562317_at",0.944850801239076,0.751961745766559,-0.320006184546266,-5.88992900019012,-0.268273629414513,"FAM186A","family with sequence similarity 186 member A",TRUE
+"224039_at",0.980264692225439,0.907889674400326,-0.117031228350826,-5.93301471490676,-0.0375360467426793,"FAM186B","family with sequence similarity 186 member B",TRUE
+"228300_at",0.580630437263151,0.0631474103648291,1.95633382571228,-4.22989120445833,1.36836614452508,"FAM187A///CCDC103","family with sequence similarity 187 member A///coiled-coil domain containing 103",TRUE
+"242259_at",0.895213601869362,0.573140536371769,0.571909364837135,-5.78161818986391,0.260344138478173,"FAM187B","family with sequence similarity 187 member B",TRUE
+"218297_at",0.870808709484996,0.510334922938988,-0.669114542775316,-5.72393986994344,-0.505157047951236,"FAM188A","family with sequence similarity 188 member A",TRUE
+"1554509_a_at",0.970540753946729,0.859538352972617,-0.179033623043269,-5.92408367555928,-0.10673360211274,"FAM188A","family with sequence similarity 188 member A",TRUE
+"213997_at",0.974292018919448,0.874564772690085,-0.15969940354459,-5.92726910071645,-0.142158136379495,"FAM189A1","family with sequence similarity 189 member A1",TRUE
+"213900_at",0.645636413659377,0.11662462919861,-1.63288624603152,-4.71829722268293,-0.837056222875985,"FAM189A2","family with sequence similarity 189 member A2",TRUE
+"1555515_a_at",0.809930331505913,0.353668145631832,-0.947371748669717,-5.51174430206961,-0.483805049716733,"FAM189B","family with sequence similarity 189 member B",TRUE
+"203550_s_at",0.986342822130003,0.935022827890167,-0.0824581127787505,-5.93637231529473,-0.0293620009813758,"FAM189B","family with sequence similarity 189 member B",TRUE
+"222460_s_at",0.847825099055327,0.447431341189461,-0.773447833691361,-5.65243805778706,-0.237382540767934,"FAM192A","family with sequence similarity 192 member A",TRUE
+"224248_x_at",0.90344422113846,0.60430622689437,-0.525718393562097,-5.80595825426688,-0.146852482287246,"FAM192A","family with sequence similarity 192 member A",TRUE
+"223406_x_at",0.908466056355731,0.619493166610476,-0.503628451893896,-5.81689341565846,-0.146528636361483,"FAM192A","family with sequence similarity 192 member A",TRUE
+"217896_s_at",0.976589025744684,0.888626753563565,-0.141662534377503,-5.92991368901111,-0.0475089049870832,"FAM192A","family with sequence similarity 192 member A",TRUE
+"203600_s_at",0.431769566611896,0.0191844667982812,-2.52593018686121,-3.23397239858329,-0.781842847474223,"FAM193A","family with sequence similarity 193 member A",TRUE
+"243047_at",0.819018525257656,0.373474794436632,0.908336834719978,-5.54561630449807,0.455319521353712,"FAM193B","family with sequence similarity 193 member B",TRUE
+"218920_at",0.903021267024792,0.602974372961322,-0.527668152476633,-5.80497110914689,-0.167036559454608,"FAM193B","family with sequence similarity 193 member B",TRUE
+"244435_at",0.951006866397403,0.776288882462898,-0.287648797154125,-5.89946314627282,-0.216053878194581,"FAM196A","family with sequence similarity 196 member A",TRUE
+"232124_at",0.770807031642694,0.279206748652459,1.10927514136595,-5.35749465525259,0.830099399525627,"FAM198A","family with sequence similarity 198 member A",TRUE
+"223204_at",0.640067422642767,0.110424957572178,-1.66285262782291,-4.6758001335673,-1.58480935221143,"FAM198B","family with sequence similarity 198 member B",TRUE
+"219872_at",0.689168483917391,0.158285365698302,-1.46014482191042,-4.95140206350958,-1.17521640659334,"FAM198B","family with sequence similarity 198 member B",TRUE
+"227133_at",0.517523674854691,0.0366123744734878,-2.22447099052414,-3.78011153556186,-0.754336161507066,"FAM199X","family with sequence similarity 199, X-linked",TRUE
+"225216_at",0.843889133511002,0.439979947688425,-0.786371304255787,-5.64289984833444,-0.180226249694638,"FAM199X","family with sequence similarity 199, X-linked",TRUE
+"242781_at",0.862125670830879,0.48498220413163,-0.71021055153184,-5.69695092151705,-0.275976731391266,"FAM199X","family with sequence similarity 199, X-linked",TRUE
+"230923_at",0.957289701021675,0.806662554108302,-0.247680397187113,-5.90984840262169,-0.198165528561291,"FAM19A1","family with sequence similarity 19 member A1, C-C motif chemokine like",TRUE
+"241399_at",0.864280748950698,0.491593273816468,-0.699378292931854,-5.70421375719736,-0.554588584062513,"FAM19A2","family with sequence similarity 19 member A2, C-C motif chemokine like",TRUE
+"242348_at",0.84525713114706,0.442270068730774,0.782385251884091,-5.6458576573125,0.49059296868687,"FAM19A4","family with sequence similarity 19 member A4, C-C motif chemokine like",TRUE
+"237094_at",0.819018525257656,0.374684026443713,-0.905998801723178,-5.54760340875742,-0.885340738529362,"FAM19A5","family with sequence similarity 19 member A5, C-C motif chemokine like",TRUE
+"229459_at",0.908367146600979,0.619177243396351,0.504085359188764,-5.81667186921613,0.405867014553445,"FAM19A5","family with sequence similarity 19 member A5, C-C motif chemokine like",TRUE
+"229655_at",0.955892698633978,0.800059369472453,-0.256332176872831,-5.9077309967781,-0.182148034246377,"FAM19A5","family with sequence similarity 19 member A5, C-C motif chemokine like",TRUE
+"1566865_at",0.623503825356688,0.0946347596536263,1.74616283984309,-4.55459469799704,1.43066356572112,"FAM200A","family with sequence similarity 200 member A",TRUE
+"238609_at",0.915766032166572,0.644809714224145,-0.467354853962282,-5.83385520181652,-0.208045024007982,"FAM200A","family with sequence similarity 200 member A",TRUE
+"227466_at",0.971216837324271,0.862265593888629,-0.175519560643085,-5.92468960023532,-0.073582897483357,"FAM200B","family with sequence similarity 200 member B",TRUE
+"236321_at",0.981335195954425,0.911652869091287,0.112228402549238,-5.9335506776255,0.0546371372801326,"FAM200B","family with sequence similarity 200 member B",TRUE
+"227270_at",0.998384473324293,0.993345532062868,-0.00843484739279759,-5.93964882789818,-0.00425607756568702,"FAM200B","family with sequence similarity 200 member B",TRUE
+"1557541_at",0.827866702343255,0.397167138787498,0.86340123058864,-5.58297621532419,0.685880547486768,"FAM201A","family with sequence similarity 201 member A",TRUE
+"1557014_a_at",0.986342822130003,0.934758002866974,0.0827949861620036,-5.93634520971648,0.122690746704968,"FAM201A","family with sequence similarity 201 member A",TRUE
+"230667_at",0.610455440146151,0.0831273534570687,-1.81473774222945,-4.45155183846469,-0.625017686823106,"FAM204A","family with sequence similarity 204 member A",TRUE
+"222617_s_at",0.946119745055175,0.75595545378446,0.314671140402014,-5.89157024213096,0.125803189361791,"FAM204A","family with sequence similarity 204 member A",TRUE
+"218390_s_at",0.97112136867183,0.861596984344706,0.17638085608062,-5.92454219613535,0.10913672622069,"FAM204A","family with sequence similarity 204 member A",TRUE
+"234947_s_at",0.991689960875868,0.961200924895528,0.0491997577470158,-5.93850455663556,0.0171821122429225,"FAM204A","family with sequence similarity 204 member A",TRUE
+"243270_at",0.810602600845179,0.354762353630317,0.945177547190124,-5.51368300889665,0.608040871836052,"FAM205A","family with sequence similarity 205 member A",TRUE
+"241690_at",0.943177611554239,0.744661996584911,-0.329782313107074,-5.88685064271452,-0.2251889713167,"FAM205BP","transmembrane protein C9orf144B pseudogene",TRUE
+"216084_at",0.952914447461733,0.784389714274738,-0.276944862561761,-5.90239538123854,-0.163333232748498,"FAM205BP","transmembrane protein C9orf144B pseudogene",TRUE
+"243269_s_at",0.958933497686198,0.814124619985898,0.237926439718017,-5.91214887965446,0.093199921553996,"FAM205BP///FAM205A","transmembrane protein C9orf144B pseudogene///family with sequence similarity 205 member A",TRUE
+"237827_at",0.898647305933017,0.588354938094756,-0.549209060287335,-5.79382864070922,-0.243773976628128,"FAM205C","family with sequence similarity 205 member C",TRUE
+"218998_at",0.970274748961658,0.858768346714509,-0.18002619549389,-5.92391035900071,-0.0680214789146856,"FAM206A","family with sequence similarity 206 member A",TRUE
+"238703_at",0.932830928398943,0.703526837886,0.385522479925704,-5.86755060086889,0.34427743975132,"FAM207A","family with sequence similarity 207 member A",TRUE
+"243750_x_at",0.937755094543801,0.724486262128461,0.356977265654438,-5.87780556170103,0.116485073508128,"FAM207A","family with sequence similarity 207 member A",TRUE
+"209284_s_at",0.638134354959023,0.109512842296854,-1.66738034991399,-4.66932784370899,-0.507755003095752,"FAM208A","family with sequence similarity 208 member A",TRUE
+"227460_at",0.845444642968895,0.442458552493048,-0.782057751161723,-5.6461000461344,-0.389960960981874,"FAM208A","family with sequence similarity 208 member A",TRUE
+"209285_s_at",0.8751553586947,0.522044963736301,0.650520840651293,-5.73564492001882,0.350462011176687,"FAM208A","family with sequence similarity 208 member A",TRUE
+"216211_at",0.665892433917011,0.132994699753145,1.55972770337888,-4.81952903563751,0.582378807983262,"FAM208B","family with sequence similarity 208 member B",TRUE
+"244165_at",0.871708868449496,0.513236109236902,0.664486031652356,-5.72688315152232,0.310460072515327,"FAM208B","family with sequence similarity 208 member B",TRUE
+"1556758_at",0.925511384407886,0.677898483929944,0.420878119161536,-5.85377225698909,0.331096968189925,"FAM208B","family with sequence similarity 208 member B",TRUE
+"238795_at",0.930899509890345,0.694079752682643,0.398494684559302,-5.86263340548015,0.148178661133866,"FAM208B","family with sequence similarity 208 member B",TRUE
+"218331_s_at",0.972438691973544,0.86711516214477,0.169276423053047,-5.9257365561858,0.0600192269293309,"FAM208B","family with sequence similarity 208 member B",TRUE
+"232513_x_at",0.54295328972902,0.0457441635547943,-2.11672696492654,-3.96528845382083,-0.977684101981716,"FAM209B","family with sequence similarity 209 member B",TRUE
+"233086_at",0.774230543658252,0.289119229602531,1.08607929958691,-5.38093147464004,0.692625579603057,"FAM209B///FAM209A","family with sequence similarity 209 member B///family with sequence similarity 209 member A",TRUE
+"226804_at",0.700244954363937,0.172016277678318,-1.41139774749676,-5.01338425222075,-0.770667164328632,"FAM20A","family with sequence similarity 20 member A",TRUE
+"241981_at",0.896229101808264,0.58014385695045,0.561423213223555,-5.78731828232987,0.45835604978503,"FAM20A","family with sequence similarity 20 member A",TRUE
+"243221_at",0.933571898119202,0.705945981816924,0.382211539973242,-5.86877994194521,0.158718120115862,"FAM20A","family with sequence similarity 20 member A",TRUE
+"242945_at",0.954723352940649,0.794179658255028,0.264052873945643,-5.90578047338968,0.138939609989974,"FAM20A","family with sequence similarity 20 member A",TRUE
+"202915_s_at",0.865345395265289,0.494820453828212,0.694120949395482,-5.70770033601996,0.21167950450582,"FAM20B","family with sequence similarity 20 member B",TRUE
+"202916_s_at",0.952697366942815,0.783665960438859,0.277899823814871,-5.90213826232821,0.108638593809028,"FAM20B","family with sequence similarity 20 member B",TRUE
+"229438_at",0.280199223932988,0.00458172650722234,3.15358506581903,-1.99455770581324,2.41918239536017,"FAM20C","family with sequence similarity 20 member C",TRUE
+"226722_at",0.528328646587879,0.0409957178490317,2.17004047821609,-3.87437324913892,3.30001616652934,"FAM20C","family with sequence similarity 20 member C",TRUE
+"234342_at",0.717613212957928,0.1933598767195,1.34146020451421,-5.09926782023145,0.86549270119814,"FAM20C","family with sequence similarity 20 member C",TRUE
+"234466_at",0.802268377942344,0.340041470332618,-0.975091284871618,-5.48689846118759,-0.586726571445813,"FAM20C","family with sequence similarity 20 member C",TRUE
+"230739_at",0.459111781250135,0.0229513999306363,2.4437808011542,-3.38658688720679,1.26865173679901,"FAM210A","family with sequence similarity 210 member A",TRUE
+"242149_at",0.593339168375633,0.070402528735838,1.90089534776877,-4.31806500391317,0.936338783340111,"FAM210A","family with sequence similarity 210 member A",TRUE
+"235022_at",0.596382916302699,0.0728972856224041,1.8829888210973,-4.34616811913553,0.920788260196051,"FAM210A","family with sequence similarity 210 member A",TRUE
+"224693_at",0.627092759817312,0.098947036834823,-1.72230191780885,-4.58976223481074,-0.869486878295863,"FAM210B","family with sequence similarity 210 member B",TRUE
+"224690_at",0.649545816241531,0.120108060396925,-1.61663158506372,-4.74110032699604,-0.877953875778468,"FAM210B","family with sequence similarity 210 member B",TRUE
+"229507_at",0.710883166549249,0.184623217962303,1.36931024281244,-5.06550274860612,0.708126065811664,"FAM212A","family with sequence similarity 212 member A",TRUE
+"236036_at",0.955966019701688,0.801142627186745,0.254911491699706,-5.9080836477942,0.179303942710621,"FAM212B-AS1","FAM212B antisense RNA 1",TRUE
+"224435_at",0.963379172403332,0.83284663875078,-0.21355543189624,-5.91749489766155,-0.101506530369315,"FAM213A","family with sequence similarity 213 member A",TRUE
+"228155_at",0.990810941805126,0.956179385839025,0.0555738583390167,-5.93817932075945,0.0278767677466476,"FAM213A","family with sequence similarity 213 member A",TRUE
+"232662_x_at",0.996145862517277,0.980790432918703,0.0243512323411227,-5.93939466495556,0.00986172677234265,"FAM213A","family with sequence similarity 213 member A",TRUE
+"231835_at",0.812302873476553,0.359407268825542,-0.93591360245646,-5.52182277448015,-0.3588021905441,"FAM213B","family with sequence similarity 213 member B",TRUE
+"225327_at",0.479207620011384,0.0268724382799251,-2.3706253348046,-3.52018883718479,-1.65014649491499,"FAM214A","family with sequence similarity 214 member A",TRUE
+"235193_at",0.86481525165637,0.492503007244025,-0.697894266200545,-5.70520048049399,-0.35019665000295,"FAM214A","family with sequence similarity 214 member A",TRUE
+"211433_x_at",0.773234064853267,0.284527807500978,-1.09675080701179,-5.37020382297342,-0.354997674838042,"FAM214B","family with sequence similarity 214 member B",TRUE
+"207765_s_at",0.79985507957204,0.335313621732744,-0.984885871315206,-5.47796299691657,-0.365391343665124,"FAM214B","family with sequence similarity 214 member B",TRUE
+"221129_at",0.730098225455698,0.21263985628087,1.28332272442225,-5.16786719578396,0.850420742994038,"FAM215A","family with sequence similarity 215 member A (non-protein coding)",TRUE
+"204521_at",0.96287357728432,0.831277610730606,-0.215592603297664,-5.91707002665612,-0.122374618987168,"FAM216A","family with sequence similarity 216 member A",TRUE
+"1556711_at",0.548417444560701,0.0483670583936296,-2.08938170978108,-4.0113621428004,-1.28306385550646,"FAM216B","family with sequence similarity 216 member B",TRUE
+"1560838_at",0.4990824712868,0.0313826344084869,-2.29777969752512,-3.65094423090587,-1.69538439656106,"FAM217A","family with sequence similarity 217 member A",TRUE
+"237619_at",0.958833323462396,0.813802658898445,-0.238346793970818,-5.91205163376937,-0.144874706988617,"FAM217A","family with sequence similarity 217 member A",TRUE
+"225313_at",0.7468442753788,0.238793288341475,-1.21063071040588,-5.24998064515948,-0.478727084169732,"FAM217B","family with sequence similarity 217 member B",TRUE
+"1553711_a_at",0.854040699678541,0.463313691280984,0.746330534867447,-5.67196646434525,0.372931241151615,"FAM218A","family with sequence similarity 218 member A",TRUE
+"1553710_at",0.980434477155705,0.908545774793442,-0.116193672040638,-5.93310979500332,-0.107245305879529,"FAM218A","family with sequence similarity 218 member A",TRUE
+"225146_at",0.864175199827872,0.491445806826667,-0.699619000693916,-5.7040535231576,-0.321400070690677,"FAM219A","family with sequence similarity 219 member A",TRUE
+"224805_s_at",0.522667179791589,0.0385384834166896,-2.19986263696915,-3.82290499360698,-1.26297704334435,"FAM219B","family with sequence similarity 219 member B",TRUE
+"224798_s_at",0.731054546207485,0.214188619582948,-1.27883266347755,-5.17305794662411,-0.465404729180825,"FAM219B","family with sequence similarity 219 member B",TRUE
+"224804_s_at",0.838682969007165,0.423920302359067,-0.814690080149069,-5.62147941787787,-0.284905296317671,"FAM219B","family with sequence similarity 219 member B",TRUE
+"239051_at",0.988224361618126,0.943982270113659,0.071066662360532,-5.93722388213555,0.030632293548388,"FAM21EP///FAM21FP","family with sequence similarity 21, member A pseudogene///family with sequence similarity 21, member F, pseudogene",TRUE
+"224452_s_at",0.792436690618566,0.323687520071187,-1.00938351808837,-5.45525889085549,-0.392100973157877,"FAM220A","family with sequence similarity 220 member A",TRUE
+"228600_x_at",0.789795896476304,0.318414731870372,1.02069580452203,-5.44460425290257,1.32139725864396,"FAM221A","family with sequence similarity 221 member A",TRUE
+"240871_at",0.905166341446495,0.610824811733182,-0.516205060793901,-5.81072371208359,-0.352658195146943,"FAM221B","family with sequence similarity 221 member B",TRUE
+"226487_at",0.164480573939106,0.00132667458815082,-3.67170601863883,-0.905771631140377,-2.38876233974402,"FAM222A","family with sequence similarity 222 member A",TRUE
+"1553811_at",0.701088870826122,0.172816659353554,1.40865391413187,-5.01682173711904,0.782649813393943,"FAM222A-AS1","FAM222A antisense RNA 1",TRUE
+"222641_s_at",0.839425347843955,0.42522057519501,0.812372712247604,-5.62325901417525,0.250045190072045,"FAM222B","family with sequence similarity 222 member B",TRUE
+"218464_s_at",0.91876780831279,0.654676399540208,0.453391041485131,-5.84005405520581,0.145834642468257,"FAM222B","family with sequence similarity 222 member B",TRUE
+"229418_at",0.937113154905832,0.720692857401665,-0.36212056283395,-5.87601530198327,-0.109648676575905,"FAM222B","family with sequence similarity 222 member B",TRUE
+"1552607_at",0.942684843065067,0.743507581533233,-0.33133133538533,-5.88635446522512,-0.176922178260797,"FAM223A///FAM223B","family with sequence similarity 223 member A (non-protein coding)///family with sequence similarity 223 member B (non-protein coding)",TRUE
+"244164_at",0.91671872326659,0.647613951844365,0.46337667880869,-5.83563996636806,0.274065358104644,"FAM223B","family with sequence similarity 223 member B (non-protein coding)",TRUE
+"216786_at",0.711989638658417,0.186100483329994,1.36452914724841,-5.07134046883522,1.27145582415435,"FAM224A","family with sequence similarity 224 member A (non-protein coding)",TRUE
+"235942_at",0.931528703027792,0.697380044055941,0.393955112179745,-5.86437239295998,0.301073981509983,"FAM224A///FAM224B","family with sequence similarity 224 member A (non-protein coding)///family with sequence similarity 224 member B (non-protein coding)",TRUE
+"235941_s_at",0.968870165845344,0.852995597679588,-0.187473498535816,-5.92257949183119,-0.1062016797147,"FAM224A///FAM224B","family with sequence similarity 224 member A (non-protein coding)///family with sequence similarity 224 member B (non-protein coding)",TRUE
+"229059_at",0.596382916302699,0.0729041239715797,-1.88294047941789,-4.34624373575326,-1.78527665083732,"FAM225B///FAM225A","family with sequence similarity 225 member B (non-protein coding)///family with sequence similarity 225 member A (non-protein coding)",TRUE
+"242292_at",0.414637020271776,0.0167538531951906,-2.5873555124485,-3.11816629007913,-1.84057998070659,"FAM226B///FAM226A","family with sequence similarity 226 member B (non-protein coding)///family with sequence similarity 226 member A (non-protein coding)",TRUE
+"1553799_at",0.748184017928985,0.240278579600531,1.20668762319984,-5.25431659866435,0.942168465547816,"FAM227B","family with sequence similarity 227 member B",TRUE
+"1557429_s_at",0.969882914559333,0.856874038010604,-0.182468834199685,-5.9234797735568,-0.146314900571071,"FAM227B","family with sequence similarity 227 member B",TRUE
+"231386_at",0.754754319954017,0.248352381959618,1.18556836020507,-5.27733066106589,0.954264611666767,"FAM228A","family with sequence similarity 228 member A",TRUE
+"230435_at",0.877857073443889,0.528980561217167,0.639616390808922,-5.74236214629409,0.311549287212856,"FAM228B","family with sequence similarity 228 member B",TRUE
+"228451_at",0.975196332002567,0.879283389686222,-0.153641234410302,-5.92819258529116,-0.0551995985044598,"FAM229A","family with sequence similarity 229 member A",TRUE
+"1556560_a_at",0.975794187312778,0.884242613060365,-0.147280488437691,-5.92912384964771,-0.0607980717997054,"FAM229A","family with sequence similarity 229 member A",TRUE
+"225812_at",0.900692252557887,0.59586878479271,0.538105651152483,-5.79962623474166,0.307515901050575,"FAM229B","family with sequence similarity 229 member B",TRUE
+"244243_at",0.774230543658252,0.28836407122272,1.08782601912786,-5.37918196223656,0.338903254204908,"FAM230B","family with sequence similarity 230 member B (non-protein coding)",TRUE
+"237047_at",0.658457617118501,0.126669542146363,1.58705554643115,-4.78213768035532,1.6009846975869,"FAM230C","family with sequence similarity 230 member C",TRUE
+"235186_at",0.988953916818854,0.946651709925424,-0.0676745449376175,-5.93745305374735,-0.033491415154093,"FAM231D///LOC388692","family with sequence similarity 231 member D///uncharacterized LOC388692",TRUE
+"235185_s_at",0.820291269575398,0.378797634437359,0.898082291673894,-5.55429654406049,0.395101443269155,"FAM231D///LOC388692///LINC00869","family with sequence similarity 231 member D///uncharacterized LOC388692///long intergenic non-protein coding RNA 869",TRUE
+"224749_at",0.571677937624457,0.0594984511578873,-1.98637472766993,-4.18138911186456,-0.751779714847904,"FAM234A","family with sequence similarity 234 member A",TRUE
+"213234_at",0.70573152022539,0.177905646784631,-1.39144141787631,-5.03825968372318,-0.617342421709845,"FAM234B","family with sequence similarity 234 member B",TRUE
+"1559302_at",0.932269331146744,0.701494290672266,0.388307702009952,-5.8665083627736,0.160598022856404,"FAM234B","family with sequence similarity 234 member B",TRUE
+"213232_at",0.953553103224247,0.785817106593038,-0.275062251142026,-5.90289969238753,-0.169338104559981,"FAM234B","family with sequence similarity 234 member B",TRUE
+"243143_at",0.912906062613339,0.634734104279061,0.481712371884685,-5.82728967960813,0.315318324731542,"FAM24A","family with sequence similarity 24 member A",TRUE
+"231146_at",0.720507507563255,0.196634240984482,1.33127711937776,-5.11146847129031,0.788764472158991,"FAM24B","family with sequence similarity 24 member B",TRUE
+"1553388_at",0.683019114815084,0.152163609707175,1.48298617736253,-4.92177131419408,1.02113777540301,"FAM26D","family with sequence similarity 26 member D",TRUE
+"232217_at",0.536422380101288,0.0432669625145784,2.14388126694628,-3.91916004351929,1.46100648546595,"FAM26E","family with sequence similarity 26 member E",TRUE
+"230254_at",0.96351240321323,0.833671893210157,0.212484321605509,-5.91771667675864,0.0681446183821031,"FAM26E","family with sequence similarity 26 member E",TRUE
+"228362_s_at",0.62179111032845,0.0921835640305817,1.76014386130598,-4.53382245677745,0.576077691954447,"FAM26F","family with sequence similarity 26 member F",TRUE
+"229391_s_at",0.626253409795776,0.0970850279182258,1.73249365169596,-4.57478507687037,2.57579402195316,"FAM26F","family with sequence similarity 26 member F",TRUE
+"229390_at",0.752913428584105,0.246069963241203,1.19148580602319,-5.27091797471687,1.8248847234211,"FAM26F","family with sequence similarity 26 member F",TRUE
+"229543_at",0.849935057946582,0.451676913229581,0.766142940361517,-5.65776346893771,0.319332326973388,"FAM26F","family with sequence similarity 26 member F",TRUE
+"229915_at",0.975449397348071,0.882773586341352,-0.149164015238937,-5.92885218021719,-0.0946926850794378,"FAM26F","family with sequence similarity 26 member F",TRUE
+"223791_at",0.920780424288498,0.663125018152389,0.441506579998108,-5.8451846081134,0.378909843454164,"FAM27B///FAM27C","family with sequence similarity 27 member B///family with sequence similarity 27 member C",TRUE
+"215487_x_at",0.768852835478002,0.27362250862004,-1.12260692304912,-5.34382553916132,-0.468444924920398,"FAM27B///FAM27C///FAM182B","family with sequence similarity 27 member B///family with sequence similarity 27 member C///family with sequence similarity 182 member B",TRUE
+"222205_x_at",0.974982245454858,0.87823765728076,0.15498332042274,-5.92799107470259,0.0918568834025937,"FAM27B///FAM27C///FAM182B","family with sequence similarity 27 member B///family with sequence similarity 27 member C///family with sequence similarity 182 member B",TRUE
+"216053_x_at",0.726636642789909,0.205954745146468,-1.30299881931435,-5.14493826492093,-0.875073224153644,"FAM27B///FAM27C///FAM182B///FAM182A","family with sequence similarity 27 member B///family with sequence similarity 27 member C///family with sequence similarity 182 member B///family with sequence similarity 182 member A",TRUE
+"1553590_at",0.971216837324271,0.862687385229296,0.174976283630281,-5.92478220791363,0.0848576051030285,"FAM27E2///FAM27E3","family with sequence similarity 27 member E2///family with sequence similarity 27 member E3",TRUE
+"227563_at",0.972819824894874,0.868484862882188,-0.167514383305492,-5.92602520377779,-0.0923491795529845,"FAM27E2///FAM27E3","family with sequence similarity 27 member E2///family with sequence similarity 27 member E3",TRUE
+"220377_at",0.820536502908875,0.380791062325976,0.89426635145325,-5.55750338609133,0.440317299235014,"FAM30A","family with sequence similarity 30, member A",TRUE
+"206478_at",0.883806861047232,0.542095316182755,0.619206717292689,-5.75464106732903,0.232273643868744,"FAM30A","family with sequence similarity 30, member A",TRUE
+"201863_at",0.894978775129642,0.572393558458771,-0.573031635125542,-5.78100208732932,-0.205756533026017,"FAM32A","family with sequence similarity 32 member A",TRUE
+"220547_s_at",0.721317419960934,0.197617597919003,-1.32824487804053,-5.11508638429243,-0.471708031888891,"FAM35A","family with sequence similarity 35 member A",TRUE
+"209405_s_at",0.125040911418878,0.000736409208539161,-3.91368191005116,-0.386705937427838,-1.36798014934433,"FAM3A","family with sequence similarity 3 member A",TRUE
+"38043_at",0.467673691528294,0.0245671944277113,-2.41233134815545,-3.44429576829386,-0.770001803874907,"FAM3A","family with sequence similarity 3 member A",TRUE
+"227194_at",0.841206569659492,0.431207019123556,0.801760140257578,-5.63134801664963,1.36234790128956,"FAM3B","family with sequence similarity 3 member B",TRUE
+"236316_at",0.149201481153625,0.00105590058047604,3.76575598034827,-0.704540637136246,2.60691412644612,"FAM3C","family with sequence similarity 3 member C",TRUE
+"201889_at",0.181652655810598,0.00169822026356736,3.56960706243479,-1.12326310544192,1.64951082978984,"FAM3C","family with sequence similarity 3 member C",TRUE
+"240062_at",0.536422380101288,0.043303311316022,2.14347279703019,-3.91985668006196,0.827756960095684,"FAM3C","family with sequence similarity 3 member C",TRUE
+"227676_at",0.751642481002592,0.244924781738312,1.1944703260356,-5.26767312662716,0.748496048984718,"FAM3D","family with sequence similarity 3 member D",TRUE
+"1561390_at",0.914242258486146,0.639322246623345,0.475161814159251,-5.83030928198623,0.245965739798566,"FAM41AY2///FAM41AY1","family with sequence similarity 41 member A, Y-linked 2///family with sequence similarity 41 member A, Y-linked 1",TRUE
+"1558174_at",0.854688049545347,0.466452080764935,0.741038267630521,-5.67570070355324,0.522641909055092,"FAM43A","family with sequence similarity 43 member A",TRUE
+"227410_at",0.981158705865426,0.911086955736521,0.112950481219273,-5.93347153104558,0.0798857210051427,"FAM43A","family with sequence similarity 43 member A",TRUE
+"1569256_a_at",0.978257169730337,0.89513840881195,-0.133326878735534,-5.93102912605648,-0.120079476048583,"FAM43B","family with sequence similarity 43 member B",TRUE
+"1562919_at",0.72572801299341,0.20478338883333,1.3064972447659,-5.1408305041586,0.805944854078047,"FAM45A","family with sequence similarity 45 member A",TRUE
+"1563920_at",0.80056683899707,0.336407808871851,-0.982610669519566,-5.48004588462148,-0.725128005519606,"FAM45A","family with sequence similarity 45 member A",TRUE
+"225351_at",0.947926063538122,0.76296677875125,-0.305327363051012,-5.89437884543946,-0.103045286988197,"FAM45A///FAM45BP","family with sequence similarity 45 member A///family with sequence similarity 45, member A pseudogene",TRUE
+"222955_s_at",0.952827852442033,0.784128839223423,-0.27728904531578,-5.90230281287801,-0.0919969018532729,"FAM45A///FAM45BP","family with sequence similarity 45 member A///family with sequence similarity 45, member A pseudogene",TRUE
+"221804_s_at",0.969183235742461,0.854033454317989,-0.186133793599477,-5.92282286899885,-0.0620085289365111,"FAM45A///FAM45BP","family with sequence similarity 45 member A///family with sequence similarity 45, member A pseudogene",TRUE
+"224973_at",0.83670902390386,0.418408073572116,-0.824563814271875,-5.61384375512359,-0.623590231934299,"FAM46A","family with sequence similarity 46 member A",TRUE
+"221766_s_at",0.936599157163462,0.717004199148711,-0.367131400588909,-5.87424683130968,-0.276930831240952,"FAM46A","family with sequence similarity 46 member A",TRUE
+"229737_at",0.949038895598021,0.770223236592971,0.295686021791598,-5.89718893189907,0.0784576621182032,"FAM46A","family with sequence similarity 46 member A",TRUE
+"229518_at",0.646392036827936,0.117385949271139,-1.62929929673992,-4.72334434434665,-1.24602456193894,"FAM46B","family with sequence similarity 46 member B",TRUE
+"226811_at",0.544577979658206,0.0466470303619668,-2.1071585406531,-3.98145377699606,-2.54958763693658,"FAM46C","family with sequence similarity 46 member C",TRUE
+"220306_at",0.716219454102037,0.191888589816422,-1.34607992180151,-5.0937070861164,-1.06874464300275,"FAM46C","family with sequence similarity 46 member C",TRUE
+"1552461_at",0.82411378718473,0.391519993088676,-0.873949720355234,-5.57436401115622,-0.534566268897403,"FAM46D","family with sequence similarity 46 member D",TRUE
+"243700_x_at",0.694505490882266,0.163860305024672,1.43995758183283,-4.97727876338509,1.09333564436753,"FAM47A","family with sequence similarity 47 member A",TRUE
+"240426_at",0.910159094731364,0.625939713627284,0.494328578233958,-5.82136014105721,0.31511157982393,"FAM47B","family with sequence similarity 47 member B",TRUE
+"239732_x_at",0.990623482682449,0.952590323300704,0.0601310725527608,-5.93792253767977,0.0352580295635834,"FAM47C","family with sequence similarity 47 member C",TRUE
+"1570398_at",0.588088101610134,0.0669457767612524,1.92664924545085,-4.27732152219288,1.46651663687473,"FAM47E","family with sequence similarity 47 member E",TRUE
+"203986_at",0.869487815945782,0.50677328177258,0.674816897886915,-5.72028683363471,0.440983452710556,"FAM47E-STBD1///FAM47E///STBD1","FAM47E-STBD1 readthrough///family with sequence similarity 47 member E///starch binding domain 1",TRUE
+"208092_s_at",0.615821255316333,0.0867962301083449,1.79203067035392,-4.4859926090245,1.15101062043781,"FAM49A","family with sequence similarity 49 member A",TRUE
+"230276_at",0.650201253901352,0.120407639611362,1.61525217894466,-4.74302733957521,2.15338808328197,"FAM49A","family with sequence similarity 49 member A",TRUE
+"209683_at",0.65284137151906,0.121706040966776,1.60930669003053,-4.75131853972645,2.5975850112234,"FAM49A","family with sequence similarity 49 member A",TRUE
+"217534_at",0.51531387545335,0.0354754919470354,2.23955464779002,-3.75373898651546,1.27510333789554,"FAM49B","family with sequence similarity 49 member B",TRUE
+"217916_s_at",0.610033432202476,0.0823062236625429,1.81993825576295,-4.44361992498721,0.623864785174588,"FAM49B","family with sequence similarity 49 member B",TRUE
+"228987_at",0.831875452294783,0.407073348407062,0.845127913594362,-5.59766476989203,0.560208625911423,"FAM49B","family with sequence similarity 49 member B",TRUE
+"203262_s_at",0.758722841981575,0.255857531282201,-1.16639217717391,-5.29792005886181,-0.423125777066357,"FAM50A","family with sequence similarity 50 member A",TRUE
+"205775_at",0.919695424525124,0.658652848681926,-0.447789312431575,-5.84248898887673,-0.429967922636923,"FAM50B","family with sequence similarity 50 member B",TRUE
+"1569139_s_at",0.160119467990575,0.001259606959224,-3.69310547128727,-0.860053376223584,-1.53376803253006,"FAM53A","family with sequence similarity 53 member A",TRUE
+"236206_at",0.987451785420009,0.940874041394436,0.075017438525684,-5.93694284812227,0.023391333998878,"FAM53A","family with sequence similarity 53 member A",TRUE
+"1554165_at",0.592605015502039,0.0697848268221989,1.90541475852367,-4.31094272760697,1.60425908142954,"FAM53B","family with sequence similarity 53 member B",TRUE
+"203206_at",0.986361618040699,0.93565969893629,-0.0816480143909756,-5.936437045488,-0.0235150096302608,"FAM53B","family with sequence similarity 53 member B",TRUE
+"1559812_at",0.979388236370534,0.900774536114105,0.126119822228908,-5.9319391209033,0.0904047558768042,"FAM53B-AS1","FAM53B antisense RNA 1",TRUE
+"231639_at",0.983212176432519,0.918284577060078,-0.103771104276523,-5.93443993032585,-0.0499953964851212,"FAM53B-AS1","FAM53B antisense RNA 1",TRUE
+"218023_s_at",0.740681080735184,0.230955667815252,-1.23175019222148,-5.22654865468009,-0.332747094983347,"FAM53C","family with sequence similarity 53 member C",TRUE
+"218898_at",0.627565787558134,0.0990905430999428,1.72152324516344,-4.59090381737052,1.12378634641695,"FAM57A","family with sequence similarity 57 member A",TRUE
+"227781_x_at",0.723655063748891,0.200643945643304,1.31898634883667,-5.1260901668595,0.498357996753668,"FAM57B","family with sequence similarity 57 member B",TRUE
+"226466_s_at",0.814200105026391,0.365157764524045,-0.924555335876111,-5.5317021553564,-0.357230771586188,"FAM58A","family with sequence similarity 58 member A",TRUE
+"223038_s_at",0.678772326285111,0.146319932526096,1.50549833276284,-4.89220541183998,0.673987599328351,"FAM60A","family with sequence similarity 60 member A",TRUE
+"220147_s_at",0.788413816943444,0.314504120330231,1.02917061106721,-5.43655183568165,0.419874713215622,"FAM60A","family with sequence similarity 60 member A",TRUE
+"226062_x_at",0.729273475042162,0.211648974653598,-1.28620867032047,-5.16452270922457,-0.424572893513611,"FAM63A","family with sequence similarity 63 member A",TRUE
+"221856_s_at",0.877857073443889,0.528899308338184,-0.639743686888431,-5.74228436034542,-0.380963357377619,"FAM63A","family with sequence similarity 63 member A",TRUE
+"222111_at",0.748184017928985,0.240478466853182,1.20615837419736,-5.25489764476112,0.739021080345699,"FAM63B","family with sequence similarity 63 member B",TRUE
+"37802_r_at",0.757479140651,0.253572530673984,1.17218564524926,-5.29173058335867,0.949555038384498,"FAM63B","family with sequence similarity 63 member B",TRUE
+"214691_x_at",0.775341201891078,0.291782838002878,1.07994432861487,-5.38705637842864,0.5779459330495,"FAM63B","family with sequence similarity 63 member B",TRUE
+"226873_at",0.859502367311367,0.477428826552675,0.722691996199744,-5.68845057675363,0.440319710243115,"FAM63B","family with sequence similarity 63 member B",TRUE
+"221591_s_at",0.68041487556515,0.147990777665248,1.49898778046664,-4.90079267228813,0.68636654301584,"FAM64A","family with sequence similarity 64 member A",TRUE
+"230806_s_at",0.827866702343255,0.397229482633786,0.863285318911308,-5.58307031000603,0.59475573176088,"FAM65A","family with sequence similarity 65 member A",TRUE
+"45749_at",0.84772210282622,0.446957930112013,0.774264982564065,-5.65183937358364,0.38926496998956,"FAM65A","family with sequence similarity 65 member A",TRUE
+"218029_at",0.995375928428862,0.978590622420423,0.0271405267608032,-5.93932471242548,0.0199243623175427,"FAM65A","family with sequence similarity 65 member A",TRUE
+"206707_x_at",0.803583569469174,0.342087641700371,0.97088121720494,-5.49071422341293,0.506400751975923,"FAM65B","family with sequence similarity 65 member B",TRUE
+"209829_at",0.994502206944532,0.97462125747603,0.032174137513169,-5.93917929769006,0.038588645045071,"FAM65B","family with sequence similarity 65 member B",TRUE
+"243978_at",0.638134354959023,0.109411586849163,-1.66788494174676,-4.66860571081942,-1.18248409420097,"FAM65C","family with sequence similarity 65 member C",TRUE
+"227654_at",0.755639383619058,0.249802105398551,-1.18183086604424,-5.28136660384295,-1.21125757555935,"FAM65C","family with sequence similarity 65 member C",TRUE
+"222194_at",0.774230543658252,0.286990102068766,1.0910125533998,-5.3759838785104,0.480637143192154,"FAM66D","family with sequence similarity 66 member D",TRUE
+"213689_x_at",0.9340157600858,0.707531600495265,-0.380043757102162,-5.86957916897345,-0.262014985738404,"FAM69A","family with sequence similarity 69 member A",TRUE
+"216044_x_at",0.971469873887034,0.864221731979725,-0.173000462793563,-5.92511659519883,-0.10699208780199,"FAM69A","family with sequence similarity 69 member A",TRUE
+"1556498_at",0.990539110817582,0.952131375747929,-0.0607139135134885,-5.93788823819953,-0.0523849894837056,"FAM69A","family with sequence similarity 69 member A",TRUE
+"226940_at",0.879389294797525,0.533404943394842,0.632700818056151,-5.74656562736078,0.26614747768512,"FAM69B","family with sequence similarity 69 member B",TRUE
+"229002_at",0.918295771595924,0.653117057718571,-0.455591745341345,-5.83908934372704,-0.448692682958569,"FAM69B","family with sequence similarity 69 member B",TRUE
+"227652_at",0.957073030992577,0.80560839435752,0.24906029025288,-5.90951553556768,0.233265454551231,"FAM69B","family with sequence similarity 69 member B",TRUE
+"229003_x_at",0.966051687342135,0.841572751753976,0.202242342798873,-5.91978125463078,0.101840933279832,"FAM69B","family with sequence similarity 69 member B",TRUE
+"229645_at",0.720952283360079,0.196982007625403,1.33020340649157,-5.112750363538,0.797872277278725,"FAM69C","family with sequence similarity 69 member C",TRUE
+"1564112_at",0.921454318223114,0.665166145983171,0.438645104158329,-5.84639994153262,0.287338171788472,"FAM71A","family with sequence similarity 71 member A",TRUE
+"1552384_a_at",0.924887707997706,0.675084687805624,0.424792512343208,-5.85217372083037,0.310647146782588,"FAM71A","family with sequence similarity 71 member A",TRUE
+"1552383_at",0.986361618040699,0.93560297060379,-0.0817201704095452,-5.9364313058348,-0.0617919135853553,"FAM71A","family with sequence similarity 71 member A",TRUE
+"1555586_at",0.51531387545335,0.0357087071222031,2.23642491035219,-3.75921990198906,0.728839007395885,"FAM71B","family with sequence similarity 71 member B",TRUE
+"1555585_a_at",0.816800680706682,0.368060499132913,0.918867261863668,-5.5366078971335,0.4650413474121,"FAM71B","family with sequence similarity 71 member B",TRUE
+"1553629_a_at",0.871744769522775,0.513455500589763,0.66413661158753,-5.72710455395871,0.200639497656686,"FAM71B","family with sequence similarity 71 member B",TRUE
+"1552526_at",0.841967750949524,0.4343604768117,0.796206529396619,-5.63554119290914,0.327099495903502,"FAM71C","family with sequence similarity 71 member C",TRUE
+"1552839_at",0.847644062908097,0.446609689767982,0.774866411803047,-5.65139835528551,0.522002883817088,"FAM71D","family with sequence similarity 71 member D",TRUE
+"229289_at",0.680532675320266,0.148217340607476,1.49810959235263,-4.90194869695546,1.7252459702556,"FAM71E1","family with sequence similarity 71 member E1",TRUE
+"1552990_at",0.557589172116298,0.0525263911272117,2.0486309466255,-4.07930265020691,1.03466004828298,"FAM71E2","family with sequence similarity 71 member E2",TRUE
+"1564319_at",0.851733415458562,0.456186988144119,-0.758428264618057,-5.66333576675688,-0.406091338743195,"FAM71E2","family with sequence similarity 71 member E2",TRUE
+"236214_at",0.67368843181164,0.140055439831821,1.53046349881874,-4.85900164423079,0.438668891442474,"FAM71F1","family with sequence similarity 71 member F1",TRUE
+"231466_at",0.942477426470706,0.741501764555353,0.334024759691594,-5.88548623910509,0.241054093725637,"FAM71F1","family with sequence similarity 71 member F1",TRUE
+"237320_at",0.5897618614591,0.0679476287775475,1.91906717207065,-4.28935609058061,1.27582381730697,"FAM71F2","family with sequence similarity 71 member F2",TRUE
+"225834_at",0.958325326717984,0.811432313525867,-0.241442887784325,-5.91133011600496,-0.0992468006201577,"FAM72A///FAM72D///FAM72B///FAM72C","family with sequence similarity 72 member A///family with sequence similarity 72 member D///family with sequence similarity 72 member B///family with sequence similarity 72 member C",TRUE
+"216897_s_at",0.776100778010408,0.293619471296667,-1.07573749064162,-5.39123840688699,-0.595006112732727,"FAM76A","family with sequence similarity 76 member A",TRUE
+"228638_at",0.8920930097751,0.5641222000051,0.585508902746686,-5.77407356365051,0.201202035217822,"FAM76A","family with sequence similarity 76 member A",TRUE
+"228604_at",0.951893068371814,0.779601166638228,0.283268075255772,-5.90067653773636,0.0896444101299165,"FAM76A","family with sequence similarity 76 member A",TRUE
+"1553750_a_at",0.637762731416024,0.109087463451352,1.66950282063603,-4.66628920784918,0.707923716005143,"FAM76B","family with sequence similarity 76 member B",TRUE
+"1553749_at",0.831721619185478,0.406467337259003,0.846237555799719,-5.59678116597752,0.409574745735254,"FAM76B","family with sequence similarity 76 member B",TRUE
+"226753_at",0.841813886364358,0.433994643652183,0.796849523666128,-5.63505711182381,0.336113338972751,"FAM76B","family with sequence similarity 76 member B",TRUE
+"232048_at",0.854400503339099,0.465575200453373,0.742514815407061,-5.67466138090573,0.318590353167457,"FAM76B","family with sequence similarity 76 member B",TRUE
+"1558113_at",0.865677601761371,0.495688498918029,0.692710180740283,-5.70863166041344,0.373662114342456,"FAM78B","family with sequence similarity 78 member B",TRUE
+"241456_at",0.93523910610914,0.712064627510037,0.373856590853549,-5.87183561721395,0.258732394329161,"FAM78B","family with sequence similarity 78 member B",TRUE
+"241544_at",0.942324052902057,0.740946315419637,0.334771065340644,-5.88524443685005,0.226727667789411,"FAM78B","family with sequence similarity 78 member B",TRUE
+"241503_at",0.465258652136505,0.0239940760794404,2.42326101816297,-3.42428629596041,1.20892339786715,"FAM81A","family with sequence similarity 81 member A",TRUE
+"227756_at",0.713633547141264,0.188707006916686,1.35616586173463,-5.08151108573699,0.488367567540577,"FAM81A","family with sequence similarity 81 member A",TRUE
+"241481_at",0.935351255251442,0.712584620063629,0.373147802654809,-5.87209177839549,0.12045355425427,"FAM81A","family with sequence similarity 81 member A",TRUE
+"240065_at",0.698391916012681,0.169552000235198,1.41991030270737,-5.00268469566804,0.873782696381893,"FAM81B","family with sequence similarity 81 member B",TRUE
+"238741_at",0.00256170368644906,4.685329101873e-07,7.01371900982733,5.97389022824138,2.92007816196863,"FAM83A","family with sequence similarity 83 member A",TRUE
+"239586_at",0.00655857282011981,2.03924532129926e-06,6.36269173143392,4.73855081365753,2.64077870226795,"FAM83A","family with sequence similarity 83 member A",TRUE
+"242944_at",0.033685940378302,3.51184014917826e-05,5.15915506764288,2.2878142307782,4.10907039292071,"FAM83A","family with sequence similarity 83 member A",TRUE
+"238460_at",0.0550194051692779,9.76193064218977e-05,4.73895062047843,1.39313109245321,5.8615715612803,"FAM83A","family with sequence similarity 83 member A",TRUE
+"1563900_at",0.485183483700012,0.0279795797733176,2.35175677000794,-3.55428048853178,1.56537453564815,"FAM83B","family with sequence similarity 83 member B",TRUE
+"232202_at",0.487765518929235,0.0288916795737908,2.33672181445452,-3.58133489023406,2.34365977861624,"FAM83B","family with sequence similarity 83 member B",TRUE
+"1556793_a_at",0.763356510523603,0.263054133403883,1.14839280130678,-5.31697809691442,0.837196365352875,"FAM83C","family with sequence similarity 83 member C",TRUE
+"1563805_a_at",0.898736771120062,0.588473637616324,-0.54903311467043,-5.79392140695302,-0.356873303484836,"FAM83C","family with sequence similarity 83 member C",TRUE
+"233962_at",0.760463372361683,0.259508589563238,1.15721436252257,-5.3076701899991,0.400290804505986,"FAM83C-AS1","FAM83C antisense RNA 1",TRUE
+"225687_at",0.822173415758858,0.386592686162946,0.883234512364926,-5.56670320033406,0.356470781378196,"FAM83D","family with sequence similarity 83 member D",TRUE
+"220312_at",0.888312537451395,0.554186013825166,-0.600622836848643,-5.76548765258472,-0.59734759426129,"FAM83E","family with sequence similarity 83 member E",TRUE
+"235269_at",0.895758940460776,0.576482625902111,0.566897207016784,-5.7843554704526,0.390698700372244,"FAM83F","family with sequence similarity 83 member F",TRUE
+"228587_at",0.54295328972902,0.0458571637685375,2.11552015493277,-3.9673298650908,1.24192723037302,"FAM83G","family with sequence similarity 83 member G",TRUE
+"226129_at",0.727074488271062,0.207280204461991,1.29905872152933,-5.14955344911689,0.837127307201051,"FAM83H","family with sequence similarity 83 member H",TRUE
+"241406_at",0.996118448346386,0.980614163032389,0.0245747297271227,-5.93938933915926,0.0139571180383919,"FAM83H","family with sequence similarity 83 member H",TRUE
+"234335_s_at",0.655548963436249,0.12407170870852,1.59860897633458,-4.76617715172265,1.52425278622419,"FAM84A","family with sequence similarity 84 member A",TRUE
+"234331_s_at",0.752235383514782,0.245558246455818,1.19281812957263,-5.2694703110459,1.41906033063608,"FAM84A","family with sequence similarity 84 member A",TRUE
+"228319_at",0.811527120049391,0.35572124296486,0.943258450221893,-5.515375264848,0.598549025143421,"FAM84A","family with sequence similarity 84 member A",TRUE
+"225667_s_at",0.830635993561085,0.403727302631255,0.851267950023814,-5.59276191964003,1.13340449728338,"FAM84A","family with sequence similarity 84 member A",TRUE
+"231439_at",0.856340271686102,0.470300768993079,0.734576971956314,-5.68022563999741,0.582354081585008,"FAM84A","family with sequence similarity 84 member A",TRUE
+"228459_at",0.97689149311934,0.889864202609155,-0.140077686784291,-5.93013096232007,-0.134719007928103,"FAM84A","family with sequence similarity 84 member A",TRUE
+"228870_at",0.899808883319249,0.593645663498993,0.541383631164566,-5.79792662565336,0.253226498410564,"FAM84B","family with sequence similarity 84 member B",TRUE
+"230817_at",0.974884920935236,0.876979478326847,-0.156598445507253,-5.92774624976691,-0.045999848083474,"FAM84B","family with sequence similarity 84 member B",TRUE
+"225864_at",0.986342822130003,0.935045823665862,-0.0824288612286547,-5.93637466372804,-0.0445123675926027,"FAM84B","family with sequence similarity 84 member B",TRUE
+"1562903_at",0.868716701790847,0.504975843005335,0.67770322492763,-5.71842649028268,0.624301713961556,"FAM86B3P","family with sequence similarity 86, member A pseudogene",TRUE
+"1562904_s_at",0.881970070870254,0.539243210402189,-0.623622489507339,-5.75201693629013,-0.502428467174179,"FAM86B3P","family with sequence similarity 86, member A pseudogene",TRUE
+"237630_s_at",0.88767000285873,0.55247366162856,-0.603241712329799,-5.7639784378081,-0.267783056843678,"FAM86B3P","family with sequence similarity 86, member A pseudogene",TRUE
+"234049_at",0.970526265934304,0.859341976581152,0.179286743454374,-5.92403956805644,0.152865360361001,"FAM86B3P","family with sequence similarity 86, member A pseudogene",TRUE
+"220353_at",0.915939421175188,0.645222669430451,-0.466768544086406,-5.83411918201034,-0.156404117055325,"FAM86C1","family with sequence similarity 86 member C1",TRUE
+"65585_at",0.793016712530949,0.324863446942459,-1.00687822532148,-5.45760399265567,-0.401480598272858,"FAM86DP///FAM86B2///FAM86FP///FAM86B1///FAM86C1","family with sequence similarity 86, member D, pseudogene///family with sequence similarity 86 member B2///family with sequence similarity 86, member A pseudogene///family with sequence similarity 86 member B1///family with sequence similarity 86 member C1",TRUE
+"1559140_at",0.919695424525124,0.658717768241727,0.447697979650911,-5.84252844302407,0.149061118711194,"FAM87B///FAM87A","family with sequence similarity 87 member B///family with sequence similarity 87 member A",TRUE
+"1559141_s_at",0.991059530537351,0.958187682958214,0.0530243544146645,-5.93831415552082,0.0530504401054475,"FAM87B///FAM87A","family with sequence similarity 87 member B///family with sequence similarity 87 member A",TRUE
+"32209_at",0.575270671804438,0.0607942047233932,-1.97552501255738,-4.19896412244638,-0.745724465801548,"FAM89B","family with sequence similarity 89 member B",TRUE
+"212484_at",0.606900628956089,0.0804281308027611,-1.83200403594851,-4.42515416304085,-0.760916865535895,"FAM89B","family with sequence similarity 89 member B",TRUE
+"203420_at",0.93565329131222,0.713388465165581,-0.372052485356339,-5.87248669068239,-0.131858052068708,"FAM8A1","family with sequence similarity 8 member A1",TRUE
+"220535_at",0.358427723880268,0.0100429712357236,2.8150097632371,-2.67753871162704,1.09001408963045,"FAM90A1","family with sequence similarity 90 member A1",TRUE
+"233643_at",0.981055483128003,0.910668564177602,0.113484368588543,-5.93341268599722,0.0715651711218008,"FAM90A2P///FAM90A25P///FAM86B3P///FAM90A1","family with sequence similarity 90, member A2 pseudogene///family with sequence similarity 90, member A7 pseudogene///family with sequence similarity 86, member A pseudogene///family with sequence similarity 90 member A1",TRUE
+"237045_at",0.255716413540338,0.0037049781707905,3.24354761540373,-1.80863671506761,0.99940439945677,"FAM91A1","family with sequence similarity 91 member A1",TRUE
+"226294_x_at",0.973071267819624,0.869778105851759,-0.16585120021788,-5.92629489377057,-0.064995555107771,"FAM91A1","family with sequence similarity 91 member A1",TRUE
+"235391_at",0.750807729565285,0.243861336916379,1.19725121362626,-5.2646433156779,1.19981316360997,"FAM92A1","family with sequence similarity 92 member A1",TRUE
+"228011_at",0.855405088766616,0.468143611491262,0.738194602570946,-5.67769679401245,0.760336960170647,"FAM92A1","family with sequence similarity 92 member A1",TRUE
+"237910_x_at",0.957430653957785,0.807538939036884,0.246533585200464,-5.91012364542357,0.22637406142233,"FAM92A1","family with sequence similarity 92 member A1",TRUE
+"234016_at",0.780237570670818,0.301690302991875,-1.0574711520069,-5.4092275671291,-1.35792797958743,"FAM95A","family with sequence similarity 95 member A",TRUE
+"224779_s_at",0.493519901382617,0.0299203589131323,-2.32028012753197,-3.61080687352553,-0.615060109216925,"FAM96A","family with sequence similarity 96 member A",TRUE
+"218074_at",0.934867348047609,0.710797936721037,-0.375584001329657,-5.8712093099241,-0.113024838916115,"FAM96B","family with sequence similarity 96 member B",TRUE
+"241832_at",0.696440263939453,0.16638591760155,1.43099392851388,-4.98867444042723,0.529405275955811,"FAM98A","family with sequence similarity 98 member A",TRUE
+"212333_at",0.930527241884777,0.692680031775153,0.400422580772578,-5.8618889447479,0.116016593708554,"FAM98A","family with sequence similarity 98 member A",TRUE
+"1553625_at",0.765116907435848,0.265043595748939,1.14348125710899,-5.3221332697835,1.19659511445507,"FAM98B","family with sequence similarity 98 member B",TRUE
+"1564637_a_at",0.803583569469174,0.341892724651462,0.971281522050219,-5.49035205830034,0.315524097260594,"FAM98B","family with sequence similarity 98 member B",TRUE
+"225086_at",0.856874648266698,0.471393099265993,0.732748831894396,-5.6814990866254,0.270046063394288,"FAM98B","family with sequence similarity 98 member B",TRUE
+"227951_s_at",0.586168493787511,0.0660142613087948,-1.93378907678448,-4.26595895758203,-0.716327292607454,"FAM98C","family with sequence similarity 98 member C",TRUE
+"240441_at",0.320758694666571,0.00710450442142144,2.96568538661421,-2.37719421506378,1.62067400007372,"FAM99B","family with sequence similarity 99 member B (non-protein coding)",TRUE
+"1555133_at",0.913572663544659,0.637478098883409,-0.477792179953203,-5.82910162467898,-0.150765697760828,"FAM9A","family with sequence similarity 9 member A",TRUE
+"1555538_s_at",0.756198431607818,0.251055020398944,1.17861378401968,-5.28483166904622,0.48697615801263,"FAM9B","family with sequence similarity 9 member B",TRUE
+"1553461_at",0.838208800398326,0.422806776519167,-0.816678159005061,-5.61994890706777,-0.561948966429879,"FAM9B","family with sequence similarity 9 member B",TRUE
+"244644_at",0.697172073261335,0.167022475387286,1.42875199290891,-4.99151555905279,2.04431294398565,"FAM9C","family with sequence similarity 9 member C",TRUE
+"232016_at",0.812302873476553,0.360560756478777,0.933625546537578,-5.5238218365647,0.473128294437019,"FAN1","FANCD2/FANCI-associated nuclease 1",TRUE
+"203678_at",0.898609426925686,0.588030020565475,0.549690767899758,-5.79357451561661,0.205236148008995,"FAN1","FANCD2/FANCI-associated nuclease 1",TRUE
+"239289_x_at",0.978197434639598,0.894309298977545,-0.134387683231428,-5.930890922992,-0.0566169593416861,"FAN1","FANCD2/FANCI-associated nuclease 1",TRUE
+"236976_at",0.635174103121116,0.10588307593345,1.68572037566771,-4.6429746470603,0.747108882762381,"FANCA","Fanconi anemia complementation group A",TRUE
+"203805_s_at",0.870343025394166,0.508595512781776,-0.671896624449222,-5.72216132324929,-0.206126130858598,"FANCA","Fanconi anemia complementation group A",TRUE
+"203806_s_at",0.941345931827527,0.737665995145666,-0.339182500884788,-5.88380423352077,-0.139823370072444,"FANCA","Fanconi anemia complementation group A",TRUE
+"215530_at",0.97689149311934,0.890092428216299,-0.139785429901587,-5.93017076258486,-0.053020000448738,"FANCA","Fanconi anemia complementation group A",TRUE
+"243597_at",0.63419617009828,0.105032397260904,1.69009546081739,-4.63665578802512,1.1055318440751,"FANCB","Fanconi anemia complementation group B",TRUE
+"1557217_a_at",0.768852835478002,0.27397806912542,1.12175217532087,-5.34470625245885,0.856343634383287,"FANCB","Fanconi anemia complementation group B",TRUE
+"1553244_at",0.796378050779806,0.328981433925885,0.998154283170518,-5.46572886937419,0.516301736034103,"FANCB","Fanconi anemia complementation group B",TRUE
+"1557218_s_at",0.989524702314661,0.948722593374834,0.0650435890363018,-5.93762308818387,0.051393727993239,"FANCB","Fanconi anemia complementation group B",TRUE
+"242654_at",0.643515428391208,0.11395572251565,1.64561807450291,-4.70031373751035,1.34435626241005,"FANCC","Fanconi anemia complementation group C",TRUE
+"205189_s_at",0.837609393049242,0.421842230358189,0.818402901664347,-5.61861829129102,0.230674653691768,"FANCC","Fanconi anemia complementation group C",TRUE
+"1559513_a_at",0.959131001044522,0.814663389583202,0.237223117003368,-5.91231120643099,0.0929684891056128,"FANCC","Fanconi anemia complementation group C",TRUE
+"242560_at",0.80764044633141,0.349059908876414,-0.956663313495479,-5.50348901771105,-0.370963898852926,"FANCD2","Fanconi anemia complementation group D2",TRUE
+"1568891_x_at",0.901015420810252,0.597265695407883,0.53604896394031,-5.80068748762092,0.50088075168449,"FANCD2","Fanconi anemia complementation group D2",TRUE
+"1568889_at",0.919354071504066,0.656879776612399,-0.450285277548237,-5.841407720842,-0.29040893100145,"FANCD2","Fanconi anemia complementation group D2",TRUE
+"223545_at",0.962377536390494,0.828659811687887,-0.218993545464004,-5.91635178109351,-0.0984548653443227,"FANCD2","Fanconi anemia complementation group D2",TRUE
+"231531_at",0.928176113526188,0.684380280579693,-0.411886273344619,-5.85738918572947,-0.135541210318973,"FANCD2OS","FANCD2 opposite strand",TRUE
+"220255_at",0.784918343662568,0.309661451945768,1.03976859463624,-5.42639757611756,0.344252485195311,"FANCE","Fanconi anemia complementation group E",TRUE
+"218689_at",0.734730148360473,0.219581657377578,-1.26339006026765,-5.19079182631065,-0.665336538661863,"FANCF","Fanconi anemia complementation group F",TRUE
+"222713_s_at",0.862800800218883,0.486495751884344,-0.707723116867874,-5.69862811041822,-0.236121031822904,"FANCF","Fanconi anemia complementation group F",TRUE
+"203564_at",0.893914276642775,0.570010683904616,-0.576616682407883,-5.77902613477249,-0.196003192479115,"FANCG","Fanconi anemia complementation group G",TRUE
+"213008_at",0.899331416659389,0.590060537840039,-0.546682567925312,-5.79515794870811,-0.175334748741655,"FANCI","Fanconi anemia complementation group I",TRUE
+"213007_at",0.957555097864723,0.808426946820953,-0.245371908466358,-5.91040116112803,-0.0814143305762958,"FANCI","Fanconi anemia complementation group I",TRUE
+"223785_at",0.9802233499944,0.907125506038583,-0.118006848850199,-5.93290310175203,-0.0350497647645476,"FANCI","Fanconi anemia complementation group I",TRUE
+"218397_at",0.322131160460075,0.00724280605566536,2.95735330932214,-2.39396376409578,1.07158869524733,"FANCL","Fanconi anemia complementation group L",TRUE
+"1554277_s_at",0.402463840838386,0.0147473701948782,-2.64472074454067,-3.00877519297037,-2.2035125982379,"FANCM","Fanconi anemia complementation group M",TRUE
+"242711_x_at",0.767011398042819,0.268335033320269,-1.13541467895571,-5.33055773330441,-0.3262671465469,"FANCM","Fanconi anemia complementation group M",TRUE
+"234733_s_at",0.840879524142924,0.430346401364632,-0.803280155392663,-5.63019557613175,-0.231963920773208,"FANCM","Fanconi anemia complementation group M",TRUE
+"231971_at",0.921312278448293,0.664697972306673,0.439301111447171,-5.8461220056788,0.294131676188589,"FANCM","Fanconi anemia complementation group M",TRUE
+"232968_at",0.848183177385184,0.447818999205818,0.772779093289612,-5.65292756657439,0.385904830553611,"FANK1","fibronectin type III and ankyrin repeat domains 1",TRUE
+"209955_s_at",0.78065889313777,0.302335293241274,1.05602648295394,-5.41063853080079,0.942072843020934,"FAP","fibroblast activation protein alpha",TRUE
+"1558014_s_at",0.500677386446044,0.0319433673919633,2.28940576749335,-3.66582387429335,0.918335849499702,"FAR1","fatty acyl-CoA reductase 1",TRUE
+"224866_at",0.622917527985155,0.0938228823679598,1.75075885501508,-4.54777967705195,0.638566554156972,"FAR1","fatty acyl-CoA reductase 1",TRUE
+"224865_at",0.705559553212919,0.177331683345988,1.39336295422997,-5.03587723282409,0.731228250027758,"FAR1","fatty acyl-CoA reductase 1",TRUE
+"239108_at",0.779119049888702,0.300221085046786,1.06077017685123,-5.40599902557385,1.45574670562901,"FAR2","fatty acyl-CoA reductase 2",TRUE
+"220615_s_at",0.801262169789791,0.337915008889127,0.979484983719026,-5.48290021430345,1.50615555328035,"FAR2","fatty acyl-CoA reductase 2",TRUE
+"1557796_at",0.977874971442423,0.892906201513383,-0.136183236639327,-5.93065450434834,-0.0714219808671581,"FAR2","fatty acyl-CoA reductase 2",TRUE
+"226809_at",0.87837534922964,0.531362865583363,0.635888827926671,-5.74463332413052,0.761976462782147,"FAR2P3///FAR2P2","fatty acyl-CoA reductase 2 pseudogene 3///fatty acyl-CoA reductase 2 pseudogene 2",TRUE
+"201910_at",0.714590421965913,0.18989011142035,1.35239977960892,-5.08607397188883,0.754236690682246,"FARP1","FERM, ARH/RhoGEF and pleckstrin domain protein 1",TRUE
+"227996_at",0.817815704063733,0.370371491714119,-0.914360051696465,-5.5404753774157,-0.617601698699364,"FARP1","FERM, ARH/RhoGEF and pleckstrin domain protein 1",TRUE
+"237767_at",0.900774308374385,0.596418705078011,-0.537295717541515,-5.80004463313198,-0.351560420743527,"FARP1","FERM, ARH/RhoGEF and pleckstrin domain protein 1",TRUE
+"201911_s_at",0.910114622481711,0.625730033461773,0.494630366871946,-5.82121646826121,0.381280692701354,"FARP1","FERM, ARH/RhoGEF and pleckstrin domain protein 1",TRUE
+"239246_at",0.921603564091029,0.665661570178671,-0.437951126232702,-5.84669352091221,-0.295770548301558,"FARP1","FERM, ARH/RhoGEF and pleckstrin domain protein 1",TRUE
+"225652_at",0.798428326317339,0.332795850998235,-0.990140694269965,-5.47313559273483,-0.278391435140289,"FARP2","FERM, ARH/RhoGEF and pleckstrin domain protein 2",TRUE
+"1554337_at",0.827006487802341,0.395359772806174,0.866766658348537,-5.58023910816348,0.615282409425279,"FARP2","FERM, ARH/RhoGEF and pleckstrin domain protein 2",TRUE
+"1558855_at",0.891343792585597,0.560662174134637,0.590756166565288,-5.77111667310032,0.165821971102308,"FARP2","FERM, ARH/RhoGEF and pleckstrin domain protein 2",TRUE
+"242857_at",0.898364347216388,0.587588613092002,-0.550345388869966,-5.79322882316483,-0.177946955634017,"FARP2","FERM, ARH/RhoGEF and pleckstrin domain protein 2",TRUE
+"204511_at",0.979272554106505,0.898996384239009,-0.128392832228676,-5.93165756989581,-0.0525136296814184,"FARP2","FERM, ARH/RhoGEF and pleckstrin domain protein 2",TRUE
+"204282_s_at",0.817747890324475,0.370203855168018,0.914686369575711,-5.54019596412881,0.253548812307423,"FARS2","phenylalanyl-tRNA synthetase 2, mitochondrial",TRUE
+"204283_at",0.884766357907703,0.544395293251271,0.615654794941688,-5.75673880324228,0.190658984213233,"FARS2","phenylalanyl-tRNA synthetase 2, mitochondrial",TRUE
+"215414_at",0.8920930097751,0.562828155802292,-0.587469421604749,-5.77297177548293,-0.250597100331137,"FARS2","phenylalanyl-tRNA synthetase 2, mitochondrial",TRUE
+"202159_at",0.874834820370747,0.521587085480956,0.651243521865744,-5.73519589028618,0.214484634438987,"FARSA","phenylalanyl-tRNA synthetase alpha subunit",TRUE
+"216602_s_at",0.990810941805126,0.956754139669576,0.0548441789281584,-5.93821855755838,0.0185834089625203,"FARSA","phenylalanyl-tRNA synthetase alpha subunit",TRUE
+"232063_x_at",0.968066640321622,0.849762974181875,0.191648554917931,-5.92180987430146,0.0995545534023883,"FARSB","phenylalanyl-tRNA synthetase beta subunit",TRUE
+"223036_at",0.978255630670068,0.895002409405644,0.133500872387483,-5.93100653288437,0.0745049268172417,"FARSB","phenylalanyl-tRNA synthetase beta subunit",TRUE
+"223035_s_at",0.998347572104896,0.992403464182117,0.00962899839615719,-5.93963832152057,0.00309322186497774,"FARSB","phenylalanyl-tRNA synthetase beta subunit",TRUE
+"216252_x_at",0.558643636945536,0.0527633423170873,2.0463973958267,-4.08300120299246,1.68842609799096,"FAS","Fas cell surface death receptor",TRUE
+"215719_x_at",0.585036027492332,0.0653768926177306,1.93872562555969,-4.25808585159792,1.94422962628281,"FAS","Fas cell surface death receptor",TRUE
+"204780_s_at",0.594303508881191,0.071240058447324,1.89482275334332,-4.32761639834,1.97618942897439,"FAS","Fas cell surface death receptor",TRUE
+"204781_s_at",0.635368778245437,0.106496186187344,1.68258555285817,-4.64749460773202,1.71291993939153,"FAS","Fas cell surface death receptor",TRUE
+"233820_at",0.652992478303356,0.122323467006441,1.60649802103534,-4.75522709098762,0.647251024691273,"FAS","Fas cell surface death receptor",TRUE
+"237522_at",0.957430653957785,0.807299362979463,-0.246847053876028,-5.91004853689179,-0.112956895901756,"FAS-AS1","FAS antisense RNA 1",TRUE
+"210865_at",0.870113177780394,0.508349798588736,-0.672290058724705,-5.72190923590973,-0.369313670279872,"FASLG","Fas ligand",TRUE
+"211333_s_at",0.950031925101785,0.773051618365879,-0.291935860519135,-5.89825781296706,-0.104878080326141,"FASLG","Fas ligand",TRUE
+"212218_s_at",0.0714488726114362,0.000211646019520043,-4.42288056173471,0.712702877819311,-2.30623623651383,"FASN","fatty acid synthase",TRUE
+"217006_x_at",0.748184017928985,0.240666610772263,1.20566052099644,-5.25544402044449,0.75613974021411,"FASN","fatty acid synthase",TRUE
+"202676_x_at",0.194294573776651,0.00202271103790358,-3.4970233115761,-1.27715939207509,-1.01181519644773,"FASTK","Fas activated serine/threonine kinase",TRUE
+"214114_x_at",0.474859593446097,0.0260663441339064,-2.38481969515292,-3.49444176573931,-0.550648656208718,"FASTK","Fas activated serine/threonine kinase",TRUE
+"210975_x_at",0.545412722791443,0.0470943849416332,-2.10247910062016,-3.98934238820644,-0.595767924891078,"FASTK","Fas activated serine/threonine kinase",TRUE
+"219002_at",0.888750194607196,0.55535802776884,0.598832795989812,-5.76651557500472,0.235613745495224,"FASTKD1","FAST kinase domains 1",TRUE
+"216996_s_at",0.595453032706696,0.0721490027763113,-1.88830269800146,-4.33784778370195,-0.533811327305886,"FASTKD2","FAST kinase domains 2",TRUE
+"229135_at",0.70215456577829,0.173628344386328,-1.40588168163154,-5.0202892051563,-1.21383210760571,"FASTKD2","FAST kinase domains 2",TRUE
+"205976_at",0.841813886364358,0.434083173726924,0.796693891083763,-5.6351743142131,0.310880501415954,"FASTKD2","FAST kinase domains 2",TRUE
+"219200_at",0.784607101402888,0.308432746784678,1.0424761354515,-5.42378837156744,0.36897993533375,"FASTKD3","FAST kinase domains 3",TRUE
+"219016_at",0.99176128617116,0.962029069906259,-0.0481487580929736,-5.93855438395994,-0.01686074326477,"FASTKD5","FAST kinase domains 5",TRUE
+"201579_at",0.798428326317339,0.332952278738643,0.989813417866972,-5.47343693125455,0.925090949988164,"FAT1","FAT atypical cadherin 1",TRUE
+"208153_s_at",0.0952827619788257,0.000406607484371302,4.15651548127881,0.137228829465109,2.22618819594264,"FAT2","FAT atypical cadherin 2",TRUE
+"1558964_at",0.819018525257656,0.373954196879942,0.907409318880331,-5.5464051700387,0.714545597253226,"FAT3","FAT atypical cadherin 3",TRUE
+"236029_at",0.83633038614858,0.41778555757884,0.825684013680083,-5.61297202895319,0.634098876013507,"FAT3","FAT atypical cadherin 3",TRUE
+"1560490_at",0.953774206775359,0.786726345703921,0.273863570220035,-5.90321901389157,0.157562572510073,"FAT3","FAT atypical cadherin 3",TRUE
+"219427_at",0.863498371484347,0.488281283057733,0.704794433283632,-5.7005956307681,0.564449397707224,"FAT4","FAT atypical cadherin 4",TRUE
+"231573_at",0.771159692311272,0.280344868459889,1.10658185255693,-5.36023850852717,0.384204598134738,"FATE1","fetal and adult testis expressed 1",TRUE
+"200019_s_at",0.980001024522674,0.904957961856566,-0.120774813394372,-5.93258140370609,-0.0328139198469373,"FAU","FAU, ubiquitin like and ribosomal protein S30 fusion",TRUE
+"230447_at",0.540483367247649,0.0449188107926916,-2.12562378788121,-3.95021596979046,-1.36206205968882,"FAXC","failed axon connections homolog",TRUE
+"232067_at",0.914910510855952,0.641717061306097,0.471751080605454,-5.83186550890705,0.453895714538489,"FAXC","failed axon connections homolog",TRUE
+"48030_i_at",0.947969282616012,0.763485403127533,0.304637319303954,-5.89458293621234,0.111275334108004,"FAXDC2","fatty acid hydroxylase domain containing 2",TRUE
+"220751_s_at",0.955904644595647,0.800791960428247,-0.255371329955564,-5.90796971715651,-0.239309536196148,"FAXDC2","fatty acid hydroxylase domain containing 2",TRUE
+"48031_r_at",0.996261754016157,0.981642137403244,0.0232713507465594,-5.93941971234503,0.0167481455247405,"FAXDC2","fatty acid hydroxylase domain containing 2",TRUE
+"1554468_s_at",0.56861088242915,0.0580990489091554,1.99833014447762,-4.16194799575095,0.742735884721283,"FBF1","Fas binding factor 1",TRUE
+"1556131_s_at",0.622434989367596,0.0925878687360049,-1.75781602177741,-4.53728950683288,-1.29915618632007,"FBF1","Fas binding factor 1",TRUE
+"1555288_s_at",0.931370027472813,0.695945171777661,-0.39592774753502,-5.86361914067802,-0.137300725651295,"FBF1","Fas binding factor 1",TRUE
+"211623_s_at",0.756313947022433,0.251329328738642,1.17791104749274,-5.28558747695448,0.397227816392583,"FBL","fibrillarin",TRUE
+"1555480_a_at",0.245764881224502,0.00335777533195616,3.28502937288266,-1.72238576295458,2.26009851082889,"FBLIM1","filamin binding LIM protein 1",TRUE
+"1554795_a_at",0.398934416346185,0.0140472281768142,2.66647940431549,-2.96698177949246,2.38535711444087,"FBLIM1","filamin binding LIM protein 1",TRUE
+"1555483_x_at",0.411281725160037,0.0163290045930342,2.59894210568368,-3.09616612469452,1.80249575795622,"FBLIM1","filamin binding LIM protein 1",TRUE
+"225258_at",0.468732760220321,0.0247944981042077,2.40806179214306,-3.45209877181399,2.05327938020521,"FBLIM1","filamin binding LIM protein 1",TRUE
+"244071_at",0.94630837494651,0.756977468434578,0.313307371963055,-5.89198539805629,0.114088952590794,"FBLL1","fibrillarin-like 1",TRUE
+"236318_x_at",0.969946179106301,0.857859995987954,0.181197338236859,-5.92370463320307,0.0499455989473514,"FBLL1","fibrillarin-like 1",TRUE
+"207834_at",0.326089462713281,0.00750241490864878,2.94211652823583,-2.42458332788319,1.41740233520503,"FBLN1","fibulin 1",TRUE
+"207835_at",0.580630437263151,0.0631082144782048,1.95664826700795,-4.22938613047353,0.621989503388772,"FBLN1","fibulin 1",TRUE
+"202995_s_at",0.687210721363115,0.155792901532616,1.46935664244063,-4.93949687928768,1.61411793861131,"FBLN1","fibulin 1",TRUE
+"202994_s_at",0.690015152288705,0.159685562904848,1.45502127082616,-4.95799735129454,2.38203909585582,"FBLN1","fibulin 1",TRUE
+"201787_at",0.846898808963473,0.445526062079396,0.776739720905133,-5.65002261779676,0.981106662230165,"FBLN1","fibulin 1",TRUE
+"203886_s_at",0.536422380101288,0.0432464151690838,2.14411230493878,-3.91876597631109,2.70221056056108,"FBLN2","fibulin 2",TRUE
+"203088_at",0.94895689004559,0.769472296223545,-0.296682421699889,-5.89690266051393,-0.242066762619785,"FBLN5","fibulin 5",TRUE
+"229247_at",0.594005743610726,0.0708012784845789,-1.89799632408169,-4.32262745073493,-1.52714506898216,"FBLN7","fibulin 7",TRUE
+"202766_s_at",0.523369751179323,0.038815300732364,2.19641822467064,-3.82887156641804,2.78243238836205,"FBN1","fibrillin 1",TRUE
+"202765_s_at",0.633963464516753,0.104843121100329,1.69107300267823,-4.63524225255338,1.85131083185994,"FBN1","fibrillin 1",TRUE
+"235318_at",0.640067422642767,0.110438402320946,1.66278612483933,-4.675895098476,1.09111009292115,"FBN1","fibrillin 1",TRUE
+"1554737_at",0.512957854428756,0.0343840466035907,-2.2544558081238,-3.72758056027821,-1.26614687140859,"FBN2","fibrillin 2",TRUE
+"215717_s_at",0.633098477100746,0.104399890190516,1.69336799848428,-4.63192124418821,1.37650399126894,"FBN2","fibrillin 2",TRUE
+"203184_at",0.728385463227073,0.209086699554934,1.29372001751813,-5.15578795216749,1.09271403600733,"FBN2","fibrillin 2",TRUE
+"240117_at",0.767232419466657,0.269276585856055,1.13312052324001,-5.33294406536346,0.645216056967247,"FBN3","fibrillin 3",TRUE
+"209696_at",0.823074246722209,0.389482164287159,-0.877780442776553,-5.571212415543,-1.25417270951419,"FBP1","fructose-bisphosphatase 1",TRUE
+"206844_at",0.843753336849204,0.439432482891374,0.787326071947686,-5.64218927092289,0.305215240398574,"FBP2","fructose-bisphosphatase 2",TRUE
+"242217_s_at",0.608709711882903,0.0813175060043939,-1.82626014507964,-4.43395568066015,-0.817354134859411,"FBRS","fibrosin",TRUE
+"238771_at",0.893864194031613,0.569428135717281,-0.577494289498193,-5.77854061008625,-0.45394890835608,"FBRS","fibrosin",TRUE
+"218255_s_at",0.902923711181172,0.602576687216801,-0.528250743246841,-5.80467545847294,-0.147778808850266,"FBRS","fibrosin",TRUE
+"228522_at",0.327864702134751,0.0077106378615797,-2.93025616148176,-2.44837538438361,-1.15425083392363,"FBRSL1","fibrosin like 1",TRUE
+"239676_x_at",0.721499527275875,0.197762863996776,1.32779794228414,-5.11561905772856,0.345703143246073,"FBRSL1","fibrosin like 1",TRUE
+"242415_at",0.92887101967341,0.68677215146395,0.408576904961918,-5.85870102062952,0.163404169406965,"FBRSL1","fibrosin like 1",TRUE
+"225704_at",0.983498417373669,0.919463625846217,0.102268314052468,-5.93459066452967,0.0525573606161949,"FBRSL1","fibrosin like 1",TRUE
+"225703_at",0.988765741729843,0.945914948415417,-0.0686106813938759,-5.9373909273743,-0.0315049591367824,"FBRSL1","fibrosin like 1",TRUE
+"1557539_at",0.99192897657015,0.96281062252543,-0.0471569398847322,-5.93860041901455,-0.0155257646459317,"FBRSL1","fibrosin like 1",TRUE
+"220127_s_at",0.801285128907773,0.337966352173737,0.979378674978915,-5.48299714818168,0.323717179791547,"FBXL12","F-box and leucine rich repeat protein 12",TRUE
+"237256_at",0.912686134671598,0.633580287909657,0.483363050852122,-5.82652239049855,0.183040371676259,"FBXL12","F-box and leucine rich repeat protein 12",TRUE
+"1553798_a_at",0.68865058167867,0.157906097851865,1.46153893361449,-4.94960423773716,1.01829251845054,"FBXL13","F-box and leucine rich repeat protein 13",TRUE
+"1556770_a_at",0.974536463688956,0.875581170470312,-0.158393954846961,-5.92747110958376,-0.148155879529356,"FBXL13","F-box and leucine rich repeat protein 13",TRUE
+"1553682_at",0.774230543658252,0.288975006557594,-1.08641264071461,-5.38059779406343,-0.785829392375817,"FBXL14","F-box and leucine rich repeat protein 14",TRUE
+"1553683_s_at",0.864837421576847,0.492814229560276,0.697386937345646,-5.70553734275372,0.304066469788367,"FBXL14","F-box and leucine rich repeat protein 14",TRUE
+"213145_at",0.947969282616012,0.763446372063043,-0.304689245932664,-5.89456759405776,-0.115881886748763,"FBXL14","F-box and leucine rich repeat protein 14",TRUE
+"218938_at",0.676475496596199,0.143492736997507,-1.5166544997651,-4.87742150415989,-0.649288904172927,"FBXL15","F-box and leucine rich repeat protein 15",TRUE
+"227641_at",0.69114521567028,0.160831103410571,-1.45085648674177,-4.96334458246853,-1.59710956073397,"FBXL16","F-box and leucine rich repeat protein 16",TRUE
+"232409_x_at",0.720021194788968,0.196119302067813,-1.33286970175324,-5.10956550546878,-1.08637788140444,"FBXL16","F-box and leucine rich repeat protein 16",TRUE
+"244360_at",0.40221114169538,0.0145708083234328,-2.65011460532028,-2.99842999872447,-1.40307495914153,"FBXL17","F-box and leucine rich repeat protein 17",TRUE
+"238174_at",0.620223198657182,0.0900185129137027,-1.7727606918414,-4.51497250795952,-0.747533054144144,"FBXL17","F-box and leucine rich repeat protein 17",TRUE
+"227203_at",0.73957587762701,0.227763346882805,-1.24050827479841,-5.21672903192902,-0.467688736699975,"FBXL17","F-box and leucine rich repeat protein 17",TRUE
+"242034_at",0.919177722942441,0.655879199740542,-0.451695078510578,-5.8407943814347,-0.133173035377694,"FBXL17","F-box and leucine rich repeat protein 17",TRUE
+"233087_at",0.934081042629428,0.708438676350629,0.378804479922295,-5.87003405676876,0.243862538088479,"FBXL17","F-box and leucine rich repeat protein 17",TRUE
+"216395_at",0.831875452294783,0.406847605392552,0.845541139189221,-5.59733584632639,0.543330128170759,"FBXL18","F-box and leucine rich repeat protein 18",TRUE
+"227500_at",0.88767000285873,0.552362657531809,0.603411628983098,-5.76388029862756,0.219612667429123,"FBXL18","F-box and leucine rich repeat protein 18",TRUE
+"220896_at",0.909769794095567,0.624700272148694,-0.49611315940734,-5.82050930983457,-0.337521581743984,"FBXL18","F-box and leucine rich repeat protein 18",TRUE
+"1553361_x_at",0.961212424803935,0.823599612052236,0.22557509276406,-5.91493004609141,0.0679649343102007,"FBXL18","F-box and leucine rich repeat protein 18",TRUE
+"1553359_at",0.984161165881616,0.92269170580384,0.0981550964075682,-5.93499199777494,0.0286167967700113,"FBXL18","F-box and leucine rich repeat protein 18",TRUE
+"215068_s_at",0.993952584307899,0.971701135506932,0.0358777241313735,-5.93905654713453,0.0160798452323014,"FBXL18","F-box and leucine rich repeat protein 18",TRUE
+"228277_at",0.821187434813103,0.3825899867763,-0.890833982222159,-5.56037708595528,-0.369796376751104,"FBXL19","F-box and leucine rich repeat protein 19",TRUE
+"1553586_at",0.927934056345262,0.683735770299872,0.412778810506575,-5.85703360106564,0.195865006418067,"FBXL19-AS1","FBXL19 antisense RNA 1 (head to head)",TRUE
+"214436_at",0.639375236152764,0.109936288890208,1.66527442544766,-4.67233988668262,1.25157619410275,"FBXL2","F-box and leucine rich repeat protein 2",TRUE
+"239223_s_at",0.803794790259171,0.342364390956663,-0.970313119780855,-5.49122796048614,-0.591334411378379,"FBXL20","F-box and leucine rich repeat protein 20",TRUE
+"235089_at",0.819203514175924,0.375878847377068,-0.903693524325517,-5.54955804265465,-0.534051018174889,"FBXL20","F-box and leucine rich repeat protein 20",TRUE
+"232412_at",0.848324203347824,0.448157225230884,-0.7721959141131,-5.65335411949272,-0.51492189620959,"FBXL20","F-box and leucine rich repeat protein 20",TRUE
+"226842_at",0.919407940282366,0.657665117523687,-0.449179390526235,-5.84188752540593,-0.222723905272847,"FBXL20","F-box and leucine rich repeat protein 20",TRUE
+"239224_at",0.92186037171741,0.666812992647057,-0.436339085323228,-5.84737371509936,-0.41354055104661,"FBXL20","F-box and leucine rich repeat protein 20",TRUE
+"1555412_at",0.465776708318531,0.0241158244112561,2.42091914452403,-3.42857784041697,1.99354620532323,"FBXL21","F-box and leucine rich repeat protein 21 (gene/pseudogene)",TRUE
+"1555413_s_at",0.635174103121116,0.105909110634519,-1.68558694837981,-4.64316715942478,-1.1454018339352,"FBXL21","F-box and leucine rich repeat protein 21 (gene/pseudogene)",TRUE
+"1553500_at",0.812302873476553,0.358221643031683,0.938270552802157,-5.51975882039625,0.667088431091445,"FBXL21","F-box and leucine rich repeat protein 21 (gene/pseudogene)",TRUE
+"241350_at",0.586662909412305,0.0661719279807166,-1.93257439354042,-4.26789408968471,-0.926359456107332,"FBXL22","F-box and leucine rich repeat protein 22",TRUE
+"235608_at",0.665892433917011,0.132995800244605,1.55972304331731,-4.81953536826654,1.09855027771162,"FBXL3","F-box and leucine rich repeat protein 3",TRUE
+"225132_at",0.794181673615973,0.325937678541725,1.00459510014497,-5.45973653216057,0.271185890630484,"FBXL3","F-box and leucine rich repeat protein 3",TRUE
+"209943_at",0.562414216355319,0.0549920851864064,2.02581579331715,-4.11695724354352,0.592765303223363,"FBXL4","F-box and leucine rich repeat protein 4",TRUE
+"235450_at",0.645740804644555,0.116778720816556,1.63215866286721,-4.7193216801214,0.657997390354242,"FBXL4","F-box and leucine rich repeat protein 4",TRUE
+"236994_at",0.755940660414394,0.25054517761683,1.17992144709985,-5.28342420193058,0.444434778013248,"FBXL4","F-box and leucine rich repeat protein 4",TRUE
+"209004_s_at",0.906476756086155,0.614037790724337,-0.511533730271606,-5.81303264720012,-0.179241993560428,"FBXL5","F-box and leucine rich repeat protein 5",TRUE
+"209005_at",0.950887541143339,0.77569711660516,-0.288432050926074,-5.89924425042998,-0.102181483699959,"FBXL5","F-box and leucine rich repeat protein 5",TRUE
+"239416_at",0.773754791548713,0.285368493885414,-1.09478761065917,-5.37218435811267,-0.602136213239561,"FBXL6","F-box and leucine rich repeat protein 6",TRUE
+"219189_at",0.872897186254214,0.51724047627369,0.658121369450087,-5.73089847873568,0.319707012346369,"FBXL6","F-box and leucine rich repeat protein 6",TRUE
+"213249_at",0.592111379991983,0.0692019823461964,-1.90971142015575,-4.30416056996721,-0.995400806656553,"FBXL7","F-box and leucine rich repeat protein 7",TRUE
+"220080_at",0.893864194031613,0.569428356167063,-0.577493957304668,-5.77854079400326,-0.458925165328976,"FBXL8","F-box and leucine rich repeat protein 8",TRUE
+"1558062_at",0.774230543658252,0.288630285392013,1.08720987665284,-5.37979937600148,0.453895205227996,"FBXO10","F-box protein 10",TRUE
+"237036_at",0.801455134542848,0.338147948335103,-0.979002760323138,-5.48333983582799,-0.619751233170414,"FBXO10","F-box protein 10",TRUE
+"236100_at",0.868039927215454,0.50177350761209,0.682859918281412,-5.71508391081298,0.297302362249623,"FBXO10","F-box protein 10",TRUE
+"227222_at",0.93758426939333,0.723196310345269,-0.358725142087748,-5.87720000456546,-0.294434248649934,"FBXO10","F-box protein 10",TRUE
+"203255_at",0.41571890355396,0.0169024805230993,2.58336707929463,-3.12572810601366,0.694086679925398,"FBXO11","F-box protein 11",TRUE
+"222119_s_at",0.793672728437026,0.325496320888076,1.00553250847901,-5.45886148249634,0.256976814341161,"FBXO11","F-box protein 11",TRUE
+"219208_at",0.872010957446544,0.514735073113921,0.662100315502576,-5.72839258836983,0.327520761957472,"FBXO11","F-box protein 11",TRUE
+"231472_at",0.632154505039772,0.102971523034005,-1.70082061670915,-4.62111344330735,-1.0967461158502,"FBXO15","F-box protein 15",TRUE
+"228427_at",0.685360765794715,0.153975627479333,1.47614866349048,-4.93068020132684,0.617759869139813,"FBXO16","F-box protein 16",TRUE
+"232693_s_at",0.895690630367785,0.576219200469777,0.567291734365558,-5.78414085477264,0.534122483822444,"FBXO16///ZNF395","F-box protein 16///zinc finger protein 395",TRUE
+"223216_x_at",0.951810226174863,0.778744653672939,0.284400326073403,-5.90036469249652,0.151093792247641,"FBXO16///ZNF395","F-box protein 16///zinc finger protein 395",TRUE
+"221123_x_at",0.986145735582101,0.932090798936962,0.0861883844184962,-5.93606601024982,0.0426446725727558,"FBXO16///ZNF395","F-box protein 16///zinc finger protein 395",TRUE
+"220233_at",0.896139457361073,0.578532129027927,0.56383080065825,-5.78601860431628,0.696692970821593,"FBXO17","F-box protein 17",TRUE
+"224683_at",0.914488991533795,0.639832573850821,0.474434519649025,-5.8306420473486,0.142594831549488,"FBXO18","F-box protein, helicase, 18",TRUE
+"1559561_at",0.946913677125713,0.75889703979333,0.310747546452096,-5.89275983234195,0.138917028120661,"FBXO18","F-box protein, helicase, 18",TRUE
+"219305_x_at",0.594303508881191,0.0712442182209006,1.8947927488961,-4.32766353837147,1.58861984389689,"FBXO2","F-box protein 2",TRUE
+"228036_s_at",0.867587472747223,0.500352413180895,0.685154254239304,-5.71358893174222,0.234630762022577,"FBXO2","F-box protein 2",TRUE
+"212229_s_at",0.763650705722297,0.263571910127845,-1.1471118959875,-5.31832441345818,-0.526307995402913,"FBXO21","F-box protein 21",TRUE
+"212231_at",0.766550448794594,0.26739325411497,-1.13771530649652,-5.32816039408376,-0.47709194254522,"FBXO21","F-box protein 21",TRUE
+"214891_at",0.919378883093968,0.657379769614457,-0.449581140658222,-5.84171335430364,-0.314499851692137,"FBXO21","F-box protein 21",TRUE
+"225734_at",0.734730148360473,0.219635151249871,-1.26323835091384,-5.19096513159113,-0.504222894502856,"FBXO22","F-box protein 22",TRUE
+"1559214_at",0.757950630724418,0.254344920446998,1.17022297546939,-5.29383041623821,0.616370664697814,"FBXO22","F-box protein 22",TRUE
+"225737_s_at",0.91425934480731,0.63958858124435,-0.474782214089624,-5.83048302592162,-0.194714617571876,"FBXO22","F-box protein 22",TRUE
+"225736_at",0.92887602386045,0.686867080835446,-0.408445657604965,-5.85875283245811,-0.163951445346527,"FBXO22","F-box protein 22",TRUE
+"219638_at",0.963120895816356,0.832450007747481,0.214070316154057,-5.91738789300232,0.101368343609628,"FBXO22","F-box protein 22",TRUE
+"223941_at",0.225324722896169,0.00278178670242183,-3.36404926013716,-1.55724936771737,-1.90959589227844,"FBXO24","F-box protein 24",TRUE
+"221157_s_at",0.921006039723366,0.663773544597037,-0.440596999948116,-5.84557176815482,-0.210942473049183,"FBXO24","F-box protein 24",TRUE
+"225591_at",0.989165631647297,0.94724708078261,0.0669181061523835,-5.93750263135869,0.0294546058591756,"FBXO25","F-box protein 25",TRUE
+"235169_at",0.54295328972902,0.0461157977226885,2.11276805790791,-3.97198247297389,1.40125971011688,"FBXO27","F-box protein 27",TRUE
+"1555970_at",0.540483367247649,0.044990815977463,2.1248417780192,-3.95154241422424,1.12863128610685,"FBXO28","F-box protein 28",TRUE
+"1555972_s_at",0.853460212676856,0.461797291848781,0.748895287169159,-5.67014770929467,0.267063069086042,"FBXO28","F-box protein 28",TRUE
+"1555971_s_at",0.859064198633089,0.47558038376285,-0.725763937985094,-5.68633687089419,-0.226757488177778,"FBXO28","F-box protein 28",TRUE
+"202272_s_at",0.904637638851685,0.60858494069031,-0.519468484690156,-5.80909853725125,-0.150493978527543,"FBXO28","F-box protein 28",TRUE
+"202271_at",0.957908678321985,0.810565066347812,0.242576268735182,-5.91106367612122,0.0919779937947087,"FBXO28","F-box protein 28",TRUE
+"238686_at",0.700061364939874,0.171577524332755,1.41290619643126,-5.01149211681299,0.644379940266239,"FBXO3","F-box protein 3",TRUE
+"229955_at",0.758081075834994,0.254876164339374,1.16887563705964,-5.29527013186758,0.464893392330531,"FBXO3","F-box protein 3",TRUE
+"242791_at",0.77461303044884,0.291002316331398,1.0817378838803,-5.38526896909476,0.502999431984326,"FBXO3","F-box protein 3",TRUE
+"232851_at",0.82064687791745,0.381469178170929,0.892971252114661,-5.55858889039769,0.661225575983547,"FBXO3","F-box protein 3",TRUE
+"218432_at",0.854184492233394,0.464207171249196,0.744821694405023,-5.67303367343091,0.319529446332325,"FBXO3","F-box protein 3",TRUE
+"232815_at",0.88113080359582,0.537719422701489,-0.625986817008423,-5.75060452117144,-0.29162911543007,"FBXO3","F-box protein 3",TRUE
+"242007_at",0.69866353626144,0.169996897093306,1.41836616434739,-5.00462947059007,1.05331598315369,"FBXO30","F-box protein 30",TRUE
+"226541_at",0.724067243569133,0.201406865534178,1.3166695571706,-5.12883352308542,0.430810002215038,"FBXO30","F-box protein 30",TRUE
+"224162_s_at",0.721868021715132,0.198018629858658,-1.32701165862254,-5.1165558113754,-0.462125569288894,"FBXO31","F-box protein 31",TRUE
+"222352_at",0.755685495730197,0.249903540831615,1.18156996507722,-5.28164792316946,0.472426843103277,"FBXO31","F-box protein 31",TRUE
+"241762_at",0.642592458809121,0.112882762799507,1.65080731019526,-4.69295334509152,1.58714087868675,"FBXO32","F-box protein 32",TRUE
+"225801_at",0.74371414757151,0.234519901568914,1.22207971556909,-5.23732150397976,1.18770721968059,"FBXO32","F-box protein 32",TRUE
+"225345_s_at",0.840575764979183,0.42973330447387,0.804364152046759,-5.62937246217402,0.561255744215689,"FBXO32","F-box protein 32",TRUE
+"232729_at",0.842928408549809,0.436874129673855,0.791797500559988,-5.63885064657653,0.530054339702396,"FBXO32","F-box protein 32",TRUE
+"225803_at",0.88113080359582,0.537122734959686,0.626913624243524,-5.75004945587246,0.548108030407361,"FBXO32","F-box protein 32",TRUE
+"225328_at",0.902770867950228,0.602282684964165,0.528681561609482,-5.80445662436325,0.44135166678665,"FBXO32","F-box protein 32",TRUE
+"241763_s_at",0.943464796017993,0.74694103199166,0.326726658151084,-5.88782267304583,0.302145121980191,"FBXO32","F-box protein 32",TRUE
+"226970_at",0.761748280722165,0.261101413748143,-1.15324035670401,-5.31187103499969,-0.405074421609358,"FBXO33","F-box protein 33",TRUE
+"227521_at",0.874623344533688,0.521123559674899,-0.651975472209276,-5.73474061351185,-0.216796410194734,"FBXO33","F-box protein 33",TRUE
+"218539_at",0.858711967211834,0.474533578003445,-0.727506737002732,-5.68513391802019,-0.177234961608532,"FBXO34","F-box protein 34",TRUE
+"236525_at",0.789927874973432,0.319120748100835,-1.01917355872533,-5.44604425548326,-0.685876959687787,"FBXO36","F-box protein 36",TRUE
+"1555195_at",0.975196332002567,0.8792378924213,-0.153699619267951,-5.92818385534215,-0.111244538064396,"FBXO36","F-box protein 36",TRUE
+"221257_x_at",0.95168059103032,0.778354026845408,-0.28491683368284,-5.90022202567598,-0.154739114843379,"FBXO38","F-box protein 38",TRUE
+"224369_s_at",0.977858230085336,0.892563507102206,-0.136621854461854,-5.93059627597083,-0.0700115219504607,"FBXO38","F-box protein 38",TRUE
+"219608_s_at",0.996261754016157,0.981761962626452,0.02311942588128,-5.93942314503434,0.0152532890028914,"FBXO38","F-box protein 38",TRUE
+"1552830_at",0.867852903118377,0.501042718693173,0.684039305890714,-5.71431602573413,0.345943494809454,"FBXO39","F-box protein 39",TRUE
+"220550_at",0.83149082353763,0.406187259366558,0.846750751536946,-5.5963721443121,0.626475953339694,"FBXO4","F-box protein 4",TRUE
+"233366_at",0.877865895397814,0.529400901747723,0.638958027549398,-5.74276421036252,0.416713459100223,"FBXO4","F-box protein 4",TRUE
+"223493_at",0.944646698916914,0.751046616088377,-0.321230001687839,-5.88954865958321,-0.140608649491258,"FBXO4","F-box protein 4",TRUE
+"222954_at",0.650100641070116,0.120369876737836,1.6154258990427,-4.74278472484913,0.579029977477204,"FBXO40","F-box protein 40",TRUE
+"220164_s_at",0.877861946695164,0.529362891103861,0.639017550472489,-5.74272787593281,0.357600817116261,"FBXO40","F-box protein 40",TRUE
+"47773_at",0.61760967235709,0.0877786877317561,-1.78609095002469,-4.49494965142387,-0.501154029651178,"FBXO42","F-box protein 42",TRUE
+"221812_at",0.708894565317004,0.181373676153034,-1.37993471595428,-5.0524694669089,-0.668824331676291,"FBXO42","F-box protein 42",TRUE
+"221813_at",0.788384937488466,0.314474386862112,-1.02923532993178,-5.43649011120352,-0.301234676780748,"FBXO42","F-box protein 42",TRUE
+"1559566_at",0.974138689437749,0.874223152418118,0.160138240070699,-5.92720082243846,0.083077649689197,"FBXO42","F-box protein 42",TRUE
+"236852_at",0.710396184548121,0.183384211224731,1.37334361103642,-5.06056478728755,1.11583372160242,"FBXO43","F-box protein 43",TRUE
+"222861_x_at",0.850984014275628,0.454081935165165,0.762023299062524,-5.66074571240469,0.246620836102601,"FBXO44","F-box protein 44",TRUE
+"223517_at",0.979998976135556,0.904681999496843,-0.121127287583951,-5.93253990389835,-0.0349516441555116,"FBXO44","F-box protein 44",TRUE
+"225100_at",0.830635993561085,0.40420216808163,0.850394590897017,-5.59346132037122,0.369661305144437,"FBXO45","F-box protein 45",TRUE
+"225099_at",0.95168059103032,0.778193091940917,0.285129653406553,-5.90016316709321,0.126946840736935,"FBXO45","F-box protein 45",TRUE
+"242294_at",0.983498417373669,0.919400013820205,-0.102349386383842,-5.93458258879462,-0.0478201142167212,"FBXO45","F-box protein 45",TRUE
+"205310_at",0.659642261650716,0.127495895716972,-1.58342182045636,-4.787138833407,-0.458378714268008,"FBXO46","F-box protein 46",TRUE
+"234863_x_at",0.868397087637799,0.503952157765978,0.679349644488388,-5.71736191077893,0.233205773823999,"FBXO5","F-box protein 5",TRUE
+"218875_s_at",0.887780176248324,0.553000405722993,0.602435656361364,-5.76444362998158,0.183584751207077,"FBXO5","F-box protein 5",TRUE
+"231769_at",0.801086839730802,0.337077961576542,-0.981219697128013,-5.48131712276159,-0.561411887299455,"FBXO6","F-box protein 6",TRUE
+"243649_at",0.907964244160782,0.617816217071714,0.506055003385178,-5.81571457901305,0.188813567757742,"FBXO7","F-box protein 7",TRUE
+"1554423_a_at",0.975687277225595,0.884052084385112,0.147524745683999,-5.92908881374613,0.0464019675192429,"FBXO7","F-box protein 7",TRUE
+"201178_at",0.97928472590149,0.899289449823642,0.12801815938959,-5.93170432512201,0.0409989063905556,"FBXO7","F-box protein 7",TRUE
+"223240_at",0.782471668844017,0.304801713716098,-1.05052223457608,-5.41599849203963,-0.423260183228878,"FBXO8","F-box protein 8",TRUE
+"1554806_a_at",0.831957210365167,0.408096952924329,-0.843256022085683,-5.5991528978088,-0.314261030812002,"FBXO8","F-box protein 8",TRUE
+"1566509_s_at",0.488346123638981,0.0290272839974665,-2.33452390892715,-3.5852815787655,-0.748333317012923,"FBXO9","F-box protein 9",TRUE
+"210638_s_at",0.539684095760623,0.0445368932797792,-2.12979056864886,-3.94314306767955,-0.769533536695743,"FBXO9","F-box protein 9",TRUE
+"212987_at",0.603702127972549,0.0781675871045014,-1.84685553018901,-4.40230520919085,-0.70315446454059,"FBXO9","F-box protein 9",TRUE
+"1566511_at",0.747780646916362,0.239685726642784,1.20825929510406,-5.25258980515449,1.19192652202691,"FBXO9","F-box protein 9",TRUE
+"1559094_at",0.821745015752602,0.384568928958777,-0.887070327481952,-5.563516385338,-0.462275500694865,"FBXO9","F-box protein 9",TRUE
+"1559096_x_at",0.884749233889577,0.544270511294737,-0.615847294371185,-5.75662541280504,-0.279024364383614,"FBXO9","F-box protein 9",TRUE
+"238472_at",0.914746370982129,0.640860942904607,-0.472969724045942,-5.83131073403492,-0.207633030548633,"FBXO9","F-box protein 9",TRUE
+"1566507_a_at",0.975265330414469,0.880535675883894,-0.15203443848207,-5.92843154138516,-0.0870739232355966,"FBXO9","F-box protein 9",TRUE
+"212991_at",0.987952662687141,0.94236127374562,-0.0731269134659272,-5.93707922411876,-0.0271869037738943,"FBXO9","F-box protein 9",TRUE
+"209455_at",0.690381347688918,0.160133022039909,-1.45339160255085,-4.96009119202488,-0.365811855198618,"FBXW11","F-box and WD repeat domain containing 11",TRUE
+"209456_s_at",0.861320275790658,0.481587914682159,-0.715805288267883,-5.69315811663272,-0.280515383050686,"FBXW11","F-box and WD repeat domain containing 11",TRUE
+"1564138_at",0.85069818933195,0.453678814675949,-0.76271289742304,-5.66024756533218,-0.38400099608897,"FBXW12","F-box and WD repeat domain containing 12",TRUE
+"215600_x_at",0.995111934465262,0.977021456342409,0.0291303163094507,-5.93927017944526,0.00918477102329085,"FBXW12","F-box and WD repeat domain containing 12",TRUE
+"1560752_at",0.68033297785336,0.147631726504217,1.50038176141812,-4.89895655515765,0.586110300530176,"FBXW2","F-box and WD repeat domain containing 2",TRUE
+"209630_s_at",0.724970327905974,0.202586515812473,-1.31310068951487,-5.13305151592553,-0.492894196432525,"FBXW2","F-box and WD repeat domain containing 2",TRUE
+"218941_at",0.836802432816621,0.418842128059333,-0.823783366302513,-5.61445043573139,-0.280966833178068,"FBXW2","F-box and WD repeat domain containing 2",TRUE
+"235195_at",0.879948283821082,0.534835187805045,-0.630471904193009,-5.74791105727802,-0.246908602254807,"FBXW2","F-box and WD repeat domain containing 2",TRUE
+"241736_at",0.983783029912313,0.920952480068019,0.100370996668993,-5.93477783359939,0.0480244373321614,"FBXW2","F-box and WD repeat domain containing 2",TRUE
+"221519_at",0.321614980455327,0.0071584411236574,-2.96241759616809,-2.38377326977211,-0.974667695996285,"FBXW4","F-box and WD repeat domain containing 4",TRUE
+"214623_at",0.812302873476553,0.359561911056942,0.935606568575701,-5.52209128946379,0.753034872345532,"FBXW4P1","F-box and WD repeat domain containing 4 pseudogene 1",TRUE
+"223050_s_at",0.605913415325856,0.0793807200718741,-1.83883969362181,-4.41465391039788,-0.58595394466438,"FBXW5","F-box and WD repeat domain containing 5",TRUE
+"229419_at",0.525020012390103,0.0391552309258179,-2.1922188700883,-3.83613812592341,-1.16149998015481,"FBXW7","F-box and WD repeat domain containing 7",TRUE
+"222729_at",0.63349344745453,0.104695871809769,-1.69183452701375,-4.63414065359503,-0.718642008510948,"FBXW7","F-box and WD repeat domain containing 7",TRUE
+"218751_s_at",0.642592458809121,0.113078789546396,-1.64985616035947,-4.69430377906394,-0.885950264417448,"FBXW7","F-box and WD repeat domain containing 7",TRUE
+"239494_at",0.89967769475675,0.591110561903019,0.545128963749606,-5.7959724170763,0.377238791567741,"FBXW7","F-box and WD repeat domain containing 7",TRUE
+"231883_at",0.95915232180739,0.814880374947876,-0.236939893691776,-5.91237643934094,-0.227984954296578,"FBXW8","F-box and WD repeat domain containing 8",TRUE
+"223419_at",0.95442332217412,0.790428597273631,0.268986974752683,-5.90450383424131,0.0844207712794756,"FBXW9","F-box and WD repeat domain containing 9",TRUE
+"231496_at",0.986342822130003,0.934386078580257,-0.0832681128449472,-5.93630695442271,-0.063221146509802,"FCAMR","Fc fragment of IgA and IgM receptor",TRUE
+"211305_x_at",0.647518308302168,0.118727045136248,1.62302792090511,-4.73214812268002,1.2252132683553,"FCAR","Fc fragment of IgA receptor",TRUE
+"211816_x_at",0.76711764189372,0.268963930654645,1.13388167484752,-5.33215280374372,0.777951754164476,"FCAR","Fc fragment of IgA receptor",TRUE
+"211306_s_at",0.828607509614823,0.39898104623805,-0.860033534403535,-5.58570524964509,-0.402422859783989,"FCAR","Fc fragment of IgA receptor",TRUE
+"211307_s_at",0.960799624802067,0.821815368148029,0.227898185689673,-5.91441821277942,0.107503340643665,"FCAR","Fc fragment of IgA receptor",TRUE
+"207674_at",0.996555192440456,0.982848571412286,0.0217417535323789,-5.93945324675652,0.0198930366076251,"FCAR","Fc fragment of IgA receptor",TRUE
+"1562537_at",0.760244814241272,0.258525781817304,1.15967542444616,-5.30506228851722,0.690663422564064,"FCER1A","Fc fragment of IgE receptor Ia",TRUE
+"211734_s_at",0.954672574687803,0.793516022254963,0.264925321762966,-5.90555644641046,0.129794872071908,"FCER1A","Fc fragment of IgE receptor Ia",TRUE
+"1554899_s_at",0.695744345349551,0.165414640932719,1.43442805134637,-4.98431544258673,0.803599261024877,"FCER1G","Fc fragment of IgE receptor Ig",TRUE
+"204232_at",0.983567332578112,0.919918814601292,-0.101688204996308,-5.93464826351708,-0.0371389793252082,"FCER1G","Fc fragment of IgE receptor Ig",TRUE
+"206760_s_at",0.896907177224677,0.581952938371337,0.558724808413596,-5.78876853893093,0.207562256713662,"FCER2","Fc fragment of IgE receptor II",TRUE
+"206759_at",0.999503346640971,0.998628015570153,0.0017390333954777,-5.9396820077548,0.000921144492690651,"FCER2","Fc fragment of IgE receptor II",TRUE
+"240928_at",0.67368843181164,0.140289704733241,1.52951357594014,-4.86027300267129,0.603197216730329,"FCF1","FCF1 rRNA-processing protein",TRUE
+"215567_at",0.91005849310518,0.625648503669305,0.49474772371093,-5.82116057495585,0.20770426474823,"FCF1","FCF1 rRNA-processing protein",TRUE
+"219927_at",0.976392182310915,0.887576150179283,-0.143008373221069,-5.92972726687006,-0.0722218467282918,"FCF1","FCF1 rRNA-processing protein",TRUE
+"203240_at",0.889389445320988,0.557073773031345,0.596215855626542,-5.76801300661198,0.445490576384637,"FCGBP","Fc fragment of IgG binding protein",TRUE
+"216951_at",0.835487689403823,0.414711633073528,0.831230931346984,-5.60863916324928,0.795836400598279,"FCGR1A","Fc fragment of IgG receptor Ia",TRUE
+"214511_x_at",0.541615053063084,0.0451915477288302,2.12266767438726,-3.95522849991015,1.55526370056045,"FCGR1B","Fc fragment of IgG receptor Ib",TRUE
+"216950_s_at",0.871451481476429,0.512826869542884,0.665138041526177,-5.72646972125154,0.299166264011596,"FCGR1CP///FCGR1B///FCGR1A","Fc fragment of IgG receptor Ic, pseudogene///Fc fragment of IgG receptor Ib///Fc fragment of IgG receptor Ia",TRUE
+"203561_at",0.747479171009186,0.23924801998465,1.20942154988962,-5.25131158362865,0.936266667583505,"FCGR2A","Fc fragment of IgG receptor IIa",TRUE
+"1565673_at",0.95018792835023,0.773660601240193,-0.291128968820686,-5.89848602653442,-0.279215601089287,"FCGR2A","Fc fragment of IgG receptor IIa",TRUE
+"210889_s_at",0.943631120237335,0.747906119495392,0.325433658312164,-5.88823129092527,0.280518522044219,"FCGR2B","Fc fragment of IgG receptor IIb",TRUE
+"210992_x_at",0.548924465506383,0.0485623710956447,2.08739914361309,-4.01468757912763,0.957407778316684,"FCGR2C","Fc fragment of IgG receptor IIc (gene/pseudogene)",TRUE
+"211396_at",0.73957587762701,0.227934087718697,-1.24003749392235,-5.21725839858153,-0.603489581442817,"FCGR2C","Fc fragment of IgG receptor IIc (gene/pseudogene)",TRUE
+"211395_x_at",0.768170884271101,0.271315005873968,1.12817385539011,-5.3380749828975,0.511457950033465,"FCGR2C","Fc fragment of IgG receptor IIc (gene/pseudogene)",TRUE
+"1565674_at",0.729789891627758,0.212092087076467,-1.28491681728616,-5.16602061215196,-1.02607800661042,"FCGR2C///FCGR2A","Fc fragment of IgG receptor IIc (gene/pseudogene)///Fc fragment of IgG receptor IIa",TRUE
+"204007_at",0.850206060456713,0.452768148367642,0.764272090977817,-5.65911967625207,0.250755409299167,"FCGR3B","Fc fragment of IgG receptor IIIb",TRUE
+"204006_s_at",0.871451481476429,0.512477652628298,-0.665694650951786,-5.72611647567637,-0.435097766203218,"FCGR3B///FCGR3A","Fc fragment of IgG receptor IIIb///Fc fragment of IgG receptor IIIa",TRUE
+"218831_s_at",0.968066640321622,0.849991705608647,0.191353025837325,-5.92186490676936,0.231186464706482,"FCGRT","Fc fragment of IgG receptor and transporter",TRUE
+"213669_at",0.94895689004559,0.769366402869638,0.296822953014146,-5.89686220822642,0.325067742865421,"FCHO1","FCH domain only 1",TRUE
+"1555153_s_at",0.927395026557689,0.682053535409666,0.415110029735627,-5.85610127774029,0.168618226663383,"FCHO2","FCH domain only 2",TRUE
+"228220_at",0.967869536976107,0.848680408627499,-0.193047505281548,-5.92154821785602,-0.0655150173815215,"FCHO2","FCH domain only 2",TRUE
+"226698_at",0.362885168249175,0.0105132163970131,2.7949070890507,-2.7171183213929,2.37562322674598,"FCHSD1","FCH and double SH3 domains 1",TRUE
+"226699_at",0.973515224681688,0.872545973564865,0.162293169250005,-5.9268628262322,0.119370370578234,"FCHSD1","FCH and double SH3 domains 1",TRUE
+"203620_s_at",0.637907046898546,0.109205486218023,1.66891323421692,-4.6671335840355,0.642982410898142,"FCHSD2","FCH and double SH3 domains 2",TRUE
+"1554360_at",0.853297110808539,0.460003030582128,0.751936500767802,-5.66798342118844,0.353046071182934,"FCHSD2","FCH and double SH3 domains 2",TRUE
+"221601_s_at",0.931456860024139,0.696969942395017,0.3945187495028,-5.8641575458194,0.501167083300049,"FCMR","Fc fragment of IgM receptor",TRUE
+"221602_s_at",0.99739139970986,0.986686678374386,0.016875881938605,-5.93954476836633,0.0191339453608927,"FCMR","Fc fragment of IgM receptor",TRUE
+"1560034_a_at",0.689848451630875,0.158676645969574,1.45870938483353,-4.95325172700085,1.11202490114913,"FCN1","ficolin 1",TRUE
+"205237_at",0.694819513561858,0.164372979996254,1.43812909917946,-4.97960807090606,0.661682810255779,"FCN1","ficolin 1",TRUE
+"207804_s_at",0.50578136089344,0.0330619585520468,2.27309527836889,-3.69471440681964,1.4155206403747,"FCN2","ficolin 2",TRUE
+"1559577_at",0.970526265934304,0.859376884707145,0.179241747561097,-5.92404741335692,0.133043719667358,"FCN2","ficolin 2",TRUE
+"208439_s_at",0.974982245454858,0.877925830313127,-0.155383573379984,-5.92793063930906,-0.0879394075615894,"FCN2","ficolin 2",TRUE
+"205866_at",0.978072252406502,0.893876338631225,0.134941696997544,-5.93081831071027,0.0754445188261625,"FCN3","ficolin 3",TRUE
+"243968_x_at",0.422574093216884,0.0176394147770147,2.56406422821286,-3.16224279619669,1.87422458833103,"FCRL1","Fc receptor like 1",TRUE
+"235982_at",0.902642697632346,0.60192689082168,-0.529203062658494,-5.80419149568095,-0.397762243451561,"FCRL1","Fc receptor like 1",TRUE
+"224194_at",0.75536453281804,0.249296853218308,1.18313159938835,-5.27996326505123,0.933172788733505,"FCRL2","Fc receptor like 2",TRUE
+"221239_s_at",0.77340139236553,0.28478987489475,1.09613836995158,-5.37082200787878,0.815028729187556,"FCRL2","Fc receptor like 2",TRUE
+"1563674_at",0.87579870142401,0.523749248110853,0.647833979017628,-5.73731017290228,0.422057043628874,"FCRL2","Fc receptor like 2",TRUE
+"224192_at",0.93601609274026,0.714143140761541,0.371024588094271,-5.87285625301301,0.230892218293588,"FCRL2","Fc receptor like 2",TRUE
+"224193_s_at",0.963737076458538,0.834363010529142,-0.211587505586937,-5.91790151329115,-0.148378388981008,"FCRL2","Fc receptor like 2",TRUE
+"231093_at",0.697172073261335,0.167122373474941,1.42840077839392,-4.99196030924159,0.875732254009645,"FCRL3","Fc receptor like 3",TRUE
+"1553196_a_at",0.883190352125328,0.541092404666522,-0.620758056847512,-5.75372121031712,-0.182460789159634,"FCRL3","Fc receptor like 3",TRUE
+"224402_s_at",0.588115749894983,0.066970437290282,-1.92646141914441,-4.27762004371994,-1.53041698062383,"FCRL4","Fc receptor like 4",TRUE
+"224403_at",0.862388151566272,0.485343243449945,-0.70961679537126,-5.69735177950561,-0.740892801334222,"FCRL4","Fc receptor like 4",TRUE
+"224401_s_at",0.896115372949367,0.577405869802222,-0.565515198620657,-5.78510611616158,-0.484100362996943,"FCRL4","Fc receptor like 4",TRUE
+"224404_s_at",0.296090407530139,0.00530994460411698,3.0907380599977,-2.12344445313793,1.71322469572704,"FCRL5","Fc receptor like 5",TRUE
+"224405_at",0.632949074657601,0.103763754226773,-1.69667632589083,-4.6271279096073,-0.994763248596793,"FCRL5","Fc receptor like 5",TRUE
+"224406_s_at",0.677013732819214,0.143803653488045,1.51541885358742,-4.87906324865257,0.867875712646548,"FCRL5","Fc receptor like 5",TRUE
+"1555799_at",0.811999821706863,0.356151215808913,0.942399046011283,-5.51613206297011,0.645289437447201,"FCRL5","Fc receptor like 5",TRUE
+"231647_s_at",0.961212424803935,0.823180072926632,-0.226121219817076,-5.914810190327,-0.269567690364283,"FCRL5","Fc receptor like 5",TRUE
+"235401_s_at",0.432151440378733,0.0193541391533469,2.52191887574,-3.24148564678822,2.28576981761412,"FCRLA","Fc receptor like A",TRUE
+"235372_at",0.758189649141895,0.255082177716353,1.16835370853176,-5.29582745505721,0.632369342955057,"FCRLA","Fc receptor like A",TRUE
+"235400_at",0.886148073306164,0.548933682575336,0.608669310800793,-5.76083042325138,0.373052027441175,"FCRLA","Fc receptor like A",TRUE
+"238452_at",0.896159990898752,0.579179774089983,0.562862949226393,-5.78654172392328,0.562570912634265,"FCRLB","Fc receptor like B",TRUE
+"229152_at",0.988765741729843,0.945876400464378,-0.0686596625236218,-5.93738765327251,-0.108174252327897,"FDCSP","follicular dendritic cell secreted protein",TRUE
+"210950_s_at",0.841813886364358,0.433886867179237,-0.797039017173912,-5.63491438068882,-0.300258025765201,"FDFT1","farnesyl-diphosphate farnesyltransferase 1",TRUE
+"241954_at",0.920749013376768,0.662879561497251,0.441850939876992,-5.84503782787554,0.196090857777828,"FDFT1","farnesyl-diphosphate farnesyltransferase 1",TRUE
+"208647_at",0.93789466363241,0.725309192980363,-0.355862791769983,-5.87819014923775,-0.124628832775375,"FDFT1","farnesyl-diphosphate farnesyltransferase 1",TRUE
+"201275_at",0.754965837630846,0.24849041692005,-1.18521179468609,-5.27771617895114,-0.394456785647176,"FDPS","farnesyl diphosphate synthase",TRUE
+"231366_at",0.586576404049536,0.0661514422929938,1.93273207367373,-4.26764293413828,0.838103285476584,"FDPSP2","farnesyl diphosphate synthase pseudogene 2",TRUE
+"203647_s_at",0.701308253942732,0.173037049811689,1.40790016474409,-5.01776507284378,0.515959163659726,"FDX1","ferredoxin 1",TRUE
+"203646_at",0.70573152022539,0.178101303501874,1.39078751819286,-5.0390698124267,0.60465376644142,"FDX1","ferredoxin 1",TRUE
+"239161_at",0.756584150514497,0.251908492718389,1.1764291930494,-5.28717995157125,0.465378128470491,"FDX1","ferredoxin 1",TRUE
+"226451_at",0.89623945563082,0.58021640493395,0.561314920509539,-5.78737661476141,0.246688206120153,"FDX1L","ferredoxin 1 like",TRUE
+"229989_at",0.94943075115007,0.771567015094,0.293903764724725,-5.8976986027016,0.170725548331363,"FDXACB1","ferredoxin-fold anticodon binding domain containing 1",TRUE
+"207813_s_at",0.995032257518762,0.97683901665653,-0.0293616676063148,-5.93926358868306,-0.0192544320126053,"FDXR","ferredoxin reductase",TRUE
+"203115_at",0.554642754132296,0.0510394399303688,-2.06285633754217,-4.05568476863318,-1.2790410085142,"FECH","ferrochelatase",TRUE
+"203116_s_at",0.597654932724127,0.0741689950788701,-1.87406627424076,-4.36010172589944,-0.731795688180137,"FECH","ferrochelatase",TRUE
+"229696_at",0.933298127911264,0.704801580957215,-0.383777269614533,-5.86819989456987,-0.136905005740338,"FECH","ferrochelatase",TRUE
+"223175_s_at",0.432648367402428,0.0194424698437634,-2.5198435765706,-3.24537029774657,-0.771400130483816,"FEM1A","fem-1 homolog A",TRUE
+"228435_at",0.682440016647909,0.149872707193583,-1.49172619552603,-4.91033528970249,-0.535126770618219,"FEM1A","fem-1 homolog A",TRUE
+"230853_at",0.765934384067577,0.266257142363067,-1.14049859735176,-5.32525438353469,-0.918949305676887,"FEM1A","fem-1 homolog A",TRUE
+"212367_at",0.48580305784244,0.0285489246025088,-2.34231984080412,-3.57127316429829,-0.83147458102786,"FEM1B","fem-1 homolog B",TRUE
+"212373_at",0.729083413548563,0.210827603481378,-1.28860883811635,-5.16173631600503,-0.421910861908223,"FEM1B","fem-1 homolog B",TRUE
+"212374_at",0.989669132517581,0.95047089344157,-0.0628228264587336,-5.93776136784211,-0.0209614198188932,"FEM1B","fem-1 homolog B",TRUE
+"213341_at",0.85463333818278,0.466355163563961,-0.741201382056402,-5.67558598582813,-0.329389339684347,"FEM1C","fem-1 homolog C",TRUE
+"204767_s_at",0.803583569469174,0.341925164107465,-0.971214889701487,-5.49041235158903,-0.324121017292686,"FEN1","flap structure-specific endonuclease 1",TRUE
+"204768_s_at",0.883276865022197,0.541187640864004,-0.620610676169905,-5.75380869409619,-0.248796185091035,"FEN1","flap structure-specific endonuclease 1",TRUE
+"242332_at",0.843816788557882,0.439669696552467,0.786912286510046,-5.64249732678305,0.316528255253869,"FENDRR","FOXF1 adjacent non-coding developmental regulatory RNA",TRUE
+"243059_at",0.921727601757524,0.666002757987457,0.437473325881391,-5.84689538361744,0.214031254149883,"FENDRR","FOXF1 adjacent non-coding developmental regulatory RNA",TRUE
+"206412_at",0.769258076576208,0.27630778911653,1.11617159736684,-5.35044176077534,0.693405268612709,"FER","FER tyrosine kinase",TRUE
+"232064_at",0.790251550306366,0.319800746265728,1.01770963630197,-5.44742725282048,0.59653202626017,"FER","FER tyrosine kinase",TRUE
+"227579_at",0.804065713196639,0.342729793251901,0.969563520264698,-5.49190541200004,0.532664754386483,"FER","FER tyrosine kinase",TRUE
+"222245_s_at",0.270441084903894,0.00422417350723228,3.18807106531698,-1.92347807879003,1.22446397699797,"FER1L4","fer-1 like family member 4, pseudogene",TRUE
+"220388_at",0.412728274083545,0.0165819316714448,2.59201063810844,-3.10933315821103,2.0469332486494,"FER1L4","fer-1 like family member 4, pseudogene",TRUE
+"233353_at",0.920377252397623,0.661139083920881,0.444294278591304,-5.84399315222229,0.250703710578881,"FER1L5","fer-1 like family member 5",TRUE
+"1553443_at",0.812125226040016,0.356344906046235,0.942012137870068,-5.51647257071765,0.766813369624701,"FER1L6-AS1","FER1L6 antisense RNA 1",TRUE
+"1553517_at",0.996898592071515,0.984117140200993,-0.0201334349846657,-5.93948604910299,-0.00735802250667916,"FERD3L","Fer3-like bHLH transcription factor",TRUE
+"229545_at",0.0823353801878483,0.000301222309887237,4.27892386947459,0.401746296396815,2.16765240851435,"FERMT1","fermitin family member 1",TRUE
+"218796_at",0.18860161541457,0.00186826159445871,3.53002579724852,-1.2072662972317,4.42238512297073,"FERMT1","fermitin family member 1",TRUE
+"60474_at",0.199949563712201,0.0022253176430174,3.45728808556265,-1.36112124826913,3.8493814423415,"FERMT1","fermitin family member 1",TRUE
+"232479_at",0.94118897722809,0.736501828180211,0.34074974112482,-5.8832880869577,0.257947196739408,"FERMT1","fermitin family member 1",TRUE
+"209210_s_at",0.884769004468037,0.544746033111583,-0.615113838818331,-5.75705726668905,-0.431717938743375,"FERMT2","fermitin family member 2",TRUE
+"209209_s_at",0.939682421466574,0.729518671693076,-0.350169146605118,-5.88013639679541,-0.263888925713484,"FERMT2","fermitin family member 2",TRUE
+"214212_x_at",0.953983577550391,0.788255683682059,-0.271848314929679,-5.90375274526715,-0.172236240726194,"FERMT2","fermitin family member 2",TRUE
+"223303_at",0.875938621758472,0.524218559567416,-0.647094936125957,-5.73776705357112,-0.398762674157894,"FERMT3","fermitin family member 3",TRUE
+"205418_at",0.755868740464627,0.250211221336409,1.18077906671656,-5.2825003866723,0.824075042078888,"FES","FES proto-oncogene, tyrosine kinase",TRUE
+"210521_s_at",0.471611371152717,0.025687401249068,2.39163298437395,-3.48205274312805,1.65357851983558,"FETUB","fetuin B",TRUE
+"214417_s_at",0.83592051541604,0.41565038743104,0.829534199238419,-5.60996741370345,0.304537538189741,"FETUB","fetuin B",TRUE
+"210520_at",0.851733415458562,0.45602943722717,0.758696985954711,-5.66314256614515,0.482071615711351,"FETUB","fetuin B",TRUE
+"207260_at",0.940668681806864,0.734451185749585,0.343512504684546,-5.88237248367565,0.204135395531443,"FEV","FEV, ETS transcription factor",TRUE
+"203562_at",0.588653540532996,0.0673203172740028,1.92380309921707,-4.28184288531934,1.72833109889445,"FEZ1","fasciculation and elongation protein zeta 1",TRUE
+"205973_at",0.786455312223125,0.31215124340967,1.03430532100806,-5.43164381873216,0.718077625151063,"FEZ1","fasciculation and elongation protein zeta 1",TRUE
+"202305_s_at",0.630161231812663,0.101332922726967,1.70947912018936,-4.6085121106105,0.682180935107958,"FEZ2","fasciculation and elongation protein zeta 2",TRUE
+"215000_s_at",0.702109960609931,0.173565948378671,1.40609442154099,-5.02002331255834,0.652231409955919,"FEZ2","fasciculation and elongation protein zeta 2",TRUE
+"210704_at",0.784607101402888,0.308424864176338,1.04249352993289,-5.42377158910089,0.337589472861675,"FEZ2","fasciculation and elongation protein zeta 2",TRUE
+"233972_s_at",0.709914655587487,0.182747143656566,-1.37542587581192,-5.05801079045201,-0.799288944998429,"FEZF2","FEZ family zinc finger 2",TRUE
+"221086_s_at",0.75710709622615,0.252852737372001,-1.17401867405911,-5.28976667170932,-0.959522813810344,"FEZF2","FEZ family zinc finger 2",TRUE
+"233897_at",0.818247708976668,0.371253240358193,0.912645269512728,-5.5419421673949,0.57023688202802,"FEZF2","FEZ family zinc finger 2",TRUE
+"1561507_at",0.725583196024696,0.204499251054863,1.30734820565465,-5.1398299178998,0.643506813345023,"FFAR1","free fatty acid receptor 1",TRUE
+"231761_at",0.998870448604467,0.996101179499486,-0.00494189597030355,-5.93967158553679,-0.002362247531285,"FFAR1","free fatty acid receptor 1",TRUE
+"221345_at",0.774230543658252,0.286713265934061,-1.09165592800482,-5.37533716089457,-1.20290146218155,"FFAR2","free fatty acid receptor 2",TRUE
+"240856_at",0.851319596585235,0.454968818908967,-0.76050744817783,-5.66183922432479,-0.614047459652605,"FFAR4","free fatty acid receptor 4",TRUE
+"231671_at",0.800821301407998,0.336718443494622,0.981965678112197,-5.48063555939143,0.506926893539058,"FGA","fibrinogen alpha chain",TRUE
+"205649_s_at",0.915353407558177,0.642933264367811,0.470021118965514,-5.83265065019566,0.316389077795418,"FGA","fibrinogen alpha chain",TRUE
+"205650_s_at",0.987501658626956,0.941192481622484,0.0746126235491467,-5.93697234279152,0.0424038785588134,"FGA","fibrinogen alpha chain",TRUE
+"216238_s_at",0.765278605568716,0.265478190063324,-1.14241195642329,-5.32325303267294,-1.05943816271057,"FGB","fibrinogen beta chain",TRUE
+"204988_at",0.836752569023453,0.41856478270031,-0.824281986037724,-5.61406289612929,-0.644282514100495,"FGB","fibrinogen beta chain",TRUE
+"204819_at",0.899998627338565,0.594529600031093,0.540079554938362,-5.79860398187406,0.316286969930502,"FGD1","FYVE, RhoGEF and PH domain containing 1",TRUE
+"215602_at",0.545992239117952,0.0472033199475142,2.10134566322962,-3.99125145002306,1.21228891036534,"FGD2","FYVE, RhoGEF and PH domain containing 2",TRUE
+"1559091_s_at",0.738573426132641,0.22534133190227,1.24721560069478,-5.20916825009007,0.827779309773209,"FGD2","FYVE, RhoGEF and PH domain containing 2",TRUE
+"1553906_s_at",0.83030603167465,0.402677544323457,0.853200971939278,-5.59121154341887,0.799742572636362,"FGD2","FYVE, RhoGEF and PH domain containing 2",TRUE
+"1565752_at",0.83242103542195,0.408659628387909,0.842228316619141,-5.59996859971112,0.519940018366159,"FGD2","FYVE, RhoGEF and PH domain containing 2",TRUE
+"1565751_at",0.86373265375983,0.48924410164183,0.703217750705094,-5.70165164255791,0.314134360499029,"FGD2","FYVE, RhoGEF and PH domain containing 2",TRUE
+"1565754_x_at",0.974424905435949,0.874781381955521,-0.159421169546677,-5.92731229413811,-0.0681400585022711,"FGD2","FYVE, RhoGEF and PH domain containing 2",TRUE
+"242632_at",0.998347572104896,0.992012468411852,0.0101246228355917,-5.93963355301112,0.00734140146036477,"FGD2","FYVE, RhoGEF and PH domain containing 2",TRUE
+"1555407_s_at",0.951568785371415,0.777962362855594,0.28543479216207,-5.90007870017549,0.217866184265562,"FGD3","FYVE, RhoGEF and PH domain containing 3",TRUE
+"227811_at",0.967106491969364,0.846755351846618,0.195536144818746,-5.92107806163812,0.164138524384509,"FGD3","FYVE, RhoGEF and PH domain containing 3",TRUE
+"227948_at",0.831893282610777,0.407818576189703,0.843764800271462,-5.59874873095635,0.37298624716858,"FGD4","FYVE, RhoGEF and PH domain containing 4",TRUE
+"242445_at",0.875891766935648,0.523869548201857,0.647644503235121,-5.73742735568479,0.250164434616444,"FGD4","FYVE, RhoGEF and PH domain containing 4",TRUE
+"230559_x_at",0.994098505325585,0.972916525285268,0.0343361875336179,-5.93910926240669,0.0198754183746743,"FGD4","FYVE, RhoGEF and PH domain containing 4",TRUE
+"226985_at",0.842745573994811,0.436547602134084,0.792369355395508,-5.63842238350758,0.416243115508204,"FGD5","FYVE, RhoGEF and PH domain containing 5",TRUE
+"226984_at",0.924812035112346,0.674787913131235,0.425205760979614,-5.85200411209792,0.143135207503675,"FGD5","FYVE, RhoGEF and PH domain containing 5",TRUE
+"224644_at",0.710824498521146,0.184129518306743,-1.37091482057539,-5.06353974798562,-0.494835244148476,"FGD5-AS1","FGD5 antisense RNA 1",TRUE
+"1561546_at",0.915939421175188,0.645167803317075,0.466846432902619,-5.83408413203456,0.194371881262152,"FGD5-AS1","FGD5 antisense RNA 1",TRUE
+"1555137_a_at",0.332566035407083,0.00818717665583783,2.9042261933544,-2.5004596344664,1.52112067408766,"FGD6","FYVE, RhoGEF and PH domain containing 6",TRUE
+"219901_at",0.346761268605178,0.00889893121608451,2.86792580499078,-2.57278348371716,1.4843421930201,"FGD6","FYVE, RhoGEF and PH domain containing 6",TRUE
+"226799_at",0.462049949204478,0.0232706673302586,2.43740738146223,-3.39831472410336,1.82030803837794,"FGD6","FYVE, RhoGEF and PH domain containing 6",TRUE
+"243142_at",0.620223198657182,0.0901677680185461,1.77188258567109,-4.51628762397207,1.56144907609553,"FGD6","FYVE, RhoGEF and PH domain containing 6",TRUE
+"1555136_at",0.671298718565642,0.137100514627584,1.54255911693377,-4.84275836114033,1.01467025381738,"FGD6","FYVE, RhoGEF and PH domain containing 6",TRUE
+"205117_at",0.805746717966166,0.345864611441709,-0.963154946044888,-5.49767764901635,-0.751169422019784,"FGF1","fibroblast growth factor 1",TRUE
+"1552721_a_at",0.995907002998101,0.980059923115003,0.0252774740148813,-5.93937227621653,0.0301971209700351,"FGF1","fibroblast growth factor 1",TRUE
+"208240_s_at",0.997608949249317,0.988146416762148,0.015025372329244,-5.93957352109165,0.0111817505262204,"FGF1","fibroblast growth factor 1",TRUE
+"231762_at",0.955730092376044,0.797607973608791,-0.2595491624533,-5.90692525964268,-0.1925693969064,"FGF10","fibroblast growth factor 10",TRUE
+"1562691_at",0.567293479905907,0.057512716216158,2.00341543442754,-4.1536549137769,1.4281383654002,"FGF10-AS1","FGF10 antisense RNA 1",TRUE
+"227271_at",0.0823353801878483,0.000302442205492644,4.27727525407829,0.398183713853716,2.02378465989897,"FGF11","fibroblast growth factor 11",TRUE
+"231803_at",0.573831063059214,0.0603887671207557,1.97889765951671,-4.19350787471181,1.03674208403621,"FGF11","fibroblast growth factor 11",TRUE
+"214589_at",0.635368778245437,0.106287542407004,-1.68365062490535,-4.6459596412753,-1.70842270399935,"FGF12","fibroblast growth factor 12",TRUE
+"207501_s_at",0.903678874758741,0.605184485292297,-0.524433801171687,-5.80660668727259,-0.46489615172651,"FGF12","fibroblast growth factor 12",TRUE
+"238521_at",0.994701128358967,0.975366265978993,0.031229320219145,-5.93920847363907,0.0262036514054973,"FGF12","fibroblast growth factor 12",TRUE
+"205110_s_at",0.432151440378733,0.0193608784794777,-2.52176022647282,-3.24178267282779,-3.24616692375871,"FGF13","fibroblast growth factor 13",TRUE
+"1560537_at",0.859483694145165,0.477050784933211,-0.723319699452814,-5.68801936684512,-0.514368777339014,"FGF13-AS1","FGF13 antisense RNA 1",TRUE
+"230231_at",0.606363554544506,0.0800277898416672,1.83460758208215,-4.4211581562096,1.25427186780877,"FGF14","fibroblast growth factor 14",TRUE
+"221310_at",0.835973067952943,0.417158305010242,-0.826813799989012,-5.6120917202805,-0.60199251007954,"FGF14","fibroblast growth factor 14",TRUE
+"231523_at",0.906878681039516,0.615249898869975,-0.509774450194859,-5.81389691527191,-0.391164113652104,"FGF14","fibroblast growth factor 14",TRUE
+"230288_at",0.933448396773721,0.705537287833551,0.382770589057219,-5.86857310242397,0.205682354709765,"FGF14","fibroblast growth factor 14",TRUE
+"233185_at",0.988065316951061,0.942965063783256,-0.0723594720524434,-5.93713359195943,-0.0228260481614884,"FGF14","fibroblast growth factor 14",TRUE
+"230351_at",0.720018659171833,0.195995330659936,1.33325360443341,-5.10910649664869,1.27189440480543,"FGF14-AS2","FGF14 antisense RNA 2",TRUE
+"243225_at",0.937113154905832,0.719982670828754,0.363084573906715,-5.87567693844083,0.270808901879091,"FGF14-AS2","FGF14 antisense RNA 2",TRUE
+"237392_at",0.594005743610726,0.0710095126667076,1.89648808399865,-4.32499917657712,1.73359382911092,"FGF14-IT1","FGF14 intronic transcript 1",TRUE
+"221374_at",0.776696310319783,0.294100479424791,-1.07463885406106,-5.39232816248633,-0.790067999367419,"FGF16","fibroblast growth factor 16",TRUE
+"221376_at",0.732320150624823,0.216647609478117,1.27175486204206,-5.18120875083354,0.610562083034326,"FGF17","fibroblast growth factor 17",TRUE
+"206986_at",0.711902920992134,0.185568612980271,1.36624705198417,-5.06924486433071,0.608286623616611,"FGF18","fibroblast growth factor 18",TRUE
+"211029_x_at",0.813442508625161,0.363876826797639,-0.927075000830583,-5.52952013612842,-1.11249807116903,"FGF18","fibroblast growth factor 18",TRUE
+"206987_x_at",0.867972140419125,0.501620135222858,-0.683107358481061,-5.71492291047046,-0.812271080943883,"FGF18","fibroblast growth factor 18",TRUE
+"231382_at",0.898623566722697,0.588267667126452,-0.549338431253519,-5.79376041224513,-0.529008414565469,"FGF18","fibroblast growth factor 18",TRUE
+"211485_s_at",0.927934056345262,0.683707646404488,-0.412817765081713,-5.85701806441216,-0.428501101728782,"FGF18","fibroblast growth factor 18",TRUE
+"214284_s_at",0.974451535839172,0.874977116684744,-0.159169759913623,-5.92735125869093,-0.128507456090196,"FGF18","fibroblast growth factor 18",TRUE
+"223761_at",0.937113154905832,0.720233386159449,0.362744211580465,-5.87579650552407,0.248217544814059,"FGF19","fibroblast growth factor 19",TRUE
+"204421_s_at",0.813246709148981,0.363094017686983,0.928617742637239,-5.52818143145278,1.2120615582069,"FGF2","fibroblast growth factor 2",TRUE
+"204422_s_at",0.93950030622033,0.729021307575742,0.350841251972621,-5.87990826695002,0.545176157638105,"FGF2","fibroblast growth factor 2",TRUE
+"220394_at",0.833129975086556,0.410386035464676,0.839080705508051,-5.60246111641418,0.666483402113122,"FGF20","fibroblast growth factor 20",TRUE
+"221433_at",0.651332373348922,0.120907446031583,1.61295720745139,-4.74623056535848,0.982545922738222,"FGF21","fibroblast growth factor 21",TRUE
+"221315_s_at",0.925375904025762,0.676593817045163,-0.422692262475843,-5.85303321659968,-0.333829514430131,"FGF22","fibroblast growth factor 22",TRUE
+"1566814_at",0.95238233774064,0.782155293308727,0.279893934335818,-5.90159852484347,0.175838203537699,"FGF22","fibroblast growth factor 22",TRUE
+"1566816_at",0.963454248538906,0.833266777332588,-0.213010095801403,-5.91760795114719,-0.105668687258837,"FGF22","fibroblast growth factor 22",TRUE
+"221166_at",0.846615322073696,0.445035450345922,0.777588772910683,-5.64939805140689,0.39338211177766,"FGF23","fibroblast growth factor 23",TRUE
+"214571_at",0.683017520100356,0.151446287843233,1.48571124196617,-4.91821146240197,0.64677678380687,"FGF3","fibroblast growth factor 3",TRUE
+"1552982_a_at",0.866197674833253,0.496996006877001,-0.690587843708972,-5.71002932154438,-0.942668115176806,"FGF4","fibroblast growth factor 4",TRUE
+"206783_at",0.969946179106301,0.85771071178125,0.181389836148269,-5.92367069129952,0.130346764792073,"FGF4","fibroblast growth factor 4",TRUE
+"210311_at",0.904832003218088,0.609792976907493,-0.517707705342955,-5.80997663954529,-0.292966441676263,"FGF5","fibroblast growth factor 5",TRUE
+"210310_s_at",0.980001024522674,0.905044972241877,0.120663682232385,-5.93259446308936,0.139479407203295,"FGF5","fibroblast growth factor 5",TRUE
+"208378_x_at",0.984004604128855,0.921520534583572,-0.0996471977759479,-5.93484831318638,-0.0931690011019137,"FGF5","fibroblast growth factor 5",TRUE
+"208417_at",0.976630318884229,0.888746987034016,0.141508530613432,-5.92993490904237,0.0751441027352033,"FGF6","fibroblast growth factor 6",TRUE
+"1555102_at",0.737161440695888,0.223275220539812,-1.25298093791949,-5.20264132597358,-0.585985098955368,"FGF7","fibroblast growth factor 7",TRUE
+"1555103_s_at",0.831875452294783,0.407344073089865,0.844632541059345,-5.59805888387173,0.951972408831954,"FGF7","fibroblast growth factor 7",TRUE
+"205782_at",0.892539759441136,0.564793609458517,0.584492608075771,-5.77464330685489,0.307725449777307,"FGF7","fibroblast growth factor 7",TRUE
+"231031_at",0.289816987027404,0.00500290699714945,-3.11615409002966,-2.07142484452719,-2.37148120551699,"FGF7P3","fibroblast growth factor 7 pseudogene 3",TRUE
+"1554741_s_at",0.826134344333512,0.393903675945512,-0.869485236102538,-5.57802085643004,-0.632594625059697,"FGF7P3///FGF7P6///FGF7","fibroblast growth factor 7 pseudogene 3///fibroblast growth factor 7 pseudogene 6///fibroblast growth factor 7",TRUE
+"208449_s_at",0.39259320496653,0.0133570327607874,-2.68895341465744,-2.92364524987421,-1.01711631902083,"FGF8","fibroblast growth factor 8",TRUE
+"239178_at",0.484287917564084,0.0277684978795318,-2.35530043784413,-3.54788954446373,-3.19748418506031,"FGF9","fibroblast growth factor 9",TRUE
+"206404_at",0.651636743353835,0.121056364554013,-1.61227494918011,-4.74718215338432,-2.04593957528428,"FGF9","fibroblast growth factor 9",TRUE
+"205014_at",0.00923700177636659,4.56148235869955e-06,6.01569763340082,4.05255116865792,4.15095434969746,"FGFBP1","fibroblast growth factor binding protein 1",TRUE
+"223836_at",0.992473381533485,0.964920961311435,0.0444790837992971,-5.93871992640016,0.0446901935733708,"FGFBP2","fibroblast growth factor binding protein 2",TRUE
+"238453_at",0.933880100915183,0.707135549664172,0.380585044935077,-5.86938002467895,0.263521314290885,"FGFBP3","fibroblast growth factor binding protein 3",TRUE
+"226705_at",0.497725944448536,0.0307161832332996,-2.30791260852872,-3.63289673290001,-1.82238410627016,"FGFR1","fibroblast growth factor receptor 1",TRUE
+"211535_s_at",0.593337376134677,0.0700393127676855,-1.90354858261536,-4.31388511957202,-1.50043889596588,"FGFR1","fibroblast growth factor receptor 1",TRUE
+"210973_s_at",0.620912785033482,0.0909966906979968,-1.76702843875759,-4.52354892873672,-1.64507877206949,"FGFR1","fibroblast growth factor receptor 1",TRUE
+"207937_x_at",0.803706747165017,0.34229749089135,-0.970450420206998,-5.4911038232709,-0.45518152816064,"FGFR1","fibroblast growth factor receptor 1",TRUE
+"207822_at",0.818598668505758,0.372071248487181,-0.911056860358443,-5.54329859432423,-0.748110574967681,"FGFR1","fibroblast growth factor receptor 1",TRUE
+"222164_at",0.89203601623083,0.562322371261632,-0.588236333205066,-5.7725398110187,-0.264166844783807,"FGFR1","fibroblast growth factor receptor 1",TRUE
+"215404_x_at",0.978428568803085,0.896201744074157,-0.131966623652278,-5.93120474204061,-0.0430630465636153,"FGFR1","fibroblast growth factor receptor 1",TRUE
+"1568678_s_at",0.763650705722297,0.26346917318014,1.14736590478089,-5.31805753842236,0.360724359247566,"FGFR1OP","FGFR1 oncogene partner",TRUE
+"205588_s_at",0.767965891104819,0.271008093477081,1.12891689969091,-5.33730552772328,0.375048668704858,"FGFR1OP","FGFR1 oncogene partner",TRUE
+"214124_x_at",0.851733415458562,0.456605613322759,0.757714521783068,-5.66384860688123,0.359230725960741,"FGFR1OP","FGFR1 oncogene partner",TRUE
+"239434_at",0.90427866743639,0.606723757681693,0.522184522306358,-5.80773835119724,0.429997460844587,"FGFR1OP","FGFR1 oncogene partner",TRUE
+"205587_at",0.99753019043878,0.987508891346923,-0.0158335559685457,-5.93956137403204,-0.00848452411376677,"FGFR1OP","FGFR1 oncogene partner",TRUE
+"1556283_s_at",0.597654932724127,0.0741397880742259,1.8742696912822,-4.35978458551582,1.07904704475018,"FGFR1OP2","FGFR1 oncogene partner 2",TRUE
+"236808_at",0.724067243569133,0.201112733837941,1.31756194776901,-5.12777730875865,0.54321983879205,"FGFR1OP2","FGFR1 oncogene partner 2",TRUE
+"1556282_at",0.815028680506658,0.365905181600597,0.923087856353812,-5.53297046750872,0.760831069525088,"FGFR1OP2","FGFR1 oncogene partner 2",TRUE
+"223263_s_at",0.930899509890345,0.694121606448742,0.39843706125047,-5.86265560237106,0.148436352086694,"FGFR1OP2","FGFR1 oncogene partner 2",TRUE
+"233898_s_at",0.931370027472813,0.695788801909759,0.396142818388647,-5.86353679166179,0.166893476838592,"FGFR1OP2","FGFR1 oncogene partner 2",TRUE
+"223262_s_at",0.978276691813018,0.895474878526154,0.132896427352791,-5.93108489400579,0.0600357177182236,"FGFR1OP2","FGFR1 oncogene partner 2",TRUE
+"243619_at",0.979415860312329,0.900994767576002,0.125838348147823,-5.93197363686731,0.128564089165515,"FGFR1OP2","FGFR1 oncogene partner 2",TRUE
+"211399_at",0.643082025527735,0.113642509431696,1.64712862546359,-4.6981730072462,0.87338123163706,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"211398_at",0.7168525499531,0.192847451402261,-1.34306603403457,-5.09733670729469,-0.725880792954704,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"208229_at",0.775121983908223,0.291562116525954,-1.08045117303507,-5.38655153920597,-0.430770093020074,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"203638_s_at",0.812302873476553,0.357573869817845,-0.939560501591634,-5.51862720901221,-1.69960764230437,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"211400_at",0.812302873476553,0.358733028444861,-0.937253308485373,-5.52065019422476,-0.595590417095484,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"240913_at",0.835952408568777,0.41603514085378,-0.828839483695996,-5.61051052428146,-0.432057733621916,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"211401_s_at",0.858826390511142,0.474842274836277,-0.726992561561292,-5.68548910854423,-1.05799737852099,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"208228_s_at",0.886916043359667,0.550544867124165,-0.606196719874133,-5.76226790424666,-0.634564970518559,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"208234_x_at",0.928875638460009,0.686831276196862,-0.408495159489547,-5.85873329278354,-0.400595732754542,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"208225_at",0.956734254923335,0.803805645304975,-0.251421232720257,-5.90894175001477,-0.158298131071541,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"203639_s_at",0.988438753637362,0.94486971118165,-0.0699388781602941,-5.93730131822189,-0.106667794634273,"FGFR2","fibroblast growth factor receptor 2",TRUE
+"204380_s_at",0.892643596418532,0.565049725364746,0.584105095943835,-5.77486029717193,0.300612223601179,"FGFR3","fibroblast growth factor receptor 3",TRUE
+"204379_s_at",0.931370027472813,0.696244990064334,-0.395515431107223,-5.86377689037168,-0.488237795495463,"FGFR3","fibroblast growth factor receptor 3",TRUE
+"211237_s_at",0.380084968057051,0.0117140189312545,-2.74720914699816,-2.81053413244009,-4.20220963398916,"FGFR4","fibroblast growth factor receptor 4",TRUE
+"1554961_at",0.419258213999957,0.0172840971990106,-2.5732749530135,-3.14483619148856,-2.03738730186773,"FGFR4","fibroblast growth factor receptor 4",TRUE
+"204579_at",0.682539393883246,0.150438175835737,-1.48955881653177,-4.91317627572288,-1.61806282999593,"FGFR4","fibroblast growth factor receptor 4",TRUE
+"1554962_a_at",0.725276957219979,0.204150170970209,-1.3083949205901,-5.1385984017616,-1.16418545335863,"FGFR4","fibroblast growth factor receptor 4",TRUE
+"223321_s_at",0.82750481665844,0.396309348407887,-0.864997254660835,-5.58167940135819,-0.402309135876594,"FGFRL1","fibroblast growth factor receptor-like 1",TRUE
+"223648_s_at",0.842167419664876,0.435452663231824,-0.794288871369221,-5.63698272748441,-0.644890487397846,"FGFRL1","fibroblast growth factor receptor-like 1",TRUE
+"219612_s_at",0.861357981297227,0.481748623196876,0.715539880306369,-5.69333868304661,0.653453533666467,"FGG","fibrinogen gamma chain",TRUE
+"232380_at",0.8288884913487,0.399707996086674,-0.858686647185684,-5.58679392912902,-0.705617021896065,"FGGY","FGGY carbohydrate kinase domain containing",TRUE
+"219718_at",0.97897951922649,0.898170912172136,-0.12944826721179,-5.9315251293105,-0.06487279213448,"FGGY","FGGY carbohydrate kinase domain containing",TRUE
+"205305_at",0.784925710185113,0.310214720751966,1.03855190358282,-5.4275680882124,0.404831446072075,"FGL1","fibrinogen like 1",TRUE
+"204834_at",0.816800680706682,0.368174089726477,-0.918645283120614,-5.53679877971345,-0.685055837605883,"FGL2","fibrinogen like 2",TRUE
+"227265_at",0.889389445320988,0.557070993983042,-0.596220090970866,-5.76801058823746,-0.43221544813724,"FGL2","fibrinogen like 2",TRUE
+"208438_s_at",0.797896456623304,0.331891588525236,-0.99203466640641,-5.47138994642085,-0.663635546366355,"FGR","FGR proto-oncogene, Src family tyrosine kinase",TRUE
+"203033_x_at",0.767232419466657,0.269230561937333,-1.13323252666184,-5.33282766067974,-0.406718680422374,"FH","fumarate hydratase",TRUE
+"203032_s_at",0.859502367311367,0.47744383164186,-0.72266708763237,-5.68846768071532,-0.251749875237333,"FH","fumarate hydratase",TRUE
+"214170_x_at",0.921729477898827,0.666451471332992,-0.43684510395726,-5.84716046774118,-0.162329216654825,"FH","fumarate hydratase",TRUE
+"1564635_a_at",0.125435270053452,0.000745614316732909,3.908591762262,-0.397664474986462,2.7242723331055,"FHAD1","forkhead associated phosphopeptide binding domain 1",TRUE
+"1563830_a_at",0.592111379991983,0.069166659654291,1.9099728340488,-4.30374759273348,1.5813882586647,"FHAD1","forkhead associated phosphopeptide binding domain 1",TRUE
+"1557771_at",0.736330422786726,0.22182764712693,1.25704463252957,-5.19802530994266,0.866687034884458,"FHAD1","forkhead associated phosphopeptide binding domain 1",TRUE
+"1560097_at",0.808233282592165,0.350326321671024,0.954101611980761,-5.5057723811059,0.729120879391684,"FHAD1","forkhead associated phosphopeptide binding domain 1",TRUE
+"1563961_at",0.896159990898752,0.578785718666701,0.563451767355142,-5.786223574046,0.283445534586027,"FHAD1","forkhead associated phosphopeptide binding domain 1",TRUE
+"1563639_a_at",0.941658863259145,0.738636006741563,0.337877300463485,-5.88423228536043,0.0963415558640435,"FHAD1","forkhead associated phosphopeptide binding domain 1",TRUE
+"226599_at",0.858826390511142,0.475079202627005,-0.726598060001236,-5.68576146701592,-0.301559831196034,"FHDC1","FH2 domain containing 1",TRUE
+"206492_at",0.774230543658252,0.290285825875365,-1.08338734863013,-5.38362281990961,-0.489911720924246,"FHIT","fragile histidine triad",TRUE
+"214505_s_at",0.580630437263151,0.0632914687577864,1.95517962423761,-4.23174467551946,2.89291187509355,"FHL1","four and a half LIM domains 1",TRUE
+"201539_s_at",0.617775129514679,0.0888291606958269,1.77980306739111,-4.50440808815102,1.23232289568156,"FHL1","four and a half LIM domains 1",TRUE
+"210298_x_at",0.634292762720105,0.105466035772995,1.68786149679213,-4.63988380788856,2.28423746279729,"FHL1","four and a half LIM domains 1",TRUE
+"210299_s_at",0.666643938027574,0.133458317174778,1.55776732007257,-4.82219171517859,2.18998412607734,"FHL1","four and a half LIM domains 1",TRUE
+"201540_at",0.667796492642767,0.13412113919909,1.55497436683125,-4.82598067020431,2.06934501020918,"FHL1","four and a half LIM domains 1",TRUE
+"202949_s_at",0.78969417320323,0.31747434636915,1.02272704942335,-5.44267972623223,1.20727567445715,"FHL2","four and a half LIM domains 2",TRUE
+"218818_at",0.777578982671021,0.296596427683661,1.06895860712537,-5.39794660740681,0.714483399602805,"FHL3","four and a half LIM domains 3",TRUE
+"220170_at",0.539114280228505,0.0441944093433667,2.13355460054711,-3.9367462797786,1.8107066934926,"FHL5","four and a half LIM domains 5",TRUE
+"1555191_a_at",0.835973067952943,0.417147667258789,-0.826832969576509,-5.61207677397068,-0.398446805892445,"FHL5","four and a half LIM domains 5",TRUE
+"1570517_at",0.911442048875632,0.629615998975468,0.489044893772382,-5.82386167083882,0.241209124614874,"FHL5","four and a half LIM domains 5",TRUE
+"218530_at",0.702888118552354,0.174727249149493,-1.40214491786128,-5.02495418387632,-0.910167600520479,"FHOD1","formin homology 2 domain containing 1",TRUE
+"218980_at",0.171206734275901,0.00148113004686787,3.62621825293209,-1.00280515073794,5.22625244117573,"FHOD3","formin homology 2 domain containing 3",TRUE
+"238943_at",0.906476756086155,0.613728810276263,-0.511982452676762,-5.81281174207634,-0.559198594302621,"FIBCD1","fibrinogen C domain containing 1",TRUE
+"240042_at",0.928295253101366,0.685037389415789,-0.410976639548743,-5.85775080253894,-0.49295549105701,"FIBCD1","fibrinogen C domain containing 1",TRUE
+"226769_at",0.921753044974925,0.666545041411498,0.436714123517473,-5.84721568904885,0.345690138815955,"FIBIN","fin bud initiation factor homolog (zebrafish)",TRUE
+"231001_at",0.971216837324271,0.862835838252311,-0.174785085531104,-5.9248147316846,-0.0897796410904048,"FIBIN","fin bud initiation factor homolog (zebrafish)",TRUE
+"202041_s_at",0.698445705579474,0.169702293683364,-1.41938830478012,-5.00334232368459,-0.455172694568148,"FIBP","FGF1 intracellular binding protein",TRUE
+"219910_at",0.965707350334601,0.839755185665994,-0.204596476017544,-5.91931569723847,-0.0520610382018134,"FICD","FIC domain containing",TRUE
+"203656_at",0.83816016450855,0.422766913887824,0.816749390092046,-5.61989400533625,0.350663424058737,"FIG4","FIG4 phosphoinositide 5-phosphatase",TRUE
+"1570337_at",0.586576404049536,0.0661311802529529,-1.93288807465828,-4.26739443927828,-1.37604698885478,"FIGLA","folliculogenesis specific bHLH transcription factor",TRUE
+"222956_at",0.6708432030569,0.1367897995492,1.5438434310029,-4.84102769874018,1.89687376079855,"FIGN","fidgetin, microtubule severing factor",TRUE
+"242828_at",0.725181883744124,0.203836027186096,1.30933806957137,-5.13748802229774,1.34541246138487,"FIGN","fidgetin, microtubule severing factor",TRUE
+"239710_at",0.768852835478002,0.274055994829003,1.12156495450416,-5.34489908143568,1.26737882745979,"FIGN","fidgetin, microtubule severing factor",TRUE
+"238964_at",0.839519981963042,0.426809821067429,0.809546330398543,-5.62542306404657,0.80934287585174,"FIGN","fidgetin, microtubule severing factor",TRUE
+"1552921_a_at",0.951934441578502,0.780080280112126,0.282634885418012,-5.90085039310247,0.0907790461213676,"FIGNL1","fidgetin like 1",TRUE
+"222843_at",0.995623666221824,0.979167673535245,0.0264088226459101,-5.93934379600958,0.00835930381590799,"FIGNL1","fidgetin like 1",TRUE
+"231945_at",0.727533149623979,0.207874217895305,1.29729927907043,-5.15161052142286,0.834002906455038,"FILIP1","filamin A interacting protein 1",TRUE
+"1556325_at",0.756601922352523,0.252052258518579,1.17606174597338,-5.28757455744092,1.10951760812148,"FILIP1","filamin A interacting protein 1",TRUE
+"1570515_a_at",0.971216837324271,0.862945152352299,0.174644300151512,-5.92483865733086,0.169484750386662,"FILIP1","filamin A interacting protein 1",TRUE
+"235183_at",0.983364220761052,0.919057185466327,-0.102786326790144,-5.93453895443835,-0.0750338767097309,"FILIP1","filamin A interacting protein 1",TRUE
+"204135_at",0.538307479093131,0.0438407287699633,-2.13746939267915,-3.93008571650288,-1.73535568245267,"FILIP1L","filamin A interacting protein 1 like",TRUE
+"1554966_a_at",0.595419021493991,0.072114581807649,-1.88854829392661,-4.3374628380898,-1.98029282763506,"FILIP1L","filamin A interacting protein 1 like",TRUE
+"1554965_at",0.61591966964196,0.0870247494351741,1.79064393894674,-4.4880857238688,0.931223987947165,"FILIP1L","filamin A interacting protein 1 like",TRUE
+"227293_at",0.805746717966166,0.345319065449333,-0.964267362245741,-5.49667819816347,-0.401103000051536,"FIP1L1","factor interacting with PAPOLA and CPSF1",TRUE
+"221007_s_at",0.92051722798026,0.661845525462035,-0.443302222637311,-5.84441799800742,-0.118307434269289,"FIP1L1","factor interacting with PAPOLA and CPSF1",TRUE
+"1554424_at",0.990810941805126,0.95666845199999,-0.0549529618658771,-5.93821274089427,-0.0183516935803052,"FIP1L1","factor interacting with PAPOLA and CPSF1",TRUE
+"1558791_at",0.807824562181406,0.349252071346028,0.956274201633474,-5.50383621208619,0.523152212492982,"FIRRE","firre intergenic repeating RNA element",TRUE
+"218034_at",0.854810562588402,0.466815758287424,-0.740426367138881,-5.6761308373461,-0.347114187324133,"FIS1","fission, mitochondrial 1",TRUE
+"229567_at",0.743553048228796,0.234141466642623,1.22310117775882,-5.23618706677553,0.591063013017039,"FITM1","fat storage inducing transmembrane protein 1",TRUE
+"232186_at",0.0714488726114362,0.000212352306093728,-4.42152152378102,0.709769058671233,-2.57591599671678,"FITM2","fat storage inducing transmembrane protein 2",TRUE
+"226805_at",0.206592183249774,0.00234270056908752,-3.43585680312646,-1.40631572483716,-1.35013396491864,"FITM2","fat storage inducing transmembrane protein 2",TRUE
+"233061_at",0.698391916012681,0.169605381166895,-1.41972485806917,-5.00291834689663,-0.486594137013414,"FITM2","fat storage inducing transmembrane protein 2",TRUE
+"228663_x_at",0.550213045400235,0.0487285762612302,-2.08571766549091,-4.01750639270493,-0.670644119064054,"FIZ1","FLT3 interacting zinc finger 1",TRUE
+"226967_at",0.812896635201594,0.361969913005709,-0.930836998603248,-5.52625209532621,-0.295974380603832,"FIZ1","FLT3 interacting zinc finger 1",TRUE
+"219522_at",0.823074246722209,0.389412333190493,0.87791194219961,-5.57110400175776,0.776032365597493,"FJX1","four jointed box 1",TRUE
+"219249_s_at",0.70628982896028,0.178358366135429,1.38992926316463,-5.04013264250893,2.37381501718414,"FKBP10","FK506 binding protein 10",TRUE
+"219118_at",0.710657275720264,0.183594586548674,1.37265725426084,-5.06140593142977,1.06534641533389,"FKBP11","FK506 binding protein 11",TRUE
+"219117_s_at",0.837345289209351,0.42016917848502,0.821400423720181,-5.61629948483057,0.552771418807794,"FKBP11","FK506 binding protein 11",TRUE
+"228308_at",0.968035667633768,0.849192588582685,-0.19238558939874,-5.92167225742247,-0.069320791713384,"FKBP11","FK506 binding protein 11",TRUE
+"219390_at",0.637485146909712,0.108357411740683,1.67316184496738,-4.66104387331406,0.891314848534707,"FKBP14","FK506 binding protein 14",TRUE
+"230728_at",0.697340169581683,0.167718760493811,1.42630754352765,-4.99460915809495,0.744600842497155,"FKBP14","FK506 binding protein 14",TRUE
+"235311_at",0.852006864319744,0.457417913759695,0.75633069543601,-5.66484161554365,0.369545637571552,"FKBP14","FK506 binding protein 14",TRUE
+"231099_at",0.732899901507595,0.217088503062012,1.27049236497037,-5.18265858474926,0.939472833700771,"FKBP15","FK506 binding protein 15",TRUE
+"31826_at",0.85334340854827,0.461338285421468,-0.749672615010161,-5.66959531201844,-0.239251871794078,"FKBP15","FK506 binding protein 15",TRUE
+"212663_at",0.868045863234681,0.501925815448332,-0.682614237900265,-5.71524371094036,-0.219343230702938,"FKBP15","FK506 binding protein 15",TRUE
+"1568717_a_at",0.877861946695164,0.529370911331779,-0.639004990970414,-5.74273554286922,-0.392939741192515,"FKBP15","FK506 binding protein 15",TRUE
+"242574_at",0.977874971442423,0.893163323070299,-0.135854162291873,-5.93069806764861,-0.0983663083699367,"FKBP15","FK506 binding protein 15",TRUE
+"76897_s_at",0.990810941805126,0.954841739076272,0.0572721898081199,-5.93808598943761,0.0216020964790351,"FKBP15","FK506 binding protein 15",TRUE
+"233565_s_at",0.789795896476304,0.318508074933694,1.02049441156965,-5.44479487659191,0.814736261587709,"FKBP1A-SDCBP2///SDCBP2","FKBP1A-SDCBP2 readthrough (NMD candidate)///syndecan binding protein 2",TRUE
+"206857_s_at",0.369429132228615,0.011016850549407,2.77430297874643,-2.75755777937269,2.71535202438361,"FKBP1B","FK506 binding protein 1B",TRUE
+"203391_at",0.96235202680247,0.828582014846388,0.219094656305773,-5.91633025619031,0.0761446226786511,"FKBP2","FK506 binding protein 2",TRUE
+"218003_s_at",0.710630811817636,0.183509765561101,-1.37293391071985,-5.06106692540259,-0.485340182596373,"FKBP3","FK506 binding protein 3",TRUE
+"222485_at",0.942684843065067,0.743251883908901,-0.331674548437986,-5.88624421705002,-0.175315607484925,"FKBP3","FK506 binding protein 3",TRUE
+"239351_at",0.991059530537351,0.958282110419447,-0.0529044891290843,-5.93832033901838,-0.0381132566154196,"FKBP3","FK506 binding protein 3",TRUE
+"200895_s_at",0.543311492243675,0.0462864739444859,-2.11095950502948,-3.97503785219702,-1.07039088105843,"FKBP4","FK506 binding protein 4",TRUE
+"200894_s_at",0.582980484640151,0.0644927394429053,-1.94564424801607,-4.24702842128202,-1.07151168770385,"FKBP4","FK506 binding protein 4",TRUE
+"1560303_at",0.89961817630669,0.590745155627601,-0.545669460776179,-5.79568931998027,-0.294826000381779,"FKBP4","FK506 binding protein 4",TRUE
+"1560305_x_at",0.949038895598021,0.770173937981229,-0.295751425235183,-5.89717017040024,-0.194575125340324,"FKBP4","FK506 binding protein 4",TRUE
+"204560_at",0.65284137151906,0.122119476088292,-1.60742466260495,-4.75393815924625,-2.27809124093435,"FKBP5","FK506 binding protein 5",TRUE
+"224840_at",0.718706241731185,0.194712085242209,-1.3372386525439,-5.10433525949943,-1.05495781478774,"FKBP5","FK506 binding protein 5",TRUE
+"224856_at",0.75959865506602,0.257402675930303,-1.16249630913167,-5.30206711767359,-0.775486427781219,"FKBP5","FK506 binding protein 5",TRUE
+"206763_at",0.817202102194645,0.36962794672654,0.915808169330748,-5.53923470949541,0.288984082726416,"FKBP6","FK506 binding protein 6",TRUE
+"224002_s_at",0.83024704628409,0.402030100550237,0.854394782960968,-5.59025241284804,0.47939272331543,"FKBP7","FK506 binding protein 7",TRUE
+"223667_at",0.859465912277024,0.476609244707387,0.724053204901393,-5.68751502365075,0.776656362288438,"FKBP7","FK506 binding protein 7",TRUE
+"231130_at",0.870852305833096,0.510581368604829,0.668720797031014,-5.72419101536588,0.702815068073279,"FKBP7","FK506 binding protein 7",TRUE
+"40850_at",0.859947009633611,0.478384112050201,0.721107126569614,-5.68953774207067,0.344626091939798,"FKBP8","FK506 binding protein 8",TRUE
+"208255_s_at",0.94333312187812,0.74556612455613,0.328569706747916,-5.88723745500976,0.112495881460609,"FKBP8","FK506 binding protein 8",TRUE
+"222007_s_at",0.973669917754054,0.873230990710014,-0.161412928095885,-5.92700143469475,-0.0758225784508655,"FKBP8","FK506 binding protein 8",TRUE
+"212169_at",0.819018525257656,0.373714043839027,0.907873852574703,-5.54601017046811,0.452391689016016,"FKBP9","FK506 binding protein 9",TRUE
+"219187_at",0.755049574909504,0.248913625463549,1.18411950398902,-5.27889653179387,0.37610794466641,"FKBPL","FK506 binding protein like",TRUE
+"219853_at",0.879755170997221,0.534482441975577,0.63102132935135,-5.74757983436839,0.566459265787426,"FKRP","fukutin related protein",TRUE
+"227882_at",0.986342822130003,0.935055846744629,0.0824161114930412,-5.93637568706805,0.0268500590674918,"FKRP","fukutin related protein",TRUE
+"223896_at",0.833285547058304,0.410688986368211,-0.838529229191968,-5.60289691970045,-0.390330456165359,"FKSG29","FKSG29",TRUE
+"224288_x_at",0.91671872326659,0.648069531461757,-0.462731097824604,-5.83592818991939,-0.137898843286351,"FKSG49","FKSG49",TRUE
+"211454_x_at",0.932463081848018,0.702066063669724,-0.387523879912897,-5.86680241895599,-0.112457439061121,"FKSG49","FKSG49",TRUE
+"208120_x_at",0.936318756756998,0.715979694078778,-0.368524829271986,-5.87375078653494,-0.110436808777553,"FKSG49","FKSG49",TRUE
+"224284_x_at",0.970540753946729,0.859820769271112,-0.178669622010918,-5.92414699566253,-0.0560573365826276,"FKSG49","FKSG49",TRUE
+"205283_at",0.979794616772313,0.903576933082532,0.122538896695345,-5.93237249276,0.03811749113272,"FKTN","fukutin",TRUE
+"212541_at",0.710883166549249,0.184638463688011,-1.36926074658955,-5.06556327063065,-0.564086681221722,"FLAD1","flavin adenine dinucleotide synthetase 1",TRUE
+"205661_s_at",0.735742230654287,0.220895296088727,-1.25967273059953,-5.19503318899977,-0.38775042219708,"FLAD1","flavin adenine dinucleotide synthetase 1",TRUE
+"215645_at",0.635626505801859,0.1065947043576,1.68208325749215,-4.64821825368455,0.770518210974094,"FLCN","folliculin",TRUE
+"1552664_at",0.725225714005638,0.20395942766698,1.30896745152018,-5.13792443565999,0.453549136292676,"FLCN","folliculin",TRUE
+"243062_at",0.744690501789823,0.236135331129952,1.21773336239302,-5.24213940350247,0.852682884712164,"FLCN","folliculin",TRUE
+"235250_at",0.999914081132133,0.999822639515202,0.000224809873659251,-5.93968345613319,0.000150450251556578,"FLCN","folliculin",TRUE
+"215704_at",0.477709967865451,0.0265700230869471,-2.37590387067432,-3.51062417557356,-1.72123016963997,"FLG","filaggrin",TRUE
+"1570423_at",0.79705794499562,0.330135090721299,0.995723853736478,-5.46798097362814,0.698523165049562,"FLG-AS1","FLG antisense RNA 1",TRUE
+"241014_at",0.8017109011727,0.339087914673647,0.977059186270693,-5.48510970534344,0.931866376285858,"FLG-AS1","FLG antisense RNA 1",TRUE
+"1569410_at",0.552281323843226,0.0494880413222871,-2.07809908892451,-4.03025970443647,-1.33550298374653,"FLG2","filaggrin family member 2",TRUE
+"204236_at",0.411110107932987,0.0162865019439021,2.60011676586539,-3.09393302074297,2.32252929879663,"FLI1","Fli-1 proto-oncogene, ETS transcription factor",TRUE
+"234520_at",0.468735421183467,0.0249042897592185,2.40601247522918,-3.45584138473646,1.2282820146995,"FLI1","Fli-1 proto-oncogene, ETS transcription factor",TRUE
+"210786_s_at",0.597654932724127,0.0736642189770459,1.87759175742774,-4.35460183630117,1.52410550809972,"FLI1","Fli-1 proto-oncogene, ETS transcription factor",TRUE
+"211825_s_at",0.627053909308516,0.0977236024822987,1.72897974803105,-4.57995632691678,1.03708909286168,"FLI1","Fli-1 proto-oncogene, ETS transcription factor",TRUE
+"234614_at",0.673582826047901,0.139850169666512,-1.53129692501817,-4.85788568622016,-0.835420032984551,"FLI1","Fli-1 proto-oncogene, ETS transcription factor",TRUE
+"237722_at",0.94370161759716,0.748091733148534,-0.325185042776531,-5.88830967535506,-0.229527421738924,"FLI1","Fli-1 proto-oncogene, ETS transcription factor",TRUE
+"212024_x_at",0.635368778245437,0.106412191588457,1.68301411063097,-4.64687706475568,0.76669211561161,"FLII","FLII, actin remodeling protein",TRUE
+"222065_s_at",0.652992478303356,0.12231558194172,1.60653381545191,-4.75517731268831,0.775614087282218,"FLII","FLII, actin remodeling protein",TRUE
+"212025_s_at",0.701272636707853,0.172961344417108,1.40815899548093,-5.01744118675062,0.622326954775566,"FLII","FLII, actin remodeling protein",TRUE
+"236164_at",0.181358093561736,0.00168836341331364,-3.57201924027677,-1.11813775362318,-1.32228595040811,"FLJ10038","uncharacterized protein FLJ10038",TRUE
+"205510_s_at",0.348854934125219,0.00914205629411586,-2.8561587475612,-2.59614823803683,-1.31298490735386,"FLJ10038","uncharacterized protein FLJ10038",TRUE
+"205511_at",0.806221445484273,0.346776355893709,0.961298483040986,-5.49934324066229,0.398823616527519,"FLJ10038","uncharacterized protein FLJ10038",TRUE
+"220529_at",0.830635993561085,0.403407352796613,0.851856763434693,-5.5922900102168,0.459637727680345,"FLJ11710","uncharacterized protein FLJ11710",TRUE
+"233210_at",0.828049584551678,0.39772013046455,-0.862373499728919,-5.58381009588416,-0.384760828899434,"FLJ12120","uncharacterized LOC388439",TRUE
+"233008_at",0.641326159307468,0.111784075082651,1.65616419856397,-4.68533658114219,0.574176827600353,"FLJ12825","uncharacterized LOC440101",TRUE
+"1557296_at",0.776954388941225,0.295479515665609,1.07149621463216,-5.39543990079729,0.849621891013786,"FLJ12825","uncharacterized LOC440101",TRUE
+"220211_at",0.948429371744093,0.765639461147932,0.301772897699732,-5.89542523854563,0.173941640004012,"FLJ13224","uncharacterized LOC79857",TRUE
+"1559011_at",0.773234064853267,0.284200639496921,1.09751595340988,-5.3694310638954,0.716350738862553,"FLJ13773","uncharacterized LOC246318",TRUE
+"243077_at",0.65284137151906,0.121658977958993,-1.60952126735066,-4.75101971576714,-0.619619657185383,"FLJ16734","uncharacterized LOC641928",TRUE
+"239509_at",0.997263441064271,0.985990072705931,0.017758989470991,-5.93952987111506,0.0138024687864657,"FLJ16779","uncharacterized LOC100192386",TRUE
+"228832_at",0.919485127002411,0.658202616414942,-0.448422833059045,-5.84221510188923,-0.208750697436582,"FLJ20021","uncharacterized LOC90024",TRUE
+"220678_at",0.915939421175188,0.645276508865088,0.466692115608692,-5.83415356926714,0.183461720489287,"FLJ20712","uncharacterized FLJ20712",TRUE
+"220401_at",0.870517518639056,0.50951013033765,0.670433086122584,-5.7230978240735,0.397725965011906,"FLJ21369","uncharacterized protein FLJ21369",TRUE
+"234216_at",0.720654489001931,0.19674246813238,1.33094281406439,-5.1118676874504,0.392118049973822,"FLJ21408","uncharacterized LOC400512",TRUE
+"234627_at",0.787929163003677,0.31396112931318,-1.0303531820359,-5.43542342685106,-0.543026683853753,"FLJ21408","uncharacterized LOC400512",TRUE
+"233604_at",0.631299908494113,0.10238548071138,-1.70390376785668,-4.61663182066048,-1.47816828103038,"FLJ22763","uncharacterized LOC401081",TRUE
+"216798_at",0.843095426822889,0.437305739710597,0.791042016029595,-5.63941598407438,0.306052558977464,"FLJ23519///RNH1","uncharacterized protein FLJ23519///ribonuclease/angiogenin inhibitor 1",TRUE
+"226706_at",0.535243600695458,0.0426850754705608,2.15046275981245,-3.90792396276169,1.4828987474512,"FLJ23867///QSOX1","uncharacterized protein FLJ23867///quiescin sulfhydryl oxidase 1",TRUE
+"1554286_at",0.796378050779806,0.328946584980938,0.998227791836903,-5.46566067651105,0.602951295939516,"FLJ25758","microtubule affinity regulating kinase 1 pseudogene",TRUE
+"237298_at",0.544577979658206,0.0467136849491904,2.10645876654633,-3.982634171291,1.58803892943335,"FLJ26850","FLJ26850 protein",TRUE
+"231313_at",0.947778780715578,0.761676491823761,0.307044782192092,-5.89386890620111,0.215803595697752,"FLJ27354","uncharacterized LOC400761",TRUE
+"239821_at",0.627092759817312,0.0985426842755529,1.72450114867931,-4.5865359467206,0.520300267851131,"FLJ30064","uncharacterized LOC644975",TRUE
+"222676_at",0.979124488698146,0.89867525905682,0.128803399777127,-5.9316061787353,0.0444674391562483,"FLJ30064///BRI3","uncharacterized LOC644975///brain protein I3",TRUE
+"1553258_at",0.868361060481977,0.502919694104368,0.681012094503084,-5.71628445943022,0.448228390811727,"FLJ30679","uncharacterized protein FLJ30679",TRUE
+"1552388_at",0.461822652528876,0.0232242807005189,2.43832832692613,-3.39662110035201,0.916820823414868,"FLJ30901///SCUBE1","uncharacterized protein FLJ30901///signal peptide, CUB domain and EGF like domain containing 1",TRUE
+"1557466_at",0.658906344891819,0.127049797136151,1.58538100973348,-4.78444348324241,0.44951502812745,"FLJ31104","uncharacterized LOC441072",TRUE
+"1560932_at",0.594972224548427,0.0717503554173314,1.89115337859807,-4.33337748404338,1.58971190665926,"FLJ31356","uncharacterized protein FLJ31356",TRUE
+"1553429_at",0.711036775119501,0.184811039985793,1.36870069185532,-5.06624795650963,0.793397466668724,"FLJ31713","uncharacterized protein FLJ31713",TRUE
+"1556578_a_at",0.988139605576153,0.943361785560451,0.0718552469931335,-5.9371690006969,0.0333516245319956,"FLJ31945","uncharacterized LOC440137",TRUE
+"235933_at",0.779079398289844,0.300175337985804,1.06087308303389,-5.40589817295411,0.245000634916815,"FLJ32154","uncharacterized protein FLJ32154",TRUE
+"235291_s_at",0.64030781048631,0.110938654840483,1.6603165231334,-4.67941959133083,1.40667250442959,"FLJ32255","uncharacterized LOC643977",TRUE
+"235292_at",0.785630329492068,0.31114840703834,1.03650210554726,-5.42953729549348,0.964959104912356,"FLJ32255","uncharacterized LOC643977",TRUE
+"1553467_at",0.776576421726155,0.293959068221453,1.07496170762075,-5.39200802201948,0.617329075631787,"FLJ32742///DCAF8L2","uncharacterized locus FLJ32742///DDB1 and CUL4 associated factor 8 like 2",TRUE
+"1563969_at",0.908801761853008,0.621096343862093,0.501311510805001,-5.81801384239755,0.17016288087509,"FLJ33360","FLJ33360 protein",TRUE
+"1564233_at",0.92070400963176,0.662566763724425,0.442289853691637,-5.84485058210195,0.196384367233715,"FLJ33534","uncharacterized LOC285150",TRUE
+"1553448_at",0.940044918888428,0.731357424396238,0.347685800416919,-5.88097555850767,0.163998871223683,"FLJ34503","uncharacterized FLJ34503",TRUE
+"1559277_at",0.95915232180739,0.814816316814865,-0.237023504441746,-5.91235718990553,-0.206978468886939,"FLJ35700","uncharacterized protein FLJ35700",TRUE
+"1564152_at",0.683019114815084,0.151739158166699,-1.4845973783456,-4.91966717952362,-0.520460324878564,"FLJ35816","FLJ35816 protein",TRUE
+"1557895_at",0.851319596585235,0.455223920243684,-0.760071761645393,-5.66215314107982,-0.386719311288922,"FLJ35934","FLJ35934",TRUE
+"1564383_s_at",0.87579870142401,0.523453231848746,-0.648300313965198,-5.73702162420511,-0.568301569961793,"FLJ35934","FLJ35934",TRUE
+"231527_at",0.567651250567208,0.0576030985560548,2.00262855149084,-4.15493908384079,0.542564188099484,"FLJ36840","uncharacterized LOC645524",TRUE
+"1565805_at",0.402463840838386,0.0147693344007804,2.64405400699447,-3.01005326777277,1.53973165379704,"FLJ37035","uncharacterized LOC399821",TRUE
+"1565806_at",0.722937902375896,0.19964963708305,1.32201614403565,-5.12249639041755,1.14862942300461,"FLJ37035","uncharacterized LOC399821",TRUE
+"239483_at",0.739007386198624,0.225669269683991,-1.24630422919492,-5.21019764449893,-1.05656234288074,"FLJ37035","uncharacterized LOC399821",TRUE
+"1560714_at",0.993892931327222,0.971351616971303,0.0363210514234946,-5.93904095834917,0.0304039583710223,"FLJ37035","uncharacterized LOC399821",TRUE
+"1560654_at",0.778686132916778,0.299615625768937,1.06213303907219,-5.40466264922828,0.991039536355909,"FLJ37201","tigger transposable element derived 2 pseudogene",TRUE
+"227596_at",0.758722841981575,0.25594346867831,1.1661750400125,-5.29815151611366,0.841259937641225,"FLJ37453","uncharacterized LOC729614",TRUE
+"227593_at",0.816800680706682,0.368650962334799,-0.917713875475569,-5.5375992466998,-0.402740064106684,"FLJ37453","uncharacterized LOC729614",TRUE
+"227664_at",0.83949628091616,0.42604267831659,-0.810909828485807,-5.62437997050836,-0.651984758992573,"FLJ37453","uncharacterized LOC729614",TRUE
+"1558579_at",0.791211889207316,0.321557538083637,1.01393759997468,-5.45098248581753,0.74050100545783,"FLJ37786","uncharacterized LOC642691",TRUE
+"1559441_s_at",0.973615804712521,0.873087863559705,-0.161596834443127,-5.92697253775037,-0.0519643542301553,"FLJ38576","uncharacterized LOC651430",TRUE
+"1559614_at",0.567292616148537,0.057457726357035,2.00389472243054,-4.15287256431916,1.49850266771699,"FLJ38773","uncharacterized protein FLJ38773",TRUE
+"1553464_at",0.801892820429336,0.339525430744025,0.976155791773327,-5.4859312686446,0.346802952071572,"FLJ40288","uncharacterized FLJ40288",TRUE
+"237659_at",0.9330573785522,0.704375922036958,0.384359890523651,-5.86798345733355,0.109948545805979,"FLJ40288","uncharacterized FLJ40288",TRUE
+"232955_at",0.822010986888098,0.385576809868522,0.885158353814426,-5.56510646298314,0.432734335062223,"FLJ41170","uncharacterized LOC440200",TRUE
+"244395_at",0.947326616179611,0.760371213265274,0.308783115285634,-5.89334987085041,0.282263646832431,"FLJ41455","uncharacterized LOC441441",TRUE
+"232050_at",0.888179187490412,0.553635754711673,-0.60146394172823,-5.76500362889007,-0.502627077563541,"FLJ42627","uncharacterized LOC645644",TRUE
+"220352_x_at",0.937462538530338,0.722678082766959,-0.359427657611563,-5.87695579288585,-0.120084054771995,"FLJ42627","uncharacterized LOC645644",TRUE
+"221944_at",0.970274748961658,0.858775229112987,-0.18001732295658,-5.92391191249683,-0.149395762237212,"FLJ42627","uncharacterized LOC645644",TRUE
+"1565786_x_at",0.76204760318585,0.261416823874784,1.15245555359743,-5.31269913414242,0.474805954874733,"FLJ45482","uncharacterized LOC645566",TRUE
+"239400_at",0.717615690889223,0.193398577142253,1.34133906154189,-5.09941342381863,1.02725026623598,"FLJ45513","uncharacterized LOC729220",TRUE
+"1553094_at",0.954429420677162,0.790609142625348,0.268749332212394,-5.90456585940205,0.141872180785514,"FLJ45513///TAC4","uncharacterized LOC729220///tachykinin 4 (hemokinin)",TRUE
+"230203_at",0.670970797333726,0.136891846661948,-1.54342136305503,-4.84159657720893,-0.615156949986613,"FLJ46875","uncharacterized LOC440918",TRUE
+"244237_at",0.874623344533688,0.52115873692845,-0.651919911498346,-5.73477518976706,-0.389083984148963,"FLJ90680","FLJ90680 protein",TRUE
+"214752_x_at",0.912421110187259,0.633205822808537,0.483899062806807,-5.82627268280055,0.24687030327798,"FLNA","filamin A",TRUE
+"200859_x_at",0.919156359329732,0.655675700408532,0.451981920374431,-5.84066935960038,0.268534292069932,"FLNA","filamin A",TRUE
+"213746_s_at",0.945432830098469,0.753247148936557,0.318288036083718,-5.89046054434573,0.194254885051864,"FLNA","filamin A",TRUE
+"208613_s_at",0.739189560382301,0.226364951383734,1.24437420106039,-5.21237547646241,0.657267472052817,"FLNB","filamin B",TRUE
+"208614_s_at",0.860085676417428,0.479384138953884,0.719450007709646,-5.6906720404157,0.483061058817988,"FLNB","filamin B",TRUE
+"207876_s_at",0.571677937624457,0.0596586833482286,1.98502177997937,-4.18358424133756,1.44025532299483,"FLNC","filamin C",TRUE
+"210142_x_at",0.789406360796076,0.316083543729123,1.02573894474937,-5.43981970932247,0.344618157215956,"FLOT1","flotillin 1",TRUE
+"208749_x_at",0.805335305758344,0.344635890235208,0.965662106681615,-5.49542360003171,0.306196755350198,"FLOT1","flotillin 1",TRUE
+"213819_s_at",0.940044918888428,0.731623961615976,0.347326011115003,-5.88109664740179,0.252131868727256,"FLOT1","flotillin 1",TRUE
+"208748_s_at",0.994536266629158,0.974819824394796,0.0319223127127095,-5.93918715902378,0.0136259558500509,"FLOT1","flotillin 1",TRUE
+"211299_s_at",0.940069411747533,0.731737396024604,-0.347172904139987,-5.88114813873547,-0.128876460833931,"FLOT2","flotillin 2",TRUE
+"201350_at",0.995025131654789,0.976787376545318,-0.0294271525963243,-5.93926171367266,-0.0114087504530307,"FLOT2","flotillin 2",TRUE
+"210414_at",0.984441970220849,0.92417809689064,0.0962617252831112,-5.93517120563877,0.03721781887704,"FLRT1","fibronectin leucine rich transmembrane protein 1",TRUE
+"219250_s_at",0.939389447806415,0.728602976151321,0.3514066852777,-5.87971600953438,0.413093584147736,"FLRT3","fibronectin leucine rich transmembrane protein 3",TRUE
+"222853_at",0.99659046136788,0.983001037204443,0.0215484511297769,-5.93945732245774,0.0231543616792838,"FLRT3","fibronectin leucine rich transmembrane protein 3",TRUE
+"232809_s_at",0.398934416346185,0.0140675913070955,2.66583228189124,-2.96822709284855,0.802006180152643,"FLT1","fms related tyrosine kinase 1",TRUE
+"226498_at",0.610486790071853,0.0831975922911031,1.81429496192849,-4.45222641878008,0.658907204160943,"FLT1","fms related tyrosine kinase 1",TRUE
+"226497_s_at",0.819018525257656,0.373341619255123,0.908594632944355,-5.54539691127039,0.422789179640896,"FLT1","fms related tyrosine kinase 1",TRUE
+"204406_at",0.899227984637696,0.589567911573983,0.54741192137145,-5.79477481244745,0.328820634418641,"FLT1","fms related tyrosine kinase 1",TRUE
+"210287_s_at",0.914242258486146,0.639554886466572,0.47483023450116,-5.83046105436146,0.37784081362485,"FLT1","fms related tyrosine kinase 1",TRUE
+"222033_s_at",0.982243328340126,0.914363438368985,0.108770684738125,-5.93392264915144,0.0694097889810985,"FLT1","fms related tyrosine kinase 1",TRUE
+"206674_at",0.830635993561085,0.403775430596047,-0.851179404509621,-5.59283285887075,-0.608661144571189,"FLT3","fms related tyrosine kinase 3",TRUE
+"206980_s_at",0.668518995965071,0.134766762449682,1.55226482955068,-4.82965133768096,0.822455038428514,"FLT3LG","fms related tyrosine kinase 3 ligand",TRUE
+"210607_at",0.897024165042344,0.582843229392829,0.557398399736476,-5.78947893138303,0.469186687747015,"FLT3LG","fms related tyrosine kinase 3 ligand",TRUE
+"229902_at",0.900692252557887,0.595942008533715,0.537997784752758,-5.79968199212626,0.436158442315167,"FLT4","fms related tyrosine kinase 4",TRUE
+"234379_at",0.950931310281113,0.776044369510661,0.28797240908749,-5.89937277806739,0.210719487111091,"FLT4","fms related tyrosine kinase 4",TRUE
+"210316_at",0.975398143273847,0.881150266900274,0.151246013038385,-5.92854787606423,0.0733227422895597,"FLT4","fms related tyrosine kinase 4",TRUE
+"228191_at",0.566644160327613,0.057074358016406,-2.00724750521203,-4.14739626534536,-0.906984202448136,"FLVCR1","feline leukemia virus subgroup C cellular receptor 1",TRUE
+"222906_at",0.64030781048631,0.110969260061208,-1.6601657392344,-4.6796346533548,-0.801876623652303,"FLVCR1","feline leukemia virus subgroup C cellular receptor 1",TRUE
+"235126_at",0.823074246722209,0.389311053496335,-0.878102689945019,-5.57094671431771,-0.468036767927807,"FLVCR1-AS1","FLVCR1 antisense RNA 1 (head to head)",TRUE
+"219316_s_at",0.870947480802804,0.510908066790825,-0.668198995655394,-5.72452362121229,-0.593811570109073,"FLVCR2","feline leukemia virus subgroup C cellular receptor family member 2",TRUE
+"1569536_at",0.946941640414848,0.759158707679798,0.310398766249665,-5.89286486298984,0.201309511807573,"FLVCR2","feline leukemia virus subgroup C cellular receptor family member 2",TRUE
+"222866_s_at",0.964843159353411,0.83720686961062,0.207899081338447,-5.9186535241613,0.0672316694642436,"FLVCR2","feline leukemia virus subgroup C cellular receptor family member 2",TRUE
+"223950_s_at",0.753173067319196,0.246429135825754,-1.19055189116608,-5.27193189917227,-0.440739998050789,"FLYWCH1","FLYWCH-type zinc finger 1",TRUE
+"225952_at",0.93178677872825,0.698843517774864,0.39194479363758,-5.86513622117664,0.270624868134404,"FLYWCH1","FLYWCH-type zinc finger 1",TRUE
+"234106_s_at",0.943464796017993,0.747188256618506,-0.326395378801485,-5.88792751779786,-0.0737037483165022,"FLYWCH1","FLYWCH-type zinc finger 1",TRUE
+"226079_at",0.632216562924782,0.103368122506644,-1.69874256768388,-4.62413062340493,-0.81905904374218,"FLYWCH2","FLYWCH family member 2",TRUE
+"226780_s_at",0.238716647597999,0.00313486150846572,-3.31392024642119,-1.6621323449375,-1.28965389834788,"FMC1","formation of mitochondrial complex V assembly factor 1 homolog",TRUE
+"1563559_at",0.0328648147850145,3.36612643431333e-05,-5.17667010982553,2.32476931574347,-2.82166302279723,"FMN1","formin 1",TRUE
+"1570156_s_at",0.948951323154927,0.767474687857114,0.299334483867071,-5.89613605491337,0.0991766201903026,"FMN1","formin 1",TRUE
+"238621_at",0.969165731345074,0.853945855736235,-0.186246855686079,-5.92280239681266,-0.143132259535233,"FMN1","formin 1",TRUE
+"230946_at",0.702888118552354,0.174767874430242,1.40200713374317,-5.02512599791287,0.731484529017833,"FMN2","formin 2",TRUE
+"1555471_a_at",0.864894115958506,0.493791400244209,0.695795225960277,-5.70659270919104,0.644684547459478,"FMN2","formin 2",TRUE
+"1559244_at",0.934776835502861,0.710293619222064,-0.376272072533833,-5.87095904271571,-0.35141513253774,"FMN2","formin 2",TRUE
+"223618_at",0.984161165881616,0.922841058289136,0.0979648340974311,-5.93501016374148,0.125575393139568,"FMN2","formin 2",TRUE
+"204789_at",0.528235927681883,0.0408593874196936,2.17165204410417,-3.87160304858093,2.06322947686931,"FMNL1","formin like 1",TRUE
+"1569257_at",0.547195868806649,0.0476341090965408,2.09688632380541,-3.99875595783105,1.23245096499761,"FMNL1","formin like 1",TRUE
+"242665_at",0.457531863501901,0.0227823797390845,2.44718825935651,-3.38030998784955,1.76651527609761,"FMNL2","formin like 2",TRUE
+"226184_at",0.470726957161354,0.0253637241115199,2.39752653892127,-3.47132030989116,2.09585940625683,"FMNL2","formin like 2",TRUE
+"235881_at",0.783717017171002,0.306305421855092,1.04718193839107,-5.41923895696894,0.698238087051904,"FMNL2","formin like 2",TRUE
+"230640_at",0.762729892034689,0.2622893006921,1.15028829516322,-5.31498338246045,0.949931359299801,"FMNL3","formin like 3",TRUE
+"232249_at",0.782257848574678,0.304316300156201,-1.0516030136111,-5.41494802889924,-0.704448199320977,"FMNL3","formin like 3",TRUE
+"227844_at",0.796378050779806,0.328670659956522,0.998810005204645,-5.46512040505028,0.605918827875347,"FMNL3","formin like 3",TRUE
+"238823_at",0.90344422113846,0.604094679492624,-0.526027949030144,-5.80580176675348,-0.226243277495507,"FMNL3","formin like 3",TRUE
+"205666_at",0.967098812766994,0.846554375384501,0.195796032056316,-5.92102861747758,0.183283731756247,"FMO1","flavin containing monooxygenase 1",TRUE
+"228268_at",0.778397054392363,0.298317407123542,1.06506190540395,-5.40178550028571,0.357803599874449,"FMO2","flavin containing monooxygenase 2",TRUE
+"211726_s_at",0.83629640285155,0.417587521771029,0.82604059365889,-5.61269431009383,0.400424114881411,"FMO2","flavin containing monooxygenase 2",TRUE
+"40665_at",0.766086095192912,0.266480462815298,1.13995080965409,-5.3258268186858,1.29614538439651,"FMO3","flavin containing monooxygenase 3",TRUE
+"206496_at",0.877857073443889,0.529122631099101,0.639393840383313,-5.74249810292106,0.740601155890447,"FMO3","flavin containing monooxygenase 3",TRUE
+"206263_at",0.929088231432081,0.687850273934507,-0.407086744106963,-5.85928832073678,-0.146700244144133,"FMO4","flavin containing monooxygenase 4",TRUE
+"215300_s_at",0.791211889207316,0.321574793344903,-1.01390062236753,-5.45101727895655,-0.914731807418194,"FMO5","flavin containing monooxygenase 5",TRUE
+"205776_at",0.955743694751825,0.798128600095819,-0.258865707367567,-5.90709727540875,-0.196087619320447,"FMO5","flavin containing monooxygenase 5",TRUE
+"1569688_at",0.966593471043185,0.844807950800161,0.198054956467209,-5.92059609590273,0.120141227164097,"FMO5","flavin containing monooxygenase 5",TRUE
+"215174_at",0.969882914559333,0.857198726243525,0.182050080861472,-5.92355400172541,0.104584897851367,"FMO6P","flavin containing monooxygenase 6 pseudogene",TRUE
+"1553924_at",0.94895689004559,0.769103677138671,-0.297171643297643,-5.89676175482851,-0.247280204439031,"FMO9P","flavin containing monooxygenase 9 pseudogene",TRUE
+"202709_at",0.832830355420594,0.409962893006836,-0.839851405330035,-5.60185162374425,-0.779158096306053,"FMOD","fibromodulin",TRUE
+"215245_x_at",0.789661545166663,0.317388113209879,1.0229135250219,-5.44250287450223,0.304043364128455,"FMR1","fragile X mental retardation 1",TRUE
+"203689_s_at",0.820288124919738,0.378427238871336,0.898792778824307,-5.55369806979919,0.285622249306654,"FMR1","fragile X mental retardation 1",TRUE
+"1552906_at",0.929786324276714,0.690119630146955,0.403953139079966,-5.86051644224074,0.543339193945328,"FMR1NB","fragile X mental retardation 1 neighbor",TRUE
+"1558199_at",0.593339168375633,0.0701672496547474,1.90261265085023,-4.31536004282419,0.760891124520027,"FN1","fibronectin 1",TRUE
+"214702_at",0.68529926526524,0.153891627770985,1.47646418087535,-4.93026983170164,1.81866325282024,"FN1","fibronectin 1",TRUE
+"214701_s_at",0.768852835478002,0.272439865723749,1.12545578347879,-5.34088585172896,1.22727782328988,"FN1","fibronectin 1",TRUE
+"210495_x_at",0.787784580458053,0.313622117281654,1.03109223989745,-5.43471762453882,1.62123924082215,"FN1","fibronectin 1",TRUE
+"211719_x_at",0.788413816943444,0.314659274019669,1.02883296807359,-5.43687379994805,1.97838032920192,"FN1","fibronectin 1",TRUE
+"212464_s_at",0.791646964605038,0.322261342441515,1.01243048623045,-5.45239963558683,1.87555436904292,"FN1","fibronectin 1",TRUE
+"216442_x_at",0.803487298448767,0.341509304849062,0.972069414247046,-5.48963883594545,1.53285996125632,"FN1","fibronectin 1",TRUE
+"219744_at",0.801527706887973,0.338276211000274,-0.978737332611031,-5.4835817302405,-0.574161193815557,"FN3K","fructosamine 3 kinase",TRUE
+"218210_at",0.996625121774816,0.983216586477016,0.0212751703299246,-5.93946302236999,0.00663729521551026,"FN3KRP","fructosamine 3 kinase related protein",TRUE
+"230086_at",0.751439449221893,0.244307111395051,1.1960844164853,-5.26591530176874,0.985694294574434,"FNBP1","formin binding protein 1",TRUE
+"213940_s_at",0.7974001826642,0.33073408554884,-0.994464258222808,-5.46914618831186,-0.491797298257007,"FNBP1","formin binding protein 1",TRUE
+"230389_at",0.839519981963042,0.428053615988849,-0.80733888445958,-5.62710829547738,-0.605454198692359,"FNBP1","formin binding protein 1",TRUE
+"212288_at",0.886023097762234,0.548353871406122,-0.609560049192421,-5.76031119471975,-0.471580039871908,"FNBP1","formin binding protein 1",TRUE
+"215017_s_at",0.801285128907773,0.337955338582591,-0.979401478214917,-5.48297635666215,-0.483371374088406,"FNBP1L","formin binding protein 1 like",TRUE
+"235101_at",0.682744111897512,0.15074690295065,1.48837829938932,-4.91472229189958,0.493945775284206,"FNBP4","formin binding protein 4",TRUE
+"242472_x_at",0.708894565317004,0.180863104164917,1.38161773341667,-5.05039719491198,0.537232390005534,"FNBP4","formin binding protein 4",TRUE
+"229272_at",0.839425347843955,0.425308853617222,-0.81221554149585,-5.62337953947448,-0.384483715415279,"FNBP4","formin binding protein 4",TRUE
+"212232_at",0.928295253101366,0.685385729267301,-0.410494576793323,-5.85794212341324,-0.121745527364007,"FNBP4","formin binding protein 4",TRUE
+"226930_at",0.986342822130003,0.935276140557235,0.0821358929550001,-5.93639813847778,0.0939764364318845,"FNDC1","fibronectin type III domain containing 1",TRUE
+"227185_at",0.740476003158683,0.22975421264485,-1.23503549884306,-5.22287217301423,-0.80815629051394,"FNDC10","fibronectin type III domain containing 10",TRUE
+"220426_at",0.89767014756104,0.584725232692456,-0.554597798359368,-5.79097348297357,-0.511693470829024,"FNDC11","fibronectin type III domain containing 11",TRUE
+"215910_s_at",0.308621629697291,0.00624560020493321,3.02120325241301,-2.26500722302509,1.0194094006787,"FNDC3A","fibronectin type III domain containing 3A",TRUE
+"202304_at",0.362147920783916,0.0104454919264058,2.79774895392017,-2.71153044923962,1.169763447985,"FNDC3A","fibronectin type III domain containing 3A",TRUE
+"241611_s_at",0.623503825356688,0.0943291388895563,1.74788897234083,-4.55203672241502,1.38791284619449,"FNDC3A","fibronectin type III domain containing 3A",TRUE
+"238961_s_at",0.821745015752602,0.38451980138879,0.88716360728585,-5.56343872859502,0.684981322213708,"FNDC3A","fibronectin type III domain containing 3A",TRUE
+"1569490_at",0.975913043793143,0.884818640364531,0.146542078723215,-5.92922941374135,0.0606413163212718,"FNDC3B","fibronectin type III domain containing 3B",TRUE
+"218843_at",0.310311222562286,0.0065439202490044,3.00113250198905,-2.30565368306763,2.27396702237396,"FNDC4","fibronectin type III domain containing 4",TRUE
+"230646_at",0.673366993714442,0.139312062610017,1.53348650140191,-4.85495154382925,0.382458386234435,"FNDC5","fibronectin type III domain containing 5",TRUE
+"226097_at",0.751112081216662,0.244076909325091,1.19668676163262,-5.26525878878562,0.36558104678666,"FNDC5","fibronectin type III domain containing 5",TRUE
+"226096_at",0.962125056232529,0.827942455106176,-0.219925966662775,-5.91615290840807,-0.102075243933338,"FNDC5","fibronectin type III domain containing 5",TRUE
+"240837_at",0.963796115120365,0.834672995902136,-0.211185316314091,-5.91798415291415,-0.174516853588404,"FNDC7","fibronectin type III domain containing 7",TRUE
+"220499_at",0.986889306520757,0.939371507090765,0.0769276995217025,-5.9368015150016,0.0408974548117138,"FNDC8","fibronectin type III domain containing 8",TRUE
+"1554801_at",0.830635993561085,0.404020588674276,0.850728469065266,-5.593194024126,0.434806142592159,"FNDC9","fibronectin type III domain containing 9",TRUE
+"228768_at",0.603702127972549,0.0779996751747387,-1.84797352497262,-4.40057985277696,-0.435268057119641,"FNIP1","folliculin interacting protein 1",TRUE
+"1559060_a_at",0.772975577977561,0.283510520796378,1.09913202324964,-5.367797339956,0.446108142539908,"FNIP1","folliculin interacting protein 1",TRUE
+"228250_at",0.839508810008021,0.426110367710305,-0.810789457712551,-5.62447212198545,-0.387699322084396,"FNIP1","folliculin interacting protein 1",TRUE
+"243861_at",0.849935057946582,0.451979979675917,0.765623079658798,-5.65814063824707,0.619878868711479,"FNIP1","folliculin interacting protein 1",TRUE
+"223997_at",0.99691938672319,0.984364929309373,0.0198192891619552,-5.93949216210569,0.0131025926890738,"FNIP1","folliculin interacting protein 1",TRUE
+"1569352_at",0.705559553212919,0.177231801048405,-1.39369784937559,-5.03546172886681,-1.01337911103105,"FNIP2","folliculin interacting protein 2",TRUE
+"225922_at",0.854184492233394,0.464565085784777,-0.744217760636693,-5.67346026466878,-0.378104904036721,"FNIP2","folliculin interacting protein 2",TRUE
+"225924_at",0.906507435035949,0.614305303068913,-0.511145316579946,-5.81322370997243,-0.206900575898345,"FNIP2","folliculin interacting protein 2",TRUE
+"226460_at",0.932091525948902,0.700499582877955,-0.389671900256025,-5.86599517808157,-0.17461097583092,"FNIP2","folliculin interacting protein 2",TRUE
+"209471_s_at",0.915939421175188,0.645252063654609,-0.466726816779091,-5.83413795694747,-0.242363167900312,"FNTA","farnesyltransferase, CAAX box, alpha",TRUE
+"230808_at",0.937462538530338,0.722679762053982,-0.359425380852421,-5.87695658510551,-0.306710521205859,"FNTA","farnesyltransferase, CAAX box, alpha",TRUE
+"200090_at",0.980135507384952,0.906652299457743,-0.118611054634872,-5.93283351527853,-0.0562587303452169,"FNTA","farnesyltransferase, CAAX box, alpha",TRUE
+"1568865_at",0.913782990161554,0.638498176585472,-0.476336789678122,-5.82977063157097,-0.18666176780993,"FNTB","farnesyltransferase, CAAX box, beta",TRUE
+"232875_at",0.835952408568777,0.416573214773868,0.827868610276854,-5.61126881463229,0.663773312293347,"FOCAD","focadhesin",TRUE
+"218503_at",0.929553571318679,0.689714298696958,0.404512531973709,-5.86029789007583,0.358134881693601,"FOCAD","focadhesin",TRUE
+"217483_at",0.913187070374658,0.63576526445014,-0.480238316006064,-5.82797269914156,-0.310535147636117,"FOLH1","folate hydrolase (prostate-specific membrane antigen) 1",TRUE
+"211303_x_at",0.934784679606929,0.710460682726234,-0.376044117102986,-5.871042005364,-0.454804322816927,"FOLH1B","folate hydrolase 1B",TRUE
+"215363_x_at",0.818768038148976,0.372477684734878,0.91026850247574,-5.54397100542041,1.18652865952248,"FOLH1B///FOLH1","folate hydrolase 1B///folate hydrolase (prostate-specific membrane antigen) 1",TRUE
+"205860_x_at",0.957571530817866,0.809196137802407,0.244365944797673,-5.91064042530396,0.334201799700982,"FOLH1B///FOLH1","folate hydrolase 1B///folate hydrolase (prostate-specific membrane antigen) 1",TRUE
+"217487_x_at",0.988713664405312,0.945604481578363,-0.0690051823925259,-5.93736449094679,-0.0463977912963749,"FOLH1B///FOLH1","folate hydrolase 1B///folate hydrolase (prostate-specific membrane antigen) 1",TRUE
+"204437_s_at",0.849935057946582,0.452043237742216,0.765514597413563,-5.65821931377448,0.755795873903697,"FOLR1","folate receptor 1",TRUE
+"211074_at",0.91704539957792,0.648816958241842,0.461672385709849,-5.8364000062979,0.125999464024165,"FOLR1","folate receptor 1",TRUE
+"204829_s_at",0.816800680706682,0.368227746343601,-0.918540443203564,-5.53688891822761,-0.400512613489293,"FOLR2","folate receptor beta",TRUE
+"229619_at",0.961212424803935,0.823980672671874,-0.225079115167133,-5.915038645908,-0.148366341982896,"FOLR2","folate receptor beta",TRUE
+"206371_at",0.856287407895097,0.470155427252141,-0.734820406832847,-5.68005584078256,-0.549003323016934,"FOLR3","folate receptor 3",TRUE
+"225088_at",0.873301865850313,0.51815531872157,-0.656671127309259,-5.73180822121168,-0.185487846200248,"FOPNL","FGFR1OP N-terminal like",TRUE
+"225087_at",0.93076292027359,0.69316515020942,-0.399754231644809,-5.86214742968101,-0.0930453832249523,"FOPNL","FGFR1OP N-terminal like",TRUE
+"209189_at",0.866077812635028,0.496797281471861,-0.690910208030219,-5.70981729288252,-1.12006582812872,"FOS","Fos proto-oncogene, AP-1 transcription factor subunit",TRUE
+"202768_at",0.891653456393983,0.561527758037779,-0.589441909991146,-5.77185966579382,-0.543252346434768,"FOSB","FosB proto-oncogene, AP-1 transcription factor subunit",TRUE
+"204420_at",0.438039332500438,0.0200452566971394,2.5059116988413,-3.27140580773285,3.97412531161385,"FOSL1","FOS like 1, AP-1 transcription factor subunit",TRUE
+"218880_at",0.452757219662988,0.0218035621284435,2.46739529067391,-3.34299017181992,1.6911260545323,"FOSL2","FOS like 2, AP-1 transcription factor subunit",TRUE
+"205409_at",0.541849190341655,0.0452934671478226,2.12156712319723,-3.95709351716944,1.02808778048549,"FOSL2","FOS like 2, AP-1 transcription factor subunit",TRUE
+"218881_s_at",0.55074985379986,0.0489511840954559,2.08347360834164,-4.02126602365957,1.89259570553336,"FOSL2","FOS like 2, AP-1 transcription factor subunit",TRUE
+"225262_at",0.62110896023334,0.0912080587818781,1.76579675520515,-4.52538907563469,1.10001011581389,"FOSL2","FOS like 2, AP-1 transcription factor subunit",TRUE
+"228188_at",0.755685495730197,0.249871639244758,1.18165201027515,-5.28155946287977,0.751869540171807,"FOSL2","FOS like 2, AP-1 transcription factor subunit",TRUE
+"204667_at",0.66932922090261,0.135435530592879,-1.54946943912774,-4.833433016522,-2.27707280516583,"FOXA1","forkhead box A1",TRUE
+"237086_at",0.789661545166663,0.31715574765739,-1.02341618260035,-5.44202601363352,-1.69822631626218,"FOXA1","forkhead box A1",TRUE
+"214312_at",0.86679822545543,0.498073059830222,0.688841967301719,-5.7111759948615,0.420593138317303,"FOXA2","forkhead box A2",TRUE
+"210103_s_at",0.94895689004559,0.768033750346196,0.298592042029898,-5.89635134702307,0.248102919001089,"FOXA2","forkhead box A2",TRUE
+"40284_at",0.950037803488168,0.773171171711716,-0.291777438824011,-5.89830266887682,-0.278671991104311,"FOXA2","forkhead box A2",TRUE
+"228463_at",0.812302873476553,0.35748909012251,0.939729444674053,-5.51847889749321,0.934116218023599,"FOXA3","forkhead box A3",TRUE
+"208513_at",0.301965976738642,0.00578802640369632,3.0538544000577,-2.1986752649265,1.76457261784209,"FOXB1","forkhead box B1",TRUE
+"1553613_s_at",0.500388308784901,0.0318038793205996,2.29147621246373,-3.66214785528689,2.82413961874503,"FOXC1","forkhead box C1",TRUE
+"213260_at",0.521576878185249,0.0378912365825663,2.2080047686601,-3.80877808291609,1.87440561495462,"FOXC1","forkhead box C1",TRUE
+"239058_at",0.384664730952718,0.0125934529868887,2.7151315060092,-2.87295382671633,1.37887219994907,"FOXC2","forkhead box C2",TRUE
+"214520_at",0.647754107214051,0.119117774147556,1.62121192085147,-4.73469254041051,1.14253486333953,"FOXC2","forkhead box C2",TRUE
+"241787_at",0.862634144901168,0.485974255572217,0.708579662107756,-5.69805120514563,0.257571528244878,"FOXCUT","FOXC1 upstream transcript (non-protein coding)",TRUE
+"206307_s_at",0.856257656023992,0.469908136963605,0.735234698869948,-5.67976674355483,0.845317772350182,"FOXD1","forkhead box D1",TRUE
+"207653_at",0.720952283360079,0.196980683543874,-1.33020749171592,-5.11274548788922,-0.890707083986821,"FOXD2","forkhead box D2",TRUE
+"224456_s_at",0.965707350334601,0.839791995609964,-0.204548787649427,-5.91932518142295,-0.143614777151142,"FOXD2-AS1","FOXD2 antisense RNA 1 (head to head)",TRUE
+"224457_at",0.988438753637362,0.944852546539921,0.0699606905666479,-5.93729983227667,0.0566066359566424,"FOXD2-AS1","FOXD2 antisense RNA 1 (head to head)",TRUE
+"241612_at",0.740476003158683,0.229625650671363,-1.23538781649806,-5.22247740440566,-1.03580809469026,"FOXD3","forkhead box D3",TRUE
+"208500_x_at",0.937232018318296,0.721446823774949,-0.361097507298988,-5.87637341831309,-0.166033842367899,"FOXD3","forkhead box D3",TRUE
+"241609_at",0.964281073574005,0.83581608336069,0.209702529446907,-5.91828747511245,0.101949367424139,"FOXD3","forkhead box D3",TRUE
+"230423_at",0.565043084457947,0.0564037150953193,-2.01316110501299,-4.13772234096532,-1.73968372129516,"FOXD3-AS1","FOXD3 antisense RNA 1 (head to head)",TRUE
+"1567341_at",0.842048161961563,0.435216076979823,-0.794704016879178,-5.6366709332022,-0.381478015331046,"FOXD4","forkhead box D4",TRUE
+"217032_at",0.899061060612873,0.589242114484274,-0.547894442353026,-5.7945210668647,-0.286508162242828,"FOXD4L1///FOXD4","forkhead box D4-like 1///forkhead box D4",TRUE
+"206912_at",0.327864702134751,0.00767084348813277,2.93249896072845,-2.44387916319805,3.32651331248733,"FOXE1","forkhead box E1",TRUE
+"208239_at",0.878028110926725,0.529819907374385,-0.638302037838688,-5.74316442899802,-0.335455991524612,"FOXE1","forkhead box E1",TRUE
+"220621_at",0.945498722604777,0.753695877214464,0.317688468817696,-5.89064536569475,0.266680265833453,"FOXE3","forkhead box E3",TRUE
+"205935_at",0.989482241798092,0.948200508287193,0.0657068274466284,-5.93758085940258,0.0457600918464154,"FOXF1","forkhead box F1",TRUE
+"206377_at",0.500677386446044,0.0320140492549679,2.28835978299295,-3.66768025144141,2.65632082968397,"FOXF2","forkhead box F2",TRUE
+"206018_at",0.391240007651669,0.013148654190391,2.6959541983506,-2.91011108074192,3.01088485267188,"FOXG1","forkhead box G1",TRUE
+"207658_s_at",0.51531387545335,0.0357080706038712,2.23643342702271,-3.75920499352392,1.03808342808106,"FOXG1","forkhead box G1",TRUE
+"231407_s_at",0.940044918888428,0.731265232748649,-0.347810257596136,-5.88093364297371,-0.224264994607632,"FOXH1","forkhead box H1",TRUE
+"207644_at",0.979976490833035,0.904461206155185,0.1214093082087,-5.93250661222197,0.081226925427968,"FOXH1","forkhead box H1",TRUE
+"208006_at",0.782452900355118,0.304634492127102,1.05089441744833,-5.41563685844644,0.903334944413576,"FOXI1","forkhead box I1",TRUE
+"205906_at",0.25025917061226,0.00349699142839994,3.26791768118303,-1.75800334136971,2.56952896860964,"FOXJ1","forkhead box J1",TRUE
+"1555305_at",0.74371414757151,0.234507863984486,1.22211218789668,-5.237285452782,0.571710285152039,"FOXJ2","forkhead box J2",TRUE
+"203734_at",0.90998880119877,0.625349101975325,-0.49517875344694,-5.82095517816623,-0.206642553558767,"FOXJ2","forkhead box J2",TRUE
+"206015_s_at",0.752235383514782,0.245425122707158,-1.19316507620617,-5.26909309784541,-0.315604028237612,"FOXJ3","forkhead box J3",TRUE
+"217310_s_at",0.967307773762258,0.847073230909248,-0.195125116290807,-5.92115612721085,-0.0539959218489621,"FOXJ3","forkhead box J3",TRUE
+"226715_at",0.606941574497969,0.0807954077073736,1.82962538931959,-4.42880143175591,0.619176567359366,"FOXK1","forkhead box K1",TRUE
+"236011_at",0.774230543658252,0.288662561000086,-1.08713520382821,-5.37987418171259,-0.863976884900016,"FOXK1","forkhead box K1",TRUE
+"230342_at",0.954340987878543,0.789864442313303,-0.269729644906955,-5.90430964498913,-0.136156655495484,"FOXK1","forkhead box K1",TRUE
+"235519_at",0.995111934465262,0.977440149882515,-0.0285993782467974,-5.93928510776521,-0.0216050444528593,"FOXK1","forkhead box K1",TRUE
+"223409_at",0.609532363331105,0.0817635515850089,-1.82339991546948,-4.43833108531555,-0.708732876610688,"FOXK2","forkhead box K2",TRUE
+"226224_at",0.673582826047901,0.139794389852154,-1.53152357282171,-4.85758212125629,-0.603470401872302,"FOXK2","forkhead box K2",TRUE
+"223410_s_at",0.812302873476553,0.360614899078278,0.933518270136057,-5.52391545303161,0.318796506077417,"FOXK2","forkhead box K2",TRUE
+"223408_s_at",0.88113080359582,0.537710158101363,-0.626001203057979,-5.75059591140057,-0.507473111622103,"FOXK2","forkhead box K2",TRUE
+"242937_at",0.895690630367785,0.575776191811941,-0.567955425376598,-5.78377949243591,-0.179067917921998,"FOXK2","forkhead box K2",TRUE
+"203064_s_at",0.897222133890828,0.583346180439893,-0.556649519958758,-5.7898792895866,-0.187944200644923,"FOXK2","forkhead box K2",TRUE
+"242938_s_at",0.983781970605789,0.920714501266531,-0.100674238788073,-5.93474815406462,-0.0357668097203803,"FOXK2","forkhead box K2",TRUE
+"243409_at",0.580137756009815,0.0626353501491604,1.96045538254649,-4.22326652834341,1.83679467235159,"FOXL1","forkhead box L1",TRUE
+"216572_at",0.912246017248541,0.63229035335438,0.485210078233662,-5.82566079015928,0.174545992639428,"FOXL1","forkhead box L1",TRUE
+"220102_at",0.588467901034655,0.0671103780438005,1.92539671442236,-4.27931185103132,1.55761132607025,"FOXL2","forkhead box L2",TRUE
+"202580_x_at",0.959357995170594,0.815777165465269,0.235769554652557,-5.91264517372537,0.0767440939667097,"FOXM1","forkhead box M1",TRUE
+"1558687_a_at",0.606900628956089,0.0807260181153128,1.83007406698893,-4.42811371731579,1.06187343692129,"FOXN1","forkhead box N1",TRUE
+"207683_at",0.990810941805126,0.955087419278683,-0.056960251306214,-5.93810334247139,-0.0286497046060807,"FOXN1","forkhead box N1",TRUE
+"226711_at",0.734614760371776,0.219232645864437,1.26438055825687,-5.18965989254216,0.570203737117414,"FOXN2","forkhead box N2",TRUE
+"206708_at",0.787303934962758,0.3131648098321,1.03209007656155,-5.43376396362878,0.549929979468286,"FOXN2","forkhead box N2",TRUE
+"218031_s_at",0.309481421123565,0.00651510042456741,-3.00303270676808,-2.30180971782789,-1.73296299395759,"FOXN3","forkhead box N3",TRUE
+"222494_at",0.471777506776789,0.0257223364920276,-2.3910009872101,-3.48320276901618,-1.13394976621579,"FOXN3","forkhead box N3",TRUE
+"205022_s_at",0.560295667354693,0.0542474670810328,-2.03260797454119,-4.10577638264307,-1.09313047745317,"FOXN3","forkhead box N3",TRUE
+"230790_x_at",0.647754107214051,0.119058675413823,-1.62148627483379,-4.73430828099102,-0.83149790445978,"FOXN3","forkhead box N3",TRUE
+"205021_s_at",0.687770445187929,0.15710224215733,1.4645027286912,-4.94577754887964,0.49881834496345,"FOXN3","forkhead box N3",TRUE
+"229237_s_at",0.898275196327427,0.587431726468901,0.550578115165396,-5.79310582870924,0.415027930245786,"FOXN3","forkhead box N3",TRUE
+"241984_at",0.947969282616012,0.76323772918796,-0.304966837319177,-5.89448553341439,-0.142296306831793,"FOXN3","forkhead box N3",TRUE
+"229652_s_at",0.973071267819624,0.870559784039104,-0.164846150631324,-5.92645656453284,-0.134520450715707,"FOXN3","forkhead box N3",TRUE
+"227885_at",0.68075528846836,0.148714058810537,-1.49618807423855,-4.90447623861035,-0.769620698369802,"FOXN3-AS1","FOXN3 antisense RNA 1",TRUE
+"227887_at",0.812302873476553,0.36016027037513,-0.934419392578609,-5.52312876689678,-0.315140711102565,"FOXN3-AS1","FOXN3 antisense RNA 1",TRUE
+"220852_at",0.962555471240652,0.829460991585062,0.217952405213347,-5.91657284818312,0.146362166752223,"FOXN3-AS2","FOXN3 antisense RNA 2",TRUE
+"1562695_at",0.756952614607938,0.252594429876942,-1.1746774282868,-5.2890602252833,-0.721113500437502,"FOXN4","forkhead box N4",TRUE
+"241009_at",0.86395116513843,0.490361155357794,0.701390733803526,-5.70287250013534,0.457486604888116,"FOXN4","forkhead box N4",TRUE
+"1564713_a_at",0.957813759927439,0.810314586824276,0.242903673775902,-5.91098647741135,0.133380231274361,"FOXN4","forkhead box N4",TRUE
+"202723_s_at",0.52629147962869,0.0396923040152778,2.18565101576377,-3.84748598656993,2.50994782408709,"FOXO1","forkhead box O1",TRUE
+"202724_s_at",0.639705117673934,0.110205087890512,1.66394116012999,-4.67424532063944,1.85022345213878,"FOXO1","forkhead box O1",TRUE
+"228484_s_at",0.8376750578867,0.422334275566915,0.817522748129535,-5.61929764668234,0.555841525716662,"FOXO1","forkhead box O1",TRUE
+"224889_at",0.542397752248982,0.0455398170214496,2.11891615679748,-3.96158337786308,0.98819425778775,"FOXO3","forkhead box O3",TRUE
+"204131_s_at",0.622917527985155,0.093521483044289,1.75247374416916,-4.54523343215967,0.989666106057154,"FOXO3","forkhead box O3",TRUE
+"224891_at",0.648927539488968,0.119690244412028,1.61856022510761,-4.73840391010061,0.76949333278486,"FOXO3","forkhead box O3",TRUE
+"231548_at",0.746437759467951,0.238121271486047,1.21242082954257,-5.24800812123907,0.803600537394155,"FOXO3","forkhead box O3",TRUE
+"210655_s_at",0.528176582660474,0.0407020590612793,2.17351788809705,-3.86839416312797,1.37478393801315,"FOXO3B///FOXO3","forkhead box O3B pseudogene///forkhead box O3",TRUE
+"217399_s_at",0.552420073963858,0.0500081888099225,2.07294145602511,-4.03887629696874,1.3651278313327,"FOXO3B///FOXO3","forkhead box O3B pseudogene///forkhead box O3",TRUE
+"204132_s_at",0.561084367279569,0.0546486786785999,2.0289379960573,-4.11182074522853,1.01814092528365,"FOXO3B///FOXO3","forkhead box O3B pseudogene///forkhead box O3",TRUE
+"205451_at",0.668403802227594,0.134529748188354,-1.55325827744163,-4.82830607917149,-1.04633578136469,"FOXO4","forkhead box O4",TRUE
+"239657_x_at",0.635626505801859,0.106622604969671,-1.68194107752893,-4.64842305957591,-1.22142795755658,"FOXO6","forkhead box O6",TRUE
+"224837_at",0.792436690618566,0.323843706256866,-1.00905040153375,-5.4555710119473,-0.518567621914555,"FOXP1","forkhead box P1",TRUE
+"223936_s_at",0.813483421177339,0.364077536647636,-0.926679804014732,-5.52986273623702,-0.638434724893714,"FOXP1","forkhead box P1",TRUE
+"223937_at",0.862639573412331,0.486195305267977,-0.708216528422925,-5.6982958662051,-0.540760628842195,"FOXP1","forkhead box P1",TRUE
+"224838_at",0.896159990898752,0.579080743622024,-0.563010906783327,-5.78646180992804,-0.314338402148303,"FOXP1","forkhead box P1",TRUE
+"229844_at",0.918079643145802,0.652098717114448,-0.457030166034454,-5.83845631616107,-0.397288535370062,"FOXP1","forkhead box P1",TRUE
+"235444_at",0.950445326411157,0.774628151627025,0.289847386908597,-5.89884720917251,0.101991813688132,"FOXP1","forkhead box P1",TRUE
+"1558996_at",0.96200396340887,0.827515258046037,-0.220481332756167,-5.91603405677537,-0.11170622105128,"FOXP1","forkhead box P1",TRUE
+"223287_s_at",0.985425981490741,0.928973862491096,0.0901552802496222,-5.93572541928518,0.0485380689138939,"FOXP1","forkhead box P1",TRUE
+"1563157_at",0.85069818933195,0.453630436070582,0.762795681143516,-5.66018773599156,0.588677115299259,"FOXP1-AS1","FOXP1 antisense RNA 1",TRUE
+"232096_x_at",0.888972420461865,0.556416034286541,0.59721857427062,-5.76743999273147,0.24546621656962,"FOXP1-IT1","FOXP1 intronic transcript 1",TRUE
+"1555647_a_at",0.358427723880268,0.00993257138670694,-2.81985886787842,-2.66797331580943,-1.69197345924683,"FOXP2","forkhead box P2",TRUE
+"1555648_at",0.457115736805406,0.022657222619893,-2.4497265845945,-3.37563106358366,-1.5972184146703,"FOXP2","forkhead box P2",TRUE
+"1555352_at",0.71105346200454,0.184862949720636,1.36853231224578,-5.06645376068349,1.18177794783482,"FOXP2","forkhead box P2",TRUE
+"243278_at",0.729731101793347,0.211959023824054,-1.28530453165645,-5.16557119208962,-1.96572471199481,"FOXP2","forkhead box P2",TRUE
+"1562139_a_at",0.909863172642006,0.624847597738674,0.495900950628453,-5.82061064104855,0.208319808735175,"FOXP2","forkhead box P2",TRUE
+"1555516_at",0.920969133105816,0.663670486408215,0.440741517251681,-5.8455103071546,0.181515504837893,"FOXP2","forkhead box P2",TRUE
+"235201_at",0.955752634534966,0.798264422448786,-0.258687426612536,-5.90714207199221,-0.307211725300641,"FOXP2","forkhead box P2",TRUE
+"1552902_a_at",0.986455005400648,0.936881346681445,0.0800942376928678,-5.9365594113996,0.0474110008269295,"FOXP2","forkhead box P2",TRUE
+"1564876_s_at",0.988948717228281,0.946605252262,0.0677335726643616,-5.93744916159284,0.0365704855047939,"FOXP2","forkhead box P2",TRUE
+"221334_s_at",0.943988850936011,0.749501632590406,0.323297269555076,-5.88890292487425,0.130167132881552,"FOXP3","forkhead box P3",TRUE
+"224211_at",0.976335130930535,0.885697006552548,0.145416261064788,-5.92938934314587,0.108771619728633,"FOXP3","forkhead box P3",TRUE
+"221333_at",0.97897951922649,0.897923945306669,-0.12976406419022,-5.93148529132326,-0.0638437470290687,"FOXP3","forkhead box P3",TRUE
+"227120_at",0.775598649207873,0.292918820438836,-1.07734010894542,-5.38964695921756,-0.346871317577891,"FOXP4","forkhead box P4",TRUE
+"229763_at",0.998047179825832,0.991347896515433,-0.01096703714555,-5.9396248989607,-0.00766346070489821,"FOXP4","forkhead box P4",TRUE
+"238898_at",0.932742319779223,0.702937654612528,0.38632952383841,-5.86724936367909,0.339871542738684,"FOXP4-AS1","FOXP4 antisense RNA 1",TRUE
+"227475_at",0.0235179401762595,1.91610500849918e-05,5.4104870325943,2.81499435468303,5.36285129336561,"FOXQ1","forkhead box Q1",TRUE
+"237613_at",0.67606695078322,0.142530131910274,1.52049405888799,-4.87231325398284,0.56747892981323,"FOXR1","forkhead box R1",TRUE
+"1569669_at",0.805746717966166,0.345550080990883,0.96379615522514,-5.49710168303805,0.338128656720837,"FOXR2","forkhead box R2",TRUE
+"223128_at",0.384586587899771,0.0125437287423237,-2.71688782615628,-2.869544816058,-0.966710946408917,"FOXRED1","FAD dependent oxidoreductase domain containing 1",TRUE
+"220707_s_at",0.574207162627168,0.0604477901188851,-1.97840543010236,-4.19430459268971,-0.975785658016067,"FOXRED2","FAD dependent oxidoreductase domain containing 2",TRUE
+"231846_at",0.578441573439199,0.061723817057827,-1.96786652157996,-4.21133056397046,-0.982501605344069,"FOXRED2","FAD dependent oxidoreductase domain containing 2",TRUE
+"233250_x_at",0.774230543658252,0.28676344816115,-1.09153926990857,-5.3754544503573,-0.91353075610297,"FOXRED2","FAD dependent oxidoreductase domain containing 2",TRUE
+"229731_at",0.629285857609846,0.100133277754104,-1.71589400402462,-4.59914516921856,-0.956088150453279,"FOXS1","forkhead box S1",TRUE
+"202945_at",0.997674669021782,0.988723814118936,-0.0142934212045769,-5.93958397332104,-0.00503303238419051,"FPGS","folylpolyglutamate synthase",TRUE
+"205140_at",0.901542533614314,0.598357118606241,-0.534443676138894,-5.80151307118588,-0.200626505114148,"FPGT","fucose-1-phosphate guanylyltransferase",TRUE
+"220415_at",0.767728053775839,0.270263616285533,1.13072186596245,-5.33543454168273,0.605349491199624,"FPGT-TNNI3K///TNNI3K","FPGT-TNNI3K readthrough///TNNI3 interacting kinase",TRUE
+"205119_s_at",0.605913415325856,0.0793532461333604,1.83902004711344,-4.41437649075961,1.62768220569419,"FPR1","formyl peptide receptor 1",TRUE
+"205118_at",0.638865555358241,0.109772357215721,1.66608889189903,-4.67117532209753,1.22919770198649,"FPR1","formyl peptide receptor 1",TRUE
+"210773_s_at",0.775351898377291,0.292194022095886,1.07900085724674,-5.38799555388343,0.769753778228529,"FPR2","formyl peptide receptor 2",TRUE
+"210772_at",0.806735395676905,0.348002015949572,0.958808060874548,-5.50157299634434,0.805891592654263,"FPR2","formyl peptide receptor 2",TRUE
+"214560_at",0.637485146909712,0.10899449038342,1.66996765016313,-4.66562334254188,0.746172327706081,"FPR3","formyl peptide receptor 3",TRUE
+"230422_at",0.737002309471497,0.222334084909426,1.25562063577206,-5.19964430959595,0.672754997977612,"FPR3","formyl peptide receptor 3",TRUE
+"244767_at",0.73936001229895,0.22702767632491,-1.24253980670752,-5.214442705387,-1.25505041373109,"FRA10AC1","fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1",TRUE
+"226398_s_at",0.769393110223875,0.276756210015597,-1.11510139722399,-5.35153877697079,-0.624346929607553,"FRA10AC1","fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1",TRUE
+"238596_at",0.897300940949134,0.583510137110755,-0.556405462695667,-5.79000965204329,-0.282406329251898,"FRA10AC1","fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1",TRUE
+"226145_s_at",0.627092759817312,0.0984912564669335,1.72478141066126,-4.58612457985043,2.00729678214688,"FRAS1","Fraser extracellular matrix complex subunit 1",TRUE
+"243935_at",0.705559553212919,0.177144983839731,-1.39398906067346,-5.03510035628047,-1.21683413654628,"FRAS1","Fraser extracellular matrix complex subunit 1",TRUE
+"220910_at",0.729083413548563,0.211201346333251,1.2875158120622,-5.16300577544147,0.626656767784246,"FRAS1","Fraser extracellular matrix complex subunit 1",TRUE
+"231511_at",0.73826901296725,0.225171332230047,1.24768844499143,-5.20863391753457,0.991591594509729,"FRAS1","Fraser extracellular matrix complex subunit 1",TRUE
+"1552503_at",0.740610299769501,0.230629649108177,1.23264038461097,-5.22555330286989,0.571551257743675,"FRAS1","Fraser extracellular matrix complex subunit 1",TRUE
+"1560153_at",0.806422472374043,0.347391066351379,0.960048704286672,-5.50046286926374,0.616051927561683,"FRAS1","Fraser extracellular matrix complex subunit 1",TRUE
+"219889_at",0.77766827327863,0.296700725570038,-1.06872199298377,-5.39818006917681,-0.408599842404603,"FRAT1","frequently rearranged in advanced T-cell lymphomas 1",TRUE
+"209864_at",0.723973974120865,0.200880484845944,-1.31826730647417,-5.12694203395281,-0.621637527138262,"FRAT2","frequently rearranged in advanced T-cell lymphomas 2",TRUE
+"236031_x_at",0.93613089056626,0.714605940037294,0.370394439059129,-5.87308231312484,0.255512015404828,"FREM1","FRAS1 related extracellular matrix 1",TRUE
+"228233_at",0.992816117752561,0.966017568294866,-0.0430877075331189,-5.93877926388683,-0.0300203377778008,"FREM1","FRAS1 related extracellular matrix 1",TRUE
+"230964_at",0.643668420247444,0.114247416225792,-1.64421444423729,-4.7023015932077,-2.77687351395196,"FREM2","FRAS1 related extracellular matrix protein 2",TRUE
+"243337_at",0.429284714913652,0.0189579853181165,-2.53133647289985,-3.22383662875756,-2.08781134367162,"FREM3","FRAS1 related extracellular matrix 3",TRUE
+"234949_at",0.612403923106707,0.0839164186907261,1.80978203368981,-4.45909513352051,0.932654841967875,"FRG1BP","FSHD region gene 1 family member B, pseudogene",TRUE
+"243689_s_at",0.698480416742743,0.169767230249244,1.41916288223685,-5.00362625611598,0.748269669114753,"FRG1BP","FSHD region gene 1 family member B, pseudogene",TRUE
+"215160_x_at",0.391240007651669,0.0131335176022561,2.69646680669015,-2.9091194476041,1.21504033095951,"FRG1CP///FRG1JP","FSHD region gene 1 family member C, pseudogene///FSHD region gene 1 family member J, pseudogene",TRUE
+"241484_x_at",0.740681080735184,0.230927886105199,1.23182601282564,-5.22646390146663,0.898420886196146,"FRG1CP///LOC283788","FSHD region gene 1 family member C, pseudogene///FSHD region gene 1 pseudogene",TRUE
+"242249_at",0.64513208805899,0.116245425548301,1.63468019557741,-4.7157697918683,0.624838733895593,"FRG1EP","FSHD region gene 1 family member E, pseudogene",TRUE
+"232140_at",0.808257777979515,0.350603215093631,-0.95354234852293,-5.50627013319362,-0.403602732693351,"FRG1HP","FSHD region gene 1 family member H, pseudogene",TRUE
+"242331_x_at",0.740610299769501,0.230519321113601,1.23294185108602,-5.22521608325771,1.0870661336212,"FRG1JP","FSHD region gene 1 family member J, pseudogene",TRUE
+"242770_at",0.813418501361393,0.363344564565182,0.92812372892914,-5.52861033165717,0.624760569582655,"FRG1JP","FSHD region gene 1 family member J, pseudogene",TRUE
+"240246_at",0.8920930097751,0.563991145912784,0.585707348437718,-5.77396220160966,0.510096431920545,"FRG1JP","FSHD region gene 1 family member J, pseudogene",TRUE
+"235535_x_at",0.901781358899845,0.59891360750531,0.533625727702398,-5.80193280760459,0.337052520436468,"FRG1KP///LOC101930531///LOC101930278///FRG1CP///LOC100134091///FRG1BP///FRG1","FSHD region gene 1 family member K, pseudogene///uncharacterized LOC101930531///uncharacterized LOC101930278///FSHD region gene 1 family member C, pseudogene///protein FRG1B-like///FSHD region gene 1 family member B, pseudogene///FSHD region gene 1",TRUE
+"234830_at",0.79220528400952,0.322982130514059,-1.01088938112839,-5.45384677409104,-0.702004458990858,"FRG2EP","FSHD region gene 2 family member E, pseudogene",TRUE
+"207178_s_at",0.697097569641853,0.166687896345756,1.4299295119069,-4.99002378923693,1.1757689921774,"FRK","fyn related Src family tyrosine kinase",TRUE
+"235924_at",0.822170583627284,0.386010404786692,0.88433681829358,-5.56578870967988,0.764741168664568,"FRK","fyn related Src family tyrosine kinase",TRUE
+"220819_at",0.797508506396963,0.330899502166806,0.994116690150981,-5.46946747741006,0.56769077284991,"FRMD1","FERM domain containing 1",TRUE
+"230645_at",0.594303508881191,0.0711899573419713,1.89518425319631,-4.32704840435488,1.74466715849223,"FRMD3","FERM domain containing 3",TRUE
+"242600_at",0.644844656970274,0.115056844053322,1.64033520119383,-4.70778871089923,1.42169677773712,"FRMD3","FERM domain containing 3",TRUE
+"229893_at",0.711823634626804,0.185289255828352,1.36715091536244,-5.06814139487739,1.0748966282011,"FRMD3","FERM domain containing 3",TRUE
+"1554033_at",0.622434989367596,0.0926868801249257,1.75724727982413,-4.53813606917878,0.736821511837307,"FRMD4A","FERM domain containing 4A",TRUE
+"1554034_a_at",0.877948371309952,0.529579013786429,0.638679143215146,-5.74293440569634,0.466375657699635,"FRMD4A","FERM domain containing 4A",TRUE
+"225168_at",0.917381612608194,0.650279685015878,0.459602015874385,-5.83731960940165,0.24096033300863,"FRMD4A","FERM domain containing 4A",TRUE
+"208475_at",0.920749013376768,0.662901508205399,-0.441820147849645,-5.84505095726662,-0.298143741330031,"FRMD4A","FERM domain containing 4A",TRUE
+"225163_at",0.935351255251442,0.712614774603921,-0.373106705768191,-5.87210661639668,-0.160688751651263,"FRMD4A","FERM domain containing 4A",TRUE
+"208476_s_at",0.960857829396113,0.822053702497617,0.227587799447917,-5.91448690036022,0.163499287666987,"FRMD4A","FERM domain containing 4A",TRUE
+"225167_at",0.970957388308028,0.861155293531466,0.176949912184273,-5.92444441188526,0.0842372849825068,"FRMD4A","FERM domain containing 4A",TRUE
+"1560031_at",0.996625121774816,0.983227417805827,0.0212614380417925,-5.93946330686953,0.0142650975164385,"FRMD4A","FERM domain containing 4A",TRUE
+"216131_at",0.687949239097856,0.157319237977878,1.46370146292392,-4.94681271893298,0.78390981999486,"FRMD4B","FERM domain containing 4B",TRUE
+"213056_at",0.774209477315394,0.285975910559312,1.09337175206594,-5.37361076119779,0.703697229739772,"FRMD4B","FERM domain containing 4B",TRUE
+"216134_at",0.981944022360435,0.913429035948868,-0.109962492726782,-5.93379575082637,-0.0702687450827235,"FRMD4B","FERM domain containing 4B",TRUE
+"1569470_a_at",0.463632028061434,0.0237365385808246,2.42825133064177,-3.41513387263318,1.48586427933808,"FRMD5","FERM domain containing 5",TRUE
+"230831_at",0.579119470758542,0.0622978984745633,1.96318782260509,-4.21886937870294,2.41142435145939,"FRMD5","FERM domain containing 5",TRUE
+"225481_at",0.413914506615876,0.0166928484149613,2.58900219266246,-3.11504260197679,1.86839052849214,"FRMD6","FERM domain containing 6",TRUE
+"225464_at",0.527826453640453,0.0404314147481453,2.17674294175359,-3.86284367698756,1.54643785222188,"FRMD6","FERM domain containing 6",TRUE
+"233106_at",0.901788521024914,0.599594767277577,0.532625034423155,-5.80244547023096,0.284706321243769,"FRMD6-AS1","FRMD6 antisense RNA 1",TRUE
+"233047_at",0.812302873476553,0.358158891582204,0.938395444783846,-5.519649320946,0.609251633587157,"FRMD7","FERM domain containing 7",TRUE
+"1554905_x_at",0.707694888507328,0.179183026541455,-1.38718259128409,-5.0435303640931,-0.461820582455388,"FRMD8","FERM domain containing 8",TRUE
+"210043_at",0.800342373547779,0.336111693648879,0.983225894692175,-5.47948309470253,0.481635081051947,"FRMD8","FERM domain containing 8",TRUE
+"1554903_at",0.863739823286196,0.489349881410392,-0.70304463793467,-5.70176745062306,-0.307377217941342,"FRMD8","FERM domain containing 8",TRUE
+"227964_at",0.909441542080538,0.623709730286126,-0.497540543013927,-5.81982662392656,-0.212323316322749,"FRMD8","FERM domain containing 8",TRUE
+"224271_x_at",0.983935461205724,0.92132959323239,-0.0998904837058212,-5.93482468018641,-0.0686172151684499,"FRMD8P1","FERM domain containing 8 pseudogene 1",TRUE
+"206774_at",0.931003696369841,0.694723727630419,-0.397608226376151,-5.86297452545616,-0.259247794853315,"FRMPD1","FERM and PDZ domain containing 1",TRUE
+"236688_at",0.639705117673934,0.110237194922084,-1.66378209018783,-4.67447257764606,-0.758588650199411,"FRMPD3","FERM and PDZ domain containing 3",TRUE
+"239290_at",0.868714861166452,0.50495067236016,0.677743684964013,-5.71840035832355,0.400323118543906,"FRMPD4","FERM and PDZ domain containing 4",TRUE
+"215052_at",0.981944022360435,0.913622601023553,0.109715591753081,-5.93382215315983,0.0853093674590637,"FRMPD4","FERM and PDZ domain containing 4",TRUE
+"1570207_at",0.872540606821582,0.515884699648695,0.66027321057523,-5.72954507430464,0.650264939816182,"FRRS1","ferric chelate reductase 1",TRUE
+"239097_at",0.755940660414394,0.250522677797975,1.17997920116506,-5.28336200850588,0.658220880405386,"FRRS1L","ferric chelate reductase 1 like",TRUE
+"213904_at",0.842664863388981,0.436474969020136,0.792496595166543,-5.63832705385143,0.829119099024441,"FRRS1L","ferric chelate reductase 1 like",TRUE
+"1558414_at",0.973433731874338,0.871684841412274,0.163399903025666,-5.92668748577494,0.0684338038476904,"FRRS1L","ferric chelate reductase 1 like",TRUE
+"238486_at",0.55074985379986,0.0491070280829719,-2.0819080209572,-4.02388741664858,-1.35424559679985,"FRS2","fibroblast growth factor receptor substrate 2",TRUE
+"226045_at",0.627092759817312,0.0985081587660983,-1.72468928579297,-4.58625980568043,-1.29722321144283,"FRS2","fibroblast growth factor receptor substrate 2",TRUE
+"221308_at",0.788758616802423,0.314957993537111,-1.02818322865604,-5.43749309994972,-0.934485834693094,"FRS2","fibroblast growth factor receptor substrate 2",TRUE
+"219907_at",0.9089753392553,0.621810619823077,0.500280121750962,-5.81851097972333,0.161268824908965,"FRS3","fibroblast growth factor receptor substrate 3",TRUE
+"214318_s_at",0.825343734281993,0.39275342073249,0.871637398168885,-5.57626019925905,0.701165949628821,"FRY","FRY microtubule binding protein",TRUE
+"214319_at",0.863408882018863,0.487953310550182,-0.705331920153546,-5.70023512397883,-0.540039541515976,"FRY","FRY microtubule binding protein",TRUE
+"1555904_at",0.904642636636096,0.608687577806469,0.519318820856411,-5.80917328770752,0.297566012802558,"FRY","FRY microtubule binding protein",TRUE
+"204072_s_at",0.986342822130003,0.935343278265047,-0.082050493666049,-5.93640496556742,-0.0783637940714517,"FRY","FRY microtubule binding protein",TRUE
+"1558793_at",0.635174103121116,0.106046639042119,-1.68488257908395,-4.64418325097947,-1.71268661660349,"FRY-AS1","FRY antisense RNA 1",TRUE
+"212546_s_at",0.48580305784244,0.0284557150356292,2.34385287207332,-3.56851534496188,0.760364435869315,"FRYL","FRY like transcription coactivator",TRUE
+"1563687_a_at",0.587626678796111,0.0664298012576326,1.93059318607131,-4.2710485866606,0.68634440115096,"FRYL","FRY like transcription coactivator",TRUE
+"1554260_a_at",0.671498069723584,0.137642235001774,1.54032568833733,-4.84576527587023,0.55457219472432,"FRYL","FRY like transcription coactivator",TRUE
+"1562625_at",0.929799176551038,0.690202640685879,-0.403838593450697,-5.86056115795509,-0.176981981209833,"FRYL","FRY like transcription coactivator",TRUE
+"212548_s_at",0.968451827985008,0.852021532836967,0.188731178023126,-5.92234943278083,0.0570878142290674,"FRYL","FRY like transcription coactivator",TRUE
+"1562650_at",0.984801578023171,0.925397504466252,0.0947087083256661,-5.93531559552048,0.0771356767924911,"FRYL","FRY like transcription coactivator",TRUE
+"203698_s_at",0.733985531576126,0.218255578335613,1.26715993623309,-5.18647958784993,2.04057840427327,"FRZB","frizzled-related protein",TRUE
+"231273_x_at",0.739189560382301,0.225984272598437,1.24542975594207,-5.21118475429049,0.612026118361348,"FRZB","frizzled-related protein",TRUE
+"244419_at",0.763850302870073,0.263825777698102,1.14648454187963,-5.31898332199532,0.935497601583765,"FRZB","frizzled-related protein",TRUE
+"203697_at",0.8485419825626,0.448965101556216,0.770804030548837,-5.65437095192637,1.13387532373811,"FRZB","frizzled-related protein",TRUE
+"220549_at",0.915353407558177,0.642586267774256,0.470514548116303,-5.83242699570084,0.199814781955975,"FSBP///RAD54B","fibrinogen silencer binding protein///RAD54 homolog B (S. cerevisiae)",TRUE
+"235846_at",0.97689149311934,0.889529197992,-0.140506703373572,-5.93007238749163,-0.0637543747413503,"FSBP///RAD54B","fibrinogen silencer binding protein///RAD54 homolog B (S. cerevisiae)",TRUE
+"224274_at",0.899808883319249,0.593306807531462,-0.541883798955403,-5.79766640987207,-0.494588801737637,"FSCB","fibrous sheath CABYR binding protein",TRUE
+"201564_s_at",0.0934925515876652,0.000379613103840177,4.18455376275509,0.197811787216842,4.44781525803659,"FSCN1","fascin actin-bundling protein 1",TRUE
+"210933_s_at",0.185392143728903,0.00181461927348349,3.54211706506705,-1.18162505078594,4.04577384998976,"FSCN1","fascin actin-bundling protein 1",TRUE
+"207204_at",0.726696341943087,0.20666759943633,-1.30087733155847,-5.14742471537909,-0.799797691304531,"FSCN2","fascin actin-bundling protein 2, retinal",TRUE
+"220379_at",0.750807729565285,0.243852497629351,-1.19727436629298,-5.26461806483989,-0.367624742190618,"FSCN3","fascin actin-bundling protein 3",TRUE
+"219170_at",0.698391916012681,0.169594922721268,1.41976118688435,-5.00287257632886,1.90117357994986,"FSD1","fibronectin type III and SPRY domain containing 1",TRUE
+"242807_at",0.915611754226485,0.644272427516003,-0.468117937533323,-5.83351114508052,-0.191694166154566,"FSD1L","fibronectin type III and SPRY domain containing 1 like",TRUE
+"230904_at",0.919354071504066,0.656564219941907,0.450729792971158,-5.84121453561378,0.316813285879468,"FSD1L","fibronectin type III and SPRY domain containing 1 like",TRUE
+"223985_at",0.919959462096257,0.659402914430537,0.446734309975927,-5.8429442502296,0.475922912184579,"FSD1L","fibronectin type III and SPRY domain containing 1 like",TRUE
+"242586_at",0.950031925101785,0.773113000067926,-0.291854521874001,-5.89828084640823,-0.219931226677981,"FSD1L","fibronectin type III and SPRY domain containing 1 like",TRUE
+"237222_at",0.687734660055697,0.156947543998107,-1.46507450536605,-4.94503857932381,-0.948747813308855,"FSD2","fibronectin type III and SPRY domain containing 2",TRUE
+"214489_at",0.948668195792872,0.766367707471601,-0.300805074716521,-5.89570805060629,-0.191181461756693,"FSHB","follicle stimulating hormone beta subunit",TRUE
+"211201_at",0.872238421308015,0.515169386876577,0.661409793386422,-5.72882850899535,0.284180038982277,"FSHR","follicle stimulating hormone receptor",TRUE
+"1553622_a_at",0.871165715950006,0.511821283192456,-0.666741396605403,-5.72545140421113,-1.03863920237927,"FSIP1","fibrous sheath interacting protein 1",TRUE
+"240028_at",0.784789297644843,0.309274228799198,-1.04062104863305,-5.4255767415308,-1.10228755381276,"FSIP2","fibrous sheath interacting protein 2",TRUE
+"226847_at",0.558021698679157,0.0526535700683269,2.04743101574118,-4.08128995357464,3.24562905870844,"FST","follistatin",TRUE
+"207345_at",0.592111379991983,0.069289948089029,1.90906091749893,-4.30518805244849,1.38333354775926,"FST","follistatin",TRUE
+"204948_s_at",0.610455440146151,0.0829803246022683,1.81566565049028,-4.4501377757042,1.7595430261683,"FST","follistatin",TRUE
+"208782_at",0.610198729812125,0.0827145370106629,1.81734667083763,-4.44757469950156,2.8601528112852,"FSTL1","follistatin like 1",TRUE
+"230744_at",0.6997282151361,0.171223846187579,1.41412440157687,-5.00996283775112,0.970788028196594,"FSTL1","follistatin like 1",TRUE
+"203592_s_at",0.565993041605217,0.0568943152158333,2.00882899705074,-4.14481099853932,0.85733084158375,"FSTL3","follistatin like 3",TRUE
+"214859_at",0.710383535193614,0.183361890609398,1.37341646938871,-5.06047547736935,0.901369460592298,"FSTL4","follistatin like 4",TRUE
+"1564511_a_at",0.85463333818278,0.466292135092061,-0.741307471573881,-5.67551136064391,-0.52139139218695,"FSTL4","follistatin like 4",TRUE
+"1565910_at",0.92777930247318,0.683219341948528,-0.41349422213864,-5.85674803612165,-0.238619372728928,"FSTL4","follistatin like 4",TRUE
+"232010_at",0.497725944448536,0.0305664533538277,2.31021685605832,-3.62878625354883,2.73073844668129,"FSTL5","follistatin like 5",TRUE
+"224300_x_at",0.632949074657601,0.103749019549492,-1.69675315975643,-4.62701650368821,-1.00839955766649,"FTCD","formimidoyltransferase cyclodeaminase",TRUE
+"233741_at",0.728622545366091,0.210059584371577,-1.29085965149123,-5.15911929720759,-0.737036086742169,"FTCD","formimidoyltransferase cyclodeaminase",TRUE
+"224299_x_at",0.733012446828677,0.217545882181282,1.26918474301698,-5.18415894235389,1.07777303839132,"FTCD","formimidoyltransferase cyclodeaminase",TRUE
+"223702_x_at",0.932110304875832,0.700749190153017,0.389329504140433,-5.86612414751804,0.327179069317578,"FTCD","formimidoyltransferase cyclodeaminase",TRUE
+"220604_x_at",0.946277807642742,0.756675701377635,0.313709984391485,-5.89186302132289,0.231699814143308,"FTCD","formimidoyltransferase cyclodeaminase",TRUE
+"223979_x_at",0.98539961718117,0.928205401211603,0.0911335190108598,-5.93563907588848,0.0672712559232602,"FTCD","formimidoyltransferase cyclodeaminase",TRUE
+"1556667_at",0.721868021715132,0.197981134840234,-1.3271268773324,-5.11641857263873,-1.04390440837701,"FTCDNL1","formiminotransferase cyclodeaminase N-terminal like",TRUE
+"243744_at",0.774230543658252,0.290283909214988,1.08339176498395,-5.38361840942891,0.751137457134877,"FTCDNL1","formiminotransferase cyclodeaminase N-terminal like",TRUE
+"200748_s_at",0.924945974005481,0.675248624644331,0.424564268119308,-5.85226732912899,0.127237572586653,"FTH1","ferritin heavy chain 1",TRUE
+"214211_at",0.995618448898906,0.979038298851392,-0.026572869185575,-5.93933956286149,-0.010038890938203,"FTH1","ferritin heavy chain 1",TRUE
+"211628_x_at",0.99164669139131,0.960600691198634,0.049961550357513,-5.93846776807453,0.0111137065340525,"FTH1P5","ferritin heavy chain 1 pseudogene 5",TRUE
+"224379_at",0.597654932724127,0.0737445764696201,1.87702911108548,-4.35548007456203,1.71254272808632,"FTHL17","ferritin heavy chain like 17",TRUE
+"213187_x_at",0.743988868190873,0.23476982062912,1.22140582414207,-5.23806947999886,0.579152129277837,"FTL","ferritin light chain",TRUE
+"212788_x_at",0.7768734672127,0.294909217802996,1.07279457087422,-5.39415529897481,0.361628726908592,"FTL","ferritin light chain",TRUE
+"209702_at",0.870808709484996,0.510088240983086,-0.669508772492628,-5.72368827399536,-0.275455899851988,"FTO","fat mass and obesity associated",TRUE
+"205324_s_at",0.603702127972549,0.0781228641574214,1.84715310121607,-4.40184605242549,0.587232895024661,"FTSJ1","FtsJ RNA methyltransferase homolog 1 (E. coli)",TRUE
+"213937_s_at",0.635626505801859,0.106652721796548,1.68178763921622,-4.64864406808491,0.583254741024364,"FTSJ1","FtsJ RNA methyltransferase homolog 1 (E. coli)",TRUE
+"218103_at",0.992129073515375,0.963476639915361,0.0463117783073335,-5.9386388910857,0.0183660639638088,"FTSJ3","FtsJ homolog 3",TRUE
+"1558515_at",0.889389445320988,0.55714992090345,0.596099808502415,-5.76807926286725,0.359598568877385,"FTX","FTX transcript, XIST regulator (non-protein coding)",TRUE
+"242121_at",0.960138290470901,0.819600453730116,0.230783800092924,-5.91377517657997,0.154726876184814,"FTX","FTX transcript, XIST regulator (non-protein coding)",TRUE
+"203091_at",0.78969417320323,0.317750065879517,1.02213105554678,-5.44324476596304,0.327177188661981,"FUBP1","far upstream element binding protein 1",TRUE
+"214094_at",0.952237574337645,0.781261510921593,-0.281074290258733,-5.90127723837057,-0.218595694233544,"FUBP1","far upstream element binding protein 1",TRUE
+"214093_s_at",0.958151088213963,0.810980945532225,0.242032727483578,-5.91119160888458,0.106715069829127,"FUBP1","far upstream element binding protein 1",TRUE
+"212847_at",0.962555471240652,0.829095702366232,-0.218427071103264,-5.91647219162709,-0.0724222624775557,"FUBP1","far upstream element binding protein 1",TRUE
+"212824_at",0.929332398252332,0.689307133082443,-0.405074588422549,-5.86007799744297,-0.118451505425369,"FUBP3","far upstream element binding protein 3",TRUE
+"239193_at",0.955892698633978,0.799994925113211,-0.256416712178047,-5.90770995152423,-0.093553615821028,"FUBP3","far upstream element binding protein 3",TRUE
+"202838_at",0.48580305784244,0.0285750824695251,2.34189044601024,-3.5720454320767,1.19536425530351,"FUCA1","fucosidase, alpha-L- 1, tissue",TRUE
+"229137_at",0.683017520100356,0.151333028705851,1.48614246669065,-4.91764765531733,0.597244926606105,"FUCA1","fucosidase, alpha-L- 1, tissue",TRUE
+"223120_at",0.96351240321323,0.833922293813396,0.212159373192371,-5.91778373954648,0.0940274363228824,"FUCA2","fucosidase, alpha-L- 2, plasma",TRUE
+"226072_at",0.692209287833119,0.16152561075947,-1.44834315089435,-4.96656545934025,-0.704202160416415,"FUK","fucokinase",TRUE
+"235346_at",0.407654835118497,0.0155009492859873,-2.62236198763108,-3.05155029522444,-0.862903179049678,"FUNDC1","FUN14 domain containing 1",TRUE
+"223042_s_at",0.820291269575398,0.378940227681474,-0.897808893326082,-5.55452672277469,-0.366338661472522,"FUNDC2","FUN14 domain containing 2",TRUE
+"230922_x_at",0.960614707352139,0.821090452191044,-0.228842395001555,-5.91420868932858,-0.0864665652395349,"FUNDC2","FUN14 domain containing 2",TRUE
+"230259_at",0.471502518944839,0.0256599835188109,2.39212954208618,-3.48114905389876,1.81656149163361,"FUOM","fucose mutarotase",TRUE
+"201945_at",0.369687273960354,0.0111159739989176,2.77035327470043,-2.76529488514631,1.54832006927698,"FURIN","furin, paired basic amino acid cleaving enzyme",TRUE
+"200959_at",0.84932977991296,0.450350610872549,-0.76842047927947,-5.65610821834381,-0.206746552121885,"FUS","FUS RNA binding protein",TRUE
+"217370_x_at",0.863468033337798,0.488138249736107,-0.705028813100061,-5.700438458175,-0.253931646239696,"FUS","FUS RNA binding protein",TRUE
+"215744_at",0.873350188241469,0.518547181726252,-0.656050364600834,-5.73219703971418,-0.169325316898902,"FUS","FUS RNA binding protein",TRUE
+"231108_at",0.93613089056626,0.714439037881845,-0.370621675963977,-5.87300083771333,-0.151155448920667,"FUS","FUS RNA binding protein",TRUE
+"1565717_s_at",0.952697366942815,0.783675595590831,-0.277887108925253,-5.90214169152421,-0.12367116506295,"FUS","FUS RNA binding protein",TRUE
+"1565716_at",0.958931830316768,0.814025559747584,-0.238055768665221,-5.9121189785299,-0.0765675883287855,"FUS","FUS RNA binding protein",TRUE
+"206109_at",0.974536463688956,0.875669764908015,-0.158280178634719,-5.9274886372786,-0.0748766017447053,"FUT1","fucosyltransferase 1 (H blood group)",TRUE
+"235472_at",0.768311775820646,0.271494378952323,1.1277398725755,-5.33852418418564,0.413911060194081,"FUT10","fucosyltransferase 10",TRUE
+"239020_at",0.864079461576774,0.491187445683204,0.700040818982688,-5.70377260086302,0.205558956021525,"FUT10","fucosyltransferase 10",TRUE
+"223976_at",0.954757258960344,0.794330099599235,0.263855125652336,-5.90583114911622,0.120249699373071,"FUT10","fucosyltransferase 10",TRUE
+"238551_at",0.724970327905974,0.202834971809124,1.31235108486946,-5.13393623347585,0.898743667952592,"FUT11","fucosyltransferase 11",TRUE
+"226348_at",0.757361197594703,0.253216122064806,1.17309279221517,-5.29075899929838,0.540337771698498,"FUT11","fucosyltransferase 11",TRUE
+"210608_s_at",0.622434989367596,0.0925344187801318,1.75812326630204,-4.53683209485421,0.680513127340045,"FUT2","fucosyltransferase 2",TRUE
+"208505_s_at",0.687545925823023,0.156408255401576,1.4670713359751,-4.94245602362684,1.22267307074035,"FUT2","fucosyltransferase 2",TRUE
+"214088_s_at",0.522016286799917,0.0380142557977644,2.20644755811679,-3.81148236785717,1.73473654799801,"FUT3","fucosyltransferase 3 (Lewis blood group)",TRUE
+"216010_x_at",0.589349984422749,0.0677939541398172,1.92022378329663,-4.28752239352668,1.53874050348942,"FUT3","fucosyltransferase 3 (Lewis blood group)",TRUE
+"209893_s_at",0.714795139167042,0.190320972764,1.35103284245682,-5.08772749233276,1.1931305740909,"FUT4","fucosyltransferase 4",TRUE
+"209892_at",0.767727587789514,0.270195032946389,1.13088832772351,-5.33526185834262,1.25703164590836,"FUT4","fucosyltransferase 4",TRUE
+"211225_at",0.73223722457785,0.216394550583582,-1.27248038794749,-5.18037501060654,-0.711623928888271,"FUT5","fucosyltransferase 5",TRUE
+"211882_x_at",0.671498069723584,0.137539890431632,1.54074708341537,-4.84519820635207,1.59480362996458,"FUT6","fucosyltransferase 6",TRUE
+"210398_x_at",0.683017520100356,0.151541922136926,1.48534732672661,-4.91868716281105,1.95913602142281,"FUT6","fucosyltransferase 6",TRUE
+"211885_x_at",0.724970327905974,0.203090690718245,1.3115803136879,-5.13484548744165,1.43358003562808,"FUT6","fucosyltransferase 6",TRUE
+"211465_x_at",0.789661545166663,0.317130307651415,1.02347123057862,-5.4419737778958,0.447796016007938,"FUT6","fucosyltransferase 6",TRUE
+"1565660_at",0.861763798017736,0.484040539647588,-0.71176039472644,-5.69590308352662,-0.557775170125811,"FUT6","fucosyltransferase 6",TRUE
+"210399_x_at",0.872809248863504,0.517100421283501,0.658343515025831,-5.73075895596913,0.467391636600336,"FUT6","fucosyltransferase 6",TRUE
+"1565661_x_at",0.931582451098271,0.69817798308085,0.392858809171965,-5.8647894147659,0.256029961443042,"FUT6","fucosyltransferase 6",TRUE
+"1565659_at",0.951163538450312,0.776866190636253,-0.286884856420663,-5.89967607585666,-0.120228832591604,"FUT6","fucosyltransferase 6",TRUE
+"217696_at",0.528056136690037,0.0406234113200776,2.1744530643783,-3.86678520070143,1.68858940223022,"FUT7","fucosyltransferase 7",TRUE
+"210506_at",0.893928800286346,0.570087049078817,0.576501672411535,-5.77908970956039,0.312910377785891,"FUT7","fucosyltransferase 7",TRUE
+"1554930_a_at",0.751464513744428,0.244661569588824,1.19515777580543,-5.26692471211924,0.706066264460723,"FUT8","fucosyltransferase 8",TRUE
+"203988_s_at",0.784124594631274,0.307224820597918,1.04514533049064,-5.42121014404624,0.801548822470146,"FUT8","fucosyltransferase 8",TRUE
+"242889_x_at",0.637485146909712,0.108578405235034,1.67205203029556,-4.66263575091637,0.781149181779235,"FUT8-AS1","FUT8 antisense RNA 1",TRUE
+"236835_at",0.946391057046703,0.75769901689414,0.312344908449711,-5.89227731434604,0.315700545264264,"FUT8-AS1","FUT8 antisense RNA 1",TRUE
+"214046_at",0.768852835478002,0.272409861145042,1.12552817880671,-5.34081106246549,1.15884547910634,"FUT9","fucosyltransferase 9",TRUE
+"207696_at",0.969882914559333,0.856515355794032,0.182931468708685,-5.92339756936573,0.171200476015996,"FUT9","fucosyltransferase 9",TRUE
+"216185_at",0.973493137611142,0.872019465496122,-0.162969816795263,-5.92675576578021,-0.106554088426498,"FUT9","fucosyltransferase 9",TRUE
+"221187_s_at",0.851707246701086,0.455832783776263,0.759032479518018,-5.6629012679354,0.442272423800916,"FUZ","fuzzy planar cell polarity protein",TRUE
+"205565_s_at",0.739340500562926,0.226475364139284,-1.24406829929307,-5.21272038771056,-0.524391584408836,"FXN","frataxin",TRUE
+"230234_at",0.817857130700434,0.370641411017003,0.913834838245217,-5.54092490415119,0.662184080809392,"FXN","frataxin",TRUE
+"201635_s_at",0.51470556386048,0.0353868900695299,2.24074859789457,-3.75164688246819,0.844931611128017,"FXR1","FMR1 autosomal homolog 1",TRUE
+"201637_s_at",0.55937703282623,0.0535782497794928,2.03878365495904,-4.09558891560563,0.698150083511957,"FXR1","FMR1 autosomal homolog 1",TRUE
+"201636_at",0.69114521567028,0.160807670908785,1.45094143872153,-4.96323563585622,0.527273968151492,"FXR1","FMR1 autosomal homolog 1",TRUE
+"230201_at",0.897011777275924,0.582607337693072,0.557749746754352,-5.78929091792842,0.231116888531794,"FXR1","FMR1 autosomal homolog 1",TRUE
+"235960_at",0.977160030692682,0.891074003473604,-0.138528604378717,-5.93034097457868,-0.0489916788718432,"FXR1","FMR1 autosomal homolog 1",TRUE
+"229519_at",0.996118448346386,0.980588930487795,0.0246067228618052,-5.93938857280294,0.00934304613130621,"FXR1","FMR1 autosomal homolog 1",TRUE
+"35265_at",0.631316839203356,0.102518459959751,1.70320285483314,-4.6176511927285,0.430181548470891,"FXR2","FMR1 autosomal homolog 2",TRUE
+"203172_at",0.821187434813103,0.382539247289867,0.890930648600163,-5.56029629349239,0.280663736728261,"FXR2","FMR1 autosomal homolog 2",TRUE
+"205384_at",0.638134354959023,0.10941787977975,1.66785357034666,-4.6686506119876,1.27834797454582,"FXYD1","FXYD domain containing ion transport regulator 1",TRUE
+"205674_x_at",0.878788356961452,0.532101363441183,0.634735150578242,-5.74533366478684,0.239029241558827,"FXYD2","FXYD domain containing ion transport regulator 2",TRUE
+"1556294_at",0.946050828306305,0.755725167836622,-0.31497851617633,-5.89147642471111,-0.253808589667736,"FXYD2","FXYD domain containing ion transport regulator 2",TRUE
+"202488_s_at",0.834007912177137,0.411871013016824,-0.836379993823386,-5.6045927949021,-0.552329815086976,"FXYD3","FXYD domain containing ion transport regulator 3",TRUE
+"202489_s_at",0.938726197187622,0.726868432658603,0.353752411616005,-5.87891515370064,0.545074343339671,"FXYD3","FXYD domain containing ion transport regulator 3",TRUE
+"231058_at",0.926263798296325,0.679782610686685,0.418260765592727,-5.8548330000816,0.25375361327559,"FXYD4","FXYD domain containing ion transport regulator 4",TRUE
+"218084_x_at",0.407748633394319,0.0156506162301822,2.61804329656,-3.05979225312104,3.59654845600128,"FXYD5","FXYD domain containing ion transport regulator 5",TRUE
+"224252_s_at",0.422574093216884,0.0176458359466478,2.5638993786409,-3.16255404663827,3.86265548273012,"FXYD5","FXYD domain containing ion transport regulator 5",TRUE
+"217897_at",0.983364220761052,0.919029410901301,0.102821726829091,-5.93453541113825,0.161238804255793,"FXYD6","FXYD domain containing ion transport regulator 6",TRUE
+"207434_s_at",0.683838837468118,0.152722031620366,1.48087198990858,-4.92452952572954,1.07224789217184,"FXYD6-FXYD2///FXYD2","FXYD6-FXYD2 readthrough///FXYD domain containing ion transport regulator 2",TRUE
+"220131_at",0.603702127972549,0.0779299719951991,1.84843823917902,-4.39986245922605,0.901236897313973,"FXYD7","FXYD domain containing ion transport regulator 7",TRUE
+"211795_s_at",0.000480014612356878,5.2676500670165e-08,8.03020780244863,7.75989766920878,5.03595905624807,"FYB","FYN binding protein",TRUE
+"227266_s_at",0.00502305971781467,1.19432604173005e-06,6.59678857173678,5.19073281691138,4.95225937672434,"FYB","FYN binding protein",TRUE
+"211794_at",0.00894670147697473,3.6088958313953e-06,6.11604361423457,4.25280934087898,3.65617576248801,"FYB","FYN binding protein",TRUE
+"205285_s_at",0.0264460817671555,2.37011066591791e-05,5.3220360406758,2.63025074809599,3.0824830539804,"FYB","FYN binding protein",TRUE
+"224148_at",0.226811031406261,0.00280994238547518,3.35983043480326,-1.56609214395093,3.12328227213505,"FYB","FYN binding protein",TRUE
+"218204_s_at",0.833286032900483,0.410706758383214,-0.838496885947523,-5.60292247058905,-0.403148505297287,"FYCO1","FYVE and coiled-coil domain containing 1",TRUE
+"1555523_a_at",0.88136517545868,0.53800924243838,-0.625536852746641,-5.75087371986084,-0.20552163122051,"FYCO1","FYVE and coiled-coil domain containing 1",TRUE
+"216033_s_at",0.62524538993269,0.096597124988778,1.73519178072695,-4.57080906977855,2.64973297165918,"FYN","FYN proto-oncogene, Src family tyrosine kinase",TRUE
+"210105_s_at",0.683017520100356,0.151430549947171,1.48577114698579,-4.91813314714298,1.39715645836605,"FYN","FYN proto-oncogene, Src family tyrosine kinase",TRUE
+"243006_at",0.687659256779784,0.15667310189676,1.46608998960117,-4.94372558182378,0.841422690626709,"FYN","FYN proto-oncogene, Src family tyrosine kinase",TRUE
+"1559101_at",0.757950630724418,0.254441940070452,1.16997675867647,-5.29409362274006,0.711040639443332,"FYN","FYN proto-oncogene, Src family tyrosine kinase",TRUE
+"212486_s_at",0.784789297644843,0.308934642346487,1.04136925327423,-5.42485579048451,1.23544636990163,"FYN","FYN proto-oncogene, Src family tyrosine kinase",TRUE
+"224642_at",0.913157126234238,0.635446915440702,-0.480693284433321,-5.82776210306893,-0.174645390533207,"FYTTD1","forty-two-three domain containing 1",TRUE
+"224641_at",0.986342822130003,0.935278971580506,-0.0821322918755094,-5.93639842650282,-0.0277495161051728,"FYTTD1","forty-two-three domain containing 1",TRUE
+"204451_at",0.296964617886988,0.00540608078889835,-3.08307097546388,-2.13910848701579,-1.44969935873472,"FZD1","frizzled class receptor 1",TRUE
+"204452_s_at",0.451020270465914,0.0215961786571516,-2.47178458617521,-3.33486206203361,-0.84512627381635,"FZD1","frizzled class receptor 1",TRUE
+"236035_at",0.821424121108148,0.383601025610441,-0.88890954862001,-5.56198381205674,-0.815318014748225,"FZD1","frizzled class receptor 1",TRUE
+"219764_at",0.55937703282623,0.0530883661725597,2.04334817650066,-4.08804614792554,1.57339438430883,"FZD10","frizzled class receptor 10",TRUE
+"243351_at",0.756006545489432,0.250841964012876,1.17915999751941,-5.28424393297459,0.758220246697003,"FZD10-AS1","FZD10 antisense RNA 1 (head to head)",TRUE
+"239569_at",0.845588139978284,0.442946469518445,0.781210364929222,-5.64672676706029,0.497472298483646,"FZD10-AS1","FZD10 antisense RNA 1 (head to head)",TRUE
+"210220_at",0.757850812302788,0.253935542615416,1.17126266597531,-5.29271844946241,1.48796959289477,"FZD2","frizzled class receptor 2",TRUE
+"238129_s_at",0.766550448794594,0.267288555420648,1.13797143740631,-5.32789323146209,0.912243247665826,"FZD2","frizzled class receptor 2",TRUE
+"227499_at",0.879538460185128,0.53404513582489,-0.631702734489949,-5.74716866119455,-0.769296705447909,"FZD3","frizzled class receptor 3",TRUE
+"219683_at",0.910159094731364,0.625838381057466,0.494474418444162,-5.82129072146648,0.462780181298306,"FZD3","frizzled class receptor 3",TRUE
+"239082_at",0.98672253748883,0.93807426935556,0.078577190509772,-5.9366766177998,0.0500113229806747,"FZD3","frizzled class receptor 3",TRUE
+"227524_at",0.999987688030268,0.999987688030268,1.5605800462339e-05,-5.93968348063049,5.26678062051644e-06,"FZD3","frizzled class receptor 3",TRUE
+"218665_at",0.468735421183467,0.0248224731483196,-2.40753882807751,-3.45305401384858,-1.15685646708837,"FZD4","frizzled class receptor 4",TRUE
+"224337_s_at",0.971040109976404,0.86126418094551,-0.176809620614456,-5.92446854817494,-0.129707697067682,"FZD4","frizzled class receptor 4",TRUE
+"221245_s_at",0.83242103542195,0.408607755903863,0.842323022047721,-5.59989346974537,0.549524713766951,"FZD5","frizzled class receptor 5",TRUE
+"206136_at",0.990980060324272,0.957642848325075,0.0537159777156527,-5.93827820345922,0.043688752716255,"FZD5","frizzled class receptor 5",TRUE
+"203987_at",0.82153774281298,0.383908957793982,0.888324083407997,-5.56247198345826,1.41270318452102,"FZD6","frizzled class receptor 6",TRUE
+"203705_s_at",0.778686132916778,0.299427515095846,1.06255686760429,-5.40424674390485,0.914324400680119,"FZD7","frizzled class receptor 7",TRUE
+"203706_s_at",0.895213601869362,0.573355105667868,0.571587130033934,-5.78179487368095,0.564154958589912,"FZD7","frizzled class receptor 7",TRUE
+"207639_at",0.817915083386752,0.370920214395785,0.913292604439529,-5.54138874858296,0.482648550133782,"FZD9","frizzled class receptor 9",TRUE
+"209414_at",0.740230546948649,0.228588066843731,-1.23823676794028,-5.21928161739288,-0.471867001980156,"FZR1","fizzy/cell division cycle 20 related 1",TRUE
+"209416_s_at",0.774852179746145,0.29130473808289,1.08104254136156,-5.38596224316519,0.341582291142556,"FZR1","fizzy/cell division cycle 20 related 1",TRUE
+"209415_at",0.905462783815257,0.611489932959159,0.515237093239946,-5.81120383750609,0.143707689740721,"FZR1","fizzy/cell division cycle 20 related 1",TRUE
+"211865_s_at",0.928934183862811,0.686995038399502,0.408268757709965,-5.85882264038099,0.131810312258397,"FZR1","fizzy/cell division cycle 20 related 1",TRUE
+"213524_s_at",0.330171916405281,0.00795401311400347,2.91677590617857,-2.475371356569,3.05954260318216,"G0S2","G0/G1 switch 2",TRUE
+"223256_at",0.722937902375896,0.199432392959759,-1.32267968380359,-5.12170840793963,-0.337800884705599,"G2E3","G2/M-phase specific E3 ubiquitin protein ligase",TRUE
+"223255_at",0.851733415458562,0.456559150479384,-0.757793720073736,-5.66379172367435,-0.203532797616369,"G2E3","G2/M-phase specific E3 ubiquitin protein ligase",TRUE
+"223257_at",0.958473780774099,0.811826892455504,0.240927330755174,-5.91145090470267,0.0611212333365039,"G2E3","G2/M-phase specific E3 ubiquitin protein ligase",TRUE
+"223258_s_at",0.993225426079816,0.96812514036487,-0.0404138598531464,-5.93888800155675,-0.0118898323126881,"G2E3","G2/M-phase specific E3 ubiquitin protein ligase",TRUE
+"223254_s_at",0.995375928428862,0.978431309373028,0.0273425392740028,-5.93931935187324,0.00981420894380669,"G2E3","G2/M-phase specific E3 ubiquitin protein ligase",TRUE
+"242422_at",0.463632028061434,0.0237283513360181,2.42841079640536,-3.41484123730363,1.06760903868082,"G3BP1","G3BP stress granule assembly factor 1",TRUE
+"225007_at",0.503643681106548,0.0326642980009844,2.27883502877893,-3.68456153261759,0.680527342102451,"G3BP1","G3BP stress granule assembly factor 1",TRUE
+"201503_at",0.677013732819214,0.144194305190275,1.51386942266559,-4.8811203945268,0.430733276549047,"G3BP1","G3BP stress granule assembly factor 1",TRUE
+"1557350_at",0.713607328718737,0.188340542367488,1.35733617237378,-5.08009100882082,0.721206075330637,"G3BP1","G3BP stress granule assembly factor 1",TRUE
+"244396_at",0.782471668844017,0.304724240781002,1.05069464704611,-5.41583098079442,0.583334089546699,"G3BP1","G3BP stress granule assembly factor 1",TRUE
+"201514_s_at",0.860085676417428,0.4792194852354,0.719722712315682,-5.69048554465246,0.287410338905234,"G3BP1","G3BP stress granule assembly factor 1",TRUE
+"222187_x_at",0.993083193605528,0.967054735451959,-0.0417718288450763,-5.93883364700078,-0.0118573576980179,"G3BP1","G3BP stress granule assembly factor 1",TRUE
+"208841_s_at",0.937842878751575,0.724730177994367,-0.356646888748698,-5.87791969348882,-0.110155747292595,"G3BP2","G3BP stress granule assembly factor 2",TRUE
+"206383_s_at",0.986342822130003,0.934736292705193,-0.0828226032305086,-5.936342982688,-0.039958158407984,"G3BP2","G3BP stress granule assembly factor 2",TRUE
+"208840_s_at",0.99420041915836,0.973575153294225,0.0335008542074457,-5.93913686105928,0.0146992448145902,"G3BP2","G3BP stress granule assembly factor 2",TRUE
+"206952_at",0.73223722457785,0.216202068358319,-1.27303267622523,-5.17974007472665,-1.0373759433094,"G6PC","glucose-6-phosphatase catalytic subunit",TRUE
+"1555612_s_at",0.980176424909863,0.906892395971745,0.118304485841741,-5.93286886720658,0.0632532422197949,"G6PC","glucose-6-phosphatase catalytic subunit",TRUE
+"221453_at",0.797076936586489,0.330217993783155,0.995549426922287,-5.46814241065058,0.381766355737942,"G6PC2","glucose-6-phosphatase catalytic subunit 2",TRUE
+"44654_at",0.691311047868755,0.161055330621843,-1.45004408033549,-4.96438619036805,-0.565881786851662,"G6PC3","glucose-6-phosphatase catalytic subunit 3",TRUE
+"221759_at",0.774230543658252,0.289967361538173,-1.08412143964089,-5.3828894848839,-0.408673642150312,"G6PC3","glucose-6-phosphatase catalytic subunit 3",TRUE
+"202275_at",0.724970327905974,0.202715552890901,-1.31271128867191,-5.13351115783039,-0.950782476006566,"G6PD","glucose-6-phosphate dehydrogenase",TRUE
+"202812_at",0.822850703882235,0.388417299194237,-0.879787366378114,-5.56955618131087,-0.595461820630227,"GAA","glucosidase alpha, acid",TRUE
+"207112_s_at",0.748067267263424,0.240007848389011,-1.20740497736017,-5.25352868466001,-0.422926037049025,"GAB1","GRB2 associated binding protein 1",TRUE
+"226002_at",0.772392316223901,0.282680754415002,-1.10107888457674,-5.36582637266443,-0.395544542730274,"GAB1","GRB2 associated binding protein 1",TRUE
+"229114_at",0.819018525257656,0.37469611643481,-0.905975451098353,-5.54762323070147,-0.429819452312469,"GAB1","GRB2 associated binding protein 1",TRUE
+"1560382_at",0.84231658612216,0.435986454270821,0.793352721637869,-5.63768525850975,0.222540412995771,"GAB1","GRB2 associated binding protein 1",TRUE
+"225998_at",0.842348838616739,0.436097228679132,-0.79315853670284,-5.63783088645021,-0.273911206738012,"GAB1","GRB2 associated binding protein 1",TRUE
+"214987_at",0.980009054680439,0.905847576948625,0.119638654887483,-5.93271435133341,0.0815722227515598,"GAB1","GRB2 associated binding protein 1",TRUE
+"1557030_at",0.99783553534859,0.989465216784769,-0.0133535766325601,-5.9395966289947,-0.0103741937532114,"GAB1","GRB2 associated binding protein 1",TRUE
+"203853_s_at",0.724521152334098,0.201673295242298,1.31586209028794,-5.12978870282242,1.11075860325118,"GAB2","GRB2 associated binding protein 2",TRUE
+"228410_at",0.870433264908839,0.508796477849795,0.671574921049909,-5.72236734508197,0.352647513162134,"GAB3","GRB2 associated binding protein 3",TRUE
+"241259_at",0.94943075115007,0.771600770510372,0.293859007360362,-5.89771136260155,0.168231625348481,"GAB3","GRB2 associated binding protein 3",TRUE
+"1563816_at",0.832566221132155,0.408783542867722,0.842002112529718,-5.60014801585552,0.440432750879255,"GAB4","GRB2 associated binding protein family member 4",TRUE
+"200645_at",0.721094750464234,0.197360795450251,1.32903560339588,-5.11414360094751,0.361728116164565,"GABARAP","GABA type A receptor-associated protein",TRUE
+"208868_s_at",0.519956259865057,0.0375300356166093,2.21260364025814,-3.80078479816117,2.21411321895166,"GABARAPL1","GABA type A receptor associated protein like 1",TRUE
+"208869_s_at",0.599286814317722,0.075904182700507,1.86210492328354,-4.37870748676351,1.92722042113161,"GABARAPL1","GABA type A receptor associated protein like 1",TRUE
+"209046_s_at",0.851319596585235,0.455299141907292,-0.759943318926272,-5.66224565295048,-0.257536949563038,"GABARAPL2","GABA type A receptor associated protein like 2",TRUE
+"211457_at",0.632216562924782,0.103089593000999,1.70020125963742,-4.62201299597403,1.25409366951601,"GABARAPL3","GABA type A receptor associated protein like 3 pseudogene",TRUE
+"211458_s_at",0.606138724709726,0.0798316661535677,1.83588716630966,-4.41919272004122,2.67503486780454,"GABARAPL3///GABARAPL1","GABA type A receptor associated protein like 3 pseudogene///GABA type A receptor associated protein like 1",TRUE
+"203146_s_at",0.80764044633141,0.349113384702269,-0.956555015120047,-5.50358566251031,-0.756557465948761,"GABBR1","gamma-aminobutyric acid type B receptor subunit 1",TRUE
+"238569_at",0.914242258486146,0.639377783290769,0.475082653293222,-5.83034552533197,0.24965953402662,"GABBR1","gamma-aminobutyric acid type B receptor subunit 1",TRUE
+"211679_x_at",0.808309985919704,0.351236161295672,-0.952265060329707,-5.50740593490645,-0.939625865038353,"GABBR2","gamma-aminobutyric acid type B receptor subunit 2",TRUE
+"209990_s_at",0.869772381052069,0.507403015382474,-0.673807033232122,-5.72093593411973,-0.820476106243792,"GABBR2","gamma-aminobutyric acid type B receptor subunit 2",TRUE
+"209991_x_at",0.954672574687803,0.793613592905996,0.264797037532777,-5.90558943323889,0.152724535710064,"GABBR2","gamma-aminobutyric acid type B receptor subunit 2",TRUE
+"217077_s_at",0.959451355429682,0.816841076891677,-0.234381554059298,-5.912962172052,-0.16664622317224,"GABBR2","gamma-aminobutyric acid type B receptor subunit 2",TRUE
+"210188_at",0.731548533938014,0.214971966866866,1.27657116533216,-5.17566648622659,0.424972396401268,"GABPA","GA binding protein transcription factor alpha subunit",TRUE
+"227428_at",0.888972420461865,0.556487792642484,0.597109149098958,-5.76750257009309,0.196886475656356,"GABPA","GA binding protein transcription factor alpha subunit",TRUE
+"204618_s_at",0.411110107932987,0.0161531508706014,-2.60382099705228,-3.08688779354838,-0.836538841942241,"GABPB1","GA binding protein transcription factor beta subunit 1",TRUE
+"206173_x_at",0.579036829255831,0.0618970900907599,-1.96645032655078,-4.21361377411356,-0.80129663491404,"GABPB1","GA binding protein transcription factor beta subunit 1",TRUE
+"235274_at",0.705378331100654,0.177077201387936,-1.39421650260082,-5.0348180735439,-0.892586971062223,"GABPB1-AS1","GABPB1 antisense RNA 1",TRUE
+"231979_at",0.718239856181288,0.194118525007607,-1.33908888773891,-5.10211593627907,-1.38504098484137,"GABPB1-AS1","GABPB1 antisense RNA 1",TRUE
+"227406_at",0.721868021715132,0.19800815232864,-1.32704385338219,-5.11651746472341,-0.513238151873303,"GABPB1-AS1","GABPB1 antisense RNA 1",TRUE
+"1568983_a_at",0.817915083386752,0.370926389947149,-0.913280596912557,-5.54139901733828,-0.538819778126174,"GABPB1-AS1","GABPB1 antisense RNA 1",TRUE
+"226900_at",0.920147736488699,0.660113525579214,-0.44573527715732,-5.84337438814775,-0.447307773629752,"GABPB1-AS1","GABPB1 antisense RNA 1",TRUE
+"235172_at",0.986342822130003,0.934984997609914,0.0825062345747344,-5.93636845006967,0.0743492635292995,"GABPB1-AS1","GABPB1 antisense RNA 1",TRUE
+"228466_at",0.813442508625161,0.363482477649183,-0.927851897174591,-5.5288462450675,-0.254129631953067,"GABPB2","GA binding protein transcription factor beta subunit 2",TRUE
+"244118_at",0.90466378569832,0.608995823428435,0.518869414099674,-5.80939762035714,0.582560515275756,"GABRA1","gamma-aminobutyric acid type A receptor alpha1 subunit",TRUE
+"206678_at",0.974992501617153,0.878643448370926,-0.154462496371591,-5.92806948264311,-0.0994829222516387,"GABRA1","gamma-aminobutyric acid type A receptor alpha1 subunit",TRUE
+"1554308_s_at",0.817915083386752,0.370914105070654,0.913304483329024,-5.54137858971499,0.826533825040079,"GABRA2","gamma-aminobutyric acid type A receptor alpha2 subunit",TRUE
+"237250_at",0.865854896594418,0.495976343535468,0.692242679789169,-5.70893988394691,0.424699724298362,"GABRA2","gamma-aminobutyric acid type A receptor alpha2 subunit",TRUE
+"207014_at",0.899998627338565,0.594319320885434,0.540389694913013,-5.7984430345799,0.418781276435152,"GABRA2","gamma-aminobutyric acid type A receptor alpha2 subunit",TRUE
+"216039_at",0.996898592071515,0.98416016389721,-0.0200788896044358,-5.93948711740475,-0.0197444764983463,"GABRA2","gamma-aminobutyric acid type A receptor alpha2 subunit",TRUE
+"207210_at",0.579111490485788,0.0621002177789886,1.96479457958058,-4.21628177710726,1.4483947123441,"GABRA3","gamma-aminobutyric acid type A receptor alpha3 subunit",TRUE
+"233437_at",0.597879550155311,0.0752672719389287,1.86646743020991,-4.37193140733533,1.20638049186326,"GABRA4","gamma-aminobutyric acid type A receptor alpha4 subunit",TRUE
+"208463_at",0.998559112870303,0.99388364633359,-0.00775274763366763,-5.93965420581535,-0.00255237452995694,"GABRA4","gamma-aminobutyric acid type A receptor alpha4 subunit",TRUE
+"206456_at",0.690937549779432,0.160636545399417,-1.45156213881143,-4.96243946193682,-1.2013322916793,"GABRA5","gamma-aminobutyric acid type A receptor alpha5 subunit",TRUE
+"217280_x_at",0.870517518639056,0.50962753119606,0.670245332012307,-5.72321782419733,0.345103907113471,"GABRA5","gamma-aminobutyric acid type A receptor alpha5 subunit",TRUE
+"215531_s_at",0.957763250910876,0.810196764844608,-0.243057689801068,-5.91095012622397,-0.197481156988205,"GABRA5","gamma-aminobutyric acid type A receptor alpha5 subunit",TRUE
+"207182_at",0.974894529529979,0.877449653373027,-0.155994831842751,-5.92783804346363,-0.112443731210373,"GABRA6","gamma-aminobutyric acid type A receptor alpha6 subunit",TRUE
+"207010_at",0.455234810916548,0.0221300648877057,2.46056283145048,-3.35562722292077,1.61450773903343,"GABRB1","gamma-aminobutyric acid type A receptor beta1 subunit",TRUE
+"236716_at",0.594972224548427,0.071761571491187,1.8910729844733,-4.33350361896494,0.599790889905221,"GABRB1","gamma-aminobutyric acid type A receptor beta1 subunit",TRUE
+"1556904_at",0.630603891142543,0.101810746360971,1.7069420344691,-4.61220948245517,1.2576646628805,"GABRB1","gamma-aminobutyric acid type A receptor beta1 subunit",TRUE
+"1558226_a_at",0.682504456039784,0.150005646724633,-1.49121605452388,-4.91100427804332,-1.55829915272255,"GABRB1","gamma-aminobutyric acid type A receptor beta1 subunit",TRUE
+"1557256_a_at",0.71865292461294,0.194335317611382,1.33841259213022,-5.10292743918761,1.22334836396426,"GABRB1","gamma-aminobutyric acid type A receptor beta1 subunit",TRUE
+"1558225_at",0.872503767305084,0.515682839331757,0.6605938641415,-5.7293430360243,0.54555970280463,"GABRB1","gamma-aminobutyric acid type A receptor beta1 subunit",TRUE
+"207352_s_at",0.86299627204519,0.486987178443718,-0.706916445857695,-5.69917081623008,-0.42397729611291,"GABRB2","gamma-aminobutyric acid type A receptor beta2 subunit",TRUE
+"242344_at",0.921616670834508,0.665687893271082,-0.437914259614464,-5.84670910414682,-0.46420780292102,"GABRB2","gamma-aminobutyric acid type A receptor beta2 subunit",TRUE
+"1557122_s_at",0.952082954955992,0.780854415308914,-0.28161204808558,-5.9011304187008,-0.201605988345102,"GABRB2","gamma-aminobutyric acid type A receptor beta2 subunit",TRUE
+"1569689_s_at",0.447294524001345,0.0212296166398443,2.47963966311344,-3.32029688791506,1.32337506445319,"GABRB3","gamma-aminobutyric acid type A receptor beta3 subunit",TRUE
+"227690_at",0.712055111306836,0.186170611548144,-1.36430292743403,-5.07161626174332,-1.23977647670319,"GABRB3","gamma-aminobutyric acid type A receptor beta3 subunit",TRUE
+"229724_at",0.735413789306046,0.22043719016188,-1.26096714778137,-5.19355751194879,-1.0364836815314,"GABRB3","gamma-aminobutyric acid type A receptor beta3 subunit",TRUE
+"205850_s_at",0.828607509614823,0.39891190660332,-0.860161717975873,-5.58560155698514,-0.839316982315951,"GABRB3","gamma-aminobutyric acid type A receptor beta3 subunit",TRUE
+"227830_at",0.93919895813272,0.727826385158169,0.352456666225493,-5.87935818576589,0.319676912387909,"GABRB3","gamma-aminobutyric acid type A receptor beta3 subunit",TRUE
+"230255_at",0.723973974120865,0.20094106441215,-1.31808326022978,-5.12716001503297,-0.644773326839335,"GABRD","gamma-aminobutyric acid type A receptor delta subunit",TRUE
+"208457_at",0.870084233343568,0.508274118625591,-0.672411257938545,-5.72183155080024,-0.525395110155634,"GABRD","gamma-aminobutyric acid type A receptor delta subunit",TRUE
+"1552943_at",0.708894565317004,0.181193379553575,1.38052860459092,-5.05173846085302,1.49473804873027,"GABRG1","gamma-aminobutyric acid type A receptor gamma1 subunit",TRUE
+"241805_at",0.888335675282745,0.554415697259682,-0.60027188086013,-5.76568942091897,-0.213054223050689,"GABRG1","gamma-aminobutyric acid type A receptor gamma1 subunit",TRUE
+"1568612_at",0.759462911207093,0.257026791572973,1.16344244892778,-5.30106109244388,0.80890191207768,"GABRG2","gamma-aminobutyric acid type A receptor gamma2 subunit",TRUE
+"206849_at",0.918515815942389,0.653955774833181,0.454407778079603,-5.83960892257728,0.354828770457084,"GABRG2","gamma-aminobutyric acid type A receptor gamma2 subunit",TRUE
+"216895_at",0.71611852101483,0.191814297344747,-1.34631393098221,-5.09342498395878,-0.589541046155164,"GABRG3","gamma-aminobutyric acid type A receptor gamma3 subunit",TRUE
+"1555517_at",0.837512558923881,0.421475227412722,-0.819059802883988,-5.61811080897781,-0.603580703808412,"GABRG3","gamma-aminobutyric acid type A receptor gamma3 subunit",TRUE
+"237621_at",0.831013183269159,0.40501148562502,0.848907627794091,-5.59465056541317,0.589671201161148,"GABRG3-AS1","GABRG3 antisense RNA 1",TRUE
+"205044_at",0.26338132901877,0.0039689927039624,3.21445740867865,-1.86893069529159,3.63786012881177,"GABRP","gamma-aminobutyric acid type A receptor pi subunit",TRUE
+"238123_at",0.314168657577402,0.00670935191667565,2.99037795487328,-2.32739234872367,1.78491900965358,"GABRQ","gamma-aminobutyric acid type A receptor theta subunit",TRUE
+"220886_at",0.975196332002567,0.879414217464596,-0.153473351293615,-5.92821766944067,-0.0733851338649965,"GABRQ","gamma-aminobutyric acid type A receptor theta subunit",TRUE
+"206525_at",0.748184017928985,0.240286589552943,-1.20666640857172,-5.25433989380359,-0.424069965767869,"GABRR1","gamma-aminobutyric acid type A receptor rho1 subunit",TRUE
+"208217_at",0.953983577550391,0.788355129805129,0.271717311645849,-5.90378730541853,0.12552038544616,"GABRR2","gamma-aminobutyric acid type A receptor rho2 subunit",TRUE
+"234410_at",0.769258076576208,0.276074442494311,-1.11672900253067,-5.34987001944486,-0.847004629998961,"GABRR3","gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)",TRUE
+"206669_at",0.60020024844319,0.0765117757620935,-1.85797286613419,-4.38511525904518,-2.15566144563004,"GAD1","glutamate decarboxylase 1",TRUE
+"206670_s_at",0.830635993561085,0.403720528413422,-0.851280413727659,-5.59275193365176,-1.04960087511976,"GAD1","glutamate decarboxylase 1",TRUE
+"205278_at",0.954724542854807,0.794267957133859,0.263936807788492,-5.90581022151401,0.339248757609264,"GAD1","glutamate decarboxylase 1",TRUE
+"211264_at",0.819193107051406,0.37581531446863,-0.903815982297869,-5.54945432681096,-0.609733801619935,"GAD2","glutamate decarboxylase 2",TRUE
+"216651_s_at",0.853297110808539,0.460022796742898,0.751902959188839,-5.66800733644075,0.575990046535802,"GAD2","glutamate decarboxylase 2",TRUE
+"1568601_at",0.906845308365483,0.614893826705342,0.51029109176816,-5.81364340985369,0.325739160545327,"GAD2","glutamate decarboxylase 2",TRUE
+"243265_at",0.943512938262733,0.747570642855695,-0.325883057152353,-5.888089452326,-0.207020324537135,"GAD2","glutamate decarboxylase 2",TRUE
+"206780_at",0.973071267819624,0.870372656745437,0.165086735326811,-5.9264179536681,0.0968149159100475,"GAD2","glutamate decarboxylase 2",TRUE
+"203725_at",0.528056136690037,0.0405659353942693,2.17513753044097,-3.86560731113644,1.6809874339037,"GADD45A","growth arrest and DNA damage inducible alpha",TRUE
+"209304_x_at",0.620754085170559,0.0904042375639431,-1.77049392970896,-4.51836640205115,-0.817566619265273,"GADD45B","growth arrest and DNA damage inducible beta",TRUE
+"207574_s_at",0.683019114815084,0.151955381866356,-1.48377614431284,-4.92073989341024,-0.678524940455087,"GADD45B","growth arrest and DNA damage inducible beta",TRUE
+"213560_at",0.686998148149102,0.15563238452698,1.46995397525475,-4.938722804379,1.01375981601902,"GADD45B","growth arrest and DNA damage inducible beta",TRUE
+"209305_s_at",0.859483694145165,0.476905894496223,-0.723560353807046,-5.68785395144457,-0.328052915561585,"GADD45B","growth arrest and DNA damage inducible beta",TRUE
+"204121_at",0.429960090499345,0.019043418818796,-2.52929006208443,-3.22767457327448,-1.53703300621127,"GADD45G","growth arrest and DNA damage inducible gamma",TRUE
+"225495_x_at",0.828924658834397,0.399809276234511,0.858499121130127,-5.58694537913393,0.253191670843874,"GADD45GIP1","GADD45G interacting protein 1",TRUE
+"212889_x_at",0.829803290928719,0.401543546912139,0.855292742729802,-5.58953015141804,0.562434742655238,"GADD45GIP1","GADD45G interacting protein 1",TRUE
+"212891_s_at",0.954315355006891,0.789737613436005,0.269896627488714,-5.90426591010437,0.0988146024687868,"GADD45GIP1","GADD45G interacting protein 1",TRUE
+"1563533_at",0.824027323790285,0.391306672114812,0.87435011481397,-5.57403519927875,0.606493021767216,"GADL1","glutamate decarboxylase like 1",TRUE
+"1554901_at",0.940227139261806,0.73249623689632,0.3461488835036,-5.88149194964247,0.262181585242147,"GAFA1","FGF2-associated protein GAFA1",TRUE
+"1555645_at",0.993225426079816,0.96809395641837,-0.0404534202469047,-5.93888644349568,-0.0130321726721663,"GAFA2","FGF-2 activity-associated protein 2",TRUE
+"1555726_at",0.971216837324271,0.862379913720706,0.175372308718167,-5.9247147292598,0.128237706566114,"GAFA3","FGF-2 activity-associated protein 3",TRUE
+"208283_at",0.789378278298554,0.315739127537778,-1.02648624126521,-5.43910892024578,-0.958327434840193,"GAGE1","G antigen 1",TRUE
+"208155_x_at",0.861659105448003,0.48313955200068,-0.71324492680876,-5.69489736263003,-0.785174271824387,"GAGE12D///GAGE12F///GAGE12H///GAGE12E///GAGE12B///GAGE12C///GAGE2D///GAGE12J///GAGE12G///GAGE13///GAGE12I///GAGE7///GAGE6///GAGE5///GAGE4///GAGE1","G antigen 12D///G antigen 12F///G antigen 12H///G antigen 12E///G antigen 12B///G antigen 12C///G antigen 2D///G antigen 12J///G antigen 12G///G antigen 13///G antigen 12I///G antigen 7///G antigen 6///G antigen 5///G antigen 4///G antigen 1",TRUE
+"206640_x_at",0.875853785035033,0.523830247291186,-0.647706400571715,-5.73738907841201,-0.951232279534223,"GAGE12D///GAGE12F///GAGE2A///GAGE12H///GAGE12E///GAGE12B///GAGE12C///GAGE12G///GAGE12I///GAGE7///GAGE6///GAGE5///GAGE4///GAGE2C","G antigen 12D///G antigen 12F///G antigen 2A///G antigen 12H///G antigen 12E///G antigen 12B///G antigen 12C///G antigen 12G///G antigen 12I///G antigen 7///G antigen 6///G antigen 5///G antigen 4///G antigen 2C",TRUE
+"207739_s_at",0.959969342594555,0.81891062144895,0.23168292920053,-5.91357316799418,0.329537203531032,"GAGE12D///GAGE8///GAGE12F///GAGE2A///GAGE12H///GAGE12E///GAGE12B///GAGE12C///GAGE2D///GAGE12J///GAGE12G///GAGE13///GAGE2B///GAGE2E///GAGE12I///GAGE7///GAGE6///GAGE5///GAGE4///GAGE3///GAGE2C///GAGE1","G antigen 12D///G antigen 8///G antigen 12F///G antigen 2A///G antigen 12H///G antigen 12E///G antigen 12B///G antigen 12C///G antigen 2D///G antigen 12J///G antigen 12G///G antigen 13///G antigen 2B///G antigen 2E///G antigen 12I///G antigen 7///G antigen 6///G antigen 5///G antigen 4///G antigen 3///G antigen 2C///G antigen 1",TRUE
+"207086_x_at",0.879960488971225,0.535061161750899,-0.630120037366473,-5.74812303560027,-0.700027986352604,"GAGE12D///GAGE8///GAGE12F///GAGE2A///GAGE12H///GAGE12E///GAGE12B///GAGE12C///GAGE2D///GAGE12J///GAGE12G///GAGE13///GAGE2E///GAGE12I///GAGE7///GAGE6///GAGE5///GAGE4///GAGE2C///GAGE1","G antigen 12D///G antigen 8///G antigen 12F///G antigen 2A///G antigen 12H///G antigen 12E///G antigen 12B///G antigen 12C///G antigen 2D///G antigen 12J///G antigen 12G///G antigen 13///G antigen 2E///G antigen 12I///G antigen 7///G antigen 6///G antigen 5///G antigen 4///G antigen 2C///G antigen 1",TRUE
+"208235_x_at",0.7768734672127,0.294371198237522,-1.0740210906665,-5.39294049491039,-1.42072128608665,"GAGE12F///GAGE12B///GAGE12G///GAGE12I///GAGE7///GAGE6///GAGE5///GAGE4","G antigen 12F///G antigen 12B///G antigen 12G///G antigen 12I///G antigen 7///G antigen 6///G antigen 5///G antigen 4",TRUE
+"207663_x_at",0.91539387234353,0.643169190624431,-0.469685699456394,-5.83280255319024,-0.559846443695377,"GAGE3","G antigen 3",TRUE
+"202281_at",0.470295441559609,0.0252314519646263,-2.39995499412964,-3.46689372778809,-0.761373571238146,"GAK","cyclin G associated kinase",TRUE
+"40225_at",0.476902501373111,0.0264291646851491,-2.37838144319768,-3.50613072745609,-0.797493936607125,"GAK","cyclin G associated kinase",TRUE
+"202280_at",0.848376789225697,0.448533047565889,-0.771548223618814,-5.65382750144909,-0.384519096977833,"GAK","cyclin G associated kinase",TRUE
+"214240_at",0.490107603095446,0.029269994593653,2.33061346413059,-3.59229814555617,2.48006852036853,"GAL","galanin and GMAP prepropeptide",TRUE
+"207466_at",0.73957587762701,0.22777817732828,1.24046737240114,-5.21677503123797,0.485776685720531,"GAL","galanin and GMAP prepropeptide",TRUE
+"205670_at",0.796378050779806,0.328823640261746,0.99848716853647,-5.46542002029901,0.609950407905384,"GAL3ST1","galactose-3-O-sulfotransferase 1",TRUE
+"1553046_s_at",0.974560157725574,0.87575838444212,0.158166372332627,-5.92750615703942,0.0947842288744303,"GAL3ST2","galactose-3-O-sulfotransferase 2",TRUE
+"1553257_at",0.94960065125426,0.772070730165712,0.293235936738149,-5.89788879396666,0.144352676315461,"GAL3ST3","galactose-3-O-sulfotransferase 3",TRUE
+"219815_at",0.566031560451315,0.0569396174207999,2.00843064518552,-4.14546231293236,1.54851089593102,"GAL3ST4","galactose-3-O-sulfotransferase 4",TRUE
+"204417_at",0.822010986888098,0.385599891303518,-0.885114606052379,-5.56514280824891,-0.452203131872233,"GALC","galactosylceramidase",TRUE
+"211810_s_at",0.929088231432081,0.687957824540931,-0.406938141138892,-5.85934677213126,-0.160597557866359,"GALC","galactosylceramidase",TRUE
+"1557649_at",0.774360462422895,0.290624173551309,-1.08260805895435,-5.38440082207344,-0.459508874674623,"GALE","UDP-galactose-4-epimerase",TRUE
+"202528_at",0.912722788750542,0.634140187656515,0.482561874234638,-5.82689512389762,0.187500051962418,"GALE","UDP-galactose-4-epimerase",TRUE
+"1557651_x_at",0.986342822130003,0.934926662476651,0.0825804398453611,-5.9363624853584,0.0233358979827596,"GALE","UDP-galactose-4-epimerase",TRUE
+"204374_s_at",0.713330901550199,0.188064463561319,-1.35821902080077,-5.07901906696595,-0.890061151944503,"GALK1","galactokinase 1",TRUE
+"229458_s_at",0.861962516141708,0.484593735919805,-0.710849702447881,-5.69651905966786,-0.461300803608203,"GALK1","galactokinase 1",TRUE
+"216411_s_at",0.70573152022539,0.177893837270298,-1.39148090447773,-5.03821075293574,-0.499735796060557,"GALK2","galactokinase 2",TRUE
+"205219_s_at",0.854184492233394,0.464279363284875,-0.744699857531632,-5.67311975984321,-0.372697842226676,"GALK2","galactokinase 2",TRUE
+"230918_at",0.990918916504081,0.957209124476833,0.0542665740818496,-5.93824924928619,0.0254791970695019,"GALK2","galactokinase 2",TRUE
+"235256_s_at",0.553930058946379,0.0506577530358666,2.06656760319928,-4.04950555090262,2.0477348621123,"GALM","galactose mutarotase",TRUE
+"234974_at",0.653206225743412,0.122511586205145,1.60564462074709,-4.75641363623994,1.04183085327643,"GALM","galactose mutarotase",TRUE
+"236866_at",0.986143546287878,0.931963973929217,-0.0863497653247239,-5.93605245315046,-0.0340929597872037,"GALNS","galactosamine (N-acetyl)-6-sulfatase",TRUE
+"206335_at",0.99381732632978,0.970623711178489,-0.0372443469802436,-5.9390078779099,-0.0175781887632169,"GALNS","galactosamine (N-acetyl)-6-sulfatase",TRUE
+"236746_at",0.497725944448536,0.0305486414609435,-2.31049165850731,-3.62829588284379,-1.37707953516376,"GALNT1","polypeptide N-acetylgalactosaminyltransferase 1",TRUE
+"201722_s_at",0.863835356219448,0.489873772082581,-0.702187587414042,-5.70234039531942,-0.2776607907496,"GALNT1","polypeptide N-acetylgalactosaminyltransferase 1",TRUE
+"1568618_a_at",0.8920930097751,0.56428248102537,-0.585266233096717,-5.77420969329215,-0.239239174170148,"GALNT1","polypeptide N-acetylgalactosaminyltransferase 1",TRUE
+"201724_s_at",0.92777930247318,0.683222220448322,-0.41349023392571,-5.85674962941187,-0.172322808624498,"GALNT1","polypeptide N-acetylgalactosaminyltransferase 1",TRUE
+"201723_s_at",0.930608206400412,0.692905859456366,-0.400111434225585,-5.86200933399297,-0.169993980413564,"GALNT1","polypeptide N-acetylgalactosaminyltransferase 1",TRUE
+"212256_at",0.737123149977386,0.222846237420721,-1.25418309241348,-5.20127711466766,-0.696131073447301,"GALNT10","polypeptide N-acetylgalactosaminyltransferase 10",TRUE
+"207357_s_at",0.817747890324475,0.370194395324169,-0.914704786838545,-5.54018019140335,-0.543793905292782,"GALNT10","polypeptide N-acetylgalactosaminyltransferase 10",TRUE
+"230906_at",0.986342822130003,0.935155016596898,-0.0822899644409287,-5.93638580356226,-0.0606576535999892,"GALNT10","polypeptide N-acetylgalactosaminyltransferase 10",TRUE
+"219013_at",0.328663980090165,0.00779574781822426,-2.92549632811897,-2.45791314438036,-1.18730964105028,"GALNT11","polypeptide N-acetylgalactosaminyltransferase 11",TRUE
+"222773_s_at",0.395836701278754,0.0135746468202591,2.68175153757597,-2.93755110851938,3.41884434390664,"GALNT12","polypeptide N-acetylgalactosaminyltransferase 12",TRUE
+"218885_s_at",0.399312926596283,0.0141421084599627,2.66347169423539,-2.97276856559914,3.49470862689039,"GALNT12","polypeptide N-acetylgalactosaminyltransferase 12",TRUE
+"243779_at",0.896115372949367,0.577289090974716,-0.565689943911967,-5.78501130036935,-0.485141936789891,"GALNT13","polypeptide N-acetylgalactosaminyltransferase 13",TRUE
+"234472_at",0.934776835502861,0.710289890104672,0.376277161085429,-5.8709571902101,0.278910755028393,"GALNT13","polypeptide N-acetylgalactosaminyltransferase 13",TRUE
+"236536_at",0.986889306520757,0.939080303990272,0.0772979570058902,-5.93677371010586,0.0436028234003762,"GALNT13","polypeptide N-acetylgalactosaminyltransferase 13",TRUE
+"219271_at",0.51531387545335,0.0356703746819371,2.23693804854921,-3.75832159061829,2.76833413671674,"GALNT14","polypeptide N-acetylgalactosaminyltransferase 14",TRUE
+"236361_at",0.726480797733202,0.205479513280944,1.30441630039557,-5.14327501937896,0.436321870829887,"GALNT15","polypeptide N-acetylgalactosaminyltransferase 15",TRUE
+"228501_at",0.76029267756668,0.2587785160767,-1.1590418884162,-5.30573408923649,-0.389395030547472,"GALNT15","polypeptide N-acetylgalactosaminyltransferase 15",TRUE
+"239461_at",0.869971289491322,0.508073385760196,0.672732774677912,-5.72162540313884,0.575520700334439,"GALNT15","polypeptide N-acetylgalactosaminyltransferase 15",TRUE
+"230417_at",0.708222957155366,0.180096791472385,1.38415084827378,-5.04727426168692,0.54788761112386,"GALNT16","polypeptide N-acetylgalactosaminyltransferase 16",TRUE
+"230418_s_at",0.819479221404744,0.376668476454252,-0.902172673796072,-5.55084504570692,-0.736206439285932,"GALNT16","polypeptide N-acetylgalactosaminyltransferase 16",TRUE
+"232548_at",0.854184492233394,0.464622807295781,0.744120389085984,-5.6735290127831,0.448574810971548,"GALNT16","polypeptide N-acetylgalactosaminyltransferase 16",TRUE
+"233188_at",0.204856972689509,0.00231927692903166,-3.44004825781294,-1.3974818872714,-1.60586345742401,"GALNT18","polypeptide N-acetylgalactosaminyltransferase 18",TRUE
+"1554079_at",0.914061405748021,0.638915130196107,0.47574220396686,-5.83004337340444,0.197880640730876,"GALNT18","polypeptide N-acetylgalactosaminyltransferase 18",TRUE
+"223991_s_at",0.445869317136885,0.0208743080309406,2.48737494988815,-3.30592998043375,1.19194613041545,"GALNT2","polypeptide N-acetylgalactosaminyltransferase 2",TRUE
+"217788_s_at",0.498206796273596,0.0310901147333121,2.30220271800366,-3.64307217194083,1.23956649408179,"GALNT2","polypeptide N-acetylgalactosaminyltransferase 2",TRUE
+"217787_s_at",0.640067422642767,0.110566353946092,1.66215356776958,-4.67679823254918,0.836610244890487,"GALNT2","polypeptide N-acetylgalactosaminyltransferase 2",TRUE
+"239930_at",0.812302873476553,0.358649192458235,0.937420007620382,-5.52050418272747,0.674036901589946,"GALNT2","polypeptide N-acetylgalactosaminyltransferase 2",TRUE
+"203398_s_at",0.729273475042162,0.21164607702384,1.28621712496231,-5.16451290185252,0.991889375987155,"GALNT3","polypeptide N-acetylgalactosaminyltransferase 3",TRUE
+"203397_s_at",0.812302873476553,0.358700773379608,0.93731744122692,-5.52059402328467,1.05005233356187,"GALNT3","polypeptide N-acetylgalactosaminyltransferase 3",TRUE
+"229555_at",0.446730129062715,0.0210017043010204,2.48458746244448,-3.31110995730061,2.4065500879113,"GALNT5","polypeptide N-acetylgalactosaminyltransferase 5",TRUE
+"232110_at",0.587626678796111,0.0665264212919293,1.9298526094147,-4.27222716701021,1.1965715087963,"GALNT5","polypeptide N-acetylgalactosaminyltransferase 5",TRUE
+"236129_at",0.654038356341937,0.123199653076646,1.60253250302064,-4.76073649643539,1.54762191254857,"GALNT5","polypeptide N-acetylgalactosaminyltransferase 5",TRUE
+"237183_at",0.773107052530371,0.283760609169667,1.09854605592073,-5.36838995549503,0.657758210363665,"GALNT5","polypeptide N-acetylgalactosaminyltransferase 5",TRUE
+"240390_at",0.921797789017863,0.666658289442431,0.436555608043664,-5.8472824973737,0.341128620818652,"GALNT5","polypeptide N-acetylgalactosaminyltransferase 5",TRUE
+"219956_at",0.767965891104819,0.271048864710859,-1.12881815580765,-5.33740780716113,-1.32147551012288,"GALNT6","polypeptide N-acetylgalactosaminyltransferase 6",TRUE
+"228303_at",0.774230543658252,0.290242795124592,-1.08348650479976,-5.38352379174071,-1.30426607942689,"GALNT6","polypeptide N-acetylgalactosaminyltransferase 6",TRUE
+"218313_s_at",0.796867290731448,0.329707029738031,0.996624970354497,-5.4671465552155,0.601144548606895,"GALNT7","polypeptide N-acetylgalactosaminyltransferase 7",TRUE
+"222587_s_at",0.863408882018863,0.48805697133379,0.705162016609132,-5.70034911113259,0.414599759794111,"GALNT7","polypeptide N-acetylgalactosaminyltransferase 7",TRUE
+"220929_at",0.597879550155311,0.0753508544723434,1.8658931025113,-4.37282412513097,0.572586217171817,"GALNT8","polypeptide N-acetylgalactosaminyltransferase 8",TRUE
+"205616_at",0.964843159353411,0.837223165993318,0.207877953828467,-5.91865779379128,0.14754820651163,"GALNT8///KCNA6","polypeptide N-acetylgalactosaminyltransferase 8///potassium voltage-gated channel subfamily A member 6",TRUE
+"229451_at",0.908709061737317,0.62076291397573,0.501793160357946,-5.81778134136876,0.259486276634406,"GALNT9","polypeptide N-acetylgalactosaminyltransferase 9",TRUE
+"233150_at",0.943883417653357,0.74868470154167,0.324390946161593,-5.88855964390194,0.230307640340756,"GALNTL5","polypeptide N-acetylgalactosaminyltransferase-like 5",TRUE
+"1555273_at",0.683017520100356,0.151234674090415,1.4865171568825,-4.91715765763549,0.980485954171357,"GALNTL6","polypeptide N-acetylgalactosaminyltransferase-like 6",TRUE
+"224242_at",0.358427723880268,0.00981778353589079,2.82495537593127,-2.65791236650982,1.04347189626937,"GALP","galanin like peptide",TRUE
+"220821_at",0.813065886130395,0.362660089761264,0.929473876176276,-5.52743764352309,0.468919084469423,"GALR1","galanin receptor 1",TRUE
+"211226_at",0.581128536542197,0.0635882049724151,1.95280945239636,-4.23554846755169,1.16683473494821,"GALR2","galanin receptor 2",TRUE
+"33579_i_at",0.881970070870254,0.539115524312807,0.623820471223988,-5.75189886232949,0.531095113940514,"GALR3","galanin receptor 3",TRUE
+"203179_at",0.860085676417428,0.478898035077297,-0.720255265654979,-5.69012115111343,-0.305125068619198,"GALT","galactose-1-phosphate uridylyltransferase",TRUE
+"232708_at",0.973071267819624,0.870332180966623,0.165138775294707,-5.92640959450967,0.0708887261017637,"GALT","galactose-1-phosphate uridylyltransferase",TRUE
+"242734_x_at",0.978314802155638,0.895587450938639,-0.13275241731091,-5.93110351131029,-0.0966597237322899,"GALT","galactose-1-phosphate uridylyltransferase",TRUE
+"1552473_at",0.981949416086005,0.913690853959953,0.109628533724439,-5.93383144856617,0.0734575374718567,"GAMT","guanidinoacetate N-methyltransferase",TRUE
+"205354_at",0.986421906591669,0.936090723560372,-0.0810997839384412,-5.9364804890015,-0.0774895096165356,"GAMT","guanidinoacetate N-methyltransferase",TRUE
+"1552474_a_at",0.988027606799625,0.942737409887159,-0.072648824052234,-5.93711316072694,-0.0644232054391924,"GAMT","guanidinoacetate N-methyltransferase",TRUE
+"220124_at",0.585892284764425,0.0659242676885367,-1.93448354399733,-4.26485221415846,-0.873726746468268,"GAN","gigaxonin",TRUE
+"228567_at",0.703948341108555,0.1757279382018,-1.39875840530712,-5.02917305901973,-0.75398299991606,"GAN","gigaxonin",TRUE
+"211934_x_at",0.874474734833648,0.520589582729818,-0.652819115703906,-5.73421525416873,-0.21628602336904,"GANAB","glucosidase II alpha subunit",TRUE
+"214626_s_at",0.921312278448293,0.664693847966659,-0.439306891363007,-5.84611955504378,-0.171088204295016,"GANAB","glucosidase II alpha subunit",TRUE
+"236077_at",0.869082033398093,0.505946315650123,0.676144123570225,-5.71943233160118,0.241941222307196,"GANC","glucosidase alpha, neutral C",TRUE
+"235714_at",0.920319799018362,0.660930167507197,0.444587746701045,-5.84386729656096,0.219852832185526,"GANC","glucosidase alpha, neutral C",TRUE
+"235340_at",0.984244246588495,0.923332602779169,-0.0973386745207346,-5.93506969989277,-0.0398604351493184,"GANC","glucosidase alpha, neutral C",TRUE
+"216963_s_at",0.726696341943087,0.206895290977655,1.30020090739236,-5.14821678366486,0.380579878018986,"GAP43","growth associated protein 43",TRUE
+"216967_at",0.737135512363148,0.223222708846266,1.25312799836674,-5.20247450125462,0.980712802071293,"GAP43","growth associated protein 43",TRUE
+"204471_at",0.932633693661011,0.702706177652972,0.386646664839209,-5.86713081768979,0.311160615052314,"GAP43","growth associated protein 43",TRUE
+"AFFX-HUMGAPDH/M33197_M_at",0.949495693037756,0.771793962094368,0.293602860372475,-5.89778435060237,0.0646396778659692,"GAPDH","glyceraldehyde-3-phosphate dehydrogenase",TRUE
+"213453_x_at",0.965914344760007,0.840370740499552,-0.203799070287478,-5.9194739945547,-0.0450708750569095,"GAPDH","glyceraldehyde-3-phosphate dehydrogenase",TRUE
+"AFFX-HUMGAPDH/M33197_3_at",0.974982245454858,0.878514101653593,-0.154628505317741,-5.92804451926226,-0.0340354601301627,"GAPDH","glyceraldehyde-3-phosphate dehydrogenase",TRUE
+"217398_x_at",0.985498770484702,0.929883256699455,0.0889977525099443,-5.93582638475885,0.0206627446495453,"GAPDH","glyceraldehyde-3-phosphate dehydrogenase",TRUE
+"AFFX-HUMGAPDH/M33197_5_at",0.992816117752561,0.965995467669345,-0.0431157479633489,-5.93877808667202,-0.00927543618403881,"GAPDH","glyceraldehyde-3-phosphate dehydrogenase",TRUE
+"212581_x_at",0.99709957716848,0.985268886789149,0.0186732733675298,-5.93951364757885,0.00428923286319183,"GAPDH","glyceraldehyde-3-phosphate dehydrogenase",TRUE
+"238807_at",0.841550580403629,0.433234004224012,-0.798187508569694,-5.63404862611623,-0.326584871882922,"GAPDHP62///ANKRD46","glyceraldehyde 3 phosphate dehydrogenase pseudogene 62///ankyrin repeat domain 46",TRUE
+"207116_s_at",0.733219916295619,0.21765266102383,1.26887977238767,-5.184508673953,0.75145541368691,"GAPDHS","glyceraldehyde-3-phosphate dehydrogenase, spermatogenic",TRUE
+"242465_at",0.89967769475675,0.590917739377373,0.545414160054141,-5.79582307326861,0.273052246908081,"GAPLINC","gastric adenocarcinoma associated, positive CD44 regulator, long intergenic non-coding RNA",TRUE
+"1552386_at",0.899808883319249,0.591850380399778,-0.544035150853782,-5.7965444912926,-0.288914210820313,"GAPT","GRB2-binding adaptor protein, transmembrane",TRUE
+"212804_s_at",0.725991386434717,0.205083437832358,-1.30559962703245,-5.14188535325114,-0.381780974215665,"GAPVD1","GTPase activating protein and VPS9 domains 1",TRUE
+"212802_s_at",0.765934384067577,0.266312149902181,-1.14036363678011,-5.32539543909249,-0.347326069632507,"GAPVD1","GTPase activating protein and VPS9 domains 1",TRUE
+"214869_x_at",0.871451481476429,0.512274620173097,-0.666018357233619,-5.72591090912798,-0.189015633932959,"GAPVD1","GTPase activating protein and VPS9 domains 1",TRUE
+"235553_at",0.957430653957785,0.807690437535352,-0.246335372942419,-5.91017108902295,-0.227005745130749,"GAPVD1","GTPase activating protein and VPS9 domains 1",TRUE
+"219110_at",0.981508003489034,0.912214525785007,-0.111511815607188,-5.9336287210468,-0.0473708905703436,"GAR1","GAR1 ribonucleoprotein",TRUE
+"237262_at",0.758920166935337,0.256205196390051,1.16551406852169,-5.29885584598269,0.35411527341832,"GAREM1","GRB2 associated regulator of MAPK1 subtype 1",TRUE
+"228115_at",0.893600768892136,0.5688966440657,-0.578295379766813,-5.77809679314181,-0.336573299632925,"GAREM1","GRB2 associated regulator of MAPK1 subtype 1",TRUE
+"235065_at",0.929088231432081,0.687405125028347,-0.40770190680704,-5.85904612961981,-0.181307904633845,"GAREM1","GRB2 associated regulator of MAPK1 subtype 1",TRUE
+"219377_at",0.955730092376044,0.797547512610853,-0.259628541119169,-5.90690525197225,-0.132515187126119,"GAREM1","GRB2 associated regulator of MAPK1 subtype 1",TRUE
+"228028_at",0.54613142770476,0.047324333162515,2.10008930765374,-3.99336677326113,1.33422515389737,"GAREM2","GRB2 associated regulator of MAPK1 subtype 2",TRUE
+"232015_at",0.917601067333473,0.650617546719425,0.459124090471291,-5.83753131581046,0.469023809335626,"GAREM2","GRB2 associated regulator of MAPK1 subtype 2",TRUE
+"216165_at",0.739164893329329,0.225798482823712,1.24594541062428,-5.21060275275095,0.818011536186162,"GARNL3","GTPase activating Rap/RanGAP domain like 3",TRUE
+"1563907_at",0.842224301155785,0.435772247965702,-0.79372830652115,-5.63740349548405,-0.5847456257782,"GARNL3","GTPase activating Rap/RanGAP domain like 3",TRUE
+"223604_at",0.994562347319878,0.974880290441961,-0.0318456294123657,-5.93918954061475,-0.0150810699828074,"GARNL3","GTPase activating Rap/RanGAP domain like 3",TRUE
+"208693_s_at",0.97304633500821,0.869165468035451,0.166639026867165,-5.92616747992616,0.0508384663196537,"GARS","glycyl-tRNA synthetase",TRUE
+"212379_at",0.597654932724127,0.0746359505307062,1.87082354591798,-4.36515407109802,0.596619761740882,"GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase",TRUE
+"210005_at",0.611964994975857,0.0836885481199362,1.81120901541427,-4.45692459065489,0.7782741867151,"GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase",TRUE
+"212378_at",0.632949074657601,0.104051433245372,1.69517807859819,-4.62929954707357,0.588007237605135,"GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase",TRUE
+"217445_s_at",0.689848451630875,0.158890676482249,1.45792541110504,-4.95426130973924,0.517178360369446,"GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase",TRUE
+"230097_at",0.722192678020526,0.198594730938063,1.3252434936805,-5.11866064056569,0.725459682762288,"GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase",TRUE
+"244822_at",0.75959865506602,0.257447073200267,1.16238462428557,-5.30218582420346,0.575195692396443,"GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase",TRUE
+"230766_at",0.816800680706682,0.368519993915549,-0.917969597651583,-5.53737954939401,-0.571679202919627,"GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase",TRUE
+"236969_at",0.839466826665106,0.425648748075798,0.811610584017284,-5.62384324274097,0.495097012774941,"GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase",TRUE
+"216990_at",0.918409982899324,0.653674370279893,0.454804946611423,-5.83943477462416,0.335798152274524,"GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase",TRUE
+"204457_s_at",0.92265243752289,0.669483417501345,-0.43260488503311,-5.84893988526602,-0.653324617834942,"GAS1","growth arrest specific 1",TRUE
+"204456_s_at",0.946249475978621,0.756307308646835,0.314201559392194,-5.89171339275333,0.199685346199144,"GAS1","growth arrest specific 1",TRUE
+"228187_at",0.94895689004559,0.767884625086866,0.298790065429914,-5.89629397634602,0.184605018454747,"GAS1","growth arrest specific 1",TRUE
+"238463_at",0.85334340854827,0.460210904181187,-0.751583799181546,-5.66823484800787,-0.457008057033202,"GAS1RR","GAS1 adjacent regulatory RNA",TRUE
+"1556936_at",0.89390639630277,0.56988438012046,0.576806919834097,-5.77892094909527,0.642730633925909,"GAS1RR","GAS1 adjacent regulatory RNA",TRUE
+"205848_at",0.991215113882097,0.958818197402768,0.0522240006154201,-5.93835517825612,0.0662137921982087,"GAS2","growth arrest specific 2",TRUE
+"208258_s_at",0.271305453183858,0.0042669584474262,-3.183798716807,-1.93229706844105,-2.33437436407684,"GAS2L1","growth arrest specific 2 like 1",TRUE
+"31874_at",0.580137756009815,0.062694952204033,-1.95997412020677,-4.22404056263251,-0.825741647489469,"GAS2L1","growth arrest specific 2 like 1",TRUE
+"209729_at",0.627938764248877,0.0993446787517656,-1.72014664775675,-4.59292105241754,-0.746948221109525,"GAS2L1","growth arrest specific 2 like 1",TRUE
+"1552596_at",0.908229256258766,0.618825139156979,0.504594721842149,-5.8164246569966,0.327095165672143,"GAS2L2","growth arrest specific 2 like 2",TRUE
+"235709_at",0.962555471240652,0.82957520492379,0.217804004076457,-5.91660427305943,0.076001817859094,"GAS2L3","growth arrest specific 2 like 3",TRUE
+"238756_at",0.989942999001074,0.950960881454675,0.0622004821240265,-5.93779925789315,0.0228842509990237,"GAS2L3","growth arrest specific 2 like 3",TRUE
+"1560402_at",0.812302873476553,0.358415378822389,-0.937885060123854,-5.52009671795195,-0.350893532481655,"GAS5","growth arrest specific 5 (non-protein coding)",TRUE
+"235712_at",0.308621629697291,0.00633547755088679,-3.01506110846629,-2.27745653054549,-2.06268759690649,"GAS5-AS1","GAS5 antisense RNA 1",TRUE
+"1598_g_at",0.330171916405281,0.00797090168263013,2.91585516397956,-2.47721347746001,2.05375240539595,"GAS6","growth arrest specific 6",TRUE
+"202177_at",0.449589282893031,0.021470098173456,2.47447228680829,-3.32988118415434,3.43884768792717,"GAS6","growth arrest specific 6",TRUE
+"238127_at",0.784789297644843,0.309219132377799,1.04074240212146,-5.42545984007315,0.641108272289354,"GAS6-AS1","GAS6 antisense RNA 1",TRUE
+"238097_at",0.9330573785522,0.704423996427496,-0.384294081890052,-5.86800792073028,-0.234883648117934,"GAS6-AS1","GAS6 antisense RNA 1",TRUE
+"211067_s_at",0.801560848966415,0.33853558444524,-0.978200794257073,-5.48407051560448,-0.97146978845794,"GAS7","growth arrest specific 7",TRUE
+"207704_s_at",0.839519981963042,0.426546921217829,-0.810013429070273,-5.62506591307023,-0.823160283142785,"GAS7","growth arrest specific 7",TRUE
+"202191_s_at",0.852952502038207,0.45907331097354,0.7535151352715,-5.66685670747428,0.904920292678844,"GAS7","growth arrest specific 7",TRUE
+"202192_s_at",0.974982245454858,0.878345142797721,0.154845360828993,-5.92801186959542,0.111511782305629,"GAS7","growth arrest specific 7",TRUE
+"210872_x_at",0.984161165881616,0.922439175318477,0.0984768071256293,-5.934961201196,0.0859215256518491,"GAS7","growth arrest specific 7",TRUE
+"204921_at",0.915569510513076,0.644147262194496,-0.468295744579587,-5.83343089704862,-0.208182048923385,"GAS8","growth arrest specific 8",TRUE
+"207615_s_at",0.888889248007057,0.556191862159478,0.597560464411423,-5.767244403423,0.438212287608661,"GAS8-AS1","GAS8 antisense RNA 1",TRUE
+"208138_at",0.955730092376044,0.797606167611299,-0.259551533505441,-5.90692466209876,-0.0702013592766191,"GAST","gastrin",TRUE
+"1555590_a_at",0.860567464069796,0.480062374231692,0.71832726890179,-5.69143914482802,0.301235478312648,"GATA1","GATA binding protein 1",TRUE
+"210446_at",0.901910595357431,0.600120070418797,0.53185368622583,-5.8028399986567,0.283011010590291,"GATA1","GATA binding protein 1",TRUE
+"209710_at",0.848804739090129,0.449267365939824,-0.770283652314064,-5.65475066640624,-0.519229308834529,"GATA2","GATA binding protein 2",TRUE
+"210358_x_at",0.856528422017685,0.470437489593952,-0.73434801727958,-5.68038529034094,-0.374639965145208,"GATA2","GATA binding protein 2",TRUE
+"207954_at",0.943464796017993,0.747005839998393,0.32663981224923,-5.88785016860171,0.121387227657463,"GATA2","GATA binding protein 2",TRUE
+"1568639_a_at",0.952293443370532,0.781620155681413,-0.280600604297973,-5.90140633431209,-0.308877462578012,"GATA2-AS1","GATA2 antisense RNA 1",TRUE
+"209603_at",0.869441836317963,0.506647828808694,-0.675018163189803,-5.72015735719733,-0.911789522062588,"GATA3","GATA binding protein 3",TRUE
+"209602_s_at",0.968066640321622,0.849595207271706,-0.191865326791851,-5.92176945394226,-0.318431497981029,"GATA3","GATA binding protein 3",TRUE
+"209604_s_at",0.97689149311934,0.889677907250175,-0.140316258673969,-5.93009841150297,-0.151330581175845,"GATA3","GATA binding protein 3",TRUE
+"240192_at",0.643688366500038,0.114493415028227,-1.64303303888095,-4.70397372131838,-2.90949179545022,"GATA3-AS1","GATA3 antisense RNA 1",TRUE
+"240827_at",0.663325052838397,0.131385299930817,-1.56657715518337,-4.81020512546141,-2.09610714056565,"GATA3-AS1","GATA3 antisense RNA 1",TRUE
+"230855_at",0.465587820359936,0.0240223729535506,2.42271573744465,-3.42528573938575,1.34589720984683,"GATA4","GATA binding protein 4",TRUE
+"205517_at",0.832605695407954,0.409208497496297,-0.841226695164521,-5.60076270475384,-1.27910088443401,"GATA4","GATA binding protein 4",TRUE
+"1570276_a_at",0.848937021892,0.449521275186014,0.769846686294027,-5.65506932885275,0.629296169969848,"GATA4","GATA binding protein 4",TRUE
+"1553131_a_at",0.947062793209778,0.759765959483342,-0.309589504475551,-5.89310811155987,-0.358213931973292,"GATA4","GATA binding protein 4",TRUE
+"243692_at",0.974536463688956,0.875633815117966,0.158326346409969,-5.92748152645716,0.107774141531852,"GATA4","GATA binding protein 4",TRUE
+"238197_at",0.790887605610217,0.320963837763927,-1.01521072989945,-5.4497838662501,-1.61908346014352,"GATA5","GATA binding protein 5",TRUE
+"238095_at",0.976371465776674,0.886042860231808,0.144973027098547,-5.92945196959495,0.157829591974577,"GATA5","GATA binding protein 5",TRUE
+"229282_at",0.861656789622847,0.482313308968892,0.714607717282753,-5.69397236148643,0.430276231800173,"GATA6","GATA binding protein 6",TRUE
+"210002_at",0.908501701461088,0.61955911185511,0.5035330915926,-5.8169396294913,0.320121949709055,"GATA6","GATA binding protein 6",TRUE
+"236118_at",0.904381089098038,0.607251143934133,0.52141450078602,-5.80812467817171,0.250146743958106,"GATA6-AS1","GATA6 antisense RNA 1 (head to head)",TRUE
+"242634_at",0.856069962162874,0.469472368458923,0.735965067032575,-5.67925670855265,0.557013089217052,"GATAD1","GATA zinc finger domain containing 1",TRUE
+"213018_at",0.904381089098038,0.60747402741446,-0.521089170975737,-5.80828773229408,-0.17065154814293,"GATAD1","GATA zinc finger domain containing 1",TRUE
+"208503_s_at",0.906970705662734,0.615396419545974,0.509561897390148,-5.81400113786342,0.189451876495021,"GATAD1","GATA zinc finger domain containing 1",TRUE
+"214718_at",0.984132887597385,0.922109808161498,0.0988964197770376,-5.9349208814072,0.0331862072619149,"GATAD1","GATA zinc finger domain containing 1",TRUE
+"218131_s_at",0.787650949488817,0.313418089749953,-1.0315372977724,-5.43429237283311,-0.344722732562282,"GATAD2A","GATA zinc finger domain containing 2A",TRUE
+"229166_s_at",0.834747247306943,0.413298676260136,-0.833789333692211,-5.60663157392544,-0.299557819154948,"GATAD2A","GATA zinc finger domain containing 2A",TRUE
+"222526_at",0.863318594825537,0.487532234729461,-0.706022291830573,-5.69977168901821,-0.310394490115614,"GATAD2A","GATA zinc finger domain containing 2A",TRUE
+"234294_x_at",0.904832003218088,0.610127333875438,-0.517220654590857,-5.81021901925389,-0.169985614834076,"GATAD2A","GATA zinc finger domain containing 2A",TRUE
+"236932_s_at",0.925091998149497,0.675687729407093,-0.423953028952131,-5.85251776911669,-0.284958286702532,"GATAD2A","GATA zinc finger domain containing 2A",TRUE
+"238324_at",0.937842878751575,0.724810872251165,0.356537599644498,-5.87795742545341,0.252235960458047,"GATAD2A","GATA zinc finger domain containing 2A",TRUE
+"225393_at",0.828052181486662,0.397737656885281,-0.862340942067411,-5.58383649742753,-0.280033119052382,"GATAD2B","GATA zinc finger domain containing 2B",TRUE
+"238076_at",0.942502815705589,0.741780424606898,0.333650422833725,-5.88560732280744,0.279399230350137,"GATAD2B","GATA zinc finger domain containing 2B",TRUE
+"204300_at",0.720174137377026,0.196193928694236,-1.33263869683852,-5.10984165028115,-0.653857506751047,"GATB","glutamyl-tRNA amidotransferase subunit B",TRUE
+"233593_at",0.997056683282451,0.985103065084556,-0.0188834962148503,-5.93950980213904,-0.0145426615730484,"GATB","glutamyl-tRNA amidotransferase subunit B",TRUE
+"225430_at",0.723649742218726,0.200174646805412,-1.32041490373915,-5.12439656013147,-0.498925842684713,"GATC","glutamyl-tRNA amidotransferase subunit C",TRUE
+"214711_at",0.981508003489034,0.912181203322222,-0.111554328235383,-5.93362410493259,-0.0575947304224496,"GATC","glutamyl-tRNA amidotransferase subunit C",TRUE
+"201698_s_at",0.699521299850331,0.171045272203001,-1.41474024491287,-5.00918932377222,-0.422041258860261,"GATC///SRSF9","glutamyl-tRNA amidotransferase subunit C///serine and arginine rich splicing factor 9",TRUE
+"200044_at",0.717937808890208,0.193729417950468,-1.34030421453126,-5.10065677262087,-0.413727542563542,"GATC///SRSF9","glutamyl-tRNA amidotransferase subunit C///serine and arginine rich splicing factor 9",TRUE
+"1557692_a_at",0.498703893437511,0.0313289341766921,2.29858882827541,-3.64950480537195,0.88780407988801,"GATM","glycine amidinotransferase",TRUE
+"216733_s_at",0.517654151778308,0.0367970239500446,2.22206149562391,-3.78431436866283,2.14406662596097,"GATM","glycine amidinotransferase",TRUE
+"203178_at",0.528937808612037,0.0412218381800803,2.16737816660689,-3.87894683021093,2.97283273445729,"GATM","glycine amidinotransferase",TRUE
+"1566861_at",0.630603891142543,0.101707838203827,1.70748758558011,-4.61141478171432,1.20392533996215,"GATM","glycine amidinotransferase",TRUE
+"1566860_at",0.677013732819214,0.14414704082207,1.51405670300489,-4.88087183574862,1.30578468261779,"GATM","glycine amidinotransferase",TRUE
+"235426_at",0.861357981297227,0.481836696414847,0.715394450404346,-5.6934375971203,0.438071857784472,"GATM","glycine amidinotransferase",TRUE
+"231590_at",0.885029460971826,0.545774377667702,0.613528858337111,-5.75798879824449,0.297198070114593,"GATM","glycine amidinotransferase",TRUE
+"231686_at",0.940193511330624,0.731952279866638,0.346882889978653,-5.8812456117472,0.166467075473157,"GATM","glycine amidinotransferase",TRUE
+"1553971_a_at",0.597654932724127,0.075078417853618,1.86776717052845,-4.36991041267225,1.5165970206018,"GATS","GATS, stromal antigen 3 opposite strand",TRUE
+"227321_at",0.627021415091472,0.0975882865452364,1.72972271430658,-4.57886358866647,0.801932474602469,"GATS","GATS, stromal antigen 3 opposite strand",TRUE
+"225906_at",0.922840631846062,0.669677638941461,-0.432333538998426,-5.84905317599294,-0.234616110839069,"GATSL2","GATS protein like 2",TRUE
+"226613_at",0.643515428391208,0.114158677289149,-1.64464113668798,-4.70169743831004,-0.873002802790208,"GATSL3","GATS protein like 3",TRUE
+"233528_s_at",0.748438284778152,0.241006117947326,-1.20476288188669,-5.25642865175281,-0.558952380494425,"GATSL3","GATS protein like 3",TRUE
+"223921_s_at",0.60998004334651,0.0820618077857702,-1.82149490877937,-4.44124251291033,-0.569589304005596,"GBA2","glucosylceramidase beta 2",TRUE
+"224627_at",0.789824589976275,0.318639055905815,-1.02021188233965,-5.44506224058216,-0.540826223695307,"GBA2","glucosylceramidase beta 2",TRUE
+"222943_at",0.68270002258037,0.15054889245937,-1.48913522923971,-4.91373112300545,-1.4538511353695,"GBA3","glucosylceramidase beta 3 (gene/pseudogene)",TRUE
+"219954_s_at",0.798535466562538,0.333084588027897,0.989536684632219,-5.47369166165953,0.574747466721802,"GBA3","glucosylceramidase beta 3 (gene/pseudogene)",TRUE
+"210589_s_at",0.821424121108148,0.383478518998555,-0.889142553467273,-5.56178944555361,-0.462321277915818,"GBAP1","glucosylceramidase beta pseudogene 1",TRUE
+"209093_s_at",0.919095054289206,0.655545493042819,-0.452165473974836,-5.84058931577548,-0.222358235081698,"GBAP1///GBA","glucosylceramidase beta pseudogene 1///glucosylceramidase beta",TRUE
+"201816_s_at",0.848937021892,0.44949486090208,0.769892137075958,-5.65503619130855,0.347580261165334,"GBAS","glioblastoma amplified sequence",TRUE
+"230787_at",0.908667507590078,0.620223504869393,0.502572607982314,-5.81740462612482,0.18322623777003,"GBAT2","glioblastoma multiforme-associated transcript 2",TRUE
+"203282_at",0.861981304384929,0.484674393016733,0.710716972058393,-5.69660877344891,0.47809699333472,"GBE1","glucan (1,4-alpha-), branching enzyme 1",TRUE
+"201439_at",0.940227139261806,0.732953714308357,-0.345531721233369,-5.88169867459335,-0.120612285006565,"GBF1","golgi brefeldin A resistant guanine nucleotide exchange factor 1",TRUE
+"231780_at",0.0407133862811871,4.46786132029488e-05,5.05980867554302,2.07763954497897,2.71524036575243,"GBGT1","globoside alpha-1,3-N-acetylgalactosaminyltransferase 1",TRUE
+"202269_x_at",0.548504186940293,0.0483950942434383,2.08909668445907,-4.01184035224467,2.68103299233268,"GBP1","guanylate binding protein 1",TRUE
+"202270_at",0.562643595171948,0.0552501026028388,2.02348134106695,-4.12079434763153,3.50908909404803,"GBP1","guanylate binding protein 1",TRUE
+"231577_s_at",0.571736836402345,0.0597913470126574,1.98390404651832,-4.18539697998247,3.50608945561897,"GBP1","guanylate binding protein 1",TRUE
+"231578_at",0.891918115867831,0.562034839432911,0.588672471069346,-5.77229391240577,0.45646989339329,"GBP1","guanylate binding protein 1",TRUE
+"1570541_s_at",0.947062793209778,0.75983790123175,-0.309493644385151,-5.89313688358702,-0.151823218771169,"GBP1P1","guanylate binding protein 1 pseudogene 1",TRUE
+"242907_at",0.856690614892852,0.470878214151989,0.73361023952708,-5.68089942218492,0.542078706409318,"GBP2","guanylate binding protein 2",TRUE
+"202748_at",0.868397087637799,0.504253676033708,0.678864509116404,-5.71767585741631,0.48103547351474,"GBP2","guanylate binding protein 2",TRUE
+"223434_at",0.591331966259927,0.0689020440101492,1.91193491949914,-4.30064666956175,3.03411804595606,"GBP3","guanylate binding protein 3",TRUE
+"235574_at",0.448873991611994,0.021406404244489,2.47583565670145,-3.32735347423941,2.24716211681459,"GBP4","guanylate binding protein 4",TRUE
+"235175_at",0.526253358601247,0.0396300308859969,2.18640840801726,-3.84617844274001,1.68488257532529,"GBP4","guanylate binding protein 4",TRUE
+"229625_at",0.189644672791897,0.00191422589990836,3.51993294640678,-1.22865575170278,2.32005708182976,"GBP5","guanylate binding protein 5",TRUE
+"238581_at",0.380084968057051,0.0117476660033991,2.74594052977185,-2.81300898717277,2.10582048476425,"GBP5","guanylate binding protein 5",TRUE
+"1559606_at",0.296090407530139,0.00534912688620092,3.08759715383793,-2.12986300557938,2.91616148772789,"GBP6","guanylate binding protein family member 6",TRUE
+"1559607_s_at",0.622917527985155,0.0938968665573848,1.75033862464145,-4.54840334884656,1.03779607379046,"GBP6","guanylate binding protein family member 6",TRUE
+"217011_at",0.788413816943444,0.314674198695216,1.0288004953998,-5.43690475970195,0.372747435152181,"GBX1","gastrulation brain homeobox 1",TRUE
+"210560_at",0.947926063538122,0.762720262740356,0.305655412305611,-5.89428165946341,0.30960703466471,"GBX2","gastrulation brain homeobox 2",TRUE
+"204965_at",0.728385463227073,0.208823103834912,1.294496785263,-5.15488220289125,0.897983763114566,"GC","GC, vitamin D binding protein",TRUE
+"203765_at",0.894538680437601,0.571025060208942,-0.575089617703507,-5.77986925869144,-0.380335988163239,"GCA","grancalcin",TRUE
+"36475_at",0.901788521024914,0.599528972526688,-0.53272166960591,-5.80239600414714,-0.222553636504065,"GCAT","glycine C-acetyltransferase",TRUE
+"205164_at",0.91876780831279,0.654581123228867,-0.453525439921686,-5.83999527092844,-0.452582425902417,"GCAT","glycine C-acetyltransferase",TRUE
+"243306_s_at",0.634202341398092,0.105380591999739,1.68830105831087,-4.63924890754381,1.45835303726096,"GCC1","GRIP and coiled-coil domain containing 1",TRUE
+"243437_at",0.731965025847759,0.215635180253421,1.27466144637554,-5.17786619640461,0.91132692976997,"GCC1","GRIP and coiled-coil domain containing 1",TRUE
+"218912_at",0.915353407558177,0.643038853121007,0.469870995262623,-5.83271865053924,0.128792079887143,"GCC1","GRIP and coiled-coil domain containing 1",TRUE
+"202832_at",0.657015752622694,0.125783808933056,-1.59097234434289,-4.77673691353433,-0.50392712233162,"GCC2","GRIP and coiled-coil domain containing 2",TRUE
+"237565_at",0.965719307845066,0.839888775625802,-0.204423408599177,-5.91935010609789,-0.149347383863746,"GCC2","GRIP and coiled-coil domain containing 2",TRUE
+"224141_at",0.990980060324272,0.957641668975935,0.0537174748325677,-5.93827812513067,0.014155591535979,"GCC2-AS1","GCC2 antisense RNA 1",TRUE
+"208369_s_at",0.720654489001931,0.196725087251337,1.330996492563,-5.1118035920763,0.554620696924319,"GCDH","glutaryl-CoA dehydrogenase",TRUE
+"203500_at",0.821187434813103,0.382578730637017,0.890855426141006,-5.56035916411602,0.355435136041663,"GCDH","glutaryl-CoA dehydrogenase",TRUE
+"210175_at",0.878110025868144,0.529991282835774,-0.638033815884897,-5.74332795709362,-0.242283930792599,"GCFC2","GC-rich sequence DNA-binding factor 2",TRUE
+"216305_s_at",0.961212424803935,0.823936007483589,0.225137247108544,-5.91502592957876,0.0793438308187326,"GCFC2","GC-rich sequence DNA-binding factor 2",TRUE
+"206422_at",0.95970955193902,0.818179819569851,-0.232635671269841,-5.91335826140124,-0.135681893607282,"GCG","glucagon",TRUE
+"210565_at",0.89961817630669,0.590519629020699,0.546003134418275,-5.79551441504882,0.369713751098932,"GCGR","glucagon receptor",TRUE
+"204224_s_at",0.674515264001574,0.140948091288852,-1.5268508410987,-4.86383341065171,-0.997194135988353,"GCH1","GTP cyclohydrolase 1",TRUE
+"204867_at",0.499515085498997,0.031617027322141,-2.29426275840215,-3.6571973500325,-1.57800510917628,"GCHFR","GTP cyclohydrolase I feedback regulator",TRUE
+"211167_s_at",0.784708646973769,0.308685246203036,-1.04191911340176,-5.42432566187525,-0.698661426473234,"GCK","glucokinase",TRUE
+"206867_at",0.979588787486838,0.902686664175904,-0.123676309376988,-5.93223619113157,-0.0636143363851369,"GCKR","glucokinase (hexokinase 4) regulator",TRUE
+"202922_at",0.597654932724127,0.0749582365192647,1.86859577387586,-4.36862148019546,0.801226646301211,"GCLC","glutamate-cysteine ligase catalytic subunit",TRUE
+"1555330_at",0.70916118893503,0.181964755136098,1.37799100681792,-5.05486011489128,0.62257094588279,"GCLC","glutamate-cysteine ligase catalytic subunit",TRUE
+"202923_s_at",0.774230543658252,0.287797142787233,1.08913952045812,-5.37786470999797,0.515871804088691,"GCLC","glutamate-cysteine ligase catalytic subunit",TRUE
+"203925_at",0.628680114171121,0.0997368844353455,1.71802803527165,-4.59602326594976,1.01087635791367,"GCLM","glutamate-cysteine ligase modifier subunit",TRUE
+"236140_at",0.828607509614823,0.398868780753648,0.860241679722786,-5.58553686554324,0.694820165627139,"GCLM","glutamate-cysteine ligase modifier subunit",TRUE
+"234986_at",0.837337084923913,0.419953219316974,0.821787892301309,-5.6159991693745,0.597705827970003,"GCLM","glutamate-cysteine ligase modifier subunit",TRUE
+"206269_at",0.823074246722209,0.389152736388502,0.878400925248519,-5.57070073086349,0.580828868760295,"GCM1","glial cells missing homolog 1",TRUE
+"220799_at",0.926430328514448,0.680207570273826,0.417670839793665,-5.85507118269037,0.347968533858899,"GCM2","glial cells missing homolog 2",TRUE
+"216232_s_at",0.7717895132349,0.28173107201057,1.10331218940383,-5.36356159757424,0.310104748122241,"GCN1","GCN1, eIF2 alpha kinase activator homolog",TRUE
+"212139_at",0.953844019807428,0.786829208063377,0.273727989100966,-5.90325504474187,0.0852718297228439,"GCN1","GCN1, eIF2 alpha kinase activator homolog",TRUE
+"239761_at",0.943294768503521,0.74519325073855,-0.329069739969517,-5.88707811902745,-0.229027485729912,"GCNT1","glucosaminyl (N-acetyl) transferase 1, core 2",TRUE
+"205505_at",0.94895689004559,0.768780588147604,-0.297600499438022,-5.89663804627623,-0.28323640982496,"GCNT1","glucosaminyl (N-acetyl) transferase 1, core 2",TRUE
+"217195_at",0.71454754703986,0.1896772679999,-1.35307594114989,-5.08525553367085,-0.722950990916624,"GCNT1P1","glucosaminyl (N-acetyl) transferase 1, core 2 pseudogene 1",TRUE
+"211020_at",0.514490373584066,0.0347302048202959,2.24968366258388,-3.73596917295684,2.34913346351158,"GCNT2","glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)",TRUE
+"230788_at",0.61760967235709,0.0879144931518985,1.78527441414868,-4.49617928586305,3.03028823856035,"GCNT2","glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)",TRUE
+"219508_at",0.75017710842651,0.243116381969992,1.199204682779,-5.26251132329587,1.03770792420351,"GCNT3","glucosaminyl (N-acetyl) transferase 3, mucin type",TRUE
+"220831_at",0.930083070178974,0.691494393971301,0.402056819687823,-5.86125510986898,0.242530776380599,"GCNT4","glucosaminyl (N-acetyl) transferase 4, core 2",TRUE
+"234540_at",0.73759219552868,0.224148147195541,1.2505401467456,-5.20540769458555,1.02912584722432,"GCNT7","glucosaminyl (N-acetyl) transferase family member 7",TRUE
+"242040_at",0.929024902913511,0.687164080452223,-0.408035079287299,-5.85891480852749,-0.129954300777904,"GCNT7","glucosaminyl (N-acetyl) transferase family member 7",TRUE
+"212243_at",0.609827382478528,0.0819270506371379,-1.82235487838552,-4.43992848969714,-0.587623021791245,"GCOM1///POLR2M","GRINL1A complex locus 1///RNA polymerase II subunit M",TRUE
+"212244_at",0.620912785033482,0.0904776434280745,-1.77006349244591,-4.51901051171392,-0.508633267307305,"GCOM1///POLR2M","GRINL1A complex locus 1///RNA polymerase II subunit M",TRUE
+"239099_at",0.944505992058939,0.750785092288497,-0.32157983342035,-5.88943967392951,-0.289137499733565,"GCOM1///POLR2M","GRINL1A complex locus 1///RNA polymerase II subunit M",TRUE
+"235310_at",0.852409445602775,0.458310404856574,0.754811956437903,-5.66592945815511,0.57536115164103,"GCSAM","germinal center associated signaling and motility",TRUE
+"1552908_at",0.712948021516228,0.187052212482526,-1.36146478083372,-5.07507311044249,-1.15771272302803,"GCSAML","germinal center associated signaling and motility like",TRUE
+"232452_at",0.658590024406624,0.12678913462397,1.58652844442164,-4.78286369401994,1.31040052383999,"GCSAML-AS1","GCSAML antisense RNA 1",TRUE
+"224209_s_at",0.171054203824867,0.00147039310273854,3.62922585039092,-0.996395871178466,4.23686257504966,"GDA","guanine deaminase",TRUE
+"1569555_at",0.615821255316333,0.0867391726901359,1.79237740503309,-4.48546906789745,0.688752666908625,"GDA","guanine deaminase",TRUE
+"221279_at",0.969642324744141,0.854980423062459,0.18491171436399,-5.92304336049472,0.163832666859049,"GDAP1","ganglioside induced differentiation associated protein 1",TRUE
+"226271_at",0.979976490833035,0.90441217812635,0.121471933363864,-5.93249920902284,0.110629132400211,"GDAP1","ganglioside induced differentiation associated protein 1",TRUE
+"226269_at",0.991059530537351,0.958155953606749,-0.0530646315182819,-5.93831207460318,-0.038893475515966,"GDAP1","ganglioside induced differentiation associated protein 1",TRUE
+"219668_at",0.716472449896956,0.192258570563735,1.34491560177161,-5.0951100834711,0.754558183575217,"GDAP1L1","ganglioside induced differentiation associated protein 1 like 1",TRUE
+"1554154_at",0.678455276397227,0.145978013196835,-1.50683812610182,-4.89043455914892,-0.607069316107703,"GDAP2","ganglioside induced differentiation associated protein 2",TRUE
+"219473_at",0.998347572104896,0.992729154287017,-0.00921615701026098,-5.93964211088476,-0.00369734683476963,"GDAP2","ganglioside induced differentiation associated protein 2",TRUE
+"202593_s_at",0.931560290412494,0.697451375135337,0.393857089122483,-5.86440972647692,0.136004330154634,"GDE1","glycerophosphodiester phosphodiesterase 1",TRUE
+"226214_at",0.988098729256575,0.943193011750992,-0.0720697526248837,-5.93715396748422,-0.0258643481985796,"GDE1","glycerophosphodiester phosphodiesterase 1",TRUE
+"206159_at",0.897710071620737,0.585338162840042,-0.553686667714526,-5.79145813587458,-0.443992148277065,"GDF10","growth differentiation factor 10",TRUE
+"217498_at",0.478691006415319,0.0267716138801177,-2.37237906867375,-3.51701240987723,-1.87275154770637,"GDF11","growth differentiation factor 11",TRUE
+"226232_at",0.774230543658252,0.286431372760412,-1.0923115161451,-5.37467781699827,-0.531270763353262,"GDF11","growth differentiation factor 11",TRUE
+"216860_s_at",0.783644735214763,0.306234173069934,1.04733994591252,-5.4190858808181,0.832509479660329,"GDF11","growth differentiation factor 11",TRUE
+"226234_at",0.930409774479405,0.692267546608566,0.400991008846492,-5.86166876984576,0.3376312855947,"GDF11","growth differentiation factor 11",TRUE
+"216854_at",0.932780653113734,0.7030848637491,0.386127857133958,-5.86732469598399,0.170594226767605,"GDF11","growth differentiation factor 11",TRUE
+"221576_at",0.73223722457785,0.216307718328628,1.27272948848936,-5.180088662348,0.434137756818079,"GDF15","growth differentiation factor 15",TRUE
+"229868_s_at",0.799008022536007,0.333632706448018,0.988391067399851,-5.47474550265108,0.74055420565144,"GDF15","growth differentiation factor 15",TRUE
+"221577_x_at",0.812302873476553,0.360355535055326,-0.934032263777968,-5.52346681847675,-1.15312814000774,"GDF15","growth differentiation factor 15",TRUE
+"221136_at",0.977858230085336,0.89263656632024,-0.136528342977701,-5.93060870569319,-0.0867659721642884,"GDF2","growth differentiation factor 2",TRUE
+"220053_at",0.874305976196739,0.520265180499957,0.653331879584007,-5.73389562385545,0.363522563452285,"GDF3","growth differentiation factor 3",TRUE
+"206614_at",0.980264692225439,0.907725585312972,-0.11724071249614,-5.93299082746941,-0.0876219187423395,"GDF5","growth differentiation factor 5",TRUE
+"214238_at",0.959357995170594,0.816265537699213,-0.235132355626479,-5.91279093149965,-0.120573804911115,"GDF7","growth differentiation factor 7",TRUE
+"221314_at",0.683019114815084,0.152139406297283,1.48307795416115,-4.92165150849435,0.531793019348015,"GDF9","growth differentiation factor 9",TRUE
+"201864_at",0.715352956634026,0.191084421634085,-1.3486167172831,-5.09064674432205,-0.488003224840387,"GDI1","GDP dissociation inhibitor 1",TRUE
+"200008_s_at",0.725181883744124,0.203830843759531,1.30935364116914,-5.13746968400791,0.4835293405319,"GDI2","GDP dissociation inhibitor 2",TRUE
+"200009_at",0.731054546207485,0.214159405077943,1.27891712799835,-5.17296044421546,0.352378120475358,"GDI2","GDP dissociation inhibitor 2",TRUE
+"221359_at",0.545172890661853,0.0469441969681939,2.10404563248479,-3.98670277492426,1.33564245074221,"GDNF","glial cell derived neurotrophic factor",TRUE
+"230090_at",0.872668627020452,0.516616944188016,-0.659110629166247,-5.73027680811766,-0.298363667873783,"GDNF","glial cell derived neurotrophic factor",TRUE
+"1555606_a_at",0.721317419960934,0.19761557851104,-1.3282510929023,-5.11507897614225,-0.571469924676238,"GDPD1","glycerophosphodiester phosphodiesterase domain containing 1",TRUE
+"238681_at",0.796378050779806,0.328807511379345,-0.998521200654398,-5.4653884402337,-0.702203204311336,"GDPD1","glycerophosphodiester phosphodiesterase domain containing 1",TRUE
+"1560227_at",0.857287594027564,0.472238254081568,-0.73133608132667,-5.68248111740392,-0.762333826300215,"GDPD1","glycerophosphodiester phosphodiesterase domain containing 1",TRUE
+"220291_at",0.751464513744428,0.244532500596199,1.19549507714355,-5.26655736104187,0.483723350000952,"GDPD2","glycerophosphodiester phosphodiesterase domain containing 2",TRUE
+"219722_s_at",0.913572663544659,0.637492025781791,-0.47777230278349,-5.82911077516976,-0.307993095246424,"GDPD3","glycerophosphodiester phosphodiesterase domain containing 3",TRUE
+"32502_at",0.718812966125406,0.194833971205563,-1.33685925927993,-5.10479001643415,-0.81795241275474,"GDPD5","glycerophosphodiester phosphodiesterase domain containing 5",TRUE
+"213343_s_at",0.725168361556674,0.203590934611704,-1.31007469256454,-5.13662031737719,-1.47343540474081,"GDPD5","glycerophosphodiester phosphodiesterase domain containing 5",TRUE
+"1565150_at",0.800179799309599,0.33580515671154,-0.983863165428675,-5.47889979999115,-0.649467461949169,"GDPGP1","GDP-D-glucose phosphorylase 1",TRUE
+"204472_at",0.940668681806864,0.734596255935874,-0.343316966994873,-5.882437526914,-0.387429431347434,"GEM","GTP binding protein overexpressed in skeletal muscle",TRUE
+"205063_at",0.54295328972902,0.045982372298497,-2.11418608488026,-3.96958568355682,-0.877748861839896,"GEMIN2","gem nuclear organelle associated protein 2",TRUE
+"211114_x_at",0.643215798394085,0.113725964756756,-1.64672579859887,-4.6987440344735,-0.55168152987415,"GEMIN2","gem nuclear organelle associated protein 2",TRUE
+"210779_x_at",0.692289844352812,0.161764365988074,-1.44748113965163,-4.96766909229976,-0.587404311050546,"GEMIN2","gem nuclear organelle associated protein 2",TRUE
+"211115_x_at",0.738061563377262,0.224761852157705,-1.24882850998124,-5.20734488395802,-0.402620749508136,"GEMIN2","gem nuclear organelle associated protein 2",TRUE
+"217099_s_at",0.809658961073821,0.352947630146016,0.948819094339502,-5.51046323106365,0.350194719798781,"GEMIN4","gem nuclear organelle associated protein 4",TRUE
+"205527_s_at",0.957571530817866,0.809246732212754,0.244299785440241,-5.91065612677534,0.128585641876867,"GEMIN4","gem nuclear organelle associated protein 4",TRUE
+"225712_at",0.978072252406502,0.89387304128648,0.134945916428148,-5.9308177565428,0.0540104159612529,"GEMIN5","gem nuclear organelle associated protein 5",TRUE
+"230118_at",0.62932992642067,0.100232373100525,1.71536163701459,-4.59992352414537,0.469851633062538,"GEMIN6","gem nuclear organelle associated protein 6",TRUE
+"219539_at",0.887865061216281,0.553228361520747,0.602086949257886,-5.7646446902178,0.23910549722401,"GEMIN6","gem nuclear organelle associated protein 6",TRUE
+"1555751_a_at",0.80281660809421,0.340538139459002,-0.97406778081526,-5.4878274917743,-0.320479285599314,"GEMIN7","gem nuclear organelle associated protein 7",TRUE
+"219085_s_at",0.870460291516522,0.509221260615564,0.670895166072093,-5.7228023557908,0.478915806493474,"GEMIN7","gem nuclear organelle associated protein 7",TRUE
+"222821_s_at",0.879665002659836,0.534234593750706,-0.631407486496875,-5.7473468720263,-0.188344809569507,"GEMIN7","gem nuclear organelle associated protein 7",TRUE
+"222854_s_at",0.153726668922469,0.00115415559227085,-3.72913491289018,-0.78298585359734,-1.50834623439432,"GEMIN8","gem nuclear organelle associated protein 8",TRUE
+"219252_s_at",0.44839970337033,0.0213174967063571,-2.47774504646738,-3.32381219524441,-0.902031120211182,"GEMIN8","gem nuclear organelle associated protein 8",TRUE
+"230758_at",0.453601396285638,0.021909392386374,-2.46517031301299,-3.34710745534054,-0.91270830416322,"GEMIN8","gem nuclear organelle associated protein 8",TRUE
+"1557267_s_at",0.820293495506061,0.379312199062217,0.897096019644277,-5.55512659838151,0.420722506979105,"GEN1","GEN1, Holliday junction 5' flap endonuclease",TRUE
+"228286_at",0.985498770484702,0.929777327053079,-0.0891325792386424,-5.93581469156612,-0.0364020572357795,"GEN1","GEN1, Holliday junction 5' flap endonuclease",TRUE
+"227588_s_at",0.526253358601247,0.0396220971701701,2.18650497871334,-3.84601170533869,1.34306411351922,"GET4","golgi to ER traffic protein 4",TRUE
+"224816_at",0.850984014275628,0.454059164386269,0.762062242076092,-5.66071759238084,0.542457021077356,"GET4","golgi to ER traffic protein 4",TRUE
+"224808_s_at",0.937113154905832,0.720649662159664,0.362179186293119,-5.87599475077883,0.122709761424526,"GET4","golgi to ER traffic protein 4",TRUE
+"223811_s_at",0.889294016704883,0.556835494501905,-0.596579038491263,-5.76780556948796,-0.213577644230259,"GET4///SUN1","golgi to ER traffic protein 4///Sad1 and UNC84 domain containing 1",TRUE
+"203540_at",0.769258076576208,0.276441035687774,1.11585345938384,-5.35076796774259,0.52387597485918,"GFAP","glial fibrillary acidic protein",TRUE
+"229259_at",0.919354071504066,0.656694524026319,0.450546226255858,-5.84129433587988,0.163889051606864,"GFAP","glial fibrillary acidic protein",TRUE
+"203539_s_at",0.941833562132083,0.738995912122243,0.337393181594375,-5.88439064135875,0.112707641171526,"GFAP","glial fibrillary acidic protein",TRUE
+"204659_s_at",0.692289844352812,0.161818991528884,-1.44728406175592,-4.96792133596693,-0.64037628488411,"GFER","growth factor, augmenter of liver regeneration",TRUE
+"204660_at",0.871451481476429,0.512446074488022,-0.665744993096611,-5.7260845126706,-0.300303428660061,"GFER","growth factor, augmenter of liver regeneration",TRUE
+"206589_at",0.418769817352331,0.0171643925137005,2.57641796655632,-3.13888931703652,1.91515823573478,"GFI1","growth factor independent 1 transcriptional repressor",TRUE
+"208501_at",0.67571432533675,0.142324666858517,-1.52131635378834,-4.87121791275747,-1.2381243704465,"GFI1B","growth factor independent 1B transcriptional repressor",TRUE
+"237403_at",0.94333312187812,0.74578064168595,0.328282072572655,-5.88732900122797,0.135666316887962,"GFI1B","growth factor independent 1B transcriptional repressor",TRUE
+"232295_at",0.54295328972902,0.046156249047579,2.11233887591809,-3.97270768642908,1.83874935337395,"GFM1","G elongation factor mitochondrial 1",TRUE
+"220903_at",0.747587302711183,0.239459215157436,1.20886055752378,-5.25192868342429,0.781096121655837,"GFM1","G elongation factor mitochondrial 1",TRUE
+"225161_at",0.914588178928864,0.640184010669921,0.473933819271273,-5.83087084724534,0.147987015617849,"GFM1","G elongation factor mitochondrial 1",TRUE
+"225153_at",0.914873260596855,0.641340659407656,-0.472286781232863,-5.83162180925558,-0.159478407922656,"GFM1","G elongation factor mitochondrial 1",TRUE
+"232296_s_at",0.928819762424586,0.68667678336832,0.408708766241491,-5.85864894995065,0.123092714504091,"GFM1","G elongation factor mitochondrial 1",TRUE
+"225158_at",0.944785393058556,0.751531069549806,0.32058207231871,-5.88975020357006,0.107324955527524,"GFM1","G elongation factor mitochondrial 1",TRUE
+"231917_at",0.913300726876965,0.636519593521718,0.479160676878743,-5.82847073933165,0.127671019933665,"GFM2","G elongation factor mitochondrial 2",TRUE
+"231918_s_at",0.962555471240652,0.829622155041678,-0.217743001699464,-5.91661718451807,-0.0659782070767108,"GFM2","G elongation factor mitochondrial 2",TRUE
+"225392_at",0.974435013896831,0.874912234798029,0.15925309567862,-5.92733834975056,0.0493088832734312,"GFM2","G elongation factor mitochondrial 2",TRUE
+"1554486_a_at",0.152865811663982,0.00111590954392287,3.74301023935864,-0.753276622573026,1.66386499150263,"GFOD1","glucose-fructose oxidoreductase domain containing 1",TRUE
+"219821_s_at",0.565956563686213,0.0568210851589538,2.00947352102665,-4.14375700455634,1.03703430338537,"GFOD1","glucose-fructose oxidoreductase domain containing 1",TRUE
+"221028_s_at",0.516444287133032,0.0363386461185789,-2.22806330487686,-3.77384042009411,-0.800578459137787,"GFOD2","glucose-fructose oxidoreductase domain containing 2",TRUE
+"214076_at",0.92051722798026,0.66171812958774,-0.443481091251873,-5.84434146677386,-0.302677559314994,"GFOD2","glucose-fructose oxidoreductase domain containing 2",TRUE
+"202722_s_at",0.769774279128662,0.277242622260208,1.11394195424403,-5.35272621970947,0.338303035038305,"GFPT1","glutamine--fructose-6-phosphate transaminase 1",TRUE
+"202721_s_at",0.769847953580141,0.278207494978651,1.11164639786109,-5.35507398175043,0.326234691975417,"GFPT1","glutamine--fructose-6-phosphate transaminase 1",TRUE
+"227027_at",0.928295253101366,0.684982297112242,0.41105289010428,-5.85772052001342,0.151943634572005,"GFPT1","glutamine--fructose-6-phosphate transaminase 1",TRUE
+"226886_at",0.959451355429682,0.816599215958297,0.234697049334613,-5.91289028120418,0.0962839663748785,"GFPT1","glutamine--fructose-6-phosphate transaminase 1",TRUE
+"205100_at",0.519956259865057,0.0376154138502199,2.21151297148039,-3.80268140244433,1.13696307204598,"GFPT2","glutamine-fructose-6-phosphate transaminase 2",TRUE
+"227550_at",0.632949074657601,0.103782258979384,-1.69657984611702,-4.62726779590197,-2.90788150576423,"GFRA1","GDNF family receptor alpha 1",TRUE
+"205696_s_at",0.724623760403195,0.202046442201129,-1.3147325922437,-5.13112399378628,-2.02333316472941,"GFRA1","GDNF family receptor alpha 1",TRUE
+"230163_at",0.896118635245982,0.57807450600182,-0.564515008241422,-5.78564826716188,-0.751158572219317,"GFRA1","GDNF family receptor alpha 1",TRUE
+"205721_at",0.723649742218726,0.20030705700988,1.32001158010592,-5.12487487247771,0.544021221892157,"GFRA2","GDNF family receptor alpha 2",TRUE
+"205722_s_at",0.989586772349659,0.949458464616306,-0.0641088149596289,-5.93768187867964,-0.0276030218713128,"GFRA2","GDNF family receptor alpha 2",TRUE
+"214479_at",0.849935057946582,0.452175257653742,0.765288223949499,-5.65838345465558,0.392301105795487,"GFRA3","GDNF family receptor alpha 3",TRUE
+"229936_at",0.945820394457833,0.755369587577073,0.315453190242381,-5.89133136617383,0.246969241594307,"GFRA3","GDNF family receptor alpha 3",TRUE
+"234868_s_at",0.908709061737317,0.620469641955173,-0.502216900114537,-5.81757661426953,-0.371778543833203,"GFRA4","GDNF family receptor alpha 4",TRUE
+"221199_at",0.979588787486838,0.901873664942219,-0.124715147841586,-5.93211060341734,-0.0366338726075508,"GFRA4","GDNF family receptor alpha 4",TRUE
+"217560_at",0.708702460344186,0.180717268429449,1.38209914924176,-5.04980404994298,0.795769377254527,"GGA1","golgi associated, gamma adaptin ear containing, ARF binding protein 1",TRUE
+"1554670_at",0.942130645985517,0.739574711032435,0.336614795219129,-5.88464478185532,0.207209583694912,"GGA1","golgi associated, gamma adaptin ear containing, ARF binding protein 1",TRUE
+"45572_s_at",0.942502815705589,0.741757640518632,0.333681027921135,-5.88559742827047,0.086794734773127,"GGA1","golgi associated, gamma adaptin ear containing, ARF binding protein 1",TRUE
+"218114_at",0.975242094553739,0.879892334722525,-0.152859851648613,-5.92830910240633,-0.0464019555474877,"GGA1","golgi associated, gamma adaptin ear containing, ARF binding protein 1",TRUE
+"50277_at",0.97928472590149,0.899331355802553,0.127964585776495,-5.93171099939691,0.0331882630565961,"GGA1","golgi associated, gamma adaptin ear containing, ARF binding protein 1",TRUE
+"213772_s_at",0.166359483989286,0.00136008576759417,-3.66143983512313,-0.927689138808141,-1.5450317487366,"GGA2","golgi associated, gamma adaptin ear containing, ARF binding protein 2",TRUE
+"210658_s_at",0.47652109797903,0.0263905968848743,-2.37906194084576,-3.5048960847637,-0.8272699964064,"GGA2","golgi associated, gamma adaptin ear containing, ARF binding protein 2",TRUE
+"208913_at",0.494964585580862,0.0301007269694809,-2.31745088349855,-3.61586625882005,-0.660578130271556,"GGA2","golgi associated, gamma adaptin ear containing, ARF binding protein 2",TRUE
+"214190_x_at",0.499428826990278,0.0315351590744927,-2.29548842455919,-3.65501874999794,-0.847566924686621,"GGA2","golgi associated, gamma adaptin ear containing, ARF binding protein 2",TRUE
+"208915_s_at",0.548924465506383,0.0485418358651039,-2.08760725430088,-4.01433860249319,-0.628593325771167,"GGA2","golgi associated, gamma adaptin ear containing, ARF binding protein 2",TRUE
+"208914_at",0.767945391174396,0.27043177958638,-1.13031384008367,-5.33585772275076,-0.352623951992292,"GGA2","golgi associated, gamma adaptin ear containing, ARF binding protein 2",TRUE
+"214189_s_at",0.790240875783718,0.319449973574125,-1.01846451917536,-5.44671432406225,-0.643645077139868,"GGA2","golgi associated, gamma adaptin ear containing, ARF binding protein 2",TRUE
+"214233_at",0.819018525257656,0.374935090561277,0.90551399828326,-5.54801485326806,0.497496223137243,"GGA2","golgi associated, gamma adaptin ear containing, ARF binding protein 2",TRUE
+"209411_s_at",0.90227173306771,0.601129563322228,-0.530372275918074,-5.80359614853595,-0.218146565837896,"GGA3","golgi associated, gamma adaptin ear containing, ARF binding protein 3",TRUE
+"211815_s_at",0.973567634886313,0.872853427991746,0.16189807675511,-5.92692513305713,0.0524173637250502,"GGA3","golgi associated, gamma adaptin ear containing, ARF binding protein 3",TRUE
+"237869_at",0.784918343662568,0.309570536539204,-1.03996867308621,-5.42620497341116,-0.842834497422553,"GGACT","gamma-glutamylamine cyclotransferase",TRUE
+"232422_at",0.997890350692744,0.990099989277791,0.0125489124161761,-5.93960678067491,0.00545777643669609,"GGACT","gamma-glutamylamine cyclotransferase",TRUE
+"215380_s_at",0.7768734672127,0.294806889648481,-1.07302772422321,-5.39392446824949,-0.441645009622931,"GGCT","gamma-glutamylcyclotransferase",TRUE
+"205351_at",0.799043197262752,0.333720190388568,0.988208338166404,-5.47491349063635,0.342345911230343,"GGCX","gamma-glutamyl carboxylase",TRUE
+"235413_at",0.887083096014278,0.551483253807528,0.604758387388666,-5.76310150421585,0.221146005088489,"GGCX","gamma-glutamyl carboxylase",TRUE
+"213705_at",0.889452275006221,0.557524692707452,0.595528787531314,-5.7684051015731,0.178977094379672,"GGCX","gamma-glutamyl carboxylase",TRUE
+"214005_at",0.93565329131222,0.713548712270295,-0.371834188512012,-5.87256525984137,-0.206845619663348,"GGCX","gamma-glutamyl carboxylase",TRUE
+"214006_s_at",0.984161165881616,0.922771498203022,-0.0980534472446862,-5.93500170746915,-0.0381743062013431,"GGCX","gamma-glutamyl carboxylase",TRUE
+"203560_at",0.948429371744093,0.765341847451043,-0.302168504257936,-5.89530937722961,-0.131958167733647,"GGH","gamma-glutamyl hydrolase",TRUE
+"244305_at",0.619091824173668,0.0894073899163289,1.77636919703217,-4.50956313888414,0.729565246022423,"GGN","gametogenetin",TRUE
+"231420_at",0.98661350081953,0.937684091964387,-0.0790733605537079,-5.93663853040725,-0.0499020443519962,"GGN","gametogenetin",TRUE
+"233937_at",0.723973974120865,0.200898852712365,1.31821149865036,-5.12700813445466,0.608554282015535,"GGNBP2","gametogenetin binding protein 2",TRUE
+"218079_s_at",0.809930331505913,0.353590557528629,-0.947527509083303,-5.51160652187206,-0.362269456776771,"GGNBP2","gametogenetin binding protein 2",TRUE
+"1554419_x_at",0.893175412268596,0.567697251078964,-0.580104569747124,-5.77709228112638,-0.38470191655135,"GGNBP2","gametogenetin binding protein 2",TRUE
+"233936_s_at",0.959203345279235,0.815329453404314,-0.236353790391689,-5.91251118638856,-0.0738369754595123,"GGNBP2","gametogenetin binding protein 2",TRUE
+"202322_s_at",0.76029267756668,0.258762704390185,-1.15908151057077,-5.30569208340194,-0.510192750546455,"GGPS1","geranylgeranyl diphosphate synthase 1",TRUE
+"202321_at",0.769687659596967,0.27713616552128,-1.11419558455258,-5.35246655795304,-0.606134513024978,"GGPS1","geranylgeranyl diphosphate synthase 1",TRUE
+"233837_at",0.99783553534859,0.989932043528778,0.0127618066379886,-5.93960415615265,0.0093320491133646,"GGT1","gamma-glutamyltransferase 1",TRUE
+"208284_x_at",0.629618998226163,0.100570665936421,-1.71354760756543,-4.60257439593964,-1.19620904044286,"GGT2///GGTLC1///GGTLC2///GGT1","gamma-glutamyltransferase 2///gamma-glutamyltransferase light chain 1///gamma-glutamyltransferase light chain 2///gamma-glutamyltransferase 1",TRUE
+"207131_x_at",0.712391714067656,0.186412442784618,-1.3635233433555,-5.07256638934482,-1.05278615841713,"GGT2///GGTLC1///GGTLC2///GGT1","gamma-glutamyltransferase 2///gamma-glutamyltransferase light chain 1///gamma-glutamyltransferase light chain 2///gamma-glutamyltransferase 1",TRUE
+"209919_x_at",0.734585436592173,0.219159719098153,-1.26458767790385,-5.18942310178476,-0.917786907830182,"GGT2///GGTLC1///GGTLC2///GGT1","gamma-glutamyltransferase 2///gamma-glutamyltransferase light chain 1///gamma-glutamyltransferase light chain 2///gamma-glutamyltransferase 1",TRUE
+"211417_x_at",0.737135512363148,0.223203419927909,-1.25318202415781,-5.2024132104174,-0.85663667089017,"GGT2///GGTLC1///GGTLC2///GGT1","gamma-glutamyltransferase 2///gamma-glutamyltransferase light chain 1///gamma-glutamyltransferase light chain 2///gamma-glutamyltransferase 1",TRUE
+"205582_s_at",0.856063712917985,0.469416440571373,-0.736058833757367,-5.67919119401164,-0.712961015720621,"GGT5","gamma-glutamyltransferase 5",TRUE
+"236225_at",0.897011777275924,0.582429023493718,-0.558015382522405,-5.78914869411509,-0.564100848384726,"GGT6","gamma-glutamyltransferase 6",TRUE
+"226469_s_at",0.888333011828712,0.554374591657395,-0.600334684579591,-5.76565332275918,-0.385086470102951,"GGT7","gamma-glutamyltransferase 7",TRUE
+"226471_at",0.891249845423426,0.5604987006978,-0.591004493780883,-5.7709761057995,-0.571877879465612,"GGT7","gamma-glutamyltransferase 7",TRUE
+"226470_at",0.986342822130003,0.933716519077958,-0.0841199118894157,-5.93623753193369,-0.0737825869599078,"GGT7","gamma-glutamyltransferase 7",TRUE
+"228376_at",0.873540013139054,0.51888202529788,-0.655520133485983,-5.73252887386615,-0.309373733629514,"GGTA1P","glycoprotein, alpha-galactosyltransferase 1 pseudogene",TRUE
+"211416_x_at",0.900692252557887,0.595776817645362,-0.538241137745393,-5.79955618475999,-0.242544500466476,"GGTLC1","gamma-glutamyltransferase light chain 1",TRUE
+"209918_at",0.97689149311934,0.889461041706193,-0.140593989585128,-5.93006044817476,-0.0597376051629448,"GGTLC2","gamma-glutamyltransferase light chain 2",TRUE
+"205840_x_at",0.593339168375633,0.0703646131502657,-1.90117175345289,-4.31762974640344,-0.946849428898317,"GH1","growth hormone 1",TRUE
+"211151_x_at",0.803111243433434,0.340858934675293,-0.973407249720183,-5.48842658077192,-0.642237935780008,"GH1","growth hormone 1",TRUE
+"206885_x_at",0.831487912516861,0.406137501479239,-0.846841948133975,-5.5962994355877,-0.520608058743357,"GH1","growth hormone 1",TRUE
+"206886_x_at",0.904885221062616,0.610377325257177,-0.516856580180362,-5.8104000548588,-0.325445654981062,"GH1","growth hormone 1",TRUE
+"208356_x_at",0.740270784944871,0.228687994017236,1.23796196477483,-5.21959015182172,0.37077552129685,"GH1///CSHL1///CSH1","growth hormone 1///chorionic somatomammotropin hormone like 1///chorionic somatomammotropin hormone 1",TRUE
+"202493_x_at",0.91671872326659,0.647824057463704,0.463078922949528,-5.83577295018444,0.160758335125148,"GH1///CSHL1///CSH1","growth hormone 1///chorionic somatomammotropin hormone like 1///chorionic somatomammotropin hormone 1",TRUE
+"206475_x_at",0.943631120237335,0.747766827432855,0.325620243301427,-5.88817242476694,0.137467513189487,"GH1///CSHL1///CSH1","growth hormone 1///chorionic somatomammotropin hormone like 1///chorionic somatomammotropin hormone 1",TRUE
+"211739_x_at",0.981057862678091,0.910719557754485,0.113419296573614,-5.93341987306375,0.0527991615461434,"GH1///CSHL1///CSH2///CSH1","growth hormone 1///chorionic somatomammotropin hormone like 1///chorionic somatomammotropin hormone 2///chorionic somatomammotropin hormone 1",TRUE
+"203807_x_at",0.985736911886368,0.931205899411677,-0.0873144408908244,-5.93597088529535,-0.0378466147162886,"GH1///CSHL1///CSH2///CSH1","growth hormone 1///chorionic somatomammotropin hormone like 1///chorionic somatomammotropin hormone 2///chorionic somatomammotropin hormone 1",TRUE
+"206195_x_at",0.820536502908875,0.380401267351305,0.895011486533246,-5.55687818167229,0.318782597537971,"GH2","growth hormone 2",TRUE
+"211508_s_at",0.841967750949524,0.434699834456672,0.795610367815798,-5.63598968745102,0.608650820174842,"GH2","growth hormone 2",TRUE
+"208068_x_at",0.837067957688307,0.419298537809712,0.82296327107645,-5.61508735643339,0.510542142438514,"GH2///GH1///CSHL1///CSH1","growth hormone 2///growth hormone 1///chorionic somatomammotropin hormone like 1///chorionic somatomammotropin hormone 1",TRUE
+"208069_x_at",0.896698944714083,0.581693976609403,0.559110815266202,-5.7885614952138,0.27648106646405,"GH2///GH1///CSHL1///CSH1","growth hormone 2///growth hormone 1///chorionic somatomammotropin hormone like 1///chorionic somatomammotropin hormone 1",TRUE
+"227159_at",0.884729701742031,0.544047328217881,-0.616191654366405,-5.75642248472388,-0.217935758797086,"GHDC","GH3 domain containing",TRUE
+"1570125_at",0.669423128374382,0.135485758468262,1.54925995157651,-4.83371620006456,1.28814713534896,"GHET1","gastric carcinoma proliferation enhancing transcript 1",TRUE
+"209248_at",0.643082025527735,0.113364611231722,-1.64847179736818,-4.6962682216139,-0.528905136727309,"GHITM","growth hormone inducible transmembrane protein",TRUE
+"1554510_s_at",0.877223961993707,0.526471188040118,-0.643552665461337,-5.73994995181647,-0.232205997906053,"GHITM","growth hormone inducible transmembrane protein",TRUE
+"209249_s_at",0.899808883319249,0.592161308851105,-0.54357564717175,-5.79678448286845,-0.177573545643108,"GHITM","growth hormone inducible transmembrane protein",TRUE
+"205498_at",0.547792693371613,0.0481716921761448,-2.09137201852202,-4.0080216736861,-3.12894149238739,"GHR","growth hormone receptor",TRUE
+"214524_at",0.889452275006221,0.55744758727427,0.595646252881017,-5.76833809758832,0.364438470165709,"GHRH","growth hormone releasing hormone",TRUE
+"211545_at",0.605913415325856,0.0793471650413366,1.83905997395626,-4.41431507268401,1.21515896021797,"GHRHR","growth hormone releasing hormone receptor",TRUE
+"211544_s_at",0.878278790222455,0.530849014750911,0.636692075635694,-5.74414498983963,0.563265326992762,"GHRHR","growth hormone releasing hormone receptor",TRUE
+"207825_s_at",0.997608949249317,0.987969497656749,0.0152496495933509,-5.93957021396997,0.010160807074084,"GHRHR","growth hormone releasing hormone receptor",TRUE
+"237647_at",0.694819513561858,0.16429343062023,-1.43841251507506,-4.97924718511538,-0.764632558610234,"GHRL","ghrelin/obestatin prepropeptide",TRUE
+"223862_at",0.886940322815928,0.550614855253412,0.606089399585691,-5.76233016877627,0.265661623457367,"GHRL","ghrelin/obestatin prepropeptide",TRUE
+"244695_at",0.849646596450765,0.45088683305159,0.767499185452698,-5.65677834751888,0.534215478225906,"GHRLOS","ghrelin opposite strand/antisense RNA",TRUE
+"239617_at",0.95560177469038,0.796546972465584,0.260942388659845,-5.90657320921385,0.109459940114327,"GHRLOS","ghrelin opposite strand/antisense RNA",TRUE
+"221360_s_at",0.756313947022433,0.251506127947015,1.17745841767012,-5.28607408131862,0.448897401494596,"GHSR","growth hormone secretagogue receptor",TRUE
+"224554_at",0.833947935066508,0.411749876673441,-0.836600071473892,-5.60441932737379,-0.459172713991358,"GHSR","growth hormone secretagogue receptor",TRUE
+"237101_at",0.941947927515757,0.739168726699042,0.33716075306,-5.88446658928224,0.287635950893176,"GHSR","growth hormone secretagogue receptor",TRUE
+"220058_at",0.656983045601852,0.124992000738006,1.59449328227578,-4.77187313182572,1.01791961224177,"GID4","GID complex subunit 4 homolog",TRUE
+"228452_at",0.743553048228796,0.234020884104004,1.22342691377231,-5.23582513165698,0.403537848372412,"GID4","GID complex subunit 4 homolog",TRUE
+"225376_at",0.780785046445981,0.302531892253463,-1.05558657030868,-5.41106783612905,-0.434248258520276,"GID8","GID complex subunit 8 homolog",TRUE
+"218448_at",0.862800800218883,0.486643182833708,-0.707481061268867,-5.69879102061688,-0.29318843711058,"GID8","GID complex subunit 8 homolog",TRUE
+"207033_at",0.715973143624306,0.19165949574916,1.34680175974269,-5.09283676578838,0.888882658145857,"GIF","gastric intrinsic factor",TRUE
+"226768_at",0.839466826665106,0.425513518161584,-0.811851235396679,-5.62365882094811,-0.248677713334484,"GIGYF1","GRB10 interacting GYF protein 1",TRUE
+"236447_at",0.923376218980614,0.671054776879459,0.43041048933763,-5.84985407512033,0.29989375778877,"GIGYF1","GRB10 interacting GYF protein 1",TRUE
+"228755_at",0.993396893810682,0.968886744569702,0.0394476983946374,-5.93892558005016,0.0321753259601012,"GIGYF1","GRB10 interacting GYF protein 1",TRUE
+"212260_at",0.776927206114497,0.295139973863705,-1.0722690087726,-5.3946754610193,-0.269596575600101,"GIGYF2","GRB10 interacting GYF protein 2",TRUE
+"237052_x_at",0.779847351572723,0.30107028618193,-1.05886195773679,-5.40786757539857,-0.397178771493053,"GIGYF2","GRB10 interacting GYF protein 2",TRUE
+"212261_at",0.819479221404744,0.376641882704059,-0.902223859964094,-5.55080176255014,-0.214999255671479,"GIGYF2","GRB10 interacting GYF protein 2",TRUE
+"1558305_at",0.925679011537716,0.678628108266415,0.419864200493925,-5.85418394293243,0.288520665768983,"GIGYF2","GRB10 interacting GYF protein 2",TRUE
+"1552315_at",0.496742810480539,0.0303439275237191,-2.31366058950064,-3.62263864953598,-1.36408821041814,"GIMAP1","GTPase, IMAP family member 1",TRUE
+"236401_at",0.706668000657573,0.178529220675813,1.38935937511248,-5.04083806994554,0.709740240815059,"GIMAP1","GTPase, IMAP family member 1",TRUE
+"1552318_at",0.708894565317004,0.181101806139089,1.38083042269435,-5.05136685872884,0.93757878213245,"GIMAP1","GTPase, IMAP family member 1",TRUE
+"236583_at",0.937232018318296,0.721535804573456,-0.360976795346803,-5.8764156070398,-0.18140747739904,"GIMAP1","GTPase, IMAP family member 1",TRUE
+"1552316_a_at",0.961551569993665,0.825774698093924,-0.222744836364083,-5.91554656775957,-0.196643611441572,"GIMAP1","GTPase, IMAP family member 1",TRUE
+"64064_at",0.8289434059415,0.399924447406033,0.858285912139693,-5.58711753380387,0.301407460160751,"GIMAP1-GIMAP5///GIMAP5","GIMAP1-GIMAP5 readthrough///GTPase, IMAP family member 5",TRUE
+"218805_at",0.913697616562839,0.638235975747494,0.47671078350635,-5.82959890647963,0.242371449312216,"GIMAP1-GIMAP5///GIMAP5","GIMAP1-GIMAP5 readthrough///GTPase, IMAP family member 5",TRUE
+"215352_at",0.957868442073393,0.810494593525866,0.242668381935,-5.91104196725174,0.146673679822507,"GIMAP1-GIMAP5///GIMAP5","GIMAP1-GIMAP5 readthrough///GTPase, IMAP family member 5",TRUE
+"232024_at",0.965466249068251,0.838715142789113,-0.205944083298881,-5.91904677703049,-0.347194854028012,"GIMAP2","GTPase, IMAP family member 2",TRUE
+"219243_at",0.821424121108148,0.382851415291903,0.890336054513152,-5.56079311865567,0.631434138350991,"GIMAP4","GTPase, IMAP family member 4",TRUE
+"215353_at",0.776576421726155,0.293969861919821,1.07493706078456,-5.39203246476696,0.46851507964547,"GIMAP5","GTPase, IMAP family member 5",TRUE
+"229367_s_at",0.567292616148537,0.0573073441620989,2.00520752770722,-4.15072901049851,1.52177611359952,"GIMAP6","GTPase, IMAP family member 6",TRUE
+"219777_at",0.755940660414394,0.250637492015773,1.17968452872596,-5.28367930359769,0.985767034695256,"GIMAP6","GTPase, IMAP family member 6",TRUE
+"228071_at",0.956084625435459,0.80146323460778,-0.254491120169278,-5.9081876215251,-0.243266135256675,"GIMAP7","GTPase, IMAP family member 7",TRUE
+"240646_at",0.90578639555441,0.612130930748238,-0.514304704676023,-5.81166548471586,-0.210849874371292,"GIMAP8","GTPase, IMAP family member 8",TRUE
+"235306_at",0.930550700810831,0.692747089418,0.400330184208047,-5.86192470457134,0.155117293502324,"GIMAP8","GTPase, IMAP family member 8",TRUE
+"1554345_a_at",0.781852661006184,0.30330871142824,-1.05385033407056,-5.4127606403885,-0.360997319816546,"GIN1","gypsy retrotransposon integrase 1",TRUE
+"219467_at",0.899808883319249,0.59202737020905,-0.54377357304403,-5.79668113344763,-0.168876857889883,"GIN1","gypsy retrotransposon integrase 1",TRUE
+"225576_at",0.884769004468037,0.544504403515225,0.615486491228526,-5.75683791336177,0.236197477972658,"GINM1","glycoprotein integral membrane 1",TRUE
+"206102_at",0.590227662188097,0.0681609046009262,-1.91746578308192,-4.291893677037,-0.970121365191609,"GINS1","GINS complex subunit 1",TRUE
+"221521_s_at",0.760439386481756,0.259266460074145,-1.15782004070336,-5.30702882504147,-0.559217817487458,"GINS2","GINS complex subunit 2",TRUE
+"243136_at",0.961212424803935,0.824294569055168,-0.224670599986754,-5.91512791619907,-0.112898217768423,"GINS2","GINS complex subunit 2",TRUE
+"1557595_at",0.968269082055813,0.850865083456452,-0.190224750968595,-5.92207423214046,-0.0867945167640567,"GINS2","GINS complex subunit 2",TRUE
+"45633_at",0.869060996512026,0.505618397573173,0.676670748052835,-5.71909283205792,0.202113536475927,"GINS3","GINS complex subunit 3",TRUE
+"218719_s_at",0.956398858120188,0.802429018665585,0.253225093814242,-5.9084997273604,0.0715780491465878,"GINS3","GINS complex subunit 3",TRUE
+"235029_at",0.8017109011727,0.339132740684209,-0.976966591631846,-5.48519394444853,-0.614715053637371,"GINS4","GINS complex subunit 4",TRUE
+"1554356_at",0.869082033398093,0.505762459593792,-0.6764393660388,-5.71924202848307,-0.458693851411939,"GINS4","GINS complex subunit 4",TRUE
+"211767_at",0.901926599164492,0.600228646313657,-0.531694295545864,-5.80292145428587,-0.366206430524738,"GINS4","GINS complex subunit 4",TRUE
+"240778_at",0.980176424909863,0.906925380151167,0.118262370685999,-5.93287371657059,0.0502903562251671,"GINS4","GINS complex subunit 4",TRUE
+"207899_at",0.945498722604777,0.753621343871316,0.317788048140076,-5.8906146934799,0.158856656631742,"GIP","gastric inhibitory polypeptide",TRUE
+"207525_s_at",0.770666015522698,0.279074832031713,1.10958782927699,-5.35717571339135,0.456166526563452,"GIPC1","GIPC PDZ domain containing family member 1",TRUE
+"219970_at",0.135265250185742,0.00086520090189291,3.84759229229535,-0.528878531121562,3.56638436888414,"GIPC2","GIPC PDZ domain containing family member 2",TRUE
+"236548_at",0.384586587899771,0.0125412304860344,2.71697624113551,-2.8693731763421,1.7380165545535,"GIPC2","GIPC PDZ domain containing family member 2",TRUE
+"1553058_at",0.697412165374288,0.167886453421051,1.42572004111626,-4.99535203111934,0.448487253026835,"GIPC3","GIPC PDZ domain containing family member 3",TRUE
+"236730_at",0.93919895813272,0.727837217672667,0.352442017473622,-5.87936318518043,0.192544517331539,"GIPC3","GIPC PDZ domain containing family member 3",TRUE
+"208105_at",0.685360765794715,0.153985011378625,1.47611342462914,-4.9307260294542,0.567428516258475,"GIPR","gastric inhibitory polypeptide receptor",TRUE
+"231291_at",0.985361089461736,0.92749255266378,0.0920410451119144,-5.93555814133287,0.0486802637702093,"GIPR","gastric inhibitory polypeptide receptor",TRUE
+"218030_at",0.743474458360704,0.233805793801308,1.22400826435517,-5.23517896848417,0.298954567762774,"GIT1","GIT ArfGAP 1",TRUE
+"1556913_a_at",0.837067957688307,0.419473305009696,-0.822649390995742,-5.61533097179337,-0.23001554750263,"GIT2","GIT ArfGAP 2",TRUE
+"1556912_at",0.935094665155941,0.711502382522302,0.374623191794678,-5.87155802222196,0.316992247756203,"GIT2","GIT ArfGAP 2",TRUE
+"209876_at",0.939976205834042,0.73031285697574,-0.349096277129824,-5.8804996604459,-0.261084378266938,"GIT2","GIT ArfGAP 2",TRUE
+"225558_at",0.961212424803935,0.824304142885027,-0.224658140901304,-5.91513063626978,-0.0789610399358533,"GIT2","GIT ArfGAP 2",TRUE
+"204982_at",0.97545133752419,0.882861128967633,0.149051756200696,-5.92886846837626,0.150251502315974,"GIT2","GIT ArfGAP 2",TRUE
+"201667_at",0.708894565317004,0.18148722539461,1.37956093028539,-5.05292941858922,2.43666571148724,"GJA1","gap junction protein alpha 1",TRUE
+"1553044_at",0.714795139167042,0.190494375359908,1.35048339812331,-5.08839173547761,0.521766696680163,"GJA10","gap junction protein alpha 10",TRUE
+"239572_at",0.774230543658252,0.289413944317257,1.08539850084908,-5.38161268296214,0.750475734282228,"GJA3","gap junction protein alpha 3",TRUE
+"208590_x_at",0.819018525257656,0.374119933654029,-0.907088845369548,-5.5466775643929,-0.405442387780642,"GJA3","gap junction protein alpha 3",TRUE
+"40687_at",0.542476690934517,0.0455908622742406,2.11836847492234,-3.96251052509378,1.44843032466029,"GJA4","gap junction protein alpha 4",TRUE
+"204904_at",0.931370027472813,0.695875629608984,0.396023393369688,-5.86358252404432,0.268954278682982,"GJA4","gap junction protein alpha 4",TRUE
+"214466_at",0.454579023204608,0.0220243224960038,2.46276530341931,-3.35155565804679,2.49756280608784,"GJA5","gap junction protein alpha 5",TRUE
+"226701_at",0.527546822913581,0.0401035193352971,2.1806765095885,-3.85606690793645,3.07077421157895,"GJA5","gap junction protein alpha 5",TRUE
+"208489_at",0.960614707352139,0.821065513284485,-0.228874881923647,-5.91420146502525,-0.143433865273813,"GJA8","gap junction protein alpha 8",TRUE
+"221415_s_at",0.615821255316333,0.086286549149912,1.79513496619484,-4.48130275392965,0.841291753581228,"GJA9-MYCBP///GJA9///MYCBP","GJA9-MYCBP readthrough///gap junction protein alpha 9///MYC binding protein",TRUE
+"203360_s_at",0.976422537443518,0.88781905950752,-0.142697178747068,-5.92977052909255,-0.0452624076345369,"GJA9-MYCBP///GJA9///MYCBP","GJA9-MYCBP readthrough///gap junction protein alpha 9///MYC binding protein",TRUE
+"203359_s_at",0.647518308302168,0.118659657516773,-1.62334162586295,-4.73170836458077,-0.435151150579454,"GJA9-MYCBP///MYCBP","GJA9-MYCBP readthrough///MYC binding protein",TRUE
+"203361_s_at",0.7083523771159,0.180297480956654,-1.38348662563602,-5.04809360291671,-0.40668227171551,"GJA9-MYCBP///MYCBP","GJA9-MYCBP readthrough///MYC binding protein",TRUE
+"204973_at",0.835358873171281,0.414585514833154,0.831459065966057,-5.60846037933451,0.615913158902523,"GJB1","gap junction protein beta 1",TRUE
+"223278_at",0.40129202983775,0.014361051299349,2.65660311748987,-2.98597201433713,4.23499628894451,"GJB2","gap junction protein beta 2",TRUE
+"215243_s_at",0.0595361125571683,0.000131692922562501,4.61653835372729,1.13014142403507,2.84180678645656,"GJB3","gap junction protein beta 3",TRUE
+"205490_x_at",0.139748326424544,0.000922709571820037,3.82117368373852,-0.585636816592325,4.4227564461731,"GJB3","gap junction protein beta 3",TRUE
+"205491_s_at",0.763995234099495,0.263968571008896,1.14613186851854,-5.31935359471774,0.696762356833933,"GJB3","gap junction protein beta 3",TRUE
+"216579_at",0.934784679606929,0.710487647841711,-0.376007325544335,-5.87105539072423,-0.139822595687742,"GJB4","gap junction protein beta 4",TRUE
+"206156_at",0.183534093706442,0.00176903968599379,3.55266966628527,-1.15923223854851,3.09528816299025,"GJB5","gap junction protein beta 5",TRUE
+"231771_at",4.80462843277496e-07,8.78761487475987e-12,12.9041354063306,14.0836643877244,7.87885197850351,"GJB6","gap junction protein beta 6",TRUE
+"228563_at",0.491058836532701,0.0293784016223463,2.32887647823783,-3.59541268075112,2.30035194109753,"GJC1","gap junction protein gamma 1",TRUE
+"243502_at",0.494269525805545,0.0300313372606497,2.31853748012079,-3.61392357768442,2.48064840406909,"GJC1","gap junction protein gamma 1",TRUE
+"228776_at",0.542397752248982,0.0455375881402355,2.11894008381135,-3.9615428693697,4.03377554204191,"GJC1","gap junction protein gamma 1",TRUE
+"208460_at",0.552420073963858,0.0499802193131135,2.07321756819807,-4.03841536241916,2.4257825246427,"GJC1","gap junction protein gamma 1",TRUE
+"214302_x_at",0.501012247664528,0.0320534695187948,2.28777734087397,-3.66871373408608,0.772754677600491,"GJC2","gap junction protein gamma 2",TRUE
+"207025_at",0.915353407558177,0.643057841142691,0.469843999685104,-5.83273087625625,0.271442477160571,"GJC2","gap junction protein gamma 2",TRUE
+"221407_at",0.714590421965913,0.189998954176919,1.35205423821184,-5.08649208937707,0.344664680881736,"GJD2","gap junction protein delta 2",TRUE
+"230025_at",0.789795896476304,0.318376145160724,1.02077906960957,-5.44452543038872,0.352070886983541,"GJD3","gap junction protein delta 3",TRUE
+"1553511_at",0.979588787486838,0.902305197663829,-0.12416372424632,-5.93217739697728,-0.0387833161279794,"GJD3","gap junction protein delta 3",TRUE
+"234116_at",0.772959490113364,0.283453823077695,1.09926492035364,-5.36766289594726,0.35180466268903,"GJD4","gap junction protein delta 4",TRUE
+"214681_at",0.605913415325856,0.0793386533563907,-1.83911586389449,-4.41422909753265,-1.19564770239768,"GK","glycerol kinase",TRUE
+"215975_x_at",0.76858139690485,0.271682347664562,-1.12728531827403,-5.33899451458205,-0.481492983286891,"GK","glycerol kinase",TRUE
+"207387_s_at",0.775351898377291,0.292273727736192,-1.07881808114374,-5.38817741299177,-0.829503063389386,"GK","glycerol kinase",TRUE
+"217167_x_at",0.936560002465203,0.716753181219049,-0.367472741322189,-5.87412548941721,-0.170427569045726,"GK","glycerol kinase",TRUE
+"215977_x_at",0.98453870130544,0.924637571297643,-0.0956765181470292,-5.93522589006127,-0.0620008985846248,"GK","glycerol kinase",TRUE
+"215430_at",0.393258278493143,0.0134379143163579,2.68626382082825,-2.92884052596959,0.941692875401863,"GK2","glycerol kinase 2",TRUE
+"215966_x_at",0.91202803207519,0.631241987252753,-0.486712471050506,-5.8249575857309,-0.273668852483227,"GK3P","glycerol kinase 3 pseudogene",TRUE
+"241384_x_at",0.759156678237018,0.25677337815523,-1.16408089607501,-5.3003818297121,-0.566194480289516,"GK5","glycerol kinase 5 (putative)",TRUE
+"1553772_at",0.875938621758472,0.524294576057475,-0.646975264140002,-5.73784098838412,-0.201895286883293,"GK5","glycerol kinase 5 (putative)",TRUE
+"238121_at",0.901910595357431,0.60012229891524,-0.531850414626912,-5.80284167082607,-0.252581124500912,"GK5","glycerol kinase 5 (putative)",TRUE
+"216316_x_at",0.70573152022539,0.177810023554908,-1.39176120614733,-5.03786337724361,-0.643837785229708,"GK6P","glycerol kinase 6 pseudogene",TRUE
+"234192_s_at",0.812302873476553,0.359164401103081,-0.936395982462976,-5.52140074794609,-0.619148505121387,"GKAP1","G kinase anchoring protein 1",TRUE
+"229312_s_at",0.869082033398093,0.505680245452456,-0.67657140791187,-5.71915689312021,-0.294205682663092,"GKAP1","G kinase anchoring protein 1",TRUE
+"229311_at",0.975475861996229,0.883141327508055,-0.148692460775096,-5.92892051787707,-0.0871923407719595,"GKAP1","G kinase anchoring protein 1",TRUE
+"220191_at",0.954723352940649,0.794116867642228,-0.264135412527307,-5.90575931058518,-0.20237952014982,"GKN1","gastrokine 1",TRUE
+"238222_at",0.69971536436669,0.171207903877414,1.41417936049784,-5.00989381928335,0.941248202407899,"GKN2","gastrokine 2",TRUE
+"214430_at",0.820536502908875,0.380643992411718,-0.894547432581645,-5.55726760201372,-0.453101110120015,"GLA","galactosidase alpha",TRUE
+"206540_at",0.951339758531576,0.777422342312189,0.286149076509661,-5.899880625208,0.108471674003928,"GLB1L","galactosidase beta 1 like",TRUE
+"213713_s_at",0.93474377881867,0.710186893534735,-0.376417708625306,-5.87090601360233,-0.365905104207965,"GLB1L2","galactosidase beta 1 like 2",TRUE
+"1562888_at",0.860085676417428,0.47904934222193,0.720004565900537,-5.69029272149088,0.242489748910571,"GLB1L3","galactosidase beta 1 like 3",TRUE
+"1569886_a_at",0.912722788750542,0.634065898866154,-0.482668157754184,-5.82684571213099,-0.557333918312635,"GLB1L3","galactosidase beta 1 like 3",TRUE
+"225706_at",0.673322773608689,0.139071860950772,1.53446613681074,-4.85363770556417,0.885248636295309,"GLCCI1","glucocorticoid induced 1",TRUE
+"227525_at",0.787781415608703,0.313552473830259,1.03124413456638,-5.43457250816039,0.725518946686199,"GLCCI1","glucocorticoid induced 1",TRUE
+"1560316_s_at",0.803489780415187,0.341651167114602,0.971777829946813,-5.48990284783076,0.744724542240385,"GLCCI1","glucocorticoid induced 1",TRUE
+"225700_at",0.867159108376357,0.499141257608119,0.687112564317876,-5.71230911514319,0.42315559804921,"GLCCI1","glucocorticoid induced 1",TRUE
+"1560315_at",0.978255630670068,0.895007810753463,-0.133493961981042,-5.9310074307654,-0.0924228278206409,"GLCCI1","glucocorticoid induced 1",TRUE
+"213552_at",0.999868352720339,0.999575752928048,0.000537746244430718,-5.93968333990457,0.000258367349529109,"GLCE","glucuronic acid epimerase",TRUE
+"204836_at",0.895690630367785,0.576285031600981,-0.567193131786565,-5.78419450634347,-0.501309653747808,"GLDC","glycine decarboxylase",TRUE
+"232649_at",0.666643938027574,0.133497967398262,1.55759992262049,-4.82241895958249,0.640203456944919,"GLDN","gliomedin",TRUE
+"230360_at",0.830104575356196,0.401837715666328,-0.854749755808833,-5.5899669798667,-0.658174532169612,"GLDN","gliomedin",TRUE
+"225371_at",0.734577729521114,0.219130549035014,-1.26467053874341,-5.18932836134764,-0.383373992575414,"GLE1","GLE1, RNA export mediator",TRUE
+"206920_s_at",0.955730092376044,0.797721447716785,-0.259400187982033,-5.90696279277059,-0.0935373339680865,"GLE1","GLE1, RNA export mediator",TRUE
+"206921_at",0.982243328340126,0.914802240921949,-0.108211058345266,-5.93398175906377,-0.0454642921162138,"GLE1","GLE1, RNA export mediator",TRUE
+"207966_s_at",0.849303815076661,0.450197040119832,0.768684454517512,-5.65591606852515,0.249988609881326,"GLG1","golgi glycoprotein 1",TRUE
+"214730_s_at",0.86395116513843,0.490365792880017,0.70138315381375,-5.70287755896273,0.234465363523812,"GLG1","golgi glycoprotein 1",TRUE
+"212045_at",0.877948371309952,0.529606437109609,0.638636208842809,-5.74296060100207,0.373279581206182,"GLG1","golgi glycoprotein 1",TRUE
+"225918_at",0.991367768700244,0.959927062250948,0.0508165293930827,-5.93842580631887,0.0139386876753065,"GLG1","golgi glycoprotein 1",TRUE
+"206646_at",0.670164229230396,0.1360247978687,1.54701578227504,-4.83674795154209,1.15956640245542,"GLI1","GLI family zinc finger 1",TRUE
+"208057_s_at",0.744688669253745,0.236120793097701,1.21777237690863,-5.24209622227049,0.587826430355586,"GLI2","GLI family zinc finger 2",TRUE
+"207034_s_at",0.812302873476553,0.36075261519728,0.933245452530445,-5.52415348713694,1.02683210394756,"GLI2","GLI family zinc finger 2",TRUE
+"228537_at",0.925389506721126,0.676843460823356,0.422345020619115,-5.85317491676252,0.259218217581909,"GLI2","GLI family zinc finger 2",TRUE
+"1569342_at",0.627092759817312,0.0987626182762965,-1.7233039981586,-4.58829255613107,-1.96580590112676,"GLI3","GLI family zinc finger 3",TRUE
+"227376_at",0.698391916012681,0.169467026709084,-1.4202055961262,-5.00231258861121,-1.0572532307547,"GLI3","GLI family zinc finger 3",TRUE
+"205201_at",0.829393981329777,0.400612083272759,-0.857013756292826,-5.58814390288593,-0.387273287173274,"GLI3","GLI family zinc finger 3",TRUE
+"238364_x_at",0.897949253801113,0.5860270695414,-0.55266316190985,-5.79200164123603,-0.486113508849712,"GLI4","GLI family zinc finger 4",TRUE
+"243076_x_at",0.981140604770329,0.91087520711,0.113220678244292,-5.93344178457651,0.0498662742587497,"GLI4","GLI family zinc finger 4",TRUE
+"1555874_x_at",0.948764595648089,0.76691385652222,-0.300079447361063,-5.89591949882648,-0.177528992133873,"GLIDR","glioblastoma down-regulated RNA",TRUE
+"228040_at",0.963737076458538,0.834428931076129,-0.211501974252624,-5.91791910090247,-0.087558601318861,"GLIDR","glioblastoma down-regulated RNA",TRUE
+"204221_x_at",0.26338132901877,0.00395312752465099,3.21615174266821,-1.86542338844898,2.24498998236166,"GLIPR1","GLI pathogenesis related 1",TRUE
+"226136_at",0.502353736737413,0.0323785014771403,2.28299976639129,-3.67718521353413,2.22809832729257,"GLIPR1","GLI pathogenesis related 1",TRUE
+"214085_x_at",0.527546822913581,0.0400104172866301,2.18179871110785,-3.85413218757798,2.06887957973318,"GLIPR1","GLI pathogenesis related 1",TRUE
+"226142_at",0.533225267583674,0.0421166253116024,2.15697099679655,-3.896791733508,2.82173972113538,"GLIPR1","GLI pathogenesis related 1",TRUE
+"204222_s_at",0.62110896023334,0.0916626290090646,1.76315616879942,-4.52933096036338,2.8027927821001,"GLIPR1","GLI pathogenesis related 1",TRUE
+"238296_at",0.769258076576208,0.276178406190405,1.11648061755981,-5.3501248239808,0.316622574801072,"GLIPR1L1","GLI pathogenesis related 1 like 1",TRUE
+"225604_s_at",0.392585343378161,0.0133347180679884,2.68969816141833,-2.92220625424688,1.71250537580292,"GLIPR2","GLI pathogenesis related 2",TRUE
+"225602_at",0.640839095542136,0.111371798552197,1.65818579516606,-4.68245725255815,0.986357710192837,"GLIPR2","GLI pathogenesis related 2",TRUE
+"244128_x_at",0.836221360949212,0.417497465849206,0.826202782080724,-5.61256795407632,0.334269291819651,"GLIS1","GLIS family zinc finger 1",TRUE
+"223378_at",0.991367768700244,0.959755861718824,0.0510338256009821,-5.93841502813305,0.0308288774217367,"GLIS2","GLIS family zinc finger 2",TRUE
+"229435_at",0.78187900363728,0.303401398587884,1.05364338391734,-5.41296224682657,1.70283220853579,"GLIS3","GLIS family zinc finger 3",TRUE
+"230258_at",0.928295253101366,0.685404787028059,0.41046820587448,-5.85795258311976,0.437498104407451,"GLIS3","GLIS family zinc finger 3",TRUE
+"1553756_at",0.544717122899981,0.0467355834206458,-2.10622906102738,-3.9830215889393,-1.25405739021664,"GLIS3-AS1","GLIS3 antisense RNA 1",TRUE
+"207153_s_at",0.739340500562926,0.226615513178037,1.24368017600069,-5.21315790064781,0.399263328393696,"GLMN","glomulin, FKBP associated protein",TRUE
+"1558692_at",0.653206225743412,0.122470554981176,-1.60583066501437,-4.75615500688913,-0.883421443356823,"GLMP","glycosylated lysosomal membrane protein",TRUE
+"1558693_s_at",0.859486825765374,0.477162562584036,0.723134072679304,-5.6881469229287,0.32719401545558,"GLMP","glycosylated lysosomal membrane protein",TRUE
+"225401_at",0.899331416659389,0.589873135395946,0.546959989588641,-5.79501227496788,0.221827037593361,"GLMP","glycosylated lysosomal membrane protein",TRUE
+"200681_at",0.978197434639598,0.894293141968426,-0.134408356879923,-5.93088821873917,-0.0391143377250831,"GLO1","glyoxalase I",TRUE
+"209092_s_at",0.994825233837873,0.975850238879428,0.030615563069562,-5.93922696060229,0.0108685119002967,"GLOD4","glyoxalase domain containing 4",TRUE
+"231052_at",0.545324755084815,0.0469871956324566,-2.10359667639644,-3.98745939666157,-1.39417638739131,"GLOD5","glyoxalase domain containing 5",TRUE
+"241564_at",0.873298450403981,0.518014218061561,-0.656894712899329,-5.73166809061541,-0.414586890497613,"GLOD5","glyoxalase domain containing 5",TRUE
+"208391_s_at",0.615637099066718,0.085999633588308,1.79688944014003,-4.47864955150959,0.745747758543094,"GLP1R","glucagon like peptide 1 receptor",TRUE
+"208390_s_at",0.732074070325545,0.215766482379894,-1.27428389908236,-5.17830074161527,-0.608259790951469,"GLP1R","glucagon like peptide 1 receptor",TRUE
+"211232_x_at",0.837393127867504,0.421396139018771,0.819201410730819,-5.61800136129125,0.42210231300688,"GLP1R","glucagon like peptide 1 receptor",TRUE
+"208400_at",0.915569510513076,0.643887461853306,-0.468664860034109,-5.83326421227903,-0.320890439061234,"GLP1R","glucagon like peptide 1 receptor",TRUE
+"208401_s_at",0.976589025744684,0.888610728743945,-0.141683060395571,-5.92991085901093,-0.0976748683535771,"GLP1R","glucagon like peptide 1 receptor",TRUE
+"221312_at",0.0952827619788257,0.00040953724856011,4.15358474904337,0.130896818214801,2.17125120711732,"GLP2R","glucagon like peptide 2 receptor",TRUE
+"207972_at",0.398934416346185,0.0140603383706172,2.66606267257101,-2.96778374858112,1.19841445129676,"GLRA1","glycine receptor alpha 1",TRUE
+"207462_at",0.894272567245808,0.570584434750632,0.5757527752408,-5.77950338172902,0.500432250401203,"GLRA2","glycine receptor alpha 2",TRUE
+"216021_s_at",0.585036027492332,0.0651733155479804,-1.94031130445871,-4.25555398771909,-1.07559410057432,"GLRA3","glycine receptor alpha 3",TRUE
+"207928_s_at",0.657015752622694,0.125841875219575,1.5907148676789,-4.77709225994014,1.9879911559057,"GLRA3","glycine receptor alpha 3",TRUE
+"210661_at",0.947556859134482,0.760957047478314,0.308002798054284,-5.89358321885009,0.229178956314592,"GLRA3","glycine receptor alpha 3",TRUE
+"205280_at",0.835952408568777,0.416190478021703,0.82855911986633,-5.61072958486691,1.28228804968348,"GLRB","glycine receptor beta",TRUE
+"205279_s_at",0.890889721009079,0.559985496880092,0.5917843289266,-5.77053430353814,0.440152590275943,"GLRB","glycine receptor beta",TRUE
+"244680_at",0.95643295620889,0.802710136066686,-0.25285666238065,-5.90859026394813,-0.182359609225903,"GLRB","glycine receptor beta",TRUE
+"206662_at",0.968066640321622,0.849778072773497,0.191629046466293,-5.92181350971094,0.175102659214902,"GLRX","glutaredoxin",TRUE
+"209276_s_at",0.971106243538935,0.861535975292173,0.176459454058168,-5.92452870887491,0.130373829589624,"GLRX","glutaredoxin",TRUE
+"219933_at",0.662855903464759,0.130640250266646,-1.5697715702358,-4.80584570789988,-0.678077786994264,"GLRX2","glutaredoxin 2",TRUE
+"209080_x_at",0.71557775024401,0.191343841470515,1.34779744665831,-5.0916356243482,0.521473896036587,"GLRX3","glutaredoxin 3",TRUE
+"230095_at",0.816800680706682,0.367980440672273,0.919023739499985,-5.53647331432206,0.577833855537205,"GLRX3","glutaredoxin 3",TRUE
+"214205_x_at",0.821468803512885,0.383770431520986,0.888587422564435,-5.56225244341062,0.269274763893952,"GLRX3","glutaredoxin 3",TRUE
+"207506_at",0.928777626237599,0.686511392319949,-0.408937462664186,-5.85855860085386,-0.207227528505179,"GLRX3","glutaredoxin 3",TRUE
+"221932_s_at",0.575270671804438,0.0608095933502909,-1.97539739437351,-4.19917045872221,-0.766296945168497,"GLRX5","glutaredoxin 5",TRUE
+"221510_s_at",0.728671251879936,0.210186139149364,1.29048832328011,-5.15955130763151,1.29074117794534,"GLS","glutaminase",TRUE
+"223079_s_at",0.741260241503758,0.231822055462734,1.22938915319522,-5.22918560103426,1.39733717102062,"GLS","glutaminase",TRUE
+"241034_at",0.776074974591224,0.293521384735357,1.07596168156136,-5.39101590599021,1.07564125217202,"GLS","glutaminase",TRUE
+"211414_at",0.861659105448003,0.483083937037222,0.71333661463749,-5.69483518177719,0.517237315830329,"GLS","glutaminase",TRUE
+"223080_at",0.915639438262336,0.644347725618227,0.468010978117909,-5.83355940372485,0.218611522779747,"GLS","glutaminase",TRUE
+"203157_s_at",0.925511384407886,0.677846846762171,0.42094989347209,-5.85374307714746,0.237175661672685,"GLS","glutaminase",TRUE
+"203158_s_at",0.941106542715586,0.736105519880309,0.341283462920965,-5.88311177677413,0.194049933211042,"GLS","glutaminase",TRUE
+"203159_at",0.98273450122649,0.916122447060137,-0.106527547487469,-5.93415774178797,-0.0624307792238863,"GLS","glutaminase",TRUE
+"205531_s_at",0.806422472374043,0.347370196589438,-0.960091110295144,-5.50042490118574,-1.15134550843442,"GLS2","glutaminase 2",TRUE
+"1564706_s_at",0.846018332779732,0.444060980596484,-0.779276882713193,-5.6481543587994,-0.811505508195371,"GLS2","glutaminase 2",TRUE
+"1564705_at",0.915742010892393,0.644584720874056,-0.467674367355665,-5.833711207498,-0.564674266289574,"GLS2","glutaminase 2",TRUE
+"1564707_x_at",0.97897951922649,0.898037491608307,0.129618870652109,-5.93150361961485,0.128461594471796,"GLS2","glutaminase 2",TRUE
+"229770_at",0.862125670830879,0.484989731224045,0.710198170054263,-5.6969592837878,0.46712458593829,"GLT1D1","glycosyltransferase 1 domain containing 1",TRUE
+"218147_s_at",0.610198729812125,0.0827209777138404,-1.81730588021855,-4.4476369137871,-0.710527745235233,"GLT8D1","glycosyltransferase 8 domain containing 1",TRUE
+"218146_at",0.722869421140201,0.199296454581937,-1.32309517439462,-5.12121482500395,-0.607867892492433,"GLT8D1","glycosyltransferase 8 domain containing 1",TRUE
+"227070_at",0.540483367247649,0.0447885777615432,2.12704105208822,-3.94781121917019,2.54728276346674,"GLT8D2","glycosyltransferase 8 domain containing 2",TRUE
+"221447_s_at",0.56861088242915,0.0582727432110934,1.99683243395645,-4.16438776662719,1.4471567986212,"GLT8D2","glycosyltransferase 8 domain containing 2",TRUE
+"226177_at",0.820893155804534,0.38177725040325,-0.892383379362416,-5.55908114304531,-0.310085278198825,"GLTP","glycolipid transfer protein",TRUE
+"219267_at",0.979976490833035,0.904471579031369,-0.121396058647774,-5.9325081780231,-0.038818877564454,"GLTP","glycolipid transfer protein",TRUE
+"230971_x_at",0.955892698633978,0.799145897096005,-0.257530608736232,-5.90743200045003,-0.187525313981378,"GLTPD2","glycolipid transfer protein domain containing 2",TRUE
+"219445_at",0.819018525257656,0.374722320762401,-0.905924841734124,-5.54766619050138,-0.277495132138352,"GLTSCR1","glioma tumor suppressor candidate region gene 1",TRUE
+"38892_at",0.913627134030439,0.637708771219992,-0.477462977955462,-5.82925312542079,-0.2135737400103,"GLTSCR1L","GLTSCR1 like",TRUE
+"213208_at",0.938736647219162,0.726986504189369,-0.353592672431653,-5.87896985739329,-0.150422524013859,"GLTSCR1L","GLTSCR1 like",TRUE
+"234918_at",0.702888118552354,0.17481594643194,1.4018441264318,-5.02532924677709,0.891812822988789,"GLTSCR2","glioma tumor suppressor candidate region gene 2",TRUE
+"200946_x_at",0.929088231432081,0.687890399618254,0.40703130124918,-5.85931013105047,0.201050732783186,"GLUD1","glutamate dehydrogenase 1",TRUE
+"200947_s_at",0.957571530817866,0.809469629409475,0.244008329052431,-5.91072524722146,0.101846850441451,"GLUD1","glutamate dehydrogenase 1",TRUE
+"210447_at",0.523369751179323,0.0388285648481596,-2.19625374084802,-3.82915634964779,-2.23238490429561,"GLUD2","glutamate dehydrogenase 2",TRUE
+"215794_x_at",0.948962238903406,0.769583961123075,0.296534237560894,-5.89694529511145,0.13806753614241,"GLUD2","glutamate dehydrogenase 2",TRUE
+"215001_s_at",0.676432293600899,0.143154971545606,-1.51799933869577,-4.87563346720492,-1.48640774094369,"GLUL","glutamate-ammonia ligase",TRUE
+"200648_s_at",0.789661545166663,0.317436342731286,-1.02280922632544,-5.44260179400954,-1.13132188263842,"GLUL","glutamate-ammonia ligase",TRUE
+"242281_at",0.831943055644609,0.407998136110214,0.843436600371204,-5.59900947478865,0.585791288334953,"GLUL","glutamate-ammonia ligase",TRUE
+"217202_s_at",0.855075448726859,0.467392371607558,-0.739456773600753,-5.67681172045,-0.729503086289014,"GLUL","glutamate-ammonia ligase",TRUE
+"231683_at",0.821187434813103,0.382534553881073,0.890939590676568,-5.56028881941462,0.42647867179446,"GLYAT","glycine-N-acyltransferase",TRUE
+"206930_at",0.839519981963042,0.426829624240322,0.809511153023259,-5.62544995339111,0.473120661696444,"GLYAT","glycine-N-acyltransferase",TRUE
+"222083_at",0.965707350334601,0.839830194393396,0.204499300511886,-5.91933502101562,0.0608367929252935,"GLYAT","glycine-N-acyltransferase",TRUE
+"1562089_at",0.962905928655899,0.831794788514938,-0.214921014979041,-5.91721053635741,-0.16443760026514,"GLYATL1","glycine-N-acyltransferase like 1",TRUE
+"1554712_a_at",0.567651250567208,0.0577167070089038,-2.00164101232326,-4.15655024129524,-2.4009411854871,"GLYATL2","glycine-N-acyltransferase like 2",TRUE
+"242341_x_at",0.91050558382084,0.627591193234019,0.491953258538395,-5.82248797162593,0.311730804483101,"GLYCTK","glycerate kinase",TRUE
+"238518_x_at",0.968066640321622,0.849476015013991,-0.192019341000553,-5.92174070802194,-0.065957747536836,"GLYCTK","glycerate kinase",TRUE
+"242692_at",0.611042853196665,0.0834248057441604,1.81286483818245,-4.45440441566208,0.545913797926418,"GLYCTK-AS1","GLYCTK antisense RNA 1",TRUE
+"218506_x_at",0.443919401133943,0.0207032133606562,-2.49114359741302,-3.29892186096868,-0.700181990060532,"GLYR1","glyoxylate reductase 1 homolog",TRUE
+"222652_s_at",0.645740804644555,0.116700976476556,-1.63252565197025,-4.71880499309152,-0.448212569667147,"GLYR1","glyoxylate reductase 1 homolog",TRUE
+"221628_s_at",0.728385463227073,0.208770150115926,-1.2946529216328,-5.15470008450276,-0.505504265786522,"GLYR1","glyoxylate reductase 1 homolog",TRUE
+"222115_x_at",0.937623890519979,0.723836022850546,-0.357858193729605,-5.87750072663297,-0.10949832180696,"GLYR1","glyoxylate reductase 1 homolog",TRUE
+"212414_s_at",0.837337084923913,0.419945055071037,0.82180254284342,-5.61598781156892,0.753002344638522,"GLYR1///SEPT6","glyoxylate reductase 1 homolog///septin 6",TRUE
+"215891_s_at",0.760227035076299,0.258157586909904,1.16059921051433,-5.30408212988505,0.708002253345535,"GM2A","GM2 ganglioside activator",TRUE
+"215890_at",0.806221445484273,0.347031512401431,0.960779537028831,-5.49980830608261,0.422414674519679,"GM2A","GM2 ganglioside activator",TRUE
+"209727_at",0.811429110784149,0.355552335554473,0.943596243895676,-5.51507762782563,0.663317574362541,"GM2A","GM2 ganglioside activator",TRUE
+"33646_g_at",0.830592576740524,0.403241872098774,0.852161419891328,-5.59204572135677,0.491289630927438,"GM2A","GM2 ganglioside activator",TRUE
+"35820_at",0.844509386281136,0.441353551938304,0.783978967578304,-5.64467675630982,0.467463552779472,"GM2A","GM2 ganglioside activator",TRUE
+"212737_at",0.875600216502154,0.523021993063445,0.648979933241065,-5.73660074703802,0.384633318087609,"GM2A","GM2 ganglioside activator",TRUE
+"235678_at",0.879111461403304,0.532732642036805,0.633749657634212,-5.74593094023704,0.417468849577842,"GM2A","GM2 ganglioside activator",TRUE
+"239355_at",0.85492369444809,0.466969359711569,-0.740168012144697,-5.67631234611671,-0.197939994782191,"GMCL1","germ cell-less, spermatogenesis associated 1",TRUE
+"218458_at",0.993461753950386,0.969091942820734,0.0391873931095287,-5.93893554906586,0.0138923159732478,"GMCL1","germ cell-less, spermatogenesis associated 1",TRUE
+"234488_s_at",0.837368340567858,0.421319030502989,-0.819339489649118,-5.61789462401487,-0.25556647142702,"GMCL1P1///GMCL1","germ cell-less, spermatogenesis associated 1 pseudogene 1///germ cell-less, spermatogenesis associated 1",TRUE
+"214106_s_at",0.610033432202476,0.0822811320856444,1.82009787615901,-4.44337621063449,0.653815513075108,"GMDS","GDP-mannose 4,6-dehydratase",TRUE
+"204875_s_at",0.631316839203356,0.102454024045954,1.70354238997478,-4.61715742949729,0.698608078754903,"GMDS","GDP-mannose 4,6-dehydratase",TRUE
+"230357_at",0.657015752622694,0.125122849974225,1.59391015538136,-4.77267923505849,1.47966887815331,"GMDS","GDP-mannose 4,6-dehydratase",TRUE
+"233063_s_at",0.541879135605867,0.0453523351537713,2.12093246741716,-3.95816873899139,1.13775376076822,"GMDS-AS1","GMDS antisense RNA 1 (head to head)",TRUE
+"232335_at",0.616413638398853,0.0873287969474357,1.78880373785,-4.49086147927617,0.62986366332403,"GMDS-AS1","GMDS antisense RNA 1 (head to head)",TRUE
+"233062_at",0.638134354959023,0.109496427471713,1.66746212404115,-4.6692108261655,0.647710496602507,"GMDS-AS1","GMDS antisense RNA 1 (head to head)",TRUE
+"230613_at",0.707898177720919,0.179868219191125,-1.38490807093703,-5.04633980401698,-0.818871143374979,"GMEB1","glucocorticoid modulatory element binding protein 1",TRUE
+"235233_s_at",0.79983887115773,0.33525207883533,-0.985013992414614,-5.47784557498501,-0.278356392109583,"GMEB1","glucocorticoid modulatory element binding protein 1",TRUE
+"220938_s_at",0.902538209397152,0.601723641294835,0.529501039913693,-5.80403989122578,0.284440665545914,"GMEB1","glucocorticoid modulatory element binding protein 1",TRUE
+"235232_at",0.96261149778695,0.829932206569347,-0.217340172367446,-5.91670235497964,-0.0598037228969694,"GMEB1","glucocorticoid modulatory element binding protein 1",TRUE
+"44146_at",0.772719741774806,0.283295239577064,-1.09963673572451,-5.36728667591102,-0.267534076058551,"GMEB2","glucocorticoid modulatory element binding protein 2",TRUE
+"222251_s_at",0.864894115958506,0.49389165946697,-0.695632015917013,-5.70670079371218,-0.223299886674504,"GMEB2","glucocorticoid modulatory element binding protein 2",TRUE
+"202544_at",0.319095917986488,0.00703849432266491,-2.96971716606449,-2.36907323095437,-0.926472129057997,"GMFB","glia maturation factor beta",TRUE
+"202543_s_at",0.411110107932987,0.0161719498678799,-2.60329706387215,-3.08788458231321,-1.03929073859624,"GMFB","glia maturation factor beta",TRUE
+"204220_at",0.502394860388381,0.0324256425082409,2.28231049846678,-3.67840654812747,0.708610308925753,"GMFG","glia maturation factor gamma",TRUE
+"222782_s_at",0.899998627338565,0.594492090786635,0.540134873263891,-5.79857528098386,0.294057108016184,"GMIP","GEM interacting protein",TRUE
+"218913_s_at",0.940227139261806,0.732808368013812,-0.345727786564652,-5.8816330399861,-0.19856753557233,"GMIP","GEM interacting protein",TRUE
+"208000_at",0.938500267760216,0.726494473391557,-0.354258403711184,-5.87874171238499,-0.208067280370164,"GML","glycosylphosphatidylinositol anchored molecule like",TRUE
+"1569616_at",0.578925607036084,0.0618207304181414,1.96707399680214,-4.21260842146564,1.16554298702973,"GMNC","geminin coiled-coil domain containing",TRUE
+"218350_s_at",0.402463840838386,0.0148419946294261,2.64185498909536,-3.01426749055667,0.806365579055981,"GMNN","geminin, DNA replication inhibitor",TRUE
+"218070_s_at",0.976371465776674,0.88632162313702,0.144615795966793,-5.92950230547715,0.053537672394782,"GMPPA","GDP-mannose pyrophosphorylase A",TRUE
+"204187_at",0.877976372181159,0.529740512883114,0.638426315159634,-5.74308863787901,0.437352153284508,"GMPR","guanosine monophosphate reductase",TRUE
+"217990_at",0.831182446031643,0.405284026974837,-0.848407313710842,-5.5950502707814,-0.352393518901803,"GMPR2","guanosine monophosphate reductase 2",TRUE
+"236648_at",0.571736836402345,0.059769075209507,1.98409153992513,-4.1850929514852,0.800271052092725,"GMPS","guanine monophosphate synthase",TRUE
+"214431_at",0.615383570690161,0.0857316261169997,1.79853286229974,-4.47616258047844,0.588062379672673,"GMPS","guanine monophosphate synthase",TRUE
+"229333_at",0.95320966541231,0.784970556656411,0.276178656929042,-5.90260104333176,0.100223185852917,"GMPS","guanine monophosphate synthase",TRUE
+"214679_x_at",0.661974206478491,0.129761422951154,-1.57355903079498,-4.80066793358376,-0.526318786877891,"GNA11","G protein subunit alpha 11",TRUE
+"40562_at",0.740616728918811,0.23071937956952,-1.23239528077378,-5.2258274229679,-0.48153041090859,"GNA11","G protein subunit alpha 11",TRUE
+"213766_x_at",0.819193107051406,0.375610908951205,-0.904210061153107,-5.54912047339968,-0.336138911292194,"GNA11","G protein subunit alpha 11",TRUE
+"213944_x_at",0.835952408568777,0.417106907874823,-0.826906422214966,-5.61201950077975,-0.271461305493629,"GNA11","G protein subunit alpha 11",TRUE
+"564_at",0.854040699678541,0.46332258613268,-0.746315505389643,-5.67197710484823,-0.250630812190776,"GNA11","G protein subunit alpha 11",TRUE
+"204248_at",0.916042382946954,0.645754327583479,-0.466013945311941,-5.83445845504461,-0.205618840823883,"GNA11","G protein subunit alpha 11",TRUE
+"224681_at",0.868570766525613,0.504668607425435,0.678197162172335,-5.71810736850944,0.266501265801143,"GNA12","G protein subunit alpha 12",TRUE
+"221737_at",0.896115372949367,0.577614542263438,0.565202989988298,-5.78527544806762,0.185648936880817,"GNA12","G protein subunit alpha 12",TRUE
+"227539_at",0.876590919968167,0.525320524518719,0.64536105229656,-5.73883698478406,0.300236372515245,"GNA13","G protein subunit alpha 13",TRUE
+"206917_at",0.965119873295572,0.837749824457604,0.207195217422219,-5.9187955344653,0.1104860040977,"GNA13","G protein subunit alpha 13",TRUE
+"224761_at",0.967098323798013,0.846170930050924,0.196291912237326,-5.9209340935754,0.0882260123033394,"GNA13","G protein subunit alpha 13",TRUE
+"220108_at",0.552420073963858,0.0502281561530259,-2.07077476745158,-4.04249192720304,-1.53343457762487,"GNA14","G protein subunit alpha 14",TRUE
+"243580_at",0.901881761134427,0.599918386295345,-0.5321497978862,-5.80268860954548,-0.332034483063859,"GNA14","G protein subunit alpha 14",TRUE
+"1563171_at",0.894737148770801,0.572032551312265,0.573574283864416,-5.78070376503307,0.172818907385691,"GNA14-AS1","GNA14 antisense RNA 1",TRUE
+"205349_at",0.0817823743922019,0.000284200295098644,4.30265079782697,0.453017089121851,4.42467955257006,"GNA15","G protein subunit alpha 15",TRUE
+"209576_at",0.640046622433865,0.110344388899161,1.66325129521963,-4.67523078401206,2.481073713587,"GNAI1","G protein subunit alpha i1",TRUE
+"227692_at",0.690831353224561,0.160517997464377,1.45199244462027,-4.96188734476431,1.97019116368816,"GNAI1","G protein subunit alpha i1",TRUE
+"201040_at",0.940227139261806,0.732892052534026,0.345614898386793,-5.88167083479919,0.146458777188641,"GNAI2","G protein subunit alpha i2",TRUE
+"201179_s_at",0.961561244483099,0.825967973047407,0.222493434268366,-5.91560095666525,0.0828243955163508,"GNAI3","G protein subunit alpha i3",TRUE
+"201180_s_at",0.986844665519238,0.938387135949119,-0.0781793475397251,-5.93670698425036,-0.0234161482611714,"GNAI3","G protein subunit alpha i3",TRUE
+"201181_at",0.992376456171815,0.964371344740175,-0.045176471647488,-5.93868947587609,-0.02405399605993,"GNAI3","G protein subunit alpha i3",TRUE
+"214071_at",0.641581234599539,0.112041923719389,1.654903031114,-4.68713148479111,2.00655619434826,"GNAL","G protein subunit alpha L",TRUE
+"213924_at",0.725583196024696,0.204377976599954,1.30771168894659,-5.1394023548835,1.24990326724227,"GNAL","G protein subunit alpha L",TRUE
+"206355_at",0.910159094731364,0.62596621162506,0.494290443487038,-5.82137828980681,0.516083266731943,"GNAL","G protein subunit alpha L",TRUE
+"206356_s_at",0.996140682541913,0.980711084432666,-0.0244518402879965,-5.93939227355545,-0.0253080591181893,"GNAL","G protein subunit alpha L",TRUE
+"215912_at",0.762481923780801,0.2619702412112,-1.15108023008489,-5.31414913663685,-0.857068448728691,"GNAO1","G protein subunit alpha o1",TRUE
+"204762_s_at",0.851733415458562,0.456724991970688,0.757511056975014,-5.66399471721544,0.257404714554729,"GNAO1","G protein subunit alpha o1",TRUE
+"204763_s_at",0.913697616562839,0.638242573423133,0.476701371973681,-5.82960322954874,0.342291730314277,"GNAO1","G protein subunit alpha o1",TRUE
+"231951_at",0.943631120237335,0.747932294953912,-0.325398596986216,-5.88824234878189,-0.20052412684173,"GNAO1","G protein subunit alpha o1",TRUE
+"211426_x_at",0.923392984964514,0.671277566957193,-0.430099538135548,-5.84998324865448,-0.18004985068109,"GNAQ","G protein subunit alpha q",TRUE
+"224861_at",0.961212424803935,0.823571434680216,-0.225611769921086,-5.91492200577381,-0.161627031105986,"GNAQ","G protein subunit alpha q",TRUE
+"202615_at",0.985709215004606,0.931026548927627,-0.0875426828558911,-5.93595145389473,-0.0756642501698828,"GNAQ","G protein subunit alpha q",TRUE
+"224863_at",0.989942999001074,0.950953608294601,-0.0622097197366921,-5.93779869823864,-0.0497983115422862,"GNAQ","G protein subunit alpha q",TRUE
+"224862_at",0.993007207436969,0.966690578076048,-0.0422338352530845,-5.93881474512543,-0.0411726351340338,"GNAQ","G protein subunit alpha q",TRUE
+"217057_s_at",0.355028107426795,0.00953474935739167,-2.83776832375115,-2.63258467841168,-2.21781400942711,"GNAS","GNAS complex locus",TRUE
+"217673_x_at",0.567651250567208,0.0576496049947132,-2.00222408628743,-4.15559902793108,-0.931991856971031,"GNAS","GNAS complex locus",TRUE
+"211858_x_at",0.758991118684188,0.256578561438315,-1.16457203321732,-5.29985907217425,-0.315359544428507,"GNAS","GNAS complex locus",TRUE
+"214157_at",0.769847953580141,0.27847452340757,-1.1110121264645,-5.35572192053424,-0.868574386674471,"GNAS","GNAS complex locus",TRUE
+"229274_at",0.786455312223125,0.312144592258557,-1.034319874437,-5.43162987652726,-0.390858953490094,"GNAS","GNAS complex locus",TRUE
+"228173_at",0.819193107051406,0.375817479728769,-0.903811808592319,-5.54945786194678,-0.301326291975904,"GNAS","GNAS complex locus",TRUE
+"217058_at",0.835952408568777,0.41644834400502,0.82809385027521,-5.61109296741797,0.437555712601829,"GNAS","GNAS complex locus",TRUE
+"239037_at",0.835952408568777,0.417074441893248,0.826964932518366,-5.61197387516135,0.347779918138554,"GNAS","GNAS complex locus",TRUE
+"200981_x_at",0.871744769522775,0.513398017907622,-0.664228155030242,-5.7270465602323,-0.154821145732679,"GNAS","GNAS complex locus",TRUE
+"212273_x_at",0.876862063516282,0.525909572468025,-0.644435032361118,-5.73940727617959,-0.15671473592146,"GNAS","GNAS complex locus",TRUE
+"200780_x_at",0.904381089098038,0.60797188546111,-0.520362682621941,-5.808651487755,-0.121513755645458,"GNAS","GNAS complex locus",TRUE
+"214548_x_at",0.979588787486838,0.902248293779218,-0.12423643523093,-5.9321686064615,-0.0289353067852698,"GNAS","GNAS complex locus",TRUE
+"232881_at",0.986342822130003,0.935092482151846,0.0823695099872988,-5.93637942612808,0.11271798377355,"GNAS-AS1","GNAS antisense RNA 1",TRUE
+"214286_at",0.925511384407886,0.677578751111409,-0.421322575557784,-5.85359148463116,-0.195843767631353,"GNAT1","G protein subunit alpha transducin 1",TRUE
+"207514_s_at",0.972848610759081,0.868559727058493,0.167418090626066,-5.9260408911095,0.0475128469827788,"GNAT1","G protein subunit alpha transducin 1",TRUE
+"210604_at",0.919485127002411,0.658201944016626,0.44842377932828,-5.84221469250906,0.237116301066658,"GNAT2","G protein subunit alpha transducin 2",TRUE
+"216590_at",0.540483367247649,0.0449220730279992,2.12558833407243,-3.95027611320577,1.23612205872055,"GNAT3","G protein subunit alpha transducin 3",TRUE
+"204993_at",0.722937902375896,0.19958581572019,-1.32221101837188,-5.12226500319909,-0.694622740457135,"GNAZ","G protein subunit alpha z",TRUE
+"200746_s_at",0.783297797848606,0.305955331885777,1.04795857897154,-5.41848635536283,0.255789993407657,"GNB1","G protein subunit beta 1",TRUE
+"200745_s_at",0.816966928109267,0.369276013812223,0.91649426359759,-5.53864626953807,0.299237553971329,"GNB1","G protein subunit beta 1",TRUE
+"200744_s_at",0.903383391791809,0.603536645674109,0.526844764869215,-5.80538841673997,0.173607664496609,"GNB1","G protein subunit beta 1",TRUE
+"223563_at",0.819018525257656,0.374862424933704,0.905654293153389,-5.54789580828892,0.758902918015926,"GNB1L","G protein subunit beta 1 like",TRUE
+"223564_s_at",0.915742010892393,0.644627698918719,-0.467613330353182,-5.83373872233971,-0.405563510162804,"GNB1L","G protein subunit beta 1 like",TRUE
+"220762_s_at",0.967701855457407,0.848054865196055,-0.193856046237479,-5.92139612555154,-0.140853762449507,"GNB1L","G protein subunit beta 1 like",TRUE
+"200852_x_at",0.796378050779806,0.328760842686987,-0.998619678620428,-5.46529705221218,-0.392875671153663,"GNB2","G protein subunit beta 2",TRUE
+"206047_at",0.774011928861764,0.285615551109149,1.0942114699201,-5.37276498789127,0.425628739147252,"GNB3","G protein subunit beta 3",TRUE
+"223488_s_at",0.722937902375896,0.199537540453091,1.32235845604432,-5.12208992156995,1.2486329318592,"GNB4","G protein subunit beta 4",TRUE
+"223487_x_at",0.761222531335825,0.260242735358559,1.15538047583388,-5.30961033325466,1.92558896116861,"GNB4","G protein subunit beta 4",TRUE
+"225710_at",0.784918343662568,0.309716294145344,1.03964792290997,-5.42651372292798,2.02048647831132,"GNB4","G protein subunit beta 4",TRUE
+"1554346_at",0.820142510259395,0.378113072814057,0.899395766171885,-5.55318980398552,0.66158592239077,"GNB5","G protein subunit beta 5",TRUE
+"211871_x_at",0.839766955721852,0.428434190919916,0.806664250424567,-5.62762246975354,0.398219517276803,"GNB5","G protein subunit beta 5",TRUE
+"207124_s_at",0.912722788750542,0.634106098520962,0.482610644194172,-5.82687245180817,0.264398923837385,"GNB5","G protein subunit beta 5",TRUE
+"204000_at",0.980264692225439,0.907791475748118,0.117156592902476,-5.93300042473691,0.0499294079722858,"GNB5","G protein subunit beta 5",TRUE
+"242404_at",0.986342822130003,0.933954283560218,0.0838174258150759,-5.93626226570477,0.0530512346601864,"GNB5","G protein subunit beta 5",TRUE
+"205042_at",0.902770867950228,0.602313677586241,0.528636141568557,-5.80447970365357,0.607956084333638,"GNE","glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase",TRUE
+"201921_at",0.955816406528307,0.798607538155968,0.258237090231906,-5.90725509140364,0.194808992614865,"GNG10","G protein subunit gamma 10",TRUE
+"204115_at",0.777826511138126,0.296911757292838,1.06824342021713,-5.39865212460391,2.41356015725588,"GNG11","G protein subunit gamma 11",TRUE
+"239942_at",0.936318756756998,0.715954717554775,0.368558809097746,-5.87373866693717,0.36823110957426,"GNG11","G protein subunit gamma 11",TRUE
+"222834_s_at",0.647518308302168,0.118321858511063,1.62491641153416,-4.72949980706439,0.997465966298043,"GNG12","G protein subunit gamma 12",TRUE
+"1555240_s_at",0.683019114815084,0.152062587070495,1.48336932333036,-4.92127111473457,1.04437336521898,"GNG12","G protein subunit gamma 12",TRUE
+"212294_at",0.714883865555246,0.190674922933556,1.34991173222547,-5.08908260307744,0.929969092319089,"GNG12","G protein subunit gamma 12",TRUE
+"220806_x_at",0.827825169467994,0.396997630770749,-0.863716444643268,-5.58272027169148,-0.659660231896244,"GNG13","G protein subunit gamma 13",TRUE
+"1555766_a_at",0.707818577910656,0.179449607404438,-1.38629684720161,-5.04462487084933,-1.09696251633056,"GNG2","G protein subunit gamma 2",TRUE
+"224964_s_at",0.740681080735184,0.230997751572575,1.23163535229866,-5.22667701560338,1.713972443639,"GNG2","G protein subunit gamma 2",TRUE
+"224965_at",0.821462301526347,0.383714455402593,0.888693851095762,-5.56216369918708,0.65018069830727,"GNG2","G protein subunit gamma 2",TRUE
+"223943_s_at",0.839519981963042,0.428216814488696,0.807049541587396,-5.62732886840876,0.467821845928612,"GNG2","G protein subunit gamma 2",TRUE
+"222005_s_at",0.920835753388243,0.663358370978756,-0.441179251299557,-5.84532402485434,-0.109227308596267,"GNG3","G protein subunit gamma 3",TRUE
+"205184_at",0.708894565317004,0.181497937850411,1.37952567619509,-5.05297279420266,1.15146094434003,"GNG4","G protein subunit gamma 4",TRUE
+"1555867_at",0.784552021081681,0.308375073825583,1.04260340911722,-5.42366557012946,0.913706445460255,"GNG4","G protein subunit gamma 4",TRUE
+"1566513_a_at",0.821137675198948,0.382111343186281,0.891746204873877,-5.55961433936724,0.299120090434763,"GNG4","G protein subunit gamma 4",TRUE
+"1555765_a_at",0.821137675198948,0.382114627660804,0.891739942608704,-5.55961957796664,1.17267736569458,"GNG4","G protein subunit gamma 4",TRUE
+"207157_s_at",0.823773334423331,0.391023187725617,0.87488242228372,-5.57359784126035,0.253958574238123,"GNG5","G protein subunit gamma 5",TRUE
+"228831_s_at",0.660093442228076,0.128113090616065,-1.58072057883278,-4.79085078838336,-0.739342685635788,"GNG7","G protein subunit gamma 7",TRUE
+"206896_s_at",0.878278790222455,0.531048799041326,-0.636379724284056,-5.74433495422438,-0.609632154495852,"GNG7","G protein subunit gamma 7",TRUE
+"232043_at",0.911143250035311,0.629079350165002,0.48981530107337,-5.82349856152396,0.186098110100485,"GNG7","G protein subunit gamma 7",TRUE
+"234284_at",0.728825906537591,0.210360698802865,1.2899764261614,-5.16014668542432,0.637875351158372,"GNG8","G protein subunit gamma 8",TRUE
+"233416_at",0.940227139261806,0.732779954225298,0.345766117046315,-5.88162020421658,0.277235055016335,"GNG8","G protein subunit gamma 8",TRUE
+"207166_at",0.791211889207316,0.321312995033229,1.01446179875939,-5.45048913077679,1.24239156377025,"GNGT1","G protein subunit gamma transducin 1",TRUE
+"235139_at",0.845588139978284,0.443061053147418,0.781011445395232,-5.64687379373565,0.426007901407719,"GNGT2","G protein subunit gamma transducin 2",TRUE
+"239068_at",0.51470556386048,0.0348488673837035,2.24805776142407,-3.73882480285946,0.680892190327045,"GNL1","G protein nucleolar 1 (putative)",TRUE
+"203307_at",0.587626678796111,0.066445207853494,1.93047503355697,-4.27123663972773,0.533902669532841,"GNL1","G protein nucleolar 1 (putative)",TRUE
+"238487_at",0.657015752622694,0.125808852048723,1.59086128639965,-4.77689019133489,0.524980282956077,"GNL1","G protein nucleolar 1 (putative)",TRUE
+"228857_at",0.932974802426538,0.704112286648857,0.384720809550553,-5.86784921753659,0.12090251101706,"GNL1","G protein nucleolar 1 (putative)",TRUE
+"233544_at",0.966051687342135,0.841355283592596,0.202523948310229,-5.9197258464221,0.0543119583620326,"GNL1","G protein nucleolar 1 (putative)",TRUE
+"201948_at",0.919354071504066,0.65623762819943,-0.451189950327926,-5.8410143555482,-0.144034089112099,"GNL2","G protein nucleolar 2",TRUE
+"228395_at",0.930899509890345,0.694122794651447,-0.398435425380176,-5.86265623247329,-0.215748360972037,"GNL3","G protein nucleolar 3",TRUE
+"222109_at",0.839519981963042,0.42822350012286,-0.80703768975125,-5.62733790176182,-0.376680434253601,"GNL3L","G protein nucleolar 3 like",TRUE
+"217632_at",0.978072252406502,0.893739324031363,0.135117029155294,-5.93079526853197,0.0648610282386528,"GNL3L","G protein nucleolar 3 like",TRUE
+"205010_at",0.97897951922649,0.897945000135847,-0.129737140815469,-5.93148869150282,-0.0435031938768606,"GNL3L","G protein nucleolar 3 like",TRUE
+"46947_at",0.986342822130003,0.934886495255737,0.0826315348792098,-5.93635837516127,0.032257325417433,"GNL3L","G protein nucleolar 3 like",TRUE
+"205495_s_at",0.471106930308494,0.0255996102413632,2.39322468223858,-3.47915563186699,1.07558887919167,"GNLY","granulysin",TRUE
+"37145_at",0.937623890519979,0.723676451515187,0.358074421102634,-5.87742579019584,0.253452112889618,"GNLY","granulysin",TRUE
+"210328_at",0.552420073963858,0.0497106159303679,-2.07588618698166,-4.03395838643802,-2.12473003452073,"GNMT","glycine N-methyltransferase",TRUE
+"201956_s_at",0.992820830895496,0.966152177663765,0.0429169210666629,-5.93878641744028,0.0139096037316797,"GNPAT","glyceronephosphate O-acyltransferase",TRUE
+"202382_s_at",0.961212424803935,0.823478493042197,-0.225732749914313,-5.91489547547873,-0.0777359349516011,"GNPDA1","glucosamine-6-phosphate deaminase 1",TRUE
+"227022_at",0.822301440471208,0.387079509344444,0.882313747486047,-5.56746627094614,0.428472229761281,"GNPDA2","glucosamine-6-phosphate deaminase 2",TRUE
+"225853_at",0.849376388324004,0.450430783239622,-0.768282691362326,-5.65620849057987,-0.309266030729948,"GNPNAT1","glucosamine-phosphate N-acetyltransferase 1",TRUE
+"220398_at",0.896159990898752,0.578854585978081,-0.563348847722878,-5.78627920678961,-0.169939961797532,"GNPTAB","N-acetylglucosamine-1-phosphate transferase alpha and beta subunits",TRUE
+"240106_at",0.913233126230689,0.636095774560359,-0.479766076308119,-5.82819108347304,-0.156407763430944,"GNPTAB","N-acetylglucosamine-1-phosphate transferase alpha and beta subunits",TRUE
+"212959_s_at",0.988303773451367,0.944255341941426,-0.0707196252785145,-5.93724784232111,-0.0282972068255081,"GNPTAB","N-acetylglucosamine-1-phosphate transferase alpha and beta subunits",TRUE
+"224887_at",0.896159990898752,0.579171227844838,-0.562875717337094,-5.78653482848697,-0.24640927189475,"GNPTG","N-acetylglucosamine-1-phosphate transferase gamma subunit",TRUE
+"207987_s_at",0.763650705722297,0.263642811544839,1.14693664054301,-5.31850851576236,1.16871756017058,"GNRH1","gonadotropin releasing hormone 1",TRUE
+"235540_at",0.933400538871064,0.705269451993785,0.383137026835806,-5.86843736438953,0.246347668210578,"GNRH1","gonadotropin releasing hormone 1",TRUE
+"208519_x_at",0.926430328514448,0.680274127883208,-0.417578458661919,-5.85510845164708,-0.252348890305958,"GNRH2","gonadotropin releasing hormone 2",TRUE
+"211522_s_at",0.749589620061359,0.242499668062383,1.20082527468867,-5.26074033611575,0.931261095027592,"GNRHR","gonadotropin releasing hormone receptor",TRUE
+"211523_at",0.809411730389276,0.352621326963651,0.949475217595761,-5.50988189449633,0.772199127491822,"GNRHR","gonadotropin releasing hormone receptor",TRUE
+"216341_s_at",0.840130522756775,0.429154190582057,0.805388946670789,-5.62859334351017,0.304126867748308,"GNRHR","gonadotropin releasing hormone receptor",TRUE
+"1553067_a_at",0.358427723880268,0.00983851832722165,-2.82403058348674,-2.65973855805016,-1.20836007538222,"GNRHR2","gonadotropin releasing hormone receptor 2 (pseudogene)",TRUE
+"212335_at",0.526253358601247,0.0396468781903923,-2.18620339754082,-3.84653239546905,-0.811182010521858,"GNS","glucosamine (N-acetyl)-6-sulfatase",TRUE
+"203676_at",0.595419021493991,0.0721028408175913,-1.88863209013977,-4.33733148836637,-0.929304080421369,"GNS","glucosamine (N-acetyl)-6-sulfatase",TRUE
+"212334_at",0.750326501261927,0.243306008725547,-1.19870700518828,-5.26305476943056,-0.50413494928832,"GNS","glucosamine (N-acetyl)-6-sulfatase",TRUE
+"203384_s_at",0.635174103121116,0.106016712698803,-1.68503578475239,-4.64396227065893,-0.565443487589752,"GOLGA1","golgin A1",TRUE
+"203383_s_at",0.847717593536494,0.446766940242416,-0.774594796727428,-5.65159756622377,-0.243328100166963,"GOLGA1","golgin A1",TRUE
+"225672_at",0.779221878154977,0.300329997958113,-1.06052522656902,-5.40623905242133,-0.353130969812838,"GOLGA2","golgin A2",TRUE
+"204384_at",0.821424121108148,0.383162490748544,-0.889743857205403,-5.56128763582602,-0.307803173013379,"GOLGA2","golgin A2",TRUE
+"35436_at",0.840879524142924,0.430466147093946,-0.80306854875394,-5.63035613429439,-0.283533862222715,"GOLGA2","golgin A2",TRUE
+"211059_s_at",0.844727941869545,0.441622377510729,-0.783511301565879,-5.64502351915909,-0.219672561962001,"GOLGA2","golgin A2",TRUE
+"223326_s_at",0.985868869736215,0.931486052888946,-0.0869579262379998,-5.93600113577462,-0.0310130306397234,"GOLGA2P10","golgin A2 pseudogene 10",TRUE
+"223327_x_at",0.991249206045988,0.958965657803405,-0.0520368244131424,-5.938364682119,-0.0197923271886431,"GOLGA2P10","golgin A2 pseudogene 10",TRUE
+"234715_at",0.919354071504066,0.656472466550289,0.450859060588232,-5.84115832116742,0.320166935406834,"GOLGA2P3Y///GOLGA2P2Y","golgin A2 pseudogene 3, Y-linked///golgin A2 pseudogene 2, Y-linked",TRUE
+"233198_at",0.771011793494937,0.279893247825197,-1.10764963215285,-5.35915139044011,-0.572010505072786,"GOLGA2P5","golgin A2 pseudogene 5",TRUE
+"219876_s_at",0.841420204214686,0.432395772668182,-0.799663663468865,-5.6329341513617,-0.520898002782876,"GOLGA2P5","golgin A2 pseudogene 5",TRUE
+"232611_at",0.947062793209778,0.759659902012804,0.30973082807969,-5.89306567773728,0.157086782699404,"GOLGA2P5","golgin A2 pseudogene 5",TRUE
+"1554987_at",0.789224993491684,0.315476981524135,1.02705541572704,-5.43856723797621,0.278215096043817,"GOLGA3","golgin A3",TRUE
+"202106_at",0.822452640841017,0.38734623688443,-0.881809585981931,-5.56788377480857,-0.353383303240868,"GOLGA3","golgin A3",TRUE
+"226949_at",0.83030603167465,0.402540899266814,-0.85345282705964,-5.5910093022194,-0.252387140614424,"GOLGA3","golgin A3",TRUE
+"215203_at",0.920295529438727,0.660737235079794,0.444858797090452,-5.84375098245286,0.206569187635306,"GOLGA4","golgin A4",TRUE
+"201567_s_at",0.969859842767097,0.855860297258882,0.183776480040473,-5.92324688614869,0.0463682251284663,"GOLGA4","golgin A4",TRUE
+"218241_at",0.727822268767891,0.208069092488324,-1.29672291781412,-5.15228386639601,-0.424152789836825,"GOLGA5","golgin A5",TRUE
+"207575_at",0.719333457476224,0.195312518809066,1.33537148543975,-5.10657227966437,0.77884611278215,"GOLGA6A","golgin A6 family member A",TRUE
+"232813_s_at",0.975398143273847,0.882305128786363,-0.149764768493574,-5.92876480631811,-0.0887208421910399,"GOLGA6D///GOLGA6C///GOLGA6A///GOLGA6B","golgin A6 family member D///golgin A6 family member C///golgin A6 family member A///golgin A6 family member B",TRUE
+"1560790_at",0.962351204352784,0.828562637780036,0.219119840615543,-5.91632489330958,0.184814208368902,"GOLGA6L2","golgin A6 family-like 2",TRUE
+"1561170_at",0.678207122231248,0.14561451134655,1.5082653071497,-4.88854681651153,1.33421787849817,"GOLGA6L6","golgin A6 family-like 6",TRUE
+"1561171_a_at",0.872668627020452,0.51652482161525,0.659256841529903,-5.73018484939105,0.285125665420141,"GOLGA6L6///GOLGA6L22///GOLGA6L1","golgin A6 family-like 6///golgin A6 family-like 22///golgin A6 family-like 1",TRUE
+"217819_at",0.706731313427143,0.178560335869823,-1.38925563656765,-5.04096645538991,-0.646749614437841,"GOLGA7","golgin A7",TRUE
+"1554167_a_at",0.764312283028184,0.264337855466507,-1.14522045503296,-5.32031002586782,-0.529232053398188,"GOLGA7","golgin A7",TRUE
+"228068_at",0.96351240321323,0.833867288200708,-0.21223075275201,-5.91776901700579,-0.136850509320347,"GOLGA7B","golgin A7 family member B",TRUE
+"208797_s_at",0.522016286799917,0.0379910575281377,2.20674085749704,-3.81097310689442,0.907612633151296,"GOLGA8A","golgin A8 family member A",TRUE
+"208798_x_at",0.720198195589923,0.196268003919339,1.33240946680074,-5.11011563361392,1.20937321183049,"GOLGA8A","golgin A8 family member A",TRUE
+"222149_x_at",0.983567332578112,0.920082940869504,-0.101479045307367,-5.93466895068237,-0.0465534508887231,"GOLGA8DP///GOLGA8F///GOLGA8CP///GOLGA8EP///GOLGA8G","golgin A8 family member D, pseudogene///golgin A8 family member F///golgin A8 family member C, pseudogene///golgin A8 family member E, pseudogene///golgin A8 family member G",TRUE
+"1556739_at",0.812302873476553,0.358850065477595,0.937020636304436,-5.52085395153221,0.427901621022164,"GOLGA8M///GOLGA8IP","golgin A8 family member M///golgin A8 family member I, pseudogene",TRUE
+"213737_x_at",0.833956476774481,0.411802800243425,0.836503916131449,-5.60449512327643,0.405291633426396,"GOLGA8N","golgin A8 family member N",TRUE
+"201056_at",0.744307803443383,0.235260843360619,-1.2200833909725,-5.23953625842182,-0.427591708916081,"GOLGB1","golgin B1",TRUE
+"201057_s_at",0.90998880119877,0.625477085085686,-0.494994492602267,-5.821043004589,-0.165203865820633,"GOLGB1","golgin B1",TRUE
+"238002_at",0.617775129514679,0.0887368461517963,1.78035306634027,-4.50358173383462,0.919974105062558,"GOLIM4","golgi integral membrane protein 4",TRUE
+"204324_s_at",0.645740804644555,0.11689198772253,1.63162435766112,-4.72007377315163,1.36217937849666,"GOLIM4","golgi integral membrane protein 4",TRUE
+"204322_at",0.980221920594204,0.906985403984651,-0.118185731078743,-5.93288253684042,-0.038603231715336,"GOLIM4","golgi integral membrane protein 4",TRUE
+"1558248_at",0.470383336445939,0.0252591765122136,-2.3994450111268,-3.4678235290758,-1.08886023235727,"GOLM1","golgi membrane protein 1",TRUE
+"217771_at",0.998347572104896,0.992880360841983,-0.00902448971801546,-5.93964381371657,-0.0137192633782206,"GOLM1","golgi membrane protein 1",TRUE
+"217803_at",0.758436363256407,0.255495137553884,1.16730843001286,-5.29694296391357,0.338031956993802,"GOLPH3","golgi phosphoprotein 3",TRUE
+"218361_at",0.946941640414848,0.75906615929448,0.31052212058739,-5.89282772978251,0.110071737536444,"GOLPH3L","golgi phosphoprotein 3 like",TRUE
+"229372_at",0.894620113392961,0.571378772010648,-0.574557456816725,-5.78016256687814,-0.844573998244934,"GOLT1A","golgi transport 1A",TRUE
+"218193_s_at",0.603702127972549,0.07759226185137,1.85069490131868,-4.39637695518006,0.79662955219456,"GOLT1B","golgi transport 1B",TRUE
+"222552_at",0.718958043234793,0.194996411945656,1.33635392065459,-5.10539556853678,0.569339351809036,"GOLT1B","golgi transport 1B",TRUE
+"218873_at",0.936497309685708,0.716642307167628,-0.367623524911597,-5.8740718525004,-0.12185949623125,"GON4L","gon-4 like",TRUE
+"223555_at",0.959120911159536,0.814608097878654,-0.237295290477739,-5.91229457081063,-0.0847076520916961,"GON4L","gon-4 like",TRUE
+"1555913_at",0.962555471240652,0.829128383651445,0.218384602140083,-5.91648120637633,0.0731561379804262,"GON4L","gon-4 like",TRUE
+"219846_at",0.968733193320334,0.852662390404165,0.187903689544794,-5.92250097231439,0.0631176596331464,"GON4L","gon-4 like",TRUE
+"223273_at",0.538897778393305,0.0440974606407251,-2.13462488005046,-3.93492608918265,-1.08664541525862,"GON7","GON7, KEOPS complex subunit homolog",TRUE
+"227214_at",0.208428274543958,0.00238295874101962,3.42874773132674,-1.42129288548435,1.22679242549029,"GOPC","golgi associated PDZ and coiled-coil motif containing",TRUE
+"225023_at",0.380731642340006,0.0119347728271084,2.73894808060626,-2.82664087009048,0.99397055524409,"GOPC","golgi associated PDZ and coiled-coil motif containing",TRUE
+"225022_at",0.429170076412192,0.0187523074471694,2.5362986745687,-3.21452365634682,0.987627983126682,"GOPC","golgi associated PDZ and coiled-coil motif containing",TRUE
+"227215_at",0.500677386446044,0.0319720596765478,2.2889809098825,-3.6665779568429,0.935962655368582,"GOPC","golgi associated PDZ and coiled-coil motif containing",TRUE
+"236862_at",0.55937703282623,0.0532720107294846,2.04163266997765,-4.09088228549523,1.36797818537549,"GOPC","golgi associated PDZ and coiled-coil motif containing",TRUE
+"226337_at",0.789927874973432,0.319091018246792,-1.01923761188999,-5.44598370211109,-0.381269635864943,"GORAB","golgin, RAB6 interacting",TRUE
+"243677_at",0.769258076576208,0.276549917109753,1.1155935782972,-5.35103437909473,0.644455478229448,"GORASP1","golgi reassembly stacking protein 1",TRUE
+"215749_s_at",0.798428326317339,0.332882897202623,-0.989958564059193,-5.47330329962112,-0.331371027182392,"GORASP1","golgi reassembly stacking protein 1",TRUE
+"208843_s_at",0.539815385590521,0.0445576010090539,-2.12956382000399,-3.9435281877729,-0.581019191631393,"GORASP2","golgi reassembly stacking protein 2",TRUE
+"207812_s_at",0.809930331505913,0.353612347720493,-0.947483762296533,-5.51164522084173,-0.244352562983202,"GORASP2","golgi reassembly stacking protein 2",TRUE
+"208842_s_at",0.822010986888098,0.385805422178046,-0.884725125245654,-5.56546631216374,-0.214401784954358,"GORASP2","golgi reassembly stacking protein 2",TRUE
+"213020_at",0.64513208805899,0.116313998118283,-1.6343554266324,-4.71622750525666,-0.59706376676577,"GOSR1","golgi SNAP receptor complex member 1",TRUE
+"213021_at",0.702630084418366,0.174199894679235,-1.40393580909139,-5.02271971145363,-0.482047906023199,"GOSR1","golgi SNAP receptor complex member 1",TRUE
+"1555199_at",0.822010986888098,0.385836821661899,0.88466563518377,-5.56551571316648,0.767990592774724,"GOSR1","golgi SNAP receptor complex member 1",TRUE
+"204630_s_at",0.905522382178431,0.611830047415374,-0.514742308815547,-5.81144891825144,-0.225880640613848,"GOSR1","golgi SNAP receptor complex member 1",TRUE
+"239159_at",0.700466202059297,0.172177231180758,-1.41084515519126,-5.01407698473472,-1.02376007775748,"GOSR2","golgi SNAP receptor complex member 2",TRUE
+"213144_at",0.823074246722209,0.389161880309188,0.878383697926025,-5.57071494200942,0.315606812918134,"GOSR2","golgi SNAP receptor complex member 2",TRUE
+"213207_s_at",0.860755541530977,0.480653451092497,0.717349564272569,-5.69210622710852,0.243285737905829,"GOSR2","golgi SNAP receptor complex member 2",TRUE
+"213180_s_at",0.894538680437601,0.571146790953749,0.574906454368206,-5.77997024150222,0.17451051345898,"GOSR2","golgi SNAP receptor complex member 2",TRUE
+"213206_at",0.939647542340923,0.729341790614798,0.35040815328215,-5.88005532131338,0.120665956827471,"GOSR2","golgi SNAP receptor complex member 2",TRUE
+"210009_s_at",0.955752634534966,0.798248578284135,0.258708223260561,-5.90713684800085,0.0788390548361306,"GOSR2","golgi SNAP receptor complex member 2",TRUE
+"243880_at",0.990810941805126,0.955023186657175,-0.0570418064735979,-5.93809881473199,-0.0616093266601778,"GOSR2","golgi SNAP receptor complex member 2",TRUE
+"235041_at",0.99186228645105,0.962449420492175,-0.0476153120884509,-5.93857926281143,-0.0166813795046661,"GOSR2","golgi SNAP receptor complex member 2",TRUE
+"229255_x_at",0.998870448604467,0.995439046709971,-0.0057811822873433,-5.93966720210483,-0.00214908725044971,"GOSR2","golgi SNAP receptor complex member 2",TRUE
+"208813_at",0.889180786259992,0.556715805674477,0.596761498105573,-5.76770130898984,0.214613948006546,"GOT1","glutamic-oxaloacetic transaminase 1",TRUE
+"1553879_a_at",0.498730035869837,0.0313513513175058,2.29825090254455,-3.65010600363822,1.26889974429218,"GOT1L1","glutamic-oxaloacetic transaminase 1-like 1",TRUE
+"1553878_at",0.956938436670832,0.804625249153033,0.250347670947139,-5.90920332741988,0.104027295339106,"GOT1L1","glutamic-oxaloacetic transaminase 1-like 1",TRUE
+"200708_at",0.994943851647199,0.976157118079292,0.0302263960864066,-5.93923849261365,0.0107169716301918,"GOT2","glutamic-oxaloacetic transaminase 2",TRUE
+"207389_at",0.748437803638032,0.240978492825677,1.20483588567056,-5.25634859679321,0.32293934278474,"GP1BA","glycoprotein Ib platelet alpha subunit",TRUE
+"206681_x_at",0.840279074575527,0.429399128370192,0.804955402258207,-5.62892306720222,0.610825043352141,"GP2","glycoprotein 2",TRUE
+"214325_at",0.942285214854475,0.74007030453133,-0.335948474520417,-5.88486187204356,-0.136155128474458,"GP2","glycoprotein 2",TRUE
+"214324_at",0.948109877411639,0.764165374893422,-0.303732827110047,-5.8948497602171,-0.268530129524414,"GP2","glycoprotein 2",TRUE
+"208473_s_at",0.982844899319041,0.916541652623812,-0.105993047838238,-5.93421303825747,-0.091870428595171,"GP2","glycoprotein 2",TRUE
+"207926_at",0.855848267496036,0.469209909797781,-0.736405153196532,-5.67894915296834,-0.380954193781084,"GP5","glycoprotein V platelet",TRUE
+"211525_s_at",0.867436259435403,0.499795432794516,0.686054498024445,-5.71300102785124,0.552929904158566,"GP5","glycoprotein V platelet",TRUE
+"220336_s_at",0.617775129514679,0.0888268783569834,1.77981665935734,-4.50438766894172,0.839552407025283,"GP6","glycoprotein VI platelet",TRUE
+"206883_x_at",0.979616296735197,0.90312828629601,0.123112069621891,-5.93230396386814,0.0921295639687756,"GP9","glycoprotein IX platelet",TRUE
+"205929_at",0.823368330423456,0.390217104306037,0.876397400643747,-5.57235174203919,0.591098739014266,"GPA33","glycoprotein A33",TRUE
+"211060_x_at",0.88113080359582,0.537611991706038,0.626153643783577,-5.75050466688611,0.312848488157524,"GPAA1","glycosylphosphatidylinositol anchor attachment 1",TRUE
+"201618_x_at",0.884769004468037,0.544715939546403,0.615160245729197,-5.75702995730302,0.300819615413952,"GPAA1","glycosylphosphatidylinositol anchor attachment 1",TRUE
+"215690_x_at",0.932091525948902,0.700616032061183,0.389512156433291,-5.86605536226657,0.189423992567587,"GPAA1","glycosylphosphatidylinositol anchor attachment 1",TRUE
+"220171_x_at",0.808257777979515,0.35070741061174,0.953331974146611,-5.50645730008696,0.427953235998295,"GPALPP1","GPALPP motifs containing 1",TRUE
+"229891_x_at",0.887929552412429,0.553342279169875,-0.601912716081298,-5.76474510881538,-0.212345425216446,"GPALPP1","GPALPP motifs containing 1",TRUE
+"223606_x_at",0.957430653957785,0.807503973584948,-0.246579333497907,-5.91011268983496,-0.0951078052935515,"GPALPP1","GPALPP motifs containing 1",TRUE
+"229078_s_at",0.972819824894874,0.86846232827072,0.167543368355329,-5.92602047997418,0.0735849795855748,"GPALPP1","GPALPP motifs containing 1",TRUE
+"226429_at",0.981335195954425,0.911581465195126,0.112319507165424,-5.93354071965441,0.0402597820177597,"GPALPP1","GPALPP motifs containing 1",TRUE
+"225420_at",0.927369128478015,0.682004303373982,0.415178290036367,-5.85607390061221,0.182822635234301,"GPAM","glycerol-3-phosphate acyltransferase, mitochondrial",TRUE
+"225424_at",0.976371465776674,0.886549036793623,0.144324382520466,-5.92954327548765,0.0535014417623945,"GPAM","glycerol-3-phosphate acyltransferase, mitochondrial",TRUE
+"225476_at",0.686108994812404,0.154509101301881,1.47414810028056,-4.93328053388436,0.552193786075929,"GPANK1","G-patch domain and ankyrin repeats 1",TRUE
+"225472_at",0.892625092437988,0.564970012200968,0.584225695009718,-5.77479278174678,0.216195428500548,"GPANK1","G-patch domain and ankyrin repeats 1",TRUE
+"235557_at",0.892780783477555,0.565933463632838,-0.582768662121397,-5.77560757503053,-1.07215254700957,"GPAT2","glycerol-3-phosphate acyltransferase 2, mitochondrial",TRUE
+"224480_s_at",0.621503477846441,0.0919040808118605,1.76175815116654,-4.53141617476378,2.57158210825671,"GPAT3","glycerol-3-phosphate acyltransferase 3",TRUE
+"224776_at",0.687042809569009,0.155717137561576,-1.4696385210976,-4.93913162855756,-0.763424575012058,"GPAT4","glycerol-3-phosphate acyltransferase 4",TRUE
+"229577_at",0.861659105448003,0.482914084114327,-0.713616675158487,-5.69464520321318,-0.36224924871269,"GPAT4","glycerol-3-phosphate acyltransferase 4",TRUE
+"236743_at",0.93474377881867,0.710183021824886,0.376422992051769,-5.87090408941697,0.346733456761964,"GPAT4","glycerol-3-phosphate acyltransferase 4",TRUE
+"219818_s_at",0.841967750949524,0.43451892100315,-0.795928149109096,-5.63575065874192,-0.209576039737994,"GPATCH1","G-patch domain containing 1",TRUE
+"1559893_at",0.535243600695458,0.0428285133697451,2.14883290157185,-3.91070850845175,0.877272179547733,"GPATCH11","G-patch domain containing 11",TRUE
+"228495_at",0.998870448604467,0.996416710165938,0.00454194643972685,-5.93967343299364,0.00135650212024174,"GPATCH11","G-patch domain containing 11",TRUE
+"236026_at",0.365243500989124,0.0107026323335153,-2.78705014075899,-2.73255441146006,-1.63121950564731,"GPATCH2","G-patch domain containing 2",TRUE
+"242224_at",0.432151440378733,0.0193400886221365,-2.52224980262352,-3.24086604845495,-1.17285511320155,"GPATCH2","G-patch domain containing 2",TRUE
+"219078_at",0.896345073598643,0.580448303265364,-0.560968810269083,-5.78756297564127,-0.209755460170806,"GPATCH2","G-patch domain containing 2",TRUE
+"239768_x_at",0.915353407558177,0.64301583179174,-0.469903725534015,-5.83270382678036,-0.2193568998635,"GPATCH2","G-patch domain containing 2",TRUE
+"243704_at",0.942324052902057,0.741001926483238,-0.334696337168114,-5.8852686727518,-0.177142912425348,"GPATCH2","G-patch domain containing 2",TRUE
+"231970_at",0.809707978333974,0.353100221707686,-0.948512407320868,-5.51073483477387,-0.354069725549633,"GPATCH2L","G-patch domain containing 2 like",TRUE
+"229297_at",0.834265235157814,0.412236744262112,-0.83571579078868,-5.60511606813884,-0.261724245678108,"GPATCH2L","G-patch domain containing 2 like",TRUE
+"229514_at",0.864280748950698,0.491600676938596,0.699366210038749,-5.70422179913619,0.268884990848447,"GPATCH2L","G-patch domain containing 2 like",TRUE
+"235302_at",0.896159990898752,0.578958179592719,0.56319404250306,-5.78636286749217,0.15433630638752,"GPATCH2L","G-patch domain containing 2 like",TRUE
+"229673_at",0.902681832009074,0.602030676271088,0.529050925026144,-5.80426886802384,0.173487384015891,"GPATCH2L","G-patch domain containing 2 like",TRUE
+"219720_s_at",0.945498722604777,0.754002466351737,-0.317278888765958,-5.89077142358389,-0.0942830182483831,"GPATCH2L","G-patch domain containing 2 like",TRUE
+"229520_s_at",0.973515224681688,0.872603166146402,0.162219672260728,-5.92687442831348,0.0661727764042919,"GPATCH2L","G-patch domain containing 2 like",TRUE
+"239478_x_at",0.989524702314661,0.948575665428327,0.0652302380612568,-5.93761124743017,0.0247902498559469,"GPATCH2L","G-patch domain containing 2 like",TRUE
+"218895_at",0.952293443370532,0.781580390509905,0.280653121567884,-5.90139203217588,0.0778694955525285,"GPATCH3","G-patch domain containing 3",TRUE
+"224634_at",0.620912785033482,0.0906841380739388,-1.76885425710759,-4.5208194063436,-0.660493315192697,"GPATCH4","G-patch domain containing 4",TRUE
+"224632_at",0.623852759019384,0.0955239551895205,-1.74116770426662,-4.56198650902761,-0.676533331981217,"GPATCH4","G-patch domain containing 4",TRUE
+"220596_at",0.837609393049242,0.422029511837595,-0.818067823218197,-5.6188770057414,-0.205458699193657,"GPATCH4","G-patch domain containing 4",TRUE
+"224633_s_at",0.839519981963042,0.426392766968713,0.810287401019751,-5.6248563398617,0.235707606952068,"GPATCH4","G-patch domain containing 4",TRUE
+"221733_s_at",0.980009054680439,0.905401664625713,0.120208124831724,-5.93264787164113,0.0661445723804839,"GPATCH4","G-patch domain containing 4",TRUE
+"212487_at",0.770807031642694,0.279325205911873,1.10899444826991,-5.35778089444857,0.298163065773361,"GPATCH8","G-patch domain containing 8",TRUE
+"212485_at",0.816800680706682,0.368567056530219,0.917877698662647,-5.53745850860329,0.239907111926202,"GPATCH8","G-patch domain containing 8",TRUE
+"1552501_a_at",0.591331966259927,0.0687498918251443,-1.91306610213423,-4.29885791852964,-1.00728539323854,"GPBAR1","G protein-coupled bile acid receptor 1",TRUE
+"223705_s_at",0.680894066852985,0.148769282535451,-1.49597476893306,-4.9047566572426,-0.447968467768696,"GPBP1","GC-rich promoter binding protein 1",TRUE
+"224648_at",0.864079461576774,0.491122287654493,-0.700147220602062,-5.70370171407042,-0.268671819977932,"GPBP1","GC-rich promoter binding protein 1",TRUE
+"1569320_at",0.937970117310484,0.725620888008807,0.355440791268986,-5.87833546494887,0.205552223865383,"GPBP1L1","GC-rich promoter binding protein 1 like 1",TRUE
+"217877_s_at",0.962435044681084,0.828799276295002,-0.218812292228868,-5.9163903422926,-0.0626013679596493,"GPBP1L1","GC-rich promoter binding protein 1 like 1",TRUE
+"222452_s_at",0.996455602606062,0.982586325722967,-0.0220742413945231,-5.93944615124545,-0.00612381376662086,"GPBP1L1","GC-rich promoter binding protein 1 like 1",TRUE
+"202755_s_at",0.62179111032845,0.0921906112093747,1.76010321125645,-4.53388302933571,0.88158796049644,"GPC1","glypican 1",TRUE
+"202756_s_at",0.845566619252464,0.442862883489485,0.781355491827945,-5.64661947767227,0.408598836821788,"GPC1","glypican 1",TRUE
+"239422_at",0.593339168375633,0.0705064526887603,1.90013840756257,-4.31925673567233,0.897251383598806,"GPC2","glypican 2",TRUE
+"243243_at",0.697172073261335,0.166951484374411,1.42900168055755,-4.99119931997903,0.881752035236066,"GPC3","glypican 3",TRUE
+"209220_at",0.945509858471469,0.754471039879163,-0.316653016687417,-5.89096373934014,-0.245489084289107,"GPC3","glypican 3",TRUE
+"204984_at",0.885312914741353,0.54675165347641,-0.612024056314775,-5.75887106221231,-0.608755108552383,"GPC4","glypican 4",TRUE
+"204983_s_at",0.954672574687803,0.793528001675017,0.264909571180945,-5.90556049734779,0.223727669144491,"GPC4","glypican 4",TRUE
+"207174_at",0.822173415758858,0.386563666882983,-0.883289422562047,-5.56665767098252,-1.29826258202864,"GPC5","glypican 5",TRUE
+"223730_at",0.632826839028712,0.103567161511274,-1.69770222087417,-4.62564009140915,-1.76959147209444,"GPC6","glypican 6",TRUE
+"227059_at",0.687734660055697,0.156947161499753,-1.46507591967602,-4.9450367511665,-2.34764132144202,"GPC6","glypican 6",TRUE
+"224826_at",0.865187396415238,0.494441440687006,-0.694737374377883,-5.70729283291403,-0.395341455961534,"GPCPD1","glycerophosphocholine phosphodiesterase 1",TRUE
+"230492_s_at",0.926030376684665,0.679241375885904,-0.419012322424958,-5.85452908013008,-0.282316950255733,"GPCPD1","glycerophosphocholine phosphodiesterase 1",TRUE
+"224835_at",0.995623666221824,0.979161508142231,-0.0264166403207002,-5.93934359487277,-0.0140455291105557,"GPCPD1","glycerophosphocholine phosphodiesterase 1",TRUE
+"1563035_x_at",0.642021982677251,0.112330176459373,1.65349604599277,-4.6891326854613,1.17386852362875,"GPD1","glycerol-3-phosphate dehydrogenase 1",TRUE
+"1563034_at",0.722288531465626,0.198650429222766,1.32507275752537,-5.11886376027838,0.690729469145603,"GPD1","glycerol-3-phosphate dehydrogenase 1",TRUE
+"204997_at",0.875279162021058,0.522526051181844,0.649761902936548,-5.73611596210145,0.260307226558891,"GPD1","glycerol-3-phosphate dehydrogenase 1",TRUE
+"213706_at",0.94895689004559,0.768251019527965,0.298303552140791,-5.89643485986262,0.134168815958897,"GPD1","glycerol-3-phosphate dehydrogenase 1",TRUE
+"212510_at",0.703902004301726,0.175565570151088,-1.39930684136535,-5.02849039573059,-1.01455723984334,"GPD1L","glycerol-3-phosphate dehydrogenase 1-like",TRUE
+"211613_s_at",0.828607509614823,0.39891077810004,0.860163810318122,-5.58559986428908,0.307699373927871,"GPD2","glycerol-3-phosphate dehydrogenase 2",TRUE
+"210007_s_at",0.969680817980507,0.855305480163291,0.184492289184321,-5.923118700866,0.0732718256557359,"GPD2","glycerol-3-phosphate dehydrogenase 2",TRUE
+"225447_at",0.985498770484702,0.930086181423808,0.0887394756449444,-5.93584873508548,0.0321712076508138,"GPD2","glycerol-3-phosphate dehydrogenase 2",TRUE
+"210640_s_at",0.774230543658252,0.288105196210914,-1.08842556860039,-5.37858087640035,-1.17413607943611,"GPER1","G protein-coupled estrogen receptor 1",TRUE
+"211829_s_at",0.82064687791745,0.381443336840713,-0.893020577475434,-5.55854757437997,-1.25227812964791,"GPER1","G protein-coupled estrogen receptor 1",TRUE
+"237230_at",0.406795337445118,0.0154533866643532,2.62374263049514,-3.04891403239511,0.883512546438679,"GPHA2","glycoprotein hormone alpha 2",TRUE
+"1553945_at",0.954672574687803,0.793581214194005,0.264839608008415,-5.90557848848533,0.159108474670012,"GPHB5","glycoprotein hormone beta 5",TRUE
+"220773_s_at",0.612420348961838,0.0841745081624083,-1.80816985581383,-4.46154588583675,-1.16669842606178,"GPHN","gephyrin",TRUE
+"234941_s_at",0.689848451630875,0.158920588745811,-1.45781591331974,-4.95440228331239,-0.646543631591237,"GPHN","gephyrin",TRUE
+"223319_at",0.695439932196858,0.164886007434629,-1.4363039487869,-4.98193072277103,-1.05060083213258,"GPHN","gephyrin",TRUE
+"208308_s_at",0.972112264314695,0.866285709407036,-0.170343731787613,-5.92556025081737,-0.0553059324200937,"GPI","glucose-6-phosphate isomerase",TRUE
+"238062_at",0.825128306715579,0.392560356914232,0.871999026286794,-5.5759639589185,0.576098157331836,"GPIHBP1","glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1",TRUE
+"203776_at",0.74371414757151,0.234454258543094,-1.22225680809951,-5.23712488350608,-0.369410056316026,"GPKOW","G-patch domain and KOW motifs",TRUE
+"206265_s_at",0.75710709622615,0.252864059468034,1.17398981110724,-5.28979761634459,0.991225771114384,"GPLD1","glycosylphosphatidylinositol specific phospholipase D1",TRUE
+"206264_at",0.775121983908223,0.291537002590045,-1.08050885982131,-5.38649406723774,-0.375802945710835,"GPLD1","glycosylphosphatidylinositol specific phospholipase D1",TRUE
+"215554_at",0.784925710185113,0.310033638263362,-1.03894995257484,-5.4271852828165,-0.959883957763361,"GPLD1","glycosylphosphatidylinositol specific phospholipase D1",TRUE
+"238752_at",0.854116828440652,0.463612914691971,0.745825036535188,-5.67232423337929,0.689875299959097,"GPLD1","glycosylphosphatidylinositol specific phospholipase D1",TRUE
+"217405_x_at",0.937623890519979,0.723625546338059,0.35814340389759,-5.87740187389502,0.150500899648135,"GPLD1","glycosylphosphatidylinositol specific phospholipase D1",TRUE
+"206266_at",0.984161165881616,0.922588595765974,0.0982864519547549,-5.93497943559181,0.0502753055947065,"GPLD1","glycosylphosphatidylinositol specific phospholipase D1",TRUE
+"209469_at",0.776696310319783,0.294100448963887,1.07463892359387,-5.39232809354709,1.47439767583238,"GPM6A","glycoprotein M6A",TRUE
+"236024_at",0.978928101156583,0.897153681961172,0.130749088292639,-5.9313604073432,0.0879394709855283,"GPM6A","glycoprotein M6A",TRUE
+"209470_s_at",0.980832655742,0.910111139169266,0.114195721724819,-5.93333385003804,0.128037759813713,"GPM6A","glycoprotein M6A",TRUE
+"209167_at",0.750042714158968,0.242964789241294,1.1996027494006,-5.26207650762545,1.3453518410852,"GPM6B","glycoprotein M6B",TRUE
+"209168_at",0.816800680706682,0.367952858070216,0.919077656105901,-5.53642693699971,0.329645747370289,"GPM6B","glycoprotein M6B",TRUE
+"209170_s_at",0.949613960042259,0.772271352268749,0.292969988866676,-5.89796441401351,0.316588728928195,"GPM6B","glycoprotein M6B",TRUE
+"209169_at",0.968310132926227,0.85120969215973,-0.189779637137177,-5.92215647341832,-0.186845906325865,"GPM6B","glycoprotein M6B",TRUE
+"209313_at",0.580137756009815,0.0626016664785195,1.96072754343923,-4.2228287433385,0.645199521702301,"GPN1","GPN-loop GTPase 1",TRUE
+"218799_at",0.889389445320988,0.557075163273018,-0.596213736864986,-5.76801421641505,-0.210083045609958,"GPN2","GPN-loop GTPase 2",TRUE
+"235058_at",0.943294768503521,0.745032562945195,-0.32928525274522,-5.88700937176686,-0.10476889971363,"GPN2","GPN-loop GTPase 2",TRUE
+"218461_at",0.932830928398943,0.703663400099077,-0.385335458714742,-5.86762031977713,-0.105294806417172,"GPN3","GPN-loop GTPase 3",TRUE
+"201141_at",0.40221114169538,0.0145899957216501,2.64952547066477,-2.99956042290078,3.21283104435245,"GPNMB","glycoprotein nmb",TRUE
+"1554018_at",0.585036027492332,0.065143587555194,1.9405432233511,-4.25518356213797,2.93735754084587,"GPNMB","glycoprotein nmb",TRUE
+"214605_x_at",0.740476003158683,0.229290841194676,1.23630604952678,-5.22144807697494,1.37170776418503,"GPR1","G protein-coupled receptor 1",TRUE
+"232799_at",0.182644973816866,0.00172706815662222,3.56262554210981,-1.13809350577969,2.87929858216488,"GPR1-AS","GPR1 antisense RNA",TRUE
+"1553544_at",0.731492530402354,0.214722850256905,1.27728966740579,-5.17483815215642,0.860892915567633,"GPR101","G protein-coupled receptor 101",TRUE
+"220264_s_at",0.837548264373422,0.421509283343408,0.818998830838415,-5.61815792837259,0.623919434799594,"GPR107","G protein-coupled receptor 107",TRUE
+"211979_at",0.930499673921727,0.692505951328195,-0.400662457168573,-5.86179606854235,-0.169300592612432,"GPR107","G protein-coupled receptor 107",TRUE
+"211977_at",0.931560290412494,0.697490326632213,-0.393803563694657,-5.86443010855669,-0.123970224834808,"GPR107","G protein-coupled receptor 107",TRUE
+"220265_at",0.951684340070943,0.778527617741893,-0.284687292785105,-5.90028545987842,-0.145157816517369,"GPR107","G protein-coupled receptor 107",TRUE
+"1559603_at",0.615637099066718,0.0857860096046941,1.79819902432853,-4.4766679070151,1.19470886542147,"GPR12","G protein-coupled receptor 12",TRUE
+"214558_at",0.994943851647199,0.976290477368546,-0.0300572788130658,-5.93924345801005,-0.0182592502067651,"GPR12","G protein-coupled receptor 12",TRUE
+"221140_s_at",0.670152406964446,0.135889963835589,1.54757644425833,-4.83599085294049,0.719473541520661,"GPR132","G protein-coupled receptor 132",TRUE
+"223887_at",0.969946179106301,0.857641364631409,0.181479259791522,-5.92365491158983,0.117383803276999,"GPR132","G protein-coupled receptor 132",TRUE
+"217641_at",0.634202341398092,0.105272481184614,-1.68885766262838,-4.63844477217807,-1.1249064876017,"GPR135","G protein-coupled receptor 135",TRUE
+"214503_x_at",0.776936981479994,0.295253671086501,-1.07201016405668,-5.3949315623714,-0.397145699150743,"GPR135","G protein-coupled receptor 135",TRUE
+"241085_at",0.897949253801113,0.58596234608259,0.552759295865937,-5.79195063341764,0.36406368740881,"GPR135","G protein-coupled receptor 135",TRUE
+"211659_at",0.925511384407886,0.678282237348946,-0.420344782358947,-5.85398893181514,-0.163590551620706,"GPR135","G protein-coupled receptor 135",TRUE
+"43934_at",0.308861881799719,0.0064612531188436,-3.00660480267679,-2.29458122865921,-1.07641971636166,"GPR137","G protein-coupled receptor 137",TRUE
+"221966_at",0.48580305784244,0.0284128744406717,-2.34455902786371,-3.56724467285509,-1.71426281207266,"GPR137","G protein-coupled receptor 137",TRUE
+"219430_at",0.734577729521114,0.219085180306696,-1.26479943053219,-5.18918098003737,-0.682618386714092,"GPR137","G protein-coupled receptor 137",TRUE
+"204137_at",0.831943055644609,0.408006823402251,-0.843420724058559,-5.5990220855865,-0.829180147452449,"GPR137B","G protein-coupled receptor 137B",TRUE
+"242592_at",0.508488499910913,0.0336177088902408,-2.26517853470087,-3.70869326144017,-1.08440061753898,"GPR137C","G protein-coupled receptor 137C",TRUE
+"1563720_at",0.8288884913487,0.399462325267692,-0.859141647876588,-5.58642633294045,-0.585379550627075,"GPR141","G protein-coupled receptor 141",TRUE
+"206696_at",0.931941664456949,0.699147287863327,-0.39152772238969,-5.8652942067484,-0.411790528589311,"GPR143","G protein-coupled receptor 143",TRUE
+"228770_at",0.673582826047901,0.139758945189545,-1.53166763229106,-4.8573891539698,-0.778750991234753,"GPR146","G protein-coupled receptor 146",TRUE
+"208524_at",0.679041081350052,0.146600605835953,1.50440044062088,-4.89365559489662,0.838941756807721,"GPR15","G protein-coupled receptor 15",TRUE
+"231349_at",0.966111788889917,0.842286582405322,0.201318101282206,-5.91996256714262,0.170211007795372,"GPR150","G protein-coupled receptor 150",TRUE
+"64942_at",0.82943007322906,0.400673901042674,0.856899459502797,-5.58823604755978,0.289194732956645,"GPR153","G protein-coupled receptor 153",TRUE
+"221902_at",0.877333806479767,0.527054299434375,0.642637069602893,-5.74051230876087,0.500136223628306,"GPR153","G protein-coupled receptor 153",TRUE
+"231166_at",0.597654932724127,0.0740171666556801,-1.8751244728826,-4.35845166026715,-1.67796192463919,"GPR155","G protein-coupled receptor 155",TRUE
+"239533_at",0.685154158710982,0.153642358321347,-1.47740130414968,-4.92905056871412,-1.56295644895951,"GPR155","G protein-coupled receptor 155",TRUE
+"244509_at",0.986361618040699,0.935763588028723,-0.0815158730491387,-5.93644754353983,-0.0551512076870067,"GPR155","G protein-coupled receptor 155",TRUE
+"1553028_at",0.618085483489405,0.0889794392417944,1.77890877752934,-4.50575132932616,1.29142050113726,"GPR156","G protein-coupled receptor 156",TRUE
+"239607_at",0.7717895132349,0.281824922391125,1.10309124496138,-5.36378583716111,0.367335179340573,"GPR156","G protein-coupled receptor 156",TRUE
+"227970_at",0.755639383619058,0.249619256025829,-1.18230137080464,-5.28085913989101,-0.480578872122498,"GPR157","G protein-coupled receptor 157",TRUE
+"220901_at",0.871451481476429,0.512610762195024,0.665482465524726,-5.72625117003334,0.30211282606963,"GPR157","G protein-coupled receptor 157",TRUE
+"232195_at",0.789661545166663,0.317392741415454,1.02290351581951,-5.44251236787683,1.56542548819863,"GPR158","G protein-coupled receptor 158",TRUE
+"223423_at",0.977860524436236,0.892692315613824,-0.136456988013157,-5.93061818461488,-0.151926246400588,"GPR160","G protein-coupled receptor 160",TRUE
+"235961_at",0.315093142651413,0.00676728218796925,2.98667205209387,-2.33487655388394,2.83754405488122,"GPR161","G protein-coupled receptor 161",TRUE
+"206972_s_at",0.398650588126476,0.0139791529664283,2.66864921188063,-2.96280519269573,2.96252615347454,"GPR161","G protein-coupled receptor 161",TRUE
+"232350_x_at",0.531252719138635,0.041650697911488,2.16236491963814,-3.88754959690571,1.06768189974294,"GPR161","G protein-coupled receptor 161",TRUE
+"214104_at",0.536312664356659,0.0431208133975651,2.14552675139469,-3.91635286077777,2.60120229143691,"GPR161","G protein-coupled receptor 161",TRUE
+"230369_at",0.610660880283135,0.0833177037772259,1.81353853734872,-4.45337856464621,2.36037768134596,"GPR161","G protein-coupled receptor 161",TRUE
+"206971_at",0.859947009633611,0.47845611400191,-0.720987746462345,-5.68961954074482,-0.458694762498834,"GPR161","G protein-coupled receptor 161",TRUE
+"205056_s_at",0.790887605610217,0.320892164097519,1.01536453797629,-5.44963896770148,0.753311825389325,"GPR162","G protein-coupled receptor 162",TRUE
+"206190_at",0.82376894572504,0.390967507537552,0.874987004134766,-5.57351188497112,0.405299692211956,"GPR17","G protein-coupled receptor 17",TRUE
+"215225_s_at",0.986361618040699,0.935671389152055,0.081633144990504,-5.93643822764536,0.0607936649357619,"GPR17","G protein-coupled receptor 17",TRUE
+"207651_at",0.823074246722209,0.389600745635448,-0.877557176529233,-5.57139645132906,-0.442467155865532,"GPR171","G protein-coupled receptor 171",TRUE
+"244877_at",0.70939075283402,0.18235850152726,1.37669898380688,-5.05644767869763,0.745491820667388,"GPR173","G protein-coupled receptor 173",TRUE
+"221299_at",0.836073870069938,0.417331439509666,0.826501849064763,-5.61233489929157,0.457432448634089,"GPR173","G protein-coupled receptor 173",TRUE
+"1556039_s_at",0.932571848050436,0.702225584919504,0.387305242341869,-5.86688433786749,0.370270502846291,"GPR173","G protein-coupled receptor 173",TRUE
+"1556038_at",0.99008680948608,0.951189571867862,-0.0619100261335779,-5.93781681259855,-0.050978939864216,"GPR173","G protein-coupled receptor 173",TRUE
+"224285_at",0.965354569120706,0.838393014745486,0.206361550977764,-5.91896311304129,0.139581043060865,"GPR174","G protein-coupled receptor 174",TRUE
+"227846_at",0.744573608322482,0.235892166671531,1.21838616170868,-5.24141672820586,0.886937424906629,"GPR176","G protein-coupled receptor 176",TRUE
+"206673_at",0.787929163003677,0.313805683663434,1.03069198918695,-5.43509992174611,1.08532149174053,"GPR176","G protein-coupled receptor 176",TRUE
+"210279_at",0.847506138098347,0.446185244811335,0.775599836261466,-5.65086010978801,0.730881498471109,"GPR18","G protein-coupled receptor 18",TRUE
+"1556019_at",0.327864702134751,0.00764135067475426,2.93416836203902,-2.44053158408142,1.94363097455332,"GPR180","G protein-coupled receptor 180",TRUE
+"1566257_at",0.497871139123625,0.0309273182870875,2.30468081824614,-3.63865781670479,1.37152888116233,"GPR180","G protein-coupled receptor 180",TRUE
+"232912_at",0.579119470758542,0.062249951566761,1.96357712269802,-4.2182425625719,1.29381558873167,"GPR180","G protein-coupled receptor 180",TRUE
+"1566256_s_at",0.672434875127089,0.138368071500704,1.53734450146406,-4.84977353526706,1.20372924534942,"GPR180","G protein-coupled receptor 180",TRUE
+"1556021_at",0.708978267842592,0.181561291118068,1.37931721787941,-5.05322925647854,1.57136707798281,"GPR180","G protein-coupled receptor 180",TRUE
+"231871_at",0.73759219552868,0.223986714484851,1.25099098076513,-5.20489707240916,0.633247418536554,"GPR180","G protein-coupled receptor 180",TRUE
+"214506_at",0.85463333818278,0.466276709772001,0.741333436767083,-5.67549309473947,0.242310336121154,"GPR182","G protein-coupled receptor 182",TRUE
+"1552440_at",0.874474734833648,0.520697730613752,0.652648211703702,-5.73432173331576,0.365820142906592,"GPR182","G protein-coupled receptor 182",TRUE
+"205419_at",0.901926599164492,0.600207501517624,0.531725335259929,-5.80290559349319,0.284574385949544,"GPR183","G protein-coupled receptor 183",TRUE
+"207183_at",0.595935839284243,0.0723278900578139,1.8870279735587,-4.33984521530438,1.07513728378307,"GPR19","G protein-coupled receptor 19",TRUE
+"232841_at",0.899852720655724,0.593861650103712,0.541064897387728,-5.79809232726633,0.177256631291945,"GPR20","G protein-coupled receptor 20",TRUE
+"214510_at",0.95442332217412,0.79051850211399,0.26886863566826,-5.90453472777527,0.182899821220538,"GPR20","G protein-coupled receptor 20",TRUE
+"221294_at",0.908619002315341,0.61980529145593,0.503177144694927,-5.81711205425583,0.136113858219476,"GPR21","G protein-coupled receptor 21",TRUE
+"221288_at",0.855075448726859,0.467308476897348,0.739597801119656,-5.67671273849431,0.549085038411614,"GPR22","G protein-coupled receptor 22",TRUE
+"244493_at",0.860273226754149,0.479710791126189,0.718909157887366,-5.69104171500734,0.874690846857048,"GPR22","G protein-coupled receptor 22",TRUE
+"221363_x_at",0.512681169570718,0.0342912672541402,-2.25574231589615,-3.72531728640093,-1.53457592392353,"GPR25","G protein-coupled receptor 25",TRUE
+"1553864_at",0.841967750949524,0.43496523121497,0.795144336083732,-5.63634006478261,0.633137875908623,"GPR26","G protein-coupled receptor 26",TRUE
+"1553865_a_at",0.92148618812595,0.665438129986661,0.43826408863573,-5.8465611822562,0.183095244269563,"GPR26","G protein-coupled receptor 26",TRUE
+"244617_at",0.990980060324272,0.957666455369978,0.0536860099361144,-5.9382797709023,0.0295542868056966,"GPR26","G protein-coupled receptor 26",TRUE
+"227769_at",0.487765518929235,0.0289094170929308,-2.33643378242933,-3.58185221841928,-2.81485878059082,"GPR27","G protein-coupled receptor 27",TRUE
+"221306_at",0.94895689004559,0.768252301196534,-0.298301850418732,-5.89643535224431,-0.114334881845847,"GPR27","G protein-coupled receptor 27",TRUE
+"214613_at",0.994057527155985,0.972349165246077,0.0350557863810158,-5.93908494262034,0.0236904175904487,"GPR3","G protein-coupled receptor 3",TRUE
+"208556_at",0.978316880841318,0.895841301791855,0.132427685132312,-5.93114541802879,0.0503684530541428,"GPR31","G protein-coupled receptor 31",TRUE
+"221469_at",0.767011398042819,0.268527359917295,1.13494558277322,-5.33104602355072,0.720237558802174,"GPR32","G protein-coupled receptor 32",TRUE
+"223620_at",0.726636642789909,0.20585585264474,-1.30329357802465,-5.1445925267817,-0.827407554845921,"GPR34","G protein-coupled receptor 34",TRUE
+"210264_at",0.819780516863333,0.377277544299799,0.901001025463815,-5.55183517401823,0.390225177625266,"GPR35","G protein-coupled receptor 35",TRUE
+"214586_at",0.832702207166299,0.40947474242109,0.84074113730433,-5.60114734695183,0.632352019117235,"GPR37","G protein-coupled receptor 37",TRUE
+"207055_at",0.661974206478491,0.129498953118704,-1.57469431618498,-4.79911399820341,-1.10041649646778,"GPR37L1","G protein-coupled receptor 37 like 1",TRUE
+"1556155_at",0.755719147268412,0.250087548148938,-1.18109688359741,-5.28215789016557,-0.917882770461302,"GPR37L1","G protein-coupled receptor 37 like 1",TRUE
+"208600_s_at",0.64484773720849,0.115286881055658,1.63923691863797,-4.70934040577287,1.4807325125724,"GPR39","G protein-coupled receptor 39",TRUE
+"229105_at",0.723918900915296,0.200803914975425,1.31849999465482,-5.12666640546895,0.879268780604283,"GPR39","G protein-coupled receptor 39",TRUE
+"229104_s_at",0.737488397392592,0.223679780287896,1.25184884285516,-5.20392500705091,1.07534306337732,"GPR39","G protein-coupled receptor 39",TRUE
+"206236_at",0.832792886465252,0.409913715742929,0.83994100819591,-5.60178072918136,0.450670657641337,"GPR4","G protein-coupled receptor 4",TRUE
+"211266_s_at",0.920780424288498,0.663031198374542,0.441638196697951,-5.84512852096202,0.353776771619731,"GPR4","G protein-coupled receptor 4",TRUE
+"221385_s_at",0.878278790222455,0.530905264616968,0.636604125728905,-5.74419848786907,0.265972263216734,"GPR42///FFAR3","G protein-coupled receptor 42 (gene/pseudogene)///free fatty acid receptor 3",TRUE
+"211175_at",0.942303845415102,0.740514088767765,0.335351942481944,-5.88505586379984,0.210638317922095,"GPR45","G protein-coupled receptor 45",TRUE
+"208311_at",0.939976205834042,0.730122359249267,-0.349353583484647,-5.88041263932222,-0.204531795278911,"GPR50","G protein-coupled receptor 50",TRUE
+"221313_at",0.830960037055612,0.40483369926018,0.849234112648383,-5.59438961526987,0.366754199942878,"GPR52","G protein-coupled receptor 52",TRUE
+"237559_at",0.753209533292557,0.24646856618771,1.19044942708491,-5.27204309931478,1.10004875743023,"GPR55","G protein-coupled receptor 55",TRUE
+"231745_at",0.78226567430527,0.304387456854028,-1.0514445059032,-5.4151021511727,-0.827940129920641,"GPR55","G protein-coupled receptor 55",TRUE
+"214655_at",0.321614980455327,0.00715876417401249,-2.96239809513294,-2.3838125230084,-1.92152260891736,"GPR6","G protein-coupled receptor 6",TRUE
+"1553507_a_at",0.774230543658252,0.288920303387985,1.08653910688352,-5.38047117522071,0.344549186750903,"GPR6","G protein-coupled receptor 6",TRUE
+"224531_at",0.753624601581595,0.246887444631415,1.18936168304002,-5.27322307003519,0.681975464969583,"GPR61","G protein-coupled receptor 61",TRUE
+"1554559_at",0.905462783815257,0.611393812248239,0.515376949277093,-5.81113452124312,0.341962980647827,"GPR62","G protein-coupled receptor 62",TRUE
+"220993_s_at",0.94895689004559,0.768071006066798,0.298542572069554,-5.89636567340754,0.195122231420418,"GPR63","G protein-coupled receptor 63",TRUE
+"214467_at",0.727074488271062,0.207257063206706,-1.29912734401123,-5.14947317043891,-0.928091445674658,"GPR65","G protein-coupled receptor 65",TRUE
+"229055_at",0.872238421308015,0.51523885309529,-0.661299377965106,-5.7288981728583,-0.44998539923201,"GPR68","G protein-coupled receptor 68",TRUE
+"211249_at",0.946416600885596,0.75779251660114,0.312220212534278,-5.89231506965838,0.294164737649274,"GPR68","G protein-coupled receptor 68",TRUE
+"220481_at",0.661974206478491,0.129327214516784,1.57543818702552,-4.79809533992109,1.0631969629117,"GPR75","G protein-coupled receptor 75",TRUE
+"224524_s_at",0.767011398042819,0.268675333197699,1.1345848348437,-5.33142141115309,0.348364328812767,"GPR75-ASB3///ASB3","GPR75-ASB3 readthrough///ankyrin repeat and SOCS box containing 3",TRUE
+"232515_at",0.876590919968167,0.525296689838734,0.645398533840545,-5.73881388512986,0.249715192469649,"GPR75-ASB3///ASB3///GPR75","GPR75-ASB3 readthrough///ankyrin repeat and SOCS box containing 3///G protein-coupled receptor 75",TRUE
+"1553063_at",0.79782885150643,0.331619113658966,0.992606061905745,-5.47086270418233,0.734247600725713,"GPR78","G protein-coupled receptor 78",TRUE
+"211062_s_at",0.000171298494330477,1.51797605757857e-08,8.63963981683737,8.74636795038516,4.50285020321907,"GPR78///CPZ","G protein-coupled receptor 78///carboxypeptidase Z",TRUE
+"1553316_at",0.735413789306046,0.220381868175639,1.26112360422987,-5.19337905865844,0.75978557103394,"GPR82","G protein-coupled receptor 82",TRUE
+"244434_at",0.759211729028446,0.256833655969093,1.16392899041653,-5.30054347622997,0.979665299774986,"GPR82","G protein-coupled receptor 82",TRUE
+"1553317_s_at",0.83030603167465,0.402412465654318,-0.853689597339151,-5.59081912351256,-0.777429719826926,"GPR82","G protein-coupled receptor 82",TRUE
+"222953_at",0.989638901366417,0.949904159702893,-0.0635426789223371,-5.93771707090177,-0.0543854006336559,"GPR83","G protein-coupled receptor 83",TRUE
+"223767_at",0.692289844352812,0.161766930751289,1.44747188530393,-4.96768093773757,1.03643308889699,"GPR84","G protein-coupled receptor 84",TRUE
+"234303_s_at",0.64513208805899,0.115922528699218,1.63621164415615,-4.71361050188115,1.67459779580246,"GPR85","G protein-coupled receptor 85",TRUE
+"219898_at",0.812302873476553,0.358434689464022,0.937846643766113,-5.52013038422101,0.722325922504393,"GPR85","G protein-coupled receptor 85",TRUE
+"219936_s_at",0.0984173594430505,0.000431345275531866,4.1324042437251,0.0851385665210946,5.34419103485051,"GPR87","G protein-coupled receptor 87",TRUE
+"220313_at",0.681732274610686,0.149357337499998,1.49370736432556,-4.9077354820268,0.901733756594278,"GPR88","G protein-coupled receptor 88",TRUE
+"222140_s_at",0.796963640275795,0.329824603482299,-0.996377383751375,-5.46737588442747,-0.354089265413698,"GPR89A///GPR89B","G protein-coupled receptor 89A///G protein-coupled receptor 89B",TRUE
+"225463_x_at",0.860330607164155,0.479802485114758,-0.718757375437516,-5.69114541183946,-0.231181012390431,"GPR89A///GPR89B","G protein-coupled receptor 89A///G protein-coupled receptor 89B",TRUE
+"220642_x_at",0.885029460971826,0.54597978147528,-0.613212460667937,-5.75817447535859,-0.189613672513071,"GPR89A///GPR89B","G protein-coupled receptor 89A///G protein-coupled receptor 89B",TRUE
+"223531_x_at",0.936992192746977,0.718722783383639,-0.364795615553916,-5.8750741833176,-0.106259826134499,"GPR89A///GPR89B","G protein-coupled receptor 89A///G protein-coupled receptor 89B",TRUE
+"1562412_at",0.894148639994082,0.57043984840665,0.575970439824806,-5.77938320291028,0.462805360815225,"GPR89B","G protein-coupled receptor 89B",TRUE
+"204793_at",0.906507435035949,0.614441306110292,0.510947877941759,-5.81332077684359,0.182440566894991,"GPRASP1","G protein-coupled receptor associated sorting protein 1",TRUE
+"235563_at",0.29255198477894,0.00515824464522671,3.10311305957117,-2.09813415759541,3.4200756387484,"GPRC5A","G protein-coupled receptor class C group 5 member A",TRUE
+"212444_at",0.335661229817476,0.00828689483021046,2.89896296631089,-2.5109686077565,2.59214517597437,"GPRC5A","G protein-coupled receptor class C group 5 member A",TRUE
+"203108_at",0.364513221153898,0.0106642018786465,2.78863349537979,-2.72944520188691,2.59168942772918,"GPRC5A","G protein-coupled receptor class C group 5 member A",TRUE
+"225511_at",0.619415519928971,0.0895697901878344,1.77540820518131,-4.51100451070199,1.6037585872542,"GPRC5B","G protein-coupled receptor class C group 5 member B",TRUE
+"203632_s_at",0.627092759817312,0.0979848025596234,1.7275480823957,-4.58206100358496,2.03880847796288,"GPRC5B","G protein-coupled receptor class C group 5 member B",TRUE
+"203631_s_at",0.855075448726859,0.467375486127798,0.739485156989285,-5.67679180064721,0.43020503459528,"GPRC5B","G protein-coupled receptor class C group 5 member B",TRUE
+"228313_at",0.885312914741353,0.546567625630812,0.612307312087329,-5.7587051492636,0.332608429894922,"GPRC5B","G protein-coupled receptor class C group 5 member B",TRUE
+"219327_s_at",0.324623663332327,0.00742041454843123,-2.9468739495431,-2.41502942786049,-3.22366337932362,"GPRC5C","G protein-coupled receptor class C group 5 member C",TRUE
+"230907_at",0.346977602268172,0.00896577423367705,-2.86466039747879,-2.57927125681429,-1.67252598814195,"GPRC5C","G protein-coupled receptor class C group 5 member C",TRUE
+"221297_at",0.759775603960987,0.257594154012342,1.16201473285494,-5.30257889949301,0.52632641364954,"GPRC5D","G protein-coupled receptor class C group 5 member D",TRUE
+"1552775_at",0.955396260969248,0.795622093885983,-0.262157299623949,-5.90626468854026,-0.1800694609797,"GPRC6A","G protein-coupled receptor class C group 6 member A",TRUE
+"229922_at",0.612420348961838,0.0842133541330909,1.80792757138508,-4.46191405805793,1.33326495880781,"GPRIN1","G protein regulated inducer of neurite outgrowth 1",TRUE
+"227975_at",0.901978467243536,0.600345649775208,-0.531522548702819,-5.80300919786475,-0.177887832800306,"GPRIN1","G protein regulated inducer of neurite outgrowth 1",TRUE
+"1554541_a_at",0.0277242942311338,2.60842729592759e-05,5.28226923325506,2.5469060533166,3.06405204402215,"GPRIN2","G protein regulated inducer of neurite outgrowth 2",TRUE
+"206747_at",0.142607803108174,0.000969794316168205,3.80072869497305,-0.629529158726413,1.2879439808371,"GPRIN2","G protein regulated inducer of neurite outgrowth 2",TRUE
+"232687_at",0.631316839203356,0.102633395114467,-1.70259767181846,-4.61853108662711,-1.86508114507091,"GPRIN3","GPRIN family member 3",TRUE
+"238378_at",0.768852835478002,0.273897583029306,1.12194558845404,-5.34450701576868,0.938727589058478,"GPRIN3","GPRIN family member 3",TRUE
+"1556697_at",0.812302873476553,0.358940754868968,-0.936840378872287,-5.52101177588955,-1.06684466929538,"GPRIN3","GPRIN family member 3",TRUE
+"240173_at",0.895690630367785,0.575490373375047,0.568383759508473,-5.78354605828821,0.312066164263519,"GPRIN3","GPRIN family member 3",TRUE
+"1556698_a_at",0.913300726876965,0.636502632356876,-0.479184901373221,-5.82845955579611,-0.360900799282192,"GPRIN3","GPRIN family member 3",TRUE
+"217782_s_at",0.535243600695458,0.0426607879530641,-2.15073922395642,-3.90745150388913,-0.88485467652265,"GPS1","G protein pathway suppressor 1",TRUE
+"209350_s_at",0.47652109797903,0.0263776074952388,2.37929133472669,-3.50447984562281,0.655445330739264,"GPS2","G protein pathway suppressor 2",TRUE
+"226043_at",0.754579670006269,0.248076260966853,-1.18628206806641,-5.2765586978443,-0.671001479093562,"GPSM1","G-protein signaling modulator 1",TRUE
+"1554259_at",0.76029267756668,0.258881916383336,1.15878282407075,-5.30600870791323,0.686193793783537,"GPSM1","G-protein signaling modulator 1",TRUE
+"230002_at",0.813021058415276,0.362070524670122,0.930638178873795,-5.52642511428273,0.437274374734947,"GPSM2","G-protein signaling modulator 2",TRUE
+"221922_at",0.843475287501313,0.438703144331226,0.788599158632033,-5.64124052425621,0.306598518242552,"GPSM2","G-protein signaling modulator 2",TRUE
+"205240_at",0.930899509890345,0.694076257260086,0.398499497039332,-5.86263155153704,0.160305084730838,"GPSM2","G-protein signaling modulator 2",TRUE
+"233058_at",0.940756067985891,0.734853512438605,0.342970248784925,-5.88255276849057,0.151363403886895,"GPSM2","G-protein signaling modulator 2",TRUE
+"204265_s_at",0.820288124919738,0.378577765844698,0.898503985103274,-5.55394138611829,0.47012539099792,"GPSM3","G-protein signaling modulator 3",TRUE
+"214847_s_at",0.980009054680439,0.905695319997876,0.119833096074435,-5.93269168779084,0.0712185422927201,"GPSM3","G-protein signaling modulator 3",TRUE
+"206709_x_at",0.87579870142401,0.523745344681196,-0.647840127420764,-5.7373063698228,-0.233957235910448,"GPT","glutamic--pyruvic transaminase",TRUE
+"224839_s_at",0.713673813939397,0.188890237979278,-1.35558138185698,-5.08221992140951,-0.491767448715935,"GPT2","glutamic--pyruvic transaminase 2",TRUE
+"200736_s_at",0.720021194788968,0.196058669276504,1.33305743977441,-5.10934105254902,3.24164358361128,"GPX1","glutathione peroxidase 1",TRUE
+"202831_at",0.76720608863012,0.269184397563834,1.13334488600313,-5.33271087588748,1.25512964979811,"GPX2","glutathione peroxidase 2",TRUE
+"239595_at",0.897949253801113,0.586416828386941,0.552084363144477,-5.79230856462802,0.302938283099729,"GPX2","glutathione peroxidase 2",TRUE
+"214091_s_at",0.552420073963858,0.0502471640911745,2.07058793742862,-4.04280358207448,2.21960519838232,"GPX3","glutathione peroxidase 3",TRUE
+"201348_at",0.592111379991983,0.0692320867960927,1.90948871749607,-4.30451236085072,2.88097215231905,"GPX3","glutathione peroxidase 3",TRUE
+"201106_at",0.878218253751206,0.53022722359884,-0.637664618993909,-5.74355293895943,-0.190519446730534,"GPX4","glutathione peroxidase 4",TRUE
+"208028_s_at",0.746610433933075,0.238492020642728,1.2114327570313,-5.24909718610407,0.970487544250204,"GPX5","glutathione peroxidase 5",TRUE
+"214648_at",0.893914276642775,0.56997731752719,-0.576666936404618,-5.77899835170405,-0.537202798090959,"GPX5","glutathione peroxidase 5",TRUE
+"213170_at",0.463552233135475,0.0236776027041564,2.4294003837511,-3.41302501368042,2.46403799637102,"GPX7","glutathione peroxidase 7",TRUE
+"227628_at",0.643082025527735,0.1135534517922,1.64755876856272,-4.6975631398841,1.6022306953621,"GPX8","glutathione peroxidase 8 (putative)",TRUE
+"228141_at",0.654623800601032,0.123601300080323,1.600722556922,-4.76324759071654,1.99549280696513,"GPX8","glutathione peroxidase 8 (putative)",TRUE
+"224807_at",0.471442074753508,0.0256436896262814,-2.3924248701725,-3.480611534646,-0.756349665684462,"GRAMD1A","GRAM domain containing 1A",TRUE
+"244808_at",0.990623482682449,0.952701672910993,0.0599896672153864,-5.93793080935649,0.0231443583297981,"GRAMD1A","GRAM domain containing 1A",TRUE
+"212906_at",0.116353869957079,0.000625661413212277,3.98041155922224,-0.242930262041704,1.96468327756812,"GRAMD1B","GRAM domain containing 1B",TRUE
+"219313_at",0.895457620469779,0.574544242429568,0.569802420533515,-5.78277169639965,0.51744697961242,"GRAMD1C","GRAM domain containing 1C",TRUE
+"230828_at",0.622917527985155,0.0938115928400634,1.75082300452898,-4.54768446182755,0.951096193733076,"GRAMD2","GRAM domain containing 2",TRUE
+"229616_s_at",0.71454754703986,0.189714959855069,1.35295615805001,-5.08540054624576,1.57932818322339,"GRAMD2","GRAM domain containing 2",TRUE
+"218706_s_at",0.643688366500038,0.11431980847894,1.64386655961708,-4.70279407503152,0.838475418296314,"GRAMD3","GRAM domain containing 3",TRUE
+"238049_at",0.751112081216662,0.244112404439462,1.19659385756797,-5.26536006630238,0.74688012225475,"GRAMD3","GRAM domain containing 3",TRUE
+"1569154_a_at",0.641209837140528,0.111682510820105,-1.6566616343212,-4.68462833966485,-1.48665614188128,"GRAMD4","GRAM domain containing 4",TRUE
+"212856_at",0.689377560557554,0.158433028216773,-1.45960277546142,-4.95210070269248,-0.665684386534647,"GRAMD4","GRAM domain containing 4",TRUE
+"1569153_at",0.990810941805126,0.955533422187692,-0.0563939791886059,-5.93813460189229,-0.0264238372428567,"GRAMD4","GRAM domain containing 4",TRUE
+"229726_at",0.726696341943087,0.2066216355742,-1.30101395075306,-5.14726469683932,-0.584736764537597,"GRAP","GRB2-related adaptor protein",TRUE
+"206620_at",0.83738581710561,0.42135018224769,0.819283704029817,-5.61793774924626,0.760885840256893,"GRAP","GRB2-related adaptor protein",TRUE
+"208406_s_at",0.832605695407954,0.409157820716083,0.841319138495447,-5.60068945083502,0.304316475380318,"GRAP2","GRB2-related adaptor protein 2",TRUE
+"1559689_a_at",0.702630084418366,0.174094881547934,1.40429294918192,-5.02227383096577,0.965108227570822,"GRAPL","GRB2 related adaptor protein like",TRUE
+"1559688_at",0.90214409832534,0.600571392608061,0.531191231406332,-5.80317838630403,0.524299119992312,"GRAPL","GRB2 related adaptor protein like",TRUE
+"239074_at",0.949216032237554,0.770693106568262,-0.295062721092461,-5.89736752421129,-0.0880426638277196,"GRAPL","GRB2 related adaptor protein like",TRUE
+"1560524_at",0.99663793883595,0.983305580056504,0.0211623416869154,-5.93946535445894,0.00773989647298645,"GRAPL","GRB2 related adaptor protein like",TRUE
+"228263_at",0.678772326285111,0.146354059117303,-1.50536475002282,-4.89238190378472,-1.06028464493261,"GRASP","general receptor for phosphoinositides 1 associated scaffold protein",TRUE
+"1570186_at",0.965255754814725,0.838172598537821,0.206647224972979,-5.91890576436485,0.132352228594783,"GRASPOS","GRP1-associated scaffold protein opposite strand",TRUE
+"209410_s_at",0.663325052838397,0.131338055153654,-1.56677927179183,-4.80992950365198,-0.872581772834302,"GRB10","growth factor receptor bound protein 10",TRUE
+"215248_at",0.758920166935337,0.256131528096899,-1.16570006093611,-5.29865768821775,-0.863415371884936,"GRB10","growth factor receptor bound protein 10",TRUE
+"209409_at",0.783803492578037,0.306367890990128,-1.04704342280554,-5.41937313244303,-1.09129185502244,"GRB10","growth factor receptor bound protein 10",TRUE
+"210999_s_at",0.873665367559788,0.519209907881941,-0.655001108261351,-5.73285344575454,-0.624914178716649,"GRB10","growth factor receptor bound protein 10",TRUE
+"206204_at",0.85551315710265,0.468760185834132,0.737159581064198,-5.67842151284193,1.09580120706642,"GRB14","growth factor receptor bound protein 14",TRUE
+"228572_at",0.608709711882903,0.0813414706137839,-1.82610612870145,-4.43419141100273,-1.28249336254975,"GRB2","growth factor receptor bound protein 2",TRUE
+"223049_at",0.704665987011002,0.176560422434813,-1.39595282110332,-5.03266183915107,-0.63354632973161,"GRB2","growth factor receptor bound protein 2",TRUE
+"215075_s_at",0.90427866743639,0.606853118515896,-0.521995616695281,-5.80783317830808,-0.271056330923951,"GRB2","growth factor receptor bound protein 2",TRUE
+"210761_s_at",0.893600768892136,0.56868655848868,-0.578612136415169,-5.77792114051081,-0.669949498209803,"GRB7","growth factor receptor bound protein 7",TRUE
+"205862_at",0.575465599641614,0.0609409386726099,-1.97430930671228,-4.20092933962988,-5.03543132533216,"GREB1","growth regulation by estrogen in breast cancer 1",TRUE
+"210855_at",0.900171779891306,0.594870690141138,-0.539576596250338,-5.79886480156599,-0.46044615695239,"GREB1","growth regulation by estrogen in breast cancer 1",TRUE
+"210562_at",0.934352397958111,0.709157303948144,0.377823095823233,-5.87039324292755,0.269725667318357,"GREB1","growth regulation by estrogen in breast cancer 1",TRUE
+"243907_at",0.304824368772306,0.0060173014538259,3.03719540398883,-2.23255041090534,1.36901953478463,"GREB1L","growth regulation by estrogen in breast cancer 1 like",TRUE
+"233977_at",0.51531387545335,0.0359064255340707,2.23378609105531,-3.76383752015671,0.705683347538884,"GREB1L","growth regulation by estrogen in breast cancer 1 like",TRUE
+"220340_at",0.51531387545335,0.0359349659569221,2.23340627431513,-3.76450188380465,1.13595869007744,"GREB1L","growth regulation by estrogen in breast cancer 1 like",TRUE
+"218468_s_at",0.0823353801878483,0.000300804908326115,4.2794894941473,0.402968581949458,4.68973494990764,"GREM1","gremlin 1, DAN family BMP antagonist",TRUE
+"218469_at",0.308621629697291,0.00627264457184687,3.01934617606498,-2.26877223883534,2.99966591267777,"GREM1","gremlin 1, DAN family BMP antagonist",TRUE
+"220794_at",0.782672765138354,0.305038389617434,-1.04999571565068,-5.41650989057113,-0.840341294930776,"GREM2","gremlin 2, DAN family BMP antagonist",TRUE
+"240509_s_at",0.95279845708016,0.783950955431145,-0.277523754041961,-5.90223962224093,-0.278884259985451,"GREM2","gremlin 2, DAN family BMP antagonist",TRUE
+"235504_at",0.993083193605528,0.967145667732796,0.0416564645319337,-5.93883833441871,0.0196742380967665,"GREM2","gremlin 2, DAN family BMP antagonist",TRUE
+"1552685_a_at",0.761261833217751,0.260325408370215,-1.15517419957112,-5.30982839223941,-0.736785276824742,"GRHL1","grainyhead like transcription factor 1",TRUE
+"222830_at",0.834881450121645,0.413526228262009,-0.833376938125756,-5.60695557249371,-0.882443331778127,"GRHL1","grainyhead like transcription factor 1",TRUE
+"219388_at",0.893175412268596,0.567662808770627,0.5801565521161,-5.77706337419507,0.587369996505968,"GRHL2","grainyhead like transcription factor 2",TRUE
+"232116_at",0.756584150514497,0.251901296937864,1.17644758865427,-5.28716019347633,1.1900995296887,"GRHL3","grainyhead like transcription factor 3",TRUE
+"214864_s_at",0.495360599872936,0.0301882307960973,-2.31608390514198,-3.61830947589241,-0.630567460194442,"GRHPR","glyoxylate and hydroxypyruvate reductase",TRUE
+"216308_x_at",0.61591966964196,0.0869946340906581,-1.79082650909275,-4.48781022218762,-0.542157113491253,"GRHPR","glyoxylate and hydroxypyruvate reductase",TRUE
+"201347_x_at",0.64484773720849,0.115276699119906,-1.63928549203188,-4.7092717963096,-0.465016273185034,"GRHPR","glyoxylate and hydroxypyruvate reductase",TRUE
+"209793_at",0.792305111661886,0.323379880261958,1.01003998504543,-5.4546435261323,0.420771832288089,"GRIA1","glutamate ionotropic receptor AMPA type subunit 1",TRUE
+"211520_s_at",0.954723352940649,0.79401463585009,-0.264269800752352,-5.90572483953075,-0.188173778819951,"GRIA1","glutamate ionotropic receptor AMPA type subunit 1",TRUE
+"241172_at",0.727286289873957,0.207578171958074,1.2981756666206,-5.15058617852279,1.13287907916605,"GRIA2","glutamate ionotropic receptor AMPA type subunit 2",TRUE
+"236538_at",0.795828967958589,0.328069302401804,1.00008006946513,-5.4639408424137,1.02890215985209,"GRIA2","glutamate ionotropic receptor AMPA type subunit 2",TRUE
+"205358_at",0.992784989582189,0.965804829435583,0.0433576239522351,-5.93876790025909,0.020601276637684,"GRIA2","glutamate ionotropic receptor AMPA type subunit 2",TRUE
+"230144_at",0.491581666454407,0.0294651696063506,2.32749044907803,-3.5978969702022,1.96851658199614,"GRIA3","glutamate ionotropic receptor AMPA type subunit 3",TRUE
+"206730_at",0.663819586595936,0.131868175157421,-1.56451482410634,-4.8130158820928,-0.960317509619099,"GRIA3","glutamate ionotropic receptor AMPA type subunit 3",TRUE
+"208032_s_at",0.812302873476553,0.359174235187752,0.936376445905197,-5.5214178440483,0.687221803792374,"GRIA3","glutamate ionotropic receptor AMPA type subunit 3",TRUE
+"217565_at",0.8920930097751,0.562744851051141,0.587595710565364,-5.77290068046494,0.424018697561588,"GRIA3","glutamate ionotropic receptor AMPA type subunit 3",TRUE
+"1569290_s_at",0.9802233499944,0.907292350266699,-0.117793827372252,-5.93292755084813,-0.082145303123959,"GRIA3","glutamate ionotropic receptor AMPA type subunit 3",TRUE
+"1569178_at",0.862154122939063,0.48504546541574,0.71010649513493,-5.69702119538147,0.701496668698384,"GRIA4","glutamate ionotropic receptor AMPA type subunit 4",TRUE
+"208464_at",0.917102138198416,0.649604453677183,-0.460557496501616,-5.8368957135524,-0.222990354854874,"GRIA4","glutamate ionotropic receptor AMPA type subunit 4",TRUE
+"238663_x_at",0.919354071504066,0.65675515756788,0.450460813725471,-5.84133145561555,0.248215579592206,"GRIA4","glutamate ionotropic receptor AMPA type subunit 4",TRUE
+"1555267_at",0.748184017928985,0.240691516988622,1.20559463788351,-5.25551631008281,0.392649307306912,"GRID1","glutamate ionotropic receptor delta type subunit 1",TRUE
+"231977_at",0.957932921420272,0.81070822386756,0.24238915785445,-5.91110774843157,0.151083271067972,"GRID1","glutamate ionotropic receptor delta type subunit 1",TRUE
+"1555268_a_at",0.96112720376652,0.822535034136978,0.226961024017885,-5.91462531999304,0.157426733735553,"GRID1","glutamate ionotropic receptor delta type subunit 1",TRUE
+"1557874_at",0.864079461576774,0.490964693543391,0.700404601814344,-5.70353019929992,0.557660247497922,"GRID1-AS1","GRID1 antisense RNA 1",TRUE
+"221364_at",0.939610295972262,0.729174754197795,-0.350633876678166,-5.87997870157138,-0.261830500435665,"GRID2","glutamate ionotropic receptor delta type subunit 2",TRUE
+"214611_at",0.868397087637799,0.504332734573213,-0.678737332967325,-5.71775812169017,-0.382370744994686,"GRIK1","glutamate ionotropic receptor kainate type subunit 1",TRUE
+"207242_s_at",0.895213601869362,0.573345529290088,-0.57160151029522,-5.78178699093007,-0.4384519896374,"GRIK1","glutamate ionotropic receptor kainate type subunit 1",TRUE
+"1559923_at",0.991957147109766,0.962917945502755,0.0470207469988575,-5.93860666557986,0.0299575322330341,"GRIK1","glutamate ionotropic receptor kainate type subunit 1",TRUE
+"1554203_at",0.863918945062466,0.490057578578004,0.701887017082934,-5.70254117101874,0.26805752714377,"GRIK1-AS1","GRIK1 antisense RNA 1",TRUE
+"1560378_at",0.703902004301726,0.17562182162248,1.39911679311493,-5.02872698244519,0.947570434176034,"GRIK1-AS2","GRIK1 antisense RNA 2",TRUE
+"210818_s_at",0.759156678237018,0.256772761662104,1.1640824498313,-5.3003801762266,0.453061496701475,"GRIK1-AS2///BACH1","GRIK1 antisense RNA 2///BTB domain and CNC homolog 1",TRUE
+"1552401_a_at",0.89961817630669,0.590678588885451,-0.54576794182655,-5.79563770902431,-0.626100188084128,"GRIK1-AS2///BACH1","GRIK1 antisense RNA 2///BTB domain and CNC homolog 1",TRUE
+"1553607_at",0.808266620412549,0.351061322747618,0.952617729298444,-5.50709247075591,1.14178498534451,"GRIK1-AS2///LINC00189///BACH1","GRIK1 antisense RNA 2///long intergenic non-protein coding RNA 189///BTB domain and CNC homolog 1",TRUE
+"215655_at",0.40221114169538,0.0145817541646819,-2.64977843206364,-2.99907505841946,-1.84796955895047,"GRIK2","glutamate ionotropic receptor kainate type subunit 2",TRUE
+"1560265_at",0.541849190341655,0.0452731556939071,2.12178627326876,-3.95672218980703,1.83058067564168,"GRIK2","glutamate ionotropic receptor kainate type subunit 2",TRUE
+"1563754_at",0.565043084457947,0.056253712658032,2.01449234862509,-4.13554197416335,0.96378717528967,"GRIK2","glutamate ionotropic receptor kainate type subunit 2",TRUE
+"213845_at",0.738726167317415,0.225446087026482,1.24692436590327,-5.20949727018874,0.850826435538295,"GRIK2","glutamate ionotropic receptor kainate type subunit 2",TRUE
+"1555375_at",0.822173415758858,0.386438609195075,-0.883526087122754,-5.56646140811069,-0.878964402472318,"GRIK2","glutamate ionotropic receptor kainate type subunit 2",TRUE
+"1560142_at",0.919254462391029,0.656045891586611,0.4514601471993,-5.84089671975761,0.395378440593561,"GRIK2","glutamate ionotropic receptor kainate type subunit 2",TRUE
+"230593_at",0.80861715520522,0.351701896481169,-0.951326199975093,-5.50823990765876,-1.19444139694959,"GRIK3","glutamate ionotropic receptor kainate type subunit 3",TRUE
+"207454_at",0.819780516863333,0.377361982342045,0.900838692559536,-5.55197226335831,0.401829673125174,"GRIK3","glutamate ionotropic receptor kainate type subunit 3",TRUE
+"208552_at",0.79510118595964,0.327245761090988,-1.00182200659738,-5.46232081933065,-0.889343318979532,"GRIK4","glutamate ionotropic receptor kainate type subunit 4",TRUE
+"1553168_at",0.411017145660168,0.0159896382042831,2.60840243366747,-3.07816737054734,1.6816534994409,"GRIK5","glutamate ionotropic receptor kainate type subunit 5",TRUE
+"214966_at",0.804537788156734,0.343457648544432,0.968071996810452,-5.49325195649158,0.69303983366058,"GRIK5","glutamate ionotropic receptor kainate type subunit 5",TRUE
+"217509_x_at",0.910159094731364,0.62611462951651,-0.494076860753561,-5.82147991092414,-0.247778138867043,"GRIK5","glutamate ionotropic receptor kainate type subunit 5",TRUE
+"210782_x_at",0.768852835478002,0.272680920508013,1.124874375735,-5.34148633095109,0.555312433398186,"GRIN1","glutamate ionotropic receptor NMDA type subunit 1",TRUE
+"211125_x_at",0.81836001261482,0.371561970248768,0.912045505118901,-5.54245459421191,0.477215676269546,"GRIN1","glutamate ionotropic receptor NMDA type subunit 1",TRUE
+"205914_s_at",0.865134455950057,0.494238220971194,-0.695068001078768,-5.70707412164388,-0.310229503048175,"GRIN1","glutamate ionotropic receptor NMDA type subunit 1",TRUE
+"210781_x_at",0.949108933724268,0.770414331735103,-0.295432512279064,-5.89726161423886,-0.127192922042404,"GRIN1","glutamate ionotropic receptor NMDA type subunit 1",TRUE
+"205915_x_at",0.989524702314661,0.948899273511808,0.0648191476316797,-5.93763728152166,0.0353828234989102,"GRIN1","glutamate ionotropic receptor NMDA type subunit 1",TRUE
+"231384_at",0.544819033181092,0.0467941505225132,-2.10561519246776,-3.9840567972166,-1.91875846383711,"GRIN2A","glutamate ionotropic receptor NMDA type subunit 2A",TRUE
+"242286_at",0.817857130700434,0.370656687765418,0.913805120086338,-5.54095033260745,0.606857943416438,"GRIN2A","glutamate ionotropic receptor NMDA type subunit 2A",TRUE
+"206534_at",0.822010986888098,0.385778352285766,0.884776414917823,-5.56542371835553,0.518228882446651,"GRIN2A","glutamate ionotropic receptor NMDA type subunit 2A",TRUE
+"239095_at",0.663129351367592,0.131054764968478,1.56799247292223,-4.80827450198499,1.39749346404017,"GRIN2B","glutamate ionotropic receptor NMDA type subunit 2B",TRUE
+"210412_at",0.909441642299191,0.624072438819413,0.497017753898514,-5.8200768846265,0.189316631721973,"GRIN2B","glutamate ionotropic receptor NMDA type subunit 2B",TRUE
+"210411_s_at",0.974982245454858,0.878182047194807,0.155054698176651,-5.9279803085554,0.0749917613973472,"GRIN2B","glutamate ionotropic receptor NMDA type subunit 2B",TRUE
+"1569268_at",0.758722841981575,0.255956436230737,1.16614227972813,-5.29818643364549,0.335438994275912,"GRIN2C","glutamate ionotropic receptor NMDA type subunit 2C",TRUE
+"210400_at",0.837368340567858,0.420639993196091,-0.820556132894831,-5.61695341017604,-0.350020982014964,"GRIN2C","glutamate ionotropic receptor NMDA type subunit 2C",TRUE
+"217573_at",0.92777930247318,0.683245622744268,-0.413457809879416,-5.85676258225054,-0.112905346356311,"GRIN2C","glutamate ionotropic receptor NMDA type subunit 2C",TRUE
+"229883_at",0.0796131074879114,0.000268221918878588,4.32625241508724,0.50401210433937,2.07870540755488,"GRIN2D","glutamate ionotropic receptor NMDA type subunit 2D",TRUE
+"207036_x_at",0.605913415325856,0.0793826715025296,1.83882688545962,-4.41467361116621,1.46856592881102,"GRIN2D","glutamate ionotropic receptor NMDA type subunit 2D",TRUE
+"233220_at",0.643515428391208,0.114072839806388,1.64505414332349,-4.70111254683535,1.38743916053443,"GRIN3A","glutamate ionotropic receptor NMDA type subunit 3A",TRUE
+"233171_at",0.860085676417428,0.478716958779775,0.720555350492425,-5.6899157085734,0.422803546312687,"GRIN3A","glutamate ionotropic receptor NMDA type subunit 3A",TRUE
+"233892_at",0.969882914559333,0.856468528610811,0.182991870230418,-5.92338682148038,0.121649639046052,"GRIN3B","glutamate ionotropic receptor NMDA type subunit 3B",TRUE
+"212090_at",0.804537788156734,0.34328330381448,-0.968429067856694,-5.49292976576142,-0.463815536047367,"GRINA","glutamate ionotropic receptor NMDA type subunit associated protein 1",TRUE
+"235957_at",0.588653540532996,0.0672528843163167,-1.92431449509016,-4.28103082668792,-1.82505254084109,"GRIP1","glutamate receptor interacting protein 1",TRUE
+"214018_at",0.839466826665106,0.425919542176748,-0.81112882974853,-5.62421227820131,-0.494715272767866,"GRIP1","glutamate receptor interacting protein 1",TRUE
+"216481_at",0.944503488452294,0.750731873825441,-0.321651027009339,-5.889417480084,-0.197008762499968,"GRIP2","glutamate receptor interacting protein 2",TRUE
+"225451_at",0.726696341943087,0.206755789259223,-1.30061526939127,-5.14773162216465,-0.438164102702496,"GRIPAP1","GRIP1 associated protein 1",TRUE
+"208041_at",0.818361007577749,0.371618968379339,0.911934811939932,-5.54254913430088,0.51649422536118,"GRK1","G protein-coupled receptor kinase 1",TRUE
+"201401_s_at",0.791707425459848,0.322459977595446,1.01200554801025,-5.4527988631319,0.459322764856962,"GRK2","G protein-coupled receptor kinase 2",TRUE
+"201402_at",0.942684843065067,0.742958197521576,-0.332068802484634,-5.88611743391768,-0.152885994153228,"GRK2","G protein-coupled receptor kinase 2",TRUE
+"38447_at",0.964127563561655,0.835259813502056,0.210424049684019,-5.91814014514027,0.0506746145474803,"GRK2","G protein-coupled receptor kinase 2",TRUE
+"228771_at",0.881512841236227,0.538370298543772,-0.624976471206782,-5.75120871693051,-0.574880765558287,"GRK3","G protein-coupled receptor kinase 3",TRUE
+"204183_s_at",0.989768753740502,0.950702983816917,-0.062528040317467,-5.93777936224492,-0.0473261544742769,"GRK3","G protein-coupled receptor kinase 3",TRUE
+"204184_s_at",0.997430008678198,0.986958589839948,-0.0165311755335247,-5.93955037712808,-0.00726652268890504,"GRK3","G protein-coupled receptor kinase 3",TRUE
+"241989_at",0.622917527985155,0.0934824586169674,-1.75269612994443,-4.54490310193206,-1.58326491487172,"GRK4","G protein-coupled receptor kinase 4",TRUE
+"1560543_at",0.772430642757484,0.282934951669029,-1.10048202833656,-5.36643094875091,-1.39907763677462,"GRK4","G protein-coupled receptor kinase 4",TRUE
+"208365_s_at",0.845738161733126,0.443728301920008,-0.779853711635956,-5.64772880472763,-0.571698950671128,"GRK4","G protein-coupled receptor kinase 4",TRUE
+"210600_s_at",0.876013421649549,0.52458263261505,0.646521865847446,-5.73812098424908,0.644670889233869,"GRK4","G protein-coupled receptor kinase 4",TRUE
+"204396_s_at",0.466300647363886,0.0243253340055968,2.41691466092586,-3.43591090531089,1.78873541848409,"GRK5","G protein-coupled receptor kinase 5",TRUE
+"204395_s_at",0.56861088242915,0.0584944551793544,1.99492642825512,-4.16749087564618,1.67325661902723,"GRK5","G protein-coupled receptor kinase 5",TRUE
+"1569949_at",0.768852835478002,0.273735177194926,-1.12233598627933,-5.34410477070956,-0.7205018181653,"GRK5","G protein-coupled receptor kinase 5",TRUE
+"1557729_at",0.971216837324271,0.862962191418966,0.174622355902011,-5.92484238489521,0.0500622408220934,"GRK5","G protein-coupled receptor kinase 5",TRUE
+"210981_s_at",0.822850703882235,0.388486977065392,-0.879655936913627,-5.56966475221075,-0.290957080644093,"GRK6","G protein-coupled receptor kinase 6",TRUE
+"202849_x_at",0.922168942129244,0.667707710647949,0.435087252658349,-5.84790022211383,0.276512875421039,"GRK6","G protein-coupled receptor kinase 6",TRUE
+"202848_s_at",0.984041243457591,0.921642139825813,-0.0994922589380876,-5.9348633340666,-0.0414968840699501,"GRK6","G protein-coupled receptor kinase 6",TRUE
+"211543_s_at",0.991363846997029,0.959539372446686,-0.0513086081311727,-5.93840133271463,-0.0183929597123562,"GRK6","G protein-coupled receptor kinase 6",TRUE
+"1552929_at",0.878774484192636,0.531914612014549,-0.635026810675894,-5.74515672783992,-0.436029279097221,"GRK7","G protein-coupled receptor kinase 7",TRUE
+"210940_s_at",0.792344934473527,0.323481930252534,1.00982217424357,-5.4548477396934,0.769402783505809,"GRM1","glutamate metabotropic receptor 1",TRUE
+"210939_s_at",0.867216713941453,0.49929210720353,0.686868509613219,-5.71246880286205,0.299002369334113,"GRM1","glutamate metabotropic receptor 1",TRUE
+"207299_s_at",0.927751423245943,0.682925303971077,-0.413901652965602,-5.85658518794211,-0.22295556266922,"GRM1","glutamate metabotropic receptor 1",TRUE
+"241802_x_at",0.554642754132296,0.0510779110815265,2.06248364878376,-4.05630489145309,1.4447323872729,"GRM2","glutamate metabotropic receptor 2",TRUE
+"208465_at",0.991059530537351,0.95832309902151,-0.0528524588502598,-5.93832301875303,-0.034657082288466,"GRM2","glutamate metabotropic receptor 2",TRUE
+"205814_at",0.562894650172193,0.055553352214525,2.02075002024703,-4.12528005249746,1.27443050121931,"GRM3","glutamate metabotropic receptor 3",TRUE
+"210234_at",0.622917527985155,0.0938069577690133,-1.75084934391032,-4.54764536631767,-1.12549997902623,"GRM4","glutamate metabotropic receptor 4",TRUE
+"1565389_s_at",0.740610299769501,0.230435971123031,1.23316967402286,-5.22496119394074,0.924549737039799,"GRM5","glutamate metabotropic receptor 5",TRUE
+"214217_at",0.891355369164194,0.560734667076405,0.590646056876396,-5.77117898315692,0.527627477084171,"GRM5","glutamate metabotropic receptor 5",TRUE
+"207235_s_at",0.960029104619887,0.819032880470909,0.231523562270891,-5.91360903016278,0.129787639727847,"GRM5","glutamate metabotropic receptor 5",TRUE
+"208035_at",0.931582451098271,0.697658074560659,0.393573065272406,-5.86451784943977,0.130529846086006,"GRM6","glutamate metabotropic receptor 6",TRUE
+"216256_at",0.815028680506658,0.365918717705483,0.92306129799501,-5.53299340425976,0.396568179755824,"GRM8","glutamate metabotropic receptor 8",TRUE
+"216255_s_at",0.892689821944014,0.56520329868806,-0.583872777543395,-5.77499031883532,-0.398547334196468,"GRM8","glutamate metabotropic receptor 8",TRUE
+"216992_s_at",0.895457620469779,0.574506637801699,0.569858830591613,-5.78274086686143,0.460577048044303,"GRM8","glutamate metabotropic receptor 8",TRUE
+"200678_x_at",0.731054546207485,0.214103203438388,1.27907964228019,-5.1727728288928,0.430827925336201,"GRN","granulin",TRUE
+"216041_x_at",0.804466873655748,0.343204860203207,0.968589766629931,-5.49278472937334,0.336978395070872,"GRN","granulin",TRUE
+"211284_s_at",0.834111777111252,0.411998585325404,0.836148267825069,-5.60477539768518,0.345879042630656,"GRN","granulin",TRUE
+"206326_at",0.805746717966166,0.345928182428974,0.963025396985477,-5.49779397388521,0.591628179978625,"GRP","gastrin releasing peptide",TRUE
+"212432_at",0.774230543658252,0.289681122792624,-1.08478174269983,-5.38222948328506,-0.354663759210016,"GRPEL1","GrpE like 1, mitochondrial",TRUE
+"212434_at",0.790309297261437,0.319952300315692,-1.01738366240226,-5.44773496228577,-0.345730009346438,"GRPEL1","GrpE like 1, mitochondrial",TRUE
+"238427_at",0.917906507115144,0.65140723150571,0.458007457603925,-5.83802510894904,0.193001386625696,"GRPEL2","GrpE like 2, mitochondrial",TRUE
+"226881_at",0.988303773451367,0.944301128086652,0.0706614381995043,-5.93725184820599,0.0222827773258683,"GRPEL2","GrpE like 2, mitochondrial",TRUE
+"207929_at",0.715677574404058,0.191465730992944,-1.34741281040465,-5.09209971629972,-0.784103127378953,"GRPR","gastrin releasing peptide receptor",TRUE
+"215030_at",0.554642754132296,0.0512391504549104,-2.06092437089153,-4.05889860644626,-0.778587945033388,"GRSF1","G-rich RNA sequence binding factor 1",TRUE
+"201501_s_at",0.680160698079016,0.147381598175751,-1.50135449727473,-4.8976744809859,-0.479522901862506,"GRSF1","G-rich RNA sequence binding factor 1",TRUE
+"221917_s_at",0.850536169066796,0.453313124040467,0.763338786052946,-5.65979507171238,0.27247871773659,"GRSF1","G-rich RNA sequence binding factor 1",TRUE
+"201520_s_at",0.951893068371814,0.779548167156925,-0.283338125908759,-5.90065728016316,-0.0939832766756314,"GRSF1","G-rich RNA sequence binding factor 1",TRUE
+"206712_at",0.590910793348582,0.068466755845693,-1.91517695330795,-4.29551804359498,-2.10884636557496,"GRTP1","growth hormone regulated TBC protein 1",TRUE
+"229377_at",0.885029460971826,0.54573309350011,0.613592458809078,-5.75795146333137,0.454961191177789,"GRTP1","growth hormone regulated TBC protein 1",TRUE
+"1559653_at",0.955029554963858,0.794731315806961,0.263327797761126,-5.90596609979205,0.310318230481018,"GRTP1-AS1","GRTP1 antisense RNA 1",TRUE
+"221549_at",0.879447209955825,0.533918875303355,-0.631899528123494,-5.7470498326069,-0.272574736623929,"GRWD1","glutamate rich WD repeat containing 1",TRUE
+"231992_x_at",0.979588787486838,0.902140447614349,-0.124374241428253,-5.93215193205291,-0.0366107346290931,"GS1-124K5.11","RAB guanine nucleotide exchange factor 1 pseudogene",TRUE
+"1565846_at",0.982407245834066,0.915048047650601,-0.107897584462671,-5.93401473631184,-0.0464144570616711,"GS1-124K5.11","RAB guanine nucleotide exchange factor 1 pseudogene",TRUE
+"1569296_a_at",0.983136574792668,0.917902878149712,0.104257661787577,-5.93439065648561,0.0776319922865483,"GS1-124K5.11","RAB guanine nucleotide exchange factor 1 pseudogene",TRUE
+"239896_at",0.511772009810211,0.0341641223244997,-2.25751051777974,-3.72220534287859,-1.03920447342191,"GS1-124K5.4","uncharacterized LOC100289098",TRUE
+"1559678_s_at",0.622917527985155,0.0937580698400313,1.75112722372748,-4.54723288320741,1.68090330975858,"GS1-24F4.2","uncharacterized LOC100652791",TRUE
+"230277_at",0.973071267819624,0.870357462914144,0.165106270078236,-5.92641481611716,0.121542177168974,"GS1-259H13.2","transmembrane protein 225-like",TRUE
+"242226_at",0.792305111661886,0.323387704668343,-1.010023283298,-5.45465918665451,-0.601050580626098,"GS1-279B7.1","microtubule associated protein 1 light chain 3 beta pseudogene",TRUE
+"216543_at",0.843816788557882,0.439616835463078,0.787004483286196,-5.64242870113741,0.540358055666178,"GS1-600G8.3","unknown transcript",TRUE
+"213142_x_at",0.589837057564116,0.06801805548905,1.91853788288981,-4.29019497300946,1.19539704370654,"GSAP","gamma-secretase activating protein",TRUE
+"222150_s_at",0.624995428438293,0.096332118291836,1.73666216646793,-4.56864035145094,1.46165338083388,"GSAP","gamma-secretase activating protein",TRUE
+"1552338_at",0.995025131654789,0.976633821251272,0.0296218773355694,-5.93925611350658,0.0128780070402201,"GSC","goosecoid homeobox",TRUE
+"221441_at",0.947969282616012,0.76321625684785,-0.304995406836342,-5.89447708358523,-0.291958144415006,"GSC2","goosecoid homeobox 2",TRUE
+"219233_s_at",0.936143408699214,0.715248899766178,0.369519236372483,-5.87339565485115,0.477660909376072,"GSDMB","gasdermin B",TRUE
+"215659_at",0.975398143273847,0.88110266640556,0.151307073615182,-5.92853888794253,0.21272461285565,"GSDMB","gasdermin B",TRUE
+"240701_at",0.9941582295447,0.973395666736356,0.0337284933140839,-5.93912940743714,0.0329914963503164,"GSDMB","gasdermin B",TRUE
+"234305_s_at",0.632216562924782,0.103256099304085,1.69932884456641,-4.62327967168175,0.819793342418482,"GSDMC","gasdermin C",TRUE
+"218154_at",0.719333457476224,0.195306335863127,1.33539068959659,-5.10654928486494,1.43819135117501,"GSDMD","gasdermin D",TRUE
+"212056_at",0.594972224548427,0.0715867975002116,-1.89232697405036,-4.33153573583119,-1.48530325382606,"GSE1","Gse1 coiled-coil protein",TRUE
+"212057_at",0.643082025527735,0.113666986272211,-1.64701045347898,-4.69834053302437,-1.48201593347857,"GSE1","Gse1 coiled-coil protein",TRUE
+"232988_at",0.940323871449272,0.733323631545048,-0.34503278250242,-5.88186553274715,-0.133787674058552,"GSE1","Gse1 coiled-coil protein",TRUE
+"241553_at",0.744706562599365,0.236215232674915,1.21751896962547,-5.24237667186255,0.859479865334846,"GSG1","germ cell associated 1",TRUE
+"221252_s_at",0.7504331107677,0.243405227002367,1.19844672176855,-5.26333891150976,0.887166051004316,"GSG1","germ cell associated 1",TRUE
+"236701_at",0.812302873476553,0.358076781274672,-0.938558888238296,-5.51950600115192,-0.634210156318648,"GSG1L","GSG1 like",TRUE
+"223759_s_at",0.541849190341655,0.0452607159501292,2.12192053538306,-3.95649468436667,0.659604685444728,"GSG2","germ cell associated 2, haspin",TRUE
+"202210_x_at",0.86843578959442,0.504436798017039,0.678569950244202,-5.71786637123849,0.443869667282955,"GSK3A","glycogen synthase kinase 3 alpha",TRUE
+"632_at",0.876664891408244,0.525623070275176,-0.644885360728623,-5.73913003872797,-0.14743640597837,"GSK3A","glycogen synthase kinase 3 alpha",TRUE
+"226191_at",0.843087230275826,0.437116397890559,-0.791373380936414,-5.63916808255379,-0.261474596401554,"GSK3B","glycogen synthase kinase 3 beta",TRUE
+"240562_at",0.913572663544659,0.63729464509352,0.478054032661017,-5.82898104554937,0.287492536943852,"GSK3B","glycogen synthase kinase 3 beta",TRUE
+"226183_at",0.941311073534434,0.737464475522169,-0.339453731198458,-5.88371507634957,-0.117134595971645,"GSK3B","glycogen synthase kinase 3 beta",TRUE
+"209945_s_at",0.976433695486417,0.888246597392006,0.142149489122858,-5.92984644040291,0.0533184501352419,"GSK3B","glycogen synthase kinase 3 beta",TRUE
+"242336_at",0.993474831312851,0.969403834369671,-0.0387917468067617,-5.93895057491372,-0.0133852199442455,"GSK3B","glycogen synthase kinase 3 beta",TRUE
+"223239_at",0.565043084457947,0.0562048984557825,-2.01492624648447,-4.13483111061228,-0.719181226640233,"GSKIP","GSK3B interacting protein",TRUE
+"227958_s_at",0.208428274543958,0.00238080443500138,3.42912517153135,-1.42049789110131,1.8457388510247,"GSN","gelsolin",TRUE
+"234431_at",0.782311754252508,0.304511362670359,1.05116855771192,-5.41537041491523,0.714744023918817,"GSN","gelsolin",TRUE
+"227957_at",0.870808709484996,0.510196258913039,-0.66933613273435,-5.72379846951628,-0.357414440844624,"GSN","gelsolin",TRUE
+"214040_s_at",0.94079969729523,0.735040548591989,-0.342718197167546,-5.88263647268642,-0.38376373120733,"GSN","gelsolin",TRUE
+"200696_s_at",0.942303845415102,0.740368103878801,0.335548160764415,-5.88499209140696,0.211461621455644,"GSN","gelsolin",TRUE
+"1564525_at",0.96567534940972,0.839479640739717,-0.204953468020675,-5.91924462931415,-0.0840993636382232,"GSN","gelsolin",TRUE
+"234240_at",0.97928472590149,0.899832612240577,0.127323797155781,-5.93179061352788,0.0892136706763598,"GSN","gelsolin",TRUE
+"221072_at",0.615637099066718,0.0860845547302206,1.79636962599024,-4.47943583643687,1.22303871228334,"GSN-AS1","GSN antisense RNA 1",TRUE
+"217595_at",0.580630437263151,0.0633546808411476,-1.95467389856201,-4.23255655839341,-0.901351724255481,"GSPT1","G1 to S phase transition 1",TRUE
+"225276_at",0.610033432202476,0.0822370301870543,-1.8203785331884,-4.44294765574756,-0.577282740793772,"GSPT1","G1 to S phase transition 1",TRUE
+"234975_at",0.612280302313181,0.083873813679529,-1.81004858180578,-4.45868978833683,-0.783179448642496,"GSPT1","G1 to S phase transition 1",TRUE
+"201912_s_at",0.758920166935337,0.256315292274887,-1.16523618032583,-5.2991518586093,-0.37249768272029,"GSPT1","G1 to S phase transition 1",TRUE
+"215438_x_at",0.773234064853267,0.284282493157953,-1.09732446287296,-5.36962450460834,-0.308760976755856,"GSPT1","G1 to S phase transition 1",TRUE
+"240452_at",0.86565139019074,0.495594326762699,-0.692863163454565,-5.70853075571925,-0.224932654840584,"GSPT1","G1 to S phase transition 1",TRUE
+"205541_s_at",0.715119690416591,0.190868617142191,1.34929891358807,-5.0898229325571,1.54971550976151,"GSPT2","G1 to S phase transition 2",TRUE
+"225609_at",0.864894115958506,0.493990186614581,-0.695471643947181,-5.70680697517275,-0.367112342361644,"GSR","glutathione-disulfide reductase",TRUE
+"205770_at",0.8920930097751,0.562981076750936,-0.587237620450898,-5.77310223066798,-0.369816145455751,"GSR","glutathione-disulfide reductase",TRUE
+"201415_at",0.84132852755264,0.431566527366097,-0.801125737019424,-5.63182839992273,-0.468925694608124,"GSS","glutathione synthetase",TRUE
+"211630_s_at",0.867026157046741,0.498553422662164,-0.688064003476036,-5.71168606040658,-0.320401806023098,"GSS","glutathione synthetase",TRUE
+"215766_at",0.951290104727482,0.77710875605941,0.286563926323525,-5.89976535961127,0.075095515061264,"GSTA1","glutathione S-transferase alpha 1",TRUE
+"203924_at",0.994114182402977,0.972952490247259,0.0342905727814974,-5.93911078701902,0.0332957350368019,"GSTA1","glutathione S-transferase alpha 1",TRUE
+"222102_at",0.951339758531576,0.777288339820129,-0.286326344930906,-5.89983139162965,-0.231965399582835,"GSTA3","glutathione S-transferase alpha 3",TRUE
+"202967_at",0.830635993561085,0.403527202830754,-0.851636164771197,-5.59246684648873,-0.574688097918504,"GSTA4","glutathione S-transferase alpha 4",TRUE
+"235405_at",0.900171779891306,0.594869486796731,-0.539578370409333,-5.79886388195416,-0.531986625209659,"GSTA4","glutathione S-transferase alpha 4",TRUE
+"235387_at",0.535243600695458,0.0428390671539703,-2.14871317567293,-3.9109130030249,-0.942591495499146,"GSTCD","glutathione S-transferase C-terminal domain containing",TRUE
+"1554518_at",0.647518308302168,0.118718866542379,-1.62306598619728,-4.73209476546118,-0.420669466074327,"GSTCD","glutathione S-transferase C-terminal domain containing",TRUE
+"220063_at",0.940227139261806,0.732509141304522,0.346131472867473,-5.88149778651568,0.129135453025549,"GSTCD","glutathione S-transferase C-terminal domain containing",TRUE
+"217751_at",0.898352365956814,0.587564345800012,0.550381385066412,-5.79320980269168,0.233811342615446,"GSTK1","glutathione S-transferase kappa 1",TRUE
+"215333_x_at",0.943010360246042,0.744352960532939,-0.330196904401966,-5.88671806774756,-0.258617672647659,"GSTM1","glutathione S-transferase mu 1",TRUE
+"204550_x_at",0.949495693037756,0.771804976418418,-0.293588257411523,-5.89778850975247,-0.261778583630809,"GSTM1","glutathione S-transferase mu 1",TRUE
+"204418_x_at",0.947778780715578,0.762206382288218,-0.306339364824402,-5.89407870304304,-0.240546950210616,"GSTM2","glutathione S-transferase mu 2 (muscle)",TRUE
+"202554_s_at",0.594303508881191,0.0711883577779862,-1.89519579837086,-4.32703026315513,-2.54853801978839,"GSTM3","glutathione S-transferase mu 3",TRUE
+"235867_at",0.875604460253057,0.523094003675721,-0.648866425319029,-5.73667107010076,-0.409857285515293,"GSTM3","glutathione S-transferase mu 3",TRUE
+"204149_s_at",0.899808883319249,0.593252683332788,-0.541963701838431,-5.79762481820208,-0.537913033975502,"GSTM4","glutathione S-transferase mu 4",TRUE
+"210912_x_at",0.925511384407886,0.677440260933234,-0.421515115719186,-5.85351311514974,-0.176293989665401,"GSTM4","glutathione S-transferase mu 4",TRUE
+"205752_s_at",0.990810941805126,0.953687061727265,0.0587383544113452,-5.93800315803528,0.016779917013757,"GSTM5","glutathione S-transferase mu 5",TRUE
+"201470_at",0.454713655038042,0.0220613918581696,2.46199208231107,-3.35298528255301,0.928171880898677,"GSTO1","glutathione S-transferase omega 1",TRUE
+"1557915_s_at",0.522016286799917,0.0379847720107611,2.20682035429723,-3.8108350680624,0.933633131976114,"GSTO1","glutathione S-transferase omega 1",TRUE
+"229155_at",0.877223961993707,0.526487853133312,-0.643526490412308,-5.73996603915491,-0.573801204108958,"GSTO2","glutathione S-transferase omega 2",TRUE
+"227163_at",0.993225426079816,0.9683203871539,0.0401661685264358,-5.93889772207662,0.0454450680132954,"GSTO2","glutathione S-transferase omega 2",TRUE
+"200824_at",0.21219412234776,0.00249936926917161,3.40883259992906,-1.46320999084019,4.90461899045516,"GSTP1","glutathione S-transferase pi 1",TRUE
+"232193_at",0.925389506721126,0.676820836153433,0.422376488213333,-5.8531620803911,0.415836497569831,"GSTT1","glutathione S-transferase theta 1",TRUE
+"203815_at",0.988164716416515,0.943554065621155,0.0716108699442546,-5.93718607281143,0.130476872623097,"GSTT1","glutathione S-transferase theta 1",TRUE
+"205439_at",0.99514093116831,0.9778048705911,-0.0281368890734327,-5.93929788776186,-0.0524587985054348,"GSTT2","glutathione S-transferase theta 2 (gene/pseudogene)",TRUE
+"207215_at",0.869153739254366,0.506088311712885,0.675916142639311,-5.71957922586337,0.235769340168167,"GSTTP1","glutathione S-transferase theta pseudogene 1",TRUE
+"209531_at",0.774230543658252,0.288284591560961,-1.08801005119648,-5.37899748997945,-0.829314377669551,"GSTZ1","glutathione S-transferase zeta 1",TRUE
+"1555676_s_at",0.899808883319249,0.592414327254724,0.543201812835628,-5.79697958529328,0.345387093957461,"GSX1","GS homeobox 1",TRUE
+"234791_at",0.990810941805126,0.954609984429411,0.0575664524630644,-5.93806953286296,0.0233466744448059,"GSX1","GS homeobox 1",TRUE
+"230338_x_at",0.677013732819214,0.144377513796794,1.51314395173678,-4.88208300895149,0.572368950043097,"GSX2","GS homeobox 2",TRUE
+"220853_at",0.606900628956089,0.0806307169576622,1.83069083622605,-4.42716816178773,0.48621869078317,"GTDC1","glycosyltransferase like domain containing 1",TRUE
+"236457_at",0.614034563169767,0.0850046201853126,1.80301330949364,-4.46937399958569,0.98878462093729,"GTDC1","glycosyltransferase like domain containing 1",TRUE
+"239390_at",0.833756343506065,0.411340849497306,0.837343485934188,-5.6038330449073,0.421921184675626,"GTDC1","glycosyltransferase like domain containing 1",TRUE
+"219770_at",0.852094603401457,0.457711946518698,0.755830148023171,-5.66520037631471,0.288178952555491,"GTDC1","glycosyltransferase like domain containing 1",TRUE
+"238585_at",0.931209631927021,0.695248467673127,0.396886139673121,-5.86325184032639,0.116129257070346,"GTDC1","glycosyltransferase like domain containing 1",TRUE
+"225433_at",0.693742297578797,0.162997847164815,-1.44304400504133,-4.97334148424676,-0.456002099208089,"GTF2A1","general transcription factor IIA subunit 1",TRUE
+"206521_s_at",0.877546037473893,0.527985539336226,-0.641175990709051,-5.74140810671919,-0.208410838221445,"GTF2A1","general transcription factor IIA subunit 1",TRUE
+"1552585_s_at",0.986455005400648,0.937028147412458,0.0799075399715988,-5.93657395644654,0.0504611026436015,"GTF2A1L","general transcription factor IIA subunit 1 like",TRUE
+"202678_at",0.644844656970274,0.115169786471234,-1.63979574154782,-4.70855097939822,-0.477290808473477,"GTF2A2","general transcription factor IIA subunit 2",TRUE
+"243985_at",0.85334340854827,0.460995165877032,-0.750253989997608,-5.66918181116678,-0.299098228177543,"GTF2A2","general transcription factor IIA subunit 2",TRUE
+"230376_at",0.983364220761052,0.918941132279686,-0.102934243135719,-5.93452414093702,-0.028674764372111,"GTF2A2","general transcription factor IIA subunit 2",TRUE
+"208066_s_at",0.51470556386048,0.0351640197769002,2.24376396604977,-3.74636021319041,0.589394929368812,"GTF2B","general transcription factor IIB",TRUE
+"205930_at",0.468735421183467,0.0250876772078754,-2.40260801678788,-3.46205497471999,-0.911603896167215,"GTF2E1","general transcription factor IIE subunit 1",TRUE
+"202680_at",0.960699983781935,0.82162471406755,0.228146493713883,-5.91436319586521,0.0653601400150219,"GTF2E2","general transcription factor IIE subunit 2",TRUE
+"202354_s_at",0.838503236630356,0.423549326933575,0.815352053023358,-5.62097019038124,0.305288096572298,"GTF2F1","general transcription factor IIF subunit 1",TRUE
+"202356_s_at",0.902424542997102,0.601352944835611,-0.530044630454137,-5.80376311001546,-0.15765238002313,"GTF2F1","general transcription factor IIF subunit 1",TRUE
+"202355_s_at",0.986740053670029,0.938210670874991,0.0784037399548429,-5.93668987582697,0.0237635527619489,"GTF2F1","general transcription factor IIF subunit 1",TRUE
+"209595_at",0.630603891142543,0.101507173825173,1.70855272758995,-4.60986264763658,0.687576808956109,"GTF2F2","general transcription factor IIF subunit 2",TRUE
+"202451_at",0.771527793162888,0.280697192005836,1.10574971075338,-5.36108507581261,0.424167223226343,"GTF2H1","general transcription factor IIH subunit 1",TRUE
+"242656_at",0.774230543658252,0.28714892043195,1.09064365737189,-5.37635453815441,0.58391855463707,"GTF2H1","general transcription factor IIH subunit 1",TRUE
+"202453_s_at",0.776743077119289,0.294258163760973,1.07427897874716,-5.39268491228468,0.406717038368646,"GTF2H1","general transcription factor IIH subunit 1",TRUE
+"215470_at",0.960701710689937,0.821643762113802,0.228121684864239,-5.91436869537303,0.14611376812472,"GTF2H2B","general transcription factor IIH subunit 2B (pseudogene)",TRUE
+"230177_at",0.91876780831279,0.654779101871138,-0.453246177272097,-5.8401173979618,-0.299609811728978,"GTF2H2B///GTF2H2","general transcription factor IIH subunit 2B (pseudogene)///general transcription factor IIH subunit 2",TRUE
+"221540_x_at",0.920119557710459,0.659861825856,-0.446089083590524,-5.84322216328769,-0.167688265839647,"GTF2H2C_2///GTF2H2C///GTF2H2B///GTF2H2","GTF2H2 family member C, copy 2///GTF2H2 family member C///general transcription factor IIH subunit 2B (pseudogene)///general transcription factor IIH subunit 2",TRUE
+"223758_s_at",0.784498961298069,0.307631234791383,-1.04424643611092,-5.42207906598338,-0.461313577176918,"GTF2H2C///GTF2H2B///GTF2H2","GTF2H2 family member C///general transcription factor IIH subunit 2B (pseudogene)///general transcription factor IIH subunit 2",TRUE
+"222104_x_at",0.75466931720949,0.24814633284934,1.1861008924993,-5.27675469996937,0.34343488309289,"GTF2H3","general transcription factor IIH subunit 3",TRUE
+"239346_at",0.94333312187812,0.74570747271538,0.328380177629867,-5.88729778594436,0.101652411214012,"GTF2H3","general transcription factor IIH subunit 3",TRUE
+"203577_at",0.828607509614823,0.399182870649694,0.859659437492323,-5.58600778888051,0.257335130604703,"GTF2H4","general transcription factor IIH subunit 4",TRUE
+"232905_at",0.687545925823023,0.156491050853608,1.46676440605957,-4.94285316979667,1.64815630986298,"GTF2H5","general transcription factor IIH subunit 5",TRUE
+"244294_at",0.750020866111355,0.242846551092755,1.19991335993409,-5.26173713476073,0.472599436825292,"GTF2H5","general transcription factor IIH subunit 5",TRUE
+"1558934_a_at",0.786455312223125,0.31216245973212,-1.03428077899142,-5.43166732961728,-0.744841698735352,"GTF2H5","general transcription factor IIH subunit 5",TRUE
+"213357_at",0.863648730667543,0.489061332422456,0.703516910537338,-5.70145144812453,0.244856293894658,"GTF2H5","general transcription factor IIH subunit 5",TRUE
+"210892_s_at",0.91539387234353,0.643233379841353,0.469594450253277,-5.83284385927389,0.192066576739595,"GTF2I","general transcription factor IIi",TRUE
+"1558504_at",0.719675699464475,0.195585939064337,1.33452272125006,-5.10758830098448,0.620214852585299,"GTF2IP12","general transcription factor IIi pseudogene 12",TRUE
+"227922_x_at",0.769258076576208,0.275874518323104,1.11720684325615,-5.34937968761998,0.519046016546746,"GTF2IP20","general transcription factor IIi pseudogene 20",TRUE
+"210891_s_at",0.757850812302788,0.253961455564914,-1.17119681831733,-5.29278890028987,-0.35163080983558,"GTF2IP4///GTF2IP1///GTF2I","general transcription factor IIi pseudogene 4///general transcription factor IIi pseudogene 1///general transcription factor IIi",TRUE
+"201065_s_at",0.87825255145971,0.530362325977376,-0.63745325279289,-5.74368168531657,-0.181822416657322,"GTF2IP4///GTF2IP1///GTF2I","general transcription factor IIi pseudogene 4///general transcription factor IIi pseudogene 1///general transcription factor IIi",TRUE
+"1570044_at",0.820442898002464,0.37952705580756,0.896684461570676,-5.55547271943453,0.262499688330107,"GTF2IP7","general transcription factor IIi pseudogene 7",TRUE
+"218412_s_at",0.915580532396172,0.644202827086611,-0.468216808450242,-5.83346652625442,-0.161273244623091,"GTF2IRD1","GTF2I repeat domain containing 1",TRUE
+"1557289_s_at",0.827768017240356,0.396688368102781,-0.864291767617991,-5.58225290394555,-0.729536627978207,"GTF2IRD2","GTF2I repeat domain containing 2",TRUE
+"228765_at",0.923050713409153,0.670180172284519,-0.431631604601585,-5.84934591943426,-0.195727392897826,"GTF2IRD2","GTF2I repeat domain containing 2",TRUE
+"215569_at",0.931501755169233,0.697053089963034,-0.394404462275428,-5.86420113425488,-0.161882833368781,"GTF2IRD2B","GTF2I repeat domain containing 2B",TRUE
+"201338_x_at",0.837345289209351,0.420137485325979,-0.821457278968198,-5.61625542631221,-0.247145262750314,"GTF3A","general transcription factor IIIA",TRUE
+"215091_s_at",0.874480604680453,0.520824292269407,-0.652448233597098,-5.73444629267466,-0.218601504713158,"GTF3A","general transcription factor IIIA",TRUE
+"238880_at",0.984663371658531,0.924939606116474,0.0952918517641586,-5.9352616535699,0.0357442566234116,"GTF3A","general transcription factor IIIA",TRUE
+"202320_at",0.348854934125219,0.00913368638916959,-2.85655885972815,-2.59535442225413,-0.885864261725823,"GTF3C1","general transcription factor IIIC subunit 1",TRUE
+"35671_at",0.528768444275307,0.0411989679490226,-2.16764683622161,-3.87848544138955,-0.61191214528812,"GTF3C1","general transcription factor IIIC subunit 1",TRUE
+"212429_s_at",0.733012446828677,0.217524340008642,1.26924628347448,-5.18408836080691,0.423805666379431,"GTF3C2","general transcription factor IIIC subunit 2",TRUE
+"204366_s_at",0.766550448794594,0.267492738467374,1.13747200002224,-5.32841413080455,0.395949465927874,"GTF3C2","general transcription factor IIIC subunit 2",TRUE
+"210620_s_at",0.899808883319249,0.592666244897647,0.542829682642611,-5.79717366876943,0.198927639821022,"GTF3C2","general transcription factor IIIC subunit 2",TRUE
+"1556671_s_at",0.813488170855271,0.364132729232767,-0.926571155580961,-5.52995690110576,-0.434952860003714,"GTF3C2-AS1","GTF3C2 antisense RNA 1",TRUE
+"1556670_at",0.969882914559333,0.857299966186691,-0.18191951761153,-5.92357711058682,-0.0970046664687381,"GTF3C2-AS1","GTF3C2 antisense RNA 1",TRUE
+"1555439_at",0.611470335211357,0.0835536328187297,1.81205547330819,-4.45563648294129,0.702822729894624,"GTF3C3","general transcription factor IIIC subunit 3",TRUE
+"1569058_at",0.768852835478002,0.273293993013188,1.1233973778436,-5.34301054373326,0.960790174947064,"GTF3C3","general transcription factor IIIC subunit 3",TRUE
+"222604_at",0.808328926947236,0.351280856952665,0.952174923258604,-5.50748603473896,0.373131983066333,"GTF3C3","general transcription factor IIIC subunit 3",TRUE
+"218343_s_at",0.959969342594555,0.818897661441197,0.231699823173434,-5.9135693649225,0.0902891286702161,"GTF3C3","general transcription factor IIIC subunit 3",TRUE
+"225543_at",0.547343369043481,0.0477736779470239,-2.09544933538766,-4.00117204802318,-0.685457095380563,"GTF3C4","general transcription factor IIIC subunit 4",TRUE
+"243228_at",0.731548533938014,0.215183545640033,-1.27596143333697,-5.17636911148721,-0.42577347655839,"GTF3C4","general transcription factor IIIC subunit 4",TRUE
+"219198_at",0.854040699678541,0.463253662643052,-0.746431968718032,-5.67189464634873,-0.208219416177643,"GTF3C4","general transcription factor IIIC subunit 4",TRUE
+"217876_at",0.859122424227944,0.475914953636756,-0.725207395991273,-5.68672044189443,-0.225194985163441,"GTF3C5","general transcription factor IIIC subunit 5",TRUE
+"233173_x_at",0.971216837324271,0.863108457407389,-0.174433986673123,-5.92487436306117,-0.0570100049624305,"GTF3C5","general transcription factor IIIC subunit 5",TRUE
+"225083_at",0.85334340854827,0.461452565390435,-0.749479038615684,-5.66973292515773,-0.276145657884168,"GTF3C6","general transcription factor IIIC subunit 6",TRUE
+"226359_at",0.402463840838386,0.0148792787946113,2.64073053612096,-3.01642175601451,1.76525756327532,"GTPBP1","GTP binding protein 1",TRUE
+"205276_s_at",0.63328333988187,0.10447582488769,1.69297423175852,-4.63249129149986,1.05555294431456,"GTPBP1","GTP binding protein 1",TRUE
+"219357_at",0.865854896594418,0.495939889423525,0.692301877935513,-5.70890086557445,0.718980167805039,"GTPBP1","GTP binding protein 1",TRUE
+"205275_at",0.925511384407886,0.678173702077792,-0.420495611053144,-5.85392768314022,-0.275425948050704,"GTPBP1","GTP binding protein 1",TRUE
+"205274_at",0.953902670233338,0.787134396724229,-0.273325755970584,-5.90336183446405,-0.159135883459223,"GTPBP1","GTP binding protein 1",TRUE
+"236633_at",0.984132887597385,0.922252572735521,-0.0987145359603044,-5.93493837931084,-0.0647159545556875,"GTPBP10","GTP binding protein 10",TRUE
+"223788_at",0.728671251879936,0.210251809230139,1.29029570685025,-5.15977535969703,0.709753601019621,"GTPBP2","GTP binding protein 2",TRUE
+"223789_s_at",0.934081042629428,0.708142040999955,0.379209686429095,-5.86988548331362,0.139279572264671,"GTPBP2","GTP binding protein 2",TRUE
+"221050_s_at",0.965584868976477,0.839071175582933,0.205482719695339,-5.91913904184957,0.0802374146026477,"GTPBP2","GTP binding protein 2",TRUE
+"1555062_s_at",0.986342822130003,0.933292988778729,0.084658750816694,-5.93619325141409,0.0526987370238698,"GTPBP3","GTP binding protein 3 (mitochondrial)",TRUE
+"213835_x_at",0.99691715384293,0.98422663095176,-0.0199946228908756,-5.93948876211849,-0.00518279387544851,"GTPBP3","GTP binding protein 3 (mitochondrial)",TRUE
+"218238_at",0.848439423071367,0.448652594418644,0.771342266172677,-5.65397795238951,0.264813406032193,"GTPBP4","GTP binding protein 4",TRUE
+"218239_s_at",0.92365974445982,0.672080748806312,0.428978883531667,-5.85044802362629,0.128369103694405,"GTPBP4","GTP binding protein 4",TRUE
+"217631_at",0.989524702314661,0.948794179367433,0.0649526510634141,-5.93762884487448,0.0249090121038744,"GTPBP4","GTP binding protein 4",TRUE
+"203314_at",0.42796179417767,0.0185856719341175,-2.54035636085764,-3.20690133354747,-1.04898543652506,"GTPBP6","GTP binding protein 6 (putative)",TRUE
+"221046_s_at",0.369429132228615,0.0109911311311493,2.77533331090429,-2.75553865890088,0.926586983043547,"GTPBP8","GTP binding protein 8 (putative)",TRUE
+"223486_at",0.627833079574546,0.0991901626221295,1.72098326960817,-4.59169522899874,0.608983162267991,"GTPBP8","GTP binding protein 8 (putative)",TRUE
+"242685_at",0.726696341943087,0.206835116112147,1.30037961822565,-5.14800755367888,0.814689453793804,"GTPBP8","GTP binding protein 8 (putative)",TRUE
+"204315_s_at",0.739159740280674,0.2257799699548,1.24599681034018,-5.21054472832563,0.41306624639725,"GTSE1","G2 and S-phase expressed 1",TRUE
+"204318_s_at",0.769258076576208,0.275992825425336,1.11692404581002,-5.34966990003632,0.455882336917188,"GTSE1","G2 and S-phase expressed 1",TRUE
+"215942_s_at",0.821424121108148,0.383332990127566,0.889419409459627,-5.56155843824074,0.388404485635814,"GTSE1","G2 and S-phase expressed 1",TRUE
+"229343_at",0.879960488971225,0.535087016205376,0.630079784182498,-5.74814727843158,0.209296717136501,"GTSE1","G2 and S-phase expressed 1",TRUE
+"211040_x_at",0.980135507384952,0.906653807891739,-0.118609128544814,-5.93283373767049,-0.0351965864358306,"GTSE1","G2 and S-phase expressed 1",TRUE
+"1556661_at",0.680160698079016,0.147360489290227,1.5014366503022,-4.8975661720895,0.90520661695946,"GTSE1-AS1","GTSE1 antisense RNA 1 (head to head)",TRUE
+"227711_at",0.298372619814585,0.00549950916492061,3.07574473414706,-2.15406369596561,3.69955810065195,"GTSF1","gametocyte specific factor 1",TRUE
+"232821_at",0.522667179791589,0.0384758521849352,2.2006450662295,-3.82154883484596,1.34928788604895,"GTSF1L","gametocyte specific factor 1 like",TRUE
+"232820_s_at",0.731546623601217,0.21477238783773,1.27714673999646,-5.17500295947626,0.733179931302668,"GTSF1L","gametocyte specific factor 1 like",TRUE
+"1255_g_at",0.758966211371161,0.256482219176594,1.16481501640401,-5.29960037378938,0.65878276208804,"GUCA1A","guanylate cyclase activator 1A",TRUE
+"206062_at",0.84938845819048,0.450459400707657,0.768233511661706,-5.65624427595185,0.501752005975677,"GUCA1A","guanylate cyclase activator 1A",TRUE
+"231700_at",0.850693751204364,0.453594420280948,-0.762857313517677,-5.66014318913796,-0.51050592995793,"GUCA1A","guanylate cyclase activator 1A",TRUE
+"215841_at",0.534005258361339,0.0423004439682297,2.15485780228626,-3.90040862418238,1.10350334175558,"GUCA1B","guanylate cyclase activator 1B",TRUE
+"235528_at",0.962555471240652,0.829095458042078,0.218427388601306,-5.91647212422624,0.126897640390227,"GUCA1B","guanylate cyclase activator 1B",TRUE
+"223928_s_at",0.675622576285316,0.141877253032831,-1.52311033108638,-4.86882660079196,-0.853595467031729,"GUCA1C","guanylate cyclase activator 1C",TRUE
+"233953_at",0.955892698633978,0.799934111218908,-0.256496486948537,-5.90769008509224,-0.171015993233423,"GUCA1C","guanylate cyclase activator 1C",TRUE
+"233902_at",0.995777289890461,0.979659084100739,-0.0257857229031838,-5.93935963595534,-0.0113583196543123,"GUCA1C","guanylate cyclase activator 1C",TRUE
+"207003_at",0.646392036827936,0.117266362961649,-1.62986143154344,-4.72255394057594,-0.967905067861385,"GUCA2A","guanylate cyclase activator 2A",TRUE
+"207502_at",0.763903180119529,0.263869692907863,1.14637606436406,-5.31909722350962,0.853963532346288,"GUCA2B","guanylate cyclase activator 2B",TRUE
+"223039_at",0.594005743610726,0.0710416745765074,-1.89625548080435,-4.32536483066096,-0.854364942776266,"GUCD1","guanylyl cyclase domain containing 1",TRUE
+"206927_s_at",0.713330901550199,0.187987451453127,-1.35846547340829,-5.07871972384008,-1.21069870067536,"GUCY1A2","guanylate cyclase 1 soluble subunit alpha 2",TRUE
+"230665_at",0.769123153940876,0.274456662704109,-1.12060294102726,-5.34588946262657,-0.832810560677443,"GUCY1A2","guanylate cyclase 1 soluble subunit alpha 2",TRUE
+"236335_at",0.899061060612873,0.589261145076585,-0.547866253524345,-5.79453589663018,-0.602905530567453,"GUCY1A2","guanylate cyclase 1 soluble subunit alpha 2",TRUE
+"228731_at",0.910114622481711,0.625736054388843,-0.494621700417872,-5.82122059530236,-0.64860002397497,"GUCY1A2","guanylate cyclase 1 soluble subunit alpha 2",TRUE
+"242342_at",0.974670398319743,0.876232199523373,0.157557929387303,-5.92759960971732,0.132766745426357,"GUCY1A2","guanylate cyclase 1 soluble subunit alpha 2",TRUE
+"228732_at",0.998544717385199,0.993819879328606,0.00783357683980291,-5.93965359220029,0.0078150491977107,"GUCY1A2","guanylate cyclase 1 soluble subunit alpha 2",TRUE
+"227235_at",0.763650705722297,0.26350209614345,1.14728449746572,-5.31814307490219,1.99481188696803,"GUCY1A3","guanylate cyclase 1 soluble subunit alpha",TRUE
+"221942_s_at",0.899298400419117,0.589712767265233,0.547197425412343,-5.79488754071506,0.868647300704446,"GUCY1A3","guanylate cyclase 1 soluble subunit alpha",TRUE
+"239580_at",0.964552175124534,0.836209841808924,-0.209191866521934,-5.91839144479371,-0.254268076598367,"GUCY1A3","guanylate cyclase 1 soluble subunit alpha",TRUE
+"229530_at",0.983126029304171,0.917862713839993,0.104308861352257,-5.93438545809947,0.122965757409978,"GUCY1A3","guanylate cyclase 1 soluble subunit alpha",TRUE
+"220506_at",0.816800680706682,0.368556306397678,-0.917898689717825,-5.53744047382248,-0.715150381742406,"GUCY1B2","guanylate cyclase 1 soluble subunit beta 2 (pseudogene)",TRUE
+"203817_at",0.857945583405123,0.473607930467918,0.729049704065948,-5.68406660983981,0.574423510202114,"GUCY1B3","guanylate cyclase 1 soluble subunit beta",TRUE
+"211555_s_at",0.94333312187812,0.74576192020314,0.328307174049888,-5.88732101526329,0.170482006827192,"GUCY1B3","guanylate cyclase 1 soluble subunit beta",TRUE
+"206312_at",0.931370027472813,0.696494428511871,0.395172451269408,-5.86390798896505,0.256264910478045,"GUCY2C","guanylate cyclase 2C",TRUE
+"207884_at",0.707053429505588,0.178693448356803,1.3888119996406,-5.04151540499736,0.938994740586434,"GUCY2D","guanylate cyclase 2D, retinal",TRUE
+"208053_at",0.923695650933578,0.672173367420106,0.428849691595649,-5.85050152749766,0.190445296621853,"GUCY2F","guanylate cyclase 2F, retinal",TRUE
+"218884_s_at",0.988391891288248,0.944544895128035,0.0703516523554782,-5.93727311990631,0.0279503635622493,"GUF1","GUF1 homolog, GTPase",TRUE
+"222770_s_at",0.989524702314661,0.9488614019849,-0.0648672565363395,-5.93763424331601,-0.0210719583391548,"GUF1","GUF1 homolog, GTPase",TRUE
+"200075_s_at",0.789378278298554,0.316008088859458,-1.02590261394311,-5.43966407577857,-0.372940666131543,"GUK1","guanylate kinase 1",TRUE
+"213621_s_at",0.918993592109901,0.655405891854438,0.452362287593434,-5.84050345413768,0.132609208842027,"GUK1","guanylate kinase 1",TRUE
+"223837_at",0.739340500562926,0.226917217644628,1.24284526791568,-5.21409865487465,0.680155007684617,"GULP1","GULP, engulfment adaptor PTB domain containing 1",TRUE
+"204235_s_at",0.76912869907427,0.274878567883717,1.11959104377117,-5.34693038683151,1.11337992008597,"GULP1","GULP, engulfment adaptor PTB domain containing 1",TRUE
+"204237_at",0.776936981479994,0.295187536846504,1.07216071752508,-5.39478261127064,1.07547150193434,"GULP1","GULP, engulfment adaptor PTB domain containing 1",TRUE
+"215913_s_at",0.782930758690314,0.305438840213748,1.04910551620186,-5.41737400158862,1.15590773587073,"GULP1","GULP, engulfment adaptor PTB domain containing 1",TRUE
+"215915_at",0.874474734833648,0.520545023324275,-0.652889537754619,-5.73417137099395,-0.640010804289663,"GULP1","GULP, engulfment adaptor PTB domain containing 1",TRUE
+"230125_at",0.62932992642067,0.100213331778398,1.71546389733836,-4.59977402696321,0.87669032442574,"GUSB","glucuronidase beta",TRUE
+"202605_at",0.961395512423249,0.825042269629025,-0.223697674944165,-5.91533987360073,-0.0891387556740515,"GUSB","glucuronidase beta",TRUE
+"1558640_a_at",0.997589781442354,0.987755288672397,0.0155211996606496,-5.93956614420155,0.010045381647207,"GUSBP1","glucuronidase, beta pseudogene 1",TRUE
+"226947_at",0.935982562460896,0.714034434023667,0.371172625737589,-5.87280309087814,0.154087675376504,"GUSBP1///GUSBP4","glucuronidase, beta pseudogene 1///glucuronidase, beta pseudogene 4",TRUE
+"235888_at",0.979277201688263,0.89903647258788,-0.128341579739119,-5.93166397372141,-0.10556842303318,"GUSBP1///GUSBP4","glucuronidase, beta pseudogene 1///glucuronidase, beta pseudogene 4",TRUE
+"1556742_at",0.979612118310508,0.903075076389652,0.12318005123711,-5.93229581476314,0.0873529724007733,"GUSBP1///GUSBP4","glucuronidase, beta pseudogene 1///glucuronidase, beta pseudogene 4",TRUE
+"215196_at",0.708894565317004,0.181258564871288,1.38031383310053,-5.05200284906917,0.761888333601509,"GUSBP11","glucuronidase, beta pseudogene 11",TRUE
+"213502_x_at",0.739340500562926,0.226819365642822,-1.24311596142886,-5.21379370350539,-0.965114278297507,"GUSBP11","glucuronidase, beta pseudogene 11",TRUE
+"215816_at",0.966641191718519,0.845039939513288,-0.197754828661258,-5.92065384681407,-0.071197088454797,"GUSBP11","glucuronidase, beta pseudogene 11",TRUE
+"215202_at",0.996898592071515,0.983988413841348,-0.0202966344529554,-5.93948283544298,-0.00906103409103132,"GUSBP11","glucuronidase, beta pseudogene 11",TRUE
+"1555568_at",0.565993041605217,0.0568803761524777,2.00895162290002,-4.1446104851224,1.09018774634688,"GUSBP2","glucuronidase, beta pseudogene 2",TRUE
+"215043_s_at",0.959593724813212,0.817620520708165,-0.233364974578236,-5.91319316224683,-0.259613012010849,"GUSBP3///SMA5///SMA4","glucuronidase, beta pseudogene 3///glucuronidase beta pseudogene///glucuronidase beta pseudogene",TRUE
+"243909_x_at",0.871225851789576,0.511979636360294,0.666488794299851,-5.72561199194023,0.325290525118565,"GUSBP4","glucuronidase, beta pseudogene 4",TRUE
+"240063_at",0.916524270479839,0.647140730898476,0.4640474702452,-5.83534007051467,0.354007460569075,"GUSBP5","glucuronidase, beta pseudogene 5",TRUE
+"215599_at",0.686108994812404,0.154825379575347,1.47296468166309,-4.93481740015527,0.931844576979291,"GUSBP9///GUSBP3","glucuronidase, beta pseudogene 9///glucuronidase, beta pseudogene 3",TRUE
+"220577_at",0.576675680499645,0.0613456704122105,1.97096943920701,-4.2063240954078,0.9104299713871,"GVINP1","GTPase, very large interferon inducible pseudogene 1",TRUE
+"1562364_at",0.726636642789909,0.206168307479139,1.30236265067548,-5.14568423504684,1.03455008382036,"GVINP1","GTPase, very large interferon inducible pseudogene 1",TRUE
+"1564403_at",0.754682106570676,0.248217043314426,-1.18591810461134,-5.27695241990531,-0.681810152275585,"GVQW1","GVQW motif containing 1",TRUE
+"1558651_at",0.615821255316333,0.0866927366977013,1.79265973916346,-4.48504271194671,1.22692223569866,"GVQW2","GVQW motif containing 2",TRUE
+"226868_at",0.574669559819863,0.0606043837571345,-1.9771015578963,-4.19641438052505,-0.834170844946481,"GXYLT1","glucoside xylosyltransferase 1",TRUE
+"232021_at",0.778295711796067,0.297840558649115,-1.06613999073813,-5.40072466474377,-0.40252997793506,"GXYLT1","glucoside xylosyltransferase 1",TRUE
+"235371_at",0.918041148686074,0.651749302158109,-0.457523945204164,-5.83823856038887,-0.542202589741135,"GXYLT2","glucoside xylosyltransferase 2",TRUE
+"235733_at",0.93613089056626,0.714336097612246,-0.370761838817672,-5.87295055796824,-0.283677695001001,"GXYLT2","glucoside xylosyltransferase 2",TRUE
+"201554_x_at",0.758189649141895,0.255111760234434,-1.16827878785891,-5.29590743859903,-0.43700665797277,"GYG1","glycogenin 1",TRUE
+"211275_s_at",0.803135302652907,0.341005918987858,-0.973104744878222,-5.48870082308418,-0.366242054617423,"GYG1","glycogenin 1",TRUE
+"210963_s_at",0.892502176012097,0.564753503127399,0.58455329850773,-5.77460931018234,0.455637889163579,"GYG2","glycogenin 2",TRUE
+"215695_s_at",0.920486752529216,0.661424801459373,-0.443892990914458,-5.84416511501576,-0.425818558339081,"GYG2","glycogenin 2",TRUE
+"210964_s_at",0.922168942129244,0.66766681851016,-0.435144450922527,-5.84787619753628,-0.465921223592891,"GYG2","glycogenin 2",TRUE
+"205837_s_at",0.623667408398064,0.0951930763679779,1.74302177832492,-4.5592446761542,1.48210429728589,"GYPA","glycophorin A (MNS blood group)",TRUE
+"205838_at",0.835973067952943,0.417184404807667,-0.826766768577305,-5.61212838876448,-0.489198396354608,"GYPA","glycophorin A (MNS blood group)",TRUE
+"1559520_at",0.862589597763622,0.485535953137234,0.709299974507633,-5.69756554166011,0.698740061358923,"GYPA","glycophorin A (MNS blood group)",TRUE
+"211820_x_at",0.863408882018863,0.487837420415119,0.705521892664237,-5.7001076416989,0.45752084931968,"GYPA","glycophorin A (MNS blood group)",TRUE
+"211821_x_at",0.973493137611142,0.87226233880988,0.162657675867965,-5.92680520851224,0.105981506721515,"GYPA","glycophorin A (MNS blood group)",TRUE
+"207459_x_at",0.317138771443924,0.00689091651532477,2.97886368899542,-2.35063448468199,1.70784393011373,"GYPB","glycophorin B (MNS blood group)",TRUE
+"214407_x_at",0.637485146909712,0.108524578609727,1.6723221679874,-4.66224834908579,1.05037198705569,"GYPB","glycophorin B (MNS blood group)",TRUE
+"216398_at",0.886023097762234,0.548654581893354,0.609098018890544,-5.7605806125062,0.246354196994019,"GYPB","glycophorin B (MNS blood group)",TRUE
+"216833_x_at",0.990810941805126,0.95457126307652,0.0576156181034968,-5.9380667750652,0.0266945138533767,"GYPB","glycophorin B (MNS blood group)",TRUE
+"202947_s_at",0.57460012602512,0.0605610371085316,1.97746218361155,-4.19583094830592,1.18306291833544,"GYPC","glycophorin C (Gerbich blood group)",TRUE
+"207854_at",0.794911622610881,0.327104518921033,1.00212106448512,-5.46204243453728,0.911960435612313,"GYPE","glycophorin E (MNS blood group)",TRUE
+"1561136_at",0.948429371744093,0.765765910937582,-0.301604827690663,-5.89547441567989,-0.296114064911055,"GYPE","glycophorin E (MNS blood group)",TRUE
+"1561137_s_at",0.986342822130003,0.93534557000036,-0.0820475785855165,-5.93640519848292,-0.0717177778441245,"GYPE","glycophorin E (MNS blood group)",TRUE
+"201673_s_at",0.835952408568777,0.416113993015302,-0.828697157322117,-5.61062173880036,-0.263828856955998,"GYS1","glycogen synthase 1",TRUE
+"214621_at",0.538039282264231,0.043714394283396,2.13887466096801,-3.92769293805006,1.72342606034496,"GYS2","glycogen synthase 2",TRUE
+"225884_s_at",0.594005743610726,0.070774247638138,-1.89819239337038,-4.32231903266176,-0.738284470058082,"GZF1","GDNF inducible zinc finger protein 1",TRUE
+"234055_s_at",0.657015752622694,0.125700562781472,-1.5913416458616,-4.77622715813707,-1.25292236621314,"GZF1","GDNF inducible zinc finger protein 1",TRUE
+"205488_at",0.615637099066718,0.0860582680104239,-1.79653048334808,-4.47919253690034,-1.07054896645306,"GZMA","granzyme A",TRUE
+"210164_at",0.985425981490741,0.92882531470329,0.0903443721193902,-5.93570880184919,0.0579334672778407,"GZMB","granzyme B",TRUE
+"210321_at",0.975196332002567,0.879430606756462,0.153452320257418,-5.92822080985107,0.097789703258365,"GZMH","granzyme H",TRUE
+"206666_at",0.993615552413264,0.970177725904676,-0.0378100632038622,-5.93898719885787,-0.0240079734506224,"GZMK","granzyme K",TRUE
+"207460_at",0.94118897722809,0.73681325605421,0.340330401477237,-5.88342642061221,0.261129350864366,"GZMM","granzyme M",TRUE
+"208886_at",0.745375087681269,0.236965885214007,-1.21550748098529,-5.24460102373851,-0.530313298398031,"H1F0","H1 histone family member 0",TRUE
+"238373_at",0.835952408568777,0.416484341326205,0.828028914484624,-5.61114366805889,0.293999421670643,"H1FNT","H1 histone family member N, testis specific",TRUE
+"238374_at",0.839519981963042,0.427838560177508,-0.807720272608714,-5.62681744084241,-0.614609922264855,"H1FNT","H1 histone family member N, testis specific",TRUE
+"236876_at",0.993474831312851,0.969488798672782,0.0386839674564296,-5.93895464173413,0.0252625260891675,"H1FNT","H1 histone family member N, testis specific",TRUE
+"1553064_at",0.314126572995991,0.00669492842850569,2.9913054249982,-2.32551874937005,1.62887375959259,"H1FOO","H1 histone family member O, oocyte specific",TRUE
+"204805_s_at",0.27101318038741,0.00425293660306169,-3.18519430068961,-1.92941670658858,-1.21714437613667,"H1FX","H1 histone family member X",TRUE
+"1558168_at",0.919485127002411,0.658101765471238,0.448564765702156,-5.84215368874547,0.209345274739495,"H1FX-AS1","H1FX antisense RNA 1",TRUE
+"214412_at",0.933314818367461,0.705003587441104,0.383500820445085,-5.86830247915003,0.420724439064404,"H2AFB1///H2AFB2///H2AFB3","H2A histone family member B1///H2A histone family member B2///H2A histone family member B3",TRUE
+"224301_x_at",0.82847108093969,0.398449927280798,-0.86101858602031,-5.58490803375883,-0.900895236646129,"H2AFJ","H2A histone family member J",TRUE
+"225245_x_at",0.843475287501313,0.438738238393602,-0.788537870934513,-5.64128623096385,-0.656878133732585,"H2AFJ","H2A histone family member J",TRUE
+"228213_at",0.872668627020452,0.516118060720905,-0.659902604996287,-5.72977846932178,-0.47413658372864,"H2AFJ","H2A histone family member J",TRUE
+"220936_s_at",0.904832003218088,0.610155187745506,-0.517180086163241,-5.81023919801047,-0.359262658611225,"H2AFJ","H2A histone family member J",TRUE
+"212205_at",0.957571530817866,0.809582914066443,0.24386020834297,-5.91076034340142,0.0965073260141764,"H2AFV","H2A histone family member V",TRUE
+"227085_at",0.959357995170594,0.816106810882634,0.235339442000202,-5.91274360401685,0.0828946814202176,"H2AFV","H2A histone family member V",TRUE
+"202487_s_at",0.971216837324271,0.862764437282842,0.17487704462852,-5.92479909339882,0.0535652302363765,"H2AFV","H2A histone family member V",TRUE
+"212206_s_at",0.990810941805126,0.9537129007693,0.0587055435648937,-5.93800503458886,0.0257144810306116,"H2AFV","H2A histone family member V",TRUE
+"212525_s_at",0.75536453281804,0.249405312130413,-1.18285221431177,-5.28026480240007,-0.553098937133687,"H2AFX","H2A histone family member X",TRUE
+"205436_s_at",0.766550448794594,0.26780904467208,-1.13669885902025,-5.32922009776336,-0.411432262504478,"H2AFX","H2A histone family member X",TRUE
+"212524_x_at",0.903006708266697,0.602749183300705,-0.527998021943627,-5.80480374740098,-0.309310961391843,"H2AFX","H2A histone family member X",TRUE
+"213344_s_at",0.990810941805126,0.955483110029666,-0.0564578575812719,-5.93813109129329,-0.0170557496558157,"H2AFX","H2A histone family member X",TRUE
+"207168_s_at",0.457056805045302,0.0226459421100635,-2.44995600471175,-3.37520804228471,-0.548258937524274,"H2AFY","H2A histone family member Y",TRUE
+"214501_s_at",0.523369751179323,0.0389003321529658,-2.19536466204819,-3.83069545226547,-0.706793635698853,"H2AFY","H2A histone family member Y",TRUE
+"1558780_a_at",0.557622954313023,0.0525649462059669,-2.04826690639295,-4.07990564765698,-0.900801340195946,"H2AFY","H2A histone family member Y",TRUE
+"214500_at",0.878278790222455,0.531057961767298,0.636365400412659,-5.74434366349995,0.302916250787169,"H2AFY","H2A histone family member Y",TRUE
+"226840_at",0.912241810302154,0.631858074960573,-0.485829430474704,-5.82537115588509,-0.211855561821485,"H2AFY","H2A histone family member Y",TRUE
+"229593_at",0.96200396340887,0.827405772265348,0.220623678222516,-5.9160035459678,0.0847215671123127,"H2AFY","H2A histone family member Y",TRUE
+"1558779_at",0.989077673338926,0.946945768424315,0.0673009286527538,-5.93747761048002,0.0597795319776768,"H2AFY","H2A histone family member Y",TRUE
+"218445_at",0.898275196327427,0.587422913435844,-0.55059118936875,-5.79309891757275,-0.632376154596971,"H2AFY2","H2A histone family member Y2",TRUE
+"213911_s_at",0.866847998914329,0.498388053879688,-0.688331775684599,-5.71151055991263,-0.131070206477265,"H2AFZ","H2A histone family member Z",TRUE
+"200853_at",0.895690630367785,0.576079249968478,-0.567501372619388,-5.78402675649932,-0.129584383858489,"H2AFZ","H2A histone family member Z",TRUE
+"234899_at",0.70190082585548,0.173381285162475,-1.40672439094593,-5.01923575197245,-0.743947670242457,"H2BFM","H2B histone family member M",TRUE
+"208579_x_at",0.848268984089208,0.448060596636971,-0.772362496673825,-5.65323230754361,-0.442867687720558,"H2BFS","H2B histone family member S",TRUE
+"233963_at",0.674771081813037,0.141112620931875,1.5261870246007,-4.86472024762332,1.16976323840414,"H2BFXP","H2B histone family member X, pseudogene",TRUE
+"230664_at",0.910159094731364,0.625876284479503,-0.49441986567794,-5.82131669079392,-0.465267658060013,"H2BFXP","H2B histone family member X, pseudogene",TRUE
+"213826_s_at",0.998347572104896,0.992335891318201,0.00971465326730682,-5.93963751452003,0.00325442047610203,"H3F3A","H3 histone, family 3A",TRUE
+"211940_x_at",0.925091998149497,0.675993188359884,-0.423527923218256,-5.85269173650218,-0.103454604280532,"H3F3AP4///H3F3B///H3F3A","H3 histone, family 3A, pseudogene 4///H3 histone, family 3B///H3 histone, family 3A",TRUE
+"200080_s_at",0.926263798296325,0.679751787125283,-0.4183035605049,-5.85481570877157,-0.0948917283925841,"H3F3AP4///H3F3B///H3F3A","H3 histone, family 3A, pseudogene 4///H3 histone, family 3B///H3 histone, family 3A",TRUE
+"208755_x_at",0.937113154905832,0.720439675985626,-0.36246419249763,-5.87589479139853,-0.0903523124907348,"H3F3AP4///H3F3B///H3F3A","H3 histone, family 3A, pseudogene 4///H3 histone, family 3B///H3 histone, family 3A",TRUE
+"213828_x_at",0.967098323798013,0.846202544535933,-0.196251025766867,-5.9209418963009,-0.0465447074381782,"H3F3AP4///H3F3B///H3F3A","H3 histone, family 3A, pseudogene 4///H3 histone, family 3B///H3 histone, family 3A",TRUE
+"1555685_at",0.792305111661886,0.323356312421551,1.01009029396449,-5.45459635216925,0.493530585265969,"H6PD","hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase",TRUE
+"221892_at",0.83030603167465,0.402148452777086,-0.854176463223108,-5.59042790846243,-0.294578127624571,"H6PD","hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase",TRUE
+"226160_at",0.987380753616819,0.940752182865313,-0.0751723537475009,-5.93693151885727,-0.0300819787681004,"H6PD","hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase",TRUE
+"206933_s_at",0.992583835836326,0.965373847042994,-0.0439044510886037,-5.93874466106829,-0.026115987871357,"H6PD","hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase",TRUE
+"205657_at",0.650490742096872,0.120625067460151,1.61425283382782,-4.74442261706523,1.18551868658962,"HAAO","3-hydroxyanthranilate 3,4-dioxygenase",TRUE
+"216875_x_at",0.606900628956089,0.0803023865073057,1.8328205775384,-4.42390134607124,1.16527403708738,"HAB1","B1 for mucin",TRUE
+"215778_x_at",0.730623340800826,0.21326050106704,1.28152037755263,-5.16995266752306,0.393522600079946,"HAB1","B1 for mucin",TRUE
+"216878_x_at",0.910888708415045,0.628324565710285,0.49089937062269,-5.82298667072727,0.250133021062982,"HAB1","B1 for mucin",TRUE
+"206010_at",0.92247975200053,0.668649184927657,0.43377076399598,-5.84845232032333,0.168281531474023,"HABP2","hyaluronan binding protein 2",TRUE
+"209818_s_at",0.821187434813103,0.382451863390125,0.891097147808498,-5.56015711665421,0.543707381119111,"HABP4","hyaluronan binding protein 4",TRUE
+"209819_at",0.919372089675945,0.657022878082204,0.450083725076479,-5.84149525342194,0.329467192285917,"HABP4","hyaluronan binding protein 4",TRUE
+"233919_s_at",0.920780424288498,0.662968378935383,0.441726328466222,-5.84509095531226,0.222840265029641,"HABP4","hyaluronan binding protein 4",TRUE
+"232341_x_at",0.986889306520757,0.939579474830831,0.0766632804714295,-5.93682129017373,0.0357252505632051,"HABP4","hyaluronan binding protein 4",TRUE
+"1554376_s_at",0.752155597823425,0.245321472944223,1.19343530553558,-5.26879922837332,0.486565176458015,"HACD1","3-hydroxyacyl-CoA dehydratase 1",TRUE
+"219654_at",0.895213601869362,0.573459505305131,0.571430367375403,-5.78188079296368,0.706828123831407,"HACD1","3-hydroxyacyl-CoA dehydratase 1",TRUE
+"212640_at",0.987487323337591,0.941070452354919,0.0747677509129016,-5.9369610591196,0.0358478427507034,"HACD2","3-hydroxyacyl-CoA dehydratase 2",TRUE
+"227741_at",0.997901456792957,0.99032780650741,0.0122601238468799,-5.93961027024501,0.00583199761812203,"HACD2","3-hydroxyacyl-CoA dehydratase 2",TRUE
+"217777_s_at",0.636147339487472,0.107345841536695,-1.67826645119765,-4.65371170144137,-0.574682551315359,"HACD3","3-hydroxyacyl-CoA dehydratase 3",TRUE
+"222405_at",0.664654238054113,0.132432432910133,-1.5621128208573,-4.81628590872408,-0.524011163516239,"HACD3","3-hydroxyacyl-CoA dehydratase 3",TRUE
+"234000_s_at",0.683017520100356,0.151544317079788,-1.48533821569856,-4.91869907130241,-0.458169231992361,"HACD3","3-hydroxyacyl-CoA dehydratase 3",TRUE
+"222404_x_at",0.765205112543798,0.26510315942944,-1.14333462692324,-5.32228687428901,-0.336854758830418,"HACD3","3-hydroxyacyl-CoA dehydratase 3",TRUE
+"236939_at",0.380084968057051,0.0118053548145536,2.74377343806047,-2.817235429198,2.07717332587134,"HACD4","3-hydroxyacyl-CoA dehydratase 4",TRUE
+"244050_at",0.586160254590095,0.0659669799969119,1.93415383555313,-4.26537769085922,2.63467916994503,"HACD4","3-hydroxyacyl-CoA dehydratase 4",TRUE
+"227471_at",0.739189560382301,0.225964069946699,1.24548581220227,-5.21112149556896,0.473571927527647,"HACE1","HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1",TRUE
+"223211_at",0.99679212827105,0.983775034908718,0.0205671578245465,-5.93947745125795,0.00918799630947831,"HACL1","2-hydroxyacyl-CoA lyase 1",TRUE
+"211569_s_at",0.403035132901446,0.0149419700848876,-2.63884579261456,-3.0200316257701,-0.952191411772223,"HADH","hydroxyacyl-CoA dehydrogenase",TRUE
+"201036_s_at",0.423421354964585,0.0178266892351506,-2.55927927274553,-3.17127311333187,-0.952062404138971,"HADH","hydroxyacyl-CoA dehydrogenase",TRUE
+"201035_s_at",0.642592458809121,0.112874671198494,-1.65084660168369,-4.69289754659349,-0.457123168228835,"HADH","hydroxyacyl-CoA dehydrogenase",TRUE
+"208629_s_at",0.763513538570354,0.26337202263259,1.14760616885203,-5.31780505647498,0.343410916355559,"HADHA","hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit",TRUE
+"208631_s_at",0.819018525257656,0.373701556308558,0.907898012898975,-5.54598962149654,0.291443281914072,"HADHA","hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit",TRUE
+"208630_at",0.874161333445506,0.519986265491952,0.653772885299834,-5.7336205312259,0.179560749617178,"HADHA","hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit",TRUE
+"217156_at",0.606941574497969,0.0807904278610938,1.82965757819609,-4.42875209801358,0.65800311178945,"HADHAP1","hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit pseudogene 1",TRUE
+"201007_at",0.723655063748891,0.200611672007038,1.31908450691474,-5.12597384617441,0.38479569535906,"HADHB","hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit",TRUE
+"205012_s_at",0.784918343662568,0.309522565194278,-1.04007426082941,-5.42610331740545,-0.354951203144033,"HAGH","hydroxyacylglutathione hydrolase",TRUE
+"223485_at",0.642592458809121,0.112981179015043,-1.65032960693298,-4.69363165825752,-0.84926450983226,"HAGHL","hydroxyacylglutathione hydrolase-like",TRUE
+"228601_at",0.734602165123264,0.219178145764167,-1.26453533925165,-5.18948294139088,-1.31195778803289,"HAGLR","HOXD antisense growth-associated long non-coding RNA",TRUE
+"239182_at",0.873230718105642,0.517880326978991,-0.657106905454619,-5.73153505820126,-0.610589182241392,"HAGLR","HOXD antisense growth-associated long non-coding RNA",TRUE
+"242042_s_at",0.995126858395038,0.97766141568371,0.0283187983102354,-5.93929288590767,0.0163942578760476,"HAGLR","HOXD antisense growth-associated long non-coding RNA",TRUE
+"230935_at",0.989524702314661,0.948498401136671,0.065328391237411,-5.93760500712251,0.0986533744315068,"HAGLROS","HAGLR opposite strand (non-protein coding)",TRUE
+"217521_at",0.867447813467579,0.499976052034845,0.685762502006106,-5.7131917965771,0.487573512231569,"HAL","histidine ammonia-lyase",TRUE
+"206643_at",0.880814827834223,0.536439347383846,-0.627975778139168,-5.7494123592217,-0.490901449443485,"HAL","histidine ammonia-lyase",TRUE
+"237967_at",0.987492202135276,0.941125378401346,-0.0746979269983905,-5.93696614087819,-0.0677066841261826,"HAL","histidine ammonia-lyase",TRUE
+"220491_at",0.71454754703986,0.189526881469127,1.35355404976294,-5.08467661586226,0.466626780637062,"HAMP","hepcidin antimicrobial peptide",TRUE
+"220138_at",0.432151440378733,0.0193704870367803,2.52153412224221,-3.24220597262023,1.15036432651439,"HAND1","heart and neural crest derivatives expressed 1",TRUE
+"220480_at",0.789850877773366,0.318732575740732,1.0200102074508,-5.44525304929437,0.351345685470743,"HAND2","heart and neural crest derivatives expressed 2",TRUE
+"219791_s_at",0.883957552250683,0.54253248433244,-0.618530968945869,-5.75504105457196,-0.235886461840809,"HAND2-AS1","HAND2 antisense RNA 1 (head to head)",TRUE
+"236141_at",0.942502815705589,0.74221368341112,-0.333068502890021,-5.88579528501525,-0.25568543406626,"HAND2-AS1","HAND2 antisense RNA 1 (head to head)",TRUE
+"220224_at",0.879761308185056,0.534566624243693,0.6308901920918,-5.74765891615627,0.443948110097702,"HAO1","hydroxyacid oxidase 1",TRUE
+"231156_at",0.829803290928719,0.401428954486994,0.855504330475331,-5.58935986086708,0.384501638436313,"HAO2","hydroxyacid oxidase 2",TRUE
+"220801_s_at",0.901781358899845,0.598916966747443,-0.533620791280231,-5.80193533886823,-0.362033569549445,"HAO2","hydroxyacid oxidase 2",TRUE
+"238275_at",0.64513208805899,0.115873210502894,1.63644586780671,-4.7132801176192,0.806524972434559,"HAP1","huntingtin associated protein 1",TRUE
+"211222_s_at",0.687734660055697,0.156829621667193,1.4655106623946,-4.94447472873053,0.709980268631196,"HAP1","huntingtin associated protein 1",TRUE
+"211604_x_at",0.933314818367461,0.705032898091775,-0.383460710869704,-5.86831735693135,-0.229518854271392,"HAP1","huntingtin associated protein 1",TRUE
+"205523_at",0.768852835478002,0.272281575596704,-1.12583777316776,-5.34049118259686,-1.21859542581603,"HAPLN1","hyaluronan and proteoglycan link protein 1",TRUE
+"230895_at",0.925504446660705,0.677313566278314,-0.421691270988853,-5.85344138396715,-0.354645560783223,"HAPLN1","hyaluronan and proteoglycan link protein 1",TRUE
+"205524_s_at",0.966313390701604,0.842847668240322,0.200591754050522,-5.92010447733829,0.136965985575214,"HAPLN1","hyaluronan and proteoglycan link protein 1",TRUE
+"230204_at",0.97928472590149,0.899939071357898,0.127187710598737,-5.93180747009131,0.0529087620388351,"HAPLN1","hyaluronan and proteoglycan link protein 1",TRUE
+"220142_at",0.99783553534859,0.989241102831335,0.0136376750032453,-5.9395928941443,0.00864820494353769,"HAPLN2","hyaluronan and proteoglycan link protein 2",TRUE
+"227262_at",0.859483694145165,0.477036547856474,-0.72334334449115,-5.68800311658519,-0.34477146506934,"HAPLN3","hyaluronan and proteoglycan link protein 3",TRUE
+"235420_at",0.787929163003677,0.313903129620358,-1.03047958355327,-5.43530274541124,-0.609753455441629,"HAPLN4","hyaluronan and proteoglycan link protein 4",TRUE
+"1557098_s_at",0.861665593344139,0.483809588547968,-0.71214077351419,-5.69564557971518,-0.620137574201505,"HAR1A","highly accelerated region 1A (non-protein coding)",TRUE
+"241498_at",0.697412165374288,0.167919452709256,-1.42560448548787,-4.99549811701654,-0.594992134796715,"HARBI1","harbinger transposase derived 1",TRUE
+"209252_at",0.608709711882903,0.081400110959767,-1.82572942325384,-4.43476791876363,-0.621151141465822,"HARS2","histidyl-tRNA synthetase 2, mitochondrial",TRUE
+"207316_at",0.554475617948299,0.0508586232100726,2.06461137050795,-4.05276355932246,1.64692055621651,"HAS1","hyaluronan synthase 1",TRUE
+"206432_at",0.324623663332327,0.00741731881808352,2.94705453925999,-2.41466664863216,3.07621493851059,"HAS2","hyaluronan synthase 2",TRUE
+"230372_at",0.419258213999957,0.0172797343706398,2.57338914663722,-3.14462019001871,2.33167339999926,"HAS2","hyaluronan synthase 2",TRUE
+"1552980_at",0.867972140419125,0.501537178984382,0.683241212068608,-5.71483579356833,0.357273129355621,"HAS3","hyaluronan synthase 3",TRUE
+"223541_at",0.979415860312329,0.900957672965264,0.125885757408283,-5.93196782866473,0.100223326538597,"HAS3","hyaluronan synthase 3",TRUE
+"203138_at",0.842241409383444,0.435839710940755,-0.793610006070058,-5.63749225778156,-0.214896409523039,"HAT1","histone acetyltransferase 1",TRUE
+"225297_at",0.632216562924782,0.103126441440321,-1.70000808797472,-4.62229350763724,-0.690828341295482,"HAUS1","HAUS augmin like complex subunit 1",TRUE
+"229181_s_at",0.535243600695458,0.0427933145771456,2.14923240195736,-3.9100261009574,0.77619123385608,"HAUS2","HAUS augmin like complex subunit 2",TRUE
+"220071_x_at",0.675158868445887,0.141356640026287,1.52520366705382,-4.86603341697197,0.432365039827783,"HAUS2","HAUS augmin like complex subunit 2",TRUE
+"228744_at",0.789378278298554,0.315800803961767,1.02635237690255,-5.43923627933518,0.416186875874656,"HAUS2","HAUS augmin like complex subunit 2",TRUE
+"229208_at",0.819018525257656,0.374709743514763,0.905949132334861,-5.54764557168183,0.292834796812111,"HAUS2","HAUS augmin like complex subunit 2",TRUE
+"210054_at",0.535243600695458,0.0428277280205306,-2.14884181191898,-3.9106932890894,-0.692085552334374,"HAUS3","HAUS augmin like complex subunit 3",TRUE
+"213054_at",0.937409179150458,0.722143201929472,0.360152941847952,-5.87670317118938,0.13534426142581,"HAUS5","HAUS augmin like complex subunit 5",TRUE
+"213053_at",0.943464796017993,0.746521272979957,-0.327289217878598,-5.88764439049622,-0.0956539252206756,"HAUS5","HAUS augmin like complex subunit 5",TRUE
+"36888_at",0.961212424803935,0.823180238733252,0.226121003967591,-5.91481023775538,0.0742194881719378,"HAUS5","HAUS augmin like complex subunit 5",TRUE
+"222685_at",0.711902920992134,0.185559864673306,1.366275340919,-5.06921033738204,0.568355401428919,"HAUS6","HAUS augmin like complex subunit 6",TRUE
+"233655_s_at",0.895690630367785,0.575758672257089,0.56798167749865,-5.7837651904239,0.178275828332549,"HAUS6","HAUS augmin like complex subunit 6",TRUE
+"218602_s_at",0.942502815705589,0.742187123049704,-0.333104173350522,-5.88578377266913,-0.14808505815855,"HAUS6","HAUS augmin like complex subunit 6",TRUE
+"213334_x_at",0.942303845415102,0.740434851935764,-0.335458443037664,-5.88502125491043,-0.129604444185963,"HAUS7","HAUS augmin like complex subunit 7",TRUE
+"207891_s_at",0.838999550222784,0.424564135057903,-0.813542076642329,-5.62236160838051,-0.365076961318524,"HAUS7///TREX2","HAUS augmin like complex subunit 7///three prime repair exonuclease 2",TRUE
+"211788_s_at",0.951661984850334,0.778108776785538,-0.285241156824665,-5.90013231169216,-0.079881301778506,"HAUS7///TREX2","HAUS augmin like complex subunit 7///three prime repair exonuclease 2",TRUE
+"226308_at",0.883875568487877,0.542176468947943,-0.619081254258204,-5.75471536290631,-0.285144186890774,"HAUS8","HAUS augmin like complex subunit 8",TRUE
+"207052_at",0.872668627020452,0.51643175262302,0.659404570674637,-5.73009191683756,0.429335392785196,"HAVCR1","hepatitis A virus cellular receptor 1",TRUE
+"239386_at",0.763502833200335,0.26329946666688,1.14778565043562,-5.31761641757041,0.905317089740695,"HAVCR1P1","hepatitis A virus cellular receptor 1 pseudogene 1",TRUE
+"1554285_at",0.8288884913487,0.399496134290572,0.859079020368862,-5.58647694061937,0.33308329307164,"HAVCR2","hepatitis A virus cellular receptor 2",TRUE
+"1555628_a_at",0.848364007856994,0.448293738965625,0.771960608850979,-5.65352614201743,0.548764994475356,"HAVCR2","hepatitis A virus cellular receptor 2",TRUE
+"1555629_at",0.89395381756398,0.57015205436257,0.576403777198222,-5.77914381402798,0.218383195653149,"HAVCR2","hepatitis A virus cellular receptor 2",TRUE
+"235458_at",0.93613089056626,0.71455102049296,0.370469209700211,-5.8730555096802,0.138721366724053,"HAVCR2","hepatitis A virus cellular receptor 2",TRUE
+"201145_at",0.51470556386048,0.0352668641628207,-2.24237035407796,-3.74880408176792,-0.734511019723914,"HAX1","HCLS1 associated protein X-1",TRUE
+"244865_at",0.848268984089208,0.448092454843338,-0.772307572408993,-5.65327247314235,-0.502727071065426,"HAX1","HCLS1 associated protein X-1",TRUE
+"214414_x_at",0.704136697708699,0.175993955525938,-1.39786074184638,-5.03028994461347,-0.946891738647728,"HBA2///HBA1","hemoglobin subunit alpha 2///hemoglobin subunit alpha 1",TRUE
+"211699_x_at",0.839466826665106,0.425793649263905,-0.811352774843244,-5.62404075639602,-0.828351727223083,"HBA2///HBA1","hemoglobin subunit alpha 2///hemoglobin subunit alpha 1",TRUE
+"217414_x_at",0.839519981963042,0.426973005834883,-0.809256487389108,-5.6256445853487,-0.846391302907224,"HBA2///HBA1","hemoglobin subunit alpha 2///hemoglobin subunit alpha 1",TRUE
+"209458_x_at",0.894563570028521,0.571260851349718,-0.574734850319085,-5.78006482310189,-0.565321992479803,"HBA2///HBA1","hemoglobin subunit alpha 2///hemoglobin subunit alpha 1",TRUE
+"211745_x_at",0.93523910610914,0.712059628398366,-0.373863405957604,-5.87183315185813,-0.293986157718005,"HBA2///HBA1","hemoglobin subunit alpha 2///hemoglobin subunit alpha 1",TRUE
+"204018_x_at",0.998870448604467,0.996203570895235,-0.00481211011247885,-5.9396722021249,-0.00513610789883678,"HBA2///HBA1","hemoglobin subunit alpha 2///hemoglobin subunit alpha 1",TRUE
+"217232_x_at",0.819193107051406,0.375777332678235,0.903889197702765,-5.54939231078353,0.249875648961408,"HBB","hemoglobin subunit beta",TRUE
+"211696_x_at",0.82706053436911,0.395602023771125,0.866314996456339,-5.58060702073433,0.2550906374008,"HBB","hemoglobin subunit beta",TRUE
+"209116_x_at",0.898736771120062,0.588522590149275,0.54896055854175,-5.79395965331774,0.359846562501609,"HBB","hemoglobin subunit beta",TRUE
+"1562981_at",0.91171243420789,0.630853311585787,0.487269763103442,-5.8246962013878,0.139662392770135,"HBB","hemoglobin subunit beta",TRUE
+"216063_at",0.668587404382295,0.134887636208018,1.55175874138756,-4.8303363861711,0.807495752899365,"HBBP1","hemoglobin subunit beta pseudogene 1",TRUE
+"206834_at",0.656693876264681,0.124767910606788,1.59549311760331,-4.77049044472807,0.985816241637504,"HBD","hemoglobin subunit delta",TRUE
+"205919_at",0.870808709484996,0.510462689617408,0.668910396948358,-5.72407009928362,0.455733255744839,"HBE1","hemoglobin subunit epsilon 1",TRUE
+"217683_at",0.874951440969974,0.521754307844262,0.650979550026969,-5.73535996165456,0.47068556663762,"HBE1","hemoglobin subunit epsilon 1",TRUE
+"203821_at",0.438309018314998,0.0200976810044024,2.50471857757465,-3.27363199374408,3.1511085871188,"HBEGF","heparin binding EGF like growth factor",TRUE
+"38037_at",0.513365264670114,0.0344966386771402,2.25289881931581,-3.73031864514041,2.20269637736097,"HBEGF","heparin binding EGF like growth factor",TRUE
+"222076_at",0.921294973929502,0.664393955684798,0.439727205955803,-5.84594126041155,0.171727167260776,"HBEGF","heparin binding EGF like growth factor",TRUE
+"244857_at",0.940589433676148,0.73408123867206,0.344011212027822,-5.88220642895302,0.231617955858301,"HBEGF","heparin binding EGF like growth factor",TRUE
+"213515_x_at",0.615821255316333,0.0867340357553657,-1.79240863154616,-4.48542191479019,-1.03214357308854,"HBG2///HBG1","hemoglobin subunit gamma 2///hemoglobin subunit gamma 1",TRUE
+"204419_x_at",0.861981304384929,0.484725322923051,0.710633167718159,-5.69666540941329,0.400075710066435,"HBG2///HBG1","hemoglobin subunit gamma 2///hemoglobin subunit gamma 1",TRUE
+"204848_x_at",0.887083096014278,0.55136674005298,0.604936906377523,-5.76299814564593,0.308394322759466,"HBG2///HBG1","hemoglobin subunit gamma 2///hemoglobin subunit gamma 1",TRUE
+"240336_at",0.28785267911226,0.00492258353854528,3.12305156810494,-2.05728304719968,1.95674989473721,"HBM","hemoglobin subunit mu",TRUE
+"236645_at",0.727318639756418,0.207740641260642,1.29769458736989,-5.1511485482134,0.984954397713195,"HBP1","HMG-box transcription factor 1",TRUE
+"207361_at",0.937842878751575,0.724901082410015,0.356415427818192,-5.87799959164376,0.137383015323649,"HBP1","HMG-box transcription factor 1",TRUE
+"209102_s_at",0.983591056322836,0.92014111291816,-0.101404912964304,-5.93467627260832,-0.0457947789568696,"HBP1","HMG-box transcription factor 1",TRUE
+"220807_at",0.491581666454407,0.0294800483900017,2.32725315257535,-3.59832221029254,1.23046472379522,"HBQ1","hemoglobin subunit theta 1",TRUE
+"209315_at",0.600087813329005,0.0764666080560252,1.85827905249484,-4.3846407879578,1.71540691041719,"HBS1L","HBS1 like translational GTPase",TRUE
+"209314_s_at",0.728262401376535,0.208567682972513,1.29525018788055,-5.15400325748776,0.53174009959824,"HBS1L","HBS1 like translational GTPase",TRUE
+"209316_s_at",0.737123149977386,0.222816550886618,1.25426634948837,-5.20118259254114,0.403691752511515,"HBS1L","HBS1 like translational GTPase",TRUE
+"240602_at",0.965992617204023,0.8406681851875,-0.203413801178211,-5.91955025580651,-0.196732669043979,"HBS1L","HBS1 like translational GTPase",TRUE
+"206647_at",0.769258076576208,0.276177711918702,1.11648227605371,-5.35012312278926,0.632798432174165,"HBZ","hemoglobin subunit zeta",TRUE
+"224131_at",0.78638420006208,0.311779698952094,1.03511863490338,-5.4308643917512,0.678667199385484,"HCAR1","hydroxycarboxylic acid receptor 1",TRUE
+"205220_at",0.953553103224247,0.785764598178401,0.275131487332747,-5.90288120598269,0.308737625346215,"HCAR3","hydroxycarboxylic acid receptor 3",TRUE
+"1570315_at",0.557502997422893,0.0522375465166435,2.05136585823964,-4.07477028650016,0.565901812214677,"HCCAT5","hepatocellular carcinoma associated transcript 5 (non-protein coding)",TRUE
+"203745_at",0.402463840838386,0.0146616816044268,-2.64733084351152,-3.00377039104941,-0.776856572174221,"HCCS","holocytochrome c synthase",TRUE
+"203746_s_at",0.497725944448536,0.0305995764990858,-2.30970622147687,-3.62969736467848,-0.683058059047687,"HCCS","holocytochrome c synthase",TRUE
+"202474_s_at",0.812302873476553,0.357084465359224,-0.940536124410504,-5.51777039315355,-0.269974494644089,"HCFC1","host cell factor C1",TRUE
+"202473_x_at",0.928887766306469,0.686909742428956,0.408386676958056,-5.85877611060324,0.182781907843112,"HCFC1","host cell factor C1",TRUE
+"231177_at",0.993615552413264,0.970050492014441,-0.0379714571118115,-5.93898124215888,-0.0276824311587047,"HCFC1","host cell factor C1",TRUE
+"218537_at",0.906845308365483,0.614946167195927,0.510215139711245,-5.81368069367056,0.271066290285313,"HCFC1R1","host cell factor C1 regulator 1",TRUE
+"45714_at",0.958933497686198,0.814286417681361,0.237715212263582,-5.91219768113482,0.0925359486599024,"HCFC1R1","host cell factor C1 regulator 1",TRUE
+"235264_at",0.565210521362331,0.0564745327517589,-2.01253370533024,-4.13874958967148,-1.14326359731511,"HCFC2","host cell factor C2",TRUE
+"219484_at",0.733985531576126,0.218210051260883,-1.26728967584353,-5.18633098733993,-0.608309527420491,"HCFC2","host cell factor C2",TRUE
+"1557167_at",0.822241803732333,0.386991609403251,0.882479943295835,-5.56732859315146,1.12838818358906,"HCG11","HLA complex group 11 (non-protein coding)",TRUE
+"1557169_x_at",0.838350545718411,0.423399608942341,0.815619314252565,-5.62076448782004,0.861167788337978,"HCG11","HLA complex group 11 (non-protein coding)",TRUE
+"241846_at",0.405526773546471,0.0151604339301141,2.63233554737256,-3.03249123970658,0.909876584249663,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"242972_at",0.651636743353835,0.121042342795261,1.61233915881141,-4.74709260950517,0.758451478005607,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"235788_at",0.673582826047901,0.139857914008437,1.53126546363197,-4.85792782179405,0.624391059929783,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"225584_at",0.813418501361393,0.363392119002988,0.928029989592634,-5.52869169197742,0.314315908320904,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"216527_at",0.848256601067529,0.44788879407807,0.772658729037241,-5.6530156291152,0.550005108615665,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"242812_at",0.860085676417428,0.479432403682458,0.719370080522031,-5.69072668785296,0.284392995773036,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"232975_at",0.91994485246627,0.659098762530725,-0.447162051662744,-5.84275979538185,-0.173770651595679,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"242618_at",0.94312295509926,0.744545333533596,0.329938816994976,-5.8868006164139,0.186793838627782,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"225577_at",0.977876240373041,0.89326110560935,0.135729020361436,-5.93071460649244,0.053109492061342,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"1558967_s_at",0.988303954498837,0.944361258323497,0.0705850223876804,-5.93725710404032,0.0287768425384272,"HCG18","HLA complex group 18 (non-protein coding)",TRUE
+"1560767_at",0.993685841752871,0.970295376671281,-0.0376608262323623,-5.9389926842963,-0.0167509244801289,"HCG22","HLA complex group 22",TRUE
+"214186_s_at",0.74552004660471,0.237195212934662,1.21489392220003,-5.24527887772856,0.522399975404771,"HCG26","HLA complex group 26 (non-protein coding)",TRUE
+"1559050_at",0.922220473850152,0.668112708735934,0.434520837361412,-5.84813796207391,0.301843984256876,"HCG27","HLA complex group 27 (non-protein coding)",TRUE
+"206685_at",0.661221664662217,0.128966947086564,1.57700132171376,-4.79595355210332,1.73586456354765,"HCG4","HLA complex group 4 (non-protein coding)",TRUE
+"215973_at",0.741260241503758,0.231832371751752,1.22936108010615,-5.22921692843628,0.426317916229238,"HCG4B","HLA complex group 4B (non-protein coding)",TRUE
+"215974_at",0.958587459575795,0.812268743257384,0.240350087484632,-5.91158584105325,0.20085595977959,"HCG4B","HLA complex group 4B (non-protein coding)",TRUE
+"215985_at",0.615821255316333,0.0863557815278951,1.79471236789887,-4.48194154664562,0.610686941184454,"HCG8///ZNRD1ASP","HLA complex group 8///zinc ribbon domain containing 1 antisense, pseudogene",TRUE
+"234457_at",0.815977292327875,0.366899429473889,-0.921138844118852,-5.53465209023687,-0.756235034107462,"HCG8///ZNRD1ASP","HLA complex group 8///zinc ribbon domain containing 1 antisense, pseudogene",TRUE
+"234097_s_at",0.877333806479767,0.526919323411662,0.642848958457739,-5.7403822355115,0.542651138865886,"HCG8///ZNRD1ASP","HLA complex group 8///zinc ribbon domain containing 1 antisense, pseudogene",TRUE
+"208287_at",0.812302873476553,0.358741034433463,0.937237390779702,-5.52066413526963,0.472152109110839,"HCG9","HLA complex group 9 (non-protein coding)",TRUE
+"208018_s_at",0.907964244160782,0.617986296264581,0.505808758142592,-5.81583445880462,0.220025300173045,"HCK","HCK proto-oncogene, Src family tyrosine kinase",TRUE
+"202957_at",0.396220771188728,0.0136620027882795,2.67889111491739,-2.94306937366348,1.93272792802739,"HCLS1","hematopoietic cell-specific Lyn substrate 1",TRUE
+"1562563_at",0.823741997583852,0.390891378643128,-0.8751300096138,-5.57339433268961,-0.399275033167854,"HCN1","hyperpolarization activated cyclic nucleotide gated potassium channel 1",TRUE
+"1556351_at",0.998347572104896,0.992772356743696,0.00916139415092022,-5.93964260106663,0.00729587934525777,"HCN1","hyperpolarization activated cyclic nucleotide gated potassium channel 1",TRUE
+"207592_s_at",0.580630437263151,0.0629871377799329,-1.95762067134638,-4.22782384746496,-1.75214524248724,"HCN2","hyperpolarization activated cyclic nucleotide gated potassium channel 2",TRUE
+"214893_x_at",0.955515814503015,0.796193719042817,0.261406371246815,-5.90645555114627,0.14425457407766,"HCN2","hyperpolarization activated cyclic nucleotide gated potassium channel 2",TRUE
+"228741_s_at",0.749589620061359,0.242523815288342,-1.20076176273298,-5.26080978128478,-0.519396179433659,"HCN3","hyperpolarization activated cyclic nucleotide gated potassium channel 3",TRUE
+"230208_at",0.809930331505913,0.353448105423784,0.947813546030663,-5.5113534495511,0.229294256082519,"HCN4","hyperpolarization activated cyclic nucleotide gated potassium channel 4",TRUE
+"206946_at",0.899825513763341,0.5937072423354,-0.541292752827069,-5.79797388066565,-0.366503180214803,"HCN4","hyperpolarization activated cyclic nucleotide gated potassium channel 4",TRUE
+"206082_at",0.39657361496013,0.0137232241335998,2.67689671957736,-2.94691528822891,2.95506642241501,"HCP5","HLA complex P5 (non-protein coding)",TRUE
+"1560213_at",0.930374550176682,0.692195262040916,0.401090634941233,-5.8616301490064,0.132021408594786,"HCP5B","HLA complex P5B (non-protein coding)",TRUE
+"216176_at",0.987785501041707,0.94187854250221,0.0737405166361713,-5.93703534221326,0.0444199299455157,"HCRP1","hepatocellular carcinoma-related HCRP1",TRUE
+"216174_at",0.994943851647199,0.976132080786986,0.0302581467956646,-5.93923755728563,0.0200601465460242,"HCRP1","hepatocellular carcinoma-related HCRP1",TRUE
+"207642_at",0.830635993561085,0.403429516299189,-0.851815965632796,-5.59232271776311,-0.389360786538343,"HCRT","hypocretin neuropeptide precursor",TRUE
+"207619_at",0.857287594027564,0.47230871250152,0.731218371161398,-5.68256285884441,0.498094977157787,"HCRTR1","hypocretin receptor 1",TRUE
+"207393_at",0.941158863404109,0.736269366083828,0.341062793448406,-5.88318470603089,0.199054146688388,"HCRTR2","hypocretin receptor 2",TRUE
+"223640_at",0.867972140419125,0.501343847727121,-0.683553209308163,-5.71463267080477,-0.362806169095329,"HCST","hematopoietic cell signal transducer",TRUE
+"201209_at",0.961212424803935,0.822916116529281,-0.226464856055097,-5.91473462638007,-0.0758070973002152,"HDAC1","histone deacetylase 1",TRUE
+"232870_at",0.822010986888098,0.38583701206081,0.884665274459997,-5.56551601270488,0.663748425332031,"HDAC10","histone deacetylase 10",TRUE
+"226672_s_at",0.993063971571452,0.966945526374931,0.0419103814017978,-5.9388280002802,0.0168200316489893,"HDAC10","histone deacetylase 10",TRUE
+"219847_at",0.622434989367596,0.092647288809954,-1.75747463798432,-4.53779767478339,-1.55985399182246,"HDAC11","histone deacetylase 11",TRUE
+"227679_at",0.672364894096,0.138199116229554,-1.5380372897599,-4.84884261785989,-1.3345908356823,"HDAC11","histone deacetylase 11",TRUE
+"242141_at",0.387357699611418,0.0127728939561438,2.70884748500547,-2.88514283360416,0.781603217175734,"HDAC2","histone deacetylase 2",TRUE
+"201833_at",0.907964244160782,0.618045449163732,0.50572312240726,-5.81587613558591,0.207462884733035,"HDAC2","histone deacetylase 2",TRUE
+"216326_s_at",0.966593471043185,0.844194471287777,-0.198848715284787,-5.92044293947495,-0.0585759050723684,"HDAC3","histone deacetylase 3",TRUE
+"204225_at",0.871744769522775,0.513768257915079,-0.66363863307741,-5.72741989437596,-0.26354227161107,"HDAC4","histone deacetylase 4",TRUE
+"1554322_a_at",0.907964244160782,0.618118875251578,-0.505616828686541,-5.81592785651855,-0.341084385775427,"HDAC4","histone deacetylase 4",TRUE
+"228813_at",0.99925604280637,0.99756943199032,0.00308082483188766,-5.9396788577994,0.00131318373528444,"HDAC4","histone deacetylase 4",TRUE
+"202455_at",0.690381347688918,0.160096107533021,-1.4535259076616,-4.95991870540542,-0.695387038876881,"HDAC5","histone deacetylase 5",TRUE
+"229408_at",0.789661545166663,0.317358554560247,1.02297745253499,-5.44244223953647,0.609368331406592,"HDAC5","histone deacetylase 5",TRUE
+"211722_s_at",0.480603497646452,0.027124624281248,2.3662652525423,-3.52808025854477,0.857163489881272,"HDAC6","histone deacetylase 6",TRUE
+"216224_s_at",0.80764044633141,0.349099695705782,0.95658273678144,-5.50356092482484,0.630227496058512,"HDAC6","histone deacetylase 6",TRUE
+"206846_s_at",0.979606049979413,0.903027617970068,0.123240685185403,-5.93228854264904,0.0359879270739061,"HDAC6","histone deacetylase 6",TRUE
+"236326_at",0.631316839203356,0.102613059570181,1.70270470524491,-4.6183754845819,0.991579635405476,"HDAC7","histone deacetylase 7",TRUE
+"217937_s_at",0.700061364939874,0.171830429160825,1.41203632494805,-5.01258345027713,0.573306619316324,"HDAC7","histone deacetylase 7",TRUE
+"223345_at",0.655235030401569,0.123946324771608,-1.59917168150664,-4.76539749945684,-0.422956516126165,"HDAC8","histone deacetylase 8",TRUE
+"223908_at",0.778481681746654,0.298410176629279,-1.06485230995776,-5.40199163051554,-0.449415605490191,"HDAC8","histone deacetylase 8",TRUE
+"223909_s_at",0.822356669023087,0.387137880346624,-0.88220339677432,-5.56755767297881,-0.271115317016118,"HDAC8","histone deacetylase 8",TRUE
+"205659_at",0.557589172116298,0.0524077642278707,2.04975253026789,-4.0774444134293,2.84199610553982,"HDAC9","histone deacetylase 9",TRUE
+"1552758_at",0.622434989367596,0.0930457511265721,1.75519020826656,-4.54119629850605,1.15721692537987,"HDAC9","histone deacetylase 9",TRUE
+"230968_at",0.647518308302168,0.11860634714928,1.62358990371437,-4.73136027707772,2.12727395291917,"HDAC9","histone deacetylase 9",TRUE
+"234393_at",0.973615804712521,0.873059425569364,0.161633375547529,-5.92696679218958,0.0597206193095934,"HDAC9","histone deacetylase 9",TRUE
+"1552760_at",0.978240571220736,0.894483261595646,-0.134165093726609,-5.93092001289765,-0.132567476440188,"HDAC9","histone deacetylase 9",TRUE
+"207067_s_at",0.863255498935676,0.487433447885545,0.706184306865242,-5.69966286844082,0.321096050626761,"HDC","histidine decarboxylase",TRUE
+"203259_s_at",0.960031906173606,0.819211335601608,-0.231290953662505,-5.91366132976134,-0.100216265812046,"HDDC2","HD domain containing 2",TRUE
+"203260_at",0.997056683282451,0.98510437439621,-0.0188818363127954,-5.93950983267093,-0.0103703381897935,"HDDC2","HD domain containing 2",TRUE
+"227008_at",0.812055457762952,0.356235027973377,-0.942231608670648,-5.51627943594617,-0.441121912619609,"HDDC3","HD domain containing 3",TRUE
+"200896_x_at",0.962177189402189,0.828097116131859,-0.219724921188755,-5.91619585977752,-0.0516873956014958,"HDGF","hepatoma-derived growth factor",TRUE
+"232680_at",0.930520419444084,0.692559075051451,0.40058925211373,-5.86182441814524,0.100927118430505,"HDGFL1","hepatoma derived growth factor-like 1",TRUE
+"223252_at",0.835952408568777,0.416337074784907,-0.828294591896022,-5.61093620861721,-0.212572175815001,"HDGFRP2","hepatoma-derived growth factor-related protein 2",TRUE
+"1558102_at",0.812302873476553,0.3573027732102,0.940100818816996,-5.51815279003451,0.606287444744462,"HDGFRP3","hepatoma-derived growth factor, related protein 3",TRUE
+"1558103_a_at",0.859619953488811,0.477676697336938,0.722280587388971,-5.68873300694687,0.670150132280859,"HDGFRP3","hepatoma-derived growth factor, related protein 3",TRUE
+"221976_s_at",0.904381089098038,0.607102835477497,0.521631009425697,-5.80801610988772,0.333783350950196,"HDGFRP3","hepatoma-derived growth factor, related protein 3",TRUE
+"209526_s_at",0.940044918888428,0.731113905085204,0.348014559547654,-5.88086480462813,0.317077017368266,"HDGFRP3","hepatoma-derived growth factor, related protein 3",TRUE
+"209524_at",0.94630837494651,0.756922364909893,0.313380886194398,-5.89196306453279,0.456091740744524,"HDGFRP3","hepatoma-derived growth factor, related protein 3",TRUE
+"228266_s_at",0.957571530817866,0.808870580482843,0.244791683785604,-5.91053928437635,0.258337847942062,"HDGFRP3","hepatoma-derived growth factor, related protein 3",TRUE
+"216693_x_at",0.958473780774099,0.811802402686735,0.240959327155072,-5.91144341581091,0.216193971955898,"HDGFRP3","hepatoma-derived growth factor, related protein 3",TRUE
+"209525_at",0.988654915812939,0.945257169165457,0.0694465152729616,-5.9373347366616,0.0411829345444028,"HDGFRP3","hepatoma-derived growth factor, related protein 3",TRUE
+"223155_at",0.194385040981272,0.00208695050856894,-3.48401819122598,-1.30466305441467,-1.29544301781853,"HDHD2","haloacid dehalogenase like hydrolase domain containing 2",TRUE
+"221256_s_at",0.785175995766517,0.310564829796884,-1.03778277120519,-5.42830739180108,-0.431320986259175,"HDHD3","haloacid dehalogenase like hydrolase domain containing 3",TRUE
+"200643_at",0.592488489935347,0.069465619240742,-1.90776400287298,-4.30723582951775,-0.573745161120289,"HDLBP","high density lipoprotein binding protein",TRUE
+"222916_s_at",0.782311754252508,0.304492627631144,1.05121027703355,-5.41532986142786,0.429623355914804,"HDLBP","high density lipoprotein binding protein",TRUE
+"235624_at",0.85334340854827,0.461053211735472,0.75015562007984,-5.66925179775083,0.229202395418755,"HDLBP","high density lipoprotein binding protein",TRUE
+"225012_at",0.866379815542966,0.497342421410727,0.690026079523467,-5.71039858484645,0.297886929266687,"HDLBP","high density lipoprotein binding protein",TRUE
+"219674_s_at",0.867159108376357,0.499124016298028,-0.687140461145344,-5.71229085848576,-0.237578084817611,"HDLBP","high density lipoprotein binding protein",TRUE
+"221767_x_at",0.899331416659389,0.589874856069778,-0.546957442187522,-5.79501361293139,-0.17794520742973,"HDLBP","high density lipoprotein binding protein",TRUE
+"1553646_at",0.980439435497171,0.908710898835284,-0.115982893520764,-5.93313361534415,-0.10123244557388,"HDX","highly divergent homeobox",TRUE
+"218594_at",0.785175995766517,0.310672180264162,1.03754706230284,-5.42853386059119,0.440235123146694,"HEATR1","HEAT repeat containing 1",TRUE
+"228351_at",0.792716268502624,0.324421295629952,1.00781947983736,-5.4567235421889,0.308234472547685,"HEATR1","HEAT repeat containing 1",TRUE
+"218595_s_at",0.812302873476553,0.358024153884591,0.938663658163057,-5.51941411876885,0.335142367418694,"HEATR1","HEAT repeat containing 1",TRUE
+"1556348_at",0.899808883319249,0.592064368412249,0.543718897293616,-5.79670968671639,0.294060001293185,"HEATR1","HEAT repeat containing 1",TRUE
+"232414_at",0.974982245454858,0.877738602408752,0.15562390671419,-5.92789427593437,0.161636844832888,"HEATR1","HEAT repeat containing 1",TRUE
+"219289_at",0.755940660414394,0.250522381674567,-1.17997996130057,-5.28336118992361,-0.37944839721064,"HEATR3","HEAT repeat containing 3",TRUE
+"1554478_a_at",0.953983577550391,0.787925781687483,-0.27228293928542,-5.90363796797096,-0.113287704515098,"HEATR3","HEAT repeat containing 3",TRUE
+"1560727_at",0.89547555116602,0.57461791617594,0.569691909221954,-5.78283208508228,0.300192186603515,"HEATR4","HEAT repeat containing 4",TRUE
+"226510_at",0.587626678796111,0.0665775068953395,-1.92946142908417,-4.27284957960985,-0.76758754298713,"HEATR5A","HEAT repeat containing 5A",TRUE
+"233642_s_at",0.76858139690485,0.271791542978484,1.1270213629949,-5.33926755398065,0.379227390591195,"HEATR5B","HEAT repeat containing 5B",TRUE
+"1569503_at",0.851319596585235,0.454787409982232,0.760817365226139,-5.66161582227999,0.69774616031126,"HEATR5B","HEAT repeat containing 5B",TRUE
+"65493_at",0.731548533938014,0.215195438536182,-1.27592717385556,-5.17640858193658,-0.989289200073354,"HEATR6","HEAT repeat containing 6",TRUE
+"240149_at",0.740321726337106,0.228898840841444,-1.23738242839943,-5.22024063118844,-0.480470813989441,"HEATR6","HEAT repeat containing 6",TRUE
+"1557121_s_at",0.790309297261437,0.319964831013959,-1.01735671526101,-5.4477603955795,-0.595467444820602,"HEATR6","HEAT repeat containing 6",TRUE
+"218991_at",0.832025856611965,0.408350833769099,-0.842792206715909,-5.5995211484928,-0.691616073787751,"HEATR6","HEAT repeat containing 6",TRUE
+"1553378_a_at",0.888284472488395,0.554107548581421,-0.600742749073385,-5.76541868766506,-0.232746420802716,"HEATR9","HEAT repeat containing 9",TRUE
+"218450_at",0.837153794522818,0.419641043374245,0.822348211914551,-5.61556464755177,0.36379876751915,"HEBP1","heme binding protein 1",TRUE
+"231280_at",0.94713024133591,0.759971644329158,0.309315443827948,-5.89319034631971,0.155898162396704,"HEBP2","heme binding protein 2",TRUE
+"203430_at",0.986361618040699,0.935606651174157,0.0817154888675912,-5.93643167838194,0.0284093296136056,"HEBP2","heme binding protein 2",TRUE
+"218603_at",0.268558783291603,0.00414565364605602,3.19602193422634,-1.90705612013989,0.979025169244375,"HECA","hdc homolog, cell cycle regulator",TRUE
+"230529_at",0.852094603401457,0.457712262240991,0.755829610656233,-5.66520076134464,0.493915619884563,"HECA","hdc homolog, cell cycle regulator",TRUE
+"230582_at",0.869493932916254,0.506843002029702,-0.67470505716096,-5.72035876617481,-0.270799485803745,"HECA","hdc homolog, cell cycle regulator",TRUE
+"242349_at",0.767727587789514,0.270133993402366,-1.1310365056406,-5.33510812332886,-0.430230550816341,"HECTD1","HECT domain E3 ubiquitin protein ligase 1",TRUE
+"224481_s_at",0.768803785780457,0.271904139106295,-1.12674926826362,-5.33954895380166,-0.30568245339046,"HECTD1","HECT domain E3 ubiquitin protein ligase 1",TRUE
+"1557100_s_at",0.775581183114088,0.292857947831491,-1.07747947433935,-5.3895084651978,-0.302977201502035,"HECTD1","HECT domain E3 ubiquitin protein ligase 1",TRUE
+"1570251_at",0.839425347843955,0.425324195908936,0.812188228182963,-5.62340048226743,0.475632798196515,"HECTD1","HECT domain E3 ubiquitin protein ligase 1",TRUE
+"241955_at",0.961428009227818,0.825183944929745,-0.223513348720791,-5.91537992699921,-0.0680327725574781,"HECTD1","HECT domain E3 ubiquitin protein ligase 1",TRUE
+"241683_at",0.975657122206595,0.883927616670121,-0.147684317919818,-5.92906589365063,-0.0592534308102941,"HECTD1","HECT domain E3 ubiquitin protein ligase 1",TRUE
+"238803_at",0.835952408568777,0.415763756146971,-0.829329457120995,-5.61012752002114,-0.573188721039523,"HECTD2","HECT domain E3 ubiquitin protein ligase 2",TRUE
+"227568_at",0.961212424803935,0.823669140280363,-0.225484592500222,-5.91494987987412,-0.134853553496061,"HECTD2","HECT domain E3 ubiquitin protein ligase 2",TRUE
+"1565698_at",0.973936963444057,0.873881562199477,-0.160577070182811,-5.92713235826199,-0.140606642215917,"HECTD2","HECT domain E3 ubiquitin protein ligase 2",TRUE
+"1565699_at",0.990712448117538,0.952967937740883,0.0596515366847546,-5.9379505097778,0.0538984306789771,"HECTD2","HECT domain E3 ubiquitin protein ligase 2",TRUE
+"218632_at",0.869210945057612,0.506180973169277,-0.675767389987146,-5.71967504565657,-0.24775827316221,"HECTD3","HECT domain E3 ubiquitin protein ligase 3",TRUE
+"244378_at",0.592605015502039,0.0697902824840902,1.90537468894912,-4.31100592623966,0.573094319684984,"HECTD4","HECT domain E3 ubiquitin protein ligase 4",TRUE
+"211034_s_at",0.683805950121197,0.152594721489323,-1.48135343260586,-4.92390170488888,-0.520086168308334,"HECTD4","HECT domain E3 ubiquitin protein ligase 4",TRUE
+"230216_at",0.765228531154075,0.265293220082771,1.14286690949089,-5.32277672232312,0.450309810437878,"HECTD4","HECT domain E3 ubiquitin protein ligase 4",TRUE
+"1553821_at",0.805746717966166,0.345981082719555,0.962917605718382,-5.49789075106722,0.588770700275872,"HECTD4","HECT domain E3 ubiquitin protein ligase 4",TRUE
+"1557529_at",0.848475456105025,0.448787395724326,-0.771110068022829,-5.654147526565,-0.543113922725935,"HECTD4","HECT domain E3 ubiquitin protein ligase 4",TRUE
+"1561130_at",0.854464019770416,0.466075476511202,0.741672216192187,-5.67525471576622,0.426821645390441,"HECTD4","HECT domain E3 ubiquitin protein ligase 4",TRUE
+"215584_at",0.540483367247649,0.0449041110767363,2.12578357243257,-3.94994490530621,0.733600947933007,"HECW1","HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1",TRUE
+"243163_at",0.597654932724127,0.0736753143850009,1.87751403780753,-4.35472316038392,1.14846861217647,"HECW1","HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1",TRUE
+"210331_at",0.817560991958296,0.370039673485972,0.915006057394361,-5.53992213875468,0.312708993517663,"HECW1","HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1",TRUE
+"1560950_at",0.895690630367785,0.575814879524376,0.567897455323428,-5.78381107193297,0.500116236404355,"HECW1-IT1","HECW1 intronic transcript 1",TRUE
+"232080_at",0.784498961298069,0.307611242642112,-1.04429063447495,-5.42203635707551,-0.785146890880158,"HECW2","HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2",TRUE
+"243080_at",0.823074246722209,0.389530055406199,0.877690267539304,-5.5712867511789,0.55418602098447,"HECW2","HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2",TRUE
+"236089_at",0.933599541599416,0.705993260809164,0.382146875441497,-5.86880384758906,0.346488350095274,"HECW2","HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2",TRUE
+"212822_at",0.660460734341314,0.128538065581143,1.57886689373698,-4.79339519173641,1.39449285405149,"HEG1","heart development protein with EGF like domains 1",TRUE
+"213069_at",0.675622576285316,0.142032892449343,1.52248574401047,-4.86965940926838,2.00439282738938,"HEG1","heart development protein with EGF like domains 1",TRUE
+"226146_at",0.825648186672984,0.393221206378607,-0.870761665460152,-5.57697711338958,-0.505777075326394,"HEIH","hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA",TRUE
+"1552787_at",0.681231910132377,0.149121131567516,-1.49461724350879,-4.90654055538384,-0.751973585038934,"HELB","DNA helicase B",TRUE
+"1570200_at",0.767965891104819,0.270648809311955,1.12978752102336,-5.33640339150673,0.53941094267335,"HELB","DNA helicase B",TRUE
+"1552788_a_at",0.925609356441173,0.678424679470024,-0.420146849224843,-5.8540692759355,-0.259284530395999,"HELB","DNA helicase B",TRUE
+"220085_at",0.778580821633075,0.298633111986032,1.06434881906194,-5.40248664876188,0.557388560019684,"HELLS","helicase, lymphoid-specific",TRUE
+"223556_at",0.812302873476553,0.35831150103349,0.938091737223325,-5.519915574239,0.406013482047699,"HELLS","helicase, lymphoid-specific",TRUE
+"234040_at",0.871744769522775,0.514155401397047,-0.663022448908411,-5.72780977368437,-0.29861894742047,"HELLS","helicase, lymphoid-specific",TRUE
+"227349_at",0.908619002315341,0.619759479746524,0.503243378076366,-5.81707997905552,0.180776881609106,"HELLS","helicase, lymphoid-specific",TRUE
+"227350_at",0.916912399329188,0.648542482023531,0.462061112393506,-5.83622689276098,0.182811873383949,"HELLS","helicase, lymphoid-specific",TRUE
+"228736_at",0.704396794850573,0.17626569504423,-1.39694488471491,-5.03142885662443,-0.419908030761689,"HELQ","helicase, POLQ-like",TRUE
+"243809_at",0.737488397392592,0.223709368171026,-1.25176610738524,-5.20401878163893,-0.956928105389639,"HELQ","helicase, POLQ-like",TRUE
+"241784_x_at",0.786851686785014,0.312676915151824,1.03315578509775,-5.43274451707143,0.643394502680195,"HELQ","helicase, POLQ-like",TRUE
+"1554342_s_at",0.914242258486146,0.639413396458216,-0.475031892610355,-5.83036876270866,-0.141191008081277,"HELQ","helicase, POLQ-like",TRUE
+"1554341_a_at",0.925375904025762,0.67659805851385,-0.422686362366471,-5.85303562523326,-0.163066602570953,"HELQ","helicase, POLQ-like",TRUE
+"240486_at",0.627861734840005,0.0992154326807421,-1.72084636984524,-4.59189584580061,-0.914452289699354,"HELZ","helicase with zinc finger",TRUE
+"203674_at",0.919485127002411,0.658199876327478,-0.448426689199311,-5.84221343361942,-0.156763470668146,"HELZ","helicase with zinc finger",TRUE
+"225910_at",0.988065316951061,0.942891082327051,-0.0724535030544396,-5.93712696134057,-0.027820090156391,"HELZ","helicase with zinc finger",TRUE
+"232517_s_at",0.594005743610726,0.0708600404001403,1.8975703184024,-4.32329748331823,0.751865386273774,"HELZ2","helicase with zinc finger 2",TRUE
+"228230_at",0.65349309458318,0.12287884537596,1.6039817022191,-4.75872430878985,1.09652623359943,"HELZ2","helicase with zinc finger 2",TRUE
+"232787_at",0.702630084418366,0.174255623473573,1.40374635032258,-5.02295620803281,0.967998359561644,"HELZ2","helicase with zinc finger 2",TRUE
+"232518_at",0.776955214137673,0.295625872278272,1.07116330430521,-5.39576906024327,0.417474483595791,"HELZ2","helicase with zinc finger 2",TRUE
+"223670_s_at",0.9534258874175,0.785410186909633,-0.275598840497774,-5.90275629956615,-0.121975151634488,"HEMGN","hemogen",TRUE
+"223669_at",0.953983577550391,0.78820747544355,0.271911822799811,-5.9037359852183,0.207032583857753,"HEMGN","hemogen",TRUE
+"218620_s_at",0.703181475205533,0.175001728969723,-1.40121449246707,-5.02611413510807,-0.634321597492463,"HEMK1","HemK methyltransferase family member 1",TRUE
+"218621_at",0.869082033398093,0.50600572409702,-0.676048736315152,-5.71949379794893,-0.462909304059255,"HEMK1","HemK methyltransferase family member 1",TRUE
+"1556092_s_at",0.962125056232529,0.827995351285338,-0.219857205327292,-5.9161676029842,-0.110697578429253,"HEMK1","HemK methyltransferase family member 1",TRUE
+"52159_at",0.973071267819624,0.870453203239199,-0.164983177572459,-5.92643458028982,-0.0660414362633119,"HEMK1","HemK methyltransferase family member 1",TRUE
+"225841_at",0.835952408568777,0.416288344700096,0.828382516856411,-5.6108675369638,0.984368684113116,"HENMT1","HEN1 methyltransferase homolog 1",TRUE
+"242601_at",0.912241810302154,0.631890055652733,-0.485783603141424,-5.82539259898093,-0.456165222213628,"HEPACAM2","HEPACAM family member 2",TRUE
+"203903_s_at",0.822469863206885,0.387456593151392,-0.881601059593717,-5.56805639400428,-0.616533697914107,"HEPH","hephaestin",TRUE
+"203902_at",0.937623890519979,0.723331458603813,0.35854196374065,-5.87726360430202,0.288530158479722,"HEPH","hephaestin",TRUE
+"238003_at",0.671498069723584,0.137612653668355,-1.54044746043489,-4.84560142031178,-0.951453918504692,"HEPN1///HEPACAM","hepatocellular carcinoma, down-regulated 1///hepatic and glial cell adhesion molecule",TRUE
+"218306_s_at",0.517654151778308,0.0366531600381038,-2.22393782891408,-3.78104175606929,-0.865854577956284,"HERC1","HECT and RLD domain containing E3 ubiquitin protein ligase family member 1",TRUE
+"240703_s_at",0.672434875127089,0.138247894130605,-1.53783720809698,-4.84911150686923,-1.09649417624943,"HERC1","HECT and RLD domain containing E3 ubiquitin protein ligase family member 1",TRUE
+"240702_at",0.912722788750542,0.634215480775073,0.482454159594792,-5.82694519014392,0.307791536356504,"HERC1","HECT and RLD domain containing E3 ubiquitin protein ligase family member 1",TRUE
+"217902_s_at",0.868397087637799,0.5035311642903,0.68002728647386,-5.71692302791453,0.262506776924923,"HERC2","HECT and RLD domain containing E3 ubiquitin protein ligase 2",TRUE
+"232900_at",0.659149453074877,0.127128138686321,1.58503653335759,-4.78491758445835,0.994023884197982,"HERC2P7","hect domain and RLD 2 pseudogene 7",TRUE
+"235902_at",0.774230543658252,0.286509547262434,1.09212966205538,-5.37486074823104,1.1172532853973,"HERC2P7","hect domain and RLD 2 pseudogene 7",TRUE
+"233075_at",0.859276375962637,0.4762861078983,-0.724590265686213,-5.68714544361594,-0.560508818532717,"HERC2P7","hect domain and RLD 2 pseudogene 7",TRUE
+"217317_s_at",0.90261448949227,0.601891571511635,0.529254839622017,-5.8041651586317,0.271282118232721,"HERC2P9///HERC2P2","hect domain and RLD 2 pseudogene 9///hect domain and RLD 2 pseudogene 2",TRUE
+"225988_at",0.5107581855747,0.0340318622779814,2.25935624183973,-3.71895541638287,1.13618505183303,"HERC4","HECT and RLD domain containing E3 ubiquitin protein ligase 4",TRUE
+"233509_at",0.597654932724127,0.073782500384296,1.87676376177657,-4.35589419566611,1.12010346792035,"HERC4","HECT and RLD domain containing E3 ubiquitin protein ligase 4",TRUE
+"208055_s_at",0.662575055303091,0.13042208345138,1.57070982246745,-4.80456395095375,0.893518870226245,"HERC4","HECT and RLD domain containing E3 ubiquitin protein ligase 4",TRUE
+"225989_at",0.757685936631556,0.253826025955507,1.17154101508425,-5.29242060369424,0.716770776610598,"HERC4","HECT and RLD domain containing E3 ubiquitin protein ligase 4",TRUE
+"208054_at",0.774230543658252,0.287882501974468,1.08894163484686,-5.37806325133645,0.944627635550614,"HERC4","HECT and RLD domain containing E3 ubiquitin protein ligase 4",TRUE
+"232026_at",0.870857065562116,0.510676119146168,0.668569442547852,-5.72428751711473,0.492958287190556,"HERC4","HECT and RLD domain containing E3 ubiquitin protein ligase 4",TRUE
+"219863_at",0.387357699611418,0.0127983460664126,2.70796291689954,-2.88685757650503,1.96864391500948,"HERC5","HECT and RLD domain containing E3 ubiquitin protein ligase 5",TRUE
+"219352_at",0.584828007864693,0.0650358764934036,1.94138429839178,-4.25383992494497,1.47620151717642,"HERC6","HECT and RLD domain containing E3 ubiquitin protein ligase family member 6",TRUE
+"1563659_at",0.99663793883595,0.983326223969275,0.0211361687754246,-5.93946589366282,0.0146764923430904,"HERC6","HECT and RLD domain containing E3 ubiquitin protein ligase family member 6",TRUE
+"217168_s_at",0.721868021715132,0.198030150118066,-1.3269762613602,-5.11659797157189,-0.581863899103132,"HERPUD1","homocysteine inducible ER protein with ubiquitin like domain 1",TRUE
+"1569380_a_at",0.97928472590149,0.899784685867767,0.127385062182147,-5.93178301896925,0.0681964105544655,"HERPUD1","homocysteine inducible ER protein with ubiquitin like domain 1",TRUE
+"1558699_a_at",0.480821812857811,0.0271652232266626,2.36556682623504,-3.5293435983387,0.857273780460426,"HERPUD2","HERPUD family member 2",TRUE
+"1552628_a_at",0.655745626967443,0.124204445110009,1.59801379075127,-4.76700157478779,0.592569356755865,"HERPUD2","HERPUD family member 2",TRUE
+"222751_at",0.690049575203937,0.159730542730334,1.45485728537575,-4.9582081304209,0.480161774610796,"HERPUD2","HERPUD family member 2",TRUE
+"203393_at",0.789850877773366,0.318757377559567,1.01995672944453,-5.44530364020347,0.462394756167666,"HES1","hes family bHLH transcription factor 1",TRUE
+"203395_s_at",0.922168942129244,0.667584183217846,0.4352600423219,-5.84782763704256,0.297741710571128,"HES1","hes family bHLH transcription factor 1",TRUE
+"203394_s_at",0.973071267819624,0.869702838190345,0.165947985487656,-5.92627927330222,0.12929779218617,"HES1","hes family bHLH transcription factor 1",TRUE
+"216674_at",0.304824368772306,0.00597729573326975,3.04005772498055,-2.22673472269179,2.25711142466992,"HES2","hes family bHLH transcription factor 2",TRUE
+"231928_at",0.327864702134751,0.00761806573018935,2.93549073684115,-2.43787935653228,2.15736581241903,"HES2","hes family bHLH transcription factor 2",TRUE
+"214521_at",0.532645544683811,0.041968669528996,2.15867797266445,-3.89386849937383,1.95528660056473,"HES2","hes family bHLH transcription factor 2",TRUE
+"227347_x_at",0.909441642299191,0.623824485710332,0.497375125352547,-5.81990583763389,0.222508217407526,"HES4","hes family bHLH transcription factor 4",TRUE
+"239230_at",0.579036829255831,0.0619698889951533,1.96585637207795,-4.2145710237443,1.52513202915016,"HES5","hes family bHLH transcription factor 5",TRUE
+"226446_at",0.16767133696705,0.00138307769496368,-3.65451834489007,-0.942460204061621,-2.57892552121702,"HES6","hes family bHLH transcription factor 6",TRUE
+"224548_at",0.683019114815084,0.151661441473709,1.48489278490295,-4.91928119606302,0.600670128718511,"HES7","hes family bHLH transcription factor 7",TRUE
+"211267_at",0.943988850936011,0.749416698659716,-0.323410957153455,-5.88886729429307,-0.255640769551567,"HESX1","HESX homeobox 1",TRUE
+"243511_at",0.825019652722105,0.392378915361289,0.872338989785793,-5.5756853618102,0.322257184617977,"HEXA","hexosaminidase subunit alpha",TRUE
+"201765_s_at",0.862800800218883,0.486486974819008,-0.707737528596657,-5.69861840924637,-0.323641869477902,"HEXA","hexosaminidase subunit alpha",TRUE
+"1556426_at",0.89205696974366,0.562513912132642,-0.587945861518002,-5.77270348388992,-0.187985662221819,"HEXA","hexosaminidase subunit alpha",TRUE
+"215155_at",0.975514010346705,0.88327353128786,0.148522944322019,-5.92894503143578,0.106069731892161,"HEXA","hexosaminidase subunit alpha",TRUE
+"220718_at",0.622434989367596,0.0930713092200477,-1.75504396733403,-4.54141375515402,-1.169749705297,"HEXA-AS1","HEXA antisense RNA 1",TRUE
+"201944_at",0.974884920935236,0.877094736738754,-0.156450470534787,-5.92776878557561,-0.0560811379059238,"HEXB","hexosaminidase subunit beta",TRUE
+"1555866_a_at",0.969859842767097,0.855887869345338,-0.183740909889361,-5.92325324300695,-0.0582459186367128,"HEXDC","hexosaminidase D",TRUE
+"238033_at",0.996771621728225,0.983624723780538,-0.0207577243154712,-5.93947361564762,-0.0139794934193125,"HEXDC","hexosaminidase D",TRUE
+"238442_at",0.748718199988147,0.241685002498232,1.20297079682837,-5.25839250708377,0.331248510443685,"HEXIM1","hexamethylene bisacetamide inducible 1",TRUE
+"202815_s_at",0.775425121726686,0.292342716674022,-1.07865990881585,-5.38833476955501,-0.570974989646023,"HEXIM1","hexamethylene bisacetamide inducible 1",TRUE
+"202814_s_at",0.975475861996229,0.883104189796367,-0.14874008089044,-5.92891362657255,-0.0593163996550992,"HEXIM1","hexamethylene bisacetamide inducible 1",TRUE
+"238547_at",0.971511156698413,0.864346753083253,-0.172839500815648,-5.92514366955991,-0.0631605572264959,"HEXIM2","hexamethylene bisacetamide inducible 2",TRUE
+"243796_at",0.997890350692744,0.990121612546476,-0.0125215020071798,-5.93960711537744,-0.0054152650957402,"HEXIM2","hexamethylene bisacetamide inducible 2",TRUE
+"218839_at",0.704092960947689,0.175888679611094,1.39821586130122,-5.02984817075247,1.4195340880006,"HEY1","hes related family bHLH transcription factor with YRPW motif 1",TRUE
+"44783_s_at",0.841550580403629,0.432725377709033,0.799083006526238,-5.63337276959071,0.444151172133081,"HEY1","hes related family bHLH transcription factor with YRPW motif 1",TRUE
+"219743_at",0.711989638658417,0.185972736934695,-1.36494140505585,-5.07083777213298,-1.54084055141022,"HEY2","hes related family bHLH transcription factor with YRPW motif 2",TRUE
+"222921_s_at",0.724590981430178,0.201872114610812,-1.31526007108652,-5.13050052958892,-1.84108839685371,"HEY2","hes related family bHLH transcription factor with YRPW motif 2",TRUE
+"226828_s_at",0.837393127867504,0.421399808324582,0.81919484046655,-5.61800643979351,0.417967201371852,"HEYL","hes related family bHLH transcription factor with YRPW motif-like",TRUE
+"220662_s_at",0.843157049709934,0.437593496891981,0.790538584520909,-5.6397924254619,0.302216472232443,"HEYL","hes related family bHLH transcription factor with YRPW motif-like",TRUE
+"211331_x_at",0.528176582660474,0.0406806481037909,2.17377231706465,-3.86795646284681,2.14640744261135,"HFE","hemochromatosis",TRUE
+"211332_x_at",0.587626678796111,0.0665935030555344,1.92933899518646,-4.2730443680484,0.94108977599096,"HFE","hemochromatosis",TRUE
+"211330_s_at",0.602176237741593,0.0770891908366798,1.85407244760784,-4.3911545503999,1.61952639014852,"HFE","hemochromatosis",TRUE
+"206086_x_at",0.622434989367596,0.0925796683247799,1.75786315003284,-4.53721934820557,0.7202257266199,"HFE","hemochromatosis",TRUE
+"214647_s_at",0.627498001755657,0.0990568862030741,1.72170578291464,-4.59063624022274,1.68017008497659,"HFE","hemochromatosis",TRUE
+"211863_x_at",0.631316839203356,0.102530697081589,1.70313839369931,-4.61774492589454,0.653625469483588,"HFE","hemochromatosis",TRUE
+"211866_x_at",0.637485146909712,0.108298064129259,1.67346021069855,-4.66061577173788,0.859039699010638,"HFE","hemochromatosis",TRUE
+"235754_at",0.65284137151906,0.121675112480556,1.6094476964041,-4.75112217537387,1.11768792907575,"HFE","hemochromatosis",TRUE
+"1553402_a_at",0.659870891937597,0.127684179511707,1.5825966197628,-4.78827332188796,1.57464716260449,"HFE","hemochromatosis",TRUE
+"211326_x_at",0.661974206478491,0.129283336112839,1.57562837399094,-4.79783483699188,0.636157196554676,"HFE","hemochromatosis",TRUE
+"211327_x_at",0.68033297785336,0.147730865722799,1.49999658668909,-4.89946403460232,0.864385167989335,"HFE","hemochromatosis",TRUE
+"211329_x_at",0.69410086222651,0.16355009434045,1.44106620289665,-4.97586531256899,1.42229233790702,"HFE","hemochromatosis",TRUE
+"210864_x_at",0.710824498521146,0.184069928707936,1.37110872340172,-5.06330240250825,0.526548845943404,"HFE","hemochromatosis",TRUE
+"206087_x_at",0.728385463227073,0.209815081698558,1.29157754462519,-5.15828378692751,1.02907442716117,"HFE","hemochromatosis",TRUE
+"211328_x_at",0.732443812350949,0.216806047719941,1.27130094753063,-5.18173016150597,0.457857511464169,"HFE","hemochromatosis",TRUE
+"228621_at",0.97825928502075,0.895243616081682,0.133192282531902,-5.93104658326986,0.0604721878105341,"HFE2","hemochromatosis type 2 (juvenile)",TRUE
+"241469_at",0.73957587762701,0.228019035856042,1.23980336786015,-5.21752159578843,1.26449392072123,"HFM1","HFM1, ATP dependent DNA helicase homolog",TRUE
+"1564285_at",0.947926063538122,0.762855970414224,0.305474816146158,-5.8943351746342,0.199474985645424,"HFM1","HFM1, ATP dependent DNA helicase homolog",TRUE
+"211111_at",0.961475152596758,0.825340051484934,-0.223310255926631,-5.91542402025597,-0.124980165277636,"HGC6.3","uncharacterized LOC100128124",TRUE
+"214308_s_at",0.358427723880268,0.0101314507958842,-2.81115991929723,-2.68512796338761,-2.79117323199147,"HGD","homogentisate 1,2-dioxygenase",TRUE
+"205221_at",0.586972146297368,0.0662819575901226,-1.9317282204246,-4.26924164717927,-3.19646327332443,"HGD","homogentisate 1,2-dioxygenase",TRUE
+"214307_at",0.610033432202476,0.0824439079637848,-1.8190631248027,-4.44495583401732,-2.4082385524716,"HGD","homogentisate 1,2-dioxygenase",TRUE
+"237029_at",0.897949253801113,0.586547428703041,-0.55189046202211,-5.792411316009,-0.618509259380184,"HGD","homogentisate 1,2-dioxygenase",TRUE
+"210755_at",0.597654932724127,0.0737305520521299,1.87712726852847,-4.35532687333101,0.868735486397663,"HGF","hepatocyte growth factor",TRUE
+"210997_at",0.719412173140763,0.195458136203211,1.33491933719594,-5.10711359561806,0.60743633608668,"HGF","hepatocyte growth factor",TRUE
+"209961_s_at",0.805267504135671,0.344533445957371,0.965871415480329,-5.49523517997844,0.559865279881032,"HGF","hepatocyte growth factor",TRUE
+"210998_s_at",0.841618504666446,0.433454695434887,-0.797799157471179,-5.63434150369594,-0.378698932667008,"HGF","hepatocyte growth factor",TRUE
+"209960_at",0.955892698633978,0.799431651981557,0.257155670714452,-5.9075256925562,0.183678492664722,"HGF","hepatocyte growth factor",TRUE
+"207027_at",0.64513208805899,0.115960299246836,1.63603231957226,-4.7138634236915,0.789245610741231,"HGFAC","HGF activator",TRUE
+"221629_x_at",0.8920930097751,0.564003002642646,0.585689393676448,-5.77397227880981,0.206247725658647,"HGH1","HGH1 homolog",TRUE
+"219071_x_at",0.990681070320481,0.952902011671771,0.0597352557383374,-5.93794564244249,0.0231777760160217,"HGH1","HGH1 homolog",TRUE
+"232627_at",0.710842845257879,0.184548947719106,1.36955141214669,-5.0652078302222,0.516832628845158,"HGS","hepatocyte growth factor-regulated tyrosine kinase substrate",TRUE
+"210428_s_at",0.821745015752602,0.384698127448321,-0.886825052100035,-5.56372054442373,-0.29745790855646,"HGS","hepatocyte growth factor-regulated tyrosine kinase substrate",TRUE
+"1557064_s_at",0.90390171502042,0.605444693323783,-0.524053377186883,-5.80679842016335,-0.162351719256645,"HGSNAT","heparan-alpha-glucosaminide N-acetyltransferase",TRUE
+"222491_at",0.904381089098038,0.607522203537833,-0.521018858627789,-5.80832295956021,-0.266902520613673,"HGSNAT","heparan-alpha-glucosaminide N-acetyltransferase",TRUE
+"218017_s_at",0.97979222603145,0.903471769755845,-0.122673245313651,-5.93235645861276,-0.0660183471835065,"HGSNAT","heparan-alpha-glucosaminide N-acetyltransferase",TRUE
+"238090_at",0.986342822130003,0.934125038801399,-0.0836001944342366,-5.93627997341173,-0.0333349770314362,"HGSNAT","heparan-alpha-glucosaminide N-acetyltransferase",TRUE
+"227564_at",0.986342822130003,0.934417202171543,0.0832285196288935,-5.93631016413749,0.0819940415394358,"HGSNAT","heparan-alpha-glucosaminide N-acetyltransferase",TRUE
+"219687_at",0.93795089554339,0.725588862878889,-0.355484146709979,-5.87832054337032,-0.173905780486644,"HHAT","hedgehog acyltransferase",TRUE
+"223572_at",0.885029460971826,0.545278292176482,-0.614293273547124,-5.7575398221493,-0.393782159740292,"HHATL","hedgehog acyltransferase-like",TRUE
+"234382_x_at",0.834665558884683,0.413233873131221,-0.833906803567676,-5.60653925629742,-0.687296435187327,"HHCM","Mahlavu hepatocellular carcinoma",TRUE
+"204689_at",0.622434989367596,0.0924093555310901,1.75884275839442,-4.53576071672288,1.54012864054205,"HHEX","hematopoietically expressed homeobox",TRUE
+"215933_s_at",0.690015152288705,0.159669190983191,1.45508096811791,-4.95792061443143,1.3221667019056,"HHEX","hematopoietically expressed homeobox",TRUE
+"1556037_s_at",0.89316156038085,0.566912225547514,0.581289777959453,-5.77643257432501,0.433020930498317,"HHIP","hedgehog interacting protein",TRUE
+"223775_at",0.910276798053706,0.627134067855253,-0.492610453278578,-5.82217645858922,-0.359148428007037,"HHIP","hedgehog interacting protein",TRUE
+"230135_at",0.913221029035633,0.635912873272366,-0.480027395777297,-5.82807026386525,-0.379020852181011,"HHIP","hedgehog interacting protein",TRUE
+"237466_s_at",0.977930820766623,0.893500551892301,0.135422586776063,-5.93075504072389,0.059875838689452,"HHIP","hedgehog interacting protein",TRUE
+"236632_at",0.96200396340887,0.827570083159304,0.220410054873432,-5.91604932735289,0.165317459950828,"HHIP-AS1","HHIP antisense RNA 1",TRUE
+"1559237_a_at",0.712975827977365,0.187341431901945,1.36053599416257,-5.07620306385913,0.673549158405993,"HHIPL1","HHIP like 1",TRUE
+"1556564_at",0.885029460971826,0.545358446985819,-0.614169738497696,-5.75761241646469,-0.276902769789054,"HHIPL1","HHIP like 1",TRUE
+"220283_at",0.841247691968787,0.431344317829448,0.80151781856494,-5.63153154983282,0.34677380973713,"HHIPL2","HHIP like 2",TRUE
+"221162_at",0.867087759460417,0.498763786648928,-0.687723446044975,-5.71190917080087,-0.320791944797966,"HHLA1","HERV-H LTR-associating 1",TRUE
+"233767_at",0.90013973339985,0.59475899421679,-0.539741283361938,-5.79877942565315,-0.182950645960102,"HHLA1","HERV-H LTR-associating 1",TRUE
+"234673_at",0.705559553212919,0.177475295640648,1.39288169988649,-5.03647417982899,0.908879619367158,"HHLA2","HERV-H LTR-associating 2",TRUE
+"220812_s_at",0.774230543658252,0.287711051262593,1.08933914668928,-5.3776643896985,0.843489775231344,"HHLA2","HERV-H LTR-associating 2",TRUE
+"1560226_at",0.930686774664133,0.69302333163056,0.399949596349107,-5.86207191609401,0.308991743271883,"HHLA2","HERV-H LTR-associating 2",TRUE
+"234665_x_at",0.456898036702485,0.0224324475071051,2.45431812559581,-3.36716080295438,1.00570631141289,"HHLA3","HERV-H LTR-associating 3",TRUE
+"234703_at",0.637236149092845,0.108132843192226,1.67429157561909,-4.65942260602813,1.24747828731712,"HHLA3","HERV-H LTR-associating 3",TRUE
+"220387_s_at",0.64513208805899,0.115801333575046,1.63678737812623,-4.71279833501826,1.05552603677362,"HHLA3","HERV-H LTR-associating 3",TRUE
+"234452_at",0.687687878306067,0.156756360810764,1.46578176472632,-4.94412418732252,0.636858756607921,"HIBADH","3-hydroxyisobutyrate dehydrogenase",TRUE
+"231955_s_at",0.951810226174863,0.779084708744394,0.283950751458438,-5.90048866237786,0.125501195790687,"HIBADH","3-hydroxyisobutyrate dehydrogenase",TRUE
+"224812_at",0.976589025744684,0.888682008128948,0.141591759880406,-5.92992344382207,0.0585807487720622,"HIBADH","3-hydroxyisobutyrate dehydrogenase",TRUE
+"203711_s_at",0.806649582904638,0.347609429386633,-0.959605108542112,-5.50085994929695,-0.38482576885171,"HIBCH","3-hydroxyisobutyryl-CoA hydrolase",TRUE
+"213374_x_at",0.983567332578112,0.919814100939835,-0.101821652710415,-5.9346350424912,-0.0426883840759835,"HIBCH","3-hydroxyisobutyryl-CoA hydrolase",TRUE
+"208461_at",0.571677937624457,0.0595170323797151,1.98621766855611,-4.18164398871901,0.765182833296373,"HIC1","hypermethylated in cancer 1",TRUE
+"230218_at",0.861659105448003,0.482925485563039,0.713597874188239,-5.69465795904129,0.621608730305287,"HIC1","hypermethylated in cancer 1",TRUE
+"212965_at",0.567292616148537,0.057326519648161,2.00503995957958,-4.15100266867596,1.17851628392063,"HIC2","hypermethylated in cancer 2",TRUE
+"216911_s_at",0.669064910711768,0.135134591842525,1.55072592224848,-4.83173387843715,0.86498867328177,"HIC2","hypermethylated in cancer 2",TRUE
+"212966_at",0.774230543658252,0.289999810159256,1.08404661591028,-5.38296425184128,0.576844998253337,"HIC2","hypermethylated in cancer 2",TRUE
+"212964_at",0.874834820370747,0.521652762939682,0.651139839995438,-5.73526034123767,0.360302726714117,"HIC2","hypermethylated in cancer 2",TRUE
+"225981_at",0.634499515855866,0.105548563782474,-1.68743722181614,-4.64049651007303,-1.25505795960532,"HID1","HID1 domain containing",TRUE
+"244593_at",0.897699110987203,0.585199121116295,-0.553893313925053,-5.79134828348,-0.693549742307692,"HID1","HID1 domain containing",TRUE
+"200989_at",0.98672253748883,0.938110836243505,0.0785306911741678,-5.9366801749387,0.0352716382278224,"HIF1A","hypoxia inducible factor 1 alpha subunit",TRUE
+"226648_at",0.844151170826322,0.440440794698903,0.785568160906359,-5.6434969517388,0.220288576810537,"HIF1AN","hypoxia inducible factor 1 alpha subunit inhibitor",TRUE
+"59999_at",0.916107385524794,0.646198496056432,-0.465383733850239,-5.83474139071183,-0.127274677943237,"HIF1AN","hypoxia inducible factor 1 alpha subunit inhibitor",TRUE
+"218525_s_at",0.983783029912313,0.9209163553514,0.100417027608142,-5.93477333412314,0.0264042868152963,"HIF1AN","hypoxia inducible factor 1 alpha subunit inhibitor",TRUE
+"219319_at",0.0606661777092667,0.000138697251278616,4.59537034924556,1.0845854362445,1.72836096631757,"HIF3A","hypoxia inducible factor 3 alpha subunit",TRUE
+"232669_at",0.265291226630601,0.00403698766450225,3.20726940901202,-1.88380377263929,1.38208537823222,"HIF3A","hypoxia inducible factor 3 alpha subunit",TRUE
+"222123_s_at",0.650490742096872,0.120615656122825,1.61429605914991,-4.74436228004594,0.802132708399775,"HIF3A","hypoxia inducible factor 3 alpha subunit",TRUE
+"1556069_s_at",0.689848451630875,0.1589698432675,1.45763564696133,-4.95463434957597,0.8864051508059,"HIF3A","hypoxia inducible factor 3 alpha subunit",TRUE
+"222124_at",0.800887499728059,0.336822202020977,-0.981750328491576,-5.48083236138405,-0.597867777903296,"HIF3A","hypoxia inducible factor 3 alpha subunit",TRUE
+"233517_s_at",0.813442508625161,0.363998252767727,0.926835896224636,-5.52972743438393,0.374303135788976,"HIF3A","hypoxia inducible factor 3 alpha subunit",TRUE
+"1555318_at",0.995373963163252,0.978297405733949,-0.0275123329898468,-5.93931481552558,-0.0197115496373055,"HIF3A","hypoxia inducible factor 3 alpha subunit",TRUE
+"221896_s_at",0.915939421175188,0.645246747871964,-0.466734362869222,-5.83413456175384,-0.206265048171675,"HIGD1A","HIG1 hypoxia inducible domain family member 1A",TRUE
+"242317_at",0.978240571220736,0.894488506952163,-0.134158382270103,-5.93092088926074,-0.064449746053608,"HIGD1A","HIG1 hypoxia inducible domain family member 1A",TRUE
+"217845_x_at",0.990681070320481,0.952901126457376,-0.0597363798688759,-5.93794557704032,-0.0212427950713963,"HIGD1A","HIG1 hypoxia inducible domain family member 1A",TRUE
+"219719_at",0.95396321837061,0.787668907075405,0.27262139192753,-5.90354846199447,0.178985451202985,"HIGD1B","HIG1 hypoxia inducible domain family member 1B",TRUE
+"209329_x_at",0.554642754132296,0.0510715486364764,-2.06254526755101,-4.05620236803644,-0.583627160233915,"HIGD2A","HIG1 hypoxia inducible domain family member 2A",TRUE
+"209328_x_at",0.745717401914776,0.237379054375422,-1.21440238389293,-5.24582171078045,-0.339699827004375,"HIGD2A","HIG1 hypoxia inducible domain family member 2A",TRUE
+"230326_s_at",0.909052380289506,0.622539867011846,-0.499227681860889,-5.81901723346764,-0.18711106643326,"HIKESHI","Hikeshi, heat shock protein nuclear import factor",TRUE
+"219979_s_at",0.921006039723366,0.663899223366755,-0.440420774967203,-5.84564668717692,-0.160419584317363,"HIKESHI","Hikeshi, heat shock protein nuclear import factor",TRUE
+"1554452_a_at",0.595936234743389,0.0724450605918844,-1.88619452762426,-4.34115067323678,-0.970021093054619,"HILPDA","hypoxia inducible lipid droplet associated",TRUE
+"218507_at",0.617775129514679,0.0887433973984803,-1.78031401856509,-4.50364040791116,-0.879476210655904,"HILPDA","hypoxia inducible lipid droplet associated",TRUE
+"231229_at",0.864549535575582,0.491876812638393,-0.698915593905951,-5.70452161838739,-0.731860121496188,"HILS1","histone linker H1 domain, spermatid-specific 1 (pseudogene)",TRUE
+"206495_s_at",0.977143718344719,0.89099642007277,0.138627935131139,-5.93032757804975,0.0386136319247399,"HINFP","histone H4 transcription factor",TRUE
+"200093_s_at",0.89748872632674,0.584204381205474,-0.555372425726225,-5.79056083115298,-0.134815518469319,"HINT1","histidine triad nucleotide binding protein 1",TRUE
+"207721_x_at",0.943464796017993,0.746497984096925,0.327320432720436,-5.88763448921484,0.0863579433067425,"HINT1","histidine triad nucleotide binding protein 1",TRUE
+"1555960_at",0.969642324744141,0.855012156395957,-0.184870766959082,-5.92305072329319,-0.121656242209747,"HINT1","histidine triad nucleotide binding protein 1",TRUE
+"208826_x_at",0.969891556938326,0.857495893385308,0.181666850920313,-5.92362178404049,0.0423849874561419,"HINT1","histidine triad nucleotide binding protein 1",TRUE
+"1555961_a_at",0.995375928428862,0.978480754614833,0.0272798414752705,-5.93932101985985,0.00589093236387406,"HINT1","histidine triad nucleotide binding protein 1",TRUE
+"224415_s_at",0.95425391457907,0.789635296887076,-0.270031342913591,-5.90423060681426,-0.0893103057722477,"HINT2","histidine triad nucleotide binding protein 2",TRUE
+"226533_at",0.928586479058937,0.686058542690183,0.40956375942798,-5.8583109206851,0.224748981738705,"HINT3","histidine triad nucleotide binding protein 3",TRUE
+"226537_at",0.973433731874338,0.871646967549764,0.163448583596338,-5.92667974599427,0.0672431318539104,"HINT3","histidine triad nucleotide binding protein 3",TRUE
+"228697_at",0.997470525710394,0.987272335973364,0.0161334372158647,-5.93955670495538,0.00952932911862803,"HINT3","histidine triad nucleotide binding protein 3",TRUE
+"205425_at",0.743222421697179,0.233331739706119,1.22529097957102,-5.23375230987573,0.989274348498963,"HIP1","huntingtin interacting protein 1",TRUE
+"1560317_s_at",0.784124594631274,0.307217788607565,-1.04516089103333,-5.4211950964283,-0.796801895972181,"HIP1","huntingtin interacting protein 1",TRUE
+"226364_at",0.841420204214686,0.432365358526385,0.799717257102283,-5.63289365255937,1.01229257018044,"HIP1","huntingtin interacting protein 1",TRUE
+"205426_s_at",0.864894115958506,0.49362038350918,0.69607366453977,-5.70640825966018,0.391061690445742,"HIP1","huntingtin interacting protein 1",TRUE
+"209559_at",0.270441084903894,0.00421846216844215,-3.18864454566884,-1.92229401966787,-1.74203546215536,"HIP1R","huntingtin interacting protein 1 related",TRUE
+"38340_at",0.858226066210126,0.473888339074233,-0.728582102483508,-5.68439028818491,-0.35845654313295,"HIP1R","huntingtin interacting protein 1 related",TRUE
+"209558_s_at",0.88587213211399,0.547821128382041,-0.610378917307524,-5.75983321452062,-0.447898142974752,"HIP1R","huntingtin interacting protein 1 related",TRUE
+"1552516_a_at",0.68865058167867,0.157903878280094,-1.46154710028295,-4.94959370202224,-0.948030397307403,"HIPK1","homeodomain interacting protein kinase 1",TRUE
+"212291_at",0.699391325858549,0.170912567210549,-1.41519823441961,-5.00861389847008,-0.80661278705611,"HIPK1","homeodomain interacting protein kinase 1",TRUE
+"212293_at",0.812300464082654,0.356580218352954,-0.941542277659875,-5.51688590990216,-0.549659186081081,"HIPK1","homeodomain interacting protein kinase 1",TRUE
+"1552515_at",0.972659629123427,0.867841878144091,-0.16834147754478,-5.92589008887992,-0.128970423207208,"HIPK1","homeodomain interacting protein kinase 1",TRUE
+"1570080_at",0.814439884224271,0.365330283138691,-0.924216434838684,-5.53199522520383,-1.09137554702792,"HIPK1-AS1","HIPK1 antisense RNA 1",TRUE
+"1570082_x_at",0.986030024154144,0.931692420811183,0.086695316189519,-5.93602333928845,0.0507301617883655,"HIPK1-AS1","HIPK1 antisense RNA 1",TRUE
+"240294_at",0.62282585384278,0.0933354799910314,-1.75353442167964,-4.54365763145809,-0.81951379559919,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"225368_at",0.632216562924782,0.103384305425216,-1.6986579184993,-4.62425346924278,-0.96287638566155,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"225097_at",0.686108994812404,0.154710361643917,-1.47339481708817,-4.93425891303723,-0.863826905521979,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"219028_at",0.689950875648652,0.159301551369066,-1.45642280513525,-4.9561950980293,-0.563073491425724,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"225115_at",0.740476003158683,0.229506278031685,-1.23571508554318,-5.22211061559492,-0.618253030351527,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"224066_s_at",0.845487921422997,0.442590123442525,-0.781829190079558,-5.64626915138436,-0.568246941007552,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"213763_at",0.876039291047695,0.524643433751023,-0.646426182861047,-5.73818004913482,-0.357298073731149,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"224016_at",0.886943633644753,0.550777331375727,0.605840285223454,-5.76247465764465,0.287190734105764,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"225116_at",0.89316156038085,0.567390569594653,-0.580567488398752,-5.77683476794179,-0.435245671743521,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"224065_at",0.982793523378274,0.916231394122311,-0.10638863366909,-5.93417213978879,-0.102339525156619,"HIPK2","homeodomain interacting protein kinase 2",TRUE
+"210148_at",0.796301109241207,0.328526092750872,0.99911518328923,-5.46483709737798,0.405652052222383,"HIPK3","homeodomain interacting protein kinase 3",TRUE
+"226297_at",0.840225440392804,0.429279514438639,0.805167101929263,-5.62876208400449,0.418032149058405,"HIPK3","homeodomain interacting protein kinase 3",TRUE
+"213697_at",0.844608293507187,0.441436496360008,0.783834653606249,-5.64478378237143,0.27403809023761,"HIPK3","homeodomain interacting protein kinase 3",TRUE
+"207764_s_at",0.946579549170519,0.758027863829663,0.311906363978713,-5.89241003032969,0.146783485418732,"HIPK3","homeodomain interacting protein kinase 3",TRUE
+"1553238_a_at",0.970935119871645,0.861056054200771,0.17707777623854,-5.9244223970474,0.0469438891058331,"HIPK4","homeodomain interacting protein kinase 4",TRUE
+"217427_s_at",0.603702127972549,0.0780665932588574,-1.84752771889074,-4.40126793654222,-0.636158110804041,"HIRA","histone cell cycle regulator",TRUE
+"1569560_at",0.986342822130003,0.93522072625862,0.0822063805171431,-5.93639249813215,0.0581933768518503,"HIRA","histone cell cycle regulator",TRUE
+"204504_s_at",0.68033297785336,0.14754939021547,-1.50070181417241,-4.89853479642814,-0.606433769581235,"HIRIP3","HIRA interacting protein 3",TRUE
+"229697_at",0.984161165881616,0.922705896440801,-0.098137018588619,-5.93499372533258,-0.0340025350590771,"HIRIP3","HIRA interacting protein 3",TRUE
+"208484_at",0.38316799526015,0.0121730737588821,2.73019118083738,-2.84369053123744,1.85686661218792,"HIST1H1A","histone cluster 1, H1a",TRUE
+"214534_at",0.926157593982359,0.679368568161985,0.418835681611375,-5.85460055963696,0.305608830424767,"HIST1H1B","histone cluster 1, H1b",TRUE
+"209398_at",0.741734366005262,0.232220868267123,-1.22830457744471,-5.23039545501708,-0.928906140396212,"HIST1H1C","histone cluster 1, H1c",TRUE
+"214537_at",0.748184017928985,0.240340060279023,-1.20652480319925,-5.2544953772615,-0.869488592659611,"HIST1H1D","histone cluster 1, H1d",TRUE
+"208553_at",0.724067243569133,0.201423199587133,-1.3166200297103,-5.12889212502675,-0.807051847896818,"HIST1H1E","histone cluster 1, H1e",TRUE
+"1553568_a_at",0.647754107214051,0.118979315939897,1.62185486468637,-4.73379195607272,0.471840373066359,"HIST1H1T","histone cluster 1, H1t",TRUE
+"207982_at",0.926857684508708,0.681034853542804,-0.416522843151285,-5.85553373888363,-0.333814243392462,"HIST1H1T","histone cluster 1, H1t",TRUE
+"208569_at",0.987487323337591,0.941065875510489,-0.0747735691750736,-5.93696063545445,-0.0258534957152774,"HIST1H2AB","histone cluster 1, H2ab",TRUE
+"215071_s_at",0.922244100278602,0.668162553364754,-0.434451136500027,-5.84816719641425,-0.314334720823606,"HIST1H2AC","histone cluster 1, H2ac",TRUE
+"214469_at",0.879960488971225,0.534952504230154,-0.630289219335642,-5.74802112798705,-0.742972194375344,"HIST1H2AE","histone cluster 1, H2ae",TRUE
+"214542_x_at",0.761006638483723,0.260110267027415,-1.15571109676456,-5.30926075558077,-0.617721510483396,"HIST1H2AH///HIST1H2AG///HIST1H2AM///HIST1H2AL///HIST1H2AK///HIST1H2AI","histone cluster 1, H2ah///histone cluster 1, H2ag///histone cluster 1, H2am///histone cluster 1, H2al///histone cluster 1, H2ak///histone cluster 1, H2ai",TRUE
+"207156_at",0.860273226754149,0.479723281399309,0.718888481553767,-5.69105584217613,0.947601334127453,"HIST1H2AH///HIST1H2AG///HIST1H2AM///HIST1H2AL///HIST1H2AK///HIST1H2AI","histone cluster 1, H2ah///histone cluster 1, H2ag///histone cluster 1, H2am///histone cluster 1, H2al///histone cluster 1, H2ak///histone cluster 1, H2ai",TRUE
+"208583_x_at",0.863767923323804,0.489428994322295,-0.702915180606258,-5.7018540365376,-0.265368293860913,"HIST1H2AJ","histone cluster 1, H2aj",TRUE
+"239041_at",0.958587459575795,0.812318295019925,0.240285357219326,-5.9116009523246,0.0968694102069136,"HIST1H2AK","histone cluster 1, H2ak",TRUE
+"214644_at",0.990810941805126,0.955696464652849,-0.0561869753954529,-5.93814595101163,-0.0542180412423852,"HIST1H2AK","histone cluster 1, H2ak",TRUE
+"214554_at",0.93032716386748,0.691946547512039,0.401433456927223,-5.86149717918703,0.171673077723537,"HIST1H2AL","histone cluster 1, H2al",TRUE
+"214481_at",0.829030239823335,0.400163457872476,-0.857843573300251,-5.58747457137777,-0.564997000990361,"HIST1H2AM","histone cluster 1, H2am",TRUE
+"234960_at",0.55937703282623,0.0533129908840548,-2.04125057623371,-4.09151376328854,-1.21677689381816,"HIST1H2APS5","histone cluster 1, H2a, pseudogene 5",TRUE
+"241519_at",0.92777930247318,0.683295955717041,0.413388074717615,-5.85679043684122,0.339003716431264,"HIST1H2BA","histone cluster 1, H2ba",TRUE
+"208547_at",0.704396794850573,0.17627071616389,-1.39692797237503,-5.03144988212646,-1.04581266379789,"HIST1H2BB","histone cluster 1, H2bb",TRUE
+"236193_at",0.913895480987494,0.638691592029223,0.476060953029692,-5.82989720177606,0.345688378994475,"HIST1H2BC","histone cluster 1, H2bc",TRUE
+"208523_x_at",0.76524135343539,0.265437415815099,-1.14251222490951,-5.32314807154013,-0.770477840764004,"HIST1H2BC///HIST1H2BI///HIST1H2BE///HIST1H2BF///HIST1H2BG","histone cluster 1, H2bc///histone cluster 1, H2bi///histone cluster 1, H2be///histone cluster 1, H2bf///histone cluster 1, H2bg",TRUE
+"208490_x_at",0.888620025103314,0.55490196428125,-0.59952911622978,-5.76611606859252,-0.357444132655719,"HIST1H2BC///HIST1H2BI///HIST1H2BE///HIST1H2BF///HIST1H2BG","histone cluster 1, H2bc///histone cluster 1, H2bi///histone cluster 1, H2be///histone cluster 1, H2bf///histone cluster 1, H2bg",TRUE
+"214455_at",0.923587277947433,0.672000802529972,-0.429090405034098,-5.85040182510052,-0.274409797309383,"HIST1H2BC///HIST1H2BI///HIST1H2BE///HIST1H2BF///HIST1H2BG","histone cluster 1, H2bc///histone cluster 1, H2bi///histone cluster 1, H2be///histone cluster 1, H2bf///histone cluster 1, H2bg",TRUE
+"209911_x_at",0.8877101263145,0.552751803185357,-0.602816032955838,-5.76422418132889,-0.422698902293812,"HIST1H2BD","histone cluster 1, H2bd",TRUE
+"222067_x_at",0.912906062613339,0.634731261057405,-0.481716437799773,-5.82728779279208,-0.311788231241168,"HIST1H2BD","histone cluster 1, H2bd",TRUE
+"208527_x_at",0.861659105448003,0.482708200972536,-0.713956220479145,-5.69441477803375,-0.376458292982266,"HIST1H2BE","histone cluster 1, H2be",TRUE
+"208546_x_at",0.76029267756668,0.258752516066459,-1.15910704221519,-5.30566501509905,-0.689986420611998,"HIST1H2BH","histone cluster 1, H2bh",TRUE
+"214502_at",0.982774118455239,0.916195328610553,-0.106434619049191,-5.93416737561999,-0.0999606068039887,"HIST1H2BJ","histone cluster 1, H2bj",TRUE
+"215779_s_at",0.869060996512026,0.505577544481718,-0.676736370089533,-5.71905050971368,-0.765578214763941,"HIST1H2BJ///HIST1H2BG","histone cluster 1, H2bj///histone cluster 1, H2bg",TRUE
+"210387_at",0.897024165042344,0.583015094858158,-0.557142460737604,-5.78961581754491,-0.626076159603818,"HIST1H2BJ///HIST1H2BG","histone cluster 1, H2bj///histone cluster 1, H2bg",TRUE
+"209806_at",0.769847953580141,0.278028631368239,-1.11207149947661,-5.35463953642646,-0.522990963804974,"HIST1H2BK","histone cluster 1, H2bk",TRUE
+"207611_at",0.606103871227474,0.0796056848880799,-1.83736494169529,-4.41692164322255,-1.11083965958987,"HIST1H2BL","histone cluster 1, H2bl",TRUE
+"208515_at",0.861117006945129,0.481359288216991,0.716182950600276,-5.6929010697504,0.299188067192875,"HIST1H2BM","histone cluster 1, H2bm",TRUE
+"207226_at",0.99783553534859,0.989849675350141,-0.012866219797581,-5.93960285282917,-0.00701973950792745,"HIST1H2BN","histone cluster 1, H2bn",TRUE
+"214540_at",0.868070875029484,0.502060122728529,-0.682397628330056,-5.71538455667658,-0.538851215457841,"HIST1H2BO","histone cluster 1, H2bo",TRUE
+"208575_at",0.689848451630875,0.159015272718865,-1.45746941999507,-4.95484832154691,-1.24895329430674,"HIST1H3A","histone cluster 1, H3a",TRUE
+"208576_s_at",0.864984002738957,0.494093309375025,-0.695303811321904,-5.70691807127586,-0.473979628344042,"HIST1H3B","histone cluster 1, H3b",TRUE
+"208577_at",0.960857829396113,0.822069626762174,0.227567061864899,-5.91449148620803,0.182476501730772,"HIST1H3C","histone cluster 1, H3c",TRUE
+"214522_x_at",0.944785393058556,0.751558633726829,-0.320545210987906,-5.88976165749006,-0.36491624338538,"HIST1H3D///HIST1H2AD","histone cluster 1, H3d///histone cluster 1, H2ad",TRUE
+"236278_at",0.89316156038085,0.56732759036287,-0.580662567898386,-5.7767818523408,-0.476649925812316,"HIST1H3E","histone cluster 1, H3e",TRUE
+"214616_at",0.895690630367785,0.575939445974189,-0.567710817069328,-5.7839127228979,-0.213181885189359,"HIST1H3E","histone cluster 1, H3e",TRUE
+"208506_at",0.516444287133032,0.0363575348136995,2.22781462646163,-3.77427473584293,0.708197876081434,"HIST1H3F","histone cluster 1, H3f",TRUE
+"214646_at",0.614178202960275,0.0851914061061315,-1.80185902083309,-4.47112409886571,-1.16766131709163,"HIST1H3F///HIST1H3B///HIST1H3H///HIST1H3J///HIST1H3G///HIST1H3I///HIST1H3E///HIST1H3C///HIST1H3D///HIST1H3A","histone cluster 1, H3f///histone cluster 1, H3b///histone cluster 1, H3h///histone cluster 1, H3j///histone cluster 1, H3g///histone cluster 1, H3i///histone cluster 1, H3e///histone cluster 1, H3c///histone cluster 1, H3d///histone cluster 1, H3a",TRUE
+"206110_at",0.707694888507328,0.179201389729617,-1.38712154401559,-5.04360581829031,-1.19436733400767,"HIST1H3F///HIST1H3B///HIST1H3H///HIST1H3J///HIST1H3G///HIST1H3I///HIST1H3E///HIST1H3C///HIST1H3D///HIST1H3A","histone cluster 1, H3f///histone cluster 1, H3b///histone cluster 1, H3h///histone cluster 1, H3j///histone cluster 1, H3g///histone cluster 1, H3i///histone cluster 1, H3e///histone cluster 1, H3c///histone cluster 1, H3d///histone cluster 1, H3a",TRUE
+"214472_at",0.943294768503521,0.745340286114311,0.328872551599299,-5.88714098189297,0.28043614926785,"HIST1H3F///HIST1H3B///HIST1H3H///HIST1H3J///HIST1H3G///HIST1H3I///HIST1H3E///HIST1H3C///HIST1H3D///HIST1H3A///HIST1H2AD","histone cluster 1, H3f///histone cluster 1, H3b///histone cluster 1, H3h///histone cluster 1, H3j///histone cluster 1, H3g///histone cluster 1, H3i///histone cluster 1, H3e///histone cluster 1, H3c///histone cluster 1, H3d///histone cluster 1, H3a///histone cluster 1, H2ad",TRUE
+"208496_x_at",0.740476003158683,0.229211885968646,-1.23652273704956,-5.22120507694412,-1.4148801285802,"HIST1H3G","histone cluster 1, H3g",TRUE
+"214509_at",0.686108994812404,0.154847036675895,1.47288371908048,-4.93492250709626,1.11997130954266,"HIST1H3I","histone cluster 1, H3i",TRUE
+"208046_at",0.827793155763086,0.3967631732808,-0.86415258063523,-5.58236600003644,-0.55563860053229,"HIST1H4A","histone cluster 1, H4a",TRUE
+"208076_at",0.961212424803935,0.823640855554454,-0.225521408611724,-5.9149418123145,-0.0785025274601896,"HIST1H4D","histone cluster 1, H4d",TRUE
+"206951_at",0.977874971442423,0.893242061248266,-0.135753393128878,-5.93071138656374,-0.0562864185528413,"HIST1H4E","histone cluster 1, H4e",TRUE
+"208551_at",0.620754085170559,0.0904194885102575,1.7704044764995,-4.51850026997949,0.636218873280128,"HIST1H4G","histone cluster 1, H4g",TRUE
+"208026_at",0.916057757219214,0.645984917696167,-0.465686747066876,-5.8346053986555,-0.205412484352268,"HIST1H4G///HIST1H4F","histone cluster 1, H4g///histone cluster 1, H4f",TRUE
+"208180_s_at",0.71454754703986,0.18975364516676,-1.35283323727229,-5.08554934621513,-1.28534494675674,"HIST1H4H","histone cluster 1, H4h",TRUE
+"232035_at",0.774230543658252,0.287135836620933,-1.09067404228515,-5.37632401219702,-0.94517700620338,"HIST1H4H","histone cluster 1, H4h",TRUE
+"214634_at",0.696090594363684,0.166116689567224,1.43194421484831,-4.98746907908586,1.12195598220096,"HIST1H4I","histone cluster 1, H4i",TRUE
+"214463_x_at",0.80056683899707,0.336480997251251,-0.98245866674088,-5.48018488288481,-0.56863341029724,"HIST1H4J","histone cluster 1, H4j",TRUE
+"214562_at",0.984802091612958,0.92550682895928,0.0945694862056745,-5.935328424929,0.0686887065545729,"HIST1H4L","histone cluster 1, H4l",TRUE
+"234392_at",0.567292616148537,0.057223619702151,2.0059397517152,-4.1495330244859,1.35219257368147,"HIST1H4PS1","histone cluster 1, H4, pseudogene 1",TRUE
+"214290_s_at",0.533225267583674,0.0421097621148989,-2.15705005798642,-3.896656371364,-1.94393495803387,"HIST2H2AA4///HIST2H2AA3","histone cluster 2, H2aa4///histone cluster 2, H2aa3",TRUE
+"218280_x_at",0.62110896023334,0.0917336369010306,-1.76274470180737,-4.5299448105897,-1.45875463315607,"HIST2H2AA4///HIST2H2AA3","histone cluster 2, H2aa4///histone cluster 2, H2aa3",TRUE
+"218279_s_at",0.939166148226364,0.727690514670454,0.352640409842529,-5.8792954591952,0.117563595531153,"HIST2H2AA4///HIST2H2AA3","histone cluster 2, H2aa4///histone cluster 2, H2aa3",TRUE
+"202708_s_at",0.668518995965071,0.1346343196617,-1.55281978688468,-4.8288999365168,-1.66203358147116,"HIST2H2BE","histone cluster 2, H2be",TRUE
+"208580_x_at",0.817845908536187,0.370457645556602,-0.914192384526935,-5.5406189085246,-0.57124815725876,"HIST2H4B///HIST4H4///HIST2H4A///HIST1H4L///HIST1H4E///HIST1H4B///HIST1H4H///HIST1H4C///HIST1H4J///HIST1H4K///HIST1H4F///HIST1H4D///HIST1H4A///HIST1H4I","histone cluster 2, H4b///histone cluster 4, H4///histone cluster 2, H4a///histone cluster 1, H4l///histone cluster 1, H4e///histone cluster 1, H4b///histone cluster 1, H4h///histone cluster 1, H4c///histone cluster 1, H4j///histone cluster 1, H4k///histone cluster 1, H4f///histone cluster 1, H4d///histone cluster 1, H4a///histone cluster 1, H4i",TRUE
+"207046_at",0.931582451098271,0.697849509850146,-0.393310045125172,-5.8646179081277,-0.371586095727928,"HIST2H4B///HIST4H4///HIST2H4A///HIST1H4L///HIST1H4E///HIST1H4B///HIST1H4H///HIST1H4C///HIST1H4J///HIST1H4K///HIST1H4F///HIST1H4D///HIST1H4A///HIST1H4I","histone cluster 2, H4b///histone cluster 4, H4///histone cluster 2, H4a///histone cluster 1, H4l///histone cluster 1, H4e///histone cluster 1, H4b///histone cluster 1, H4h///histone cluster 1, H4c///histone cluster 1, H4j///histone cluster 1, H4k///histone cluster 1, H4f///histone cluster 1, H4d///histone cluster 1, H4a///histone cluster 1, H4i",TRUE
+"205967_at",0.945498722604777,0.753747585511734,0.317619386532335,-5.89066663868314,0.106692582689668,"HIST2H4B///HIST4H4///HIST2H4A///HIST1H4L///HIST1H4E///HIST1H4B///HIST1H4H///HIST1H4C///HIST1H4J///HIST1H4K///HIST1H4F///HIST1H4D///HIST1H4A///HIST1H4I","histone cluster 2, H4b///histone cluster 4, H4///histone cluster 2, H4a///histone cluster 1, H4l///histone cluster 1, H4e///histone cluster 1, H4b///histone cluster 1, H4h///histone cluster 1, H4c///histone cluster 1, H4j///histone cluster 1, H4k///histone cluster 1, H4f///histone cluster 1, H4d///histone cluster 1, H4a///histone cluster 1, H4i",TRUE
+"208181_at",0.94895689004559,0.767870678094461,-0.298808586261709,-5.89628860862422,-0.260931837637737,"HIST2H4B///HIST4H4///HIST2H4A///HIST1H4L///HIST1H4E///HIST1H4B///HIST1H4H///HIST1H4C///HIST1H4J///HIST1H4K///HIST1H4F///HIST1H4D///HIST1H4A///HIST1H4I","histone cluster 2, H4b///histone cluster 4, H4///histone cluster 2, H4a///histone cluster 1, H4l///histone cluster 1, H4e///histone cluster 1, H4b///histone cluster 1, H4h///histone cluster 1, H4c///histone cluster 1, H4j///histone cluster 1, H4k///histone cluster 1, H4f///histone cluster 1, H4d///histone cluster 1, H4a///histone cluster 1, H4i",TRUE
+"214516_at",0.969882914559333,0.856688049378996,0.182708720450485,-5.92343717476158,0.120972970851071,"HIST2H4B///HIST4H4///HIST2H4A///HIST1H4L///HIST1H4E///HIST1H4B///HIST1H4H///HIST1H4C///HIST1H4J///HIST1H4K///HIST1H4F///HIST1H4D///HIST1H4A///HIST1H4I","histone cluster 2, H4b///histone cluster 4, H4///histone cluster 2, H4a///histone cluster 1, H4l///histone cluster 1, H4e///histone cluster 1, H4b///histone cluster 1, H4h///histone cluster 1, H4c///histone cluster 1, H4j///histone cluster 1, H4k///histone cluster 1, H4f///histone cluster 1, H4d///histone cluster 1, H4a///histone cluster 1, H4i",TRUE
+"231681_x_at",0.886783047600321,0.550093829476301,-0.606888516460997,-5.76186628594932,-0.240778006735503,"HIST3H2A","histone cluster 3, H2a",TRUE
+"221582_at",0.92051722798026,0.661938127353495,-0.443172215308763,-5.84447360430143,-0.399634254779919,"HIST3H2A","histone cluster 3, H2a",TRUE
+"208572_at",0.878278790222455,0.530734285716044,-0.636871476763809,-5.74403584197426,-0.523304914943505,"HIST3H3","histone cluster 3, H3",TRUE
+"204512_at",0.637485146909712,0.10855329589311,1.67217803152876,-4.66245505968605,0.4601172846788,"HIVEP1","human immunodeficiency virus type I enhancer binding protein 1",TRUE
+"1560485_at",0.929088231432081,0.687399198004875,0.407710098592164,-5.85904290206505,0.171337113264534,"HIVEP1","human immunodeficiency virus type I enhancer binding protein 1",TRUE
+"243254_at",0.812302873476553,0.360065889769554,0.934606560626933,-5.52296528041992,0.679775531355681,"HIVEP2","human immunodeficiency virus type I enhancer binding protein 2",TRUE
+"212641_at",0.892746695408886,0.565664251983674,0.583175664052371,-5.77538017199396,0.319563743642032,"HIVEP2","human immunodeficiency virus type I enhancer binding protein 2",TRUE
+"212642_s_at",0.951518251175176,0.777849394641988,-0.285584202490199,-5.90003730849686,-0.140990874417627,"HIVEP2","human immunodeficiency virus type I enhancer binding protein 2",TRUE
+"220042_x_at",0.700511129947842,0.172325097353424,1.41033785871848,-5.01471273759948,0.831397478594715,"HIVEP3","human immunodeficiency virus type I enhancer binding protein 3",TRUE
+"244764_at",0.712975827977365,0.18738556848216,-1.36039435539193,-5.07637532375283,-0.605125007786524,"HIVEP3","human immunodeficiency virus type I enhancer binding protein 3",TRUE
+"235122_at",0.743553048228796,0.234316018663973,-1.22262987607436,-5.2367105968339,-1.53935159368766,"HIVEP3","human immunodeficiency virus type I enhancer binding protein 3",TRUE
+"232581_x_at",0.833668762114382,0.411254343678369,0.83750077192614,-5.6037089413474,0.415464406484067,"HIVEP3","human immunodeficiency virus type I enhancer binding protein 3",TRUE
+"233884_at",0.979588787486838,0.901970691726975,-0.124591161078746,-5.93212564760331,-0.0852310228628612,"HIVEP3","human immunodeficiency virus type I enhancer binding protein 3",TRUE
+"218726_at",0.837067957688307,0.419347097580213,0.822876049983358,-5.61515506107687,0.256188147394489,"HJURP","Holliday junction recognition protein",TRUE
+"200697_at",0.754518597760932,0.247973382408161,-1.18654813685673,-5.27627080791736,-0.499070015085431,"HK1","hexokinase 1",TRUE
+"202934_at",0.781969078550387,0.303562756145075,-1.05328321489838,-5.41331303105612,-0.564520862971188,"HK2","hexokinase 2",TRUE
+"239410_at",0.883789607966855,0.542009132962718,0.619339968428457,-5.7545621439772,0.357969235237986,"HK2","hexokinase 2",TRUE
+"222305_at",0.973108874852577,0.870838441298302,0.164487906692738,-5.92651395417072,0.111859975931013,"HK2","hexokinase 2",TRUE
+"205936_s_at",0.646392036827936,0.117432320106299,1.62908145235321,-4.72365059348828,0.443261531241891,"HK3","hexokinase 3",TRUE
+"227614_at",0.412444326023181,0.0164903577000262,2.59450869739331,-3.10458983787332,2.95309618372674,"HKDC1","hexokinase domain containing 1",TRUE
+"237323_at",0.501591596209182,0.0322405420367627,2.28502221615099,-3.67360032344529,1.94437677088605,"HKDC1","hexokinase domain containing 1",TRUE
+"220585_at",0.651040858265466,0.120813178746437,1.61338944867893,-4.74562753040097,1.88482840299973,"HKDC1","hexokinase domain containing 1",TRUE
+"237324_s_at",0.997171203405,0.98579747984902,0.0180031476342577,-5.93952561833155,0.0150570804539614,"HKDC1","hexokinase domain containing 1",TRUE
+"231836_at",0.538220959971034,0.043795977154296,-2.13796676424797,-3.9292389452994,-0.793090989368602,"HKR1","HKR1, GLI-Kruppel zinc finger family member",TRUE
+"1569980_x_at",0.767011398042819,0.26828658315275,-1.13553289075888,-5.33043465653477,-0.797281770942992,"HKR1","HKR1, GLI-Kruppel zinc finger family member",TRUE
+"1569979_at",0.975398143273847,0.882068714324649,-0.150067969471183,-5.92872057553093,-0.0432326427373297,"HKR1","HKR1, GLI-Kruppel zinc finger family member",TRUE
+"215313_x_at",0.520899183693116,0.0378038950323601,2.20911315238745,-3.8068525313886,1.65503579811243,"HLA-A","major histocompatibility complex, class I, A",TRUE
+"213932_x_at",0.544229585370526,0.0465015696905867,2.10868878849871,-3.97887164831576,1.7594986135087,"HLA-A","major histocompatibility complex, class I, A",TRUE
+"211911_x_at",0.48580305784244,0.0284820968742864,2.3434184979413,-3.56929685894753,1.81057109298508,"HLA-B","major histocompatibility complex, class I, B",TRUE
+"208729_x_at",0.51470556386048,0.0350988957859468,2.24464836362834,-3.7448088422056,1.74402926152498,"HLA-B","major histocompatibility complex, class I, B",TRUE
+"209140_x_at",0.602822122207901,0.077357873302164,1.85226617324042,-4.39394827685581,1.43759973952922,"HLA-B","major histocompatibility complex, class I, B",TRUE
+"214459_x_at",0.571677937624457,0.0593981019776893,1.98722368851072,-4.1800111760162,1.17896407904529,"HLA-C","major histocompatibility complex, class I, C",TRUE
+"211799_x_at",0.578441573439199,0.0617427530423624,1.96771158303335,-4.21158041252197,1.69167147199929,"HLA-C","major histocompatibility complex, class I, C",TRUE
+"208812_x_at",0.614178202960275,0.0851000851916132,1.80242308697465,-4.47026897945027,0.977139152345838,"HLA-C","major histocompatibility complex, class I, C",TRUE
+"216526_x_at",0.696440263939453,0.166378329435491,1.43102069531423,-4.98864049786783,0.956745909720734,"HLA-C","major histocompatibility complex, class I, C",TRUE
+"217478_s_at",0.768882610729436,0.27426909933002,1.12105315758361,-5.34542606377618,0.783081128623696,"HLA-DMA","major histocompatibility complex, class II, DM alpha",TRUE
+"203932_at",0.95773836044529,0.81015819242057,-0.243108112695674,-5.91093822032779,-0.0990329332425954,"HLA-DMB","major histocompatibility complex, class II, DM beta",TRUE
+"211142_x_at",0.670452734752167,0.136199698672013,-1.5462891988145,-4.83772878215485,-0.778883642574816,"HLA-DOA","major histocompatibility complex, class II, DO alpha",TRUE
+"217001_x_at",0.740370450344979,0.228956261077877,1.23722467274397,-5.22041765281421,0.53616361727491,"HLA-DOA","major histocompatibility complex, class II, DO alpha",TRUE
+"216946_at",0.832792886465252,0.409778564633117,0.840187293903568,-5.60158582940718,0.515980819696806,"HLA-DOA","major histocompatibility complex, class II, DO alpha",TRUE
+"226878_at",0.851319596585235,0.454807653911868,-0.760782777026563,-5.66164075926507,-0.443852825485629,"HLA-DOA","major histocompatibility complex, class II, DO alpha",TRUE
+"206313_at",0.929125618312698,0.688104891622465,-0.406734953236174,-5.85942665993645,-0.233614106665949,"HLA-DOA","major histocompatibility complex, class II, DO alpha",TRUE
+"1554984_a_at",0.629621797906838,0.100654351552021,1.71309966161879,-4.603228663873,0.728037667073158,"HLA-DOB","major histocompatibility complex, class II, DO beta",TRUE
+"205671_s_at",0.638148730101617,0.109526980946933,1.66730992336146,-4.669428619548,1.44800620227475,"HLA-DOB","major histocompatibility complex, class II, DO beta",TRUE
+"213537_at",0.330171916405281,0.00794511290031316,2.91726188631143,-2.47439896789318,2.16388443397422,"HLA-DPA1","major histocompatibility complex, class II, DP alpha 1",TRUE
+"211990_at",0.743553048228796,0.234096382117535,1.22322295210746,-5.2360517693704,1.31383400581477,"HLA-DPA1","major histocompatibility complex, class II, DP alpha 1",TRUE
+"211991_s_at",0.85334340854827,0.460748903431337,-0.750671411594527,-5.66888473435056,-0.558311228748159,"HLA-DPA1","major histocompatibility complex, class II, DP alpha 1",TRUE
+"216631_s_at",0.784552021081681,0.308182032453677,-1.04302953855926,-5.42325431612059,-0.474466793173573,"HLA-DPA2","major histocompatibility complex, class II, DP alpha 2 (pseudogene)",TRUE
+"201137_s_at",0.597654932724127,0.074170963182821,1.87405256956904,-4.36012309150047,1.57155327508291,"HLA-DPB1","major histocompatibility complex, class II, DP beta 1",TRUE
+"244485_at",0.927151504869754,0.681641394518215,0.415681525710071,-5.85587193147807,0.146330860676268,"HLA-DPB1","major histocompatibility complex, class II, DP beta 1",TRUE
+"239975_at",0.809744885587232,0.353200316470003,-0.948311279949416,-5.51091291058956,-0.404902998298414,"HLA-DPB2","major histocompatibility complex, class II, DP beta 2 (pseudogene)",TRUE
+"203290_at",0.959356077764139,0.815737797078277,0.235820924524309,-5.91263340589779,0.115849354432174,"HLA-DQA1","major histocompatibility complex, class II, DQ alpha 1",TRUE
+"209480_at",0.857750641191636,0.47331509095977,-0.729538208815989,-5.68372825143559,-0.777250985103839,"HLA-DQB1","major histocompatibility complex, class II, DQ beta 1",TRUE
+"210747_at",0.954672574687803,0.793453107168639,-0.265008043855589,-5.90553516695085,-0.181043775690709,"HLA-DQB1","major histocompatibility complex, class II, DQ beta 1",TRUE
+"211654_x_at",0.967106491969364,0.846766378975408,-0.195521885786434,-5.92108077255923,-0.126593024528363,"HLA-DQB1","major histocompatibility complex, class II, DQ beta 1",TRUE
+"215536_at",0.668620158511127,0.134926675407812,-1.55159536758978,-4.83055749373675,-0.966827543119879,"HLA-DQB2","major histocompatibility complex, class II, DQ beta 2",TRUE
+"210982_s_at",0.890816525789205,0.559718984625352,-0.592189451785326,-5.77030456582556,-0.791763430965913,"HLA-DRA","major histocompatibility complex, class II, DR alpha",TRUE
+"208894_at",0.940778455596726,0.734917587445811,-0.342883898173795,-5.8825814516449,-0.417676084040875,"HLA-DRA","major histocompatibility complex, class II, DR alpha",TRUE
+"208306_x_at",0.871959063104412,0.51454754845909,-0.662398563848462,-5.72820417194817,-0.550842678551548,"HLA-DRB1","major histocompatibility complex, class II, DR beta 1",TRUE
+"215669_at",0.942502815705589,0.742276779991484,-0.332983766198655,-5.88582262819119,-0.269023446753793,"HLA-DRB4","major histocompatibility complex, class II, DR beta 4",TRUE
+"209728_at",0.954449231029359,0.790984604730257,0.268255181403873,-5.90469465941321,0.0784895712123759,"HLA-DRB4","major histocompatibility complex, class II, DR beta 4",TRUE
+"215666_at",0.966593471043185,0.844252177516317,0.198774045734215,-5.92045737303094,0.123474477756635,"HLA-DRB4","major histocompatibility complex, class II, DR beta 4",TRUE
+"217362_x_at",0.828607509614823,0.39918787781865,-0.859650157870365,-5.58601529192856,-0.590317167157587,"HLA-DRB6","major histocompatibility complex, class II, DR beta 6 (pseudogene)",TRUE
+"217323_at",0.991363846997029,0.959512601276838,-0.0513425881548095,-5.93839963401024,-0.0399561610398127,"HLA-DRB6","major histocompatibility complex, class II, DR beta 6 (pseudogene)",TRUE
+"217456_x_at",0.507573068809926,0.0333647482268473,2.2687670484154,-3.70236048125344,0.874771042995189,"HLA-E","major histocompatibility complex, class I, E",TRUE
+"200904_at",0.55937703282623,0.0537515265039786,2.03717804914853,-4.09823950071734,1.57905515442197,"HLA-E","major histocompatibility complex, class I, E",TRUE
+"200905_x_at",0.580630437263151,0.0633651159745064,1.95459045554752,-4.23269050252319,0.877107449859622,"HLA-E","major histocompatibility complex, class I, E",TRUE
+"221875_x_at",0.376502947045791,0.0115068390400277,2.75509749605106,-2.79513388301704,1.64559926100378,"HLA-F","major histocompatibility complex, class I, F",TRUE
+"204806_x_at",0.40221114169538,0.0145839412841447,2.64971128881475,-2.9992038903003,1.51547938607911,"HLA-F","major histocompatibility complex, class I, F",TRUE
+"221978_at",0.441966033306807,0.0204836200896104,2.49602323135222,-3.28983949720451,1.25689629122469,"HLA-F","major histocompatibility complex, class I, F",TRUE
+"222279_at",0.609322761685536,0.0816108017160161,1.82437788479383,-4.43683560193266,0.603416793284504,"HLA-F-AS1","HLA-F antisense RNA 1",TRUE
+"1562381_at",0.838350471423215,0.4233624243941,-0.815685701465244,-5.62071338186982,-0.7793096468502,"HLA-F-AS1","HLA-F antisense RNA 1",TRUE
+"211530_x_at",0.209119042035931,0.00242490119160092,3.42146497593523,-1.43662832375063,2.44672042905223,"HLA-G","major histocompatibility complex, class I, G",TRUE
+"210514_x_at",0.470885186348082,0.0254689932653879,2.39560219646518,-3.47482623518071,1.51421233247026,"HLA-G","major histocompatibility complex, class I, G",TRUE
+"211529_x_at",0.497725944448536,0.030762257492767,2.30720562770235,-3.63415741810995,1.91800145371991,"HLA-G","major histocompatibility complex, class I, G",TRUE
+"211528_x_at",0.51470556386048,0.0351773424275653,2.24358322565154,-3.74667721489007,1.58397547785611,"HLA-G","major histocompatibility complex, class I, G",TRUE
+"217436_x_at",0.463632028061434,0.0237796401286364,2.42741266649046,-3.41667273154299,1.57375551725751,"HLA-J","major histocompatibility complex, class I, J (pseudogene)",TRUE
+"209399_at",0.915766032166572,0.644783234821529,0.467392454837357,-5.83383826132469,0.177284498887086,"HLCS","holocarboxylase synthetase",TRUE
+"207833_s_at",0.95168059103032,0.778382929779501,0.284878613973093,-5.90023259130857,0.162860450806006,"HLCS","holocarboxylase synthetase",TRUE
+"204755_x_at",0.256999052540656,0.00376978948582728,-3.23622451213182,-1.82383018871903,-3.0693637334073,"HLF","HLF, PAR bZIP transcription factor",TRUE
+"204753_s_at",0.670002076145692,0.135687021023459,-1.54842117970105,-4.83484974194869,-1.77153700900221,"HLF","HLF, PAR bZIP transcription factor",TRUE
+"204754_at",0.775351898377291,0.292060979681824,-1.07930602173799,-5.38769185909951,-1.05797751066549,"HLF","HLF, PAR bZIP transcription factor",TRUE
+"202983_at",0.934048461921637,0.707876462591182,-0.379572523739857,-5.86975231205304,-0.155749895810928,"HLTF","helicase like transcription factor",TRUE
+"214438_at",0.965719307845066,0.839880863293544,0.204433658943888,-5.9193480689563,0.152388510285998,"HLX","H2.0 like homeobox",TRUE
+"230107_at",0.35403024587355,0.00944728173259276,2.8418012794084,-2.62460268629995,0.847071009794688,"HM13","histocompatibility minor 13",TRUE
+"232209_x_at",0.725925587053034,0.204971910615907,-1.30593314933486,-5.14149348112086,-0.34959000561564,"HM13","histocompatibility minor 13",TRUE
+"224615_x_at",0.7768734672127,0.294385416471325,1.07398865679977,-5.39297263494311,0.319927669458039,"HM13","histocompatibility minor 13",TRUE
+"1557148_at",0.831943055644609,0.407952591714049,-0.843519837780006,-5.59894335441613,-0.470419433398634,"HM13","histocompatibility minor 13",TRUE
+"1558561_at",0.927312359577901,0.68187775225368,0.415353762586535,-5.85600350359724,0.225479209178977,"HM13","histocompatibility minor 13",TRUE
+"229541_at",0.866090088397363,0.496859290583844,0.690809611471611,-5.70988346839224,0.239180354615485,"HMBOX1","homeobox containing 1",TRUE
+"219269_at",0.869971289491322,0.508123697459824,0.672652183011733,-5.72167708515037,0.354451704124834,"HMBOX1","homeobox containing 1",TRUE
+"225504_at",0.961212424803935,0.823085675573624,-0.22624410945663,-5.9147831806049,-0.0834992861998956,"HMBOX1","homeobox containing 1",TRUE
+"242850_at",0.974678827660841,0.876328519618685,-0.157434248751948,-5.9276185622726,-0.0715258961594545,"HMBOX1","homeobox containing 1",TRUE
+"203040_s_at",0.934048461921637,0.707912224116351,0.379523662771443,-5.86977025268896,0.161999956735913,"HMBS","hydroxymethylbilane synthase",TRUE
+"201678_s_at",0.79943091106207,0.334202746763899,-0.987201007231788,-5.47583905033123,-0.392952283726727,"HMCES","5-hydroxymethylcytosine (hmC) binding, ES cell-specific",TRUE
+"201677_at",0.813442508625161,0.363924681317123,-0.926980762266762,-5.52960184469409,-0.326283583027433,"HMCES","5-hydroxymethylcytosine (hmC) binding, ES cell-specific",TRUE
+"235944_at",0.719333457476224,0.195201832462168,1.33571534801752,-5.10616050118444,2.74875076908652,"HMCN1","hemicentin 1",TRUE
+"1564117_at",0.545412722791443,0.047067252662522,2.10276177059975,-3.98886618111341,1.0897248176462,"HMCN2","hemicentin 2",TRUE
+"235797_x_at",0.682744111897512,0.150739236139597,1.48840759204427,-4.91468394190045,0.645158016253222,"HMCN2","hemicentin 2",TRUE
+"235932_x_at",0.683019114815084,0.15177398781081,1.48446502839858,-4.9198400902491,0.532627891684962,"HMCN2","hemicentin 2",TRUE
+"1563532_at",0.841813886364358,0.433827871723607,-0.797142755799471,-5.63483622870603,-0.538552245396722,"HMCN2","hemicentin 2",TRUE
+"241650_x_at",0.932249295738588,0.700946384968705,-0.389059037755188,-5.86622594438853,-0.200366553109012,"HMCN2","hemicentin 2",TRUE
+"218152_at",0.720952283360079,0.197037677883894,-1.33003166498476,-5.1129553228347,-0.421897752452436,"HMG20A","high mobility group 20A",TRUE
+"209113_s_at",0.280199223932988,0.00460453676995388,-3.15147428683361,-1.9989002723874,-1.14470771209052,"HMG20B","high mobility group 20B",TRUE
+"210719_s_at",0.407748633394319,0.0156861086003918,-2.6170248454062,-3.06173494268891,-0.959051864192892,"HMG20B","high mobility group 20B",TRUE
+"213966_at",0.854116828440652,0.463595358163615,0.745854690598769,-5.67230325190609,0.571060540322175,"HMG20B","high mobility group 20B",TRUE
+"206074_s_at",0.188695940369035,0.00187746852420219,3.52798478726156,-1.21159276990462,1.76326571986529,"HMGA1","high mobility group AT-hook 1",TRUE
+"210457_x_at",0.189245182004241,0.00188985586418501,3.52525416399761,-1.21738025355153,2.62961167418579,"HMGA1","high mobility group AT-hook 1",TRUE
+"208025_s_at",0.165626734753013,0.00135106581984168,3.66418670031598,-0.921825791282859,4.84957410757814,"HMGA2","high mobility group AT-hook 2",TRUE
+"1561633_at",0.451798866010908,0.0216582501657904,2.47046674141884,-3.33730325721781,2.97795033190619,"HMGA2","high mobility group AT-hook 2",TRUE
+"1559891_at",0.612283891684441,0.0838887724299615,1.80995498260442,-4.45883213147441,0.961555910884932,"HMGA2","high mobility group AT-hook 2",TRUE
+"1567224_at",0.635368778245437,0.106379419516763,1.68318139821183,-4.64663597450924,1.56676585012032,"HMGA2","high mobility group AT-hook 2",TRUE
+"1568286_at",0.649592174485584,0.120140394483735,1.61648256496853,-4.74130856742808,1.52651819178535,"HMGA2","high mobility group AT-hook 2",TRUE
+"1558683_a_at",0.695812999227098,0.165832915313692,1.43294718542168,-4.98619618202576,1.21562843670757,"HMGA2","high mobility group AT-hook 2",TRUE
+"1558682_at",0.821424121108148,0.383114669237436,0.88983487498751,-5.56121165081379,0.873234134017567,"HMGA2","high mobility group AT-hook 2",TRUE
+"1567223_at",0.896115372949367,0.577367161376253,0.565573119093837,-5.78507469199212,0.401624840370426,"HMGA2","high mobility group AT-hook 2",TRUE
+"1568287_at",0.934447550624693,0.709391954904727,0.377502729772397,-5.87051029779414,0.352160776241952,"HMGA2","high mobility group AT-hook 2",TRUE
+"224731_at",0.835952408568777,0.417069529023699,0.826973786758759,-5.61196697046987,0.187457903183798,"HMGB1","high mobility group box 1",TRUE
+"200679_x_at",0.89203601623083,0.562370177292373,0.588163830588281,-5.77258067158739,0.18757708168984,"HMGB1","high mobility group box 1",TRUE
+"200680_x_at",0.937409179150458,0.722198247477171,0.360078292463697,-5.87672919532248,0.0795893074837544,"HMGB1","high mobility group box 1",TRUE
+"214938_x_at",0.980264692225439,0.907921555980089,0.116990527391222,-5.93301935107963,0.0255339560222119,"HMGB1","high mobility group box 1",TRUE
+"224734_at",0.980326742949294,0.908301639585283,-0.116505317086784,-5.93307449646743,-0.0551201704269886,"HMGB1","high mobility group box 1",TRUE
+"208808_s_at",0.823074246722209,0.389631404678079,-0.877499458539772,-5.57144402053219,-0.286322344933193,"HMGB2","high mobility group box 2",TRUE
+"236091_at",0.997890350692744,0.99018701404534,0.0124385968476081,-5.93960812325983,0.00617802851919524,"HMGB2","high mobility group box 2",TRUE
+"225601_at",0.560994261493672,0.05457573803173,-2.02960341186531,-4.1107253582261,-1.15118819946603,"HMGB3","high mobility group box 3",TRUE
+"203744_at",0.865345395265289,0.494797637806324,-0.694158049620732,-5.70767581975542,-0.310105425955401,"HMGB3","high mobility group box 3",TRUE
+"216548_x_at",0.950887541143339,0.775701620668957,0.288426088709202,-5.89924591892036,0.113051158141291,"HMGB3P1","high mobility group box 3 pseudogene 1",TRUE
+"230473_s_at",0.985868869736215,0.931485898477756,0.0869581227337204,-5.93600111913591,0.0601661678577226,"HMGB4","high mobility group box 4",TRUE
+"202772_at",0.824712704091522,0.392166540350718,0.872737042151553,-5.57535903318205,0.340258555607404,"HMGCL","3-hydroxymethyl-3-methylglutaryl-CoA lyase",TRUE
+"233576_at",0.731631029652938,0.21538797641939,-1.27537273895362,-5.17704722229003,-1.77083315347516,"HMGCLL1","3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1",TRUE
+"1554872_a_at",0.870980161749509,0.510998456380603,0.668054658588942,-5.7246155804226,0.450795398038538,"HMGCLL1","3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1",TRUE
+"232305_at",0.886783047600321,0.550155845774005,0.606793378845562,-5.76192154372962,0.497069002371115,"HMGCLL1","3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1",TRUE
+"202540_s_at",0.703181475205533,0.175013133807811,-1.40117585780144,-5.02616228678701,-0.44623366585691,"HMGCR","3-hydroxy-3-methylglutaryl-CoA reductase",TRUE
+"202539_s_at",0.71454754703986,0.189609211253551,-1.35329227005529,-5.08499361300135,-0.46092682232292,"HMGCR","3-hydroxy-3-methylglutaryl-CoA reductase",TRUE
+"205822_s_at",0.907111393934291,0.615664046118289,0.509173721552016,-5.81419136560168,0.229690491417848,"HMGCS1","3-hydroxy-3-methylglutaryl-CoA synthase 1",TRUE
+"221750_at",0.979950968379024,0.904261294131843,0.121664665703111,-5.93247640135272,0.0480877265268536,"HMGCS1","3-hydroxy-3-methylglutaryl-CoA synthase 1",TRUE
+"240110_at",0.87579870142401,0.523588535598885,0.648087142647221,-5.73715355050143,0.203542220292991,"HMGCS2","3-hydroxy-3-methylglutaryl-CoA synthase 2",TRUE
+"204607_at",0.948684674264832,0.766728619499436,-0.300325539474899,-5.89584784417916,-0.343653764862515,"HMGCS2","3-hydroxy-3-methylglutaryl-CoA synthase 2",TRUE
+"200943_at",0.955892698633978,0.799095093409252,-0.257597272030587,-5.9074153279632,-0.0855520673270327,"HMGN1","high mobility group nucleosome binding domain 1",TRUE
+"208668_x_at",0.979803152416153,0.903787485220984,0.122269918335994,-5.93240454188058,0.0258493008105809,"HMGN2","high mobility group nucleosomal binding domain 2",TRUE
+"242649_x_at",0.641209837140528,0.111660241717421,1.65677075365648,-4.6844729555111,1.84102584794963,"HMGN2P46","high mobility group nucleosomal binding domain 2 pseudogene 46",TRUE
+"209377_s_at",0.734614760371776,0.219237596186158,1.26436650074145,-5.18967596267688,0.49091388813472,"HMGN3","high mobility group nucleosomal binding domain 3",TRUE
+"1559403_at",0.732366036474569,0.21674284108267,-1.27148199954401,-5.18152220648768,-0.776481548612154,"HMGN3-AS1","HMGN3 antisense RNA 1",TRUE
+"1559404_a_at",0.783969326139111,0.307063614435648,1.04550211439302,-5.42086507021916,0.531240995089339,"HMGN3-AS1","HMGN3 antisense RNA 1",TRUE
+"202579_x_at",0.544577979658206,0.0466780277867293,2.1068330020201,-3.98200293387642,0.75210869585271,"HMGN4","high mobility group nucleosomal binding domain 4",TRUE
+"209786_at",0.581406183553129,0.0638653272030528,1.95060474552697,-4.23908388129075,0.791031988470051,"HMGN4","high mobility group nucleosomal binding domain 4",TRUE
+"209787_s_at",0.627861734840005,0.0992291403887058,1.72077212119728,-4.59200464689775,0.715087463375674,"HMGN4","high mobility group nucleosomal binding domain 4",TRUE
+"221238_at",0.863918945062466,0.490192216719171,0.701666890637315,-5.70268815962302,0.386484497610561,"HMGN5","high mobility group nucleosome binding domain 5",TRUE
+"221606_s_at",0.982723176827697,0.916038412415243,-0.106634697996823,-5.93414662313809,-0.10526060979069,"HMGN5","high mobility group nucleosome binding domain 5",TRUE
+"212431_at",0.899423459651693,0.590194350770811,-0.546484504177193,-5.79526190778303,-0.157821536992758,"HMGXB3","HMG-box containing 3",TRUE
+"34221_at",0.969946179106301,0.857777221781913,-0.181304072451146,-5.92368581789131,-0.0514955003677233,"HMGXB3","HMG-box containing 3",TRUE
+"212596_s_at",0.902424542997102,0.60139895506205,-0.529977152118934,-5.80379748313624,-0.208377720609292,"HMGXB4","HMG-box containing 4",TRUE
+"212597_s_at",0.918041148686074,0.651839693766262,-0.457396196347374,-5.83829491951402,-0.158134816501914,"HMGXB4","HMG-box containing 4",TRUE
+"208302_at",0.979347742195592,0.900202871680773,0.126850505568931,-5.93184916094092,0.037636019542064,"HMHB1","histocompatibility minor HB-1",TRUE
+"209709_s_at",0.657571067962164,0.126247596976445,1.58891857654098,-4.7795700934321,0.666575525272323,"HMMR","hyaluronan mediated motility receptor",TRUE
+"207165_at",0.683017520100356,0.151462754168344,1.48564856966492,-4.91829339267216,0.640733730537184,"HMMR","hyaluronan mediated motility receptor",TRUE
+"1557029_at",0.812302873476553,0.357536260436249,-0.939635443625884,-5.51856142202386,-0.648969497856454,"HMMR-AS1","HMMR antisense RNA 1",TRUE
+"203665_at",0.812302873476553,0.359395588304443,-0.935936797109573,-5.52180248642148,-0.584279551035706,"HMOX1","heme oxygenase 1",TRUE
+"218120_s_at",0.788120945317721,0.314297011279517,-1.02962150094983,-5.43612173460207,-0.319303087371566,"HMOX2","heme oxygenase 2",TRUE
+"218121_at",0.831392326632573,0.405671138315337,0.847697048606934,-5.59561733040863,0.320779126659072,"HMOX2","heme oxygenase 2",TRUE
+"218623_at",0.888830748858811,0.555963350298183,0.59790904714061,-5.76704487406648,0.496309090186617,"HMP19","HMP19 protein",TRUE
+"207353_s_at",0.677013732819214,0.143983306681071,-1.51470587241842,-4.88001006698415,-1.05641848566452,"HMX1","H6 family homeobox 1",TRUE
+"244565_at",0.871906834215372,0.5144688866689,-0.66252368936982,-5.72812510050875,-0.425527989787008,"HMX2","H6 family homeobox 2",TRUE
+"217755_at",0.967777603239069,0.848424851409041,-0.193377807697407,-5.92148616214542,-0.0878477322430076,"HN1","hematological and neurological expressed 1",TRUE
+"222396_at",0.997674669021782,0.988731069617759,0.0142842236553198,-5.93958410134155,0.00710363257477553,"HN1","hematological and neurological expressed 1",TRUE
+"216031_x_at",0.885029460971826,0.545329510060816,0.614214335140556,-5.7575862112526,0.167817071462242,"HN1L","hematological and neurological expressed 1 like",TRUE
+"212109_at",0.887462893068143,0.552004181483594,0.603960479323627,-5.7635631154866,0.147044952567731,"HN1L","hematological and neurological expressed 1 like",TRUE
+"212115_at",0.966641191718519,0.845092802270603,-0.197686441799669,-5.92066699368115,-0.0738298080446746,"HN1L","hematological and neurological expressed 1 like",TRUE
+"1557443_s_at",0.955892698633978,0.79957746723734,-0.256964361526883,-5.90757344595874,-0.138117384380122,"HNCAT21","head and neck cancer-associated transcript 21",TRUE
+"216930_at",0.592306976560844,0.0693651864822878,1.90850510770532,-4.30606577272687,0.880225428971272,"HNF1A","HNF1 homeobox A",TRUE
+"210515_at",0.901788521024914,0.59964722722806,0.532547988232223,-5.8024849027512,0.203863461478994,"HNF1A","HNF1 homeobox A",TRUE
+"208135_at",0.875938621758472,0.52411350737209,-0.647260334374603,-5.73766484689774,-0.29787221289713,"HNF1B","HNF1 homeobox B",TRUE
+"205313_at",0.991367768700244,0.959782491746622,0.0510000252835849,-5.93841670769424,0.0369820520839834,"HNF1B","HNF1 homeobox B",TRUE
+"230772_at",0.723649742218726,0.200098403655214,1.32064723606051,-5.12412097503392,0.423410713626575,"HNF4A","hepatocyte nuclear factor 4 alpha",TRUE
+"216889_s_at",0.78226567430527,0.304430463514204,1.05134871759124,-5.41519527919288,0.704367845033626,"HNF4A","hepatocyte nuclear factor 4 alpha",TRUE
+"214832_at",0.794090864301234,0.325833877460282,1.00481548595793,-5.45953087347709,0.254302766202937,"HNF4A","hepatocyte nuclear factor 4 alpha",TRUE
+"230914_at",0.796378050779806,0.328866570040249,-0.998396591870838,-5.46550406605239,-0.509355435349254,"HNF4A","hepatocyte nuclear factor 4 alpha",TRUE
+"208429_x_at",0.908709061737317,0.620430143752361,0.502273976976777,-5.81754902506727,0.182847749740596,"HNF4A","hepatocyte nuclear factor 4 alpha",TRUE
+"214851_at",0.943464796017993,0.746732405249663,-0.327006245610037,-5.88773410605948,-0.194405891469387,"HNF4A","hepatocyte nuclear factor 4 alpha",TRUE
+"1563265_at",0.942502815705589,0.742518666115183,0.332658943892218,-5.88592737939156,0.268318227127581,"HNF4A-AS1","HNF4A antisense RNA 1",TRUE
+"232271_at",0.864894115958506,0.493422279382642,0.696396274104645,-5.70619446133275,0.968755744662784,"HNF4G","hepatocyte nuclear factor 4 gamma",TRUE
+"207456_at",0.871393333367959,0.512109933018368,0.666280979938519,-5.72574406276911,0.58457206428781,"HNF4G","hepatocyte nuclear factor 4 gamma",TRUE
+"228772_at",0.724317760087277,0.201597621539933,1.31609134954407,-5.12951755463404,1.57221535454898,"HNMT","histamine N-methyltransferase",TRUE
+"1554303_at",0.784918343662568,0.30953939883275,-1.04003720768813,-5.4261389918688,-0.584205231784268,"HNMT","histamine N-methyltransferase",TRUE
+"204110_at",0.820288124919738,0.378556304871085,0.89854515446317,-5.5539067042671,0.415161480024898,"HNMT","histamine N-methyltransferase",TRUE
+"211732_x_at",0.831957210365167,0.408234583877165,0.843004561058595,-5.59935257118854,1.21667143128677,"HNMT","histamine N-methyltransferase",TRUE
+"204112_s_at",0.896159990898752,0.578928650673539,0.563238167655238,-5.78633902340283,0.996493013721919,"HNMT","histamine N-methyltransferase",TRUE
+"204111_at",0.949769006419463,0.772617761289775,0.292510834289129,-5.89809481060567,0.210330509455591,"HNMT","histamine N-methyltransferase",TRUE
+"201054_at",0.761748280722165,0.261216616648557,-1.15295362781656,-5.31217363958092,-0.4008841584142,"HNRNPA0","heterogeneous nuclear ribonucleoprotein A0",TRUE
+"229083_at",0.919560496803564,0.658316176788022,-0.448263024990192,-5.84228422677596,-0.167445771929726,"HNRNPA0","heterogeneous nuclear ribonucleoprotein A0",TRUE
+"201055_s_at",0.950887541143339,0.775663960689066,-0.288475941121942,-5.89923196697084,-0.106355230034895,"HNRNPA0","heterogeneous nuclear ribonucleoprotein A0",TRUE
+"221919_at",0.633326968581968,0.104564763602787,-1.69251334010991,-4.63315838717554,-0.764250891449695,"HNRNPA1","heterogeneous nuclear ribonucleoprotein A1",TRUE
+"222040_at",0.725168361556674,0.203443323687765,-1.3105186684519,-5.13609713670935,-0.578745171881277,"HNRNPA1","heterogeneous nuclear ribonucleoprotein A1",TRUE
+"214280_x_at",0.771623843789204,0.281072175452538,-1.10486488157429,-5.36198462347615,-0.37417196672685,"HNRNPA1","heterogeneous nuclear ribonucleoprotein A1",TRUE
+"200016_x_at",0.917184972563924,0.649972545897792,-0.460036576683021,-5.83712692485881,-0.0953618636828093,"HNRNPA1P10///HNRNPA1","heterogeneous nuclear ribonucleoprotein A1 pseudogene 10///heterogeneous nuclear ribonucleoprotein A1",TRUE
+"213356_x_at",0.968451827985008,0.851609090966098,-0.189263802744479,-5.92225154117345,-0.0479717684370566,"HNRNPA1P33///HNRNPA1P10///HNRNPA1L2///HNRNPA1","heterogeneous nuclear ribonucleoprotein A1 pseudogene 33///heterogeneous nuclear ribonucleoprotein A1 pseudogene 10///heterogeneous nuclear ribonucleoprotein A1-like 2///heterogeneous nuclear ribonucleoprotein A1",TRUE
+"225107_at",0.905462783815257,0.611748267109101,-0.514861267529447,-5.8113900155867,-0.277565652734717,"HNRNPA2B1","heterogeneous nuclear ribonucleoprotein A2/B1",TRUE
+"205292_s_at",0.957571530817866,0.808756806936087,-0.24494047903874,-5.91050389446727,-0.0495791656454347,"HNRNPA2B1","heterogeneous nuclear ribonucleoprotein A2/B1",TRUE
+"244131_at",0.971094654049796,0.861504201613009,0.176500388547461,-5.92452168222347,0.119396203847137,"HNRNPA2B1","heterogeneous nuclear ribonucleoprotein A2/B1",TRUE
+"225932_s_at",0.983364220761052,0.91890971746398,-0.102974283498347,-5.93452012732155,-0.0392326961359188,"HNRNPA2B1","heterogeneous nuclear ribonucleoprotein A2/B1",TRUE
+"211930_at",0.955645941042265,0.796927082266854,0.260443196783198,-5.90669956386598,0.117444952304963,"HNRNPA3","heterogeneous nuclear ribonucleoprotein A3",TRUE
+"211929_at",0.98539961718117,0.928196116860959,-0.0911453383939381,-5.93563802696811,-0.034894901547661,"HNRNPA3","heterogeneous nuclear ribonucleoprotein A3",TRUE
+"211932_at",0.999369827418759,0.998093031692778,-0.0024171434648053,-5.93968063504297,-0.000753338874362797,"HNRNPA3","heterogeneous nuclear ribonucleoprotein A3",TRUE
+"211931_s_at",0.929672814693557,0.689904797135371,0.404249611102349,-5.86040064909988,0.127185093246931,"HNRNPA3///HNRNPA3P1","heterogeneous nuclear ribonucleoprotein A3///heterogeneous nuclear ribonucleoprotein A3 pseudogene 1",TRUE
+"206809_s_at",0.958833323462396,0.813793025217362,-0.238359372436539,-5.91204872120254,-0.0869870822286636,"HNRNPA3///HNRNPA3P1","heterogeneous nuclear ribonucleoprotein A3///heterogeneous nuclear ribonucleoprotein A3 pseudogene 1",TRUE
+"211933_s_at",0.989524702314661,0.9488873725785,0.0648342655916025,-5.93763632702494,0.0159745472408925,"HNRNPA3///HNRNPA3P1","heterogeneous nuclear ribonucleoprotein A3///heterogeneous nuclear ribonucleoprotein A3 pseudogene 1",TRUE
+"206808_at",0.722585632346351,0.199178565433779,-1.32345567739791,-5.12078645882172,-0.838211128992848,"HNRNPA3P1","heterogeneous nuclear ribonucleoprotein A3 pseudogene 1",TRUE
+"201277_s_at",0.668049477824787,0.134208604744901,-1.55460666314919,-4.82647910226935,-0.368591800763799,"HNRNPAB","heterogeneous nuclear ribonucleoprotein A/B",TRUE
+"235500_at",0.77496126434543,0.291416618105936,1.08078543292702,-5.38621848600446,0.760994736034072,"HNRNPC","heterogeneous nuclear ribonucleoprotein C (C1/C2)",TRUE
+"1568941_a_at",0.821424121108148,0.383149353388515,-0.889768860554507,-5.56126676282219,-0.76384595402764,"HNRNPC","heterogeneous nuclear ribonucleoprotein C (C1/C2)",TRUE
+"212626_x_at",0.839425347843955,0.425212588851027,-0.812386932125367,-5.62324810868156,-0.222939940738861,"HNRNPC","heterogeneous nuclear ribonucleoprotein C (C1/C2)",TRUE
+"200014_s_at",0.851733415458562,0.456127004168619,-0.758530567657838,-5.66326222232078,-0.169128687729424,"HNRNPC","heterogeneous nuclear ribonucleoprotein C (C1/C2)",TRUE
+"227110_at",0.874834820370747,0.521506270386427,0.651371110652464,-5.73511656474676,0.240874529173638,"HNRNPC","heterogeneous nuclear ribonucleoprotein C (C1/C2)",TRUE
+"214737_x_at",0.898647305933017,0.588311531865835,-0.549273404736369,-5.79379470828484,-0.136741318591673,"HNRNPC","heterogeneous nuclear ribonucleoprotein C (C1/C2)",TRUE
+"200751_s_at",0.998347572104896,0.993180909789164,-0.00864351914149983,-5.93964709212204,-0.00260870424553694,"HNRNPC","heterogeneous nuclear ribonucleoprotein C (C1/C2)",TRUE
+"216302_at",0.988173753615796,0.943647773339883,-0.0714917743703792,-5.93719437172767,-0.043854455371994,"HNRNPCL4///HNRNPCL3///HNRNPCL2///HNRNPCL1","heterogeneous nuclear ribonucleoprotein C-like 4///heterogeneous nuclear ribonucleoprotein C-like 3///heterogeneous nuclear ribonucleoprotein C-like 2///heterogeneous nuclear ribonucleoprotein C-like 1",TRUE
+"227744_s_at",0.73223722457785,0.216247699441264,1.27290171299147,-5.17989065733183,0.619104860485644,"HNRNPD","heterogeneous nuclear ribonucleoprotein D",TRUE
+"229129_at",0.792611633508961,0.32423505798009,-1.00821621090917,-5.45635221620566,-0.446087689884386,"HNRNPD","heterogeneous nuclear ribonucleoprotein D",TRUE
+"213359_at",0.83030603167465,0.402208677127263,0.854065385525559,-5.59051718187016,0.483423798802827,"HNRNPD","heterogeneous nuclear ribonucleoprotein D",TRUE
+"209330_s_at",0.895213601869362,0.573129098455583,0.571926543730513,-5.78160876783582,0.162547451501325,"HNRNPD","heterogeneous nuclear ribonucleoprotein D",TRUE
+"200073_s_at",0.895690630367785,0.576246418426548,-0.567250966327175,-5.78416303854728,-0.154727446036794,"HNRNPD","heterogeneous nuclear ribonucleoprotein D",TRUE
+"239040_at",0.899808883319249,0.592024831066895,0.543777325436452,-5.79667917373673,0.521595109053437,"HNRNPD","heterogeneous nuclear ribonucleoprotein D",TRUE
+"221480_at",0.921312278448293,0.664945151460896,-0.438954738394626,-5.84626880712222,-0.261674543593783,"HNRNPD","heterogeneous nuclear ribonucleoprotein D",TRUE
+"205183_at",0.954723352940649,0.793850466987339,0.264485618409375,-5.90566944509671,0.191456513621221,"HNRNPD","heterogeneous nuclear ribonucleoprotein D",TRUE
+"221481_x_at",0.982925605058683,0.917340565468792,-0.104974497476047,-5.93431764280111,-0.0280590490269272,"HNRNPD","heterogeneous nuclear ribonucleoprotein D",TRUE
+"209068_at",0.813488170855271,0.364139176836066,-0.926558463977976,-5.52996790017025,-0.33483439874319,"HNRNPDL","heterogeneous nuclear ribonucleoprotein D like",TRUE
+"1554678_s_at",0.943464796017993,0.747156687110244,-0.326437679656003,-5.88791413609938,-0.106059392074695,"HNRNPDL","heterogeneous nuclear ribonucleoprotein D like",TRUE
+"214379_at",0.947778780715578,0.762072704123758,-0.306517309077467,-5.89402582607909,-0.0878625808939599,"HNRNPDL","heterogeneous nuclear ribonucleoprotein D like",TRUE
+"212454_x_at",0.952369155692131,0.781961703471992,0.280149560388947,-5.90152905865334,0.0977484825786057,"HNRNPDL","heterogeneous nuclear ribonucleoprotein D like",TRUE
+"209067_s_at",0.990810941805126,0.95589858411013,-0.0559303617273479,-5.93815996210531,-0.0167004990016508,"HNRNPDL","heterogeneous nuclear ribonucleoprotein D like",TRUE
+"201993_x_at",0.998870448604467,0.995907478121296,0.00518742171885541,-5.93967037420823,0.00165391060660269,"HNRNPDL","heterogeneous nuclear ribonucleoprotein D like",TRUE
+"201376_s_at",0.941158863404109,0.736257293987256,-0.341079051662272,-5.88317933443053,-0.126214933082052,"HNRNPF","heterogeneous nuclear ribonucleoprotein F",TRUE
+"201031_s_at",0.738726167317415,0.225448282173908,-1.24691826417245,-5.20950416286249,-0.316916114830882,"HNRNPH1","heterogeneous nuclear ribonucleoprotein H1 (H)",TRUE
+"213470_s_at",0.923758661165355,0.672599033660513,-0.428256033236103,-5.85074718312137,-0.271652502008273,"HNRNPH1","heterogeneous nuclear ribonucleoprotein H1 (H)",TRUE
+"213619_at",0.929024902913511,0.687153413913224,-0.408049823692371,-5.85890899452975,-0.121026368012393,"HNRNPH1","heterogeneous nuclear ribonucleoprotein H1 (H)",TRUE
+"213472_at",0.938726197187622,0.726950586744321,-0.353641264214513,-5.87895321941375,-0.209484074389313,"HNRNPH1","heterogeneous nuclear ribonucleoprotein H1 (H)",TRUE
+"207127_s_at",0.713330901550199,0.187796713873336,1.35907621097597,-5.07797772213493,0.450585298665187,"HNRNPH3","heterogeneous nuclear ribonucleoprotein H3",TRUE
+"210588_x_at",0.789661545166663,0.3172096705451,1.02329951259353,-5.44213671492038,0.393326831936722,"HNRNPH3","heterogeneous nuclear ribonucleoprotein H3",TRUE
+"210110_x_at",0.864894115958506,0.4937963268713,0.695787205556788,-5.7065980212032,0.301377398430931,"HNRNPH3","heterogeneous nuclear ribonucleoprotein H3",TRUE
+"208990_s_at",0.97979222603145,0.90348820683527,-0.122652246406448,-5.93235896593281,-0.0433327626744155,"HNRNPH3","heterogeneous nuclear ribonucleoprotein H3",TRUE
+"200097_s_at",0.961561244483099,0.826019360418513,0.222426594693517,-5.91561540660563,0.0476134151972154,"HNRNPK","heterogeneous nuclear ribonucleoprotein K",TRUE
+"200775_s_at",0.961644868810744,0.826170965965847,-0.222229407332247,-5.91565801104749,-0.0449195962839521,"HNRNPK","heterogeneous nuclear ribonucleoprotein K",TRUE
+"202072_at",0.746259710622309,0.237750152847282,1.21341104997812,-5.24691591698628,1.06348845935453,"HNRNPL","heterogeneous nuclear ribonucleoprotein L",TRUE
+"35201_at",0.749589620061359,0.242512161669366,1.20079241345055,-5.26077626761118,0.571739682260748,"HNRNPL","heterogeneous nuclear ribonucleoprotein L",TRUE
+"1554453_at",0.84325576065163,0.437675573402322,0.790395028900591,-5.63989972797867,0.303857938367782,"HNRNPLL","heterogeneous nuclear ribonucleoprotein L like",TRUE
+"225386_s_at",0.9133270451231,0.63668124367301,0.478929817399084,-5.82857729070046,0.228022306907105,"HNRNPLL","heterogeneous nuclear ribonucleoprotein L like",TRUE
+"236104_at",0.943966108617097,0.748905677064176,-0.324095072663841,-5.88865262530918,-0.125750460724925,"HNRNPLL","heterogeneous nuclear ribonucleoprotein L like",TRUE
+"225385_s_at",0.965992617204023,0.840978267182641,0.203012196961135,-5.91962959747589,0.108703173825941,"HNRNPLL","heterogeneous nuclear ribonucleoprotein L like",TRUE
+"214918_at",0.734577729521114,0.219097217965995,1.26476522974976,-5.18922008817308,0.543702841802459,"HNRNPM","heterogeneous nuclear ribonucleoprotein M",TRUE
+"1555843_at",0.762690194692501,0.262181293264665,1.15055629983999,-5.31470111553797,0.321876859805359,"HNRNPM","heterogeneous nuclear ribonucleoprotein M",TRUE
+"1555844_s_at",0.837839105061376,0.422555033616675,-0.817128072469173,-5.61960205855667,-0.192576021877748,"HNRNPM","heterogeneous nuclear ribonucleoprotein M",TRUE
+"234035_at",0.922908550456534,0.669834110696743,0.432114956898552,-5.84914438627723,0.231082689524032,"HNRNPM","heterogeneous nuclear ribonucleoprotein M",TRUE
+"233605_x_at",0.926806145687218,0.680980032751579,0.416598898724061,-5.85550313293911,0.130210089788198,"HNRNPM","heterogeneous nuclear ribonucleoprotein M",TRUE
+"200072_s_at",0.940044918888428,0.730708381948605,-0.348562116004229,-5.8806801116536,-0.101207973443925,"HNRNPM","heterogeneous nuclear ribonucleoprotein M",TRUE
+"1556084_at",0.981944022360435,0.913588222588086,-0.109759442485747,-5.93381746831487,-0.0383798563186248,"HNRNPM","heterogeneous nuclear ribonucleoprotein M",TRUE
+"232004_at",0.867447813467579,0.499864979615363,0.685942058870016,-5.71307449651384,0.306466505662145,"HNRNPR","heterogeneous nuclear ribonucleoprotein R",TRUE
+"208765_s_at",0.956960361976289,0.804949879049402,-0.249922536219664,-5.90930660558423,-0.0927696585854534,"HNRNPR","heterogeneous nuclear ribonucleoprotein R",TRUE
+"208766_s_at",0.957208446914964,0.80631076130477,-0.248140838504678,-5.90973753625127,-0.0497751982044718,"HNRNPR","heterogeneous nuclear ribonucleoprotein R",TRUE
+"225805_at",0.714846001190098,0.190651749233727,-1.34998508303905,-5.0889939711074,-0.619854205299525,"HNRNPU","heterogeneous nuclear ribonucleoprotein U",TRUE
+"200594_x_at",0.766353407604609,0.266636321405807,-1.13956870065226,-5.32622597701388,-0.249092217592143,"HNRNPU","heterogeneous nuclear ribonucleoprotein U",TRUE
+"200593_s_at",0.937462538530338,0.722612163870928,-0.35951703126595,-5.87692469057035,-0.106373701131018,"HNRNPU","heterogeneous nuclear ribonucleoprotein U",TRUE
+"216855_s_at",0.952743383622821,0.783797863262199,0.277725764215905,-5.90218519254222,0.127368336649743,"HNRNPU","heterogeneous nuclear ribonucleoprotein U",TRUE
+"235603_at",0.977858230085336,0.892600251518561,-0.136574823623186,-5.93060252846023,-0.0822548368802662,"HNRNPU","heterogeneous nuclear ribonucleoprotein U",TRUE
+"208713_at",0.48580305784244,0.0284528598809894,-2.34389990410432,-3.5684307212762,-0.780079556754274,"HNRNPUL1","heterogeneous nuclear ribonucleoprotein U like 1",TRUE
+"209675_s_at",0.816800680706682,0.368306568076796,-0.918386451478447,-5.53702129894352,-0.338029332440202,"HNRNPUL1","heterogeneous nuclear ribonucleoprotein U like 1",TRUE
+"222264_at",0.862800800218883,0.486583388156939,0.707579228467468,-5.69872495774233,0.207163770851942,"HNRNPUL2","heterogeneous nuclear ribonucleoprotein U like 2",TRUE
+"225405_at",0.942477426470706,0.741457066273986,-0.334084809476594,-5.88546680278715,-0.119275533046849,"HNRNPUL2","heterogeneous nuclear ribonucleoprotein U like 2",TRUE
+"208906_at",0.296964617886988,0.00539240251432636,-3.08415379194527,-2.13689707462358,-1.50612489888212,"HNRNPUL2-BSCL2///BSCL2","HNRNPUL2-BSCL2 readthrough (NMD candidate)///BSCL2, seipin lipid droplet biogenesis associated",TRUE
+"66053_at",0.999188340279058,0.997403105835405,0.00329164946978761,-5.93967820344278,0.00146380020244319,"HNRNPUL2-BSCL2///HNRNPUL2","HNRNPUL2-BSCL2 readthrough (NMD candidate)///heterogeneous nuclear ribonucleoprotein U like 2",TRUE
+"239093_at",0.684804162148888,0.153305952349381,1.47866797575014,-4.92740154771785,0.810090558131398,"HOGA1","4-hydroxy-2-oxoglutarate aldolase 1",TRUE
+"226651_at",0.976422537443518,0.88806406103875,0.142383318538801,-5.92981406663409,0.0908606247032999,"HOMER1","homer scaffolding protein 1",TRUE
+"213793_s_at",0.979588787486838,0.902481449437358,0.123938516553876,-5.93220459123086,0.102943044983519,"HOMER1","homer scaffolding protein 1",TRUE
+"1556097_at",0.73759219552868,0.224426001091272,1.24976476320305,-5.20628553735744,1.12139270811266,"HOMER2","homer scaffolding protein 2",TRUE
+"217080_s_at",0.991689960875868,0.961557600030973,-0.0487470940872824,-5.93852614904787,-0.0332574280933162,"HOMER2","homer scaffolding protein 2",TRUE
+"215489_x_at",0.731548533938014,0.215218246947427,1.27586147448188,-5.17648427184878,0.700916606141385,"HOMER3","homer scaffolding protein 3",TRUE
+"204647_at",0.753294178355034,0.246537650251211,1.19026993423017,-5.27223787558949,0.675456690679942,"HOMER3","homer scaffolding protein 3",TRUE
+"222222_s_at",0.803583569469174,0.341999954195642,0.97106128339593,-5.490551330197,0.926796410176322,"HOMER3","homer scaffolding protein 3",TRUE
+"231868_at",0.843424227955276,0.438040033325032,0.78975777148513,-5.64037583286576,0.313538005573411,"HOMEZ","homeobox and leucine zipper encoding",TRUE
+"219976_at",0.90343137006939,0.603659532646273,0.526664859285394,-5.80547951165799,0.325720221864973,"HOOK1","hook microtubule tethering protein 1",TRUE
+"225792_at",0.90985106339387,0.624822640644712,0.49593689737165,-5.82059347919914,0.595984635194013,"HOOK1","hook microtubule tethering protein 1",TRUE
+"218780_at",0.729789891627758,0.212057336680653,1.28501805347058,-5.16590327511414,0.783526840932806,"HOOK2","hook microtubule tethering protein 2",TRUE
+"224359_s_at",0.727074488271062,0.207300699216712,-1.29899795187224,-5.14962453808851,-0.67606492542567,"HOOK3","hook microtubule tethering protein 3",TRUE
+"235114_x_at",0.885029460971826,0.545500657762654,-0.61395058613705,-5.75774116483593,-0.303296175770676,"HOOK3","hook microtubule tethering protein 3",TRUE
+"236192_at",0.893600768892136,0.568720100450555,-0.578561559493976,-5.77794919342876,-0.419672633857888,"HOOK3","hook microtubule tethering protein 3",TRUE
+"1558315_s_at",0.968451827985008,0.851568085728316,0.189316759698499,-5.92224179313794,0.0843217896302662,"HOOK3","hook microtubule tethering protein 3",TRUE
+"226395_at",0.97689149311934,0.889845624054862,-0.140101478311702,-5.93012771867905,-0.107860833321553,"HOOK3","hook microtubule tethering protein 3",TRUE
+"1566139_at",0.380084968057051,0.0117346251329052,2.74643180917275,-2.81205064587976,1.41761937201827,"HOPX","HOP homeobox",TRUE
+"1566140_at",0.789224993491684,0.31545824196329,-1.02709611599195,-5.43852849322617,-0.69562987906215,"HOPX","HOP homeobox",TRUE
+"211597_s_at",0.968980656821882,0.853448228861947,-0.186889181915227,-5.9226858554669,-0.254458471086075,"HOPX","HOP homeobox",TRUE
+"223861_at",0.0550194051692779,0.000100117533498316,4.72861048100798,1.37094925001705,4.83870709832313,"HORMAD1","HORMA domain containing 1",TRUE
+"244442_at",0.94118897722809,0.73675133524992,0.34041377328283,-5.88339893096094,0.201818021216272,"HORMAD2","HORMA domain containing 2",TRUE
+"237781_at",0.998038817582822,0.990827123813177,0.0116271766064744,-5.93961763429708,0.00717812115205874,"HORMAD2","HORMA domain containing 2",TRUE
+"239153_at",0.847527520228882,0.446324105960743,-0.775359842862149,-5.65103628901403,-1.073352077704,"HOTAIR","HOX transcript antisense RNA",TRUE
+"228642_at",0.142607803108174,0.000969835384345408,3.80071129424055,-0.629566503073962,3.00285622630073,"HOTAIRM1","HOXA transcript antisense RNA, myeloid-specific 1",TRUE
+"1557050_at",0.150704524202907,0.00108876610992498,3.75314526681965,-0.731565977675945,2.54056100966948,"HOTAIRM1","HOXA transcript antisense RNA, myeloid-specific 1",TRUE
+"1557051_s_at",0.190498595861526,0.00194063538035198,3.51424085624643,-1.24071316403018,2.83480700042466,"HOTAIRM1","HOXA transcript antisense RNA, myeloid-specific 1",TRUE
+"229148_at",0.612254398413001,0.0838063450886676,1.81047092267082,-4.4580474376239,0.641907270279231,"HOTAIRM1///HOXA2","HOXA transcript antisense RNA, myeloid-specific 1///homeobox A2",TRUE
+"229149_at",0.780614263830306,0.302118251137183,1.05651237563347,-5.4101641675746,0.452476053357675,"HOTAIRM1///HOXA2","HOXA transcript antisense RNA, myeloid-specific 1///homeobox A2",TRUE
+"224348_s_at",0.858572126489256,0.474299268559332,0.727897141498288,-5.68486406866102,0.689864302340661,"HOTS","H19 opposite tumor suppressor",TRUE
+"244553_at",0.628084912651991,0.0995116296939703,1.71924394400474,-4.59424320041103,1.01676539329292,"HOTTIP","HOXA distal transcript antisense RNA",TRUE
+"1564070_s_at",0.911458797509096,0.629760932665773,0.488836879996008,-5.82395961638738,0.184013715428019,"HOTTIP","HOXA distal transcript antisense RNA",TRUE
+"1564069_at",0.960588243569671,0.820825579727355,-0.229187446703308,-5.91413190606752,-0.0691695200148228,"HOTTIP","HOXA distal transcript antisense RNA",TRUE
+"1562640_at",0.671655467883069,0.137787234170714,1.53972910827978,-4.84656788093593,1.46424374410056,"HOXA-AS2","HOXA cluster antisense RNA 2",TRUE
+"242528_at",0.768852835478002,0.27415481258219,1.12132759527984,-5.34514350976261,0.687395993237018,"HOXA-AS2","HOXA cluster antisense RNA 2",TRUE
+"230080_at",0.896139457361073,0.578641847526962,0.563666797262195,-5.78610730879143,0.601188485505758,"HOXA-AS2","HOXA cluster antisense RNA 2",TRUE
+"239915_at",0.499428826990278,0.0314864637964845,2.29621883475394,-3.65372013561974,1.78224749256917,"HOXA-AS3","HOXA cluster antisense RNA 3",TRUE
+"214639_s_at",0.125055451060988,0.000739676988404416,3.91186774451855,-0.390611792461562,5.0304622949845,"HOXA1","homeobox A1",TRUE
+"213147_at",0.407748633394319,0.0156929517796955,2.6168287298096,-3.06210898980346,3.12997324161028,"HOXA10","homeobox A10",TRUE
+"213150_at",0.53908164396154,0.0441223659209491,2.13434973217977,-3.93539407953073,2.92159667879807,"HOXA10","homeobox A10",TRUE
+"231365_at",0.868397087637799,0.50424292854986,0.678881798737954,-5.71766467243446,0.777266247671431,"HOXA10-AS///MIR196B","HOXA10 antisense RNA///microRNA 196b",TRUE
+"214651_s_at",0.536186589417525,0.043090898019425,2.14586418752042,-3.91577703038439,3.56168971504467,"HOXA10-HOXA9///MIR196B///HOXA9","HOXA10-HOXA9 readthrough///microRNA 196b///homeobox A9",TRUE
+"209905_at",0.752913428584105,0.246026497045283,1.19159889539013,-5.27079514984799,1.90177080895416,"HOXA10-HOXA9///MIR196B///HOXA9","HOXA10-HOXA9 readthrough///microRNA 196b///homeobox A9",TRUE
+"213823_at",0.50789985308763,0.0334233867656021,2.26793299092038,-3.70383290236684,2.5780627217763,"HOXA11","homeobox A11",TRUE
+"208493_at",0.603702127972549,0.0780029131543153,1.84795194600049,-4.40061316177603,1.84864361035758,"HOXA11","homeobox A11",TRUE
+"239950_at",0.593339168375633,0.0702847077790228,1.90175469357947,-4.31671164274728,1.3533893532156,"HOXA11-AS","HOXA11 antisense RNA",TRUE
+"230666_at",0.687217870448485,0.155811319810195,1.46928813432715,-4.93958564168128,0.566404007968739,"HOXA11-AS","HOXA11 antisense RNA",TRUE
+"238571_at",0.54295328972902,0.0457221758026121,2.11696209959709,-3.96489061930653,0.844909642852928,"HOXA13","homeobox A13",TRUE
+"231786_at",0.606192735863141,0.079872198795758,1.83562249261803,-4.41959933819521,2.33537940194204,"HOXA13","homeobox A13",TRUE
+"238808_at",0.882420879090034,0.5400500115288,0.622372096197127,-5.75276182215111,0.715580132152846,"HOXA13","homeobox A13",TRUE
+"214457_at",0.6181505942496,0.0891020862247793,1.77817988285337,-4.50684577867604,1.89614140862375,"HOXA2","homeobox A2",TRUE
+"235521_at",0.405851918322614,0.0151905046206742,2.63144635469643,-3.03419186831842,3.01510056342568,"HOXA3","homeobox A3",TRUE
+"208604_s_at",0.481888240234054,0.0273753063405024,2.36196805095777,-3.53584986776626,1.71862110428525,"HOXA3","homeobox A3",TRUE
+"206289_at",0.255716413540338,0.00370459035712602,3.24359180792155,-1.80854499678014,2.84909555549851,"HOXA4","homeobox A4",TRUE
+"213844_at",0.756304764390261,0.251243958584734,1.17812969160158,-5.28535236282057,1.40810766801389,"HOXA5","homeobox A5",TRUE
+"208557_at",0.741143136625128,0.2313766533561,1.23060210393998,-5.22783145201109,0.781588045054216,"HOXA6","homeobox A6",TRUE
+"235753_at",0.369429132228615,0.0110203733820736,2.77416203011794,-2.75783396792009,2.48113556416417,"HOXA7","homeobox A7",TRUE
+"206847_s_at",0.61760967235709,0.0882756147389302,1.78310843046433,-4.49943908862471,1.59914645197181,"HOXA7","homeobox A7",TRUE
+"244512_at",0.809257484080097,0.352461791831721,0.949796156783181,-5.50959740270916,0.493711604686778,"HOXB-AS1","HOXB cluster antisense RNA 1",TRUE
+"237189_at",0.896118635245982,0.578277867546884,0.564210921957478,-5.78581291198784,0.532171373037117,"HOXB-AS1","HOXB cluster antisense RNA 1",TRUE
+"236892_s_at",0.62932992642067,0.100215990907338,-1.71544961564527,-4.59979490616374,-1.89076151555479,"HOXB-AS3","HOXB cluster antisense RNA 3",TRUE
+"240151_at",0.708894565317004,0.181457827431795,-1.37965768580894,-5.05281036866189,-1.00014437420266,"HOXB-AS3","HOXB cluster antisense RNA 3",TRUE
+"230743_at",0.91876780831279,0.654423132406179,0.453748323247722,-5.83989774676313,0.157111551706146,"HOXB-AS3","HOXB cluster antisense RNA 3",TRUE
+"236893_at",0.945819521856653,0.755237671970781,-0.315629306889313,-5.89127749058762,-0.237248623200664,"HOXB-AS3","HOXB cluster antisense RNA 3",TRUE
+"239791_at",0.994825233837873,0.975842603250737,-0.030625246206985,-5.93922667178536,-0.033814853359289,"HOXB-AS3","HOXB cluster antisense RNA 3",TRUE
+"243811_at",0.709158363400091,0.181904413680794,1.3781892045364,-5.0546164714683,1.10515245713379,"HOXB1","homeobox B1",TRUE
+"208224_at",0.7468442753788,0.238839911385429,1.21050665691546,-5.25011724551032,0.63783910243399,"HOXB1","homeobox B1",TRUE
+"230105_at",0.971460432573208,0.864106725511345,0.173148535275545,-5.92509166670398,0.107545755697381,"HOXB13","homeobox B13",TRUE
+"209844_at",0.995111934465262,0.977335820786702,-0.0287316753809891,-5.93928141366718,-0.0340935610019555,"HOXB13","homeobox B13",TRUE
+"205453_at",0.95442332217412,0.790429170082598,-0.268986220768748,-5.90450403111865,-0.422834738341995,"HOXB2","homeobox B2",TRUE
+"208414_s_at",0.801086839730802,0.337282523151525,0.980795486713532,-5.48170449095835,0.617842283887452,"HOXB3","homeobox B3",TRUE
+"228904_at",0.957430653957785,0.807769985297203,0.246231301088698,-5.91019598421753,0.237801023078793,"HOXB3","homeobox B3",TRUE
+"231767_at",0.975398143273847,0.881992196785073,-0.150166106115437,-5.92870624029162,-0.0680897516994721,"HOXB4","homeobox B4",TRUE
+"205601_s_at",0.726696341943087,0.206482799869064,1.30142675779193,-5.14678110004975,0.666182308658109,"HOXB5","homeobox B5",TRUE
+"205600_x_at",0.743323328391634,0.233558665462843,1.22467670834301,-5.23443567433347,0.522143741754731,"HOXB5","homeobox B5",TRUE
+"205365_at",0.728385463227073,0.208692107061555,1.29488309092994,-5.15443157965651,0.660435346335674,"HOXB6","homeobox B6",TRUE
+"205366_s_at",0.859276375962637,0.47617061328506,0.724782272145616,-5.68701325057313,0.862660713518764,"HOXB6","homeobox B6",TRUE
+"204778_x_at",0.919958860702745,0.65930159790411,0.446876786286721,-5.84288282946942,0.426340727655235,"HOXB7","homeobox B7",TRUE
+"204779_s_at",0.954014881715784,0.788797373614253,0.271134789745966,-5.90394078100136,0.374873463561654,"HOXB7","homeobox B7",TRUE
+"216973_s_at",0.959357995170594,0.816057936550211,0.235403209073215,-5.91272902235613,0.270837719022198,"HOXB7","homeobox B7",TRUE
+"229667_s_at",0.623503825356688,0.094516852918798,1.74682820546335,-4.5536089063565,1.07205726579004,"HOXB8","homeobox B8",TRUE
+"221278_at",0.899808883319249,0.593250084118092,0.541967539116651,-5.79762282064217,0.264511693211045,"HOXB8","homeobox B8",TRUE
+"226461_at",0.695005304830231,0.164628511752379,1.43721944530379,-4.98076598039257,0.675308094487357,"HOXB9","homeobox B9",TRUE
+"216417_x_at",0.927395026557689,0.68207423517033,-0.415081330081456,-5.85611278697563,-0.180212634999726,"HOXB9","homeobox B9",TRUE
+"1561273_at",0.854369428184955,0.465289512457891,-0.74299623192802,-5.67432209411287,-0.276452723733034,"HOXC-AS3","HOXC cluster antisense RNA 3",TRUE
+"218959_at",0.888756025960104,0.555538458049153,-0.59855739648495,-5.76667345881247,-0.660210949009082,"HOXC10","homeobox C10",TRUE
+"206745_at",0.56861088242915,0.0580276534663292,-1.9989469174539,-4.16094291588707,-1.31378804853558,"HOXC11","homeobox C11",TRUE
+"1553512_at",0.71454754703986,0.189511977365951,1.35360144913285,-5.08461921301881,0.956564353473924,"HOXC12","homeobox C12",TRUE
+"219832_s_at",0.955925931146022,0.800984630701284,0.255118669558524,-5.90803234216399,0.214766193529071,"HOXC13","homeobox C13",TRUE
+"206194_at",0.82153774281298,0.384005296813739,-0.888140979083149,-5.56262459796622,-0.625533448787172,"HOXC4","homeobox C4",TRUE
+"206739_at",0.615821255316333,0.0864268056215085,-1.79427913657368,-4.48259629863432,-1.45910451845402,"HOXC5","homeobox C5",TRUE
+"206858_s_at",0.484495305292367,0.0278024059803229,-2.35472951589048,-3.54891956074311,-1.58630420892376,"HOXC6","homeobox C6",TRUE
+"221350_at",0.914242258486146,0.639542793234139,0.474847469554919,-5.83045316799668,0.232056324118487,"HOXC8","homeobox C8",TRUE
+"231936_at",0.837609393049242,0.421902138645252,-0.818295705402325,-5.6187010684492,-0.644124395796939,"HOXC9","homeobox C9",TRUE
+"229493_at",0.628993469581459,0.0999832143417003,-1.71670104038538,-4.5979648857047,-1.30375732604802,"HOXD-AS2","HOXD cluster antisense RNA 2",TRUE
+"205974_at",0.776954388941225,0.29547087635944,1.07151586973358,-5.39542046428847,0.688396165076319,"HOXD1","homeobox D1",TRUE
+"205975_s_at",0.835838027302116,0.415277279707835,0.830208274964685,-5.60944003188762,0.465476529894915,"HOXD1","homeobox D1",TRUE
+"238847_at",0.356547077571111,0.0096191686410022,2.83390918816005,-2.64021820219396,1.98478267814819,"HOXD10","homeobox D10",TRUE
+"229400_at",0.606900628956089,0.0804489211379051,1.83186913718514,-4.42536109925292,1.59294973381727,"HOXD10","homeobox D10",TRUE
+"207373_at",0.622434989367596,0.0930026322656505,1.75543700830581,-4.54082928266512,1.05137443791896,"HOXD10","homeobox D10",TRUE
+"214604_at",0.863835356219448,0.489782129739652,0.702337470165252,-5.70224024565084,0.659304928708058,"HOXD11","homeobox D11",TRUE
+"221411_at",0.743553048228796,0.234180295335005,1.22299631478977,-5.23630356546037,0.321113949364052,"HOXD12","homeobox D12",TRUE
+"207397_s_at",0.627092759817312,0.0983957474368446,1.72530222994883,-4.58535999210574,1.69140178625768,"HOXD13","homeobox D13",TRUE
+"207398_at",0.838596846474979,0.42366658410592,0.815142778782678,-5.62113121805269,0.675631229476869,"HOXD13","homeobox D13",TRUE
+"236681_at",0.974884920935236,0.877185656802277,0.156333744971539,-5.92778654726814,0.1059792945747,"HOXD13","homeobox D13",TRUE
+"1552337_s_at",0.812302873476553,0.357535495478623,0.939636967967636,-5.5185600838483,0.738700661050431,"HOXD4","homeobox D4",TRUE
+"205522_at",0.946050828306305,0.755767866095342,-0.314921522040373,-5.89149382734742,-0.207617520990893,"HOXD4","homeobox D4",TRUE
+"231906_at",0.905934790589647,0.612301604217753,-0.514056522722966,-5.81178822800662,-0.539700564418107,"HOXD8","homeobox D8",TRUE
+"205605_at",0.752235383514782,0.245516707624639,-1.19292637278882,-5.26935263527169,-0.722046576268131,"HOXD9","homeobox D9",TRUE
+"205604_at",0.912722788750542,0.634135908792351,0.482567995768896,-5.82689227825294,0.205494229035659,"HOXD9","homeobox D9",TRUE
+"206697_s_at",0.592605015502039,0.0697544236853705,1.90563810728586,-4.31059043996718,1.27823864641549,"HP","haptoglobin",TRUE
+"1563119_at",0.784925710185113,0.310006469078614,1.03900968905095,-5.42712782259567,0.631264523709377,"HP09025","uncharacterized LOC100652929",TRUE
+"1557908_at",0.805156059006033,0.344372646362251,-0.966200038427045,-5.49493927791506,-0.61658894367349,"HP11014","uncharacterized HP11014",TRUE
+"220633_s_at",0.660054711393139,0.127978783639299,1.58130747050217,-4.79004472303352,0.792229036339128,"HP1BP3","heterochromatin protein 1 binding protein 3",TRUE
+"229204_at",0.795219510513362,0.32730900529662,1.00168812605868,-5.46244542062997,0.317570129517943,"HP1BP3","heterochromatin protein 1 binding protein 3",TRUE
+"1554251_at",0.841526980254885,0.43263629337409,0.799239917171509,-5.63325427153026,0.415300232689203,"HP1BP3","heterochromatin protein 1 binding protein 3",TRUE
+"224591_at",0.877333806479767,0.526884924926891,0.642902962824581,-5.74034907699747,0.182403410792446,"HP1BP3","heterochromatin protein 1 binding protein 3",TRUE
+"224592_x_at",0.938152911190962,0.725933885939754,0.355017092965294,-5.87848119393073,0.111980272514055,"HP1BP3","heterochromatin protein 1 binding protein 3",TRUE
+"205454_at",0.787929163003677,0.313908487160588,-1.03046790692009,-5.43531389419882,-0.650899674519605,"HPCA","hippocalcin",TRUE
+"205462_s_at",0.920295529438727,0.660698079102618,0.444913811378473,-5.84372736603492,0.284673284449008,"HPCAL1","hippocalcin like 1",TRUE
+"212552_at",0.971216837324271,0.86264856409001,0.175026283901884,-5.9247736967646,0.110689137661522,"HPCAL1","hippocalcin like 1",TRUE
+"219671_at",0.689211402512415,0.158317167108951,1.46002804925218,-4.9515525886123,0.455497070648678,"HPCAL4","hippocalcin like 4",TRUE
+"222091_at",0.768852835478002,0.273953821609248,1.12181043925372,-5.34464623743165,0.639764080366326,"HPCAL4","hippocalcin like 4",TRUE
+"206024_at",0.931838763487749,0.698994114438465,0.391738018098364,-5.8652145679616,0.133022974677278,"HPD","4-hydroxyphenylpyruvate dioxygenase",TRUE
+"229332_at",0.592295755057089,0.0693530393027066,1.90859480694307,-4.30592413406695,1.96345171434689,"HPDL","4-hydroxyphenylpyruvate dioxygenase like",TRUE
+"1556086_at",0.724067243569133,0.201416002671907,1.31664185152222,-5.12886630522548,1.0864853593312,"HPF1","histone PARylation factor 1",TRUE
+"218646_at",0.882692407576314,0.54036758251462,-0.621880193715316,-5.75305446420845,-0.257765570658984,"HPF1","histone PARylation factor 1",TRUE
+"203913_s_at",0.917724754910316,0.650841835786877,0.458806880249273,-5.83767171112205,1.14028980053565,"HPGD","hydroxyprostaglandin dehydrogenase 15-(NAD)",TRUE
+"211549_s_at",0.957571530817866,0.809614250665158,0.243819236442665,-5.91077004766926,0.394364344312132,"HPGD","hydroxyprostaglandin dehydrogenase 15-(NAD)",TRUE
+"211548_s_at",0.972899347107693,0.868714149534478,0.167219472653835,-5.92607322015004,0.34122290657675,"HPGD","hydroxyprostaglandin dehydrogenase 15-(NAD)",TRUE
+"203914_x_at",0.980067566136987,0.90644615031886,-0.118874286791132,-5.93280308780122,-0.204732759311624,"HPGD","hydroxyprostaglandin dehydrogenase 15-(NAD)",TRUE
+"206726_at",0.773107052530371,0.283968692637875,1.0980587925953,-5.36888253314227,0.723340395331949,"HPGDS","hematopoietic prostaglandin D synthase",TRUE
+"204934_s_at",0.94895689004559,0.768773672928261,-0.297609679061883,-5.89663539637315,-0.168636347953468,"HPN","hepsin",TRUE
+"208471_at",0.68033297785336,0.147744504254361,1.49994361491718,-4.89953381835346,1.14101195582493,"HPR","haptoglobin-related protein",TRUE
+"208470_s_at",0.91671872326659,0.648073511364015,0.46272545896752,-5.83593070568737,0.176184553729121,"HPR///HP","haptoglobin-related protein///haptoglobin",TRUE
+"202854_at",0.922635094827638,0.669260923349504,0.43291577134105,-5.8488100001177,0.1467408937106,"HPRT1","hypoxanthine phosphoribosyltransferase 1",TRUE
+"1565446_at",0.937409179150458,0.72220530729955,0.360068718517907,-5.87673253258866,0.235043392316297,"HPRT1","hypoxanthine phosphoribosyltransferase 1",TRUE
+"203308_x_at",0.688182286445711,0.157561332633332,1.46280857433486,-4.94796571716932,0.874253384273285,"HPS1","HPS1, biogenesis of lysosomal organelles complex 3 subunit 1",TRUE
+"217354_s_at",0.751464513744428,0.244383642478877,1.1958842601147,-5.26613339419727,0.602002491597739,"HPS1","HPS1, biogenesis of lysosomal organelles complex 3 subunit 1",TRUE
+"203309_s_at",0.917887697142565,0.651270352559866,0.458200965259108,-5.83793962113223,0.16803468991482,"HPS1","HPS1, biogenesis of lysosomal organelles complex 3 subunit 1",TRUE
+"210112_at",0.947326616179611,0.760407851269642,0.308734308604672,-5.89336448327311,0.129117164803464,"HPS1","HPS1, biogenesis of lysosomal organelles complex 3 subunit 1",TRUE
+"239382_at",0.998377249856236,0.993264389683218,-0.00853770172641727,-5.93964797763491,-0.00512161420923363,"HPS1","HPS1, biogenesis of lysosomal organelles complex 3 subunit 1",TRUE
+"231121_at",0.879761308185056,0.534526137037598,-0.630953260767885,-5.7476208848233,-0.297677372219948,"HPS3","HPS3, biogenesis of lysosomal organelles complex 2 subunit 1",TRUE
+"227139_s_at",0.955730092376044,0.79722589165857,0.260050822856482,-5.90679871220409,0.0767310129044105,"HPS3","HPS3, biogenesis of lysosomal organelles complex 2 subunit 1",TRUE
+"238539_at",0.981944022360435,0.913661422030954,0.10966607465067,-5.93382744113018,0.0354202233476002,"HPS3","HPS3, biogenesis of lysosomal organelles complex 2 subunit 1",TRUE
+"1552652_at",0.500677386446044,0.0318797588386834,2.29034889099278,-3.6641496253036,0.629763447445717,"HPS4","HPS4, biogenesis of lysosomal organelles complex 3 subunit 2",TRUE
+"218402_s_at",0.758722841981575,0.255946481217126,-1.16616742924293,-5.29815962812502,-0.344320273188205,"HPS4","HPS4, biogenesis of lysosomal organelles complex 3 subunit 2",TRUE
+"54037_at",0.976371465776674,0.886724871717937,-0.14409907210259,-5.92957489549445,-0.0460103071942388,"HPS4","HPS4, biogenesis of lysosomal organelles complex 3 subunit 2",TRUE
+"204544_at",0.699391325858549,0.170962324098756,1.41502648084499,-5.00882971033598,0.730434842343131,"HPS5","HPS5, biogenesis of lysosomal organelles complex 2 subunit 2",TRUE
+"230371_at",0.835487689403823,0.414697511084751,-0.831256474357832,-5.60861914805353,-0.462379760734136,"HPS6","HPS6, biogenesis of lysosomal organelles complex 2 subunit 3",TRUE
+"219052_at",0.993026081687614,0.966780320174356,-0.0421199785956791,-5.93881942259718,-0.0138026444068231,"HPS6","HPS6, biogenesis of lysosomal organelles complex 2 subunit 3",TRUE
+"222881_at",0.500388308784901,0.0318058840971576,2.29144639637762,-3.66220080674363,2.14545864540334,"HPSE","heparanase",TRUE
+"219403_s_at",0.577403980266925,0.0615017447072525,1.96968671235025,-4.20839438732166,1.67392780757712,"HPSE","heparanase",TRUE
+"220927_s_at",0.948989397056643,0.770000884480509,-0.29598102214618,-5.89710427612252,-0.124783139794787,"HPSE2","heparanase 2 (inactive)",TRUE
+"39763_at",0.142607803108174,0.000955888740630074,-3.80666280063204,-0.616792509367812,-1.4870090654742,"HPX","hemopexin",TRUE
+"210013_at",0.7768734672127,0.295102878321661,-1.07235347645711,-5.39459187659858,-1.06318667412607,"HPX","hemopexin",TRUE
+"1566916_at",0.670164229230396,0.135998236057342,-1.54712619435675,-4.83659887202208,-0.727383371135413,"HPYR1","Helicobacter pylori responsive 1 (non-protein coding)",TRUE
+"1566917_at",0.831362499339425,0.405531556605075,0.847953100762814,-5.59541295520902,0.231336635507822,"HPYR1","Helicobacter pylori responsive 1 (non-protein coding)",TRUE
+"210086_at",0.633939432589305,0.104815957395653,-1.69121341604327,-4.63503916277866,-1.82553535692745,"HR","hair growth associated",TRUE
+"220163_s_at",0.656723416459198,0.124894560298907,-1.59492785400846,-4.77127223904268,-0.80305355722602,"HR","hair growth associated",TRUE
+"241355_at",0.878788356961452,0.532045014171397,-0.63482314852974,-5.7452802886581,-0.330585858624783,"HR","hair growth associated",TRUE
+"212983_at",0.86481525165637,0.492648117569077,-0.697657696512139,-5.70535758993602,-0.339773172909123,"HRAS","HRas proto-oncogene, GTPase",TRUE
+"219983_at",0.68693205074532,0.15541562812473,-1.47076138548812,-4.93767608862356,-1.4728676878645,"HRASLS","HRAS like suppressor",TRUE
+"219984_s_at",0.78607228223635,0.311495968302382,-1.0357401836157,-5.43026836782297,-1.02702642869379,"HRASLS","HRAS like suppressor",TRUE
+"221122_at",0.871592576046691,0.513008151618812,0.664849183119893,-5.72665293022875,0.492716056900248,"HRASLS2","HRAS like suppressor 2",TRUE
+"216759_at",0.897949253801113,0.586574094744754,0.551850873818203,-5.79243229013844,0.220922769678033,"HRASLS2","HRAS like suppressor 2",TRUE
+"216760_at",0.986421906591669,0.936415903542857,0.0806861966616938,-5.9365130693971,0.0386669112171703,"HRASLS2","HRAS like suppressor 2",TRUE
+"231050_at",0.39032405226982,0.0130072322493939,2.70076540126863,-2.90080045544134,0.971417195331786,"HRASLS5","HRAS like suppressor family member 5",TRUE
+"231452_at",0.7083523771159,0.180329253640362,1.38338152130823,-5.04822322279606,1.01632462913724,"HRASLS5","HRAS like suppressor family member 5",TRUE
+"1560164_at",0.986889306520757,0.938784276568912,-0.0776743598432263,-5.93674530694955,-0.0518439574453264,"HRAT13","heart tissue-associated transcript 13",TRUE
+"207066_at",0.945664467195782,0.754784005357514,-0.316235061641814,-5.89109195765328,-0.169114111864013,"HRC","histidine rich calcium binding protein",TRUE
+"235496_at",0.917102138198416,0.649384170685953,0.460869300304477,-5.83675719616117,0.449819669877583,"HRCT1","histidine rich carboxyl terminus 1",TRUE
+"234293_x_at",0.769591955215474,0.277039028121645,1.11442707369464,-5.35222951815831,0.681210758889056,"HRES1","HTLV-1 related endogenous sequence",TRUE
+"206226_at",0.796174477255647,0.328416397683263,0.99934680919243,-5.46462201837299,0.588878516191144,"HRG","histidine rich glycoprotein",TRUE
+"31835_at",0.859947009633611,0.478245200457743,-0.721337473330747,-5.68937987318136,-0.217620950921341,"HRG","histidine rich glycoprotein",TRUE
+"205580_s_at",0.482017726238942,0.0274004933092561,2.36153830200654,-3.53662644280567,1.90643631337605,"HRH1","histamine receptor H1",TRUE
+"205579_at",0.565795244949651,0.0566992223090071,2.01054771822487,-4.141999862074,2.15278742246036,"HRH1","histamine receptor H1",TRUE
+"220805_at",0.874834820370747,0.521643658771187,0.651154211883262,-5.73525140794129,0.242442656461331,"HRH2","histamine receptor H2",TRUE
+"1555215_a_at",0.854184492233394,0.464711994163653,0.743969952149908,-5.67363521036764,0.224591017555603,"HRH3","histamine receptor H3",TRUE
+"1555715_a_at",0.889174545303693,0.556695635304814,-0.596792248834491,-5.76768373447189,-0.152361697327471,"HRH3","histamine receptor H3",TRUE
+"221663_x_at",0.912244494826693,0.632169194440532,-0.485383650749898,-5.82557965702264,-0.324658763701534,"HRH3","histamine receptor H3",TRUE
+"220447_at",0.961778365989609,0.826690390472834,-0.221553880610659,-5.91580368072852,-0.170126981647246,"HRH3","histamine receptor H3",TRUE
+"221169_s_at",0.827825169467994,0.396970476539254,-0.863766948226676,-5.58267925633467,-0.562862040590677,"HRH4","histamine receptor H4",TRUE
+"221170_at",0.957430653957785,0.807587124360629,-0.246470541092919,-5.9101387396206,-0.197778497651325,"HRH4","histamine receptor H4",TRUE
+"206864_s_at",0.615637099066718,0.0860358189462496,1.79666789036856,-4.47898469387729,1.82770828113173,"HRK","harakiri, BCL2 interacting protein",TRUE
+"237187_at",0.755639383619058,0.249647261955289,1.18222928975696,-5.28093689450018,0.611649420488915,"HRK","harakiri, BCL2 interacting protein",TRUE
+"206863_x_at",0.914910510855952,0.641747297025302,0.471708054772214,-5.83188507037258,0.412680993130453,"HRK","harakiri, BCL2 interacting protein",TRUE
+"206865_at",0.997763494670794,0.988950469801414,0.014006098092283,-5.93958793364474,0.00694448563312378,"HRK","harakiri, BCL2 interacting protein",TRUE
+"219020_at",0.62110896023334,0.0917503233356511,-1.76264804918096,-4.53008898728516,-0.686945427517697,"HS1BP3","HCLS1 binding protein 3",TRUE
+"1568734_a_at",0.869698482173109,0.507275701630626,0.674011141601667,-5.72080481646235,0.33099816719188,"HS1BP3","HCLS1 binding protein 3",TRUE
+"237407_at",0.933609099853387,0.706156007914767,-0.381924295279546,-5.8688861021157,-0.212011109919445,"HS1BP3","HCLS1 binding protein 3",TRUE
+"236530_at",0.971880509429344,0.865429194599074,0.171446075596218,-5.92537699808273,0.10443528695721,"HS1BP3","HCLS1 binding protein 3",TRUE
+"203284_s_at",0.955904644595647,0.800470777880623,-0.255792554189788,-5.90786517455694,-0.0880026498887432,"HS2ST1","heparan sulfate 2-O-sulfotransferase 1",TRUE
+"203283_s_at",0.975398143273847,0.882415360954659,-0.149623400918738,-5.92878539842845,-0.0616679541706553,"HS2ST1","heparan sulfate 2-O-sulfotransferase 1",TRUE
+"203285_s_at",0.978255630670068,0.894952970516998,-0.133564124097453,-5.93099831232463,-0.0474556159521455,"HS2ST1","heparan sulfate 2-O-sulfotransferase 1",TRUE
+"230465_at",0.98416037322447,0.922401722277361,0.098524521259971,-5.93495662506546,0.0450830419148875,"HS2ST1","heparan sulfate 2-O-sulfotransferase 1",TRUE
+"205466_s_at",0.345823377376834,0.00882544593463779,2.87154280401362,-2.56559363174538,3.73662346119368,"HS3ST1","heparan sulfate-glucosamine 3-sulfotransferase 1",TRUE
+"205465_x_at",0.886284607901624,0.549084906065787,0.608437074432267,-5.76096567789434,0.486542694624005,"HS3ST1","heparan sulfate-glucosamine 3-sulfotransferase 1",TRUE
+"213991_s_at",0.94214388523134,0.739634248510978,-0.336534739443548,-5.88467088686494,-0.268000554604513,"HS3ST1","heparan sulfate-glucosamine 3-sulfotransferase 1",TRUE
+"219697_at",0.686108994812404,0.154643198631503,1.47364610832757,-4.93393257591666,0.675479119396812,"HS3ST2","heparan sulfate-glucosamine 3-sulfotransferase 2",TRUE
+"219985_at",0.985710440655746,0.931120020641012,0.0874237298787652,-5.93596158729229,0.113767259724127,"HS3ST3A1","heparan sulfate-glucosamine 3-sulfotransferase 3A1",TRUE
+"227361_at",0.837642003916702,0.422079855776329,-0.81797776523235,-5.6189465226842,-1.53537044744033,"HS3ST3B1","heparan sulfate-glucosamine 3-sulfotransferase 3B1",TRUE
+"1561908_a_at",0.912686134671598,0.633553751695103,0.483401030244636,-5.82650470624266,0.372361527504359,"HS3ST3B1","heparan sulfate-glucosamine 3-sulfotransferase 3B1",TRUE
+"221062_at",0.99494447866405,0.976310310467398,0.0300321278890624,-5.93924419407853,0.0107922736936565,"HS3ST3B1","heparan sulfate-glucosamine 3-sulfotransferase 3B1",TRUE
+"228206_at",0.700240798541278,0.172002449463363,-1.41144524238567,-5.01332470196954,-0.626475023223104,"HS3ST4","heparan sulfate-glucosamine 3-sulfotransferase 4",TRUE
+"240479_at",0.961899417580562,0.826930987042718,0.221241013498297,-5.91587099742406,0.110446038943364,"HS3ST5","heparan sulfate-glucosamine 3-sulfotransferase 5",TRUE
+"239547_at",0.93423034725099,0.708888178411744,0.378190579177884,-5.87025885180905,0.338734099161302,"HS3ST6","heparan sulfate-glucosamine 3-sulfotransferase 6",TRUE
+"225263_at",0.710672261019989,0.183656642089467,-1.37245491482706,-5.06165383575877,-0.716833121514304,"HS6ST1","heparan sulfate 6-O-sulfotransferase 1",TRUE
+"206997_s_at",0.910888708415045,0.62831363691547,-0.490915071632893,-5.82297924868642,-0.261238130894205,"HS6ST1","heparan sulfate 6-O-sulfotransferase 1",TRUE
+"214165_s_at",0.990797621966014,0.953315958281979,-0.0592095950622898,-5.9379760906939,-0.0168420020016797,"HS6ST1","heparan sulfate 6-O-sulfotransferase 1",TRUE
+"1552766_at",0.567292616148537,0.0574059459307507,2.00434640985726,-4.15213515316617,2.88333575378705,"HS6ST2","heparan sulfate 6-O-sulfotransferase 2",TRUE
+"1552767_a_at",0.600661488617326,0.0766495693842357,1.85703975194183,-4.38656088498264,2.81235848725904,"HS6ST2","heparan sulfate 6-O-sulfotransferase 2",TRUE
+"230030_at",0.606900628956089,0.0805383535899923,1.83128919657688,-4.42625061024688,3.72810213075968,"HS6ST2","heparan sulfate 6-O-sulfotransferase 2",TRUE
+"232275_s_at",0.610033432202476,0.0824651346730712,-1.81892831901523,-4.44516157726247,-2.32084121500185,"HS6ST3","heparan sulfate 6-O-sulfotransferase 3",TRUE
+"229714_at",0.819018525257656,0.373865747816767,-0.907580385033029,-5.54625973178092,-0.877628805126775,"HS6ST3","heparan sulfate 6-O-sulfotransferase 3",TRUE
+"1552842_at",0.878647293269438,0.531678114736865,0.635396241228772,-5.74493249886344,0.413355053263178,"HS6ST3","heparan sulfate 6-O-sulfotransferase 3",TRUE
+"232276_at",0.943988850936011,0.74942467439673,-0.32340028111281,-5.8888706407752,-0.231719835940392,"HS6ST3","heparan sulfate 6-O-sulfotransferase 3",TRUE
+"200941_at",0.294892467696083,0.00522692348257385,-3.09746765732726,-2.10968481376872,-1.01014720611604,"HSBP1","heat shock factor binding protein 1",TRUE
+"200942_s_at",0.597654932724127,0.074926234873915,-1.86881660812338,-4.36827789369726,-0.691127390490568,"HSBP1","heat shock factor binding protein 1",TRUE
+"232594_at",0.782257848574678,0.304356004695641,-1.05151456506719,-5.41503403290961,-0.369366191110386,"HSBP1L1","heat shock factor binding protein 1 like 1",TRUE
+"223647_x_at",0.630603891142543,0.101815579419019,-1.70691642431998,-4.61224678391289,-0.636233178479754,"HSCB","HscB mitochondrial iron-sulfur cluster cochaperone",TRUE
+"205404_at",0.977874971442423,0.893239238762453,0.135757005322874,-5.93071090930141,0.0541614279030824,"HSD11B1","hydroxysteroid 11-beta dehydrogenase 1",TRUE
+"1569905_at",0.837609393049242,0.422019359002779,0.818085985978958,-5.61886298479846,0.395211275552073,"HSD11B1L","hydroxysteroid 11-beta dehydrogenase 1 like",TRUE
+"228757_at",0.927217810817605,0.681752245469851,-0.41552780018661,-5.85593365336571,-0.229717390900054,"HSD11B1L","hydroxysteroid 11-beta dehydrogenase 1 like",TRUE
+"204130_at",0.93789466363241,0.725359588926503,-0.355794556786553,-5.87821365747244,-0.377864503338227,"HSD11B2","hydroxysteroid 11-beta dehydrogenase 2",TRUE
+"205829_at",0.425744368467229,0.0180833913663993,-2.55279626478382,-3.18349446581521,-3.67765122750557,"HSD17B1","hydroxysteroid 17-beta dehydrogenase 1",TRUE
+"228595_at",0.940044918888428,0.730731495364472,-0.348530904262703,-5.8806906472114,-0.262357033936587,"HSD17B1","hydroxysteroid 17-beta dehydrogenase 1",TRUE
+"202282_at",0.551933025317273,0.0493837468651505,-2.0791390850916,-4.02852055552139,-0.756664126003884,"HSD17B10","hydroxysteroid 17-beta dehydrogenase 10",TRUE
+"217989_at",0.724853010944214,0.202415810542079,1.31361613112872,-5.13244292054107,1.85536343025266,"HSD17B11","hydroxysteroid 17-beta dehydrogenase 11",TRUE
+"1559518_at",0.72993713735092,0.212278068816202,1.28437522574475,-5.16664820608799,1.11979488402757,"HSD17B12","hydroxysteroid 17-beta dehydrogenase 12",TRUE
+"1554121_at",0.878281464330375,0.531227619756702,0.636100202323376,-5.74450487658123,0.460276910461378,"HSD17B12","hydroxysteroid 17-beta dehydrogenase 12",TRUE
+"1554122_a_at",0.936992192746977,0.719084282246227,0.364304553955177,-5.87524745770303,0.212299154548051,"HSD17B12","hydroxysteroid 17-beta dehydrogenase 12",TRUE
+"217869_at",0.940567117317801,0.733865804746224,0.344301668816018,-5.88210960572465,0.153987655103114,"HSD17B12","hydroxysteroid 17-beta dehydrogenase 12",TRUE
+"219113_x_at",0.699682883631135,0.171110376534648,1.41451566177329,-5.00947143765063,0.918636968831245,"HSD17B14","hydroxysteroid 17-beta dehydrogenase 14",TRUE
+"228713_s_at",0.942684843065067,0.743441087818543,0.331420583425476,-5.88632580750302,0.116661877017918,"HSD17B14","hydroxysteroid 17-beta dehydrogenase 14",TRUE
+"224497_x_at",0.955735662836499,0.797872640868574,-0.259201703387753,-5.90701276637962,-0.219317999141976,"HSD17B14","hydroxysteroid 17-beta dehydrogenase 14",TRUE
+"224494_x_at",0.959290940418208,0.81550024615786,0.23613090680946,-5.91256234093107,0.203260494334944,"HSD17B14","hydroxysteroid 17-beta dehydrogenase 14",TRUE
+"204818_at",0.369623435296638,0.0110783440345971,2.77184874106371,-2.76236597367819,3.73563082007086,"HSD17B2","hydroxysteroid 17-beta dehydrogenase 2",TRUE
+"206985_at",0.821468803512885,0.383787460578642,0.888555046886101,-5.56227943754965,0.413408805243585,"HSD17B3","hydroxysteroid 17-beta dehydrogenase 3",TRUE
+"1563696_at",0.557589172116298,0.0525253445421428,2.04864083189444,-4.07928627523408,1.77382463797251,"HSD17B4","hydroxysteroid 17-beta dehydrogenase 4",TRUE
+"201413_at",0.648323565874229,0.119477298659752,-1.61954535209787,-4.73702565320715,-1.75702522298029,"HSD17B4","hydroxysteroid 17-beta dehydrogenase 4",TRUE
+"37512_at",0.888312537451395,0.554220840782941,-0.600569616410037,-5.76551825690761,-0.313493788933895,"HSD17B6","hydroxysteroid 17-beta dehydrogenase 6",TRUE
+"205700_at",0.92500827123985,0.675311022493092,-0.424477399536498,-5.85230294297841,-0.36767887974295,"HSD17B6","hydroxysteroid 17-beta dehydrogenase 6",TRUE
+"220081_x_at",0.986455005400648,0.937153332349872,0.0797483350080125,-5.93658633281951,0.022882292342338,"HSD17B7","hydroxysteroid 17-beta dehydrogenase 7",TRUE
+"224058_s_at",0.990969428303934,0.957511182951414,-0.0538831202256102,-5.93826944515105,-0.0320725329980709,"HSD17B7P2","hydroxysteroid 17-beta dehydrogenase 7 pseudogene 2",TRUE
+"213540_at",0.78515014907967,0.31044907146711,1.03803700562184,-5.42806307178203,0.818172449036691,"HSD17B8","hydroxysteroid 17-beta dehydrogenase 8",TRUE
+"204515_at",0.9286288141895,0.68625414634511,0.409293216670482,-5.85841795737633,0.534166172365737,"HSD3B1","hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1",TRUE
+"241111_at",0.996261754016157,0.981897118853033,0.0229480637023493,-5.93942698992215,0.0189605091882568,"HSD3B1","hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1",TRUE
+"206294_at",0.833430578034454,0.410954382609556,0.838046327654882,-5.60327831206564,0.611585561375065,"HSD3B2","hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2",TRUE
+"222817_at",0.899094059893116,0.589318624334899,-0.547781115811648,-5.79458068194137,-0.521991084631198,"HSD3B7","hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7",TRUE
+"223248_at",0.236926796662401,0.00308102336400488,-3.32119742429567,-1.64693263464109,-1.34297344718475,"HSDL1","hydroxysteroid dehydrogenase like 1",TRUE
+"215436_at",0.794812714107118,0.326981662156587,1.00238126708405,-5.46180015774771,0.461988198141803,"HSDL2","hydroxysteroid dehydrogenase like 2",TRUE
+"209512_at",0.901788521024914,0.599688591046869,-0.532487240862283,-5.80251598956235,-0.241535521685494,"HSDL2","hydroxysteroid dehydrogenase like 2",TRUE
+"1559128_at",0.918482003504129,0.653881911374389,0.454512020241991,-5.83956322956638,0.284749923866483,"HSDL2","hydroxysteroid dehydrogenase like 2",TRUE
+"209513_s_at",0.979588787486838,0.902454478968997,-0.123972977948422,-5.93220043314701,-0.0594614122888792,"HSDL2","hydroxysteroid dehydrogenase like 2",TRUE
+"213756_s_at",0.48580305784244,0.0284685152005014,2.343642072484,-3.56889462008603,0.878377565511741,"HSF1","heat shock transcription factor 1",TRUE
+"202344_at",0.617775129514679,0.0887732164366717,1.78013631777551,-4.50390741329262,0.75754355456254,"HSF1","heat shock transcription factor 1",TRUE
+"211220_s_at",0.95018792835023,0.773659578306891,-0.291130324023884,-5.89848564376686,-0.116123100560721,"HSF2","heat shock transcription factor 2",TRUE
+"209657_s_at",0.997056683282451,0.984939626762953,-0.0190906983475844,-5.9395059698302,-0.00599989250661181,"HSF2","heat shock transcription factor 2",TRUE
+"207020_at",0.0952827619788257,0.000409510755036583,4.15361115761071,0.130953874932223,1.35498897409674,"HSF2BP","heat shock transcription factor 2 binding protein",TRUE
+"210977_s_at",0.710672261019989,0.183832576326412,-1.37188155447962,-5.06235614621828,-0.712188980310185,"HSF4","heat shock transcription factor 4",TRUE
+"230718_at",0.909689149064145,0.624411962967138,0.496528508743722,-5.82031085502827,0.361912798009675,"HSF5","heat shock transcription factor 5",TRUE
+"220314_at",0.97577669713908,0.884186646664133,-0.14735223625393,-5.92911356425562,-0.10777188175606,"HSFX1///HSFX2","heat shock transcription factor family, X-linked 1///heat shock transcription factor family, X-linked 2",TRUE
+"224052_at",0.722192678020526,0.198458812829738,1.3256602908215,-5.11816469684052,0.973368169223829,"HSFY2///HSFY1","heat shock transcription factor, Y-linked 2///heat shock transcription factor, Y-linked 1",TRUE
+"224007_at",0.901788521024914,0.59963652478599,0.532563706289361,-5.80247685864315,0.240454458779302,"HSFY2///HSFY1","heat shock transcription factor, Y-linked 2///heat shock transcription factor, Y-linked 1",TRUE
+"1552623_at",0.805670827550507,0.34508724152918,0.964740434112698,-5.4962528470432,1.17594183095056,"HSH2D","hematopoietic SH2 domain containing",TRUE
+"210211_s_at",0.943988850936011,0.749733454739722,0.322986988084119,-5.88900010639775,0.0674966272615798,"HSP90AA1","heat shock protein 90 alpha family class A member 1",TRUE
+"211968_s_at",0.958325326717984,0.811506966542333,0.241345340988469,-5.91135298971842,0.0702304466507897,"HSP90AA1","heat shock protein 90 alpha family class A member 1",TRUE
+"214328_s_at",0.972034160883838,0.865914875903213,-0.17082097190943,-5.92548105950001,-0.0359240612570471,"HSP90AA1","heat shock protein 90 alpha family class A member 1",TRUE
+"211969_at",0.978438521100347,0.896315898817229,-0.131820608176379,-5.93122348654261,-0.0290347274386775,"HSP90AA1","heat shock protein 90 alpha family class A member 1",TRUE
+"200064_at",0.812302873476553,0.360631320121967,0.933485736144434,-5.52394384238587,0.225908518422758,"HSP90AB1","heat shock protein 90 alpha family class B member 1",TRUE
+"1557910_at",0.833850553362692,0.411534034420464,0.836992310362526,-5.60411005480027,0.244751054792046,"HSP90AB1","heat shock protein 90 alpha family class B member 1",TRUE
+"214359_s_at",0.925091998149497,0.675738516319758,0.42388234355033,-5.85254670782025,0.110781592442438,"HSP90AB1","heat shock protein 90 alpha family class B member 1",TRUE
+"216449_x_at",0.623667408398064,0.0951462680587046,1.74328451302307,-4.55885596530246,0.901672618622326,"HSP90B1","heat shock protein 90 beta family member 1",TRUE
+"216450_x_at",0.679041081350052,0.146609301586696,1.50436645345203,-4.89370047432697,0.624983332443788,"HSP90B1","heat shock protein 90 beta family member 1",TRUE
+"214434_at",0.707898177720919,0.179620754646146,-1.38572874262985,-5.04532656810836,-0.957253543773218,"HSPA12A","heat shock protein family A (Hsp70) member 12A",TRUE
+"220763_at",0.73936001229895,0.22704749411697,-1.24248501478887,-5.21450441154312,-0.456050911074798,"HSPA12A","heat shock protein family A (Hsp70) member 12A",TRUE
+"229172_at",0.615821255316333,0.0864680758580204,1.79402753832119,-4.48297649185518,1.33928449745481,"HSPA12B","heat shock protein family A (Hsp70) member 12B",TRUE
+"234610_at",0.950482170269574,0.774710332618076,0.289738555834048,-5.89887780774896,0.235883021027551,"HSPA12B","heat shock protein family A (Hsp70) member 12B",TRUE
+"202558_s_at",0.726696341943087,0.206486396089265,1.3014160622566,-5.14679363133799,0.645065785486432,"HSPA13","heat shock protein family A (Hsp70) member 13",TRUE
+"202557_at",0.897699110987203,0.584966321496422,0.554239359341759,-5.79116423784578,0.253769454561612,"HSPA13","heat shock protein family A (Hsp70) member 13",TRUE
+"219212_at",0.762481923780801,0.261957027013345,-1.15111304429211,-5.31411455836669,-0.323898480629804,"HSPA14","heat shock protein family A (Hsp70) member 14",TRUE
+"227650_at",0.942502815705589,0.742132822068876,0.333177100725103,-5.88576023216607,0.107769620344008,"HSPA14","heat shock protein family A (Hsp70) member 14",TRUE
+"226887_at",0.993213867476782,0.967491458204484,0.0412177710333931,-5.93885604080961,0.0116529423270446,"HSPA14","heat shock protein family A (Hsp70) member 14",TRUE
+"202581_at",0.640067422642767,0.110619868385515,1.66188919053666,-4.67717561990808,1.59969065366939,"HSPA1B///HSPA1A","heat shock protein family A (Hsp70) member 1B///heat shock protein family A (Hsp70) member 1A",TRUE
+"200799_at",0.865345395265289,0.494734894600493,0.694260078890584,-5.70760839116646,0.648259553683456,"HSPA1B///HSPA1A","heat shock protein family A (Hsp70) member 1B///heat shock protein family A (Hsp70) member 1A",TRUE
+"233694_at",0.750020866111355,0.242942286947089,1.19966185397006,-5.26201193589519,0.50126417417808,"HSPA1L","heat shock protein family A (Hsp70) member 1 like",TRUE
+"210189_at",0.837368340567858,0.421201097646749,0.819550703741275,-5.61773131943063,0.703676786672206,"HSPA1L","heat shock protein family A (Hsp70) member 1 like",TRUE
+"200800_s_at",0.812302873476553,0.359239194762101,0.936247405148183,-5.52153075714359,1.27542966761337,"HSPA1L///HSPA1B///HSPA1A","heat shock protein family A (Hsp70) member 1 like///heat shock protein family A (Hsp70) member 1B///heat shock protein family A (Hsp70) member 1A",TRUE
+"211538_s_at",0.748067267263424,0.240024582891673,1.20736061842485,-5.25357741858047,1.11155440030763,"HSPA2","heat shock protein family A (Hsp70) member 2",TRUE
+"208814_at",0.678455276397227,0.145964564885332,-1.5068908750538,-4.89036481318042,-1.11103987766912,"HSPA4","heat shock protein family A (Hsp70) member 4",TRUE
+"208815_x_at",0.862634144901168,0.485912684637198,-0.708680825961724,-5.69798302479369,-0.240891403759301,"HSPA4","heat shock protein family A (Hsp70) member 4",TRUE
+"211015_s_at",0.895657764833717,0.575219510825261,-0.568789779561383,-5.78332462742266,-0.195713280735777,"HSPA4","heat shock protein family A (Hsp70) member 4",TRUE
+"211016_x_at",0.934048461921637,0.70783958708808,-0.379622907721625,-5.86973380981596,-0.138999980114564,"HSPA4","heat shock protein family A (Hsp70) member 4",TRUE
+"205543_at",0.673622120503302,0.139988069019851,1.53073692316078,-4.85863558212667,0.877440829481367,"HSPA4L","heat shock protein family A (Hsp70) member 4 like",TRUE
+"1556194_a_at",0.729083413548563,0.210771499959742,1.28877304438945,-5.16154552483171,0.82700442059198,"HSPA4L","heat shock protein family A (Hsp70) member 4 like",TRUE
+"230031_at",0.538307479093131,0.0438468712018561,2.13740116114675,-3.9302018704646,0.643760413380324,"HSPA5","heat shock protein family A (Hsp70) member 5",TRUE
+"211936_at",0.713330901550199,0.188072616639484,1.35819293414199,-5.07905074935681,0.381658571798242,"HSPA5","heat shock protein family A (Hsp70) member 5",TRUE
+"117_at",0.714795139167042,0.190417972238442,-1.35072544091279,-5.0880991490467,-0.468606657374693,"HSPA6","heat shock protein family A (Hsp70) member 6",TRUE
+"213418_at",0.730101539866086,0.212825172047411,-1.28278414452114,-5.16849064100105,-0.94611345227229,"HSPA6","heat shock protein family A (Hsp70) member 6",TRUE
+"200692_s_at",0.689866328122798,0.159032010967714,-1.45740818420141,-4.95492714096764,-0.491653502046105,"HSPA9","heat shock protein family A (Hsp70) member 9",TRUE
+"200691_s_at",0.71557775024401,0.191344247070278,-1.34779616642269,-5.09163716923069,-0.471635065622095,"HSPA9","heat shock protein family A (Hsp70) member 9",TRUE
+"200690_at",0.73223722457785,0.216296696242062,-1.27276111366674,-5.18005230487057,-0.428519976305203,"HSPA9","heat shock protein family A (Hsp70) member 9",TRUE
+"232200_at",0.966051687342135,0.841463289399571,0.202384086523492,-5.91975337498182,0.0580286009967885,"HSPA9","heat shock protein family A (Hsp70) member 9",TRUE
+"201841_s_at",0.839827539028818,0.428646132677425,-0.806288709032056,-5.62790851484388,-0.506543452985321,"HSPB1","heat shock protein family B (small) member 1",TRUE
+"214163_at",0.96287357728432,0.831587032504866,0.215190787234069,-5.91715414705355,0.110467130460383,"HSPB11","heat shock protein family B (small) member 11",TRUE
+"203960_s_at",0.977266666118723,0.891345845560283,-0.138180573671765,-5.9303878371219,-0.0672232250035432,"HSPB11","heat shock protein family B (small) member 11",TRUE
+"215691_x_at",0.979998976135556,0.904666932780526,-0.121146532068547,-5.93253763460336,-0.0506603298438666,"HSPB11","heat shock protein family B (small) member 11",TRUE
+"205824_at",0.901781358899845,0.598710670411114,-0.533923969617349,-5.80177983496012,-0.317688367289655,"HSPB2","heat shock protein family B (small) member 2",TRUE
+"238805_at",0.916349280948806,0.646732770195465,-0.464625928698023,-5.83508111348521,-0.396756312540009,"HSPB2-C11orf52///C11orf52///HSPB2","HSPB2-C11orf52 readthrough (NMD candidate)///chromosome 11 open reading frame 52///heat shock protein family B (small) member 2",TRUE
+"206375_s_at",0.982686986709969,0.915898420772809,0.106813200738294,-5.93412807571132,0.0765896463062861,"HSPB3","heat shock protein family B (small) member 3",TRUE
+"226304_at",0.776696310319783,0.294092559312976,-1.07465693339479,-5.39231023735385,-0.735599349098984,"HSPB6","heat shock protein family B (small) member 6",TRUE
+"214767_s_at",0.847644062908097,0.446602412181026,0.7748789836175,-5.65138913313035,0.375769182282438,"HSPB6","heat shock protein family B (small) member 6",TRUE
+"218934_s_at",0.783844746433788,0.306757945553559,1.04617898956759,-5.42021011983371,0.646581352829206,"HSPB7","heat shock protein family B (small) member 7",TRUE
+"235682_s_at",0.954577684533304,0.79286594159374,0.265780152818064,-5.90533623115555,0.0973095386263729,"HSPB7","heat shock protein family B (small) member 7",TRUE
+"221667_s_at",0.7717895132349,0.28165229651238,-1.10349768545637,-5.36337330424178,-1.66126514994106,"HSPB8","heat shock protein family B (small) member 8",TRUE
+"233057_at",0.906507435035949,0.614433748370628,-0.510958849140471,-5.81331538402638,-0.447683771847302,"HSPB8","heat shock protein family B (small) member 8",TRUE
+"230510_at",0.973420642050654,0.871280464209874,0.163919683779656,-5.926604726421,0.129651115740685,"HSPB9","heat shock protein family B (small) member 9",TRUE
+"219284_at",0.975398143273847,0.881219157320192,0.151157643386442,-5.92856087767346,0.0680302665765504,"HSPBAP1","HSPB1 associated protein 1",TRUE
+"202415_s_at",0.954356644670828,0.789894855807754,0.269689603741223,-5.90432012828993,0.102207876031265,"HSPBP1","HSPA (Hsp70) binding protein 1",TRUE
+"1560636_a_at",0.64918766814117,0.119899352041875,1.61759428052852,-4.7397547004033,0.961441316188655,"HSPC081","uncharacterized LOC100286989",TRUE
+"233217_at",0.941397317345279,0.737816553892587,0.338979877024531,-5.88387079280425,0.157642226024408,"HSPC102","uncharacterized HSPC102",TRUE
+"232227_at",0.680972290639028,0.148867195111211,1.49559673386273,-4.90525355653733,1.1304644352796,"HSPC324","uncharacterized LOC101928612",TRUE
+"243845_at",0.704130394289074,0.175925813193773,1.3980905820034,-5.03000403063558,0.691467412622451,"HSPD1","heat shock protein family D (Hsp60) member 1",TRUE
+"241716_at",0.796963640275795,0.329959446716254,0.996093506279316,-5.46763876468837,0.937302665276441,"HSPD1","heat shock protein family D (Hsp60) member 1",TRUE
+"243372_at",0.806804183253503,0.348073106073775,-0.958663795722585,-5.50170199951055,-0.282842049985488,"HSPD1","heat shock protein family D (Hsp60) member 1",TRUE
+"200806_s_at",0.954618087644887,0.793152731813018,0.265403009811458,-5.90543347480684,0.0676351748062114,"HSPD1","heat shock protein family D (Hsp60) member 1",TRUE
+"200807_s_at",0.970957388308028,0.861143718352857,0.176964825967096,-5.92444184493962,0.0361956230874938,"HSPD1","heat shock protein family D (Hsp60) member 1",TRUE
+"205133_s_at",0.805746717966166,0.345888522972877,0.963106215681483,-5.49772140672897,0.284458037216593,"HSPE1","heat shock protein family E (Hsp10) member 1",TRUE
+"202918_s_at",0.780626177489045,0.302199061229687,-1.05633143688896,-5.41034083581369,-0.285765232899806,"HSPE1-MOB4///MOB4","HSPE1-MOB4 readthrough///MOB family member 4, phocein",TRUE
+"201654_s_at",0.51470556386048,0.0351041485789665,2.2445769741388,-3.74493408406986,2.35105210516514,"HSPG2","heparan sulfate proteoglycan 2",TRUE
+"201655_s_at",0.540483367247649,0.0447670425880984,2.12727576680154,-3.94741286770863,2.66777047296465,"HSPG2","heparan sulfate proteoglycan 2",TRUE
+"208744_x_at",0.686998148149102,0.155519404422501,1.47037470841565,-4.93817742959689,0.678905819925385,"HSPH1","heat shock protein family H (Hsp110) member 1",TRUE
+"206976_s_at",0.691970774776447,0.16144086333879,1.44864937353636,-4.96617327371732,0.552092116034487,"HSPH1","heat shock protein family H (Hsp110) member 1",TRUE
+"235573_at",0.883470040615382,0.541603087724671,0.619967922414296,-5.75418999267565,0.304872386972084,"HSPH1","heat shock protein family H (Hsp110) member 1",TRUE
+"207180_s_at",0.611470335211357,0.0835340793942197,1.81217824949073,-4.45544961069143,1.13150231711286,"HTATIP2","HIV-1 Tat interactive protein 2",TRUE
+"209448_at",0.687949239097856,0.157311226274271,1.46373103054173,-4.94677452814092,0.917555510234781,"HTATIP2","HIV-1 Tat interactive protein 2",TRUE
+"210253_at",0.875520432940449,0.522938229850188,0.649111977185854,-5.73651892524781,0.407750647270268,"HTATIP2","HIV-1 Tat interactive protein 2",TRUE
+"229102_at",0.973493137611142,0.872264223346776,0.162655253924747,-5.92680559177536,0.128532239353834,"HTATIP2","HIV-1 Tat interactive protein 2",TRUE
+"202601_s_at",0.933314818367461,0.705034634260867,0.383458335063827,-5.86831823813714,0.101938066362392,"HTATSF1","HIV-1 Tat specific factor 1",TRUE
+"202602_s_at",0.96496567842849,0.837409233654053,-0.207636732530659,-5.91870651124639,-0.07454743219993,"HTATSF1","HIV-1 Tat specific factor 1",TRUE
+"1558882_at",0.86481525165637,0.492432992864752,-0.698008423156148,-5.70512464898832,-0.799508021422604,"HTATSF1P2","HIV-1 Tat specific factor 1 pseudogene 2",TRUE
+"206639_x_at",0.969882914559333,0.857242656154923,-0.181993426619312,-5.92356403119417,-0.116548474850632,"HTN1","histatin 1",TRUE
+"206786_at",0.823274744098629,0.390068286727574,-0.876677315269821,-5.57212128774747,-0.519436881777448,"HTN3","histatin 3",TRUE
+"221351_at",0.962730045874007,0.830140064247463,-0.217070137305623,-5.91675936076896,-0.129876789370596,"HTR1A","5-hydroxytryptamine receptor 1A",TRUE
+"210799_at",0.906476756086155,0.613726115062712,0.511986367317419,-5.81280981407576,0.328064269866849,"HTR1B","5-hydroxytryptamine receptor 1B",TRUE
+"207368_at",0.255533790235106,0.00364682988889777,3.2502244336824,-1.79477532691417,3.24116340327567,"HTR1D","5-hydroxytryptamine receptor 1D",TRUE
+"207404_s_at",0.642613985059507,0.113137672065529,1.64957072509903,-4.69470892138911,0.798718509202814,"HTR1E","5-hydroxytryptamine receptor 1E",TRUE
+"221458_at",0.871744769522775,0.513824380714117,0.663549291074264,-5.72747644541488,0.351482253898275,"HTR1F","5-hydroxytryptamine receptor 1F",TRUE
+"211616_s_at",0.593337376134677,0.0700380953807653,1.90355749569634,-4.31387107112808,1.04559578439053,"HTR2A","5-hydroxytryptamine receptor 2A",TRUE
+"207135_at",0.868397087637799,0.504031692417464,-0.679221659326838,-5.71744475490518,-0.305655422771872,"HTR2A","5-hydroxytryptamine receptor 2A",TRUE
+"244130_at",0.976433695486417,0.888224053481402,0.142178367475726,-5.92984244505865,0.0974232212290946,"HTR2A","5-hydroxytryptamine receptor 2A",TRUE
+"206638_at",0.971216837324271,0.862685246927501,0.174979037676433,-5.92478173917733,0.176641628930233,"HTR2B","5-hydroxytryptamine receptor 2B",TRUE
+"211479_s_at",0.697172073261335,0.166859613379298,1.42932493331503,-4.99078984064163,0.89792060578236,"HTR2C","5-hydroxytryptamine receptor 2C",TRUE
+"207307_at",0.950240579085849,0.774216531137869,0.290392543672911,-5.89869376319,0.336030353289808,"HTR2C","5-hydroxytryptamine receptor 2C",TRUE
+"216615_s_at",0.722192678020526,0.198463350298268,1.32564637293368,-5.11818125974866,0.433587391541684,"HTR3A","5-hydroxytryptamine receptor 3A",TRUE
+"217002_s_at",0.822873158500962,0.388715640679998,0.879224729314073,-5.57002085734345,0.448927917273758,"HTR3A","5-hydroxytryptamine receptor 3A",TRUE
+"221084_at",0.962966981693287,0.832017562234858,0.214631760272988,-5.91727091975751,0.116537784801261,"HTR3B","5-hydroxytryptamine receptor 3B",TRUE
+"1553041_at",0.949240828072432,0.770885985332823,-0.294806894508201,-5.897440717195,-0.0918884635718991,"HTR3C","5-hydroxytryptamine receptor 3C",TRUE
+"207577_at",0.55937703282623,0.0529807349307169,2.04435607168829,-4.08637912855089,1.32950253122267,"HTR4","5-hydroxytryptamine receptor 4",TRUE
+"216939_s_at",0.810589895425672,0.354702574267201,-0.945297303918884,-5.51357730308724,-0.576538399773211,"HTR4","5-hydroxytryptamine receptor 4",TRUE
+"207578_s_at",0.867099100798202,0.498947488315866,0.687426118883134,-5.71210387334343,0.405398931498179,"HTR4","5-hydroxytryptamine receptor 4",TRUE
+"221362_at",0.718706241731185,0.194647573335644,1.33743953349124,-5.10409443115911,0.830135859983713,"HTR5A","5-hydroxytryptamine receptor 5A",TRUE
+"206944_at",0.937462538530338,0.722471672142515,-0.359707521646878,-5.87685837382761,-0.11358783220359,"HTR6","5-hydroxytryptamine receptor 6",TRUE
+"1552857_a_at",0.972112264314695,0.866286709724826,-0.170342444494388,-5.92556046412688,-0.118658476028998,"HTR6","5-hydroxytryptamine receptor 6",TRUE
+"236281_x_at",0.0952827619788257,0.000408629310766703,4.15449074716146,0.132854266668343,2.37200459859515,"HTR7","5-hydroxytryptamine receptor 7",TRUE
+"207818_s_at",0.621503477846441,0.0918964293659531,1.76180240500422,-4.53135018655426,1.44500053847434,"HTR7","5-hydroxytryptamine receptor 7",TRUE
+"207927_at",0.770075820151416,0.278768500540794,1.11031435526464,-5.35643434853137,0.351965428780892,"HTR7","5-hydroxytryptamine receptor 7",TRUE
+"236115_at",0.95018792835023,0.773675025619265,0.291109859164195,-5.89849142373345,0.163728626486845,"HTR7P1","5-hydroxytryptamine receptor 7 pseudogene 1",TRUE
+"216099_at",0.963505878933446,0.833611012292048,-0.212563331171436,-5.91770035533608,-0.141889182366537,"HTR7P1","5-hydroxytryptamine receptor 7 pseudogene 1",TRUE
+"216098_s_at",0.794620886196317,0.326687095536057,1.00300541648267,-5.46121877452356,0.55122038464207,"HTR7P1///HTR7","5-hydroxytryptamine receptor 7 pseudogene 1///5-hydroxytryptamine receptor 7",TRUE
+"201185_at",0.0533657154833195,8.32522178924559e-05,4.80413565972407,1.53281145416588,3.62718858143852,"HTRA1","HtrA serine peptidase 1",TRUE
+"203089_s_at",0.765934384067577,0.266322424792112,1.14033842968984,-5.32542178293588,0.353289054354098,"HTRA2","HtrA serine peptidase 2",TRUE
+"211152_s_at",0.76923099885665,0.275178584483534,1.1188721733682,-5.34766937273045,0.363813933225135,"HTRA2","HtrA serine peptidase 2",TRUE
+"228580_at",0.55937703282623,0.0530579292565639,2.04363301293507,-4.08757509434916,0.774309533214931,"HTRA3","HtrA serine peptidase 3",TRUE
+"226944_at",0.863621091805053,0.488994991030973,0.703625515201644,-5.70137875100854,0.450724977495323,"HTRA3","HtrA serine peptidase 3",TRUE
+"1553706_at",0.746535697909741,0.238209456637833,1.21218570478176,-5.24826734822076,0.873011940990814,"HTRA4","HtrA serine peptidase 4",TRUE
+"202389_s_at",0.603702127972549,0.0777140011945614,-1.84988042579421,-4.39763529394393,-0.619473673596966,"HTT","huntingtin",TRUE
+"202390_s_at",0.889554937737352,0.557698475642633,-0.59526407098578,-5.76855605301714,-0.367103715083819,"HTT","huntingtin",TRUE
+"1555935_s_at",0.407748633394319,0.0156117467277195,-2.61916114670971,-3.05765953745304,-2.41652019238298,"HUNK","hormonally up-regulated Neu-associated kinase",TRUE
+"219535_at",0.994050962712312,0.972146787216726,-0.0353124727522144,-5.93907614553184,-0.0123013510612902,"HUNK","hormonally up-regulated Neu-associated kinase",TRUE
+"204884_s_at",0.853297110808539,0.459985191170456,0.751966773549297,-5.66796183573193,0.258083390059658,"HUS1","HUS1 checkpoint clamp component",TRUE
+"204883_s_at",0.871744769522775,0.513509855408804,0.66405005463629,-5.7271593816456,0.174819821771464,"HUS1","HUS1 checkpoint clamp component",TRUE
+"217618_x_at",0.884122836669679,0.542782258404049,-0.618145013382142,-5.7552693195563,-0.201042528478595,"HUS1","HUS1 checkpoint clamp component",TRUE
+"1553661_a_at",0.614024511254138,0.0849677681631835,1.80324130425134,-4.46902822446739,0.901245892874432,"HUS1B","HUS1 checkpoint clamp component B",TRUE
+"1553660_at",0.622434989367596,0.0927759860337014,1.7567358823913,-4.53889710291519,1.12714931339541,"HUS1B","HUS1 checkpoint clamp component B",TRUE
+"214673_s_at",0.734861913384601,0.219800334208293,1.26277006858964,-5.19149996185824,0.972593066620787,"HUWE1","HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase",TRUE
+"208598_s_at",0.812302873476553,0.360528326722512,0.93368980698547,-5.52376575392299,0.274338401968491,"HUWE1","HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase",TRUE
+"208599_at",0.898609426925686,0.588051363090937,0.549659122429737,-5.79359121684105,0.412767455460355,"HUWE1","HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase",TRUE
+"236294_at",0.921729477898827,0.666471281684331,0.436817372558486,-5.84717216064587,0.278685026730858,"HUWE1","HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase",TRUE
+"207783_x_at",0.931582451098271,0.697570491272823,0.393693408668233,-5.86447204617386,0.0922930567744675,"HUWE1","HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase",TRUE
+"226879_at",0.56861088242915,0.0581141279990709,1.9981999648707,-4.16216010704072,1.00356155524772,"HVCN1","hydrogen voltage gated channel 1",TRUE
+"210619_s_at",0.909052380289506,0.62230893243083,0.4995609017069,-5.81885705776604,0.425553225567397,"HYAL1","hyaluronoglucosaminidase 1",TRUE
+"206855_s_at",0.977063818674184,0.890615535905027,-0.139115605425465,-5.93026166794589,-0.100182006409565,"HYAL2","hyaluronoglucosaminidase 2",TRUE
+"211728_s_at",0.974536463688956,0.875249088101492,-0.158820446214741,-5.92740529500732,-0.145517878109892,"HYAL3","hyaluronoglucosaminidase 3",TRUE
+"220249_at",0.328663980090165,0.0078065685317226,2.92489473768033,-2.45911818024673,2.19329545013181,"HYAL4","hyaluronoglucosaminidase 4",TRUE
+"1564777_at",0.731314021977412,0.214373492316042,-1.27829836809198,-5.1736745882812,-0.887413690026687,"HYALP1","hyaluronoglucosaminidase pseudogene 1",TRUE
+"1554908_at",0.830635993561085,0.404072204773091,0.85063355047572,-5.59327002401993,0.356733228830837,"HYDIN","HYDIN, axonemal central pair apparatus protein",TRUE
+"1553468_at",0.998940972058269,0.996538478293677,-0.00438759998316913,-5.93967410428476,-0.00359810740080047,"HYDIN2","HYDIN2, axonemal central pair apparatus protein (pseudogene)",TRUE
+"223769_x_at",0.771153198056133,0.280055197084638,1.10726658709645,-5.35954147985292,0.634833943986262,"HYI","hydroxypyruvate isomerase (putative)",TRUE
+"221435_x_at",0.849935057946582,0.451790540360254,0.765948006988493,-5.65790492533333,0.421508776060779,"HYI","hydroxypyruvate isomerase (putative)",TRUE
+"223622_s_at",0.858826390511142,0.475048487771721,0.726649195898548,-5.68572617141717,0.753607398065215,"HYI","hydroxypyruvate isomerase (putative)",TRUE
+"240447_at",0.944138668824804,0.750182280562523,0.322386350768441,-5.88918796614908,0.241601934890541,"HYI-AS1","HYI antisense RNA 1",TRUE
+"236150_at",0.992816117752561,0.96603232673866,-0.0430689826025797,-5.9387800495848,-0.0275792156662469,"HYKK","hydroxylysine kinase",TRUE
+"227687_at",0.972278576610345,0.866572422525804,0.169974777237229,-5.92562132223223,0.0764209414136374,"HYLS1","HYLS1, centriolar and ciliogenesis associated",TRUE
+"215513_at",0.743000985898779,0.233194273763567,1.22566330991199,-5.23333795571445,1.06059591375176,"HYMAI","hydatidiform mole associated and imprinted (non-protein coding)",TRUE
+"200825_s_at",0.90985106339387,0.624798079428447,0.495972274562428,-5.82057658808183,0.192505054138902,"HYOU1","hypoxia up-regulated 1",TRUE
+"233809_at",0.978928101156583,0.897390644053695,-0.130446043617789,-5.93139892856903,-0.0446922902899418,"HYPK","huntingtin interacting protein K",TRUE
+"215142_at",0.908882763411412,0.621539002734483,0.500672262291867,-5.8183220827666,0.328330888532191,"HYPM","huntingtin interacting protein M",TRUE
+"230621_at",0.682539393883246,0.150473407727122,1.48942399639077,-4.91335288730741,0.643265108972164,"IAH1","isoamyl acetate-hydrolyzing esterase 1 homolog",TRUE
+"225908_at",0.914562242038395,0.640020341211138,-0.474166987732117,-5.83076432806607,-0.158595681995035,"IAH1","isoamyl acetate-hydrolyzing esterase 1 homolog",TRUE
+"237897_at",0.92346045063848,0.671459747067253,-0.429845298860569,-5.85008879510926,-0.28889873299685,"IAH1","isoamyl acetate-hydrolyzing esterase 1 homolog",TRUE
+"207062_at",0.92051722798026,0.66215430802658,-0.442868741209175,-5.84460334293407,-0.37863943494569,"IAPP","islet amyloid polypeptide",TRUE
+"204744_s_at",0.934867348047609,0.710613538660657,0.37583556544626,-5.87111786271364,0.131181634483701,"IARS","isoleucyl-tRNA synthetase",TRUE
+"217900_at",0.733981824228023,0.218156061928571,-1.26744355750222,-5.18615471826655,-0.420648138418905,"IARS2","isoleucyl-tRNA synthetase 2, mitochondrial",TRUE
+"236629_at",0.920835753388243,0.663456476144912,-0.44104165183484,-5.84538260130254,-0.158010486353517,"IBA57","IBA57 homolog, iron-sulfur cluster assembly",TRUE
+"1558896_at",0.97304633500821,0.869052805514577,-0.166783917902478,-5.92614398138923,-0.0659346198581341,"IBA57","IBA57 homolog, iron-sulfur cluster assembly",TRUE
+"231983_at",0.975658039071793,0.884007747555145,-0.147581586697624,-5.92908065224462,-0.0894300107775337,"IBA57","IBA57 homolog, iron-sulfur cluster assembly",TRUE
+"215490_at",0.976422537443518,0.887859131431964,0.142645843442079,-5.92977765668331,0.0738006146175438,"IBA57","IBA57 homolog, iron-sulfur cluster assembly",TRUE
+"238188_at",0.957571530817866,0.80935963102534,0.244152158270366,-5.91069114760385,0.154971699978668,"IBA57-AS1","IBA57 antisense RNA 1 (head to head)",TRUE
+"236028_at",0.812302873476553,0.358083705941428,-0.938545103472566,-5.51951808957984,-0.72159479012646,"IBSP","integrin binding sialoprotein",TRUE
+"207370_at",0.86506123498463,0.49416620635414,0.695185183337631,-5.7069965811376,0.421416436116833,"IBSP","integrin binding sialoprotein",TRUE
+"215086_at",0.868714061424964,0.504831309989125,0.677935567023876,-5.71827640696892,0.470273863926387,"IBTK","inhibitor of Bruton tyrosine kinase",TRUE
+"210970_s_at",0.904381089098038,0.607748667532589,0.520688373361222,-5.80848847430929,0.177046278595794,"IBTK","inhibitor of Bruton tyrosine kinase",TRUE
+"230639_at",0.598618215299661,0.075574420257116,1.86435962222898,-4.37520676872197,0.964462304238852,"ICA1","islet cell autoantigen 1",TRUE
+"214191_at",0.775581183114088,0.292821960688351,-1.07756187523687,-5.38942657197878,-0.834985105702584,"ICA1","islet cell autoantigen 1",TRUE
+"210547_x_at",0.776955214137673,0.295587611104445,-1.07125032376252,-5.3956830300611,-1.11028052313733,"ICA1","islet cell autoantigen 1",TRUE
+"211740_at",0.891653456393983,0.561461034924318,0.589543181532187,-5.77180247054143,0.516879464760476,"ICA1","islet cell autoantigen 1",TRUE
+"207949_s_at",0.907224306064369,0.616298585749296,-0.50825367745627,-5.81464167365097,-0.58131611998298,"ICA1","islet cell autoantigen 1",TRUE
+"204002_s_at",0.928586479058937,0.686056857336085,-0.409566090605122,-5.85830999808305,-0.250679743433403,"ICA1","islet cell autoantigen 1",TRUE
+"1554205_s_at",0.818598668505758,0.37199212028072,0.911210410418526,-5.54316756495798,0.308016235325982,"ICA1L","islet cell autoantigen 1 like",TRUE
+"223881_at",0.897375964261386,0.583750402796078,-0.55604787754654,-5.79020055487714,-0.185622247117213,"ICA1L","islet cell autoantigen 1 like",TRUE
+"1555671_at",0.930065981387326,0.691309038675783,0.402312407130751,-5.86115575117288,0.142962816881325,"ICA1L","islet cell autoantigen 1 like",TRUE
+"230454_at",0.976660494182006,0.88879703724937,-0.14144442369465,-5.92994373548273,-0.0617223484102523,"ICA1L","islet cell autoantigen 1 like",TRUE
+"215485_s_at",0.366473876333673,0.010814325510142,2.78247877654875,-2.74152682208761,1.93319521905636,"ICAM1","intercellular adhesion molecule 1",TRUE
+"202638_s_at",0.51531387545335,0.0357667839324719,2.23564841901572,-3.76057900961154,2.28234848821038,"ICAM1","intercellular adhesion molecule 1",TRUE
+"202637_s_at",0.538375019104427,0.0438774409717298,2.13706171335248,-3.93077969473243,2.06699908116613,"ICAM1","intercellular adhesion molecule 1",TRUE
+"204683_at",0.237644535895285,0.00310774290196852,3.3175704714779,-1.65450931481246,2.36933372895825,"ICAM2","intercellular adhesion molecule 2",TRUE
+"213620_s_at",0.500001415943741,0.0317330573996302,2.29253061914451,-3.6602750374835,2.88321269871349,"ICAM2","intercellular adhesion molecule 2",TRUE
+"204949_at",0.77204612088057,0.282394456031028,-1.10175158015235,-5.36514462708312,-0.621022845364271,"ICAM3","intercellular adhesion molecule 3",TRUE
+"207194_s_at",0.986889306520757,0.939295865532437,0.0770238748162653,-5.9367943054393,0.0457529735380673,"ICAM4","intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)",TRUE
+"206906_at",0.645072069975909,0.115499233089133,1.63822470407784,-4.71076979431642,1.24389640472052,"ICAM5","intercellular adhesion molecule 5",TRUE
+"209654_at",0.290359003667931,0.00502917195196215,3.11392186222387,-2.07599932212628,1.03384460162891,"ICE1","interactor of little elongation complex ELL subunit 1",TRUE
+"242639_at",0.801086839730802,0.337446027973522,-0.98045654499414,-5.48201388629353,-0.34568689702778,"ICE2","interactor of little elongation complex ELL subunit 2",TRUE
+"218713_at",0.932830928398943,0.703238086286268,-0.385917969785161,-5.86740305792305,-0.146368756200788,"ICE2","interactor of little elongation complex ELL subunit 2",TRUE
+"228960_at",0.980000734884886,0.904740413558803,-0.121052676645576,-5.93254869855996,-0.0593439480536544,"ICE2","interactor of little elongation complex ELL subunit 2",TRUE
+"235189_at",0.990810941805126,0.955103350491417,0.0569400237527749,-5.93810446445238,0.013311480323015,"ICE2","interactor of little elongation complex ELL subunit 2",TRUE
+"204569_at",0.0808717557112272,0.00027533682414551,-4.31557409139955,0.480940635302856,-2.38389375323514,"ICK","intestinal cell (MAK-like) kinase",TRUE
+"1552837_at",0.978928101156583,0.897488543797413,-0.130320845828097,-5.93141481691329,-0.117770588412286,"ICK","intestinal cell (MAK-like) kinase",TRUE
+"201610_at",0.792243446641505,0.323142589914078,1.01054663182088,-5.45416835340938,0.715334360542523,"ICMT","isoprenylcysteine carboxyl methyltransferase",TRUE
+"201609_x_at",0.816366892489054,0.367607734669968,0.919752507528314,-5.53584623956591,0.289065159810928,"ICMT","isoprenylcysteine carboxyl methyltransferase",TRUE
+"201611_s_at",0.993068096234107,0.966967705666417,-0.0418822426696897,-5.93882914858936,-0.0136053160276433,"ICMT","isoprenylcysteine carboxyl methyltransferase",TRUE
+"210439_at",0.82847108093969,0.398411319211454,0.861090224278111,-5.5848500227949,0.410109665013993,"ICOS","inducible T-cell costimulator",TRUE
+"211198_s_at",0.548504186940293,0.0484048047917131,2.08899799710926,-4.01200591798959,1.22849026592603,"ICOSLG","inducible T-cell costimulator ligand",TRUE
+"213450_s_at",0.590161029974676,0.0681424157700984,1.91760443271918,-4.29167402866083,1.21878302127961,"ICOSLG","inducible T-cell costimulator ligand",TRUE
+"211197_s_at",0.901154557823402,0.597541927046446,-0.535642542169996,-5.80089673399135,-0.447064445672336,"ICOSLG","inducible T-cell costimulator ligand",TRUE
+"228976_at",0.979347742195592,0.900387911907843,-0.126613985299559,-5.93187833753951,-0.124050244139998,"ICOSLG","inducible T-cell costimulator ligand",TRUE
+"211199_s_at",0.989638901366417,0.9500074127617,0.0634115266547074,-5.93772517908986,0.061162909019,"ICOSLG","inducible T-cell costimulator ligand",TRUE
+"208937_s_at",0.683254141963065,0.152326105997302,1.48237031573043,-4.92257510714999,1.45294709404249,"ID1","inhibitor of DNA binding 1, HLH protein",TRUE
+"201566_x_at",0.723360467478293,0.199935683239273,-1.32114331779709,-5.12353240202274,-1.41070253616456,"ID2","inhibitor of DNA binding 2, HLH protein",TRUE
+"201565_s_at",0.78969417320323,0.31772175869004,-1.02219222752964,-5.44318678477552,-1.12247848290456,"ID2","inhibitor of DNA binding 2, HLH protein",TRUE
+"229756_at",0.937623890519979,0.724032568043046,0.35759188876915,-5.87759295667576,0.108779830926036,"ID2-AS1","ID2 antisense RNA 1 (head to head)",TRUE
+"236719_at",0.962422974805316,0.828766319154712,-0.218855123840751,-5.91638123283578,-0.0919412587818726,"ID2-AS1","ID2 antisense RNA 1 (head to head)",TRUE
+"210911_at",0.587626678796111,0.0665369644923636,-1.92977185480173,-4.27235566395363,-1.66860221303093,"ID2B","inhibitor of DNA binding 2B, HLH protein (pseudogene)",TRUE
+"213931_at",0.615637099066718,0.0860605697965436,-1.79651639624364,-4.47921384452152,-1.86712290151032,"ID2B///ID2","inhibitor of DNA binding 2B, HLH protein (pseudogene)///inhibitor of DNA binding 2, HLH protein",TRUE
+"207826_s_at",0.635947583479864,0.10723000954917,1.67885355902224,-4.65286730447708,1.16041532191629,"ID3","inhibitor of DNA binding 3, HLH protein",TRUE
+"209291_at",0.598790786356002,0.0757328684266418,1.8632751894914,-4.37689086820722,2.55579229706217,"ID4","inhibitor of DNA binding 4, HLH protein",TRUE
+"226933_s_at",0.623503825356688,0.0942890975316944,1.7481154788926,-4.55170092109586,1.80512897771367,"ID4","inhibitor of DNA binding 4, HLH protein",TRUE
+"209293_x_at",0.661974206478491,0.129378289910641,1.57521687279316,-4.7983984474827,1.22758831918059,"ID4","inhibitor of DNA binding 4, HLH protein",TRUE
+"209292_at",0.682825347106105,0.151089548226605,1.48707038858288,-4.91643399209686,1.76305037083875,"ID4","inhibitor of DNA binding 4, HLH protein",TRUE
+"229386_at",0.913299709879835,0.636335291650912,0.479423918478543,-5.82834918096716,0.206704470130806,"ID4","inhibitor of DNA binding 4, HLH protein",TRUE
+"203327_at",0.930374550176682,0.692162789934137,-0.401135390917269,-5.86161279592516,-0.124422924791038,"IDE","insulin degrading enzyme",TRUE
+"203328_x_at",0.93174221209471,0.698678731567398,0.392171071947434,-5.86505043815629,0.123108822574293,"IDE","insulin degrading enzyme",TRUE
+"217496_s_at",0.995375928428862,0.978420736743112,-0.0273559456467636,-5.93931899471868,-0.0104923263056147,"IDE","insulin degrading enzyme",TRUE
+"1555037_a_at",0.898609426925686,0.588106502896378,-0.549577366922708,-5.7936343598335,-0.30313327622218,"IDH1","isocitrate dehydrogenase (NADP(+)) 1, cytosolic",TRUE
+"242956_at",0.949495693037756,0.771755461009186,0.293653906218071,-5.89776981034072,0.151422218470078,"IDH1","isocitrate dehydrogenase (NADP(+)) 1, cytosolic",TRUE
+"201193_at",0.966064677476069,0.841973735913848,-0.201723141212661,-5.91988321051008,-0.104541117787972,"IDH1","isocitrate dehydrogenase (NADP(+)) 1, cytosolic",TRUE
+"236400_at",0.426884347674613,0.0183425444854789,-2.54633808633831,-3.19565339846346,-1.28120252872115,"IDH1-AS1","IDH1 antisense RNA 1",TRUE
+"210046_s_at",0.820611742812032,0.381143920490455,-0.893592256713323,-5.55806856904109,-0.801865995853767,"IDH2","isocitrate dehydrogenase (NADP(+)) 2, mitochondrial",TRUE
+"210045_at",0.870517518639056,0.509533134903477,-0.670396294009407,-5.72312134171654,-0.373415792924886,"IDH2","isocitrate dehydrogenase (NADP(+)) 2, mitochondrial",TRUE
+"202069_s_at",0.73223722457785,0.216355946352083,-1.27259112456817,-5.18024772157569,-0.531286247638906,"IDH3A","isocitrate dehydrogenase 3 (NAD(+)) alpha",TRUE
+"231137_at",0.779813064835198,0.301014261240912,1.05898773183692,-5.40774450884209,0.633428081078019,"IDH3A","isocitrate dehydrogenase 3 (NAD(+)) alpha",TRUE
+"202070_s_at",0.913123070637484,0.635208260532707,-0.48103442555547,-5.82760406751465,-0.226890729893721,"IDH3A","isocitrate dehydrogenase 3 (NAD(+)) alpha",TRUE
+"201509_at",0.723009970036937,0.199789892037732,-1.32158805554665,-5.12300458729195,-0.661421504425467,"IDH3B","isocitrate dehydrogenase 3 (NAD(+)) beta",TRUE
+"210418_s_at",0.841967750949524,0.434811221332798,-0.795414753173562,-5.63613678021484,-0.323123696682787,"IDH3B","isocitrate dehydrogenase 3 (NAD(+)) beta",TRUE
+"210014_x_at",0.894729774938685,0.571811284842298,-0.573906967064217,-5.78052073648233,-0.195723255331439,"IDH3B","isocitrate dehydrogenase 3 (NAD(+)) beta",TRUE
+"202471_s_at",0.55679801038721,0.0520349959481715,-2.05329176864168,-4.07157624233149,-0.695346363664358,"IDH3G","isocitrate dehydrogenase 3 (NAD(+)) gamma",TRUE
+"214333_x_at",0.841967750949524,0.434962045096824,-0.795149929806711,-5.63633586039053,-0.276401779621709,"IDH3G","isocitrate dehydrogenase 3 (NAD(+)) gamma",TRUE
+"208881_x_at",0.819018525257656,0.37427049671781,-0.906797793550999,-5.54692487406984,-0.396395346112392,"IDI1","isopentenyl-diphosphate delta isomerase 1",TRUE
+"204615_x_at",0.854184492233394,0.46465480366785,-0.744066416876432,-5.67356711559627,-0.325373287921705,"IDI1","isopentenyl-diphosphate delta isomerase 1",TRUE
+"233014_at",0.890405697398587,0.558997266816763,0.593287030978287,-5.76968138525797,0.214244354945785,"IDI1","isopentenyl-diphosphate delta isomerase 1",TRUE
+"242065_x_at",0.976371465776674,0.886856923673428,-0.143929869094477,-5.92959860898625,-0.04970881798981,"IDI1","isopentenyl-diphosphate delta isomerase 1",TRUE
+"1552491_at",0.95168059103032,0.778356519034677,-0.284913538126629,-5.90022293677012,-0.176892027304213,"IDI2","isopentenyl-diphosphate delta isomerase 2",TRUE
+"220703_at",0.932633693661011,0.702611343273352,0.386776606793035,-5.86708221823576,0.145193563940263,"IDI2-AS1","IDI2 antisense RNA 1",TRUE
+"228002_at",0.87538158011492,0.522655566863147,0.649557651530838,-5.73624264257506,0.273471560206296,"IDI2///GTPBP4","isopentenyl-diphosphate delta isomerase 2///GTP binding protein 4",TRUE
+"227865_at",0.610033432202476,0.0822696973709192,-1.8201706322345,-4.4432651188503,-1.4621097431648,"IDNK","IDNK, gluconokinase",TRUE
+"239086_at",0.984515877561407,0.92445633190482,-0.0959073486365351,-5.9352043599973,-0.0706163770506869,"IDNK","IDNK, gluconokinase",TRUE
+"210029_at",0.929786324276714,0.690164547886234,0.403891156740834,-5.86054064012695,0.287278636824301,"IDO1","indoleamine 2,3-dioxygenase 1",TRUE
+"1568638_a_at",0.88587213211399,0.547796224041995,0.610417207535945,-5.75981084904358,0.291164904072398,"IDO2","indoleamine 2,3-dioxygenase 2",TRUE
+"211782_at",0.85334340854827,0.460837682826583,0.750520912722051,-5.66899186166667,0.415211400993856,"IDS","iduronate 2-sulfatase",TRUE
+"217432_s_at",0.895457620469779,0.574292617798485,0.57017991390788,-5.78256533029525,0.25673668693368,"IDS","iduronate 2-sulfatase",TRUE
+"236823_at",0.899423459651693,0.590195937595197,0.546482155565338,-5.79526314029544,0.410369326998445,"IDS","iduronate 2-sulfatase",TRUE
+"212223_at",0.927538966917087,0.682332780765837,-0.41472289351816,-5.85625646253012,-0.217952424374193,"IDS","iduronate 2-sulfatase",TRUE
+"202438_x_at",0.929088231432081,0.6877003659252,-0.407293887974814,-5.85920680786043,-0.229515971375409,"IDS","iduronate 2-sulfatase",TRUE
+"213821_s_at",0.966593471043185,0.844255391944132,-0.19876988642725,-5.9204581768624,-0.125810792424652,"IDS","iduronate 2-sulfatase",TRUE
+"210666_at",0.976909946655349,0.890128282782978,-0.139739517064503,-5.93017700756758,-0.0797106910750918,"IDS","iduronate 2-sulfatase",TRUE
+"202439_s_at",0.991367768700244,0.959671924951093,0.0511403632296319,-5.93840972692496,0.0305104618656067,"IDS","iduronate 2-sulfatase",TRUE
+"212221_x_at",0.992869121264064,0.966318923876737,-0.042705362594572,-5.93879523938071,-0.0233500468212426,"IDS","iduronate 2-sulfatase",TRUE
+"206342_x_at",0.996261754016157,0.981690112980302,0.0232105230599022,-5.9394210894241,0.0151173343379316,"IDS","iduronate 2-sulfatase",TRUE
+"205059_s_at",0.597654932724127,0.0750853540536265,-1.86771938346794,-4.36998473542782,-0.863639804701443,"IDUA","iduronidase, alpha-L-",TRUE
+"205057_s_at",0.734523729336291,0.218778581293855,-1.26567101054543,-5.18818403469284,-0.982566103630461,"IDUA","iduronidase, alpha-L-",TRUE
+"213723_s_at",0.961212424803935,0.823423871238693,-0.225803851467218,-5.9148798766679,-0.115446534892397,"IDUA","iduronidase, alpha-L-",TRUE
+"202081_at",0.998507818207624,0.993741278828526,-0.00793320862777808,-5.93965282708825,-0.00308269830463992,"IER2","immediate early response 2",TRUE
+"201631_s_at",0.675447258877226,0.141775371119858,1.52351949182208,-4.86828088884448,1.11234204286283,"IER3","immediate early response 3",TRUE
+"223071_at",0.62986301194198,0.100876121798281,-1.71191411868635,-4.60495964507101,-0.598893878871275,"IER3IP1","immediate early response 3 interacting protein 1",TRUE
+"211406_at",0.973493137611142,0.872165503446893,-0.162782126749233,-5.92678550698188,-0.0508523259912437,"IER3IP1","immediate early response 3 interacting protein 1",TRUE
+"218611_at",0.744307803443383,0.235213656621246,1.22021038458261,-5.23939546294992,0.785049457592406,"IER5","immediate early response 5",TRUE
+"226552_at",0.730583674018334,0.213229880427092,-1.28160920464691,-5.16984994535969,-0.941670463509994,"IER5L","immediate early response 5 like",TRUE
+"226559_at",0.932091525948902,0.700207243076214,-0.390072974563692,-5.86584396440324,-0.178857734682037,"IER5L","immediate early response 5 like",TRUE
+"36030_at",0.62986301194198,0.100868460773158,1.71195503609582,-4.60489991754179,0.660953612678451,"IFFO1","intermediate filament family orphan 1",TRUE
+"209721_s_at",0.788413816943444,0.31464628224671,1.02886123607532,-5.43684684825032,0.723365024353765,"IFFO1","intermediate filament family orphan 1",TRUE
+"225615_at",0.869441836317963,0.506626636269815,0.675052165332559,-5.72013547955372,0.361611991002059,"IFFO2","intermediate filament family orphan 2",TRUE
+"208965_s_at",0.331700023364203,0.00809305589698851,2.9092504801161,-2.49042067087023,5.45964811962233,"IFI16","interferon gamma inducible protein 16",TRUE
+"208966_x_at",0.378268072695715,0.0116092149242508,2.75118287779311,-2.80277876390133,4.759067717221,"IFI16","interferon gamma inducible protein 16",TRUE
+"206332_s_at",0.384135218769668,0.0123593071392315,2.72345981830184,-2.85677970143964,5.42203426562884,"IFI16","interferon gamma inducible protein 16",TRUE
+"202411_at",0.291577372893441,0.0051256188022455,3.10582035591545,-2.09259243693496,5.02921616582104,"IFI27","interferon alpha inducible protein 27",TRUE
+"230172_at",0.997654912087849,0.988284436771412,-0.0148504073199012,-5.93957606704849,-0.00688366238334304,"IFI27L1","interferon alpha inducible protein 27 like 1",TRUE
+"223626_x_at",0.641112145892678,0.111629856708193,1.65691967079886,-4.6842608873316,1.16495401168138,"IFI27L2","interferon alpha inducible protein 27 like 2",TRUE
+"201422_at",0.81836001261482,0.371564736168501,0.912040133306573,-5.5424591823778,0.581263897544027,"IFI30///PIK3R2","IFI30, lysosomal thiol reductase///phosphoinositide-3-kinase regulatory subunit 2",TRUE
+"209417_s_at",0.784498961298069,0.307735788940314,1.04401532235434,-5.422302364875,1.1348152184486,"IFI35","interferon induced protein 35",TRUE
+"214453_s_at",0.258009532763673,0.0038142171965035,3.23127480121114,-1.83409375731353,3.12944700217605,"IFI44","interferon induced protein 44",TRUE
+"214059_at",0.622434989367596,0.0929336040359546,1.75583231052801,-4.54024135027976,1.51787257230538,"IFI44","interferon induced protein 44",TRUE
+"204439_at",0.552281323843226,0.0494875110608706,2.07810437157848,-4.03025087186434,3.28420020668863,"IFI44L","interferon induced protein 44 like",TRUE
+"204415_at",0.705740389674391,0.178155077426355,1.39060790173695,-5.03929228748207,1.35447650619179,"IFI6","interferon alpha inducible protein 6",TRUE
+"1555464_at",0.582175577426224,0.0642496101360738,1.94756142422433,-4.24395958825276,0.917474237249619,"IFIH1","interferon induced with helicase C domain 1",TRUE
+"219209_at",0.807528762746328,0.348848373544637,0.957091821846893,-5.50310652133655,1.17719924921532,"IFIH1","interferon induced with helicase C domain 1",TRUE
+"216020_at",0.82064687791745,0.381571219183753,0.892776499892724,-5.55875199854815,0.872047192788034,"IFIH1","interferon induced with helicase C domain 1",TRUE
+"203153_at",0.481218714024581,0.0272536752871653,2.36404850520571,-3.53208927002168,2.83463752737534,"IFIT1","interferon induced protein with tetratricopeptide repeats 1",TRUE
+"217502_at",0.358427723880268,0.00998845256019317,2.81739802228432,-2.67282848052362,2.14698308889999,"IFIT2","interferon induced protein with tetratricopeptide repeats 2",TRUE
+"226757_at",0.384135218769668,0.0124625030889587,2.71977102261768,-2.86394636457956,2.9531091293976,"IFIT2","interferon induced protein with tetratricopeptide repeats 2",TRUE
+"229450_at",0.425751189365875,0.0182685198802451,2.54817405393013,-3.19219837811528,3.01876973074478,"IFIT3","interferon induced protein with tetratricopeptide repeats 3",TRUE
+"204747_at",0.487765518929235,0.02886417270267,2.33716880858106,-3.58053198142515,1.83171547372972,"IFIT3","interferon induced protein with tetratricopeptide repeats 3",TRUE
+"203595_s_at",0.595997098747707,0.0725649494565465,1.88534296543872,-4.34248408933797,1.11272405290455,"IFIT5","interferon induced protein with tetratricopeptide repeats 5",TRUE
+"203596_s_at",0.768852835478002,0.273181237455148,1.12366884363915,-5.34273053289716,0.98257140498479,"IFIT5","interferon induced protein with tetratricopeptide repeats 5",TRUE
+"214022_s_at",0.758722841981575,0.255823009142642,1.16647941916707,-5.29782705267125,1.61705033397679,"IFITM1","interferon induced transmembrane protein 1",TRUE
+"227886_at",0.536559328842429,0.0434340289377723,-2.14200640976268,-3.92235688382846,-1.33710749772451,"IFITM10","interferon induced transmembrane protein 10",TRUE
+"1564573_at",0.547793752989355,0.0482582796830769,-2.09048900939858,-4.00950394014401,-2.28044973086375,"IFITM10","interferon induced transmembrane protein 10",TRUE
+"227863_at",0.62524538993269,0.0965714516559902,-1.73533407789063,-4.57059925079855,-1.6242466264826,"IFITM10","interferon induced transmembrane protein 10",TRUE
+"201315_x_at",0.913342687538603,0.636779098300734,0.478790079858415,-5.82864176105747,0.728659844913862,"IFITM2","interferon induced transmembrane protein 2",TRUE
+"201601_x_at",0.738061563377262,0.224973157850238,1.24823999971491,-5.20801041924101,2.07210869248873,"IFITM2///IFITM1","interferon induced transmembrane protein 2///interferon induced transmembrane protein 1",TRUE
+"212203_x_at",0.8115881531789,0.355806710526763,0.943087566997383,-5.51552579636984,1.67717949563875,"IFITM3","interferon induced transmembrane protein 3",TRUE
+"208375_at",0.988713664405312,0.945537173897203,-0.0690907097439535,-5.93735873957755,-0.0582961541942328,"IFNA1","interferon alpha 1",TRUE
+"208261_x_at",0.969829083058377,0.855595899795534,0.184117585804105,-5.92318586374408,0.0664957429121502,"IFNA10","interferon alpha 10",TRUE
+"208344_x_at",0.996296795497044,0.982133722791216,-0.0226480794642785,-5.93943365186527,-0.0137669067396367,"IFNA13///IFNA1","interferon alpha 13///interferon alpha 1",TRUE
+"208182_x_at",0.818637718131529,0.372142663494784,-0.91091829650963,-5.54341681796929,-0.50258444730402,"IFNA14","interferon alpha 14",TRUE
+"208448_x_at",0.972405051071295,0.866934580241011,-0.169508771904254,-5.92569826930938,-0.0667227775147632,"IFNA16","interferon alpha 16",TRUE
+"211405_x_at",0.953336155514097,0.785161903663462,0.275926282671449,-5.90266866086885,0.0864775003046709,"IFNA17","interferon alpha 17",TRUE
+"211338_at",0.767011398042819,0.268409011267226,-1.13523421307598,-5.33074560439585,-0.786683757083283,"IFNA2","interferon alpha 2",TRUE
+"211145_x_at",0.821745015752602,0.384657568048867,0.886902045824659,-5.56365646303674,0.442561233504216,"IFNA21","interferon alpha 21",TRUE
+"207964_x_at",0.606900628956089,0.0805100262403866,1.83147282980496,-4.42596897604444,1.35761167525289,"IFNA4","interferon alpha 4",TRUE
+"214569_at",0.99186228645105,0.962413979974107,-0.0476602873369871,-5.93857717595287,-0.0202195613914951,"IFNA5","interferon alpha 5",TRUE
+"208548_at",0.907830501915195,0.617357949551145,-0.506718653344438,-5.81539121028565,-0.400774914461989,"IFNA6///IFNA5","interferon alpha 6///interferon alpha 5",TRUE
+"208259_x_at",0.767727587789514,0.269938303217394,1.13151172326581,-5.33461496369799,0.825566531611192,"IFNA7","interferon alpha 7",TRUE
+"207932_at",0.918047479325634,0.65199791063835,0.457172609847754,-5.83839352233213,0.433609684025006,"IFNA8","interferon alpha 8",TRUE
+"204191_at",0.623667408398064,0.0952163763797412,1.74289103674255,-4.55943808960738,0.576359222129047,"IFNAR1","interferon alpha and beta receptor subunit 1",TRUE
+"236478_at",0.667641453131852,0.13403312664203,-1.55534457022115,-4.82547875582518,-0.514082672900457,"IFNAR1","interferon alpha and beta receptor subunit 1",TRUE
+"225661_at",0.790333400800316,0.319996435744877,1.01728875287956,-5.44782453723645,0.326794892417025,"IFNAR1","interferon alpha and beta receptor subunit 1",TRUE
+"225669_at",0.988224361618126,0.943980331750442,-0.0710691257879586,-5.93722371163619,-0.0293374925805612,"IFNAR1","interferon alpha and beta receptor subunit 1",TRUE
+"204786_s_at",0.8288884913487,0.39960960533536,0.85886885260939,-5.58664674667896,0.669088249170514,"IFNAR2","interferon alpha and beta receptor subunit 2",TRUE
+"227125_at",0.89767014756104,0.584794257657576,0.554495167921847,-5.79102811329946,0.287883139041934,"IFNAR2","interferon alpha and beta receptor subunit 2",TRUE
+"204785_x_at",0.99872918752906,0.994511601935743,-0.00695677206500221,-5.93965990853932,-0.00332986854542305,"IFNAR2","interferon alpha and beta receptor subunit 2",TRUE
+"208173_at",0.984810537070054,0.92555492344828,-0.0945082396340501,-5.9353340628678,-0.0318025187348114,"IFNB1","interferon beta 1",TRUE
+"1553574_at",0.496847720880538,0.0303929618713792,2.31289976502664,-3.62399729670513,0.826265854100421,"IFNE","interferon epsilon",TRUE
+"210354_at",0.949248641452491,0.770944415614044,-0.294729398913602,-5.89746287656273,-0.218029753430782,"IFNG","interferon gamma",TRUE
+"211676_s_at",0.308621629697291,0.00632126426908892,3.01602683698126,-2.27549973722512,1.22397397721598,"IFNGR1","interferon gamma receptor 1",TRUE
+"202727_s_at",0.316105101277512,0.00683157710710519,2.98259446290925,-2.34310739465349,1.1794829970343,"IFNGR1","interferon gamma receptor 1",TRUE
+"242903_at",0.840616438821329,0.429775380215413,0.804289728629571,-5.62942900763408,0.411042057386047,"IFNGR1","interferon gamma receptor 1",TRUE
+"201642_at",0.67622507827427,0.142726460938224,1.51970923542911,-4.87335824100975,0.696420105863925,"IFNGR2","interferon gamma receptor 2 (interferon gamma transducer 1)",TRUE
+"224093_at",0.788413816943444,0.314675648244416,1.02879734157058,-5.43690776654554,1.09515284204181,"IFNK","interferon kappa",TRUE
+"1552917_at",0.731492530402354,0.214721798647185,-1.27729270181905,-5.17483465305228,-0.390230654125612,"IFNL1","interferon lambda 1",TRUE
+"1552915_at",0.784772264193483,0.30884215470784,1.0415731302681,-5.42465925891758,0.492659017538083,"IFNL2","interferon lambda 2",TRUE
+"1552609_s_at",0.606138724709726,0.0797118868926134,1.83666999422625,-4.41798981615784,1.72854657892029,"IFNL3///IFNL2","interferon lambda 3///interferon lambda 2",TRUE
+"244261_at",0.54295328972902,0.0459480396078171,2.11455156677549,-3.96896776958064,2.34785833330438,"IFNLR1","interferon lambda receptor 1",TRUE
+"1555499_a_at",0.716219454102037,0.191924907232608,1.34596555376896,-5.09384494383331,0.602892667307568,"IFNLR1","interferon lambda receptor 1",TRUE
+"207817_at",0.965992617204023,0.840976040151073,0.203015081190139,-5.91962902821909,0.098037965567439,"IFNW1","interferon omega 1",TRUE
+"202146_at",0.906291145374052,0.612962784906942,-0.513095386424577,-5.81226303202681,-0.254739934077204,"IFRD1","interferon related developmental regulator 1",TRUE
+"230048_at",0.91671872326659,0.647966557977982,-0.462876999356084,-5.8358630857203,-0.199223906964264,"IFRD1","interferon related developmental regulator 1",TRUE
+"202147_s_at",0.950566549545106,0.774870114857511,0.289526968795838,-5.89893726422139,0.135817264604878,"IFRD1","interferon related developmental regulator 1",TRUE
+"209100_at",0.856690614892852,0.470848775815184,-0.733659506925374,-5.68086510472171,-0.356594133974813,"IFRD2","interferon related developmental regulator 2",TRUE
+"216678_at",0.612420348961838,0.0840310951475778,1.80906516880917,-4.46018507062593,0.469685404886006,"IFT122","intraflagellar transport 122",TRUE
+"1563794_s_at",0.897949253801113,0.586442879835042,0.552045683083868,-5.79232906462412,0.256430478201188,"IFT122","intraflagellar transport 122",TRUE
+"232844_at",0.868397087637799,0.50327260805322,0.68044362377671,-5.71665317461211,0.349039573413235,"IFT140","intraflagellar transport 140",TRUE
+"244585_at",0.893395477698951,0.568116560523306,0.579471852470281,-5.77744392855472,0.290498471240521,"IFT140","intraflagellar transport 140",TRUE
+"204792_s_at",0.905953010541442,0.612468973546288,-0.513813177185318,-5.81190852327679,-0.185086785318384,"IFT140","intraflagellar transport 140",TRUE
+"226324_s_at",0.819479221404744,0.376729522891602,0.902055184028321,-5.55094438677712,0.34312277509393,"IFT172","intraflagellar transport 172",TRUE
+"210312_s_at",0.980019293742949,0.906089153976279,-0.119330156337923,-5.93275023368114,-0.0414591710048171,"IFT20","intraflagellar transport 20",TRUE
+"222742_s_at",0.757950630724418,0.254252332087509,-1.17045801171739,-5.29357911655127,-0.424380117302634,"IFT22","intraflagellar transport 22",TRUE
+"218785_s_at",0.767945391174396,0.27052291116763,-1.13009279909498,-5.33608691747208,-0.380083319411234,"IFT22","intraflagellar transport 22",TRUE
+"205037_at",0.332566035407083,0.008187026018758,-2.90423419036728,-2.50044366121978,-1.47968836084666,"IFT27","intraflagellar transport 27",TRUE
+"213784_at",0.853152340349922,0.459608485107383,-0.75260619304957,-5.66750571707236,-0.321879955146974,"IFT27","intraflagellar transport 27",TRUE
+"243812_at",0.962729263214086,0.830121781160766,-0.217093888830218,-5.91675434952983,-0.149389879033303,"IFT27","intraflagellar transport 27",TRUE
+"226196_s_at",0.308861881799719,0.00643503589110092,-3.00835434939262,-2.2910396985484,-0.99731025909189,"IFT43","intraflagellar transport 43",TRUE
+"226195_at",0.446963972064621,0.0211641658273756,-2.48105547104553,-3.31766904415877,-0.865424652934832,"IFT43","intraflagellar transport 43",TRUE
+"1568699_at",0.75224725515558,0.245575880334192,-1.19277218279754,-5.26952025891596,-0.492824593919868,"IFT43","intraflagellar transport 43",TRUE
+"218483_s_at",0.801086839730802,0.337204380614199,-0.980957514253444,-5.48155655334475,-0.318374980721671,"IFT46","intraflagellar transport 46",TRUE
+"218709_s_at",0.827866702343255,0.397345733934919,0.863069212082869,-5.58324570963737,0.350343007376958,"IFT52","intraflagellar transport 52",TRUE
+"233532_x_at",0.881466832418197,0.538262979828905,0.625143015470556,-5.75110918667026,0.195501246707965,"IFT52","intraflagellar transport 52",TRUE
+"222520_s_at",0.874609934757957,0.521054767350177,0.652084132207346,-5.73467298460824,0.679795599743644,"IFT57","intraflagellar transport 57",TRUE
+"218100_s_at",0.966051687342135,0.841229960085453,0.202686240779654,-5.91969387915794,0.243330184308608,"IFT57","intraflagellar transport 57",TRUE
+"222519_s_at",0.984244246588495,0.923280749709553,0.0974047262616628,-5.93506343759308,0.066695137102105,"IFT57","intraflagellar transport 57",TRUE
+"61732_r_at",0.237274974149108,0.00308989083848496,-3.31999035672677,-1.64945443916849,-1.03837789366386,"IFT74","intraflagellar transport 74",TRUE
+"219174_at",0.789503009592599,0.316505642612713,-1.02482387504649,-5.44068943881602,-0.476826780219862,"IFT74","intraflagellar transport 74",TRUE
+"226098_at",0.47984873377716,0.0269957136341933,2.36848931665171,-3.52405588993348,0.857062436439398,"IFT80","intraflagellar transport 80",TRUE
+"1558956_s_at",0.61810433367952,0.089002074578452,1.77877419000218,-4.5059534397601,0.777980245566958,"IFT80","intraflagellar transport 80",TRUE
+"240251_at",0.737978661762069,0.224703087854607,-1.24899225029089,-5.20715966517933,-0.879938542782655,"IFT80","intraflagellar transport 80",TRUE
+"1564231_at",0.921312278448293,0.664890781782467,0.439030922141329,-5.84623652832143,0.129078826654558,"IFT80","intraflagellar transport 80",TRUE
+"223736_at",0.692289844352812,0.161729648281008,1.4476064220181,-4.96750872652359,0.702424661111848,"IFT81","intraflagellar transport 81",TRUE
+"219372_at",0.924899007644533,0.675129755740161,-0.424729763356517,-5.85219946058639,-0.206617117832154,"IFT81","intraflagellar transport 81",TRUE
+"204703_at",0.849935057946582,0.452235694836801,-0.765184606128841,-5.65845857148112,-0.284368816346779,"IFT88","intraflagellar transport 88",TRUE
+"202105_at",0.802994404953081,0.340635378921241,0.973867515618346,-5.48800916761103,0.341114930062371,"IGBP1","immunoglobulin (CD79A) binding protein 1",TRUE
+"230960_at",0.787784580458053,0.313660868270068,-1.03100773298326,-5.43479835199003,-0.52725652675055,"IGDCC3","immunoglobulin superfamily DCC subclass member 3",TRUE
+"232037_at",0.978255630670068,0.894842836443184,-0.133705030737742,-5.93097998530357,-0.0545875252608905,"IGDCC3","immunoglobulin superfamily DCC subclass member 3",TRUE
+"227870_at",0.562894650172193,0.055530193302687,2.02095814015883,-4.12493839440148,1.30960173683789,"IGDCC4","immunoglobulin superfamily DCC subclass member 4",TRUE
+"241072_s_at",0.682539393883246,0.150368311039305,1.48982624080219,-4.91282591743196,0.851177596343469,"IGF1","insulin like growth factor 1",TRUE
+"209542_x_at",0.820288124919738,0.378643405138466,-0.898378076408242,-5.55404744487633,-0.611521957443689,"IGF1","insulin like growth factor 1",TRUE
+"211577_s_at",0.839508810008021,0.426157017249914,-0.810706508655471,-5.62453561728968,-0.555850586890053,"IGF1","insulin like growth factor 1",TRUE
+"209540_at",0.892278517390981,0.564514059352015,-0.584915680098439,-5.77440624552286,-0.357923295780184,"IGF1","insulin like growth factor 1",TRUE
+"209541_at",0.904381089098038,0.607839314989369,-0.520556105437974,-5.8085546885116,-0.341611843857899,"IGF1","insulin like growth factor 1",TRUE
+"208441_at",0.801837936177267,0.339373300019286,-0.976469824672538,-5.48564576000291,-0.549113416244245,"IGF1R","insulin like growth factor 1 receptor",TRUE
+"225330_at",0.939976205834042,0.729906358007109,-0.34964536667029,-5.88031388144877,-0.240891121471517,"IGF1R","insulin like growth factor 1 receptor",TRUE
+"243358_at",0.94514040407998,0.752608444918359,-0.31914164440983,-5.89019681744568,-0.276265939640416,"IGF1R","insulin like growth factor 1 receptor",TRUE
+"203627_at",0.955816406528307,0.798643200186335,0.258190287259448,-5.90726682616475,0.150576264096998,"IGF1R","insulin like growth factor 1 receptor",TRUE
+"203628_at",0.967777603239069,0.848493795061206,0.193288697287172,-5.9215029142146,0.164070197664213,"IGF1R","insulin like growth factor 1 receptor",TRUE
+"220561_at",0.951339758531576,0.777248030271776,0.286379671219776,-5.8998165751541,0.128686519684409,"IGF2-AS","IGF2 antisense RNA",TRUE
+"227377_at",0.699227912584377,0.170692180141997,1.41595946022906,-5.007657143573,1.35041538040475,"IGF2BP1","insulin like growth factor 2 mRNA binding protein 1",TRUE
+"241574_s_at",0.912906062613339,0.63464946718682,0.481833409672351,-5.82723350451598,0.414007489510236,"IGF2BP1","insulin like growth factor 2 mRNA binding protein 1",TRUE
+"223689_at",0.962259019699192,0.828185142935251,0.219610498368797,-5.91622028761788,0.146258724866645,"IGF2BP1","insulin like growth factor 2 mRNA binding protein 1",TRUE
+"218847_at",0.358427723880268,0.0100163896826446,2.81617265723352,-2.67524541240261,3.74828170442958,"IGF2BP2","insulin like growth factor 2 mRNA binding protein 2",TRUE
+"223963_s_at",0.414496551147683,0.0167239029141616,2.58816324591756,-3.11663417425011,1.33063876188,"IGF2BP2","insulin like growth factor 2 mRNA binding protein 2",TRUE
+"1562832_at",0.623503825356688,0.0943587622065993,1.74772145171129,-4.55228505502153,0.94310880523192,"IGF2BP2-AS1","IGF2BP2 antisense RNA 1",TRUE
+"1563208_s_at",0.756006545489432,0.250741034562928,1.1794188715567,-5.28396529653206,0.871314659425964,"IGF2BP2-AS1","IGF2BP2 antisense RNA 1",TRUE
+"1562694_at",0.774230543658252,0.289166169383504,1.08597083401742,-5.38104003097349,0.828236272435857,"IGF2BP2-AS1","IGF2BP2 antisense RNA 1",TRUE
+"1563207_at",0.831013183269159,0.404963463732337,0.848995805620844,-5.59458009658476,0.732464486780062,"IGF2BP2-AS1","IGF2BP2 antisense RNA 1",TRUE
+"216493_s_at",0.199181589554674,0.00219487288232742,3.46302713387458,-1.34900773292163,4.12915705773646,"IGF2BP3","insulin like growth factor 2 mRNA binding protein 3",TRUE
+"203820_s_at",0.250373992456606,0.00353498028910394,3.2633632043696,-1.76747443956398,4.98665264521578,"IGF2BP3","insulin like growth factor 2 mRNA binding protein 3",TRUE
+"203819_s_at",0.280199223932988,0.0046648586087739,3.14594065933572,-2.01028031441305,6.17854087460823,"IGF2BP3","insulin like growth factor 2 mRNA binding protein 3",TRUE
+"1569033_at",0.580630437263151,0.063122215950734,1.95653592315391,-4.229566590095,0.963366887075267,"IGF2BP3","insulin like growth factor 2 mRNA binding protein 3",TRUE
+"201392_s_at",0.402463840838386,0.0148565449177733,2.64141585112431,-3.01510885839562,1.08919040591338,"IGF2R","insulin like growth factor 2 receptor",TRUE
+"201393_s_at",0.637485146909712,0.108751964134461,1.67118176700238,-4.66388346401378,0.62315714249131,"IGF2R","insulin like growth factor 2 receptor",TRUE
+"1569052_at",0.865885012497452,0.496338279600332,0.691655063263267,-5.70932701792488,0.670545984586838,"IGF2R","insulin like growth factor 2 receptor",TRUE
+"215712_s_at",0.774230543658252,0.288715868892633,1.08701188389384,-5.37999771107616,0.43810348332585,"IGFALS","insulin like growth factor binding protein acid labile subunit",TRUE
+"237989_at",0.857148066512338,0.471947362080721,-0.731822164642251,-5.682143434366,-0.346413549773297,"IGFBP1","insulin like growth factor binding protein 1",TRUE
+"205302_at",0.947778780715578,0.762299906786144,0.306214876695392,-5.8941156771802,0.403286551087226,"IGFBP1","insulin like growth factor binding protein 1",TRUE
+"202718_at",0.310606917432451,0.00655583690383262,-3.00034913707645,-2.30723810809885,-4.36666873455388,"IGFBP2","insulin like growth factor binding protein 2",TRUE
+"212143_s_at",0.270441084903894,0.00422281302450987,3.18820760439045,-1.92319617393532,4.91649922501764,"IGFBP3","insulin like growth factor binding protein 3",TRUE
+"210095_s_at",0.290601419869853,0.0050652611456053,3.11087296576058,-2.08224562204708,5.20987521202193,"IGFBP3","insulin like growth factor binding protein 3",TRUE
+"201508_at",0.999926228509198,0.999862611902775,-0.000174143641442404,-5.93968346597843,-0.000327294231949438,"IGFBP4","insulin like growth factor binding protein 4",TRUE
+"1555997_s_at",0.255831879596455,0.0037310552275136,-3.24058630846157,-1.81478185060532,-5.18140979135046,"IGFBP5","insulin like growth factor binding protein 5",TRUE
+"211959_at",0.280199223932988,0.00467621044441609,-3.14490703542561,-2.01240527113631,-5.86503138102699,"IGFBP5","insulin like growth factor binding protein 5",TRUE
+"211958_at",0.364251956492248,0.0105927866634234,-2.79159028158461,-2.72363695553168,-4.06092403248415,"IGFBP5","insulin like growth factor binding protein 5",TRUE
+"203424_s_at",0.402799969339577,0.0149051863235462,-2.63995075113276,-3.01791543661086,-5.06146703867262,"IGFBP5","insulin like growth factor binding protein 5",TRUE
+"203426_s_at",0.46584896273628,0.0242573753435791,-2.41821008520275,-3.43353943338479,-3.22079819370478,"IGFBP5","insulin like growth factor binding protein 5",TRUE
+"203425_s_at",0.552420073963858,0.0498118784867536,-2.07488234167448,-4.03563538834725,-2.81320655239816,"IGFBP5","insulin like growth factor binding protein 5",TRUE
+"203851_at",0.134365850976746,0.000853514943413004,3.85317255869193,-0.516884070203703,4.2840353661555,"IGFBP6","insulin like growth factor binding protein 6",TRUE
+"201162_at",0.499435312830389,0.031587044082741,2.2947113057942,-3.65640014378963,5.71143078747614,"IGFBP7","insulin like growth factor binding protein 7",TRUE
+"201163_s_at",0.54344488073991,0.0463355016278375,2.1104410972731,-3.97591334524868,4.69609445010269,"IGFBP7","insulin like growth factor binding protein 7",TRUE
+"213910_at",0.820536502908875,0.380162702650451,0.895467776016388,-5.55649509483127,1.01914974817121,"IGFBP7","insulin like growth factor binding protein 7",TRUE
+"1557395_at",0.892746695408886,0.565769764073474,0.583016135988275,-5.77546932296508,0.55055856482861,"IGFBP7-AS1","IGFBP7 antisense RNA 1",TRUE
+"227760_at",0.809930331505913,0.353661918749806,0.947384248467605,-5.51173324595316,0.737705986229675,"IGFBPL1","insulin like growth factor binding protein like 1",TRUE
+"239430_at",0.40221114169538,0.0145632496652146,2.6503468888042,-2.99798426317655,1.98739255707863,"IGFL1","IGF like family member 1",TRUE
+"231148_at",0.185392143728903,0.00181761493283484,3.5414326430591,-1.18307694226312,1.86145514749083,"IGFL2","IGF like family member 2",TRUE
+"219690_at",0.594005743610726,0.0708934478597009,-1.89732826264611,-4.32367814796648,-0.735949551666995,"IGFLR1","IGF like family receptor 1",TRUE
+"229275_at",0.625490878792938,0.0967036927011743,1.73460146323745,-4.57167936400385,1.34811030826112,"IGFN1","immunoglobulin-like and fibronectin type III domain containing 1",TRUE
+"1563098_at",0.712948021516228,0.186929328638082,1.3618597477634,-5.0745924023055,1.01910940440394,"IGFN1","immunoglobulin-like and fibronectin type III domain containing 1",TRUE
+"217469_at",0.727024029103545,0.207143673074989,-1.29946367409405,-5.14907965941003,-1.20473627937376,"IGH","immunoglobulin heavy locus",TRUE
+"211693_at",0.757950630724418,0.254498222289546,1.16983395742516,-5.2942462555017,0.379284459685624,"IGH","immunoglobulin heavy locus",TRUE
+"215118_s_at",0.774360462422895,0.290528617799645,1.08282807888681,-5.38418121625725,0.480674064866377,"IGH","immunoglobulin heavy locus",TRUE
+"1558438_a_at",0.820998335524177,0.381856198854684,-0.892232777617394,-5.55920720046322,-0.615722601636183,"IGH","immunoglobulin heavy locus",TRUE
+"216318_at",0.786455312223125,0.312147809787112,1.03431283411364,-5.43163662118878,0.448983897226327,"IGHA2///IGHA1///IGH","immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"217022_s_at",0.944850801239076,0.7519411330183,0.320033744799548,-5.88992045077494,0.220428197119084,"IGHA2///IGHA1///IGH","immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"215621_s_at",0.826974115143008,0.395244049119386,-0.866982481078603,-5.58006324136518,-0.579597282292928,"IGHD","immunoglobulin heavy constant delta",TRUE
+"222285_at",0.835838027302116,0.415441077496561,0.829912302333123,-5.60967164362304,0.516231611386751,"IGHD","immunoglobulin heavy constant delta",TRUE
+"213674_x_at",0.855075448726859,0.467388924185897,0.739462568442019,-5.67680765361975,0.332321663845339,"IGHD","immunoglobulin heavy constant delta",TRUE
+"214973_x_at",0.867099100798202,0.498863814582545,0.687561539846464,-5.71201520387895,0.321324017814026,"IGHD","immunoglobulin heavy constant delta",TRUE
+"230877_at",0.99886461451188,0.995012380647852,-0.00632200500582853,-5.93966401395174,-0.0029642565378798,"IGHD","immunoglobulin heavy constant delta",TRUE
+"216892_at",0.789795896476304,0.318212834528467,1.02113155090344,-5.44419169121763,0.629923416043347,"IGHG1","immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"231668_x_at",0.91876780831279,0.655090093279677,-0.452807576139755,-5.84030905796837,-0.335714516046055,"IGHG1","immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"217222_at",0.987625753339232,0.94153708183666,-0.0741745672585557,-5.93700407971935,-0.0414075501152471,"IGHG1","immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"217198_x_at",0.97070558355376,0.860523349439459,0.177764186763429,-5.92430394415243,0.0973592022951788,"IGHG1///IGHD///IGHA2///IGH","immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy locus",TRUE
+"215949_x_at",0.677013732819214,0.144250250707169,1.51364780911744,-4.88141448867817,1.11966956735118,"IGHM","immunoglobulin heavy constant mu",TRUE
+"211634_x_at",0.714820080026392,0.190574574628304,1.35022941141564,-5.08869871279123,0.351647153204687,"IGHM","immunoglobulin heavy constant mu",TRUE
+"212827_at",0.884729701742031,0.544090562256499,-0.616124940608576,-5.75646180704957,-0.293004402510133,"IGHM","immunoglobulin heavy constant mu",TRUE
+"209374_s_at",0.901788521024914,0.599414232094045,0.5328902054046,-5.80230971233621,0.323765196764648,"IGHM","immunoglobulin heavy constant mu",TRUE
+"216491_x_at",0.905934790589647,0.612337769367025,-0.514003937978994,-5.81181422741658,-0.395740952214688,"IGHM","immunoglobulin heavy constant mu",TRUE
+"216541_x_at",0.55937703282623,0.0536076300258967,2.03851108779677,-4.09603897512815,1.33512252663537,"IGHM///IGHG1","immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"211647_x_at",0.700061364939874,0.171906894403988,1.4117735227325,-5.01291305097111,1.06787077431749,"IGHM///IGHG1","immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"211640_x_at",0.809930331505913,0.353551882636615,0.947605158697701,-5.51153782799202,0.381737111649104,"IGHM///IGHG1","immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"211648_at",0.931370027472813,0.695655361877591,-0.396326366623337,-5.86346647758259,-0.29736867774672,"IGHM///IGHG1","immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"217169_at",0.387357699611418,0.0128143836158165,-2.70740639777061,-2.88793626198812,-1.56571441158935,"IGHM///IGHG1///IGHA1","immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"216542_x_at",0.649010621432137,0.119841621716872,1.61786081702347,-4.73938203431872,0.636062190397868,"IGHM///IGHG1///IGHA1","immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"211649_x_at",0.831025767174474,0.405063314041147,0.848812467922707,-5.59472660640462,0.343181468730012,"IGHM///IGHG1///IGHA1","immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"211632_at",0.784918343662568,0.309448934326215,-1.04023634916995,-5.42594724661785,-0.699373081384039,"IGHM///IGHG1///IGHD","immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta",TRUE
+"215980_s_at",0.915939421175188,0.645182352600221,0.4668257782209,-5.83409342720152,0.214427257272961,"IGHMBP2","immunoglobulin mu binding protein 2",TRUE
+"243746_at",0.980832655742,0.910010488474816,0.114324172666482,-5.93331956197504,0.0488185619741666,"IGHMBP2","immunoglobulin mu binding protein 2",TRUE
+"31861_at",0.981848698003052,0.913123778620195,0.110351876437652,-5.93375399165096,0.0474410908646306,"IGHMBP2","immunoglobulin mu binding protein 2",TRUE
+"240915_at",0.84176002413858,0.43365972223679,-0.79743848058996,-5.63461339054661,-0.526919165531174,"IGHV1-69","immunoglobulin heavy variable 1-69",TRUE
+"216510_x_at",0.693742297578797,0.162777504414594,1.44383464141755,-4.97233178136144,1.04780380299263,"IGHV3-23///IGHV4-31///IGHM///IGHG1///IGHA1","immunoglobulin heavy variable 3-23///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"217084_at",0.801086839730802,0.337071612410068,0.981232866568232,-5.48130509463128,0.42790618149732,"IGHV3-23///IGHV4-31///IGHM///IGHG1///IGHA1","immunoglobulin heavy variable 3-23///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"214916_x_at",0.683805950121197,0.152587446358424,-1.48138095448825,-4.92386581026305,-0.954658134776098,"IGHV3-23///IGHV4-31///IGHM///IGHG3///IGHG1///IGHA2///IGHA1","immunoglobulin heavy variable 3-23///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"211650_x_at",0.995111934465262,0.977347579911416,0.028716763900877,-5.93928183088897,0.0133212513142871,"IGHV3-23///IGHV4-31///IGHM///IGHG3///IGHG1///IGHD///IGHA1///IGH","immunoglobulin heavy variable 3-23///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"211637_x_at",0.967098812766994,0.846540717393856,0.195813694015372,-5.92102525487374,0.146140419223428,"IGHV3-23///IGHV4-31///IGHM///IGHG4///IGHG3///IGHG1///IGHD///IGHA2///IGHA1///IGH","immunoglobulin heavy variable 3-23///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 4 (G4m marker)///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"217083_at",0.384135218769668,0.0124385789289771,2.72062362567027,-2.86229030336524,0.85353340456079,"IGHV3-75","immunoglobulin heavy variable 3-75 (pseudogene)",TRUE
+"234477_at",0.773887727472977,0.285462540568319,1.09456825007452,-5.37240545993152,0.859019583871997,"IGHV4-31///IGHA1","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant alpha 1",TRUE
+"234792_x_at",0.908709061737317,0.620652435236244,0.501952776768727,-5.81770424354075,0.221752653705549,"IGHV4-31///IGHA1","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant alpha 1",TRUE
+"1561937_x_at",0.647518308302168,0.118361738557242,1.62473029871547,-4.72976090695597,0.896582540719465,"IGHV4-31///IGHM///IGHG1///IGHA1","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"217360_x_at",0.627092759817312,0.0986457843150836,1.72393966834065,-4.58735993432868,1.26166924350334,"IGHV4-31///IGHM///IGHG3///IGHG1///IGHA1","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"216557_x_at",0.819018525257656,0.374015425230769,0.907290914999811,-5.54650582068175,0.654632089951476,"IGHV4-31///IGHM///IGHG3///IGHG1///IGHD///IGHA1","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 1",TRUE
+"211641_x_at",0.89316156038085,0.566948925312749,0.58123435102377,-5.77646345493763,0.276007798967544,"IGHV4-31///IGHM///IGHG3///IGHG1///IGHD///IGHA2///IGHA1","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"211638_at",0.850693751204364,0.453516364855172,-0.762990896762026,-5.66004662571582,-0.547688515202414,"IGHV4-31///IGHM///IGHG3///IGHG1///IGHD///IGHA2///IGHA1///IGH","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"216558_x_at",0.969882914559333,0.856295174682688,0.183215482337142,-5.92334700101599,0.135021978861508,"IGHV4-31///IGHM///IGHG3///IGHG2///IGHG1///IGHD///IGHA1","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 2 (G2m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 1",TRUE
+"211868_x_at",0.847797601020174,0.447178286417204,-0.773884562915022,-5.65211816229657,-0.501263506170062,"IGHV4-31///IGHM///IGHG3///IGHG2///IGHG1///IGHD///IGHA2///IGHA1///IGH","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 2 (G2m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"211635_x_at",0.539609110035715,0.0444657899639115,2.13056987049627,-3.9418192686092,1.04135646838683,"IGHV4-31///IGHM///IGHG4///IGHG3///IGHG1///IGHD///IGHA2///IGHA1","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 4 (G4m marker)///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"211639_x_at",0.710672261019989,0.183747863498281,1.37215757485324,-5.06201807867625,1.05024857817939,"IGHV4-31///IGHM///IGHG4///IGHG3///IGHG1///IGHD///IGHA2///IGHA1///IGH","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 4 (G4m marker)///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"217236_x_at",0.875279162021058,0.522522828084181,0.649766986244893,-5.7361128088526,0.314916476293867,"IGHV4-31///IGHM///IGHG4///IGHG3///IGHG1///IGHD///IGHA2///IGHA1///IGH","immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 4 (G4m marker)///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant delta///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"210450_at",0.642021982677251,0.112336008691881,1.65346760980424,-4.68917311777671,1.22704628624957,"IGHV5-78","immunoglobulin heavy variable 5-78 (pseudogene)",TRUE
+"1555179_at",0.721809763133485,0.197948158910352,1.32722822340216,-5.11629784951888,0.932704142958822,"IGHV7-81","immunoglobulin heavy variable 7-81 (non-functional)",TRUE
+"226977_at",0.931528703027792,0.697337606088975,-0.394013432231233,-5.86435017657174,-0.174347169479069,"IGIP","IgA inducing protein",TRUE
+"241874_at",0.932041542202378,0.699555350111733,0.390967570976322,-5.86550612996376,0.136086032495116,"IGIP","IgA inducing protein",TRUE
+"215906_at",0.84204847460846,0.435263864142698,0.794620151991191,-5.63673393212759,0.602141955282445,"Igk","immunoglobulin kappa chain complex",TRUE
+"211908_x_at",0.936143408699214,0.715103760142715,0.369716776044425,-5.8733249952473,0.244479073971385,"IGK","immunoglobulin kappa locus",TRUE
+"211644_x_at",0.554642754132296,0.0511548819096362,2.06173874804866,-4.05754412477769,0.751189496399101,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"224795_x_at",0.606900628956089,0.0806121933601605,1.83081079050261,-4.42698423595785,0.821715783862225,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"216829_at",0.790240875783718,0.319771736012644,-1.01777204605905,-5.4473683297366,-0.722586982264521,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"221671_x_at",0.816800680706682,0.36803605944515,0.918915027861651,-5.53656681693771,0.345019885597685,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"211643_x_at",0.820293495506061,0.379161339779295,0.897385082181341,-5.55488340845934,0.458492939486266,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"217157_x_at",0.839519981963042,0.426441232855513,0.810201257957549,-5.6249222416517,0.470738525160915,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"217145_at",0.864079461576774,0.490835122421287,0.700616251689023,-5.70338911412516,0.448682799262992,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"216576_x_at",0.903383391791809,0.603481124667527,0.526926052969148,-5.80534724669968,0.19711874960552,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"221651_x_at",0.942303845415102,0.740865393742277,0.334879808489934,-5.88520915962198,0.150725996883189,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"214836_x_at",0.962555471240652,0.829078559706016,0.218449347962005,-5.91646746229277,0.110919431075238,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"215176_x_at",0.98539961718117,0.9280070160226,-0.0913860749013115,-5.93561663304151,-0.055188804764339,"IGK///IGKC","immunoglobulin kappa locus///immunoglobulin kappa constant",TRUE
+"215217_at",0.120707971532788,0.000673359511979885,-3.95034088896473,-0.307745428387857,-1.46928614048837,"IGKC","immunoglobulin kappa constant",TRUE
+"211146_at",0.585036027492332,0.0655283705839822,1.9375485710085,-4.25996434248065,0.878018239279741,"IGKC","immunoglobulin kappa constant",TRUE
+"211835_at",0.589598952558101,0.0678618419469251,1.91971255119493,-4.28833299772577,0.596119471357712,"IGKC","immunoglobulin kappa constant",TRUE
+"214768_x_at",0.668587404382295,0.134873196155719,1.55181918095633,-4.83025458353927,0.880640393675685,"IGKC","immunoglobulin kappa constant",TRUE
+"216517_at",0.789795896476304,0.318379905452219,-1.02077095508022,-5.44453311222635,-0.828742352544854,"IGKC","immunoglobulin kappa constant",TRUE
+"214669_x_at",0.916443520723728,0.647036581365361,-0.464195131383965,-5.83527399745977,-0.296282366258632,"IGKC","immunoglobulin kappa constant",TRUE
+"216207_x_at",0.94960065125426,0.772044616738674,0.293270554702875,-5.89787894563341,0.16892319767172,"IGKC","immunoglobulin kappa constant",TRUE
+"214777_at",0.954449231029359,0.791068371492621,0.268144944137113,-5.90472336055325,0.124488364234218,"IGKC","immunoglobulin kappa constant",TRUE
+"217378_x_at",0.968064217766929,0.849435406444781,-0.192071814425614,-5.92173090889119,-0.072025903374739,"IGKV1OR2-108","immunoglobulin kappa variable 1/OR2-108 (non-functional)",TRUE
+"217480_x_at",0.955904644595647,0.800734065454702,0.255447254519198,-5.90795088627631,0.0807205608961183,"IGKV1OR2-118","immunoglobulin kappa variable 1/OR2-118 (pseudogene)",TRUE
+"217138_x_at",0.484495305292367,0.027860141560845,2.35375887657802,-3.55067039371312,1.18909595533208,"IGLC1","immunoglobulin lambda constant 1",TRUE
+"209138_x_at",0.54295328972902,0.0457239849354393,2.11694274908235,-3.96492336034099,1.28464489510575,"IGLC1","immunoglobulin lambda constant 1",TRUE
+"211655_at",0.627092759817312,0.0985774160924566,1.72431194408431,-4.58681363193036,1.62276355252668,"IGLC1","immunoglobulin lambda constant 1",TRUE
+"234350_at",0.794426378358553,0.326149148328401,1.00414626778452,-5.46015524512815,0.68894690589691,"IGLC1","immunoglobulin lambda constant 1",TRUE
+"214677_x_at",0.857148066512338,0.472010576370147,0.731716517956744,-5.68221684544684,0.232344430286465,"IGLC1","immunoglobulin lambda constant 1",TRUE
+"234851_at",0.861665593344139,0.483820876446428,0.712122179784898,-5.69565817009781,0.365260152619003,"IGLC1","immunoglobulin lambda constant 1",TRUE
+"215214_at",0.954456115752166,0.791390619006494,0.267720897243719,-5.90483365528991,0.209245268075631,"IGLC1","immunoglobulin lambda constant 1",TRUE
+"233969_at",0.983781970605789,0.920688653055483,-0.100707176195464,-5.9347449249618,-0.0525635574336789,"IGLC1","immunoglobulin lambda constant 1",TRUE
+"216560_x_at",0.99164669139131,0.96059024203595,0.0499748122840165,-5.93846712262372,0.0150167118367546,"IGLC1","immunoglobulin lambda constant 1",TRUE
+"216708_x_at",0.83949628091616,0.426040953206257,0.810912896372843,-5.62437762167811,0.502027136242054,"IGLJ3","immunoglobulin lambda joining 3",TRUE
+"216852_x_at",0.928176113526188,0.684349159781008,0.411929362535275,-5.85737203649437,0.149271606805295,"IGLJ3","immunoglobulin lambda joining 3",TRUE
+"211798_x_at",0.95952608973576,0.817177817317128,0.233942333811439,-5.91306209551538,0.126436575101923,"IGLJ3","immunoglobulin lambda joining 3",TRUE
+"216853_x_at",0.961395512423249,0.825090340390429,-0.223635131736762,-5.91535346768871,-0.100956231160775,"IGLJ3","immunoglobulin lambda joining 3",TRUE
+"211881_x_at",0.986342822130003,0.933195156123583,0.0847832226360473,-5.93618298243972,0.0329076299578679,"IGLJ3","immunoglobulin lambda joining 3",TRUE
+"216365_x_at",0.851319596585235,0.455033168688646,0.760397531585814,-5.66191843643603,0.465102435318792,"IGLJ3///CKAP2","immunoglobulin lambda joining 3///cytoskeleton associated protein 2",TRUE
+"234366_x_at",0.801086839730802,0.337389629095268,0.980573445817994,-5.48190718700738,0.304654197907999,"IGLJ3///CKAP2///IGLV@///IGLC1","immunoglobulin lambda joining 3///cytoskeleton associated protein 2///immunoglobulin lambda variable cluster///immunoglobulin lambda constant 1",TRUE
+"217148_x_at",0.876632890672003,0.525476941864348,0.645115099187966,-5.73898853226012,0.308411182941398,"IGLJ3///IGLV@///IGLC1","immunoglobulin lambda joining 3///immunoglobulin lambda variable cluster///immunoglobulin lambda constant 1",TRUE
+"216984_x_at",0.835952408568777,0.415931964770039,0.829025739909945,-5.61036495577777,0.524996243868418,"IGLJ3///IGLV1-44///CKAP2///IGLV@///IGLC1","immunoglobulin lambda joining 3///immunoglobulin lambda variable 1-44///cytoskeleton associated protein 2///immunoglobulin lambda variable cluster///immunoglobulin lambda constant 1",TRUE
+"234764_x_at",0.902681832009074,0.602019610461765,0.529067145638608,-5.80426061976942,0.511871475013359,"IGLJ3///IGLV1-44///CKAP2///IGLV@///IGLC1","immunoglobulin lambda joining 3///immunoglobulin lambda variable 1-44///cytoskeleton associated protein 2///immunoglobulin lambda variable cluster///immunoglobulin lambda constant 1",TRUE
+"206660_at",0.429276772897071,0.0188075054020975,2.53496199240584,-3.21703323656023,1.69871362040125,"IGLL1","immunoglobulin lambda like polypeptide 1",TRUE
+"215946_x_at",0.958933497686198,0.814237727992527,0.237778775658346,-5.91218300013614,0.0644562142877874,"IGLL3P","immunoglobulin lambda like polypeptide 3, pseudogene",TRUE
+"217235_x_at",0.875938621758472,0.524377897741247,-0.646844102579151,-5.73792200651242,-0.372066550986171,"IGLL5","immunoglobulin lambda like polypeptide 5",TRUE
+"216851_at",0.975398143273847,0.881929134063409,-0.150246987580834,-5.92869441856073,-0.0990898131332454,"IGLL5///IGLJ3///IGLV3-19","immunoglobulin lambda like polypeptide 5///immunoglobulin lambda joining 3///immunoglobulin lambda variable 3-19",TRUE
+"216566_at",0.784552021081681,0.308122531532459,1.04316092199731,-5.42312748855197,0.866641198073087,"IGLL5///IGLV@","immunoglobulin lambda like polypeptide 5///immunoglobulin lambda variable cluster",TRUE
+"234364_at",0.938726197187622,0.726941618654732,0.353653397046459,-5.87894906474145,0.218353618498598,"IGLL5///IGLV@","immunoglobulin lambda like polypeptide 5///immunoglobulin lambda variable cluster",TRUE
+"244694_at",0.991689960875868,0.960858255723474,0.0496346560758025,-5.93848362370328,0.0233117144523467,"IGLON5","IgLON family member 5",TRUE
+"217227_x_at",0.662575055303091,0.130338712306146,1.57106871360455,-4.80407350683657,1.00753275719994,"IGLV1-44","immunoglobulin lambda variable 1-44",TRUE
+"216430_x_at",0.677013732819214,0.144451972527914,1.5128493249237,-4.8824738387822,0.473422754143039,"IGLV1-44","immunoglobulin lambda variable 1-44",TRUE
+"216573_at",0.857148066512338,0.471957893258871,0.731804563864756,-5.68215566537828,0.567013465181649,"IGLV1-44","immunoglobulin lambda variable 1-44",TRUE
+"215379_x_at",0.899808883319249,0.59324595107935,0.54197364083023,-5.79761964426393,0.225615004101977,"IGLV1-44","immunoglobulin lambda variable 1-44",TRUE
+"234707_x_at",0.952914447461733,0.784423432351087,-0.276900379466935,-5.90240733669178,-0.124650351078741,"IGLV1-44","immunoglobulin lambda variable 1-44",TRUE
+"217258_x_at",0.990810941805126,0.953789512907955,0.0586082605817408,-5.93801059234181,0.0440826409683965,"IGLV1-44","immunoglobulin lambda variable 1-44",TRUE
+"215035_at",0.943325039520244,0.745446760997013,-0.328729766995932,-5.88718647777806,-0.171602419580503,"IGLV6-57","immunoglobulin lambda variable 6-57",TRUE
+"207695_s_at",0.877073609692444,0.526163957895055,0.644035297943065,-5.73965321040759,0.673748378423447,"IGSF1","immunoglobulin superfamily member 1",TRUE
+"223807_at",0.966313390701604,0.842958378421944,-0.200448448507805,-5.92013241533149,-0.13968980231336,"IGSF1","immunoglobulin superfamily member 1",TRUE
+"1556579_s_at",0.682539393883246,0.150212409594829,-1.49042335618825,-4.91204344113499,-0.876611446381979,"IGSF10","immunoglobulin superfamily member 10",TRUE
+"230670_at",0.955816406528307,0.798602440859858,0.258243779989159,-5.90725341392935,0.181418831832695,"IGSF10","immunoglobulin superfamily member 10",TRUE
+"228375_at",0.990810941805126,0.956517877033586,-0.0551441227226265,-5.93820249153743,-0.0560285854911946,"IGSF11","immunoglobulin superfamily member 11",TRUE
+"237253_at",0.955411502003638,0.795800552587978,0.26192284677824,-5.90632433754811,0.194514908820299,"IGSF11-AS1","IGSF11 antisense RNA 1",TRUE
+"227154_at",0.950887541143339,0.775626632901239,0.288525354531966,-5.89921813552234,0.326171070853758,"IGSF21","immunoglobin superfamily member 21",TRUE
+"1553857_at",0.951934441578502,0.779953384994755,-0.282802576777162,-5.90080438755432,-0.164102112472935,"IGSF22","immunoglobulin superfamily member 22",TRUE
+"1556162_at",0.712148529314333,0.186285290649357,1.36393314022694,-5.07206700085976,0.315725635401623,"IGSF3","immunoglobulin superfamily member 3",TRUE
+"1552672_a_at",0.927751423245943,0.682930252059981,0.413894796105641,-5.85658792990181,0.372866280661422,"IGSF3","immunoglobulin superfamily member 3",TRUE
+"1556163_a_at",0.942502815705589,0.74231474528478,0.332932781220966,-5.88583907691181,0.281334359963664,"IGSF3","immunoglobulin superfamily member 3",TRUE
+"202421_at",0.978316880841318,0.895738064041555,-0.132559747609156,-5.9311283877152,-0.109474735319441,"IGSF3","immunoglobulin superfamily member 3",TRUE
+"243027_at",0.565043084457947,0.0561432760898796,-2.01547447199112,-4.13393279606487,-1.95649465539067,"IGSF5","immunoglobulin superfamily member 5",TRUE
+"241068_at",0.932091525948902,0.700194085364461,-0.390091027759878,-5.86583715435298,-0.339212225539157,"IGSF6","immunoglobulin superfamily member 6",TRUE
+"206420_at",0.97763916244156,0.892205388172648,0.137080243602955,-5.93053522313692,0.0873024805801341,"IGSF6","immunoglobulin superfamily member 6",TRUE
+"225025_at",0.853460708803218,0.462149653391067,-0.748298875370279,-5.6705711730735,-0.482468528288811,"IGSF8","immunoglobulin superfamily member 8",TRUE
+"229276_at",0.986342822130003,0.935290911040097,0.0821171048197068,-5.93639964106979,0.0953813912820465,"IGSF9","immunoglobulin superfamily member 9",TRUE
+"215166_at",0.643515428391208,0.113967722730223,1.64556026988507,-4.70039562747814,0.567182558710856,"IGSF9B","immunoglobulin superfamily member 9B",TRUE
+"215255_at",0.905462783815257,0.611307393084468,-0.515502698410685,-5.8110721810705,-0.339476434679923,"IGSF9B","immunoglobulin superfamily member 9B",TRUE
+"229358_at",0.937863281185201,0.725179251545332,0.356038737510068,-5.87812951207642,0.224426499766452,"IHH","indian hedgehog",TRUE
+"215420_at",0.986342822130003,0.935324585017358,-0.0820742714489733,-5.9364030654091,-0.0621819361158913,"IHH","indian hedgehog",TRUE
+"200066_at",0.877861946695164,0.529187645557509,-0.639292007008208,-5.74256029802501,-0.184769050326492,"IK","IK cytokine, down-regulator of HLA II",TRUE
+"235202_x_at",0.899808883319249,0.592129893053035,0.543622069436747,-5.79676024619603,0.470372614977683,"IKBIP","IKBKB interacting protein",TRUE
+"227295_at",0.909748582642183,0.624656255785432,-0.496176565355724,-5.82047902482504,-0.321494176176502,"IKBIP","IKBKB interacting protein",TRUE
+"236249_at",0.989693960550456,0.950540635691368,-0.0627342437782261,-5.93776678401795,-0.0430223115003336,"IKBIP","IKBKB interacting protein",TRUE
+"202490_at",0.700633137129073,0.1724319980468,1.40997132251296,-5.01517197010639,0.628597145039061,"IKBKAP","inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein",TRUE
+"202491_s_at",0.95743098854986,0.807928652285418,-0.246023726331747,-5.91024560727393,-0.0761787939418053,"IKBKAP","inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein",TRUE
+"209342_s_at",0.581336273502073,0.0637463712148362,-1.95155008989055,-4.23756828461508,-0.961947095041735,"IKBKB","inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta",TRUE
+"209341_s_at",0.644844656970274,0.115123308140325,-1.64001768739793,-4.70823738825533,-0.890651837426962,"IKBKB","inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta",TRUE
+"211027_s_at",0.832605695407954,0.409352155479687,-0.840964677384022,-5.60097029196665,-0.404258015066935,"IKBKB","inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta",TRUE
+"214398_s_at",0.708473702007515,0.180538497220918,1.38268970857592,-5.04907619682255,0.606513490919978,"IKBKE","inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon",TRUE
+"204549_at",0.713633547141264,0.18869108469723,1.35621667236726,-5.08144945241103,0.713154524191889,"IKBKE","inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon",TRUE
+"209929_s_at",0.666643938027574,0.133395165007681,-1.55803402422811,-4.82182962077969,-0.601498161720679,"IKBKG","inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma",TRUE
+"36004_at",0.813065886130395,0.36258508194499,-0.929621934992478,-5.52730894970233,-0.287569451659941,"IKBKG","inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma",TRUE
+"1565816_at",0.557512088623721,0.0523461841146641,2.05033564710927,-4.07647804348648,0.678930075189378,"IKZF1","IKAROS family zinc finger 1",TRUE
+"227344_at",0.559434208511607,0.054011139082992,2.03478106153255,-4.1021939612007,1.1593107180093,"IKZF1","IKAROS family zinc finger 1",TRUE
+"1565818_s_at",0.655745626967443,0.124241405747134,1.59784815487903,-4.767230963334,1.34191719490829,"IKZF1","IKAROS family zinc finger 1",TRUE
+"216901_s_at",0.771159692311272,0.280311779251138,-1.1066600438993,-5.36015893264955,-0.71457127862348,"IKZF1","IKAROS family zinc finger 1",TRUE
+"227346_at",0.82881747286857,0.399393762371618,-0.859268663589123,-5.58632368426187,-0.724392016316909,"IKZF1","IKAROS family zinc finger 1",TRUE
+"205038_at",0.841420204214686,0.432095773136479,0.800192403313631,-5.63253448989928,0.617076291278969,"IKZF1","IKAROS family zinc finger 1",TRUE
+"1565817_at",0.868220463162593,0.502240117530334,0.68210738571939,-5.71557321372869,0.493919473386508,"IKZF1","IKAROS family zinc finger 1",TRUE
+"220704_at",0.974884920935236,0.876835010138115,-0.156783926624457,-5.92771797195186,-0.134797820070106,"IKZF1","IKAROS family zinc finger 1",TRUE
+"205039_s_at",0.999643028557982,0.999240794508996,-0.000962316475045756,-5.93968302970284,-0.000715868957682275,"IKZF1","IKAROS family zinc finger 1",TRUE
+"220567_at",0.552420073963858,0.049857911307197,2.074426609152,-4.03639655145846,1.61973654290792,"IKZF2","IKAROS family zinc finger 2",TRUE
+"1555060_a_at",0.580630437263151,0.0633728245243988,1.95452882304818,-4.23278943354077,1.03613243634422,"IKZF2","IKAROS family zinc finger 2",TRUE
+"231929_at",0.595453032706696,0.0721820883957749,1.88806672649053,-4.33821761099866,1.2690917439232,"IKZF2","IKAROS family zinc finger 2",TRUE
+"236301_at",0.85042566396989,0.453027280010966,0.763828227344628,-5.65944097988285,0.715299832365602,"IKZF3","IKAROS family zinc finger 3",TRUE
+"221092_at",0.877948371309952,0.529675445377779,0.638528173792116,-5.74302650832684,0.58682906603346,"IKZF3","IKAROS family zinc finger 3",TRUE
+"227030_at",0.93919895813272,0.727928260216128,-0.352318904231206,-5.87940519389778,-0.369866538819433,"IKZF3","IKAROS family zinc finger 3",TRUE
+"226761_at",0.677509122383198,0.144951290674157,1.51087677261926,-4.88508891224488,0.435907276316009,"IKZF4","IKAROS family zinc finger 4",TRUE
+"208472_at",0.816800680706682,0.368291562344299,-0.91841576605127,-5.53699609991792,-0.271026161163538,"IKZF4","IKAROS family zinc finger 4",TRUE
+"229752_at",0.976660494182006,0.88885299747391,0.141372747647444,-5.92995359933769,0.0588164749739537,"IKZF4","IKAROS family zinc finger 4",TRUE
+"226759_at",0.994174089523038,0.97349963246245,-0.0335966355020024,-5.93913373102805,-0.0129952302500849,"IKZF4","IKAROS family zinc finger 4",TRUE
+"220086_at",0.835359769097686,0.414607848398517,0.831418663702158,-5.6084920450138,0.289564147262606,"IKZF5","IKAROS family zinc finger 5",TRUE
+"226680_at",0.963120895816356,0.832447691146812,-0.214073323609639,-5.91738726723104,-0.0979489736499985,"IKZF5","IKAROS family zinc finger 5",TRUE
+"207433_at",0.842348838616739,0.436078447722787,-0.793191457138138,-5.63780620030929,-0.613312932537843,"IL10","interleukin 10",TRUE
+"204912_at",0.886837210100958,0.550414885917986,0.606396053015126,-5.76215222794329,0.18512653099424,"IL10RA","interleukin 10 receptor subunit alpha",TRUE
+"209575_at",0.642592458809121,0.112914558218782,1.65065293981676,-4.69317255921142,0.509762087226864,"IL10RB","interleukin 10 receptor subunit beta",TRUE
+"230631_s_at",0.369623435296638,0.0110592589648061,2.77260905044373,-2.76087662102217,1.45429804110199,"IL10RB-AS1","IL10RB antisense RNA 1 (head to head)",TRUE
+"230632_at",0.870980161749509,0.5110976606472,0.667896262367303,-5.72471647502405,0.323556457408062,"IL10RB-AS1","IL10RB antisense RNA 1 (head to head)",TRUE
+"206924_at",0.384135218769668,0.0123444826786597,2.72399211799435,-2.85574517513668,2.90677659363501,"IL11","interleukin 11",TRUE
+"206926_s_at",0.624331975868069,0.0957116191961381,1.74011857272019,-4.56353702292865,1.15711240875825,"IL11","interleukin 11",TRUE
+"204773_at",0.855347208215553,0.467824470315096,0.738730650478822,-5.6773210757723,0.733994269699858,"IL11RA","interleukin 11 receptor subunit alpha",TRUE
+"1552646_at",0.992129073515375,0.963436953709995,-0.0463621382636706,-5.93863661817079,-0.014135994331876,"IL11RA","interleukin 11 receptor subunit alpha",TRUE
+"207160_at",0.73759219552868,0.224261933637195,1.25022252374927,-5.20576734483522,0.849574446868925,"IL12A","interleukin 12A",TRUE
+"1560725_at",0.707506589324893,0.178924437322273,1.3880427833529,-5.04246687744046,0.891925586438662,"IL12A-AS1","IL12A antisense RNA 1",TRUE
+"207901_at",0.702888118552354,0.174825341091787,-1.40181227426405,-5.02536896000005,-0.690868609119097,"IL12B","interleukin 12B",TRUE
+"1552584_at",0.496742810480539,0.0303404205159712,2.31371504799182,-3.62254139002185,1.72388477034123,"IL12RB1","interleukin 12 receptor subunit beta 1",TRUE
+"206890_at",0.64764572871099,0.118809083840352,1.62264621302362,-4.732683120255,0.877326422544859,"IL12RB1","interleukin 12 receptor subunit beta 1",TRUE
+"239522_at",0.992342196993659,0.964114081622366,-0.0455029110340596,-5.93867505959192,-0.0259774500266561,"IL12RB1","interleukin 12 receptor subunit beta 1",TRUE
+"206999_at",0.864079461576774,0.49112433600794,0.700143875562811,-5.70370394275594,0.459917223264378,"IL12RB2","interleukin 12 receptor subunit beta 2",TRUE
+"207844_at",0.962905928655899,0.831776109698516,-0.2149452688512,-5.91720546955858,-0.10722901859279,"IL13","interleukin 13",TRUE
+"201887_at",0.705100208997726,0.176920048794994,-1.39474409003523,-5.03416312759646,-0.74254308125573,"IL13RA1","interleukin 13 receptor subunit alpha 1",TRUE
+"210904_s_at",0.771527793162888,0.280774687093167,-1.10556677929055,-5.36127110264162,-0.542374943903187,"IL13RA1","interleukin 13 receptor subunit alpha 1",TRUE
+"211612_s_at",0.830635993561085,0.403950937993606,-0.850856564354877,-5.59309144761099,-0.401371226150827,"IL13RA1","interleukin 13 receptor subunit alpha 1",TRUE
+"201888_s_at",0.982093200363011,0.913978014511337,-0.109262264015234,-5.93387047537936,-0.0629270383885228,"IL13RA1","interleukin 13 receptor subunit alpha 1",TRUE
+"206172_at",0.419258213999957,0.0172784243010298,2.57342344195764,-3.14455531821379,1.62793889293583,"IL13RA2","interleukin 13 receptor subunit alpha 2",TRUE
+"205992_s_at",0.274882222151803,0.00439712700796174,3.17105097375149,-1.95858897351894,2.30654664245806,"IL15","interleukin 15",TRUE
+"217371_s_at",0.53333138995891,0.0421925469877968,2.15609718647573,-3.89828759402881,1.88176345791935,"IL15","interleukin 15",TRUE
+"207375_s_at",0.513155786517087,0.0344450249020157,2.25361198810071,-3.72906462286954,1.94296681558321,"IL15RA","interleukin 15 receptor subunit alpha",TRUE
+"1555016_at",0.649614899559272,0.1201564788156,1.61640844861609,-4.74141213196891,0.441145622028454,"IL16","interleukin 16",TRUE
+"209828_s_at",0.767965891104819,0.27110300289075,1.12868705531616,-5.33754358953213,0.776791562044804,"IL16","interleukin 16",TRUE
+"209827_s_at",0.899755026004388,0.59143790507612,-0.544644907852056,-5.79622572049796,-0.172576601132706,"IL16","interleukin 16",TRUE
+"208402_at",0.796378050779806,0.328856241459605,0.998418383184458,-5.46548384660528,0.72436462355148,"IL17A","interleukin 17A",TRUE
+"216876_s_at",0.89961817630669,0.590622598274243,0.545850780424168,-5.7955942887996,0.495955749006778,"IL17A","interleukin 17A",TRUE
+"220273_at",0.830635993561085,0.404377210724315,-0.85007282297057,-5.59371882882676,-0.502117961081332,"IL17B","interleukin 17B",TRUE
+"224079_at",0.995111934465262,0.977466874265407,-0.0285654898051181,-5.93928605128054,-0.0134159762391803,"IL17C","interleukin 17C",TRUE
+"227401_at",0.978197434639598,0.894313082805396,0.134382841655471,-5.93089155624282,0.0620085807385076,"IL17D","interleukin 17D",TRUE
+"234408_at",0.981938272709769,0.913350759888944,-0.110062339355351,-5.93378505690264,-0.0805093411137423,"IL17F","interleukin 17F",TRUE
+"229295_at",0.45007709514462,0.0215098573317401,-2.47362314658371,-3.33145513091234,-1.01429986621012,"IL17RA","interleukin 17 receptor A",TRUE
+"229101_at",0.946257232656659,0.756555805548298,-0.313869962034139,-5.89181435183352,-0.104167480329799,"IL17RA","interleukin 17 receptor A",TRUE
+"228685_at",0.977128286470696,0.890862200713146,0.138799780803837,-5.93030437895219,0.0493888700364806,"IL17RA","interleukin 17 receptor A",TRUE
+"205707_at",0.986889306520757,0.93900109297916,0.0773986737455246,-5.93676612358685,0.0250820328798422,"IL17RA","interleukin 17 receptor A",TRUE
+"219255_x_at",0.77340139236553,0.284736819485877,-1.09626232461105,-5.37069691467778,-0.888344267851151,"IL17RB","interleukin 17 receptor B",TRUE
+"224156_x_at",0.774011928861764,0.285824549645322,-1.09372436359349,-5.37325567728631,-0.7065982660837,"IL17RB","interleukin 17 receptor B",TRUE
+"224361_s_at",0.830000544166181,0.401739998185895,-0.85493009784635,-5.58982192486648,-0.699565008234149,"IL17RB","interleukin 17 receptor B",TRUE
+"224514_x_at",0.55937703282623,0.0535439861572968,-2.03910169476198,-4.09506372210236,-1.00191480188555,"IL17RC","interleukin 17 receptor C",TRUE
+"64440_at",0.741816732763138,0.232313757287367,-1.22805216765198,-5.23067688818018,-0.479373375668382,"IL17RC","interleukin 17 receptor C",TRUE
+"221926_s_at",0.813442508625161,0.363898367417245,-0.927032580467096,-5.52955691720874,-0.964157605922302,"IL17RC","interleukin 17 receptor C",TRUE
+"221947_at",0.988920414897503,0.946433463738944,-0.0679518442009592,-5.9374347398018,-0.0356490257574738,"IL17RC","interleukin 17 receptor C",TRUE
+"227997_at",0.768852835478002,0.272899996687945,1.12434630478302,-5.34203148604624,0.610445738538965,"IL17RD","interleukin 17 receptor D",TRUE
+"229263_at",0.877746514710382,0.528574375799531,0.64025285385569,-5.74197307837552,0.449267682635091,"IL17RD","interleukin 17 receptor D",TRUE
+"236186_x_at",0.728385463227073,0.209711581032281,1.29188163166363,-5.15792976029374,1.04954306670868,"IL17RE","interleukin 17 receptor E",TRUE
+"229401_at",0.895690630367785,0.576338217960111,0.567113472832467,-5.78423784371923,0.393525761285748,"IL17RE","interleukin 17 receptor E",TRUE
+"206295_at",0.375627940417863,0.0114457457473463,2.75744931676305,-2.79053867675761,3.28098217085847,"IL18","interleukin 18",TRUE
+"219323_s_at",0.328663980090165,0.00779472761533724,2.9255530887096,-2.45779944316868,1.55132744907279,"IL18BP","interleukin 18 binding protein",TRUE
+"222868_s_at",0.68664628884457,0.155112360558195,1.47189258138252,-4.93620883954823,0.580478113488001,"IL18BP","interleukin 18 binding protein",TRUE
+"224283_x_at",0.70939075283402,0.182364005847538,1.37668093783604,-5.05646984379125,0.497641115039483,"IL18BP","interleukin 18 binding protein",TRUE
+"206618_at",0.774230543658252,0.289714179913032,1.08470546169262,-5.38230574777954,0.850736634112599,"IL18R1","interleukin 18 receptor 1",TRUE
+"207072_at",0.994098505325585,0.972644864035701,-0.0346807408675575,-5.939097680704,-0.0208727289306783,"IL18RAP","interleukin 18 receptor accessory protein",TRUE
+"220745_at",0.610460404244826,0.083158831107736,-1.81453926947043,-4.45185422842417,-1.26291299617359,"IL19","interleukin 19",TRUE
+"210118_s_at",0.0014539429975398,2.12739716146656e-07,7.37362657070368,6.62644158739593,4.93390122956011,"IL1A","interleukin 1 alpha",TRUE
+"208200_at",0.609539262323192,0.0818404705023237,1.82290804735638,-4.43908301843544,0.913457191274279,"IL1A","interleukin 1 alpha",TRUE
+"39402_at",0.000171298494330477,1.5665157231868e-08,8.62392049678007,8.7217059982953,3.23865342244937,"IL1B","interleukin 1 beta",TRUE
+"205067_at",0.0550194051692779,9.74211181768539e-05,4.73978229066315,1.39491492184984,1.73010337930427,"IL1B","interleukin 1 beta",TRUE
+"224262_at",0.931528703027792,0.697381488291424,-0.39395312747465,-5.86437314895476,-0.240828221966856,"IL1F10","interleukin 1 family member 10 (theta)",TRUE
+"202948_at",0.687277721925286,0.155900932064322,-1.46895490874668,-4.9400173369382,-1.70979078906325,"IL1R1","interleukin 1 receptor type 1",TRUE
+"215561_s_at",0.83766047465051,0.422206145914408,-0.817751880151329,-5.6191208547862,-0.891194711622305,"IL1R1","interleukin 1 receptor type 1",TRUE
+"211372_s_at",0.0897427148869195,0.00034780412398912,4.22026400608242,0.274980253669235,3.80217725891661,"IL1R2","interleukin 1 receptor type 2",TRUE
+"205403_at",0.199181589554674,0.0022032588371258,3.46143859126405,-1.35236115650782,3.78658107775973,"IL1R2","interleukin 1 receptor type 2",TRUE
+"205227_at",0.414637020271776,0.0167674888307434,2.58698821939735,-3.11886289631079,1.80160786125284,"IL1RAP","interleukin 1 receptor accessory protein",TRUE
+"210233_at",0.62524538993269,0.0964602508443254,1.73595079373775,-4.56968974779396,1.3988437527567,"IL1RAP","interleukin 1 receptor accessory protein",TRUE
+"222963_s_at",0.784448016670989,0.307444339463057,1.04465970101444,-5.4216796643647,0.893683023596956,"IL1RAPL1","interleukin 1 receptor accessory protein like 1",TRUE
+"220663_at",0.841550580403629,0.433312946117498,0.798048580196203,-5.63415341527416,0.509446603474953,"IL1RAPL1","interleukin 1 receptor accessory protein like 1",TRUE
+"221112_at",0.727286289873957,0.207624115861648,-1.29803959496922,-5.1507452608378,-0.434781065441738,"IL1RAPL2","interleukin 1 receptor accessory protein like 2",TRUE
+"234066_at",0.396457278736589,0.0136901937312241,2.6779716994479,-2.94484250528588,0.94292859894118,"IL1RL1","interleukin 1 receptor like 1",TRUE
+"242809_at",0.861659105448003,0.482806744962175,0.713793689880407,-5.69452508897214,0.33512314803765,"IL1RL1","interleukin 1 receptor like 1",TRUE
+"207526_s_at",0.932918358096654,0.703981869913578,-0.384899370373813,-5.86778275790865,-0.24382975407736,"IL1RL1","interleukin 1 receptor like 1",TRUE
+"210442_at",0.978314802155638,0.895612085821603,-0.132720903130183,-5.93110758270759,-0.0441900154751957,"IL1RL1","interleukin 1 receptor like 1",TRUE
+"208038_at",0.724067243569133,0.201109015751396,1.31757323489081,-5.12776394569531,1.10561251395813,"IL1RL2","interleukin 1 receptor like 2",TRUE
+"216244_at",0.0681210092794308,0.000174564583045214,4.50147077040909,0.88227090018435,2.7522107801484,"IL1RN","interleukin 1 receptor antagonist",TRUE
+"216243_s_at",0.183534093706442,0.00177240057571105,3.55188249490781,-1.16090309207118,2.02500548044038,"IL1RN","interleukin 1 receptor antagonist",TRUE
+"212657_s_at",0.29255198477894,0.00516346895860407,3.10268108048992,-2.09901824995957,2.67243931615484,"IL1RN","interleukin 1 receptor antagonist",TRUE
+"212659_s_at",0.480603497646452,0.0271440987788248,2.36593011132172,-3.52868650079742,1.24168612436661,"IL1RN","interleukin 1 receptor antagonist",TRUE
+"216245_at",0.778031107955451,0.297409239255033,1.06711620358083,-5.39976324259531,0.768470014360128,"IL1RN","interleukin 1 receptor antagonist",TRUE
+"217181_at",0.774230543658252,0.286379168044247,1.09243297775583,-5.37455562084855,0.404758250966481,"IL2","interleukin 2",TRUE
+"207849_at",0.819193107051406,0.375776373139078,0.903891047416786,-5.54939074395048,0.80425721487691,"IL2","interleukin 2",TRUE
+"224071_at",0.788039658538346,0.314187147907203,-1.02986076543306,-5.43589343266036,-1.10049819890993,"IL20","interleukin 20",TRUE
+"222829_s_at",0.298372619814585,0.0054977342703989,3.0758827924384,-2.15378198801979,3.3900145561309,"IL20RA","interleukin 20 receptor subunit alpha",TRUE
+"219115_s_at",0.500677386446044,0.0319755954981606,2.28892857778494,-3.66667083575309,2.92940141226453,"IL20RA","interleukin 20 receptor subunit alpha",TRUE
+"222828_at",0.958535988044534,0.812060118266536,-0.240622629187647,-5.91152217183234,-0.132478047146061,"IL20RA","interleukin 20 receptor subunit alpha",TRUE
+"228575_at",0.594972224548427,0.0716261268362153,1.89204455567936,-4.33197901405606,1.6335515092956,"IL20RB","interleukin 20 receptor subunit beta",TRUE
+"221271_at",0.655548963436249,0.124064891218976,1.59863956006038,-4.76613478213558,1.0493588669203,"IL21","interleukin 21",TRUE
+"221658_s_at",0.878278790222455,0.530989903434842,0.63647179758304,-5.7442789668329,0.424713566678403,"IL21R","interleukin 21 receptor",TRUE
+"237753_at",0.937203701144735,0.721155385162264,0.361492913179919,-5.87623512674592,0.137215378569968,"IL21R","interleukin 21 receptor",TRUE
+"219971_at",0.955752634534966,0.798201491979353,-0.258770028236198,-5.90712132050466,-0.168326309614121,"IL21R","interleukin 21 receptor",TRUE
+"1559443_s_at",0.7717895132349,0.281404012740805,1.10408257619217,-5.36277940924011,0.752526046271774,"IL21R-AS1","IL21R antisense RNA 1",TRUE
+"221165_s_at",0.767727587789514,0.270197633481181,1.13088201528173,-5.33526840712408,0.295378804422685,"IL22","interleukin 22",TRUE
+"222974_at",0.968066640321622,0.850229864531272,-0.191045334628278,-5.92192211410508,-0.161416776602469,"IL22","interleukin 22",TRUE
+"220056_at",0.289816987027404,0.00499610611998426,3.11673393225864,-2.07023640228568,1.30822420812574,"IL22RA1","interleukin 22 receptor subunit alpha 1",TRUE
+"237493_at",0.996771621728225,0.983685015414681,0.0206812856681642,-5.93947515840855,0.0207604738634894,"IL22RA2","interleukin 22 receptor subunit alpha 2",TRUE
+"220054_at",0.478834284119248,0.0268427449625148,2.37114118739723,-3.51925464285363,1.60401039486882,"IL23A","interleukin 23 subunit alpha",TRUE
+"234377_at",0.816800680706682,0.368843548974832,0.917337950458478,-5.53792211084584,0.640591308233103,"IL23A","interleukin 23 subunit alpha",TRUE
+"234865_at",0.833105361660875,0.410276326162543,0.839280478467862,-5.60230318011163,0.589241452231822,"IL23A","interleukin 23 subunit alpha",TRUE
+"216857_at",0.986421906591669,0.936371893690665,0.0807421707098979,-5.93650866977399,0.0664668144063505,"IL23A","interleukin 23 subunit alpha",TRUE
+"217326_x_at",0.852006864319744,0.45721434854949,0.756677348315578,-5.66459302494812,0.403872177860057,"IL23A///TRBV19","interleukin 23 subunit alpha///T cell receptor beta variable 19",TRUE
+"1561853_a_at",0.831971841409434,0.408288926549064,-0.842905288197872,-5.59943138379475,-0.498984055621639,"IL23R","interleukin 23 receptor",TRUE
+"1552912_a_at",0.974451535839172,0.875117095395355,-0.158989972016481,-5.92737908537618,-0.133757471709252,"IL23R","interleukin 23 receptor",TRUE
+"206569_at",0.723655063748891,0.200496464292354,1.31943500386453,-5.12555843568229,1.17392447708555,"IL24","interleukin 24",TRUE
+"220971_at",0.975624333648212,0.883763079517055,-0.14789526669096,-5.9290355561572,-0.0879534958298418,"IL25","interleukin 25",TRUE
+"221111_at",0.94895689004559,0.768752349894594,-0.297637984536448,-5.89662722485662,-0.315596432910757,"IL26","interleukin 26",TRUE
+"1552995_at",0.997171203405,0.985565626658961,-0.018297079282449,-5.93952042155493,-0.0113946619001526,"IL27","interleukin 27",TRUE
+"222062_at",0.580630437263151,0.0632560908521958,1.95546285836908,-4.23128991393068,2.55123673929676,"IL27RA","interleukin 27 receptor subunit alpha",TRUE
+"205926_at",0.677013732819214,0.144447153344058,1.51286839025595,-4.88244854998218,1.25264874022462,"IL27RA","interleukin 27 receptor subunit alpha",TRUE
+"217702_at",0.977160030692682,0.89105593244427,-0.138551740758747,-5.93033785508019,-0.0781577296769376,"IL27RA","interleukin 27 receptor subunit alpha",TRUE
+"211269_s_at",0.770075820151416,0.27875335982648,-1.11035027952622,-5.35639767936862,-0.506922364035889,"IL2RA","interleukin 2 receptor subunit alpha",TRUE
+"206341_at",0.924696623416105,0.674223775745258,0.425991510765758,-5.85168117150743,0.26076403216084,"IL2RA","interleukin 2 receptor subunit alpha",TRUE
+"205291_at",0.806735395676905,0.347979984021328,0.958852774939732,-5.50153300902991,0.439124165674844,"IL2RB","interleukin 2 receptor subunit beta",TRUE
+"204116_at",0.671298718565642,0.137211358404186,1.54210153429834,-4.84337469581539,0.99495718462367,"IL2RG","interleukin 2 receptor subunit gamma",TRUE
+"207906_at",0.631042425838988,0.102163818297192,1.70507383828698,-4.61492942867973,0.893848573838771,"IL3","interleukin 3",TRUE
+"1553032_at",0.926735112907652,0.680818021318947,-0.41682367973982,-5.85541264544457,-0.2196011832423,"IL31RA","interleukin 31 receptor A",TRUE
+"243541_at",0.945498722604777,0.753808622978063,0.317537842506477,-5.89069174320607,0.257681219673935,"IL31RA","interleukin 31 receptor A",TRUE
+"1555431_a_at",0.948668195792872,0.766576280282053,-0.300527940201739,-5.89578886751354,-0.288258141025597,"IL31RA","interleukin 31 receptor A",TRUE
+"203828_s_at",0.322131160460075,0.00727251454217602,2.95558340568984,-2.39752364321811,4.31078443475587,"IL32","interleukin 32",TRUE
+"209821_at",0.896115372949367,0.577280620653503,0.56570261940814,-5.78500442161303,0.449225576952857,"IL33","interleukin 33",TRUE
+"237046_x_at",0.971094654049796,0.861445070940972,-0.176576568267149,-5.92450860119023,-0.0929679932497134,"IL34","interleukin 34",TRUE
+"221404_at",0.834265235157814,0.412207742323707,-0.835768447453522,-5.60507459828122,-0.368965930318475,"IL36A","interleukin 36, alpha",TRUE
+"231755_at",0.183534093706442,0.00174741641539142,3.55776952494967,-1.14840546921862,1.58064277582386,"IL36B","interleukin 36, beta",TRUE
+"224230_at",0.936599157163462,0.716892990912045,0.367282618967301,-5.87419308900791,0.248304356363251,"IL36B","interleukin 36, beta",TRUE
+"220322_at",0.634202341398092,0.105252349918456,1.68896136119093,-4.63829493506454,0.905827378040684,"IL36G","interleukin 36, gamma",TRUE
+"222223_s_at",0.760273470806608,0.25865289127524,1.15935673830386,-5.30540026311763,0.474940972879456,"IL36RN","interleukin 36 receptor antagonist",TRUE
+"221470_s_at",0.470295441559609,0.0252445753464771,2.39971352974398,-3.46733397940104,1.34375899334864,"IL37","interleukin 37",TRUE
+"224555_x_at",0.767011398042819,0.268534998337306,1.13492695729831,-5.33106540745203,0.536755571437131,"IL37","interleukin 37",TRUE
+"206148_at",0.666643938027574,0.13356045170835,1.55733620640925,-4.82277691902967,0.557545098800953,"IL3RA","interleukin 3 receptor subunit alpha",TRUE
+"207538_at",0.846836685339183,0.445354134236644,0.77703719413169,-5.64980386842801,0.757739143862367,"IL4","interleukin 4",TRUE
+"207539_s_at",0.93523910610914,0.711914617929274,0.374061101217573,-5.87176161653375,0.282271145209493,"IL4","interleukin 4",TRUE
+"230966_at",0.208428274543958,0.00239783053842066,3.42615121101232,-1.42676131878701,1.81493861941047,"IL4I1","interleukin 4 induced 1",TRUE
+"214935_at",0.737488397392592,0.223680831394827,-1.25184590354161,-5.20392833863841,-0.658875771922844,"IL4I1///NUP62","interleukin 4 induced 1///nucleoporin 62",TRUE
+"203233_at",0.582758622011397,0.0644205415900664,1.94621289201856,-4.24611840610514,1.94824282252597,"IL4R","interleukin 4 receptor",TRUE
+"207952_at",0.580630437263151,0.0631355501737811,1.95642895357518,-4.229738410368,1.41771089239757,"IL5","interleukin 5",TRUE
+"211516_at",0.736132227107113,0.221529393617129,1.25788442359331,-5.19706978004223,0.465533674310291,"IL5RA","interleukin 5 receptor subunit alpha",TRUE
+"210744_s_at",0.758966211371161,0.256445220775048,1.16490834744735,-5.29950099388869,0.450934999836423,"IL5RA","interleukin 5 receptor subunit alpha",TRUE
+"211517_s_at",0.885627706141628,0.547235578800952,-0.61127943885978,-5.75930685789437,-0.275340955693673,"IL5RA","interleukin 5 receptor subunit alpha",TRUE
+"207902_at",0.970540753946729,0.859702617609817,0.178821902446515,-5.92412052122322,0.120665840692044,"IL5RA","interleukin 5 receptor subunit alpha",TRUE
+"205207_at",0.21219412234776,0.00248539899718823,3.41117418677305,-1.45828450284941,3.36870126400308,"IL6","interleukin 6",TRUE
+"226333_at",0.891390319214715,0.560838939488515,-0.59048769019998,-5.77126858170617,-0.515939043195919,"IL6R","interleukin 6 receptor",TRUE
+"205945_at",0.947969282616012,0.763283754705624,-0.304905600021783,-5.89450364254774,-0.20627115278528,"IL6R","interleukin 6 receptor",TRUE
+"217489_s_at",0.998965910333026,0.996620346921559,-0.00428382795887541,-5.93967454256892,-0.00289913985845391,"IL6R","interleukin 6 receptor",TRUE
+"234474_x_at",0.744307803443383,0.235236165406061,1.22014980431561,-5.23946262875506,0.863570516283923,"IL6ST","interleukin 6 signal transducer",TRUE
+"204863_s_at",0.873301865850313,0.518122337051315,0.65672338646171,-5.73177547227625,0.666354103207707,"IL6ST","interleukin 6 signal transducer",TRUE
+"211000_s_at",0.895370220688938,0.573810920592032,0.570902801326885,-5.78216977632693,0.436296904300674,"IL6ST","interleukin 6 signal transducer",TRUE
+"212195_at",0.896118635245982,0.577833381179597,0.564875631616452,-5.7854528993281,0.487828202349821,"IL6ST","interleukin 6 signal transducer",TRUE
+"212196_at",0.902810270244072,0.60246795647234,0.528410060846488,-5.80459455336166,0.379876214083833,"IL6ST","interleukin 6 signal transducer",TRUE
+"234967_at",0.92051722798026,0.662012740380549,-0.443067468878152,-5.84451839444823,-0.228441522496609,"IL6ST","interleukin 6 signal transducer",TRUE
+"204864_s_at",0.930527241884777,0.692643466672839,0.400472964142795,-5.86186944167702,0.299295831265264,"IL6ST","interleukin 6 signal transducer",TRUE
+"206693_at",0.519956259865057,0.0375453153903499,2.21240828239984,-3.80112455500775,1.87914088791787,"IL7","interleukin 7",TRUE
+"226218_at",0.13642152284541,0.000880782762952534,3.84026654364686,-0.544621840624274,3.96316158075775,"IL7R","interleukin 7 receptor",TRUE
+"205798_at",0.321503515621139,0.00714452256935864,2.96325859601573,-2.38208034487216,2.02178963123542,"IL7R","interleukin 7 receptor",TRUE
+"208193_at",0.877861946695164,0.529380273802704,0.638990329675904,-5.74274449265963,0.461386670817411,"IL9","interleukin 9",TRUE
+"214950_at",0.617775129514679,0.0886277677442457,-1.7810035776868,-4.50260412240928,-0.622228984491758,"IL9R","interleukin 9 receptor",TRUE
+"217212_s_at",0.882059205223864,0.539490341030758,0.623239376182989,-5.75224531804713,0.19062514444754,"IL9R","interleukin 9 receptor",TRUE
+"208164_s_at",0.990810941805126,0.954122708068741,0.0581851722274897,-5.93803465609535,0.0439206873544151,"IL9R","interleukin 9 receptor",TRUE
+"1553545_at",0.789927874973432,0.319022231454686,-1.01938582948907,-5.44584356976246,-0.65212124678029,"ILDR1","immunoglobulin like domain containing receptor 1",TRUE
+"235583_at",0.896907177224677,0.582058719017576,0.558567157096959,-5.78885305896242,0.554014176844813,"ILDR1","immunoglobulin like domain containing receptor 1",TRUE
+"229380_at",0.70510836231135,0.176950925272502,-1.39464040311302,-5.03429186050148,-1.06766340124461,"ILDR2","immunoglobulin like domain containing receptor 2",TRUE
+"240153_at",0.841420204214686,0.432256591667636,0.799908937406423,-5.63274878569267,0.700880399030383,"ILDR2","immunoglobulin like domain containing receptor 2",TRUE
+"200052_s_at",0.841641983271935,0.433506776411175,-0.79770752822133,-5.63441058696752,-0.243099077392078,"ILF2","interleukin enhancer binding factor 2",TRUE
+"211375_s_at",0.631042425838988,0.102167124893036,1.70505636818942,-4.61495485321761,0.530003351977681,"ILF3","interleukin enhancer binding factor 3",TRUE
+"217805_at",0.654623800601032,0.123581113757027,1.6008134055793,-4.76312160109751,0.552312074529347,"ILF3","interleukin enhancer binding factor 3",TRUE
+"208930_s_at",0.771623843789204,0.281087006799261,1.10482990242053,-5.36202017134224,0.514182442366872,"ILF3","interleukin enhancer binding factor 3",TRUE
+"208931_s_at",0.812302873476553,0.359129028524247,0.936466257192987,-5.52133924904234,0.563526816587023,"ILF3","interleukin enhancer binding factor 3",TRUE
+"217804_s_at",0.946257232656659,0.756544956912203,0.313884437839273,-5.89180994669275,0.0839521820584892,"ILF3","interleukin enhancer binding factor 3",TRUE
+"235014_at",0.877546037473893,0.527929157171831,-0.64126441215187,-5.74135395060075,-0.362711471109387,"ILF3-AS1","ILF3 antisense RNA 1 (head to head)",TRUE
+"201234_at",0.886023097762234,0.548238470028012,0.609737394564435,-5.76020772925107,0.226707777720387,"ILK","integrin linked kinase",TRUE
+"221548_s_at",0.89203601623083,0.562363858666058,-0.588173413233227,-5.77257527133998,-0.182807823906321,"ILKAP","ILK associated serine/threonine phosphatase",TRUE
+"216270_at",0.67397614409571,0.140538636264907,1.52850560893079,-4.86162136019898,0.46500456763219,"ILVBL","ilvB acetolactate synthase like",TRUE
+"202993_at",0.803566977998733,0.341765067653379,0.97154377822741,-5.49011471516669,0.392402493685289,"ILVBL","ilvB acetolactate synthase like",TRUE
+"210624_s_at",0.815195559141692,0.36614835798334,0.922610834742773,-5.53338234792113,0.300259118074182,"ILVBL","ilvB acetolactate synthase like",TRUE
+"229025_s_at",0.630603891142543,0.101671676803326,-1.70767940094591,-4.61113532028398,-0.564609355464878,"IMMP1L","inner mitochondrial membrane peptidase subunit 1",TRUE
+"230556_at",0.947926063538122,0.762804072458243,0.305543879339518,-5.8943147131796,0.116268905916893,"IMMP1L","inner mitochondrial membrane peptidase subunit 1",TRUE
+"227153_at",0.904381089098038,0.607649879470414,-0.52083253033187,-5.80841628970755,-0.214652221684133,"IMMP2L","inner mitochondrial membrane peptidase subunit 2",TRUE
+"1555571_at",0.951006866397403,0.776273582196973,0.287669046075778,-5.89945749474448,0.261745499321329,"IMMP2L","inner mitochondrial membrane peptidase subunit 2",TRUE
+"200955_at",0.774230543658252,0.287570973696936,-1.08966404606733,-5.37733829074944,-0.283330997003837,"IMMT","inner membrane mitochondrial protein",TRUE
+"221688_s_at",0.717613212957928,0.193384784265608,-1.34138223485876,-5.09936153441522,-0.418494029151304,"IMP3","IMP3, U3 small nucleolar ribonucleoprotein",TRUE
+"212411_at",0.872238421308015,0.515190337046158,-0.661376492563349,-5.72884952049535,-0.218746773111295,"IMP4","IMP4 homolog, U3 small nucleolar ribonucleoprotein",TRUE
+"203011_at",0.816800680706682,0.368934543023825,0.917160377413743,-5.53807457750433,0.337760955028621,"IMPA1","inositol monophosphatase 1",TRUE
+"203126_at",0.68713870484566,0.155764007459664,1.46946412926628,-4.93935760745772,0.938518347236718,"IMPA2","inositol monophosphatase 2",TRUE
+"222698_s_at",0.92051722798026,0.6621423718514,-0.442885496091414,-5.84459618230556,-0.186495413338946,"IMPACT","impact RWD domain protein",TRUE
+"218637_at",0.995288275242057,0.97814037299646,-0.0277114561328473,-5.93930945981331,-0.0132259768801362,"IMPACT","impact RWD domain protein",TRUE
+"218516_s_at",0.776955214137673,0.295567449448334,-1.07129618175064,-5.39563769089135,-0.570720466582955,"IMPAD1","inositol monophosphatase domain containing 1",TRUE
+"224744_at",0.842167419664876,0.435465498537605,-0.794266352823459,-5.63699963561505,-0.332367266374447,"IMPAD1","inositol monophosphatase domain containing 1",TRUE
+"224743_at",0.849935057946582,0.451731144491809,-0.766049900055949,-5.6578309893066,-0.292965021826612,"IMPAD1","inositol monophosphatase domain containing 1",TRUE
+"222654_at",0.896229101808264,0.579732473165385,-0.56203741610732,-5.78698723225184,-0.262218695118117,"IMPAD1","inositol monophosphatase domain containing 1",TRUE
+"227774_s_at",0.945432830098469,0.75331785324084,0.318193556793491,-5.89048969123918,0.243086467748836,"IMPAD1","inositol monophosphatase domain containing 1",TRUE
+"222655_s_at",0.968451827985008,0.851763528416072,0.189064356683446,-5.92228822975508,0.135585978505843,"IMPAD1","inositol monophosphatase domain containing 1",TRUE
+"204169_at",0.971242929121865,0.863535762772409,0.173883716751402,-5.92496758155292,0.0513884186986573,"IMPDH1","inosine monophosphate dehydrogenase 1",TRUE
+"201892_s_at",0.950214160603623,0.77413975316472,0.290494239588646,-5.89866510705621,0.148599560609867,"IMPDH2","inosine monophosphate dehydrogenase 2",TRUE
+"207054_at",0.885929137203218,0.548046964710442,0.610031737691943,-5.76003594176753,0.541522310151978,"IMPG1","interphotoreceptor matrix proteoglycan 1",TRUE
+"220830_at",0.441719101781864,0.0204640966586824,2.4964594213464,-3.2890271722206,1.85836409926951,"IMPG2","interphotoreceptor matrix proteoglycan 2",TRUE
+"241856_at",0.888972420461865,0.556423908172088,-0.597206566929521,-5.76744685995341,-0.455892174154456,"IMPG2","interphotoreceptor matrix proteoglycan 2",TRUE
+"204465_s_at",0.189644672791897,0.0019010853390208,3.52279389469148,-1.22259393114268,2.66831675347336,"INA","internexin neuronal intermediate filament protein alpha",TRUE
+"227325_at",0.810244675474564,0.353929100765597,-0.946848042833083,-5.51220740160829,-0.412847163718189,"INAFM1","InaF motif containing 1",TRUE
+"231431_s_at",0.822850703882235,0.388304410344251,0.880000334871575,-5.56938022092,0.399710601308657,"INAFM2","InaF motif containing 2",TRUE
+"225567_at",0.941400961503247,0.738035541625748,0.338685186397092,-5.88396752460912,0.175759763870641,"INAFM2","InaF motif containing 2",TRUE
+"219769_at",0.859465912277024,0.476836561189049,0.723675527421721,-5.6877747675726,0.255658860136625,"INCENP","inner centromere protein",TRUE
+"207252_at",0.627092759817312,0.0980674969123271,-1.72709550475579,-4.58272606324887,-1.17542293710908,"INE1","inactivation escape 1 (non-protein coding)",TRUE
+"218144_s_at",0.760638579081836,0.259804538553219,1.15647462455752,-5.30845311394897,0.482685020327084,"INF2","inverted formin, FH2 and WH2 domain containing",TRUE
+"224469_s_at",0.84772210282622,0.446990525275226,-0.774208703603551,-5.65188062549841,-0.455728721009521,"INF2","inverted formin, FH2 and WH2 domain containing",TRUE
+"222535_at",0.89739147209919,0.583953173893517,-0.55574615225349,-5.79036154333033,-0.566366569291141,"INF2","inverted formin, FH2 and WH2 domain containing",TRUE
+"222534_s_at",0.915569510513076,0.643978320204656,0.468535764079189,-5.83332252391564,0.28859350534418,"INF2","inverted formin, FH2 and WH2 domain containing",TRUE
+"208415_x_at",0.501591596209182,0.0321652964241728,2.28612863792548,-3.671638348667,0.71264511380256,"ING1","inhibitor of growth family member 1",TRUE
+"210350_x_at",0.642592458809121,0.113059287209092,1.64995072627231,-4.69416954187225,1.02171016752905,"ING1","inhibitor of growth family member 1",TRUE
+"209808_x_at",0.784552021081681,0.307886030053123,1.04368331618659,-5.42262306679343,0.42665929121719,"ING1","inhibitor of growth family member 1",TRUE
+"244177_at",0.953902670233338,0.787212283428245,0.273223110084667,-5.90338906116669,0.15327611669068,"ING1","inhibitor of growth family member 1",TRUE
+"213544_at",0.661974206478491,0.129286163235634,1.57561611846894,-4.79785162437055,0.776664693954513,"ING2","inhibitor of growth family member 2",TRUE
+"205981_s_at",0.841206569659492,0.431201096389833,-0.801770594504469,-5.63134009748462,-0.326562383709488,"ING2","inhibitor of growth family member 2",TRUE
+"242293_at",0.770008266045778,0.278617077899022,1.11067369853003,-5.35606750678254,0.383594298127402,"ING3","inhibitor of growth family member 3",TRUE
+"231863_at",0.819018525257656,0.374785852156371,0.905802150964937,-5.54777032746078,0.285838680035798,"ING3","inhibitor of growth family member 3",TRUE
+"205070_at",0.891652303901657,0.561345539646077,0.58971849358706,-5.77170343687684,0.241381782098339,"ING3","inhibitor of growth family member 3",TRUE
+"230719_at",0.947326616179611,0.760526159527539,0.308576711539421,-5.89341165124684,0.302348739065676,"ING3","inhibitor of growth family member 3",TRUE
+"218234_at",0.834265235157814,0.412394815008875,-0.835428834737015,-5.60534201801335,-0.605990578734189,"ING4","inhibitor of growth family member 4",TRUE
+"48825_at",0.966313390701604,0.842880162231871,0.200549692712169,-5.92011267942786,0.0763423074372902,"ING4","inhibitor of growth family member 4",TRUE
+"228287_at",0.661974206478491,0.129385611687944,-1.57518515282181,-4.79844188778974,-0.681998902812586,"ING5","inhibitor of growth family member 5",TRUE
+"229197_at",0.799008022536007,0.333526012346728,-0.988613965953925,-5.4745405476613,-0.604818807553056,"ING5","inhibitor of growth family member 5",TRUE
+"241447_at",0.925375904025762,0.676655915030338,-0.42260588238659,-5.85306847671138,-0.273150396712801,"ING5","inhibitor of growth family member 5",TRUE
+"228672_at",0.96200396340887,0.827318117420078,-0.220737644051116,-5.91597910401984,-0.153079025512771,"ING5","inhibitor of growth family member 5",TRUE
+"223871_x_at",0.96569241146864,0.839566002458776,-0.204841576102762,-5.91926691739344,-0.0472596360280857,"ING5","inhibitor of growth family member 5",TRUE
+"224245_at",0.794620886196317,0.32674154207114,1.00289002173789,-5.46132628725436,0.644012561633256,"INGX","inhibitor of growth family, X-linked (pseudogene)",TRUE
+"210141_s_at",0.791646964605038,0.322154473176132,1.01265918616814,-5.45218471022092,0.642173838818065,"INHA","inhibin alpha subunit",TRUE
+"210511_s_at",0.0550194051692779,0.000100194637414407,4.72829549487182,1.37027343465366,6.65115016795117,"INHBA","inhibin beta A subunit",TRUE
+"227140_at",0.0863592740497281,0.000323797918247723,4.24944256623999,0.338036815958527,6.10732096554792,"INHBA","inhibin beta A subunit",TRUE
+"204926_at",0.360736459722853,0.0103278866225226,2.80272577698014,-2.70173878280647,2.3477683093846,"INHBA","inhibin beta A subunit",TRUE
+"1557850_at",0.949613960042259,0.772283214143192,0.292954265251654,-5.89796888276104,0.111617209764524,"INHBA-AS1","INHBA antisense RNA 1",TRUE
+"1559163_at",0.9855380892974,0.930326325831137,0.0884338346057648,-5.93587510027995,0.0807509753060227,"INHBA-AS1","INHBA antisense RNA 1",TRUE
+"205258_at",0.855405088766616,0.46840070806613,-0.737762925664135,-5.6779991701055,-1.00660232725144,"INHBB","inhibin beta B subunit",TRUE
+"207687_at",0.758189649141895,0.255134936396861,1.16822009642958,-5.29597009304636,0.335865400817892,"INHBC","inhibin beta C subunit",TRUE
+"207688_s_at",0.942502815705589,0.741854693290326,0.333550662504539,-5.88563956880242,0.115584831765894,"INHBC","inhibin beta C subunit",TRUE
+"210587_at",0.597654932724127,0.074855665696361,1.86930387692257,-4.36751967168097,1.52285382403983,"INHBE","inhibin beta E subunit",TRUE
+"235917_at",0.597654932724127,0.0750798999566551,-1.8677569592324,-4.36992629431568,-0.707321735443394,"INIP","INTS3 and NABP interacting protein",TRUE
+"1560558_at",0.784789297644843,0.308896465664189,1.04145340358743,-5.42477467619585,0.938557698373852,"INIP","INTS3 and NABP interacting protein",TRUE
+"223558_at",0.941311073534434,0.737424212324732,-0.339507925556868,-5.88369725346315,-0.142420579493725,"INIP","INTS3 and NABP interacting protein",TRUE
+"223559_s_at",0.948109877411639,0.764149812561084,-0.303753525087061,-5.89484366313262,-0.0964126467151125,"INIP","INTS3 and NABP interacting protein",TRUE
+"239363_at",0.998870448604467,0.995179172960347,0.00611058634813437,-5.93966529418592,0.00235968259989239,"INIP","INTS3 and NABP interacting protein",TRUE
+"224061_at",0.999032205390192,0.996930903083473,0.00389018502950637,-5.93967610976264,0.00293568481523643,"INMT","indolethylamine N-methyltransferase",TRUE
+"235559_at",0.67606695078322,0.142507517402591,1.52058451711774,-4.87219278183658,0.539423755621536,"INMT-FAM188B///FAM188B","INMT-FAM188B readthrough (NMD candidate)///family with sequence similarity 188 member B",TRUE
+"1557141_at",0.731288567040689,0.214337435515812,1.27840254693428,-5.17355437050901,0.500955741285009,"INMT-FAM188B///FAM188B///INMT","INMT-FAM188B readthrough (NMD candidate)///family with sequence similarity 188 member B///indolethylamine N-methyltransferase",TRUE
+"225357_s_at",0.900485723974959,0.595415818804622,0.538773062136144,-5.7992810006277,0.14716532278459,"INO80","INO80 complex subunit",TRUE
+"229356_x_at",0.910206474192635,0.626883712086222,-0.492970475094421,-5.82200563452414,-0.126659533130788,"INO80","INO80 complex subunit",TRUE
+"222093_s_at",0.961876388239691,0.826824458671987,0.221379538137272,-5.91584120405067,0.0748025159796146,"INO80B","INO80 complex subunit B",TRUE
+"221251_x_at",0.811844013927892,0.355981323679188,0.942738532712573,-5.51583318392696,0.493952034503635,"INO80B-WBP1///INO80B","INO80B-WBP1 readthrough (NMD candidate)///INO80 complex subunit B",TRUE
+"65133_i_at",0.997039490727282,0.984800347904778,-0.0192672725231165,-5.93950267099691,-0.00636718011000958,"INO80B-WBP1///INO80B","INO80B-WBP1 readthrough (NMD candidate)///INO80 complex subunit B",TRUE
+"223072_s_at",0.360736459722853,0.0103651939318629,-2.80114119953644,-2.70485717700191,-1.44411533089338,"INO80B-WBP1///INO80B///WBP1","INO80B-WBP1 readthrough (NMD candidate)///INO80 complex subunit B///WW domain binding protein 1",TRUE
+"229582_at",0.819018525257656,0.375208156878596,0.904986952112656,-5.54846191770814,0.305699307680136,"INO80C","INO80 complex subunit C",TRUE
+"1559716_at",0.865854896594418,0.496059493997657,0.692107660322751,-5.70902886535265,0.200867380476959,"INO80C","INO80 complex subunit C",TRUE
+"226555_at",0.346875625018457,0.00892296403141419,-2.86674907187062,-2.57512178831017,-0.850378386751429,"INO80D","INO80 complex subunit D",TRUE
+"243070_at",0.552281323843226,0.049484991319184,-2.07812947483998,-4.03020889913254,-1.24132205079706,"INO80D","INO80 complex subunit D",TRUE
+"220165_at",0.609539262323192,0.0818231287351943,1.82301890656868,-4.43891355745813,0.628504585353188,"INO80D","INO80 complex subunit D",TRUE
+"227924_at",0.731965025847759,0.215585668500555,-1.27480385885166,-5.17770225553044,-0.349475116636989,"INO80D","INO80 complex subunit D",TRUE
+"227931_at",0.94895689004559,0.768892127682155,0.297452439631328,-5.89668077584542,0.11410476708584,"INO80D","INO80 complex subunit D",TRUE
+"231152_at",0.955515814503015,0.796106454808749,-0.261520997947056,-5.90642645178411,-0.179931968246024,"INO80D","INO80 complex subunit D",TRUE
+"227286_at",0.610033432202476,0.0825730797600037,-1.81824325008484,-4.44620697325175,-0.565663123091193,"INO80E","INO80 complex subunit E",TRUE
+"202794_at",0.657015752622694,0.126040232580144,1.58983605970775,-4.77830477486463,1.35666951114472,"INPP1","inositol polyphosphate-1-phosphatase",TRUE
+"208363_s_at",0.600908707233561,0.0767030977189396,1.85667766149525,-4.38712171433377,0.764767704116249,"INPP4A","inositol polyphosphate-4-phosphatase type I A",TRUE
+"227087_at",0.632949074657601,0.103899384100809,1.69596951966324,-4.62815257121162,0.691713422127249,"INPP4A","inositol polyphosphate-4-phosphatase type I A",TRUE
+"204553_x_at",0.643515428391208,0.114171421584537,1.64457983984446,-4.70178423604869,0.983226874995953,"INPP4A","inositol polyphosphate-4-phosphatase type I A",TRUE
+"208364_at",0.677013732819214,0.144287212400447,1.51350143364494,-4.8816087186429,0.667639136075216,"INPP4A","inositol polyphosphate-4-phosphatase type I A",TRUE
+"204552_at",0.751284074249149,0.244189653104374,1.19639170379312,-5.26558041658248,0.322244250391071,"INPP4A","inositol polyphosphate-4-phosphatase type I A",TRUE
+"235695_at",0.935414597731663,0.712801197484242,0.372852649103568,-5.87219830757621,0.146334440080831,"INPP4A","inositol polyphosphate-4-phosphatase type I A",TRUE
+"1563833_at",0.526253358601247,0.039549117307868,2.1873941267371,-3.84447630356454,1.60103631336362,"INPP4B","inositol polyphosphate-4-phosphatase type II B",TRUE
+"223878_at",0.819807973515613,0.377819137435665,0.899960222956098,-5.55271373047851,0.485171524028682,"INPP4B","inositol polyphosphate-4-phosphatase type II B",TRUE
+"205376_at",0.917113901833643,0.649733010680791,0.460375549433917,-5.83697650025716,0.298117024509153,"INPP4B","inositol polyphosphate-4-phosphatase type II B",TRUE
+"235046_at",0.984798640722849,0.925306926352973,0.0948240588332383,-5.93530495161238,0.0629244681389718,"INPP4B","inositol polyphosphate-4-phosphatase type II B",TRUE
+"203006_at",0.771855357662161,0.282007092208817,1.10266252934664,-5.36422083277264,0.563712406167811,"INPP5A","inositol polyphosphate-5-phosphatase A",TRUE
+"1554757_a_at",0.780804513841697,0.302564697945233,1.05551318363108,-5.41113943766015,0.592340001622357,"INPP5A","inositol polyphosphate-5-phosphatase A",TRUE
+"1563565_at",0.194851690348607,0.00209552435162288,3.48231215878852,-1.30826936097334,1.95381195991603,"INPP5B","inositol polyphosphate-5-phosphatase B",TRUE
+"213643_s_at",0.888972420461865,0.556480555177354,0.597120185262265,-5.7674962593055,0.469771629377526,"INPP5B","inositol polyphosphate-5-phosphatase B",TRUE
+"213804_at",0.959869386255065,0.818506461089268,0.232209803503886,-5.91345443129574,0.154882793158714,"INPP5B","inositol polyphosphate-5-phosphatase B",TRUE
+"1568943_at",0.723655063748891,0.200638569616462,1.31900269880323,-5.126070792096,0.934997303850814,"INPP5D","inositol polyphosphate-5-phosphatase D",TRUE
+"203332_s_at",0.849935057946582,0.452081728007194,0.765448594345899,-5.65826717660219,0.387550157249778,"INPP5D","inositol polyphosphate-5-phosphatase D",TRUE
+"203331_s_at",0.861665593344139,0.483795265111788,-0.712164367824821,-5.69562960283544,-0.341104100048343,"INPP5D","inositol polyphosphate-5-phosphatase D",TRUE
+"204706_at",0.862800800218883,0.486844636945021,-0.70715037765089,-5.69901349413865,-0.263707832996905,"INPP5E","inositol polyphosphate-5-phosphatase E",TRUE
+"203607_at",0.691295036264984,0.161030326232652,1.45013462946855,-4.96427011842138,0.746730439946626,"INPP5F","inositol polyphosphate-5-phosphatase F",TRUE
+"230362_at",0.693742297578797,0.162882759659978,-1.44345685580848,-4.97281429862447,-0.760330502766791,"INPP5F","inositol polyphosphate-5-phosphatase F",TRUE
+"230363_s_at",0.973499570783928,0.872462070743705,0.162400992665274,-5.9268457959668,0.10426132779926,"INPP5F","inositol polyphosphate-5-phosphatase F",TRUE
+"213651_at",0.75659508440507,0.251949276666906,-1.17632493859663,-5.28729192263959,-1.53935319309914,"INPP5J","inositol polyphosphate-5-phosphatase J",TRUE
+"202781_s_at",0.747587302711183,0.239470110296153,1.20883162716057,-5.25196050051329,0.334996870833413,"INPP5K","inositol polyphosphate-5-phosphatase K",TRUE
+"202782_s_at",0.868397087637799,0.504094142018167,0.679121174982203,-5.71750978743525,0.221403147526239,"INPP5K","inositol polyphosphate-5-phosphatase K",TRUE
+"201598_s_at",0.714054210868775,0.189131541186764,-1.3548123416422,-5.0831521960374,-0.633802481389948,"INPPL1","inositol polyphosphate phosphatase like 1",TRUE
+"206598_at",0.979588787486838,0.902718530091265,0.123635594425408,-5.9322410919005,0.0435910895884692,"INS","insulin",TRUE
+"202409_at",0.864894115958506,0.493978956928036,0.695489921507993,-5.70679487487289,0.604462981999672,"INS-IGF2///IGF2","INS-IGF2 readthrough///insulin like growth factor 2",TRUE
+"210881_s_at",0.974884920935236,0.877405344113052,-0.156051713811843,-5.92782940831231,-0.0797327820127274,"INS-IGF2///IGF2","INS-IGF2 readthrough///insulin like growth factor 2",TRUE
+"202410_x_at",0.991367768700244,0.959798036796966,0.0509802946663295,-5.93841768760805,0.0180102822149029,"INS-IGF2///IGF2","INS-IGF2 readthrough///insulin like growth factor 2",TRUE
+"237056_at",0.816800680706682,0.368561999393525,-0.917887573339977,-5.53745002467307,-0.683820539158378,"INSC","inscuteable homolog (Drosophila)",TRUE
+"201626_at",0.407748633394319,0.015532776281268,-2.62144033851395,-3.05330975976738,-1.5865758094276,"INSIG1","insulin induced gene 1",TRUE
+"201627_s_at",0.527546822913581,0.0401404967080974,-2.18023145927366,-3.85683402219528,-1.30912117498727,"INSIG1","insulin induced gene 1",TRUE
+"201625_s_at",0.62986301194198,0.100965479973127,-1.71143705341852,-4.60565594288265,-0.988343324715663,"INSIG1","insulin induced gene 1",TRUE
+"209566_at",0.94370161759716,0.748085822097306,0.325192959862937,-5.88830718014072,0.183286760021721,"INSIG2","insulin induced gene 2",TRUE
+"214572_s_at",0.549090387808109,0.0485870927520006,2.08714871102668,-4.01510749475618,1.18530729745249,"INSL3","insulin like 3",TRUE
+"214400_at",0.761006638483723,0.260090021290519,1.15576163803482,-5.30920730869666,0.818086024975101,"INSL3","insulin like 3",TRUE
+"1553594_a_at",0.90998880119877,0.625467043168906,-0.4950089496011,-5.82103611493295,-0.134859391526089,"INSL3","insulin like 3",TRUE
+"206549_at",0.691295036264984,0.16103033528799,1.45013459667413,-4.96427016046053,1.15422701551441,"INSL4","insulin like 4",TRUE
+"221091_at",0.718812966125406,0.194865034913777,1.33676259732758,-5.10490586224739,0.824192822275235,"INSL5","insulin like 5",TRUE
+"221403_s_at",0.861113073516266,0.481330917379165,0.716229822954054,-5.69286915819745,0.494172443517266,"INSL6","insulin like 6",TRUE
+"206502_s_at",0.710842845257879,0.184549741865057,-1.36954883300066,-5.06521098440739,-2.55911428747264,"INSM1","INSM transcriptional repressor 1",TRUE
+"231558_at",0.955816406528307,0.798646111144361,-0.258186466934046,-5.90726778392955,-0.181791103813922,"INSM1","INSM transcriptional repressor 1",TRUE
+"240841_at",0.728262401376535,0.208455445548364,1.29558147522074,-5.15361662885001,0.918809218361486,"INSM2","INSM transcriptional repressor 2",TRUE
+"226216_at",0.663789119801086,0.131726870883468,1.56511767796554,-4.8121945519271,0.710059025786696,"INSR","insulin receptor",TRUE
+"213792_s_at",0.70772084164277,0.179349063594264,1.38663079213769,-5.04421228583372,0.96828430419527,"INSR","insulin receptor",TRUE
+"226212_s_at",0.819018525257656,0.374540926074388,0.90627522379602,-5.54736872295992,0.444125050592439,"INSR","insulin receptor",TRUE
+"207851_s_at",0.892619958073408,0.564909662354935,0.584317004881726,-5.77474165442936,0.412292501217831,"INSR","insulin receptor",TRUE
+"226450_at",0.931370027472813,0.696389762512681,0.39531636196899,-5.86385299502857,0.195946987736075,"INSR","insulin receptor",TRUE
+"215776_at",0.754491163266461,0.247750138783881,1.18712578284741,-5.27564559360155,0.550075934105572,"INSRR","insulin receptor related receptor",TRUE
+"212212_s_at",0.635916735157933,0.107162865433348,1.67919413254879,-4.65237737842078,0.605140762988249,"INTS1","integrator complex subunit 1",TRUE
+"212210_at",0.682478351554273,0.149901829425062,1.49161441058914,-4.91048189789153,1.253569804141,"INTS1","integrator complex subunit 1",TRUE
+"1560172_at",0.707898177720919,0.179889972292732,1.38483597357159,-5.04642879469124,1.19641079102536,"INTS10","integrator complex subunit 10",TRUE
+"229632_s_at",0.949259609170322,0.770995607146111,-0.294661505526001,-5.89748228549324,-0.104507999204296,"INTS10","integrator complex subunit 10",TRUE
+"229633_at",0.951463178368216,0.777754802575412,0.285709313865681,-5.90000263191165,0.147741154816332,"INTS10","integrator complex subunit 10",TRUE
+"237504_at",0.966593471043185,0.84415056041385,0.198905534973453,-5.92043195266278,0.0945619150321617,"INTS10","integrator complex subunit 10",TRUE
+"218616_at",0.849646596450765,0.451103038642997,-0.767127905966166,-5.65704819349526,-0.245413684573155,"INTS12","integrator complex subunit 12",TRUE
+"224308_s_at",0.897710071620737,0.585288289094444,-0.553760788132535,-5.79141873829956,-0.279070404235878,"INTS2","integrator complex subunit 2",TRUE
+"202809_s_at",0.642592458809121,0.113098623340104,-1.64976000131315,-4.69444027169091,-0.532986904450041,"INTS3","integrator complex subunit 3",TRUE
+"211132_at",0.929325066560006,0.689259178284412,-0.405140794554771,-5.86005207591678,-0.236800037445452,"INTS3","integrator complex subunit 3",TRUE
+"225169_at",0.758081075834994,0.254858869248616,1.1689194679016,-5.29522331871144,0.374371955767206,"INTS4","integrator complex subunit 4",TRUE
+"1569253_at",0.784925710185113,0.310250208833244,1.03847391418019,-5.42764307547308,0.5413939330394,"INTS4","integrator complex subunit 4",TRUE
+"233193_x_at",0.819018525257656,0.374028510229688,0.907265612785247,-5.54652732756098,0.251078910414694,"INTS4","integrator complex subunit 4",TRUE
+"1569254_s_at",0.979588787486838,0.902385896076097,0.124060610123875,-5.93218985432031,0.104631287701334,"INTS4","integrator complex subunit 4",TRUE
+"1553670_at",0.987967825391489,0.942463714508587,0.0729967039805426,-5.93708848892982,0.0269869981030846,"INTS4","integrator complex subunit 4",TRUE
+"1563887_at",0.996261754016157,0.981855542442062,0.0230007776200613,-5.93942581021539,0.0150219077151585,"INTS4P1","integrator complex subunit 4 pseudogene 1",TRUE
+"53968_at",0.610455440146151,0.0830656292282845,-1.81512711452149,-4.45095852769683,-0.514945166239306,"INTS5","integrator complex subunit 5",TRUE
+"221818_at",0.641880516735663,0.112200023889828,-1.65413095412337,-4.68822979589683,-0.49616118459722,"INTS5","integrator complex subunit 5",TRUE
+"235283_at",0.925504446660705,0.677300391471484,0.421709589917206,-5.85343392272965,0.167665538817674,"INTS6","integrator complex subunit 6",TRUE
+"222239_s_at",0.945498722604777,0.754256716828415,-0.316939271233146,-5.89087582672507,-0.135196091908085,"INTS6","integrator complex subunit 6",TRUE
+"1568695_s_at",0.957017346544368,0.805358129738853,0.249387958662167,-5.90943622310533,0.105931856602945,"INTS6","integrator complex subunit 6",TRUE
+"218819_at",0.980832655742,0.910241407450372,-0.114029475586051,-5.93335231838017,-0.057045793934698,"INTS6","integrator complex subunit 6",TRUE
+"1557117_at",0.774230543658252,0.288089427981659,-1.08846210005379,-5.37854424179296,-0.618701533853381,"INTS6-AS1","INTS6 antisense RNA 1",TRUE
+"1557118_a_at",0.904885221062616,0.610369292860725,0.516868277043367,-5.81039424053787,0.248941655067693,"INTS6-AS1","INTS6 antisense RNA 1",TRUE
+"227485_at",0.646561172018775,0.117510349636042,-1.62871504216271,-4.72416562771076,-1.19218904696162,"INTS6L","integrator complex subunit 6 like",TRUE
+"222250_s_at",0.680708651141727,0.14840203696809,-1.49739449506519,-4.90288963143309,-0.60402568203566,"INTS7","integrator complex subunit 7",TRUE
+"218783_at",0.895690630367785,0.576330469023862,-0.567125078437657,-5.78423153021403,-0.234626106147039,"INTS7","integrator complex subunit 7",TRUE
+"1570173_at",0.97070558355376,0.860531169785957,0.177754109315502,-5.92430568650798,0.077463021959467,"INTS7","integrator complex subunit 7",TRUE
+"218905_at",0.702621412021935,0.174053693295191,-1.40443307362144,-5.02209886355901,-0.614954935212763,"INTS8","integrator complex subunit 8",TRUE
+"203941_at",0.837839105061376,0.422514825167718,0.817199948319719,-5.61954663124146,0.25207185230628,"INTS9","integrator complex subunit 9",TRUE
+"237286_at",0.931370027472813,0.696651204178137,0.394956908178634,-5.86399031956008,0.267170445615007,"INTS9","integrator complex subunit 9",TRUE
+"228946_at",0.785440072877511,0.310971663251341,1.0368897924787,-5.42916511976696,0.466588219001114,"INTU","inturned planar cell polarity protein",TRUE
+"211054_at",0.692529423238777,0.162021384322256,1.44655433696686,-4.9688550807282,1.27958541248417,"INVS","inversin",TRUE
+"211055_s_at",0.877944644261883,0.529493309936026,0.638813330257442,-5.74285252400139,0.383838450123942,"INVS","inversin",TRUE
+"210114_at",0.925091998149497,0.675786105674161,0.423816110513862,-5.85257381941542,0.145583436225412,"INVS","inversin",TRUE
+"235031_at",0.99783553534859,0.98928205217235,0.0135857654278837,-5.93959358243494,0.00466254166578928,"INVS///WSB1","inversin///WD repeat and SOCS box containing 1",TRUE
+"212439_at",0.597654932724127,0.0748163751210471,-1.86957534575219,-4.36709718792231,-0.675190068704008,"IP6K1","inositol hexakisphosphate kinase 1",TRUE
+"223165_s_at",0.531571149526209,0.0417673462892472,-2.16100941108327,-3.88987352745149,-1.01305031726734,"IP6K2","inositol hexakisphosphate kinase 2",TRUE
+"218192_at",0.797960028258877,0.33204185830668,-0.991719680633777,-5.47168047441242,-0.449664240131229,"IP6K2","inositol hexakisphosphate kinase 2",TRUE
+"231179_at",0.812432515576345,0.360991962202318,-0.932771468800503,-5.52456688718392,-0.833617362537644,"IP6K3","inositol hexakisphosphate kinase 3",TRUE
+"214735_at",0.610455440146151,0.0829291157280146,1.81598916709224,-4.44964463808231,1.60435917009953,"IPCEF1","interaction protein for cytohesin exchange factors 1",TRUE
+"238739_at",0.575177240488242,0.0607420829735548,-1.97595747179182,-4.19826484444343,-0.821089365943773,"IPMK","inositol polyphosphate multikinase",TRUE
+"239878_at",0.865281911695705,0.494575674849611,-0.694519025770243,-5.70743721719325,-0.397607025721499,"IPMK","inositol polyphosphate multikinase",TRUE
+"1557770_at",0.939356991756184,0.728487475933613,0.351562820506757,-5.87966286686614,0.283873809382024,"IPO11","importin 11",TRUE
+"222659_at",0.921729477898827,0.66610066531041,0.437336235307158,-5.84695326216918,0.156877751172852,"IPO11-LRRC70///IPO11","IPO11-LRRC70 readthrough///importin 11",TRUE
+"234304_s_at",0.992820830895496,0.966190181986414,-0.0428687030850953,-5.93878843195427,-0.0164650342990154,"IPO11-LRRC70///IPO11","IPO11-LRRC70 readthrough///importin 11",TRUE
+"203546_at",0.702630084418366,0.174180968118711,-1.40400016390312,-5.02263937298493,-0.318350623246614,"IPO13","importin 13",TRUE
+"218305_at",0.81031378318664,0.35406303210478,-0.946579359876054,-5.5124448998913,-0.412703023334753,"IPO4","importin 4",TRUE
+"209150_s_at",0.788413816943444,0.314621326608994,-1.02891553781708,-5.4367950732032,-0.420455636533807,"IPO4///TM9SF1","importin 4///transmembrane 9 superfamily member 1",TRUE
+"211953_s_at",0.699391325858549,0.170952782417969,1.41505941424506,-5.00878833051627,0.801830092764888,"IPO5","importin 5",TRUE
+"211955_at",0.700061364939874,0.171524539271049,1.41308856959026,-5.01126324287472,0.655774331521892,"IPO5","importin 5",TRUE
+"211954_s_at",0.742096120237291,0.232557383157673,1.22739052008693,-5.23141437834957,0.64102003021819,"IPO5","importin 5",TRUE
+"211952_at",0.8877101263145,0.552661566566995,0.602954122506851,-5.76414448096758,0.303684995870547,"IPO5","importin 5",TRUE
+"236906_x_at",0.9114480626414,0.62964504463295,0.489003204701156,-5.82388130385392,0.13887741625993,"IPO5","importin 5",TRUE
+"1565748_at",0.663505464670568,0.131439006636432,1.56634746708108,-4.81051831197636,0.593837215738415,"IPO5P1","importin 5 pseudogene 1",TRUE
+"1565746_at",0.758966211371161,0.256502149124594,1.16476474586363,-5.29965389951118,0.729143168881829,"IPO5P1","importin 5 pseudogene 1",TRUE
+"227234_at",0.840846485760608,0.430148491662738,0.803629968272883,-5.62993006577437,0.334588169739769,"IPO5P1","importin 5 pseudogene 1",TRUE
+"1560446_at",0.8920930097751,0.563576479024639,0.586335404851435,-5.77360951372948,0.183277959793069,"IPO5P1","importin 5 pseudogene 1",TRUE
+"200994_at",0.786455312223125,0.312211080354439,-1.03417440120257,-5.43176923213553,-0.352590990049148,"IPO7","importin 7",TRUE
+"200993_at",0.913300726876965,0.636558858104469,-0.479104599023927,-5.82849662624064,-0.143676021202078,"IPO7","importin 7",TRUE
+"200995_at",0.9181984176728,0.652766346769772,-0.456087019246894,-5.83887160181656,-0.210562145747764,"IPO7","importin 7",TRUE
+"200992_at",0.952613441433926,0.782659424802879,-0.279228342314192,-5.90177910369558,-0.0940986983871017,"IPO7","importin 7",TRUE
+"205701_at",0.70939075283402,0.182329979150799,1.37679250162662,-5.05633281089532,0.463377856027563,"IPO8","importin 8",TRUE
+"225528_at",0.82706053436911,0.395573153532887,0.8663688138466,-5.58056319178117,0.282377644865372,"IPO8","importin 8",TRUE
+"242561_at",0.711902920992134,0.185452435727727,-1.36662281415472,-5.06878619397715,-0.505952981059017,"IPO9","importin 9",TRUE
+"213785_at",0.852006864319744,0.457350818036185,-0.75644494306619,-5.66475969855827,-0.374255378122289,"IPO9","importin 9",TRUE
+"217885_at",0.859064198633089,0.475579058850243,-0.725766142373991,-5.68633535106441,-0.24457722579376,"IPO9","importin 9",TRUE
+"244703_x_at",0.91876780831279,0.654981884658464,-0.452960175983075,-5.84024239549584,-0.227181141355062,"IPO9","importin 9",TRUE
+"233567_at",0.691446132026237,0.161116117457965,1.44982399848795,-4.96466828143623,0.684420286154891,"IPO9-AS1","IPO9 antisense RNA 1",TRUE
+"241434_at",0.50789985308763,0.0334166117321576,-2.26802928866794,-3.70366291746069,-0.980296123253551,"IPP","intracisternal A particle-promoted polypeptide",TRUE
+"241393_at",0.642395416317759,0.112441227876744,-1.65295480663691,-4.68990216160132,-0.575258261469934,"IPP","intracisternal A particle-promoted polypeptide",TRUE
+"219843_at",0.787781415608703,0.313535458307917,-1.0312812495899,-5.43453704646162,-0.321505532820916,"IPP","intracisternal A particle-promoted polypeptide",TRUE
+"1554740_a_at",0.886023097762234,0.548500042057076,-0.609335446809742,-5.76044218883525,-0.177951847872933,"IPP","intracisternal A particle-promoted polypeptide",TRUE
+"1554739_at",0.96350209729653,0.833572495771751,0.212613317557292,-5.91769002626468,0.125115573790102,"IPP","intracisternal A particle-promoted polypeptide",TRUE
+"219092_s_at",0.517859245504688,0.0369573213449691,-2.21997867514558,-3.78794516669834,-0.890654025825619,"IPPK","inositol-pentakisphosphate 2-kinase",TRUE
+"222823_at",0.895690630367785,0.575818377459481,-0.567892214079583,-5.78381392697462,-0.326925587100274,"IPPK","inositol-pentakisphosphate 2-kinase",TRUE
+"220274_at",0.70939075283402,0.182235486943889,1.37710240105682,-5.05595211554199,0.94910925753216,"IQCA1","IQ motif containing with AAA domain 1",TRUE
+"1557642_at",0.883159445713297,0.540992705182071,0.620912359428058,-5.75362959631619,0.658636917193443,"IQCA1","IQ motif containing with AAA domain 1",TRUE
+"238584_at",0.928139121708712,0.684166273840443,0.412182598520135,-5.85727121445314,0.439680259832638,"IQCA1","IQ motif containing with AAA domain 1",TRUE
+"1562130_at",0.954821391098138,0.794488237158092,0.263647272623447,-5.90588437366967,0.091243333399766,"IQCA1","IQ motif containing with AAA domain 1",TRUE
+"1561485_at",0.996243927234326,0.981237898238623,0.0237838845669116,-5.93940796596236,0.0226074736543769,"IQCA1","IQ motif containing with AAA domain 1",TRUE
+"205995_x_at",0.872668627020452,0.516214967286714,0.659748732959075,-5.7298753358814,0.215392926904787,"IQCB1","IQ motif containing B1",TRUE
+"211707_s_at",0.913627134030439,0.637862833019089,0.477243139825745,-5.82935423936874,0.15412903162308,"IQCB1","IQ motif containing B1",TRUE
+"206650_at",0.849650943868202,0.451158046682792,0.767033460478984,-5.65711681680845,0.508910031918727,"IQCC","IQ motif containing C",TRUE
+"1552540_s_at",0.61400463972392,0.0849023127928558,1.80364647191588,-4.46841367212597,0.515118188693719,"IQCD","IQ motif containing D",TRUE
+"204202_at",0.913123070637484,0.635060301214963,-0.481245952516331,-5.82750602138594,-0.220748603735808,"IQCE","IQ motif containing E",TRUE
+"217124_at",0.94333312187812,0.745496056669982,0.328663663032505,-5.88720753406029,0.154642558880666,"IQCE","IQ motif containing E",TRUE
+"1555001_at",0.838999550222784,0.424528042395591,0.813606403857569,-5.6223122065848,0.348771339900614,"IQCF1","IQ motif containing F1",TRUE
+"1552997_a_at",0.936143408699214,0.715272781501865,-0.369486734001178,-5.87340727732341,-0.0917705068541501,"IQCF1","IQ motif containing F1",TRUE
+"236767_at",0.942324052902057,0.740958190891926,0.334755107339449,-5.88524961281144,0.209899079958933,"IQCF2","IQ motif containing F2",TRUE
+"1555235_s_at",0.981158705865426,0.911224520719024,0.112774949164847,-5.93349081764293,0.106515293828207,"IQCF3","IQ motif containing F3",TRUE
+"236870_at",0.801455134542848,0.338135598277885,0.979028321270255,-5.48331653800552,0.859178411732958,"IQCF4","IQ motif containing F5 pseudogene",TRUE
+"236871_s_at",0.941908206900417,0.73910723000729,0.337243461422707,-5.88443956958167,0.189993211542517,"IQCF4///IQCF3","IQ motif containing F5 pseudogene///IQ motif containing F3",TRUE
+"231525_at",0.93443775297996,0.709318153853265,0.377603485097088,-5.87047349452225,0.267403412346332,"IQCF5","IQ motif containing F5",TRUE
+"1564300_at",0.980808506518944,0.909837474989464,0.114544977985262,-5.93329496351033,0.0640914344491224,"IQCF5-AS1","IQCF5 antisense RNA 1",TRUE
+"236661_at",0.808257777979515,0.350854021121872,0.953036034138136,-5.50672052941295,0.373395110218293,"IQCF6","IQ motif containing F6",TRUE
+"221185_s_at",0.42327301158031,0.0177311511682429,2.56171440835853,-3.16667851087465,1.41103490533231,"IQCG","IQ motif containing G",TRUE
+"1553757_at",0.935318317015903,0.71243286018188,-0.373354642430459,-5.8720170745637,-0.24025387512854,"IQCG","IQ motif containing G",TRUE
+"224165_s_at",0.304349626214253,0.00588938096999871,-3.0464131346542,-2.21381478142039,-1.51456707872018,"IQCH","IQ motif containing H",TRUE
+"220361_at",0.389015468142133,0.0129223370544089,-2.70367733920466,-2.89516156479948,-2.30089548527656,"IQCH","IQ motif containing H",TRUE
+"1569610_at",0.84571977676742,0.443578730663082,0.780113138079796,-5.64753731674021,0.529650086814398,"IQCH","IQ motif containing H",TRUE
+"239812_s_at",0.864079461576774,0.491224946171748,-0.699979585188553,-5.703813391329,-0.316344215538014,"IQCH","IQ motif containing H",TRUE
+"239813_at",0.871744769522775,0.514057748757876,0.66317785017757,-5.72771147909198,0.193815179166081,"IQCH","IQ motif containing H",TRUE
+"1569611_a_at",0.959395397489393,0.816508214649775,0.234815762213314,-5.9128632055924,0.150074706883337,"IQCH","IQ motif containing H",TRUE
+"238485_at",0.774230543658252,0.289428550455305,-1.08536477326915,-5.38164642093015,-0.543437333646247,"IQCH-AS1","IQCH antisense RNA 1",TRUE
+"244152_at",0.839519981963042,0.427165429155533,0.808914800539947,-5.62590563425458,0.403774907092078,"IQCJ-SCHIP1-AS1","IQCJ-SCHIP1 readthrough antisense RNA 1",TRUE
+"204030_s_at",0.63156489761582,0.102806174463298,1.701688997188,-4.61985179511646,1.54864783625993,"IQCJ-SCHIP1///SCHIP1","IQCJ-SCHIP1 readthrough///schwannomin interacting protein 1",TRUE
+"215131_at",0.768852835478002,0.272255383140934,1.12590099711774,-5.34042584862423,0.28071689758255,"IQCK","IQ motif containing K",TRUE
+"215130_s_at",0.870433264908839,0.508743901909563,0.671659077350216,-5.72231345973153,0.205096259036601,"IQCK","IQ motif containing K",TRUE
+"213392_at",0.908367146600979,0.619107212961163,-0.504186656169166,-5.81662272551452,-0.219251608984294,"IQCK","IQ motif containing K",TRUE
+"216135_at",0.937863281185201,0.725195170345985,-0.356017182221372,-5.87813694238723,-0.220807808460004,"IQCK","IQ motif containing K",TRUE
+"210840_s_at",0.776743077119289,0.294265637051204,1.07426192624951,-5.39270181403092,0.366762991011308,"IQGAP1","IQ motif containing GTPase activating protein 1",TRUE
+"213446_s_at",0.864044288984659,0.490697589650341,0.700840941751479,-5.70323929191534,0.293261024977397,"IQGAP1","IQ motif containing GTPase activating protein 1",TRUE
+"200791_s_at",0.87579870142401,0.523422389715493,0.648348910034178,-5.73699154350539,0.257180036955349,"IQGAP1","IQ motif containing GTPase activating protein 1",TRUE
+"241723_at",0.446229200741107,0.020917886447178,-2.48641965721547,-3.30770554148282,-1.6774816676364,"IQGAP2","IQ motif containing GTPase activating protein 2",TRUE
+"203474_at",0.561084367279569,0.0547073458737272,-2.02840336666194,-4.11270066346855,-3.09672864865649,"IQGAP2","IQ motif containing GTPase activating protein 2",TRUE
+"1569061_at",0.771623843789204,0.281026134504381,1.10497347588944,-5.36187425720052,1.23994213831799,"IQGAP3","IQ motif containing GTPase activating protein 3",TRUE
+"241939_at",0.810417059188012,0.354538008938602,0.945627050029385,-5.51328618224897,0.317357468057185,"IQGAP3","IQ motif containing GTPase activating protein 3",TRUE
+"229538_s_at",0.884221189678062,0.543110443108147,0.61763804000594,-5.7555689492296,0.225193824377293,"IQGAP3","IQ motif containing GTPase activating protein 3",TRUE
+"1569062_s_at",0.998870448604467,0.995248186922427,0.00602310734513414,-5.93966581117496,0.00793467212095855,"IQGAP3","IQ motif containing GTPase activating protein 3",TRUE
+"203907_s_at",0.584828007864693,0.0650330506469203,-1.94140638088082,-4.25380464226389,-0.745064967989896,"IQSEC1","IQ motif and Sec7 domain 1",TRUE
+"203906_at",0.606236396254745,0.0799009549705789,-1.83543478867509,-4.41988768231138,-0.610931882869323,"IQSEC1","IQ motif and Sec7 domain 1",TRUE
+"237652_at",0.682125064335234,0.149617652087976,1.49270597535152,-4.90904991086792,0.389734140149133,"IQSEC2","IQ motif and Sec7 domain 2",TRUE
+"214819_at",0.859276375962637,0.476296714326294,-0.724572634173265,-5.68715758093113,-0.229562063710994,"IQSEC2","IQ motif and Sec7 domain 2",TRUE
+"229840_at",0.943464796017993,0.74646602846709,-0.327363264422701,-5.88762090156906,-0.12500551609735,"IQSEC2","IQ motif and Sec7 domain 2",TRUE
+"213834_at",0.479935504824714,0.0270098134128148,-2.36824558025251,-3.52449702641497,-1.1914721133062,"IQSEC3","IQ motif and Sec7 domain 3",TRUE
+"242694_at",0.774230543658252,0.289694386533226,1.08475113518307,-5.38226008475077,0.785181361158863,"IQSEC3","IQ motif and Sec7 domain 3",TRUE
+"1553949_at",0.88082806716658,0.536521285334069,0.627848387862158,-5.74948882471024,0.20585481734039,"IQSEC3","IQ motif and Sec7 domain 3",TRUE
+"1556872_s_at",0.9832781796011,0.918485201153876,-0.103515375934231,-5.93446573570776,-0.0349395453985193,"IQSEC3","IQ motif and Sec7 domain 3",TRUE
+"1568924_a_at",0.56861088242915,0.0585065024752712,-1.99482304422369,-4.16765913512361,-1.33366955236586,"IQUB","IQ motif and ubiquitin domain containing",TRUE
+"1555784_s_at",0.955904644595647,0.800512664394668,0.255737618217264,-5.90787881868864,0.101271028713191,"IRAK1","interleukin 1 receptor associated kinase 1",TRUE
+"201587_s_at",0.966064677476069,0.841969865807358,-0.201728152025621,-5.91988222778174,-0.10054801994551,"IRAK1","interleukin 1 receptor associated kinase 1",TRUE
+"238599_at",0.794620886196317,0.326720247607194,1.00293515193157,-5.46128424100505,0.53037363953142,"IRAK1BP1","interleukin 1 receptor associated kinase 1 binding protein 1",TRUE
+"1557174_a_at",0.826617572584789,0.394906308628992,0.867612594970274,-5.57954954948768,0.600927766018538,"IRAK1BP1","interleukin 1 receptor associated kinase 1 binding protein 1",TRUE
+"231779_at",0.404825645557284,0.0150823930498434,2.63465098336756,-3.02806154569984,2.23185299368091,"IRAK2","interleukin 1 receptor associated kinase 2",TRUE
+"1553740_a_at",0.629618534694136,0.100438561548254,1.71425537225238,-4.6015403770462,1.35927690137574,"IRAK2","interleukin 1 receptor associated kinase 2",TRUE
+"1553739_at",0.929126743655924,0.688295359903602,0.40647182811525,-5.85953005503065,0.265729175082442,"IRAK2","interleukin 1 receptor associated kinase 2",TRUE
+"213817_at",0.445461589563855,0.0208004286814178,2.48899872578474,-3.30291111536482,3.22465422437166,"IRAK3","interleukin 1 receptor associated kinase 3",TRUE
+"220034_at",0.452741080390362,0.0217945043180143,2.46758618826551,-3.34263682693873,1.76762240348778,"IRAK3","interleukin 1 receptor associated kinase 3",TRUE
+"1568830_at",0.843725309945907,0.439064568982421,0.787968116624985,-5.64171097823107,0.21880459171997,"IRAK3","interleukin 1 receptor associated kinase 3",TRUE
+"219618_at",0.923358263835948,0.670852903412853,-0.430692284189336,-5.84973693434066,-0.145049024068993,"IRAK4","interleukin 1 receptor associated kinase 4",TRUE
+"225892_at",0.632949074657601,0.104191553927699,-1.69444959591383,-4.63035492581461,-0.648981115069388,"IREB2","iron responsive element binding protein 2",TRUE
+"214666_x_at",0.687659256779784,0.15662827833275,-1.4662559816013,-4.94351088794787,-0.435919607772481,"IREB2","iron responsive element binding protein 2",TRUE
+"1555476_at",0.767965891104819,0.270746336343046,1.12955110878358,-5.33664842219152,0.68171059080861,"IREB2","iron responsive element binding protein 2",TRUE
+"242261_at",0.904832003218088,0.609705041540452,0.517835820000271,-5.80991284664606,0.238886500678015,"IREB2","iron responsive element binding protein 2",TRUE
+"202531_at",0.415137431205397,0.0168149400378721,2.58571224032794,-3.12128253089784,1.30605096741447,"IRF1","interferon regulatory factor 1",TRUE
+"238725_at",0.733078856183465,0.217583972165437,1.26907594116922,-5.18428372144437,1.11197183376569,"IRF1","interferon regulatory factor 1",TRUE
+"203275_at",0.88113080359582,0.537269789765168,0.626685159549876,-5.75018635691352,0.275345636065493,"IRF2","interferon regulatory factor 2",TRUE
+"213771_at",0.863769633081355,0.489549252400503,-0.702718417973008,-5.70198560965233,-0.207212882731001,"IRF2BP1","interferon regulatory factor 2 binding protein 1",TRUE
+"225854_x_at",0.481363249480408,0.0273106810797194,2.36307237904807,-3.53385393338507,0.60250395003558,"IRF2BP2","interferon regulatory factor 2 binding protein 2",TRUE
+"227389_x_at",0.766550448794594,0.267577363762911,1.13726508630857,-5.32862987700127,0.650539531084626,"IRF2BP2","interferon regulatory factor 2 binding protein 2",TRUE
+"224571_at",0.921716759218618,0.665881237336566,-0.437643491866263,-5.84682351611879,-0.211991491110185,"IRF2BP2","interferon regulatory factor 2 binding protein 2",TRUE
+"224572_s_at",0.948962238903406,0.769737251209521,-0.29633082604138,-5.8970037849853,-0.167376233382964,"IRF2BP2","interferon regulatory factor 2 binding protein 2",TRUE
+"224570_s_at",0.961212424803935,0.824034009403736,-0.225009698212166,-5.91505382654655,-0.0789064037090572,"IRF2BP2","interferon regulatory factor 2 binding protein 2",TRUE
+"224569_s_at",0.96350209729653,0.833451155896146,-0.212770794955103,-5.91765746968959,-0.0926804002815622,"IRF2BP2","interferon regulatory factor 2 binding protein 2",TRUE
+"223474_at",0.482017726238942,0.0274061532431728,-2.36144178030861,-3.53680085074672,-0.783672462417819,"IRF2BPL","interferon regulatory factor 2 binding protein like",TRUE
+"202621_at",0.975398143273847,0.881300058606806,0.151053868287417,-5.92857613616825,0.0548617737876587,"IRF3","interferon regulatory factor 3",TRUE
+"216987_at",0.544577979658206,0.046689772168506,2.10670971189405,-3.98221090000912,1.72639307592288,"IRF4","interferon regulatory factor 4",TRUE
+"204562_at",0.784498961298069,0.307744558242725,1.04399594060371,-5.42232108923174,0.576120719340133,"IRF4","interferon regulatory factor 4",TRUE
+"216986_s_at",0.986342822130003,0.934201722692781,0.0835026400729127,-5.93628791065437,0.0490339621444393,"IRF4","interferon regulatory factor 4",TRUE
+"205469_s_at",0.746535697909741,0.238353265791578,1.21180241266541,-5.2486898375175,0.732888499034805,"IRF5","interferon regulatory factor 5",TRUE
+"205468_s_at",0.949111954119507,0.770434142619697,-0.295406232010986,-5.8972691453758,-0.204910782112314,"IRF5","interferon regulatory factor 5",TRUE
+"239412_at",0.955735662836499,0.797939973585763,0.259113313212035,-5.90703500865203,0.188140298955648,"IRF5","interferon regulatory factor 5",TRUE
+"1552478_a_at",0.736223289546449,0.221674241336028,1.2574764684725,-5.19753402728667,1.31719818247485,"IRF6","interferon regulatory factor 6",TRUE
+"1552477_a_at",0.757479140651,0.25365692209218,1.17197098742686,-5.29196039270367,1.37287907514126,"IRF6","interferon regulatory factor 6",TRUE
+"202597_at",0.839045421044582,0.424840117717388,0.813050311266838,-5.62273915161455,0.745135317237237,"IRF6","interferon regulatory factor 6",TRUE
+"208436_s_at",0.960475119626191,0.820497889574882,0.229614370945211,-5.91403674466044,0.198511102562087,"IRF7","interferon regulatory factor 7",TRUE
+"204057_at",0.8920930097751,0.563288925932056,0.586771073903984,-5.77336464704248,0.35721226077542,"IRF8","interferon regulatory factor 8",TRUE
+"203882_at",0.939452234779565,0.728838048819858,0.351088937397671,-5.8798240871404,0.213111390503085,"IRF9","interferon regulatory factor 9",TRUE
+"214392_at",0.929088231432081,0.687812679609379,-0.407138690488687,-5.85926788322683,-0.337748789300823,"IRGC","immunity related GTPase cinema",TRUE
+"1563335_at",0.842397669245069,0.436243467251476,0.792902230460661,-5.63802305057217,0.456653052065769,"IRGM","immunity related GTPase M",TRUE
+"64488_at",0.250841691547337,0.00355269826110542,-3.26125523169155,-1.77185671324901,-1.36110911959384,"IRGQ","immunity related GTPase Q",TRUE
+"1555833_a_at",0.331700023364203,0.008090440414131,-2.90939089395257,-2.4901400128082,-1.20410687295242,"IRGQ","immunity related GTPase Q",TRUE
+"221877_at",0.374466968080251,0.0113761249927992,-2.7601439552427,-2.78527150458455,-1.33848143191365,"IRGQ","immunity related GTPase Q",TRUE
+"242183_at",0.51470556386048,0.0353545137356942,-2.24118556335248,-3.75088104062895,-1.6237109440011,"IRGQ","immunity related GTPase Q",TRUE
+"239177_at",0.765400039004994,0.265669465746175,-1.14194173914377,-5.32374514825485,-0.337229437075734,"IRGQ","immunity related GTPase Q",TRUE
+"1569310_at",0.867152480894159,0.499038917445537,0.687278161019639,-5.71220073250834,0.224851119589015,"IRGQ","immunity related GTPase Q",TRUE
+"242979_at",0.93924047634328,0.728081007935203,-0.352112361977612,-5.87947563770024,-0.315826696673197,"IRS1","insulin receptor substrate 1",TRUE
+"204686_at",0.980434477155705,0.908586822151421,-0.116141275161579,-5.93311572047345,-0.1097780604872,"IRS1","insulin receptor substrate 1",TRUE
+"238933_at",0.984916798133038,0.925718410711265,-0.0943000473556264,-5.93535320033267,-0.0611286864756391,"IRS1","insulin receptor substrate 1",TRUE
+"209184_s_at",0.257126595624443,0.00378576880617606,3.23443776426785,-1.82753567148445,2.18431002502377,"IRS2","insulin receptor substrate 2",TRUE
+"209185_s_at",0.347515673982638,0.00902656973795812,2.86171051790109,-2.58512952483606,2.73938706685486,"IRS2","insulin receptor substrate 2",TRUE
+"207403_at",0.843753336849204,0.439345686660032,0.787477509859576,-5.64207648998206,0.200320674021177,"IRS4","insulin receptor substrate 4",TRUE
+"1560652_at",0.960511640674753,0.820620388828515,0.229454770259196,-5.91407234027398,0.167754050768873,"IRS4","insulin receptor substrate 4",TRUE
+"230472_at",0.77766827327863,0.296681976811326,1.06876452274466,-5.39813810944271,1.00631033042972,"IRX1","iroquois homeobox 1",TRUE
+"228462_at",0.931370027472813,0.696679367485684,-0.394918189861362,-5.86400510403599,-0.728951271979385,"IRX2","iroquois homeobox 2",TRUE
+"228404_at",0.968451827985008,0.852061820188942,0.188679154199079,-5.92235897955113,0.138375235716302,"IRX2","iroquois homeobox 2",TRUE
+"229638_at",0.724652102844753,0.202173629205192,-1.31434797460389,-5.13157846713901,-1.42761986513689,"IRX3","iroquois homeobox 3",TRUE
+"220225_at",0.908667507590078,0.62020575830497,-0.502598257175275,-5.81739221990199,-0.59262537944683,"IRX4","iroquois homeobox 4",TRUE
+"210239_at",0.043795211728206,5.14728615938535e-05,-5.00152202724204,1.95390567571075,-5.52413607526795,"IRX5","iroquois homeobox 5",TRUE
+"209273_s_at",0.835952408568777,0.416107462321451,0.828708944430948,-5.61061252897505,0.230935256721891,"ISCA1","iron-sulfur cluster assembly 1",TRUE
+"221425_s_at",0.921312278448293,0.664717918733618,0.439273158421115,-5.84613385707683,0.175177564996403,"ISCA1","iron-sulfur cluster assembly 1",TRUE
+"209274_s_at",0.948429371744093,0.765125300519056,-0.302456382787866,-5.895224971649,-0.0855826268574855,"ISCA1","iron-sulfur cluster assembly 1",TRUE
+"226007_at",0.619415519928971,0.0895442236105745,-1.77555939407544,-4.51077778343357,-0.694045736314624,"ISCA2","iron-sulfur cluster assembly 2",TRUE
+"209075_s_at",0.928167838756364,0.68427403187,-0.412033386299424,-5.85733062839756,-0.152460337293476,"ISCU","iron-sulfur cluster assembly enzyme",TRUE
+"205483_s_at",0.497725944448536,0.0305764919220297,2.31006204542811,-3.62906249019642,2.1754985180808,"ISG15","ISG15 ubiquitin-like modifier",TRUE
+"204698_at",0.8920930097751,0.563237069707253,0.586849652992263,-5.77332046313776,0.841348377522584,"ISG20","interferon stimulated exonuclease gene 20",TRUE
+"33304_at",0.957430653957785,0.80740196176013,0.246712807385393,-5.91008071458247,0.157563189191418,"ISG20","interferon stimulated exonuclease gene 20",TRUE
+"216502_at",0.760439386481756,0.259318935046327,1.1576887409275,-5.30716788605484,0.780180301025856,"ISG20L2","interferon stimulated exonuclease gene 20 like 2",TRUE
+"212766_s_at",0.810589895425672,0.354699382373692,-0.945303698661188,-5.51357165828731,-0.359554514118143,"ISG20L2","interferon stimulated exonuclease gene 20 like 2",TRUE
+"208114_s_at",0.915569510513076,0.644135077016393,-0.468313055388448,-5.83342308272537,-0.1698129051024,"ISG20L2","interferon stimulated exonuclease gene 20 like 2",TRUE
+"206104_at",0.643082025527735,0.113387082955219,1.64836308133275,-4.69642243872274,1.98782809873001,"ISL1","ISL LIM homeobox 1",TRUE
+"232352_at",0.768852835478002,0.27395425634666,1.12180939459763,-5.34464731350865,1.56241114975678,"ISL2","ISL LIM homeobox 2",TRUE
+"207191_s_at",0.554383599468784,0.0507737862627754,2.06543673494967,-4.05138920087831,1.57334062919302,"ISLR","immunoglobulin superfamily containing leucine rich repeat",TRUE
+"232208_at",0.805746717966166,0.345253799436993,0.964400525547737,-5.49655848688075,0.60048111491948,"ISLR2","immunoglobulin superfamily containing leucine rich repeat 2",TRUE
+"232888_at",0.722937902375896,0.199530286690456,1.32238061219416,-5.12206360981079,0.583802794595447,"ISM1","isthmin 1, angiogenesis inhibitor",TRUE
+"235182_at",0.863548047008085,0.488451520837166,-0.704515526786025,-5.70078259757488,-0.745800865099443,"ISM1","isthmin 1, angiogenesis inhibitor",TRUE
+"240719_at",0.597879550155311,0.0753282159689445,1.86604860547609,-4.37258243515604,0.903928671802912,"ISM1-AS1","ISM1 antisense RNA 1",TRUE
+"228212_at",0.700511129947842,0.172314935656069,1.4103727101403,-5.01466906720473,0.605486287465575,"ISM2","isthmin 2",TRUE
+"218170_at",0.603702127972549,0.0777021673007425,-1.84995954963051,-4.39751306742064,-1.0327603964383,"ISOC1","isochorismatase domain containing 1",TRUE
+"218893_at",0.689848451630875,0.15900453003592,-1.45750872414748,-4.9547977299384,-0.518023982194844,"ISOC2","isochorismatase domain containing 2",TRUE
+"233594_at",0.899755026004388,0.591417662444442,0.544674837650636,-5.79621006476392,0.346741316100568,"ISPD-AS1","ISPD antisense RNA 1",TRUE
+"1568872_at",0.913123070637484,0.635176413950003,0.481079952479529,-5.82758296861725,0.344812250904097,"ISPD-AS1","ISPD antisense RNA 1",TRUE
+"200851_s_at",0.896229101808264,0.579951011137301,-0.561711108065104,-5.78716315320048,-0.195144107557685,"IST1","IST1, ESCRT-III associated factor",TRUE
+"1562848_at",0.930083070178974,0.691449867731014,-0.402118214679561,-5.86123124846032,-0.276274509203667,"IST1","IST1, ESCRT-III associated factor",TRUE
+"232707_at",0.9704258013307,0.85910416208157,-0.179593291790603,-5.9239860672936,-0.124700690116935,"ISX","intestine specific homeobox",TRUE
+"223428_s_at",0.856340271686102,0.470309751773027,0.73456192803228,-5.68023613159184,0.332730392688726,"ISY1","ISY1 splicing factor homolog",TRUE
+"232142_at",0.88767000285873,0.552475373350775,0.603239092295456,-5.7639799508589,0.351599643178229,"ISY1","ISY1 splicing factor homolog",TRUE
+"223429_x_at",0.961363786439135,0.82460132588269,0.224271414231818,-5.91521499189027,0.0789820023549019,"ISY1","ISY1 splicing factor homolog",TRUE
+"223831_x_at",0.967098812766994,0.846521069432632,-0.195839102073003,-5.92102041698493,-0.053445089174561,"ISY1","ISY1 splicing factor homolog",TRUE
+"225632_s_at",0.886782011834068,0.549881801523786,-0.607213825787084,-5.76167727678988,-0.251353584729646,"ISY1-RAB43///RAB43","ISY1-RAB43 readthrough///RAB43, member RAS oncogene family",TRUE
+"229324_x_at",0.900692252557887,0.595977201354496,0.537945944262606,-5.79970878520543,0.367619683385104,"ISYNA1","inositol-3-phosphate synthase 1",TRUE
+"228417_at",0.929614487334131,0.689817866987351,-0.404369586180054,-5.86035376664083,-0.262264703093859,"ISYNA1","inositol-3-phosphate synthase 1",TRUE
+"228552_s_at",0.959357995170594,0.815912130675884,0.235593450110208,-5.91268549645816,0.109266637714985,"ISYNA1","inositol-3-phosphate synthase 1",TRUE
+"222240_s_at",0.989524702314661,0.948577230964683,0.0652282492791472,-5.93761137377449,0.0602927647992999,"ISYNA1","inositol-3-phosphate synthase 1",TRUE
+"236235_at",0.769847953580141,0.278473765354283,1.11101392643873,-5.35572008223791,0.628220953462762,"ITCH","itchy E3 ubiquitin protein ligase",TRUE
+"209743_s_at",0.780697400209124,0.302440816348047,1.05579033772658,-5.41086900197377,0.585144780653149,"ITCH","itchy E3 ubiquitin protein ligase",TRUE
+"217094_s_at",0.80110325033185,0.337634553538461,0.98006587584284,-5.48237037899846,0.441134066866132,"ITCH","itchy E3 ubiquitin protein ligase",TRUE
+"239101_at",0.857381762624307,0.472839223001975,0.730332414519553,-5.68317769254801,0.471969430178954,"ITCH","itchy E3 ubiquitin protein ligase",TRUE
+"209744_x_at",0.87579870142401,0.52367156832794,0.647956339378894,-5.73723448068634,0.286552150543093,"ITCH","itchy E3 ubiquitin protein ligase",TRUE
+"235057_at",0.975265330414469,0.8805049890968,0.152073807477166,-5.92842571654453,0.119895697218749,"ITCH","itchy E3 ubiquitin protein ligase",TRUE
+"221449_s_at",0.503451707465643,0.0326334312072837,-2.27928322230641,-3.68376810126773,-0.910629300427239,"ITFG1","integrin alpha FG-GAP repeat containing 1",TRUE
+"1556151_at",0.523369751179323,0.0389117153826054,-2.195223779352,-3.83093930211077,-1.0144765840265,"ITFG1","integrin alpha FG-GAP repeat containing 1",TRUE
+"239044_at",0.739189560382301,0.225875524526186,-1.24573154412105,-5.21084416158407,-0.604317900697922,"ITFG1","integrin alpha FG-GAP repeat containing 1",TRUE
+"238775_at",0.794426378358553,0.326224484338831,-1.00398642031333,-5.46030432488422,-0.44886248902957,"ITFG1","integrin alpha FG-GAP repeat containing 1",TRUE
+"227191_at",0.869971289491322,0.507912932956096,-0.672989825488969,-5.72146052139761,-0.477191940764843,"ITFG1","integrin alpha FG-GAP repeat containing 1",TRUE
+"220590_at",0.820286641369748,0.378209527979698,0.89921060211313,-5.55334591469221,0.374790794629472,"ITFG2","integrin alpha FG-GAP repeat containing 2",TRUE
+"1560359_at",0.710672261019989,0.183809024957648,1.37195828195673,-5.06226217669707,1.21215070875799,"ITGA1","integrin subunit alpha 1",TRUE
+"226731_at",0.728385463227073,0.209130310472324,1.29359157733269,-5.15593767523544,0.996931163033103,"ITGA1","integrin subunit alpha 1",TRUE
+"214660_at",0.78065889313777,0.302331466119691,1.05603504859159,-5.41063017010744,0.872099218095522,"ITGA1","integrin subunit alpha 1",TRUE
+"206766_at",0.757924091609327,0.253999874358623,-1.17109920112933,-5.2928933351618,-0.374060714384421,"ITGA10","integrin subunit alpha 10",TRUE
+"233335_at",0.895457620469779,0.574233541922978,-0.570268553099315,-5.78251685428415,-0.355988969412382,"ITGA11","integrin subunit alpha 11",TRUE
+"1554819_a_at",0.901788521024914,0.599189342149182,0.533220578975473,-5.80214048110955,0.249458843489804,"ITGA11","integrin subunit alpha 11",TRUE
+"222899_at",0.986342822130003,0.933289957409503,0.0846626075864842,-5.9361929334554,0.0520793080341297,"ITGA11","integrin subunit alpha 11",TRUE
+"205032_at",0.151185984316021,0.00109500959833826,3.7507921215198,-0.736607481936382,2.69812902526785,"ITGA2","integrin subunit alpha 2",TRUE
+"227314_at",0.393891170804685,0.0134863149839299,2.68466162671893,-2.93193420797528,2.46267976878952,"ITGA2","integrin subunit alpha 2",TRUE
+"206493_at",0.649220725475646,0.119960945987917,1.61731002438225,-4.74015208946523,0.607657568193006,"ITGA2B","integrin subunit alpha 2b",TRUE
+"206494_s_at",0.718706241731185,0.194596060893786,1.33759997342959,-5.10390206415048,1.15843267914776,"ITGA2B","integrin subunit alpha 2b",TRUE
+"216956_s_at",0.760244814241272,0.258505915703934,1.15972524283216,-5.30500944751083,0.461947218980321,"ITGA2B","integrin subunit alpha 2b",TRUE
+"216966_at",0.968035667633768,0.849344614076115,0.192189136156322,-5.92170899003611,0.166447213019821,"ITGA2B","integrin subunit alpha 2b",TRUE
+"201474_s_at",0.425751189365875,0.0181825883938785,2.55031408161573,-3.18816956625307,1.74921968387885,"ITGA3","integrin subunit alpha 3",TRUE
+"205884_at",0.303059342222774,0.00584224136630643,3.04985857992746,-2.20680652312663,3.81644912443725,"ITGA4","integrin subunit alpha 4",TRUE
+"213416_at",0.358427723880268,0.00993883300199563,2.819582470232,-2.66851872866387,3.59663025862712,"ITGA4","integrin subunit alpha 4",TRUE
+"205885_s_at",0.393258278493143,0.0134392553043868,2.68621935717233,-2.92892639258414,3.80904875222241,"ITGA4","integrin subunit alpha 4",TRUE
+"243366_s_at",0.768852835478002,0.274073495114221,1.12152291444597,-5.34494237687936,1.14420008291936,"ITGA4","integrin subunit alpha 4",TRUE
+"201389_at",0.499983604958508,0.0316867402889033,2.29322136107101,-3.65904788118779,1.62244713318715,"ITGA5","integrin subunit alpha 5",TRUE
+"201656_at",0.497725944448536,0.0306630386328463,2.30872928830311,-3.63144015403986,2.4321826768022,"ITGA6","integrin subunit alpha 6",TRUE
+"215177_s_at",0.522403182336918,0.038187800465268,2.20425854875943,-3.81528187867019,2.95483876429869,"ITGA6","integrin subunit alpha 6",TRUE
+"216331_at",0.621591875129701,0.0919575641448847,-1.76144890671306,-4.53187726431475,-1.06203846367014,"ITGA7","integrin subunit alpha 7",TRUE
+"209663_s_at",0.841088238127348,0.430856588953158,-0.80237883953766,-5.63087918058325,-0.631718031096386,"ITGA7","integrin subunit alpha 7",TRUE
+"242071_x_at",0.789795896476304,0.318511648235425,1.02048670278962,-5.44480217247795,0.311782497907074,"ITGA8","integrin subunit alpha 8",TRUE
+"235666_at",0.92260505525875,0.669029875319111,0.433238655702852,-5.84867500529738,0.24910676615213,"ITGA8","integrin subunit alpha 8",TRUE
+"239092_at",0.945819521856653,0.755224491062255,0.315646904892349,-5.89127210557156,0.138596321131629,"ITGA8","integrin subunit alpha 8",TRUE
+"214265_at",0.998218866709129,0.991659625225068,-0.0105718874634107,-5.93962904438014,-0.00483238690773824,"ITGA8","integrin subunit alpha 8",TRUE
+"1555335_at",0.757950630724418,0.254541997562192,1.16972290547624,-5.29436494182857,0.867592028481007,"ITGA9","integrin subunit alpha 9",TRUE
+"227297_at",0.808328926947236,0.351312117605045,-0.952111884978677,-5.50754204924731,-1.28802001296639,"ITGA9","integrin subunit alpha 9",TRUE
+"206009_at",0.969882914559333,0.857323638278888,-0.181888989561787,-5.92358251147281,-0.107163038500809,"ITGA9","integrin subunit alpha 9",TRUE
+"1555336_a_at",0.991059530537351,0.958210560910045,-0.0529953132958214,-5.93831565495091,-0.0418160563537242,"ITGA9","integrin subunit alpha 9",TRUE
+"1563635_at",0.345823377376834,0.00883323972329112,2.87115782907154,-2.56635905903004,1.96271522685224,"ITGA9-AS1","ITGA9 antisense RNA 1",TRUE
+"1560686_at",0.983783029912313,0.920891320744566,0.100448927406445,-5.93477021474209,0.0545989572029741,"ITGAD","integrin subunit alpha D",TRUE
+"205055_at",0.934081042629428,0.708329410617853,0.378953730360498,-5.86997935066628,0.121162625531532,"ITGAE","integrin subunit alpha E",TRUE
+"1554240_a_at",0.54295328972902,0.0461920958016641,-2.11195883035426,-3.97334979279963,-1.65158613908291,"ITGAL","integrin subunit alpha L",TRUE
+"213475_s_at",0.994701128358967,0.975459985054903,0.0311104680814335,-5.93921208222657,0.0176604404290339,"ITGAL","integrin subunit alpha L",TRUE
+"205786_s_at",0.325561979764819,0.007455026953188,2.94485972974206,-2.41907513044498,1.73889255000898,"ITGAM","integrin subunit alpha M",TRUE
+"205785_at",0.955959857580254,0.801055289974311,0.255026013955364,-5.90805529256455,0.0917885293789809,"ITGAM","integrin subunit alpha M",TRUE
+"202351_at",0.752312913127213,0.245646918187411,1.19258711184483,-5.26972142908505,0.550188761130359,"ITGAV","integrin subunit alpha V",TRUE
+"1563003_at",0.919406408954167,0.657634126042608,-0.449223020753627,-5.841868617745,-0.211585560260407,"ITGAX","integrin subunit alpha X",TRUE
+"210184_at",0.996145862517277,0.980805125137495,0.0243326037346268,-5.93939510666636,0.0142151524317828,"ITGAX","integrin subunit alpha X",TRUE
+"1553678_a_at",0.260111283269276,0.00385825790089405,3.22642309192484,-1.84414957690223,1.40910471417424,"ITGB1","integrin subunit beta 1",TRUE
+"1553530_a_at",0.308621629697291,0.00631585196371455,3.01639512736513,-2.27475343417948,1.32576110388465,"ITGB1","integrin subunit beta 1",TRUE
+"211945_s_at",0.517654151778308,0.0368225419738771,2.22172937603041,-3.78489346184085,0.660381349401638,"ITGB1","integrin subunit beta 1",TRUE
+"215878_at",0.653206225743412,0.122588377567037,1.60529657217667,-4.75689741336415,1.48448400384458,"ITGB1","integrin subunit beta 1",TRUE
+"216190_x_at",0.838350471423215,0.423373831513977,0.815665335443571,-5.62072906037746,0.603372987067003,"ITGB1","integrin subunit beta 1",TRUE
+"215879_at",0.840872144163754,0.430298703714531,0.803364453661153,-5.63013160310392,0.609902601385858,"ITGB1","integrin subunit beta 1",TRUE
+"216178_x_at",0.861659105448003,0.482832970955523,0.713750438063766,-5.69455444033067,0.443455547550608,"ITGB1","integrin subunit beta 1",TRUE
+"203336_s_at",0.723655063748891,0.200483234216199,1.31947526384008,-5.12551071342401,0.480611658264877,"ITGB1BP1","integrin subunit beta 1 binding protein 1",TRUE
+"203337_x_at",0.77547560202111,0.29259075578816,-1.07809144578331,-5.38890013065388,-0.587803527211754,"ITGB1BP1","integrin subunit beta 1 binding protein 1",TRUE
+"228227_at",0.883190352125328,0.541030429209741,-0.620853973039264,-5.75366426462019,-0.321548052952426,"ITGB1BP1","integrin subunit beta 1 binding protein 1",TRUE
+"219829_at",0.971216837324271,0.861745036106836,0.17619012568581,-5.92457490019326,0.121536962016809,"ITGB1BP2","integrin subunit beta 1 binding protein 2",TRUE
+"236988_x_at",0.525405708458677,0.0393395340492715,2.18995587438353,-3.84005046870312,0.843055956946213,"ITGB2","integrin subunit beta 2",TRUE
+"1555349_a_at",0.559434208511607,0.053909468255923,2.03571855580207,-4.10064768395821,2.27715566670294,"ITGB2","integrin subunit beta 2",TRUE
+"202803_s_at",0.635821858586292,0.106747982305743,1.68130255026915,-4.64934267711211,1.74835544692069,"ITGB2","integrin subunit beta 2",TRUE
+"229041_s_at",0.826140850652187,0.394006717971391,0.869292640005559,-5.5781782197281,0.945597876387757,"ITGB2-AS1","ITGB2 antisense RNA 1",TRUE
+"229040_at",0.978928101156583,0.897170207228195,-0.130727954150778,-5.9313630966836,-0.119190160226438,"ITGB2-AS1","ITGB2 antisense RNA 1",TRUE
+"211579_at",0.756006545489432,0.250861762097637,1.17910922651015,-5.28429857356904,0.562914495064311,"ITGB3","integrin subunit beta 3",TRUE
+"204626_s_at",0.758436363256407,0.255501691727093,1.1672918502974,-5.29696065054495,0.76171629360122,"ITGB3","integrin subunit beta 3",TRUE
+"215240_at",0.761748280722165,0.261049118070101,-1.15337054644746,-5.31173361504592,-1.01113654499858,"ITGB3","integrin subunit beta 3",TRUE
+"216261_at",0.835952408568777,0.417025863497175,0.827052486031313,-5.61190559636035,0.323039644161689,"ITGB3","integrin subunit beta 3",TRUE
+"204628_s_at",0.839425347843955,0.425289761412959,0.812249531497783,-5.62335347633165,0.422422786917049,"ITGB3","integrin subunit beta 3",TRUE
+"204625_s_at",0.877074739399942,0.52625676547718,-0.643889488889082,-5.73974288207237,-0.502465305118914,"ITGB3","integrin subunit beta 3",TRUE
+"204627_s_at",0.907576524801672,0.616789703378608,0.507541891632248,-5.81498950639538,0.574014621832502,"ITGB3","integrin subunit beta 3",TRUE
+"205176_s_at",0.794620886196317,0.326756877909546,1.00285752115819,-5.46135656586376,0.351255801804637,"ITGB3BP","integrin subunit beta 3 binding protein",TRUE
+"211905_s_at",0.0550194051692779,8.99876001512888e-05,4.7722722824115,1.46456806717055,2.91739515998409,"ITGB4","integrin subunit beta 4",TRUE
+"214292_at",0.0595361125571683,0.00012888166435056,4.62535425558922,1.14910796287906,2.75067038122224,"ITGB4","integrin subunit beta 4",TRUE
+"204990_s_at",0.170374697680568,0.00142490221991052,3.64221292285553,-0.968709325023625,3.71067160920613,"ITGB4","integrin subunit beta 4",TRUE
+"204989_s_at",0.209119042035931,0.00241816877051698,3.42262564157246,-1.43418480869608,3.72888188474085,"ITGB4","integrin subunit beta 4",TRUE
+"230704_s_at",0.812302873476553,0.360173404144009,0.93439334935021,-5.52315151260267,0.540760385571902,"ITGB4","integrin subunit beta 4",TRUE
+"201124_at",0.774230543658252,0.288716548776779,-1.08701031118823,-5.37999928637194,-0.691069226174974,"ITGB5","integrin subunit beta 5",TRUE
+"201125_s_at",0.89390639630277,0.569563741167553,-0.577289959421963,-5.77865371689619,-0.345800575891587,"ITGB5","integrin subunit beta 5",TRUE
+"214021_x_at",0.921006039723366,0.663859193827944,-0.440476902278212,-5.84562282880762,-0.303258441114554,"ITGB5","integrin subunit beta 5",TRUE
+"214020_x_at",0.957017346544368,0.805306572093485,0.249455465923311,-5.90941987002878,0.0881702201314507,"ITGB5","integrin subunit beta 5",TRUE
+"205718_at",0.954506242294505,0.791541283890514,-0.267522653881803,-5.90488515898687,-0.16090423715857,"ITGB7","integrin subunit beta 7",TRUE
+"226189_at",0.536422380101288,0.04327055598606,2.14384087149112,-3.91922894080613,3.66782166033923,"ITGB8","integrin subunit beta 8",TRUE
+"205816_at",0.571677937624457,0.0596929007022958,1.98473327729254,-4.18405220052764,2.47212210069807,"ITGB8","integrin subunit beta 8",TRUE
+"242982_x_at",0.592111379991983,0.069193173339049,1.90977660232458,-4.30405759996024,1.69671097423295,"ITGB8","integrin subunit beta 8",TRUE
+"1563010_at",0.726636642789909,0.206300136029983,1.30197020941266,-5.14614425695618,1.16388947138341,"ITGB8","integrin subunit beta 8",TRUE
+"211488_s_at",0.744307803443383,0.235278861763365,1.22003490315244,-5.23959001262927,0.708386524470905,"ITGB8","integrin subunit beta 8",TRUE
+"205422_s_at",0.231131606308726,0.00293852838076065,3.34107248495894,-1.60537441088112,5.61700418512633,"ITGBL1","integrin subunit beta like 1",TRUE
+"231993_at",0.423421354964585,0.0177901815539333,2.5602083589741,-3.1695203776039,2.98013496255477,"ITGBL1","integrin subunit beta like 1",TRUE
+"1557080_s_at",0.48580305784244,0.0283952297781937,2.3448501555884,-3.56672074784814,3.15749346620888,"ITGBL1","integrin subunit beta like 1",TRUE
+"214927_at",0.557589172116298,0.0525164022383692,2.0487253014591,-4.079146349074,1.79234842414705,"ITGBL1","integrin subunit beta like 1",TRUE
+"1557079_at",0.682504456039784,0.150007970007696,1.49120714245428,-4.91101596351169,1.88572077263507,"ITGBL1","integrin subunit beta like 1",TRUE
+"210888_s_at",0.92070400963176,0.662603774503713,-0.442237916038947,-5.84487274882949,-0.221980678555843,"ITIH1","inter-alpha-trypsin inhibitor heavy chain 1",TRUE
+"204987_at",0.843475287501313,0.438311158619224,0.789283920869277,-5.64072961964533,0.39190380161167,"ITIH2","inter-alpha-trypsin inhibitor heavy chain 2",TRUE
+"205755_at",0.932830928398943,0.703345021069672,0.385771498800132,-5.86745771833103,0.287205599100803,"ITIH3","inter-alpha-trypsin inhibitor heavy chain 3",TRUE
+"37201_at",0.730101539866086,0.21294795164599,1.28242751164635,-5.16890334670478,0.725847214411208,"ITIH4","inter-alpha-trypsin inhibitor heavy chain family member 4",TRUE
+"242720_at",0.798471513722685,0.332999496221393,-0.989714650814108,-5.47352785285417,-0.661728928561802,"ITIH4","inter-alpha-trypsin inhibitor heavy chain family member 4",TRUE
+"241167_at",0.824677780506192,0.392134850253315,0.872796450565451,-5.57531031751409,0.414785639906301,"ITIH4","inter-alpha-trypsin inhibitor heavy chain family member 4",TRUE
+"206287_s_at",0.991059530537351,0.958340487950392,0.0528303856659886,-5.93832415480001,0.0157902816823485,"ITIH4","inter-alpha-trypsin inhibitor heavy chain family member 4",TRUE
+"219064_at",0.861962516141708,0.484517744259853,0.710974767041167,-5.6964345126757,0.370182027583529,"ITIH5","inter-alpha-trypsin inhibitor heavy chain family member 5",TRUE
+"1553243_at",0.963120895816356,0.832298110415616,0.214267516470501,-5.91734684234766,0.124829155076248,"ITIH5","inter-alpha-trypsin inhibitor heavy chain family member 5",TRUE
+"234894_at",0.948989397056643,0.769909859134864,0.296101795583824,-5.89706959381373,0.192363653668825,"ITIH6","inter-alpha-trypsin inhibitor heavy chain family member 6",TRUE
+"211339_s_at",0.991059530537351,0.958342443064275,0.052827903882318,-5.93832428250103,0.0135344538177948,"ITK","IL2 inducible T-cell kinase",TRUE
+"223597_at",0.985361089461736,0.927506090605442,-0.0920238092493997,-5.93555968591812,-0.0317759874592305,"ITLN1","intelectin 1",TRUE
+"202747_s_at",0.806547872024039,0.347490474136228,-0.959846737860211,-5.5006436781826,-0.9638729179162,"ITM2A","integral membrane protein 2A",TRUE
+"202746_at",0.854184492233394,0.464028617065058,-0.745123084715866,-5.67282066240537,-1.10410402554455,"ITM2A","integral membrane protein 2A",TRUE
+"217731_s_at",0.317600554649094,0.00691106725696612,-2.97760378205235,-2.35317563476723,-3.14511932310047,"ITM2B","integral membrane protein 2B",TRUE
+"217732_s_at",0.358427723880268,0.0098567144947208,-2.82322054257,-2.66133794150048,-1.69666351341501,"ITM2B","integral membrane protein 2B",TRUE
+"221004_s_at",0.726696341943087,0.206957270057537,1.30001688044246,-5.1484322121398,1.41395638014641,"ITM2C","integral membrane protein 2C",TRUE
+"209171_at",0.983777183253528,0.920583652416856,0.100840975751169,-5.93473179673068,0.0870422085525728,"ITPA","inosine triphosphatase",TRUE
+"210740_s_at",0.672434875127089,0.138341110287007,-1.53745500715697,-4.84962506822096,-0.711361652747511,"ITPK1","inositol-tetrakisphosphate 1-kinase",TRUE
+"217710_x_at",0.806221445484273,0.347024119360973,-0.960794569594748,-5.49979483753182,-0.545207839992028,"ITPK1","inositol-tetrakisphosphate 1-kinase",TRUE
+"210197_at",0.902307786832759,0.601186329684281,0.530289008129067,-5.80363858962811,0.158118209292249,"ITPK1","inositol-tetrakisphosphate 1-kinase",TRUE
+"1563524_a_at",0.896292432634083,0.580310852379526,0.561173948529033,-5.78745253369563,0.423438187624734,"ITPK1-AS1","ITPK1 antisense RNA 1",TRUE
+"234594_at",0.997275650300134,0.986130969507572,-0.0175803692993279,-5.93953294556827,-0.00578345319101548,"ITPK1-AS1","ITPK1 antisense RNA 1",TRUE
+"205874_at",0.982243328340126,0.914784757478731,-0.108233355158579,-5.93397940981326,-0.0625513128883508,"ITPKA","inositol-trisphosphate 3-kinase A",TRUE
+"235213_at",0.837368340567858,0.421175674173272,-0.819596241254114,-5.61769610598345,-0.69084721025728,"ITPKB","inositol-trisphosphate 3-kinase B",TRUE
+"203723_at",0.902521078772712,0.601597405111267,-0.529686134940288,-5.80394567701272,-0.550915801936669,"ITPKB","inositol-trisphosphate 3-kinase B",TRUE
+"232526_at",0.95442332217412,0.790375378073448,-0.269057027462003,-5.90448553995985,-0.163907293124526,"ITPKB","inositol-trisphosphate 3-kinase B",TRUE
+"1554306_at",0.969882914559333,0.857052424105197,0.182238763918724,-5.92352057683066,0.174483770043339,"ITPKB","inositol-trisphosphate 3-kinase B",TRUE
+"232499_at",0.992652985145734,0.965583106757947,0.0436389422729408,-5.93875598109557,0.0307437400239952,"ITPKB","inositol-trisphosphate 3-kinase B",TRUE
+"240398_at",0.922635094827638,0.669179006309806,0.433030243185155,-5.84876215185917,0.162512876264143,"ITPKB-IT1","ITPKB intronic transcript 1",TRUE
+"213076_at",0.570595961640471,0.0590268085786649,-1.99037595201296,-4.17489131530455,-0.765637999697201,"ITPKC","inositol-trisphosphate 3-kinase C",TRUE
+"1562373_at",0.713633547141264,0.188567791353114,-1.35661023777924,-5.08097199200264,-1.43427491441778,"ITPR1","inositol 1,4,5-trisphosphate receptor type 1",TRUE
+"240052_at",0.78885145722244,0.315161886156454,1.0277399940245,-5.43791536705497,0.740443530708322,"ITPR1","inositol 1,4,5-trisphosphate receptor type 1",TRUE
+"203710_at",0.854343866520736,0.465119332983196,-0.74328308702149,-5.67411982880258,-0.793817642884375,"ITPR1","inositol 1,4,5-trisphosphate receptor type 1",TRUE
+"211323_s_at",0.90466378569832,0.609017009044489,-0.518838530502002,-5.80941302973032,-0.570564485787592,"ITPR1","inositol 1,4,5-trisphosphate receptor type 1",TRUE
+"216944_s_at",0.974982245454858,0.878392597510407,-0.154784452831191,-5.92802104448614,-0.1830174362414,"ITPR1","inositol 1,4,5-trisphosphate receptor type 1",TRUE
+"239764_at",0.683108395823428,0.152228375997197,-1.48274064875711,-4.92209179857001,-1.53530583773767,"ITPR1-AS1","ITPR1 antisense RNA 1 (head to head)",TRUE
+"202660_at",0.91238586368984,0.63291905201312,0.484309645753461,-5.82608122473051,0.32143661193953,"ITPR2","inositol 1,4,5-trisphosphate receptor type 2",TRUE
+"202661_at",0.955561357825402,0.796425030446192,0.261102547433558,-5.90653261914946,0.304744119934118,"ITPR2","inositol 1,4,5-trisphosphate receptor type 2",TRUE
+"211360_s_at",0.956240552538229,0.801790432383404,0.25406215586258,-5.90829354477328,0.156986681826528,"ITPR2","inositol 1,4,5-trisphosphate receptor type 2",TRUE
+"202662_s_at",0.972644208712919,0.867653854688815,-0.168583361522455,-5.92585044905885,-0.11333453020271,"ITPR2","inositol 1,4,5-trisphosphate receptor type 2",TRUE
+"201188_s_at",0.451974019443452,0.0217245125395042,2.46906378907423,-3.33990134667388,1.12603265673696,"ITPR3","inositol 1,4,5-trisphosphate receptor type 3",TRUE
+"201189_s_at",0.536422380101288,0.0431483652022286,2.14521616253703,-3.91688282638149,0.978295472320832,"ITPR3","inositol 1,4,5-trisphosphate receptor type 3",TRUE
+"201187_s_at",0.774011928861764,0.285801344721071,1.09377843388231,-5.37320121886273,0.420997431659904,"ITPR3","inositol 1,4,5-trisphosphate receptor type 3",TRUE
+"239542_at",0.998347572104896,0.992745115953287,0.00919592421108777,-5.93964229232865,0.00679392676042578,"ITPR3","inositol 1,4,5-trisphosphate receptor type 3",TRUE
+"225582_at",0.593339168375633,0.0703834703261929,1.90103426779756,-4.31784625131896,1.03806960693593,"ITPRIP","inositol 1,4,5-trisphosphate receptor interacting protein",TRUE
+"244025_at",0.883952384679702,0.542476928249268,0.61861682811257,-5.75499025637362,0.472580849127175,"ITPRIP","inositol 1,4,5-trisphosphate receptor interacting protein",TRUE
+"240037_at",0.525020012390103,0.039155684677029,2.19221328677655,-3.83614778159612,0.73963640514939,"ITPRIPL1","inositol 1,4,5-trisphosphate receptor interacting protein-like 1",TRUE
+"227954_at",0.746172020724,0.23763019395072,1.21373137433235,-5.24656243672128,1.15809960722019,"ITPRIPL2","inositol 1,4,5-trisphosphate receptor interacting protein like 2",TRUE
+"1568619_s_at",0.780095745457321,0.301454898815128,1.05799896482979,-5.40871163704046,1.0522016160255,"ITPRIPL2","inositol 1,4,5-trisphosphate receptor interacting protein like 2",TRUE
+"227792_at",0.838616623280672,0.423790496919672,0.814921665274221,-5.62130131342731,0.81096630023402,"ITPRIPL2","inositol 1,4,5-trisphosphate receptor interacting protein like 2",TRUE
+"227514_at",0.864894115958506,0.493725886408258,0.69590188490387,-5.70652206210177,0.615682779942295,"ITPRIPL2","inositol 1,4,5-trisphosphate receptor interacting protein like 2",TRUE
+"228074_at",0.925447069825085,0.67695451177277,-0.422190571338824,-5.85323790662471,-0.246398166800146,"ITPRIPL2","inositol 1,4,5-trisphosphate receptor interacting protein like 2",TRUE
+"227956_at",0.993615552413264,0.970139709342332,0.0378582864233847,-5.93898542170103,0.01720187063514,"ITPRIPL2","inositol 1,4,5-trisphosphate receptor interacting protein like 2",TRUE
+"1557279_at",0.594005743610726,0.0709888456533159,1.89663760185549,-4.32476411675932,0.627741673677104,"ITSN1","intersectin 1",TRUE
+"230042_at",0.657571067962164,0.126356962588439,1.58843519372189,-4.78023650674504,0.863767893841302,"ITSN1","intersectin 1",TRUE
+"207322_at",0.804658857755908,0.343718475041413,0.967538035597286,-5.49373355552396,0.644963073526195,"ITSN1","intersectin 1",TRUE
+"35776_at",0.809411730389276,0.352559044210717,0.94960050104367,-5.50977084932293,0.360849654570936,"ITSN1","intersectin 1",TRUE
+"209297_at",0.854184492233394,0.464010602772006,0.745153495751504,-5.67279916452432,0.541150914155958,"ITSN1","intersectin 1",TRUE
+"209298_s_at",0.854184492233394,0.464429837667642,0.744445941526764,-5.67329912665598,0.408905349497122,"ITSN1","intersectin 1",TRUE
+"1557280_s_at",0.865885012497452,0.496363333654434,0.691614396126755,-5.70935379866584,0.62462556300035,"ITSN1","intersectin 1",TRUE
+"210713_at",0.946173756317853,0.756108344966431,-0.314467084917826,-5.89163247396176,-0.193665504612913,"ITSN1","intersectin 1",TRUE
+"209898_x_at",0.822850703882235,0.388351987042442,0.879910574967002,-5.5694543878239,0.287713116210879,"ITSN2","intersectin 2",TRUE
+"210545_at",0.864726282448413,0.492149453330858,0.698470823487893,-5.70481736741043,0.380921324011973,"ITSN2","intersectin 2",TRUE
+"209907_s_at",0.878110025868144,0.529979538661187,-0.638052195340958,-5.74331675371609,-0.20011479868846,"ITSN2","intersectin 2",TRUE
+"203682_s_at",0.934643063207672,0.709982444081577,0.376696720095686,-5.8708043632167,0.224317482445297,"IVD","isovaleryl-CoA dehydrogenase",TRUE
+"225311_at",0.956734254923335,0.803595066290308,0.251697109303895,-5.90887435195985,0.165404230803384,"IVD","isovaleryl-CoA dehydrogenase",TRUE
+"203681_at",0.991367768700244,0.959936442856453,0.0508046231358007,-5.93842639555666,0.0230273874208242,"IVD","isovaleryl-CoA dehydrogenase",TRUE
+"216958_s_at",0.993225426079816,0.968216676447459,0.0402977362710107,-5.93889256620721,0.0270363614742202,"IVD","isovaleryl-CoA dehydrogenase",TRUE
+"214599_at",0.865854896594418,0.496029977969218,0.69215558688171,-5.70899728237761,0.656618461380879,"IVL","involucrin",TRUE
+"201362_at",0.795428381027683,0.327568202668343,1.00113962318158,-5.46295574911367,0.425725219590479,"IVNS1ABP","influenza virus NS1A binding protein",TRUE
+"206245_s_at",0.820288124919738,0.378411172830025,0.898823606813271,-5.55367209213501,0.419076622368779,"IVNS1ABP","influenza virus NS1A binding protein",TRUE
+"244235_at",0.844472871821284,0.44125441217822,0.784151481405483,-5.64454879232337,0.4322569536588,"IVNS1ABP","influenza virus NS1A binding protein",TRUE
+"201363_s_at",0.942303845415102,0.740737880237051,0.335051170440276,-5.88515354530479,0.140996238326055,"IVNS1ABP","influenza virus NS1A binding protein",TRUE
+"1562110_at",0.92546912174812,0.67703546285654,0.422077991428481,-5.8532838064118,0.19871368720079,"IWS1","IWS1, SUPT6H interacting protein",TRUE
+"224775_at",0.933181592626315,0.704575570648504,-0.384086604509023,-5.86808502037749,-0.132459825767151,"IWS1","IWS1, SUPT6H interacting protein",TRUE
+"224768_at",0.980001024522674,0.905090541134089,-0.120605481479897,-5.93260129765852,-0.0288857875733104,"IWS1","IWS1, SUPT6H interacting protein",TRUE
+"231070_at",0.975816140197754,0.884383015621017,0.14710049860688,-5.92914963004964,0.177529724391723,"IYD","iodotyrosine deiodinase",TRUE
+"1554196_at",0.998347572104896,0.992636022879261,-0.0093342092422322,-5.93964104426373,-0.00597537095400424,"IZUMO1","izumo sperm-egg fusion 1",TRUE
+"240559_at",0.592111379991983,0.0692989611347663,1.90899430737063,-4.30529325079376,1.11612327855999,"IZUMO2","IZUMO family member 2",TRUE
+"214296_x_at",0.890816525789205,0.559660210851797,0.59227880672185,-5.7702538738288,0.295284387436334,"IZUMO4","IZUMO family member 4",TRUE
+"215734_at",0.953972289986167,0.787725169799809,-0.272547258552158,-5.9035680764841,-0.134914135719129,"IZUMO4","IZUMO family member 4",TRUE
+"235024_at",0.697699759202153,0.168485095431896,-1.42362656686905,-4.99799710476432,-0.614988675099243,"JADE1","jade family PHD finger 1",TRUE
+"225816_at",0.837368340567858,0.420951627965461,-0.819997618464287,-5.61738564796364,-0.35631037348795,"JADE1","jade family PHD finger 1",TRUE
+"218517_at",0.957430653957785,0.807660022471537,-0.246375165520535,-5.91016156741274,-0.101375854542798,"JADE1","jade family PHD finger 1",TRUE
+"225820_at",0.994701128358967,0.975343883790422,0.0312577048069998,-5.93920760979121,0.0133973056720889,"JADE1","jade family PHD finger 1",TRUE
+"212660_at",0.88020017258149,0.535540867657702,0.629373346711282,-5.74857249394941,0.359424604225589,"JADE2","jade family PHD finger 2",TRUE
+"208202_s_at",0.88113080359582,0.537546716552595,0.626255016598159,-5.75044397760224,0.501286007540602,"JADE2","jade family PHD finger 2",TRUE
+"232279_at",0.892856334334787,0.566333016455975,0.582164789750007,-5.77594469183959,0.567112268543805,"JADE2","jade family PHD finger 2",TRUE
+"204866_at",0.757361197594703,0.253275667201345,-1.17294116920583,-5.29092143825842,-0.505245774224981,"JADE3","jade family PHD finger 3",TRUE
+"229924_s_at",0.493750795916809,0.0299546664847929,2.31974077700411,-3.61177163984634,0.838639162357667,"JAG1","jagged 1",TRUE
+"209099_x_at",0.55937703282623,0.0533316618111815,2.04107657778194,-4.09180130086327,2.45495665572271,"JAG1","jagged 1",TRUE
+"216268_s_at",0.566623884595032,0.057051019381722,2.00745226091684,-4.14706162753874,2.56074265688063,"JAG1","jagged 1",TRUE
+"209098_s_at",0.622434989367596,0.0929057774160087,1.75599173574797,-4.54000420978834,1.9017514621703,"JAG1","jagged 1",TRUE
+"231183_s_at",0.628076638668209,0.0994683452085489,1.71947785917851,-4.59390064552323,1.9957558624003,"JAG1","jagged 1",TRUE
+"209097_s_at",0.822744028388039,0.387784428194966,-0.880981819013804,-5.56856878129708,-0.749178713657108,"JAG1","jagged 1",TRUE
+"32137_at",0.912252515563073,0.632577064302168,0.484799395717915,-5.82585264284788,0.336019499330204,"JAG2","jagged 2",TRUE
+"209784_s_at",0.991367768700244,0.959937170710271,0.0508036993135732,-5.93842644127063,0.0477272592144491,"JAG2","jagged 2",TRUE
+"223104_at",0.904381089098038,0.607514011925616,0.52103081397843,-5.80831697012369,0.171016143448252,"JAGN1","jagunal homolog 1",TRUE
+"239695_at",0.892746695408886,0.565383029766875,0.583600930123915,-5.77514240016144,0.523455100634724,"JAK1","Janus kinase 1",TRUE
+"240613_at",0.899808883319249,0.592087651633922,-0.543684490330314,-5.79672765360393,-0.367585297735482,"JAK1","Janus kinase 1",TRUE
+"1552611_a_at",0.91539387234353,0.643293748619195,0.469508635748177,-5.83288269804587,0.271808661980948,"JAK1","Janus kinase 1",TRUE
+"1552610_a_at",0.946941640414848,0.759216628667033,0.310321567997403,-5.89288809444994,0.208934948925444,"JAK1","Janus kinase 1",TRUE
+"201648_at",0.951810226174863,0.778994108405642,0.284070525073172,-5.90045565390497,0.212216114305427,"JAK1","Janus kinase 1",TRUE
+"205842_s_at",0.808257777979515,0.350835412546887,-0.953073591753061,-5.50668712724215,-0.510819211621955,"JAK2","Janus kinase 2",TRUE
+"1562031_at",0.817815704063733,0.370387458621423,0.914328975955169,-5.54050198156768,0.75308922357125,"JAK2","Janus kinase 2",TRUE
+"205841_at",0.892327842300455,0.564589184932003,-0.584801974220927,-5.77446997501723,-0.634623151148104,"JAK2","Janus kinase 2",TRUE
+"211109_at",0.786851686785014,0.312713065655899,1.03307678140555,-5.43282012379937,0.642861584753289,"JAK3","Janus kinase 3",TRUE
+"227677_at",0.83633038614858,0.417885728723532,0.82550368771883,-5.61311243134306,0.584873513855798,"JAK3","Janus kinase 3",TRUE
+"207187_at",0.912041701968169,0.631481493730352,-0.486369139022426,-5.8251184717682,-0.1657051757868,"JAK3","Janus kinase 3",TRUE
+"211108_s_at",0.971469873887034,0.864195550121986,0.173034171963761,-5.92511092201746,0.0859641138496814,"JAK3","Janus kinase 3",TRUE
+"238600_at",0.986455005400648,0.937235997540877,-0.0796432060361909,-5.93659449187729,-0.0734519222324188,"JAKMIP1","janus kinase and microtubule interacting protein 1",TRUE
+"205888_s_at",0.425744368467229,0.0181043558607464,2.55227061592588,-3.18448469832775,1.91466195941028,"JAKMIP2","janus kinase and microtubule interacting protein 2",TRUE
+"205889_s_at",0.769258076576208,0.275624103767132,1.11780571782595,-5.34876489570674,0.949353026286151,"JAKMIP2","janus kinase and microtubule interacting protein 2",TRUE
+"1561101_at",0.978993663119358,0.898221090383529,0.129384105890885,-5.93153321145628,0.0721406380526362,"JAKMIP2-AS1","JAKMIP2 antisense RNA 1",TRUE
+"233076_at",0.948524075167453,0.765880061205625,-0.301453113135435,-5.89551878390136,-0.338538354806049,"JAKMIP3","Janus kinase and microtubule interacting protein 3",TRUE
+"219213_at",0.81727813269668,0.369682425580046,0.915702001441939,-5.53932572982294,0.820454169920973,"JAM2","junctional adhesion molecule 2",TRUE
+"229127_at",0.932091525948902,0.700604934884326,-0.389527378984488,-5.86604962815201,-0.363866138132898,"JAM2","junctional adhesion molecule 2",TRUE
+"212813_at",0.697699759202153,0.168432668656354,1.42380966671585,-4.99776588799565,0.971086663912284,"JAM3","junctional adhesion molecule 3",TRUE
+"231720_s_at",0.961690794738111,0.826411619785353,-0.221916416892204,-5.91572555876363,-0.167780510960867,"JAM3","junctional adhesion molecule 3",TRUE
+"231721_at",0.968035667633768,0.849255227945607,-0.192304643445101,-5.92168739713854,-0.189699888758225,"JAM3","junctional adhesion molecule 3",TRUE
+"228094_at",0.932018790587499,0.699470087502091,-0.391084601343933,-5.86546187833435,-0.173261033476571,"JAML","junction adhesion molecule like",TRUE
+"203298_s_at",0.640987277293074,0.111523455038182,1.65744141563151,-4.68351777236176,0.763761095761428,"JARID2","jumonji and AT-rich interaction domain containing 2",TRUE
+"240674_at",0.730101539866086,0.212901519374812,1.2825623629039,-5.16874730448661,0.969952944982702,"JARID2","jumonji and AT-rich interaction domain containing 2",TRUE
+"203297_s_at",0.774230543658252,0.287164068840366,1.09060847903184,-5.37638987884299,0.483121955858071,"JARID2","jumonji and AT-rich interaction domain containing 2",TRUE
+"240828_at",0.980459547037842,0.908844242392309,-0.115812686271715,-5.9331528191526,-0.0830091502298549,"JARID2-AS1","JARID2 antisense RNA 1",TRUE
+"225800_at",0.635916735157933,0.107004548036254,1.67999787781563,-4.65122086654749,1.92920352962393,"JAZF1","JAZF zinc finger 1",TRUE
+"225798_at",0.734042693548791,0.21840433244,1.26673617288982,-5.18696486516111,0.843755145868549,"JAZF1","JAZF zinc finger 1",TRUE
+"1559650_at",0.823518986434235,0.390438634128947,-0.875980848206283,-5.57269456404353,-0.692317597508384,"JAZF1-AS1","JAZF1 antisense RNA 1",TRUE
+"212592_at",0.562414216355319,0.0550327582533325,-2.02544715072073,-4.11756337081637,-1.50366648068827,"JCHAIN","joining chain of multimeric IgA and IgM",TRUE
+"239085_at",0.78885145722244,0.315143524519201,1.02777990145651,-5.43787735420363,0.358725491684026,"JDP2","Jun dimerization protein 2",TRUE
+"226267_at",0.812645744389824,0.361339381652693,0.932083841726426,-5.52516627994199,0.565867148612881,"JDP2","Jun dimerization protein 2",TRUE
+"232579_at",0.494968822166536,0.0301100375404829,-2.31730526115908,-3.61612657102341,-1.16573321341231,"JHDM1D-AS1","JHDM1D antisense RNA 1 (head to head)",TRUE
+"223547_at",0.644541215752876,0.114938762754285,-1.64089968237297,-4.70699088051359,-0.858456774505861,"JKAMP","JNK1/MAPK8-associated membrane protein",TRUE
+"223215_s_at",0.78515014907967,0.310513062159116,-1.03789645769781,-5.42819814541125,-0.315647914102009,"JKAMP","JNK1/MAPK8-associated membrane protein",TRUE
+"230007_at",0.26033197578137,0.00387105434495206,3.22502344915312,-1.8470496861991,2.24952374434043,"JMJD1C","jumonji domain containing 1C",TRUE
+"224933_s_at",0.562638706929609,0.0551668103544729,2.02423387740882,-4.11955773532191,0.78510290148983,"JMJD1C","jumonji domain containing 1C",TRUE
+"241661_at",0.65439492367601,0.12337453814819,1.6017438124336,-4.76183098590019,0.767729983954852,"JMJD1C","jumonji domain containing 1C",TRUE
+"228793_at",0.722937902375896,0.199488629322895,1.32250786411165,-5.12191248331599,0.650927557615467,"JMJD1C","jumonji domain containing 1C",TRUE
+"241659_at",0.767011398042819,0.268459783325929,-1.13511037804677,-5.33087450561293,-0.554905421180078,"JMJD1C","jumonji domain containing 1C",TRUE
+"221763_at",0.79782885150643,0.331648861786786,0.992543662598215,-5.47092029514911,0.344651268435639,"JMJD1C","jumonji domain containing 1C",TRUE
+"1552665_at",0.907964244160782,0.61771813242316,0.506197027399078,-5.81564541145252,0.285707612897713,"JMJD1C-AS1","JMJD1C antisense RNA 1",TRUE
+"218560_s_at",0.695744345349551,0.165617058156825,-1.43371103437728,-4.98522627172541,-0.548292771518055,"JMJD4","jumonji domain containing 4",TRUE
+"230810_at",0.920169584950428,0.660384190467032,-0.445354876465818,-5.84353792297724,-0.154420829303702,"JMJD4","jumonji domain containing 4",TRUE
+"222671_s_at",0.933815609540291,0.706779287681688,-0.381072051765518,-5.86920061195468,-0.145345903477908,"JMJD4","jumonji domain containing 4",TRUE
+"212723_at",0.868362470085218,0.503029373225459,-0.680835400205446,-5.71639909646136,-0.23510357319393,"JMJD6","arginine demethylase and lysine hydroxylase",TRUE
+"1552629_a_at",0.922168942129244,0.667910794045746,0.434803209684628,-5.84801948071516,0.258940355701336,"JMJD6","arginine demethylase and lysine hydroxylase",TRUE
+"212722_s_at",0.927552865877291,0.682445641814088,-0.414566445111162,-5.85631913496998,-0.136149874229634,"JMJD6","arginine demethylase and lysine hydroxylase",TRUE
+"215233_at",0.933548873991014,0.705770854059614,-0.382451080571895,-5.86869135212329,-0.357659587362357,"JMJD6","arginine demethylase and lysine hydroxylase",TRUE
+"222256_s_at",0.822173415758858,0.386306463512287,0.88377621961009,-5.56625392347232,0.556420621119551,"JMJD7///JMJD7-PLA2G4B","jumonji domain containing 7///JMJD7-PLA2G4B readthrough",TRUE
+"224886_at",0.62524538993269,0.0965850141146409,-1.73525890250025,-4.57071009946065,-0.548527313086755,"JMJD8","jumonji domain containing 8",TRUE
+"226352_at",0.390319348126593,0.0129999365878103,-2.70101493911649,-2.90031734166282,-0.978421540259319,"JMY","junction mediating and regulatory protein, p53 cofactor",TRUE
+"241985_at",0.593904766176258,0.0707019737151747,-1.89871695748159,-4.32149378103302,-0.779461235944131,"JMY","junction mediating and regulatory protein, p53 cofactor",TRUE
+"201751_at",0.43534764956199,0.0198185697258307,2.51110456508982,-3.26171027439575,0.848327616943552,"JOSD1","Josephin domain containing 1",TRUE
+"227096_at",0.966561892743893,0.84393736559246,-0.199181413830087,-5.92037856351429,-0.0831630530620213,"JOSD2","Josephin domain containing 2",TRUE
+"1553533_at",0.837067957688307,0.419545988618028,-0.822518876186369,-5.61543224413423,-0.346476855937333,"JPH1","junctophilin 1",TRUE
+"229139_at",0.88113080359582,0.537148483311385,-0.626873619116918,-5.75007343128881,-0.475500148945953,"JPH1","junctophilin 1",TRUE
+"220385_at",0.330171916405281,0.00798062973982188,2.91532564955704,-2.47827276842177,2.5834699920879,"JPH2","junctophilin 2",TRUE
+"229578_at",0.660054711393139,0.127944208872696,1.58145863737656,-4.78983706525526,1.94828517339779,"JPH2","junctophilin 2",TRUE
+"1553174_at",0.897949253801113,0.586443521946665,0.552044729715123,-5.7923295698812,0.330143954232882,"JPH2","junctophilin 2",TRUE
+"220188_at",0.784708646973769,0.308772788628805,1.04172606709775,-5.42451180947663,0.769291225149566,"JPH3","junctophilin 3",TRUE
+"234736_at",0.915742010892393,0.6445961552413,0.467658128202087,-5.83371852828173,0.246949139862217,"JPH3","junctophilin 3",TRUE
+"243679_at",0.955515814503015,0.796060898351955,-0.261580840452891,-5.90641125501128,-0.225859166946382,"JPH3","junctophilin 3",TRUE
+"229294_at",0.990585038880669,0.952229876058348,0.0605888211241563,-5.9378956276091,0.079600850170717,"JPH3","junctophilin 3",TRUE
+"226918_at",0.97897951922649,0.898040569215314,-0.129614935304749,-5.93150411610246,-0.0717671046315962,"JPH4///AP1G2","junctophilin 4///adaptor related protein complex 1 gamma 2 subunit",TRUE
+"1554448_at",0.698391916012681,0.169468298115345,-1.42020117695933,-5.00231815778856,-0.452054445254896,"JPX","JPX transcript, XIST activator (non-protein coding)",TRUE
+"1554447_at",0.729083413548563,0.211042325572465,-1.28798069183167,-5.16246596798246,-0.468513368541038,"JPX","JPX transcript, XIST activator (non-protein coding)",TRUE
+"37872_at",0.769079732636599,0.274421152336669,1.12068816087159,-5.34580176019414,0.289785705162673,"JRK","Jrk helix-turn-helix protein",TRUE
+"214692_s_at",0.843982696905956,0.440275710674928,0.785855802636236,-5.64328316823423,0.578756396935822,"JRK","Jrk helix-turn-helix protein",TRUE
+"1554916_a_at",0.854184492233394,0.464534814098257,0.744268829415415,-5.67342420470972,0.219875290712146,"JRK","Jrk helix-turn-helix protein",TRUE
+"216309_x_at",0.874834820370747,0.521624295758184,0.651184778895119,-5.73523240742974,0.278177046556145,"JRK","Jrk helix-turn-helix protein",TRUE
+"217146_at",0.932633693661011,0.702697254345617,0.386658891255417,-5.86712624558669,0.158161005615193,"JRK","Jrk helix-turn-helix protein",TRUE
+"1560011_at",0.952613441433926,0.782945368731522,-0.278850875071702,-5.90188132306152,-0.203171021699945,"JRK","Jrk helix-turn-helix protein",TRUE
+"1568605_at",0.971216837324271,0.861888709653757,0.176005042002357,-5.92460660229691,0.110632909817067,"JRK","Jrk helix-turn-helix protein",TRUE
+"206734_at",0.766550448794594,0.267286245739276,1.13797708855416,-5.32788733631807,0.908130711787745,"JRKL","JRK-like",TRUE
+"1557790_at",0.933815609540291,0.706752223106383,0.381109052623507,-5.86918697163603,0.122527364222731,"JRKL","JRK-like",TRUE
+"235863_at",0.344817137069397,0.00871121929572959,2.87722255952713,-2.55429598497795,1.635754031207,"JSRP1","junctional sarcoplasmic reticulum protein 1",TRUE
+"200048_s_at",0.645213368083975,0.116435880122139,-1.63377857355754,-4.71704032127931,-0.46677106803817,"JTB","jumping translocation breakpoint",TRUE
+"210434_x_at",0.756198431607818,0.251064631375183,-1.17858915247306,-5.28485816745176,-0.335321473585395,"JTB","jumping translocation breakpoint",TRUE
+"210927_x_at",0.756313947022433,0.251384569603669,-1.1777695979342,-5.28573956131584,-0.35271843522299,"JTB","jumping translocation breakpoint",TRUE
+"201466_s_at",0.879948283821082,0.534846976466315,-0.63045354594152,-5.74792211982169,-0.413905520882784,"JUN","Jun proto-oncogene, AP-1 transcription factor subunit",TRUE
+"213281_at",0.928777626237599,0.686575930995819,0.408848218410063,-5.85859386371827,0.134308783564226,"JUN","Jun proto-oncogene, AP-1 transcription factor subunit",TRUE
+"201465_s_at",0.941812807463266,0.738805835249976,0.337648849098703,-5.88430704012309,0.276885535257576,"JUN","Jun proto-oncogene, AP-1 transcription factor subunit",TRUE
+"201464_x_at",0.960695382534282,0.821500659952367,-0.228308069767037,-5.91432736389599,-0.126206150675699,"JUN","Jun proto-oncogene, AP-1 transcription factor subunit",TRUE
+"201473_at",0.42796179417767,0.018576001138062,2.54059289354086,-3.20645681746317,1.57899628415989,"JUNB","JunB proto-oncogene, AP-1 transcription factor subunit",TRUE
+"203752_s_at",0.0560907825756854,0.000109559310470354,-4.69174684291591,1.29181709946903,-1.22199898889375,"JUND","JunD proto-oncogene, AP-1 transcription factor subunit",TRUE
+"214326_x_at",0.240221409886232,0.00319855850749295,-3.30546590397808,-1.67977937232862,-1.50059535081028,"JUND","JunD proto-oncogene, AP-1 transcription factor subunit",TRUE
+"203751_x_at",0.413584432973372,0.0166568435556903,-2.58997670877288,-3.11319351937631,-1.16605098532959,"JUND","JunD proto-oncogene, AP-1 transcription factor subunit",TRUE
+"229117_s_at",0.60998004334651,0.0821035711373333,1.82122863910894,-4.44164927930481,1.27939651792197,"JUND","JunD proto-oncogene, AP-1 transcription factor subunit",TRUE
+"201015_s_at",0.80432278464825,0.343001189700203,0.969007121063455,-5.49240794944708,0.745820636203579,"JUP","junction plakoglobin",TRUE
+"224157_at",0.959584210327095,0.817509605929505,-0.233509618370467,-5.91316035680188,-0.109887897425501,"KAAG1","kidney associated antigen 1",TRUE
+"206078_at",0.181652655810598,0.00170107288111616,-3.5689115309418,-1.12474083313702,-1.54698996090722,"KALRN","kalirin, RhoGEF kinase",TRUE
+"227750_at",0.61823092358054,0.0891812948199309,-1.77770960262246,-4.50755173944611,-0.824302473655434,"KALRN","kalirin, RhoGEF kinase",TRUE
+"230596_at",0.73826901296725,0.225159893019852,1.24772027227879,-5.20859794520351,0.802531301609939,"KALRN","kalirin, RhoGEF kinase",TRUE
+"232756_at",0.784708646973769,0.308770054524309,-1.04173209568946,-5.42450599679224,-0.642279676198656,"KALRN","kalirin, RhoGEF kinase",TRUE
+"205635_at",0.904832003218088,0.609602628720729,-0.517985038189525,-5.80983852614848,-0.353832623784236,"KALRN","kalirin, RhoGEF kinase",TRUE
+"236651_at",0.94118897722809,0.736589974998007,0.340631044546466,-5.88332726021241,0.276058560019793,"KALRN","kalirin, RhoGEF kinase",TRUE
+"232717_at",0.986260660718739,0.932616204845898,0.0855198465553502,-5.93612190205127,0.0621696696741489,"KALRN","kalirin, RhoGEF kinase",TRUE
+"238789_at",0.66641022729301,0.133196725447792,1.55887275401563,-4.82069059005867,0.590022890497666,"KANK1","KN motif and ankyrin repeat domains 1",TRUE
+"213005_s_at",0.739508010556618,0.227595628947524,1.2409709824217,-5.2162085746733,0.990505785864192,"KANK1","KN motif and ankyrin repeat domains 1",TRUE
+"237162_at",0.819193107051406,0.375759104994711,-0.903924335938475,-5.54936254581171,-0.504317986814303,"KANK1","KN motif and ankyrin repeat domains 1",TRUE
+"221068_at",0.44258805251056,0.0205813849555203,2.49384478868531,-3.29389533976716,1.22420566471264,"KANK2","KN motif and ankyrin repeat domains 2",TRUE
+"1569602_at",0.69866353626144,0.16996369518398,1.41848128895728,-5.0044845361104,0.793684474495366,"KANK2","KN motif and ankyrin repeat domains 2",TRUE
+"218418_s_at",0.806221445484273,0.346978553940265,0.960887224402866,-5.49971181844239,0.459003546491806,"KANK2","KN motif and ankyrin repeat domains 2",TRUE
+"213715_s_at",0.721094750464234,0.197369601110147,1.32900847640184,-5.11417595233623,1.011900316986,"KANK3","KN motif and ankyrin repeat domains 3",TRUE
+"229125_at",0.00539379064478529,1.57842981831851e-06,6.47440590477298,4.95543256470982,4.91335692241084,"KANK4","KN motif and ankyrin repeat domains 4",TRUE
+"243589_at",0.560168522189245,0.0541675533025064,2.03334185293225,-4.10456683725938,1.09350454989234,"KANSL1","KAT8 regulatory NSL complex subunit 1",TRUE
+"225117_at",0.923113737920869,0.670431414441964,-0.431280754293856,-5.84949206728064,-0.11935396359484,"KANSL1","KAT8 regulatory NSL complex subunit 1",TRUE
+"229857_s_at",0.946416600885596,0.757795290673604,0.312216512968782,-5.89231618958124,0.26667842537099,"KANSL1-AS1","KANSL1 antisense RNA 1",TRUE
+"230388_s_at",0.957174671135192,0.806108556429288,-0.248405517618175,-5.90967371341008,-0.124285689655304,"KANSL1-AS1","KANSL1 antisense RNA 1",TRUE
+"230561_s_at",0.69385705848116,0.163248942451049,-1.44214407137266,-4.97449021921779,-0.553688347961586,"KANSL1L","KAT8 regulatory NSL complex subunit 1 like",TRUE
+"1554791_a_at",0.801505153621972,0.338237373745217,-0.978817695422933,-5.48350849884907,-0.744109071224163,"KANSL1L","KAT8 regulatory NSL complex subunit 1 like",TRUE
+"215046_at",0.831487912516861,0.40590941070874,0.847260085752733,-5.59596597158346,0.473426138571434,"KANSL1L","KAT8 regulatory NSL complex subunit 1 like",TRUE
+"231252_at",0.908709061737317,0.620869074837108,-0.501639794735445,-5.8178553974005,-0.254335530670609,"KANSL1L","KAT8 regulatory NSL complex subunit 1 like",TRUE
+"239682_at",0.955735662836499,0.797927588913876,0.259129570875606,-5.9070309181818,0.123466327510383,"KANSL1L","KAT8 regulatory NSL complex subunit 1 like",TRUE
+"221821_s_at",0.56861088242915,0.0580372399155211,-1.9988640626235,-4.16107794640957,-0.54537499359706,"KANSL2","KAT8 regulatory NSL complex subunit 2",TRUE
+"224318_s_at",0.76912869907427,0.274776998565293,1.11983454394304,-5.3466799777471,0.349780832161793,"KANSL3","KAT8 regulatory NSL complex subunit 3",TRUE
+"1558652_at",0.774230543658252,0.289421972961993,1.08537996145344,-5.38163122818362,0.848874737722523,"KANSL3","KAT8 regulatory NSL complex subunit 3",TRUE
+"220950_s_at",0.980174445251813,0.906850976612737,0.11835737158954,-5.93286277521691,0.0794780781657991,"KANSL3","KAT8 regulatory NSL complex subunit 3",TRUE
+"223756_at",0.994202932312539,0.97361879478391,0.0334455048790972,-5.93913866574308,0.0259714700745564,"KANSL3","KAT8 regulatory NSL complex subunit 3",TRUE
+"200079_s_at",0.941812807463266,0.738908900598908,-0.337510215705889,-5.88435237991077,-0.109600384136819,"KARS","lysyl-tRNA synthetase",TRUE
+"200840_at",0.976330538523238,0.885532286345273,-0.145627371196516,-5.92935944740286,-0.0418766805013018,"KARS","lysyl-tRNA synthetase",TRUE
+"202182_at",0.975839102149969,0.884421674052811,-0.147050941092597,-5.92915672277523,-0.0431136013257305,"KAT2A","lysine acetyltransferase 2A",TRUE
+"203845_at",0.638134354959023,0.109493290045876,-1.66747775500922,-4.66918845798919,-0.772728469693398,"KAT2B","lysine acetyltransferase 2B",TRUE
+"206689_x_at",0.757479140651,0.253564262339593,-1.17220667942525,-5.2917080625144,-0.363194145243105,"KAT5","lysine acetyltransferase 5",TRUE
+"214258_x_at",0.794443786143158,0.326399859285734,-1.00361441015545,-5.46065119220195,-0.293470364001443,"KAT5","lysine acetyltransferase 5",TRUE
+"209192_x_at",0.821424121108148,0.383616707972116,-0.888879724633558,-5.56200868703386,-0.268441935177636,"KAT5","lysine acetyltransferase 5",TRUE
+"226547_at",0.457032025390949,0.0226036631714639,-2.4508168077372,-3.37362064199747,-1.14339543976006,"KAT6A","lysine acetyltransferase 6A",TRUE
+"202423_at",0.615637099066718,0.085948556654814,-1.79720230260547,-4.47817622767273,-0.738062992531841,"KAT6A","lysine acetyltransferase 6A",TRUE
+"1559142_at",0.875910327419244,0.523944165674374,-0.647526990752064,-5.73750001566289,-0.378662021139973,"KAT6A","lysine acetyltransferase 6A",TRUE
+"216361_s_at",0.997020076059336,0.984638244662092,0.0194727836607754,-5.93949879330758,0.0190533930482406,"KAT6A","lysine acetyltransferase 6A",TRUE
+"1562236_at",0.634072872504683,0.104924395554901,1.69065306674135,-4.63584955970609,1.49100807616193,"KAT6B","lysine acetyltransferase 6B",TRUE
+"212462_at",0.755719147268412,0.250093089308131,-1.18108264134813,-5.28217324009909,-0.555624466864044,"KAT6B","lysine acetyltransferase 6B",TRUE
+"211874_s_at",0.831875452294783,0.407654044918641,0.844065611602945,-5.59850966326478,0.307635559865794,"KAT6B","lysine acetyltransferase 6B",TRUE
+"212452_x_at",0.944634074547624,0.750956013721308,0.321351192843883,-5.88951091730677,0.123404220635544,"KAT6B","lysine acetyltransferase 6B",TRUE
+"214496_x_at",0.99240560748784,0.964634586372954,-0.0448424513720144,-5.93870411953125,-0.0157349179082491,"KAT6B","lysine acetyltransferase 6B",TRUE
+"200049_at",0.780237570670818,0.301686641625268,-1.05747935911715,-5.40921954655444,-0.468722442715455,"KAT7","lysine acetyltransferase 7",TRUE
+"214885_at",0.371800074485131,0.0112339043996239,-2.7656974668331,-2.77440895860774,-0.753284749076956,"KAT8","lysine acetyltransferase 8",TRUE
+"221820_s_at",0.635174103121116,0.10605217639758,-1.68485423502474,-4.64422413213216,-0.685317478111795,"KAT8","lysine acetyltransferase 8",TRUE
+"205526_s_at",0.771153198056133,0.280040064627504,1.10730237181891,-5.35950504210617,0.361516152708349,"KATNA1","katanin catalytic subunit A1",TRUE
+"223790_at",0.279325273101419,0.0045016339116058,3.16107788027101,-1.9791349976271,1.29028952556493,"KATNAL1","katanin catalytic subunit A1 like 1",TRUE
+"227713_at",0.439734782930756,0.0203078249090107,2.49996486072951,-3.28249622968678,1.06067168480125,"KATNAL1","katanin catalytic subunit A1 like 1",TRUE
+"233644_at",0.806735395676905,0.348004446323997,-0.958803128518026,-5.50157740719402,-0.693514200058305,"KATNAL2","katanin catalytic subunit A1 like 2",TRUE
+"233649_at",0.863559206655094,0.48868115702344,0.704139394531097,-5.70103462860371,0.593855073731413,"KATNAL2","katanin catalytic subunit A1 like 2",TRUE
+"1554234_at",0.953844019807428,0.786852028286989,-0.273697910864434,-5.90326303566973,-0.238787385465239,"KATNAL2","katanin catalytic subunit A1 like 2",TRUE
+"203162_s_at",0.832792886465252,0.40979097315483,-0.840164679717165,-5.60160372751367,-0.322549766091482,"KATNB1","katanin regulatory subunit B1",TRUE
+"229077_at",0.952293443370532,0.781526645917002,0.280724102532564,-5.9013726975624,0.0900865553723507,"KATNB1","katanin regulatory subunit B1",TRUE
+"203163_at",0.989638901366417,0.949884700856484,-0.0635673957206621,-5.93771554096705,-0.0294026124138007,"KATNB1","katanin regulatory subunit B1",TRUE
+"222745_s_at",0.591331966259927,0.068683118749651,1.9135632237619,-4.29807158251268,0.700285524041499,"KATNBL1","katanin regulatory subunit B1 like 1",TRUE
+"1559658_at",0.677509122383198,0.145079611893895,1.51037073932777,-4.88575933668946,0.571460044277744,"KATNBL1","katanin regulatory subunit B1 like 1",TRUE
+"218791_s_at",0.830635993561085,0.404349733389272,-0.850123326626102,-5.59367841714212,-0.280257220721403,"KATNBL1","katanin regulatory subunit B1 like 1",TRUE
+"232094_at",0.879997387014318,0.53519292387746,0.62991490589548,-5.74824656226325,0.502866720100155,"KATNBL1","katanin regulatory subunit B1 like 1",TRUE
+"221000_s_at",0.536485356116248,0.0433407557012431,-2.14305233894977,-3.92057367498715,-1.1591149395828,"KAZALD1","Kazal type serine peptidase inhibitor domain 1",TRUE
+"1568598_at",0.572924743912668,0.0601374504858674,-1.98099832583119,-4.19010625043874,-2.09612116342708,"KAZALD1","Kazal type serine peptidase inhibitor domain 1",TRUE
+"217511_at",0.812302873476553,0.358938818948625,-0.936844226456168,-5.52100840742955,-0.543537498872305,"KAZALD1","Kazal type serine peptidase inhibitor domain 1",TRUE
+"229144_at",0.634202341398092,0.105084976754202,-1.68982417222545,-4.63704796481033,-0.714181519759926,"KAZN","kazrin, periplakin interacting protein",TRUE
+"213478_at",0.643515428391208,0.114179116064437,-1.6445428341249,-4.70183663579817,-0.975677867482185,"KAZN","kazrin, periplakin interacting protein",TRUE
+"215138_s_at",0.943177611554239,0.744678288583222,-0.329760458003422,-5.88685762680609,-0.190102014635543,"KAZN","kazrin, periplakin interacting protein",TRUE
+"213752_at",0.957571530817866,0.809019158319391,-0.244597379311175,-5.91058546614463,-0.157306626043392,"KAZN","kazrin, periplakin interacting protein",TRUE
+"204301_at",0.883875568487877,0.542206556599502,-0.619034740974213,-5.75474290304041,-0.588950880441856,"KBTBD11","kelch repeat and BTB domain containing 11",TRUE
+"244771_at",0.885312914741353,0.546590532775306,0.612272050645554,-5.75872580717498,0.443591313807803,"KBTBD12","kelch repeat and BTB domain containing 12",TRUE
+"223585_x_at",0.695739345331756,0.165124835994872,1.4354558487217,-4.98300917875894,0.435594261636972,"KBTBD2","kelch repeat and BTB domain containing 2",TRUE
+"223584_s_at",0.743553048228796,0.233973741217477,1.2235542979157,-5.235683568632,0.375178755466724,"KBTBD2","kelch repeat and BTB domain containing 2",TRUE
+"212447_at",0.965883239653478,0.8402489934413,-0.203956773850327,-5.91944273681053,-0.0607472319834095,"KBTBD2","kelch repeat and BTB domain containing 2",TRUE
+"228777_at",0.98687728101116,0.93863239093913,-0.0778674889188262,-5.93673068000607,-0.0313463871512374,"KBTBD3","kelch repeat and BTB domain containing 3",TRUE
+"223765_s_at",0.795265846168267,0.32737877232125,-1.00154045830125,-5.46258283603669,-0.448194796356402,"KBTBD4","kelch repeat and BTB domain containing 4",TRUE
+"218569_s_at",0.860567464069796,0.480071104890773,-0.718312822351811,-5.69144900791817,-0.292526460545245,"KBTBD4","kelch repeat and BTB domain containing 4",TRUE
+"1553111_a_at",0.694519360341564,0.164047433082069,-1.43928964656232,-4.97812992750706,-0.528908814949438,"KBTBD6","kelch repeat and BTB domain containing 6",TRUE
+"226479_at",0.774230543658252,0.286187763346017,-1.09287844448283,-5.37410735660646,-0.389007850148291,"KBTBD6","kelch repeat and BTB domain containing 6",TRUE
+"229970_at",0.615821255316333,0.086632444044596,-1.79302651750175,-4.48448876292643,-0.856743405598264,"KBTBD7","kelch repeat and BTB domain containing 7",TRUE
+"229298_at",0.6772176958801,0.14474560574403,-1.5116886543752,-4.88401290568816,-0.641032041389523,"KBTBD7","kelch repeat and BTB domain containing 7",TRUE
+"223412_at",0.69794616906853,0.168956901608342,-1.42198084225228,-5.00007421557754,-0.680019447107483,"KBTBD7","kelch repeat and BTB domain containing 7",TRUE
+"239835_at",0.893175412268596,0.567657648272284,0.58016434078446,-5.77705904277015,0.376667807047694,"KBTBD8","kelch repeat and BTB domain containing 8",TRUE
+"236161_at",0.805746717966166,0.345971732136773,0.962936657938261,-5.49787364631882,0.729044050055837,"KCCAT333","renal clear cell carcinoma-associated transcript 333",TRUE
+"222471_s_at",0.632216562924782,0.103380541811672,1.69867760410556,-4.62422490121778,0.775504792377376,"KCMF1","potassium channel modulatory factor 1",TRUE
+"242887_at",0.671298718565642,0.137427463317883,1.54121029039955,-4.8445747289986,0.745118362136176,"KCMF1","potassium channel modulatory factor 1",TRUE
+"217938_s_at",0.690015152288705,0.159666200707051,1.45509187216072,-4.95790659773967,0.488119919560026,"KCMF1","potassium channel modulatory factor 1",TRUE
+"240430_at",0.827866702343255,0.397300643945498,0.86315302785097,-5.58317768676736,0.538797383291404,"KCMF1","potassium channel modulatory factor 1",TRUE
+"230849_at",0.62443408969229,0.0959787826318355,1.73862803278336,-4.56573870407369,0.927851336959802,"KCNA1","potassium voltage-gated channel subfamily A member 1",TRUE
+"208479_at",0.954429420677162,0.790631598009357,0.268719776453662,-5.90457356970552,0.157823906175034,"KCNA1","potassium voltage-gated channel subfamily A member 1",TRUE
+"208560_at",0.807528762746328,0.348873102969017,0.957041718204039,-5.50315125308803,0.487107763130161,"KCNA10","potassium voltage-gated channel subfamily A member 10",TRUE
+"239118_at",0.957430653957785,0.807326076176704,0.24681210025615,-5.91005691663943,0.144757112139361,"KCNA2","potassium voltage-gated channel subfamily A member 2",TRUE
+"208564_at",0.997890350692744,0.990190878849259,0.0124336976937972,-5.93960818260958,0.00776300039765809,"KCNA2","potassium voltage-gated channel subfamily A member 2",TRUE
+"207237_at",0.860994442844737,0.481070310644058,-0.716660454765442,-5.69257588320834,-0.391800098494324,"KCNA3","potassium voltage-gated channel subfamily A member 3",TRUE
+"207248_at",0.869082033398093,0.50597293650028,0.676101379882552,-5.71945987612202,0.439210438187586,"KCNA4","potassium voltage-gated channel subfamily A member 4",TRUE
+"206762_at",0.871744769522775,0.513718394349371,0.663718015547922,-5.72736964132658,0.22001847108886,"KCNA5","potassium voltage-gated channel subfamily A member 5",TRUE
+"1553347_s_at",0.919695424525124,0.658717985269777,0.447697674329154,-5.84252857490444,0.3340047903892,"KCNA6","potassium voltage-gated channel subfamily A member 6",TRUE
+"232936_at",0.728385463227073,0.209646525557881,1.29207282539506,-5.15770713094432,0.537117823802123,"KCNA7","potassium voltage-gated channel subfamily A member 7",TRUE
+"210078_s_at",0.456898036702485,0.0223635095398839,2.45573490017205,-3.36454548564096,2.18386584745823,"KCNAB1","potassium voltage-gated channel subfamily A member regulatory beta subunit 1",TRUE
+"210471_s_at",0.588653540532996,0.0673595994085617,1.9235054002016,-4.28231554051541,1.18445735928201,"KCNAB1","potassium voltage-gated channel subfamily A member regulatory beta subunit 1",TRUE
+"208213_s_at",0.610455440146151,0.0829908176070143,1.81559938134034,-4.45023878221238,1.50513703167733,"KCNAB1","potassium voltage-gated channel subfamily A member regulatory beta subunit 1",TRUE
+"210079_x_at",0.671461974860898,0.13747316591848,1.54102195507635,-4.84482824655464,1.2534914718434,"KCNAB1","potassium voltage-gated channel subfamily A member regulatory beta subunit 1",TRUE
+"231524_at",0.919375181609246,0.657276151524448,0.449727046365173,-5.8416500618696,0.239452823701577,"KCNAB1","potassium voltage-gated channel subfamily A member regulatory beta subunit 1",TRUE
+"211791_s_at",0.775757729721894,0.293065526091522,1.0770043175977,-5.38998058531245,0.816343434345217,"KCNAB2","potassium voltage-gated channel subfamily A regulatory beta subunit 2",TRUE
+"203402_at",0.809930331505913,0.3536040140666,0.94750049303004,-5.51163042081331,0.867245558258593,"KCNAB2","potassium voltage-gated channel subfamily A regulatory beta subunit 2",TRUE
+"221413_at",0.594303508881191,0.071239591120847,-1.8948261242651,-4.32761110224717,-1.47389550099447,"KCNAB3","potassium voltage-gated channel subfamily A regulatory beta subunit 3",TRUE
+"240869_at",0.67842163564685,0.14588116974774,1.50721806855062,-4.88993214620425,0.525455414753466,"KCNB1","potassium voltage-gated channel subfamily B member 1",TRUE
+"217637_at",0.756006545489432,0.250860918426453,1.17911138999368,-5.28429624523443,0.40439837233509,"KCNB1","potassium voltage-gated channel subfamily B member 1",TRUE
+"231053_at",0.941106542715586,0.736019004052528,0.341399990150088,-5.88307324676457,0.222967553187439,"KCNB1","potassium voltage-gated channel subfamily B member 1",TRUE
+"211006_s_at",0.998347572104896,0.992825460632004,-0.00909408040789349,-5.93964319958899,-0.00389058737687442,"KCNB1","potassium voltage-gated channel subfamily B member 1",TRUE
+"208123_at",0.384135218769668,0.0124238840332977,2.72114808770853,-2.86127149253414,1.6520822396963,"KCNB2","potassium voltage-gated channel subfamily B member 2",TRUE
+"208172_s_at",0.854040699678541,0.463273870941462,0.746397820716864,-5.67191882511902,0.463919230520252,"KCNB2","potassium voltage-gated channel subfamily B member 2",TRUE
+"230547_at",0.731054546207485,0.213721955812687,-1.28018293794769,-5.17149858714285,-1.56194112899733,"KCNC1","potassium voltage-gated channel subfamily C member 1",TRUE
+"208477_at",0.773156930607264,0.284053110219737,-1.09786118793445,-5.36908223757782,-0.754353390416552,"KCNC1","potassium voltage-gated channel subfamily C member 1",TRUE
+"222289_at",0.895366192695711,0.573651797467101,0.571141666377078,-5.78203896593556,0.347613759033114,"KCNC2","potassium voltage-gated channel subfamily C member 2",TRUE
+"240614_at",0.990810941805126,0.955134990233355,-0.0568998514550587,-5.93810669154626,-0.0341385095630318,"KCNC2","potassium voltage-gated channel subfamily C member 2",TRUE
+"207600_at",0.78515014907967,0.310467634217003,-1.03799623265108,-5.42810225835543,-0.494602520502895,"KCNC3","potassium voltage-gated channel subfamily C member 3",TRUE
+"230531_at",0.886148073306164,0.548878402271935,-0.608754214082443,-5.76078096308212,-0.453951645859955,"KCNC3","potassium voltage-gated channel subfamily C member 3",TRUE
+"243893_at",0.962050375516713,0.827657190639374,-0.220296809232515,-5.91607357899855,-0.0780770729018201,"KCNC3","potassium voltage-gated channel subfamily C member 3",TRUE
+"228436_at",0.748632141741128,0.241466960443379,1.20354595989145,-5.25776249162643,0.477936977322151,"KCNC4","potassium voltage-gated channel subfamily C member 4",TRUE
+"235467_s_at",0.760227035076299,0.258156272840143,1.16060250920972,-5.30407862866533,1.07195541815006,"KCNC4","potassium voltage-gated channel subfamily C member 4",TRUE
+"208251_at",0.760503623430467,0.259621401578961,1.15693231016337,-5.30796876044792,0.71785994583028,"KCNC4","potassium voltage-gated channel subfamily C member 4",TRUE
+"206842_at",0.938034425016976,0.725756419699462,0.355257316912933,-5.87839859114531,0.21013941301976,"KCND1","potassium voltage-gated channel subfamily D member 1",TRUE
+"207103_at",0.803583569469174,0.34197977021796,0.971102735640066,-5.49051382736411,1.37140536435987,"KCND2","potassium voltage-gated channel subfamily D member 2",TRUE
+"213832_at",0.697172073261335,0.167638128737716,-1.4265902000433,-4.99425166101556,-0.730025199245038,"KCND3","potassium voltage-gated channel subfamily D member 3",TRUE
+"211301_at",0.730048787941067,0.212461029719922,-1.28384278842054,-5.16726497257393,-0.710651487207211,"KCND3","potassium voltage-gated channel subfamily D member 3",TRUE
+"211827_s_at",0.819018525257656,0.373871330318787,-0.907569587325348,-5.5462689126025,-0.485095253206625,"KCND3","potassium voltage-gated channel subfamily D member 3",TRUE
+"215014_at",0.823736995840224,0.390828740907019,-0.875247685980423,-5.57329758787545,-0.963048142489635,"KCND3","potassium voltage-gated channel subfamily D member 3",TRUE
+"208514_at",0.640337040581689,0.111149163989042,1.65928010822342,-4.68089752222817,0.849164714709585,"KCNE1","potassium voltage-gated channel subfamily E regulatory subunit 1",TRUE
+"236407_at",0.678455276397227,0.145937351073175,-1.50699762924519,-4.89022365417078,-1.39426531568477,"KCNE1","potassium voltage-gated channel subfamily E regulatory subunit 1",TRUE
+"221095_s_at",0.973433731874338,0.871412822675991,0.163749546991351,-5.9266318444174,0.0590499333482883,"KCNE2","potassium voltage-gated channel subfamily E regulatory subunit 2",TRUE
+"222922_at",0.744307803443383,0.235099848181118,1.2205167564101,-5.23905574198411,0.876717278212572,"KCNE3","potassium voltage-gated channel subfamily E regulatory subunit 3",TRUE
+"227647_at",0.896599256925387,0.581352502396194,0.559619945979332,-5.78828819898954,0.330114643763138,"KCNE3","potassium voltage-gated channel subfamily E regulatory subunit 3",TRUE
+"222923_s_at",0.936143408699214,0.714800603354869,0.370129430489414,-5.87317726921386,0.202613802110894,"KCNE3","potassium voltage-gated channel subfamily E regulatory subunit 3",TRUE
+"222379_at",0.779119049888702,0.300247615567534,1.060710502625,-5.40605750494274,0.820650337555244,"KCNE4","potassium voltage-gated channel subfamily E regulatory subunit 4",TRUE
+"1552507_at",0.877223961993707,0.526429004102912,-0.643618923735825,-5.73990922628313,-0.320267051499632,"KCNE4","potassium voltage-gated channel subfamily E regulatory subunit 4",TRUE
+"1552508_at",0.947778780715578,0.761430607356209,0.307372170205581,-5.89377137589034,0.215647471775251,"KCNE4","potassium voltage-gated channel subfamily E regulatory subunit 4",TRUE
+"220010_at",0.769847953580141,0.278348784085266,1.11131073936149,-5.35541691393127,0.926409100869658,"KCNE5","potassium voltage-gated channel subfamily E regulatory subunit 5",TRUE
+"210263_at",0.946416600885596,0.757766203257204,-0.31225530482333,-5.8923044459581,-0.34359400808284,"KCNF1","potassium voltage-gated channel modifier subfamily F member 1",TRUE
+"214595_at",0.83633038614858,0.417729535379773,0.825784875520522,-5.6128934850714,1.01379381802134,"KCNG1","potassium voltage-gated channel modifier subfamily G member 1",TRUE
+"211053_at",0.924696623416105,0.674328360051909,-0.425845821603416,-5.85174109352099,-0.173003548550716,"KCNG1","potassium voltage-gated channel modifier subfamily G member 1",TRUE
+"208550_x_at",0.929088231432081,0.68795018434725,-0.40694869730784,-5.85934262066763,-0.180221958248099,"KCNG2","potassium voltage-gated channel modifier subfamily G member 2",TRUE
+"1552897_a_at",0.827825169467994,0.396889269869134,0.863917996096361,-5.58255657286794,0.703425465982368,"KCNG3","potassium voltage-gated channel modifier subfamily G member 3",TRUE
+"1552898_a_at",0.906292059758115,0.612979979329768,-0.513070398000015,-5.81227536482487,-0.336319433839802,"KCNG3","potassium voltage-gated channel modifier subfamily G member 3",TRUE
+"1552598_at",0.552420073963858,0.050113760454345,2.07190050761251,-4.04061367105674,1.55566592704477,"KCNG4","potassium voltage-gated channel modifier subfamily G member 4",TRUE
+"207635_s_at",0.896599256925387,0.581366929245886,0.55959843283258,-5.78829975191294,0.492619077533219,"KCNH1","potassium voltage-gated channel subfamily H member 1",TRUE
+"210036_s_at",0.827121837335454,0.39588388406459,-0.865789710179982,-5.58103468160726,-0.537270366492234,"KCNH2","potassium voltage-gated channel subfamily H member 2",TRUE
+"205262_at",0.918519404912537,0.653992536147054,-0.454355899408352,-5.839631658997,-0.454161059936223,"KCNH2","potassium voltage-gated channel subfamily H member 2",TRUE
+"223726_at",0.94118897722809,0.736838706274223,0.340296135342337,-5.88343771703456,0.272194044527178,"KCNH3","potassium voltage-gated channel subfamily H member 3",TRUE
+"220802_at",0.646750698976317,0.117826856641141,-1.6272308811792,-4.72625088435001,-0.815574297274864,"KCNH4","potassium voltage-gated channel subfamily H member 4",TRUE
+"1555304_a_at",0.790817398514927,0.320560000830655,1.01607765702101,-5.4489668974913,0.729921740982925,"KCNH5","potassium voltage-gated channel subfamily H member 5",TRUE
+"1555074_a_at",0.819780516863333,0.37752617226203,0.900523104442032,-5.55223871062783,0.458456236878658,"KCNH5","potassium voltage-gated channel subfamily H member 5",TRUE
+"242502_at",0.885029460971826,0.545975660126964,0.613218808445076,-5.7581707510907,0.371370522166021,"KCNH5","potassium voltage-gated channel subfamily H member 5",TRUE
+"221023_s_at",0.646224068018448,0.117185458192564,1.63024201026599,-4.7220186991565,0.913578406919139,"KCNH6","potassium voltage-gated channel subfamily H member 6",TRUE
+"211046_at",0.796378050779806,0.328994806272766,0.998126077625685,-5.46575503401556,0.93584534805214,"KCNH6","potassium voltage-gated channel subfamily H member 6",TRUE
+"211045_s_at",0.931370027472813,0.696701738192719,-0.394887435526142,-5.86401684647124,-0.322115173450988,"KCNH6","potassium voltage-gated channel subfamily H member 6",TRUE
+"1555316_a_at",0.866505802716545,0.497541530324339,0.689703294759525,-5.71061063047098,0.519641019980266,"KCNH7","potassium voltage-gated channel subfamily H member 7",TRUE
+"224099_at",0.902268042923638,0.601068830019945,0.530461366819346,-5.80355073225716,0.164596877416678,"KCNH7","potassium voltage-gated channel subfamily H member 7",TRUE
+"1552742_at",0.661974206478491,0.129783461445764,1.57346379235024,-4.80079825240021,1.24778154007422,"KCNH8","potassium voltage-gated channel subfamily H member 8",TRUE
+"221307_at",0.945498722604777,0.754020158907758,-0.31725525453106,-5.89077869266047,-0.14320621126542,"KCNIP1","potassium voltage-gated channel interacting protein 1",TRUE
+"221321_s_at",0.539609110035715,0.0443044371892725,2.13234249338058,-3.93880697589445,1.21483590436033,"KCNIP2","potassium voltage-gated channel interacting protein 2",TRUE
+"1555230_a_at",0.704071755097914,0.175853751945443,-1.39833371763194,-5.02970153524783,-1.16459687730961,"KCNIP2","potassium voltage-gated channel interacting protein 2",TRUE
+"224528_s_at",0.870517518639056,0.509606632010621,0.670278753403908,-5.72319646578835,0.306432494379474,"KCNIP2","potassium voltage-gated channel interacting protein 2",TRUE
+"223727_at",0.922623399611851,0.669077041392558,0.433172738387682,-5.8487025727171,0.12543919251983,"KCNIP2","potassium voltage-gated channel interacting protein 2",TRUE
+"237266_at",0.789243374849817,0.315524127800042,-1.02695302670756,-5.43866470140875,-0.63801344068944,"KCNIP2-AS1","KCNIP2 antisense RNA 1",TRUE
+"231774_at",0.505377544152491,0.0329371410065188,2.27489003980483,-3.6915413296063,1.19679927837783,"KCNIP3","potassium voltage-gated channel interacting protein 3",TRUE
+"233688_at",0.796327569283512,0.328619680631782,0.998917610780337,-5.46502051993311,0.550939439587703,"KCNIP3","potassium voltage-gated channel interacting protein 3",TRUE
+"1555694_a_at",0.801917957653237,0.339672387001195,0.975852531737145,-5.48620690347658,0.754905159507953,"KCNIP3","potassium voltage-gated channel interacting protein 3",TRUE
+"228269_x_at",0.89390639630277,0.569749446866282,0.577010178627109,-5.77880852654327,0.672615260316882,"KCNIP3","potassium voltage-gated channel interacting protein 3",TRUE
+"1569355_at",0.896229101808264,0.579818137972183,-0.561909499111105,-5.78705620736098,-0.399768660568331,"KCNIP3","potassium voltage-gated channel interacting protein 3",TRUE
+"236783_at",0.763608121670718,0.263432581453188,1.14745639250604,-5.31796245468726,0.688199726989893,"KCNIP4","potassium voltage-gated channel interacting protein 4",TRUE
+"224530_s_at",0.839519981963042,0.427280374942724,0.808710736585745,-5.62606148985298,0.320016954208865,"KCNIP4","potassium voltage-gated channel interacting protein 4",TRUE
+"210402_at",0.943464796017993,0.746455773628965,0.327377009618969,-5.88761654076101,0.21013387344099,"KCNJ1","potassium voltage-gated channel subfamily J member 1",TRUE
+"210403_s_at",0.957524414951038,0.808339508016244,0.245486279084763,-5.91037389669389,0.123172133803116,"KCNJ1","potassium voltage-gated channel subfamily J member 1",TRUE
+"206692_at",0.82847108093969,0.398529819840782,0.860870357526065,-5.58502805141854,0.448237085465067,"KCNJ10","potassium voltage-gated channel subfamily J member 10",TRUE
+"228581_at",0.831875452294783,0.407665502201269,0.844044661830965,-5.59852631552552,0.450893567982588,"KCNJ10","potassium voltage-gated channel subfamily J member 10",TRUE
+"231740_at",0.383328885347805,0.0122336803114039,-2.72798994002588,-2.84797246536049,-1.87489736973061,"KCNJ11","potassium voltage-gated channel subfamily J member 11",TRUE
+"210179_at",0.816800680706682,0.368950692539564,-0.917128865003285,-5.53810163165103,-0.601313232556989,"KCNJ13","potassium voltage-gated channel subfamily J member 13",TRUE
+"211427_s_at",0.827011327018402,0.395386229260312,-0.866717323237916,-5.58027930399516,-0.731310055125793,"KCNJ13","potassium voltage-gated channel subfamily J member 13",TRUE
+"220776_at",0.840724997651626,0.429949916037258,0.803981058598485,-5.62966347663871,0.254070795685954,"KCNJ14","potassium voltage-gated channel subfamily J member 14",TRUE
+"210119_at",0.00780364644890034,2.71182958443725e-06,6.23913978438196,4.49640196812418,4.52878808087586,"KCNJ15","potassium voltage-gated channel subfamily J member 15",TRUE
+"211806_s_at",0.37499894502533,0.011406003577085,2.75898560939854,-2.78753598630355,0.997098244847412,"KCNJ15","potassium voltage-gated channel subfamily J member 15",TRUE
+"238428_at",0.514490373584066,0.0346498635769325,2.2507873688086,-3.7340299902417,1.10749821570124,"KCNJ15","potassium voltage-gated channel subfamily J member 15",TRUE
+"239464_at",0.767945391174396,0.270529825248958,-1.13007603111592,-5.33610430237076,-0.750344481483585,"KCNJ15","potassium voltage-gated channel subfamily J member 15",TRUE
+"230585_at",0.997623421895415,0.988213146864366,0.0149407799483485,-5.9395747557386,0.0105258379282214,"KCNJ15","potassium voltage-gated channel subfamily J member 15",TRUE
+"219564_at",0.820288124919738,0.378411666850769,0.898822658859013,-5.55367289095506,0.66877805472194,"KCNJ16","potassium voltage-gated channel subfamily J member 16",TRUE
+"222901_s_at",0.968262726161738,0.850689863994609,0.190451088262582,-5.92203233938626,0.140497435301623,"KCNJ16","potassium voltage-gated channel subfamily J member 16",TRUE
+"206765_at",0.918409982899324,0.653603662661274,0.454904753549774,-5.83939098845928,0.367180545598022,"KCNJ2","potassium voltage-gated channel subfamily J member 2",TRUE
+"1558234_at",0.900831880406409,0.596627118284819,0.53698885742053,-5.80020299193283,0.564569329699502,"KCNJ2-AS1","KCNJ2 antisense RNA 1 (head to head)",TRUE
+"233059_at",0.814439884224271,0.365378850631269,-0.92412104658392,-5.53207769581662,-0.857522439289683,"KCNJ3","potassium voltage-gated channel subfamily J member 3",TRUE
+"207141_s_at",0.870980161749509,0.511244563685546,-0.667661738598494,-5.72486581896823,-0.447462463819818,"KCNJ3","potassium voltage-gated channel subfamily J member 3",TRUE
+"207142_at",0.91539387234353,0.643288943760339,-0.469515465746853,-5.83287960711247,-0.429727219993682,"KCNJ3","potassium voltage-gated channel subfamily J member 3",TRUE
+"211451_s_at",0.68747436517451,0.156267167874987,1.4675946631896,-4.94177871908201,0.749627305508667,"KCNJ4","potassium voltage-gated channel subfamily J member 4",TRUE
+"208359_s_at",0.962377536390494,0.828691987439679,-0.218951728030504,-5.91636068047442,-0.190617826328764,"KCNJ4","potassium voltage-gated channel subfamily J member 4",TRUE
+"211304_x_at",0.724568343940805,0.201713655123554,1.31573984435676,-5.12993326852059,0.476414387202905,"KCNJ5","potassium voltage-gated channel subfamily J member 5",TRUE
+"208404_x_at",0.807528762746328,0.34885724461174,0.957073848131456,-5.50312256823603,0.737434321778129,"KCNJ5","potassium voltage-gated channel subfamily J member 5",TRUE
+"237186_at",0.822241803732333,0.387021359287638,-0.882423691286784,-5.56737519540926,-0.33772775010969,"KCNJ5","potassium voltage-gated channel subfamily J member 5",TRUE
+"208397_x_at",0.894136768148992,0.570347214307134,-0.576109908723426,-5.77930617503241,-0.288117401447137,"KCNJ5","potassium voltage-gated channel subfamily J member 5",TRUE
+"211817_s_at",0.974849253960767,0.876654920438182,0.157015149693736,-5.92768267371286,0.103153181631904,"KCNJ5","potassium voltage-gated channel subfamily J member 5",TRUE
+"238780_s_at",0.9802233499944,0.90732612541097,-0.117750705007106,-5.93293249475863,-0.0847276960212442,"KCNJ5","potassium voltage-gated channel subfamily J member 5",TRUE
+"210454_s_at",0.848268984089208,0.448102508452889,0.772290240252037,-5.6532851474262,0.424807809696264,"KCNJ6","potassium voltage-gated channel subfamily J member 6",TRUE
+"232411_at",0.976994788692278,0.890266989951277,-0.139561901313302,-5.93020114726422,-0.0770246607657614,"KCNJ6","potassium voltage-gated channel subfamily J member 6",TRUE
+"205303_at",0.831875452294783,0.407769136769287,-0.843855181879652,-5.59867690916708,-0.866142867935552,"KCNJ8","potassium voltage-gated channel subfamily J member 8",TRUE
+"205304_s_at",0.913140067375992,0.635363717219003,0.480812204117656,-5.82770702530102,0.486760982355794,"KCNJ8","potassium voltage-gated channel subfamily J member 8",TRUE
+"244113_at",0.812302873476553,0.358627541386226,-0.937463062778811,-5.5204664669103,-0.325182371725079,"KCNJ9","potassium voltage-gated channel subfamily J member 9",TRUE
+"207527_at",0.91876780831279,0.654966811225125,-0.452981433969028,-5.84023310730426,-0.260144335589807,"KCNJ9","potassium voltage-gated channel subfamily J member 9",TRUE
+"1566464_at",0.673322568613087,0.139013390229757,1.53470481372733,-4.85331750308412,0.73271134947067,"KCNK1","potassium two pore domain channel subfamily K member 1",TRUE
+"204678_s_at",0.751328854941707,0.244217949886127,1.19631766531616,-5.26566111139594,1.7213548685506,"KCNK1","potassium two pore domain channel subfamily K member 1",TRUE
+"204679_at",0.780237570670818,0.301735690970691,1.05736941878994,-5.4093269834629,1.45574226217366,"KCNK1","potassium two pore domain channel subfamily K member 1",TRUE
+"1566465_at",0.784925710185113,0.310104667608637,1.03879379887964,-5.42733547223057,0.920099874230005,"KCNK1","potassium two pore domain channel subfamily K member 1",TRUE
+"231230_at",0.680586794685785,0.148316953617023,-1.49772382584579,-4.90245633841463,-0.893213383132825,"KCNK10","potassium two pore domain channel subfamily K member 10",TRUE
+"220727_at",0.790817398514927,0.320648341650494,1.01588794836038,-5.44914572774399,0.699438723920032,"KCNK10","potassium two pore domain channel subfamily K member 10",TRUE
+"1556927_at",0.942502815705589,0.74246515859332,-0.332730794544937,-5.88590421715177,-0.338382056995759,"KCNK10","potassium two pore domain channel subfamily K member 10",TRUE
+"220448_at",0.743553048228796,0.234148404951056,-1.22308243880329,-5.23620788566072,-1.72785267326385,"KCNK12","potassium two pore domain channel subfamily K member 12",TRUE
+"221325_at",0.955892698633978,0.800007173738311,-0.256400644817866,-5.90771395206034,-0.202634023800147,"KCNK13","potassium two pore domain channel subfamily K member 13",TRUE
+"220540_at",0.8376750578867,0.422338374864285,-0.81751541814645,-5.61930330152689,-1.03971621348839,"KCNK15","potassium two pore domain channel subfamily K member 15",TRUE
+"1560620_at",0.940668681806864,0.734392668154566,-0.343591383441423,-5.88234623525035,-0.244111362640548,"KCNK15","potassium two pore domain channel subfamily K member 15",TRUE
+"241759_at",0.906053610890338,0.612619842476342,0.513593849221831,-5.81201689813945,0.379854711333897,"KCNK15-AS1","KCNK15 antisense RNA 1 (head to head)",TRUE
+"234554_at",0.937655803006818,0.724268445082809,0.357272326696949,-5.87770354186458,0.172093731148425,"KCNK16","potassium two pore domain channel subfamily K member 16",TRUE
+"224049_at",0.819162667476514,0.375488736919753,0.904445667468155,-5.54892080960531,0.256118718515917,"KCNK17","potassium two pore domain channel subfamily K member 17",TRUE
+"210261_at",0.986889306520757,0.939424470848172,-0.076860358610119,-5.93680655770132,-0.101322171022148,"KCNK2","potassium two pore domain channel subfamily K member 2",TRUE
+"228127_at",0.666643938027574,0.133523491417326,1.55749218568846,-4.82256520381209,1.01906885762983,"KCNK3","potassium two pore domain channel subfamily K member 3",TRUE
+"205952_at",0.912252515563073,0.632445337042332,0.484988070308464,-5.82576452215262,0.396865832082211,"KCNK3","potassium two pore domain channel subfamily K member 3",TRUE
+"235108_at",0.964685626382167,0.836784125371611,0.208447183640403,-5.91854260789296,0.0807577170895586,"KCNK3","potassium two pore domain channel subfamily K member 3",TRUE
+"224552_s_at",0.723655063748891,0.200553533552825,1.31926136216689,-5.12576424820773,0.663681754953813,"KCNK4","potassium two pore domain channel subfamily K member 4",TRUE
+"219615_s_at",0.999569066987949,0.999038888607653,0.00121823857713741,-5.93968275789619,0.00102096626893911,"KCNK5","potassium two pore domain channel subfamily K member 5",TRUE
+"223658_at",0.942450624660433,0.741394378122548,0.334169029814441,-5.8854395373614,0.237771048171444,"KCNK6","potassium two pore domain channel subfamily K member 6",TRUE
+"220412_x_at",0.459080504286235,0.0229309347454176,2.44419213949003,-3.38582940859254,0.873428756940414,"KCNK7","potassium two pore domain channel subfamily K member 7",TRUE
+"224008_s_at",0.630603891142543,0.101739815022287,1.70731801533517,-4.61166181397634,0.496285739231317,"KCNK7","potassium two pore domain channel subfamily K member 7",TRUE
+"224055_x_at",0.959649219607517,0.817846539179142,0.233070239988661,-5.91325994594603,0.137153414291077,"KCNK7","potassium two pore domain channel subfamily K member 7",TRUE
+"238870_at",0.541879135605867,0.0453482507854661,2.12097647702482,-3.95809418533998,1.45165064143526,"KCNK9","potassium two pore domain channel subfamily K member 9",TRUE
+"224072_s_at",0.824541923419694,0.391931823067233,0.873177133021005,-5.57499807987245,0.451014677940789,"KCNK9","potassium two pore domain channel subfamily K member 9",TRUE
+"221584_s_at",0.552420073963858,0.0501890993806137,-2.07115885728118,-4.04185116194477,-2.45785083178178,"KCNMA1","potassium calcium-activated channel subfamily M alpha 1",TRUE
+"228414_at",0.831392326632573,0.405684898067812,-0.847671810421682,-5.59563747185595,-0.555681465907103,"KCNMA1","potassium calcium-activated channel subfamily M alpha 1",TRUE
+"214921_at",0.864894115958506,0.493981525660065,-0.695485740590647,-5.7067976427938,-0.371933007485742,"KCNMA1","potassium calcium-activated channel subfamily M alpha 1",TRUE
+"221583_s_at",0.959451355429682,0.816828449815535,-0.234398024835295,-5.91295842129151,-0.316921298745227,"KCNMA1","potassium calcium-activated channel subfamily M alpha 1",TRUE
+"1569763_at",0.621733119678766,0.0920858674560337,-1.76070767674773,-4.53298221036252,-1.03130732617773,"KCNMA1-AS1","KCNMA1 antisense RNA 1",TRUE
+"1554710_at",0.936992192746977,0.717814817589085,-0.366029403619031,-5.8746378161611,-0.227984937815544,"KCNMB1","potassium calcium-activated channel subfamily M regulatory beta subunit 1",TRUE
+"209948_at",0.983498417373669,0.919568348099556,0.102134849038399,-5.93460394525236,0.0381247904785527,"KCNMB1","potassium calcium-activated channel subfamily M regulatory beta subunit 1",TRUE
+"223823_at",0.706360298056879,0.178403131112138,1.38977990691603,-5.04031754407529,0.675764869956798,"KCNMB2","potassium calcium-activated channel subfamily M regulatory beta subunit 2",TRUE
+"221097_s_at",0.821124695463525,0.381945006950679,0.892063392051,-5.55934895687368,0.337307253395497,"KCNMB2","potassium calcium-activated channel subfamily M regulatory beta subunit 2",TRUE
+"233205_at",0.832605695407954,0.4089779786175,0.841647260800649,-5.60042937956341,0.515976539690682,"KCNMB2-AS1","KCNMB2 antisense RNA 1",TRUE
+"221125_s_at",0.740681080735184,0.230930807892688,1.23181803848759,-5.22647281549253,0.894092130362118,"KCNMB3","potassium calcium-activated channel subfamily M regulatory beta subunit 3",TRUE
+"235930_at",0.51470556386048,0.0349052551121449,2.24728691231026,-3.74017824203627,1.35610440770045,"KCNMB4","potassium calcium-activated channel subfamily M regulatory beta subunit 4",TRUE
+"222857_s_at",0.709346162928153,0.182179036485361,1.37728759841658,-5.05572457622639,0.964928767514746,"KCNMB4","potassium calcium-activated channel subfamily M regulatory beta subunit 4",TRUE
+"219287_at",0.790817398514927,0.320602896373362,1.0159855358607,-5.44905373994792,0.304066654872798,"KCNMB4","potassium calcium-activated channel subfamily M regulatory beta subunit 4",TRUE
+"206231_at",0.378119110146051,0.0115908116800143,-2.75188415787414,-2.80140958554253,-1.05574771076608,"KCNN1","potassium calcium-activated channel subfamily N member 1",TRUE
+"220116_at",0.511772009810211,0.034127976146671,-2.2580142985809,-3.72131844911992,-1.99548240624993,"KCNN2","potassium calcium-activated channel subfamily N member 2",TRUE
+"231103_at",0.596382916302699,0.0728773839329324,1.88312953274605,-4.34594800857335,1.22213985378925,"KCNN3","potassium calcium-activated channel subfamily N member 3",TRUE
+"244040_at",0.849990777966633,0.45255021072134,0.764645512619753,-5.65884922748247,0.489816872795764,"KCNN3","potassium calcium-activated channel subfamily N member 3",TRUE
+"205903_s_at",0.8920930097751,0.564252474396435,0.585311661217286,-5.7741842137736,0.223927207502772,"KCNN3","potassium calcium-activated channel subfamily N member 3",TRUE
+"205902_at",0.97304633500821,0.869344173775299,-0.166409207617627,-5.92620471040891,-0.0441333383525975,"KCNN3","potassium calcium-activated channel subfamily N member 3",TRUE
+"204401_at",0.739340500562926,0.226691444022983,1.24346997249523,-5.21339480405326,1.43757469216868,"KCNN4","potassium calcium-activated channel subfamily N member 4",TRUE
+"211217_s_at",0.862634144901168,0.485712416042201,0.709009927673668,-5.69776115938775,0.239646925391676,"KCNQ1","potassium voltage-gated channel subfamily Q member 1",TRUE
+"204487_s_at",0.877223961993707,0.526489861468511,-0.643523336048709,-5.7399679778028,-0.655012608523682,"KCNQ1","potassium voltage-gated channel subfamily Q member 1",TRUE
+"1562960_at",0.679041081350052,0.146581411419862,1.50447546744821,-4.89355652047854,0.582505369747707,"KCNQ1-AS1","KCNQ1 antisense RNA 1",TRUE
+"220629_at",0.756313947022433,0.251408333929371,-1.17770875421752,-5.28580497462379,-0.58520502821173,"KCNQ1DN","KCNQ1 downstream neighbor (non-protein coding)",TRUE
+"211486_s_at",0.579111490485788,0.0621749279656733,1.96418680136196,-4.21726074275714,0.572406221074052,"KCNQ2","potassium voltage-gated channel subfamily Q member 2",TRUE
+"210508_s_at",0.902960767180391,0.602631344331476,0.528170662198478,-5.80471611648739,0.453781857981584,"KCNQ2","potassium voltage-gated channel subfamily Q member 2",TRUE
+"205737_at",0.933859583363678,0.707010493856195,-0.380755984384741,-5.86931707656294,-0.276829010933934,"KCNQ2","potassium voltage-gated channel subfamily Q member 2",TRUE
+"1557042_at",0.689671882692226,0.158556529631037,1.45914973452173,-4.95268446189609,0.556019670631429,"KCNQ3","potassium voltage-gated channel subfamily Q member 3",TRUE
+"228579_at",0.839519981963042,0.428125192466463,0.807211974456285,-5.62720505112099,0.252279793889079,"KCNQ3","potassium voltage-gated channel subfamily Q member 3",TRUE
+"206573_at",0.895690630367785,0.576154269885828,-0.567388993661283,-5.78408792525144,-0.234305789429604,"KCNQ3","potassium voltage-gated channel subfamily Q member 3",TRUE
+"243209_at",0.731054546207485,0.213978074843732,1.27944158587167,-5.17235490850188,1.14788543495892,"KCNQ4","potassium voltage-gated channel subfamily Q member 4",TRUE
+"221083_at",0.820611742812032,0.38096477961307,0.893934433446391,-5.55778172623468,0.682927614981517,"KCNQ4","potassium voltage-gated channel subfamily Q member 4",TRUE
+"244623_at",0.69227042558579,0.16160968456047,1.44803949035245,-4.96695429696289,1.61126790092256,"KCNQ5","potassium voltage-gated channel subfamily Q member 5",TRUE
+"223891_at",0.947445977129843,0.760746700356237,0.308282952932784,-5.89349950795764,0.202623687224749,"KCNQ5","potassium voltage-gated channel subfamily Q member 5",TRUE
+"239098_at",0.735001929272204,0.220077120880023,1.26198600207674,-5.19239507257635,0.83264882320025,"KCNRG","potassium channel regulator",TRUE
+"240288_at",0.861763798017736,0.484069307244404,-0.711713021574733,-5.69593514440419,-0.434483501516564,"KCNRG///TRIM13","potassium channel regulator///tripartite motif containing 13",TRUE
+"207366_at",0.597654932724127,0.0743478331168111,1.87282225007555,-4.36204071224348,0.878335856692449,"KCNS1","potassium voltage-gated channel modifier subfamily S member 1",TRUE
+"1554680_s_at",0.579111490485788,0.0620902208927699,1.96487595472342,-4.21615068822118,0.899497389683468,"KCNS2","potassium voltage-gated channel modifier subfamily S member 2",TRUE
+"232401_at",0.955904644595647,0.800417363996845,0.255862609972681,-5.90784777098008,0.189320908388908,"KCNS2","potassium voltage-gated channel modifier subfamily S member 2",TRUE
+"1554212_s_at",0.996261754016157,0.981857145694696,-0.0229987448861902,-5.93942585575697,-0.0127069764353376,"KCNS2","potassium voltage-gated channel modifier subfamily S member 2",TRUE
+"205968_at",0.754513748034606,0.247951966791395,1.18660353319281,-5.27621086127349,1.27161752047601,"KCNS3","potassium voltage-gated channel modifier subfamily S member 3",TRUE
+"1569461_at",0.657015752622694,0.125825184090296,1.59078886910577,-4.7769901343397,0.665875488708611,"KCNT1","potassium sodium-activated channel subfamily T member 1",TRUE
+"1563608_a_at",0.899791165156338,0.591484120107616,0.544576578376135,-5.79626145927283,0.315271684676885,"KCNT1","potassium sodium-activated channel subfamily T member 1",TRUE
+"1569462_x_at",0.91671872326659,0.648084875977113,-0.462709357291829,-5.8359378892615,-0.272518369534018,"KCNT1","potassium sodium-activated channel subfamily T member 1",TRUE
+"234103_at",0.90261448949227,0.601883236856604,-0.529267058169649,-5.80415894313727,-0.402974623435516,"KCNT2","potassium sodium-activated channel subfamily T member 2",TRUE
+"244455_at",0.991754150288374,0.961774018575172,-0.048472438010974,-5.93853915309498,-0.0389597779683699,"KCNT2","potassium sodium-activated channel subfamily T member 2",TRUE
+"237273_at",0.651332373348922,0.120926838991585,1.61286832038553,-4.74635455933079,1.06663965458696,"KCNU1","potassium calcium-activated channel subfamily U member 1",TRUE
+"220294_at",0.872668627020452,0.51664697764452,-0.6590629646804,-5.73030678196693,-0.661165961300534,"KCNV1","potassium voltage-gated channel modifier subfamily V member 1",TRUE
+"215736_at",0.878252500971295,0.53027657177987,-0.63758741091287,-5.74359997232937,-0.511286428323245,"KCNV1","potassium voltage-gated channel modifier subfamily V member 1",TRUE
+"217522_at",0.726696341943087,0.206724394008168,1.30070855261176,-5.14762238213599,0.93925076702284,"KCNV2","potassium voltage-gated channel modifier subfamily V member 2",TRUE
+"242855_at",0.321883234796357,0.00717062240479127,2.96168285236388,-2.3852521527116,1.93845028465656,"KCP","kielin/chordin-like protein",TRUE
+"1556956_at",0.790887605610217,0.3208911894009,1.01536662979145,-5.44963699692048,0.44676503794501,"KCP","kielin/chordin-like protein",TRUE
+"1557621_at",0.853768202875953,0.462556605327993,0.747610400608584,-5.67105960591202,0.556308894348113,"KCP","kielin/chordin-like protein",TRUE
+"229183_at",0.713330901550199,0.187930587572524,-1.35864749916374,-5.07849860492051,-0.657251162390365,"KCTD1","potassium channel tetramerization domain containing 1",TRUE
+"226246_at",0.768852835478002,0.272964866905356,1.12418999820451,-5.34219280603413,0.47006342580926,"KCTD1","potassium channel tetramerization domain containing 1",TRUE
+"226245_at",0.858826390511142,0.475112493776745,0.726542637127667,-5.68579971895465,0.335144881338691,"KCTD1","potassium channel tetramerization domain containing 1",TRUE
+"236057_at",0.888750194607196,0.555275453311812,0.598958848977569,-5.76644328667214,0.329266705792257,"KCTD1","potassium channel tetramerization domain containing 1",TRUE
+"226518_at",0.843257017684317,0.43775334125165,-0.790259024602422,-5.64000136923956,-0.273904577847469,"KCTD10","potassium channel tetramerization domain containing 10",TRUE
+"223208_at",0.855289633438347,0.467751406704942,-0.738853402787842,-5.67723500175583,-0.24483521445123,"KCTD10","potassium channel tetramerization domain containing 10",TRUE
+"235857_at",0.617775129514679,0.0884056734838249,1.78233021588636,-4.50060959550598,0.885814604063088,"KCTD11","potassium channel tetramerization domain containing 11",TRUE
+"212188_at",0.62952950109137,0.100329631428354,1.71483957474242,-4.60068663750526,1.80600740123885,"KCTD12","potassium channel tetramerization domain containing 12",TRUE
+"212192_at",0.63277267773278,0.103546724237315,1.69780896515256,-4.62548524520082,2.18918119908816,"KCTD12","potassium channel tetramerization domain containing 12",TRUE
+"45653_at",0.493519901382617,0.0298925358372776,-2.32071795221988,-3.61002361703812,-0.899294074621187,"KCTD13","potassium channel tetramerization domain containing 13",TRUE
+"221889_at",0.724317760087277,0.201576292691901,-1.31615597903129,-5.12944110921138,-0.493504148480319,"KCTD13","potassium channel tetramerization domain containing 13",TRUE
+"222668_at",0.117874145553551,0.000643545943852332,-3.96887809985081,-0.267794304898049,-5.10676787343853,"KCTD15","potassium channel tetramerization domain containing 15",TRUE
+"222664_at",0.218155630903764,0.00263773598539271,-3.38630703002144,-1.5105497091646,-3.65406558488478,"KCTD15","potassium channel tetramerization domain containing 15",TRUE
+"218553_s_at",0.27101318038741,0.0042524813707642,-3.18523968424287,-1.92932303233976,-2.22292038164922,"KCTD15","potassium channel tetramerization domain containing 15",TRUE
+"228683_s_at",0.39657361496013,0.0137193437000827,-2.67702288234766,-2.94667204056077,-2.5425742774562,"KCTD15","potassium channel tetramerization domain containing 15",TRUE
+"229683_s_at",0.700633137129073,0.17242110050205,1.4100086792,-5.01512517048197,1.02935281434583,"KCTD15","potassium channel tetramerization domain containing 15",TRUE
+"233234_at",0.636147339487472,0.107303292528855,-1.67848205343106,-4.65340164150345,-1.12525384784569,"KCTD16","potassium channel tetramerization domain containing 16",TRUE
+"237384_x_at",0.676294804179428,0.142932074307014,1.51888824659008,-4.87445092170204,1.35608285478244,"KCTD16","potassium channel tetramerization domain containing 16",TRUE
+"205561_at",0.83872852514497,0.424148490555433,-0.814283078362421,-5.62179231444607,-0.769232309570413,"KCTD17","potassium channel tetramerization domain containing 17",TRUE
+"1554566_at",0.899998627338565,0.59426547706542,0.5404691175963,-5.79840180369147,0.313559049230889,"KCTD17","potassium channel tetramerization domain containing 17",TRUE
+"226493_at",0.459387394115312,0.0230027237164753,-2.44275071759432,-3.38848348195607,-0.84050667856541,"KCTD18","potassium channel tetramerization domain containing 18",TRUE
+"1553136_at",0.697412165374288,0.167798248549376,1.4260290030125,-4.9949613925712,1.14883826705072,"KCTD18","potassium channel tetramerization domain containing 18",TRUE
+"244538_at",0.705100208997726,0.176899724105408,1.3948123506492,-5.03407837404444,0.513711930723651,"KCTD19","potassium channel tetramerization domain containing 19",TRUE
+"34858_at",0.801917957653237,0.339626059185424,-0.975948124458321,-5.48612002711714,-0.352095202700809,"KCTD2","potassium channel tetramerization domain containing 2",TRUE
+"212564_at",0.932780653113734,0.70310880071506,-0.38609506662732,-5.8673369411655,-0.174593655755347,"KCTD2","potassium channel tetramerization domain containing 2",TRUE
+"228299_at",0.839519981963042,0.426296445328147,-0.81045862081748,-5.62472533252866,-0.291800089403772,"KCTD20","potassium channel tetramerization domain containing 20",TRUE
+"214849_at",0.843121215318579,0.437528637260797,0.790652038736305,-5.63970760965489,0.252598979203418,"KCTD20","potassium channel tetramerization domain containing 20",TRUE
+"223176_at",0.921294973929502,0.664323422812566,-0.439826073125367,-5.84589929730871,-0.174393306954036,"KCTD20","potassium channel tetramerization domain containing 20",TRUE
+"229873_at",0.605913415325856,0.0793424486500613,-1.83909094236517,-4.41426743439998,-1.05690482124789,"KCTD21","potassium channel tetramerization domain containing 21",TRUE
+"217894_at",0.606138724709726,0.0798198711647529,-1.8359642082072,-4.41907435270348,-0.901270505419074,"KCTD3","potassium channel tetramerization domain containing 3",TRUE
+"239787_at",0.85492369444809,0.466952564793602,0.740196258458586,-5.67629250443319,0.58231049174544,"KCTD4","potassium channel tetramerization domain containing 4",TRUE
+"240512_x_at",0.897949253801113,0.586721306683997,0.551632340131702,-5.79254804464403,0.762188921476977,"KCTD4","potassium channel tetramerization domain containing 4",TRUE
+"218474_s_at",0.688325162728721,0.157719938521544,-1.46222420941261,-4.94872000607077,-0.420395559305405,"KCTD5","potassium channel tetramerization domain containing 5",TRUE
+"222645_s_at",0.778413223654647,0.298338346624291,-1.06501459243121,-5.40183203421416,-0.316444850859819,"KCTD5","potassium channel tetramerization domain containing 5",TRUE
+"229837_s_at",0.942303845415102,0.74048317300905,0.335393495230961,-5.88504236192887,0.209360237437165,"KCTD5","potassium channel tetramerization domain containing 5",TRUE
+"238001_at",0.527546822913581,0.0402176943901371,-2.17930352342226,-3.85843315442794,-1.24035640565616,"KCTD6","potassium channel tetramerization domain containing 6",TRUE
+"238077_at",0.545412722791443,0.0470819621144274,-2.10260850616629,-3.98912438698695,-1.54716679723914,"KCTD6","potassium channel tetramerization domain containing 6",TRUE
+"1555569_a_at",0.78969417320323,0.317692259736027,1.02225597898423,-5.44312635532793,0.419890693527394,"KCTD7///RABGEF1","potassium channel tetramerization domain containing 7///RAB guanine nucleotide exchange factor 1",TRUE
+"1553717_at",0.9116561917482,0.630630033914822,-0.487589974501112,-5.82454588174126,-0.368054725454663,"KCTD7///RABGEF1","potassium channel tetramerization domain containing 7///RAB guanine nucleotide exchange factor 1",TRUE
+"218310_at",0.926735112907652,0.680813625274919,0.416829779288021,-5.85541018935106,0.135618854380526,"KCTD7///RABGEF1","potassium channel tetramerization domain containing 7///RAB guanine nucleotide exchange factor 1",TRUE
+"213474_at",0.949740807420078,0.772499239966714,0.292667923452634,-5.89805022124218,0.134821130178232,"KCTD7///RABGEF1","potassium channel tetramerization domain containing 7///RAB guanine nucleotide exchange factor 1",TRUE
+"218823_s_at",0.721046612088315,0.19720461472637,-1.3295168960473,-5.11356952363346,-0.964313510278618,"KCTD9","potassium channel tetramerization domain containing 9",TRUE
+"219479_at",0.925091998149497,0.675688248195838,0.42395230688905,-5.85251806475431,0.260176830614913,"KDELC1","KDEL motif containing 1",TRUE
+"225128_at",0.829030239823335,0.400065735370998,0.858024408698436,-5.58732862925194,0.698901345597722,"KDELC2","KDEL motif containing 2",TRUE
+"1555575_a_at",0.90934735616805,0.623528712990219,-0.49780150445539,-5.81970160479118,-0.129830585840313,"KDELR1","KDEL endoplasmic reticulum protein retention receptor 1",TRUE
+"200922_at",0.930827859648584,0.693477234045055,-0.399324370744139,-5.86231345428836,-0.146524499301266,"KDELR1","KDEL endoplasmic reticulum protein retention receptor 1",TRUE
+"200700_s_at",0.758081075834994,0.254858779722376,1.16891969479315,-5.29522307637786,0.400070298397642,"KDELR2","KDEL endoplasmic reticulum protein retention receptor 2",TRUE
+"200699_at",0.774230543658252,0.287146903238821,1.09064834189279,-5.37634983193776,0.376287811428037,"KDELR2","KDEL endoplasmic reticulum protein retention receptor 2",TRUE
+"200698_at",0.938372854572834,0.726189889761056,0.354670595550768,-5.87860024240415,0.0992890906567805,"KDELR2","KDEL endoplasmic reticulum protein retention receptor 2",TRUE
+"207265_s_at",0.620912785033482,0.0909990698943446,1.76701456103956,-4.52356966742553,0.905206868999926,"KDELR3","KDEL endoplasmic reticulum protein retention receptor 3",TRUE
+"204017_at",0.679594284947055,0.146928793691536,1.5031188657916,-4.89534732877197,0.967448927824453,"KDELR3","KDEL endoplasmic reticulum protein retention receptor 3",TRUE
+"207264_at",0.872668627020452,0.51632692530593,0.659570981567092,-5.72998720817148,0.575486628247582,"KDELR3","KDEL endoplasmic reticulum protein retention receptor 3",TRUE
+"236058_at",0.893600768892136,0.568601021859526,0.578741121439007,-5.77784958712611,0.789966334398255,"KDF1","keratinocyte differentiation factor 1",TRUE
+"212348_s_at",0.185392143728903,0.00180451794280855,3.54443312438397,-1.17671148085295,1.13581467020774,"KDM1A","lysine demethylase 1A",TRUE
+"1553150_at",0.671298718565642,0.137425423602119,1.54121869704385,-4.84456341227049,0.694110241813256,"KDM1B","lysine demethylase 1B",TRUE
+"227021_at",0.736116063927188,0.221414066581832,1.25820938152099,-5.19669989010294,0.461929958138334,"KDM1B","lysine demethylase 1B",TRUE
+"208989_s_at",0.89316156038085,0.567262479226274,0.580760871608134,-5.77672713351696,0.360958049758676,"KDM2A","lysine demethylase 2A",TRUE
+"208987_s_at",0.907964244160782,0.618212801415152,0.505480867068961,-5.81599399794463,0.266615029928085,"KDM2A","lysine demethylase 2A",TRUE
+"208988_at",0.932742319779223,0.702958200625225,0.386301376191341,-5.86725988051997,0.202994618791331,"KDM2A","lysine demethylase 2A",TRUE
+"226215_s_at",0.804537788156734,0.343384197653146,0.96822241463979,-5.49311624538154,0.362764381367406,"KDM2B","lysine demethylase 2B",TRUE
+"212689_s_at",0.793816937298172,0.325657318767225,-1.00519045957718,-5.45918086321455,-0.371760798539388,"KDM3A","lysine demethylase 3A",TRUE
+"242758_x_at",0.998038817582822,0.990937213972339,-0.0114876242017251,-5.93961920541919,-0.00941339644909078,"KDM3A","lysine demethylase 3A",TRUE
+"210878_s_at",0.772975577977561,0.283475211283048,-1.09921478502614,-5.36771361654116,-0.310199738382943,"KDM3B","lysine demethylase 3B",TRUE
+"201643_x_at",0.944850801239076,0.752107154708326,-0.319811772856427,-5.88998928757076,-0.0926515702483908,"KDM3B","lysine demethylase 3B",TRUE
+"203204_s_at",0.843954723626992,0.440199374639132,0.785988832588789,-5.64318427166201,0.26685821066412,"KDM4A","lysine demethylase 4A",TRUE
+"203205_at",0.89085645983207,0.559917149852134,-0.59188821309347,-5.77047540723003,-0.162039468729111,"KDM4A","lysine demethylase 4A",TRUE
+"212496_s_at",0.398650588126476,0.0139932246367644,-2.66819988060254,-2.96367022615552,-1.63032225542182,"KDM4B","lysine demethylase 4B",TRUE
+"212492_s_at",0.456898036702485,0.0224230095743194,-2.45451184967977,-3.36680324268661,-1.61434233167,"KDM4B","lysine demethylase 4B",TRUE
+"215616_s_at",0.561084367279569,0.0546794994062697,-2.0286570655425,-4.11228313303452,-1.26194028731645,"KDM4B","lysine demethylase 4B",TRUE
+"212495_at",0.57460012602512,0.0605513200677406,-1.97754305662157,-4.1957000993945,-1.17269309452785,"KDM4B","lysine demethylase 4B",TRUE
+"230126_s_at",0.758920166935337,0.256332486928118,-1.16519278805527,-5.29919807542881,-0.800272897634007,"KDM4B","lysine demethylase 4B",TRUE
+"216023_at",0.808257777979515,0.350504872999214,0.953740943504608,-5.50609341155339,0.420602441639854,"KDM4B","lysine demethylase 4B",TRUE
+"1559073_at",0.845588139978284,0.443099358017818,0.780944954363412,-5.64692293114055,0.49299109162553,"KDM4B","lysine demethylase 4B",TRUE
+"244385_at",0.682539393883246,0.15047699778452,1.48941025993901,-4.91337088105202,1.94780048437435,"KDM4C","lysine demethylase 4C",TRUE
+"1556493_a_at",0.9114480626414,0.629736845255446,0.488871449553421,-5.8239433417566,0.467837695721563,"KDM4C","lysine demethylase 4C",TRUE
+"214861_at",0.985236171081115,0.926465570314279,-0.0933486337985428,-5.93544011956212,-0.0617681218978179,"KDM4C","lysine demethylase 4C",TRUE
+"209984_at",0.994098505325585,0.972748257110379,0.034549604881865,-5.93910210229493,0.0152118701566017,"KDM4C","lysine demethylase 4C",TRUE
+"220278_at",0.833430578034454,0.410885895328178,0.838170924682424,-5.60317992582397,0.586985409144896,"KDM4D","lysine demethylase 4D",TRUE
+"242788_at",0.978378450271268,0.896062710658201,0.132144465439059,-5.9311818839051,0.0668276216611261,"KDM4D","lysine demethylase 4D",TRUE
+"226371_at",0.866000645572812,0.49657279837333,0.691274443819317,-5.70957761040995,0.220256004233969,"KDM5A","lysine demethylase 5A",TRUE
+"226367_at",0.883952384679702,0.542513145318922,-0.618560855899006,-5.75502337285856,-0.50183806830082,"KDM5A","lysine demethylase 5A",TRUE
+"230226_s_at",0.890498360630664,0.55919213498187,0.592990605553422,-5.76984979883351,0.196505733618723,"KDM5A","lysine demethylase 5A",TRUE
+"202040_s_at",0.93565329131222,0.71349920411134,0.371901629106244,-5.87254099155443,0.15763376580548,"KDM5A","lysine demethylase 5A",TRUE
+"215698_at",0.953931868692178,0.787430141896671,0.272936013129121,-5.90346515938774,0.102259147227395,"KDM5A","lysine demethylase 5A",TRUE
+"211202_s_at",0.845444642968895,0.44244214012716,-0.782086265143242,-5.64607894625594,-0.431388485029487,"KDM5B","lysine demethylase 5B",TRUE
+"201549_x_at",0.845588139978284,0.443128472318952,-0.780894419015575,-5.64696027452952,-0.441663242829549,"KDM5B","lysine demethylase 5B",TRUE
+"201547_at",0.852994610926182,0.459170555388403,0.753349927759841,-5.66697472529468,0.548008866397163,"KDM5B","lysine demethylase 5B",TRUE
+"201548_s_at",0.855405088766616,0.468126980120182,-0.738222532235396,-5.67767722438176,-0.40291079285786,"KDM5B","lysine demethylase 5B",TRUE
+"235285_at",0.872699520348127,0.516931809163136,-0.658611000143646,-5.73059089691869,-0.206191334644574,"KDM5B","lysine demethylase 5B",TRUE
+"239207_at",0.680708651141727,0.148426382620973,-1.49730028908844,-4.90301356202826,-0.584579380469695,"KDM5C","lysine demethylase 5C",TRUE
+"202383_at",0.804065713196639,0.34271676316258,-0.969590241270608,-5.49188127107144,-0.242104676917055,"KDM5C","lysine demethylase 5C",TRUE
+"206700_s_at",0.717937808890208,0.19379566761657,1.34009715686737,-5.10090545176231,0.790989343047323,"KDM5D","lysine demethylase 5D",TRUE
+"203992_s_at",0.330603887678364,0.00801793790693206,-2.9133006087818,-2.48232315149715,-1.17024555040236,"KDM6A","lysine demethylase 6A",TRUE
+"203991_s_at",0.358427723880268,0.0101882004027434,-2.80870747118381,-2.68996019729815,-1.09057424706667,"KDM6A","lysine demethylase 6A",TRUE
+"203990_s_at",0.446720401893991,0.0209735943605281,-2.48520116480523,-3.30996977926573,-1.10213464632689,"KDM6A","lysine demethylase 6A",TRUE
+"238220_at",0.823073978212882,0.38900235574135,-0.87868428306201,-5.57046694650212,-0.81934732166623,"KDM6A","lysine demethylase 6A",TRUE
+"41387_r_at",0.466373536852322,0.024404109536982,-2.41541723196083,-3.4386513105449,-0.933344089278064,"KDM6B","lysine demethylase 6B",TRUE
+"1556066_at",0.718706241731185,0.194710153037521,-1.33724466839778,-5.10432804776785,-1.19922923357095,"KDM6B","lysine demethylase 6B",TRUE
+"213146_at",0.766550448794594,0.267665419628845,-1.13704983568483,-5.32885427925412,-0.510399546654281,"KDM6B","lysine demethylase 6B",TRUE
+"41386_i_at",0.890791272165577,0.559550140442086,-0.592446162043901,-5.7701589115005,-0.183044819205339,"KDM6B","lysine demethylase 6B",TRUE
+"1556067_a_at",0.899808883319249,0.592511849517834,-0.54305774473425,-5.79705473895008,-0.565035174787636,"KDM6B","lysine demethylase 6B",TRUE
+"221778_at",0.421194407365884,0.0175255051917472,-2.56699798474176,-3.15670192497344,-1.45126682283625,"KDM7A","lysine demethylase 7A",TRUE
+"225142_at",0.552986220491716,0.0504285437840797,-2.06880832257836,-4.04577127669556,-1.36609256361539,"KDM7A","lysine demethylase 7A",TRUE
+"237229_at",0.471611371152717,0.0256816398112577,-2.39173728811808,-3.48186292857575,-1.80105813295413,"KDM8","lysine demethylase 8",TRUE
+"220070_at",0.749700870305823,0.242591820712403,1.20058292062292,-5.26100531346874,0.797396575118236,"KDM8","lysine demethylase 8",TRUE
+"241045_at",0.844298618270301,0.44105820091516,0.784492980053957,-5.6442954037949,0.326432920203414,"KDM8","lysine demethylase 8",TRUE
+"203934_at",0.275944828889054,0.00443126766830525,3.16776794215679,-1.96535476287105,1.72645624153068,"KDR","kinase insert domain receptor",TRUE
+"222359_x_at",0.118233429487257,0.000653068051305927,3.96286652785243,-0.280751978184815,2.42380756101625,"KDSR","3-ketodihydrosphingosine reductase",TRUE
+"1558279_a_at",0.872701172251,0.51695958069787,0.658566940247948,-5.73061858395022,0.339143692913947,"KDSR","3-ketodihydrosphingosine reductase",TRUE
+"229850_at",0.897011777275924,0.582342118205357,0.558144860578352,-5.78907934656125,0.28848200765176,"KDSR","3-ketodihydrosphingosine reductase",TRUE
+"202419_at",0.907189812622248,0.616149906729832,0.508469213148345,-5.81453625271675,0.229943077750896,"KDSR","3-ketodihydrosphingosine reductase",TRUE
+"202417_at",0.497725944448536,0.0308100486234244,2.30647332787153,-3.63546301565963,1.0943987468162,"KEAP1","kelch like ECH associated protein 1",TRUE
+"206077_at",0.624520459874487,0.096071252251207,1.73811295918117,-4.56649919563726,0.997339720029655,"KEL","Kell blood group, metallo-endopeptidase",TRUE
+"220504_at",0.599760956786526,0.0762713842256373,1.85960426606298,-4.3825865772956,1.6917096934486,"KERA","keratocan",TRUE
+"230055_at",0.488294327273387,0.0289691945149836,2.33546427741784,-3.58359325776906,1.59700127255138,"KHDC1","KH homology domain containing 1",TRUE
+"241024_at",0.571390900668275,0.0592240006234497,1.9886996188781,-4.17761467131236,2.01349496334338,"KHDC1","KH homology domain containing 1",TRUE
+"220513_at",0.0681210092794308,0.000168871564723419,4.51500249654052,0.911447317837264,3.10817212432951,"KHDC1L","KH domain containing 1 like",TRUE
+"231474_at",0.963875783795895,0.834847766208293,0.210958576995377,-5.91803067304292,0.168618620846732,"KHDC3L","KH domain containing 3 like, subcortical maternal complex member",TRUE
+"214185_at",0.935873745908989,0.713882952846462,-0.371378928021669,-5.87272897029275,-0.12806952187454,"KHDRBS1","KH RNA binding domain containing, signal transduction associated 1",TRUE
+"201488_x_at",0.936318756756998,0.715844232009213,0.368709126733969,-5.87368503985617,0.0862337071229877,"KHDRBS1","KH RNA binding domain containing, signal transduction associated 1",TRUE
+"200040_at",0.968451827985008,0.85181942293292,0.188992174434463,-5.92230149835255,0.0388553372835929,"KHDRBS1","KH RNA binding domain containing, signal transduction associated 1",TRUE
+"215527_at",0.812302873476553,0.357238587304106,0.940228786852924,-5.5180403925866,0.583761001268233,"KHDRBS2","KH RNA binding domain containing, signal transduction associated 2",TRUE
+"209781_s_at",0.835288731225683,0.414359508443518,0.831867997489793,-5.6081397941589,0.767384468332085,"KHDRBS3","KH RNA binding domain containing, signal transduction associated 3",TRUE
+"230249_at",0.956398858120188,0.802132095162409,0.253614279570772,-5.90840394841688,0.208418788932017,"KHDRBS3","KH RNA binding domain containing, signal transduction associated 3",TRUE
+"205175_s_at",0.896115372949367,0.577240281828369,0.565762986127954,-5.78497165966499,0.256146215229027,"KHK","ketohexokinase",TRUE
+"211028_s_at",0.986720888319514,0.938023151259186,-0.0786421938101087,-5.93667164160448,-0.0637937611358614,"KHK","ketohexokinase",TRUE
+"212356_at",0.769017612409316,0.274383522801289,1.12077847520409,-5.34570880842062,0.920901612520023,"KHNYN","KH and NYN domain containing",TRUE
+"212355_at",0.97922824128613,0.898893710755752,-0.128524100694057,-5.9316411567022,-0.0609361370255765,"KHNYN","KH and NYN domain containing",TRUE
+"204371_s_at",0.673366993714442,0.139535089057056,1.53257815641836,-4.85616917580629,0.548531259556833,"KHSRP","KH-type splicing regulatory protein",TRUE
+"204372_s_at",0.737488397392592,0.223620486935054,1.25201466777853,-5.20373704064457,0.429211410848977,"KHSRP","KH-type splicing regulatory protein",TRUE
+"212303_x_at",0.740409348583556,0.22899537420298,1.23711723105517,-5.22053820473083,0.543368838151308,"KHSRP","KH-type splicing regulatory protein",TRUE
+"227555_s_at",0.822819707575556,0.388015259921464,0.880546010491314,-5.56892918849943,0.275335235494001,"KHSRP","KH-type splicing regulatory protein",TRUE
+"203144_s_at",0.842038788192302,0.435171228407907,-0.794782729804305,-5.63661179871822,-0.826903568717643,"KIAA0040","KIAA0040",TRUE
+"203143_s_at",0.989143455305063,0.947128154627066,-0.0670692026379602,-5.93749277289269,-0.0730787445761631,"KIAA0040","KIAA0040",TRUE
+"207161_at",0.984161165881616,0.922743327951637,0.0980893337808931,-5.93499828067641,0.0862668443833607,"KIAA0087","KIAA0087",TRUE
+"201729_s_at",0.855439520086837,0.468517185439753,-0.737567400981781,-5.6781360737793,-0.239928281117558,"KIAA0100","KIAA0100",TRUE
+"201728_s_at",0.900692252557887,0.596054666407317,0.537831840268948,-5.79976774951696,0.169269585174087,"KIAA0100","KIAA0100",TRUE
+"202503_s_at",0.248692078473507,0.00343910457799316,-3.27495097705321,-1.74337009120511,-1.01005120703655,"KIAA0101","KIAA0101",TRUE
+"211713_x_at",0.494126560803849,0.0300045758000691,-2.31895716272174,-3.61317310383595,-0.972146401065693,"KIAA0101","KIAA0101",TRUE
+"227056_at",0.678126513742682,0.145425088528323,-1.50901017455319,-4.88756100728523,-0.633813222670463,"KIAA0141","KIAA0141",TRUE
+"201978_s_at",0.91339551560427,0.636979563136263,-0.478503843946618,-5.82877376354627,-0.185895401778321,"KIAA0141","KIAA0141",TRUE
+"238659_at",0.914777625972484,0.641132239593496,0.472583467654186,-5.83148672490626,0.361155447623896,"KIAA0141","KIAA0141",TRUE
+"201977_s_at",0.983051865094694,0.917577569026023,0.104672358711645,-5.93434847823796,0.0323444821897763,"KIAA0141","KIAA0141",TRUE
+"201985_at",0.954724542854807,0.794256995430788,-0.2639512164082,-5.90580652924534,-0.138582368479144,"KIAA0196","KIAA0196",TRUE
+"44790_s_at",0.694526899259872,0.164073549805704,1.43919647426649,-4.97824863332381,1.49098130727472,"KIAA0226L","KIAA0226 like",TRUE
+"219471_at",0.985736911886368,0.931171232870062,0.08735855726499,-5.93596713339581,0.0612613708094605,"KIAA0226L","KIAA0226 like",TRUE
+"232366_at",0.134242602708516,0.000849527947638712,-3.85509373322516,-0.512754170699903,-1.69374708767834,"KIAA0232","KIAA0232",TRUE
+"212441_at",0.384135218769668,0.0123467810485553,-2.72390955117937,-2.8559056500408,-1.24036093138085,"KIAA0232","KIAA0232",TRUE
+"206017_at",0.717276855910507,0.193018644371491,1.34252918025192,-5.09798252396346,1.08034241986376,"KIAA0319","KIAA0319",TRUE
+"217929_s_at",0.362885168249175,0.0105120808835308,-2.79495459413741,-2.71702493373599,-2.11481770219541,"KIAA0319L","KIAA0319 like",TRUE
+"222468_at",0.470885186348082,0.0255693222372232,-2.39377499016988,-3.47815374623268,-0.993153184933401,"KIAA0319L","KIAA0319 like",TRUE
+"203288_at",0.946964932481069,0.759286614998401,0.310228291380194,-5.89291615677411,0.10376699701454,"KIAA0355","KIAA0355",TRUE
+"236368_at",0.626839388794963,0.0973655189596358,1.73094776144403,-4.5770610540896,0.524120555753031,"KIAA0368","KIAA0368",TRUE
+"212428_at",0.969577323811311,0.854806323542325,0.185136371073613,-5.92300293580212,0.0601730653557162,"KIAA0368","KIAA0368",TRUE
+"214356_s_at",0.982243328340126,0.914722142178571,-0.108313209550201,-5.93397099217951,-0.0384526094549642,"KIAA0368","KIAA0368",TRUE
+"212427_at",0.993225426079816,0.96805573962705,-0.0405019026968953,-5.93888453196652,-0.0166806175530523,"KIAA0368","KIAA0368",TRUE
+"202714_s_at",0.712948021516228,0.187051316119342,-1.36146766113657,-5.07506960529152,-0.421583582643988,"KIAA0391","KIAA0391",TRUE
+"202713_s_at",0.62952950109137,0.100320920848335,-1.71488631372699,-4.60061832487322,-0.606069088232729,"KIAA0391///PSMA6","KIAA0391///proteasome subunit alpha 6",TRUE
+"208805_at",0.959357995170594,0.816227519030411,-0.235181956547116,-5.91277959948847,-0.0618343369319767,"KIAA0391///PSMA6","KIAA0391///proteasome subunit alpha 6",TRUE
+"205496_at",0.643515428391208,0.113868538403886,1.64603819117946,-4.69971850537338,0.805921827221787,"KIAA0408","KIAA0408",TRUE
+"202386_s_at",0.797856706388872,0.331758905944903,0.992312868927785,-5.47113327582115,0.315468320889261,"KIAA0430","KIAA0430",TRUE
+"1558697_a_at",0.957896251169488,0.810537030893556,0.242612912894101,-5.91105504095444,0.0816918697596565,"KIAA0430","KIAA0430",TRUE
+"214294_at",0.70573152022539,0.178085910215443,1.39083894301634,-5.03900611265639,0.555629281340349,"KIAA0485","uncharacterized LOC57235",TRUE
+"214295_at",0.980933808596736,0.910353221435884,0.113886783127262,-5.93336814870473,0.0696315377407286,"KIAA0485","uncharacterized LOC57235",TRUE
+"215480_at",0.54295328972902,0.0458326128438688,2.11578212406063,-3.9668867872936,1.20568277361036,"KIAA0509","uncharacterized LOC57242",TRUE
+"204546_at",0.456898036702485,0.0224868215487218,-2.45320350945483,-3.36921777730926,-2.01263970610666,"KIAA0513","KIAA0513",TRUE
+"1554440_at",0.836756831475262,0.418688576539809,-0.824059400120539,-5.61423592254642,-0.711834611000711,"KIAA0513","KIAA0513",TRUE
+"213185_at",0.822356669023087,0.387150629367248,-0.882179296121521,-5.56757763381966,-0.273065002619607,"KIAA0556","KIAA0556",TRUE
+"205631_at",0.957228789717225,0.806400887581612,-0.248022872197111,-5.90976596001791,-0.0774255827385204,"KIAA0586","KIAA0586",TRUE
+"37232_at",0.976371465776674,0.886999464163387,-0.143747231571445,-5.929624174096,-0.0396525239791821,"KIAA0586","KIAA0586",TRUE
+"204711_at",0.426884347674613,0.0183568226205486,2.54598475529735,-3.19631817020118,0.908178138792705,"KIAA0753","KIAA0753",TRUE
+"215268_at",0.646392036827936,0.1173482599691,1.62947640954733,-4.72309533307933,1.82228512099583,"KIAA0754","KIAA0754",TRUE
+"239009_at",0.984801578023171,0.925362219391326,0.0947536434316038,-5.93531145069607,0.0696777417788068,"KIAA0754","KIAA0754",TRUE
+"1553868_a_at",0.508488499910913,0.0336383457658899,-2.26488686837333,-3.70920771449474,-3.07855796979211,"KIAA0825","KIAA0825",TRUE
+"233915_at",0.88113080359582,0.537382371692408,-0.626510274701781,-5.75029111927673,-0.441426341867875,"KIAA0825","KIAA0825",TRUE
+"213424_at",0.965602359950334,0.839168938919069,-0.205356041474136,-5.91916433926293,-0.151210064290753,"KIAA0895","KIAA0895",TRUE
+"1558041_a_at",0.80110325033185,0.337538200824384,-0.980265522522837,-5.48218821394313,-0.716865937773092,"KIAA0895L","KIAA0895 like",TRUE
+"202220_at",0.869438938525166,0.506508807862891,-0.675241228439772,-5.7200138134204,-0.187688013289572,"KIAA0907","KIAA0907",TRUE
+"230028_at",0.986418104647939,0.935992158557569,-0.081225148853357,-5.93647058048524,-0.0382157664796772,"KIAA0907","KIAA0907",TRUE
+"209760_at",0.635916735157933,0.107007261086052,-1.67998409573753,-4.65124070115777,-0.845746074933563,"KIAA0922","KIAA0922",TRUE
+"227144_at",0.702794018909517,0.174373020924394,1.40334739745751,-5.02345412471296,0.48846636401476,"KIAA0930","KIAA0930",TRUE
+"212421_at",0.729083413548563,0.211150537561972,1.28766431652215,-5.16283335357239,0.546885285722947,"KIAA0930","KIAA0930",TRUE
+"217118_s_at",0.798428326317339,0.332934659801147,0.989850274711866,-5.47340299997917,0.383453813060466,"KIAA0930","KIAA0930",TRUE
+"215081_at",0.87825255145971,0.530325001154865,-0.637511644149204,-5.74364612235889,-0.422574996987556,"KIAA1024","KIAA1024",TRUE
+"215936_s_at",0.730101539866086,0.212927078614054,1.28248812949212,-5.16883320490472,0.399111312479148,"KIAA1033","KIAA1033",TRUE
+"212794_s_at",0.73759219552868,0.224313169679759,1.25007954387205,-5.20592921792524,0.41205945706318,"KIAA1033","KIAA1033",TRUE
+"212795_at",0.86740290814944,0.499738300991447,0.686146871959553,-5.7129406613575,0.189940319839238,"KIAA1033","KIAA1033",TRUE
+"214098_at",0.535243600695458,0.0428349506686109,2.1487598713847,-3.91083324653146,0.920354954161697,"KIAA1107","KIAA1107",TRUE
+"1558293_at",0.74413941468137,0.234896765640837,1.22106373261283,-5.23844904301245,0.57456361606181,"KIAA1107","KIAA1107",TRUE
+"233227_at",0.612280302313181,0.08383418573536,1.81029660975748,-4.45831256840984,0.897377862595105,"KIAA1109","KIAA1109",TRUE
+"216294_s_at",0.734730148360473,0.219513180594494,1.26358430274088,-5.19056990729056,0.337036198281581,"KIAA1109","KIAA1109",TRUE
+"1553793_a_at",0.754513748034606,0.247788083157043,1.18702757379682,-5.2757519087458,0.348919791397322,"KIAA1109","KIAA1109",TRUE
+"212779_at",0.897699110987203,0.584977004927528,0.554223477438673,-5.7911726871424,0.225419782027325,"KIAA1109","KIAA1109",TRUE
+"1553792_at",0.931582451098271,0.697959141440648,0.393159430875252,-5.86467517545068,0.262787913407418,"KIAA1109","KIAA1109",TRUE
+"233096_at",0.984916798133038,0.925761810460506,-0.0942447808156421,-5.93535827346461,-0.0520314453540873,"KIAA1109","KIAA1109",TRUE
+"214929_s_at",0.991367768700244,0.959846426151342,0.0509188764176841,-5.93842073549602,0.0229993444591425,"KIAA1109","KIAA1109",TRUE
+"226816_s_at",0.901781358899845,0.599087817338755,-0.533369743221086,-5.80206403947668,-0.169523957353878,"KIAA1143","KIAA1143",TRUE
+"227493_s_at",0.915569510513076,0.644129094271382,-0.468321554796682,-5.83341924587893,-0.161518897229033,"KIAA1143","KIAA1143",TRUE
+"227502_at",0.743553048228796,0.234148349804121,-1.22308258774225,-5.23620772019137,-0.527663519509791,"KIAA1147","KIAA1147",TRUE
+"223161_at",0.912421110187259,0.633190094957364,-0.48392157890811,-5.82626218747889,-0.196317464195699,"KIAA1147","KIAA1147",TRUE
+"223162_s_at",0.975265330414469,0.88024730015077,-0.152404414033658,-5.92837674226676,-0.0532140597868587,"KIAA1147","KIAA1147",TRUE
+"232244_at",0.685154158710982,0.153776617917675,-1.47689640467511,-4.92970755589352,-1.03010333406334,"KIAA1161","KIAA1161",TRUE
+"231185_at",0.889731273564282,0.557955485627774,-0.594872656660196,-5.7687791335082,-0.456802176425374,"KIAA1161","KIAA1161",TRUE
+"224502_s_at",0.839045421044582,0.424806149004371,-0.813110828346569,-5.62269270236606,-0.217619577055352,"KIAA1191","KIAA1191",TRUE
+"232332_at",0.945966513604392,0.755581640525982,0.315170105917117,-5.8914179016757,0.162048735104765,"KIAA1210","KIAA1210",TRUE
+"227230_s_at",0.756601922352523,0.252062259088271,-1.17603619160126,-5.28760199658391,-1.0394737400335,"KIAA1211","KIAA1211",TRUE
+"227231_at",0.794620886196317,0.326690645863207,-1.00299789146291,-5.46122578589037,-0.67812427157798,"KIAA1211","KIAA1211",TRUE
+"1564828_at",0.95915232180739,0.814860675590132,0.236965605747653,-5.91237052045582,0.0950024487754737,"KIAA1211","KIAA1211",TRUE
+"214134_at",0.912329443373872,0.632738230740823,-0.484568579298755,-5.82596040034958,-0.21177679890115,"KIAA1211L","KIAA1211 like",TRUE
+"228067_at",0.93565329131222,0.713539256681349,-0.371847068890354,-5.87256062521302,-0.41806017647613,"KIAA1211L","KIAA1211 like",TRUE
+"229320_at",0.977111426276197,0.890775343965446,0.138910988772705,-5.93028935063151,0.0604855792610799,"KIAA1211L","KIAA1211 like",TRUE
+"232046_at",0.819018525257656,0.374267787291217,0.906803030430048,-5.54692042488814,0.395418363690364,"KIAA1217","KIAA1217",TRUE
+"237167_at",0.851651268366447,0.455782492973294,-0.75911829031172,-5.6628395337344,-0.257894664378349,"KIAA1217","KIAA1217",TRUE
+"1554438_at",0.897949253801113,0.586692087341293,-0.551675713601455,-5.79252507381166,-0.555627159048676,"KIAA1217","KIAA1217",TRUE
+"1560115_a_at",0.945509858471469,0.754453919578286,0.316675881942648,-5.89095672000429,0.243440865246573,"KIAA1217","KIAA1217",TRUE
+"1562966_at",0.950031925101785,0.773110787870208,0.291857453285407,-5.89828001640303,0.250761586986769,"KIAA1217","KIAA1217",TRUE
+"231807_at",0.975398143273847,0.881163114070415,0.151229533150504,-5.92855030128468,0.108455970060627,"KIAA1217","KIAA1217",TRUE
+"232762_at",0.996224607226304,0.981174190663543,-0.0238646598331792,-5.93940609139344,-0.0224242140417035,"KIAA1217","KIAA1217",TRUE
+"232250_at",0.869082033398093,0.50601389144027,0.676035623176611,-5.7195022472418,0.617789898888756,"KIAA1257","KIAA1257",TRUE
+"1554852_a_at",0.976040592791123,0.885014877516465,-0.146290541283213,-5.92926525298217,-0.073352582218968,"KIAA1257","KIAA1257",TRUE
+"226248_s_at",0.208781905890222,0.00240953603322781,-3.42411854813446,-1.43104154554906,-5.82185506472967,"KIAA1324","KIAA1324",TRUE
+"243349_at",0.459154397418224,0.0229766151136033,-2.44327445824947,-3.38751922208583,-3.60251465637648,"KIAA1324","KIAA1324",TRUE
+"221874_at",0.482262518773694,0.0274792662358463,-2.36019659602493,-3.53905045070663,-2.72372011428546,"KIAA1324","KIAA1324",TRUE
+"235301_at",0.85334340854827,0.460982414082347,0.750275601367862,-5.6691664343061,0.777745392259372,"KIAA1324L","KIAA1324 like",TRUE
+"244317_at",0.937623890519979,0.723885068438488,0.357791737926846,-5.8775237487825,0.206551347266146,"KIAA1324L","KIAA1324 like",TRUE
+"230890_at",0.73759219552868,0.224242438057453,1.25027693488762,-5.20570573968957,0.5585187533433,"KIAA1328","KIAA1328",TRUE
+"232358_at",0.836592953877091,0.418334729931407,0.824695739479776,-5.61374115001994,0.537353847984502,"KIAA1328","KIAA1328",TRUE
+"238818_at",0.563547120625998,0.0557174829369855,-2.01927725193113,-4.12769714088177,-0.961317112208823,"KIAA1429","KIAA1429",TRUE
+"223110_at",0.778686132916778,0.29956833867514,-1.06223956285698,-5.40455813082914,-0.404976859615592,"KIAA1429","KIAA1429",TRUE
+"243927_x_at",0.888830748858811,0.556063953008425,-0.597755573835026,-5.76713273630284,-0.324926513735099,"KIAA1429","KIAA1429",TRUE
+"238770_at",0.839088939498165,0.424934126713186,0.81288284496259,-5.62286767171257,0.437118274444404,"KIAA1456","KIAA1456",TRUE
+"231841_s_at",0.26033197578137,0.00386985891013819,3.22515401266614,-1.84677916990372,3.62125101214463,"KIAA1462","KIAA1462",TRUE
+"213316_at",0.384963213170922,0.0126121646324733,2.71447228541181,-2.87423311166345,2.43715979093492,"KIAA1462","KIAA1462",TRUE
+"231842_at",0.514646418668119,0.0347992283459723,2.24873729461604,-3.73763146388598,2.54675579255354,"KIAA1462","KIAA1462",TRUE
+"225508_at",0.717937808890208,0.193839537005759,-1.33996007740672,-5.10107006836951,-0.617257625049223,"KIAA1468","KIAA1468",TRUE
+"225506_at",0.775077055901587,0.291502688623764,-1.08058768487646,-5.38641553128782,-0.526426853696556,"KIAA1468","KIAA1468",TRUE
+"224746_at",0.950464890991424,0.774678864878844,0.289780227674856,-5.89886609278196,0.123588035087604,"KIAA1522","KIAA1522",TRUE
+"1553810_a_at",0.805746717966166,0.345957995162528,0.962964648257846,-5.49784851654046,0.359080663936817,"KIAA1524","KIAA1524",TRUE
+"231855_at",0.826140850652187,0.394035327675104,0.869239171319992,-5.57822190130924,0.438693119556403,"KIAA1524","KIAA1524",TRUE
+"232921_at",0.73223722457785,0.216391855112035,-1.27248811944082,-5.18036612375162,-0.947198118429117,"KIAA1549","KIAA1549",TRUE
+"223575_at",0.864894115958506,0.493234710087018,0.696701796191116,-5.70599189999067,0.241374932037452,"KIAA1549","KIAA1549",TRUE
+"238885_at",0.941250174875668,0.736989848860125,-0.340092645767617,-5.88350477770897,-0.115025942213951,"KIAA1549","KIAA1549",TRUE
+"206044_s_at",0.901781358899845,0.598765245464658,-0.533843759806802,-5.80182098392061,-0.220490388493152,"KIAA1549///BRAF","KIAA1549///B-Raf proto-oncogene, serine/threonine kinase",TRUE
+"235486_at",0.26392932766945,0.00399416211484794,3.21178284332313,-1.87446596305118,1.2300621256587,"KIAA1549L","KIAA1549 like",TRUE
+"214772_at",0.446963972064621,0.0210700337702237,2.48309886003638,-3.3138749674559,1.11584618708784,"KIAA1549L","KIAA1549 like",TRUE
+"244584_at",0.792305111661886,0.323234380362949,-1.01035061614929,-5.45435221773705,-0.512694396544808,"KIAA1549L","KIAA1549 like",TRUE
+"218614_at",0.83516820266233,0.414104426585758,-0.832329707018587,-5.60777765605898,-0.433083080972041,"KIAA1551","KIAA1551",TRUE
+"227152_at",0.941400961503247,0.738089346442793,-0.338612786221779,-5.88399127713804,-0.180895712878526,"KIAA1551","KIAA1551",TRUE
+"231869_at",0.893462835798285,0.568224677319801,0.579308748287896,-5.77753451729304,0.338836046532002,"KIAA1586","KIAA1586",TRUE
+"215367_at",0.869971289491322,0.507856838524954,-0.673079701406619,-5.72140285748906,-0.39184313040476,"KIAA1614","KIAA1614",TRUE
+"232320_at",0.951795728563606,0.778653335947353,0.284521064155716,-5.90033136590707,0.116082571148818,"KIAA1614-AS1","KIAA1614 antisense RNA 1",TRUE
+"52837_at",0.62110896023334,0.0917889419055398,1.76242441719046,-4.53042255678066,0.801036816823503,"KIAA1644","KIAA1644",TRUE
+"221901_at",0.675622576285316,0.141948786211526,1.52282319583863,-4.86920949339113,0.497613375435796,"KIAA1644","KIAA1644",TRUE
+"230880_at",0.75959865506602,0.257426131704426,-1.16243730249597,-5.30212983533281,-0.912236582497272,"KIAA1652","KIAA1652 protein",TRUE
+"1560671_at",0.899808883319249,0.592301841202866,-0.543368001149398,-5.79689286848067,-0.322319955725162,"KIAA1652","KIAA1652 protein",TRUE
+"215681_at",0.588653540532996,0.067340754095222,1.92364820004774,-4.2820888242447,1.51696695751925,"KIAA1654","KIAA1654 protein",TRUE
+"215680_at",0.697172073261335,0.166854681783049,1.42934228942882,-4.99076785269819,0.888829904467418,"KIAA1654","KIAA1654 protein",TRUE
+"1569365_a_at",0.757950630724418,0.25421019753386,-1.17056499167286,-5.29346471944253,-0.860527640988993,"KIAA1656","KIAA1656 protein",TRUE
+"232933_at",0.804065713196639,0.342726649546713,-0.969569967046071,-5.49189958775061,-0.65907466647814,"KIAA1656","KIAA1656 protein",TRUE
+"215943_at",0.964685626382167,0.836766788703561,-0.208469662614092,-5.91853805274601,-0.19744768937714,"KIAA1661","KIAA1661 protein",TRUE
+"1565618_at",0.505067985736837,0.0328757795103992,2.27577464296725,-3.68997683758291,0.51490216866375,"KIAA1671","KIAA1671",TRUE
+"225525_at",0.953983577550391,0.788578408280529,-0.271423198077343,-5.90386483565955,-0.138187915848102,"KIAA1671","KIAA1671",TRUE
+"1563478_at",0.954577684533304,0.792883093236152,0.265757596472142,-5.90534205100556,0.214955781403901,"KIAA1671","KIAA1671",TRUE
+"232433_at",0.932249295738588,0.70095201300255,-0.389051318949593,-5.86622884853319,-0.204698806319733,"KIAA1683","KIAA1683",TRUE
+"223600_s_at",0.971094654049796,0.861505244853368,-0.176499044520954,-5.92452191295952,-0.126506333087829,"KIAA1683","KIAA1683",TRUE
+"1561394_s_at",0.62110896023334,0.0912501904303182,1.76555153890462,-4.52575531865348,1.15001699124547,"KIAA1755","KIAA1755",TRUE
+"231893_at",0.774011928861764,0.285798980432454,1.09378394313963,-5.37319566992357,0.681222280840505,"KIAA1755","KIAA1755",TRUE
+"1561393_at",0.881212599079924,0.537882177761212,0.625734113023433,-5.75075572852606,0.349519840111989,"KIAA1755","KIAA1755",TRUE
+"228565_at",0.6708432030569,0.136486887118713,1.54509781094588,-4.83933627370045,1.10401560767993,"KIAA1804","mixed lineage kinase 4",TRUE
+"243539_at",0.607377668936197,0.0809729090638015,1.82847917330769,-4.43055775472308,1.3922604906189,"KIAA1841","KIAA1841",TRUE
+"244673_at",0.99694109019133,0.984523771811444,-0.019617910490008,-5.93949603019647,-0.0167991366092766,"KIAA1841","KIAA1841",TRUE
+"230166_at",0.812302873476553,0.359208834635017,-0.936307712917865,-5.52147798848716,-0.519292931809168,"KIAA1958","KIAA1958",TRUE
+"235112_at",0.956960361976289,0.804980929867563,-0.249881874592085,-5.90931647438913,-0.106913003600475,"KIAA1958","KIAA1958",TRUE
+"228349_at",0.974884920935236,0.877054206243826,-0.156502505364711,-5.92776086336809,-0.0567704313642272,"KIAA1958","KIAA1958",TRUE
+"1564193_at",0.896115372949367,0.577694092966567,0.565083983878398,-5.78533996928127,0.215182246153377,"KIAA2012","KIAA2012",TRUE
+"1555933_at",0.859947009633611,0.478374207757902,-0.721123548827171,-5.68952648861126,-0.244794682324112,"KIAA2013","KIAA2013",TRUE
+"224708_at",0.955736115035547,0.798046211172069,0.25897385544908,-5.90707008611137,0.0778984459095682,"KIAA2013","KIAA2013",TRUE
+"244370_at",0.522667179791589,0.0383059813626266,-2.20277303696093,-3.81785900118368,-2.84559217387316,"KIAA2022","KIAA2022",TRUE
+"234333_at",0.937232018318296,0.721501558811251,0.361023252732066,-5.87639937187121,0.258920464646891,"KIAA2022","KIAA2022",TRUE
+"244076_at",0.993461753950386,0.969095366898764,-0.0391830495015166,-5.93893571485499,-0.0219700052105489,"KIAA2022","KIAA2022",TRUE
+"236306_at",0.8920930097751,0.563524511375681,-0.586414132078396,-5.77356527831457,-0.518221002718319,"KIAA2026","KIAA2026",TRUE
+"238490_at",0.895690630367785,0.576247407148725,0.567249485401682,-5.78416384435822,0.217025863717508,"KIAA2026","KIAA2026",TRUE
+"228446_at",0.978257169730337,0.895142489814682,-0.13332165768549,-5.93102980355815,-0.0764291796974614,"KIAA2026","KIAA2026",TRUE
+"235021_at",0.98539961718117,0.928646171081048,0.0905724150269777,-5.93568871511022,0.0441328454778223,"KIAA2026","KIAA2026",TRUE
+"212162_at",0.656107731346623,0.124441466375208,-1.59695231284103,-4.76847129131653,-0.496091801767735,"KIDINS220","kinase D-interacting substrate 220kDa",TRUE
+"212163_at",0.843461221384182,0.438210478157691,-0.789459860912956,-5.64059828246167,-0.206189506862096,"KIDINS220","kinase D-interacting substrate 220kDa",TRUE
+"214932_at",0.896139457361073,0.578653475850003,0.563649416564948,-5.78611670801812,0.446965338542486,"KIDINS220","kinase D-interacting substrate 220kDa",TRUE
+"242032_at",0.951926058281945,0.779754087342048,0.28306596449992,-5.90073207337189,0.101846425615334,"KIDINS220","kinase D-interacting substrate 220kDa",TRUE
+"1557246_at",0.988737747949649,0.945738743074305,-0.0688345789196709,-5.93737594207341,-0.0310832021369398,"KIDINS220","kinase D-interacting substrate 220kDa",TRUE
+"204444_at",0.94895689004559,0.767957654608259,0.298693088020671,-5.89632207702829,0.100596790361164,"KIF11","kinesin family member 11",TRUE
+"229258_at",0.318933071531282,0.00697073654284192,-2.97389357006394,-2.36065654340289,-1.79096948449281,"KIF12","kinesin family member 12",TRUE
+"223520_s_at",0.407748633394319,0.0156853925508479,2.61704537099272,-3.06169579388486,1.24823575377602,"KIF13A","kinesin family member 13A",TRUE
+"232837_at",0.410469318323697,0.0159229791603497,2.61028277514573,-3.07458610918444,1.39613120714992,"KIF13A","kinesin family member 13A",TRUE
+"220777_at",0.614788745141381,0.0855554911835791,1.79961533918493,-4.47452358011034,0.926122418714962,"KIF13A","kinesin family member 13A",TRUE
+"235072_s_at",0.638101654979046,0.109286422475393,1.66850922572753,-4.6677120539603,0.866564131583623,"KIF13A","kinesin family member 13A",TRUE
+"237444_at",0.658906344891819,0.127057148499213,1.58534867747667,-4.7844879853969,0.733433451156817,"KIF13A","kinesin family member 13A",TRUE
+"230990_at",0.973071267819624,0.87028955334695,0.165193582402896,-5.92640078802564,0.105443214077557,"KIF13A","kinesin family member 13A",TRUE
+"202962_at",0.648323565874229,0.119490746654131,1.61948309569234,-4.73711277315232,0.720809472934761,"KIF13B","kinesin family member 13B",TRUE
+"206364_at",0.835952408568777,0.415783808911138,0.829293245812258,-5.61015583305955,0.331395705268053,"KIF14","kinesin family member 14",TRUE
+"236641_at",0.860714927752408,0.480573647685797,0.717481526769697,-5.69201624031387,0.285230131475975,"KIF14","kinesin family member 14",TRUE
+"219306_at",0.99783553534859,0.989978152709441,0.0127033568812532,-5.93960488110763,0.00560926873214918,"KIF15","kinesin family member 15",TRUE
+"219570_at",0.594149510544898,0.0711023364882537,-1.89581700920993,-4.32605402627221,-1.32567542967925,"KIF16B","kinesin family member 16B",TRUE
+"232083_at",0.774230543658252,0.290123832146088,-1.08376068736363,-5.38324992102751,-0.912692854412289,"KIF16B","kinesin family member 16B",TRUE
+"222144_at",0.646561172018775,0.117501545492352,1.62875637434753,-4.72410753474652,0.91742164564978,"KIF17","kinesin family member 17",TRUE
+"221258_s_at",0.906970705662734,0.615330941428724,0.509656881436889,-5.81395456887082,0.237889896194408,"KIF18A","kinesin family member 18A",TRUE
+"222039_at",0.828426831961877,0.398282155141901,0.861329923997646,-5.58465588698164,0.258967450449155,"KIF18B","kinesin family member 18B",TRUE
+"236426_at",0.821177545343491,0.382239936515626,0.891501051808308,-5.55981939287388,0.563728710240008,"KIF19","kinesin family member 19",TRUE
+"1553314_a_at",0.856857560656867,0.471227546148414,-0.733025743274109,-5.68130638915635,-0.388497218487621,"KIF19","kinesin family member 19",TRUE
+"203850_s_at",0.657015752622694,0.125477331359355,1.59233296445881,-4.77485836227472,1.05427685960103,"KIF1A","kinesin family member 1A",TRUE
+"225482_at",0.93919895813272,0.72796672342436,-0.352266893618745,-5.87942293660863,-0.501856911567339,"KIF1A","kinesin family member 1A",TRUE
+"203849_s_at",0.988065316951061,0.942925783588769,-0.0724093973995937,-5.93713007253319,-0.0792030836610929,"KIF1A","kinesin family member 1A",TRUE
+"225878_at",0.382348164866486,0.0120876003592309,2.73331328059841,-2.83761463354948,1.27285172402166,"KIF1B","kinesin family member 1B",TRUE
+"226968_at",0.481363249480408,0.0273095245752455,2.36309216352955,-3.53381817062211,1.09250473884092,"KIF1B","kinesin family member 1B",TRUE
+"228657_at",0.528176582660474,0.0407408301399913,2.17305747496352,-3.86918614218204,0.738987333476953,"KIF1B","kinesin family member 1B",TRUE
+"209234_at",0.833430578034454,0.410959052599419,-0.838037832150738,-5.60328501992005,-0.302250887317641,"KIF1B","kinesin family member 1B",TRUE
+"212453_at",0.998435565,0.993559802844445,-0.00816324280817076,-5.93965102362866,-0.00295016040217355,"KIF1BP","KIF1 binding protein",TRUE
+"209244_s_at",0.446963972064621,0.0211513456516742,2.48133326938177,-3.31715333701473,0.818479678197264,"KIF1C","kinesin family member 1C",TRUE
+"238477_at",0.730819267705703,0.213413853344615,1.28107566748186,-5.17046685161482,0.673727119814881,"KIF1C","kinesin family member 1C",TRUE
+"209245_s_at",0.84772210282622,0.446853180572135,0.774445860505988,-5.65170677270159,0.644086841239714,"KIF1C","kinesin family member 1C",TRUE
+"218755_at",0.89980840440915,0.591753465005185,0.5441784008856,-5.79646963374918,0.179850325915869,"KIF20A","kinesin family member 20A",TRUE
+"234744_x_at",0.723655063748891,0.200465061343139,1.31953056844421,-5.1254451559764,0.793962973588964,"KIF20B","kinesin family member 20B",TRUE
+"205235_s_at",0.826140850652187,0.394114434487754,0.869091341640909,-5.57834265870457,0.259629385265361,"KIF20B","kinesin family member 20B",TRUE
+"234748_x_at",0.90344422113846,0.604484397852068,0.525457717890961,-5.80608996233668,0.365032494824897,"KIF20B","kinesin family member 20B",TRUE
+"226003_at",0.697172073261335,0.167551494617223,-1.42689401962285,-4.99386733268624,-0.595189995293563,"KIF21A","kinesin family member 21A",TRUE
+"231875_at",0.962555471240652,0.829249873849575,-0.21822673059281,-5.91651470195922,-0.0985392850218121,"KIF21A","kinesin family member 21A",TRUE
+"204411_at",0.961475152596758,0.82536508984232,-0.223277682211887,-5.91543108858785,-0.16275835269114,"KIF21B","kinesin family member 21B",TRUE
+"202183_s_at",0.562870988664324,0.0554068890899203,-2.02206752852625,-4.12311678331221,-0.727205627907436,"KIF22","kinesin family member 22",TRUE
+"216969_s_at",0.694089266511339,0.16343310867978,-1.44148472233001,-4.97533148499142,-0.498243017678222,"KIF22","kinesin family member 22",TRUE
+"204709_s_at",0.850206060456713,0.452849953618113,0.764131951140036,-5.65922113961472,0.287452978713585,"KIF23","kinesin family member 23",TRUE
+"244427_at",0.87222573050591,0.515087780275717,0.661539516305177,-5.72874664930346,0.324887895898147,"KIF23","kinesin family member 23",TRUE
+"220652_at",0.93089781226267,0.693946648965742,0.398677947843548,-5.86256279020148,0.261361353277495,"KIF24","kinesin family member 24",TRUE
+"208128_x_at",0.530381742213219,0.041528381132415,2.1637899901655,-3.88510542777094,1.48992800496029,"KIF25","kinesin family member 25",TRUE
+"207682_s_at",0.972819824894874,0.868368114524914,0.167664551983737,-5.92600072139055,0.113332537643368,"KIF25","kinesin family member 25",TRUE
+"211351_at",0.838294736493351,0.42303654891739,-0.816267657457973,-5.62026521579448,-0.73559768218128,"KIF25-AS1","KIF25 antisense RNA 1",TRUE
+"211350_s_at",0.92147071434021,0.665279103390314,0.438486856971181,-5.84646692634635,0.253610223203144,"KIF25-AS1","KIF25 antisense RNA 1",TRUE
+"207963_at",0.924895797380467,0.675110496161995,-0.424756578640271,-5.85218846136224,-0.20947971868111,"KIF25-AS1","KIF25 antisense RNA 1",TRUE
+"232069_at",0.55092132555352,0.0491961003989523,-2.08101521202154,-4.02538175037214,-2.28718282797081,"KIF26A","kinesin family member 26A",TRUE
+"234307_s_at",0.592488489935347,0.0694285439855273,-1.9080374759045,-4.30680410692263,-2.47472424456559,"KIF26A","kinesin family member 26A",TRUE
+"238617_at",0.792384092929646,0.323576765301147,-1.00961980558298,-5.45503743936685,-1.18856160470768,"KIF26B","kinesin family member 26B",TRUE
+"220002_at",0.912252515563073,0.632404983412803,-0.485045872885708,-5.82573751868178,-0.333430398427564,"KIF26B","kinesin family member 26B",TRUE
+"1555164_at",0.961876388239691,0.826870637835459,0.221319488313611,-5.91585412162645,0.181246309182282,"KIF26B","kinesin family member 26B",TRUE
+"232514_at",0.910539438829498,0.627660190398627,0.491854082575366,-5.82253494616442,0.417895356012845,"KIF27","kinesin family member 27",TRUE
+"203086_at",0.657015752622694,0.12600834496673,-1.58997725778644,-4.77810999531823,-0.537673390912023,"KIF2A","kinesin family member 2A",TRUE
+"203087_s_at",0.954614142466984,0.79301167525604,-0.265588501086683,-5.90538566433546,-0.0855315957804859,"KIF2A","kinesin family member 2A",TRUE
+"223926_at",0.798428326317339,0.332830542451624,0.990068104032549,-5.47320243774097,0.631962222803711,"KIF2B","kinesin family member 2B",TRUE
+"211519_s_at",0.78885145722244,0.315140772954276,1.0277858818858,-5.43787165757675,0.349190156634531,"KIF2C","kinesin family member 2C",TRUE
+"209408_at",0.813442508625161,0.363528752565235,0.927760703068705,-5.52892537504783,0.276451871421317,"KIF2C","kinesin family member 2C",TRUE
+"228680_at",0.44839970337033,0.0213230768863806,-2.47762498815484,-3.32403490580627,-1.12034884479895,"KIF3A","kinesin family member 3A",TRUE
+"213623_at",0.823074246722209,0.389449766563024,-0.877841449249365,-5.57116212105475,-0.390121709707408,"KIF3A","kinesin family member 3A",TRUE
+"225205_at",0.788144775381206,0.314349759794018,1.02950664418677,-5.43623131189434,0.300963600695926,"KIF3B","kinesin family member 3B",TRUE
+"203943_at",0.8920930097751,0.563519038529036,0.586422423262664,-5.77356061931265,0.197630421026302,"KIF3B","kinesin family member 3B",TRUE
+"203390_s_at",0.147189326785666,0.00102158293838414,3.77934432488217,-0.675406403768796,1.45056365574693,"KIF3C","kinesin family member 3C",TRUE
+"203389_at",0.177038278441109,0.00158338762062556,3.59860286007486,-1.06160955043465,1.47647386778516,"KIF3C","kinesin family member 3C",TRUE
+"218355_at",0.9802233499944,0.907198665167348,0.117913440881022,-5.93291382788795,0.0368695572048718,"KIF4A","kinesin family member 4A",TRUE
+"223933_at",0.619281048427601,0.0894913500434655,1.77587218171736,-4.51030867313201,1.61896312202051,"KIF5A","kinesin family member 5A",TRUE
+"229921_at",0.774230543658252,0.290017655748513,1.08400546808284,-5.38300536648548,0.560721100324251,"KIF5A","kinesin family member 5A",TRUE
+"205318_at",0.81035488031479,0.354198252675701,0.946308160178159,-5.51268456014365,0.344098711987585,"KIF5A","kinesin family member 5A",TRUE
+"201992_s_at",0.308861881799719,0.00639592226245507,3.01097727603675,-2.2857288121591,0.720437274953685,"KIF5B","kinesin family member 5B",TRUE
+"201991_s_at",0.713633547141264,0.188688226003829,1.35622579532386,-5.08143838605525,0.330963197687215,"KIF5B","kinesin family member 5B",TRUE
+"224662_at",0.75067385436597,0.243654406514686,1.19779338995445,-5.26405189407184,0.292698879139998,"KIF5B","kinesin family member 5B",TRUE
+"203129_s_at",0.424529255176517,0.017951744635905,2.55611016797739,-3.17724926399905,1.4288808512678,"KIF5C","kinesin family member 5C",TRUE
+"1557089_at",0.636860247875294,0.107892539223877,1.67550266581204,-4.65768365875036,0.739283550094075,"KIF5C","kinesin family member 5C",TRUE
+"203130_s_at",0.778686132916778,0.299350942494863,-1.06272944622452,-5.40407734893356,-1.00712229238056,"KIF5C","kinesin family member 5C",TRUE
+"1556232_at",0.522873598058175,0.0386548712089829,-2.19841170720299,-3.8254190606003,-1.18111568674541,"KIF6","kinesin family member 6",TRUE
+"1552538_a_at",0.615637099066718,0.086109566920853,1.79621660726811,-4.47966726521911,1.01216899810278,"KIF6","kinesin family member 6",TRUE
+"232695_at",0.693742297578797,0.162907445328161,1.4433682816768,-4.97292741282953,0.504530526818071,"KIF6","kinesin family member 6",TRUE
+"1562639_at",0.8376750578867,0.422302316761637,-0.817579895426969,-5.61925355776361,-0.599229182027885,"KIF6","kinesin family member 6",TRUE
+"1556233_s_at",0.904832003218088,0.610082925628432,0.517285335850207,-5.81018684357244,0.244897731001684,"KIF6","kinesin family member 6",TRUE
+"229405_at",0.637485146909712,0.108308316064232,1.67340865997593,-4.66068974196287,1.15386227761728,"KIF7","kinesin family member 7",TRUE
+"230701_x_at",0.843816788557882,0.439679260831174,0.786895605861451,-5.64250974202951,0.276510851906542,"KIF9","kinesin family member 9",TRUE
+"231319_x_at",0.899808883319249,0.592014311173344,0.543792872018745,-5.79667105429486,0.281979197432095,"KIF9","kinesin family member 9",TRUE
+"223778_at",0.975196332002567,0.879513519268509,-0.153345926505874,-5.92823669026895,-0.085823660696132,"KIF9","kinesin family member 9",TRUE
+"228429_x_at",0.990810941805126,0.956402430002924,-0.0552906887057264,-5.93819460909846,-0.0194506016876286,"KIF9","kinesin family member 9",TRUE
+"1557613_at",0.951810226174863,0.779276593737769,-0.283697093569997,-5.90055852248546,-0.0696057958808032,"KIF9-AS1","KIF9 antisense RNA 1",TRUE
+"203333_at",0.892000472179706,0.562179601795011,-0.588452876294604,-5.77241774402729,-0.284941707849462,"KIFAP3","kinesin associated protein 3",TRUE
+"209680_s_at",0.65284137151906,0.121858826736251,1.60861056180491,-4.75228776694752,0.476937321416292,"KIFC1","kinesin family member C1",TRUE
+"226791_at",0.96523532155309,0.837984910986018,-0.206890494331009,-5.9188568660757,-0.146012286402582,"KIFC2","kinesin family member C2",TRUE
+"226792_s_at",0.976335130930535,0.885743419647975,0.145356777935781,-5.92939775885929,0.107677775018647,"KIFC2","kinesin family member C2",TRUE
+"209661_at",0.669423128374382,0.135531362465221,1.54906980454853,-4.83397321306199,1.41004661891314,"KIFC3","kinesin family member C3",TRUE
+"1559759_at",0.726535590042475,0.205557404858837,1.30418379773075,-5.14354793864279,0.859534868586265,"KIFC3","kinesin family member C3",TRUE
+"205664_at",0.821187434813103,0.382581722021705,0.890849727254132,-5.56036392702205,0.277110199017633,"KIN","Kin17 DNA and RNA binding protein",TRUE
+"236887_at",0.878647293269438,0.531682557934844,0.635389299723525,-5.74493671322451,0.321621425573562,"KIN","Kin17 DNA and RNA binding protein",TRUE
+"242603_x_at",0.951866720679735,0.779372976399994,-0.283569689931764,-5.90059358744352,-0.416117458056161,"KIN","Kin17 DNA and RNA binding protein",TRUE
+"210890_x_at",0.913123070637484,0.635227504211679,0.48100691586626,-5.82761681559799,0.159180341032496,"KIR2DL1","killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1",TRUE
+"211397_x_at",0.824671318715422,0.39211669451568,0.872830487949594,-5.57528240503085,0.425640363550198,"KIR2DL2","killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2",TRUE
+"208179_x_at",0.728523962638265,0.209969466909077,1.29112417337083,-5.15881148290529,0.977450958032665,"KIR2DL3","killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3",TRUE
+"211245_x_at",0.588653540532996,0.0674731512792197,1.9226457066659,-4.28368018759336,1.43334346588309,"KIR2DL4","killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4",TRUE
+"211242_x_at",0.848339436378604,0.448191172915921,0.772137395284796,-5.65339690495528,0.323252611559749,"KIR2DL4","killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4",TRUE
+"208426_x_at",0.853297110808539,0.459887971898639,0.752131763182746,-5.66784417841203,0.535865171425524,"KIR2DL4","killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4",TRUE
+"211410_x_at",0.978255630670068,0.894928565396332,0.133595348015029,-5.93099425284979,0.0772005378227032,"KIR2DL5A","killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A",TRUE
+"217296_at",0.832698390803128,0.409457635788607,-0.840772329083554,-5.60112264413278,-0.544039126409865,"KIR2DS1","killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1",TRUE
+"208198_x_at",0.997171203405,0.985808831942334,0.0179887560713527,-5.93952587061645,0.00757433978303634,"KIR2DS1","killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1",TRUE
+"211532_x_at",0.988065316951061,0.943018968217041,-0.0722909595219867,-5.93713841771713,-0.025078134295144,"KIR2DS2","killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2",TRUE
+"217318_x_at",0.755680395607226,0.249834089272908,-1.18174859213399,-5.28145532244091,-0.866402801486009,"KIR2DS2///KIR2DS4///KIR2DS1///KIR2DL3///KIR2DL2///KIR2DL1","killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2///killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4///killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1///killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3///killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2///killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1",TRUE
+"208122_x_at",0.454734118585032,0.0220734220525775,2.46174140671974,-3.35344871039686,0.957827871331439,"KIR2DS3","killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3",TRUE
+"216552_x_at",0.956110893827712,0.801506844219467,0.254433944082127,-5.90820175015259,0.188173753151666,"KIR2DS4","killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4",TRUE
+"208203_x_at",0.985031563903634,0.926052854129683,0.0938741648558055,-5.93539221697455,0.0306267085612646,"KIR2DS5","killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5",TRUE
+"211687_x_at",0.638134354959023,0.109409491324342,1.66789538865627,-4.66859075825406,1.21313415562972,"KIR3DL1","killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1",TRUE
+"207313_x_at",0.712877745962237,0.186867194423974,1.36205953437123,-5.07434920081767,1.0150169285358,"KIR3DL2///KIR3DL1","killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2///killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1",TRUE
+"207314_x_at",0.723649742218726,0.200278280144405,-1.32009921721039,-5.12477095175959,-0.930741870178589,"KIR3DL2///KIR3DL1","killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2///killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1",TRUE
+"211688_x_at",0.839425347843955,0.425286550365685,-0.812255248244149,-5.62334909269572,-0.42375622082158,"KIR3DL2///KIR3DL1","killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2///killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1",TRUE
+"216907_x_at",0.878787795787718,0.531965974891378,0.63494658888528,-5.74520540255446,0.409269326851624,"KIR3DL2///KIR3DL1","killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2///killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1",TRUE
+"216676_x_at",0.677013732819214,0.143957410547649,1.51480860020677,-4.87987366939091,0.543559887286862,"KIR3DL3","killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3",TRUE
+"211389_x_at",0.615821255316333,0.0863366053103758,1.79482939131567,-4.48176466689059,0.978425691158369,"KIR3DS1","killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1",TRUE
+"216492_at",0.97217147728768,0.866392819429712,-0.170205895257489,-5.92558308173985,-0.0633823010290904,"KIR3DX1","killer cell immunoglobulin like receptor, three Ig domains X1",TRUE
+"216428_x_at",0.997910625329654,0.990372681328536,0.0122032391831026,-5.9396109480324,0.00562681997552072,"KIR3DX1","killer cell immunoglobulin like receptor, three Ig domains X1",TRUE
+"220825_s_at",0.467361806748287,0.0245071111101479,2.41346602979198,-3.44222075732981,2.32888798509423,"KIRREL","kin of IRRE like (Drosophila)",TRUE
+"225303_at",0.647518308302168,0.118717916525694,1.62307040796316,-4.73208856728172,2.38915030234932,"KIRREL","kin of IRRE like (Drosophila)",TRUE
+"232467_at",0.808605089946517,0.351647863190476,0.951435080739963,-5.50814322945935,0.878832146228035,"KIRREL","kin of IRRE like (Drosophila)",TRUE
+"223755_at",0.983783029912313,0.920783603976245,-0.100586184352932,-5.93475678152444,-0.0607674640571565,"KIRREL2","kin of IRRE like 2 (Drosophila)",TRUE
+"240402_at",0.979976490833035,0.904553192253954,0.121291812603254,-5.93252049161598,0.0482681352788505,"KIRREL3","kin of IRRE like 3 (Drosophila)",TRUE
+"1569646_a_at",0.784918343662568,0.30963429920157,1.03982834560935,-5.42634006117767,0.714425317888094,"KIRREL3-AS2","KIRREL3 antisense RNA 2",TRUE
+"1553478_at",0.919485127002411,0.658108807788943,-0.448554854387698,-5.84215797791272,-0.211009126549697,"KIRREL3-AS3","KIRREL3 antisense RNA 3",TRUE
+"205563_at",0.576685359869221,0.0613805088377018,1.97068286278477,-4.20678670252345,1.80798420128078,"KISS1","KiSS-1 metastasis-suppressor",TRUE
+"242517_at",0.845449102453949,0.442478757507448,-0.782022648920197,-5.64612602022142,-0.922188026502367,"KISS1R","KISS1 receptor",TRUE
+"205051_s_at",0.662855903464759,0.130824949447052,1.56897826423306,-4.80692898318007,1.69249097002398,"KIT","KIT proto-oncogene receptor tyrosine kinase",TRUE
+"216974_at",0.975265330414469,0.880208987242545,0.152453569735986,-5.9283694515435,0.174589638462142,"KITLG","KIT ligand",TRUE
+"226534_at",0.977143718344719,0.890943813520468,-0.138695288603717,-5.93031848877609,-0.126845101205493,"KITLG","KIT ligand",TRUE
+"207029_at",0.998038817582822,0.990858425405718,-0.0115874980813268,-5.93961808293973,-0.0106754184929905,"KITLG","KIT ligand",TRUE
+"211124_s_at",0.999273244594744,0.997623826167755,-0.00301187820396343,-5.93967906240057,-0.00334271503026251,"KITLG","KIT ligand",TRUE
+"228290_at",0.778481681746654,0.298481756002295,-1.06469062145824,-5.40215062101014,-0.825391191029469,"KIZ","kizuna centrosomal protein",TRUE
+"228291_s_at",0.896345073598643,0.580506825968316,0.560881475578707,-5.78760998283743,0.223560375528674,"KIZ","kizuna centrosomal protein",TRUE
+"233241_at",0.95388518141013,0.786986923645283,0.273520117063577,-5.90331025259428,0.229520014657648,"KIZ","kizuna centrosomal protein",TRUE
+"240521_at",0.969450447163359,0.854543251768714,-0.185475855412237,-5.92294175622462,-0.0925239653714796,"KIZ","kizuna centrosomal protein",TRUE
+"219961_s_at",0.971216837324271,0.862898445367256,-0.17470445352861,-5.92482843697062,-0.204835093710512,"KIZ","kizuna centrosomal protein",TRUE
+"1569698_s_at",0.767011398042819,0.268394053512187,1.13527069890241,-5.33070762353981,0.828479040580698,"KIZ-AS1","KIZ antisense RNA 1",TRUE
+"1560673_at",0.999500506744552,0.99850013079556,0.00190113156295138,-5.93968172035639,0.00123562168792812,"KIZ-AS1","KIZ antisense RNA 1",TRUE
+"205978_at",0.581336273502073,0.0637413700972389,1.95158986790657,-4.2375045006271,2.51416011567478,"KL","klotho",TRUE
+"235708_at",0.60855164428531,0.0812292620026373,-1.82682761344148,-4.43308701664869,-1.18380231132791,"KLB","klotho beta",TRUE
+"244276_at",0.85334340854827,0.460952282761237,0.750326668472446,-5.66913009751853,0.536974644584117,"KLB","klotho beta",TRUE
+"213656_s_at",0.823718501969623,0.390789834889622,0.875320784166855,-5.573237485866,0.330291147507117,"KLC1","kinesin light chain 1",TRUE
+"212877_at",0.844169896707408,0.440558898509438,-0.785362417855858,-5.64364982059062,-0.401938309425038,"KLC1","kinesin light chain 1",TRUE
+"232036_at",0.940031619815611,0.730568332678645,0.348751242360309,-5.8806162519,0.200288785827205,"KLC1","kinesin light chain 1",TRUE
+"212878_s_at",0.975398143273847,0.881577022026082,0.150698609827512,-5.92862829216588,0.0657806228608351,"KLC1","kinesin light chain 1",TRUE
+"218906_x_at",0.929105090967597,0.688022074496499,0.406849371246938,-5.85938167880217,0.113719812932947,"KLC2","kinesin light chain 2",TRUE
+"1570402_at",0.402463840838386,0.0146457839595389,2.64781666886886,-3.00283857240742,1.02753768765336,"KLC3","kinesin light chain 3",TRUE
+"239853_at",0.565956563686213,0.0568492628763545,2.00922543149319,-4.14416273359094,1.49023579708085,"KLC3","kinesin light chain 3",TRUE
+"1552749_a_at",0.741260241503758,0.231713428902592,1.22968480959768,-5.22885563380429,0.620117881594565,"KLC3","kinesin light chain 3",TRUE
+"225596_at",0.95743098854986,0.807924557659639,-0.246029082952668,-5.91024432723706,-0.0827487508105111,"KLC4","kinesin light chain 4",TRUE
+"1553675_at",0.981916239902567,0.913237033330253,0.110207407635014,-5.93376950230689,0.0827723497024593,"KLC4","kinesin light chain 4",TRUE
+"210504_at",0.839519981963042,0.426401080585823,0.810272623998197,-5.62486764515308,0.572055463295182,"KLF1","Kruppel like factor 1",TRUE
+"202393_s_at",0.846560766727904,0.44493293095389,0.777766264871523,-5.6492674062088,0.327768392929732,"KLF10","Kruppel like factor 10",TRUE
+"218486_at",0.898647305933017,0.588345418379336,-0.54922317190556,-5.79382119919473,-0.24627994092091,"KLF11","Kruppel like factor 11",TRUE
+"1553137_s_at",0.921980251030053,0.667085531708961,-0.435957691000883,-5.84753428266346,-0.161048853272809,"KLF11","Kruppel like factor 11",TRUE
+"206965_at",0.291178024882244,0.00510462890812938,3.10757090267782,-2.08900827774463,3.0649360691001,"KLF12","Kruppel like factor 12",TRUE
+"227261_at",0.54295328972902,0.0459471769120749,2.11456075359732,-3.96895223670162,1.30712631415093,"KLF12","Kruppel like factor 12",TRUE
+"229881_at",0.560295667354693,0.0542637588222833,2.03245847960166,-4.10602273812026,2.34364106373337,"KLF12","Kruppel like factor 12",TRUE
+"239019_at",0.563430805981458,0.0556874162068829,2.01954675583664,-4.12725492205631,1.42506858060017,"KLF12","Kruppel like factor 12",TRUE
+"208467_at",0.62110896023334,0.0913913700185707,1.76473054814031,-4.52698123820427,1.31420340257356,"KLF12","Kruppel like factor 12",TRUE
+"214276_at",0.736020435324742,0.221180063657152,1.25886913203325,-5.19594866387509,0.65255190568091,"KLF12","Kruppel like factor 12",TRUE
+"206966_s_at",0.8017109011727,0.339118557812023,0.976995887507709,-5.48516729295421,0.377550313292554,"KLF12","Kruppel like factor 12",TRUE
+"238940_at",0.93474377881867,0.710130100427956,0.376495210930683,-5.8708777851574,0.222950925892519,"KLF12","Kruppel like factor 12",TRUE
+"225390_s_at",0.668518995965071,0.134745938161698,1.55235205693011,-4.82953324758737,0.923372200316914,"KLF13","Kruppel like factor 13",TRUE
+"219878_s_at",0.680972290639028,0.148859955776381,1.49562467759066,-4.90521683001368,1.5748195723767,"KLF13","Kruppel like factor 13",TRUE
+"230094_at",0.883515015273005,0.541669620269484,-0.619865011810972,-5.7542510066195,-0.33517168139506,"KLF13","Kruppel like factor 13",TRUE
+"1564463_at",0.921388946695144,0.665102104420983,-0.438734827961339,-5.84636195159938,-0.313975831330716,"KLF13","Kruppel like factor 13",TRUE
+"1552813_at",0.358427723880268,0.0101530194326885,2.81022629056623,-2.68696777124822,1.92706877971907,"KLF14","Kruppel like factor 14",TRUE
+"1552814_a_at",0.784918343662568,0.309608546912152,1.0398850182299,-5.42628550664093,0.778601120200298,"KLF14","Kruppel like factor 14",TRUE
+"221302_at",0.693738850178592,0.162741554501886,-1.44396371914286,-4.97216689645427,-0.74833739031634,"KLF15","Kruppel like factor 15",TRUE
+"231015_at",0.985425981490741,0.929052783919352,0.0900548196699857,-5.93573423363214,0.0791340710188804,"KLF15","Kruppel like factor 15",TRUE
+"224111_x_at",0.643541445483104,0.11419550258943,-1.64446403200008,-4.70194821585347,-0.919330782145762,"KLF16","Kruppel like factor 16",TRUE
+"226328_at",0.932269331146744,0.701286324673974,-0.388592856179154,-5.86640123998036,-0.235754823239427,"KLF16","Kruppel like factor 16",TRUE
+"1553891_at",0.780216511409289,0.30157795693092,1.0577230128013,-5.40898140532434,0.772730418113158,"KLF17","Kruppel like factor 17",TRUE
+"219371_s_at",0.812644903778517,0.36131202866759,-0.93213796382053,-5.52511911736974,-0.883737205633947,"KLF2","Kruppel like factor 2",TRUE
+"226646_at",0.912252515563073,0.632521523866273,-0.484878944797642,-5.82581549344106,-0.321077876778784,"KLF2","Kruppel like factor 2",TRUE
+"225140_at",0.612420348961838,0.0842031188180616,1.8079914002221,-4.46181706806019,0.779902026489845,"KLF3","Kruppel like factor 3",TRUE
+"222913_at",0.67818193964437,0.145564810480863,1.50846066912537,-4.88828829857557,0.604890692653436,"KLF3","Kruppel like factor 3",TRUE
+"225133_at",0.757125047459677,0.252998164007102,1.17364801711812,-5.2901640109632,0.491191050294823,"KLF3","Kruppel like factor 3",TRUE
+"219657_s_at",0.766550448794594,0.267398199971432,1.13770320896402,-5.32817301135289,0.418305854411445,"KLF3","Kruppel like factor 3",TRUE
+"1570414_x_at",0.94895689004559,0.76946566902241,0.29669121649486,-5.89690012946755,0.146754039912476,"KLF3-AS1","KLF3 antisense RNA 1",TRUE
+"219871_at",0.991689960875868,0.961338824303359,-0.0490247455634408,-5.9385129285136,-0.0433847451447704,"KLF3-AS1","KLF3 antisense RNA 1",TRUE
+"220266_s_at",0.831875452294783,0.407457197679382,0.844425607631439,-5.59822345440689,0.795247068974186,"KLF4","Kruppel like factor 4",TRUE
+"221841_s_at",0.937113154905832,0.720117216023642,0.362901914645591,-5.8757411192233,0.354690263449269,"KLF4","Kruppel like factor 4",TRUE
+"209212_s_at",0.079598562662188,0.000266420429212262,4.32900108945112,0.509950641963357,2.68548293528843,"KLF5","Kruppel like factor 5",TRUE
+"209211_at",0.306787493213918,0.0061608136021267,3.0270758689046,-2.25309563944698,2.34646812882377,"KLF5","Kruppel like factor 5",TRUE
+"208961_s_at",0.505411134618713,0.0329574711007997,2.2745972882528,-3.69205900529405,1.20880832811917,"KLF6","Kruppel like factor 6",TRUE
+"208960_s_at",0.521655713381635,0.0379351278720692,2.20744865449901,-3.80974397619881,1.29919625288367,"KLF6","Kruppel like factor 6",TRUE
+"1555832_s_at",0.606138724709726,0.0798429098373927,1.83581373459908,-4.41930553737196,0.8990657456741,"KLF6","Kruppel like factor 6",TRUE
+"224606_at",0.615637099066718,0.08614978408705,1.79597064848392,-4.48003922853412,0.886893930028883,"KLF6","Kruppel like factor 6",TRUE
+"211610_at",0.6708432030569,0.136743797429269,1.5440337811551,-4.84077109764052,0.488140682345876,"KLF6","Kruppel like factor 6",TRUE
+"204334_at",0.557622954313023,0.0525649511939519,2.04826685931141,-4.07990572563844,1.01309656198206,"KLF7","Kruppel like factor 7",TRUE
+"238482_at",0.579111490485788,0.0621516962279863,1.96437572573384,-4.2169564589601,0.71849575671091,"KLF7","Kruppel like factor 7",TRUE
+"1555420_a_at",0.585036027492332,0.0654354023270936,1.9382706933142,-4.25881198233942,1.17981486357889,"KLF7","Kruppel like factor 7",TRUE
+"240432_x_at",0.597654932724127,0.0749223488111431,1.86884343033993,-4.36823616021163,1.28558714237663,"KLF7","Kruppel like factor 7",TRUE
+"238517_at",0.775430121387967,0.292358784129704,1.07862307448355,-5.38837141095828,0.66538638192381,"KLF7","Kruppel like factor 7",TRUE
+"230986_at",0.921729477898827,0.666508451988571,0.436765340875411,-5.8471940977643,0.4906206110402,"KLF8","Kruppel like factor 8",TRUE
+"219930_at",0.98539961718117,0.928414659848855,-0.090867127168909,-5.93566268098565,-0.127124125671667,"KLF8","Kruppel like factor 8",TRUE
+"203543_s_at",0.508488499910913,0.0335351142032735,-2.26634750670672,-3.70663098646065,-1.54652670883068,"KLF9","Kruppel like factor 9",TRUE
+"203542_s_at",0.593339168375633,0.0703890629083521,-1.90099349908587,-4.3179104495641,-0.972372488813363,"KLF9","Kruppel like factor 9",TRUE
+"230636_s_at",0.839519981963042,0.426494729331595,-0.810106180632461,-5.62499497076282,-0.333390248145994,"KLF9","Kruppel like factor 9",TRUE
+"203541_s_at",0.899709895975363,0.591315508038019,0.544825886006646,-5.79613104135637,0.319836231413302,"KLF9","Kruppel like factor 9",TRUE
+"228474_s_at",0.912722788750542,0.634159058427509,0.482534877089604,-5.82690767331763,0.386744593800195,"KLF9","Kruppel like factor 9",TRUE
+"1564272_a_at",0.896115372949367,0.577557097907053,0.565288930615547,-5.78522884568341,0.679332822264413,"KLHDC1","kelch domain containing 1",TRUE
+"1552733_at",0.986421906591669,0.936589015121014,0.0804660267991013,-5.93653034541091,0.0534728333440002,"KLHDC1","kelch domain containing 1",TRUE
+"210111_s_at",0.870808709484996,0.510262547051642,-0.66923019777266,-5.72386607406123,-0.192357739368484,"KLHDC10","kelch domain containing 10",TRUE
+"209254_at",0.906661280810015,0.614705569608531,0.510564299558505,-5.81350925117223,0.179934955049731,"KLHDC10","kelch domain containing 10",TRUE
+"242746_at",0.962125056232529,0.828007830480245,-0.219840983404259,-5.91617106900812,-0.148821900509781,"KLHDC10","kelch domain containing 10",TRUE
+"209256_s_at",0.970353888480813,0.858969200581507,-0.179767268087296,-5.92395566331613,-0.0542478578553354,"KLHDC10","kelch domain containing 10",TRUE
+"209255_at",0.993083193605528,0.96718113748493,-0.0416114647885714,-5.93884015930906,-0.0125029655183244,"KLHDC10","kelch domain containing 10",TRUE
+"217906_at",0.741734366005262,0.23225408954751,-1.22821429558502,-5.23049612368316,-0.507501345470841,"KLHDC2","kelch domain containing 2",TRUE
+"208784_s_at",0.778686132916778,0.299333087931163,-1.06276969120065,-5.40403784283301,-0.354834215631806,"KLHDC3","kelch domain containing 3",TRUE
+"214383_x_at",0.816800680706682,0.368830462192443,-0.917363491445054,-5.53790017876561,-0.312542652855301,"KLHDC3","kelch domain containing 3",TRUE
+"237900_at",0.580630437263151,0.063310897510256,1.95502413785551,-4.23199430581461,0.647095222499579,"KLHDC4","kelch domain containing 4",TRUE
+"221219_s_at",0.641581234599539,0.112036652442695,-1.65492878903243,-4.68709483635421,-0.787042579928942,"KLHDC4","kelch domain containing 4",TRUE
+"1556616_a_at",0.828943982183432,0.399939886712698,0.858257333343004,-5.58714060660255,0.713206973084406,"KLHDC4","kelch domain containing 4",TRUE
+"232171_x_at",0.932918358096654,0.704018499406821,-0.384849217605993,-5.86780142763955,-0.124431985686607,"KLHDC4","kelch domain containing 4",TRUE
+"229035_s_at",0.942835367370539,0.743852700629091,0.330868159689486,-5.88650306919265,0.0937415483801924,"KLHDC4","kelch domain containing 4",TRUE
+"234738_s_at",0.96350209729653,0.833409429603529,0.21282494947133,-5.91764626834307,0.0747273305991509,"KLHDC4","kelch domain containing 4",TRUE
+"1556012_at",0.630603891142543,0.101705797557539,-1.70749840848657,-4.61139901413107,-2.01250588667303,"KLHDC7A","kelch domain containing 7A",TRUE
+"1553437_at",0.936992192746977,0.717900898384323,-0.365912408039455,-5.87467925767394,-0.190891929419246,"KLHDC7A","kelch domain containing 7A",TRUE
+"236285_at",0.0197959156020234,1.37584781504689e-05,5.54882943088764,3.10209720710863,3.3636583483409,"KLHDC7B","kelch domain containing 7B",TRUE
+"1552639_at",0.0897427148869195,0.000347215610070137,4.22095497649104,0.276473468844806,2.57483659180609,"KLHDC7B","kelch domain containing 7B",TRUE
+"219331_s_at",0.716472449896956,0.192496546728651,1.34416762682075,-5.09601085121386,0.800456978232359,"KLHDC8A","kelch domain containing 8A",TRUE
+"222871_at",0.83030603167465,0.402469247937203,0.853584911940634,-5.59090321501762,0.483728243854991,"KLHDC8A","kelch domain containing 8A",TRUE
+"225755_at",0.999369827418759,0.998144626708046,0.00235174500111032,-5.93968078694719,0.00153433182935636,"KLHDC8B","kelch domain containing 8B",TRUE
+"227582_at",0.7994347047598,0.334435618469915,-0.986715248766397,-5.4762850698852,-1.07145108716382,"KLHDC9","kelch domain containing 9",TRUE
+"216391_s_at",0.946119745055175,0.755961356789764,0.314663261731275,-5.89157264567105,0.227679396750426,"KLHL1","kelch like family member 1",TRUE
+"223810_at",0.978928101156583,0.897512432960994,-0.130290295811742,-5.93141869158028,-0.128320444885076,"KLHL1","kelch like family member 1",TRUE
+"1552424_at",0.637485146909712,0.108941848971098,1.67023098553332,-4.66524605385061,0.751743268408283,"KLHL10","kelch like family member 10",TRUE
+"1552425_a_at",0.812302873476553,0.359159228987863,0.936406257618121,-5.52139175620492,0.327647247519319,"KLHL10","kelch like family member 10",TRUE
+"220657_at",0.784925710185113,0.31026046553862,-1.0384513749872,-5.42766474609258,-0.688560621638224,"KLHL11","kelch like family member 11",TRUE
+"226883_at",0.957017346544368,0.805427933935231,-0.249296562075447,-5.9094583561633,-0.0776692989452368,"KLHL11","kelch like family member 11",TRUE
+"225068_at",0.594972224548427,0.071642627996484,-1.89192610361799,-4.33216492025411,-0.809062468970838,"KLHL12","kelch like family member 12",TRUE
+"219931_s_at",0.791211889207316,0.321544654961134,-1.01396520909722,-5.45095650696703,-0.384349022176107,"KLHL12","kelch like family member 12",TRUE
+"227875_at",0.892780783477555,0.565910382916802,0.582803552317984,-5.77558808695045,0.594284578167537,"KLHL13","kelch like family member 13",TRUE
+"1554942_a_at",0.756313947022433,0.251582594514597,-1.17726272642552,-5.28628441061464,-0.930967614865485,"KLHL14","kelch like family member 14",TRUE
+"228377_at",0.839984323996376,0.428833697955388,0.805956456805424,-5.62816148284748,1.0037672507122,"KLHL14","kelch like family member 14",TRUE
+"1554941_at",0.988098729256575,0.943214170664879,-0.0720428601927507,-5.93715585464393,-0.0639959620690793,"KLHL14","kelch like family member 14",TRUE
+"226370_at",0.98687728101116,0.938653535083186,0.0778406030535086,-5.93673271842572,0.0444682904039393,"KLHL15","kelch like family member 15",TRUE
+"1555650_at",0.85334340854827,0.461518279145242,-0.749367740454423,-5.66981203159729,-0.433148401642478,"KLHL17","kelch like family member 17",TRUE
+"229792_at",0.961690794738111,0.826381818209254,-0.221955175106439,-5.91571719933882,-0.068288033435242,"KLHL17","kelch like family member 17",TRUE
+"212882_at",0.753827379204375,0.24700093110898,-1.18906721912735,-5.27354233904084,-0.369528481082265,"KLHL18","kelch like family member 18",TRUE
+"207976_at",0.89257557173125,0.564865246593013,-0.584384209541278,-5.77470401945231,-0.178131461905221,"KLHL18","kelch like family member 18",TRUE
+"1557165_s_at",0.985498770484702,0.92984552916882,0.0890457717299534,-5.9358222221972,0.0346553027249534,"KLHL18","kelch like family member 18",TRUE
+"219157_at",0.606900628956089,0.0804260328515266,1.832017650254,-4.42513327793735,1.20838508413657,"KLHL2","kelch like family member 2",TRUE
+"210634_at",0.6708432030569,0.136765188123351,-1.54394526297514,-4.84089042748986,-1.22209795638168,"KLHL20","kelch like family member 20",TRUE
+"204176_at",0.754579670006269,0.248072951524566,-1.18629062579848,-5.27654943914198,-0.34731945240892,"KLHL20","kelch like family member 20",TRUE
+"210635_s_at",0.872668627020452,0.51649184066001,-0.659309190772821,-5.7301519201311,-0.200642574849049,"KLHL20","kelch like family member 20",TRUE
+"204177_s_at",0.952697366942815,0.783630955774064,-0.277946017610751,-5.9021258025861,-0.0807162467972482,"KLHL20","kelch like family member 20",TRUE
+"203068_at",0.870980161749509,0.51111929377469,0.667861723737238,-5.72473847226148,0.513234245974646,"KLHL21","kelch like family member 21",TRUE
+"221838_at",0.677013732819214,0.143951224135362,-1.51483314342569,-4.87984108085455,-0.785031584127506,"KLHL22","kelch like family member 22",TRUE
+"221837_at",0.703902004301726,0.175518959773333,-1.39946435350238,-5.02829429237084,-1.16391455395376,"KLHL22","kelch like family member 22",TRUE
+"49329_at",0.838350471423215,0.423361583896702,-0.815687202084444,-5.62071222662381,-0.339933096906268,"KLHL22","kelch like family member 22",TRUE
+"221948_s_at",0.8931256786818,0.566748887459809,-0.581536486573273,-5.77629508829128,-0.384064429823389,"KLHL22","kelch like family member 22",TRUE
+"222141_at",0.897560972979555,0.584475224513431,0.554969575860064,-5.79077550311772,0.233356908187467,"KLHL22","kelch like family member 22",TRUE
+"241682_at",0.734577729521114,0.21899413650451,1.26505814624211,-5.18888511278691,1.22905297559131,"KLHL23","kelch like family member 23",TRUE
+"242088_at",0.940044918888428,0.7316039658288,0.347353001109012,-5.88108756808318,0.190726215811103,"KLHL24","kelch like family member 24",TRUE
+"221985_at",0.94677940770163,0.758705894801356,0.311002350721614,-5.89268302746089,0.131850695279711,"KLHL24","kelch like family member 24",TRUE
+"226158_at",0.982844899319041,0.91649087517381,0.106057788920978,-5.93420635528074,0.0559632822282872,"KLHL24","kelch like family member 24",TRUE
+"206551_x_at",0.99186228645105,0.962439582084602,-0.0476277973593246,-5.93857868369042,-0.0175678047039236,"KLHL24","kelch like family member 24",TRUE
+"221986_s_at",0.992511588832933,0.965088230330761,0.0442668469190371,-5.93872909944135,0.0206520432327775,"KLHL24","kelch like family member 24",TRUE
+"210307_s_at",0.625586175410773,0.0968099612281765,-1.73401335639839,-4.5725461804299,-1.01826618604496,"KLHL25","kelch like family member 25",TRUE
+"219354_at",0.873301865850313,0.518380273500293,-0.656314737555543,-5.73203149122709,-0.246027843570609,"KLHL26","kelch like family member 26",TRUE
+"228328_at",0.493519901382617,0.0298066852120638,-2.32207126258686,-3.60760204305511,-0.967281859903796,"KLHL28","kelch like family member 28",TRUE
+"220374_at",0.958640117088134,0.812495960951124,0.240053277977621,-5.91165509791921,0.166837248825977,"KLHL28","kelch like family member 28",TRUE
+"235727_at",0.979976490833035,0.904572414589471,-0.121267259766971,-5.93252339027179,-0.0547945104574907,"KLHL28","kelch like family member 28",TRUE
+"229310_at",0.797963285726587,0.332075149270399,0.991649911596497,-5.47174481473028,1.02530991224785,"KLHL29","kelch like family member 29",TRUE
+"1554261_at",0.836802432816621,0.418868019777326,0.823736828001597,-5.61448659524719,0.609886923928509,"KLHL29","kelch like family member 29",TRUE
+"1554262_s_at",0.947778780715578,0.762065916010302,-0.306526345271235,-5.89402314012016,-0.231610084441053,"KLHL29","kelch like family member 29",TRUE
+"220348_at",0.966051687342135,0.841527080592012,0.202301482255637,-5.91976962482476,0.202752474497397,"KLHL29","kelch like family member 29",TRUE
+"221221_s_at",0.54295328972902,0.0460269916978367,2.11371146456623,-3.97038801439888,1.52492175994002,"KLHL3","kelch like family member 3",TRUE
+"1555110_a_at",0.83030603167465,0.402344473322501,0.853814962351823,-5.59071840787834,0.590170409817398,"KLHL3","kelch like family member 3",TRUE
+"1554782_at",0.960693014177181,0.8214606146465,0.228360228673996,-5.91431579146885,0.113984792817893,"KLHL30-AS1","KLHL30 antisense RNA 1",TRUE
+"234782_at",0.471777506776789,0.0257221048607809,2.39100517493093,-3.48319514930427,0.755010289687817,"KLHL31","kelch like family member 31",TRUE
+"239398_at",0.97928472590149,0.899535156271195,-0.127704047812741,-5.93174341781108,-0.049579283570325,"KLHL31","kelch like family member 31",TRUE
+"1553765_a_at",0.968066640321622,0.850234294800993,-0.191039611086922,-5.92192317738256,-0.142304155308407,"KLHL32","kelch like family member 32",TRUE
+"1553873_at",0.218511506433,0.00265371084172862,3.38378101464849,-1.51585352298156,2.59040847136714,"KLHL34","kelch like family member 34",TRUE
+"238832_at",0.983894202058883,0.921126520727719,-0.100149233196293,-5.93479948186419,-0.0654782728971055,"KLHL34","kelch like family member 34",TRUE
+"1553611_s_at",0.547195868806649,0.0476149516334558,-2.09708386234778,-3.9984237418926,-1.55306364308777,"KLHL35","kelch like family member 35",TRUE
+"215748_at",0.892746695408886,0.565653540507602,0.583191860027306,-5.77537111968433,0.417626498836465,"KLHL35","kelch like family member 35",TRUE
+"214208_at",0.904432955312383,0.608186736012622,0.520049254295927,-5.80880826984177,0.235502831120777,"KLHL35","kelch like family member 35",TRUE
+"227319_at",0.817915083386752,0.370927884085273,-0.913277691782358,-5.54140150176714,-0.398481328809206,"KLHL36","kelch like family member 36",TRUE
+"238523_at",0.929125618312698,0.688148627839425,0.406674530632836,-5.85945040884093,0.190427892375574,"KLHL36","kelch like family member 36",TRUE
+"219453_at",0.937224988740666,0.721365351442736,0.361208038009723,-5.87633477570515,0.159236512784588,"KLHL36","kelch like family member 36",TRUE
+"1553027_a_at",0.964270089028129,0.835771289418454,-0.209760626047946,-5.91827563079909,-0.217840070022215,"KLHL4","kelch like family member 4",TRUE
+"214591_at",0.977874971442423,0.893057380458683,-0.135989749977244,-5.93068013111397,-0.126902708439581,"KLHL4","kelch like family member 4",TRUE
+"1555044_a_at",0.962125056232529,0.827983647125578,-0.219872419823455,-5.91616435197873,-0.1177480022521,"KLHL40","kelch like family member 40",TRUE
+"222827_s_at",0.862388151566272,0.485366405121122,0.709578712998069,-5.69737747886529,0.238409124605017,"KLHL41","kelch like family member 41",TRUE
+"219106_s_at",0.9340157600858,0.707548082545042,0.38002123337682,-5.8695874495819,0.415393725781341,"KLHL41","kelch like family member 41",TRUE
+"225963_at",0.347515673982638,0.00902971816595502,2.86155826831858,-2.58543181522946,0.998537065491622,"KLHL42","kelch like family member 42",TRUE
+"225732_at",0.937623890519979,0.724011373683094,-0.357620604373484,-5.87758301479298,-0.157915552054675,"KLHL42","kelch like family member 42",TRUE
+"225961_at",0.949038895598021,0.770114540586111,-0.295830228274169,-5.89714755965532,-0.137571039623264,"KLHL42","kelch like family member 42",TRUE
+"227565_at",0.212782084934004,0.00253742879518921,3.40251760678121,-1.47648936269676,1.9699451451514,"KLHL5","kelch like family member 5",TRUE
+"233866_at",0.323645710780045,0.00737562973263716,2.94949353221625,-2.40976621879487,1.6383677906618,"KLHL5","kelch like family member 5",TRUE
+"232297_at",0.328663980090165,0.00780342051193739,2.92506967327253,-2.45876777966215,1.77484825890069,"KLHL5","kelch like family member 5",TRUE
+"220682_s_at",0.484495305292367,0.0278153539194237,2.35451167631039,-3.5493125339616,0.971051565627528,"KLHL5","kelch like family member 5",TRUE
+"226001_at",0.512962828679001,0.0344123324228071,2.25406421819869,-3.72826930752679,1.89747445878034,"KLHL5","kelch like family member 5",TRUE
+"1555275_a_at",0.597879550155311,0.0753013844049258,1.86623296319721,-4.37229587931563,1.44788294636351,"KLHL6","kelch like family member 6",TRUE
+"1560396_at",0.62986301194198,0.10094810345307,-1.71152979499407,-4.60552059383683,-1.81266969166428,"KLHL6","kelch like family member 6",TRUE
+"1560397_s_at",0.756952614607938,0.252521542431,1.17486340180982,-5.28886072501549,0.47288035438195,"KLHL6","kelch like family member 6",TRUE
+"228167_at",0.961212424803935,0.823226310046724,0.226061028082972,-5.91482341444642,0.138658006160998,"KLHL6","kelch like family member 6",TRUE
+"220239_at",0.482262518773694,0.0274806831230054,2.36017249524505,-3.53909398553647,1.09522298178727,"KLHL7","kelch like family member 7",TRUE
+"223250_at",0.594972224548427,0.0717666542459419,1.89103655612864,-4.33356077223344,0.813260565768301,"KLHL7","kelch like family member 7",TRUE
+"220238_s_at",0.6134063931611,0.0847125448927127,1.80482265973127,-4.46662908143995,0.717568168884192,"KLHL7","kelch like family member 7",TRUE
+"242648_at",0.358427723880268,0.00996266845272741,-2.81853184859612,-2.67059170333554,-0.873444445604386,"KLHL8","kelch like family member 8",TRUE
+"226874_at",0.560295667354693,0.0542670119243376,-2.03242863354547,-4.10607192055491,-0.635550158319916,"KLHL8","kelch like family member 8",TRUE
+"1561206_at",0.766390367856479,0.266804506880712,-1.13915655476355,-5.32665638023102,-0.424371754844238,"KLHL8","kelch like family member 8",TRUE
+"233197_at",0.778397054392363,0.298119591378559,1.06550898871669,-5.40134568713398,0.397125480401215,"KLHL9","kelch like family member 9",TRUE
+"237123_x_at",0.837277736441724,0.419830910979285,-0.822007390397266,-5.61582898401707,-0.638520038387506,"KLHL9","kelch like family member 9",TRUE
+"213233_s_at",0.922635094827638,0.669220197569341,0.432972681294936,-5.84878621379326,0.536367346505727,"KLHL9","kelch like family member 9",TRUE
+"213117_at",0.994057527155985,0.972345019304837,-0.0350610448653578,-5.93908476304677,-0.0318078165766771,"KLHL9","kelch like family member 9",TRUE
+"216699_s_at",0.94282868233554,0.743778449501537,0.330967804032406,-5.88647111695222,0.119238089313477,"KLK1","kallikrein 1",TRUE
+"209792_s_at",0.0122184790004403,6.92771557409512e-06,5.83785561740531,3.69403504066622,7.03122819906283,"KLK10","kallikrein related peptidase 10",TRUE
+"215808_at",0.609532363331105,0.081742431646865,1.823535039862,-4.43812449118395,1.08082480881366,"KLK10","kallikrein related peptidase 10",TRUE
+"205470_s_at",0.698964478395166,0.170333840148828,1.41719886239996,-5.00609848299785,2.07057702869406,"KLK11","kallikrein related peptidase 11",TRUE
+"234316_x_at",0.769847953580141,0.278287797049676,1.1114556101794,-5.35526891504485,0.779288424558226,"KLK12","kallikrein related peptidase 12",TRUE
+"220782_x_at",0.90269187900892,0.602058748238487,0.529009776895058,-5.80428979092944,0.383580591268227,"KLK12","kallikrein related peptidase 12",TRUE
+"233586_s_at",0.99709957716848,0.985297442918862,-0.0186370710113205,-5.93951430545489,-0.0219728861819286,"KLK12","kallikrein related peptidase 12",TRUE
+"217315_s_at",0.477266692481162,0.0264974422584997,-2.37717898455362,-3.50831189321149,-0.781541720503101,"KLK13","kallikrein related peptidase 13",TRUE
+"216670_at",0.55937703282623,0.0531674078923523,2.04260916404124,-4.08926810223345,1.32516224119893,"KLK13","kallikrein related peptidase 13",TRUE
+"205783_at",0.831971841409434,0.408265713275068,0.842947693035612,-5.5993977197045,0.261780288605854,"KLK13","kallikrein related peptidase 13",TRUE
+"220573_at",0.83479065017201,0.413356877404789,0.833683841297316,-5.60671446828758,0.325698146107387,"KLK14","kallikrein related peptidase 14",TRUE
+"234966_at",0.183440015750259,0.00174129617145651,3.5592242327517,-1.14531662543885,1.56646510258513,"KLK15","kallikrein related peptidase 15",TRUE
+"233477_at",0.498206796273596,0.0311249355158914,2.30167421798647,-3.64401325612931,1.24069196251733,"KLK15","kallikrein related peptidase 15",TRUE
+"221462_x_at",0.709914655587487,0.182907478309388,1.37490127891387,-5.05865453662952,0.968911998290992,"KLK15","kallikrein related peptidase 15",TRUE
+"234495_at",0.739189560382301,0.226097111841381,1.24511673138085,-5.21153795322099,0.795491375966113,"KLK15","kallikrein related peptidase 15",TRUE
+"209854_s_at",0.4180749314337,0.017105324583762,2.57797645110651,-3.13593917537699,1.12562149714276,"KLK2","kallikrein related peptidase 2",TRUE
+"210339_s_at",0.786851686785014,0.312566155883814,1.03339787960636,-5.43251279957135,0.545904940051416,"KLK2","kallikrein related peptidase 2",TRUE
+"209855_s_at",0.809707978333974,0.353057933603517,0.948597391331922,-5.51065958052584,0.272552918638267,"KLK2","kallikrein related peptidase 2",TRUE
+"1555545_at",0.828239270394399,0.398043503307916,0.861772940313581,-5.58429695014862,0.331618955874816,"KLK2","kallikrein related peptidase 2",TRUE
+"204583_x_at",0.406049718268978,0.015280304966705,2.62880076891437,-3.03925005343406,1.2227002366049,"KLK3","kallikrein related peptidase 3",TRUE
+"204582_s_at",0.683838837468118,0.152811744921876,1.48053292132458,-4.92497158616226,1.08672620060001,"KLK3","kallikrein related peptidase 3",TRUE
+"231629_x_at",0.788656989718963,0.314855207091107,1.02840674872455,-5.43728009133123,0.388869536831754,"KLK3","kallikrein related peptidase 3",TRUE
+"233854_x_at",0.537812056429653,0.0436840117531612,2.13921316425767,-3.92711641362327,0.955526774873278,"KLK4","kallikrein related peptidase 4",TRUE
+"231782_s_at",0.648954261038999,0.119756612639191,1.61825349311131,-4.73883291589515,0.881235988744037,"KLK4","kallikrein related peptidase 4",TRUE
+"224062_x_at",0.702809964629668,0.174665316460303,1.40235501706346,-5.0246921675633,0.924653544201957,"KLK4","kallikrein related peptidase 4",TRUE
+"1555697_at",0.794090864301234,0.325844203326811,1.00479356035499,-5.45955133574898,0.601564547687545,"KLK4","kallikrein related peptidase 4",TRUE
+"1555737_a_at",0.857110337466729,0.471744599874536,0.732161086613552,-5.68190785854788,0.241924002475538,"KLK4","kallikrein related peptidase 4",TRUE
+"222242_s_at",0.068995860470504,0.000190550981820688,4.46571518239433,0.805146779984643,5.3349476235573,"KLK5","kallikrein related peptidase 5",TRUE
+"204733_at",0.412728274083545,0.016548803010245,2.59291286237587,-3.10762027320094,3.37637448507271,"KLK6","kallikrein related peptidase 6",TRUE
+"239381_at",0.0561060899069991,0.000110826844260739,4.6870430536037,1.28171423586614,2.38985390512835,"KLK7","kallikrein related peptidase 7",TRUE
+"205778_at",0.269756594921198,0.00417894532964344,3.19263318350502,-1.91405689275452,3.06459507499014,"KLK7","kallikrein related peptidase 7",TRUE
+"206125_s_at",0.296090407530139,0.00529080353996392,3.09228056755694,-2.12029147057476,2.80680814143378,"KLK8","kallikrein related peptidase 8",TRUE
+"1552319_a_at",0.517859245504688,0.0369236362278785,2.22041567895844,-3.78718354739584,1.67369043061304,"KLK8","kallikrein related peptidase 8",TRUE
+"233687_s_at",0.990311291015875,0.951550135775382,0.0614520908292685,-5.9378443226601,0.0439616206598545,"KLK9///KLK8","kallikrein related peptidase 9///kallikrein related peptidase 8",TRUE
+"206541_at",0.980009054680439,0.905638341032981,-0.119905862819816,-5.93268319684367,-0.0908583494692374,"KLKB1","kallikrein B1",TRUE
+"244431_at",0.66909275739297,0.135164036489376,1.55060288270467,-4.83190031245169,0.532961231100865,"KLLN","killin, p53-regulated DNA replication inhibitor",TRUE
+"207229_at",0.688388924996666,0.157759729862062,-1.46207767750816,-4.94890910878429,-0.492336941447026,"KLRA1P","killer cell lectin like receptor A1, pseudogene",TRUE
+"214470_at",0.731548533938014,0.21521609584626,1.27586767047576,-5.17647713380657,0.82075774056063,"KLRB1","killer cell lectin like receptor B1",TRUE
+"206785_s_at",0.673366993714442,0.139500992956126,1.53271694609121,-4.85598316600682,1.49617615366606,"KLRC2///KLRC1","killer cell lectin like receptor C2///killer cell lectin like receptor C1",TRUE
+"207723_s_at",0.997321349050865,0.986390941308714,-0.0172507948091172,-5.93953853670979,-0.0196534323507969,"KLRC3","killer cell lectin like receptor C3",TRUE
+"210690_at",0.940227139261806,0.732310263302886,0.346399811316011,-5.88140779447429,0.239155290751301,"KLRC4","killer cell lectin like receptor C4",TRUE
+"205821_at",0.498206796273596,0.0310660557078822,2.30256819616879,-3.64242130235245,1.51642020928356,"KLRC4-KLRK1///KLRK1","KLRC4-KLRK1 readthrough///killer cell lectin like receptor K1",TRUE
+"1555691_a_at",0.771623843789204,0.281018509635434,1.10499146150473,-5.36185597717961,1.02315453941105,"KLRC4-KLRK1///KLRK1","KLRC4-KLRK1 readthrough///killer cell lectin like receptor K1",TRUE
+"207795_s_at",0.54295328972902,0.045878542174198,2.115292140751,-3.96771548522767,1.19174834252713,"KLRD1","killer cell lectin like receptor D1",TRUE
+"210606_x_at",0.894205199149904,0.570510225788484,0.575864488111013,-5.77944170736565,0.391822812563145,"KLRD1","killer cell lectin like receptor D1",TRUE
+"207796_x_at",0.923124080520773,0.670575566640028,0.431079475964321,-5.84957585773679,0.134417154089419,"KLRD1","killer cell lectin like receptor D1",TRUE
+"220646_s_at",0.968035667633768,0.849165471213234,-0.192420632329885,-5.92166570120318,-0.231768944388912,"KLRF1","killer cell lectin like receptor F1",TRUE
+"210288_at",0.734730148360473,0.219476526039718,1.2636882968103,-5.19045108367481,0.372555013230326,"KLRG1","killer cell lectin like receptor G1",TRUE
+"244264_at",0.765278605568716,0.265487741910193,-1.14238846899075,-5.32327761816351,-0.933683481536947,"KLRG2","killer cell lectin like receptor G2",TRUE
+"231195_at",0.767704684098492,0.269527034631413,-1.13251127917366,-5.33357707228994,-1.69347672628196,"KLRG2","killer cell lectin like receptor G2",TRUE
+"211138_s_at",0.875279162021058,0.522468504425849,0.649852665391502,-5.73605965728937,0.653647777769167,"KMO","kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)",TRUE
+"205306_x_at",0.947926063538122,0.763039304661661,0.30523085627438,-5.89440741629035,0.344797113289645,"KMO","kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)",TRUE
+"205307_s_at",0.995111934465262,0.977043228560098,0.0291027071252308,-5.93927096249693,0.0205642775661312,"KMO","kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)",TRUE
+"212079_s_at",0.595453032706696,0.0721840457390029,1.88805276939534,-4.33823948429697,0.914963852388414,"KMT2A","lysine methyltransferase 2A",TRUE
+"1565436_s_at",0.622917527985155,0.0937850488387051,1.7509738592923,-4.54746054241788,0.833919455689733,"KMT2A","lysine methyltransferase 2A",TRUE
+"216624_s_at",0.646860829875544,0.117990728053933,1.62646377015008,-4.72732810663842,0.512260536572532,"KMT2A","lysine methyltransferase 2A",TRUE
+"1559856_s_at",0.679371122350206,0.146696945047399,1.50402399269412,-4.89415264213422,1.35038336130132,"KMT2A","lysine methyltransferase 2A",TRUE
+"212076_at",0.724067243569133,0.201200072469508,1.31729685769578,-5.12809112674342,0.414703309311431,"KMT2A","lysine methyltransferase 2A",TRUE
+"212078_s_at",0.73759219552868,0.224348373159409,1.24998131910385,-5.20604041280048,0.39362175581522,"KMT2A","lysine methyltransferase 2A",TRUE
+"244110_at",0.839519981963042,0.427756473021883,0.807865880546873,-5.62670636314573,0.45385208454754,"KMT2A","lysine methyltransferase 2A",TRUE
+"212080_at",0.923376218980614,0.671069100906035,0.430390495797825,-5.84986238347855,0.171191242770906,"KMT2A","lysine methyltransferase 2A",TRUE
+"226981_at",0.973567634886313,0.872854355637717,-0.161896884729086,-5.92692532081266,-0.0601936571345494,"KMT2A","lysine methyltransferase 2A",TRUE
+"229935_s_at",0.980009054680439,0.906053547417312,-0.119375625858244,-5.93274495080449,-0.0497082711757075,"KMT2A","lysine methyltransferase 2A",TRUE
+"203419_at",0.565043084457947,0.0564132660724379,-2.01307644853821,-4.13786096243407,-0.62844358366865,"KMT2B","lysine methyltransferase 2B",TRUE
+"217075_x_at",0.791510606130679,0.322047461252548,1.01288824441983,-5.45196940407402,0.611443456275589,"KMT2B","lysine methyltransferase 2B",TRUE
+"217069_at",0.86333554038125,0.487617719731812,-0.705882107723724,-5.69986582722377,-0.355176575527467,"KMT2B","lysine methyltransferase 2B",TRUE
+"222415_at",0.330153165990401,0.007928494238528,-2.91817071343817,-2.4725803411599,-1.06682630830747,"KMT2C","lysine methyltransferase 2C",TRUE
+"222414_at",0.398650588126476,0.0139370669185446,-2.6699956366904,-2.96021270244919,-0.958008660994158,"KMT2C","lysine methyltransferase 2C",TRUE
+"235859_at",0.766390367856479,0.26697743898437,1.13873297616799,-5.32709857960826,0.377477182397716,"KMT2C","lysine methyltransferase 2C",TRUE
+"232940_s_at",0.841391443291102,0.431985325858475,0.800387120442216,-5.63238724544755,0.274263800637991,"KMT2C","lysine methyltransferase 2C",TRUE
+"222413_s_at",0.903989791603451,0.60601833502203,-0.523214989749907,-5.80722048732518,-0.238858169533877,"KMT2C","lysine methyltransferase 2C",TRUE
+"1557158_s_at",0.979588787486838,0.902656539587015,-0.123714799639647,-5.93223155666194,-0.0371816992741536,"KMT2C","lysine methyltransferase 2C",TRUE
+"227528_s_at",0.425744368467229,0.0180820117580616,-2.55283087608872,-3.18342926041563,-0.714617213702695,"KMT2D","lysine methyltransferase 2D",TRUE
+"231974_at",0.51531387545335,0.0359136509112065,-2.23368990954716,-3.76400576429771,-0.738881750067479,"KMT2D","lysine methyltransferase 2D",TRUE
+"227527_at",0.554323039614776,0.0507268811444669,-2.06589359687426,-4.05062830185027,-0.633785903512388,"KMT2D","lysine methyltransferase 2D",TRUE
+"216845_x_at",0.585892284764425,0.0659194980960146,1.9345203735101,-4.2647935128623,0.547156898150676,"KMT2D","lysine methyltransferase 2D",TRUE
+"211790_s_at",0.596870206986254,0.0730981784358474,-1.8815703186127,-4.34838638989774,-1.14409096137059,"KMT2D","lysine methyltransferase 2D",TRUE
+"216382_s_at",0.758774539184165,0.256005741642987,1.16601772935868,-5.29831917774703,0.335872987098072,"KMT2D","lysine methyltransferase 2D",TRUE
+"226100_at",0.822850703882235,0.388398127535704,-0.879823531495798,-5.56952630348719,-0.316255506769231,"KMT2E","lysine methyltransferase 2E",TRUE
+"223190_s_at",0.835952408568777,0.416904436700768,-0.827271363339024,-5.61173487481076,-0.258383832659343,"KMT2E","lysine methyltransferase 2E",TRUE
+"223189_x_at",0.91671872326659,0.64810094567044,0.462686589549572,-5.83594804640529,0.181509297060739,"KMT2E","lysine methyltransferase 2E",TRUE
+"238473_at",0.942303845415102,0.740577855057776,-0.335266238427886,-5.88508370667264,-0.24108834152726,"KMT2E-AS1","KMT2E antisense RNA 1 (head to head)",TRUE
+"225094_at",0.775805901298839,0.293261629586524,-1.07655564888121,-5.39042621589556,-0.489411204693097,"KMT5A","lysine methyltransferase 5A",TRUE
+"228443_s_at",0.792611633508961,0.324226007235112,-1.00823549521754,-5.45633416341341,-0.47217123312566,"KMT5A","lysine methyltransferase 5A",TRUE
+"225118_at",0.948684674264832,0.766755843726802,0.300289370207416,-5.89585837923601,0.0805761660708324,"KMT5A","lysine methyltransferase 5A",TRUE
+"220200_s_at",0.980067566136987,0.906448224680661,-0.118871637992502,-5.93280339431611,-0.0346405722993168,"KMT5A","lysine methyltransferase 5A",TRUE
+"222566_at",0.667209925683767,0.133725439750828,-1.55664036119675,-4.82372120646676,-0.951325104525234,"KMT5B","lysine methyltransferase 5B",TRUE
+"222759_at",0.819479221404744,0.376800638822196,0.90191833037523,-5.55106008550905,0.366246001870635,"KMT5B","lysine methyltransferase 5B",TRUE
+"218242_s_at",0.848475456105025,0.448816991400866,-0.771059094498144,-5.6541847460488,-0.404007643318701,"KMT5B","lysine methyltransferase 5B",TRUE
+"1570058_at",0.932830928398943,0.703626674014964,-0.385385753512196,-5.86760157385384,-0.151069068082837,"KMT5C","lysine methyltransferase 5C",TRUE
+"224431_s_at",0.942684843065067,0.742914123977687,-0.332127972857556,-5.88609839321078,-0.178863331606898,"KMT5C","lysine methyltransferase 5C",TRUE
+"1564044_at",0.965992617204023,0.841112148118854,-0.202838810970851,-5.91966380366255,-0.102020105713848,"KNCN","kinocilin",TRUE
+"230359_at",0.634202341398092,0.105221210419708,-1.68912179760986,-4.6380631020701,-1.69842763410142,"KNDC1","kinase non-catalytic C-lobe domain containing 1",TRUE
+"230558_at",0.816358096928248,0.367524214021988,0.91991588648855,-5.53570559588663,0.442194381199069,"KNDC1","kinase non-catalytic C-lobe domain containing 1",TRUE
+"233146_at",0.821187434813103,0.382287608517182,0.891410182621737,-5.55989538537464,0.578130583802645,"KNDC1","kinase non-catalytic C-lobe domain containing 1",TRUE
+"217512_at",0.823074246722209,0.389249600661917,0.878218444469832,-5.57085124958766,0.511296853926135,"KNG1","kininogen 1",TRUE
+"206054_at",0.950870395622221,0.775531112061851,0.288651805505239,-5.89918272956802,0.166401165811481,"KNG1","kininogen 1",TRUE
+"243562_at",0.967729052946505,0.848274030023122,0.193572751544376,-5.92144948738172,0.08976523796228,"KNG1","kininogen 1",TRUE
+"1552682_a_at",0.498206796273596,0.0311406324501448,2.30143615155185,-3.64443713282912,0.803781618270846,"KNL1","kinetochore scaffold 1",TRUE
+"1552680_a_at",0.673067408487024,0.138638960299604,1.53623519456452,-4.85126344682519,0.619385050210804,"KNL1","kinetochore scaffold 1",TRUE
+"228323_at",0.774230543658252,0.289375104348622,1.08548819363572,-5.38152295800087,0.410838694693705,"KNL1","kinetochore scaffold 1",TRUE
+"220247_at",0.972112264314695,0.86609736457428,-0.170586115042396,-5.92552005831919,-0.111698381270743,"KNL1","kinetochore scaffold 1",TRUE
+"213235_at",0.740476003158683,0.22918073097705,-1.23660825553345,-5.22110916379678,-0.347918053740145,"KNOP1","lysine rich nucleolar protein 1",TRUE
+"229558_at",0.869441836317963,0.506578452119164,-0.67512947685327,-5.72008573188472,-0.175892904900053,"KNOP1","lysine rich nucleolar protein 1",TRUE
+"213237_at",0.894729774938685,0.57197995608259,-0.573653357022069,-5.78066027156276,-0.185113266584128,"KNOP1","lysine rich nucleolar protein 1",TRUE
+"225300_at",0.784708646973769,0.308648096403311,1.04200104687682,-5.42424664699157,0.323017176697828,"KNSTRN","kinetochore localized astrin/SPAG5 binding protein",TRUE
+"206316_s_at",0.930820302962216,0.693293007728035,0.399578112817297,-5.86221547309271,0.146009625688301,"KNTC1","kinetochore associated 1",TRUE
+"202059_s_at",0.673366993714442,0.139311020433441,-1.53349074879912,-4.85494584886891,-0.57989949752125,"KPNA1","karyopherin subunit alpha 1",TRUE
+"202057_at",0.712187834874413,0.186308598119959,-1.36385800636898,-5.07215857018279,-0.387588543709072,"KPNA1","karyopherin subunit alpha 1",TRUE
+"213741_s_at",0.812302873476553,0.359737721456423,-0.935257614109069,-5.52239636762559,-0.29961950512967,"KPNA1","karyopherin subunit alpha 1",TRUE
+"202056_at",0.835952408568777,0.416506980987299,-0.827988076472827,-5.61117555170282,-0.278963449431879,"KPNA1","karyopherin subunit alpha 1",TRUE
+"202058_s_at",0.870433264908839,0.508854267885862,-0.671482424365552,-5.7224265633307,-0.197813767330718,"KPNA1","karyopherin subunit alpha 1",TRUE
+"202055_at",0.919405960293514,0.657479127536872,-0.449441243046357,-5.84177402157247,-0.131189594672495,"KPNA1","karyopherin subunit alpha 1",TRUE
+"211762_s_at",0.877252641052955,0.526608302368524,0.643337320120935,-5.74008228563414,0.186608394034648,"KPNA2","karyopherin subunit alpha 2",TRUE
+"201088_at",0.928576500287959,0.685951206312619,-0.409712231418892,-5.85825215011499,-0.0926412857303891,"KPNA2","karyopherin subunit alpha 2",TRUE
+"221503_s_at",0.56861088242915,0.0581616437987409,1.99778995123525,-4.1628281121269,0.654072051978494,"KPNA3","karyopherin subunit alpha 3",TRUE
+"221502_at",0.753862100951903,0.24726090005167,1.18839305795862,-5.27427303087857,0.333936038015064,"KPNA3","karyopherin subunit alpha 3",TRUE
+"209653_at",0.358427723880268,0.0100617136282475,2.81419157615455,-2.67915198575082,1.01548105592282,"KPNA4","karyopherin subunit alpha 4",TRUE
+"213567_at",0.51470556386048,0.0351637604149336,2.24376748527726,-3.7463540406437,0.900514566282737,"KPNA4","karyopherin subunit alpha 4",TRUE
+"225267_at",0.518141227654622,0.037040869462301,2.21889635031486,-3.7898310734493,0.737878874361947,"KPNA4","karyopherin subunit alpha 4",TRUE
+"225268_at",0.604824625238112,0.0788196882581541,1.84253340672625,-4.40896836672785,0.660313118726288,"KPNA4","karyopherin subunit alpha 4",TRUE
+"1558383_at",0.886828913485525,0.550377296614373,0.606453702842841,-5.76211876595651,0.381716106053634,"KPNA4","karyopherin subunit alpha 4",TRUE
+"206241_at",0.748760747870936,0.241729894250338,1.20285242740496,-5.25852213275893,0.538166631675631,"KPNA5","karyopherin subunit alpha 5",TRUE
+"227934_at",0.893600768892136,0.568783767618075,0.578465561866932,-5.77800243279624,0.274792599594065,"KPNA5","karyopherin subunit alpha 5",TRUE
+"229317_at",0.975514010346705,0.883334688941384,0.148444527281419,-5.92895636178488,0.0682281031223892,"KPNA5","karyopherin subunit alpha 5",TRUE
+"212103_at",0.949038895598021,0.770259020713078,0.295638548567944,-5.89720254739427,0.0814914808080989,"KPNA6","karyopherin subunit alpha 6",TRUE
+"212101_at",0.952613441433926,0.782838903647747,0.278991412058685,-5.90184328122147,0.0824716805361856,"KPNA6","karyopherin subunit alpha 6",TRUE
+"226976_at",0.979388236370534,0.900875917386318,-0.125990247256489,-5.93195501969314,-0.0319371083316877,"KPNA6","karyopherin subunit alpha 6",TRUE
+"212102_s_at",0.997519336907877,0.987411870741494,0.015956548808542,-5.93955946966018,0.00415112977164789,"KPNA6","karyopherin subunit alpha 6",TRUE
+"213803_at",0.562894650172193,0.0555009306043281,2.02122122288555,-4.12450647368605,0.776044282213379,"KPNB1","karyopherin subunit beta 1",TRUE
+"213574_s_at",0.739340500562926,0.226732500604299,1.24335633567383,-5.21352286060046,0.464044742973609,"KPNB1","karyopherin subunit beta 1",TRUE
+"208975_s_at",0.79985507957204,0.335303162771299,-0.984907643825543,-5.47794304357082,-0.252282810966417,"KPNB1","karyopherin subunit beta 1",TRUE
+"213573_at",0.819018525257656,0.374564219890592,0.906230223175542,-5.54740693355518,0.386997762665205,"KPNB1","karyopherin subunit beta 1",TRUE
+"208974_x_at",0.965992617204023,0.840775173402849,0.203275231002541,-5.91957764963294,0.0545912146489709,"KPNB1","karyopherin subunit beta 1",TRUE
+"213507_s_at",0.997321349050865,0.986395048400084,0.0172455881350548,-5.93953862419064,0.00462767842939726,"KPNB1","karyopherin subunit beta 1",TRUE
+"220160_s_at",0.857381762624307,0.472823370797263,-0.730358879342881,-5.68315933682126,-0.239597953219848,"KPTN","kaptin, actin binding protein",TRUE
+"1559204_x_at",0.630603891142543,0.101920997366916,1.7063580766203,-4.61305991902316,0.947674408267749,"KRAS","KRAS proto-oncogene, GTPase",TRUE
+"214352_s_at",0.671498069723584,0.137642458585406,1.54032476803334,-4.84576651418484,0.651617206862156,"KRAS","KRAS proto-oncogene, GTPase",TRUE
+"204009_s_at",0.70215456577829,0.173615546270574,1.40592531197811,-5.02023467654785,0.477828074479126,"KRAS","KRAS proto-oncogene, GTPase",TRUE
+"1559203_s_at",0.71399486949378,0.189056662754192,1.35505089858226,-5.08286305094437,1.14710260686495,"KRAS","KRAS proto-oncogene, GTPase",TRUE
+"204010_s_at",0.727433654259207,0.207819180238296,1.29746213431944,-5.15142021668141,0.732513959003413,"KRAS","KRAS proto-oncogene, GTPase",TRUE
+"236275_at",0.925511384407886,0.677606321902131,-0.421284246364663,-5.85360708153382,-0.207060960868588,"KRBA1","KRAB-A domain containing 1",TRUE
+"1558533_at",0.895999830738594,0.576886110191546,-0.566293092306252,-5.78468381731783,-0.201079404324371,"KRBA2","KRAB-A domain containing 2",TRUE
+"228721_at",0.769847953580141,0.27801807389149,1.11209659744132,-5.35461388220529,0.760441521460371,"KRBOX1","KRAB box domain containing 1",TRUE
+"1556796_at",0.913468969775679,0.637149168246589,-0.478261703099115,-5.82888537056947,-0.354504932219414,"KRBOX1-AS1","KRBOX1 antisense RNA 1",TRUE
+"206583_at",0.830635993561085,0.403583155255223,-0.851533191842292,-5.59254937701903,-0.29754156478791,"KRBOX4","KRAB box domain containing 4",TRUE
+"233329_s_at",0.689848451630875,0.159000522742578,-1.45752338614361,-4.95477885699304,-1.06097010096903,"KRCC1","lysine rich coiled-coil 1",TRUE
+"218303_x_at",0.690823350461169,0.160457264037423,-1.45221299450701,-4.96160430981757,-1.11976375224749,"KRCC1","lysine rich coiled-coil 1",TRUE
+"222585_x_at",0.869082033398093,0.505895042831488,-0.6762264531814,-5.71937927276385,-0.336761252195313,"KRCC1","lysine rich coiled-coil 1",TRUE
+"243029_at",0.651636743353835,0.121078831962371,1.61217207747264,-4.7473256079104,1.445418891675,"KREMEN1","kringle containing transmembrane protein 1",TRUE
+"234843_s_at",0.817436192601926,0.369823532879767,0.91542706114722,-5.53956139764113,0.553229306255822,"KREMEN1","kringle containing transmembrane protein 1",TRUE
+"235370_at",0.872668627020452,0.516490151668415,0.659311871685935,-5.73015023368803,0.527195557389137,"KREMEN1","kringle containing transmembrane protein 1",TRUE
+"224534_at",0.973071267819624,0.870747738971968,0.164604511887257,-5.92649528802739,0.0955814240377082,"KREMEN1","kringle containing transmembrane protein 1",TRUE
+"227250_at",0.980001024522674,0.905087264742391,0.12060966608488,-5.93260080636628,0.0698826836788342,"KREMEN1","kringle containing transmembrane protein 1",TRUE
+"219692_at",0.804988948559952,0.344181462286556,-0.966590893757473,-5.49458722021758,-0.735826325799962,"KREMEN2","kringle containing transmembrane protein 2",TRUE
+"218798_at",0.904832003218088,0.610223914227487,0.51707999161336,-5.81028897849293,0.176005932791099,"KRI1","KRI1 homolog",TRUE
+"227587_at",0.977369242833284,0.891689667508182,0.137740414481379,-5.93044693630993,0.0462485061542228,"KRI1","KRI1 homolog",TRUE
+"204738_s_at",0.768055385305452,0.271231432431545,1.12837612824819,-5.3378655647631,0.291511257231329,"KRIT1","KRIT1, ankyrin repeat containing",TRUE
+"229785_at",0.886023097762234,0.548416327568498,0.609464076656209,-5.76036717416788,0.214224094227797,"KRIT1","KRIT1, ankyrin repeat containing",TRUE
+"216713_at",0.896229101808264,0.580151909153974,-0.561411193327013,-5.78732475744796,-0.153663026537581,"KRIT1","KRIT1, ankyrin repeat containing",TRUE
+"34031_i_at",0.996917497388089,0.984278687905673,-0.0199286253592471,-5.93949004542523,-0.00478639707265316,"KRIT1","KRIT1, ankyrin repeat containing",TRUE
+"203202_at",0.68747436517451,0.156242260087335,-1.46768709187304,-4.94165907500199,-0.611090798354169,"KRR1","KRR1, small subunit processome component homolog",TRUE
+"235038_at",0.752155597823425,0.245312419221079,1.19345891391389,-5.26877355194041,0.329562478635519,"KRR1","KRR1, small subunit processome component homolog",TRUE
+"243930_x_at",0.790817398514927,0.320686089443595,1.015806897496,-5.44922212172219,0.812526470066267,"KRR1","KRR1, small subunit processome component homolog",TRUE
+"232441_at",0.808266620412549,0.351065187571624,0.952609932229072,-5.50709940220486,0.308272810812127,"KRR1","KRR1, small subunit processome component homolog",TRUE
+"203203_s_at",0.863569008901048,0.488764366953666,-0.704003126082541,-5.70112590492749,-0.224511017141863,"KRR1","KRR1, small subunit processome component homolog",TRUE
+"233515_at",0.897024165042344,0.582863121669752,-0.557368774585409,-5.7894947791919,-0.385398302386019,"KRR1","KRR1, small subunit processome component homolog",TRUE
+"205900_at",0.975398143273847,0.881312463856759,0.151037955760634,-5.92857847493026,0.084852915416711,"KRT1","keratin 1",TRUE
+"213287_s_at",0.864370582190408,0.491667583102363,0.69925701489711,-5.70429446948248,0.257178156171317,"KRT10","keratin 10",TRUE
+"207023_x_at",0.86481525165637,0.492538671744334,0.697836119567121,-5.70523910124651,0.227399008247675,"KRT10","keratin 10",TRUE
+"210633_x_at",0.893600768892136,0.568718071629842,0.578564618648757,-5.7779474967101,0.18517588214619,"KRT10","keratin 10",TRUE
+"207811_at",0.901781358899845,0.598977245654566,0.533532213422175,-5.80198075532388,0.408352639594909,"KRT12","keratin 12",TRUE
+"207935_s_at",0.418742943735676,0.0171403147339816,2.57705264191898,-3.13768801232832,3.34772314574654,"KRT13","keratin 13",TRUE
+"209351_at",0.115382560787698,0.00061621779149534,3.9866343090832,-0.229512929103272,6.04456386216097,"KRT14","keratin 14",TRUE
+"204734_at",0.87548954903345,0.522878541733249,0.649206076342478,-5.73646060641116,1.14680078984808,"KRT15","keratin 15",TRUE
+"209800_at",0.328553295786195,0.00776990235851029,2.92693647583702,-2.45502801420084,4.19981751037235,"KRT16","keratin 16",TRUE
+"212236_x_at",0.0263229205696596,2.31092855481236e-05,5.33254045660557,2.65223716403057,5.3613586635569,"KRT17///JUP","keratin 17///junction plakoglobin",TRUE
+"205157_s_at",0.0674096475280111,0.000162744828051165,4.53008613779837,0.943962048934321,6.04994947678425,"KRT17///JUP","keratin 17///junction plakoglobin",TRUE
+"241828_x_at",0.849935057946582,0.452429048073956,0.764853163712073,-5.6586987831972,0.271788484380511,"KRT17P5","keratin 17 pseudogene 5",TRUE
+"201596_x_at",0.943285763650024,0.744829135588456,0.329558110191474,-5.88692226801185,0.125916949966014,"KRT18","keratin 18",TRUE
+"201650_at",0.864079461576774,0.490939136882124,0.700446345182431,-5.70350237651353,0.85106817761001,"KRT19","keratin 19",TRUE
+"228491_at",0.998870448604467,0.995964070635006,0.00511568797161284,-5.93967073418671,0.0039495281034263,"KRT19","keratin 19",TRUE
+"217338_at",0.952644489493803,0.78319600698481,0.278520047974536,-5.90197079926909,0.212879602860924,"KRT19P2","keratin 19 pseudogene 2",TRUE
+"207908_at",0.824399995824329,0.391821825175876,0.873383435986928,-5.57482881631739,0.431653847077157,"KRT2","keratin 2",TRUE
+"213953_at",0.705559553212919,0.177562544674123,1.39258947389448,-5.03683657318071,0.650599570157209,"KRT20","keratin 20",TRUE
+"243998_at",0.717796175748912,0.193486603350479,1.34106358612804,-5.09974448086231,1.47544203110051,"KRT222","keratin 222",TRUE
+"244111_at",0.727822268767891,0.208060853207637,1.29674727784626,-5.1522554124656,1.44317255055505,"KRT222","keratin 222",TRUE
+"218963_s_at",0.948668195792872,0.766555570384553,0.300555456747317,-5.89578084654579,0.522084071894962,"KRT23","keratin 23",TRUE
+"220267_at",0.998047179825832,0.991343442309513,-0.0109726833436519,-5.93962483862561,-0.00783008384125594,"KRT24","keratin 24",TRUE
+"237905_at",0.929948792534665,0.69053812904698,0.403375711521236,-5.86074172819229,0.190208361365964,"KRT25","keratin 25",TRUE
+"240388_at",0.985498770484702,0.930149303628434,0.0886591367453797,-5.93585567408235,0.0834942473963052,"KRT27","keratin 27",TRUE
+"217325_at",0.98428730171779,0.923672846392983,-0.0969052746618612,-5.93511068481435,-0.0422412475825347,"KRT3","keratin 3",TRUE
+"206677_at",0.84961528963151,0.450750630202857,0.767733135377436,-5.65660824934147,0.430931312662549,"KRT31","keratin 31",TRUE
+"207146_at",0.766989207029679,0.268115184005517,-1.13595120715303,-5.32999903370616,-1.00025045512623,"KRT32","keratin 32",TRUE
+"208483_x_at",0.843367280754583,0.437918556938685,-0.789970136460881,-5.64021721186478,-0.309476692451967,"KRT33A","keratin 33A",TRUE
+"207787_at",0.990810941805126,0.955951447050804,0.0558632468398551,-5.93816361599724,0.0297442806342216,"KRT33B","keratin 33B",TRUE
+"216921_s_at",0.917887697142565,0.651287115108098,0.458177266858931,-5.83795009251355,0.351129297919888,"KRT35","keratin 35",TRUE
+"214576_at",0.87889533384278,0.53236489363318,0.63432367506697,-5.74558315535468,0.268989673664031,"KRT36","keratin 36",TRUE
+"207649_at",0.984515877561407,0.924463560201237,0.0958981424166067,-5.93520521967398,0.0568972893631035,"KRT37","keratin 37",TRUE
+"207716_at",0.839519981963042,0.427018404314903,0.809175864485424,-5.62570619061045,0.26469392294983,"KRT38","keratin 38",TRUE
+"214399_s_at",0.651636743353835,0.121032506548052,1.61238420550311,-4.74702978775649,1.29762962253201,"KRT4","keratin 4",TRUE
+"213240_s_at",0.996447592802945,0.982523752640139,0.0221535749730624,-5.93944444230251,0.0407786571305984,"KRT4","keratin 4",TRUE
+"1562628_at",0.892746695408886,0.565738266003524,-0.583063757615229,-5.77544271247444,-0.6588049210712,"KRT40","keratin 40",TRUE
+"1562629_a_at",0.967098323798013,0.84618490017796,0.196273844869765,-5.92093754173008,0.099144087277947,"KRT40","keratin 40",TRUE
+"201820_at",0.112518135066489,0.000586138554903811,4.00710517406351,-0.185363798730799,5.79236851699244,"KRT5","keratin 5",TRUE
+"209125_at",0.0235179401762595,1.93563293631765e-05,5.40626299885538,2.80619221629469,6.32402396116699,"KRT6A","keratin 6A",TRUE
+"209126_x_at",0.0681210092794308,0.000179344393738114,4.49044712636464,0.858497576153034,3.73171395364104,"KRT6B","keratin 6B",TRUE
+"213680_at",0.457032025390949,0.022599393834869,2.45090381487435,-3.37346017612589,2.21172124704957,"KRT6B","keratin 6B",TRUE
+"214580_x_at",0.00923700177636659,4.43224241786476e-06,6.0279840424038,4.07715090952152,6.28415547992461,"KRT6C///KRT6B///KRT6A","keratin 6C///keratin 6B///keratin 6A",TRUE
+"209016_s_at",0.579036829255831,0.0619457381503373,1.9660533465009,-4.21425359072823,2.78621319421308,"KRT7","keratin 7",TRUE
+"214031_s_at",0.609532363331105,0.0817751050922827,1.82332600946213,-4.4384440768933,1.99176183617778,"KRT7","keratin 7",TRUE
+"1558393_at",0.922016101620372,0.667207445095748,0.435787105267566,-5.84760605488622,0.11049141133353,"KRT7","keratin 7",TRUE
+"1558394_s_at",0.941833562132083,0.738996978792252,-0.337391746908743,-5.88439111031279,-0.284232366544727,"KRT7","keratin 7",TRUE
+"231461_at",0.992294016310421,0.963800159783538,-0.0459012511468274,-5.93865732743567,-0.0226583187843739,"KRT71","keratin 71",TRUE
+"1564435_a_at",0.899825513763341,0.593737725538166,-0.541247767278845,-5.79799726944422,-0.41139033176478,"KRT72","keratin 72",TRUE
+"1553537_at",0.66447166133726,0.132383901361624,-1.56231908270886,-4.81600526414874,-0.819653896809624,"KRT73","keratin 73",TRUE
+"237507_at",0.730001121573068,0.212331190422981,1.28422059925911,-5.1668273452554,0.377616142154382,"KRT73","keratin 73",TRUE
+"231583_at",0.835838027302116,0.41535423270087,0.83006921641213,-5.60954886100572,0.239823250528979,"KRT74","keratin 74",TRUE
+"1553539_at",0.956734254923335,0.804000341683995,0.251166181494282,-5.90900399497366,0.13879589505983,"KRT74","keratin 74",TRUE
+"207065_at",0.903021267024792,0.603005147856885,0.527623076420682,-5.80499397091445,0.33186292275065,"KRT75","keratin 75",TRUE
+"207878_at",0.626839388794963,0.0973588480457155,1.73098448314206,-4.57700700712668,0.738451485591339,"KRT76","keratin 76",TRUE
+"237120_at",0.847644062908097,0.446591753198443,0.774897396916998,-5.65137562565225,0.317276501138683,"KRT77","keratin 77",TRUE
+"1553213_a_at",0.740039310225527,0.228441700022091,1.23863944680351,-5.21882940438517,0.722309311184032,"KRT78","keratin 78",TRUE
+"1553212_at",0.985236171081115,0.926503257293112,-0.0933006465284606,-5.9354444802534,-0.04994331730982,"KRT78","keratin 78",TRUE
+"1569909_at",0.614663663463974,0.0854541851184694,1.80023881048378,-4.47357924486412,0.563590198132657,"KRT79","keratin 79",TRUE
+"209008_x_at",0.955892698633978,0.799147305471714,-0.257528760718749,-5.90743246257803,-0.160406618496328,"KRT8","keratin 8",TRUE
+"231849_at",0.955904644595647,0.800646761805943,0.255561749077757,-5.90792247871122,0.30573748723079,"KRT80","keratin 80",TRUE
+"213711_at",0.702630084418366,0.174235518770823,1.40381469383353,-5.022870899595,2.98821933133348,"KRT81","keratin 81",TRUE
+"233158_at",0.522667179791589,0.0385700014383071,2.19946933028688,-3.8235865875625,0.662912321249048,"KRT82","keratin 82",TRUE
+"207669_at",0.897211098401297,0.583322595608064,0.556684629908368,-5.78986053114706,0.499413585804483,"KRT83","keratin 83",TRUE
+"217031_at",0.916107385524794,0.646165729423549,0.465430218471966,-5.83472053408484,0.269899233172171,"KRT84","keratin 84",TRUE
+"207670_at",0.969859842767097,0.855715302334527,0.18396353884394,-5.92321343607218,0.125159393090263,"KRT85","keratin 85",TRUE
+"230116_at",0.730101539866086,0.21284561689767,1.28272474818642,-5.16855938291205,0.443665027117318,"KRT8P12","keratin 8 pseudogene 12",TRUE
+"222060_at",0.908030744859333,0.618497882398694,0.505068260835519,-5.81619461279028,0.211990632223124,"KRT8P12","keratin 8 pseudogene 12",TRUE
+"208188_at",0.722192678020526,0.198519447759858,1.32547432435883,-5.11838599314045,0.942952729193817,"KRT9","keratin 9",TRUE
+"220976_s_at",0.940724219066753,0.73473701557947,0.343127252457499,-5.88250059815435,0.243363531571029,"KRTAP1-1","keratin associated protein 1-1",TRUE
+"220978_at",0.827768017240356,0.39672305667611,0.864227221881488,-5.58230535255515,0.686000318154413,"KRTAP1-3","keratin associated protein 1-3",TRUE
+"234880_x_at",0.954387719376857,0.790135592327249,0.269372675750155,-5.90440304965521,0.124230620738295,"KRTAP1-3","keratin associated protein 1-3",TRUE
+"233533_at",0.736020435324742,0.221149536896932,1.25895523894579,-5.19585059317448,0.72100302426572,"KRTAP1-5","keratin associated protein 1-5",TRUE
+"1560897_a_at",0.916008366263392,0.645519933280814,0.466346594481985,-5.83430895983562,0.149385877164011,"KRTAP10-11","keratin associated protein 10-11",TRUE
+"237853_x_at",0.717937808890208,0.193759631523667,1.34020977770294,-5.10077019656706,0.642912944972798,"KRTAP10-12///KRTAP10-7","keratin associated protein 10-12///keratin associated protein 10-7",TRUE
+"1564803_at",0.863525751448771,0.488359940750754,0.704665558675181,-5.70068203147622,0.399671140720071,"KRTAP11-1","keratin associated protein 11-1",TRUE
+"1564921_at",0.79782885150643,0.331647455887847,0.992546611507501,-5.47091757354977,0.441105363333063,"KRTAP13-1","keratin associated protein 13-1",TRUE
+"234680_at",0.784789297644843,0.308881358434039,-1.04148670547599,-5.42474257416321,-0.601447215726836,"KRTAP17-1","keratin associated protein 17-1",TRUE
+"1556410_a_at",0.957105919915331,0.805729180073802,-0.248902156962406,-5.90955377480426,-0.259886933208219,"KRTAP19-1","keratin associated protein 19-1",TRUE
+"240967_at",0.820293495506061,0.379227570711387,0.897258167314247,-5.55499019156777,0.509868646743132,"KRTAP19-3","keratin associated protein 19-3",TRUE
+"234691_at",0.894205199149904,0.570524996198359,-0.575842252405173,-5.77945398416234,-0.300058711507045,"KRTAP2-1","keratin associated protein 2-1",TRUE
+"234772_s_at",0.519956259865057,0.0375350648742193,2.21253933126033,-3.8008966432451,1.02755307861686,"KRTAP2-2///KRTAP2-1","keratin associated protein 2-2///keratin associated protein 2-1",TRUE
+"220970_s_at",0.500677386446044,0.0319874996985691,2.28875242803373,-3.66698345686431,0.816406354371559,"KRTAP2-3///KRTAP2-4","keratin associated protein 2-3///keratin associated protein 2-4",TRUE
+"1555673_at",0.837368340567858,0.421326073141687,0.819326877674608,-5.61790437397829,0.943354493394208,"KRTAP2-3///KRTAP2-4","keratin associated protein 2-3///keratin associated protein 2-4",TRUE
+"233537_at",0.689848451630875,0.158844053704925,1.45809611317712,-4.95404152119545,0.386033153748974,"KRTAP3-1","keratin associated protein 3-1",TRUE
+"233534_at",0.843475287501313,0.43874552700818,-0.78852514259464,-5.64129572299609,-0.411254558139725,"KRTAP3-2","keratin associated protein 3-2",TRUE
+"233681_at",0.909052380289506,0.622411793299574,-0.499412474748472,-5.8189284181202,-0.400577598751542,"KRTAP3-3","keratin associated protein 3-3",TRUE
+"234635_at",0.767232419466657,0.269246741962201,1.1331931494886,-5.33286858636722,0.91828485107983,"KRTAP4-1","keratin associated protein 4-1",TRUE
+"234633_at",0.897560972979555,0.584557420657244,0.554847336428986,-5.79084061256676,0.498735516556259,"KRTAP4-11","keratin associated protein 4-11",TRUE
+"224269_at",0.925928942104662,0.679065362972341,-0.419256786237733,-5.85443010647052,-0.203123029465856,"KRTAP4-12","keratin associated protein 4-12",TRUE
+"234671_at",0.95877806139143,0.813290012938896,0.239016198144213,-5.9118964196059,0.0874114797060743,"KRTAP4-2","keratin associated protein 4-2",TRUE
+"234678_at",0.603702127972549,0.0781340966516182,1.84707835015256,-4.40196139944645,0.903738601116232,"KRTAP4-3","keratin associated protein 4-3",TRUE
+"234684_s_at",0.712975827977365,0.187317270114477,1.36061354294589,-5.07610874333422,0.850244535686638,"KRTAP4-4","keratin associated protein 4-4",TRUE
+"234637_at",0.861596375509409,0.482210317157529,-0.71477768515769,-5.69385687702492,-0.442207453055651,"KRTAP4-5","keratin associated protein 4-5",TRUE
+"216810_at",0.738814347286957,0.225502219067668,1.24676835299007,-5.20967349732701,0.802193537702108,"KRTAP4-7","keratin associated protein 4-7",TRUE
+"234631_at",0.796466121438385,0.329208824354113,0.997674769254972,-5.46617359520967,0.352984870968358,"KRTAP4-8","keratin associated protein 4-8",TRUE
+"234685_x_at",0.612420348961838,0.0842304470503266,1.80782099254816,-4.46207600255506,0.716034308583821,"KRTAP4-9","keratin associated protein 4-9",TRUE
+"1566218_at",0.748136676097718,0.240123507552525,1.20709844173972,-5.2538654212194,0.689263559496115,"KRTAP5-2","keratin associated protein 5-2",TRUE
+"208532_x_at",0.95442332217412,0.79054841144985,0.268829267762946,-5.90454500214567,0.101606349740375,"KRTAP5-8","keratin associated protein 5-8",TRUE
+"214517_at",0.822232806605564,0.38691658624767,-0.882621811939105,-5.56721104913082,-0.594088541779856,"KRTAP5-9","keratin associated protein 5-9",TRUE
+"1562681_at",0.599805419912392,0.0763005022983766,-1.85940642008333,-4.38289332386209,-1.04536534031414,"KRTAP5-AS1","KRTAP5-1/KRTAP5-2 antisense RNA 1",TRUE
+"1566219_at",0.986342822130003,0.933679052616918,0.0841675777847641,-5.93623362625368,0.0982680428291531,"KRTAP5-AS1","KRTAP5-1/KRTAP5-2 antisense RNA 1",TRUE
+"1564960_at",0.868397087637799,0.503163136642413,0.680619935284129,-5.71653884889339,0.242005551622166,"KRTAP7-1","keratin associated protein 7-1 (gene/pseudogene)",TRUE
+"1564974_at",0.940668681806864,0.73444857102884,-0.34351602914837,-5.88237131096961,-0.113395619105217,"KRTAP8-1","keratin associated protein 8-1",TRUE
+"234679_at",0.835289077598304,0.414432692767575,0.831735563778468,-5.60824363277862,0.608229592931634,"KRTAP9-3","keratin associated protein 9-3",TRUE
+"233640_x_at",0.775805901298839,0.29319059025439,1.07671815618224,-5.39026482816559,0.725629009602141,"KRTAP9-4","keratin associated protein 9-4",TRUE
+"234639_x_at",0.969946179106301,0.857655513617677,0.18146101445008,-5.92365813179509,0.0715311754957741,"KRTAP9-8","keratin associated protein 9-8",TRUE
+"233631_x_at",0.860085676417428,0.479026185396094,0.720042931288616,-5.69026646920688,0.573066011623873,"KRTAP9-8///KRTAP9-2","keratin associated protein 9-8///keratin associated protein 9-2",TRUE
+"220972_s_at",0.595927404748624,0.0723069483877892,1.88717705818234,-4.33961165575489,1.16992593036544,"KRTAP9-9","keratin associated protein 9-9",TRUE
+"224885_s_at",0.630603891142543,0.101545839030247,-1.70834735044749,-4.61016198142839,-0.603042987692943,"KRTCAP2","keratinocyte associated protein 2",TRUE
+"233122_at",0.671298718565642,0.137380016532883,-1.54140586792154,-4.8443114367758,-0.489856811440888,"KRTCAP2","keratinocyte associated protein 2",TRUE
+"235148_at",0.804779510162821,0.343851459373672,0.967265897940764,-5.49397891302386,1.12376953661328,"KRTCAP3","keratinocyte associated protein 3",TRUE
+"230835_at",0.993225426079816,0.967763077679283,-0.0408731817640426,-5.93886981756782,-0.0306923212253891,"KRTDAP","keratinocyte differentiation associated protein",TRUE
+"235252_at",0.463552233135475,0.0236619823258693,2.42970537333093,-3.41246517471551,1.464044518848,"KSR1","kinase suppressor of ras 1",TRUE
+"213769_at",0.594500139507723,0.0713400167409268,1.89410217830063,-4.32874835056689,1.14499040711925,"KSR1","kinase suppressor of ras 1",TRUE
+"213770_at",0.707898177720919,0.179721609244399,1.38539416813017,-5.04573970797735,0.616902004721934,"KSR1","kinase suppressor of ras 1",TRUE
+"213767_at",0.848376789225697,0.448532179381572,0.77154971946404,-5.65382640860252,0.599029898396508,"KSR1","kinase suppressor of ras 1",TRUE
+"1553491_at",0.758722841981575,0.2557878497957,-1.16656828045377,-5.29773231393405,-0.45104686256991,"KSR2","kinase suppressor of ras 2",TRUE
+"230551_at",0.943464796017993,0.747196509051214,-0.32638432123953,-5.88793101552838,-0.188128504649908,"KSR2","kinase suppressor of ras 2",TRUE
+"225642_at",0.996224607226304,0.98114811383204,0.0238977228715031,-5.93940532225935,0.0101295123622887,"KTI12///TXNDC12","KTI12 chromatin associated homolog///thioredoxin domain containing 12",TRUE
+"1562033_at",0.725225714005638,0.203929296030541,1.30905793206031,-5.13781790187777,0.443191152146758,"KTN1","kinectin 1",TRUE
+"200914_x_at",0.921729477898827,0.666403220294693,0.436912649333757,-5.84713198428041,0.158371394670656,"KTN1","kinectin 1",TRUE
+"200915_x_at",0.954577684533304,0.79264823573989,-0.26606647283896,-5.9052623139834,-0.0846168608979845,"KTN1","kinectin 1",TRUE
+"214709_s_at",0.980570785147084,0.90929893695002,0.11523231476859,-5.93321808840442,0.0354510867404461,"KTN1","kinectin 1",TRUE
+"229316_at",0.587626678796111,0.0664808517921865,1.93020177411864,-4.27167153257882,0.802698237966302,"KXD1","KxDL motif containing 1",TRUE
+"200076_s_at",0.859276375962637,0.476140970714876,0.724831556461824,-5.68697931382622,0.274965876824849,"KXD1","KxDL motif containing 1",TRUE
+"218054_s_at",0.887948692739633,0.553443357131801,0.601758136501413,-5.76483417664668,0.330429009164682,"KXD1","KxDL motif containing 1",TRUE
+"1556411_s_at",0.468982266038461,0.0251324744305933,-2.40177988580851,-3.46356569008338,-0.672941534330481,"KY","kyphoscoliosis peptidase",TRUE
+"1564254_at",0.581852599439475,0.0641652233891784,1.94822834493558,-4.24289155993058,0.653862066750709,"KY","kyphoscoliosis peptidase",TRUE
+"1569991_at",0.644844656970274,0.115056452932337,1.64033707012237,-4.70778606972725,0.799776533070581,"KY","kyphoscoliosis peptidase",TRUE
+"244572_at",0.92563477467988,0.678516896771072,0.42001871603732,-5.85412126734119,0.244240591915913,"KY","kyphoscoliosis peptidase",TRUE
+"1570650_at",0.823476629980596,0.390294230970673,0.876252358498277,-5.57247112866719,0.46593738191833,"KYAT1","kynurenine aminotransferase 1",TRUE
+"1570651_at",0.974536463688956,0.875517874181492,0.158475243563442,-5.92745857902647,0.098085032173512,"KYAT1","kynurenine aminotransferase 1",TRUE
+"206037_at",0.994304286761558,0.974099305311823,0.0328360933329125,-5.93915833853117,0.0109665301915278,"KYAT1","kynurenine aminotransferase 1",TRUE
+"209472_at",0.966051687342135,0.84156722830737,0.202249495054827,-5.91977984831583,0.091949980897482,"KYAT3","kynurenine aminotransferase 3",TRUE
+"210662_at",0.743474458360704,0.233671462483103,1.22437154339073,-5.23477505415688,1.34570566208025,"KYNU","kynureninase",TRUE
+"204385_at",0.76524135343539,0.2654319641949,1.14252563191917,-5.32313403645656,1.16321153055983,"KYNU","kynureninase",TRUE
+"210663_s_at",0.970540753946729,0.859915971530706,0.178546923187088,-5.92416831088665,0.323461685700433,"KYNU","kynureninase",TRUE
+"217388_s_at",0.974884920935236,0.877152226425186,0.156376663508258,-5.9277800180523,0.316810383027759,"KYNU","kynureninase",TRUE
+"204585_s_at",0.326089462713281,0.00750560918200078,2.94193221492214,-2.42495334777854,2.71708381392179,"L1CAM","L1 cell adhesion molecule",TRUE
+"204584_at",0.515919802381527,0.0362158244451816,2.22968318537144,-3.7710105897399,2.28140690944023,"L1CAM","L1 cell adhesion molecule",TRUE
+"236894_at",0.756952614607938,0.252586253351275,1.17469828883668,-5.28903784882068,1.10751237268246,"L1TD1","LINE1 type transposase domain containing 1",TRUE
+"219955_at",0.837345289209351,0.420218310622599,0.821312289521869,-5.61636777652397,0.46347368179373,"L1TD1","LINE1 type transposase domain containing 1",TRUE
+"224459_at",0.360736459722853,0.0103467535711465,2.80192375034116,-2.70331723850901,1.48804064089645,"L2HGDH","L-2-hydroxyglutarate dehydrogenase",TRUE
+"220089_at",0.830960037055612,0.404820636431175,-0.849258104692074,-5.59437043541468,-0.285533651324088,"L2HGDH","L-2-hydroxyglutarate dehydrogenase",TRUE
+"224460_s_at",0.957289701021675,0.806747628164767,-0.247569056880752,-5.90987518072389,-0.102954250693887,"L2HGDH","L-2-hydroxyglutarate dehydrogenase",TRUE
+"227699_at",0.630603891142543,0.101790084997694,1.7070515297306,-4.6120499966961,0.824333107644266,"L3HYPDH","trans-L-3-hydroxyproline dehydratase",TRUE
+"206822_s_at",0.587626678796111,0.0668013804286943,1.92775025950493,-4.27557122265685,1.71222436462538,"L3MBTL1","l(3)mbt-like 1 (Drosophila)",TRUE
+"213837_at",0.59250603410683,0.0696052356116721,1.90673531776644,-4.30885939415603,1.19971321223629,"L3MBTL1","l(3)mbt-like 1 (Drosophila)",TRUE
+"210306_at",0.646692716816097,0.11773841904692,1.62764524485991,-4.72566884779656,1.18876959582121,"L3MBTL1","l(3)mbt-like 1 (Drosophila)",TRUE
+"216077_s_at",0.693742297578797,0.162897321652216,1.44340460491901,-4.97288102666744,0.783125129425908,"L3MBTL1","l(3)mbt-like 1 (Drosophila)",TRUE
+"216076_at",0.697172073261335,0.167048504167262,1.42866046654865,-4.99163146939804,0.773226939781459,"L3MBTL1","l(3)mbt-like 1 (Drosophila)",TRUE
+"206823_at",0.825648186672984,0.393082760461726,0.871020777128328,-5.57676506268711,0.334924788596815,"L3MBTL1","l(3)mbt-like 1 (Drosophila)",TRUE
+"1555815_a_at",0.763445200592777,0.263194852967046,-1.14804449741436,-5.31734431827144,-0.386405213113035,"L3MBTL2","L3MBTL2 polycomb repressive complex 1 subunit",TRUE
+"223205_s_at",0.834265235157814,0.412190747749011,-0.835799304331228,-5.60505029575309,-0.259686002286934,"L3MBTL2","L3MBTL2 polycomb repressive complex 1 subunit",TRUE
+"229393_at",0.55074985379986,0.048889165851303,2.08409787851697,-4.02022040119206,1.07806250152771,"L3MBTL3","l(3)mbt-like 3 (Drosophila)",TRUE
+"1554699_at",0.635368778245437,0.106453013215169,1.68280579449601,-4.64717725889419,0.874763484067868,"L3MBTL4","l(3)mbt-like 4 (Drosophila)",TRUE
+"228557_at",0.969882914559333,0.856339789601886,0.183157931899844,-5.92335725413249,0.160034832034615,"L3MBTL4","l(3)mbt-like 4 (Drosophila)",TRUE
+"240264_at",0.925849603315569,0.678990243148502,-0.419361127847765,-5.85438784542699,-0.309312899455058,"L3MBTL4-AS1","L3MBTL4 antisense RNA 1",TRUE
+"1553141_at",0.296090407530139,0.00532012165396439,3.08992011080494,-2.12511617542346,1.03165314462335,"LACC1","laccase domain containing 1",TRUE
+"228937_at",0.304824368772306,0.00594910337746825,3.04208591608331,-2.22261264547568,1.45059605965856,"LACC1","laccase domain containing 1",TRUE
+"1553142_at",0.358427723880268,0.0101057270794039,2.81227588036285,-2.68292850938056,1.4763405527483,"LACC1","laccase domain containing 1",TRUE
+"1563671_at",0.746784084367898,0.238697734950405,1.2108850136928,-5.24970058351534,0.519583228364572,"LACE1","lactation elevated 1",TRUE
+"1552490_at",0.969859663161336,0.855676093855995,0.184014123085924,-5.92320438471177,0.0852196556113407,"LACE1","lactation elevated 1",TRUE
+"224540_at",0.59411810156079,0.071076845035375,-1.89600122456803,-4.3257644876393,-0.753979910844316,"LACRT","lacritin",TRUE
+"226354_at",0.823074246722209,0.389109228188533,-0.878482899141432,-5.57063310549701,-0.393338530470478,"LACTB","lactamase beta",TRUE
+"1552486_s_at",0.87579870142401,0.523673554331336,-0.647953210923693,-5.73723641612218,-0.286673005644424,"LACTB","lactamase beta",TRUE
+"1552485_at",0.945498722604777,0.754373067746194,-0.31678386705603,-5.89092356319641,-0.124968690268666,"LACTB","lactamase beta",TRUE
+"218701_at",0.901705783008694,0.598597404665451,-0.534090449370131,-5.80169440889535,-0.276658087258339,"LACTB2","lactamase beta 2",TRUE
+"222714_s_at",0.932830928398943,0.703756512658557,-0.385207949591647,-5.86766783428697,-0.192540664382724,"LACTB2","lactamase beta 2",TRUE
+"1559264_at",0.88698237223329,0.550895502522975,0.605659125155481,-5.7625796963246,0.438510810021531,"LACTB2-AS1","LACTB2 antisense RNA 1",TRUE
+"216641_s_at",0.728971609714603,0.210445137407139,1.28972892737984,-5.16043447452731,1.05224395734128,"LAD1","ladinin 1",TRUE
+"203287_at",0.754513748034606,0.247857295209425,1.18684846553549,-5.27594578070961,0.798387409825262,"LAD1","ladinin 1",TRUE
+"206486_at",0.808458051972735,0.351462998396707,0.951807681594255,-5.5078123103233,0.71574937552275,"LAG3","lymphocyte activating 3",TRUE
+"219061_s_at",0.508488499910913,0.0335727527705244,-2.26581447793712,-3.70757142244573,-1.22276335117366,"LAGE3","L antigen family member 3",TRUE
+"221982_x_at",0.937113154905832,0.719820802446906,0.363304343950787,-5.87559967581992,0.155811943103775,"LAGE3","L antigen family member 3",TRUE
+"208071_s_at",0.940301848276502,0.73316578969107,-0.345245666260816,-5.88179436800731,-0.160838205359104,"LAIR1","leukocyte associated immunoglobulin like receptor 1",TRUE
+"210644_s_at",0.976422537443518,0.888050316879559,-0.1424009251618,-5.92981162684075,-0.0588813747826364,"LAIR1","leukocyte associated immunoglobulin like receptor 1",TRUE
+"207509_s_at",0.997056683282451,0.985056768006253,-0.0189421901560631,-5.93950872081003,-0.0134928433368335,"LAIR2","leukocyte associated immunoglobulin like receptor 2",TRUE
+"207816_at",0.863243647327548,0.487385988962061,-0.706262148452673,-5.69961057614896,-0.4051855852951,"LALBA","lactalbumin alpha",TRUE
+"227048_at",0.630603891142543,0.101851883608081,1.70672408316556,-4.61252691746167,1.53211342112851,"LAMA1","laminin subunit alpha 1",TRUE
+"222346_at",0.869082033398093,0.505791343715081,-0.67639297891208,-5.71927193328908,-0.388695575738141,"LAMA1","laminin subunit alpha 1",TRUE
+"205116_at",0.6772176958801,0.144736474709582,1.51172471838295,-4.88396509846965,0.783354944266421,"LAMA2","laminin subunit alpha 2",TRUE
+"216840_s_at",0.683805950121197,0.152564836224737,1.48146649562929,-4.9237542422498,1.0801923866306,"LAMA2","laminin subunit alpha 2",TRUE
+"213519_s_at",0.697699759202153,0.168447378613255,1.42375828776545,-4.9978307713133,0.714190890857944,"LAMA2","laminin subunit alpha 2",TRUE
+"216839_at",0.998870448604467,0.996032469372041,-0.00502898930218658,-5.93967116257283,-0.004374982286377,"LAMA2","laminin subunit alpha 2",TRUE
+"203726_s_at",0.0657210807339444,0.000154600118333728,4.55104496947115,0.989127029817302,5.21731066078056,"LAMA3","laminin subunit alpha 3",TRUE
+"234608_at",0.433660982257499,0.0195918906633589,2.51635293028094,-3.25190054124991,2.04987556849806,"LAMA3","laminin subunit alpha 3",TRUE
+"1568879_a_at",0.673366993714442,0.139304430730036,1.53351760578211,-4.85490983841911,1.13981747321432,"LAMA3","laminin subunit alpha 3",TRUE
+"1563772_a_at",0.709330737815705,0.182084259812408,1.37759863513029,-5.05534236952118,0.465756119522503,"LAMA3","laminin subunit alpha 3",TRUE
+"234719_at",0.802268377942344,0.340031126533187,0.975112611595429,-5.4868790935417,0.780084355097909,"LAMA3","laminin subunit alpha 3",TRUE
+"1560078_at",0.81727813269668,0.369707179807718,0.915653764064897,-5.53936708169168,0.441021602799307,"LAMA3","laminin subunit alpha 3",TRUE
+"210089_s_at",0.0115189490712456,6.25082223170596e-06,5.88147811016728,3.7823919431695,2.66051975364299,"LAMA4","laminin subunit alpha 4",TRUE
+"210990_s_at",0.0127315635396743,7.45148666245225e-06,5.80698453273805,3.63134545215197,3.0615778952923,"LAMA4","laminin subunit alpha 4",TRUE
+"202202_s_at",0.0585007409495706,0.000116626991559272,4.66618710055175,1.23690479105697,4.7527105596076,"LAMA4","laminin subunit alpha 4",TRUE
+"210989_at",0.62282585384278,0.0932707398737865,1.7539040256227,-4.5431083623311,0.742549738182091,"LAMA4","laminin subunit alpha 4",TRUE
+"216081_at",0.774230543658252,0.289575418264199,1.08502570339284,-5.38198554329015,0.451848069161883,"LAMA4","laminin subunit alpha 4",TRUE
+"210150_s_at",0.750807729565285,0.243878781625526,1.19720552270155,-5.26469314601942,0.566461212767521,"LAMA5","laminin subunit alpha 5",TRUE
+"242987_x_at",0.961395512423249,0.825024004860527,0.223721438842833,-5.9153347074033,0.0916016762884402,"LAMA5-AS1","LAMA5 antisense RNA 1",TRUE
+"229570_at",0.407748633394319,0.0156922298492713,-2.61684941549774,-3.06206953707313,-1.13124028591493,"LAMA5-AS1///LAMA5","LAMA5 antisense RNA 1///laminin subunit alpha 5",TRUE
+"201505_at",0.56861088242915,0.0585382054020025,1.99455107536172,-4.16810174165971,2.15911704092679,"LAMB1","laminin subunit beta 1",TRUE
+"211651_s_at",0.615741555799144,0.0862094487360302,1.79560593595122,-4.48059071496874,2.25367620613561,"LAMB1","laminin subunit beta 1",TRUE
+"216264_s_at",0.765214672765218,0.265120467237156,-1.14329202418103,-5.32233150013646,-0.701086198576725,"LAMB2","laminin subunit beta 2",TRUE
+"230616_at",0.986421906591669,0.936678571898616,0.0803521266971532,-5.93653926426617,0.0317209356597168,"LAMB2P1","laminin subunit beta 2 pseudogene 1",TRUE
+"209270_at",0.117675054637733,0.00063834833949174,3.97219683548798,-0.260640271230048,4.84072087377888,"LAMB3","laminin subunit beta 3",TRUE
+"216622_at",0.847797601020174,0.447300008974735,-0.773674471871064,-5.65227207108908,-0.378060792860577,"LAMB4","laminin subunit beta 4",TRUE
+"215516_at",0.92346045063848,0.671543618461886,-0.429728262819395,-5.85013736156412,-0.206986730256751,"LAMB4","laminin subunit beta 4",TRUE
+"234334_s_at",0.978951900396372,0.897694413970488,-0.13005757844291,-5.93144817742056,-0.0734263588259942,"LAMB4","laminin subunit beta 4",TRUE
+"200771_at",0.677013732819214,0.143932739719568,1.51490648139545,-4.87974370003647,1.17538884033178,"LAMC1","laminin subunit gamma 1",TRUE
+"200770_s_at",0.692690388817576,0.162140861382484,1.44612390891026,-4.96940567005075,1.11418481477502,"LAMC1","laminin subunit gamma 1",TRUE
+"207517_at",0.022059692523214,1.65422477083086e-05,5.47178053345985,2.94248239596084,5.29330697560501,"LAMC2","laminin subunit gamma 2",TRUE
+"202267_at",0.0277242942311338,2.6874944567903e-05,5.26988551756951,2.52091667891414,5.95577041252524,"LAMC2","laminin subunit gamma 2",TRUE
+"219407_s_at",0.870433264908839,0.508709351605709,0.671714383355626,-5.72227804372954,0.479232210474629,"LAMC3","laminin subunit gamma 3",TRUE
+"232558_at",0.916008366263392,0.645429025703242,0.466475623638746,-5.83425094497918,0.138382392098067,"LAMC3","laminin subunit gamma 3",TRUE
+"201551_s_at",0.610455440146151,0.0829082406873957,1.81612109663571,-4.44944351918269,0.916376490895191,"LAMP1","lysosomal associated membrane protein 1",TRUE
+"201552_at",0.723973974120865,0.200832988435987,1.31841163516828,-5.12677107565998,0.508594421056058,"LAMP1","lysosomal associated membrane protein 1",TRUE
+"213728_at",0.757479140651,0.25352335701239,1.17231074777791,-5.29159663354403,0.547179399142557,"LAMP1","lysosomal associated membrane protein 1",TRUE
+"201553_s_at",0.820536502908875,0.379919408034066,0.895933305903234,-5.5561040638493,0.306563169713868,"LAMP1","lysosomal associated membrane protein 1",TRUE
+"203042_at",0.735413789306046,0.220481838896946,-1.2608408983657,-5.19370149745493,-0.531446689252721,"LAMP2","lysosomal associated membrane protein 2",TRUE
+"203041_s_at",0.776523469860097,0.293921412140004,-1.07504769835938,-5.39192273940669,-0.467800415344326,"LAMP2","lysosomal associated membrane protein 2",TRUE
+"200821_at",0.78695087282981,0.312837260557035,-1.0328054135336,-5.43307978381737,-0.399944288953588,"LAMP2","lysosomal associated membrane protein 2",TRUE
+"226671_at",0.909897550816198,0.624937774636486,-0.495771070601776,-5.82067263880791,-0.308672187129188,"LAMP2","lysosomal associated membrane protein 2",TRUE
+"205569_at",0.330171916405281,0.00798934513770803,2.91485177969703,-2.47922067832504,3.5333760470145,"LAMP3","lysosomal associated membrane protein 3",TRUE
+"219463_at",0.774230543658252,0.290046415230578,1.08393915915994,-5.3830716190047,0.409969889855224,"LAMP5","lysosomal associated membrane protein family member 5",TRUE
+"223009_at",0.602212332334799,0.0771228303796664,-1.85384599883968,-4.39150490003012,-0.656733009569919,"LAMTOR1","late endosomal/lysosomal adaptor, MAPK and MTOR activator 1",TRUE
+"218291_at",0.489834818934298,0.0291885110212701,-2.33192295678485,-3.58994925482245,-1.00104348153347,"LAMTOR2","late endosomal/lysosomal adaptor, MAPK and MTOR activator 2",TRUE
+"217971_at",0.724697226571437,0.202242621628581,-1.31413941810936,-5.13182485548232,-0.447952276528749,"LAMTOR3","late endosomal/lysosomal adaptor, MAPK and MTOR activator 3",TRUE
+"227562_at",0.774230543658252,0.289058781823693,-1.08621899729012,-5.38079164579371,-0.503514311258574,"LAMTOR3","late endosomal/lysosomal adaptor, MAPK and MTOR activator 3",TRUE
+"224890_s_at",0.937409179150458,0.722222699031385,-0.360045133439408,-5.87674075345261,-0.150681092578274,"LAMTOR4","late endosomal/lysosomal adaptor, MAPK and MTOR activator 4",TRUE
+"202300_at",0.579625094592471,0.0624378361846439,-1.96205312467841,-4.22069588518637,-0.678346139364288,"LAMTOR5","late endosomal/lysosomal adaptor, MAPK and MTOR activator 5",TRUE
+"202299_s_at",0.693343936910212,0.162509420237848,-1.44479774822784,-4.97110121145285,-0.508310494272392,"LAMTOR5","late endosomal/lysosomal adaptor, MAPK and MTOR activator 5",TRUE
+"237065_s_at",0.788039658538346,0.314155065525585,-1.02993064671487,-5.43582674414633,-0.429697737754124,"LAMTOR5-AS1","LAMTOR5 antisense RNA 1",TRUE
+"202020_s_at",0.55074985379986,0.0491368593842838,-2.0816088478259,-4.02438820209809,-0.807058834010535,"LANCL1","LanC like 1",TRUE
+"202019_s_at",0.808379811876819,0.35138462933817,-0.951965676968381,-5.5076719535791,-0.341483846543346,"LANCL1","LanC like 1",TRUE
+"222560_at",0.740321726337106,0.228927652989144,1.23730326649439,-5.22032946320189,0.613637353651844,"LANCL2","LanC like 2",TRUE
+"222561_at",0.843257017684317,0.437738838588448,-0.790284386456875,-5.63998241659584,-0.39513131514779,"LANCL2","LanC like 2",TRUE
+"218219_s_at",0.998176217085116,0.991567350316303,-0.0106888556565873,-5.93962783314319,-0.00523697238559606,"LANCL2","LanC like 2",TRUE
+"243856_at",0.422574093216884,0.0176371060870309,2.56412351253811,-3.16213085973401,2.18033563509761,"LANCL3","LanC like 3",TRUE
+"217933_s_at",0.995111934465262,0.977281024195485,0.028801161787166,-5.93927946658817,0.0091120713256263,"LAP3","leucine aminopeptidase 3",TRUE
+"200673_at",0.597654932724127,0.0749843653076794,-1.86841552753494,-4.36890189645341,-0.513258554983871,"LAPTM4A","lysosomal protein transmembrane 4 alpha",TRUE
+"208767_s_at",0.881822289535728,0.538722050572883,-0.624430723945118,-5.75153468770739,-0.347558072870562,"LAPTM4B","lysosomal protein transmembrane 4 beta",TRUE
+"208029_s_at",0.922652183389116,0.669360410446819,-0.432776754795031,-5.84886809114808,-0.289702320088667,"LAPTM4B","lysosomal protein transmembrane 4 beta",TRUE
+"214039_s_at",0.95168059103032,0.778266812288863,-0.285032164221977,-5.90019013464581,-0.14467318597128,"LAPTM4B","lysosomal protein transmembrane 4 beta",TRUE
+"1554679_a_at",0.969155215883113,0.853902409048691,-0.18630293255148,-5.92279223836111,-0.116989614018289,"LAPTM4B","lysosomal protein transmembrane 4 beta",TRUE
+"201720_s_at",0.300851187527495,0.00571887412789718,3.05900375910887,-2.1881911021429,2.72684990218023,"LAPTM5","lysosomal protein transmembrane 5",TRUE
+"201721_s_at",0.700061364939874,0.171600922331942,1.41282567548569,-5.01159316093527,0.910053914010533,"LAPTM5","lysosomal protein transmembrane 5",TRUE
+"1564244_a_at",0.689168483917391,0.158247962297807,-1.46028218899879,-4.95122497877409,-1.03162230609718,"LARGE-AS1","LARGE antisense RNA 1",TRUE
+"1563039_at",0.914588178928864,0.640338082189923,0.473714348681919,-5.83097106193704,0.487499016922879,"LARGE-AS1","LARGE antisense RNA 1",TRUE
+"1562449_s_at",0.91994485246627,0.659257326397589,0.4469390460188,-5.84285598360671,0.159551547199799,"LARGE-AS1","LARGE antisense RNA 1",TRUE
+"1563040_s_at",0.926735112907652,0.68086004115935,-0.416765377667994,-5.85543612004582,-0.386024437844903,"LARGE-AS1","LARGE antisense RNA 1",TRUE
+"215543_s_at",0.123760100530367,0.000716373404933376,-3.92498263072161,-0.362372012713468,-5.14785789227908,"LARGE1","LARGE xylosyl- and glucuronyltransferase 1",TRUE
+"204414_at",0.474859593446097,0.0260947247251971,-2.38431310862531,-3.49536213727648,-2.43859999676259,"LARGE1","LARGE xylosyl- and glucuronyltransferase 1",TRUE
+"227829_at",0.710891923702131,0.184669373431026,1.3691604060523,-5.06568595748387,0.708083101590005,"LARGE2","LARGE xylosyl- and glucuronyltransferase 2",TRUE
+"212137_at",0.602806347163336,0.0773261232595243,-1.85247933476527,-4.39361868515988,-0.494185931456318,"LARP1","La ribonucleoprotein domain family member 1",TRUE
+"212193_s_at",0.867267132647906,0.499518092108389,-0.68650297422715,-5.7127078753636,-0.239120265544534,"LARP1","La ribonucleoprotein domain family member 1",TRUE
+"239663_x_at",0.873230718105642,0.517885308921693,0.657099009455352,-5.73154000927264,0.450397812498997,"LARP1","La ribonucleoprotein domain family member 1",TRUE
+"210966_x_at",0.886783047600321,0.550332612494312,-0.606522236518893,-5.76207898260741,-0.174745521149507,"LARP1","La ribonucleoprotein domain family member 1",TRUE
+"226750_at",0.677509122383198,0.145062571834835,1.51043791550938,-4.8856703478312,0.621409787313539,"LARP1B","La ribonucleoprotein domain family member 1B",TRUE
+"242153_at",0.678893237494272,0.146432335615363,1.50505844614977,-4.89278655069144,0.64271871650313,"LARP1B","La ribonucleoprotein domain family member 1B",TRUE
+"231011_at",0.783686116003587,0.306267759366335,1.04726545876763,-5.4191580458268,0.516878525058623,"LARP1B","La ribonucleoprotein domain family member 1B",TRUE
+"231824_at",0.859675188316647,0.477786359933351,0.722098612386695,-5.68885788314428,0.261493473532159,"LARP1B","La ribonucleoprotein domain family member 1B",TRUE
+"1554038_at",0.870852305833096,0.510599643153883,-0.668691604050986,-5.72420963007772,-0.198966798681015,"LARP1B","La ribonucleoprotein domain family member 1B",TRUE
+"233764_s_at",0.969882914559333,0.85643621694253,0.183033548862818,-5.92337940309569,0.0829512253279923,"LARP1B","La ribonucleoprotein domain family member 1B",TRUE
+"1555384_a_at",0.676468346171966,0.14321974578387,-1.51774123367802,-4.87597672997735,-0.449630498316118,"LARP4","La ribonucleoprotein domain family member 4",TRUE
+"212714_at",0.724067243569133,0.201078031006859,-1.31766730266144,-5.12765257310447,-0.319804515608173,"LARP4","La ribonucleoprotein domain family member 4",TRUE
+"214155_s_at",0.725583196024696,0.204478609037223,-1.30741006198882,-5.13975716380159,-0.343147064360501,"LARP4","La ribonucleoprotein domain family member 4",TRUE
+"238959_at",0.933859583363678,0.707021057533951,-0.380741544390736,-5.8693223951402,-0.125796160219711,"LARP4","La ribonucleoprotein domain family member 4",TRUE
+"238960_s_at",0.996706815530432,0.983508539637537,0.0209050246902868,-5.93947062663364,0.00664740228708993,"LARP4","La ribonucleoprotein domain family member 4",TRUE
+"240005_at",0.724590981430178,0.201868292149241,-1.31527164103134,-5.13048685189315,-0.809080799968596,"LARP4B","La ribonucleoprotein domain family member 4B",TRUE
+"214215_s_at",0.938086209848257,0.725847958072803,0.355133404999605,-5.87844120606836,0.264935371097067,"LARP4B","La ribonucleoprotein domain family member 4B",TRUE
+"208952_s_at",0.96200396340887,0.827370930563342,-0.220668977852601,-5.9159938321811,-0.0588776916514195,"LARP4B","La ribonucleoprotein domain family member 4B",TRUE
+"228196_s_at",0.969829083058377,0.855487565777984,0.184257356677266,-5.92316082673848,0.0547980927089178,"LARP4B","La ribonucleoprotein domain family member 4B",TRUE
+"208953_at",0.970540753946729,0.859509949294537,0.179070233376729,-5.92407729986765,0.0571838039784236,"LARP4B","La ribonucleoprotein domain family member 4B",TRUE
+"208954_s_at",0.9904530450668,0.951935811625119,0.0609622769277307,-5.93787352181898,0.0186093620103414,"LARP4B","La ribonucleoprotein domain family member 4B",TRUE
+"214216_s_at",0.990810941805126,0.95457499506392,0.0576108794830144,-5.93806704096626,0.0397265258699697,"LARP4B","La ribonucleoprotein domain family member 4B",TRUE
+"236565_s_at",0.654038356341937,0.123152413871928,1.60274570096831,-4.76044056343341,1.58525973026403,"LARP6","La ribonucleoprotein domain family member 6",TRUE
+"237818_at",0.670152406964446,0.135833051964456,1.54781323090206,-4.83567103930468,1.06130502433335,"LARP6","La ribonucleoprotein domain family member 6",TRUE
+"218651_s_at",0.673356287352323,0.139155551241542,1.53412465748185,-4.8540957562528,1.41008268903304,"LARP6","La ribonucleoprotein domain family member 6",TRUE
+"241385_at",0.783033755750449,0.305537121996892,-1.04888716282004,-5.41758585526077,-0.437356386931187,"LARP7","La ribonucleoprotein domain family member 7",TRUE
+"212785_s_at",0.855405088766616,0.468046479705834,-0.738357727803417,-5.67758248623523,-0.190949743721269,"LARP7","La ribonucleoprotein domain family member 7",TRUE
+"215246_at",0.941311073534434,0.737467943938683,0.339449062750172,-5.88371661152947,0.097668654176327,"LARP7","La ribonucleoprotein domain family member 7",TRUE
+"217810_x_at",0.870517518639056,0.509419786628509,0.670577585389961,-5.72300544769628,0.286568169088326,"LARS","leucyl-tRNA synthetase",TRUE
+"222427_s_at",0.928295253101366,0.685047647279141,-0.410962442416843,-5.85775644024828,-0.118701343220003,"LARS","leucyl-tRNA synthetase",TRUE
+"223888_s_at",0.946941640414848,0.759040010564567,-0.310556974158217,-5.89281723520561,-0.117679006551421,"LARS","leucyl-tRNA synthetase",TRUE
+"222428_s_at",0.980832655742,0.910104367051559,0.11420436427501,-5.93333288919929,0.0363247225542036,"LARS","leucyl-tRNA synthetase",TRUE
+"204016_at",0.956960361976289,0.805108194922967,0.24971522311799,-5.90935690495948,0.0992900282606914,"LARS2","leucyl-tRNA synthetase 2, mitochondrial",TRUE
+"34764_at",0.969882914559333,0.85711216745891,-0.182161713245646,-5.92353423040062,-0.0681962937978611,"LARS2","leucyl-tRNA synthetase 2, mitochondrial",TRUE
+"235541_at",0.683805950121197,0.152565072648045,-1.48146560111333,-4.92375540895937,-0.441837938299494,"LAS1L","LAS1 like, ribosome biogenesis factor",TRUE
+"208117_s_at",0.95018792835023,0.773506555503327,-0.291333058071309,-5.89842836306327,-0.0933063445810607,"LAS1L","LAS1 like, ribosome biogenesis factor",TRUE
+"200618_at",0.985498770484702,0.929968098930612,-0.0888897669579058,-5.93583573732563,-0.0382430458757597,"LASP1","LIM and SH3 protein 1",TRUE
+"209881_s_at",0.794782404403782,0.326940119934988,-1.0024692661469,-5.46171820818235,-0.526975817923101,"LAT","linker for activation of T-cells",TRUE
+"211005_at",0.924840236476953,0.674900788206565,0.42504857741081,-5.85206864370446,0.206822149803411,"LAT","linker for activation of T-cells",TRUE
+"221581_s_at",0.576685359869221,0.0613865348777113,1.97063330794947,-4.20686669198481,1.7198045355727,"LAT2","linker for activation of T-cells family member 2",TRUE
+"211768_at",0.973493137611142,0.872108748131062,-0.162855068774757,-5.92677395271296,-0.0901093481249999,"LAT2","linker for activation of T-cells family member 2",TRUE
+"219813_at",0.766390367856479,0.266894319804333,1.1389365424813,-5.32688608248455,0.42151096463926,"LATS1","large tumor suppressor kinase 1",TRUE
+"1570425_s_at",0.800342373547779,0.336119437307724,0.983209801297701,-5.47949782055236,0.479015523217705,"LATS1","large tumor suppressor kinase 1",TRUE
+"1570231_at",0.863769633081355,0.489488404546556,0.702817971916019,-5.70191904336104,0.382605558923154,"LATS1","large tumor suppressor kinase 1",TRUE
+"227772_at",0.975196332002567,0.879211051283012,0.1537340637057,-5.92817870351317,0.0572005906004485,"LATS1","large tumor suppressor kinase 1",TRUE
+"230348_at",0.765647257565398,0.265900505288556,-1.14137410158712,-5.32433898327479,-0.799651759378317,"LATS2","large tumor suppressor kinase 2",TRUE
+"227013_at",0.920295529438727,0.660756808408161,0.44483129701692,-5.84376278655256,0.378469231559453,"LATS2","large tumor suppressor kinase 2",TRUE
+"223380_s_at",0.927934056345262,0.683769076370785,0.412732678909439,-5.85705199833925,0.264232088955437,"LATS2","large tumor suppressor kinase 2",TRUE
+"223379_s_at",0.981557175782601,0.91229968143241,-0.111403175422408,-5.93364050945197,-0.0904496293662769,"LATS2","large tumor suppressor kinase 2",TRUE
+"207734_at",0.868245365203247,0.50232237557237,0.681974763754408,-5.71565939217143,0.220463407998057,"LAX1","lymphocyte transmembrane adaptor 1",TRUE
+"228080_at",0.550609303034583,0.048817820037927,2.08481691815965,-4.01901579371332,3.29179558232966,"LAYN","layilin",TRUE
+"1556886_a_at",0.68865058167867,0.15790786177422,1.46153244352384,-4.94961261048635,1.29170749089319,"LAYN","layilin",TRUE
+"1556885_at",0.903278720743155,0.603292712306864,0.527201933606131,-5.80520747513668,0.439555190889879,"LAYN","layilin",TRUE
+"221011_s_at",0.308621629697291,0.00634458879443223,3.01444313478608,-2.27870857104833,2.88999665916222,"LBH","limb bud and heart development",TRUE
+"214461_at",0.844725208094682,0.441605498362511,-0.783540660474468,-5.64500175598614,-0.904839364383188,"LBP","lipopolysaccharide binding protein",TRUE
+"211652_s_at",0.915939421175188,0.645087311145818,-0.466960706187296,-5.83403269868019,-0.261180216550113,"LBP","lipopolysaccharide binding protein",TRUE
+"201795_at",0.914588178928864,0.640187630827847,0.4739286621862,-5.83087320259539,0.192505624886703,"LBR","lamin B receptor",TRUE
+"208380_at",0.919768670323385,0.658801658293634,0.447579963757817,-5.84257941211441,0.124774153543763,"LBX1","ladybird homeobox 1",TRUE
+"244209_at",0.722442821599878,0.199015138751224,-1.3239557091199,-5.12019213540849,-0.659797999206088,"LBX1-AS1","LBX1 antisense RNA 1 (head to head)",TRUE
+"238422_at",0.954723352940649,0.793883313055014,-0.264442437687978,-5.90568053199006,-0.127459442096324,"LBX2-AS1","LBX2 antisense RNA 1",TRUE
+"242006_at",0.63418824799514,0.10501948600545,1.69016209520666,-4.63655945359754,1.22052868932056,"LCA5","LCA5, lebercilin",TRUE
+"244401_at",0.643515428391208,0.114051683966186,1.64515597470169,-4.70096831805391,0.504871246050566,"LCA5","LCA5, lebercilin",TRUE
+"229953_x_at",0.804981342167892,0.344121242075723,0.966714038189484,-5.49447627257934,0.715297034543955,"LCA5","LCA5, lebercilin",TRUE
+"232196_at",0.775351898377291,0.292065851403965,1.0792948455216,-5.38770298284286,0.2811707998579,"LCA5L","LCA5L, lebercilin like",TRUE
+"1553413_at",0.848475456105025,0.448873389443765,0.770961964095902,-5.65425566160109,0.698043070720633,"LCAL1","lung cancer associated lncRNA 1",TRUE
+"216390_at",0.783297797848606,0.305948472646804,-1.04797380181405,-5.41847159869389,-0.330294868899954,"LCAT","lecithin-cholesterol acyltransferase",TRUE
+"204428_s_at",0.868893139603627,0.505316783904463,-0.677155298327987,-5.71878023316163,-0.522290709753269,"LCAT","lecithin-cholesterol acyltransferase",TRUE
+"1560531_at",0.852597429367874,0.458632702243046,0.754263943574995,-5.66632148083948,0.251168892672331,"LCE1B","late cornified envelope 1B",TRUE
+"1559226_x_at",0.748136676097718,0.240153563532414,1.20701880150614,-5.25395289574028,0.305865764946111,"LCE1E","late cornified envelope 1E",TRUE
+"1559224_at",0.813065886130395,0.362829485742721,0.929139578830725,-5.52772814791821,0.315030909771984,"LCE1E","late cornified envelope 1E",TRUE
+"207710_at",0.617775129514679,0.0887868877868041,1.78005486319068,-4.50402979685735,1.31242692643997,"LCE2B","late cornified envelope 2B",TRUE
+"224328_s_at",0.714795139167042,0.190470038713629,1.35056048759409,-5.0882985528604,0.398609860670106,"LCE3D","late cornified envelope 3D",TRUE
+"204891_s_at",0.0229046978931562,1.8013754172944e-05,5.43622194613467,2.8685761861231,3.33984059357895,"LCK","LCK proto-oncogene, Src family tyrosine kinase",TRUE
+"204890_s_at",0.0523352093161926,7.65764379569348e-05,4.83839055672042,1.60609979979588,2.88967996085759,"LCK","LCK proto-oncogene, Src family tyrosine kinase",TRUE
+"226996_at",0.725583196024696,0.204565932243247,1.30714842046212,-5.14006488107261,0.419143637593528,"LCLAT1","lysocardiolipin acyltransferase 1",TRUE
+"221515_s_at",0.916349280948806,0.646726412132221,-0.464634945240013,-5.83507707457192,-0.184925609070687,"LCMT1","leucine carboxyl methyltransferase 1",TRUE
+"229049_at",0.503066995427577,0.0325681104902299,2.2802329755012,-3.68208646160983,1.59769887900595,"LCMT1-AS2","LCMT1 antisense RNA 2",TRUE
+"1558007_s_at",0.779232856140548,0.300433993734664,-1.06029139421024,-5.40646813844846,-0.721392922155194,"LCMT1-AS2","LCMT1 antisense RNA 2",TRUE
+"204012_s_at",0.747587302711183,0.239367157532788,-1.20910504198315,-5.25165977747536,-0.490488015540112,"LCMT2","leucine carboxyl methyltransferase 2",TRUE
+"204013_s_at",0.812302873476553,0.359385568742787,0.935956693907561,-5.52178508258539,0.677212043619682,"LCMT2","leucine carboxyl methyltransferase 2",TRUE
+"207930_at",0.819807973515613,0.377745814121848,-0.90010107393809,-5.55259489105037,-0.58583200982374,"LCN1","lipocalin 1",TRUE
+"238071_at",0.887083096014278,0.551472120542949,0.604775444596792,-5.76309162973971,0.172439522133896,"LCN10","lipocalin 10",TRUE
+"230717_at",0.769393110223875,0.276736604347072,-1.11514816164153,-5.35149086025741,-0.371798854765694,"LCN12","lipocalin 12",TRUE
+"1569532_a_at",0.824058180734384,0.391463431700304,0.874055869900463,-5.57427685266723,0.518405493512163,"LCN15","lipocalin 15",TRUE
+"212531_at",0.406142422607459,0.0153269502743482,2.62743232619776,-3.04186546118753,3.77508847960238,"LCN2","lipocalin 2",TRUE
+"1559864_at",0.784789297644843,0.308956621540316,1.04132080933652,-5.42490248395772,0.540385079407551,"LCN6","lipocalin 6",TRUE
+"239369_at",0.620025427399625,0.0897810146864648,1.77416053971391,-4.51287500670054,0.783668421844388,"LCN8","lipocalin 8",TRUE
+"1569614_s_at",0.651332373348922,0.120905003111845,1.61296840534801,-4.74621494435654,0.863981045777129,"LCN8","lipocalin 8",TRUE
+"1560488_at",0.80997937403114,0.353783583561731,-0.947140046326608,-5.51194921941772,-0.568074977662472,"LCNL1","lipocalin like 1",TRUE
+"1564431_a_at",0.8920930097751,0.564024574370727,0.58565672789733,-5.77399061187633,0.303739654664883,"LCNL1","lipocalin like 1",TRUE
+"228454_at",0.768852835478002,0.27383039665747,1.12210707330739,-5.34434064541968,0.36291206470788,"LCOR","ligand dependent nuclear receptor corepressor",TRUE
+"226520_at",0.88767000285873,0.552202398909458,0.603656972334169,-5.76373854798306,0.188385786599683,"LCOR","ligand dependent nuclear receptor corepressor",TRUE
+"232293_at",0.536559328842429,0.0433966651993704,-2.14242514835699,-3.92164304045619,-0.987871030081378,"LCORL","ligand dependent nuclear receptor corepressor like",TRUE
+"240592_at",0.599810452189742,0.076352954205132,-1.85905019570947,-4.38344556687514,-0.727668075287536,"LCORL","ligand dependent nuclear receptor corepressor like",TRUE
+"235970_at",0.624520459874487,0.0961409892959203,-1.73772479074442,-4.56707220489202,-0.714985225996571,"LCORL","ligand dependent nuclear receptor corepressor like",TRUE
+"208885_at",0.62110896023334,0.0913362283330598,1.76505107960043,-4.52650266416332,1.58621116164476,"LCP1","lymphocyte cytosolic protein 1",TRUE
+"244251_at",0.637485146909712,0.108668576328807,1.67159974554012,-4.66328426173963,0.802468798397068,"LCP2","lymphocyte cytosolic protein 2",TRUE
+"244598_at",0.654068449739549,0.123217284541698,1.60245294693087,-4.76084691777253,1.15032090990615,"LCP2","lymphocyte cytosolic protein 2",TRUE
+"244578_at",0.700061364939874,0.17144981039619,1.41334586098619,-5.01094030702975,1.30615613095957,"LCP2","lymphocyte cytosolic protein 2",TRUE
+"205269_at",0.819193107051406,0.375607608217781,0.904216425886423,-5.54911508025899,0.710558179519064,"LCP2","lymphocyte cytosolic protein 2",TRUE
+"244556_at",0.897024165042344,0.582864974282339,-0.557366015553979,-5.78949625507872,-0.374770244234677,"LCP2","lymphocyte cytosolic protein 2",TRUE
+"205270_s_at",0.937113154905832,0.72017728662023,0.362820366551339,-5.87576976239078,0.238611233639168,"LCP2","lymphocyte cytosolic protein 2",TRUE
+"206945_at",0.67842163564685,0.145892056548631,1.50717534646273,-4.88998864437051,0.463757335162349,"LCT","lactase",TRUE
+"1563899_at",0.677013732819214,0.144544569228334,1.5124831011803,-4.88295955897732,1.40245706139651,"LCTL","lactase like",TRUE
+"222193_at",0.910165867297668,0.626821488765859,0.49305996501725,-5.82196315420122,0.192412731022436,"LDAH","lipid droplet associated hydrolase",TRUE
+"219008_at",0.950720668053893,0.775130776768877,0.28918182371105,-5.8990341583659,0.160202974255125,"LDAH","lipid droplet associated hydrolase",TRUE
+"222192_s_at",0.971867994936839,0.865393568056699,0.171491932042199,-5.92536934940787,0.0874690943979939,"LDAH","lipid droplet associated hydrolase",TRUE
+"35160_at",0.789661545166663,0.317202712185655,-1.02331456723462,-5.4421224311002,-0.520417480703706,"LDB1","LIM domain binding 1",TRUE
+"203451_at",0.854350135157525,0.465199801242551,-0.743147441682058,-5.6742154833452,-0.332161896226989,"LDB1","LIM domain binding 1",TRUE
+"242360_at",0.836359787010497,0.418049869578599,0.825208263671703,-5.61334238743952,0.514523293685366,"LDB2","LIM domain binding 2",TRUE
+"206481_s_at",0.865733085695438,0.495805422079588,0.692520262079965,-5.70875689780889,0.673644083132556,"LDB2","LIM domain binding 2",TRUE
+"216888_at",0.622434989367596,0.0929803582622116,1.75556453677552,-4.54063962042986,0.81771565220896,"LDB3","LIM domain binding 3",TRUE
+"213371_at",0.67622507827427,0.142742280028097,1.51964603732172,-4.87344237014474,1.14779494654102,"LDB3","LIM domain binding 3",TRUE
+"213717_at",0.747587302711183,0.239501402730482,1.20874854043534,-5.25205187411542,0.463648722414335,"LDB3","LIM domain binding 3",TRUE
+"216887_s_at",0.929926126257279,0.690500976201061,0.40342696784242,-5.860721743139,0.20270601713375,"LDB3","LIM domain binding 3",TRUE
+"234130_at",0.932018790587499,0.699442245342992,-0.391122818339575,-5.86544742486247,-0.158760066345119,"LDB3","LIM domain binding 3",TRUE
+"200650_s_at",0.788413816943444,0.314673849029046,1.02880125618088,-5.43690403437617,0.260755756014001,"LDHA","lactate dehydrogenase A",TRUE
+"1553888_at",0.845176959721596,0.442181860467424,-0.782538547827495,-5.6457441675299,-0.289000383873809,"LDHAL6A","lactate dehydrogenase A like 6A",TRUE
+"210712_at",0.726432421917557,0.205317898570757,1.30489893108301,-5.14270836008761,0.947678010823044,"LDHAL6B","lactate dehydrogenase A like 6B",TRUE
+"201030_x_at",0.51470556386048,0.0350888432911853,2.24478501191384,-3.74456910717995,4.8363648080285,"LDHB","lactate dehydrogenase B",TRUE
+"213564_x_at",0.557512088623721,0.0522738528736214,2.05102135203328,-4.07534142898534,5.38014995843829,"LDHB","lactate dehydrogenase B",TRUE
+"207022_s_at",0.908948198134019,0.621675681192897,-0.500474926162734,-5.81841715907647,-0.255630249006388,"LDHC","lactate dehydrogenase C",TRUE
+"229241_at",0.859502367311367,0.4773541076665,-0.722816036961837,-5.68836539335961,-0.817596552654747,"LDHD","lactate dehydrogenase D",TRUE
+"217173_s_at",0.821896104057596,0.384881020321679,0.886477933272334,-5.56400938520189,0.540227558329832,"LDLR","low density lipoprotein receptor",TRUE
+"202067_s_at",0.829272826611461,0.400479975846437,0.857258051778467,-5.58794691647769,0.473612634732511,"LDLR","low density lipoprotein receptor",TRUE
+"202068_s_at",0.843600852223733,0.438916240756074,0.78822705687077,-5.6415179761922,0.421297574381331,"LDLR","low density lipoprotein receptor",TRUE
+"217103_at",0.926209999527899,0.679542444720738,-0.418594228989083,-5.85469821796513,-0.172262800879164,"LDLR","low density lipoprotein receptor",TRUE
+"217005_at",0.94630837494651,0.756935160373771,0.313363815465209,-5.89196825105978,0.188310963082262,"LDLR","low density lipoprotein receptor",TRUE
+"234985_at",0.998347572104896,0.992626159655599,-0.00934671175169133,-5.93964093050652,-0.00557418522542541,"LDLRAD3","low density lipoprotein receptor class A domain containing 3",TRUE
+"207996_s_at",0.147189326785666,0.00101529553770554,-3.7818826507818,-0.669962530701126,-4.37322913499038,"LDLRAD4","low density lipoprotein receptor class A domain containing 4",TRUE
+"209574_s_at",0.700963156261921,0.172657389693981,-1.40919910472802,-5.01613915867206,-0.72319037169393,"LDLRAD4","low density lipoprotein receptor class A domain containing 4",TRUE
+"209573_s_at",0.976371465776674,0.887313218911555,-0.143345234376268,-5.92968033045408,-0.103945457094263,"LDLRAD4","low density lipoprotein receptor class A domain containing 4",TRUE
+"233138_at",0.992376456171815,0.964500682207534,0.0450123581345397,-5.93869668429114,0.0166918653670525,"LDLRAD4","low density lipoprotein receptor class A domain containing 4",TRUE
+"1560181_at",0.498206796273596,0.0310397706522772,2.30296778644001,-3.64170961470227,1.25497489907939,"LDLRAD4-AS1","LDLRAD4 antisense RNA 1",TRUE
+"57082_at",0.776983560547865,0.295918708965048,-1.07049755672248,-5.39642703243744,-0.464129109044118,"LDLRAP1","low density lipoprotein receptor adaptor protein 1",TRUE
+"221790_s_at",0.904204980173804,0.606565553302933,-0.522415574297171,-5.80762232195102,-0.235506054117549,"LDLRAP1","low density lipoprotein receptor adaptor protein 1",TRUE
+"204454_at",0.962125056232529,0.828017053424151,-0.219828994377447,-5.91617363045537,-0.116865314443352,"LDOC1","leucine zipper down-regulated in cancer 1",TRUE
+"223228_at",0.835920985405183,0.415705378933094,-0.829434881049248,-5.61004508416616,-0.2580523007958,"LDOC1L","leucine zipper down-regulated in cancer 1 like",TRUE
+"1552362_a_at",0.900867933475689,0.59683108739515,-0.53668859113034,-5.80035786274082,-0.189600057935737,"LEAP2","liver enriched antimicrobial peptide 2",TRUE
+"206309_at",0.936143408699214,0.71484255909146,0.370072316795349,-5.87319772502369,0.187973822507011,"LECT1","leukocyte cell derived chemotaxin 1",TRUE
+"207409_at",0.697713925841949,0.168611822481404,1.42318416291077,-4.99855566768995,1.07800314580933,"LECT2","leukocyte cell derived chemotaxin 2",TRUE
+"221557_s_at",0.752235160137581,0.245401232740142,-1.19322735308046,-5.26902537801646,-0.615639276655648,"LEF1","lymphoid enhancer binding factor 1",TRUE
+"221558_s_at",0.922168942129244,0.667752197268044,-0.435025028253307,-5.84792635426366,-0.648423613708027,"LEF1","lymphoid enhancer binding factor 1",TRUE
+"210948_s_at",0.990810941805126,0.955580777126637,0.056333855623039,-5.93813790250565,0.0466437560631254,"LEF1","lymphoid enhancer binding factor 1",TRUE
+"243363_at",0.873081085324568,0.51749316382466,-0.657720658058964,-5.73115003897449,-0.257841033564422,"LEF1-AS1","LEF1 antisense RNA 1",TRUE
+"243362_s_at",0.952613441433926,0.782998592739655,0.278780619993646,-5.90190033321774,0.193928827315709,"LEF1-AS1","LEF1 antisense RNA 1",TRUE
+"206268_at",0.97689149311934,0.889899438732389,0.140032563953225,-5.93013711267482,0.145936214370607,"LEFTY1","left-right determination factor 1",TRUE
+"206012_at",0.831875452294783,0.407486479201459,0.844372050301518,-5.59826604148393,0.28852469900329,"LEFTY1///LEFTY2","left-right determination factor 1///left-right determination factor 2",TRUE
+"1564653_s_at",0.835952408568777,0.416556133652423,-0.827899418430611,-5.61124476502826,-0.565116968403039,"LEKR1","leucine, glutamate and lysine rich 1",TRUE
+"1559105_at",0.837368340567858,0.420629443722592,0.820575044292149,-5.61693876970183,0.657886263235243,"LEKR1","leucine, glutamate and lysine rich 1",TRUE
+"231363_at",0.773234064853267,0.284533497722987,-1.09673750494521,-5.37021725314638,-0.494908795667828,"LELP1","late cornified envelope like proline rich 1",TRUE
+"229927_at",0.627053909308516,0.0978662909606126,1.72819725290043,-4.58110682561555,1.00205912726755,"LEMD1","LEM domain containing 1",TRUE
+"1561280_at",0.677013732819214,0.144267721809786,-1.51357861633511,-4.88150630450702,-1.37634421618642,"LEMD1-AS1","LEMD1 antisense RNA 1",TRUE
+"1561281_a_at",0.998870448604467,0.995792787442039,0.00533279778580267,-5.93966962930065,0.00376739256005942,"LEMD1-AS1","LEMD1 antisense RNA 1",TRUE
+"224980_at",0.791211889207316,0.321599517026506,1.01384764252961,-5.45106712698619,0.309428866019335,"LEMD2","LEM domain containing 2",TRUE
+"218604_at",0.686998148149102,0.155653918865317,-1.46987381039323,-4.93882670364774,-0.533780197488186,"LEMD3","LEM domain containing 3",TRUE
+"221115_s_at",0.726696341943087,0.206788562670416,1.30051790303112,-5.14784563670035,0.646988258171563,"LENEP","lens epithelial protein",TRUE
+"232018_at",0.906280556614332,0.612925069703054,0.513150198584638,-5.81223597795828,0.175135903478113,"LENG1","leukocyte receptor cluster member 1",TRUE
+"224673_at",0.972022150098794,0.865886398181285,0.170857622679784,-5.92547496868271,0.0704484279240649,"LENG8","leukocyte receptor cluster member 8",TRUE
+"1554589_at",0.879948283821082,0.534887653255538,0.630390202448671,-5.74796028775192,0.292440571275089,"LENG9","leukocyte receptor cluster member 9",TRUE
+"235096_at",0.462926905857638,0.0235125380442005,-2.43263275823352,-3.40708972403975,-0.930212735223407,"LEO1","LEO1 homolog, Paf1/RNA polymerase II complex component",TRUE
+"207092_at",0.848475456105025,0.448863598355708,-0.770978826070555,-5.65424335116633,-0.234321715375101,"LEP","leptin",TRUE
+"1556919_at",0.903496822752898,0.604644695830426,0.525223223041988,-5.80620838803305,0.198119433610074,"LEPR","leptin receptor",TRUE
+"1556996_at",0.54295328972902,0.0461650726972353,2.11224530338169,-3.97286578884158,1.00849073665476,"LEPROT","leptin receptor overlapping transcript",TRUE
+"227095_at",0.697172073261335,0.167600582646982,-1.42672185598394,-4.99408512597351,-0.767320634953871,"LEPROT","leptin receptor overlapping transcript",TRUE
+"202378_s_at",0.740476003158683,0.229233365523116,1.23646378217801,-5.22127119437781,0.373653463196959,"LEPROT","leptin receptor overlapping transcript",TRUE
+"202377_at",0.986145735582101,0.932230744087533,0.0860103112570937,-5.93608094020249,0.0255602481828028,"LEPROT","leptin receptor overlapping transcript",TRUE
+"211356_x_at",0.73759219552868,0.224100851415825,1.25067220422924,-5.20525814042772,0.48375700396566,"LEPROT///LEPR","leptin receptor overlapping transcript///leptin receptor",TRUE
+"209894_at",0.744400501967131,0.235365807070321,1.21980097136381,-5.23984932638887,0.761691446525406,"LEPROT///LEPR","leptin receptor overlapping transcript///leptin receptor",TRUE
+"1556997_a_at",0.79943091106207,0.334205131628619,-0.987196031344113,-5.4758436201641,-0.994638989649578,"LEPROT///LEPR","leptin receptor overlapping transcript///leptin receptor",TRUE
+"207255_at",0.806649582904638,0.347660550234686,0.959501285959107,-5.50095286074515,0.477096945575032,"LEPROT///LEPR","leptin receptor overlapping transcript///leptin receptor",TRUE
+"211354_s_at",0.830027835645809,0.401768389032763,0.85487769835293,-5.58986407443166,0.504098889873033,"LEPROT///LEPR","leptin receptor overlapping transcript///leptin receptor",TRUE
+"211355_x_at",0.846529455216068,0.444801286764533,0.77799421719589,-5.64909957777223,0.330465475535712,"LEPROT///LEPR","leptin receptor overlapping transcript///leptin receptor",TRUE
+"202595_s_at",0.990810941805126,0.954377246801562,0.0578619684672222,-5.93805292134594,0.0211602893988285,"LEPROTL1","leptin receptor overlapping transcript-like 1",TRUE
+"202594_at",0.992649913032249,0.965561962959197,0.0436657693874884,-5.93875484043346,0.0172168554588694,"LEPROTL1","leptin receptor overlapping transcript-like 1",TRUE
+"222006_at",0.534440871297584,0.0424131493472376,-2.15356623209145,-3.90261815160446,-0.692989427775434,"LETM1","leucine zipper and EF-hand containing transmembrane protein 1",TRUE
+"233439_at",0.705740389674391,0.178143789744203,-1.39064560144334,-5.03924559415417,-1.24618529433485,"LETM1","leucine zipper and EF-hand containing transmembrane protein 1",TRUE
+"218939_at",0.884562540015067,0.543795045246101,0.616581004428751,-5.75619291270871,0.202727118685059,"LETM1","leucine zipper and EF-hand containing transmembrane protein 1",TRUE
+"1557415_s_at",0.41173827666364,0.0163701304069481,-2.59780822530187,-3.09832123252719,-1.50862149082129,"LETM2","leucine zipper and EF-hand containing transmembrane protein 2",TRUE
+"1552546_a_at",0.965992617204023,0.840889173768792,-0.203127583233044,-5.91960681754117,-0.178531042056164,"LETM2","leucine zipper and EF-hand containing transmembrane protein 2",TRUE
+"207170_s_at",0.93973328739493,0.729614596249012,0.350039539348307,-5.88018033911166,0.12332023573361,"LETMD1","LETM1 domain containing 1",TRUE
+"1557016_a_at",0.69910704334777,0.170400656965937,1.41696760266776,-5.00638939810272,0.559382930884071,"LEXM","lymphocyte expansion molecule",TRUE
+"215270_at",0.895758940460776,0.57652972328159,-0.566826679731186,-5.78439382075903,-0.429221440380099,"LFNG","LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase",TRUE
+"228762_at",0.921729477898827,0.66645752298935,0.436836632546311,-5.84716403977682,0.699349227356135,"LFNG","LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase",TRUE
+"201105_at",0.917456746151293,0.650403413240534,0.459426982361026,-5.83739716896794,0.692801239912423,"LGALS1","galectin 1",TRUE
+"223828_s_at",0.92546912174812,0.677029469813819,-0.422086325854534,-5.85328040880782,-0.296286159032345,"LGALS12","galectin 12",TRUE
+"220440_at",0.743914960202193,0.234705680173531,-1.22157872313565,-5.23787760728997,-0.739322865078635,"LGALS13","galectin 13",TRUE
+"220158_at",0.837368340567858,0.421085539848606,0.819757700158452,-5.61757123756142,0.265652799027935,"LGALS14","galectin 14",TRUE
+"208450_at",0.854184492233394,0.464633423454509,0.744102481262514,-5.67354165547702,0.562604188685234,"LGALS2","galectin 2",TRUE
+"1557197_a_at",0.89967769475675,0.590863850747771,-0.545493872811375,-5.79578131789825,-0.442115502443866,"LGALS3","lectin, galactoside binding soluble 3",TRUE
+"208949_s_at",0.961212424803935,0.823958702992836,-0.225107708703087,-5.91503239149659,-0.219495771068761,"LGALS3","lectin, galactoside binding soluble 3",TRUE
+"200923_at",0.279325273101419,0.00453664092389685,3.1577871777432,-1.98590980204554,3.21267228551958,"LGALS3BP","galectin 3 binding protein",TRUE
+"204272_at",0.993083193605528,0.967195055727513,-0.0415938070251778,-5.93884087485178,-0.0237045874227633,"LGALS4","galectin 4",TRUE
+"206400_at",0.814143616628706,0.36511322887299,0.924642840476042,-5.53162646835215,0.584886847328772,"LGALS7B///LGALS7","galectin 7B///galectin 7",TRUE
+"208935_s_at",0.771158062322823,0.280187361232759,-1.10695410946113,-5.35985961537924,-0.783722249595474,"LGALS8","galectin 8",TRUE
+"208933_s_at",0.909253608893833,0.623297629347819,-0.498134694378834,-5.81954189003355,-0.507482235399603,"LGALS8","galectin 8",TRUE
+"210732_s_at",0.942303845415102,0.740720544925281,0.335074467686726,-5.88514598217381,0.331053119964043,"LGALS8","galectin 8",TRUE
+"208936_x_at",0.948887429653996,0.767388303191783,-0.299449219071838,-5.89610273689387,-0.345089635685669,"LGALS8","galectin 8",TRUE
+"208934_s_at",0.984397001287044,0.924009849164196,-0.0964760217092238,-5.93515109746638,-0.0849740742652116,"LGALS8","galectin 8",TRUE
+"210731_s_at",0.991367768700244,0.959665352416267,0.0511487055144452,-5.93840931135443,0.0215078867335139,"LGALS8","galectin 8",TRUE
+"234611_at",0.916349280948806,0.646746992314924,-0.464605760066087,-5.83509014764155,-0.136920787618006,"LGALS8-AS1","LGALS8 antisense RNA 1",TRUE
+"203236_s_at",0.115320909191562,0.000613779324640959,3.98825648246536,-0.226014992358482,2.72021252171516,"LGALS9","galectin 9",TRUE
+"219998_at",0.758438958502277,0.255531852849939,-1.16721555750927,-5.29704203405303,-0.684039431686716,"LGALSL","galectin like",TRUE
+"226188_at",0.773234064853267,0.284613451500831,-1.09655061685131,-5.37040592575681,-0.445645861847751,"LGALSL","galectin like",TRUE
+"206349_at",0.978255630670068,0.894727596081284,-0.133852473382434,-5.93096078752313,-0.205037111353013,"LGI1","leucine rich glioma inactivated 1",TRUE
+"219699_at",0.763682964138466,0.263709819166607,1.14677104179167,-5.31868245116298,0.330435492624769,"LGI2","leucine rich repeat LGI family member 2",TRUE
+"238061_at",0.922253982025599,0.668233430115335,0.434352028873759,-5.8482087567814,0.184498178648275,"LGI3","leucine rich repeat LGI family member 3",TRUE
+"227821_at",0.946727564264032,0.75847297008943,-0.311312877512075,-5.89258934199186,-0.171879713791486,"LGI4","leucine rich repeat LGI family member 4",TRUE
+"242670_at",0.954449231029359,0.791101825547593,-0.268100919466539,-5.90473481944915,-0.125725991575485,"LGI4","leucine rich repeat LGI family member 4",TRUE
+"201212_at",0.930827859648584,0.693423399011441,0.399398517070532,-5.86228482940409,0.350879478290411,"LGMN","legumain",TRUE
+"218326_s_at",0.844790348750798,0.441809514991867,-0.783185848194133,-5.64526471977267,-0.567913338587386,"LGR4","leucine rich repeat containing G protein-coupled receptor 4",TRUE
+"230674_at",0.89316156038085,0.567036169619602,0.581102595036396,-5.77653685014642,0.24769500254312,"LGR4","leucine rich repeat containing G protein-coupled receptor 4",TRUE
+"222596_s_at",0.996261754016157,0.981946649632254,0.0228852646837946,-5.93942839179465,0.0230044074388891,"LGR4","leucine rich repeat containing G protein-coupled receptor 4",TRUE
+"210393_at",0.722937902375896,0.199682794794425,1.32191491833822,-5.12261657105128,0.963250549520485,"LGR5","leucine rich repeat containing G protein-coupled receptor 5",TRUE
+"213880_at",0.987915939622712,0.942288182939851,-0.0732198178629653,-5.93707260359293,-0.087760139234442,"LGR5","leucine rich repeat containing G protein-coupled receptor 5",TRUE
+"227819_at",0.226811031406261,0.00281672958984639,3.35881960964071,-1.56821043705177,1.64268973372947,"LGR6","leucine rich repeat containing G protein-coupled receptor 6",TRUE
+"220393_at",0.640839095542136,0.111348938759817,1.65829807260588,-4.68229725903111,1.7013564937815,"LGSN","lengsin, lens protein with glutamine synthetase domain",TRUE
+"207240_s_at",0.55937703282623,0.0532307219805729,2.04201790636447,-4.09024553518578,1.16401191608201,"LHCGR","luteinizing hormone/choriogonadotropin receptor",TRUE
+"218656_s_at",0.622917527985155,0.0937978674703704,1.75090100392816,-4.54756868615854,2.91355752657323,"LHFP","lipoma HMGIC fusion partner",TRUE
+"231411_at",0.675260084856186,0.141426667551272,1.52492172487831,-4.86640979650282,0.770463086742631,"LHFP","lipoma HMGIC fusion partner",TRUE
+"236048_at",0.731054546207485,0.214042303181488,-1.27925578034409,-5.17256946258611,-0.981723477251453,"LHFPL1","lipoma HMGIC fusion partner-like 1",TRUE
+"212658_at",0.957430653957785,0.807824100158564,0.246160504532943,-5.91021291359761,0.105341926615653,"LHFPL2","lipoma HMGIC fusion partner-like 2",TRUE
+"236761_at",0.894272567245808,0.570671659111535,-0.575621478675915,-5.77957585303109,-0.270550511518868,"LHFPL3","lipoma HMGIC fusion partner-like 3",TRUE
+"240366_at",0.71789173952175,0.193552046824053,-1.34085884645311,-5.09999049313328,-0.838973353032827,"LHFPL3-AS1","LHFPL3 antisense RNA 1",TRUE
+"1554302_s_at",0.79943091106207,0.334356468737182,-0.98688032490709,-5.47613352069147,-0.672276938127489,"LHFPL3-AS1","LHFPL3 antisense RNA 1",TRUE
+"1554301_at",0.893859847265625,0.569327821537287,0.577645458720656,-5.7784569054959,0.366782534998458,"LHFPL3-AS1","LHFPL3 antisense RNA 1",TRUE
+"239656_at",0.622884407938763,0.0933956355972927,1.75319118782955,-4.54416763547444,1.02589349201362,"LHFPL3-AS2","LHFPL3 antisense RNA 2",TRUE
+"228422_at",0.746766793112708,0.238664466394068,-1.21097357177346,-5.24960304342338,-0.885466714865975,"LHFPL4","lipoma HMGIC fusion partner-like 4",TRUE
+"1555043_at",0.977063818674184,0.890554892286616,0.139193254503408,-5.93025115211922,0.138330232208415,"LHFPL5","lipoma HMGIC fusion partner-like 5",TRUE
+"218523_at",0.876278327062923,0.524911420548716,0.646004523305775,-5.73844023857227,0.283844146738097,"LHPP","phospholysine phosphohistidine inorganic pyrophosphate phosphatase",TRUE
+"206230_at",0.861275718491431,0.481491296462506,0.715964876758537,-5.69304951226446,0.89368806568017,"LHX1","LIM homeobox 1",TRUE
+"206140_at",0.358427723880268,0.0100373436986474,-2.81525571318542,-2.67705371665556,-3.28268963138265,"LHX2","LIM homeobox 2",TRUE
+"211219_s_at",0.657015752622694,0.12547847889273,-1.59232786477747,-4.7748654055278,-1.54717003932462,"LHX2","LIM homeobox 2",TRUE
+"221670_s_at",0.747904962117709,0.239798445541957,1.20796024845066,-5.25291851746907,0.379917871005744,"LHX3","LIM homeobox 3",TRUE
+"1553156_at",0.778686132916778,0.29937039314361,1.06268560555007,-5.40412038319176,0.524490263505596,"LHX4","LIM homeobox 4",TRUE
+"232781_at",0.853297110808539,0.460054198316017,-0.751849675027132,-5.66804532614049,-0.366295938934944,"LHX4","LIM homeobox 4",TRUE
+"1553157_at",0.971216837324271,0.862533160021999,0.17517492300833,-5.92474838079306,0.0459457251044952,"LHX4","LIM homeobox 4",TRUE
+"228209_at",0.948882130664959,0.767353496704783,0.299495449841807,-5.89608930833719,0.116933104626812,"LHX4-AS1","LHX4 antisense RNA 1",TRUE
+"208333_at",0.556381379241158,0.0518697400882999,2.05486803856474,-4.06896060242264,0.966997968809766,"LHX5","LIM homeobox 5",TRUE
+"219884_at",0.694819513561858,0.164405670726104,-1.43801266173108,-4.97975631894441,-1.01156426173707,"LHX6","LIM homeobox 6",TRUE
+"224556_s_at",0.724067243569133,0.201410373662585,1.31665891970036,-5.12884610972274,0.737296722716429,"LHX6","LIM homeobox 6",TRUE
+"1569469_a_at",0.822246268085422,0.387038499413743,-0.882391283481874,-5.56740204256635,-1.07162572216821,"LHX8","LIM homeobox 8",TRUE
+"1560253_at",0.812896635201594,0.361827094966232,-0.93111928634775,-5.52600638159775,-0.707097906268992,"LHX9","LIM homeobox 9",TRUE
+"1565407_at",0.838999550222784,0.424613369142364,-0.81345433324685,-5.6224289873477,-0.611308263254877,"LHX9","LIM homeobox 9",TRUE
+"1562736_at",0.879447209955825,0.533790815943763,0.63209915114937,-5.74692925918285,0.918094237117888,"LHX9","LIM homeobox 9",TRUE
+"1565406_a_at",0.94943075115007,0.771613645710645,-0.29384193589031,-5.89771622900798,-0.338200998373003,"LHX9","LIM homeobox 9",TRUE
+"214045_at",0.963458159500472,0.833317993652744,-0.212943622000381,-5.91762171213497,-0.0930196068458997,"LIAS","lipoic acid synthetase",TRUE
+"205266_at",0.506191505604384,0.0331919477498042,2.27123272633202,-3.69800577128619,2.6675367912428,"LIF","leukemia inhibitory factor",TRUE
+"227771_at",0.597654932724127,0.074905688557106,-1.86895843579335,-4.3680572150043,-1.10764940761319,"LIFR","leukemia inhibitory factor receptor alpha",TRUE
+"225571_at",0.603702127972549,0.0783736205642278,-1.84548656421378,-4.40441686605068,-2.01875437272334,"LIFR","leukemia inhibitory factor receptor alpha",TRUE
+"225575_at",0.62110896023334,0.0912512508805716,-1.7655453680846,-4.52576453460527,-1.4916311533292,"LIFR","leukemia inhibitory factor receptor alpha",TRUE
+"205876_at",0.755448399765195,0.249467231051863,-1.1826927547623,-5.28043687754289,-0.821367312609706,"LIFR","leukemia inhibitory factor receptor alpha",TRUE
+"229185_at",0.865345395265289,0.495031349554575,0.69377806649814,-5.70792685786958,0.314887465792394,"LIFR","leukemia inhibitory factor receptor alpha",TRUE
+"1559986_at",0.943464796017993,0.747182027622416,0.326403725156976,-5.88792487759912,0.29500761167712,"LIFR-AS1///MIR3650","LIFR antisense RNA 1///microRNA 3650",TRUE
+"202726_at",0.976371465776674,0.886230198543775,-0.144732953299029,-5.92948581100584,-0.0537733477544187,"LIG1","DNA ligase 1",TRUE
+"204123_at",0.731054546207485,0.214075111702108,-1.2791608854806,-5.17267902970591,-0.668622408627609,"LIG3","DNA ligase 3",TRUE
+"1555169_at",0.737488397392592,0.223721207428617,1.25173300406326,-5.2040563003368,0.652022627681942,"LIG3","DNA ligase 3",TRUE
+"207348_s_at",0.874487622985108,0.520888390504582,-0.6523469631775,-5.73450935649926,-0.223676518951683,"LIG3","DNA ligase 3",TRUE
+"1554599_x_at",0.921388946695144,0.665082679105389,-0.438762044029386,-5.84635042654311,-0.158682171107188,"LIG3","DNA ligase 3",TRUE
+"1554597_at",0.931370027472813,0.696497773647388,-0.395167852009527,-5.86390974619782,-0.142385366464287,"LIG3","DNA ligase 3",TRUE
+"229861_at",0.998870448604467,0.995632622600368,-0.00553581478407731,-5.93966855459101,-0.00251340061677396,"LIG3","DNA ligase 3",TRUE
+"206235_at",0.7717895132349,0.281386744644473,1.1041232691665,-5.3627380794053,0.506686980811553,"LIG4","DNA ligase 4",TRUE
+"227766_at",0.92346045063848,0.671415661931466,0.429906818703083,-5.85006326100626,0.267853921176824,"LIG4","DNA ligase 4",TRUE
+"207872_s_at",0.640067422642767,0.110782487577377,1.66108646512115,-4.67832119645201,0.89010777407174,"LILRA1","leukocyte immunoglobulin like receptor A1",TRUE
+"210660_at",0.808233282592165,0.350239787454182,-0.954276453407177,-5.50561671503361,-0.510691574234959,"LILRA1","leukocyte immunoglobulin like receptor A1",TRUE
+"211101_x_at",0.61760967235709,0.088216626172012,1.78346171780441,-4.49890758865314,1.02606112269061,"LILRA2","leukocyte immunoglobulin like receptor A2",TRUE
+"211102_s_at",0.617775129514679,0.0884969410277559,1.78178469941923,-4.50142988049603,0.958325687210702,"LILRA2","leukocyte immunoglobulin like receptor A2",TRUE
+"207857_at",0.91041003942435,0.627454432658224,0.492149851864289,-5.82239482815962,0.252627473026195,"LILRA2","leukocyte immunoglobulin like receptor A2",TRUE
+"211100_x_at",0.994217597763908,0.973658038728642,0.0333957329302557,-5.93914028602657,0.0143642594464808,"LILRA2","leukocyte immunoglobulin like receptor A2",TRUE
+"206881_s_at",0.804120194657066,0.342783829317006,0.96945271507604,-5.49200551178592,0.303522135522129,"LILRA3","leukocyte immunoglobulin like receptor A3",TRUE
+"210313_at",0.870988083355039,0.511298281177199,0.667575990551633,-5.72492041049297,0.347852224171005,"LILRA4","leukocyte immunoglobulin like receptor A4",TRUE
+"1555634_a_at",0.497725944448536,0.0308004520930392,2.30662029114437,-3.63520101811798,0.66934842292944,"LILRA5","leukocyte immunoglobulin like receptor A5",TRUE
+"215839_at",0.581188830882547,0.063694256509341,1.95196473640041,-4.23690335592268,0.874236333085907,"LILRA5","leukocyte immunoglobulin like receptor A5",TRUE
+"215838_at",0.802255823093278,0.33999645717307,0.975184095715233,-5.48681417315294,0.29712210650086,"LILRA5","leukocyte immunoglobulin like receptor A5",TRUE
+"1555643_s_at",0.857000466967346,0.471612803842954,0.7323814329223,-5.68175464602627,0.701900111892138,"LILRA5","leukocyte immunoglobulin like receptor A5",TRUE
+"208594_x_at",0.710372201621696,0.183216673502374,1.37389065470536,-5.05989412377025,0.899497308687615,"LILRA6","leukocyte immunoglobulin like receptor A6",TRUE
+"211336_x_at",0.819599903198085,0.376948498688963,0.901633847176492,-5.55130054120549,0.418399495034685,"LILRB1","leukocyte immunoglobulin like receptor B1",TRUE
+"207104_x_at",0.904381089098038,0.607137085239975,0.521581007543874,-5.80804118723635,0.165920560432542,"LILRB1","leukocyte immunoglobulin like receptor B1",TRUE
+"210146_x_at",0.62110896023334,0.0917024327149956,1.76292548593812,-4.5296751193518,1.55767831224788,"LILRB2","leukocyte immunoglobulin like receptor B2",TRUE
+"207697_x_at",0.7768734672127,0.294812986485494,1.07301383103702,-5.39393822429147,0.552447289435151,"LILRB2","leukocyte immunoglobulin like receptor B2",TRUE
+"211133_x_at",0.76912869907427,0.274618217909768,1.12021533302579,-5.346288287776,0.62511629368278,"LILRB3","leukocyte immunoglobulin like receptor B3",TRUE
+"210225_x_at",0.870808709484996,0.510020748551086,-0.669616652712648,-5.72361940050793,-0.263943848984073,"LILRB3","leukocyte immunoglobulin like receptor B3",TRUE
+"211135_x_at",0.907972712789305,0.618235174242711,0.505448482992142,-5.81600974930979,0.261750277457511,"LILRB3","leukocyte immunoglobulin like receptor B3",TRUE
+"210784_x_at",0.995025131654789,0.976643164381078,0.0296100292018747,-5.93925645530697,0.0135378739074792,"LILRB3","leukocyte immunoglobulin like receptor B3",TRUE
+"1569504_at",0.388809096545805,0.0128862998408711,-2.7049188968993,-2.89275647108459,-1.719568332336,"LILRB4","leukocyte immunoglobulin like receptor B4",TRUE
+"210152_at",0.705100208997726,0.176923086735067,1.39473388762835,-5.03417579478572,0.39659180924675,"LILRB4","leukocyte immunoglobulin like receptor B4",TRUE
+"206856_at",0.983115194220002,0.917807935227646,-0.104378691000026,-5.93437836405676,-0.0857311720603766,"LILRB5","leukocyte immunoglobulin like receptor B5",TRUE
+"214561_at",0.714590421965913,0.19002158472725,1.35198241292677,-5.08657898933065,0.878265955856265,"LILRP2","leukocyte immunoglobulin-like receptor pseudogene 2",TRUE
+"220519_s_at",0.767728053775839,0.270248331000672,1.13075896289571,-5.33539606017969,0.526173547572895,"LIM2","lens intrinsic membrane protein 2",TRUE
+"222457_s_at",0.716472449896956,0.192453221746386,1.3443037460224,-5.09584695748514,0.725100400880176,"LIMA1","LIM domain and actin binding 1",TRUE
+"222456_s_at",0.724970327905974,0.203032767225476,1.3117548366828,-5.13463964782729,0.654432117895543,"LIMA1","LIM domain and actin binding 1",TRUE
+"217892_s_at",0.761269771869579,0.260381389407133,1.15503454958542,-5.30997599977153,0.551057170696765,"LIMA1","LIM domain and actin binding 1",TRUE
+"232457_at",0.777826511138126,0.296821220942364,1.06844870662882,-5.3984496570179,0.798024560985068,"LIMCH1","LIM and calponin homology domains 1",TRUE
+"212327_at",0.906476756086155,0.613867717654765,0.511780708772057,-5.8129110835561,0.735751074066055,"LIMCH1","LIM and calponin homology domains 1",TRUE
+"212328_at",0.93135451634378,0.695462475331825,0.396591708687754,-5.86336477302377,0.507763429789204,"LIMCH1","LIM and calponin homology domains 1",TRUE
+"212325_at",0.966294390404751,0.842668798070389,0.200823296370565,-5.92005929520122,0.206565607268766,"LIMCH1","LIM and calponin homology domains 1",TRUE
+"222762_x_at",0.756313947022433,0.251365127733857,-1.17781937807227,-5.28568604030674,-0.423587636428731,"LIMD1","LIM domains containing 1",TRUE
+"222353_at",0.932091525948902,0.699961970489372,-0.390409525463706,-5.86571695916052,-0.279182778087891,"LIMD1","LIM domains containing 1",TRUE
+"218850_s_at",0.940298275288372,0.733131690485011,-0.345291658525484,-5.88177898759017,-0.124292748955574,"LIMD1","LIM domains containing 1",TRUE
+"234687_x_at",0.945498722604777,0.754318346907218,0.316856953987619,-5.89090111551543,0.0942903932359904,"LIMD1","LIM domains containing 1",TRUE
+"234743_at",0.979331215001727,0.90010703642006,0.126973006070239,-5.93183402818832,0.101244060017889,"LIMD1","LIM domains containing 1",TRUE
+"233541_at",0.920564553801456,0.662301367870765,0.442662322971321,-5.8446915392497,0.157333196184921,"LIMD1-AS1","LIMD1 antisense RNA 1",TRUE
+"218600_at",0.737897493665289,0.224625890767424,1.24920740124008,-5.20691626031407,0.957519036387731,"LIMD2","LIM domain containing 2",TRUE
+"219541_at",0.860085676417428,0.478968577043746,-0.720138379410593,-5.69020115114851,-0.325279467977665,"LIME1","Lck interacting transmembrane adaptor 1",TRUE
+"208372_s_at",0.71105346200454,0.184895632504839,1.36842631827579,-5.06658330238228,0.552194219830189,"LIMK1","LIM domain kinase 1",TRUE
+"204356_at",0.857148066512338,0.471853337164474,0.731979318913519,-5.68203421341046,0.268228033443357,"LIMK1","LIM domain kinase 1",TRUE
+"204357_s_at",0.953983577550391,0.788657064052874,-0.271319594588839,-5.90389212635328,-0.179183925547884,"LIMK1","LIM domain kinase 1",TRUE
+"202193_at",0.920564553801456,0.662253160719487,-0.442729986027997,-5.84466263330218,-0.313612784203965,"LIMK2","LIM domain kinase 2",TRUE
+"210582_s_at",0.962555471240652,0.829286885994533,-0.218178635950512,-5.91652490140071,-0.141595412250595,"LIMK2","LIM domain kinase 2",TRUE
+"217475_s_at",0.986736327611135,0.938189080765704,0.078431194150657,-5.93668777926316,0.065622353715713,"LIMK2","LIM domain kinase 2",TRUE
+"1570259_at",0.748924337581408,0.242020454261752,1.20208668572522,-5.25936042438994,0.518215036962284,"LIMS1","LIM zinc finger domain containing 1",TRUE
+"1566127_at",0.839781238235762,0.428494070878713,-0.806558136913792,-5.62770330773891,-0.388547641899916,"LIMS1","LIM zinc finger domain containing 1",TRUE
+"1566129_at",0.966051687342135,0.841335474250758,-0.202549600804797,-5.91972079526575,-0.151506053619999,"LIMS1","LIM zinc finger domain containing 1",TRUE
+"220765_s_at",0.565043084457947,0.0562831255823894,2.01423106578159,-4.1359699899057,0.692451967742811,"LIMS2","LIM zinc finger domain containing 2",TRUE
+"207198_s_at",0.64513208805899,0.115989913108042,1.63589175508412,-4.71406166285264,0.554180546857062,"LIMS4///LIMS1","LIM zinc finger domain containing 4///LIM zinc finger domain containing 1",TRUE
+"223800_s_at",0.744931128252932,0.236681127496796,1.21626996544336,-5.24375822507432,0.425246763884706,"LIMS4///LIMS3","LIM zinc finger domain containing 4///LIM zinc finger domain containing 3",TRUE
+"212687_at",0.92247975200053,0.66875232410007,0.433626589114201,-5.8485126833871,0.166100192623469,"LIMS4///LIMS3///LIMS1","LIM zinc finger domain containing 4///LIM zinc finger domain containing 3///LIM zinc finger domain containing 1",TRUE
+"219823_at",0.774230543658252,0.289381473341926,-1.08547348518336,-5.3815376721827,-1.23052621356104,"LIN28A","lin-28 homolog A",TRUE
+"229349_at",0.0115189490712456,6.32041101302913e-06,5.87677676909851,3.77288229108663,4.11929793527914,"LIN28B","lin-28 homolog B",TRUE
+"244175_at",0.705559553212919,0.177631926033457,1.39235717422674,-5.0371246062236,0.815431449051036,"LIN28B-AS1","LIN28B antisense RNA 1",TRUE
+"213526_s_at",0.527826453640453,0.0403265201304613,-2.1779981471654,-3.86068202538795,-0.735428146974654,"LIN37","lin-37 DREAM MuvB core complex component",TRUE
+"232534_at",0.976371465776674,0.88620876452121,0.144760420529126,-5.92948194199121,0.0616635433109343,"LIN37","lin-37 DREAM MuvB core complex component",TRUE
+"228583_at",0.621733119678766,0.0920692122724316,-1.76080384647973,-4.53283887016557,-0.489131569070871,"LIN52","lin-52 DREAM MuvB core complex component",TRUE
+"231959_at",0.839425347843955,0.425297355587223,-0.812236011415334,-5.62336384349804,-0.239217164501692,"LIN52","lin-52 DREAM MuvB core complex component",TRUE
+"235809_at",0.904381089098038,0.607684243266262,0.520782383524597,-5.80844140223305,0.179709691828727,"LIN54","lin-54 DREAM MuvB core complex component",TRUE
+"206440_at",0.48580305784244,0.0283372602597149,-2.34580779562796,-3.56499707964816,-3.36998201900423,"LIN7A","lin-7 homolog A, crumbs cell polarity complex component",TRUE
+"240027_at",0.631492020774022,0.102782761643677,-1.70181205294928,-4.61967297135377,-2.38164151501224,"LIN7A","lin-7 homolog A, crumbs cell polarity complex component",TRUE
+"241652_x_at",0.644809676493259,0.115022016915204,-1.64050163977155,-4.70755349065754,-2.45990489226054,"LIN7A","lin-7 homolog A, crumbs cell polarity complex component",TRUE
+"227929_at",0.816800680706682,0.368909126132253,-0.917209975032068,-5.53803199504521,-1.31825084426348,"LIN7A","lin-7 homolog A, crumbs cell polarity complex component",TRUE
+"241957_x_at",0.451188502303822,0.0216124862831954,-2.47143801706944,-3.3355041187938,-1.11225553799732,"LIN7B","lin-7 homolog B, crumbs cell polarity complex component",TRUE
+"219760_at",0.620437879410052,0.0903053432893497,-1.77107430119735,-4.51749774789784,-0.752089639789633,"LIN7B","lin-7 homolog B, crumbs cell polarity complex component",TRUE
+"219399_at",0.853793505235478,0.46263775921173,0.747473148971504,-5.6711569270546,0.28831934789301,"LIN7C","lin-7 homolog C, crumbs cell polarity complex component",TRUE
+"221568_s_at",0.909304648717545,0.623466166824387,0.497891681539574,-5.81965838865843,0.159890777465773,"LIN7C","lin-7 homolog C, crumbs cell polarity complex component",TRUE
+"223350_x_at",0.914776697425609,0.640972725441428,0.472810565753317,-5.83138326873206,0.12441347921283,"LIN7C","lin-7 homolog C, crumbs cell polarity complex component",TRUE
+"235039_x_at",0.912895919290907,0.634577454203388,-0.481936399727243,-5.82718569472643,-0.169397934315874,"LIN9","lin-9 DREAM MuvB core complex component",TRUE
+"230365_at",0.928075017557587,0.684017173891506,-0.41238907247091,-5.85718896489198,-0.256502904859277,"LIN9","lin-9 DREAM MuvB core complex component",TRUE
+"1552771_a_at",0.973813779781491,0.873627176923313,-0.160903891840695,-5.92708124768389,-0.0855620147152631,"LIN9","lin-9 DREAM MuvB core complex component",TRUE
+"238986_at",0.432151440378733,0.0192921626168069,2.52338027618793,-3.23874913328541,1.1751070117713,"LINC-PINT","long intergenic non-protein coding RNA, p53 induced transcript",TRUE
+"239055_at",0.538508613666048,0.0439998412517637,2.13570470966734,-3.93308907305069,1.23101253655027,"LINC-PINT","long intergenic non-protein coding RNA, p53 induced transcript",TRUE
+"228702_at",0.637485146909712,0.108596476594084,1.6719613616199,-4.66276576733442,1.05360393832843,"LINC-PINT","long intergenic non-protein coding RNA, p53 induced transcript",TRUE
+"243716_at",0.97897951922649,0.898011531738945,0.129652065715639,-5.9314994310915,0.0906444924382761,"LINC-PINT","long intergenic non-protein coding RNA, p53 induced transcript",TRUE
+"233812_at",0.822466887436572,0.387409299213594,0.881690420272611,-5.56798242541988,0.359088816926752,"LINC00028","long intergenic non-protein coding RNA 28",TRUE
+"231760_at",0.843753336849204,0.439434461699457,0.787322619632047,-5.6421918417411,0.558301740435264,"LINC00029","long intergenic non-protein coding RNA 29",TRUE
+"1559293_x_at",0.71242055183987,0.186593189571005,1.36294119673922,-5.07327559229708,0.632929774244116,"LINC00032","long intergenic non-protein coding RNA 32",TRUE
+"1563728_at",0.826140850652187,0.394115071780691,0.869090150787158,-5.57834363139788,0.349599733772366,"LINC00032","long intergenic non-protein coding RNA 32",TRUE
+"1559291_at",0.945498722604777,0.754239496075454,-0.31696227281924,-5.89086875921435,-0.276452812619126,"LINC00032","long intergenic non-protein coding RNA 32",TRUE
+"1559292_s_at",0.95877806139143,0.813076451108435,0.239295096395764,-5.91183162395089,0.172154938789818,"LINC00032","long intergenic non-protein coding RNA 32",TRUE
+"1554976_a_at",0.562643595171948,0.0552287599701967,-2.0236740731032,-4.12047766797677,-1.43556990250842,"LINC00051","long intergenic non-protein coding RNA 51",TRUE
+"1553226_at",0.77766827327863,0.296701603668811,-1.06872000114802,-5.39818203427933,-1.43271664556687,"LINC00052","long intergenic non-protein coding RNA 52",TRUE
+"1562733_at",0.955515814503015,0.796229268666292,0.26135967575298,-5.90646740172425,0.0695806622567776,"LINC00092","long intergenic non-protein coding RNA 92",TRUE
+"203245_s_at",0.545080135838504,0.0468614508036656,-2.10491063965157,-3.98524469458615,-0.731541982120238,"LINC00094","long intergenic non-protein coding RNA 94",TRUE
+"1562916_at",0.980264692225439,0.907709761431527,0.1172609143202,-5.93298852160372,0.0979804103557576,"LINC00102","long intergenic non-protein coding RNA 102",TRUE
+"1560881_a_at",0.505411134618713,0.0330007819037733,2.273974166728,-3.69316074680026,0.775936913698445,"LINC00112","long intergenic non-protein coding RNA 112",TRUE
+"231491_at",0.620223198657182,0.0901083500708317,-1.77223200688594,-4.515764362391,-0.76252290925146,"LINC00113","long intergenic non-protein coding RNA 113",TRUE
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+"1552466_x_at",0.95238233774064,0.782138280183083,-0.279916398584959,-5.90159242272284,-0.248419883700791,"LINC00161","long intergenic non-protein coding RNA 161",TRUE
+"1554405_a_at",0.999357794096444,0.997913820329025,0.00264430014326854,-5.93968007504683,0.00226088331729368,"LINC00161","long intergenic non-protein coding RNA 161",TRUE
+"1562034_at",0.90344422113846,0.604477116752278,0.525468369889933,-5.80608458159169,0.34615436409004,"LINC00163","long intergenic non-protein coding RNA 163",TRUE
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+"1552955_at",0.863769633081355,0.489553766397634,0.702711032848945,-5.70199054732376,0.409253031422742,"LINC00208","long intergenic non-protein coding RNA 208",TRUE
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+"220701_at",0.97794831512468,0.89354158263134,0.135370078643495,-5.93076196007128,0.0577962005088244,"LINC00216","long intergenic non-protein coding RNA 216",TRUE
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+"237205_at",0.928246500493356,0.684808444494122,-0.411293527244324,-5.85762491593596,-0.482126761360517,"LINC00238","long intergenic non-protein coding RNA 238",TRUE
+"1568854_at",0.699391325858549,0.170941921448737,1.4150969029995,-5.00874122606828,1.26299327624202,"LINC00240","long intergenic non-protein coding RNA 240",TRUE
+"1561327_at",0.836712431925572,0.418447287902133,0.82449328435633,-5.61389860360673,0.640467219302844,"LINC00242","long intergenic non-protein coding RNA 242",TRUE
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+"1558425_x_at",0.994145854504594,0.973086091392043,-0.0341211256499186,-5.93911643281732,-0.0261834474071243,"LINC00265","long intergenic non-protein coding RNA 265",TRUE
+"232953_at",0.931528703027792,0.697232346042141,0.394158091049392,-5.86429505638685,0.148775480039101,"LINC00266-1","long intergenic non-protein coding RNA 266-1",TRUE
+"1553457_at",0.588709322600978,0.0675314030987259,1.92220517954788,-4.28437930124727,0.821768279786691,"LINC00269","long intergenic non-protein coding RNA 269",TRUE
+"1561106_at",0.97763916244156,0.892207048552995,0.137078118261105,-5.93053550668216,0.130279612718127,"LINC00271","long intergenic non-protein coding RNA 271",TRUE
+"1569755_at",0.674667400429784,0.140994038000799,1.52666539901429,-4.86408118604596,0.829910962879805,"LINC00276","long intergenic non-protein coding RNA 276",TRUE
+"243384_at",0.934048461921637,0.707986359069495,0.37942237518868,-5.86980743593012,0.118954502707994,"LINC00280","long intergenic non-protein coding RNA 280",TRUE
+"1557465_at",0.863982129426672,0.490530100807732,0.701114620517794,-5.70305674239946,0.263704389623403,"LINC00282","long intergenic non-protein coding RNA 282",TRUE
+"232318_s_at",0.708193186381687,0.180043626716149,-1.38432690629722,-5.04705703345129,-1.54855340738184,"LINC00284","long intergenic non-protein coding RNA 284",TRUE
+"1556099_at",0.765934384067577,0.266212635617754,1.14060780931759,-5.3251402286544,0.753539426970984,"LINC00290","long intergenic non-protein coding RNA 290",TRUE
+"240682_at",0.603853962695872,0.0784059660629973,1.84527193251263,-4.40474783844708,0.703341203422287,"LINC00293","long intergenic non-protein coding RNA 293",TRUE
+"226793_at",0.550815664569158,0.0491632100014188,2.08134471730047,-4.0248302911026,1.0108766928065,"LINC00294","long intergenic non-protein coding RNA 294",TRUE
+"1560413_at",0.512834526570271,0.0343390434709421,2.25507943955978,-3.72648354000105,2.05823493933258,"LINC00298","long intergenic non-protein coding RNA 298",TRUE
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+"1554765_a_at",0.998870448604467,0.995971148356849,-0.00510671661892815,-5.93967077885463,-0.0048408226768144,"LINC00301","long intergenic non-protein coding RNA 301",TRUE
+"216718_at",0.774230543658252,0.287617193167764,-1.08955683086894,-5.37744591137947,-0.732806960566435,"LINC00302","long intergenic non-protein coding RNA 302",TRUE
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+"1553449_at",0.984663371658531,0.924944236031285,0.095285955298574,-5.93526220066058,0.0845637774896151,"LINC00304","long intergenic non-protein coding RNA 304",TRUE
+"1553450_s_at",0.986421906591669,0.936410853769392,0.0806926192161619,-5.93651256473196,0.0551552492596583,"LINC00304","long intergenic non-protein coding RNA 304",TRUE
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+"1563385_at",0.970353888480813,0.858959327809546,0.179779995112233,-5.92395343799808,0.10047560805111,"LINC00307","long intergenic non-protein coding RNA 307",TRUE
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+"1552604_at",0.921603564091029,0.665651310151324,0.437965496007447,-5.84668744657068,0.273429615558921,"LINC00308","long intergenic non-protein coding RNA 308",TRUE
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+"1552856_at",0.682539393883246,0.150293806284811,1.49011153719147,-4.91245208871918,0.837496589283345,"LINC00311","long intergenic non-protein coding RNA 311",TRUE
+"240306_at",0.866812325829005,0.498351689988275,0.688390664427127,-5.71147195491154,0.493187061752685,"LINC00312","long intergenic non-protein coding RNA 312",TRUE
+"220244_at",0.904381089098038,0.60755239221183,0.520974800054706,-5.80834503103404,0.137381510929273,"LINC00312","long intergenic non-protein coding RNA 312",TRUE
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+"1559544_s_at",0.874474734833648,0.520777949902131,0.652521455346708,-5.73440068966219,0.242522421845656,"LINC00441","long intergenic non-protein coding RNA 441",TRUE
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+"1569287_at",0.751579819725748,0.244825958208998,-1.19472836543388,-5.26739224759,-0.809007782192895,"LINC00458","long intergenic non-protein coding RNA 458",TRUE
+"237275_at",0.960614707352139,0.821217961341496,0.228676297834999,-5.91424560936459,0.113449184571267,"LINC00458","long intergenic non-protein coding RNA 458",TRUE
+"240431_at",0.958325326717984,0.811460856056657,-0.241405591856283,-5.91133886259916,-0.144607477474219,"LINC00459","long intergenic non-protein coding RNA 459",TRUE
+"1558930_at",0.156398984165101,0.00119569776645656,3.7145684113997,-0.814157511596839,2.76642642030917,"LINC00460","long intergenic non-protein coding RNA 460",TRUE
+"1563062_at",0.387357699611418,0.012806544354395,2.70767834576702,-2.88740916549028,1.81366329271563,"LINC00460","long intergenic non-protein coding RNA 460",TRUE
+"230272_at",0.918041148686074,0.651922553980531,-0.457279098265106,-5.83834656627469,-0.730063545828908,"LINC00461///MIR9-2","long intergenic non-protein coding RNA 461///microRNA 9-2",TRUE
+"238850_at",0.943400587031071,0.746009205988384,-0.327975634398978,-5.88742644495528,-0.404734564511707,"LINC00461///MIR9-2","long intergenic non-protein coding RNA 461///microRNA 9-2",TRUE
+"241118_at",0.906507435035949,0.614233729259339,0.511249230136303,-5.81317260820378,0.378038217329729,"LINC00462","long intergenic non-protein coding RNA 462",TRUE
+"1569537_at",0.893462835798285,0.568384533237054,-0.579067619926561,-5.77766839575489,-0.282393818289052,"LINC00463","long intergenic non-protein coding RNA 463",TRUE
+"242284_at",0.889389445320988,0.557010172054165,-0.596312787980979,-5.76795765424245,-0.354089679600154,"LINC00466","long intergenic non-protein coding RNA 466",TRUE
+"224444_s_at",0.581502930780773,0.0639533919297764,-1.9499058946133,-4.24020397146156,-0.808537574245148,"LINC00467","long intergenic non-protein coding RNA 467",TRUE
+"224443_at",0.798136642075741,0.332338106768818,-0.991098992044749,-5.47225272277453,-0.503356292458717,"LINC00467","long intergenic non-protein coding RNA 467",TRUE
+"234712_at",0.423421354964585,0.0177842747713812,2.56035884870389,-3.16923644619332,1.59510634310407,"LINC00470","long intergenic non-protein coding RNA 470",TRUE
+"223977_s_at",0.656352758313168,0.124511948957004,1.59663698816573,-4.76890774176672,1.27443111632315,"LINC00470","long intergenic non-protein coding RNA 470",TRUE
+"224181_at",0.720627004277655,0.196701187230722,1.33107031060299,-5.11171544532068,0.761753422448819,"LINC00470","long intergenic non-protein coding RNA 470",TRUE
+"224045_x_at",0.946727564264032,0.75848551589234,0.311296151106303,-5.89259439068377,0.278753291871548,"LINC00470","long intergenic non-protein coding RNA 470",TRUE
+"1552979_at",0.982243328340126,0.914647818304531,-0.108407997028161,-5.93396099236593,-0.0839719725147456,"LINC00471","long intergenic non-protein coding RNA 471",TRUE
+"235771_at",0.714813484380156,0.190531465881853,1.35036592400803,-5.08853372485174,1.12002941528811,"LINC00472","long intergenic non-protein coding RNA 472",TRUE
+"220324_at",0.73957587762701,0.227841399503629,1.24029302826674,-5.21697108602564,1.70266798600485,"LINC00472","long intergenic non-protein coding RNA 472",TRUE
+"230251_at",0.909441642299191,0.62388792601951,0.497283683446562,-5.81994961546506,0.365142855789933,"LINC00473","long intergenic non-protein coding RNA 473",TRUE
+"1570345_at",0.704449222279154,0.176368691162488,-1.39659804577035,-5.03186000639104,-1.52727943270709,"LINC00474","long intergenic non-protein coding RNA 474",TRUE
+"220660_at",0.89390639630277,0.56970355305721,-0.577079317069757,-5.77877027728975,-0.367234152979651,"LINC00474","long intergenic non-protein coding RNA 474",TRUE
+"233524_at",0.765228531154075,0.265259203293709,1.1429506027707,-5.32268908196344,0.939634421879982,"LINC00475","long intergenic non-protein coding RNA 475",TRUE
+"233525_s_at",0.896088893964183,0.577079118379027,-0.566004187103328,-5.78484072235595,-0.2314192601976,"LINC00475","long intergenic non-protein coding RNA 475",TRUE
+"235776_x_at",0.940823119499826,0.735123996125324,0.342605749817415,-5.88267379586681,0.213761361001868,"LINC00475","long intergenic non-protein coding RNA 475",TRUE
+"239799_at",0.955396260969248,0.795714746660818,0.262035573752579,-5.90629566440193,0.127949313714688,"LINC00476","long intergenic non-protein coding RNA 476",TRUE
+"1553484_at",0.693988314656736,0.163371259221707,1.44170608800362,-4.9750490787428,0.692835529188641,"LINC00477","long intergenic non-protein coding RNA 477",TRUE
+"1553918_at",0.374354475700726,0.0113625627150891,2.76067069536015,-2.78424162686944,1.37646755377937,"LINC00479","long intergenic non-protein coding RNA 479",TRUE
+"243263_at",0.977874971442423,0.89302324558896,0.136033437090554,-5.93067434805733,0.0920951217491455,"LINC00482","long intergenic non-protein coding RNA 482",TRUE
+"207259_at",0.92148618812595,0.66536037183687,0.438373011332536,-5.84651510165299,0.164485546013729,"LINC00483","long intergenic non-protein coding RNA 483",TRUE
+"236008_at",0.918583761142768,0.654116235558084,0.454181340378592,-5.83970814279761,0.122553872627618,"LINC00484","long intergenic non-protein coding RNA 484",TRUE
+"1561222_at",0.977415153466377,0.891803060737516,-0.137595255133914,-5.93046638526067,-0.155125904764491,"LINC00485","long intergenic non-protein coding RNA 485",TRUE
+"1563083_s_at",0.585036027492332,0.0652302079572251,-1.93986772583159,-4.25626239585346,-1.64360510346059,"LINC00486","long intergenic non-protein coding RNA 486",TRUE
+"1563082_at",0.585036027492332,0.065357429226749,1.93887703933237,-4.25784414964811,1.16187431969747,"LINC00486","long intergenic non-protein coding RNA 486",TRUE
+"1564309_at",0.980001024522674,0.90505114791469,0.120655794615927,-5.93259538953248,0.0940569899112731,"LINC00486","long intergenic non-protein coding RNA 486",TRUE
+"231455_at",0.918482003504129,0.65385992911219,0.454543044398185,-5.83954962860227,0.38605597389433,"LINC00487","long intergenic non-protein coding RNA 487",TRUE
+"1569332_at",0.535243600695458,0.0427693279751138,2.1495048159206,-3.90956073081179,1.51640322602733,"LINC00488","long intergenic non-protein coding RNA 488",TRUE
+"1569923_s_at",0.970526265934304,0.859427182708124,-0.179176915085204,-5.92405871383102,-0.170064118320901,"LINC00491","long intergenic non-protein coding RNA 491",TRUE
+"1564282_a_at",0.985498770484702,0.92970323810741,-0.0892268802872353,-5.93580650255472,-0.0678154041802088,"LINC00491","long intergenic non-protein coding RNA 491",TRUE
+"1564281_at",0.988065316951061,0.943103149441701,-0.0721839659021547,-5.93714594479478,-0.0272485067532049,"LINC00491","long intergenic non-protein coding RNA 491",TRUE
+"226236_at",0.854184492233394,0.464649773762917,-0.744074901288289,-5.67356112602133,-0.264704150533797,"LINC00493","long intergenic non-protein coding RNA 493",TRUE
+"236854_at",0.633853683221506,0.104778593305093,1.69140660721089,-4.63475971595862,1.04423079143867,"LINC00494","long intergenic non-protein coding RNA 494",TRUE
+"1553882_at",0.911393258378799,0.629438777450817,-0.48929927788863,-5.82374183596602,-0.575383550539401,"LINC00504","long intergenic non-protein coding RNA 504",TRUE
+"1557475_at",0.819018525257656,0.373350657350865,-0.908577135229723,-5.54541180411452,-0.883056430737451,"LINC00507","long intergenic non-protein coding RNA 507",TRUE
+"1555187_at",0.835051144713132,0.413837143432044,0.832813694441605,-5.60739784275568,0.252711248456841,"LINC00508","long intergenic non-protein coding RNA 508",TRUE
+"1564122_at",0.987748774409611,0.941807391084076,0.0738309601649883,-5.93702884314307,0.0547694018287208,"LINC00514","long intergenic non-protein coding RNA 514",TRUE
+"1556414_at",0.718706241731185,0.194394035997162,1.33822951896338,-5.10314705377289,0.820174701730134,"LINC00515","long intergenic non-protein coding RNA 515",TRUE
+"244829_at",0.391240007651669,0.0131266550889045,2.69669939304905,-2.90866948404311,2.52545281881489,"LINC00518","long intergenic non-protein coding RNA 518",TRUE
+"237651_x_at",0.737123149977386,0.222884189446252,1.25407666679072,-5.20139793231177,1.23615394301073,"LINC00518","long intergenic non-protein coding RNA 518",TRUE
+"1555786_s_at",0.98693003519805,0.93976679410913,-0.0764251195501779,-5.9368390433233,-0.0216418769052833,"LINC00520","long intergenic non-protein coding RNA 520",TRUE
+"1553053_at",0.877074739399942,0.526224074858036,0.643940847187945,-5.7397112992621,0.407479282416574,"LINC00521","long intergenic non-protein coding RNA 521",TRUE
+"1570111_at",0.935344003152574,0.712481562030225,-0.373288262873895,-5.87204105316159,-0.337183719911802,"LINC00521","long intergenic non-protein coding RNA 521",TRUE
+"234816_at",0.955816406528307,0.798853682350363,0.257914061736224,-5.90733604027227,0.134905958180375,"LINC00521","long intergenic non-protein coding RNA 521",TRUE
+"1560198_at",0.778580821633075,0.298898545794974,-1.06374969669754,-5.4030754159493,-0.352529222934058,"LINC00523","long intergenic non-protein coding RNA 523",TRUE
+"1553708_at",0.166945616793658,0.0013679311627537,3.65906520011958,-0.932757346636521,1.55256877005933,"LINC00525","long intergenic non-protein coding RNA 525",TRUE
+"229829_at",0.820799255592816,0.381688542724231,0.892552622135942,-5.55893945911823,0.758950703595357,"LINC00526","long intergenic non-protein coding RNA 526",TRUE
+"1566927_at",0.673366993714442,0.139555489248331,1.53249512988271,-4.8562804438969,0.381435954424322,"LINC00527","long intergenic non-protein coding RNA 527",TRUE
+"1566926_at",0.808266620412549,0.351140480946012,0.95245804359592,-5.50723441799713,0.446824223685079,"LINC00527","long intergenic non-protein coding RNA 527",TRUE
+"1556072_at",0.942373096422033,0.741172188494436,0.334467557205411,-5.88534283757862,0.229866860783582,"LINC00528","long intergenic non-protein coding RNA 528",TRUE
+"1565424_at",0.971525376569422,0.864448798257445,-0.172708123316347,-5.92516574908351,-0.151702848124308,"LINC00529","long intergenic non-protein coding RNA 529",TRUE
+"1561423_at",0.493519901382617,0.0298955775976689,-2.32067006878145,-3.61010928335935,-1.00062058116595,"LINC00535","long intergenic non-protein coding RNA 535",TRUE
+"238244_at",0.578003664774837,0.0616431526164075,-1.96852700771562,-4.21026533701046,-1.53109964653387,"LINC00535","long intergenic non-protein coding RNA 535",TRUE
+"1561288_at",0.851733415458562,0.456112354008347,0.758555554825211,-5.66324425791824,0.670116250932976,"LINC00536","long intergenic non-protein coding RNA 536",TRUE
+"1554516_at",0.902212740485572,0.600788347929435,0.530872868025117,-5.80334086305993,0.16668016686695,"LINC00537","long intergenic non-protein coding RNA 537",TRUE
+"232034_at",0.973071267819624,0.870744933201709,-0.164608118969656,-5.92649471039577,-0.101547071329502,"LINC00537","long intergenic non-protein coding RNA 537",TRUE
+"1554517_x_at",0.986844665519238,0.938446119841947,0.0781043447309096,-5.93671269178618,0.0325158785685673,"LINC00537","long intergenic non-protein coding RNA 537",TRUE
+"1561367_a_at",0.899808883319249,0.591850970648097,0.544034278446751,-5.79654494712386,0.342276022021299,"LINC00540","long intergenic non-protein coding RNA 540",TRUE
+"232448_at",0.904776580908915,0.609274150085129,-0.518463720649288,-5.80959996989417,-0.355097839892048,"LINC00543","long intergenic non-protein coding RNA 543",TRUE
+"233804_at",0.822452640841017,0.387344645234629,-0.881812593806031,-5.5678812846396,-0.592659904114012,"LINC00544","long intergenic non-protein coding RNA 544",TRUE
+"239781_at",0.792436690618566,0.323781594906326,-1.0091828602779,-5.45544691290726,-0.501130679134576,"LINC00545","long intergenic non-protein coding RNA 545",TRUE
+"1557717_at",0.70772084164277,0.179347113630089,1.38663727019413,-5.04420428145752,1.06619860400837,"LINC00550","long intergenic non-protein coding RNA 550",TRUE
+"244119_at",0.954449231029359,0.791000710125353,0.268233986400377,-5.90470017860889,0.235160250456719,"LINC00551","long intergenic non-protein coding RNA 551",TRUE
+"1562173_a_at",0.932830928398943,0.70355513138266,-0.385483730985782,-5.86756504867409,-0.224474393177687,"LINC00555","long intergenic non-protein coding RNA 555",TRUE
+"1560988_a_at",0.692289844352812,0.161830951973579,1.44724091805412,-4.9679765526616,1.0773557139487,"LINC00556","long intergenic non-protein coding RNA 556",TRUE
+"233661_at",0.822194239143673,0.386818516936309,0.882807287869234,-5.56705734824753,0.642274571119852,"LINC00557","long intergenic non-protein coding RNA 557",TRUE
+"1556884_a_at",0.532427565606913,0.0419417562884129,2.15898905715376,-3.89333560472384,2.3201440513665,"LINC00558","long intergenic non-protein coding RNA 558",TRUE
+"1563568_at",0.170216197690753,0.00140718283230399,3.64738227292533,-0.957684250950866,1.62828160719685,"LINC00559","long intergenic non-protein coding RNA 559",TRUE
+"1561478_at",0.903383391791809,0.603499851975182,0.526898633985782,-5.80536113430231,0.424330316327109,"LINC00560","long intergenic non-protein coding RNA 560",TRUE
+"1561287_at",0.821745015752602,0.384513531805525,-0.887175512068392,-5.56342881715242,-0.722983667586807,"LINC00561","long intergenic non-protein coding RNA 561",TRUE
+"215738_at",0.54295328972902,0.0460614354796013,2.11334536618015,-3.97100681386816,0.607298694755262,"LINC00563","long intergenic non-protein coding RNA 563",TRUE
+"1562990_at",0.878788356961452,0.532122989690325,0.634701379242106,-5.74535414727379,0.644747147494802,"LINC00564","long intergenic non-protein coding RNA 564",TRUE
+"1558847_at",0.994083192910649,0.972513881615529,-0.0348468699955769,-5.93909205517911,-0.0175452743572295,"LINC00565","long intergenic non-protein coding RNA 565",TRUE
+"1569983_at",0.965682789065794,0.839507726942967,-0.204917078697472,-5.91925187914026,-0.137947166361547,"LINC00566","long intergenic non-protein coding RNA 566",TRUE
+"1559079_at",0.802255823093278,0.339987165716505,-0.975203254448178,-5.4867967728533,-0.846969538056261,"LINC00567","long intergenic non-protein coding RNA 567",TRUE
+"1563296_at",0.936143408699214,0.714809740337119,0.370116992350255,-5.87318172431641,0.132773680747447,"LINC00572","long intergenic non-protein coding RNA 572",TRUE
+"220904_at",0.943464796017993,0.747081820292588,-0.326537998198175,-5.8878823938859,-0.281022145969851,"LINC00574","long intergenic non-protein coding RNA 574",TRUE
+"236986_at",0.741260241503758,0.231871890278866,1.22925354951448,-5.22933691857055,0.725547893416603,"LINC00582","long intergenic non-protein coding RNA 582",TRUE
+"1563260_at",0.630603891142543,0.101604132779142,1.70803783852432,-4.61061303899306,1.17642151398784,"LINC00587","long intergenic non-protein coding RNA 587",TRUE
+"210464_at",0.672434875127089,0.138440028048671,-1.53704966055445,-4.85016961968944,-0.943508676038613,"LINC00588","long intergenic non-protein coding RNA 588",TRUE
+"232718_at",0.714362239193388,0.18931820877713,1.35421795679715,-5.08387244046379,0.525661094635412,"LINC00589","long intergenic non-protein coding RNA 589",TRUE
+"1558195_at",0.80110325033185,0.337607344399964,0.980122250301752,-5.48231894427054,0.533150826137049,"LINC00592","long intergenic non-protein coding RNA 592",TRUE
+"1554715_at",0.740476003158683,0.229218306962041,1.23650511292712,-5.2212248425461,0.701798398510046,"LINC00593","long intergenic non-protein coding RNA 593",TRUE
+"1554716_s_at",0.887402678698685,0.551869517715824,-0.604166706720369,-5.76344386377055,-0.424901162209679,"LINC00593","long intergenic non-protein coding RNA 593",TRUE
+"244701_at",0.899808883319249,0.592888768387742,0.542501037674882,-5.7973449651478,0.200620168841569,"LINC00595","long intergenic non-protein coding RNA 595",TRUE
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+"233432_at",0.56559911410714,0.0565785140840257,2.01161376298925,-4.14025543599946,0.937135086059355,"LINC00598","long intergenic non-protein coding RNA 598",TRUE
+"1554927_at",0.902521078772712,0.601552455073556,0.529752047890142,-5.80391211928226,0.356922540283523,"LINC00598","long intergenic non-protein coding RNA 598",TRUE
+"1555264_a_at",0.98539961718117,0.927982488039783,0.0914173008734966,-5.93561385390045,0.0725152285556971,"LINC00598","long intergenic non-protein coding RNA 598",TRUE
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+"244557_at",0.780429362666663,0.301940524563083,1.05691043744396,-5.40977540523184,0.558796816900495,"LINC00610","long intergenic non-protein coding RNA 610",TRUE
+"1555040_at",0.932411919177942,0.701688509689751,0.38804142671399,-5.86660832343684,0.17596523476295,"LINC00612","long intergenic non-protein coding RNA 612",TRUE
+"1553497_at",0.878774484192636,0.53194184414887,0.634984277283202,-5.7451825357884,0.362774530674786,"LINC00615","long intergenic non-protein coding RNA 615",TRUE
+"1561098_at",0.807528762746328,0.348849351579239,0.957089840230653,-5.50310829053334,0.60273533086735,"LINC00616","long intergenic non-protein coding RNA 616",TRUE
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+"229640_x_at",0.769847953580141,0.277878176357557,1.11242923704111,-5.35427382168734,0.54840696511444,"LINC00621","long intergenic non-protein coding RNA 621",TRUE
+"1558404_at",0.805728806042784,0.345162873253481,0.964586072312292,-5.49639165867269,0.479282435611699,"LINC00622","long intergenic non-protein coding RNA 622",TRUE
+"229429_x_at",0.551046281220434,0.0492741704414578,2.0802338742742,-4.02668916966427,1.26129650094696,"LINC00623","long intergenic non-protein coding RNA 623",TRUE
+"222001_x_at",0.675352428480841,0.141562265541541,1.52437611109813,-4.86713800792274,2.07094931127177,"LINC00623///LINC00869","long intergenic non-protein coding RNA 623///long intergenic non-protein coding RNA 869",TRUE
+"1557597_at",0.908008907845691,0.618308929311251,0.505341728357474,-5.81606166696808,0.509867074857021,"LINC00624","long intergenic non-protein coding RNA 624",TRUE
+"224020_at",0.933400538871064,0.705379934123516,-0.38298586499357,-5.8684933741644,-0.255493659981754,"LINC00626","long intergenic non-protein coding RNA 626",TRUE
+"1565556_at",0.7994347047598,0.334801875508357,0.985951726564859,-5.47698572616634,0.777913721330919,"LINC00628","long intergenic non-protein coding RNA 628",TRUE
+"1565554_at",0.974982245454858,0.878019741640677,-0.155263028519193,-5.92794885710424,-0.0835842544035721,"LINC00628","long intergenic non-protein coding RNA 628",TRUE
+"232822_x_at",0.973804347453872,0.873600904220667,-0.160937646734992,-5.92707596295952,-0.116413771241822,"LINC00629","long intergenic non-protein coding RNA 629",TRUE
+"1569674_at",0.76145107371764,0.260543697980971,-1.15462978098082,-5.31040374438035,-0.869173733566828,"LINC00630","long intergenic non-protein coding RNA 630",TRUE
+"1559510_at",0.852718195605686,0.458791242069181,0.753994457767712,-5.66651415950006,0.311091080707571,"LINC00630","long intergenic non-protein coding RNA 630",TRUE
+"1557133_at",0.812302873476553,0.359561180889064,0.935608018076613,-5.52209002199997,0.768337232612497,"LINC00632","long intergenic non-protein coding RNA 632",TRUE
+"238283_at",0.903006708266697,0.602776847012229,-0.527957495513191,-5.8048243142751,-0.267700911045469,"LINC00635","long intergenic non-protein coding RNA 635",TRUE
+"1560514_at",0.902681832009074,0.602035537342678,0.529043799559444,-5.80427249127791,0.185000340157077,"LINC00636","long intergenic non-protein coding RNA 636",TRUE
+"1553780_at",0.998870448604467,0.996391676465114,-0.00457367777024448,-5.93967329211034,-0.00219450251186437,"LINC00638","long intergenic non-protein coding RNA 638",TRUE
+"1557821_at",0.948419621702021,0.76479204257651,0.302899468480346,-5.89509490386947,0.21549646944305,"LINC00639","long intergenic non-protein coding RNA 639",TRUE
+"240902_at",0.826842911318947,0.395108635020504,0.86723507793865,-5.57985735684008,0.431600928548625,"LINC00641","long intergenic non-protein coding RNA 641",TRUE
+"1557657_a_at",0.750020866111355,0.242902159058875,1.19976726416678,-5.26189676841274,0.40747678957462,"LINC00642","long intergenic non-protein coding RNA 642",TRUE
+"1561728_a_at",0.80861715520522,0.351789913151869,-0.951148864625986,-5.50839734685406,-0.646552389735382,"LINC00642","long intergenic non-protein coding RNA 642",TRUE
+"1557656_at",0.825648186672984,0.393264778242437,-0.870680129749171,-5.57704382811134,-0.589332265805315,"LINC00642","long intergenic non-protein coding RNA 642",TRUE
+"236902_at",0.765228531154075,0.26526913500404,1.14292616644924,-5.32271467131662,0.760072206608593,"LINC00643","long intergenic non-protein coding RNA 643",TRUE
+"231186_at",0.929126743655924,0.68837681090328,-0.406359315383349,-5.85957424684255,-0.229979456632412,"LINC00643","long intergenic non-protein coding RNA 643",TRUE
+"237540_at",0.922486281852799,0.668863715985195,0.433470888526067,-5.84857784989582,0.363884636410267,"LINC00644","long intergenic non-protein coding RNA 644",TRUE
+"1559992_a_at",0.975242094553739,0.879920763903621,-0.152823374431944,-5.92831452728215,-0.169108109494124,"LINC00645","long intergenic non-protein coding RNA 645",TRUE
+"1557215_at",0.680972290639028,0.14893905716049,1.49531940749396,-4.9056180175273,1.58247666896974,"LINC00648","long intergenic non-protein coding RNA 648",TRUE
+"220747_at",0.774230543658252,0.286913230360216,-1.09119116038685,-5.37580437752276,-0.715716332560449,"LINC00652","long intergenic non-protein coding RNA 652",TRUE
+"229992_at",0.891653456393983,0.561626055298867,0.589292726918978,-5.7719439027927,0.23103561723612,"LINC00654","long intergenic non-protein coding RNA 654",TRUE
+"1554382_at",0.857287594027564,0.47236957105682,-0.731116707168903,-5.68263344728951,-0.450598753458128,"LINC00656","long intergenic non-protein coding RNA 656",TRUE
+"231458_at",0.868714861166452,0.504881062993744,0.677855583025144,-5.71832807885404,0.322552420241635,"LINC00658","long intergenic non-protein coding RNA 658",TRUE
+"1562478_at",0.913637484000037,0.638027197670087,-0.477008626369088,-5.82946205297609,-0.278502642412829,"LINC00659","long intergenic non-protein coding RNA 659",TRUE
+"237242_at",0.705559553212919,0.177562797958563,1.39258862572712,-5.03683762491283,0.497060681788238,"LINC00661","long intergenic non-protein coding RNA 661",TRUE
+"1555988_a_at",0.904832003218088,0.609545624354336,0.518068100219889,-5.80979714674037,0.307922233726549,"LINC00661","long intergenic non-protein coding RNA 661",TRUE
+"232281_at",0.727822268767891,0.208081609770143,1.29668591099109,-5.15232709164365,1.09361042099932,"LINC00662","long intergenic non-protein coding RNA 662",TRUE
+"235191_at",0.739189560382301,0.226068842910321,1.24519514033731,-5.2114494882246,0.784152360610443,"LINC00662","long intergenic non-protein coding RNA 662",TRUE
+"242663_at",0.768852835478002,0.273816843227527,1.12213965296992,-5.34430707753735,0.76274684141529,"LINC00662","long intergenic non-protein coding RNA 662",TRUE
+"1558256_at",0.830635993561085,0.404023928181445,0.850722327697902,-5.59319894166614,0.350594478533257,"LINC00662","long intergenic non-protein coding RNA 662",TRUE
+"236653_at",0.876676432191289,0.525654661854528,-0.644835698038641,-5.73916062189514,-0.455796506712331,"LINC00662","long intergenic non-protein coding RNA 662",TRUE
+"216126_at",0.741260241503758,0.231610235143821,1.2299657766094,-5.2285419972095,0.345750294587146,"LINC00663","long intergenic non-protein coding RNA 663",TRUE
+"1555363_s_at",0.783844746433788,0.30644191181978,-1.04687931902771,-5.41953207370349,-1.26911356190433,"LINC00663","long intergenic non-protein coding RNA 663",TRUE
+"1569318_at",0.897300940949134,0.583478263754963,0.556452905018748,-5.78998431521287,0.205494059484133,"LINC00663","long intergenic non-protein coding RNA 663",TRUE
+"1560390_s_at",0.963379172403332,0.833113745396879,-0.213208722216717,-5.91756680727821,-0.177197254664801,"LINC00663","long intergenic non-protein coding RNA 663",TRUE
+"231581_at",0.604219609854955,0.0785071076069429,1.84460129437937,-4.4057818178134,1.52261730382331,"LINC00664","long intergenic non-protein coding RNA 664",TRUE
+"1562348_at",0.930062315015015,0.691163455352082,0.402513171901798,-5.86107766099982,0.127151260436064,"LINC00664","long intergenic non-protein coding RNA 664",TRUE
+"231470_at",0.939976205834042,0.730419359684016,-0.348952433790729,-5.88054828071317,-0.304504241568402,"LINC00664","long intergenic non-protein coding RNA 664",TRUE
+"1557044_at",0.826972777844725,0.395222655419893,-0.867022384439404,-5.58003072097809,-0.477481517182297,"LINC00665","long intergenic non-protein coding RNA 665",TRUE
+"1557046_x_at",0.839977781712505,0.428814994845166,-0.805989583349261,-5.62813626557279,-0.498218747104087,"LINC00665","long intergenic non-protein coding RNA 665",TRUE
+"243924_at",0.920835753388243,0.663436863081567,-0.44106915985747,-5.84537089250025,-0.411799856362222,"LINC00665","long intergenic non-protein coding RNA 665",TRUE
+"242462_at",0.964685626382167,0.836770014415723,0.208465480100887,-5.91853890032896,0.108834581078793,"LINC00665","long intergenic non-protein coding RNA 665",TRUE
+"226235_at",0.708043561232082,0.179966737456648,1.38458160235974,-5.04674273755956,1.50006256709465,"LINC00667","long intergenic non-protein coding RNA 667",TRUE
+"215283_at",0.734042693548791,0.218380378441152,1.26680439688346,-5.18688674706918,1.04163300265977,"LINC00667","long intergenic non-protein coding RNA 667",TRUE
+"228160_at",0.775341201891078,0.291894611803963,-1.0796877666102,-5.38731184478632,-0.608606083425514,"LINC00667","long intergenic non-protein coding RNA 667",TRUE
+"243426_at",0.836073870069938,0.417313617374076,0.826533956933446,-5.61230987380789,0.732419265010966,"LINC00667","long intergenic non-protein coding RNA 667",TRUE
+"242683_at",0.884769004468037,0.544728171715892,0.61514138248925,-5.75704105811993,0.52193193264194,"LINC00668","long intergenic non-protein coding RNA 668",TRUE
+"1570189_at",0.928295253101366,0.685141938821018,0.410831944657963,-5.85780825219295,0.267730609626271,"LINC00671","long intergenic non-protein coding RNA 671",TRUE
+"1556737_at",0.994098505325585,0.972696247353586,-0.0346155700609076,-5.93909988020082,-0.0194920575611484,"LINC00671","long intergenic non-protein coding RNA 671",TRUE
+"238359_at",0.873301865850313,0.518311432070584,0.656423792088535,-5.73196318340558,0.433124843082462,"LINC00672","long intergenic non-protein coding RNA 672",TRUE
+"238360_s_at",0.899842372425294,0.593804389409719,0.54114939209088,-5.79804840985202,0.324054789331677,"LINC00672","long intergenic non-protein coding RNA 672",TRUE
+"230858_at",0.70573152022539,0.177963149089542,1.39124918145267,-5.03849788177343,1.05159991137279,"LINC00673","long intergenic non-protein coding RNA 673",TRUE
+"230812_at",0.245363000968222,0.00331267571679913,3.29072090491481,-1.71052735909395,1.06647020574145,"LINC00673///LINC00511","long intergenic non-protein coding RNA 673///long intergenic non-protein coding RNA 511",TRUE
+"227452_at",0.346950498371304,0.0089505387150125,2.86540263373624,-2.57779683395774,2.36649568980455,"LINC00673///LINC00511","long intergenic non-protein coding RNA 673///long intergenic non-protein coding RNA 511",TRUE
+"225054_x_at",0.642592458809121,0.113070127464004,-1.6498981606928,-4.69424415992682,-0.942015189900079,"LINC00674","long intergenic non-protein coding RNA 674",TRUE
+"225055_at",0.736116063927188,0.221414705975831,-1.25820757953801,-5.19670194147231,-0.639443651804378,"LINC00674","long intergenic non-protein coding RNA 674",TRUE
+"1566987_s_at",0.75536453281804,0.249407052410354,-1.182847732172,-5.28026963941948,-0.464085403045111,"LINC00674","long intergenic non-protein coding RNA 674",TRUE
+"227567_at",0.769258076576208,0.276137307546993,-1.11657880027913,-5.35002410970808,-0.467249460144574,"LINC00674","long intergenic non-protein coding RNA 674",TRUE
+"215658_at",0.851733415458562,0.456044382091094,-0.758671493362639,-5.6631608971467,-0.418100960034863,"LINC00675","long intergenic non-protein coding RNA 675",TRUE
+"236001_at",0.934867348047609,0.710797264690826,0.375584918098631,-5.87120897677492,0.111720165267617,"LINC00675","long intergenic non-protein coding RNA 675",TRUE
+"1569418_at",0.857148066512338,0.471937187425345,-0.731839169782311,-5.68213161700473,-0.531335592134736,"LINC00682","long intergenic non-protein coding RNA 682",TRUE
+"232463_at",0.41501369736632,0.0167910524854348,-2.58635416219066,-3.12006533075523,-1.16102820291937,"LINC00685","long intergenic non-protein coding RNA 685",TRUE
+"232836_at",0.966593471043185,0.84409058738339,-0.198983139815808,-5.92041694172375,-0.174021672952591,"LINC00687","long intergenic non-protein coding RNA 687",TRUE
+"236753_at",0.457293235105194,0.022674384277461,2.44937775844629,-3.37627421349239,1.72872083717452,"LINC00689","long intergenic non-protein coding RNA 689",TRUE
+"243261_at",0.820536502908875,0.380638645532562,0.894557652920405,-5.55725902742064,0.214977302256091,"LINC00689","long intergenic non-protein coding RNA 689",TRUE
+"1570376_at",0.839519981963042,0.427398660023046,-0.808500780049379,-5.62622180743698,-0.446667849025923,"LINC00689","long intergenic non-protein coding RNA 689",TRUE
+"237471_at",0.85069818933195,0.453656609633504,0.762750893227948,-5.66022010581656,0.418093424875009,"LINC00689","long intergenic non-protein coding RNA 689",TRUE
+"1559712_at",0.936318756756998,0.715689111587121,0.368920185554776,-5.87360970642047,0.228472344476405,"LINC00689","long intergenic non-protein coding RNA 689",TRUE
+"244325_at",0.778686132916778,0.299463305403409,1.06247621453154,-5.40432590067488,0.825731129926746,"LINC00690","long intergenic non-protein coding RNA 690",TRUE
+"1561059_a_at",0.591331966259927,0.0685701943007235,1.91440490609164,-4.29673990468895,1.50934638948142,"LINC00691","long intergenic non-protein coding RNA 691",TRUE
+"1556528_at",0.764773853888404,0.264855837647498,-1.14394362725738,-5.32164879387706,-1.16027638251555,"LINC00692","long intergenic non-protein coding RNA 692",TRUE
+"1556529_a_at",0.833355923558872,0.410802173786168,0.838323254889393,-5.6030596219128,0.657976936346492,"LINC00692","long intergenic non-protein coding RNA 692",TRUE
+"1564250_at",0.873081085324568,0.517481305209885,0.657739461004074,-5.73113823807027,0.494105403047207,"LINC00693","long intergenic non-protein coding RNA 693",TRUE
+"1557369_a_at",0.842224301155785,0.435815453649739,0.793652541413175,-5.63746034441864,0.264303193790323,"LINC00698","long intergenic non-protein coding RNA 698",TRUE
+"1564209_at",0.895213601869362,0.572931797634099,0.572222902155446,-5.78144618233496,0.274877924229926,"LINC00700","long intergenic non-protein coding RNA 700",TRUE
+"236304_at",0.895457620469779,0.574496671996879,0.569873780437798,-5.78273269589268,0.416749264342545,"LINC00702","long intergenic non-protein coding RNA 702",TRUE
+"1558660_at",0.77204612088057,0.282329656729433,1.10190390317693,-5.36499020342142,0.735309835602547,"LINC00703","long intergenic non-protein coding RNA 703",TRUE
+"1560472_at",0.896118635245982,0.57839264078443,0.564039325396366,-5.78590578345683,0.394792088447964,"LINC00705","long intergenic non-protein coding RNA 705",TRUE
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+"231421_at",0.994951215458603,0.976371513748804,-0.0299545143698677,-5.93924646163627,-0.0240114805775309,"LINC00710","long intergenic non-protein coding RNA 710",TRUE
+"1569911_at",0.61591966964196,0.0870158218326722,1.79069805562986,-4.48800406293795,0.51673057070975,"LINC00824","long intergenic non-protein coding RNA 824",TRUE
+"1555580_at",0.748659576527171,0.241635425785497,1.20310153865356,-5.25824931958642,0.821971656705176,"LINC00824","long intergenic non-protein coding RNA 824",TRUE
+"240578_at",0.76719388846109,0.269131771465445,-1.13347298976176,-5.33257771409208,-0.919862514715007,"LINC00836","long intergenic non-protein coding RNA 836",TRUE
+"215929_at",0.729273475042162,0.211477123223156,-1.28671024941166,-5.16394078331456,-0.795749293773166,"LINC00837","long intergenic non-protein coding RNA 837",TRUE
+"1561984_at",0.528412182286162,0.0411047539625397,2.16875504654278,-3.87658192582118,1.2600686721603,"LINC00838","long intergenic non-protein coding RNA 838",TRUE
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+"233566_at",0.757950630724418,0.254301780200694,1.17033247939207,-5.29371334063781,0.570744074715188,"LINC00839","long intergenic non-protein coding RNA 839",TRUE
+"1564178_at",0.918041148686074,0.651579743916158,-0.457763599715745,-5.83813279009627,-0.171684039024184,"LINC00841","long intergenic non-protein coding RNA 841",TRUE
+"240763_at",0.963737076458538,0.834321912182808,-0.211640831149588,-5.91789054449525,-0.108795265282827,"LINC00841","long intergenic non-protein coding RNA 841",TRUE
+"1563742_at",0.241160994204015,0.0032154799227202,3.30324749959384,-1.68440787416708,2.4481556725978,"LINC00842","long intergenic non-protein coding RNA 842",TRUE
+"230577_at",0.942684843065067,0.743129372929263,-0.33183900459365,-5.88619134980788,-0.352378492613619,"LINC00844","long intergenic non-protein coding RNA 844",TRUE
+"238298_at",0.942684843065067,0.743418859225026,0.331450419314888,-5.88631622543668,0.197977749282126,"LINC00845","long intergenic non-protein coding RNA 845",TRUE
+"1556180_at",0.906476756086155,0.613853004740545,-0.511802076241998,-5.81290056372684,-0.22887536415903,"LINC00847","long intergenic non-protein coding RNA 847",TRUE
+"235747_at",0.899808883319249,0.592362912016096,-0.54327777243837,-5.79693995288547,-0.288251584921921,"LINC00849///SLC25A16","long intergenic non-protein coding RNA 849///solute carrier family 25 member 16",TRUE
+"231447_at",0.725225714005638,0.20393753178858,1.30903320034861,-5.13784702215891,0.608285414204049,"LINC00851","long intergenic non-protein coding RNA 851",TRUE
+"223725_at",0.985498770484702,0.930213993933776,-0.0885768026631101,-5.9358627788902,-0.0317539181204305,"LINC00852","long intergenic non-protein coding RNA 852",TRUE
+"237224_at",0.770525343471192,0.27898161315694,-1.10980885496529,-5.35695021894338,-0.821347191191253,"LINC00853","long intergenic non-protein coding RNA 853",TRUE
+"1556754_at",0.951339758531576,0.777449100249729,-0.286113680249745,-5.89989045235172,-0.116406177770702,"LINC00856","long intergenic non-protein coding RNA 856",TRUE
+"1569322_at",0.371752195733366,0.0112256584390633,2.76602150083101,-2.7737748577324,2.62030868958377,"LINC00857","long intergenic non-protein coding RNA 857",TRUE
+"1563821_at",0.704989495199878,0.176785077262976,-1.39519750988365,-5.03360008945897,-0.733904752444144,"LINC00858","long intergenic non-protein coding RNA 858",TRUE
+"1562909_at",0.738061563377262,0.224906671309297,-1.24842512673462,-5.20780109160016,-0.857087390096026,"LINC00862","long intergenic non-protein coding RNA 862",TRUE
+"232239_at",0.834454640870101,0.412877864624353,0.834552355136554,-5.60603171102652,0.291501393936871,"LINC00865","long intergenic non-protein coding RNA 865",TRUE
+"237385_at",0.912722788750542,0.634255474770292,0.482396946377878,-5.82697177865907,0.486809600447106,"LINC00867","long intergenic non-protein coding RNA 867",TRUE
+"1556533_at",0.993952287711416,0.971573590570624,0.0360395005333007,-5.93905088074689,0.00908529326322594,"LINC00868","long intergenic non-protein coding RNA 868",TRUE
+"1563483_at",0.92777930247318,0.683282450134476,0.41340678618311,-5.85678296330043,0.181521010037482,"LINC00869","long intergenic non-protein coding RNA 869",TRUE
+"1564204_at",0.961697107105026,0.82652303727234,0.221771516801601,-5.91575679814406,0.180931188619002,"LINC00869","long intergenic non-protein coding RNA 869",TRUE
+"1557602_at",0.968980656821882,0.853552687653371,0.186754342056655,-5.92271035348472,0.105606700072443,"LINC00870","long intergenic non-protein coding RNA 870",TRUE
+"243954_at",0.986720888319514,0.937979021342827,0.0786983110109519,-5.93666734235884,0.0408594146169592,"LINC00877","long intergenic non-protein coding RNA 877",TRUE
+"1556406_at",0.935439655702811,0.712901684020571,0.372715716655194,-5.87224770208639,0.172101955203563,"LINC00879","long intergenic non-protein coding RNA 879",TRUE
+"1561402_at",0.989032420373543,0.946828026988689,-0.067450523956111,-5.9374677943194,-0.0500035384664619,"LINC00880","long intergenic non-protein coding RNA 880",TRUE
+"243687_at",0.823074246722209,0.389762520787041,-0.877252655756334,-5.5716473942323,-0.508553532594264,"LINC00881","long intergenic non-protein coding RNA 881",TRUE
+"1569885_at",0.786455312223125,0.312178067500075,1.03424662925013,-5.43170004372237,0.981762201591633,"LINC00882","long intergenic non-protein coding RNA 882",TRUE
+"1566761_a_at",0.589107392040311,0.067712272596992,1.92083948634972,-4.28654594295918,0.539547298567943,"LINC00884","long intergenic non-protein coding RNA 884",TRUE
+"1566760_at",0.929332398252332,0.689322056273472,0.405053985922343,-5.86008606303917,0.240611998571711,"LINC00884","long intergenic non-protein coding RNA 884",TRUE
+"230780_at",0.807084045192774,0.348390022768969,-0.958020911354492,-5.50227665647934,-0.593666656345828,"LINC00886","long intergenic non-protein coding RNA 886",TRUE
+"1564485_at",0.774665870681641,0.29108615580812,1.08154506414545,-5.38546125511509,1.02371264501019,"LINC00887","long intergenic non-protein coding RNA 887",TRUE
+"236798_at",0.774230543658252,0.28630266632711,1.09261099863263,-5.37437650152894,1.05343039449807,"LINC00888","long intergenic non-protein coding RNA 888",TRUE
+"228275_at",0.774230543658252,0.287550385222126,1.08971180910458,-5.37729034405943,1.71506953137668,"LINC00888","long intergenic non-protein coding RNA 888",TRUE
+"1553357_at",0.907705649734416,0.617107027092419,0.507082129790075,-5.81521392827452,0.42119536581964,"LINC00889","long intergenic non-protein coding RNA 889",TRUE
+"1559648_at",0.743869497380606,0.23464573157294,1.2217403547705,-5.23769821716712,0.565209739874258,"LINC00892","long intergenic non-protein coding RNA 892",TRUE
+"1556026_at",0.980832655742,0.910213913007185,-0.114064563247112,-5.93334842271681,-0.0687689112178456,"LINC00893","long intergenic non-protein coding RNA 893",TRUE
+"1569315_s_at",0.596440653845378,0.0729742125903432,1.88244523713711,-4.34701832092474,1.32596305340894,"LINC00894","long intergenic non-protein coding RNA 894",TRUE
+"1562839_at",0.768852835478002,0.273750069256649,1.12230018108425,-5.34414166762642,0.75299543425961,"LINC00894","long intergenic non-protein coding RNA 894",TRUE
+"232241_at",0.773234064853267,0.284348790195552,1.09716939512708,-5.3697811295912,0.691992281601992,"LINC00894","long intergenic non-protein coding RNA 894",TRUE
+"215057_at",0.867924303277286,0.501171517141688,0.683831373165313,-5.71445150019495,0.248820697035188,"LINC00894","long intergenic non-protein coding RNA 894",TRUE
+"1559136_s_at",0.909052380289506,0.622713381386011,-0.49897735240025,-5.81913749589361,-0.236247380817365,"LINC00894///LINC00893","long intergenic non-protein coding RNA 894///long intergenic non-protein coding RNA 893",TRUE
+"1561707_at",0.653206225743412,0.12260337549037,1.60522861695321,-4.75699185960098,1.15164256305593,"LINC00895","long intergenic non-protein coding RNA 895",TRUE
+"1553658_at",0.522403182336918,0.0381794557016846,-2.20436359862266,-3.81509959397039,-0.884148389803381,"LINC00896","long intergenic non-protein coding RNA 896",TRUE
+"1556304_s_at",0.630603891142543,0.101948816625203,1.70621081342987,-4.61327434867923,1.56502605953141,"LINC00899","long intergenic non-protein coding RNA 899",TRUE
+"232088_x_at",0.697713925841949,0.168643022267819,1.42307528540753,-4.99869311057942,1.74594180318506,"LINC00899","long intergenic non-protein coding RNA 899",TRUE
+"239675_at",0.959357995170594,0.815803326315322,-0.23573541900483,-5.91265299212083,-0.166240742787399,"LINC00900","long intergenic non-protein coding RNA 900",TRUE
+"239685_at",0.993007207436969,0.966722740290054,0.0421930306792368,-5.93881642291493,0.0311492016498809,"LINC00900","long intergenic non-protein coding RNA 900",TRUE
+"1556617_a_at",0.75193462989549,0.245143754510967,-1.19389884144756,-5.26829500660676,-0.954478601353484,"LINC00901","long intergenic non-protein coding RNA 901",TRUE
+"1562914_a_at",0.895690630367785,0.57588038149936,0.56779931099423,-5.78386452945918,0.359636064289784,"LINC00905","long intergenic non-protein coding RNA 905",TRUE
+"1557550_at",0.362147920783916,0.0104452347143139,2.79775978042086,-2.71150915673882,1.77009548644716,"LINC00906","long intergenic non-protein coding RNA 906",TRUE
+"1561587_at",0.588166344342661,0.0669869561265981,1.92633563785595,-4.27781994283204,1.17709965397685,"LINC00907","long intergenic non-protein coding RNA 907",TRUE
+"1570208_at",0.736094223891156,0.221340896282786,1.25841562128542,-5.19646509104344,1.07781554545776,"LINC00907","long intergenic non-protein coding RNA 907",TRUE
+"1558903_at",0.980832655742,0.910116861123152,0.114188419396544,-5.93333466182051,0.0391337207215354,"LINC00907","long intergenic non-protein coding RNA 907",TRUE
+"1558849_at",0.281385315744461,0.00473219842946819,3.13984434683308,-2.02281003416364,0.878264477443753,"LINC00908","long intergenic non-protein coding RNA 908",TRUE
+"1558850_s_at",0.778665200947143,0.299061555641318,-1.06338194808384,-5.40343666132629,-0.382251647874048,"LINC00908","long intergenic non-protein coding RNA 908",TRUE
+"241821_at",0.794426378358553,0.326328990278527,1.00376472272169,-5.4605110527614,0.829654525426151,"LINC00908","long intergenic non-protein coding RNA 908",TRUE
+"226924_at",0.768852835478002,0.273320558981338,-1.12333343059008,-5.34307649517224,-0.561245254765632,"LINC00909","long intergenic non-protein coding RNA 909",TRUE
+"1570049_at",0.691295036264984,0.160957420732992,1.45039870911629,-4.96393156974674,0.770433253302,"LINC00910","long intergenic non-protein coding RNA 910",TRUE
+"1559144_x_at",0.746149194671196,0.237594101128953,-1.21382777631437,-5.24645604060646,-0.919968388691825,"LINC00910","long intergenic non-protein coding RNA 910",TRUE
+"241312_at",0.517523674854691,0.0366065291227142,2.22454744704854,-3.7799781288752,1.47559912695152,"LINC00911","long intergenic non-protein coding RNA 911",TRUE
+"234925_at",0.7479320362828,0.239830717148789,1.20787465040245,-5.25301259391653,0.857298199831136,"LINC00917","long intergenic non-protein coding RNA 917",TRUE
+"231627_at",0.807528762746328,0.348821580852456,-0.957146108544646,-5.50305805260035,-0.741888689483606,"LINC00919","long intergenic non-protein coding RNA 919",TRUE
+"229363_at",0.904381089098038,0.607847315354677,0.520544432184178,-5.80856053143314,0.47942701188998,"LINC00920","long intergenic non-protein coding RNA 920",TRUE
+"232089_at",0.930083070178974,0.69141620893213,-0.402164626147056,-5.86121320807747,-0.242450659892691,"LINC00921///TIGD7///ZNF263","long intergenic non-protein coding RNA 921///tigger transposable element derived 7///zinc finger protein 263",TRUE
+"203707_at",0.309168889494955,0.00649548626372955,-3.00433056727438,-2.2991837337004,-0.804972235928266,"LINC00921///ZNF263","long intergenic non-protein coding RNA 921///zinc finger protein 263",TRUE
+"243547_at",0.9181984176728,0.652825948041894,-0.456002842179503,-5.83890862572598,-0.397676402216752,"LINC00921///ZNF263","long intergenic non-protein coding RNA 921///zinc finger protein 263",TRUE
+"231518_at",0.787929163003677,0.31384366008948,1.03060920541152,-5.43517897549298,0.458436461401186,"LINC00922","long intergenic non-protein coding RNA 922",TRUE
+"234017_at",0.844974084282113,0.442022469954245,0.782815597878658,-5.64553900555206,0.4779845937743,"LINC00923","long intergenic non-protein coding RNA 923",TRUE
+"1558881_at",0.756388854702832,0.251677002735808,1.17702118052429,-5.28654398245337,0.583126840406511,"LINC00924","long intergenic non-protein coding RNA 924",TRUE
+"230245_s_at",0.632216562924782,0.103382520616036,-1.69866725387998,-4.62423992163983,-1.45404023955786,"LINC00926","long intergenic non-protein coding RNA 926",TRUE
+"230648_at",0.934867348047609,0.710867426490712,-0.375489206668927,-5.87124375349131,-0.138947786866421,"LINC00926","long intergenic non-protein coding RNA 926",TRUE
+"1566526_at",0.699684100574767,0.171151859542886,1.41437259813722,-5.00965113023761,0.687934391552662,"LINC00927","long intergenic non-protein coding RNA 927",TRUE
+"1559579_at",0.85629081478032,0.470208196386037,-0.7347320179499,-5.68011749943316,-0.405160009019208,"LINC00927","long intergenic non-protein coding RNA 927",TRUE
+"1556452_a_at",0.825433910888158,0.392894659732151,0.871372916131841,-5.57647678670532,0.532766085014981,"LINC00928","long intergenic non-protein coding RNA 928",TRUE
+"1562972_at",0.770587776490794,0.279018312047339,1.10972183401908,-5.35703900405925,0.479184251063949,"LINC00929","long intergenic non-protein coding RNA 929",TRUE
+"1556768_at",0.908709061737317,0.620632350242531,-0.501981796392387,-5.81769022392767,-0.240993901830152,"LINC00930","long intergenic non-protein coding RNA 930",TRUE
+"232131_at",0.796174477255647,0.328375338048255,0.999433522188707,-5.46454148834104,0.479345368004658,"LINC00933","long intergenic non-protein coding RNA 933",TRUE
+"1564060_at",0.906393700028829,0.613148191847577,0.512825954448471,-5.81239597672132,0.336765316330844,"LINC00934","long intergenic non-protein coding RNA 934",TRUE
+"1560619_at",0.954506242294505,0.791558810135351,-0.267499593733759,-5.90489114756163,-0.108937784671888,"LINC00935","long intergenic non-protein coding RNA 935",TRUE
+"238893_at",0.94895689004559,0.768898027346534,0.297444608487994,-5.89668303530036,0.110441649297885,"LINC00936","long intergenic non-protein coding RNA 936",TRUE
+"1560119_at",0.776976656039023,0.295801746688026,-1.0707634072557,-5.39616433071048,-0.46541655663233,"LINC00937","long intergenic non-protein coding RNA 937",TRUE
+"240002_at",0.872668627020452,0.516544223206364,-0.659226047089092,-5.7302042188562,-0.446144178149508,"LINC00937","long intergenic non-protein coding RNA 937",TRUE
+"242523_at",0.171589157517339,0.00149071513160925,-3.62355136655402,-1.00848757533376,-2.16773985543411,"LINC00938","long intergenic non-protein coding RNA 938",TRUE
+"226413_at",0.406164654174876,0.0153752239764221,-2.62602022727989,-3.04456361566024,-1.43270129784527,"LINC00938","long intergenic non-protein coding RNA 938",TRUE
+"238916_at",0.71278153948281,0.186828939045782,-1.36218256695408,-5.07419941767878,-0.887900795313628,"LINC00938","long intergenic non-protein coding RNA 938",TRUE
+"228833_s_at",0.816800680706682,0.36849808671919,0.918012378413222,-5.53734278986571,0.379216974428498,"LINC00938","long intergenic non-protein coding RNA 938",TRUE
+"216209_at",0.992583835836326,0.965395126067967,-0.0438774521052345,-5.93874581531152,-0.0275812297331566,"LINC00939","long intergenic non-protein coding RNA 939",TRUE
+"1558308_at",0.790309297261437,0.31996866217063,1.01734847654415,-5.44776817133673,0.361910733939675,"LINC00942","long intergenic non-protein coding RNA 942",TRUE
+"1569378_at",0.985709215004606,0.930927815832966,0.0876683329216084,-5.93594073503081,0.0272796491518466,"LINC00942","long intergenic non-protein coding RNA 942",TRUE
+"231440_at",0.901926599164492,0.600226247966113,0.531697816197463,-5.80291965533505,0.144777873009427,"LINC00943","long intergenic non-protein coding RNA 943",TRUE
+"1560819_a_at",0.238811487311851,0.00316189212338694,3.31031231338978,-1.66966480913403,2.29162239545651,"LINC00944","long intergenic non-protein coding RNA 944",TRUE
+"243905_at",0.301989070415646,0.00579951575558169,3.05300459782942,-2.2004048764374,1.50717770290939,"LINC00944","long intergenic non-protein coding RNA 944",TRUE
+"1560573_at",0.384220082340749,0.0124812247350388,2.71910490420602,-2.86524004130875,1.66099902563376,"LINC00944","long intergenic non-protein coding RNA 944",TRUE
+"1560818_at",0.495138127083296,0.0301465274131195,2.31673493806727,-3.617145980662,0.640986762454709,"LINC00944","long intergenic non-protein coding RNA 944",TRUE
+"214344_at",0.979415860312329,0.900988995778946,0.125845724850384,-5.93197273327634,0.116207233502135,"LINC00950","long intergenic non-protein coding RNA 950",TRUE
+"1562219_at",0.971216837324271,0.863102028928875,0.174442265478711,-5.9248729583475,0.120689495570381,"LINC00951","long intergenic non-protein coding RNA 951",TRUE
+"232664_at",0.626839388794963,0.0973273877016113,1.73115769336997,-4.57675206497111,1.24571685135255,"LINC00954","long intergenic non-protein coding RNA 954",TRUE
+"1553912_at",0.868714861166452,0.50489446377248,0.677834040404483,-5.71834199498855,0.468926771647928,"LINC00955","long intergenic non-protein coding RNA 955",TRUE
+"1558123_at",0.581852599439475,0.0640461810797948,-1.94917047027257,-4.24138238356053,-1.25952379660926,"LINC00957","long intergenic non-protein coding RNA 957",TRUE
+"1564208_x_at",0.620223198657182,0.0901218182610838,-1.77215278666528,-4.51588300204874,-1.50041948579558,"LINC00957","long intergenic non-protein coding RNA 957",TRUE
+"1569089_a_at",0.64513208805899,0.115630596862575,-1.63759931729555,-4.71165258921494,-0.924465546006988,"LINC00957","long intergenic non-protein coding RNA 957",TRUE
+"1569090_x_at",0.83516820266233,0.414139557578072,-0.832266107680919,-5.60782755083958,-0.386063980119642,"LINC00957","long intergenic non-protein coding RNA 957",TRUE
+"1564207_at",0.955743694751825,0.79813994254547,-0.258850818912217,-5.90710101760254,-0.0911686243315728,"LINC00957","long intergenic non-protein coding RNA 957",TRUE
+"231924_at",0.718706241731185,0.194402366286527,-1.33820355016033,-5.1031782039086,-0.929706771226289,"LINC00958","long intergenic non-protein coding RNA 958",TRUE
+"229323_at",0.724067243569133,0.201441003053134,-1.31656605032001,-5.12895599246639,-0.81450868836741,"LINC00959","long intergenic non-protein coding RNA 959",TRUE
+"1559826_a_at",0.47652109797903,0.0263723871134186,2.37938355654437,-3.504312501228,0.835233141026176,"LINC00960","long intergenic non-protein coding RNA 960",TRUE
+"1564175_at",0.554454260421586,0.0508308165075338,2.0648817614511,-4.05231335632273,2.1745816589173,"LINC00960","long intergenic non-protein coding RNA 960",TRUE
+"1559827_at",0.761261833217751,0.260327823245224,1.15516817497892,-5.30983476044888,1.9462744861872,"LINC00960","long intergenic non-protein coding RNA 960",TRUE
+"1557371_a_at",0.961561244483099,0.825870950379657,-0.222619634518808,-5.91557366185468,-0.0843413519132152,"LINC00961","long intergenic non-protein coding RNA 961",TRUE
+"217625_x_at",0.564004192185035,0.0559010653680264,-2.01763450818533,-4.13039180908115,-1.22383489106611,"LINC00963","long intergenic non-protein coding RNA 963",TRUE
+"215185_at",0.852482434679576,0.458435874813734,-0.754598588287964,-5.66608212374964,-0.727321162361894,"LINC00963","long intergenic non-protein coding RNA 963",TRUE
+"1562703_at",0.68747436517451,0.156317902292629,-1.46740643307953,-4.94202235421739,-1.19588729579071,"LINC00964","long intergenic non-protein coding RNA 964",TRUE
+"236950_s_at",0.979551619255899,0.901312900988125,0.125431765628732,-5.93202335839919,0.119912586805752,"LINC00964","long intergenic non-protein coding RNA 964",TRUE
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+"230978_at",0.825648186672984,0.393239249105868,-0.870727901526596,-5.57700474065649,-0.538237095597462,"LINC00967","long intergenic non-protein coding RNA 967",TRUE
+"243813_at",0.821962235882611,0.38522860424896,-0.885818538451726,-5.56455778510254,-0.888889177262887,"LINC00968","long intergenic non-protein coding RNA 968",TRUE
+"229820_at",0.668299615227379,0.134466649604324,1.55352299952771,-4.82794749622915,0.851188266853307,"LINC00969","long intergenic non-protein coding RNA 969",TRUE
+"1557293_at",0.751464513744428,0.244545801953174,1.19546030998512,-5.26659522973069,0.59119234842964,"LINC00969","long intergenic non-protein coding RNA 969",TRUE
+"1561555_at",0.700061364939874,0.171623869583492,-1.41274671425454,-5.01169224320314,-0.932995265678498,"LINC00970","long intergenic non-protein coding RNA 970",TRUE
+"242005_at",0.593339168375633,0.0703491404304294,1.90128458752296,-4.31745205330046,2.74171067765682,"LINC00973","long intergenic non-protein coding RNA 973",TRUE
+"242269_at",0.837368340567858,0.42087882750417,0.820128068827252,-5.61728471629856,0.694582331409599,"LINC00982","long intergenic non-protein coding RNA 982",TRUE
+"231275_at",0.839519981963042,0.426802243822982,0.809559790509195,-5.62541277494017,0.334356999076251,"LINC00982","long intergenic non-protein coding RNA 982",TRUE
+"237108_x_at",0.868397087637799,0.504148427888535,0.67903383216716,-5.7175663074144,0.336977220876061,"LINC00982","long intergenic non-protein coding RNA 982",TRUE
+"236360_at",0.918041148686074,0.651738251119088,0.457539563971942,-5.83823166877913,0.274698633821303,"LINC00982","long intergenic non-protein coding RNA 982",TRUE
+"239319_at",0.695739345331756,0.165133608748733,-1.43542471473729,-4.98304875926626,-2.63316721725794,"LINC00992","long intergenic non-protein coding RNA 992",TRUE
+"237339_at",0.79716381564379,0.330369179673939,-0.995231412037812,-5.46843667643742,-1.15978477177322,"LINC00993","long intergenic non-protein coding RNA 993",TRUE
+"1560762_at",0.753862100951903,0.247126203128756,1.18874229278457,-5.27389455662698,1.0084771884363,"LINC00996","long intergenic non-protein coding RNA 996",TRUE
+"1560371_at",0.869971289491322,0.508082463656208,-0.67271823294274,-5.72163472893489,-0.63795627645257,"LINC00997","long intergenic non-protein coding RNA 997",TRUE
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+"232255_at",0.994007735409395,0.971791412543912,0.0357632184601729,-5.93906054240961,0.0246850585942395,"LINC00997","long intergenic non-protein coding RNA 997",TRUE
+"224723_x_at",0.801086839730802,0.337382663544412,0.980587884600845,-5.48189400744401,0.384794460621189,"LINC00998","long intergenic non-protein coding RNA 998",TRUE
+"227129_x_at",0.606900628956089,0.0805155794983097,1.83143682616043,-4.42602419562927,0.943563555945351,"LINC01000","long intergenic non-protein coding RNA 1000",TRUE
+"238678_at",0.677509122383198,0.145080393649497,1.51036765760628,-4.88576341899618,0.905326657343497,"LINC01000","long intergenic non-protein coding RNA 1000",TRUE
+"235174_s_at",0.0714488726114362,0.000210651014842573,-4.42480287802787,0.716852593864127,-2.14657121922408,"LINC01003","long intergenic non-protein coding RNA 1003",TRUE
+"235319_at",0.640067422642767,0.110584381764799,1.66206449292971,-4.6769253882357,1.22184058446596,"LINC01004","long intergenic non-protein coding RNA 1004",TRUE
+"239323_at",0.918041148686074,0.651543602354998,0.457814685907624,-5.83811023644829,0.334425197777343,"LINC01004","long intergenic non-protein coding RNA 1004",TRUE
+"235217_at",0.928167838756364,0.684232872986778,0.412090377758487,-5.85730793779851,0.191031724201689,"LINC01004","long intergenic non-protein coding RNA 1004",TRUE
+"236340_at",0.962555471240652,0.829592754858993,-0.21778120131353,-5.91660909979978,-0.183439023437863,"LINC01006///C7orf13","long intergenic non-protein coding RNA 1006///chromosome 7 open reading frame 13",TRUE
+"233135_at",0.749197955891564,0.242317394907727,1.20130484238064,-5.2602158647285,0.376879942362143,"LINC01007","long intergenic non-protein coding RNA 1007",TRUE
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+"234267_at",0.976422537443518,0.887772365769504,0.142756997614411,-5.92976222038241,0.0994558881637504,"LINC01016","long intergenic non-protein coding RNA 1016",TRUE
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+"1557877_s_at",0.73759219552868,0.224240663036739,1.25028188905662,-5.20570013038725,0.865055929101656,"LINC01020","long intergenic non-protein coding RNA 1020",TRUE
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+"231046_at",0.680160698079016,0.147419773428956,-1.50120594857795,-4.89787031253377,-1.50375734369327,"LINC01023","long intergenic non-protein coding RNA 1023",TRUE
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+"1561298_at",0.556146391774982,0.0516018407951437,2.05743292011637,-4.06470166821072,1.20319852979486,"LINC01069","long intergenic non-protein coding RNA 1069",TRUE
+"231580_at",0.588653540532996,0.0674504669221127,-1.92281734668342,-4.28340776601293,-1.34429223347588,"LINC01082","long intergenic non-protein coding RNA 1082",TRUE
+"240167_at",0.785175995766517,0.31057919296082,1.03775123074553,-5.42833769851677,1.02389402208292,"LINC01085","long intergenic non-protein coding RNA 1085",TRUE
+"1557843_at",0.8920930097751,0.562641467865349,0.587752451594161,-5.77281242174297,0.531127936933562,"LINC01087","long intergenic non-protein coding RNA 1087",TRUE
+"230781_at",0.673322568613087,0.13900358220319,1.53474485808687,-4.85326377678587,1.2695845533072,"LINC01088","long intergenic non-protein coding RNA 1088",TRUE
+"1560891_a_at",0.80110325033185,0.33779086651758,0.979742072302096,-5.48266575751691,0.411501148386621,"LINC01088","long intergenic non-protein coding RNA 1088",TRUE
+"1560890_at",0.958723944343516,0.812821510556169,-0.23962805805315,-5.91175416948598,-0.244017253193414,"LINC01088","long intergenic non-protein coding RNA 1088",TRUE
+"241886_x_at",0.76912869907427,0.275030255434281,1.1192275134045,-5.34730414205722,0.507466572407071,"LINC01089","long intergenic non-protein coding RNA 1089",TRUE
+"1556042_s_at",0.8920930097751,0.564226532923687,-0.585350935952914,-5.77416218399565,-0.231318996147587,"LINC01089","long intergenic non-protein coding RNA 1089",TRUE
+"226369_at",0.913140067375992,0.63531245952256,0.480885472996013,-5.82767308411524,0.229726177062622,"LINC01089","long intergenic non-protein coding RNA 1089",TRUE
+"1561096_at",0.829717647902857,0.401147806212421,-0.856023617415972,-5.58894176079736,-0.556256851129729,"LINC01091","long intergenic non-protein coding RNA 1091",TRUE
+"1563462_at",0.896229101808264,0.579892153884588,-0.561798984186658,-5.78711578670293,-0.370809087649914,"LINC01091","long intergenic non-protein coding RNA 1091",TRUE
+"1559573_at",0.837201352670384,0.419725051803349,0.822197400781406,-5.61568162724505,0.333674931656866,"LINC01093","long intergenic non-protein coding RNA 1093",TRUE
+"229635_at",0.886023097762234,0.548650485081536,-0.609104312588931,-5.76057694386692,-0.399081657353028,"LINC01094","long intergenic non-protein coding RNA 1094",TRUE
+"240685_at",0.653793326711711,0.123081750559555,-1.60306474301132,-4.75999765464699,-0.725075573622961,"LINC01095","long intergenic non-protein coding RNA 1095",TRUE
+"236112_at",0.813021318305036,0.362227110633537,0.930328821349221,-5.52669425900331,0.451920879410572,"LINC01096","long intergenic non-protein coding RNA 1096",TRUE
+"1562683_a_at",0.75638370471158,0.251643705326084,1.17710636510613,-5.28645244608215,1.00868533069625,"LINC01097","long intergenic non-protein coding RNA 1097",TRUE
+"1561566_at",0.993615552413264,0.969848489887403,-0.0382276953122919,-5.93897173285146,-0.0349677682430043,"LINC01098","long intergenic non-protein coding RNA 1098",TRUE
+"1553385_at",0.941484650780559,0.738258279522906,0.338385480561938,-5.88406581730858,0.24472022422097,"LINC01101","long intergenic non-protein coding RNA 1101",TRUE
+"230495_at",0.956762870061999,0.804246233726721,0.250844088548148,-5.90908251166709,0.206239291668925,"LINC01102","long intergenic non-protein coding RNA 1102",TRUE
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+"236739_at",0.673356287352323,0.139164342576624,-1.53408879623281,-4.85414385482103,-1.76665211545683,"LINC01105","long intergenic non-protein coding RNA 1105",TRUE
+"1553797_a_at",0.708222957155366,0.180086278727192,-1.38418565853589,-5.04723131305106,-1.89669309241165,"LINC01105","long intergenic non-protein coding RNA 1105",TRUE
+"1553796_at",0.891653456393983,0.561672367474443,-0.589222444870159,-5.77198358077261,-0.438614759516981,"LINC01105","long intergenic non-protein coding RNA 1105",TRUE
+"1562214_at",0.913697616562839,0.638230521748256,0.476718563626563,-5.82959533271627,0.158955881653361,"LINC01107","long intergenic non-protein coding RNA 1107",TRUE
+"1570155_at",0.582980484640151,0.0644983804588619,1.94559984194859,-4.24709947774922,0.643772389597683,"LINC01111","long intergenic non-protein coding RNA 1111",TRUE
+"239879_at",0.9317634478235,0.698767199837347,0.392049588009264,-5.86509649927195,0.275389313647591,"LINC01114","long intergenic non-protein coding RNA 1114",TRUE
+"1562844_at",0.748924337581408,0.242107684805695,1.20185693332908,-5.25961185415897,0.76744285685914,"LINC01115","long intergenic non-protein coding RNA 1115",TRUE
+"228564_at",0.819018525257656,0.373535718158792,-0.908218919903409,-5.54571663402484,-1.12377729283494,"LINC01116","long intergenic non-protein coding RNA 1116",TRUE
+"237840_at",0.998870448604467,0.995345855634721,0.00589930694811381,-5.93966653007872,0.00256574876133353,"LINC01118","long intergenic non-protein coding RNA 1118",TRUE
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+"1560912_at",0.848339436378604,0.448196304695608,0.772128549386019,-5.65340337228038,0.43676189323251,"LINC01120","long intergenic non-protein coding RNA 1120",TRUE
+"1562601_at",0.488346123638981,0.0290122617257241,2.33476692761627,-3.58484530457826,1.2215934243889,"LINC01121","long intergenic non-protein coding RNA 1121",TRUE
+"1562326_at",0.117874145553551,0.000648175173229539,3.96594459467312,-0.274117534051186,2.08100899837093,"LINC01122","long intergenic non-protein coding RNA 1122",TRUE
+"1557472_a_at",0.870433264908839,0.50896103758341,0.671311548047224,-5.72253594126866,0.560119509390359,"LINC01122","long intergenic non-protein coding RNA 1122",TRUE
+"242222_at",0.577403980266925,0.061509089053088,1.9696264223828,-4.2084916714579,2.30164225153919,"LINC01123///LINC01106","long intergenic non-protein coding RNA 1123///long intergenic non-protein coding RNA 1106",TRUE
+"235083_at",0.729083413548563,0.210825702446843,1.28861440159553,-5.16172985214018,0.830189100736485,"LINC01123///LINC01106","long intergenic non-protein coding RNA 1123///long intergenic non-protein coding RNA 1106",TRUE
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+"231189_at",0.679582597949812,0.146871641902056,1.50334187539901,-4.89505302950368,0.432054008183318,"LINC01126","long intergenic non-protein coding RNA 1126",TRUE
+"1555124_at",0.933400538871064,0.705315479692219,0.383074050554292,-5.8684607015466,0.115564710526781,"LINC01126","long intergenic non-protein coding RNA 1126",TRUE
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+"236624_at",0.886148073306164,0.548897636678877,0.608724672049289,-5.76079817346598,0.333346792258397,"LINC01128","long intergenic non-protein coding RNA 1128",TRUE
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+"1569779_at",0.943294768503521,0.745100447857775,-0.329194204275705,-5.8870384211069,-0.157455362650696,"LINC01149","long intergenic non-protein coding RNA 1149",TRUE
+"1560690_at",0.981944022360435,0.913583291728882,0.109765731963651,-5.93381679621772,0.0776228203673108,"LINC01153","long intergenic non-protein coding RNA 1153",TRUE
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+"1564490_at",0.635964808926697,0.107244545739445,-1.6787798512148,-4.65297332564285,-0.722217627617095,"LINC01165","long intergenic non-protein coding RNA 1165",TRUE
+"1563132_at",0.730101539866086,0.212685509817819,1.28319000874703,-5.16802084447672,0.692698108177227,"LINC01169","long intergenic non-protein coding RNA 1169",TRUE
+"1561400_at",0.827446445976113,0.396235991742965,-0.865133847120103,-5.58156831270058,-0.455390617251564,"LINC01180","long intergenic non-protein coding RNA 1180",TRUE
+"1562433_at",0.976371465776674,0.886875902425121,-0.143905551278414,-5.92960201479839,-0.0435012700452786,"LINC01181","long intergenic non-protein coding RNA 1181",TRUE
+"1559929_at",0.702621412021935,0.174034710728135,1.40449766214794,-5.02201820977638,0.611662536147891,"LINC01186","long intergenic non-protein coding RNA 1186",TRUE
+"240807_at",0.708894565317004,0.181461128270631,1.37964682136216,-5.05282373683951,0.383780506604904,"LINC01187","long intergenic non-protein coding RNA 1187",TRUE
+"239420_at",0.812302873476553,0.35756643028397,0.939575325498664,-5.51861419640094,0.530133963336652,"LINC01187","long intergenic non-protein coding RNA 1187",TRUE
+"230797_s_at",0.771011793494937,0.279703564850943,1.10809847819084,-5.35869413756434,0.569116445488163,"LINC01191","long intergenic non-protein coding RNA 1191",TRUE
+"230796_at",0.92710559339757,0.681539188210855,0.415823272068662,-5.85581499941393,0.158907708455413,"LINC01191","long intergenic non-protein coding RNA 1191",TRUE
+"243795_s_at",0.98539961718117,0.927923437396779,0.0914924771780583,-5.93560715924697,0.0709288604333906,"LINC01191","long intergenic non-protein coding RNA 1191",TRUE
+"240371_at",0.751464513744428,0.244457952954732,1.19568995643317,-5.26634507910035,0.544165284228436,"LINC01192","long intergenic non-protein coding RNA 1192",TRUE
+"1561492_at",0.978951900396372,0.897612257889843,-0.130162638751568,-5.93143487254767,-0.0747674207338234,"LINC01192","long intergenic non-protein coding RNA 1192",TRUE
+"231132_at",0.931582451098271,0.698275243098699,-0.392725215384163,-5.86484015413828,-0.346443586103669,"LINC01193","long intergenic non-protein coding RNA 1193",TRUE
+"1562901_at",0.779854829728531,0.301120847368695,1.05874846388343,-5.40797861481394,0.793286313288731,"LINC01197","long intergenic non-protein coding RNA 1197",TRUE
+"1553614_a_at",0.672434875127089,0.138364334972151,-1.53735981528298,-4.84975296128942,-1.48482655897214,"LINC01198","long intergenic non-protein coding RNA 1198",TRUE
+"241953_at",0.982884736081404,0.916832511807758,0.105622212263388,-5.9342512396626,0.049332684850194,"LINC01198///KRTAP21-1","long intergenic non-protein coding RNA 1198///keratin associated protein 21-1",TRUE
+"1561352_at",0.641547541078628,0.111999474706822,1.65511048581332,-4.68683630530852,0.993324211139441,"LINC01204","long intergenic non-protein coding RNA 1204",TRUE
+"231482_at",0.775716503475758,0.293006277498522,1.0771399158816,-5.3898458725792,0.482119431159797,"LINC01206","long intergenic non-protein coding RNA 1206",TRUE
+"1561983_at",0.943988850936011,0.749300785100362,0.323566119290197,-5.8888186452546,0.264243139480833,"LINC01206","long intergenic non-protein coding RNA 1206",TRUE
+"238103_at",0.949740807420078,0.772507968680123,-0.292656354085653,-5.89805350598778,-0.325509211627729,"LINC01207","long intergenic non-protein coding RNA 1207",TRUE
+"237274_at",0.755868740464627,0.25022240898677,-1.18075032233849,-5.2825313591866,-0.532640101296771,"LINC01208","long intergenic non-protein coding RNA 1208",TRUE
+"1561091_at",0.94895689004559,0.768351078173835,-0.298170703023224,-5.89647329047278,-0.148044585801965,"LINC01209","long intergenic non-protein coding RNA 1209",TRUE
+"1556508_s_at",0.55937703282623,0.0536093680310113,2.03849496810675,-4.09606559051883,1.40814763451376,"LINC01210","long intergenic non-protein coding RNA 1210",TRUE
+"1556507_at",0.812302873476553,0.360636892317626,0.933474696525829,-5.52395347541599,0.256125682689154,"LINC01210","long intergenic non-protein coding RNA 1210",TRUE
+"237514_at",0.94895689004559,0.768497658980669,0.297976095738972,-5.8965295558515,0.23264923339879,"LINC01210","long intergenic non-protein coding RNA 1210",TRUE
+"241247_at",0.937941197043043,0.72556420537605,0.355517528371967,-5.87830905322758,0.348459954412755,"LINC01213","long intergenic non-protein coding RNA 1213",TRUE
+"239736_at",0.924029559540466,0.673181771487591,0.427443567470957,-5.85108283928882,0.200484612694074,"LINC01214","long intergenic non-protein coding RNA 1214",TRUE
+"236198_at",0.591331966259927,0.0689049100510653,1.91191363283135,-4.30068032335031,0.665152166894368,"LINC01215","long intergenic non-protein coding RNA 1215",TRUE
+"1563373_at",0.841550580403629,0.432727790517555,0.799078756951073,-5.63337597854242,0.779888176437186,"LINC01220","long intergenic non-protein coding RNA 1220",TRUE
+"1561411_at",0.980009054680439,0.905924417249924,-0.11954052704415,-5.93272577489705,-0.0838247229385338,"LINC01222","long intergenic non-protein coding RNA 1222",TRUE
+"233142_at",0.483342512055348,0.0276820905044365,2.35675821550908,-3.5452588858906,1.9812733522703,"LINC01224","long intergenic non-protein coding RNA 1224",TRUE
+"1566647_s_at",0.670164229230396,0.13606630459367,1.54684328281786,-4.83698084523639,0.800735355461097,"LINC01225","long intergenic non-protein coding RNA 1225",TRUE
+"1566646_at",0.91994485246627,0.659170123808824,0.447061685671616,-5.84280309170948,0.183813353020941,"LINC01225","long intergenic non-protein coding RNA 1225",TRUE
+"1563802_at",0.91876780831279,0.654795458741209,-0.453223106406036,-5.84012748400607,-0.213192110625181,"LINC01226","long intergenic non-protein coding RNA 1226",TRUE
+"240938_at",0.726636642789909,0.205697775416603,1.30376497096786,-5.14403946727167,0.513784600413707,"LINC01227","long intergenic non-protein coding RNA 1227",TRUE
+"1562861_at",0.977895510454815,0.893304190214217,0.135673881460556,-5.93072188885885,0.039858885824783,"LINC01231","long intergenic non-protein coding RNA 1231",TRUE
+"236768_at",0.923845143651139,0.672755270132055,0.428038176217597,-5.85083724842386,0.193838906891533,"LINC01233","long intergenic non-protein coding RNA 1233",TRUE
+"1564220_a_at",0.714919799735972,0.190710658969349,1.34979863208286,-5.0892192574457,1.529124132672,"LINC01234","long intergenic non-protein coding RNA 1234",TRUE
+"1554946_at",0.879761308185056,0.534559849154352,0.63090074576267,-5.74765255239343,0.440373945988532,"LINC01234","long intergenic non-protein coding RNA 1234",TRUE
+"1560836_at",0.886782011834068,0.549863179630708,0.607242400059795,-5.76166067007754,0.589422979569663,"LINC01241","long intergenic non-protein coding RNA 1241",TRUE
+"1561414_at",0.660054711393139,0.127907163699808,1.58162064296727,-4.78961450111325,1.61894050115679,"LINC01242","long intergenic non-protein coding RNA 1242",TRUE
+"1563174_at",0.622434989367596,0.0924184270702523,1.75879054150258,-4.53583848248461,0.87801552403157,"LINC01243","long intergenic non-protein coding RNA 1243",TRUE
+"1557826_at",0.597879550155311,0.0751824369916155,-1.8670509328646,-4.37102422931601,-0.935250669147102,"LINC01252","long intergenic non-protein coding RNA 1252",TRUE
+"1561083_at",0.756207119282867,0.251128535250462,-1.17842539393307,-5.28503432517827,-0.582380945153653,"LINC01254","long intergenic non-protein coding RNA 1254",TRUE
+"241308_at",0.994536266629158,0.974795750123564,-0.0319528438613123,-5.93918620920878,-0.0284220631018961,"LINC01255","long intergenic non-protein coding RNA 1255",TRUE
+"220449_at",0.596689559015396,0.0730443253739775,1.88195023997753,-4.34779237962788,1.58151333501447,"LINC01260","long intergenic non-protein coding RNA 1260",TRUE
+"1556117_at",0.784708646973769,0.308667138988679,1.04195904779348,-5.42428715070404,0.87830542372414,"LINC01260","long intergenic non-protein coding RNA 1260",TRUE
+"234171_at",0.584247456664678,0.0647915996720016,1.94329632234509,-4.25078393510042,1.22167543261527,"LINC01267","long intergenic non-protein coding RNA 1267",TRUE
+"1557359_at",0.83560275910851,0.415027499338833,0.830659754854641,-5.60908658001416,0.674040760631768,"LINC01268","long intergenic non-protein coding RNA 1268",TRUE
+"1556896_at",0.960699983781935,0.821615237108136,-0.228158836895803,-5.91436045946566,-0.128566902616738,"LINC01270","long intergenic non-protein coding RNA 1270",TRUE
+"1562549_at",0.860714927752408,0.480436398183831,0.717708511683676,-5.6918614197633,0.378168783207101,"LINC01271","long intergenic non-protein coding RNA 1271",TRUE
+"237255_at",0.712706052684454,0.18673094110114,1.36249782750961,-5.07381555958736,1.08937323255941,"LINC01272","long intergenic non-protein coding RNA 1272",TRUE
+"212957_s_at",0.42537276038623,0.018041873458357,-2.55383893955656,-3.18152993950053,-1.98504363039142,"LINC01278","long intergenic non-protein coding RNA 1278",TRUE
+"216838_at",0.995618448898906,0.97906466607535,-0.0265394355991301,-5.93934042772705,-0.0115748562076554,"LINC01278","long intergenic non-protein coding RNA 1278",TRUE
+"227061_at",0.531380794277271,0.0417135138370013,2.1616345433384,-3.88880189206025,2.13405868914284,"LINC01279","long intergenic non-protein coding RNA 1279",TRUE
+"1564460_at",0.622434989367596,0.0926614133654074,1.75739351636737,-4.53791841793935,0.58314786459741,"LINC01281","long intergenic non-protein coding RNA 1281",TRUE
+"1563073_at",0.910165867297668,0.626213016106281,0.493935289069093,-5.8215472460654,0.321870189919527,"LINC01282","long intergenic non-protein coding RNA 1282",TRUE
+"1560337_at",0.679430772812099,0.146737421847818,1.50386588884723,-4.89436136661076,0.884461029123363,"LINC01289","long intergenic non-protein coding RNA 1289",TRUE
+"1560240_at",0.752913428584105,0.246152283348731,-1.19127166843142,-5.27115051891629,-1.5423005110223,"LINC01293","long intergenic non-protein coding RNA 1293",TRUE
+"242546_at",0.594005743610726,0.070881461282326,1.8974151006161,-4.32354158769106,1.79707151729992,"LINC01296///DUXAP10","long intergenic non-protein coding RNA 1296///double homeobox A pseudogene 10",TRUE
+"228116_at",0.517654151778308,0.0368379953279429,2.22152835089084,-3.78524394952142,1.9476311112115,"LINC01296///DUXAP10///DUXAP8","long intergenic non-protein coding RNA 1296///double homeobox A pseudogene 10///double homeobox A pseudogene 8",TRUE
+"243762_at",0.854040699678541,0.463167601329874,-0.746577405141691,-5.67179165716682,-0.608688435444408,"LINC01297","long intergenic non-protein coding RNA 1297",TRUE
+"1569297_at",0.90344422113846,0.604150963710935,0.525945583745293,-5.8058434130844,0.412529716082639,"LINC01300","long intergenic non-protein coding RNA 1300",TRUE
+"237343_at",0.819162667476514,0.3755325493544,0.904361170246525,-5.54899242202374,0.529066331283493,"LINC01304","long intergenic non-protein coding RNA 1304",TRUE
+"1557570_a_at",0.956619372543067,0.803065574984722,-0.252390876631535,-5.90870453640663,-0.237743393039794,"LINC01305","long intergenic non-protein coding RNA 1305",TRUE
+"1557588_at",0.965584868976477,0.839006365034229,-0.205566700773523,-5.91912226241462,-0.0711709946299379,"LINC01310","long intergenic non-protein coding RNA 1310",TRUE
+"1552900_a_at",0.968317867540591,0.851321875126933,-0.189634744476558,-5.92218320303105,-0.0743747407826651,"LINC01312","long intergenic non-protein coding RNA 1312",TRUE
+"1552899_at",0.98529096111871,0.926628841038808,-0.093140740898607,-5.93545899500017,-0.0388152462795963,"LINC01312","long intergenic non-protein coding RNA 1312",TRUE
+"236709_at",0.680972290639028,0.148840861155136,-1.495698387872,-4.9051199497309,-0.745157304622644,"LINC01314","long intergenic non-protein coding RNA 1314",TRUE
+"215126_at",0.752926680499867,0.246307208183276,1.19086881110804,-5.2715879059471,0.531968801456273,"LINC01314","long intergenic non-protein coding RNA 1314",TRUE
+"214896_at",0.986944270343822,0.939885034627565,0.0762747888736298,-5.9368502209509,0.0439621993062556,"LINC01314","long intergenic non-protein coding RNA 1314",TRUE
+"229930_at",0.675622576285316,0.142083393155134,1.52228320339985,-4.86992941333761,1.11189483274179,"LINC01315","long intergenic non-protein coding RNA 1315",TRUE
+"1560168_at",0.840268837320073,0.429345162649575,0.805050909383499,-5.62885044545319,0.681118320680936,"LINC01330","long intergenic non-protein coding RNA 1330",TRUE
+"1556920_s_at",0.847288501166363,0.445942454037624,-0.776019560241027,-5.65055186664136,-0.665270599926844,"LINC01330","long intergenic non-protein coding RNA 1330",TRUE
+"1560565_at",0.831875452294783,0.407379802679402,0.844567178665207,-5.59811086950649,0.465933613807224,"LINC01333","long intergenic non-protein coding RNA 1333",TRUE
+"241327_at",0.610033432202476,0.0824800206285244,1.81883379977671,-4.44530582783603,0.900686079000576,"LINC01339","long intergenic non-protein coding RNA 1339",TRUE
+"230541_at",0.969882914559333,0.857241478767485,0.181994945029926,-5.92356376243137,0.0895190165850379,"LINC01341","long intergenic non-protein coding RNA 1341",TRUE
+"1562788_at",0.978404064916532,0.896149351676988,0.132033639817158,-5.93119613201206,0.0932477924812063,"LINC01342","long intergenic non-protein coding RNA 1342",TRUE
+"1562510_at",0.728385463227073,0.208684561950837,1.29490534696058,-5.15440561465264,0.533728376557118,"LINC01343","long intergenic non-protein coding RNA 1343",TRUE
+"1566737_at",0.675352428480841,0.141522188394209,-1.5245373272361,-4.86692286003372,-1.2504622699469,"LINC01346","long intergenic non-protein coding RNA 1346",TRUE
+"1566735_at",0.676294804179428,0.14303928880715,1.51846053642152,-4.87501998852319,0.904526073146097,"LINC01346","long intergenic non-protein coding RNA 1346",TRUE
+"241533_at",0.880814827834223,0.536454940531055,0.627951534410897,-5.74942691257019,0.465717382936549,"LINC01348","long intergenic non-protein coding RNA 1348",TRUE
+"231350_at",0.774230543658252,0.288330693085893,-1.08790330045449,-5.37910449944751,-0.669969512043563,"LINC01350","long intergenic non-protein coding RNA 1350",TRUE
+"237675_at",0.962555471240652,0.82952682688839,-0.217866862633624,-5.91659096496473,-0.19338333354199,"LINC01351","long intergenic non-protein coding RNA 1351",TRUE
+"1568852_x_at",0.484495305292367,0.0278216180239851,2.35440632086059,-3.54950258326793,1.67426867349573,"LINC01352","long intergenic non-protein coding RNA 1352",TRUE
+"1568851_at",0.82706053436911,0.395721873260892,0.866091610563455,-5.58078891943325,0.588128402278812,"LINC01352","long intergenic non-protein coding RNA 1352",TRUE
+"239822_at",0.941311073534434,0.737423818581405,0.339508455541431,-5.88369707915336,0.339024202494495,"LINC01354","long intergenic non-protein coding RNA 1354",TRUE
+"244490_at",0.8616721121598,0.483860213763698,0.71205738426586,-5.69570204267903,0.398674735637719,"LINC01355","long intergenic non-protein coding RNA 1355",TRUE
+"228387_at",0.994497624146884,0.974598577035468,-0.0322029012384421,-5.93917839582887,-0.0286752023251156,"LINC01355","long intergenic non-protein coding RNA 1355",TRUE
+"1564413_at",0.48580305784244,0.0284239790061745,2.34437589360558,-3.56757422955843,1.43531471885045,"LINC01356","long intergenic non-protein coding RNA 1356",TRUE
+"1562103_at",0.887780176248324,0.553013575540291,0.602415508261657,-5.76445525018827,0.202095477108176,"LINC01359","long intergenic non-protein coding RNA 1359",TRUE
+"237537_at",0.609532363331105,0.0817766042498829,-1.82331642024512,-4.43845873717552,-1.43956950359678,"LINC01360","long intergenic non-protein coding RNA 1360",TRUE
+"1561213_at",0.857750641191636,0.473303896537913,0.72955688648951,-5.68371531024086,0.599305171167211,"LINC01360","long intergenic non-protein coding RNA 1360",TRUE
+"242262_x_at",0.929972194057784,0.690897066444186,-0.402880575619768,-5.86093465503518,-0.280388101642988,"LINC01360","long intergenic non-protein coding RNA 1360",TRUE
+"215940_at",0.812302873476553,0.356719165777176,-0.9412649322393,-5.51712980371618,-0.619806840051052,"LINC01361","long intergenic non-protein coding RNA 1361",TRUE
+"215944_at",0.866570838305433,0.497626421770017,0.689565695625457,-5.71070099407985,0.2353665399434,"LINC01361","long intergenic non-protein coding RNA 1361",TRUE
+"1562742_at",0.758920166935337,0.256141449858876,1.16567500887028,-5.29868438049796,0.91311145007382,"LINC01362","long intergenic non-protein coding RNA 1362",TRUE
+"237760_at",0.897949253801113,0.585613438135031,0.553277620691276,-5.7916754664725,0.479272461671179,"LINC01364","long intergenic non-protein coding RNA 1364",TRUE
+"1556494_at",0.658800626791833,0.126940367686364,1.58586247880847,-4.78378070481149,0.934702413078651,"LINC01365","long intergenic non-protein coding RNA 1365",TRUE
+"1559488_at",0.743474458360704,0.23382852856871,-1.22394679720837,-5.23524730091399,-0.805392498091924,"LINC01366","long intergenic non-protein coding RNA 1366",TRUE
+"1559489_a_at",0.946257232656659,0.756506040272234,0.313936366561081,-5.8917941425771,0.243394516013236,"LINC01366","long intergenic non-protein coding RNA 1366",TRUE
+"1561795_at",0.954672574687803,0.793405297697357,-0.265070906027843,-5.90551899185155,-0.207041693981081,"LINC01393","long intergenic non-protein coding RNA 1393",TRUE
+"1563070_at",0.599810452189742,0.0763544718288176,1.85903989202209,-4.38346153922864,1.18005054204455,"LINC01395","long intergenic non-protein coding RNA 1395",TRUE
+"1568938_at",0.83030603167465,0.402467844084411,0.853587500008631,-5.59090113619471,0.262587858504945,"LINC01398","long intergenic non-protein coding RNA 1398",TRUE
+"230195_at",0.639656559005154,0.110073292864237,1.66459453091853,-4.67331170192804,1.30512215894659,"LINC01405","long intergenic non-protein coding RNA 1405",TRUE
+"243824_at",0.697699759202153,0.168452555182167,1.42374020789704,-4.99785360281088,1.20112970438009,"LINC01410","long intergenic non-protein coding RNA 1410",TRUE
+"1559835_at",0.717552284196685,0.193299619046764,1.34164886550172,-5.0990410437479,0.933289491884163,"LINC01410","long intergenic non-protein coding RNA 1410",TRUE
+"1561339_at",0.695812999227098,0.165777098879493,1.43314462514606,-4.98594552006188,0.735691668040787,"LINC01416","long intergenic non-protein coding RNA 1416",TRUE
+"1559213_at",0.736116063927188,0.221420480792804,1.25819130474272,-5.19672046851247,0.715586891239319,"LINC01419","long intergenic non-protein coding RNA 1419",TRUE
+"225028_at",0.821533954989003,0.383848311186997,-0.888439365267534,-5.5623758829325,-0.715172264005236,"LINC01420","long intergenic non-protein coding RNA 1420",TRUE
+"225029_at",0.996261754016157,0.98170652277151,0.023189717293508,-5.93942155961903,0.0146524593074417,"LINC01420","long intergenic non-protein coding RNA 1420",TRUE
+"242798_at",0.904832003218088,0.610056111265617,0.517324392442794,-5.81016741297854,0.319696849493985,"LINC01424","long intergenic non-protein coding RNA 1424",TRUE
+"1561029_at",0.983099438828965,0.917726269188606,0.104482796682503,-5.93436777908205,0.0555249732477416,"LINC01425","long intergenic non-protein coding RNA 1425",TRUE
+"232804_at",0.867972140419125,0.501363215469503,-0.683521950650672,-5.71465302544467,-0.402123680238446,"LINC01426","long intergenic non-protein coding RNA 1426",TRUE
+"1563127_at",0.915569510513076,0.643866298113332,-0.468694931663565,-5.83325062689993,-0.161199817633305,"LINC01428","long intergenic non-protein coding RNA 1428",TRUE
+"230366_at",0.85334340854827,0.460868351080305,-0.750468927910198,-5.6690288604957,-0.54231703257035,"LINC01431","long intergenic non-protein coding RNA 1431",TRUE
+"1563246_at",0.744152356003007,0.234984735736477,1.22082675277977,-5.23871192685957,0.741904421052341,"LINC01432","long intergenic non-protein coding RNA 1432",TRUE
+"1564561_at",0.990810941805126,0.95525745122623,-0.0567443662783042,-5.93811529660837,-0.0409265726508803,"LINC01442","long intergenic non-protein coding RNA 1442",TRUE
+"1562982_at",0.584247456664678,0.064827046970543,1.94301847259777,-4.25122815079973,1.34157259292208,"LINC01448","long intergenic non-protein coding RNA 1448",TRUE
+"1570224_at",0.893600768892136,0.568860881202529,-0.578349297024217,-5.77806690071516,-0.326205002896939,"LINC01449","long intergenic non-protein coding RNA 1449",TRUE
+"1557312_at",0.897320090351171,0.583541163832213,0.556359281796614,-5.79003431318958,0.171165015779511,"LINC01465","long intergenic non-protein coding RNA 1465",TRUE
+"1570234_at",0.925971111202028,0.679113225205123,0.419190307953549,-5.85445702649815,0.232153073045914,"LINC01467","long intergenic non-protein coding RNA 1467",TRUE
+"1557779_at",0.528157573856103,0.0406490547926197,2.17414796569451,-3.8673101674041,3.04162032705196,"LINC01468","long intergenic non-protein coding RNA 1468",TRUE
+"1569741_at",0.630603891142543,0.10190726744817,1.70643076950624,-4.61295406593109,0.756028659110558,"LINC01477","long intergenic non-protein coding RNA 1477",TRUE
+"217471_at",0.783963982912486,0.307032844373206,1.04557023022446,-5.42079917798986,0.316435251417269,"LINC01482","long intergenic non-protein coding RNA 1482",TRUE
+"217474_at",0.991059530537351,0.958359832257123,-0.0528058303928965,-5.93832541803594,-0.0315907174552903,"LINC01482","long intergenic non-protein coding RNA 1482",TRUE
+"1557498_a_at",0.812302873476553,0.360112373808441,-0.934514373094889,-5.52304580761825,-0.538812395113665,"LINC01487","long intergenic non-protein coding RNA 1487",TRUE
+"1559837_at",0.984360502484283,0.923813554704591,-0.0967260469931593,-5.93512758026395,-0.0789801585470311,"LINC01490","long intergenic non-protein coding RNA 1490",TRUE
+"1568919_at",0.615637099066718,0.0860317167228041,1.79669300274622,-4.47894670743469,1.36912651568352,"LINC01492","long intergenic non-protein coding RNA 1492",TRUE
+"1562116_at",0.968066640321622,0.84950567001753,0.191981021860459,-5.92174786223034,0.118419029986711,"LINC01494","long intergenic non-protein coding RNA 1494",TRUE
+"241283_at",0.978316880841318,0.895778337150959,0.132508229669253,-5.93113503330389,0.0964808400469708,"LINC01500","long intergenic non-protein coding RNA 1500",TRUE
+"229296_at",0.854184492233394,0.464718631055355,0.743958757985736,-5.67364311182347,0.876351924706358,"LINC01503","long intergenic non-protein coding RNA 1503",TRUE
+"230279_at",0.858574065957936,0.474325906159859,0.72785275243977,-5.68489475750994,0.346370050303251,"LINC01504","long intergenic non-protein coding RNA 1504",TRUE
+"1569817_at",0.778397054392363,0.298076004369852,1.06560752817481,-5.40124872782382,0.757109946151234,"LINC01505","long intergenic non-protein coding RNA 1505",TRUE
+"1561398_at",0.953404125808695,0.78533910875963,0.275692576999304,-5.90273122188851,0.179504936126608,"LINC01505","long intergenic non-protein coding RNA 1505",TRUE
+"240162_at",0.969859842767097,0.855846129780008,0.183794757292258,-5.9232436192841,0.0894524095464142,"LINC01511","long intergenic non-protein coding RNA 1511",TRUE
+"1564012_at",0.815977292327875,0.366902524301885,0.921132782863508,-5.5346573148287,0.600351639322729,"LINC01512","long intergenic non-protein coding RNA 1512",TRUE
+"1561527_at",0.961212424803935,0.823465247994158,0.225749990969225,-5.91489169345118,0.200235251909076,"LINC01514","long intergenic non-protein coding RNA 1514",TRUE
+"1561262_at",0.700963156261921,0.17271834734633,1.40899039519286,-5.01640048863483,1.04763325704644,"LINC01516","long intergenic non-protein coding RNA 1516",TRUE
+"1560862_at",0.951810226174863,0.778974463933919,0.284096495617386,-5.90044849484697,0.101551645328139,"LINC01520","long intergenic non-protein coding RNA 1520",TRUE
+"224073_at",0.830569539453807,0.402926867205721,-0.85274157757099,-5.59158029662528,-0.698611147817402,"LINC01521","long intergenic non-protein coding RNA 1521",TRUE
+"231492_at",0.843095426822889,0.437391893586305,0.790891268360615,-5.63952872944665,0.592853172180579,"LINC01523","long intergenic non-protein coding RNA 1523",TRUE
+"1562157_at",0.939976205834042,0.730255342460916,0.349173959777361,-5.88047339481751,0.125693148136748,"LINC01526","long intergenic non-protein coding RNA 1526",TRUE
+"1560760_s_at",0.695001304512766,0.164461396941677,-1.43781421971794,-4.98000895251922,-1.53133182559523,"LINC01527","long intergenic non-protein coding RNA 1527",TRUE
+"1559093_at",0.895370220688938,0.573807597758306,0.570907789000819,-5.78216704545396,0.280316105745591,"LINC01530","long intergenic non-protein coding RNA 1530",TRUE
+"1559303_at",0.790240875783718,0.319667794057348,1.0179956888898,-5.44715715442337,0.661198643574331,"LINC01532","long intergenic non-protein coding RNA 1532",TRUE
+"243060_at",0.993846586666397,0.970877755752476,-0.036922106187745,-5.93901951768255,-0.0306335947326102,"LINC01532","long intergenic non-protein coding RNA 1532",TRUE
+"1562728_at",0.85463333818278,0.466321350504859,-0.741258295136148,-5.67554595345197,-0.581447143101776,"LINC01533","long intergenic non-protein coding RNA 1533",TRUE
+"1560238_at",0.813641569007658,0.364476957189196,0.925893779630256,-5.53054374917129,0.812666115582324,"LINC01535","long intergenic non-protein coding RNA 1535",TRUE
+"1559725_at",0.906845308365483,0.615031732733321,0.510090980846878,-5.81374162988945,0.378661813263151,"LINC01537","long intergenic non-protein coding RNA 1537",TRUE
+"1561090_at",0.930065981387326,0.691263254205813,0.402375543788951,-5.86113119745012,0.284203349959871,"LINC01538","long intergenic non-protein coding RNA 1538",TRUE
+"237344_at",0.603702127972549,0.0778534764740004,1.84894865459282,-4.39907436731824,0.982242941111845,"LINC01539","long intergenic non-protein coding RNA 1539",TRUE
+"241291_at",0.896118799730606,0.578462728995069,0.563934545481445,-5.78596247895797,0.676371284902629,"LINC01541","long intergenic non-protein coding RNA 1541",TRUE
+"1563327_a_at",0.899808883319249,0.592254186946249,0.543438410817611,-5.79685612104641,0.451824993279673,"LINC01545","long intergenic non-protein coding RNA 1545",TRUE
+"1552528_at",0.729747638370823,0.212011156109183,1.28515260830639,-5.16574730816446,0.755704217097629,"LINC01547","long intergenic non-protein coding RNA 1547",TRUE
+"1555627_s_at",0.748438284778152,0.241013885203969,1.20474235680822,-5.25645115851713,0.78893720584586,"LINC01547","long intergenic non-protein coding RNA 1547",TRUE
+"1555393_s_at",0.940724219066753,0.734731924628697,-0.343134113769746,-5.88249831768862,-0.125683521718881,"LINC01547","long intergenic non-protein coding RNA 1547",TRUE
+"240801_at",0.787929163003677,0.31382142406173,1.0306576762672,-5.43513268930706,0.418481548086998,"LINC01549","long intergenic non-protein coding RNA 1549",TRUE
+"1560499_at",0.853093296743962,0.459527936297772,0.752742957000711,-5.66740811126645,0.596710855782503,"LINC01550","long intergenic non-protein coding RNA 1550",TRUE
+"1564211_at",0.853460212676856,0.461793058128333,0.748902454871031,-5.67014261814596,0.378390108319834,"LINC01550","long intergenic non-protein coding RNA 1550",TRUE
+"1559097_at",0.978316880841318,0.895679705668515,0.132634401130014,-5.93111875316179,0.0620605192289299,"LINC01550","long intergenic non-protein coding RNA 1550",TRUE
+"243061_at",0.682825347106105,0.150945302657392,1.48762069344944,-4.91571394001105,0.969036211339854,"LINC01551","long intergenic non-protein coding RNA 1551",TRUE
+"1556648_a_at",0.892780783477555,0.566030973280671,0.582621268739614,-5.77568988982341,0.506629855967773,"LINC01553","long intergenic non-protein coding RNA 1553",TRUE
+"239380_at",0.862125670830879,0.484887597501754,0.710366181517807,-5.69684579943625,0.438813014587526,"LINC01554","long intergenic non-protein coding RNA 1554",TRUE
+"1563743_at",0.730048787941067,0.212535920472501,1.28362494978184,-5.16751725043934,0.924053257626653,"LINC01555","long intergenic non-protein coding RNA 1555",TRUE
+"207698_at",0.446963972064621,0.02116233904903,2.48109504564683,-3.31759557940192,1.80011329503126,"LINC01558","long intergenic non-protein coding RNA 1558",TRUE
+"1555095_at",0.528328646587879,0.0409396827590169,2.17070228258443,-3.87323579525521,1.67999376622218,"LINC01558","long intergenic non-protein coding RNA 1558",TRUE
+"239034_at",0.606138724709726,0.0798340440853244,-1.83587163545532,-4.41921658124894,-0.544898847856728,"LINC01560","long intergenic non-protein coding RNA 1560",TRUE
+"236855_at",0.959623505183049,0.817725212216134,0.233228451213504,-5.91322410741603,0.0850363527967213,"LINC01561","long intergenic non-protein coding RNA 1561",TRUE
+"244824_at",0.932383195894321,0.701636473925486,0.388112765219166,-5.86658154934373,0.302816737839533,"LINC01563","long intergenic non-protein coding RNA 1563",TRUE
+"208440_at",0.714782078270721,0.19013791580008,1.35161330531668,-5.08702550421884,0.519891509638269,"LINC01565","long intergenic non-protein coding RNA 1565",TRUE
+"1561518_at",0.855439520086837,0.468565173981821,0.73748685340686,-5.67819246206277,0.194151392162975,"LINC01566","long intergenic non-protein coding RNA 1566",TRUE
+"1568660_a_at",0.700061364939874,0.171712250232735,1.41244267631919,-5.01207371406911,1.16736653434475,"LINC01568","long intergenic non-protein coding RNA 1568",TRUE
+"1561303_at",0.71789173952175,0.193549532485197,1.34086671154967,-5.0999810431275,0.524759326138497,"LINC01568","long intergenic non-protein coding RNA 1568",TRUE
+"229592_at",0.54775309185967,0.0481370787050888,-2.09172540115829,-4.00742835372697,-1.84352627992094,"LINC01569","long intergenic non-protein coding RNA 1569",TRUE
+"225951_s_at",0.55074985379986,0.0488977089565971,-2.08401184221496,-4.02036451987503,-0.802816597216008,"LINC01578","long intergenic non-protein coding RNA 1578",TRUE
+"230156_x_at",0.702920518369914,0.174859112397791,-1.40169778545796,-5.02551169828092,-0.585801000042409,"LINC01578","long intergenic non-protein coding RNA 1578",TRUE
+"226830_x_at",0.81390353381761,0.364828032698633,-0.925203369008099,-5.53114148345276,-0.408431245888109,"LINC01578","long intergenic non-protein coding RNA 1578",TRUE
+"244443_at",0.827864542779169,0.397072149425532,-0.863577860408629,-5.58283280832043,-0.447430385852132,"LINC01578","long intergenic non-protein coding RNA 1578",TRUE
+"1562308_at",0.925761397342164,0.67875623475547,-0.419686196402479,-5.85425611799599,-0.197744159498086,"LINC01579","long intergenic non-protein coding RNA 1579",TRUE
+"1554891_at",0.966234972055559,0.842563964566856,0.200959005562991,-5.92003278938,0.109990211569974,"LINC01580","long intergenic non-protein coding RNA 1580",TRUE
+"1561247_at",0.536559328842429,0.0434841222880805,2.14144551908696,-3.92331292297999,1.00804190766987,"LINC01581","long intergenic non-protein coding RNA 1581",TRUE
+"1559497_at",0.758406246468989,0.255393843668355,-1.16756470751871,-5.29666954850181,-0.915398531043722,"LINC01583","long intergenic non-protein coding RNA 1583",TRUE
+"1569833_at",0.429284714913652,0.0189645366098164,2.53117924356346,-3.22413156124646,0.946592636649905,"LINC01585","long intergenic non-protein coding RNA 1585",TRUE
+"207241_at",0.643515428391208,0.114010469911504,-1.64535439979292,-4.70068725921278,-1.24261248375232,"LINC01587","long intergenic non-protein coding RNA 1587",TRUE
+"237460_x_at",0.974670398319743,0.876280271525247,-0.157496201811169,-5.92760907057465,-0.080908397816617,"LINC01588","long intergenic non-protein coding RNA 1588",TRUE
+"239777_at",0.976371465776674,0.886199251459909,-0.1447726113452,-5.9294802245667,-0.119564298973622,"LINC01588","long intergenic non-protein coding RNA 1588",TRUE
+"242219_at",0.990623482682449,0.952522415447719,-0.0602173108565419,-5.93791748350875,-0.0388394428203531,"LINC01588","long intergenic non-protein coding RNA 1588",TRUE
+"230506_at",0.984244246588495,0.923506430621608,-0.0971172514888899,-5.9350906618287,-0.0692520653720972,"LINC01590","long intergenic non-protein coding RNA 1590",TRUE
+"1561881_at",0.822010986888098,0.385438109760804,-0.885421277274419,-5.56488799335262,-0.641794283117155,"LINC01592","long intergenic non-protein coding RNA 1592",TRUE
+"1564785_at",0.851319596585235,0.454765217035273,0.760855284526276,-5.66158848244621,0.388640103570303,"LINC01599","long intergenic non-protein coding RNA 1599",TRUE
+"1553363_at",0.89390639630277,0.569645567286507,-0.577166675961282,-5.77872194164578,-0.371749160073084,"LINC01600","long intergenic non-protein coding RNA 1600",TRUE
+"238377_s_at",0.429284714913652,0.0188808411454098,2.53319173986968,-3.22035578979005,0.725253296269637,"LINC01607","long intergenic non-protein coding RNA 1607",TRUE
+"238369_s_at",0.758189649141895,0.255075358937268,1.16837097868443,-5.29580901721294,0.556091421462817,"LINC01607","long intergenic non-protein coding RNA 1607",TRUE
+"1561278_at",0.597654932724127,0.0740802465172895,-1.87468459518202,-4.35913764815765,-1.26163361186274,"LINC01613","long intergenic non-protein coding RNA 1613",TRUE
+"237509_at",0.857334347030994,0.472658970691454,0.73063337162387,-5.68296891457114,0.57056256445784,"LINC01616","long intergenic non-protein coding RNA 1616",TRUE
+"1564881_at",0.707898177720919,0.179761874291876,1.38526063473215,-5.0459045748347,0.560171810725231,"LINC01618","long intergenic non-protein coding RNA 1618",TRUE
+"1564150_a_at",0.9802233499944,0.907135415060851,0.117994197165204,-5.93290455505504,0.0989889238514836,"LINC01619","long intergenic non-protein coding RNA 1619",TRUE
+"233584_at",0.456633003605056,0.0223326319458605,-2.45637079463391,-3.36337138331172,-2.20946634640818,"LINC01620","long intergenic non-protein coding RNA 1620",TRUE
+"1570328_s_at",0.762252900774908,0.261702465215732,1.15174542458475,-5.31344801262257,0.765076443652856,"LINC01620","long intergenic non-protein coding RNA 1620",TRUE
+"1570327_at",0.892895911526563,0.566495298710967,0.581919583531844,-5.77608148370531,0.384936828220925,"LINC01620","long intergenic non-protein coding RNA 1620",TRUE
+"1557618_at",0.991059530537351,0.958224533013503,-0.0529775772242365,-5.93831657028303,-0.0296253296002842,"LINC01622","long intergenic non-protein coding RNA 1622",TRUE
+"227933_at",0.540483367247649,0.0450188094783442,-2.12453805986872,-3.95205749723691,-1.80468227844486,"LINGO1","leucine rich repeat and Ig domain containing 1",TRUE
+"1562748_at",0.835223580564215,0.414281826796701,0.832008585696347,-5.6080295448446,0.349082620921228,"LINGO1-AS1","LINGO1 antisense RNA 1",TRUE
+"1561619_at",0.975398143273847,0.881787792966047,0.150428269166793,-5.92866789915679,0.0812151538598984,"LINGO1-AS2","LINGO1 antisense RNA 2",TRUE
+"232720_at",0.109049446709661,0.000518152949206843,4.0575067180005,-0.0766033768867489,1.57753120598465,"LINGO2","leucine rich repeat and Ig domain containing 2",TRUE
+"243686_at",0.620912785033482,0.0907484520607975,1.7684781168766,-4.5213818894712,0.987308549342349,"LINGO2","leucine rich repeat and Ig domain containing 2",TRUE
+"1560439_at",0.719965488428987,0.19575687153151,1.333992576632,-5.10822264025859,0.665490002944532,"LINGO3","leucine rich repeat and Ig domain containing 3",TRUE
+"237405_at",0.973066963106626,0.869490650526441,0.166220842351182,-5.92623518717558,0.113947701752141,"LINGO3","leucine rich repeat and Ig domain containing 3",TRUE
+"1554455_at",0.627092759817312,0.0989248927913522,-1.72242215833102,-4.58958592040231,-0.870780429105849,"LINS1","lines homolog 1",TRUE
+"231976_at",0.737123149977386,0.223138477811332,-1.25336394496031,-5.20220680938703,-0.45095529504311,"LINS1","lines homolog 1",TRUE
+"1554456_a_at",0.774230543658252,0.28792682261189,-1.08883890434162,-5.37816630957916,-0.369643656858356,"LINS1","lines homolog 1",TRUE
+"228348_at",0.830635993561085,0.403377362550346,-0.8519119707177,-5.59224574828281,-0.282134229422308,"LINS1","lines homolog 1",TRUE
+"220121_at",0.954456115752166,0.791245824410174,-0.267911426868361,-5.90478411991845,-0.153928388002567,"LINS1","lines homolog 1",TRUE
+"201847_at",0.316920685370514,0.00688038140895838,2.97952379436436,-2.34930293424293,1.33818743574889,"LIPA","lipase A, lysosomal acid type",TRUE
+"206606_at",0.758436363256407,0.25549465561,1.16730964917109,-5.29694166335167,0.691699952851011,"LIPC","lipase C, hepatic type",TRUE
+"1562038_at",0.744573608322482,0.235825874535867,1.21856421782775,-5.24121955468963,0.553854319534643,"LIPC-AS1","LIPC antisense RNA 1",TRUE
+"213855_s_at",0.814859344192337,0.365721690848391,0.923447936941828,-5.5326594290373,0.323981272309578,"LIPE","lipase E, hormone sensitive type",TRUE
+"208186_s_at",0.86481525165637,0.492602155435428,0.697732623093542,-5.70530783557953,0.569880533054785,"LIPE","lipase E, hormone sensitive type",TRUE
+"243703_x_at",0.694819513561858,0.164372131256927,-1.43813212245722,-4.97960422154139,-1.09827614141027,"LIPE-AS1","LIPE antisense RNA 1",TRUE
+"206334_at",0.647518308302168,0.118540506832021,1.62389666531001,-4.7309301381993,0.974983339104725,"LIPF","lipase F, gastric type",TRUE
+"219181_at",0.332429060350567,0.00813770959657953,2.90685988557303,-2.49519814733756,3.15190492053303,"LIPG","lipase G, endothelial type",TRUE
+"241898_at",0.627092759817312,0.0982519521855921,1.72608717253718,-4.58420733375611,1.13402136860322,"LIPH","lipase H",TRUE
+"235871_at",0.689989255588491,0.159506959736635,1.45567278297775,-4.95715973774229,1.03435168585384,"LIPH","lipase H",TRUE
+"242178_at",0.576718676236794,0.0614006294352881,1.97051741886896,-4.20705375024384,1.53775944662628,"LIPI","lipase I",TRUE
+"1569571_at",0.433660982257499,0.0196307440528086,2.51544933817379,-3.25359020360805,2.24118747025812,"LIPJ","lipase family member J",TRUE
+"238634_x_at",0.776181137432978,0.293706658479211,-1.07553825689125,-5.39143610397624,-1.07266224263852,"LIPJ","lipase family member J",TRUE
+"1569873_at",0.877488742289724,0.527562863522348,0.641838978243548,-5.74100186713147,0.605481529997896,"LIPJ","lipase family member J",TRUE
+"1569874_s_at",0.973499570783928,0.872484398745003,-0.162372298785066,-5.92685032914896,-0.122926390831633,"LIPJ","lipase family member J",TRUE
+"205571_at",0.913751621687959,0.63834161933373,-0.476560089006755,-5.82966811606684,-0.184926147110524,"LIPT1","lipoyltransferase 1",TRUE
+"200704_at",0.860085676417428,0.478769829665435,-0.72046772449503,-5.68997570704658,-0.262838257919462,"LITAF","lipopolysaccharide induced TNF factor",TRUE
+"200706_s_at",0.950214160603623,0.774009969462643,-0.29066615111551,-5.89861664275712,-0.116071463259562,"LITAF","lipopolysaccharide induced TNF factor",TRUE
+"1555454_at",0.994145854504594,0.97330432293385,-0.0338443434790607,-5.93912559475878,-0.0305108119645414,"LITAF","lipopolysaccharide induced TNF factor",TRUE
+"230865_at",0.957430653957785,0.807828985839157,0.246154112833427,-5.91021444178843,0.352545902103329,"LIX1","limb and CNS expressed 1",TRUE
+"236163_at",0.977160030692682,0.891066426054687,-0.138538305755994,-5.93033966659675,-0.147041093298111,"LIX1","limb and CNS expressed 1",TRUE
+"225793_at",0.732320150624823,0.216663291793189,1.27170992192186,-5.18126038054855,1.19526475528501,"LIX1L","limb and CNS expressed 1 like",TRUE
+"235036_at",0.77480482329936,0.291241421866979,1.08118807807458,-5.38581717230873,1.00494684350387,"LIX1L","limb and CNS expressed 1 like",TRUE
+"1554977_at",0.635821858586292,0.106867432744705,-1.68069479823709,-4.65021772626881,-1.06691411199481,"LKAAEAR1","LKAAEAR motif containing 1",TRUE
+"1564691_at",0.622917527985155,0.0937925853880757,1.75093102388582,-4.54752412607382,1.19515654875156,"LL0XNC01-116E7.2","uncharacterized LOC100128594",TRUE
+"1561252_at",0.950031925101785,0.77310486024997,0.291865308063445,-5.89827779234603,0.258457633378256,"LL22NC03-63E9.3","uncharacterized LOC648691",TRUE
+"1560550_at",0.909540237169823,0.624209937253283,-0.496819607548622,-5.82017167073514,-0.181119218076023,"LL22NC03-75H12.2","uncharacterized LOC101927722",TRUE
+"206124_s_at",0.463632028061434,0.0237523063217234,2.42794436050063,-3.4156971635361,0.94397115598539,"LLGL1","LLGL1, scribble cell polarity complex component",TRUE
+"206123_at",0.48580305784244,0.0284015970155794,2.34474508030266,-3.56690984977305,1.04951476368585,"LLGL1","LLGL1, scribble cell polarity complex component",TRUE
+"236594_at",0.515810181619652,0.0361921304057694,2.22999625865431,-3.77046352707782,0.829650931407455,"LLGL1","LLGL1, scribble cell polarity complex component",TRUE
+"227302_s_at",0.741260241503758,0.231712939785955,1.22968614109801,-5.22885414762889,0.620756569557943,"LLGL1///FLII","LLGL1, scribble cell polarity complex component///FLII, actin remodeling protein",TRUE
+"203713_s_at",0.942303845415102,0.740701448692981,-0.335100131685786,-5.88513765010696,-0.23627723915866,"LLGL2","LLGL2, scribble cell polarity complex component",TRUE
+"1554006_a_at",0.981836322577249,0.913067056158884,-0.110424233061476,-5.93374621557279,-0.104418343868099,"LLGL2","LLGL2, scribble cell polarity complex component",TRUE
+"209779_at",0.677013732819214,0.144189053736376,1.51389022854386,-4.88109278214286,0.701063798126098,"LLPH","LLP homolog, long-term synaptic facilitation",TRUE
+"224446_at",0.821424121108148,0.382917165510149,-0.89021085894221,-5.56089768921142,-0.304931405993065,"LLPH","LLP homolog, long-term synaptic facilitation",TRUE
+"242273_at",0.904381089098038,0.607989675009546,-0.52033672886534,-5.80866447375244,-0.257986964612019,"LLPH","LLP homolog, long-term synaptic facilitation",TRUE
+"203293_s_at",0.943935803049268,0.748829840355902,-0.324196610320974,-5.88862072548177,-0.265249376328276,"LMAN1","lectin, mannose binding 1",TRUE
+"203294_s_at",0.978928101156583,0.897300459384217,-0.130561376976561,-5.93138427860119,-0.0997806747527967,"LMAN1","lectin, mannose binding 1",TRUE
+"224629_at",0.986297868425719,0.933017512047795,0.0850092414910558,-5.93616429725089,0.0311966202360132,"LMAN1","lectin, mannose binding 1",TRUE
+"220420_at",0.754277471651057,0.24754924465124,1.18764593215592,-5.27508238375221,0.481189250693197,"LMAN1L","lectin, mannose binding 1 like",TRUE
+"200805_at",0.714820080026392,0.190604218652135,-1.35013555169726,-5.08881214273799,-0.499327699069591,"LMAN2","lectin, mannose binding 2",TRUE
+"215656_at",0.831182446031643,0.40531432863105,0.848351701135657,-5.59509468659001,0.606935431837216,"LMAN2","lectin, mannose binding 2",TRUE
+"221274_s_at",0.964181293782946,0.835367437246663,-0.210284445387767,-5.91816869079078,-0.0681080687980842,"LMAN2L","lectin, mannose binding 2 like",TRUE
+"236357_at",0.801587742916188,0.338737831271212,0.977782623364592,-5.48445129907055,0.295616294398387,"LMBR1","limb development membrane protein 1",TRUE
+"242035_at",0.819018525257656,0.373388779279646,-0.908503334423155,-5.54547461534196,-0.384280421765562,"LMBR1","limb development membrane protein 1",TRUE
+"222506_at",0.821424121108148,0.382872951703988,-0.890295045290111,-5.56082737342189,-0.525965554561667,"LMBR1","limb development membrane protein 1",TRUE
+"224036_s_at",0.827313679098971,0.396087309205433,-0.865410748835532,-5.58134306251139,-0.473260085444691,"LMBR1","limb development membrane protein 1",TRUE
+"224410_s_at",0.829803290928719,0.401493586228769,-0.85538498724309,-5.5894559157948,-0.464501163309908,"LMBR1","limb development membrane protein 1",TRUE
+"222505_at",0.895370220688938,0.573779386068796,-0.570950136189495,-5.78214385840525,-0.301719178154322,"LMBR1","limb development membrane protein 1",TRUE
+"220036_s_at",0.998870448604467,0.99641311775629,0.00454649997862711,-5.93967341283675,0.00116638755734044,"LMBR1L","limb development membrane protein 1 like",TRUE
+"232980_at",0.865885012497452,0.496339165146717,0.691653625845778,-5.70932796454052,0.632830533350794,"LMBRD1","LMBR1 domain containing 1",TRUE
+"218191_s_at",0.883375480391535,0.541335079479074,0.620382538101528,-5.75394407523107,0.242398191880007,"LMBRD1","LMBR1 domain containing 1",TRUE
+"236138_at",0.786455312223125,0.312215262153137,1.03416525232739,-5.43177799568002,0.535336132152191,"LMBRD2","LMBR1 domain containing 2",TRUE
+"226779_at",0.863982129426672,0.490494680280062,0.701172504960498,-5.70301812354643,0.322807563035779,"LMBRD2","LMBR1 domain containing 2",TRUE
+"232893_at",0.986342822130003,0.934146831852268,-0.0835724700503941,-5.93628223007206,-0.0403090409857807,"LMBRD2","LMBR1 domain containing 2",TRUE
+"218574_s_at",0.16767133696705,0.00137915218361732,-3.65569202676063,-0.939955795692999,-2.53855933032254,"LMCD1","LIM and cysteine rich domains 1",TRUE
+"227317_at",0.784789297644843,0.309104793999567,-1.04099428865625,-5.42521715519782,-0.360825151352258,"LMCD1","LIM and cysteine rich domains 1",TRUE
+"242767_at",0.949503174041699,0.771848137941857,-0.293531033825188,-5.89780480594154,-0.124598461837588,"LMCD1","LIM and cysteine rich domains 1",TRUE
+"46142_at",0.475332226369346,0.0262638985982953,-2.381303907686,-3.50082703621906,-1.91939376611399,"LMF1","lipase maturation factor 1",TRUE
+"219136_s_at",0.560923390313819,0.0544877621296497,-2.03040704496012,-4.10940212544535,-2.37477838853291,"LMF1","lipase maturation factor 1",TRUE
+"219135_s_at",0.641326159307468,0.111841325144851,-1.65588397029393,-4.68573549443531,-1.71977572238424,"LMF1","lipase maturation factor 1",TRUE
+"1558463_s_at",0.704148059811236,0.176066683374694,1.39761551322256,-5.03059495854854,0.865369909451461,"LMF1","lipase maturation factor 1",TRUE
+"242533_at",0.851319596585235,0.454606561472603,0.761126398966196,-5.6613929712682,0.183355444358777,"LMF1","lipase maturation factor 1",TRUE
+"1569048_s_at",0.904832003218088,0.609399604967659,-0.518280884387179,-5.80969111354126,-0.219140127455013,"LMF1","lipase maturation factor 1",TRUE
+"227984_at",0.973433731874338,0.871527941453264,-0.16360157454123,-5.92665540681576,-0.162088323762199,"LMF1","lipase maturation factor 1",TRUE
+"1569871_at",0.984055193758035,0.921727198586859,0.0993838859355854,-5.93487382664245,0.0370688468144742,"LMF1","lipase maturation factor 1",TRUE
+"1569872_a_at",0.998870448604467,0.995717667130743,0.00542801653220676,-5.93966913024125,0.00365741474873094,"LMF1","lipase maturation factor 1",TRUE
+"212682_s_at",0.932739823750021,0.702847018286787,-0.386453697675969,-5.8672029594357,-0.221505286040857,"LMF2","lipase maturation factor 2",TRUE
+"31837_at",0.934283509040375,0.709073078412638,-0.377938097725812,-5.87035119981653,-0.128265798881028,"LMF2","lipase maturation factor 2",TRUE
+"229611_at",0.730048787941067,0.212500509581083,-1.28372794390337,-5.16739797799232,-1.08561028563388,"LMLN","leishmanolysin like peptidase",TRUE
+"244881_at",0.821399275629351,0.382733753012041,0.890560131452352,-5.56060592268375,0.448822773651246,"LMLN","leishmanolysin like peptidase",TRUE
+"1553284_s_at",0.870808709484996,0.51005356493332,0.669564197856218,-5.72365289035511,0.360341560347823,"LMLN","leishmanolysin like peptidase",TRUE
+"238037_at",0.932091525948902,0.700312461490333,-0.389928613123204,-5.86589840944296,-0.183019331799609,"LMLN","leishmanolysin like peptidase",TRUE
+"244225_x_at",0.763494494236835,0.263230259021186,1.14795688328004,-5.31743642407379,0.463140858797535,"LMNA","lamin A/C",TRUE
+"214213_x_at",0.817517099085723,0.369964802609567,0.915151874155139,-5.53979721158068,0.258299358577178,"LMNA","lamin A/C",TRUE
+"212089_at",0.903220363604305,0.603204176619069,-0.527331585274678,-5.80514176409769,-0.245023519033412,"LMNA","lamin A/C",TRUE
+"212086_x_at",0.914588178928864,0.640198136737829,0.4739136960976,-5.83088003778324,0.181245306905998,"LMNA","lamin A/C",TRUE
+"1554600_s_at",0.940044918888428,0.73099980495745,0.348168611947205,-5.88081287115276,0.135320123905265,"LMNA","lamin A/C",TRUE
+"203411_s_at",0.942855851720963,0.743887573463121,0.33082136184018,-5.88651807223954,0.126969629340392,"LMNA","lamin A/C",TRUE
+"203276_at",0.625618384908995,0.0968378306627312,-1.73385921385171,-4.57277333652901,-0.641202740940713,"LMNB1","lamin B1",TRUE
+"216952_s_at",0.9116561917482,0.63060195133504,0.487630252506411,-5.82452696685043,0.207475477560713,"LMNB2","lamin B2",TRUE
+"1552865_a_at",0.860994442844737,0.48104405296033,0.716703851017833,-5.69254631957301,0.258412910775119,"LMNTD1","lamin tail domain containing 1",TRUE
+"236050_at",0.725127644983527,0.203181628187428,-1.31130639799466,-5.13516850821182,-0.406161595711178,"LMNTD2","lamin tail domain containing 2",TRUE
+"206718_at",0.985655660729344,0.930689696219718,0.0879713755129649,-5.93591482009,0.0731191993126332,"LMO1","LIM domain only 1",TRUE
+"204249_s_at",0.622434989367596,0.0928604783926624,1.75625135207522,-4.5396180039111,1.38419137083969,"LMO2","LIM domain only 2",TRUE
+"231049_at",0.778295711796067,0.297824634875757,1.06617601334095,-5.4006892019232,0.640149022302619,"LMO2","LIM domain only 2",TRUE
+"231348_s_at",0.82849258297242,0.398585622359516,0.860766835784969,-5.58511185950451,0.553558234814688,"LMO3","LIM domain only 3",TRUE
+"1565937_a_at",0.954054753819891,0.788933699249093,0.270955241459908,-5.90398802019876,0.167031252449803,"LMO3","LIM domain only 3",TRUE
+"1565936_a_at",0.975242094553739,0.879673573227609,-0.153140549586864,-5.92826731391382,-0.134382454089537,"LMO3","LIM domain only 3",TRUE
+"204424_s_at",0.983935461205724,0.921363203481621,0.0998476591100477,-5.93482884437895,0.112413906343223,"LMO3","LIM domain only 3",TRUE
+"209204_at",0.704585733228405,0.17652337217673,1.39607746116124,-5.03250697048211,0.542560249833141,"LMO4","LIM domain only 4",TRUE
+"241922_at",0.739367922105944,0.227211590556297,1.24203146350529,-5.21501510694219,0.477625981136208,"LMO4","LIM domain only 4",TRUE
+"227155_at",0.89961817630669,0.590568836550012,0.545930324999488,-5.79555258912534,0.521140113885163,"LMO4","LIM domain only 4",TRUE
+"209205_s_at",0.902229953331547,0.600901459939712,0.530706907844379,-5.80342552325335,0.342783449924594,"LMO4","LIM domain only 4",TRUE
+"229537_at",0.952041062962677,0.780595952683462,0.281953511397807,-5.90103704717373,0.127077855716221,"LMO4","LIM domain only 4",TRUE
+"202674_s_at",0.304824368772306,0.00603169344315767,3.03617016384656,-2.23463302691519,1.87419506123479,"LMO7","LIM domain 7",TRUE
+"242722_at",0.389015468142133,0.012935164537401,2.70323619471377,-2.89601600919439,2.37990138422641,"LMO7","LIM domain 7",TRUE
+"1556377_s_at",0.61760967235709,0.0877564811840639,1.78622457138397,-4.4947483898568,1.01866786395406,"LMO7","LIM domain 7",TRUE
+"241140_at",0.675447258877226,0.141715753252319,1.52375903087116,-4.86796135309532,0.819459137901244,"LMO7","LIM domain 7",TRUE
+"239553_at",0.73957587762701,0.227846604912576,-1.24027867525327,-5.21698722532839,-0.973465847411211,"LMO7DN","LMO7 downstream neighbor",TRUE
+"211562_s_at",0.90360437116293,0.604796834590131,0.525000691628614,-5.80632072429849,0.306909175719427,"LMOD1","leiomodin 1",TRUE
+"203766_s_at",0.951810226174863,0.779144259285774,0.283872027974914,-5.90051035030087,0.193800157310745,"LMOD1","leiomodin 1",TRUE
+"239057_at",0.953622331321215,0.786490194475617,-0.274174856964288,-5.90313622203225,-0.16186519481339,"LMOD2","leiomodin 2",TRUE
+"1564469_at",0.831893282610777,0.407844525658562,0.843717364103597,-5.59878642325714,0.816226104449091,"LMOD3","leiomodin 3",TRUE
+"243346_at",0.873230718105642,0.517881310998636,0.657105345855193,-5.7315360361299,0.702118935929376,"LMOD3","leiomodin 3",TRUE
+"1555567_s_at",0.885029460971826,0.546067963354264,0.613076647385338,-5.75825414868323,0.486249912939601,"LMOD3","leiomodin 3",TRUE
+"206223_at",0.678772326285111,0.146366925253218,1.50531439433158,-4.89244843138538,0.457681470532087,"LMTK2","lemur tyrosine kinase 2",TRUE
+"235307_at",0.697699759202153,0.168449281804693,1.42375164055965,-4.99783916552057,1.07247126278782,"LMTK2","lemur tyrosine kinase 2",TRUE
+"226375_at",0.91704891241952,0.648884230241723,0.461577122824023,-5.83644240840502,0.164386599324519,"LMTK2","lemur tyrosine kinase 2",TRUE
+"1557103_a_at",0.744931128252932,0.236660608173624,-1.21632493598588,-5.24369744667607,-0.873505151721464,"LMTK3","lemur tyrosine kinase 3",TRUE
+"1553541_at",0.859486825765374,0.477159598341806,-0.723138995005083,-5.6881435408841,-0.48692105063758,"LMX1A","LIM homeobox transcription factor 1 alpha",TRUE
+"208487_at",0.804966190665093,0.34404859231434,-0.966862619403661,-5.49434239035128,-0.894044027713809,"LMX1B","LIM homeobox transcription factor 1 beta",TRUE
+"227181_at",0.96287357728432,0.831651377322632,-0.21510723340991,-5.91717161946849,-0.0900081380644728,"LNP1","leukemia NUP98 fusion partner 1",TRUE
+"236728_at",0.55937703282623,0.0535107839932162,-2.03941005521167,-4.0945544610226,-1.80593777558946,"LNPEP","leucyl and cystinyl aminopeptidase",TRUE
+"207904_s_at",0.879447209955825,0.53388138968251,0.631957959231914,-5.74701454368366,0.27096005159075,"LNPEP","leucyl and cystinyl aminopeptidase",TRUE
+"225176_at",0.943657874590269,0.747970760148486,0.325347074642775,-5.88825859607567,0.126905994150745,"LNPEP","leucyl and cystinyl aminopeptidase",TRUE
+"243532_at",0.98529096111871,0.926859723897467,0.0928467645257464,-5.93548561453508,0.0639357699047425,"LNPEP","leucyl and cystinyl aminopeptidase",TRUE
+"231866_at",0.990810941805126,0.954791149292198,-0.0573364240389852,-5.93808240434556,-0.0289489013060198,"LNPEP","leucyl and cystinyl aminopeptidase",TRUE
+"225717_at",0.280199223932988,0.00466383414221569,-3.14603406012062,-2.01008828699182,-0.991002783063278,"LNPK","lunapark, ER junction formation factor",TRUE
+"229173_at",0.623503825356688,0.0942377065547281,-1.74840630889903,-4.55126971158344,-0.560334932362,"LNPK","lunapark, ER junction formation factor",TRUE
+"225718_at",0.726535590042475,0.205603988376051,-1.30404478083547,-5.14371110155436,-0.421365517498804,"LNPK","lunapark, ER junction formation factor",TRUE
+"223612_s_at",0.424010380516768,0.0178975663884981,-2.55748058789567,-3.17466544843813,-2.20080826695981,"LNX1","ligand of numb-protein X 1",TRUE
+"223611_s_at",0.878278790222455,0.531007414377529,-0.636444421613472,-5.74429561426551,-0.446664094932178,"LNX1","ligand of numb-protein X 1",TRUE
+"227569_at",0.812302873476553,0.358873936791091,-0.936973185872181,-5.52089549945254,-0.494917283359124,"LNX2","ligand of numb-protein X 2",TRUE
+"236886_at",0.534256384815859,0.0423819742670949,2.15392317869526,-3.90200759534172,0.62010151499185,"LOC100049716","uncharacterized LOC100049716",TRUE
+"228647_at",0.583669389655723,0.0646664363677407,1.94427847421841,-4.24921335860509,1.12710432811899,"LOC100049716","uncharacterized LOC100049716",TRUE
+"1554318_at",0.380084968057051,0.0117442707533318,2.74606838685023,-2.81275958307811,0.850462918914962,"LOC100101148///LOC541473","FK506 binding protein 6, 36kDa pseudogene///FK506 binding protein 6, 36kDa pseudogene",TRUE
+"236102_at",0.77547560202111,0.292590715720906,1.07809153758263,-5.38890003937697,0.404514708689077,"LOC100126784","uncharacterized LOC100126784",TRUE
+"239141_at",0.841550580403629,0.433151404170449,0.798332891629092,-5.63393895003502,0.379926466733025,"LOC100126784","uncharacterized LOC100126784",TRUE
+"240407_at",0.864829185767069,0.492780497619856,0.697441915491148,-5.70550084900047,0.77386444480419,"LOC100126784","uncharacterized LOC100126784",TRUE
+"207465_at",0.900535738777606,0.595521906342492,-0.538616728013323,-5.79936190546874,-0.488658545016032,"LOC100127886","uncharacterized LOC100127886",TRUE
+"1570040_at",0.982909728377256,0.917073866781354,0.105314504395321,-5.93428283647326,0.0788241447584275,"LOC100127938","KIAA1191 pseudogene",TRUE
+"1564299_at",0.728748773429537,0.210287506143536,1.29019102401671,-5.15989711518966,1.50024864622046,"LOC100127940","uncharacterized LOC100127940",TRUE
+"1563709_at",0.762857166457304,0.262598231782403,1.14952217721217,-5.31578995157935,0.482485211564634,"LOC100127955","uncharacterized LOC100127955",TRUE
+"217655_at",0.50851113795068,0.03368682837965,2.26420229359104,-3.7104150412925,2.02558822825119,"LOC100127972","uncharacterized LOC100127972",TRUE
+"1560419_at",0.983498417373669,0.919442510941822,-0.102295224523318,-5.93458798464663,-0.0770261858405661,"LOC100127974","uncharacterized LOC100127974",TRUE
+"243053_x_at",0.954577684533304,0.792771741276129,-0.265904039381471,-5.90530425795776,-0.180098226607522,"LOC100128079","uncharacterized LOC100128079",TRUE
+"1569620_s_at",0.979124488698146,0.898641545602056,0.128846504688229,-5.93160077374743,0.0980615209197926,"LOC100128079","uncharacterized LOC100128079",TRUE
+"243957_at",0.889027088154226,0.556554534491867,-0.59700738025836,-5.76756075905852,-0.393407070148731,"LOC100128108","putative ubiquitin-conjugating enzyme E2Q2-like protein",TRUE
+"237635_at",0.969882914559333,0.856814496415814,0.182545629151645,-5.92346614244585,0.09904369271558,"LOC100128164","four and a half LIM domains 1 pseudogene",TRUE
+"224095_at",0.96479405380661,0.83705551081314,0.208095315677885,-5.91861384678275,0.142615996468296,"LOC100128175","uncharacterized LOC100128175",TRUE
+"224294_at",0.966561892743893,0.843910026601816,0.199216792237737,-5.92037171161457,0.139309669382826,"LOC100128185","PNAS-19",TRUE
+"239564_at",0.675622576285316,0.141954183156006,-1.52280153724141,-4.86923837262875,-1.20442011100053,"LOC100128198","uncharacterized LOC100128198",TRUE
+"1560617_at",0.714795139167042,0.190453264406344,1.35061362689159,-5.08823431764729,0.97016875836538,"LOC100128198","uncharacterized LOC100128198",TRUE
+"238872_at",0.968265867104331,0.850728042504945,-0.190401770837767,-5.92204147177495,-0.0950871798993078,"LOC100128239","uncharacterized LOC100128239",TRUE
+"1565722_at",0.766550448794594,0.267570426453719,1.13728204661926,-5.32861219401145,0.535663716707376,"LOC100128281","uncharacterized LOC100128281",TRUE
+"1565723_at",0.848675503667458,0.449103399133252,0.770565911141677,-5.65454473517987,0.233861347202061,"LOC100128281","uncharacterized LOC100128281",TRUE
+"1559045_at",0.897949253801113,0.586512129863004,0.551942867784653,-5.79238354879312,0.433857816954189,"LOC100128288","uncharacterized LOC100128288",TRUE
+"243171_at",0.622434989367596,0.0928984190591609,1.75603390034329,-4.53994148849596,0.929405495458258,"LOC100128325","uncharacterized LOC100128325",TRUE
+"1568929_at",0.724970327905974,0.202526856382655,1.31328079167504,-5.13283888753907,0.398506618635775,"LOC100128343","uncharacterized LOC100128343",TRUE
+"242207_at",0.743691268970614,0.234403870839883,-1.22239277010644,-5.23697391229264,-0.313435117610235,"LOC100128361///CENPP","uncharacterized LOC100128361///centromere protein P",TRUE
+"1561294_a_at",0.977874971442423,0.893044263503893,-0.136006537526169,-5.93067790909115,-0.103038699499614,"LOC100128554","uncharacterized LOC100128554",TRUE
+"243523_at",0.7768734672127,0.294734470132898,1.07319276615922,-5.39376104331362,0.443585005652634,"LOC100128644","LMNE6487",TRUE
+"236053_at",0.962555471240652,0.829228310048528,-0.218254751456818,-5.91650875853666,-0.0758379265868951,"LOC100128653","uncharacterized LOC100128653",TRUE
+"240395_at",0.853768202875953,0.462532589363628,-0.74765102040018,-5.67103080035332,-0.591866255438297,"LOC100128727///DGKI","uncharacterized LOC100128727///diacylglycerol kinase iota",TRUE
+"232623_at",0.632977954834093,0.104302008920212,1.69387593000746,-4.63118577553886,0.497641071417794,"LOC100128751","INM04",TRUE
+"1562783_at",0.640839095542136,0.111361350082891,1.65823711112892,-4.6823841291699,1.56637626038997,"LOC100128840","uncharacterized LOC100128840",TRUE
+"1561940_at",0.38316799526015,0.0121724355973955,2.73021441409856,-2.84364532872218,1.41452679586412,"LOC100128843///CHFR","uncharacterized LOC100128843///checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase",TRUE
+"224362_at",0.940044918888428,0.731036631630465,0.348118889439956,-5.88082963587108,0.261755426522265,"LOC100128922","connexin",TRUE
+"232849_at",0.891918115867831,0.562002517609255,-0.588721505092748,-5.7722662555424,-0.358531901561683,"LOC100128988","uncharacterized LOC100128988",TRUE
+"1560595_at",0.827011327018402,0.395436768855648,0.866623084618463,-5.58035607909342,0.647667359376911,"LOC100128993","uncharacterized LOC100128993",TRUE
+"225214_at",0.212348514754308,0.0025247322246686,-3.40461393483496,-1.47208180305664,-1.3524259608693,"LOC100129034","uncharacterized LOC100129034",TRUE
+"244823_at",0.956734254923335,0.80390038386758,-0.2512971235767,-5.90897204655215,-0.191896711852706,"LOC100129034","uncharacterized LOC100129034",TRUE
+"234121_at",0.867972140419125,0.501322940388535,0.6835869535714,-5.7146106966191,0.348887469405072,"LOC100129069","uncharacterized LOC100129069",TRUE
+"1569361_a_at",0.839519981963042,0.427534903058951,-0.808258992891759,-5.6264063816809,-0.700761527125701,"LOC100129098","translation initiation factor IF-2",TRUE
+"241180_at",0.849935057946582,0.451449331398149,-0.766533458239096,-5.65747998133484,-0.612355382003146,"LOC100129112","uncharacterized LOC100129112",TRUE
+"1559871_s_at",0.620912785033482,0.0909434502343572,-1.76733906894958,-4.52308469556552,-1.06288112700783,"LOC100129129","uncharacterized LOC100129129",TRUE
+"1559870_at",0.832758870942732,0.409620897685625,-0.84047467544589,-5.60135834071752,-0.371006545236056,"LOC100129129","uncharacterized LOC100129129",TRUE
+"1557879_at",0.915078108213431,0.642152155522004,0.471132022714094,-5.83214679208059,0.309209454600323,"LOC100129175","uncharacterized LOC100129175",TRUE
+"223848_at",0.97928472590149,0.899101555274404,0.12825837302819,-5.93167436468287,0.0859658761856119,"LOC100129198","PRO2866",TRUE
+"236722_at",0.996771621728225,0.983679389990287,-0.0206884176610977,-5.9394750147043,-0.00476320868359714,"LOC100129380","uncharacterized LOC100129380",TRUE
+"240868_at",0.627053909308516,0.0977969012903316,1.72857765997785,-4.58054756339103,1.1737061556452,"LOC100129406","uncharacterized LOC100129406",TRUE
+"1559618_at",0.813641569007658,0.364505470347939,0.925837690260284,-5.53059232477408,0.3159018795545,"LOC100129447","uncharacterized LOC100129447",TRUE
+"224256_at",0.800179799309599,0.335820482912469,0.983831293732578,-5.47892898036856,0.605965982199474,"LOC100129449","PRO2055",TRUE
+"1560475_at",0.992376456171815,0.964414460335455,-0.0451217630607728,-5.93869188177482,-0.026452359987462,"LOC100129455","uncharacterized LOC100129455",TRUE
+"1561602_at",0.580213855105644,0.062822942207401,-1.95894201732372,-4.225700100174,-1.12491400891788,"LOC100129476","uncharacterized LOC100129476",TRUE
+"216107_at",0.843155630388418,0.437577339044744,0.790566847295453,-5.63977129792202,0.334768165734769,"LOC100129503","uncharacterized LOC100129503",TRUE
+"239643_at",0.92466349766724,0.674146069392072,-0.426099764180073,-5.85163663378985,-0.230168195916392,"LOC100129516","uncharacterized LOC100129516",TRUE
+"215223_s_at",0.559434208511607,0.0540025738266375,2.03485997998974,-4.10206381338913,1.01292132181051,"LOC100129518///SOD2","uncharacterized LOC100129518///superoxide dismutase 2, mitochondrial",TRUE
+"215078_at",0.586168493787511,0.0659914875340653,1.93396473976192,-4.26567903667185,1.47937746735169,"LOC100129518///SOD2","uncharacterized LOC100129518///superoxide dismutase 2, mitochondrial",TRUE
+"216841_s_at",0.678455276397227,0.145971226430416,1.50686474566182,-4.89039936235275,0.687336147379927,"LOC100129518///SOD2","uncharacterized LOC100129518///superoxide dismutase 2, mitochondrial",TRUE
+"221477_s_at",0.759046106067723,0.25667688458414,1.16432412387493,-5.30012296657284,0.611875090343757,"LOC100129518///SOD2","uncharacterized LOC100129518///superoxide dismutase 2, mitochondrial",TRUE
+"229699_at",0.812302873476553,0.358321256507876,0.938072325843954,-5.51993258904926,0.3785739872909,"LOC100129550","uncharacterized LOC100129550",TRUE
+"1563324_at",0.947926063538122,0.762936915725484,0.305367101218035,-5.89436707834529,0.157343823067904,"LOC100129603","uncharacterized LOC100129603",TRUE
+"238086_at",0.557512088623721,0.0523182420693553,2.05060043914957,-4.07603915758205,0.548239840114205,"LOC100129617///CMIP","uncharacterized LOC100129617///c-Maf inducing protein",TRUE
+"1563904_at",0.988776423002819,0.945964438628978,0.0685477966805115,-5.93739512742526,0.0681147867262069,"LOC100129620","uncharacterized LOC100129620",TRUE
+"234757_at",0.831013183269159,0.405016652215736,0.848898141295342,-5.59465814630529,0.333829120886343,"LOC100129884","uncharacterized LOC100129884",TRUE
+"1559528_at",0.978316880841318,0.895817618907782,-0.13245798023563,-5.93114151277642,-0.0900807173782798,"LOC100129917","uncharacterized LOC100129917",TRUE
+"62212_at",0.71454754703986,0.189752914077283,-1.35283556009215,-5.08554653446395,-0.303057026839697,"LOC100129924///C1orf50","uncharacterized LOC100129924///chromosome 1 open reading frame 50",TRUE
+"232616_at",0.946257232656659,0.756520763296159,0.313916720675798,-5.89180012195896,0.169011874707307,"LOC100129935","lectin, galactoside binding soluble 14 pseudogene",TRUE
+"215229_at",0.89316156038085,0.56719684009133,0.580859978329408,-5.77667195863648,0.279365537335789,"LOC100129973","uncharacterized LOC100129973",TRUE
+"1562627_at",0.76912869907427,0.274910453416628,1.11951461559886,-5.34700897358615,0.63210686282079,"LOC100130078","uncharacterized LOC100130078",TRUE
+"1557405_at",0.780105567875613,0.301498139090619,-1.05790199141545,-5.40880644459377,-0.841580410916536,"LOC100130111","uncharacterized LOC100130111",TRUE
+"1557406_s_at",0.784918343662568,0.309600936212984,1.03990176760186,-5.4262693827479,0.523862045788879,"LOC100130111","uncharacterized LOC100130111",TRUE
+"239864_at",0.76159330462167,0.260746447515278,1.15412442166969,-5.31093760470987,0.738482720204559,"LOC100130175///BBIP1","uncharacterized LOC100130175///BBSome interacting protein 1",TRUE
+"236043_at",0.968980656821882,0.853413848185683,0.186933562732428,-5.92267778840266,0.145960797847366,"LOC100130175///BBIP1","uncharacterized LOC100130175///BBSome interacting protein 1",TRUE
+"1559735_at",0.792436690618566,0.323840251292501,1.00905776913045,-5.45556410972014,0.414913811093485,"LOC100130207","uncharacterized LOC100130207",TRUE
+"236042_at",0.812302873476553,0.360535996706642,-0.933674608352362,-5.52377901869321,-0.482303351331798,"LOC100130219","uncharacterized LOC100130219",TRUE
+"239860_at",0.756198431607818,0.251056390158875,-1.17861027347946,-5.28483544568469,-0.898326318018139,"LOC100130232","LP2209",TRUE
+"1564444_at",0.859606387881943,0.477606270710154,-0.722397466784517,-5.68865278534708,-0.205615767564006,"LOC100130264","uncharacterized LOC100130264",TRUE
+"1563793_at",0.896118635245982,0.57826927595902,-0.564223767861245,-5.78580595842728,-0.390015396116353,"LOC100130278","uncharacterized LOC100130278",TRUE
+"1562799_at",0.990918916504081,0.957420315515397,-0.0539984727413262,-5.93826338478614,-0.029607758799397,"LOC100130285","uncharacterized LOC100130285",TRUE
+"215970_at",0.864372848707076,0.491700490909693,0.699203310377154,-5.70433020635171,0.463706390695589,"LOC100130331","POTE ankyrin domain family, member F pseudogene",TRUE
+"1559507_at",0.683527823319194,0.152470147840894,1.4818248431522,-4.92328680692602,0.935697828519451,"LOC100130357","uncharacterized LOC100130357",TRUE
+"234845_at",0.946416600885596,0.757854776911451,0.312137181852562,-5.89234020132718,0.174775372132546,"LOC100130370","uncharacterized LOC100130370",TRUE
+"234846_at",0.963407190044049,0.83319083641944,0.213108661525927,-5.91758753882008,0.117333380135564,"LOC100130370","uncharacterized LOC100130370",TRUE
+"1555980_a_at",0.170374697680568,0.00142420977297745,-3.64241374299061,-0.968281070642932,-3.05143783315643,"LOC100130417","uncharacterized LOC100130417",TRUE
+"1555979_at",0.759477583948364,0.257048608888239,-1.16338750444451,-5.30111953423339,-1.04082404765093,"LOC100130417","uncharacterized LOC100130417",TRUE
+"236059_at",0.847093798440272,0.445767541188611,-0.776322026639637,-5.65032963932758,-0.445328888089284,"LOC100130428","IGYY565",TRUE
+"241851_x_at",0.645989188983739,0.117087386608667,-1.63070363789901,-4.72136934243002,-0.818423089472677,"LOC100130429","uncharacterized LOC100130429",TRUE
+"244518_at",0.88020017258149,0.535460648690069,0.629498187189045,-5.74849738395263,0.207778072153677,"LOC100130452","uncharacterized LOC100130452",TRUE
+"1564021_at",0.674409131413512,0.140790230012873,-1.52748835182427,-4.86298142858485,-0.715289424164227,"LOC100130456","uncharacterized LOC100130456",TRUE
+"239214_at",0.877223961993707,0.526558997872364,-0.643414751927888,-5.74003470721179,-0.394998654997171,"LOC100130458","uncharacterized LOC100130458",TRUE
+"240211_at",0.707898177720919,0.179721634976819,1.38539408278461,-5.04573981335336,0.73581485080509,"LOC100130468///APCDD1","uncharacterized LOC100130468///APC down-regulated 1",TRUE
+"243871_at",0.245764881224502,0.00335468241942168,3.2854173155821,-1.7215776604799,2.85964697717896,"LOC100130476","uncharacterized LOC100130476",TRUE
+"244744_at",0.526253358601247,0.0395229227713932,2.18771362993385,-3.84392448400745,1.07634827302596,"LOC100130502","uncharacterized LOC100130502",TRUE
+"1570568_at",0.863559206655094,0.488672499168358,0.704153573804623,-5.7010251299723,0.375970600608906,"LOC100130502","uncharacterized LOC100130502",TRUE
+"237039_at",0.994825233837873,0.975873196308533,0.0305864495791135,-5.93922782841426,0.0189269837101409,"LOC100130502","uncharacterized LOC100130502",TRUE
+"1557734_s_at",0.778397054392363,0.298241531093655,1.06523336777263,-5.40161684566298,0.860405695467316,"LOC100130548","uncharacterized LOC100130548",TRUE
+"243970_at",0.912457981072444,0.633331358166316,0.483719354606953,-5.82635643220485,0.315968198315153,"LOC100130642","uncharacterized LOC100130642",TRUE
+"1562017_at",0.695744345349551,0.165487068431664,1.43417141238823,-4.98464149472759,1.11930925553286,"LOC100130654","uncharacterized LOC100130654",TRUE
+"231540_at",0.713633547141264,0.188559015993504,1.35663825738711,-5.08093799513741,0.516290721111993,"LOC100130691","uncharacterized LOC100130691",TRUE
+"236875_at",0.673190784310977,0.138801921393307,-1.53556871772393,-4.85215818256622,-1.1466640210738,"LOC100130705","uncharacterized LOC100130705",TRUE
+"215740_at",0.960588243569671,0.820883791759035,-0.22911161093677,-5.91414879142902,-0.129017088588451,"LOC100130741","uncharacterized LOC100130741",TRUE
+"236228_at",0.714820080026392,0.190616258086129,1.35009743539184,-5.08885820460285,1.10538790296011,"LOC100130744","uncharacterized LOC100130744",TRUE
+"1559753_at",0.938152911190962,0.725930689680427,-0.355021419335271,-5.87847970676445,-0.171314232677398,"LOC100130778","uncharacterized LOC100130778",TRUE
+"1564471_at",0.993225426079816,0.968496348936115,0.0399429444895556,-5.93890643120223,0.0362957695550472,"LOC100130815","uncharacterized LOC100130815",TRUE
+"1564240_at",0.959584210327095,0.817493271219043,0.23353092087148,-5.91315552365206,0.170694794200751,"LOC100130856///PSPN","uncharacterized LOC100130856///persephin",TRUE
+"1569496_s_at",0.629115001559902,0.100060064994328,1.71628761114565,-4.59856957411725,0.566934268466766,"LOC100130872","uncharacterized LOC100130872",TRUE
+"218638_s_at",0.653593944884398,0.122937109698537,1.60371826768202,-4.75909018803811,0.7384374381839,"LOC100130872///SPON2","uncharacterized LOC100130872///spondin 2",TRUE
+"230574_at",0.755868740464627,0.250429138548613,1.18021934557322,-5.28310337650405,0.632080583122026,"LOC100130938","uncharacterized LOC100130938",TRUE
+"1554666_at",0.592007267652348,0.0691172133064796,1.91033897023683,-4.30316911093824,1.29645826854433,"LOC100130950","uncharacterized LOC100130950",TRUE
+"233840_at",0.623852759019384,0.095458297551425,-1.74153517826652,-4.5614432546343,-1.11575194616461,"LOC100130950","uncharacterized LOC100130950",TRUE
+"238237_at",0.940778455596726,0.734956177056357,-0.342831894211153,-5.88259872239908,-0.298987449358551,"LOC100130964","ADAM metallopeptidase domain 3A-like",TRUE
+"235990_at",0.814439884224271,0.365381809326126,0.924115235877143,-5.53208271937426,0.371505357551396,"LOC100130987","uncharacterized LOC100130987",TRUE
+"1562022_s_at",0.904381089098038,0.607424474752042,-0.521161495137344,-5.80825149225573,-0.255476529171897,"LOC100130987///RAD9A","uncharacterized LOC100130987///RAD9 checkpoint clamp component A",TRUE
+"1558977_at",0.636147339487472,0.107423409250068,-1.67787358994742,-4.65427660195636,-1.49981361495926,"LOC100130992","uncharacterized LOC100130992",TRUE
+"244029_at",0.402463840838386,0.0146759364069139,2.64689564419198,-3.00460503906194,0.817641148462567,"LOC100131043","uncharacterized LOC100131043",TRUE
+"239546_at",0.983783029912313,0.920920427838832,-0.10041183834051,-5.9347738414717,-0.0923783038689798,"LOC100131053","uncharacterized LOC100131053",TRUE
+"1556145_a_at",0.980953956539862,0.91044368586402,-0.113771337877581,-5.93338094173182,-0.0577424749000301,"LOC100131170","uncharacterized LOC100131170",TRUE
+"241810_at",0.719412173140763,0.195400219101722,1.33509914065424,-5.10689835174332,0.602517543492031,"LOC100131180","uncharacterized LOC100131180",TRUE
+"1558152_at",0.716472449896956,0.192253068592222,1.34493290343531,-5.09508924253583,1.05105861190718,"LOC100131262","uncharacterized LOC100131262",TRUE
+"1563120_at",0.976371465776674,0.886963701829464,-0.143793053477829,-5.92961776311301,-0.1274561626042,"LOC100131270///LOC100129029","uncharacterized LOC100131270///uncharacterized LOC100129029",TRUE
+"236593_at",0.95018792835023,0.773648540475472,0.291144947206673,-5.89848151343999,0.0866491926106896,"LOC100131303","uncharacterized LOC100131303",TRUE
+"1564050_at",0.88060408451642,0.536032059479186,-0.628609150708201,-5.74903195825932,-0.545957017464385,"LOC100131347","RAD52 motif containing 1 pseudogene",TRUE
+"1558477_at",0.850536169066796,0.453311051675325,0.763342333825148,-5.65979250580837,0.521432391822175,"LOC100131496","uncharacterized LOC100131496",TRUE
+"224351_at",0.84571977676742,0.443323653694706,-0.780555683969734,-5.64721052594675,-0.599547430769484,"LOC100131508","PRO2122",TRUE
+"215421_at",0.990810941805126,0.95445199348237,-0.0577670591295958,-5.93805826564938,-0.0415173886156337,"LOC100131510","uncharacterized LOC100131510",TRUE
+"221186_at",0.94895689004559,0.769058163407926,-0.297232053062477,-5.896744339631,-0.216049251949371,"LOC100131532","uncharacterized LOC100131532",TRUE
+"1558569_at",0.870980161749509,0.511132578542205,0.66784051418629,-5.72475197982901,0.441647193560708,"LOC100131541","uncharacterized LOC100131541",TRUE
+"1560001_at",0.888462309966324,0.554575980146881,0.600027013856928,-5.76583013010918,0.245351872347217,"LOC100131581","uncharacterized LOC100131581",TRUE
+"1569832_at",0.954340987878543,0.789861570362175,0.269733426023893,-5.90430865496341,0.240452362245026,"LOC100131655","uncharacterized LOC100131655",TRUE
+"236973_at",0.978072252406502,0.893760851893953,-0.135089480514947,-5.93079889095612,-0.114141006744158,"LOC100131662","uncharacterized LOC100131662",TRUE
+"1564202_at",0.975398143273847,0.880917096813919,0.151545122698023,-5.92850381253326,0.104526651163116,"LOC100131756","uncharacterized LOC100131756",TRUE
+"1563822_at",0.708894565317004,0.181491916015237,-1.3795454935133,-5.05294841166055,-0.982465615117587,"LOC100131763","uncharacterized LOC100131763",TRUE
+"1559180_at",0.497871139123625,0.0309226931257685,-2.3047513973786,-3.63853205037319,-1.41215248313648,"LOC100131860","uncharacterized LOC100131860",TRUE
+"1564660_at",0.993516281527979,0.969629601130873,0.038505357038816,-5.93896135630254,0.023541483549387,"LOC100131864","uncharacterized LOC100131864",TRUE
+"1557669_at",0.871090069138449,0.51158120018355,0.667124456141587,-5.72520776923716,0.314263137122383,"LOC100132005","uncharacterized LOC100132005",TRUE
+"237173_at",0.789595899448337,0.316864496111647,1.02404658814394,-5.44142766178766,0.408590165418888,"LOC100132057","phosphodiesterase 4D interacting protein pseudogene",TRUE
+"230837_at",0.893950023919247,0.570116934321723,0.576456665790795,-5.77911458480555,0.305735865828749,"LOC100132057","phosphodiesterase 4D interacting protein pseudogene",TRUE
+"1559514_at",0.756006545489432,0.250826240815212,1.1792003208531,-5.28420053487617,0.482361320035722,"LOC100132077","uncharacterized LOC100132077",TRUE
+"1556844_at",0.762778023494851,0.262392849856263,1.15003142950235,-5.3152538633276,0.956712254119808,"LOC100132078","uncharacterized LOC100132078",TRUE
+"237794_at",0.980009054680439,0.905294119226459,-0.120345476018622,-5.93263179013185,-0.0469424824407234,"LOC100132154///LOC100132004///ANKRD30BL///ANKRD30BP2","ankyrin repeat domain 30B pseudogene///ankyrin repeat domain 30B pseudogene///ankyrin repeat domain 30B-like///ankyrin repeat domain 30B pseudogene 2",TRUE
+"224519_at",0.833184482935234,0.410537658887596,-0.838804665689671,-5.60267928990017,-0.239919067002261,"LOC100132167","uncharacterized LOC100132167",TRUE
+"243019_at",0.971216837324271,0.861901245251834,0.175988893645047,-5.92460936669654,0.0972211309253765,"LOC100132207","uncharacterized LOC100132207",TRUE
+"236758_at",0.748062459902618,0.239940948501367,1.20758233532519,-5.25333381890307,0.45517448752073,"LOC100132304///LINC00684","long intergenic non-protein coding RNA 684///long intergenic non-protein coding RNA 684",TRUE
+"224526_at",0.983935461205724,0.921395594031233,-0.0998063887790615,-5.93483285574938,-0.059123188339802,"LOC100132319","uncharacterized LOC100132319",TRUE
+"1558310_s_at",0.917887697142565,0.651236542128918,-0.458248766267674,-5.83791849815113,-0.219164949852941,"LOC100132356","uncharacterized LOC100132356",TRUE
+"224103_at",0.90466378569832,0.608836980854031,0.519100985138674,-5.80928204949882,0.158850915846888,"LOC100132661","PRO0419",TRUE
+"1555180_at",0.936992192746977,0.718905001292479,0.364548078553169,-5.87516155721418,0.227948437083894,"LOC100132686","uncharacterized LOC100132686",TRUE
+"1557601_s_at",0.963379172403332,0.83309479607509,0.213233317927638,-5.91756170981732,0.102847176469262,"LOC100132731///KIAA1257","uncharacterized LOC100132731///KIAA1257",TRUE
+"1557161_at",0.937113154905832,0.720273018442203,0.362690412182657,-5.87581539477065,0.346338435722489,"LOC100132735","uncharacterized LOC100132735",TRUE
+"1560141_at",0.778580821633075,0.298798611962552,1.06397521718958,-5.40285382818853,0.567369930967306,"LOC100133039","uncharacterized LOC100133039",TRUE
+"1558784_at",0.968066640321622,0.849706973076388,-0.191720912984243,-5.92179638711997,-0.131682418846977,"LOC100133089","uncharacterized LOC100133089",TRUE
+"1570411_at",0.903458828743485,0.604569696703025,0.525332933184313,-5.80615298810603,0.444471579640085,"LOC100133131","uncharacterized LOC100133131",TRUE
+"232586_x_at",0.904832003218088,0.61021056054964,0.517099439743883,-5.81027930699977,0.260154944135343,"LOC100133315","transient receptor potential cation channel, subfamily C, member 2-like",TRUE
+"1560911_at",0.931582451098271,0.697574924979856,0.393687316412199,-5.86447436524684,0.224308815664473,"LOC100133461","uncharacterized LOC100133461",TRUE
+"1561850_at",0.873330973137109,0.518482372212749,0.656153013529553,-5.73213276927427,0.2757800215648,"LOC100133669","uncharacterized LOC100133669",TRUE
+"1564280_x_at",0.958264429662518,0.811234154391574,-0.241701827836259,-5.91126935266162,-0.226003833405168,"LOC100133920","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene",TRUE
+"230325_at",0.875187315707138,0.522232882271558,-0.650224344751476,-5.7358290059133,-0.38291980621419,"LOC100133985","uncharacterized LOC100133985",TRUE
+"233342_at",0.986736327611135,0.938172285516502,-0.0784525511978303,-5.93668614780617,-0.0356491345909014,"LOC100134040","uncharacterized LOC100134040",TRUE
+"230552_at",0.839519981963042,0.427045252401888,0.809128187632106,-5.62574261855281,0.884007696029506,"LOC100134317///LOC284412","uncharacterized LOC100134317///uncharacterized LOC284412",TRUE
+"1569270_at",0.769487370840268,0.276976003107487,-1.1145773008767,-5.35207566547415,-0.946626606041839,"LOC100134368","uncharacterized LOC100134368",TRUE
+"236841_at",0.972405051071295,0.866863991260193,0.169599599041662,-5.92568328840693,0.0903355313195782,"LOC100134445","uncharacterized LOC100134445",TRUE
+"231886_at",0.641880516735663,0.11214307987212,1.65440893266692,-4.68783440512412,0.763700416759597,"LOC100134822","uncharacterized LOC100134822",TRUE
+"229685_at",0.984798640722849,0.925312139215275,0.0948174202587838,-5.93530556453444,0.0439019847197386,"LOC100134937","uncharacterized LOC100134937",TRUE
+"240185_at",0.818852235468236,0.372652167672612,0.909930235525847,-5.54425935746949,0.36250108697222,"LOC100147773","uncharacterized LOC100147773",TRUE
+"235060_at",0.841505765950996,0.432565515355332,0.799364597837273,-5.63316009777983,0.356990295226726,"LOC100190986","uncharacterized LOC100190986",TRUE
+"235167_at",0.878606937652997,0.53154081300717,0.635610760032363,-5.744802237316,0.299275341942135,"LOC100190986","uncharacterized LOC100190986",TRUE
+"229748_x_at",0.93970337526296,0.729556998137396,0.35011736157885,-5.88015395602776,0.244338127431252,"LOC100233156///TEKT4P2///MAFIP","tektin 4 pseudogene///tektin 4 pseudogene 2///MAFF interacting protein (pseudogene)",TRUE
+"227330_x_at",0.957430653957785,0.80776810028633,0.246233767204818,-5.91019539441493,0.147964652806804,"LOC100233156///TEKT4P2///MAFIP","tektin 4 pseudogene///tektin 4 pseudogene 2///MAFF interacting protein (pseudogene)",TRUE
+"227715_at",0.998047179825832,0.99128433642169,0.0110476066211302,-5.93962403505782,0.00713019244163071,"LOC100233156///TEKT4P2///MAFIP","tektin 4 pseudogene///tektin 4 pseudogene 2///MAFF interacting protein (pseudogene)",TRUE
+"1557493_x_at",0.914588178928864,0.640336113876257,0.473717152341026,-5.83096978201625,0.294408030876264,"LOC100240728","uncharacterized LOC100240728",TRUE
+"1557491_at",0.934612165247339,0.709703267023442,0.377077761268277,-5.8706654210184,0.216292475491414,"LOC100240728","uncharacterized LOC100240728",TRUE
+"239612_at",0.879419229950485,0.533683219931543,0.632266895247923,-5.74682791247754,0.219469138783871,"LOC100240734","uncharacterized LOC100240734",TRUE
+"233491_at",0.816966928109267,0.369263049762207,0.916519545347849,-5.53862457847154,0.699078845532095,"LOC100268168","uncharacterized LOC100268168",TRUE
+"229722_at",0.899808883319249,0.593333744368628,0.541844033766805,-5.79768710653578,0.173881214474211,"LOC100270804","uncharacterized LOC100270804",TRUE
+"1556999_at",0.9181984176728,0.652727812484106,0.456141444416038,-5.83884766022872,0.250924166809088,"LOC100271832","uncharacterized LOC100271832",TRUE
+"213089_at",0.643082025527735,0.113639510423505,1.64714310587832,-4.69815247854377,0.616489447024989,"LOC100272216","uncharacterized LOC100272216",TRUE
+"243785_at",0.746504348740603,0.238157756837354,-1.21232354205281,-5.24811538678065,-0.816826040103555,"LOC100272217","uncharacterized LOC100272217",TRUE
+"243784_s_at",0.79782885150643,0.331582488716068,-0.992682891248207,-5.47079179060466,-0.973660023482894,"LOC100272217","uncharacterized LOC100272217",TRUE
+"230953_at",0.94632739401154,0.757390254753533,-0.312756725095328,-5.89215251878208,-0.187923933835253,"LOC100286922","DnaJ heat shock protein family (Hsp40) member B3 pseudogene",TRUE
+"240115_at",0.771159692311272,0.280316879578206,-1.10664799115191,-5.36017119914053,-0.693490106018642,"LOC100286925","uncharacterized LOC100286925",TRUE
+"1556301_at",0.85737998591191,0.472731176137182,-0.730512806161503,-5.68305256225591,-0.281702296515741,"LOC100287015","uncharacterized LOC100287015",TRUE
+"233174_at",0.992490513431419,0.965018498297583,-0.0443553251487438,-5.93872528067601,-0.0403243885684486,"LOC100287015","uncharacterized LOC100287015",TRUE
+"1555206_at",0.800949838870793,0.336904332772757,0.981579899394684,-5.48098808390049,0.257132839496268,"LOC100287210","uncharacterized LOC100287210",TRUE
+"1557027_at",0.66071672549246,0.128699279862729,1.57816502971375,-4.7943579738597,1.33041692360889,"LOC100287221","uncharacterized LOC100287221",TRUE
+"1565608_at",0.470295441559609,0.0252458549790115,2.39968999128412,-3.4673768947513,1.04260766548166,"LOC100287290","cytokine receptor CRL2",TRUE
+"240936_at",0.534211007350826,0.0423440068136671,2.15435821676053,-3.90126337823231,1.33926045534379,"LOC100287290","cytokine receptor CRL2",TRUE
+"1565610_at",0.83030603167465,0.402450822044165,0.853618881392882,-5.59087592914825,0.307728957203699,"LOC100287290","cytokine receptor CRL2",TRUE
+"217220_at",0.957571530817866,0.809248448768567,-0.244297540819944,-5.91065665941255,-0.281626440095348,"LOC100287387","uncharacterized LOC100287387",TRUE
+"227794_at",0.612420348961838,0.0841350275578842,-1.80841619757891,-4.46117151157161,-1.18543211004209,"LOC100287413///GLYATL1","uncharacterized LOC100287413///glycine-N-acyltransferase like 1",TRUE
+"227695_at",0.839425347843955,0.425261895856346,0.812299142477658,-5.62331543336584,0.305617491565938,"LOC100287413///GLYATL1","uncharacterized LOC100287413///glycine-N-acyltransferase like 1",TRUE
+"234759_at",0.629618998226163,0.100514709409924,1.71384730447812,-4.60213658846014,0.822324990313765,"LOC100287497","septin 7 pseudogene",TRUE
+"230606_at",0.637812558837132,0.10913514227266,-1.66926457473762,-4.66663043898891,-1.49954246721581,"LOC100287525","uncharacterized LOC100287525",TRUE
+"1558118_at",0.774230543658252,0.287371832339882,1.09012613597362,-5.37687434549789,0.815234694810127,"LOC100287576///DGCR5","uncharacterized LOC100287576///DiGeorge syndrome critical region gene 5 (non-protein coding)",TRUE
+"214871_x_at",0.714896297822116,0.190691314264979,-1.34985985361446,-5.08914528711301,-0.530143065704798,"LOC100287590","uncharacterized LOC100287590",TRUE
+"240483_at",0.918409982899324,0.653741768105589,0.454709815959266,-5.83947650049556,0.376100376485516,"LOC100287610///ZNF717","zinc finger protein 717-like///zinc finger protein 717",TRUE
+"240999_at",0.871451481476429,0.512826532941517,0.665138577926269,-5.72646938096786,0.42103568182599,"LOC100287704","uncharacterized LOC100287704",TRUE
+"230583_s_at",0.746535697909741,0.238386722025551,1.21171326734471,-5.2487880826421,0.870747627328171,"LOC100287728///ZNF75D","uncharacterized LOC100287728///zinc finger protein 75D",TRUE
+"230584_at",0.831013183269159,0.404941824041103,-0.849035542618183,-5.59454833784805,-0.59706742647662,"LOC100287728///ZNF75D","uncharacterized LOC100287728///zinc finger protein 75D",TRUE
+"240752_at",0.782876787164404,0.305300134820909,1.04941376379216,-5.41707486212603,0.716882844982743,"LOC100287808","uncharacterized LOC100287808",TRUE
+"243083_at",0.955730092376044,0.797315977885872,0.259932536612875,-5.90682857263106,0.0887569282955916,"LOC100287834///LOC100287704","uncharacterized LOC100287834///uncharacterized LOC100287704",TRUE
+"215947_s_at",0.94333312187812,0.74559864399646,-0.328526101408308,-5.88725133851863,-0.147194586868576,"LOC100287852///FAM136A","protein FAM136A pseudogene///family with sequence similarity 136 member A",TRUE
+"1563008_at",0.892878124464201,0.566379499088568,-0.582094551460425,-5.77598388099388,-0.306946640268602,"LOC100287877","uncharacterized LOC100287877",TRUE
+"1554609_at",0.830635993561085,0.404095139376317,-0.850591377747093,-5.59330378855578,-0.340360069934405,"LOC100287896","uncharacterized LOC100287896",TRUE
+"230940_at",0.945272089973488,0.752994509184895,-0.318625652481934,-5.8903563195505,-0.302268397309972,"LOC100288123","uncharacterized LOC100288123",TRUE
+"226125_at",0.76912869907427,0.275092142920958,-1.11907923751025,-5.34745655758896,-0.715657844999763,"LOC100288152","uncharacterized LOC100288152",TRUE
+"234890_at",0.964281073574005,0.835802304568898,-0.209720400109936,-5.91828383211929,-0.104096649648521,"LOC100288175","uncharacterized LOC100288175",TRUE
+"230910_s_at",0.980009054680439,0.905644915969258,0.119897466060716,-5.93268417690062,0.0892021801443246,"LOC100288181","uncharacterized LOC100288181",TRUE
+"1562880_at",0.833125357773815,0.410353285502494,0.839140337344953,-5.60241397641443,0.622318411933185,"LOC100288238","uncharacterized LOC100288238",TRUE
+"1556444_a_at",0.468732760220321,0.0247486812035011,2.40891947114254,-3.45053189502757,1.52409411553605,"LOC100288310","uncharacterized LOC100288310",TRUE
+"1556724_at",0.76524135343539,0.265371959747979,-1.14267321249112,-5.3229795326382,-1.00202643806969,"LOC100288490","uncharacterized LOC100288490",TRUE
+"1556725_a_at",0.969891556938326,0.857413078736474,-0.181773646780897,-5.92360290924582,-0.0907894893872259,"LOC100288490","uncharacterized LOC100288490",TRUE
+"215247_at",0.966641191718519,0.844936598692511,0.197888520169331,-5.92062813252853,0.0570124114786497,"LOC100288570","glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) pseudogene",TRUE
+"1569790_at",0.525405708458677,0.0393315015793526,2.19005430175525,-3.83988035585351,1.10809485133886,"LOC100288590","cutaneous T-cell lymphoma-associated antigen 1 pseudogene",TRUE
+"1558750_a_at",0.942427328086864,0.741289980278073,0.334309291801644,-5.88539411396605,0.157111830624721,"LOC100288637///ARHGAP11B","OTU deubiquitinase 7A pseudogene///Rho GTPase activating protein 11B",TRUE
+"234344_at",0.671298718565642,0.137068168545048,-1.5426927047329,-4.84257839958401,-0.70420049040604,"LOC100288675","uncharacterized LOC100288675",TRUE
+"1569971_at",0.976371465776674,0.887213929005334,-0.143472446608872,-5.92966257671895,-0.123502459029698,"LOC100288721","uncharacterized LOC100288721",TRUE
+"1559817_at",0.904807245926266,0.609327897485233,-0.518385387718791,-5.80963902259696,-0.362496319168633,"LOC100288798","uncharacterized LOC100288798",TRUE
+"239127_at",0.73759219552868,0.22413640252202,-1.25057293779088,-5.20537056022618,-0.673105144387205,"LOC100288860","uncharacterized LOC100288860",TRUE
+"229556_at",0.93089781226267,0.693945723822267,0.398679221672007,-5.86256229925613,0.318707628905135,"LOC100288893","uncharacterized LOC100288893",TRUE
+"236657_at",0.70939075283402,0.182339925313895,1.37675988930081,-5.05637286930396,1.50484291099646,"LOC100288911","uncharacterized LOC100288911",TRUE
+"236656_s_at",0.768852835478002,0.273547162593047,1.12278815489062,-5.34363872559249,1.18997066868964,"LOC100288911","uncharacterized LOC100288911",TRUE
+"1553474_at",0.823074246722209,0.389682453201525,0.877403362345701,-5.57152321330362,0.927997620171808,"LOC100288966","POTE ankyrin domain family member D-like",TRUE
+"1564749_at",0.820288124919738,0.378594653441489,0.898471590096747,-5.55396867525435,0.417278836643664,"LOC100289045","uncharacterized LOC100289045",TRUE
+"1563077_at",0.896159990898752,0.579012312824758,-0.563113153986715,-5.7864065728466,-0.19032209274993,"LOC100289058","uncharacterized LOC100289058",TRUE
+"1563071_at",0.97070558355376,0.860444292047824,0.177866062687064,-5.92428632463129,0.0781156639477487,"LOC100289061","uncharacterized LOC100289061",TRUE
+"1556839_s_at",0.48580305784244,0.0283926488380153,2.34489275370894,-3.56664408347437,0.801719241188377,"LOC100289090","uncharacterized LOC100289090",TRUE
+"1563079_at",0.609431573469723,0.0816365220684454,1.82421310118082,-4.43708762480358,1.1197035230262,"LOC100289090","uncharacterized LOC100289090",TRUE
+"1559877_at",0.776983560547865,0.296085093443343,1.07011950102137,-5.39680050983711,0.670061560516863,"LOC100289094","uncharacterized LOC100289094",TRUE
+"238456_at",0.941106542715586,0.735905792926624,-0.341552480266775,-5.88302280589271,-0.173560268388124,"LOC100289230","uncharacterized LOC100289230",TRUE
+"228798_x_at",0.872668627020452,0.516779840352227,-0.658852123822319,-5.73043934447289,-0.291454569494998,"LOC100289283","uncharacterized LOC100289283",TRUE
+"233775_x_at",0.76912869907427,0.274786853558165,-1.11981091491097,-5.3467042793256,-0.368492476067464,"LOC100289333","uncharacterized LOC100289333",TRUE
+"229338_at",0.567292616148537,0.0573266858421348,-2.00503850748398,-4.15100504004958,-0.798376360861146,"LOC100289361","uncharacterized LOC100289361",TRUE
+"217376_at",0.722192678020526,0.198546063041931,-1.32539270968621,-5.11848310468028,-1.14547565209474,"LOC100289473","cytoskeleton associated protein 2-like pseudogene",TRUE
+"239215_at",0.716245563733659,0.192000629612458,1.34572714932377,-5.09413228185517,0.966962347551623,"LOC100289495","uncharacterized LOC100289495",TRUE
+"216794_at",0.419319894485853,0.0173019786366728,2.57280720226309,-3.14572090933396,1.55330856034306,"LOC100289518","immunoglobin superfamily member 21 pseudogene",TRUE
+"216793_x_at",0.954449231029359,0.791106177444691,-0.268095192522374,-5.90473630994094,-0.217483384225192,"LOC100289518","immunoglobin superfamily member 21 pseudogene",TRUE
+"1564639_at",0.896118635245982,0.57831366562472,-0.564157398697359,-5.78584188277965,-0.297380335799196,"LOC100291323","uncharacterized LOC100291323",TRUE
+"233831_at",0.686162889425718,0.154915312429283,1.47262853815917,-4.93525375655623,0.903750168820509,"LOC100291666","serologically defined breast cancer antigen NY-BR-40",TRUE
+"217320_at",0.910165867297668,0.62652319643631,-0.493489027404577,-5.82175937626643,-0.410952306711299,"LOC100293211","uncharacterized LOC100293211",TRUE
+"217384_x_at",0.94632739401154,0.757376504076752,0.312775066572654,-5.89214695685213,0.242061135152433,"LOC100293211","uncharacterized LOC100293211",TRUE
+"215721_at",0.818598510248558,0.37195139991047,0.911289437645862,-5.54310012045861,0.430798650871843,"LOC100293211///IGHG1","uncharacterized LOC100293211///immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"234419_x_at",0.725276957219979,0.204126809965001,-1.30846501811436,-5.13851589847713,-0.560388472040912,"LOC100293211///IGHV4-31///IGHM///IGHG3///IGHG1///IGHA1","uncharacterized LOC100293211///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"204403_x_at",0.224900164818508,0.00277243184431046,-3.36546020154486,-1.55429135862893,-1.39118592957436,"LOC100294033///TCAF1","protein FAM115A-like///TRPM8 channel associated factor 1",TRUE
+"212981_s_at",0.26392932766945,0.00399422403787422,-3.21177628338998,-1.87447953774089,-1.4580089143004,"LOC100294033///TCAF1","protein FAM115A-like///TRPM8 channel associated factor 1",TRUE
+"210529_s_at",0.42796179417767,0.0185279536205785,-2.54176977013627,-3.20424479853141,-1.02336805806186,"LOC100294033///TCAF1","protein FAM115A-like///TRPM8 channel associated factor 1",TRUE
+"212979_s_at",0.497725944448536,0.0307863597069668,-2.30683618101761,-3.63481612468069,-1.27034431347348,"LOC100294033///TCAF1","protein FAM115A-like///TRPM8 channel associated factor 1",TRUE
+"214809_at",0.842397669245069,0.436264021448604,0.792866210220311,-5.63805005185534,0.519207344710679,"LOC100294145","uncharacterized LOC100294145",TRUE
+"1569078_at",0.98539961718117,0.928658945331073,0.0905561537376033,-5.93569014913129,0.0866751133327543,"LOC100294362","uncharacterized LOC100294362",TRUE
+"1556242_a_at",0.499265335405817,0.0314397905770869,2.29691988687741,-3.65247349087725,1.25224039026155,"LOC100310756","uncharacterized LOC100310756",TRUE
+"222947_at",0.671498069723584,0.137632766954771,1.5403646613789,-4.84571283517426,1.20737957186827,"LOC100379224","uncharacterized LOC100379224",TRUE
+"1570064_at",0.931398124704888,0.696795993220055,0.394757861817186,-5.86406630963235,0.269735792311277,"LOC100419741","zinc finger protein 772 pseudogene",TRUE
+"217205_at",0.774447611376107,0.290815080750859,-1.0821686452199,-5.38483928956513,-0.295414035008097,"LOC100420758","poly(A) binding protein nuclear 1 pseudogene",TRUE
+"1561665_at",0.901788521024914,0.599348238504249,-0.532987146769937,-5.8022600654736,-0.397427021362054,"LOC100421171","thyroid hormone receptor interactor 11 pseudogene",TRUE
+"233074_at",0.927016202006999,0.681253058923479,0.416220140881019,-5.8556554965217,0.302227694067141,"LOC100421494","microtubule affinity regulating kinase 2 pseudogene",TRUE
+"1568897_at",0.93032716386748,0.69186750186136,0.401542421756975,-5.86145489174572,0.330768131768833,"LOC100422212","eukaryotic translation initiation factor 3 subunit J pseudogene",TRUE
+"243581_at",0.493519901382617,0.0298884868408089,2.32078169852589,-3.60990956952163,2.11113894736558,"LOC100422526","proteasome activator subunit 3 pseudogene",TRUE
+"237888_at",0.389015468142133,0.0129330292739226,2.70330959896978,-2.89587383833259,0.939966127864297,"LOC100422737","uncharacterized LOC100422737",TRUE
+"230432_at",0.603702127972549,0.0782560693030047,1.84626723626015,-4.40321280084514,1.07606910353111,"LOC100422737","uncharacterized LOC100422737",TRUE
+"237889_s_at",0.819018525257656,0.373357936615644,0.908563042808079,-5.54542379841637,0.479544384331423,"LOC100422737","uncharacterized LOC100422737",TRUE
+"235774_at",0.940044918888428,0.731266455762119,0.347808606511799,-5.88093419913415,0.21573614414382,"LOC100422737","uncharacterized LOC100422737",TRUE
+"1561304_a_at",0.877973353363219,0.5297226333927,0.638454303575051,-5.74307156705285,0.368503457106829,"LOC100422781","uncharacterized LOC100422781",TRUE
+"231637_at",0.975398143273847,0.882121653716986,0.150000073577487,-5.9287304879017,0.0826476682817985,"LOC100499194","uncharacterized LOC100499194",TRUE
+"235323_at",0.839519981963042,0.426685020577338,0.809768043209215,-5.62525356305706,0.594184983231655,"LOC100499489","uncharacterized LOC100499489",TRUE
+"228207_at",0.937623890519979,0.723508093489486,-0.358302573754822,-5.87734667242167,-0.443518231351688,"LOC100499489","uncharacterized LOC100499489",TRUE
+"231203_at",0.699391325858549,0.170867639796215,-1.41535335173422,-5.00841897190046,-0.461988290810472,"LOC100505478","uncharacterized LOC100505478",TRUE
+"216877_at",0.75983954487123,0.257643627295249,1.16189034839791,-5.30271105540638,0.471114308786062,"LOC100505498","uncharacterized LOC100505498",TRUE
+"216874_at",0.9116561917482,0.630432969594601,0.487872635243291,-5.82441310963154,0.250765554915318,"LOC100505498","uncharacterized LOC100505498",TRUE
+"231337_at",0.85334340854827,0.461174752300298,0.749949670079895,-5.66939829546792,0.500309154554968,"LOC100505498///TEX41","uncharacterized LOC100505498///testis expressed 41 (non-protein coding)",TRUE
+"235171_at",0.776743077119289,0.294274459980776,1.07424179455437,-5.39272176744452,1.55902588083535,"LOC100505501","uncharacterized LOC100505501",TRUE
+"231333_at",0.952644489493803,0.783135631126975,0.278599737493798,-5.90194925590928,0.103733975559214,"LOC100505515","uncharacterized LOC100505515",TRUE
+"242095_at",0.819807973515613,0.377883869200557,0.899835890935827,-5.55281861816594,0.345621291399659,"LOC100505530","uncharacterized LOC100505530",TRUE
+"215981_at",0.931582451098271,0.698183837331919,-0.392850767721743,-5.86479246941679,-0.195937820065238,"LOC100505534","uncharacterized LOC100505534",TRUE
+"241534_at",0.86395116513843,0.490370306497319,-0.701375776385059,-5.70288248255234,-0.42443853209363,"LOC100505549","uncharacterized LOC100505549",TRUE
+"238055_at",0.94895689004559,0.769436350469834,0.296730124708604,-5.89688893121403,0.10840363361913,"LOC100505549","uncharacterized LOC100505549",TRUE
+"231419_at",0.766353407604609,0.266634116728941,1.13957410457875,-5.32622033279169,0.472190304082797,"LOC100505555///ZNF846","uncharacterized LOC100505555///zinc finger protein 846",TRUE
+"1569156_at",0.865345395265289,0.495146545880045,-0.693590810831447,-5.70805052118065,-0.50240102944085,"LOC100505555///ZNF846","uncharacterized LOC100505555///zinc finger protein 846",TRUE
+"1569157_s_at",0.895457620469779,0.574048123007766,-0.570546791106746,-5.78236464087516,-0.315720742618498,"LOC100505555///ZNF846","uncharacterized LOC100505555///zinc finger protein 846",TRUE
+"1564331_at",0.93063506669027,0.692950785551488,0.400049539613504,-5.86203327135184,0.316582135280287,"LOC100505555///ZNF846","uncharacterized LOC100505555///zinc finger protein 846",TRUE
+"238376_at",0.827060995001753,0.395815005893476,-0.865918052032813,-5.58093021458756,-0.433011236236814,"LOC100505564","uncharacterized LOC100505564",TRUE
+"242841_at",0.77484479354461,0.291273617589801,1.08111407113218,-5.38589094453661,0.455997829084114,"LOC100505570","uncharacterized LOC100505570",TRUE
+"203055_s_at",0.777655491001604,0.296639833933781,1.0688601268342,-5.39804378128041,0.298901318350625,"LOC100505585///ARHGEF1","uncharacterized LOC100505585///Rho guanine nucleotide exchange factor 1",TRUE
+"1558497_a_at",0.927973182663162,0.683884066305365,-0.412573415567517,-5.85711549698933,-0.293386232324724,"LOC100505609","uncharacterized LOC100505609",TRUE
+"1558496_at",0.956619372543067,0.803040413815089,-0.252423847266279,-5.90869645451967,-0.210459346926777,"LOC100505609","uncharacterized LOC100505609",TRUE
+"243961_at",0.95952608973576,0.817141760352586,0.233989361699295,-5.91305140549161,0.177252382348597,"LOC100505622","uncharacterized LOC100505622",TRUE
+"1561979_at",0.769782310234542,0.27731014147947,1.11378112827334,-5.3528908430512,0.72623657602527,"LOC100505635","uncharacterized LOC100505635",TRUE
+"1557865_at",0.901788521024914,0.599278268110107,0.533089935512459,-5.80220741437944,0.358051661472564,"LOC100505658","uncharacterized LOC100505658",TRUE
+"231089_at",0.944963505981344,0.752308060226874,0.319543182955109,-5.890072518054,0.126844690970025,"LOC100505664","uncharacterized LOC100505664",TRUE
+"235886_at",0.973071267819624,0.869643434861034,-0.166024372256883,-5.92626693859247,-0.075447725131176,"LOC100505666","uncharacterized LOC100505666",TRUE
+"237758_at",0.865345395265289,0.495100776079813,0.693665208267814,-5.70800139306032,0.440226491155309,"LOC100505685","uncharacterized LOC100505685",TRUE
+"237270_at",0.966593471043185,0.844769971727097,0.198104092422391,-5.92058663279856,0.0871018457262789,"LOC100505710","uncharacterized LOC100505710",TRUE
+"237779_at",0.869903315953494,0.507718056065697,-0.673302086111612,-5.72126014497015,-0.279655223373803,"LOC100505711","uncharacterized LOC100505711",TRUE
+"238944_at",0.93523910610914,0.711866681068746,0.374126457700851,-5.87173795931744,0.367966169447299,"LOC100505715","uncharacterized LOC100505715",TRUE
+"1561370_at",0.980009054680439,0.905842765525188,-0.119644799289214,-5.9327136357208,-0.0976478250280826,"LOC100505716","uncharacterized LOC100505716",TRUE
+"1556166_x_at",0.595927404748624,0.072303385137507,1.88720242887008,-4.33957190813787,0.912816306329018,"LOC100505727","uncharacterized LOC100505727",TRUE
+"1556165_at",0.907964244160782,0.61760708080049,0.506357839987979,-5.81556707075132,0.194839153812312,"LOC100505727","uncharacterized LOC100505727",TRUE
+"231036_at",0.989466327245298,0.947878881063136,0.066115426299477,-5.93755463049507,0.038939200519251,"LOC100505774","uncharacterized LOC100505774",TRUE
+"1557068_at",0.983498417373669,0.919353508709031,-0.102408656718479,-5.93457668074342,-0.0600243548662545,"LOC100505782","uncharacterized LOC100505782",TRUE
+"239514_at",0.751464513744428,0.244547400349331,-1.19545613218412,-5.26659978016307,-0.925972353673931,"LOC100505784","uncharacterized LOC100505784",TRUE
+"243742_at",0.722442821599878,0.199079088704041,1.32376000518799,-5.12042476604236,0.780552246160526,"LOC100505797","myosin heavy chain IB-like",TRUE
+"237552_at",0.0533112880354026,8.19048595331289e-05,4.81082071957646,1.54712052818438,5.56276663563647,"LOC100505817","uncharacterized LOC100505817",TRUE
+"231563_at",0.643852971767472,0.114763999357833,-1.64173602448264,-4.70580841841955,-1.09785318941624,"LOC100505824","uncharacterized LOC100505824",TRUE
+"231434_at",0.98539961718117,0.92769224055658,-0.0917868148918857,-5.93558089476682,-0.0318272921652927,"LOC100505841","zinc finger protein 474-like",TRUE
+"1568648_a_at",0.903021267024792,0.602859462474661,-0.527836471896192,-5.8048857237498,-0.358491603220729,"LOC100505851","uncharacterized LOC100505851",TRUE
+"1568647_at",0.913123070637484,0.635079342210868,0.481218729704124,-5.82751864195803,0.312740439145517,"LOC100505851","uncharacterized LOC100505851",TRUE
+"1556909_at",0.70939075283402,0.182362180836103,-1.37668692110703,-5.05646249482232,-1.00809015753356,"LOC100505853","uncharacterized LOC100505853",TRUE
+"234082_at",0.79943091106207,0.334167733562952,0.987274063146316,-5.47577195369531,1.00292744349284,"LOC100505874","uncharacterized LOC100505874",TRUE
+"216828_at",0.902229953331547,0.600837860211508,0.530800220767982,-5.80337792530533,0.330970591600039,"LOC100505874///MLLT10P1","uncharacterized LOC100505874///myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 pseudogene 1",TRUE
+"1557424_at",0.902770867950228,0.602206683932,-0.528792946753677,-5.80440001804763,-0.388749410668458,"LOC100505878","uncharacterized LOC100505878",TRUE
+"244668_at",0.719965488428987,0.195744937584493,1.33402957782227,-5.10817837372822,0.777748497700689,"LOC100505902","uncharacterized LOC100505902",TRUE
+"1557004_at",0.805335305758344,0.344686166223332,0.965559400927601,-5.49551604224174,0.627878404011969,"LOC100505902///LOC285389","uncharacterized LOC100505902///uncharacterized LOC285389",TRUE
+"237200_at",0.995366465678067,0.978271675822815,-0.0275449593616336,-5.93931394063645,-0.0196792116934477,"LOC100505902///LOC285389","uncharacterized LOC100505902///uncharacterized LOC285389",TRUE
+"239174_at",0.565210521362331,0.0564663885202949,-2.01260582246012,-4.1386315223187,-0.867732134970834,"LOC100505912","uncharacterized LOC100505912",TRUE
+"81737_at",0.959451355429682,0.816893942107689,0.234312597316361,-5.91297787218311,0.118780997202719,"LOC100505915","uncharacterized LOC100505915",TRUE
+"1559522_at",0.761311110432845,0.260454034213925,1.15485336334841,-5.31016748701774,0.402208257766612,"LOC100505918","uncharacterized LOC100505918",TRUE
+"240100_at",0.897949253801113,0.585657939317146,0.553211502846965,-5.79171058087613,0.416095641847047,"LOC100505920","uncharacterized LOC100505920",TRUE
+"230641_at",0.830209851097162,0.401993152225812,-0.854462948534302,-5.59019760961201,-1.26649322342555,"LOC100505938","uncharacterized LOC100505938",TRUE
+"230548_at",0.754097406036437,0.247421186408553,-1.18797766171551,-5.27472307965796,-0.933307049100084,"LOC100505942","uncharacterized LOC100505942",TRUE
+"237260_at",0.970135831114343,0.858249189273723,0.180695517038967,-5.92379294716627,0.11166912331019,"LOC100505978","uncharacterized LOC100505978",TRUE
+"226535_at",0.590910793348582,0.0684601122880816,1.91522657470141,-4.29543949985621,3.08209039941828,"LOC100505984///ITGB6","uncharacterized LOC100505984///integrin subunit beta 6",TRUE
+"208083_s_at",0.596382916302699,0.0727679693510935,1.88390373132354,-4.34473674876602,2.78209791993057,"LOC100505984///ITGB6","uncharacterized LOC100505984///integrin subunit beta 6",TRUE
+"208084_at",0.604824625238112,0.0788459702925793,1.8423598621303,-4.4092356774146,2.66524835474199,"LOC100505984///ITGB6","uncharacterized LOC100505984///integrin subunit beta 6",TRUE
+"239517_at",0.692573415624882,0.162094346576156,-1.44629145273344,-4.96919136940621,-0.50318390289091,"LOC100505984///ITGB6","uncharacterized LOC100505984///integrin subunit beta 6",TRUE
+"231483_at",0.910165867297668,0.626417528007758,0.493641042938036,-5.82168713681083,0.256195286178943,"LOC100505985","uncharacterized LOC100505985",TRUE
+"1556289_at",0.87927534655779,0.533247268789836,0.63294673786837,-5.746416904004,0.516707883949785,"LOC100506016","uncharacterized LOC100506016",TRUE
+"230431_at",0.962741248200658,0.830443110503551,0.216676469057301,-5.91684233976367,0.140020152545574,"LOC100506022","uncharacterized LOC100506022",TRUE
+"241504_at",0.917887697142565,0.651244011573913,0.458238205912532,-5.83792316489502,0.237006323266121,"LOC100506047","uncharacterized LOC100506047",TRUE
+"1560038_at",0.870980161749509,0.511180579217953,0.667763882156335,-5.72480078047067,0.523586391383827,"LOC100506071","uncharacterized LOC100506071",TRUE
+"231028_at",0.827866702343255,0.39727632742233,-0.863198231295099,-5.58314099818367,-0.825172486629135,"LOC100506082","uncharacterized LOC100506082",TRUE
+"1568787_at",0.948429371744093,0.764929644097498,0.302716511809723,-5.89514863366509,0.216649566593105,"LOC100506083","uncharacterized LOC100506083",TRUE
+"227985_at",0.671298718565642,0.137393754736314,1.54134923278014,-4.84438768339316,1.17944351672941,"LOC100506098","uncharacterized LOC100506098",TRUE
+"228773_at",0.685154158710982,0.153676239328707,1.47727385671484,-4.9292164234482,0.847413553563587,"LOC100506100","uncharacterized LOC100506100",TRUE
+"1557214_at",0.978240571220736,0.894448348061557,-0.134209765906332,-5.93091417861513,-0.082946569286459,"LOC100506107","uncharacterized LOC100506107",TRUE
+"237090_at",0.972112264314695,0.866116185913541,0.170561893161921,-5.92552407740504,0.0520295844705458,"LOC100506113","uncharacterized LOC100506113",TRUE
+"235379_at",0.614034563169767,0.0849885313160868,1.80311283702179,-4.46922306078707,1.35287601419661,"LOC100506114","uncharacterized LOC100506114",TRUE
+"1561228_at",0.859465912277024,0.476681372927966,-0.723933355253705,-5.68759746300509,-0.441652930142852,"LOC100506122","uncharacterized LOC100506122",TRUE
+"221973_at",0.997569006069999,0.987698227244505,-0.0155935359245303,-5.93956504796979,-0.0145283785546555,"LOC100506123///LOC100506076","uncharacterized LOC100506123///uncharacterized LOC100506076",TRUE
+"220064_at",0.749080722577006,0.242185641207019,-1.20165166031638,-5.2598364595722,-0.640182974707574,"LOC100506124///TTC21B","uncharacterized LOC100506124///tetratricopeptide repeat domain 21B",TRUE
+"231232_at",0.673366993714442,0.139362911934783,-1.5332792964016,-4.85522935153546,-0.872457247205087,"LOC100506125","uncharacterized LOC100506125",TRUE
+"1558844_at",0.775805901298839,0.293198380321224,1.07670033449625,-5.39028252813416,0.849201193739094,"LOC100506127","putative uncharacterized protein FLJ37770-like",TRUE
+"1561198_at",0.986687088884629,0.937835475723025,-0.0788808506150017,-5.93665333645252,-0.0781756422645401,"LOC100506127","putative uncharacterized protein FLJ37770-like",TRUE
+"1556662_at",0.819370181128177,0.376318328638494,-0.902846809773995,-5.55027481270406,-0.427025026020657,"LOC100506142","uncharacterized LOC100506142",TRUE
+"1556663_s_at",0.885029460971826,0.545418166712138,-0.614077704375965,-5.75766649037851,-0.422968249509424,"LOC100506142","uncharacterized LOC100506142",TRUE
+"243710_at",0.95238233774064,0.782230098061975,0.279795163365745,-5.90162534892409,0.0885870924372947,"LOC100506175","uncharacterized LOC100506175",TRUE
+"242382_at",0.874834820370747,0.521496348564128,0.651386775719034,-5.73510682430597,0.19713259220006,"LOC100506207","uncharacterized LOC100506207",TRUE
+"1558661_at",0.983935461205724,0.92141709280648,0.0997789962709134,-5.93483551731621,0.0752918532991576,"LOC100506207","uncharacterized LOC100506207",TRUE
+"232364_at",0.812302873476553,0.359017013721111,-0.936688827770825,-5.52114444484571,-0.673961243166776,"LOC100506235","uncharacterized LOC100506235",TRUE
+"235873_at",0.919441662700044,0.657762988156363,0.44904161273571,-5.84194722117247,0.356505281187436,"LOC100506235","uncharacterized LOC100506235",TRUE
+"240096_at",0.975398143273847,0.882487790641562,0.149530514949307,-5.92879891796976,0.0874931935846366,"LOC100506236","uncharacterized LOC100506236",TRUE
+"200772_x_at",0.88113080359582,0.53725993424453,-0.626700470059767,-5.750177184023,-0.162146650001564,"LOC100506248///MIR1244-2///MIR1244-3///MIR1244-1///LOC728026///PTMA","prothymosin alpha///microRNA 1244-2///microRNA 1244-3///microRNA 1244-1///prothymosin alpha-like///prothymosin, alpha",TRUE
+"211921_x_at",0.958587459575795,0.812349178820025,-0.240245013744867,-5.91161036845552,-0.0584277267128837,"LOC100506248///MIR1244-2///MIR1244-3///MIR1244-1///LOC728026///PTMA","prothymosin alpha///microRNA 1244-2///microRNA 1244-3///microRNA 1244-1///prothymosin alpha-like///prothymosin, alpha",TRUE
+"216384_x_at",0.973859670116451,0.873686157821345,-0.160828114495182,-5.92709310748802,-0.0489462353059373,"LOC100506248///MIR1244-2///MIR1244-3///MIR1244-1///LOC728026///PTMA","prothymosin alpha///microRNA 1244-2///microRNA 1244-3///microRNA 1244-1///prothymosin alpha-like///prothymosin, alpha",TRUE
+"238216_at",0.772532966757283,0.282990763441465,1.10035103405923,-5.36656359833645,0.51507722786821,"LOC100506258","uncharacterized LOC100506258",TRUE
+"1557177_at",0.950958733458091,0.776090162700201,-0.287911799591955,-5.89938971086062,-0.258972642259996,"LOC100506258","uncharacterized LOC100506258",TRUE
+"1556247_a_at",0.87106619978761,0.511441710629177,0.667347061916804,-5.72506612508976,0.488719952006148,"LOC100506271","uncharacterized LOC100506271",TRUE
+"237312_at",0.739367922105944,0.227463949721876,1.24133444689437,-5.21579962977085,0.943748201654325,"LOC100506272","uncharacterized LOC100506272",TRUE
+"1556454_a_at",0.597654932724127,0.0735735689309183,1.87822711405681,-4.35360988130835,1.2521827673383,"LOC100506274","uncharacterized LOC100506274",TRUE
+"1556453_at",0.869056640409671,0.505536040432846,0.67680304081049,-5.71900750700892,0.401012491397311,"LOC100506274","uncharacterized LOC100506274",TRUE
+"220572_at",0.855075448726859,0.46720851311645,0.739765860435764,-5.67659476054917,0.381425439949894,"LOC100506282","uncharacterized LOC100506282",TRUE
+"243151_at",0.918482003504129,0.653837062016204,-0.45457531782478,-5.83953547899335,-0.40853112096045,"LOC100506282","uncharacterized LOC100506282",TRUE
+"237543_at",0.925511384407886,0.677479850453654,0.421460073536854,-5.85353552252183,0.312376565523524,"LOC100506286","uncharacterized LOC100506286",TRUE
+"240882_at",0.854184492233394,0.464362309113648,0.744559885637027,-5.6732186434617,0.398414086024652,"LOC100506289","uncharacterized LOC100506289",TRUE
+"243224_at",0.932742319779223,0.702981574201392,-0.386269355222365,-5.86727184363661,-0.13356395236767,"LOC100506302","uncharacterized LOC100506302",TRUE
+"1559976_at",0.694505490882266,0.16388414534006,1.43987245203263,-4.97738726402427,0.508831305110769,"LOC100506314","uncharacterized LOC100506314",TRUE
+"235373_at",0.99739139970986,0.986704045534945,-0.0168538652561421,-5.9395451300628,-0.0250701055606681,"LOC100506314","uncharacterized LOC100506314",TRUE
+"241568_at",0.676468346171966,0.143321704596261,1.51733515361205,-4.87651669562424,0.731387668880501,"LOC100506319","uncharacterized LOC100506319",TRUE
+"1556516_at",0.94149227422279,0.738402015746639,0.338192092510503,-5.88412919592828,0.235476400935755,"LOC100506331","uncharacterized LOC100506331",TRUE
+"1558440_at",0.930827859648584,0.693662177436567,0.399069667848404,-5.86241174486188,0.203554262875092,"LOC100506351","uncharacterized LOC100506351",TRUE
+"1561539_at",0.789406360796076,0.31617483499102,1.02554096147237,-5.44000794227055,0.705032067562144,"LOC100506368","uncharacterized LOC100506368",TRUE
+"244366_at",0.835765473744996,0.415154174694839,-0.830430766756931,-5.60926587130918,-0.502917265670948,"LOC100506371","uncharacterized LOC100506371",TRUE
+"237899_at",0.535335724323464,0.0428660228822702,2.14840750111539,-3.9114350697435,1.35887429709049,"LOC100506374","uncharacterized LOC100506374",TRUE
+"1559685_at",0.369623435296638,0.0110961177800291,2.77114178860942,-2.76375064577613,1.8965787425657,"LOC100506379","uncharacterized LOC100506379",TRUE
+"1560963_a_at",0.708473702007515,0.180558862012772,1.38262241136206,-5.04915915237716,1.09739506100633,"LOC100506379","uncharacterized LOC100506379",TRUE
+"1559686_a_at",0.943988850936011,0.749309043595256,-0.323555064183334,-5.88882211220163,-0.125713503001151,"LOC100506379","uncharacterized LOC100506379",TRUE
+"238091_at",0.88113080359582,0.537674198382919,-0.62605704248575,-5.75056249078419,-0.309158838952116,"LOC100506388","uncharacterized LOC100506388",TRUE
+"234250_at",0.8796702619256,0.534286055016467,0.631327299899106,-5.74739525858168,0.458988261051246,"LOC100506405","uncharacterized LOC100506405",TRUE
+"231284_at",0.993007207436969,0.966646662528808,0.0422895515357848,-5.93881245158239,0.0207612884489059,"LOC100506406","uncharacterized LOC100506406",TRUE
+"1565837_at",0.778665200947143,0.299061065486107,-1.06338305365484,-5.40343557547383,-0.782511839594157,"LOC100506411","uncharacterized LOC100506411",TRUE
+"1565836_at",0.812756730629488,0.361477922610284,0.931809759265557,-5.52540507967988,0.361750403628533,"LOC100506411","uncharacterized LOC100506411",TRUE
+"243245_at",0.708894565317004,0.181278907844071,-1.3802468199588,-5.05208533666575,-0.926159286110376,"LOC100506446","uncharacterized LOC100506446",TRUE
+"240661_at",0.949217179291784,0.770790458738276,-0.294933594603996,-5.8974044756723,-0.154274959984575,"LOC100506459","uncharacterized LOC100506459",TRUE
+"240887_at",0.821137675198948,0.382072991560243,0.891819329700288,-5.55955316542336,0.353626801320715,"LOC100506470","uncharacterized LOC100506470",TRUE
+"233679_at",0.64513208805899,0.116060099572979,1.63555872990465,-4.7145312785582,0.816293790362884,"LOC100506472","uncharacterized LOC100506472",TRUE
+"235480_at",0.91876780831279,0.654528423208101,0.453599783139464,-5.83996274675219,0.251000715121314,"LOC100506472","uncharacterized LOC100506472",TRUE
+"235827_at",0.991215113882097,0.958804104866081,-0.0522418888229006,-5.93835426819727,-0.0263781066649047,"LOC100506472///TAB1","uncharacterized LOC100506472///TGF-beta activated kinase 1 (MAP3K7) binding protein 1",TRUE
+"236958_at",0.814950844716166,0.365786344551505,-0.923321047354044,-5.53276904931013,-0.310922985972704,"LOC100506473","uncharacterized LOC100506473",TRUE
+"243680_at",0.765419357517701,0.265696327287869,1.14187572477062,-5.32381422267159,1.0434938124561,"LOC100506476","uncharacterized LOC100506476",TRUE
+"1559670_at",0.748237011093779,0.240750624019602,1.20543830568217,-5.25568783042783,0.5912126388606,"LOC100506489","uncharacterized LOC100506489",TRUE
+"1557434_at",0.755719147268412,0.25009569731458,-1.18107593816113,-5.28218046456737,-1.05276589549574,"LOC100506497","uncharacterized LOC100506497",TRUE
+"1560131_at",0.925838986533197,0.678965523622041,0.419395464362731,-5.85437393599166,0.125717275989362,"LOC100506497","uncharacterized LOC100506497",TRUE
+"1557921_s_at",0.975913043793143,0.884840128817041,-0.146514534280956,-5.92923334128965,-0.128593173420033,"LOC100506498","uncharacterized LOC100506498",TRUE
+"220846_s_at",0.936456142259101,0.7164192461069,0.367926903963614,-5.87396386833438,0.150271520339859,"LOC100506504","uncharacterized LOC100506504",TRUE
+"1559540_at",0.659382629906731,0.1273138644682,1.58422058143978,-4.78604025418515,1.18312202154728,"LOC100506526","uncharacterized LOC100506526",TRUE
+"231473_at",0.892806690390413,0.56615456355786,-0.582434471187338,-5.77579418171576,-0.384648743434976,"LOC100506530","uncharacterized LOC100506530",TRUE
+"1556571_at",0.927444355549168,0.682175323175471,0.41494117940966,-5.85616897944385,0.271207363795157,"LOC100506538","uncharacterized LOC100506538",TRUE
+"235509_at",0.446963972064621,0.0210986050523294,-2.48247774735005,-3.31502839712868,-1.0251590562065,"LOC100506538///NDUFAF6","uncharacterized LOC100506538///NADH:ubiquinone oxidoreductase complex assembly factor 6",TRUE
+"230016_at",0.704449222279154,0.176412447857224,-1.39645074413886,-5.03204308785461,-0.488185081666827,"LOC100506538///NDUFAF6","uncharacterized LOC100506538///NADH:ubiquinone oxidoreductase complex assembly factor 6",TRUE
+"224767_at",0.348891756023503,0.00920806225773965,2.85301559736157,-2.60238259612951,1.67776410811794,"LOC100506548///RPL37","uncharacterized LOC100506548///ribosomal protein L37",TRUE
+"224763_at",0.498703893437511,0.0313405867005265,2.29841314541911,-3.64981736636559,1.00147605230069,"LOC100506548///RPL37","uncharacterized LOC100506548///ribosomal protein L37",TRUE
+"224766_at",0.540483367247649,0.0450297984684526,2.12441888026969,-3.95225960406604,1.09012822326733,"LOC100506548///RPL37","uncharacterized LOC100506548///ribosomal protein L37",TRUE
+"1564584_at",0.635174103121116,0.105986007455867,1.68519301603192,-4.64373546810529,0.735438637656078,"LOC100506557","uncharacterized LOC100506557",TRUE
+"202350_s_at",0.803661715437398,0.34217582304885,0.97070016872576,-5.49087797744071,0.853614897359895,"LOC100506558///MATN2","uncharacterized LOC100506558///matrilin 2",TRUE
+"237196_at",0.985425981490741,0.929033453174364,0.0900794260532752,-5.93573207559185,0.0733145963087942,"LOC100506558///MATN2","uncharacterized LOC100506558///matrilin 2",TRUE
+"236289_at",0.907610731888632,0.616909025195988,0.507368996444314,-5.8150739243713,0.383791794243629,"LOC100506563","uncharacterized LOC100506563",TRUE
+"221109_at",0.990739624391638,0.95310201874599,-0.0594812695023215,-5.93796038787534,-0.0247451371357457,"LOC100506571","uncharacterized LOC100506571",TRUE
+"1570375_at",0.765228531154075,0.265221050607791,-1.14304448121494,-5.32259076936876,-0.867976078038669,"LOC100506585","uncharacterized LOC100506585",TRUE
+"213569_at",0.484495305292367,0.0278438984108096,-2.35403176584595,-3.55017819911787,-1.85190500562826,"LOC100506603","uncharacterized LOC100506603",TRUE
+"1557410_at",0.862206318655373,0.48516944855512,0.709902582148887,-5.69715887835591,0.467709462219815,"LOC100506606","uncharacterized LOC100506606",TRUE
+"232070_at",0.839051873022286,0.424864690426323,0.813006535554719,-5.62277274918098,0.61278573738629,"LOC100506639","uncharacterized LOC100506639",TRUE
+"214741_at",0.629131220810639,0.100074151392595,1.71621186066191,-4.59868035622254,0.676343465761986,"LOC100506639///ZNF131","uncharacterized LOC100506639///zinc finger protein 131",TRUE
+"221842_s_at",0.732320150624823,0.216711546618312,1.27157165588245,-5.18141921850908,0.430706946705927,"LOC100506639///ZNF131","uncharacterized LOC100506639///zinc finger protein 131",TRUE
+"237844_at",0.769847953580141,0.277829632660074,1.11254468968473,-5.35415577230951,0.900172124083984,"LOC100506639///ZNF131","uncharacterized LOC100506639///zinc finger protein 131",TRUE
+"1557384_at",0.831875452294783,0.407704404495944,0.843973531340288,-5.59858285185328,0.590218447751075,"LOC100506639///ZNF131","uncharacterized LOC100506639///zinc finger protein 131",TRUE
+"225916_at",0.835952408568777,0.416074102479186,0.828769156713505,-5.61056548036018,0.327401012674644,"LOC100506639///ZNF131","uncharacterized LOC100506639///zinc finger protein 131",TRUE
+"234835_at",0.776983560547865,0.296018049610091,1.07027181848015,-5.39665005115853,0.724194038159466,"LOC100506667","uncharacterized LOC100506667",TRUE
+"237617_at",0.599731655615302,0.076028800771218,1.86125508954986,-4.38002618735702,1.16710860680573,"LOC100506675","uncharacterized LOC100506675",TRUE
+"237267_at",0.867447813467579,0.499841960288329,0.685979274163158,-5.71305018101104,0.226883553675004,"LOC100506675","uncharacterized LOC100506675",TRUE
+"1570085_at",0.901781358899845,0.599018801147133,0.533471151517144,-5.8020120592754,0.216318708451423,"LOC100506679","uncharacterized LOC100506679",TRUE
+"241386_at",0.732727727932114,0.217010701388289,1.27071500642036,-5.18240299577065,1.05843634335245,"LOC100506691","uncharacterized LOC100506691",TRUE
+"216259_at",0.640890774222346,0.111404223469761,1.65802657128416,-4.68268412983935,1.23311302998029,"LOC100506699","uncharacterized LOC100506699",TRUE
+"204359_at",0.540713063686847,0.0450866183328456,2.12380306574898,-3.95330379841138,2.68770984524132,"LOC100506718///FLRT2","uncharacterized LOC100506718///fibronectin leucine rich transmembrane protein 2",TRUE
+"240259_at",0.620912785033482,0.0908370707412748,1.7679602058119,-4.52215623423159,1.67460854752474,"LOC100506718///FLRT2","uncharacterized LOC100506718///fibronectin leucine rich transmembrane protein 2",TRUE
+"204358_s_at",0.819018525257656,0.373818995872514,0.907670817099933,-5.54618283736552,0.728701638220409,"LOC100506718///FLRT2","uncharacterized LOC100506718///fibronectin leucine rich transmembrane protein 2",TRUE
+"229781_at",0.683970477958028,0.152981709646982,1.47989098852081,-4.92580828197685,0.536020785190328,"LOC100506725","uncharacterized LOC100506725",TRUE
+"1562013_a_at",0.920295529438727,0.660696853961177,-0.444915532729085,-5.84372662705092,-0.216999456087073,"LOC100506730","uncharacterized LOC100506730",TRUE
+"1562012_at",0.992342196993659,0.963935661725377,0.0457293097780138,-5.93866500037994,0.0296026237313232,"LOC100506730","uncharacterized LOC100506730",TRUE
+"1559970_at",0.860841863664955,0.480859101201488,0.717009561114045,-5.69233800673871,0.643631950151388,"LOC100506731","uncharacterized LOC100506731",TRUE
+"236914_at",0.909441642299191,0.623897302765537,-0.497270168310662,-5.81995608517248,-0.414102428140138,"LOC100506790","uncharacterized LOC100506790",TRUE
+"241234_at",0.769424525862551,0.276850490686158,1.11487654796845,-5.35176914174728,0.548193242014495,"LOC100506797","uncharacterized LOC100506797",TRUE
+"239263_at",0.909934011695618,0.62507792922058,-0.495569225844948,-5.82076895719554,-0.147570611732823,"LOC100506813","uncharacterized LOC100506813",TRUE
+"1559492_at",0.801455134542848,0.33816863593596,-0.978959944574863,-5.48337885949781,-1.11807572420685,"LOC100506844","uncharacterized LOC100506844",TRUE
+"226546_at",0.871451481476429,0.512666570959571,-0.665393511807785,-5.72630762521494,-0.535724140171084,"LOC100506844","uncharacterized LOC100506844",TRUE
+"240974_at",0.865345395265289,0.495085153786773,0.693690602735243,-5.7079846227497,0.590595626200984,"LOC100506851","uncharacterized LOC100506851",TRUE
+"239440_at",0.986342822130003,0.934688958682527,-0.0828828161357842,-5.93633812457202,-0.0560793365780352,"LOC100506858","uncharacterized LOC100506858",TRUE
+"239814_at",0.61748763243098,0.0876284689534884,1.78699541593033,-4.49358712335864,1.08055517447516,"LOC100506860","uncharacterized LOC100506860",TRUE
+"238874_at",0.819250502714397,0.376173458996707,0.903125846793548,-5.55003866782321,0.588179113997754,"LOC100506860","uncharacterized LOC100506860",TRUE
+"1563800_at",0.666643938027574,0.133371402350119,1.55813440568976,-4.82169332392191,0.516998887161085,"LOC100506870///LOC283140","uncharacterized LOC100506870///uncharacterized LOC283140",TRUE
+"227115_at",0.710372201621696,0.183125938937145,1.37418708630427,-5.0595306123675,0.566323074449116,"LOC100506870///LOC283140","uncharacterized LOC100506870///uncharacterized LOC283140",TRUE
+"237431_at",0.944354837333811,0.750509490476978,0.321948541155312,-5.88932468057238,0.19474951075845,"LOC100506882///USP32","uncharacterized LOC100506882///ubiquitin specific peptidase 32",TRUE
+"1558858_at",0.979883160726582,0.904041526059856,-0.12194539587081,-5.93244311554548,-0.0736786901715272,"LOC100506885","uncharacterized LOC100506885",TRUE
+"1569659_at",0.837368340567858,0.420347300258542,0.82108093615331,-5.61654701040842,0.354226672225734,"LOC100506895","uncharacterized LOC100506895",TRUE
+"239302_s_at",0.769847953580141,0.277899476220824,1.1123785836965,-5.35432561088699,1.20674517979846,"LOC100506922","uncharacterized LOC100506922",TRUE
+"231433_at",0.76912869907427,0.274857762196039,1.11964091754625,-5.34687910189662,0.446650263506183,"LOC100506929","uncharacterized LOC100506929",TRUE
+"227917_at",0.704148059811236,0.176104628621104,-1.39748759894308,-5.03075404004215,-0.803811580213027,"LOC100506990","uncharacterized LOC100506990",TRUE
+"238716_at",0.972881911890583,0.86862305866626,0.167336632767475,-5.92605415463192,0.158397046784285,"LOC100506990","uncharacterized LOC100506990",TRUE
+"1559665_at",0.980267546812478,0.908080679868486,-0.116787388194232,-5.93304246622074,-0.108702466459298,"LOC100506999","uncharacterized LOC100506999",TRUE
+"243699_at",0.760237493549547,0.258366711442291,1.160074405884,-5.30463904387312,0.876593879405877,"LOC100507006","uncharacterized LOC100507006",TRUE
+"235789_at",0.98693003519805,0.939746157942522,0.0764513565016642,-5.93683709025693,0.035039045170139,"LOC100507022///KDM4B","FLJ00291 protein///lysine demethylase 4B",TRUE
+"1561266_at",0.625205501341047,0.096425155603672,1.73614555689076,-4.56940247058194,1.15384330693056,"LOC100507033","uncharacterized LOC100507033",TRUE
+"1563099_at",0.705559553212919,0.177571152980421,-1.39256064801107,-5.03687231713509,-0.518804032396787,"LOC100507053","uncharacterized LOC100507053",TRUE
+"1559240_at",0.771011793494937,0.279629973346465,1.10827267699765,-5.3585166317468,0.779851475894002,"LOC100507053","uncharacterized LOC100507053",TRUE
+"1563143_at",0.859486825765374,0.477121376245437,0.723202466997713,-5.68809992841905,0.370676743061066,"LOC100507065","uncharacterized LOC100507065",TRUE
+"233249_at",0.538508613666048,0.0439757695168028,-2.13597131434309,-3.93263543247059,-1.12034211338379,"LOC100507073","uncharacterized LOC100507073",TRUE
+"233172_at",0.575270671804438,0.060878117031238,1.97482947295858,-4.20008857886416,1.42054352332344,"LOC100507073","uncharacterized LOC100507073",TRUE
+"1568812_at",0.766550448794594,0.267408094884692,1.13767900656451,-5.3281982531857,0.758182376827759,"LOC100507140","uncharacterized LOC100507140",TRUE
+"1562263_at",0.951684340070943,0.778544804073034,-0.284664567985502,-5.90029173717411,-0.101095063745368,"LOC100507156","uncharacterized LOC100507156",TRUE
+"236640_at",0.813631136157676,0.364360234738267,0.926123419575319,-5.53034484369745,0.751438826042945,"LOC100507165","uncharacterized LOC100507165",TRUE
+"1569372_at",0.816358096928248,0.367514847953694,0.919934209469514,-5.53568982123646,0.342719112421408,"LOC100507194","uncharacterized LOC100507194",TRUE
+"237668_at",0.957228789717225,0.806435709776507,-0.247977294380541,-5.90977693831127,-0.13421234587953,"LOC100507201","uncharacterized LOC100507201",TRUE
+"240734_at",0.945470838849769,0.753436935504059,0.318034438680357,-5.89053875986323,0.28161866775853,"LOC100507221","uncharacterized LOC100507221",TRUE
+"1557021_s_at",0.791353982620776,0.321896892061931,1.0132106266093,-5.45166630225712,0.618293702060946,"LOC100507250","uncharacterized LOC100507250",TRUE
+"231270_at",0.467673691528294,0.0245487035346575,2.41268027738797,-3.44365773268529,2.32112228405516,"LOC100507258///CA13","uncharacterized LOC100507258///carbonic anhydrase 13",TRUE
+"235899_at",0.588984479037728,0.0676833924425066,1.9210573367632,-4.28620039958429,1.25637407153019,"LOC100507258///CA13","uncharacterized LOC100507258///carbonic anhydrase 13",TRUE
+"237601_at",0.552420073963858,0.0501757264139816,-2.0712904304362,-4.04163164474104,-0.831355926199994,"LOC100507277","uncharacterized LOC100507277",TRUE
+"237747_at",0.568731573107512,0.058694793190969,1.99320967456998,-4.17028416612469,0.613621829380492,"LOC100507281","uncharacterized LOC100507281",TRUE
+"1568888_at",0.817889575750373,0.370821485016479,-0.913484588418539,-5.54122454827935,-0.672442914704115,"LOC100507283","uncharacterized LOC100507283",TRUE
+"1563776_at",0.943988850936011,0.749517438787602,0.323276112782558,-5.88890955420329,0.201011587829343,"LOC100507283","uncharacterized LOC100507283",TRUE
+"230334_at",0.75959865506602,0.257343606436925,-1.16264492526481,-5.30190914246148,-0.797749977575598,"LOC100507291","uncharacterized LOC100507291",TRUE
+"244655_at",0.982452968647666,0.915231083769552,0.107664168256209,-5.93403922947411,0.0405194607674506,"LOC100507311","uncharacterized LOC100507311",TRUE
+"244343_at",0.632216562924782,0.103290660664605,1.6991479090132,-4.62354231418889,0.636204696529607,"LOC100507330","uncharacterized LOC100507330",TRUE
+"229096_at",0.993083193605528,0.967033867359557,-0.0417983039381041,-5.93883256945111,-0.0208240755769422,"LOC100507334///LOC100288570///LIMS3-LOC440895///LOC440895","two pore channel 3 pseudogene///glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) pseudogene///LIMS3-LOC440895 readthrough///two pore channel 3 pseudogene",TRUE
+"229095_s_at",0.997901456792957,0.990260437686458,0.0123455226546924,-5.93960924679019,0.0105372680472611,"LOC100507334///LOC100288570///LIMS3-LOC440895///LOC440895","two pore channel 3 pseudogene///glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) pseudogene///LIMS3-LOC440895 readthrough///two pore channel 3 pseudogene",TRUE
+"1568682_a_at",0.505859475902822,0.0330763168971667,2.27288921604945,-3.69507862335672,0.769443730979464,"LOC100507336","uncharacterized LOC100507336",TRUE
+"1559017_at",0.450559234541437,0.02154938085644,2.47278048406694,-3.33301678747823,1.06567413695626,"LOC100507351","uncharacterized LOC100507351",TRUE
+"1562764_at",0.597654932724127,0.0745408119760385,-1.8714827872748,-4.36412743758286,-1.15755795805605,"LOC100507351","uncharacterized LOC100507351",TRUE
+"210770_s_at",0.406795337445118,0.0154520309596641,2.62378204226096,-3.04883876788812,1.54419625688706,"LOC100507353///CACNA1A","uncharacterized LOC100507353///calcium voltage-gated channel subunit alpha1 A",TRUE
+"214933_at",0.470858423822551,0.0253880317042319,2.39708153644373,-3.47213119051395,0.887994659081819,"LOC100507353///CACNA1A","uncharacterized LOC100507353///calcium voltage-gated channel subunit alpha1 A",TRUE
+"1558944_at",0.91539387234353,0.643141689739092,-0.469724795016076,-5.8327848532676,-0.385622044693583,"LOC100507353///CACNA1A","uncharacterized LOC100507353///calcium voltage-gated channel subunit alpha1 A",TRUE
+"1558945_s_at",0.953983577550391,0.787754859034907,0.272508139795474,-5.90357842453835,0.260825611517235,"LOC100507353///CACNA1A","uncharacterized LOC100507353///calcium voltage-gated channel subunit alpha1 A",TRUE
+"206399_x_at",0.994145854504594,0.973276406827545,-0.033879749210773,-5.9391244269331,-0.0152139765021992,"LOC100507353///CACNA1A","uncharacterized LOC100507353///calcium voltage-gated channel subunit alpha1 A",TRUE
+"224006_at",0.606900628956089,0.0806359207270167,1.83065714219357,-4.42721982327605,1.32796371241212,"LOC100507377","uncharacterized LOC100507377",TRUE
+"237170_at",0.554642754132296,0.0511741347420351,2.06155258162509,-4.05785378974599,1.17406833354671,"LOC100507384","uncharacterized LOC100507384",TRUE
+"1555485_s_at",0.807084045192774,0.34832669851164,0.958149336606801,-5.50216188880295,0.635267939928893,"LOC100507387///FAM153A///FAM153B","uncharacterized LOC100507387///family with sequence similarity 153 member A///family with sequence similarity 153 member B",TRUE
+"1563845_at",0.929325066560006,0.689272795594721,0.405121994383252,-5.8600594371262,0.41015285762581,"LOC100507387///FAM153A///FAM153B","uncharacterized LOC100507387///family with sequence similarity 153 member A///family with sequence similarity 153 member B",TRUE
+"221183_at",0.948989397056643,0.770033917542391,-0.295937194625002,-5.89711685852998,-0.180742674077536,"LOC100507388","uncharacterized LOC100507388",TRUE
+"1556387_at",0.356317777780208,0.00960607964239647,2.83450542034234,-2.63903911579539,0.998094064375931,"LOC100507389","uncharacterized LOC100507389",TRUE
+"1556388_a_at",0.767965891104819,0.270837607805037,1.12932991697402,-5.33687763656773,0.559349464957962,"LOC100507389","uncharacterized LOC100507389",TRUE
+"1559715_at",0.859947009633611,0.478409503152348,0.721065026617186,-5.68956659022522,0.516123963221515,"LOC100507391","uncharacterized LOC100507391",TRUE
+"240255_at",0.886023097762234,0.548440549665615,0.609426857604981,-5.76038888123544,0.317312738646722,"LOC100507395","uncharacterized LOC100507395",TRUE
+"1557540_at",0.675447258877226,0.141659518873975,1.52398505120274,-4.867659814115,0.487724671762906,"LOC100507403","uncharacterized LOC100507403",TRUE
+"220589_s_at",0.915766032166572,0.644754859323507,-0.467432748935861,-5.83382010596152,-0.174520341788904,"LOC100507424///ITFG2","uncharacterized LOC100507424///integrin alpha FG-GAP repeat containing 2",TRUE
+"214148_at",0.938500267760216,0.726470996566489,0.354290172581316,-5.8787308146468,0.168643914111096,"LOC100507424///ITFG2","uncharacterized LOC100507424///integrin alpha FG-GAP repeat containing 2",TRUE
+"226295_at",0.995261077491356,0.978043103139696,-0.0278347983751543,-5.93930612297065,-0.016098470391146,"LOC100507424///ITFG2","uncharacterized LOC100507424///integrin alpha FG-GAP repeat containing 2",TRUE
+"1552972_at",0.774209477315394,0.285970112481032,1.09338525682984,-5.37359716362064,1.49325178477743,"LOC100507431","uncharacterized LOC100507431",TRUE
+"227009_at",0.867924303277286,0.501183295663073,0.683812359384038,-5.71446388628418,0.388685279379574,"LOC100507431","uncharacterized LOC100507431",TRUE
+"240740_at",0.821896104057596,0.384879337667766,0.886481126349091,-5.5640067286908,0.511224813516175,"LOC100507443","uncharacterized LOC100507443",TRUE
+"237684_at",0.908709061737317,0.620646870182693,-0.501960817342863,-5.81770035915408,-0.361319826077391,"LOC100507461","uncharacterized LOC100507461",TRUE
+"239113_at",0.800342373547779,0.336100565424394,-0.983249022565989,-5.47946193174762,-0.558550785446066,"LOC100507468","uncharacterized LOC100507468",TRUE
+"210553_x_at",0.547343369043481,0.0479157461892629,2.09399047945322,-4.00362381635218,1.94972192774103,"LOC100507472///PCSK6","uncharacterized LOC100507472///proprotein convertase subtilisin/kexin type 6",TRUE
+"207414_s_at",0.648475230160564,0.11954242057226,1.61924393001262,-4.73744743113772,1.80222636252863,"LOC100507472///PCSK6","uncharacterized LOC100507472///proprotein convertase subtilisin/kexin type 6",TRUE
+"1555868_at",0.65284137151906,0.122173039240473,1.60718122354199,-4.75427683179483,0.733049795123508,"LOC100507477","uncharacterized LOC100507477",TRUE
+"1555869_a_at",0.68865058167867,0.15785341076015,1.46173281501279,-4.94935410092622,0.764210958483119,"LOC100507477","uncharacterized LOC100507477",TRUE
+"231607_at",0.939166148226364,0.727677095382225,0.352658558005604,-5.87928926200523,0.117738696104994,"LOC100507480","uncharacterized LOC100507480",TRUE
+"229006_at",0.745494920282811,0.237017616813463,1.21536903563078,-5.24475400276118,0.79151709999718,"LOC100507487","uncharacterized LOC100507487",TRUE
+"1566455_at",0.816800680706682,0.368998204178419,0.917036161270159,-5.538181215022,0.573463547088392,"LOC100507494","uncharacterized LOC100507494",TRUE
+"1566454_at",0.994098505325585,0.972844452210171,-0.0344275988228107,-5.93910620100634,-0.0112584479718691,"LOC100507494","uncharacterized LOC100507494",TRUE
+"1560412_at",0.948109877411639,0.764250416403057,0.303619723884166,-5.8948830702058,0.222583290483715,"LOC100507506","uncharacterized LOC100507506",TRUE
+"241353_s_at",0.717967110215679,0.193900383210382,1.33976999047529,-5.10129831744606,0.695919624301366,"LOC100507507","uncharacterized LOC100507507",TRUE
+"231402_at",0.867972140419125,0.501343582097308,0.683553638027382,-5.71463239163031,0.543553396504532,"LOC100507507","uncharacterized LOC100507507",TRUE
+"238016_s_at",0.94214388523134,0.73974487818213,0.336385989617141,-5.88471937568506,0.297811887655114,"LOC100507507","uncharacterized LOC100507507",TRUE
+"237709_at",0.733138545080793,0.217615097359235,1.26898704471032,-5.18438566530962,0.701454762082276,"LOC100507513","uncharacterized LOC100507513",TRUE
+"1556190_s_at",0.661974206478491,0.129573779872335,-1.57437046660387,-4.79955736070928,-1.0430866433987,"LOC100507516","uncharacterized LOC100507516",TRUE
+"231305_at",0.482262518773694,0.0274935943487445,2.35995293231886,-3.53949058498584,0.731893457225522,"LOC100507520","uncharacterized LOC100507520",TRUE
+"236553_at",0.874982802483487,0.521816767807288,-0.650880964672707,-5.73542122088367,-0.236007659104548,"LOC100507520","uncharacterized LOC100507520",TRUE
+"244037_at",0.9129554654276,0.63480252270985,0.481614533410518,-5.82733507753375,0.276868064929219,"LOC100507520","uncharacterized LOC100507520",TRUE
+"1561055_at",0.923050713409153,0.670194573637702,0.431611492161257,-5.84935430049114,0.33529294072709,"LOC100507534","uncharacterized LOC100507534",TRUE
+"235617_x_at",0.939166148226364,0.727476787420144,-0.352929467618275,-5.87919671499747,-0.341463762556724,"LOC100507537","uncharacterized LOC100507537",TRUE
+"231739_at",0.744573608322482,0.235662056173972,1.21900438506019,-5.24073202091295,0.844150575078118,"LOC100507547///PRRT1","uncharacterized LOC100507547///proline rich transmembrane protein 1",TRUE
+"229890_at",0.778580821633075,0.298666327874285,1.06427382522172,-5.40256036267549,0.501063490076064,"LOC100507547///PRRT1","uncharacterized LOC100507547///proline rich transmembrane protein 1",TRUE
+"230054_at",0.982643521157831,0.915739687700394,-0.107015604897958,-5.93410700730511,-0.0846287481965131,"LOC100507547///PRRT1","uncharacterized LOC100507547///proline rich transmembrane protein 1",TRUE
+"241745_at",0.769258076576208,0.276412319238407,1.11592201300113,-5.3506976823527,0.86352368809237,"LOC100507557","uncharacterized LOC100507557",TRUE
+"231379_at",0.9340157600858,0.707621343435589,0.379921120328024,-5.8696242492248,0.168670522208709,"LOC100507560","uncharacterized LOC100507560",TRUE
+"237712_at",0.593339168375633,0.0701485253206269,-1.90274953659568,-4.3151443578456,-1.26178582947867,"LOC100507562","uncharacterized LOC100507562",TRUE
+"1556048_at",0.955904644595647,0.800217557099487,0.25612468132118,-5.90778262402641,0.0814796552799368,"LOC100507564","uncharacterized LOC100507564",TRUE
+"223098_s_at",0.581406183553129,0.0639080179050675,-1.95026586091948,-4.23962706620816,-0.905854249024639,"LOC100507577///LONP2","uncharacterized LOC100507577///lon peptidase 2, peroxisomal",TRUE
+"221834_at",0.627833079574546,0.0991892623752446,-1.72098814721645,-4.59168808099329,-0.802588245652817,"LOC100507577///LONP2","uncharacterized LOC100507577///lon peptidase 2, peroxisomal",TRUE
+"223099_s_at",0.691295036264984,0.160987539886783,-1.45028959925758,-4.964071454075,-0.676057319434429,"LOC100507577///LONP2","uncharacterized LOC100507577///lon peptidase 2, peroxisomal",TRUE
+"229663_at",0.879447209955825,0.533881583051766,-0.631957657809855,-5.74701472573276,-0.23343029856942,"LOC100507577///LONP2","uncharacterized LOC100507577///lon peptidase 2, peroxisomal",TRUE
+"221833_at",0.314126572995991,0.00663883585272678,-2.9949306567915,-2.31819328518529,-2.26653242407264,"LOC100507577///LONP2///SIAH1","uncharacterized LOC100507577///lon peptidase 2, peroxisomal///siah E3 ubiquitin protein ligase 1",TRUE
+"1557386_at",0.819820231734094,0.377904513953258,0.899796240960666,-5.55285206444852,0.320775975882425,"LOC100507600","uncharacterized LOC100507600",TRUE
+"239244_at",0.737123149977386,0.223111695862342,1.25343898038647,-5.202121669308,0.779053156638946,"LOC100507616","uncharacterized LOC100507616",TRUE
+"1558186_s_at",0.897024165042344,0.58297531830654,0.557201691925919,-5.78958414382048,0.469777888229438,"LOC100507616///CLLU1","uncharacterized LOC100507616///chronic lymphocytic leukemia up-regulated 1",TRUE
+"1558185_at",0.978072252406502,0.893715498219605,0.135147518545677,-5.9307912585633,0.0770954291359764,"LOC100507616///CLLU1","uncharacterized LOC100507616///chronic lymphocytic leukemia up-regulated 1",TRUE
+"207476_at",0.83171794972459,0.406450331937656,0.846268708762806,-5.59675634337866,0.589195617271617,"LOC100507630","uncharacterized LOC100507630",TRUE
+"1557566_at",0.468732760220321,0.0248018998686308,-2.40792337085103,-3.45235162216344,-2.2104783639138,"LOC100507634","uncharacterized LOC100507634",TRUE
+"1557567_a_at",0.581128536542197,0.0636186655307282,-1.95256670240381,-4.23593786918407,-1.33544717401152,"LOC100507634","uncharacterized LOC100507634",TRUE
+"233176_at",0.995261077491356,0.978026164190903,-0.0278562777151228,-5.93930554036383,-0.0332929010324818,"LOC100507642","uncharacterized LOC100507642",TRUE
+"1566656_a_at",0.68033297785336,0.147827707595936,1.49962054133376,-4.89995938501487,0.475848369562935,"LOC100507654","uncharacterized LOC100507654",TRUE
+"1566658_at",0.833905640519001,0.411591725926763,0.836887457818678,-5.60419274221454,0.618371625821927,"LOC100507654","uncharacterized LOC100507654",TRUE
+"1556502_at",0.929088231432081,0.687736164660493,0.407244419400776,-5.85922627787478,0.209299572401162,"LOC100507654","uncharacterized LOC100507654",TRUE
+"236080_at",0.87106619978761,0.511519386860188,-0.66722309736111,-5.72514500937309,-0.262969916117016,"LOC100507670","uncharacterized LOC100507670",TRUE
+"230630_at",0.800393752157075,0.336203542395438,0.983035024851198,-5.47965773114515,0.76637937761185,"LOC100507855///AK4","adenylate kinase 4, mitochondrial-like///adenylate kinase 4",TRUE
+"204348_s_at",0.812302873476553,0.359143974515059,0.936436563414145,-5.52136523521391,0.678480137326654,"LOC100507855///AK4","adenylate kinase 4, mitochondrial-like///adenylate kinase 4",TRUE
+"204347_at",0.835952408568777,0.416263996644036,0.828426451120028,-5.61083322061941,0.686631133649437,"LOC100507855///AK4","adenylate kinase 4, mitochondrial-like///adenylate kinase 4",TRUE
+"225342_at",0.867377496843753,0.499707796489829,0.686196195819264,-5.7129084249669,0.472942397532861,"LOC100507855///AK4","adenylate kinase 4, mitochondrial-like///adenylate kinase 4",TRUE
+"200018_at",0.89085645983207,0.559843832650003,0.591999658990718,-5.770412212747,0.125521855554522,"LOC100508408///SNORD14B///RPS13","uncharacterized LOC100508408///small nucleolar RNA, C/D box 14B///ribosomal protein S13",TRUE
+"1558574_at",0.996261754016157,0.981951580858698,0.0228790124921298,-5.93942853115306,0.0199594296771597,"LOC100508631","uncharacterized LOC100508631",TRUE
+"241766_at",0.728156825353177,0.208320612748415,1.29597963930234,-5.15315184070143,0.748745043310873,"LOC100509303","uncharacterized LOC100509303",TRUE
+"228245_s_at",0.697172073261335,0.167339704390475,1.4276372838915,-4.99292682916081,0.853176252173055,"LOC100509445///LOC728715///OVOS///OVOS2","uncharacterized LOC100509445///ovostatin homolog 2///ovostatin///ovostatin 2",TRUE
+"236203_at",0.69385705848116,0.163276755850368,1.44204445587202,-4.97461733911257,1.15109449968889,"LOC100509457///HLA-DQA1","HLA class II histocompatibility antigen, DQ alpha 1 chain-like///major histocompatibility complex, class II, DQ alpha 1",TRUE
+"213831_at",0.917102138198416,0.649262532204677,-0.461041495713878,-5.83668065978401,-0.299846547929296,"LOC100509457///HLA-DQA1","HLA class II histocompatibility antigen, DQ alpha 1 chain-like///major histocompatibility complex, class II, DQ alpha 1",TRUE
+"212671_s_at",0.966669305339833,0.845135061080006,-0.197631773620724,-5.92067749997511,-0.13163952086486,"LOC100509457///HLA-DQA2///HLA-DQA1","HLA class II histocompatibility antigen, DQ alpha 1 chain-like///major histocompatibility complex, class II, DQ alpha 2///major histocompatibility complex, class II, DQ alpha 1",TRUE
+"208332_at",0.542397752248982,0.0455372115500573,2.11894412660664,-3.9615360248786,0.580105181209077,"LOC100509646///PRY2///PRY","PTPN13-like protein, Y-linked-like///PTPN13-like, Y-linked 2///PTPN13-like, Y-linked",TRUE
+"215189_at",0.615821255316333,0.0868310153278678,1.79181937901547,-4.48631160561361,2.08222667746892,"LOC100509764///KRT86","uncharacterized LOC100509764///keratin 86",TRUE
+"1562414_at",0.511558158080054,0.0341027105966554,2.25836672193225,-3.72069794643816,1.73966527789907,"LOC100509814","uncharacterized LOC100509814",TRUE
+"216400_at",0.990627530017502,0.9527706063894,0.0599021276921074,-5.93793592033058,0.0426650230173173,"LOC100510710///GBAP1","glucosylceramidase-like///glucosylceramidase beta pseudogene 1",TRUE
+"1564166_s_at",0.897699110987203,0.585248922014428,0.553819296168217,-5.79138763563193,0.339735982020174,"LOC100630923","LOC100289561-PRKRIP1 readthrough",TRUE
+"1564165_at",0.950214160603623,0.773861495944311,0.290862830147496,-5.89856116126631,0.130383320217186,"LOC100630923","LOC100289561-PRKRIP1 readthrough",TRUE
+"222615_s_at",0.833430578034454,0.410879543915314,-0.838182480301074,-5.60317080040432,-0.264127264896301,"LOC100630923///LOC100289561///PRKRIP1","LOC100289561-PRKRIP1 readthrough///uncharacterized LOC100289561///PRKR interacting protein 1 (IL11 inducible)",TRUE
+"218378_s_at",0.896229101808264,0.580030915288455,-0.561591815274514,-5.78722744223514,-0.20241210708784,"LOC100630923///LOC100289561///PRKRIP1","LOC100289561-PRKRIP1 readthrough///uncharacterized LOC100289561///PRKR interacting protein 1 (IL11 inducible)",TRUE
+"1568690_a_at",0.64513208805899,0.115734422777516,1.63710545281758,-4.71234954457963,1.16841798700601,"LOC100631378","uncharacterized 100631378",TRUE
+"1568689_at",0.9832781796011,0.918472538142801,-0.103531516811353,-5.9344641088229,-0.0758252080208073,"LOC100631378","uncharacterized 100631378",TRUE
+"232248_at",0.988446943949097,0.944911190742608,-0.0698861670935631,-5.93730490719105,-0.0486795110856919,"LOC100652768","uncharacterized LOC100652768",TRUE
+"207222_at",0.822232806605564,0.386886799444197,0.882678143701686,-5.56716437108291,0.954364400014501,"LOC100652777///PLA2G10","group 10 secretory phospholipase A2-like///phospholipase A2 group X",TRUE
+"1556914_at",0.859465912277024,0.476810878427426,0.723718193048041,-5.68774543116804,0.258366340518508,"LOC100652911","uncharacterized LOC100652911",TRUE
+"218822_s_at",0.296964617886988,0.00540192755769464,-3.08339947925244,-2.13843761904976,-1.81417011392312,"LOC100652930///STX16-NPEPL1///NPEPL1","uncharacterized LOC100652930///STX16-NPEPL1 readthrough (NMD candidate)///aminopeptidase-like 1",TRUE
+"218821_at",0.585036027492332,0.0656057157985228,-1.93694848658406,-4.26092173042386,-1.11412442125102,"LOC100652930///STX16-NPEPL1///NPEPL1","uncharacterized LOC100652930///STX16-NPEPL1 readthrough (NMD candidate)///aminopeptidase-like 1",TRUE
+"1552952_at",0.88113080359582,0.537111170911664,0.626931591600952,-5.75003868740133,0.287567616511957,"LOC100652931///RBMY2FP","RNA binding motif protein, Y-linked, family 1, member A1 pseudogene///RNA binding motif protein, Y-linked, family 2, member F pseudogene",TRUE
+"216544_at",0.93523910610914,0.711900385237741,-0.374080505708239,-5.87175459307726,-0.208231184439791,"LOC100652931///RBMY2FP","RNA binding motif protein, Y-linked, family 1, member A1 pseudogene///RNA binding motif protein, Y-linked, family 2, member F pseudogene",TRUE
+"232732_at",0.968066640321622,0.850192858845029,0.191093143163462,-5.92191323134653,0.0831760783972832,"LOC100652999","uncharacterized LOC100652999",TRUE
+"234272_at",0.699391325858549,0.170947993713603,1.41507594315757,-5.00876756213995,0.907799491878084,"LOC100653005","uncharacterized LOC100653005",TRUE
+"206969_at",0.975398143273847,0.882065853917627,-0.150071638024432,-5.92872003981791,-0.133279413269773,"LOC100653049///KRT34","keratin, type I cuticular Ha4///keratin 34",TRUE
+"209616_s_at",0.886783047600321,0.5499520191576,0.607106085266321,-5.76173988632864,0.969682612758603,"LOC100653057///CES1","liver carboxylesterase 1-like///carboxylesterase 1",TRUE
+"232207_at",0.710383535193614,0.18335466102631,1.37344006950495,-5.06044654745346,0.551496011704756,"LOC100653061///GUSBP4","putative inactive beta-glucuronidase-like protein SMA3///glucuronidase, beta pseudogene 4",TRUE
+"231672_at",0.868362470085218,0.503006829768691,0.680871716191047,-5.7163755374303,0.414641743843858,"LOC100653086","uncharacterized LOC100653086",TRUE
+"224527_at",0.919485127002411,0.658100632606775,-0.448566360092868,-5.84215299875682,-0.22187405309234,"LOC100653137///CDH23","cadherin-23-like///cadherin-related 23",TRUE
+"232845_at",0.939976205834042,0.730008731206704,-0.349507072969738,-5.88036069893626,-0.296172112567779,"LOC100653137///CDH23","cadherin-23-like///cadherin-related 23",TRUE
+"1552436_a_at",0.941106542715586,0.735955103521446,-0.341486060176134,-5.88304477915141,-0.297671014995546,"LOC100653137///CDH23","cadherin-23-like///cadherin-related 23",TRUE
+"232846_s_at",0.954506242294505,0.791528284915695,-0.267539757372266,-5.90488071698732,-0.270732271030415,"LOC100653137///CDH23","cadherin-23-like///cadherin-related 23",TRUE
+"1558139_at",0.308621629697291,0.00629597383593616,3.01775037873807,-2.27200686984932,1.49326583184255,"LOC100653149///LINC01296","uncharacterized LOC100653149///long intergenic non-protein coding RNA 1296",TRUE
+"233511_at",0.98529096111871,0.926685940054859,0.0930680376143351,-5.93546558610194,0.0270258893393418,"LOC100653233///DKFZp434L192","uncharacterized LOC100653233///uncharacterized protein DKFZp434L192",TRUE
+"226440_at",0.996296795497044,0.982138174370364,0.0226424354384937,-5.93943377636568,0.00835788846907626,"LOC100653247///DUSP22","dual specificity protein phosphatase 22-like///dual specificity phosphatase 22",TRUE
+"231811_at",0.640067422642767,0.110410087666149,1.6629261881506,-4.67569508754675,1.2058931826284,"LOC100653296///LOC100288778///WASH1///LOC100134445///WASH7P///WASH5P///WASH2P///WASH3P","uncharacterized LOC100653296///WAS protein family homolog 1 pseudogene///WAS protein family homolog 1///uncharacterized LOC100134445///WAS protein family homolog 7 pseudogene///WAS protein family homolog 5 pseudogene///WAS protein family homolog 2 pseudogene///WAS protein family homolog 3 pseudogene",TRUE
+"1557034_s_at",0.805156059006033,0.344365949422073,0.96621372710087,-5.49492695022341,0.673976441375522,"LOC100653296///LOC100288778///WASH1///LOC100134445///WASH7P///WASH5P///WASH2P///WASH3P","uncharacterized LOC100653296///WAS protein family homolog 1 pseudogene///WAS protein family homolog 1///uncharacterized LOC100134445///WAS protein family homolog 7 pseudogene///WAS protein family homolog 5 pseudogene///WAS protein family homolog 2 pseudogene///WAS protein family homolog 3 pseudogene",TRUE
+"238141_s_at",0.968980656821882,0.853465588262881,0.186866773415287,-5.922689927916,0.155823927629363,"LOC100996246","uncharacterized LOC100996246",TRUE
+"1568892_at",0.319095917986488,0.00703809722991732,2.9697415292914,-2.36902414480582,1.27479717956136,"LOC100996251","uncharacterized LOC100996251",TRUE
+"234423_x_at",0.881837330151173,0.538747367883669,-0.624391451220126,-5.75155813443636,-0.273098083297843,"LOC100996255","uncharacterized LOC100996255",TRUE
+"237787_at",0.908709061737317,0.620667747552074,-0.501930653199505,-5.81771493108319,-0.362029409350356,"LOC100996263","uncharacterized LOC100996263",TRUE
+"1559205_s_at",0.894136768148992,0.570394119502543,0.576039287326391,-5.77934518108484,0.403346399805365,"LOC100996286","uncharacterized LOC100996286",TRUE
+"220837_at",0.958933497686198,0.814170374675812,0.237866705689295,-5.91216268483172,0.242225843117418,"LOC100996325","uncharacterized LOC100996325",TRUE
+"1569426_at",0.930899509890345,0.694502649921359,0.397912512414793,-5.86285751678703,0.312597193980758,"LOC100996342","uncharacterized LOC100996342",TRUE
+"240697_at",0.870525641150512,0.509705301328785,0.670120970931673,-5.72329728993297,0.410823118373721,"LOC100996345","uncharacterized LOC100996345",TRUE
+"237977_at",0.55074985379986,0.0490346038482887,2.08263503001359,-4.02267028339447,0.595903238677089,"LOC100996349","testis expressed 264 pseudogene",TRUE
+"1558587_at",0.812644903778517,0.361301489010498,0.932158818888372,-5.52510094336848,0.888579456236694,"LOC100996385","uncharacterized LOC100996385",TRUE
+"1566039_a_at",0.878019928703403,0.52979891116331,0.638334902520995,-5.74314438769384,0.371697132561846,"LOC100996385","uncharacterized LOC100996385",TRUE
+"239558_at",0.838999550222784,0.424512654018329,0.813633831287118,-5.62229114184681,0.700063293047059,"LOC100996404","uncharacterized LOC100996404",TRUE
+"230292_at",0.919354071504066,0.656743394835226,-0.450477383244584,-5.84132425514878,-0.281324102601536,"LOC100996412","uncharacterized LOC100996412",TRUE
+"1559534_at",0.262143723862999,0.00391717279188056,-3.22001608131626,-1.85742204058589,-2.11408460444717,"LOC100996419","uncharacterized LOC100996419",TRUE
+"1559535_s_at",0.475296051772729,0.0262336965836065,-2.38183981521006,-3.49985407612793,-2.14880256117725,"LOC100996419","uncharacterized LOC100996419",TRUE
+"1556639_at",0.722288531465626,0.198685851174712,1.32496419539892,-5.11899290193702,0.776366235427997,"LOC100996455","uncharacterized LOC100996455",TRUE
+"1566473_a_at",0.724067243569133,0.201297540700136,1.31700112817417,-5.12844115330702,1.10196969539308,"LOC100996506","uncharacterized LOC100996506",TRUE
+"1566471_at",0.748136676097718,0.240155650150178,-1.207013272811,-5.25395896811265,-0.386884372696052,"LOC100996506","uncharacterized LOC100996506",TRUE
+"1566472_s_at",0.804656080879986,0.343583268836858,0.967814793752081,-5.49348396757009,0.403659768761159,"LOC100996506///RETSAT","uncharacterized LOC100996506///retinol saturase",TRUE
+"241049_at",0.905392572242204,0.611162755624015,-0.515713180236256,-5.81096780146794,-0.234287843908419,"LOC100996542","uncharacterized LOC100996542",TRUE
+"207548_at",0.851733415458562,0.456088567975243,0.75859612507384,-5.66321508894302,0.392331596581727,"LOC100996542///GRM7","uncharacterized LOC100996542///glutamate metabotropic receptor 7",TRUE
+"217008_s_at",0.916008366263392,0.645507940909156,-0.466363615326824,-5.83430130772203,-0.177327899293615,"LOC100996542///GRM7","uncharacterized LOC100996542///glutamate metabotropic receptor 7",TRUE
+"1558320_at",0.844923796356021,0.441941119857147,-0.782957022877155,-5.64543425068041,-0.48039654032052,"LOC100996549","uncharacterized LOC100996549",TRUE
+"236598_at",0.883515015273005,0.541731945577232,0.619768614956944,-5.75430814981977,0.405546507337489,"LOC100996579","uncharacterized LOC100996579",TRUE
+"236451_at",0.930827859648584,0.693529351931375,0.399252591593641,-5.86234116031673,0.452811273293928,"LOC100996579","uncharacterized LOC100996579",TRUE
+"244600_at",0.812302873476553,0.360537257398417,-0.933672110220392,-5.52378119894572,-0.693638007126255,"LOC100996583","uncharacterized LOC100996583",TRUE
+"1561877_at",0.838305466071775,0.423208184261786,0.81596111212573,-5.62050132463765,0.650592396406553,"LOC100996624","uncharacterized LOC100996624",TRUE
+"1553446_at",0.860085676417428,0.479206780325593,0.71974375685372,-5.69047115003266,0.470144927167172,"LOC100996634","transmembrane protein FLJ37396",TRUE
+"240609_at",0.88587213211399,0.547855407465393,-0.610326214988759,-5.75986399594448,-0.432196131079306,"LOC100996654","uncharacterized LOC100996654",TRUE
+"237848_at",0.927041268353741,0.681386920316888,-0.416034463164951,-5.85573013963937,-0.311719906283097,"LOC100996671","uncharacterized LOC100996671",TRUE
+"1569515_a_at",0.660234446131062,0.128275072262376,1.58001343459797,-4.79182170353213,0.990715407231322,"LOC100996681","uncharacterized LOC100996681",TRUE
+"205265_s_at",0.499983604958508,0.0316697580004497,2.29347485510275,-3.65859747527915,1.8523361627805,"LOC100996693///SPEG","CAVP-target protein-like///SPEG complex locus",TRUE
+"232153_at",0.499983604958508,0.0317011564757785,2.29300626878416,-3.65943003239643,1.73761265225985,"LOC100996693///SPEG","CAVP-target protein-like///SPEG complex locus",TRUE
+"1559474_at",0.926975296740084,0.681172135292663,0.416332396406473,-5.85561035350496,0.183692568623643,"LOC100996693///SPEG","CAVP-target protein-like///SPEG complex locus",TRUE
+"231347_at",0.986421906591669,0.936139473570679,0.0810377792492269,-5.93648538403738,0.0527638947245661,"LOC100996694","uncharacterized LOC100996694",TRUE
+"201064_s_at",0.620912785033482,0.0909798769350501,1.76712652137521,-4.52340235188743,0.5801147347668,"LOC100996696///PABPC4","polyadenylate-binding protein 4 pseudogene///poly(A) binding protein cytoplasmic 4",TRUE
+"232509_at",0.966089564318167,0.842058789112331,0.201613020080763,-5.91990480149666,0.128657486870266,"LOC100996724","phosphodiesterase 4D interacting protein-like",TRUE
+"228158_at",0.867267132647906,0.499533178625475,-0.686478574807912,-5.71272382907971,-0.641591986357563,"LOC100996735///LOC100996732///LOC654342///LOC645166","uncharacterized LOC100996735///uncharacterized LOC100996732///lymphocyte-specific protein 1 pseudogene///lymphocyte-specific protein 1 pseudogene",TRUE
+"229872_s_at",0.62110896023334,0.091628911583215,1.76335164584894,-4.52903929951091,1.5485936237645,"LOC100996740","uncharacterized LOC100996740",TRUE
+"1558588_at",0.454713655038042,0.0220641120588189,2.46193538983184,-3.35309009302113,2.05065962933742,"LOC100996741///LINC00869","uncharacterized LOC100996741///long intergenic non-protein coding RNA 869",TRUE
+"222315_at",0.565043084457947,0.0564017974534621,-2.01317810384721,-4.13769450561062,-2.31503749297235,"LOC100996756","uncharacterized LOC100996756",TRUE
+"1557094_at",0.0823353801878483,0.000302228351104372,4.277563784744,0.398807216524375,4.91507051020849,"LOC100996760","uncharacterized LOC100996760",TRUE
+"221650_s_at",0.952613441433926,0.782802008055569,-0.279040116645374,-5.90183009297843,-0.184187067689423,"LOC100996782///MED18","mediator of RNA polymerase II transcription subunit 18-like///mediator complex subunit 18",TRUE
+"219730_at",0.961395512423249,0.824747274562993,0.224081502827748,-5.91525636378873,0.181346176046225,"LOC100996782///MED18","mediator of RNA polymerase II transcription subunit 18-like///mediator complex subunit 18",TRUE
+"207667_s_at",0.637349652490244,0.108166300102618,1.67412313918091,-4.6596643804402,0.56316880999494,"LOC100996792///MAP2K3","dual specificity mitogen-activated protein kinase kinase 3///mitogen-activated protein kinase kinase 3",TRUE
+"215498_s_at",0.673366993714442,0.139648986588533,1.53211473365073,-4.85679017106418,0.673518009478443,"LOC100996792///MAP2K3","dual specificity mitogen-activated protein kinase kinase 3///mitogen-activated protein kinase kinase 3",TRUE
+"215499_at",0.748237011093779,0.240804361174323,1.20529620134045,-5.25584372388192,0.51326050013232,"LOC100996792///MAP2K3","dual specificity mitogen-activated protein kinase kinase 3///mitogen-activated protein kinase kinase 3",TRUE
+"204670_x_at",0.699161781955613,0.170589845564619,-1.41631319548413,-5.00721240369584,-1.09488693528944,"LOC100996809///HLA-DRB4///HLA-DRB1","HLA class II histocompatibility antigen, DRB1-10 beta chain-like///major histocompatibility complex, class II, DR beta 4///major histocompatibility complex, class II, DR beta 1",TRUE
+"238900_at",0.916349280948806,0.646825332404678,-0.464494668144962,-5.83513990227743,-0.398995896599755,"LOC100996809///HLA-DRB5///HLA-DRB4///HLA-DRB3///HLA-DRB1","HLA class II histocompatibility antigen, DRB1-10 beta chain-like///major histocompatibility complex, class II, DR beta 5///major histocompatibility complex, class II, DR beta 4///major histocompatibility complex, class II, DR beta 3///major histocompatibility complex, class II, DR beta 1",TRUE
+"208566_at",0.923494952314901,0.671626780357308,0.429612222852948,-5.8501855018515,0.20894834002704,"LOC100996843","ATP-sensitive inward rectifier potassium channel 12-like",TRUE
+"232289_at",0.460923452344129,0.0231241523507992,2.44032207236701,-3.3929534060759,1.6154241866941,"LOC100996843///KCNJ18///KCNJ12","ATP-sensitive inward rectifier potassium channel 12-like///potassium voltage-gated channel subfamily J member 18///potassium voltage-gated channel subfamily J member 12",TRUE
+"207110_at",0.536186589417525,0.0430778617779595,2.14601129841904,-3.9155259697327,1.64684059654667,"LOC100996843///KCNJ18///KCNJ12","ATP-sensitive inward rectifier potassium channel 12-like///potassium voltage-gated channel subfamily J member 18///potassium voltage-gated channel subfamily J member 12",TRUE
+"208567_s_at",0.697172073261335,0.166914868176389,1.429130499381,-4.99103614825829,1.06803324977232,"LOC100996843///KCNJ18///KCNJ12","ATP-sensitive inward rectifier potassium channel 12-like///potassium voltage-gated channel subfamily J member 18///potassium voltage-gated channel subfamily J member 12",TRUE
+"237871_x_at",0.906280556614332,0.612915772480492,0.513163710644114,-5.81222930827204,0.242761427224565,"LOC100996902","uncharacterized LOC100996902",TRUE
+"223870_at",0.835952408568777,0.415810483411436,-0.829245078671727,-5.61019349237755,-0.527675028982845,"LOC100996906///CDRT1///FBXW10","F-box/WD repeat-containing protein 10-like///CMT1A duplicated region transcript 1///F-box and WD repeat domain containing 10",TRUE
+"207979_s_at",0.610660880283135,0.0833313365851389,1.81345274183632,-4.45350922193944,0.920371952827123,"LOC100996919///CD8B","putative T-cell surface glycoprotein CD8 beta-2 chain-like///CD8b molecule",TRUE
+"1553562_at",0.917166618334994,0.649860498091082,0.460195131744326,-5.83705657701723,0.303261556588658,"LOC100996919///CD8B","putative T-cell surface glycoprotein CD8 beta-2 chain-like///CD8b molecule",TRUE
+"215332_s_at",0.954724542854807,0.794233493599432,0.263982108602376,-5.90579861231743,0.181703080859228,"LOC100996919///CD8B","putative T-cell surface glycoprotein CD8 beta-2 chain-like///CD8b molecule",TRUE
+"242954_at",0.820293495506061,0.379221336112233,-0.897270113728696,-5.55498014073834,-0.500641316906503,"LOC101059948","uncharacterized LOC101059948",TRUE
+"244372_at",0.89967769475675,0.590984910938135,-0.545314804017258,-5.79587510993824,-0.31793292122237,"LOC101060019","uncharacterized LOC101060019",TRUE
+"237075_at",0.942684843065067,0.74320284754848,0.331740372694211,-5.88622305983006,0.255991665885217,"LOC101060091","uncharacterized LOC101060091",TRUE
+"239763_at",0.617775129514679,0.0886580208367468,-1.78082308814164,-4.50287539461714,-1.21890074985304,"LOC101060179///PRDM11","uncharacterized LOC101060179///PR/SET domain 11",TRUE
+"206810_at",0.659642261650716,0.127491384496365,1.5834416044279,-4.78711162866843,0.996505249752984,"LOC101060181///ZNF44","zinc finger protein ZnFP12///zinc finger protein 44",TRUE
+"215359_x_at",0.824541923419694,0.391964684620051,0.873115507888901,-5.57504863369116,0.305334222906692,"LOC101060181///ZNF44","zinc finger protein ZnFP12///zinc finger protein 44",TRUE
+"231385_at",0.597654932724127,0.0739180744250616,-1.87581613884235,-4.3573727800041,-1.88652613257375,"LOC101060236///DPPA3P2///DPPA3","developmental pluripotency associated 3 pseudogene///developmental pluripotency associated 3 pseudogene 2///developmental pluripotency associated 3",TRUE
+"211996_s_at",0.99187501204911,0.962589824070987,0.0474371360579929,-5.93858751084771,0.0151002303270396,"LOC101060275///NPIPA5///NPIPB5///NPIPB11///LOC613037///NPIPB4///NPIPB3","putative NPIP-like protein LOC613037///nuclear pore complex interacting protein family member A5///nuclear pore complex interacting protein family member B5///nuclear pore complex interacting protein family member B11///nuclear pore complex interacting protein member///nuclear pore complex interacting protein family member B4///nuclear pore complex interacting protein family member B3",TRUE
+"226336_at",0.856148000488586,0.469567024896153,-0.735806384425734,-5.67936756158998,-0.304352758401906,"LOC101060363///PPIA","peptidyl-prolyl cis-trans isomerase A pseudogene///peptidylprolyl isomerase A",TRUE
+"212661_x_at",0.971216837324271,0.86307798663738,0.174473228041283,-5.9248677041581,0.0377230936679069,"LOC101060363///PPIA","peptidyl-prolyl cis-trans isomerase A pseudogene///peptidylprolyl isomerase A",TRUE
+"217602_at",0.974536463688956,0.875621929922563,0.158341609804136,-5.92747917511408,0.0666848895673375,"LOC101060363///PPIA","peptidyl-prolyl cis-trans isomerase A pseudogene///peptidylprolyl isomerase A",TRUE
+"201293_x_at",0.986260660718739,0.932649930336369,0.0854769348777496,-5.93612547474421,0.0184916918508833,"LOC101060363///PPIA","peptidyl-prolyl cis-trans isomerase A pseudogene///peptidylprolyl isomerase A",TRUE
+"211378_x_at",0.990810941805126,0.956796270789704,0.054790692519665,-5.93822141327104,0.0118213555706159,"LOC101060363///PPIA","peptidyl-prolyl cis-trans isomerase A pseudogene///peptidylprolyl isomerase A",TRUE
+"211978_x_at",0.994145854504594,0.973071814641045,0.0341392328897123,-5.93911583083783,0.00730239422695256,"LOC101060363///PPIA","peptidyl-prolyl cis-trans isomerase A pseudogene///peptidylprolyl isomerase A",TRUE
+"221853_s_at",0.468735421183467,0.0250827731269704,-2.40269875768488,-3.46188942344784,-0.922118136338264,"LOC101060373///NOMO3///NOMO2///NOMO1","uncharacterized LOC101060373///NODAL modulator 3///NODAL modulator 2///NODAL modulator 1",TRUE
+"217225_x_at",0.597346378847428,0.0734140003578479,-1.87934717688549,-4.3518606001291,-0.636185552669856,"LOC101060373///NOMO3///NOMO2///NOMO1","uncharacterized LOC101060373///NODAL modulator 3///NODAL modulator 2///NODAL modulator 1",TRUE
+"210057_at",0.70573152022539,0.178103866333828,1.39077895680494,-5.03908041720225,0.667621824706132,"LOC101060386///BOLA2///SMG1","putative uncharacterized SMG1-like protein///bolA family member 2///SMG1, nonsense mediated mRNA decay associated PI3K related kinase",TRUE
+"224842_at",0.9340157600858,0.707675206349776,0.379847517676681,-5.86965129805341,0.0912934462465049,"LOC101060386///BOLA2///SMG1","putative uncharacterized SMG1-like protein///bolA family member 2///SMG1, nonsense mediated mRNA decay associated PI3K related kinase",TRUE
+"237464_at",0.955515814503015,0.796193714786261,0.261406376837965,-5.9064555497272,0.0956739220541181,"LOC101060386///BOLA2///SMG1","putative uncharacterized SMG1-like protein///bolA family member 2///SMG1, nonsense mediated mRNA decay associated PI3K related kinase",TRUE
+"241535_at",0.815195559141692,0.366122030804835,0.922662468674111,-5.53333777448621,0.574820728390143,"LOC101060391","uncharacterized LOC101060391",TRUE
+"209501_at",0.689950875648652,0.159284656260225,-1.45648453023641,-4.95611569241889,-0.422439763617382,"LOC101060399///CDR2","cerebellar degeneration-related protein 2///cerebellar degeneration related protein 2",TRUE
+"243441_at",0.432506261584735,0.0194237715915057,2.52028215045607,-3.24454949029157,1.95934003419452,"LOC101060400","uncharacterized LOC101060400",TRUE
+"231250_at",0.592111379991983,0.0692782740016443,1.9091472051252,-4.30505177334933,1.3340801750122,"LOC101060400","uncharacterized LOC101060400",TRUE
+"238412_at",0.829803290928719,0.401391795329953,0.855572950854889,-5.58930462522394,0.503592748858211,"LOC101060405///RRN3P3","putative RRN3-like protein RRN3P1///RRN3 homolog, RNA polymerase I transcription factor pseudogene 3",TRUE
+"242114_at",0.704758933939989,0.176669884747718,1.39558470269286,-5.03311916959189,0.707817095420362,"LOC101060424","otoancorin-like",TRUE
+"1553432_s_at",0.861275718491431,0.481493813925088,-0.715960718320415,-5.69305234248862,-0.478382913798524,"LOC101060424///LOC653786///OTOA","otoancorin-like///otoancorin pseudogene///otoancorin",TRUE
+"229679_at",0.775341201891078,0.291924529389916,-1.07961910671156,-5.3873802022803,-0.510667723787222,"LOC101060443///C12orf76","uncharacterized LOC101060443///chromosome 12 open reading frame 76",TRUE
+"222490_at",0.571677937624457,0.0596217861131142,-1.98533304237697,-4.18307931385692,-0.753260524225141,"LOC101060521///POLR3E","DNA-directed RNA polymerase III subunit RPC5///RNA polymerase III subunit E",TRUE
+"218016_s_at",0.624520459874487,0.0961055296319955,-1.7379221352615,-4.5667808993162,-0.553226664174336,"LOC101060521///POLR3E","DNA-directed RNA polymerase III subunit RPC5///RNA polymerase III subunit E",TRUE
+"233458_at",0.951006866397403,0.776338170423691,-0.287583568530878,-5.89948134907313,-0.170711217855465,"LOC101060521///POLR3E","DNA-directed RNA polymerase III subunit RPC5///RNA polymerase III subunit E",TRUE
+"1561075_at",0.894400303187369,0.570894854703905,-0.575285554661595,-5.77976119895212,-0.198209412942433,"LOC101060553","uncharacterized LOC101060553",TRUE
+"221971_x_at",0.953042945249236,0.784693813740921,-0.276543695254315,-5.90250313163125,-0.100056327321356,"LOC101060581///AGAP5///AGAP9///AGAP12P///BMS1P5///AGAP11///AGAP4","arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5-like///ArfGAP with GTPase domain, ankyrin repeat and PH domain 5///ArfGAP with GTPase domain, ankyrin repeat and PH domain 9///ArfGAP with GTPase domain, ankyrin repeat and PH domain 12, pseudogene///BMS1, ribosome biogenesis factor pseudogene 5///ArfGAP with GTPase domain, ankyrin repeat and PH domain 11///ArfGAP with GTPase domain, ankyrin repeat and PH domain 4",TRUE
+"221850_x_at",0.94034618356165,0.733404063765332,-0.344924308570846,-5.88190177772143,-0.105005102735197,"LOC101060581///AGAP7P///AGAP12P///AGAP6///AGAP11///AGAP4","arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5-like///ArfGAP with GTPase domain, ankyrin repeat and PH domain 7, pseudogene///ArfGAP with GTPase domain, ankyrin repeat and PH domain 12, pseudogene///ArfGAP with GTPase domain, ankyrin repeat and PH domain 6///ArfGAP with GTPase domain, ankyrin repeat and PH domain 11///ArfGAP with GTPase domain, ankyrin repeat and PH domain 4",TRUE
+"231989_s_at",0.9882620262439,0.944103431381476,0.070912681798468,-5.93723452775268,0.0264299064067188,"LOC101060604///NPIPA5///SMG1P3///NPIPB5///SMG1P1///LOC613037///NPIPB4///SLC7A5P1///NPIPB3","putative L-type amino acid transporter 1-like protein IMAA///nuclear pore complex interacting protein family member A5///SMG1P3, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 3///nuclear pore complex interacting protein family member B5///SMG1P1, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 1///nuclear pore complex interacting protein member///nuclear pore complex interacting protein family member B4///solute carrier family 7 member 5 pseudogene 1///nuclear pore complex interacting protein family member B3",TRUE
+"1555216_a_at",0.73759219552868,0.22420083410442,-1.25039306141949,-5.20557425170617,-1.85817702165671,"LOC101060604///SLC7A5P2///SLC7A5P1","putative L-type amino acid transporter 1-like protein IMAA///solute carrier family 7 member 5 pseudogene 2///solute carrier family 7 member 5 pseudogene 1",TRUE
+"214984_at",0.877857073443889,0.528764165957461,0.63995543335395,-5.74215493691466,0.239882766932737,"LOC101060604///SMG1P3///SLC7A5P1","putative L-type amino acid transporter 1-like protein IMAA///SMG1P3, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 3///solute carrier family 7 member 5 pseudogene 1",TRUE
+"208118_x_at",0.93174221209471,0.698660708109804,-0.392195822355358,-5.86504105221712,-0.116771941831519,"LOC101060604///SMG1P3///SLC7A5P2///SLC7A5P1","putative L-type amino acid transporter 1-like protein IMAA///SMG1P3, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 3///solute carrier family 7 member 5 pseudogene 2///solute carrier family 7 member 5 pseudogene 1",TRUE
+"1558534_at",0.657015752622694,0.12558916914324,1.59183613559597,-4.77554445815887,0.6310396735934,"LOC101060604///SMG1P3///SMG1P1///SLC7A5P1","putative L-type amino acid transporter 1-like protein IMAA///SMG1P3, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 3///SMG1P1, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 1///solute carrier family 7 member 5 pseudogene 1",TRUE
+"1559148_at",0.878774484192636,0.53193380602017,-0.634996831772697,-5.74517491828503,-0.225527321557465,"LOC101060609","uncharacterized LOC101060609",TRUE
+"224986_s_at",0.499265335405817,0.0314242109377757,-2.29715411214355,-3.65205693070562,-0.705869876290162,"LOC101060747///PDPK1","3-phosphoinositide-dependent protein kinase 1-like///3-phosphoinositide dependent protein kinase 1",TRUE
+"244629_s_at",0.778397054392363,0.298178594293645,1.06537561408693,-5.4014769102196,0.529040904960927,"LOC101060747///PDPK1","3-phosphoinositide-dependent protein kinase 1-like///3-phosphoinositide dependent protein kinase 1",TRUE
+"244630_at",0.925389506721126,0.676836278763361,0.422355009763156,-5.85317084205769,0.248423281485,"LOC101060747///PDPK1","3-phosphoinositide-dependent protein kinase 1-like///3-phosphoinositide dependent protein kinase 1",TRUE
+"32029_at",0.927637347323107,0.682727514518186,0.414175758061504,-5.8564755406635,0.109702733304125,"LOC101060747///PDPK1","3-phosphoinositide-dependent protein kinase 1-like///3-phosphoinositide dependent protein kinase 1",TRUE
+"204524_at",0.982407245834066,0.915062712548541,0.10787888287387,-5.93401670068614,0.0340750730703778,"LOC101060747///PDPK1","3-phosphoinositide-dependent protein kinase 1-like///3-phosphoinositide dependent protein kinase 1",TRUE
+"213129_s_at",0.954577684533304,0.792700504918511,0.265997727956136,-5.90528006856434,0.104216496469267,"LOC101060817///GCSH","glycine cleavage system H protein, mitochondrial-like///glycine cleavage system protein H",TRUE
+"213133_s_at",0.994634231353802,0.975111121802329,0.0315528898866891,-5.93919857970456,0.0126090570381194,"LOC101060817///GCSH","glycine cleavage system H protein, mitochondrial-like///glycine cleavage system protein H",TRUE
+"211656_x_at",0.841550580403629,0.432865040112217,-0.798837049312022,-5.63355847111956,-0.72762253253799,"LOC101060835///HLA-DQB1","HLA class II histocompatibility antigen, DQ beta 1 chain-like///major histocompatibility complex, class II, DQ beta 1",TRUE
+"212998_x_at",0.89316156038085,0.567371603068673,-0.580596121520159,-5.77681883333009,-0.844958285219786,"LOC101060835///HLA-DQB1","HLA class II histocompatibility antigen, DQ beta 1 chain-like///major histocompatibility complex, class II, DQ beta 1",TRUE
+"209823_x_at",0.947778780715578,0.761849316677596,-0.306814691425294,-5.89393738960951,-0.314213037535517,"LOC101060835///HLA-DQB1","HLA class II histocompatibility antigen, DQ beta 1 chain-like///major histocompatibility complex, class II, DQ beta 1",TRUE
+"212999_x_at",0.993225426079816,0.968266323282088,0.0402347540418878,-5.93889503645474,0.0594801846708846,"LOC101060835///HLA-DQB1","HLA class II histocompatibility antigen, DQ beta 1 chain-like///major histocompatibility complex, class II, DQ beta 1",TRUE
+"215193_x_at",0.897949253801113,0.585864981743479,-0.552903921344736,-5.79187388020329,-0.488516653309105,"LOC101060835///LOC100996809///HLA-DRB4///HLA-DRB3///HLA-DRB1///HLA-DQB1","HLA class II histocompatibility antigen, DQ beta 1 chain-like///HLA class II histocompatibility antigen, DRB1-10 beta chain-like///major histocompatibility complex, class II, DR beta 4///major histocompatibility complex, class II, DR beta 3///major histocompatibility complex, class II, DR beta 1///major histocompatibility complex, class II, DQ beta 1",TRUE
+"209312_x_at",0.827825169467994,0.397007842132973,-0.863697453321977,-5.58273569449151,-0.758257505126405,"LOC101060835///LOC100996809///HLA-DRB5///HLA-DRB4///HLA-DRB1///HLA-DQB1","HLA class II histocompatibility antigen, DQ beta 1 chain-like///HLA class II histocompatibility antigen, DRB1-10 beta chain-like///major histocompatibility complex, class II, DR beta 5///major histocompatibility complex, class II, DR beta 4///major histocompatibility complex, class II, DR beta 1///major histocompatibility complex, class II, DQ beta 1",TRUE
+"221491_x_at",0.69910704334777,0.170432515423547,-1.41685736290097,-5.00652806140644,-0.433998599921988,"LOC101060835///LOC100996809///HLA-DRB6///HLA-DRB5///HLA-DRB4///HLA-DRB3///HLA-DRB1///HLA-DQB1","HLA class II histocompatibility antigen, DQ beta 1 chain-like///HLA class II histocompatibility antigen, DRB1-10 beta chain-like///major histocompatibility complex, class II, DR beta 6 (pseudogene)///major histocompatibility complex, class II, DR beta 5///major histocompatibility complex, class II, DR beta 4///major histocompatibility complex, class II, DR beta 3///major histocompatibility complex, class II, DR beta 1///major histocompatibility complex, class II, DQ beta 1",TRUE
+"229420_at",0.836802432816621,0.418862991522223,0.823745865748103,-5.61447957321232,0.250099543543239,"LOC101243545///SNORD4A","uncharacterized LOC101243545///small nucleolar RNA, C/D box 4A",TRUE
+"242754_at",0.918521491707893,0.654010821622099,0.454330094867842,-5.83964296718371,0.348360916444726,"LOC101559451","uncharacterized LOC101559451",TRUE
+"243272_at",0.880842449447422,0.536630575169082,-0.627678489442994,-5.74959078229629,-0.37143926900486,"LOC101593348","uncharacterized LOC101593348",TRUE
+"1556490_a_at",0.832605695407954,0.409035733440112,0.841541876997299,-5.60051291758028,0.385906485196617,"LOC101805491///TMEM247","uncharacterized LOC101805491///transmembrane protein 247",TRUE
+"1556489_at",0.872010957446544,0.514787310408206,0.662017245513836,-5.72844505280467,0.486433069824668,"LOC101805491///TMEM247","uncharacterized LOC101805491///transmembrane protein 247",TRUE
+"236156_at",0.109049446709661,0.000518660714789556,4.0571064410823,-0.0774674261981856,1.93487544992477,"LOC101926887///LIPA","uncharacterized LOC101926887///lipase A, lysosomal acid type",TRUE
+"233162_at",0.9181984176728,0.652957890764264,0.455816506522112,-5.83899055859977,0.339835808104243,"LOC101926892","uncharacterized LOC101926892",TRUE
+"230527_at",0.832792886465252,0.409736875736185,0.84026327394855,-5.60152569134027,0.740810015038559,"LOC101926907","uncharacterized LOC101926907",TRUE
+"244174_at",0.903383391791809,0.603419163068368,0.527016774960468,-5.80530129136809,0.365685970067116,"LOC101926913","uncharacterized LOC101926913",TRUE
+"215627_at",0.954759690531221,0.794349585049377,0.263829513702309,-5.90583770977311,0.216932798717604,"LOC101926913","uncharacterized LOC101926913",TRUE
+"1557841_at",0.86094046267337,0.480929924297578,0.716892488256402,-5.69241779092734,0.353457501576725,"LOC101926915","uncharacterized LOC101926915",TRUE
+"1570138_at",0.497725944448536,0.0308318969259235,2.30613889491281,-3.63605918708116,0.883809011250716,"LOC101926916","uncharacterized LOC101926916",TRUE
+"240873_x_at",0.455234810916548,0.0221426904101326,2.46030051241456,-3.35611202516116,2.20203259449022,"LOC101926921///DAB2","uncharacterized LOC101926921///DAB2, clathrin adaptor protein",TRUE
+"201278_at",0.599731655615302,0.0761123146481124,1.86068624532165,-4.38090863373596,1.9899010324908,"LOC101926921///DAB2","uncharacterized LOC101926921///DAB2, clathrin adaptor protein",TRUE
+"1559370_at",0.615637099066718,0.0861451921957318,1.79599872640513,-4.47999676818191,1.61947492130158,"LOC101926921///DAB2","uncharacterized LOC101926921///DAB2, clathrin adaptor protein",TRUE
+"210757_x_at",0.61760967235709,0.0878420736040097,1.78570970439365,-4.49552382633278,1.88045474061812,"LOC101926921///DAB2","uncharacterized LOC101926921///DAB2, clathrin adaptor protein",TRUE
+"201279_s_at",0.623667408398064,0.0951175328076556,1.74344585858221,-4.55861723620468,1.69859610541137,"LOC101926921///DAB2","uncharacterized LOC101926921///DAB2, clathrin adaptor protein",TRUE
+"201280_s_at",0.67090497764287,0.136856025892107,1.54356948858712,-4.84139694226947,2.0571433251027,"LOC101926921///DAB2","uncharacterized LOC101926921///DAB2, clathrin adaptor protein",TRUE
+"241256_at",0.952644489493803,0.783202005943709,0.278512130106482,-5.90197293946091,0.270571196490374,"LOC101926934","uncharacterized LOC101926934",TRUE
+"1570270_at",0.960614707352139,0.82120963996279,-0.228687137306762,-5.91424320078306,-0.169386377850783,"LOC101926942","uncharacterized LOC101926942",TRUE
+"229896_at",0.735341803185365,0.22029993116006,1.26135538613129,-5.19311465475755,0.865325111886807,"LOC101926943","uncharacterized LOC101926943",TRUE
+"1557802_at",0.908667507590078,0.620259909279184,-0.502519993587007,-5.81743007317551,-0.44555434448112,"LOC101926944","uncharacterized LOC101926944",TRUE
+"1563089_at",0.929972194057784,0.690677371634474,0.403183621272645,-5.86081660274242,0.223804516907023,"LOC101926948","uncharacterized LOC101926948",TRUE
+"1560566_at",0.448873991611994,0.0213750428858883,-2.47650833388656,-3.32610604809644,-1.51598001068085,"LOC101926951///PCDH20","uncharacterized LOC101926951///protocadherin 20",TRUE
+"232054_at",0.913300726876965,0.636550616963319,-0.479116368929788,-5.82849119321002,-0.506969774218708,"LOC101926951///PCDH20","uncharacterized LOC101926951///protocadherin 20",TRUE
+"1560850_at",0.744931128252932,0.236683344497147,-1.21626402639321,-5.24376479146631,-1.71853431651597,"LOC101926959","uncharacterized LOC101926959",TRUE
+"1557832_at",0.886560514511744,0.549432400067964,0.607903550014425,-5.76127621430003,0.413028693978989,"LOC101926960","uncharacterized LOC101926960",TRUE
+"1561104_at",0.567292616148537,0.0572308205041602,2.00587673869198,-4.14963595896544,1.31519809869891,"LOC101926962","uncharacterized LOC101926962",TRUE
+"229972_at",0.767727587789514,0.269809393713045,1.13182490745308,-5.33428985514164,0.623256539609819,"LOC101926963","uncharacterized LOC101926963",TRUE
+"236668_at",0.620223198657182,0.0900033386900862,-1.7728500358002,-4.51483867316128,-0.771263351975322,"LOC101926967","uncharacterized LOC101926967",TRUE
+"1564083_at",0.88113080359582,0.537383386962815,-0.626508697669522,-5.75029206384815,-0.39126448559336,"LOC101926975","uncharacterized LOC101926975",TRUE
+"1562408_at",0.909052380289506,0.622518663420768,0.499258274531827,-5.81900253220309,0.200675292160741,"LOC101926984","leucine-rich repeat-containing protein 37A3",TRUE
+"1562409_s_at",0.966343301904459,0.843100286921747,-0.200264765498187,-5.92016819598993,-0.103978078331374,"LOC101926984","leucine-rich repeat-containing protein 37A3",TRUE
+"216772_at",0.710672261019989,0.183880404572515,1.37172575984584,-5.06254693725616,0.908267247142153,"LOC101926997","uncharacterized LOC101926997",TRUE
+"216771_at",0.907111393934291,0.615678849727482,0.509152252143516,-5.81420188267919,0.251505242887617,"LOC101926997","uncharacterized LOC101926997",TRUE
+"1563241_at",0.65523332696065,0.123889537791039,1.59942668952782,-4.76504410460786,1.37811907976146,"LOC101927018","uncharacterized LOC101927018",TRUE
+"240842_at",0.728385463227073,0.209479008632151,1.29256535795406,-5.15713348841877,0.549248366134558,"LOC101927020","uncharacterized LOC101927020",TRUE
+"241847_at",0.475332226369346,0.0262598537117417,2.38137564755223,-3.50069679690219,0.906450995026928,"LOC101927021","uncharacterized LOC101927021",TRUE
+"235813_at",0.806341956816164,0.34726379689616,0.960307334536084,-5.50023128168838,0.857610080253821,"LOC101927027","uncharacterized LOC101927027",TRUE
+"228714_at",0.829803290928719,0.401548115331886,0.855284308231493,-5.58953693887766,0.930374015528622,"LOC101927027","uncharacterized LOC101927027",TRUE
+"228620_at",0.839519981963042,0.42812352168407,0.807214936717579,-5.62720279286843,0.930036448315843,"LOC101927027","uncharacterized LOC101927027",TRUE
+"237105_at",0.955904644595647,0.800260072564804,0.256068915518766,-5.90779649210795,0.227207720495708,"LOC101927027","uncharacterized LOC101927027",TRUE
+"243035_at",0.731548533938014,0.214934065971347,1.27668043770782,-5.1755405358402,0.541162096690133,"LOC101927038","uncharacterized LOC101927038",TRUE
+"1562621_at",0.421194407365884,0.0175256932191566,2.56699312737918,-3.15671110151393,1.29367266533387,"LOC101927040","uncharacterized LOC101927040",TRUE
+"237501_at",0.772700799794446,0.283189366735823,1.09988504940931,-5.36703535760785,0.555393254915947,"LOC101927043","uncharacterized LOC101927043",TRUE
+"1562604_at",0.943988850936011,0.749170231457588,0.323740888377496,-5.88876382105268,0.238037355372126,"LOC101927043","uncharacterized LOC101927043",TRUE
+"1562759_at",0.798136642075741,0.332360308473039,0.991052491263237,-5.47229558139453,0.581371201280327,"LOC101927044","uncharacterized LOC101927044",TRUE
+"215799_at",0.702324656770028,0.173744224048673,1.40548675048532,-5.02078272123353,0.5475379938759,"LOC101927051","uncharacterized LOC101927051",TRUE
+"1561419_at",0.85006583881333,0.452606614242247,-0.764548858531328,-5.65891924070106,-0.409280642520108,"LOC101927051","uncharacterized LOC101927051",TRUE
+"1561420_a_at",0.943512938262733,0.747412911485002,-0.326094375088971,-5.88802268950152,-0.163171509526774,"LOC101927051","uncharacterized LOC101927051",TRUE
+"238720_at",0.696129677967645,0.166167705690976,1.43176404972938,-4.98769765425978,0.882739076839914,"LOC101927057///OMG","uncharacterized LOC101927057///oligodendrocyte myelin glycoprotein",TRUE
+"207093_s_at",0.99886461451188,0.995028097473974,0.00630208303035663,-5.9396641364463,0.00222641979213645,"LOC101927057///OMG","uncharacterized LOC101927057///oligodendrocyte myelin glycoprotein",TRUE
+"1561544_at",0.638101654979046,0.109265859781826,1.66861184430463,-4.66756513207844,1.03765664485689,"LOC101927058","uncharacterized LOC101927058",TRUE
+"1563170_at",0.528235927681883,0.0408599822019651,2.17164500260147,-3.87161515534544,1.10003123500335,"LOC101927059","uncharacterized LOC101927059",TRUE
+"236803_at",0.895457620469779,0.574360550320188,0.570077991645948,-5.78262106167735,0.461932870682213,"LOC101927060","uncharacterized LOC101927060",TRUE
+"1560182_at",0.928295253101366,0.685418918476491,0.410448651864898,-5.85796033855467,0.338096912836479,"LOC101927066","uncharacterized LOC101927066",TRUE
+"1560169_at",0.897699110987203,0.584997525682556,0.554192971852886,-5.79118891569326,0.604102709157993,"LOC101927069","uncharacterized LOC101927069",TRUE
+"1563019_at",0.88767000285873,0.55236169732846,-0.603413098867712,-5.76387944954626,-0.368573855230526,"LOC101927071","uncharacterized LOC101927071",TRUE
+"1564856_s_at",0.772430642757484,0.282908197128919,1.1005448298183,-5.36636734870068,0.584785931607664,"LOC101927079///LOC727924","uncharacterized LOC101927079///uncharacterized LOC727924",TRUE
+"1564855_at",0.905934790589647,0.61237223482417,0.513953825982412,-5.8118390018164,0.569549164894925,"LOC101927079///LOC727924","uncharacterized LOC101927079///uncharacterized LOC727924",TRUE
+"1560734_at",0.933548873991014,0.705822806389721,0.382380017545525,-5.86871763922674,0.481157375707821,"LOC101927079///LOC727924///OR4N4","uncharacterized LOC101927079///uncharacterized LOC727924///olfactory receptor family 4 subfamily N member 4",TRUE
+"236627_at",0.981217921631328,0.911388585864204,0.112565607814176,-5.93351377986864,0.0858200008359375,"LOC101927085","uncharacterized LOC101927085",TRUE
+"236271_at",0.998347572104896,0.993190914672207,-0.00863083715002035,-5.93964719882415,-0.00778126230504839,"LOC101927085","uncharacterized LOC101927085",TRUE
+"216489_at",0.716472449896956,0.192453053316144,1.3443042752465,-5.09584632024803,0.814206814663981,"LOC101927086","uncharacterized LOC101927086",TRUE
+"240880_at",0.99443717604727,0.974430209542433,-0.032416428664605,-5.93917167567033,-0.0216274940514278,"LOC101927089","uncharacterized LOC101927089",TRUE
+"237576_x_at",0.171054203824867,0.00145785364981777,3.63276582013113,-0.988850888309247,1.73017663340459,"LOC101927093","uncharacterized LOC101927093",TRUE
+"1562965_at",0.944850801239076,0.751997967560783,-0.319957754847142,-5.88994402171134,-0.183156623312675,"LOC101927095","uncharacterized LOC101927095",TRUE
+"237883_at",0.955527140391899,0.796328332850419,-0.261229555116164,-5.90650041318841,-0.0935941526664656,"LOC101927098","uncharacterized LOC101927098",TRUE
+"1560352_at",0.739340500562926,0.226808796652715,1.24314520434808,-5.21376075630376,0.736001403065962,"LOC101927104///ENTPD1-AS1","uncharacterized LOC101927104///ENTPD1 antisense RNA 1",TRUE
+"232502_at",0.820293495506061,0.379284956317863,0.897148214065618,-5.55508269228547,0.594500576098247,"LOC101927104///ENTPD1-AS1","uncharacterized LOC101927104///ENTPD1 antisense RNA 1",TRUE
+"1555222_a_at",0.797856706388872,0.33175682092519,0.992317241311253,-5.47112924132306,0.263355168817441,"LOC101927122","uncharacterized LOC101927122",TRUE
+"1555221_at",0.848268984089208,0.447942094026067,0.77256681866088,-5.65308286512399,0.532831604593512,"LOC101927122","uncharacterized LOC101927122",TRUE
+"1570292_at",0.888830748858811,0.556100407179271,-0.59769996516914,-5.76716456643991,-0.386705355782067,"LOC101927123","uncharacterized LOC101927123",TRUE
+"1570226_at",0.519956259865057,0.0375019960742778,2.21296232486856,-3.80016094388037,1.92880580787119,"LOC101927124","uncharacterized LOC101927124",TRUE
+"1569767_at",0.989524702314661,0.948874637744269,-0.0648504428873347,-5.93763530539892,-0.0350450973777301,"LOC101927131","uncharacterized LOC101927131",TRUE
+"241594_at",0.803487298448767,0.341528025897564,0.972030930180055,-5.48967368507194,0.798487953884041,"LOC101927133","uncharacterized LOC101927133",TRUE
+"214432_at",0.799620029216834,0.335087226509668,-0.985357264713641,-5.47753090023297,-0.313894787330717,"LOC101927137///ATP1A3","uncharacterized LOC101927137///ATPase Na+/K+ transporting subunit alpha 3",TRUE
+"200910_at",0.874305976196739,0.520166968604015,-0.653487152194087,-5.73379878748962,-0.161478876054305,"LOC101927137///CCT3","uncharacterized LOC101927137///chaperonin containing TCP1 subunit 3",TRUE
+"227002_at",0.801086839730802,0.337440833534692,-0.980467311210596,-5.48200406009268,-1.04620176124601,"LOC101927137///FAM78A","uncharacterized LOC101927137///family with sequence similarity 78 member A",TRUE
+"1558541_at",0.847579833261406,0.446433567518102,-0.775170692732624,-5.65117510793101,-0.6812488676269,"LOC101927137///KIAA1456","uncharacterized LOC101927137///KIAA1456",TRUE
+"214796_at",0.860714927752408,0.480573302847506,0.717482097020187,-5.69201585141911,0.408151523147946,"LOC101927137///KIAA1456","uncharacterized LOC101927137///KIAA1456",TRUE
+"239297_at",0.930686774664133,0.693023110691781,-0.399949900719605,-5.86207179841848,-0.288065973109421,"LOC101927137///KIAA1456","uncharacterized LOC101927137///KIAA1456",TRUE
+"1569495_at",0.841263442969847,0.431517755063363,0.801211783455088,-5.63176326472636,0.584611482115258,"LOC101927137///SCLT1","uncharacterized LOC101927137///sodium channel and clathrin linker 1",TRUE
+"1569190_at",0.919378883093968,0.657429468538178,0.4495111626058,-5.84174370293547,0.248392974047625,"LOC101927137///SCLT1","uncharacterized LOC101927137///sodium channel and clathrin linker 1",TRUE
+"236487_at",0.927973182663162,0.683873462449999,0.412588101663335,-5.85710964261917,0.119980284604432,"LOC101927137///SCLT1","uncharacterized LOC101927137///sodium channel and clathrin linker 1",TRUE
+"1556921_at",0.977874971442423,0.893100520209307,-0.135934538460255,-5.93068743705453,-0.102710262929099,"LOC101927138","uncharacterized LOC101927138",TRUE
+"1560560_at",0.841550580403629,0.432934611972624,0.798714545743674,-5.63365094317221,0.328427146543542,"LOC101927143","uncharacterized LOC101927143",TRUE
+"206833_s_at",0.826088985184893,0.393652516708348,0.86995481504412,-5.57763704468523,0.350331745032214,"LOC101927144///ACYP2","uncharacterized LOC101927144///acylphosphatase 2",TRUE
+"1569478_s_at",0.774230543658252,0.287057593252978,1.09085576997433,-5.3761414251288,0.715207227282415,"LOC101927151","uncharacterized LOC101927151",TRUE
+"235322_at",0.819018525257656,0.374615289303883,0.906131570188919,-5.54749069492096,0.528066791211176,"LOC101927151","uncharacterized LOC101927151",TRUE
+"1562792_at",0.948015976270656,0.763888820180328,-0.30410066640248,-5.89474134298081,-0.0942835376236886,"LOC101927157","uncharacterized LOC101927157",TRUE
+"232158_x_at",0.227168192678334,0.00284693590926149,3.35434955311924,-1.57757594469807,1.22400315561184,"LOC101927157///NIPAL1","uncharacterized LOC101927157///NIPA like domain containing 1",TRUE
+"1562052_at",0.934048461921637,0.707778600660265,0.379706237297965,-5.86970320383129,0.211300846872673,"LOC101927159","uncharacterized LOC101927159",TRUE
+"1561530_at",0.909098669732994,0.623010855270735,0.498548261529234,-5.81934350128805,0.295018618186921,"LOC101927164","uncharacterized LOC101927164",TRUE
+"1562310_at",0.989400498103458,0.947713793781965,-0.0663251595185348,-5.93754110410873,-0.065417942942541,"LOC101927165","uncharacterized LOC101927165",TRUE
+"1561346_at",0.7717895132349,0.281499913245419,1.10385661568786,-5.36300888149513,0.664506741411731,"LOC101927166","uncharacterized LOC101927166",TRUE
+"1561347_a_at",0.874834820370747,0.521451255752058,0.651457972559253,-5.73506255172119,0.555038314998487,"LOC101927166","uncharacterized LOC101927166",TRUE
+"227029_at",0.519956259865057,0.0375687662208095,-2.21210859491957,-3.80164572135271,-0.90800158579567,"LOC101927178///FAM177A1","uncharacterized LOC101927178///family with sequence similarity 177 member A1",TRUE
+"201527_at",0.9089753392553,0.621788915413022,-0.500311454039802,-5.81849589204198,-0.132601532828531,"LOC101927180///ATP6V1F","V-type proton ATPase subunit F pseudogene///ATPase H+ transporting V1 subunit F",TRUE
+"216455_at",0.861962516141708,0.484583127505667,-0.710867160747233,-5.69650725824367,-0.41172863766345,"LOC101927181","uncharacterized LOC101927181",TRUE
+"216460_at",0.93565329131222,0.713344541394549,-0.372112323790547,-5.87246514575351,-0.239493377405425,"LOC101927181","uncharacterized LOC101927181",TRUE
+"1560288_at",0.931121627074226,0.695045714387144,0.397165119873223,-5.86314475780953,0.379147540152966,"LOC101927196","uncharacterized LOC101927196",TRUE
+"235152_at",0.841967750949524,0.434690308169134,0.795627099062227,-5.63597710478237,0.303041151471296,"LOC101927204","uncharacterized LOC101927204",TRUE
+"244749_at",0.91876780831279,0.654909782374638,0.453061863383514,-5.84019796164092,0.21151542636714,"LOC101927204","uncharacterized LOC101927204",TRUE
+"1559617_at",0.91671872326659,0.647888277039308,0.462987921227792,-5.83581357669709,0.333876680052739,"LOC101927206","uncharacterized LOC101927206",TRUE
+"1562950_at",0.94632739401154,0.757114416866063,0.313124675151305,-5.89204087862145,0.132442008857767,"LOC101927210","uncharacterized LOC101927210",TRUE
+"1561033_at",0.430788360707443,0.0191067539957119,2.52777850370363,-3.23050840452288,1.90216006377375,"LOC101927211","uncharacterized LOC101927211",TRUE
+"1561224_at",0.937271400689562,0.721994688300728,0.360354357296465,-5.87663292752122,0.271918093433882,"LOC101927228","uncharacterized LOC101927228",TRUE
+"1559621_at",0.980001024522674,0.905060242558289,0.120644178881975,-5.93259675375299,0.104180312370261,"LOC101927237","uncharacterized LOC101927237",TRUE
+"1562046_at",0.983136574792668,0.917935855447626,-0.104215624099474,-5.93439492274351,-0.0942869605392858,"LOC101927244","uncharacterized LOC101927244",TRUE
+"1563283_at",0.715352956634026,0.191012961132866,1.34884254947371,-5.09037407079712,0.692772994155662,"LOC101927247","uncharacterized LOC101927247",TRUE
+"239634_at",0.932830928398943,0.703632498505529,-0.385377777054587,-5.86760454700739,-0.211975890081129,"LOC101927248","uncharacterized LOC101927248",TRUE
+"1559948_at",0.953983577550391,0.787962025545526,0.272235187748709,-5.90365058728524,0.190943213696016,"LOC101927253","uncharacterized LOC101927253",TRUE
+"232634_at",0.912329443373872,0.632798710216138,0.484481969793102,-5.82600082137503,0.320664028313765,"LOC101927254","uncharacterized LOC101927254",TRUE
+"1568730_at",0.797127506889432,0.330307149937961,0.995361877502211,-5.46831596436036,0.763894444827585,"LOC101927256","uncharacterized LOC101927256",TRUE
+"1564338_at",0.904832003218088,0.609840634220027,-0.517638276192135,-5.81001120439206,-0.302300288622137,"LOC101927257","uncharacterized LOC101927257",TRUE
+"236396_at",0.700061364939874,0.171680960293347,1.41255030240543,-5.01193868529939,1.06210301242517,"LOC101927263","uncharacterized LOC101927263",TRUE
+"220744_s_at",0.841066968594092,0.430770888368365,-0.802530195018317,-5.63076443515333,-0.651263115456471,"LOC101927266///IFT122","intraflagellar transport protein 122 homolog///intraflagellar transport 122",TRUE
+"232384_s_at",0.832605695407954,0.409358849194432,0.84095247014421,-5.60097996184912,0.690584243085877,"LOC101927272","uncharacterized LOC101927272",TRUE
+"1569805_at",0.788758616802423,0.314984099483568,-1.02812646665608,-5.43754718595739,-0.578079699570441,"LOC101927274","uncharacterized LOC101927274",TRUE
+"238979_at",0.988224361618126,0.943964538222482,-0.071089197486669,-5.93722232220856,-0.0298636121434988,"LOC101927278","uncharacterized LOC101927278",TRUE
+"1557753_at",0.803988341675731,0.342652699364022,0.969721627990943,-5.4917625617117,0.622040378907418,"LOC101927282","uncharacterized LOC101927282",TRUE
+"1562720_at",0.892178923218045,0.564398254228713,0.585090971506835,-5.77430797528954,0.349438115890874,"LOC101927286","uncharacterized LOC101927286",TRUE
+"1569756_at",0.789661545166663,0.317389101134573,1.02291138847507,-5.4425049009484,0.873218415354672,"LOC101927292","uncharacterized LOC101927292",TRUE
+"237770_at",0.757361197594703,0.253272396992964,-1.17294949562611,-5.29091251835373,-1.3380373658698,"LOC101927305","uncharacterized LOC101927305",TRUE
+"237771_s_at",0.971826767527606,0.865093448188346,0.171878244108252,-5.92530483310379,0.204527747457712,"LOC101927305","uncharacterized LOC101927305",TRUE
+"1556687_a_at",0.712975827977365,0.187238562410977,1.36086621503817,-5.07580139386037,1.08539551313456,"LOC101927308///CLDN10","uncharacterized LOC101927308///claudin 10",TRUE
+"1561513_at",0.897745289225875,0.585410384943212,-0.553579339595879,-5.79151517542076,-0.334424266508699,"LOC101927310","uncharacterized LOC101927310",TRUE
+"1563064_at",0.899808883319249,0.59200210703087,-0.543810907799349,-5.7966616345482,-0.269425240388993,"LOC101927313","uncharacterized LOC101927313",TRUE
+"1556832_at",0.594566152840757,0.0713600915837602,-1.89395757025483,-4.32897547924097,-1.70069925084874,"LOC101927314","uncharacterized LOC101927314",TRUE
+"235825_at",0.544172907409316,0.0464545562865316,-2.10918429041402,-3.97803528545067,-1.59980145866453,"LOC101927330","uncharacterized LOC101927330",TRUE
+"1563298_at",0.859465912277024,0.476555894490258,0.724141859487048,-5.68745403367437,0.547331829321663,"LOC101927331","uncharacterized LOC101927331",TRUE
+"243435_at",0.67565343307767,0.142236324000439,1.52167021156363,-4.87074640987115,0.974154494515377,"LOC101927338///KCNQ1OT1","uncharacterized LOC101927338///KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)",TRUE
+"237249_at",0.718943521687533,0.194928718915346,1.33656446750457,-5.10514329160267,0.892510875923782,"LOC101927338///KCNQ1OT1","uncharacterized LOC101927338///KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)",TRUE
+"243428_at",0.80056683899707,0.336537216665549,-0.982341921740131,-5.48029162653505,-0.836805606059803,"LOC101927338///KCNQ1OT1","uncharacterized LOC101927338///KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)",TRUE
+"204486_at",0.842917136850585,0.436772346617607,0.791975727218442,-5.63871720353736,0.651617560385399,"LOC101927338///KCNQ1OT1","uncharacterized LOC101927338///KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)",TRUE
+"244727_at",0.959203345279235,0.815120320265198,-0.236626724634081,-5.91244847921777,-0.142621430715516,"LOC101927338///KCNQ1OT1","uncharacterized LOC101927338///KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)",TRUE
+"1569732_at",0.769847953580141,0.277421518947542,1.11351589736799,-5.35316229047814,0.481522589461516,"LOC101927339","uncharacterized LOC101927339",TRUE
+"244437_at",0.699181208035307,0.170650767742544,1.41610258812107,-5.00747720450723,0.854311721998315,"LOC101927340","uncharacterized LOC101927340",TRUE
+"241290_at",0.597125847323965,0.0731622505939322,1.88111862237129,-4.34909251108668,1.25645714640294,"LOC101927342","uncharacterized LOC101927342",TRUE
+"237737_at",0.962555471240652,0.829690957930728,0.217653607502036,-5.9166360987441,0.203110267403649,"LOC101927345///LOC101060632///LOC101059949///ANKRD20A12P","putative ankyrin repeat domain-containing protein 20A12 pseudogene///uncharacterized gene LOC101060632///putative ankyrin repeat domain-containing protein 20A12 pseudogene///ankyrin repeat domain 20 family member A12, pseudogene",TRUE
+"1561519_at",0.919691066792211,0.658561041718918,0.447918478649288,-5.84243317787726,0.389396658569416,"LOC101927346","uncharacterized LOC101927346",TRUE
+"1568908_at",0.761748280722165,0.261180493772461,1.15304352410609,-5.31207877300068,0.550973734442517,"LOC101927348","uncharacterized LOC101927348",TRUE
+"1562541_at",0.940227139261806,0.732219302206626,0.346522550269926,-5.88136660881942,0.244561914219691,"LOC101927354","uncharacterized LOC101927354",TRUE
+"1569858_at",0.771159692311272,0.28029633981523,-1.10669653029879,-5.36012179847681,-0.491156078776427,"LOC101927358","uncharacterized LOC101927358",TRUE
+"1562389_at",0.988065316951061,0.942987580304295,-0.0723308535131016,-5.93713560829433,-0.0786249714915366,"LOC101927359","uncharacterized LOC101927359",TRUE
+"1563250_at",0.774421352016308,0.290723435667517,1.0823795600819,-5.3846288487161,0.271506412890941,"LOC101927362","uncharacterized LOC101927362",TRUE
+"1563116_at",0.843166862470942,0.437614011089857,-0.790502702685969,-5.6398192475259,-0.461283199959355,"LOC101927363","uncharacterized LOC101927363",TRUE
+"232261_at",0.80056683899707,0.336483653250433,0.98245315100227,-5.48018992635923,0.972543728341966,"LOC101927365","uncharacterized LOC101927365",TRUE
+"238069_at",0.974451535839172,0.875126096255601,-0.158978411544013,-5.92738087357568,-0.0885725314131394,"LOC101927365","uncharacterized LOC101927365",TRUE
+"1558571_at",0.730048787941067,0.212382365490144,1.28407166700573,-5.16699987013247,0.495168470612354,"LOC101927377","uncharacterized LOC101927377",TRUE
+"243814_at",0.982243328340126,0.91472221513701,-0.108313116504603,-5.93397100199127,-0.0417001030190214,"LOC101927377","uncharacterized LOC101927377",TRUE
+"1562801_at",0.950089610703332,0.773260861210564,0.291658595106625,-5.89833630272726,0.173728947200802,"LOC101927379","uncharacterized LOC101927379",TRUE
+"244524_at",0.724970327905974,0.202918559174271,1.31209905814119,-5.13423359098412,1.26112689150873,"LOC101927382///PAX8-AS1","uncharacterized LOC101927382///PAX8 antisense RNA 1",TRUE
+"244116_at",0.899808883319249,0.592020821427052,-0.54378325097432,-5.79667607905999,-0.500593566164924,"LOC101927391","uncharacterized LOC101927391",TRUE
+"238559_at",0.900277982211162,0.595157990889238,0.539153062565757,-5.799084250519,0.32201447267416,"LOC101927402","uncharacterized LOC101927402",TRUE
+"1563027_at",0.739189560382301,0.226256381838675,1.2446751071166,-5.21203612685139,0.953650702374481,"LOC101927406","uncharacterized LOC101927406",TRUE
+"1565775_at",0.789927874973432,0.319089300937552,1.0192413119715,-5.44598020409274,0.623263179907432,"LOC101927410","uncharacterized LOC101927410",TRUE
+"1570013_at",0.666643938027574,0.133408372679736,-1.55797823697025,-4.82190536512179,-0.87556683584659,"LOC101927411","uncharacterized LOC101927411",TRUE
+"1559333_at",0.812896635201594,0.361934257432045,0.930907466825905,-5.52619076358577,0.829383227778331,"LOC101927416","uncharacterized LOC101927416",TRUE
+"240075_at",0.562850785881581,0.0553740169594335,2.02236365557193,-4.12263043174379,0.924370387134158,"LOC101927417","uncharacterized LOC101927417",TRUE
+"236282_at",0.76912869907427,0.274574117998977,-1.12032112230932,-5.34617944912955,-0.309262977940266,"LOC101927420","uncharacterized LOC101927420",TRUE
+"1560132_a_at",0.985236747758359,0.926527990114157,-0.0932691540607038,-5.93544734081414,-0.0673035623054643,"LOC101927432","uncharacterized LOC101927432",TRUE
+"1559787_at",0.876632890672003,0.525532295261659,0.645028070220799,-5.73904214309429,0.454224373008967,"LOC101927438","uncharacterized LOC101927438",TRUE
+"234311_s_at",0.913169843988782,0.635704347604898,0.480325367346173,-5.82793241985017,0.13927882864575,"LOC101927446///GTPBP10","uncharacterized LOC101927446///GTP binding protein 10",TRUE
+"239773_at",0.957174671135192,0.806203454505108,0.248281297096882,-5.90970367548695,0.0722719740357647,"LOC101927446///GTPBP10","uncharacterized LOC101927446///GTP binding protein 10",TRUE
+"230684_at",0.970161937857351,0.858320498546608,-0.180603576861016,-5.9238091009707,-0.169670134694091,"LOC101927446///GTPBP10","uncharacterized LOC101927446///GTP binding protein 10",TRUE
+"216619_at",0.973071267819624,0.869806496114435,0.165814694134474,-5.92630078323753,0.159779678141626,"LOC101927446///GTPBP10","uncharacterized LOC101927446///GTP binding protein 10",TRUE
+"1562655_at",0.390155580909671,0.012984995907035,2.70152637717616,-2.89932711587379,1.4375204365344,"LOC101927447","uncharacterized LOC101927447",TRUE
+"1561322_at",0.987824325922526,0.941933630214374,0.0736704927854906,-5.93704036850233,0.0714514068225718,"LOC101927450","uncharacterized LOC101927450",TRUE
+"241388_at",0.842917136850585,0.436760337242805,0.791996757854241,-5.63870145547664,0.264234179377176,"LOC101927451","uncharacterized LOC101927451",TRUE
+"1562934_at",0.51470556386048,0.0352770031922184,2.24223316397621,-3.74904461212113,1.39659221552022,"LOC101927460","uncharacterized LOC101927460",TRUE
+"1562797_at",0.961644868810744,0.826188484306385,-0.222206622497943,-5.91566293153123,-0.0659503204900247,"LOC101927467","uncharacterized LOC101927467",TRUE
+"240648_at",0.969891556938326,0.857440187901126,0.181738687189441,-5.9236090891213,0.0893832425539216,"LOC101927478","uncharacterized LOC101927478",TRUE
+"236601_at",0.860994442844737,0.481070064186792,0.716660862080631,-5.69257560573337,0.475183703659643,"LOC101927479","uncharacterized LOC101927479",TRUE
+"232397_at",0.961212424803935,0.823244810934596,-0.226036943765877,-5.91482870478773,-0.236531703531981,"LOC101927482","uncharacterized LOC101927482",TRUE
+"1560848_at",0.901201392777064,0.59778456171643,0.535285627177597,-5.80108036447213,0.383972320220515,"LOC101927490","uncharacterized LOC101927490",TRUE
+"1561525_at",0.723631474020681,0.20005295185695,1.32078577214652,-5.12395662853988,1.19012744732159,"LOC101927494","uncharacterized LOC101927494",TRUE
+"1562029_at",0.547343369043481,0.047937737229423,2.09376500725065,-4.00400264930676,1.43232630213538,"LOC101927495","uncharacterized LOC101927495",TRUE
+"238249_at",0.897024165042344,0.582828193219794,0.557420793128416,-5.7894669516208,0.42488588824451,"LOC101927499","uncharacterized LOC101927499",TRUE
+"1562895_at",0.843950128127185,0.440118040494715,0.786130588253307,-5.6430788709038,0.566754877828497,"LOC101927502","uncharacterized LOC101927502",TRUE
+"231278_at",0.959659304380916,0.818049221751831,-0.232805954033386,-5.91331975891466,-0.107743262241798,"LOC101927503","uncharacterized LOC101927503",TRUE
+"244379_at",0.742286839825305,0.232662493638589,1.22710521971182,-5.23173227592507,1.17949431948896,"LOC101927507","uncharacterized LOC101927507",TRUE
+"1563162_at",0.948109877411639,0.764323785807801,0.303522147534019,-5.89491179749996,0.129025322992195,"LOC101927508","uncharacterized LOC101927508",TRUE
+"1562915_at",0.792436690618566,0.324004109578346,1.00870840701526,-5.45589135435313,0.372730574813319,"LOC101927513","uncharacterized LOC101927513",TRUE
+"1556171_a_at",0.778291838199375,0.297789193091856,-1.06625619433215,-5.40061026307269,-0.707426610806,"LOC101927516","uncharacterized LOC101927516",TRUE
+"1556170_at",0.943988850936011,0.749846015598922,-0.322836343098717,-5.88904725575725,-0.305725010410005,"LOC101927516","uncharacterized LOC101927516",TRUE
+"1561573_at",0.698391916012681,0.169330450827476,-1.42068046276963,-5.00171406339016,-1.13057175341359,"LOC101927523","uncharacterized LOC101927523",TRUE
+"1563247_at",0.824027323790285,0.391433701938387,-0.874111668148298,-5.57423103325852,-0.534348527122405,"LOC101927526","uncharacterized LOC101927526",TRUE
+"1556362_at",0.916790160854655,0.648342940819333,0.462343757809457,-5.8361009312911,0.193049268786095,"LOC101927531","uncharacterized LOC101927531",TRUE
+"1569900_at",0.733239804133891,0.217679772771482,-1.26880235693424,-5.18459744035022,-0.921572679775259,"LOC101927533///LOC440867","uncharacterized LOC101927533///uncharacterized LOC440867",TRUE
+"1563302_at",0.988391891288248,0.944508492550293,-0.0703979133011547,-5.93726994929383,-0.0252760396507625,"LOC101927534","uncharacterized LOC101927534",TRUE
+"1561624_at",0.895999830738594,0.576977190679021,0.566156751988878,-5.78475787371079,0.159773212605426,"LOC101927537","uncharacterized LOC101927537",TRUE
+"1570182_at",0.895457620469779,0.574501058388516,-0.569867200332875,-5.78273629233198,-0.427062452829532,"LOC101927539","uncharacterized LOC101927539",TRUE
+"1560449_at",0.867580082241907,0.500247705637115,0.685323448971703,-5.71347849547321,0.531983718543985,"LOC101927543","uncharacterized LOC101927543",TRUE
+"220687_at",0.708473702007515,0.180438528448724,1.38302015143121,-5.04866881977025,0.843494674406206,"LOC101927550","uncharacterized LOC101927550",TRUE
+"237845_at",0.939676168830753,0.729424827768798,0.350295948559222,-5.8800933900371,0.312760806820463,"LOC101927552","uncharacterized LOC101927552",TRUE
+"1563391_at",0.83030603167465,0.402158881994657,0.854157226827079,-5.59044336957383,0.288528433400964,"LOC101927553","uncharacterized LOC101927553",TRUE
+"206374_at",0.595453032706696,0.0721792243011158,-1.88808714989368,-4.33818560361921,-0.921659543424224,"LOC101927562///DUSP8","uncharacterized LOC101927562///dual specificity phosphatase 8",TRUE
+"238594_x_at",0.654341146398909,0.123352431567143,-1.60184345640032,-4.76169273009159,-0.705099863688203,"LOC101927562///DUSP8","uncharacterized LOC101927562///dual specificity phosphatase 8",TRUE
+"1562065_at",0.552420073963858,0.050147266929872,2.07157054047835,-4.041164277803,0.785502137128731,"LOC101927582","uncharacterized LOC101927582",TRUE
+"1562341_at",0.951893068371814,0.779628075283344,0.283232510024735,-5.90068631313929,0.193741973724455,"LOC101927587///LOC101927560","uncharacterized LOC101927587///uncharacterized LOC101927560",TRUE
+"1564721_at",0.986342822130003,0.933345594519436,0.0845918214585448,-5.93619876687965,0.0529884399827525,"LOC101927588","uncharacterized LOC101927588",TRUE
+"1561528_at",0.768852835478002,0.272775674798359,1.12464593773287,-5.34172218715635,0.849601798052871,"LOC101927592","uncharacterized LOC101927592",TRUE
+"239560_at",0.886567073863495,0.549492205797559,0.607811745316479,-5.76132962246217,0.20410903362967,"LOC101927603","uncharacterized LOC101927603",TRUE
+"1557702_at",0.636147339487472,0.107636013490601,-1.676798031502,-4.65582264943082,-0.799409086200892,"LOC101927604","uncharacterized LOC101927604",TRUE
+"1562222_at",0.54295328972902,0.0458014761864268,-2.11611454753728,-3.96632449723543,-0.642048931592722,"LOC101927606","uncharacterized LOC101927606",TRUE
+"1564878_at",0.982884736081404,0.916714848670618,0.105772226934046,-5.9342358020995,0.0396414806083483,"LOC101927606","uncharacterized LOC101927606",TRUE
+"242386_x_at",0.951934441578502,0.780037041682983,0.282692023888788,-5.90083472040071,0.141391535772804,"LOC101927608","uncharacterized LOC101927608",TRUE
+"239775_at",0.877948371309952,0.529638579635904,0.638585887552037,-5.74299130109164,0.354540064800528,"LOC101927609","uncharacterized LOC101927609",TRUE
+"1563539_at",0.789595899448337,0.316880141672518,1.02401271345824,-5.44145982253705,0.785529791311604,"LOC101927610","uncharacterized LOC101927610",TRUE
+"215060_at",0.961395512423249,0.824732058521081,0.224101301858675,-5.9152520522298,0.15589576766633,"LOC101927610","uncharacterized LOC101927610",TRUE
+"1563135_at",0.612420348961838,0.0839364316051508,1.80965686805545,-4.45928546058385,1.48319031533447,"LOC101927616","uncharacterized LOC101927616",TRUE
+"233444_at",0.853004496782456,0.459322071044566,0.753092561155711,-5.66715852918165,0.443575659686355,"LOC101927620","uncharacterized LOC101927620",TRUE
+"1562487_at",0.969882914559333,0.85725566178634,-0.181976654014262,-5.92356699984207,-0.102160661086997,"LOC101927623","uncharacterized LOC101927623",TRUE
+"1561731_at",0.688234475234403,0.157666520665115,1.46242096812669,-4.94846606035833,0.929707851987343,"LOC101927636","uncharacterized LOC101927636",TRUE
+"240917_at",0.737123149977386,0.222651704609665,1.25472882191756,-5.20065744756012,0.565275109312521,"LOC101927640","uncharacterized LOC101927640",TRUE
+"1562523_at",0.920714895152417,0.66267896760929,0.442132400493925,-5.84491777446408,0.341447652324683,"LOC101927641","uncharacterized LOC101927641",TRUE
+"1561966_at",0.851319596585235,0.454993197586681,0.760465805579523,-5.66186923560959,0.743712797589064,"LOC101927647","uncharacterized LOC101927647",TRUE
+"1562925_at",0.863408882018863,0.48794055807995,-0.705352823322964,-5.70022109837401,-0.302148440395592,"LOC101927648","uncharacterized LOC101927648",TRUE
+"1563121_at",0.973736211250369,0.873457696220672,0.16112164224609,-5.92704713686425,0.113567210717322,"LOC101927650","uncharacterized LOC101927650",TRUE
+"244564_at",0.552420073963858,0.0495577727298528,2.07740484120696,-4.03142035674989,0.986396518888385,"LOC101927651","uncharacterized LOC101927651",TRUE
+"239584_at",0.976335130930535,0.885644951961624,-0.145482974986458,-5.9293799003269,-0.102525139241838,"LOC101927653","uncharacterized LOC101927653",TRUE
+"1562893_at",0.955645941042265,0.796863516442593,0.260526672010355,-5.90667845148645,0.204135409510529,"LOC101927657","uncharacterized LOC101927657",TRUE
+"1562543_at",0.710842845257879,0.184309651679989,-1.37032897353976,-5.06425668048394,-0.980298095545593,"LOC101927660","uncharacterized LOC101927660",TRUE
+"237192_at",0.843753336849204,0.43922625594257,0.787685916880543,-5.64192124881754,0.68895112759742,"LOC101927668","uncharacterized LOC101927668",TRUE
+"237193_s_at",0.971057280716553,0.861297171071774,-0.176767116542049,-5.92447585696833,-0.136253135251098,"LOC101927668","uncharacterized LOC101927668",TRUE
+"1559361_at",0.358427723880268,0.010001468429667,2.81682672129672,-2.67395538040037,2.31957338027052,"LOC101927668///MACC1","uncharacterized LOC101927668///metastasis associated in colon cancer 1",TRUE
+"201245_s_at",0.734042693548791,0.218440917926489,-1.26663198392337,-5.18708415705789,-0.450639794074519,"LOC101927673///OTUB1","uncharacterized LOC101927673///OTU deubiquitinase, ubiquitin aldehyde binding 1",TRUE
+"38710_at",0.777826511138126,0.296917410457569,-1.06823060344767,-5.39866476422903,-0.336430512966954,"LOC101927673///OTUB1","uncharacterized LOC101927673///OTU deubiquitinase, ubiquitin aldehyde binding 1",TRUE
+"201246_s_at",0.913627134030439,0.637588627488356,-0.477634433344282,-5.82917423336454,-0.220675959482497,"LOC101927673///OTUB1","uncharacterized LOC101927673///OTU deubiquitinase, ubiquitin aldehyde binding 1",TRUE
+"1561353_at",0.803706747165017,0.342253557951433,0.970540594691054,-5.49102228523681,0.569783764111605,"LOC101927690","uncharacterized LOC101927690",TRUE
+"244307_s_at",0.689848451630875,0.158990451522904,1.45756023632105,-4.95473142270382,0.668236758627434,"LOC101927699","uncharacterized LOC101927699",TRUE
+"244308_at",0.958723944343516,0.812795980941003,0.23966140218633,-5.91174640698125,0.172785346576985,"LOC101927699","uncharacterized LOC101927699",TRUE
+"1569727_at",0.859276375962637,0.476207553224851,0.724720857595483,-5.68705553702306,0.587558414070696,"LOC101927701","uncharacterized LOC101927701",TRUE
+"241144_at",0.62932992642067,0.100186101172838,-1.71561016650128,-4.59956018046701,-1.08866305296784,"LOC101927702","uncharacterized LOC101927702",TRUE
+"202733_at",0.768852835478002,0.272806624983936,1.12457133417231,-5.34179920418714,0.824357372208443,"LOC101927705///P4HA2","uncharacterized LOC101927705///prolyl 4-hydroxylase subunit alpha 2",TRUE
+"1555027_at",0.886148073306164,0.548931462912461,0.608672719824366,-5.7608284374625,0.550729388816064,"LOC101927705///P4HA2","uncharacterized LOC101927705///prolyl 4-hydroxylase subunit alpha 2",TRUE
+"234833_at",0.402463840838386,0.014728369638073,2.64529827297621,-3.0076679993357,1.89677806595766,"LOC101927709","uncharacterized LOC101927709",TRUE
+"1559629_at",0.757950630724418,0.254372465054142,1.17015306555604,-5.29390515507648,0.575361112016105,"LOC101927710","uncharacterized LOC101927710",TRUE
+"1570298_at",0.915235303483509,0.642363881057265,-0.470830844359999,-5.83228350865504,-0.259743549770425,"LOC101927719","uncharacterized LOC101927719",TRUE
+"1562902_at",0.728671251879936,0.210229563152751,1.29036095144374,-5.15969947015496,0.775868074231062,"LOC101927723","uncharacterized LOC101927723",TRUE
+"200944_s_at",0.925246803459608,0.676277255188115,0.423132659997445,-5.85285333744598,0.11957230686043,"LOC101927733///HMGN1","uncharacterized LOC101927733///high mobility group nucleosome binding domain 1",TRUE
+"1562049_at",0.875279162021058,0.522480379126802,0.649833936223157,-5.73607127661387,0.552393370349335,"LOC101927734","uncharacterized LOC101927734",TRUE
+"1560810_at",0.671498069723584,0.137636984780913,1.54034729939322,-4.84573619695551,1.21819218842347,"LOC101927735","uncharacterized LOC101927735",TRUE
+"1554887_at",0.792344934473527,0.323455486234257,1.00987861054383,-5.45479483036222,1.23762224141446,"LOC101927746","uncharacterized LOC101927746",TRUE
+"227092_at",0.724853010944214,0.202399350065032,-1.31366585114603,-5.13238420414409,-1.57300409783746,"LOC101927752","uncharacterized LOC101927752",TRUE
+"1569492_at",0.972819824894874,0.868464686468241,-0.167540335126739,-5.92602097434914,-0.0757009430333602,"LOC101927752","uncharacterized LOC101927752",TRUE
+"240745_at",0.893175412268596,0.567674402312196,-0.580139054277227,-5.777073104867,-0.449509225351175,"LOC101927760","uncharacterized LOC101927760",TRUE
+"240746_s_at",0.99783553534859,0.989849958203648,0.0128658612410438,-5.93960285732297,0.00866097315632874,"LOC101927760","uncharacterized LOC101927760",TRUE
+"1563484_at",0.704169628937146,0.176122902162148,1.39742600625911,-5.03083063592664,0.624078966671629,"LOC101927766","uncharacterized LOC101927766",TRUE
+"1559620_at",0.806466022727361,0.347440460271477,-0.959948345932017,-5.50055271867167,-0.513282632290207,"LOC101927768","uncharacterized LOC101927768",TRUE
+"233784_at",0.729605041831697,0.211882375019729,1.28552795319697,-5.16531216005077,0.417549000346862,"LOC101927769","uncharacterized LOC101927769",TRUE
+"215861_at",0.689913893405055,0.159143923614532,1.45699889292681,-4.95545388962218,0.786525795852863,"LOC101927770","uncharacterized LOC101927770",TRUE
+"1563341_at",0.765442453760984,0.265759379967897,1.14172078709236,-5.32397632854585,0.989236810746393,"LOC101927783","uncharacterized LOC101927783",TRUE
+"1557026_at",0.787859013911011,0.313745849289153,1.03082243480277,-5.43497534205847,0.640407967854313,"LOC101927787","uncharacterized LOC101927787",TRUE
+"1563154_at",0.627021415091472,0.0976303275399027,1.72949178969411,-4.5792032648507,0.96899000617687,"LOC101927790","uncharacterized LOC101927790",TRUE
+"217443_at",0.888979378354816,0.556508407552817,0.597077714536478,-5.76752054463962,0.50055321059149,"LOC101927792","uncharacterized LOC101927792",TRUE
+"1569841_x_at",0.7994347047598,0.334840993864535,0.9858702120175,-5.47706049991389,0.678205860380126,"LOC101927798","uncharacterized LOC101927798",TRUE
+"1569840_at",0.885029460971826,0.545290586551388,0.614274324760915,-5.75755095815554,0.32828350482149,"LOC101927798","uncharacterized LOC101927798",TRUE
+"1568633_a_at",0.528176582660474,0.0407586995862282,2.1728454057949,-3.86955089769067,0.94097607657143,"LOC101927809","uncharacterized LOC101927809",TRUE
+"230446_at",0.4584918480392,0.0228596027024209,2.44562853943035,-3.38318374227686,2.3155558058793,"LOC101927811","uncharacterized LOC101927811",TRUE
+"1568755_a_at",0.790657561917617,0.320369961165485,-1.01648588403324,-5.44858197688303,-0.670746181223901,"LOC101927814","uncharacterized LOC101927814",TRUE
+"1568754_at",0.819780516863333,0.37766130148612,0.900263441472801,-5.55245787624517,0.679293774726591,"LOC101927814","uncharacterized LOC101927814",TRUE
+"1562073_at",0.786019460727422,0.311460660569906,1.03581755768343,-5.43019414866655,0.746109316788062,"LOC101927815","uncharacterized LOC101927815",TRUE
+"1568848_at",0.515810181619652,0.0361050319956266,2.23114871062544,-3.76844933916825,1.65155543561512,"LOC101927820","uncharacterized LOC101927820",TRUE
+"230675_at",0.721484767988802,0.197702328701695,1.32798415819024,-5.11539713753351,0.79247556462829,"LOC101927824","translation initiation factor IF-2-like",TRUE
+"236405_at",0.314126572995991,0.00668920871558929,2.99167374942839,-2.32477463061045,0.912939984244187,"LOC101927826///FBXO41","uncharacterized LOC101927826///F-box protein 41",TRUE
+"221945_at",0.940044918888428,0.731362853076981,-0.347678471963435,-5.88097802617175,-0.136150195560221,"LOC101927826///FBXO41","uncharacterized LOC101927826///F-box protein 41",TRUE
+"44040_at",0.973654179023432,0.87317349891594,-0.161486799529455,-5.92698983132498,-0.0754486610249518,"LOC101927826///FBXO41","uncharacterized LOC101927826///F-box protein 41",TRUE
+"1560833_at",0.663983725174416,0.131995228329597,1.56397322700467,-4.81375354371389,1.04401401229747,"LOC101927827///LINC01189","uncharacterized LOC101927827///long intergenic non-protein coding RNA 1189",TRUE
+"1561704_at",0.88082806716658,0.536529228382581,-0.627836039230471,-5.74949623613155,-0.204021385338158,"LOC101927829","uncharacterized LOC101927829",TRUE
+"1560797_s_at",0.625576683341349,0.0967645047611651,-1.7342648521237,-4.57217552513506,-1.10503815411277,"LOC101927830///TMLHE-AS1","uncharacterized LOC101927830///TMLHE antisense RNA 1",TRUE
+"231459_at",0.938687463999329,0.726725224757706,-0.353946170430781,-5.87884876700813,-0.169005923837217,"LOC101927839","uncharacterized LOC101927839",TRUE
+"239823_at",0.13804695369145,0.000908705868486542,3.82745362390449,-0.572148998060158,4.07932276434188,"LOC101927841","uncharacterized LOC101927841",TRUE
+"1563107_at",0.740610299769501,0.230139278002182,1.23398114234336,-5.22405298968765,1.05269373475815,"LOC101927843","uncharacterized LOC101927843",TRUE
+"1561305_at",0.83633038614858,0.417829169586809,0.825605500926421,-5.61303316277149,0.456562348303144,"LOC101927849","uncharacterized LOC101927849",TRUE
+"1570285_at",0.737123149977386,0.222917783546376,-1.25398247328977,-5.20150485633754,-0.652190099068076,"LOC101927851","uncharacterized LOC101927851",TRUE
+"236399_at",0.809707978333974,0.353098886198282,-0.948515091113366,-5.51073245834148,-0.666336381643526,"LOC101927851","uncharacterized LOC101927851",TRUE
+"236398_s_at",0.979794616772313,0.903700807926405,-0.122380646637501,-5.93239135697598,-0.0931982696394007,"LOC101927851","uncharacterized LOC101927851",TRUE
+"1563044_at",0.85334340854827,0.461058291131342,-0.750147012414582,-5.66925792137506,-0.500561478494691,"LOC101927865","uncharacterized LOC101927865",TRUE
+"1562634_at",0.83171794972459,0.406424674679001,0.846315713249097,-5.59671888871427,0.347522390562419,"LOC101927869","uncharacterized LOC101927869",TRUE
+"1557599_a_at",0.73826901296725,0.22512572539124,-1.24781534414035,-5.20849048691255,-1.15966097966648,"LOC101927870","uncharacterized LOC101927870",TRUE
+"1557598_at",0.933548873991014,0.705857535027738,0.382332515074936,-5.86873520829969,0.36851260556384,"LOC101927870","uncharacterized LOC101927870",TRUE
+"1561311_at",0.962555471240652,0.829561191463406,-0.217822211955835,-5.91660041857289,-0.121354862962749,"LOC101927876","uncharacterized LOC101927876",TRUE
+"1561436_at",0.896139457361073,0.578675805790399,-0.563616040796831,-5.78613475635694,-0.163043993645665,"LOC101927877","uncharacterized LOC101927877",TRUE
+"1570230_at",0.700061364939874,0.17178134822398,1.4122050597491,-5.01237180023499,0.586202157685697,"LOC101927884","uncharacterized LOC101927884",TRUE
+"1561253_at",0.975550833930114,0.883442079037351,-0.14830683278179,-5.92897624258882,-0.0893258074290739,"LOC101927901","uncharacterized LOC101927901",TRUE
+"1570273_at",0.819018525257656,0.375141768123975,0.905115065945098,-5.54835326786851,0.72745729558747,"LOC101927907","uncharacterized LOC101927907",TRUE
+"1562272_at",0.689023691674439,0.158031222562368,-1.46107870128887,-4.95019790041947,-1.01434866149523,"LOC101927914","uncharacterized LOC101927914",TRUE
+"1568853_at",0.969183235742461,0.854005631055373,-0.186169704369817,-5.92281636796751,-0.136062067109,"LOC101927929","uncharacterized LOC101927929",TRUE
+"1562712_at",0.402463840838386,0.0148333679573391,-2.64211553947142,-3.0137682565391,-1.33730263710112,"LOC101927933///LRRC8C","uncharacterized LOC101927933///leucine rich repeat containing 8 family member C",TRUE
+"1558517_s_at",0.64513208805899,0.115958622926945,1.63604027725606,-4.71385220051849,1.3081060574364,"LOC101927933///LRRC8C","uncharacterized LOC101927933///leucine rich repeat containing 8 family member C",TRUE
+"1570007_at",0.710883166549249,0.18464109461666,1.36925220543858,-5.06557371422813,0.349941210409932,"LOC101927933///LRRC8C","uncharacterized LOC101927933///leucine rich repeat containing 8 family member C",TRUE
+"228314_at",0.71384876672751,0.188988768145966,1.35526726995114,-5.08260075927831,0.95493330138216,"LOC101927933///LRRC8C","uncharacterized LOC101927933///leucine rich repeat containing 8 family member C",TRUE
+"223533_at",0.998870448604467,0.99547477632655,0.00573589311416752,-5.93966745615598,0.00523358543701402,"LOC101927933///LRRC8C","uncharacterized LOC101927933///leucine rich repeat containing 8 family member C",TRUE
+"1568643_a_at",0.8920930097751,0.563213144435474,0.586885908837035,-5.773300075062,0.659656933155036,"LOC101927934","uncharacterized LOC101927934",TRUE
+"1569785_at",0.96287357728432,0.83137388350048,-0.215467579296506,-5.91709621723683,-0.157546885783926,"LOC101927943","uncharacterized LOC101927943",TRUE
+"1561559_at",0.872010957446544,0.51476520033232,0.66205240533456,-5.72842284771982,0.330217874102074,"LOC101927948","uncharacterized LOC101927948",TRUE
+"234177_at",0.971242929121865,0.863381424796932,0.174082461817127,-5.92493394701865,0.102525711688491,"LOC101927950","uncharacterized LOC101927950",TRUE
+"1561499_at",0.519324000973296,0.0373761306598979,2.21457541707457,-3.79735455871376,1.15002232549962,"LOC101927958","uncharacterized LOC101927958",TRUE
+"1557778_at",0.879389294797525,0.533472046270586,0.632596171858732,-5.74662889671015,0.407886777638042,"LOC101927967","uncharacterized LOC101927967",TRUE
+"240361_at",0.914588178928864,0.640355562602901,-0.473689449811798,-5.83098242839369,-0.436009279071196,"LOC101927972","uncharacterized LOC101927972",TRUE
+"228753_at",0.853460708803218,0.461830280173523,0.748839439176156,-5.67018737599847,0.401314943434961,"LOC101927974","uncharacterized LOC101927974",TRUE
+"236075_s_at",0.845247281818468,0.44224945571067,0.782421073297529,-5.64583113947574,0.537360081266097,"LOC101928000","uncharacterized LOC101928000",TRUE
+"236611_at",0.963379172403332,0.832891194784777,0.213497595428399,-5.91750690136761,0.172957616182089,"LOC101928000","uncharacterized LOC101928000",TRUE
+"1557606_at",0.740831878055147,0.231090766899507,-1.23138158452304,-5.22696062482811,-0.485562447704379,"LOC101928002","uncharacterized LOC101928002",TRUE
+"1561345_at",0.550991393497823,0.0492591848453106,2.08038376647146,-4.02643837836095,1.22167318750554,"LOC101928009","uncharacterized LOC101928009",TRUE
+"1561550_at",0.991249206045988,0.959005784219294,-0.0519858910002562,-5.93836726235599,-0.0421161406106574,"LOC101928012","uncharacterized LOC101928012",TRUE
+"240012_at",0.837368340567858,0.42106531773393,0.819793927298891,-5.6175432171991,0.374593047766709,"LOC101928014","uncharacterized LOC101928014",TRUE
+"1558595_at",0.940044918888428,0.731502328450436,-0.347490193684982,-5.88104140630587,-0.319776555048744,"LOC101928020","uncharacterized LOC101928020",TRUE
+"1563427_at",0.716245563733659,0.192020621366401,-1.34566421958721,-5.0942081210871,-1.01036947378198,"LOC101928031","uncharacterized LOC101928031",TRUE
+"237381_at",0.745508528302503,0.237053094165691,-1.21527410347731,-5.24485889194803,-0.976383930564914,"LOC101928035","uncharacterized LOC101928035",TRUE
+"243336_at",0.755639383619058,0.249777115988475,1.1818951531761,-5.28129727721332,0.412652088893086,"LOC101928042///LOC101927579","uncharacterized LOC101928042///dynamin-1-like",TRUE
+"1559372_at",0.98539961718117,0.92851116198549,0.0907442796388935,-5.93567354329667,0.0632425809939114,"LOC101928043","uncharacterized LOC101928043",TRUE
+"231095_at",0.909052380289506,0.622657856641279,0.499057454520109,-5.81909901991291,0.194288058239364,"LOC101928045","uncharacterized LOC101928045",TRUE
+"1559131_a_at",0.689168483917391,0.158266942521416,1.46021247927153,-4.95131484571979,0.763190813655319,"LOC101928047","uncharacterized LOC101928047",TRUE
+"1569712_at",0.885642044221123,0.547291956983979,-0.611192712227194,-5.759357582354,-0.435771889895721,"LOC101928052","uncharacterized LOC101928052",TRUE
+"1560156_at",0.980439435497171,0.90866320071088,0.116043778953307,-5.93312673904266,0.0647493648612167,"LOC101928054","uncharacterized LOC101928054",TRUE
+"235883_at",0.62524538993269,0.0965856826794225,1.73525519694398,-4.57071556333682,0.927272736555719,"LOC101928068","uncharacterized LOC101928068",TRUE
+"1557674_s_at",0.777547149102231,0.296520712889213,1.06913041385027,-5.39777706065023,0.960890201884919,"LOC101928068","uncharacterized LOC101928068",TRUE
+"236997_at",0.773234064853267,0.284374004370844,1.09711042642498,-5.36984068530702,0.423782105989321,"LOC101928069","uncharacterized LOC101928069",TRUE
+"244214_at",0.835222806930914,0.414197186778689,0.832161786134544,-5.60790938517679,0.266632732703057,"LOC101928069","uncharacterized LOC101928069",TRUE
+"240382_at",0.877488742289724,0.527543750525524,-0.641868964746689,-5.74098348363727,-0.53228067472398,"LOC101928076","uncharacterized LOC101928076",TRUE
+"241767_at",0.910888708415045,0.628469267886373,-0.490691493954085,-5.82308491446082,-0.182124571932527,"LOC101928087","uncharacterized LOC101928087",TRUE
+"1560533_at",0.922168942129244,0.667455699575614,-0.435439779003819,-5.84775210365653,-0.278697670087758,"LOC101928098","uncharacterized LOC101928098",TRUE
+"242873_at",0.497725944448536,0.0307586908379295,2.30726032111018,-3.63405989705755,1.33659689758124,"LOC101928100","uncharacterized LOC101928100",TRUE
+"1562747_at",0.900171779891306,0.59487820982346,0.539565509595351,-5.7988705481202,0.38704660355902,"LOC101928101","uncharacterized LOC101928101",TRUE
+"1569828_at",0.931560290412494,0.697482493776172,0.393814327165649,-5.86442601012721,0.144599628862931,"LOC101928107","uncharacterized LOC101928107",TRUE
+"237764_at",0.875112066318152,0.521962132504824,-0.650651549525787,-5.73556374100082,-0.46715694509242,"LOC101928111","uncharacterized LOC101928111",TRUE
+"1569338_at",0.489464245681026,0.0291306201270427,2.33285534321219,-3.58827633417708,1.77201001417821,"LOC101928123","uncharacterized LOC101928123",TRUE
+"1569339_s_at",0.88113080359582,0.537492609963962,0.626339049555723,-5.75039366207194,0.340503636992358,"LOC101928123","uncharacterized LOC101928123",TRUE
+"1560589_a_at",0.966925852992772,0.845715311454263,0.19688119400144,-5.92082145588039,0.11989226137886,"LOC101928132","uncharacterized LOC101928132",TRUE
+"231436_at",0.519956259865057,0.0374701601212348,2.21336986918353,-3.79945203405336,1.10510907288598,"LOC101928134","uncharacterized LOC101928134",TRUE
+"1563015_at",0.987977863996795,0.942658275832113,0.0727494062784221,-5.93710603949714,0.0488062918528165,"LOC101928135","uncharacterized LOC101928135",TRUE
+"1570106_at",0.78306465288477,0.305592144464606,1.04876494072562,-5.41770442187923,0.725629344842107,"LOC101928139","uncharacterized LOC101928139",TRUE
+"1568898_at",0.91728817904017,0.650093218303773,-0.45986583063246,-5.83720265504745,-0.372562345687177,"LOC101928140","uncharacterized LOC101928140",TRUE
+"1562557_at",0.99176128617116,0.962008219917723,0.0481752181469748,-5.9385531427026,0.0207060932538505,"LOC101928144","uncharacterized LOC101928144",TRUE
+"236595_at",0.867580082241907,0.500322533738378,0.685202533759221,-5.71355742153837,0.620087478698639,"LOC101928152","uncharacterized LOC101928152",TRUE
+"232076_at",0.80861715520522,0.351807087977187,0.951114264414736,-5.50842806195725,0.287117994735234,"LOC101928160///ZNF707","uncharacterized LOC101928160///zinc finger protein 707",TRUE
+"1562944_at",0.935656469484638,0.713580310280209,-0.37179114625098,-5.87258074619405,-0.202349436908974,"LOC101928160///ZNF707","uncharacterized LOC101928160///zinc finger protein 707",TRUE
+"1560506_at",0.877944644261883,0.529496564143312,0.63880823490962,-5.74285563351359,0.360422459801994,"LOC101928161","uncharacterized LOC101928161",TRUE
+"231446_at",0.86921531641038,0.506267247390737,0.675628904749,-5.71976423350368,0.371231178717915,"LOC101928162","uncharacterized LOC101928162",TRUE
+"1560954_at",0.922168942129244,0.667856531262629,-0.434879100867705,-5.84798762444457,-0.271294756131767,"LOC101928167","uncharacterized LOC101928167",TRUE
+"236787_at",0.928044491058679,0.683960727338079,-0.412467244545428,-5.85715781422037,-0.286001109596944,"LOC101928173","uncharacterized LOC101928173",TRUE
+"1561460_at",0.54295328972902,0.0460362156183019,2.11361340058113,-3.97055377419687,1.16508830238084,"LOC101928185","uncharacterized LOC101928185",TRUE
+"1560070_at",0.871206814961775,0.511893027457979,0.666626945962037,-5.72552417153326,0.241194047722774,"LOC101928191","uncharacterized LOC101928191",TRUE
+"225520_at",0.676294804179428,0.143002659154834,1.51860663330238,-4.87482562152659,1.17888074993812,"LOC101928195///LOC100996643///MTHFD1L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene///monofunctional C1-tetrahydrofolate synthase, mitochondrial-like///methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like",TRUE
+"231094_s_at",0.679041081350052,0.146587255074988,1.50445262501203,-4.8935866847889,1.48714737639462,"LOC101928195///LOC100996643///MTHFD1L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene///monofunctional C1-tetrahydrofolate synthase, mitochondrial-like///methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like",TRUE
+"1561719_at",0.865854896594418,0.496092225290213,0.692054514890372,-5.70906388505554,0.383045159612752,"LOC101928196","uncharacterized LOC101928196",TRUE
+"1562973_at",0.83646069438128,0.418146203910912,0.825034913184563,-5.61347728642137,0.695986376937762,"LOC101928201","uncharacterized LOC101928201",TRUE
+"1561389_at",0.579111490485788,0.0621849759605315,1.96410510871772,-4.21739231171958,0.495613620007236,"LOC101928205","uncharacterized LOC101928205",TRUE
+"1570372_at",0.695812999227098,0.1659270481966,1.43261432973497,-4.98661869899598,1.02458786021396,"LOC101928207","uncharacterized LOC101928207",TRUE
+"1559930_at",0.950867616491248,0.775407106518131,-0.288815971844749,-5.89913674044672,-0.279246662884733,"LOC101928211","uncharacterized LOC101928211",TRUE
+"230390_at",0.936992192746977,0.718004435797683,0.365771693419644,-5.87472908348698,0.218367439174171,"LOC101928222","uncharacterized LOC101928222",TRUE
+"1564819_at",0.925511384407886,0.67800286307498,0.420733041748363,-5.85383122326676,0.366565122482699,"LOC101928225","uncharacterized LOC101928225",TRUE
+"230386_at",0.833150500087421,0.410457098680471,-0.838951322466329,-5.60256338518881,-0.524799103906761,"LOC101928230","uncharacterized LOC101928230",TRUE
+"1557287_at",0.726696341943087,0.206582254877519,1.30113102144658,-5.14712756362098,0.610269456866058,"LOC101928231","uncharacterized LOC101928231",TRUE
+"1556776_a_at",0.90344422113846,0.604056308100515,0.526084103127914,-5.80577336993604,0.332303034045602,"LOC101928238","uncharacterized LOC101928238",TRUE
+"1556777_a_at",0.915438698231633,0.643632236709001,0.469027539561526,-5.8331003086071,0.253951583486044,"LOC101928238","uncharacterized LOC101928238",TRUE
+"1561595_x_at",0.975913043793143,0.884810468942022,0.146552553089856,-5.92922792001327,0.0739489489913714,"LOC101928238","uncharacterized LOC101928238",TRUE
+"1561418_at",0.740681080735184,0.230958546468685,1.23174233632493,-5.2265574358416,0.403316789448597,"LOC101928245","uncharacterized LOC101928245",TRUE
+"1560410_at",0.740610299769501,0.230630711754388,1.23263748150886,-5.22555654992663,0.742999229219815,"LOC101928251","uncharacterized LOC101928251",TRUE
+"1569912_at",0.85334340854827,0.460295027784034,0.751441092753892,-5.66833654596125,0.439919158483622,"LOC101928255","uncharacterized LOC101928255",TRUE
+"237219_at",0.909441642299191,0.623900219114979,-0.497265964861037,-5.81995809733251,-0.277482638903825,"LOC101928259","uncharacterized LOC101928259",TRUE
+"1570350_at",0.968035667633768,0.849252051982037,-0.192308747564392,-5.9216866296779,-0.176356838020749,"LOC101928269","uncharacterized LOC101928269",TRUE
+"211182_x_at",0.559388432054223,0.0538772653534072,2.03601582360311,-4.10015728049634,1.51767366808734,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"211620_x_at",0.567915942389722,0.0578562743321582,2.00043018640177,-4.15852496208258,1.08400081718833,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"211179_at",0.615821255316333,0.0867749186572725,1.79216015581735,-4.48579710513833,1.55014842491994,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"211181_x_at",0.657015752622694,0.126017685137671,1.58993589651017,-4.7781670536575,0.933316890706878,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"210805_x_at",0.697172073261335,0.167217949093861,1.42806491826479,-4.99238553209704,0.982050666606828,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"217263_x_at",0.712948021516228,0.187061354763906,1.3614354043689,-5.07510885943532,0.908085312844606,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"1563591_at",0.743323328391634,0.233509989721798,-1.22480843186234,-5.23428915948948,-0.921131671510298,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"237697_at",0.831875452294783,0.406840486706854,-0.845554172415696,-5.59732546956383,-0.347027132554795,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"210365_at",0.858826390511142,0.47503076251125,0.726678706837211,-5.68570580096842,0.370080706829372,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"211180_x_at",0.87579870142401,0.523745868461152,0.64783930239859,-5.73730688014023,0.394447038675986,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"209359_x_at",0.925511384407886,0.678196516137476,0.420463906113889,-5.85394055970848,0.169577547362795,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"209360_s_at",0.947778780715578,0.761761103727601,0.306932131826286,-5.89390244141722,0.148399123149494,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"208129_x_at",0.99187501204911,0.962644607845337,0.047367614358084,-5.93859072072703,0.0189757125794241,"LOC101928269///LOC100506403///RUNX1","uncharacterized LOC101928269///uncharacterized LOC100506403///runt related transcription factor 1",TRUE
+"1562860_at",0.949820165200312,0.772698417981279,-0.292403935525714,-5.89812513997455,-0.238289148286036,"LOC101928271","uncharacterized LOC101928271",TRUE
+"1561535_at",0.796378050779806,0.328959961545557,0.998199575325359,-5.46568685307546,0.854582079560756,"LOC101928273","uncharacterized LOC101928273",TRUE
+"1553991_s_at",0.774230543658252,0.28978716457024,1.08453706801648,-5.38247408806694,0.630491578744026,"LOC101928274///VSIG10","uncharacterized LOC101928274///V-set and immunoglobulin domain containing 10",TRUE
+"220137_at",0.775128125264818,0.29157860360899,1.08041330409668,-5.38658926563601,0.579532964265626,"LOC101928274///VSIG10","uncharacterized LOC101928274///V-set and immunoglobulin domain containing 10",TRUE
+"226485_at",0.780614263830306,0.302180171814695,1.0563737283638,-5.41029954493107,0.61384503342266,"LOC101928274///VSIG10","uncharacterized LOC101928274///V-set and immunoglobulin domain containing 10",TRUE
+"1562771_at",0.999503346640971,0.998816159795883,0.00150055447279884,-5.93968238404678,0.000643079585326056,"LOC101928277","uncharacterized LOC101928277",TRUE
+"217439_at",0.957571530817866,0.80904549903194,-0.244562932928365,-5.91059364946403,-0.205360947437618,"LOC101928278","uncharacterized LOC101928278",TRUE
+"1561612_at",0.831875452294783,0.407103730896451,0.845072309198622,-5.59770901899846,0.440576477015335,"LOC101928280","uncharacterized LOC101928280",TRUE
+"1562850_at",0.869082033398093,0.505922847764275,0.676181805759422,-5.719408047386,0.320179898118291,"LOC101928283","uncharacterized LOC101928283",TRUE
+"1569802_at",0.773754791548713,0.285246665924404,1.09507184777796,-5.37189780613244,0.543741994752315,"LOC101928284","uncharacterized LOC101928284",TRUE
+"234773_x_at",0.885029460971826,0.54597480126255,-0.613220131287179,-5.75816997496892,-0.411027753605708,"LOC101928288","uncharacterized LOC101928288",TRUE
+"232758_s_at",0.771158062322823,0.28019800761052,-1.10692894273238,-5.35988523432222,-0.49091624705,"LOC101928291","uncharacterized LOC101928291",TRUE
+"1562152_at",0.968980656821882,0.853366900137755,-0.186994166952439,-5.92266676934064,-0.105782135348421,"LOC101928298","uncharacterized LOC101928298",TRUE
+"1557776_at",0.917166618334994,0.649899541395246,0.460139881525854,-5.83708109317636,0.242874331184775,"LOC101928303","uncharacterized LOC101928303",TRUE
+"239882_at",0.800722093591725,0.336632794573377,0.98214347582648,-5.48047304541028,0.663354693054377,"LOC101928304","uncharacterized LOC101928304",TRUE
+"1569855_at",0.804537788156734,0.343431630324132,0.968125276214354,-5.49320388854736,0.579222653827158,"LOC101928306","uncharacterized LOC101928306",TRUE
+"1558795_at",0.648301983183996,0.119425158168162,1.61978678777864,-4.73668777012169,1.48009915524719,"LOC101928307","uncharacterized LOC101928307",TRUE
+"1561565_at",0.421158920993522,0.0175011077914455,2.56762866359591,-3.15551037102087,1.49174421606369,"LOC101928309","uncharacterized LOC101928309",TRUE
+"1562595_at",0.724630099893865,0.202061463246125,1.31468715829494,-5.13117768547178,1.12152575558903,"LOC101928314","uncharacterized LOC101928314",TRUE
+"1561622_at",0.841967750949524,0.434886688994678,0.795282236465042,-5.63623640704948,0.526716118915981,"LOC101928314","uncharacterized LOC101928314",TRUE
+"222639_s_at",0.995628848184154,0.979258105897596,0.026294155242824,-5.93934673938631,0.0192631305025301,"LOC101928317///PLBD1-AS1","uncharacterized LOC101928317///PLBD1 antisense RNA 1",TRUE
+"241743_at",0.955730092376044,0.797532839774593,0.259647805202557,-5.90690039547607,0.144117143339671,"LOC101928323","uncharacterized LOC101928323",TRUE
+"242510_at",0.69254384039609,0.162055891980386,1.44642999339428,-4.96901415062213,0.590221595678821,"LOC101928324","uncharacterized LOC101928324",TRUE
+"1561605_at",0.844788904109563,0.441762063035144,-0.783268364561093,-5.64520357402412,-0.298931271424996,"LOC101928326","uncharacterized LOC101928326",TRUE
+"1560656_at",0.755049574909504,0.24864171960782,1.18482112664634,-5.27813845229269,0.748457321082938,"LOC101928327","uncharacterized LOC101928327",TRUE
+"237982_at",0.947326616179611,0.760473609372852,-0.308646712009359,-5.89339070341965,-0.117773231831277,"LOC101928327","uncharacterized LOC101928327",TRUE
+"1561427_at",0.79574560841667,0.327962168085253,-1.00030650596702,-5.46373039832616,-0.535171495652416,"LOC101928333","uncharacterized LOC101928333",TRUE
+"1556903_at",0.857999051529531,0.473684524378946,0.728921962045305,-5.68415505368828,0.368142941004893,"LOC101928335","uncharacterized LOC101928335",TRUE
+"1556747_a_at",0.820536502908875,0.379835458206738,0.896093984393056,-5.55596905514383,0.462475403995675,"LOC101928343","uncharacterized LOC101928343",TRUE
+"1556748_x_at",0.822173415758858,0.386537488647687,0.883338959249605,-5.56661659487966,0.46041090787735,"LOC101928343","uncharacterized LOC101928343",TRUE
+"218870_at",0.696769924950722,0.166549358009712,-1.43041764021747,-4.98940509655358,-1.59980989609552,"LOC101928361///ARHGAP15","uncharacterized LOC101928361///Rho GTPase activating protein 15",TRUE
+"1561489_at",0.913160385122315,0.635650382142711,0.480402488171709,-5.8278967295159,0.433606182729026,"LOC101928361///ARHGAP15","uncharacterized LOC101928361///Rho GTPase activating protein 15",TRUE
+"244422_at",0.689243424115541,0.158356762657069,1.45988268356524,-4.95173995773902,1.23213124366147,"LOC101928370","uncharacterized LOC101928370",TRUE
+"1568804_at",0.482805047227557,0.0275458741802789,2.35906485328653,-3.5410945214137,1.3433396374512,"LOC101928371","uncharacterized LOC101928371",TRUE
+"1560538_at",0.640067422642767,0.110789847843829,-1.66105015669082,-4.67837300256882,-1.30538162841248,"LOC101928386","uncharacterized LOC101928386",TRUE
+"1562822_at",0.62110896023334,0.0915560676968495,1.76377416982067,-4.52840879289197,1.43470418649707,"LOC101928389","uncharacterized LOC101928389",TRUE
+"1569486_at",0.695812999227098,0.165902351242532,1.43270164394891,-4.98650787273379,1.29753387822499,"LOC101928401","uncharacterized LOC101928401",TRUE
+"236990_at",0.94118897722809,0.736867668605087,-0.340257141012457,-5.88345057081963,-0.14020490098748,"LOC101928403","uncharacterized LOC101928403",TRUE
+"1564323_at",0.964693183005833,0.836826123156848,0.208392729162122,-5.91855364053943,0.0809431815580393,"LOC101928405","uncharacterized LOC101928405",TRUE
+"242934_at",0.895213601869362,0.573288813695746,-0.571686679133043,-5.78174030044478,-0.367910646004641,"LOC101928409","uncharacterized LOC101928409",TRUE
+"1562857_at",0.903383391791809,0.603478238749351,-0.526930278329507,-5.80534510650942,-0.437540570348474,"LOC101928417","uncharacterized LOC101928417",TRUE
+"1561554_at",0.951518251175176,0.7778520302611,-0.285580716578129,-5.90003827445643,-0.160666054855863,"LOC101928418","uncharacterized LOC101928418",TRUE
+"240456_at",0.807167370609991,0.348495527217548,0.957806977448388,-5.5024678080139,0.363242413508448,"LOC101928419","uncharacterized LOC101928419",TRUE
+"239315_at",0.952697366942815,0.783385503575609,-0.278269945191482,-5.90203837262805,-0.220973204951898,"LOC101928422///TCAF2","TRPM8 channel-associated factor 2-like///TRPM8 channel associated factor 2",TRUE
+"1564027_a_at",0.831392326632573,0.405698166887189,-0.847647473225273,-5.59565689373531,-0.649719644347241,"LOC101928422///TCAF2P1///TCAF2","TRPM8 channel-associated factor 2-like///TRPM8 channel associated factor 2 pseudogene 1///TRPM8 channel associated factor 2",TRUE
+"1564028_s_at",0.921979068831802,0.667045477003262,-0.436013739899926,-5.84751069463643,-0.180006259902639,"LOC101928422///TCAF2P1///TCAF2","TRPM8 channel-associated factor 2-like///TRPM8 channel associated factor 2 pseudogene 1///TRPM8 channel associated factor 2",TRUE
+"239241_at",0.979388236370534,0.90074402290193,0.126158821468356,-5.93193433251974,0.099588632985272,"LOC101928424","uncharacterized LOC101928424",TRUE
+"242714_at",0.74057407812241,0.229845478402545,1.23478548055119,-5.22315225728149,0.622293304158879,"LOC101928429","uncharacterized LOC101928429",TRUE
+"243179_at",0.807528762746328,0.34873562993821,0.957320279296825,-5.50290253092693,0.419874812185549,"LOC101928433","uncharacterized LOC101928433",TRUE
+"244570_at",0.823105027705579,0.389926718291764,0.876943659216883,-5.57190194279901,0.588056831526286,"LOC101928433","uncharacterized LOC101928433",TRUE
+"1561481_at",0.764077045023402,0.26410734853216,1.1457892481375,-5.31971321678083,0.730335845577097,"LOC101928435","uncharacterized LOC101928435",TRUE
+"1562058_at",0.720952283360079,0.197092565593211,1.32986237478838,-5.11315733490414,0.831129324413222,"LOC101928441","uncharacterized LOC101928441",TRUE
+"1561446_at",0.980009054680439,0.90521862791777,0.120441890865182,-5.93262049062342,0.08033386627692,"LOC101928443","uncharacterized LOC101928443",TRUE
+"1562274_at",0.987223586799491,0.940403819802306,-0.0756152280391699,-5.93689900171803,-0.0392517653724429,"LOC101928446","uncharacterized LOC101928446",TRUE
+"1562923_at",0.75536453281804,0.249370513457463,-1.18294184417359,-5.28016807261149,-0.919581452921463,"LOC101928449","uncharacterized LOC101928449",TRUE
+"217034_at",0.707593266152278,0.179003314381115,-1.38778029566835,-5.04279145837978,-1.02048261064214,"LOC101928457","uncharacterized LOC101928457",TRUE
+"217151_at",0.767945391174396,0.270534084434545,1.13006570192672,-5.33611501147325,0.893849986806084,"LOC101928457","uncharacterized LOC101928457",TRUE
+"1562589_at",0.46481156911694,0.0239568175907002,2.42397989829576,-3.4229684751523,1.46917472183747,"LOC101928460","uncharacterized LOC101928460",TRUE
+"236785_at",0.90344422113846,0.604060579412641,0.526077852248929,-5.80577653111704,0.166228988212239,"LOC101928461","uncharacterized LOC101928461",TRUE
+"236485_at",0.943824539742785,0.748412947806022,-0.324754849270163,-5.88844516828705,-0.154825834034885,"LOC101928464","uncharacterized LOC101928464",TRUE
+"1561577_at",0.864894115958506,0.493427871633746,0.696387166191904,-5.7062004985835,0.514773544186557,"LOC101928475","uncharacterized LOC101928475",TRUE
+"1562719_at",0.819018525257656,0.373179506065755,0.908908531001257,-5.54512969798549,0.335223901802292,"LOC101928476","uncharacterized LOC101928476",TRUE
+"231312_at",0.804988948559952,0.344144858746655,-0.966665742658783,-5.49451978623607,-0.359742938774013,"LOC101928487","uncharacterized LOC101928487",TRUE
+"1561567_at",0.780095745457321,0.301480075016245,1.05794250186314,-5.40876683987815,0.827548697484913,"LOC101928491","uncharacterized LOC101928491",TRUE
+"1564909_at",0.860085676417428,0.479260168390294,0.719655326526229,-5.69053163433802,0.68632671050262,"LOC101928495","uncharacterized LOC101928495",TRUE
+"1559009_at",0.947001578829888,0.759397006639552,-0.310081168947524,-5.89296040165444,-0.167798082356748,"LOC101928504","uncharacterized LOC101928504",TRUE
+"1559336_at",0.358427723880268,0.0101093613935442,2.81211805073974,-2.68323959929478,1.82725856276046,"LOC101928505","uncharacterized LOC101928505",TRUE
+"1569988_at",0.716472449896956,0.19250055318501,1.34415504048037,-5.09602600503929,1.38557600482361,"LOC101928510","uncharacterized LOC101928510",TRUE
+"1560958_s_at",0.963379172403332,0.83296301569396,-0.213404369046422,-5.91752624328138,-0.122682742104002,"LOC101928516","uncharacterized LOC101928516",TRUE
+"1564169_at",0.556381379241158,0.0519065148316946,2.05451687998408,-4.06954342370879,1.59253650714663,"LOC101928519","uncharacterized LOC101928519",TRUE
+"238085_at",0.713633547141264,0.18876809695605,1.35597094390389,-5.08174750327878,1.2638111518692,"LOC101928521","uncharacterized LOC101928521",TRUE
+"232473_at",0.962741248200658,0.830525516714302,-0.216569426413073,-5.91686487671906,-0.203035681659987,"LOC101928524","uncharacterized LOC101928524",TRUE
+"223685_s_at",0.899998627338565,0.594148951471953,0.540641011487016,-5.79831254783147,0.320313866715796,"LOC101928524///PRPF18","uncharacterized LOC101928524///pre-mRNA processing factor 18",TRUE
+"1569963_at",0.943988850936011,0.74922831218577,-0.32366313580456,-5.88878821527071,-0.157156262585485,"LOC101928525","uncharacterized LOC101928525",TRUE
+"1569758_at",0.822173415758858,0.386665975689912,0.883095846103223,-5.56681816520106,0.559498628412955,"LOC101928526","uncharacterized LOC101928526",TRUE
+"1561443_at",0.714590421965913,0.189929360167068,-1.35227515925545,-5.08622477729037,-0.958776493244958,"LOC101928535","uncharacterized LOC101928535",TRUE
+"1557758_at",0.728385463227073,0.209300512193447,-1.29309050799899,-5.15652165238748,-0.848716543115337,"LOC101928535","uncharacterized LOC101928535",TRUE
+"1561210_at",0.822850703882235,0.388489546635007,0.879651090371805,-5.56966875554133,0.45699688045928,"LOC101928539","uncharacterized LOC101928539",TRUE
+"1564078_at",0.755820263931272,0.250156808342027,-1.18091888345086,-5.2823497225787,-0.826250080699987,"LOC101928551","uncharacterized LOC101928551",TRUE
+"1561451_a_at",0.833285547058304,0.410674026730755,-0.838556454886527,-5.60287541091914,-0.569529930214599,"LOC101928551","uncharacterized LOC101928551",TRUE
+"1561452_at",0.873503160020533,0.518813747023444,-0.655628238082181,-5.73246123973386,-0.563995076298558,"LOC101928551","uncharacterized LOC101928551",TRUE
+"221337_s_at",0.91728817904017,0.650096015539599,-0.459861872833643,-5.83720441010461,-0.227327877686267,"LOC101928551///ADAM29","uncharacterized LOC101928551///ADAM metallopeptidase domain 29",TRUE
+"1562710_at",0.984397001287044,0.924000100460857,-0.0964884387336949,-5.93514993096488,-0.0729267392684014,"LOC101928553","uncharacterized LOC101928553",TRUE
+"239887_at",0.51531387545335,0.0359942147298828,2.23261866643395,-3.76587932616251,1.67378137293839,"LOC101928554","uncharacterized LOC101928554",TRUE
+"243425_at",0.994304286761558,0.974068951648693,0.0328745892436424,-5.939157106524,0.0203086296747768,"LOC101928557","uncharacterized LOC101928557",TRUE
+"244618_at",0.972438691973544,0.867149453695732,0.169232302309866,-5.9257438205674,0.062757569617097,"LOC101928560","uncharacterized LOC101928560",TRUE
+"1561625_at",0.728385463227073,0.209045177211895,-1.29384232583908,-5.15564536529487,-0.861578409377842,"LOC101928565","uncharacterized LOC101928565",TRUE
+"233712_at",0.690330257199992,0.159904888172183,1.45422201694607,-4.95902449206661,0.940784663845949,"LOC101928574///LOC101060181///ZNF44","uncharacterized LOC101928574///zinc finger protein ZnFP12///zinc finger protein 44",TRUE
+"1562044_at",0.980953956539862,0.910414017191892,0.113809199073806,-5.93337674758394,0.0722531430823441,"LOC101928580","uncharacterized LOC101928580",TRUE
+"1562352_at",0.705559553212919,0.177509304104806,1.39276778065116,-5.0366154600731,1.1196431367228,"LOC101928583","uncharacterized LOC101928583",TRUE
+"1562353_x_at",0.971094654049796,0.861507932230185,-0.176495582323537,-5.92452250732493,-0.166482836829574,"LOC101928583","uncharacterized LOC101928583",TRUE
+"223202_s_at",0.65349309458318,0.12287936321075,-1.6039793604375,-4.75872756145156,-0.890086662510324,"LOC101928589///TMEM164","uncharacterized LOC101928589///transmembrane protein 164",TRUE
+"223201_s_at",0.731877674466364,0.215540819648055,-1.2749328809898,-5.1775537157075,-0.899513922367248,"LOC101928589///TMEM164","uncharacterized LOC101928589///transmembrane protein 164",TRUE
+"220486_x_at",0.747327586508411,0.239117490596765,-1.20976845845459,-5.25092985489846,-0.754961019428775,"LOC101928589///TMEM164","uncharacterized LOC101928589///transmembrane protein 164",TRUE
+"1560282_at",0.986455005400648,0.93706422912082,0.0798616525482796,-5.93657752620149,0.0466484652217884,"LOC101928590","uncharacterized LOC101928590",TRUE
+"1558525_at",0.896115372949367,0.577627140997005,0.565184142009171,-5.78528566770237,0.434165251999698,"LOC101928595","uncharacterized LOC101928595",TRUE
+"1569838_at",0.728671251879936,0.210134331876016,-1.29064031165932,-5.15937449418214,-1.10103342634669,"LOC101928597","uncharacterized LOC101928597",TRUE
+"1555890_at",0.898623566722697,0.588261214758275,-0.549347996656147,-5.79375536696396,-0.386872981296776,"LOC101928605///OR2A1-AS1///OR2A9P///OR2A20P","uncharacterized LOC101928605///OR2A1 antisense RNA 1///olfactory receptor family 2 subfamily A member 9 pseudogene///olfactory receptor family 2 subfamily A member 20 pseudogene",TRUE
+"1557511_at",0.813442508625161,0.363719362401791,0.927385149541112,-5.52925117095565,0.53671447206569,"LOC101928614","uncharacterized LOC101928614",TRUE
+"225032_at",0.331567148990739,0.0080716209475386,2.91040250990462,-2.48811784416538,1.41179327410069,"LOC101928615///FNDC3B","uncharacterized LOC101928615///fibronectin type III domain containing 3B",TRUE
+"222692_s_at",0.411110107932987,0.0161103726869261,2.60501537285621,-3.08461511231657,1.4021689675064,"LOC101928615///FNDC3B","uncharacterized LOC101928615///fibronectin type III domain containing 3B",TRUE
+"229865_at",0.49391164154523,0.0299734581919904,2.31944559228189,-3.61229959842708,1.41240923086414,"LOC101928615///FNDC3B","uncharacterized LOC101928615///fibronectin type III domain containing 3B",TRUE
+"222693_at",0.520481716530016,0.037754558532383,2.20974027238538,-3.80576279953222,1.31330540734311,"LOC101928615///FNDC3B","uncharacterized LOC101928615///fibronectin type III domain containing 3B",TRUE
+"218618_s_at",0.544577979658206,0.0466868102424055,2.10674080296129,-3.98215845624285,1.35655829702593,"LOC101928615///FNDC3B","uncharacterized LOC101928615///fibronectin type III domain containing 3B",TRUE
+"244429_at",0.709914655587487,0.182844889274547,1.37510601981554,-5.05840331815574,1.38055552368679,"LOC101928617","uncharacterized LOC101928617",TRUE
+"1561450_at",0.610033432202476,0.0824943678322339,-1.81874271535546,-4.44544483125461,-1.43074018652053,"LOC101928618","uncharacterized LOC101928618",TRUE
+"1562491_at",0.837337084923913,0.419890686374206,0.821900110719402,-5.61591216741661,0.799741381019103,"LOC101928622","uncharacterized LOC101928622",TRUE
+"202042_at",0.816800680706682,0.368990419464011,-0.917051350101297,-5.53816817637451,-0.27884409606482,"LOC101928623///HARS","uncharacterized LOC101928623///histidyl-tRNA synthetase",TRUE
+"1558859_at",0.829030239823335,0.400083935117856,-0.857990727933183,-5.5873558132827,-0.428567163740911,"LOC101928623///LOC401320","uncharacterized LOC101928623///uncharacterized LOC401320",TRUE
+"1558459_s_at",0.88330056907699,0.541255512533605,-0.620505651314783,-5.75387102364604,-0.25755004748865,"LOC101928623///LOC401320","uncharacterized LOC101928623///uncharacterized LOC401320",TRUE
+"1563781_at",0.897949253801113,0.585988261791968,-0.552720802549496,-5.79197105866153,-0.163112141791959,"LOC101928623///LOC401320","uncharacterized LOC101928623///uncharacterized LOC401320",TRUE
+"239640_at",0.910537143483061,0.627641954523815,0.491880294187149,-5.82252253197534,0.347279004238755,"LOC101928623///LOC401320","uncharacterized LOC101928623///uncharacterized LOC401320",TRUE
+"238540_at",0.912722788750542,0.63429900239112,-0.482334680005823,-5.8270007120071,-0.187012886404887,"LOC101928623///LOC401320","uncharacterized LOC101928623///uncharacterized LOC401320",TRUE
+"239313_at",0.933815609540291,0.70674793795932,-0.381114911036605,-5.86918481181983,-0.122974516241271,"LOC101928623///LOC401320","uncharacterized LOC101928623///uncharacterized LOC401320",TRUE
+"1558458_at",0.934081042629428,0.708445760079387,0.378794804276103,-5.8700376025366,0.374611456377187,"LOC101928623///LOC401320","uncharacterized LOC101928623///uncharacterized LOC401320",TRUE
+"209362_at",0.592518526795544,0.0696328078482424,1.9065323812153,-4.30917961515038,0.683417766459003,"LOC101928625///MED21","uncharacterized LOC101928625///mediator complex subunit 21",TRUE
+"209363_s_at",0.601886119917951,0.0770252222793537,1.85450329737328,-4.39048787833752,0.617349818596448,"LOC101928625///MED21","uncharacterized LOC101928625///mediator complex subunit 21",TRUE
+"1560957_at",0.923358263835948,0.670830156492655,0.430724038800955,-5.84972372937835,0.284695541963678,"LOC101928626","uncharacterized LOC101928626",TRUE
+"240918_at",0.8017109011727,0.339162902008753,-0.976904293756121,-5.48525061660751,-0.585655387682906,"LOC101928631///ZNF77","uncharacterized LOC101928631///zinc finger protein 77",TRUE
+"1560405_at",0.635916735157933,0.10711146874689,1.67945495283004,-4.65200212912255,0.73713613284395,"LOC101928632","uncharacterized LOC101928632",TRUE
+"211787_s_at",0.725181883744124,0.203846737471668,1.30930589564164,-5.13752591216345,0.335062495339859,"LOC101928634///SENP3-EIF4A1///SNORD10///SNORA48///SNORA67///EIF4A1","uncharacterized LOC101928634///SENP3-EIF4A1 readthrough (NMD candidate)///small nucleolar RNA, C/D box 10///small nucleolar RNA, H/ACA box 48///small nucleolar RNA, H/ACA box 67///eukaryotic translation initiation factor 4A1",TRUE
+"201530_x_at",0.83030603167465,0.40260908851771,0.853327138301321,-5.59111023801301,0.197200461139923,"LOC101928634///SENP3-EIF4A1///SNORD10///SNORA48///SNORA67///EIF4A1","uncharacterized LOC101928634///SENP3-EIF4A1 readthrough (NMD candidate)///small nucleolar RNA, C/D box 10///small nucleolar RNA, H/ACA box 48///small nucleolar RNA, H/ACA box 67///eukaryotic translation initiation factor 4A1",TRUE
+"203507_at",0.358427723880268,0.00996581846716865,2.81839318080066,-2.67086528335366,2.41077327569605,"LOC101928634///SNORA67///CD68","uncharacterized LOC101928634///small nucleolar RNA, H/ACA box 67///CD68 molecule",TRUE
+"240435_at",0.744307803443383,0.235251523192779,1.22010847280084,-5.23950845166614,0.407448249551865,"LOC101928635","uncharacterized LOC101928635",TRUE
+"207016_s_at",0.908224453443807,0.618801053384924,0.504629569854548,-5.81640773508532,0.362914272631251,"LOC101928635///ALDH1A2","uncharacterized LOC101928635///aldehyde dehydrogenase 1 family member A2",TRUE
+"243382_at",0.917102138198416,0.64957431261699,0.460600157507914,-5.836876767022,0.267829169031437,"LOC101928647","uncharacterized LOC101928647",TRUE
+"1556916_a_at",0.677013732819214,0.144379085494285,1.51313773137908,-4.88209126103962,0.889034511258453,"LOC101928651","uncharacterized LOC101928651",TRUE
+"1562630_at",0.895999830738594,0.576782086563148,0.566448820753599,-5.7845992086638,0.306168439801736,"LOC101928651","uncharacterized LOC101928651",TRUE
+"1556917_a_at",0.966064677476069,0.841818081651129,0.201924678439835,-5.91984366554139,0.128066797513703,"LOC101928651","uncharacterized LOC101928651",TRUE
+"1560383_at",0.840476743719991,0.429607746808278,-0.804586264883992,-5.62920367595515,-0.639006060896746,"LOC101928658","uncharacterized LOC101928658",TRUE
+"241218_at",0.87825255145971,0.530372981144887,0.637436584142791,-5.74369183669823,0.315680802430746,"LOC101928658","uncharacterized LOC101928658",TRUE
+"1560384_a_at",0.896115372949367,0.577663861100279,0.565129209116935,-5.78531545119063,0.376438630808172,"LOC101928658","uncharacterized LOC101928658",TRUE
+"1561314_at",0.967098323798013,0.846373312134784,-0.196030180880193,-5.92098401407993,-0.135215006234539,"LOC101928658","uncharacterized LOC101928658",TRUE
+"1561360_at",0.973066963106626,0.869482309439762,0.166231568604872,-5.92623345263384,0.0557995080358307,"LOC101928661","uncharacterized LOC101928661",TRUE
+"1557898_at",0.9611086798763,0.822409051190435,0.227125066189009,-5.91458912895032,0.133379215332769,"LOC101928663","uncharacterized LOC101928663",TRUE
+"1564729_at",0.836710575522201,0.418424152829045,0.824534894018492,-5.61386624585667,0.381996131742253,"LOC101928666","uncharacterized LOC101928666",TRUE
+"1561891_at",0.768852835478002,0.273617206850115,1.12261967434749,-5.34381239601046,0.578086333140711,"LOC101928668","uncharacterized LOC101928668",TRUE
+"215625_at",0.972112264314695,0.866245381825061,-0.170395628963735,-5.92555164991387,-0.11360554047112,"LOC101928669///LOC644450","uncharacterized LOC101928669///uncharacterized LOC644450",TRUE
+"229364_at",0.689985677226298,0.159430859586457,1.45595056176177,-4.95680252010456,0.779852443016956,"LOC101928673","uncharacterized LOC101928673",TRUE
+"237754_at",0.787781415608703,0.313554644811224,1.03123939922685,-5.43457703247682,0.361873782596407,"LOC101928682","uncharacterized LOC101928682",TRUE
+"1560241_at",0.994050962712312,0.972152295222173,0.0353054866360178,-5.9390763858077,0.0190290127939825,"LOC101928682","uncharacterized LOC101928682",TRUE
+"234473_at",0.703902004301726,0.175464296302573,1.39964912223749,-5.02806423118967,1.69701736381618,"LOC101928697","uncharacterized LOC101928697",TRUE
+"1569780_at",0.673582826047901,0.139878544251447,1.53118166026743,-4.858040054525,0.467716274801982,"LOC101928700","uncharacterized LOC101928700",TRUE
+"241124_at",0.789406360796076,0.3160586261018,1.02579299055468,-5.43976831947793,0.676609372590592,"LOC101928702","uncharacterized LOC101928702",TRUE
+"238031_at",0.585036027492332,0.0656105315995813,-1.93691114370325,-4.26098130134102,-1.68428271200883,"LOC101928707","uncharacterized LOC101928707",TRUE
+"1560812_at",0.930899509890345,0.694169042166469,-0.398371754497842,-5.8626807551553,-0.116751951965606,"LOC101928708","uncharacterized LOC101928708",TRUE
+"241394_at",0.0672685243895878,0.000161173785002945,4.53404574458009,0.952496071319846,3.20995493300038,"LOC101928710","uncharacterized LOC101928710",TRUE
+"1569403_at",0.93613089056626,0.714577503546221,-0.370433153872679,-5.87306843547835,-0.189504454911923,"LOC101928716","uncharacterized LOC101928716",TRUE
+"1557479_at",0.864079461576774,0.491118474708624,0.700153447309331,-5.70369756540079,0.310084261617706,"LOC101928718","uncharacterized LOC101928718",TRUE
+"241809_at",0.594972224548427,0.0717646110396257,-1.89105119961389,-4.33353779782503,-1.35884855578415,"LOC101928718///FAM212B","uncharacterized LOC101928718///family with sequence similarity 212 member B",TRUE
+"229608_at",0.835838027302116,0.41547998182905,-0.82984201540241,-5.60972663491754,-0.34958207440302,"LOC101928718///FAM212B","uncharacterized LOC101928718///family with sequence similarity 212 member B",TRUE
+"229382_at",0.872059365573905,0.514898904341665,-0.661839799730515,-5.72855710093663,-0.326679155530513,"LOC101928718///FAM212B","uncharacterized LOC101928718///family with sequence similarity 212 member B",TRUE
+"220476_s_at",0.99872918752906,0.994502723809105,0.00696802564875217,-5.93965983221481,0.00643894025862135,"LOC101928718///FAM212B","uncharacterized LOC101928718///family with sequence similarity 212 member B",TRUE
+"1560827_at",0.715352956634026,0.190999851358775,1.34888398669295,-5.09032403466278,0.473300725381391,"LOC101928725","uncharacterized LOC101928725",TRUE
+"1561422_at",0.784552021081681,0.307992544412303,1.04344800778268,-5.42285030777704,0.738947851529607,"LOC101928727","uncharacterized LOC101928727",TRUE
+"241668_s_at",0.835513930382091,0.414758412493461,0.831146323448647,-5.60870545687124,0.489011960584318,"LOC101928728","uncharacterized LOC101928728",TRUE
+"238094_at",0.934081042629428,0.708465964257528,0.378767207645428,-5.87004771519427,0.15087015371325,"LOC101928728","uncharacterized LOC101928728",TRUE
+"238139_at",0.984304383572197,0.923724881958654,0.0968389938125442,-5.93511693662458,0.0936460046944347,"LOC101928728","uncharacterized LOC101928728",TRUE
+"233466_at",0.878278790222455,0.530888449898445,-0.636630415980592,-5.74418249682124,-0.406710683439517,"LOC101928729","uncharacterized LOC101928729",TRUE
+"1570110_at",0.834881450121645,0.413644040412395,-0.833163481995604,-5.60712321543728,-0.625142147679815,"LOC101928730","uncharacterized LOC101928730",TRUE
+"242638_at",0.851733415458562,0.456592141511974,0.757737484674509,-5.66383211464328,0.602102442384869,"LOC101928731","uncharacterized LOC101928731",TRUE
+"1562190_at",0.908709061737317,0.620834913952119,0.501689144034786,-5.81783157039498,0.419078407576261,"LOC101928739","uncharacterized LOC101928739",TRUE
+"1561806_at",0.593339168375633,0.0703876098893451,1.90100409100647,-4.31789377062277,1.07762302327475,"LOC101928741","uncharacterized LOC101928741",TRUE
+"225310_at",0.6134063931611,0.0847212119195592,-1.80476889160738,-4.4667106803988,-0.551309527162928,"LOC101928747///RBMX///SNORD61","uncharacterized LOC101928747///RNA binding motif protein, X-linked///small nucleolar RNA, C/D box 61",TRUE
+"1556336_at",0.794426378358553,0.326289207880351,-1.0038491107888,-5.46043236772059,-0.473009223080831,"LOC101928747///RBMX///SNORD61","uncharacterized LOC101928747///RNA binding motif protein, X-linked///small nucleolar RNA, C/D box 61",TRUE
+"229999_at",0.829965377503324,0.40167743674651,0.855045572589651,-5.58972902978072,0.605137761047107,"LOC101928747///RBMX///SNORD61","uncharacterized LOC101928747///RNA binding motif protein, X-linked///small nucleolar RNA, C/D box 61",TRUE
+"213762_x_at",0.937856707467078,0.725038079942804,-0.356229902314735,-5.87806359632321,-0.0891417971213695,"LOC101928747///RBMX///SNORD61","uncharacterized LOC101928747///RNA binding motif protein, X-linked///small nucleolar RNA, C/D box 61",TRUE
+"1569816_at",0.725168361556674,0.203471886672577,1.3104327387515,-5.13619840786797,0.383026665542197,"LOC101928748","uncharacterized LOC101928748",TRUE
+"1555085_at",0.93178677872825,0.698855965145616,0.391927702215851,-5.86514269862213,0.313404230322624,"LOC101928751","uncharacterized LOC101928751",TRUE
+"1557768_at",0.972309558036541,0.866683964641375,-0.169831246660082,-5.92564504453628,-0.0582342449804676,"LOC101928760","uncharacterized LOC101928760",TRUE
+"236232_at",0.774230543658252,0.288555519757137,-1.08738287748373,-5.37962604970263,-0.307494758097226,"LOC101928762","uncharacterized LOC101928762",TRUE
+"243923_at",0.955816406528307,0.798815222543076,-0.257964532796517,-5.90732339918434,-0.232964761057451,"LOC101928767","uncharacterized LOC101928767",TRUE
+"1569807_at",0.80818658267298,0.349992040046361,0.954777186319101,-5.50517075444168,0.418632376206611,"LOC101928778","uncharacterized LOC101928778",TRUE
+"244800_x_at",0.899808883319249,0.593520062290548,-0.541569008320202,-5.79783020913855,-0.333879104600951,"LOC101928779","uncharacterized LOC101928779",TRUE
+"1555132_at",0.701308253942732,0.17305991700403,1.40782200141827,-5.01786287235234,0.851195679128661,"LOC101928787","uncharacterized LOC101928787",TRUE
+"1570206_at",0.922168942129244,0.667688745173762,0.435113780611167,-5.84788908015325,0.299707909256,"LOC101928797","uncharacterized LOC101928797",TRUE
+"241416_at",0.759576632581869,0.257183085879673,1.16304891543843,-5.30147962158827,0.954781171425762,"LOC101928806","uncharacterized LOC101928806",TRUE
+"1560791_at",0.998870448604467,0.996230743415423,0.00477766769327003,-5.93967236299931,0.00403748507945467,"LOC101928809","uncharacterized LOC101928809",TRUE
+"242199_at",0.94895689004559,0.768845861221905,-0.297513853831021,-5.8966630544699,-0.132646888847145,"LOC101928812","uncharacterized LOC101928812",TRUE
+"1563370_at",0.8289434059415,0.399912727422225,0.858307606789017,-5.58710001837337,0.366980408069824,"LOC101928813","uncharacterized LOC101928813",TRUE
+"1556004_at",0.495672562291005,0.0302186647841433,-2.31560931992872,-3.61915751305044,-1.22861299060293,"LOC101928817","uncharacterized LOC101928817",TRUE
+"1556003_a_at",0.932091525948902,0.700083287108588,-0.390243055070851,-5.86577979409213,-0.213142053179148,"LOC101928817","uncharacterized LOC101928817",TRUE
+"1569819_at",0.680328558865778,0.147500955405486,-1.50089015525129,-4.89828657084092,-1.00801439398112,"LOC101928818///PWRN1","uncharacterized LOC101928818///Prader-Willi region non-protein coding RNA 1",TRUE
+"1556263_s_at",0.936992192746977,0.717861452330237,-0.365966019978588,-5.87466026917929,-0.17067766790899,"LOC101928818///PWRN1","uncharacterized LOC101928818///Prader-Willi region non-protein coding RNA 1",TRUE
+"1556262_at",0.975475861996229,0.883152051894401,0.148678709414055,-5.92892250748386,0.0844528771069664,"LOC101928818///PWRN1","uncharacterized LOC101928818///Prader-Willi region non-protein coding RNA 1",TRUE
+"1562873_at",0.99659046136788,0.982973468574611,-0.0215834037101032,-5.93945658819262,-0.0169930736113977,"LOC101928818///PWRN1","uncharacterized LOC101928818///Prader-Willi region non-protein coding RNA 1",TRUE
+"234219_at",0.468735421183467,0.0249658045690141,2.40486791970125,-3.45793089218039,0.786224801539498,"LOC101928820","uncharacterized LOC101928820",TRUE
+"1561592_at",0.462669793287247,0.0234317815749865,2.43422183892051,-3.40417028158235,1.75706946914491,"LOC101928823","uncharacterized LOC101928823",TRUE
+"211943_x_at",0.900376038169601,0.595293889415508,0.538952758117819,-5.79918797753337,0.119881896993984,"LOC101928826///TPT1","uncharacterized LOC101928826///tumor protein, translationally-controlled 1",TRUE
+"212869_x_at",0.933609099853387,0.706222838939252,0.381832899895972,-5.86891986360603,0.0891126218749694,"LOC101928826///TPT1","uncharacterized LOC101928826///tumor protein, translationally-controlled 1",TRUE
+"212284_x_at",0.96357296999255,0.834039155096432,0.212007728647248,-5.91781500094413,0.0458272954990555,"LOC101928826///TPT1","uncharacterized LOC101928826///tumor protein, translationally-controlled 1",TRUE
+"216520_s_at",0.969642324744141,0.855031141698291,0.184846269250564,-5.9230551274764,0.0429384564654747,"LOC101928826///TPT1","uncharacterized LOC101928826///tumor protein, translationally-controlled 1",TRUE
+"214327_x_at",0.998495910561622,0.993674002766158,-0.00801848594166051,-5.9396521645297,-0.00167949536990974,"LOC101928826///TPT1","uncharacterized LOC101928826///tumor protein, translationally-controlled 1",TRUE
+"208771_s_at",0.770065918069802,0.278674426244702,1.11053758763733,-5.35620647031489,0.417572533250679,"LOC101928830///LTA4H","uncharacterized LOC101928830///leukotriene A4 hydrolase",TRUE
+"1562107_at",0.90998880119877,0.625217934564194,-0.49536761685258,-5.82086512484213,-0.379312293725346,"LOC101928833","uncharacterized LOC101928833",TRUE
+"1569954_at",0.756584150514497,0.251918009452586,1.17640486465953,-5.28720608145454,0.816271439601579,"LOC101928834","uncharacterized LOC101928834",TRUE
+"1557147_a_at",0.985236171081115,0.926509427934277,-0.0932927894004205,-5.9354451940316,-0.0627150166100199,"LOC101928837","uncharacterized LOC101928837",TRUE
+"1556114_a_at",0.812302873476553,0.358948752955957,-0.936824483060989,-5.52102569212581,-0.489458582250595,"LOC101928841","collagen alpha-1(II) chain-like",TRUE
+"1556113_at",0.851319596585235,0.454793750836634,0.760806531323828,-5.66162363329217,0.304414430281963,"LOC101928841","collagen alpha-1(II) chain-like",TRUE
+"1569961_at",0.643515428391208,0.114116750648986,-1.64484283386784,-4.70141181297859,-0.537902803345741,"LOC101928844","uncharacterized LOC101928844",TRUE
+"1560576_at",0.78885145722244,0.31512413163002,1.02782205199856,-5.43783720328594,0.468417132206184,"LOC101928845","uncharacterized LOC101928845",TRUE
+"1562699_at",0.698448740076777,0.169722724474807,-1.4193173733306,-5.0034316698458,-1.39791030008981,"LOC101928847","uncharacterized LOC101928847",TRUE
+"1561062_a_at",0.734861913384601,0.219870381346865,-1.26257157126416,-5.19172661655886,-0.814183617524,"LOC101928850","uncharacterized LOC101928850",TRUE
+"1570262_at",0.960278309202107,0.820017082365563,-0.230240859549234,-5.91389678136439,-0.175823787885395,"LOC101928851","uncharacterized LOC101928851",TRUE
+"1559321_at",0.983498417373669,0.91946736457023,-0.102263549140847,-5.93459113897067,-0.0744338115417333,"LOC101928858","uncharacterized LOC101928858",TRUE
+"1561512_at",0.871491894918955,0.512917013015035,-0.664994398047341,-5.72656083692425,-0.45524859292272,"LOC101928861","uncharacterized LOC101928861",TRUE
+"1561469_at",0.786455312223125,0.31218228451307,1.0342374026469,-5.43170888227725,0.771544153950556,"LOC101928865","uncharacterized LOC101928865",TRUE
+"1557631_at",0.975398143273847,0.882237549831427,0.14985143687198,-5.92875217229491,0.118162859945272,"LOC101928877","uncharacterized LOC101928877",TRUE
+"223198_x_at",0.96635324070119,0.843311079906298,0.199991933048327,-5.92022128226087,0.0767065979181094,"LOC101928879///ZNF250///COMMD5","COMM domain-containing protein 5-like///zinc finger protein 250///COMM domain containing 5",TRUE
+"223819_x_at",0.985673230154868,0.930742341590041,-0.0879043757306174,-5.93592055732668,-0.0352306714864756,"LOC101928879///ZNF250///COMMD5","COMM domain-containing protein 5-like///zinc finger protein 250///COMM domain containing 5",TRUE
+"233486_at",0.791348540995396,0.321793362815741,1.01343235308249,-5.45145778567211,0.341716188022898,"LOC101928881","uncharacterized LOC101928881",TRUE
+"233326_at",0.62110896023334,0.0917097744888773,1.76288294598981,-4.52973858168095,1.5122439691604,"LOC101928882///CCDC39","uncharacterized LOC101928882///coiled-coil domain containing 39",TRUE
+"1562786_at",0.976371465776674,0.886727134538516,0.144096172631426,-5.92957530208418,0.05844824139067,"LOC101928886","uncharacterized LOC101928886",TRUE
+"1569955_at",0.915569510513076,0.643958809587076,-0.468563485030106,-5.83331000390418,-0.474409976850975,"LOC101928893","uncharacterized LOC101928893",TRUE
+"1563086_at",0.64484773720849,0.115323661169174,1.63906148743492,-4.70958818770987,0.655787603057191,"LOC101928894","uncharacterized LOC101928894",TRUE
+"1556272_a_at",0.819193107051406,0.375742261147843,0.90395680749695,-5.54933503878416,0.66116998859259,"LOC101928896","uncharacterized LOC101928896",TRUE
+"1556271_at",0.864894115958506,0.493652887553644,0.696020739272491,-5.70644332502374,0.686064101955576,"LOC101928896","uncharacterized LOC101928896",TRUE
+"1569978_x_at",0.854040699678541,0.462893885783415,0.747040068599315,-5.67146390076253,0.417158063964828,"LOC101928902","uncharacterized LOC101928902",TRUE
+"1570537_a_at",0.895366192695711,0.573705785618817,0.571060619193636,-5.78208335599348,0.334927355094293,"LOC101928902","uncharacterized LOC101928902",TRUE
+"1561424_at",0.870517518639056,0.509537059136441,0.670390017921028,-5.72312535329005,0.592025789355592,"LOC101928907","uncharacterized LOC101928907",TRUE
+"1563297_s_at",0.975550833930114,0.883440559267825,0.148308781394486,-5.92897596136987,0.075932798819105,"LOC101928907","uncharacterized LOC101928907",TRUE
+"1568722_at",0.927217810817605,0.681757351855117,-0.415520719015577,-5.85593649596515,-0.368820029149444,"LOC101928909","uncharacterized LOC101928909",TRUE
+"1570397_x_at",0.743474458360704,0.233859601918379,-1.2238627926675,-5.23534068314981,-1.10004492081245,"LOC101928910///FAM66C","uncharacterized LOC101928910///family with sequence similarity 66 member C",TRUE
+"1570396_at",0.884729701742031,0.544065000267924,-0.616164384566362,-5.75643855854553,-0.521226453086456,"LOC101928910///FAM66C","uncharacterized LOC101928910///family with sequence similarity 66 member C",TRUE
+"1570395_a_at",0.989143673229517,0.947207961578013,0.0669678071902386,-5.93749939100959,0.0503510812334858,"LOC101928910///FAM66C","uncharacterized LOC101928910///family with sequence similarity 66 member C",TRUE
+"202237_at",0.554642754132296,0.0509555824008453,2.06366957789582,-4.05433135132593,3.35935917042565,"LOC101928916///NNMT","uncharacterized LOC101928916///nicotinamide N-methyltransferase",TRUE
+"202238_s_at",0.585036027492332,0.065629166089965,1.93676667011769,-4.26121176417722,3.18086383905869,"LOC101928916///NNMT","uncharacterized LOC101928916///nicotinamide N-methyltransferase",TRUE
+"231589_at",0.986128804248552,0.931857902154653,0.0864847401867145,-5.93604109487753,0.0600791877499711,"LOC101928917","heat shock transcription factor, X-linked-like",TRUE
+"1554957_at",0.62932992642067,0.100202936829575,-1.71551972979679,-4.59969240114341,-0.855382695632217,"LOC101928921","uncharacterized LOC101928921",TRUE
+"225699_at",0.659870891937597,0.127689694315497,-1.58257246500879,-4.78830652295593,-0.569231957023058,"LOC101928927///SNORA9///SNHG15","uncharacterized LOC101928927///small nucleolar RNA, H/ACA box 9///small nucleolar RNA host gene 15",TRUE
+"1568832_a_at",0.932269331146744,0.701247619991693,-0.38864593002006,-5.86638129337572,-0.248265124105117,"LOC101928933","uncharacterized LOC101928933",TRUE
+"1562984_at",0.910271599367218,0.627059341903372,-0.49271790533509,-5.82212548722743,-0.240317647261037,"LOC101928937","uncharacterized LOC101928937",TRUE
+"1569753_at",0.790016508699375,0.319171004310206,1.01906529088581,-5.44614659986773,0.32605450564705,"LOC101928940","uncharacterized LOC101928940",TRUE
+"240986_at",0.636486087950469,0.107728253459417,-1.6763319513259,-4.65649237703512,-1.28275318242846,"LOC101928943","uncharacterized LOC101928943",TRUE
+"235826_at",0.970271320001985,0.858612478749996,-0.180227138755485,-5.92387515532533,-0.0905727755724621,"LOC101928954","uncharacterized LOC101928954",TRUE
+"1560285_at",0.728385463227073,0.209161169493147,1.29350070577371,-5.15604359682864,0.917684615302801,"LOC101928955","uncharacterized LOC101928955",TRUE
+"1560286_s_at",0.868361060481977,0.502896101443325,0.681050105389893,-5.71625979472887,0.664779914978935,"LOC101928955","uncharacterized LOC101928955",TRUE
+"1561216_at",0.56861088242915,0.0583423188228347,1.99623361688784,-4.16536289643726,1.28805417093128,"LOC101928961","uncharacterized LOC101928961",TRUE
+"235607_at",0.960278309202107,0.819974510402747,-0.230296335071461,-5.913884369338,-0.104649336447311,"LOC101928963","uncharacterized LOC101928963",TRUE
+"1565585_at",0.970684983385094,0.860256806034289,-0.178107670960402,-5.9242444980542,-0.124743681721876,"LOC101928968","uncharacterized LOC101928968",TRUE
+"1561045_a_at",0.735742230654287,0.220911990909663,1.25962559682984,-5.1950868985097,0.86492803169361,"LOC101928973","uncharacterized LOC101928973",TRUE
+"1561044_at",0.910165867297668,0.626825187824852,-0.49305464489607,-5.82196567984102,-0.133706876906216,"LOC101928973","uncharacterized LOC101928973",TRUE
+"1563165_at",0.819723837900625,0.377041222691015,0.901455483210803,-5.55145126525185,0.732521583694076,"LOC101928978","uncharacterized LOC101928978",TRUE
+"1561107_at",0.783598827774051,0.306186934212155,1.04744472128154,-5.41898436401089,0.743803805074155,"LOC101928985","uncharacterized LOC101928985",TRUE
+"1560257_at",0.662015916975184,0.130016773601481,1.5724563653858,-4.8021763788929,0.701509999140633,"LOC101928988","uncharacterized LOC101928988",TRUE
+"1561516_at",0.617775129514679,0.0886722211373087,1.78073838762605,-4.50300269089068,1.09883799562179,"LOC101928995","uncharacterized LOC101928995",TRUE
+"1562885_at",0.593337376134677,0.0700216520356775,1.90367789872346,-4.31368129217066,1.05307308504861,"LOC101929002","uncharacterized LOC101929002",TRUE
+"241439_at",0.997654912087849,0.988440566701626,0.0146524853241163,-5.93957891111247,0.01195975793719,"LOC101929004","uncharacterized LOC101929004",TRUE
+"1568894_at",0.774230543658252,0.289116320517312,1.08608602214002,-5.38092474614333,0.291139378386284,"LOC101929007","WAS/WASL-interacting protein family member 1",TRUE
+"1563287_at",0.992816117752561,0.966004359283249,-0.0431044666187027,-5.93877856038613,-0.0259868482794632,"LOC101929019","uncharacterized LOC101929019",TRUE
+"240944_at",0.89967769475675,0.591250589061559,-0.544921883679228,-5.7960808075442,-0.41722171462323,"LOC101929027","uncharacterized LOC101929027",TRUE
+"240817_at",0.909052380289506,0.622792157573724,0.498863712536766,-5.8191920709357,0.344777778312737,"LOC101929034","uncharacterized LOC101929034",TRUE
+"242375_x_at",0.623667408398064,0.0950912103340387,1.74359369325197,-4.55839848364565,0.56850561467166,"LOC101929036///PAH","uncharacterized LOC101929036///phenylalanine hydroxylase",TRUE
+"244742_at",0.768852835478002,0.274026040084938,-1.1216369178346,-5.34482496582844,-0.704185078867079,"LOC101929036///PAH","uncharacterized LOC101929036///phenylalanine hydroxylase",TRUE
+"217583_at",0.821896104057596,0.384921664079769,-0.886400808692419,-5.56407354704849,-0.577642137375153,"LOC101929036///PAH","uncharacterized LOC101929036///phenylalanine hydroxylase",TRUE
+"209986_at",0.872540606821582,0.515854271457944,0.660321541068533,-5.72951462811377,0.497747294067941,"LOC101929036///PAH","uncharacterized LOC101929036///phenylalanine hydroxylase",TRUE
+"205719_s_at",0.890816525789205,0.559743973360551,-0.592151462388172,-5.77032611537086,-0.506412249286664,"LOC101929036///PAH","uncharacterized LOC101929036///phenylalanine hydroxylase",TRUE
+"222461_s_at",0.677013732819214,0.144395997550744,1.51307080149816,-4.88218005024414,0.783247075707924,"LOC101929047///HERC2","uncharacterized LOC101929047///HECT and RLD domain containing E3 ubiquitin protein ligase 2",TRUE
+"216830_at",0.678126513742682,0.145366125295039,-1.50924219770939,-4.88725385222171,-0.949490198234771,"LOC101929047///HERC2P10///HERC2","uncharacterized LOC101929047///hect domain and RLD 2 pseudogene 10///HECT and RLD domain containing E3 ubiquitin protein ligase 2",TRUE
+"240427_at",0.61760967235709,0.0880094092509883,1.7847043720815,-4.49703747831878,1.14578646447747,"LOC101929050","uncharacterized LOC101929050",TRUE
+"1559220_at",0.700061364939874,0.171646734121079,-1.41266804603981,-5.01179095325779,-0.66337563464883,"LOC101929054","uncharacterized LOC101929054",TRUE
+"1559344_at",0.927934056345262,0.683733466469357,0.412782001531524,-5.8570323284106,0.298943709641244,"LOC101929064","uncharacterized LOC101929064",TRUE
+"230937_at",0.90427866743639,0.606753184426057,0.522141548744798,-5.80775992606411,0.362501557864285,"LOC101929072///LOC285835","uncharacterized LOC101929072///uncharacterized LOC285835",TRUE
+"1563771_a_at",0.821424121108148,0.383368379544087,0.889352077849317,-5.56161462554384,0.784752760628118,"LOC101929073","uncharacterized LOC101929073",TRUE
+"1570405_at",0.854040699678541,0.463212435617899,0.746501636934872,-5.67184531395,0.425253211997686,"LOC101929076","uncharacterized LOC101929076",TRUE
+"210921_at",0.998347572104896,0.992748398663098,0.00919176309160178,-5.93964232959533,0.00508838952377122,"LOC101929078","myb-related transcription factor, partner of profilin-like",TRUE
+"1557848_at",0.915569510513076,0.644137815535398,0.468309164913247,-5.83342483896088,0.246434787835686,"LOC101929084","uncharacterized LOC101929084",TRUE
+"208738_x_at",0.778291838199375,0.29778606318695,-1.06626327553565,-5.40060329131368,-0.282837917872017,"LOC101929087///SUMO2///SUMO3","small ubiquitin-related modifier 2 pseudogene///small ubiquitin-like modifier 2///small ubiquitin-like modifier 3",TRUE
+"213881_x_at",0.822232806605564,0.386903453873603,0.882646647077822,-5.56719047039226,0.181856206126795,"LOC101929087///SUMO2///SUMO3","small ubiquitin-related modifier 2 pseudogene///small ubiquitin-like modifier 2///small ubiquitin-like modifier 3",TRUE
+"208739_x_at",0.962792962312845,0.830675808757096,0.216374209226772,-5.91690594955924,0.0653638655273738,"LOC101929087///SUMO2///SUMO3","small ubiquitin-related modifier 2 pseudogene///small ubiquitin-like modifier 2///small ubiquitin-like modifier 3",TRUE
+"244301_at",0.785440072877511,0.310969357850622,1.03689485039416,-5.42916026338816,0.348820794744827,"LOC101929089","uncharacterized LOC101929089",TRUE
+"243728_at",0.51531387545335,0.0358462109575443,-2.23458833125741,-3.76243404291458,-1.44471675615898,"LOC101929109","uncharacterized LOC101929109",TRUE
+"1557664_at",0.864837421576847,0.492822816576926,-0.697372942104545,-5.70554663216818,-0.269412003797719,"LOC101929114","uncharacterized LOC101929114",TRUE
+"220546_at",0.794886978929048,0.327070367900627,1.00219338730674,-5.4619750998861,0.779340874412571,"LOC101929115///KMT2A","uncharacterized LOC101929115///lysine methyltransferase 2A",TRUE
+"1569782_at",0.960145170887792,0.819657537287383,-0.230709405966811,-5.9137918558076,-0.0928666800999736,"LOC101929116","uncharacterized LOC101929116",TRUE
+"240460_at",0.896428361916712,0.580897524600246,0.560298540491771,-5.78792356111251,0.419968848589686,"LOC101929122","uncharacterized LOC101929122",TRUE
+"1561454_at",0.774011928861764,0.28578561726348,1.09381508256954,-5.37316430573613,0.31683957524202,"LOC101929123","uncharacterized LOC101929123",TRUE
+"1559252_a_at",0.697589104334815,0.168107803446306,1.42494527476958,-4.99633130829281,0.684537509868998,"LOC101929125","uncharacterized LOC101929125",TRUE
+"1557099_at",0.838616623280672,0.423810076229872,0.814886731101382,-5.62132818318303,0.517002756436588,"LOC101929132","uncharacterized LOC101929132",TRUE
+"1562922_at",0.840879524142924,0.430521088602339,-0.802971472018293,-5.63042977871543,-0.496627076401289,"LOC101929133","uncharacterized LOC101929133",TRUE
+"1554290_at",0.713330901550199,0.188070527437511,1.35819961868556,-5.07904263099023,1.03653326735107,"LOC101929134///HERC3","uncharacterized LOC101929134///HECT and RLD domain containing E3 ubiquitin protein ligase 3",TRUE
+"206183_s_at",0.808257777979515,0.350421332050855,-0.953909678277043,-5.50594323482925,-0.45138951051753,"LOC101929134///HERC3","uncharacterized LOC101929134///HECT and RLD domain containing E3 ubiquitin protein ligase 3",TRUE
+"1557366_at",0.578925607036084,0.0618665090087125,1.96670001688019,-4.21321130081799,1.95364242326024,"LOC101929141///CCDC144CP///CCDC144B///CCDC144A","coiled-coil domain-containing protein 144B-like///coiled-coil domain containing 144C, pseudogene///coiled-coil domain containing 144B (pseudogene)///coiled-coil domain containing 144A",TRUE
+"1560787_at",0.992816117752561,0.966014714588233,-0.0430913282051981,-5.93877911192405,-0.0358149175636422,"LOC101929143","uncharacterized LOC101929143",TRUE
+"1570127_at",0.741260241503758,0.231768528224437,1.22953482883095,-5.22902302834703,0.630425427980179,"LOC101929144","uncharacterized LOC101929144",TRUE
+"1562474_at",0.774011928861764,0.285688964660429,1.09404033793315,-5.37293740085726,0.485340024437408,"LOC101929147","uncharacterized LOC101929147",TRUE
+"1561553_at",0.905462783815257,0.611419269563857,0.515339907762793,-5.8111528817591,0.50269776518496,"LOC101929147","uncharacterized LOC101929147",TRUE
+"216664_at",0.61299046462692,0.0845821009347026,-1.80563247711775,-4.4653998829221,-1.31356741677356,"LOC101929148","uncharacterized LOC101929148",TRUE
+"216665_s_at",0.931370027472813,0.6962572420998,0.395498583334256,-5.86378333278163,0.330743516853066,"LOC101929148","uncharacterized LOC101929148",TRUE
+"1561673_at",0.759953489670063,0.257793459038147,1.1615137532629,-5.30311110430805,0.894588977571982,"LOC101929151","uncharacterized LOC101929151",TRUE
+"1557787_at",0.895690630367785,0.575572252011438,0.568261043311144,-5.78361295377148,0.447221196858261,"LOC101929153","uncharacterized LOC101929153",TRUE
+"244138_at",0.936992192746977,0.718697640053998,-0.364829773758345,-5.87506212179373,-0.173321872672454,"LOC101929154","uncharacterized LOC101929154",TRUE
+"1565839_a_at",0.571677937624457,0.0593986999898128,1.9872186255233,-4.18001939485216,1.71317700563711,"LOC101929162","uncharacterized LOC101929162",TRUE
+"1565838_at",0.747780646916362,0.239686435065555,1.20825741530613,-5.25259187165029,0.738815515743052,"LOC101929162","uncharacterized LOC101929162",TRUE
+"234831_at",0.719965488428987,0.195740459356297,1.33404346302006,-5.10816176184689,1.03160167778691,"LOC101929164","uncharacterized LOC101929164",TRUE
+"215597_x_at",0.955645941042265,0.796798811037455,-0.260611645688373,-5.90665695321825,-0.221530656829106,"LOC101929165","uncharacterized LOC101929165",TRUE
+"1563371_at",0.826617572584789,0.394895263820118,0.867633206870319,-5.57953274005267,0.469533747218612,"LOC101929167","uncharacterized LOC101929167",TRUE
+"1562078_at",0.813065886130395,0.362632343393971,0.929528642670345,-5.52739004227727,0.278166272394865,"LOC101929172","uncharacterized LOC101929172",TRUE
+"1563376_at",0.85042566396989,0.453005855544018,0.76386491925773,-5.65941442606053,0.623976955659246,"LOC101929174","uncharacterized LOC101929174",TRUE
+"232899_at",0.910165867297668,0.626737454808859,0.493180829597712,-5.82190576856301,0.144382350298702,"LOC101929177","uncharacterized LOC101929177",TRUE
+"234506_at",0.975552150564853,0.883577785562153,0.148132835440908,-5.92900133859015,0.0720468798159999,"LOC101929180","uncharacterized LOC101929180",TRUE
+"1561732_at",0.773642533214642,0.284991938938749,1.09566643555872,-5.37129816187147,0.8061891512607,"LOC101929181","uncharacterized LOC101929181",TRUE
+"232827_at",0.948989397056643,0.77001619851496,0.295960703757217,-5.89711010954203,0.176362649022543,"LOC101929188","uncharacterized LOC101929188",TRUE
+"1570268_at",0.707818577910656,0.179456444938226,1.38627414250237,-5.04465291924683,1.2030400871426,"LOC101929210","uncharacterized LOC101929210",TRUE
+"230381_at",0.808257777979515,0.350713101542527,0.953320485179287,-5.50646752055808,0.855156115248609,"LOC101929219///C1orf186","uncharacterized LOC101929219///chromosome 1 open reading frame 186",TRUE
+"222334_at",0.748924337581408,0.242055680803058,1.20199389671354,-5.25946197316557,0.879071785192005,"LOC101929219///LOC100505650///C1orf186","uncharacterized LOC101929219///uncharacterized LOC100505650///chromosome 1 open reading frame 186",TRUE
+"222281_s_at",0.924066272872542,0.673305023844468,-0.427271763836098,-5.8511537367722,-0.619325667178122,"LOC101929219///LOC100505650///C1orf186","uncharacterized LOC101929219///uncharacterized LOC100505650///chromosome 1 open reading frame 186",TRUE
+"1561741_at",0.72050514215489,0.196574539330633,1.33146159481819,-5.11124814081935,1.24141206002354,"LOC101929224","uncharacterized LOC101929224",TRUE
+"244135_at",0.870684240983489,0.509911027809278,-0.669792047901808,-5.72350740105767,-0.291601263362352,"LOC101929229","uncharacterized LOC101929229",TRUE
+"217520_x_at",0.315093142651413,0.00677929926050567,2.98590711197771,-2.33642094783643,1.72173349931458,"LOC101929232///PDCD6IPP2","uncharacterized LOC101929232///PDCD6IP pseudogene 2",TRUE
+"214982_at",0.77547560202111,0.292455837809945,1.0784006116859,-5.38859268479488,0.411508837155184,"LOC101929240///SNRNP200","U5 small nuclear ribonucleoprotein 200 kDa helicase pseudogene///small nuclear ribonucleoprotein U5 subunit 200",TRUE
+"200058_s_at",0.952416163126023,0.782340397577337,-0.279649530879173,-5.9016648824482,-0.0749478367943315,"LOC101929240///SNRNP200","U5 small nuclear ribonucleoprotein 200 kDa helicase pseudogene///small nuclear ribonucleoprotein U5 subunit 200",TRUE
+"217114_at",0.965380895563592,0.838510430824702,-0.206209379139832,-5.91899362908367,-0.0809937906065485,"LOC101929240///SNRNP200","U5 small nuclear ribonucleoprotein 200 kDa helicase pseudogene///small nuclear ribonucleoprotein U5 subunit 200",TRUE
+"1563007_at",0.831487912516861,0.406012601907126,0.847070896344298,-5.59611686882044,0.589809031399349,"LOC101929241","uncharacterized LOC101929241",TRUE
+"229444_at",0.849935057946582,0.452474800761795,-0.764774747848007,-5.65875560043067,-0.304856023331844,"LOC101929243","uncharacterized LOC101929243",TRUE
+"1560212_a_at",0.991754150288374,0.961729100114476,0.0485294435695819,-5.93853646011341,0.0314901997570631,"LOC101929248","uncharacterized LOC101929248",TRUE
+"242412_at",0.65284137151906,0.122202025436158,1.60704952140719,-4.75446003929086,1.31913099642428,"LOC101929255","uncharacterized LOC101929255",TRUE
+"1562463_at",0.757361197594703,0.253165355850945,1.17322208193834,-5.29062047225198,0.541882911860109,"LOC101929260","uncharacterized LOC101929260",TRUE
+"1560298_at",0.953931868692178,0.787434709315345,0.272929994371384,-5.90346675387593,0.154003707007463,"LOC101929261","uncharacterized LOC101929261",TRUE
+"1563993_at",0.83592051541604,0.415689856308124,0.829462915068063,-5.61002316141767,0.483523273491715,"LOC101929268","uncharacterized LOC101929268",TRUE
+"1563274_at",0.315813954242496,0.00681592073170819,2.98358398982567,-2.34111036537367,1.58988579010033,"LOC101929269","uncharacterized LOC101929269",TRUE
+"215565_at",0.823476629980596,0.39031361437489,-0.876215909564132,-5.57250112751353,-0.560034245830431,"LOC101929272","uncharacterized LOC101929272",TRUE
+"1562643_at",0.707829100323006,0.17948723517074,1.38617190904057,-5.04477920930098,0.969298511614479,"LOC101929279","uncharacterized LOC101929279",TRUE
+"1569396_at",0.963893166630148,0.834898081120631,-0.210893302735735,-5.918044056145,-0.0615027426004087,"LOC101929280","uncharacterized LOC101929280",TRUE
+"1561572_at",0.923376218980614,0.671142672890238,-0.430287806505878,-5.84990505025937,-0.422473174889944,"LOC101929284","uncharacterized LOC101929284",TRUE
+"1562760_at",0.938726197187622,0.726920022487411,0.353682614490964,-5.87893905916982,0.153586787859964,"LOC101929288","uncharacterized LOC101929288",TRUE
+"240142_at",0.985498770484702,0.930041310060315,0.0887965861174545,-5.93584379854532,0.0611898514067253,"LOC101929289","uncharacterized LOC101929289",TRUE
+"1562847_at",0.610059565135779,0.0826355946848757,-1.81784685634724,-4.44681172944534,-1.3859906051828,"LOC101929297","uncharacterized LOC101929297",TRUE
+"237203_at",0.848364007856994,0.4482528496525,0.772031084158947,-5.65347462545241,0.409125808030728,"LOC101929305","uncharacterized LOC101929305",TRUE
+"233016_at",0.91676531736797,0.64822118430562,-0.462516241826394,-5.83602402638639,-0.241140916944291,"LOC101929305","uncharacterized LOC101929305",TRUE
+"1561474_at",0.984473578298083,0.924279793711883,0.0961321967068521,-5.93518333808922,0.0795219055706928,"LOC101929312","uncharacterized LOC101929312",TRUE
+"231620_at",0.769964459532824,0.278553214623855,-1.11082529597151,-5.35591271434941,-0.757864755131295,"LOC101929315","uncharacterized LOC101929315",TRUE
+"1562690_at",0.70628982896028,0.178347936758321,1.38996406457435,-5.04008955634318,1.07539980440478,"LOC101929319","uncharacterized LOC101929319",TRUE
+"233527_at",0.839045421044582,0.424803157897561,0.813116157308161,-5.62268861202225,0.372561918723674,"LOC101929340","uncharacterized LOC101929340",TRUE
+"237738_at",0.96635324070119,0.843341429862327,0.199952651934848,-5.92022891943169,0.151047460804698,"LOC101929341","uncharacterized LOC101929341",TRUE
+"226617_at",0.823736995840224,0.390826395288018,-0.875252092889679,-5.57329396460564,-0.265756906734765,"LOC101929356///ARL5A","uncharacterized LOC101929356///ADP ribosylation factor like GTPase 5A",TRUE
+"243176_at",0.937113154905832,0.719911458749782,0.363181256891518,-5.87564295414125,0.145630218212218,"LOC101929356///ARL5A","uncharacterized LOC101929356///ADP ribosylation factor like GTPase 5A",TRUE
+"218150_at",0.969450447163359,0.854513918967042,0.185513709683263,-5.92293492746057,0.0578120959791377,"LOC101929356///ARL5A","uncharacterized LOC101929356///ADP ribosylation factor like GTPase 5A",TRUE
+"210187_at",0.853017083148173,0.459373296684313,0.75300556006829,-5.66722064943127,0.486152787002032,"LOC101929368///FKBP1A","uncharacterized LOC101929368///FK506 binding protein 1A",TRUE
+"214119_s_at",0.943360471261283,0.745888855466397,0.328136985409261,-5.88737514846187,0.155714061459573,"LOC101929368///FKBP1A","uncharacterized LOC101929368///FK506 binding protein 1A",TRUE
+"210186_s_at",0.985361089461736,0.927388063942272,0.0921740761368755,-5.93554621008377,0.0441524538199562,"LOC101929368///FKBP1A","uncharacterized LOC101929368///FK506 binding protein 1A",TRUE
+"200709_at",0.985425981490741,0.929041964445586,0.0900685919267164,-5.93573302584397,0.0401051223650324,"LOC101929368///FKBP1A","uncharacterized LOC101929368///FK506 binding protein 1A",TRUE
+"1569793_at",0.990810941805126,0.956245498940445,0.0554899228061389,-5.93818386058343,0.0325929125047919,"LOC101929372","uncharacterized LOC101929372",TRUE
+"1553633_s_at",0.682825347106105,0.150839218196619,1.48802568491726,-4.91518388776846,0.98824128900642,"LOC101929373///SLC9B1","uncharacterized LOC101929373///solute carrier family 9 member B1",TRUE
+"1555141_a_at",0.839519981963042,0.427291300412626,-0.808691342311832,-5.62607630047566,-0.390347900618465,"LOC101929373///SLC9B1","uncharacterized LOC101929373///solute carrier family 9 member B1",TRUE
+"1555142_at",0.945272089973488,0.752977200370977,0.318648784584785,-5.89034917448601,0.221568685975258,"LOC101929373///SLC9B1","uncharacterized LOC101929373///solute carrier family 9 member B1",TRUE
+"1569681_at",0.888232641270866,0.55400827358122,0.600894475933511,-5.76533140619211,0.377355234911001,"LOC101929378","uncharacterized LOC101929378",TRUE
+"1561607_at",0.637485146909712,0.108322805274969,1.6733358096163,-4.66079427212811,1.09177987121489,"LOC101929384","uncharacterized LOC101929384",TRUE
+"1560826_at",0.936992192746977,0.719048988565355,0.36435249301994,-5.87523055223169,0.148796157848827,"LOC101929398","uncharacterized LOC101929398",TRUE
+"1562869_at",0.938500267760216,0.726461564223023,0.35430293654537,-5.87872643592715,0.108303986457507,"LOC101929406","uncharacterized LOC101929406",TRUE
+"1562653_at",0.777812682097981,0.296793605007289,-1.06851133321688,-5.39838788343532,-0.605394920903712,"LOC101929413","uncharacterized LOC101929413",TRUE
+"1563005_at",0.990009746183328,0.951061214605087,0.0620730499408297,-5.93780696980768,0.0213966401668433,"LOC101929441","uncharacterized LOC101929441",TRUE
+"1569100_a_at",0.874305976196739,0.520295685055359,-0.653283655292709,-5.73392569462784,-0.331419485948705,"LOC101929450","uncharacterized LOC101929450",TRUE
+"1569099_at",0.992512788697266,0.965156286226909,-0.0441804957746987,-5.93873281904963,-0.0289281495179576,"LOC101929450","uncharacterized LOC101929450",TRUE
+"233680_at",0.55937703282623,0.0531180060073525,-2.04307093939829,-4.0885045924993,-1.20864259514376,"LOC101929454","uncharacterized LOC101929454",TRUE
+"243873_at",0.988027606799625,0.942748817217653,-0.0726343249888181,-5.93711418644973,-0.028128479681941,"LOC101929459","uncharacterized LOC101929459",TRUE
+"1563078_at",0.863835356219448,0.489745882139852,0.702396758238937,-5.7022006245205,0.424053119914038,"LOC101929460","uncharacterized LOC101929460",TRUE
+"238290_at",0.770075820151416,0.278762480764858,1.11032863817287,-5.35641976958846,0.597495192401448,"LOC101929464","uncharacterized LOC101929464",TRUE
+"241337_at",0.952293443370532,0.781739337751541,0.280443207139626,-5.90144918269376,0.203989785107676,"LOC101929465","uncharacterized LOC101929465",TRUE
+"1562520_at",0.910358271033989,0.627368802821942,0.492272954763992,-5.82233648503137,0.348938893122582,"LOC101929473","uncharacterized LOC101929473",TRUE
+"244864_at",0.734042693548791,0.218328502774454,1.26695216499024,-5.186717536745,0.532158342808725,"LOC101929475","uncharacterized LOC101929475",TRUE
+"220602_s_at",0.863559206655094,0.488708691754366,0.704094300896587,-5.70106483541429,0.22176416371846,"LOC101929479///LOC727751///LOC642423///GOLGA2P7///GOLGA2P10","golgin subfamily A member 2///golgin A2 pseudogene///golgin A2 pseudogene///golgin A2 pseudogene 7///golgin A2 pseudogene 10",TRUE
+"231334_at",0.944654135079729,0.751139274246729,0.321106065749101,-5.88958724208293,0.212477438205005,"LOC101929480","uncharacterized LOC101929480",TRUE
+"1561678_at",0.425744368467229,0.0180736707440069,2.55304018620226,-3.18303492452699,1.76263177459472,"LOC101929486","uncharacterized LOC101929486",TRUE
+"1561102_at",0.942684843065067,0.743279043242165,0.331638091585155,-5.88625593321721,0.135351556295425,"LOC101929488","uncharacterized LOC101929488",TRUE
+"1554225_a_at",0.778397054392363,0.298317912715822,-1.06506076298614,-5.40178662391455,-0.727514390185727,"LOC101929497","uncharacterized LOC101929497",TRUE
+"1554224_at",0.881970070870254,0.539269826794544,0.623581223028778,-5.75204154258518,0.291949031290588,"LOC101929497","uncharacterized LOC101929497",TRUE
+"202551_s_at",0.740476003158683,0.229339234574555,1.23617326506689,-5.2215969674068,1.2924329634744,"LOC101929500///CRIM1","uncharacterized LOC101929500///cysteine rich transmembrane BMP regulator 1",TRUE
+"202552_s_at",0.783844746433788,0.306664830372487,1.04638527931687,-5.42001043627121,1.13315634345455,"LOC101929500///CRIM1","uncharacterized LOC101929500///cysteine rich transmembrane BMP regulator 1",TRUE
+"1561141_at",0.829803290928719,0.401507001732501,0.855360216910522,-5.58947585094951,0.543599746489524,"LOC101929504","uncharacterized LOC101929504",TRUE
+"1562597_at",0.941397317345279,0.737798160289066,-0.339004630592019,-5.88386266369079,-0.207208958356463,"LOC101929505","uncharacterized LOC101929505",TRUE
+"1568899_at",0.977186090273576,0.89114724548936,0.138434833251836,-5.93035361249766,0.0811626326074002,"LOC101929511","uncharacterized LOC101929511",TRUE
+"237610_at",0.930083070178974,0.691410771295025,0.402172124084134,-5.86121029339735,0.298336232950715,"LOC101929512","uncharacterized LOC101929512",TRUE
+"1562870_at",0.878110025868144,0.529938660900499,-0.638116170144759,-5.74327775482796,-0.480712639851729,"LOC101929517","uncharacterized LOC101929517",TRUE
+"1561197_at",0.913667834629936,0.638080483269995,-0.476932604957962,-5.82949699141171,-0.461304907506913,"LOC101929518///LOC101927088///FLJ43315///LOC442028","uncharacterized LOC101929518///uncharacterized LOC101927088///asparagine synthetase pseudogene///uncharacterized LOC442028",TRUE
+"1560246_at",0.789378278298554,0.31574883053806,1.0264651803656,-5.43912895866381,0.625504369786868,"LOC101929524","uncharacterized LOC101929524",TRUE
+"1561459_at",0.940288390891041,0.733106786043042,-0.345325249572862,-5.88176775302309,-0.225041357132937,"LOC101929526","uncharacterized LOC101929526",TRUE
+"1568844_at",0.782206338814045,0.304241426634101,-1.05176982926953,-5.41478580599576,-0.608255434861832,"LOC101929528","uncharacterized LOC101929528",TRUE
+"241126_at",0.975449397348071,0.882837457309044,-0.149082111020957,-5.92886406526853,-0.0898674950844556,"LOC101929529","uncharacterized LOC101929529",TRUE
+"244182_at",0.544577979658206,0.0466297527674487,2.10734007642187,-3.9811475175391,0.82661162220783,"LOC101929536","uncharacterized LOC101929536",TRUE
+"1564337_at",0.901985640985743,0.600366921751315,0.531491325768797,-5.80302514635618,0.418303358088818,"LOC101929538","uncharacterized LOC101929538",TRUE
+"211050_x_at",0.919485127002411,0.658128610030501,0.448526985079772,-5.84217003798671,0.18190785185968,"LOC101929540///LOC101928670///LOC101928344///LOC100996442///LOC100288069///LOC100134822","uncharacterized LOC101929540///uncharacterized LOC101928670///uncharacterized LOC101928344///uncharacterized LOC100996442///uncharacterized LOC100288069///uncharacterized LOC100134822",TRUE
+"1559538_at",0.948668195792872,0.766442206280529,0.300706084024544,-5.89573692637091,0.116692448704804,"LOC101929549","uncharacterized LOC101929549",TRUE
+"217030_at",0.873665367559788,0.519218989602256,0.654986734830702,-5.73286243065482,0.244936580582492,"LOC101929550","uncharacterized LOC101929550",TRUE
+"1560563_at",0.751737092364469,0.24498310949703,1.19431806231044,-5.26783884278073,0.670985070919596,"LOC101929552","uncharacterized LOC101929552",TRUE
+"237608_at",0.841967750949524,0.434908114101799,-0.795244617842325,-5.63626468610421,-0.517167782263581,"LOC101929570","uncharacterized LOC101929570",TRUE
+"235445_at",0.680160698079016,0.14731494202688,-1.50161394706215,-4.89733241142448,-0.851888960159301,"LOC101929572///POTEH-AS1///LOC100508046","uncharacterized LOC101929572///POTEH antisense RNA 1///uncharacterized LOC100508046",TRUE
+"1556704_s_at",0.729273475042162,0.211598726803383,1.28635529508846,-5.16435261693641,0.616518037496839,"LOC101929583///LOC101928195///LOC100996643///LOC100133920///LOC286297","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene///methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene///monofunctional C1-tetrahydrofolate synthase, mitochondrial-like///methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene///methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene",TRUE
+"1564277_a_at",0.960920874904891,0.822165130828547,0.227442692578821,-5.91451898013993,0.0591828601170619,"LOC101929583///LOC101928195///LOC100996643///LOC100133920///LOC286297","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene///methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene///monofunctional C1-tetrahydrofolate synthase, mitochondrial-like///methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene///methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like pseudogene",TRUE
+"1563300_at",0.774230543658252,0.289746236494444,1.08463149546258,-5.38237969342984,0.669211696421752,"LOC101929584","uncharacterized LOC101929584",TRUE
+"1562455_at",0.877339406737153,0.527224836556794,-0.642369398334028,-5.74067656653224,-0.343298680961976,"LOC101929586","uncharacterized LOC101929586",TRUE
+"240490_at",0.81035488031479,0.354214381063433,0.946275817592962,-5.51271313721286,0.830167082599383,"LOC101929592","uncharacterized LOC101929592",TRUE
+"229191_at",0.749366504723798,0.242401390078557,1.20108381417677,-5.26045761122667,0.803333954612935,"LOC101929597///TBCD","uncharacterized LOC101929597///tubulin folding cofactor D",TRUE
+"229192_s_at",0.754491163266461,0.247706791620201,-1.187237989373,-5.27552411625715,-0.449974595660281,"LOC101929597///TBCD","uncharacterized LOC101929597///tubulin folding cofactor D",TRUE
+"216128_at",0.998347572104896,0.993078445943428,-0.00877340036585649,-5.93964599032554,-0.00661542409481441,"LOC101929597///TBCD","uncharacterized LOC101929597///tubulin folding cofactor D",TRUE
+"1557017_at",0.585036027492332,0.0656594651086773,1.93653183831543,-4.26158634032249,2.07079309310281,"LOC101929607","uncharacterized LOC101929607",TRUE
+"1557018_a_at",0.685154158710982,0.153747796658697,1.47700476031558,-4.92956657624314,1.10595524279411,"LOC101929607","uncharacterized LOC101929607",TRUE
+"240352_at",0.515923821923738,0.0362273086262581,2.22953151007273,-3.77127560971827,1.42479048296571,"LOC101929609","uncharacterized LOC101929609",TRUE
+"238199_x_at",0.9454258600868,0.753176299731152,-0.318382711964475,-5.89043132820831,-0.115731737390727,"LOC101929612///COX3","uncharacterized LOC101929612///cytochrome c oxidase III",TRUE
+"1560610_at",0.902521078772712,0.601635817318172,-0.529629810687771,-5.80397434970657,-0.42882682143464,"LOC101929621","uncharacterized LOC101929621",TRUE
+"1559542_a_at",0.849935057946582,0.452084776705129,0.765443366586866,-5.65827096740069,0.594250477629395,"LOC101929622","uncharacterized LOC101929622",TRUE
+"234288_at",0.862634144901168,0.485711252921764,0.709011839260595,-5.69775987039616,0.536249139655508,"LOC101929628","uncharacterized LOC101929628",TRUE
+"1569738_at",0.94895689004559,0.767809067961821,0.298890402374993,-5.89626489266785,0.143892432352047,"LOC101929631","uncharacterized LOC101929631",TRUE
+"234821_at",0.870980161749509,0.511123686184131,0.667854711082768,-5.72474293840357,0.592184542895434,"LOC101929645","uncharacterized LOC101929645",TRUE
+"1561556_at",0.937409179150458,0.722255127222537,-0.36000115784365,-5.8767560802574,-0.153578617686327,"LOC101929648","uncharacterized LOC101929648",TRUE
+"1561237_at",0.96287357728432,0.831440590491294,-0.215380952760635,-5.91711435527635,-0.150951588317317,"LOC101929657","uncharacterized LOC101929657",TRUE
+"244785_at",0.86481525165637,0.492292773946258,-0.698237075094475,-5.70497272585029,-0.393388091097114,"LOC101929660","uncharacterized LOC101929660",TRUE
+"1561688_at",0.991704861645025,0.961595486787581,0.0486990118498169,-5.93852843088543,0.0245995879218439,"LOC101929662","uncharacterized LOC101929662",TRUE
+"1563031_at",0.840728383233774,0.430013154771513,0.803869238851316,-5.6297483952348,0.650219664371183,"LOC101929680","uncharacterized LOC101929680",TRUE
+"241945_at",0.72844622680189,0.209890723139446,1.29135538194759,-5.1585423901568,0.412456707895702,"LOC101929681","uncharacterized LOC101929681",TRUE
+"234345_at",0.693851377449481,0.163186737313633,1.442366912623,-4.97420582432502,0.523762374841418,"LOC101929683","uncharacterized LOC101929683",TRUE
+"1569786_at",0.89316156038085,0.567345358383739,0.580635743039652,-5.77679678231294,0.161432354430647,"LOC101929694","uncharacterized LOC101929694",TRUE
+"234234_at",0.419667703001518,0.0173480651712686,2.57160373381553,-3.14799681594943,1.85870525481963,"LOC101929705","uncharacterized LOC101929705",TRUE
+"231412_at",0.750020866111355,0.242918069157431,1.19972546905865,-5.26194243333377,0.722080230308816,"LOC101929709","uncharacterized LOC101929709",TRUE
+"1560372_at",0.500677386446044,0.0319202999028653,2.28974759006835,-3.66521711166184,2.37986397064833,"LOC101929713","uncharacterized LOC101929713",TRUE
+"1560373_a_at",0.87825462101175,0.530509024481254,0.637223777673478,-5.74382141562647,0.522426891959161,"LOC101929713","uncharacterized LOC101929713",TRUE
+"244728_at",0.965707350334601,0.839723492259783,0.204637536148942,-5.91930752950267,0.0588734891054825,"LOC101929715","uncharacterized LOC101929715",TRUE
+"1563913_at",0.685081687780732,0.153486892976054,1.47798639845625,-4.92828900334423,0.942595323677281,"LOC101929717","uncharacterized LOC101929717",TRUE
+"234573_at",0.730098225455698,0.21262752215537,1.28335858372609,-5.16782567813105,0.616122304964036,"LOC101929718","uncharacterized LOC101929718",TRUE
+"243251_at",0.937232018318296,0.721476938754127,-0.361056652502913,-5.87638769858969,-0.19380537724925,"LOC101929719","uncharacterized LOC101929719",TRUE
+"222278_at",0.909052380289506,0.622205033290902,0.499710838425679,-5.81878495053555,0.306465615574235,"LOC101929726","uncharacterized LOC101929726",TRUE
+"1556467_at",0.600565040645273,0.0766043089796093,1.85734608617578,-4.38608635389082,0.835411363495884,"LOC101929734","uncharacterized LOC101929734",TRUE
+"228711_at",0.715997485988934,0.191705298534833,1.34665738843532,-5.09301086560577,0.436827128007187,"LOC101929740///ZNF37A","zinc finger protein 761-like///zinc finger protein 37A",TRUE
+"214878_at",0.896118635245982,0.578084648024805,0.564499841612081,-5.78565648103733,0.268969331034273,"LOC101929740///ZNF37A","zinc finger protein 761-like///zinc finger protein 37A",TRUE
+"1560495_at",0.99691938672319,0.984336312055161,-0.019855569872206,-5.9394914610247,-0.00921257063989334,"LOC101929741","uncharacterized LOC101929741",TRUE
+"1560716_at",0.627092759817312,0.0981530876586856,1.72662741837205,-4.58341377640918,1.2388279303224,"LOC101929745","uncharacterized LOC101929745",TRUE
+"1569521_s_at",0.825648186672984,0.393278260115958,0.870654902402533,-5.5770644686321,0.227796122713146,"LOC101929747","uncharacterized LOC101929747",TRUE
+"1569520_at",0.873968636108443,0.519780180987425,-0.65409881902966,-5.73341710427904,-0.231303107713281,"LOC101929747","uncharacterized LOC101929747",TRUE
+"1557638_at",0.964685626382167,0.836635481809787,-0.208639920593886,-5.91850353572771,-0.168844416276684,"LOC101929748","uncharacterized LOC101929748",TRUE
+"1561060_at",0.820536502908875,0.38057973623961,0.894670261842251,-5.55716454552051,0.572625323471057,"LOC101929752","uncharacterized LOC101929752",TRUE
+"1561103_at",0.924448378036419,0.673775526584782,0.426616041899977,-5.85142407336867,0.239531024695131,"LOC101929757","uncharacterized LOC101929757",TRUE
+"1558819_at",0.757950630724418,0.254563237942434,1.16966902661913,-5.29442252108864,0.809081371565558,"LOC101929759","uncharacterized LOC101929759",TRUE
+"244242_at",0.849935057946582,0.452473312360588,0.764777298754295,-5.65875375222499,0.402146473435928,"LOC101929761","uncharacterized LOC101929761",TRUE
+"1564212_at",0.784708646973769,0.308645335963022,1.04200713527571,-5.42424077524725,0.469112577017182,"LOC101929762","uncharacterized LOC101929762",TRUE
+"224490_s_at",0.707818577910656,0.179434599391068,1.3863466851869,-5.04456330183604,1.21359143397467,"LOC101929774","uncharacterized LOC101929774",TRUE
+"1559284_at",0.739189560382301,0.22586620278827,1.24575741815326,-5.21081495731539,0.648681399703109,"LOC101929774","uncharacterized LOC101929774",TRUE
+"224489_at",0.959356077764139,0.815672066311384,0.235906694814846,-5.91261375192743,0.120651475425086,"LOC101929774","uncharacterized LOC101929774",TRUE
+"221455_s_at",0.380084968057051,0.0118431503497724,2.74235907215714,-2.81999303731128,1.82275844379821,"LOC101929777///WNT3","uncharacterized LOC101929777///Wnt family member 3",TRUE
+"229103_at",0.640067422642767,0.110443842482698,1.66275921761422,-4.67593352062489,1.74589766060833,"LOC101929777///WNT3","uncharacterized LOC101929777///Wnt family member 3",TRUE
+"231743_at",0.943464796017993,0.746572591628129,0.327220435008247,-5.88766620497766,0.209963230516282,"LOC101929777///WNT3","uncharacterized LOC101929777///Wnt family member 3",TRUE
+"236704_at",0.68806049531767,0.157495694538649,1.46305054959263,-4.9476533078286,0.841752244604029,"LOC101929787","uncharacterized LOC101929787",TRUE
+"227067_x_at",0.797896456623304,0.331854170438169,0.99211311509187,-5.47131757601691,0.466551565003856,"LOC101929796///LOC100996763///LOC100996717///NOTCH2NL///NOTCH2","notch homolog 2 N-terminal-like protein///notch homolog 2 N-terminal-like protein///notch homolog 2 N-terminal-like protein///notch 2 N-terminal like///notch 2",TRUE
+"1570388_a_at",0.789795896476304,0.31834554923683,1.02084509664525,-5.44446292206657,0.562093301272604,"LOC101929800///LOC101927424///LOC440896","putative uncharacterized protein FLJ45355///uncharacterized LOC101927424///uncharacterized LOC440896",TRUE
+"1556378_a_at",0.949313822701389,0.771108980667892,0.294511147556517,-5.89752525309069,0.219355778529602,"LOC101929800///LOC101927424///LOC440896","putative uncharacterized protein FLJ45355///uncharacterized LOC101927424///uncharacterized LOC440896",TRUE
+"1556883_a_at",0.940227139261806,0.733024265194366,0.345436556376653,-5.88173051860463,0.151826945464605,"LOC101929800///LOC101927424///LOC440896///PGM5","putative uncharacterized protein FLJ45355///uncharacterized LOC101927424///uncharacterized LOC440896///phosphoglucomutase 5",TRUE
+"225899_x_at",0.609499207369658,0.0816999313701174,1.82380704641914,-4.43770858205953,0.987058394857211,"LOC101929819///LOC100133331///LOC100133182///LINC01001///LOC100132062///LOC729737///LINC01000///LINC01002","uncharacterized LOC101929819///uncharacterized LOC100133331///putative uncharacterized protein FLJ44672///long intergenic non-protein coding RNA 1001///uncharacterized LOC100132062///uncharacterized LOC729737///long intergenic non-protein coding RNA 1000///long intergenic non-protein coding RNA 1002",TRUE
+"234664_at",0.826379603754428,0.394597883669065,0.868188319945188,-5.57907989411426,0.759242993828273,"LOC101929819///LOC101060494///LINC01001///LINC01347///LOC388572","uncharacterized LOC101929819///uncharacterized LOC101060494///long intergenic non-protein coding RNA 1001///long intergenic non-protein coding RNA 1347///uncharacterized LOC388572",TRUE
+"207498_s_at",0.707344948707855,0.178844747525147,1.38830806908939,-5.04213878489254,1.05266919986298,"LOC101929829///CYP2D6///CYP2D7","cytochrome P450 family 2 subfamily D member 6 pseudogene///cytochrome P450 family 2 subfamily D member 6///cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)",TRUE
+"1563081_at",0.899825513763341,0.593744948514678,0.541237108145895,-5.7980028110382,0.180422337859706,"LOC101929872","uncharacterized LOC101929872",TRUE
+"217753_s_at",0.868285886165517,0.502400588027974,-0.681848675743455,-5.71574130996076,-0.146819140231232,"LOC101929876///LOC100996747///RPS26P11///RPS26","40S ribosomal protein S26///40S ribosomal protein S26///ribosomal protein S26 pseudogene 11///ribosomal protein S26",TRUE
+"231378_at",0.730048787941067,0.212521929273745,-1.28366564221049,-5.16747012750475,-0.555711732044686,"LOC101929897","uncharacterized LOC101929897",TRUE
+"1562989_at",0.955816406528307,0.798432655341465,-0.258466615579771,-5.90719751264466,-0.102043938228241,"LOC101929902","uncharacterized LOC101929902",TRUE
+"237685_at",0.6708432030569,0.136726526004354,1.54410526145849,-4.84067473231185,0.505808709921554,"LOC101929926","uncharacterized LOC101929926",TRUE
+"1562942_at",0.843475287501313,0.438296395508893,-0.789309717987999,-5.64071036412235,-0.278772028443568,"LOC101929949","uncharacterized LOC101929949",TRUE
+"1569839_s_at",0.958640117088134,0.812541713866058,0.239993514612061,-5.91166903267601,0.175942836774649,"LOC101929953///LRRC37A5P","uncharacterized LOC101929953///leucine rich repeat containing 37 member A5, pseudogene",TRUE
+"1569013_s_at",0.547793752989355,0.0482424052846452,-2.09065078813605,-4.00923239984319,-0.676346599203886,"LOC101929959///BMS1P20","ribosome biogenesis protein BMS1 homolog///BMS1, ribosome biogenesis factor pseudogene 20",TRUE
+"1569376_s_at",0.603702127972549,0.0778747130444504,-1.84880691010543,-4.3992932392621,-1.44156694291286,"LOC101929964","uncharacterized LOC101929964",TRUE
+"1569375_at",0.800907918330069,0.336872051172137,-0.981646883370235,-5.48092688300883,-0.964249601204998,"LOC101929964","uncharacterized LOC101929964",TRUE
+"230685_at",0.595997098747707,0.072609724275418,-1.88502524860748,-4.34298147702553,-1.07043234046432,"LOC101929964///LINC01184","uncharacterized LOC101929964///long intergenic non-protein coding RNA 1184",TRUE
+"235628_x_at",0.691295036264984,0.160934109637976,-1.45048316736906,-4.96382328413759,-0.480147800306294,"LOC101929964///LINC01184","uncharacterized LOC101929964///long intergenic non-protein coding RNA 1184",TRUE
+"228686_at",0.809411730389276,0.352620230460076,-0.949477423113035,-5.50987993974885,-0.452635814967468,"LOC101929964///LINC01184","uncharacterized LOC101929964///long intergenic non-protein coding RNA 1184",TRUE
+"244769_at",0.842224301155785,0.43563890348935,0.793962167426486,-5.637227990117,0.421951609474257,"LOC101929964///LINC01184","uncharacterized LOC101929964///long intergenic non-protein coding RNA 1184",TRUE
+"234493_at",0.999886947266554,0.999740644649671,-0.000328740892827389,-5.93968342811191,-0.000142274719577173,"LOC101929974///LINC01257","uncharacterized LOC101929974///long intergenic non-protein coding RNA 1257",TRUE
+"229446_at",0.9181984176728,0.652593067367888,0.456331767125214,-5.83876391540725,0.176433749002259,"LOC101929977","uncharacterized LOC101929977",TRUE
+"241901_at",0.70939075283402,0.182224955580476,-1.37713694791403,-5.05590967211252,-0.830737354289107,"LOC101929988","uncharacterized LOC101929988",TRUE
+"239275_at",0.896428361916712,0.580914731002125,0.560272872491354,-5.787937361429,0.429502313249508,"LOC101930006///FRMPD2B///FRMPD2","putative protein FRMPD2-like///FERM and PDZ domain containing 2B, pseudogene///FERM and PDZ domain containing 2",TRUE
+"242810_x_at",0.64484773720849,0.115239584204839,1.63946258097305,-4.70902164663056,0.665931170241199,"LOC101930026","uncharacterized LOC101930026",TRUE
+"1558212_at",0.986697480734818,0.937881446251276,0.0788223919528678,-5.93665782540097,0.043702972113719,"LOC101930053///LOC101930048///VLDLR-AS1","uncharacterized LOC101930053///uncharacterized LOC101930048///VLDLR antisense RNA 1",TRUE
+"233997_at",0.721873967309175,0.198044984172613,1.32693068446913,-5.11665225490318,1.00951418194158,"LOC101930064///LOC100287166","collagen alpha-1(I) chain-like///uncharacterized LOC100287166",TRUE
+"235947_at",0.975550833930114,0.883471952603059,-0.148268529718716,-5.92898176964341,-0.123318275234618,"LOC101930067","uncharacterized LOC101930067",TRUE
+"241904_at",0.978999293602992,0.898494843231908,-0.129034076411375,-5.9315772328308,-0.0938671548687671,"LOC101930071///LIPE-AS1","uncharacterized LOC101930071///LIPE antisense RNA 1",TRUE
+"240377_at",0.971352228387114,0.86394099503257,0.173361922620644,-5.92505570482958,0.103106143891377,"LOC101930075///LOC101930013///NPIPA8///NPIPA7///NPIPA5///NPIPA2///NPIPA3///PKD1P1///NPIPA1///PKD1","polycystin-1-like///polycystin-1-like///nuclear pore complex interacting protein family member A8///nuclear pore complex interacting protein family member A7///nuclear pore complex interacting protein family member A5///nuclear pore complex interacting protein family member A2///nuclear pore complex interacting protein family member A3///polycystin 1, transient receptor potential channel interacting pseudogene 1///nuclear pore complex interacting protein family member A1///polycystin 1, transient receptor potential channel interacting",TRUE
+"221501_x_at",0.708473702007515,0.180580792032472,-1.38254994845389,-5.04924847180632,-0.573713308910781,"LOC101930075///NPIPA8///NPIPA7///NPIPA5///NPIPA2///NPIPA3///PKD1P1///NPIPA1","polycystin-1-like///nuclear pore complex interacting protein family member A8///nuclear pore complex interacting protein family member A7///nuclear pore complex interacting protein family member A5///nuclear pore complex interacting protein family member A2///nuclear pore complex interacting protein family member A3///polycystin 1, transient receptor potential channel interacting pseudogene 1///nuclear pore complex interacting protein family member A1",TRUE
+"216949_s_at",0.784552021081681,0.308034762431021,-1.04335475689731,-5.42294034885263,-0.691573829477139,"LOC101930075///PKD1","polycystin-1-like///polycystin 1, transient receptor potential channel interacting",TRUE
+"202327_s_at",0.818598668505758,0.372016787748605,0.911162540321916,-5.54320841628721,0.219132043088972,"LOC101930075///PKD1","polycystin-1-like///polycystin 1, transient receptor potential channel interacting",TRUE
+"202328_s_at",0.974982245454858,0.877793058679097,-0.155554003469034,-5.92790485835156,-0.0456883643724844,"LOC101930075///PKD1","polycystin-1-like///polycystin 1, transient receptor potential channel interacting",TRUE
+"233153_at",0.729210170056086,0.211293126011347,1.28724762732655,-5.16331710985091,0.778338249410068,"LOC101930081","uncharacterized LOC101930081",TRUE
+"242278_at",0.912722788750542,0.633947176625247,-0.482838023050879,-5.82676671877127,-0.145121465958927,"LOC101930097","uncharacterized LOC101930097",TRUE
+"1566145_s_at",0.990810941805126,0.953762715472495,0.058642288210453,-5.93800864939958,0.0513908193721759,"LOC101930100///LOC101928669///LOC644450","uncharacterized LOC101930100///uncharacterized LOC101928669///uncharacterized LOC644450",TRUE
+"231973_s_at",0.988224361618126,0.943958686999862,0.0710966337034401,-5.93722180735012,0.0244662910864335,"LOC101930107///LOC730268///LOC285074///ANAPC1","uncharacterized LOC101930107///anaphase-promoting complex subunit 1-like///anaphase promoting complex subunit 1 pseudogene///anaphase promoting complex subunit 1",TRUE
+"238179_at",0.756952614607938,0.252408356995946,-1.17515227558509,-5.28855078531357,-0.520862814558886,"LOC101930112///SPG7","uncharacterized LOC101930112///SPG7, paraplegin matrix AAA peptidase subunit",TRUE
+"235325_at",0.760325881249847,0.259004472579395,-1.15847586480734,-5.30633402740847,-0.398663726986728,"LOC101930112///SPG7","uncharacterized LOC101930112///SPG7, paraplegin matrix AAA peptidase subunit",TRUE
+"202104_s_at",0.791838559691106,0.322634552812583,-1.01163223163941,-5.4531494669701,-0.316522883330689,"LOC101930112///SPG7","uncharacterized LOC101930112///SPG7, paraplegin matrix AAA peptidase subunit",TRUE
+"230885_at",0.8920930097751,0.563428628349435,0.586559397742238,-5.77348364106675,0.178380570003331,"LOC101930112///SPG7","uncharacterized LOC101930112///SPG7, paraplegin matrix AAA peptidase subunit",TRUE
+"214494_s_at",0.960857829396113,0.822041666888862,-0.227603473045471,-5.9144834340713,-0.0632254654015991,"LOC101930112///SPG7","uncharacterized LOC101930112///SPG7, paraplegin matrix AAA peptidase subunit",TRUE
+"230884_s_at",0.96153827990899,0.825507212783319,-0.223092791689946,-5.91547118945614,-0.0642702857702346,"LOC101930112///SPG7","uncharacterized LOC101930112///SPG7, paraplegin matrix AAA peptidase subunit",TRUE
+"237154_at",0.54295328972902,0.0458420095797354,2.11568184185686,-3.96705640231465,0.97567083230564,"LOC101930114","uncharacterized LOC101930114",TRUE
+"230721_at",0.373927695371586,0.0113323857563917,2.76184486837793,-2.78194558108611,1.01046627017634,"LOC101930115///C16orf52///VWA3A","von Willebrand factor A domain-containing protein 3A///chromosome 16 open reading frame 52///von Willebrand factor A domain containing 3A",TRUE
+"227351_at",0.86679822545543,0.498169193205047,-0.68868624192317,-5.71127813899023,-0.256474649485046,"LOC101930115///C16orf52///VWA3A","von Willebrand factor A domain-containing protein 3A///chromosome 16 open reading frame 52///von Willebrand factor A domain containing 3A",TRUE
+"230296_at",0.929024902913511,0.68715881675589,0.408042355307031,-5.85891193948116,0.173834179161906,"LOC101930115///C16orf52///VWA3A","von Willebrand factor A domain-containing protein 3A///chromosome 16 open reading frame 52///von Willebrand factor A domain containing 3A",TRUE
+"225545_at",0.768852835478002,0.272383248060647,-1.12559239598608,-5.34074471822228,-0.367522881708872,"LOC101930123///EEF2K","eukaryotic elongation factor 2 kinase///eukaryotic elongation factor 2 kinase",TRUE
+"225546_at",0.94895689004559,0.768350191617753,0.298171880090784,-5.89647295004504,0.0899687067917814,"LOC101930123///EEF2K","eukaryotic elongation factor 2 kinase///eukaryotic elongation factor 2 kinase",TRUE
+"233591_at",0.867692227847244,0.500434133731175,0.68502221765541,-5.71367509615552,0.587128172404632,"LOC101930164","uncharacterized LOC101930164",TRUE
+"206955_at",0.712975827977365,0.187255155594406,-1.36081293965517,-5.07586620181712,-0.921885329182949,"LOC101930168///LOC100509620///AQP7","putative aquaporin-7-like protein 3///putative aquaporin-7-like protein 3///aquaporin 7",TRUE
+"1552860_at",0.755685495730197,0.249932525272778,1.18149542903769,-5.28172828251362,0.795556206337185,"LOC101930171///LOC101930165///LOC101929858///LOC101060464///TCEB3CL2///TCEB3CL///TCEB3C","RNA polymerase II transcription factor SIII subunit A3-like///RNA polymerase II transcription factor SIII subunit A3-like///RNA polymerase II transcription factor SIII subunit A3-like///RNA polymerase II transcription factor SIII subunit A3-like///transcription elongation factor B subunit 3C like 2///transcription elongation factor B subunit 3C like///transcription elongation factor B subunit 3C",TRUE
+"220534_at",0.432506261584735,0.0194281733598923,-2.52017887003536,-3.24474279010584,-1.2576588971619,"LOC101930235///TRIM49D2///TRIM49D1///TRIM48","tripartite motif-containing protein 49D1-like///tripartite motif containing 49D2///tripartite motif containing 49D1///tripartite motif containing 48",TRUE
+"205109_s_at",0.468732760220321,0.0247737482858982,2.40845004088525,-3.45138952589491,1.48724838421529,"LOC101930241///ARHGEF4","rho guanine nucleotide exchange factor 4-like///Rho guanine nucleotide exchange factor 4",TRUE
+"211891_s_at",0.562462825747979,0.0550801013655768,2.02501835927968,-4.11826830368504,1.59620052048179,"LOC101930241///ARHGEF4","rho guanine nucleotide exchange factor 4-like///Rho guanine nucleotide exchange factor 4",TRUE
+"1570071_at",0.839888048402106,0.428723100920976,0.806152356925848,-5.62801234155426,0.308786890643583,"LOC101930243///LOC101929865","uncharacterized LOC101930243///uncharacterized LOC101929865",TRUE
+"228078_at",0.94895689004559,0.76924188307409,0.29698821132941,-5.89681461390843,0.215359103909023,"LOC101930243///LOC101929865","uncharacterized LOC101930243///uncharacterized LOC101929865",TRUE
+"1559654_s_at",0.809707978333974,0.353058464584261,-0.948596324207298,-5.51066052551439,-0.355443239647419,"LOC101930262///GRTP1-AS1","uncharacterized LOC101930262///GRTP1 antisense RNA 1",TRUE
+"230452_at",0.709158363400091,0.181915645685023,1.37815230791536,-5.05466183049694,0.423858052194459,"LOC101930279///FLJ42351","serine/arginine repetitive matrix protein 3-like///uncharacterized LOC400999",TRUE
+"1568921_at",0.8920930097751,0.564151114227966,-0.585465123235151,-5.77409812654362,-0.409505543336034,"LOC101930286///LOC101930149","uncharacterized LOC101930286///uncharacterized LOC101930149",TRUE
+"1569751_at",0.688234475234403,0.157619767404834,1.46259322283921,-4.94824371787402,0.974648260043815,"LOC101930296///TBC1D26///ZNF286A","uncharacterized LOC101930296///TBC1 domain family member 26///zinc finger protein 286A",TRUE
+"240576_at",0.84685516668831,0.445383087665704,0.776987093392052,-5.64984071594916,0.255905045730617,"LOC101930296///TBC1D26///ZNF286A","uncharacterized LOC101930296///TBC1 domain family member 26///zinc finger protein 286A",TRUE
+"234826_at",0.819162667476514,0.375533831921332,0.904358696769591,-5.54899451823228,0.411063642367748,"LOC101930299///LOC101929963","uncharacterized LOC101930299///uncharacterized LOC101929963",TRUE
+"1559681_a_at",0.714699002183931,0.190069430297134,1.35183058188187,-5.08676267391911,0.765552276791757,"LOC101930303///LOC101930301///TRIM16L","uncharacterized LOC101930303///uncharacterized LOC101930301///tripartite motif containing 16-like",TRUE
+"230328_at",0.679041081350052,0.146613259539778,1.50435098441682,-4.8937209006341,0.942146482477464,"LOC101930306///RRN3P1///RRN3P2///RRN3","uncharacterized LOC101930306///RRN3 homolog, RNA polymerase I transcription factor pseudogene 1///RRN3 homolog, RNA polymerase I transcription factor pseudogene 2///RRN3 homolog, RNA polymerase I transcription factor",TRUE
+"215559_at",0.774230543658252,0.288512086746254,-1.08748339232189,-5.37952533447361,-1.25324534491128,"LOC101930322///ABCC6","multidrug resistance-associated protein 6-like///ATP binding cassette subfamily C member 6",TRUE
+"208480_s_at",0.98898980125289,0.946725224181011,0.0675811404121329,-5.9374592056999,0.0353471424952461,"LOC101930322///ABCC6","multidrug resistance-associated protein 6-like///ATP binding cassette subfamily C member 6",TRUE
+"214033_at",0.675260084856186,0.141437192350673,-1.52487936023832,-4.86646634651704,-1.11234018987186,"LOC101930322///ABCC6P2///ABCC6P1///ABCC6","multidrug resistance-associated protein 6-like///ATP binding cassette subfamily C member 6 pseudogene 2///ATP binding cassette subfamily C member 6 pseudogene 1///ATP binding cassette subfamily C member 6",TRUE
+"202395_at",0.327864702134751,0.00765894793517549,-2.9331715522982,-2.44253053324649,-1.01187360077113,"LOC101930324///NSF","uncharacterized LOC101930324///N-ethylmaleimide sensitive factor, vesicle fusing ATPase",TRUE
+"217588_at",0.751579819725748,0.244840249451371,-1.19469104455465,-5.26743287508897,-0.602445410086165,"LOC101930343///CATSPER2P1///CATSPER2","uncharacterized LOC101930343///cation channel sperm associated 2 pseudogene 1///cation channel sperm associated 2",TRUE
+"1553323_a_at",0.897024165042344,0.583013483481378,-0.557144860196587,-5.78961453450394,-0.214647139423887,"LOC101930343///CATSPER2P1///CATSPER2","uncharacterized LOC101930343///cation channel sperm associated 2 pseudogene 1///cation channel sperm associated 2",TRUE
+"1561405_s_at",0.990276296955709,0.951498399346525,0.0615177980106923,-5.93784038790464,0.0380670972866,"LOC101930343///STRC///CATSPER2","uncharacterized LOC101930343///stereocilin///cation channel sperm associated 2",TRUE
+"1569847_at",0.559065200216332,0.0528236090410164,2.04583073807521,-4.0839391143105,0.551028700290912,"LOC101930349///LOC101930344///CGNL1","uncharacterized LOC101930349///uncharacterized LOC101930344///cingulin like 1",TRUE
+"225817_at",0.651332373348922,0.120879409182767,-1.61308573460559,-4.74605126566402,-1.48633746191976,"LOC101930349///LOC101930344///CGNL1","uncharacterized LOC101930349///uncharacterized LOC101930344///cingulin like 1",TRUE
+"210123_s_at",0.537586664847644,0.0436298534625727,2.1398170894054,-3.92608769123138,0.757198696565907,"LOC101930361///LOC101929970///CHRFAM7A///CHRNA7","uncharacterized LOC101930361///CHRNA7-FAM7A fusion protein///CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion///cholinergic receptor nicotinic alpha 7 subunit",TRUE
+"214945_at",0.96479405380661,0.837125030638369,0.2080051832625,-5.91863207563257,0.154787335657791,"LOC101930363///LOC101928349///LOC100507387///FAM153C///FAM153A///FAM153B","uncharacterized LOC101930363///uncharacterized LOC101928349///uncharacterized LOC100507387///family with sequence similarity 153, member C///family with sequence similarity 153 member A///family with sequence similarity 153 member B",TRUE
+"1557878_at",0.741260241503758,0.231751771483496,1.22958043794192,-5.22897212557593,0.407366728031439,"LOC101930370","uncharacterized LOC101930370",TRUE
+"1562053_at",0.90344422113846,0.603727736811232,0.52656501650416,-5.80553005382836,0.54937557442567,"LOC101930370","uncharacterized LOC101930370",TRUE
+"240212_at",0.975475861996229,0.883014759871717,-0.14885475454181,-5.92889702263686,-0.122111368011195,"LOC101930370","uncharacterized LOC101930370",TRUE
+"1554907_a_at",0.735677568529031,0.220795519625034,1.25995448211357,-5.19471209378218,0.50929896109729,"LOC101930373///HYDIN2///HYDIN","hydrocephalus-inducing protein homolog///HYDIN2, axonemal central pair apparatus protein (pseudogene)///HYDIN, axonemal central pair apparatus protein",TRUE
+"1563529_at",0.750518254904268,0.243470434195446,1.19827570442251,-5.26352557581006,0.917151233249986,"LOC101930373///HYDIN2///HYDIN","hydrocephalus-inducing protein homolog///HYDIN2, axonemal central pair apparatus protein (pseudogene)///HYDIN, axonemal central pair apparatus protein",TRUE
+"232984_at",0.758920166935337,0.256240092035023,1.16542598036057,-5.29894968612712,0.769830865084693,"LOC101930373///HYDIN2///HYDIN","hydrocephalus-inducing protein homolog///HYDIN2, axonemal central pair apparatus protein (pseudogene)///HYDIN, axonemal central pair apparatus protein",TRUE
+"243354_at",0.796429309934445,0.329045115356364,0.998019970597569,-5.46585345731403,0.871401919668008,"LOC101930373///HYDIN2///HYDIN","hydrocephalus-inducing protein homolog///HYDIN2, axonemal central pair apparatus protein (pseudogene)///HYDIN, axonemal central pair apparatus protein",TRUE
+"220098_at",0.967098323798013,0.84641028442171,0.195982367851342,-5.92099312637842,0.122546331974303,"LOC101930373///HYDIN2///HYDIN","hydrocephalus-inducing protein homolog///HYDIN2, axonemal central pair apparatus protein (pseudogene)///HYDIN, axonemal central pair apparatus protein",TRUE
+"207545_s_at",0.900774308374385,0.596453675111777,-0.537244225276004,-5.80007121246874,-0.205158790515028,"LOC101930388///LOC101928143///NUMB","uncharacterized LOC101930388///uncharacterized LOC101928143///NUMB, endocytic adaptor protein",TRUE
+"209073_s_at",0.931121627074226,0.69495512822385,-0.397289773083024,-5.86309688752296,-0.11852846627947,"LOC101930388///LOC101928143///NUMB","uncharacterized LOC101930388///uncharacterized LOC101928143///NUMB, endocytic adaptor protein",TRUE
+"236930_at",0.957430653957785,0.807623474214616,0.246422982804011,-5.91015012361992,0.175335571969418,"LOC101930388///LOC101928143///NUMB","uncharacterized LOC101930388///uncharacterized LOC101928143///NUMB, endocytic adaptor protein",TRUE
+"209699_x_at",0.667345933561343,0.133871974381359,1.55602293900308,-4.82455879251081,2.52538542703094,"LOC101930400///AKR1C2","aldo-keto reductase family 1 member C2-like///aldo-keto reductase family 1, member C2",TRUE
+"211653_x_at",0.705559553212919,0.177207495696779,1.39377936546329,-5.03536057947018,2.26868311800251,"LOC101930400///AKR1C2","aldo-keto reductase family 1 member C2-like///aldo-keto reductase family 1, member C2",TRUE
+"244266_at",0.82223917891056,0.386944930468564,0.882568210963868,-5.56725546180836,0.643184561613004,"LOC101930400///AKR1C2","aldo-keto reductase family 1 member C2-like///aldo-keto reductase family 1, member C2",TRUE
+"1555854_at",0.908667507590078,0.619967163865527,0.502943132027818,-5.81722534785177,0.712410767967806,"LOC101930400///AKR1C2///AKR1C1","aldo-keto reductase family 1 member C2-like///aldo-keto reductase family 1, member C2///aldo-keto reductase family 1 member C1",TRUE
+"228370_at",0.806341956816164,0.347289217808757,0.96025567035243,-5.50027754836542,1.68750604883773,"LOC101930404///SNORD116-28///SNORD115-26///SNORD115-13///SNORD115-7///SNORD116-22///SNORD116-4///PWARSN///SNORD107///IPW","uncharacterized LOC101930404///small nucleolar RNA, C/D box 116-28///small nucleolar RNA, C/D box 115-26///small nucleolar RNA, C/D box 115-13///small nucleolar RNA, C/D box 115-7///small nucleolar RNA, C/D box 116-22///small nucleolar RNA, C/D box 116-4///Prader Willi/Angelman region RNA, SNRPN neighbor///small nucleolar RNA, C/D box 107///imprinted in Prader-Willi syndrome (non-protein coding)",TRUE
+"1559342_a_at",0.597654932724127,0.0746453404770109,1.87075852015661,-4.36525532158115,1.15069940678726,"LOC101930404///SNORD116-28///SNORD115-26///SNORD115-13///SNORD115-7///SNORD116-22///SNORD116-4///PWARSN///SNORD107///SNRPN///IPW","uncharacterized LOC101930404///small nucleolar RNA, C/D box 116-28///small nucleolar RNA, C/D box 115-26///small nucleolar RNA, C/D box 115-13///small nucleolar RNA, C/D box 115-7///small nucleolar RNA, C/D box 116-22///small nucleolar RNA, C/D box 116-4///Prader Willi/Angelman region RNA, SNRPN neighbor///small nucleolar RNA, C/D box 107///small nuclear ribonucleoprotein polypeptide N///imprinted in Prader-Willi syndrome (non-protein coding)",TRUE
+"241834_at",0.629979353606015,0.101215444045163,-1.71010445193553,-4.60760016365227,-1.45945855229215,"LOC101930404///SNORD116-28///SNORD115-26///SNORD115-13///SNORD115-7///SNORD116-22///SNORD116-4///PWARSN///SNORD107///SNRPN///IPW","uncharacterized LOC101930404///small nucleolar RNA, C/D box 116-28///small nucleolar RNA, C/D box 115-26///small nucleolar RNA, C/D box 115-13///small nucleolar RNA, C/D box 115-7///small nucleolar RNA, C/D box 116-22///small nucleolar RNA, C/D box 116-4///Prader Willi/Angelman region RNA, SNRPN neighbor///small nucleolar RNA, C/D box 107///small nuclear ribonucleoprotein polypeptide N///imprinted in Prader-Willi syndrome (non-protein coding)",TRUE
+"1559343_at",0.812302873476553,0.360047051634574,0.934643922846904,-5.52293264187942,0.377848322973405,"LOC101930404///SNORD116-28///SNORD115-26///SNORD115-13///SNORD115-7///SNORD116-22///SNORD116-4///PWARSN///SNORD107///SNRPN///IPW","uncharacterized LOC101930404///small nucleolar RNA, C/D box 116-28///small nucleolar RNA, C/D box 115-26///small nucleolar RNA, C/D box 115-13///small nucleolar RNA, C/D box 115-7///small nucleolar RNA, C/D box 116-22///small nucleolar RNA, C/D box 116-4///Prader Willi/Angelman region RNA, SNRPN neighbor///small nucleolar RNA, C/D box 107///small nuclear ribonucleoprotein polypeptide N///imprinted in Prader-Willi syndrome (non-protein coding)",TRUE
+"221974_at",0.846928534985425,0.44560755676133,0.776598741493452,-5.6501262605643,1.65348288292297,"LOC101930404///SNORD116-28///SNORD115-26///SNORD115-13///SNORD115-7///SNORD116-22///SNORD116-4///PWARSN///SNORD107///SNRPN///IPW","uncharacterized LOC101930404///small nucleolar RNA, C/D box 116-28///small nucleolar RNA, C/D box 115-26///small nucleolar RNA, C/D box 115-13///small nucleolar RNA, C/D box 115-7///small nucleolar RNA, C/D box 116-22///small nucleolar RNA, C/D box 116-4///Prader Willi/Angelman region RNA, SNRPN neighbor///small nucleolar RNA, C/D box 107///small nuclear ribonucleoprotein polypeptide N///imprinted in Prader-Willi syndrome (non-protein coding)",TRUE
+"1559546_s_at",0.897949253801113,0.586160638888779,-0.552464787582909,-5.79210686965446,-0.396296369230672,"LOC101930404///SNORD116-28///SNORD115-26///SNORD115-13///SNORD115-7///SNORD116-22///SNORD116-4///PWARSN///SNORD107///SNRPN///IPW","uncharacterized LOC101930404///small nucleolar RNA, C/D box 116-28///small nucleolar RNA, C/D box 115-26///small nucleolar RNA, C/D box 115-13///small nucleolar RNA, C/D box 115-7///small nucleolar RNA, C/D box 116-22///small nucleolar RNA, C/D box 116-4///Prader Willi/Angelman region RNA, SNRPN neighbor///small nucleolar RNA, C/D box 107///small nuclear ribonucleoprotein polypeptide N///imprinted in Prader-Willi syndrome (non-protein coding)",TRUE
+"1559545_at",0.937462538530338,0.722851653037007,0.35919234315901,-5.87703764653727,0.373795548379532,"LOC101930404///SNORD116-28///SNORD115-26///SNORD115-13///SNORD115-7///SNORD116-22///SNORD116-4///PWARSN///SNORD107///SNRPN///IPW","uncharacterized LOC101930404///small nucleolar RNA, C/D box 116-28///small nucleolar RNA, C/D box 115-26///small nucleolar RNA, C/D box 115-13///small nucleolar RNA, C/D box 115-7///small nucleolar RNA, C/D box 116-22///small nucleolar RNA, C/D box 116-4///Prader Willi/Angelman region RNA, SNRPN neighbor///small nucleolar RNA, C/D box 107///small nuclear ribonucleoprotein polypeptide N///imprinted in Prader-Willi syndrome (non-protein coding)",TRUE
+"213447_at",0.985709215004606,0.930941219944611,0.0876512744480925,-5.93594219114383,0.0831489978786699,"LOC101930404///SNORD116-28///SNORD115-26///SNORD115-13///SNORD115-7///SNORD116-22///SNORD116-4///PWARSN///SNORD107///SNRPN///IPW","uncharacterized LOC101930404///small nucleolar RNA, C/D box 116-28///small nucleolar RNA, C/D box 115-26///small nucleolar RNA, C/D box 115-13///small nucleolar RNA, C/D box 115-7///small nucleolar RNA, C/D box 116-22///small nucleolar RNA, C/D box 116-4///Prader Willi/Angelman region RNA, SNRPN neighbor///small nucleolar RNA, C/D box 107///small nuclear ribonucleoprotein polypeptide N///imprinted in Prader-Willi syndrome (non-protein coding)",TRUE
+"216850_at",0.968269082055813,0.850903835941837,-0.190174694360033,-5.92208349041119,-0.158156183882528,"LOC101930404///SNORD116-28///SNORD115-26///SNORD115-13///SNORD115-7///SNORD116-22///SNORD116-4///PWARSN///SNORD107///SNURF///SNRPN///IPW","uncharacterized LOC101930404///small nucleolar RNA, C/D box 116-28///small nucleolar RNA, C/D box 115-26///small nucleolar RNA, C/D box 115-13///small nucleolar RNA, C/D box 115-7///small nucleolar RNA, C/D box 116-22///small nucleolar RNA, C/D box 116-4///Prader Willi/Angelman region RNA, SNRPN neighbor///small nucleolar RNA, C/D box 107///SNRPN upstream reading frame///small nuclear ribonucleoprotein polypeptide N///imprinted in Prader-Willi syndrome (non-protein coding)",TRUE
+"217239_x_at",0.900250794823241,0.595085557810598,-0.539259832721374,-5.79902894462481,-0.49042389697798,"LOC101930405","uncharacterized LOC101930405",TRUE
+"217369_at",0.837609393049242,0.421611954648992,-0.818815031924865,-5.6182999488792,-0.414055924045694,"LOC101930405///IGHG1","uncharacterized LOC101930405///immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"239742_at",0.989638901366417,0.949986229417665,0.0634384336929591,-5.93772351698932,0.052369815636375,"LOC101930415","uncharacterized LOC101930415",TRUE
+"211751_at",0.729083413548563,0.210954884582801,1.28823643135275,-5.1621689385907,1.12553270929367,"LOC101930416///LOC101929792///LOC100996724///LOC653513///PDE4DIP","myomegalin-like///uncharacterized LOC101929792///phosphodiesterase 4D interacting protein-like///phosphodiesterase 4D interacting protein-like///phosphodiesterase 4D interacting protein",TRUE
+"212390_at",0.827768017240356,0.396689309639289,-0.864290015633725,-5.58225432762198,-0.686257165541528,"LOC101930416///LOC101929792///LOC100996724///PDE4DIP","myomegalin-like///uncharacterized LOC101929792///phosphodiesterase 4D interacting protein-like///phosphodiesterase 4D interacting protein",TRUE
+"214099_s_at",0.929088231432081,0.687918389313333,-0.406992627818505,-5.85932534281487,-0.368313976327213,"LOC101930416///LOC101929792///LOC100996724///PDE4DIP","myomegalin-like///uncharacterized LOC101929792///phosphodiesterase 4D interacting protein-like///phosphodiesterase 4D interacting protein",TRUE
+"213388_at",0.937113154905832,0.719644801224614,-0.363543322959292,-5.87551560768404,-0.161502600777609,"LOC101930416///LOC101929792///LOC100996724///PDE4DIP","myomegalin-like///uncharacterized LOC101929792///phosphodiesterase 4D interacting protein-like///phosphodiesterase 4D interacting protein",TRUE
+"214129_at",0.942502815705589,0.742126123914376,-0.333186096617019,-5.88575732799485,-0.141396254688862,"LOC101930416///LOC101929792///LOC100996724///PDE4DIP","myomegalin-like///uncharacterized LOC101929792///phosphodiesterase 4D interacting protein-like///phosphodiesterase 4D interacting protein",TRUE
+"214130_s_at",0.973524792694617,0.872691305707335,-0.162106407746997,-5.9268922977492,-0.0863894094738011,"LOC101930416///LOC101929792///LOC100996724///PDE4DIP","myomegalin-like///uncharacterized LOC101929792///phosphodiesterase 4D interacting protein-like///phosphodiesterase 4D interacting protein",TRUE
+"212392_s_at",0.992556028381381,0.965234641591916,0.0440810768146568,-5.93873709256596,0.0190201300967558,"LOC101930416///LOC101929792///LOC100996724///PDE4DIP","myomegalin-like///uncharacterized LOC101929792///phosphodiesterase 4D interacting protein-like///phosphodiesterase 4D interacting protein",TRUE
+"240305_at",0.8920930097751,0.563268495378864,-0.586802032408286,-5.77334724019866,-0.287648931863587,"LOC101930421","uncharacterized LOC101930421",TRUE
+"1559526_at",0.915353407558177,0.642919414394648,0.470040811357505,-5.83264172871136,0.332728515802078,"LOC101930421","uncharacterized LOC101930421",TRUE
+"1569784_at",0.877823543873753,0.528668928261087,0.640104673258275,-5.74206369393935,0.655652534050378,"LOC101930449///LOC101930028","uncharacterized LOC101930449///uncharacterized LOC101930028",TRUE
+"1561087_at",0.838245037296515,0.422890891792428,0.816527866054207,-5.62006473141508,0.740760346429555,"LOC101930452","uncharacterized LOC101930452",TRUE
+"240891_at",0.831875452294783,0.407185580291662,-0.844922526005161,-5.5978282005992,-0.662306288487345,"LOC101930453///FSTL1","uncharacterized LOC101930453///follistatin like 1",TRUE
+"215847_at",0.986342822130003,0.933916615326705,0.0838653471395507,-5.93625835319536,0.101940656560618,"LOC101930458///HERC2P3","uncharacterized LOC101930458///hect domain and RLD 2 pseudogene 3",TRUE
+"234429_at",0.8920930097751,0.562730305532815,0.587617762378142,-5.77288826476809,0.466065616516625,"LOC101930476///LINC00476","uncharacterized LOC101930476///long intergenic non-protein coding RNA 476",TRUE
+"1557788_a_at",0.941161916043887,0.736309504290973,-0.3410087376001,-5.88320256388536,-0.30640867194872,"LOC101930476///LINC00476","uncharacterized LOC101930476///long intergenic non-protein coding RNA 476",TRUE
+"227893_at",0.966051687342135,0.841511856902718,0.202321195531298,-5.91976574744585,0.0748108239913616,"LOC101930476///LINC00476","uncharacterized LOC101930476///long intergenic non-protein coding RNA 476",TRUE
+"1552258_at",0.943988850936011,0.749717363603417,0.323008524159077,-5.88899336418762,0.21009762006434,"LOC101930489///LINC00152","uncharacterized LOC101930489///long intergenic non-protein coding RNA 152",TRUE
+"225799_at",0.906507435035949,0.614528554750646,0.510821227983925,-5.81338302258335,0.472257839386891,"LOC101930489///MIR4435-2HG///LINC00152","uncharacterized LOC101930489///MIR4435-2 host gene///long intergenic non-protein coding RNA 152",TRUE
+"204145_at",0.984397001287044,0.923874360737415,-0.0966485961162341,-5.93513487174031,-0.0373754626795915,"LOC101930531///LOC101930278///FRG1CP///FRG1","uncharacterized LOC101930531///uncharacterized LOC101930278///FSHD region gene 1 family member C, pseudogene///FSHD region gene 1",TRUE
+"242135_at",0.697152783882664,0.166721846238991,1.4298099420006,-4.99017531529992,1.87183564636311,"LOC101930531///LOC101930288","uncharacterized LOC101930531///uncharacterized LOC101930288",TRUE
+"1561211_at",0.981372324306002,0.911801238270153,0.112039100624194,-5.93357134301037,0.0845339009119908,"LOC101930541","uncharacterized LOC101930541",TRUE
+"234683_at",0.739189560382301,0.226268551455152,1.24464137292269,-5.2120741744145,0.903351043398488,"LOC101930568///KRTAP4-6","keratin-associated protein 4-8-like///keratin associated protein 4-6",TRUE
+"219477_s_at",0.793816937298172,0.325642240490033,1.00522248922208,-5.45915096041103,0.606203793882441,"LOC101930578///MRPS31P5///THSD1","uncharacterized LOC101930578///mitochondrial ribosomal protein S31 pseudogene 5///thrombospondin type 1 domain containing 1",TRUE
+"1556876_s_at",0.975398143273847,0.881989578398082,0.150169464322694,-5.92870574957846,0.0875692745734469,"LOC101930578///TPTE2P2","uncharacterized LOC101930578///transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 2",TRUE
+"210424_s_at",0.734730148360473,0.219384491221414,1.26394947112994,-5.19015262901717,1.2585487110885,"LOC101930583///GOLGA8B///GOLGA8A","uncharacterized LOC101930583///golgin A8 family member B///golgin A8 family member A",TRUE
+"210425_x_at",0.801917957653237,0.339674293219905,0.975848598640721,-5.48621047777814,0.634479440745391,"LOC101930583///GOLGA8B///GOLGA8A","uncharacterized LOC101930583///golgin A8 family member B///golgin A8 family member A",TRUE
+"213650_at",0.830326542770255,0.402725072173172,0.853113384589309,-5.5912818635592,0.368678840035106,"LOC101930583///GOLGA8B///GOLGA8A","uncharacterized LOC101930583///golgin A8 family member B///golgin A8 family member A",TRUE
+"212370_x_at",0.871744769522775,0.513732166241771,-0.663696090356895,-5.72738352163802,-0.21334552716122,"LOC101930591///FAM21A///FAM21C","uncharacterized LOC101930591///family with sequence similarity 21 member A///family with sequence similarity 21 member C",TRUE
+"212929_s_at",0.932415412515157,0.701997500751268,-0.38761785718874,-5.86676719363998,-0.11611324734522,"LOC101930591///FAM21A///FAM21C","uncharacterized LOC101930591///family with sequence similarity 21 member A///family with sequence similarity 21 member C",TRUE
+"214946_x_at",0.996261754016157,0.981907423972987,0.0229349980527693,-5.9394272819052,0.00901651464393716,"LOC101930591///FAM21A///FAM21C","uncharacterized LOC101930591///family with sequence similarity 21 member A///family with sequence similarity 21 member C",TRUE
+"211068_x_at",0.995111934465262,0.977515840015057,-0.0285033977979286,-5.93928777713162,-0.00965368631731245,"LOC101930591///FAM21C","uncharacterized LOC101930591///family with sequence similarity 21 member C",TRUE
+"239779_at",0.961212424803935,0.823791349920096,-0.225325525018131,-5.91498472146119,-0.153818967952412,"LOC101930595///PGGHG","uncharacterized LOC101930595///protein-glucosylgalactosylhydroxylysine glucosidase",TRUE
+"208409_at",0.830592576740524,0.403065153532454,0.852486854107862,-5.59178468190798,0.554746268956171,"LOC101930602///SLC14A2","putative uncharacterized protein encoded by LINC00596-like///solute carrier family 14 member 2",TRUE
+"241888_at",0.483342512055348,0.0276784831005191,-2.35681916706792,-3.54514887461639,-2.21907038556095,"LOC101930608","uncharacterized LOC101930608",TRUE
+"240048_at",0.959357995170594,0.81624387197954,-0.235160621656445,-5.91278447402849,-0.10868987411659,"LOC101930630///STRC","putative stereocilin-like protein-like///stereocilin",TRUE
+"1561306_s_at",0.982483061874645,0.915420843549703,-0.107422184191832,-5.93406456575351,-0.0731783455069861,"LOC101930630///STRC","putative stereocilin-like protein-like///stereocilin",TRUE
+"224752_at",0.767011398042819,0.268264557220695,1.13558663621231,-5.33037869546783,0.397927582245966,"LOC101930655///C7orf73","uncharacterized LOC101930655///chromosome 7 open reading frame 73",TRUE
+"224751_at",0.855075448726859,0.467334267619171,0.739554445162094,-5.67674317032984,0.35791417724112,"LOC101930655///C7orf73","uncharacterized LOC101930655///chromosome 7 open reading frame 73",TRUE
+"1558578_a_at",0.697412165374288,0.167827031105761,1.42592816984578,-4.99508888945092,0.52178069675381,"LOC101930655///C7orf73///SLC13A4","uncharacterized LOC101930655///chromosome 7 open reading frame 73///solute carrier family 13 member 4",TRUE
+"238273_at",0.980009054680439,0.906039639574128,0.119393386222323,-5.93274288677059,0.0645269953789995,"LOC101930655///C7orf73///SLC13A4","uncharacterized LOC101930655///chromosome 7 open reading frame 73///solute carrier family 13 member 4",TRUE
+"1562546_at",0.887083096014278,0.551500358380805,0.60473218192664,-5.76311667412368,0.267957890826258,"LOC101930657","uncharacterized LOC101930657",TRUE
+"240894_at",0.84030126411548,0.429425836683139,0.804908137340336,-5.62895900352753,0.545505813051567,"LOC102467079","uncharacterized LOC102467079",TRUE
+"1561473_at",0.96635324070119,0.843311778237457,0.199991029213893,-5.92022145800431,0.0717257258725807,"LOC102546226","uncharacterized LOC102546226",TRUE
+"1557873_at",0.820611742812032,0.381082044893562,0.893710433268934,-5.55796951448801,0.579950677477543,"LOC102546294","uncharacterized LOC102546294",TRUE
+"1560491_at",0.667600335207197,0.133996270298377,1.55549965713929,-4.8252684640749,1.04739365631506,"LOC102546299","uncharacterized LOC102546299",TRUE
+"240610_at",0.83766047465051,0.422239097967408,0.817692948409837,-5.61916632931507,0.787142313726524,"LOC102546299","uncharacterized LOC102546299",TRUE
+"231503_at",0.893600768892136,0.568671588857683,0.578634709165877,-5.77790861957707,0.540154686484867,"LOC102546299","uncharacterized LOC102546299",TRUE
+"228661_s_at",0.735413789306046,0.220482905062729,-1.26083788389932,-5.1937049352563,-0.676422405840627,"LOC102606465","uncharacterized LOC102606465",TRUE
+"232589_at",0.954506242294505,0.791512207616926,-0.267560911301406,-5.9048752226459,-0.109638199339883,"LOC102606465","uncharacterized LOC102606465",TRUE
+"235808_at",0.993474831312851,0.969509207515007,-0.0386580783979903,-5.93895561691655,-0.0131247755250588,"LOC102606465","uncharacterized LOC102606465",TRUE
+"1561035_at",0.108265848398903,0.00051088411315806,4.063279966812,-0.064140593933435,2.1293420370847,"LOC102723335","uncharacterized LOC102723335",TRUE
+"244449_at",0.925279049529098,0.676439485847784,0.422906955789032,-5.85294554870721,0.196103447695407,"LOC102723380","uncharacterized LOC102723380",TRUE
+"217217_at",0.809744885587232,0.353153705000986,0.94840493482393,-5.51082999396794,0.322616749626432,"LOC102723407///IGHV4-31///IGHM///IGHG4///IGHG1///IGHA2///IGHA1","putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 4 (G4m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"211636_at",0.823074246722209,0.389645391199605,0.877473128825422,-5.57146571962243,0.470066595661928,"LOC102723407///IGHV4-31///IGHM///IGHG4///IGHG1///IGHA2///IGHA1","putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 4 (G4m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1",TRUE
+"1560135_at",0.948877708198809,0.767311021720968,-0.299551866986856,-5.8960729181808,-0.0968929896285564,"LOC102723409","uncharacterized LOC102723409",TRUE
+"1563188_at",0.576675680499645,0.0613644098609407,1.97081527301629,-4.20657296445626,2.28044219890135,"LOC102723448","uncharacterized LOC102723448",TRUE
+"217260_x_at",0.985361089461736,0.927449379651565,-0.0920960111255825,-5.93555321364391,-0.0632744749880101,"LOC102723479","uncharacterized LOC102723479",TRUE
+"237017_s_at",0.73720080312946,0.223409047375665,1.25260627170767,-5.20306626973514,0.912413908528072,"LOC102723493","uncharacterized LOC102723493",TRUE
+"244269_at",0.995111934465262,0.97750072647495,-0.0285225628152543,-5.93928724483946,-0.0156432510504159,"LOC102723526","uncharacterized LOC102723526",TRUE
+"1560735_s_at",0.895213601869362,0.57335076363673,0.571593650181661,-5.78179129959027,0.623425742919344,"LOC102723532///LOC101927079///LOC727924///OR4N4","olfactory receptor 4N4///uncharacterized LOC101927079///uncharacterized LOC727924///olfactory receptor family 4 subfamily N member 4",TRUE
+"237680_at",0.85334340854827,0.461508164252136,0.749384871244152,-5.66979985641732,0.632171458984435,"LOC102723542","uncharacterized LOC102723542",TRUE
+"221639_x_at",0.893462835798285,0.568293549253146,0.579204856882071,-5.77759220613902,0.412974336217093,"LOC102723559","uncharacterized LOC102723559",TRUE
+"228609_at",0.840846485760608,0.430150456455861,0.803626494935977,-5.62993270259451,0.342728216750346,"LOC102723600///MIR1302-11///MIR1302-10///MIR1302-9///MIR1302-2","uncharacterized LOC102723600///microRNA 1302-11///microRNA 1302-10///microRNA 1302-9///microRNA 1302-2",TRUE
+"216499_at",0.906476756086155,0.613311799075704,0.512588233583463,-5.81251321780349,0.192968979395439,"LOC102723620","uncharacterized LOC102723620",TRUE
+"240591_at",0.71278153948281,0.186796018637397,1.36228845773648,-5.07407049438765,1.0619096468877,"LOC102723645","uncharacterized LOC102723645",TRUE
+"1561110_at",0.888335675282745,0.554404950790326,-0.600288299755507,-5.76567998406079,-0.746105398097735,"LOC102723648","uncharacterized LOC102723648",TRUE
+"241095_at",0.740616728918811,0.23072564688933,1.23237816394018,-5.22584656439671,0.436073313129081,"LOC102723661","uncharacterized LOC102723661",TRUE
+"240970_x_at",0.803203434524165,0.341216390922593,0.972671733043694,-5.48909324401713,0.708959099841047,"LOC102723684","uncharacterized LOC102723684",TRUE
+"236190_at",0.94632739401154,0.757292751106731,0.312886783671378,-5.89211307241391,0.188835153753357,"LOC102723692","uncharacterized LOC102723692",TRUE
+"1558821_s_at",0.58278048219982,0.0644336170991845,1.94610986516781,-4.24628329605761,1.42309482344194,"LOC102723694","uncharacterized LOC102723694",TRUE
+"229455_at",0.971084206066165,0.86139014217797,0.17664733550659,-5.92449644450693,0.134638534990947,"LOC102723694","uncharacterized LOC102723694",TRUE
+"1566080_at",0.654592482818544,0.123475926597408,1.60128700135953,-4.7624647248402,1.28781758993155,"LOC102723697","uncharacterized LOC102723697",TRUE
+"1561386_at",0.94079969729523,0.735058464459006,0.342694054770767,-5.88264448697778,0.185880960943343,"LOC102723701","uncharacterized LOC102723701",TRUE
+"1562878_at",0.787313843676753,0.313205198508288,1.03200190793973,-5.43384826239561,0.534091461113614,"LOC102723704","uncharacterized LOC102723704",TRUE
+"243674_at",0.88113080359582,0.537407565911428,0.62647114067812,-5.75031455812093,0.562607294747196,"LOC102723709///LOC102723678","uncharacterized LOC102723709///uncharacterized LOC102723678",TRUE
+"241803_s_at",0.844169896707408,0.44069018834466,0.785133743725206,-5.64381968316859,0.512936514492145,"LOC102723709///LOC102723678///LOC101928102","uncharacterized LOC102723709///uncharacterized LOC102723678///putative uncharacterized protein LOC401522-like",TRUE
+"235921_at",0.465776708318531,0.0240610783963032,2.42197084615267,-3.42665085003643,2.36341558183545,"LOC102723721","uncharacterized LOC102723721",TRUE
+"228117_at",0.905462783815257,0.611360370416193,0.515425609723928,-5.81111039956952,0.267580519453372,"LOC102723722///NDUFA6-AS1","uncharacterized LOC102723722///NDUFA6 antisense RNA 1 (head to head)",TRUE
+"1559925_s_at",0.771534633613556,0.280860257096492,1.10536482910148,-5.36147643827064,0.886963639803128,"LOC102723757","uncharacterized LOC102723757",TRUE
+"1559924_at",0.942049201741017,0.739476317152647,-0.336747103326968,-5.88460162466666,-0.146196930504214,"LOC102723757","uncharacterized LOC102723757",TRUE
+"244766_at",0.912722788750542,0.634307782494016,0.482322120280774,-5.82700654769857,0.177737056550789,"LOC102723773///LOC101060604///LOC101060596///LOC101060386///SMG1P7///NPIPA5///SMG1P3///NPIPB5///SMG1P1///LOC613037///SMG1P5///BOLA2///SMG1P2///NPIPB4///SLC7A5P1///SMG1","serine/threonine-protein kinase SMG1-like///putative L-type amino acid transporter 1-like protein IMAA///serine/threonine-protein kinase SMG1-like///putative uncharacterized SMG1-like protein///SMG1P7, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 7///nuclear pore complex interacting protein family member A5///SMG1P3, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 3///nuclear pore complex interacting protein family member B5///SMG1P1, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 1///nuclear pore complex interacting protein member///SMG1P5, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 5///bolA family member 2///SMG1P2, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 2///nuclear pore complex interacting protein family member B4///solute carrier family 7 member 5 pseudogene 1///SMG1, nonsense mediated mRNA decay associated PI3K related kinase",TRUE
+"235543_at",0.913627134030439,0.637894237435346,0.477198330294029,-5.82937484380169,0.224236183139863,"LOC102723779","uncharacterized LOC102723779",TRUE
+"244270_at",0.937531773202399,0.723131939449486,-0.358812394033755,-5.87716969930688,-0.150593146295624,"LOC102723809","uncharacterized LOC102723809",TRUE
+"1569849_at",0.966593471043185,0.844119376530079,0.19894588662835,-5.92042414825628,0.0651099095869139,"LOC102723831","uncharacterized LOC102723831",TRUE
+"235898_at",0.842038788192302,0.435144496913209,0.794829648151929,-5.63657654785491,0.474753932531717,"LOC102723845","uncharacterized LOC102723845",TRUE
+"242822_at",0.93613089056626,0.714427774322551,0.370637011990229,-5.87299533723049,0.27886666326266,"LOC102723847","uncharacterized LOC102723847",TRUE
+"239360_at",0.597654932724127,0.0747681562034388,1.86990867290036,-4.3665783755237,0.901134486578828,"LOC102723886","uncharacterized LOC102723886",TRUE
+"225035_x_at",0.959931948475729,0.818738117115111,0.231907802273691,-5.91352252328921,0.0724631586587225,"LOC102723897///MIR6859-1///MIR6859-2///LOC101930154///LOC100288778///WASH1///WASH7P///WASH2P///WASH3P","WAS protein family homolog 2-like///microRNA 6859-1///microRNA 6859-2///WAS protein family homolog 6-like///WAS protein family homolog 1 pseudogene///WAS protein family homolog 1///WAS protein family homolog 7 pseudogene///WAS protein family homolog 2 pseudogene///WAS protein family homolog 3 pseudogene",TRUE
+"243761_at",0.648831254679075,0.119655519724355,1.61872076786075,-4.73817934450607,1.47065986974553,"LOC102723899///CLDN12","pituitary tumor-transforming gene 1 protein-interacting protein///claudin 12",TRUE
+"1564149_at",0.907111393934291,0.615727185466027,0.509082153378196,-5.81423621848747,0.269273816680121,"LOC102723927","uncharacterized LOC102723927",TRUE
+"237178_at",0.825648186672984,0.393183904378051,0.870831473069844,-5.57691999030474,0.520469323986243,"LOC102723932","uncharacterized LOC102723932",TRUE
+"235704_at",0.954577684533304,0.792135575006873,0.266740798231486,-5.90508791596856,0.090306096728419,"LOC102723983///DAZAP2","uncharacterized LOC102723983///DAZ associated protein 2",TRUE
+"238842_at",0.98416963712855,0.92287841418529,0.0979172464557552,-5.93501470183449,0.0316779603477944,"LOC102724002","uncharacterized LOC102724002",TRUE
+"244577_at",0.993225426079816,0.968468432767228,-0.0399783586309401,-5.93890505275196,-0.0222101962967294,"LOC102724009","uncharacterized LOC102724009",TRUE
+"235466_s_at",0.830592576740524,0.403193972629091,0.852249619632204,-5.59197498317357,0.325060226391932,"LOC102724017","uncharacterized LOC102724017",TRUE
+"240346_at",0.564004192185035,0.0559356975874365,2.01732514834149,-4.13089910313394,0.978912968994027,"LOC102724030","uncharacterized LOC102724030",TRUE
+"213212_x_at",0.842348838616739,0.436110993593489,0.793134409254515,-5.63784897835665,0.333570983946009,"LOC102724093///GOLGA6L4///GOLGA6L9///GOLGA6L5P","golgin subfamily A member 6-like protein 4///golgin A6 family-like 4///golgin A6 family-like 9///golgin A6 family-like 5, pseudogene",TRUE
+"238180_at",0.878774484192636,0.531899644115901,0.635050189276314,-5.74514254171948,0.385634860195927,"LOC102724094","uncharacterized LOC102724094",TRUE
+"242304_at",0.62952950109137,0.100387114890832,-1.71453121823704,-4.60113728943406,-0.483483333641029,"LOC102724112///PYM1","uncharacterized LOC102724112///PYM homolog 1, exon junction complex associated factor",TRUE
+"230991_at",0.67368843181164,0.140291078979003,-1.52950800734662,-4.86028045371993,-1.19568332333321,"LOC102724156","uncharacterized LOC102724156",TRUE
+"1560520_at",0.729609472869019,0.211897006304292,1.285485300039,-5.16536161452888,0.425751625911957,"LOC102724162","uncharacterized LOC102724162",TRUE
+"239807_at",0.760227035076299,0.258021179467148,-1.16094169908687,-5.3037185675391,-0.556775781771226,"LOC102724165","uncharacterized LOC102724165",TRUE
+"244179_x_at",0.622917527985155,0.093894592982561,-1.75035153432579,-4.54838419098737,-0.735723003814995,"LOC102724197///LOC100132705///GGT2///GGT8P///GGTLC1///GGTLC2///GGT3P///GGT1","inactive gamma-glutamyltranspeptidase 2-like///immunoglobulin superfamily member 3-like///gamma-glutamyltransferase 2///gamma-glutamyltransferase 8 pseudogene///gamma-glutamyltransferase light chain 1///gamma-glutamyltransferase light chain 2///gamma-glutamyltransferase 3 pseudogene///gamma-glutamyltransferase 1",TRUE
+"215603_x_at",0.724970327905974,0.202988460586734,-1.31188835837116,-5.13448215121124,-0.790254008203167,"LOC102724197///LOC100132705///GGT2///GGTLC1///GGTLC2///GGT3P///GGT1","inactive gamma-glutamyltranspeptidase 2-like///immunoglobulin superfamily member 3-like///gamma-glutamyltransferase 2///gamma-glutamyltransferase light chain 1///gamma-glutamyltransferase light chain 2///gamma-glutamyltransferase 3 pseudogene///gamma-glutamyltransferase 1",TRUE
+"208184_s_at",0.837839105061376,0.422551587655745,0.817134232234901,-5.61959730861068,0.240176849873867,"LOC102724200///TRAPPC10","trafficking protein particle complex subunit 10-like///trafficking protein particle complex 10",TRUE
+"209412_at",0.989503046394351,0.948239819219607,0.0656568871822939,-5.93758405403737,0.0163709524017932,"LOC102724200///TRAPPC10","trafficking protein particle complex subunit 10-like///trafficking protein particle complex 10",TRUE
+"212706_at",0.695744345349551,0.165273441811032,1.43492863498927,-4.98367932876466,1.11781020089657,"LOC102724229///RASA4B///RASA4","uncharacterized LOC102724229///RAS p21 protein activator 4B///RAS p21 protein activator 4",TRUE
+"1565152_at",0.74371414757151,0.23446608499385,1.22222489978919,-5.23716031215599,0.770082014308357,"LOC102724250","neuroblastoma breakpoint family member 1",TRUE
+"230712_at",0.936992192746977,0.718804828827633,-0.364684156659495,-5.87511353255311,-0.154675714599016,"LOC102724250///LOC101930059///NBPF15///NBPF11///NBPF1","neuroblastoma breakpoint family member 1///uncharacterized LOC101930059///neuroblastoma breakpoint family member 15///neuroblastoma breakpoint family member 11///neuroblastoma breakpoint family member 1",TRUE
+"1569519_at",0.988404376556799,0.944674149087372,0.0701873957417477,-5.93728436082428,0.0282374639807914,"LOC102724250///NBPF26///NBPF10///NBPF8///NBPF9///NBPF15///NBPF11///NBPF12///NBPF1///NBPF14","neuroblastoma breakpoint family member 1///neuroblastoma breakpoint family member 26///neuroblastoma breakpoint family member 10///neuroblastoma breakpoint family member 8///neuroblastoma breakpoint family member 9///neuroblastoma breakpoint family member 15///neuroblastoma breakpoint family member 11///neuroblastoma breakpoint family member 12///neuroblastoma breakpoint family member 1///neuroblastoma breakpoint family member 14",TRUE
+"215434_x_at",0.969859842767097,0.855783616002679,0.183875406142996,-5.92322920029183,0.0577776442599998,"LOC102724250///NBPF26///NBPF19///NBPF10///NBPF15///NBPF11///NBPF1///NBPF14","neuroblastoma breakpoint family member 1///neuroblastoma breakpoint family member 26///neuroblastoma breakpoint family member 19///neuroblastoma breakpoint family member 10///neuroblastoma breakpoint family member 15///neuroblastoma breakpoint family member 11///neuroblastoma breakpoint family member 1///neuroblastoma breakpoint family member 14",TRUE
+"241804_at",0.837015771520825,0.419134676827058,-0.823257638410214,-5.6148588066398,-0.640443879647214,"LOC102724275","uncharacterized LOC102724275",TRUE
+"243021_at",0.868397087637799,0.503578896395712,0.67995043957805,-5.71697281975325,0.627990247767442,"LOC102724312","uncharacterized LOC102724312",TRUE
+"238639_x_at",0.897011777275924,0.582298980049437,-0.558209134639609,-5.78904491601868,-0.221285005738108,"LOC102724312","uncharacterized LOC102724312",TRUE
+"239590_x_at",0.834881450121645,0.413520440697124,-0.833387425227628,-5.60694733515938,-0.377484661269821,"LOC102724314///FAM95B1","uncharacterized LOC102724314///family with sequence similarity 95 member B1",TRUE
+"236788_at",0.474859593446097,0.0261335622620815,2.38362069190627,-3.4966199506968,0.885825360301857,"LOC102724323","uncharacterized LOC102724323",TRUE
+"1560208_at",0.737123149977386,0.222766350998242,1.25440715639442,-5.20102272158733,0.557081798342243,"LOC102724352///LOC101930593","uncharacterized LOC102724352///uncharacterized LOC101930593",TRUE
+"238742_x_at",0.887706911509597,0.552578272086285,-0.603081598963667,-5.7640708904603,-0.68376115308542,"LOC102724362","uncharacterized LOC102724362",TRUE
+"209207_s_at",0.730101539866086,0.212938052268092,-1.2824562600828,-5.1688700818186,-0.474168540371794,"LOC102724364///LOC100996517///SEC22B","vesicle-trafficking protein SEC22b-like///vesicle-trafficking protein SEC22b///SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)",TRUE
+"209206_at",0.768014035136808,0.271175325986577,-1.1285119483167,-5.3377249282443,-0.470963975564011,"LOC102724364///SEC22B","vesicle-trafficking protein SEC22b-like///SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)",TRUE
+"1568887_at",0.620025427399625,0.0897917024993184,1.77409747584686,-4.51296952628793,0.739493540591086,"LOC102724382","uncharacterized LOC102724382",TRUE
+"239210_at",0.308621629697291,0.00635479331003176,-3.01375202092448,-2.2801086859138,-1.31822829119473,"LOC102724387","uncharacterized LOC102724387",TRUE
+"244192_x_at",0.923935703779429,0.672914106028247,0.427816716131132,-5.85092875713902,0.25864251518062,"LOC102724426///USP4","Sjoegren syndrome nuclear autoantigen 1 homolog///ubiquitin specific peptidase 4",TRUE
+"1562718_at",0.936645656431844,0.717136801402738,0.366951102520383,-5.8743108798458,0.28634322362116,"LOC102724449","uncharacterized LOC102724449",TRUE
+"244609_at",0.740610299769501,0.230349642521376,1.23340570449558,-5.22469707916826,0.712665594567417,"LOC102724487","uncharacterized LOC102724487",TRUE
+"241046_at",0.758081075834994,0.254876303466758,-1.16887528447894,-5.29527050843217,-0.871567888941972,"LOC102724511","uncharacterized LOC102724511",TRUE
+"238624_at",0.920539081051875,0.662198858652973,-0.442806206359338,-5.84463006645792,-0.172805143080824,"LOC102724517///NLK","uncharacterized LOC102724517///nemo like kinase",TRUE
+"235282_at",0.904832003218088,0.609473188859851,0.518173652534264,-5.80974455391217,0.18759071850207,"LOC102724532///SP2-AS1","uncharacterized LOC102724532///SP2 antisense RNA 1",TRUE
+"244505_at",0.64484773720849,0.115243845322931,-1.63944224717272,-4.70905037050335,-0.556412543640239,"LOC102724537","uncharacterized LOC102724537",TRUE
+"242371_x_at",0.99129194841243,0.95920074130333,-0.0517384293455195,-5.93837976257054,-0.0141639463786785,"LOC102724561","uncharacterized LOC102724561",TRUE
+"213380_x_at",0.728342209206741,0.208611595723412,1.29512060970742,-5.15415445875808,0.996417265945214,"LOC102724562///MST1L///MST1P2///MST1","macrophage stimulating 1 pseudogene///macrophage stimulating 1 like///macrophage stimulating 1 pseudogene 2///macrophage stimulating 1",TRUE
+"240747_at",0.953100284712479,0.784758456647213,0.276458424458938,-5.90252601471758,0.105269422665196,"LOC102724587","uncharacterized LOC102724587",TRUE
+"241299_at",0.994940231134377,0.976105971614961,-0.0302912568288896,-5.93923658086812,-0.022995667314031,"LOC102724611","uncharacterized LOC102724611",TRUE
+"1561245_at",0.972112264314695,0.866249276927664,-0.170390616372883,-5.92555248076304,-0.149098658421801,"LOC102724612","uncharacterized LOC102724612",TRUE
+"1561667_at",0.943177611554239,0.744697719059329,-0.329734392963904,-5.88686595564026,-0.135569108724846,"LOC102724640","uncharacterized LOC102724640",TRUE
+"1553392_at",0.986342822130003,0.935197923027501,-0.0822353865873703,-5.93639017569059,-0.071081858951807,"LOC102724660///EFCAB3","uncharacterized LOC102724660///EF-hand calcium binding domain 3",TRUE
+"239624_at",0.73936001229895,0.227075140860063,-1.24240858359804,-5.21459048373871,-1.63039529841234,"LOC102724689","uncharacterized LOC102724689",TRUE
+"1569405_at",0.789595899448337,0.316917147506868,1.02393259565294,-5.44153588284792,0.60360555243741,"LOC102724708","uncharacterized LOC102724708",TRUE
+"239287_at",0.744931128252932,0.236558058552098,1.2165997167861,-5.24339359854013,0.605069397834048,"LOC102724714","uncharacterized LOC102724714",TRUE
+"1564151_at",0.958587459575795,0.812201198172659,0.240438324407325,-5.91156523563665,0.253883876277993,"LOC102724718","uncharacterized LOC102724718",TRUE
+"244765_at",0.414637020271776,0.0167647494982189,-2.58706198429284,-3.11872299809995,-1.04790429341443,"LOC102724782","uncharacterized LOC102724782",TRUE
+"214203_s_at",0.7580782491858,0.254758660275078,-1.16917347040951,-5.29495200324646,-2.00272804664014,"LOC102724788///PRODH","proline dehydrogenase 1, mitochondrial///proline dehydrogenase 1",TRUE
+"243892_at",0.979388236370534,0.900802190220436,0.126084477414084,-5.93194345931438,0.106611570625651,"LOC102724809","uncharacterized LOC102724809",TRUE
+"1557263_s_at",0.856690614892852,0.470858288815714,-0.733643585963572,-5.68087619478993,-0.390020376140741,"LOC102724814","uncharacterized LOC102724814",TRUE
+"1557262_at",0.998870448604467,0.996154662740578,-0.00487410346322724,-5.93967190965316,-0.00310394022393812,"LOC102724814","uncharacterized LOC102724814",TRUE
+"231557_at",0.86830853559474,0.50249932098314,-0.681689522029871,-5.71584468944412,-0.472828092517521,"LOC102724842","uncharacterized LOC102724842",TRUE
+"230187_s_at",0.937113154905832,0.719457023686913,-0.36379831593976,-5.87542584595706,-0.255928295035696,"LOC102724851","uncharacterized LOC102724851",TRUE
+"236353_at",0.627021415091472,0.0975663340468058,1.72984332971091,-4.57868615726555,1.46111483598035,"LOC102724851///LOC101927268","uncharacterized LOC102724851///uncharacterized LOC101927268",TRUE
+"224375_at",0.686108994812404,0.154591455679577,1.47383976564339,-4.93368105388627,0.632991640157675,"LOC102724870","uncharacterized LOC102724870",TRUE
+"240069_at",0.9802233499944,0.907181487108047,0.117935373353376,-5.93291131012095,0.0476178841206663,"LOC102724880","uncharacterized LOC102724880",TRUE
+"1568763_s_at",0.808257777979515,0.350807381400421,-0.953130169455623,-5.50663680712601,-0.512838380660654,"LOC102724884///LOC728613///PDCD6","uncharacterized LOC102724884///programmed cell death 6 pseudogene///programmed cell death 6",TRUE
+"1565802_at",0.86481525165637,0.49224486799785,0.698315202837867,-5.70492080457697,0.231576374009962,"LOC102724891","uncharacterized LOC102724891",TRUE
+"1569577_x_at",0.827985973549523,0.397469197216359,-0.862839743070592,-5.58343190974576,-0.838154596359294,"LOC102724927","uncharacterized LOC102724927",TRUE
+"237490_at",0.73148417124022,0.214674665402123,-1.2774287162602,-5.1746778020416,-1.08632587479771,"LOC102724938","uncharacterized LOC102724938",TRUE
+"225062_at",0.837067957688307,0.419234604130244,0.823078115845747,-5.61499819889221,0.566307709832341,"LOC102724951///LOC389831","uncharacterized LOC102724951///uncharacterized LOC389831",TRUE
+"225046_at",0.956734254923335,0.80405757839504,0.251091204945097,-5.90902228097182,0.198753183459027,"LOC102724951///LOC389831","uncharacterized LOC102724951///uncharacterized LOC389831",TRUE
+"239011_at",0.712948021516228,0.187165183640428,-1.36110185538118,-5.07551471883397,-0.966516256418311,"LOC102724965","collagen alpha-2(I) chain-like",TRUE
+"243199_at",0.567292616148537,0.0574249128047221,2.00418091734684,-4.15240534410542,1.16580693291063,"LOC102724975","collagen alpha-3(IV) chain-like",TRUE
+"224706_at",0.81853594622567,0.371803204837943,0.911577092621298,-5.54285458043519,0.351755036349708,"LOC102724984///KIAA2013","uncharacterized protein KIAA2013///KIAA2013",TRUE
+"212053_at",0.697412165374288,0.167916777796154,-1.42561385171616,-4.9954862765539,-0.604528467113479,"LOC102724985///PDXDC1","pyridoxal-dependent decarboxylase domain-containing protein 1///pyridoxal dependent decarboxylase domain containing 1",TRUE
+"232288_at",0.960664106415106,0.821348044233755,-0.22850685481492,-5.91428324563269,-0.18102953196714,"LOC102724985///PDXDC2P///PDXDC1","pyridoxal-dependent decarboxylase domain-containing protein 1///pyridoxal dependent decarboxylase domain containing 2, pseudogene///pyridoxal dependent decarboxylase domain containing 1",TRUE
+"214870_x_at",0.6708432030569,0.136706574255557,-1.54418784394017,-4.84056339531801,-0.653092093433026,"LOC102724993///LOC101930075///NPIPA8///NPIPA7///NPIPA5///NPIPA2///NPIPA3///PKD1P1///NPIPA1","nuclear pore complex-interacting protein family member A7-like///polycystin-1-like///nuclear pore complex interacting protein family member A8///nuclear pore complex interacting protein family member A7///nuclear pore complex interacting protein family member A5///nuclear pore complex interacting protein family member A2///nuclear pore complex interacting protein family member A3///polycystin 1, transient receptor potential channel interacting pseudogene 1///nuclear pore complex interacting protein family member A1",TRUE
+"241799_x_at",0.707898177720919,0.179747964169617,1.38530676302088,-5.04584762408492,0.451411683214484,"LOC102725022","uncharacterized LOC102725022",TRUE
+"239518_at",0.791646964605038,0.322212953255002,1.01253403240443,-5.45230233143164,0.623002106842691,"LOC102725022","uncharacterized LOC102725022",TRUE
+"243204_at",0.938034425016976,0.725724424904832,0.355300628351039,-5.878383692313,0.286162883812953,"LOC102725022","uncharacterized LOC102725022",TRUE
+"1569607_s_at",0.947926063538122,0.762646544722356,-0.30575351862985,-5.89425257496046,-0.191193091632151,"LOC102725051///LOC102723891///ANKRD20A4///ANKRD20A2///ANKRD20A3///ANKRD20A5P///ANKRD20A11P///ANKRD20A9P///ANKRD20A1","uncharacterized LOC102725051///ankyrin repeat domain-containing protein 20B-like///ankyrin repeat domain 20 family member A4///ankyrin repeat domain 20 family member A2///ankyrin repeat domain 20 family member A3///ankyrin repeat domain 20 family member A5, pseudogene///ankyrin repeat domain 20 family member A11, pseudogene///ankyrin repeat domain 20 family member A9, pseudogene///ankyrin repeat domain 20 family member A1",TRUE
+"231528_at",0.30050033261608,0.0056855072601748,3.06150986924107,-2.18308638918442,1.59354146307836,"LOC102725068","uncharacterized LOC102725068",TRUE
+"1559952_x_at",0.658800626791833,0.12693264890282,-1.58589645304003,-4.78373393078823,-0.819126803404015,"LOC102725108///LOC101928910///FAM66D///FAM66B///FAM66C","uncharacterized LOC102725108///uncharacterized LOC101928910///family with sequence similarity 66 member D///family with sequence similarity 66 member B///family with sequence similarity 66 member C",TRUE
+"1559950_at",0.996261754016157,0.982012523259127,-0.0228017450633706,-5.93943025026474,-0.0125355140643189,"LOC102725108///LOC101928910///FAM66D///FAM66B///FAM66C","uncharacterized LOC102725108///uncharacterized LOC101928910///family with sequence similarity 66 member D///family with sequence similarity 66 member B///family with sequence similarity 66 member C",TRUE
+"1568785_a_at",0.819018525257656,0.374063727344501,-0.907197517024735,-5.54658520619812,-0.659048643689937,"LOC102725116","uncharacterized LOC102725116",TRUE
+"1568784_at",0.832792886465252,0.409693640840315,0.840342076842099,-5.60146331362854,0.578360571499196,"LOC102725116","uncharacterized LOC102725116",TRUE
+"216469_at",0.792243446641505,0.323058948978548,-1.01072527824287,-5.45400075344699,-0.726750329709226,"LOC102725136///LOC441666","putative zinc finger protein ENSP00000328166-like///zinc finger protein 91 pseudogene",TRUE
+"1570140_at",0.710672261019989,0.18368872421116,1.37235032849375,-5.06178196201162,0.603763679741523,"LOC102725207///LOC100996760///ANXA8L1///ANXA8","annexin A8-like///uncharacterized LOC100996760///annexin A8-like 1///annexin A8",TRUE
+"215133_s_at",0.937113154905832,0.720742654151213,0.362052981584893,-5.87603898937948,0.223001566092702,"LOC102725213///LOC100507387///FAM153A///FAM153B","uncharacterized LOC102725213///uncharacterized LOC100507387///family with sequence similarity 153 member A///family with sequence similarity 153 member B",TRUE
+"59433_at",0.73223722457785,0.21618016332085,1.27309555220995,-5.1796677747018,0.48066977073595,"LOC102725263///LOC389906","uncharacterized LOC102725263///zinc finger protein 839 pseudogene",TRUE
+"222020_s_at",0.778580821633075,0.298850308904959,1.06385854607961,-5.40296846998735,0.764352743667182,"LOC102725271///NTM","neurotrimin-like///neurotrimin",TRUE
+"227566_at",0.786258836947875,0.311656177674154,1.03538917523978,-5.4306050011655,0.66938879756449,"LOC102725271///NTM","neurotrimin-like///neurotrimin",TRUE
+"215732_s_at",0.274674111480702,0.00437067173275192,3.1736119679329,-1.95330964802857,1.05621618862479,"LOC102725292///DTX2","probable E3 ubiquitin-protein ligase DTX2-like///deltex E3 ubiquitin ligase 2",TRUE
+"214570_x_at",0.921006039723366,0.663772601763783,-0.440598322029043,-5.84557120598366,-0.301728698825947,"LOC102725315///LOC102725072///LOC727983///POM121L10P///POM121L4P///POM121L8P///POM121L9P///POM121L1P","putative POM121-like protein 1-like///uncharacterized LOC102725072///putative POM121-like protein 1-like///POM121 transmembrane nucleoporin like 10, pseudogene///POM121 transmembrane nucleoporin like 4, pseudogene///POM121 transmembrane nucleoporin like 8, pseudogene///POM121 transmembrane nucleoporin like 9, pseudogene///POM121 transmembrane nucleoporin like 1, pseudogene",TRUE
+"1553818_x_at",0.830592576740524,0.403239777209265,0.852165277178134,-5.59204262786837,0.663407478212133,"LOC102725315///LOC727983///POM121L10P///POM121L4P///POM121L8P///POM121L9P///POM121L1P","putative POM121-like protein 1-like///putative POM121-like protein 1-like///POM121 transmembrane nucleoporin like 10, pseudogene///POM121 transmembrane nucleoporin like 4, pseudogene///POM121 transmembrane nucleoporin like 8, pseudogene///POM121 transmembrane nucleoporin like 9, pseudogene///POM121 transmembrane nucleoporin like 1, pseudogene",TRUE
+"1553817_at",0.915078108213431,0.642150584804437,0.471134257216007,-5.83214577743342,0.346578348208916,"LOC102725315///LOC727983///POM121L10P///POM121L4P///POM121L8P///POM121L9P///POM121L1P","putative POM121-like protein 1-like///putative POM121-like protein 1-like///POM121 transmembrane nucleoporin like 10, pseudogene///POM121 transmembrane nucleoporin like 4, pseudogene///POM121 transmembrane nucleoporin like 8, pseudogene///POM121 transmembrane nucleoporin like 9, pseudogene///POM121 transmembrane nucleoporin like 1, pseudogene",TRUE
+"238163_at",0.824753941545492,0.392216318868301,0.872643730237156,-5.57543554394054,0.421408809797364,"LOC102725343","uncharacterized LOC102725343",TRUE
+"242215_at",0.819780516863333,0.377601987000395,-0.900377412060007,-5.55236168784377,-0.587608553556785,"LOC102725345","uncharacterized LOC102725345",TRUE
+"1560920_s_at",0.425751189365875,0.0181451375015694,2.55124971472915,-3.18640760639987,1.46839469595135,"LOC102725382","uncharacterized LOC102725382",TRUE
+"232047_at",0.665347414601538,0.132777423698535,1.56064839036216,-4.81827760783371,0.620826004855053,"LOC102725383","uncharacterized LOC102725383",TRUE
+"237113_at",0.94632739401154,0.757223113692645,0.312979675290402,-5.89208488872464,0.0957925653782121,"LOC102725408","uncharacterized LOC102725408",TRUE
+"1566427_at",0.740258721846281,0.228634594706464,-1.23810880334647,-5.21942529659378,-0.626261817183947,"LOC102725420///LOC102724888","uncharacterized LOC102725420///uncharacterized LOC102724888",TRUE
+"228518_at",0.930899509890345,0.694523284038862,-0.397884110494734,-5.862868442053,-0.297819089947073,"LOC102725426///MIR8071-2///MIR8071-1///IGHM///IGHG1","uncharacterized LOC102725426///microRNA 8071-2///microRNA 8071-1///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"231521_at",0.994655471321262,0.975189877278029,0.031453013115099,-5.93920164456158,0.0225534545459745,"LOC102725436///PMS2P4","putative postmeiotic segregation increased 2-like protein 1-like///PMS1 homolog 2, mismatch repair system component pseudogene 4",TRUE
+"1570237_at",0.881970070870254,0.53930379446642,0.623528560593484,-5.7520729417613,0.175581874628615,"LOC102725438","uncharacterized LOC102725438",TRUE
+"1569348_at",0.853793505235478,0.462621756279369,0.747500212820468,-5.6711377382066,0.471376899486859,"LOC102725451///TPTEP1","uncharacterized LOC102725451///transmembrane phosphatase with tensin homology pseudogene 1",TRUE
+"237872_at",0.962808206628386,0.831052724195947,-0.21588466441911,-5.91700878546697,-0.0663732708085281,"LOC102725454","uncharacterized LOC102725454",TRUE
+"211646_at",0.849935057946582,0.451442162815471,0.766545761065254,-5.65747104815946,0.548463227976454,"LOC102725526///IGHM///IGHG3///IGHG2///IGHG1///IGHA1///IGH","uncharacterized LOC102725526///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 2 (G2m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"217281_x_at",0.974884920935236,0.877141472645702,-0.156390469473273,-5.92777791736469,-0.0994271480608138,"LOC102725526///IGHV4-31///IGHM///IGHG3///IGHG2///IGHG1///IGHA2///IGHA1///IGH","uncharacterized LOC102725526///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 3 (G3m marker)///immunoglobulin heavy constant gamma 2 (G2m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)///immunoglobulin heavy constant alpha 2 (A2m marker)///immunoglobulin heavy constant alpha 1///immunoglobulin heavy locus",TRUE
+"1563185_at",0.918373706340477,0.653324602037108,-0.455298705811275,-5.83921806625364,-0.251983398996556,"LOC102800447///LOC101930566","uncharacterized LOC102800447///uncharacterized LOC101930566",TRUE
+"1568609_s_at",0.754491163266461,0.247757372570389,1.1871070592217,-5.27566586325141,1.55364210618865,"LOC103091866///LINC00623///LINC01138///LINC00869","uncharacterized LOC103091866///long intergenic non-protein coding RNA 623///long intergenic non-protein coding RNA 1138///long intergenic non-protein coding RNA 869",TRUE
+"213739_at",0.954096423385239,0.789298091386492,0.270475361812628,-5.90411412414657,0.101760060330983,"LOC103344931","uncharacterized LOC103344931",TRUE
+"235660_at",0.993230356651293,0.968524489526542,0.0399072457024851,-5.93890781949578,0.0316108494756069,"LOC103611081","uncharacterized LOC103611081",TRUE
+"240032_at",0.695005304830231,0.16464030559051,1.43717748848841,-4.98081937329594,0.425791775107354,"LOC105274304","uncharacterized LOC105274304",TRUE
+"1560628_at",0.634202341398092,0.105296063447617,-1.6887362089509,-4.63862025535451,-1.2796691839305,"LOC105369167","uncharacterized LOC105369167",TRUE
+"1559940_s_at",0.654126603493344,0.123240203796707,1.60234954565465,-4.76099042911147,0.6529642085432,"LOC105369167","uncharacterized LOC105369167",TRUE
+"1559939_at",0.737123149977386,0.222886899656707,1.25406906730935,-5.20140655914059,0.894089764231827,"LOC105369167","uncharacterized LOC105369167",TRUE
+"230374_at",0.735615890266908,0.220604832239965,1.26049322190029,-5.19409795326675,0.883749153275714,"LOC105369340","uncharacterized LOC105369340",TRUE
+"1558512_at",0.954387719376857,0.79003448287022,0.269505782227976,-5.90436823533245,0.123377501271304,"LOC105369477","uncharacterized LOC105369477",TRUE
+"240628_at",0.913233126230689,0.636152714462266,0.479684730573129,-5.82822868009029,0.315662459868278,"LOC105369507","uncharacterized LOC105369507",TRUE
+"242267_x_at",0.976994788692278,0.890288001207572,-0.139534996615577,-5.93020480120003,-0.0703558580496821,"LOC105369595","uncharacterized LOC105369595",TRUE
+"240284_x_at",0.963252094354226,0.832665620197738,0.213790412757288,-5.91744609511832,0.155364355105978,"LOC105369635","uncharacterized LOC105369635",TRUE
+"1558740_s_at",0.993213867476782,0.967649316675313,0.0410175037164024,-5.93886406161713,0.0298522388215163,"LOC105369662","uncharacterized LOC105369662",TRUE
+"243783_at",0.893635011091274,0.569052792367105,0.578059985774765,-5.7782272670173,0.241130436134941,"LOC105369705","uncharacterized LOC105369705",TRUE
+"242159_at",0.951339758531576,0.777377931855516,0.286207824913337,-5.89986431209361,0.0758614575478029,"LOC105369739","uncharacterized LOC105369739",TRUE
+"1563707_at",0.819018525257656,0.37422200816756,-0.90689151778789,-5.54684524363671,-0.368069088388273,"LOC105369748","uncharacterized LOC105369748",TRUE
+"1568711_a_at",0.990810941805126,0.953681977057412,-0.0587448110176943,-5.9380027886386,-0.0537256270924116,"LOC105369860","uncharacterized LOC105369860",TRUE
+"240919_at",0.959203345279235,0.815327607953607,0.236356198761301,-5.91251063337576,0.11169077373631,"LOC105369921","uncharacterized LOC105369921",TRUE
+"1565741_at",0.825648186672984,0.393216142375299,0.870771142072065,-5.57696935899312,0.522854511760253,"LOC105369974","uncharacterized LOC105369974",TRUE
+"1556297_a_at",0.936143408699214,0.715297050115494,0.36945370551521,-5.8734190868946,0.251171314973286,"LOC105370178","uncharacterized LOC105370178",TRUE
+"237791_at",0.980084804016714,0.906495456888766,0.118811326373223,-5.93281037163787,0.0787925964859344,"LOC105370178","uncharacterized LOC105370178",TRUE
+"1556296_at",0.988615794105123,0.945147438018635,-0.0695859545221892,-5.93732529637058,-0.0206573199198115,"LOC105370178","uncharacterized LOC105370178",TRUE
+"1560482_at",0.879960488971225,0.535143484192825,0.629991871979141,-5.74820021914111,0.463554328160575,"LOC105370424","uncharacterized LOC105370424",TRUE
+"1559813_at",0.48580305784244,0.0285660292980388,-2.34203901752791,-3.57177823490414,-1.36724264223946,"LOC105370475","uncharacterized LOC105370475",TRUE
+"1560557_at",0.992093589969215,0.963333309400377,-0.0464936586715729,-5.93863067056323,-0.0321621531335872,"LOC105370549","uncharacterized LOC105370549",TRUE
+"1563310_a_at",0.71611852101483,0.191816291545719,1.34630764864376,-5.09343255796421,1.18852054562093,"LOC105370580","uncharacterized LOC105370580",TRUE
+"1560325_at",0.990810941805126,0.954901408942897,0.0571964268452437,-5.93809021281679,0.0336444915870122,"LOC105370612","uncharacterized LOC105370612",TRUE
+"1561333_at",0.483342512055348,0.0276886063328662,2.35664814105394,-3.54545755484618,1.53933791526504,"LOC105370613","uncharacterized LOC105370613",TRUE
+"1556374_s_at",0.95877806139143,0.813095580517065,-0.239270113806395,-5.9118374311506,-0.137577332833052,"LOC105370622","uncharacterized LOC105370622",TRUE
+"1562671_s_at",0.283622246282531,0.00479266603757344,-3.13444118912869,-2.03390850202212,-1.61259838497587,"LOC105370629","uncharacterized LOC105370629",TRUE
+"1562670_at",0.506114211039982,0.0331762840853644,2.2714568096695,-3.6976098721293,1.41375088900586,"LOC105370629","uncharacterized LOC105370629",TRUE
+"1569122_at",0.522667179791589,0.0384737887061823,-2.2006708641915,-3.82150411506497,-2.18103461048838,"LOC105370697","uncharacterized LOC105370697",TRUE
+"1560717_at",0.971943273048675,0.865679328770173,-0.171124127798972,-5.9254306402786,-0.171495508723649,"LOC105370737","uncharacterized LOC105370737",TRUE
+"1561897_at",0.767727587789514,0.270208995687311,1.13085443560587,-5.33529701901247,0.772580319684017,"LOC105370746","uncharacterized LOC105370746",TRUE
+"237494_at",0.744931128252932,0.23653056588284,-1.21667339844826,-5.24331211245474,-0.412989955263809,"LOC105370829","uncharacterized LOC105370829",TRUE
+"1561493_at",0.728385463227073,0.208965897090969,-1.29407590581945,-5.1553730262669,-1.18518511373224,"LOC105370832","uncharacterized LOC105370832",TRUE
+"234327_at",0.707694888507328,0.179205043098015,-1.38710939921412,-5.04362082889175,-0.604031825874578,"LOC105370888","uncharacterized LOC105370888",TRUE
+"1561292_at",0.8552783609358,0.467667907866559,0.738993700963794,-5.67713660795059,0.533720992371,"LOC105370941","uncharacterized LOC105370941",TRUE
+"1568650_a_at",0.683017520100356,0.151268125128481,-1.48638970007966,-4.91732434926947,-0.544629370980958,"LOC105370943","uncharacterized LOC105370943",TRUE
+"1568649_at",0.988802593747325,0.946177655778854,0.0682768756586927,-5.93741317814059,0.0193558916413181,"LOC105370943","uncharacterized LOC105370943",TRUE
+"231141_at",0.899808883319249,0.592179667459165,-0.543548519718376,-5.79679864495153,-0.339633209655173,"LOC105370962","uncharacterized LOC105370962",TRUE
+"231516_at",0.974435013896831,0.874899638318365,-0.159269275016255,-5.9273358427451,-0.122375622271837,"LOC105371038","uncharacterized LOC105371038",TRUE
+"237004_at",0.788713938376551,0.314920811713323,1.02826407857392,-5.43741605697423,0.380219064300909,"LOC105371046","uncharacterized LOC105371046",TRUE
+"244843_x_at",0.941908206900417,0.739084788092737,-0.337273644684504,-5.88442970748674,-0.167959563845654,"LOC105371226","uncharacterized LOC105371226",TRUE
+"1561021_at",0.597654932724127,0.0736184832138684,1.87791222914603,-4.3541015271144,2.10296501873085,"LOC105371307","uncharacterized LOC105371307",TRUE
+"1566680_at",0.760244814241272,0.25854809261427,-1.15961947889134,-5.30512162607086,-0.696726143496824,"LOC105371352","uncharacterized LOC105371352",TRUE
+"237015_at",0.922168942129244,0.667817557537903,0.43493361058536,-5.84796473994199,0.267926031008176,"LOC105371352","uncharacterized LOC105371352",TRUE
+"232394_at",0.831487912516861,0.405800654630153,0.847459510973985,-5.59580687624264,0.558735877940433,"LOC105371374","uncharacterized LOC105371374",TRUE
+"1558803_at",0.755868740464627,0.250335260213285,1.18046042783079,-5.28284368822648,1.03707670417453,"LOC105371401","uncharacterized LOC105371401",TRUE
+"239211_at",0.918041148686074,0.651816333708815,0.457429209961651,-5.83828035633388,0.20339765647245,"LOC105371414","uncharacterized LOC105371414",TRUE
+"1569306_at",0.710672261019989,0.18364954541826,1.37247805162242,-5.06162549031877,0.974695007749705,"LOC105371622","uncharacterized LOC105371622",TRUE
+"1569307_s_at",0.740321726337106,0.228852089368957,1.23751089506049,-5.22009646112461,0.807688850944307,"LOC105371622","uncharacterized LOC105371622",TRUE
+"239195_at",0.536422380101288,0.0432194178335096,2.14441601842779,-3.91824791040199,2.71736800724987,"LOC105371703","uncharacterized LOC105371703",TRUE
+"1568904_at",0.700890836612645,0.172595832458209,1.40940992690993,-5.01587515106012,0.871980292580943,"LOC105371708","uncharacterized LOC105371708",TRUE
+"227571_at",0.686108994812404,0.15468690747927,-1.47348256107069,-4.9341449702103,-0.891760284536991,"LOC105371763","uncharacterized LOC105371763",TRUE
+"239332_at",0.820288124919738,0.378602628535369,0.898456292026824,-5.55398156183504,0.547844732915258,"LOC105371809","uncharacterized LOC105371809",TRUE
+"240392_at",0.961395512423249,0.824953495450798,-0.223813178360119,-5.91531475839463,-0.221572336248673,"LOC105371920","uncharacterized LOC105371920",TRUE
+"1556769_a_at",0.53309539883286,0.0420542336036866,2.15769015216116,-3.89556034001384,2.29553413408071,"LOC105371967","uncharacterized LOC105371967",TRUE
+"1563190_at",0.627092759817312,0.0981862163745775,1.72644633457845,-4.58367978772891,1.29898601988004,"LOC105372069","uncharacterized LOC105372069",TRUE
+"242867_x_at",0.724623760403195,0.202046119870861,-1.31473356722047,-5.1311228415878,-0.811890631733445,"LOC105372179","uncharacterized LOC105372179",TRUE
+"241941_at",0.88082806716658,0.536535856404496,0.627825735075379,-5.74950242038826,0.339693198790046,"LOC105372255","uncharacterized LOC105372255",TRUE
+"1562825_at",0.708894565317004,0.181249624936949,1.38034328462066,-5.05196659564915,0.76726369448502,"LOC105372404","uncharacterized LOC105372404",TRUE
+"236093_at",0.618124814816155,0.0890481557789202,1.77850028665291,-4.50636472660227,1.14317607321937,"LOC105372482","uncharacterized LOC105372482",TRUE
+"1562693_at",0.844355787494954,0.441103509066637,0.784414114585305,-5.64435393040267,0.627370349422895,"LOC105372520","uncharacterized LOC105372520",TRUE
+"232406_at",0.552420073963858,0.0501272545021349,2.07176759634419,-4.04083546314991,1.63706802293333,"LOC105372526","uncharacterized LOC105372526",TRUE
+"1557739_at",0.820536502908875,0.380680443638637,0.894477760077633,-5.55732605298071,0.588979623350724,"LOC105372547","uncharacterized LOC105372547",TRUE
+"1561309_x_at",0.533516559925669,0.0422324585525065,-2.15563839941046,-3.89907283186677,-1.4364892387442,"LOC105372550","uncharacterized LOC105372550",TRUE
+"1561307_at",0.819807973515613,0.377843940991837,0.899912580449327,-5.5527539237385,0.450664129444923,"LOC105372550","uncharacterized LOC105372550",TRUE
+"1556867_at",0.89316156038085,0.567266495412627,-0.58075480786967,-5.77673050903702,-0.453029235834244,"LOC105372607","uncharacterized LOC105372607",TRUE
+"237913_at",0.839519981963042,0.427415060689829,0.80847167165002,-5.62624403080188,0.267061368794261,"LOC105372695","uncharacterized LOC105372695",TRUE
+"1563069_at",0.812302873476553,0.359540399869645,0.935649272577832,-5.52205394773239,0.371851696163309,"LOC105372761","uncharacterized LOC105372761",TRUE
+"1562418_at",0.724630969402292,0.202088212555028,1.31460625654113,-5.13127328744652,1.03472055911169,"LOC105372762","uncharacterized LOC105372762",TRUE
+"1560107_at",0.870980161749509,0.511032640875438,0.668000075380438,-5.72465035120747,0.538930045331364,"LOC105372793","uncharacterized LOC105372793",TRUE
+"1568817_at",0.724970327905974,0.203064263130258,1.3116599349814,-5.13475158167796,0.759880584534645,"LOC105372840","uncharacterized LOC105372840",TRUE
+"1556107_at",0.895690630367785,0.576075210936422,-0.567507423251578,-5.7840234627594,-0.295713172970984,"LOC105372881","uncharacterized LOC105372881",TRUE
+"1563235_at",0.65284137151906,0.122102392834635,1.60750232300679,-4.75383010968734,1.11156376732545,"LOC105372953","uncharacterized LOC105372953",TRUE
+"1561076_at",0.708894565317004,0.181381841435755,1.37990783097702,-5.05250255293107,0.810866453562118,"LOC105372969","uncharacterized LOC105372969",TRUE
+"1560511_at",0.877488742289724,0.527513426105768,-0.641916542138276,-5.74095431419784,-0.281438409645032,"LOC105373065","uncharacterized LOC105373065",TRUE
+"1561036_at",0.910053424070078,0.625571719219552,-0.49485825637841,-5.82110791994249,-0.450587590112572,"LOC105373113","uncharacterized LOC105373113",TRUE
+"1561037_a_at",0.920800738105699,0.663287868751756,0.441278141025631,-5.84528191616733,0.199545862131506,"LOC105373113","uncharacterized LOC105373113",TRUE
+"1570120_at",0.748760747870936,0.241895005343862,-1.20241720887402,-5.25899864281153,-0.872604402019564,"LOC105373150","uncharacterized LOC105373150",TRUE
+"237048_at",0.110991055948466,0.000548103979992422,-4.03453818352792,-0.126176522229207,-3.51946418326098,"LOC105373383","uncharacterized LOC105373383",TRUE
+"1563142_at",0.831943055644609,0.408021088927484,-0.843394653807804,-5.59904279310459,-0.312677724218979,"LOC105373418","uncharacterized LOC105373418",TRUE
+"1561598_at",0.947778780715578,0.761771023993933,0.306918924474662,-5.8939063723536,0.118533655736759,"LOC105373434","uncharacterized LOC105373434",TRUE
+"234433_at",0.986143546287878,0.931932106245828,-0.0863903163370188,-5.93604904260418,-0.0722794489685863,"LOC105373460","uncharacterized LOC105373460",TRUE
+"1568795_at",0.933809945444433,0.706637612364778,-0.381265746688209,-5.86912919209523,-0.351349074618455,"LOC105373495","uncharacterized LOC105373495",TRUE
+"216110_x_at",0.769258076576208,0.276195173971499,-1.11644056318075,-5.35016590887294,-0.52903524622633,"LOC105373738","uncharacterized LOC105373738",TRUE
+"216108_at",0.955515814503015,0.796071602493792,-0.261566779511557,-5.90641482604339,-0.232110178942571,"LOC105373738","uncharacterized LOC105373738",TRUE
+"237375_at",0.779854829728531,0.301109685846665,1.05877351679903,-5.40795410461517,0.584629463817884,"LOC105373764","uncharacterized LOC105373764",TRUE
+"227837_at",0.451974019443452,0.0217188081027027,-2.46918441072683,-3.33967800153015,-0.794312144939854,"LOC105373849","uncharacterized LOC105373849",TRUE
+"233828_at",0.771158062322823,0.280149481893433,1.10704365719514,-5.35976845439298,0.910401572715085,"LOC105373860","uncharacterized LOC105373860",TRUE
+"1560634_a_at",0.800179799309599,0.335856938187139,0.983755486961295,-5.47899838238557,0.596168024111551,"LOC105373876","uncharacterized LOC105373876",TRUE
+"232750_at",0.908291023645058,0.618983512409965,0.50436559846828,-5.81653588904789,0.315906975017854,"LOC105373878","uncharacterized LOC105373878",TRUE
+"233038_at",0.920169584950428,0.66035226325481,0.445399744470278,-5.8435186412799,0.297552244493343,"LOC105373942","uncharacterized LOC105373942",TRUE
+"1557774_at",0.676413305074233,0.143123986006067,-1.51812284020828,-4.87546920181323,-1.10591004303094,"LOC105373958","uncharacterized LOC105373958",TRUE
+"1562997_a_at",0.877510999184545,0.527742417470255,0.64155730380939,-5.7411745098764,0.741876256211434,"LOC105374042","uncharacterized LOC105374042",TRUE
+"1561723_at",0.554642754132296,0.0509191958711189,2.06402282266798,-4.05374336319504,0.791961566227091,"LOC105374177","uncharacterized LOC105374177",TRUE
+"1569063_at",0.851319596585235,0.454639563241789,0.761070000056524,-5.66143364814287,0.629565171158372,"LOC105374325","uncharacterized LOC105374325",TRUE
+"229190_at",0.493058629078403,0.029669188654192,-2.32424617159832,-3.60370862147836,-1.25844922542406,"LOC105374366","uncharacterized LOC105374366",TRUE
+"229189_s_at",0.904381089098038,0.607964183995053,-0.520373918656019,-5.80864586559434,-0.258487844155905,"LOC105374366","uncharacterized LOC105374366",TRUE
+"1561432_at",0.407748633394319,0.0156535120489494,-2.61796011998345,-3.05995092573756,-1.10103763288098,"LOC105374419","uncharacterized LOC105374419",TRUE
+"243776_at",0.689168483917391,0.158287524292978,1.46013689509426,-4.95141228183401,1.13733866913228,"LOC105374428","uncharacterized LOC105374428",TRUE
+"230227_at",0.94895689004559,0.768618585819095,-0.297815556662229,-5.89657594392325,-0.136878901419001,"LOC105374587","uncharacterized LOC105374587",TRUE
+"1559316_at",0.635821858586292,0.106830701705915,1.68088162086515,-4.64994876213845,1.83476704629841,"LOC105374676","uncharacterized LOC105374676",TRUE
+"1557897_at",0.899046682581382,0.589042275643837,0.548190478271463,-5.79436528156557,0.166586601928088,"LOC105374690","uncharacterized LOC105374690",TRUE
+"1563397_at",0.986889306520757,0.939269104500849,0.0770579006035902,-5.93679175261757,0.0557038774535581,"LOC105374768","uncharacterized LOC105374768",TRUE
+"1556173_a_at",0.90105641459739,0.597433515287822,-0.535802038351644,-5.80081463573729,-0.370411268598733,"LOC105374809","uncharacterized LOC105374809",TRUE
+"1556172_at",0.902800035502192,0.602378565983639,0.528541050527566,-5.80452801602421,0.523131918544369,"LOC105374809","uncharacterized LOC105374809",TRUE
+"1564144_at",0.935545117413766,0.713050500829747,-0.37251293814374,-5.8723208158176,-0.27094929994472,"LOC105374895","uncharacterized LOC105374895",TRUE
+"1569740_at",0.739007386198624,0.225643426870414,1.24637601223347,-5.21011658899596,1.08559984568869,"LOC105374928","uncharacterized LOC105374928",TRUE
+"1568749_at",0.914746370982129,0.640797438514348,-0.473060148434708,-5.83126951343997,-0.394739922930746,"LOC105374928","uncharacterized LOC105374928",TRUE
+"1556500_a_at",0.622434989367596,0.0925045507382168,1.75829502204871,-4.53657636688793,1.38587722540242,"LOC105374989","uncharacterized LOC105374989",TRUE
+"240749_at",0.990810941805126,0.953923092774403,-0.0584386407021809,-5.93802026064448,-0.0425098487924345,"LOC105375075","uncharacterized LOC105375075",TRUE
+"241476_at",0.64513208805899,0.116224698220519,1.63477839465544,-4.71563138115288,1.02937169349247,"LOC105375115","uncharacterized LOC105375115",TRUE
+"1569344_a_at",0.879948283821082,0.534845071351265,0.630456512725124,-5.7479203320813,0.272016726431952,"LOC105375172","uncharacterized LOC105375172",TRUE
+"1569528_at",0.971943273048675,0.865647048925745,-0.171165674159243,-5.92542372357045,-0.155455411176736,"LOC105375240","uncharacterized LOC105375240",TRUE
+"1556976_s_at",0.635821858586292,0.106816299637735,1.68095488798584,-4.64984327501815,0.449154524978677,"LOC105375273","uncharacterized LOC105375273",TRUE
+"1561264_at",0.990810941805126,0.956402067735649,-0.0552911486247415,-5.93819458433072,-0.0419072196172694,"LOC105375273","uncharacterized LOC105375273",TRUE
+"1561448_at",0.608709711882903,0.0813942163355659,1.82576727966668,-4.43470998739699,1.19690538845433,"LOC105375483","uncharacterized LOC105375483",TRUE
+"1561889_at",0.844169896707408,0.440705051314544,0.785107858771202,-5.64383890796502,0.275218252481865,"LOC105375527","uncharacterized LOC105375527",TRUE
+"1566500_at",0.792436690618566,0.323779380717539,1.00918758258628,-5.45544248835964,0.366149764289586,"LOC105375531","uncharacterized LOC105375531",TRUE
+"1566501_at",0.994145854504594,0.973267103626225,-0.033891548382248,-5.93912403747697,-0.0131742549532818,"LOC105375531","uncharacterized LOC105375531",TRUE
+"1561789_at",0.998709719538178,0.994144337929205,0.00742230307236987,-5.93965664819296,0.00944991721525712,"LOC105375640","uncharacterized LOC105375640",TRUE
+"1568656_at",0.986342822130003,0.934024486340477,0.0837281147514495,-5.93626955149242,0.0296178843497819,"LOC105375677","uncharacterized LOC105375677",TRUE
+"231501_at",0.848600508270547,0.449020757395963,0.770708197523443,-5.6544408984572,0.329029392388018,"LOC105375773","uncharacterized LOC105375773",TRUE
+"1560638_a_at",0.774230543658252,0.288119181396867,1.08839316926453,-5.37861336630539,0.561205949847812,"LOC105375839","uncharacterized LOC105375839",TRUE
+"1560637_at",0.776983560547865,0.296005395899966,1.07030056932078,-5.39662164902439,0.837734264830159,"LOC105375839","uncharacterized LOC105375839",TRUE
+"1559804_at",0.700061364939874,0.171440700565351,-1.41337723225354,-5.01090092849694,-0.917394688123857,"LOC105375875","uncharacterized LOC105375875",TRUE
+"1560424_at",0.842740884226964,0.436529759162174,0.792400611771417,-5.63839896716748,0.882357114992124,"LOC105376037","uncharacterized LOC105376037",TRUE
+"1560794_at",0.966313390701604,0.842747172674549,0.200721841304898,-5.9200790990818,0.0897081109645459,"LOC105376072","uncharacterized LOC105376072",TRUE
+"1561368_at",0.623667408398064,0.0951402290335661,1.74331841808326,-4.5588058002687,0.870011634972226,"LOC105376081","uncharacterized LOC105376081",TRUE
+"1561078_at",0.76912869907427,0.275061716253429,-1.11915213355659,-5.34738162862998,-0.523672302986081,"LOC105376100","uncharacterized LOC105376100",TRUE
+"1556469_s_at",0.805746717966166,0.345909201531951,0.963064075784242,-5.49775924486275,0.723246908973198,"LOC105376166","uncharacterized LOC105376166",TRUE
+"1556468_at",0.955730092376044,0.797325543843685,-0.259919976411408,-5.90683174256194,-0.170941406054818,"LOC105376166","uncharacterized LOC105376166",TRUE
+"1569765_at",0.411110107932987,0.0162801149007858,2.60029353530532,-3.09359692779276,1.66005277916611,"LOC105376292","uncharacterized LOC105376292",TRUE
+"1560590_s_at",0.441703881289794,0.0204391553664962,-2.49701722073348,-3.28798826348438,-0.916858812159844,"LOC105376323","uncharacterized LOC105376323",TRUE
+"1560185_at",0.948429371744093,0.765010904477368,0.302608471964994,-5.89518034715241,0.268329785756342,"LOC105376360","uncharacterized LOC105376360",TRUE
+"233618_at",0.90427866743639,0.606886234299452,0.521947260812325,-5.80785744669156,0.375102134256672,"LOC105376379","uncharacterized LOC105376379",TRUE
+"234120_at",0.929972194057784,0.6907334787634,0.40310622379663,-5.86084676145748,0.410896453536827,"LOC105376379","uncharacterized LOC105376379",TRUE
+"1557007_a_at",0.97589003385521,0.884550369739225,0.146885964578811,-5.92918031720926,0.0764279859406991,"LOC105376530","uncharacterized LOC105376530",TRUE
+"234677_at",0.581128536542197,0.063674715355966,1.95212029121346,-4.23665388273978,1.11263774869185,"LOC105376689","uncharacterized LOC105376689",TRUE
+"234693_at",0.940227139261806,0.732411628629916,-0.346263039735241,-5.88145367185516,-0.241510408843923,"LOC105376689","uncharacterized LOC105376689",TRUE
+"1556195_a_at",0.689950875648652,0.159277281986213,1.45651147329127,-4.95608103095088,0.83567521752935,"LOC105376796","uncharacterized LOC105376796",TRUE
+"229874_x_at",0.391240007651669,0.0131571842746512,2.69566556808847,-2.9106693932908,1.72717993383009,"LOC105376805","uncharacterized LOC105376805",TRUE
+"1567182_at",0.687277721925286,0.15589914517763,-1.46896155181518,-4.9400087315869,-1.57135290113021,"LOC105376944","uncharacterized LOC105376944",TRUE
+"234704_at",0.728262401376535,0.208435502182754,1.29564035582233,-5.15354790350377,0.639186967757457,"LOC105376944","uncharacterized LOC105376944",TRUE
+"1567181_x_at",0.815217400146643,0.366247934877607,-0.922415562880589,-5.53355089726474,-0.857357617591732,"LOC105376944","uncharacterized LOC105376944",TRUE
+"1567183_s_at",0.944646698916914,0.75102012887617,0.321265430893128,-5.88953762740722,0.275782497325463,"LOC105376944","uncharacterized LOC105376944",TRUE
+"1567179_at",0.978928101156583,0.897089697416221,0.130830918616796,-5.93134999026005,0.124768177921549,"LOC105376944","uncharacterized LOC105376944",TRUE
+"234652_at",0.98661350081953,0.937645341087971,-0.0791226393097445,-5.93663473455288,-0.0652584559587037,"LOC105376944","uncharacterized LOC105376944",TRUE
+"238201_at",0.801587742916188,0.338697141464743,-0.977866740919269,-5.48437471414097,-0.461630437900945,"LOC105376975","uncharacterized LOC105376975",TRUE
+"231673_at",0.643515428391208,0.113853725624696,1.64610959685458,-4.69961732440598,0.5259995627166,"LOC105376997","uncharacterized LOC105376997",TRUE
+"1561967_at",0.885312914741353,0.546529584044562,0.61236587201735,-5.75867083940076,0.411897073167086,"LOC105377105","uncharacterized LOC105377105",TRUE
+"242766_at",0.785416908365814,0.310834038650562,1.03719177920768,-5.42887512853966,0.458665740182124,"LOC105377134","uncharacterized LOC105377134",TRUE
+"241101_at",0.998870448604467,0.995092609500161,0.0062203103770008,-5.93966463519282,0.00474147071119901,"LOC105377143","uncharacterized LOC105377143",TRUE
+"1558871_at",0.501591596209182,0.0321772200071606,2.28595315407287,-3.6719495645603,2.14594679012849,"LOC105377276","uncharacterized LOC105377276",TRUE
+"230171_at",0.60998004334651,0.0820697220312402,1.8214444410851,-4.44131961308063,0.838131314669916,"LOC105377348","uncharacterized LOC105377348",TRUE
+"1559103_s_at",0.56669050572983,0.0570991860277208,-2.00702976449527,-4.1477520998976,-1.62985899436231,"LOC105377371","uncharacterized LOC105377371",TRUE
+"1559102_at",0.933938389322633,0.707345486591004,-0.380298106990602,-5.86948562634637,-0.120272171010714,"LOC105377371","uncharacterized LOC105377371",TRUE
+"1557849_at",0.830398314753695,0.402813426683082,0.852950576864933,-5.59141255704757,0.814992575067822,"LOC105377421","uncharacterized LOC105377421",TRUE
+"215298_at",0.839519981963042,0.427325635153534,-0.808630395238953,-5.6261228411204,-0.398678310591005,"LOC105377443","uncharacterized LOC105377443",TRUE
+"1557762_at",0.771177270679058,0.280402453426606,-1.10644579257176,-5.36037696582824,-0.943069089476259,"LOC105377458","uncharacterized LOC105377458",TRUE
+"1562269_at",0.915569510513076,0.643860107656926,0.468703727786848,-5.83324665293767,0.209443812387514,"LOC105377468","uncharacterized LOC105377468",TRUE
+"234424_at",0.847797601020174,0.447340944146577,-0.773603826275659,-5.65232381587865,-0.511711330734427,"LOC105377776","uncharacterized LOC105377776",TRUE
+"1556148_s_at",0.939976205834042,0.73034826963815,0.34904844769517,-5.88051582939772,0.124561158288242,"LOC105377832","uncharacterized LOC105377832",TRUE
+"1556147_at",0.943464796017993,0.746977544024701,0.326677729924079,-5.88783816469306,0.171805211754142,"LOC105377832","uncharacterized LOC105377832",TRUE
+"231390_at",0.969642324744141,0.855137256834634,-0.184709345583462,-5.92307973281814,-0.0968697252947219,"LOC105377832","uncharacterized LOC105377832",TRUE
+"231677_at",0.636147339487472,0.107556650404252,1.67719931651049,-4.65524591535461,1.3989358971208,"LOC105377924","uncharacterized LOC105377924",TRUE
+"1561765_at",0.814362444834356,0.365275255548564,-0.924324521178085,-5.5319017666331,-0.966377727847632,"LOC105377925","uncharacterized LOC105377925",TRUE
+"1561488_at",0.999125210773387,0.997151630110131,0.00361040467441437,-5.93967713187252,0.00339996469610337,"LOC105377938","uncharacterized LOC105377938",TRUE
+"1560844_at",0.836737396752214,0.418514084846507,0.82437315461349,-5.61399201391138,0.53055202428915,"LOC105378052","uncharacterized LOC105378052",TRUE
+"1562945_at",0.755719147268412,0.250047658856658,1.1811994166139,-5.28204737792275,0.927020426840833,"LOC105378130","uncharacterized LOC105378130",TRUE
+"1561340_at",0.93789466363241,0.725457319421951,0.355662236788289,-5.87825923150854,0.309818555551062,"LOC105378311","uncharacterized LOC105378311",TRUE
+"241143_at",0.768852835478002,0.274067717442958,1.12153679363934,-5.34492808338916,0.354590591394143,"LOC105378349","uncharacterized LOC105378349",TRUE
+"1559642_a_at",0.640337040581689,0.111027616610666,1.65987832900267,-4.68004454334234,0.94196902326394,"LOC105378382","uncharacterized LOC105378382",TRUE
+"1559641_at",0.791838559691106,0.322639785203761,1.01162104472635,-5.45315997146496,0.66775024445285,"LOC105378382","uncharacterized LOC105378382",TRUE
+"1561557_at",0.903906029494077,0.605546777289603,-0.523904151874433,-5.80687359240989,-0.272120599334635,"LOC105378419","uncharacterized LOC105378419",TRUE
+"244589_at",0.775805901298839,0.293250901143384,1.07658018911397,-5.39040184612449,0.640831883138374,"LOC105378470","uncharacterized LOC105378470",TRUE
+"1561069_at",0.990918916504081,0.95726603703328,0.0541943247225218,-5.93825306548417,0.0468426072688746,"LOC105378470","uncharacterized LOC105378470",TRUE
+"1570185_at",0.817916967564753,0.370983678351968,0.913169213654861,-5.54149426560695,0.240250572892773,"LOC105378568","uncharacterized LOC105378568",TRUE
+"1556486_at",0.791939701040068,0.322700038399116,1.01149223180809,-5.45328091902691,0.731773579972962,"LOC105378577","basic proline-rich protein-like",TRUE
+"1556401_a_at",0.767727587789514,0.26988695002645,1.13163647212229,-5.33448547459506,0.561152062519059,"LOC105378589","uncharacterized LOC105378589",TRUE
+"1556400_at",0.789661545166663,0.317269457466269,1.02317017114613,-5.44225942606415,0.75111456788415,"LOC105378589","uncharacterized LOC105378589",TRUE
+"1561440_at",0.868313695469383,0.502546439999912,0.681613574223591,-5.7158940137767,0.468347223230346,"LOC105378702","uncharacterized LOC105378702",TRUE
+"1556261_a_at",0.668739504090464,0.135032143065274,1.55115419473334,-4.83115447842809,1.39885955481229,"LOC105378732","uncharacterized LOC105378732",TRUE
+"234127_at",0.878774484192636,0.5319326900279,0.63499857481253,-5.74517386067488,0.267729172077669,"LOC105378749","uncharacterized LOC105378749",TRUE
+"234138_at",0.907964244160782,0.618111344523565,0.505627730113776,-5.81592255253546,0.308823982739967,"LOC105378749","uncharacterized LOC105378749",TRUE
+"234139_s_at",0.934529238427318,0.709533424693384,0.377309602259718,-5.87058081511773,0.152051258124659,"LOC105378749","uncharacterized LOC105378749",TRUE
+"239982_at",0.67368843181164,0.140146267520215,1.53009504587941,-4.85949484899277,1.17365424142273,"LOC105378828","uncharacterized LOC105378828",TRUE
+"234359_at",0.972411709729607,0.867046758816482,-0.169364434263627,-5.92572205969633,-0.0418554701604936,"LOC105378948","uncharacterized LOC105378948",TRUE
+"1560898_at",0.957610494018084,0.809894124177337,0.243453327010569,-5.91085664207764,0.213076926895694,"LOC105378997","basic salivary proline-rich protein 2",TRUE
+"236836_at",0.813065886130395,0.362700451923336,-0.929394213308116,-5.52750687927846,-0.35414100229411,"LOC105379045","uncharacterized LOC105379045",TRUE
+"1570050_at",0.351113781122892,0.00928505731524332,2.84937617153984,-2.60959775242085,2.07843400343403,"LOC105379143","uncharacterized LOC105379143",TRUE
+"1556161_a_at",0.980326403741224,0.908283395232175,0.116528606959986,-5.93307185474353,0.0549695736070515,"LOC105379178","uncharacterized LOC105379178",TRUE
+"1557816_a_at",0.868362470085218,0.503054775539227,0.68079447989582,-5.71642564098562,0.178216523642075,"LOC105379186","uncharacterized LOC105379186",TRUE
+"235696_at",0.466300647363886,0.0243033054125237,2.41733420136731,-3.43514294863174,2.35976200731674,"LOC105379362","uncharacterized LOC105379362",TRUE
+"1569608_x_at",0.996808716460246,0.983809637999594,0.020523287666501,-5.93947832924168,0.0224963208700171,"LOC105379426","ankyrin repeat domain-containing protein 20A2",TRUE
+"227921_at",0.760583978661137,0.259746210325757,1.15662036926059,-5.3082988954211,0.549080127467148,"LOC105379499///FLJ45482","uncharacterized LOC105379499///uncharacterized LOC645566",TRUE
+"216227_at",0.820293495506061,0.379285921008262,0.897146365771507,-5.5550842471161,0.545244562846134,"LOC105379655","uncharacterized LOC105379655",TRUE
+"216229_x_at",0.939452234779565,0.72886796378909,0.351048503957284,-5.8798378330942,0.103896302131275,"LOC105379655","uncharacterized LOC105379655",TRUE
+"236439_at",0.816062298031898,0.367052657214457,-0.920838786766877,-5.53491069124781,-0.596147326476654,"LOC106146153","uncharacterized lncRNA LOC106146153",TRUE
+"1557235_at",0.48580305784244,0.0284703012366997,2.34361266606958,-3.56894752719084,1.17909794350799,"LOC107161159","uncharacterized LOC107161159",TRUE
+"1557149_at",0.960869410126562,0.822103523297859,0.227522919995129,-5.91450124622614,0.0871651873222161,"LOC107984282","uncharacterized LOC107984282",TRUE
+"1557630_s_at",0.873370488504028,0.518591447375041,-0.655980258266089,-5.73224092907575,-0.182358331495618,"LOC107984534","uncharacterized LOC107984534",TRUE
+"226444_at",0.975398143273847,0.881552148180526,-0.150730514470776,-5.9286236132083,-0.0783939841113908,"LOC107985971","uncharacterized LOC107985971",TRUE
+"223797_at",0.854810562588402,0.466775205193358,0.740494585167012,-5.67608290035717,0.351858464636723,"LOC114224","uncharacterized LOC114224",TRUE
+"233582_at",0.678750397006958,0.14628979750032,-1.50561631237906,-4.89204952459941,-0.700093695963303,"LOC115110","uncharacterized LOC115110",TRUE
+"232190_x_at",0.812302873476553,0.356613288289481,0.941476261953209,-5.51694396920172,0.59260875247317,"LOC115110","uncharacterized LOC115110",TRUE
+"233960_s_at",0.844169896707408,0.440546674870836,-0.785383710508937,-5.64363400171661,-0.261639909955186,"LOC115110","uncharacterized LOC115110",TRUE
+"1552986_at",0.951934441578502,0.77997273968914,0.282776999095534,-5.90081140645349,0.200832200654119,"LOC142937","uncharacterized protein BC008131",TRUE
+"234054_at",0.879716812354048,0.534443047812566,-0.631082700526595,-5.74754281929942,-0.436062303144507,"LOC143188///VTI1A","uncharacterized LOC143188///vesicle transport through interaction with t-SNAREs 1A",TRUE
+"1556078_at",0.755940660414394,0.250576736179141,1.17984044695629,-5.28351142380233,0.57917071010965,"LOC143286","uncharacterized LOC143286",TRUE
+"1565644_at",0.870980161749509,0.51124442339833,0.667661962542466,-5.72486567638542,0.289260384353095,"LOC143286","uncharacterized LOC143286",TRUE
+"230505_at",0.816800680706682,0.368631732687754,0.917751418507115,-5.53756699607708,0.566469654728137,"LOC145474","uncharacterized LOC145474",TRUE
+"216106_at",0.998870448604467,0.995695082655668,0.0054566434923468,-5.93966897847516,0.00389041382968891,"LOC145678","uncharacterized LOC145678",TRUE
+"243622_at",0.868922603945869,0.505365704304978,-0.677076695361699,-5.7188309569981,-0.428026654988417,"LOC145694","uncharacterized LOC145694",TRUE
+"239107_at",0.821137675198948,0.382109034043708,-0.891750607566725,-5.55961065634342,-0.349612052551769,"LOC145783///ZNF280D","uncharacterized LOC145783///zinc finger protein 280D",TRUE
+"221213_s_at",0.828070400350931,0.397869534989428,-0.862095990556627,-5.58403510289754,-0.470841621366395,"LOC145783///ZNF280D","uncharacterized LOC145783///zinc finger protein 280D",TRUE
+"1558202_at",0.862800800218883,0.486563335378484,0.707612151438214,-5.69870279985167,0.237468711160044,"LOC145783///ZNF280D","uncharacterized LOC145783///zinc finger protein 280D",TRUE
+"1558570_at",0.885450069080829,0.547003639419776,0.611636281238514,-5.75909807575863,0.301741938854627,"LOC145783///ZNF280D","uncharacterized LOC145783///zinc finger protein 280D",TRUE
+"229013_at",0.908667507590078,0.620139734124096,0.502693685234649,-5.81734605700941,0.219147316350767,"LOC145783///ZNF280D","uncharacterized LOC145783///zinc finger protein 280D",TRUE
+"1568951_at",0.980459547037842,0.908881824227802,0.115764715327071,-5.93315822643608,0.0501998600785658,"LOC145783///ZNF280D","uncharacterized LOC145783///zinc finger protein 280D",TRUE
+"233382_at",0.535243600695458,0.0427789324769269,2.14939572178553,-3.90974710291367,1.46184060381372,"LOC145845","uncharacterized LOC145845",TRUE
+"233311_at",0.931249918595013,0.695316240087868,-0.396792894760906,-5.86328761451358,-0.1887711303047,"LOC145845","uncharacterized LOC145845",TRUE
+"232577_at",0.689006219250111,0.158002011466994,1.46118611881932,-4.95005935401373,0.964577445645907,"LOC145945","uncharacterized LOC145945",TRUE
+"1562623_at",0.94895689004559,0.768423392152861,-0.298074694257501,-5.89650105333587,-0.177145689488956,"LOC146513","uncharacterized LOC146513",TRUE
+"1564402_at",0.585036027492332,0.0652469504264816,1.93973725309715,-4.25647074348159,1.40502224692258,"LOC146795","uncharacterized LOC146795",TRUE
+"228779_at",0.611335385563865,0.0835016490057785,1.8123819351157,-4.45513956956401,0.850346030822979,"LOC146880","Rho GTPase activating protein 27 pseudogene",TRUE
+"229747_x_at",0.808266620412549,0.351164706528949,0.9524091782407,-5.50727785085854,0.323207994520755,"LOC146880","Rho GTPase activating protein 27 pseudogene",TRUE
+"1564203_at",0.924307191583469,0.673576452864078,0.426893460218637,-5.85130975101174,0.14539638821378,"LOC147004","uncharacterized LOC147004",TRUE
+"240298_at",0.848376789225697,0.448529092635363,-0.771555037812738,-5.65382252306462,-0.374596987365181,"LOC147791","uncharacterized LOC147791",TRUE
+"225920_at",0.967642500113955,0.847861897630713,-0.194105491520733,-5.92134907527411,-0.085041454086122,"LOC148413","uncharacterized LOC148413",TRUE
+"232430_at",0.955992770848185,0.801250456773993,0.254770103309801,-5.90811863750734,0.190004358700051,"LOC148696","uncharacterized LOC148696",TRUE
+"1558577_at",0.937113154905832,0.719546388844455,0.363676959235136,-5.8754685732644,0.142550933525596,"LOC148709","actin pseudogene",TRUE
+"232450_at",0.565795244949651,0.0566864571386885,2.01066035943291,-4.14181557037434,1.34752520917571,"LOC149351","uncharacterized LOC149351",TRUE
+"1552942_at",0.899808883319249,0.593654917347929,0.54136997399617,-5.79793372761434,0.140404256797511,"LOC149373","uncharacterized LOC149373",TRUE
+"232670_at",0.863621091805053,0.48899829465205,0.703620106783669,-5.70138237151488,0.467073340651274,"LOC149401","uncharacterized LOC149401",TRUE
+"1563753_at",0.822173415758858,0.386275913785948,-0.883834053727118,-5.56620594238181,-0.448385907315517,"LOC149684///BPI","uncharacterized LOC149684///bactericidal/permeability-increasing protein",TRUE
+"205557_at",0.854116828440652,0.463575294154146,-0.745888580772014,-5.67227927224262,-0.593050800175341,"LOC149684///BPI","uncharacterized LOC149684///bactericidal/permeability-increasing protein",TRUE
+"244231_at",0.966089564318167,0.84208152129032,0.201583588425365,-5.91991057004861,0.0818129107795853,"LOC149684///BPI","uncharacterized LOC149684///bactericidal/permeability-increasing protein",TRUE
+"236652_at",0.726636642789909,0.206232280493631,1.30217218467995,-5.14590751505827,0.771459532801024,"LOC149703","uncharacterized LOC149703",TRUE
+"1561343_a_at",0.629226960424836,0.10011239741629,1.71600623609351,-4.59898105564694,1.19612075579763,"LOC150005","uncharacterized LOC150005",TRUE
+"1561342_at",0.981335195954425,0.911660000471399,-0.112219303636347,-5.93355167171703,-0.0617675897703118,"LOC150005","uncharacterized LOC150005",TRUE
+"1556344_at",0.975425489438712,0.882548212840304,-0.149453028767852,-5.92881018966464,-0.0849880600766371,"LOC150051","uncharacterized LOC150051",TRUE
+"1553472_at",0.462669793287247,0.0234102933372948,2.43464552757127,-3.40339171061153,1.54863521297021,"LOC150596","uncharacterized LOC150596",TRUE
+"242295_at",0.992376456171815,0.964533051450468,0.0449712857011758,-5.93869848422643,0.0294362608667145,"LOC150596","uncharacterized LOC150596",TRUE
+"207856_s_at",0.480603497646452,0.0271162710618738,-2.36640907304399,-3.5278200845462,-0.582180527935201,"LOC150776///SMPD4","sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) pseudogene///sphingomyelin phosphodiesterase 4",TRUE
+"1560750_at",0.946941640414848,0.759104775067995,-0.310470650445973,-5.89284322555417,-0.234820435827282,"LOC151121","uncharacterized LOC151121",TRUE
+"231135_at",0.666643938027574,0.133507308219746,1.55756049301978,-4.82247248302232,0.562035627745334,"LOC151174","uncharacterized LOC151174",TRUE
+"1562689_at",0.708894565317004,0.180921116234868,1.38142631640727,-5.05063298920027,0.647880174897832,"LOC151484","uncharacterized LOC151484",TRUE
+"1560928_at",0.787929163003677,0.31385671429495,1.03058075053182,-5.43520614694472,0.400852999355695,"LOC151657","uncharacterized LOC151657",TRUE
+"1564838_a_at",0.876632890672003,0.525371377868412,0.645281085292034,-5.73888626366922,0.309330632501481,"LOC151760","putative uncharacterized protein LOC151760",TRUE
+"1564837_at",0.995810088048184,0.979760743285598,0.0256568222029579,-5.93936286555827,0.0106634734958493,"LOC151760","putative uncharacterized protein LOC151760",TRUE
+"1553775_at",0.724652102844753,0.202170265265504,-1.31435814484016,-5.1315664511918,-0.568637742788,"LOC152048","uncharacterized FLJ31715",TRUE
+"1562048_at",0.635368778245437,0.106419252215157,1.68297807482854,-4.64692899618829,1.34643963048669,"LOC152225","uncharacterized LOC152225",TRUE
+"1563572_at",0.736132227107113,0.221531862406163,1.25787746868277,-5.19707769571493,1.11133687513846,"LOC152274","uncharacterized LOC152274",TRUE
+"234869_at",0.620129049200068,0.0898445048439127,-1.77378600821234,-4.51343631525176,-0.957588783805797,"LOC152286","uncharacterized LOC152286",TRUE
+"236124_at",0.812302873476553,0.360080789823815,-0.934577009845882,-5.52299109426724,-0.350809173995692,"LOC153546","uncharacterized LOC153546",TRUE
+"1556750_at",0.880842449447422,0.536661923960463,0.627629759066358,-5.74962002093632,0.300197312491965,"LOC153577","uncharacterized LOC153577",TRUE
+"232794_at",0.808233282592165,0.35026220138745,0.954231163493176,-5.50565704038055,0.646393521272216,"LOC153682","uncharacterized LOC153682",TRUE
+"232645_at",0.863648730667543,0.489037425274093,-0.70355604693319,-5.70142525247968,-0.353288334710266,"LOC153684","uncharacterized LOC153684",TRUE
+"232192_at",0.778580821633075,0.298689891311913,-1.06422062800449,-5.40261264915013,-0.708527636451087,"LOC153811///RNF130","uncharacterized LOC153811///ring finger protein 130",TRUE
+"1561085_at",0.95396321837061,0.787639422531823,-0.27266024222893,-5.90353818071928,-0.119860233736296,"LOC153910","uncharacterized LOC153910",TRUE
+"227868_at",0.552420073963858,0.0496355526054427,-2.07663149465475,-4.03271295168934,-1.50764443197136,"LOC154761","family with sequence similarity 115, member C pseudogene",TRUE
+"213367_at",0.909098669732994,0.623006876168762,0.49855400055425,-5.8193407471389,0.359137417797116,"LOC155060","AI894139 pseudogene",TRUE
+"1563610_at",0.942671206410999,0.742797816081073,0.332284126344498,-5.88604812774311,0.303365909056438,"LOC157273","uncharacterized LOC157273",TRUE
+"230692_at",0.769847953580141,0.277959198413501,1.11223657302186,-5.35447079487287,0.986395928545516,"LOC157503///XKR4","uncharacterized LOC157503///XK related 4",TRUE
+"213776_at",0.976422537443518,0.88777116982035,0.142758529739573,-5.92976200752792,0.106664270595722,"LOC157562","uncharacterized LOC157562",TRUE
+"239877_at",0.865345395265289,0.495057227817218,0.693735998307721,-5.7079546424033,0.446937095794279,"LOC157740","uncharacterized protein C8orf9",TRUE
+"232040_at",0.931582451098271,0.698264793826219,-0.392739567879597,-5.86483470382716,-0.255411451665761,"LOC157860","uncharacterized LOC157860",TRUE
+"1561990_at",0.909441642299191,0.623828738172689,-0.497368995782959,-5.81990877241234,-0.274762252256687,"LOC157931","uncharacterized LOC157931",TRUE
+"1559067_a_at",0.567324179293235,0.0575334165440234,2.00323511717984,-4.15394921609002,0.907094495383083,"LOC158402","uncharacterized LOC158402",TRUE
+"1559066_at",0.734356330624014,0.218688427530319,1.2659274722483,-5.18789057248345,0.75784703261185,"LOC158402","uncharacterized LOC158402",TRUE
+"236769_at",0.748184017928985,0.240474740933254,1.20616823642544,-5.25488681934893,1.08366434693826,"LOC158402","uncharacterized LOC158402",TRUE
+"1563827_at",0.918409982899324,0.653588917048282,0.454925568227503,-5.83938185569375,0.375798193464727,"LOC158434","uncharacterized LOC158434",TRUE
+"232179_at",0.976994788692278,0.890347367926501,0.139458978712107,-5.93021512141635,0.0963521880465175,"LOC158863","uncharacterized LOC158863",TRUE
+"1553914_at",0.929972194057784,0.690793712174928,-0.40302313707194,-5.86087913070244,-0.326458538431694,"LOC162137","uncharacterized LOC162137",TRUE
+"1553943_at",0.913160385122315,0.635677239704188,-0.480364106266628,-5.82791449277287,-0.184231025497753,"LOC171391","uncharacterized LOC171391",TRUE
+"216659_at",0.901781358899845,0.598960468758956,0.533556866080919,-5.80196811592215,0.480594375300141,"LOC1720","dihydrofolate reductase pseudogene",TRUE
+"233209_at",0.868838963163028,0.505237603928766,0.677282530015501,-5.71869811644267,0.268991888768967,"LOC200609","uncharacterized LOC200609",TRUE
+"241525_at",0.991689960875868,0.96079667092737,-0.0497128174121956,-5.93847984204388,-0.0197749962561935,"LOC200772","uncharacterized LOC200772",TRUE
+"1556898_at",0.96350209729653,0.833465969394364,-0.212751569396178,-5.91766144563092,-0.125410773375309,"LOC200830","uncharacterized LOC200830",TRUE
+"236079_at",0.969642324744141,0.854976816612784,0.184916368000671,-5.92304252361628,0.111124745522203,"LOC202025","uncharacterized LOC202025",TRUE
+"231375_at",0.730101539866086,0.212762266607127,-1.28296692488973,-5.1682790844793,-0.518245108959674,"LOC202181","SUMO interacting motifs containing 1 pseudogene",TRUE
+"220609_at",0.89037721023972,0.558897958032504,0.593438116040954,-5.7695955152504,0.469068893860735,"LOC202181","SUMO interacting motifs containing 1 pseudogene",TRUE
+"232309_at",0.931148651952691,0.695087354015494,0.397107822836787,-5.86316675649588,0.410134881983377,"LOC202181","SUMO interacting motifs containing 1 pseudogene",TRUE
+"1564385_at",0.93523910610914,0.712062013096494,-0.373860154984592,-5.87183432789929,-0.180136423523897,"LOC219688","uncharacterized LOC219688",TRUE
+"1564314_at",0.923124080520773,0.670545069793979,-0.431122056907655,-5.84955813485643,-0.36062573997213,"LOC219690","uncharacterized LOC219690",TRUE
+"216385_at",0.712055111306836,0.186172196336575,1.36429781599655,-5.07162249284463,0.343117693161494,"LOC220077","dedicator of cytokinesis 1 pseudogene",TRUE
+"216386_at",0.806216644294069,0.346735615885935,0.961381365507107,-5.49926894236769,0.710059860861907,"LOC220077","dedicator of cytokinesis 1 pseudogene",TRUE
+"1560278_at",0.716574546953368,0.192567532114967,1.34394465567406,-5.09627928859019,0.736580287391397,"LOC221122","uncharacterized LOC221122",TRUE
+"1560279_a_at",0.942671206410999,0.74279416221321,-0.332289032117019,-5.88604654820687,-0.107261158708149,"LOC221122","uncharacterized LOC221122",TRUE
+"232772_at",0.974982245454858,0.877736710818309,0.155626334884288,-5.92789390825662,0.0705841398079246,"LOC221272","uncharacterized LOC221272",TRUE
+"233043_at",0.946249611029538,0.756335466707377,-0.314163983120512,-5.89172483863748,-0.229975063688039,"LOC221814","uncharacterized LOC221814",TRUE
+"1569739_at",0.862639573412331,0.486263824693155,-0.708103986182484,-5.69837166720657,-0.390902114309098,"LOC221946","uncharacterized LOC221946",TRUE
+"1557871_at",0.988713664405312,0.94563611163449,0.0689649905063189,-5.93736719122956,0.0662443993426036,"LOC253573","uncharacterized LOC253573",TRUE
+"1556437_at",0.908667507590078,0.619955038172681,0.502960660685637,-5.8172168634064,0.339654666061262,"LOC253805","uncharacterized LOC253805",TRUE
+"1562581_at",0.570907288521428,0.0591007819484459,1.98974652186643,-4.17591406298534,1.31883056651047,"LOC254028","uncharacterized LOC254028",TRUE
+"210483_at",0.69385705848116,0.163237334401536,1.44218565040222,-4.97443715786797,0.903737253944217,"LOC254896///TNFRSF10C","uncharacterized LOC254896///TNF receptor superfamily member 10c",TRUE
+"210484_s_at",0.993083193605528,0.9671931898775,-0.0415961741866146,-5.9388407789453,-0.0283576095885216,"LOC254896///TNFRSF10C","uncharacterized LOC254896///TNF receptor superfamily member 10c",TRUE
+"1562501_at",0.598618215299661,0.0755266139114551,1.8646872022229,-4.37469790802545,1.32935258357589,"LOC255177","uncharacterized LOC255177",TRUE
+"1563074_at",0.858713522786197,0.47455014341079,0.727479140139428,-5.68515298789231,0.258226973420739,"LOC255654","uncharacterized LOC255654",TRUE
+"215302_at",0.974536463688956,0.875695226743448,0.158247480011598,-5.92749367231201,0.10114570219691,"LOC257152","uncharacterized LOC257152",TRUE
+"236076_at",0.976371465776674,0.887287395894621,0.143378319113807,-5.92967571466146,0.0507318757063677,"LOC257396","uncharacterized LOC257396",TRUE
+"1554840_at",0.943988850936011,0.749557737555442,0.323222173110145,-5.88892645388501,0.114677966360954,"LOC280665","anti-CNG alpha 1 cation channel translation product-like",TRUE
+"1557591_at",0.839519981963042,0.42785709974207,0.807687389142491,-5.62684252354659,0.684309585725126,"LOC283038","uncharacterized LOC283038",TRUE
+"1563853_at",0.863982129426672,0.490522400792656,0.701127203725149,-5.7030483475002,0.197794712491897,"LOC283045","uncharacterized LOC283045",TRUE
+"1563854_s_at",0.8913721384714,0.560794125635834,-0.5905557506394,-5.77123007824084,-0.306393945778005,"LOC283045","uncharacterized LOC283045",TRUE
+"233546_at",0.771177270679058,0.280392440444467,1.1064694494804,-5.36035289318103,0.579625723437157,"LOC283075","uncharacterized LOC283075",TRUE
+"234110_at",0.861659105448003,0.483044596839515,0.713401475294662,-5.69479118998067,0.52142448074787,"LOC283075","uncharacterized LOC283075",TRUE
+"1562400_at",0.946145819241213,0.756036664722544,-0.314562750915293,-5.89160330319845,-0.311827340235815,"LOC283112","uncharacterized LOC283112",TRUE
+"238112_at",0.895213601869362,0.573331754280673,0.571622195598558,-5.78177565164101,0.363479249941929,"LOC283177","uncharacterized LOC283177",TRUE
+"1557207_s_at",0.985032035638346,0.926208109311929,0.0936764679119847,-5.93541026874083,0.0278591163485693,"LOC283177","uncharacterized LOC283177",TRUE
+"1563867_at",0.883919021568462,0.542347168112614,0.618817384211873,-5.75487157176621,0.367066757882688,"LOC283194","uncharacterized LOC283194",TRUE
+"1561491_at",0.412444326023181,0.0165035930067555,2.59414684643221,-3.10527706099298,1.5662378087174,"LOC283214","uncharacterized LOC283214",TRUE
+"243285_at",0.952613441433926,0.782942910757122,-0.278854119604241,-5.90188044501624,-0.19748718763503,"LOC283335","uncharacterized LOC283335",TRUE
+"1561757_a_at",0.932091525948902,0.699762141570818,0.39068375474601,-5.86561339261456,0.238986429073249,"LOC283352","uncharacterized LOC283352",TRUE
+"1569454_a_at",0.940044918888428,0.731001018599939,-0.348166973301422,-5.88081342368544,-0.295539539474078,"LOC283352","uncharacterized LOC283352",TRUE
+"235151_at",0.976371465776674,0.886248409961054,-0.144709615856559,-5.92948909772576,-0.0646774976251541,"LOC283357","uncharacterized LOC283357",TRUE
+"1561233_at",0.697340169581683,0.167702061913072,1.42636607183884,-4.99453513767708,0.450806835910854,"LOC283387","uncharacterized LOC283387",TRUE
+"1561536_at",0.748184017928985,0.240670143138969,1.20565117669898,-5.25545427359741,0.572098296501414,"LOC283435","uncharacterized LOC283435",TRUE
+"1566734_at",0.738573426132641,0.225347634105985,1.24719807671248,-5.20918804953123,0.891951043845598,"LOC283454","uncharacterized LOC283454",TRUE
+"229552_at",0.705559553212919,0.177204023894175,1.39379101003545,-5.03534612988073,1.00071486687353,"LOC283454///HRK","uncharacterized LOC283454///harakiri, BCL2 interacting protein",TRUE
+"1566437_at",0.922908550456534,0.669839052723805,0.432108053517801,-5.84914726619289,0.308479262596644,"LOC283475","uncharacterized LOC283475",TRUE
+"1566438_at",0.977715419801783,0.892363143647894,0.136878314254684,-5.93056214325506,0.113808982971514,"LOC283475","uncharacterized LOC283475",TRUE
+"1561175_at",0.743323328391634,0.233429993583651,1.2250249580552,-5.23404828983721,0.704416560889673,"LOC283482","uncharacterized LOC283482",TRUE
+"1556940_at",0.822812833182588,0.387952300441041,0.880664860754064,-5.56883091749491,0.838809254248756,"LOC283484","uncharacterized LOC283484",TRUE
+"1556941_a_at",0.990810941805126,0.954346724522273,-0.0579007241816046,-5.93805073650665,-0.0535174665994314,"LOC283484","uncharacterized LOC283484",TRUE
+"1556477_a_at",0.784925710185113,0.309840928679783,-1.03937374009655,-5.42677757938848,-0.419456045516313,"LOC283485","uncharacterized LOC283485",TRUE
+"1556476_at",0.940227139261806,0.73214915090352,0.346617213098853,-5.88133483439405,0.199111721994194,"LOC283485","uncharacterized LOC283485",TRUE
+"1557345_at",0.290430545694223,0.00504468918484724,3.11260835221198,-2.07869057165081,1.57188924630157,"LOC283516","uncharacterized LOC283516",TRUE
+"1561442_at",0.957105919915331,0.805753208866394,-0.248870699115389,-5.90956137895128,-0.0736945335784247,"LOC283585","uncharacterized LOC283585",TRUE
+"1557113_at",0.0560907825756854,0.000107953115930898,-4.69778665426994,1.30478765849664,-2.25501972257577,"LOC283588","uncharacterized LOC283588",TRUE
+"1557328_at",0.689848451630875,0.158694050349901,-1.45864560228052,-4.95333388112283,-1.01479671647484,"LOC283665","uncharacterized LOC283665",TRUE
+"1566840_at",0.643515428391208,0.113908751847341,1.6458443798486,-4.69999311671759,1.10224875465538,"LOC283674","uncharacterized LOC283674",TRUE
+"1566839_at",0.997654912087849,0.988320726125903,-0.0148044041616465,-5.93957673150027,-0.0113709035563136,"LOC283674","uncharacterized LOC283674",TRUE
+"230783_at",0.94214388523134,0.739659403333669,0.336500916232301,-5.88468191427051,0.279961257975847,"LOC283713///OTUD7A","uncharacterized LOC283713///OTU deubiquitinase 7A",TRUE
+"1560723_at",0.705115396199375,0.176965586952864,-1.39459117247236,-5.03435298022627,-1.20082944033479,"LOC283731","uncharacterized LOC283731",TRUE
+"237687_at",0.425751189365875,0.0181969949300624,2.54995464397682,-3.18884636271295,2.15320442095327,"LOC283737","uncharacterized LOC283737",TRUE
+"1557628_s_at",0.732320150624823,0.21670279804897,-1.27159672167084,-5.1813904244005,-0.825517613043845,"LOC283745","uncharacterized LOC283745",TRUE
+"1557627_at",0.854040699678541,0.463120301624476,0.74665734454499,-5.67173504087295,0.420594433336591,"LOC283745","uncharacterized LOC283745",TRUE
+"229007_at",0.686025661550069,0.154294605579903,1.47495179863115,-4.93223622895068,1.67163757759245,"LOC283788","FSHD region gene 1 pseudogene",TRUE
+"1560463_at",0.740476003158683,0.229177312765651,1.23661763884609,-5.22109863960644,0.815430393536569,"LOC283788","FSHD region gene 1 pseudogene",TRUE
+"1558107_at",0.815195559141692,0.366082793563969,0.92273942693872,-5.53327133534005,0.975056485144226,"LOC283788","FSHD region gene 1 pseudogene",TRUE
+"228247_at",0.920800738105699,0.663244622674863,-0.441338802211126,-5.84525608116695,-0.140268424796796,"LOC283788","FSHD region gene 1 pseudogene",TRUE
+"1558109_x_at",0.965992617204023,0.840916691834134,0.20309194385574,-5.91961385495952,0.164947383742533,"LOC283788","FSHD region gene 1 pseudogene",TRUE
+"229187_at",0.993354935415366,0.96879131634483,0.0395687553051933,-5.93892092140423,0.0413886591824371,"LOC283788","FSHD region gene 1 pseudogene",TRUE
+"1560707_at",0.722495630405516,0.199140542299243,1.32357198703256,-5.12064823340066,0.441905522272384,"LOC283856","uncharacterized LOC283856",TRUE
+"1554520_at",0.68747436517451,0.156254681886792,-1.46764099513536,-4.94171874557235,-1.24629887081144,"LOC283861","uncharacterized LOC283861",TRUE
+"1564373_a_at",0.931121627074226,0.69495133784237,0.397294989065783,-5.86309488411856,0.230414004136314,"LOC283887","uncharacterized LOC283887",TRUE
+"1556709_a_at",0.951343155145488,0.777511840483821,-0.286030686914872,-5.89991348924967,-0.199066057497173,"LOC283887","uncharacterized LOC283887",TRUE
+"1558999_x_at",0.687659256779784,0.156737259405389,-1.46585246648773,-4.9440327597201,-1.11583668210931,"LOC283922///PDPR","pyruvate dehydrogenase phosphatase regulatory subunit pseudogene///pyruvate dehydrogenase phosphatase regulatory subunit",TRUE
+"238931_at",0.501591596209182,0.0322066168414832,2.2855207639506,-3.67271633698497,0.811225767422435,"LOC284009///METTL16","uncharacterized LOC284009///methyltransferase like 16",TRUE
+"220797_at",0.597654932724127,0.0739629432602655,1.87550285312162,-4.35786148672997,0.649363445156169,"LOC284009///METTL16","uncharacterized LOC284009///methyltransferase like 16",TRUE
+"226744_at",0.645072069975909,0.11553199171527,1.63806869336741,-4.71099004298828,0.598705009029349,"LOC284009///METTL16","uncharacterized LOC284009///methyltransferase like 16",TRUE
+"1557399_at",0.769847953580141,0.278458996713059,1.11104899483439,-5.35568426669637,0.625233705857077,"LOC284009///METTL16","uncharacterized LOC284009///methyltransferase like 16",TRUE
+"1558723_at",0.749162452855464,0.242250567181494,-1.20148073663688,-5.26002345523483,-0.512831339481106,"LOC284014","uncharacterized LOC284014",TRUE
+"238096_at",0.914562242038395,0.640052563955011,-0.474121080128388,-5.83078530425369,-0.185499156364432,"LOC284023","uncharacterized LOC284023",TRUE
+"1557608_a_at",0.597654932724127,0.0737195107015614,1.87720455884591,-4.35520623692172,0.827644766402955,"LOC284080","uncharacterized LOC284080",TRUE
+"1557607_at",0.835952408568777,0.416429911464447,0.828127102219679,-5.61106700348631,0.540908028714317,"LOC284080","uncharacterized LOC284080",TRUE
+"1556425_a_at",0.587626678796111,0.0666331994306363,1.9290352726461,-4.27352754414298,1.10072425695801,"LOC284219","uncharacterized LOC284219",TRUE
+"233474_at",0.980570785147084,0.909240382242487,0.115307051637594,-5.93320970177997,0.0889771980687923,"LOC284240","uncharacterized LOC284240",TRUE
+"1560250_s_at",0.97928472590149,0.89952368638731,0.127718710640457,-5.93174159508552,0.0525341743005665,"LOC284242","uncharacterized LOC284242",TRUE
+"1562585_at",0.7994347047598,0.334520991210797,0.986537223976635,-5.47644848081605,0.801735167569348,"LOC284263","uncharacterized LOC284263",TRUE
+"1561455_at",0.457531863501901,0.0227866349211829,2.44710218719741,-3.38046859989476,1.96756937152038,"LOC284294","uncharacterized LOC284294",TRUE
+"1569006_at",0.98529096111871,0.92711629715997,0.0925200871475797,-5.93551509651239,0.0609670887425073,"LOC284379","solute carrier family 7 member 3 pseudogene",TRUE
+"1563872_at",0.941306621461417,0.73718483343885,0.339830151512522,-5.88359122498543,0.107853965954697,"LOC284395","uncharacterized LOC284395",TRUE
+"1556597_a_at",0.843424227955276,0.437994014352375,0.78983821757655,-5.64031575028225,0.554416302662101,"LOC284513","uncharacterized LOC284513",TRUE
+"233737_s_at",0.362897608186913,0.0105279161067953,2.7942925548082,-2.71832633890912,2.30426836595068,"LOC284561","uncharacterized LOC284561",TRUE
+"232689_at",0.717937808890208,0.19376538037319,1.34019181016301,-5.10079177583452,0.757506144465502,"LOC284561","uncharacterized LOC284561",TRUE
+"233769_at",0.931370027472813,0.695850902422377,-0.396057403172056,-5.86356950178049,-0.288661159729299,"LOC284561","uncharacterized LOC284561",TRUE
+"1558189_a_at",0.767727587789514,0.269900757253873,-1.13160292944219,-5.33452029307937,-1.01196453333703,"LOC284570///GPR37L1","uncharacterized LOC284570///G protein-coupled receptor 37 like 1",TRUE
+"1557474_at",0.967098812766994,0.84655199080385,0.19579911569462,-5.92102803041533,0.127228286447577,"LOC284578","uncharacterized LOC284578",TRUE
+"1559083_x_at",0.870857065562116,0.510711677186716,0.668512646194707,-5.72432372436973,0.577092327178009,"LOC284600","uncharacterized LOC284600",TRUE
+"1562716_at",0.776987722157386,0.296100890331436,1.07008361552747,-5.39683595461979,0.563747236037542,"LOC284632","uncharacterized LOC284632",TRUE
+"231427_at",0.958890985195826,0.813886674896803,0.238237097968303,-5.91207702760063,0.109076306006542,"LOC284648","uncharacterized LOC284648",TRUE
+"1561384_a_at",0.431769566611896,0.0191971298716298,2.5256296714826,-3.23453548160018,1.6280588063297,"LOC284661","uncharacterized LOC284661",TRUE
+"1561383_at",0.792365216719119,0.323554564763988,-1.0096671756407,-5.4549930379278,-0.822068585296436,"LOC284661","uncharacterized LOC284661",TRUE
+"1560935_s_at",0.40129202983775,0.0143795964711015,2.65602586666344,-2.98708092614987,1.57793501607286,"LOC284669","uncharacterized LOC284669",TRUE
+"1560934_at",0.643688366500038,0.114547986799797,1.64277124813871,-4.70434412795521,0.868200297346899,"LOC284669","uncharacterized LOC284669",TRUE
+"1557483_at",0.886023097762234,0.548287197585177,0.60966250911394,-5.76025142188462,0.307610742301461,"LOC284788","uncharacterized LOC284788",TRUE
+"1561978_at",0.682125064335234,0.149683353177835,1.4924534581969,-4.90938125447388,0.8276904854811,"LOC284798","uncharacterized LOC284798",TRUE
+"237351_at",0.835952408568777,0.416955395183747,0.827179503469974,-5.61180652950287,0.56750277018928,"LOC284825","uncharacterized LOC284825",TRUE
+"1564109_at",0.964685626382167,0.836480476631275,-0.208840914875249,-5.91846275131099,-0.0705165932972802,"LOC284865","uncharacterized LOC284865",TRUE
+"1562030_at",0.504806452553042,0.0327951078092072,2.27693992724231,-3.68791539090803,1.76154309508637,"LOC284898","uncharacterized LOC284898",TRUE
+"224117_at",0.817857130700434,0.370571155110221,0.913971518907537,-5.54080794299999,0.320563374503408,"LOC284912///MB","uncharacterized LOC284912///myoglobin",TRUE
+"1556064_at",0.737123149977386,0.222953071915749,-1.25388354096874,-5.20161715223015,-0.58110261411937,"LOC284926","uncharacterized LOC284926",TRUE
+"1564446_at",0.776074974591224,0.293561179751125,1.07587071786382,-5.39110618896945,0.567595133170925,"LOC284930","uncharacterized LOC284930",TRUE
+"1563009_at",0.969642324744141,0.855026790826314,-0.184851883393415,-5.92305411822058,-0.128288966858346,"LOC284930","uncharacterized LOC284930",TRUE
+"240754_at",0.94895689004559,0.768775087921226,-0.297607800724085,-5.89663593860382,-0.112489310031897,"LOC284933","uncharacterized LOC284933",TRUE
+"1556001_at",0.624331975868069,0.0956461532422702,-1.74048435868702,-4.56299650564814,-0.645435582979354,"LOC284939///MAPK8IP2","uncharacterized LOC284939///mitogen-activated protein kinase 8 interacting protein 2",TRUE
+"1563680_at",0.969882914559333,0.856148638629483,0.183404509078238,-5.9233133016479,0.163132061411725,"LOC284950","uncharacterized LOC284950",TRUE
+"240428_at",0.979588787486838,0.902942106936114,0.123349937207545,-5.93227543052083,0.100245956163231,"LOC285000","uncharacterized LOC285000",TRUE
+"1559605_a_at",0.91676531736797,0.6482078174078,0.46253517865203,-5.83601558137183,0.235092368960742,"LOC285043","uncharacterized LOC285043",TRUE
+"238196_at",0.938335759577472,0.726144020548375,0.354732675601597,-5.87857892158368,0.135353530656126,"LOC285095","uncharacterized LOC285095",TRUE
+"1556474_a_at",0.459111781250135,0.0229576883390557,-2.44365447613597,-3.38681950063966,-2.14196551807765,"LOC285097","uncharacterized FLJ38379",TRUE
+"1556473_at",0.649719797552144,0.120259064494334,-1.61593593059525,-4.74207230631083,-2.37089167520252,"LOC285097","uncharacterized FLJ38379",TRUE
+"242852_at",0.631458035234765,0.102765680795957,-1.70190184344226,-4.61954248231415,-1.58868757655969,"LOC285147","uncharacterized LOC285147",TRUE
+"236166_at",0.962555471240652,0.829401293014684,0.218029975515699,-5.91655641370342,0.141274191613442,"LOC285147","uncharacterized LOC285147",TRUE
+"230057_at",0.930827859648584,0.693633336974505,0.399109384986116,-5.86239642196939,0.125051906706047,"LOC285178","uncharacterized LOC285178",TRUE
+"1561334_at",0.946579549170519,0.758060029995068,-0.311863471100676,-5.89242300101261,-0.216296475389716,"LOC285181","uncharacterized LOC285181",TRUE
+"1562632_at",0.899331416659389,0.589959645901814,-0.546831918158204,-5.79507953402522,-0.281000385095434,"LOC285191","uncharacterized LOC285191",TRUE
+"1563691_at",0.808328926947236,0.351327694428927,0.952080475146161,-5.50756995810538,0.487984695361184,"LOC285300","uncharacterized LOC285300",TRUE
+"1563685_at",0.775014733699535,0.291465074610514,1.08067409836345,-5.38632942886113,0.508807454481431,"LOC285422","uncharacterized LOC285422",TRUE
+"1569781_at",0.888603757551911,0.554779609931771,0.599715978382195,-5.7660087820813,0.397421723749097,"LOC285423","uncharacterized LOC285423",TRUE
+"1558451_at",0.73957587762701,0.227731924824972,1.24059494359626,-5.216631558883,1.08811420229733,"LOC285500","uncharacterized LOC285500",TRUE
+"236523_at",0.73957587762701,0.227928464047305,1.24005299570081,-5.21724097045625,1.1865001249949,"LOC285556","uncharacterized LOC285556",TRUE
+"1562739_at",0.71789173952175,0.193534024888309,-1.34091522259395,-5.09992275551089,-0.783486669942916,"LOC285593","uncharacterized LOC285593",TRUE
+"1560260_at",0.875527130784629,0.522962323496377,-0.64907399488348,-5.73654246283745,-0.420659038344833,"LOC285593","uncharacterized LOC285593",TRUE
+"1561401_at",0.687545925823023,0.156366746793471,1.46722526154244,-4.94225682920906,0.976050069788584,"LOC285627","uncharacterized LOC285627",TRUE
+"1563489_at",0.79782885150643,0.331563277555295,0.992723193473921,-5.47075458960611,0.304654602257636,"LOC285638","uncharacterized LOC285638",TRUE
+"1561650_s_at",0.769847953580141,0.278477638934885,-1.11100472877807,-5.35572947569235,-0.852217201590667,"LOC285692","uncharacterized LOC285692",TRUE
+"1568739_at",0.903615659612912,0.604977388310169,-0.524736632835895,-5.80645396389542,-0.397062732742278,"LOC285692","uncharacterized LOC285692",TRUE
+"1553335_x_at",0.821187434813103,0.382332170776946,0.891325247732405,-5.55996640862915,0.605311140912105,"LOC285696","uncharacterized LOC285696",TRUE
+"1564253_at",0.770807031642694,0.279271259611224,1.10912226722512,-5.35765055794127,0.490850212588046,"LOC285766","uncharacterized LOC285766",TRUE
+"230179_at",0.528056136690037,0.0405679553539918,2.17511346037385,-3.86564873692705,1.32303740861387,"LOC285812","uncharacterized LOC285812",TRUE
+"1562388_at",0.528328646587879,0.0409575020959889,2.17049173782981,-3.87359768529034,2.0602960255062,"LOC285819","uncharacterized LOC285819",TRUE
+"1570131_at",0.709158363400091,0.181923277641512,1.37812723831722,-5.05469264934581,0.929248917291424,"LOC285847","uncharacterized LOC285847",TRUE
+"1557723_at",0.887083096014278,0.551334731893918,0.604985951819234,-5.76296974425714,0.334925635395064,"LOC285847","uncharacterized LOC285847",TRUE
+"1557724_a_at",0.973066963106626,0.869504518510057,0.166203008806514,-5.92623807078976,0.0457033951355736,"LOC285847","uncharacterized LOC285847",TRUE
+"1564125_at",0.924696623416105,0.674355328297929,-0.425808255525248,-5.8517565411984,-0.263238166721185,"LOC285857","uncharacterized LOC285857",TRUE
+"1562424_at",0.955730092376044,0.797661466618036,0.259478933413904,-5.90694295604986,0.173588092634431,"LOC285889","uncharacterized LOC285889",TRUE
+"243661_at",0.864894115958506,0.493349076649507,-0.696515502402266,-5.7061154229803,-0.359822438397515,"LOC285902///ZNF273","uncharacterized LOC285902///zinc finger protein 273",TRUE
+"1555368_x_at",0.709135917979769,0.181734215407803,-1.37874851925991,-5.05392875186028,-0.577859835341196,"LOC285902///ZNF479///ZNF273","uncharacterized LOC285902///zinc finger protein 479///zinc finger protein 273",TRUE
+"1555367_at",0.774230543658252,0.287552665098567,1.08970651991613,-5.37729565367744,0.678224162461641,"LOC285902///ZNF479///ZNF273","uncharacterized LOC285902///zinc finger protein 479///zinc finger protein 273",TRUE
+"243601_at",0.881820718005617,0.538688833678786,0.624482252163965,-5.75150392200986,0.497376457694311,"LOC285957","uncharacterized LOC285957",TRUE
+"241370_at",0.971867994936839,0.86536805446191,-0.17152477191223,-5.92536387059328,-0.117153680018829,"LOC286052","uncharacterized LOC286052",TRUE
+"1562247_at",0.959741600760902,0.818230783177145,-0.232569223186339,-5.9133732783173,-0.170310820019932,"LOC286058","uncharacterized LOC286058",TRUE
+"234147_at",0.784552021081681,0.30810991173436,-1.04318878996353,-5.42310058509139,-0.857625482412787,"LOC286059","tumor necrosis factor receptor superfamily member 10d, decoy with truncated death domain pseudogene",TRUE
+"234141_s_at",0.869784729509912,0.507480726569641,0.673682461418722,-5.72101593942424,0.261573884246653,"LOC286059","tumor necrosis factor receptor superfamily member 10d, decoy with truncated death domain pseudogene",TRUE
+"1561988_at",0.992583835836326,0.96537471169129,-0.0439033540158361,-5.93874470798348,-0.0310767066335638,"LOC286068","uncharacterized LOC286068",TRUE
+"231032_at",0.975196332002567,0.879303315390055,0.153615664707376,-5.92819640753847,0.137079430191889,"LOC286071","uncharacterized LOC286071",TRUE
+"1561257_at",0.675622576285316,0.141958297342953,1.52278502696078,-4.86926038696118,1.00400326143907,"LOC286083","uncharacterized LOC286083",TRUE
+"1556842_at",0.523369751179323,0.0388620427234537,2.19583881966768,-3.82987467581842,1.54622399181124,"LOC286087","uncharacterized LOC286087",TRUE
+"1562724_at",0.660093442228076,0.128084180972766,1.58084686436758,-4.79067736149272,1.0156771848525,"LOC286114","uncharacterized LOC286114",TRUE
+"244255_at",0.862800800218883,0.486571402846423,0.707598906046738,-5.69871171441246,0.384901454429765,"LOC286114","uncharacterized LOC286114",TRUE
+"1561671_at",0.977063818674184,0.890451913692513,0.13932511198246,-5.93023328156252,0.100096886418312,"LOC286121","uncharacterized LOC286121",TRUE
+"1559030_a_at",0.414637020271776,0.0167586669298721,2.5872258164355,-3.11841227651225,1.94310639898771,"LOC286154","uncharacterized LOC286154",TRUE
+"1559029_at",0.695812999227098,0.165905348764795,-1.43269104587849,-4.98652132495651,-0.954521904312351,"LOC286154","uncharacterized LOC286154",TRUE
+"228615_at",0.787983178144695,0.314062761751675,1.03013172916259,-5.43563482607197,0.447488945976278,"LOC286161","uncharacterized LOC286161",TRUE
+"1562365_at",0.576675680499645,0.061308294468092,1.97127704906183,-4.20582748423301,1.77636775220296,"LOC286177","uncharacterized LOC286177",TRUE
+"1556573_s_at",0.555307820043702,0.0514581657114805,2.05881338060386,-4.06240800401451,0.77861120194814,"LOC286178","uncharacterized LOC286178",TRUE
+"230661_at",0.937271400689562,0.721984488529134,0.360368190870944,-5.87662810163668,0.329354448379712,"LOC286191","uncharacterized LOC286191",TRUE
+"1564709_at",0.779854829728531,0.301236850235645,-1.0584881254372,-5.40823328280813,-0.62957809396728,"LOC286238","uncharacterized LOC286238",TRUE
+"232182_at",0.67606695078322,0.142632506214622,1.52008470799834,-4.87285835552469,0.676703941744151,"LOC286272","uncharacterized LOC286272",TRUE
+"238536_at",0.846552177460323,0.444869102607121,0.777876783566057,-5.64918604332155,0.532584077371709,"LOC286272","uncharacterized LOC286272",TRUE
+"1563607_x_at",0.752235383514782,0.245512781957533,1.19293660312777,-5.26934151295709,0.723844112252931,"LOC286359","uncharacterized LOC286359",TRUE
+"1563606_a_at",0.990441250488535,0.951874274314962,-0.0610404291728204,-5.93786887860936,-0.0243938970914614,"LOC286359","uncharacterized LOC286359",TRUE
+"240545_at",0.803135302652907,0.341124502748571,0.972860755556738,-5.48892196023309,0.698860597162599,"LOC286382","uncharacterized LOC286382",TRUE
+"239762_at",0.917376120957266,0.650242234871109,-0.459654998013242,-5.83729612663776,-0.366310335407572,"LOC286437","uncharacterized LOC286437",TRUE
+"230930_at",0.659951950356122,0.127746238546251,1.58232485217002,-4.78864684763598,1.54010121964487,"LOC338620","uncharacterized LOC338620",TRUE
+"1564786_at",0.855289633438347,0.467761693993113,-0.738836118690353,-5.67724712219929,-0.542896043275542,"LOC338667","V-set and immunoglobulin domain-containing protein 10-like",TRUE
+"1563042_at",0.807944276806637,0.349513052355925,0.955745970957891,-5.50430733170581,0.46552484653166,"LOC338694","uncharacterized LOC338694",TRUE
+"1563878_a_at",0.759156678237018,0.256755020984615,1.16412716309618,-5.30033259217262,0.663703927186562,"LOC338963","epididymal protein pseudogene",TRUE
+"1560455_at",0.729229845942426,0.211324101615631,1.28715713540327,-5.16342214905319,1.00448196568083,"LOC339166///WSCD1","uncharacterized LOC339166///WSC domain containing 1",TRUE
+"213155_at",0.871451481476429,0.51229855558356,0.66598019191901,-5.72593515062114,0.395929793645158,"LOC339166///WSCD1","uncharacterized LOC339166///WSC domain containing 1",TRUE
+"213157_s_at",0.896159990898752,0.57934196303227,-0.562620656477933,-5.78667254571222,-0.321140111207847,"LOC339166///WSCD1","uncharacterized LOC339166///WSC domain containing 1",TRUE
+"1562754_at",0.773427028595643,0.2848300803668,1.09604444803555,-5.37091678409991,1.00714826288928,"LOC339260","uncharacterized LOC339260",TRUE
+"1561277_at",0.854163696308241,0.463789664687806,0.745526532088663,-5.67253539355813,0.445471101774608,"LOC339298","uncharacterized LOC339298",TRUE
+"1569835_at",0.856857560656867,0.47116561494649,0.733129346850566,-5.68123427558982,0.376557924311452,"LOC339352","cytosolic thiouridylase subunit 1 homolog (S. pombe) pseudogene",TRUE
+"1562908_at",0.525405708458677,0.0393802028946256,2.18945781066212,-3.84091120427861,0.85691719585462,"LOC339468","uncharacterized LOC339468",TRUE
+"1562496_at",0.296964617886988,0.00540972582378492,3.082782868306,-2.13969683710995,2.01474938950751,"LOC339539","uncharacterized LOC339539",TRUE
+"1562829_at",0.925511384407886,0.677765769386746,0.421062593437166,-5.85369724911333,0.291955789357808,"LOC339568","uncharacterized LOC339568",TRUE
+"1564049_at",0.940567117317801,0.733839736424737,0.344336817235774,-5.88209788358496,0.269230558765418,"LOC339593","uncharacterized LOC339593",TRUE
+"1561290_at",0.47984873377716,0.0269913157296118,2.36856536522406,-3.52391824503154,1.98839397287368,"LOC339622","uncharacterized LOC339622",TRUE
+"1562841_at",0.991215113882097,0.958769265803845,0.0522861114809143,-5.93835201704141,0.0330956634912773,"LOC339666","uncharacterized LOC339666",TRUE
+"1562264_at",0.768852835478002,0.27310860873436,1.12384374502234,-5.34255009437509,0.479196269840742,"LOC339685","uncharacterized LOC339685",TRUE
+"227941_at",0.920242295615997,0.660504223262159,0.445186200080903,-5.84361039337383,0.547210416374005,"LOC339803","uncharacterized LOC339803",TRUE
+"227940_at",0.936992192746977,0.718343924887238,-0.365310356651257,-5.87489230609984,-0.598386329698377,"LOC339803","uncharacterized LOC339803",TRUE
+"1562776_at",0.870128192701327,0.50837448537085,0.672250525764014,-5.72193457246831,0.317918549311057,"LOC339807","uncharacterized LOC339807",TRUE
+"1557534_at",0.936992192746977,0.717876605962593,-0.365945424237572,-5.87466756418746,-0.312492230418971,"LOC339862","uncharacterized LOC339862",TRUE
+"1561348_at",0.615821255316333,0.0868421352037077,1.791751850399,-4.48641355101038,0.71703545796605,"LOC339874","uncharacterized LOC339874",TRUE
+"1562638_at",0.823368330423456,0.390208169521421,0.876414204341578,-5.57233790944739,0.738022823937186,"LOC339874","uncharacterized LOC339874",TRUE
+"1561323_at",0.928246500493356,0.684839701217761,-0.411250261602114,-5.85764210924416,-0.286985946931129,"LOC339975","uncharacterized LOC339975",TRUE
+"1562540_at",0.900751557533293,0.596372005605326,0.537364483325799,-5.80000913366714,0.461658869499825,"LOC339978","uncharacterized LOC339978",TRUE
+"1562697_at",0.553930058946379,0.0506690466561707,2.06645743298494,-4.04968908731026,0.764717120881233,"LOC339988","uncharacterized LOC339988",TRUE
+"1562698_x_at",0.91269009113888,0.633696115978752,-0.483197282834171,-5.82659956076938,-0.322497243726903,"LOC339988","uncharacterized LOC339988",TRUE
+"1560823_at",0.952041062962677,0.78059024346416,-0.281961054417936,-5.90103498330298,-0.342605794928762,"LOC340017","uncharacterized LOC340017",TRUE
+"1562617_at",0.766390367856479,0.266828312167136,1.13909823429683,-5.3267172731075,0.431257703617622,"LOC340074","uncharacterized LOC340074",TRUE
+"232455_x_at",0.823074246722209,0.3898247672997,0.877135506645554,-5.57174391041122,0.293569121784783,"LOC340085","uncharacterized LOC340085",TRUE
+"1562492_at",0.994050962712312,0.97190137618791,-0.0356237433340903,-5.93906539165598,-0.0277364602696211,"LOC340090","uncharacterized LOC340090",TRUE
+"1557008_at",0.826617572584789,0.394916828778917,0.867592962538906,-5.57956555980031,0.351878763548939,"LOC340107","uncharacterized LOC340107",TRUE
+"1557009_a_at",0.929234395612144,0.689013966669793,-0.405479361175699,-5.85991945256684,-0.345648352874712,"LOC340107","uncharacterized LOC340107",TRUE
+"1563589_at",0.843475287501313,0.438683841214747,0.78863287056319,-5.64121538138355,0.687405038940993,"LOC340184","uncharacterized LOC340184",TRUE
+"1561254_at",0.418769817352331,0.0171545131324172,2.57667827996075,-3.13839661730049,1.71087082088923,"LOC340340","uncharacterized LOC340340",TRUE
+"1562924_at",0.457302841869409,0.0226915886601135,2.44902830973471,-3.37691846187373,0.936014137499208,"LOC340357","uncharacterized LOC340357",TRUE
+"1563059_at",0.975265330414469,0.88035039060445,0.152272150241596,-5.92839634784845,0.102339790491484,"LOC340581","uncharacterized LOC340581",TRUE
+"240573_at",0.552420073963858,0.049651369361884,2.07647436532074,-4.03297554431418,1.82192719440213,"LOC374443","C-type lectin domain family 2 member D pseudogene",TRUE
+"238790_at",0.903678874758741,0.6051662417227,-0.524460476198195,-5.80659323803192,-0.266291670696087,"LOC374443","C-type lectin domain family 2 member D pseudogene",TRUE
+"240572_s_at",0.961395512423249,0.824683691465102,0.22416423741712,-5.91523834447716,0.144991262247007,"LOC374443","C-type lectin domain family 2 member D pseudogene",TRUE
+"1556405_s_at",0.859696489664632,0.477923636092483,0.721870849621641,-5.6890141379923,0.479660974280155,"LOC374890","uncharacterized LOC374890",TRUE
+"1556244_s_at",0.0244427643695834,2.05645571285018e-05,5.38105266653357,2.75361530357608,3.43679363719896,"LOC375196","uncharacterized LOC375196",TRUE
+"1563117_at",0.822850703882235,0.38824104150094,-0.880119899923544,-5.56928141568777,-0.323674095771946,"LOC388456","uncharacterized LOC388456",TRUE
+"235284_s_at",0.701911663048518,0.173490107532554,1.40635308402455,-5.01969997905005,0.709921364805764,"LOC388692","uncharacterized LOC388692",TRUE
+"232346_at",0.80818658267298,0.349967470481487,0.954826858018906,-5.5051265043705,0.490137293752829,"LOC388692","uncharacterized LOC388692",TRUE
+"236674_at",0.627087721741888,0.0979484068344897,1.72774737576672,-4.58176810223618,0.615551498878685,"LOC388780","uncharacterized LOC388780",TRUE
+"1554940_a_at",0.961212424803935,0.823002491303392,-0.226352404482059,-5.91475936650598,-0.142961604819434,"LOC388882","uncharacterized LOC388882",TRUE
+"237111_at",0.843475287501313,0.438276213200222,-0.78934498549981,-5.64068403873602,-0.273179384789181,"LOC388942","uncharacterized LOC388942",TRUE
+"1554809_at",0.982844899319041,0.91658950932236,-0.105932031128858,-5.93421933304993,-0.0599172267775154,"LOC389199","uncharacterized LOC389199",TRUE
+"1560841_at",0.932830928398943,0.703565833706876,0.385469073932563,-5.86757051328268,0.12109469914393,"LOC389247","uncharacterized LOC389247",TRUE
+"237450_at",0.977874971442423,0.893093701835826,0.135943264785643,-5.93068628252846,0.102841723791023,"LOC389332","uncharacterized LOC389332",TRUE
+"244886_at",0.808265722812663,0.350950676901191,0.952840975860264,-5.50689398669547,0.274811400662179,"LOC389641","uncharacterized LOC389641",TRUE
+"230815_at",0.792436690618566,0.323829388279787,-1.00908093450065,-5.45554240727832,-0.523073394279305,"LOC389765","kinesin family member 27 pseudogene",TRUE
+"227835_at",0.750010222174363,0.242774227929435,-1.20010340823416,-5.26152945045569,-1.15306300364092,"LOC389831","uncharacterized LOC389831",TRUE
+"236181_at",0.955835103965794,0.79893304529011,-0.257809915387473,-5.90736211721781,-0.21321370585468,"LOC389831","uncharacterized LOC389831",TRUE
+"241624_at",0.536186589417525,0.0430835822816895,2.14594673894075,-3.91563614879238,1.25138759229928,"LOC389834","ankyrin repeat domain 57 pseudogene",TRUE
+"241625_at",0.544577979658206,0.0466054516100578,2.10759551117198,-3.98071655843494,1.64327533191,"LOC389834","ankyrin repeat domain 57 pseudogene",TRUE
+"242577_at",0.695005304830231,0.164633592397725,1.43720137050966,-4.98078898195447,1.25233191782832,"LOC389834","ankyrin repeat domain 57 pseudogene",TRUE
+"244631_at",0.760237493549547,0.258334647739266,1.16015485032747,-5.30455369190007,0.679300919903623,"LOC389834","ankyrin repeat domain 57 pseudogene",TRUE
+"240312_at",0.76912869907427,0.27496277541519,-1.11938921616211,-5.34713790442533,-0.900482738102953,"LOC389895","chromosome 16 open reading frame 72-like",TRUE
+"222196_at",0.87579870142401,0.523400725762808,0.648383045542595,-5.73697041251873,0.735985734554578,"LOC389906","zinc finger protein 839 pseudogene",TRUE
+"1558046_x_at",0.901154557823402,0.597575586576186,-0.535593024880946,-5.80092221743281,-0.405465053748805,"LOC389906","zinc finger protein 839 pseudogene",TRUE
+"1556102_x_at",0.92265243752289,0.66944383667992,0.4326601872968,-5.84891678724133,0.285429677875492,"LOC389906","zinc finger protein 839 pseudogene",TRUE
+"222031_at",0.986342822130003,0.935034494974814,-0.082443271769369,-5.93637350689533,-0.0457328927089913,"LOC389906","zinc finger protein 839 pseudogene",TRUE
+"1569629_x_at",0.991689960875868,0.961039760755536,-0.0494042978807587,-5.93849473446002,-0.0275813224590067,"LOC389906","zinc finger protein 839 pseudogene",TRUE
+"1558045_a_at",0.99783553534859,0.989233878193745,-0.0136468333443357,-5.93959277243765,-0.011654944702677,"LOC389906","zinc finger protein 839 pseudogene",TRUE
+"237163_x_at",0.730101539866086,0.212888636064409,1.28259978337253,-5.16870400116806,0.416824765674265,"LOC390705","protein phosphatase 2 regulatory subunit B'', beta pseudogene",TRUE
+"239993_at",0.869971289491322,0.507819341195382,0.673139783682734,-5.72136430491128,0.481052311076452,"LOC390705","protein phosphatase 2 regulatory subunit B'', beta pseudogene",TRUE
+"1559756_at",0.901958015780129,0.600299044101017,0.531590958221847,-5.80297425149702,0.511089657976206,"LOC399716","uncharacterized LOC399716",TRUE
+"244252_at",0.849935057946582,0.452091812094552,-0.765431302724336,-5.65827971516117,-0.513857602783034,"LOC399884","uncharacterized LOC399884",TRUE
+"237478_at",0.740476003158683,0.229604939093224,1.23544458956664,-5.22241378163947,0.328594289102718,"LOC399900","uncharacterized LOC399900",TRUE
+"1560058_at",0.843475287501313,0.438374172849855,0.789173815550717,-5.64081179795637,0.227633660685931,"LOC399900","uncharacterized LOC399900",TRUE
+"226582_at",0.865733085695438,0.495819866443952,0.69249680182673,-5.70877236584628,0.826189689948674,"LOC400043","uncharacterized LOC400043",TRUE
+"244889_at",0.980084804016714,0.906500019005491,0.118805500951783,-5.9328110453811,0.0867670453805989,"LOC400499///LOC388210","vitellogenin///uncharacterized LOC388210",TRUE
+"1562568_at",0.862800800218883,0.486786249638682,-0.707246211321101,-5.69894903046224,-0.598524307356088,"LOC400541","uncharacterized LOC400541",TRUE
+"1562659_at",0.762080380772594,0.261442006440815,1.15239292453231,-5.31276519698582,0.587901750659425,"LOC400548","uncharacterized LOC400548",TRUE
+"1560513_at",0.982844899319041,0.916606718492628,-0.105910089746511,-5.93422159574882,-0.0444668489994946,"LOC400568","uncharacterized LOC400568",TRUE
+"1560994_x_at",0.754655288916613,0.248114924070691,1.18618209727826,-5.27666685300053,1.21937556930733,"LOC400590","uncharacterized LOC400590",TRUE
+"1560992_at",0.78578093265889,0.311264639079524,1.03624723555467,-5.42978189992094,1.17934243102177,"LOC400590","uncharacterized LOC400590",TRUE
+"1562000_at",0.557072414954305,0.0521355185589803,2.05233513448518,-4.07316302662327,0.883258270055367,"LOC400620","uncharacterized LOC400620",TRUE
+"1557731_at",0.916057757219214,0.645986830233083,-0.465684033468478,-5.83460661690066,-0.238377818570672,"LOC400620","uncharacterized LOC400620",TRUE
+"1556435_at",0.622434989367596,0.093049154722834,1.75517073123076,-4.54122526114732,1.1564498390212,"LOC400622","uncharacterized LOC400622",TRUE
+"1565905_at",0.981944022360435,0.913521214268552,-0.109844914254684,-5.93380833146288,-0.04668009160015,"LOC400627","uncharacterized LOC400627",TRUE
+"1561514_at",0.868397087637799,0.504305468630675,0.678781192583318,-5.71772975263115,0.592497982509949,"LOC400655","uncharacterized LOC400655",TRUE
+"1569264_at",0.978688939278571,0.896706399874898,0.131321139952607,-5.93128744833779,0.0553250424865928,"LOC400655","uncharacterized LOC400655",TRUE
+"232965_at",0.830635993561085,0.403635477861002,-0.851436907374598,-5.59262653847922,-0.307967977722563,"LOC400684","uncharacterized LOC400684",TRUE
+"1555798_at",0.881970070870254,0.539138705365363,-0.623784526331168,-5.75192030212143,-0.652013877216608,"LOC400692","uncharacterized LOC400692",TRUE
+"1564401_at",0.707898177720919,0.179914614468543,1.3847543091702,-5.04652958943795,1.19573527111229,"LOC400748","uncharacterized LOC400748",TRUE
+"1556255_a_at",0.171966540888944,0.00150028422503935,-3.62090569357572,-1.01412406264776,-1.49777258261435,"LOC400756","uncharacterized LOC400756",TRUE
+"239337_at",0.828607509614823,0.399077460305943,0.859854808406093,-5.58584980401977,0.933487811722106,"LOC400768","uncharacterized LOC400768",TRUE
+"1557761_s_at",0.689913893405055,0.159093102715091,1.45718472823616,-4.95521473865632,0.864128245992316,"LOC400794","uncharacterized LOC400794",TRUE
+"1561693_at",0.767727587789514,0.269660135118877,-1.1321876666004,-5.33391318479067,-0.668893320856877,"LOC400794","uncharacterized LOC400794",TRUE
+"1556801_at",0.985425981490741,0.928865165919786,0.0902936437287914,-5.9357132632862,0.0295651484850756,"LOC400794","uncharacterized LOC400794",TRUE
+"225756_at",0.66927199146331,0.135323954825033,1.54993502251854,-4.83280353644493,0.595808310957073,"LOC400927-CSNK1E///CSNK1E","LOC400927-CSNK1E readthrough///casein kinase 1 epsilon",TRUE
+"202332_at",0.754482795130788,0.247659325238,1.18736087557338,-5.27539106536977,0.46033083142636,"LOC400927-CSNK1E///CSNK1E","LOC400927-CSNK1E readthrough///casein kinase 1 epsilon",TRUE
+"234943_at",0.759366666109469,0.256927735827326,1.16369195333336,-5.30079567623709,0.667954354763141,"LOC400927-CSNK1E///LOC400927///CSNK1E","LOC400927-CSNK1E readthrough///TPTE and PTEN homologous inositol lipid phosphatase pseudogene///casein kinase 1 epsilon",TRUE
+"1565684_at",0.601886119917951,0.077026011542129,1.85449797952482,-4.39049610754009,1.02776456120336,"LOC400940","uncharacterized LOC400940",TRUE
+"239168_at",0.977128286470696,0.890846946788636,0.138819311199957,-5.93030174054106,0.0772812388859716,"LOC400940","uncharacterized LOC400940",TRUE
+"1565685_at",0.994145854504594,0.973045140519242,-0.0341730637779439,-5.93911470526625,-0.0299357723344631,"LOC400940","uncharacterized LOC400940",TRUE
+"1570006_at",0.59411810156079,0.0710689098301813,1.89605858056639,-4.32567433491222,1.18340003170532,"LOC400958","uncharacterized LOC400958",TRUE
+"1563860_at",0.837609393049242,0.421755510387201,0.818558090033075,-5.61849843653129,0.408792602984315,"LOC400965","uncharacterized LOC400965",TRUE
+"217076_s_at",0.629618998226163,0.10049445721673,1.71395580798359,-4.60197806871414,1.38957908566827,"LOC401021///HOXD4///HOXD3","uncharacterized LOC401021///homeobox D4///homeobox D3",TRUE
+"206601_s_at",0.896118635245982,0.578059828644426,0.564536957357728,-5.78563637967845,0.495793153803823,"LOC401021///HOXD4///HOXD3","uncharacterized LOC401021///homeobox D4///homeobox D3",TRUE
+"206602_s_at",0.986342822130003,0.934343312587635,-0.08332251691721,-5.93630254154367,-0.0686486762676566,"LOC401021///HOXD4///HOXD3","uncharacterized LOC401021///homeobox D4///homeobox D3",TRUE
+"232812_at",0.847093798440272,0.445802962164068,-0.776260769416546,-5.65037465267006,-0.709370401858595,"LOC401052","uncharacterized LOC401052",TRUE
+"1557754_at",0.0897427148869195,0.00034797358127164,-4.22006526365688,0.27455076343093,-2.05425661622693,"LOC401068","uncharacterized LOC401068",TRUE
+"1556609_at",0.917456746151293,0.650416843851308,-0.459407983474454,-5.83740558587361,-0.361978908367164,"LOC401098","uncharacterized LOC401098",TRUE
+"1557823_s_at",0.858826390511142,0.475088827952966,0.726582035591673,-5.68577252707985,0.477416940997934,"LOC401134","uncharacterized LOC401134",TRUE
+"1557822_at",0.953931868692178,0.787331906235894,-0.273065466562952,-5.90343085615755,-0.223247598574459,"LOC401134","uncharacterized LOC401134",TRUE
+"1562645_at",0.881030044603,0.5369341651559,-0.627206635919072,-5.74987380655274,-0.348222324864891,"LOC401176","uncharacterized LOC401176",TRUE
+"1559760_at",0.914776697425609,0.640950800987969,0.47284178126749,-5.83136904447724,0.312318788126163,"LOC401220","uncharacterized LOC401220",TRUE
+"229914_at",0.715352956634026,0.191076235433383,1.34864258425648,-5.09061551404852,0.494600543769752,"LOC401261","uncharacterized LOC401261",TRUE
+"1559964_at",0.979606049979413,0.90302916932958,0.123238703125985,-5.93228878042323,0.0656441740728866,"LOC401261","uncharacterized LOC401261",TRUE
+"1557605_a_at",0.854163696308241,0.463728252602859,0.745630240284167,-5.6724620401098,0.401232279115298,"LOC401312","uncharacterized LOC401312",TRUE
+"1557604_at",0.859483694145165,0.476994904146939,0.723412509030649,-5.68795557974991,0.557204272901815,"LOC401312","uncharacterized LOC401312",TRUE
+"242329_at",0.857420254968349,0.472910200435766,0.730213926030828,-5.6832598671884,0.337456599709093,"LOC401317///CREB5","uncharacterized LOC401317///cAMP responsive element binding protein 5",TRUE
+"229228_at",0.958325326717984,0.811482817770901,0.241376895181868,-5.91134559159256,0.280092686577368,"LOC401317///CREB5","uncharacterized LOC401317///cAMP responsive element binding protein 5",TRUE
+"205931_s_at",0.976371465776674,0.886324206351524,0.144612485700312,-5.92950277133283,0.102926551664891,"LOC401317///CREB5","uncharacterized LOC401317///cAMP responsive element binding protein 5",TRUE
+"233732_at",0.807528762746328,0.348758072807952,-0.95727479830122,-5.50294314460913,-0.297697542449734,"LOC401320","uncharacterized LOC401320",TRUE
+"1563586_at",0.925511384407886,0.678053857467593,-0.420662167570588,-5.85386002259649,-0.269660326619213,"LOC401324","uncharacterized LOC401324",TRUE
+"1560108_at",0.672329541745581,0.1381705311828,1.53815456954905,-4.84868499309315,1.0527497392108,"LOC401433///NUB1","uncharacterized LOC401433///negative regulator of ubiquitin like proteins 1",TRUE
+"1560109_s_at",0.724970327905974,0.203078650058238,1.31161658890511,-5.13480270486127,0.597955441549082,"LOC401433///NUB1","uncharacterized LOC401433///negative regulator of ubiquitin like proteins 1",TRUE
+"1568827_at",0.983212176432519,0.918255376936421,0.10380832521824,-5.93443616908204,0.0374930984406365,"LOC401442","uncharacterized LOC401442",TRUE
+"1563927_a_at",0.56861088242915,0.0584623544339118,1.99520199350196,-4.16704235936896,1.89188512080943,"LOC401463","uncharacterized LOC401463",TRUE
+"243820_at",0.700595163479743,0.172371397149145,-1.41017908579151,-5.01491167595715,-0.987583764209128,"LOC401463","uncharacterized LOC401463",TRUE
+"1564295_at",0.412444326023181,0.0165075769791164,2.59403797862503,-3.10548381220211,2.46072414182287,"LOC401585","uncharacterized LOC401585",TRUE
+"1555002_at",0.736132227107113,0.221554039009429,1.25781499687162,-5.19714879579761,1.33702958522463,"LOC403312","putative uncharacterized protein MGC39545",TRUE
+"232897_at",0.689022249989218,0.158018289759759,-1.46112625691069,-4.95013656451871,-1.11786899455761,"LOC403323","uncharacterized LOC403323",TRUE
+"1557584_at",0.725168361556674,0.203385766792645,1.31069185277998,-5.13589301585555,0.477183816509251,"LOC403323","uncharacterized LOC403323",TRUE
+"1563221_at",0.80056683899707,0.336499274501543,0.982420710808161,-5.48021958846302,0.812592392517066,"LOC414300","uncharacterized LOC414300",TRUE
+"1558345_a_at",0.717996777972856,0.193986072711079,-1.33950237104614,-5.10161961850344,-0.606053820886907,"LOC439911","uncharacterized LOC439911",TRUE
+"1552987_a_at",0.893334037681196,0.56795518500267,0.579715331890288,-5.77730865314305,0.556185330514274,"LOC439933","uncharacterized LOC439933",TRUE
+"239104_at",0.899798994481376,0.591597584042987,0.544408831713276,-5.79634917833484,0.388769571225257,"LOC439933","uncharacterized LOC439933",TRUE
+"244424_at",0.940964444369914,0.735644922577652,0.341903891927783,-5.88290648069823,0.128911397700232,"LOC439938","uncharacterized LOC439938",TRUE
+"1555209_at",0.482620599503284,0.0275228354687012,2.35945602101232,-3.54038808558223,1.44507937185576,"LOC439951","uncharacterized LOC439951",TRUE
+"1566830_at",0.644237683837193,0.114849285859371,1.641327746485,-4.70638571989053,0.703383395969495,"LOC440028","uncharacterized LOC440028",TRUE
+"1562606_a_at",0.952374805858222,0.782036017993795,-0.280051429389395,-5.90155573312238,-0.210865289684742,"LOC440028","uncharacterized LOC440028",TRUE
+"240268_at",0.914242258486146,0.639540036654302,-0.474851398202527,-5.83045137029856,-0.176822032490742,"LOC440117","uncharacterized LOC440117",TRUE
+"236366_at",0.875279162021058,0.5223868411205,0.649981473771835,-5.73597973759171,0.521236833390762,"LOC440149","uncharacterized LOC440149",TRUE
+"229761_at",0.512957854428756,0.0343658491042567,2.25470789041892,-3.72713714804364,1.57693497081686,"LOC440173","uncharacterized LOC440173",TRUE
+"1569823_at",0.831264145663735,0.405407561849538,0.848180607032183,-5.59523131640661,0.71815560511959,"LOC440346","uncharacterized LOC440346",TRUE
+"215090_x_at",0.713165319254365,0.187699111917152,1.35938891955172,-5.07759769619176,0.585799530523936,"LOC440434","aminopeptidase puromycin sensitive pseudogene",TRUE
+"214107_x_at",0.73826901296725,0.225146623046859,1.24775719483953,-5.20855621302559,0.607944875425366,"LOC440434","aminopeptidase puromycin sensitive pseudogene",TRUE
+"242884_at",0.929972194057784,0.691042523257674,-0.402679954518267,-5.86101275947914,-0.264616159882506,"LOC440570","uncharacterized LOC440570",TRUE
+"1561335_at",0.90056027029015,0.595580408110133,-0.538530523672718,-5.79940650751517,-0.289473641411802,"LOC440602","uncharacterized LOC440602",TRUE
+"1562558_at",0.903985627315424,0.605980379089851,-0.523270451278068,-5.80719258680359,-0.386433656131307,"LOC440704","uncharacterized LOC440704",TRUE
+"215682_at",0.62745883741359,0.0990392275606635,-1.72180157549171,-4.59049581200988,-1.15823949992064,"LOC440792","proline dehydrogenase 1 pseudogene",TRUE
+"215678_at",0.774447611376107,0.290815051276987,1.0821687130443,-5.38483922189904,0.319455319040823,"LOC440792","proline dehydrogenase 1 pseudogene",TRUE
+"1557372_at",0.868313695469383,0.502570300302638,0.681575117026346,-5.71591898781465,0.258800991561117,"LOC440862///ATP6V1E2","uncharacterized LOC440862///ATPase H+ transporting V1 subunit E2",TRUE
+"1569034_a_at",0.534005258361339,0.0422952490996256,2.15491740887485,-3.90030663342118,0.765968237174396,"LOC440864///MSH6","uncharacterized LOC440864///mutS homolog 6",TRUE
+"238727_at",0.827985973549523,0.397630136396705,0.862540690260643,-5.58367450372079,0.826465716251162,"LOC440934","uncharacterized LOC440934",TRUE
+"230844_at",0.835223580564215,0.414271165190602,0.832027882366541,-5.60801441103012,0.404007957522712,"LOC440934","uncharacterized LOC440934",TRUE
+"241440_at",0.857381762624307,0.4728732885585,0.73027554476842,-5.68321713467987,0.596051837568495,"LOC440982///ZIC1","uncharacterized LOC440982///Zic family member 1",TRUE
+"1562983_at",0.843461221384182,0.438178294469373,0.789516107447718,-5.64055628926803,0.683004413780633,"LOC441025","uncharacterized LOC441025",TRUE
+"232443_at",0.943988850936011,0.749631334267025,-0.323123666853146,-5.88895730938903,-0.219229538512374,"LOC441052","uncharacterized LOC441052",TRUE
+"1558011_at",0.706668000657573,0.178531414596855,1.38935206007428,-5.04084712319972,1.1492007013318,"LOC441081","POM121 membrane glycoprotein (rat) pseudogene",TRUE
+"1562920_at",0.976371465776674,0.887022536196873,-0.143717669782228,-5.9296283090296,-0.0537750568332811,"LOC441086","uncharacterized LOC441086",TRUE
+"205788_s_at",0.711870026066379,0.185340097321535,-1.36698633697373,-5.06834236346236,-0.457906223171957,"LOC441155///ZC3H11A","zinc finger CCCH-type domain-containing-like///zinc finger CCCH-type containing 11A",TRUE
+"205787_x_at",0.80764044633141,0.349069458726385,-0.956643972468202,-5.50350627825833,-0.368201758766769,"LOC441155///ZC3H11A","zinc finger CCCH-type domain-containing-like///zinc finger CCCH-type containing 11A",TRUE
+"1565867_a_at",0.837368340567858,0.421171280488874,-0.819604111221284,-5.617690020075,-0.426283119980297,"LOC441155///ZC3H11A","zinc finger CCCH-type domain-containing-like///zinc finger CCCH-type containing 11A",TRUE
+"1563894_at",0.892856334334787,0.566302579211608,0.58221078401327,-5.775919027057,0.284542126458291,"LOC441178","uncharacterized LOC441178",TRUE
+"1561685_a_at",0.98529096111871,0.927107756063291,0.0925309617820058,-5.93551411676909,0.0750171089944747,"LOC441178","uncharacterized LOC441178",TRUE
+"239665_at",0.670152406964446,0.135827522074773,1.54783624283816,-4.83563995638977,1.12718818083962,"LOC441179","uncharacterized LOC441179",TRUE
+"240424_s_at",0.580748061056528,0.063481527025644,1.95366041318623,-4.23418315787725,1.27741891663883,"LOC441204","uncharacterized LOC441204",TRUE
+"215297_at",0.62986301194198,0.101148315597375,1.71046204988087,-4.60707855160818,0.702038920552347,"LOC441204","uncharacterized LOC441204",TRUE
+"240423_at",0.767011398042819,0.268451803454644,1.13512984012496,-5.33085424814752,0.787997085364113,"LOC441204","uncharacterized LOC441204",TRUE
+"240194_at",0.978906483701268,0.89699524158086,-0.130951720579824,-5.93133460015477,-0.0932516967276209,"LOC441204","uncharacterized LOC441204",TRUE
+"236929_at",0.868397087637799,0.50373759014668,0.679694978149878,-5.71713830362646,0.327197846019299,"LOC441242","uncharacterized LOC441242",TRUE
+"239321_at",0.940227139261806,0.732822147975441,-0.345709197450296,-5.88163926443624,-0.266407641906655,"LOC441454","prothymosin, alpha pseudogene",TRUE
+"214381_at",0.860085676417428,0.47918006188812,0.719788014599521,-5.69044087610069,0.428165784159359,"LOC441601","septin 7 pseudogene",TRUE
+"1562527_at",0.672709959259086,0.138540725034427,1.53663726786241,-4.85072352018637,1.72033309709112,"LOC441666","zinc finger protein 91 pseudogene",TRUE
+"1559503_a_at",0.955816406528307,0.798809316215936,0.257972283769461,-5.90732145764165,0.178599798159329,"LOC441666","zinc finger protein 91 pseudogene",TRUE
+"1560380_at",0.732963666545614,0.21739970691438,-1.26960242019741,-5.1836798455568,-0.559152878192199,"LOC497256","uncharacterized LOC497256",TRUE
+"220752_at",0.979588787486838,0.902353982567304,0.124101388127634,-5.93218492911522,0.0758509497892303,"LOC51145","uncharacterized LOC51145",TRUE
+"243977_at",0.299994279961527,0.00556007211666223,3.07105944946876,-2.16362142746622,1.19594324932757,"LOC541472","uncharacterized LOC541472",TRUE
+"1556992_at",0.896428361916712,0.58090501031845,-0.560287373472443,-5.78792956509931,-0.397498373946465,"LOC550113///UBA6-AS1","uncharacterized LOC550113///UBA6 antisense RNA 1 (head to head)",TRUE
+"241899_at",0.950980582261399,0.776193281420805,-0.287775321022088,-5.89942782665064,-0.101541008724623,"LOC553103","uncharacterized LOC553103",TRUE
+"215187_at",0.591580108376627,0.0689526946940611,1.91155884103602,-4.30124120363689,1.23655489471896,"LOC55338","uncharacterized LOC55338",TRUE
+"217335_at",0.71242055183987,0.186456875175515,1.36338019485665,-5.07274080411607,0.862920447169007,"LOC55338","uncharacterized LOC55338",TRUE
+"220828_s_at",0.951290104727482,0.77708025258992,0.286601636704627,-5.89975487360611,0.166956684439298,"LOC55338","uncharacterized LOC55338",TRUE
+"217342_x_at",0.985577528508055,0.930433961856421,0.0882968448924769,-5.93588688778077,0.0441936224659374,"LOC55338","uncharacterized LOC55338",TRUE
+"1554949_at",0.852064935533376,0.457513684061201,-0.756167639424487,-5.66495850847385,-0.433616302803538,"LOC554174","uncharacterized LOC554174",TRUE
+"1554187_at",0.543844633515776,0.0463822135543495,-2.10994763452882,-3.97674658336219,-1.26931443202379,"LOC554206","leucine carboxyl methyltransferase 1 pseudogene",TRUE
+"1554185_at",0.676020192063893,0.142452347158569,-1.52080524799737,-4.87189878878172,-0.549275897011322,"LOC554206","leucine carboxyl methyltransferase 1 pseudogene",TRUE
+"1555244_at",0.909934011695618,0.625055658183618,-0.495601298263939,-5.82075365510349,-0.458263104260661,"LOC554207","uncharacterized LOC554207",TRUE
+"220893_at",0.785175995766517,0.310540075022217,1.03783713329862,-5.4282551542007,0.619019363126139,"LOC57399","uncharacterized gastric protein ZA52P",TRUE
+"1562251_a_at",0.743323328391634,0.23344809734304,1.22497595154193,-5.23410280924219,0.664988515176794,"LOC574538","uncharacterized LOC574538",TRUE
+"1559459_at",0.878788356961452,0.532176417007996,-0.634617950857921,-5.74540474251945,-0.584018277680156,"LOC613266","uncharacterized LOC613266",TRUE
+"1563654_at",0.88440457468396,0.54366415647239,0.616783043824167,-5.75607372937237,0.64852730633975,"LOC619427","uncharacterized LOC619427",TRUE
+"228839_s_at",0.147686070612109,0.00103143889590755,-3.77539619520887,-0.6838728803604,-1.33077533140335,"LOC642361///LINC00863","uncharacterized LOC642361///long intergenic non-protein coding RNA 863",TRUE
+"1562223_at",0.998870448604467,0.995913885895793,-0.00517929955348623,-5.939670415219,-0.00577066970607221,"LOC642426","uncharacterized LOC642426",TRUE
+"1556129_at",0.700061364939874,0.17185767533785,-1.41194267225916,-5.01270091318545,-0.575945928580847,"LOC642533","uncharacterized LOC642533",TRUE
+"220730_at",0.748438284778152,0.241184030465287,-1.20429287053884,-5.2569439589809,-0.417339239730801,"LOC642533","uncharacterized LOC642533",TRUE
+"1564548_at",0.709346162928153,0.182158952316552,1.37735349963985,-5.05564360177381,1.19798307612354,"LOC642620","uncharacterized LOC642620",TRUE
+"1564327_at",0.837277736441724,0.419814415865198,0.822036996082018,-5.61580602632711,0.649635509609585,"LOC642696","uncharacterized LOC642696",TRUE
+"213378_s_at",0.597654932724127,0.0738308320530615,1.87642576321134,-4.35642163812977,0.580637857557571,"LOC642846///DDX12P///DDX11","DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11-like///DEAD/H-box helicase 12, pseudogene///DEAD/H-box helicase 11",TRUE
+"228908_s_at",0.609499207369658,0.0817063194643557,-1.82376615406591,-4.4377711109839,-0.856256308365507,"LOC642852","uncharacterized LOC642852",TRUE
+"228909_at",0.626123824677003,0.0970176287805718,-1.73286568183385,-4.57423712037749,-0.678829383219772,"LOC642852","uncharacterized LOC642852",TRUE
+"226995_at",0.701770809769283,0.173315249095832,-1.40694979978561,-5.01895388495105,-0.45757937509733,"LOC642852","uncharacterized LOC642852",TRUE
+"1559957_a_at",0.737123149977386,0.222869194609472,-1.25411871387397,-5.20135020021909,-0.86923958829881,"LOC642852","uncharacterized LOC642852",TRUE
+"1569032_at",0.917102138198416,0.649525486988115,0.460669266091158,-5.83684607099208,0.268911445545242,"LOC642852","uncharacterized LOC642852",TRUE
+"243656_at",0.989638901366417,0.949999086540925,0.0634221025967906,-5.93772452587724,0.0257344701937354,"LOC642852","uncharacterized LOC642852",TRUE
+"243129_at",0.90360437116293,0.604804673876301,0.524989225932359,-5.80632651105029,0.157570334922758,"LOC642980","uncharacterized LOC642980",TRUE
+"228412_at",0.763650705722297,0.263527389294915,-1.14722196118031,-5.31820877954412,-0.586774489938916,"LOC643072","uncharacterized LOC643072",TRUE
+"229224_x_at",0.980135507384952,0.906638715459534,0.118628399798933,-5.93283151239296,0.127804416231112,"LOC643085","uncharacterized LOC643085",TRUE
+"1570445_a_at",0.774230543658252,0.286460197802311,-1.09224445748087,-5.37474527601565,-0.568528197012284,"LOC643201","centrosomal protein 192kDa pseudogene",TRUE
+"235416_at",0.868362861768355,0.503086639403281,-0.680743152395433,-5.71645893437543,-0.211572248950341,"LOC643201","centrosomal protein 192kDa pseudogene",TRUE
+"1570444_at",0.936318756756998,0.715891416061395,-0.368644930896331,-5.87370794490161,-0.237228010136426,"LOC643201","centrosomal protein 192kDa pseudogene",TRUE
+"1568794_at",0.812302873476553,0.360823605389256,-0.933104847222739,-5.52427614068245,-0.420055477251454,"LOC643355","uncharacterized LOC643355",TRUE
+"243402_at",0.993225426079816,0.968022218831406,0.0405444278114402,-5.93888285343411,0.0203232877923618,"LOC643406///LINC00654","uncharacterized LOC643406///long intergenic non-protein coding RNA 654",TRUE
+"1560162_at",0.888610474399596,0.554852873688572,-0.599604085835526,-5.76607302883027,-0.407751403910664,"LOC643549","uncharacterized LOC643549",TRUE
+"222044_at",0.776936981479994,0.295305585796698,-1.07189199801753,-5.39504845764429,-0.372552500271322,"LOC643549///PCIF1","uncharacterized LOC643549///PDX1 C-terminal inhibiting factor 1",TRUE
+"1569647_at",0.961212424803935,0.824271543750385,0.224700564553672,-5.91512137371251,0.16798078922028,"LOC643623","uncharacterized LOC643623",TRUE
+"1564758_at",0.666643938027574,0.133486619958365,1.55764782565471,-4.8223539325025,1.02749041145028,"LOC643659","hCG2019139",TRUE
+"237957_at",0.888312537451395,0.554336268226871,-0.600393239715981,-5.76561966330341,-0.41016293260212,"LOC643711","platelet activating factor acetylhydrolase 1b catalytic subunit 2 pseudogene",TRUE
+"1570009_at",0.896429801062725,0.580978326486651,0.560178005933187,-5.78798836080127,0.314169673965726,"LOC643711","platelet activating factor acetylhydrolase 1b catalytic subunit 2 pseudogene",TRUE
+"1564533_at",0.975398143273847,0.881012162420268,-0.151423171208627,-5.92852178838302,-0.134062832054408,"LOC643711","platelet activating factor acetylhydrolase 1b catalytic subunit 2 pseudogene",TRUE
+"240890_at",0.789795896476304,0.31804581946478,1.02149215867651,-5.44385014991084,0.763383222499194,"LOC643733","caspase 4, apoptosis-related cysteine peptidase pseudogene",TRUE
+"208340_at",0.932477653323999,0.702099818095822,0.387477614969705,-5.86681975726058,0.256582844695796,"LOC643733","caspase 4, apoptosis-related cysteine peptidase pseudogene",TRUE
+"1564787_at",0.44258805251056,0.0205659929957707,2.49418711951385,-3.29325810829219,1.39245216295919,"LOC643923///ELMOD1","uncharacterized LOC643923///ELMO domain containing 1",TRUE
+"231930_at",0.813442508625161,0.363743079761911,-0.927338429058188,-5.52929169288793,-0.70703053620642,"LOC643923///ELMOD1","uncharacterized LOC643923///ELMO domain containing 1",TRUE
+"238319_at",0.767965891104819,0.270805488895843,1.12940774931217,-5.33679698579347,0.381032761303355,"LOC644090","uncharacterized LOC644090",TRUE
+"1562749_at",0.956768941747255,0.80436191925007,-0.250692561953708,-5.90911941471227,-0.175674028468491,"LOC644090","uncharacterized LOC644090",TRUE
+"1559124_at",0.619611160248431,0.0896915108877211,-1.77468891408228,-4.51208298706305,-1.14658701649574,"LOC644135","uncharacterized LOC644135",TRUE
+"240581_at",0.901639484915293,0.598470938217849,0.534276349769681,-5.8015989868599,0.42885189957013,"LOC644135","uncharacterized LOC644135",TRUE
+"213013_at",0.589349984422749,0.0678008486880492,-1.92017184308075,-4.28760475620207,-1.07137283795617,"LOC644172///MAPK8IP1","mitogen-activated protein kinase 8 interacting protein 1 pseudogene///mitogen-activated protein kinase 8 interacting protein 1",TRUE
+"229870_at",0.803090482955976,0.340713065251885,-0.973707548326545,-5.48815426166589,-0.805075245292147,"LOC644656","uncharacterized LOC644656",TRUE
+"238921_at",0.850622134716209,0.453431771674511,0.76313568430992,-5.65994194498171,0.26521233045395,"LOC644794","uncharacterized LOC644794",TRUE
+"235884_at",0.990605394412423,0.952303797635324,-0.0604949436273408,-5.93790116309761,-0.0283177065491209,"LOC644794","uncharacterized LOC644794",TRUE
+"1554307_at",0.741260241503758,0.231860719168462,1.22928394488797,-5.22930300221118,0.656948304890451,"LOC644852","uncharacterized LOC644852",TRUE
+"1560895_at",0.616413638398853,0.0872675647647464,1.78917389154622,-4.49030330716582,1.38677323232525,"LOC645188","uncharacterized LOC645188",TRUE
+"1555400_at",0.734935310038702,0.220012130670276,1.26217003491453,-5.19218501865005,0.614549479437501,"LOC645261","PP565",TRUE
+"236643_s_at",0.90344422113846,0.60411831319781,0.525993363454156,-5.80581925501982,0.338273953134082,"LOC645321","uncharacterized LOC645321",TRUE
+"230889_at",0.955816406528307,0.798874056040729,0.257887325484559,-5.90734273569431,0.182923555491174,"LOC645321","uncharacterized LOC645321",TRUE
+"1560251_at",0.795497760925102,0.32767664157351,-1.00091023853979,-5.4631690939646,-0.766815007377577,"LOC645485","uncharacterized LOC645485",TRUE
+"239556_at",0.431769566611896,0.0191939614299758,-2.5257048464083,-3.23439462773567,-1.62383500552821,"LOC645513","septin 7 pseudogene",TRUE
+"1561759_at",0.828941412891522,0.399872256755726,0.858382524447186,-5.58703952955045,0.707794974846494,"LOC645513","septin 7 pseudogene",TRUE
+"1561761_x_at",0.830635993561085,0.403517583192909,-0.851653869344434,-5.59245265572673,-0.665343123469537,"LOC645513","septin 7 pseudogene",TRUE
+"1561760_s_at",0.837345289209351,0.420103078795286,-0.821519004858908,-5.6162075901798,-0.302431522949504,"LOC645513","septin 7 pseudogene",TRUE
+"242305_at",0.897011777275924,0.582568852850884,-0.557807074429227,-5.78926022972907,-0.254490272521563,"LOC645513","septin 7 pseudogene",TRUE
+"1556257_at",0.904877208521835,0.610315869207339,-0.516946075006209,-5.81035556516933,-0.438194388756921,"LOC645513","septin 7 pseudogene",TRUE
+"1560007_at",0.684874883853079,0.153391126458377,1.47834705575697,-4.92781944645965,1.09548946225332,"LOC645984","uncharacterized LOC645984",TRUE
+"238715_at",0.948815741515659,0.767180768943726,0.299724880654067,-5.89602263563355,0.216308546712456,"LOC646014","uncharacterized LOC646014",TRUE
+"236283_x_at",0.633098477100746,0.104359773494113,1.69357612562407,-4.6316199028202,0.461311992753977,"LOC646214","p21 protein (Cdc42/Rac)-activated kinase 2 pseudogene",TRUE
+"244268_x_at",0.813631136157676,0.364348646821755,0.926146220343123,-5.53032509205372,0.266064985939876,"LOC646214","p21 protein (Cdc42/Rac)-activated kinase 2 pseudogene",TRUE
+"1559790_at",0.958325326717984,0.811541608127046,0.241300076710549,-5.91136360060075,0.11061763013688,"LOC646241","uncharacterized LOC646241",TRUE
+"1561027_at",0.966593471043185,0.844658242800736,-0.198248646172094,-5.92055877960095,-0.188738205556003,"LOC646241","uncharacterized LOC646241",TRUE
+"1568745_at",0.66071672549246,0.128687784417403,1.57821505221337,-4.79428936657424,0.760636344705945,"LOC646268","hCG1654703",TRUE
+"1568746_a_at",0.846248434359032,0.444259146070549,0.778933410488397,-5.64840761352512,0.564371562782565,"LOC646268","hCG1654703",TRUE
+"1562217_at",0.774230543658252,0.288039413268242,1.08857798247202,-5.37842802490571,0.600033017141948,"LOC646383","uncharacterized LOC646383",TRUE
+"1569517_at",0.99420041915836,0.973555138556161,0.0335262383976313,-5.93913603240107,0.0176036515686953,"LOC646482","uncharacterized LOC646482",TRUE
+"244649_at",0.95599181039166,0.801226003257298,-0.254802166802344,-5.90811070437175,-0.177269286296168,"LOC646484","uncharacterized LOC646484",TRUE
+"1563013_at",0.865854896594418,0.496010141821706,-0.692187796678083,-5.70897605537023,-0.458822160480806,"LOC646522","uncharacterized LOC646522",TRUE
+"236977_at",0.952996239249347,0.784620497664551,0.276640409408394,-5.90247716915159,0.119922720127727,"LOC646588","uncharacterized LOC646588",TRUE
+"244619_at",0.70375640697234,0.175285866486499,1.4002525548118,-5.0273127042467,0.894545034943701,"LOC646626","uncharacterized LOC646626",TRUE
+"1570289_at",0.868285886165517,0.50240528566753,0.681841102929211,-5.71574622946161,0.43716187802795,"LOC646736","uncharacterized LOC646736",TRUE
+"1560806_at",0.885694554133555,0.54746767485922,0.610922435496034,-5.75951561661547,0.455248222724881,"LOC646743///TISP43","uncharacterized LOC646743///uncharacterized LOC150527",TRUE
+"1568597_at",0.799150634740328,0.333797897676453,-0.988046057292703,-5.47506265619818,-0.411231042080781,"LOC646762","uncharacterized LOC646762",TRUE
+"1560006_a_at",0.999503346640971,0.998843711284753,0.00146563207278307,-5.93968243449987,0.000526154001192047,"LOC646762","uncharacterized LOC646762",TRUE
+"242489_at",0.884461257577679,0.543715177474959,-0.616704284929458,-5.75612019383648,-0.347027274216511,"LOC646778","uncharacterized LOC646778",TRUE
+"243452_at",0.988098729256575,0.943225402420835,-0.0720285849436364,-5.93715685611465,-0.0361950829738342,"LOC646778","uncharacterized LOC646778",TRUE
+"237116_at",0.960198517898473,0.819730337657428,-0.230614530841388,-5.91381311913105,-0.144192635125987,"LOC646903","uncharacterized LOC646903",TRUE
+"1562145_at",0.873230718105642,0.517833337494747,0.657181382270162,-5.73148835579104,0.332152228894436,"LOC647070","nascent polypeptide-associated complex subunit alpha, muscle-specific form-like",TRUE
+"215468_at",0.92563477467988,0.678544888325004,0.419979824023195,-5.85413704510591,0.414371179443245,"LOC647070","nascent polypeptide-associated complex subunit alpha, muscle-specific form-like",TRUE
+"215467_x_at",0.980326403741224,0.908247867177934,-0.116573960573252,-5.93306670886022,-0.0408114726059878,"LOC647070","nascent polypeptide-associated complex subunit alpha, muscle-specific form-like",TRUE
+"231698_at",0.85334340854827,0.460973115490813,0.750291360575166,-5.6691552210953,0.560682005333634,"LOC647115","translation initiation factor IF-2",TRUE
+"1564539_at",0.860771082151018,0.480693615936297,0.717283152723096,-5.69215150797594,0.548650316131279,"LOC647323","uncharacterized LOC647323",TRUE
+"1569009_s_at",0.402463840838386,0.0148693633663577,-2.64102931647267,-3.015849385275,-2.32940382190445,"LOC648761///FAM201B","uncharacterized LOC648761///family with sequence similarity 201 member B",TRUE
+"1569008_at",0.803988341675731,0.342565905284425,0.969899658409048,-5.49160168582699,0.26191011885776,"LOC648761///FAM201B","uncharacterized LOC648761///family with sequence similarity 201 member B",TRUE
+"227901_at",0.821561540371535,0.384089478933911,0.887981005061056,-5.56275790988327,0.512696422501077,"LOC648987","uncharacterized LOC648987",TRUE
+"1553130_at",0.841550580403629,0.433284784816812,-0.798098138951121,-5.63411603668336,-0.710788276810598,"LOC652276","potassium channel tetramerization domain containing 5 pseudogene",TRUE
+"1556730_at",0.62524538993269,0.0965418412680148,1.73549823675612,-4.57035718059297,0.830110598369373,"LOC652993","uncharacterized LOC652993",TRUE
+"236246_x_at",0.766550448794594,0.267245258255264,1.1380773794958,-5.3277827108821,0.962886746299029,"LOC653160","uncharacterized LOC653160",TRUE
+"1554391_at",0.567293479905907,0.0575016796368612,-2.00351159586828,-4.15349795796048,-1.2594751601072,"LOC653581","uncharacterized LOC653581",TRUE
+"229546_at",0.830635993561085,0.404419491967245,0.849995113849508,-5.59378100523064,0.976423985927436,"LOC653602///FAM84A","uncharacterized LOC653602///family with sequence similarity 84 member A",TRUE
+"243419_at",0.823074246722209,0.389070627631542,0.878555631525115,-5.57057309912376,0.490045065067797,"LOC654342","lymphocyte-specific protein 1 pseudogene",TRUE
+"239718_at",0.980439435497171,0.908684462698555,0.116016638515832,-5.93312980468464,0.0391063326936925,"LOC654342","lymphocyte-specific protein 1 pseudogene",TRUE
+"214110_s_at",0.710842845257879,0.184324885486574,-1.37027944947021,-5.06431727405808,-1.08318130369904,"LOC654342///LOC645166","lymphocyte-specific protein 1 pseudogene///lymphocyte-specific protein 1 pseudogene",TRUE
+"242133_s_at",0.992816117752561,0.965993111568424,-0.0431187372963712,-5.93877796112638,-0.0407448821460807,"LOC654342///LOC645166","lymphocyte-specific protein 1 pseudogene///lymphocyte-specific protein 1 pseudogene",TRUE
+"1562428_at",0.899208835355228,0.58952246370934,0.547479223929889,-5.7947394327679,0.400611073984984,"LOC654780","splicing factor proline/glutamine-rich",TRUE
+"1557862_at",0.892746695408886,0.565632730682542,-0.583223325366382,-5.77535353227412,-0.38608450953958,"LOC654841","uncharacterized LOC654841",TRUE
+"1569452_at",0.8751553586947,0.522049478225908,-0.650513717049313,-5.73564934380575,-0.372192543113273,"LOC692247","uncharacterized LOC692247",TRUE
+"1561355_at",0.936318756756998,0.715714164011161,-0.368886097752114,-5.87362187629494,-0.506399930133539,"LOC692247","uncharacterized LOC692247",TRUE
+"1569453_a_at",0.953983577550391,0.787821597336951,0.272420206498553,-5.90360168008147,0.238513463829432,"LOC692247","uncharacterized LOC692247",TRUE
+"231247_s_at",0.453601396285638,0.0219079747136688,2.4652000521367,-3.34705243664306,1.32409554295058,"LOC727820","uncharacterized LOC727820",TRUE
+"227383_at",0.552420073963858,0.049676844334033,2.07622138206521,-4.03339829978399,1.96431577680709,"LOC727820","uncharacterized LOC727820",TRUE
+"227384_s_at",0.593337376134677,0.0699889229191138,1.90391762477638,-4.31330341164437,1.5595482397686,"LOC727820","uncharacterized LOC727820",TRUE
+"1559322_at",0.988932182173772,0.946475077169983,0.0678989705826361,-5.93743823756145,0.0405589201998326,"LOC727916","uncharacterized LOC727916",TRUE
+"231256_at",0.79782885150643,0.331472158273887,-0.992914370474178,-5.4705781048403,-0.996231066679398,"LOC727944","uncharacterized LOC727944",TRUE
+"239444_at",0.962555471240652,0.829739523119113,-0.217590508830489,-5.91664944464884,-0.193351599912197,"LOC728024","chromosome X open reading frame 56 pseudogene",TRUE
+"240380_at",0.96827357703393,0.851124428207603,0.189889764664667,-5.92213614362489,0.100761289194627,"LOC728040","hCG1813624",TRUE
+"233599_at",0.89732810490777,0.583588396045127,0.556288982612323,-5.79007184997157,0.351771129834715,"LOC728061","hCG2003663",TRUE
+"1564559_at",0.64151601844823,0.111888372234519,-1.65565377414574,-4.68606314697545,-0.889574672191276,"LOC728073","uncharacterized LOC728073",TRUE
+"1559595_at",0.994083192910649,0.972556087279077,0.0347933391139588,-5.93909387079652,0.0136469520605571,"LOC728084","uncharacterized LOC728084",TRUE
+"239974_at",0.868039927215454,0.501774606766617,0.682858145137449,-5.71508506433209,0.441932276681224,"LOC728095","uncharacterized LOC728095",TRUE
+"1561221_x_at",0.785278808318094,0.310765021958456,1.03734325656524,-5.42872963950983,0.717767370498693,"LOC728099","uncharacterized LOC728099",TRUE
+"1561218_s_at",0.799008022536007,0.333558696600295,0.988545678859481,-5.47460334204027,0.75121017681814,"LOC728099","uncharacterized LOC728099",TRUE
+"1569842_at",0.981557175782601,0.912335374972064,0.111357638595785,-5.93364544718041,0.074501443952443,"LOC728114","uncharacterized LOC728114",TRUE
+"1554732_at",0.668739504090464,0.135015223263113,1.55122495136284,-4.83105874125119,0.83783955866802,"LOC728175","uncharacterized LOC728175",TRUE
+"1554733_at",0.925246803459608,0.676263237339912,0.42315216344695,-5.85284536705852,0.49721066198979,"LOC728175","uncharacterized LOC728175",TRUE
+"1568906_at",0.615637099066718,0.0860984292373715,1.79628474026738,-4.47956422118447,0.8889817230997,"LOC728196","uncharacterized LOC728196",TRUE
+"1564157_at",0.990810941805126,0.955188265534977,-0.056832209170775,-5.93811043798593,-0.0174487926170626,"LOC728283","uncharacterized LOC728283",TRUE
+"1558529_s_at",0.978926990556789,0.897052385566932,0.130878637448648,-5.93134391260088,0.0613282932686054,"LOC728323","uncharacterized LOC728323",TRUE
+"1559927_a_at",0.730048787941067,0.212471029903245,-1.28381369693719,-5.16729866538788,-0.876752297763616,"LOC728353","uncharacterized LOC728353",TRUE
+"1559926_at",0.891249845423426,0.560536954330228,-0.590946380563647,-5.77100900629852,-0.327659041219198,"LOC728353","uncharacterized LOC728353",TRUE
+"218380_at",0.575986890549489,0.0610858383751287,1.97311133737,-4.20286508390593,2.03961828682251,"LOC728392","uncharacterized LOC728392",TRUE
+"1561579_at",0.986421906591669,0.936142341068478,-0.0810341321153193,-5.93648567184831,-0.0518273320343239,"LOC728445","uncharacterized LOC728445",TRUE
+"242070_at",0.953117405378347,0.784818318897378,-0.276379461719136,-5.90254719874078,-0.314446232206616,"LOC728485","uncharacterized LOC728485",TRUE
+"235358_at",0.99164669139131,0.960494715817108,-0.0500960532087124,-5.93846121395353,-0.0268676291928713,"LOC728485","uncharacterized LOC728485",TRUE
+"224623_at",0.990623482682449,0.952580253372314,-0.0601438606398573,-5.93792178866519,-0.021354223492775,"LOC728554///THOC3","THO complex 3 pseudogene///THO complex 3",TRUE
+"229283_at",0.632216562924782,0.103203655693702,-1.69960349551725,-4.62288095355687,-1.18783227166992,"LOC728613","programmed cell death 6 pseudogene",TRUE
+"1569110_x_at",0.739340500562926,0.226774390045205,-1.24324040981955,-5.21365348627052,-1.44106241558195,"LOC728613","programmed cell death 6 pseudogene",TRUE
+"1568762_at",0.356547077571111,0.00963065210124287,-2.8333867273845,-2.64125131540963,-2.39123889107804,"LOC728613///PDCD6","programmed cell death 6 pseudogene///programmed cell death 6",TRUE
+"1568764_x_at",0.685360765794715,0.15401156789559,-1.47601370779526,-4.93085570637531,-1.30822520989351,"LOC728613///PDCD6","programmed cell death 6 pseudogene///programmed cell death 6",TRUE
+"239343_at",0.372215385165384,0.0112605924351631,-2.76465027540887,-2.7764579794238,-1.90756807287349,"LOC728705///TMEM263","uncharacterized LOC728705///transmembrane protein 263",TRUE
+"230579_at",0.953516309041226,0.785587574050804,-0.27536491673623,-5.90281884514233,-0.0799157796462087,"LOC728705///TMEM263","uncharacterized LOC728705///transmembrane protein 263",TRUE
+"242835_s_at",0.737123149977386,0.222831514074491,1.25422438356774,-5.20123023730978,0.631876560848643,"LOC728730","uncharacterized LOC728730",TRUE
+"242313_at",0.82706053436911,0.395748654781247,0.866041698810911,-5.58082955562054,0.460066678403137,"LOC728730","uncharacterized LOC728730",TRUE
+"225907_at",0.59741849655321,0.0734947413372365,1.87878016456912,-4.3527462350103,0.630781123482587,"LOC728743","zinc finger protein pseudogene",TRUE
+"235499_at",0.933609099853387,0.706297022852503,0.381731452879634,-5.86895732884356,0.212080271455708,"LOC728743","zinc finger protein pseudogene",TRUE
+"225909_at",0.82064687791745,0.381332803042938,-0.89323158669322,-5.5583708045254,-0.329413174120163,"LOC728743///ZNF775","zinc finger protein pseudogene///zinc finger protein 775",TRUE
+"1561472_at",0.999016635322945,0.996897093856142,-0.00393303960807493,-5.93967594646949,-0.00342794179742523,"LOC728805","uncharacterized LOC728805",TRUE
+"1559586_at",0.92051722798026,0.662060555553927,-0.443000345597093,-5.84454709126863,-0.35547004781237,"LOC728868","uncharacterized LOC728868",TRUE
+"1555872_a_at",0.867026157046741,0.49860888843499,-0.687974202228976,-5.71174490240577,-0.363608910785411,"LOC728903///GLIDR","uncharacterized LOC728903///glioblastoma down-regulated RNA",TRUE
+"1563053_at",0.571677937624457,0.0596319738568783,-1.98524708225331,-4.18321876304612,-1.4907398102951,"LOC729083","uncharacterized LOC729083",TRUE
+"220823_at",0.707898177720919,0.179714436681381,1.38541795742552,-5.04571033516867,0.868796626777121,"LOC729164","hCG1732469",TRUE
+"1564229_at",0.877488742289724,0.527520538774996,0.641905382607105,-5.74096115623208,0.248141197267958,"LOC729173","uncharacterized LOC729173",TRUE
+"231821_x_at",0.975196332002567,0.879576258187006,0.153265420815335,-5.92824869931009,0.100157871335941,"LOC729218///GTF2IP20///LINC01061","uncharacterized LOC729218///general transcription factor IIi pseudogene 20///long intergenic non-protein coding RNA 1061",TRUE
+"1556536_at",0.725333048227278,0.204181087247664,1.308302162145,-5.13870757071565,0.630669000605447,"LOC729224","uncharacterized LOC729224",TRUE
+"240518_at",0.7580556532611,0.254681742931013,1.16936848535201,-5.29474366095255,0.499264793619365,"LOC729291","translation initiation factor IF-2",TRUE
+"1570572_at",0.921729477898827,0.666369306648963,0.436960125402519,-5.84711196133321,0.379848023193475,"LOC729291","translation initiation factor IF-2",TRUE
+"237805_at",0.744863302188406,0.236394476809753,1.21703821897383,-5.24290858689214,0.554891944281519,"LOC729296","uncharacterized LOC729296",TRUE
+"237806_s_at",0.813065886130395,0.362484630749644,0.929820248910005,-5.52713654424041,0.646174893500603,"LOC729296///MIR646HG","uncharacterized LOC729296///MIR646 host gene",TRUE
+"1562051_at",0.831875452294783,0.407733144443474,0.843920984863133,-5.59862461427712,0.467142387803887,"LOC729296///MIR646HG","uncharacterized LOC729296///MIR646 host gene",TRUE
+"1569811_at",0.896088893964183,0.577086164524424,-0.56599364096876,-5.78484644851577,-0.393563530735352,"LOC729307","uncharacterized LOC729307",TRUE
+"1566524_a_at",0.839781238235762,0.428607082048664,0.806357894493732,-5.62785582655836,0.35836672178659,"LOC729324","hCG1986447",TRUE
+"233338_at",0.591612013981201,0.068970004153931,1.9114303748678,-4.30144427432678,0.777915107483952,"LOC729461///FAM230B///FAM230C","uncharacterized LOC729461///family with sequence similarity 230 member B (non-protein coding)///family with sequence similarity 230 member C",TRUE
+"1561061_at",0.675447258877226,0.14175447160225,1.52360345472656,-4.86816889015737,0.437403502179171,"LOC729506","uncharacterized LOC729506",TRUE
+"1563637_at",0.70573152022539,0.177809629348374,-1.39176252475685,-5.03786174296421,-1.2615207662245,"LOC729652","uncharacterized LOC729652",TRUE
+"228977_at",0.982476966653206,0.915350841888396,-0.107511450427346,-5.93405522600537,-0.0745462655416276,"LOC729680","uncharacterized LOC729680",TRUE
+"236497_at",0.63743433712026,0.108215190071335,1.67387708532334,-4.66001753408394,0.496828145478988,"LOC729683","uncharacterized LOC729683",TRUE
+"236614_at",0.723649742218726,0.200157864219171,1.32046603863175,-5.12433590908293,0.539737935373013,"LOC729683","uncharacterized LOC729683",TRUE
+"1564426_x_at",0.634202341398092,0.105313744553792,1.68864516261592,-4.63875179802889,1.13761348172703,"LOC729732","uncharacterized LOC729732",TRUE
+"1568780_at",0.713330901550199,0.188028283593128,-1.35833479329745,-5.07887845449927,-1.1891257712606,"LOC729732","uncharacterized LOC729732",TRUE
+"217453_at",0.791211889207316,0.321413085476302,1.01424721274989,-5.4506911184893,0.329583246167055,"LOC729815","uncharacterized LOC729815",TRUE
+"1564235_at",0.913299709879835,0.636327455613302,0.479435111590246,-5.82834401082178,0.298397885167372,"LOC729866","uncharacterized LOC729866",TRUE
+"1560068_a_at",0.95297846015397,0.78458842991076,0.276682712105767,-5.90246581034995,0.111800514760234,"LOC729870","uncharacterized LOC729870",TRUE
+"230591_at",0.050114022740896,6.67003499526938e-05,-4.89502903370167,1.72709231844211,-3.02040920601275,"LOC729887","uncharacterized LOC729887",TRUE
+"231478_at",0.539609110035715,0.0445049327959855,-2.13014072098277,-3.94254830225087,-1.9358799954961,"LOC729966///PDE4C","uncharacterized LOC729966///phosphodiesterase 4C",TRUE
+"211818_s_at",0.852371612067119,0.458116765146375,0.755141319514119,-5.66569371762951,0.434191518288515,"LOC729966///PDE4C","uncharacterized LOC729966///phosphodiesterase 4C",TRUE
+"206791_s_at",0.941306621461417,0.737190420328004,-0.339822630628843,-5.88359370086658,-0.0922268494738487,"LOC729966///PDE4C","uncharacterized LOC729966///phosphodiesterase 4C",TRUE
+"206792_x_at",0.947062793209778,0.759650793476576,0.309742965678232,-5.89306203240745,0.11509991333021,"LOC729966///PDE4C","uncharacterized LOC729966///phosphodiesterase 4C",TRUE
+"230433_at",0.769847953580141,0.277721709676719,1.1128014181198,-5.353893230667,0.49499870524319,"LOC729970","hCG2028352-like",TRUE
+"235362_at",0.780216511409289,0.301612367355222,1.05764586338097,-5.40905681463027,0.834680565668569,"LOC729970","hCG2028352-like",TRUE
+"235691_at",0.860085676417428,0.479249559946612,0.719672897564362,-5.69051961671575,0.803048571553314,"LOC729970","hCG2028352-like",TRUE
+"230327_at",0.671498069723584,0.137616531785936,1.54043149486504,-4.84562290403903,1.06045555971653,"LOC730098","uncharacterized LOC730098",TRUE
+"213248_at",0.821745015752602,0.384710210192905,-0.886802116506387,-5.56373963257579,-0.518931824300451,"LOC730101","uncharacterized LOC730101",TRUE
+"241607_at",0.217184829141687,0.00261154591906604,3.39048079144469,-1.50178399683833,2.44207635327932,"LOC730102","quinone oxidoreductase-like protein 2 pseudogene",TRUE
+"239279_at",0.597879550155311,0.0752118228272908,1.86684874937038,-4.37133858892568,1.00469952350729,"LOC730102","quinone oxidoreductase-like protein 2 pseudogene",TRUE
+"1558128_at",0.434518658429923,0.0197410946052113,-2.51289204254667,-3.25837048762347,-2.21981435246433,"LOC730202","uncharacterized LOC730202",TRUE
+"218575_at",0.645740804644555,0.1169360714547,-1.63141652232484,-4.7203662729512,-0.519100682486673,"LOC730268///ANAPC1","anaphase-promoting complex subunit 1-like///anaphase promoting complex subunit 1",TRUE
+"229267_at",0.911012827592257,0.628719652922517,-0.490331846871617,-5.82325478976751,-0.165125429938223,"LOC730268///ANAPC1","anaphase-promoting complex subunit 1-like///anaphase promoting complex subunit 1",TRUE
+"230588_s_at",0.961778365989609,0.826684996502799,0.221560895083743,-5.91580217040468,0.0872465438995125,"LOC730268///LOC285074","anaphase-promoting complex subunit 1-like///anaphase promoting complex subunit 1 pseudogene",TRUE
+"239094_at",0.89967769475675,0.591187231775775,0.545015577025999,-5.79603177125026,0.192212872249344,"LOC730961","uncharacterized LOC730961",TRUE
+"233200_at",0.683019114815084,0.152151718117686,1.4830312675419,-4.9217124540896,0.817876510504214,"LOC731157","uncharacterized LOC731157",TRUE
+"233163_at",0.961539013416204,0.825711102158036,0.222827561888291,-5.91552865736335,0.129975595803526,"LOC731157","uncharacterized LOC731157",TRUE
+"203742_s_at",0.941400961503247,0.737953024261045,0.338796225983728,-5.8839310857821,0.0843940949187871,"LOC732360///TDG","G/T mismatch-specific thymine DNA glycosylase-like///thymine DNA glycosylase",TRUE
+"231354_at",0.493519901382617,0.0298678126741099,2.32110731067965,-3.60932699375743,1.30907466418321,"LOC780529","uncharacterized LOC780529",TRUE
+"239997_at",0.773156930607264,0.284057461679617,1.09785100318951,-5.36909252968098,0.769742964495784,"LOC780529","uncharacterized LOC780529",TRUE
+"220698_at",0.759458601980339,0.256977006619117,1.16356783975568,-5.30092771122376,0.947129001804543,"LOC79160","uncharacterized LOC79160",TRUE
+"220849_at",0.567651250567208,0.0576810747190665,2.00195055932486,-4.15604527657667,1.33974630564468,"LOC79999","uncharacterized LOC79999",TRUE
+"208107_s_at",0.686108994812404,0.154417536262216,-1.4744910762952,-4.93283493594312,-0.680288298675137,"LOC81691","exonuclease NEF-sp",TRUE
+"215215_s_at",0.715352956634026,0.19110096542472,-1.34856444443638,-5.09070985397477,-0.693843072957624,"LOC81691","exonuclease NEF-sp",TRUE
+"234912_at",0.677013732819214,0.14395112113553,1.514833552062,-4.87984053826285,0.896902059558523,"LOC81787","uncharacterized LOC81787",TRUE
+"234891_at",0.861962516141708,0.484456132911173,0.711076173329288,-5.69636594892883,0.324085298469112,"LOC81787","uncharacterized LOC81787",TRUE
+"224123_at",0.845487921422997,0.442586127924667,0.781836130360972,-5.64626401717145,0.238702114119206,"LOC84214","uncharacterized LOC84214",TRUE
+"1553623_at",0.932249295738588,0.700948638812775,-0.389055946622306,-5.86622710741169,-0.312116790947702,"LOC84843","uncharacterized LOC84843",TRUE
+"233830_at",0.697699759202153,0.168450959964619,1.423745779363,-4.99784656711513,0.43201913318954,"LOC90246","uncharacterized LOC90246",TRUE
+"233835_at",0.947778780715578,0.761887886751017,-0.30676334337698,-5.89395266571887,-0.414059038851554,"LOC90246","uncharacterized LOC90246",TRUE
+"232446_at",0.61760967235709,0.0880528461484778,-1.78444367772075,-4.49742988438793,-1.4641494110845,"LOC90768","uncharacterized LOC90768",TRUE
+"243688_at",0.929088231432081,0.687644653603258,0.407370876246302,-5.85917650191776,0.458684085547633,"LOC90768","uncharacterized LOC90768",TRUE
+"228515_at",0.987540154487264,0.941357290662709,-0.074403116197799,-5.93698754478259,-0.0575833788114775,"LOC90784///POLR1A","uncharacterized LOC90784///RNA polymerase I subunit A",TRUE
+"233321_x_at",0.875891766935648,0.523901426635238,-0.647594297867944,-5.73745840007113,-0.436320009432831,"LOC90834///BRD1","uncharacterized protein BC001742///bromodomain containing 1",TRUE
+"233418_at",0.614411830126793,0.0853807815514414,1.80069095947118,-4.47289425305446,0.713133186891159,"LOC91450","uncharacterized LOC91450",TRUE
+"234341_x_at",0.854763246850622,0.466526655043026,-0.740912770671528,-5.67578894876726,-0.36457809942515,"LOC91548","uncharacterized LOC91548",TRUE
+"232832_at",0.211717781026763,0.00247052481563923,3.41368144829688,-1.45300961228468,2.25172123395854,"LOC93429","uncharacterized LOC93429",TRUE
+"1564168_a_at",0.705559553212919,0.177349377938948,1.39330364172191,-5.03595081316504,0.583410327737886,"LOC93444","uncharacterized LOC93444",TRUE
+"234956_at",0.837609393049242,0.421764125383408,-0.818542672306607,-5.61851034487074,-0.242385856897494,"LOC93444","uncharacterized LOC93444",TRUE
+"234861_at",0.76159330462167,0.260755005954013,-1.15410309589516,-5.31096012869096,-0.99949667761257,"LOC93463","uncharacterized LOC93463",TRUE
+"225391_at",0.463701895754727,0.0238050164960901,-2.42691955498176,-3.41757740326678,-1.08136142229876,"LOC93622","Morf4 family associated protein 1 like 1 pseudogene",TRUE
+"236311_at",0.977874971442423,0.893241878769245,0.135753626663964,-5.93071135570822,0.0760551531322031,"LOH12CR2","loss of heterozygosity, 12, chromosomal region 2 (non-protein coding)",TRUE
+"209017_s_at",0.327689791987697,0.00758759850936393,-2.93722685445805,-2.43439659899073,-0.890656555606814,"LONP1","lon peptidase 1, mitochondrial",TRUE
+"226038_at",0.615005518451136,0.0856677097123704,-1.79892545276602,-4.47556823391273,-0.860846534138061,"LONRF1","LON peptidase N-terminal domain and ring finger 1",TRUE
+"236556_s_at",0.895457620469779,0.574523898586738,-0.569832937751758,-5.78275501832729,-0.460406503835974,"LONRF1","LON peptidase N-terminal domain and ring finger 1",TRUE
+"215322_at",0.979794616772313,0.903581758944631,0.122532731598692,-5.93237322812673,0.0340942420386883,"LONRF1","LON peptidase N-terminal domain and ring finger 1",TRUE
+"225996_at",0.402463840838386,0.0147682708618574,-2.64408626989493,-3.00999142629634,-5.32104279222524,"LONRF2","LON peptidase N-terminal domain and ring finger 2",TRUE
+"235977_at",0.971216837324271,0.863018044276203,0.174550424817133,-5.92485460020894,0.213454319398811,"LONRF2","LON peptidase N-terminal domain and ring finger 2",TRUE
+"220009_at",0.855772184009104,0.469095762871428,0.736596598202319,-5.67881530657682,0.442484931196274,"LONRF3","LON peptidase N-terminal domain and ring finger 3",TRUE
+"207720_at",0.545412722791443,0.0470635674175008,2.1028001755771,-3.98880147803783,1.01388002217786,"LOR","loricrin",TRUE
+"213640_s_at",0.768852835478002,0.272438574224678,1.12545889949972,-5.34088263275647,1.56089518645042,"LOX","lysyl oxidase",TRUE
+"215446_s_at",0.810417059188012,0.354528500481166,0.945646105661213,-5.51326935587967,1.43460267778266,"LOX","lysyl oxidase",TRUE
+"204298_s_at",0.816800680706682,0.368831065572676,0.91736231383704,-5.5379011899916,1.19410149539292,"LOX","lysyl oxidase",TRUE
+"241117_at",0.970371486885203,0.859020582290456,-0.179701032236771,-5.92396724210726,-0.113324226147493,"LOXHD1","lipoxygenase homology domains 1",TRUE
+"203570_at",0.970540753946729,0.85972511156249,0.178792910655223,-5.9241255632715,0.254811540471529,"LOXL1","lysyl oxidase like 1",TRUE
+"232752_at",0.967701855457407,0.848185885736237,0.19368668579963,-5.92142803589523,0.180683362712399,"LOXL1-AS1","LOXL1 antisense RNA 1",TRUE
+"202998_s_at",0.760905446901853,0.259952708240821,1.1561045018896,-5.30884467943834,1.63736210925878,"LOXL2","lysyl oxidase like 2",TRUE
+"202999_s_at",0.767965891104819,0.270764761333959,1.12950645234284,-5.33669470150379,0.72425716613611,"LOXL2","lysyl oxidase like 2",TRUE
+"202997_s_at",0.768205466878316,0.271341270715209,1.1281102959983,-5.33814078067138,1.65245105384759,"LOXL2","lysyl oxidase like 2",TRUE
+"228808_s_at",0.807051198331174,0.348238717348497,0.958327793816872,-5.5020023865271,0.415923375511427,"LOXL2","lysyl oxidase like 2",TRUE
+"228253_at",0.678611044120554,0.146175882244251,1.50606247396945,-4.89145991994879,0.492918097781632,"LOXL3","lysyl oxidase like 3",TRUE
+"227145_at",0.78065889313777,0.302312016981871,1.05607857969544,-5.41058767960281,0.831333450267545,"LOXL4","lysyl oxidase like 4",TRUE
+"1570219_at",0.791646964605038,0.322134875173533,-1.01270113158155,-5.45214528640595,-0.496100929922203,"LOXL4","lysyl oxidase like 4",TRUE
+"207584_at",0.636147339487472,0.107383105634451,1.67807768780077,-4.65398313938866,1.12386780944267,"LPA","lipoprotein(a)",TRUE
+"207762_at",0.615637099066718,0.08584188728625,1.79785620438437,-4.47718675861169,1.14573020554264,"LPAL2","lipoprotein(a) like 2, pseudogene",TRUE
+"210909_x_at",0.70573152022539,0.17785777773884,1.39160148697795,-5.0380613230712,0.906418168865703,"LPAL2","lipoprotein(a) like 2, pseudogene",TRUE
+"204037_at",0.544172907409316,0.0464764419469807,2.10895356849718,-3.97842473900251,1.50861978099127,"LPAR1","lysophosphatidic acid receptor 1",TRUE
+"204036_at",0.580630437263151,0.0630388860250751,1.95720486341196,-4.22849195705845,2.6678107062131,"LPAR1","lysophosphatidic acid receptor 1",TRUE
+"204038_s_at",0.71611852101483,0.191796114682359,1.3463712142565,-5.0933559217116,0.997603953723564,"LPAR1","lysophosphatidic acid receptor 1",TRUE
+"206722_s_at",0.839466826665106,0.425856269112281,0.81124137812219,-5.62412608182068,0.390525812872054,"LPAR2","lysophosphatidic acid receptor 2",TRUE
+"206723_s_at",0.939976205834042,0.730199799643603,0.349248981407639,-5.8804480234352,0.153531157582002,"LPAR2","lysophosphatidic acid receptor 2",TRUE
+"220816_at",0.657737952475465,0.126422828396244,1.5881442427315,-4.78063754861111,1.04476487150375,"LPAR3","lysophosphatidic acid receptor 3",TRUE
+"231192_at",0.680708651141727,0.148656274140417,1.49641134057024,-4.90418269048265,2.44912265474078,"LPAR3","lysophosphatidic acid receptor 3",TRUE
+"206960_at",0.868039927215454,0.501775489048337,-0.682856721851895,-5.71508599024868,-0.55024215546861,"LPAR4","lysophosphatidic acid receptor 4",TRUE
+"230252_at",0.104106354532609,0.00048554404034413,4.08406528832202,-0.0192640012991312,4.15276541302276,"LPAR5","lysophosphatidic acid receptor 5",TRUE
+"231788_at",0.153726668922469,0.00115304467508567,3.72953150837096,-0.782136904115307,1.959001457505,"LPAR5","lysophosphatidic acid receptor 5",TRUE
+"1557763_at",0.931582451098271,0.697802065587528,0.393375227949927,-5.86459311727987,0.33515112414049,"LPAR6","lysophosphatidic acid receptor 6",TRUE
+"218589_at",0.932091525948902,0.700664278000083,-0.389445976160694,-5.86608028884973,-0.323665583459576,"LPAR6","lysophosphatidic acid receptor 6",TRUE
+"201818_at",0.821555706120251,0.3840428580384,-0.888069597431897,-5.56268408552791,-0.523990624704339,"LPCAT1","lysophosphatidylcholine acyltransferase 1",TRUE
+"239598_s_at",0.468982266038461,0.0251316083029629,2.401795884285,-3.4635365076358,1.1465363448162,"LPCAT2","lysophosphatidylcholine acyltransferase 2",TRUE
+"227889_at",0.562912272082653,0.0555696610639396,2.02060350545305,-4.12552056311694,1.85673449694147,"LPCAT2","lysophosphatidylcholine acyltransferase 2",TRUE
+"222833_at",0.620223198657182,0.0902172942284366,1.77159148640269,-4.51672349015925,2.43482348313222,"LPCAT2","lysophosphatidylcholine acyltransferase 2",TRUE
+"229791_at",0.637907046898546,0.10920096037357,1.66893583328508,-4.66710122295602,0.722025742445036,"LPCAT2","lysophosphatidylcholine acyltransferase 2",TRUE
+"202793_at",0.792610942614642,0.324147794730012,-1.00840215722868,-5.45617813157736,-0.420376423760965,"LPCAT3","lysophosphatidylcholine acyltransferase 3",TRUE
+"213615_at",0.855207394590633,0.467513375709546,-0.739253391384604,-5.6769544353145,-0.248931338081547,"LPCAT3","lysophosphatidylcholine acyltransferase 3",TRUE
+"215409_at",0.677509122383198,0.144905168225513,1.51105874557023,-4.88484777925465,1.39293551075208,"LPCAT4","lysophosphatidylcholine acyltransferase 4",TRUE
+"213078_x_at",0.736715608368239,0.222166748070883,1.25609087696652,-5.19910984731156,0.551449802522608,"LPCAT4","lysophosphatidylcholine acyltransferase 4",TRUE
+"40472_at",0.773234064853267,0.284390455257806,1.09707195457167,-5.36987953859985,0.606129491193188,"LPCAT4","lysophosphatidylcholine acyltransferase 4",TRUE
+"239608_at",0.774230543658252,0.287140448524472,1.09066333181401,-5.37633477247169,0.705981965165183,"LPCAT4","lysophosphatidylcholine acyltransferase 4",TRUE
+"239609_s_at",0.990810941805126,0.95640309058935,0.0552898500535281,-5.93819465426137,0.0329369055928463,"LPCAT4","lysophosphatidylcholine acyltransferase 4",TRUE
+"202651_at",0.881970070870254,0.539076672691478,-0.623880716995703,-5.75186292529861,-0.241174489772185,"LPGAT1","lysophosphatidylglycerol acyltransferase 1",TRUE
+"227476_at",0.91960407224049,0.658397830962122,0.448148124313392,-5.84233391206277,0.168586730415948,"LPGAT1","lysophosphatidylglycerol acyltransferase 1",TRUE
+"1555058_a_at",0.993919358691598,0.971499120832599,0.0361339574730769,-5.93904756050762,0.0156127643135484,"LPGAT1","lysophosphatidylglycerol acyltransferase 1",TRUE
+"212272_at",0.69114521567028,0.160798288207503,-1.45097545748406,-4.96319200706057,-0.769027210974549,"LPIN1","lipin 1",TRUE
+"212274_at",0.736223289546449,0.221691749223389,-1.25742717236043,-5.19759011683492,-0.728582706432325,"LPIN1","lipin 1",TRUE
+"212276_at",0.816800680706682,0.368036283486084,-0.918914589976635,-5.53656719354094,-0.479606474921637,"LPIN1","lipin 1",TRUE
+"202460_s_at",0.954577684533304,0.792798489265002,-0.265868861611248,-5.90531333829834,-0.169363448572557,"LPIN2","lipin 2",TRUE
+"202459_s_at",0.984244246588495,0.923277530137204,0.0974088274483271,-5.93506304862373,0.0718528930975104,"LPIN2","lipin 2",TRUE
+"232966_at",0.774209477315394,0.285937751077248,-1.09346063597373,-5.37352126367725,-0.585669006141522,"LPIN3","lipin 3",TRUE
+"203549_s_at",0.153849541764532,0.00116213737080479,3.72629645216525,-0.789061454488343,1.51586877763024,"LPL","lipoprotein lipase",TRUE
+"203548_s_at",0.308621629697291,0.00634397874536536,3.01448448496241,-2.27862479677966,2.70173946679428,"LPL","lipoprotein lipase",TRUE
+"210682_at",0.893879525734626,0.569467062467096,0.577435632193645,-5.77857308377355,0.250751558060399,"LPO","lactoperoxidase",TRUE
+"202822_at",0.576100679385983,0.0611531217564966,1.97255592158476,-4.20376228498277,0.81537556769528,"LPP","LIM domain containing preferred translocation partner in lipoma",TRUE
+"224811_at",0.697172073261335,0.166883166717699,1.42924204607568,-4.99089484500083,0.614124511079618,"LPP","LIM domain containing preferred translocation partner in lipoma",TRUE
+"1558469_at",0.707297203155401,0.178806802780319,1.38843441940562,-5.04198250268631,0.866623029277286,"LPP","LIM domain containing preferred translocation partner in lipoma",TRUE
+"202821_s_at",0.716749536957327,0.192762032689472,1.34333404339801,-5.09701422021913,0.495604589923428,"LPP","LIM domain containing preferred translocation partner in lipoma",TRUE
+"241879_at",0.732963666545614,0.217402318799638,1.2695949551749,-5.18368840949654,0.64560832478616,"LPP","LIM domain containing preferred translocation partner in lipoma",TRUE
+"235000_at",0.757479140651,0.253567184061677,1.17219924667088,-5.29171602064661,0.461439412292908,"LPP","LIM domain containing preferred translocation partner in lipoma",TRUE
+"214902_x_at",0.847644062908097,0.446549273373369,0.774970783100512,-5.65132178860535,0.282415526839051,"LPP","LIM domain containing preferred translocation partner in lipoma",TRUE
+"230996_at",0.942502815705589,0.742158917365789,0.333142053955207,-5.8857715456818,0.138789597384513,"LPP","LIM domain containing preferred translocation partner in lipoma",TRUE
+"1556827_at",0.790252299055943,0.319815502902805,1.01767789186743,-5.44745722252106,0.628419120093576,"LPP-AS2","LPP antisense RNA 2",TRUE
+"216250_s_at",0.323364875535351,0.00732782955259808,2.95230635201162,-2.40411276229682,1.63603818347242,"LPXN","leupaxin",TRUE
+"242778_at",0.722192678020526,0.198567389036642,-1.32532732056557,-5.11856090615098,-0.457926667169711,"LPXN","leupaxin",TRUE
+"220317_at",0.545080135838504,0.0468664237508332,2.10485861498095,-3.98533239967026,1.6272342412067,"LRAT","lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)",TRUE
+"214109_at",0.772430642757484,0.282827987544689,-1.10073313320614,-5.36617663155317,-0.519373587776993,"LRBA","LPS responsive beige-like anchor protein",TRUE
+"212692_s_at",0.845588139978284,0.443154687936676,-0.780848916812846,-5.64699389669758,-0.403652119067612,"LRBA","LPS responsive beige-like anchor protein",TRUE
+"214936_at",0.871660802911361,0.51317216529883,0.664587889484956,-5.7268185905128,0.351573418623624,"LRCH1","leucine rich repeats and calponin homology domain containing 1",TRUE
+"226795_at",0.903135001920348,0.603130650665161,0.527439263642246,-5.80508717777633,0.190142736528934,"LRCH1","leucine rich repeats and calponin homology domain containing 1",TRUE
+"235012_at",0.926443878433296,0.680391906622964,0.417414992294708,-5.85517437837751,0.163481963614068,"LRCH1","leucine rich repeats and calponin homology domain containing 1",TRUE
+"227688_at",0.123760100530367,0.000711693349013773,3.92766742293539,-0.356589898546268,3.05277355122772,"LRCH2","leucine rich repeats and calponin homology domain containing 2",TRUE
+"240926_at",0.578925607036084,0.0618580335895539,1.96676923682474,-4.21309971974964,0.596613452263225,"LRCH3","leucine rich repeats and calponin homology domain containing 3",TRUE
+"1553668_at",0.645740804644555,0.116852701414602,1.63180963068978,-4.71981300254805,0.459477230703764,"LRCH3","leucine rich repeats and calponin homology domain containing 3",TRUE
+"1559490_at",0.664123571602771,0.132145207510218,1.56333445703506,-4.81462329781497,1.00608661131745,"LRCH3","leucine rich repeats and calponin homology domain containing 3",TRUE
+"214739_at",0.776936981479994,0.295352883820628,1.07178435322685,-5.3951549347836,0.347025809168009,"LRCH3","leucine rich repeats and calponin homology domain containing 3",TRUE
+"229387_at",0.874834820370747,0.521588153198396,0.65124183625376,-5.73519693817876,0.545114918642454,"LRCH3","leucine rich repeats and calponin homology domain containing 3",TRUE
+"228119_at",0.877948371309952,0.529636550527396,0.638589064209059,-5.74298936314067,0.495410911523676,"LRCH3","leucine rich repeats and calponin homology domain containing 3",TRUE
+"235347_at",0.93613089056626,0.714472615678716,0.370575958273016,-5.87301723367737,0.152074304855221,"LRCH3","leucine rich repeats and calponin homology domain containing 3",TRUE
+"221956_at",0.615821255316333,0.0866979759315783,-1.79262787772127,-4.4850908287139,-0.838350232260565,"LRCH4","leucine rich repeats and calponin homology domain containing 4",TRUE
+"90610_at",0.680368302780913,0.14791451860966,-1.49928361761526,-4.90040311736016,-0.497214979508897,"LRCH4","leucine rich repeats and calponin homology domain containing 4",TRUE
+"222017_x_at",0.85069818933195,0.453769563782455,0.762557625188687,-5.66035976692193,0.527200775227289,"LRCH4","leucine rich repeats and calponin homology domain containing 4",TRUE
+"232486_at",0.771527793162888,0.280794397132669,-1.10552025849129,-5.36131840625612,-0.452819480850666,"LRFN1","leucine rich repeat and fibronectin type III domain containing 1",TRUE
+"232697_at",0.94315816834905,0.74459038278223,-0.329878382275799,-5.88681993709106,-0.225161194536818,"LRFN2","leucine rich repeat and fibronectin type III domain containing 2",TRUE
+"219346_at",0.824027323790285,0.39140314087903,-0.874169029481223,-5.57418392747205,-0.501186887607076,"LRFN3","leucine rich repeat and fibronectin type III domain containing 3",TRUE
+"238092_at",0.771008055264122,0.279598328342123,1.10834759428082,-5.35844028461036,0.76320407438863,"LRFN4","leucine rich repeat and fibronectin type III domain containing 4",TRUE
+"219491_at",0.78226567430527,0.304450499987263,1.05130409383048,-5.4152386610331,0.699848663808373,"LRFN4","leucine rich repeat and fibronectin type III domain containing 4",TRUE
+"240334_at",0.687659256779784,0.156715310033709,1.46593371830568,-4.94392768495702,0.876210913121705,"LRFN5","leucine rich repeat and fibronectin type III domain containing 5",TRUE
+"230644_at",0.83872852514497,0.423986977746733,0.814571142214467,-5.62157087065391,0.6355453107886,"LRFN5","leucine rich repeat and fibronectin type III domain containing 5",TRUE
+"228648_at",0.752155597823425,0.24531425905051,1.19345411634417,-5.26877876980504,1.23814355794608,"LRG1","leucine rich alpha-2-glycoprotein 1",TRUE
+"244710_at",0.728385463227073,0.209610940965116,1.29217742558166,-5.15758532079736,0.45370482379315,"LRGUK","leucine rich repeats and guanylate kinase domain containing",TRUE
+"220235_s_at",0.516444287133032,0.0363653105156831,-2.22771228991694,-3.77445345766011,-0.862344299865278,"LRIF1","ligand dependent nuclear receptor interacting factor 1",TRUE
+"211596_s_at",0.642592458809121,0.112706317958597,-1.65166463600943,-4.69173561185821,-1.56282572496189,"LRIG1","leucine rich repeats and immunoglobulin like domains 1",TRUE
+"240140_s_at",0.650298942402444,0.120465788538028,-1.61498476622474,-4.74340076448504,-0.639298874395295,"LRIG1","leucine rich repeats and immunoglobulin like domains 1",TRUE
+"238339_x_at",0.921727601757524,0.666037751993347,-0.437424326031441,-5.84691607301,-0.29352247435691,"LRIG1","leucine rich repeats and immunoglobulin like domains 1",TRUE
+"236173_s_at",0.952493660404718,0.782447192746548,0.279508531194521,-5.90170313888439,0.190104167935758,"LRIG1","leucine rich repeats and immunoglobulin like domains 1",TRUE
+"238653_at",0.732207869755374,0.215919295547616,-1.27384472134609,-5.17880608330734,-0.430253718974157,"LRIG2","leucine rich repeats and immunoglobulin like domains 2",TRUE
+"205953_at",0.8288884913487,0.399731190697598,0.858643698324817,-5.58682861825571,0.227215964060109,"LRIG2","leucine rich repeats and immunoglobulin like domains 2",TRUE
+"242165_at",0.939610295972262,0.729198382954878,-0.350601945009083,-5.87998954344529,-0.200846044653869,"LRIG2","leucine rich repeats and immunoglobulin like domains 2",TRUE
+"242164_s_at",0.986145735582101,0.932238097476944,-0.0860009545179744,-5.93608172383394,-0.0338331401785616,"LRIG2","leucine rich repeats and immunoglobulin like domains 2",TRUE
+"226908_at",0.952613441433926,0.782896491658351,0.278915393508269,-5.90186386098175,0.163179046005577,"LRIG3","leucine rich repeats and immunoglobulin like domains 3",TRUE
+"211353_at",0.885312914741353,0.546531822034924,0.612362426871002,-5.75867285797607,0.163004806713276,"LRIT1","leucine rich repeat, Ig-like and transmembrane domains 1",TRUE
+"240718_at",0.63381727351094,0.104760982180491,-1.69149768586047,-4.63462796432709,-0.992379006486803,"LRMP","lymphoid restricted membrane protein",TRUE
+"35974_at",0.82750481665844,0.396305527990577,0.865004367997462,-5.5816736165878,0.756164239778808,"LRMP","lymphoid restricted membrane protein",TRUE
+"204674_at",0.924755635819804,0.674433122602921,-0.425699893534521,-5.85180109360601,-0.287038300907374,"LRMP","lymphoid restricted membrane protein",TRUE
+"200785_s_at",0.747487330197396,0.239285426602358,1.20932216044898,-5.25142093156359,0.51697726910875,"LRP1","LDL receptor related protein 1",TRUE
+"1555353_at",0.782921408555092,0.305367702797645,1.04926359381309,-5.41722060473357,0.88981071727266,"LRP1","LDL receptor related protein 1",TRUE
+"200784_s_at",0.912241810302154,0.632017463097569,0.485601042723422,-5.82547800131176,0.311960477803809,"LRP1","LDL receptor related protein 1",TRUE
+"1569042_at",0.962555471240652,0.829297730583247,0.218164544280725,-5.91652788940036,0.0811277183796593,"LRP1","LDL receptor related protein 1",TRUE
+"201412_at",0.774389765062463,0.290687086135448,-1.08246322927182,-5.38454535742654,-0.429713493358344,"LRP10","LDL receptor related protein 10",TRUE
+"227252_at",0.797508506396963,0.331069207145028,-0.993760236336914,-5.46979687442653,-0.584660387192782,"LRP10","LDL receptor related protein 10",TRUE
+"231861_at",0.937203701144735,0.721195466522581,-0.36143852978835,-5.87625415597578,-0.151706419282297,"LRP10","LDL receptor related protein 10",TRUE
+"225060_at",0.813065886130395,0.362924059460673,0.928952986167023,-5.52789025514888,0.42646987862337,"LRP11","LDL receptor related protein 11",TRUE
+"220254_at",0.955904644595647,0.800435965981132,-0.255838212111834,-5.90785383254532,-0.369908646538078,"LRP12","LDL receptor related protein 12",TRUE
+"219631_at",0.956762870061999,0.804327877896545,0.250737149194565,-5.90910855816097,0.302125272236299,"LRP12","LDL receptor related protein 12",TRUE
+"220253_s_at",0.998347572104896,0.992934783296969,-0.00895550466834744,-5.93964441784337,-0.0114019048608593,"LRP12","LDL receptor related protein 12",TRUE
+"219643_at",0.873405654736848,0.51866284667543,0.655867185599516,-5.73231170759417,0.805161972409872,"LRP1B","LDL receptor related protein 1B",TRUE
+"230863_at",0.905129154898374,0.610769730970656,-0.516285243591799,-5.81068390090596,-0.736650570334587,"LRP2","LDL receptor related protein 2",TRUE
+"205710_at",0.943988850936011,0.749785130712219,-0.322917826985696,-5.88902175536798,-0.390181167389507,"LRP2","LDL receptor related protein 2",TRUE
+"207797_s_at",0.844169896707408,0.440779313263197,0.78497853414396,-5.64393494862668,0.546177119254105,"LRP2BP","LRP2 binding protein",TRUE
+"204381_at",0.00781390238119631,2.85830905576454e-06,-6.21642281295994,4.4516216774255,-3.35170638725984,"LRP3","LDL receptor related protein 3",TRUE
+"228525_at",0.34079367596048,0.00849568871210123,-2.88813579566767,-2.53256296932104,-1.68075247157199,"LRP3","LDL receptor related protein 3",TRUE
+"212850_s_at",0.784925710185113,0.310131736194961,1.03873429688175,-5.42739269620407,1.15955061155476,"LRP4","LDL receptor related protein 4",TRUE
+"229591_at",0.528176582660474,0.0408243023504384,-2.1720675731474,-3.87088856814039,-1.25012156602034,"LRP5","LDL receptor related protein 5",TRUE
+"209468_at",0.786851686785014,0.31276904817373,1.03295444930766,-5.4329371856334,0.494628251447219,"LRP5","LDL receptor related protein 5",TRUE
+"214873_at",0.656973066284686,0.124978086189795,-1.59455532207992,-4.77178735569856,-0.907954511988579,"LRP5L","LDL receptor related protein 5 like",TRUE
+"205606_at",0.874834820370747,0.521559062914859,0.651287761938879,-5.73516838667692,0.586484198624058,"LRP6","LDL receptor related protein 6",TRUE
+"225745_at",0.961876388239691,0.826854687907989,0.221340228966206,-5.91584966040979,0.102264997644701,"LRP6","LDL receptor related protein 6",TRUE
+"34697_at",0.982243328340126,0.914775394224961,-0.108245296234645,-5.93397815147148,-0.0405444437815827,"LRP6","LDL receptor related protein 6",TRUE
+"205282_at",0.910292496128599,0.627181478258659,-0.492542282617627,-5.82220879065008,-0.189971469158845,"LRP8","LDL receptor related protein 8",TRUE
+"208433_s_at",0.962555471240652,0.829723717382169,0.217611044449111,-5.91664510161397,0.095040092035207,"LRP8","LDL receptor related protein 8",TRUE
+"228955_at",0.976364796498418,0.88582671660364,-0.14525002571387,-5.92941285361895,-0.0760894706871209,"LRP8","LDL receptor related protein 8",TRUE
+"201186_at",0.585036027492332,0.0655712433491858,-1.93721586477223,-4.26049517454343,-0.583277932835605,"LRPAP1","LDL receptor related protein associated protein 1",TRUE
+"242705_x_at",0.977415153466377,0.891800391359304,0.137598672280198,-5.93046592765487,0.0578478218261598,"LRPAP1","LDL receptor related protein associated protein 1",TRUE
+"235505_s_at",0.997901456792957,0.990345330535759,0.0122379098601362,-5.93961053530236,0.0064449607260233,"LRPAP1","LDL receptor related protein associated protein 1",TRUE
+"1570344_at",0.803583569469174,0.342081442499312,0.970893946220581,-5.49070270927346,0.441430010331332,"LRPPRC","leucine rich pentatricopeptide repeat containing",TRUE
+"1557360_at",0.85069818933195,0.453737625609624,0.762612269447649,-5.66032028278372,0.262347889063681,"LRPPRC","leucine rich pentatricopeptide repeat containing",TRUE
+"230194_at",0.86880806912978,0.505145987395655,0.677429759607392,-5.71860307443795,0.315340706781537,"LRPPRC","leucine rich pentatricopeptide repeat containing",TRUE
+"211971_s_at",0.869082033398093,0.505756051452719,0.676449657544088,-5.71923539349988,0.185279947267224,"LRPPRC","leucine rich pentatricopeptide repeat containing",TRUE
+"211615_s_at",0.892746695408886,0.565580384203856,0.583302478092964,-5.77530928615236,0.190650527824854,"LRPPRC","leucine rich pentatricopeptide repeat containing",TRUE
+"235113_at",0.623418029554799,0.0940127874049987,-1.74968076410435,-4.54937947001001,-0.559816650292095,"LRR1","leucine rich repeat protein 1",TRUE
+"242154_x_at",0.643852971767472,0.114750780808492,-1.6417993262915,-4.70571890036505,-0.62290657070892,"LRR1","leucine rich repeat protein 1",TRUE
+"207790_at",0.51531387545335,0.0356205798956171,2.23760537850808,-3.75715316228987,0.855498927000138,"LRRC1","leucine rich repeat containing 1",TRUE
+"218816_at",0.847743900645108,0.447044392197526,0.774115702193769,-5.65194878839939,0.300346459326754,"LRRC1","leucine rich repeat containing 1",TRUE
+"236666_s_at",0.996459692848816,0.982608584178215,-0.0220460209419691,-5.9394467576705,-0.0279145078296459,"LRRC10B","leucine rich repeat containing 10B",TRUE
+"32062_at",0.919254462391029,0.656044315305746,0.451462368649186,-5.8408957523173,0.296625542253995,"LRRC14","leucine rich repeat containing 14",TRUE
+"203495_at",0.942303845415102,0.740837360389266,0.334917480877621,-5.88519693572678,0.179578112999163,"LRRC14","leucine rich repeat containing 14",TRUE
+"1552960_at",0.639705117673934,0.110225827411762,1.66383840450656,-4.67439212547146,1.18133502150965,"LRRC15","leucine rich repeat containing 15",TRUE
+"213909_at",0.95442332217412,0.790495001963537,-0.268899567843098,-5.9045266539425,-0.167578005795322,"LRRC15","leucine rich repeat containing 15",TRUE
+"232924_at",0.464344196869063,0.0238964040192133,2.42514774568641,-3.42082717206059,1.21804915553484,"LRRC17","leucine rich repeat containing 17",TRUE
+"205381_at",0.689168483917391,0.15828490693025,1.46014650661499,-4.95139989177965,0.96256116838835,"LRRC17","leucine rich repeat containing 17",TRUE
+"1554331_a_at",0.969859842767097,0.85584804080543,-0.183792291903315,-5.92324405996508,-0.118510497479994,"LRRC18","leucine rich repeat containing 18",TRUE
+"220376_at",0.820291269575398,0.378842057841105,0.897997110076834,-5.55436826684551,0.566552113166424,"LRRC19","leucine rich repeat containing 19",TRUE
+"219949_at",0.490107603095446,0.0292630790501519,2.33072447110703,-3.59209905713035,2.5097037744238,"LRRC2","leucine rich repeat containing 2",TRUE
+"231781_s_at",0.640067422642767,0.110790514630509,1.66104686751129,-4.67837769564066,1.80027474643483,"LRRC2","leucine rich repeat containing 2",TRUE
+"236731_at",0.922066204645018,0.667344888596397,0.435594804979714,-5.84768693021959,0.29518620356383,"LRRC2-AS1","LRRC2 antisense RNA 1",TRUE
+"218550_s_at",0.774230543658252,0.288254911673625,1.08807878319813,-5.37892858644301,0.489056512493098,"LRRC20","leucine rich repeat containing 20",TRUE
+"206076_at",0.790240875783718,0.319557782495936,-1.0182324465514,-5.44693354967752,-0.683535988806891,"LRRC23","leucine rich repeat containing 23",TRUE
+"1559502_s_at",0.837368340567858,0.421151146134811,0.81964017653348,-5.61766212978065,0.383046029781375,"LRRC25","leucine rich repeat containing 25",TRUE
+"1558484_s_at",0.74377417656369,0.234579641530211,1.22191858100609,-5.23750038540237,0.436819250191512,"LRRC27","leucine rich repeat containing 27",TRUE
+"228884_at",0.884769004468037,0.544572141469487,-0.61538201374486,-5.75689942456592,-0.2213707943264,"LRRC27","leucine rich repeat containing 27",TRUE
+"228886_at",0.968035667633768,0.849266754907112,-0.192289747828743,-5.92169018244661,-0.0779533291767764,"LRRC27","leucine rich repeat containing 27",TRUE
+"1558483_at",0.998347572104896,0.991962216234369,-0.0101883224503834,-5.93963292279022,-0.00439522751129129,"LRRC27","leucine rich repeat containing 27",TRUE
+"227423_at",0.915353407558177,0.642974696756362,0.469962210025313,-5.83267733624626,0.168812324610258,"LRRC28","leucine rich repeat containing 28",TRUE
+"1553940_a_at",0.954569345112903,0.791712045593687,-0.267297980564896,-5.90494348339219,-0.127280339601208,"LRRC28","leucine rich repeat containing 28",TRUE
+"238897_at",0.954723352940649,0.794111776108977,0.264142105455971,-5.90575759423743,0.235922436701111,"LRRC28","leucine rich repeat containing 28",TRUE
+"239471_at",0.986421906591669,0.936680631392035,-0.0803495074050259,-5.93653946921921,-0.0283711218979947,"LRRC28","leucine rich repeat containing 28",TRUE
+"232545_at",0.920029531612896,0.659540661149363,-0.446540618791475,-5.84302771862988,-0.273434862111757,"LRRC29","leucine rich repeat containing 29",TRUE
+"221017_s_at",0.861357981297227,0.481817455210105,0.715426220905808,-5.69341599006343,0.363581143730327,"LRRC3","leucine rich repeat containing 3",TRUE
+"232536_at",0.91766569619844,0.650749599872079,0.458937322972873,-5.83761398947765,0.336760767490158,"LRRC3///LRRC3DN","leucine rich repeat containing 3///LRRC3 downstream neighbor (non-protein coding)",TRUE
+"220622_at",0.748062459902618,0.239932866210512,-1.20760376476893,-5.25331027238235,-2.03881757967285,"LRRC31","leucine rich repeat containing 31",TRUE
+"203835_at",0.978210818668419,0.894371844799554,0.134307653493632,-5.930901387507,0.0759932549684703,"LRRC32","leucine rich repeat containing 32",TRUE
+"236917_at",0.212348514754308,0.00251567443410172,3.40611576406907,-1.46892377768722,3.42486006922647,"LRRC34","leucine rich repeat containing 34",TRUE
+"236918_s_at",0.598790786356002,0.0757558979505318,1.86311773815673,-4.37713532889358,2.1263298839948,"LRRC34","leucine rich repeat containing 34",TRUE
+"220003_at",0.863559206655094,0.488626156423632,-0.704229473406985,-5.7009742820709,-0.73665037810032,"LRRC36","leucine rich repeat containing 36",TRUE
+"221740_x_at",0.913468969775679,0.637112624202443,-0.478313873637512,-5.82886132891066,-0.181952273122944,"LRRC37A2","leucine rich repeat containing 37 member A2",TRUE
+"224686_x_at",0.96287357728432,0.831501996303277,-0.215301211892199,-5.91713104516256,-0.0859896406494229,"LRRC37A2","leucine rich repeat containing 37 member A2",TRUE
+"242432_at",0.975398143273847,0.881598477316148,0.150671090151311,-5.92863232725467,0.130407513454434,"LRRC37A2","leucine rich repeat containing 37 member A2",TRUE
+"220219_s_at",0.805746717966166,0.345856746675642,0.963170974499764,-5.49766325573004,0.317773595658593,"LRRC37A2///LRRC37A3///LRRC37A4P///LRRC37A","leucine rich repeat containing 37 member A2///leucine rich repeat containing 37 member A3///leucine rich repeat containing 37 member A4, pseudogene///leucine rich repeat containing 37A",TRUE
+"220220_at",0.62986301194198,0.101019766844768,1.71114740224166,-4.60607863066984,1.51144886541511,"LRRC37A2///LRRC37A4P","leucine rich repeat containing 37 member A2///leucine rich repeat containing 37 member A4, pseudogene",TRUE
+"244478_at",0.766550448794594,0.267775202568387,1.1367815465504,-5.32913392257139,0.906179833717169,"LRRC37A3","leucine rich repeat containing 37 member A3",TRUE
+"206088_at",0.931370027472813,0.695832953932007,0.396082089845206,-5.86356004862835,0.183709655218752,"LRRC37A3","leucine rich repeat containing 37 member A3",TRUE
+"229962_at",0.986455005400648,0.937200843081617,0.0796879134011074,-5.93659102345393,0.0373686785131824,"LRRC37A3","leucine rich repeat containing 37 member A3",TRUE
+"229821_at",0.562643595171948,0.0552049384119311,2.02388926911091,-4.12012405394282,1.59220519422452,"LRRC37A4P","leucine rich repeat containing 37 member A4, pseudogene",TRUE
+"1562803_at",0.937271400689562,0.721969450224391,-0.360388586900401,-5.87662098608603,-0.299179766302147,"LRRC37A5P","leucine rich repeat containing 37 member A5, pseudogene",TRUE
+"1569761_x_at",0.917412255609003,0.6503406791104,-0.459515728076646,-5.83735784823521,-0.287176719807418,"LRRC37A7P","leucine rich repeat containing 37 member A7, pseudogene",TRUE
+"1569760_at",0.933448396773721,0.705599036654379,-0.382686115399845,-5.86860437548895,-0.292635417056196,"LRRC37A7P","leucine rich repeat containing 37 member A7, pseudogene",TRUE
+"1563750_at",0.961212424803935,0.823190292945587,0.226107915267348,-5.91481311363717,0.224936750339276,"LRRC37A8P","leucine rich repeat containing 37 member A8, pseudogene",TRUE
+"229231_at",0.908173262011196,0.618720545709283,0.504746055353475,-5.81635116239901,0.151906245620506,"LRRC37B","leucine rich repeat containing 37B",TRUE
+"216149_at",0.93919895813272,0.727993056556997,0.352231286074495,-5.87943508214399,0.288795892682812,"LRRC37BP1","leucine rich repeat containing 37B pseudogene 1",TRUE
+"1558375_at",0.803135302652907,0.341089307556674,0.972933164565751,-5.48885633837006,0.865091466640383,"LRRC38","leucine rich repeat containing 38",TRUE
+"227532_at",0.870821088754219,0.510510529252364,0.668833966042565,-5.7241188465332,0.393927007599349,"LRRC39","leucine rich repeat containing 39",TRUE
+"1559580_at",0.992451894371035,0.96483611767986,0.044586737216042,-5.93871525676835,0.0365346742064991,"LRRC39","leucine rich repeat containing 39",TRUE
+"229085_at",0.813631136157676,0.364294294626679,0.92625317198572,-5.53023243697596,0.686236191590876,"LRRC3B","leucine rich repeat containing 3B",TRUE
+"223552_at",0.90344422113846,0.604231520060724,-0.525827705479335,-5.80590300478542,-0.286704055394938,"LRRC4","leucine rich repeat containing 4",TRUE
+"218577_at",0.980271872113944,0.908125296651914,-0.116730430852307,-5.93304894017625,-0.0357481624036318,"LRRC40","leucine rich repeat containing 40",TRUE
+"215063_x_at",0.998347572104896,0.993135945314926,-0.00870051523595835,-5.93964661064131,-0.00325300008549245,"LRRC40","leucine rich repeat containing 40",TRUE
+"201932_at",0.659382629906731,0.127286963115869,-1.5843387062462,-4.78587775400441,-0.639831778450432,"LRRC41","leucine rich repeat containing 41",TRUE
+"1555831_s_at",0.686747966354964,0.155298616479429,-1.47119762960559,-4.9371103541493,-0.530670793848435,"LRRC41","leucine rich repeat containing 41",TRUE
+"215765_at",0.910159094731364,0.626007768473269,0.494230638204772,-5.82140674905092,0.210739721613494,"LRRC41","leucine rich repeat containing 41",TRUE
+"1558983_at",0.939452234779565,0.728889984861055,0.351018740386706,-5.87984795066626,0.179880650947774,"LRRC41","leucine rich repeat containing 41",TRUE
+"215084_s_at",0.771855357662161,0.281987354840919,1.10270896926202,-5.36417371984273,0.355550424697906,"LRRC42","leucine rich repeat containing 42",TRUE
+"1553730_x_at",0.7994347047598,0.334783970969801,0.985989038100864,-5.47695149821,0.577077525579168,"LRRC43","leucine rich repeat containing 43",TRUE
+"1553728_at",0.954685039946564,0.793674575122671,0.264716861458513,-5.90561004154463,0.143429249739919,"LRRC43","leucine rich repeat containing 43",TRUE
+"1553729_s_at",0.984161165881616,0.922755512021407,0.0980738122823047,-5.9349997629726,0.0618251278843447,"LRRC43","leucine rich repeat containing 43",TRUE
+"226253_at",0.768852835478002,0.273451495135693,-1.12301831897988,-5.3434014342669,-0.569981521801064,"LRRC45","leucine rich repeat containing 45",TRUE
+"230601_s_at",0.956398858120188,0.802161557606882,-0.253575660550948,-5.90841345912345,-0.136747372841787,"LRRC46","leucine rich repeat containing 46",TRUE
+"230600_at",0.999614041775554,0.999132622423834,-0.00109942799758634,-5.9396828920155,-0.000780527841627077,"LRRC46","leucine rich repeat containing 46",TRUE
+"212904_at",0.962377536390494,0.828629871383836,-0.219032457941443,-5.91634349841159,-0.0556425491759391,"LRRC47","leucine rich repeat containing 47",TRUE
+"219338_s_at",0.711560187204531,0.185129285102596,1.36766898764831,-5.06750863921423,0.586524270781411,"LRRC49","leucine rich repeat containing 49",TRUE
+"239320_at",0.932023157973583,0.69951741601635,0.391019638144103,-5.86548644389022,0.240724127431139,"LRRC4B","leucine rich repeat containing 4B",TRUE
+"241585_at",0.801587742916188,0.338882218025843,0.977484190261184,-5.48472295940798,0.570311893025329,"LRRC4C","leucine rich repeat containing 4C",TRUE
+"232226_at",0.806248215548257,0.347110685794063,-0.960618564247496,-5.49995251888784,-0.545394772884132,"LRRC4C","leucine rich repeat containing 4C",TRUE
+"1556484_at",0.980808506518944,0.909756427492263,-0.114648415387409,-5.93328342392677,-0.0532590306854832,"LRRC52","leucine rich repeat containing 52",TRUE
+"232856_at",0.856631989847095,0.470759512438171,0.733808907396613,-5.6807610256688,0.302327830562875,"LRRC55","leucine rich repeat containing 55",TRUE
+"232554_at",0.656793097494112,0.124921961041573,-1.59480562170787,-4.77144126547036,-0.751039164253509,"LRRC56","leucine rich repeat containing 56",TRUE
+"238495_at",0.813631136157676,0.364426710062099,0.925992629889038,-5.53045813436336,0.429548472079539,"LRRC57","leucine rich repeat containing 57",TRUE
+"229232_at",0.973567634886313,0.872800920544903,0.161965549269728,-5.92691450324135,0.0649044107117653,"LRRC57","leucine rich repeat containing 57",TRUE
+"225479_at",0.687004934564911,0.155695988005374,-1.46971722754418,-4.93902963275023,-0.426489773492474,"LRRC58","leucine rich repeat containing 58",TRUE
+"238506_at",0.761748280722165,0.260969491150946,-1.15356881415834,-5.31152431016783,-0.344590224947538,"LRRC58","leucine rich repeat containing 58",TRUE
+"234812_at",0.512962828679001,0.0344018294339038,2.25420958766588,-3.72801363302095,1.3130335961045,"LRRC59","leucine rich repeat containing 59",TRUE
+"1569371_at",0.53333138995891,0.0421756616217101,2.15629140337224,-3.89795515027841,0.776166377984451,"LRRC59","leucine rich repeat containing 59",TRUE
+"222231_s_at",0.934199247349871,0.708624515506926,-0.378550654900908,-5.87012704472257,-0.145217532762821,"LRRC59","leucine rich repeat containing 59",TRUE
+"206483_at",0.864079461576774,0.491048429636165,0.700267838913431,-5.70362134342018,0.311960568004751,"LRRC6","leucine rich repeat containing 6",TRUE
+"236587_at",0.92051722798026,0.661650211038609,-0.443576457464622,-5.84430065073402,-0.194818361198608,"LRRC6","leucine rich repeat containing 6",TRUE
+"218907_s_at",0.7846394745722,0.308463087569386,1.04240918564536,-5.42385296343168,0.551955381381763,"LRRC61","leucine rich repeat containing 61",TRUE
+"1569124_at",0.981813668015753,0.91292958515323,-0.110599597101855,-5.93372734829178,-0.116110133006942,"LRRC63","leucine rich repeat containing 63",TRUE
+"1568634_a_at",0.776955214137673,0.295521705836701,-1.07140023458109,-5.39553480883318,-0.788281076169359,"LRRC66","leucine rich repeat containing 66",TRUE
+"238214_at",0.979452359556342,0.901083446191565,0.125725012461086,-5.93198751299411,0.112146216333713,"LRRC69","leucine rich repeat containing 69",TRUE
+"1566449_at",0.585036027492332,0.0653215914298595,1.93915594032497,-4.25739890578127,0.907825852609562,"LRRC7","leucine rich repeat containing 7",TRUE
+"233499_at",0.835952408568777,0.416551447606076,0.827907870499486,-5.61123816698861,0.667440477507888,"LRRC7","leucine rich repeat containing 7",TRUE
+"1552666_a_at",0.955892698633978,0.799527424168956,-0.257030016780836,-5.90755706148499,-0.134584277216748,"LRRC7","leucine rich repeat containing 7",TRUE
+"239767_at",0.976371465776674,0.887307969180002,-0.143351960377663,-5.92967939216708,-0.163120180096276,"LRRC7","leucine rich repeat containing 7",TRUE
+"238488_at",0.992820830895496,0.966200340029602,0.0428558150861931,-5.93878897002249,0.0306306549015245,"LRRC70///IPO11","leucine rich repeat containing 70///importin 11",TRUE
+"237251_at",0.731548533938014,0.21505043845525,-1.27634497042265,-5.1759271755634,-0.876521876351624,"LRRC71","leucine rich repeat containing 71",TRUE
+"244079_at",0.981132283727686,0.910842477502513,0.11326244288637,-5.9334371802989,0.0701035019698706,"LRRC72","leucine rich repeat containing 72",TRUE
+"235935_at",0.802272124826252,0.340057731922239,-0.975057757816265,-5.48692890765872,-0.438844817286849,"LRRC73","leucine rich repeat containing 73",TRUE
+"233941_at",0.446730129062715,0.0210067336409738,2.48447774142265,-3.31131378884853,1.52772025544485,"LRRC74A","leucine rich repeat containing 74A",TRUE
+"234453_s_at",0.995623666221824,0.979151962483199,-0.026428744152251,-5.93934328334226,-0.0159353651061074,"LRRC74A","leucine rich repeat containing 74A",TRUE
+"1569213_at",0.93929971411701,0.728298724838818,-0.351817996738102,-5.87957596408151,-0.293128886233302,"LRRC74B","leucine rich repeat containing 74B",TRUE
+"229889_at",0.634202341398092,0.10534206048345,1.68849938076863,-4.63896241078256,1.6024036326264,"LRRC75A","leucine rich repeat containing 75A",TRUE
+"217668_at",0.854400503339099,0.465542179825486,0.742570449921783,-5.67462218215368,0.543787313036233,"LRRC75B","leucine rich repeat containing 75B",TRUE
+"228064_at",0.869698482173109,0.507217578076474,-0.674104334371662,-5.72074493750088,-0.721309993650745,"LRRC75B","leucine rich repeat containing 75B",TRUE
+"233487_s_at",0.6577569288805,0.126462566737848,1.58796876636866,-4.78087939451597,0.628689389356509,"LRRC8A","leucine rich repeat containing 8 family member A",TRUE
+"224624_at",0.89316156038085,0.567309758215496,0.580689490003111,-5.77676686757297,0.205667142404611,"LRRC8A","leucine rich repeat containing 8 family member A",TRUE
+"242038_at",0.754513748034606,0.247832850597753,-1.18691171949136,-5.27587731571102,-0.504075708423382,"LRRC8B","leucine rich repeat containing 8 family member B",TRUE
+"212976_at",0.912705784586886,0.633777554963433,0.483080739177005,-5.82665380004525,0.314544905912458,"LRRC8B","leucine rich repeat containing 8 family member B",TRUE
+"212978_at",0.975398143273847,0.881902205409146,-0.150281525397722,-5.92868936853719,-0.0758580459817288,"LRRC8B","leucine rich repeat containing 8 family member B",TRUE
+"218684_at",0.660460734341314,0.128452736688269,1.57923867832212,-4.79288506042359,0.656365529344772,"LRRC8D","leucine rich repeat containing 8 family member D",TRUE
+"220174_at",0.46584896273628,0.0242135362747655,2.41904752708729,-3.43200599814373,0.879477576805776,"LRRC8E","leucine rich repeat containing 8 family member E",TRUE
+"239433_at",0.73148417124022,0.214612887624658,1.27760702590507,-5.17447215488774,0.417712370513041,"LRRC8E","leucine rich repeat containing 8 family member E",TRUE
+"231872_at",0.94214388523134,0.73975742099646,-0.336369125358314,-5.88472487168438,-0.250016986143342,"LRRCC1","leucine rich repeat and coiled-coil centrosomal protein 1",TRUE
+"1569783_at",0.921312278448293,0.66480824619803,0.439146577495759,-5.84618751502167,0.462212356107327,"LRRD1","leucine rich repeats and death domain containing 1",TRUE
+"202314_at",0.587626678796111,0.0667977219068917,-1.9277781827137,-4.27552682371344,-0.668875558350651,"LRRD1///CYP51A1","leucine rich repeats and death domain containing 1///cytochrome P450 family 51 subfamily A member 1",TRUE
+"216607_s_at",0.687949239097856,0.157195739495407,-1.46415737618579,-4.94622377246765,-0.764388190248251,"LRRD1///CYP51A1","leucine rich repeats and death domain containing 1///cytochrome P450 family 51 subfamily A member 1",TRUE
+"201861_s_at",0.7768734672127,0.295033461949045,1.07251156008752,-5.39443543019944,0.40661366236214,"LRRFIP1","LRR binding FLII interacting protein 1",TRUE
+"238534_at",0.803661715437398,0.342195012993315,0.970660773347096,-5.49091360592811,0.42504777925681,"LRRFIP1","LRR binding FLII interacting protein 1",TRUE
+"215375_x_at",0.843637054204573,0.438976512868478,0.788121831876845,-5.64159641322049,0.417177612307997,"LRRFIP1","LRR binding FLII interacting protein 1",TRUE
+"223492_s_at",0.856874648266698,0.471453479642993,0.732647851304973,-5.68156933993625,0.371712081947845,"LRRFIP1","LRR binding FLII interacting protein 1",TRUE
+"238840_at",0.90808139498617,0.618619666253607,0.504892026503507,-5.81628025164008,0.460981522049833,"LRRFIP1","LRR binding FLII interacting protein 1",TRUE
+"201862_s_at",0.909891927025433,0.624916051879757,0.495802356674046,-5.82065770596483,0.175886259599125,"LRRFIP1","LRR binding FLII interacting protein 1",TRUE
+"227513_s_at",0.981916239902567,0.913258429474629,0.110180114776402,-5.93377243028059,0.0426701879253963,"LRRFIP1","LRR binding FLII interacting protein 1",TRUE
+"227391_x_at",0.988634593719643,0.945218342746909,0.0694958532147831,-5.9373313985568,0.0248676880686176,"LRRFIP1","LRR binding FLII interacting protein 1",TRUE
+"211452_x_at",0.998347572104896,0.993113788485346,-0.00872860081376142,-5.93964637222147,-0.00296639174454683,"LRRFIP1","LRR binding FLII interacting protein 1",TRUE
+"232673_at",0.472685764151413,0.0258237288984046,2.38917122424186,-3.48653138056845,1.93086619148889,"LRRFIP2","LRR binding FLII interacting protein 2",TRUE
+"220610_s_at",0.567292616148537,0.0574204612349862,2.00421975446528,-4.15234193811947,0.655385758772281,"LRRFIP2","LRR binding FLII interacting protein 2",TRUE
+"232705_at",0.616846256328144,0.0875148863344748,1.78768018349953,-4.49255522441997,1.33406690943032,"LRRFIP2","LRR binding FLII interacting protein 2",TRUE
+"232704_s_at",0.65284137151906,0.122190529369501,1.60710175199448,-4.75438738404003,0.622356454959782,"LRRFIP2","LRR binding FLII interacting protein 2",TRUE
+"218364_at",0.698445705579474,0.169708353171886,1.4193672667853,-5.0033688237944,0.461088387211483,"LRRFIP2","LRR binding FLII interacting protein 2",TRUE
+"223817_at",0.85815038001314,0.473797676822241,0.728733270538715,-5.68428566977133,0.38703155220871,"LRRIQ1","leucine rich repeats and IQ motif containing 1",TRUE
+"1553674_at",0.867099100798202,0.498985256235873,0.68736499797522,-5.71214388796126,0.285379664181233,"LRRIQ3","leucine rich repeats and IQ motif containing 3",TRUE
+"235498_at",0.9802233499944,0.907237907519618,0.117863337550162,-5.93291957781129,0.0492069696669875,"LRRIQ3","leucine rich repeats and IQ motif containing 3",TRUE
+"219441_s_at",0.199949563712201,0.00222095815620751,3.45810515097762,-1.3593969326322,2.7400857825595,"LRRK1","leucine rich repeat kinase 1",TRUE
+"1565628_at",0.410263142293979,0.0159002761503601,2.61092487723441,-3.07336288527657,2.36664468973418,"LRRK1","leucine rich repeat kinase 1",TRUE
+"229584_at",0.986455005400648,0.936830023051551,-0.0801595105675721,-5.93655431818687,-0.0935063974502297,"LRRK2","leucine rich repeat kinase 2",TRUE
+"226884_at",0.585036027492332,0.0654762716216172,-1.93795313361808,-4.25931877930306,-3.34783573631223,"LRRN1","leucine rich repeat neuronal 1",TRUE
+"205154_at",0.774230543658252,0.287702818593015,-1.08935823859212,-5.3776452297022,-1.00567596181037,"LRRN2","leucine rich repeat neuronal 2",TRUE
+"216164_at",0.818768038148976,0.372469531340834,-0.910284311881204,-5.54395752644227,-0.2851564597472,"LRRN2","leucine rich repeat neuronal 2",TRUE
+"216167_at",0.968917934155285,0.853076128965434,0.187369533146579,-5.92259844093752,0.0823296819777246,"LRRN2","leucine rich repeat neuronal 2",TRUE
+"209840_s_at",0.93527815307551,0.712214099740263,0.373652829218968,-5.87190930726295,0.409283605903972,"LRRN3","leucine rich repeat neuronal 3",TRUE
+"209841_s_at",0.973071267819624,0.869774870915629,-0.165855359928032,-5.92629422260925,-0.153668720671508,"LRRN3","leucine rich repeat neuronal 3",TRUE
+"1553169_at",0.398650588126476,0.0139764745198974,2.6687347873229,-2.96264043872093,2.06122735693689,"LRRN4","leucine rich repeat neuronal 4",TRUE
+"1553171_x_at",0.635368778245437,0.106320659976924,1.68348145017545,-4.64620350250982,1.17306871348206,"LRRN4","leucine rich repeat neuronal 4",TRUE
+"1556427_s_at",0.502810516099457,0.0324930434291966,2.28132659356553,-3.68014958318375,0.712633055006632,"LRRN4CL","LRRN4 C-terminal like",TRUE
+"238815_at",0.797856706388872,0.331773598647475,0.992282058184241,-5.47116170513979,0.568632761174381,"LRRTM1","leucine rich repeat transmembrane neuronal 1",TRUE
+"206408_at",0.909441642299191,0.623795528282235,0.497416865582031,-5.81988585187796,0.33980666994904,"LRRTM2","leucine rich repeat transmembrane neuronal 2",TRUE
+"220345_at",0.895195476627048,0.572773210029423,0.57246114838547,-5.78131541865503,0.459830336399393,"LRRTM4","leucine rich repeat transmembrane neuronal 4",TRUE
+"227675_at",0.827306067167421,0.396062849713895,-0.865456307854515,-5.58130599536633,-0.417566463558973,"LRSAM1","leucine rich repeat and sterile alpha motif containing 1",TRUE
+"235449_at",0.879960488971225,0.534999234390574,-0.630216457255926,-5.7480649598197,-0.242752671914708,"LRSAM1","leucine rich repeat and sterile alpha motif containing 1",TRUE
+"221612_at",0.823518986434235,0.390566018305711,0.875741391553299,-5.57289156800467,0.381133078194146,"LRTM1","leucine rich repeats and transmembrane domains 1",TRUE
+"91580_at",0.837609393049242,0.42196644016715,0.818180658764949,-5.6187898963761,0.475480978903929,"LRTM1","leucine rich repeats and transmembrane domains 1",TRUE
+"1558530_at",0.933649615158206,0.706418907546092,-0.381564783570687,-5.86901885991132,-0.338637436258078,"LRTM2","leucine rich repeats and transmembrane domains 2",TRUE
+"226717_at",0.740476003158683,0.229420805206327,-1.23594949522906,-5.22184784802864,-0.593227919761403,"LRTOMT","leucine rich transmembrane and O-methyltransferase domain containing",TRUE
+"1568882_at",0.884729701742031,0.54408586791934,-0.616132184229268,-5.75645753772386,-0.477426427791464,"LRTOMT","leucine rich transmembrane and O-methyltransferase domain containing",TRUE
+"229244_at",0.610033432202476,0.0822811516638053,1.82009775159584,-4.44337640082816,1.03930509108709,"LSAMP","limbic system-associated membrane protein",TRUE
+"228218_at",0.676564076407042,0.143548194068163,1.51643394126245,-4.87771462807381,1.19976442616157,"LSAMP","limbic system-associated membrane protein",TRUE
+"235494_at",0.693634792246204,0.162641024903454,1.44432479148458,-4.97170559596694,1.25992933894862,"LSAMP","limbic system-associated membrane protein",TRUE
+"235111_at",0.778397054392363,0.297986447951708,-1.06581002539884,-5.40104945257633,-0.306349613656683,"LSAMP","limbic system-associated membrane protein",TRUE
+"1570190_at",0.954054753819891,0.788896533400038,0.271004190004934,-5.9039751449055,0.149281867934391,"LSAMP","limbic system-associated membrane protein",TRUE
+"214460_at",0.983567332578112,0.919868536362568,-0.101752279647077,-5.93464191762995,-0.0745966977791372,"LSAMP","limbic system-associated membrane protein",TRUE
+"237027_at",0.744931128252932,0.236440413072259,1.21691505768468,-5.24304482648669,0.689437815381177,"LSAMP-AS1","LSAMP antisense RNA 1",TRUE
+"221535_at",0.813679506562347,0.364596876657905,0.925657901022067,-5.5307480110803,0.320582216928667,"LSG1","large 60S subunit nuclear export GTPase 1",TRUE
+"223200_s_at",0.822850703882235,0.38831186681984,0.879986266744274,-5.56939184561013,0.291330739771936,"LSG1","large 60S subunit nuclear export GTPase 1",TRUE
+"221536_s_at",0.865854896594418,0.495992975604381,0.692215671653647,-5.70895768434968,0.247433757873409,"LSG1","large 60S subunit nuclear export GTPase 1",TRUE
+"203534_at",0.632949074657601,0.104130071313026,-1.69476913949453,-4.62989203373531,-0.888152410630884,"LSM1","LSM1 homolog, mRNA degradation associated",TRUE
+"225593_at",0.54295328972902,0.0458006310216439,-2.11612357358248,-3.96630922901113,-0.649424735902567,"LSM10","LSM10, U7 small nuclear RNA associated",TRUE
+"241599_at",0.783884379328576,0.306854230805054,1.04596572338272,-5.42041651920258,0.416182583997291,"LSM11","LSM11, U7 small nuclear RNA associated",TRUE
+"242112_at",0.839519981963042,0.42730805253838,0.808661605488951,-5.62609900863723,0.350830320176583,"LSM11","LSM11, U7 small nuclear RNA associated",TRUE
+"226819_at",0.863569008901048,0.488803786437745,0.703938575568447,-5.70116913674484,0.200121144266522,"LSM11","LSM11, U7 small nuclear RNA associated",TRUE
+"226826_at",0.928295253101366,0.685153217498492,-0.41081633566184,-5.85781444839884,-0.16396071497036,"LSM11","LSM11, U7 small nuclear RNA associated",TRUE
+"212532_s_at",0.955730092376044,0.797557409496239,-0.259615547476352,-5.90690852748144,-0.0669299128421574,"LSM12","LSM12 homolog",TRUE
+"212529_at",0.993892931327222,0.971147086835171,0.0365804797212978,-5.93903174725039,0.0148354289123063,"LSM12","LSM12 homolog",TRUE
+"212132_at",0.68806049531767,0.157489576072611,-1.46307310951728,-4.94762417903296,-0.60594182881246,"LSM14A","LSM14A, mRNA processing body assembly factor",TRUE
+"222099_s_at",0.915409740314202,0.643360516040564,-0.469413729707556,-5.83292564346239,-0.143107638410239,"LSM14A","LSM14A, mRNA processing body assembly factor",TRUE
+"212131_at",0.928295253101366,0.685250873012663,-0.410681190775242,-5.85786808633785,-0.125353096822947,"LSM14A","LSM14A, mRNA processing body assembly factor",TRUE
+"219653_at",0.635368778245437,0.106502477429636,-1.68255346516815,-4.64754084065098,-0.829703201375413,"LSM14B","LSM family member 14B",TRUE
+"244488_at",0.646392036827936,0.117363553302156,1.629404536051,-4.72319638593724,0.703760939870097,"LSM14B","LSM family member 14B",TRUE
+"224171_at",0.714791050845163,0.190271037110206,1.35119114187705,-5.08753607648612,0.928903119615715,"LSM14B","LSM family member 14B",TRUE
+"231200_at",0.791683830846115,0.3223785790573,-1.01217966101848,-5.45263530309314,-0.444480707168966,"LSM14B","LSM family member 14B",TRUE
+"1553304_at",0.986889306520757,0.93901278535365,-0.0773838068487813,-5.93676724406148,-0.0312546539973511,"LSM14B","LSM family member 14B",TRUE
+"209449_at",0.778594464477313,0.298943054881289,1.06364927043974,-5.40317407738475,0.448566669647056,"LSM2","LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"236363_at",0.345235484905341,0.00876301234648433,-2.87463847394508,-2.55943713755345,-0.979166137995495,"LSM3","LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"202209_at",0.508651764521346,0.0337068585201696,-2.26391973059205,-3.71091331069166,-0.65018690106417,"LSM3","LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"202736_s_at",0.789824589976275,0.318606928528009,-1.02028117437158,-5.44499667411182,-0.351870928729753,"LSM4","LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"202737_s_at",0.885503713713074,0.547060712241431,-0.611548466382858,-5.75914946557216,-0.176369334157297,"LSM4","LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"212924_s_at",0.920488244700215,0.661455192428473,-0.443850311433432,-5.84418339537606,-0.312383131981075,"LSM4","LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"202903_at",0.386869932746877,0.0127364586912552,-2.7101166673316,-2.88268206436944,-1.0121943424333,"LSM5","LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"202904_s_at",0.776743077119289,0.294241776003215,-1.0743163732964,-5.39264784747971,-0.315081593131257,"LSM5","LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"211747_s_at",0.928244741861625,0.684541549390095,-0.411662996709457,-5.85747802020276,-0.111147521693434,"LSM5","LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"205036_at",0.703902004301726,0.175597699408056,1.39919828521137,-5.02862553805,0.354506545866546,"LSM6","LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"204559_s_at",0.84396230746828,0.440247799441729,-0.785904441588914,-5.64324701109569,-0.296176953057822,"LSM7","LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated",TRUE
+"235470_at",0.709175775230664,0.18200556887127,-1.37785697944158,-5.05502485755229,-0.658060829768516,"LSM8","LSM8 homolog, U6 small nuclear RNA associated",TRUE
+"228529_at",0.909955315434437,0.625130596420514,0.495493382146295,-5.82080513918289,0.407592926663985,"LSM8","LSM8 homolog, U6 small nuclear RNA associated",TRUE
+"219119_at",0.9330573785522,0.704389919335463,0.384340729559754,-5.86799058056769,0.103169411729192,"LSM8","LSM8 homolog, U6 small nuclear RNA associated",TRUE
+"230020_at",0.966593471043185,0.844346668891451,0.198651780172396,-5.92048099519158,0.0947026362469447,"LSM8","LSM8 homolog, U6 small nuclear RNA associated",TRUE
+"239203_at",0.497725944448536,0.0308055127081986,-2.30654278659335,-3.63533918991406,-1.60314462838816,"LSMEM1","leucine rich single-pass membrane protein 1",TRUE
+"1569852_at",0.774360462422895,0.29055837291592,-1.08275956127715,-5.38424960917427,-0.764129209893809,"LSMEM1","leucine rich single-pass membrane protein 1",TRUE
+"237024_at",0.755049574909504,0.248793345629333,1.18442980196815,-5.27856131365668,0.503189137550929,"LSMEM2","leucine rich single-pass membrane protein 2",TRUE
+"203523_at",0.908619002315341,0.619797582021809,0.503188290635221,-5.81710665683894,0.204779142621985,"LSP1","lymphocyte-specific protein 1",TRUE
+"208190_s_at",0.636147339487472,0.107547237325727,1.67724692864857,-4.65517747938959,0.946122762906752,"LSR","lipolysis stimulated lipoprotein receptor",TRUE
+"202245_at",0.587626678796111,0.0667392673549326,-1.92822451231969,-4.27481708274742,-0.693071265626422,"LSS","lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)",TRUE
+"211019_s_at",0.720654489001931,0.196748231501268,-1.33092501549899,-5.11188893953404,-0.521100610007796,"LSS","lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)",TRUE
+"211018_at",0.760227035076299,0.258039895585969,1.16089469915846,-5.30376846500497,0.435527468387629,"LSS","lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)",TRUE
+"214574_x_at",0.411110107932987,0.0162806748402609,2.60027803567487,-3.09362639779599,1.615909030222,"LST1","leukocyte specific transcript 1",TRUE
+"211581_x_at",0.848268984089208,0.447911714780483,0.772619203787177,-5.65304454429543,0.375634704460426,"LST1","leukocyte specific transcript 1",TRUE
+"210629_x_at",0.863230457544525,0.487297854143489,0.706406717786904,-5.69951344303003,0.507156326588821,"LST1","leukocyte specific transcript 1",TRUE
+"215633_x_at",0.878218253751206,0.530239014052713,-0.637646171792782,-5.7435641770638,-0.322768783110096,"LST1","leukocyte specific transcript 1",TRUE
+"214181_x_at",0.885312914741353,0.546650808192273,0.61217927118595,-5.75878015652897,0.337974953915227,"LST1","leukocyte specific transcript 1",TRUE
+"211582_x_at",0.989524702314661,0.948416321880533,0.0654326618542452,-5.93759836761086,0.0223738627820316,"LST1","leukocyte specific transcript 1",TRUE
+"206975_at",0.973493137611142,0.872267087386453,0.162651573159519,-5.92680617423129,0.0546430123413231,"LTA","lymphotoxin alpha",TRUE
+"207339_s_at",0.514490373584066,0.0347181779610693,2.24984873597986,-3.735679179494,1.29884030133113,"LTB","lymphotoxin beta",TRUE
+"1559754_at",0.789795896476304,0.317886598687671,1.02183606103707,-5.44352432923035,0.37299938805286,"LTB","lymphotoxin beta",TRUE
+"216388_s_at",0.687545925823023,0.156348975157894,-1.46729117387954,-4.94217152716094,-0.812044396883201,"LTB4R","leukotriene B4 receptor",TRUE
+"236172_at",0.8920930097751,0.563590949064092,0.586313484454636,-5.77362182938425,0.231822076318418,"LTB4R","leukotriene B4 receptor",TRUE
+"210128_s_at",0.976589025744684,0.888507014971128,0.141815907752598,-5.92989253294524,0.0657701775381296,"LTB4R","leukotriene B4 receptor",TRUE
+"220130_x_at",0.817889575750373,0.370817818272264,0.913491719230368,-5.54121844881635,0.407952911769064,"LTB4R2","leukotriene B4 receptor 2",TRUE
+"202729_s_at",0.63418824799514,0.105008300577086,-1.69021982829966,-4.63647598560358,-0.981429447568141,"LTBP1","latent transforming growth factor beta binding protein 1",TRUE
+"202728_s_at",0.820536502908875,0.38010565293706,-0.895576919705245,-5.55640343431833,-0.740703534416456,"LTBP1","latent transforming growth factor beta binding protein 1",TRUE
+"204682_at",0.00380048018143725,7.64614211171645e-07,6.79425782897433,5.56525156155775,2.91940641510705,"LTBP2","latent transforming growth factor beta binding protein 2",TRUE
+"223690_at",0.384586587899771,0.0125363434929743,2.71714924328155,-2.86903732046413,1.44142940128649,"LTBP2","latent transforming growth factor beta binding protein 2",TRUE
+"219922_s_at",0.896118635245982,0.578285185741749,-0.564199980071243,-5.78581883477183,-0.333319418567235,"LTBP3","latent transforming growth factor beta binding protein 3",TRUE
+"227308_x_at",0.915939421175188,0.645073715131307,-0.46698000882702,-5.8340240095227,-0.176273295587086,"LTBP3","latent transforming growth factor beta binding protein 3",TRUE
+"237144_at",0.97345342693821,0.871806393646829,0.163243670511557,-5.92671230983165,0.0876913778378876,"LTBP3","latent transforming growth factor beta binding protein 3",TRUE
+"210628_x_at",0.710672261019989,0.183801527196502,1.37198271037776,-5.06223225785288,0.565328664639093,"LTBP4","latent transforming growth factor beta binding protein 4",TRUE
+"227989_at",0.821137675198948,0.382172335142748,0.891629921766952,-5.55971160861486,0.674885578937176,"LTBP4","latent transforming growth factor beta binding protein 4",TRUE
+"204442_x_at",0.852409445602775,0.458272360751471,0.754876659323918,-5.66588315496159,0.577853400000739,"LTBP4","latent transforming growth factor beta binding protein 4",TRUE
+"213176_s_at",0.957571530817866,0.809540814838734,-0.243915252811117,-5.91074730346855,-0.234419133970515,"LTBP4","latent transforming growth factor beta binding protein 4",TRUE
+"232819_s_at",0.647455721425462,0.118225524242136,1.62536620275605,-4.72886869440255,0.858637389857069,"LTBR","lymphotoxin beta receptor",TRUE
+"1559458_at",0.715352956634026,0.191093014117009,1.34858956746587,-5.09067952288693,0.898462268988086,"LTBR","lymphotoxin beta receptor",TRUE
+"243400_x_at",0.769847953580141,0.2779127932914,1.11234691571886,-5.3543579879279,0.351547717312243,"LTBR","lymphotoxin beta receptor",TRUE
+"203005_at",0.937517914799988,0.723076502459371,0.358887538734553,-5.87714359342917,0.178501934048327,"LTBR","lymphotoxin beta receptor",TRUE
+"206480_at",0.950870395622221,0.77545431622621,0.288753471708247,-5.89915425212637,0.165700378343539,"LTC4S","leukotriene C4 synthase",TRUE
+"202018_s_at",0.580630437263151,0.0631841424323824,1.95603930630868,-4.2303642285082,0.801715253220381,"LTF","lactotransferrin",TRUE
+"217184_s_at",0.869438938525166,0.506493471356951,0.675265838648336,-5.71999797382935,0.415320181622164,"LTK","leukocyte receptor tyrosine kinase",TRUE
+"207106_s_at",0.886783047600321,0.550242009224551,0.606661207071881,-5.76199829779504,0.287720423518413,"LTK","leukocyte receptor tyrosine kinase",TRUE
+"233818_at",0.694819513561858,0.164292156546079,1.43841705520313,-4.9792414035002,1.09448782723833,"LTN1","listerin E3 ubiquitin protein ligase 1",TRUE
+"215596_s_at",0.75710709622615,0.252908445699412,1.17387666840038,-5.28991891283031,0.325507367316517,"LTN1","listerin E3 ubiquitin protein ligase 1",TRUE
+"233819_s_at",0.925993992481316,0.679180815482135,0.419096431659093,-5.85449503405617,0.187004796158517,"LTN1","listerin E3 ubiquitin protein ligase 1",TRUE
+"225748_at",0.813442508625161,0.363728953620251,-0.92736625569403,-5.52926755832392,-0.333483925351686,"LTV1","LTV1 ribosome biogenesis factor",TRUE
+"239212_at",0.959120911159536,0.814589367550323,0.2373197398782,-5.91228893420634,0.0995965357961373,"LTV1","LTV1 ribosome biogenesis factor",TRUE
+"223295_s_at",0.474859593446097,0.0260422072411891,-2.38525093358768,-3.49365820153632,-0.985788200922981,"LUC7L","LUC7 like",TRUE
+"1557067_s_at",0.522403182336918,0.0381758500735906,-2.20440899530454,-3.81502081906494,-0.848908233316118,"LUC7L","LUC7 like",TRUE
+"220143_x_at",0.634202341398092,0.105356884622568,-1.68842307336027,-4.63907264752405,-0.525411403019548,"LUC7L","LUC7 like",TRUE
+"223546_x_at",0.643075683233406,0.113254243326099,-1.64900601015773,-4.69551031096244,-0.595921599907736,"LUC7L","LUC7 like",TRUE
+"1557066_at",0.806697551763868,0.347884133186505,-0.959047327764577,-5.50135900264521,-0.494818849675865,"LUC7L","LUC7 like",TRUE
+"243852_at",0.592488489935347,0.0695865379779941,-1.9068729757921,-4.30864216502675,-0.588624890158417,"LUC7L2","LUC7 like 2, pre-mRNA splicing factor",TRUE
+"226758_at",0.633326968581968,0.104556272170623,-1.6925573294176,-4.63309472285475,-0.544981781177874,"LUC7L2","LUC7 like 2, pre-mRNA splicing factor",TRUE
+"203804_s_at",0.693286330555422,0.162452755683784,-1.44500148263764,-4.97084081252324,-0.538554418442205,"LUC7L3","LUC7 like 3 pre-mRNA splicing factor",TRUE
+"220044_x_at",0.693851377449481,0.163154864306143,-1.44248111975788,-4.97406005678247,-0.507385302973411,"LUC7L3","LUC7 like 3 pre-mRNA splicing factor",TRUE
+"242389_at",0.751579819725748,0.244882534205292,-1.19458062955942,-5.26755306635519,-0.738840334255944,"LUC7L3","LUC7 like 3 pre-mRNA splicing factor",TRUE
+"208835_s_at",0.787813843760597,0.313699043301545,-1.03092448927689,-5.4348778668941,-0.466210483638049,"LUC7L3","LUC7 like 3 pre-mRNA splicing factor",TRUE
+"241792_x_at",0.859276375962637,0.476263638559353,-0.724627618176426,-5.68711972969691,-0.380692329469115,"LUC7L3","LUC7 like 3 pre-mRNA splicing factor",TRUE
+"229193_at",0.990797621966014,0.953340833391902,0.0591780073146526,-5.93797791180651,0.0324813482290223,"LUC7L3","LUC7 like 3 pre-mRNA splicing factor",TRUE
+"201744_s_at",0.0512940355329115,7.13003511751491e-05,4.86766493655377,1.66866613453419,6.55675705888144,"LUM","lumican",TRUE
+"229554_at",0.40221114169538,0.0145356173897027,2.65119701731276,-2.99635276812644,1.21291094693825,"LUM","lumican",TRUE
+"215679_at",0.876676432191289,0.525669138600077,0.644812940806517,-5.73917463544722,0.61167383032377,"LUNAR1","leukemia-associated non-coding IGF1R activator RNA 1",TRUE
+"235214_at",0.878260796317638,0.530699226131543,0.636926303429937,-5.74400247946466,0.292154824846264,"LURAP1","leucine rich adaptor protein 1",TRUE
+"227443_at",0.778146335240385,0.297524446972112,-1.06685535298129,-5.40002021815467,-1.18626998375841,"LURAP1L","leucine rich adaptor protein 1 like",TRUE
+"242893_at",0.675352428480841,0.141590054441858,1.52426434821447,-4.86728714829466,1.25941544645862,"LURAP1L-AS1","LURAP1L antisense RNA 1",TRUE
+"221831_at",0.121384106087039,0.000679351375631162,3.94671373681546,-0.315560845163668,1.33445124420815,"LUZP1","leucine zipper protein 1",TRUE
+"1558173_a_at",0.189644672791897,0.00192159394104639,3.51833719483844,-1.23203640619375,1.44104094084558,"LUZP1","leucine zipper protein 1",TRUE
+"225831_at",0.242153081287708,0.00324199461367356,3.29979414541938,-1.69161128422107,1.06265638886927,"LUZP1","leucine zipper protein 1",TRUE
+"221832_s_at",0.358427723880268,0.00987051562535245,2.82260710417789,-2.66254901434714,1.08335314186616,"LUZP1","leucine zipper protein 1",TRUE
+"1553224_at",0.541849190341655,0.0452483961977382,2.1220535351846,-3.95626930888688,1.67431812464551,"LUZP1","leucine zipper protein 1",TRUE
+"215323_at",0.610455440146151,0.083057450771675,1.81517872511671,-4.45087987853476,1.04163478108586,"LUZP2","leucine zipper protein 2",TRUE
+"220665_at",0.88767000285873,0.552218218434247,0.603632752223641,-5.76375254397457,0.446000385948906,"LUZP4","leucine zipper protein 4",TRUE
+"224656_s_at",0.867972140419125,0.501481073043717,0.683331748607466,-5.71477685976554,0.171970011498006,"LUZP6///MTPN","leucine zipper protein 6///myotrophin",TRUE
+"1557219_at",0.840268837320073,0.429373774223734,0.805000272436911,-5.62888894980426,0.490201617926759,"LVCAT1","liver cancer-associated transcript 1",TRUE
+"235382_at",0.379036201319067,0.0116466541969096,2.7497594494487,-2.80555738560364,3.42624599060119,"LVRN","laeverin",TRUE
+"218729_at",0.812302873476553,0.358163255928924,0.938386758103488,-5.5196569374542,1.87645758161887,"LXN","latexin",TRUE
+"206276_at",0.636147339487472,0.107345621849423,1.67826756420039,-4.65371010089738,1.72981229079477,"LY6D","lymphocyte antigen 6 complex, locus D",TRUE
+"202145_at",0.891444650197327,0.561057417741808,-0.590155919570079,-5.77145621107794,-0.577568649811056,"LY6E","lymphocyte antigen 6 complex, locus E",TRUE
+"231777_at",0.967098323798013,0.846235429226004,0.196208496925205,-5.92095001073627,0.0994722508239718,"LY6G5B///CSNK2B","lymphocyte antigen 6 complex, locus G5B///casein kinase 2 beta",TRUE
+"219860_at",0.944052844220435,0.750012839838435,-0.322613089139382,-5.88911709046107,-0.162740295031957,"LY6G5C","lymphocyte antigen 6 complex, locus G5C",TRUE
+"207114_at",0.663252754612157,0.131206982970006,1.56734032368862,-4.8091642635952,0.945225741627316,"LY6G6C","lymphocyte antigen 6 complex, locus G6C",TRUE
+"221338_at",0.256999052540656,0.00376577904842486,-3.23667409757469,-1.82289771159803,-1.98461191902514,"LY6G6E","lymphocyte antigen 6 complex, locus G6E",TRUE
+"234897_s_at",0.930608206400412,0.69291376465589,0.400100543129069,-5.86201354632164,0.264734584630216,"LY6G6F///LY6G6D","lymphocyte antigen 6 complex, locus G6F///lymphocyte antigen 6 complex, locus G6D",TRUE
+"207457_s_at",0.982909728377256,0.917173364571978,0.105187655876996,-5.93429583503733,0.047359362974631,"LY6G6F///LY6G6D","lymphocyte antigen 6 complex, locus G6F///lymphocyte antigen 6 complex, locus G6D",TRUE
+"206773_at",0.519956259865057,0.0375992095166936,-2.21171980148091,-3.80232178184167,-1.20774938005127,"LY6H","lymphocyte antigen 6 complex, locus H",TRUE
+"223687_s_at",0.405851918322614,0.0151948582863538,2.63131775365329,-3.03443780177089,4.04160782745308,"LY6K","lymphocyte antigen 6 complex, locus K",TRUE
+"223688_s_at",0.554642754132296,0.0510218591257961,2.06302673501426,-4.0554012172017,1.6978754851061,"LY6K","lymphocyte antigen 6 complex, locus K",TRUE
+"205668_at",0.00967620466954384,4.9553494421075e-06,5.9803343618877,3.9816238657164,4.93079443907491,"LY75","lymphocyte antigen 75",TRUE
+"203799_at",0.849935057946582,0.452418102824668,0.764871923564198,-5.65868518968652,1.38729248518602,"LY75-CD302///CD302///LY75","LY75-CD302 readthrough///CD302 molecule///lymphocyte antigen 75",TRUE
+"205859_at",0.936599157163462,0.716931003470362,0.367230929391762,-5.87421146169778,0.11948491423704,"LY86","lymphocyte antigen 86",TRUE
+"1556366_s_at",0.820611742812032,0.381121438768967,0.893635193225336,-5.55803258143528,0.486769903712976,"LY86-AS1","LY86 antisense RNA 1",TRUE
+"1553428_at",0.837337084923913,0.42003100341783,0.821648319581697,-5.61610736335582,0.531489162407031,"LY86-AS1","LY86 antisense RNA 1",TRUE
+"1556365_at",0.919406408954167,0.65761971924329,-0.449243303142653,-5.84185982752516,-0.260079725401665,"LY86-AS1","LY86 antisense RNA 1",TRUE
+"231124_x_at",0.499983604958508,0.0317227823612449,-2.29268377434613,-3.66000296410995,-1.57550338645466,"LY9","lymphocyte antigen 9",TRUE
+"210370_s_at",0.952613441433926,0.782826963268297,-0.279007174062442,-5.90183901343129,-0.199241345695041,"LY9","lymphocyte antigen 9",TRUE
+"215967_s_at",0.978928101156583,0.897442765942754,0.130379387965125,-5.93140738946379,0.0695825747509669,"LY9","lymphocyte antigen 9",TRUE
+"206584_at",0.767945391174396,0.270560334835392,1.1300020432412,-5.33618100965218,0.918359061236352,"LY96","lymphocyte antigen 96",TRUE
+"223413_s_at",0.987509694080412,0.941218201699468,0.0745799276345483,-5.93697471804202,0.0456716222746234,"LYAR","Ly1 antibody reactive",TRUE
+"223414_s_at",0.992031007642741,0.963121457576522,-0.0467624926254568,-5.93861846096554,-0.0204814510413804,"LYAR","Ly1 antibody reactive",TRUE
+"236706_at",0.657571067962164,0.126336637758528,-1.58852500067526,-4.78011270680114,-0.869921729382976,"LYG1","lysozyme g1",TRUE
+"1554398_at",0.952339611416198,0.781874206028807,-0.280265102802424,-5.9014976394358,-0.201151330980557,"LYG2","lysozyme g2",TRUE
+"210044_s_at",0.873230718105642,0.51766360841262,0.657450428520038,-5.73131960182196,0.305447321553595,"LYL1","LYL1, basic helix-loop-helix family member",TRUE
+"210754_s_at",0.456898036702485,0.0224691143439348,2.45356621530453,-3.36854847486021,2.34580069414343,"LYN","LYN proto-oncogene, Src family tyrosine kinase",TRUE
+"202626_s_at",0.464325074629755,0.0238545954978172,2.42595754342856,-3.41934203978275,2.97462125936716,"LYN","LYN proto-oncogene, Src family tyrosine kinase",TRUE
+"202625_at",0.552420073963858,0.0497725427382079,2.0752720711078,-4.03498437738265,2.90756128281669,"LYN","LYN proto-oncogene, Src family tyrosine kinase",TRUE
+"1559388_a_at",0.497725944448536,0.0308204084585106,2.30631472230231,-3.63574575753162,0.673603378497976,"LYNX1","Ly6/neurotoxin 1",TRUE
+"1554179_s_at",0.58734491878445,0.0663347942111382,1.93132232430119,-4.26988790529334,0.529525111086137,"LYNX1","Ly6/neurotoxin 1",TRUE
+"226305_at",0.689950875648652,0.159301751370693,1.45642207447496,-4.95619603796321,1.45213410345144,"LYNX1","Ly6/neurotoxin 1",TRUE
+"244224_x_at",0.975398143273847,0.881451568208768,0.150859525835404,-5.92860468304065,0.124543568214888,"LYNX1","Ly6/neurotoxin 1",TRUE
+"212909_at",0.869441836317963,0.506602901405136,0.675090247431646,-5.72011097553452,0.805404402340437,"LYPD1","LY6/PLAUR domain containing 1",TRUE
+"204952_at",0.91981276720654,0.65888371335426,0.447464535562756,-5.84262925087132,0.477485753258435,"LYPD3","LY6/PLAUR domain containing 3",TRUE
+"231266_at",0.70939075283402,0.182416609102381,1.37650849929147,-5.05668163050081,0.584112325195634,"LYPD4","LY6/PLAUR domain containing 4",TRUE
+"1569772_x_at",0.958723944343516,0.812868146098443,-0.239567148265938,-5.91176834649403,-0.208526605938261,"LYPD4","LY6/PLAUR domain containing 4",TRUE
+"236039_at",0.384586587899771,0.012576878265474,2.71571621553589,-2.87181901945568,1.9708182781716,"LYPD5","LY6/PLAUR domain containing 5",TRUE
+"239028_at",0.77364996239449,0.28502306896581,-1.09559375075658,-5.37137148033861,-0.551401081252159,"LYPD6","LY6/PLAUR domain containing 6",TRUE
+"227764_at",0.826088985184893,0.393669778981756,-0.869922534494375,-5.57766343545298,-1.16671449253418,"LYPD6","LY6/PLAUR domain containing 6",TRUE
+"227763_at",0.991215113882097,0.958706112096848,-0.0523662753573314,-5.9383479314419,-0.0338801507419593,"LYPD6","LY6/PLAUR domain containing 6",TRUE
+"228360_at",0.969882914559333,0.856485268252649,0.182970277994523,-5.9233906640228,0.138270298202485,"LYPD6B","LY6/PLAUR domain containing 6B",TRUE
+"1568933_at",0.718706241731185,0.194699538422854,1.33727771747599,-5.10428842845378,1.13255443341853,"LYPD8","LY6/PLAUR domain containing 8",TRUE
+"238143_at",0.752913428584105,0.246131172194451,1.1913265793244,-5.27109089152262,0.514527698577719,"LYPD8","LY6/PLAUR domain containing 8",TRUE
+"212449_s_at",0.941106542715586,0.735796652524611,0.341699495125405,-5.88297415504596,0.137143827120296,"LYPLA1","lysophospholipase I",TRUE
+"203007_x_at",0.97771449920834,0.892344421124744,0.136902279057054,-5.9305589504701,0.0564279686341909,"LYPLA1","lysophospholipase I",TRUE
+"216606_x_at",0.743482925985952,0.233887979743818,1.22378608266608,-5.23542595169493,0.27524043362058,"LYPLA2","lysophospholipase II",TRUE
+"215568_x_at",0.861659105448003,0.482623112910665,0.714096573446182,-5.6943195000117,0.18158659187349,"LYPLA2","lysophospholipase II",TRUE
+"215566_x_at",0.87045636854107,0.509070231881697,0.671136812114617,-5.722647762185,0.170821721450775,"LYPLA2","lysophospholipase II",TRUE
+"202292_x_at",0.942856731597582,0.74397302450083,0.330706693393241,-5.8865548252252,0.0770165889437688,"LYPLA2","lysophospholipase II",TRUE
+"230174_at",0.931582451098271,0.698068697611272,-0.393008929485306,-5.86473237827623,-0.43492304990815,"LYPLAL1","lysophospholipase like 1",TRUE
+"226851_at",0.955904644595647,0.80076544141604,0.255406107299461,-5.90796109233809,0.340815341731952,"LYPLAL1","lysophospholipase like 1",TRUE
+"203897_at",0.73223722457785,0.216110932131248,-1.27329430490828,-5.17943921230645,-0.536683995048536,"LYRM1","LYR motif containing 1",TRUE
+"226919_at",0.777463110382572,0.296329379026552,1.06956471512799,-5.39734836350533,0.388592253610963,"LYRM2","LYR motif containing 2",TRUE
+"227712_at",0.829626140494984,0.401086447272163,0.856136979751841,-5.58885045651741,0.286038256988297,"LYRM2","LYR motif containing 2",TRUE
+"221311_x_at",0.909052380289506,0.622561040389156,0.499197133264411,-5.81903191267472,0.17746441403337,"LYRM2","LYR motif containing 2",TRUE
+"227797_x_at",0.920119557710459,0.659731363351653,0.446272493414897,-5.8431432047656,0.135139280403584,"LYRM2","LYR motif containing 2",TRUE
+"233763_at",0.962755472789636,0.830566989310316,0.216515556011547,-5.91687621449903,0.120077762215675,"LYRM2","LYR motif containing 2",TRUE
+"218561_s_at",0.487553723496951,0.0288109580425186,2.33803467428387,-3.57897642902197,1.08543398103029,"LYRM4","LYR motif containing 4",TRUE
+"222672_at",0.547343369043481,0.0477460167690943,2.0957338326206,-4.0006937911628,0.888998000434184,"LYRM4","LYR motif containing 4",TRUE
+"1556555_at",0.707310728640006,0.178823158701249,1.38837995402579,-5.04204987214351,0.543807630752217,"LYRM4-AS1","LYRM4 antisense RNA 1",TRUE
+"225469_at",0.901910595357431,0.60004598403396,-0.531962453906464,-5.80278439996346,-0.226208463175844,"LYRM5","LYR motif containing 5",TRUE
+"231640_at",0.930899509890345,0.694217646298142,-0.398304840969194,-5.86270652257508,-0.338541802635974,"LYRM5","LYR motif containing 5",TRUE
+"239960_x_at",0.823074246722209,0.389309042077785,0.878106478529234,-5.57094358999257,0.545780510342934,"LYRM7","LYR motif containing 7",TRUE
+"231840_x_at",0.840879524142924,0.430450244468135,-0.803096648706963,-5.63033481552744,-0.413420481342715,"LYRM7","LYR motif containing 7",TRUE
+"228841_at",0.913782990161554,0.638553391954321,-0.476258041252195,-5.82980677333247,-0.236696307186291,"LYRM7","LYR motif containing 7",TRUE
+"240344_x_at",0.97443071982529,0.874811345500431,-0.15938268247158,-5.92731826300829,-0.0783505476648028,"LYRM7","LYR motif containing 7",TRUE
+"213195_at",0.623667408398064,0.0949917550139289,-1.74415257963531,-4.55757136936644,-0.656967370428764,"LYRM9","LYR motif containing 9",TRUE
+"1560703_at",0.687659256779784,0.156712822893854,-1.46594292574011,-4.94391577761515,-0.722277447608231,"LYRM9","LYR motif containing 9",TRUE
+"232283_at",0.883952384679702,0.5424589423394,0.618644625446722,-5.75497380874707,0.233688724388463,"LYSMD1","LysM domain containing 1",TRUE
+"226748_at",0.89961817630669,0.590658278955531,-0.545797990098573,-5.79562195982701,-0.393157406047582,"LYSMD2","LysM domain containing 2",TRUE
+"226321_at",0.812302873476553,0.358213022766871,-0.938287708537463,-5.5197437798425,-0.325410697434041,"LYSMD3","LysM domain containing 3",TRUE
+"228954_at",0.919156359329732,0.655753454640103,0.451872317589087,-5.84071713985176,0.220565398244648,"LYSMD4","LysM domain containing 4",TRUE
+"215415_s_at",0.858826390511142,0.475057057220259,-0.726634928781599,-5.68573601926577,-0.405654476061097,"LYST","lysosomal trafficking regulator",TRUE
+"1562511_at",0.932830928398943,0.703683785156196,0.385307542689815,-5.86763072362283,0.317848853701268,"LYST","lysosomal trafficking regulator",TRUE
+"210943_s_at",0.936318756756998,0.715717182286494,0.368881990939102,-5.873623342416,0.116642512410122,"LYST","lysosomal trafficking regulator",TRUE
+"203518_at",0.953983577550391,0.788688096302214,-0.271278720492159,-5.90390289035004,-0.161284181150844,"LYST","lysosomal trafficking regulator",TRUE
+"220037_s_at",0.932091525948902,0.700477732421727,0.389701875642934,-5.86598388201346,0.321909367799815,"LYVE1","lymphatic vessel endothelial hyaluronan receptor 1",TRUE
+"219059_s_at",0.978276691813018,0.895454986198792,0.132921875226826,-5.93108160206504,0.0879210986276071,"LYVE1","lymphatic vessel endothelial hyaluronan receptor 1",TRUE
+"213975_s_at",0.579119470758542,0.0622925658153176,-1.96323110750497,-4.21879968941279,-2.21305508813771,"LYZ","lysozyme",TRUE
+"1555745_a_at",0.957430653957785,0.807453561263817,-0.246645293205021,-5.91009689055497,-0.171127076774575,"LYZ","lysozyme",TRUE
+"233973_at",0.789614764278615,0.3169655235396,1.02382787120482,-5.4416352955151,0.751622891492948,"LYZL1","lysozyme like 1",TRUE
+"230514_s_at",0.610033432202476,0.0826082814100345,-1.81802001201079,-4.44654756702527,-1.50090933455501,"LYZL2///LYZL1","lysozyme like 2///lysozyme like 1",TRUE
+"231306_at",0.796327569283512,0.328614807641962,-0.998927897141645,-5.46501097108366,-0.50344118333114,"LYZL4","lysozyme like 4",TRUE
+"207343_at",0.847797601020174,0.447154023706635,0.77392644409169,-5.65208747621098,0.236019565995978,"LYZL6","lysozyme like 6",TRUE
+"226087_at",0.896159990898752,0.579191460056706,0.562845490517172,-5.78655115227846,0.189467439178021,"LZIC","leucine zipper and CTNNBIP1 domain containing",TRUE
+"226081_at",0.930899509890345,0.694401913282185,-0.398051176579607,-5.862804166306,-0.10587079004665,"LZIC","leucine zipper and CTNNBIP1 domain containing",TRUE
+"226532_at",0.980459547037842,0.908893830782845,0.115749389742902,-5.93315995346392,0.0357330335041439,"LZIC","leucine zipper and CTNNBIP1 domain containing",TRUE
+"237553_at",0.789850877773366,0.31873870594498,1.01999698915327,-5.44526555420369,0.285958972457895,"LZTFL1","leucine zipper transcription factor like 1",TRUE
+"218437_s_at",0.862634144901168,0.485706550275416,0.709019568080748,-5.69775465878453,0.343165472431672,"LZTFL1","leucine zipper transcription factor like 1",TRUE
+"222632_s_at",0.890508482723444,0.559224668574476,0.592941122014773,-5.76987790489362,0.280026623628187,"LZTFL1","leucine zipper transcription factor like 1",TRUE
+"232418_at",0.965584868976477,0.83905099168615,0.205508873692498,-5.91913381700825,0.129756133749058,"LZTFL1","leucine zipper transcription factor like 1",TRUE
+"203412_at",0.853297110808539,0.459959272624808,-0.75201075755556,-5.66793047226976,-0.251021864988237,"LZTR1","leucine zipper like transcription regulator 1",TRUE
+"222107_x_at",0.74126098489332,0.231929959843268,-1.2290955664581,-5.2295131906523,-0.748637269612026,"LZTS1","leucine zipper tumor suppressor 1",TRUE
+"221721_s_at",0.774230543658252,0.287152827881507,1.09063458318229,-5.37636365431871,0.328614045744317,"LZTS1","leucine zipper tumor suppressor 1",TRUE
+"221722_x_at",0.791045390251277,0.321135480979777,1.01484248966752,-5.45013069499887,0.286302349886834,"LZTS1","leucine zipper tumor suppressor 1",TRUE
+"1569159_at",0.805654356268614,0.345013097351136,0.964891782265237,-5.49611672576708,0.43149738258654,"LZTS1","leucine zipper tumor suppressor 1",TRUE
+"47550_at",0.871165715950006,0.511690461362181,-0.666950114269567,-5.72531867143421,-0.630848860348654,"LZTS1","leucine zipper tumor suppressor 1",TRUE
+"221719_s_at",0.93423034725099,0.708822028540222,-0.378280913086515,-5.87022579636376,-0.222250894396871,"LZTS1","leucine zipper tumor suppressor 1",TRUE
+"219042_at",0.961561244483099,0.825939978658453,-0.222529847017791,-5.91559308283326,-0.189467968521249,"LZTS1","leucine zipper tumor suppressor 1",TRUE
+"1559880_at",0.85334340854827,0.460947671085214,0.75033448459984,-5.66912453574805,0.55759571074428,"LZTS1-AS1","LZTS1 antisense RNA 1",TRUE
+"225013_at",0.477266692481162,0.026510451670147,2.37695019587076,-3.5087268280803,1.21209990714543,"LZTS2","leucine zipper tumor suppressor 2",TRUE
+"232129_s_at",0.68041487556515,0.147953962307449,-1.49913058534474,-4.90060463617872,-0.686260730893749,"LZTS2","leucine zipper tumor suppressor 2",TRUE
+"224473_x_at",0.763502833200335,0.263329668316961,-1.14771093622795,-5.31769494692102,-0.409340509478097,"LZTS2","leucine zipper tumor suppressor 2",TRUE
+"1555881_s_at",0.784789297644843,0.309259330572632,-1.04065386144967,-5.42554513371092,-0.316879379706613,"LZTS2","leucine zipper tumor suppressor 2",TRUE
+"204447_at",0.987532129750619,0.94132989494674,-0.0744379417441912,-5.93698502077868,-0.0473685567974194,"LZTS3","leucine zipper tumor suppressor family member 3",TRUE
+"234325_at",0.232037111848437,0.00297454580027292,3.33596160557592,-1.61606742856114,1.45487297950526,"M1AP","meiosis 1 associated protein",TRUE
+"1552849_at",0.606900628956089,0.0803392956618858,-1.83258078678324,-4.42426929768614,-2.22236677811254,"M1AP","meiosis 1 associated protein",TRUE
+"234498_at",0.694526899259872,0.164095079737339,-1.4391196744851,-4.97834647508251,-0.761242031523625,"M1AP","meiosis 1 associated protein",TRUE
+"1555148_a_at",0.716156128190082,0.191852561675357,-1.3461933956811,-5.09357029650152,-1.51012470733374,"M1AP","meiosis 1 associated protein",TRUE
+"200900_s_at",0.674680903837191,0.14106908262765,1.52636262373618,-4.86448568280642,0.67501888164367,"M6PR","mannose-6-phosphate receptor, cation dependent",TRUE
+"200901_s_at",0.691626147814603,0.161277437911656,1.4492402543181,-4.96541632978912,0.477757292048931,"M6PR///PHC1","mannose-6-phosphate receptor, cation dependent///polyhomeotic homolog 1",TRUE
+"236222_at",0.719333457476224,0.195260417775822,1.33553332554011,-5.10637848580728,0.750677176477023,"MAATS1","MYCBP associated and testis expressed 1",TRUE
+"1556487_a_at",0.774230543658252,0.287427538024329,1.08999685260146,-5.37700416561512,0.844148311059732,"MAATS1","MYCBP associated and testis expressed 1",TRUE
+"1555719_a_at",0.80110325033185,0.337781626359235,-0.979761210499599,-5.48264830183447,-0.841413010185059,"MAATS1","MYCBP associated and testis expressed 1",TRUE
+"1556488_s_at",0.909445650446618,0.624111755837358,-0.496961092840932,-5.82010399301247,-0.356127556721144,"MAATS1","MYCBP associated and testis expressed 1",TRUE
+"1554528_at",0.913895480987494,0.638692417708452,0.476059775579493,-5.82989774190626,0.328721009204783,"MAATS1","MYCBP associated and testis expressed 1",TRUE
+"1554147_s_at",0.915939421175188,0.645133649043747,0.466894920338155,-5.83406230979125,0.40461625428639,"MAATS1","MYCBP associated and testis expressed 1",TRUE
+"1561429_a_at",0.945723453271709,0.754981388202239,-0.315971492937931,-5.89117272780526,-0.197976976834151,"MAATS1","MYCBP associated and testis expressed 1",TRUE
+"1561430_s_at",0.959357995170594,0.8161319835028,0.235306599295166,-5.91275111264785,0.0697780347023373,"MAATS1","MYCBP associated and testis expressed 1",TRUE
+"210303_at",0.622917527985155,0.0938602649439475,1.75054648641872,-4.54809487109356,1.15935477651856,"MAB21L2","mab-21 like 2",TRUE
+"210302_s_at",0.914746370982129,0.640775406370065,-0.47309152110918,-5.83125521018329,-0.189267826990552,"MAB21L2","mab-21 like 2",TRUE
+"1553333_at",0.70939075283402,0.182349582528729,1.376728225752,-5.05641176155546,1.55278452896786,"MAB21L3","mab-21 like 3",TRUE
+"232151_at",0.194346670732407,0.00207942939878296,3.48552040805875,-1.30148726242931,2.86537082232742,"MACC1","metastasis associated in colon cancer 1",TRUE
+"1566764_at",0.470726957161354,0.0253313354093702,2.39812009630063,-3.47023860385572,2.66513289128203,"MACC1","metastasis associated in colon cancer 1",TRUE
+"1566766_a_at",0.51470556386048,0.0351095774054038,2.24450320245446,-3.74506350262102,2.02616572667001,"MACC1","metastasis associated in colon cancer 1",TRUE
+"1553407_at",0.635368778245437,0.106405557662372,-1.68304797049782,-4.6468282683121,-1.03787621307287,"MACF1","microtubule-actin crosslinking factor 1",TRUE
+"208633_s_at",0.713633547141264,0.188410744473723,1.35711184187435,-5.08036329493261,0.975494030982555,"MACF1","microtubule-actin crosslinking factor 1",TRUE
+"232168_x_at",0.796526145641047,0.329344786943497,0.997388165122254,-5.46643931396339,0.503365852517128,"MACF1","microtubule-actin crosslinking factor 1",TRUE
+"207358_x_at",0.801547748171611,0.338349936160453,0.978584796477191,-5.48372071520121,0.754202997371593,"MACF1","microtubule-actin crosslinking factor 1",TRUE
+"241896_at",0.819780516863333,0.377307631966514,0.900943178905885,-5.55188402777071,0.508923574971004,"MACF1","microtubule-actin crosslinking factor 1",TRUE
+"215222_x_at",0.830635993561085,0.403828673293546,0.851081456811681,-5.59291132275261,0.568786267124475,"MACF1","microtubule-actin crosslinking factor 1",TRUE
+"214894_x_at",0.837067957688307,0.419557977207064,0.822497350161102,-5.61544894570461,0.550405563852239,"MACF1","microtubule-actin crosslinking factor 1",TRUE
+"208634_s_at",0.867972140419125,0.501465553318834,0.683356793352336,-5.71476055583568,0.542782308375159,"MACF1","microtubule-actin crosslinking factor 1",TRUE
+"1559731_x_at",0.581336273502073,0.0637553727802657,-1.95147849994961,-4.23768307673717,-1.18101525924684,"MACROD1","MACRO domain containing 1",TRUE
+"219188_s_at",0.782042580063933,0.303704790868274,-1.05296628921518,-5.41362160966131,-0.828092971897039,"MACROD1","MACRO domain containing 1",TRUE
+"1563209_a_at",0.772943317221533,0.283431499522109,-1.09931725112301,-5.36760995208844,-1.54970183105645,"MACROD2","MACRO domain containing 2",TRUE
+"235278_at",0.817511349657198,0.369900088136413,-0.915277926334157,-5.53968920273943,-1.11076772101691,"MACROD2","MACRO domain containing 2",TRUE
+"1561677_at",0.975449397348071,0.882825058059912,-0.14909801097711,-5.92886175854894,-0.120380625271419,"MACROD2","MACRO domain containing 2",TRUE
+"1553564_at",0.984090952208401,0.921867537311664,0.099205083633362,-5.9348911131454,0.0324715167471297,"MACROD2","MACRO domain containing 2",TRUE
+"1562943_at",0.875938621758472,0.524125318275978,0.647241737923521,-5.73767633969428,0.363903561351122,"MACROD2-AS1","MACROD2 antisense RNA 1",TRUE
+"204857_at",0.871744769522775,0.513706682564021,0.663736661255172,-5.72735783683175,0.275316102755742,"MAD1L1","MAD1 mitotic arrest deficient like 1",TRUE
+"203362_s_at",0.936318756756998,0.715701282818094,-0.368903624605936,-5.87361561907479,-0.108698942567884,"MAD2L1","MAD2 mitotic arrest deficient-like 1 (yeast)",TRUE
+"236312_at",0.986892496508412,0.939625064727444,-0.0766053162824982,-5.93682561606184,-0.0244010717394598,"MAD2L1","MAD2 mitotic arrest deficient-like 1 (yeast)",TRUE
+"1554768_a_at",0.992649913032249,0.965556778523475,-0.0436723473708772,-5.93875456063718,-0.0151708581883288,"MAD2L1","MAD2 mitotic arrest deficient-like 1 (yeast)",TRUE
+"203094_at",0.991367768700244,0.959602958146807,-0.0512279005280278,-5.93840536288322,-0.0147804851259625,"MAD2L1BP","MAD2L1 binding protein",TRUE
+"223234_at",0.909052380289506,0.622434792199202,0.499379289176947,-5.81894437016746,0.179779523045667,"MAD2L2","MAD2 mitotic arrest deficient-like 2 (yeast)",TRUE
+"208037_s_at",0.728156825353177,0.208378947691962,1.29580735049779,-5.15335297315612,0.462842350059786,"MADCAM1","mucosal vascular addressin cell adhesion molecule 1",TRUE
+"210252_s_at",0.673366993714442,0.139596147264244,-1.53232968599596,-4.85650214940702,-0.537109815171242,"MADD","MAP kinase activating death domain",TRUE
+"38398_at",0.879960488971225,0.535093206643587,-0.630070146352891,-5.74815308267742,-0.200016610144345,"MADD","MAP kinase activating death domain",TRUE
+"207922_s_at",0.86679822545543,0.498152600770339,-0.688713118602266,-5.71126051148647,-0.252547271726581,"MAEA","macrophage erythroblast attacher",TRUE
+"229475_at",0.879419229950485,0.533549975966534,0.632474650278812,-5.74670235632263,0.714648527198475,"MAEL","maelstrom spermatogenic transposon silencer",TRUE
+"209348_s_at",0.494184691388595,0.0300171442176776,-2.31876001761455,-3.61352564726657,-1.52607917699611,"MAF","MAF bZIP transcription factor",TRUE
+"229327_s_at",0.725181883744124,0.203775913202773,-1.3095186776836,-5.1372753132026,-1.30450595464564,"MAF","MAF bZIP transcription factor",TRUE
+"1566323_at",0.744688669253745,0.236027532977551,1.2180226945804,-5.24181914240386,1.13416133677203,"MAF","MAF bZIP transcription factor",TRUE
+"209347_s_at",0.90115698600215,0.59764998189525,0.535483585065301,-5.80097853110945,0.241889175831344,"MAF","MAF bZIP transcription factor",TRUE
+"1566324_a_at",0.957174671135192,0.806060798774466,0.24846803336594,-5.9096586289324,0.249080118073803,"MAF","MAF bZIP transcription factor",TRUE
+"206363_at",0.957390359236635,0.807027530122973,-0.247202758959154,-5.90996319340513,-0.159575726858576,"MAF","MAF bZIP transcription factor",TRUE
+"222998_at",0.843753336849204,0.43936332157886,0.787446739810714,-5.64209940713297,0.347946323922546,"MAF1","MAF1 homolog, negative regulator of RNA polymerase III",TRUE
+"222670_s_at",0.588467901034655,0.0671020946511273,-1.92545968218277,-4.27921181373671,-1.28611960812708,"MAFB","MAF bZIP transcription factor B",TRUE
+"218559_s_at",0.623503825356688,0.0941201231599359,-1.74907224406388,-4.55028213935972,-2.12779827150431,"MAFB","MAF bZIP transcription factor B",TRUE
+"205193_at",0.395361429351355,0.0135511169383528,2.68252497903585,-2.93605852983423,1.48595582314211,"MAFF","MAF bZIP transcription factor F",TRUE
+"36711_at",0.429276772897071,0.0188043517219216,2.53503826364367,-3.21689005783228,2.65755164108385,"MAFF","MAF bZIP transcription factor F",TRUE
+"224466_s_at",0.895999830738594,0.576910728134159,0.56625624011539,-5.78470383614154,0.389925765093295,"MAFG","MAF bZIP transcription factor G",TRUE
+"204970_s_at",0.981848698003052,0.91310793870273,0.110372082181145,-5.93375182067667,0.0559713451156849,"MAFG","MAF bZIP transcription factor G",TRUE
+"1559352_a_at",0.985031563903634,0.926154871615805,0.0937442586465754,-5.93540408303269,0.0597753001496919,"MAFG-AS1","MAFG antisense RNA 1 (head to head)",TRUE
+"226206_at",0.674438494582062,0.140832179548612,1.52731888455443,-4.86320793563064,0.483309790255452,"MAFK","MAF bZIP transcription factor K",TRUE
+"206750_at",0.83030603167465,0.402662766322485,0.85322820713101,-5.59118967607604,0.403982739478871,"MAFK","MAF bZIP transcription factor K",TRUE
+"216617_s_at",0.908882763411412,0.621517389463447,0.500703469341259,-5.81830704389743,0.396000759130385,"MAG","myelin associated glycoprotein",TRUE
+"217447_at",0.954560978073101,0.791670188399172,-0.267353051300364,-5.90492919172481,-0.0916531549754867,"MAG","myelin associated glycoprotein",TRUE
+"207325_x_at",0.534566721281704,0.0424951636320509,2.15262832062848,-3.90422214495297,2.92431916059454,"MAGEA1","MAGE family member A1",TRUE
+"210295_at",0.677013732819214,0.14373805185132,1.51567938563586,-4.8787171809173,1.35968371921875,"MAGEA10","MAGE family member A10",TRUE
+"214642_x_at",0.301074390388992,0.00574340355145347,3.05717037202401,-2.19192461322293,3.75411651217106,"MAGEA10-MAGEA5///MAGEA5","MAGEA10-MAGEA5 readthrough///MAGE family member A5",TRUE
+"1553585_a_at",0.849376388324004,0.450437464644801,0.768271209062423,-5.65621684581363,0.447398082222852,"MAGEA10-MAGEA5///MAGEA5","MAGEA10-MAGEA5 readthrough///MAGE family member A5",TRUE
+"210503_at",0.327013625587277,0.0075420975192603,2.93983210694338,-2.42916880588807,2.7591123275676,"MAGEA11","MAGE family member A11",TRUE
+"210467_x_at",0.41173827666364,0.0163866939189773,2.59735230728689,-3.09918764178133,4.55925929963153,"MAGEA12","MAGE family member A12",TRUE
+"1553830_s_at",0.411110107932987,0.0160205137308117,2.60753397885295,-3.07982098627349,5.33598808957886,"MAGEA2B///MAGEA2","MAGE family member A2B///MAGE family member A2",TRUE
+"214603_at",0.424010380516768,0.0178851122623599,2.5577961592611,-3.17407036518438,4.48097268418411,"MAGEA2B///MAGEA2","MAGE family member A2B///MAGE family member A2",TRUE
+"214254_at",0.000106040515687987,3.87893975996295e-09,9.33711320476424,9.79992442024776,5.5656722408966,"MAGEA4","MAGE family member A4",TRUE
+"214612_x_at",0.413584432973372,0.0166307637659963,2.59068382491111,-3.11185159568353,5.91330006944371,"MAGEA6","MAGE family member A6",TRUE
+"209942_x_at",0.40221114169538,0.0144996098750645,2.6523071028225,-2.99422201049413,5.88541530817104,"MAGEA6///MAGEA3","MAGE family member A6///MAGE family member A3",TRUE
+"210274_at",0.887044556660952,0.551257429286252,-0.605104407180853,-5.7629011395871,-0.746900808208755,"MAGEA8","MAGE family member A8",TRUE
+"210437_at",0.274882222151803,0.004402760983568,3.17050750447479,-1.95970912757629,2.50354452826139,"MAGEA9B///MAGEA9","MAGE family member A9B///MAGE family member A9",TRUE
+"207534_at",0.525020012390103,0.0391592429908887,2.19216950451909,-3.8362234972721,1.57456381166795,"MAGEB1","MAGE family member B1",TRUE
+"1552913_at",0.608709711882903,0.08142830761469,1.8255483717722,-4.43504496847197,2.13097696087201,"MAGEB18","MAGE family member B18",TRUE
+"206218_at",0.624520459874487,0.0961415520278016,1.73772165946091,-4.56707682686649,0.6046120635586,"MAGEB2","MAGE family member B2",TRUE
+"207579_at",0.929786324276714,0.690161981254357,0.403894698412832,-5.86053925755775,0.288999956063006,"MAGEB3","MAGE family member B3",TRUE
+"207580_at",0.755049574909504,0.249073143723234,1.18370815148753,-5.27934080205964,1.33024927984165,"MAGEB4","MAGE family member B4",TRUE
+"207581_s_at",0.801086839730802,0.337335379942328,0.98068590346318,-5.481804532223,0.478138009311995,"MAGEB4","MAGE family member B4",TRUE
+"1552858_at",0.767965891104819,0.270969589079869,-1.12901016350993,-5.33720891730716,-0.550298194281068,"MAGEB6","MAGE family member B6",TRUE
+"206609_at",0.0552282326235679,0.000104883964970825,4.70958332014557,1.33011510157025,3.71237028263996,"MAGEC1","MAGE family member C1",TRUE
+"220062_s_at",0.0523352093161926,7.59402234548495e-05,4.8418108898969,1.61341306924712,3.48181083170032,"MAGEC2","MAGE family member C2",TRUE
+"215932_at",0.553474071458171,0.0505035599909431,2.06807397231051,-4.04699539924935,1.45345664160731,"MAGEC2","MAGE family member C2",TRUE
+"216592_at",0.925511384407886,0.678006176491774,0.420728436554084,-5.85383309470685,0.301970883970963,"MAGEC3","MAGE family member C3",TRUE
+"209014_at",0.948308225054417,0.76463041795197,-0.303114380042829,-5.89503174862348,-0.273329967315151,"MAGED1","MAGE family member D1",TRUE
+"208682_s_at",0.51531387545335,0.0358523036970486,-2.23450710175126,-3.76257616348962,-1.37026334932222,"MAGED2","MAGE family member D2",TRUE
+"213627_at",0.522688200326889,0.0385898206862205,-2.1992221595008,-3.82401489224797,-1.70303477372294,"MAGED2","MAGE family member D2",TRUE
+"229286_at",0.670409852865276,0.136144978874983,-1.54651643631714,-4.83742206851898,-1.43189299910946,"MAGEE1","MAGE family member E1",TRUE
+"1556047_s_at",0.924812035112346,0.674863125220732,-0.42510102358531,-5.85204711456993,-0.274552655785391,"MAGEE1","MAGE family member E1",TRUE
+"1553254_at",0.888691537652564,0.555092907222181,-0.599237547135161,-5.76628340786792,-0.348429043252366,"MAGEE2","MAGE family member E2",TRUE
+"218176_at",0.647754107214051,0.119212226138594,-1.62077368305575,-4.73530623091642,-0.618781187675459,"MAGEF1","MAGE family member F1",TRUE
+"218573_at",0.726480797733202,0.205397333333875,-1.30466167785772,-5.14298694256399,-1.28346002938693,"MAGEH1","MAGE family member H1",TRUE
+"219894_at",0.571677937624457,0.0594797340981734,1.98653297892278,-4.18113228666323,0.976049580837068,"MAGEL2","MAGE family member L2",TRUE
+"222372_at",0.615637099066718,0.0861257753099926,-1.79611746862512,-4.47981719697688,-1.37593364044385,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"225474_at",0.642592458809121,0.112682977064946,-1.65177813145127,-4.69157436835253,-0.870190553063573,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"1563881_at",0.703902004301726,0.17561421844133,-1.39914247798498,-5.02869500948934,-1.30304267589196,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"1559256_at",0.755685495730197,0.249930107130331,1.18150164725691,-5.28172157865048,0.614646818760288,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"1566538_at",0.769847953580141,0.27789808595146,1.11238188981902,-5.35432223069148,0.781755532336165,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"215372_x_at",0.784552021081681,0.3082916943352,-1.04278744214469,-5.42348797992341,-0.387086476185993,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"1566539_at",0.830592576740524,0.403137268052553,-0.852354041339417,-5.59189122578539,-0.870190550045443,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"1559257_a_at",0.854092692629534,0.463423311085847,0.746145324160903,-5.67209757483327,0.269607669218495,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"232859_s_at",0.899331416659389,0.590088030625544,-0.546641872563277,-5.79517931174874,-0.257977127541954,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"206144_at",0.91249313740935,0.63339021229705,-0.483635108449143,-5.82639568296721,-0.18312774031542,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"225465_at",0.925511384407886,0.678272837163488,-0.42035784516436,-5.85398362811178,-0.139247390721081,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"1555262_a_at",0.95018792835023,0.77372321459681,-0.291046018410458,-5.8985094519259,-0.214294183824753,"MAGI1","membrane associated guanylate kinase, WW and PDZ domain containing 1",TRUE
+"1561301_at",0.818686885011389,0.372277180209325,-0.910657346633586,-5.54363941718024,-0.502006420365463,"MAGI1-IT1","MAGI1 intronic transcript 1",TRUE
+"207702_s_at",0.656693876264681,0.124809883956021,-1.59530572897816,-4.77074963861681,-1.55672709929763,"MAGI2","membrane associated guanylate kinase, WW and PDZ domain containing 2",TRUE
+"209737_at",0.711977799428804,0.185842799587704,-1.36536096296872,-5.07032604391686,-0.735773489190348,"MAGI2","membrane associated guanylate kinase, WW and PDZ domain containing 2",TRUE
+"237786_at",0.723009970036937,0.199810336106708,1.3215256754114,-5.12307862906437,0.907934523882201,"MAGI2","membrane associated guanylate kinase, WW and PDZ domain containing 2",TRUE
+"241146_at",0.433044987283824,0.019468213602993,2.5192403913972,-3.24649906090915,1.83920275717805,"MAGI2-AS2","MAGI2 antisense RNA 2",TRUE
+"229480_at",0.871744769522775,0.513682320013861,-0.663775448326253,-5.72733327993201,-0.577362606186025,"MAGI2-AS3","MAGI2 antisense RNA 3",TRUE
+"227554_at",0.955234687900581,0.795334993983621,0.262534513021249,-5.90616860742026,0.134634231607038,"MAGI2-AS3","MAGI2 antisense RNA 3",TRUE
+"235267_at",0.98539961718117,0.927824635095768,0.0916182618070834,-5.93559594548818,0.11840593862993,"MAGI2-AS3","MAGI2 antisense RNA 3",TRUE
+"1560526_at",0.698955864196462,0.170292530581588,-1.41734187531255,-5.00591855919651,-1.36610403949197,"MAGI2-IT1","MAGI2 intronic transcript 1",TRUE
+"226770_at",0.465258652136505,0.0239968797261078,-2.42320696532211,-3.42438537473358,-1.01381971942794,"MAGI3","membrane associated guanylate kinase, WW and PDZ domain containing 3",TRUE
+"224307_x_at",0.652139736047968,0.12130308982749,-1.61114613970061,-4.74875588961723,-0.509121845708344,"MAGI3","membrane associated guanylate kinase, WW and PDZ domain containing 3",TRUE
+"230409_at",0.967838702526368,0.84861796797648,0.193128206500646,-5.92153306583742,0.0679163778258731,"MAGI3","membrane associated guanylate kinase, WW and PDZ domain containing 3",TRUE
+"234927_s_at",0.748184017928985,0.240433372167572,-1.20627774414896,-5.25476661150678,-1.17100929279146,"MAGIX","MAGI family member, X-linked",TRUE
+"219965_s_at",0.792436690618566,0.323688280233099,-1.00938189653108,-5.45526041043632,-0.723535414566648,"MAGIX","MAGI family member, X-linked",TRUE
+"1563318_s_at",0.914242258486146,0.639247363481918,-0.475268555983738,-5.83026040150298,-0.157710413010811,"MAGIX","MAGI family member, X-linked",TRUE
+"1565559_at",0.954685039946564,0.793679208302991,0.264710770079578,-5.90561160700772,0.0903614792477931,"MAGIX","MAGI family member, X-linked",TRUE
+"222944_s_at",0.989475734766121,0.947968732697848,-0.0660012766113963,-5.93756197438868,-0.0524238695369834,"MAGIX","MAGI family member, X-linked",TRUE
+"217692_at",0.775351898377291,0.292087988238232,1.07924406310229,-5.38775352553996,0.5938485229994,"MAGOH2P","mago homolog 2, pseudogene",TRUE
+"217693_x_at",0.917102138198416,0.649276826698665,0.461021259227302,-5.83668965582801,0.154307671458479,"MAGOH2P","mago homolog 2, pseudogene",TRUE
+"222776_at",0.908351966956255,0.619074885133808,0.504233419231249,-5.8166000354082,0.28465655871762,"MAGOHB","mago homolog B, exon junction complex core component",TRUE
+"218894_s_at",0.956768941747255,0.804368379997336,0.250684099749117,-5.90912147495856,0.0913898486305182,"MAGOHB","mago homolog B, exon junction complex core component",TRUE
+"210092_at",0.980338871909347,0.908373979232299,0.116412972384551,-5.93308496575216,0.0421575903006861,"MAGOHB///MAGOH","mago homolog B, exon junction complex core component///mago homolog, exon junction complex core component",TRUE
+"210093_s_at",0.995366465678067,0.978271831727052,0.0275447616698515,-5.93931394594075,0.00936620000555344,"MAGOHB///MAGOH","mago homolog B, exon junction complex core component///mago homolog, exon junction complex core component",TRUE
+"224899_s_at",0.823074246722209,0.389459233618234,-0.877823621987821,-5.5711768184044,-0.240038053940809,"MAGT1","magnesium transporter 1",TRUE
+"210596_at",0.929234395612144,0.688982121915824,0.405523333146903,-5.85990221986138,0.141983140561111,"MAGT1","magnesium transporter 1",TRUE
+"221553_at",0.980561931836093,0.909183120885793,0.11538013837631,-5.9332014950734,0.039290715819936,"MAGT1","magnesium transporter 1",TRUE
+"231210_at",0.731314021977412,0.214443828332271,1.27809518523274,-5.17390902827193,0.669870619694559,"MAJIN","membrane anchored junction protein",TRUE
+"220302_at",0.4180749314337,0.0170991512392658,2.57813962333187,-3.13563024619092,2.22567903073831,"MAK","male germ cell associated kinase",TRUE
+"1555315_a_at",0.743553048228796,0.234319506556601,1.22262046124934,-5.23672105320734,0.943583149502034,"MAK","male germ cell associated kinase",TRUE
+"211686_s_at",0.848268984089208,0.448072636881042,0.772341738743313,-5.65324748794006,0.291633354022085,"MAK16","MAK16 homolog",TRUE
+"204777_s_at",0.432151440378733,0.0193727147758258,2.52148171503934,-3.24230408368232,2.77109421467721,"MAL","mal, T-cell differentiation protein",TRUE
+"224650_at",0.732963666545614,0.21738808660018,1.26963563302295,-5.18364174298846,1.62582062925604,"MAL2","mal, T-cell differentiation protein 2 (gene/pseudogene)",TRUE
+"224558_s_at",0.739189560382301,0.226313160755753,-1.24451772770876,-5.21221362174656,-0.705768815824321,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"226675_s_at",0.808811461484454,0.351993487598702,-0.950738819334908,-5.50876128412208,-0.752716492500573,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"224567_x_at",0.897197013608397,0.583280619089355,-0.556747120696349,-5.78982714091395,-0.407224370820051,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"223577_x_at",0.920147736488699,0.660108555929309,-0.445742262279415,-5.84337138395257,-0.23978777791433,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"1558678_s_at",0.927973182663162,0.683888653469698,-0.412567062479008,-5.85711802947989,-0.318699247189569,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"223940_x_at",0.94943075115007,0.771656764547037,-0.293784764463857,-5.89773252429719,-0.293562198996446,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"228582_x_at",0.949613960042259,0.772221160984493,-0.293036521212428,-5.89794550248138,-0.199773082701935,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"223578_x_at",0.961212424803935,0.823790732265292,0.225326328939718,-5.91498454543452,0.224657789023254,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"224568_x_at",0.961778365989609,0.826698419534479,-0.221543439410046,-5.9158059287913,-0.241391135137436,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"231735_s_at",0.96863865991453,0.852480716590528,-0.18813825685085,-5.92245808295348,-0.11481720254665,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"227510_x_at",0.983212176432519,0.918212434932456,-0.10386306299317,-5.93443063528253,-0.0912991358111288,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"224559_at",0.98672253748883,0.938127283482153,-0.0785097765271404,-5.93668177419597,-0.0655454271736513,"MALAT1","metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)",TRUE
+"209373_at",0.407748633394319,0.0155251186523669,2.62166192661414,-3.05288676673689,2.97625049572873,"MALL","mal, T-cell differentiation protein like",TRUE
+"242660_at",0.909052380289506,0.622143930323625,0.49979902146308,-5.81874253188198,0.538985182111664,"MALRD1","MAM and LDL receptor class A domain containing 1",TRUE
+"230516_at",0.702621412021935,0.174017708202724,1.40455551832118,-5.02194596030453,1.01570082225254,"MALSU1","mitochondrial assembly of ribosomal large subunit 1",TRUE
+"226386_at",0.740610299769501,0.230322295768955,1.23348048709199,-5.22461338940505,0.442663015004976,"MALSU1","mitochondrial assembly of ribosomal large subunit 1",TRUE
+"226385_s_at",0.821187434813103,0.382376229607869,0.891241278747199,-5.56003661802702,0.281712064942198,"MALSU1","mitochondrial assembly of ribosomal large subunit 1",TRUE
+"244641_at",0.873968636108443,0.519808363677708,0.654054242384066,-5.73344493190738,0.191899735264186,"MALSU1","mitochondrial assembly of ribosomal large subunit 1",TRUE
+"210018_x_at",0.819162667476514,0.37549723995328,0.90442926789997,-5.5489347089213,0.498726206913419,"MALT1","MALT1 paracaspase",TRUE
+"208309_s_at",0.822173415758858,0.386489012364717,0.883430695981791,-5.56654052061988,0.513762100229425,"MALT1","MALT1 paracaspase",TRUE
+"210017_at",0.960699983781935,0.821560931985828,-0.228229566820735,-5.91434477628152,-0.145639055447235,"MALT1","MALT1 paracaspase",TRUE
+"228885_at",0.480157585403077,0.0270310936967658,2.36787793979875,-3.52516236752942,2.65252933949586,"MAMDC2","MAM domain containing 2",TRUE
+"1559655_at",0.391326002716224,0.0131799576794235,2.69489585492097,-2.91215815437387,1.46294523659433,"MAMDC2-AS1","MAMDC2 antisense RNA 1",TRUE
+"1559656_a_at",0.786455312223125,0.312087784605481,1.03444418454898,-5.43151078006384,0.644150940393442,"MAMDC2-AS1","MAMDC2 antisense RNA 1",TRUE
+"229473_at",0.6708432030569,0.136423902326338,-1.54535892329419,-4.83898404919402,-1.2982474970023,"MAMDC4","MAM domain containing 4",TRUE
+"202360_at",0.643082025527735,0.113425882251748,-1.64817541675183,-4.69668862851329,-0.483777269903793,"MAML1","mastermind like transcriptional coactivator 1",TRUE
+"235457_at",0.51470556386048,0.0352028579033195,2.24323724666742,-3.74728398687297,2.76617230717642,"MAML2","mastermind like transcriptional coactivator 2",TRUE
+"235106_at",0.520481716530016,0.0377409469139851,2.20991342176711,-3.80546188866899,1.69757308105838,"MAML2","mastermind like transcriptional coactivator 2",TRUE
+"242794_at",0.437104227425433,0.0199784812864409,-2.50743565479587,-3.26856153113232,-1.53680589613174,"MAML3","mastermind like transcriptional coactivator 3",TRUE
+"207946_at",0.68033297785336,0.147647555102983,1.50032025013205,-4.89903760516199,0.988545910494277,"MAML3","mastermind like transcriptional coactivator 3",TRUE
+"228508_at",0.869060996512026,0.505593579975875,-0.67671061203103,-5.7190671226107,-0.255627168817987,"MAML3","mastermind like transcriptional coactivator 3",TRUE
+"205088_at",0.849189309967511,0.450027113386609,0.768976607876391,-5.65570333494792,0.685188689839102,"MAMLD1","mastermind like domain containing 1",TRUE
+"1557091_at",0.79476249846508,0.326902208752822,1.00254958033756,-5.46164340949685,0.428131430595762,"MAMSTR","MEF2 activating motif and SAP domain containing transcriptional regulator",TRUE
+"221760_at",0.945432830098469,0.753346597369513,0.318155148026649,-5.89050153790705,0.440903106792227,"MAN1A1","mannosidase alpha class 1A member 1",TRUE
+"208116_s_at",0.951339758531576,0.777479916423711,0.286072916086685,-5.89990176830418,0.286832035594617,"MAN1A1","mannosidase alpha class 1A member 1",TRUE
+"217282_at",0.711989638658417,0.186076490520345,1.36460655878411,-5.07124608482704,0.773662636472028,"MAN1A2","mannosidase alpha class 1A member 2",TRUE
+"217921_at",0.836802432816621,0.418824352420618,-0.823815317644818,-5.61442560894172,-0.415289998917494,"MAN1A2","mannosidase alpha class 1A member 2",TRUE
+"217920_at",0.901507587832957,0.598317436482753,-0.534502016513539,-5.80148310948749,-0.275719430829044,"MAN1A2","mannosidase alpha class 1A member 2",TRUE
+"214242_at",0.910159094731364,0.625886929257999,-0.494404545379337,-5.82132398337361,-0.389222344731053,"MAN1A2","mannosidase alpha class 1A member 2",TRUE
+"217922_at",0.961285315706981,0.824446109266241,-0.224473394519289,-5.91517095253083,-0.103761198437889,"MAN1A2","mannosidase alpha class 1A member 2",TRUE
+"1552481_s_at",0.971242929121865,0.863316162911322,-0.174166503420282,-5.92491971274981,-0.112054166796408,"MAN1A2","mannosidase alpha class 1A member 2",TRUE
+"218636_s_at",0.710657275720264,0.18358981836405,-1.37267280373062,-5.06138687911111,-0.448750965944033,"MAN1B1","mannosidase alpha class 1B member 1",TRUE
+"65884_at",0.812302873476553,0.35974623267172,-0.935240723664992,-5.52241113167197,-0.300544390029467,"MAN1B1","mannosidase alpha class 1B member 1",TRUE
+"232420_x_at",0.136521382439662,0.000883924451461189,-3.83880503040752,-0.547762279352198,-2.08175567334082,"MAN1B1-AS1","MAN1B1 antisense RNA 1 (head to head)",TRUE
+"218918_at",0.518874125067442,0.0372729363078115,-2.21590164535308,-3.79504631539602,-2.89227247668838,"MAN1C1","mannosidase alpha class 1C member 1",TRUE
+"214180_at",0.697152783882664,0.166730128981248,-1.42978077354496,-4.99021227771971,-0.597722637803536,"MAN1C1","mannosidase alpha class 1C member 1",TRUE
+"205105_at",0.7717895132349,0.281190527343021,1.10458579053071,-5.36226822432321,0.501522020601968,"MAN2A1","mannosidase alpha class 2A member 1",TRUE
+"226538_at",0.789406360796076,0.316169118938106,1.02555335669409,-5.43999615845447,0.482880558045006,"MAN2A1","mannosidase alpha class 2A member 1",TRUE
+"235103_at",0.858465170616586,0.474224481904577,0.728021774257482,-5.68477789296937,0.294453243623735,"MAN2A1","mannosidase alpha class 2A member 1",TRUE
+"219999_at",0.711977799428804,0.185693791280411,-1.36584238495434,-5.06973869957737,-0.709179477916775,"MAN2A2","mannosidase alpha class 2A member 2",TRUE
+"202032_s_at",0.774230543658252,0.286347527044617,-1.09250660276932,-5.37448154469807,-0.5284028927825,"MAN2A2","mannosidase alpha class 2A member 2",TRUE
+"209166_s_at",0.884749233889577,0.544272129037944,0.615844798550686,-5.75662688316924,0.225673828760414,"MAN2B1","mannosidase alpha class 2B member 1",TRUE
+"214703_s_at",0.871451481476429,0.512689932027155,-0.665356278150709,-5.72633125370387,-0.260917879774748,"MAN2B2","mannosidase alpha class 2B member 2",TRUE
+"238230_x_at",0.410263142293979,0.0158857822796596,-2.61133525322717,-3.07258102961216,-1.06166029648438,"MAN2C1","mannosidase alpha class 2C member 1",TRUE
+"238089_at",0.676468346171966,0.143258463676529,-1.51758700071913,-4.8761818274906,-0.570648583565574,"MAN2C1","mannosidase alpha class 2C member 1",TRUE
+"203668_at",0.943464796017993,0.746945716677633,-0.326720380356597,-5.88782466084851,-0.102216628464133,"MAN2C1","mannosidase alpha class 2C member 1",TRUE
+"203778_at",0.724697226571437,0.202282831622071,-1.31401789328704,-5.13196840950099,-0.54575806531745,"MANBA","mannosidase beta",TRUE
+"224689_at",0.959515701539076,0.817024278619763,0.234142592921098,-5.91301655930116,0.110374288232537,"MANBAL","mannosidase beta like",TRUE
+"1554193_s_at",0.609970971583967,0.0820386265473822,1.82164275556373,-4.44101663655891,0.485362047629359,"MANEA","mannosidase endo-alpha",TRUE
+"222805_at",0.627092759817312,0.0984942170488122,1.72476527323037,-4.58614826762713,0.628908836031648,"MANEA","mannosidase endo-alpha",TRUE
+"219003_s_at",0.685360765794715,0.153991997001426,1.47608719302128,-4.93076014307773,0.587437253004946,"MANEA","mannosidase endo-alpha",TRUE
+"1555227_a_at",0.717552284196685,0.193302745202249,1.3416390766738,-5.09905281088711,0.760049553211992,"MANEA","mannosidase endo-alpha",TRUE
+"226132_s_at",0.562414216355319,0.0550056989164414,-2.02569237749076,-4.11716017369717,-1.02181999004106,"MANEAL","mannosidase endo-alpha like",TRUE
+"231564_at",0.972819824894874,0.868486777386519,-0.167511920789066,-5.92602560506587,-0.0805237741720628,"MANEAL","mannosidase endo-alpha like",TRUE
+"202655_at",0.919481699308214,0.657880139973355,-0.448876703385246,-5.84201864877018,-0.178657639801957,"MANF","mesencephalic astrocyte derived neurotrophic factor",TRUE
+"220945_x_at",0.988065316951061,0.943100626087596,-0.07218717305118,-5.93714571933156,-0.0354342143037858,"MANSC1","MANSC domain containing 1",TRUE
+"204389_at",0.545992239117952,0.047229351182497,2.10107516364876,-3.99170695810737,1.6458550496281,"MAOA","monoamine oxidase A",TRUE
+"212741_at",0.55937703282623,0.0531259960294224,2.04299622810852,-4.0886281295189,2.01390610604016,"MAOA","monoamine oxidase A",TRUE
+"204388_s_at",0.65284137151906,0.122104819779256,1.60749128957337,-4.75384546084112,1.8028219794743,"MAOA","monoamine oxidase A",TRUE
+"1561010_a_at",0.873659675709122,0.519124545238857,-0.655136216542273,-5.73276897967588,-0.378152097634438,"MAOB","monoamine oxidase B",TRUE
+"1561009_at",0.934048461921637,0.707894585573283,0.379547762193555,-5.86976140421413,0.337631369649676,"MAOB","monoamine oxidase B",TRUE
+"204041_at",0.934200936091995,0.708680410150946,0.378474317175687,-5.87015499877058,0.3837321409057,"MAOB","monoamine oxidase B",TRUE
+"232039_at",0.755049574909504,0.248968088597936,1.18397903682023,-5.27904825474397,0.89184497348251,"MAP10","microtubule associated protein 10",TRUE
+"215391_at",0.657318133823516,0.126173823767312,1.58924484207056,-4.77912019967878,1.11954347205186,"MAP1A","microtubule associated protein 1A",TRUE
+"215384_s_at",0.865885012497452,0.496227567294056,0.69183478282266,-5.70920864826482,0.411152685630171,"MAP1A","microtubule associated protein 1A",TRUE
+"203151_at",0.993846586666397,0.970906771533832,-0.0368853016093314,-5.9390208406786,-0.0166207665236877,"MAP1A","microtubule associated protein 1A",TRUE
+"214577_at",0.66932922090261,0.135445057157137,1.54942970135066,-4.83348673604536,1.97083240598451,"MAP1B","microtubule associated protein 1B",TRUE
+"212233_at",0.70939075283402,0.182281504701235,1.37695146395845,-5.05613754281922,1.25883001229383,"MAP1B","microtubule associated protein 1B",TRUE
+"226084_at",0.810921693906553,0.354930403890507,0.944840962978079,-5.51398003630387,1.47291588793556,"MAP1B","microtubule associated protein 1B",TRUE
+"227219_x_at",0.856857560656867,0.471283930439011,-0.732931426005885,-5.68137203054792,-0.580461721282936,"MAP1LC3A","microtubule associated protein 1 light chain 3 alpha",TRUE
+"232011_s_at",0.947778780715578,0.762018684894552,-0.306589219059668,-5.89400444905975,-0.314339196307548,"MAP1LC3A","microtubule associated protein 1 light chain 3 alpha",TRUE
+"224378_x_at",0.975398143273847,0.881794964202698,-0.150419071341545,-5.92866924546088,-0.120939552938779,"MAP1LC3A","microtubule associated protein 1 light chain 3 alpha",TRUE
+"208786_s_at",0.717937808890208,0.193767526184177,-1.34018510372059,-5.10079983030372,-0.411197037762378,"MAP1LC3B","microtubule associated protein 1 light chain 3 beta",TRUE
+"208785_s_at",0.897011777275924,0.582219299747629,-0.558327861230966,-5.78898130604735,-0.159679223131354,"MAP1LC3B","microtubule associated protein 1 light chain 3 beta",TRUE
+"234238_at",0.969882914559333,0.857298967587368,0.181920805431027,-5.92357688273169,0.131651939529785,"MAP1LC3B2","microtubule associated protein 1 light chain 3 beta 2",TRUE
+"221697_at",0.358427723880268,0.00987482987447348,-2.82241551003727,-2.66292724378053,-1.56082278571613,"MAP1LC3C","microtubule associated protein 1 light chain 3 gamma",TRUE
+"218522_s_at",0.843452046162121,0.438132264527671,0.789596557106388,-5.64049622132858,0.285320339255172,"MAP1S","microtubule associated protein 1S",TRUE
+"210015_s_at",0.728385463227073,0.20981638801166,1.29157370739278,-5.1582882538883,0.580060915711189,"MAP2","microtubule associated protein 2",TRUE
+"225540_at",0.76029267756668,0.258710609600476,1.15921206643642,-5.3055536643429,1.1712028076516,"MAP2","microtubule associated protein 2",TRUE
+"202670_at",0.976422537443518,0.888075719103636,-0.142368384292627,-5.92981613587355,-0.0546410581643819,"MAP2K1","mitogen-activated protein kinase kinase 1",TRUE
+"213490_s_at",0.819018525257656,0.374133476900026,-0.90706266189903,-5.54669981575269,-0.32890040318822,"MAP2K2","mitogen-activated protein kinase kinase 2",TRUE
+"213487_at",0.873230718105642,0.517801265372879,-0.657232217693723,-5.73145647534747,-0.314504373234792,"MAP2K2","mitogen-activated protein kinase kinase 2",TRUE
+"202424_at",0.930708572679794,0.693090630914138,-0.399856885050334,-5.86210775597444,-0.157690085885726,"MAP2K2","mitogen-activated protein kinase kinase 2",TRUE
+"203265_s_at",0.9203628665929,0.661051482471618,0.444417328871545,-5.84394039125496,0.286943502055761,"MAP2K4","mitogen-activated protein kinase kinase 4",TRUE
+"203266_s_at",0.925091998149497,0.675981007707057,0.423544873453909,-5.85268480318615,0.326715063748042,"MAP2K4","mitogen-activated protein kinase kinase 4",TRUE
+"204756_at",0.296656068775839,0.00537697602481676,-3.08537818394737,-2.13439620520288,-1.34417215990811,"MAP2K5","mitogen-activated protein kinase kinase 5",TRUE
+"210482_x_at",0.433660982257499,0.0195994505521136,-2.51617698317015,-3.25222957628111,-1.75768089428121,"MAP2K5","mitogen-activated protein kinase kinase 5",TRUE
+"211370_s_at",0.552420073963858,0.0497826868449583,-2.07517153926593,-4.03515231514475,-0.706885150576873,"MAP2K5","mitogen-activated protein kinase kinase 5",TRUE
+"211371_at",0.830635993561085,0.404383694194407,0.850060906598507,-5.59372836366498,0.577650306431359,"MAP2K5","mitogen-activated protein kinase kinase 5",TRUE
+"216435_at",0.866101014859131,0.496881399782101,0.690773745742644,-5.70990705974658,0.564832707060299,"MAP2K5","mitogen-activated protein kinase kinase 5",TRUE
+"216765_at",0.902798091581094,0.602360756851913,-0.528567148521539,-5.80451475740543,-0.462413564106836,"MAP2K5","mitogen-activated protein kinase kinase 5",TRUE
+"205699_at",0.921727601757524,0.666020244997814,0.437448839812354,-5.84690572274765,0.190409590158547,"MAP2K6","mitogen-activated protein kinase kinase 6",TRUE
+"205698_s_at",0.942961933269639,0.744199071091581,-0.330403378776415,-5.88665198140284,-0.205796894334612,"MAP2K6","mitogen-activated protein kinase kinase 6",TRUE
+"209951_s_at",0.497725944448536,0.0306339679156584,2.30917657116292,-3.63064228168498,0.927906203456553,"MAP2K7","mitogen-activated protein kinase kinase 7",TRUE
+"226023_at",0.526253358601247,0.0396167606621545,2.18656994556479,-3.84589953207107,0.737383799267146,"MAP2K7","mitogen-activated protein kinase kinase 7",TRUE
+"226053_at",0.643082025527735,0.113633423398892,1.64717249746403,-4.69811081003648,0.570064771091328,"MAP2K7","mitogen-activated protein kinase kinase 7",TRUE
+"209952_s_at",0.748632141741128,0.241561376215766,1.20329685694895,-5.25803538323141,0.754932301977863,"MAP2K7","mitogen-activated protein kinase kinase 7",TRUE
+"216206_x_at",0.951810226174863,0.779291449227264,0.283677456495349,-5.90056392816311,0.222321819386643,"MAP2K7","mitogen-activated protein kinase kinase 7",TRUE
+"214786_at",0.554642754132296,0.050916052368133,-2.06405335076708,-4.0536925450401,-1.21999373720671,"MAP3K1","mitogen-activated protein kinase kinase kinase 1",TRUE
+"225927_at",0.703902004301726,0.1756459224768,-1.39903538208907,-5.02882832104925,-0.737328281970198,"MAP3K1","mitogen-activated protein kinase kinase kinase 1",TRUE
+"206362_x_at",0.812302873476553,0.360557322101746,-0.933632351665935,-5.52381589762719,-0.262181898241373,"MAP3K10","mitogen-activated protein kinase kinase kinase 10",TRUE
+"203652_at",0.746437759467951,0.238122860551257,-1.21241659209639,-5.24801279344385,-0.384058653608333,"MAP3K11","mitogen-activated protein kinase kinase kinase 11",TRUE
+"1558984_at",0.946257232656659,0.756474943509915,-0.313977861401348,-5.89178151207333,-0.116544798830327,"MAP3K11","mitogen-activated protein kinase kinase kinase 11",TRUE
+"205447_s_at",0.432151440378733,0.0193508572410928,-2.52199615331385,-3.24134096282085,-1.8836089281138,"MAP3K12","mitogen-activated protein kinase kinase kinase 12",TRUE
+"230921_s_at",0.552420073963858,0.049630938236664,-2.07667734390299,-4.03263632655849,-1.00117952501057,"MAP3K12","mitogen-activated protein kinase kinase kinase 12",TRUE
+"205448_s_at",0.6632621445622,0.131220971517683,-1.56728042385815,-4.80924597351748,-0.593704889284763,"MAP3K12","mitogen-activated protein kinase kinase kinase 12",TRUE
+"226190_at",0.773887727472977,0.285489359172663,1.0945057061904,-5.37246849304981,1.17489263305437,"MAP3K13","mitogen-activated protein kinase kinase kinase 13",TRUE
+"1562440_at",0.784124594631274,0.307178444239206,1.0452479577666,-5.42111089597248,0.702217029847379,"MAP3K13","mitogen-activated protein kinase kinase kinase 13",TRUE
+"226556_at",0.78578093265889,0.311274813197679,1.03622492925953,-5.42980330519159,1.0228455243229,"MAP3K13","mitogen-activated protein kinase kinase kinase 13",TRUE
+"206249_at",0.835289077598304,0.414422008417977,0.831754897162175,-5.60822847482361,0.607246347669824,"MAP3K13","mitogen-activated protein kinase kinase kinase 13",TRUE
+"229771_at",0.864079461576774,0.490827764478928,-0.700628271592158,-5.70338110047372,-0.574834550753612,"MAP3K13","mitogen-activated protein kinase kinase kinase 13",TRUE
+"233508_at",0.929125618312698,0.688201241335936,-0.406601845901669,-5.85947897273322,-0.256932978141313,"MAP3K13","mitogen-activated protein kinase kinase kinase 13",TRUE
+"211083_s_at",0.961146128665821,0.822628125570488,0.226839813919046,-5.91465204469312,0.252055715417246,"MAP3K13","mitogen-activated protein kinase kinase kinase 13",TRUE
+"205192_at",0.612420348961838,0.084290874007447,1.80744436442565,-4.46264822645577,1.19255168608521,"MAP3K14","mitogen-activated protein kinase kinase kinase 14",TRUE
+"1557783_at",0.833762648920706,0.411429652819034,0.837182044419352,-5.60396040465431,0.344325533674065,"MAP3K14-AS1","MAP3K14 antisense RNA 1",TRUE
+"242581_at",0.92996437978379,0.690621827347188,0.40326024480011,-5.86078673998963,0.219327135137283,"MAP3K15","mitogen-activated protein kinase kinase kinase 15",TRUE
+"1555804_a_at",0.739340500562926,0.22659660535873,-1.243732527899,-5.21309889369168,-0.528686002581753,"MAP3K19","mitogen-activated protein kinase kinase kinase 19",TRUE
+"221180_at",0.871744769522775,0.513453342034355,-0.664140049069247,-5.72710237641658,-0.30097339640793,"MAP3K19","mitogen-activated protein kinase kinase kinase 19",TRUE
+"1565131_x_at",0.632949074657601,0.103807670053989,-1.69644738207341,-4.62745984613838,-1.01016585433512,"MAP3K2","mitogen-activated protein kinase kinase kinase 2",TRUE
+"227073_at",0.755868740464627,0.250381997883279,-1.18034039572186,-5.28297298984989,-0.375431153124477,"MAP3K2","mitogen-activated protein kinase kinase kinase 2",TRUE
+"1565130_at",0.886023097762234,0.548322366775048,-0.609608462607505,-5.76028295262001,-0.386289758053031,"MAP3K2","mitogen-activated protein kinase kinase kinase 2",TRUE
+"221695_s_at",0.92654417487241,0.68056311309708,0.417177393629436,-5.85527015774189,0.149730580732946,"MAP3K2","mitogen-activated protein kinase kinase kinase 2",TRUE
+"226441_at",0.972819824894874,0.868284943718797,-0.167771533626432,-5.92598326655224,-0.0658378347600026,"MAP3K2","mitogen-activated protein kinase kinase kinase 2",TRUE
+"235011_at",0.978240571220736,0.894437737452952,-0.134223342330535,-5.93091240512083,-0.0356073454699359,"MAP3K2","mitogen-activated protein kinase kinase kinase 2",TRUE
+"226979_at",0.979588787486838,0.902101863563688,0.124423544858808,-5.93214596190516,0.0475422211460597,"MAP3K2","mitogen-activated protein kinase kinase kinase 2",TRUE
+"227131_at",0.804351886842858,0.343094339295422,-0.968816221191808,-5.49258030873858,-0.435380705322459,"MAP3K3","mitogen-activated protein kinase kinase kinase 3",TRUE
+"243505_at",0.8920930097751,0.563020832218008,0.587177363501629,-5.77313613447304,0.466979233492416,"MAP3K3","mitogen-activated protein kinase kinase kinase 3",TRUE
+"203514_at",0.988303773451367,0.944285601863275,-0.0706811695898378,-5.93725049016928,-0.0333166900966404,"MAP3K3","mitogen-activated protein kinase kinase kinase 3",TRUE
+"204089_x_at",0.467673691528294,0.0245743825459571,2.41219577159656,-3.44454366355827,0.772548052540733,"MAP3K4","mitogen-activated protein kinase kinase kinase 4",TRUE
+"216199_s_at",0.610455440146151,0.0831328280248952,1.81470321933331,-4.45160443871743,0.719574203121415,"MAP3K4","mitogen-activated protein kinase kinase kinase 4",TRUE
+"203836_s_at",0.62986301194198,0.100784078828335,1.71240589382711,-4.6042417254991,1.11651779778918,"MAP3K5","mitogen-activated protein kinase kinase kinase 5",TRUE
+"203837_at",0.671298718565642,0.137196584174315,1.54216250732015,-4.84329257739644,0.856338332599607,"MAP3K5","mitogen-activated protein kinase kinase kinase 5",TRUE
+"1552631_a_at",0.643515428391208,0.114012174293353,1.64534619284946,-4.70069888443677,0.503481389850536,"MAP3K6","mitogen-activated protein kinase kinase kinase 6",TRUE
+"219278_at",0.867972140419125,0.501554443383518,0.683213354158823,-5.71485392587847,0.63825577208214,"MAP3K6","mitogen-activated protein kinase kinase kinase 6",TRUE
+"229960_at",0.912738769907055,0.634368052244501,0.482235907982823,-5.82704660096408,0.336248187957726,"MAP3K6","mitogen-activated protein kinase kinase kinase 6",TRUE
+"211537_x_at",0.819479221404744,0.376619060088784,0.902267789561972,-5.55076461375833,0.276414374055365,"MAP3K7","mitogen-activated protein kinase kinase kinase 7",TRUE
+"211536_x_at",0.867924303277286,0.501197513074966,0.683789408898034,-5.71447883641042,0.197807737340765,"MAP3K7","mitogen-activated protein kinase kinase kinase 7",TRUE
+"206854_s_at",0.901788521024914,0.599483309699707,0.532788739305605,-5.80236166705254,0.149809907996341,"MAP3K7","mitogen-activated protein kinase kinase kinase 7",TRUE
+"206853_s_at",0.907964244160782,0.617843050590696,0.506016150986603,-5.81573349734308,0.146747686473677,"MAP3K7","mitogen-activated protein kinase kinase kinase 7",TRUE
+"221211_s_at",0.661974206478491,0.129547205577279,1.57448546216371,-4.79939993555677,1.55459708112195,"MAP3K7CL","MAP3K7 C-terminal like",TRUE
+"235421_at",0.834265235157814,0.412363290239928,0.835486058124581,-5.60529696597174,0.761769934147457,"MAP3K8","mitogen-activated protein kinase kinase kinase 8",TRUE
+"205027_s_at",0.861659105448003,0.48301690543703,0.713447132281855,-5.69476022080628,0.590137615884851,"MAP3K8","mitogen-activated protein kinase kinase kinase 8",TRUE
+"214969_at",0.902770867950228,0.602266090074401,0.52870588207233,-5.8044442656104,0.157240951683212,"MAP3K9","mitogen-activated protein kinase kinase kinase 9",TRUE
+"213927_at",0.91671872326659,0.647677761470326,0.463286245080603,-5.83568036476149,0.132370037393317,"MAP3K9","mitogen-activated protein kinase kinase kinase 9",TRUE
+"212566_at",0.906476756086155,0.61360985927462,0.512155229791644,-5.81272663389728,0.227650869963854,"MAP4","microtubule associated protein 4",TRUE
+"243_g_at",0.932081612113538,0.699619520430316,0.390879495283322,-5.8655394246187,0.162041123183243,"MAP4","microtubule associated protein 4",TRUE
+"200835_s_at",0.955051304714495,0.794854221668558,0.263166274969315,-5.90600738211002,0.227963843158518,"MAP4","microtubule associated protein 4",TRUE
+"235066_at",0.957932374330736,0.810638855533762,-0.242479823101057,-5.91108639725889,-0.0983311658489896,"MAP4","microtubule associated protein 4",TRUE
+"212567_s_at",0.97689149311934,0.889238982744029,-0.140878383231108,-5.93002149646842,-0.053485001164006,"MAP4","microtubule associated protein 4",TRUE
+"200836_s_at",0.98453870130544,0.924517061630889,0.095830001323401,-5.93521158012465,0.0277610652580318,"MAP4","microtubule associated protein 4",TRUE
+"33850_at",0.988802593747325,0.946176781272677,0.0682779868255193,-5.93741310425255,0.0324588993378665,"MAP4","microtubule associated protein 4",TRUE
+"214339_s_at",0.591331966259927,0.0688311952832663,-1.9124613746228,-4.29981427192121,-0.611868658297899,"MAP4K1","mitogen-activated protein kinase kinase kinase kinase 1",TRUE
+"206296_x_at",0.897949253801113,0.585806665967027,-0.552990549601257,-5.79182789696851,-0.278262110989719,"MAP4K1","mitogen-activated protein kinase kinase kinase kinase 1",TRUE
+"214219_x_at",0.913221029035633,0.635972636516887,0.479942005556782,-5.82810975063777,0.183229074926555,"MAP4K1","mitogen-activated protein kinase kinase kinase kinase 1",TRUE
+"204936_at",0.995375928428862,0.978539692231582,-0.0272051072549606,-5.93932300305648,-0.0215280770736062,"MAP4K2","mitogen-activated protein kinase kinase kinase kinase 2",TRUE
+"218311_at",0.767965891104819,0.271018587970734,1.12889148202879,-5.33733185622788,0.332599347691968,"MAP4K3","mitogen-activated protein kinase kinase kinase kinase 3",TRUE
+"1558732_at",0.617775129514679,0.0888652582584213,1.77958813628,-4.5047309639894,1.26460494636949,"MAP4K4","mitogen-activated protein kinase kinase kinase kinase 4",TRUE
+"206571_s_at",0.649809310340853,0.120287517694738,1.61580493256502,-4.74225530261778,1.5871073860986,"MAP4K4","mitogen-activated protein kinase kinase kinase kinase 4",TRUE
+"222547_at",0.692289844352812,0.161805268470546,1.44733356672466,-4.96785797626683,1.09056941989253,"MAP4K4","mitogen-activated protein kinase kinase kinase kinase 4",TRUE
+"222548_s_at",0.756795789115566,0.252169150605461,1.17576309978041,-5.28789519783572,1.26492420765233,"MAP4K4","mitogen-activated protein kinase kinase kinase kinase 4",TRUE
+"218181_s_at",0.767727587789514,0.270115128256898,1.13108230711267,-5.33506060057183,0.850671295065171,"MAP4K4","mitogen-activated protein kinase kinase kinase kinase 4",TRUE
+"203552_at",0.846506765330126,0.444668664956109,-0.778223903939201,-5.64893042546738,-0.248853682258336,"MAP4K5","mitogen-activated protein kinase kinase kinase kinase 5",TRUE
+"211081_s_at",0.942835367370539,0.743815280683766,-0.330918376491216,-5.88648696771911,-0.143390199780194,"MAP4K5","mitogen-activated protein kinase kinase kinase kinase 5",TRUE
+"203553_s_at",0.991367768700244,0.959611021739377,-0.0512176656537889,-5.93840587351286,-0.0157897170009864,"MAP4K5","mitogen-activated protein kinase kinase kinase kinase 5",TRUE
+"235672_at",0.812896635201594,0.361986179739428,0.930804851237961,-5.52628007324124,0.442874182539596,"MAP6","microtubule associated protein 6",TRUE
+"228943_at",0.899808883319249,0.593306990260438,0.541883529200927,-5.79766655027668,0.245135720676347,"MAP6","microtubule associated protein 6",TRUE
+"241980_at",0.961644868810744,0.826133266477579,-0.222278440728998,-5.9156474203699,-0.113689943172548,"MAP6","microtubule associated protein 6",TRUE
+"228448_at",0.996261754016157,0.981414029083931,-0.0235605679165998,-5.93941311544655,-0.0157457992085641,"MAP6","microtubule associated protein 6",TRUE
+"221713_s_at",0.932625096890813,0.702395819421552,-0.38707194253552,-5.86697170015794,-0.224107126571697,"MAP6D1","MAP6 domain containing 1",TRUE
+"239473_x_at",0.955904644595647,0.800276028720451,0.256047986694132,-5.90780169600438,0.153510870044575,"MAP6D1","MAP6 domain containing 1",TRUE
+"242838_at",0.958933497686198,0.814214876572826,-0.237808608065553,-5.91217610851102,-0.0820430153887193,"MAP6D1","MAP6 domain containing 1",TRUE
+"215471_s_at",0.817915083386752,0.37089584237817,0.913339993836308,-5.54134822027792,0.818281053668358,"MAP7","microtubule associated protein 7",TRUE
+"202889_x_at",0.82979599608837,0.401283893606934,0.855772231903172,-5.58914419151044,1.07581271402821,"MAP7","microtubule associated protein 7",TRUE
+"202890_at",0.852094603401457,0.457713297428979,0.755827848742933,-5.66520202377503,1.01001771455486,"MAP7","microtubule associated protein 7",TRUE
+"217943_s_at",0.749197955891564,0.242310139208882,1.20132393801482,-5.26019497733254,0.45745241053141,"MAP7D1","MAP7 domain containing 1",TRUE
+"228262_at",0.0592928515268338,0.000125397439699677,4.63655264657536,1.17319467684698,4.0831140340847,"MAP7D2","MAP7 domain containing 2",TRUE
+"219626_at",0.534873540719944,0.0425453137373761,2.15205561182488,-3.9052013625008,1.08725600470911,"MAP7D3","MAP7 domain containing 3",TRUE
+"219576_at",0.62179111032845,0.0921968089882532,1.76006746298123,-4.53393629691909,1.71431403316827,"MAP7D3","MAP7 domain containing 3",TRUE
+"237842_at",0.860714927752408,0.480594128270245,0.71744765896483,-5.69203933667465,0.549602693765507,"MAP7D3","MAP7 domain containing 3",TRUE
+"235550_at",0.635368778245437,0.106211839792375,-1.68403750490588,-4.64540189360566,-1.06450570491781,"MAP9","microtubule associated protein 9",TRUE
+"239415_at",0.680997278535937,0.148991119265604,-1.49511856024221,-4.90588193613823,-1.01807868028922,"MAP9","microtubule associated protein 9",TRUE
+"228423_at",0.820291269575398,0.378944820581399,-0.89780008834489,-5.55453413476061,-0.690547384747568,"MAP9","microtubule associated protein 9",TRUE
+"220145_at",0.841420204214686,0.432243246334525,-0.799932458000716,-5.63273100720632,-0.714697044995749,"MAP9","microtubule associated protein 9",TRUE
+"229847_at",0.632949074657601,0.103866983398306,1.69613829778177,-4.6279079216756,0.773823307384514,"MAPK1","mitogen-activated protein kinase 1",TRUE
+"1552263_at",0.837393127867504,0.421396531287366,0.819200708332396,-5.6180019042137,0.504512549396862,"MAPK1","mitogen-activated protein kinase 1",TRUE
+"224621_at",0.931370027472813,0.695508020026623,0.396529053061715,-5.86338879472273,0.150410030733827,"MAPK1","mitogen-activated protein kinase 1",TRUE
+"224620_at",0.948429371744093,0.765703990098233,0.301687128309084,-5.89545033798577,0.122573730270529,"MAPK1","mitogen-activated protein kinase 1",TRUE
+"212271_at",0.966593471043185,0.844155954039074,0.19889855570697,-5.92043330236152,0.0686121497871497,"MAPK1","mitogen-activated protein kinase 1",TRUE
+"1552264_a_at",0.97979222603145,0.903409278130486,0.122753080927142,-5.93234692213598,0.048357201072875,"MAPK1","mitogen-activated protein kinase 1",TRUE
+"208351_s_at",0.984132887597385,0.92204905796156,0.0989738173124597,-5.93491342571428,0.0418616352932553,"MAPK1","mitogen-activated protein kinase 1",TRUE
+"214376_at",0.686108994812404,0.154612029844706,1.47376275682485,-4.93378107610263,0.648114943692883,"MAPK10","mitogen-activated protein kinase 10",TRUE
+"204813_at",0.950214160603623,0.774036220810885,0.290631377851118,-5.89862644812833,0.131876031421379,"MAPK10","mitogen-activated protein kinase 10",TRUE
+"237413_at",0.957174671135192,0.806137876461472,-0.248367137597153,-5.90968297228848,-0.247288103063382,"MAPK10","mitogen-activated protein kinase 10",TRUE
+"211499_s_at",0.845588139978284,0.442972682605618,-0.78116485569794,-5.6467604072475,-0.741449852631619,"MAPK11","mitogen-activated protein kinase 11",TRUE
+"211500_at",0.87927534655779,0.533202555762652,-0.633016482434269,-5.74637471490721,-0.614370424324532,"MAPK11","mitogen-activated protein kinase 11",TRUE
+"206040_s_at",0.9832781796011,0.918400049948255,0.103623914259559,-5.93445479094456,0.0582656314926862,"MAPK11","mitogen-activated protein kinase 11",TRUE
+"1556341_s_at",0.708894565317004,0.181258646190406,1.38031356520993,-5.05200317882681,1.01050749345548,"MAPK12","mitogen-activated protein kinase 12",TRUE
+"1556340_at",0.833099102740246,0.410218455308146,0.839385870912668,-5.60221984490941,0.311946643432836,"MAPK12","mitogen-activated protein kinase 12",TRUE
+"206106_at",0.956619372543067,0.803112355414531,0.252329577361042,-5.90871955952737,0.143727075601754,"MAPK12","mitogen-activated protein kinase 12",TRUE
+"210059_s_at",0.61591966964196,0.0870454739336703,1.7905183311634,-4.48827525643691,1.55570070026848,"MAPK13","mitogen-activated protein kinase 13",TRUE
+"210058_at",0.630522419457597,0.101437846604689,1.70892113823059,-4.60932562764253,1.34608234663161,"MAPK13","mitogen-activated protein kinase 13",TRUE
+"211561_x_at",0.762782461459876,0.26242626576064,1.14994855346221,-5.31534112089299,0.319435807612765,"MAPK14","mitogen-activated protein kinase 14",TRUE
+"210449_x_at",0.803111243433434,0.340912827596645,0.973296323643362,-5.48852715223646,0.274065911281888,"MAPK14","mitogen-activated protein kinase 14",TRUE
+"202530_at",0.894538680437601,0.571066453549971,0.575027332586026,-5.77990360162675,0.164598174361545,"MAPK14","mitogen-activated protein kinase 14",TRUE
+"211087_x_at",0.904832003218088,0.610166822951328,0.5171631400529,-5.81024762655768,0.200730291883835,"MAPK14","mitogen-activated protein kinase 14",TRUE
+"241528_at",0.268558783291603,0.00412897845178268,-3.19772921667643,-1.90352820196116,-1.93698007667711,"MAPK15","mitogen-activated protein kinase 15",TRUE
+"241357_at",0.897949253801113,0.586621348521478,0.551780723408458,-5.79246945276724,0.334377909370021,"MAPK15","mitogen-activated protein kinase 15",TRUE
+"212497_at",0.780872939723948,0.30264404496796,-1.05533570688936,-5.41131257877588,-0.533881393008268,"MAPK1IP1L","mitogen-activated protein kinase 1 interacting protein 1 like",TRUE
+"212644_s_at",0.901788521024914,0.599612291518627,-0.532599296788134,-5.80245864346338,-0.153946231687017,"MAPK1IP1L","mitogen-activated protein kinase 1 interacting protein 1 like",TRUE
+"212643_at",0.925375904025762,0.676600896762493,-0.422682414219611,-5.85303723698817,-0.129200845381643,"MAPK1IP1L","mitogen-activated protein kinase 1 interacting protein 1 like",TRUE
+"225643_at",0.999016635322945,0.996853053134721,0.00398886303524336,-5.93967573107682,0.00126875344401078,"MAPK1IP1L","mitogen-activated protein kinase 1 interacting protein 1 like",TRUE
+"212499_s_at",0.89390639630277,0.569731620855414,-0.577037032949583,-5.77879367053399,-0.166667380837785,"MAPK1IP1L///FCF1","mitogen-activated protein kinase 1 interacting protein 1 like///FCF1 rRNA-processing protein",TRUE
+"212046_x_at",0.622917527985155,0.0938041783609619,-1.7508651387853,-4.54762192179676,-1.12564063332134,"MAPK3","mitogen-activated protein kinase 3",TRUE
+"204708_at",0.703407212050887,0.175121700419509,1.40080818150397,-5.02662047925094,0.636722207880667,"MAPK4","mitogen-activated protein kinase 4",TRUE
+"230732_s_at",0.947778780715578,0.761949441054652,0.306681398339568,-5.89397703922305,0.118514643853925,"MAPK4","mitogen-activated protein kinase 4",TRUE
+"204707_s_at",0.989524702314661,0.94870783957308,-0.065062331331745,-5.93762190073063,-0.0460264133681001,"MAPK4","mitogen-activated protein kinase 4",TRUE
+"207121_s_at",0.661974206478491,0.12927554242202,-1.5756621606399,-4.79778855615928,-0.515682571565465,"MAPK6","mitogen-activated protein kinase 6",TRUE
+"243831_at",0.970573392456845,0.860082125916534,-0.178332786378497,-5.92420547573606,-0.144764508284149,"MAPK6","mitogen-activated protein kinase 6",TRUE
+"207292_s_at",0.562643595171948,0.0551899318602852,2.0240248757461,-4.11990120982111,1.07571214636402,"MAPK7","mitogen-activated protein kinase 7",TRUE
+"35617_at",0.697024771876578,0.166623352495477,1.43015688623243,-4.98973561841825,0.421993326787545,"MAPK7","mitogen-activated protein kinase 7",TRUE
+"210477_x_at",0.748760747870936,0.241818852280669,-1.20261791398006,-5.25877891434353,-0.439548142839768,"MAPK8","mitogen-activated protein kinase 8",TRUE
+"226046_at",0.774360462422895,0.290470635268651,1.08296161074065,-5.38404791631642,0.417058301406639,"MAPK8","mitogen-activated protein kinase 8",TRUE
+"210671_x_at",0.815634970791029,0.366506374498275,0.921908923792692,-5.53398805072286,0.330953017044527,"MAPK8","mitogen-activated protein kinase 8",TRUE
+"226048_at",0.906845308365483,0.614941310548873,0.510222187135353,-5.81367723441508,0.186189061906411,"MAPK8","mitogen-activated protein kinase 8",TRUE
+"229664_at",0.921099538791859,0.664067702242296,-0.440184558515379,-5.8457470644011,-0.164390108911491,"MAPK8","mitogen-activated protein kinase 8",TRUE
+"213014_at",0.740610299769501,0.230100834690123,-1.23408634460393,-5.22393520844657,-0.603482328516491,"MAPK8IP1","mitogen-activated protein kinase 8 interacting protein 1",TRUE
+"208603_s_at",0.699391325858549,0.170937531787639,-1.4151120553122,-5.00872218696578,-1.32791420519908,"MAPK8IP2","mitogen-activated protein kinase 8 interacting protein 2",TRUE
+"205050_s_at",0.937113154905832,0.719536889271512,-0.363689859265482,-5.87546403208613,-0.228065847157835,"MAPK8IP2","mitogen-activated protein kinase 8 interacting protein 2",TRUE
+"216137_s_at",0.697172073261335,0.167204654715762,1.42811162650883,-4.99232640103437,0.830426562340287,"MAPK8IP3","mitogen-activated protein kinase 8 interacting protein 3",TRUE
+"216139_s_at",0.713269796941206,0.187752700824469,1.35921720926235,-5.0778063799157,0.994360402480193,"MAPK8IP3","mitogen-activated protein kinase 8 interacting protein 3",TRUE
+"213178_s_at",0.854184492233394,0.464810624454244,0.743803606404484,-5.67375261472483,0.224281386228862,"MAPK8IP3","mitogen-activated protein kinase 8 interacting protein 3",TRUE
+"232085_at",0.90344422113846,0.604455816508794,0.525499531768131,-5.8060688398876,0.376453406211716,"MAPK8IP3","mitogen-activated protein kinase 8 interacting protein 3",TRUE
+"213177_at",0.91671872326659,0.648094968899913,0.462695057483721,-5.8359442687482,0.341441281176204,"MAPK8IP3","mitogen-activated protein kinase 8 interacting protein 3",TRUE
+"203218_at",0.482262518773694,0.0274932362579488,-2.35995902058078,-3.53947958795777,-0.943426289482623,"MAPK9","mitogen-activated protein kinase 9",TRUE
+"210570_x_at",0.488346123638981,0.0290262892478141,-2.3345399976423,-3.58525269664154,-0.970117666720412,"MAPK9","mitogen-activated protein kinase 9",TRUE
+"225781_at",0.606900628956089,0.0806148883434935,-1.83079333696458,-4.42701099799568,-0.729317101525105,"MAPK9","mitogen-activated protein kinase 9",TRUE
+"229846_s_at",0.649616738237528,0.120180581751671,-1.61629739819747,-4.74156729848676,-0.621515929280008,"MAPKAP1","mitogen-activated protein kinase associated protein 1",TRUE
+"229845_at",0.722337976437859,0.198793224169373,-1.32463520819228,-5.11938419902153,-0.457829079123679,"MAPKAP1","mitogen-activated protein kinase associated protein 1",TRUE
+"217808_s_at",0.761261833217751,0.260283204755774,-1.15527949515852,-5.30971708632709,-0.350792486351818,"MAPKAP1","mitogen-activated protein kinase associated protein 1",TRUE
+"222426_at",0.936992192746977,0.718634863348351,-0.364915060318129,-5.87503200158844,-0.125691792434599,"MAPKAP1","mitogen-activated protein kinase associated protein 1",TRUE
+"201461_s_at",0.615637099066718,0.086140998715996,-1.79602436929772,-4.47995798973858,-0.886815065869941,"MAPKAPK2","mitogen-activated protein kinase-activated protein kinase 2",TRUE
+"201460_at",0.637485146909712,0.108594641299593,-1.67197056918443,-4.6627525641811,-0.824028931739758,"MAPKAPK2","mitogen-activated protein kinase-activated protein kinase 2",TRUE
+"215050_x_at",0.736020435324742,0.221156874562213,-1.25893454074292,-5.1958741677329,-0.678908366012802,"MAPKAPK2","mitogen-activated protein kinase-activated protein kinase 2",TRUE
+"202788_at",0.906222238025079,0.612828168399478,-0.51329103423228,-5.81216645168149,-0.193654456537551,"MAPKAPK3","mitogen-activated protein kinase-activated protein kinase 3",TRUE
+"202787_s_at",0.998870448604467,0.995325704093373,0.00592485011335875,-5.93966638297305,0.00245426949924621,"MAPKAPK3","mitogen-activated protein kinase-activated protein kinase 3",TRUE
+"212871_at",0.501591596209182,0.0321273504409469,-2.28668749977948,-3.67064712880624,-0.709168689086178,"MAPKAPK5","mitogen-activated protein kinase-activated protein kinase 5",TRUE
+"64432_at",0.715119690416591,0.19080607297147,-1.34949674020686,-5.08958397436874,-0.601782875473685,"MAPKAPK5-AS1","MAPKAPK5 antisense RNA 1",TRUE
+"212868_x_at",0.822173415758858,0.386297105739826,-0.883793934623818,-5.56623922682205,-0.544219317972134,"MAPKAPK5-AS1","MAPKAPK5 antisense RNA 1",TRUE
+"219817_at",0.904381089098038,0.607975069955564,0.520358036631777,-5.80865381242887,0.211105894900662,"MAPKAPK5-AS1","MAPKAPK5 antisense RNA 1",TRUE
+"1553987_at",0.955735662836499,0.797947492994842,-0.259103442333502,-5.90703749206622,-0.0730615619891726,"MAPKAPK5-AS1","MAPKAPK5 antisense RNA 1",TRUE
+"213394_at",0.861665593344139,0.483706395005126,0.712310768351323,-5.69553045650107,0.40338282105075,"MAPKBP1","mitogen-activated protein kinase binding protein 1",TRUE
+"1558839_at",0.979588787486838,0.902732473545227,0.123617778997825,-5.93224323579747,0.0600680631914052,"MAPKBP1","mitogen-activated protein kinase binding protein 1",TRUE
+"200712_s_at",0.591331966259927,0.0686656118080173,1.91369363212264,-4.29786528196461,0.556734673131025,"MAPRE1","microtubule associated protein RP/EB family member 1",TRUE
+"200713_s_at",0.623852759019384,0.0954741909500582,1.74144620593783,-4.56157479447599,0.491836944188018,"MAPRE1","microtubule associated protein RP/EB family member 1",TRUE
+"202501_at",0.819780516863333,0.377608601790488,0.900364701401694,-5.55237241588768,0.570552118080789,"MAPRE2","microtubule associated protein RP/EB family member 2",TRUE
+"213489_at",0.864262241343417,0.491534451395639,-0.699474302761708,-5.70414985179972,-0.786526150745059,"MAPRE2","microtubule associated protein RP/EB family member 2",TRUE
+"211556_at",0.932249295738588,0.701002096714384,-0.38898263057961,-5.86625468953367,-0.309579655187498,"MAPRE2","microtubule associated protein RP/EB family member 2",TRUE
+"203841_x_at",0.697172073261335,0.167227125191923,1.42803268085565,-4.99242634264658,1.4669105353323,"MAPRE3","microtubule associated protein RP/EB family member 3",TRUE
+"229682_at",0.82364723261727,0.390713266477465,0.875464657772811,-5.57311917803484,0.41065091551934,"MAPRE3","microtubule associated protein RP/EB family member 3",TRUE
+"203842_s_at",0.848459161522831,0.448678550290071,0.771297553335394,-5.65401060989598,0.61765607268637,"MAPRE3","microtubule associated protein RP/EB family member 3",TRUE
+"214270_s_at",0.864894115958506,0.49379038569077,0.695796877629014,-5.7065916152632,0.380206445847935,"MAPRE3","microtubule associated protein RP/EB family member 3",TRUE
+"206401_s_at",0.595936234743389,0.0723427861360075,-1.8869219507366,-4.34001130532659,-2.76300019883565,"MAPT","microtubule associated protein tau",TRUE
+"225379_at",0.597654932724127,0.0743530246420891,-1.87278617608606,-4.36209692507318,-2.46337570458692,"MAPT","microtubule associated protein tau",TRUE
+"203930_s_at",0.620129049200068,0.0898627738240066,-1.77367828079371,-4.51359774974528,-1.33266463953143,"MAPT","microtubule associated protein tau",TRUE
+"203929_s_at",0.678316331743091,0.145650365517401,-1.50812440702282,-4.88873324973126,-1.41402309403887,"MAPT","microtubule associated protein tau",TRUE
+"203928_x_at",0.725168361556674,0.203469183829993,-1.3104408696584,-5.13618882555024,-1.54738046506094,"MAPT","microtubule associated protein tau",TRUE
+"233117_at",0.820536502908875,0.380735350203336,-0.894372820495574,-5.55741408291615,-0.63817968208778,"MAPT","microtubule associated protein tau",TRUE
+"237536_at",0.675622576285316,0.141933465311081,1.52288468416583,-4.86912750402671,0.788395506260355,"MAPT-AS1","MAPT antisense RNA 1",TRUE
+"237331_s_at",0.785553614313586,0.311074920960283,1.03666327816147,-5.42938258656191,0.261026892206913,"MAPT-AS1","MAPT antisense RNA 1",TRUE
+"236790_s_at",0.84231658612216,0.435973236212025,0.793375894614651,-5.63766787782108,0.38932166675027,"MAPT-AS1","MAPT antisense RNA 1",TRUE
+"1563367_at",0.854350135157525,0.465241767708958,-0.743076704344321,-5.67426535941994,-0.783054819836508,"MAPT-AS1","MAPT antisense RNA 1",TRUE
+"236789_at",0.948567563026335,0.765983432924022,-0.301315730339518,-5.89555894177374,-0.226908442456927,"MAPT-AS1","MAPT antisense RNA 1",TRUE
+"218865_at",0.880203017022901,0.535656058260686,0.629194099365018,-5.74868031264586,0.696899525249526,"MARC1","mitochondrial amidoxime reducing component 1",TRUE
+"227417_at",0.957813759927439,0.810357141707457,-0.242848047822147,-5.91099960073473,-0.193584370909694,"MARC2","mitochondrial amidoxime reducing component 2",TRUE
+"221636_s_at",0.985498770484702,0.929508476701051,-0.0894747782400238,-5.93578493406726,-0.0622301553669811,"MARC2","mitochondrial amidoxime reducing component 2",TRUE
+"219527_at",0.991689960875868,0.961166918529433,0.049242916465601,-5.9385024875117,0.04107809224306,"MARC2","mitochondrial amidoxime reducing component 2",TRUE
+"235385_at",0.336678756703507,0.00833768699728485,2.89630531726941,-2.51627218434902,2.8652846066415,"MARCH1","membrane associated ring-CH-type finger 1",TRUE
+"229383_at",0.522667179791589,0.0384143611376843,2.20141437733404,-3.82021512560555,1.00939307551194,"MARCH1","membrane associated ring-CH-type finger 1",TRUE
+"219574_at",0.727074488271062,0.207227480088322,1.29921507768103,-5.14937052911334,1.36368545544613,"MARCH1","membrane associated ring-CH-type finger 1",TRUE
+"1562338_at",0.820536502908875,0.380383419512653,-0.895045616600017,-5.55684953335259,-0.724579162866324,"MARCH1","membrane associated ring-CH-type finger 1",TRUE
+"230824_at",0.815775199549376,0.366701410601486,0.921526737146082,-5.5343176740538,0.393093549654265,"MARCH10","membrane associated ring-CH-type finger 10",TRUE
+"237724_at",0.946727564264032,0.758496919899167,-0.311280947052763,-5.8925989796363,-0.203945939134281,"MARCH10","membrane associated ring-CH-type finger 10",TRUE
+"239359_at",0.84571977676742,0.443331021016592,-0.780542899851118,-5.64721996862137,-0.550422196427638,"MARCH11","membrane associated ring-CH-type finger 11",TRUE
+"210075_at",0.988224361618126,0.943839202160811,-0.0712484858004139,-5.93721128185323,-0.0303163224136647,"MARCH2","membrane associated ring-CH-type finger 2",TRUE
+"213256_at",0.326089462713281,0.00749262826361455,-2.94268169719054,-2.42344866188702,-1.41973186376712,"MARCH3","membrane associated ring-CH-type finger 3",TRUE
+"230385_at",0.867972140419125,0.501572403317405,-0.683184374507066,-5.71487278756425,-0.376394792360363,"MARCH3","membrane associated ring-CH-type finger 3",TRUE
+"230112_at",0.700511129947842,0.172323515280614,1.41034328462202,-5.01470593875735,1.3166520524193,"MARCH4","membrane associated ring-CH-type finger 4",TRUE
+"226394_at",0.79141923683682,0.321937910315276,-1.0131227924137,-5.45174889209879,-0.39437487759834,"MARCH5","membrane associated ring-CH-type finger 5",TRUE
+"218582_at",0.801587742916188,0.338946630607761,-0.97735108397374,-5.48484410020762,-0.363922478649675,"MARCH5","membrane associated ring-CH-type finger 5",TRUE
+"201736_s_at",0.67565343307767,0.142234329906483,1.52167820099828,-4.87073576322542,0.470148825658217,"MARCH6","membrane associated ring-CH-type finger 6",TRUE
+"201737_s_at",0.750326501261927,0.24328484685637,1.19876253031115,-5.26299414770137,0.713839135484982,"MARCH6","membrane associated ring-CH-type finger 6",TRUE
+"215512_at",0.806649582904638,0.347606420135571,0.959611220427307,-5.50085447944792,0.547179488736731,"MARCH6","membrane associated ring-CH-type finger 6",TRUE
+"212498_at",0.812302873476553,0.358647576797685,0.937423220450446,-5.52050136838068,0.394568407129386,"MARCH6","membrane associated ring-CH-type finger 6",TRUE
+"215422_at",0.87825462101175,0.530617727007674,0.637053760487863,-5.74392491004936,0.41261023444308,"MARCH6","membrane associated ring-CH-type finger 6",TRUE
+"215423_at",0.952239474918707,0.781384984768684,-0.28091120273781,-5.90132170979911,-0.143382690545859,"MARCH6","membrane associated ring-CH-type finger 6",TRUE
+"1557704_a_at",0.717613212957928,0.193372669708316,1.34142015683348,-5.09931595537054,0.879911938937871,"MARCH7","membrane associated ring-CH-type finger 7",TRUE
+"202654_x_at",0.739189560382301,0.225981117089425,-1.24543851127516,-5.21117487417836,-0.34258474892947,"MARCH7","membrane associated ring-CH-type finger 7",TRUE
+"202653_s_at",0.776978557113863,0.295855813087399,-1.07064050716719,-5.39628578239003,-0.345496366676658,"MARCH7","membrane associated ring-CH-type finger 7",TRUE
+"232371_at",0.968917934155285,0.853197145677297,0.187213305297614,-5.92262689588939,0.0916795721646473,"MARCH7","membrane associated ring-CH-type finger 7",TRUE
+"1557703_at",0.971511156698413,0.864362102271359,-0.172819739388794,-5.92514699176824,-0.156816101344848,"MARCH7","membrane associated ring-CH-type finger 7",TRUE
+"221824_s_at",0.896118799730606,0.578472954696583,-0.563919258876902,-5.78597074955299,-0.286382693107081,"MARCH8","membrane associated ring-CH-type finger 8",TRUE
+"231933_at",0.910159094731364,0.625825259633873,-0.494493303899622,-5.82128173057229,-0.15579788562715,"MARCH8","membrane associated ring-CH-type finger 8",TRUE
+"236056_s_at",0.959623505183049,0.817755433991562,-0.233189041233795,-5.91323303695755,-0.152504651900907,"MARCH8","membrane associated ring-CH-type finger 8",TRUE
+"226454_at",0.56861088242915,0.0585333008624047,-1.99459314122892,-4.16803328563424,-0.956409447960626,"MARCH9","membrane associated ring-CH-type finger 9",TRUE
+"230001_at",0.711902920992134,0.185570012436761,-1.36624252673395,-5.06925038739193,-0.38279800475556,"MARCH9","membrane associated ring-CH-type finger 9",TRUE
+"225897_at",0.586805866674409,0.0662202505236599,1.93220262084322,-4.2684861995602,1.8405079132104,"MARCKS","myristoylated alanine rich protein kinase C substrate",TRUE
+"213002_at",0.605664606439963,0.0792020922598773,1.84001327260006,-4.41284836355611,1.40261895112363,"MARCKS","myristoylated alanine rich protein kinase C substrate",TRUE
+"201668_x_at",0.609886795316146,0.081987525296272,1.82196880028883,-4.44051846756635,2.12461181608094,"MARCKS","myristoylated alanine rich protein kinase C substrate",TRUE
+"201669_s_at",0.7083523771159,0.180260140131809,1.38361016822225,-5.0479412336197,1.41725158554975,"MARCKS","myristoylated alanine rich protein kinase C substrate",TRUE
+"201670_s_at",0.712148529314333,0.186274752768119,1.36396711253088,-5.07202559576361,1.80795341120435,"MARCKS","myristoylated alanine rich protein kinase C substrate",TRUE
+"200644_at",0.627092759817312,0.0980029252857482,-1.72744887070204,-4.58220680557445,-0.927274995627567,"MARCKSL1","MARCKS like 1",TRUE
+"205819_at",0.859947009633611,0.478341174817517,0.721178322016327,-5.68948895316315,0.394620600150799,"MARCO","macrophage receptor with collagenous structure",TRUE
+"231613_at",0.620223198657182,0.0900919983259472,1.77232820193074,-4.51562029613007,1.21623343178983,"MARK1","microtubule affinity regulating kinase 1",TRUE
+"226653_at",0.770807031642694,0.279227736720574,1.1092254023035,-5.35754538177439,1.05015852844211,"MARK1","microtubule affinity regulating kinase 1",TRUE
+"221047_s_at",0.781368538085109,0.303055660706169,1.05441556984319,-5.412209818603,0.813240947460611,"MARK1","microtubule affinity regulating kinase 1",TRUE
+"1560407_at",0.828535730541669,0.39865676860002,0.860634862749135,-5.58521868730002,0.443813136540025,"MARK1","microtubule affinity regulating kinase 1",TRUE
+"203942_s_at",0.750533424247413,0.24349267268954,-1.19821738792129,-5.26358922258897,-0.513493391905158,"MARK2","microtubule affinity regulating kinase 2",TRUE
+"211082_x_at",0.977128286470696,0.890817085931835,0.138857543774345,-5.93029657453221,0.0462791285930138,"MARK2","microtubule affinity regulating kinase 2",TRUE
+"202569_s_at",0.59864296780305,0.0755927032411936,-1.86423439081202,-4.37540128569811,-0.572093261116242,"MARK3","microtubule affinity regulating kinase 3",TRUE
+"202568_s_at",0.692337104609683,0.161906213434648,-1.4469694940024,-4.96832389912684,-0.4691737417859,"MARK3","microtubule affinity regulating kinase 3",TRUE
+"232537_x_at",0.868220463162593,0.502202539311299,-0.682167975946119,-5.71553383655273,-0.359871664484928,"MARK3","microtubule affinity regulating kinase 3",TRUE
+"221560_at",0.695744345349551,0.165505273780844,-1.43410691792057,-4.98472342552553,-1.06761783874846,"MARK4","microtubule affinity regulating kinase 4",TRUE
+"55065_at",0.729083413548563,0.210702271083202,-1.28897571311094,-5.16131001565773,-0.68730555866718,"MARK4","microtubule affinity regulating kinase 4",TRUE
+"243529_at",0.803142603559684,0.341146480568269,-0.972815541969369,-5.4889629335354,-0.340260108976798,"MARS2","methionyl-tRNA synthetase 2, mitochondrial",TRUE
+"223095_at",0.406049718268978,0.0152988096869519,2.62825742290096,-3.04028859099822,2.19798776978724,"MARVELD1","MARVEL domain containing 1",TRUE
+"234917_at",0.94333312187812,0.745744089123947,-0.328331081887644,-5.8873134084898,-0.198942088246924,"MARVELD1","MARVEL domain containing 1",TRUE
+"235141_at",0.91960407224049,0.658397096408162,-0.448149157922727,-5.84233346516568,-0.303561202435183,"MARVELD2","MARVEL domain containing 2",TRUE
+"235955_at",0.983929732859461,0.921213772749443,-0.100038058173994,-5.93481031662456,-0.0564702305774176,"MARVELD2","MARVEL domain containing 2",TRUE
+"233634_at",0.835087155533826,0.414004202419558,0.832511166437692,-5.60763527840788,0.805135952731956,"MARVELD3","MARVEL domain containing 3",TRUE
+"239350_at",0.872750243492146,0.517025704375137,0.658462039461103,-5.73068449596317,0.817585827100091,"MARVELD3","MARVEL domain containing 3",TRUE
+"239148_at",0.884221189678062,0.5431035805115,0.617648639542433,-5.7555626871529,0.763979886070651,"MARVELD3","MARVEL domain containing 3",TRUE
+"208210_at",0.71760387697019,0.193342893674401,1.34151337212683,-5.0992039137838,0.657411874941329,"MAS1","MAS1 proto-oncogene, G protein-coupled receptor",TRUE
+"234820_at",0.876278327062923,0.524949617276982,0.645944432866622,-5.73847730473127,0.270838170315064,"MAS1L","MAS1 proto-oncogene like, G protein-coupled receptor",TRUE
+"213749_at",0.808233282592165,0.350069270716828,-0.954621066322398,-5.50530982033811,-0.323358718722537,"MASP1","mannan binding lectin serine peptidase 1",TRUE
+"232224_at",0.837368340567858,0.421237803491273,0.81948496073595,-5.61778215423535,0.376269690838775,"MASP1","mannan binding lectin serine peptidase 1",TRUE
+"206449_s_at",0.869082033398093,0.50594338841243,0.676148823757784,-5.71942930264493,0.278731515018327,"MASP1","mannan binding lectin serine peptidase 1",TRUE
+"210680_s_at",0.946245139372915,0.756217308914486,0.31432166502111,-5.89167679900003,0.104179565126318,"MASP1","mannan binding lectin serine peptidase 1",TRUE
+"235770_at",0.975398143273847,0.880808131845647,0.151684907377758,-5.92848319028102,0.0637716258699963,"MASP1","mannan binding lectin serine peptidase 1",TRUE
+"210798_x_at",0.841346844002252,0.431727722202681,0.800841392207713,-5.63204359572448,0.383484486976726,"MASP2","mannan binding lectin serine peptidase 2",TRUE
+"216968_at",0.954577684533304,0.792228222807261,0.266618925126303,-5.90511946796927,0.156467845195587,"MASP2","mannan binding lectin serine peptidase 2",TRUE
+"207041_at",0.980832655742,0.909965136491724,-0.114382051747823,-5.93331311863254,-0.0337621682029967,"MASP2","mannan binding lectin serine peptidase 2",TRUE
+"217231_s_at",0.90344422113846,0.604221166809421,0.525842854990037,-5.80589534689148,0.201189894212054,"MAST1","microtubule associated serine/threonine kinase 1",TRUE
+"215660_s_at",0.792243446641505,0.323102414526624,1.01063243732735,-5.45408785696679,0.456565291274471,"MAST2","microtubule associated serine/threonine kinase 2",TRUE
+"215903_s_at",0.910276798053706,0.627146167460175,-0.492593055225222,-5.82218471057375,-0.14035162530293,"MAST2","microtubule associated serine/threonine kinase 2",TRUE
+"215661_at",0.916919564257648,0.64861954880491,0.461951959342124,-5.8362755168302,0.333130239241383,"MAST2","microtubule associated serine/threonine kinase 2",TRUE
+"211593_s_at",0.93032716386748,0.692019287052722,-0.401333189471305,-5.86153608133898,-0.125158020672917,"MAST2","microtubule associated serine/threonine kinase 2",TRUE
+"213045_at",0.383328885347805,0.0121971018882167,-2.72931723696808,-2.84539074573482,-1.67778942042368,"MAST3","microtubule associated serine/threonine kinase 3",TRUE
+"225613_at",0.597654932724127,0.0738253757083172,1.87646391146721,-4.35636211161146,1.25136006782692,"MAST4","microtubule associated serine/threonine kinase family member 4",TRUE
+"225611_at",0.599731655615302,0.0761300899307837,1.86056524144419,-4.38109632203885,1.31842672386756,"MAST4","microtubule associated serine/threonine kinase family member 4",TRUE
+"222348_at",0.637485146909712,0.108639733069585,1.67174438450452,-4.66307688489927,1.83733886561989,"MAST4","microtubule associated serine/threonine kinase family member 4",TRUE
+"40016_g_at",0.660460734341314,0.128443569064278,1.57927863456999,-4.79283023025195,1.30201558194617,"MAST4","microtubule associated serine/threonine kinase family member 4",TRUE
+"210958_s_at",0.782977684471234,0.305486602014456,1.04899939722766,-5.41747696667654,0.600661521325403,"MAST4","microtubule associated serine/threonine kinase family member 4",TRUE
+"1554652_s_at",0.904345087496977,0.606998738380687,-0.521782991030349,-5.80793987246747,-0.520301600279014,"MAST4","microtubule associated serine/threonine kinase family member 4",TRUE
+"243575_at",0.91671872326659,0.647874545302115,-0.463007379318119,-5.8358048905479,-0.291602996908289,"MAST4","microtubule associated serine/threonine kinase family member 4",TRUE
+"228468_at",0.846615322073696,0.445086617607432,-0.777500196285071,-5.64946323883087,-0.340711359778069,"MASTL","microtubule associated serine/threonine kinase like",TRUE
+"205813_s_at",0.848701670618582,0.449161234214527,-0.770466344454791,-5.65461738546854,-0.354711643548009,"MAT1A","methionine adenosyltransferase 1A",TRUE
+"200769_s_at",0.816800680706682,0.368976932444582,0.917077665258847,-5.53814558601082,0.42983635339194,"MAT2A","methionine adenosyltransferase 2A",TRUE
+"200768_s_at",0.841813886364358,0.434053234825109,0.796746520366638,-5.63513468303394,0.212944494577973,"MAT2A","methionine adenosyltransferase 2A",TRUE
+"217993_s_at",0.523369751179323,0.0388729981423803,2.19570310982383,-3.83010960341542,0.705810453068802,"MAT2B","methionine adenosyltransferase 2B",TRUE
+"229284_at",0.836756831475262,0.418615446887624,0.824190884943409,-5.61413371854919,0.545421797958253,"MAT2B","methionine adenosyltransferase 2B",TRUE
+"206267_s_at",0.88020017258149,0.535467128516139,0.629488102609229,-5.74850345185004,0.647887730654956,"MATK","megakaryocyte-associated tyrosine kinase",TRUE
+"206904_at",0.93278552880756,0.703133475706901,-0.386061265573041,-5.86734956264973,-0.267531749398065,"MATN1","matrilin 1, cartilage matrix protein",TRUE
+"206905_s_at",0.958640117088134,0.812586670808406,-0.239934791832035,-5.91168272144332,-0.159709814512942,"MATN1","matrilin 1, cartilage matrix protein",TRUE
+"1557558_s_at",0.876632890672003,0.52556189587257,0.644981532937111,-5.73907080773972,0.317749278653245,"MATN1-AS1","MATN1 antisense RNA 1",TRUE
+"1557557_at",0.932091525948902,0.700219816380062,0.390055723334679,-5.86585047164421,0.22250567634053,"MATN1-AS1","MATN1 antisense RNA 1",TRUE
+"206091_at",0.940323871449272,0.733313822743826,0.345046011311098,-5.88186111176384,0.547182897980385,"MATN3","matrilin 3",TRUE
+"207123_s_at",0.769258076576208,0.275940674475615,1.11704869484885,-5.34954199071075,0.559410995511731,"MATN4","matrilin 4",TRUE
+"242260_at",0.70573152022539,0.178045373635651,1.39097438172655,-5.03883833581629,1.13284350152734,"MATR3","matrin 3",TRUE
+"227465_at",0.765278605568716,0.265496192022642,-1.1423676911772,-5.32329936698689,-0.395050015928115,"MAU2","MAU2 sister chromatid cohesion factor",TRUE
+"212505_s_at",0.833285547058304,0.4106912782182,-0.838525058210156,-5.60290021479239,-0.260259608577917,"MAU2","MAU2 sister chromatid cohesion factor",TRUE
+"217652_at",0.942502815705589,0.74211134063949,0.33320595125127,-5.88575091798819,0.254356531509317,"MAU2","MAU2 sister chromatid cohesion factor",TRUE
+"216926_s_at",0.944260235111746,0.750365225333976,-0.322141561210719,-5.88926442903995,-0.313664478391583,"MAU2","MAU2 sister chromatid cohesion factor",TRUE
+"216927_at",0.947926063538122,0.763029481675892,0.305243927080708,-5.89440354719954,0.213237722854334,"MAU2","MAU2 sister chromatid cohesion factor",TRUE
+"226495_at",0.831875452294783,0.40769519822143,0.843990364065337,-5.59856947317586,0.352699200895096,"MAVS","mitochondrial antiviral signaling protein",TRUE
+"229741_at",0.854765853652919,0.46664665689412,0.740710851122491,-5.67593090201278,0.300011192348112,"MAVS","mitochondrial antiviral signaling protein",TRUE
+"231829_at",0.961212424803935,0.823136664329091,0.226177730142626,-5.91479777182431,0.113738752158923,"MAVS","mitochondrial antiviral signaling protein",TRUE
+"220305_at",0.96351240321323,0.83368571382729,0.212466385784847,-5.91772038101427,0.0883628745765463,"MAVS","mitochondrial antiviral signaling protein",TRUE
+"209332_s_at",0.468735421183467,0.0250277265884973,-2.40371841855678,-3.46002887676875,-0.727290084344794,"MAX","MYC associated factor X",TRUE
+"214108_at",0.755158214384019,0.24913154838126,-1.18355759161248,-5.27950337655727,-0.646105351560236,"MAX","MYC associated factor X",TRUE
+"209331_s_at",0.77938352158119,0.30058096441987,-1.05996103195431,-5.40679171781193,-0.317827600266284,"MAX","MYC associated factor X",TRUE
+"210734_x_at",0.784552021081681,0.308033567102618,-1.04335739700659,-5.42293779971873,-0.437381072110123,"MAX","MYC associated factor X",TRUE
+"208403_x_at",0.88379975017027,0.542063813877948,-0.619255422887602,-5.7546122213764,-0.214391654406118,"MAX","MYC associated factor X",TRUE
+"207824_s_at",0.380731642340006,0.01192984430677,-2.73913093135649,-2.82628459834867,-1.13961396873187,"MAZ","MYC associated zinc finger protein",TRUE
+"212064_x_at",0.680997278535937,0.148981684747669,-1.49515495285148,-4.90583411739728,-0.614260038003993,"MAZ","MYC associated zinc finger protein",TRUE
+"204179_at",0.769847953580141,0.278364307251821,-1.11127386875447,-5.35545457792165,-1.27934944903634,"MB","myoglobin",TRUE
+"242077_x_at",0.29806620002593,0.00547340584958452,3.07777949390333,-2.14991132709716,1.67939405176886,"MB21D1","Mab-21 domain containing 1",TRUE
+"1559051_s_at",0.360736459722853,0.0103095483129252,2.80350666677752,-2.70020173977558,3.57140756705533,"MB21D1","Mab-21 domain containing 1",TRUE
+"1561708_at",0.652199141379004,0.121338265498075,1.61098536145117,-4.74897997009346,1.19706660221574,"MB21D1","Mab-21 domain containing 1",TRUE
+"227599_at",0.635916735157933,0.107121958369068,1.67940171304814,-4.65207873024205,0.987135692334,"MB21D2","Mab-21 domain containing 2",TRUE
+"208595_s_at",0.587626678796111,0.0667070612440364,-1.92847056896517,-4.27442576180879,-0.911818434213801,"MBD1","methyl-CpG binding domain protein 1",TRUE
+"203353_s_at",0.643082025527735,0.113412573711454,-1.64823978145964,-4.6965973340466,-0.512765117344578,"MBD1","methyl-CpG binding domain protein 1",TRUE
+"226862_at",0.712948021516228,0.1870422777727,-1.36149670485654,-5.07503426052961,-0.390268705337466,"MBD1","methyl-CpG binding domain protein 1",TRUE
+"241813_at",0.768852835478002,0.274171444596518,-1.12128765149554,-5.34518463866424,-1.24094305916886,"MBD1","methyl-CpG binding domain protein 1",TRUE
+"1555611_s_at",0.868714861166452,0.504939974960309,-0.677760880623585,-5.71838925169595,-0.23044891097914,"MBD1","methyl-CpG binding domain protein 1",TRUE
+"214396_s_at",0.18860161541457,0.00186687416358304,-3.53033422020513,-1.20661246639239,-1.65235884472353,"MBD2","methyl-CpG binding domain protein 2",TRUE
+"202484_s_at",0.695005304830231,0.164545807679973,-1.43751373467227,-4.98039144135567,-0.423776711369882,"MBD2","methyl-CpG binding domain protein 2",TRUE
+"214397_at",0.724970327905974,0.202627837803991,-1.31297596931816,-5.13319874599276,-0.782791507042218,"MBD2","methyl-CpG binding domain protein 2",TRUE
+"202485_s_at",0.890326168210711,0.558703078761948,0.593734639360845,-5.76942692318818,0.171406820494787,"MBD2","methyl-CpG binding domain protein 2",TRUE
+"41160_at",0.822241803732333,0.387004091200516,-0.882456341981073,-5.56734814611397,-0.316894531876063,"MBD3","methyl-CpG binding domain protein 3",TRUE
+"202463_s_at",0.87825462101175,0.530393604274143,0.637404322404694,-5.74371148370797,0.356474592735134,"MBD3","methyl-CpG binding domain protein 3",TRUE
+"222183_x_at",0.95018792835023,0.773555702915121,-0.291267943190517,-5.89844676500563,-0.163843109156841,"MBD3","methyl-CpG binding domain protein 3",TRUE
+"1552459_a_at",0.48580305784244,0.0283668995871844,2.34531793733897,-3.56587883170306,1.31676783731281,"MBD3L1","methyl-CpG binding domain protein 3 like 1",TRUE
+"1552458_at",0.825376550784618,0.392810899425404,0.871529756994916,-5.57634835524978,0.758460352920833,"MBD3L1","methyl-CpG binding domain protein 3 like 1",TRUE
+"1552456_a_at",0.866047073324492,0.496635799701846,0.691172211337408,-5.70964489586057,0.398591578069688,"MBD3L2","methyl-CpG binding domain protein 3 like 2",TRUE
+"214048_at",0.627092759817312,0.098929965576664,-1.72239461145426,-4.58962631451127,-0.711230504772865,"MBD4","methyl-CpG binding domain 4, DNA glycosylase",TRUE
+"214047_s_at",0.867534497779617,0.500131456241674,-0.685511317464598,-5.7133558399941,-0.261547789775435,"MBD4","methyl-CpG binding domain 4, DNA glycosylase",TRUE
+"209580_s_at",0.873301865850313,0.518390709760803,-0.656298205745648,-5.73204184520561,-0.235107623522939,"MBD4","methyl-CpG binding domain 4, DNA glycosylase",TRUE
+"209579_s_at",0.8920930097751,0.563432784567596,-0.586553100682822,-5.77348718033062,-0.20253851565969,"MBD4","methyl-CpG binding domain 4, DNA glycosylase",TRUE
+"244662_at",0.620912785033482,0.0909624332947022,-1.76722829482639,-4.5232502530615,-1.1531451058271,"MBD5","methyl-CpG binding domain protein 5",TRUE
+"220195_at",0.805746717966166,0.345632312361938,-0.963628478047576,-5.49725233284427,-0.41582849142695,"MBD5","methyl-CpG binding domain protein 5",TRUE
+"227839_at",0.970486938098916,0.859211535905188,-0.179454882293864,-5.92401023468044,-0.180099550147879,"MBD5","methyl-CpG binding domain protein 5",TRUE
+"226076_s_at",0.584247456664678,0.0647988696438478,-1.94323932655064,-4.2508750613793,-0.870511841129149,"MBD6","methyl-CpG binding domain protein 6",TRUE
+"227833_s_at",0.640138998523675,0.110863761811078,-1.66068564951074,-4.67889304614474,-0.748960840407168,"MBD6","methyl-CpG binding domain protein 6",TRUE
+"227832_at",0.988706054965124,0.945328622320156,-0.069355717980798,-5.93734087362868,-0.0403315179699781,"MBD6","methyl-CpG binding domain protein 6",TRUE
+"218411_s_at",0.610033432202476,0.0826199941450078,-1.81794575170218,-4.44666085911627,-0.657319185932923,"MBIP","MAP3K12 binding inhibitory protein 1",TRUE
+"207256_at",0.849935057946582,0.451838660482157,0.765865463297435,-5.65796481418065,0.730759699904512,"MBL2","mannose binding lectin 2",TRUE
+"1554170_a_at",0.699418568645285,0.170994568030755,-1.41491520082128,-5.00896952445839,-0.498738831271079,"MBLAC1","metallo-beta-lactamase domain containing 1",TRUE
+"230298_at",0.170374697680568,0.00142911130280268,-3.64099428630657,-0.971308012914004,-1.45434943674578,"MBLAC2","metallo-beta-lactamase domain containing 2",TRUE
+"1554619_at",0.694819513561858,0.164387496627296,-1.4380773917171,-4.97967390600344,-0.799241097944573,"MBLAC2","metallo-beta-lactamase domain containing 2",TRUE
+"1558111_at",0.47984873377716,0.0269961537283684,2.36848170717135,-3.52406966265462,1.1771125670326,"MBNL1","muscleblind like splicing regulator 1",TRUE
+"201152_s_at",0.693850056112024,0.163088185465074,1.44272010106495,-4.9737550040697,0.584006945412625,"MBNL1","muscleblind like splicing regulator 1",TRUE
+"201151_s_at",0.701088870826122,0.172804236214569,1.40869642491915,-5.01676852144592,0.5609291870479,"MBNL1","muscleblind like splicing regulator 1",TRUE
+"201153_s_at",0.736020435324742,0.221092789567479,1.25911533048418,-5.1956682430677,0.416640271768449,"MBNL1","muscleblind like splicing regulator 1",TRUE
+"1555594_a_at",0.818424525797378,0.371677749895727,0.911820667126099,-5.54264661125244,0.40933200013848,"MBNL1","muscleblind like splicing regulator 1",TRUE
+"233015_at",0.839519981963042,0.428058257977787,0.807330653494546,-5.62711457116298,0.361917012799716,"MBNL1","muscleblind like splicing regulator 1",TRUE
+"215663_at",0.910165867297668,0.626319169367196,0.49378255314385,-5.82161987007146,0.500590236171533,"MBNL1","muscleblind like splicing regulator 1",TRUE
+"232298_at",0.693742297578797,0.162894466625293,1.44341484894149,-4.97286794448897,1.24761080696815,"MBNL1-AS1","MBNL1 antisense RNA 1",TRUE
+"235173_at",0.837368340567858,0.420792618521827,-0.820282564084837,-5.6171651612314,-0.440686323217813,"MBNL1-AS1","MBNL1 antisense RNA 1",TRUE
+"205017_s_at",0.51531387545335,0.0359636308133467,2.23302507806564,-3.76516859202406,1.10478885678354,"MBNL2","muscleblind like splicing regulator 2",TRUE
+"232138_at",0.606900628956089,0.0807422767432923,1.82996890762402,-4.42827491205885,1.12949543010283,"MBNL2","muscleblind like splicing regulator 2",TRUE
+"1553536_at",0.62986301194198,0.10080434482701,1.71229758207956,-4.60439985801621,0.543638395650164,"MBNL2","muscleblind like splicing regulator 2",TRUE
+"203640_at",0.723649742218726,0.200330345989475,1.3199406630075,-5.12495896223036,0.89769140922882,"MBNL2","muscleblind like splicing regulator 2",TRUE
+"205018_s_at",0.732963666545614,0.217202608766112,1.27016594488408,-5.18303324084178,0.835378324306252,"MBNL2","muscleblind like splicing regulator 2",TRUE
+"230113_at",0.919181437857039,0.655926529116237,0.451628371050307,-5.84082344514848,0.189815558973879,"MBNL3","muscleblind like splicing regulator 3",TRUE
+"219814_at",0.972624640038332,0.86757479774085,-0.168685067912958,-5.92583376451739,-0.117118100566525,"MBNL3","muscleblind like splicing regulator 3",TRUE
+"229498_at",0.980174445251813,0.9068207122193,-0.11839601448918,-5.93285832216334,-0.0874275260386312,"MBNL3","muscleblind like splicing regulator 3",TRUE
+"227379_at",0.814057826222815,0.365004620207633,0.924856266984562,-5.53144183768445,0.5650093282031,"MBOAT1","membrane bound O-acyltransferase domain containing 1",TRUE
+"226726_at",0.516608685845068,0.0364153612299386,2.227054045405,-3.77560290553074,0.796617044189468,"MBOAT2","membrane bound O-acyltransferase domain containing 2",TRUE
+"213288_at",0.597654932724127,0.0737015487417966,1.87733031557838,-4.35500994560195,0.729365450329119,"MBOAT2","membrane bound O-acyltransferase domain containing 2",TRUE
+"211037_s_at",0.773234064853267,0.284387919033559,1.09707788565131,-5.36987354879395,0.437931494934846,"MBOAT7","membrane bound O-acyltransferase domain containing 7",TRUE
+"209179_s_at",0.975398143273847,0.881363128946559,0.150972966787463,-5.92858802420729,0.0563613138334329,"MBOAT7","membrane bound O-acyltransferase domain containing 7",TRUE
+"1554544_a_at",0.615821255316333,0.086646667341385,1.79293997306815,-4.48461947928403,1.89800480498941,"MBP","myelin basic protein",TRUE
+"225408_at",0.615821255316333,0.0867370152433884,1.79239051957394,-4.48544926456308,1.06271782203226,"MBP","myelin basic protein",TRUE
+"210136_at",0.643688366500038,0.114308487961983,1.64392094870818,-4.70271708454243,1.90883144943057,"MBP","myelin basic protein",TRUE
+"225407_at",0.704449222279154,0.176432972928887,1.39638165898972,-5.03212894841415,1.69831377769602,"MBP","myelin basic protein",TRUE
+"216567_at",0.774230543658252,0.289922356521293,1.08422522731335,-5.38278576834004,0.367066398532071,"MBP","myelin basic protein",TRUE
+"236324_at",0.78638420006208,0.311823896201859,1.0350218509893,-5.43095717208398,0.697871937007395,"MBP","myelin basic protein",TRUE
+"209072_at",0.792344934473527,0.323485788632162,-1.0098139400348,-5.45485545908396,-0.591583104207257,"MBP","myelin basic protein",TRUE
+"228938_at",0.936992192746977,0.718344778169179,-0.365309197215546,-5.87489271605619,-0.235085999666263,"MBP","myelin basic protein",TRUE
+"207323_s_at",0.97928472590149,0.899956842023709,-0.127164994618425,-5.93181028208704,-0.0668472635490192,"MBP","myelin basic protein",TRUE
+"226797_at",0.677013732819214,0.144294930691004,-1.51347087159412,-4.88164927044334,-0.628564582799154,"MBTD1","mbt domain containing 1",TRUE
+"243552_at",0.767965891104819,0.27084254609399,-1.12931795083553,-5.3368900355842,-0.469347989453005,"MBTD1","mbt domain containing 1",TRUE
+"207115_x_at",0.904381089098038,0.607509825708688,-0.521036923634636,-5.80831390923346,-0.236605223194086,"MBTD1","mbt domain containing 1",TRUE
+"201620_at",0.669423128374382,0.135549765966763,-1.54899308563496,-4.83407690343541,-0.562020437490252,"MBTPS1","membrane bound transcription factor peptidase, site 1",TRUE
+"217543_s_at",0.841550580403629,0.433072574021536,-0.798471655326705,-5.63383425004281,-0.283139160154635,"MBTPS1","membrane bound transcription factor peptidase, site 1",TRUE
+"206473_at",0.685874099002302,0.154185250129626,-1.47536189397716,-4.93170318442716,-0.469106279665272,"MBTPS2","membrane bound transcription factor peptidase, site 2",TRUE
+"226760_at",0.6916203275371,0.16123260530019,-1.44940243551591,-4.9652085246848,-0.486697730900763,"MBTPS2","membrane bound transcription factor peptidase, site 2",TRUE
+"1554604_at",0.817889575750373,0.370808726972448,0.913509399516864,-5.54120332548866,0.515019659974358,"MBTPS2","membrane bound transcription factor peptidase, site 2",TRUE
+"205458_at",0.632949074657601,0.104194921943323,1.6944320959511,-4.63038027443044,0.859425608297162,"MC1R","melanocortin 1 receptor",TRUE
+"217425_at",0.913221029035633,0.63585955000196,-0.480103587565629,-5.82803502489928,-0.231976743784019,"MC2R","melanocortin 2 receptor",TRUE
+"217434_at",0.943294768503521,0.745371081548379,0.328831253689097,-5.88715414277929,0.200349115410127,"MC2R","melanocortin 2 receptor",TRUE
+"208568_at",0.973372948129726,0.871190707626454,-0.164035061890859,-5.92658632039321,-0.0787249547481519,"MC2R","melanocortin 2 receptor",TRUE
+"221442_at",0.933400538871064,0.705440824274899,0.382902558866217,-5.8685242321471,0.293906548555897,"MC3R","melanocortin 3 receptor",TRUE
+"221467_at",0.768852835478002,0.272243654917345,1.12592930841477,-5.34039659142064,0.514463379104481,"MC4R","melanocortin 4 receptor",TRUE
+"208565_at",0.985498770484702,0.929940232989842,-0.0889252340692479,-5.93583266679074,-0.0564900645039597,"MC5R","melanocortin 5 receptor",TRUE
+"209087_x_at",0.442754081224941,0.0206011226819616,2.49340615287517,-3.29471177106113,2.47193163135878,"MCAM","melanoma cell adhesion molecule",TRUE
+"1568191_at",0.602822122207901,0.0773562058022574,1.85227736650595,-4.39393097042878,1.18078107381679,"MCAM","melanoma cell adhesion molecule",TRUE
+"213132_s_at",0.970526265934304,0.85938055137863,-0.179237021315077,-5.92404823729197,-0.0716476193019524,"MCAT","malonyl-CoA-acyl carrier protein transacylase",TRUE
+"226225_at",0.622434989367596,0.0926318582715295,1.75756327238553,-4.53766574474519,1.38937630390189,"MCC","mutated in colorectal cancers",TRUE
+"206132_at",0.682125064335234,0.149634886050768,1.49263972917776,-4.90913684098931,0.515661944825599,"MCC","mutated in colorectal cancers",TRUE
+"218440_at",0.914049722632229,0.638873528127858,-0.475801521682742,-5.83001617879932,-0.21782419962234,"MCCC1","methylcrotonoyl-CoA carboxylase 1",TRUE
+"209624_s_at",0.565993041605217,0.0568983503987042,-2.00879350339952,-4.14486903496797,-0.99675426337304,"MCCC2","methylcrotonoyl-CoA carboxylase 2",TRUE
+"209623_at",0.662015916975184,0.130008418386493,-1.5724924167721,-4.80212707373868,-0.718384256734408,"MCCC2","methylcrotonoyl-CoA carboxylase 2",TRUE
+"1560033_at",0.896118635245982,0.578285062151179,-0.564200164858578,-5.78581873474837,-0.495800870175,"MCCC2","methylcrotonoyl-CoA carboxylase 2",TRUE
+"226238_at",0.955645941042265,0.797041613835848,0.260292797641899,-5.90673758553659,0.115290162888144,"MCEE","methylmalonyl-CoA epimerase",TRUE
+"235568_at",0.589219738108056,0.0677470946687667,1.92057692309215,-4.28696237155496,0.9733399504008,"MCEMP1","mast cell expressed membrane protein 1",TRUE
+"217004_s_at",0.675622576285316,0.141924218999196,1.52292179560313,-4.86907801786013,1.12640399473398,"MCF2","MCF.2 cell line derived transforming sequence",TRUE
+"1555313_a_at",0.80818658267298,0.349969096016297,0.954823571641128,-5.50512943210772,0.908165075804829,"MCF2","MCF.2 cell line derived transforming sequence",TRUE
+"214884_at",0.869971289491322,0.508046134087399,-0.672776429568185,-5.72159740555437,-0.517904476201577,"MCF2","MCF.2 cell line derived transforming sequence",TRUE
+"208017_s_at",0.974536463688956,0.875603029872849,0.15836588200509,-5.92747543548846,0.0900138012119518,"MCF2","MCF.2 cell line derived transforming sequence",TRUE
+"212935_at",0.606138724709726,0.0798066437107559,-1.83605061836728,-4.4189415877188,-2.2304281928744,"MCF2L","MCF.2 cell line derived transforming sequence like",TRUE
+"1552743_at",0.615637099066718,0.0860269676008325,1.79672207650147,-4.47890272830049,1.07065414302867,"MCF2L","MCF.2 cell line derived transforming sequence like",TRUE
+"239636_at",0.643082025527735,0.113353615806934,-1.64852499878453,-4.69619275089948,-1.52263668170232,"MCF2L","MCF.2 cell line derived transforming sequence like",TRUE
+"1559427_at",0.737123149977386,0.223143084865246,-1.25335103799596,-5.20222145402816,-0.965522797514856,"MCF2L","MCF.2 cell line derived transforming sequence like",TRUE
+"1563808_at",0.80764044633141,0.349070912244198,0.956641028733273,-5.50350890531291,0.507558219393186,"MCF2L","MCF.2 cell line derived transforming sequence like",TRUE
+"35147_at",0.839519981963042,0.427550558984748,-0.808231211779014,-5.6264275857654,-0.602073131228494,"MCF2L","MCF.2 cell line derived transforming sequence like",TRUE
+"1563809_a_at",0.902695356210077,0.602094087796417,-0.528957977181698,-5.80431612767459,-0.361832913540248,"MCF2L","MCF.2 cell line derived transforming sequence like",TRUE
+"220464_at",0.94943075115007,0.77165905624552,-0.293781725920247,-5.89773339027026,-0.262248882305834,"MCF2L","MCF.2 cell line derived transforming sequence like",TRUE
+"220354_at",0.868397087637799,0.504052410853771,-0.679188321610123,-5.71746633178435,-0.487735033888669,"MCF2L-AS1","MCF2L antisense RNA 1",TRUE
+"215112_x_at",0.812302873476553,0.360495238848818,0.93375537550714,-5.52370852601724,1.27902893363833,"MCF2L2","MCF.2 cell line derived transforming sequence-like 2",TRUE
+"1559309_at",0.527826453640453,0.0403800855588631,2.17735679565011,-3.86178662504283,0.971913015820435,"MCFD2","multiple coagulation factor deficiency 2",TRUE
+"212246_at",0.630603891142543,0.10200385575244,1.70591956062649,-4.6136984004655,0.85984097042696,"MCFD2","multiple coagulation factor deficiency 2",TRUE
+"212245_at",0.860085676417428,0.479218781183143,0.719723878506272,-5.69048474697994,0.339729275403405,"MCFD2","multiple coagulation factor deficiency 2",TRUE
+"223855_s_at",0.933448396773721,0.705576047781882,-0.382717564319094,-5.86859273355284,-0.236025223056058,"MCHR1","melanin concentrating hormone receptor 1",TRUE
+"230498_at",0.945664467195782,0.754753879633995,0.316275291048119,-5.89107962355727,0.263492575669647,"MCHR1","melanin concentrating hormone receptor 1",TRUE
+"221354_s_at",0.975552150564853,0.883608479200231,-0.14809348196638,-5.92900701054783,-0.126652108656916,"MCHR1","melanin concentrating hormone receptor 1",TRUE
+"224408_at",0.974982245454858,0.87861637340295,-0.154497245141436,-5.92806425955563,-0.104547986062335,"MCHR2","melanin concentrating hormone receptor 2",TRUE
+"231129_at",0.897375964261386,0.583897210138356,0.555829421634131,-5.7903171226188,0.235100637670532,"MCHR2-AS1","MCHR2 antisense RNA 1",TRUE
+"1561437_at",0.988065316951061,0.943017365317726,-0.0722929968017551,-5.93713827428494,-0.0819351382554627,"MCHR2-AS1","MCHR2 antisense RNA 1",TRUE
+"200797_s_at",0.697412165374288,0.167801182323467,-1.42601872456424,-4.99497438932834,-0.498742722158296,"MCL1","BCL2 family apoptosis regulator",TRUE
+"227175_at",0.831312224296633,0.405476623640468,-0.848053886590747,-5.59533249438724,-0.654144941946941,"MCL1","BCL2 family apoptosis regulator",TRUE
+"200798_x_at",0.84176002413858,0.433696934247532,-0.797373029658588,-5.63466271662976,-0.301016423446974,"MCL1","BCL2 family apoptosis regulator",TRUE
+"214057_at",0.89748872632674,0.584274599448998,0.55526797483264,-5.7906165058091,0.219590223527467,"MCL1","BCL2 family apoptosis regulator",TRUE
+"200796_s_at",0.947969282616012,0.763394381911034,-0.304758414560052,-5.89454715358594,-0.141157396592462,"MCL1","BCL2 family apoptosis regulator",TRUE
+"214056_at",0.983364220761052,0.918893760988095,-0.102994621200193,-5.93451808808863,-0.0575697462921454,"MCL1","BCL2 family apoptosis regulator",TRUE
+"220651_s_at",0.774230543658252,0.290326393844294,1.08329387715338,-5.38371616331989,0.379752193395419,"MCM10","minichromosome maintenance 10 replication initiation factor",TRUE
+"223570_at",0.822819707575556,0.38804583739983,0.880488293114331,-5.56897690751157,0.298115408662751,"MCM10","minichromosome maintenance 10 replication initiation factor",TRUE
+"222962_s_at",0.88020017258149,0.535589932174003,0.629296995199247,-5.74861842360154,0.19282726493423,"MCM10","minichromosome maintenance 10 replication initiation factor",TRUE
+"202107_s_at",0.93032716386748,0.691955569170414,-0.401421020839917,-5.86150200470762,-0.13656355583722,"MCM2","minichromosome maintenance complex component 2",TRUE
+"201555_at",0.920077265976268,0.659619792240304,0.446429357239116,-5.84307564912211,0.173658304956026,"MCM3","minichromosome maintenance complex component 3",TRUE
+"212269_s_at",0.68211027944894,0.149558994605101,-1.49293149733446,-4.90875395123627,-0.578107108407645,"MCM3AP","minichromosome maintenance complex component 3 associated protein",TRUE
+"214514_at",0.730101539866086,0.212747961379009,1.28300849650846,-5.16823096442092,0.565446927013953,"MCM3AP","minichromosome maintenance complex component 3 associated protein",TRUE
+"215580_at",0.744573608322482,0.235556109466197,1.21928917887117,-5.24041649917267,0.719272693797306,"MCM3AP","minichromosome maintenance complex component 3 associated protein",TRUE
+"215582_x_at",0.885550062409064,0.547164108835308,0.611389387994129,-5.75924254113599,0.195422306432526,"MCM3AP","minichromosome maintenance complex component 3 associated protein",TRUE
+"215581_s_at",0.942671206410999,0.742776112629547,-0.332313266052311,-5.88603874514636,-0.0899391492211681,"MCM3AP","minichromosome maintenance complex component 3 associated protein",TRUE
+"232740_at",0.978584438847921,0.896503263968057,0.131580955535936,-5.9312542066605,0.0608338514284652,"MCM3AP-AS1","MCM3AP antisense RNA 1",TRUE
+"220459_at",0.992342196993659,0.964073409416854,-0.0455545201766049,-5.93867277091808,-0.0208317139544683,"MCM3AP-AS1","MCM3AP antisense RNA 1",TRUE
+"1560542_at",0.999273244594744,0.997639505257117,0.00299200438217832,-5.93967912051696,0.0025094351908308,"MCM3AP-AS1","MCM3AP antisense RNA 1",TRUE
+"242479_s_at",0.597654932724127,0.0742087836624008,-1.87378927254994,-4.36053355050604,-1.02084838141957,"MCM4","minichromosome maintenance complex component 4",TRUE
+"222036_s_at",0.899798994481376,0.591621327655946,-0.544373730824144,-5.79636753017365,-0.158839715858157,"MCM4","minichromosome maintenance complex component 4",TRUE
+"212142_at",0.94895689004559,0.769384754028911,0.296798598711291,-5.8968692200336,0.117675648848504,"MCM4","minichromosome maintenance complex component 4",TRUE
+"222037_at",0.958634784686666,0.812424350859467,-0.240146818294887,-5.91163328061501,-0.0828108876044187,"MCM4","minichromosome maintenance complex component 4",TRUE
+"212141_at",0.998038817582822,0.99095397586212,-0.0114663765281899,-5.93961944296768,-0.00489515285566533,"MCM4","minichromosome maintenance complex component 4",TRUE
+"216237_s_at",0.953983577550391,0.787936293781215,-0.272269089461754,-5.90364162829467,-0.10205959238175,"MCM5","minichromosome maintenance complex component 5",TRUE
+"201755_at",0.989638901366417,0.949976164146647,-0.0634512185954805,-5.93772272699379,-0.0244427360150095,"MCM5","minichromosome maintenance complex component 5",TRUE
+"238977_at",0.466300647363886,0.0243554110793747,-2.41634240258341,-3.43695829002618,-0.810109770811335,"MCM6","minichromosome maintenance complex component 6",TRUE
+"201930_at",0.655745626967443,0.124308363886989,-1.59754819239795,-4.76764633325992,-0.411922111332052,"MCM6","minichromosome maintenance complex component 6",TRUE
+"210983_s_at",0.929786324276714,0.690150109380659,-0.403911080371829,-5.86053286234614,-0.201062017186402,"MCM7","minichromosome maintenance complex component 7",TRUE
+"208795_s_at",0.993892931327222,0.971442857798386,-0.0362053213694818,-5.93904504624522,-0.0151671603170929,"MCM7","minichromosome maintenance complex component 7",TRUE
+"233560_x_at",0.774230543658252,0.287900584268666,1.08889972064285,-5.37810530030428,0.445633262600888,"MCM8","minichromosome maintenance 8 homologous recombination repair factor",TRUE
+"224320_s_at",0.992719003179959,0.965701794643483,0.0434883524631609,-5.93876237101446,0.0173320028748645,"MCM8","minichromosome maintenance 8 homologous recombination repair factor",TRUE
+"1557334_a_at",0.407748633394319,0.0156106269128238,2.6191933902647,-3.05759801429184,0.964231010983593,"MCM8-AS1","MCM8 antisense RNA 1",TRUE
+"213561_at",0.535697382361465,0.0429518100678262,2.147435839163,-3.91309427804671,0.802691186291439,"MCM9","minichromosome maintenance 9 homologous recombination repair factor",TRUE
+"1553759_at",0.610033432202476,0.0823714796871149,1.81952332599302,-4.44425338319799,0.682527056571075,"MCM9","minichromosome maintenance 9 homologous recombination repair factor",TRUE
+"219673_at",0.920147736488699,0.660119380430027,0.445727047864528,-5.84337792738263,0.203840886094122,"MCM9","minichromosome maintenance 9 homologous recombination repair factor",TRUE
+"233028_at",0.653206225743412,0.122638878421449,1.60506778169538,-4.75721538097409,1.18226102002785,"MCMBP","minichromosome maintenance complex binding protein",TRUE
+"222464_s_at",0.832605695407954,0.409351705061516,0.840965498810294,-5.60096964127468,0.286478069372794,"MCMBP","minichromosome maintenance complex binding protein",TRUE
+"217905_at",0.929234395612144,0.688941551127898,0.405579355405545,-5.85988026195923,0.142515891352822,"MCMBP","minichromosome maintenance complex binding protein",TRUE
+"1569677_a_at",0.637485146909712,0.108886964435311,1.67050565651996,-4.66485247613943,1.42293142978255,"MCMDC2","minichromosome maintenance domain containing 2",TRUE
+"1552359_at",0.895690630367785,0.576268962424595,0.567217199848295,-5.78418141127951,0.51397686233641,"MCMDC2","minichromosome maintenance domain containing 2",TRUE
+"219952_s_at",0.740476003158683,0.229210061121778,1.23652774589518,-5.22119945943721,0.606639457140213,"MCOLN1","mucolipin 1",TRUE
+"1555465_at",0.854400503339099,0.465344414441814,-0.742903702260079,-5.67438732221431,-0.37163241011499,"MCOLN2","mucolipin 2",TRUE
+"230110_at",0.913300726876965,0.63650732874518,-0.479178193807585,-5.82846265248156,-0.434938406234963,"MCOLN2","mucolipin 2",TRUE
+"220484_at",0.640067422642767,0.110682319302793,1.66158080087416,-4.67761577538914,1.73863856629545,"MCOLN3","mucolipin 3",TRUE
+"229797_at",0.647741963817785,0.118850432208871,1.62245391191764,-4.73295261059578,1.34318477301442,"MCOLN3","mucolipin 3",TRUE
+"1557292_a_at",0.783862955202613,0.306812075334067,1.04605908944706,-5.42032616402646,0.750422090358314,"MCOLN3","mucolipin 3",TRUE
+"242308_at",0.965620759643697,0.839369078599698,0.205096718380494,-5.91921607716087,0.0752744015789117,"MCOLN3","mucolipin 3",TRUE
+"232243_at",0.51531387545335,0.0356345073074466,2.23741864328339,-3.7574801381918,1.60398821708449,"MCPH1","microcephalin 1",TRUE
+"219592_at",0.759884556197805,0.257727509531309,-1.16167949429161,-5.30293505519439,-0.800762186363598,"MCPH1","microcephalin 1",TRUE
+"1557347_at",0.798428326317339,0.332811659905948,-0.990107614225237,-5.47316605517701,-0.750151819690561,"MCPH1","microcephalin 1",TRUE
+"228778_at",0.872540606821582,0.515883296387004,0.660275439405472,-5.72954367028173,0.302507080393098,"MCPH1","microcephalin 1",TRUE
+"1554155_at",0.954490024544918,0.79145422501634,0.267637203749582,-5.9048554035113,0.082708069047805,"MCPH1","microcephalin 1",TRUE
+"230562_at",0.91876780831279,0.654930873400442,0.453032117754608,-5.84021096045734,0.251178091223489,"MCPH1-AS1","MCPH1 antisense RNA 1",TRUE
+"239642_at",0.744931128252932,0.236537920704858,-1.21665368654118,-5.24333391268207,-0.79145669694236,"MCPH1-AS1///MCPH1","MCPH1 antisense RNA 1///microcephalin 1",TRUE
+"225329_at",0.943010360246042,0.744315711766766,-0.330246879948765,-5.88670207580188,-0.202292588617954,"MCRIP1","MAPK regulated corepressor interacting protein 1",TRUE
+"225861_at",0.562645942149434,0.0553431073041664,-2.02264224655652,-4.12217283781477,-0.658425034809424,"MCRIP2","MAPK regulated corepressor interacting protein 2",TRUE
+"1553715_s_at",0.571677937624457,0.0594506020947214,-1.98677937553611,-4.18073238333929,-0.681210240384468,"MCRIP2","MAPK regulated corepressor interacting protein 2",TRUE
+"202556_s_at",0.7768734672127,0.294790078737435,-1.07306603320467,-5.39388653660356,-0.317988307527827,"MCRS1","microspherule protein 1",TRUE
+"235740_at",0.615821255316333,0.086244986788385,1.79538880575029,-4.4809190016579,1.66690215747108,"MCTP1","multiple C2 and transmembrane domain containing 1",TRUE
+"220122_at",0.623503825356688,0.09440284484995,1.74747224658384,-4.55265444418786,2.01604797313823,"MCTP1","multiple C2 and transmembrane domain containing 1",TRUE
+"1554730_at",0.63418824799514,0.104998078339164,1.6902725944894,-4.63639969666149,0.614137430855002,"MCTP1","multiple C2 and transmembrane domain containing 1",TRUE
+"243109_at",0.323645710780045,0.0073686210678204,2.94990486552323,-2.408939613501,1.52741320529062,"MCTP2","multiple C2 and transmembrane domain containing 2",TRUE
+"229005_at",0.446720401893991,0.0209613998106256,2.4854676369815,-3.30947466291596,1.47439665480629,"MCTP2","multiple C2 and transmembrane domain containing 2",TRUE
+"1554833_at",0.567651250567208,0.0576736171670912,2.00201536651468,-4.15593954984539,1.45541748799281,"MCTP2","multiple C2 and transmembrane domain containing 2",TRUE
+"220603_s_at",0.571677937624457,0.0595191405900375,1.98619985150212,-4.18167290152686,1.10764763607617,"MCTP2","multiple C2 and transmembrane domain containing 2",TRUE
+"229021_at",0.913169843988782,0.635719867795977,0.480303188338084,-5.82794268291715,0.240376392930375,"MCTP2","multiple C2 and transmembrane domain containing 2",TRUE
+"230235_at",0.871451481476429,0.512488698659309,-0.665677041681546,-5.72612765552752,-0.245406982285814,"MCTS1","MCTS1, re-initiation and release factor",TRUE
+"218163_at",0.905462783815257,0.611545549812768,-0.515156175238223,-5.81124393418324,-0.188118361545621,"MCTS1","MCTS1, re-initiation and release factor",TRUE
+"1558573_at",0.945251068482575,0.752743146259375,-0.318961600089815,-5.89025250131563,-0.122041930766377,"MCTS1","MCTS1, re-initiation and release factor",TRUE
+"225320_at",0.615951180787902,0.0870611929607481,1.79042307791829,-4.48841897987046,0.732260516585701,"MCU","mitochondrial calcium uniporter",TRUE
+"218802_at",0.87579870142401,0.523473950201224,0.648267670202085,-5.73704182929953,0.296595250660037,"MCUB","mitochondrial calcium uniporter dominant negative beta subunit",TRUE
+"220094_s_at",0.642613985059507,0.113133096099141,1.64959290278805,-4.69467744464626,0.608567172785408,"MCUR1","mitochondrial calcium uniporter regulator 1",TRUE
+"227451_s_at",0.757950630724418,0.254300969656565,1.17033453694789,-5.29371114071998,0.434344543660504,"MCUR1","mitochondrial calcium uniporter regulator 1",TRUE
+"203061_s_at",0.962351204352784,0.828563705417521,0.219118453006824,-5.91632518881032,0.119978543323791,"MDC1","mediator of DNA damage checkpoint 1",TRUE
+"203062_s_at",0.998347572104896,0.992173287552137,-0.00992076892584723,-5.93963554330288,-0.00378189555388353,"MDC1","mediator of DNA damage checkpoint 1",TRUE
+"205375_at",0.329593230108883,0.00789094720096074,2.92023077889634,-2.46845718028159,2.62550650904301,"MDFI","MyoD family inhibitor",TRUE
+"239172_x_at",0.605901842250435,0.0792686946066276,1.83957542871677,-4.41352208097759,1.37564717732447,"MDFIC","MyoD family inhibitor domain containing",TRUE
+"217599_s_at",0.643515428391208,0.114004729055247,1.64538204393671,-4.70064810065805,2.00483001712476,"MDFIC","MyoD family inhibitor domain containing",TRUE
+"211675_s_at",0.694519360341564,0.164055190467513,1.43926197058035,-4.97816518864388,1.96310973570064,"MDFIC","MyoD family inhibitor domain containing",TRUE
+"1559942_at",0.751448178921747,0.244325455449326,1.19603643588455,-5.26596758481562,1.09652737218461,"MDFIC","MyoD family inhibitor domain containing",TRUE
+"232237_at",0.325914865754316,0.0074809905170858,2.94335468605165,-2.4220974205923,1.95382997792992,"MDGA1","MAM domain containing glycosylphosphatidylinositol anchor 1",TRUE
+"238543_x_at",0.789595899448337,0.316921481726452,-1.02392321247624,-5.44154479047042,-0.51983389932159,"MDGA1","MAM domain containing glycosylphosphatidylinositol anchor 1",TRUE
+"242757_at",0.945498722604777,0.754299459013303,-0.316882181681606,-5.89089336597342,-0.20748250534757,"MDGA1","MAM domain containing glycosylphosphatidylinositol anchor 1",TRUE
+"239935_at",0.852153111602676,0.457825333091435,0.755637175646531,-5.66533862670408,0.891663646838838,"MDGA2","MAM domain containing glycosylphosphatidylinositol anchor 2",TRUE
+"1570114_at",0.910057872239721,0.625628603120744,-0.49477637032702,-5.82114692952333,-0.393760953480648,"MDGA2","MAM domain containing glycosylphosphatidylinositol anchor 2",TRUE
+"200978_at",0.930827859648584,0.693498096017157,0.399295638420267,-5.86232454526437,0.0949788018080646,"MDH1","malate dehydrogenase 1",TRUE
+"238721_at",0.956398858120188,0.80248304871091,-0.253154279456052,-5.90851713911441,-0.104515275842861,"MDH1B","malate dehydrogenase 1B",TRUE
+"1558077_s_at",0.994217597763908,0.973706707278314,-0.0333340081503335,-5.93914229207283,-0.0260537225407322,"MDH1B","malate dehydrogenase 1B",TRUE
+"213333_at",0.841967750949524,0.434305678719307,-0.796302822107191,-5.6354687219124,-0.294409153443711,"MDH2","malate dehydrogenase 2",TRUE
+"209036_s_at",0.851733415458562,0.456138419503997,-0.758511098109979,-5.6632762194696,-0.202032743532465,"MDH2","malate dehydrogenase 2",TRUE
+"209035_at",0.765934384067577,0.266308286474422,1.14037311500072,-5.32538553330396,2.04116222171914,"MDK","midkine (neurite growth-promoting factor 2)",TRUE
+"213761_at",0.849144743801275,0.449916022837523,-0.769167640886266,-5.65556419160291,-0.256890624802214,"MDM1","Mdm1 nuclear protein",TRUE
+"220397_at",0.940044918888428,0.731283077884587,-0.347786166524666,-5.88094175768563,-0.13844088961936,"MDM1","Mdm1 nuclear protein",TRUE
+"205385_at",0.411110107932987,0.0161840763209786,-2.60295939952571,-3.08852694035472,-0.891641612073537,"MDM2","MDM2 proto-oncogene",TRUE
+"211832_s_at",0.55937703282623,0.0532196763970458,2.04212101017362,-4.09007510334077,1.39237584843762,"MDM2","MDM2 proto-oncogene",TRUE
+"229711_s_at",0.61760967235709,0.0879520775911442,-1.78504862813327,-4.49651922828376,-0.751028350752447,"MDM2","MDM2 proto-oncogene",TRUE
+"244616_x_at",0.627942883677571,0.0993576213863987,-1.72007662070742,-4.59302363629922,-0.777114785182928,"MDM2","MDM2 proto-oncogene",TRUE
+"225160_x_at",0.65284137151906,0.121595994416963,-1.60980854070398,-4.75061960576702,-0.683846027331104,"MDM2","MDM2 proto-oncogene",TRUE
+"238733_at",0.766550448794594,0.267704404969947,-1.13695455349099,-5.32895360052042,-0.916666826724789,"MDM2","MDM2 proto-oncogene",TRUE
+"217373_x_at",0.806221445484273,0.34696542731939,-0.960913918209089,-5.49968789932394,-0.452259055359856,"MDM2","MDM2 proto-oncogene",TRUE
+"217542_at",0.903615659612912,0.604977559226579,-0.52473638288951,-5.80645408998322,-0.417759287492641,"MDM2","MDM2 proto-oncogene",TRUE
+"237891_at",0.955730092376044,0.797654544439861,0.259488021216443,-5.90694066636125,0.216653758284666,"MDM2","MDM2 proto-oncogene",TRUE
+"205386_s_at",0.990810941805126,0.954055869247071,0.0582700427141549,-5.93802984293951,0.037129447931946,"MDM2","MDM2 proto-oncogene",TRUE
+"235162_at",0.27079015774099,0.0042395313219257,-3.18653268962245,-1.92665402074158,-0.999385067797737,"MDM4","MDM4, p53 regulator",TRUE
+"225740_x_at",0.429960090499345,0.0190482204346383,-2.52917530233264,-3.22788975246148,-0.813601944815064,"MDM4","MDM4, p53 regulator",TRUE
+"225742_at",0.522339938465752,0.038099527656176,-2.20537084796339,-3.81335152470189,-0.650642264497957,"MDM4","MDM4, p53 regulator",TRUE
+"236814_at",0.593359853748923,0.0705411806011522,-1.89988568139896,-4.31965455569062,-0.725281771647001,"MDM4","MDM4, p53 regulator",TRUE
+"241876_at",0.767727587789514,0.269985569586149,1.13139691762638,-5.33473412062114,0.418874987460851,"MDM4","MDM4, p53 regulator",TRUE
+"205655_at",0.968981107202359,0.85366039271556,-0.18661531548342,-5.92273559370305,-0.099326697483094,"MDM4","MDM4, p53 regulator",TRUE
+"212693_at",0.571833476034523,0.0599159743058273,1.98285602210443,-4.18709603898301,0.635658269266054,"MDN1","midasin AAA ATPase 1",TRUE
+"1569484_s_at",0.725583196024696,0.204329238449664,1.30785781396086,-5.13923044063926,0.952458861906266,"MDN1","midasin AAA ATPase 1",TRUE
+"234854_at",0.731054546207485,0.213864796900781,1.27976939132842,-5.17197631893885,0.447187834301748,"MDN1","midasin AAA ATPase 1",TRUE
+"1562731_s_at",0.547343369043481,0.0478979833710465,2.0941726678999,-4.003317688558,0.829106251459052,"MDS2","myelodysplastic syndrome 2 translocation associated",TRUE
+"1553508_at",0.960614707352139,0.821168171081554,0.228741155307751,-5.91423119603604,0.121138695371061,"MDS2","myelodysplastic syndrome 2 translocation associated",TRUE
+"211204_at",0.682504456039784,0.150056787501355,-1.49101990548834,-4.91126145485531,-1.23098196474013,"ME1","malic enzyme 1",TRUE
+"204059_s_at",0.725168361556674,0.203444047745458,1.31051649006007,-5.13609970408971,1.84756182596508,"ME1","malic enzyme 1",TRUE
+"204058_at",0.752913428584105,0.246219428707122,1.1910970443224,-5.27134012622844,2.48151174864791,"ME1","malic enzyme 1",TRUE
+"210153_s_at",0.842224301155785,0.43563460086097,-0.793969714154986,-5.63722232572079,-0.342481043163723,"ME2","malic enzyme 2",TRUE
+"210154_at",0.969270009913181,0.854193073339096,-0.185927782267902,-5.92286013967685,-0.0831422046011738,"ME2","malic enzyme 2",TRUE
+"209397_at",0.983679139992471,0.920357257477719,-0.101129471295533,-5.934703430687,-0.04381671064926,"ME2","malic enzyme 2",TRUE
+"204663_at",0.588653540532996,0.0672739135454935,1.92415496594849,-4.28128416311698,2.09518838381532,"ME3","malic enzyme 3",TRUE
+"231295_at",0.7916581936323,0.322338228155048,1.01226598372407,-5.4525542029511,0.589627730693167,"ME3","malic enzyme 3",TRUE
+"218061_at",0.807167370609991,0.348481115053949,-0.957836198744482,-5.50244170087174,-0.304736202472595,"MEA1","male-enhanced antigen 1",TRUE
+"228517_at",0.62110896023334,0.0917073424871846,-1.76289703725033,-4.52971756005434,-0.832627436911571,"MEAF6","MYST/Esa1 associated factor 6",TRUE
+"218165_at",0.832605695407954,0.409277440068423,-0.841100943516024,-5.60086234077378,-0.266616594899546,"MEAF6","MYST/Esa1 associated factor 6",TRUE
+"230293_at",0.894272567245808,0.570682471765405,-0.575605203380763,-5.77958483533324,-0.176664333322786,"MEAF6","MYST/Esa1 associated factor 6",TRUE
+"221884_at",0.726636642789909,0.206027799475534,1.30278114434533,-5.14519354491328,1.70481333535962,"MECOM","MDS1 and EVI1 complex locus",TRUE
+"226420_at",0.735677568529031,0.220695305843336,1.26023756675997,-5.19438941732427,1.37025782498838,"MECOM","MDS1 and EVI1 complex locus",TRUE
+"208434_at",0.782206338814045,0.304187156743941,-1.05189075895147,-5.41466819129077,-0.651670313043059,"MECOM","MDS1 and EVI1 complex locus",TRUE
+"215851_at",0.876632890672003,0.525550390556999,0.644999621114302,-5.73905966656085,0.424795762323481,"MECOM","MDS1 and EVI1 complex locus",TRUE
+"243277_x_at",0.935094665155941,0.71157774273715,-0.374520427575596,-5.87159526688479,-0.30989709545047,"MECOM","MDS1 and EVI1 complex locus",TRUE
+"202617_s_at",0.379201731949567,0.0116611776807884,-2.74920843821348,-2.80663282211366,-0.862324820968255,"MECP2","methyl-CpG binding protein 2",TRUE
+"202616_s_at",0.581367983493308,0.0638150668237675,-1.9510039755305,-4.23844388829648,-0.588769940225852,"MECP2","methyl-CpG binding protein 2",TRUE
+"202618_s_at",0.894538680437601,0.571112721996692,-0.574957714550202,-5.77994198354227,-0.171080721085737,"MECP2","methyl-CpG binding protein 2",TRUE
+"218664_at",0.97689149311934,0.889829146383702,0.140122579536599,-5.93012484136296,0.0399991108830058,"MECR","mitochondrial trans-2-enoyl-CoA reductase",TRUE
+"203496_s_at",0.8920930097751,0.563582752364317,0.586325901448862,-5.7736148531321,0.785354115881101,"MED1","mediator complex subunit 1",TRUE
+"225456_at",0.929972194057784,0.69101888768445,-0.402712552704341,-5.8610000711808,-0.307487679466414,"MED1","mediator complex subunit 1",TRUE
+"225452_at",0.989627445997672,0.949710761384106,0.063788336976992,-5.9377018385967,0.0537672403607363,"MED1","mediator complex subunit 1",TRUE
+"203497_at",0.993225426079816,0.968406804824376,-0.0400565393394457,-5.93890200534305,-0.028393915874128,"MED1","mediator complex subunit 1",TRUE
+"223247_at",0.580630437263151,0.0632137719594346,1.95580184553601,-4.23074557599822,0.960511217916974,"MED10","mediator complex subunit 10",TRUE
+"226958_s_at",0.624520459874487,0.0961328262956677,1.73777021497002,-4.56700515513876,0.551482064831616,"MED11","mediator complex subunit 11",TRUE
+"211342_x_at",0.697172073261335,0.167088982441289,-1.42851815342757,-4.99181168477565,-0.408926147491986,"MED12","mediator complex subunit 12",TRUE
+"203506_s_at",0.742286839825305,0.232660483500862,-1.22711067489272,-5.23172619805698,-0.448701374094892,"MED12","mediator complex subunit 12",TRUE
+"216071_x_at",0.837368340567858,0.420951173447678,-0.8199984328659,-5.61738501789392,-0.252559329357252,"MED12","mediator complex subunit 12",TRUE
+"214275_at",0.973615804712521,0.873053258516917,0.161641299868128,-5.92696554603367,0.150980767600096,"MED12","mediator complex subunit 12",TRUE
+"232114_at",0.864894115958506,0.493931471702938,-0.695567211607625,-5.70674370312675,-0.570179375939559,"MED12L","mediator complex subunit 12 like",TRUE
+"1555300_a_at",0.919481699308214,0.657840534557517,0.448932452735239,-5.84199450479435,0.180321239693533,"MED12L","mediator complex subunit 12 like",TRUE
+"244611_at",0.832605695407954,0.409253350782127,0.841144880981718,-5.60082752965629,0.778805084453832,"MED13","mediator complex subunit 13",TRUE
+"223780_s_at",0.923678893931092,0.672144279358801,0.428890265177738,-5.85048472595826,0.142039515956833,"MED13","mediator complex subunit 13",TRUE
+"201986_at",0.962377536390494,0.828687946953281,-0.218956979254063,-5.91635956302768,-0.0755129164308936,"MED13","mediator complex subunit 13",TRUE
+"201987_at",0.969450447163359,0.854523093394255,-0.185501869964285,-5.92293706344934,-0.0629422457193272,"MED13","mediator complex subunit 13",TRUE
+"212209_at",0.820611742812032,0.381226122861008,-0.893435277405912,-5.55820012897211,-0.459218920298376,"MED13L","mediator complex subunit 13 like",TRUE
+"242911_at",0.835952408568777,0.416314271382622,0.828335735860173,-5.61090407497305,0.493188152225443,"MED13L","mediator complex subunit 13 like",TRUE
+"216109_at",0.94333312187812,0.745762938576431,-0.328305808625054,-5.88732144968492,-0.195759673823861,"MED13L","mediator complex subunit 13 like",TRUE
+"212207_at",0.957571530817866,0.808970454451707,-0.244661071326198,-5.91057033201363,-0.146134163338933,"MED13L","mediator complex subunit 13 like",TRUE
+"212208_at",0.958587459575795,0.812299881482141,0.240309410997683,-5.91159533744601,0.097688133485784,"MED13L","mediator complex subunit 13 like",TRUE
+"202612_s_at",0.812302873476553,0.360293597598909,0.934155044797191,-5.52335961663183,0.685003767250199,"MED14","mediator complex subunit 14",TRUE
+"202611_s_at",0.848923243270856,0.44941222581173,-0.770034336866824,-5.65493250345284,-0.368810481464903,"MED14","mediator complex subunit 14",TRUE
+"202610_s_at",0.937113154905832,0.720738055443656,-0.36205922261102,-5.87603680206723,-0.13388875691531,"MED14","mediator complex subunit 14",TRUE
+"217120_s_at",0.943464796017993,0.747176662520516,-0.326410913982454,-5.88792260350774,-0.0855643963492465,"MED14","mediator complex subunit 14",TRUE
+"215167_at",0.945764550538403,0.755119179114917,-0.315787511901161,-5.89122906893041,-0.0813503457628855,"MED14","mediator complex subunit 14",TRUE
+"231226_at",0.835359769097686,0.41461651676276,-0.831402982674139,-5.60850433478901,-0.532984931741882,"MED14OS","MED14 opposite strand",TRUE
+"222175_s_at",0.865854896594418,0.496049961350739,0.692123138750591,-5.70901866549958,0.272383141748758,"MED15","mediator complex subunit 15",TRUE
+"1561433_at",0.758966211371161,0.256450126229565,-1.16489597252223,-5.29951417124356,-0.862727046651096,"MED15P9","mediator complex subunit 15 pseudogene 9",TRUE
+"43544_at",0.84772210282622,0.446929963275785,-0.774313272222883,-5.65180397549148,-0.290531160782804,"MED16","mediator complex subunit 16",TRUE
+"221418_s_at",0.854350135157525,0.465217177039004,-0.743118153133605,-5.6742361349063,-0.422771288460558,"MED16","mediator complex subunit 16",TRUE
+"221938_x_at",0.896292432634083,0.580330946516376,0.561143957561902,-5.7874686826201,0.176253552143329,"MED16","mediator complex subunit 16",TRUE
+"221545_x_at",0.983326118527016,0.918691018874619,-0.103253034810115,-5.93449214228649,-0.0301527306884122,"MED16","mediator complex subunit 16",TRUE
+"221544_s_at",0.990739624391638,0.95310605190693,0.0594761478879474,-5.93796068456992,0.0336575205487195,"MED16","mediator complex subunit 16",TRUE
+"223115_at",0.803583569469174,0.342127450024754,0.970799481270684,-5.49078815506552,0.315751315683679,"MED17","mediator complex subunit 17",TRUE
+"232483_at",0.899808883319249,0.592560476362138,0.54298591340751,-5.79709220278833,0.232996286816449,"MED17","mediator complex subunit 17",TRUE
+"221517_s_at",0.94895689004559,0.769474797307572,0.296679102579249,-5.89690361570143,0.107715985058059,"MED17","mediator complex subunit 17",TRUE
+"226293_at",0.678190256514657,0.145598486163128,1.50832829227542,-4.88846347269241,0.560442690950154,"MED19","mediator complex subunit 19",TRUE
+"226300_at",0.70939075283402,0.182401218148314,1.37655894824547,-5.05661967205264,0.548342257085748,"MED19","mediator complex subunit 19",TRUE
+"206961_s_at",0.94118897722809,0.736824827336307,-0.340314821870307,-5.88343155683778,-0.119012008091126,"MED20","mediator complex subunit 20",TRUE
+"212872_s_at",0.955892698633978,0.800028407618235,-0.256372791047161,-5.90772088664891,-0.0872867759446159,"MED20","mediator complex subunit 20",TRUE
+"206593_s_at",0.637485146909712,0.108627543805542,-1.67180551920392,-4.66298922862291,-0.456416594159089,"MED22","mediator complex subunit 22",TRUE
+"223946_at",0.54295328972902,0.0458223361764016,2.11589181810064,-3.96670124744606,0.76039746471,"MED23","mediator complex subunit 23",TRUE
+"223947_s_at",0.89587869043805,0.57665585281365,-0.566637817845504,-5.7844964945627,-0.221042975636117,"MED23","mediator complex subunit 23",TRUE
+"242707_at",0.910888708415045,0.628423394630267,-0.490757392314626,-5.82305377491005,-0.367326717505637,"MED23","mediator complex subunit 23",TRUE
+"242706_s_at",0.953983577550391,0.787850362604254,0.272382306528792,-5.9036117011126,0.0984997768790361,"MED23","mediator complex subunit 23",TRUE
+"218846_at",0.957610494018084,0.809893657118586,-0.24345393761954,-5.9108564976815,-0.0812278961987154,"MED23","mediator complex subunit 23",TRUE
+"215337_at",0.90466378569832,0.608825541295887,-0.519117663580254,-5.80927372379892,-0.2823438579492,"MED24","mediator complex subunit 24",TRUE
+"208110_x_at",0.682539393883246,0.150287585514944,1.49013536320791,-4.91242086647964,0.905445589590093,"MED25","mediator complex subunit 25",TRUE
+"215897_at",0.916042382946954,0.645729561235566,-0.466049090849968,-5.8344426652928,-0.175609180109332,"MED25","mediator complex subunit 25",TRUE
+"1559593_a_at",0.743553048228796,0.234295683799633,1.22268476783249,-5.23664963109429,0.477091595823053,"MED26","mediator complex subunit 26",TRUE
+"231724_at",0.844024304281279,0.440328289992121,0.78576418147432,-5.64335127168605,0.490244110930189,"MED26","mediator complex subunit 26",TRUE
+"227538_at",0.957610494018084,0.809909912471591,-0.243432686249418,-5.91086152297034,-0.0645101676109814,"MED26","mediator complex subunit 26",TRUE
+"221598_s_at",0.654733425932336,0.123677856845527,-1.60037812521262,-4.76372520080021,-0.604819298616206,"MED27","mediator complex subunit 27",TRUE
+"51176_at",0.818396634299469,0.371650114915803,-0.911874328586534,-5.54260078704578,-0.2770848304247,"MED27","mediator complex subunit 27",TRUE
+"215371_at",0.936143408699214,0.715241817902684,-0.369528874667678,-5.87339220811424,-0.208217326856436,"MED27","mediator complex subunit 27",TRUE
+"233802_at",0.594005743610726,0.0710140251546481,1.8964554429619,-4.32505049043893,0.515710900339017,"MED28","mediator complex subunit 28",TRUE
+"228992_at",0.622434989367596,0.0929728392202975,-1.75560759251342,-4.54057558500359,-0.80116075907026,"MED28","mediator complex subunit 28",TRUE
+"222636_at",0.67842163564685,0.145750209497689,-1.50773218849267,-4.88925214368918,-0.570586481035894,"MED28","mediator complex subunit 28",TRUE
+"222635_s_at",0.697699759202153,0.168498747729039,-1.42357889389422,-4.99805730174869,-0.533289575016592,"MED28","mediator complex subunit 28",TRUE
+"224416_s_at",0.767219563914006,0.269210925170374,-1.13328031880742,-5.33277798741356,-0.467318439642597,"MED28","mediator complex subunit 28",TRUE
+"218438_s_at",0.914588178928864,0.64030160073056,0.473766313371212,-5.8309473379175,0.181197979514168,"MED28","mediator complex subunit 28",TRUE
+"227504_s_at",0.936992192746977,0.718994416354838,0.36442661963727,-5.87520440752761,0.103016703072427,"MED28","mediator complex subunit 28",TRUE
+"227505_at",0.944850801239076,0.752060336204274,0.319874367802345,-5.88996988073619,0.103071679423969,"MED28","mediator complex subunit 28",TRUE
+"235105_at",0.972819824894874,0.86829672095845,0.167756384577962,-5.92598573890526,0.0609857159299598,"MED28","mediator complex subunit 28",TRUE
+"243668_at",0.997056683282451,0.985171835603304,0.0187963112968161,-5.93951140216808,0.0129302677623544,"MED28","mediator complex subunit 28",TRUE
+"225708_at",0.617775129514679,0.088643408015481,-1.7809102614153,-4.50274437742199,-0.64304431164471,"MED29","mediator complex subunit 29",TRUE
+"227786_at",0.823274744098629,0.390079176122361,0.876656830787975,-5.57213815498055,0.411719566252355,"MED30","mediator complex subunit 30",TRUE
+"227787_s_at",0.87052412550512,0.509659717331917,0.670193862345885,-5.72325071461497,0.322470794114304,"MED30","mediator complex subunit 30",TRUE
+"230555_s_at",0.8920930097751,0.564260433032361,0.58529961222944,-5.77419097194177,0.378911370151757,"MED30","mediator complex subunit 30",TRUE
+"222867_s_at",0.352457014090632,0.00935372889703717,2.84615435958352,-2.61598179902859,1.23568058330785,"MED31","mediator complex subunit 31",TRUE
+"236241_at",0.587626678796111,0.0666260905768873,1.92908965178047,-4.27344103911621,0.960098785608296,"MED31","mediator complex subunit 31",TRUE
+"219318_x_at",0.694819513561858,0.164384952715214,1.43808645273009,-4.97966236945876,0.445642181406182,"MED31","mediator complex subunit 31",TRUE
+"222438_at",0.774230543658252,0.290274149071021,-1.08341425455657,-5.38359594951542,-0.457641913518078,"MED4","mediator complex subunit 4",TRUE
+"217843_s_at",0.996898592071515,0.984137908749509,0.0201071046408998,-5.93948656515931,0.00774508982847344,"MED4","mediator complex subunit 4",TRUE
+"210104_at",0.767011398042819,0.268632518234905,-1.13468919956553,-5.33131282198406,-0.385818197977832,"MED6","mediator complex subunit 6",TRUE
+"207079_s_at",0.827866702343255,0.397181969765408,-0.863373655295929,-5.58299860143706,-0.330821121159168,"MED6","mediator complex subunit 6",TRUE
+"207078_at",0.942246902934074,0.739976041500916,-0.336075198306153,-5.88482061764726,-0.207166088906463,"MED6","mediator complex subunit 6",TRUE
+"231272_at",0.827060995001753,0.39582232297093,0.865904417315027,-5.58094131358638,0.363247960337905,"MED7","mediator complex subunit 7",TRUE
+"204349_at",0.9089753392553,0.621750998528028,-0.500366191727914,-5.81846953156305,-0.166628514983465,"MED7","mediator complex subunit 7",TRUE
+"204350_s_at",0.990810941805126,0.95380224496051,0.0585920933297758,-5.93801151508002,0.0186048207099976,"MED7","mediator complex subunit 7",TRUE
+"213126_at",0.896345073598643,0.580515094197153,0.560869137078119,-5.78761662336396,0.232950484541975,"MED8","mediator complex subunit 8",TRUE
+"213696_s_at",0.969565920795977,0.85470760403337,-0.185263762315828,-5.92297999130647,-0.0587360622689452,"MED8","mediator complex subunit 8",TRUE
+"213127_s_at",0.986342822130003,0.935438248264586,0.0819296927179168,-5.93641461065727,0.0291528047892289,"MED8","mediator complex subunit 8",TRUE
+"218372_at",0.979976490833035,0.904417385422787,0.121465281884848,-5.93249999550481,0.0358928373694756,"MED9","mediator complex subunit 9",TRUE
+"227058_at",0.410263142293979,0.0158988637558313,2.61096485198459,-3.07328672730774,1.42417004683948,"MEDAG","mesenteric estrogen dependent adipogenesis",TRUE
+"1565765_x_at",0.856631989847095,0.470758080552437,0.73381130408568,-5.68075935586401,0.500055012937998,"MEDAG","mesenteric estrogen dependent adipogenesis",TRUE
+"242176_at",0.892892804749035,0.566421473066585,0.582031128581807,-5.77601926358698,0.282803051789457,"MEF2A","myocyte enhancer factor 2A",TRUE
+"208328_s_at",0.910165867297668,0.626283824882717,0.493833406335757,-5.82159569245622,0.235414442983261,"MEF2A","myocyte enhancer factor 2A",TRUE
+"214684_at",0.971216837324271,0.862439645745888,0.175295371278313,-5.92472785052269,0.0836659087170588,"MEF2A","myocyte enhancer factor 2A",TRUE
+"212535_at",0.995810723090838,0.979892322140104,0.0254899849487596,-5.93936702163089,0.0103189935036152,"MEF2A","myocyte enhancer factor 2A",TRUE
+"205124_at",0.801892820429336,0.339456010526185,0.976299079144894,-5.48580100674671,0.700229992521802,"MEF2B///BORCS8///BORCS8-MEF2B","myocyte enhancer factor 2B///BLOC-1 related complex subunit 8///BORCS8-MEF2B readthrough",TRUE
+"209199_s_at",0.632949074657601,0.1040795221588,1.6950319785848,-4.62951123473574,2.03192405650442,"MEF2C","myocyte enhancer factor 2C",TRUE
+"207968_s_at",0.795265846168267,0.327388919173394,1.00151898345673,-5.46260281838416,0.895704652354121,"MEF2C","myocyte enhancer factor 2C",TRUE
+"209200_at",0.863408882018863,0.48789207600794,0.705432295426728,-5.70016777058027,0.917927933840581,"MEF2C","myocyte enhancer factor 2C",TRUE
+"233522_at",0.846494752313738,0.444589726702173,-0.778360636356543,-5.6488297068148,-0.500056736261258,"MEF2C-AS1","MEF2C antisense RNA 1",TRUE
+"203003_at",0.833762648920706,0.411417157668396,-0.837204758855377,-5.60394248682883,-0.644119572584678,"MEF2D","myocyte enhancer factor 2D",TRUE
+"225641_at",0.886023097762234,0.548579756624798,0.609212972594358,-5.76051359944981,0.414647834116804,"MEF2D","myocyte enhancer factor 2D",TRUE
+"203004_s_at",0.926713349771642,0.680759304622373,-0.416905150979211,-5.8553798366584,-0.2526947666419,"MEF2D","myocyte enhancer factor 2D",TRUE
+"208262_x_at",0.986342822130003,0.933439525115731,-0.0844723161982271,-5.93620860414117,-0.02468181761928,"MEFV","Mediterranean fever",TRUE
+"226210_s_at",0.680160698079016,0.147390758197709,1.50131885065518,-4.89772147529313,1.05451869855797,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"242246_x_at",0.769429807058463,0.276905267583648,1.11474593657597,-5.35190293811675,0.522028250866946,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"229557_at",0.78969417320323,0.31750783970306,1.02265463105954,-5.44274839928463,0.613268638807341,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"212732_at",0.823074246722209,0.38944546651887,0.877849546687385,-5.57115544518317,0.572800469844539,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"235077_at",0.8288884913487,0.399698146278101,0.858704886305987,-5.58677919718663,0.657282466741094,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"1558144_at",0.852006864319744,0.457324391835594,-0.756489943192928,-5.66472742968871,-0.477132263618187,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"226211_at",0.859064198633089,0.475826248297524,0.725354931002911,-5.68661878740609,0.217403787482318,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"210794_s_at",0.940668681806864,0.734380514826162,-0.343607765791809,-5.88234078296054,-0.215512958230543,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"231529_at",0.984726013444734,0.925050440755035,-0.0951506983604936,-5.93527474089339,-0.0628551839676654,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"227390_at",0.986889306520757,0.939020312372339,0.0773742362265639,-5.93676796525753,0.0373392921444893,"MEG3","maternally expressed 3 (non-protein coding)",TRUE
+"228632_at",0.646750698976317,0.117840688449962,1.62716609748945,-4.7263418725353,0.828102141491342,"MEG9","maternally expressed 9 (non-protein coding)",TRUE
+"232523_at",0.65284137151906,0.121799891838298,-1.60887899675372,-4.751914060424,-1.22411343264573,"MEGF10","multiple EGF like domains 10",TRUE
+"236517_at",0.937113154905832,0.720511874559683,0.362366196684292,-5.87592916993757,0.331991899611189,"MEGF10","multiple EGF like domains 10",TRUE
+"1555343_at",0.966769992359004,0.84541912781211,-0.197264306205202,-5.92074804583212,-0.118427874729126,"MEGF10","multiple EGF like domains 10",TRUE
+"1560334_at",0.841813886364358,0.433929714760906,-0.796963678710992,-5.63497113127978,-0.668828240987996,"MEGF11","multiple EGF like domains 11",TRUE
+"1569879_a_at",0.936645656431844,0.717161355559329,0.366917717818762,-5.87432273591783,0.197968212359686,"MEGF11","multiple EGF like domains 11",TRUE
+"1552439_s_at",0.986889306520757,0.938919302712202,-0.0775026708678366,-5.9367582796116,-0.044780710705739,"MEGF11","multiple EGF like domains 11",TRUE
+"226869_at",0.581128536542197,0.0636325834788031,1.95245581993714,-4.2361157276534,2.4487330109811,"MEGF6","multiple EGF like domains 6",TRUE
+"213942_at",0.767727587789514,0.270024304501145,1.13130284508296,-5.33483175067928,1.46427467006425,"MEGF6","multiple EGF like domains 6",TRUE
+"227327_at",0.897949253801113,0.586235151827333,-0.552354132305433,-5.79216555123152,-0.24195333489032,"MEGF8","multiple EGF like domains 8",TRUE
+"214778_at",0.997608949249317,0.988102924793652,-0.0150805062654481,-5.93957271264602,-0.00568100470010879,"MEGF8","multiple EGF like domains 8",TRUE
+"212830_at",0.842925704010552,0.436795080860118,-0.791935916331111,-5.63874701345914,-0.673131918273857,"MEGF9","multiple EGF like domains 9",TRUE
+"212831_at",0.956960361976289,0.805074789322675,-0.249758966496347,-5.90934629516883,-0.253843838079323,"MEGF9","multiple EGF like domains 9",TRUE
+"1554208_at",0.767965891104819,0.270828232881331,1.12935263411506,-5.33685409730929,0.296251108933419,"MEI1","meiotic double-stranded break formation protein 1",TRUE
+"230011_at",0.787211643646529,0.313037093382263,1.03236893468482,-5.43349730226315,0.620324829609206,"MEI1","meiotic double-stranded break formation protein 1",TRUE
+"1564621_a_at",0.830635993561085,0.404097388267679,0.850587242511189,-5.59330709924452,0.381641861989412,"MEI1","meiotic double-stranded break formation protein 1",TRUE
+"238158_at",0.868714861166452,0.50489442362319,0.677834104946589,-5.71834195329617,0.537120934592171,"MEIG1","meiosis/spermiogenesis associated 1",TRUE
+"237265_at",0.94943075115007,0.771563501154137,-0.29390842400293,-5.89769727427484,-0.20922793480092,"MEIOB///LINC00254","meiosis specific with OB domains///long intergenic non-protein coding RNA 254",TRUE
+"1562484_at",0.366569797255916,0.0108479182800196,2.78111266053585,-2.74420691109417,4.03649354830484,"MEIOC","meiosis specific with coiled-coil domain",TRUE
+"1566478_at",0.610455440146151,0.0831048849242681,1.81487945052801,-4.45133591934512,1.03785664082473,"MEIOC","meiosis specific with coiled-coil domain",TRUE
+"1566480_x_at",0.657015752622694,0.125825472685346,1.59078758952762,-4.77699190025179,0.479446483036828,"MEIOC","meiosis specific with coiled-coil domain",TRUE
+"1557206_at",0.740610299769501,0.230561867412264,1.23282558218323,-5.22534614977319,1.34568291191963,"MEIOC","meiosis specific with coiled-coil domain",TRUE
+"1564075_a_at",0.945498722604777,0.754386721522038,-0.316765630903572,-5.89092916338913,-0.231053334487348,"MEIOC","meiosis specific with coiled-coil domain",TRUE
+"1559477_s_at",0.700061364939874,0.171362642160647,1.41364609446308,-5.01056341187661,1.38198757008561,"MEIS1","Meis homeobox 1",TRUE
+"204069_at",0.875938621758472,0.524268738777129,0.647015938440978,-5.73781586077793,0.365219360213255,"MEIS1","Meis homeobox 1",TRUE
+"207480_s_at",0.637485146909712,0.108769418600396,1.67109431137449,-4.66400882355136,2.20459195952141,"MEIS2","Meis homeobox 2",TRUE
+"1569402_at",0.729083413548563,0.211044152892304,-1.28797534832506,-5.16247217367839,-0.94034227406409,"MEIS3","Meis homeobox 3",TRUE
+"228327_x_at",0.906476756086155,0.613336453282751,-0.51255241368075,-5.81253087915578,-0.413130369075112,"MEIS3","Meis homeobox 3",TRUE
+"214077_x_at",0.635916735157933,0.107092600411394,1.67955072964604,-4.65186432131305,0.96510167545582,"MEIS3P1","Meis homeobox 3 pseudogene 1",TRUE
+"204825_at",0.913233126230689,0.636135354525829,0.479709531054516,-5.82821721838966,0.145183195442893,"MELK","maternal embryonic leucine zipper kinase",TRUE
+"220043_s_at",0.153726668922469,0.00115512504738241,3.72878912660034,-0.783726030456014,2.97466718053242,"MELTF","melanotransferrin",TRUE
+"235911_at",0.15849596124168,0.00124071826998517,3.69933512318425,-0.846736275443,2.99139426501469,"MELTF","melanotransferrin",TRUE
+"223723_at",0.402463840838386,0.0147903334829911,2.64341743836419,-3.01127336768252,3.14415794128382,"MELTF","melanotransferrin",TRUE
+"1556538_at",0.829519289742569,0.400897748407268,0.856485675885496,-5.58856953912006,0.358777006734068,"MELTF","melanotransferrin",TRUE
+"202645_s_at",0.539114280228505,0.0441741536174,-2.13377804155573,-3.93636632831324,-0.782693773894151,"MEN1","menin 1",TRUE
+"205619_s_at",0.99739139970986,0.986814144054179,-0.0167142914502983,-5.93954741203723,-0.014934825841296,"MEOX1","mesenchyme homeobox 1",TRUE
+"206201_s_at",0.961212424803935,0.823974487036355,-0.225087165751981,-5.91503688504207,-0.245954871842662,"MEOX2","mesenchyme homeobox 2",TRUE
+"206202_at",0.969126309864506,0.853853854323235,0.18636560311135,-5.92278088184027,0.117246083883815,"MEOX2","mesenchyme homeobox 2",TRUE
+"206000_at",0.808811461484454,0.352014847371756,0.950695805192648,-5.50879945315763,0.517787824671235,"MEP1A","meprin A subunit alpha",TRUE
+"207251_at",0.775121983908223,0.291555002733118,1.08046751307622,-5.38653526029106,0.591823877207115,"MEP1B","meprin A subunit beta",TRUE
+"219798_s_at",0.789378278298554,0.315830078081862,-1.02628884589447,-5.43929671774297,-0.377544508749979,"MEPCE","methylphosphate capping enzyme",TRUE
+"221150_at",0.715994230654393,0.191691331473599,1.34670141002132,-5.09295778088244,1.12163269759219,"MEPE","matrix extracellular phosphoglycoprotein",TRUE
+"211913_s_at",0.822850703882235,0.388491299106924,-0.87964778499427,-5.5696714858308,-0.585082237472208,"MERTK","MER proto-oncogene, tyrosine kinase",TRUE
+"211912_at",0.854810562588402,0.466834662323043,0.740394568151335,-5.67615318114762,0.3911593589848,"MERTK","MER proto-oncogene, tyrosine kinase",TRUE
+"206028_s_at",0.954456115752166,0.791244814933857,-0.267912755234868,-5.90478377443656,-0.264444232008888,"MERTK","MER proto-oncogene, tyrosine kinase",TRUE
+"1556321_a_at",0.908033019585207,0.61853129067375,0.505019913856461,-5.81621810929723,0.20574844153747,"MESDC1","mesoderm development candidate 1",TRUE
+"223264_at",0.949179181265614,0.770565630203668,-0.295231811615029,-5.89731911219555,-0.107019821975481,"MESDC1","mesoderm development candidate 1",TRUE
+"239746_at",0.585036027492332,0.0651430114096649,-1.9405477189932,-4.25517638130642,-0.79828579529114,"MESDC2","mesoderm development candidate 2",TRUE
+"224672_x_at",0.724970327905974,0.202798683280528,-1.31246052465068,-5.13380709427948,-1.12720659067704,"MESDC2","mesoderm development candidate 2",TRUE
+"224679_at",0.951810226174863,0.779021203595934,0.284034704796796,-5.90046552708133,0.107208277203005,"MESDC2","mesoderm development candidate 2",TRUE
+"238679_at",0.955203530479627,0.79512993862764,-0.262803953961689,-5.9060998933134,-0.094440695965214,"MESDC2","mesoderm development candidate 2",TRUE
+"224675_at",0.999016635322945,0.996839126362192,-0.00400651579536193,-5.93967566233253,-0.00142976602434786,"MESDC2","mesoderm development candidate 2",TRUE
+"224476_s_at",0.547793752989355,0.0482421024268547,2.09065387507649,-4.0092272183834,2.21585013884946,"MESP1","mesoderm posterior bHLH transcription factor 1",TRUE
+"243387_at",0.629142935083042,0.100087521707404,1.71613996936425,-4.59878549103974,1.17594556814348,"MESP1","mesoderm posterior bHLH transcription factor 1",TRUE
+"229195_at",0.847093798440272,0.445800413882617,0.77626517632908,-5.65037141447216,0.378044228562605,"MESP1","mesoderm posterior bHLH transcription factor 1",TRUE
+"1556015_a_at",0.523369751179323,0.0388234249675315,2.19631747272056,-3.82904600740918,0.618795210196355,"MESP2","mesoderm posterior bHLH transcription factor 2",TRUE
+"1556014_at",0.774230543658252,0.287038067604411,1.09090112572801,-5.376095850665,0.47645000670203,"MESP2","mesoderm posterior bHLH transcription factor 2",TRUE
+"202016_at",0.956312775124107,0.801896482999485,0.253923131362026,-5.90832783569577,0.31886054762267,"MEST","mesoderm specific transcript",TRUE
+"211599_x_at",0.156242460469172,0.00119103341004181,3.71617885892534,-0.810712124671368,2.95012770623651,"MET","MET proto-oncogene, receptor tyrosine kinase",TRUE
+"213807_x_at",0.171789627700233,0.0014955987706504,3.62219905352972,-1.01136870939087,2.99938977679352,"MET","MET proto-oncogene, receptor tyrosine kinase",TRUE
+"213816_s_at",0.250356179889913,0.00351406953505576,3.26586427494046,-1.76227389731195,4.0342447120581,"MET","MET proto-oncogene, receptor tyrosine kinase",TRUE
+"203510_at",0.499265335405817,0.0314310574351487,2.29705116837424,-3.65224001509241,4.06848770577645,"MET","MET proto-oncogene, receptor tyrosine kinase",TRUE
+"212673_at",0.899808883319249,0.592796672573957,0.542637046660409,-5.79727408675403,0.15844752195135,"METAP1","methionyl aminopeptidase 1",TRUE
+"1565755_at",0.623667408398064,0.0947950548079839,-1.74525940746934,-4.55593275968624,-1.46852445835113,"METAP1D","methionyl aminopeptidase type 1D (mitochondrial)",TRUE
+"227805_at",0.819203514175924,0.375957622005937,-0.903541707312856,-5.54968660612618,-0.472846535111017,"METAP1D","methionyl aminopeptidase type 1D (mitochondrial)",TRUE
+"1565756_a_at",0.865148641923909,0.494266897134792,0.695021341913503,-5.7071049929414,0.396072256868863,"METAP1D","methionyl aminopeptidase type 1D (mitochondrial)",TRUE
+"1569029_at",0.880749245460109,0.536278429457933,0.628225990343992,-5.7492621269074,0.396930459974554,"METAP1D","methionyl aminopeptidase type 1D (mitochondrial)",TRUE
+"213899_at",0.756952614607938,0.252521771038321,-1.17486281845196,-5.28886135084692,-0.414615810296036,"METAP2","methionyl aminopeptidase 2",TRUE
+"227993_at",0.84899624366548,0.449625738878128,-0.769666952570266,-5.65520035215863,-0.269678566928809,"METAP2","methionyl aminopeptidase 2",TRUE
+"202015_x_at",0.884024105338928,0.542654175096207,0.61834291828189,-5.75515229018065,0.359537094692524,"METAP2","methionyl aminopeptidase 2",TRUE
+"209861_s_at",0.95877806139143,0.813186976455327,-0.239150754857912,-5.91186516780078,-0.0680074180153039,"METAP2","methionyl aminopeptidase 2",TRUE
+"232269_x_at",0.769258076576208,0.276094586321714,-1.11668087056038,-5.34991939931874,-0.920892340895945,"METRN","meteorin, glial cell differentiation regulator",TRUE
+"219051_x_at",0.771011793494937,0.279832036998645,-1.10779445092649,-5.35900387719287,-0.825712197031473,"METRN","meteorin, glial cell differentiation regulator",TRUE
+"228419_at",0.925511384407886,0.678202689144372,-0.420455327496458,-5.85394404364359,-0.260159533938951,"METRN","meteorin, glial cell differentiation regulator",TRUE
+"225955_at",0.959451355429682,0.816865013825302,0.234350330871127,-5.91296928154389,0.208005653123005,"METRNL","meteorin like, glial cell differentiation regulator",TRUE
+"204027_s_at",0.624374299616567,0.095920511170514,-1.73895283407154,-4.56525905828096,-0.717345184850984,"METTL1","methyltransferase like 1",TRUE
+"226631_at",0.734913444725244,0.219945422558442,1.26235897569428,-5.19196933554894,0.504044486737627,"METTL10","methyltransferase like 10",TRUE
+"215061_at",0.9181984176728,0.652747057835841,-0.45611426243398,-5.83885961791062,-0.147146803786177,"METTL10","methyltransferase like 10",TRUE
+"226634_at",0.999500506744552,0.99853162650939,-0.00186120970275215,-5.9396817935131,-0.00077272721220023,"METTL10","methyltransferase like 10",TRUE
+"238680_at",0.729789891627758,0.212191170836198,-1.28462823298601,-5.16635505042447,-1.1303244238324,"METTL12///SNORA57","methyltransferase like 12///small nucleolar RNA, H/ACA box 57",TRUE
+"239316_at",0.989524702314661,0.94891021225155,-0.0648052519764196,-5.93763815864996,-0.0248044974118162,"METTL12///SNORA57","methyltransferase like 12///small nucleolar RNA, H/ACA box 57",TRUE
+"206468_s_at",0.571833476034523,0.059911200543902,-1.98289613036192,-4.18703102655322,-0.630034460227858,"METTL13","methyltransferase like 13",TRUE
+"212405_s_at",0.585036027492332,0.0656536607848647,-1.93657681719373,-4.26151459771033,-0.557615822233567,"METTL13","methyltransferase like 13",TRUE
+"212407_at",0.630132423960255,0.101289100910523,-1.70971230882229,-4.60817207126742,-0.520628542995388,"METTL13","methyltransferase like 13",TRUE
+"236060_at",0.424084762414675,0.0179240494938682,-2.55681022279497,-3.17592945483149,-1.76778063106179,"METTL14","methyltransferase like 14",TRUE
+"241689_at",0.636147339487472,0.107403744370507,-1.67797316496808,-4.65413343116132,-0.583395823516627,"METTL14","methyltransferase like 14",TRUE
+"227601_at",0.899808883319249,0.593043198762469,-0.542272994958926,-5.79746376634796,-0.143259231391907,"METTL14","methyltransferase like 14",TRUE
+"235552_at",0.913140067375992,0.635382615518578,0.480785191146336,-5.82771953755457,0.124626537535205,"METTL14","methyltransferase like 14",TRUE
+"1567590_at",0.708222957155366,0.180115961943216,1.38408737432489,-5.04735257305556,1.07539237276664,"METTL15","methyltransferase like 15",TRUE
+"242247_at",0.778800606399021,0.29975237247823,-1.06182505675839,-5.40496478071349,-0.390538327897803,"METTL15","methyltransferase like 15",TRUE
+"1567591_at",0.790439917087227,0.320166116210585,-1.01692395450791,-5.44816876105838,-0.658580372639897,"METTL15","methyltransferase like 15",TRUE
+"238773_at",0.813488170855271,0.364101102920669,-0.926633411678552,-5.52990294540642,-0.278083728594385,"METTL15","methyltransferase like 15",TRUE
+"1565900_at",0.873230718105642,0.517809849752989,0.657218610983396,-5.73146500876205,0.430589379941032,"METTL15","methyltransferase like 15",TRUE
+"1565898_at",0.885694554133555,0.547487682547966,0.610891664001895,-5.7595336048265,0.340377927659332,"METTL15","methyltransferase like 15",TRUE
+"1562830_at",0.956762870061999,0.804248830449059,0.250840687257321,-5.90908334026643,0.0605988143920166,"METTL15","methyltransferase like 15",TRUE
+"223988_x_at",0.667209925683767,0.133735875150752,1.55659637325269,-4.82378088854158,0.621372928441414,"METTL17","methyltransferase like 17",TRUE
+"218366_x_at",0.695744345349551,0.165404071607254,1.43446551015583,-4.9842678482979,0.593140274767292,"METTL17","methyltransferase like 17",TRUE
+"223528_s_at",0.725181883744124,0.203718772497948,1.30969039121714,-5.13707305658035,0.68121985058487,"METTL17","methyltransferase like 17",TRUE
+"1558590_at",0.877546037473893,0.528071485192668,-0.641041215842151,-5.74149063944648,-0.378405320352457,"METTL17","methyltransferase like 17",TRUE
+"213528_at",0.727294834785485,0.207686406136365,-1.29785514768614,-5.15096087685484,-0.512084415304736,"METTL18","methyltransferase like 18",TRUE
+"1553743_at",0.686747966354964,0.155297247438642,-1.47120273525661,-4.93710373218427,-0.852640959290112,"METTL21A","methyltransferase like 21A",TRUE
+"235931_at",0.864726282448413,0.492129105354255,0.698504013132269,-5.7047953042366,0.339554607626372,"METTL21A","methyltransferase like 21A",TRUE
+"235177_at",0.86481525165637,0.492431017854236,0.698011643503668,-5.70512250962336,0.336876097616443,"METTL21A","methyltransferase like 21A",TRUE
+"213861_s_at",0.774230543658252,0.288005893399407,-1.08865565500448,-5.37835012201639,-0.37441322053026,"METTL21B","methyltransferase like 21B",TRUE
+"230331_at",0.937203701144735,0.721089453712954,0.361582373035039,-5.87620381780079,0.204766903945032,"METTL21C","methyltransferase like 21C",TRUE
+"1560646_at",0.816941414563225,0.369136491024864,0.916766383967755,-5.5384127685469,0.459166189363552,"METTL21EP","methyltransferase like 21E, pseudogene",TRUE
+"218945_at",0.695744345349551,0.165544258014507,-1.43396883113572,-4.98489883448027,-0.404271384742501,"METTL22","methyltransferase like 22",TRUE
+"233742_at",0.95442332217412,0.790379279245846,0.26905189228182,-5.90448688117404,0.232556990385829,"METTL22","methyltransferase like 22",TRUE
+"225808_at",0.990984475090957,0.957884512619061,-0.0534092012356994,-5.93829420783812,-0.0176770315834656,"METTL23","methyltransferase like 23",TRUE
+"229018_at",0.872668627020452,0.516203457700879,0.659767007491904,-5.72986383270799,0.37732550414725,"METTL25","methyltransferase like 25",TRUE
+"227378_x_at",0.854184492233394,0.464487148233895,-0.744349246439089,-5.67336741703151,-0.243051378084539,"METTL26","methyltransferase like 26",TRUE
+"1554466_a_at",0.895213601869362,0.573072872603617,0.572010993276463,-5.78156244619724,0.26988660376225,"METTL26","methyltransferase like 26",TRUE
+"227380_x_at",0.913468969775679,0.637147307241432,0.478264359850825,-5.82888414632517,0.177688465989492,"METTL26","methyltransferase like 26",TRUE
+"230851_x_at",0.916790160854655,0.648348598052947,-0.462335743944749,-5.83610450372459,-0.236032980189168,"METTL26","methyltransferase like 26",TRUE
+"228118_x_at",0.973071267819624,0.870533618530565,0.164879790345964,-5.92645116915258,0.0876359930202382,"METTL26","methyltransferase like 26",TRUE
+"228114_x_at",0.989586772349659,0.949241884379063,-0.0643839297875764,-5.93766466429645,-0.0220362063456303,"METTL26","methyltransferase like 26",TRUE
+"225253_s_at",0.949347776420105,0.77118120058386,-0.294415371840981,-5.89755261145108,-0.103155237191899,"METTL2A///METTL2B","methyltransferase like 2A///methyltransferase like 2B",TRUE
+"221079_s_at",0.960948036997835,0.822205946388582,0.227389542012648,-5.91453072540923,0.073456905478757,"METTL2A///METTL2B","methyltransferase like 2A///methyltransferase like 2B",TRUE
+"222276_at",0.954577684533304,0.792263254003882,0.26657284458149,-5.90513139413352,0.0827629466202069,"METTL2B","methyltransferase like 2B",TRUE
+"209265_s_at",0.833125357773815,0.410346786641593,-0.839152170970342,-5.60240462135653,-0.287546783609045,"METTL3","methyltransferase like 3",TRUE
+"213653_at",0.871744769522775,0.513787256206841,-0.66360838904862,-5.72743903883405,-0.20860732961393,"METTL3","methyltransferase like 3",TRUE
+"242111_at",0.952697366942815,0.783696045447366,-0.277860122721457,-5.9021489691667,-0.0958380050099201,"METTL3","methyltransferase like 3",TRUE
+"219698_s_at",0.635916735157933,0.107132602949393,1.67934769129172,-4.65215645458339,0.668959961157197,"METTL4","methyltransferase like 4",TRUE
+"232194_at",0.823518986434235,0.390422458844334,0.876011258121212,-5.57266954185077,0.434398296963177,"METTL4","methyltransferase like 4",TRUE
+"221570_s_at",0.863993702749895,0.490617055553644,-0.700972528725535,-5.70315152910826,-0.196280747838991,"METTL5","methyltransferase like 5",TRUE
+"220839_at",0.989669132517581,0.950474315518251,-0.0628184799175209,-5.93776163377919,-0.0334653223363208,"METTL5","methyltransferase like 5",TRUE
+"232102_at",0.702809964629668,0.174489646901567,-1.40295127846354,-5.02394838906699,-1.0159307693263,"METTL6","methyltransferase like 6",TRUE
+"1553689_s_at",0.722183254960573,0.198433635834891,-1.32573752134957,-5.11807278640125,-0.40940732986358,"METTL6","methyltransferase like 6",TRUE
+"1553688_at",0.957243533506016,0.806499133360867,-0.247894282368507,-5.90979692819714,-0.110392177643329,"METTL6","methyltransferase like 6",TRUE
+"1557991_at",0.961690794738111,0.826362807806277,0.221979899123783,-5.91571186606981,0.152550854687556,"METTL6","methyltransferase like 6",TRUE
+"233581_at",0.999912712295067,0.999802982504966,-0.000249725739693258,-5.93968345037442,-0.000169921807469997,"METTL6","methyltransferase like 6",TRUE
+"209703_x_at",0.766086095192912,0.266491325444406,-1.13992417308168,-5.32585464757973,-0.840952705589476,"METTL7A","methyltransferase like 7A",TRUE
+"211424_x_at",0.812896635201594,0.361893988870224,0.930987057561438,-5.52612148696867,0.450740091753433,"METTL7A","methyltransferase like 7A",TRUE
+"207761_s_at",0.914875873723275,0.641375258158448,-0.472237533939194,-5.83164422401548,-0.553132005101471,"METTL7A","methyltransferase like 7A",TRUE
+"244376_at",0.960031906173606,0.819143591301938,0.231379253914249,-5.91364148253717,0.112597259599752,"METTL7A","methyltransferase like 7A",TRUE
+"227055_at",0.677013732819214,0.143816585134912,-1.51536750800002,-4.8791314459893,-0.78824784083273,"METTL7B","methyltransferase like 7B",TRUE
+"220007_at",0.7994347047598,0.334616904701311,-0.986337256261193,-5.47663200140887,-0.312803495674007,"METTL8","methyltransferase like 8",TRUE
+"1554667_s_at",0.904726051304548,0.609190481550561,-0.518585667997086,-5.80953916188099,-0.184863514554472,"METTL8","methyltransferase like 8",TRUE
+"232533_at",0.909052380289506,0.622056354280406,-0.499925417116875,-5.81868171908608,-0.27556267867455,"METTL8","methyltransferase like 8",TRUE
+"217868_s_at",0.61760967235709,0.0882951549874167,-1.78299144715913,-4.49961506617626,-0.57328592619308,"METTL9","methyltransferase like 9",TRUE
+"226220_at",0.720021194788968,0.196127139344007,1.33284543842036,-5.1095945119097,0.421597541315073,"METTL9","methyltransferase like 9",TRUE
+"230395_at",0.846015118644589,0.443945973707487,-0.779476262408853,-5.64800730051155,-0.712383715905612,"METTL9","methyltransferase like 9",TRUE
+"222447_at",0.853460708803218,0.462146280408814,-0.74830458323821,-5.67056712189276,-0.282736482368431,"METTL9","methyltransferase like 9",TRUE
+"236885_at",0.837609393049242,0.422005465149163,-0.818110841622596,-5.61884379673812,-0.629717044718856,"MEX3A","mex-3 RNA binding family member A",TRUE
+"226346_at",0.874623344533688,0.521116547101514,-0.6519865484646,-5.73473372025564,-0.345209583967977,"MEX3A","mex-3 RNA binding family member A",TRUE
+"227512_at",0.956762870061999,0.804167679796511,-0.250946983059105,-5.90905743992729,-0.121251869345063,"MEX3A","mex-3 RNA binding family member A",TRUE
+"223627_at",0.525405708458677,0.039326721469268,-2.19011288438062,-3.83977910477971,-1.97044812099663,"MEX3B","mex-3 RNA binding family member B",TRUE
+"227275_at",0.515810181619652,0.0361944520381564,2.22996557429388,-3.77051714682173,0.916711465304823,"MEX3C","mex-3 RNA binding family member C",TRUE
+"1556874_a_at",0.547740112248337,0.0480468509985006,2.0926476447681,-4.00587962755775,0.661173879081547,"MEX3C","mex-3 RNA binding family member C",TRUE
+"222567_s_at",0.928295253101366,0.685216375700252,-0.410728930512326,-5.85784914079635,-0.164512692759622,"MEX3C","mex-3 RNA binding family member C",TRUE
+"1556873_at",0.954096423385239,0.789357615772817,0.270396978414355,-5.904134700839,0.31565239752489,"MEX3C","mex-3 RNA binding family member C",TRUE
+"218247_s_at",0.975398143273847,0.881967155250875,0.150198223159926,-5.92870154678665,0.051965037286692,"MEX3C","mex-3 RNA binding family member C",TRUE
+"244712_at",0.609045683857105,0.0815179938631238,1.82497285513319,-4.43592550798922,0.593952202598063,"MEX3D","mex-3 RNA binding family member D",TRUE
+"91816_f_at",0.737161440695888,0.22333360009899,-1.25281747539151,-5.20282673742457,-0.600044605264738,"MEX3D","mex-3 RNA binding family member D",TRUE
+"222042_x_at",0.746535697909741,0.238430337524717,1.21159706647285,-5.24891613569794,0.56618001809264,"MEX3D","mex-3 RNA binding family member D",TRUE
+"203406_at",0.979134448263299,0.898708425270149,-0.128760994794753,-5.93161149419619,-0.034196513780719,"MFAP1","microfibrillar associated protein 1",TRUE
+"203417_at",0.300116716920836,0.00563248112610727,3.06552182829481,-2.17491136232293,3.74279604213229,"MFAP2","microfibrillar associated protein 2",TRUE
+"213123_at",0.661121988136487,0.128841312945105,-1.57754727779314,-4.79520509792494,-0.461702073734672,"MFAP3","microfibrillar associated protein 3",TRUE
+"214588_s_at",0.768852835478002,0.274168213385238,-1.12129541149986,-5.34517664852492,-0.390431484128968,"MFAP3","microfibrillar associated protein 3",TRUE
+"1552312_a_at",0.789795896476304,0.317845967292542,-1.0219238404658,-5.4434411491876,-0.335902274774394,"MFAP3","microfibrillar associated protein 3",TRUE
+"210843_s_at",0.602351341567358,0.077179307091775,-1.85346601213742,-4.39209272715461,-1.51717959733874,"MFAP3L","microfibrillar associated protein 3 like",TRUE
+"210492_at",0.687734660055697,0.156952815460246,-1.46505501411176,-4.94506377385248,-1.24704476996269,"MFAP3L","microfibrillar associated protein 3 like",TRUE
+"205442_at",0.69114521567028,0.160822758077264,-1.45088674069174,-4.96330578390472,-2.12898838421124,"MFAP3L","microfibrillar associated protein 3 like",TRUE
+"210493_s_at",0.896118635245982,0.57840329851468,-0.564023391976365,-5.78591440555042,-0.306102120728995,"MFAP3L","microfibrillar associated protein 3 like",TRUE
+"1569300_at",0.955816406528307,0.79862664530396,-0.258212013871255,-5.90726137898297,-0.213310517011494,"MFAP3L","microfibrillar associated protein 3 like",TRUE
+"212713_at",0.931582451098271,0.69834281969479,0.392632398242496,-5.86487539639267,0.133821345519398,"MFAP4","microfibrillar associated protein 4",TRUE
+"213764_s_at",0.0681210092794308,0.000174157134490097,4.50242442548751,0.884327334020901,6.97606773382367,"MFAP5","microfibrillar associated protein 5",TRUE
+"209758_s_at",0.0723378272955723,0.000227039311563208,4.39424192698496,0.650870091647727,3.84857921954053,"MFAP5","microfibrillar associated protein 5",TRUE
+"213765_at",0.189245182004241,0.00188775797985474,3.5257153782176,-1.21640278753065,4.33191154686883,"MFAP5","microfibrillar associated protein 5",TRUE
+"219137_s_at",0.655745626967443,0.124266780190821,-1.59773446530116,-4.76738840093307,-0.588498114684542,"MFF","mitochondrial fission factor",TRUE
+"223091_x_at",0.695744345349551,0.165243120100739,-1.43503617734546,-4.98354264625117,-0.606771168470333,"MFF","mitochondrial fission factor",TRUE
+"222832_s_at",0.730101539866086,0.212909623403034,-1.28253882508705,-5.16877454211851,-0.40580378030578,"MFF","mitochondrial fission factor",TRUE
+"223354_x_at",0.774230543658252,0.287361391200081,-1.09015037008581,-5.3768500092464,-0.405299093677854,"MFF","mitochondrial fission factor",TRUE
+"1558960_a_at",0.72050514215489,0.196484021491123,-1.33174137456119,-5.11091393350541,-0.587066254838172,"MFGE8","milk fat globule-EGF factor 8 protein",TRUE
+"210605_s_at",0.737161440695888,0.22332974823158,1.25282825959787,-5.20281450580898,1.06521667043858,"MFGE8","milk fat globule-EGF factor 8 protein",TRUE
+"225478_at",0.764418318577934,0.264411142952828,1.14503968925467,-5.32049964066814,0.524558906236123,"MFHAS1","malignant fibrous histiocytoma amplified sequence 1",TRUE
+"213457_at",0.797963285726587,0.332081119750287,0.991637399563769,-5.4717563527683,0.512856616827296,"MFHAS1","malignant fibrous histiocytoma amplified sequence 1",TRUE
+"242087_x_at",0.820536502908875,0.380800973476174,-0.894247411751575,-5.55751927113841,-0.408827301486349,"MFI2-AS1","MFI2 antisense RNA 1",TRUE
+"239521_at",0.880581893984565,0.535999367751373,0.628660000770359,-5.74900140191417,0.508870089561565,"MFI2-AS1","MFI2 antisense RNA 1",TRUE
+"243629_x_at",0.990984475090957,0.957837896818245,0.0534683764328775,-5.93829112783045,0.024244376730878,"MFI2-AS1","MFI2 antisense RNA 1",TRUE
+"217043_s_at",0.726535590042475,0.205605286921819,1.30404090599975,-5.14371564920404,0.415247549105658,"MFN1","mitofusin 1",TRUE
+"211801_x_at",0.767704684098492,0.269545404546749,1.13246660868923,-5.33362347327044,0.323089481460762,"MFN1","mitofusin 1",TRUE
+"207098_s_at",0.786455312223125,0.312101620284197,1.03441390697063,-5.43153978896887,0.300942392742035,"MFN1","mitofusin 1",TRUE
+"216205_s_at",0.723655063748891,0.200431838791865,1.31963168309929,-5.12532528982273,0.428442191532545,"MFN2","mitofusin 2",TRUE
+"201155_s_at",0.813065886130395,0.362453590626918,0.929881536738849,-5.52708325643704,0.36894253739194,"MFN2","mitofusin 2",TRUE
+"1566105_at",0.898407712535128,0.587759635136308,0.550091729035226,-5.79336282335119,0.327899490711441,"MFN2","mitofusin 2",TRUE
+"204153_s_at",0.580630437263151,0.0629516185447301,1.95790625044181,-4.2273649301963,0.818181961405241,"MFNG","MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase",TRUE
+"204152_s_at",0.715549750539287,0.191284410679144,1.34798505715179,-5.09140921823266,1.07361468165,"MFNG","MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase",TRUE
+"213783_at",0.766550448794594,0.267709865735944,-1.13694120790979,-5.32896751124322,-0.696065303233135,"MFNG","MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase",TRUE
+"218109_s_at",0.837201352670384,0.419726132200236,0.822195461386711,-5.61568313144474,0.355365853886408,"MFSD1","major facilitator superfamily domain containing 1",TRUE
+"209215_at",0.864175199827872,0.491445422093327,-0.699619628741558,-5.70405310501084,-0.354473988849337,"MFSD10","major facilitator superfamily domain containing 10",TRUE
+"221192_x_at",0.989638901366417,0.950016257973009,0.0634002915004342,-5.93772587289877,0.0218221994592316,"MFSD11","major facilitator superfamily domain containing 11",TRUE
+"223242_s_at",0.993881123128578,0.971067756699198,0.0366811036389505,-5.93902815691771,0.0139433080180567,"MFSD11","major facilitator superfamily domain containing 11",TRUE
+"226516_at",0.839519981963042,0.427497114460865,-0.808326050577556,-5.62635519672087,-0.2226620628985,"MFSD12","major facilitator superfamily domain containing 12",TRUE
+"220178_at",0.902591244881539,0.601779800977661,-0.529418701252308,-5.80408179168073,-0.249701318637861,"MFSD12","major facilitator superfamily domain containing 12",TRUE
+"219745_at",0.69887421412603,0.170182758452725,1.4177220393165,-5.00544020432399,0.796637342941631,"MFSD13A","major facilitator superfamily domain containing 13A",TRUE
+"225222_at",0.920780424288498,0.663056908372443,-0.441602128193917,-5.84514389282923,-0.140553972931555,"MFSD14A","major facilitator superfamily domain containing 14A",TRUE
+"233954_at",0.654592482818544,0.123519536264086,-1.60109061191074,-4.76273713487633,-1.16165072329793,"MFSD14B","major facilitator superfamily domain containing 14B",TRUE
+"223073_at",0.866365799176078,0.497287732985461,0.690114750361873,-5.71034031809945,0.199454670223441,"MFSD14B","major facilitator superfamily domain containing 14B",TRUE
+"224078_at",0.982909728377256,0.91696479930812,0.105453555218993,-5.93426856952125,0.0414570939090222,"MFSD14C","major facilitator superfamily domain containing 14C",TRUE
+"225316_at",0.819193107051406,0.375705440660247,-0.904027793357841,-5.54927490267261,-0.829111713110678,"MFSD2A","major facilitator superfamily domain containing 2A",TRUE
+"1553386_at",0.854634579618861,0.466403046852631,0.741120790596347,-5.67564266847287,0.421908851060331,"MFSD2A","major facilitator superfamily domain containing 2A",TRUE
+"209931_s_at",0.412437259854273,0.016459773223631,2.59534591481633,-3.10299962300815,1.11534359051274,"MFSD2B///FKBP1B","major facilitator superfamily domain containing 2B///FK506 binding protein 1B",TRUE
+"227296_at",0.950629206489271,0.774984509287183,0.289375493550197,-5.89897980267054,0.221221862048298,"MFSD3","major facilitator superfamily domain containing 3",TRUE
+"239304_at",0.617775129514679,0.0885821785600243,1.78127566238361,-4.50219514656031,0.955647170662301,"MFSD4A","major facilitator superfamily domain containing 4A",TRUE
+"242372_s_at",0.680160698079016,0.147418191971164,1.50121210177028,-4.89786220109695,0.382634271412467,"MFSD4A","major facilitator superfamily domain containing 4A",TRUE
+"229254_at",0.972899347107693,0.868662297413245,-0.167286164011241,-5.92606236906813,-0.16585854231973,"MFSD4A","major facilitator superfamily domain containing 4A",TRUE
+"238862_at",0.990739624391638,0.953121417528592,0.059456635468359,-5.93796181468833,0.0332705226479471,"MFSD4A","major facilitator superfamily domain containing 4A",TRUE
+"242851_at",0.854184492233394,0.464717595677023,-0.743960504308264,-5.67364187918055,-0.377020629595475,"MFSD4B","major facilitator superfamily domain containing 4B",TRUE
+"238828_at",0.991689960875868,0.961215546638656,-0.0491812007893626,-5.93850544573929,-0.0186499915147103,"MFSD4B","major facilitator superfamily domain containing 4B",TRUE
+"232139_s_at",0.996261754016157,0.981810227395309,-0.0230582317569894,-5.93942452134261,-0.00986048467130018,"MFSD4B","major facilitator superfamily domain containing 4B",TRUE
+"212861_at",0.737161440695888,0.223325321858788,-1.25284065244242,-5.20280044953922,-0.483694661633132,"MFSD5","major facilitator superfamily domain containing 5",TRUE
+"219858_s_at",0.924696623416105,0.674373171688958,-0.42578340047954,-5.85176676119191,-0.22177486718633,"MFSD6","major facilitator superfamily domain containing 6",TRUE
+"225325_at",0.984132887597385,0.92206978952102,-0.0989474046284327,-5.93491597069912,-0.0419734421644371,"MFSD6","major facilitator superfamily domain containing 6",TRUE
+"1552432_at",0.868397087637799,0.50429289067369,0.678801425760614,-5.71771666491692,0.260487308035609,"MFSD6L","major facilitator superfamily domain containing 6 like",TRUE
+"205144_at",0.845574460920178,0.442900071546997,0.781290921704538,-5.64666721538149,0.227697159652618,"MFSD7","major facilitator superfamily domain containing 7",TRUE
+"214269_at",0.916392138713508,0.646945814370071,-0.464323827570382,-5.83521639374784,-0.486004335878763,"MFSD7","major facilitator superfamily domain containing 7",TRUE
+"228282_at",0.874406257596174,0.520383047219872,-0.653145554097144,-5.73401179732083,-0.232192172864842,"MFSD8","major facilitator superfamily domain containing 8",TRUE
+"229509_at",0.952695930395225,0.783362614408379,0.27830015397747,-5.9020302139465,0.0755711477385006,"MFSD8","major facilitator superfamily domain containing 8",TRUE
+"243407_at",0.961778365989609,0.826695941176004,-0.221546662329186,-5.91580523488574,-0.0590399283387049,"MFSD8","major facilitator superfamily domain containing 8",TRUE
+"224483_s_at",0.677013732819214,0.144008607082444,1.51460552246717,-4.88014330025569,1.50168192460456,"MFSD9","major facilitator superfamily domain containing 9",TRUE
+"213403_at",0.909748582642183,0.624656321709812,-0.496176470389547,-5.8204790701872,-0.15999717649255,"MFSD9","major facilitator superfamily domain containing 9",TRUE
+"213393_at",0.93089781226267,0.693917315065395,0.398718337967299,-5.86254722271956,0.116996371359964,"MFSD9","major facilitator superfamily domain containing 9",TRUE
+"235409_at",0.567651250567208,0.0577726960987955,2.00115496315145,-4.15734302891183,0.653357896724085,"MGA","MGA, MAX dimerization protein",TRUE
+"212945_s_at",0.687734660055697,0.157069317645841,1.46462438208248,-4.94562034246831,0.566328235085962,"MGA","MGA, MAX dimerization protein",TRUE
+"1564640_at",0.742286839825305,0.232671456075465,1.22708089757724,-5.2317593740506,1.29434883313349,"MGA","MGA, MAX dimerization protein",TRUE
+"230848_s_at",0.940938843113333,0.735395910730207,0.342239370262223,-5.88279531943785,0.190083722137084,"MGA","MGA, MAX dimerization protein",TRUE
+"206522_at",0.769393110223875,0.276763332616305,1.11508440863945,-5.3515561837206,1.49143229640109,"MGAM","maltase-glucoamylase",TRUE
+"216666_at",0.909052380289506,0.622443316913736,0.499366988840502,-5.81895028258108,0.362226122507322,"MGAM2","maltase-glucoamylase 2 (putative)",TRUE
+"223734_at",0.0681210092794308,0.000185000937206572,4.47777588269687,0.831166086802387,3.60470401729967,"MGARP","mitochondria localized glutamic acid rich protein",TRUE
+"201126_s_at",0.960693014177181,0.821428110725982,0.228402565422393,-5.91430639633702,0.10690940371037,"MGAT1","mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase",TRUE
+"203102_s_at",0.740321726337106,0.228908652107786,-1.2373554709138,-5.22027088224467,-0.472005553738413,"MGAT2","mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase",TRUE
+"211061_s_at",0.757778451172575,0.253881768058148,-1.17139932899737,-5.29257222176654,-0.467575582682944,"MGAT2","mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase",TRUE
+"203101_s_at",0.950867616491248,0.77539023178859,-0.288838312299629,-5.89913048004606,-0.146820420565393,"MGAT2","mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase",TRUE
+"244104_at",0.68033297785336,0.147670574286573,-1.50023080522973,-4.89915545698639,-1.03554004103854,"MGAT3","mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase",TRUE
+"209764_at",0.920734496427305,0.662744473705509,-0.442040482506745,-5.84495698915061,-0.515810557577651,"MGAT3","mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase",TRUE
+"208058_s_at",0.949503174041699,0.771877908132283,-0.293491565063258,-5.89781604405851,-0.144431940527018,"MGAT3","mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase",TRUE
+"226039_at",0.819018525257656,0.374175032962649,-0.906982324513772,-5.54676808474493,-0.789025391202527,"MGAT4A","mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A",TRUE
+"219797_at",0.873407252402203,0.518692884965698,-0.655819617540437,-5.73234147961034,-0.56066659259537,"MGAT4A","mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A",TRUE
+"1569136_at",0.901857963753519,0.599886061742807,-0.532197261115512,-5.8026643360206,-0.501211941284084,"MGAT4A","mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A",TRUE
+"231283_at",0.921312278448293,0.664965562385018,-0.43892613893138,-5.84628092320042,-0.428600629848107,"MGAT4A","mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A",TRUE
+"220189_s_at",0.919185581492517,0.655946297816068,0.451600509060267,-5.84083558306795,0.136608621388655,"MGAT4B","mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B",TRUE
+"224598_at",0.924029559540466,0.673207736058623,0.427407373910101,-5.85109777746168,0.126361145620921,"MGAT4B","mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B",TRUE
+"207447_s_at",0.837067957688307,0.419338993049577,0.822890606571678,-5.61514376211424,0.806303630174397,"MGAT4C","MGAT4 family member C",TRUE
+"1569995_at",0.97689149311934,0.889580175267669,0.140441418661946,-5.9300813125279,0.0709748008386528,"MGAT4D","MGAT4 family member D",TRUE
+"1570023_at",0.68272466434042,0.150593870607553,-1.48896322122447,-4.91395639611619,-1.53750586597012,"MGAT4EP","MGAT4 family member E, pseudogene",TRUE
+"206720_at",0.917102138198416,0.649165394609079,-0.461179017032298,-5.83661951501989,-0.300577232086699,"MGAT5","mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase",TRUE
+"212098_at",0.950899620080917,0.77572886610826,-0.28839002301384,-5.89925601095789,-0.113860504030903,"MGAT5","mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase",TRUE
+"1563137_at",0.774230543658252,0.289856536669332,1.08437703769418,-5.38263404604702,0.481663434651934,"MGAT5B","mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B",TRUE
+"238445_x_at",0.919691066792211,0.658545100470897,-0.447940907700945,-5.8424234849745,-0.206139127915966,"MGAT5B","mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B",TRUE
+"224134_at",0.771422431667802,0.28057625013527,-1.10603527401769,-5.36079462593094,-0.761896214502681,"MGC10814","uncharacterized protein MGC10814",TRUE
+"211386_at",0.725583196024696,0.204318748810701,1.3078892671723,-5.13919343420497,0.981762173865699,"MGC12488","uncharacterized protein MGC12488",TRUE
+"224508_at",0.660093442228076,0.12812248356392,1.58067955286383,-4.79090712667863,1.27797038310475,"MGC12916","uncharacterized protein MGC12916",TRUE
+"238664_s_at",0.755719147268412,0.249985936118334,1.18135809525189,-5.28187633423815,0.817619592728455,"MGC12916","uncharacterized protein MGC12916",TRUE
+"224507_s_at",0.951810226174863,0.778848213680405,0.284263406766784,-5.90040246850666,0.210831762258735,"MGC12916","uncharacterized protein MGC12916",TRUE
+"1569393_at",0.915569510513076,0.644076669118515,-0.468396034276503,-5.83338562105411,-0.261038171963183,"MGC15885","uncharacterized protein MGC15885",TRUE
+"1553747_at",0.748438284778152,0.241296544132237,1.20399576528584,-5.25726960676553,0.93456298772516,"MGC16025","uncharacterized LOC85009",TRUE
+"1558167_a_at",0.910159094731364,0.626109596522,-0.494084103169312,-5.82147646573783,-0.191868420177133,"MGC16275","uncharacterized protein MGC16275",TRUE
+"1558166_at",0.948429371744093,0.765746775062879,0.301630261458672,-5.89546697552599,0.138122973472606,"MGC16275","uncharacterized protein MGC16275",TRUE
+"1554305_at",0.843475287501313,0.438715249533437,-0.788578017964345,-5.64125629077244,-0.44208967018518,"MGC20647","uncharacterized protein MGC20647",TRUE
+"232568_at",0.663309898243682,0.131291159665051,1.56697995369113,-4.80965581068641,0.736696394078018,"MGC24103","uncharacterized MGC24103",TRUE
+"231844_at",0.91508975903772,0.64219467863333,0.471071530285158,-5.83217425881573,0.15610487916725,"MGC27345///RBM28","uncharacterized protein MGC27345///RNA binding motif protein 28",TRUE
+"1570235_at",0.673366993714442,0.139306694388339,-1.53350837990268,-4.85492220874321,-1.34761491976645,"MGC27382","uncharacterized MGC27382",TRUE
+"211718_at",0.946727564264032,0.758328003205135,0.31150615788192,-5.89253098282424,0.235647087613149,"MGC2889","uncharacterized protein MGC2889",TRUE
+"1554781_at",0.897024165042344,0.582998462466785,0.557167227755272,-5.78960257384392,0.354093284829471,"MGC32805","uncharacterized LOC153163",TRUE
+"233475_at",0.980264692225439,0.90766002585569,-0.117324410404054,-5.93298127148465,-0.0791150888062502,"MGC32805","uncharacterized LOC153163",TRUE
+"240692_at",0.999503346640971,0.99872719333327,0.00161332234447595,-5.93968221301689,0.000899019826612779,"MGC34796","sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) pseudogene",TRUE
+"240814_at",0.966313390701604,0.84283861145398,-0.200603477531702,-5.92010219091828,-0.195651368398719,"MGC39584","uncharacterized LOC441058",TRUE
+"243602_at",0.943464796017993,0.746649043635873,0.327117968643945,-5.88769869376094,0.149167287947057,"MGC40069","uncharacterized protein MGC40069",TRUE
+"1555073_at",0.976392182310915,0.88744118524892,-0.143181284893266,-5.9297031880573,-0.0857881667517644,"MGC40069","uncharacterized protein MGC40069",TRUE
+"215524_x_at",0.643082025527735,0.113498905970274,1.64782236185446,-4.69718935067863,0.914768155615374,"MGC40069///TRAC///TRAJ17///TRAV20///TRDV2///YME1L1","uncharacterized protein MGC40069///T-cell receptor alpha constant///T cell receptor alpha joining 17///T cell receptor alpha variable 20///T cell receptor delta variable 2///YME1 like 1 ATPase",TRUE
+"1554222_at",0.990810941805126,0.953937594196828,0.0584202268838692,-5.93802130854324,0.0367861517648453,"MGC45922","uncharacterized LOC284365",TRUE
+"207775_at",0.826238242059762,0.394490318437763,-0.868389176232358,-5.57891597475837,-0.910167430199762,"MGC4859","uncharacterized LOC79150",TRUE
+"1559171_at",0.857750641191636,0.473343435684208,0.72949091736012,-5.68376101684702,0.456087523304829,"MGC57346","ADP-ribosylation factor pseudogene",TRUE
+"1553400_a_at",0.91524047167208,0.642417623801727,-0.470754402648815,-5.83231819490611,-0.173146300633337,"MGC57346///CRHR1-IT1","ADP-ribosylation factor pseudogene///CRHR1 intronic transcript 1",TRUE
+"1558611_at",0.956084625435459,0.801441635198888,-0.254519439240179,-5.9081806225082,-0.204237206386099,"MGC57346///CRHR1-IT1","ADP-ribosylation factor pseudogene///CRHR1 intronic transcript 1",TRUE
+"1568987_at",0.968066640321622,0.850121986463909,-0.19118470616778,-5.92189621288637,-0.0731363461050254,"MGC57346///CRHR1-IT1","ADP-ribosylation factor pseudogene///CRHR1 intronic transcript 1",TRUE
+"1553399_a_at",0.99420041915836,0.973581774892711,0.033492456205167,-5.93913713507104,0.0154318892291103,"MGC57346///CRHR1-IT1","ADP-ribosylation factor pseudogene///CRHR1 intronic transcript 1",TRUE
+"242136_x_at",0.725583196024696,0.204717737313614,1.3066937821721,-5.14059945834366,0.411650879653639,"MGC70870","C-terminal binding protein 2 pseudogene",TRUE
+"235868_at",0.54613142770476,0.0473655303423244,2.09966225822033,-3.99408561075151,0.718552814671991,"MGEA5","meningioma expressed antigen 5 (hyaluronidase)",TRUE
+"223494_at",0.709158363400091,0.181818992364089,1.37846986877797,-5.05427140259538,0.585630878495335,"MGEA5","meningioma expressed antigen 5 (hyaluronidase)",TRUE
+"200899_s_at",0.731054546207485,0.213773732499756,1.28003301196822,-5.17167179782924,0.39016175206674,"MGEA5","meningioma expressed antigen 5 (hyaluronidase)",TRUE
+"214972_at",0.768852835478002,0.273811965040449,1.12215137941824,-5.3442949951865,0.383275129994223,"MGEA5","meningioma expressed antigen 5 (hyaluronidase)",TRUE
+"200898_s_at",0.83093197294775,0.404789631448803,0.849315052445897,-5.59432490789631,0.312965735633664,"MGEA5","meningioma expressed antigen 5 (hyaluronidase)",TRUE
+"225102_at",0.985655660729344,0.930683938930997,-0.0879787026227582,-5.93591419239967,-0.0694790360382953,"MGLL","monoglyceride lipase",TRUE
+"211026_s_at",0.99647646582797,0.982643349457354,-0.0220019437100772,-5.93944770328747,-0.0160854445732692,"MGLL","monoglyceride lipase",TRUE
+"225890_at",0.978378450271268,0.896033384738904,-0.132181977653813,-5.9311770585078,-0.0510544046223558,"MGME1","mitochondrial genome maintenance exonuclease 1",TRUE
+"204880_at",0.966313390701604,0.842752919930207,0.200714401630306,-5.92008055090311,0.15008620931823,"MGMT","O-6-methylguanine-DNA methyltransferase",TRUE
+"238481_at",0.72844622680189,0.209893769676031,-1.29134643541571,-5.15855280336454,-2.06766720818289,"MGP","matrix Gla protein",TRUE
+"202291_s_at",0.769847953580141,0.278388018720649,-1.11121755218824,-5.35551210417111,-2.01775156223324,"MGP","matrix Gla protein",TRUE
+"212576_at",0.615821255316333,0.0868609989811504,-1.79163731178787,-4.48658645922672,-0.779763352918826,"MGRN1","mahogunin ring finger 1",TRUE
+"239001_at",0.611964994975857,0.0836995744385818,1.81113988854698,-4.45702976612044,2.1326247286427,"MGST1","microsomal glutathione S-transferase 1",TRUE
+"240688_at",0.671298718565642,0.137345526253901,1.54154807315353,-4.84411997929171,1.7590006227473,"MGST1","microsomal glutathione S-transferase 1",TRUE
+"231736_x_at",0.727286289873957,0.207611077052193,1.29807820952305,-5.15070011773175,1.17980620614818,"MGST1","microsomal glutathione S-transferase 1",TRUE
+"224918_x_at",0.735742230654287,0.220917790592619,1.25960922347319,-5.19510555574794,1.17314378040143,"MGST1","microsomal glutathione S-transferase 1",TRUE
+"1565162_s_at",0.757950630724418,0.254523471615631,1.16976990156506,-5.29431471615006,1.23651137572829,"MGST1","microsomal glutathione S-transferase 1",TRUE
+"204168_at",0.806649582904638,0.347814710907846,0.959188260088714,-5.5012329338112,0.592909964762292,"MGST2","microsomal glutathione S-transferase 2",TRUE
+"233307_x_at",0.774230543658252,0.290075614297477,-1.08387184155291,-5.38313887565159,-0.57696209591147,"MGST3","microsomal glutathione S-transferase 3",TRUE
+"244122_at",0.880370695519495,0.53579030440624,0.628985226001431,-5.74880591433505,0.225795487163369,"MGST3","microsomal glutathione S-transferase 3",TRUE
+"201403_s_at",0.940227139261806,0.732270926941988,0.346452889427678,-5.88138998562486,0.17737636452911,"MGST3","microsomal glutathione S-transferase 3",TRUE
+"206560_s_at",0.686950785936014,0.155448352838906,1.47063942852296,-4.93783422180459,2.07932813153812,"MIA","melanoma inhibitory activity",TRUE
+"228521_s_at",0.748184017928985,0.240658119607858,-1.20568298340329,-5.25541937299182,-0.591778466438397,"MIA-RAB4B///RAB4B","MIA-RAB4B readthrough (NMD candidate)///RAB4B, member RAS oncogene family",TRUE
+"219807_x_at",0.748438284778152,0.241312877455496,-1.20395264393578,-5.25731686493207,-0.914886432954953,"MIA-RAB4B///RAB4B","MIA-RAB4B readthrough (NMD candidate)///RAB4B, member RAS oncogene family",TRUE
+"233385_x_at",0.869056640409671,0.505518979821841,-0.676830447300842,-5.71898982861032,-0.477893627312325,"MIA-RAB4B///RAB4B","MIA-RAB4B readthrough (NMD candidate)///RAB4B, member RAS oncogene family",TRUE
+"221177_at",0.686108994812404,0.154600051244013,1.47380759155155,-4.93372284343191,1.0462218596215,"MIA2","melanoma inhibitory activity 2",TRUE
+"1553944_at",0.778686132916778,0.29921797671856,1.06302919806808,-5.40378306817704,0.708557715098832,"MIA2///CTAGE5","melanoma inhibitory activity 2///CTAGE family member 5, ER export factor",TRUE
+"1560148_at",0.695199033310042,0.164711628303581,1.43692380803413,-4.98114217181721,0.977432034721089,"MIA3","MIA family member 3, ER export factor",TRUE
+"212305_s_at",0.877861946695164,0.529266082259454,-0.639169159173525,-5.74263531511335,-0.221132489139061,"MIA3","MIA family member 3, ER export factor",TRUE
+"1569057_s_at",0.929972194057784,0.691052071611171,-0.402666785553624,-5.86101788499146,-0.159515861199512,"MIA3","MIA family member 3, ER export factor",TRUE
+"212310_at",0.985425981490741,0.928956008071853,0.0901780076095915,-5.93572342383911,0.0467581484861554,"MIA3","MIA family member 3, ER export factor",TRUE
+"228658_at",0.712975827977365,0.187520988848231,1.3599599418879,-5.07690356048924,0.442564755855072,"MIAT","myocardial infarction associated transcript (non-protein coding)",TRUE
+"240607_at",0.755049574909504,0.248988961713766,1.18392520855559,-5.27910639216201,0.762832035764375,"MIAT","myocardial infarction associated transcript (non-protein coding)",TRUE
+"227168_at",0.930083070178974,0.691491865809392,0.402060305600931,-5.86125375515099,0.145717503727859,"MIAT","myocardial infarction associated transcript (non-protein coding)",TRUE
+"237322_at",0.94895689004559,0.769065822130172,-0.297221887664072,-5.89674727040319,-0.104136694790859,"MIAT","myocardial infarction associated transcript (non-protein coding)",TRUE
+"232310_at",0.965580083724105,0.838883613008578,-0.205725766177882,-5.91909046240215,-0.152641408002826,"MIATNB","MIAT neighbor (non-protein coding)",TRUE
+"232340_at",0.984244246588495,0.923308677626638,-0.0973691509251008,-5.93506681098262,-0.0472802820435891,"MIATNB","MIAT neighbor (non-protein coding)",TRUE
+"224720_at",0.477709967865451,0.0265620089788627,2.37604450611891,-3.51036918234022,0.800364416426705,"MIB1","mindbomb E3 ubiquitin protein ligase 1",TRUE
+"224726_at",0.672434875127089,0.138471694286641,1.53691994858159,-4.85034385353782,0.63117623364929,"MIB1","mindbomb E3 ubiquitin protein ligase 1",TRUE
+"224722_at",0.724067243569133,0.201379652304355,1.31675207898799,-5.12873587738718,0.774089684953609,"MIB1","mindbomb E3 ubiquitin protein ligase 1",TRUE
+"224725_at",0.812302873476553,0.360069106976887,0.934600179977383,-5.52297085424854,0.277122309239781,"MIB1","mindbomb E3 ubiquitin protein ligase 1",TRUE
+"241378_at",0.51470556386048,0.0351896568076215,2.24341621934842,-3.74697011467062,0.752800671825744,"MIB2","mindbomb E3 ubiquitin protein ligase 2",TRUE
+"226644_at",0.736256800969852,0.221759067185579,-1.25723765618835,-5.19780573244477,-1.01290178165332,"MIB2","mindbomb E3 ubiquitin protein ligase 2",TRUE
+"228261_at",0.908619002315341,0.619802422916816,0.503181291887446,-5.81711004599323,0.216834944000449,"MIB2","mindbomb E3 ubiquitin protein ligase 2",TRUE
+"241541_at",0.929234395612144,0.688889057325313,0.405651843544084,-5.85985184583132,0.271343114234637,"MIB2","mindbomb E3 ubiquitin protein ligase 2",TRUE
+"241377_s_at",0.98539961718117,0.927688291770658,-0.0917918421806901,-5.93558044543731,-0.0686952672907255,"MIB2","mindbomb E3 ubiquitin protein ligase 2",TRUE
+"205904_at",0.98529096111871,0.92690613809583,-0.0927876677009854,-5.93549095559727,-0.0623668746265551,"MICA","MHC class I polypeptide-related sequence A",TRUE
+"205905_s_at",0.918409982899324,0.653617333407118,0.454885456320082,-5.83939945505484,0.301787582249959,"MICA///MICB","MHC class I polypeptide-related sequence A///MHC class I polypeptide-related sequence B",TRUE
+"218376_s_at",0.663789119801086,0.131720722294376,1.5651439221706,-4.81215879108273,1.27776948896176,"MICAL1","microtubule associated monooxygenase, calponin and LIM domain containing 1",TRUE
+"206275_s_at",0.588570129409209,0.0671513574257823,1.92508530248356,-4.27980655999318,0.989000103532032,"MICAL2","microtubule associated monooxygenase, calponin and LIM domain containing 2",TRUE
+"236475_at",0.596382916302699,0.0727487818063401,1.88403960394374,-4.34452413539392,1.21097744900873,"MICAL2","microtubule associated monooxygenase, calponin and LIM domain containing 2",TRUE
+"212473_s_at",0.65284137151906,0.121712879703931,1.60927551551687,-4.75136195130622,1.52662588971452,"MICAL2","microtubule associated monooxygenase, calponin and LIM domain containing 2",TRUE
+"212472_at",0.672329541745581,0.138179553005854,1.53811755232144,-4.84873474550645,1.27837877365199,"MICAL2","microtubule associated monooxygenase, calponin and LIM domain containing 2",TRUE
+"231553_s_at",0.885014154181347,0.545155769523065,-0.614482124779855,-5.7574288181276,-0.183272234291134,"MICAL3","microtubule associated monooxygenase, calponin and LIM domain containing 3",TRUE
+"229474_at",0.93667390723462,0.717267940499861,0.366772806079413,-5.87437418678915,0.108658857087992,"MICAL3","microtubule associated monooxygenase, calponin and LIM domain containing 3",TRUE
+"231985_at",0.961212424803935,0.823136995852291,-0.226177298555132,-5.9147978666801,-0.12283587083293,"MICAL3","microtubule associated monooxygenase, calponin and LIM domain containing 3",TRUE
+"212715_s_at",0.989475734766121,0.948012624262163,-0.0659455160342141,-5.9375655571696,-0.0322446001826737,"MICAL3","microtubule associated monooxygenase, calponin and LIM domain containing 3",TRUE
+"243611_at",0.695744345349551,0.165343285624395,1.43468097949833,-4.9839940582505,1.12230404549474,"MICALCL","MICAL C-terminal like",TRUE
+"55081_at",0.493519901382617,0.0299125032767277,2.32040370615678,-3.61058580334863,1.52108171258172,"MICALL1","MICAL like 1",TRUE
+"221779_at",0.522667179791589,0.0384030821700469,2.20155560921595,-3.81997024924493,1.7578335134484,"MICALL1","MICAL like 1",TRUE
+"241478_at",0.872059365573905,0.514909785072197,0.661822499397369,-5.72856802369084,0.308225145245666,"MICALL2","MICAL like 2",TRUE
+"1555862_s_at",0.920169584950428,0.660243514471628,0.445552578466831,-5.84345294768477,0.470608877850772,"MICALL2","MICAL like 2",TRUE
+"219332_at",0.925511384407886,0.677807416724415,0.421004701705672,-5.85372079156971,0.209618721617591,"MICALL2","MICAL like 2",TRUE
+"206247_at",0.643082025527735,0.113637227278626,1.64715413003339,-4.69813684964472,1.39286981300882,"MICB","MHC class I polypeptide-related sequence B",TRUE
+"216903_s_at",0.779119049888702,0.300212203730004,1.06079015414386,-5.40597944762773,0.329749940577686,"MICU1","mitochondrial calcium uptake 1",TRUE
+"212410_at",0.358427723880268,0.0101030442862017,-2.81239242231908,-2.68269879469943,-0.985574504475954,"MICU2","mitochondrial calcium uptake 2",TRUE
+"238458_at",0.974536463688956,0.875364000052655,-0.158672862086098,-5.92742808962208,-0.284920234887627,"MICU3","mitochondrial calcium uptake family member 3",TRUE
+"203637_s_at",0.801587742916188,0.338939058628893,0.977366730296266,-5.48482986117917,1.47670674738453,"MID1","midline 1",TRUE
+"203636_at",0.875638194926234,0.52315678601665,0.64876747060892,-5.73673236718383,0.949165861993531,"MID1","midline 1",TRUE
+"210694_s_at",0.961212424803935,0.823509282247119,0.225692671932689,-5.91490426594322,0.0843648033876843,"MID1","midline 1",TRUE
+"218251_at",0.975449397348071,0.882672935763237,-0.149293085497854,-5.92883343772143,-0.0627582478442807,"MID1IP1","MID1 interacting protein 1",TRUE
+"208384_s_at",0.385141328160291,0.0126484836205989,-2.71319538393923,-2.87671066585042,-1.01233851294458,"MID2","midline 2",TRUE
+"209733_at",0.406795337445118,0.0154343207103475,-2.62429719664533,-3.04785492904783,-1.01352567857525,"MID2","midline 2",TRUE
+"225954_s_at",0.452969693655811,0.0218386486049697,-2.46665652180976,-3.34435747046492,-0.91687842974191,"MIDN","midnolin",TRUE
+"231072_at",0.915353407558177,0.643048949032975,-0.469856641697184,-5.83272515104623,-0.222418064091193,"MIDN","midnolin",TRUE
+"227398_s_at",0.976422537443518,0.887817585910482,0.142699066548922,-5.9297702669341,0.108712266893773,"MIDN","midnolin",TRUE
+"204593_s_at",0.984004604128855,0.921558573543625,-0.0995987315684461,-5.93485301435733,-0.0387507756545311,"MIEF1","mitochondrial elongation factor 1",TRUE
+"204594_s_at",0.984090001104476,0.921826281013872,0.099257646977833,-5.93488603457905,0.0357276924842012,"MIEF1","mitochondrial elongation factor 1",TRUE
+"224319_s_at",0.993615552413264,0.9700944969664,0.0379156375027319,-5.93898330520927,0.0148482285627889,"MIEF1","mitochondrial elongation factor 1",TRUE
+"221516_s_at",0.995025131654789,0.97669843090734,0.0295399451533831,-5.93925847432728,0.0106961599530067,"MIEF1","mitochondrial elongation factor 1",TRUE
+"235896_s_at",0.590570903980459,0.068326856299696,1.91622277113782,-4.29386236137139,0.729136347296357,"MIEF2","mitochondrial elongation factor 2",TRUE
+"224447_s_at",0.76145107371764,0.260537847897327,-1.1546443668054,-5.31038833290324,-0.942710308139187,"MIEN1","migration and invasion enhancer 1",TRUE
+"240227_at",0.54613142770476,0.047350429450118,2.0998187551229,-3.99382219583079,0.875503641984166,"MIER1","MIER1 transcriptional regulator",TRUE
+"225475_at",0.982441995162923,0.91520289235726,0.107700118862144,-5.93403546050572,0.0403835004674455,"MIER1","MIER1 transcriptional regulator",TRUE
+"1555105_a_at",0.989586772349659,0.949104860370246,0.0645579895558566,-5.93765373503568,0.0284141851506625,"MIER1","MIER1 transcriptional regulator",TRUE
+"221862_at",0.595936234743389,0.0723828152075288,1.88663713843969,-4.34045744553506,0.993116768300143,"MIER2","MIER family member 2",TRUE
+"221863_at",0.941766906602305,0.73873798061929,0.337740124172289,-5.88427717872977,0.219984670368317,"MIER2","MIER family member 2",TRUE
+"44822_s_at",0.966064677476069,0.841916761328742,-0.201796909481279,-5.91986874050795,-0.0705253273675499,"MIER2","MIER family member 2",TRUE
+"1554449_at",0.227168192678334,0.00284317864330327,-3.354903045141,-1.57641646277055,-1.37415265625296,"MIER3","MIER family member 3",TRUE
+"231975_s_at",0.425751189365875,0.0182759586912064,-2.54798924155863,-3.1925462249996,-0.86977833558605,"MIER3","MIER family member 3",TRUE
+"228961_at",0.454075331297806,0.0219583937073873,-2.46414348890576,-3.34900690845843,-0.920318910778708,"MIER3","MIER family member 3",TRUE
+"1553336_a_at",0.47652109797903,0.0263695435193621,-2.37943379777635,-3.50422133267988,-0.937118970949076,"MIER3","MIER family member 3",TRUE
+"1554450_s_at",0.589317543236157,0.0677755594306164,-1.92036238292032,-4.28730260568579,-0.843633557324203,"MIER3","MIER family member 3",TRUE
+"217871_s_at",0.807944276806637,0.349676684589882,-0.95541491259892,-5.50460247536741,-0.235036679931447,"MIF","macrophage migration inhibitory factor (glycosylation-inhibiting factor)",TRUE
+"1556316_s_at",0.995025131654789,0.976646565859601,0.0296057157477062,-5.93925657970952,0.0283494464173897,"MIF-AS1","MIF antisense RNA 1",TRUE
+"223411_at",0.95388518141013,0.786949024687379,-0.273570067463019,-5.90329699028035,-0.14033850001039,"MIF4GD","MIF4G domain containing",TRUE
+"231727_s_at",0.962125056232529,0.828016205388154,-0.219830096749284,-5.9161733949402,-0.12585725757962,"MIF4GD","MIF4G domain containing",TRUE
+"243042_at",0.876632890672003,0.525528963893522,0.645033307797828,-5.73903891688372,0.314036743823895,"MIGA1","mitoguardin 1",TRUE
+"235125_x_at",0.995517970857919,0.978879188196164,0.02677462183361,-5.93933432078196,0.0132842894181344,"MIGA1","mitoguardin 1",TRUE
+"226356_at",0.790240875783718,0.319569538309228,-1.01820714395604,-5.44695744884793,-0.270419091050419,"MIGA2","mitoguardin 2",TRUE
+"48659_at",0.888312537451395,0.554299128219181,0.600449988696995,-5.76558703906097,0.16262083109865,"MIIP","migration and invasion inhibitory protein",TRUE
+"218551_at",0.92563477467988,0.678537350621682,0.419990296991246,-5.85413279655943,0.187229703680771,"MIIP","migration and invasion inhibitory protein",TRUE
+"217513_at",0.518874125067442,0.0372798888956108,2.21581218759377,-3.7952020391908,2.26524817826044,"MILR1","mast cell immunoglobulin like receptor 1",TRUE
+"229675_at",0.732320150624823,0.216714459342969,1.27156331072036,-5.18142880483461,0.664843841811912,"MINA","MYC induced nuclear antigen",TRUE
+"229132_at",0.859064198633089,0.47569857899113,0.72556729931082,-5.68647242701364,0.236514458176469,"MINA","MYC induced nuclear antigen",TRUE
+"213189_at",0.861981304384929,0.484694857457107,-0.710683297538546,-5.69663153185211,-0.260886680140226,"MINA","MYC induced nuclear antigen",TRUE
+"213188_s_at",0.942450624660433,0.74137271005726,-0.334198141020788,-5.88543011134122,-0.127957504460582,"MINA","MYC induced nuclear antigen",TRUE
+"1554774_at",0.975401809987074,0.882508948083047,-0.149503382275776,-5.92880286554605,-0.0529294873063817,"MINA","MYC induced nuclear antigen",TRUE
+"243749_s_at",0.853240692307503,0.45974340732289,0.752377140540342,-5.66766914984278,0.401937415889964,"MINCR","MYC-induced long noncoding RNA",TRUE
+"235428_at",0.89316156038085,0.566979176051124,-0.5811886653089,-5.77648890617498,-0.329706722950059,"MINCR","MYC-induced long noncoding RNA",TRUE
+"244411_at",0.945498722604777,0.753734647462488,-0.317636671618237,-5.89066131639623,-0.0982801801366833,"MINCR","MYC-induced long noncoding RNA",TRUE
+"209241_x_at",0.363351036751142,0.0105599414247383,2.79295652529882,-2.72095223588349,0.912719219732641,"MINK1","misshapen like kinase 1",TRUE
+"215909_x_at",0.51531387545335,0.0356499024136173,2.23721230694917,-3.75784141682279,0.653215946489548,"MINK1","misshapen like kinase 1",TRUE
+"214625_s_at",0.53309539883286,0.0420626163797889,2.1575934723894,-3.89572589752258,1.59621249179756,"MINK1","misshapen like kinase 1",TRUE
+"214246_x_at",0.643668420247444,0.114253351961618,1.64418591278318,-4.70234198668083,0.601491642069298,"MINK1","misshapen like kinase 1",TRUE
+"228096_at",0.62110896023334,0.0913363767417899,-1.76505021669672,-4.52650395261965,-1.43634974747885,"MINOS1","mitochondrial inner membrane organizing system 1",TRUE
+"224867_at",0.825376550784618,0.39282942120745,-0.871495073161374,-5.57637675846819,-0.214760696837683,"MINOS1","mitochondrial inner membrane organizing system 1",TRUE
+"37005_at",0.819030260228921,0.375362872483673,0.904688447444241,-5.54871501624488,0.888673872007569,"MINOS1-NBL1///NBL1","MINOS1-NBL1 readthrough///neuroblastoma 1, DAN family BMP antagonist",TRUE
+"215318_at",0.737123149977386,0.223124983542619,1.25340175121364,-5.20216391249756,0.840574256115574,"MINOS1P1","mitochondrial inner membrane organizing system 1 pseudogene 1",TRUE
+"209585_s_at",0.975475861996229,0.883036777904783,-0.148826521204789,-5.92890111180975,-0.0568941341082372,"MINPP1","multiple inositol-polyphosphate phosphatase 1",TRUE
+"206860_s_at",0.740270784944871,0.22866408806767,1.23802769864241,-5.21951635468587,0.372586815096996,"MIOS","meiosis regulator for oocyte development",TRUE
+"209672_s_at",0.858826390511142,0.474779873404172,0.727096483582982,-5.68541733882893,0.439135654842452,"MIOS","meiosis regulator for oocyte development",TRUE
+"211724_x_at",0.860026478479837,0.478567519386484,0.720803055660887,-5.68974606461655,0.192739934343415,"MIOS","meiosis regulator for oocyte development",TRUE
+"224179_s_at",0.816199380744005,0.367205564546356,0.92053944002387,-5.53516860249895,0.360592476149703,"MIOX","myo-inositol oxygenase",TRUE
+"220863_at",0.964685626382167,0.836755878607885,0.208483808857737,-5.91853518589557,0.102242533039213,"MIP","major intrinsic protein of lens fiber",TRUE
+"36830_at",0.76159330462167,0.260731363970872,-1.1541620078531,-5.31089790582512,-0.46795324292124,"MIPEP","mitochondrial intermediate peptidase",TRUE
+"204305_at",0.768852835478002,0.273620302030593,-1.12261223010027,-5.34382006903842,-0.466480938436719,"MIPEP","mitochondrial intermediate peptidase",TRUE
+"243760_at",0.896229101808264,0.580006584052618,0.56162813968687,-5.78720786775722,0.198643216614308,"MIPEPP3","mitochondrial intermediate peptidase pseudogene 3",TRUE
+"236837_x_at",0.90105641459739,0.597429492956074,-0.535807956306434,-5.80081158910189,-0.26381369533792,"MIPEPP3","mitochondrial intermediate peptidase pseudogene 3",TRUE
+"240436_at",0.932633693661011,0.702663386451866,-0.386705296452671,-5.86710889093435,-0.159198755422918,"MIPEPP3","mitochondrial intermediate peptidase pseudogene 3",TRUE
+"1570052_at",0.463598473166611,0.0237125780119539,2.42871816260162,-3.41427716066605,1.79304488796093,"MIPOL1","mirror-image polydactyly 1",TRUE
+"244246_at",0.811429110784149,0.35555955438805,0.943581804919412,-5.51509035230751,0.447581819992989,"MIPOL1","mirror-image polydactyly 1",TRUE
+"1552573_s_at",0.89557187288274,0.574754850435893,-0.569486525581732,-5.78294428640368,-0.239359465589358,"MIPOL1","mirror-image polydactyly 1",TRUE
+"1552572_a_at",0.99135920925157,0.9594108795451,-0.0514717017498039,-5.93839316920577,-0.0244001874287338,"MIPOL1","mirror-image polydactyly 1",TRUE
+"232892_at",0.868541339434524,0.504595926506378,0.678314034787887,-5.718031827198,0.310104932142163,"MIR1-1HG","MIR1-1 host gene",TRUE
+"225381_at",0.54295328972902,0.0458883814838146,2.11518723043323,-3.9678929018394,3.6352755651055,"MIR100HG","mir-100-let-7a-2 cluster host gene",TRUE
+"241975_at",0.741816732763138,0.232370370270069,1.22789836923821,-5.2308483466403,0.8960055617708,"MIR100HG","mir-100-let-7a-2 cluster host gene",TRUE
+"232979_at",0.821745015752602,0.38454659720935,0.887112728393731,-5.56348108692313,0.79067790440613,"MIR10A","microRNA 10a",TRUE
+"212801_at",0.839466826665106,0.425780280947695,0.811376557549833,-5.6240225383718,0.249843003413231,"MIR1178///CIT","microRNA 1178///citron rho-interacting serine/threonine kinase",TRUE
+"242872_at",0.943464796017993,0.746532916352906,0.327273612014284,-5.88764934029274,0.288532331270638,"MIR1178///CIT","microRNA 1178///citron rho-interacting serine/threonine kinase",TRUE
+"226448_at",0.853793505235478,0.462611417116741,0.747517698508659,-5.67112534012953,0.484958207394828,"MIR1182///FAM89A","microRNA 1182///family with sequence similarity 89 member A",TRUE
+"1558412_at",0.868045863234681,0.501836092284558,-0.682758960877249,-5.7151495841098,-0.433551794027135,"MIR1199///MISP3","microRNA 1199///MISP family member 3",TRUE
+"222087_at",0.690381347688918,0.160088888050045,1.45355217704762,-4.95988496639831,1.12833354094144,"MIR1204///PVT1","microRNA 1204///Pvt1 oncogene (non-protein coding)",TRUE
+"216240_at",0.78809916745704,0.314259497922238,1.02970319230533,-5.43604379153477,0.652317139765005,"MIR1204///PVT1","microRNA 1204///Pvt1 oncogene (non-protein coding)",TRUE
+"1558290_a_at",0.914548427579679,0.639983876091221,-0.474218940677737,-5.83074058723245,-0.22479887772818,"MIR1204///PVT1","microRNA 1204///Pvt1 oncogene (non-protein coding)",TRUE
+"1562153_a_at",0.915409740314202,0.64342380101097,0.469323777809094,-5.83296633926175,0.35373682493329,"MIR1204///PVT1","microRNA 1204///Pvt1 oncogene (non-protein coding)",TRUE
+"209219_at",0.759759632795787,0.257574843228216,1.16206328833817,-5.30252730692973,0.373719811421743,"MIR1236///NELFE","microRNA 1236///negative elongation factor complex member E",TRUE
+"1556046_a_at",0.59507179340408,0.0720072242370625,1.88931495681698,-4.3362609494124,1.00299713647336,"MIR124-1///LINC00599","microRNA 124-1///long intergenic non-protein coding RNA 599",TRUE
+"214839_at",0.647754107214051,0.119060237249983,1.62147902285658,-4.73431843873578,0.838313751857935,"MIR124-1///LINC00599","microRNA 124-1///long intergenic non-protein coding RNA 599",TRUE
+"236693_at",0.383430183351526,0.0122445194354232,2.7275973490571,-2.84873598349161,1.44173415414396,"MIR124-2HG","MIR124-2 host gene",TRUE
+"238661_at",0.88782282220852,0.553140566546476,-0.602221241515443,-5.76456727225904,-0.499809885361877,"MIR124-2HG","MIR124-2 host gene",TRUE
+"242193_at",0.930908124163614,0.694601332114839,-0.397776683896058,-5.86290975851582,-0.364077160665564,"MIR124-2HG","MIR124-2 host gene",TRUE
+"216515_x_at",0.874474734833648,0.520532853039572,-0.652908772349817,-5.73415938425522,-0.139207215260059,"MIR1244-3","microRNA 1244-3",TRUE
+"239727_at",0.919695424525124,0.658633706180419,0.447816244004194,-5.84247735340623,0.362589720673793,"MIR1247///DIO3OS","microRNA 1247///DIO3 opposite strand/antisense RNA (head to head)",TRUE
+"1555996_s_at",0.881822289535728,0.538719992451135,0.624433916588711,-5.75153278156259,0.295342120305568,"MIR1248///SNORA81///SNORA4///SNORD2///SNORA63///EIF4A2","microRNA 1248///small nucleolar RNA, H/ACA box 81///small nucleolar RNA, H/ACA box 4///small nucleolar RNA, C/D box 2///small nucleolar RNA, H/ACA box 63///eukaryotic translation initiation factor 4A2",TRUE
+"200912_s_at",0.881970070870254,0.53919063773492,0.623704002213074,-5.75196832744524,0.185121627726129,"MIR1248///SNORA81///SNORA4///SNORD2///SNORA63///EIF4A2","microRNA 1248///small nucleolar RNA, H/ACA box 81///small nucleolar RNA, H/ACA box 4///small nucleolar RNA, C/D box 2///small nucleolar RNA, H/ACA box 63///eukaryotic translation initiation factor 4A2",TRUE
+"217756_x_at",0.51470556386048,0.0353429920328523,-2.2413411533976,-3.75060832612135,-0.844209740766667,"MIR1282///HYPK///SERF2","microRNA 1282///huntingtin interacting protein K///small EDRK-rich factor 2",TRUE
+"224625_x_at",0.615668817664405,0.0861767436961261,-1.79580582529681,-4.48028846983508,-0.564674312969018,"MIR1282///HYPK///SERF2","microRNA 1282///huntingtin interacting protein K///small EDRK-rich factor 2",TRUE
+"226692_at",0.670970797333726,0.136912870466181,-1.54333444060229,-4.84171371915448,-0.512132831790176,"MIR1282///HYPK///SERF2","microRNA 1282///huntingtin interacting protein K///small EDRK-rich factor 2",TRUE
+"200875_s_at",0.994061569423518,0.972407663082715,0.034981591043263,-5.93908747346843,0.0172554066080171,"MIR1292///SNORD110///SNORD86///SNORD57///NOP56","microRNA 1292///small nucleolar RNA, C/D box 110///small nucleolar RNA, C/D box 86///small nucleolar RNA, C/D box 57///NOP56 ribonucleoprotein",TRUE
+"200874_s_at",0.999328749224215,0.9978299845706,0.00275056495071063,-5.93967979582128,0.000939095691913749,"MIR1292///SNORD110///SNORD86///SNORD57///NOP56","microRNA 1292///small nucleolar RNA, C/D box 110///small nucleolar RNA, C/D box 86///small nucleolar RNA, C/D box 57///NOP56 ribonucleoprotein",TRUE
+"222728_s_at",0.380084968057051,0.0117340522199809,2.74645340396799,-2.81200851904204,1.31661127820326,"MIR1304///SNORD5///SNORA32///SNORA40///SNORA18///SNORA1///SNORA8///TAF1D","microRNA 1304///small nucleolar RNA, C/D box 5///small nucleolar RNA, H/ACA box 32///small nucleolar RNA, H/ACA box 40///small nucleolar RNA, H/ACA box 18///small nucleolar RNA, H/ACA box 1///small nucleolar RNA, H/ACA box 8///TATA-box binding protein associated factor, RNA polymerase I subunit D",TRUE
+"221580_s_at",0.560923390313819,0.0545096328205384,2.03020715491984,-4.10973128942461,1.01445957649583,"MIR1304///SNORD5///SNORA32///SNORA40///SNORA18///SNORA1///SNORA8///TAF1D","microRNA 1304///small nucleolar RNA, C/D box 5///small nucleolar RNA, H/ACA box 32///small nucleolar RNA, H/ACA box 40///small nucleolar RNA, H/ACA box 18///small nucleolar RNA, H/ACA box 1///small nucleolar RNA, H/ACA box 8///TATA-box binding protein associated factor, RNA polymerase I subunit D",TRUE
+"64474_g_at",0.640067422642767,0.11067410566064,-1.66162135237739,-4.67755790097544,-0.43333464186597,"MIR1306///DGCR8","microRNA 1306///DGCR8 microprocessor complex subunit",TRUE
+"218650_at",0.934784679606929,0.710466538999586,-0.376036126681571,-5.87104491251753,-0.123167254892889,"MIR1306///DGCR8","microRNA 1306///DGCR8 microprocessor complex subunit",TRUE
+"219811_at",0.950491834313282,0.774735593894311,0.289705103416459,-5.89888721082711,0.094846706054442,"MIR1306///DGCR8","microRNA 1306///DGCR8 microprocessor complex subunit",TRUE
+"91617_at",0.981158705865426,0.911214843940556,0.112787296554708,-5.93348946195215,0.0324682150121411,"MIR1306///DGCR8","microRNA 1306///DGCR8 microprocessor complex subunit",TRUE
+"1558645_at",0.923758661165355,0.67260781529022,0.428243787523286,-5.85075224687383,0.296178984008649,"MIR133A1HG","MIR133A1 host gene",TRUE
+"236573_at",0.90344422113846,0.60449492246669,0.52544232084994,-5.80609773980192,0.422615645602877,"MIR133A1HG///MIR133A1///MIR1-2","MIR133A1 host gene///microRNA 133a-1///microRNA 1-2",TRUE
+"230805_at",0.841813886364358,0.434053288519252,0.796746425976258,-5.63513475411448,0.334803740276311,"MIR142","microRNA 142",TRUE
+"230980_x_at",0.956734254923335,0.804088645537576,0.251050509527003,-5.90903220388779,0.0875417600185413,"MIR142","microRNA 142",TRUE
+"232504_at",0.627087721741888,0.0979251700759995,1.72787464717987,-4.58158103835625,1.16965175122678,"MIR146A","microRNA 146a",TRUE
+"238225_at",0.887929552412429,0.55335008523125,-0.601900777663378,-5.76475198844767,-0.209009362783713,"MIR146A","microRNA 146a",TRUE
+"229437_at",0.299994279961527,0.00560308966861133,3.06776128333938,-2.17034648187096,4.20607598453958,"MIR155///MIR155HG","microRNA 155///MIR155 host gene",TRUE
+"1563229_at",0.834265235157814,0.41219391684019,-0.835793550183209,-5.60505482771864,-0.590718810335463,"MIR15A///DLEU2","microRNA 15a///deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"239936_at",0.87269168822074,0.516863324151148,-0.65871965809415,-5.73052260918137,-0.66297195254903,"MIR15A///DLEU2","microRNA 15a///deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"215629_s_at",0.805746717966166,0.345794068882766,0.963298721205638,-5.49754853348439,0.686391628703873,"MIR15A///DLEU2L///DLEU2","microRNA 15a///deleted in lymphocytic leukemia 2-like///deleted in lymphocytic leukemia 2 (non-protein coding)",TRUE
+"233636_at",0.843095426822889,0.437372326644662,0.79092550399627,-5.63950312611941,0.807088580492473,"MIR17HG","miR-17-92a-1 cluster host gene",TRUE
+"232291_at",0.643082025527735,0.113676649944958,1.64696380403223,-4.69840666278962,1.25992687533226,"MIR17HG///MIR92A1///MIR20A///MIR19B1///MIR19A///MIR18A///MIR17","miR-17-92a-1 cluster host gene///microRNA 92a-1///microRNA 20a///microRNA 19b-1///microRNA 19a///microRNA 18a///microRNA 17",TRUE
+"232478_at",0.893859847265625,0.56937267564767,0.577577863795453,-5.77849433640814,0.658755949186309,"MIR181A2HG","MIR181A2 host gene",TRUE
+"241345_at",0.956734254923335,0.803676488208612,-0.251590437236267,-5.90890042120057,-0.108429943890797,"MIR186///ZRANB2","microRNA 186///zinc finger RANBP2-type containing 2",TRUE
+"208963_x_at",0.820536502908875,0.380242793537245,0.895314569650776,-5.55662374240557,1.00371639791699,"MIR1908///FADS1","microRNA 1908///fatty acid desaturase 1",TRUE
+"208962_s_at",0.849144743801275,0.449926350762193,0.769149879624115,-5.65557712980841,0.662632524479283,"MIR1908///FADS1","microRNA 1908///fatty acid desaturase 1",TRUE
+"208964_s_at",0.897375964261386,0.583886464481227,0.555845410726586,-5.79030859237136,0.336736349279805,"MIR1908///FADS1","microRNA 1908///fatty acid desaturase 1",TRUE
+"226144_at",0.995842957164806,0.979960468666449,-0.0254035778965772,-5.93936916345472,-0.00985121178885962,"MIR1909///REXO1","microRNA 1909///RNA exonuclease 1 homolog",TRUE
+"1556717_at",0.758920166935337,0.256237609325361,1.16543224724747,-5.29894301023018,0.465363782734794,"MIR194-2","microRNA 194-2",TRUE
+"1556718_s_at",0.986361618040699,0.935716691836274,0.0815755223011141,-5.93644280677165,0.0402321800191814,"MIR194-2","microRNA 194-2",TRUE
+"1555942_a_at",0.316591802768735,0.00686166047153088,2.98069920060613,-2.34693165614785,3.30076662444794,"MIR205","microRNA 205",TRUE
+"1561371_at",0.899458534411407,0.590245500798297,0.546408800098644,-5.7953016334326,0.341217600737679,"MIR2052HG","MIR2052 host gene",TRUE
+"226755_at",0.503066995427577,0.0325716902389323,2.28018088139057,-3.68217871049504,2.96733221350773,"MIR205HG","MIR205 host gene",TRUE
+"231697_s_at",0.896115372949367,0.577712343161619,0.56505668314905,-5.78535476898448,0.497085906244674,"MIR21///VMP1","microRNA 21///vacuole membrane protein 1",TRUE
+"220990_s_at",0.933298127911264,0.704879159851773,-0.383671098030919,-5.86823930127299,-0.168926375821037,"MIR21///VMP1","microRNA 21///vacuole membrane protein 1",TRUE
+"224917_at",0.966641191718519,0.845082360746719,0.197699949589335,-5.92066439726777,0.185746511741719,"MIR21///VMP1","microRNA 21///vacuole membrane protein 1",TRUE
+"230710_at",0.896159990898752,0.579027777827203,-0.56309004612277,-5.78641905727567,-0.482145336970676,"MIR210HG","MIR210 host gene",TRUE
+"236480_at",0.971216837324271,0.8625810580372,0.175113230427927,-5.92475889077433,0.14017665299018,"MIR210HG","MIR210 host gene",TRUE
+"214696_at",0.835513930382091,0.41481318974328,0.831047257888156,-5.60878307061967,0.617424376951705,"MIR22///MIR22HG","microRNA 22///MIR22 host gene",TRUE
+"1555847_a_at",0.537477882922364,0.0435880554710153,2.14028364607892,-3.92529283624708,1.0616594768868,"MIR24-2///MIR23A///LOC284454","microRNA 24-2///microRNA 23a///uncharacterized LOC284454",TRUE
+"235317_at",0.971094654049796,0.861420900603541,0.176607707905401,-5.92450325249525,0.0535510461005977,"MIR24-2///MIR23A///LOC284454","microRNA 24-2///microRNA 23a///uncharacterized LOC284454",TRUE
+"1559506_x_at",0.60998004334651,0.0821562512885908,1.82089293476825,-4.44216205647729,2.81435216740994,"MIR2682///MIR137///MIR137HG","microRNA 2682///microRNA 137///MIR137 host gene",TRUE
+"1559504_at",0.748067267263424,0.240001059882435,1.20742297263891,-5.25350891411943,1.86008048891487,"MIR2682///MIR137///MIR137HG","microRNA 2682///microRNA 137///MIR137 host gene",TRUE
+"244322_at",0.852482434679576,0.458446109316572,0.754581185530821,-5.66609457367643,0.367088618928841,"MIR29B1///MIR29A","microRNA 29b-1///microRNA 29a",TRUE
+"228528_at",0.647754107214051,0.118905895157596,-1.62219605534417,-4.73331393154277,-1.17293984525,"MIR29C///MIR29B2","microRNA 29c///microRNA 29b-2",TRUE
+"231061_at",0.922630001580181,0.669119795567578,0.433112988641106,-5.8487275572256,0.140293247873017,"MIR302B","microRNA 302b",TRUE
+"1556755_s_at",0.643688366500038,0.114660036222299,1.64223405517015,-4.7051040583993,0.498516658199941,"MIR3150B///MIR3150A///LOC286149","microRNA 3150b///microRNA 3150a///uncharacterized LOC286149",TRUE
+"1561497_at",0.743494296770361,0.233906637379917,-1.22373565180074,-5.23548200662122,-0.924305839124185,"MIR3180-2///MIR3180-1///MIR3180-3","microRNA 3180-2///microRNA 3180-1///microRNA 3180-3",TRUE
+"230845_at",0.893600768892136,0.568690521201348,0.578606161079868,-5.77792445490485,0.500988217163139,"MIR3185///PRAC2","microRNA 3185///prostate cancer susceptibility candidate 2",TRUE
+"211692_s_at",0.755049574909504,0.24857941248332,-1.18498198396751,-5.27796459621349,-0.656766825024767,"MIR3190///MIR3191///BBC3","microRNA 3190///microRNA 3191///BCL2 binding component 3",TRUE
+"1554097_a_at",0.0925545494931958,0.00037072604186575,4.19422114029113,0.218701909229492,2.103938307307,"MIR31HG","MIR31 host gene",TRUE
+"235571_at",0.830635993561085,0.403906621609678,-0.850938074432123,-5.59302616824061,-0.519267081747135,"MIR34A","microRNA 34a",TRUE
+"1560207_at",0.841550580403629,0.433050901081621,0.798509808661682,-5.63380545958792,0.72446393771243,"MIR3610///RAD21-AS1","microRNA 3610///RAD21 antisense RNA 1",TRUE
+"200065_s_at",0.910888708415045,0.628171233722688,-0.491119668666521,-5.82288251220837,-0.133117270810486,"MIR3620///ARF1","microRNA 3620///ADP ribosylation factor 1",TRUE
+"244504_x_at",0.920119557710459,0.659713882346907,0.446297070147809,-5.8431326219836,0.164202475425623,"MIR3620///ARF1","microRNA 3620///ADP ribosylation factor 1",TRUE
+"208750_s_at",0.92014348012758,0.659928418586974,-0.445995470644634,-5.84326245169053,-0.166536238955489,"MIR3620///ARF1","microRNA 3620///ADP ribosylation factor 1",TRUE
+"200598_s_at",0.632216562924782,0.103424254461064,1.6984490023073,-4.62455663597774,0.704619373656675,"MIR3652///HSP90B1","microRNA 3652///heat shock protein 90 beta family member 1",TRUE
+"200599_s_at",0.716472449896956,0.192270264192417,1.34487883093007,-5.09515437550174,0.414572226204983,"MIR3652///HSP90B1","microRNA 3652///heat shock protein 90 beta family member 1",TRUE
+"211345_x_at",0.974982245454858,0.878413952731316,0.154757043657427,-5.92802517209858,0.0379046586774727,"MIR3654///EEF1G","microRNA 3654///eukaryotic translation elongation factor 1 gamma",TRUE
+"200689_x_at",0.986342822130003,0.935312611909366,0.0820895012497881,-5.93640184805818,0.0194091533974152,"MIR3654///EEF1G","microRNA 3654///eukaryotic translation elongation factor 1 gamma",TRUE
+"211927_x_at",0.996437521591612,0.982492171654384,-0.0221936151302792,-5.93944357746036,-0.00501979332928215,"MIR3654///EEF1G","microRNA 3654///eukaryotic translation elongation factor 1 gamma",TRUE
+"217959_s_at",0.775341201891078,0.29192819354604,-1.07961069793832,-5.38738857375126,-0.482030164938216,"MIR3656///TRAPPC4","microRNA 3656///trafficking protein particle complex 4",TRUE
+"234456_at",0.837368340567858,0.42114345103978,0.819653960524514,-5.61765146993887,0.650443184915831,"MIR3656///TRAPPC4","microRNA 3656///trafficking protein particle complex 4",TRUE
+"217958_at",0.87579870142401,0.523719585586979,-0.647880701932983,-5.73728127169004,-0.234438050859032,"MIR3656///TRAPPC4","microRNA 3656///trafficking protein particle complex 4",TRUE
+"225722_at",0.713633547141264,0.188788214464586,-1.35590676656063,-5.08182533832649,-0.375166745273077,"MIR3658///UCK2","microRNA 3658///uridine-cytidine kinase 2",TRUE
+"209825_s_at",0.853460708803218,0.461968923018327,-0.748604748078578,-5.6703540375235,-0.230221303865516,"MIR3658///UCK2","microRNA 3658///uridine-cytidine kinase 2",TRUE
+"1561328_at",0.731574335156004,0.215327680231562,1.27554632768149,-5.17684729503798,1.14968355306979,"MIR3663HG","MIR3663 host gene",TRUE
+"239130_at",0.83030603167465,0.402624195612667,0.853299294233213,-5.59113259663561,0.662854783431801,"MIR3671///MIR101-1","microRNA 3671///microRNA 101-1",TRUE
+"237880_at",0.204217046368216,0.00230456182184159,3.44270261017913,-1.39188631816095,1.98577462278265,"MIR3681HG","MIR3681 host gene",TRUE
+"237321_at",0.930827859648584,0.69380508373635,0.398872876573896,-5.86248764488485,0.143839560396957,"MIR3681HG","MIR3681 host gene",TRUE
+"233590_at",0.937113154905832,0.719370339444473,-0.363916037315685,-5.87538438512896,-0.185518411785328,"MIR3681HG","MIR3681 host gene",TRUE
+"229926_at",0.656107731346623,0.124430177716002,1.59700282982552,-4.7684013629934,0.901142788086358,"MIR3682","microRNA 3682",TRUE
+"217544_at",0.932018790587499,0.699463661925463,0.391093421233507,-5.86545854282084,0.273680440567547,"MIR3916","microRNA 3916",TRUE
+"217714_x_at",0.822452640841017,0.387324340399681,0.881850965624353,-5.56784951602972,0.243415243278035,"MIR3917///STMN1","microRNA 3917///stathmin 1",TRUE
+"224448_s_at",0.84932977991296,0.450290926207791,-0.768523065733494,-5.65603355219715,-0.311936977693183,"MIR3934///UQCC2","microRNA 3934///ubiquinol-cytochrome c reductase complex assembly factor 2",TRUE
+"228192_at",0.974670398319743,0.87618389351317,0.157619958076671,-5.92759009898346,0.0899602699018054,"MIR3934///UQCC2","microRNA 3934///ubiquinol-cytochrome c reductase complex assembly factor 2",TRUE
+"1569095_at",0.465776708318531,0.0241405923867389,2.42044406402633,-3.42944816128896,1.17669602355627,"MIR3945HG","MIR3945 host gene",TRUE
+"1559777_at",0.741260241503758,0.231730341053128,1.22963877171887,-5.22890701886482,0.41337375467716,"MIR3945HG","MIR3945 host gene",TRUE
+"233610_at",0.565993041605217,0.056904686780135,2.00873777281635,-4.1449601598561,0.929564720452295,"MIR3976HG","MIR3976 host gene",TRUE
+"228235_at",0.69410086222651,0.163545094123352,-1.44108408637755,-4.9758425045178,-1.3041742619609,"MIR424///MIR503HG","microRNA 424///MIR503 host gene",TRUE
+"229784_at",0.998709719538178,0.994289379443872,-0.00723845332709254,-5.93965796100799,-0.00392826371437671,"MIR424///MIR503HG","microRNA 424///MIR503 host gene",TRUE
+"241817_at",0.902229953331547,0.600850640783338,0.530781468850165,-5.80338749111665,0.34065286750364,"MIR4271///C3orf62","microRNA 4271///chromosome 3 open reading frame 62",TRUE
+"202681_at",0.943631120237335,0.747920512238728,-0.325414379566276,-5.88823737132067,-0.116672465639699,"MIR4271///C3orf62///USP4","microRNA 4271///chromosome 3 open reading frame 62///ubiquitin specific peptidase 4",TRUE
+"1561289_at",0.790817398514927,0.320624428476695,1.01593929741728,-5.44909732616268,0.7336705492796,"MIR4290HG","MIR4290 host gene",TRUE
+"1561963_at",0.933283911955776,0.704755242303029,0.383840689112171,-5.86817635062617,0.283328388145162,"MIR4296","microRNA 4296",TRUE
+"1557022_at",0.75193462989549,0.245107873676037,1.19399245856839,-5.26819315176071,0.973460690648885,"MIR4300HG","MIR4300 host gene",TRUE
+"244608_at",0.5932897315606,0.0699143253853671,1.90446438570525,-4.31244142755605,1.67490023126382,"MIR4307HG","MIR4307 host gene",TRUE
+"1562383_at",0.358427723880268,0.00990125048165225,2.82124391518667,-2.66523987365254,1.98801682039385,"MIR4313","microRNA 4313",TRUE
+"206516_at",0.895370220688938,0.573828857227826,-0.570875878146592,-5.78218451702473,-0.580353921885805,"MIR4321///AMH","microRNA 4321///anti-Mullerian hormone",TRUE
+"1562876_s_at",0.705853136697393,0.1782222689,1.39038352837585,-5.03957016555668,1.69209852109963,"MIR4435-2HG","MIR4435-2 host gene",TRUE
+"232918_at",0.837067957688307,0.419250780471651,0.82304905706602,-5.61502075922142,0.902149960304087,"MIR4435-2HG","MIR4435-2 host gene",TRUE
+"231954_at",0.51470556386048,0.0352102691067726,-2.24313679675196,-3.74746014369741,-0.818860667450735,"MIR4453///DKFZP434I0714","microRNA 4453///uncharacterized protein DKFZP434I0714",TRUE
+"237974_at",0.807944276806637,0.349584164780766,-0.955602084416805,-5.50443562028709,-1.27660076306078,"MIR4454///ABHD12B","microRNA 4454///abhydrolase domain containing 12B",TRUE
+"1564357_at",0.843850838418098,0.439942622600303,-0.786436375309053,-5.64285144556628,-0.831908552509983,"MIR4454///ABHD12B","microRNA 4454///abhydrolase domain containing 12B",TRUE
+"231381_at",0.939452234779565,0.72889477678828,-0.351012263684686,-5.8798501521883,-0.333644570273744,"MIR4454///ESRG","microRNA 4454///embryonic stem cell related (non-protein coding)",TRUE
+"229347_at",0.8751553586947,0.522051980316921,0.65050976890983,-5.73565179559702,0.815741669201058,"MIR4458///MIR4458HG","microRNA 4458///MIR4458 host gene",TRUE
+"236591_at",0.885190678056007,0.546258774688316,0.612782809163646,-5.75842646730728,0.52766808882155,"MIR4458///MIR4458HG","microRNA 4458///MIR4458 host gene",TRUE
+"225680_at",0.94943075115007,0.771361328775932,-0.29417650391025,-5.8976208056944,-0.141372806135056,"MIR4467///LRWD1","microRNA 4467///leucine rich repeats and WD repeat domain containing 1",TRUE
+"232848_at",0.945819521856653,0.755278717713445,0.315574506833895,-5.89129425758433,0.259237062878269,"MIR4500HG","MIR4500 host gene",TRUE
+"204537_s_at",0.618085483489405,0.0889736231717102,1.77894336407985,-4.50569938880974,2.95471669850598,"MIR452///MIR224///GABRE","microRNA 452///microRNA 224///gamma-aminobutyric acid type A receptor epsilon subunit",TRUE
+"207169_x_at",0.780216511409289,0.301605966282854,1.05766021434339,-5.40904278772907,0.582244007480702,"MIR4640///DDR1","microRNA 4640///discoidin domain receptor tyrosine kinase 1",TRUE
+"208779_x_at",0.8158712121142,0.366787643233051,0.921357801566898,-5.53446333528106,0.51105706343187,"MIR4640///DDR1","microRNA 4640///discoidin domain receptor tyrosine kinase 1",TRUE
+"210749_x_at",0.822600785740588,0.387685816026298,0.881168049544109,-5.56841472095744,0.420614076089041,"MIR4640///DDR1","microRNA 4640///discoidin domain receptor tyrosine kinase 1",TRUE
+"1007_s_at",0.822850703882235,0.38827080316737,0.880063743691651,-5.56932782318628,0.400798654831036,"MIR4640///DDR1","microRNA 4640///discoidin domain receptor tyrosine kinase 1",TRUE
+"224716_at",0.878703929399706,0.531738421730566,-0.635302027691065,-5.74498969447548,-0.21847275837616,"MIR4647///SLC35B2","microRNA 4647///solute carrier family 35 member B2",TRUE
+"209912_s_at",0.744307803443383,0.235178627983663,1.22030466957394,-5.23929092272125,0.539710459766737,"MIR4656///AP5Z1","microRNA 4656///adaptor related protein complex 5 zeta 1 subunit",TRUE
+"209913_x_at",0.978928101156583,0.897234755558795,0.130645403961405,-5.93137359711806,0.0682833094186295,"MIR4656///AP5Z1","microRNA 4656///adaptor related protein complex 5 zeta 1 subunit",TRUE
+"225120_at",0.581406183553129,0.0638999581824983,-1.95032982479749,-4.23952454594483,-0.663679096167945,"MIR4657///PURB","microRNA 4657///purine rich element binding protein B",TRUE
+"226762_at",0.775351898377291,0.292252957625001,-1.07886570644548,-5.38813002927855,-0.435942269555513,"MIR4657///PURB","microRNA 4657///purine rich element binding protein B",TRUE
+"227718_at",0.86481525165637,0.492461608304993,0.697961765165781,-5.70515564411129,0.321609581216126,"MIR4657///PURB","microRNA 4657///purine rich element binding protein B",TRUE
+"235711_at",0.966971067428863,0.845929458183629,0.196604214955398,-5.9208744406701,0.0900236209911149,"MIR4657///PURB","microRNA 4657///purine rich element binding protein B",TRUE
+"202730_s_at",0.755719147268412,0.250022148095553,-1.18126499688617,-5.28197668973388,-1.05664815820691,"MIR4680///PDCD4","microRNA 4680///programmed cell death 4 (neoplastic transformation inhibitor)",TRUE
+"202731_at",0.76912869907427,0.27509306472931,-1.11907702913856,-5.3474588274799,-1.04858152720031,"MIR4680///PDCD4","microRNA 4680///programmed cell death 4 (neoplastic transformation inhibitor)",TRUE
+"212594_at",0.816800680706682,0.36876783258141,-0.917485731671127,-5.53779520312308,-1.06075487091342,"MIR4680///PDCD4","microRNA 4680///programmed cell death 4 (neoplastic transformation inhibitor)",TRUE
+"212593_s_at",0.819162667476514,0.375531544299938,-0.904363108534476,-5.5489907793705,-0.904294209144117,"MIR4680///PDCD4","microRNA 4680///programmed cell death 4 (neoplastic transformation inhibitor)",TRUE
+"216587_s_at",0.623852759019384,0.0954989901305119,1.74130740374493,-4.56177999461213,1.25791028878288,"MIR4683///FZD8","microRNA 4683///frizzled class receptor 8",TRUE
+"224325_at",0.784925710185113,0.310176996413596,1.03863481433776,-5.42748836348159,1.2249544389141,"MIR4683///FZD8","microRNA 4683///frizzled class receptor 8",TRUE
+"227405_s_at",0.92260505525875,0.669034206326455,0.433232602788293,-5.84867753687135,0.325732885976754,"MIR4683///FZD8","microRNA 4683///frizzled class receptor 8",TRUE
+"232123_at",0.827832423755003,0.397029010028169,-0.863658085797223,-5.5827676637458,-0.687282250948584,"MIR4697///MIR4697HG","microRNA 4697///MIR4697 host gene",TRUE
+"229734_at",0.857022970548279,0.47165653742657,-0.732308311875308,-5.6818054938455,-0.301101574276175,"MIR4697///MIR4697HG","microRNA 4697///MIR4697 host gene",TRUE
+"218383_at",0.848376789225697,0.448555971270522,-0.771508727671271,-5.65385635599057,-0.286327185158598,"MIR4707///HAUS4","microRNA 4707///HAUS augmin like complex subunit 4",TRUE
+"229182_at",0.622434989367596,0.0924269899326329,-1.75874125665129,-4.53591188004713,-0.626481690322276,"MIR4723///TMEM199","microRNA 4723///transmembrane protein 199",TRUE
+"225374_at",0.839045421044582,0.424834598773878,-0.813060143354388,-5.62273160531973,-0.205648489650738,"MIR4723///TMEM199","microRNA 4723///transmembrane protein 199",TRUE
+"225375_at",0.949613960042259,0.772236104353209,-0.293016712505115,-5.89795113346618,-0.109737175568736,"MIR4723///TMEM199","microRNA 4723///transmembrane protein 199",TRUE
+"211997_x_at",0.886023097762234,0.548584999156064,0.609204918248967,-5.76051829518362,0.192999634117319,"MIR4738///H3F3B///H3F3A","microRNA 4738///H3 histone, family 3B///H3 histone, family 3A",TRUE
+"211999_at",0.894205199149904,0.570521818441231,0.575847036247173,-5.77945134294222,0.175379931921505,"MIR4738///H3F3B///H3F3A","microRNA 4738///H3 histone, family 3B///H3 histone, family 3A",TRUE
+"209069_s_at",0.92777930247318,0.683300028675744,0.413382431819357,-5.8567926906042,0.145290012921613,"MIR4738///H3F3B///H3F3A","microRNA 4738///H3 histone, family 3B///H3 histone, family 3A",TRUE
+"211998_at",0.93178677872825,0.698841627329786,0.391947389408536,-5.86513523738599,0.212578106317917,"MIR4738///H3F3B///H3F3A","microRNA 4738///H3 histone, family 3B///H3 histone, family 3A",TRUE
+"202189_x_at",0.878218253751206,0.53017856394854,0.637740753648894,-5.74350655413371,0.165450968715128,"MIR4745///PTBP1","microRNA 4745///polypyrimidine tract binding protein 1",TRUE
+"216306_x_at",0.898405288322584,0.58766440900216,0.550232963899307,-5.79328822099904,0.135303083073973,"MIR4745///PTBP1","microRNA 4745///polypyrimidine tract binding protein 1",TRUE
+"211271_x_at",0.906222238025079,0.612833306424129,0.513283566400758,-5.81217013878981,0.13697850336048,"MIR4745///PTBP1","microRNA 4745///polypyrimidine tract binding protein 1",TRUE
+"212015_x_at",0.932830928398943,0.703653974585367,0.385348366455088,-5.8676155090223,0.10626058333202,"MIR4745///PTBP1","microRNA 4745///polypyrimidine tract binding protein 1",TRUE
+"212016_s_at",0.975356626088054,0.880698844424945,0.151825108820808,-5.92846248748832,0.053009052813124,"MIR4745///PTBP1","microRNA 4745///polypyrimidine tract binding protein 1",TRUE
+"223012_at",0.585036027492332,0.0654680992379998,-1.93801662012505,-4.25921746506253,-0.556844070576567,"MIR4746///UBXN6","microRNA 4746///UBX domain protein 6",TRUE
+"220757_s_at",0.85334340854827,0.461262452639068,-0.749801082343262,-5.66950396622291,-0.209027692563042,"MIR4746///UBXN6","microRNA 4746///UBX domain protein 6",TRUE
+"224096_at",0.791136800521389,0.32121528733012,1.01467132137369,-5.45029187187864,0.760744711601625,"MIR4755","microRNA 4755",TRUE
+"213166_x_at",0.598790786356002,0.0757906563537518,-1.86288017624974,-4.37750414245753,-0.513737160745476,"MIR4784///MZT2A///MZT2B","microRNA 4784///mitotic spindle organizing protein 2A///mitotic spindle organizing protein 2B",TRUE
+"212347_x_at",0.194294573776651,0.00202556757298017,-3.49643647512992,-1.27840093397426,-1.5180922703724,"MIR4800///MXD4","microRNA 4800///MAX dimerization protein 4",TRUE
+"210778_s_at",0.592111379991983,0.0692989615101728,-1.90899430459638,-4.30529325517512,-1.11461979068202,"MIR4800///MXD4","microRNA 4800///MAX dimerization protein 4",TRUE
+"212346_s_at",0.620912785033482,0.0905992795257639,-1.76935090313538,-4.5200765834696,-0.805215912036228,"MIR4800///MXD4","microRNA 4800///MAX dimerization protein 4",TRUE
+"233934_at",0.818768038148976,0.372447899080489,-0.91032625787697,-5.54392176256021,-0.618541173985736,"MIR490///LOC349160","microRNA 490///uncharacterized LOC349160",TRUE
+"217350_at",0.852503125709186,0.458504013070038,0.75448273032544,-5.66616500338084,0.488532115643666,"MIR492///KRT19P2","microRNA 492///keratin 19 pseudogene 2",TRUE
+"230353_at",0.834950917495714,0.413756930198973,0.83295898046083,-5.60728378801044,0.527035620833853,"MIR497HG///MIR497///MIR195///LOC284112","mir-497-195 cluster host gene///microRNA 497///microRNA 195///uncharacterized LOC284112",TRUE
+"227488_at",0.954387719376857,0.790203967654934,-0.269282665236935,-5.90442658244415,-0.263904485705389,"MIR503///MIR424///MIR503HG","microRNA 503///microRNA 424///MIR503 host gene",TRUE
+"200033_at",0.784124594631274,0.307210980509213,-1.04517595638304,-5.42118052748824,-0.220584812004319,"MIR5047///MIR3064///DDX5","microRNA 5047///microRNA 3064///DEAD-box helicase 5",TRUE
+"238213_at",0.979347742195592,0.900443050934792,-0.126543507474872,-5.93188702100856,-0.0494204175069717,"MIR5188","microRNA 5188",TRUE
+"203281_s_at",0.712975827977365,0.187420417640005,1.36028253949888,-5.07651130273955,1.60125403766884,"MIR5193///UBA7","microRNA 5193///ubiquitin like modifier activating enzyme 7",TRUE
+"1294_at",0.777547149102231,0.296541621455505,1.06908296645693,-5.39782388635152,0.48632759614053,"MIR5193///UBA7","microRNA 5193///ubiquitin like modifier activating enzyme 7",TRUE
+"206163_at",0.610455440146151,0.0830848638378005,1.81500575080787,-4.45114346697876,1.67649794314668,"MIR548F5///MAB21L1","microRNA 548f-5///mab-21 like 1",TRUE
+"1561609_at",0.590570903980459,0.0682788026692035,1.91658242959077,-4.29329282472307,1.0789327393348,"MIR548XHG","MIR548X host gene",TRUE
+"221422_s_at",0.774230543658252,0.289688354910023,-1.08476505368128,-5.3822461690997,-0.430405289227611,"MIR600///MIR600HG","microRNA 600///MIR600 host gene",TRUE
+"223522_at",0.94632739401154,0.757477312693572,-0.3126406045344,-5.89218772406499,-0.106163885078974,"MIR600///MIR600HG","microRNA 600///MIR600 host gene",TRUE
+"212700_x_at",0.812302873476553,0.359389930358371,0.935948032586247,-5.52179265873144,0.267815755591529,"MIR6080///MIR4315-1///MIR4315-2///PLEKHM1P1///PLEKHM1","microRNA 6080///microRNA 4315-1///microRNA 4315-2///pleckstrin homology and RUN domain containing M1 pseudogene 1///pleckstrin homology and RUN domain containing M1",TRUE
+"220983_s_at",0.62110896023334,0.0912800997800633,-1.76537751833308,-4.52601520456876,-1.71918362398926,"MIR612///NEAT1","microRNA 612///nuclear paraspeckle assembly transcript 1 (non-protein coding)",TRUE
+"225239_at",0.701308253942732,0.173010712008131,-1.40799020134057,-5.01765241171968,-1.2534860866998,"MIR612///NEAT1","microRNA 612///nuclear paraspeckle assembly transcript 1 (non-protein coding)",TRUE
+"238320_at",0.742608345161152,0.23294399897613,-1.22634161350265,-5.23258281450496,-1.11106013701051,"MIR612///NEAT1","microRNA 612///nuclear paraspeckle assembly transcript 1 (non-protein coding)",TRUE
+"227062_at",0.78969417320323,0.317582869677565,-1.02249242273845,-5.44290220262251,-1.19829584533907,"MIR612///NEAT1","microRNA 612///nuclear paraspeckle assembly transcript 1 (non-protein coding)",TRUE
+"239269_at",0.804966190665093,0.344100042217184,-0.966757393322318,-5.49443720846677,-0.416277387894461,"MIR612///NEAT1","microRNA 612///nuclear paraspeckle assembly transcript 1 (non-protein coding)",TRUE
+"234989_at",0.8920930097751,0.564187534101656,-0.585409980934813,-5.77412906210425,-0.633521271526577,"MIR612///NEAT1","microRNA 612///nuclear paraspeckle assembly transcript 1 (non-protein coding)",TRUE
+"224565_at",0.903021267024792,0.602995642430302,0.527636998921405,-5.80498690987458,0.28903091163205,"MIR612///NEAT1","microRNA 612///nuclear paraspeckle assembly transcript 1 (non-protein coding)",TRUE
+"214657_s_at",0.95804391060575,0.810837200171384,0.24222058979399,-5.91114742418948,0.192670528283102,"MIR612///NEAT1","microRNA 612///nuclear paraspeckle assembly transcript 1 (non-protein coding)",TRUE
+"224566_at",0.97589003385521,0.884613293044495,0.146805303973495,-5.92919184342093,0.0972663401393792,"MIR612///NEAT1","microRNA 612///nuclear paraspeckle assembly transcript 1 (non-protein coding)",TRUE
+"244028_at",0.296964617886988,0.00539677065359273,-3.08380770846042,-2.13760390228656,-1.40863971237493,"MIR6125///USP15","microRNA 6125///ubiquitin specific peptidase 15",TRUE
+"231990_at",0.556381379241158,0.0518943561528133,-2.05463295745941,-4.06935077601414,-0.730086050317289,"MIR6125///USP15","microRNA 6125///ubiquitin specific peptidase 15",TRUE
+"210681_s_at",0.731054546207485,0.213613852427663,-1.28049605534358,-5.1711367843464,-0.457094281419067,"MIR6125///USP15","microRNA 6125///ubiquitin specific peptidase 15",TRUE
+"209475_at",0.93763407082406,0.724160219688197,-0.357418943852495,-5.87765281678561,-0.11877444174273,"MIR6125///USP15","microRNA 6125///ubiquitin specific peptidase 15",TRUE
+"207524_at",0.626839388794963,0.0973696440610493,1.73092505487676,-4.57709447316881,0.693642178681028,"MIR6132///ST7-OT3///ST7","microRNA 6132///ST7 overlapping transcript 3///suppression of tumorigenicity 7",TRUE
+"207871_s_at",0.996118448346386,0.980567306895453,0.0246341401136792,-5.93938791526299,0.0110501226756377,"MIR6132///ST7-OT3///ST7","microRNA 6132///ST7 overlapping transcript 3///suppression of tumorigenicity 7",TRUE
+"216808_at",0.821990323055816,0.385357101987358,-0.88557486625898,-5.56476034462649,-0.578794620701203,"MIR622","microRNA 622",TRUE
+"219396_s_at",0.733329462250576,0.217725416748305,1.26867204089856,-5.18474685335671,1.06522675724493,"MIR631///NEIL1","microRNA 631///nei like DNA glycosylase 1",TRUE
+"241477_at",0.740610299769501,0.230296963894326,1.23354976581074,-5.2245358551688,0.713878715381651,"MIR631///NEIL1","microRNA 631///nei like DNA glycosylase 1",TRUE
+"200753_x_at",0.951318915881544,0.777166943065429,-0.286486945637784,-5.89978676113501,-0.0674195232802166,"MIR636///SRSF2","microRNA 636///serine and arginine rich splicing factor 2",TRUE
+"200754_x_at",0.95915232180739,0.814843850633123,-0.236987566198735,-5.91236546467994,-0.0558660820462347,"MIR636///SRSF2","microRNA 636///serine and arginine rich splicing factor 2",TRUE
+"214882_s_at",0.974539404786176,0.875721911230903,-0.158213211422666,-5.92749894797983,-0.0406015978501983,"MIR636///SRSF2","microRNA 636///serine and arginine rich splicing factor 2",TRUE
+"203890_s_at",0.641326159307468,0.111800330510327,-1.65608461901176,-4.68544987024283,-0.598300259397487,"MIR637///DAPK3","microRNA 637///death associated protein kinase 3",TRUE
+"203891_s_at",0.792436690618566,0.324013168578414,-1.00868909591736,-5.45590943990623,-0.251741194153569,"MIR637///DAPK3","microRNA 637///death associated protein kinase 3",TRUE
+"236846_at",0.851733415458562,0.456415952538267,-0.758037838746884,-5.66361635302919,-0.501193140498546,"MIR646HG","MIR646 host gene",TRUE
+"217730_at",0.769646142132413,0.277086687914667,1.11431348776436,-5.35234583310847,1.05388444303262,"MIR6513///TMBIM1","microRNA 6513///transmembrane BAX inhibitor motif containing 1",TRUE
+"221621_at",0.837368340567858,0.421036367934626,0.81984579165018,-5.61750310000906,0.325765334435824,"MIR6516///SCARNA16///SNHG20","microRNA 6516///small Cajal body-specific RNA 16///small nucleolar RNA host gene 20",TRUE
+"237670_at",0.776983560547865,0.295903402018561,1.07053234451784,-5.39639265999682,0.930086776108287,"MIR663AHG","MIR663A host gene",TRUE
+"201478_s_at",0.909441542080538,0.623688693042819,-0.497570869307879,-5.81981209875661,-0.19319155775796,"MIR664B///SNORA56///DKC1","microRNA 664b///small nucleolar RNA, H/ACA box 56///dyskerin pseudouridine synthase 1",TRUE
+"201479_at",0.96635324070119,0.843243924687639,-0.200078851345479,-5.9202043779912,-0.0720527548052541,"MIR664B///SNORA56///DKC1","microRNA 664b///small nucleolar RNA, H/ACA box 56///dyskerin pseudouridine synthase 1",TRUE
+"216212_s_at",0.974536463688956,0.875432699084016,-0.158584632023552,-5.92744170680542,-0.0683608801774014,"MIR664B///SNORA56///DKC1","microRNA 664b///small nucleolar RNA, H/ACA box 56///dyskerin pseudouridine synthase 1",TRUE
+"244136_at",0.860085676417428,0.478685761917947,-0.72060705751863,-5.68988030095472,-0.438920907943429,"MIR670HG","MIR670 host gene",TRUE
+"216019_x_at",0.73223722457785,0.216416830562802,1.27241648452227,-5.18044846172319,0.487977936464726,"MIR6716///PHLDB1","microRNA 6716///pleckstrin homology like domain family B member 1",TRUE
+"212134_at",0.843850838418098,0.439934174037848,0.786451104662015,-5.64284048868927,0.343130512089788,"MIR6716///PHLDB1","microRNA 6716///pleckstrin homology like domain family B member 1",TRUE
+"217994_x_at",0.857287594027564,0.472336150387047,0.731172535319984,-5.68259468523636,0.234164039556338,"MIR6727///CPSF3L","microRNA 6727///cleavage and polyadenylation specific factor 3-like",TRUE
+"233563_s_at",0.895690630367785,0.576278857046729,0.56720237985914,-5.78418947467248,0.17560948075123,"MIR6727///CPSF3L","microRNA 6727///cleavage and polyadenylation specific factor 3-like",TRUE
+"233625_x_at",0.903989791603451,0.60602119552167,0.52321081003104,-5.80722258986125,0.163974720874119,"MIR6727///CPSF3L","microRNA 6727///cleavage and polyadenylation specific factor 3-like",TRUE
+"218810_at",0.68041487556515,0.148095480889457,1.49858180052865,-4.90132716158301,0.561862306485025,"MIR6732///ZC3H12A","microRNA 6732///zinc finger CCCH-type containing 12A",TRUE
+"201323_at",0.779854829728531,0.301183720692606,1.0586073521026,-5.4081166599996,0.546552727051843,"MIR6733///EBNA1BP2","microRNA 6733///EBNA1 binding protein 2",TRUE
+"218028_at",0.943824539742785,0.748281896386523,-0.324930355093919,-5.88838991274673,-0.116308532308414,"MIR6734///ELOVL1","microRNA 6734///ELOVL fatty acid elongase 1",TRUE
+"57163_at",0.998870448604467,0.996362191226795,-0.00461105162893556,-5.93967312491694,-0.00159166217792794,"MIR6734///ELOVL1","microRNA 6734///ELOVL fatty acid elongase 1",TRUE
+"224855_at",0.923221265004765,0.670663048988738,0.43095733402671,-5.84962668565561,0.141104067626513,"MIR6741///PYCR2","microRNA 6741///pyrroline-5-carboxylate reductase family member 2",TRUE
+"231715_s_at",0.928246500493356,0.684826634885867,0.411268347957269,-5.85763492213454,0.137037726565273,"MIR6741///PYCR2","microRNA 6741///pyrroline-5-carboxylate reductase family member 2",TRUE
+"221647_s_at",0.778594464477313,0.298948945455368,-1.06363598028293,-5.40318713336416,-1.73632271895419,"MIR6743///RIC8A","microRNA 6743///RIC8 guanine nucleotide exchange factor A",TRUE
+"228089_x_at",0.589729941648868,0.0678963642650664,-1.91945275171698,-4.28874487574941,-0.731761041560098,"MIR6748///TMEM179B","microRNA 6748///transmembrane protein 179B",TRUE
+"224646_x_at",0.721907781985393,0.198115016339376,1.32671555016866,-5.11690846457895,1.83126446126559,"MIR675///H19","microRNA 675///H19, imprinted maternally expressed transcript (non-protein coding)",TRUE
+"224997_x_at",0.732963666545614,0.217186592809556,1.270211753482,-5.18298066794118,0.905376159753031,"MIR675///H19","microRNA 675///H19, imprinted maternally expressed transcript (non-protein coding)",TRUE
+"225090_at",0.84421131646729,0.440860882485219,-0.784836499534884,-5.64404041095808,-0.29691639058789,"MIR6751///SYVN1","microRNA 6751///synoviolin 1",TRUE
+"210869_s_at",0.419416770470054,0.0173213181110449,2.57230182089943,-3.1466767124399,4.31154541940388,"MIR6756///MCAM","microRNA 6756///melanoma cell adhesion molecule",TRUE
+"211042_x_at",0.461822652528876,0.0232216630402532,2.43838034795185,-3.39652542307029,1.08467640347478,"MIR6756///MCAM","microRNA 6756///melanoma cell adhesion molecule",TRUE
+"211340_s_at",0.483035731662347,0.0276083522898004,2.35800557024975,-3.54300721887018,2.54736237489662,"MIR6756///MCAM","microRNA 6756///melanoma cell adhesion molecule",TRUE
+"209086_x_at",0.485183483700012,0.0279651563256623,2.35199812766233,-3.55384537724122,1.66178349810544,"MIR6756///MCAM","microRNA 6756///melanoma cell adhesion molecule",TRUE
+"213672_at",0.603853962695872,0.0784154208530533,-1.84520920887653,-4.40484455612599,-0.713208312170282,"MIR6758///MARS","microRNA 6758///methionyl-tRNA synthetase",TRUE
+"213671_s_at",0.714090776972967,0.189170385252427,-1.35468861673985,-5.08330214116593,-0.386791830912477,"MIR6758///MARS","microRNA 6758///methionyl-tRNA synthetase",TRUE
+"201475_x_at",0.789661545166663,0.317025683735593,-1.02369765202693,-5.44175889697074,-0.286026918820296,"MIR6758///MARS","microRNA 6758///methionyl-tRNA synthetase",TRUE
+"219395_at",0.843121215318579,0.437513066111914,-0.790679277749576,-5.63968724467871,-0.540272747029194,"MIR6773///ESRP2","microRNA 6773///epithelial splicing regulatory protein 2",TRUE
+"209980_s_at",0.835513930382091,0.414901358997363,0.83088781969524,-5.60890796564583,0.497095302476152,"MIR6778///SHMT1","microRNA 6778///serine hydroxymethyltransferase 1",TRUE
+"224954_at",0.87229297572367,0.515398712039381,0.661045316162134,-5.72905842448986,0.295451693662612,"MIR6778///SHMT1","microRNA 6778///serine hydroxymethyltransferase 1",TRUE
+"222210_at",0.627021415091472,0.0976419350789219,1.72942804625499,-4.57929702166521,0.890913158844433,"MIR6785///TMEM94","microRNA 6785///transmembrane protein 94",TRUE
+"202650_s_at",0.801547748171611,0.3384019510022,-0.978477192354645,-5.48381874799541,-0.430754566417667,"MIR6785///TMEM94","microRNA 6785///transmembrane protein 94",TRUE
+"202855_s_at",0.606900628956089,0.0803827050698268,1.8322988876195,-4.42470181926685,2.48559061675005,"MIR6787///SLC16A3","microRNA 6787///solute carrier family 16 member 3",TRUE
+"202856_s_at",0.609532363331105,0.0817925176907815,1.82321464084656,-4.43861433715266,2.33877965512193,"MIR6787///SLC16A3","microRNA 6787///solute carrier family 16 member 3",TRUE
+"217691_x_at",0.689913893405055,0.159118486984713,1.45709190031442,-4.95533420175869,0.674293030259186,"MIR6787///SLC16A3","microRNA 6787///solute carrier family 16 member 3",TRUE
+"218290_at",0.497725944448536,0.0306014151472912,-2.30967789127883,-3.62974791004721,-0.617727012093958,"MIR6789///PLEKHJ1","microRNA 6789///pleckstrin homology domain containing J1",TRUE
+"225058_at",0.78638420006208,0.311835314888815,-1.03499684771908,-5.4309811397935,-0.363896229323386,"MIR6791///GPR108","microRNA 6791///G protein-coupled receptor 108",TRUE
+"1553993_s_at",0.942303845415102,0.740181029488301,-0.335799627084509,-5.88491030904615,-0.112539056576814,"MIR6800///MED25","microRNA 6800///mediator complex subunit 25",TRUE
+"200003_s_at",0.968153683624521,0.850381572974558,0.19084934360665,-5.9219585058104,0.0450855867541264,"MIR6805///RPL28","microRNA 6805///ribosomal protein L28",TRUE
+"213223_at",0.988224361618126,0.943895452985852,-0.0711769969711011,-5.93721623983583,-0.0288450974685546,"MIR6805///RPL28","microRNA 6805///ribosomal protein L28",TRUE
+"221572_s_at",0.697172073261335,0.167513316465912,-1.42702794766087,-4.99369789394097,-0.567118965952831,"MIR6824///SLC26A6","microRNA 6824///solute carrier family 26 member 6",TRUE
+"204650_s_at",0.796378050779806,0.328898978597491,-0.998328219141919,-5.46556750427054,-0.374766518628331,"MIR6831///APBB3","microRNA 6831///amyloid beta precursor protein binding family B member 3",TRUE
+"222019_at",0.712055111306836,0.186184465165716,-1.36425824635493,-5.0716707295845,-0.634111959782661,"MIR6834///PFDN6","microRNA 6834///prefoldin subunit 6",TRUE
+"242048_at",0.867692227847244,0.500483077725185,0.684943144282611,-5.71372669024688,0.177802274067592,"MIR6834///PFDN6","microRNA 6834///prefoldin subunit 6",TRUE
+"222029_x_at",0.96287357728432,0.831606221545269,0.215165869481383,-5.91715935845329,0.0798719757843855,"MIR6834///PFDN6","microRNA 6834///prefoldin subunit 6",TRUE
+"233588_x_at",0.980609801384766,0.909370987830119,0.115140352851325,-5.93322840049147,0.0427871664157262,"MIR6834///PFDN6","microRNA 6834///prefoldin subunit 6",TRUE
+"228231_at",0.840951887142661,0.430620439610685,0.802795947175059,-5.63056291426048,0.371638361992709,"MIR6836///SNX8","microRNA 6836///sorting nexin 8",TRUE
+"223241_at",0.94895689004559,0.767854163906675,0.298830516324439,-5.89628225240994,0.110358289147177,"MIR6836///SNX8","microRNA 6836///sorting nexin 8",TRUE
+"222429_at",0.666643938027574,0.133437300885551,1.5578560644518,-4.82207123562795,0.429799828909617,"MIR6837///DBNL","microRNA 6837///drebrin like",TRUE
+"220954_s_at",0.93759536651083,0.723238858392213,0.358667471620739,-5.8772200312796,0.130811894489057,"MIR6840///STAG3L5P-PVRIG2P-PILRB///PILRB","microRNA 6840///STAG3L5P-PVRIG2P-PILRB readthrough///paired immunoglobin-like type 2 receptor beta",TRUE
+"225321_s_at",0.985361089461736,0.927257336332487,0.0923405159062752,-5.93553125823332,0.0342800605306142,"MIR6840///STAG3L5P-PVRIG2P-PILRB///PILRB","microRNA 6840///STAG3L5P-PVRIG2P-PILRB readthrough///paired immunoglobin-like type 2 receptor beta",TRUE
+"225949_at",0.856249724432132,0.469711897300282,0.735563556073545,-5.67953715353202,0.381068564281049,"MIR6845///NRBP2","microRNA 6845///nuclear receptor binding protein 2",TRUE
+"33132_at",0.512957854428756,0.0343848291994767,2.25444496988356,-3.72759962405767,0.809968638162477,"MIR6849///MIR1234///MIR939///CPSF1","microRNA 6849///microRNA 1234///microRNA 939///cleavage and polyadenylation specific factor 1",TRUE
+"201639_s_at",0.565956563686213,0.056811773273371,2.00955553117534,-4.14362287668054,0.884219817061414,"MIR6849///MIR1234///MIR939///CPSF1","microRNA 6849///microRNA 1234///microRNA 939///cleavage and polyadenylation specific factor 1",TRUE
+"226340_x_at",0.863559206655094,0.488589473822349,0.704289554680677,-5.70093402773837,0.18888585846042,"MIR6859-1///MIR6859-2///LOC101930154///LOC100288778///WASH1///WASH7P///WASH2P///WASH3P","microRNA 6859-1///microRNA 6859-2///WAS protein family homolog 6-like///WAS protein family homolog 1 pseudogene///WAS protein family homolog 1///WAS protein family homolog 7 pseudogene///WAS protein family homolog 2 pseudogene///WAS protein family homolog 3 pseudogene",TRUE
+"233929_x_at",0.877601576789759,0.528150018887796,0.640918074704714,-5.74156603339366,0.192570476412639,"MIR6859-1///MIR6859-2///LOC101930154///LOC100288778///WASH1///WASH7P///WASH2P///WASH3P","microRNA 6859-1///microRNA 6859-2///WAS protein family homolog 6-like///WAS protein family homolog 1 pseudogene///WAS protein family homolog 1///WAS protein family homolog 7 pseudogene///WAS protein family homolog 2 pseudogene///WAS protein family homolog 3 pseudogene",TRUE
+"207842_s_at",0.988713664405312,0.945394295939064,-0.0692722654147465,-5.93734650708976,-0.0315261854856921,"MIR6866///CASC3","microRNA 6866///cancer susceptibility candidate 3",TRUE
+"203071_at",0.823885611874558,0.391140353496624,0.874662386109042,-5.57377865882048,1.17698979883019,"MIR6872///SEMA3B","microRNA 6872///semaphorin 3B",TRUE
+"214262_at",0.937985925753626,0.725666701960249,-0.355378769805914,-5.8783568076592,-0.372592871783989,"MIR6875///TRIP6","microRNA 6875///thyroid hormone receptor interactor 6",TRUE
+"221189_s_at",0.711902920992134,0.185456767278429,-1.36660880090609,-5.06880330099605,-0.511944076857102,"MIR6878///TARS2","microRNA 6878///threonyl-tRNA synthetase 2, mitochondrial (putative)",TRUE
+"202861_at",0.769847953580141,0.278109859233003,1.11187842215897,-5.35483687582919,0.895042639514731,"MIR6883///PER1","microRNA 6883///period circadian clock 1",TRUE
+"242832_at",0.782096995485383,0.303832081618447,1.0526823515502,-5.41389799825839,0.28843981672793,"MIR6883///PER1","microRNA 6883///period circadian clock 1",TRUE
+"36829_at",0.936992192746977,0.717848901677805,0.365983078056228,-5.87465422690408,0.0892543301191786,"MIR6883///PER1","microRNA 6883///period circadian clock 1",TRUE
+"244677_at",0.948429371744093,0.76486725776695,0.302799460133036,-5.89512427780558,0.144386155549557,"MIR6883///PER1","microRNA 6883///period circadian clock 1",TRUE
+"213043_s_at",0.831893282610777,0.407825150696203,-0.843752781755233,-5.59875828093527,-0.490758352911953,"MIR6884///MED24","microRNA 6884///mediator complex subunit 24",TRUE
+"217846_at",0.981944022360435,0.913523318253279,0.109842230525983,-5.93380861845899,0.0379298450306198,"MIR6890///QARS","microRNA 6890///glutaminyl-tRNA synthetase",TRUE
+"223913_s_at",0.676468346171966,0.143349895604388,-1.51722291667096,-4.87666591702544,-1.57608516707491,"MIR7-3HG","MIR7-3 host gene",TRUE
+"223973_at",0.708894565317004,0.181080055137678,1.38090212991854,-5.05127856201005,1.02435731557196,"MIR7-3HG","MIR7-3 host gene",TRUE
+"202392_s_at",0.819018525257656,0.373529584884221,-0.908230789973525,-5.54570653474832,-0.465249553089928,"MIR7109///PISD","microRNA 7109///phosphatidylserine decarboxylase",TRUE
+"203857_s_at",0.96200396340887,0.827474444539288,0.220534394970876,-5.91602268553254,0.0909135275807582,"MIR7110///PDIA5","microRNA 7110///protein disulfide isomerase family A member 5",TRUE
+"229562_at",0.589867324183875,0.0680653488482134,1.91818272167418,-4.29075778620219,0.907998233785117,"MIR7111///RPL10A","microRNA 7111///ribosomal protein L10a",TRUE
+"212563_at",0.670152406964446,0.135916716623242,1.54746516529868,-4.83614113745574,0.773386816908349,"MIR7112///BOP1","microRNA 7112///block of proliferation 1",TRUE
+"216397_s_at",0.748440891167983,0.241359801983526,1.20382877144254,-5.2574526128707,0.401714093306685,"MIR7112///BOP1","microRNA 7112///block of proliferation 1",TRUE
+"232169_x_at",0.876664891408244,0.525601068998084,-0.644919948206574,-5.73910873780774,-0.200036922058796,"MIR7113///MIR4691///NDUFS8","microRNA 7113///microRNA 4691///NADH:ubiquinone oxidoreductase core subunit S8",TRUE
+"203189_s_at",0.943988850936011,0.749377954661302,0.32346281905067,-5.88885103625043,0.145120666001548,"MIR7113///MIR4691///NDUFS8","microRNA 7113///microRNA 4691///NADH:ubiquinone oxidoreductase core subunit S8",TRUE
+"203190_at",0.953553103224247,0.78566519762098,0.275262558010454,-5.90284619681612,0.0996115422195363,"MIR7113///MIR4691///NDUFS8","microRNA 7113///microRNA 4691///NADH:ubiquinone oxidoreductase core subunit S8",TRUE
+"221214_s_at",0.603702127972549,0.0777361132039959,-1.84973260846567,-4.39786362475179,-0.834170857853199,"MIR7114///NSMF","microRNA 7114///NMDA receptor synaptonuclear signaling and neuronal migration factor",TRUE
+"231444_at",0.470885186348082,0.0254543037942378,2.39587028133515,-3.47433790958492,1.71964000414735,"MIR7515HG///MIR7515","MIR7515 host gene///microRNA 7515",TRUE
+"201762_s_at",0.845588139978284,0.443114577431544,-0.780918536908636,-5.64694245275646,-0.23090272181719,"MIR7703///PSME2","microRNA 7703///proteasome activator subunit 2",TRUE
+"211430_s_at",0.971867994936839,0.865319115191513,0.171587764723717,-5.92535335830796,0.119120533340071,"MIR8071-2///MIR8071-1///IGHV4-31///IGHM///IGHG2///IGHG1","microRNA 8071-2///microRNA 8071-1///immunoglobulin heavy variable 4-31///immunoglobulin heavy constant mu///immunoglobulin heavy constant gamma 2 (G2m marker)///immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"238242_at",0.998870448604467,0.995778274710652,0.00535119339369865,-5.93966953357412,0.00395228284449578,"MIR8072///LOC100293704","microRNA 8072///serine/arginine repetitive matrix protein 3-like",TRUE
+"204908_s_at",0.720021194788968,0.196036803586449,-1.33312515392042,-5.10926008939625,-0.892118660056811,"MIR8085///BCL3","microRNA 8085///B-cell CLL/lymphoma 3",TRUE
+"204907_s_at",0.872010957446544,0.514812385362268,-0.661977371908103,-5.72847023349919,-0.414472548126028,"MIR8085///BCL3","microRNA 8085///B-cell CLL/lymphoma 3",TRUE
+"238603_at",0.56065672695196,0.0543685773442943,-2.03149760808391,-4.10760589026288,-1.85622462594697,"MIR9-3HG","MIR9-3 host gene",TRUE
+"235936_at",0.648363830232085,0.119510026174284,-1.61939385294,-4.73723765255632,-1.87353412806221,"MIR9-3HG","MIR9-3 host gene",TRUE
+"240365_at",0.899808883319249,0.592949339728616,0.542411590319551,-5.79739156945512,0.582192618121558,"MIR924HG","MIR924 host gene",TRUE
+"34225_at",0.565993041605217,0.0568818645394991,-2.00893852786832,-4.14463189804096,-0.784385289570611,"MIR943///NELFA","microRNA 943///negative elongation factor complex member A",TRUE
+"203112_s_at",0.632949074657601,0.104218612913369,-1.69430901296874,-4.63055855399637,-0.632637395246119,"MIR943///NELFA","microRNA 943///negative elongation factor complex member A",TRUE
+"239999_at",0.85334340854827,0.461109954299265,0.750059465997418,-5.66932019945011,0.806767819857683,"MIR99AHG","mir-99a-let-7c cluster host gene",TRUE
+"1559901_s_at",0.943824539742785,0.748595551250953,0.324510321627849,-5.88852210510684,0.259575738607627,"MIR99AHG","mir-99a-let-7c cluster host gene",TRUE
+"1559412_at",0.957430653957785,0.807548623560962,0.24652091420272,-5.91012667945755,0.129223869759948,"MIR99AHG","mir-99a-let-7c cluster host gene",TRUE
+"232480_at",0.899808883319249,0.592642039939197,0.542865434594765,-5.79715502805062,0.307705026657724,"MIRLET7BHG","MIRLET7B host gene",TRUE
+"1557342_a_at",0.972659629123427,0.867807451003786,-0.168385765790519,-5.92588283519005,-0.0824120412772364,"MIRLET7BHG","MIRLET7B host gene",TRUE
+"227793_at",0.856857560656867,0.471220759768735,0.733037095693025,-5.68129848774461,0.432636745394025,"MIRLET7D","microRNA let-7d",TRUE
+"1559129_a_at",0.346761268605178,0.00891082912465066,2.86734286228751,-2.573941907305,2.22048723969217,"MIRLET7DHG","MIRLET7D host gene",TRUE
+"221559_s_at",0.819018525257656,0.37503426655864,0.905322549064574,-5.54817727697269,0.305521051788137,"MIS12","MIS12, kinetochore complex component",TRUE
+"228597_at",0.818854105808043,0.372741989729985,-0.909756140003333,-5.54440772478537,-0.319089504190847,"MIS18A","MIS18 kinetochore protein A",TRUE
+"229671_s_at",0.820288124919738,0.378473356610675,-0.898704291544526,-5.55377263034722,-0.331862389751509,"MIS18A","MIS18 kinetochore protein A",TRUE
+"219004_s_at",0.933133133122159,0.704521915597306,-0.384160046495799,-5.86805773365604,-0.135921972870229,"MIS18A","MIS18 kinetochore protein A",TRUE
+"244173_at",0.769847953580141,0.27826768357197,1.1115033935284,-5.35522009619975,0.879110218039298,"MIS18BP1","MIS18 binding protein 1",TRUE
+"226630_at",0.816358096928248,0.367532048269848,0.91990056046984,-5.53571879016494,0.323670655172213,"MIS18BP1","MIS18 binding protein 1",TRUE
+"206500_s_at",0.939718147611924,0.729585654284015,0.350078643276258,-5.88016708292736,0.117973139733947,"MIS18BP1","MIS18 binding protein 1",TRUE
+"212925_at",0.682504456039784,0.14999696454084,1.49124936021138,-4.91096060726818,1.1643872704054,"MISP","mitotic spindle positioning",TRUE
+"226329_s_at",0.910396871421039,0.627428706209715,0.492186835831059,-5.82237730155447,0.178433674886168,"MITD1","microtubule interacting and trafficking domain containing 1",TRUE
+"1554874_at",0.680271564802837,0.147469065817262,1.50101418702283,-4.898123088566,1.21720247753655,"MITF","melanogenesis associated transcription factor",TRUE
+"207233_s_at",0.736020435324742,0.22115469191973,1.25894069752057,-5.19586715540449,0.716898981286418,"MITF","melanogenesis associated transcription factor",TRUE
+"226066_at",0.774360462422895,0.290609638681894,1.08264152256456,-5.38436742401538,0.852388779423251,"MITF","melanogenesis associated transcription factor",TRUE
+"231746_at",0.822173415758858,0.386094556561431,-0.884177445108493,-5.56592099361773,-0.605632932920462,"MIXL1","Mix paired-like homeobox",TRUE
+"212020_s_at",0.360736459722853,0.0103306622028206,2.80260770084359,-2.70197117872985,0.857545250247352,"MKI67","marker of proliferation Ki-67",TRUE
+"212021_s_at",0.54344488073991,0.0463249672720932,2.11055244356788,-3.97572531390346,0.867018210784165,"MKI67","marker of proliferation Ki-67",TRUE
+"212022_s_at",0.557502997422893,0.0522312469701772,2.05142565557674,-4.07467114458396,0.914128152101199,"MKI67","marker of proliferation Ki-67",TRUE
+"212023_s_at",0.567908857498119,0.0578325637269762,2.00063570637522,-4.15818983852347,0.892061121227814,"MKI67","marker of proliferation Ki-67",TRUE
+"218138_at",0.618124814816155,0.0890459786586183,-1.77851322455356,-4.50634530039595,-0.790387084716306,"MKKS","McKusick-Kaufman syndrome",TRUE
+"222530_s_at",0.98539961718117,0.928223331363486,0.0911106931835752,-5.93564110119961,0.0410104897503807,"MKKS","McKusick-Kaufman syndrome",TRUE
+"1559902_at",0.457032025390949,0.0226162985766968,2.45055939327524,-3.37409536944928,1.78166235129815,"MKL1","megakaryoblastic leukemia (translocation) 1",TRUE
+"212748_at",0.565795244949651,0.056670856251428,2.01079805393164,-4.14159027976212,0.702278068584818,"MKL1","megakaryoblastic leukemia (translocation) 1",TRUE
+"215291_at",0.721907781985393,0.19813662234923,1.32664918989858,-5.11698748788916,0.77224237207539,"MKL1","megakaryoblastic leukemia (translocation) 1",TRUE
+"1555763_x_at",0.829030239823335,0.400152938553014,0.857863037928219,-5.58745886394197,0.455099925592552,"MKL1","megakaryoblastic leukemia (translocation) 1",TRUE
+"215292_s_at",0.929125618312698,0.688060739474842,0.406795952019969,-5.85940268104393,0.203125887517848,"MKL1","megakaryoblastic leukemia (translocation) 1",TRUE
+"1570202_a_at",0.6708432030569,0.136469787654573,-1.54516868935968,-4.83924066773212,-1.08483804752027,"MKL2","MKL1/myocardin like 2",TRUE
+"218259_at",0.848701670618582,0.449163814193311,-0.770461903042111,-5.65462062600371,-0.313474937711479,"MKL2","MKL1/myocardin like 2",TRUE
+"1562497_at",0.90496994347229,0.610605296963903,0.516524635741555,-5.81056500560008,0.204323473398537,"MKL2","MKL1/myocardin like 2",TRUE
+"1558777_at",0.974451535839172,0.875084432882851,0.159031923090397,-5.92737259520168,0.0959368209057008,"MKL2","MKL1/myocardin like 2",TRUE
+"1558778_s_at",0.978257169730337,0.895183435025448,0.133269274447507,-5.93103659952396,0.103879704620522,"MKL2","MKL1/myocardin like 2",TRUE
+"244171_at",0.857436624285661,0.472963496705234,0.730124961046532,-5.68332155823931,0.541726352550613,"MKLN1","muskelin 1",TRUE
+"235067_at",0.964263441785771,0.83570504254018,-0.209846547913836,-5.91825810768383,-0.0737504225069472,"MKLN1","muskelin 1",TRUE
+"1560145_at",0.975265330414469,0.880369046212155,0.152248215622173,-5.92839989388395,0.095197010591618,"MKLN1","muskelin 1",TRUE
+"242984_at",0.980267546812478,0.908083181763723,0.116784194289187,-5.93304282933378,0.0421352353562732,"MKLN1","muskelin 1",TRUE
+"204423_at",0.986807569142828,0.938310963047048,0.0782762082493834,-5.93669960527926,0.0252642464206048,"MKLN1","muskelin 1",TRUE
+"225526_at",0.997171203405,0.985688670222023,0.018141090725248,-5.93952318994706,0.00570199357684231,"MKLN1","muskelin 1",TRUE
+"243256_at",0.618124814816155,0.089086850310952,1.77827038335003,-4.50670990826953,0.71667124383321,"MKNK1","MAP kinase interacting serine/threonine kinase 1",TRUE
+"209467_s_at",0.635368778245437,0.10636475208532,1.68325628339428,-4.64652804618015,0.516034821156534,"MKNK1","MAP kinase interacting serine/threonine kinase 1",TRUE
+"1560720_at",0.764181892792555,0.264217549178792,1.14551727417638,-5.3199986193981,0.897083511432423,"MKNK1","MAP kinase interacting serine/threonine kinase 1",TRUE
+"240810_at",0.699223603113681,0.170678339408417,-1.41600729293029,-5.00759701040506,-0.874260471496358,"MKNK1-AS1","MKNK1 antisense RNA 1",TRUE
+"223199_at",0.791045390251277,0.321086967084312,-1.01494655656183,-5.4500326906591,-0.536570569416464,"MKNK2","MAP kinase interacting serine/threonine kinase 2",TRUE
+"218205_s_at",0.841550580403629,0.433210251777281,-0.798229313123077,-5.63401709094329,-0.352922423237521,"MKNK2","MAP kinase interacting serine/threonine kinase 2",TRUE
+"201285_at",0.682825347106105,0.150805161797791,-1.48815574891378,-4.915013635565,-0.496605108126461,"MKRN1","makorin ring finger protein 1",TRUE
+"209845_at",0.857287594027564,0.472308516470166,-0.731218698643514,-5.68256263144842,-0.276825465880661,"MKRN1","makorin ring finger protein 1",TRUE
+"222510_s_at",0.971084206066165,0.861390272213948,0.176647167974197,-5.92449647329206,0.0600566845725972,"MKRN2","makorin ring finger protein 2",TRUE
+"216995_x_at",0.989586772349659,0.949176063615364,-0.0644675407698558,-5.93765941802106,-0.0328282098510617,"MKRN2","makorin ring finger protein 2",TRUE
+"218071_s_at",0.99783553534859,0.989800581987753,-0.0129284525542577,-5.93960207096587,-0.00403579735443138,"MKRN2","makorin ring finger protein 2",TRUE
+"206585_at",0.475296051772729,0.0262294478629819,2.38191525061449,-3.49971711052761,1.55347615934533,"MKRN3","makorin ring finger protein 3",TRUE
+"217115_at",0.887189117711068,0.551639346057713,0.604519258429626,-5.76323990848505,0.298221195761445,"MKRN7P","makorin ring finger protein 7, pseudogene",TRUE
+"218630_at",0.940778455596726,0.734977606022845,-0.342803016617048,-5.88260831166189,-0.147509336195133,"MKS1","Meckel syndrome, type 1",TRUE
+"1555820_a_at",0.998347572104896,0.99229702390575,0.00976392135052765,-5.9396370471013,0.00346428190945858,"MKS1","Meckel syndrome, type 1",TRUE
+"236014_at",0.571677937624457,0.0596722734777954,1.98490717762246,-4.18377013496155,1.17653290740147,"MKX","mohawk homeobox",TRUE
+"241902_at",0.98539961718117,0.928703300580371,0.0904996908484506,-5.93569512638045,0.139801628340163,"MKX","mohawk homeobox",TRUE
+"239468_at",0.990810941805126,0.956199681130259,0.0555480919035679,-5.9381807151192,0.0880542297171942,"MKX","mohawk homeobox",TRUE
+"206426_at",0.850693751204364,0.453551588679643,0.762930613358377,-5.66009020480474,0.607541667984006,"MLANA","melan-A",TRUE
+"206427_s_at",0.992129073515375,0.963446982257738,0.0463494124895124,-5.93863719276115,0.032194234873514,"MLANA","melan-A",TRUE
+"213395_at",0.740610299769501,0.230577923797658,1.23278170814156,-5.2253952275918,0.946832300403151,"MLC1","megalencephalic leukoencephalopathy with subcortical cysts 1",TRUE
+"200617_at",0.774230543658252,0.287773771809128,-1.08919370806522,-5.37781033722418,-0.411705474991097,"MLEC","malectin",TRUE
+"200616_s_at",0.925091998149497,0.675976783352679,0.423550751969789,-5.85268239857723,0.168158851536477,"MLEC","malectin",TRUE
+"204782_at",0.565043084457947,0.0563503558398213,2.01363429723135,-4.13694743680663,1.83208004278834,"MLF1","myeloid leukemia factor 1",TRUE
+"204784_s_at",0.757015081911646,0.25270142404242,1.17440450328773,-5.28935295142678,1.37502071385906,"MLF1","myeloid leukemia factor 1",TRUE
+"204783_at",0.797960028258877,0.331978286027479,0.991852924705469,-5.47155758661156,1.04900773451577,"MLF1","myeloid leukemia factor 1",TRUE
+"200948_at",0.976371465776674,0.886313107354386,-0.144626708548787,-5.92950076966793,-0.0530378076065379,"MLF2","myeloid leukemia factor 2",TRUE
+"202520_s_at",0.896656808192074,0.581469845290502,0.559444973392581,-5.78838214972595,0.678475661346045,"MLH1","mutL homolog 1",TRUE
+"204838_s_at",0.6708432030569,0.136718453591835,-1.54413867286448,-4.84062968790814,-0.523763430501816,"MLH3","mutL homolog 3",TRUE
+"217216_x_at",0.819780516863333,0.37765071695716,-0.900283778388855,-5.55244071320815,-0.270643441515091,"MLH3","mutL homolog 3",TRUE
+"214525_x_at",0.962351204352784,0.828524470649699,-0.219169446733944,-5.91631432812461,-0.0618695555741962,"MLH3","mutL homolog 3",TRUE
+"235377_at",0.931758470868451,0.698746425652459,0.3920781144183,-5.86508568463432,0.333119499781112,"MLIP","muscular LMNA-interacting protein",TRUE
+"216401_x_at",0.963120895816356,0.832435469019792,0.214089190643636,-5.91738396557958,0.0798419494072462,"MLIP","muscular LMNA-interacting protein",TRUE
+"1558653_at",0.895690630367785,0.575478779063504,-0.568401137279243,-5.78353658412524,-0.416176385370961,"MLK7-AS1","MLK7 antisense RNA 1",TRUE
+"238025_at",0.42510292927997,0.018009729670021,2.5546477365597,-3.18000578787395,1.31225854174871,"MLKL","mixed lineage kinase domain like",TRUE
+"224993_at",0.615821255316333,0.0865024524330209,-1.79381804540338,-4.48329302962117,-0.558838272650489,"MLLT1","MLLT1, super elongation complex subunit",TRUE
+"214477_at",0.955925931146022,0.800960368188318,0.255150485551945,-5.90802445956634,0.115879074305418,"MLLT1","MLLT1, super elongation complex subunit",TRUE
+"230122_at",0.722288531465626,0.198713563608705,-1.32487927214736,-5.11909391741389,-0.475075835917497,"MLLT10","myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10",TRUE
+"216503_s_at",0.729229845942426,0.211362516303293,-1.28704492522704,-5.16355238916129,-0.668376468525179,"MLLT10","myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10",TRUE
+"216506_x_at",0.822173415758858,0.386622519878754,-0.883178063897366,-5.56675000242256,-0.29662305775062,"MLLT10","myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10",TRUE
+"1563321_s_at",0.831875452294783,0.407480389024602,-0.844383189329596,-5.59825718429244,-0.274443428988455,"MLLT10","myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10",TRUE
+"216480_x_at",0.851319596585235,0.454705913719145,0.760956616791308,-5.66151541551227,0.398671174665234,"MLLT10","myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10",TRUE
+"205408_at",0.917102138198416,0.649516195032299,0.460682418333375,-5.83684022863619,0.140709035467728,"MLLT10","myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10",TRUE
+"216509_x_at",0.929088231432081,0.687485581023235,-0.407590710759413,-5.85908993443356,-0.123760137746157,"MLLT10","myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10",TRUE
+"225992_at",0.952293443370532,0.781481549394563,-0.280783663049729,-5.90135647003799,-0.113582766374625,"MLLT10","myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10",TRUE
+"211071_s_at",0.371752195733366,0.011223752401328,2.76609643277333,-2.77362821904269,2.11254987918652,"MLLT11","myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11",TRUE
+"204917_s_at",0.695744345349551,0.165485813677472,-1.43417585770422,-4.98463584749216,-0.966624891062257,"MLLT3","MLLT3, super elongation complex subunit",TRUE
+"204918_s_at",0.734730148360473,0.219595493021018,-1.26335081947577,-5.19083665476296,-0.801128597685021,"MLLT3","MLLT3, super elongation complex subunit",TRUE
+"1569652_at",0.869850840015332,0.50766925785079,0.673380288366916,-5.72120994895671,0.468945530989117,"MLLT3","MLLT3, super elongation complex subunit",TRUE
+"1555155_at",0.774230543658252,0.289202501159188,1.0858868894798,-5.38112403911933,0.335609007768658,"MLLT6","MLLT6, PHD finger domain containing",TRUE
+"225628_s_at",0.967315591387789,0.847102468074011,0.195087313362464,-5.92116329880346,0.112045207991457,"MLLT6","MLLT6, PHD finger domain containing",TRUE
+"224784_at",0.978197434639598,0.89430174147392,-0.134397353403158,-5.93088965811993,-0.0734181279099619,"MLLT6","MLLT6, PHD finger domain containing",TRUE
+"207473_at",0.974871801904735,0.876743703419077,-0.156901157219705,-5.92770008215418,-0.0567846200033877,"MLN","motilin",TRUE
+"221365_at",0.998347572104896,0.992735862392582,-0.00920765390299809,-5.93964218718758,-0.00622476573461661,"MLNR","motilin receptor",TRUE
+"218211_s_at",0.722869421140201,0.199277111026204,-1.32315431523586,-5.12114455789182,-1.29588291298353,"MLPH","melanophilin",TRUE
+"220587_s_at",0.56861088242915,0.0584391156909524,-1.99540156767538,-4.16671750192993,-0.710498815358566,"MLST8","MTOR associated protein, LST8 homolog",TRUE
+"213708_s_at",0.778006206647445,0.297203362833371,-1.06758252394741,-5.39930370946054,-0.314474074760811,"MLX","MLX, MAX dimerization protein",TRUE
+"217909_s_at",0.896345073598643,0.580529957040723,-0.560846957796627,-5.787628559799,-0.181596244208313,"MLX","MLX, MAX dimerization protein",TRUE
+"217910_x_at",0.91704891241952,0.648935263963332,-0.461504857616739,-5.83647456838356,-0.137603627334247,"MLX","MLX, MAX dimerization protein",TRUE
+"210752_s_at",0.956398858120188,0.80239026061488,0.25327589278191,-5.90848723398666,0.0632777455115612,"MLX","MLX, MAX dimerization protein",TRUE
+"1570347_at",0.975398143273847,0.882098119432769,0.150030256707084,-5.92872608190842,0.0801105440255734,"MLX","MLX, MAX dimerization protein",TRUE
+"231401_s_at",0.993615552413264,0.969821736384002,0.0382616321293289,-5.93897046862001,0.0152658514182553,"MLX","MLX, MAX dimerization protein",TRUE
+"202519_at",0.703581041988101,0.175207631970429,1.40051729091779,-5.02698291224024,0.723542237205409,"MLXIP","MLX interacting protein",TRUE
+"211789_s_at",0.712975827977365,0.187430426279125,1.36025042913168,-5.07655035034098,1.53135833291963,"MLXIP","MLX interacting protein",TRUE
+"1554886_a_at",0.787021937725689,0.312879905594981,-1.03271225092378,-5.43316891285183,-0.625353791141116,"MLXIP","MLX interacting protein",TRUE
+"225157_at",0.923573053923573,0.67196590919213,0.429139081423596,-5.85038165688337,0.193064797306906,"MLXIP","MLX interacting protein",TRUE
+"221163_s_at",0.870517518639056,0.509341199480464,0.670703292418297,-5.72292506943298,0.533250785515742,"MLXIPL","MLX interacting protein like",TRUE
+"218869_at",0.717937808890208,0.193850445862732,-1.33992599408629,-5.10111099630915,-0.625882588457673,"MLYCD","malonyl-CoA decarboxylase",TRUE
+"230530_at",0.85334340854827,0.461158237277041,-0.74997765281704,-5.6693783928385,-0.420123449884004,"MLYCD","malonyl-CoA decarboxylase",TRUE
+"237831_x_at",0.628076638668209,0.0994698786324284,1.71946957086751,-4.59391278385732,1.64399415355531,"MMAA","methylmalonic aciduria (cobalamin deficiency) cblA type",TRUE
+"242750_at",0.702324656770028,0.173747477045659,-1.40547566693454,-5.02079656987387,-0.607881402854189,"MMAA","methylmalonic aciduria (cobalamin deficiency) cblA type",TRUE
+"236347_at",0.906507435035949,0.614568181425697,-0.510763708773964,-5.81341128707356,-0.178012350125764,"MMAA","methylmalonic aciduria (cobalamin deficiency) cblA type",TRUE
+"239852_at",0.99667999022307,0.983463840375576,0.0209616953556675,-5.93946947104481,0.0131674947891014,"MMAA","methylmalonic aciduria (cobalamin deficiency) cblA type",TRUE
+"242702_at",0.998347572104896,0.992988746192599,0.00888710219288483,-5.93964501229115,0.0039341351235489,"MMAA","methylmalonic aciduria (cobalamin deficiency) cblA type",TRUE
+"238975_at",0.813660971341375,0.36457368954588,-0.925703505452332,-5.53070852311193,-0.896412400007404,"MMAB","methylmalonic aciduria (cobalamin deficiency) cblB type",TRUE
+"225826_at",0.902521078772712,0.601647705150577,-0.529612379776324,-5.80398322256857,-0.195030446161189,"MMAB","methylmalonic aciduria (cobalamin deficiency) cblB type",TRUE
+"242082_at",0.920800738105699,0.663262324090163,-0.441313972267931,-5.84526665641607,-0.380972273504191,"MMAB","methylmalonic aciduria (cobalamin deficiency) cblB type",TRUE
+"211774_s_at",0.94943075115007,0.771527075196269,-0.29395672307842,-5.89768350228819,-0.0764692516959773,"MMACHC","methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria",TRUE
+"217883_at",0.919485127002411,0.658101446690345,-0.448565214353496,-5.84215349458732,-0.101529274211535,"MMADHC","methylmalonic aciduria and homocystinuria, cblD type",TRUE
+"244523_at",0.637485146909712,0.108747988859762,1.671201686781,-4.66385491016084,0.730222533904048,"MMD","monocyte to macrophage differentiation associated",TRUE
+"203414_at",0.764430688544079,0.264499770119418,1.14482113700366,-5.32072885651613,0.728939807224547,"MMD","monocyte to macrophage differentiation associated",TRUE
+"1569998_at",0.821533954989003,0.383839626484473,-0.888455874811243,-5.56236211940668,-0.56370564515318,"MMD2","monocyte to macrophage differentiation associated 2",TRUE
+"230826_at",0.895213601869362,0.573328671691281,0.57162682461694,-5.78177311404692,0.140271489580248,"MMD2","monocyte to macrophage differentiation associated 2",TRUE
+"203434_s_at",0.800477843494704,0.336295858529005,0.982843219871313,-5.47983319209542,1.12222631195199,"MME","membrane metallo-endopeptidase",TRUE
+"203435_s_at",0.853946163207709,0.46280992607537,0.747182019002183,-5.67136330280836,0.269599614471611,"MME","membrane metallo-endopeptidase",TRUE
+"1552930_at",0.658906344891819,0.127027537501413,-1.58547892000804,-4.78430871510784,-0.860112714532383,"MMEL1","membrane metallo-endopeptidase-like 1",TRUE
+"225125_at",0.936361288293618,0.716104451919696,-0.36835510651828,-5.87381130510401,-0.100628747410944,"MMGT1","membrane magnesium transporter 1",TRUE
+"204475_at",0.806307740057893,0.34715639418682,0.960525642791961,-5.50003575559721,1.36046248763373,"MMP1","matrix metallopeptidase 1",TRUE
+"205680_at",0.620912785033482,0.0909036873129414,1.76757116668864,-4.52273778913121,1.24264002236821,"MMP10","matrix metallopeptidase 10",TRUE
+"203876_s_at",0.731548533938014,0.215226060564734,1.27583896867754,-5.17651019922102,1.23748027909923,"MMP11","matrix metallopeptidase 11",TRUE
+"203878_s_at",0.822173415758858,0.386105806622457,0.884156140584757,-5.5659386752583,0.551927715803206,"MMP11","matrix metallopeptidase 11",TRUE
+"235908_at",0.842917136850585,0.436755200123769,0.792005754008239,-5.63869471889919,0.389340598140898,"MMP11","matrix metallopeptidase 11",TRUE
+"203877_at",0.97928472590149,0.899795740466655,-0.127370930872482,-5.93178477104372,-0.0642651330404442,"MMP11","matrix metallopeptidase 11",TRUE
+"204580_at",0.573496623084053,0.0602846542802902,1.97976696059309,-4.19210050487343,0.802023521407616,"MMP12","matrix metallopeptidase 12",TRUE
+"205959_at",0.682825347106105,0.151004448689671,1.48739499627501,-4.91600928175029,1.02578706386672,"MMP13","matrix metallopeptidase 13",TRUE
+"202828_s_at",0.0820586380687064,0.00028746459720212,4.29799255766842,0.442951580452046,4.74473549197771,"MMP14","matrix metallopeptidase 14",TRUE
+"202827_s_at",0.228900728752571,0.00288645670948063,3.3485703859707,-1.58967944911525,4.05639315338865,"MMP14","matrix metallopeptidase 14",TRUE
+"217279_x_at",0.291178024882244,0.00509889141728715,3.10805061528404,-2.08802597128513,3.03633454808172,"MMP14","matrix metallopeptidase 14",TRUE
+"160020_at",0.353280147900821,0.00939495811701498,2.84423084746398,-2.6197918213859,1.21803993338413,"MMP14","matrix metallopeptidase 14",TRUE
+"203365_s_at",0.859781203630624,0.478049356934083,0.7216622924888,-5.68915717585867,0.705853900852906,"MMP15","matrix metallopeptidase 15",TRUE
+"243883_at",0.879960488971225,0.535115567626982,-0.630035333268272,-5.74817404765087,-0.451012449538594,"MMP15","matrix metallopeptidase 15",TRUE
+"208167_s_at",0.627092759817312,0.0985277593759478,-1.7245824708462,-4.58641658765816,-1.14100703530727,"MMP16","matrix metallopeptidase 16",TRUE
+"207013_s_at",0.708978267842592,0.181565865685084,-1.37930216790489,-5.05324777092873,-0.634784772046054,"MMP16","matrix metallopeptidase 16",TRUE
+"207012_at",0.715677574404058,0.19146137826358,-1.3474265426221,-5.09208314927808,-0.872039813256153,"MMP16","matrix metallopeptidase 16",TRUE
+"223614_at",0.880685398344064,0.536193307469754,-0.628358363344072,-5.74918262426216,-0.788974403918131,"MMP16","matrix metallopeptidase 16",TRUE
+"208166_at",0.996544286433033,0.982775120602698,-0.0218348777925681,-5.93945127027932,-0.0149142911437323,"MMP16","matrix metallopeptidase 16",TRUE
+"206234_s_at",0.65284137151906,0.121681567933597,-1.60941826281025,-4.7511631654632,-1.11304845090744,"MMP17","matrix metallopeptidase 17",TRUE
+"204575_s_at",0.850206060456713,0.452829759223548,0.764166544554834,-5.65919609509365,0.905814418926501,"MMP19","matrix metallopeptidase 19",TRUE
+"204574_s_at",0.965606225759743,0.839203506126973,0.205311251349833,-5.9191732800524,0.145424975466945,"MMP19","matrix metallopeptidase 19",TRUE
+"201069_at",0.0515681170022718,7.30226221764165e-05,4.85787537934224,1.64775046949999,3.03833364008698,"MMP2","matrix metallopeptidase 2",TRUE
+"1566678_at",0.843095426822889,0.437187474148282,0.791248980855642,-5.6392611605016,0.464366359980213,"MMP2","matrix metallopeptidase 2",TRUE
+"1566677_at",0.84932977991296,0.450331177802627,0.768453880083405,-5.65608390905931,0.489331421224896,"MMP2","matrix metallopeptidase 2",TRUE
+"207599_at",0.894616046525079,0.571355832749689,-0.574591963948753,-5.78014355574652,-0.45833016550207,"MMP20","matrix metallopeptidase 20",TRUE
+"1552592_at",0.642592458809121,0.112527304681831,1.65253559758115,-4.69049801589534,1.58897063636465,"MMP21","matrix metallopeptidase 21",TRUE
+"207118_s_at",0.858363423465728,0.474105478285167,0.728220118861842,-5.68464072128335,0.258204679373327,"MMP23A///MMP23B","matrix metallopeptidase 23A (pseudogene)///matrix metallopeptidase 23B",TRUE
+"213171_s_at",0.916023212016902,0.645630919035817,0.466189078370136,-5.83437976186238,0.279715219232973,"MMP24","matrix metallopeptidase 24",TRUE
+"208387_s_at",0.954577684533304,0.79248456387136,-0.266281743993138,-5.90520668692733,-0.197083789330444,"MMP24","matrix metallopeptidase 24",TRUE
+"221953_s_at",0.686108994812404,0.154789430444545,-1.47309909365288,-4.93464289401173,-1.09276175619962,"MMP24-AS1","MMP24 antisense RNA 1",TRUE
+"225860_at",0.8288884913487,0.399697594898168,-0.85870590731761,-5.58677837249546,-0.59369135962408,"MMP24-AS1","MMP24 antisense RNA 1",TRUE
+"78047_s_at",0.84899624366548,0.449611167939385,-0.769692020901179,-5.6551820794387,-0.457723995599688,"MMP24-AS1","MMP24 antisense RNA 1",TRUE
+"49679_s_at",0.860714927752408,0.480584900655939,-0.717462918144108,-5.69202893071056,-0.405310352552103,"MMP24-AS1","MMP24 antisense RNA 1",TRUE
+"207289_at",0.825648186672984,0.393057831489767,0.871067439802846,-5.57672686885749,0.227567762867208,"MMP25","matrix metallopeptidase 25",TRUE
+"207890_s_at",0.835952408568777,0.416607322466027,0.82780709474237,-5.61131683266878,0.411843229399538,"MMP25","matrix metallopeptidase 25",TRUE
+"239180_at",0.879111461403304,0.532747070298238,0.633727140972816,-5.74594457642717,0.341047031353617,"MMP25-AS1","MMP25 antisense RNA 1",TRUE
+"228085_at",0.91876780831279,0.655066577912722,0.452840737460688,-5.84029457348523,0.259459132497216,"MMP25-AS1","MMP25 antisense RNA 1",TRUE
+"220541_at",0.915639438262336,0.644348281311467,0.468010188787616,-5.83355975981989,0.191160648908464,"MMP26","matrix metallopeptidase 26",TRUE
+"220783_at",0.943512938262733,0.747566550372296,0.325888539796472,-5.88808772070572,0.10623673788866,"MMP27","matrix metallopeptidase 27",TRUE
+"219909_at",0.0587296990640411,0.000118157602140732,4.66085726322953,1.22544974416428,3.37046986037169,"MMP28","matrix metallopeptidase 28",TRUE
+"239273_s_at",0.123921805043951,0.000725207453920146,3.91996187701772,-0.373184027539844,3.52927530186058,"MMP28","matrix metallopeptidase 28",TRUE
+"239272_at",0.135265250185742,0.000868369507365259,3.84609207140782,-0.532102838162339,3.10306103315705,"MMP28","matrix metallopeptidase 28",TRUE
+"222937_s_at",0.655235030401569,0.123970794919295,1.59906182572042,-4.76554972614267,0.969070469605386,"MMP28","matrix metallopeptidase 28",TRUE
+"224207_x_at",0.708894565317004,0.181476144350514,1.37959739911552,-5.05288454742666,0.871062763467944,"MMP28","matrix metallopeptidase 28",TRUE
+"205828_at",0.671160592618559,0.137006371727768,1.54294799494143,-4.84223445345305,1.1457657160658,"MMP3","matrix metallopeptidase 3",TRUE
+"204259_at",0.607377668936197,0.080983689191493,1.82840963080036,-4.43066428785477,1.50795348410493,"MMP7","matrix metallopeptidase 7",TRUE
+"231688_at",0.619281048427601,0.0894838643655086,1.77591647808323,-4.51024223377363,1.51592942179773,"MMP8","matrix metallopeptidase 8",TRUE
+"207329_at",0.969882914559333,0.856451420610152,-0.183013937699329,-5.92338289389876,-0.140924031314048,"MMP8","matrix metallopeptidase 8",TRUE
+"203936_s_at",0.391240007651669,0.0131601395239777,2.6955656132878,-2.91086273462332,1.06899624489539,"MMP9","matrix metallopeptidase 9",TRUE
+"205612_at",0.841550580403629,0.433103607125529,-0.798417026288745,-5.63387547078916,-0.739274568733936,"MMRN1","multimerin 1",TRUE
+"219091_s_at",0.685081687780732,0.153504016855802,1.47792192909048,-4.92837292933333,0.958028978018437,"MMRN2","multimerin 2",TRUE
+"236262_at",0.695439932196858,0.164927386878986,1.43615693619329,-4.98211770334903,0.847120564631137,"MMRN2","multimerin 2",TRUE
+"222822_s_at",0.739367922105944,0.227303350212316,1.24177795491256,-5.2153004858526,0.741824694593613,"MMRN2","multimerin 2",TRUE
+"202167_s_at",0.901154557823402,0.597531176746543,0.535658357462781,-5.80088859436974,0.159692889708888,"MMS19","MMS19 homolog, cytosolic iron-sulfur assembly component",TRUE
+"205330_at",0.462241397168626,0.0233086334155263,2.43665488067344,-3.39969832004526,1.86016694675162,"MN1","MN1 proto-oncogene, transcriptional regulator",TRUE
+"203565_s_at",0.834110449220514,0.411964538891932,-0.836210106292326,-5.60472667287906,-0.31682878085042,"MNAT1","MNAT1, CDK activating kinase assembly factor",TRUE
+"223700_at",0.812432515576345,0.360981201637334,-0.932792773641283,-5.52454830962967,-0.48470908145848,"MND1","meiotic nuclear divisions 1",TRUE
+"204959_at",0.812896635201594,0.361764846783714,0.931242346673359,-5.5258992438842,0.77488753337228,"MNDA","myeloid cell nuclear differentiation antigen",TRUE
+"219703_at",0.610033432202476,0.0822721001529723,1.82015534323871,-4.44328846399512,0.957667470546404,"MNS1","meiosis specific nuclear structural 1",TRUE
+"236749_at",0.715119690416591,0.190837169759021,1.34939837498782,-5.08970279508031,0.715339142252839,"MNT","MAX network transcriptional repressor",TRUE
+"204206_at",0.768852835478002,0.273488100259629,1.12293024462377,-5.343492241006,0.374803052333695,"MNT","MAX network transcriptional repressor",TRUE
+"214614_at",0.734614760371776,0.219249083854534,-1.26433387994644,-5.18971325321329,-0.952129323011352,"MNX1","motor neuron and pancreas homeobox 1",TRUE
+"236967_at",0.605664606439963,0.079162882423659,-1.84027118772565,-4.41245145180139,-2.09244778289262,"MNX1-AS1","MNX1 antisense RNA 1 (head to head)",TRUE
+"212508_at",0.462049949204478,0.0232531301326523,-2.43775535914069,-3.39767483194721,-1.13740167772006,"MOAP1","modulator of apoptosis 1",TRUE
+"201299_s_at",0.411110107932987,0.016066306647414,2.60624882263309,-3.08226754408328,0.687703244818938,"MOB1A","MOB kinase activator 1A",TRUE
+"201298_s_at",0.687734660055697,0.157018788420409,1.46481112364205,-4.9453790053803,0.481621627906009,"MOB1A","MOB kinase activator 1A",TRUE
+"214812_s_at",0.692209287833119,0.161559812017164,1.44821960627411,-4.96672366635874,0.353983802521434,"MOB1A","MOB kinase activator 1A",TRUE
+"201297_s_at",0.755940660414394,0.250642806727332,1.17967089087695,-5.28369398677883,0.309024621851545,"MOB1A","MOB kinase activator 1A",TRUE
+"225997_at",0.998347572104896,0.99295665951522,0.00892777473005493,-5.93964465937813,0.00554274259885368,"MOB1B","MOB kinase activator 1B",TRUE
+"223353_at",0.99739139970986,0.986847417468758,0.0166721102315895,-5.93954809794885,0.00469443289720672,"MOB2","MOB kinase activator 2",TRUE
+"225530_at",0.731548533938014,0.2148206258067,-1.27700758667148,-5.17516339984694,-0.445882949054266,"MOB3A","MOB kinase activator 3A",TRUE
+"235163_at",0.962555471240652,0.829535901439433,-0.217855071818024,-5.91659346154764,-0.14394147184452,"MOB3A","MOB kinase activator 3A",TRUE
+"229568_at",0.51531387545335,0.0357043127619446,2.23648371009272,-3.75911697211674,2.12271246043849,"MOB3B","MOB kinase activator 3B",TRUE
+"226844_at",0.560295667354693,0.0542789436302155,2.03231917803102,-4.10625228498101,1.30791442884374,"MOB3B","MOB kinase activator 3B",TRUE
+"219265_at",0.646692716816097,0.117739635462699,1.62763954372078,-4.72567685668454,0.728106930806216,"MOB3B","MOB kinase activator 3B",TRUE
+"1563521_at",0.856257656023992,0.469767388188473,0.735470556560647,-5.67960209056095,0.310826670191757,"MOB3B","MOB kinase activator 3B",TRUE
+"227066_at",0.358427723880268,0.0101857657154546,2.80881241987609,-2.68975344630298,1.09989074464301,"MOB3C","MOB kinase activator 3C",TRUE
+"243052_at",0.47853043092175,0.0266769227882852,2.37403167601361,-3.51401794095566,0.977924318208945,"MOB3C","MOB kinase activator 3C",TRUE
+"202919_at",0.640067422642767,0.110553678199517,-1.66221620554143,-4.67670881307131,-0.536120278502068,"MOB4","MOB family member 4, phocein",TRUE
+"241717_at",0.637812558837132,0.109142648385555,-1.66922707551875,-4.66668414441895,-0.76521650934785,"MOBP","myelin-associated oligodendrocyte basic protein",TRUE
+"242765_at",0.675118548055585,0.141296416010975,1.52544623045846,-4.86570956193394,0.507851544257771,"MOBP","myelin-associated oligodendrocyte basic protein",TRUE
+"210193_at",0.871451481476429,0.512613122674303,-0.66547870304215,-5.72625355806918,-0.404046489276825,"MOBP","myelin-associated oligodendrocyte basic protein",TRUE
+"235794_at",0.946318134613249,0.757019891572278,-0.313250775978779,-5.89200258830327,-0.200901902091297,"MOBP","myelin-associated oligodendrocyte basic protein",TRUE
+"207659_s_at",0.95825706371645,0.811210392210625,0.241732879672964,-5.91126206163213,0.115392895027665,"MOBP","myelin-associated oligodendrocyte basic protein",TRUE
+"219959_at",0.254596096102436,0.00362744140583077,3.25247368512029,-1.7901039019067,1.68451410991228,"MOCOS","molybdenum cofactor sulfurase",TRUE
+"238576_at",0.696440263939453,0.1664165846529,1.43088576232195,-4.9888115989855,0.753651777319351,"MOCOS","molybdenum cofactor sulfurase",TRUE
+"1555127_at",0.643688366500038,0.11466703167174,-1.64220053187579,-4.70515147521376,-1.0320433989055,"MOCS1","molybdenum cofactor synthesis 1",TRUE
+"211673_s_at",0.740610299769501,0.230041663377229,1.23424829629658,-5.22375387535361,0.349753406540113,"MOCS1","molybdenum cofactor synthesis 1",TRUE
+"213181_s_at",0.790240875783718,0.319592889533682,-1.01815688593674,-5.44700491768069,-0.948669036242758,"MOCS1","molybdenum cofactor synthesis 1",TRUE
+"218212_s_at",0.867717011547419,0.500681663396914,-0.684622356436705,-5.7139359407213,-0.30963676540606,"MOCS2","molybdenum cofactor synthesis 2",TRUE
+"236208_at",0.940573871932083,0.734051890541234,-0.344050778596795,-5.88219324426404,-0.184801381044897,"MOCS2","molybdenum cofactor synthesis 2",TRUE
+"206141_at",0.668407131834285,0.134561633289437,-1.55312454656404,-4.82848720784224,-0.63264689828404,"MOCS3","molybdenum cofactor synthesis 3",TRUE
+"205989_s_at",0.687734660055697,0.157081489433481,1.46457940591103,-4.94567846409099,1.256234557075,"MOG","myelin oligodendrocyte glycoprotein",TRUE
+"214650_x_at",0.859808651386477,0.47811179566718,-0.721558725367977,-5.68922819224636,-0.305014465705083,"MOG","myelin oligodendrocyte glycoprotein",TRUE
+"211836_s_at",0.951810226174863,0.779261276256793,0.283717341458131,-5.90055294827479,0.158934450711326,"MOG","myelin oligodendrocyte glycoprotein",TRUE
+"1555807_a_at",0.957105919915331,0.805754520124056,0.248868982459618,-5.90956179388235,0.18401778842045,"MOG","myelin oligodendrocyte glycoprotein",TRUE
+"1553062_at",0.627021415091472,0.0976401827166351,1.72943766903421,-4.57928286819881,0.618492308800602,"MOGAT1","monoacylglycerol O-acyltransferase 1",TRUE
+"207491_at",0.710842845257879,0.184394577531938,1.37005292664967,-5.06459440549599,0.851364787802862,"MOGAT2","monoacylglycerol O-acyltransferase 2",TRUE
+"232428_at",0.928390310707044,0.685557026145152,-0.410257557681305,-5.85803611044879,-0.340434353906346,"MOGAT2","monoacylglycerol O-acyltransferase 2",TRUE
+"234850_at",0.610660880283135,0.0833218138517184,1.81351267008879,-4.45341795815719,1.10934113458981,"MOGAT3","monoacylglycerol O-acyltransferase 3",TRUE
+"210627_s_at",0.763356510523603,0.26306032524787,1.14837747259155,-5.31699421622572,0.265567784437584,"MOGS","mannosyl-oligosaccharide glucosidase",TRUE
+"205130_at",0.680330645682834,0.147513851020942,1.50084000509924,-4.89835266906283,1.13318655430125,"MOK","MOK protein kinase",TRUE
+"224500_s_at",0.812302873476553,0.360466737460216,-0.93381185846577,-5.52365922498851,-0.340534830482873,"MON1A","MON1 homolog A, secretory trafficking associated",TRUE
+"203644_s_at",0.927041268353741,0.68133384882725,0.416108076284225,-5.85570055081618,0.19069518098088,"MON1B","MON1 homolog B, secretory trafficking associated",TRUE
+"227116_at",0.942303845415102,0.740328434983447,-0.335601482045768,-5.88497475522004,-0.15466187687035,"MON1B","MON1 homolog B, secretory trafficking associated",TRUE
+"233557_s_at",0.993225426079816,0.967863491663985,0.0407457931361102,-5.93887488131706,0.0146399956779533,"MON1B","MON1 homolog B, secretory trafficking associated",TRUE
+"237332_at",0.571355729481463,0.059189005062332,-1.988996755197,-4.17713205886914,-1.60401598207115,"MON2","MON2 homolog, regulator of endosome-to-Golgi trafficking",TRUE
+"212754_s_at",0.587626678796111,0.0668092928970177,-1.92768987318352,-4.27566723764223,-0.666764237043408,"MON2","MON2 homolog, regulator of endosome-to-Golgi trafficking",TRUE
+"212755_at",0.724590981430178,0.201809515237328,-1.31544957030023,-5.13027649561955,-0.545457178931873,"MON2","MON2 homolog, regulator of endosome-to-Golgi trafficking",TRUE
+"224277_at",0.998544717385199,0.99383279169548,0.00781720949373914,-5.93965371696691,0.00490851805760806,"MOP-1","MOP-1",TRUE
+"220850_at",0.819018525257656,0.374580770715321,-0.906198250260624,-5.54743408109635,-0.970714407463565,"MORC1","MORC family CW-type zinc finger 1",TRUE
+"228449_at",0.660234446131062,0.128283271120201,-1.57997766153518,-4.79187081122594,-1.1404316645861,"MORC2","MORC family CW-type zinc finger 2",TRUE
+"216863_s_at",0.868361060481977,0.502856521492144,-0.681113876171096,-5.71621841185711,-0.247324627315384,"MORC2","MORC family CW-type zinc finger 2",TRUE
+"203956_at",0.886567073863495,0.549492801545507,-0.607810830840952,-5.76133015442692,-0.234259776232559,"MORC2","MORC family CW-type zinc finger 2",TRUE
+"230566_at",0.800151005845581,0.335660968817087,-0.98416306126976,-5.47862518589465,-0.303321714204767,"MORC2-AS1","MORC2 antisense RNA 1",TRUE
+"213000_at",0.687734660055697,0.157014138051786,1.46482831251999,-4.94535678993038,0.485756384149553,"MORC3","MORC family CW-type zinc finger 3",TRUE
+"219038_at",0.71242055183987,0.186586082713226,-1.36296407799203,-5.07324772186764,-0.699599993944688,"MORC4","MORC family CW-type zinc finger 4",TRUE
+"221381_s_at",0.660460734341314,0.128476816096569,-1.57913374170953,-4.79302905507411,-0.569398976182406,"MORF4L1","mortality factor 4 like 1",TRUE
+"224561_s_at",0.76150249762201,0.260617004764573,-1.15444702807094,-5.31059682779948,-0.347511177622275,"MORF4L1","mortality factor 4 like 1",TRUE
+"217982_s_at",0.763960948570373,0.263906065937446,-1.14628622730252,-5.31919154534642,-0.310597783134142,"MORF4L1","mortality factor 4 like 1",TRUE
+"201994_at",0.90360437116293,0.604761218629189,-0.525052784231751,-5.8062944315443,-0.119920993791906,"MORF4L2","mortality factor 4 like 2",TRUE
+"243683_at",0.990193700926546,0.951346595512966,-0.0617105961064806,-5.93782881827852,-0.0382888338054954,"MORF4L2","mortality factor 4 like 2",TRUE
+"243857_at",0.992490513431419,0.965025709648671,-0.044346175139469,-5.93872567594849,-0.0230065625098685,"MORF4L2","mortality factor 4 like 2",TRUE
+"1559002_at",0.910327933615304,0.627254789110543,0.492436874774231,-5.82225877500079,0.184441286574539,"MORF4L2-AS1","MORF4L2 antisense RNA 1",TRUE
+"231088_at",0.913627134030439,0.637887552254942,0.477207868990524,-5.82937045785254,0.360280816001047,"MORF4L2-AS1","MORF4L2 antisense RNA 1",TRUE
+"219852_s_at",0.626492205553783,0.097144964219204,1.73216300027168,-4.57527201401141,0.696217711650371,"MORN1","MORN repeat containing 1",TRUE
+"1554268_at",0.8877101263145,0.552823815105302,-0.60270584123212,-5.76428776741585,-0.194066520146768,"MORN1","MORN repeat containing 1",TRUE
+"222933_at",0.939552398787723,0.729096098322186,0.350740174129611,-5.87994260298663,0.192210674727162,"MORN1","MORN repeat containing 1",TRUE
+"1563668_at",0.975252543936228,0.879948029217412,0.15278839076198,-5.92831972882482,0.0649415346810542,"MORN1","MORN repeat containing 1",TRUE
+"226790_at",0.769258076576208,0.276331515816608,1.11611493959027,-5.35049986160161,0.342481980396174,"MORN2","MORN repeat containing 2",TRUE
+"237211_x_at",0.700061364939874,0.17171003844083,1.41245028356898,-5.01206417021503,0.758243841698688,"MORN3","MORN repeat containing 3",TRUE
+"228354_at",0.636147339487472,0.107526633060596,1.67735115905214,-4.65502765724028,0.758035715903056,"MORN4","MORN repeat containing 4",TRUE
+"236813_at",0.969859842767097,0.855887556080995,0.183741314023538,-5.9232531707897,0.120745061938432,"MORN4","MORN repeat containing 4",TRUE
+"229976_at",0.278117437243239,0.00447633003701966,-3.16347192160352,-1.97420479955952,-1.82354447313412,"MORN5","MORN repeat containing 5",TRUE
+"221367_at",0.967701855457407,0.848206641063208,-0.193659857475153,-5.92143308825126,-0.051258066705751,"MOS","v-mos Moloney murine sarcoma viral oncogene homolog",TRUE
+"218853_s_at",0.7768734672127,0.294644139420889,-1.07339866789621,-5.39355712739347,-0.528716121118183,"MOSPD1","motile sperm domain containing 1",TRUE
+"1557455_s_at",0.866667221107408,0.497937237886657,-0.689062012887981,-5.7110316239107,-0.375443858290867,"MOSPD1","motile sperm domain containing 1",TRUE
+"64883_at",0.820442898002464,0.379508327637517,0.896720329284171,-5.55544256046939,0.251172293818462,"MOSPD2","motile sperm domain containing 2",TRUE
+"221895_at",0.940573871932083,0.734008929215359,0.344108699215628,-5.88217394078801,0.100488084268791,"MOSPD2","motile sperm domain containing 2",TRUE
+"219070_s_at",0.849476567070666,0.450602928427527,-0.767986884884492,-5.65642370010531,-0.238267635438175,"MOSPD3","motile sperm domain containing 3",TRUE
+"233917_s_at",0.94149227422279,0.738396391220734,0.33819965970918,-5.88412671662137,0.134207093833462,"MOV10","Mov10 RISC complex RNA helicase",TRUE
+"223849_s_at",0.97589003385521,0.884593847005229,-0.146830231503763,-5.92918828200977,-0.0734990030597285,"MOV10","Mov10 RISC complex RNA helicase",TRUE
+"239257_at",0.819807973515613,0.377798025306901,0.900000776616215,-5.55267951612337,0.516431049852212,"MOV10L1","Mov10 RISC complex RNA helicase like 1",TRUE
+"224385_s_at",0.8920930097751,0.56341518393208,0.586579767456492,-5.77347219201188,0.382483118999397,"MOV10L1","Mov10 RISC complex RNA helicase like 1",TRUE
+"209708_at",0.539114280228505,0.0441910894625158,2.13359121584098,-3.93668401882673,1.70588326626385,"MOXD1","monooxygenase DBH like 1",TRUE
+"1554474_a_at",0.545085128927207,0.046906627411062,2.10443820500533,-3.9860410912138,1.46964967600539,"MOXD1","monooxygenase DBH like 1",TRUE
+"243697_at",0.750020866111355,0.242881494361807,1.19982155246056,-5.26183745149636,0.954406386391733,"MOXD1","monooxygenase DBH like 1",TRUE
+"218024_at",0.514646418668119,0.0347898578827831,-2.24886567068988,-3.73740599641896,-1.05510198605588,"MPC1","mitochondrial pyruvate carrier 1",TRUE
+"240362_at",0.934867348047609,0.710716988387489,-0.375694431641713,-5.87116917433942,-0.317303575104532,"MPC1","mitochondrial pyruvate carrier 1",TRUE
+"227669_at",0.362885168249175,0.0104928117858561,-2.79576147578848,-2.71543862445862,-1.47278208006307,"MPC2","mitochondrial pyruvate carrier 2",TRUE
+"202427_s_at",0.398934416346185,0.0140416219665328,-2.6666577199715,-2.96663860628972,-1.00981209471709,"MPC2","mitochondrial pyruvate carrier 2",TRUE
+"1557569_at",0.841967750949524,0.434653260868583,0.795692168272951,-5.63592816737005,0.435682478122105,"MPDU1","mannose-P-dolichol utilization defect 1",TRUE
+"209208_at",0.983661414460339,0.920296887679739,0.10120640213927,-5.93469585286426,0.0324226125597118,"MPDU1","mannose-P-dolichol utilization defect 1",TRUE
+"205079_s_at",0.936143408699214,0.714907266628362,0.369984233886158,-5.87322926664377,0.16324230114664,"MPDZ","multiple PDZ domain crumbs cell polarity complex component",TRUE
+"213306_at",0.975398143273847,0.881475794110161,0.150828451649948,-5.92860924411282,0.0830967721505615,"MPDZ","multiple PDZ domain crumbs cell polarity complex component",TRUE
+"226841_at",0.476975940760709,0.0264506822567256,2.37800218118973,-3.50681874562327,1.64832049083715,"MPEG1","macrophage expressed 1",TRUE
+"226818_at",0.683017520100356,0.151482027254045,1.48557522162682,-4.91838927558859,0.857352385222579,"MPEG1","macrophage expressed 1",TRUE
+"203686_at",0.61591966964196,0.0870166195690519,-1.79069321977544,-4.48801136021312,-0.844046121435202,"MPG","N-methylpurine DNA glycosylase",TRUE
+"212885_at",0.984244246588495,0.923241466443339,0.0974547665672282,-5.93505869049601,0.0258860235525376,"MPHOSPH10","M-phase phosphoprotein 10",TRUE
+"1554906_a_at",0.592488489935347,0.0694604692963666,-1.90780198202989,-4.30717587568583,-0.870836737051168,"MPHOSPH6","M-phase phosphoprotein 6",TRUE
+"203740_at",0.914242258486146,0.63951164450529,-0.474891862825819,-5.83043285336561,-0.207065583927051,"MPHOSPH6","M-phase phosphoprotein 6",TRUE
+"221771_s_at",0.697699759202153,0.16850709319185,-1.42354975358137,-4.9980940966027,-0.541508953674116,"MPHOSPH8","M-phase phosphoprotein 8",TRUE
+"227026_at",0.724970327905974,0.202957925583012,-1.31198039131252,-5.1343735851018,-0.495599294598131,"MPHOSPH8","M-phase phosphoprotein 8",TRUE
+"240942_at",0.931701709230955,0.698516410847482,-0.392393985119088,-5.86496588317554,-0.317019436752761,"MPHOSPH8","M-phase phosphoprotein 8",TRUE
+"225041_at",0.942684843065067,0.743300818623022,-0.331608862117144,-5.88626532579372,-0.13272861525021,"MPHOSPH8","M-phase phosphoprotein 8",TRUE
+"215731_s_at",0.939452234779565,0.72886168387047,-0.351056991923069,-5.87983494761281,-0.188521047693617,"MPHOSPH9","M-phase phosphoprotein 9",TRUE
+"1558369_at",0.943464796017993,0.747075424770565,0.326546568100421,-5.88787968179938,0.12988323869744,"MPHOSPH9","M-phase phosphoprotein 9",TRUE
+"237158_s_at",0.957504800422796,0.808261893990184,0.245587801622322,-5.91034968448846,0.0824338893608356,"MPHOSPH9","M-phase phosphoprotein 9",TRUE
+"206205_at",0.959584210327095,0.817462598797804,-0.233570921835218,-5.91314644697634,-0.0816281790621858,"MPHOSPH9","M-phase phosphoprotein 9",TRUE
+"202472_at",0.645072069975909,0.115460206138326,-1.63841061578779,-4.71050731177781,-0.570132080710369,"MPI","mannose phosphate isomerase",TRUE
+"230524_at",0.921006039723366,0.663831653665286,-0.44051551847859,-5.84560641225735,-0.133320168790744,"MPI","mannose phosphate isomerase",TRUE
+"207550_at",0.61299046462692,0.0845581319689356,1.80578139776135,-4.46517379712107,1.49682917889364,"MPL","MPL proto-oncogene, thrombopoietin receptor",TRUE
+"211903_s_at",0.863468033337798,0.488153578609444,-0.705003692733892,-5.7004553060064,-0.527534051871912,"MPL","MPL proto-oncogene, thrombopoietin receptor",TRUE
+"216825_s_at",0.955816406528307,0.798825423407325,-0.257951146067962,-5.90732675229201,-0.104374622944076,"MPL","MPL proto-oncogene, thrombopoietin receptor",TRUE
+"225419_at",0.966593471043185,0.844787771325832,-0.19808106388129,-5.92059106816141,-0.0717968508002951,"MPLKIP","M-phase specific PLK1 interacting protein",TRUE
+"233651_s_at",0.954577684533304,0.792590628291312,-0.266142240178833,-5.90524274045012,-0.152975649214998,"MPND","MPN domain containing",TRUE
+"203949_at",0.411110107932987,0.0162666615027585,2.60066608799224,-3.09288855401945,0.721275580485572,"MPO","myeloperoxidase",TRUE
+"203948_s_at",0.8920930097751,0.564266358052807,-0.585290642093348,-5.77419600312248,-0.422198244905482,"MPO","myeloperoxidase",TRUE
+"202974_at",0.768852835478002,0.273227463260575,1.12355754232696,-5.34284534492424,1.07247568936482,"MPP1","membrane palmitoylated protein 1",TRUE
+"213270_at",0.93032716386748,0.691918969382661,0.401471472956438,-5.86148242708071,0.290501831831715,"MPP2","membrane palmitoylated protein 2",TRUE
+"207984_s_at",0.986342822130003,0.933282161414689,0.0846725263305796,-5.9361921156707,0.0607106504915418,"MPP2","membrane palmitoylated protein 2",TRUE
+"206186_at",0.952293443370532,0.781547688966106,0.280696310613911,-5.90138026842361,0.15957961634893,"MPP3","membrane palmitoylated protein 3",TRUE
+"1552489_s_at",0.979803152416153,0.903826781164728,0.122219719164332,-5.93241051538996,0.111981508566819,"MPP4","membrane palmitoylated protein 4",TRUE
+"1555099_at",0.991689960875868,0.960839133758727,-0.0496589249915619,-5.93848245014351,-0.0465491711253305,"MPP4","membrane palmitoylated protein 4",TRUE
+"219321_at",0.903919439852106,0.605667479072847,0.52372772676123,-5.80696243965996,0.219340576837316,"MPP5","membrane palmitoylated protein 5",TRUE
+"226092_at",0.930065981387326,0.691285126277687,0.402345382054381,-5.86114292776286,0.146332518664922,"MPP5","membrane palmitoylated protein 5",TRUE
+"205429_s_at",0.698751793603048,0.170051968279509,1.41817524970798,-5.00486979854776,1.51898869820404,"MPP6","membrane palmitoylated protein 6",TRUE
+"1558522_at",0.748924337581408,0.242103177421935,1.2018688035885,-5.25959886495132,0.852489581045373,"MPP6","membrane palmitoylated protein 6",TRUE
+"1564308_a_at",0.787313843676753,0.313211950869923,-1.03198716829112,-5.43386235446502,-0.736065841816327,"MPP7","membrane palmitoylated protein 7",TRUE
+"237495_at",0.792436690618566,0.323862647887143,-1.00901001010913,-5.45560885126212,-0.749038144200562,"MPP7","membrane palmitoylated protein 7",TRUE
+"238778_at",0.937462538530338,0.722846240099371,-0.359199681329629,-5.87703509476938,-0.6049966169701,"MPP7","membrane palmitoylated protein 7",TRUE
+"238451_at",0.961212424803935,0.8231767457972,-0.226125551125189,-5.91480923860383,-0.33490677494662,"MPP7","membrane palmitoylated protein 7",TRUE
+"213727_x_at",0.881466832418197,0.538194872815388,0.625248717665813,-5.75104600362819,0.415504703598788,"MPPE1","metallophosphoesterase 1",TRUE
+"206764_x_at",0.916919564257648,0.648617618932827,-0.461954692634764,-5.83627429937623,-0.317386188162994,"MPPE1","metallophosphoesterase 1",TRUE
+"209858_x_at",0.985498770484702,0.929363093150049,0.0896598303737186,-5.93576879453469,0.0762685169052197,"MPPE1","metallophosphoesterase 1",TRUE
+"241398_at",0.673366993714442,0.13920316599222,1.53393045165453,-4.85435622235164,0.448233372019283,"MPPED1","metallophosphoesterase domain containing 1",TRUE
+"206436_at",0.895370220688938,0.573872128826748,-0.57081092853137,-5.78222007478535,-0.274095212138738,"MPPED1","metallophosphoesterase domain containing 1",TRUE
+"205413_at",0.67397614409571,0.140567921850618,-1.52838712299029,-4.86177981243573,-2.8076143955175,"MPPED2","metallophosphoesterase domain containing 2",TRUE
+"215692_s_at",0.726429285628433,0.205273570424495,-1.30503135997799,-5.14255284356917,-1.84837535028297,"MPPED2","metallophosphoesterase domain containing 2",TRUE
+"212197_x_at",0.34653510109471,0.00887332677700217,2.86918282966432,-2.57028519665076,1.27223436006093,"MPRIP","myosin phosphatase Rho interacting protein",TRUE
+"238328_at",0.354266150238033,0.00947949479283479,2.84031187998549,-2.62755104497892,2.25909841776016,"MPRIP","myosin phosphatase Rho interacting protein",TRUE
+"214771_x_at",0.380084968057051,0.0118179366336546,2.74330213189226,-2.81815441187836,1.1872045270584,"MPRIP","myosin phosphatase Rho interacting protein",TRUE
+"214694_at",0.535243600695458,0.0426359949520583,2.15102158868225,-3.90696892203063,0.828414863868855,"MPRIP","myosin phosphatase Rho interacting protein",TRUE
+"225896_at",0.632949074657601,0.103980226943101,1.69554859691675,-4.62876263298667,0.985079008179083,"MPRIP","myosin phosphatase Rho interacting protein",TRUE
+"231255_at",0.69910704334777,0.170400763411446,1.41696723430707,-5.00638986145401,0.447369756458212,"MPRIP","myosin phosphatase Rho interacting protein",TRUE
+"203524_s_at",0.768852835478002,0.273879048093936,-1.12199013494556,-5.34446112370213,-0.340515357389531,"MPST","mercaptopyruvate sulfurtransferase",TRUE
+"203466_at",0.895999830738594,0.576788212381433,0.566439649712593,-5.78460419199716,0.252957328782713,"MPV17","MPV17, mitochondrial inner membrane protein",TRUE
+"1559167_x_at",0.831957210365167,0.408130836718925,0.843194109099353,-5.5992020651591,0.321433101191232,"MPV17L","MPV17 mitochondrial inner membrane protein like",TRUE
+"1558686_at",0.987664725256051,0.941654994021901,-0.0740246805375872,-5.93701489603845,-0.0810235407144972,"MPV17L","MPV17 mitochondrial inner membrane protein like",TRUE
+"223473_at",0.862800800218883,0.486812535191644,-0.70720306685803,-5.6989780531368,-0.269021188013488,"MPV17L2","MPV17 mitochondrial inner membrane protein like 2",TRUE
+"210280_at",0.863739823286196,0.489332728069917,-0.70307270859075,-5.7017486739105,-0.353475286805732,"MPZ","myelin protein zero",TRUE
+"210210_at",0.821424121108148,0.38341296221169,0.889267261026637,-5.5616853984088,0.347495658592031,"MPZL1","myelin protein zero like 1",TRUE
+"231621_at",0.859483694145165,0.477047163338966,-0.723325714183144,-5.68801523321685,-0.358863113292164,"MPZL1","myelin protein zero like 1",TRUE
+"210594_x_at",0.867717011547419,0.500677765197436,0.684628652748065,-5.71393183452767,0.279729367968702,"MPZL1","myelin protein zero like 1",TRUE
+"210087_s_at",0.8913721384714,0.560777541225545,0.590580938704305,-5.77121582764494,0.222358255825952,"MPZL1","myelin protein zero like 1",TRUE
+"201874_at",0.957408588975217,0.807165046343166,0.247022808949014,-5.9100063836583,0.0787938488685267,"MPZL1","myelin protein zero like 1",TRUE
+"201875_s_at",0.986342822130003,0.93523720630313,-0.0821854176851614,-5.93639417606258,-0.0385247493742167,"MPZL1","myelin protein zero like 1",TRUE
+"230518_at",0.153726668922469,0.00114512460776242,3.73236992640042,-0.776060620253416,2.11288545981719,"MPZL2","myelin protein zero like 2",TRUE
+"203779_s_at",0.40150735038542,0.0144131955736563,2.65498181961334,-2.98908627341925,3.24640646897379,"MPZL2","myelin protein zero like 2",TRUE
+"203780_at",0.417001048339868,0.0170089080718411,2.58053122942647,-3.13110117078026,2.94269646045728,"MPZL2","myelin protein zero like 2",TRUE
+"1570585_at",0.624331975868069,0.0958308683393901,1.73945282694525,-4.56452057091185,1.63769692700982,"MPZL3","myelin protein zero like 3",TRUE
+"227747_at",0.812302873476553,0.360513079041435,0.933720022022056,-5.52373938283607,0.737491234256951,"MPZL3","myelin protein zero like 3",TRUE
+"1570584_at",0.907871409554181,0.617485817829238,0.506533454968333,-5.81548149125705,0.503603790399705,"MPZL3","myelin protein zero like 3",TRUE
+"210528_at",0.66909275739297,0.13518887387702,1.55049911259504,-4.83204067284398,1.17740626171588,"MR1","major histocompatibility complex, class I-related",TRUE
+"235352_at",0.807944276806637,0.349731299153384,0.955304440600114,-5.50470094204215,1.02142710055024,"MR1","major histocompatibility complex, class I-related",TRUE
+"207566_at",0.808233282592165,0.350302003087752,0.954150744450678,-5.50572863977103,0.647877712866499,"MR1","major histocompatibility complex, class I-related",TRUE
+"210223_s_at",0.919277283601704,0.656078991923587,-0.451413499484755,-5.84091703373572,-0.219335701449559,"MR1","major histocompatibility complex, class I-related",TRUE
+"210224_at",0.920780424288498,0.663130315258965,0.441499149096762,-5.84518777422903,0.215866834664725,"MR1","major histocompatibility complex, class I-related",TRUE
+"207565_s_at",0.946941640414848,0.759195135337204,-0.310350214513435,-5.89287947445141,-0.164247144257655,"MR1","major histocompatibility complex, class I-related",TRUE
+"1555740_a_at",0.861659105448003,0.482955919150782,0.713547690513862,-5.69469200541557,0.370131040784147,"MRAP","melanocortin 2 receptor accessory protein",TRUE
+"1555741_at",0.896118635245982,0.578273170098259,0.564217945440425,-5.78580911015571,0.31438479510963,"MRAP","melanocortin 2 receptor accessory protein",TRUE
+"1554044_a_at",0.998118426351368,0.991436920287453,0.0108541897556137,-5.93962609833143,0.00791039826725992,"MRAP","melanocortin 2 receptor accessory protein",TRUE
+"227226_at",0.937462538530338,0.722425084206528,0.359770692442954,-5.87683637407838,0.295662017316806,"MRAP2","melanocortin 2 receptor accessory protein 2",TRUE
+"225185_at",0.597844368220328,0.075141956989668,-1.86732956051476,-4.37059097311379,-1.44390959916742,"MRAS","muscle RAS oncogene homolog",TRUE
+"206538_at",0.851733415458562,0.456295263757817,-0.758243620359762,-5.6634684815638,-0.722376322051651,"MRAS","muscle RAS oncogene homolog",TRUE
+"204438_at",0.80861715520522,0.35174276507877,0.951243854485729,-5.50831301773285,0.734629685481035,"MRC1","mannose receptor, C type 1",TRUE
+"37408_at",0.51470556386048,0.0352638460588357,2.24241119865839,-3.74873246876429,1.36125764061689,"MRC2","mannose receptor C type 2",TRUE
+"209280_at",0.840118151712014,0.429117139878581,0.805454540485351,-5.62854344290043,0.444315842017521,"MRC2","mannose receptor C type 2",TRUE
+"211334_at",0.958640117088134,0.812553288982398,0.239978395106994,-5.91167255747654,0.208129146690566,"MRE11A","MRE11 homolog A, double strand break repair nuclease",TRUE
+"205395_s_at",0.980808506518944,0.90978443059106,-0.114612676103308,-5.93328741221448,-0.0536960949580845,"MRE11A","MRE11 homolog A, double strand break repair nuclease",TRUE
+"242456_at",0.989255418765878,0.947532090084138,0.0665560063958746,-5.937526166527,0.0317482771210473,"MRE11A","MRE11 homolog A, double strand break repair nuclease",TRUE
+"219648_at",0.673190784310977,0.138799844247081,-1.53557720876511,-4.85214678540025,-0.972781996167251,"MREG","melanoregulin",TRUE
+"232682_at",0.713633547141264,0.188534994871794,-1.35671496177074,-5.08084492486009,-0.886171222305041,"MREG","melanoregulin",TRUE
+"226091_s_at",0.529522722988603,0.0412888571371776,-2.16659163276979,-3.88029734761639,-0.522514193505224,"MRFAP1","Morf4 family associated protein 1",TRUE
+"212199_at",0.147686070612109,0.00103312413202246,-3.77472484955362,-0.685312415142087,-1.22061338718847,"MRFAP1L1","Morf4 family associated protein 1 like 1",TRUE
+"218586_at",0.954577684533304,0.792224587177712,-0.266623707519993,-5.90511823011462,-0.118612133303392,"MRGBP","MRG/MORF4L binding protein",TRUE
+"227727_at",0.567915942389722,0.057847091648941,2.00050977164939,-4.15839519207174,1.3088383417513,"MRGPRF","MAS related GPR family member F",TRUE
+"1560496_at",0.887291390477053,0.55171916601826,0.60439699021774,-5.76331065508423,0.357177081643711,"MRGPRF-AS1","MRGPRF antisense RNA 1",TRUE
+"1564439_a_at",0.861763798017736,0.48404779976689,-0.711748438942831,-5.69591117507176,-0.179332655428016,"MRGPRG-AS1","MRGPRG antisense RNA 1",TRUE
+"1553401_at",0.85334340854827,0.460391950394645,0.751276693552912,-5.6684536803329,0.258790222859006,"MRGPRX1","MAS related GPR family member X1",TRUE
+"1553889_at",0.845487921422997,0.442663592139689,-0.781701580549007,-5.64636354544733,-0.592098534587769,"MRGPRX2","MAS related GPR family member X2",TRUE
+"1553293_at",0.989586772349659,0.94930326338782,0.0643059615138785,-5.93766955038068,0.0479788830752321,"MRGPRX3","MAS related GPR family member X3",TRUE
+"1553504_at",0.952644489493803,0.783177454540286,0.278544534973145,-5.90196418007568,0.100207954798138,"MRGPRX4","MAS related GPR family member X4",TRUE
+"228077_at",0.958513463150671,0.811966834039239,0.240744499052909,-5.91149367825956,0.108631075541703,"MRI1","methylthioribose-1-phosphate isomerase 1",TRUE
+"223770_x_at",0.977490877064897,0.891961542709552,0.137392380900008,-5.93049353275512,0.0530480879075874,"MRI1","methylthioribose-1-phosphate isomerase 1",TRUE
+"231051_at",0.904832003218088,0.609540953387472,0.518074906528636,-5.80979375572246,0.180871175501213,"MRLN","myoregulin",TRUE
+"219967_at",0.909052380289506,0.622446289070271,0.499362700325185,-5.81895234391211,0.256422557875041,"MRM1","mitochondrial rRNA methyltransferase 1",TRUE
+"222130_s_at",0.910165867297668,0.626836684647347,0.493038109839913,-5.8219735294163,0.148807658328913,"MRM2","mitochondrial rRNA methyltransferase 2",TRUE
+"218356_at",0.940567117317801,0.73396510303184,-0.344167787075358,-5.88215424498985,-0.10291311574173,"MRM2","mitochondrial rRNA methyltransferase 2",TRUE
+"218993_at",0.990519877107938,0.952047324092939,-0.060820657336142,-5.93788192062247,-0.0191232397926253,"MRM3","mitochondrial rRNA methyltransferase 3",TRUE
+"224323_s_at",0.729083413548563,0.211015686847975,1.28805859369499,-5.16237549395482,0.452618777739531,"MRO","maestro",TRUE
+"224324_at",0.896428361916712,0.580859527039284,0.56035522547489,-5.78789308244382,0.291520227452353,"MRO","maestro",TRUE
+"231358_at",0.932091525948902,0.700074809358908,-0.390254687855088,-5.86577540410826,-0.285490994996296,"MRO","maestro",TRUE
+"232498_at",0.730048787941067,0.212474760987234,1.28380284313013,-5.16731123574923,1.15128696564603,"MROH1","maestro heat like repeat family member 1",TRUE
+"230361_at",0.739367922105944,0.227262631847143,1.241890439775,-5.21517386592654,0.73194053767344,"MROH1","maestro heat like repeat family member 1",TRUE
+"227778_at",0.747587302711183,0.239458624434944,1.20886212612475,-5.2519269582865,0.825677366119367,"MROH1","maestro heat like repeat family member 1",TRUE
+"1565653_at",0.937113154905832,0.720809202030473,0.36196266935994,-5.87607063722435,0.211026376880605,"MROH1","maestro heat like repeat family member 1",TRUE
+"1556168_s_at",0.626839388794963,0.0973380471734546,-1.73109900049508,-4.57683845511228,-1.34157579473463,"MROH2A","maestro heat like repeat family member 2A",TRUE
+"1556167_at",0.903021267024792,0.602926554921886,0.527738193857904,-5.80493558164151,0.44203924511075,"MROH2A","maestro heat like repeat family member 2A",TRUE
+"240411_at",0.600637035974564,0.0766354634285973,1.85713520782722,-4.38641302374005,1.27403336950962,"MROH2B","maestro heat like repeat family member 2B",TRUE
+"1569730_at",0.877861946695164,0.529382464462483,0.638986899201415,-5.74274658671823,0.254988737747075,"MROH2B","maestro heat like repeat family member 2B",TRUE
+"240412_s_at",0.986889306520757,0.939451446468998,0.076826060524578,-5.93680912435361,0.0535987162445206,"MROH2B","maestro heat like repeat family member 2B",TRUE
+"227672_at",0.51531387545335,0.0358925267113509,2.23397115654836,-3.76351378469067,1.06207414309831,"MROH6","maestro heat like repeat family member 6",TRUE
+"214147_at",0.974982245454858,0.878484252053228,0.154666816165537,-5.92803875451859,0.0480976339059875,"MROH7","maestro heat like repeat family member 7",TRUE
+"46167_at",0.970190697775564,0.858416921730054,-0.180479259452801,-5.92383093039171,-0.0653044287415074,"MROH7-TTC4///TTC4","MROH7-TTC4 readthrough (NMD candidate)///tetratricopeptide repeat domain 4",TRUE
+"232185_at",0.591331966259927,0.0686542472516094,-1.91377830177981,-4.2977313328994,-1.20806792887979,"MROH8","maestro heat like repeat family member 8",TRUE
+"236618_at",0.896124365232644,0.578502159949728,0.563875600110828,-5.78599436929611,0.466665660773487,"MROH8","maestro heat like repeat family member 8",TRUE
+"221182_at",0.682125064335234,0.149675280710474,1.49248447924307,-4.90934055223982,1.30218366178388,"MROH9","maestro heat like repeat family member 9",TRUE
+"223154_at",0.950887541143339,0.77560430494222,0.288554911967472,-5.899209860893,0.0855804834320768,"MRPL1","mitochondrial ribosomal protein L1",TRUE
+"224671_at",0.898834548364114,0.588816772176634,-0.548524592584245,-5.79418935978446,-0.214063716647669,"MRPL10","mitochondrial ribosomal protein L10",TRUE
+"219162_s_at",0.790309297261437,0.319912949649711,1.0174682904117,-5.4476550845821,0.351012463830731,"MRPL11","mitochondrial ribosomal protein L11",TRUE
+"203931_s_at",0.56861088242915,0.0582399514595819,-1.99711488306933,-4.1639277508045,-0.70637066978723,"MRPL12","mitochondrial ribosomal protein L12",TRUE
+"229165_at",0.784708646973769,0.308643158047562,1.04201193889096,-5.42423614254599,0.530132414026208,"MRPL12","mitochondrial ribosomal protein L12",TRUE
+"218049_s_at",0.958151088213963,0.810998007505547,-0.242010429604067,-5.9111968510209,-0.0853394750345,"MRPL13","mitochondrial ribosomal protein L13",TRUE
+"225201_s_at",0.990810941805126,0.954059733896564,0.0582651354540754,-5.93803012142996,0.0219346108914671,"MRPL14","mitochondrial ribosomal protein L14",TRUE
+"218027_at",0.956960361976289,0.804806897654999,-0.250109778590393,-5.90926114021379,-0.103251386644775,"MRPL15","mitochondrial ribosomal protein L15",TRUE
+"217980_s_at",0.73223722457785,0.216405456198242,-1.27244910783666,-5.18041096461388,-0.382408218903011,"MRPL16","mitochondrial ribosomal protein L16",TRUE
+"222216_s_at",0.997288583476358,0.986188287450092,-0.0175077053571297,-5.93953418738443,-0.00546279421235063,"MRPL17","mitochondrial ribosomal protein L17",TRUE
+"217907_at",0.864894115958506,0.493427520435793,0.696387738174552,-5.70620011944258,0.25046341645157,"MRPL18","mitochondrial ribosomal protein L18",TRUE
+"238448_at",0.511967403040634,0.0341967070124261,-2.25705679146365,-3.72300401612073,-0.816097269913422,"MRPL19","mitochondrial ribosomal protein L19",TRUE
+"232071_at",0.698480416742743,0.169806886000269,-1.41902525416691,-5.00379958824261,-0.849420425846787,"MRPL19","mitochondrial ribosomal protein L19",TRUE
+"203465_at",0.739340500562926,0.22659458196647,-1.24373813045706,-5.21309257880086,-0.436082673080277,"MRPL19","mitochondrial ribosomal protein L19",TRUE
+"229884_s_at",0.818247708976668,0.371245130337401,0.912661029171843,-5.54192869846443,0.280808244659193,"MRPL2","mitochondrial ribosomal protein L2",TRUE
+"218887_at",0.861388867330702,0.481949354759186,0.715208447118442,-5.69356407927281,0.31526815649206,"MRPL2","mitochondrial ribosomal protein L2",TRUE
+"220527_at",0.734320804572117,0.218654925960762,1.26602279532757,-5.18778148389081,1.16158248491192,"MRPL20","mitochondrial ribosomal protein L20",TRUE
+"220526_s_at",0.758081075834994,0.254935134023684,-1.16872620716781,-5.29542971763541,-0.291697231243116,"MRPL20","mitochondrial ribosomal protein L20",TRUE
+"224803_s_at",0.957571530817866,0.80929168590041,0.24424100306175,-5.91067007393623,0.154006279861518,"MRPL20","mitochondrial ribosomal protein L20",TRUE
+"225315_at",0.979588787486838,0.901975483309328,-0.124585038153457,-5.93212639015375,-0.0650373047090671,"MRPL21","mitochondrial ribosomal protein L21",TRUE
+"218339_at",0.708894565317004,0.181445480758461,-1.37969832528545,-5.05276036297179,-0.436793162646284,"MRPL22","mitochondrial ribosomal protein L22",TRUE
+"213897_s_at",0.627092759817312,0.0982807897600252,-1.72592967682599,-4.58443864154015,-0.577769372167554,"MRPL23","mitochondrial ribosomal protein L23",TRUE
+"1562392_at",0.682539393883246,0.150334713349922,1.48995488006772,-4.91265736634112,0.827630792188752,"MRPL23","mitochondrial ribosomal protein L23",TRUE
+"218270_at",0.627092759817312,0.0987064202315431,-1.72360968035005,-4.58784410732822,-0.597413473597683,"MRPL24","mitochondrial ribosomal protein L24",TRUE
+"224330_s_at",0.712975827977365,0.187411706872475,-1.36031048705113,-5.0764773166758,-0.541834066529393,"MRPL27","mitochondrial ribosomal protein L27",TRUE
+"204599_s_at",0.93174221209471,0.69866652758232,-0.392187830836016,-5.86504408285377,-0.111331456134245,"MRPL28","mitochondrial ribosomal protein L28",TRUE
+"208787_at",0.896118635245982,0.577881737383766,-0.564803304594829,-5.78549209221497,-0.146101047786914,"MRPL3","mitochondrial ribosomal protein L3",TRUE
+"224971_at",0.702555849237924,0.173946017944834,-1.40479951547971,-5.02164123521472,-0.385468110237907,"MRPL30","mitochondrial ribosomal protein L30",TRUE
+"224173_s_at",0.807963535598932,0.349785036810731,-0.955195753790727,-5.50479780735888,-0.337191393491086,"MRPL30","mitochondrial ribosomal protein L30",TRUE
+"223996_s_at",0.857381762624307,0.472852345043037,-0.73031050802487,-5.68319288618747,-0.216881052411278,"MRPL30","mitochondrial ribosomal protein L30",TRUE
+"243887_at",0.858826390511142,0.474975431906336,-0.726770831393538,-5.68564220530256,-0.25214122543712,"MRPL30","mitochondrial ribosomal protein L30",TRUE
+"243801_x_at",0.978257169730337,0.895136640845067,-0.133329140593462,-5.93102883254168,-0.0396274135748804,"MRPL30","mitochondrial ribosomal protein L30",TRUE
+"225260_s_at",0.819018525257656,0.374056035846327,-0.907212388932276,-5.54657256602169,-0.235915583613973,"MRPL32","mitochondrial ribosomal protein L32",TRUE
+"203781_at",0.384135218769668,0.0124213606778983,2.72123820548321,-2.86109642232369,0.967979073429563,"MRPL33","mitochondrial ribosomal protein L33",TRUE
+"221692_s_at",0.729273475042162,0.211752734222411,-1.2859059817868,-5.16487379133644,-0.481612989239752,"MRPL34","mitochondrial ribosomal protein L34",TRUE
+"225255_at",0.708894565317004,0.181174777066181,-1.38058990699513,-5.05166299004257,-0.411465726140302,"MRPL35","mitochondrial ribosomal protein L35",TRUE
+"222775_s_at",0.767727587789514,0.269960587110992,-1.1314575959128,-5.33467114387843,-0.284976750017034,"MRPL35","mitochondrial ribosomal protein L35",TRUE
+"218890_x_at",0.878278790222455,0.530826646304112,-0.636727051395885,-5.74412371286483,-0.230676671513372,"MRPL35","mitochondrial ribosomal protein L35",TRUE
+"224331_s_at",0.93613089056626,0.714366939311148,0.370719844151746,-5.87296562442091,0.1518359514326,"MRPL36","mitochondrial ribosomal protein L36",TRUE
+"222993_at",0.834454640870101,0.412731872492155,-0.834817185129234,-5.60582339030386,-0.294951461971413,"MRPL37","mitochondrial ribosomal protein L37",TRUE
+"230726_at",0.68680805784522,0.155375013580019,-1.47091277488535,-4.93747977768255,-0.972025196281701,"MRPL38","mitochondrial ribosomal protein L38",TRUE
+"225103_at",0.980459547037842,0.908871150252119,-0.115778339984474,-5.93315669089258,-0.0376847176374717,"MRPL38","mitochondrial ribosomal protein L38",TRUE
+"218558_s_at",0.761006638483723,0.260115322344811,1.155698477171,-5.30927410035359,0.393956779455163,"MRPL39","mitochondrial ribosomal protein L39",TRUE
+"236910_at",0.89085645983207,0.559914751614202,0.591891858418129,-5.7704733403605,0.363966827339831,"MRPL39","mitochondrial ribosomal protein L39",TRUE
+"218105_s_at",0.809707978333974,0.353102283080328,0.948508264872728,-5.51073850279794,0.436068068906962,"MRPL4","mitochondrial ribosomal protein L4",TRUE
+"223742_at",0.848268984089208,0.448047726454691,0.772384685830241,-5.6532160800574,0.313152517102797,"MRPL4","mitochondrial ribosomal protein L4",TRUE
+"223743_s_at",0.863230457544525,0.487303596632014,0.706397297806692,-5.69951977269515,0.311841989570921,"MRPL4","mitochondrial ribosomal protein L4",TRUE
+"203152_at",0.840041055449124,0.42899805086725,-0.805665397094407,-5.62838300751109,-0.276991083390273,"MRPL40","mitochondrial ribosomal protein L40",TRUE
+"227186_s_at",0.227168192678334,0.00285024929451005,-3.35386204058176,-1.57859716844653,-1.25040756303633,"MRPL41","mitochondrial ribosomal protein L41",TRUE
+"225425_s_at",0.420127229072219,0.0174083764454859,-2.57003332636761,-3.15096584759097,-1.19768865570428,"MRPL41","mitochondrial ribosomal protein L41",TRUE
+"225423_x_at",0.973493137611142,0.87229325219416,0.162617947155594,-5.92681149470774,0.109130383129107,"MRPL41","mitochondrial ribosomal protein L41",TRUE
+"230034_x_at",0.980019293742949,0.906152636047207,-0.119249090471441,-5.93275964733373,-0.0520870707230605,"MRPL41","mitochondrial ribosomal protein L41",TRUE
+"221936_x_at",0.998038817582822,0.991079123915684,0.0113077367706341,-5.93962120265723,0.00730190844810963,"MRPL41","mitochondrial ribosomal protein L41",TRUE
+"242289_at",0.610455440146151,0.0831123360968987,-1.8148324525519,-4.45140753090697,-0.953856919367634,"MRPL42","mitochondrial ribosomal protein L42",TRUE
+"217919_s_at",0.803111243433434,0.3408734997447,-0.973377269719799,-5.48845376326133,-0.280622206947703,"MRPL42","mitochondrial ribosomal protein L42",TRUE
+"222466_s_at",0.907576524801672,0.61683122563962,-0.507481724837729,-5.81501888667699,-0.150469456394369,"MRPL42","mitochondrial ribosomal protein L42",TRUE
+"230026_at",0.918041148686074,0.651782557804241,-0.457476944690466,-5.83825929745854,-0.262179569107508,"MRPL43","mitochondrial ribosomal protein L43",TRUE
+"230027_s_at",0.923460171883014,0.671377079695469,-0.429960660753165,-5.85004091066193,-0.199877042082909,"MRPL43","mitochondrial ribosomal protein L43",TRUE
+"224332_s_at",0.984980551359303,0.925927864342295,-0.0940333256062654,-5.93537765633059,-0.0375996545913733,"MRPL43","mitochondrial ribosomal protein L43",TRUE
+"218202_x_at",0.229001275862953,0.00289837920250871,-3.34684207904914,-1.59329804175415,-0.929510098347073,"MRPL44","mitochondrial ribosomal protein L44",TRUE
+"222555_s_at",0.857316604145187,0.472616404104131,-0.730704452508728,-5.68291959288361,-0.219726532607146,"MRPL44","mitochondrial ribosomal protein L44",TRUE
+"224479_s_at",0.948429371744093,0.764892911434627,0.302765350976803,-5.89513429397228,0.150033137247844,"MRPL45","mitochondrial ribosomal protein L45",TRUE
+"237182_at",0.898813992560978,0.588684795165217,-0.54872016391757,-5.79408633696581,-0.50080829406921,"MRPL45P2","mitochondrial ribosomal protein L45 pseudogene 2",TRUE
+"219244_s_at",0.857148066512338,0.471989670236129,-0.731751456346107,-5.6821925688001,-0.260788506178471,"MRPL46","mitochondrial ribosomal protein L46",TRUE
+"223481_s_at",0.892824991541776,0.566252279066627,0.58228679623923,-5.77587660796071,0.18369159955631,"MRPL47","mitochondrial ribosomal protein L47",TRUE
+"223480_s_at",0.92169976703075,0.66581534519701,0.437735766454422,-5.84678453361491,0.121922969175722,"MRPL47","mitochondrial ribosomal protein L47",TRUE
+"218281_at",0.998038817582822,0.9910676650462,-0.0113222622120545,-5.93962104255535,-0.00438213799138687,"MRPL48","mitochondrial ribosomal protein L48",TRUE
+"201717_at",0.81304218438764,0.36242275478547,-0.92994242469913,-5.52703031310827,-0.309543615677974,"MRPL49","mitochondrial ribosomal protein L49",TRUE
+"243219_x_at",0.723973974120865,0.201004571141376,-1.31789036744229,-5.12738844623198,-0.847890178261983,"MRPL50","mitochondrial ribosomal protein L50",TRUE
+"225580_at",0.957571530817866,0.808659183957854,-0.245068156770668,-5.91047351016816,-0.0970067334992759,"MRPL50","mitochondrial ribosomal protein L50",TRUE
+"225581_s_at",0.977874971442423,0.893160938969687,0.135857213487598,-5.93069766421048,0.048689925665018,"MRPL50","mitochondrial ribosomal protein L50",TRUE
+"223086_x_at",0.968066640321622,0.850077138518864,0.19124264797462,-5.92188543927068,0.0579169126962249,"MRPL51","mitochondrial ribosomal protein L51",TRUE
+"224334_s_at",0.984980551359303,0.925944771445185,-0.0940117961243753,-5.93537962737265,-0.0308905893823539,"MRPL51///SPTLC1","mitochondrial ribosomal protein L51///serine palmitoyltransferase long chain base subunit 1",TRUE
+"221997_s_at",0.615668817664405,0.0861708086429892,1.79584210666007,-4.48023360753508,0.677707348627068,"MRPL52","mitochondrial ribosomal protein L52",TRUE
+"226241_s_at",0.97742903818452,0.891833606363259,-0.137556152936923,-5.93047162080836,-0.0428828770067646,"MRPL52","mitochondrial ribosomal protein L52",TRUE
+"225523_at",0.646692716816097,0.117633563153708,-1.62813687277024,-4.72497813387185,-0.654194123862123,"MRPL53///CCDC142","mitochondrial ribosomal protein L53///coiled-coil domain containing 142",TRUE
+"225797_at",0.683019114815084,0.152185379106473,-1.48290364022098,-4.92187905331488,-0.410682819928951,"MRPL54","mitochondrial ribosomal protein L54",TRUE
+"225719_s_at",0.542246001595673,0.0454127927079394,-2.12028144629901,-3.95927147431266,-0.724960574255833,"MRPL55","mitochondrial ribosomal protein L55",TRUE
+"227024_s_at",0.68033297785336,0.1477809366069,1.49980213199824,-4.89972019489366,0.705411803282245,"MRPL55","mitochondrial ribosomal protein L55",TRUE
+"204386_s_at",0.425751189365875,0.0181251774812607,-2.55174911254978,-3.18546701940357,-0.879702384396763,"MRPL57","mitochondrial ribosomal protein L57",TRUE
+"224535_s_at",0.510755470381134,0.0340223397005595,-2.25948938454855,-3.71872091937167,-1.05382078888147,"MRPL57","mitochondrial ribosomal protein L57",TRUE
+"204387_x_at",0.679997635882293,0.147193460856642,-1.50208704238494,-4.89670854060954,-0.479017449234505,"MRPL57","mitochondrial ribosomal protein L57",TRUE
+"221995_s_at",0.971242929121865,0.863190949420307,-0.174327751859015,-5.92489238264801,-0.0637310997313545,"MRPL57","mitochondrial ribosomal protein L57",TRUE
+"204868_at",0.933922051839063,0.707204197145905,-0.380491215236042,-5.86941456543151,-0.172619981074609,"MRPL58","mitochondrial ribosomal protein L58",TRUE
+"211594_s_at",0.82737475618251,0.396171396741804,-0.865254138593558,-5.5814704678875,-0.406968174758244,"MRPL9","mitochondrial ribosomal protein L9",TRUE
+"209609_s_at",0.827446445976113,0.396224923455835,-0.865154458042049,-5.58155154872139,-0.31837766632496,"MRPL9","mitochondrial ribosomal protein L9",TRUE
+"224247_s_at",0.935351255251442,0.712610730196309,0.37311221775456,-5.87210462639162,0.146471492764395,"MRPS10","mitochondrial ribosomal protein S10",TRUE
+"218106_s_at",0.942502815705589,0.742212767385635,0.333069733101292,-5.88579488799505,0.140110989002352,"MRPS10","mitochondrial ribosomal protein S10",TRUE
+"222522_x_at",0.978928101156583,0.897488643042326,0.130320718911138,-5.93141483301208,0.0481823964946635,"MRPS10","mitochondrial ribosomal protein S10",TRUE
+"211595_s_at",0.51470556386048,0.0348342117557822,-2.24825829761937,-3.73847266050918,-0.844846084474687,"MRPS11","mitochondrial ribosomal protein S11",TRUE
+"215919_s_at",0.979272570806007,0.899014310361896,-0.128369913844733,-5.93166043378607,-0.0507102340215857,"MRPS11","mitochondrial ribosomal protein S11",TRUE
+"213840_s_at",0.597346378847428,0.0733067434153681,1.88010124378817,-4.35068250735415,1.03316585499914,"MRPS12","mitochondrial ribosomal protein S12",TRUE
+"204330_s_at",0.90390171502042,0.605442122875548,-0.524057134797689,-5.80679652699792,-0.196488741214618,"MRPS12","mitochondrial ribosomal protein S12",TRUE
+"210008_s_at",0.942502815705589,0.742441167395073,-0.332763010843291,-5.88589383009102,-0.191031437488411,"MRPS12","mitochondrial ribosomal protein S12",TRUE
+"204331_s_at",0.996261754016157,0.981972929044149,-0.02285194561627,-5.93942913402177,-0.00737090536842722,"MRPS12","mitochondrial ribosomal protein S12",TRUE
+"203801_at",0.765442453760984,0.265746937477944,-1.14175135955035,-5.32394434318679,-0.40545457992333,"MRPS14","mitochondrial ribosomal protein S14",TRUE
+"203800_s_at",0.892824991541776,0.566264146898842,-0.582268861578298,-5.77588661699307,-0.196967506304206,"MRPS14","mitochondrial ribosomal protein S14",TRUE
+"221437_s_at",0.711977799428804,0.185651978309473,-1.36597753081169,-5.06957378794208,-0.365186238857577,"MRPS15","mitochondrial ribosomal protein S15",TRUE
+"226296_s_at",0.754491163266461,0.247724136900659,-1.1871930883945,-5.27557272828208,-0.289922321291989,"MRPS15","mitochondrial ribosomal protein S15",TRUE
+"223292_s_at",0.767011398042819,0.268262963458708,1.13559052527493,-5.33037464599105,0.425596626075433,"MRPS15","mitochondrial ribosomal protein S15",TRUE
+"223291_at",0.928473211581075,0.685738554867761,0.410006407114803,-5.85813564285918,0.141673305797441,"MRPS15","mitochondrial ribosomal protein S15",TRUE
+"218046_s_at",0.988303773451367,0.94425425446921,0.0707210072898338,-5.93724774713659,0.0293332438239364,"MRPS16","mitochondrial ribosomal protein S16",TRUE
+"222499_at",0.993615552413264,0.969976579796556,-0.0380652139090187,-5.93897777014974,-0.0153474895229984,"MRPS16","mitochondrial ribosomal protein S16",TRUE
+"218982_s_at",0.957430653957785,0.807267161952455,0.246889188615999,-5.9100384339811,0.0862997963530727,"MRPS17","mitochondrial ribosomal protein S17",TRUE
+"221693_s_at",0.965992617204023,0.841059218693486,0.202907357839875,-5.91965028397907,0.0520507661563734,"MRPS18A","mitochondrial ribosomal protein S18A",TRUE
+"218385_at",0.97928472590149,0.899247128033799,0.128072264974859,-5.93169758174235,0.0429963729576457,"MRPS18A","mitochondrial ribosomal protein S18A",TRUE
+"208907_s_at",0.753827379204375,0.24697649665733,1.18913061076045,-5.27347361323295,0.420565115110119,"MRPS18B","mitochondrial ribosomal protein S18B",TRUE
+"217408_at",0.903919439852106,0.605607615085974,0.523815225524239,-5.80691837914213,0.175904803237234,"MRPS18B","mitochondrial ribosomal protein S18B",TRUE
+"228019_s_at",0.829485424009328,0.400819470817719,-0.856630355755618,-5.58845295050832,-0.26359633080739,"MRPS18C","mitochondrial ribosomal protein S18C",TRUE
+"222948_s_at",0.901202286701133,0.597834603358941,0.535212024799023,-5.80111821761759,0.453968213588131,"MRPS18C","mitochondrial ribosomal protein S18C",TRUE
+"220103_s_at",0.971469873887034,0.864214880220137,-0.173009284421631,-5.92511511064413,-0.0596904660392674,"MRPS18C","mitochondrial ribosomal protein S18C",TRUE
+"218001_at",0.647754107214051,0.119124129916832,-1.62118242226036,-4.73473385306625,-0.622377145052187,"MRPS2","mitochondrial ribosomal protein S2",TRUE
+"222997_s_at",0.99783553534859,0.989633464492413,0.0131402979290677,-5.93959938116022,0.00748268376081462,"MRPS21","mitochondrial ribosomal protein S21",TRUE
+"226257_x_at",0.877636789614313,0.528219365996126,0.640809346461194,-5.74163259138263,0.188223336735179,"MRPS22","mitochondrial ribosomal protein S22",TRUE
+"228059_x_at",0.952687293997936,0.783338088504274,-0.278332523198249,-5.90202147080678,-0.0873843536017667,"MRPS22","mitochondrial ribosomal protein S22",TRUE
+"223448_x_at",0.952914447461733,0.784428446018861,-0.276893765156755,-5.90240911421726,-0.0685859870265322,"MRPS22","mitochondrial ribosomal protein S22",TRUE
+"219220_x_at",0.955396260969248,0.795756321901425,0.261980954119604,-5.90630955894019,0.0764269177110659,"MRPS22","mitochondrial ribosomal protein S22",TRUE
+"238728_at",0.772532966757283,0.283028950290172,-1.10026141753582,-5.36665433921168,-0.575617550626547,"MRPS23","mitochondrial ribosomal protein S23",TRUE
+"223156_at",0.831875452294783,0.407679032153805,-0.844019922641434,-5.59854597936857,-0.360755328781231,"MRPS23","mitochondrial ribosomal protein S23",TRUE
+"224015_s_at",0.590570903980459,0.0683277577631423,-1.91621602623806,-4.29387304154015,-0.814497583412685,"MRPS25","mitochondrial ribosomal protein S25",TRUE
+"224873_s_at",0.904432955312383,0.608219948136879,-0.520000808485755,-5.80883249503414,-0.204108993208522,"MRPS25","mitochondrial ribosomal protein S25",TRUE
+"224869_s_at",0.906162192332284,0.61270983243406,-0.513463037124272,-5.81208151385437,-0.188188100905013,"MRPS25","mitochondrial ribosomal protein S25",TRUE
+"225196_s_at",0.699391325858549,0.17088025259387,-1.41530980123417,-5.00847370095914,-0.633950526375058,"MRPS26","mitochondrial ribosomal protein S26",TRUE
+"227118_s_at",0.760227035076299,0.258201854222743,-1.16048809401683,-5.30420006331157,-0.415710030208841,"MRPS26","mitochondrial ribosomal protein S26",TRUE
+"1563970_at",0.697172073261335,0.167320768694277,1.42770377427885,-4.99284267473911,0.806162660234087,"MRPS27","mitochondrial ribosomal protein S27",TRUE
+"212145_at",0.961212424803935,0.823722456765147,-0.22541519528752,-5.91496508340655,-0.0821253636348729,"MRPS27","mitochondrial ribosomal protein S27",TRUE
+"219819_s_at",0.950905158696228,0.775750776378355,0.288361019942982,-5.89926412579726,0.104678507478711,"MRPS28","mitochondrial ribosomal protein S28",TRUE
+"218398_at",0.675622576285316,0.141997039444796,1.52262957370823,-4.86946765452761,0.57426156542706,"MRPS30","mitochondrial ribosomal protein S30",TRUE
+"222275_at",0.890946678837957,0.560134264289397,0.591558232394288,-5.77066245263555,0.265388672991225,"MRPS30","mitochondrial ribosomal protein S30",TRUE
+"227600_at",0.947969282616012,0.763437546819045,0.304700987088084,-5.89456412467645,0.137055443659683,"MRPS30","mitochondrial ribosomal protein S30",TRUE
+"212604_at",0.622917527985155,0.0937658774366797,1.75108283688564,-4.54729877400858,0.652045179334444,"MRPS31","mitochondrial ribosomal protein S31",TRUE
+"212603_at",0.683019114815084,0.152133245855769,1.48310131580727,-4.92162101117943,0.479373797198097,"MRPS31","mitochondrial ribosomal protein S31",TRUE
+"243821_at",0.843753336849204,0.439218224824095,0.787699932458538,-5.6419108073076,0.400018332098361,"MRPS31","mitochondrial ribosomal protein S31",TRUE
+"218654_s_at",0.597654932724127,0.0750282605898308,-1.86811284446879,-4.36937274929686,-0.502461991388705,"MRPS33","mitochondrial ribosomal protein S33",TRUE
+"218112_at",0.756275866957977,0.251194987391577,-1.17825513822536,-5.28521744934129,-0.418094731440263,"MRPS34","mitochondrial ribosomal protein S34",TRUE
+"217942_at",0.957610494018084,0.80986747002644,0.243488173449766,-5.91084840105388,0.0752824731795467,"MRPS35","mitochondrial ribosomal protein S35",TRUE
+"224302_s_at",0.971867994936839,0.865270874415757,0.171649859154368,-5.92534299217802,0.0557571854725705,"MRPS36","mitochondrial ribosomal protein S36",TRUE
+"236779_at",0.726636642789909,0.206225212669265,1.30219322536487,-5.14588285078489,0.564423608390043,"MRPS5","mitochondrial ribosomal protein S5",TRUE
+"237560_at",0.819018525257656,0.374839848791161,0.905697884365603,-5.54785881619112,0.558389555068227,"MRPS5","mitochondrial ribosomal protein S5",TRUE
+"224333_s_at",0.869850840015332,0.507664861698279,-0.673387333689117,-5.72120542647186,-0.185924063636213,"MRPS5","mitochondrial ribosomal protein S5",TRUE
+"224877_s_at",0.904832003218088,0.609609012121515,0.517975737057599,-5.80984315933525,0.149952965092798,"MRPS5","mitochondrial ribosomal protein S5",TRUE
+"224919_at",0.994701128358967,0.975458522024065,-0.0311123234562303,-5.93921202599941,-0.011325420036771,"MRPS6","mitochondrial ribosomal protein S6",TRUE
+"217932_at",0.725127644983527,0.203170721896035,-1.31133924415214,-5.13512977670834,-0.49245967495769,"MRPS7","mitochondrial ribosomal protein S7",TRUE
+"226749_at",0.615964925929095,0.0870907498808358,-1.79024401076948,-4.48868915135514,-0.561924353206146,"MRPS9","mitochondrial ribosomal protein S9",TRUE
+"225126_at",0.837368340567858,0.421174649263818,-0.819598077067249,-5.61769468633939,-0.272473918205455,"MRRF","mitochondrial ribosome recycling factor",TRUE
+"224101_x_at",0.673870607802125,0.140411745631718,1.52901922763456,-4.86093438071471,1.54850692701537,"MRS2","MRS2, magnesium transporter",TRUE
+"218536_at",0.789795896476304,0.318495453478404,1.02052164065951,-5.44476910553481,0.363363985399252,"MRS2","MRS2, magnesium transporter",TRUE
+"218538_s_at",0.9181984176728,0.652764522731225,0.456089595456348,-5.83887046860724,0.134821419553385,"MRS2","MRS2, magnesium transporter",TRUE
+"228542_at",0.936992192746977,0.718801259849126,-0.364689005025775,-5.87511182114209,-0.1851205880556,"MRS2","MRS2, magnesium transporter",TRUE
+"220688_s_at",0.906507435035949,0.614427594639651,0.510967782255794,-5.81331099293164,0.214817553820573,"MRTO4","MRT4 homolog, ribosome maturation factor",TRUE
+"235783_at",0.969946179106301,0.857906903500426,0.181136853726457,-5.92371529062554,0.088613701548578,"MRTO4","MRT4 homolog, ribosome maturation factor",TRUE
+"226047_at",0.515455272393069,0.0360135188027713,2.23236230786601,-3.76632760686294,0.848277418515724,"MRVI1","murine retrovirus integration site 1 homolog",TRUE
+"230214_at",0.597346378847428,0.0734429671664213,1.87914369166946,-4.35217845190459,0.667035508479606,"MRVI1","murine retrovirus integration site 1 homolog",TRUE
+"224550_s_at",0.994098505325585,0.972758238265405,-0.034536945569769,-5.9391025282501,-0.0265988707534746,"MRVI1","murine retrovirus integration site 1 homolog",TRUE
+"231595_at",0.877740599174557,0.528554759711442,0.640283597576647,-5.74195427541583,0.356052077350811,"MRVI1-AS1","MRVI1 antisense RNA 1",TRUE
+"217418_x_at",0.189644672791897,0.00191645117755007,-3.51945036790617,-1.22967814473716,-1.2959026146969,"MS4A1","membrane spanning 4-domains A1",TRUE
+"210356_x_at",0.7768734672127,0.294870413452335,1.07288297925451,-5.39406777657926,0.617747006089476,"MS4A1","membrane spanning 4-domains A1",TRUE
+"228599_at",0.82706053436911,0.395573310113572,0.866368521955646,-5.58056342950437,0.815508995073817,"MS4A1","membrane spanning 4-domains A1",TRUE
+"228592_at",0.941158863404109,0.736270520930444,-0.341061238152367,-5.88318521987657,-0.230480602407016,"MS4A1","membrane spanning 4-domains A1",TRUE
+"220834_at",0.327864702134751,0.00767820520882201,2.93208321830282,-2.44471271836336,1.81545076008945,"MS4A12","membrane spanning 4-domains A12",TRUE
+"229510_at",0.969946179106301,0.857812470488519,0.181258620311045,-5.92369383163187,0.0779123706418261,"MS4A14","membrane spanning 4-domains A14",TRUE
+"1564194_a_at",0.956084625435459,0.801426236159799,0.254539629111452,-5.90817563213851,0.118836963362861,"MS4A15","membrane spanning 4-domains A15",TRUE
+"207497_s_at",0.849646596450765,0.451089788750496,0.767150656273709,-5.6570316621163,0.424873953905878,"MS4A2","membrane spanning 4-domains A2",TRUE
+"207496_at",0.937113154905832,0.720193350099825,-0.362798560198422,-5.87577742063458,-0.23458476549356,"MS4A2","membrane spanning 4-domains A2",TRUE
+"1554892_a_at",0.72050514215489,0.196574632885378,-1.3314613057039,-5.11124848614657,-0.601690660752236,"MS4A3","membrane spanning 4-domains A3",TRUE
+"210254_at",0.997293485734839,0.986273444025648,0.017399749593304,-5.93953602283588,0.0139979571692708,"MS4A3","membrane spanning 4-domains A3",TRUE
+"219607_s_at",0.56861088242915,0.058538769000126,1.99454624162333,-4.16810960779746,1.83280484018682,"MS4A4A","membrane spanning 4-domains A4A",TRUE
+"1555728_a_at",0.771556896910173,0.280907390761663,-1.10525360997736,-5.36158950761896,-0.659061047512242,"MS4A4A","membrane spanning 4-domains A4A",TRUE
+"224357_s_at",0.955730092376044,0.797626231392883,-0.259525192318212,-5.90693130020419,-0.0873721590057057,"MS4A4A","membrane spanning 4-domains A4A",TRUE
+"220790_s_at",0.993474831312851,0.969330157848002,0.0388852077043021,-5.93894703921038,0.0194493630793202,"MS4A5","membrane spanning 4-domains A5",TRUE
+"230550_at",0.740610299769501,0.230199782169573,1.23381559637163,-5.22423831237832,0.961607581920398,"MS4A6A","membrane spanning 4-domains A6A",TRUE
+"224356_x_at",0.872809248863504,0.51710855049722,0.658330620116781,-5.73076705609725,0.311221926667486,"MS4A6A","membrane spanning 4-domains A6A",TRUE
+"223922_x_at",0.908641534736832,0.619870518594405,0.503082844925177,-5.81715771421042,0.270646435326131,"MS4A6A","membrane spanning 4-domains A6A",TRUE
+"219666_at",0.93929971411701,0.728283682608677,-0.351838333642172,-5.87956903546737,-0.211602262449128,"MS4A6A","membrane spanning 4-domains A6A",TRUE
+"232725_s_at",0.955892698633978,0.799900344460188,0.256540782419503,-5.90767905147254,0.17345894947011,"MS4A6A","membrane spanning 4-domains A6A",TRUE
+"232724_at",0.95599181039166,0.801197973840749,0.254838919356612,-5.90810160985018,0.193384824217072,"MS4A6A","membrane spanning 4-domains A6A",TRUE
+"223280_x_at",0.990810941805126,0.956653218240628,-0.0549723016284939,-5.93821170558362,-0.027908127442962,"MS4A6A","membrane spanning 4-domains A6A",TRUE
+"231335_at",0.98529096111871,0.92703175716055,-0.0926277250685384,-5.93550539387541,-0.0692233116673311,"MS4A6E","membrane spanning 4-domains A6E",TRUE
+"223344_s_at",0.705559553212919,0.177232079430195,-1.39369691578113,-5.03546288729098,-0.798161934231943,"MS4A7","membrane spanning 4-domains A7",TRUE
+"224358_s_at",0.760439386481756,0.259374229527098,-1.15755040762321,-5.3073143813794,-0.919862440598901,"MS4A7","membrane spanning 4-domains A7",TRUE
+"223343_at",0.992451894371035,0.96477137973185,-0.0446688800000985,-5.93871168610799,-0.038078223206754,"MS4A7","membrane spanning 4-domains A7",TRUE
+"224355_s_at",0.962808206628386,0.830959490129072,-0.216005753538011,-5.91698337054552,-0.171705182052198,"MS4A8","membrane spanning 4-domains A8",TRUE
+"237434_x_at",0.812302873476553,0.356800014489319,-0.941103587988795,-5.51727165733184,-0.472336114548567,"MSANTD1","Myb/SANT DNA binding domain containing 1",TRUE
+"221208_s_at",0.756952614607938,0.252447769910092,-1.17505167433366,-5.28865873040394,-0.571102221116581,"MSANTD2","Myb/SANT DNA binding domain containing 2",TRUE
+"1552277_a_at",0.62986301194198,0.101166265622514,1.71036640905956,-4.60721806657578,0.932516242891255,"MSANTD3","Myb/SANT DNA binding domain containing 3",TRUE
+"1555841_at",0.92051722798026,0.662060306548925,0.443000695146733,-5.84454694183879,0.236016267576519,"MSANTD3","Myb/SANT DNA binding domain containing 3",TRUE
+"205122_at",0.554642754132296,0.0511479240603922,2.06180604280835,-4.05743218372593,1.68881145075721,"MSANTD3-TMEFF1///TMEFF1","MSANTD3-TMEFF1 readthrough///transmembrane protein with EGF like and two follistatin like domains 1",TRUE
+"205123_s_at",0.571736836402345,0.0597116736017113,1.98457505635707,-4.18430881970842,1.86232280942257,"MSANTD3-TMEFF1///TMEFF1","MSANTD3-TMEFF1 readthrough///transmembrane protein with EGF like and two follistatin like domains 1",TRUE
+"223799_at",0.797856706388872,0.331779973963556,0.992268689376194,-5.47117404039595,0.786486558376188,"MSANTD4","Myb/SANT DNA binding domain containing 4 with coiled-coils",TRUE
+"227418_at",0.862800800218883,0.486607957626007,0.707538890990758,-5.69875210442125,0.796994211863082,"MSANTD4","Myb/SANT DNA binding domain containing 4 with coiled-coils",TRUE
+"240627_x_at",0.993892931327222,0.97128551903664,-0.0364048904981536,-5.93903798878025,-0.03518766576682,"MSANTD4","Myb/SANT DNA binding domain containing 4 with coiled-coils",TRUE
+"209928_s_at",0.552420073963858,0.0501353861655159,2.07168751800481,-4.04096908725742,1.44943784908137,"MSC","musculin",TRUE
+"228438_at",0.580630437263151,0.0629234871528797,1.95813253135515,-4.22700127096686,2.27847060077195,"MSC-AS1","MSC antisense RNA 1",TRUE
+"209421_at",0.672434875127089,0.138381144419977,1.53729092598499,-4.84984551216148,0.528426828474972,"MSH2","mutS homolog 2",TRUE
+"210947_s_at",0.911537707450982,0.629865470278886,-0.488686857623415,-5.82403023077901,-0.139426196151737,"MSH3","mutS homolog 3",TRUE
+"229662_at",0.976371465776674,0.88717766852984,0.14351890486645,-5.92965608908785,0.0803600590713365,"MSH3","mutS homolog 3",TRUE
+"205887_x_at",0.9802233499944,0.907096624907518,-0.118043723940193,-5.93289886501119,-0.0290160786433749,"MSH3","mutS homolog 3",TRUE
+"210533_at",0.897949253801113,0.586658668406364,0.551725322297539,-5.79249879861846,0.386504905051661,"MSH4","mutS homolog 4",TRUE
+"221406_s_at",0.290430545694223,0.00505697081848926,3.11157149223301,-2.08081472544504,1.53230937191548,"MSH5-SAPCD1///SAPCD1","MSH5-SAPCD1 readthrough (NMD candidate)///suppressor APC domain containing 1",TRUE
+"212913_at",0.700890836612645,0.172591070800189,1.40942623721439,-5.01585472469801,0.724614148677825,"MSH5-SAPCD1///SAPCD1","MSH5-SAPCD1 readthrough (NMD candidate)///suppressor APC domain containing 1",TRUE
+"210410_s_at",0.7717895132349,0.281799562623102,1.1031509421739,-5.36372525356386,0.697824293140351,"MSH5-SAPCD1///SAPCD1///MSH5","MSH5-SAPCD1 readthrough (NMD candidate)///suppressor APC domain containing 1///mutS homolog 5",TRUE
+"211449_at",0.738061563377262,0.224866659550482,1.24853655675583,-5.2076750820982,0.761574488758803,"MSH6","mutS homolog 6",TRUE
+"202911_at",0.820291269575398,0.379001860418745,0.89769074395626,-5.55462617467882,0.25395010188217,"MSH6","mutS homolog 6",TRUE
+"211450_s_at",0.838303520227789,0.423171966979065,0.816025790688013,-5.62045151452055,0.272169941635402,"MSH6","mutS homolog 6",TRUE
+"206333_at",0.68272466434042,0.150617739392302,-1.48887195784439,-4.91407591219335,-0.987263132573502,"MSI1","musashi RNA binding protein 1",TRUE
+"225233_at",0.585036027492332,0.0655395467100361,-1.93746182225931,-4.26010275595796,-1.49704101264583,"MSI2","musashi RNA binding protein 2",TRUE
+"1559987_at",0.707596006786505,0.179027344235032,1.38770034720401,-5.04289030909753,0.627594254225759,"MSI2","musashi RNA binding protein 2",TRUE
+"243010_at",0.722442821599878,0.199111518239627,-1.32366078091133,-5.1205427015348,-0.916057463345429,"MSI2","musashi RNA binding protein 2",TRUE
+"1552364_s_at",0.774230543658252,0.287558222357942,-1.0896936275055,-5.37730859578897,-0.775833258214084,"MSI2","musashi RNA binding protein 2",TRUE
+"226134_s_at",0.807084045192774,0.348412780943957,-0.957974760334117,-5.50231789606278,-1.04196391027408,"MSI2","musashi RNA binding protein 2",TRUE
+"225237_s_at",0.813065886130395,0.362735890350057,-0.929324273316006,-5.52756766029079,-0.894485236413711,"MSI2","musashi RNA binding protein 2",TRUE
+"243579_at",0.826134344333512,0.393799067416668,-0.869680793502247,-5.57786104040888,-0.571948346734754,"MSI2","musashi RNA binding protein 2",TRUE
+"239232_at",0.831392326632573,0.405678079231423,0.84768431748649,-5.59562749060651,0.323512002943521,"MSI2","musashi RNA binding protein 2",TRUE
+"225240_s_at",0.844735153180923,0.441662018030325,-0.783442355147624,-5.64507462474154,-0.911625950759761,"MSI2","musashi RNA binding protein 2",TRUE
+"225238_at",0.921079309141156,0.664014730498405,-0.440258825008208,-5.84571551148096,-0.30466673063558,"MSI2","musashi RNA binding protein 2",TRUE
+"230155_x_at",0.684160057382581,0.153058541287577,1.47960099650976,-4.92618616184387,0.910485103946686,"MSL1","male specific lethal 1 homolog",TRUE
+"224765_at",0.844608293507187,0.441491021169396,-0.78373979560841,-5.64485412080387,-0.226781619116524,"MSL1","male specific lethal 1 homolog",TRUE
+"212708_at",0.885029460971826,0.545825864103479,-0.613449544297916,-5.75803535214761,-0.321980185411576,"MSL1","male specific lethal 1 homolog",TRUE
+"218733_at",0.8920930097751,0.562758698766001,-0.587574716934583,-5.77291249996134,-0.156290185084149,"MSL2","male-specific lethal 2 homolog (Drosophila)",TRUE
+"214009_at",0.778665768282906,0.299081907736286,-1.06333604399828,-5.40348174579114,-0.355942702098908,"MSL3","male-specific lethal 3 homolog (Drosophila)",TRUE
+"236165_at",0.897011777275924,0.582554214518544,0.557828880433834,-5.78924855590692,0.211554696722388,"MSL3","male-specific lethal 3 homolog (Drosophila)",TRUE
+"207551_s_at",0.905942431650814,0.61242868251021,-0.513871755200564,-5.81187957093422,-0.219916265173993,"MSL3","male-specific lethal 3 homolog (Drosophila)",TRUE
+"204885_s_at",0.0256047637435791,2.2010496496538e-05,5.35278745372177,2.69458060366509,5.62759350028223,"MSLN","mesothelin",TRUE
+"207430_s_at",0.425744368467229,0.0180949815074292,-2.55250559140685,-3.18404205748679,-3.33668096750092,"MSMB","microseminoprotein beta",TRUE
+"210297_s_at",0.517348414110187,0.036562126604879,-2.22512858995895,-3.77896401945246,-2.16523136373668,"MSMB","microseminoprotein beta",TRUE
+"209146_at",0.743110021089368,0.233255677767457,-1.22549697490451,-5.23352307790047,-0.518541159710102,"MSMO1","methylsterol monooxygenase 1",TRUE
+"200600_at",0.55848332432723,0.0527379863466207,2.04663597801514,-4.08260625939311,4.76972138560034,"MSN","moesin",TRUE
+"233749_at",0.769847953580141,0.278448953062519,1.1110728444302,-5.3556599084028,0.615423395673183,"MSN","moesin",TRUE
+"214770_at",0.661974206478491,0.129754150043958,1.57359046330798,-4.80062492178165,1.74744223745775,"MSR1","macrophage scavenger receptor 1",TRUE
+"208423_s_at",0.697172073261335,0.167268521943604,1.42788726370642,-4.99261042231047,0.923548163034081,"MSR1","macrophage scavenger receptor 1",TRUE
+"208422_at",0.819018525257656,0.375256450360615,0.904893767074101,-5.54854093646781,0.630343308425658,"MSR1","macrophage scavenger receptor 1",TRUE
+"211887_x_at",0.923050713409153,0.670211774133905,0.431587470770057,-5.84936430994466,0.29844204222111,"MSR1","macrophage scavenger receptor 1",TRUE
+"219281_at",0.834454640870101,0.412862231149846,0.834580711452062,-5.60600940831874,0.669211038685813,"MSRA","methionine sulfoxide reductase A",TRUE
+"240031_at",0.939166148226364,0.727526062106531,0.352862822807961,-5.87921948843082,0.117116390509198,"MSRA","methionine sulfoxide reductase A",TRUE
+"217977_at",0.771855357662161,0.281892659386832,-1.10293181031404,-5.36394762481729,-0.435952379297348,"MSRB1","methionine sulfoxide reductase B1",TRUE
+"218773_s_at",0.305949355810268,0.00609592906254152,-3.0316227166874,-2.24386742561146,-1.29799630381069,"MSRB2","methionine sulfoxide reductase B2",TRUE
+"219451_at",0.731548533938014,0.21517259147488,-1.27599298993639,-5.17633275423616,-0.946673135075018,"MSRB2","methionine sulfoxide reductase B2",TRUE
+"230575_at",0.876572652459579,0.525233405967309,-0.645498056250557,-5.73875254380299,-0.286519709422197,"MSRB2","methionine sulfoxide reductase B2",TRUE
+"225790_at",0.71242055183987,0.18648783613682,-1.36328046338744,-5.07286230975261,-1.79630275456868,"MSRB3","methionine sulfoxide reductase B3",TRUE
+"1554126_at",0.774011928861764,0.285611601401478,-1.09422067785838,-5.372755710348,-0.683457939216829,"MSRB3","methionine sulfoxide reductase B3",TRUE
+"238583_at",0.908709061737317,0.620530026681005,-0.502129644458473,-5.8176187850594,-0.322551581099984,"MSRB3","methionine sulfoxide reductase B3",TRUE
+"225782_at",0.90998880119877,0.625431613313133,-0.495059957588322,-5.82101180489554,-1.02313506734545,"MSRB3","methionine sulfoxide reductase B3",TRUE
+"1554127_s_at",0.986889306520757,0.938921318453981,-0.0775001078219795,-5.93675847305566,-0.0866391321522899,"MSRB3","methionine sulfoxide reductase B3",TRUE
+"241793_at",0.712948021516228,0.187040834141283,-1.36150134390786,-5.07502861497675,-0.976026932763773,"MSS51","MSS51 mitochondrial translational activator",TRUE
+"216320_x_at",0.697713925841949,0.168582343410217,1.4232870505013,-4.99842577831709,1.03881245919135,"MST1","macrophage stimulating 1",TRUE
+"205614_x_at",0.785440072877511,0.310947940513136,1.03694184005424,-5.42911514504835,0.623521547483449,"MST1","macrophage stimulating 1",TRUE
+"213382_at",0.76912869907427,0.274572985807988,1.12032383843441,-5.34617665459271,0.594017375622561,"MST1L","macrophage stimulating 1 like",TRUE
+"215563_s_at",0.925504446660705,0.677113025530338,0.421970129034465,-5.85332777154061,0.314346063447502,"MST1L","macrophage stimulating 1 like",TRUE
+"205455_at",0.64513208805899,0.115950977174181,1.63607657375123,-4.71380100897998,1.13170866897395,"MST1R","macrophage stimulating 1 receptor",TRUE
+"207145_at",0.993083193605528,0.96717726915768,-0.0416163724513329,-5.9388399603827,-0.0390429736515472,"MSTN","myostatin",TRUE
+"224233_s_at",0.612881122757103,0.0844862372605448,-1.80622830294288,-4.46449524124502,-0.585519782612304,"MSTO1","misato 1, mitochondrial distribution and morphology regulator",TRUE
+"222584_at",0.986145735582101,0.932081144622901,-0.0862006691525096,-5.93606497913933,-0.0300564814421662,"MSTO1","misato 1, mitochondrial distribution and morphology regulator",TRUE
+"218296_x_at",0.756683026227849,0.252103118532538,-1.17593179165308,-5.28771409117004,-0.307685196001142,"MSTO2P///MSTO1","misato family member 2, pseudogene///misato 1, mitochondrial distribution and morphology regulator",TRUE
+"205932_s_at",0.906845308365483,0.615054271944429,-0.510058276941969,-5.81375767830884,-0.744764175166239,"MSX1","msh homeobox 1",TRUE
+"228473_at",0.933400538871064,0.705238197417392,-0.383179791050928,-5.86842151507337,-0.163700614425233,"MSX1","msh homeobox 1",TRUE
+"210319_x_at",0.0592928515268338,0.000120688072837326,-4.65219616801445,1.20683185085447,-4.65414790553007,"MSX2","msh homeobox 2",TRUE
+"205555_s_at",0.0723378272955723,0.000223421791943352,-4.40079348715972,0.665017004747363,-4.73619659455761,"MSX2","msh homeobox 2",TRUE
+"205556_at",0.760237493549547,0.258371240458878,-1.16006304365604,-5.30465109883765,-0.553375292569051,"MSX2","msh homeobox 2",TRUE
+"212859_x_at",0.635368778245437,0.106459375977912,1.68277333088721,-4.64722403807404,2.06118438307497,"MT1E","metallothionein 1E",TRUE
+"216336_x_at",0.647754107214051,0.118884293253629,1.62229647424749,-4.73317322504755,1.47684950986882,"MT1E","metallothionein 1E",TRUE
+"217165_x_at",0.818637718131529,0.372157762524947,0.910889002686554,-5.54344180953933,0.565837501209977,"MT1F","metallothionein 1F",TRUE
+"213629_x_at",0.884749233889577,0.544230704121657,0.615908709289974,-5.75658922958787,0.28838542623431,"MT1F","metallothionein 1F",TRUE
+"210472_at",0.631255973326775,0.102238116851795,1.70468140456956,-4.61550049719502,0.969814489612937,"MT1G","metallothionein 1G",TRUE
+"204745_x_at",0.774880457498598,0.291371375950441,1.08088939414993,-5.38611488133533,0.634472537030499,"MT1G","metallothionein 1G",TRUE
+"206461_x_at",0.709893941953691,0.182657301790664,1.37571998767115,-5.05764978902668,0.976073814528561,"MT1H","metallothionein 1H",TRUE
+"211456_x_at",0.645072069975909,0.115521330443255,1.63811946286446,-4.71091837073867,1.19252647418995,"MT1HL1","metallothionein 1H-like 1",TRUE
+"217546_at",0.327864702134751,0.00762616938107026,2.93503008425929,-2.43880331937517,3.68397945554491,"MT1M","metallothionein 1M",TRUE
+"204326_x_at",0.755940660414394,0.250645261122033,1.17966459283483,-5.2837007675117,0.776092610689963,"MT1X","metallothionein 1X",TRUE
+"208581_x_at",0.760237493549547,0.258309001204331,1.16021920009922,-5.30448541271976,0.826364094328273,"MT1X","metallothionein 1X",TRUE
+"212185_x_at",0.76772687203753,0.269599111565625,1.13233602107848,-5.33375911046741,0.677631739890034,"MT2A","metallothionein 2A",TRUE
+"205970_at",0.990810941805126,0.953471666892549,0.0590118689390972,-5.93798747410723,0.0173635528971223,"MT3","metallothionein 3",TRUE
+"217395_at",0.879419229950485,0.533664489058363,0.632296098879148,-5.74681026574427,0.360487646736417,"MT4","metallothionein 4",TRUE
+"211783_s_at",0.800179799309599,0.335863305246566,-0.983742247586415,-5.4790105026942,-0.451357672961853,"MTA1","metastasis associated 1",TRUE
+"202247_s_at",0.952697366942815,0.783528854718998,-0.278080758476167,-5.90208944751231,-0.0999752783430754,"MTA1","metastasis associated 1",TRUE
+"203444_s_at",0.88020017258149,0.535464331328487,-0.629492455875749,-5.74850083249857,-0.535909045719215,"MTA2","metastasis associated 1 family member 2",TRUE
+"226852_at",0.812302873476553,0.360107676927303,0.93452368762589,-5.52303767156653,0.716228477797339,"MTA3","metastasis associated 1 family member 3",TRUE
+"223311_s_at",0.900243513823496,0.595008685121896,-0.539373154032123,-5.79897023364839,-0.195540565138531,"MTA3","metastasis associated 1 family member 3",TRUE
+"211364_at",0.399719600134805,0.0142341849375851,2.66057099003168,-2.97834655095681,0.691014001131093,"MTAP","methylthioadenosine phosphorylase",TRUE
+"211363_s_at",0.62110896023334,0.0911896541673824,1.76590390501328,-4.5252290302194,1.41262492347514,"MTAP","methylthioadenosine phosphorylase",TRUE
+"231984_at",0.726480797733202,0.205514010032729,1.30431332078517,-5.14339590531147,1.97033702989876,"MTAP","methylthioadenosine phosphorylase",TRUE
+"204956_at",0.734385519974716,0.218712166987045,1.26585993240475,-5.18796786143781,1.64353918908821,"MTAP","methylthioadenosine phosphorylase",TRUE
+"217134_at",0.766989207029679,0.268120067927906,-1.13593928474507,-5.33001145132301,-0.647183752042101,"MTAP","methylthioadenosine phosphorylase",TRUE
+"216685_s_at",0.77204612088057,0.282239385961648,1.10211614394002,-5.36477500408195,1.30623413163744,"MTAP","methylthioadenosine phosphorylase",TRUE
+"233211_at",0.854184492233394,0.464630211807439,0.744107898790428,-5.67353783080215,0.396377525312438,"MTBP","MDM2 binding protein",TRUE
+"233436_at",0.871744769522775,0.513679007917833,0.663780721519259,-5.72732994125788,0.456302576147412,"MTBP","MDM2 binding protein",TRUE
+"1563614_at",0.907189812622248,0.615992234348507,0.508697812922797,-5.81442439435477,0.412551209366986,"MTBP","MDM2 binding protein",TRUE
+"1552518_s_at",0.948015976270656,0.76391691421969,0.304063297190162,-5.89475236314636,0.153811853085721,"MTBP","MDM2 binding protein",TRUE
+"221619_s_at",0.955645941042265,0.797003420830045,0.260342950776285,-5.90672490899313,0.0686737709518734,"MTCH1","mitochondrial carrier 1",TRUE
+"217772_s_at",0.503118098141456,0.0326026048781926,-2.2797312154828,-3.6829749327945,-0.734658142485634,"MTCH2","mitochondrial carrier 2",TRUE
+"222403_at",0.885029460971826,0.545640796366019,-0.613734656715533,-5.75786797645051,-0.223668988918387,"MTCH2","mitochondrial carrier 2",TRUE
+"213358_at",0.498206796273596,0.031073595916607,2.30245362573031,-3.64262534403149,1.90226293013677,"MTCL1","microtubule crosslinking factor 1",TRUE
+"244790_at",0.942502815705589,0.741982841632266,-0.333378537223385,-5.88569518322704,-0.16594986302422,"MTCP1","mature T-cell proliferation 1",TRUE
+"212248_at",0.399841271548557,0.0142531438179815,-2.65997591992691,-2.97949050119187,-0.998018810695205,"MTDH","metadherin",TRUE
+"1559822_s_at",0.435020772526436,0.0197957326391545,-2.51163077569373,-3.26072721173819,-0.872441684266567,"MTDH","metadherin",TRUE
+"212250_at",0.615821255316333,0.0867252822030373,-1.79246184651006,-4.48534155699044,-0.657279231804837,"MTDH","metadherin",TRUE
+"227277_at",0.778665768282906,0.299120121348341,-1.06324985933637,-5.40356638690931,-0.484828125838396,"MTDH","metadherin",TRUE
+"212251_at",0.83030603167465,0.402386382713079,-0.853737687749273,-5.59078049031022,-0.32076104945908,"MTDH","metadherin",TRUE
+"204871_at",0.894729774938685,0.571988839934739,0.573640000527923,-5.78066761858841,0.199429304930423,"MTERF1","mitochondrial transcription termination factor 1",TRUE
+"225346_at",0.565043084457947,0.0564267991063629,-2.01295651834604,-4.13805733650501,-0.911710330849351,"MTERF2","mitochondrial transcription termination factor 2",TRUE
+"225341_at",0.5932897315606,0.0699053778775712,-1.90453000061499,-4.31233797220423,-0.923107666378181,"MTERF2","mitochondrial transcription termination factor 2",TRUE
+"219363_s_at",0.714791050845163,0.190269857249377,-1.35119488251153,-5.08753155307955,-0.502952289221032,"MTERF3","mitochondrial transcription termination factor 3",TRUE
+"1557966_x_at",0.633326968581968,0.104531739447078,-1.69268443661556,-4.63291075765779,-0.603703008864692,"MTERF4","mitochondrial transcription termination factor 4",TRUE
+"1557965_at",0.645740804644555,0.116873831515001,-1.63170997528662,-4.71995326972178,-0.720931781297407,"MTERF4","mitochondrial transcription termination factor 4",TRUE
+"214364_at",0.760374043437572,0.259090847575787,-1.15825959106098,-5.30656319177141,-0.46923160806396,"MTERF4","mitochondrial transcription termination factor 4",TRUE
+"226486_at",0.969836236909017,0.8556199492189,-0.184086558119408,-5.92319141913118,-0.0656894927112965,"MTERF4","mitochondrial transcription termination factor 4",TRUE
+"227150_at",0.836756831475262,0.418636863775614,-0.824152376553903,-5.61416365294868,-0.252704305233939,"MTF1","metal regulatory transcription factor 1",TRUE
+"205322_s_at",0.929972194057784,0.691062464972541,-0.402652451247493,-5.86102346388051,-0.0955317494730572,"MTF1","metal regulatory transcription factor 1",TRUE
+"205323_s_at",0.986421906591669,0.936082176120323,0.0811106553822925,-5.93647963035658,0.0202829668460094,"MTF1","metal regulatory transcription factor 1",TRUE
+"209704_at",0.769258076576208,0.275774698487534,-1.11744551811934,-5.34913470404782,-0.468434082414076,"MTF2","metal response element binding transcription factor 2",TRUE
+"203347_s_at",0.812302873476553,0.360086584890643,-0.934565516904609,-5.52300113363118,-0.394167782493168,"MTF2","metal response element binding transcription factor 2",TRUE
+"209705_at",0.854938566647589,0.46705368170456,-0.74002620540187,-5.67641194771383,-0.251573411734134,"MTF2","metal response element binding transcription factor 2",TRUE
+"203345_s_at",0.896690757315733,0.58166321731501,-0.559156670590409,-5.78853689042876,-0.186633897930443,"MTF2","metal response element binding transcription factor 2",TRUE
+"203346_s_at",0.957571530817866,0.808842587688633,-0.24482829278121,-5.9105305791662,-0.078473446900551,"MTF2","metal response element binding transcription factor 2",TRUE
+"235689_at",0.629618998226163,0.100545640560488,-1.71368162312971,-4.6023786285088,-0.618109401934447,"MTFMT","mitochondrial methionyl-tRNA formyltransferase",TRUE
+"223172_s_at",0.962351204352784,0.828386215195525,0.219349143141049,-5.91627603618583,0.102175978102734,"MTFP1","mitochondrial fission process 1",TRUE
+"203208_s_at",0.627592083375654,0.0991176523081622,-1.72137625715632,-4.59111926772704,-0.709183617635972,"MTFR1","mitochondrial fission regulator 1",TRUE
+"203207_s_at",0.654991908675739,0.123811022247129,-1.59977943258891,-4.76455519452061,-0.715739012829415,"MTFR1","mitochondrial fission regulator 1",TRUE
+"232314_at",0.990810941805126,0.956700923069983,0.0549117388375518,-5.93821494646081,0.0426183615160824,"MTFR1","mitochondrial fission regulator 1",TRUE
+"224280_s_at",0.698391916012681,0.16954482775673,-1.41993522336617,-5.00265329493999,-0.538275458062124,"MTFR1L","mitochondrial fission regulator 1 like",TRUE
+"234944_s_at",0.587947964200177,0.0669102309042596,1.92692008669014,-4.276891025595,0.663153788176116,"MTFR2","mitochondrial fission regulator 2",TRUE
+"228069_at",0.60446202979082,0.0786491610412784,1.84366064955669,-4.40723163761004,0.748607731422023,"MTFR2","mitochondrial fission regulator 2",TRUE
+"234945_at",0.634202341398092,0.105325653540096,1.68858384629351,-4.63884038411481,1.53516963758661,"MTFR2","mitochondrial fission regulator 2",TRUE
+"212767_at",0.977415153466377,0.891790175517693,0.13761174988247,-5.93046417626815,0.0685316314028395,"MTG1","mitochondrial ribosome associated GTPase 1",TRUE
+"226854_at",0.673622120503302,0.139997588573919,-1.53069828150211,-4.85868731895702,-0.532956396554839,"MTG2","mitochondrial ribosome associated GTPase 2",TRUE
+"236890_at",0.85334340854827,0.461204927720706,0.749898542974934,-5.66943465763619,0.300992586349089,"MTG2","mitochondrial ribosome associated GTPase 2",TRUE
+"226598_s_at",0.888773817669969,0.555657724354119,-0.598375380158182,-5.76677776846326,-0.265771027259723,"MTG2","mitochondrial ribosome associated GTPase 2",TRUE
+"226606_s_at",0.909098669732994,0.623004225874194,0.498557823061037,-5.81933891270669,0.173702038559927,"MTG2","mitochondrial ribosome associated GTPase 2",TRUE
+"1568822_at",0.925511384407886,0.678230083600512,-0.420417257853358,-5.8539595035862,-0.343802430191432,"MTG2","mitochondrial ribosome associated GTPase 2",TRUE
+"202309_at",0.794426378358553,0.326281878361071,-1.00386465924763,-5.46041786938703,-0.310785984794679,"MTHFD1","methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1",TRUE
+"239846_at",0.920491425364243,0.661566542297399,-0.443693944679995,-5.84425035522845,-0.321792759294699,"MTHFD1","methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1",TRUE
+"225518_x_at",0.70939075283402,0.182318997106959,-1.3768285121241,-5.0562885775248,-0.937774678205659,"MTHFD1L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like",TRUE
+"1561125_at",0.791646964605038,0.32223675781832,1.01248309257249,-5.45235020161066,0.440540887342147,"MTHFD1L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like",TRUE
+"234976_x_at",0.945585972037603,0.754583658819801,0.316502611192066,-5.89100989935958,0.0994059474726345,"MTHFD2","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase",TRUE
+"201761_at",0.967489765978409,0.847611451508473,0.194429256970643,-5.92128791685339,0.0680843198036314,"MTHFD2","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase",TRUE
+"233083_at",0.472863217746026,0.0258507207653017,2.38868523795177,-3.48741522401393,1.25153946137035,"MTHFD2L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like",TRUE
+"239562_at",0.635174103121116,0.106004380941094,-1.68509892692193,-4.64387119143303,-1.22764345252137,"MTHFD2L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like",TRUE
+"235748_s_at",0.766438030219119,0.267058270026601,1.13853505838409,-5.32730514828931,0.954305642828988,"MTHFD2L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like",TRUE
+"220346_at",0.835838027302116,0.415427098358512,0.829937558908165,-5.60965188224584,0.717740197379019,"MTHFD2L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like",TRUE
+"238762_at",0.923376218980614,0.671135651726931,-0.430297606205601,-5.84990097897496,-0.261748794501782,"MTHFD2L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like",TRUE
+"1554841_at",0.946913677125713,0.758931173260065,0.31070204732288,-5.89277354044428,0.228382466560186,"MTHFD2L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like",TRUE
+"1562644_at",0.97443071982529,0.87482224624315,0.159368680928277,-5.92732043411816,0.141362596659403,"MTHFD2L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like",TRUE
+"242370_at",0.979794616772313,0.903625061905432,-0.122477411765044,-5.9323798249696,-0.0699946966116691,"MTHFD2L","methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like",TRUE
+"226929_at",0.623667408398064,0.0947547846973245,-1.74548624895198,-4.555596835938,-0.711677289944522,"MTHFR","methylenetetrahydrofolate reductase (NAD(P)H)",TRUE
+"239035_at",0.769429807058463,0.276931106669008,-1.11468433175228,-5.35196604036132,-0.372346043751797,"MTHFR","methylenetetrahydrofolate reductase (NAD(P)H)",TRUE
+"217071_s_at",0.891653456393983,0.561670732145424,-0.589224926548251,-5.77198217981039,-0.482709443191592,"MTHFR","methylenetetrahydrofolate reductase (NAD(P)H)",TRUE
+"217070_at",0.954054753819891,0.78905565066765,-0.270794632509901,-5.90403025012383,-0.193740098985977,"MTHFR","methylenetetrahydrofolate reductase (NAD(P)H)",TRUE
+"206800_at",0.965619907863942,0.839272494588064,0.205221861504966,-5.91919111781736,0.105696713879656,"MTHFR","methylenetetrahydrofolate reductase (NAD(P)H)",TRUE
+"230442_at",0.616413638398853,0.087249846610674,-1.78928104105046,-4.49014171571194,-1.07406150171067,"MTHFSD","methenyltetrahydrofolate synthetase domain containing",TRUE
+"1554495_s_at",0.774230543658252,0.290162832393946,1.08367079176826,-5.38333972118912,0.582379080995916,"MTHFSD","methenyltetrahydrofolate synthetase domain containing",TRUE
+"222769_at",0.81304218438764,0.362276982362383,-0.930230311558495,-5.52677994641924,-0.305102094623356,"MTHFSD","methenyltetrahydrofolate synthetase domain containing",TRUE
+"1554494_at",0.894272567245808,0.570658541179318,0.575641224105704,-5.77956495523848,0.500436001586698,"MTHFSD","methenyltetrahydrofolate synthetase domain containing",TRUE
+"218879_s_at",0.990797621966014,0.953317379183763,-0.0592077907233966,-5.93797619474472,-0.0166593025153396,"MTHFSD","methenyltetrahydrofolate synthetase domain containing",TRUE
+"244734_at",0.994951215458603,0.976362163658084,0.0299663714579403,-5.93924611559911,0.0141127693353731,"MTHFSD","methenyltetrahydrofolate synthetase domain containing",TRUE
+"203095_at",0.692289844352812,0.161838817098181,1.44721254838793,-4.96801286034053,0.421669282327441,"MTIF2","mitochondrial translational initiation factor 2",TRUE
+"223357_s_at",0.903919439852106,0.605840168686148,-0.5234753423115,-5.80708948917933,-0.286146739967148,"MTIF3","mitochondrial translational initiation factor 3",TRUE
+"223356_s_at",0.984726013444734,0.925109272883173,0.0950757735352411,-5.93528167982515,0.0428787720534398,"MTIF3","mitochondrial translational initiation factor 3",TRUE
+"204101_at",0.42796179417767,0.0185891063511399,-2.54027238801345,-3.20705913871165,-1.37008964532165,"MTM1","myotubularin 1",TRUE
+"36920_at",0.661974206478491,0.129326141830977,-1.57544283584632,-4.79808897263103,-0.772303105375229,"MTM1","myotubularin 1",TRUE
+"216095_x_at",0.784925710185113,0.310106001985168,-1.03879086557557,-5.42733829330273,-0.396108171497811,"MTMR1","myotubularin related protein 1",TRUE
+"214975_s_at",0.854400503339099,0.465927033112329,-0.741922178684103,-5.67507876579116,-0.387927521980346,"MTMR1","myotubularin related protein 1",TRUE
+"213511_s_at",0.891918115867831,0.562030672363151,-0.588678792666631,-5.77229034693415,-0.199932049599042,"MTMR1","myotubularin related protein 1",TRUE
+"216303_s_at",0.950926616697165,0.775965013585832,0.288077443090829,-5.89934342579296,0.183144091332777,"MTMR1","myotubularin related protein 1",TRUE
+"225810_at",0.901885429598207,0.599944197544056,-0.53211189924858,-5.80270799005849,-0.182837805425363,"MTMR10","myotubularin related protein 10",TRUE
+"220286_at",0.937113154905832,0.720583007534652,-0.362269650754484,-5.87596303085755,-0.221645846247627,"MTMR10","myotubularin related protein 10",TRUE
+"205076_s_at",0.898111726390495,0.587111281657962,0.551053559951847,-5.79285440201885,0.219067743276472,"MTMR11","myotubularin related protein 11",TRUE
+"1556034_s_at",0.990810941805126,0.953518882042006,0.0589519133965351,-5.93799091832392,0.0295286733815621,"MTMR11","myotubularin related protein 11",TRUE
+"220953_s_at",0.66932922090261,0.13538719304866,1.54967110315714,-4.83316038018241,0.511786148878821,"MTMR12","myotubularin related protein 12",TRUE
+"225232_at",0.796057358290489,0.328236252131702,0.999727310728904,-5.46426860089363,0.342922553814809,"MTMR12","myotubularin related protein 12",TRUE
+"222143_s_at",0.844245372791972,0.440922460654069,-0.784729285550688,-5.64412000666652,-0.26248381590325,"MTMR14","myotubularin related protein 14",TRUE
+"232342_at",0.890553592605148,0.559272033053563,0.592869083393356,-5.76991881791912,0.313299714652571,"MTMR14","myotubularin related protein 14",TRUE
+"214649_s_at",0.514490373584066,0.0347375426186754,2.24958297401311,-3.73614605183304,1.17473459270905,"MTMR2","myotubularin related protein 2",TRUE
+"203212_s_at",0.621591875129701,0.0919584141544313,1.76144399314363,-4.53188459006278,0.817558365773371,"MTMR2","myotubularin related protein 2",TRUE
+"203211_s_at",0.676294804179428,0.143030564873156,1.5184953289328,-4.87497370198888,0.827314458636716,"MTMR2","myotubularin related protein 2",TRUE
+"211507_s_at",0.693850056112024,0.163122584752217,-1.4425968019511,-4.9739123969621,-0.825638136354325,"MTMR3","myotubularin related protein 3",TRUE
+"202197_at",0.774230543658252,0.287626593691885,-1.08953502601552,-5.37746779753278,-0.323042169473293,"MTMR3","myotubularin related protein 3",TRUE
+"202198_s_at",0.911468038523269,0.629783988282251,-0.488803791805175,-5.82397519256814,-0.177868669100169,"MTMR3","myotubularin related protein 3",TRUE
+"226956_at",0.922908550456534,0.669849535544701,-0.432093410426223,-5.84915337477036,-0.149583893247779,"MTMR3","myotubularin related protein 3",TRUE
+"214268_s_at",0.819807973515613,0.377790289829414,-0.900015635838397,-5.55266697932218,-0.371780618825769,"MTMR4","myotubularin related protein 4",TRUE
+"212277_at",0.894538680437601,0.5711279727866,-0.574934768006306,-5.77995463347752,-0.228270522786504,"MTMR4","myotubularin related protein 4",TRUE
+"214429_at",0.768104086648568,0.27126331612432,-1.12829895474253,-5.33794546833184,-0.481727734446965,"MTMR6","myotubularin related protein 6",TRUE
+"228789_at",0.998870448604467,0.996422371053247,-0.00453477101365375,-5.9396734647157,-0.00194360528906223,"MTMR6","myotubularin related protein 6",TRUE
+"217292_at",0.715119690416591,0.190842948915036,-1.34938009577679,-5.08972487473724,-0.668356121378415,"MTMR7","myotubularin related protein 7",TRUE
+"243804_at",0.819018525257656,0.373359764038014,0.908559505005907,-5.54542680947353,0.60847510687439,"MTMR7","myotubularin related protein 7",TRUE
+"215793_at",0.867447813467579,0.499925545411556,0.685844146930305,-5.71313846360304,0.608258605065714,"MTMR7","myotubularin related protein 7",TRUE
+"233101_at",0.835952408568777,0.415894391587012,0.82909357526238,-5.61031193147029,0.533644465446643,"MTMR9","myotubularin related protein 9",TRUE
+"213278_at",0.955730092376044,0.797759329232235,-0.259350456573945,-5.90697531750181,-0.075937032544557,"MTMR9","myotubularin related protein 9",TRUE
+"204837_at",0.962795886672571,0.830760339196194,-0.21626441481451,-5.91692903362127,-0.0693857089208212,"MTMR9","myotubularin related protein 9",TRUE
+"244718_at",0.547343369043481,0.0477759035031415,2.09542645180981,-4.00121051487289,1.26132313523475,"MTMR9LP","myotubularin related protein 9-like, pseudogene",TRUE
+"228593_at",0.843095426822889,0.437275807366047,0.791094394400324,-5.63937680514267,0.869124827896314,"MTMR9LP","myotubularin related protein 9-like, pseudogene",TRUE
+"221369_at",0.857316604145187,0.472548189680275,0.730818369935175,-5.68284053822346,0.452157511928869,"MTNR1A","melatonin receptor 1A",TRUE
+"208516_at",0.630603891142543,0.101761319029488,1.70720400697765,-4.61182789257644,0.891478736207798,"MTNR1B","melatonin receptor 1B",TRUE
+"235975_at",0.760237493549547,0.258310801679513,-1.16021468236887,-5.304490206426,-0.391138248373503,"MTO1","mitochondrial tRNA translation optimization 1",TRUE
+"218716_x_at",0.825047202440591,0.392446320875582,0.87221268149702,-5.57578888212356,0.371304045621704,"MTO1","mitochondrial tRNA translation optimization 1",TRUE
+"233665_x_at",0.839519981963042,0.427141423401085,0.808957422418181,-5.62587307676925,0.318307199575738,"MTO1","mitochondrial tRNA translation optimization 1",TRUE
+"222014_x_at",0.91676531736797,0.648226061132869,0.462509332889322,-5.8360271073926,0.178908777726985,"MTO1","mitochondrial tRNA translation optimization 1",TRUE
+"224430_s_at",0.97689149311934,0.889385240673793,0.140691067564287,-5.93004716081285,0.0605894306418904,"MTO1","mitochondrial tRNA translation optimization 1",TRUE
+"215381_at",0.937113154905832,0.720860070107097,-0.361893638286652,-5.87609482232142,-0.275924040605322,"MTOR","mechanistic target of rapamycin",TRUE
+"202288_at",0.960857829396113,0.822076041033221,-0.227558708824871,-5.91449333325714,-0.0594847979540276,"MTOR","mechanistic target of rapamycin",TRUE
+"218947_s_at",0.750807729565285,0.243795894543828,1.19742264119306,-5.26445634270881,0.309759128296925,"MTPAP","mitochondrial poly(A) polymerase",TRUE
+"233873_x_at",0.782148078497692,0.303924530331721,1.05247618627444,-5.41409864026091,0.304251739909978,"MTPAP","mitochondrial poly(A) polymerase",TRUE
+"229676_at",0.783844746433788,0.306679846246581,1.04635200976698,-5.42004264279704,0.262146218983364,"MTPAP","mitochondrial poly(A) polymerase",TRUE
+"222794_x_at",0.813442508625161,0.363792137528189,0.927241797339673,-5.52937549821842,0.268300592681392,"MTPAP","mitochondrial poly(A) polymerase",TRUE
+"223925_s_at",0.660653511314665,0.128662799972173,1.57832378497427,-4.79414023061934,0.535447980305827,"MTPN","myotrophin",TRUE
+"226969_at",0.538502554109027,0.0439272316657753,-2.13650929211937,-3.93171992883847,-0.716336284628118,"MTR","5-methyltetrahydrofolate-homocysteine methyltransferase",TRUE
+"203774_at",0.979976490833035,0.904393986773572,-0.12149516991899,-5.93249646115625,-0.0459680787997474,"MTR","5-methyltetrahydrofolate-homocysteine methyltransferase",TRUE
+"219822_at",0.820536502908875,0.380471653397454,0.894876898947349,-5.55699114283179,0.282365418976894,"MTRF1","mitochondrial translational release factor 1",TRUE
+"242996_at",0.854116828440652,0.463621019377442,0.74581134744513,-5.67233391870849,0.427577758445748,"MTRF1","mitochondrial translational release factor 1",TRUE
+"244763_at",0.899995753396531,0.594100129833245,0.540713036112308,-5.79827514085968,0.202101987057694,"MTRF1","mitochondrial translational release factor 1",TRUE
+"225215_s_at",0.8288884913487,0.399597340027947,0.858891568204306,-5.58662839536847,0.320829548582863,"MTRF1L","mitochondrial translational release factor 1 like",TRUE
+"217204_at",0.830000544166181,0.401728340723857,0.854951614098956,-5.58980461673698,0.909347897444101,"MTRF1L","mitochondrial translational release factor 1 like",TRUE
+"215560_x_at",0.899808883319249,0.592146060970415,0.543598178396832,-5.79677271975739,0.358089824580065,"MTRF1L","mitochondrial translational release factor 1 like",TRUE
+"225206_s_at",0.934867348047609,0.710817589144386,-0.375557192066784,-5.87121905191901,-0.133136446087095,"MTRF1L","mitochondrial translational release factor 1 like",TRUE
+"203199_s_at",0.683019114815084,0.151930575574554,1.48387031218908,-4.92061691354332,0.537493572208204,"MTRR","5-methyltetrahydrofolate-homocysteine methyltransferase reductase",TRUE
+"203200_s_at",0.797963285726587,0.332214838587972,0.991357212450943,-5.47201469415313,0.564991340706969,"MTRR","5-methyltetrahydrofolate-homocysteine methyltransferase reductase",TRUE
+"210359_at",0.73720080312946,0.223432181228318,1.25254152277327,-5.20313969646541,0.848789448503375,"MTSS1","metastasis suppressor 1",TRUE
+"203036_s_at",0.850984014275628,0.454091607068888,0.762006758347321,-5.66075765573562,0.72730304726745,"MTSS1","metastasis suppressor 1",TRUE
+"210360_s_at",0.851319596585235,0.4553917556713,0.759785196334263,-5.66235952167654,0.496057828949734,"MTSS1","metastasis suppressor 1",TRUE
+"229780_at",0.870433264908839,0.508976327966159,-0.671287078662314,-5.72255160194144,-0.184106669405644,"MTSS1","metastasis suppressor 1",TRUE
+"203037_s_at",0.889836117464942,0.558118883881578,0.594623857418791,-5.76892085904092,0.627281209253539,"MTSS1","metastasis suppressor 1",TRUE
+"1556175_at",0.51470556386048,0.0353085358805968,2.24180672821028,-3.74979220988578,1.85347797885801,"MTSS1L","metastasis suppressor 1 like",TRUE
+"1555894_s_at",0.55937703282623,0.0538001159150298,-2.03672864181431,-4.09898115002393,-1.09786866141301,"MTSS1L","metastasis suppressor 1 like",TRUE
+"213978_at",0.831487912516861,0.405780260764375,-0.847496910854569,-5.5957770358727,-0.797852110911394,"MTSS1L","metastasis suppressor 1 like",TRUE
+"205675_at",0.631299908494113,0.102395957721452,1.70384851708299,-4.61671218599236,1.11713477642698,"MTTP","microsomal triglyceride transfer protein",TRUE
+"226018_at",0.789795896476304,0.318109177486989,1.02135534465943,-5.44397974297073,1.07326830723513,"MTURN","maturin, neural progenitor differentiation regulator homolog (Xenopus)",TRUE
+"227000_at",0.906503120642166,0.614084363645991,0.511466103137699,-5.81306592352348,0.221201864497793,"MTURN","maturin, neural progenitor differentiation regulator homolog (Xenopus)",TRUE
+"239576_at",0.711989638658417,0.186060493660663,1.36465817618964,-5.07118314782956,0.84404856824175,"MTUS1","microtubule associated tumor suppressor 1",TRUE
+"212093_s_at",0.785630329492068,0.311137419827774,1.03652620143179,-5.42951416733053,0.91835297900262,"MTUS1","microtubule associated tumor suppressor 1",TRUE
+"212096_s_at",0.874834820370747,0.521626285602783,0.65118163764017,-5.73523436007914,0.579669453414056,"MTUS1","microtubule associated tumor suppressor 1",TRUE
+"212095_s_at",0.900806750467799,0.596517772426833,0.537149847827937,-5.80011992189684,0.351927651710449,"MTUS1","microtubule associated tumor suppressor 1",TRUE
+"237858_s_at",0.767011398042819,0.268435067799163,1.13517065803173,-5.33081176107623,0.387790900866896,"MTUS2","microtubule associated tumor suppressor candidate 2",TRUE
+"214961_at",0.931455521649454,0.696935832233631,0.394565635833799,-5.8641396600665,0.323972880400142,"MTUS2","microtubule associated tumor suppressor candidate 2",TRUE
+"244676_s_at",0.986611998306681,0.937580130007135,0.0792055674601363,-5.93662834141072,0.0440121715995385,"MTUS2","microtubule associated tumor suppressor candidate 2",TRUE
+"1554755_a_at",0.993773193220256,0.970544256028935,-0.0373451320524419,-5.93900421665533,-0.0228260161943634,"MTUS2","microtubule associated tumor suppressor candidate 2",TRUE
+"1555188_at",0.776955214137673,0.295768999051819,1.07083785478713,-5.39609075449684,0.365450882072792,"MTUS2-AS1","MTUS2 antisense RNA 1",TRUE
+"210386_s_at",0.601115828839805,0.076788447139783,-1.85610077346813,-4.38801507584824,-0.562304433505378,"MTX1","metaxin 1",TRUE
+"203517_at",0.648323565874229,0.119488020880171,-1.6194957139691,-4.73709511568304,-0.544620340472768,"MTX2","metaxin 2",TRUE
+"226528_at",0.552420073963858,0.0501014263148982,-2.07202202225971,-4.04041088868206,-0.701096501338663,"MTX3","metaxin 3",TRUE
+"241779_at",0.868397087637799,0.503848843369317,-0.679515912431602,-5.71725426411508,-0.223037517734824,"MTX3","metaxin 3",TRUE
+"207847_s_at",0.872668627020452,0.516208102069257,-0.659759633293004,-5.72986847454269,-0.846527185123204,"MUC1","mucin 1, cell surface associated",TRUE
+"211695_x_at",0.896669076905574,0.581510601351949,-0.55938420525742,-5.7884147722314,-0.563996255110082,"MUC1","mucin 1, cell surface associated",TRUE
+"213693_s_at",0.897375964261386,0.583832233359626,-0.555926106623041,-5.79026553714019,-0.923570362964311,"MUC1","mucin 1, cell surface associated",TRUE
+"226654_at",0.478602853563251,0.0267146441078027,2.37337269288735,-3.5152121363683,0.931709026001501,"MUC12","mucin 12, cell surface associated",TRUE
+"231814_at",0.907340381125046,0.61652679468087,-0.507922896984439,-5.81480337731133,-0.216752384317199,"MUC12","mucin 12, cell surface associated",TRUE
+"218687_s_at",0.915353407558177,0.642970788025957,0.469967767421024,-5.83267481885751,0.419614754734584,"MUC13","mucin 13, cell surface associated",TRUE
+"222712_s_at",0.990810941805126,0.954396485072877,0.057837540687208,-5.93805429770176,0.0597840352170174,"MUC13","mucin 13, cell surface associated",TRUE
+"227238_at",0.966769992359004,0.845352304309521,0.197350746278545,-5.92073146295853,0.285128117487345,"MUC15","mucin 15, cell surface associated",TRUE
+"227241_at",0.9941582295447,0.973392186892344,-0.0337329067466218,-5.9391292624287,-0.0452301500467156,"MUC15","mucin 15, cell surface associated",TRUE
+"220196_at",0.071020853517731,0.000204747385334916,4.4363989718245,0.741883151595491,5.29985464279131,"MUC16","mucin 16, cell surface associated",TRUE
+"232407_at",0.552420073963858,0.0500766825695863,2.07226587583958,-4.04000392507491,0.848726613022674,"MUC17","mucin 17, cell surface associated",TRUE
+"232321_at",0.898609426925686,0.587997443869343,-0.549739071846723,-5.79354902090788,-0.267802950432981,"MUC17","mucin 17, cell surface associated",TRUE
+"1553436_at",0.97897951922649,0.898038180968335,-0.129617989164732,-5.93150373082554,-0.133397477318724,"MUC19","mucin 19, oligomeric",TRUE
+"204673_at",0.667641453131852,0.134064439668333,1.55521283658393,-4.8256573684621,1.0323798339316,"MUC2","mucin 2, oligomeric mucus/gel-forming",TRUE
+"226622_at",0.628240182599906,0.09957375534693,1.71890836015611,-4.59473458226839,2.38297894836902,"MUC20","mucin 20, cell surface associated",TRUE
+"231941_s_at",0.64513208805899,0.115753484827415,1.63701482158338,-4.71247742838293,2.49023687422636,"MUC20","mucin 20, cell surface associated",TRUE
+"243774_at",0.725583196024696,0.20446289357774,1.30745715854261,-5.13970176788814,1.12880595131053,"MUC20","mucin 20, cell surface associated",TRUE
+"230043_at",0.979347742195592,0.900503731729773,0.126465947009398,-5.93189657153987,0.142377897994749,"MUC20","mucin 20, cell surface associated",TRUE
+"233993_at",0.904832003218088,0.610252211540408,-0.517038780425784,-5.81030947151335,-0.401572480002439,"MUC3","intestinal mucin-like",TRUE
+"233891_at",0.907111393934291,0.615672615120332,0.509161294052723,-5.81419745343149,0.23915847622541,"MUC3","intestinal mucin-like",TRUE
+"217054_at",0.55679801038721,0.0520691605257612,-2.0529664526968,-4.07211590340133,-1.21347236714776,"MUC3A","mucin 3A, cell surface associated",TRUE
+"214676_x_at",0.725168361556674,0.203496158547649,-1.31035972592401,-5.13628445162702,-0.969685096916788,"MUC3B","mucin 3B, cell surface associated",TRUE
+"214898_x_at",0.984726013444734,0.925093559386696,-0.0950957851819907,-5.9352798270427,-0.103518375426636,"MUC3B","mucin 3B, cell surface associated",TRUE
+"217117_x_at",0.959203345279235,0.815298825122209,-0.236393761421534,-5.91250200746595,-0.0966670704603869,"MUC3B///MUC3A","mucin 3B, cell surface associated///mucin 3A, cell surface associated",TRUE
+"217109_at",0.419170456955056,0.0172038135419688,2.57538065108275,-3.14085241539655,2.92987183856928,"MUC4","mucin 4, cell surface associated",TRUE
+"204895_x_at",0.528176582660474,0.0407929897983378,2.17243869558713,-3.87025037083815,2.02809133127109,"MUC4","mucin 4, cell surface associated",TRUE
+"217110_s_at",0.571736836402345,0.0597484373303448,1.98426533354347,-4.18481112047027,2.79831496542482,"MUC4","mucin 4, cell surface associated",TRUE
+"235055_x_at",0.623503825356688,0.0941217206014796,1.74906319215777,-4.55029556506836,0.563276580068202,"MUC4","mucin 4, cell surface associated",TRUE
+"1561785_at",0.665711654383562,0.132910990749903,1.56008226500189,-4.81904717273638,1.40470931622003,"MUC4","mucin 4, cell surface associated",TRUE
+"240164_at",0.940044918888428,0.731451577824933,0.347558700643792,-5.88101834872931,0.2094408250648,"MUC4","mucin 4, cell surface associated",TRUE
+"214385_s_at",0.095161567192087,0.000395092377733951,4.16824194104014,0.162565498864893,2.43308706693871,"MUC5AC","mucin 5AC, oligomeric mucus/gel-forming",TRUE
+"217182_at",0.593337376134677,0.0700091090934424,1.90376975851829,-4.31353649736085,0.686591903111731,"MUC5AC","mucin 5AC, oligomeric mucus/gel-forming",TRUE
+"214303_x_at",0.642051176272454,0.11236923101511,1.6533056515984,-4.689403389753,0.771213941295437,"MUC5AC","mucin 5AC, oligomeric mucus/gel-forming",TRUE
+"217187_at",0.947778780715578,0.761562424669457,-0.307196655027709,-5.89382367543116,-0.172408509554482,"MUC5AC","mucin 5AC, oligomeric mucus/gel-forming",TRUE
+"222268_x_at",0.673366993714442,0.139524442651962,-1.5326214900814,-4.85611110025566,-0.828282291862751,"MUC5B","mucin 5B, oligomeric mucus/gel-forming",TRUE
+"213432_at",0.791949410815258,0.322718479615253,-1.011452810414,-5.45331793055158,-1.43882133305063,"MUC5B","mucin 5B, oligomeric mucus/gel-forming",TRUE
+"1565666_s_at",0.854040699678541,0.463096671757514,0.746697282291627,-5.67170675320628,0.866251666462844,"MUC6","mucin 6, oligomeric mucus/gel-forming",TRUE
+"214133_at",0.986844665519238,0.938493308960303,0.0780443402660628,-5.93671725404136,0.059759116752053,"MUC6","mucin 6, oligomeric mucus/gel-forming",TRUE
+"216359_at",0.820536502908875,0.380229825330532,0.895339375177452,-5.55660291455605,0.672971702809098,"MUC7","mucin 7, secreted",TRUE
+"217059_at",0.887747346625205,0.552928178179693,0.602546159537341,-5.76437989175283,0.454105505254994,"MUC7","mucin 7, secreted",TRUE
+"216671_x_at",0.697172073261335,0.167201371834894,1.42812316098625,-4.99231179853086,0.530208958949522,"MUC8","mucin 8",TRUE
+"217295_at",0.996074388710409,0.980433684502617,-0.0248035646960185,-5.93938383576063,-0.0161754322927976,"MUC8","mucin 8",TRUE
+"1553602_at",0.605913415325856,0.0794291721763425,-1.83852176043382,-4.41514290769304,-3.63950867905503,"MUCL1","mucin like 1",TRUE
+"218246_at",0.812302873476553,0.360852744187707,-0.933047139412486,-5.52432647574044,-0.311889238301401,"MUL1","mitochondrial E3 ubiquitin protein ligase 1",TRUE
+"223347_at",0.527826453640453,0.0404529213548944,-2.17648595064333,-3.86328615902288,-0.741868674067089,"MUM1","melanoma associated antigen (mutated) 1",TRUE
+"223348_x_at",0.715249206041377,0.190929349102403,-1.34910686776466,-5.09005487997218,-0.695512565853962,"MUM1","melanoma associated antigen (mutated) 1",TRUE
+"221290_s_at",0.87106619978761,0.511507072135953,-0.667242749896605,-5.72513250450747,-0.279758490060688,"MUM1","melanoma associated antigen (mutated) 1",TRUE
+"230461_s_at",0.965606225759743,0.839225281058569,-0.205283036914036,-5.9191789110854,-0.1233179536196,"MUM1","melanoma associated antigen (mutated) 1",TRUE
+"229033_s_at",0.971216837324271,0.861771647189483,-0.17615584418052,-5.92458077461593,-0.210917861548292,"MUM1","melanoma associated antigen (mutated) 1",TRUE
+"229160_at",0.973493137611142,0.872340024700195,-0.162557837409068,-5.92682100284209,-0.193548030573027,"MUM1L1","MUM1 like 1",TRUE
+"241749_at",0.974884920935236,0.87702645048024,0.156538139688535,-5.92775543659136,0.162930150209728,"MURC","muscle related coiled-coil protein",TRUE
+"218463_s_at",0.937271400689562,0.721856125533509,-0.360542290999776,-5.87656735063712,-0.101703318804157,"MUS81","MUS81 structure-specific endonuclease subunit",TRUE
+"207633_s_at",0.930899509890345,0.693980823274295,0.39863089376725,-5.8625809241983,0.167024937246195,"MUSK","muscle associated receptor tyrosine kinase",TRUE
+"207632_at",0.940227139261806,0.732410178065404,-0.346264996925071,-5.88145301548,-0.28043399377005,"MUSK","muscle associated receptor tyrosine kinase",TRUE
+"241122_s_at",0.961876388239691,0.826867337555084,-0.221323779859069,-5.91585319856938,-0.103746284134211,"MUSK","muscle associated receptor tyrosine kinase",TRUE
+"202959_at",0.975449397348071,0.882619714882955,0.149361334866628,-5.92882352058485,0.0605161488469772,"MUT","methylmalonyl-CoA mutase",TRUE
+"202960_s_at",0.999359439711187,0.997970298103175,0.00257271257221155,-5.93968025695183,0.000946664726924951,"MUT","methylmalonyl-CoA mutase",TRUE
+"207727_s_at",0.897949253801113,0.586391553843283,0.552121890504921,-5.79228867421709,0.199611426858612,"MUTYH","mutY DNA glycosylase",TRUE
+"227864_s_at",0.816783744453469,0.367816578130494,-0.919344086405293,-5.53619772546441,-0.418312262203854,"MVB12A","multivesicular body subunit 12A",TRUE
+"52975_at",0.484495305292367,0.0278523465074841,-2.35388981727132,-3.55043422758905,-1.60578796912885,"MVB12B","multivesicular body subunit 12B",TRUE
+"221828_s_at",0.676564076407042,0.143566463913571,-1.5163612954923,-4.87781116740321,-1.01662072655455,"MVB12B","multivesicular body subunit 12B",TRUE
+"221687_s_at",0.73148417124022,0.214615840776518,-1.27759850130162,-5.1744819869963,-0.972594624307914,"MVB12B","multivesicular body subunit 12B",TRUE
+"1554065_at",0.802190559985596,0.339852416270563,-0.975481144507783,-5.4865443531427,-0.729967393460619,"MVB12B","multivesicular body subunit 12B",TRUE
+"222241_at",0.959357995170594,0.815959297340062,-0.235531908166742,-5.91269958067695,-0.06950445734177,"MVB12B","multivesicular body subunit 12B",TRUE
+"203027_s_at",0.970274748961658,0.858674630368383,-0.180147012664289,-5.92388919747787,-0.064984651501816,"MVD","mevalonate diphosphate decarboxylase",TRUE
+"204056_s_at",0.718706241731185,0.194674858695587,-1.33735456437299,-5.10419630103105,-0.5835154305071,"MVK","mevalonate kinase",TRUE
+"215649_s_at",0.808266620412549,0.351066481951677,-0.95260732090167,-5.5071017236145,-0.597549507708214,"MVK","mevalonate kinase",TRUE
+"36907_at",0.932091525948902,0.70029014528095,-0.389959230634334,-5.8658868638941,-0.112819011007714,"MVK","mevalonate kinase",TRUE
+"236686_at",0.994098505325585,0.972631630703882,0.0346975250735035,-5.9390971135718,0.0244956069417022,"MVK","mevalonate kinase",TRUE
+"202180_s_at",0.748632141741128,0.241557446205965,1.20330722427464,-5.2580240268323,0.782902797189566,"MVP","major vault protein",TRUE
+"202086_at",0.406049718268978,0.0152204079829628,2.63056374981197,-3.03587962341925,3.38772327041078,"MX1","MX dynamin like GTPase 1",TRUE
+"204994_at",0.0163067060785144,1.04386778737632e-05,5.66473259809183,3.34079726356361,2.92825576778916,"MX2","MX dynamin like GTPase 2",TRUE
+"206877_at",0.599805419912392,0.076323547871571,1.85924988101061,-4.38313601051531,1.38756713202521,"MXD1","MAX dimerization protein 1",TRUE
+"228846_at",0.800342373547779,0.335952046621529,0.983557740763572,-5.47917939850952,0.453922233437661,"MXD1","MAX dimerization protein 1",TRUE
+"226275_at",0.838349550050823,0.423250003176368,0.815886434208411,-5.62055883083245,0.358797708485767,"MXD1","MAX dimerization protein 1",TRUE
+"221250_s_at",0.468735421183467,0.0250704322555112,-2.40292717516177,-3.4614726743191,-1.18038267598784,"MXD3","MAX dimerization protein 3",TRUE
+"202364_at",0.899331416659389,0.589870050635267,0.546964556484719,-5.79500987629621,0.233383167541639,"MXI1","MAX interactor 1, dimerization protein",TRUE
+"209596_at",0.820536502908875,0.380778827518664,0.894289731991237,-5.55748377601056,1.239275696382,"MXRA5","matrix remodeling associated 5",TRUE
+"235836_at",0.560923390313819,0.0544665773248672,2.03060073443811,-4.1090831516454,2.24093693461593,"MXRA7","matrix remodeling associated 7",TRUE
+"212509_s_at",0.597879550155311,0.0751786340242629,1.86707710347516,-4.37098353688133,2.11215369030876,"MXRA7","matrix remodeling associated 7",TRUE
+"227326_at",0.608709711882903,0.081284096788482,1.82647492599567,-4.43362692309186,1.5868997132608,"MXRA7","matrix remodeling associated 7",TRUE
+"228576_s_at",0.868397087637799,0.503141427620321,-0.680654901784576,-5.71651617219054,-0.392511867858516,"MXRA8","matrix remodeling associated 8",TRUE
+"213422_s_at",0.91994485246627,0.659207109160362,-0.447009669499893,-5.84282552692627,-0.292882173336796,"MXRA8","matrix remodeling associated 8",TRUE
+"225673_at",0.304824368772306,0.00595954301906288,-3.04133380017012,-2.2241413531676,-2.13020418334592,"MYADM","myeloid associated differentiation marker",TRUE
+"224920_x_at",0.369429132228615,0.0110185425452588,-2.77423527661181,-2.75769044233367,-1.46485309873336,"MYADM","myeloid associated differentiation marker",TRUE
+"242378_at",0.686998148149102,0.155485985221421,1.4704992076266,-4.93801602345489,1.09521319954018,"MYADML2","myeloid associated differentiation marker like 2",TRUE
+"204798_at",0.780872939723948,0.302651640890538,-1.05531871870392,-5.41132915058219,-1.13330717242698,"MYB","MYB proto-oncogene, transcription factor",TRUE
+"215152_at",0.843475287501313,0.438674103783873,-0.788649876846796,-5.64120269745371,-0.804542854299889,"MYB","MYB proto-oncogene, transcription factor",TRUE
+"233803_s_at",0.51531387545335,0.0358219612405364,2.23491175756849,-3.76186813969958,1.00795546148845,"MYBBP1A","MYB binding protein 1a",TRUE
+"219098_at",0.604682600348682,0.0787663370769696,1.84288584809257,-4.40842544610291,0.613254299168478,"MYBBP1A","MYB binding protein 1a",TRUE
+"213906_at",0.870230575021197,0.508466135338402,-0.672103768596836,-5.72202861623159,-0.563700412582161,"MYBL1","MYB proto-oncogene like 1",TRUE
+"237014_at",0.917806614232276,0.651040640369422,0.458525752482703,-5.83779605708486,0.20908564753344,"MYBL1","MYB proto-oncogene like 1",TRUE
+"231268_at",0.928246500493356,0.68480270072232,0.411301477875789,-5.85762175624564,0.253373923111341,"MYBL1","MYB proto-oncogene like 1",TRUE
+"201710_at",0.729054581881416,0.210562430772555,-1.28938525509092,-5.16083401536076,-0.626958947055186,"MYBL2","MYB proto-oncogene like 2",TRUE
+"214087_s_at",0.871451481476429,0.512850414221871,-0.665100521761086,-5.72649352254069,-0.782883329773185,"MYBPC1","myosin binding protein C, slow type",TRUE
+"206394_at",0.0456100614367249,5.58916162096126e-05,4.96764984345781,1.88186430575983,2.19959857644898,"MYBPC2","myosin binding protein C, fast type",TRUE
+"208040_s_at",0.682539393883246,0.150299649363781,1.4900891584914,-4.91248141399153,0.697660024430374,"MYBPC3","myosin binding protein C, cardiac",TRUE
+"206304_at",0.726636642789909,0.205783631883562,1.30350890848826,-5.14433991236952,0.762110699808946,"MYBPH","myosin binding protein H",TRUE
+"202431_s_at",0.756584150514497,0.251886047376492,1.17648657458757,-5.28711831911588,0.576251594090403,"MYC","v-myc avian myelocytomatosis viral oncogene homolog",TRUE
+"201959_s_at",0.331069603215022,0.00805345353956981,2.91138121619183,-2.48616119517744,0.906192513542848,"MYCBP2","MYC binding protein 2, E3 ubiquitin protein ligase",TRUE
+"1557370_s_at",0.367313270871606,0.0108900742950685,2.77940397275055,-2.74755825986724,0.777782030260932,"MYCBP2","MYC binding protein 2, E3 ubiquitin protein ligase",TRUE
+"201960_s_at",0.508788697903158,0.0337424383831157,2.26341818735535,-3.71179763726809,0.592853989833685,"MYCBP2","MYC binding protein 2, E3 ubiquitin protein ligase",TRUE
+"223731_at",0.308861881799719,0.00645331761656216,-3.0071336396387,-2.29351080694486,-1.42842345774601,"MYCBPAP","MYCBP associated protein",TRUE
+"1562791_at",0.99164669139131,0.960451700072668,0.0501506486139205,-5.93845854857525,0.0365483584418551,"MYCBPAP","MYCBP associated protein",TRUE
+"214058_at",0.822173415758858,0.38614090207702,0.884089682042095,-5.56599382983542,0.512782667804694,"MYCL","v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog",TRUE
+"215491_at",0.869441836317963,0.506625079699476,0.67505466278673,-5.72013387260129,0.424913336941055,"MYCL","v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog",TRUE
+"209757_s_at",0.498396792791655,0.0312259092457518,-2.30014472588238,-3.64673606813549,-2.42398664049957,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"234815_at",0.54295328972902,0.0459325336488919,-2.11471671295991,-3.96868853743514,-1.37355242175652,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"234169_at",0.581406183553129,0.0638803402013249,1.95048554752346,-4.23927494647891,1.32073184188203,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"234298_at",0.662015916975184,0.129957203136735,1.57271344419995,-4.80182476941541,0.935978153424821,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"211377_x_at",0.732320150624823,0.216651655856774,1.27174326627333,-5.18122207284816,0.472718157205005,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"209756_s_at",0.774230543658252,0.288631384823261,1.0872073329105,-5.37980192434598,0.574803094082001,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"234376_at",0.776955214137673,0.295775872465689,-1.07082222847731,-5.39610619829917,-0.414734372286295,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"242026_at",0.825885402662008,0.393464343274622,0.870306759883572,-5.57734925526776,0.32906564290747,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"234872_at",0.897560972979555,0.584589179714612,-0.554800107681046,-5.7908657646959,-0.382363044691297,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"234253_at",0.936318756756998,0.715670449874044,0.368945578069355,-5.87360064017745,0.323005587417813,"MYCN","v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog",TRUE
+"216188_at",0.647518308302168,0.11844368993237,1.62434801164749,-4.73029714970851,1.37927240785196,"MYCNOS","MYCN opposite strand",TRUE
+"207028_at",0.973493137611142,0.872043476441338,0.162938957176366,-5.92676065811684,0.0443576817722997,"MYCNOS","MYCN opposite strand",TRUE
+"244438_at",0.724970327905974,0.202769168776406,1.31254954641504,-5.13370204167735,0.818396221490189,"MYCNUT","MYCN upstream transcript (non-protein coding)",TRUE
+"220471_s_at",0.866000645572812,0.496586232098743,0.69125264424489,-5.70959195884059,0.419126586146055,"MYCT1","myc target 1",TRUE
+"231947_at",0.975794187312778,0.884256036663903,0.147263279760403,-5.9291263158505,0.10734828767973,"MYCT1","myc target 1",TRUE
+"209124_at",0.539609110035715,0.0442777765920007,2.13263594698203,-3.93830814506961,0.820711047974113,"MYD88","myeloid differentiation primary response 88",TRUE
+"216483_s_at",0.774230543658252,0.290117419373026,-1.08377546964168,-5.38323515380619,-0.400551729306788,"MYDGF","myeloid derived growth factor",TRUE
+"221739_at",0.902229953331547,0.600937326112382,-0.530654287435847,-5.80345236078327,-0.181231483203433,"MYDGF","myeloid derived growth factor",TRUE
+"222153_at",0.56861088242915,0.0585858086636097,-1.9941429481566,-4.16876585845845,-1.64856891248871,"MYEF2","myelin expression factor 2",TRUE
+"222772_at",0.930374550176682,0.692122679964785,-0.401190675232942,-5.861591358095,-0.377875997147797,"MYEF2","myelin expression factor 2",TRUE
+"222771_s_at",0.940756067985891,0.734865128625687,-0.342954594046232,-5.88255796906811,-0.448295233902396,"MYEF2","myelin expression factor 2",TRUE
+"229464_at",0.942684843065067,0.743175218833606,-0.331777460925799,-5.886211137108,-0.286327735244039,"MYEF2","myelin expression factor 2",TRUE
+"232676_x_at",0.955203530479627,0.795192270377542,-0.262722048486703,-5.90612078864331,-0.307742491367772,"MYEF2","myelin expression factor 2",TRUE
+"228792_at",0.966593471043185,0.844077671035403,-0.19899985367792,-5.92041370803363,-0.224425162193747,"MYEF2","myelin expression factor 2",TRUE
+"227342_s_at",0.661974206478491,0.129753200930021,1.57359456535679,-4.80061930854694,1.59589364128061,"MYEOV","myeloma overexpressed",TRUE
+"207424_at",0.596382916302699,0.0728177047449778,1.88355168622718,-4.3452875785599,1.52551039236361,"MYF5","myogenic factor 5",TRUE
+"206372_at",0.535243600695458,0.0426712413620459,-2.15062021566731,-3.9076548858218,-0.945672073170596,"MYF6","myogenic factor 6",TRUE
+"205951_at",0.89657270599571,0.581251323945568,-0.559770829583252,-5.78820715983526,-0.475737176447357,"MYH1","myosin heavy chain 1",TRUE
+"213067_at",0.746535697909741,0.238254803979906,1.21206482243347,-5.24840060504442,1.28086719454283,"MYH10","myosin, heavy chain 10, non-muscle",TRUE
+"212372_at",0.756795789115566,0.252190254832125,1.17570919183742,-5.28795306831803,1.0224840090245,"MYH10","myosin, heavy chain 10, non-muscle",TRUE
+"228134_at",0.236027675584494,0.00306069724717706,3.32397708475303,-1.64112443052662,1.8149293254013,"MYH11","myosin heavy chain 11",TRUE
+"201495_x_at",0.757479140651,0.253469148524014,1.17244868031708,-5.29144893188213,0.321825325265958,"MYH11","myosin heavy chain 11",TRUE
+"201496_x_at",0.763445200592777,0.26318154347157,1.14807743470587,-5.31730969080177,0.5236860816387,"MYH11","myosin heavy chain 11",TRUE
+"201497_x_at",0.786851686785014,0.312695208687883,-1.03311580540787,-5.43278277838455,-0.38375658565478,"MYH11","myosin heavy chain 11",TRUE
+"1568760_at",0.866285633130256,0.497145757855108,0.690344972227816,-5.71018900297239,0.590838440957315,"MYH11","myosin heavy chain 11",TRUE
+"228133_s_at",0.902472023022503,0.601450419257773,-0.529901677974234,-5.80383592423566,-0.229887938027208,"MYH11","myosin heavy chain 11",TRUE
+"207961_x_at",0.967976125464292,0.848897800455187,-0.192766548141214,-5.92160091960389,-0.0901686182496331,"MYH11","myosin heavy chain 11",TRUE
+"208208_at",0.935982562460896,0.714004090958514,0.371213948657359,-5.8727882475743,0.343788293218933,"MYH13","myosin heavy chain 13",TRUE
+"217660_at",0.463632028061434,0.02378578580178,2.42729319954771,-3.4168919170459,1.75868436688634,"MYH14","myosin, heavy chain 14, non-muscle",TRUE
+"217545_at",0.51869612539576,0.0371791516310193,2.21710984187332,-3.79294277056708,1.71758129200201,"MYH14","myosin, heavy chain 14, non-muscle",TRUE
+"234290_x_at",0.527546822913581,0.0402132309341703,2.17935713133127,-3.85834078219464,1.24273769428458,"MYH14","myosin, heavy chain 14, non-muscle",TRUE
+"226988_s_at",0.559167054471987,0.0529334855352133,2.04479910832095,-4.08564619225314,1.49192544253814,"MYH14","myosin, heavy chain 14, non-muscle",TRUE
+"232977_x_at",0.572358617934072,0.0600047480200841,1.98211067729089,-4.1883040246597,1.48442232741757,"MYH14","myosin, heavy chain 14, non-muscle",TRUE
+"219946_x_at",0.585036027492332,0.065271191650595,1.9395483954251,-4.25677230705032,1.64254771716589,"MYH14","myosin, heavy chain 14, non-muscle",TRUE
+"215331_at",0.347515673982638,0.0090003809411516,2.86297890392764,-2.58261089698416,0.914981330415642,"MYH15","myosin heavy chain 15",TRUE
+"1564072_at",0.95442332217412,0.790448546749701,0.268960715508187,-5.90451069063016,0.265689355467218,"MYH16","myosin heavy chain 16 pseudogene",TRUE
+"204631_at",0.768852835478002,0.273576238204011,1.12271821421446,-5.34371082352024,0.301753454778679,"MYH2","myosin heavy chain 2",TRUE
+"205940_at",0.874474734833648,0.520733412929282,-0.652591827922237,-5.73435685650678,-0.539581454932278,"MYH3","myosin, heavy chain 3, skeletal muscle, embryonic",TRUE
+"208148_at",0.152865811663982,0.00112403133195653,3.74002490724227,-0.759670028807808,2.33817695997718,"MYH4","myosin heavy chain 4",TRUE
+"214468_at",0.940964444369914,0.735619492016598,-0.341938151122574,-5.8828951338035,-0.210461853060935,"MYH6","myosin heavy chain 6",TRUE
+"216265_x_at",0.75204456742162,0.245193350870742,1.1937694558991,-5.26843576583705,0.683070572509373,"MYH7","myosin, heavy chain 7, cardiac muscle, beta",TRUE
+"204737_s_at",0.962422974805316,0.828758168830133,0.218865716193856,-5.91637897977308,0.0706098711661016,"MYH7///MYH6","myosin, heavy chain 7, cardiac muscle, beta///myosin heavy chain 6",TRUE
+"233949_s_at",0.865677601761371,0.495683388581541,0.692718482058924,-5.70862618555622,0.558493576789983,"MYH7B","myosin heavy chain 7B",TRUE
+"215795_at",0.910165867297668,0.626301130093874,-0.493808507654484,-5.82160753057622,-0.254386828091175,"MYH7B","myosin heavy chain 7B",TRUE
+"34471_at",0.894616046525079,0.571359812137343,0.574585977774477,-5.78014685380916,0.36494184332136,"MYH8","myosin heavy chain 8",TRUE
+"206717_at",0.955892698633978,0.79921948506827,-0.257434050601567,-5.90745614203197,-0.249827196938202,"MYH8","myosin heavy chain 8",TRUE
+"211926_s_at",0.936992192746977,0.718776924967713,0.364722063578948,-5.87510015129869,0.138912236056376,"MYH9","myosin, heavy chain 9, non-muscle",TRUE
+"209888_s_at",0.643688366500038,0.114533035180918,-1.64284296334945,-4.7042426628992,-0.789505132542104,"MYL1","myosin light chain 1",TRUE
+"221660_at",0.702809964629668,0.174608222612367,1.40254875373168,-5.02445052838983,0.663971773302854,"MYL10","myosin light chain 10",TRUE
+"221659_s_at",0.903006708266697,0.602759957266229,-0.527982238330946,-5.80481175765444,-0.147413396961503,"MYL10","myosin light chain 10",TRUE
+"201319_at",0.694819513561858,0.164271614440476,1.43849026034186,-4.97914817853494,0.665734740861653,"MYL12A","myosin light chain 12A",TRUE
+"1555977_at",0.703902004301726,0.175650116488012,1.39902121591763,-5.02884595428177,0.974084705005055,"MYL12A","myosin light chain 12A",TRUE
+"1555978_s_at",0.805127581292656,0.344296487965766,0.966355718356038,-5.49479906689142,0.664053734928806,"MYL12A","myosin light chain 12A",TRUE
+"1555976_s_at",0.941400961503247,0.738018973700614,0.338707480696175,-5.88396020944443,0.376528838490837,"MYL12A","myosin light chain 12A",TRUE
+"221474_at",0.820288124919738,0.378254945833254,0.899123424658612,-5.55341940319061,0.234181438033751,"MYL12B","myosin light chain 12B",TRUE
+"201318_s_at",0.784789297644843,0.309186061791707,1.04081524959526,-5.42538965922183,0.3199952856701,"MYL12B///MYL12A","myosin light chain 12B///myosin light chain 12A",TRUE
+"209742_s_at",0.547343369043481,0.0478653591291631,2.09450744403348,-4.00275512592086,1.42229091062507,"MYL2","myosin light chain 2",TRUE
+"205589_at",0.979588787486838,0.901842790254495,0.12475460182671,-5.93210581305411,0.0740889270361818,"MYL3","myosin light chain 3",TRUE
+"216054_x_at",0.673303044934899,0.138884531152735,1.53523110700826,-4.85261130265805,0.475329003519633,"MYL4","myosin light chain 4",TRUE
+"217274_x_at",0.72050514215489,0.19644692926783,1.33185605130006,-5.11077693081095,0.575985466385602,"MYL4","myosin light chain 4",TRUE
+"210088_x_at",0.85334340854827,0.461500355936149,0.749398095721035,-5.66979045734831,0.244389976154403,"MYL4","myosin light chain 4",TRUE
+"210395_x_at",0.981158705865426,0.911163833593007,-0.112852385109083,-5.93348231305588,-0.0385006791959857,"MYL4","myosin light chain 4",TRUE
+"205145_s_at",0.760563533925384,0.259718098955615,-1.15669061977077,-5.3082245543423,-0.416879167437692,"MYL5","myosin light chain 5",TRUE
+"214002_at",0.776955214137673,0.295624349689187,1.07116676705794,-5.39576563697605,0.352066693860797,"MYL6","myosin light chain 6",TRUE
+"212082_s_at",0.82064687791745,0.381572655334566,-0.892773759144876,-5.55875429373402,-0.179160735016003,"MYL6","myosin light chain 6",TRUE
+"204173_at",0.726696341943087,0.206789960547333,1.30051375035191,-5.147850499264,0.542249188316241,"MYL6B","myosin light chain 6B",TRUE
+"219942_at",0.683019114815084,0.151895163237957,-1.48400476365519,-4.92044131385389,-0.692157543364278,"MYL7","myosin light chain 7",TRUE
+"201058_s_at",0.733934891101761,0.218020929649018,1.26782884295641,-5.18571329944218,2.78120022807218,"MYL9","myosin light chain 9",TRUE
+"244149_at",0.805728806042784,0.345156190586273,0.964599710482369,-5.49637939520829,0.591357692363317,"MYL9","myosin light chain 9",TRUE
+"223130_s_at",0.54295328972902,0.0460525215849275,-2.11344008715592,-3.97084671785803,-1.00054615553587,"MYLIP","myosin regulatory light chain interacting protein",TRUE
+"223129_x_at",0.601886119917951,0.0770218532468043,-1.85452599757683,-4.39045275030079,-1.04807013109958,"MYLIP","myosin regulatory light chain interacting protein",TRUE
+"228098_s_at",0.606900628956089,0.0804483991593092,-1.8318725236899,-4.42535590445036,-1.09488674859993,"MYLIP","myosin regulatory light chain interacting protein",TRUE
+"220319_s_at",0.666643938027574,0.13340223872328,-1.55800414532918,-4.82187018868807,-0.900755045641088,"MYLIP","myosin regulatory light chain interacting protein",TRUE
+"228097_at",0.677509122383198,0.144883240301821,-1.51114527731666,-4.88473310759371,-0.725239943013745,"MYLIP","myosin regulatory light chain interacting protein",TRUE
+"227707_at",0.774230543658252,0.288070539911958,1.08850586137542,-5.37850035545971,0.721427811185417,"MYLIP","myosin regulatory light chain interacting protein",TRUE
+"1568770_at",0.677013732819214,0.144065305817099,-1.51438068854733,-4.88044178362295,-0.786766778487174,"MYLK","myosin light chain kinase",TRUE
+"1569956_at",0.795405659274621,0.327491086436055,1.00130278192152,-5.46280397230235,0.9935560442422,"MYLK","myosin light chain kinase",TRUE
+"1563466_at",0.948668195792872,0.7663273994301,0.300858635521947,-5.8956924228941,0.149377686883286,"MYLK","myosin light chain kinase",TRUE
+"202555_s_at",0.966051687342135,0.841475347745939,0.202368471861373,-5.91975644719165,0.335314784822355,"MYLK","myosin light chain kinase",TRUE
+"224823_at",0.988224361618126,0.943823356449965,0.0712686240860284,-5.93720988429962,0.106125184556591,"MYLK","myosin light chain kinase",TRUE
+"230460_at",0.930899509890345,0.694095037643641,0.398473640415105,-5.8626415121942,0.311453108806138,"MYLK-AS1","MYLK antisense RNA 1",TRUE
+"231792_at",0.97689149311934,0.890089665469127,0.139788967694128,-5.93017028129562,0.045618516284839,"MYLK2","myosin light chain kinase 2",TRUE
+"1568925_at",0.73223722457785,0.216477046146801,1.27224379953168,-5.1806469314985,1.23802202228772,"MYLK3","myosin light chain kinase 3",TRUE
+"1568926_x_at",0.826887378313571,0.395151594340686,0.867154937025132,-5.57992268346151,0.898359153959197,"MYLK3","myosin light chain kinase 3",TRUE
+"1562411_at",0.863548047008085,0.488446493561027,0.704523762345227,-5.70077707782417,0.235772775878786,"MYLK3","myosin light chain kinase 3",TRUE
+"217623_at",0.899808883319249,0.592955741210047,-0.542402137338417,-5.7973964942581,-0.447836997263685,"MYLK3","myosin light chain kinase 3",TRUE
+"238834_at",0.997293485734839,0.986324910509616,0.0173345039584836,-5.93953712663075,0.00538970372366432,"MYLK3","myosin light chain kinase 3",TRUE
+"1561504_s_at",0.565043084457947,0.0562125825093279,2.01485792253247,-4.13494305387179,1.56024674817734,"MYLK4","myosin light chain kinase family member 4",TRUE
+"1556136_at",0.725276957219979,0.204107372369715,1.3085233477267,-5.13844724292222,0.844044485181676,"MYLK4","myosin light chain kinase family member 4",TRUE
+"1561503_at",0.993474831312851,0.969544216720459,0.0386136685255906,-5.93895728821599,0.0159318710975764,"MYLK4","myosin light chain kinase family member 4",TRUE
+"205163_at",0.713633547141264,0.188469848272717,1.3569230270466,-5.08059244397529,0.987970755419173,"MYLPF","myosin light chain, phosphorylatable, fast skeletal muscle",TRUE
+"1566108_at",0.641326159307468,0.111838387694583,1.65589834561653,-4.68571503198859,0.544499273172728,"MYNN","myoneurin",TRUE
+"1566109_at",0.744573608322482,0.235526169125006,1.21936967862458,-5.24032730230993,0.853921805316779,"MYNN","myoneurin",TRUE
+"241730_at",0.782930758690314,0.305430704581775,-1.04912359342904,-5.4173564606888,-0.399158770357519,"MYNN","myoneurin",TRUE
+"218926_at",0.849646596450765,0.451091050825795,-0.767148489249939,-5.6570332367915,-0.279785773882253,"MYNN","myoneurin",TRUE
+"237510_at",0.95297846015397,0.784587209990663,-0.276684321393324,-5.90246537820213,-0.111801818307039,"MYNN","myoneurin",TRUE
+"224206_x_at",0.986564183309744,0.937429948812214,-0.0793965532524546,-5.93661359237301,-0.0245355547001225,"MYNN","myoneurin",TRUE
+"216222_s_at",0.185392143728903,0.00180859049285153,3.54349783347564,-1.17869579901684,3.76434096893823,"MYO10","myosin X",TRUE
+"201976_s_at",0.279325273101419,0.0045338091271277,3.15805245572763,-1.9853637388756,2.63431792764151,"MYO10","myosin X",TRUE
+"244350_at",0.303059342222774,0.00582881341568381,3.05084492851022,-2.20479971099645,2.54657498872534,"MYO10","myosin X",TRUE
+"1554026_a_at",0.34698307261505,0.00897999172840047,2.8639688407902,-2.58064486565011,1.36290937604551,"MYO10","myosin X",TRUE
+"236718_at",0.390155580909671,0.0129873462689639,2.70144588453769,-2.89948296820858,2.62126231043499,"MYO10","myosin X",TRUE
+"220288_at",0.849650943868202,0.451131122388516,0.767079686998262,-5.65708322999749,0.21301606986512,"MYO15A","myosin XVA",TRUE
+"59375_at",0.676306030659334,0.143078771954943,1.51830309276295,-4.87522943455542,0.401311354786935,"MYO15B","myosin XVB",TRUE
+"219173_at",0.784925710185113,0.310225399596506,1.03852843485261,-5.42759065406536,0.451552863811263,"MYO15B","myosin XVB",TRUE
+"227743_at",0.841738669284112,0.433608955105386,0.797527778756578,-5.63454608622275,0.515767770206476,"MYO15B","myosin XVB",TRUE
+"215119_at",0.748067267263424,0.239956414988727,1.20754132888594,-5.25337887547695,0.386539794439768,"MYO16","myosin XVI",TRUE
+"1557720_s_at",0.841550580403629,0.433231727343355,0.798191515841928,-5.63404560330652,0.478566370056241,"MYO16","myosin XVI",TRUE
+"202039_at",0.744573608322482,0.235875513168124,1.21843088831532,-5.24136720177104,0.540155318914518,"MYO18A///TIAF1","myosin XVIIIA///TGFB1-induced anti-apoptotic factor 1",TRUE
+"1554579_a_at",0.683017520100356,0.151328371975856,1.4861602024242,-4.91762446381614,1.51502347351813,"MYO18B","myosin XVIIIB",TRUE
+"234598_at",0.603856141249418,0.0784267482215293,1.84513407110281,-4.40496041289041,0.57737778864325,"MYO19","myosin XIX",TRUE
+"236022_at",0.731054546207485,0.214095485204187,1.27910196311662,-5.17274705891835,0.679578550861403,"MYO19","myosin XIX",TRUE
+"225947_at",0.886567073863495,0.549535559893559,0.607745197966977,-5.76136833208159,0.226172923671786,"MYO19","myosin XIX",TRUE
+"219320_at",0.93667390723462,0.717280990658,-0.366755063774541,-5.87438048481086,-0.132826600566583,"MYO19","myosin XIX",TRUE
+"211916_s_at",0.966593471043185,0.844744711283077,0.198136773750268,-5.92058033739961,0.0764557366692129,"MYO1A","myosin IA",TRUE
+"212365_at",0.851733415458562,0.456006716891026,0.758735742723898,-5.66311469613309,0.517540121374948,"MYO1B","myosin IB",TRUE
+"212364_at",0.854400503339099,0.46559749744239,0.74247724984658,-5.67468784712883,0.534633105102735,"MYO1B","myosin IB",TRUE
+"215074_at",0.986889306520757,0.938836807479466,-0.0776075652481966,-5.93675035729768,-0.0681675252055891,"MYO1B","myosin IB",TRUE
+"214656_x_at",0.753862100951903,0.247157709443321,1.18866059217065,-5.27398310624818,0.439997518160622,"MYO1C","myosin IC",TRUE
+"32811_at",0.768852835478002,0.273492768607148,1.1229190128893,-5.3435038207363,0.330143058381765,"MYO1C","myosin IC",TRUE
+"225080_at",0.879948283821082,0.534827069738538,0.630484546425952,-5.74790343898372,0.219817932781037,"MYO1C","myosin IC",TRUE
+"212338_at",0.854163696308241,0.46380333029632,0.745503455729816,-5.67255171429439,1.03155562879932,"MYO1D","myosin ID",TRUE
+"1555397_at",0.991654201885031,0.960693914320006,0.0498432333231415,-5.93847351892088,0.0264081885505787,"MYO1D","myosin ID",TRUE
+"203072_at",0.322755079756926,0.00730220454795277,2.95382150971391,-2.40106660689239,1.23296493254976,"MYO1E","myosin IE",TRUE
+"213733_at",0.948684674264832,0.766712975808513,0.300346323384417,-5.89584178986105,0.234635011676594,"MYO1F","myosin IF",TRUE
+"227799_at",0.653206225743412,0.122648653195828,1.60502350686975,-4.75727690902021,0.656495835409435,"MYO1G","myosin IG",TRUE
+"244654_at",0.838682969007165,0.423917281564564,0.814695469026965,-5.6214752740098,0.379098911484742,"MYO1G","myosin IG",TRUE
+"1553452_at",0.975624333648212,0.883723543323227,-0.147945956032343,-5.92902825985541,-0.0643294216053816,"MYO1H","myosin IH",TRUE
+"244364_at",0.715404292979582,0.191140848867778,-1.3484384407223,-5.090861971395,-0.682464056255485,"MYO3A","myosin IIIA",TRUE
+"221400_at",0.888972420461865,0.556486836102014,-0.59711060769055,-5.76750173603599,-0.345031776852411,"MYO3A","myosin IIIA",TRUE
+"1569186_at",0.907871409554181,0.61751860722287,0.506485967250576,-5.81550463550343,0.342017273274556,"MYO3A","myosin IIIA",TRUE
+"1552578_a_at",0.659382629906731,0.127297045605753,-1.58429443123869,-4.7859386626987,-1.63947419964955,"MYO3B","myosin IIIB",TRUE
+"1560788_at",0.959650680479973,0.818019872436243,0.232844222735807,-5.91331110215494,0.193043425329937,"MYO3B","myosin IIIB",TRUE
+"1555257_a_at",0.961212424803935,0.823077019110054,0.226255378909487,-5.91478070297848,0.180613454298625,"MYO3B","myosin IIIB",TRUE
+"241966_at",0.919156359329732,0.655757331657519,0.451866852671514,-5.84071952193121,0.323256716614075,"MYO5A","myosin VA",TRUE
+"204527_at",0.933922051839063,0.707239623444365,-0.380442794734228,-5.8694323867858,-0.246738916761531,"MYO5A","myosin VA",TRUE
+"217417_at",0.959203345279235,0.815152753617201,-0.236584395503115,-5.91245820913367,-0.199131039953566,"MYO5A","myosin VA",TRUE
+"227761_at",0.97928472590149,0.899250834233353,0.128067526830308,-5.93169817238853,0.0838404867312086,"MYO5A","myosin VA",TRUE
+"1570141_at",0.89767014756104,0.584791016267079,0.554499987279954,-5.79102554816799,0.309239802171134,"MYO5B","myosin VB",TRUE
+"225301_s_at",0.934081042629428,0.708425505068197,-0.378822470639688,-5.87002746359623,-0.206615506543658,"MYO5B","myosin VB",TRUE
+"225299_at",0.947969282616012,0.763634023865491,-0.304439603238235,-5.89464132934895,-0.176441604940807,"MYO5B","myosin VB",TRUE
+"218966_at",0.899808883319249,0.592112803229208,-0.543647323109115,-5.79674706062223,-0.407506398449536,"MYO5C","myosin VC",TRUE
+"203215_s_at",0.82131886346615,0.382666241023076,0.890688722170026,-5.56049847709506,0.662088734261435,"MYO6","myosin VI",TRUE
+"210480_s_at",0.929332398252332,0.689366379597638,0.404992795550883,-5.86011001584956,0.229198239941315,"MYO6","myosin VI",TRUE
+"203216_s_at",0.948429371744093,0.765221352976055,0.302328686972699,-5.89526242171459,0.174607647233694,"MYO6","myosin VI",TRUE
+"33197_at",0.61362348304466,0.0847740677123028,1.804441090002,-4.46720811681311,0.56702939067306,"MYO7A","myosin VIIA",TRUE
+"211103_at",0.660234446131062,0.128252285254957,-1.58011286830626,-4.79168520072363,-0.835114053130428,"MYO7A","myosin VIIA",TRUE
+"208189_s_at",0.774371547012978,0.290642496867916,-1.08256587492194,-5.3844429221586,-0.407699084537629,"MYO7A","myosin VIIA",TRUE
+"211104_s_at",0.849935057946582,0.451860146483436,0.765828608625849,-5.65799155179345,0.55888345807147,"MYO7A","myosin VIIA",TRUE
+"216662_at",0.774230543658252,0.288561965152375,1.08736796215767,-5.37964099405745,0.70461187624898,"MYO7B","myosin VIIB",TRUE
+"216660_at",0.799039781143356,0.33369898215195,-0.988252633147217,-5.47487277164236,-0.446654173105934,"MYO7B","myosin VIIB",TRUE
+"235383_at",0.942961933269639,0.744094592097381,0.330543567210332,-5.88660708792872,0.246543808176693,"MYO7B","myosin VIIB",TRUE
+"242512_at",0.737123149977386,0.222585689934425,1.25491409801893,-5.20044701694045,0.458367569129857,"MYO9A","myosin IXA",TRUE
+"226203_at",0.77796164470392,0.297048777734701,-1.06793281865042,-5.39895839504028,-0.413403680898211,"MYO9A","myosin IXA",TRUE
+"219027_s_at",0.822170583627284,0.385995953864045,0.884364188857727,-5.56576598916747,0.357765400992962,"MYO9A","myosin IXA",TRUE
+"217297_s_at",0.760323325310287,0.258947976965759,1.15861735266753,-5.30618408609578,0.509096893960066,"MYO9B","myosin IXB",TRUE
+"208452_x_at",0.773234064853267,0.284158977492645,1.0976134338837,-5.36933257912938,0.373685525455645,"MYO9B","myosin IXB",TRUE
+"214780_s_at",0.897519105381791,0.584310792063372,0.555214140109957,-5.79064519694754,0.173750713244182,"MYO9B","myosin IXB",TRUE
+"210155_at",0.980067566136987,0.906420803298374,-0.118906653034595,-5.93279934187862,-0.0518490644413454,"MYOC","myocilin",TRUE
+"237206_at",0.768852835478002,0.273887041269943,1.12197092403681,-5.3444809150949,0.915363601576013,"MYOCD","myocardin",TRUE
+"229339_at",0.872668627020452,0.516245104111288,0.659700883793602,-5.72990545379504,0.202192851160544,"MYOCD","myocardin",TRUE
+"206657_s_at",0.517348414110187,0.0365423647704797,2.22538744064453,-3.77851226673292,0.884005074224611,"MYOD1","myogenic differentiation 1",TRUE
+"211864_s_at",0.540483367247649,0.0450250440835692,2.12447044008932,-3.95217216891304,1.2254828306389,"MYOF","myoferlin",TRUE
+"201798_s_at",0.6181505942496,0.0891168532585664,1.77809218018847,-4.50697744381253,0.941358607216214,"MYOF","myoferlin",TRUE
+"217518_at",0.763650705722297,0.263621653245228,1.14698893638422,-5.31845358262835,0.824819043045128,"MYOF","myoferlin",TRUE
+"207282_s_at",0.55937703282623,0.0535506495430112,2.03903983005275,-4.0951658863215,0.883824155076769,"MYOG","myogenin (myogenic factor 4)",TRUE
+"205610_at",0.832387886813814,0.408574187808364,-0.842384312584537,-5.59984484366232,-0.652485973766125,"MYOM1","myomesin 1",TRUE
+"205826_at",0.675622576285316,0.142040773662617,1.52245413133791,-4.86970155356653,1.53348177455185,"MYOM2","myomesin 2",TRUE
+"238124_at",0.792436690618566,0.323811386513602,1.00911932445106,-5.45550644071793,0.278371465705304,"MYOM3","myomesin 3",TRUE
+"230284_at",0.934352397958111,0.7091679160579,-0.377808606371774,-5.87039853917616,-0.250985678112281,"MYOM3","myomesin 3",TRUE
+"219728_at",0.740587184077449,0.229865405436519,1.23473090140758,-5.22321339334626,1.06951244593006,"MYOT","myotilin",TRUE
+"219509_at",0.895690630367785,0.576308245870841,0.567158362557421,-5.78421342279765,0.404560918647076,"MYOZ1","myozenin 1",TRUE
+"213782_s_at",0.689848451630875,0.158893280897508,1.457915876637,-4.95427358528839,0.510742738373926,"MYOZ2","myozenin 2",TRUE
+"207148_x_at",0.774011928861764,0.285783574829809,1.0938198420288,-5.37315951185411,0.490508763748611,"MYOZ2","myozenin 2",TRUE
+"211476_at",0.884332704164424,0.543422529102138,-0.617156086858364,-5.75585357183573,-0.493862340180454,"MYOZ2","myozenin 2",TRUE
+"1553071_a_at",0.571736836402345,0.0597872489049894,1.98393854146597,-4.18534104641902,1.2965301561914,"MYOZ3","myozenin 3",TRUE
+"1553070_a_at",0.728385463227073,0.209469139441214,1.29259438481438,-5.15709967563655,0.749979433809409,"MYOZ3","myozenin 3",TRUE
+"1562002_at",0.861113073516266,0.481340419193249,0.716214124529043,-5.69287984619272,0.380856911910485,"MYOZ3","myozenin 3",TRUE
+"213955_at",0.961146128665821,0.822655639103225,-0.226803990471545,-5.91465994041509,-0.178055638511751,"MYOZ3","myozenin 3",TRUE
+"1562004_x_at",0.989524702314661,0.948698680999933,0.0650739658151034,-5.9376211634341,0.0309661533378973,"MYOZ3","myozenin 3",TRUE
+"235367_at",0.70239414369209,0.173789331885283,1.40533307468133,-5.02097472756748,1.41161985899349,"MYPN","myopalladin",TRUE
+"227937_at",0.743474458360704,0.233804495884419,-1.2240117736215,-5.23517506717741,-0.394364204929706,"MYPOP","Myb related transcription factor, partner of profilin",TRUE
+"204073_s_at",0.341198907110782,0.00853075273928558,2.88634248139838,-2.53613652473185,1.97502474779068,"MYRF","myelin regulatory factor",TRUE
+"217462_at",0.943464796017993,0.74642574090896,-0.327417264708439,-5.88760376836808,-0.264993253730801,"MYRF","myelin regulatory factor",TRUE
+"217463_s_at",0.945498722604777,0.754308072655305,0.316870676808852,-5.89089690016115,0.142849511300409,"MYRF","myelin regulatory factor",TRUE
+"1556267_at",0.739367922105944,0.227158812255756,-1.24217731186521,-5.21485090026374,-1.77235133988076,"MYRFL","myelin regulatory factor-like",TRUE
+"242730_at",0.317600554649094,0.00692841249697539,2.97652210491728,-2.35535698490588,0.759326641806766,"MYRIP","myosin VIIA and Rab interacting protein",TRUE
+"214156_at",0.793357022908103,0.325120392414796,-1.00633164752109,-5.45811491991787,-1.21616973448301,"MYRIP","myosin VIIA and Rab interacting protein",TRUE
+"225760_at",0.812302873476553,0.360461744279085,-0.933821754068985,-5.52365058735046,-0.321653404247947,"MYSM1","Myb like, SWIRM and MPN domains 1",TRUE
+"238644_at",0.864894115958506,0.493604737055378,-0.696099141857246,-5.7063913788874,-0.254016424996196,"MYSM1","Myb like, SWIRM and MPN domains 1",TRUE
+"1569706_at",0.957430653957785,0.807629729053601,0.246414799351332,-5.91015208226789,0.110646031789249,"MYSM1","Myb like, SWIRM and MPN domains 1",TRUE
+"210341_at",0.751464513744428,0.244546229955758,-1.19545919129322,-5.26659644820364,-1.14468102448282,"MYT1","myelin transcription factor 1",TRUE
+"1556269_at",0.803566977998733,0.341762294115871,-0.971549476875071,-5.49010955721338,-0.715645121875949,"MYT1","myelin transcription factor 1",TRUE
+"215822_x_at",0.973493137611142,0.872242935093792,0.162682612926957,-5.92680126198834,0.0552428383074188,"MYT1","myelin transcription factor 1",TRUE
+"241485_at",0.599884666181457,0.0763926104036154,1.85878101423224,-4.3838628203546,1.08640970744496,"MYT1L","myelin transcription factor 1 like",TRUE
+"210016_at",0.766479227854582,0.26713400104268,1.13834966814847,-5.32749861313769,0.825773446478949,"MYT1L","myelin transcription factor 1 like",TRUE
+"1554633_a_at",0.849935057946582,0.45190490505648,-0.765751838201409,-5.65804724389224,-0.648313652407154,"MYT1L","myelin transcription factor 1 like",TRUE
+"216672_s_at",0.95238233774064,0.78218880694829,-0.279849683123891,-5.90161054368698,-0.212513051382394,"MYT1L","myelin transcription factor 1 like",TRUE
+"228568_at",0.585036027492332,0.0656209746312681,1.936830174214,-4.26111046452635,0.966720680174012,"MYZAP","myocardial zonula adherens protein",TRUE
+"212241_at",0.54295328972902,0.0458083110247832,-2.11604155951521,-3.96644796035995,-0.582592850832022,"MYZAP///GCOM1///POLR2M","myocardial zonula adherens protein///GRINL1A complex locus 1///RNA polymerase II subunit M",TRUE
+"221286_s_at",0.762729892034689,0.262321439639699,-1.15020856278162,-5.31506734675431,-1.04828535239499,"MZB1","marginal zone B and B1 cell specific protein",TRUE
+"223565_at",0.778580821633075,0.298810552731896,-1.06394826764736,-5.402880309986,-1.06931157359526,"MZB1","marginal zone B and B1 cell specific protein",TRUE
+"204138_s_at",0.888610474399596,0.554863495125783,-0.599587864817607,-5.76608234169492,-0.443975865600938,"MZF1","myeloid zinc finger 1",TRUE
+"204139_x_at",0.932415412515157,0.701936019280254,-0.387702131144728,-5.86673559824066,-0.18769799517065,"MZF1","myeloid zinc finger 1",TRUE
+"210336_x_at",0.94895689004559,0.767650985028995,0.29910034054089,-5.89620400864808,0.167836966800147,"MZF1","myeloid zinc finger 1",TRUE
+"40569_at",0.954054753819891,0.78922619955226,0.270570033324726,-5.9040892637102,0.119349335525596,"MZF1","myeloid zinc finger 1",TRUE
+"1568864_at",0.893621769721663,0.568975967947883,0.578175794675063,-5.77816308303816,0.346434696905611,"MZF1-AS1","MZF1 antisense RNA 1",TRUE
+"228530_at",0.544577979658206,0.0467014354501883,2.10658730072891,-3.98241737580948,0.765199242571513,"MZT1","mitotic spindle organizing protein 1",TRUE
+"225578_at",0.678126513742682,0.145397090292465,1.50912033935657,-4.88741517449337,0.536264143890246,"MZT1","mitotic spindle organizing protein 1",TRUE
+"212995_x_at",0.481363249480408,0.0273108287980357,-2.36306985206607,-3.53385850118826,-0.608430527672809,"MZT2A///MZT2B///PHGDH","mitotic spindle organizing protein 2A///mitotic spindle organizing protein 2B///phosphoglycerate dehydrogenase",TRUE
+"220720_x_at",0.646692716816097,0.11773414042582,-1.62766529844018,-4.72564067660954,-0.69960688395497,"MZT2B","mitotic spindle organizing protein 2B",TRUE
+"221867_at",0.937271400689562,0.721850568679355,0.360549828077965,-5.87656471997299,0.182277940114631,"N4BP1","NEDD4 binding protein 1",TRUE
+"204601_at",0.943988850936011,0.749672440013065,0.323068649874545,-5.88897453852228,0.165109229111138,"N4BP1","NEDD4 binding protein 1",TRUE
+"32069_at",0.950214160603623,0.774055384720096,0.290605993036205,-5.89863360540814,0.0912256458578966,"N4BP1","NEDD4 binding protein 1",TRUE
+"48612_at",0.955645941042265,0.797025514059492,-0.260313938975326,-5.9067322422176,-0.0694008931600631,"N4BP1","NEDD4 binding protein 1",TRUE
+"231996_at",0.0925545494931958,0.00037008501306472,-4.19492736322668,0.220228003222877,-2.57890934547029,"N4BP2","NEDD4 binding protein 2",TRUE
+"228242_at",0.955892698633978,0.799865991533483,-0.256585847368004,-5.90766782423978,-0.145988056917675,"N4BP2","NEDD4 binding protein 2",TRUE
+"229718_at",0.55937703282623,0.0533288738948953,2.04110255553087,-4.09175837289134,0.970103310206225,"N4BP2L1","NEDD4 binding protein 2 like 1",TRUE
+"217197_x_at",0.718706241731185,0.194405368713408,1.33819419062349,-5.10318943074918,0.495477848246307,"N4BP2L1","NEDD4 binding protein 2 like 1",TRUE
+"213375_s_at",0.748760747870936,0.241849778038253,1.20253640190891,-5.2588681561865,1.08942347282214,"N4BP2L1","NEDD4 binding protein 2 like 1",TRUE
+"214906_x_at",0.822173415758858,0.386177236801372,0.884020880907924,-5.56605092450237,0.325491412596605,"N4BP2L1","NEDD4 binding protein 2 like 1",TRUE
+"211390_at",0.841550580403629,0.433056688344373,0.798499620570923,-5.63381314763397,0.416378105592185,"N4BP2L1","NEDD4 binding protein 2 like 1",TRUE
+"214886_s_at",0.893210249171678,0.567782756469349,0.579975526929779,-5.77716402984708,0.350276100412399,"N4BP2L1","NEDD4 binding protein 2 like 1",TRUE
+"214887_at",0.934784679606929,0.710475105880091,0.376024437896177,-5.87104916513636,0.252285917821085,"N4BP2L1","NEDD4 binding protein 2 like 1",TRUE
+"243843_at",0.959357995170594,0.816381895137508,-0.234980554056422,-5.91282559787952,-0.216282375796943,"N4BP2L1","NEDD4 binding protein 2 like 1",TRUE
+"202258_s_at",0.729273475042162,0.211697087949938,1.28606829944448,-5.16468553121704,0.499792186527401,"N4BP2L2","NEDD4 binding protein 2 like 2",TRUE
+"235547_at",0.767727587789514,0.269696863141398,1.13209838890028,-5.33400589602622,0.693003290860945,"N4BP2L2","NEDD4 binding protein 2 like 2",TRUE
+"221899_at",0.780095745457321,0.301472634979805,1.05795918737235,-5.40875052702781,0.514261496456724,"N4BP2L2","NEDD4 binding protein 2 like 2",TRUE
+"1565743_at",0.810375880424165,0.354301946419522,-0.946100238347984,-5.51286825885224,-0.977819472186391,"N4BP2L2","NEDD4 binding protein 2 like 2",TRUE
+"202259_s_at",0.92777930247318,0.683300617326149,0.413381616272236,-5.85679301632969,0.185208015826168,"N4BP2L2","NEDD4 binding protein 2 like 2",TRUE
+"214753_at",0.931370027472813,0.696261505519272,0.395492720733813,-5.86378557451455,0.212402246037737,"N4BP2L2","NEDD4 binding protein 2 like 2",TRUE
+"214748_at",0.932845576227051,0.703810020392174,0.385134678592457,-5.86769513069735,0.23945942347054,"N4BP2L2","NEDD4 binding protein 2 like 2",TRUE
+"215105_at",0.968035667633768,0.849128523914678,-0.192468378568777,-5.92165676639351,-0.149414385304426,"N4BP2L2-IT2","N4BPL2 intronic transcript 2",TRUE
+"214775_at",0.809109571194383,0.352324220757813,-0.950072989458788,-5.50935193772106,-0.535996709117054,"N4BP3","NEDD4 binding protein 3",TRUE
+"234676_s_at",0.652139736047968,0.12127562595115,-1.61127169656544,-4.74858088598036,-1.0967785231602,"N6AMT1","N-6 adenine-specific DNA methyltransferase 1 (putative)",TRUE
+"234698_at",0.856631989847095,0.470584524274681,0.734101834290921,-5.68055690130025,0.233452837410035,"N6AMT1","N-6 adenine-specific DNA methyltransferase 1 (putative)",TRUE
+"220311_at",0.975398143273847,0.881118554538298,0.151286692699571,-5.92854188841739,0.0735566348510615,"N6AMT1","N-6 adenine-specific DNA methyltransferase 1 (putative)",TRUE
+"203025_at",0.69385705848116,0.1633001823086,-1.44196056309296,-4.9747243895985,-0.546875497382032,"NAA10","N(alpha)-acetyltransferase 10, NatA catalytic subunit",TRUE
+"210603_at",0.380731642340006,0.0119009237971976,2.7402053410751,-2.82419097136733,1.9342587867075,"NAA11","N(alpha)-acetyltransferase 11, NatA catalytic subunit",TRUE
+"1556381_at",0.470726957161354,0.0253321678873136,2.39810483147708,-3.47026642450784,1.67905263875464,"NAA15","N(alpha)-acetyltransferase 15, NatA auxiliary subunit",TRUE
+"222836_at",0.585036027492332,0.0653728471302355,1.93875709381148,-4.25803561986525,0.506483855946418,"NAA15","N(alpha)-acetyltransferase 15, NatA auxiliary subunit",TRUE
+"1556382_a_at",0.597654932724127,0.0747551259457819,-1.86999878050285,-4.36643811488208,-1.37596031535355,"NAA15","N(alpha)-acetyltransferase 15, NatA auxiliary subunit",TRUE
+"219158_s_at",0.778974960380281,0.300061084688027,1.06113014006851,-5.40564620735208,0.405543932731108,"NAA15","N(alpha)-acetyltransferase 15, NatA auxiliary subunit",TRUE
+"226998_at",0.90466378569832,0.609015540702434,-0.518840670979578,-5.80941196176771,-0.177024616881063,"NAA15","N(alpha)-acetyltransferase 15, NatA auxiliary subunit",TRUE
+"222837_s_at",0.912722788750542,0.634231564983937,0.482431150211056,-5.82695588359182,0.284934426566537,"NAA15","N(alpha)-acetyltransferase 15, NatA auxiliary subunit",TRUE
+"220656_at",0.778295711796067,0.297904876193475,1.06599450621879,-5.40086787755285,1.06762387858481,"NAA16","N(alpha)-acetyltransferase 16, NatA auxiliary subunit",TRUE
+"219378_at",0.84648993080054,0.444571080016744,-0.778392937261051,-5.64880591116479,-0.247390213163355,"NAA16","N(alpha)-acetyltransferase 16, NatA auxiliary subunit",TRUE
+"1555450_a_at",0.909069952277897,0.622930517135337,-0.498664135828423,-5.81928788739623,-0.193243893195996,"NAA16","N(alpha)-acetyltransferase 16, NatA auxiliary subunit",TRUE
+"223040_at",0.93613089056626,0.714493886013422,-0.370546998165349,-5.87302761875289,-0.141069898217303,"NAA20","N(alpha)-acetyltransferase 20, NatB catalytic subunit",TRUE
+"236816_at",0.627021415091472,0.0976492465463705,1.72938789825061,-4.57935607189754,0.656729851603237,"NAA25","N(alpha)-acetyltransferase 25, NatB auxiliary subunit",TRUE
+"227245_at",0.823073978212882,0.389006863681276,0.878675787847981,-5.57047395649579,0.346764711832208,"NAA25","N(alpha)-acetyltransferase 25, NatB auxiliary subunit",TRUE
+"225888_at",0.930899509890345,0.694390468844031,0.398066930371654,-5.86279810393968,0.11297930288066,"NAA25","N(alpha)-acetyltransferase 25, NatB auxiliary subunit",TRUE
+"225679_at",0.557589172116298,0.0524901422055263,-2.04897342965307,-4.07873529599905,-0.705949086498094,"NAA30","N(alpha)-acetyltransferase 30, NatC catalytic subunit",TRUE
+"231039_at",0.720011171349481,0.195821968321295,-1.3337907752013,-5.1084640480913,-0.55544993146269,"NAA30","N(alpha)-acetyltransferase 30, NatC catalytic subunit",TRUE
+"228322_at",0.952082954955992,0.780808822293572,-0.281672280003849,-5.90111395672401,-0.221031532336125,"NAA30","N(alpha)-acetyltransferase 30, NatC catalytic subunit",TRUE
+"228321_s_at",0.955816406528307,0.798687446783646,0.258132218690697,-5.90728138257552,0.0915758285022159,"NAA30","N(alpha)-acetyltransferase 30, NatC catalytic subunit",TRUE
+"220925_at",0.819479221404744,0.376479095840372,0.902537234999112,-5.55053672232905,0.339855840547722,"NAA35","N(alpha)-acetyltransferase 35, NatC auxiliary subunit",TRUE
+"219362_at",0.990810941805126,0.95568357550774,-0.0562033397639215,-5.93814505534314,-0.0167418562558517,"NAA35","N(alpha)-acetyltransferase 35, NatC auxiliary subunit",TRUE
+"225441_x_at",0.71454754703986,0.189826919094968,-1.35260046684614,-5.08583109211134,-0.551548593780975,"NAA38","N(alpha)-acetyltransferase 38, NatC auxiliary subunit",TRUE
+"224512_s_at",0.860085676417428,0.479474196743141,-0.719300874314736,-5.69077400052743,-0.261335507628209,"NAA38","N(alpha)-acetyltransferase 38, NatC auxiliary subunit",TRUE
+"222369_at",0.657015752622694,0.125987266795345,-1.59007060807599,-4.77798121330455,-0.686727296795688,"NAA40","N(alpha)-acetyltransferase 40, NatD catalytic subunit",TRUE
+"218734_at",0.943988850936011,0.749337104598834,-0.323517501060852,-5.88883389134332,-0.123989221286513,"NAA40","N(alpha)-acetyltransferase 40, NatD catalytic subunit",TRUE
+"239138_at",0.661974206478491,0.129390861888194,1.5751624084142,-4.79847303569515,0.585747565009084,"NAA50","N(alpha)-acetyltransferase 50, NatE catalytic subunit",TRUE
+"222393_s_at",0.857381762624307,0.472812721618858,0.730376658148879,-5.68314700527124,0.226399683140162,"NAA50","N(alpha)-acetyltransferase 50, NatE catalytic subunit",TRUE
+"217745_s_at",0.970023470639887,0.858056060979012,0.180944528423458,-5.92374915493861,0.0605398676783331,"NAA50","N(alpha)-acetyltransferase 50, NatE catalytic subunit",TRUE
+"45526_g_at",0.588984479037728,0.0676684309712384,-1.92117022710492,-4.28602132793092,-0.565952412900169,"NAA60","N(alpha)-acetyltransferase 60, NatF catalytic subunit",TRUE
+"218661_at",0.610033432202476,0.0825640529895122,-1.81830050837359,-4.44611960956955,-0.761163864028422,"NAA60","N(alpha)-acetyltransferase 60, NatF catalytic subunit",TRUE
+"232072_at",0.178066946115198,0.00161212873026105,-3.5911563885208,-1.07745194497758,-2.54623412060944,"NAAA","N-acylethanolamine acid amidase",TRUE
+"214765_s_at",0.662855903464759,0.130715371830036,-1.56944880166706,-4.80628650672575,-0.922745879834324,"NAAA","N-acylethanolamine acid amidase",TRUE
+"227135_at",0.703902004301726,0.175527382792694,-1.39943588681996,-5.02832973487505,-0.805851783498818,"NAAA","N-acylethanolamine acid amidase",TRUE
+"215178_x_at",0.943824539742785,0.748560418036855,-0.32455736759456,-5.88850730728183,-0.143345408323766,"NAAA","N-acylethanolamine acid amidase",TRUE
+"1554506_x_at",0.40150735038542,0.0144153439196448,2.65491514063412,-2.98921433395886,1.79222992407678,"NAALAD2","N-acetylated alpha-linked acidic dipeptidase 2",TRUE
+"1554504_at",0.716749536957327,0.192771869061865,1.34330317608991,-5.09705136461028,1.20794464042057,"NAALAD2","N-acetylated alpha-linked acidic dipeptidase 2",TRUE
+"233815_at",0.749024310703589,0.242153703081786,1.20173575304922,-5.25974445110299,0.641219049121035,"NAALAD2","N-acetylated alpha-linked acidic dipeptidase 2",TRUE
+"1554507_at",0.854464019770416,0.466075545708516,0.741672099682478,-5.67525479776494,0.994999014630766,"NAALAD2","N-acetylated alpha-linked acidic dipeptidase 2",TRUE
+"222161_at",0.899994925762288,0.594055059344137,0.540779529384077,-5.79824060237124,0.417663754457808,"NAALAD2","N-acetylated alpha-linked acidic dipeptidase 2",TRUE
+"228424_at",0.862758430747526,0.486379572216388,0.707913893238852,-5.69849967516355,0.366216290889628,"NAALADL1","N-acetylated alpha-linked acidic dipeptidase-like 1",TRUE
+"207895_at",0.951684340070943,0.778528649859482,-0.284685928052898,-5.90028583687389,-0.117865750235164,"NAALADL1","N-acetylated alpha-linked acidic dipeptidase-like 1",TRUE
+"1557998_at",0.847515494238763,0.446262220878302,-0.775466793091423,-5.65095778317298,-0.515251339766883,"NAALADL2","N-acetylated alpha-linked acidic dipeptidase-like 2",TRUE
+"241587_at",0.722869421140201,0.199294785817457,1.32310027628587,-5.12120876338922,1.20636925336466,"NAALADL2-AS3","NAALADL2 antisense RNA 3",TRUE
+"211139_s_at",0.463632028061434,0.023782020009847,2.42736640012048,-3.4167576169563,1.58879686432056,"NAB1","NGFI-A binding protein 1",TRUE
+"209272_at",0.529974080490865,0.0414479957600172,2.16472860111279,-3.8834950481539,1.97138177968822,"NAB1","NGFI-A binding protein 1",TRUE
+"208047_s_at",0.532405994061663,0.0419239857663515,2.15919456181402,-3.89298354437889,1.80971676166729,"NAB1","NGFI-A binding protein 1",TRUE
+"239875_at",0.812505689959838,0.361163335101819,0.932432224993559,-5.52486265098552,0.47924392962038,"NAB1","NGFI-A binding protein 1",TRUE
+"212803_at",0.829030239823335,0.400159290905741,-0.857851283689114,-5.58746834933923,-0.499800245780714,"NAB2","NGFI-A binding protein 2",TRUE
+"216017_s_at",0.878907265409251,0.532460085509986,-0.634175069764863,-5.74567322118237,-0.702373201093153,"NAB2","NGFI-A binding protein 2",TRUE
+"233085_s_at",0.580152731323135,0.0627840291847638,1.95925561269322,-4.22519592730177,2.26734744814482,"NABP1","nucleic acid binding protein 1",TRUE
+"219334_s_at",0.596382916302699,0.072760698896199,1.88395521185589,-4.34465619333556,1.79268841370467,"NABP1","nucleic acid binding protein 1",TRUE
+"222872_x_at",0.627092759817312,0.0983781619281346,1.72539817232115,-4.58521912533217,2.22955365700042,"NABP1","nucleic acid binding protein 1",TRUE
+"218903_s_at",0.639229300133896,0.109864430422647,-1.66563131560936,-4.67182964071258,-0.755909632935595,"NABP2","nucleic acid binding protein 2",TRUE
+"222018_at",0.68270002258037,0.150548933140766,-1.48913507364467,-4.9137313267925,-0.707107247031353,"NACA","nascent polypeptide-associated complex alpha subunit",TRUE
+"208635_x_at",0.925060113770489,0.67537965165785,-0.424381859720097,-5.85234210353706,-0.0998405082977794,"NACA","nascent polypeptide-associated complex alpha subunit",TRUE
+"200735_x_at",0.93919895813272,0.727904575181505,-0.352350932035624,-5.87939426676161,-0.0804948148572002,"NACA","nascent polypeptide-associated complex alpha subunit",TRUE
+"222224_at",0.945498722604777,0.754228585685564,0.316976845807292,-5.8908642812277,0.116423071833132,"NACA2","nascent polypeptide associated complex alpha subunit 2",TRUE
+"213630_at",0.261028964091316,0.00388619253352229,3.22337345372755,-1.85046805126414,1.77307500248457,"NACAD","NAC alpha domain containing",TRUE
+"211445_x_at",0.94118897722809,0.736730496258148,0.340441832004756,-5.88338967784078,0.0981863989689487,"NACAP1","nascent polypeptide associated complex alpha subunit pseudogene 1",TRUE
+"235047_x_at",0.620912785033482,0.0906912801069124,1.76881247562753,-4.52088189103721,0.859848119588476,"NACC1","nucleus accumbens associated 1",TRUE
+"227651_at",0.839519981963042,0.427774187623153,-0.807834456540007,-5.6267303366869,-0.246192019022303,"NACC1","nucleus accumbens associated 1",TRUE
+"212993_at",0.39149295959037,0.0132732673110494,-2.69175516019582,-2.91823077159227,-1.3193271283744,"NACC2","NACC family member 2",TRUE
+"230050_at",0.928246500493356,0.684847991469324,-0.411238786347242,-5.8576466690904,-0.178219566922021,"NACC2","NACC family member 2",TRUE
+"208917_x_at",0.855662813198157,0.468980037980731,0.736790717858239,-5.6786795565291,0.205917246177808,"NADK","NAD kinase",TRUE
+"215159_s_at",0.892746695408886,0.565751692390117,-0.583043458224921,-5.77545405582867,-0.206423921558395,"NADK","NAD kinase",TRUE
+"213613_s_at",0.899155703544461,0.589429777672628,0.547616488192674,-5.79466726244923,0.303282634257558,"NADK","NAD kinase",TRUE
+"208918_s_at",0.943988850936011,0.74976649665115,0.32294276589824,-5.88901394945985,0.0955757227082543,"NADK","NAD kinase",TRUE
+"213607_x_at",0.953564723226096,0.786084393344286,0.274709835262781,-5.90299371757836,0.0795336207226178,"NADK","NAD kinase",TRUE
+"208919_s_at",0.953983577550391,0.788407347150612,-0.271648526155808,-5.90380544518815,-0.0878575200804956,"NADK","NAD kinase",TRUE
+"226946_at",0.474859593446097,0.0260400911968539,2.38528875719163,-3.49358947193502,0.862884297075659,"NADK2","NAD kinase 2, mitochondrial",TRUE
+"229299_at",0.768852835478002,0.273613197156906,1.12262931818923,-5.34380245572191,0.495677912433758,"NADK2","NAD kinase 2, mitochondrial",TRUE
+"228594_at",0.964645095638491,0.836331773566807,0.209033745514467,-5.91842358665019,0.0890869754701278,"NADK2","NAD kinase 2, mitochondrial",TRUE
+"1563219_at",0.721046612088315,0.197196181382897,1.32954289305346,-5.11353850988796,0.812364599485579,"NADK2-AS1","NADK2 antisense RNA 1",TRUE
+"1565908_at",0.839519981963042,0.428202014374449,-0.80707577862968,-5.62730887034987,-0.499969872846529,"NADSYN1","NAD synthetase 1",TRUE
+"218840_s_at",0.911274533678096,0.629333609824439,0.489450251179925,-5.82367068690939,0.284514409659145,"NADSYN1","NAD synthetase 1",TRUE
+"1565906_at",0.920491425364243,0.66157235471454,0.443685782708741,-5.84425384973718,0.157192884316645,"NADSYN1","NAD synthetase 1",TRUE
+"232946_s_at",0.989524702314661,0.948592235129822,0.0652091887228752,-5.93761258446757,0.0354207130102164,"NADSYN1","NAD synthetase 1",TRUE
+"202268_s_at",0.895213601869362,0.57317079888838,-0.571863913642295,-5.78164311694773,-0.208553710518187,"NAE1","NEDD8 activating enzyme E1 subunit 1",TRUE
+"244828_x_at",0.642957632729672,0.113221693423343,-1.64916364484379,-4.69528663196704,-0.687296552538404,"NAF1","nuclear assembly factor 1 ribonucleoprotein",TRUE
+"210496_at",0.861659105448003,0.482601433248269,0.714132336399847,-5.69429521963085,0.605209005094911,"NAG18","NAG18 mRNA",TRUE
+"202944_at",0.867717011547419,0.500696918103512,0.684597717538156,-5.71395200884402,0.349815672383732,"NAGA","alpha-N-acetylgalactosaminidase",TRUE
+"202943_s_at",0.868397087637799,0.503611496332503,0.679897957267522,-5.71700682181763,0.253789112147425,"NAGA","alpha-N-acetylgalactosaminidase",TRUE
+"1555041_a_at",0.870808709484996,0.51033250680548,0.669118403552952,-5.72393740669752,0.294631130778527,"NAGA","alpha-N-acetylgalactosaminidase",TRUE
+"218231_at",0.99663793883595,0.983278541548749,0.0211966218619622,-5.93946464722316,0.00925931431918414,"NAGK","N-acetylglucosamine kinase",TRUE
+"204360_s_at",0.840872144163754,0.430278068072623,-0.803400925784605,-5.63010392285643,-0.316381018738904,"NAGLU","N-acetyl-alpha-glucosaminidase",TRUE
+"215880_at",0.973433731874338,0.871675602780451,0.163411777717806,-5.92668559801586,0.131080983562038,"NAGLU","N-acetyl-alpha-glucosaminidase",TRUE
+"205090_s_at",0.895213601869362,0.573025443540017,-0.572082233576736,-5.78152336484331,-0.211559162171952,"NAGPA","N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase",TRUE
+"236626_at",0.759576632581869,0.257193272958174,-1.16302327154824,-5.30150688996688,-0.453145443275395,"NAGPA-AS1///ALG1","NAGPA antisense RNA 1///ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase",TRUE
+"229432_at",0.636860247875294,0.107958234487838,1.67517134668389,-4.65815947898149,1.21748361475126,"NAGS","N-acetylglutamate synthase",TRUE
+"1554664_at",0.779477533366902,0.300756434273583,1.05956675960765,-5.40717777674414,0.465486936224065,"NAIF1","nuclear apoptosis inducing factor 1",TRUE
+"227825_at",0.973499570783928,0.872483819067253,0.162373043731481,-5.92685021146924,0.0546537300322054,"NAIF1","nuclear apoptosis inducing factor 1",TRUE
+"204860_s_at",0.686108994812404,0.154678776958412,-1.47351298054669,-4.93410546672156,-1.30556561597198,"NAIP","NLR family apoptosis inhibitory protein",TRUE
+"238446_at",0.971216837324271,0.862828973066447,0.174793927308931,-5.92481322843499,0.0942142058885631,"NAIP","NLR family apoptosis inhibitory protein",TRUE
+"204861_s_at",0.974982245454858,0.87807434102268,-0.155192945672122,-5.92795944215354,-0.0614244126051346,"NAIP","NLR family apoptosis inhibitory protein",TRUE
+"228608_at",0.112518135066489,0.000590064247017215,4.00437505862998,-0.191252675588689,3.285721275202,"NALCN","sodium leak channel, non-selective",TRUE
+"242880_at",0.522667179791589,0.0385018544964117,2.20032008851078,-3.82211214382014,1.67370875759291,"NALCN","sodium leak channel, non-selective",TRUE
+"1554702_at",0.714813484380156,0.190551559850769,1.35030228935485,-5.08861063488043,1.19434916844169,"NALCN","sodium leak channel, non-selective",TRUE
+"232828_at",0.954672574687803,0.793513741583372,-0.264928320405449,-5.90555567515389,-0.0926766170779199,"NALCN-AS1","NALCN antisense RNA 1",TRUE
+"1559765_a_at",0.986342822130003,0.935213404478132,-0.0822156939297154,-5.93639175252036,-0.0248495069023313,"NALT1","NOTCH1 associated lncRNA in T-cell acute lymphoblastic leukemia 1",TRUE
+"217739_s_at",0.629618534694136,0.100439558474664,1.71425002813464,-4.60154818580781,0.942826640704418,"NAMPT","nicotinamide phosphoribosyltransferase",TRUE
+"217738_at",0.638134354959023,0.10949210110893,1.66748367851038,-4.66917998131848,0.919286165402335,"NAMPT","nicotinamide phosphoribosyltransferase",TRUE
+"1555167_s_at",0.728385463227073,0.209820562277978,1.29156144580853,-5.15830252764611,0.74900909193406,"NAMPT","nicotinamide phosphoribosyltransferase",TRUE
+"243296_at",0.760227035076299,0.258067923050217,1.1608243212982,-5.30384317833516,0.710115940167066,"NAMPT","nicotinamide phosphoribosyltransferase",TRUE
+"231079_at",0.636147339487472,0.107632809350778,-1.67681422780165,-4.65579937384079,-1.15379048522524,"NANOG","Nanog homeobox",TRUE
+"220184_at",0.957481612329989,0.808168043486221,0.245710565706559,-5.91032039307207,0.205280490341317,"NANOG","Nanog homeobox",TRUE
+"228526_at",0.866077812635028,0.496827407643096,-0.690861333849462,-5.70984944497081,-0.618418271048361,"NANOS1","nanos C2HC-type zinc finger 1",TRUE
+"228523_at",0.929614487334131,0.689825919209641,-0.404358472796778,-5.8603581099744,-0.313801859169216,"NANOS1","nanos C2HC-type zinc finger 1",TRUE
+"1557767_at",0.782206338814045,0.304184321013934,1.05189707823409,-5.41466204490118,0.507668010946445,"NANOS2","nanos C2HC-type zinc finger 2",TRUE
+"240311_at",0.682381152782224,0.149822279137736,1.49191980420214,-4.91008134714091,0.800473080548871,"NANOS3","nanos C2HC-type zinc finger 3",TRUE
+"228073_at",0.847825099055327,0.447443863433772,-0.773426226339435,-5.65245388031922,-0.398637379311539,"NANP","N-acetylneuraminic acid phosphatase",TRUE
+"241923_x_at",0.630603891142543,0.101566427527808,-1.70823801811071,-4.61032132050282,-0.937725561840458,"NANS","N-acetylneuraminate synthase",TRUE
+"218189_s_at",0.812302873476553,0.357171084282507,-0.940363384949663,-5.51792215664251,-0.454243655589975,"NANS","N-acetylneuraminate synthase",TRUE
+"1556121_at",0.850105705223081,0.452658937286869,0.764459203322759,-5.65898417667121,0.467085038013112,"NAP1L1","nucleosome assembly protein 1 like 1",TRUE
+"212967_x_at",0.860085676417428,0.479004804728662,0.720078354962976,-5.69024222866801,0.293939595977021,"NAP1L1","nucleosome assembly protein 1 like 1",TRUE
+"208752_x_at",0.868361060481977,0.502876359315934,0.681081913333578,-5.71623915401384,0.257643626526923,"NAP1L1","nucleosome assembly protein 1 like 1",TRUE
+"213864_s_at",0.89390639630277,0.569843029404963,0.576869206515591,-5.77888650237293,0.217624283541422,"NAP1L1","nucleosome assembly protein 1 like 1",TRUE
+"208754_s_at",0.939976205834042,0.730324812862629,0.349080129047232,-5.88050511962144,0.18618342064746,"NAP1L1","nucleosome assembly protein 1 like 1",TRUE
+"208753_s_at",0.966313390701604,0.843011449771452,-0.200379753381222,-5.92014580067111,-0.102902704093669,"NAP1L1","nucleosome assembly protein 1 like 1",TRUE
+"204528_s_at",0.976394599691596,0.887603855298974,-0.142972879081983,-5.9297322060137,-0.0543604146060748,"NAP1L1","nucleosome assembly protein 1 like 1",TRUE
+"219368_at",0.801086839730802,0.337447334601107,0.980453836839749,-5.48201635797915,1.41201735020978,"NAP1L2","nucleosome assembly protein 1 like 2",TRUE
+"204749_at",0.78969417320323,0.317754714316645,-1.02212101061501,-5.44325428664086,-1.04252402781125,"NAP1L3","nucleosome assembly protein 1 like 3",TRUE
+"201414_s_at",0.673366993714442,0.139619707551783,-1.53223383360117,-4.85663058912047,-0.548534127523778,"NAP1L4","nucleosome assembly protein 1 like 4",TRUE
+"1560339_s_at",0.729747638370823,0.211979898577653,-1.28524369520837,-5.16564171844124,-0.414072611221435,"NAP1L4","nucleosome assembly protein 1 like 4",TRUE
+"244001_at",0.774230543658252,0.28730251447688,-1.09028703612769,-5.37671275817593,-0.658923272821689,"NAP1L4","nucleosome assembly protein 1 like 4",TRUE
+"236188_s_at",0.986342822130003,0.93450934707866,0.0831113002400502,-5.93631965785185,0.0429731057850922,"NAP1L4","nucleosome assembly protein 1 like 4",TRUE
+"1556567_at",0.989524702314661,0.948647089057918,-0.065139505190791,-5.93761700763305,-0.0336020737151683,"NAP1L4","nucleosome assembly protein 1 like 4",TRUE
+"228063_s_at",0.647754107214051,0.119044086014655,1.62155402073664,-4.73421338854267,2.32928560879515,"NAP1L5","nucleosome assembly protein 1 like 5",TRUE
+"228062_at",0.65862118308879,0.126857607299644,1.58622683829428,-4.78327903209245,2.10712847872778,"NAP1L5","nucleosome assembly protein 1 like 5",TRUE
+"208751_at",0.199384790683032,0.00220991647286543,-3.46018164799912,-1.35501432404212,-1.23296430668442,"NAPA","NSF attachment protein alpha",TRUE
+"206491_s_at",0.257126595624443,0.00378127060926752,-3.23493999487001,-1.82649417174823,-1.24848938234055,"NAPA","NSF attachment protein alpha",TRUE
+"235934_at",0.855700428029382,0.469029915363902,0.736707048888968,-5.67873807133749,0.246312003949843,"NAPA-AS1","NAPA antisense RNA 1",TRUE
+"239362_at",0.88483731736619,0.544965922724995,-0.614774791092276,-5.75725672810907,-0.336815027143347,"NAPA-AS1","NAPA antisense RNA 1",TRUE
+"1570441_at",0.84932977991296,0.450334913005775,0.768447460093917,-5.65608858163961,0.716806950315101,"NAPB","NSF attachment protein beta",TRUE
+"225111_s_at",0.956762870061999,0.80424425416725,-0.250846681456388,-5.90908187999292,-0.160435789346125,"NAPB","NSF attachment protein beta",TRUE
+"238722_x_at",0.518839312292606,0.0372178835447938,2.21661053607656,-3.7938121772518,0.589011627134509,"NAPEPLD","N-acyl phosphatidylethanolamine phospholipase D",TRUE
+"242229_at",0.662855903464759,0.130589613660285,1.56998922314129,-4.80554842335296,0.528018483046207,"NAPEPLD","N-acyl phosphatidylethanolamine phospholipase D",TRUE
+"242635_s_at",0.695744345349551,0.165327968223589,1.43473528545772,-4.98392504808946,0.566565783581138,"NAPEPLD","N-acyl phosphatidylethanolamine phospholipase D",TRUE
+"233539_at",0.757950630724418,0.254139548088352,1.17074440075481,-5.29327285099896,0.53823328715183,"NAPEPLD","N-acyl phosphatidylethanolamine phospholipase D",TRUE
+"226041_at",0.942684843065067,0.743065587019356,0.331924633148747,-5.88616381277978,0.122459832808241,"NAPEPLD","N-acyl phosphatidylethanolamine phospholipase D",TRUE
+"210048_at",0.686108994812404,0.154693034998743,1.47345963646819,-4.93417474023419,0.509705983260737,"NAPG","NSF attachment protein gamma",TRUE
+"225448_at",0.899094059893116,0.589331266550696,0.547762390835114,-5.79459053100413,0.25971516786425,"NAPG","NSF attachment protein gamma",TRUE
+"226708_at",0.694519360341564,0.164037265510279,1.43932592294872,-4.97808370801517,0.410983130553713,"NAPRT","nicotinate phosphoribosyltransferase",TRUE
+"226707_at",0.773234064853267,0.284492629946455,1.09683304606603,-5.37012078869329,1.03101097187703,"NAPRT","nicotinate phosphoribosyltransferase",TRUE
+"223806_s_at",0.760463372361683,0.259478826296009,1.15728879170765,-5.30759139129554,0.317287767430908,"NAPSA","napsin A aspartic peptidase",TRUE
+"228055_at",0.917166618334994,0.649795987838512,0.460286423453519,-5.83701606186111,0.359777196725956,"NAPSB","napsin B aspartic peptidase, pseudogene",TRUE
+"228056_s_at",0.968269082055813,0.850890520844523,-0.190191893423126,-5.92208030961487,-0.0802860553890503,"NAPSB","napsin B aspartic peptidase, pseudogene",TRUE
+"219862_s_at",0.946119745055175,0.75595278048212,0.314674708433433,-5.89156915361471,0.114471126556012,"NARF","nuclear prelamin A recognition factor",TRUE
+"237299_at",0.996118448346386,0.980516045293366,-0.0246991364337374,-5.93938635354991,-0.0183173749228063,"NARF","nuclear prelamin A recognition factor",TRUE
+"218742_at",0.703896906014433,0.175338873048078,-1.40007324057652,-5.02753605369081,-0.565120099571006,"NARFL","nuclear prelamin A recognition factor like",TRUE
+"1555630_a_at",0.541849190341655,0.0452793094007595,2.12171986861132,-3.95683470827343,3.65215379594767,"NARR///RAB34","nine-amino acid residue-repeats///RAB34, member RAS oncogene family",TRUE
+"224710_at",0.567651250567208,0.0577578012176139,2.00128422686012,-4.1571322013708,4.62573289620502,"NARR///RAB34","nine-amino acid residue-repeats///RAB34, member RAS oncogene family",TRUE
+"200027_at",0.564004192185035,0.0558369769980047,-2.01820744157493,-4.129452165616,-0.571223293425582,"NARS","asparaginyl-tRNA synthetase",TRUE
+"219217_at",0.889564089063817,0.557764807098492,-0.59516304226548,-5.76861364633734,-0.228765289718016,"NARS2","asparaginyl-tRNA synthetase 2, mitochondrial (putative)",TRUE
+"242918_at",0.951893068371814,0.779643318476941,0.283212363218924,-5.90069185011795,0.147405583130754,"NASP","nuclear autoantigenic sperm protein",TRUE
+"201969_at",0.956820331597905,0.804432783963971,-0.250599745275474,-5.90914200849811,-0.0953974816527001,"NASP","nuclear autoantigenic sperm protein",TRUE
+"201970_s_at",0.998384473324293,0.993417658934824,0.00834342100097392,-5.93964957503906,0.00354027889463104,"NASP","nuclear autoantigenic sperm protein",TRUE
+"214440_at",0.660054711393139,0.127942517860148,-1.58146603164721,-4.78982690735516,-1.30425944079083,"NAT1","N-acetyltransferase 1",TRUE
+"217884_at",0.940227139261806,0.73286824293927,-0.345647016426749,-5.88166008296366,-0.15470109349511,"NAT10","N-acetyltransferase 10",TRUE
+"223284_at",0.87548954903345,0.522891837653174,-0.649185114627176,-5.73647359833384,-0.280506877563914,"NAT14","N-acetyltransferase 14 (putative)",TRUE
+"240784_at",0.580137756009815,0.0626855935164139,1.96004966104422,-4.22391907571809,1.21552071023675,"NAT16","N-acetyltransferase 16 (putative)",TRUE
+"1564658_at",0.65284137151906,0.122232314777011,1.60691192615349,-4.75465143211852,0.542426988919455,"NAT16","N-acetyltransferase 16 (putative)",TRUE
+"206797_at",0.660068911122272,0.128012829817536,-1.58115864786224,-4.79024914537621,-1.03358954212884,"NAT2","N-acetyltransferase 2",TRUE
+"210874_s_at",0.943988850936011,0.749292204055956,-0.323577606216568,-5.88881504276219,-0.275590618649938,"NAT6","N-acetyltransferase 6",TRUE
+"206964_at",0.942961933269639,0.744189903873303,-0.330415678949687,-5.88664804319076,-0.225342062679258,"NAT8B","N-acetyltransferase 8B (putative, gene/pseudogene)",TRUE
+"210289_at",0.623503825356688,0.0940972139862517,-1.74920207342844,-4.55008957192439,-1.11037915010574,"NAT8B///NAT8","N-acetyltransferase 8B (putative, gene/pseudogene)///N-acetyltransferase 8 (putative)",TRUE
+"206963_s_at",0.866807918403275,0.498269670609233,0.688523497962546,-5.71138486320765,0.516872503634024,"NAT8B///NAT8","N-acetyltransferase 8B (putative, gene/pseudogene)///N-acetyltransferase 8 (putative)",TRUE
+"228880_at",0.795600080092948,0.327752132802342,-1.00075058036641,-5.46331756180913,-0.513283020667007,"NAT8L","N-acetyltransferase 8 like",TRUE
+"235316_at",0.995710500788917,0.979454112254952,0.0260456222239878,-5.93935307497372,0.0219729070094674,"NAT8L","N-acetyltransferase 8 like",TRUE
+"204382_at",0.936992192746977,0.718016465534482,-0.365755344649987,-5.87473487121625,-0.1455632451428,"NAT9","N-acetyltransferase 9 (putative)",TRUE
+"226657_at",0.7974001826642,0.330699780159178,0.994536354652139,-5.46907953018123,0.440028796381709,"NATD1","N-acetyltransferase domain containing 1",TRUE
+"1553872_at",0.888505957655133,0.554635726287512,-0.599935748087015,-5.76588256044518,-0.167569693665443,"NATD1","N-acetyltransferase domain containing 1",TRUE
+"233870_at",0.843475287501313,0.43860478767116,0.788770943146155,-5.64111239418388,0.478347579457011,"NAV1","neuron navigator 1",TRUE
+"242986_at",0.884757591377679,0.544336010573009,-0.615746246600788,-5.75668493854574,-0.462673252255864,"NAV1","neuron navigator 1",TRUE
+"224772_at",0.94895689004559,0.769155189396654,0.297103273129874,-5.89678146065258,0.307254309747697,"NAV1","neuron navigator 1",TRUE
+"224771_at",0.964843159353411,0.837238570687942,-0.207857982440019,-5.91866182938494,-0.231379667533075,"NAV1","neuron navigator 1",TRUE
+"224774_s_at",0.969859842767097,0.855933318710812,0.183682277177588,-5.92326371877389,0.23907748595192,"NAV1","neuron navigator 1",TRUE
+"224773_at",0.971867994936839,0.865298870263059,-0.17161382345161,-5.9253490084834,-0.226899523166669,"NAV1","neuron navigator 1",TRUE
+"224770_s_at",0.979588787486838,0.902565884078411,0.123830631565071,-5.93221760108261,0.071521408177432,"NAV1","neuron navigator 1",TRUE
+"227584_at",0.990810941805126,0.956255615442628,0.0554770791851358,-5.93818455465165,0.0451232718112227,"NAV1","neuron navigator 1",TRUE
+"222599_s_at",0.634202341398092,0.105182485928798,1.68932136947768,-4.63777469458619,1.08558796072749,"NAV2","neuron navigator 2",TRUE
+"1567358_at",0.66927199146331,0.135342816334216,-1.54985629495737,-4.83290998851666,-0.864743366199835,"NAV2","neuron navigator 2",TRUE
+"222598_s_at",0.75959865506602,0.257342943813254,1.16264659253901,-5.30190737009051,0.506110452721615,"NAV2","neuron navigator 2",TRUE
+"218330_s_at",0.769847953580141,0.277570033642677,1.11316234957326,-5.3535240356695,1.28009670067376,"NAV2","neuron navigator 2",TRUE
+"1567357_at",0.822600785740588,0.387627291270792,-0.88127858899818,-5.56832326223681,-0.644224321220349,"NAV2","neuron navigator 2",TRUE
+"1556606_at",0.97897951922649,0.898138388083315,0.129489855051566,-5.93151988851927,0.103673706135975,"NAV2","neuron navigator 2",TRUE
+"237512_at",0.55679801038721,0.0520884128001702,2.05278321608018,-4.07241984684577,0.995404027651396,"NAV2-AS2","NAV2 antisense RNA 2",TRUE
+"233077_at",0.819018525257656,0.373586298857978,-0.908121033156693,-5.5457999132445,-0.386309544378142,"NAV2-AS4","NAV2 antisense RNA 4",TRUE
+"1562320_at",0.769847953580141,0.278316770391333,1.11138678297284,-5.35533923051024,0.286325240268492,"NAV2-AS5","NAV2 antisense RNA 5",TRUE
+"1561050_a_at",0.711989638658417,0.186056458871681,1.36467119588218,-5.07116727263155,0.637716481060029,"NAV2-IT1","NAV2 intronic transcript 1",TRUE
+"204823_at",0.678126513742682,0.145350687529654,1.50930295877909,-4.88717340974218,1.62550524872024,"NAV3","neuron navigator 3",TRUE
+"216632_at",0.698391916012681,0.169629204969593,1.41964210959254,-5.00302259787055,0.612653567251366,"NAV3","neuron navigator 3",TRUE
+"216466_at",0.820611742812032,0.380939944150556,0.893981879961393,-5.55774194434517,0.8907163820979,"NAV3","neuron navigator 3",TRUE
+"1552658_a_at",0.889725783121438,0.557935769549184,0.59490268001566,-5.7687620271862,0.407574456620965,"NAV3","neuron navigator 3",TRUE
+"1562234_a_at",0.993083193605528,0.967217542980047,0.0415652779789481,-5.93884203028812,0.0356475583264495,"NAV3","neuron navigator 3",TRUE
+"217940_s_at",0.839519981963042,0.426585709319038,0.809944502305624,-5.62511862771637,0.332791003460001,"NAXD","NAD(P)HX dehydratase",TRUE
+"225427_s_at",0.768852835478002,0.272874613375587,-1.124407473968,-5.34196834950854,-0.355265570126052,"NAXE","NAD(P)HX epimerase",TRUE
+"202926_at",0.60034471552122,0.0765542452055591,-1.85768511456944,-4.38556111272936,-0.459270496276472,"NBAS","neuroblastoma amplified sequence",TRUE
+"242049_s_at",0.806089660856733,0.346526408573876,0.961807086386615,-5.49888722128408,0.584168644430115,"NBAS","neuroblastoma amplified sequence",TRUE
+"240579_at",0.932830928398943,0.703576235837105,-0.385454828083573,-5.86757582438517,-0.384212875450594,"NBAS","neuroblastoma amplified sequence",TRUE
+"241670_x_at",0.75710709622615,0.25285413929023,1.17401510015466,-5.28977050341066,0.753760126469216,"NBAT1","neuroblastoma associated transcript 1",TRUE
+"221207_s_at",0.7974001826642,0.330613105771557,-0.994718533152234,-5.46891107400756,-0.547669955618406,"NBEA","neurobeachin",TRUE
+"226439_s_at",0.835973067952943,0.417232599192922,-0.826679927949093,-5.61219608974936,-0.392697303994368,"NBEA","neurobeachin",TRUE
+"1561589_a_at",0.76150249762201,0.260606618666824,1.1544729181737,-5.31056947583406,0.871709391505044,"NBEAL1","neurobeachin like 1",TRUE
+"1554106_at",0.915409740314202,0.643409286892742,-0.469344407517874,-5.83295700669833,-0.18241173737897,"NBEAL1","neurobeachin like 1",TRUE
+"200088_x_at",0.911028479628096,0.628838103160669,0.490161730628369,-5.82333509989071,0.130769292951255,"NBEAL1///RPL12","neurobeachin like 1///ribosomal protein L12",TRUE
+"212443_at",0.932830928398943,0.703258552792302,-0.385889935685152,-5.86741352134126,-0.175601555206985,"NBEAL2","neurobeachin like 2",TRUE
+"1556017_at",0.943988850936011,0.748979325203745,0.32399646860473,-5.88868359402831,0.201356825879198,"NBEAL2","neurobeachin like 2",TRUE
+"1560683_at",0.382348164866486,0.0120589514701708,2.73436441926844,-2.83556831481126,3.23230922679989,"NBEAP1","neurobeachin pseudogene 1",TRUE
+"1560684_x_at",0.384586587899771,0.0125237048812575,2.71759695269796,-2.86816811929251,2.06930799007823,"NBEAP1","neurobeachin pseudogene 1",TRUE
+"201621_at",0.790657561917617,0.320360831667888,1.01650549950031,-5.44856347777599,1.3281328928086,"NBL1","neuroblastoma 1, DAN family BMP antagonist",TRUE
+"240510_at",0.598189234863253,0.0754260006428398,-1.86537721844432,-4.37362583422398,-1.15735659514038,"NBN","nibrin",TRUE
+"217299_s_at",0.925511384407886,0.677831807480656,-0.420970798102219,-5.85373457745155,-0.236562234651608,"NBN","nibrin",TRUE
+"202905_x_at",0.932830928398943,0.703781907571219,-0.38517317471293,-5.86768078997384,-0.18198052777722,"NBN","nibrin",TRUE
+"202907_s_at",0.954627246077849,0.79328121761005,-0.265234057534548,-5.90547699347112,-0.0907666019154618,"NBN","nibrin",TRUE
+"202906_s_at",0.986342822130003,0.93500176615117,-0.0824849042211806,-5.93637016363826,-0.04482341725274,"NBN","nibrin",TRUE
+"212854_x_at",0.857110337466729,0.471759790060997,-0.732135692872905,-5.68192551266347,-0.216122696311489,"NBPF1","neuroblastoma breakpoint family member 1",TRUE
+"236273_at",0.928819762424586,0.686706561618455,0.40866759237076,-5.85866521086895,0.226489352733992,"NBPF1","neuroblastoma breakpoint family member 1",TRUE
+"229447_x_at",0.884343471732163,0.54348102411838,-0.617065769631374,-5.75590688581766,-0.167353382442025,"NBPF10///NBPF8///NBPF11","neuroblastoma breakpoint family member 10///neuroblastoma breakpoint family member 8///neuroblastoma breakpoint family member 11",TRUE
+"227926_s_at",0.745001525353357,0.236751742167619,-1.21608081874473,-5.24396733770083,-0.636272680313532,"NBPF20","neuroblastoma breakpoint family member 20",TRUE
+"227927_at",0.826515565081325,0.394686692065996,-0.8680225149244,-5.57921518147875,-0.388628151026472,"NBPF20","neuroblastoma breakpoint family member 20",TRUE
+"201103_x_at",0.85492369444809,0.467028328344766,-0.740068841287035,-5.67638200321093,-0.200814531775666,"NBPF20///NBPF10///NBPF8///NBPF9///NBPF15///NBPF11///NBPF12///NBPF14","neuroblastoma breakpoint family member 20///neuroblastoma breakpoint family member 10///neuroblastoma breakpoint family member 8///neuroblastoma breakpoint family member 9///neuroblastoma breakpoint family member 15///neuroblastoma breakpoint family member 11///neuroblastoma breakpoint family member 12///neuroblastoma breakpoint family member 14",TRUE
+"213612_x_at",0.899808883319249,0.592266895495298,-0.543419633530278,-5.79686592153276,-0.149532795722877,"NBPF20///NBPF10///NBPF8///NBPF9///NBPF15///NBPF12///NBPF14","neuroblastoma breakpoint family member 20///neuroblastoma breakpoint family member 10///neuroblastoma breakpoint family member 8///neuroblastoma breakpoint family member 9///neuroblastoma breakpoint family member 15///neuroblastoma breakpoint family member 12///neuroblastoma breakpoint family member 14",TRUE
+"201104_x_at",0.677013732819214,0.144206662335436,-1.51382046700409,-4.88118536451419,-0.483129304479499,"NBPF25P///NBPF26///NBPF19///NBPF20///NBPF10///NBPF8///NBPF9///NBPF15///NBPF11///NBPF14","neuroblastoma breakpoint family member 25, pseudogene///neuroblastoma breakpoint family member 26///neuroblastoma breakpoint family member 19///neuroblastoma breakpoint family member 20///neuroblastoma breakpoint family member 10///neuroblastoma breakpoint family member 8///neuroblastoma breakpoint family member 9///neuroblastoma breakpoint family member 15///neuroblastoma breakpoint family member 11///neuroblastoma breakpoint family member 14",TRUE
+"226740_x_at",0.870517518639056,0.509427663671802,-0.670564985967638,-5.72301350309074,-0.18068536804088,"NBPF26///NBPF10///NBPF14","neuroblastoma breakpoint family member 26///neuroblastoma breakpoint family member 10///neuroblastoma breakpoint family member 14",TRUE
+"214693_x_at",0.965992617204023,0.841115876126784,0.202833983008228,-5.91966475572309,0.0748917860675782,"NBPF26///NBPF10///NBPF9///NBPF14","neuroblastoma breakpoint family member 26///neuroblastoma breakpoint family member 10///neuroblastoma breakpoint family member 9///neuroblastoma breakpoint family member 14",TRUE
+"223638_at",0.820442898002464,0.37948414100934,-0.896766652619041,-5.55540360836087,-0.427067125781324,"NBPF3","neuroblastoma breakpoint family member 3",TRUE
+"1558825_s_at",0.909441642299191,0.623853750481862,0.497332943017653,-5.81992603341187,0.304297281818184,"NBPF3","neuroblastoma breakpoint family member 3",TRUE
+"1553910_at",0.829763528801337,0.401200341058841,0.85592656667985,-5.5890199184424,0.94091941510636,"NBPF4","neuroblastoma breakpoint family member 4",TRUE
+"237917_at",0.739189560382301,0.226198852313514,-1.24483459777468,-5.21185623116762,-0.463912544591736,"NBPF8","neuroblastoma breakpoint family member 8",TRUE
+"1568856_at",0.61760967235709,0.0879759791596148,1.78490508429428,-4.49673533094739,1.140995255689,"NBR1","NBR1, autophagy cargo receptor",TRUE
+"201384_s_at",0.958931830316768,0.814096731007104,-0.237962849994785,-5.9121404631563,-0.0733887401632956,"NBR1","NBR1, autophagy cargo receptor",TRUE
+"1568857_a_at",0.982243328340126,0.91444720569976,-0.108663849414916,-5.93393395703419,-0.0781275881475771,"NBR1","NBR1, autophagy cargo receptor",TRUE
+"201383_s_at",0.986342822130003,0.935473721584831,0.0818845713080111,-5.9364182096355,0.0245919705533044,"NBR1","NBR1, autophagy cargo receptor",TRUE
+"1553992_s_at",0.885029460971826,0.546042246794462,-0.613116253533239,-5.75823091594278,-0.33885159905088,"NBR2","neighbor of BRCA1 gene 2 (non-protein coding)",TRUE
+"207631_at",0.955892698633978,0.799481651129832,-0.257090070874173,-5.90754207115631,-0.196577183111627,"NBR2","neighbor of BRCA1 gene 2 (non-protein coding)",TRUE
+"1562790_at",0.827866702343255,0.397107847433519,0.863511477857274,-5.58288670798568,0.605424241652134,"NCALD","neurocalcin delta",TRUE
+"211685_s_at",0.954456115752166,0.791407863070366,-0.267698207119971,-5.90483955211239,-0.169388354040335,"NCALD","neurocalcin delta",TRUE
+"229799_s_at",0.690381347688918,0.160042590314652,-1.45372066242991,-4.95966856091723,-1.04889478253208,"NCAM1","neural cell adhesion molecule 1",TRUE
+"217359_s_at",0.700466202059297,0.172223305280341,1.41068704769856,-5.01427514801156,0.510531766722926,"NCAM1","neural cell adhesion molecule 1",TRUE
+"227394_at",0.776936981479994,0.295238588300183,1.07204449763702,-5.39489759585618,0.343053884256825,"NCAM1","neural cell adhesion molecule 1",TRUE
+"231532_at",0.869684594766105,0.507175314026176,0.674172102470482,-5.72070138962637,0.545380689043208,"NCAM1","neural cell adhesion molecule 1",TRUE
+"209968_s_at",0.898098183774511,0.587033978390111,-0.551168274234289,-5.7927937067753,-0.393469577893502,"NCAM1","neural cell adhesion molecule 1",TRUE
+"214952_at",0.956938436670832,0.80464251578004,-0.250325057416789,-5.90920882532816,-0.169476227920541,"NCAM1","neural cell adhesion molecule 1",TRUE
+"212843_at",0.978951900396372,0.897634802737372,-0.130133808494706,-5.93143852468893,-0.101797889200853,"NCAM1","neural cell adhesion molecule 1",TRUE
+"205669_at",0.369429132228615,0.0110066816542345,-2.77471007649516,-2.75676003764396,-2.38401063637392,"NCAM2","neural cell adhesion molecule 2",TRUE
+"232390_at",0.67571432533675,0.142335654044872,-1.52127235715815,-4.87127653059388,-2.16982960803412,"NCAM2","neural cell adhesion molecule 2",TRUE
+"234527_at",0.993753494258002,0.970482436827763,-0.0374235470383987,-5.93900136120389,-0.0220218362958295,"NCAM2","neural cell adhesion molecule 2",TRUE
+"205143_at",0.972405051071295,0.866977657287566,0.169453345205128,-5.92570740738056,0.158482439954629,"NCAN","neurocan",TRUE
+"201774_s_at",0.627168487417459,0.098970456505493,1.72217477569321,-4.58994865936875,0.796976207274916,"NCAPD2","non-SMC condensin I complex subunit D2",TRUE
+"212789_at",0.920835753388243,0.663437901002133,-0.4410677041281,-5.84537151215008,-0.183199667929582,"NCAPD3","non-SMC condensin II complex subunit D3",TRUE
+"218662_s_at",0.782198428867091,0.30398782694671,1.05233505731853,-5.4142359679522,0.512524572603821,"NCAPG","non-SMC condensin I complex subunit G",TRUE
+"218663_at",0.805335305758344,0.344614126367919,0.965706569929081,-5.49538357727896,0.440205918194192,"NCAPG","non-SMC condensin I complex subunit G",TRUE
+"219588_s_at",0.89967769475675,0.590979573892528,-0.54532269804348,-5.79587097586268,-0.179009249704718,"NCAPG2","non-SMC condensin II complex subunit G2",TRUE
+"212949_at",0.622917527985155,0.0937851846915871,1.75097308712059,-4.5474616886177,0.736393694095691,"NCAPH","non-SMC condensin I complex subunit H",TRUE
+"40640_at",0.693850056112024,0.163130233301894,1.44256938971281,-4.97394738754341,0.490713416842676,"NCAPH2","non-SMC condensin II complex subunit H2",TRUE
+"209718_at",0.864894115958506,0.493180301080034,0.696790432700459,-5.70593311806247,0.403316609969304,"NCAPH2","non-SMC condensin II complex subunit H2",TRUE
+"227076_at",0.875187315707138,0.522219536292286,-0.650245399963976,-5.7358159359864,-0.344181318487953,"NCAPH2","non-SMC condensin II complex subunit H2",TRUE
+"205086_s_at",0.897949253801113,0.586412620727356,-0.55209061057487,-5.79230525342952,-0.276154464777988,"NCAPH2","non-SMC condensin II complex subunit H2",TRUE
+"221633_at",0.931370027472813,0.696663537935032,-0.394939951915894,-5.863996794435,-0.154384182924221,"NCAPH2","non-SMC condensin II complex subunit H2",TRUE
+"209519_at",0.895195476627048,0.572777747761208,0.57245433088393,-5.7813191612377,0.260142342910455,"NCBP1","nuclear cap binding protein subunit 1",TRUE
+"209520_s_at",0.992556028381381,0.965227699460028,-0.0440898851214145,-5.9387367143302,-0.0172771474460074,"NCBP1","nuclear cap binding protein subunit 1",TRUE
+"201517_at",0.837368340567858,0.420377684497506,0.821026446044074,-5.61658921805658,0.27800567744052,"NCBP2","nuclear cap binding protein subunit 2",TRUE
+"201521_s_at",0.90344422113846,0.604340809943413,0.525667793433855,-5.80598382528395,0.248684509052936,"NCBP2","nuclear cap binding protein subunit 2",TRUE
+"225657_at",0.694519360341564,0.164037561938778,-1.43932486531023,-4.97808505555848,-0.683461415643876,"NCBP2-AS2","NCBP2 antisense RNA 2 (head to head)",TRUE
+"229342_at",0.585541754681483,0.0657777312712148,1.93561613161885,-4.26304666979281,0.537712307170681,"NCBP3","nuclear cap binding subunit 3",TRUE
+"218896_s_at",0.648928057811151,0.119720847172219,1.61841877158906,-4.73860175960433,0.480234572548845,"NCBP3","nuclear cap binding subunit 3",TRUE
+"222779_s_at",0.697172073261335,0.167502982459984,1.42706420331911,-4.99365202293859,0.504825503744943,"NCBP3","nuclear cap binding subunit 3",TRUE
+"236384_at",0.723655063748891,0.200586062942051,1.31916240391528,-5.12588153036233,0.365745910858063,"NCBP3","nuclear cap binding subunit 3",TRUE
+"228983_at",0.94960065125426,0.77211015483084,0.293183673066842,-5.89790366007561,0.113760399563914,"NCBP3","nuclear cap binding subunit 3",TRUE
+"209556_at",0.653593944884398,0.122968614245155,-1.60357586738396,-4.75928794569396,-0.603209343434269,"NCDN","neurochondrin",TRUE
+"209557_s_at",0.851319596585235,0.454664520194469,-0.761027351104014,-5.66146440617303,-0.49444552163533,"NCDN","neurochondrin",TRUE
+"237002_at",0.932091525948902,0.70026095494634,-0.389999279916993,-5.86587176037262,-0.226474479553457,"NCDN","neurochondrin",TRUE
+"225847_at",0.470726957161354,0.0253603578863591,2.39758819594256,-3.47120795229732,1.59470453813238,"NCEH1","neutral cholesterol ester hydrolase 1",TRUE
+"214084_x_at",0.217184829141687,0.00261376529630051,3.39012552180212,-1.50253023706459,1.3912690490328,"NCF1","neutrophil cytosolic factor 1",TRUE
+"204961_s_at",0.661974206478491,0.129387640446527,1.57517636394012,-4.79845392398827,0.703127502249258,"NCF1C///NCF1B///NCF1","neutrophil cytosolic factor 1C pseudogene///neutrophil cytosolic factor 1B pseudogene///neutrophil cytosolic factor 1",TRUE
+"209949_at",0.0831266833622311,0.00030711641589704,4.27101923175527,0.384664606196364,4.40565825345367,"NCF2","neutrophil cytosolic factor 2",TRUE
+"205147_x_at",0.751112081216662,0.244118663582714,-1.19657747608745,-5.26537792353797,-0.662083117738845,"NCF4","neutrophil cytosolic factor 4",TRUE
+"207677_s_at",0.796630089799502,0.329465234788339,-0.99713433393549,-5.46667459011371,-0.673774953103464,"NCF4","neutrophil cytosolic factor 4",TRUE
+"204725_s_at",0.69805586360447,0.169062627387562,1.42161256170506,-5.00053876192339,0.410075323903984,"NCK1","NCK adaptor protein 1",TRUE
+"244487_at",0.789795896476304,0.318365289608993,1.02080249574789,-5.44450325309467,0.43483866339515,"NCK1","NCK adaptor protein 1",TRUE
+"236922_at",0.848268984089208,0.447968733760477,0.772520883619201,-5.653116465561,0.336053698246166,"NCK1","NCK adaptor protein 1",TRUE
+"211063_s_at",0.871451481476429,0.512757563233571,0.665248490582367,-5.72639964858209,0.214849951239986,"NCK1","NCK adaptor protein 1",TRUE
+"228799_at",0.979588787486838,0.901936751307491,-0.124634531996068,-5.93212038680401,-0.0529066261778883,"NCK1-AS1","NCK1 antisense RNA 1 (head to head)",TRUE
+"203315_at",0.92904199996892,0.687193718568689,-0.407994110867984,-5.85893096206467,-0.151458124482435,"NCK2","NCK adaptor protein 2",TRUE
+"217465_at",0.838638505907806,0.423836473621299,0.814839633438081,-5.62136440682523,0.394057364981027,"NCKAP1","NCK associated protein 1",TRUE
+"207738_s_at",0.888232641270866,0.554049804365172,0.600831000665423,-5.7653679231795,0.203695675458132,"NCKAP1","NCK associated protein 1",TRUE
+"209734_at",0.820293495506061,0.379369300137963,-0.896986627590074,-5.55521861162381,-0.370374173300945,"NCKAP1L","NCK associated protein 1 like",TRUE
+"217549_at",0.83364851657447,0.411213880769673,0.837574349312259,-5.60365087901491,0.394049773750957,"NCKAP1L","NCK associated protein 1 like",TRUE
+"238668_at",0.855395723404557,0.467940517774168,0.738535705435524,-5.67745774351116,0.239355575725329,"NCKAP1L","NCK associated protein 1 like",TRUE
+"239650_at",0.914777625972484,0.641175599653789,-0.472521740893616,-5.83151483656883,-0.809754754248512,"NCKAP5","NCK associated protein 5",TRUE
+"231865_at",0.721907781985393,0.198144715312632,-1.32662433478745,-5.11701708506071,-0.460124690578364,"NCKAP5L","NCK associated protein 5 like",TRUE
+"1562457_at",0.955316686567461,0.795449553744972,-0.262383991145963,-5.90620696373932,-0.242227154720722,"NCKAP5L","NCK associated protein 5 like",TRUE
+"216114_at",0.676468346171966,0.143232780286343,1.51768930684239,-4.87604578364303,0.997216896722828,"NCKIPSD","NCK interacting protein with SH3 domain",TRUE
+"218697_at",0.725583196024696,0.204485819670484,-1.30738845389146,-5.13978257911497,-0.403453047461197,"NCKIPSD","NCK interacting protein with SH3 domain",TRUE
+"233165_at",0.806216644294069,0.346712663061349,0.961428064211853,-5.49922707768779,0.675395371970801,"NCKIPSD","NCK interacting protein with SH3 domain",TRUE
+"241892_at",0.961212424803935,0.823712784987493,0.225427784075624,-5.91496232580225,0.0632915509627239,"NCL","nucleolin",TRUE
+"200610_s_at",0.977254232093199,0.891283251074276,0.138260709834662,-5.93037705716696,0.0365168861941925,"NCL","nucleolin",TRUE
+"215859_at",0.632977954834093,0.104309673032559,1.69383614432952,-4.63124338992963,1.04410970331276,"NCLN","nicalin",TRUE
+"215857_at",0.93342602828701,0.705477160803002,-0.382852846797356,-5.86854264317552,-0.200063095995148,"NCLN","nicalin",TRUE
+"222206_s_at",0.948429371744093,0.765751009557411,0.301624633313209,-5.89546862198401,0.152816868122256,"NCLN","nicalin",TRUE
+"209105_at",0.615637099066718,0.0860535206983754,-1.79655953828256,-4.47914858912261,-0.838855909202701,"NCOA1","nuclear receptor coactivator 1",TRUE
+"209106_at",0.671298718565642,0.137192263424718,-1.54218034001068,-4.84326855985671,-0.778497610690708,"NCOA1","nuclear receptor coactivator 1",TRUE
+"209107_x_at",0.732088067718098,0.215808306829383,-1.27416367382757,-5.17843909408583,-0.531365187396474,"NCOA1","nuclear receptor coactivator 1",TRUE
+"210249_s_at",0.831875452294783,0.407234221399808,-0.844833522581693,-5.5978990107586,-0.315597996340406,"NCOA1","nuclear receptor coactivator 1",TRUE
+"212867_at",0.774230543658252,0.287109309189488,-1.09073565077308,-5.37626211540252,-0.594454731313261,"NCOA2","nuclear receptor coactivator 2",TRUE
+"205732_s_at",0.777893343238007,0.296986660205764,-1.06807361561949,-5.3988195712686,-0.568276542259962,"NCOA2","nuclear receptor coactivator 2",TRUE
+"215605_at",0.955645941042265,0.796801638607958,0.260607932370829,-5.90665789282996,0.128788355595347,"NCOA2","nuclear receptor coactivator 2",TRUE
+"205731_s_at",0.986280972175967,0.932811711372275,0.0852710900258398,-5.9361425878331,0.0520354077235758,"NCOA2","nuclear receptor coactivator 2",TRUE
+"209061_at",0.861659105448003,0.483293563640697,-0.71299105241428,-5.69506949546599,-0.484692609888599,"NCOA3","nuclear receptor coactivator 3",TRUE
+"211352_s_at",0.877510999184545,0.527742195912292,-0.641557651345245,-5.74117429691102,-0.50106216771005,"NCOA3","nuclear receptor coactivator 3",TRUE
+"1562439_at",0.878278790222455,0.531126662111742,-0.636258007068341,-5.74440895536053,-0.410053329801403,"NCOA3","nuclear receptor coactivator 3",TRUE
+"207700_s_at",0.9116561917482,0.630401176662277,-0.487918241458844,-5.82439168032068,-0.348626776838634,"NCOA3","nuclear receptor coactivator 3",TRUE
+"209060_x_at",0.950629206489271,0.774967544862594,-0.289397956535821,-5.89897349583583,-0.221071820492678,"NCOA3","nuclear receptor coactivator 3",TRUE
+"209062_x_at",0.960588243569671,0.820897801246344,-0.229093360272125,-5.91415285423656,-0.17135880419676,"NCOA3","nuclear receptor coactivator 3",TRUE
+"210774_s_at",0.968451827985008,0.852111888584904,0.188614500669427,-5.92237084031382,0.0542419073178131,"NCOA4","nuclear receptor coactivator 4",TRUE
+"234471_s_at",0.740270784944871,0.228711131590465,-1.23789834868045,-5.21966156819355,-0.39614822642149,"NCOA5","nuclear receptor coactivator 5",TRUE
+"225145_at",0.836504725924394,0.418244713170465,-0.824857674980003,-5.61361518333882,-0.2527283380019,"NCOA5","nuclear receptor coactivator 5",TRUE
+"208979_at",0.836831223244564,0.418897736606868,-0.823683416597063,-5.61452809269703,-0.366184457186984,"NCOA6","nuclear receptor coactivator 6",TRUE
+"1568874_at",0.843461221384182,0.438214164693902,0.789453418218472,-5.64060309234383,0.343242093995975,"NCOA6","nuclear receptor coactivator 6",TRUE
+"225344_at",0.39657361496013,0.0137141671957835,2.67719123608032,-2.94634743840189,1.89280033958341,"NCOA7","nuclear receptor coactivator 7",TRUE
+"243807_at",0.594975886008611,0.0717779779444499,1.89095540676261,-4.3336880865697,2.08165252841754,"NCOA7","nuclear receptor coactivator 7",TRUE
+"1568805_at",0.73148417124022,0.214675720378977,1.27742567161623,-5.17468131326202,1.39443014800471,"NCOA7","nuclear receptor coactivator 7",TRUE
+"200855_at",0.554642754132296,0.0509917676873673,2.06331851054624,-4.05491565007063,0.642971637652554,"NCOR1","nuclear receptor corepressor 1",TRUE
+"200854_at",0.569000095699173,0.0587888713416484,1.99240528509829,-4.17159241391078,0.633532593599655,"NCOR1","nuclear receptor corepressor 1",TRUE
+"200857_s_at",0.626839388794963,0.0973323687486713,1.7311302661897,-4.57679243535488,0.511723227788902,"NCOR1","nuclear receptor corepressor 1",TRUE
+"200856_x_at",0.756952614607938,0.252480191528376,1.17496892709733,-5.28874751208979,0.360065945430609,"NCOR1","nuclear receptor corepressor 1",TRUE
+"234313_at",0.988224361618126,0.943799583148583,-0.0712988375889421,-5.93720778680721,-0.0433591909428399,"NCOR1","nuclear receptor corepressor 1",TRUE
+"215205_x_at",0.860085676417428,0.478726791650031,0.720539053476335,-5.68992686784281,0.479499440225838,"NCOR2","nuclear receptor corepressor 2",TRUE
+"208889_s_at",0.9037138034254,0.605266922403228,-0.524313269688588,-5.80666744955074,-0.151235257627692,"NCOR2","nuclear receptor corepressor 2",TRUE
+"236025_at",0.904381089098038,0.607963246350011,-0.52037528663547,-5.80864518109205,-0.367409401790107,"NCOR2","nuclear receptor corepressor 2",TRUE
+"208888_s_at",0.959584210327095,0.817520473703887,0.233495445497579,-5.91316357212585,0.105309637708642,"NCOR2","nuclear receptor corepressor 2",TRUE
+"207760_s_at",0.973936963444057,0.873896494799845,0.16055788607096,-5.92713535518197,0.0695229927717644,"NCOR2","nuclear receptor corepressor 2",TRUE
+"207860_at",0.631316839203356,0.102575404006521,1.70290294789622,-4.61808726584843,1.21965758558893,"NCR1","natural cytotoxicity triggering receptor 1",TRUE
+"217088_s_at",0.789406360796076,0.316145416408959,-1.02560475714442,-5.43994729200597,-0.672660782623538,"NCR1","natural cytotoxicity triggering receptor 1",TRUE
+"217095_x_at",0.961212424803935,0.824252122927852,-0.224725838499351,-5.91511585470476,-0.149771792484392,"NCR1","natural cytotoxicity triggering receptor 1",TRUE
+"221074_at",0.55937703282623,0.0538444438917015,2.03631896446252,-4.09965713958918,1.06737677982731,"NCR2","natural cytotoxicity triggering receptor 2",TRUE
+"217045_x_at",0.680123633607363,0.147261880388879,1.50182055067322,-4.89705998261025,0.370070503390338,"NCR2","natural cytotoxicity triggering receptor 2",TRUE
+"217493_x_at",0.739340500562926,0.226706499542891,1.24342829985332,-5.21344176583374,0.363829496117437,"NCR2","natural cytotoxicity triggering receptor 2",TRUE
+"221075_s_at",0.920377252397623,0.661139763839354,-0.444293323564057,-5.84399356165869,-0.290821571987693,"NCR2","natural cytotoxicity triggering receptor 2",TRUE
+"211583_x_at",0.921729477898827,0.666420851245527,-0.436887967983708,-5.84714239275188,-0.239099138025049,"NCR3","natural cytotoxicity triggering receptor 3",TRUE
+"210763_x_at",0.928167838756364,0.684271345501787,0.412037105989785,-5.85732914753294,0.266104837658792,"NCR3","natural cytotoxicity triggering receptor 3",TRUE
+"211010_s_at",0.976371465776674,0.886383785507058,-0.144536138306273,-5.9295135127917,-0.0754566238450729,"NCR3","natural cytotoxicity triggering receptor 3",TRUE
+"229715_at",0.910822859085272,0.627938854144678,-0.491453584448,-5.8227245473474,-0.524281620952105,"NCR3LG1","natural killer cell cytotoxicity receptor 3 ligand 1",TRUE
+"230138_at",0.710371483266978,0.18306601187438,-1.37438293297514,-5.05929041158797,-0.654345934418158,"NCS1","neuronal calcium sensor 1",TRUE
+"238753_at",0.716472449896956,0.192390921397424,1.34449952456944,-5.09561120679208,0.582133786897142,"NCS1","neuronal calcium sensor 1",TRUE
+"222570_at",0.915353407558177,0.642708417512627,0.470340837676174,-5.83250575887982,0.343947416652762,"NCS1","neuronal calcium sensor 1",TRUE
+"230146_s_at",0.970573392456845,0.860104654985259,0.178303751973845,-5.92421051142462,0.089613451129674,"NCS1","neuronal calcium sensor 1",TRUE
+"218266_s_at",0.98539961718117,0.928329156665135,0.0909759741935233,-5.93565304434568,0.065095510755194,"NCS1","neuronal calcium sensor 1",TRUE
+"237076_at",0.29806620002593,0.00545830147138842,-3.07896115876315,-2.14749944915079,-2.10254888881127,"NCSTN","nicastrin",TRUE
+"208759_at",0.976422537443518,0.887770859612496,0.142758927145537,-5.92976195231688,0.051674014502753,"NCSTN","nicastrin",TRUE
+"1553551_s_at",0.975449397348071,0.882722585598743,0.149229416218508,-5.92884268525948,0.0356867588698844,"ND2","MTND2",TRUE
+"224373_s_at",0.8920930097751,0.564220276457093,-0.585360408224667,-5.77415687064481,-0.125436335910299,"ND4","NADH dehydrogenase, subunit 4 (complex I)",TRUE
+"224372_at",0.970036398574599,0.858085238537914,-0.180906907373237,-5.92375577499572,-0.0392599057362872,"ND4","NADH dehydrogenase, subunit 4 (complex I)",TRUE
+"1553575_at",0.907869873372375,0.617434538115746,0.506607723927808,-5.81544529030404,0.131377262586884,"ND6","NADH dehydrogenase, subunit 6 (complex I)",TRUE
+"218073_s_at",0.888232641270866,0.554016171318914,0.600882404912173,-5.76533835087397,0.247061579084908,"NDC1","NDC1 transmembrane nucleoporin",TRUE
+"234672_s_at",0.98539961718117,0.928566082303504,-0.0906743665365347,-5.93567971853245,-0.0294079698825502,"NDC1","NDC1 transmembrane nucleoporin",TRUE
+"204162_at",0.627092759817312,0.098738503856004,1.72343514733448,-4.58810016196363,1.01795894574346,"NDC80","NDC80, kinetochore complex component",TRUE
+"230219_at",0.640839095542136,0.111285501603033,-1.65860975040475,-4.68185307994619,-0.554594631391854,"NDE1","nudE neurodevelopment protein 1",TRUE
+"227843_at",0.711977799428804,0.185792259875204,1.36552421449911,-5.07012689315862,0.411396170867453,"NDE1","nudE neurodevelopment protein 1",TRUE
+"222625_s_at",0.829044392052913,0.400315853437335,0.857561622065882,-5.58770206128342,0.233338385636571,"NDE1","nudE neurodevelopment protein 1",TRUE
+"227249_at",0.953983577550391,0.788600203408246,-0.271394489756257,-5.90387239889278,-0.128044715501998,"NDE1","nudE neurodevelopment protein 1",TRUE
+"218414_s_at",0.968451827985008,0.851785750508645,0.189035658922225,-5.92229350560467,0.0738698895314833,"NDE1","nudE neurodevelopment protein 1",TRUE
+"243096_at",0.399719600134805,0.0142001938276038,2.66163975483909,-2.97629167598983,1.79259535548092,"NDEL1","nudE neurodevelopment protein 1 like 1",TRUE
+"208093_s_at",0.906222238025079,0.612773408951734,0.513370625864359,-5.81212715148693,0.204040816223651,"NDEL1","nudE neurodevelopment protein 1 like 1",TRUE
+"217800_s_at",0.843121215318579,0.437463175083034,-0.790766557432608,-5.63962198644737,-0.202600641967349,"NDFIP1","Nedd4 family interacting protein 1",TRUE
+"222422_s_at",0.932830928398943,0.703517200018639,-0.385535679461632,-5.86754567900547,-0.113158075092379,"NDFIP1","Nedd4 family interacting protein 1",TRUE
+"222423_at",0.990623482682449,0.952581946047098,-0.0601417110635185,-5.93792191457975,-0.0219349832329954,"NDFIP1","Nedd4 family interacting protein 1",TRUE
+"224801_at",0.0681210092794308,0.000181031209988317,4.48662703273961,0.850258301667211,1.74986560394816,"NDFIP2","Nedd4 family interacting protein 2",TRUE
+"224799_at",0.0923821310498588,0.000363276784192403,4.20250419433699,0.23660114661165,1.5450107800519,"NDFIP2","Nedd4 family interacting protein 2",TRUE
+"224802_at",0.112518135066489,0.000583555605739661,4.00891140382825,-0.181467604040466,1.45610721085582,"NDFIP2","Nedd4 family interacting protein 2",TRUE
+"230190_at",0.620912785033482,0.0905525532697733,1.76962454552184,-4.5196672370404,0.66502018532235,"NDFIP2","Nedd4 family interacting protein 2",TRUE
+"209550_at",0.63536994525358,0.106516706322713,1.68248089840977,-4.64764539458294,1.47722377632943,"NDN","necdin, MAGE family member",TRUE
+"219747_at",0.889452275006221,0.557502996575932,-0.595561839388649,-5.76838624959251,-0.225783656444467,"NDNF","neuron derived neurotrophic factor",TRUE
+"227739_at",0.438309018314998,0.0200883550337573,-2.50493061443434,-3.27323640498859,-1.11420074881612,"NDOR1","NADPH dependent diflavin oxidoreductase 1",TRUE
+"234318_x_at",0.639656559005154,0.110033297103904,1.66479293959506,-4.67302813534847,0.70474150026071,"NDOR1","NADPH dependent diflavin oxidoreductase 1",TRUE
+"234935_at",0.834111777111252,0.411984882145989,0.836173156492175,-5.60475578739254,0.344487769608631,"NDOR1","NADPH dependent diflavin oxidoreductase 1",TRUE
+"219899_x_at",0.925375904025762,0.676662618069501,0.422596558461194,-5.8530722822882,0.247069011227667,"NDOR1","NADPH dependent diflavin oxidoreductase 1",TRUE
+"206022_at",0.969270009913181,0.854199762719916,0.185919148838528,-5.92286170070142,0.236808077938174,"NDP","NDP, norrin cystine knot growth factor",TRUE
+"200632_s_at",0.855405088766616,0.468368471635501,0.737817044414835,-5.67796127082286,0.780785153469003,"NDRG1","N-myc downstream regulated 1",TRUE
+"214278_s_at",0.654592482818544,0.123480071675061,1.60126833214954,-4.76249062184988,0.993122626751138,"NDRG2","NDRG family member 2",TRUE
+"206453_s_at",0.913572663544659,0.637449977794874,-0.477832316380163,-5.82908314666759,-0.388458296979326,"NDRG2","NDRG family member 2",TRUE
+"214279_s_at",0.979976490833035,0.904589547615042,0.12124537568663,-5.93252597336602,0.0837616223456825,"NDRG2","NDRG family member 2",TRUE
+"217286_s_at",0.84571977676742,0.44347723093395,0.780289216455424,-5.64740731546563,0.471192050402168,"NDRG3","NDRG family member 3",TRUE
+"224368_s_at",0.859064198633089,0.475721754661327,0.725528745841578,-5.6864990003916,0.327771087788435,"NDRG3","NDRG family member 3",TRUE
+"221082_s_at",0.947062793209778,0.75958707806146,0.309827871112686,-5.8930365284866,0.114079590691818,"NDRG3","NDRG family member 3",TRUE
+"209159_s_at",0.100788021093145,0.000462234184097697,4.1041612607995,0.024133762193105,3.78656207280079,"NDRG4","NDRG family member 4",TRUE
+"1554010_at",0.775351898377291,0.292246405826738,-1.07888073004537,-5.38811508150117,-0.452439870795535,"NDST1","N-deacetylase and N-sulfotransferase 1",TRUE
+"202608_s_at",0.897011777275924,0.582443861755128,-0.557993276324621,-5.78916053248185,-0.194039543587855,"NDST1","N-deacetylase and N-sulfotransferase 1",TRUE
+"202607_at",0.974451535839172,0.875099136635137,-0.159013037850634,-5.92737551711424,-0.0569338285285603,"NDST1","N-deacetylase and N-sulfotransferase 1",TRUE
+"1559701_s_at",0.0550194051692779,9.73146126474343e-05,-4.74022993052756,1.39587503624579,-3.09820826488907,"NDST2","N-deacetylase and N-sulfotransferase 2",TRUE
+"203916_at",0.595165138423136,0.0720294050470213,-1.88915647707236,-4.33650942433674,-0.821293958338432,"NDST2","N-deacetylase and N-sulfotransferase 2",TRUE
+"220429_at",0.555096042605915,0.0513419421574415,2.05993260479305,-4.06054765185999,1.37620733501556,"NDST3","N-deacetylase and N-sulfotransferase 3",TRUE
+"1570222_at",0.851733415458562,0.456654553978639,0.757631105169932,-5.66390851376543,0.636827236107556,"NDST4","N-deacetylase and N-sulfotransferase 4",TRUE
+"208334_at",0.974670398319743,0.87611054826438,-0.157714140314248,-5.9275756510708,-0.15541403753623,"NDST4","N-deacetylase and N-sulfotransferase 4",TRUE
+"202298_at",0.405131078482972,0.01511119479221,-2.63379514027076,-3.02969908996483,-0.784643857509906,"NDUFA1","NADH:ubiquinone oxidoreductase subunit A1",TRUE
+"217860_at",0.51470556386048,0.0351296372407956,-2.24423070189724,-3.74554153152663,-0.623236922447527,"NDUFA10","NADH:ubiquinone oxidoreductase subunit A10",TRUE
+"1554719_at",0.85858555057682,0.474353794719232,-0.727806280344429,-5.6849268845834,-0.495505075449719,"NDUFA10","NADH:ubiquinone oxidoreductase subunit A10",TRUE
+"227206_at",0.88008451422627,0.535278105826802,-0.629782306409685,-5.74832639080828,-0.275550707784268,"NDUFA10","NADH:ubiquinone oxidoreductase subunit A10",TRUE
+"230501_at",0.931370027472813,0.695900004866319,-0.395989868076537,-5.86359535971279,-0.336305442448952,"NDUFA10","NADH:ubiquinone oxidoreductase subunit A10",TRUE
+"1555548_at",0.980009054680439,0.905150810131379,-0.120528506355826,-5.93261033186248,-0.0717807630833152,"NDUFA10","NADH:ubiquinone oxidoreductase subunit A10",TRUE
+"228690_s_at",0.896118635245982,0.577986035549259,-0.56464731479549,-5.78557660409281,-0.162011491897349,"NDUFA11","NADH:ubiquinone oxidoreductase subunit A11",TRUE
+"228689_at",0.951006866397403,0.77633283972206,-0.287590623221191,-5.89947938057788,-0.154570459538162,"NDUFA11","NADH:ubiquinone oxidoreductase subunit A11",TRUE
+"225304_s_at",0.960138290470901,0.819542011106874,-0.230859966800975,-5.91375809439526,-0.0780936967562518,"NDUFA11","NADH:ubiquinone oxidoreductase subunit A11",TRUE
+"223244_s_at",0.623667408398064,0.0947484692492219,-1.74552183134998,-4.55554413994483,-0.43668886284615,"NDUFA12","NADH:ubiquinone oxidoreductase subunit A12",TRUE
+"220864_s_at",0.406142422607459,0.0153235210124722,-2.62753279770913,-3.04167345948332,-0.894245120682879,"NDUFA13","NADH:ubiquinone oxidoreductase subunit A13",TRUE
+"209224_s_at",0.635626505801859,0.106587669064038,-1.68211911393135,-4.64816660151238,-0.573137054870148,"NDUFA2","NADH:ubiquinone oxidoreductase subunit A2",TRUE
+"222971_at",0.812055457762952,0.356225430371832,-0.942250781115283,-5.51626256219348,-0.572165320925325,"NDUFA2","NADH:ubiquinone oxidoreductase subunit A2",TRUE
+"209223_at",0.92051722798026,0.661881109795269,0.44325226351605,-5.84443936824678,0.153434818690815,"NDUFA2","NADH:ubiquinone oxidoreductase subunit A2",TRUE
+"218563_at",0.352457014090632,0.0093528226928397,-2.84619672836358,-2.61589786443257,-1.01573320473286,"NDUFA3","NADH:ubiquinone oxidoreductase subunit A3",TRUE
+"217773_s_at",0.914535679225538,0.639915710656267,-0.474316061560973,-5.83069619927044,-0.156676287146698,"NDUFA4","NDUFA4, mitochondrial complex associated",TRUE
+"218484_at",0.8920930097751,0.564042134477887,0.585630137336956,-5.77400553460794,0.284834955537066,"NDUFA4L2","NDUFA4, mitochondrial complex associated like 2",TRUE
+"201304_at",0.633978046140253,0.104858589037094,-1.69099306032408,-4.63535787315094,-0.508443728645062,"NDUFA5","NADH:ubiquinone oxidoreductase subunit A5",TRUE
+"215850_s_at",0.723649742218726,0.20025677128103,1.32016472674746,-5.12469326627131,0.581716275003769,"NDUFA5","NADH:ubiquinone oxidoreductase subunit A5",TRUE
+"202001_s_at",0.500677386446044,0.0319396273131506,-2.28946117400764,-3.66572552686626,-0.67717966981942,"NDUFA6","NADH:ubiquinone oxidoreductase subunit A6",TRUE
+"202000_at",0.920295529438727,0.660757018880056,-0.444831001310671,-5.84376291347728,-0.161150507720466,"NDUFA6","NADH:ubiquinone oxidoreductase subunit A6",TRUE
+"202785_at",0.896907177224677,0.582024274659163,0.55861849004354,-5.78882554088165,0.285238695808768,"NDUFA7","NADH:ubiquinone oxidoreductase subunit A7",TRUE
+"1557532_at",0.963379172403332,0.832902588974308,0.213482805190395,-5.91750997049711,0.173691399263119,"NDUFA7","NADH:ubiquinone oxidoreductase subunit A7",TRUE
+"218160_at",0.650490742096872,0.120566880257776,-1.61452012697542,-4.74404948999617,-0.502369101142822,"NDUFA8","NADH:ubiquinone oxidoreductase subunit A8",TRUE
+"208969_at",0.936992192746977,0.717806077857251,0.366041282401519,-5.87463360779459,0.114738479853536,"NDUFA9","NADH:ubiquinone oxidoreductase subunit A9",TRUE
+"202077_at",0.475296051772729,0.0262042335376774,-2.38236315944443,-3.49890380723652,-0.713826072713829,"NDUFAB1","NADH:ubiquinone oxidoreductase subunit AB1",TRUE
+"204125_at",0.758081075834994,0.254816820805711,-1.16902604023336,-5.29510948863231,-0.507474396403403,"NDUFAF1","NADH:ubiquinone oxidoreductase complex assembly factor 1",TRUE
+"228355_s_at",0.862639573412331,0.486145851654704,-0.708297761018333,-5.69824114617626,-0.309177222691385,"NDUFAF2","NADH:ubiquinone oxidoreductase complex assembly factor 2",TRUE
+"209177_at",0.662471354228862,0.130167896817205,-1.57180462486233,-4.80306756946687,-0.650290659453692,"NDUFAF3","NADH:ubiquinone oxidoreductase complex assembly factor 3",TRUE
+"234460_at",0.552986220491716,0.0503919447557817,2.06916695356175,-4.04517335534542,0.850726463264474,"Ndufaf4","NADH:ubiquinone oxidoreductase complex assembly factor 4",TRUE
+"227559_at",0.909441642299191,0.624056321187605,-0.49704098202851,-5.82006577070529,-0.220084675260748,"NDUFAF4","NADH:ubiquinone oxidoreductase complex assembly factor 4",TRUE
+"219006_at",0.978255630670068,0.894897176164068,0.133635507606734,-5.93098903024002,0.0441836494277936,"NDUFAF4","NADH:ubiquinone oxidoreductase complex assembly factor 4",TRUE
+"222894_x_at",0.597654932724127,0.0749685170894888,-1.86852484804405,-4.36873182455717,-0.718975846191691,"NDUFAF5","NADH:ubiquinone oxidoreductase complex assembly factor 5",TRUE
+"219524_s_at",0.67565343307767,0.142228201049689,1.5217027571372,-4.87070303966608,1.00344518658107,"NDUFAF5","NADH:ubiquinone oxidoreductase complex assembly factor 5",TRUE
+"227160_s_at",0.792013951867008,0.322851633148038,-1.01116821753838,-5.45358508722659,-0.421647190531012,"NDUFAF5","NADH:ubiquinone oxidoreductase complex assembly factor 5",TRUE
+"223560_s_at",0.382928576778789,0.0121514600953123,2.73097870210022,-2.84215823697764,0.812327782632089,"NDUFAF7","NADH:ubiquinone oxidoreductase complex assembly factor 7",TRUE
+"220943_s_at",0.455234810916548,0.0221643359242771,2.45985110914867,-3.35694252100409,1.02180460840545,"NDUFAF7","NADH:ubiquinone oxidoreductase complex assembly factor 7",TRUE
+"230379_x_at",0.580630437263151,0.062998270421948,1.95753119278492,-4.22796762750962,0.70403395770171,"NDUFAF7","NADH:ubiquinone oxidoreductase complex assembly factor 7",TRUE
+"206790_s_at",0.407748633394319,0.0155687783682596,-2.62039992333894,-3.0552955927207,-0.800055814109378,"NDUFB1","NADH:ubiquinone oxidoreductase subunit B1",TRUE
+"243630_at",0.931560290412494,0.69746192510494,-0.393842591704257,-5.86441524725406,-0.259669829496371,"NDUFB1","NADH:ubiquinone oxidoreductase subunit B1",TRUE
+"228301_x_at",0.555180272174837,0.0513840283172931,-2.05952705678861,-4.06122182194682,-0.67878245875494,"NDUFB10","NADH:ubiquinone oxidoreductase subunit B10",TRUE
+"223112_s_at",0.687277721925286,0.155946363387382,-1.46878603047333,-4.94023608925094,-0.560066107524962,"NDUFB10","NADH:ubiquinone oxidoreductase subunit B10",TRUE
+"218320_s_at",0.597654932724127,0.0750725541552765,-1.86780757157597,-4.36984757626319,-0.638122735964641,"NDUFB11","NADH:ubiquinone oxidoreductase subunit B11",TRUE
+"218200_s_at",0.522832264420585,0.0386367917458488,-2.19863683155271,-3.82502904786961,-0.607730491745185,"NDUFB2","NADH:ubiquinone oxidoreductase subunit B2",TRUE
+"218201_at",0.560923390313819,0.0545183106845071,-2.03012786225135,-4.10986185672795,-0.70383962837548,"NDUFB2","NADH:ubiquinone oxidoreductase subunit B2",TRUE
+"240391_at",0.919354071504066,0.656408857188215,-0.450948681807762,-5.841119338422,-0.1839812014184,"NDUFB2","NADH:ubiquinone oxidoreductase subunit B2",TRUE
+"222090_at",0.627053909308516,0.0978914154759086,-1.72805957241341,-4.58130921645118,-0.562243133358395,"NDUFB2-AS1","NDUFB2 antisense RNA 1",TRUE
+"203371_s_at",0.68033297785336,0.147880391496035,-1.49941604967776,-4.90022871237603,-0.428827452944267,"NDUFB3","NADH:ubiquinone oxidoreductase subunit B3",TRUE
+"218226_s_at",0.675158868445887,0.141362959785166,-1.52517821797166,-4.86606739257216,-0.377783099413225,"NDUFB4","NADH:ubiquinone oxidoreductase subunit B4",TRUE
+"228940_at",0.998047179825832,0.991310063251024,-0.0110149949996297,-5.93962438549633,-0.00458007387272108,"NDUFB4","NADH:ubiquinone oxidoreductase subunit B4",TRUE
+"203621_at",0.947414459608985,0.760686737309096,-0.308362820486975,-5.89347562954313,-0.0919997748342496,"NDUFB5","NADH:ubiquinone oxidoreductase subunit B5",TRUE
+"1559042_at",0.77364996239449,0.285018497137801,1.09560442505578,-5.37136071325218,0.367809301371621,"NDUFB6","NADH:ubiquinone oxidoreductase subunit B6",TRUE
+"203613_s_at",0.841391443291102,0.43191080848434,-0.800518511029132,-5.63228786929193,-0.283925150075664,"NDUFB6","NADH:ubiquinone oxidoreductase subunit B6",TRUE
+"211407_at",0.8920930097751,0.563055980395015,0.587124091601479,-5.77316610531064,0.172496329331937,"NDUFB7","NADH:ubiquinone oxidoreductase subunit B7",TRUE
+"202839_s_at",0.948429371744093,0.765783289782926,0.301581729391762,-5.89548117209888,0.104355677103444,"NDUFB7","NADH:ubiquinone oxidoreductase subunit B7",TRUE
+"214241_at",0.715119690416591,0.190854696044368,-1.34934294147613,-5.08976975304774,-0.550562340167096,"NDUFB8","NADH:ubiquinone oxidoreductase subunit B8",TRUE
+"201226_at",0.854184492233394,0.464814098824748,-0.743797747058383,-5.67375674971059,-0.322309515604257,"NDUFB8","NADH:ubiquinone oxidoreductase subunit B8",TRUE
+"201227_s_at",0.928576500287959,0.685923767801165,-0.409750186974019,-5.85823712257318,-0.128232860249621,"NDUFB8","NADH:ubiquinone oxidoreductase subunit B8",TRUE
+"222992_s_at",0.941263480204937,0.737017482415245,0.340055443141852,-5.88351703367051,0.148362119800574,"NDUFB9","NADH:ubiquinone oxidoreductase subunit B9",TRUE
+"203478_at",0.514490373584066,0.0347594371577276,-2.24928265450616,-3.73667359281549,-0.730637553700713,"NDUFC1","NADH:ubiquinone oxidoreductase subunit C1",TRUE
+"232146_at",0.948109877411639,0.764350255434297,-0.303486945457888,-5.89492215903935,-0.229927192886501,"NDUFC1","NADH:ubiquinone oxidoreductase subunit C1",TRUE
+"219545_at",0.308621629697291,0.00631519961491692,3.01643953812862,-2.27466343804106,3.92410211643564,"NDUFC2-KCTD14///KCTD14","NDUFC2-KCTD14 readthrough///potassium channel tetramerization domain containing 14",TRUE
+"58916_at",0.384135218769668,0.0123560488239334,2.72357676234389,-2.85655242815256,2.66732022698718,"NDUFC2-KCTD14///KCTD14","NDUFC2-KCTD14 readthrough///potassium channel tetramerization domain containing 14",TRUE
+"222521_x_at",0.788120945317721,0.314292687337968,-1.02963091667699,-5.43611275118621,-0.327719793982068,"NDUFC2-KCTD14///NDUFC2","NDUFC2-KCTD14 readthrough///NADH:ubiquinone oxidoreductase subunit C2",TRUE
+"218101_s_at",0.983783029912313,0.920862014553078,-0.10048627031341,-5.93476656183897,-0.0266684383755944,"NDUFC2-KCTD14///NDUFC2","NDUFC2-KCTD14 readthrough///NADH:ubiquinone oxidoreductase subunit C2",TRUE
+"236356_at",0.597346378847428,0.0734106543752295,-1.87937068616925,-4.35182387615835,-0.831681744743013,"NDUFS1","NADH:ubiquinone oxidoreductase core subunit S1",TRUE
+"203039_s_at",0.695744345349551,0.165264346134784,-1.43496089306185,-4.98363833077969,-0.422224576716806,"NDUFS1","NADH:ubiquinone oxidoreductase core subunit S1",TRUE
+"229647_at",0.817517099085723,0.369958983889645,-0.915163207378074,-5.53978750117701,-0.259155145219262,"NDUFS1","NADH:ubiquinone oxidoreductase core subunit S1",TRUE
+"239268_at",0.859807554381411,0.47809545986838,0.721585820792541,-5.68920961374182,0.336401562253651,"NDUFS1","NADH:ubiquinone oxidoreductase core subunit S1",TRUE
+"235321_at",0.899889458546239,0.593918017421304,-0.540981724855243,-5.79813555095123,-0.325090784843219,"NDUFS1","NADH:ubiquinone oxidoreductase core subunit S1",TRUE
+"201966_at",0.597346378847428,0.0732701538227806,-1.88035870645577,-4.35028019250237,-0.62595862865146,"NDUFS2","NADH:ubiquinone oxidoreductase core subunit S2",TRUE
+"201740_at",0.623418029554799,0.0940343573797609,-1.74955842938584,-4.54956095809306,-0.634418289855352,"NDUFS3","NADH:ubiquinone oxidoreductase core subunit S3",TRUE
+"1555057_at",0.708894565317004,0.181198921086838,1.38051034405668,-5.05176094128225,1.15873443335604,"NDUFS4","NADH:ubiquinone oxidoreductase subunit S4",TRUE
+"209303_at",0.845588139978284,0.443059436391374,-0.781014251898302,-5.64687171962066,-0.298871939189871,"NDUFS4","NADH:ubiquinone oxidoreductase subunit S4",TRUE
+"203606_at",0.842224301155785,0.435689079296952,0.793874163404743,-5.63729404011824,0.361592171360289,"NDUFS6","NADH:ubiquinone oxidoreductase subunit S6",TRUE
+"211752_s_at",0.47652109797903,0.0263847844559211,-2.37916457602126,-3.50470985424594,-0.816935560018937,"NDUFS7","NADH:ubiquinone oxidoreductase core subunit S7",TRUE
+"242168_at",0.70939075283402,0.182367981903305,1.37666790256467,-5.05648585430699,0.86020714600023,"NDUFS7","NADH:ubiquinone oxidoreductase core subunit S7",TRUE
+"208714_at",0.942502815705589,0.742487731336033,0.332700483330814,-5.88591398907377,0.11551565792448,"NDUFV1","NADH:ubiquinone oxidoreductase core subunit V1",TRUE
+"227795_at",0.980335118024956,0.908345259792305,-0.11644963387327,-5.9330808103657,-0.0422995340093069,"NDUFV1","NADH:ubiquinone oxidoreductase core subunit V1",TRUE
+"202941_at",0.784789297644843,0.30920695820914,1.04076921858799,-5.42543400575263,0.376235340384392,"NDUFV2","NADH:ubiquinone oxidoreductase core subunit V2",TRUE
+"239450_at",0.669423128374382,0.135541070695894,1.54902933265101,-4.83402791384903,1.22164011525674,"NDUFV2-AS1","NDUFV2 antisense RNA 1",TRUE
+"242676_at",0.7768734672127,0.294996760013387,1.07259515308066,-5.39435269462148,0.538540155955111,"NDUFV2-AS1","NDUFV2 antisense RNA 1",TRUE
+"226616_s_at",0.623503825356688,0.0946158421558264,-1.74626954633098,-4.55443662261768,-0.779624330540511,"NDUFV3","NADH:ubiquinone oxidoreductase subunit V3",TRUE
+"226209_at",0.893672674459235,0.569155486005396,-0.577905192809253,-5.77831303742938,-0.24132738910519,"NDUFV3","NADH:ubiquinone oxidoreductase subunit V3",TRUE
+"215368_at",0.797508506396963,0.330996367480027,0.993913215642988,-5.46965552023538,0.469091150648446,"NEB","nebulin",TRUE
+"205054_at",0.899808883319249,0.592970886334437,0.542379772936914,-5.79740814530551,0.27592481502816,"NEB","nebulin",TRUE
+"216882_s_at",0.518874125067442,0.0372674252067504,-2.21597256652958,-3.79492285648504,-1.40452692916979,"NEBL","nebulette",TRUE
+"207279_s_at",0.579111490485788,0.0620817705231355,-1.96494475017865,-4.21603986133271,-1.18396717762727,"NEBL","nebulette",TRUE
+"217585_at",0.5897618614591,0.0679293963532043,-1.91920427568241,-4.28913876582074,-1.21943598014708,"NEBL","nebulette",TRUE
+"203962_s_at",0.724652102844753,0.202165583062167,-1.314372300817,-5.13154972603464,-1.59503034595513,"NEBL","nebulette",TRUE
+"203961_at",0.754513748034606,0.247888165674736,-1.1867685904241,-5.27603223161736,-1.52635109338586,"NEBL","nebulette",TRUE
+"241782_at",0.890791272165577,0.559581472954713,-0.59239852113794,-5.77018594699128,-0.586256482782182,"NEBL","nebulette",TRUE
+"239894_at",0.635174103121116,0.106010150726516,-1.68506938317543,-4.6439138070392,-1.59656667123895,"NEBL-AS1","NEBL antisense RNA 1",TRUE
+"233305_at",0.986145735582101,0.932306206324761,0.0859142905407456,-5.93608897793533,0.123932801134699,"NECAB1","N-terminal EF-hand calcium binding protein 1",TRUE
+"215005_at",0.821962235882611,0.385146111766481,-0.885974998171379,-5.56442769622893,-0.573999211364955,"NECAB2","N-terminal EF-hand calcium binding protein 2",TRUE
+"210720_s_at",0.908801761853008,0.621157695189342,-0.501222900050887,-5.81805659269184,-0.258209076088349,"NECAB3","N-terminal EF-hand calcium binding protein 3",TRUE
+"223954_x_at",0.975398143273847,0.881683763599156,-0.150561698685829,-5.92864835957216,-0.0493612445369962,"NECAB3","N-terminal EF-hand calcium binding protein 3",TRUE
+"209300_s_at",0.708309103286544,0.180164409124442,-1.38392698829734,-5.04755043701954,-0.576038200797727,"NECAP1","NECAP endocytosis associated 1",TRUE
+"230123_at",0.822010986888098,0.385785823892403,0.884762258134127,-5.56543547516804,0.380174180653576,"NECAP2","NECAP endocytosis associated 2",TRUE
+"220731_s_at",0.901781358899845,0.598914632379131,0.533624221644059,-5.80193357987295,0.17159147776251,"NECAP2","NECAP endocytosis associated 2",TRUE
+"211846_s_at",0.73936001229895,0.227070392006637,-1.24242171160287,-5.21457570009577,-0.557206879771197,"NECTIN1","nectin cell adhesion molecule 1",TRUE
+"208455_at",0.821903997044289,0.385043419849884,0.886169799828178,-5.5642656980852,0.678901862889224,"NECTIN1","nectin cell adhesion molecule 1",TRUE
+"211845_at",0.897375964261386,0.583740668529072,0.556062363539484,-5.79019282360164,0.233027536401862,"NECTIN1","nectin cell adhesion molecule 1",TRUE
+"225211_at",0.899842372425294,0.593805446677725,0.541147831934903,-5.79804922082736,0.278218339028884,"NECTIN1","nectin cell adhesion molecule 1",TRUE
+"232078_at",0.609827382478528,0.081934923670549,-1.82230460193527,-4.44000532378557,-1.10263000368073,"NECTIN2","nectin cell adhesion molecule 2",TRUE
+"232079_s_at",0.612420348961838,0.0841793877355563,-1.80813941634199,-4.46159214321572,-1.07926785226485,"NECTIN2","nectin cell adhesion molecule 2",TRUE
+"225418_at",0.70573152022539,0.177918064905465,-1.39139989857132,-5.0383111321457,-0.772419935443994,"NECTIN2","nectin cell adhesion molecule 2",TRUE
+"203149_at",0.795405659274621,0.327502006430549,-1.00127967631324,-5.46282546743089,-0.452001745707557,"NECTIN2","nectin cell adhesion molecule 2",TRUE
+"227503_at",0.554642754132296,0.0511848440066413,2.06144905485811,-4.05802598590785,3.09867819758211,"NECTIN3","nectin cell adhesion molecule 3",TRUE
+"213325_at",0.64513208805899,0.11609655654581,1.63538581328456,-4.71477508808715,1.8084753154565,"NECTIN3","nectin cell adhesion molecule 3",TRUE
+"223540_at",0.943988850936011,0.749539693713451,-0.323246324569455,-5.88891888740676,-0.277335555295799,"NECTIN4","nectin cell adhesion molecule 4",TRUE
+"234984_at",0.861659105448003,0.483412473159768,-0.71279507283678,-5.69520233434717,-0.238161811118092,"NEDD1","neural precursor cell expressed, developmentally down-regulated 1",TRUE
+"1560116_a_at",0.992179245947777,0.96359038914433,-0.0461674364842683,-5.93864539203563,-0.0152869996814839,"NEDD1","neural precursor cell expressed, developmentally down-regulated 1",TRUE
+"1552417_a_at",0.994061569423518,0.972401566791687,-0.0349893232235951,-5.93908720996931,-0.0131556453448933,"NEDD1","neural precursor cell expressed, developmentally down-regulated 1",TRUE
+"213012_at",0.676468346171966,0.143290973037088,-1.51745752587592,-4.87635398906172,-0.666540622522923,"NEDD4","neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase",TRUE
+"241396_at",0.620223198657182,0.0901603145746617,-1.77192640653854,-4.51622200595353,-1.1150358712065,"NEDD4L","neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase",TRUE
+"237498_at",0.69381587860958,0.163038800336093,1.44289715133819,-4.9735289779493,0.813324706830041,"NEDD4L","neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase",TRUE
+"236490_at",0.7569746234637,0.252643309171753,1.17455273434575,-5.2891939733477,0.627635572650718,"NEDD4L","neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase",TRUE
+"212448_at",0.961778365989609,0.826637266157654,-0.221622965486699,-5.91578880361937,-0.187084956608944,"NEDD4L","neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase",TRUE
+"212445_s_at",0.965707350334601,0.839672633098414,-0.204703427068791,-5.91929441898185,-0.1072943959791,"NEDD4L","neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase",TRUE
+"226974_at",0.994304286761558,0.974110353899681,-0.0328220810185922,-5.93915878661717,-0.0229304884832811,"NEDD4L","neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase",TRUE
+"201840_at",0.597346378847428,0.0734383314419784,-1.87917625186103,-4.35212759325384,-0.591538619107036,"NEDD8","neural precursor cell expressed, developmentally down-regulated 8",TRUE
+"228763_at",0.296090407530139,0.00531944513659262,-3.0899744369884,-2.12500514839512,-1.15388826205959,"NEDD8-MDP1///MDP1","NEDD8-MDP1 readthrough///magnesium dependent phosphatase 1",TRUE
+"228764_s_at",0.461321138453616,0.0231694164827367,-2.43941978807837,-3.39461344913018,-0.853312186519826,"NEDD8-MDP1///MDP1","NEDD8-MDP1 readthrough///magnesium dependent phosphatase 1",TRUE
+"202149_at",0.65284137151906,0.122208153222389,1.60702168244198,-4.7544987638779,1.71235339794285,"NEDD9","neural precursor cell expressed, developmentally down-regulated 9",TRUE
+"242861_at",0.657015752622694,0.125783437058241,1.59097399362351,-4.7767346371993,0.539645574015659,"NEDD9","neural precursor cell expressed, developmentally down-regulated 9",TRUE
+"202150_s_at",0.664123571602771,0.132200769329962,1.56309796839543,-4.81494523169171,1.36712063929927,"NEDD9","neural precursor cell expressed, developmentally down-regulated 9",TRUE
+"1569020_at",0.76912869907427,0.274600316187474,1.12025827516336,-5.34624410893355,0.520481113049885,"NEDD9","neural precursor cell expressed, developmentally down-regulated 9",TRUE
+"1560706_at",0.809930331505913,0.353686990329039,-0.947333920866812,-5.51177776008346,-0.655313343869455,"NEDD9","neural precursor cell expressed, developmentally down-regulated 9",TRUE
+"204412_s_at",0.498206796273596,0.031150485471549,2.30128677259122,-3.64470308866719,1.89120670938262,"NEFH","neurofilament heavy polypeptide",TRUE
+"33767_at",0.812302873476553,0.357746492528318,0.939216594340635,-5.51892904220002,0.842293677712806,"NEFH","neurofilament heavy polypeptide",TRUE
+"221805_at",0.877944644261883,0.529488842583468,-0.638820325142319,-5.74284825522945,-0.533379010420557,"NEFL","neurofilament, light polypeptide",TRUE
+"221916_at",0.973433731874338,0.871719476543783,-0.163355385660549,-5.92669456162971,-0.061754609842736,"NEFL","neurofilament, light polypeptide",TRUE
+"221801_x_at",0.982476966653206,0.915328699436522,0.107539686705258,-5.93405227008664,0.0818722718694538,"NEFL","neurofilament, light polypeptide",TRUE
+"205113_at",0.9202957869034,0.660893612984346,-0.444639099480005,-5.8438452652139,-0.336521850848149,"NEFM","neurofilament, medium polypeptide",TRUE
+"223902_at",0.990180560227117,0.951315860048839,-0.06174963190074,-5.93782647137308,-0.0247610256726523,"NEFM","neurofilament, medium polypeptide",TRUE
+"243357_at",0.679862743105294,0.14707666255966,1.50254220165263,-4.89610817342049,1.30250896498824,"NEGR1","neuronal growth regulator 1",TRUE
+"1553194_at",0.902521078772712,0.601596047212665,0.529688126074069,-5.8039446633423,0.623301214842819,"NEGR1","neuronal growth regulator 1",TRUE
+"229461_x_at",0.92247975200053,0.668772086793303,0.433598964557024,-5.84852424697262,0.814361893178755,"NEGR1","neuronal growth regulator 1",TRUE
+"239548_at",0.97928472590149,0.899923603077372,-0.127207483529653,-5.93180502200543,-0.151484731086777,"NEGR1","neuronal growth regulator 1",TRUE
+"1563316_at",0.64513208805899,0.115882694748972,1.63640081840219,-4.7133436648956,0.794992509346129,"NEGR1-IT1","NEGR1 intronic transcript 1",TRUE
+"226585_at",0.984132887597385,0.922266359762021,0.098696971300334,-5.93494006739294,0.0772332242889586,"NEIL2","nei like DNA glycosylase 2",TRUE
+"219502_at",0.928777626237599,0.686608321140322,0.40880343050436,-5.85861155780013,0.166845576364301,"NEIL3","nei like DNA glycosylase 3",TRUE
+"216213_at",0.7768734672127,0.294867365685212,1.07288992336886,-5.39406090178219,0.384812166322165,"NEK1","NIMA related kinase 1",TRUE
+"211086_x_at",0.837609393049242,0.421927477019066,0.818250369320654,-5.61873607400017,0.604976681291892,"NEK1","NIMA related kinase 1",TRUE
+"1564093_at",0.854184492233394,0.464350497946612,0.744579816188308,-5.67320456453197,0.640105524858635,"NEK1","NIMA related kinase 1",TRUE
+"213328_at",0.928114879020015,0.684110016678803,0.412260501424959,-5.85724018634098,0.156263249184671,"NEK1","NIMA related kinase 1",TRUE
+"213331_s_at",0.943919772060845,0.748755322565488,0.324296385467652,-5.88858936974214,0.136317091045331,"NEK1","NIMA related kinase 1",TRUE
+"237227_at",0.93523910610914,0.711894589330518,0.374088407743067,-5.87175173283231,0.154273853004437,"NEK10","NIMA related kinase 10",TRUE
+"1555082_a_at",0.720507507563255,0.196620562630735,-1.33131938100735,-5.11141799786976,-0.411855709108354,"NEK11","NIMA related kinase 11",TRUE
+"1554380_at",0.932018790587499,0.699380482118739,-0.391207598539211,-5.86541535645758,-0.266285456140466,"NEK11","NIMA related kinase 11",TRUE
+"219542_at",0.93789466363241,0.725319959465315,-0.355848214045642,-5.87819517191193,-0.13259566970528,"NEK11","NIMA related kinase 11",TRUE
+"211080_s_at",0.913342687538603,0.636745584697494,0.478837936582595,-5.82861968359311,0.174865340635634,"NEK2","NIMA related kinase 2",TRUE
+"204641_at",0.978685208055271,0.89668508115813,0.131348406655633,-5.93128396282503,0.0518855076333828,"NEK2","NIMA related kinase 2",TRUE
+"211089_s_at",0.896118635245982,0.578304356074137,-0.564171317650331,-5.78583434905762,-0.276950741579964,"NEK3","NIMA related kinase 3",TRUE
+"213116_at",0.928246500493356,0.684662472009305,-0.411495593331347,-5.85754459345006,-0.235354459301695,"NEK3","NIMA related kinase 3",TRUE
+"204634_at",0.632949074657601,0.10419959548373,-1.69440781337245,-4.63041544730775,-0.586370166757396,"NEK4","NIMA related kinase 4",TRUE
+"1554659_at",0.790240875783718,0.319606991034314,1.01812653701621,-5.44703358129073,0.658061807394222,"NEK4","NIMA related kinase 4",TRUE
+"241310_at",0.384135218769668,0.012352782882742,-2.7236940093608,-2.85632456160663,-1.8414855466191,"NEK5","NIMA related kinase 5",TRUE
+"237168_at",0.834257102482644,0.412116142312826,-0.835934774208901,-5.60494359128649,-0.482059718132404,"NEK5","NIMA related kinase 5",TRUE
+"223158_s_at",0.447294524001345,0.0212278946704073,-2.47967686008079,-3.32022785774379,-1.15262791120508,"NEK6","NIMA related kinase 6",TRUE
+"223159_s_at",0.555307820043702,0.0514742765436938,-2.05865841290713,-4.06266553618924,-0.955695680122011,"NEK6","NIMA related kinase 6",TRUE
+"237406_at",0.866807918403275,0.498317448399666,-0.688446118483974,-5.71143559866289,-0.54075616695765,"NEK6","NIMA related kinase 6",TRUE
+"239267_at",0.922168942129244,0.667715587385099,0.43507623516726,-5.84790484935558,0.14253859043899,"NEK6","NIMA related kinase 6",TRUE
+"223561_at",0.937271400689562,0.721924291436668,-0.360449835429446,-5.87659961595787,-0.176678941490366,"NEK6","NIMA related kinase 6",TRUE
+"212530_at",0.812750247585179,0.361460174124942,0.93184486804421,-5.52537449407078,0.354215009949664,"NEK7","NIMA related kinase 7",TRUE
+"1557172_x_at",0.722937902375896,0.199637319632396,1.32205375077413,-5.12245173968292,0.673270685104023,"NEK8","NIMA related kinase 8",TRUE
+"1557170_at",0.823073978212882,0.389008773132128,0.878672189506636,-5.57047692571928,0.279948258344902,"NEK8","NIMA related kinase 8",TRUE
+"214738_s_at",0.947062793209778,0.75969740009976,0.309680860427474,-5.89308068321631,0.241186709970495,"NEK9","NIMA related kinase 9",TRUE
+"230153_at",0.947969282616012,0.763436107880891,-0.304702901463833,-5.89456355898706,-0.119284108197465,"NEK9","NIMA related kinase 9",TRUE
+"212299_at",0.954054753819891,0.789167221676659,-0.270647700841887,-5.90406886201776,-0.183426043206707,"NEK9","NIMA related kinase 9",TRUE
+"202757_at",0.786851686785014,0.312644807366392,-1.0332259591819,-5.43267735592889,-0.29398416853282,"NELFB","negative elongation factor complex member B",TRUE
+"225006_x_at",0.575942796287027,0.0610230748768313,-1.97362993032214,-4.2020272107844,-0.819070024049319,"NELFCD","negative elongation factor complex member C/D",TRUE
+"225865_x_at",0.592488489935347,0.0694690043614688,-1.90773904005921,-4.30727523532046,-0.784526852577718,"NELFCD","negative elongation factor complex member C/D",TRUE
+"225261_x_at",0.640067422642767,0.110630950480748,-1.66183445518252,-4.67725374660749,-0.734270618198776,"NELFCD","negative elongation factor complex member C/D",TRUE
+"220607_x_at",0.690231018155546,0.159810415342132,-1.4545661813036,-4.95858225423963,-0.642691267951548,"NELFCD","negative elongation factor complex member C/D",TRUE
+"206089_at",0.868397087637799,0.503732625169999,-0.679702969963104,-5.71713312755734,-0.516483707159575,"NELL1","neural EGFL like 1",TRUE
+"1554394_at",0.986342822130003,0.933576350937919,0.0842982388011525,-5.93622290872681,0.0743412057324973,"NELL1","neural EGFL like 1",TRUE
+"203413_at",0.89961817630669,0.590468240163917,-0.546079174602504,-5.79547454179716,-0.523381005758034,"NELL2","neural EGFL like 2",TRUE
+"1558675_s_at",0.584828007864693,0.0650771577475774,-1.941061803683,-4.25435516508795,-0.537818413607971,"NEMF","nuclear export mediator factor",TRUE
+"1557950_at",0.622434989367596,0.093077795575116,-1.75500685851815,-4.54146893292027,-0.564495293264573,"NEMF","nuclear export mediator factor",TRUE
+"218649_x_at",0.645740804644555,0.116926389243877,-1.63146216403997,-4.7203020409382,-0.463771371553205,"NEMF","nuclear export mediator factor",TRUE
+"1569594_a_at",0.816800680706682,0.36897966177591,-0.917072339880595,-5.53815015765361,-0.273775969775086,"NEMF","nuclear export mediator factor",TRUE
+"212621_at",0.518754140382047,0.0371967183315835,-2.21688332519115,-3.79333720315036,-0.75155487872895,"NEMP1","nuclear envelope integral membrane protein 1",TRUE
+"212619_at",0.680160698079016,0.147364409679292,-1.50142139193276,-4.89758628877561,-0.567526024066817,"NEMP1","nuclear envelope integral membrane protein 1",TRUE
+"238014_at",0.723649742218726,0.200158922893303,1.32046281285675,-5.1243397352302,0.558872105179073,"NEMP2","nuclear envelope integral membrane protein 2",TRUE
+"214125_s_at",0.748184017928985,0.240355850349663,1.20648299123266,-5.25454128399675,0.559401427377193,"NENF","neudesin neurotrophic factor",TRUE
+"213673_x_at",0.759006467075996,0.256598596643967,1.16452151126901,-5.29991285574426,0.744605855125458,"NENF","neudesin neurotrophic factor",TRUE
+"214075_at",0.807544796225587,0.348935204895375,0.956915905737677,-5.50326356705159,0.260603018643899,"NENF","neudesin neurotrophic factor",TRUE
+"214072_x_at",0.98453870130544,0.924742338509474,-0.0955430867444025,-5.93523831185779,-0.0309906080685609,"NENF","neudesin neurotrophic factor",TRUE
+"218406_x_at",0.984802091612958,0.925483359582171,-0.0945993737330483,-5.93532567236353,-0.0637398137628606,"NENF","neudesin neurotrophic factor",TRUE
+"218407_x_at",0.990810941805126,0.954473239681266,0.057740081941829,-5.9380597831223,0.0185845425028432,"NENF","neudesin neurotrophic factor",TRUE
+"225270_at",0.218511506433,0.00264989433333852,-3.38438314661324,-1.51458933093591,-2.3007421791022,"NEO1","neogenin 1",TRUE
+"204321_at",0.506114211039982,0.0331603299492173,-2.27168514791517,-3.69720643186676,-1.89135166398767,"NEO1","neogenin 1",TRUE
+"229877_at",0.97345342693821,0.871897352914332,0.163126762218157,-5.92673087010104,0.138769685141976,"NEO1","neogenin 1",TRUE
+"225279_s_at",0.877510999184545,0.527702810127822,0.641619433156182,-5.74113643607074,0.384743306878967,"NEPRO","nucleolus and neural progenitor protein",TRUE
+"225281_at",0.978547559181165,0.896451580142043,-0.131647061839676,-5.93124573833045,-0.0449645225947961,"NEPRO","nucleolus and neural progenitor protein",TRUE
+"218678_at",0.896115372949367,0.577240806676128,0.565762200683964,-5.7849720859593,0.690651997084381,"NES","nestin",TRUE
+"229346_at",0.953564723226096,0.786181383700663,0.274581962884772,-5.90302780457042,0.193338820464554,"NES","nestin",TRUE
+"201830_s_at",0.597654932724127,0.0747666704097682,1.8699189468557,-4.36656238342308,1.01838206134669,"NET1","neuroepithelial cell transforming 1",TRUE
+"201829_at",0.599731655615302,0.0761576435023273,1.86037772126867,-4.38138716623394,0.916852090221585,"NET1","neuroepithelial cell transforming 1",TRUE
+"1562713_a_at",0.380817197915441,0.0119590878613775,2.73804702477539,-2.8283963575263,1.80460526099197,"NETO1","neuropilin and tolloid like 1",TRUE
+"1552904_at",0.685154158710982,0.153696089960675,1.47719919680899,-4.92931357734535,1.9066648278382,"NETO1","neuropilin and tolloid like 1",TRUE
+"236440_at",0.797508506396963,0.331078245375385,0.993741255689395,-5.46981441132902,0.527705402522929,"NETO1","neuropilin and tolloid like 1",TRUE
+"1552736_a_at",0.803583569469174,0.342114887122532,0.970825275187236,-5.49076482460808,0.853742121564101,"NETO1","neuropilin and tolloid like 1",TRUE
+"222774_s_at",0.962073096281571,0.827708392793577,-0.22023024432909,-5.91608782813757,-0.233615743367141,"NETO2","neuropilin and tolloid like 2",TRUE
+"218888_s_at",0.978072252406502,0.893816223570234,0.135018623326875,-5.93080820471797,0.161899193753991,"NETO2","neuropilin and tolloid like 2",TRUE
+"208926_at",0.961539013416204,0.825555561489278,-0.223029895723082,-5.91548482341348,-0.0867831090117814,"NEU1","neuraminidase 1 (lysosomal sialidase)",TRUE
+"221368_at",0.989475734766121,0.947977552580603,0.0659900716676646,-5.93756269458224,0.0421945030818791,"NEU2","neuraminidase 2",TRUE
+"216082_at",0.834650577370838,0.413166426365194,-0.834029078000001,-5.60644314993322,-0.373772537729948,"NEU3","neuraminidase 3",TRUE
+"216083_s_at",0.905934790589647,0.61234917750578,0.5139873506552,-5.81182242812867,0.336260340212,"NEU3","neuraminidase 3",TRUE
+"235474_at",0.947969282616012,0.763701017867486,-0.304350482509173,-5.89466763783291,-0.144064990564646,"NEU3","neuraminidase 3",TRUE
+"206948_at",0.97928472590149,0.899913016851975,0.127221015813748,-5.9318033463548,0.0391743085681684,"NEU3","neuraminidase 3",TRUE
+"222957_at",0.687949239097856,0.157181419715843,-1.46421025857692,-4.94615544963802,-0.768330512494549,"NEU4","neuraminidase 4",TRUE
+"204888_s_at",0.864549535575582,0.491855582844479,0.698950232909218,-5.70449857772757,0.432682427020887,"NEURL1","neuralized E3 ubiquitin protein ligase 1",TRUE
+"204889_s_at",0.956398858120188,0.802138445157734,0.25360595603953,-5.90840599837473,0.17012616101289,"NEURL1","neuralized E3 ubiquitin protein ligase 1",TRUE
+"225355_at",0.839466826665106,0.425876291643415,0.811205761470666,-5.62415336042939,0.636032971847207,"NEURL1B","neuralized E3 ubiquitin protein ligase 1B",TRUE
+"230283_at",0.757046717164774,0.252764294866812,-1.17424417001176,-5.28952488940535,-0.783137740675152,"NEURL2","neuralized E3 ubiquitin protein ligase 2",TRUE
+"232593_at",0.194325783329824,0.0020756517140305,3.48627694571411,-1.29988777463437,2.29490242020592,"NEURL3","neuralized E3 ubiquitin protein ligase 3",TRUE
+"226703_at",0.940044918888428,0.73131116453823,0.347748249750098,-5.88095452825057,0.07624456562157,"NEURL4","neuralized E3 ubiquitin protein ligase 4",TRUE
+"1556057_s_at",0.77547560202111,0.292708050490248,1.07782274692453,-5.38916727065141,0.730272795220828,"NEUROD1","neuronal differentiation 1",TRUE
+"206282_at",0.986421906591669,0.936188117618429,0.0809759096572723,-5.93649026467851,0.0580122592881982,"NEUROD1","neuronal differentiation 1",TRUE
+"210271_at",0.694024616341183,0.163402910487166,1.4415927963843,-4.97519361442939,1.03539790740243,"NEUROD2","neuronal differentiation 2",TRUE
+"1552953_a_at",0.790817398514927,0.320648512715488,1.01588758104001,-5.4491460739719,0.428754830353744,"NEUROD2","neuronal differentiation 2",TRUE
+"221318_at",0.8920930097751,0.563818067884389,-0.585969464306469,-5.77381505373218,-0.305367984036081,"NEUROD4","neuronal differentiation 4",TRUE
+"220045_at",0.955904644595647,0.800615929377681,0.255602185166439,-5.90791244297751,0.149898568134144,"NEUROD6","neuronal differentiation 6",TRUE
+"208497_x_at",0.990810941805126,0.956376989934154,-0.0553229863570529,-5.93819286929179,-0.0372051349852853,"NEUROG1","neurogenin 1",TRUE
+"215632_at",0.950214160603623,0.774147959905389,0.290483369238267,-5.89866817060624,0.142987874306219,"NEUROG2","neurogenin 2",TRUE
+"207965_at",0.804212866894346,0.342887811466873,0.969239525094448,-5.49219807511811,0.711462049035585,"NEUROG3","neurogenin 3",TRUE
+"226103_at",0.481025719247748,0.0272055005554105,2.36487488283745,-3.53059500453932,4.26207379115274,"NEXN","nexilin F-actin binding protein",TRUE
+"1552309_a_at",0.725168361556674,0.203577759233459,1.31011431055028,-5.13657363768122,1.3872153606093,"NEXN","nexilin F-actin binding protein",TRUE
+"1560746_at",0.736827856878244,0.222267980676596,1.25580636604058,-5.19943323454951,1.37301687477723,"NEXN-AS1","NEXN antisense RNA 1",TRUE
+"211095_at",0.670164229230396,0.136016203179461,1.54705150671444,-4.83669971695962,1.05171357844248,"NF1","neurofibromin 1",TRUE
+"204323_x_at",0.724067243569133,0.201321093262171,1.31692968381009,-5.12852570517231,0.39489151666923,"NF1P9///NF1","neurofibromin 1 pseudogene 9///neurofibromin 1",TRUE
+"204325_s_at",0.77204612088057,0.282312985478465,1.10194309620541,-5.36495046682591,0.414596544857075,"NF1P9///NF1","neurofibromin 1 pseudogene 9///neurofibromin 1",TRUE
+"216115_at",0.812302873476553,0.359414058952727,0.935900119160159,-5.52183456793019,0.441126901313202,"NF1P9///NF1","neurofibromin 1 pseudogene 9///neurofibromin 1",TRUE
+"243476_at",0.839519981963042,0.426618038569736,0.809887055954141,-5.62516255901657,0.342638997827769,"NF1P9///NF1","neurofibromin 1 pseudogene 9///neurofibromin 1",TRUE
+"211914_x_at",0.849646596450765,0.450943860766369,0.767401244038084,-5.65684954332771,0.44630003650653,"NF1P9///NF1","neurofibromin 1 pseudogene 9///neurofibromin 1",TRUE
+"210631_at",0.86632010667518,0.497223528272006,0.69021885782565,-5.71027189862208,0.370420335410456,"NF1P9///NF1","neurofibromin 1 pseudogene 9///neurofibromin 1",TRUE
+"212676_at",0.914910510855952,0.64175094653565,-0.471702861531243,-5.83188743133377,-0.176302718434673,"NF1P9///NF1","neurofibromin 1 pseudogene 9///neurofibromin 1",TRUE
+"211094_s_at",0.923376218980614,0.671134334971218,0.430299444055471,-5.84990021543025,0.191574059324354,"NF1P9///NF1","neurofibromin 1 pseudogene 9///neurofibromin 1",TRUE
+"212678_at",0.95825706371645,0.811179680677082,-0.241773013113559,-5.91125263684523,-0.0860684412935768,"NF1P9///NF1","neurofibromin 1 pseudogene 9///neurofibromin 1",TRUE
+"210767_at",0.500677386446044,0.0319460681327981,2.28936576169923,-3.66589488433519,0.750448656727711,"NF2","neurofibromin 2",TRUE
+"211092_s_at",0.641039907184506,0.111551243412429,1.65730511375304,-4.68371192272866,1.01536754799636,"NF2","neurofibromin 2",TRUE
+"204991_s_at",0.716472449896956,0.192324098382097,1.3447095709392,-5.09535824321725,1.15973749748354,"NF2","neurofibromin 2",TRUE
+"211091_s_at",0.722192678020526,0.198564912072513,1.32533491507648,-5.11855187019423,0.74644623016135,"NF2","neurofibromin 2",TRUE
+"238618_at",0.73223722457785,0.216106255339193,1.27330773306595,-5.17942376904331,0.501165366981135,"NF2","neurofibromin 2",TRUE
+"211017_s_at",0.740610299769501,0.230356144225817,1.2333879258874,-5.22471697469803,0.645108247642701,"NF2","neurofibromin 2",TRUE
+"217150_s_at",0.761748280722165,0.261156003043899,1.15310447756982,-5.31201444577364,0.496330174116176,"NF2","neurofibromin 2",TRUE
+"218915_at",0.886023097762234,0.548661801937557,0.609086927208707,-5.76058707783341,0.365655294565277,"NF2","neurofibromin 2",TRUE
+"243099_at",0.725583196024696,0.204434086299032,1.30754349635454,-5.13960021123221,0.389309353654481,"NFAM1","NFAT activating protein with ITAM motif 1",TRUE
+"230322_at",0.912246017248541,0.63227864241551,0.485226854689405,-5.82565294956584,0.131377093028704,"NFAM1","NFAT activating protein with ITAM motif 1",TRUE
+"213438_at",0.806216644294069,0.346671932370472,-0.961510938080745,-5.49915277794518,-1.13372840180676,"NFASC","neurofascin",TRUE
+"243645_at",0.884749233889577,0.544163139683219,0.616012953869681,-5.7565278048825,0.471719490932803,"NFASC","neurofascin",TRUE
+"230242_at",0.957813759927439,0.810379638234721,-0.242818641624233,-5.91100653706297,-0.109475724179556,"NFASC","neurofascin",TRUE
+"214799_at",0.999369827418759,0.99799917322034,-0.00253611234794714,-5.93968034802488,-0.00201937115337714,"NFASC","neurofascin",TRUE
+"208003_s_at",0.598294355283922,0.0754501980737566,1.86521119668057,-4.37388380681616,0.63739797928814,"NFAT5","nuclear factor of activated T-cells 5",TRUE
+"215092_s_at",0.661974206478491,0.129752300016565,1.57359845910724,-4.80061398033663,0.991886623725511,"NFAT5","nuclear factor of activated T-cells 5",TRUE
+"224984_at",0.741186481976394,0.231476001103908,1.23033139961616,-5.22813376861804,0.523561837745705,"NFAT5","nuclear factor of activated T-cells 5",TRUE
+"210162_s_at",0.559167054471987,0.0529236561194686,-2.0448913187503,-4.0854936310887,-1.1070362326706,"NFATC1","nuclear factor of activated T-cells 1",TRUE
+"208196_x_at",0.634202341398092,0.105272188542428,-1.68885916994288,-4.63844259426459,-1.19719545729855,"NFATC1","nuclear factor of activated T-cells 1",TRUE
+"209664_x_at",0.671298718565642,0.137380072587799,-1.54140563682812,-4.84431174789618,-1.14007346076234,"NFATC1","nuclear factor of activated T-cells 1",TRUE
+"210161_at",0.765934384067577,0.266213923553877,1.14060464875321,-5.3251435324007,0.75181847523252,"NFATC1","nuclear factor of activated T-cells 1",TRUE
+"211105_s_at",0.982844899319041,0.916461637717483,0.106095066792854,-5.93420250537792,0.103856286860142,"NFATC1","nuclear factor of activated T-cells 1",TRUE
+"231801_at",0.698961047987466,0.170320220253077,-1.41724601114298,-5.0060391670576,-1.28082597032566,"NFATC2","nuclear factor of activated T-cells 2",TRUE
+"228442_at",0.923708852928185,0.67240900084238,0.428521044473249,-5.85063756287297,0.627381246471368,"NFATC2","nuclear factor of activated T-cells 2",TRUE
+"226991_at",0.945498722604777,0.753613484482765,0.317798548766963,-5.8906114585439,0.455897956260531,"NFATC2","nuclear factor of activated T-cells 2",TRUE
+"224542_s_at",0.999500506744552,0.998515436295135,-0.00188173133503656,-5.93968175610117,-0.00125151334154117,"NFATC2","nuclear factor of activated T-cells 2",TRUE
+"229235_at",0.760337658876104,0.259046111641446,-1.15837159838688,-5.30644451313333,-0.353702025409204,"NFATC2IP","nuclear factor of activated T-cells 2 interacting protein",TRUE
+"217526_at",0.822173415758858,0.386420902842962,-0.883559599424554,-5.56643361285021,-0.275706531973466,"NFATC2IP","nuclear factor of activated T-cells 2 interacting protein",TRUE
+"212809_at",0.861285105384486,0.481516523861368,-0.715923205776466,-5.69307787273936,-0.196829556533377,"NFATC2IP","nuclear factor of activated T-cells 2 interacting protein",TRUE
+"217527_s_at",0.925511384407886,0.67744046720762,-0.421514828927933,-5.85351323190835,-0.135676181742475,"NFATC2IP","nuclear factor of activated T-cells 2 interacting protein",TRUE
+"212808_at",0.935869585112953,0.713862662041805,-0.371406563324423,-5.87271903835419,-0.114873623301401,"NFATC2IP","nuclear factor of activated T-cells 2 interacting protein",TRUE
+"238130_at",0.949179181265614,0.770589483761109,0.295200170489375,-5.89732817340339,0.148400839069728,"NFATC2IP","nuclear factor of activated T-cells 2 interacting protein",TRUE
+"225137_at",0.831957210365167,0.408157322119492,-0.843145716850403,-5.59924049285459,-0.218143661650572,"NFATC3","nuclear factor of activated T-cells 3",TRUE
+"210556_at",0.840728383233774,0.430007578971731,0.803879097659859,-5.62974090866529,0.330040557997971,"NFATC3","nuclear factor of activated T-cells 3",TRUE
+"207416_s_at",0.856631989847095,0.470756090104477,-0.733814635702851,-5.68075703467392,-0.297175848766416,"NFATC3","nuclear factor of activated T-cells 3",TRUE
+"210555_s_at",0.911633056109769,0.629993439169834,-0.488503224404623,-5.82411663671041,-0.185895435765158,"NFATC3","nuclear factor of activated T-cells 3",TRUE
+"225139_at",0.955904644595647,0.800278119889949,-0.256045243829092,-5.90780237797914,-0.0715185778343717,"NFATC3","nuclear factor of activated T-cells 3",TRUE
+"225141_at",0.997890350692744,0.990122470002941,-0.0125204150656829,-5.93960712863476,-0.00371584290367899,"NFATC3","nuclear factor of activated T-cells 3",TRUE
+"236270_at",0.64550640938897,0.116527631653756,1.63334465875369,-4.71765158446803,0.573602957027842,"NFATC4","nuclear factor of activated T-cells 4",TRUE
+"205897_at",0.885312914741353,0.546497274104909,0.612415610539637,-5.75864169545514,0.505634862897247,"NFATC4","nuclear factor of activated T-cells 4",TRUE
+"213345_at",0.937462538530338,0.722726520485579,-0.359361987055066,-5.87697864158057,-0.315649636641532,"NFATC4","nuclear factor of activated T-cells 4",TRUE
+"209930_s_at",0.77547560202111,0.2924383998718,1.07844057836653,-5.38855293472164,0.788452885595323,"NFE2","nuclear factor, erythroid 2",TRUE
+"214179_s_at",0.86376638668979,0.489412325436909,0.702942455928165,-5.70183579504375,0.253074570449849,"NFE2L1","nuclear factor, erythroid 2 like 1",TRUE
+"200759_x_at",0.92247975200053,0.668715302491774,0.433678339336876,-5.84849101889821,0.157276546432866,"NFE2L1","nuclear factor, erythroid 2 like 1",TRUE
+"200758_s_at",0.955904644595647,0.800586391512626,0.255640923870853,-5.90790282703359,0.0907241723649879,"NFE2L1","nuclear factor, erythroid 2 like 1",TRUE
+"201146_at",0.622917527985155,0.0936093728354422,1.7519731839041,-4.54597684760716,0.510333311638272,"NFE2L2","nuclear factor, erythroid 2 like 2",TRUE
+"1567013_at",0.642592458809121,0.112836164365391,1.65103361706388,-4.69263194901881,0.906594955981311,"NFE2L2","nuclear factor, erythroid 2 like 2",TRUE
+"1567015_at",0.934638969800115,0.709932444733403,-0.376764958669198,-5.87077949100577,-0.143207393175288,"NFE2L2","nuclear factor, erythroid 2 like 2",TRUE
+"1567014_s_at",0.891225909060826,0.560457621056029,0.591066902432718,-5.77094076997902,0.320028901607776,"NFE2L2///CSNK2A1","nuclear factor, erythroid 2 like 2///casein kinase 2 alpha 1",TRUE
+"236471_at",0.0605053655587832,0.000137222959840679,4.59973521395272,1.09398084097225,4.29206478244335,"NFE2L3","nuclear factor, erythroid 2 like 3",TRUE
+"204702_s_at",0.0863239677440823,0.000320990895517274,4.25299449980909,0.345712732601815,3.84704916294158,"NFE2L3","nuclear factor, erythroid 2 like 3",TRUE
+"1560527_at",0.623503825356688,0.0941335814526533,1.74899598673381,-4.55039524196502,1.44887351956822,"NFE4","nuclear factor, erythroid 4",TRUE
+"224970_at",0.858826390511142,0.475143935471708,-0.726490295305252,-5.68583584185776,-0.725965478294409,"NFIA","nuclear factor I A",TRUE
+"224975_at",0.862523912418014,0.485474364531357,-0.70940122022532,-5.69749724006355,-0.540025096982726,"NFIA","nuclear factor I A",TRUE
+"1558101_at",0.876829830808599,0.525841304478887,-0.644542324822012,-5.73934124017561,-0.585402183499626,"NFIA","nuclear factor I A",TRUE
+"1557639_at",0.914910510855952,0.641424768452798,0.472167063860486,-5.83167629428434,0.450352077481489,"NFIA","nuclear factor I A",TRUE
+"226806_s_at",0.930827859648584,0.693449454487199,-0.399362630901328,-5.86229868424957,-0.395173605181631,"NFIA","nuclear factor I A",TRUE
+"229994_at",0.937623890519979,0.723837783614809,-0.357855807900393,-5.87750155322406,-0.381108191623333,"NFIA","nuclear factor I A",TRUE
+"224976_at",0.941400961503247,0.73807674213791,-0.338629746505757,-5.88398571338047,-0.240148114839643,"NFIA","nuclear factor I A",TRUE
+"1556510_at",0.826140850652187,0.393986796493365,0.869329872746455,-5.57814780072983,0.454334139252012,"NFIA-AS2","NFIA antisense RNA 2",TRUE
+"1556511_a_at",0.897560972979555,0.584590432080633,0.554798245319449,-5.7908667564721,0.300199723484216,"NFIA-AS2","NFIA antisense RNA 2",TRUE
+"231364_at",0.976371465776674,0.886271234861079,-0.144680366475973,-5.92949321630437,-0.109268964820692,"NFIA-AS2","NFIA antisense RNA 2",TRUE
+"233304_at",0.47984873377716,0.0269588216341222,-2.36912760748925,-3.52290053174987,-2.3460488895316,"NFIB","nuclear factor I B",TRUE
+"211467_s_at",0.625623240781161,0.0968500248737402,-1.73379178103419,-4.57287270590583,-1.38472060864156,"NFIB","nuclear factor I B",TRUE
+"209289_at",0.652749978235988,0.121542298361212,-1.61005355123492,-4.75027831507413,-1.18104144323395,"NFIB","nuclear factor I B",TRUE
+"209290_s_at",0.68747436517451,0.156193399418832,-1.46786844044051,-4.94142431107134,-1.11696359764526,"NFIB","nuclear factor I B",TRUE
+"213029_at",0.715644762361881,0.191414522263926,-1.34757438191638,-5.0919047818896,-0.946653830147937,"NFIB","nuclear factor I B",TRUE
+"213033_s_at",0.744152356003007,0.234966669757097,-1.22087541466675,-5.23865794939365,-1.27621040170263,"NFIB","nuclear factor I B",TRUE
+"213032_at",0.768852835478002,0.273172910933929,-1.12368889348697,-5.34270984955902,-0.828184321248322,"NFIB","nuclear factor I B",TRUE
+"211466_at",0.875723781180194,0.523240689717512,-0.648635235530001,-5.73681426564068,-0.701614466894318,"NFIB","nuclear factor I B",TRUE
+"233394_at",0.903919439852106,0.605732905491996,0.52363210253622,-5.80701058360451,0.29933482663203,"NFIB","nuclear factor I B",TRUE
+"226895_at",0.592111379991983,0.0692237265283127,-1.90955055543925,-4.30441468178549,-0.777248518393742,"NFIC","nuclear factor I C",TRUE
+"226377_at",0.7346831595589,0.219282935177717,-1.26423776214102,-5.18982312571577,-0.561136746498629,"NFIC","nuclear factor I C",TRUE
+"213298_at",0.866213023333941,0.497072402507589,-0.69046393734203,-5.71011079333032,-0.269788997608703,"NFIC","nuclear factor I C",TRUE
+"206929_s_at",0.995810723090838,0.97987600858694,0.0255106699069544,-5.93936650782149,0.00871499042118096,"NFIC","nuclear factor I C",TRUE
+"203574_at",0.972752468205109,0.868102627912791,0.168006051346062,-5.92594496441996,0.102058181102814,"NFIL3","nuclear factor, interleukin 3 regulated",TRUE
+"229834_at",0.788413816943444,0.314642795453981,-1.02886882291329,-5.43683961458094,-0.388232977307077,"NFIX","nuclear factor I X",TRUE
+"228278_at",0.822010986888098,0.385412338139892,0.885470137422796,-5.564847387616,0.823672281176062,"NFIX","nuclear factor I X",TRUE
+"209807_s_at",0.955904644595647,0.800674042542733,0.255525971321691,-5.90793135698916,0.181530682901671,"NFIX","nuclear factor I X",TRUE
+"227400_at",0.981025273841474,0.910545762627038,-0.113641075567857,-5.9333953611465,-0.121258910012399,"NFIX","nuclear factor I X",TRUE
+"209239_at",0.874982802483487,0.521821019489329,0.650874254152406,-5.73542539036086,0.171663211539805,"NFKB1","nuclear factor kappa B subunit 1",TRUE
+"207535_s_at",0.433660982257499,0.0195950081528202,2.51628036687688,-3.25203624200447,1.11937356501118,"NFKB2","nuclear factor kappa B subunit 2",TRUE
+"209636_at",0.638134354959023,0.109437724028993,1.66775465314586,-4.66879218571434,1.35136589800999,"NFKB2","nuclear factor kappa B subunit 2",TRUE
+"211524_at",0.956619372543067,0.803127963274985,-0.252309125642677,-5.90872457099277,-0.163344611176889,"NFKB2","nuclear factor kappa B subunit 2",TRUE
+"231699_at",0.812302873476553,0.360351448023234,-0.93404036522369,-5.52345974538887,-0.505678088561657,"NFKBIA","NFKB inhibitor alpha",TRUE
+"201502_s_at",0.94895689004559,0.768885908832396,0.297460694478043,-5.89667839407899,0.130520913685309,"NFKBIA","NFKB inhibitor alpha",TRUE
+"214062_x_at",0.606900628956089,0.0804035353485554,1.83216366343353,-4.42490927858901,1.06074363875438,"NFKBIB","NFKB inhibitor beta",TRUE
+"214448_x_at",0.637176949657524,0.108089916928643,1.67450774940757,-4.65911228218335,0.497366301535424,"NFKBIB","NFKB inhibitor beta",TRUE
+"228388_at",0.968066640321622,0.849747073566868,-0.191669099722963,-5.92180604536833,-0.12663542158256,"NFKBIB","NFKB inhibitor beta",TRUE
+"1553042_a_at",0.904092974845832,0.606232436715134,0.522902173661275,-5.80737779890587,0.180808150746286,"NFKBID","NFKB inhibitor delta",TRUE
+"241889_at",0.913627134030439,0.637993305482984,0.477056981102119,-5.82943982694544,0.229360528871836,"NFKBID","NFKB inhibitor delta",TRUE
+"230052_s_at",0.931582451098271,0.697843549439656,-0.393318233931388,-5.86461479391839,-0.112873680716538,"NFKBID","NFKB inhibitor delta",TRUE
+"203927_at",0.806221445484273,0.346882748192054,0.961082067189299,-5.49953721462287,0.446510015644133,"NFKBIE","NFKB inhibitor epsilon",TRUE
+"209973_at",0.865545828022787,0.495423076140341,0.693141402697237,-5.70834717950802,0.241623527777179,"NFKBIL1","NFKB inhibitor like 1",TRUE
+"223217_s_at",0.585036027492332,0.0653968023796215,1.93857078036486,-4.2583330177152,1.2606481005117,"NFKBIZ","NFKB inhibitor zeta",TRUE
+"223218_s_at",0.65086850539757,0.120734585210654,1.61375003711421,-4.74512436510749,1.32376983161083,"NFKBIZ","NFKB inhibitor zeta",TRUE
+"237209_s_at",0.773107052530371,0.283742564756581,1.09858832220765,-5.36834721907188,0.61866050460537,"NFRKB","nuclear factor related to kappaB binding protein",TRUE
+"213028_at",0.803135302652907,0.341057168823841,0.972999289819471,-5.48879640737199,0.359157035534992,"NFRKB","nuclear factor related to kappaB binding protein",TRUE
+"206968_s_at",0.958798793150306,0.813633060919885,0.238568239720871,-5.91200033525566,0.0822515564044615,"NFRKB","nuclear factor related to kappaB binding protein",TRUE
+"237210_at",0.99783553534859,0.989455121054155,0.0133663744753721,-5.93959646244112,0.00809301024181242,"NFRKB","nuclear factor related to kappaB binding protein",TRUE
+"218455_at",0.770807031642694,0.279346163126715,-1.10894479763087,-5.35783151942397,-0.43903801392548,"NFS1","NFS1 cysteine desulfurase",TRUE
+"1554321_a_at",0.867692227847244,0.500563382401075,-0.684813414435362,-5.71381132453561,-0.26123387062473,"NFS1","NFS1 cysteine desulfurase",TRUE
+"218946_at",0.748184017928985,0.240668414740122,1.20565574888209,-5.25544925671816,0.402862310076337,"NFU1","NFU1 iron-sulfur cluster scaffold",TRUE
+"202585_s_at",0.642051176272454,0.112368147326938,-1.65331093392147,-4.68939587962437,-0.508820115074688,"NFX1","nuclear transcription factor, X-box binding 1",TRUE
+"202584_at",0.729083413548563,0.21071427197388,-1.28894057660987,-5.16135084793621,-0.486585236254735,"NFX1","nuclear transcription factor, X-box binding 1",TRUE
+"1553348_a_at",0.746259710622309,0.237984166701611,-1.2127865174043,-5.2476048607901,-0.449724402607043,"NFX1","nuclear transcription factor, X-box binding 1",TRUE
+"1553103_at",0.946913677125713,0.75887795288653,-0.310772989153431,-5.89275216602823,-0.0871879813512422,"NFX1","nuclear transcription factor, X-box binding 1",TRUE
+"210268_at",0.974536463688956,0.875569948687412,-0.158408366423071,-5.92746888852448,-0.0948824033189881,"NFX1","nuclear transcription factor, X-box binding 1",TRUE
+"227220_at",0.899002647214252,0.588959777239457,-0.548312703649879,-5.79430093810569,-0.169948285097451,"NFXL1","nuclear transcription factor, X-box binding like 1",TRUE
+"204108_at",0.842397669245069,0.436186641330079,-0.793001820592017,-5.63794839038956,-0.326132574235277,"NFYA","nuclear transcription factor Y subunit alpha",TRUE
+"228431_at",0.903919439852106,0.605622184604217,0.523793929955593,-5.80692910331123,0.442366414014683,"NFYA","nuclear transcription factor Y subunit alpha",TRUE
+"228433_at",0.943919772060845,0.748770639878692,0.324275876169226,-5.88859581585677,0.112616138527281,"NFYA","nuclear transcription factor Y subunit alpha",TRUE
+"204109_s_at",0.955645941042265,0.796993294548544,-0.260356248214304,-5.90672154756891,-0.0818322645374518,"NFYA","nuclear transcription factor Y subunit alpha",TRUE
+"204107_at",0.970526265934304,0.859307993262627,0.179330547652774,-5.92403192864922,0.069254292091383,"NFYA","nuclear transcription factor Y subunit alpha",TRUE
+"215720_s_at",0.986889306520757,0.938927303981552,-0.0774924971371761,-5.93675904742899,-0.0468776303853993,"NFYA","nuclear transcription factor Y subunit alpha",TRUE
+"218129_s_at",0.71520605704997,0.19090474982327,-1.34918464949821,-5.08996094076415,-0.453223355643019,"NFYB","nuclear transcription factor Y subunit beta",TRUE
+"218128_at",0.766438030219119,0.267051360864839,-1.13855197400003,-5.32728749453642,-0.418077366025754,"NFYB","nuclear transcription factor Y subunit beta",TRUE
+"244704_at",0.76711764189372,0.269034856576353,-1.13370895048714,-5.33233240195041,-0.498205902753351,"NFYB","nuclear transcription factor Y subunit beta",TRUE
+"218127_at",0.950887541143339,0.775637422582038,-0.288511071399597,-5.89922213379612,-0.0810273430122397,"NFYB","nuclear transcription factor Y subunit beta",TRUE
+"238231_at",0.774230543658252,0.290176131093988,1.08364014024365,-5.38337033865457,0.587592849101819,"NFYC","nuclear transcription factor Y subunit gamma",TRUE
+"202215_s_at",0.876884711883057,0.525986483967384,-0.644314164560736,-5.73948165483808,-0.185226861469873,"NFYC","nuclear transcription factor Y subunit gamma",TRUE
+"211797_s_at",0.94149227422279,0.738398409369131,-0.338196944503815,-5.88412760623395,-0.111431515110972,"NFYC","nuclear transcription factor Y subunit gamma",TRUE
+"1559218_s_at",0.942502815705589,0.742350038890078,0.332885384957796,-5.88585436561004,0.219147989984909,"NFYC","nuclear transcription factor Y subunit gamma",TRUE
+"211251_x_at",0.948429371744093,0.765117498588918,0.302466755197995,-5.89522192898593,0.0862895633719436,"NFYC","nuclear transcription factor Y subunit gamma",TRUE
+"202216_x_at",0.964181293782946,0.835436900915675,0.210194342758901,-5.91818710454927,0.0641153067577669,"NFYC","nuclear transcription factor Y subunit gamma",TRUE
+"1558782_a_at",0.64513208805899,0.116254832149191,1.63463563512918,-4.71583259731087,0.484721343896314,"NFYC-AS1","NFYC antisense RNA 1",TRUE
+"220337_at",0.870980161749509,0.511261770666461,0.667634270926986,-5.72488330700223,0.464480053394849,"NGB","neuroglobin",TRUE
+"236677_at",0.97424775926815,0.874390704984863,-0.159923002379182,-5.92723433447948,-0.0899900682969337,"NGB","neuroglobin",TRUE
+"213794_s_at",0.660460734341314,0.128505444060094,-1.57900900401842,-4.79320021114367,-0.46456776725201,"NGDN","neuroguidin",TRUE
+"216263_s_at",0.984916798133038,0.925776755183413,0.0942257498276948,-5.93536001970565,0.0490325636955191,"NGDN","neuroguidin",TRUE
+"243556_at",0.702621412021935,0.174065057628479,1.40439440896317,-5.0221471439054,0.900801743973379,"NGEF","neuronal guanine nucleotide exchange factor",TRUE
+"227240_at",0.975159323713639,0.879029325900802,0.153967271517324,-5.92814379249596,0.122778464432935,"NGEF","neuronal guanine nucleotide exchange factor",TRUE
+"206814_at",0.909891927025433,0.624894635450271,0.495833202051394,-5.82064298256458,0.491268954276099,"NGF","nerve growth factor",TRUE
+"205858_at",0.940044918888428,0.730738516123338,-0.348521423686698,-5.88069384720566,-0.344655774550906,"NGFR","nerve growth factor receptor",TRUE
+"220742_s_at",0.911730272337063,0.630900950615095,-0.487201448762888,-5.82472825829677,-0.145500872477426,"NGLY1","N-glycanase 1",TRUE
+"207492_at",0.97689149311934,0.88959780410773,-0.14041884220392,-5.93008439797942,-0.116441632694497,"NGLY1","N-glycanase 1",TRUE
+"228541_x_at",0.813065886130395,0.362712962328738,0.929369522704071,-5.52752833700905,0.283472187701985,"NGRN","neugrin, neurite outgrowth associated",TRUE
+"224281_s_at",0.880842449447422,0.536720237680102,-0.627539116914776,-5.74967440118465,-0.202786365414633,"NGRN","neugrin, neurite outgrowth associated",TRUE
+"217722_s_at",0.901047404714435,0.597352817168434,-0.535920771152781,-5.80075350438215,-0.182187409416249,"NGRN","neugrin, neurite outgrowth associated",TRUE
+"1568974_at",0.528328646587879,0.0409102088198697,2.17105071467501,-3.87263685285847,1.17416142721742,"NHEG1","neuroblastoma highly expressed 1",TRUE
+"214628_at",0.933298127911264,0.704859457337242,0.383698061732538,-5.86822929442907,0.152941502211656,"NHLH1","nescient helix-loop-helix 1",TRUE
+"215228_at",0.902424542997102,0.601362918573105,0.530030002816279,-5.80377056162136,0.382514163854758,"NHLH2","nescient helix-loop-helix 2",TRUE
+"214497_s_at",0.924043155603915,0.673254378539325,0.427342357637967,-5.85112460851422,0.172027395578547,"NHLH2","nescient helix-loop-helix 2",TRUE
+"219353_at",0.640067422642767,0.110543483082642,1.66226658956776,-4.67663688474711,0.714104608636873,"NHLRC2","NHL repeat containing 2",TRUE
+"236185_at",0.688047719328924,0.157354342615251,1.46357192177047,-4.94698003242165,0.676322765774856,"NHLRC2","NHL repeat containing 2",TRUE
+"244320_at",0.774602575059788,0.290984221109337,1.08177950574236,-5.38522745842497,0.39270980383125,"NHLRC2","NHL repeat containing 2",TRUE
+"235356_at",0.86481525165637,0.492521013179469,0.697864909409485,-5.70521997953643,0.300271738577843,"NHLRC2","NHL repeat containing 2",TRUE
+"227040_at",0.947620464753301,0.761112118686355,0.307796279579541,-5.89364487873707,0.173124293276397,"NHLRC3","NHL repeat containing 3",TRUE
+"236953_s_at",0.975398143273847,0.880999091879281,-0.151439938141956,-5.92851931776567,-0.0807963996313319,"NHLRC3","NHL repeat containing 3",TRUE
+"239314_at",0.9882620262439,0.944167588533047,-0.0708311469300204,-5.93724015541021,-0.0250137753537665,"NHLRC3","NHL repeat containing 3",TRUE
+"1558431_at",0.860085676417428,0.478783678453699,0.720444773025521,-5.68999142102045,0.237821022983926,"NHLRC4","NHL repeat containing 4",TRUE
+"209104_s_at",0.934048461921637,0.707944250241705,-0.379479906277999,-5.8697863171446,-0.128483535094023,"NHP2","NHP2 ribonucleoprotein",TRUE
+"242800_at",0.686108994812404,0.154776115465237,1.47314888411995,-4.9345782481303,1.44634397010057,"NHS","NHS actin remodeling regulator",TRUE
+"228933_at",0.687734660055697,0.156811482638599,1.4655777764428,-4.94438795365034,1.88035578479275,"NHS","NHS actin remodeling regulator",TRUE
+"234324_at",0.640067422642767,0.110483818102283,1.66256153114116,-4.67621579233917,0.784964846134894,"NHSL1","NHS like 1",TRUE
+"234321_x_at",0.660093442228076,0.128131169682059,1.5806416163681,-4.79095922138353,0.785845453530579,"NHSL1","NHS like 1",TRUE
+"231034_s_at",0.702809964629668,0.174550789579304,1.40274369235467,-5.02420736227871,1.4240716813418,"NHSL1","NHS like 1",TRUE
+"226490_at",0.727318639756418,0.207759716794069,1.29763812295073,-5.15121454211986,0.986428453839794,"NHSL1","NHS like 1",TRUE
+"234922_s_at",0.919375181609246,0.657256057634686,-0.449755341927509,-5.84163778520646,-0.26831041665,"NHSL1","NHS like 1",TRUE
+"227618_at",0.767011398042819,0.268341458665681,1.13539900316579,-5.33057405337728,1.07857915552743,"NHSL2","NHS like 2",TRUE
+"1569932_at",0.97368753448323,0.873353642041007,-0.161255335988314,-5.92702617080591,-0.0794409636249593,"NHSL2","NHS like 2",TRUE
+"223442_at",0.89390639630277,0.569643294251003,-0.577170100512098,-5.77872004669871,-0.213497754885637,"NICN1","nicolin 1",TRUE
+"202007_at",0.193335085181883,0.00199877104225971,3.50197360701747,-1.26668449765703,7.03728129186895,"NID1","nidogen 1",TRUE
+"202008_s_at",0.387357699611418,0.0128226054742422,2.70712134613042,-2.88848873022246,2.37014549309053,"NID1","nidogen 1",TRUE
+"1561082_at",0.870517518639056,0.509476849053068,0.670486315844459,-5.72306379726821,0.24059661759448,"NID1","nidogen 1",TRUE
+"204114_at",0.319095917986488,0.00699039794683961,2.97267770045118,-2.36310734010847,4.27503311812699,"NID2","nidogen 2",TRUE
+"218133_s_at",0.888232641270866,0.553920433688095,-0.601028737820793,-5.7652541537619,-0.185326525090447,"NIF3L1","NGG1 interacting factor 3 like 1",TRUE
+"234167_at",0.642592458809121,0.112993199300177,1.65027128558829,-4.69371446117806,0.850599935572043,"NIFK","nucleolar protein interacting with the FHA domain of MKI67",TRUE
+"224713_at",0.734203380012717,0.2185891654293,-1.26620993846568,-5.18756729515861,-0.390218907680518,"NIFK","nucleolar protein interacting with the FHA domain of MKI67",TRUE
+"224714_at",0.82847108093969,0.398524153926889,-0.860880869137366,-5.58501954100978,-0.291945763703609,"NIFK","nucleolar protein interacting with the FHA domain of MKI67",TRUE
+"235132_at",0.778481681746654,0.298518143245832,-1.06460843801388,-5.40223142481614,-0.419088862028722,"NIFK-AS1","NIFK antisense RNA 1",TRUE
+"1557059_at",0.822173415758858,0.386556563048472,0.883302864826708,-5.56664652479142,0.343019108179741,"NIFK-AS1","NIFK antisense RNA 1",TRUE
+"230864_at",0.975398143273847,0.882074754839547,0.150060222346187,-5.92872170678837,0.0983437850737152,"NIM1K","NIM1 serine/threonine protein kinase",TRUE
+"223981_at",0.84772210282622,0.446831585802568,0.774483152825018,-5.65167943022035,0.551809806038924,"NIN","ninein",TRUE
+"225921_at",0.917324269491721,0.650155148917671,0.459778206976634,-5.83724150765843,0.22102485815228,"NIN","ninein",TRUE
+"219285_s_at",0.930499673921727,0.692492717077331,-0.400680694453449,-5.86178900512463,-0.26004268344805,"NIN","ninein",TRUE
+"224303_x_at",0.968035667633768,0.84929909785617,-0.192247953170093,-5.92169799641676,-0.0627557726699797,"NIN","ninein",TRUE
+"224304_x_at",0.969882914559333,0.857322905419233,-0.181889934671032,-5.92358234428186,-0.0680307485414104,"NIN","ninein",TRUE
+"234299_s_at",0.989032420373543,0.946830085911148,0.0674479079974873,-5.9374679661608,0.0504900445035759,"NIN","ninein",TRUE
+"203045_at",0.717994416213789,0.193939204288074,-1.33964873571939,-5.10144390129797,-0.774375131495221,"NINJ1","ninjurin 1",TRUE
+"219594_at",0.555307820043702,0.0514576664974489,2.05881818316222,-4.06240002270826,2.08425570858577,"NINJ2","ninjurin 2",TRUE
+"207705_s_at",0.87754354850942,0.527798624985548,0.641469139260784,-5.74122853236704,0.36383032916798,"NINL","ninein like",TRUE
+"223397_s_at",0.917654257398946,0.650693882568825,-0.459016123926754,-5.83757911181874,-0.193109703681325,"NIP7","NIP7, nucleolar pre-rRNA processing protein",TRUE
+"219031_s_at",0.948684674264832,0.766685064858268,0.300383405676225,-5.8958309868198,0.110796031963323,"NIP7","NIP7, nucleolar pre-rRNA processing protein",TRUE
+"225752_at",0.512681169570718,0.0342771217285511,2.25593874127879,-3.72497165962779,0.772928060758188,"NIPA1","non imprinted in Prader-Willi/Angelman syndrome 1",TRUE
+"1552696_at",0.661974206478491,0.129716877807317,1.57375157177372,-4.80040445268443,0.554521812504946,"NIPA1","non imprinted in Prader-Willi/Angelman syndrome 1",TRUE
+"212129_at",0.498396792791655,0.0312210682193808,2.30021795144241,-3.64660573553318,0.741594263928588,"NIPA2","non imprinted in Prader-Willi/Angelman syndrome 2",TRUE
+"212133_at",0.528768444275307,0.0411811769350241,2.16785593072338,-3.87812633686033,0.663565131590129,"NIPA2","non imprinted in Prader-Willi/Angelman syndrome 2",TRUE
+"220128_s_at",0.672164152353115,0.13798082745119,-1.53893339975785,-4.84763799877508,-1.28421861621323,"NIPAL2","NIPA like domain containing 2",TRUE
+"227001_at",0.842224301155785,0.435809377663084,-0.793663195930227,-5.63745235030916,-0.809505833468011,"NIPAL2","NIPA like domain containing 2",TRUE
+"222950_at",0.950566549545106,0.774883422281214,-0.289509347431396,-5.89894221392414,-0.181351397356469,"NIPAL2","NIPA like domain containing 2",TRUE
+"225875_s_at",0.774852179746145,0.291300226247527,1.08105291137581,-5.3859519069217,0.626743877446659,"NIPAL3","NIPA like domain containing 3",TRUE
+"214579_at",0.827825169467994,0.396885605912609,-0.863924811681626,-5.58255103667135,-0.692464324758865,"NIPAL3","NIPA like domain containing 3",TRUE
+"229735_s_at",0.863234351965993,0.487342565013888,0.706333375751713,-5.69956272238059,0.286047283708079,"NIPAL3","NIPA like domain containing 3",TRUE
+"225876_at",0.906845308365483,0.61497914491495,0.510167286818662,-5.81370418121628,0.323600191683848,"NIPAL3","NIPA like domain containing 3",TRUE
+"210267_at",0.978257169730337,0.895177238905161,0.133277201426835,-5.9310355712845,0.09453302053966,"NIPAL3","NIPA like domain containing 3",TRUE
+"230188_at",0.967855347887867,0.848650264894234,-0.193086464289092,-5.92154090391411,-0.163104145663061,"NIPAL4","NIPA like domain containing 4",TRUE
+"242352_at",0.497725944448536,0.0305977061434666,2.30973504183022,-3.62964594442958,0.947173106963568,"NIPBL","NIPBL, cohesin loading factor",TRUE
+"212469_at",0.528412182286162,0.0410299587925763,2.16963647725776,-3.87506750625765,0.747350597406006,"NIPBL","NIPBL, cohesin loading factor",TRUE
+"207108_s_at",0.565043084457947,0.0564095677818872,2.01310922736209,-4.13780728892926,0.753838056427776,"NIPBL","NIPBL, cohesin loading factor",TRUE
+"212483_at",0.598618215299661,0.0755786289933893,1.86433079166196,-4.37525155091375,0.876232173809258,"NIPBL","NIPBL, cohesin loading factor",TRUE
+"213918_s_at",0.731054546207485,0.21373611598289,1.28014193259282,-5.17154596267586,0.435277218932725,"NIPBL","NIPBL, cohesin loading factor",TRUE
+"201708_s_at",0.649220725475646,0.119924367082866,-1.6174788213467,-4.73991611843034,-0.603519738452936,"NIPSNAP1","nipsnap homolog 1 (C. elegans)",TRUE
+"201709_s_at",0.714234994916485,0.18924777999735,-1.35444216107187,-5.08360079249662,-0.451875488369966,"NIPSNAP1","nipsnap homolog 1 (C. elegans)",TRUE
+"224436_s_at",0.962125056232529,0.827941221381832,-0.219927570431125,-5.91615256562169,-0.0925367042802847,"NIPSNAP3A","nipsnap homolog 3A",TRUE
+"223764_x_at",0.780869091890715,0.302621585515727,1.05538593894517,-5.41126357650334,0.999921825391899,"NIPSNAP3B","nipsnap homolog 3B",TRUE
+"221104_s_at",0.879419229950485,0.533669119128295,0.632288880004814,-5.74681462793059,0.27854722962884,"NIPSNAP3B","nipsnap homolog 3B",TRUE
+"227392_at",0.540483367247649,0.0450476946419302,-2.1242248458117,-3.95258863567721,-1.41125351685428,"NISCH","nischarin",TRUE
+"201591_s_at",0.7994347047598,0.334665328764598,-0.986236313102392,-5.47672462924767,-0.360228376357922,"NISCH","nischarin",TRUE
+"202891_at",0.817857130700434,0.370671507628118,-0.91377629149293,-5.54097499917485,-0.343171841010802,"NIT1","nitrilase 1",TRUE
+"241395_at",0.961395512423249,0.82492436780535,-0.223851076798988,-5.91530651489985,-0.159980413637785,"NIT1","nitrilase 1",TRUE
+"218557_at",0.96991997520441,0.857556497875746,0.181588698137833,-5.92363558953293,0.0576872510340785,"NIT2","nitrilase family member 2",TRUE
+"219438_at",0.804966190665093,0.344075234883044,-0.966808128298723,-5.49439149288966,-1.23364753433608,"NKAIN1","Na+/K+ transporting ATPase interacting 1",TRUE
+"1554601_at",0.814143616628706,0.365113470731148,-0.924642365248719,-5.5316268794173,-0.575789817341419,"NKAIN2","Na+/K+ transporting ATPase interacting 2",TRUE
+"242002_at",0.942502815705589,0.742457756447492,-0.33274073439108,-5.88590101248917,-0.360099022916847,"NKAIN2","Na+/K+ transporting ATPase interacting 2",TRUE
+"1553241_at",0.709158363400091,0.181841793114027,-1.37839494335005,-5.05436352703308,-0.706635605255165,"NKAIN3","Na+/K+ transporting ATPase interacting 3",TRUE
+"228018_at",0.682381152782224,0.149832372729177,1.49188104757669,-4.91013218353713,0.784973389414999,"NKAIN4","Na+/K+ transporting ATPase interacting 4",TRUE
+"230668_at",0.91539387234353,0.643310133835058,0.469485344703191,-5.83289323813697,0.179905256620579,"NKAIN4","Na+/K+ transporting ATPase interacting 4",TRUE
+"228017_s_at",0.937232018318296,0.72148855257766,0.361040897042785,-5.87639320528494,0.251319194472285,"NKAIN4","Na+/K+ transporting ATPase interacting 4",TRUE
+"230771_at",0.968917934155285,0.853176266260359,-0.187240259469016,-5.92262198821222,-0.140524608343923,"NKAIN4","Na+/K+ transporting ATPase interacting 4",TRUE
+"223439_at",0.603702127972549,0.0778574307138328,-1.84892225928482,-4.39911512601565,-0.593239670656992,"NKAP","NFKB activating protein",TRUE
+"230804_at",0.728385463227073,0.209372982647099,1.29287725265104,-5.15677013503977,1.29821983407462,"NKAPL","NFKB activating protein like",TRUE
+"229340_at",0.739158983353674,0.225756120037,1.24606303274715,-5.21046996773718,0.74639145393149,"NKAPL","NFKB activating protein like",TRUE
+"236493_at",0.740039310225527,0.228447800237521,1.23862266020087,-5.21884825846274,0.817333180641546,"NKAPP1","NFKB activating protein pseudogene 1",TRUE
+"229481_at",0.774230543658252,0.288876030342113,1.0866414726742,-5.38036867622771,0.71732442699779,"NKD1","naked cuticle homolog 1",TRUE
+"232203_at",0.847311733573803,0.445993267219437,0.77593170556446,-5.65061639968612,0.359350492758263,"NKD1","naked cuticle homolog 1",TRUE
+"1553115_at",0.873230718105642,0.517865148440999,-0.657130962538756,-5.73151997320515,-0.356371171282829,"NKD1","naked cuticle homolog 1",TRUE
+"232201_at",0.96395433907282,0.835015001307275,-0.21074162411435,-5.91807513870316,-0.139362536376419,"NKD2","naked cuticle homolog 2",TRUE
+"213915_at",0.976162707906163,0.885339851113869,-0.145874010280264,-5.92932446551087,-0.0691543063450322,"NKG7","natural killer cell granule protein 7",TRUE
+"225930_at",0.740873970985555,0.231185200164327,-1.23112402760534,-5.22724841722419,-0.432648141895344,"NKIRAS1","NFKB inhibitor interacting Ras like 1",TRUE
+"218240_at",0.79782885150643,0.331507936304822,-0.99283930040097,-5.4706474093503,-0.324116510444917,"NKIRAS2","NFKB inhibitor interacting Ras like 2",TRUE
+"222105_s_at",0.9116561917482,0.630327606590929,-0.488023780024247,-5.82434208267154,-0.189481391380324,"NKIRAS2","NFKB inhibitor interacting Ras like 2",TRUE
+"1560430_at",0.821745015752602,0.384466142776296,-0.887265499201589,-5.56335389350229,-0.253683822410216,"NKPD1","NTPase, KAP family P-loop domain containing 1",TRUE
+"205004_at",0.844472871821284,0.441216944404868,-0.784216685533541,-5.64450041955181,-0.281860508509997,"NKRF","NFKB repressing factor",TRUE
+"215338_s_at",0.766550448794594,0.267324885084043,1.13788255354639,-5.32798594961061,0.324188662723628,"NKTR","natural killer cell triggering receptor",TRUE
+"202379_s_at",0.801086839730802,0.337354965449295,0.980645301580844,-5.48184159610223,0.336723293715567,"NKTR","natural killer cell triggering receptor",TRUE
+"1570342_at",0.828607509614823,0.399182953823483,0.859659283348457,-5.58600791351431,0.509120966134669,"NKTR","natural killer cell triggering receptor",TRUE
+"215339_at",0.874834820370747,0.521628141094914,-0.651178708485789,-5.73523618087562,-0.479760957158548,"NKTR","natural killer cell triggering receptor",TRUE
+"1557737_s_at",0.895690630367785,0.575941474962294,0.567707777199499,-5.78391437826952,0.393875067684665,"NKTR","natural killer cell triggering receptor",TRUE
+"231235_at",0.89657270599571,0.581233053618333,0.559798076832381,-5.7881925231559,0.477159319755602,"NKTR","natural killer cell triggering receptor",TRUE
+"1557736_at",0.906507435035949,0.614166524407469,0.511346805866202,-5.81312461397918,0.27478784713718,"NKTR","natural killer cell triggering receptor",TRUE
+"202380_s_at",0.939976205834042,0.730256496161052,-0.349172401497346,-5.88047392175132,-0.115917024875651,"NKTR","natural killer cell triggering receptor",TRUE
+"1565537_at",0.863496154094018,0.48824844268526,0.704848243260758,-5.700559550779,0.280914263556235,"NKX1-1","NK1 homeobox 1",TRUE
+"210673_x_at",0.904092974845832,0.606152643307569,0.523018750689978,-5.80731918438173,0.39202993268232,"NKX2-1","NK2 homeobox 1",TRUE
+"211024_s_at",0.934447550624693,0.709377401246533,-0.377522598531406,-5.87050304102551,-0.38895254730541,"NKX2-1","NK2 homeobox 1",TRUE
+"236579_at",0.7768734672127,0.294395259876858,-1.07396620321237,-5.39299488460437,-0.594769425065148,"NKX2-1-AS1","NKX2-1 antisense RNA 1",TRUE
+"206915_at",0.900831880406409,0.596621705398648,0.536996826499793,-5.80019888050784,1.00325459537624,"NKX2-2","NK2 homeobox 2",TRUE
+"1553808_a_at",0.598790786356002,0.0756905261406932,1.86356478986754,-4.37644119326523,1.55578824461141,"NKX2-3","NK2 homeobox 3",TRUE
+"206578_at",0.920389295526597,0.66123258396497,-0.444162950476846,-5.84404944670985,-0.405012339127231,"NKX2-5","NK2 homeobox 5",TRUE
+"207451_at",0.921715898833969,0.665843856538551,0.437695839028388,-5.846801402424,0.400209009367605,"NKX2-8","NK2 homeobox 8",TRUE
+"209706_at",0.603702127972549,0.0777655613562775,1.84953580630084,-4.39816760141424,1.22883924980906,"NKX3-1","NK3 homeobox 1",TRUE
+"211498_s_at",0.608709711882903,0.0814284925964618,1.82554718417874,-4.43504678569337,0.56058350285041,"NKX3-1","NK3 homeobox 1",TRUE
+"211497_x_at",0.744573608322482,0.235673158357297,1.21897454704708,-5.24076507461837,0.391718602029965,"NKX3-1","NK3 homeobox 1",TRUE
+"207031_at",0.936143408699214,0.714740570215534,0.370211154852834,-5.87314799344189,0.283416538406338,"NKX3-2","NK3 homeobox 2",TRUE
+"221366_at",0.981587171772385,0.912545632062899,0.111089403330227,-5.93367449201335,0.0724512915770568,"NKX6-1","NK6 homeobox 1",TRUE
+"235832_at",0.883952384679702,0.542508085704188,-0.618568675236847,-5.75501874664754,-0.635793537445043,"NKX6-2","NK6 homeobox 2",TRUE
+"1552884_at",0.859465912277024,0.476655343934928,0.723976604308032,-5.68756771535968,0.200535493665425,"NKX6-3","NK6 homeobox 3",TRUE
+"1552885_a_at",0.864894115958506,0.493165462096439,-0.69681460753197,-5.70591708456807,-0.336176840440112,"NKX6-3","NK6 homeobox 3",TRUE
+"203867_s_at",0.851733415458562,0.456614237593395,0.757699821805847,-5.66385916434186,0.36430926176606,"NLE1","notchless homolog 1",TRUE
+"203866_at",0.932269331146744,0.701406446863422,0.388428145720626,-5.86646312559232,0.133829335648641,"NLE1","notchless homolog 1",TRUE
+"205893_at",0.746259710622309,0.237882017440407,1.21305907475359,-5.24730423100482,1.19471600724398,"NLGN1","neuroligin 1",TRUE
+"231361_at",0.89732810490777,0.583644848042617,0.55620496466015,-5.79011670595471,0.549261103598658,"NLGN1","neuroligin 1",TRUE
+"235838_at",0.617775129514679,0.0888571476514331,1.77963642168475,-4.50465843071506,0.869857558746189,"NLGN2","neuroligin 2",TRUE
+"1554428_s_at",0.778397054392363,0.298205321670399,1.06531520371327,-5.40153634123733,0.290591078016968,"NLGN2","neuroligin 2",TRUE
+"226288_s_at",0.813631136157676,0.3642606077594,0.926319464738935,-5.53017500084248,0.341520377987798,"NLGN2","neuroligin 2",TRUE
+"219726_at",0.731548533938014,0.215256567242703,1.27575110536959,-5.17661141669311,0.869531245194522,"NLGN3","neuroligin 3",TRUE
+"234751_s_at",0.786851686785014,0.312754471238897,-1.03298630110704,-5.43290670726431,-0.524725094217577,"NLGN3","neuroligin 3",TRUE
+"1554689_a_at",0.854184492233394,0.46397056210048,-0.745221093387548,-5.67275137606592,-0.769774455089747,"NLGN4X","neuroligin 4, X-linked",TRUE
+"221933_at",0.997039490727282,0.984843297953014,-0.0192128214833582,-5.93950369151289,-0.0327993472719026,"NLGN4X","neuroligin 4, X-linked",TRUE
+"207703_at",0.456898036702485,0.0224076060759493,2.45482818631213,-3.3662193415537,1.56450019778643,"NLGN4Y","neuroligin 4, Y-linked",TRUE
+"1554125_a_at",0.654592482818544,0.123488943327618,1.60122837645358,-4.76254604563744,1.26968173930352,"NLGN4Y","neuroligin 4, Y-linked",TRUE
+"218318_s_at",0.646692716816097,0.117735843629772,-1.62765731557617,-4.72565189093607,-0.879717231931614,"NLK","nemo like kinase",TRUE
+"222589_at",0.899798994481376,0.591576955422669,-0.54443932817775,-5.7963332328992,-0.358011121026408,"NLK","nemo like kinase",TRUE
+"222590_s_at",0.908013878860707,0.618419311136135,-0.505181970502252,-5.81613934153543,-0.20435973836806,"NLK","nemo like kinase",TRUE
+"224063_at",0.771534633613556,0.280849335159001,1.10539060302374,-5.36145023413543,0.795952675331776,"NLN","neurolysin",TRUE
+"225943_at",0.843035902046504,0.436998478318455,0.791579795238841,-5.63901360998972,0.241331658696291,"NLN","neurolysin",TRUE
+"225942_at",0.920780424288498,0.663072886648569,0.441579712602561,-5.8451534454046,0.166194784639017,"NLN","neurolysin",TRUE
+"228797_at",0.95194340202313,0.780308869766705,0.282332826038584,-5.90093319373784,0.0725161012307947,"NLN","neurolysin",TRUE
+"225944_at",0.971352228387114,0.863919775893678,0.173389244054319,-5.92505109719682,0.0635416531552355,"NLN","neurolysin",TRUE
+"234762_x_at",0.993615552413264,0.969803713630552,0.0382844940166743,-5.93896961632511,0.0126365571067435,"NLN","neurolysin",TRUE
+"236295_s_at",0.89967769475675,0.591099696618924,0.545145032953191,-5.7959640044127,0.497307937402786,"NLRC3","NLR family CARD domain containing 3",TRUE
+"1552553_a_at",0.772704859424721,0.28324738532401,-1.09974896455115,-5.36717309535347,-0.58577515808116,"NLRC4","NLR family CARD domain containing 4",TRUE
+"1552554_a_at",0.977063818674184,0.890669250147846,0.139046829564506,-5.93027097720301,0.106313169278653,"NLRC4","NLR family CARD domain containing 4",TRUE
+"226474_at",0.280199223932988,0.00460989314835109,3.15098009272333,-1.99991685705365,1.7527948569932,"NLRC5","NLR family CARD domain containing 5",TRUE
+"210113_s_at",0.0349782613500075,3.71054258491164e-05,5.1364207449174,2.23980165253267,4.22946057292757,"NLRP1","NLR family pyrin domain containing 1",TRUE
+"211822_s_at",0.071020853517731,0.000205236302803868,4.43542598571112,0.73978306312352,3.48183861724763,"NLRP1","NLR family pyrin domain containing 1",TRUE
+"211824_x_at",0.158614506070125,0.00124454729042677,3.69806476281051,-0.849452204681485,3.63869953647646,"NLRP1","NLR family pyrin domain containing 1",TRUE
+"1562257_x_at",0.767727587789514,0.270186689173619,1.13090858138896,-5.33524084615607,0.308741958030678,"NLRP1","NLR family pyrin domain containing 1",TRUE
+"1562256_at",0.948429371744093,0.765251710499901,-0.302288329585005,-5.89527425429131,-0.0908829648183431,"NLRP1","NLR family pyrin domain containing 1",TRUE
+"1553534_at",0.722362743674536,0.198852369963618,1.32445404677843,-5.1195996372884,1.2467746483568,"NLRP10","NLR family pyrin domain containing 10",TRUE
+"1552531_a_at",0.835952408568777,0.417110452937279,0.826900033465049,-5.61202448246577,0.616660714047355,"NLRP11","NLR family pyrin domain containing 11",TRUE
+"223944_at",0.812302873476553,0.360538687251319,0.933669276893183,-5.52378367173444,0.454480940780133,"NLRP12","NLR family pyrin domain containing 12",TRUE
+"1554952_s_at",0.972278576610345,0.866577180005463,0.16996865531531,-5.92562233445317,0.127002543725526,"NLRP12","NLR family pyrin domain containing 12",TRUE
+"1553525_at",0.841550580403629,0.433094576026031,-0.798432923909803,-5.63386347539465,-0.451721518824529,"NLRP13","NLR family pyrin domain containing 13",TRUE
+"1553523_at",0.937113154905832,0.719946318125911,-0.36313392868597,-5.87565959123454,-0.198202304164676,"NLRP14","NLR family pyrin domain containing 14",TRUE
+"221690_s_at",0.797960028258877,0.332004646866745,0.991797671668354,-5.47160854697927,2.01674832846144,"NLRP2","NLR family pyrin domain containing 2",TRUE
+"237489_at",0.941106542715586,0.735989495390166,0.341439736149261,-5.88306010167928,0.344227134339314,"NLRP2","NLR family pyrin domain containing 2",TRUE
+"234653_at",0.821424121108148,0.383337160157113,0.889411475384524,-5.5615650593221,0.853339079733086,"NLRP2B","NLR family pyrin domain containing 2B",TRUE
+"216015_s_at",0.354491656197816,0.00949201252260818,2.83973441163063,-2.62869400572023,1.53910035091703,"NLRP3","NLR family pyrin domain containing 3",TRUE
+"207075_at",0.358427723880268,0.0101304638042229,2.81120268781561,-2.68504367753709,2.34494944964827,"NLRP3","NLR family pyrin domain containing 3",TRUE
+"216016_at",0.789860910391852,0.318891444645446,1.01966770263831,-5.44557702192872,0.946688849858098,"NLRP3","NLR family pyrin domain containing 3",TRUE
+"242334_at",0.700061364939874,0.171437683844168,1.41338762114505,-5.01088788776539,0.527054254983586,"NLRP4","NLR family pyrin domain containing 4",TRUE
+"1552405_at",0.999183994994247,0.99735649797551,-0.00335072670681345,-5.93967801231287,-0.0011365255785627,"NLRP5","NLR family pyrin domain containing 5",TRUE
+"1552932_at",0.840879524142924,0.430408390978905,0.803170606935292,-5.63027870182666,0.576875063342239,"NLRP6","NLR family pyrin domain containing 6",TRUE
+"237461_at",0.94630837494651,0.756972607372361,0.313313857089908,-5.8919834280923,0.272108493917285,"NLRP7","NLR family pyrin domain containing 7",TRUE
+"1553526_at",0.482805047227557,0.0275582886935045,2.3588541957497,-3.54147493446764,1.35807584021323,"NLRP8","NLR family pyrin domain containing 8",TRUE
+"1553527_at",0.870297378390937,0.50853700310624,0.671990299693388,-5.72210131500033,0.253425406495665,"NLRP9","NLR family pyrin domain containing 9",TRUE
+"219680_at",0.820536502908875,0.379990774700118,0.895796729706454,-5.55621880320135,0.723175198744805,"NLRX1","NLR family member X1",TRUE
+"1553695_a_at",0.968451827985008,0.851866192239291,0.188931777283274,-5.9223125967241,0.134094077280494,"NLRX1","NLR family member X1",TRUE
+"205204_at",0.255831879596455,0.00372596303420582,3.24116299599179,-1.81358527094106,2.48120307015692,"NMB","neuromedin B",TRUE
+"207333_at",0.9802233499944,0.907197155196694,0.117915368767533,-5.93291360659243,0.0758945234285022,"NMBR","neuromedin B receptor",TRUE
+"222497_x_at",0.901788521024914,0.599276118748509,0.533093093085262,-5.80220579683131,0.236304210542009,"NMD3","NMD3 ribosome export adaptor",TRUE
+"218036_x_at",0.937842878751575,0.72490442548388,0.356410900391782,-5.87800115395822,0.181054700159015,"NMD3","NMD3 ribosome export adaptor",TRUE
+"231870_s_at",0.968262726161738,0.850686217788318,0.190455798306747,-5.92203146707724,0.0865304378003113,"NMD3","NMD3 ribosome export adaptor",TRUE
+"201577_at",0.632216562924782,0.103365958474229,-1.69875388810094,-4.62411419447337,-0.590476451582413,"NME1","NME/NM23 nucleoside diphosphate kinase 1",TRUE
+"201268_at",0.990810941805126,0.956611035197697,0.0550258545123041,-5.9382088368501,0.0190198030567199,"NME1-NME2///NME2","NME1-NME2 readthrough///NME/NM23 nucleoside diphosphate kinase 2",TRUE
+"204862_s_at",0.793654340638017,0.325459972042889,-1.00560974988412,-5.45878934638135,-1.05194111471904,"NME3","NME/NM23 nucleoside diphosphate kinase 3",TRUE
+"212739_s_at",0.933815609540291,0.706754776983855,-0.381105561111703,-5.86918825883316,-0.402458383831229,"NME4","NME/NM23 nucleoside diphosphate kinase 4",TRUE
+"206197_at",0.919354071504066,0.656780395254493,0.450425263206805,-5.84134690360804,0.309118400617884,"NME5","NME/NM23 family member 5",TRUE
+"205851_at",0.896115372949367,0.577680608975724,-0.56510415505304,-5.7853290340585,-0.177476990226872,"NME6","NME/NM23 nucleoside diphosphate kinase 6",TRUE
+"227556_at",0.416665904944489,0.0169714672210586,-2.5815269709047,-3.12921488082139,-1.91336314903537,"NME7","NME/NM23 family member 7",TRUE
+"219553_at",0.965365698026603,0.838433571769388,-0.206308988304454,-5.91897365632226,-0.0901585754157548,"NME7","NME/NM23 family member 7",TRUE
+"220384_at",0.61760967235709,0.0882216586730033,1.78343156980688,-4.4989529475361,0.637696253980947,"NME8","NME/NM23 family member 8",TRUE
+"1562619_at",0.737123149977386,0.222830002773453,1.25422862208133,-5.20122542530063,0.455823502371062,"NME9","NME/NM23 family member 9",TRUE
+"203964_at",0.474859593446097,0.0261016224479069,2.38419006282345,-3.49558567168731,2.57396739435935,"NMI","N-myc and STAT interactor",TRUE
+"229852_at",0.677509122383198,0.145041305072654,-1.51052176347501,-4.88555926927998,-0.538682508183721,"NMNAT1","nicotinamide nucleotide adenylyltransferase 1",TRUE
+"223692_at",0.724970327905974,0.202674557418914,-1.31283498158163,-5.13336516538196,-0.464531782902318,"NMNAT1","nicotinamide nucleotide adenylyltransferase 1",TRUE
+"1569631_at",0.977930820766623,0.89348067155774,-0.135448028311368,-5.93075168715947,-0.0495475279861459,"NMNAT1","nicotinamide nucleotide adenylyltransferase 1",TRUE
+"1552712_a_at",0.330153165990401,0.00792850675711745,2.91817002814699,-2.4725817125596,2.43937901275504,"NMNAT2","nicotinamide nucleotide adenylyltransferase 2",TRUE
+"1556029_s_at",0.335883201003624,0.00830569890730498,2.89797725261523,-2.51293591476278,2.10401279731482,"NMNAT2","nicotinamide nucleotide adenylyltransferase 2",TRUE
+"209755_at",0.466300647363886,0.0243137738219463,2.41713478383659,-3.43550798577041,3.05790302565564,"NMNAT2","nicotinamide nucleotide adenylyltransferase 2",TRUE
+"1562818_at",0.712975827977365,0.187535263786271,1.35991416389239,-5.07695921726824,0.560626143903232,"NMNAT2","nicotinamide nucleotide adenylyltransferase 2",TRUE
+"228090_at",0.765787435787707,0.265991206091346,-1.14115135935804,-5.32457193438548,-0.901399674137035,"NMNAT3","nicotinamide nucleotide adenylyltransferase 3",TRUE
+"243738_at",0.954387719376857,0.790100519485872,0.269418847152564,-5.90439097534732,0.087616912708401,"NMNAT3","nicotinamide nucleotide adenylyltransferase 3",TRUE
+"223206_s_at",0.565795244949651,0.0567192270245823,-2.01037123984877,-4.14228858358955,-0.791460817225008,"NMRAL1","NmrA like redox sensor 1",TRUE
+"231271_x_at",0.713330901550199,0.187950986180729,-1.35858219661884,-5.0785779351563,-0.404824705219026,"NMRAL1","NmrA like redox sensor 1",TRUE
+"241418_at",0.517237066850276,0.0364691155502115,2.2263480092849,-3.77683558049457,1.42713787755128,"NMRAL1P1","NmrA like redox sensor 1 pseudogene 1",TRUE
+"1562761_at",0.640067422642767,0.110767582687507,1.66115999765494,-4.67821627506206,0.729862958101194,"NMRK1","nicotinamide riboside kinase 1",TRUE
+"219147_s_at",0.993225426079816,0.968212070187461,0.0403035798045409,-5.93889233682014,0.0239321569771374,"NMRK1","nicotinamide riboside kinase 1",TRUE
+"221051_s_at",0.898609426925686,0.587994478789809,0.549743468461503,-5.79354670027699,0.306078677219843,"NMRK2","nicotinamide riboside kinase 2",TRUE
+"201157_s_at",0.623503825356688,0.0946209587700197,1.74624068363312,-4.55447938062807,0.520623517394226,"NMT1","N-myristoyltransferase 1",TRUE
+"201158_at",0.851650449893991,0.455667490176822,0.759314540062375,-5.6626983224732,0.230896036519287,"NMT1","N-myristoyltransferase 1",TRUE
+"201159_s_at",0.971941282090292,0.865539574322345,0.171304003523328,-5.92540068219663,0.0550759074577147,"NMT1","N-myristoyltransferase 1",TRUE
+"205006_s_at",0.643852971767472,0.114741202111403,1.64184520118095,-4.70565402488021,0.980099820865915,"NMT2","N-myristoyltransferase 2",TRUE
+"205005_s_at",0.6729254853814,0.138597419129034,1.53640519240907,-4.85103517783112,0.936915950184192,"NMT2","N-myristoyltransferase 2",TRUE
+"215743_at",0.773107052530371,0.283708117732223,1.09866901451261,-5.36826562514992,0.61831480649738,"NMT2","N-myristoyltransferase 2",TRUE
+"215069_at",0.782190417000878,0.303963416369779,1.05238948175801,-5.41418301137717,0.749688462699563,"NMT2","N-myristoyltransferase 2",TRUE
+"206023_at",0.710383535193614,0.183300989915439,1.3736152955205,-5.06023173584126,1.38914456534357,"NMU","neuromedin U",TRUE
+"221383_at",0.892000472179706,0.562163423459323,0.58847741629311,-5.77240390790194,0.262960792308318,"NMUR1","neuromedin U receptor 1",TRUE
+"224088_at",0.863230457544525,0.487260538130402,0.706467932548995,-5.69947230839971,0.264642653657743,"NMUR2","neuromedin U receptor 2",TRUE
+"204239_s_at",0.968396410536907,0.851439624606938,0.189482666718132,-5.92221123625846,0.113943960138767,"NNAT","neuronatin",TRUE
+"231559_at",0.841813886364358,0.433955211742403,0.796918849811259,-5.63500489738143,0.400050604803702,"NNMT","nicotinamide N-methyltransferase",TRUE
+"238530_at",0.696129677967645,0.1661755437931,1.43173637315365,-4.98773276539846,0.792391900098746,"NNT","nicotinamide nucleotide transhydrogenase",TRUE
+"202784_s_at",0.757361197594703,0.253355268701665,1.17273851702704,-5.29113851785089,1.72518787718977,"NNT","nicotinamide nucleotide transhydrogenase",TRUE
+"202783_at",0.796867290731448,0.329692553720409,0.996655458154675,-5.46711831205128,1.19342570609609,"NNT","nicotinamide nucleotide transhydrogenase",TRUE
+"244531_at",0.945272089973488,0.752952989854749,-0.318681140661008,-5.89033917945069,-0.261300436839725,"NNT","nicotinamide nucleotide transhydrogenase",TRUE
+"1558801_at",0.581852599439475,0.0640554424460905,1.94909711852464,-4.24149990254287,1.95014491496319,"NNT-AS1","NNT antisense RNA 1",TRUE
+"223157_at",0.97112136867183,0.86159635024828,-0.176381672981354,-5.92454205598758,-0.0544470941765898,"NOA1","nitric oxide associated 1",TRUE
+"223018_at",0.977874971442423,0.893214271130273,0.135788958772575,-5.93070668688916,0.0564649557510482,"NOB1","NIN1/PSMD8 binding protein 1 homolog",TRUE
+"234519_at",0.934867348047609,0.710653509947841,0.375781032724597,-5.8711376912777,0.175843264598176,"NOBOX","NOBOX oogenesis homeobox",TRUE
+"1559139_at",0.732833336538006,0.217055382750735,1.27058713633287,-5.18254979335187,0.53535178375459,"NOC2L","NOC2 like nucleolar associated transcriptional repressor",TRUE
+"202115_s_at",0.821137675198948,0.382011092900071,0.891937361672533,-5.55945441376724,0.249800555582921,"NOC2L","NOC2 like nucleolar associated transcriptional repressor",TRUE
+"218889_at",0.757361197594703,0.253305269422554,1.1728658013389,-5.29100217562074,0.476913528577651,"NOC3L","NOC3 like DNA replication regulator",TRUE
+"218860_at",0.91876780831279,0.654868791134512,-0.45311967637343,-5.84017269501637,-0.182744020263263,"NOC4L","nucleolar complex associated 4 homolog",TRUE
+"1554283_at",0.755049574909504,0.248822669117761,1.18435414288514,-5.27864305601529,0.439634516195285,"NOCT","nocturnin",TRUE
+"220671_at",0.941158863404109,0.736281446079267,0.341046524690483,-5.88319008086148,0.0803775434256071,"NOCT","nocturnin",TRUE
+"224190_x_at",0.750942397683331,0.243968720805652,1.19696999425091,-5.26494998617617,0.469796026453978,"NOD1","nucleotide binding oligomerization domain containing 1",TRUE
+"221073_s_at",0.931121627074226,0.695011723658745,0.397211892859664,-5.86312679742092,0.125754480187856,"NOD1","nucleotide binding oligomerization domain containing 1",TRUE
+"220066_at",0.868397087637799,0.503724187577163,-0.67971655153186,-5.71712433102974,-1.04347745720383,"NOD2","nucleotide binding oligomerization domain containing 2",TRUE
+"230916_at",0.422574093216884,0.0176815115321178,2.56298450684114,-3.16428122184936,1.75549935506769,"NODAL","nodal growth differentiation factor",TRUE
+"237896_at",0.67606695078322,0.142616184695266,1.5201499545942,-4.87277147941699,0.685240735662981,"NODAL","nodal growth differentiation factor",TRUE
+"220689_at",0.815977292327875,0.36692123576739,-0.921096136973998,-5.53468890163967,-0.446948954674435,"NODAL","nodal growth differentiation factor",TRUE
+"231798_at",0.85334340854827,0.461290259775293,0.749753973169984,-5.66953746459119,1.18364885773594,"NOG","noggin",TRUE
+"218591_s_at",0.463552233135475,0.0236091824738402,-2.43073767918378,-3.41056999031347,-1.38180596972784,"NOL10","nucleolar protein 10",TRUE
+"222684_s_at",0.993432824584085,0.968993421020816,-0.0393123730925009,-5.93893077089326,-0.0130588348061558,"NOL10","nucleolar protein 10",TRUE
+"221970_s_at",0.94895689004559,0.768040223895782,-0.298583446080866,-5.89635383655869,-0.116507592107613,"NOL11","nucleolar protein 11",TRUE
+"219324_at",0.907546644378305,0.616716744860202,0.507647614948021,-5.81493787200134,0.177498017124348,"NOL12","nucleolar protein 12",TRUE
+"222057_at",0.977930820766623,0.893430211261793,0.135512604466794,-5.93074317225906,0.117762894029915,"NOL12","nucleolar protein 12",TRUE
+"210276_s_at",0.713005775571409,0.187629277411298,1.35961274224401,-5.07732564595083,0.476400491193928,"NOL12///TRIOBP","nucleolar protein 12///TRIO and F-actin binding protein",TRUE
+"59625_at",0.716280952967285,0.192057245951934,-1.34554894663278,-5.094347033592,-0.762165143449261,"NOL3","nucleolar protein 3",TRUE
+"221566_s_at",0.899998627338565,0.594517223954541,-0.540097806885909,-5.79859451250452,-0.411815776453683,"NOL3","nucleolar protein 3",TRUE
+"1558738_at",0.900692252557887,0.595882712936345,0.538085133010261,-5.7996368416429,0.421427798025757,"NOL3","nucleolar protein 3",TRUE
+"221567_at",0.918873031296782,0.65528629836841,-0.452530908231636,-5.84042986279237,-0.396890368334184,"NOL3","nucleolar protein 3",TRUE
+"238605_at",0.771011793494937,0.279693619509679,-1.10812201791041,-5.35867015241097,-0.91697320347219,"NOL4","nucleolar protein 4",TRUE
+"206045_s_at",0.854040699678541,0.463124827327527,0.746649695618804,-5.67174045839796,0.394518414477029,"NOL4","nucleolar protein 4",TRUE
+"230954_at",0.819780516863333,0.377450008820461,0.900669486331156,-5.55211513288257,0.837748033581422,"NOL4L","nucleolar protein 4 like",TRUE
+"230955_s_at",0.865187396415238,0.4944583552956,0.694709858791928,-5.7073110301397,0.52477411242416,"NOL4L","nucleolar protein 4 like",TRUE
+"241830_at",0.952155285118184,0.78105875689556,0.281342110027589,-5.90120415251684,0.194915371214549,"NOL4L","nucleolar protein 4 like",TRUE
+"225224_at",0.988173753615796,0.943641093062453,-0.0715002644733958,-5.93719378057033,-0.0501049962566693,"NOL4L","nucleolar protein 4 like",TRUE
+"234031_at",0.989627445997672,0.949716544883363,-0.0637809906129971,-5.9377022949685,-0.0337732602232714,"NOL4L","nucleolar protein 4 like",TRUE
+"1558679_at",0.990918916504081,0.95711491406971,0.0543861729721199,-5.9382429209238,0.0258447371506261,"NOL4L","nucleolar protein 4 like",TRUE
+"218199_s_at",0.821424121108148,0.383146867899671,-0.8897735910616,-5.56126281369441,-0.273285701080253,"NOL6","nucleolar protein 6",TRUE
+"232566_at",0.859502367311367,0.477412577174595,0.72271897081294,-5.68843205346847,0.344990865039296,"NOL6","nucleolar protein 6",TRUE
+"222554_s_at",0.925511384407886,0.67755628495156,-0.421353808715793,-5.85357877421336,-0.148995406682504,"NOL6","nucleolar protein 6",TRUE
+"228076_s_at",0.991254515545788,0.959117984036039,0.051843473855095,-5.93837446366282,0.0194634124978137,"NOL6","nucleolar protein 6",TRUE
+"210097_s_at",0.783844746433788,0.306690310451171,1.04632882569297,-5.42006508555237,0.339772380860518,"NOL7","nucleolar protein 7",TRUE
+"202882_x_at",0.858994261239434,0.475347402512608,0.726151627434335,-5.68606950850936,0.24513240221718,"NOL7","nucleolar protein 7",TRUE
+"213838_at",0.888232641270866,0.553929215084082,0.60101531509471,-5.76526187776242,0.228891971187695,"NOL7","nucleolar protein 7",TRUE
+"202881_x_at",0.96479405380661,0.837064254524849,-0.208083979363506,-5.91861613993046,-0.130287957641176,"NOL7","nucleolar protein 7",TRUE
+"218244_at",0.943631120237335,0.747811780232672,0.325560026681964,-5.88819142630664,0.145156836904116,"NOL8","nucleolar protein 8",TRUE
+"1554082_a_at",0.871744769522775,0.513760104941267,0.663651612265322,-5.72741167829882,0.209041786989097,"NOL9","nucleolar protein 9",TRUE
+"218754_at",0.918993592109901,0.655393541708956,0.452379700043884,-5.84049585604214,0.138034238796019,"NOL9","nucleolar protein 9",TRUE
+"1554084_a_at",0.919156359329732,0.655748793549539,0.451878887729152,-5.84071427598424,0.149348570321383,"NOL9","nucleolar protein 9",TRUE
+"211951_at",0.904832003218088,0.609505003195892,0.518127292251948,-5.80976765481801,0.167517811099362,"NOLC1","nucleolar and coiled-body phosphoprotein 1",TRUE
+"205895_s_at",0.920734496427305,0.662782866317,0.441986611890593,-5.84497996808619,0.165598158228496,"NOLC1","nucleolar and coiled-body phosphoprotein 1",TRUE
+"211949_s_at",0.929972194057784,0.691040640536066,0.402682551151913,-5.86101174882001,0.130276034435012,"NOLC1","nucleolar and coiled-body phosphoprotein 1",TRUE
+"227161_at",0.820288124919738,0.378567912062702,0.898522887778075,-5.55392546232826,0.413314437802049,"NOM1","nucleolar protein with MIF4G domain 1",TRUE
+"229220_x_at",0.854400503339099,0.465726326037006,-0.74226022269696,-5.67484072533045,-0.342864380600375,"NOM1","nucleolar protein with MIF4G domain 1",TRUE
+"242922_at",0.800179799309599,0.335809894540172,-0.983853312740921,-5.47890882078738,-0.585512919516053,"NOMO3","NODAL modulator 3",TRUE
+"210470_x_at",0.919375181609246,0.657159864372692,0.449890803318588,-5.84157900175643,0.1724165972265,"NONO","non-POU domain containing, octamer-binding",TRUE
+"208698_s_at",0.966593471043185,0.844654048597869,0.198254072673294,-5.92055773360672,0.0842219283616519,"NONO","non-POU domain containing, octamer-binding",TRUE
+"200057_s_at",0.986455005400648,0.936957845277818,-0.0799969482114614,-5.93656699515755,-0.0197256989849972,"NONO","non-POU domain containing, octamer-binding",TRUE
+"217962_at",0.989475734766121,0.947968256816328,-0.0660018811804104,-5.93756193552675,-0.0191835925974004,"NOP10","NOP10 ribonucleoprotein",TRUE
+"214661_s_at",0.753862100951903,0.247124609357554,-1.18874642588024,-5.27389007691069,-0.471802144422734,"NOP14","NOP14 nucleolar protein",TRUE
+"215141_at",0.329541287798136,0.00786596214758685,-2.9216068159627,-2.46570244491924,-1.8653665807909,"NOP14-AS1","NOP14 antisense RNA 1",TRUE
+"214123_s_at",0.643688366500038,0.114584176908724,-1.6425976954133,-4.7045896620517,-1.12082035225812,"NOP14-AS1","NOP14 antisense RNA 1",TRUE
+"214685_at",0.695744345349551,0.165429776361197,1.43437441313552,-4.98438359227612,0.841711522545693,"NOP14-AS1","NOP14 antisense RNA 1",TRUE
+"213833_x_at",0.822010986888098,0.38562335731072,0.885070131138219,-5.56517975591962,0.611040699067279,"NOP16","NOP16 nucleolar protein",TRUE
+"203023_at",0.846785928264532,0.445300210506846,-0.777130508533279,-5.64973523264104,-0.330192412056949,"NOP16","NOP16 nucleolar protein",TRUE
+"214011_s_at",0.851975164401837,0.457098115639021,-0.756875323854097,-5.66445100501736,-0.288881130473696,"NOP16","NOP16 nucleolar protein",TRUE
+"209327_s_at",0.964685626382167,0.836651791765661,0.208618772083701,-5.91850782476824,0.157344650976768,"NOP16","NOP16 nucleolar protein",TRUE
+"214427_at",0.947778780715578,0.761737326462441,-0.306963787927172,-5.89389301885209,-0.107074330896699,"NOP2","NOP2 nucleolar protein",TRUE
+"223096_at",0.948877410850222,0.767293426401646,0.29957523815598,-5.89606612755541,0.0776631789552038,"NOP58","NOP58 ribonucleoprotein",TRUE
+"1555390_at",0.77340139236553,0.284768575697757,1.09618812978443,-5.37077179250675,0.356137177111443,"NOP9","NOP9 nucleolar protein",TRUE
+"225514_at",0.938429637812955,0.726319652187121,-0.35449498091303,-5.87866053566552,-0.145758780590013,"NOP9","NOP9 nucleolar protein",TRUE
+"1558028_x_at",0.854184492233394,0.464780732657072,0.743854018449651,-5.67371703727993,0.380308211864186,"NORAD","non-coding RNA activated by DNA damage",TRUE
+"224597_at",0.959203345279235,0.815355364525555,-0.236319975736921,-5.91251895035953,-0.0615171539554673,"NORAD","non-coding RNA activated by DNA damage",TRUE
+"231916_at",0.695812999227098,0.165853364035634,1.43287486543627,-4.98628798966067,0.681750231279514,"NOS1","nitric oxide synthase 1",TRUE
+"207309_at",0.768243637564985,0.271372392239176,-1.12803498954628,-5.33821873496419,-0.334766581415627,"NOS1","nitric oxide synthase 1",TRUE
+"207310_s_at",0.774230543658252,0.289101452911739,-1.08612038018495,-5.38089035714155,-0.461588139266943,"NOS1","nitric oxide synthase 1",TRUE
+"239132_at",0.860714927752408,0.480455471752099,0.71767696532246,-5.6918829395097,0.301104427013422,"NOS1","nitric oxide synthase 1",TRUE
+"240911_at",0.872238421308015,0.515116199029157,0.66149434018877,-5.72877515875696,0.252564498366608,"NOS1","nitric oxide synthase 1",TRUE
+"1560974_s_at",0.888972420461865,0.556351185770823,0.597317468872041,-5.767383427994,0.306625570145674,"NOS1","nitric oxide synthase 1",TRUE
+"215153_at",0.821745015752602,0.384549347815689,-0.887107505777464,-5.5634854347932,-0.670406230861584,"NOS1AP","nitric oxide synthase 1 adaptor protein",TRUE
+"1563512_at",0.91671872326659,0.647634446840257,0.463347631997305,-5.83565294294969,0.19391410859906,"NOS1AP","nitric oxide synthase 1 adaptor protein",TRUE
+"210037_s_at",0.96200396340887,0.827411172562993,0.220616657038158,-5.91600505137168,0.100058033504011,"NOS2","nitric oxide synthase 2",TRUE
+"229093_at",0.803526988019261,0.341706556898689,-0.971664004029558,-5.49000589067662,-0.705707153914806,"NOS3","nitric oxide synthase 3",TRUE
+"205581_s_at",0.956084625435459,0.80138992007423,0.254587244010173,-5.90816386151368,0.266940006482725,"NOS3","nitric oxide synthase 3",TRUE
+"217950_at",0.855395723404557,0.467927986057703,-0.738556755754126,-5.67744298766945,-0.255453535932116,"NOSIP","nitric oxide synthase interacting protein",TRUE
+"226992_at",0.984244246588495,0.923408626796359,-0.0972418340223667,-5.93507887357115,-0.0942523326573088,"NOSTRIN","nitric oxide synthase trafficking",TRUE
+"218902_at",0.940227139261806,0.732931118478432,0.345562201041053,-5.88168847362374,0.134177171453835,"NOTCH1","notch 1",TRUE
+"223508_at",0.979588787486838,0.902105708197577,-0.124418632098656,-5.93214655689681,-0.0674390071346895,"NOTCH1","notch 1",TRUE
+"210756_s_at",0.78969417320323,0.31752241036548,-1.02262312844541,-5.44277827128465,-0.365632339784906,"NOTCH2","notch 2",TRUE
+"202443_x_at",0.821903997044289,0.385028444488438,-0.886198210208839,-5.56424206909641,-0.26833601553542,"NOTCH2","notch 2",TRUE
+"212377_s_at",0.830592576740524,0.402973868056008,-0.852654995707752,-5.59164977465704,-0.282161137626046,"NOTCH2","notch 2",TRUE
+"202445_s_at",0.995432017261604,0.978682266788682,0.0270243201737364,-5.93932777804441,0.00762884046242363,"NOTCH2","notch 2",TRUE
+"214722_at",0.769774279128662,0.277259531392423,1.11390167521922,-5.35276745176716,0.534438868159583,"NOTCH2NL","notch 2 N-terminal like",TRUE
+"203237_s_at",0.231131606308726,0.0029381560545159,3.34112563610156,-1.60526318496283,1.7477868720581,"NOTCH3","notch 3",TRUE
+"203238_s_at",0.867267132647906,0.499531428567215,0.686481405155131,-5.71272197846688,0.898697426471495,"NOTCH3","notch 3",TRUE
+"240786_at",0.683019114815084,0.152061342749356,1.48337404392615,-4.92126495131777,0.508655943724445,"NOTCH4","notch 4",TRUE
+"205247_at",0.720010760158751,0.195808687568367,1.33383194155057,-5.1084148047525,0.668743349006232,"NOTCH4","notch 4",TRUE
+"228649_at",0.606138724709726,0.079695445067253,1.83677753094942,-4.41782454513004,0.815705643125385,"NOTUM","NOTUM, palmitoleoyl-protein carboxylesterase",TRUE
+"214321_at",0.62986301194198,0.101149903663554,1.71045358780867,-4.60709089579601,1.73881025246182,"NOV","nephroblastoma overexpressed",TRUE
+"204501_at",0.708894565317004,0.181154301061467,1.38065738913786,-5.05157990799676,0.924388855097389,"NOV","nephroblastoma overexpressed",TRUE
+"207437_at",0.45647012846614,0.022302489471845,-2.45699233799594,-3.36222362121945,-3.47549757556165,"NOVA1","NOVA alternative splicing regulator 1",TRUE
+"205794_s_at",0.624374299616567,0.0959002128036598,-1.73906601546157,-4.56509190362685,-1.4024754518204,"NOVA1","NOVA alternative splicing regulator 1",TRUE
+"231614_at",0.966064677476069,0.84187060588147,-0.20185667043049,-5.91985701424531,-0.192468472588064,"NOVA1","NOVA alternative splicing regulator 1",TRUE
+"238904_at",0.837368340567858,0.420388086575427,0.821007791862852,-5.61660366684873,0.48228680125882,"NOVA2","NOVA alternative splicing regulator 2",TRUE
+"206477_s_at",0.862988128730612,0.486966799224451,-0.70694988876402,-5.69914832849066,-0.396515126171928,"NOVA2","NOVA alternative splicing regulator 2",TRUE
+"235560_at",0.899331416659389,0.589906995548242,-0.546909861417393,-5.79503860251767,-0.402805122265394,"NOVA2","NOVA alternative splicing regulator 2",TRUE
+"206476_s_at",0.909934011695618,0.625021358058126,0.495650694749386,-5.82073008562345,0.268071710916749,"NOVA2","NOVA alternative splicing regulator 2",TRUE
+"207380_x_at",0.797752695752955,0.331329109856084,0.993214573059654,-5.47030091094308,0.636185818609076,"NOX1","NADPH oxidase 1",TRUE
+"210808_s_at",0.818587566823571,0.37185355447198,0.911479352626759,-5.54293801854512,0.387756154928717,"NOX1","NADPH oxidase 1",TRUE
+"207217_s_at",0.832605695407954,0.408993709813177,0.84161855553705,-5.60045213526892,0.444439833576896,"NOX1","NADPH oxidase 1",TRUE
+"206418_at",0.979588787486838,0.90259376259868,0.123795010570019,-5.93222189413445,0.116292862566632,"NOX1","NADPH oxidase 1",TRUE
+"221089_at",0.956398858120188,0.80219815595991,0.253527688416387,-5.9084252712172,0.112428724212377,"NOX3","NADPH oxidase 3",TRUE
+"236843_at",0.896428361916712,0.580892475543357,0.560306072597405,-5.78791951138415,0.569289296169636,"NOX4","NADPH oxidase 4",TRUE
+"219773_at",0.947172271524565,0.760059190505144,-0.309198802017539,-5.89322532402165,-0.227904151785226,"NOX4","NADPH oxidase 4",TRUE
+"1553023_a_at",0.728385463227073,0.20983590118996,1.29151639056266,-5.1583549756437,1.04884070949615,"NOX5","NADPH oxidase, EF-hand calcium binding domain 5",TRUE
+"220641_at",0.838999550222784,0.424621607273186,0.813439652136815,-5.62244026044258,0.695153858781183,"NOX5","NADPH oxidase, EF-hand calcium binding domain 5",TRUE
+"232373_at",0.77673212102109,0.294183167468292,-1.0744501219115,-5.39251526881741,-0.380885406088141,"NOXA1","NADPH oxidase activator 1",TRUE
+"235329_at",0.407748633394319,0.0156570308556471,2.61785906878353,-3.06014369375692,2.24752960762047,"NOXO1","NADPH oxidase organizer 1",TRUE
+"231566_at",0.571677937624457,0.0595501460220952,1.9859378808202,-4.18209799697245,0.712078797436954,"NOXRED1","NADP dependent oxidoreductase domain containing 1",TRUE
+"221300_at",0.949780026731506,0.772644097466189,0.292475929118871,-5.89810471512639,0.115209353143539,"NPAP1","nuclear pore associated protein 1",TRUE
+"206699_x_at",0.729083413548563,0.210667581973692,1.28907728543412,-5.16119197270284,1.11314420622287,"NPAS1","neuronal PAS domain protein 1",TRUE
+"216975_x_at",0.929086764207678,0.687260815575955,-0.407901366089308,-5.85896752473125,-0.348145825853261,"NPAS1","neuronal PAS domain protein 1",TRUE
+"39548_at",0.61591966964196,0.0869559948953424,1.79106083376202,-4.48745659203749,1.28215554472175,"NPAS2","neuronal PAS domain protein 2",TRUE
+"205460_at",0.65284137151906,0.122022471506825,1.60786576562404,-4.75332439517732,2.03645695694407,"NPAS2","neuronal PAS domain protein 2",TRUE
+"213462_at",0.693742297578797,0.162802908325934,1.44374344283688,-4.97244827190462,1.39429395052118,"NPAS2","neuronal PAS domain protein 2",TRUE
+"39549_at",0.69385705848116,0.163249868103775,1.44214075586719,-4.97449445026801,1.90586640302757,"NPAS2","neuronal PAS domain protein 2",TRUE
+"205459_s_at",0.789927874973432,0.319090552246806,1.01923861592323,-5.4459827529097,0.809645073606695,"NPAS2","neuronal PAS domain protein 2",TRUE
+"229281_at",0.468735421183467,0.0250424982752148,-2.40344459010227,-3.46052856666197,-3.39277820147849,"NPAS3","neuronal PAS domain protein 3",TRUE
+"220316_at",0.718812966125406,0.194864040857793,-1.33676569037687,-5.10490215544994,-1.18323115813114,"NPAS3","neuronal PAS domain protein 3",TRUE
+"230412_at",0.856874648266698,0.471420472316103,-0.732703052058091,-5.68153093730196,-0.693900387022056,"NPAS3","neuronal PAS domain protein 3",TRUE
+"1569661_at",0.88698237223329,0.551088215693196,0.605363733661134,-5.76275090266669,0.61622000960088,"NPAS3","neuronal PAS domain protein 3",TRUE
+"1554635_a_at",0.889452275006221,0.557513938,-0.595545171154413,-5.76839575687683,-0.459565709052198,"NPAS3","neuronal PAS domain protein 3",TRUE
+"233865_at",0.914777193128009,0.641038379103914,-0.47271709248464,-5.83142585704292,-0.341481022417641,"NPAS3","neuronal PAS domain protein 3",TRUE
+"233293_at",0.939618331738051,0.729267561176117,-0.350508460379888,-5.88002127900607,-0.222606595982215,"NPAS3","neuronal PAS domain protein 3",TRUE
+"234014_at",0.959931948475729,0.818725460677391,0.231924301424807,-5.91351880551438,0.137705725343717,"NPAS3","neuronal PAS domain protein 3",TRUE
+"222172_at",0.98539961718117,0.928179417461023,-0.0911665974914725,-5.93563613997083,-0.0938819568722753,"NPAS3","neuronal PAS domain protein 3",TRUE
+"1554299_at",0.861659105448003,0.483136994715467,0.713249142660775,-5.69489450369035,0.533421550837332,"NPAS4","neuronal PAS domain protein 4",TRUE
+"240794_at",0.957228789717225,0.806453218852209,-0.247954377434055,-5.90978245754064,-0.0696915986731006,"NPAS4","neuronal PAS domain protein 4",TRUE
+"211584_s_at",0.659870891937597,0.127622889468932,1.58286512757032,-4.78790422724789,0.525051908802798,"NPAT","nuclear protein, coactivator of histone transcription",TRUE
+"211585_at",0.768852835478002,0.273286325946131,1.12341583417533,-5.34299150833991,0.925761839069233,"NPAT","nuclear protein, coactivator of histone transcription",TRUE
+"209798_at",0.879161148925378,0.532941325112664,0.633424020136316,-5.74612810238357,0.213913648608688,"NPAT","nuclear protein, coactivator of histone transcription",TRUE
+"1553663_a_at",0.934612165247339,0.709811270349279,0.376930343726742,-5.87071919153105,0.263315481679396,"NPB","neuropeptide B",TRUE
+"231752_at",0.997171203405,0.985653856296655,0.0181852260548347,-5.93952240906384,0.00548570924269942,"NPBWR1","neuropeptides B/W receptor 1",TRUE
+"221358_at",0.953593633849874,0.786353517845883,0.274355032221942,-5.90308825877871,0.192485558109964,"NPBWR2","neuropeptides B/W receptor 2",TRUE
+"238568_s_at",0.799150634740328,0.333791394824661,-0.988059636596468,-5.47505017520894,-0.570822080453219,"NPC1","NPC intracellular cholesterol transporter 1",TRUE
+"238873_at",0.94895689004559,0.76888118097824,-0.29746697020437,-5.89667658330324,-0.24109488922417,"NPC1","NPC intracellular cholesterol transporter 1",TRUE
+"217584_at",0.957868442073393,0.810451115366206,0.242725212181577,-5.91102856963938,0.246238764060625,"NPC1","NPC intracellular cholesterol transporter 1",TRUE
+"202679_at",0.958813918694598,0.81371604282301,-0.238459887910067,-5.91202544116858,-0.115170258365378,"NPC1","NPC intracellular cholesterol transporter 1",TRUE
+"220106_at",0.634202341398092,0.105301768502391,-1.68870683016842,-4.63866270205888,-1.1625775141002,"NPC1L1","NPC1 like intracellular cholesterol transporter 1",TRUE
+"224305_s_at",0.673366993714442,0.139329390325413,1.53341588601843,-4.85504622393472,0.893206285495358,"NPC1L1","NPC1 like intracellular cholesterol transporter 1",TRUE
+"224306_at",0.881466832418197,0.538302834726682,-0.625081163931673,-5.75114615339653,-0.359982117465673,"NPC1L1","NPC1 like intracellular cholesterol transporter 1",TRUE
+"200701_at",0.957017346544368,0.805359654034255,0.249385962836378,-5.9094367065107,0.105446674879371,"NPC2","NPC intracellular cholesterol transporter 2",TRUE
+"224140_at",0.713460685500024,0.188251403503177,1.35762111020381,-5.07974510502556,0.480028299332642,"NPCDR1","nasopharyngeal carcinoma, down-regulated 1",TRUE
+"218086_at",0.224460431387891,0.00276290572151899,-3.36690175132983,-1.55126885140413,-2.83276312260606,"NPDC1","neural proliferation, differentiation and control 1",TRUE
+"235033_at",0.402463840838386,0.0146564938077111,-2.64748932587431,-3.00346642901705,-1.31941870323187,"NPEPL1","aminopeptidase-like 1",TRUE
+"89476_r_at",0.772420279152863,0.282775000506525,-1.10085754901906,-5.36605060500847,-0.51454449277861,"NPEPL1","aminopeptidase-like 1",TRUE
+"201454_s_at",0.798428326317339,0.332936728053371,0.989845948090025,-5.47340698322818,0.386616590880678,"NPEPPS","aminopeptidase puromycin sensitive",TRUE
+"214101_s_at",0.944138668824804,0.750175232350602,0.322395782042137,-5.88918501902968,0.142661081893756,"NPEPPS","aminopeptidase puromycin sensitive",TRUE
+"201455_s_at",0.948429371744093,0.764995442246143,0.302629029511557,-5.89517431365522,0.133401557826993,"NPEPPS","aminopeptidase puromycin sensitive",TRUE
+"214184_at",0.730768621354511,0.213348383903424,1.28126549377582,-5.17024738865357,1.08769193565633,"NPFF","neuropeptide FF-amide peptide precursor",TRUE
+"206402_s_at",0.88767000285873,0.552490355688753,0.603216159877667,-5.76399319389274,0.295767639204398,"NPFF","neuropeptide FF-amide peptide precursor",TRUE
+"221387_at",0.89316156038085,0.567224542795109,0.580818150064006,-5.77669524645859,0.385862912448641,"NPFFR1","neuropeptide FF receptor 1",TRUE
+"224169_at",0.833947935066508,0.41174172785101,0.836614877535875,-5.60440765554823,0.654850274710983,"NPFFR2","neuropeptide FF receptor 2",TRUE
+"238843_at",0.896118635245982,0.578010175150467,0.564611213286683,-5.78559615987884,0.358697707048876,"NPHP1","nephrocystin 1",TRUE
+"206285_at",0.9116561917482,0.630603767996815,-0.487627646897947,-5.82452819051233,-0.352895404787617,"NPHP1","nephrocystin 1",TRUE
+"238844_s_at",0.932269331146744,0.701406906998812,0.388427514808179,-5.86646336259133,0.254622956114842,"NPHP1","nephrocystin 1",TRUE
+"235410_at",0.807944276806637,0.349592202259607,0.955585822895604,-5.50445011787309,0.405601322059097,"NPHP3","nephronophthisis 3 (adolescent)",TRUE
+"1553389_at",0.821468803512885,0.383787821068736,0.888554361531776,-5.56228000897339,0.457861863282916,"NPHP3","nephronophthisis 3 (adolescent)",TRUE
+"235432_at",0.895195476627048,0.572738857597549,0.572512760468851,-5.78128708392882,0.313067341269759,"NPHP3","nephronophthisis 3 (adolescent)",TRUE
+"225573_at",0.755598961025524,0.249564852979021,-1.18244140943727,-5.28070806686939,-0.464333006603738,"NPHP3-ACAD11///ACAD11///NPHP3","NPHP3-ACAD11 readthrough (NMD candidate)///acyl-CoA dehydrogenase family member 11///nephronophthisis 3 (adolescent)",TRUE
+"1569882_at",0.696737852624554,0.166516205217102,1.4305344996936,-4.98925695390874,0.945206838416468,"NPHP3-AS1","NPHP3 antisense RNA 1",TRUE
+"1556887_at",0.945764550538403,0.755146473667944,0.31575106901679,-5.89124022509966,0.100978279470547,"NPHP3-AS1","NPHP3 antisense RNA 1",TRUE
+"213471_at",0.761109548348834,0.26017976304432,-1.15553762968546,-5.30944417965807,-0.475144848842036,"NPHP4","nephronophthisis 4",TRUE
+"216344_at",0.913123070637484,0.635063019434889,-0.481242066268956,-5.82750782310384,-0.24934564212899,"NPHP4","nephronophthisis 4",TRUE
+"207673_at",0.657015752622694,0.125454137895245,1.59243604540878,-4.77471599172504,0.699966420022066,"NPHS1","NPHS1, nephrin",TRUE
+"220424_at",0.396220771188728,0.0136647858431674,-2.67880026918702,-2.94324458617193,-1.05888508630667,"NPHS2","NPHS2, podocin",TRUE
+"204538_x_at",0.647455721425462,0.118229500186773,-1.62534763272559,-4.72889475311479,-0.616486782554908,"NPIPA1","nuclear pore complex interacting protein family member A1",TRUE
+"215123_at",0.739189560382301,0.226237428457775,1.24472764867066,-5.21197686538888,0.478433135993534,"NPIPA5///NPIPB5///LOC613037///NPIPB4///NPIPB3","nuclear pore complex interacting protein family member A5///nuclear pore complex interacting protein family member B5///nuclear pore complex interacting protein member///nuclear pore complex interacting protein family member B4///nuclear pore complex interacting protein family member B3",TRUE
+"215002_at",0.97304633500821,0.869096494550631,-0.16672773064096,-5.9261530962993,-0.141769467973612,"NPIPA5///NPIPB5///NPIPB11///NPIPB8///LOC613037///NPIPB4///NPIPB3","nuclear pore complex interacting protein family member A5///nuclear pore complex interacting protein family member B5///nuclear pore complex interacting protein family member B11///nuclear pore complex interacting protein family member B8///nuclear pore complex interacting protein member///nuclear pore complex interacting protein family member B4///nuclear pore complex interacting protein family member B3",TRUE
+"215920_s_at",0.98539961718117,0.927760427094543,-0.0917000054480114,-5.93558864975159,-0.0628996402067328,"NPIPA5///NPIPB6///NPIPB15///PDXDC2P///NPIPB3///NPIPA1","nuclear pore complex interacting protein family member A5///nuclear pore complex interacting protein family member B6///nuclear pore complex interacting protein family member B15///pyridoxal dependent decarboxylase domain containing 2, pseudogene///nuclear pore complex interacting protein family member B3///nuclear pore complex interacting protein family member A1",TRUE
+"215921_at",0.673190784310977,0.138790682424975,-1.53561466207486,-4.85209651280775,-0.880009115749196,"NPIPA5///NPIPB6///NPIPB8///NPIPB3","nuclear pore complex interacting protein family member A5///nuclear pore complex interacting protein family member B6///nuclear pore complex interacting protein family member B8///nuclear pore complex interacting protein family member B3",TRUE
+"221992_at",0.91113043322449,0.62903411912071,-0.489880248008071,-5.8234679251295,-0.268320865464528,"NPIPB15","nuclear pore complex interacting protein family member B15",TRUE
+"243066_at",0.761748280722165,0.261054713096973,1.15335661674445,-5.31174831899926,0.845499878340314,"NPL","N-acetylneuraminate pyruvate lyase",TRUE
+"240440_at",0.812302873476553,0.358323337148026,0.938068185845711,-5.51993621787292,0.867880264060795,"NPL","N-acetylneuraminate pyruvate lyase",TRUE
+"221210_s_at",0.95803175442752,0.810809389531315,-0.242256936837947,-5.91113887152967,-0.225281369123572,"NPL","N-acetylneuraminate pyruvate lyase",TRUE
+"223405_at",0.976446519373981,0.888293981292043,-0.142088791584018,-5.92985483531771,-0.0850052327125894,"NPL","N-acetylneuraminate pyruvate lyase",TRUE
+"217796_s_at",0.868771271118463,0.505088737573757,0.677521768844206,-5.71854366912757,0.205343468358119,"NPLOC4","NPL4 homolog, ubiquitin recognition factor",TRUE
+"200063_s_at",0.97689149311934,0.889694568813608,0.140294921352865,-5.93010132502442,0.0293896421232258,"NPM1","nucleophosmin",TRUE
+"221923_s_at",0.993213867476782,0.9674975185848,0.0412100824936196,-5.93885634946052,0.0128255398614581,"NPM1","nucleophosmin",TRUE
+"221691_x_at",0.996261754016157,0.981991967840639,0.022827806776594,-5.93942967107145,0.00597184881801915,"NPM1","nucleophosmin",TRUE
+"230977_at",0.735891397216012,0.221002958249418,1.2593688205906,-5.19537946795187,0.33900119784415,"NPM2","nucleophosmin/nucleoplasmin 2",TRUE
+"205129_at",0.812644903778517,0.361316632850023,0.932128853544216,-5.52512705633826,0.822309796008591,"NPM3","nucleophosmin/nucleoplasmin 3",TRUE
+"244747_at",0.74057407812241,0.229836673616482,-1.23480959756305,-5.22312524220577,-1.30342548579912,"NPNT","nephronectin",TRUE
+"225911_at",0.941106542715586,0.736087661602295,-0.341307515647068,-5.88310382474746,-0.587238854005452,"NPNT","nephronectin",TRUE
+"209957_s_at",0.774230543658252,0.289337584466044,1.08557484618941,-5.3814362680835,0.452596849450591,"NPPA","natriuretic peptide A",TRUE
+"206801_at",0.785175995766517,0.310695613505415,1.03749561768745,-5.42858328234682,0.686362675227934,"NPPB","natriuretic peptide B",TRUE
+"221348_at",0.886023097762234,0.548514298753024,-0.609313541997479,-5.76045496181487,-0.317567708912866,"NPPC","natriuretic peptide C",TRUE
+"204648_at",0.89961817630669,0.590580237564655,0.545913456030337,-5.79556143284286,0.390750766802618,"NPR1","natriuretic peptide receptor 1",TRUE
+"32625_at",0.938726197187622,0.7268880463311,0.353725875593905,-5.87892424281978,0.213824106071826,"NPR1","natriuretic peptide receptor 1",TRUE
+"204310_s_at",0.597654932724127,0.0741790394807827,1.87399633449637,-4.36021076089845,1.78491989685233,"NPR2","natriuretic peptide receptor 2",TRUE
+"214066_x_at",0.598790786356002,0.0757094734707727,1.86343518200776,-4.37664244707204,1.1725420733409,"NPR2","natriuretic peptide receptor 2",TRUE
+"219054_at",0.715493644680006,0.191184710404518,-1.34829989289237,-5.09102921890658,-1.44298140113819,"NPR3","natriuretic peptide receptor 3",TRUE
+"219789_at",0.865345395265289,0.495044141322222,-0.693757271803124,-5.70794059222218,-0.558028504112315,"NPR3","natriuretic peptide receptor 3",TRUE
+"219790_s_at",0.962741248200658,0.830379896423966,-0.21675858358223,-5.91682504370625,-0.267335006194799,"NPR3","natriuretic peptide receptor 3",TRUE
+"210373_at",0.899808883319249,0.593495922332233,-0.541604639132115,-5.79781167352013,-0.455580008371877,"NPRL2","NPR2-like, GATOR1 complex subunit",TRUE
+"203246_s_at",0.969882914559333,0.857232667783813,-0.182006308075821,-5.92356175107046,-0.187119678849207,"NPRL2","NPR2-like, GATOR1 complex subunit",TRUE
+"214273_x_at",0.5622227964382,0.0549111976768174,-2.02654964402418,-4.11575041847995,-0.696854167764471,"NPRL3","NPR3 like, GATOR1 complex subunit",TRUE
+"203289_s_at",0.586459015231188,0.0661056075650735,-1.93308502332025,-4.2670806989,-0.58065418701509,"NPRL3","NPR3 like, GATOR1 complex subunit",TRUE
+"210672_s_at",0.62282585384278,0.0933413908053261,-1.75350068755253,-4.54370775955689,-0.484409172062513,"NPRL3","NPR3 like, GATOR1 complex subunit",TRUE
+"229122_x_at",0.877651569534497,0.528244313676108,0.640770233286273,-5.74165653185648,0.329060298717165,"NPRL3","NPR3 like, GATOR1 complex subunit",TRUE
+"1555502_at",0.739340500562926,0.22690657552659,-1.24287470349507,-5.21406549681791,-1.17369644051578,"NPSA","novel prostate-specific antigen",TRUE
+"234117_at",0.830592576740524,0.403085769574791,0.852448884144787,-5.5918151434133,0.500448430852026,"NPSR1-AS1","NPSR1 antisense RNA 1",TRUE
+"1561490_at",0.851319596585235,0.454886083597321,0.76064878305946,-5.6617373545072,0.196482915841999,"NPSR1-AS1","NPSR1 antisense RNA 1",TRUE
+"202228_s_at",0.896159990898752,0.579086905774654,-0.56300169978109,-5.78646678335616,-0.198122618075738,"NPTN","neuroplastin",TRUE
+"228723_at",0.960614707352139,0.821025189932867,-0.228927410083545,-5.91418978187816,-0.104813045804345,"NPTN-IT1","NPTN intronic transcript 1",TRUE
+"204684_at",0.871744769522775,0.514326036790357,0.662750944609892,-5.72798145291886,0.638513048889973,"NPTX1","neuronal pentraxin 1",TRUE
+"213479_at",0.784789297644843,0.309365591808675,1.04041984925006,-5.42577053258052,0.745202513240172,"NPTX2","neuronal pentraxin 2",TRUE
+"213040_s_at",0.196284904197538,0.00212888794127371,-3.47573782458226,-1.3221628968544,-3.35861223208953,"NPTXR","neuronal pentraxin receptor",TRUE
+"217041_at",0.693988314656736,0.163362164887087,1.44173864327072,-4.97500754352524,0.464577326839787,"NPTXR","neuronal pentraxin receptor",TRUE
+"221322_at",0.9181984176728,0.652840129987259,0.455982812989534,-5.83891743425185,0.334257897865357,"NPVF","neuropeptide VF precursor",TRUE
+"243110_x_at",0.992583835836326,0.965333443638153,0.043955715317849,-5.93874246749922,0.0665058856604865,"NPW","neuropeptide W",TRUE
+"206001_at",0.499265335405817,0.0314392685789931,2.29692773290713,-3.65245953743163,1.42597307249583,"NPY","neuropeptide Y",TRUE
+"205440_s_at",0.517367684249416,0.0365801747871908,-2.22489229679298,-3.77937637647348,-4.84005436559943,"NPY1R","neuropeptide Y receptor Y1",TRUE
+"210730_s_at",0.527826453640453,0.0403812077934845,2.17734336711352,-3.8618097508586,0.85224803285888,"NPY2R","neuropeptide Y receptor Y2",TRUE
+"210729_at",0.914910510855952,0.641630873060991,-0.471873732592001,-5.83180973625155,-0.496962853598183,"NPY2R","neuropeptide Y receptor Y2",TRUE
+"208379_x_at",0.951920215149949,0.779706766255336,-0.283128506088897,-5.90071489250736,-0.219865167448411,"NPY2R","neuropeptide Y receptor Y2",TRUE
+"207400_at",0.849619613504567,0.450830621435656,-0.767595732605978,-5.65670815682971,-0.755208140724387,"NPY5R","neuropeptide Y receptor Y5",TRUE
+"210444_at",0.753862100951903,0.247128096759524,1.18873738209489,-5.27389987913229,0.638612498057721,"NPY6R","neuropeptide Y receptor Y6 (pseudogene)",TRUE
+"236860_at",0.92247975200053,0.668664218411144,-0.433749748598562,-5.84846112026571,-0.290653713683811,"NPY6R","neuropeptide Y receptor Y6 (pseudogene)",TRUE
+"201468_s_at",0.587626678796111,0.0666313057961983,-1.92904975749268,-4.27350450215972,-1.0778690329641,"NQO1","NAD(P)H quinone dehydrogenase 1",TRUE
+"210519_s_at",0.627092759817312,0.0982961374420823,-1.72584587191256,-4.58456171612644,-0.681073616008524,"NQO1","NAD(P)H quinone dehydrogenase 1",TRUE
+"201467_s_at",0.663129351367592,0.131132620802869,-1.56765883596352,-4.80872973680918,-0.912828109337065,"NQO1","NAD(P)H quinone dehydrogenase 1",TRUE
+"237870_at",0.715119690416591,0.1908595446706,1.34932760656743,-5.08978827563,0.800610017846023,"NQO2","NAD(P)H quinone dehydrogenase 2",TRUE
+"203814_s_at",0.988303954498837,0.944356542467523,0.0705910154628016,-5.93725669204558,0.032946545076328,"NQO2","NAD(P)H quinone dehydrogenase 2",TRUE
+"206644_at",0.767945391174396,0.270537835205985,1.13005660581977,-5.33612444206846,0.69300771282613,"NR0B1","nuclear receptor subfamily 0 group B member 1",TRUE
+"206645_s_at",0.950340142951297,0.774399406925084,0.290150328970463,-5.89876197498389,0.325842087077686,"NR0B1","nuclear receptor subfamily 0 group B member 1",TRUE
+"206410_at",0.852006864319744,0.457291271993406,0.756546343859801,-5.66468698310991,0.477106293388546,"NR0B2","nuclear receptor subfamily 0 group B member 2",TRUE
+"217476_at",0.864894115958506,0.493552540194558,0.696184138004624,-5.70633505783644,0.344192040530911,"NR1D1///THRA","nuclear receptor subfamily 1 group D member 1///thyroid hormone receptor, alpha",TRUE
+"31637_s_at",0.900867933475689,0.596775132973669,0.536770957586603,-5.80031538830307,0.170450200377532,"NR1D1///THRA","nuclear receptor subfamily 1 group D member 1///thyroid hormone receptor, alpha",TRUE
+"204760_s_at",0.95168059103032,0.778158769801128,-0.285175042617041,-5.9001506083641,-0.192197917468266,"NR1D1///THRA","nuclear receptor subfamily 1 group D member 1///thyroid hormone receptor, alpha",TRUE
+"225768_at",0.853093296743962,0.459480015184422,0.752824329142468,-5.66735002956488,0.282131496199316,"NR1D2","nuclear receptor subfamily 1 group D member 2",TRUE
+"209750_at",0.94960065125426,0.772065750692718,0.293242537881805,-5.89788691612134,0.138256552008853,"NR1D2","nuclear receptor subfamily 1 group D member 2",TRUE
+"218215_s_at",0.952697366942815,0.783573390858609,0.278021984313757,-5.90210530779914,0.0934735784941747,"NR1H2","nuclear receptor subfamily 1 group H member 2",TRUE
+"203920_at",0.772988605474261,0.283632448566112,1.09884629476357,-5.36808634533845,0.508517249473801,"NR1H3","nuclear receptor subfamily 1 group H member 3",TRUE
+"1554375_a_at",0.767011109525761,0.268141753040245,1.13588634996647,-5.3300665834112,0.794837940423571,"NR1H4","nuclear receptor subfamily 1 group H member 4",TRUE
+"206340_at",0.839466826665106,0.425878152827759,-0.811202450795735,-5.62415589600107,-0.497226230695995,"NR1H4","nuclear receptor subfamily 1 group H member 4",TRUE
+"243800_at",0.913627134030439,0.637739517324693,-0.477419102965807,-5.82927330924108,-0.338014079472432,"NR1H4","nuclear receptor subfamily 1 group H member 4",TRUE
+"207202_s_at",0.863559206655094,0.488650834603944,0.704189055257289,-5.70100136030819,0.344464858050807,"NR1I2","nuclear receptor subfamily 1 group I member 2",TRUE
+"207203_s_at",0.984244246588495,0.92337103093843,0.0972897240536509,-5.93507433809961,0.0655488643694326,"NR1I2","nuclear receptor subfamily 1 group I member 2",TRUE
+"1570188_at",0.712948021516228,0.187163238840005,1.36110810168648,-5.07550711914842,0.73656850710854,"NR1I3","nuclear receptor subfamily 1 group I member 3",TRUE
+"207007_at",0.971352228387114,0.863957180913861,-0.173341082022093,-5.92505921901287,-0.0951578329196918,"NR1I3","nuclear receptor subfamily 1 group I member 3",TRUE
+"229956_at",0.848364007856994,0.448321252249384,0.77191319016873,-5.65356080198019,0.382357447119179,"NR2C1","nuclear receptor subfamily 2 group C member 1",TRUE
+"210531_at",0.861665593344139,0.48361988713118,-0.71245329242827,-5.69543391676175,-0.206303154067553,"NR2C1","nuclear receptor subfamily 2 group C member 1",TRUE
+"204791_at",0.939976205834042,0.730372773396174,-0.349015352649264,-5.88052701604261,-0.107722804970933,"NR2C1","nuclear receptor subfamily 2 group C member 1",TRUE
+"210530_s_at",0.986342822130003,0.934079029193616,-0.0836587265250459,-5.93627520666359,-0.0252846147658916,"NR2C1","nuclear receptor subfamily 2 group C member 1",TRUE
+"206038_s_at",0.952613441433926,0.782951709152361,0.278842505713979,-5.90188358795578,0.0878503443733392,"NR2C2","nuclear receptor subfamily 2 group C member 2",TRUE
+"225477_s_at",0.99186228645105,0.962324287447852,0.0477741107188228,-5.93857188572938,0.0122317450373366,"NR2C2","nuclear receptor subfamily 2 group C member 2",TRUE
+"226839_at",0.702888118552354,0.174804535031466,-1.40188281810365,-5.02528100507177,-0.560210530953578,"NR2C2AP","nuclear receptor 2C2 associated protein",TRUE
+"207443_at",0.69533015659068,0.164761193919213,1.43674756522512,-4.98136640653862,0.648939159166259,"NR2E1","nuclear receptor subfamily 2 group E member 1",TRUE
+"208388_at",0.863865128741987,0.48995490420395,0.70205490778306,-5.70242903308572,0.459845568460382,"NR2E3","nuclear receptor subfamily 2 group E member 3",TRUE
+"208385_at",0.865854896594418,0.496130347739865,0.691992618417437,-5.70910466794114,0.472885700944374,"NR2E3","nuclear receptor subfamily 2 group E member 3",TRUE
+"209505_at",0.922253982025599,0.668290452928618,0.434272296547512,-5.8482421854394,0.576851706444113,"NR2F1","nuclear receptor subfamily 2 group F member 1",TRUE
+"1556695_a_at",0.846758911329672,0.445248722027029,0.777219615188223,-5.64966968453282,0.816866312222432,"NR2F1-AS1","NR2F1 antisense RNA 1",TRUE
+"229014_at",0.867692227847244,0.500470532624339,0.684963411590353,-5.71371346670026,0.430700987592507,"NR2F1-AS1","NR2F1 antisense RNA 1",TRUE
+"1556696_s_at",0.940227139261806,0.732560923839991,0.346061608933078,-5.88152120531012,0.430466229028526,"NR2F1-AS1","NR2F1 antisense RNA 1",TRUE
+"242396_at",0.446963972064621,0.0210928154278602,2.48260354506443,-3.31479479832561,2.39781551315173,"NR2F2","nuclear receptor subfamily 2 group F member 2",TRUE
+"209119_x_at",0.851319596585235,0.455163190404327,0.760175468560614,-5.66207843457693,0.537198129380515,"NR2F2","nuclear receptor subfamily 2 group F member 2",TRUE
+"209121_x_at",0.874480604680453,0.520836132597584,0.652429526247115,-5.73445794295403,0.743616207604058,"NR2F2","nuclear receptor subfamily 2 group F member 2",TRUE
+"209120_at",0.900279385985816,0.595183367102575,0.539115658196596,-5.79910362309706,0.763523404220749,"NR2F2","nuclear receptor subfamily 2 group F member 2",TRUE
+"215073_s_at",0.913895480987494,0.638698890347695,0.476050545371731,-5.8299019760222,0.546008349107723,"NR2F2","nuclear receptor subfamily 2 group F member 2",TRUE
+"229092_at",0.994536266629158,0.974742085748498,-0.0320209014856593,-5.93918408868864,-0.0215125532382556,"NR2F2","nuclear receptor subfamily 2 group F member 2",TRUE
+"232878_at",0.68747436517451,0.156148162010535,1.46803638211795,-4.94120688202331,0.827813804194833,"NR2F2-AS1","NR2F2 antisense RNA 1",TRUE
+"209506_s_at",0.926430328514448,0.680285296774102,0.417562956742764,-5.85511470473108,0.270258718121547,"NR2F2///NR2F1","nuclear receptor subfamily 2 group F member 2///nuclear receptor subfamily 2 group F member 1",TRUE
+"209262_s_at",0.595927404748624,0.0722816000341197,-1.88735756471001,-4.33932885257476,-0.995736928662708,"NR2F6","nuclear receptor subfamily 2 group F member 6",TRUE
+"213354_s_at",0.900692252557887,0.595997534887049,-0.537915992802437,-5.79972426408146,-0.173697743211927,"NR2F6","nuclear receptor subfamily 2 group F member 6",TRUE
+"209261_s_at",0.92051722798026,0.661946050560481,-0.44316109197657,-5.84447836119216,-0.280538419952236,"NR2F6","nuclear receptor subfamily 2 group F member 6",TRUE
+"201866_s_at",0.517654151778308,0.036812502398717,2.22186001709673,-3.78466567861464,1.45178760858619,"NR3C1","nuclear receptor subfamily 3 group C member 1",TRUE
+"201865_x_at",0.533225267583674,0.0421216265330386,2.1569133921265,-3.89689035759044,1.79091158862089,"NR3C1","nuclear receptor subfamily 3 group C member 1",TRUE
+"211671_s_at",0.564004192185035,0.0559459176997303,2.01723388752917,-4.13104874443852,1.8782181280895,"NR3C1","nuclear receptor subfamily 3 group C member 1",TRUE
+"216321_s_at",0.614178202960275,0.08519658042688,1.8018270760054,-4.4711725211465,1.99658737514837,"NR3C1","nuclear receptor subfamily 3 group C member 1",TRUE
+"232431_at",0.660234446131062,0.128277391474564,1.5800033152735,-4.79183559498577,1.9024244917517,"NR3C1","nuclear receptor subfamily 3 group C member 1",TRUE
+"205259_at",0.701946399633291,0.173512676562303,-1.40627610074731,-5.01979621487758,-1.56187666356344,"NR3C2","nuclear receptor subfamily 3 group C member 2",TRUE
+"202340_x_at",0.634844920112955,0.105766847321608,-1.68631638417027,-4.64211456994271,-1.10702436488884,"NR4A1","nuclear receptor subfamily 4 group A member 1",TRUE
+"211143_x_at",0.822232806605564,0.38689504836238,-0.882662543352538,-5.56717729823789,-0.434742801353152,"NR4A1","nuclear receptor subfamily 4 group A member 1",TRUE
+"210226_at",0.975196332002567,0.879247607255621,-0.153687152555739,-5.92818571969516,-0.0899388776329264,"NR4A1","nuclear receptor subfamily 4 group A member 1",TRUE
+"216248_s_at",0.961395512423249,0.824829556788652,-0.223974439230196,-5.91527967204958,-0.226930272703108,"NR4A2","nuclear receptor subfamily 4 group A member 2",TRUE
+"204622_x_at",0.969882914559333,0.856519880760083,-0.182925632075167,-5.92339860775263,-0.151444121262289,"NR4A2","nuclear receptor subfamily 4 group A member 2",TRUE
+"204621_s_at",0.997743187447018,0.988874359114155,0.0141025806886105,-5.93958661274293,0.0111541580658727,"NR4A2","nuclear receptor subfamily 4 group A member 2",TRUE
+"216979_at",0.855439520086837,0.468582111587178,0.737458425222678,-5.67821236215473,0.274457713600538,"NR4A3","nuclear receptor subfamily 4 group A member 3",TRUE
+"207978_s_at",0.972309558036541,0.86669371047954,-0.169818706047823,-5.9256471162618,-0.110803133816923,"NR4A3","nuclear receptor subfamily 4 group A member 3",TRUE
+"209959_at",0.988403345042769,0.94459122943656,0.0702927702438382,-5.93727715252948,0.0270980827767753,"NR4A3","nuclear receptor subfamily 4 group A member 3",TRUE
+"210333_at",0.652990855994716,0.122273806743007,-1.60672348699555,-4.75491352739328,-1.03217019329219,"NR5A1","nuclear receptor subfamily 5 group A member 1",TRUE
+"1560469_at",0.65231718901428,0.121372158460764,1.61083048294999,-4.74919581157163,1.73509622918076,"NR5A2","nuclear receptor subfamily 5 group A member 2",TRUE
+"208343_s_at",0.870852305833096,0.510613319074484,0.668669757607813,-5.72422355980949,0.980730078215956,"NR5A2","nuclear receptor subfamily 5 group A member 2",TRUE
+"210174_at",0.929385267595748,0.689521426515847,0.404778758580075,-5.86019377203998,0.342026602472287,"NR5A2","nuclear receptor subfamily 5 group A member 2",TRUE
+"208337_s_at",0.973493137611142,0.872063372594356,0.162913386140011,-5.92676471132672,0.183518974447451,"NR5A2","nuclear receptor subfamily 5 group A member 2",TRUE
+"210392_x_at",0.677509122383198,0.144959487541669,1.51084443740251,-4.88513175732433,0.784678214036811,"NR6A1","nuclear receptor subfamily 6 group A member 1",TRUE
+"211402_x_at",0.687949239097856,0.157255291438403,1.46393749501132,-4.94650783242647,0.93828799630773,"NR6A1","nuclear receptor subfamily 6 group A member 1",TRUE
+"210391_at",0.791211889207316,0.321622213035153,-1.01379901024992,-5.4511128823805,-0.303555773560789,"NR6A1","nuclear receptor subfamily 6 group A member 1",TRUE
+"228894_at",0.812302873476553,0.35694330944015,0.940817684518989,-5.51752296841013,0.549685132425688,"NR6A1","nuclear receptor subfamily 6 group A member 1",TRUE
+"227496_at",0.924307191583469,0.673581998014663,0.426885732337101,-5.8513129366122,0.183034716907885,"NR6A1","nuclear receptor subfamily 6 group A member 1",TRUE
+"207742_s_at",0.932742319779223,0.702998871410209,-0.386245658925513,-5.86728069600492,-0.204819828318286,"NR6A1","nuclear receptor subfamily 6 group A member 1",TRUE
+"227494_at",0.968262726161738,0.850612835317673,-0.19055059220155,-5.9220139064998,-0.0636463560045142,"NR6A1","nuclear receptor subfamily 6 group A member 1",TRUE
+"235312_s_at",0.755719147268412,0.250045365316201,1.18120531239232,-5.28204102307407,0.74210038553197,"NRAP","nebulin related anchoring protein",TRUE
+"207089_at",0.888232641270866,0.553937204617382,-0.60100310286016,-5.76526890505053,-0.739466828530364,"NRAP","nebulin related anchoring protein",TRUE
+"235313_at",0.930409774479405,0.692282501487047,0.400970397823704,-5.86167675869157,0.157955943344706,"NRAP","nebulin related anchoring protein",TRUE
+"226499_at",0.919176489727468,0.655802951136893,-0.451802549987703,-5.84074754843028,-0.377818173135692,"NRARP","NOTCH-regulated ankyrin repeat protein",TRUE
+"202647_s_at",0.859947009633611,0.478448320292458,0.721000668020498,-5.689610687577,0.892100165416277,"NRAS","neuroblastoma RAS viral oncogene homolog",TRUE
+"224985_at",0.892327842300455,0.564594227280145,0.584794342683401,-5.77447425188689,0.603032679062835,"NRAS","neuroblastoma RAS viral oncogene homolog",TRUE
+"238854_at",0.801560848966415,0.338527721889748,-0.978217054545742,-5.48405570610316,-0.328860076505137,"NRAV","negative regulator of antiviral response (non-protein coding)",TRUE
+"227437_at",0.859064198633089,0.475821934271406,-0.725362106516318,-5.68661384283684,-0.272029596014491,"NRAV","negative regulator of antiviral response (non-protein coding)",TRUE
+"221803_s_at",0.95915232180739,0.814860380946233,-0.236965990324902,-5.91237043192174,-0.0650715021449582,"NRBF2","nuclear receptor binding factor 2",TRUE
+"223650_s_at",0.975196332002567,0.879337466360249,0.153571840644204,-5.92820295703428,0.0448410010077005,"NRBF2","nuclear receptor binding factor 2",TRUE
+"217765_at",0.943824539742785,0.748412311141446,0.324755701874771,-5.88844489992791,0.141737777847567,"NRBP1","nuclear receptor binding protein 1",TRUE
+"204105_s_at",0.982909728377256,0.916918129442414,-0.105513055581714,-5.93426245889476,-0.153638634986193,"NRCAM","neuronal cell adhesion molecule",TRUE
+"216959_x_at",0.998347572104896,0.99210674003419,0.0100051243278695,-5.93963472462345,0.00899242163062475,"NRCAM","neuronal cell adhesion molecule",TRUE
+"208709_s_at",0.695812999227098,0.165736712352254,-1.43328751791768,-4.98576409121746,-0.353459674358964,"NRDC","nardilysin convertase",TRUE
+"229422_at",0.936626652549144,0.717078281647089,0.367030669767398,-5.87428261844805,0.164952120074012,"NRDC","nardilysin convertase",TRUE
+"235212_at",0.692406993106627,0.161947885282991,-1.44681925180309,-4.96851614407804,-1.13939012622197,"NRDE2","NRDE-2, necessary for RNA interference, domain containing",TRUE
+"221231_s_at",0.894729774938685,0.571817604201327,-0.573897464741797,-5.78052596569379,-0.346989426267062,"NRDE2","NRDE-2, necessary for RNA interference, domain containing",TRUE
+"227575_s_at",0.942303845415102,0.740759610012185,-0.33502196766023,-5.88516302485139,-0.134710092689962,"NRDE2","NRDE-2, necessary for RNA interference, domain containing",TRUE
+"201309_x_at",0.773234064853267,0.284544780622073,-1.09671112941234,-5.37024388226193,-0.898354305578236,"NREP","neuronal regeneration related protein",TRUE
+"201310_s_at",0.803794790259171,0.342358863757076,-0.970324462675106,-5.49121770566075,-0.843822944322609,"NREP","neuronal regeneration related protein",TRUE
+"238411_x_at",0.851319596585235,0.454859875549519,-0.760693556908784,-5.66170507916604,-0.512591968718626,"NREP","neuronal regeneration related protein",TRUE
+"230424_at",0.945600017341598,0.754612161987171,0.316464545659427,-5.89102157837247,0.197959010789793,"NREP","neuronal regeneration related protein",TRUE
+"211279_at",0.679482812809504,0.146783454610089,1.50368612652702,-4.89459866267311,0.498963404204945,"NRF1","nuclear respiratory factor 1",TRUE
+"243189_at",0.870980161749509,0.511259274555408,0.66763825546141,-5.72488077018364,0.592068109117415,"NRF1","nuclear respiratory factor 1",TRUE
+"204652_s_at",0.935229311206739,0.711734482121747,-0.374306704602466,-5.87167269385777,-0.104367908204853,"NRF1","nuclear respiratory factor 1",TRUE
+"204651_at",0.971216837324271,0.863080460796492,0.174470041718546,-5.92486824490378,0.0410536986417629,"NRF1","nuclear respiratory factor 1",TRUE
+"211280_s_at",0.979588787486838,0.902684198576362,0.123679459672506,-5.93223581187029,0.0417686721166799,"NRF1","nuclear respiratory factor 1",TRUE
+"208232_x_at",0.638134354959023,0.109479909940739,1.66754442027337,-4.66909305709366,0.805227723872928,"NRG1","neuregulin 1",TRUE
+"208231_at",0.691295036264984,0.160906429002173,1.45058346969991,-4.96369467785514,1.04790333848332,"NRG1","neuregulin 1",TRUE
+"208241_at",0.71100904734581,0.184725807362546,1.36897724205441,-5.06590989367342,0.77726116459178,"NRG1","neuregulin 1",TRUE
+"206237_s_at",0.743869497380606,0.2346578937444,1.22170756095831,-5.23773461569907,1.18790350911306,"NRG1","neuregulin 1",TRUE
+"206343_s_at",0.745717401914776,0.237388411162811,1.21437737426517,-5.24584932521459,2.2709012154251,"NRG1","neuregulin 1",TRUE
+"208230_s_at",0.901788521024914,0.599557190673118,0.5326802239425,-5.80241722062273,0.540984016698006,"NRG1","neuregulin 1",TRUE
+"1563168_at",0.988776423002819,0.9459900554989,-0.0685152467297266,-5.93739729991464,-0.0516244243006039,"NRG1-IT1","NRG1 intronic transcript 1",TRUE
+"206879_s_at",0.622434989367596,0.0930518744629512,-1.75515516799209,-4.54124840374389,-1.11625001432955,"NRG2","neuregulin 2",TRUE
+"208062_s_at",0.828615904006271,0.399251163697142,-0.859532878680418,-5.5861101116423,-0.667861806328108,"NRG2","neuregulin 2",TRUE
+"242303_at",0.994098505325585,0.97269131814923,-0.0346218218931104,-5.93909966938258,-0.012580180058805,"NRG2","neuregulin 2",TRUE
+"229233_at",0.9116561917482,0.630740846286658,-0.487431047607007,-5.82462050025118,-0.486695652919076,"NRG3","neuregulin 3",TRUE
+"242426_at",0.610033432202476,0.0824702289321915,1.81889597105796,-4.44521094571791,1.65747121420167,"NRG4","neuregulin 4",TRUE
+"204081_at",0.787465928140783,0.313286856313092,-1.0318236730989,-5.43401865440408,-0.632114439070961,"NRGN","neurogranin",TRUE
+"202599_s_at",0.914488991533795,0.639821897009685,0.47444973312363,-5.83063509170311,0.303466652881319,"NRIP1","nuclear receptor interacting protein 1",TRUE
+"202600_s_at",0.923124080520773,0.670494581327606,0.43119255274961,-5.84952878956207,0.300236161711933,"NRIP1","nuclear receptor interacting protein 1",TRUE
+"215104_at",0.451020270465914,0.0215820909270168,2.47208417406343,-3.33430700454356,1.46552016557795,"NRIP2","nuclear receptor interacting protein 2",TRUE
+"219557_s_at",0.728262401376535,0.208501095558153,1.29544671499292,-5.15377391079893,0.90085780333217,"NRIP3","nuclear receptor interacting protein 3",TRUE
+"222900_at",0.813631136157676,0.364425306089832,0.925995392028877,-5.53045574193652,0.721683275840996,"NRIP3","nuclear receptor interacting protein 3",TRUE
+"227971_at",0.88113080359582,0.537666349271222,-0.626069231109841,-5.75055519535412,-0.759902056919624,"NRK","Nik related kinase",TRUE
+"232771_at",0.980475222305516,0.908959260960214,-0.115665872889276,-5.93316936089851,-0.135702924826261,"NRK","Nik related kinase",TRUE
+"206596_s_at",0.837357147033741,0.42026369404212,-0.821230885596509,-5.61643084709752,-0.591786229529355,"NRL","neural retina leucine zipper",TRUE
+"206597_at",0.907199422920875,0.61623190430468,-0.508350340608588,-5.81459440000614,-0.381677747643472,"NRL","neural retina leucine zipper",TRUE
+"225592_at",0.528176582660474,0.0408144889202518,2.17218385609174,-3.87068861051706,0.746389076630763,"NRM","nurim (nuclear envelope membrane protein)",TRUE
+"218625_at",0.69450946988669,0.163954510907731,1.43962124643513,-4.97770740302957,1.35240080040351,"NRN1","neuritin 1",TRUE
+"210615_at",0.755049574909504,0.249013043626886,1.18386310952995,-5.27917345958154,0.963339283464504,"NRP1","neuropilin 1",TRUE
+"212298_at",0.806422472374043,0.34740694859256,0.96001643375902,-5.50049176154525,1.65977672047321,"NRP1","neuropilin 1",TRUE
+"210510_s_at",0.937113154905832,0.719747399401222,0.363404009882138,-5.87556462193166,0.742765533142506,"NRP1","neuropilin 1",TRUE
+"1561365_at",0.977874971442423,0.892801771115452,0.136316895192356,-5.93063678040774,0.120354057404757,"NRP1","neuropilin 1",TRUE
+"214632_at",0.456898036702485,0.0224361043712281,2.45424308472629,-3.36729930326426,2.4272649777722,"NRP2","neuropilin 2",TRUE
+"229225_at",0.506114211039982,0.0331708682967286,2.27153431008015,-3.69747294293309,2.48334055746143,"NRP2","neuropilin 2",TRUE
+"222877_at",0.525243770035611,0.0392140932700223,2.1914950710762,-3.8373897240955,2.87788290855025,"NRP2","neuropilin 2",TRUE
+"223510_at",0.526161637688503,0.0395042253810938,2.18794180548182,-3.84353036765109,1.15696581609451,"NRP2","neuropilin 2",TRUE
+"225566_at",0.532405994061663,0.0419094774228949,2.15936239987778,-3.89269599705476,2.86259893385464,"NRP2","neuropilin 2",TRUE
+"219367_s_at",0.562894650172193,0.0555028317295138,2.02120412730117,-4.12453454179779,1.50374937548911,"NRP2","neuropilin 2",TRUE
+"1555468_at",0.682825347106105,0.150859415287163,1.48794856197801,-4.91528483511014,0.661366249511082,"NRP2","neuropilin 2",TRUE
+"210841_s_at",0.738877082146899,0.22555384433902,1.24662489231268,-5.20983552914116,0.796670423532211,"NRP2","neuropilin 2",TRUE
+"211844_s_at",0.740476003158683,0.229036498334241,1.23700428029293,-5.22066492822376,1.39452087239609,"NRP2","neuropilin 2",TRUE
+"228699_at",0.760337658876104,0.259050204106887,1.15836135130607,-5.30645537096308,0.762472735826885,"NRP2","neuropilin 2",TRUE
+"210842_at",0.898609426925686,0.5880914627141,-0.549599666548242,-5.79362259277254,-0.472759712092862,"NRP2","neuropilin 2",TRUE
+"235359_at",0.916270722105221,0.646458950255307,0.465014275613911,-5.83490708594994,0.359159698997583,"NRROS","negative regulator of reactive oxygen species",TRUE
+"239293_at",0.929385267595748,0.689482025396746,0.40483314865456,-5.86017249243865,0.240072711521744,"NRSN1","neurensin 1",TRUE
+"218359_at",0.8017109011727,0.339034656985359,-0.977169208676537,-5.48500960165328,-0.736097751307803,"NRSN2","neurensin 2",TRUE
+"240549_at",0.85334340854827,0.461298214007028,-0.749740497902212,-5.66954704621147,-0.353196429108704,"NRSN2-AS1","NRSN2 antisense RNA 1",TRUE
+"210683_at",0.839466826665106,0.425703333680199,-0.81151345851371,-5.62391765977941,-1.26381348208372,"NRTN","neurturin",TRUE
+"209915_s_at",0.842168961429806,0.435524963592643,0.794162031349163,-5.63707795988326,0.500338374479794,"NRXN1","neurexin 1",TRUE
+"216096_s_at",0.862649761550751,0.4863025322454,0.708040413596478,-5.69841448041889,0.443109559860429,"NRXN1","neurexin 1",TRUE
+"209914_s_at",0.919959462096257,0.659393551607812,0.4467474760464,-5.84293857521411,0.293324353344785,"NRXN1","neurexin 1",TRUE
+"1558708_at",0.957575623345388,0.809635224801292,-0.243791813468213,-5.91077654194407,-0.231558454598525,"NRXN1","neurexin 1",TRUE
+"237535_x_at",0.958933497686198,0.814219206979357,-0.237802954725854,-5.91217741456278,-0.149608663850105,"NRXN1","neurexin 1",TRUE
+"228547_at",0.959357995170594,0.816381866727278,-0.234980591120124,-5.91282558941813,-0.173096933429044,"NRXN1","neurexin 1",TRUE
+"209983_s_at",0.744573608322482,0.235671932263927,1.21897784221968,-5.24076142435392,0.536511923161069,"NRXN2","neurexin 2",TRUE
+"209982_s_at",0.918141489589102,0.652432142085888,0.45655909082088,-5.83866384473027,0.309260094539688,"NRXN2","neurexin 2",TRUE
+"229649_at",0.398650588126476,0.0138755024314084,-2.67197213980137,-2.95640590633121,-3.68394838044217,"NRXN3","neurexin 3",TRUE
+"215021_s_at",0.554387890519539,0.0507997691629074,-2.06518382066057,-4.05181038000048,-1.82166491723954,"NRXN3","neurexin 3",TRUE
+"215020_at",0.806649582904638,0.34764271784089,-0.959537501025916,-5.50092045271026,-0.997119563131524,"NRXN3","neurexin 3",TRUE
+"205795_at",0.835952408568777,0.416894806950887,-0.827288723119509,-5.61172133259052,-1.07794615430084,"NRXN3","neurexin 3",TRUE
+"201922_at",0.90427866743639,0.606711836974178,-0.522201931082196,-5.80772961063305,-0.157341411050862,"NSA2","NSA2, ribosome biogenesis homolog",TRUE
+"1555366_at",0.972659629123427,0.867767382101384,0.168437312225284,-5.92587439033139,0.10995633322188,"NSAP11","nervous system abundant protein 11",TRUE
+"235760_at",0.638360409116684,0.109601902657277,-1.66693685616718,-4.66996240058968,-0.801937992466442,"NSD1","nuclear receptor binding SET domain protein 1",TRUE
+"243612_at",0.698955864196462,0.170261499795579,-1.41744932155907,-5.00578337182059,-0.518850324152607,"NSD1","nuclear receptor binding SET domain protein 1",TRUE
+"219084_at",0.782206338814045,0.304149558465267,-1.05197454823505,-5.41458669175299,-0.43845631863481,"NSD1","nuclear receptor binding SET domain protein 1",TRUE
+"225654_at",0.909934011695618,0.625079314957032,-0.495567230269603,-5.82076990927379,-0.162713669967405,"NSD1","nuclear receptor binding SET domain protein 1",TRUE
+"215093_at",0.843475287501313,0.438618352504892,-0.78874725012201,-5.64113006782155,-0.318135554088908,"NSDHL","NAD(P) dependent steroid dehydrogenase-like",TRUE
+"209279_s_at",0.891900876166289,0.561926099337909,-0.588837441699609,-5.77220085447701,-0.236021315836092,"NSDHL","NAD(P) dependent steroid dehydrogenase-like",TRUE
+"1566784_at",0.831875452294783,0.407356158457191,0.844610432124913,-5.5980764685161,0.488237583196566,"NSF","N-ethylmaleimide sensitive factor, vesicle fusing ATPase",TRUE
+"1566785_x_at",0.865345395265289,0.49475894146289,-0.694220974439424,-5.70763423543672,-0.21869398319923,"NSF","N-ethylmaleimide sensitive factor, vesicle fusing ATPase",TRUE
+"232519_at",0.769258076576208,0.276288386762511,1.11621793152873,-5.35039424455977,0.720516164207289,"NSFL1C","NSFL1 cofactor",TRUE
+"236951_at",0.936456142259101,0.71651954742144,0.367790482626208,-5.87401243676607,0.298848285883222,"NSFL1C","NSFL1 cofactor",TRUE
+"220248_x_at",0.94079969729523,0.735071280635664,0.342676784552185,-5.8826502196437,0.164526013788473,"NSFL1C","NSFL1 cofactor",TRUE
+"232520_s_at",0.945272089973488,0.752982255217774,0.318642029092817,-5.89035126118147,0.166126159798361,"NSFL1C","NSFL1 cofactor",TRUE
+"217830_s_at",0.987492202135276,0.941161978640181,0.0746513997038045,-5.93696952448284,0.034164426868049,"NSFL1C","NSFL1 cofactor",TRUE
+"217831_s_at",0.989654520357877,0.9501454141922,0.0632362387063861,-5.93773598971762,0.0351161603978429,"NSFL1C","NSFL1 cofactor",TRUE
+"213533_at",0.872737878403454,0.51700241689272,-0.658498982645461,-5.73066128470583,-0.712911522023909,"NSG1","neuron specific gene family member 1",TRUE
+"209569_x_at",0.952952008650351,0.784514364176697,0.276780419090998,-5.90243956821663,0.204914732193235,"NSG1","neuron specific gene family member 1",TRUE
+"209570_s_at",0.955561357825402,0.796432209896727,-0.261093117742546,-5.90653500966197,-0.19373572797932,"NSG1","neuron specific gene family member 1",TRUE
+"209484_s_at",0.819238566204338,0.376138010561088,-0.903194135701791,-5.54998086566556,-0.343859140022317,"NSL1","NSL1, MIS12 kinetochore complex component",TRUE
+"235799_at",0.91671872326659,0.647934276955173,-0.462922739936263,-5.8358426712137,-0.128432759661269,"NSL1","NSL1, MIS12 kinetochore complex component",TRUE
+"209483_s_at",0.937842878751575,0.724854804424204,0.356478101510488,-5.87797796232819,0.221360675155565,"NSL1","NSL1, MIS12 kinetochore complex component",TRUE
+"230592_at",0.948109877411639,0.764124003321489,0.303787851798688,-5.89483355047042,0.107057839670194,"NSL1","NSL1, MIS12 kinetochore complex component",TRUE
+"240056_at",0.62986301194198,0.101162235175822,1.71038788271528,-4.60718674263175,0.953428770871448,"NSMAF","neutral sphingomyelinase activation associated factor",TRUE
+"232148_at",0.90496994347229,0.610603318589598,0.516527516154716,-5.81056357470146,0.296300523333511,"NSMAF","neutral sphingomyelinase activation associated factor",TRUE
+"203269_at",0.972405051071295,0.866885941224308,0.169571355774444,-5.92568794766972,0.124604064905839,"NSMAF","neutral sphingomyelinase activation associated factor",TRUE
+"1558775_s_at",0.986125157570823,0.931836420043833,-0.0865120760751618,-5.93603879237579,-0.0729516079320467,"NSMAF","neutral sphingomyelinase activation associated factor",TRUE
+"232149_s_at",0.990810941805126,0.956009860252014,0.0557890856370931,-5.93816764840635,0.0568309755025638,"NSMAF","neutral sphingomyelinase activation associated factor",TRUE
+"224666_at",0.767965891104819,0.270757576350936,-1.12952386623963,-5.3366766549562,-0.447571674407676,"NSMCE1","NSE1 homolog, SMC5-SMC6 complex component",TRUE
+"226536_at",0.883515015273005,0.541708561488535,0.619804781795778,-5.75428671144214,0.317365353306743,"NSMCE2","NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase",TRUE
+"226008_at",0.827866702343255,0.397107732807484,-0.863511691004989,-5.58288653492543,-0.325423533757972,"NSMCE3","NSE3 homolog, SMC5-SMC6 complex component",TRUE
+"211376_s_at",0.895758940460776,0.576517325462953,0.566845244909107,-5.78438372610388,0.210239909173655,"NSMCE4A","NSE4 homolog A, SMC5-SMC6 complex component",TRUE
+"228506_at",0.902212740485572,0.60076763809876,-0.530903255532923,-5.80332535888701,-0.260722853818436,"NSMCE4A","NSE4 homolog A, SMC5-SMC6 complex component",TRUE
+"227387_at",0.92523595026689,0.676171062913838,0.42328041262671,-5.85279294704634,0.262307397213869,"NSMCE4A","NSE4 homolog A, SMC5-SMC6 complex component",TRUE
+"219067_s_at",0.987191064227113,0.940300617152621,0.0757464326367607,-5.93688933163252,0.0384788525746931,"NSMCE4A","NSE4 homolog A, SMC5-SMC6 complex component",TRUE
+"230189_x_at",0.773156930607264,0.284077724352434,1.09780357917744,-5.36914045247504,0.458311925283815,"NSMF","NMDA receptor synaptonuclear signaling and neuronal migration factor",TRUE
+"223236_at",0.96148769833346,0.825393445065921,0.223240793709899,-5.91543909196773,0.0833155462858315,"NSRP1","nuclear speckle splicing regulatory protein 1",TRUE
+"223076_s_at",0.860561098143874,0.480011121365955,0.718412079686426,-5.69138123817241,0.308421088396562,"NSUN2","NOP2/Sun RNA methyltransferase family member 2",TRUE
+"1568913_at",0.740610299769501,0.230338939979479,1.23343497092866,-5.22466432740505,0.856162471044758,"NSUN3","NOP2/Sun RNA methyltransferase family member 3",TRUE
+"219458_s_at",0.85334340854827,0.461587059529893,0.749251258532865,-5.66989481053716,0.263242670025972,"NSUN3","NOP2/Sun RNA methyltransferase family member 3",TRUE
+"222886_at",0.935259793487171,0.712114589901617,0.373788479963611,-5.87186025381175,0.158153502783518,"NSUN3","NOP2/Sun RNA methyltransferase family member 3",TRUE
+"236247_at",0.818768038148976,0.372452536451456,-0.910317265655205,-5.5439294296122,-0.259405329353886,"NSUN4","NOP2/Sun RNA methyltransferase family member 4",TRUE
+"230023_at",0.903615659612912,0.605004314789874,-0.524697256248527,-5.80647382706234,-0.137275205835047,"NSUN4","NOP2/Sun RNA methyltransferase family member 4",TRUE
+"226351_at",0.976422537443518,0.887926637180165,-0.142559364126297,-5.92978965801558,-0.0449027380559581,"NSUN4","NOP2/Sun RNA methyltransferase family member 4",TRUE
+"1559848_at",0.987977863996795,0.942554002661671,-0.0728819423976552,-5.93709664089204,-0.0403797853861461,"NSUN4","NOP2/Sun RNA methyltransferase family member 4",TRUE
+"213773_x_at",0.796963640275795,0.329935218057617,-0.996144507520923,-5.46759154080528,-0.320638482655307,"NSUN5","NOP2/Sun RNA methyltransferase family member 5",TRUE
+"203802_x_at",0.915742010892393,0.644482989257241,-0.467818852798339,-5.83364606095977,-0.149792176792079,"NSUN5","NOP2/Sun RNA methyltransferase family member 5",TRUE
+"213670_x_at",0.918373706340477,0.6534336715945,0.45514472268094,-5.83928567338841,0.18622918454639,"NSUN5P1","NOP2/Sun RNA methyltransferase family member 5 pseudogene 1",TRUE
+"214100_x_at",0.951810226174863,0.778763605626115,-0.284375268801525,-5.90037160714232,-0.11165873774245,"NSUN5P1","NOP2/Sun RNA methyltransferase family member 5 pseudogene 1",TRUE
+"213460_x_at",0.95238233774064,0.782268649393588,-0.279744261929444,-5.90163916899536,-0.109894108380184,"NSUN5P2///NSUN5P1","NOP2/Sun RNA methyltransferase family member 5 pseudogene 2///NOP2/Sun RNA methyltransferase family member 5 pseudogene 1",TRUE
+"213842_x_at",0.986611998306681,0.937548605672754,-0.0792456567825945,-5.93662524842296,-0.0243403598005862,"NSUN5P2///NSUN5P1","NOP2/Sun RNA methyltransferase family member 5 pseudogene 2///NOP2/Sun RNA methyltransferase family member 5 pseudogene 1",TRUE
+"1569354_at",0.695744345349551,0.16552767641191,1.43402756194515,-4.98482423156405,0.731017071123397,"NSUN6","NOP2/Sun RNA methyltransferase family member 6",TRUE
+"230200_at",0.76720608863012,0.26917154198094,1.13337617768706,-5.33267834991167,0.830004706242072,"NSUN6","NOP2/Sun RNA methyltransferase family member 6",TRUE
+"222128_at",0.904204980173804,0.606590479520712,0.522379168512716,-5.80764060745618,0.444152726455886,"NSUN6","NOP2/Sun RNA methyltransferase family member 6",TRUE
+"242239_at",0.939064329350179,0.727360499015103,0.353086756027019,-5.87914295057095,0.148185126416906,"NSUN6","NOP2/Sun RNA methyltransferase family member 6",TRUE
+"220194_at",0.668049477824787,0.134198075819609,1.55465091608783,-4.82641912116104,1.07514750080114,"NSUN7","NOP2/Sun RNA methyltransferase family member 7",TRUE
+"238983_at",0.839209135580029,0.42504580489222,0.81268393308613,-5.62302029208823,0.909746608063092,"NSUN7","NOP2/Sun RNA methyltransferase family member 7",TRUE
+"219214_s_at",0.789927874973432,0.319061893933151,-1.01930036446221,-5.44592437493204,-0.43410665859501,"NT5C","5', 3'-nucleotidase, cytosolic",TRUE
+"1557303_at",0.963082887102955,0.832188164943613,-0.214410258315266,-5.91731710468733,-0.105325645549803,"NT5C","5', 3'-nucleotidase, cytosolic",TRUE
+"224529_s_at",0.758230035295206,0.255211839772066,1.16802537431617,-5.29617794362822,0.38689827675035,"NT5C1A","5'-nucleotidase, cytosolic IA",TRUE
+"243100_at",0.748035583613948,0.239897234505024,1.20769824541145,-5.25320645340023,0.946686230051573,"NT5C1B-RDH14///NT5C1B","NT5C1B-RDH14 readthrough///5'-nucleotidase, cytosolic IB",TRUE
+"1554368_at",0.957430653957785,0.807785799015973,0.246210612427725,-5.91020093193902,0.200384737912935,"NT5C1B-RDH14///NT5C1B","NT5C1B-RDH14 readthrough///5'-nucleotidase, cytosolic IB",TRUE
+"222203_s_at",0.683838837468118,0.152737706438744,-1.48081273575494,-4.92460678417878,-0.536802433920606,"NT5C1B-RDH14///RDH14","NT5C1B-RDH14 readthrough///retinol dehydrogenase 14 (all-trans/9-cis/11-cis)",TRUE
+"209155_s_at",0.867924303277286,0.501181538633722,0.683815195697828,-5.71446203865387,0.448198328111335,"NT5C2","5'-nucleotidase, cytosolic II",TRUE
+"241778_at",0.957620703212172,0.810006120922786,0.243306910864996,-5.91089125601125,0.159147328197728,"NT5C2","5'-nucleotidase, cytosolic II",TRUE
+"223298_s_at",0.905508254070782,0.611803939892616,-0.514780284345511,-5.81143011602719,-0.165102934644382,"NT5C3A","5'-nucleotidase, cytosolic IIIA",TRUE
+"225044_at",0.992451894371035,0.96487325909077,0.0445396104565588,-5.93871730235263,0.0188215681132906,"NT5C3B","5'-nucleotidase, cytosolic IIIB",TRUE
+"223177_at",0.69826535129815,0.169173393397574,1.42122692222313,-5.00102509887695,0.525350213937948,"NT5DC1","5'-nucleotidase domain containing 1",TRUE
+"241962_at",0.712055111306836,0.186179665914198,1.36427372473934,-5.07165186104599,0.688148576732639,"NT5DC1","5'-nucleotidase domain containing 1",TRUE
+"223178_s_at",0.760563533925384,0.259725317639156,1.15667257969334,-5.30824364524126,0.474625453352441,"NT5DC1","5'-nucleotidase domain containing 1",TRUE
+"235830_at",0.863769633081355,0.489475565021399,0.702838979735296,-5.70190499542953,0.631394066677616,"NT5DC1","5'-nucleotidase domain containing 1",TRUE
+"1556895_a_at",0.868397087637799,0.503462622745084,0.680137642976862,-5.71685151459644,0.451387199942697,"NT5DC2","5'-nucleotidase domain containing 2",TRUE
+"1556894_at",0.878281464330375,0.531197920573232,0.636146622796555,-5.74447666238775,0.370289100849861,"NT5DC2","5'-nucleotidase domain containing 2",TRUE
+"218051_s_at",0.934612165247339,0.709766709033729,0.376991166004042,-5.87069700913327,0.368964212422641,"NT5DC2","5'-nucleotidase domain containing 2",TRUE
+"234737_at",0.419258213999957,0.017259989685765,-2.57390628623232,-3.14364194132915,-1.46965361685,"NT5DC3","5'-nucleotidase domain containing 3",TRUE
+"218786_at",0.768852835478002,0.274078135559016,1.1215117672668,-5.34495385669081,0.439631115014681,"NT5DC3","5'-nucleotidase domain containing 3",TRUE
+"1562020_s_at",0.522895379075417,0.0386660451321794,2.19827261799048,-3.82566001103849,1.89445800744208,"NT5DC4","5'-nucleotidase domain containing 4",TRUE
+"1560204_at",0.657015752622694,0.125988949231126,1.59006315648418,-4.77799149341419,1.26935664796264,"NT5DC4","5'-nucleotidase domain containing 4",TRUE
+"1562019_at",0.67842163564685,0.145787725787527,1.50758486952605,-4.8894470145957,1.49446202404387,"NT5DC4","5'-nucleotidase domain containing 4",TRUE
+"1553995_a_at",0.449515601463067,0.0214501363368476,2.47489916520976,-3.32908982401224,3.97951170376678,"NT5E","5'-nucleotidase ecto",TRUE
+"203939_at",0.457032025390949,0.0226005226194511,2.45088080927465,-3.37350260528313,4.06931482079194,"NT5E","5'-nucleotidase ecto",TRUE
+"1553994_at",0.529941484988545,0.0414066762482133,2.16521170475425,-3.88266601527822,3.19145350886941,"NT5E","5'-nucleotidase ecto",TRUE
+"227486_at",0.606900628956089,0.0803479079916904,1.83252484810695,-4.42435512892115,2.25716298039535,"NT5E","5'-nucleotidase ecto",TRUE
+"219708_at",0.933609099853387,0.706186176435955,-0.381883037630207,-5.86890134369397,-0.395565043898542,"NT5M","5',3'-nucleotidase, mitochondrial",TRUE
+"213062_at",0.930827859648584,0.693481775730119,0.399318115641638,-5.86231586888994,0.149757094582302,"NTAN1","N-terminal asparagine amidase",TRUE
+"213061_s_at",0.932018790587499,0.699385151576716,0.391201188836951,-5.86541778118903,0.143923264871056,"NTAN1","N-terminal asparagine amidase",TRUE
+"206706_at",0.77547560202111,0.292543436803618,1.07819986605962,-5.38879232253801,0.657776897841058,"NTF3","neurotrophin 3",TRUE
+"209731_at",0.99381841348329,0.970661126628645,0.0371968874010723,-5.93900959856452,0.012942316840677,"NTHL1","nth like DNA glycosylase 1",TRUE
+"241934_at",0.85334340854827,0.461469986477841,0.749449531922985,-5.66975389846057,0.302379387298006,"NTM","neurotrimin",TRUE
+"223368_s_at",0.756795789115566,0.252265263038522,-1.17551762053746,-5.28815870242763,-0.455041449795651,"NTMT1","N-terminal Xaa-Pro-Lys N-methyltransferase 1",TRUE
+"223369_at",0.787929163003677,0.313889671456339,-1.03050891592399,-5.4352747385162,-0.420994214905358,"NTMT1","N-terminal Xaa-Pro-Lys N-methyltransferase 1",TRUE
+"224106_at",0.955816406528307,0.798690042499026,-0.258128812141044,-5.90728223641557,-0.100647282884448,"NTMT1","N-terminal Xaa-Pro-Lys N-methyltransferase 1",TRUE
+"237847_at",0.931209631927021,0.695252096660136,0.396881146628003,-5.86325375615952,0.290835292193016,"NTN1","netrin 1",TRUE
+"227816_at",0.956734254923335,0.803811016382455,-0.251414196408641,-5.90894346806079,-0.163002320447363,"NTN1","netrin 1",TRUE
+"208005_at",0.994174089523038,0.97347715479404,0.0336251434622941,-5.93913279769261,0.0120869739165101,"NTN1","netrin 1",TRUE
+"207640_x_at",0.560295667354693,0.0542507121214805,2.03257819447576,-4.1058254587188,1.45372695275964,"NTN3","netrin 3",TRUE
+"223315_at",0.65426341917745,0.123301879674521,1.60207137174623,-4.76137647287889,2.80449197709111,"NTN4","netrin 4",TRUE
+"1553890_s_at",0.666194265275709,0.133092637578538,1.55931310778145,-4.82009237764886,0.605275848416932,"NTN5","netrin 5",TRUE
+"1558247_s_at",0.797076936586489,0.33023112514965,0.995521801501447,-5.46816797641392,0.384243623961593,"NTN5","netrin 5",TRUE
+"206713_at",0.620912785033482,0.0909468829482789,1.76731903615199,-4.52311463615274,0.810500850138868,"NTNG1","netrin G1",TRUE
+"236088_at",0.819807973515613,0.37782873640737,0.899941785070383,-5.55272928570223,0.575892379230091,"NTNG1","netrin G1",TRUE
+"233966_at",0.986697480734818,0.937871292904628,0.0788353034848915,-5.93665683423097,0.054731709782792,"NTNG1","netrin G1",TRUE
+"233072_at",0.978257169730337,0.895145420590759,0.133317908185671,-5.93103029008999,0.0769378625965205,"NTNG2","netrin G2",TRUE
+"223272_s_at",0.728866069067726,0.210388007353029,-1.28989637341101,-5.16023977509693,-0.786576612408407,"NTPCR","nucleoside-triphosphatase, cancer-related",TRUE
+"226813_at",0.783904511800646,0.306931840565479,-1.04579385679596,-5.42058282443817,-0.505265912545129,"NTPCR","nucleoside-triphosphatase, cancer-related",TRUE
+"229919_at",0.963833408926418,0.834722921738908,0.21112054357146,-5.91799744742123,0.0642383617626043,"NTPCR","nucleoside-triphosphatase, cancer-related",TRUE
+"208605_s_at",0.861962516141708,0.484453749773351,0.711080095892468,-5.69636329658247,0.4505658283793,"NTRK1","neurotrophic receptor tyrosine kinase 1",TRUE
+"221795_at",0.592488489935347,0.0694954070086781,1.90754437626948,-4.30758251541084,1.53092992003904,"NTRK2","neurotrophic receptor tyrosine kinase 2",TRUE
+"221796_at",0.620129049200068,0.0898634194204324,1.7736744742243,-4.51360345393338,1.92372784455799,"NTRK2","neurotrophic receptor tyrosine kinase 2",TRUE
+"236095_at",0.832605695407954,0.409160478132135,0.841314290721809,-5.60069329249321,0.507695560687529,"NTRK2","neurotrophic receptor tyrosine kinase 2",TRUE
+"207152_at",0.912722788750542,0.634340251481149,0.482275674862742,-5.8270281265881,0.132155439411629,"NTRK2","neurotrophic receptor tyrosine kinase 2",TRUE
+"229463_at",0.931582451098271,0.697733686850209,-0.393469175327322,-5.86455737934925,-0.259720502855717,"NTRK2","neurotrophic receptor tyrosine kinase 2",TRUE
+"214680_at",0.93854300027374,0.72657905025307,0.354143957272674,-5.87878096316863,0.202777708366854,"NTRK2","neurotrophic receptor tyrosine kinase 2",TRUE
+"228849_at",0.615821255316333,0.0862966306624256,1.79507340988192,-4.48139580825065,0.837676127235407,"NTRK3","neurotrophic receptor tyrosine kinase 3",TRUE
+"1557795_s_at",0.708193186381687,0.180042436726313,1.38433084748652,-5.04705217037415,0.743635783269037,"NTRK3","neurotrophic receptor tyrosine kinase 3",TRUE
+"215025_at",0.725181883744124,0.203767039445049,-1.30954534175647,-5.13724390779976,-1.03911239261126,"NTRK3","neurotrophic receptor tyrosine kinase 3",TRUE
+"215311_at",0.840041055449124,0.42897932645887,-0.805698553464356,-5.62835777609079,-0.536325756112616,"NTRK3","neurotrophic receptor tyrosine kinase 3",TRUE
+"215115_x_at",0.860085676417428,0.479390171138422,-0.719440018055771,-5.6906788708102,-0.229582928340309,"NTRK3","neurotrophic receptor tyrosine kinase 3",TRUE
+"213960_at",0.882185224252633,0.539717041705094,0.622888016928206,-5.75245465171246,0.313197433371471,"NTRK3","neurotrophic receptor tyrosine kinase 3",TRUE
+"217377_x_at",0.928295253101366,0.685228167500963,-0.410712612103907,-5.85785561700963,-0.14786182829515,"NTRK3","neurotrophic receptor tyrosine kinase 3",TRUE
+"217033_x_at",0.971525376569422,0.864421765211128,-0.172742926560386,-5.92515990162177,-0.0624210028314423,"NTRK3","neurotrophic receptor tyrosine kinase 3",TRUE
+"206462_s_at",0.97689149311934,0.88996796641566,-0.139944809320906,-5.93014906818735,-0.0913418798371533,"NTRK3","neurotrophic receptor tyrosine kinase 3",TRUE
+"231469_at",0.697699759202153,0.168454617667932,1.42373300451016,-4.99786269927712,0.957170298833014,"NTRK3-AS1","NTRK3 antisense RNA 1",TRUE
+"206291_at",0.895702554416613,0.576367046739542,-0.567070296573493,-5.78426133071261,-0.668571654446559,"NTS","neurotensin",TRUE
+"207360_s_at",0.973071267819624,0.869868060568266,0.165735531267389,-5.9263135500117,0.107523152569766,"NTSR1","neurotensin receptor 1 (high affinity)",TRUE
+"206899_at",0.623792624906269,0.0953899564581014,1.74191790084912,-4.56087736725284,0.518373613137807,"NTSR2","neurotensin receptor 2",TRUE
+"204589_at",0.627092759817312,0.098060819338374,1.72713203833503,-4.58267238222442,1.61651485583334,"NUAK1","NUAK family kinase 1",TRUE
+"220987_s_at",0.897949253801113,0.58634079749666,0.552197255383575,-5.79224872503865,0.30263519886331,"NUAK2///AKIP1","NUAK family kinase 2///A-kinase interacting protein 1",TRUE
+"1559732_at",0.568712535922583,0.0586343404663119,1.99372716286499,-4.16944234286507,0.924827053793614,"NUB1","negative regulator of ubiquitin like proteins 1",TRUE
+"1557071_s_at",0.766021622118981,0.266396737287418,1.14015614228502,-5.32561227560301,1.00604613274384,"NUB1","negative regulator of ubiquitin like proteins 1",TRUE
+"1569030_s_at",0.784918343662568,0.309761007795285,-1.0395495486442,-5.4266083994016,-0.575542497919956,"NUB1","negative regulator of ubiquitin like proteins 1",TRUE
+"234332_at",0.82064687791745,0.381382056549561,-0.89313755670563,-5.5584495815332,-0.693384235510757,"NUB1","negative regulator of ubiquitin like proteins 1",TRUE
+"222512_at",0.854810562588402,0.466799997756648,-0.740452878935953,-5.67611220793368,-0.303712630764521,"NUB1","negative regulator of ubiquitin like proteins 1",TRUE
+"203978_at",0.64030781048631,0.110974975988446,-1.66013758224718,-4.67967481182031,-0.545353982731443,"NUBP1","nucleotide binding protein 1",TRUE
+"218227_at",0.322131160460075,0.00719646731150747,-2.96012790647673,-2.3883814676011,-0.863323983011123,"NUBP2","nucleotide binding protein 2",TRUE
+"220176_at",0.839466826665106,0.425477884423972,-0.811914656145234,-5.62361021028374,-0.275232643873004,"NUBPL","nucleotide binding protein like",TRUE
+"200649_at",0.865464356284095,0.49528146765017,0.693371522390292,-5.70819529837131,0.462877129023273,"NUCB1","nucleobindin 1",TRUE
+"200646_s_at",0.937101708029986,0.719258768678159,0.36406756350207,-5.87533099893608,0.205394305977633,"NUCB1","nucleobindin 1",TRUE
+"203675_at",0.782013893500464,0.303630815531069,-1.05313133912533,-5.41346091718258,-0.577067808955382,"NUCB2","nucleobindin 2",TRUE
+"229838_at",0.816199380744005,0.367230637973928,-0.920490361689015,-5.53521088005438,-0.48875922847351,"NUCB2","nucleobindin 2",TRUE
+"224581_s_at",0.456898036702485,0.0223718049925521,-2.45556420220931,-3.36486063108729,-0.678164158226991,"NUCKS1","nuclear casein kinase and cyclin dependent kinase substrate 1",TRUE
+"224582_s_at",0.642592458809121,0.112837539725559,-1.65102693645368,-4.69264143715789,-0.583005079947357,"NUCKS1","nuclear casein kinase and cyclin dependent kinase substrate 1",TRUE
+"226880_at",0.771011793494937,0.279882783113317,-1.10767438899791,-5.35912617418633,-0.345211730628163,"NUCKS1","nuclear casein kinase and cyclin dependent kinase substrate 1",TRUE
+"217802_s_at",0.77796164470392,0.297068057625313,-1.06788912270162,-5.39900147528178,-0.282420274484011,"NUCKS1","nuclear casein kinase and cyclin dependent kinase substrate 1",TRUE
+"222027_at",0.861962516141708,0.48428263122441,0.711361780388655,-5.69617279162623,0.257674680149131,"NUCKS1","nuclear casein kinase and cyclin dependent kinase substrate 1",TRUE
+"229353_s_at",0.88113080359582,0.537468507027298,-0.626376485295614,-5.75037124497483,-0.234929690128988,"NUCKS1","nuclear casein kinase and cyclin dependent kinase substrate 1",TRUE
+"223661_at",0.906476756086155,0.613742636429451,-0.511962371122192,-5.81282163222146,-0.271597983111626,"NUCKS1","nuclear casein kinase and cyclin dependent kinase substrate 1",TRUE
+"222424_s_at",0.93150597990479,0.697137318158125,0.394288695165436,-5.8642452744249,0.186530708540124,"NUCKS1","nuclear casein kinase and cyclin dependent kinase substrate 1",TRUE
+"210574_s_at",0.827866702343255,0.39731851729515,0.863119803145864,-5.58320465187753,0.252701198824337,"NUDC","nuclear distribution C, dynein complex regulator",TRUE
+"201173_x_at",0.919959462096257,0.659359146124654,0.44679585797994,-5.84291771957796,0.158575354429408,"NUDC","nuclear distribution C, dynein complex regulator",TRUE
+"210575_at",0.934612165247339,0.709765003875233,0.376993493424217,-5.87069616023336,0.231024599536501,"NUDC","nuclear distribution C, dynein complex regulator",TRUE
+"225438_at",0.917102138198416,0.649204593421898,-0.461123520723976,-5.8366441919529,-0.223258842761173,"NUDCD1","NudC domain containing 1",TRUE
+"225439_at",0.929614487334131,0.689844510189441,0.404332814402988,-5.86036813734161,0.167338077897195,"NUDCD1","NudC domain containing 1",TRUE
+"226643_s_at",0.758189649141895,0.255153832130633,1.16817224771072,-5.29602117061205,0.324762729470353,"NUDCD2","NudC domain containing 2",TRUE
+"226642_s_at",0.9450937146295,0.752514124786111,0.31926772086103,-5.89015780616375,0.110858642925201,"NUDCD2","NudC domain containing 2",TRUE
+"1558124_at",0.955904644595647,0.800319924783842,-0.255990411209653,-5.90781600981433,-0.162106220356503,"NUDCD2","NudC domain containing 2",TRUE
+"201270_x_at",0.816800680706682,0.368579245817297,-0.917853897960569,-5.53747895687468,-0.299052396537293,"NUDCD3","NudC domain containing 3",TRUE
+"201269_s_at",0.837345289209351,0.420210466648864,-0.821326359762738,-5.61635687451306,-0.347271017896937,"NUDCD3","NudC domain containing 3",TRUE
+"242238_at",0.903919439852106,0.605774042969771,-0.523571980434377,-5.80704084890555,-0.331233865004216,"NUDCD3","NudC domain containing 3",TRUE
+"204766_s_at",0.975398143273847,0.881733185554118,0.15049830904727,-5.92865764458502,0.0687118664404558,"NUDT1","nudix hydrolase 1",TRUE
+"241598_at",0.897011777275924,0.582607710754014,0.55774919104568,-5.78929121539103,0.206331839002293,"NUDT10","nudix hydrolase 10",TRUE
+"241596_at",0.99925604280637,0.997574624316417,0.00307424336622377,-5.93967887753001,0.00209819176058446,"NUDT10","nudix hydrolase 10",TRUE
+"219855_at",0.873425145273859,0.518719485911065,0.655777494064834,-5.73236784222759,0.649379641642452,"NUDT11","nudix hydrolase 11",TRUE
+"223535_at",0.614178202960275,0.0851050007650601,-1.80239271140983,-4.47031503348558,-0.743497313972607,"NUDT12","nudix hydrolase 12",TRUE
+"1562775_at",0.984360502484283,0.923801970939854,0.0967408017284054,-5.93512619054365,0.072469442485783,"NUDT12","nudix hydrolase 12",TRUE
+"207917_at",0.725276957219979,0.204152032402661,1.30838933540497,-5.13860497524399,0.537872919154893,"NUDT13","nudix hydrolase 13",TRUE
+"214136_at",0.774230543658252,0.287826978167362,1.08907034919312,-5.37793411412833,0.573420969182268,"NUDT13","nudix hydrolase 13",TRUE
+"231910_at",0.920714895152417,0.662669367414654,0.442145871787687,-5.84491202657546,0.251366762982506,"NUDT14","nudix hydrolase 14",TRUE
+"231914_at",0.994145854504594,0.973276244987116,0.0338799544715769,-5.9391244201592,0.0252836599754769,"NUDT14","nudix hydrolase 14",TRUE
+"219347_at",0.567651250567208,0.0577355516551508,2.00147737256732,-4.15681716607488,0.863488119327455,"NUDT15","nudix hydrolase 15",TRUE
+"228341_at",0.585036027492332,0.0655865481402805,-1.93709714115234,-4.26068458264244,-0.675113900256483,"NUDT16","nudix hydrolase 16",TRUE
+"238515_at",0.778580821633075,0.298873745796936,-1.06380565778775,-5.40302043466022,-0.382630567956102,"NUDT16","nudix hydrolase 16",TRUE
+"235054_at",0.835952408568777,0.416515451907486,-0.827972796765698,-5.61118748071874,-0.259597173071406,"NUDT16","nudix hydrolase 16",TRUE
+"235002_at",0.91050558382084,0.627601669199931,0.491938200148138,-5.82249510460448,0.245632343789342,"NUDT16","nudix hydrolase 16",TRUE
+"224477_s_at",0.610404195568275,0.0828274115577692,-1.81663220540037,-4.44866426423429,-0.674400628027396,"NUDT16L1","nudix hydrolase 16 like 1",TRUE
+"232251_at",0.611042853196665,0.083413498705098,1.81293592704269,-4.45429618065473,1.16008467433452,"NUDT16P1","nudix hydrolase 16 pseudogene 1",TRUE
+"1568593_a_at",0.986145735582101,0.932321443286647,-0.0858949026128413,-5.93609059977755,-0.0964227206225985,"NUDT16P1","nudix hydrolase 16 pseudogene 1",TRUE
+"1561847_at",0.96635324070119,0.843256349219105,0.200062770285481,-5.92020750606124,0.0714598769801063,"NUDT17","nudix hydrolase 17",TRUE
+"229044_at",0.990810941805126,0.954551899101998,0.0576402051659584,-5.93806539504556,0.0164403665604027,"NUDT17","nudix hydrolase 17",TRUE
+"219665_at",0.929274066532249,0.689115995016919,-0.405338483556255,-5.85997465040815,-0.170764588776266,"NUDT18","nudix hydrolase 18",TRUE
+"235384_at",0.995710500788917,0.979465896002384,-0.0260306806688833,-5.93935345394562,-0.0281783299113858,"NUDT19","nudix hydrolase 19",TRUE
+"218609_s_at",0.866602763987519,0.497735075690487,0.689389599778842,-5.71081661399123,0.309066271367858,"NUDT2","nudix hydrolase 2",TRUE
+"213461_at",0.92777930247318,0.683194796941361,-0.413528229961984,-5.85673444938937,-0.124315823007903,"NUDT21","nudix hydrolase 21",TRUE
+"224830_at",0.955904644595647,0.800608548858485,0.255611864628528,-5.9079100404215,0.062383137707906,"NUDT21","nudix hydrolase 21",TRUE
+"202697_at",0.992031007642741,0.963121192891416,-0.0467628285055512,-5.9386184456669,-0.0154085975716551,"NUDT21","nudix hydrolase 21",TRUE
+"224464_s_at",0.921294973929502,0.664293896098612,-0.4398674625631,-5.84588172725914,-0.167402393566348,"NUDT22","nudix hydrolase 22",TRUE
+"223372_at",0.936143408699214,0.714783061863193,-0.370153309821975,-5.87316871568146,-0.354036346866116,"NUDT22","nudix hydrolase 22",TRUE
+"1569990_at",0.690381347688918,0.160094752963009,1.45353083643504,-4.95991237518782,0.545975797693892,"NUDT3","nudix hydrolase 3",TRUE
+"212605_s_at",0.844608293507187,0.441498034356386,0.783727595134877,-5.64486316703061,0.275093221329412,"NUDT3","nudix hydrolase 3",TRUE
+"212608_s_at",0.853873348661023,0.462739228547345,0.747301558985127,-5.67127857271033,0.286297053226015,"NUDT3","nudix hydrolase 3",TRUE
+"211973_at",0.888312537451395,0.554325121717046,0.600410271088814,-5.76560987250404,0.16713221943518,"NUDT3","nudix hydrolase 3",TRUE
+"211976_at",0.986844665519238,0.938469771809226,0.0780742694631126,-5.93671497890482,0.0225312347272268,"NUDT3","nudix hydrolase 3",TRUE
+"229836_s_at",0.843950128127185,0.440131707553089,-0.786106767086092,-5.64309658410426,-0.520134420219633,"NUDT4","nudix hydrolase 4",TRUE
+"227683_x_at",0.851319596585235,0.455227620767762,-0.760065442616795,-5.66215769275527,-0.322507153328589,"NUDT4","nudix hydrolase 4",TRUE
+"212182_at",0.9181984176728,0.652784274355959,-0.456061699106104,-5.83888273917165,-0.462461968935417,"NUDT4","nudix hydrolase 4",TRUE
+"212183_at",0.635916735157933,0.107065878477448,-1.67968639624818,-4.65166910817943,-1.05426476395375,"NUDT4P1///NUDT4","nudix hydrolase 4 pseudogene 1///nudix hydrolase 4",TRUE
+"212181_s_at",0.65086850539757,0.120727217469514,-1.61378385049355,-4.7450771774378,-0.90637802909132,"NUDT4P1///NUDT4P2///NUDT4","nudix hydrolase 4 pseudogene 1///nudix hydrolase 4 pseudogene 2///nudix hydrolase 4",TRUE
+"206303_s_at",0.728385463227073,0.209433410659752,-1.29269947769648,-5.1569772497415,-0.606473920422752,"NUDT4P1///NUDT4P2///NUDT4","nudix hydrolase 4 pseudogene 1///nudix hydrolase 4 pseudogene 2///nudix hydrolase 4",TRUE
+"206302_s_at",0.822173415758858,0.386253440254962,-0.883876600590358,-5.56617064224268,-0.490299401470232,"NUDT4P1///NUDT4P2///NUDT4","nudix hydrolase 4 pseudogene 1///nudix hydrolase 4 pseudogene 2///nudix hydrolase 4",TRUE
+"223100_s_at",0.832792886465252,0.409710192078277,0.840311908793537,-5.6014871942833,0.255121859527373,"NUDT5","nudix hydrolase 5",TRUE
+"222824_at",0.980001024522674,0.904801582980962,-0.120974547103354,-5.93255790217206,-0.0501399845282151,"NUDT5","nudix hydrolase 5",TRUE
+"220183_s_at",0.615821255316333,0.0867475289403043,-1.79232661228214,-4.48554576541977,-1.56763217380438,"NUDT6","nudix hydrolase 6",TRUE
+"230329_s_at",0.840534412910497,0.429683344139888,-0.804452527577887,-5.62930530978728,-0.368107376390039,"NUDT6","nudix hydrolase 6",TRUE
+"228855_at",0.642592458809121,0.11248955216282,-1.65271942566475,-4.69023674101766,-1.68237958817381,"NUDT7","nudix hydrolase 7",TRUE
+"215818_at",0.775484207208998,0.292747947632258,-1.0777313681102,-5.38925810577613,-0.674124282693349,"NUDT7","nudix hydrolase 7",TRUE
+"218375_at",0.694650603490298,0.164149717367986,-1.43892481208382,-4.97859470770199,-0.575210015291523,"NUDT9","nudix hydrolase 9",TRUE
+"1552564_at",0.970274748961658,0.85871843429313,0.180090541211234,-5.92389909039926,0.139820330957308,"NUDT9P1","nudix hydrolase 9 pseudogene 1",TRUE
+"223381_at",0.965992617204023,0.8410952853217,-0.202860649224844,-5.9196594969388,-0.0674104482590803,"NUF2","NUF2, NDC80 kinetochore complex component",TRUE
+"205134_s_at",0.75235436509186,0.245708698386507,1.1924261919501,-5.26989632521888,0.426488180209789,"NUFIP1","NUFIP1, FMR1 interacting protein 1",TRUE
+"205135_s_at",0.896118635245982,0.577947236785273,0.564705341117446,-5.78554516933867,0.215503342942908,"NUFIP1","NUFIP1, FMR1 interacting protein 1",TRUE
+"205136_s_at",0.935094665155941,0.711505852420836,0.374618460011288,-5.87155973737564,0.149763961109674,"NUFIP1","NUFIP1, FMR1 interacting protein 1",TRUE
+"224958_at",0.833184482935234,0.410504847168677,-0.838864395963319,-5.60263208659173,-0.271278320035032,"NUFIP2","NUFIP2, FMR1 interacting protein 2",TRUE
+"224956_at",0.844784569834367,0.441713786601278,-0.783352320215185,-5.64514135551388,-0.217374579306364,"NUFIP2","NUFIP2, FMR1 interacting protein 2",TRUE
+"224938_at",0.856257656023992,0.469980765669011,0.735113008705219,-5.67985167623973,0.261073635307744,"NUFIP2","NUFIP2, FMR1 interacting protein 2",TRUE
+"224939_at",0.987967825391489,0.942522208914862,0.0729223540158835,-5.9370937717597,0.0224138229847437,"NUFIP2","NUFIP2, FMR1 interacting protein 2",TRUE
+"235539_at",0.774230543658252,0.287050712840094,1.09087175209917,-5.3761253661291,0.553154465099603,"NUMA1","nuclear mitotic apparatus protein 1",TRUE
+"200747_s_at",0.78226567430527,0.30439493245465,-1.05142785488175,-5.41511834029899,-0.382193648159911,"NUMA1","nuclear mitotic apparatus protein 1",TRUE
+"1554663_a_at",0.803380396640681,0.341394424061263,0.972305601425354,-5.48942492981432,1.1242405572248,"NUMA1","nuclear mitotic apparatus protein 1",TRUE
+"214251_s_at",0.895690630367785,0.57539369769426,-0.56852866423529,-5.7834670492892,-0.219175432342483,"NUMA1","nuclear mitotic apparatus protein 1",TRUE
+"214250_at",0.968066640321622,0.849698343640902,0.191732063022703,-5.92179430835748,0.230312311818198,"NUMA1","nuclear mitotic apparatus protein 1",TRUE
+"230462_at",0.955892698633978,0.799475600242041,-0.257098009693539,-5.90754008925726,-0.125821992940445,"NUMB","NUMB, endocytic adaptor protein",TRUE
+"224059_s_at",0.7994347047598,0.334499968665771,-0.986581058649202,-5.47640824697314,-0.506171335069439,"NUMBL","NUMB like, endocytic adaptor protein",TRUE
+"242195_x_at",0.839781238235762,0.428604118780861,-0.806363144634499,-5.627851828133,-0.265295131968507,"NUMBL","NUMB like, endocytic adaptor protein",TRUE
+"218768_at",0.861357981297227,0.481662759019142,0.715681677439881,-5.69324222137507,0.17015623623425,"NUP107","nucleoporin 107",TRUE
+"202184_s_at",0.822194239143673,0.386806505728796,-0.882830006460335,-5.56703851966227,-0.248685993031867,"NUP133","nucleoporin 133",TRUE
+"233421_s_at",0.910276798053706,0.627109126089102,-0.492646317595342,-5.8221594470644,-0.186996077379066,"NUP133","nucleoporin 133",TRUE
+"1559064_at",0.446963972064621,0.0211036257978018,2.48236868194033,-3.31523091999126,1.32403523180559,"NUP153","nucleoporin 153",TRUE
+"202097_at",0.721499527275875,0.197747724645352,1.32784450908467,-5.11556356485349,0.414428310055438,"NUP153","nucleoporin 153",TRUE
+"239948_at",0.747587302711183,0.239494732261292,1.20876625097725,-5.25203239762203,0.780126612318156,"NUP153","nucleoporin 153",TRUE
+"206550_s_at",0.240221409886232,0.0031950647807349,3.30592535448651,-1.67882066330464,1.05535031898116,"NUP155","nucleoporin 155",TRUE
+"214963_at",0.937856707467078,0.725107991761606,0.356135230882347,-5.87809624445581,0.179404383696041,"NUP160","nucleoporin 160",TRUE
+"212709_at",0.969891556938326,0.857484504464564,-0.181681537681498,-5.92361918900012,-0.063916153393544,"NUP160","nucleoporin 160",TRUE
+"214962_s_at",0.996625121774816,0.983150530399524,-0.0213589183251109,-5.9394612833397,-0.00959999276554058,"NUP160","nucleoporin 160",TRUE
+"212691_at",0.859947009633611,0.478412800038224,-0.721059560280709,-5.68957033580602,-0.249478093928735,"NUP188","nucleoporin 188",TRUE
+"214675_at",0.886837210100958,0.550408114652832,0.606406437791663,-5.76214620048059,0.28151271795736,"NUP188","nucleoporin 188",TRUE
+"217601_at",0.965584868976477,0.839019359532545,0.205549862467789,-5.91912562725853,0.125399077429391,"NUP188","nucleoporin 188",TRUE
+"222382_x_at",0.584828007864693,0.0650754578256208,-1.9410750801425,-4.25433395484573,-0.802428838550782,"NUP205","nucleoporin 205",TRUE
+"212247_at",0.964181293782946,0.83557088362183,-0.210020556302689,-5.91822259809782,-0.0710170977965561,"NUP205","nucleoporin 205",TRUE
+"213945_s_at",0.722937902375896,0.199649516352085,1.3220165126338,-5.12249595278367,0.661188146583307,"NUP210","nucleoporin 210",TRUE
+"220035_at",0.774230543658252,0.289946816497251,-1.08416881785368,-5.38284214023948,-0.670178565323702,"NUP210","nucleoporin 210",TRUE
+"212315_s_at",0.992342196993659,0.964135430758711,0.0454758210706559,-5.93867625989312,0.036311759362663,"NUP210","nucleoporin 210",TRUE
+"213947_s_at",0.996261754016157,0.98149862322371,-0.0234533112751719,-5.93941557142171,-0.0175685824060707,"NUP210","nucleoporin 210",TRUE
+"212316_at",0.998347572104896,0.993050324008091,0.00880904722381354,-5.93964568505547,0.00552503234833068,"NUP210","nucleoporin 210",TRUE
+"232598_at",0.971216837324271,0.863082236973552,-0.174467754286625,-5.92486863309408,-0.230910159280012,"NUP210L","nucleoporin 210 like",TRUE
+"244681_at",0.787211643646529,0.313028098473307,-1.03238857732937,-5.43347851630392,-0.692914861115998,"NUP210P1","nucleoporin 210 pseudogene 1",TRUE
+"228902_at",0.819018525257656,0.373722863796905,0.907856788430212,-5.5460246836537,0.333155225720162,"NUP214","nucleoporin 214",TRUE
+"211261_at",0.888830748858811,0.556083098752278,-0.59772636790634,-5.76714945399484,-0.172088743869796,"NUP214","nucleoporin 214",TRUE
+"202155_s_at",0.957571530817866,0.809256953567505,0.244286419706551,-5.91065929832561,0.0702179880380136,"NUP214","nucleoporin 214",TRUE
+"225470_at",0.886958786025922,0.550814789588005,0.605782858398814,-5.76250795765678,0.193604801055777,"NUP35","nucleoporin 35",TRUE
+"218622_at",0.963545554770237,0.833980179028659,0.212084258054057,-5.91779922725191,0.0608417664251242,"NUP37","nucleoporin 37",TRUE
+"238637_at",0.987512421689914,0.941240644207125,0.0745513983045752,-5.9369767897538,0.0225191925133146,"NUP37","nucleoporin 37",TRUE
+"238474_at",0.794620886196317,0.326666288372369,1.00304951900177,-5.46117768145449,0.397312940766328,"NUP43","nucleoporin 43",TRUE
+"219007_at",0.870808709484996,0.510123040118403,0.669453152510116,-5.72372377906093,0.211811058223869,"NUP43","nucleoporin 43",TRUE
+"218295_s_at",0.588653540532996,0.0673775301536273,1.92336956307612,-4.28253119161876,0.793143271492143,"NUP50","nucleoporin 50",TRUE
+"222583_s_at",0.615821255316333,0.0868539439037667,1.79168014686611,-4.4865217960612,0.721373386284762,"NUP50","nucleoporin 50",TRUE
+"218293_x_at",0.625205501341047,0.0964308732109566,1.73611382255315,-4.56944928061556,1.3685239824593,"NUP50","nucleoporin 50",TRUE
+"218294_s_at",0.832605695407954,0.409243297759651,0.841163217599971,-5.6008130012754,0.309402355356077,"NUP50","nucleoporin 50",TRUE
+"231064_s_at",0.900736310608905,0.596194898152132,0.53762530095497,-5.79987444971343,0.166724468727192,"NUP50","nucleoporin 50",TRUE
+"213682_at",0.952697366942815,0.783712290315263,0.277838685688718,-5.90215474980812,0.0989110908542585,"NUP50","nucleoporin 50",TRUE
+"240233_at",0.760317850062887,0.258918299960144,1.15869168504675,-5.30610530615307,0.777426277997844,"NUP50-AS1","NUP50 antisense RNA 1 (head to head)",TRUE
+"215213_at",0.796908793766655,0.329753352540957,0.996527416575266,-5.46723692141656,0.82845670629041,"NUP54","nucleoporin 54",TRUE
+"231301_at",0.937113154905832,0.720417699585467,-0.36249402199313,-5.8758843248999,-0.348657573061959,"NUP54","nucleoporin 54",TRUE
+"218256_s_at",0.979588787486838,0.90190285899603,-0.124677841682669,-5.93211513160748,-0.0369950067302582,"NUP54","nucleoporin 54",TRUE
+"204435_at",0.75710709622615,0.252975822896562,-1.17370494883252,-5.29010298806346,-0.49464167272715,"NUP58","nucleoporin 58",TRUE
+"225047_at",0.801836064296888,0.339285713905736,-0.976650666384775,-5.48548130652919,-0.358828186729234,"NUP58","nucleoporin 58",TRUE
+"241425_at",0.837609393049242,0.421927884235985,0.818249640731413,-5.61873663655419,0.572390538428679,"NUP58","nucleoporin 58",TRUE
+"223984_s_at",0.953983577550391,0.787860844806987,-0.272368495697556,-5.90361535245396,-0.125700319099742,"NUP58","nucleoporin 58",TRUE
+"207740_s_at",0.812302873476553,0.35894545561482,0.936831036338288,-5.52101995498312,0.340751590832626,"NUP62","nucleoporin 62",TRUE
+"236505_at",0.906476756086155,0.613860269304954,0.511791525932036,-5.81290575800597,0.269465043093119,"NUP62","nucleoporin 62",TRUE
+"202153_s_at",0.923823689093359,0.672722750024014,0.428083520704217,-5.8508185060552,0.140485157703386,"NUP62","nucleoporin 62",TRUE
+"220520_s_at",0.673322773608689,0.139073325694795,1.53446015880005,-4.85364572499394,2.66729103845338,"NUP62CL","nucleoporin 62 C-terminal like",TRUE
+"232960_at",0.863243647327548,0.487410967291243,0.70622117873554,-5.6996380994019,0.535133685506645,"NUP62CL","nucleoporin 62 C-terminal like",TRUE
+"218014_at",0.950358151876194,0.774458410065338,0.290072184473549,-5.8987839697621,0.118746085174198,"NUP85","nucleoporin 85",TRUE
+"202900_s_at",0.744931128252932,0.236657501124862,1.21633325997376,-5.24368824301855,0.520077105194776,"NUP88","nucleoporin 88",TRUE
+"214192_at",0.969946179106301,0.857757128471418,0.181329982341667,-5.92368124878017,0.0598900137593286,"NUP88","nucleoporin 88",TRUE
+"241758_at",0.968303740374882,0.851186362503842,-0.189809769648065,-5.92215091205584,-0.150776968323566,"NUP93","nucleoporin 93",TRUE
+"202188_at",0.974982245454858,0.877923584440027,0.155386456218262,-5.92793020345659,0.0627860935120861,"NUP93","nucleoporin 93",TRUE
+"210793_s_at",0.62952950109137,0.10037108752526,-1.71461717814418,-4.60101166821778,-0.652621411583572,"NUP98","nucleoporin 98",TRUE
+"203195_s_at",0.869971289491322,0.508050697248037,0.672769119676684,-5.72160209379422,0.282145001940918,"NUP98","nucleoporin 98",TRUE
+"203194_s_at",0.951023815565189,0.77645637134,-0.287427144384417,-5.89952498435023,-0.0994017137927727,"NUP98","nucleoporin 98",TRUE
+"204003_s_at",0.454579023204608,0.0220200862900515,2.46285374240955,-3.35139212609835,0.895871291658841,"NUPL2","nucleoporin like 2",TRUE
+"209230_s_at",0.782446789676962,0.304592546346309,-1.05098779835333,-5.41554610630421,-1.25349636820226,"NUPR1","nuclear protein 1, transcriptional regulator",TRUE
+"225071_at",0.739189560382301,0.226272013648701,1.24463177597013,-5.21208499830418,0.597754032897505,"NUS1","NUS1 dehydrodolichyl diphosphate synthase subunit",TRUE
+"225070_at",0.81250312871878,0.361082780459239,0.93259167470719,-5.52472364984767,0.399402563683827,"NUS1","NUS1 dehydrodolichyl diphosphate synthase subunit",TRUE
+"215207_x_at",0.593339168375633,0.0701670210462036,1.9026143219182,-4.31535740985953,0.724953314012508,"NUS1///NUS1P3","NUS1 dehydrodolichyl diphosphate synthase subunit///NUS1 dehydrodolichyl diphosphate synthase subunit pseudogene 3",TRUE
+"37079_at",0.665332084581732,0.132698862591042,1.56098159255226,-4.81782456529028,0.698361823859026,"NUS1P3","NUS1 dehydrodolichyl diphosphate synthase subunit pseudogene 3",TRUE
+"219978_s_at",0.9727355927549,0.868006331287566,0.168129924174086,-5.92592471160577,0.0728473056675529,"NUSAP1","nucleolar and spindle associated protein 1",TRUE
+"218039_at",0.985498770484702,0.929990939108197,-0.0888606966063782,-5.93583825315374,-0.0348576502423956,"NUSAP1","nucleolar and spindle associated protein 1",TRUE
+"228379_at",0.886783047600321,0.550217233847242,0.606699210533614,-5.76197623028659,0.193910559691481,"NUTF2P4///NUTF2","nuclear transport factor 2 pseudogene 4///nuclear transport factor 2",TRUE
+"202397_at",0.998038817582822,0.990676315900825,-0.0118183440035991,-5.93961545128526,-0.0048570655535034,"NUTF2P4///NUTF2","nuclear transport factor 2 pseudogene 4///nuclear transport factor 2",TRUE
+"231338_at",0.969882914559333,0.856527814614598,0.182915398422664,-5.92340042832701,0.124113901710037,"NUTM1","NUT midline carcinoma family member 1",TRUE
+"1564603_at",0.993615552413264,0.970072769877238,0.0379431979678603,-5.93898228697465,0.0299978583302414,"NUTM1","NUT midline carcinoma family member 1",TRUE
+"1558794_at",0.896115372949367,0.577283350250438,-0.565698534665514,-5.7850066383433,-0.287892365220308,"NUTM2A-AS1","NUTM2A antisense RNA 1",TRUE
+"234695_x_at",0.836485547029392,0.418204525432985,-0.824929977724675,-5.61355893287101,-0.440068006053626,"NUTM2B","NUT family member 2B",TRUE
+"235730_at",0.839519981963042,0.427786802726926,-0.807812079047239,-5.62674740806089,-0.396433556202743,"NUTM2B-AS1","NUTM2B antisense RNA 1",TRUE
+"229318_at",0.985361089461736,0.92737009010323,0.0921969599097721,-5.93554415595472,0.0587821383200922,"NUTM2B-AS1","NUTM2B antisense RNA 1",TRUE
+"229609_at",0.895690630367785,0.576011742505698,0.567602504319969,-5.78397169967914,0.157182607118663,"NUTM2B-AS1///NUTM2A-AS1","NUTM2B antisense RNA 1///NUTM2A antisense RNA 1",TRUE
+"227724_at",0.925679011537716,0.678624868909353,0.419868701059886,-5.85418211770441,0.283128379607159,"NUTM2B-AS1///NUTM2A-AS1","NUTM2B antisense RNA 1///NUTM2A antisense RNA 1",TRUE
+"235332_at",0.988776423002819,0.946042473527635,0.0684486422536205,-5.93740174209913,0.0305562102482728,"NUTM2B///NUTM2A","NUT family member 2B///NUT family member 2A",TRUE
+"234414_at",0.906476756086155,0.613234553135445,0.512700467998963,-5.8124578717387,0.259405114635982,"NUTM2G///NUTM2F","NUT family member 2G///NUT family member 2F",TRUE
+"207877_s_at",0.804537788156734,0.343421987696673,-0.968145022824515,-5.49318607281418,-0.489242877093849,"NVL","nuclear VCP-like",TRUE
+"230765_at",0.841550580403629,0.433071392330844,0.798473735560459,-5.63383268033457,0.621797335099848,"NWD2","NACHT and WD repeat domain containing 2",TRUE
+"208922_s_at",0.637485146909712,0.108994705879919,-1.6699665723763,-4.66562488662742,-0.429220515344703,"NXF1","nuclear RNA export factor 1",TRUE
+"220981_x_at",0.783215903203604,0.305751444681806,1.04841117309263,-5.41804753887629,0.704911379501945,"NXF2B///NXF2","nuclear RNA export factor 2B///nuclear RNA export factor 2",TRUE
+"234173_s_at",0.872670205591254,0.516831174749939,0.658770668910305,-5.73049054693404,0.484599422393425,"NXF2B///NXF2","nuclear RNA export factor 2B///nuclear RNA export factor 2",TRUE
+"220257_x_at",0.929174162829875,0.688549069615276,-0.406121382553557,-5.85966766045885,-0.185248241208554,"NXF2B///NXF2","nuclear RNA export factor 2B///nuclear RNA export factor 2",TRUE
+"222949_at",0.463552233135475,0.0236641485367648,2.42966306668775,-3.41254283508508,1.36110692720308,"NXF3","nuclear RNA export factor 3",TRUE
+"220110_s_at",0.610486790071853,0.0832066229140136,1.81423805704055,-4.4523131053484,0.761401373195882,"NXF3","nuclear RNA export factor 3",TRUE
+"234648_s_at",0.623503825356688,0.0941220821800552,1.74906114329022,-4.55029860392383,0.941952643590433,"NXF5","nuclear RNA export factor 5",TRUE
+"219489_s_at",0.539609110035715,0.0443542938228144,2.1317941475988,-3.93973897214998,2.57459694629428,"NXN","nucleoredoxin",TRUE
+"1553755_at",0.831875452294783,0.407059527597412,0.845153208571316,-5.59764463964683,0.250806283735076,"NXNL1","nucleoredoxin-like 1",TRUE
+"1552816_at",0.860567464069796,0.480090597935803,0.71828056792262,-5.6914710282971,0.640629796469397,"NXNL2","nucleoredoxin-like 2",TRUE
+"1553828_at",0.890004112942188,0.55825680938916,0.594413873860429,-5.76904042909509,0.200354170337839,"NXPE1","neurexophilin and PC-esterase domain family member 1",TRUE
+"1561387_a_at",0.994536266629158,0.974747851841458,0.0320135888692974,-5.93918431674939,0.023242782647241,"NXPE1","neurexophilin and PC-esterase domain family member 1",TRUE
+"217540_at",0.859064198633089,0.475598962721679,0.725733026702391,-5.68635818241017,0.769141657235477,"NXPE3","neurexophilin and PC-esterase domain family member 3",TRUE
+"235030_at",0.875279162021058,0.522499843576558,0.649803236759386,-5.73609032145352,0.463011568743458,"NXPE3","neurexophilin and PC-esterase domain family member 3",TRUE
+"243606_at",0.955396260969248,0.795740764816865,-0.262001392204196,-5.90630436008895,-0.154388713291393,"NXPE3","neurexophilin and PC-esterase domain family member 3",TRUE
+"243011_at",0.955892698633978,0.799954844821695,0.256469288722821,-5.90769685899752,0.14306370812372,"NXPE3","neurexophilin and PC-esterase domain family member 3",TRUE
+"220645_at",0.603702127972549,0.0776073483927736,1.85059390714442,-4.3965330093699,0.608460633005086,"NXPE4","neurexophilin and PC-esterase domain family member 4",TRUE
+"232377_at",0.979388236370534,0.900812930289927,-0.126070750536193,-5.93194514389725,-0.152616480613934,"NXPH1","neurexophilin 1",TRUE
+"230883_at",0.673366993714442,0.139429788551576,-1.53300687673986,-4.85559454969791,-1.24510354856744,"NXPH2","neurexophilin 2",TRUE
+"1559355_at",0.848475456105025,0.448721331017143,0.77122386061445,-5.65406442992325,0.493895544244035,"NXPH2","neurexophilin 2",TRUE
+"232334_at",0.908709061737317,0.620628111115322,0.501987921313277,-5.81768726482814,0.27066866345555,"NXPH2","neurexophilin 2",TRUE
+"228210_at",0.877740599174557,0.528544616066306,-0.640299495658491,-5.74194455175688,-0.363442950462115,"NXPH3","neurexophilin 3",TRUE
+"221991_at",0.918409982899324,0.653698395178771,0.454771035469364,-5.83944964959117,0.200401747274738,"NXPH3","neurexophilin 3",TRUE
+"221967_at",0.977874971442423,0.893041577851457,-0.136009974725362,-5.93067745410501,-0.0514384036266415,"NXPH4","neurexophilin 4",TRUE
+"218708_at",0.958325326717984,0.8115166372508,-0.241332704746917,-5.91135595211375,-0.0870978506793918,"NXT1","nuclear transport factor 2 like export factor 1",TRUE
+"209629_s_at",0.773107052530371,0.283884246904031,-1.09825650568371,-5.36868268713399,-0.415000123841722,"NXT2","nuclear transport factor 2 like export factor 2",TRUE
+"209628_at",0.912722788750542,0.633934235954147,-0.482856539162991,-5.8267581064828,-0.247256289101442,"NXT2","nuclear transport factor 2 like export factor 2",TRUE
+"1553288_a_at",0.69794616906853,0.16889421694546,1.42219928251334,-4.99979863001279,0.626399334768751,"NYAP1","neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1",TRUE
+"233916_at",0.632949074657601,0.103769845935422,1.69664456342788,-4.62717396275241,1.24857377928059,"NYAP2","neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2",TRUE
+"220911_s_at",0.508488499910913,0.0335122144053183,2.26667207591096,-3.70605827668456,2.48685150903417,"NYNRIN","NYN domain and retroviral integrase containing",TRUE
+"221684_s_at",0.895657764833717,0.575000413829964,-0.569118274278559,-5.78314536433882,-0.425093246549942,"NYX","nyctalopin",TRUE
+"234496_x_at",0.931581710804274,0.69752340332703,0.393758112079883,-5.8644474140467,0.252753537077454,"NYX","nyctalopin",TRUE
+"225510_at",0.697871681043328,0.168829423413994,1.42242513997933,-4.9995136503415,1.3496892415021,"OAF","out at first homolog",TRUE
+"228939_at",0.763502833200335,0.263294108490922,1.14779890639376,-5.31760248425154,0.333566760760137,"OAF","out at first homolog",TRUE
+"213322_at",0.954724542854807,0.79422476642176,0.2639935801866,-5.90579567219139,0.0955548450445907,"OARD1","O-acyl-ADP-ribose deacylase 1",TRUE
+"238860_at",0.957571530817866,0.809579247577735,0.243865002222641,-5.9107592078565,0.0874199032275982,"OARD1","O-acyl-ADP-ribose deacylase 1",TRUE
+"202869_at",0.447294524001345,0.0212087662613999,2.48009024956496,-3.31946065226658,2.40853660394725,"OAS1","2'-5'-oligoadenylate synthetase 1",TRUE
+"205552_s_at",0.540986404840943,0.0451291996795526,2.12334202651698,-3.95408542521759,2.17534447726963,"OAS1","2'-5'-oligoadenylate synthetase 1",TRUE
+"206553_at",0.535243600695458,0.0426241278180716,2.15115679463784,-3.90673783116295,2.47640673482107,"OAS2","2'-5'-oligoadenylate synthetase 2",TRUE
+"204972_at",0.674438494582062,0.140864768040193,1.52718726254714,-4.86338384555772,1.4603106799996,"OAS2","2'-5'-oligoadenylate synthetase 2",TRUE
+"228607_at",0.938604979152649,0.726644198583874,0.354055804126289,-5.87881118780868,0.227775527834604,"OAS2","2'-5'-oligoadenylate synthetase 2",TRUE
+"232666_at",0.607623086758882,0.0810497516549158,1.82798363772723,-4.43131680909977,0.996455567228459,"OAS3","2'-5'-oligoadenylate synthetase 3",TRUE
+"218400_at",0.666643938027574,0.133360230164918,1.5581816058709,-4.821629233638,0.961852056444014,"OAS3","2'-5'-oligoadenylate synthetase 3",TRUE
+"205660_at",0.540483367247649,0.0449137571697617,2.12567871498041,-3.9501227908635,1.34989673770067,"OASL","2'-5'-oligoadenylate synthetase like",TRUE
+"210797_s_at",0.623667408398064,0.0950404052561314,1.74387912841907,-4.55797608329846,1.0850248838282,"OASL","2'-5'-oligoadenylate synthetase like",TRUE
+"201599_at",0.784498961298069,0.307663315481014,1.04417551681709,-5.42214759194533,0.608378463004183,"OAT","ornithine aminotransferase",TRUE
+"215952_s_at",0.854040699678541,0.463349628064169,-0.746269814158959,-5.67200945187602,-0.151134378478504,"OAZ1","ornithine decarboxylase antizyme 1",TRUE
+"200077_s_at",0.931582451098271,0.698052756900864,-0.393030827258164,-5.86472405667464,-0.0763809245600822,"OAZ1","ornithine decarboxylase antizyme 1",TRUE
+"201364_s_at",0.280199223932988,0.00465029814448696,-3.14727000461377,-2.00754707226609,-0.804156571240972,"OAZ2","ornithine decarboxylase antizyme 2",TRUE
+"201365_at",0.51470556386048,0.0349273741746622,-2.24698484350596,-3.74070853178152,-0.627755534342839,"OAZ2","ornithine decarboxylase antizyme 2",TRUE
+"222075_s_at",0.622917527985155,0.0936269227923558,-1.75187327957804,-4.54612520342585,-1.15082089690215,"OAZ3","ornithine decarboxylase antizyme 3",TRUE
+"213863_s_at",0.774421352016308,0.290757371650339,-1.08230145317722,-5.38470678434939,-0.81114769322422,"OAZ3","ornithine decarboxylase antizyme 3",TRUE
+"228781_at",0.748760747870936,0.241863145541216,1.20250117115302,-5.25890672624097,0.701176954001109,"OBFC1","oligonucleotide/oligosaccharide binding fold containing 1",TRUE
+"219100_at",0.864894115958506,0.493953280889331,0.69553171300268,-5.70676720649509,0.289674775929228,"OBFC1","oligonucleotide/oligosaccharide binding fold containing 1",TRUE
+"234436_x_at",0.774230543658252,0.288563571094047,1.08736424587619,-5.37964471754325,0.37764806561566,"OBP2A","odorant binding protein 2A",TRUE
+"234841_x_at",0.883515015273005,0.541783792764327,0.619688428834272,-5.75435567691788,0.234395667942504,"OBP2A","odorant binding protein 2A",TRUE
+"220848_x_at",0.955904644595647,0.80048435112269,0.255774752208405,-5.90786959625166,0.139105302131235,"OBP2A","odorant binding protein 2A",TRUE
+"233860_s_at",0.862634144901168,0.485800766989024,0.708864730745483,-5.69785905664843,0.238668176001272,"OBP2A///OBP2B","odorant binding protein 2A///odorant binding protein 2B",TRUE
+"220959_s_at",0.91671872326659,0.647853987170782,-0.463036510856873,-5.83579188547424,-0.367739322035176,"OBP2A///OBP2B","odorant binding protein 2A///odorant binding protein 2B",TRUE
+"234722_x_at",0.741186481976394,0.231508956291062,1.23024162227708,-5.22823401729419,0.696114704272111,"OBP2B","odorant binding protein 2B",TRUE
+"233029_at",0.791707425459848,0.322449659674488,1.01202761654156,-5.45277813358156,0.921323808223508,"OBSCN","obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF",TRUE
+"220427_at",0.86373265375983,0.489236496744832,0.703230197249593,-5.70164331508703,0.510872788584225,"OBSCN","obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF",TRUE
+"229854_at",0.975242094553739,0.87982626033156,0.152944631902767,-5.92829648893351,0.0740186549112849,"OBSCN","obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF",TRUE
+"216085_at",0.744863302188406,0.236377774840023,1.21708300368128,-5.24285904360733,0.772347383050698,"OBSCN///DKFZP434C153","obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF///DKFZP434C153 protein",TRUE
+"213946_s_at",0.697429077307564,0.167976178427157,1.4254058881456,-4.99574916191586,1.1742567780866,"OBSL1","obscurin like 1",TRUE
+"227573_s_at",0.708894565317004,0.181121425624971,1.38076574836633,-5.05144649222441,0.774882560835275,"OBSL1","obscurin like 1",TRUE
+"212776_s_at",0.758230035295206,0.255200412983374,-1.16805430459833,-5.29614706474029,-0.700519868870593,"OBSL1","obscurin like 1",TRUE
+"212775_at",0.867717011547419,0.50064408271851,-0.684683057322832,-5.71389635261294,-0.36465589783575,"OBSL1","obscurin like 1",TRUE
+"227574_at",0.954387719376857,0.790098679231374,0.269421269759544,-5.90439034175335,0.185710588853262,"OBSL1","obscurin like 1",TRUE
+"238776_x_at",0.985498770484702,0.929738151496887,0.089182442120978,-5.93581036259989,0.030636005105467,"OBSL1","obscurin like 1",TRUE
+"214928_at",0.98687728101116,0.938643501272661,0.0778533615516859,-5.93673175119573,0.0553953370930218,"OBSL1","obscurin like 1",TRUE
+"206498_at",0.86880806912978,0.505187857956543,0.677362470917428,-5.71864651416304,0.474081906280611,"OCA2","OCA2 melanosomal transmembrane protein",TRUE
+"205441_at",0.89205696974366,0.562444095155252,-0.588051733034466,-5.77264383723396,-0.249267532457223,"OCEL1","occludin/ELL domain containing 1",TRUE
+"223011_s_at",0.721094750464234,0.197292846404963,-1.32924496121585,-5.11389390415818,-0.382111826653446,"OCIAD1","OCIA domain containing 1",TRUE
+"223010_s_at",0.736256800969852,0.221728008954626,-1.2573250870666,-5.1977062643838,-0.375726022032589,"OCIAD1","OCIA domain containing 1",TRUE
+"235537_at",0.736330422786726,0.22183986989234,-1.25701023538838,-5.19806443598879,-1.00336711103563,"OCIAD1","OCIA domain containing 1",TRUE
+"232644_x_at",0.738061563377262,0.224856031569904,-1.2485661575019,-5.20764160677259,-0.427337917197892,"OCIAD1","OCIA domain containing 1",TRUE
+"239748_x_at",0.947778780715578,0.761887499450174,-0.306763858983492,-5.89395251233787,-0.0984881516095282,"OCIAD1","OCIA domain containing 1",TRUE
+"225314_at",0.968451827985008,0.851964147774381,-0.1888052813665,-5.92233582972064,-0.0846498217245149,"OCIAD2","OCIA domain containing 2",TRUE
+"208274_at",0.783061975680449,0.305576777560458,1.04879907385164,-5.41767131087245,0.50275136057369,"OCLM","oculomedin",TRUE
+"231022_at",0.87045636854107,0.509154218718572,0.671002428183916,-5.7227337411893,0.39100004571171,"OCLN","occludin",TRUE
+"235937_at",0.944793138991092,0.751756391745194,-0.32028076421684,-5.88984379078847,-0.234692076905373,"OCLN","occludin",TRUE
+"209925_at",0.957017346544368,0.805443683440288,-0.249275941108077,-5.90946334872566,-0.166697551041235,"OCLN","occludin",TRUE
+"227492_at",0.980434477155705,0.908634575070082,0.116080319065388,-5.93312261053144,0.0640407642945267,"OCLN","occludin",TRUE
+"207944_at",0.813418501361393,0.363385195180757,0.928043637324914,-5.52867984700564,0.59886746102507,"OCM2","oncomodulin 2",TRUE
+"224270_at",0.934944350954831,0.711053607707431,0.37523524431689,-5.87133598824721,0.325361176441415,"OCR1","ovarian cancer-related protein 1",TRUE
+"203446_s_at",0.725836505745628,0.204929015206022,-1.30606146566567,-5.14134269323531,-0.446353648061081,"OCRL","OCRL, inositol polyphosphate-5-phosphatase",TRUE
+"208316_s_at",0.794443786143158,0.32642303897039,-1.00356525115934,-5.46069701999646,-0.301166550222806,"OCRL","OCRL, inositol polyphosphate-5-phosphatase",TRUE
+"220133_at",0.930374550176682,0.692188937115013,0.401099352457197,-5.86162676914331,0.241379498958562,"ODAM","odontogenic, ameloblast asssociated",TRUE
+"200790_at",0.64513208805899,0.116121170992857,1.63526909193586,-4.71493965203097,1.17160875738664,"ODC1","ornithine decarboxylase 1",TRUE
+"214485_at",0.734577729521114,0.218932783869013,1.26523253625338,-5.18868565118502,0.539244469488652,"ODF1","outer dense fiber of sperm tails 1",TRUE
+"210415_s_at",0.595936234743389,0.0724325492215842,-1.88628346602148,-4.34101138494286,-0.743639399843478,"ODF2","outer dense fiber of sperm tails 2",TRUE
+"225617_at",0.723649742218726,0.200195055804153,-1.32035272403088,-5.12447030875642,-0.42816727942316,"ODF2","outer dense fiber of sperm tails 2",TRUE
+"228577_x_at",0.68806049531767,0.157402780978921,1.46339321567236,-4.94721082694188,0.960999275929706,"ODF2L","outer dense fiber of sperm tails 2 like",TRUE
+"230926_s_at",0.769258076576208,0.275721688216521,1.11757229427833,-5.34900455806444,0.968750922986457,"ODF2L","outer dense fiber of sperm tails 2 like",TRUE
+"237420_at",0.78638420006208,0.311774986888531,-1.03512895403318,-5.4308544990232,-0.88051274295336,"ODF2L","outer dense fiber of sperm tails 2 like",TRUE
+"231909_x_at",0.957571530817866,0.809320613311114,0.244203177442037,-5.91067904697019,0.205100956939785,"ODF2L","outer dense fiber of sperm tails 2 like",TRUE
+"1553051_s_at",0.637485146909712,0.108664953529193,1.67161791084439,-4.66325821789138,1.03613684971782,"ODF3","outer dense fiber of sperm tails 3",TRUE
+"233795_at",0.713330901550199,0.188193202628265,-1.35780721026388,-5.07951915382573,-0.915338736735314,"ODF3","outer dense fiber of sperm tails 3",TRUE
+"238327_at",0.536422380101288,0.0432916166043323,2.14360418265908,-3.9196326138385,1.37829254240807,"ODF3B","outer dense fiber of sperm tails 3B",TRUE
+"235257_at",0.740270784944871,0.22875606113994,1.23777483015791,-5.21980022289351,0.627777840192895,"ODF3B","outer dense fiber of sperm tails 3B",TRUE
+"238326_at",0.740270784944871,0.228781963783742,-1.23770362803276,-5.21988014483795,-0.74147206840336,"ODF3B","outer dense fiber of sperm tails 3B",TRUE
+"243934_at",0.888432014077017,0.554524570871372,-0.60010554868572,-5.76578500727497,-0.269027698264269,"ODF3B","outer dense fiber of sperm tails 3B",TRUE
+"238325_s_at",0.93327969444489,0.704734987925957,0.383868409937653,-5.86816605830322,0.301220772454779,"ODF3B","outer dense fiber of sperm tails 3B",TRUE
+"236245_at",0.86486291642905,0.492895643064664,-0.697254254081086,-5.70562540481424,-0.522997649328141,"ODF3L1","outer dense fiber of sperm tails 3 like 1",TRUE
+"237620_at",0.812302873476553,0.356680926795246,0.94134125174079,-5.51706269595393,0.64458901848161,"ODF3L2","outer dense fiber of sperm tails 3 like 2",TRUE
+"1552409_a_at",0.606900628956089,0.0803387274802114,-1.8325844774114,-4.42426363479089,-0.888525616194902,"ODF4","outer dense fiber of sperm tails 4",TRUE
+"1552408_at",0.919695424525124,0.658674371763019,0.447759032024868,-5.84250207035207,0.238421021160199,"ODF4","outer dense fiber of sperm tails 4",TRUE
+"1564805_a_at",0.467673691528294,0.0245681856811684,2.41231264974076,-3.44432995790696,0.793000193233697,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1564783_x_at",0.517654151778308,0.0366838154300749,2.22353744734563,-3.78174022317386,1.40603417948436,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1565027_at",0.625490878792938,0.0966685340265223,1.73479615849806,-4.57139235266055,0.461992655838227,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1564590_a_at",0.637485146909712,0.10887728573831,-1.67055410592894,-4.66478304759081,-1.16699033810616,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1553076_at",0.689848451630875,0.158712354758649,1.45857852746055,-4.95342027265192,1.09895203959323,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1562591_a_at",0.724697226571437,0.202256347753428,1.3140979321554,-5.13187386298984,0.358496754478846,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1553075_a_at",0.831875452294783,0.407200352524192,0.84489549508071,-5.59784970684587,0.789039453830406,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1565026_a_at",0.853093296743962,0.4595547666941,-0.752697400034822,-5.66744062626312,-0.731412196115548,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1555708_a_at",0.872668627020452,0.516732608625532,-0.65892707277484,-5.73039222628761,-0.377983350316734,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1565111_x_at",0.888830748858811,0.555875560460118,0.598042985752863,-5.76696817747921,0.416107411880399,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"1565065_at",0.991689960875868,0.961104350825072,0.0493223236699886,-5.938498675817,0.033120925950898,"OFCC1","orofacial cleft 1 candidate 1",TRUE
+"203569_s_at",0.635916735157933,0.107209038472296,-1.67895991073498,-4.65271432217056,-0.573890414142824,"OFD1","OFD1, centriole and centriolar satellite protein",TRUE
+"241751_at",0.978999293602992,0.898475238948617,0.12905914254941,-5.93157408435174,0.0529271777585381,"OFD1","OFD1, centriole and centriolar satellite protein",TRUE
+"1554152_a_at",0.637485146909712,0.108487080613685,1.67251042474185,-4.66197834382904,0.542375383809453,"OGDH","oxoglutarate dehydrogenase",TRUE
+"1554151_at",0.744573608322482,0.235558186235454,1.21928359540707,-5.24042268567946,0.601404121833858,"OGDH","oxoglutarate dehydrogenase",TRUE
+"201282_at",0.949216032237554,0.77070345370036,0.295048996565202,-5.89737145245023,0.11271044841668,"OGDH","oxoglutarate dehydrogenase",TRUE
+"219277_s_at",0.727286289873957,0.207598439072072,-1.29811563881135,-5.15065635919638,-1.53334739230653,"OGDHL","oxoglutarate dehydrogenase-like",TRUE
+"225110_at",0.632949074657601,0.104025107550877,-1.69531503790489,-4.62910109111632,-0.474485609202809,"OGFOD1","2-oxoglutarate and iron dependent oxygenase domain containing 1",TRUE
+"221090_s_at",0.703896906014433,0.175359483435255,-1.40000353001357,-5.02762287709613,-0.429279757692912,"OGFOD1","2-oxoglutarate and iron dependent oxygenase domain containing 1",TRUE
+"225109_at",0.743553048228796,0.234246095623545,-1.22281864085403,-5.23650093459262,-0.417675115330881,"OGFOD1","2-oxoglutarate and iron dependent oxygenase domain containing 1",TRUE
+"225106_s_at",0.758189649141895,0.25507978843728,-1.16835975990073,-5.29582099456252,-0.341704917927478,"OGFOD1","2-oxoglutarate and iron dependent oxygenase domain containing 1",TRUE
+"241739_at",0.920119557710459,0.659761575427913,0.446230018589635,-5.8431614931481,0.252942251572396,"OGFOD1","2-oxoglutarate and iron dependent oxygenase domain containing 1",TRUE
+"219246_s_at",0.789378278298554,0.315832551999367,-1.02628347716166,-5.43930182497863,-0.311970082416299,"OGFOD2","2-oxoglutarate and iron dependent oxygenase domain containing 2",TRUE
+"219245_s_at",0.888603757551911,0.554783593143196,-0.59970989479828,-5.76601227546675,-0.214861913480572,"OGFOD2","2-oxoglutarate and iron dependent oxygenase domain containing 2",TRUE
+"44617_at",0.898139704572646,0.587145998363787,-0.551002044484911,-5.79288165482312,-0.175074857141345,"OGFOD2","2-oxoglutarate and iron dependent oxygenase domain containing 2",TRUE
+"219254_at",0.901042357811187,0.597332991334692,0.535949942502086,-5.80073848306143,0.225343078534225,"OGFOD3","2-oxoglutarate and iron dependent oxygenase domain containing 3",TRUE
+"64438_at",0.921312278448293,0.66463163013483,0.43939408626933,-5.84608258130712,0.110337864162039,"OGFOD3","2-oxoglutarate and iron dependent oxygenase domain containing 3",TRUE
+"53071_s_at",0.933298127911264,0.704783076735825,0.383802594465639,-5.86819049339644,0.130670382600876,"OGFOD3","2-oxoglutarate and iron dependent oxygenase domain containing 3",TRUE
+"211513_s_at",0.899331416659389,0.590051446021138,-0.546696026019963,-5.79515088353794,-0.243623715379584,"OGFR","opioid growth factor receptor",TRUE
+"210443_x_at",0.950980582261399,0.776210632905786,-0.287752356721664,-5.89943423836757,-0.0934529896584202,"OGFR","opioid growth factor receptor",TRUE
+"211512_s_at",0.957430653957785,0.807346863620562,-0.246784900569207,-5.91006343665036,-0.0967038798828668,"OGFR","opioid growth factor receptor",TRUE
+"202841_x_at",0.980067566136987,0.906375952237211,-0.118963924793493,-5.932792711009,-0.0446510940344851,"OGFR","opioid growth factor receptor",TRUE
+"219582_at",0.876278327062923,0.524942289111017,0.645955961226404,-5.73847019383982,0.590897083249128,"OGFRL1","opioid growth factor receptor like 1",TRUE
+"226810_at",0.961212424803935,0.82402361320669,-0.225023228617664,-5.91505086797806,-0.186893678995084,"OGFRL1","opioid growth factor receptor like 1",TRUE
+"238469_at",0.99886461451188,0.994905755786769,0.00645715818151318,-5.93966317272499,0.0061609148188122,"OGFRL1","opioid growth factor receptor like 1",TRUE
+"1561537_at",0.21219412234776,0.00249684367166903,3.4092549728122,-1.46232159740673,1.6378493200133,"OGFRP1","opioid growth factor receptor pseudogene 1",TRUE
+"215272_at",0.839519981963042,0.42791518608198,0.807584367641414,-5.62692109962257,0.402726704363428,"OGG1","8-oxoguanine DNA glycosylase",TRUE
+"205760_s_at",0.896118635245982,0.578343161555686,-0.564113299301831,-5.78586575066842,-0.222106133687356,"OGG1","8-oxoguanine DNA glycosylase",TRUE
+"205301_s_at",0.975196332002567,0.879292108688244,0.153630045719027,-5.92819425789339,0.051090862680784,"OGG1","8-oxoguanine DNA glycosylase",TRUE
+"222722_at",0.766086095192912,0.266501280851745,1.13989976183565,-5.3258801510327,0.884158803577936,"OGN","osteoglycin",TRUE
+"218730_s_at",0.970540753946729,0.859883062496086,0.17858933677733,-5.92416094445404,0.179542613049236,"OGN","osteoglycin",TRUE
+"220594_at",0.579119470758542,0.062286694501518,-1.96327876842187,-4.21872295346533,-0.98358400719975,"OGT","O-linked N-acetylglucosamine (GlcNAc) transferase",TRUE
+"209240_at",0.640067422642767,0.110386080897066,-1.66304496551381,-4.67552546298098,-0.449080305323157,"OGT","O-linked N-acetylglucosamine (GlcNAc) transferase",TRUE
+"229787_s_at",0.852409445602775,0.45832605591357,-0.754785339094899,-5.66594850517922,-0.327293580384169,"OGT","O-linked N-acetylglucosamine (GlcNAc) transferase",TRUE
+"207564_x_at",0.883470040615382,0.541601332284904,-0.61997063776875,-5.75418838265609,-0.208362370651484,"OGT","O-linked N-acetylglucosamine (GlcNAc) transferase",TRUE
+"207563_s_at",0.966641191718519,0.845021481212033,0.197778707803606,-5.92064925515894,0.06899170250556,"OGT","O-linked N-acetylglucosamine (GlcNAc) transferase",TRUE
+"212307_s_at",0.985498770484702,0.92976778363159,0.0891447261412825,-5.9358136372264,0.0343588001667907,"OGT","O-linked N-acetylglucosamine (GlcNAc) transferase",TRUE
+"213599_at",0.976371465776674,0.887004909074036,-0.143740255091725,-5.9296251500025,-0.0631372753780965,"OIP5","Opa interacting protein 5",TRUE
+"231808_at",0.936992192746977,0.718013457189517,0.365759433070635,-5.87473342387306,0.12731242164296,"OIP5-AS1","OIP5 antisense RNA 1",TRUE
+"225332_at",0.937113154905832,0.720694090734685,0.362118889005435,-5.87601588871706,0.201047812127761,"OIP5-AS1","OIP5 antisense RNA 1",TRUE
+"225225_at",0.940044918888428,0.731561277870932,0.347410621512572,-5.88106818249221,0.176888713415211,"OIP5-AS1","OIP5 antisense RNA 1",TRUE
+"230478_at",0.784498961298069,0.307716280888531,-1.04405844009223,-5.42226070849108,-0.849589145712977,"OIT3","oncoprotein induced transcript 3",TRUE
+"1555000_at",0.771855357662161,0.281913147795074,1.10288359158925,-5.36399655108373,0.535426258287656,"OK/SW-CL.36","OK/SW-CL.36",TRUE
+"1554971_at",0.434309499513877,0.019702152908951,2.51379296294141,-3.25668670874325,1.3808536268631,"OK/SW-CL.58","OK/SW-CL.58",TRUE
+"224525_s_at",0.960138290470901,0.819632660682676,0.230741826229533,-5.91378458781428,0.128164412600922,"OLA1","Obg-like ATPase 1",TRUE
+"219293_s_at",0.97928472590149,0.899477190806257,-0.127778149783087,-5.93173420410828,-0.035377611723824,"OLA1","Obg-like ATPase 1",TRUE
+"233126_s_at",0.66927199146331,0.135326586222939,1.54992403857274,-4.83281838872728,1.2315940206667,"OLAH","oleoyl-ACP hydrolase",TRUE
+"219975_x_at",0.737573517874932,0.223949242800968,1.25109566364349,-5.20477848421962,0.642752575455458,"OLAH","oleoyl-ACP hydrolase",TRUE
+"222945_x_at",0.928246500493356,0.684812321739008,-0.411288160307982,-5.85762704879633,-0.132459416687919,"OLAH","oleoyl-ACP hydrolase",TRUE
+"205591_at",0.406049718268978,0.0152944030578077,-2.62838675675532,-3.04004139500827,-5.48301340485797,"OLFM1","olfactomedin 1",TRUE
+"213131_at",0.622917527985155,0.0938978723338054,-1.75033291378396,-4.5484118236761,-3.7871721315365,"OLFM1","olfactomedin 1",TRUE
+"210924_at",0.859483694145165,0.476968778240547,-0.723455902412733,-5.68792575324292,-0.404224695126683,"OLFM1","olfactomedin 1",TRUE
+"223601_at",0.859084912590476,0.475855264340239,-0.725306669651586,-5.68665204257734,-0.413552977461899,"OLFM2","olfactomedin 2",TRUE
+"1554524_a_at",0.623503825356688,0.0942764481227345,1.74818705138306,-4.55159480650024,1.32884375925004,"OLFM3","olfactomedin 3",TRUE
+"1554526_at",0.785106775499404,0.310375066858729,-1.03819957340739,-5.42790681541126,-1.09300368809946,"OLFM3","olfactomedin 3",TRUE
+"212768_s_at",0.112843005548009,0.000594399370787869,4.00138108320355,-0.197710392827203,4.47259011502142,"OLFM4","olfactomedin 4",TRUE
+"217525_at",0.983167907106595,0.918025365956953,-0.104101521879532,-5.93440649391475,-0.0817336014637204,"OLFML1","olfactomedin like 1",TRUE
+"213075_at",0.345235484905341,0.00874457359272292,2.87555675532427,-2.55761039144097,3.26472298507066,"OLFML2A","olfactomedin like 2A",TRUE
+"213125_at",0.992376456171815,0.964547459188458,-0.04495300414809,-5.93869928485862,-0.0297116799936736,"OLFML2B","olfactomedin like 2B",TRUE
+"218162_at",0.96649413975112,0.843682580998338,0.199511131528184,-5.92031465856555,0.376740646627605,"OLFML3","olfactomedin like 3",TRUE
+"228170_at",0.761748280722165,0.260940103295166,-1.153641999991,-5.31144704223908,-0.860214983491774,"OLIG1","oligodendrocyte transcription factor 1",TRUE
+"213825_at",0.831013183269159,0.404989039799124,0.84894884200078,-5.59461762921992,0.624778480610013,"OLIG2","oligodendrocyte lineage transcription factor 2",TRUE
+"213824_at",0.87887877854929,0.532293539244221,0.634435076779948,-5.74551562434809,0.339599904841307,"OLIG2","oligodendrocyte lineage transcription factor 2",TRUE
+"1556371_at",0.877333806479767,0.526980582917996,0.642752788029299,-5.74044127722997,0.430062424630959,"OLIG3","oligodendrocyte transcription factor 3",TRUE
+"232230_at",0.792716268502624,0.324334181501964,-1.00800503418607,-5.45654988649025,-0.487702281098696,"OLMALINC","oligodendrocyte maturation-associated long intergenic non-coding RNA",TRUE
+"225457_s_at",0.730101539866086,0.21274255646452,-1.2830242039879,-5.16821278232409,-0.519909360670646,"OLMALINC///PP7080","oligodendrocyte maturation-associated long intergenic non-coding RNA///uncharacterized LOC25845",TRUE
+"210004_at",0.193943271908176,0.00201126356052923,3.49938321258122,-1.27216620716421,3.63552010738079,"OLR1","oxidized low density lipoprotein receptor 1",TRUE
+"226019_at",0.823074246722209,0.389757726362414,-0.877261679458289,-5.57163995933704,-0.292594910956769,"OMA1","OMA1 zinc metallopeptidase",TRUE
+"226020_s_at",0.91005849310518,0.625664173705178,0.494725167165671,-5.82117131892157,0.150644878038845,"OMA1///DAB1","OMA1 zinc metallopeptidase///DAB1, reelin adaptor protein",TRUE
+"205907_s_at",0.657015752622694,0.126030616127311,-1.58987863814692,-4.77824604029426,-0.848800407520552,"OMD","osteomodulin",TRUE
+"205908_s_at",0.982844899319041,0.916473917735317,0.106079409703034,-5.93420412254134,0.0791545199182337,"OMD","osteomodulin",TRUE
+"221361_at",0.67818193964437,0.145542462365825,1.50854853189972,-4.88817202308878,0.541254022361397,"OMP","olfactory marker protein",TRUE
+"210745_at",0.951568785371415,0.777943338942618,0.285459952483675,-5.90007173142624,0.222125181373098,"ONECUT1","one cut homeobox 1",TRUE
+"233446_at",0.678611044120554,0.146209748996407,-1.50592980143235,-4.89163526194283,-0.936504379378038,"ONECUT2","one cut homeobox 2",TRUE
+"239911_at",0.781007914293987,0.302746808149003,-1.05510590400561,-5.41153672892263,-0.654677967036508,"ONECUT2","one cut homeobox 2",TRUE
+"230271_at",0.855021564299387,0.467158399291207,-0.739850119922859,-5.67653560066773,-0.568512354122237,"ONECUT2","one cut homeobox 2",TRUE
+"207676_at",0.860984256543785,0.481001629924644,0.716773966770565,-5.69249854971659,0.309072802137441,"ONECUT2","one cut homeobox 2",TRUE
+"233441_at",0.931370027472813,0.695885451257253,0.39600988479469,-5.8635876961365,0.223881707579059,"ONECUT2","one cut homeobox 2",TRUE
+"234109_x_at",0.90360437116293,0.604874495522831,-0.524887108324186,-5.80637804451102,-0.199140139317499,"ONECUT3","one cut homeobox 3",TRUE
+"238218_at",0.818686885011389,0.372312264416043,0.910589296816914,-5.54369745633756,0.657315514462703,"OOEP","oocyte expressed protein",TRUE
+"1557085_at",0.554642754132296,0.0511805645952247,-2.06149042172631,-4.05795718103665,-1.42104514830683,"OOSP2","oocyte secreted protein 2",TRUE
+"212214_at",0.77480482329936,0.291210170541264,1.0812599197945,-5.38574555412454,0.352764342296657,"OPA1","OPA1, mitochondrial dynamin like GTPase",TRUE
+"241027_at",0.881875934621979,0.538838658358361,0.624249847800188,-5.75164266317491,0.236085817132153,"OPA1","OPA1, mitochondrial dynamin like GTPase",TRUE
+"214306_at",0.931582451098271,0.697820145167821,0.393350388533025,-5.8646025648808,0.151663140798721,"OPA1","OPA1, mitochondrial dynamin like GTPase",TRUE
+"212213_x_at",0.932830928398943,0.703698833654382,0.3852869349392,-5.86763840331759,0.103491939544968,"OPA1","OPA1, mitochondrial dynamin like GTPase",TRUE
+"206357_at",0.77480482329936,0.291187577684978,1.08131186055066,-5.38569377233656,0.407255548569488,"OPA3","optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)",TRUE
+"229624_at",0.916919564257648,0.648626660526909,-0.461941886986524,-5.83628000316388,-0.174272001150396,"OPA3","optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)",TRUE
+"238630_at",0.955904644595647,0.800773294330152,-0.255395808862169,-5.90796364648317,-0.226306235140575,"OPA3","optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)",TRUE
+"239575_at",0.952613441433926,0.782735808782713,0.279127505728904,-5.90180642400751,0.0877357595075443,"OPALIN","oligodendrocytic myelin paranodal and inner loop protein",TRUE
+"206215_at",0.803583569469174,0.341960754650916,-0.971141789825948,-5.49047849277506,-0.611604356312372,"OPCML","opioid binding protein/cell adhesion molecule like",TRUE
+"214111_at",0.967267970852571,0.847020684197154,0.195193058616642,-5.92114323439375,0.174189788822983,"OPCML","opioid binding protein/cell adhesion molecule like",TRUE
+"206323_x_at",0.937203701144735,0.721137259319044,0.361517507141839,-5.8762265201727,0.102362130798591,"OPHN1","oligophrenin 1",TRUE
+"222025_s_at",0.812302873476553,0.359860233874821,0.93501451497201,-5.52260883854402,0.783882199886644,"OPLAH","5-oxoprolinase (ATP-hydrolysing)",TRUE
+"221327_s_at",0.960664106415106,0.821312338563055,-0.228553363529031,-5.914272917995,-0.135944674262594,"OPN1MW3///OPN1MW2///OPN1LW///OPN1MW","opsin 1 (cone pigments), medium-wave-sensitive 3///opsin 1 (cone pigments), medium-wave-sensitive 2///opsin 1 (cone pigments), long-wave-sensitive///opsin 1 (cone pigments), medium-wave-sensitive",TRUE
+"208036_at",0.980009054680439,0.905431324662201,0.120170245048694,-5.93265230349912,0.0732145277389842,"OPN1SW","opsin 1 (cone pigments), short-wave-sensitive",TRUE
+"224392_s_at",0.948815741515659,0.767191497332708,0.299710629872462,-5.89602677839181,0.251236166036723,"OPN3","opsin 3",TRUE
+"219032_x_at",0.993892931327222,0.971375594921858,0.0362906376921768,-5.93904203390736,0.0305407469273451,"OPN3","opsin 3",TRUE
+"234226_at",0.859502367311367,0.47728649960908,0.722928282829597,-5.68828829797782,0.217401868709869,"OPN4","opsin 4",TRUE
+"1568914_at",0.631011867940957,0.102135527091552,1.70522333195051,-4.61471185994969,1.05880389767951,"OPN5","opsin 5",TRUE
+"233657_at",0.967872389554844,0.848700612207186,0.193021393510713,-5.92155311910785,0.0590780770999482,"OPN5","opsin 5",TRUE
+"207792_at",0.77938352158119,0.300554930699787,1.06001954243835,-5.40673441523464,0.662038450250195,"OPRD1","opioid receptor delta 1",TRUE
+"207553_at",0.246981768922011,0.00338924239005538,-3.28110209663779,-1.73056494835352,-1.22955395389291,"OPRK1","opioid receptor kappa 1",TRUE
+"229944_at",0.809109571194383,0.352259964185652,0.950202317267961,-5.50923724148099,0.798268541285735,"OPRK1","opioid receptor kappa 1",TRUE
+"206563_s_at",0.729083413548563,0.210639559274351,-1.28915934744905,-5.16109659800683,-0.785014817008248,"OPRL1","opioid related nociceptin receptor 1",TRUE
+"206564_at",0.851319596585235,0.455354185905652,0.759849338125025,-5.662313333989,0.314265631592155,"OPRL1","opioid related nociceptin receptor 1",TRUE
+"207989_at",0.771011793494937,0.279905131944783,1.10762151816562,-5.35918002552741,1.11473973161627,"OPRM1","opioid receptor mu 1",TRUE
+"207994_s_at",0.896159990898752,0.579205271870415,-0.562824856043238,-5.7865622952995,-0.261536017451705,"OPRM1","opioid receptor mu 1",TRUE
+"211359_s_at",0.931582451098271,0.698302099250144,0.392688327766724,-5.86485416118468,0.192502842186461,"OPRM1","opioid receptor mu 1",TRUE
+"208004_at",0.940044918888428,0.731352425324372,0.347692548936598,-5.88097328607559,0.100737298896527,"OPRPN","opiorphin prepropeptide",TRUE
+"223884_at",0.931582451098271,0.698034666639263,-0.393055678109006,-5.86471461228966,-0.131789142966092,"OPTC","opticin",TRUE
+"202074_s_at",0.55074985379986,0.0490926323606793,2.08205245153626,-4.02364563786788,1.42964413512324,"OPTN","optineurin",TRUE
+"202073_at",0.56559911410714,0.0565814523525427,2.01158778942369,-4.14029794526163,1.51712422057696,"OPTN","optineurin",TRUE
+"1567250_at",0.832792886465252,0.409895299994791,0.839974564155068,-5.60175417759805,0.520258389292756,"OR10A3","olfactory receptor family 10 subfamily A member 3",TRUE
+"1567251_at",0.885029460971826,0.545618546844392,0.613768937427505,-5.7578478468536,0.456506168166996,"OR10A3","olfactory receptor family 10 subfamily A member 3",TRUE
+"1555655_at",0.990533424678243,0.952089676581906,0.0607668704812254,-5.93788510535582,0.0328398265913128,"OR10A4","olfactory receptor family 10 subfamily A member 4",TRUE
+"1555651_at",0.769258076576208,0.275475208201111,1.1181619945322,-5.34839901118445,0.477683176975842,"OR10A5","olfactory receptor family 10 subfamily A member 5",TRUE
+"221339_at",0.306787493213918,0.00613436009608177,-3.02892403950778,-2.2493452209532,-0.885313004510753,"OR10C1","olfactory receptor family 10 subfamily C member 1 (gene/pseudogene)",TRUE
+"1567255_at",0.790177425636572,0.31933718146988,1.01870737737686,-5.44648486156261,0.377102823002373,"OR10D1P","olfactory receptor family 10 subfamily D member 1 pseudogene",TRUE
+"1567254_at",0.955892698633978,0.799601862540117,0.256932355918355,-5.90758143155039,0.119932949586106,"OR10D1P","olfactory receptor family 10 subfamily D member 1 pseudogene",TRUE
+"1567253_at",0.615637099066718,0.0860340818624456,1.79667852406209,-4.47896860878122,0.891260055494193,"OR10D3","olfactory receptor family 10 subfamily D member 3 (putative)",TRUE
+"1567252_at",0.861357981297227,0.481782395354458,0.715484112587009,-5.69337661569442,0.541249406735419,"OR10D3","olfactory receptor family 10 subfamily D member 3 (putative)",TRUE
+"208558_at",0.68529926526524,0.153898695148642,1.47643762919774,-4.93030436819219,0.807260304308772,"OR10H1","olfactory receptor family 10 subfamily H member 1",TRUE
+"208543_at",0.990810941805126,0.954451213888152,0.0577680490138318,-5.93805820995469,0.0297826819172489,"OR10H2","olfactory receptor family 10 subfamily H member 2",TRUE
+"208520_at",0.580630437263151,0.0632327156143842,1.95565007635102,-4.2309892914865,1.26921967698865,"OR10H3","olfactory receptor family 10 subfamily H member 3",TRUE
+"221346_at",0.831957210365167,0.408174945015078,0.843113518650935,-5.59926605991201,0.496107386190007,"OR10J1","olfactory receptor family 10 subfamily J member 1",TRUE
+"221343_at",0.657571067962164,0.126366697962112,1.58839218142012,-4.7802957977761,0.672416860123829,"OR11A1","olfactory receptor family 11 subfamily A member 1",TRUE
+"221344_at",0.487765518929235,0.0289019014516688,-2.33655580588499,-3.5816330591406,-0.762758153892708,"OR12D2","olfactory receptor family 12 subfamily D member 2 (gene/pseudogene)",TRUE
+"221431_s_at",0.959451355429682,0.816644418352795,-0.234638083262489,-5.91290372491401,-0.120942796040766,"OR12D3","olfactory receptor family 12 subfamily D member 3",TRUE
+"208098_at",0.841420204214686,0.432151666594542,-0.800093875610297,-5.63260898339412,-0.544392041805927,"OR12D3///OR5V1","olfactory receptor family 12 subfamily D member 3///olfactory receptor family 5 subfamily V member 1",TRUE
+"1567298_at",0.708713388831643,0.180772143038795,1.38191796745404,-5.05002730133238,1.06838632220275,"OR13C4","olfactory receptor family 13 subfamily C member 4",TRUE
+"1567297_at",0.958587459575795,0.81232641316747,0.24027475245253,-5.91160342762003,0.165738978743001,"OR13C4","olfactory receptor family 13 subfamily C member 4",TRUE
+"234545_at",0.901677162938587,0.598528930489806,0.534191101185625,-5.8016427486752,0.161022478955149,"OR14J1","olfactory receptor family 14 subfamily J member 1",TRUE
+"221388_at",0.884338493988207,0.543461790544193,-0.617095466002324,-5.75588935697091,-0.26428156121304,"OR1A1","olfactory receptor family 1 subfamily A member 1",TRUE
+"221445_at",0.605074025447346,0.0789619082003231,-1.84159490465192,-4.41041372697473,-1.16525578507135,"OR1A2","olfactory receptor family 1 subfamily A member 2",TRUE
+"1567054_at",0.538128506818324,0.0437743475354462,-2.13820732120577,-3.92882935440561,-1.24130530066727,"OR1C1","olfactory receptor family 1 subfamily C member 1",TRUE
+"1567055_at",0.812896635201594,0.361739369577483,0.93129271742819,-5.5258553867799,0.525922674969935,"OR1C1","olfactory receptor family 1 subfamily C member 1",TRUE
+"221464_at",0.886783047600321,0.550125658940939,-0.60683968698841,-5.76189464810248,-0.171614917013698,"OR1D2","olfactory receptor family 1 subfamily D member 2",TRUE
+"221341_s_at",0.503066995427577,0.0325657265148455,2.28026767108754,-3.68202502155513,1.52065148560432,"OR1D5","olfactory receptor family 1 subfamily D member 5",TRUE
+"214515_at",0.9330573785522,0.704320603311651,0.38443561800541,-5.86795530163998,0.25466680692415,"OR1E1","olfactory receptor family 1 subfamily E member 1",TRUE
+"208587_s_at",0.782452900355118,0.304637858067844,1.05088692448952,-5.41564414015728,0.347622517671475,"OR1E2///OR1E1","olfactory receptor family 1 subfamily E member 2///olfactory receptor family 1 subfamily E member 1",TRUE
+"221402_at",0.658590024406624,0.126819938460206,1.58639274396527,-4.78305057307084,0.637586862055324,"OR1F1","olfactory receptor family 1 subfamily F member 1",TRUE
+"217308_at",0.817889575750373,0.370785480521619,0.913554609311995,-5.54116465279782,0.508597734020163,"OR1F2P","olfactory receptor family 1 subfamily F member 2 pseudogene",TRUE
+"221375_at",0.97897951922649,0.89815440859001,0.129469369951438,-5.93152247020827,0.0605020119682793,"OR1G1","olfactory receptor family 1 subfamily G member 1",TRUE
+"234403_at",0.698445705579474,0.169689679130446,1.41943210329499,-5.0032871526843,0.379686993140802,"OR1I1","olfactory receptor family 1 subfamily I member 1",TRUE
+"1567257_at",0.315093142651413,0.00675191420476347,2.98765219395116,-2.33289745783408,1.85524336094146,"OR1J2","olfactory receptor family 1 subfamily J member 2",TRUE
+"1567256_at",0.971735822349954,0.864884871019951,0.172146738856663,-5.92525990769255,0.156279266697405,"OR1J2","olfactory receptor family 1 subfamily J member 2",TRUE
+"1567284_at",0.723649742218726,0.200127291486972,1.32055919934399,-5.12422540615647,0.783965782171124,"OR1J4","olfactory receptor family 1 subfamily J member 4",TRUE
+"1567282_at",0.80392795268584,0.34252403580826,-0.969985551328373,-5.49152405967867,-0.745101207933813,"OR1J4","olfactory receptor family 1 subfamily J member 4",TRUE
+"1567065_at",0.762469810007018,0.261938188227925,1.15115982789144,-5.31406525822385,0.388757596549059,"OR1Q1","olfactory receptor family 1 subfamily Q member 1",TRUE
+"1567064_at",0.840039213897998,0.428885337451617,0.805864998710108,-5.62823109942244,0.745771841668803,"OR1Q1","olfactory receptor family 1 subfamily Q member 1",TRUE
+"233493_at",0.821424121108148,0.383410753478698,-0.88927146290482,-5.56168189242421,-0.789081510307413,"OR2A4","olfactory receptor family 2 subfamily A member 4",TRUE
+"222290_at",0.7569746234637,0.252640998673186,-1.17455862815819,-5.28918765186051,-0.880635203627744,"OR2A9P///OR2A20P","olfactory receptor family 2 subfamily A member 9 pseudogene///olfactory receptor family 2 subfamily A member 20 pseudogene",TRUE
+"223971_at",0.957440336789825,0.808050731356604,-0.245864024931422,-5.91028375735197,-0.0850019061964487,"OR2A9P///OR2A20P","olfactory receptor family 2 subfamily A member 9 pseudogene///olfactory receptor family 2 subfamily A member 20 pseudogene",TRUE
+"216408_at",0.716749536957327,0.19275408943094,1.34335897086911,-5.09698422305012,0.637162047538636,"OR2B2","olfactory receptor family 2 subfamily B member 2",TRUE
+"234903_at",0.487553723496951,0.0287894315934618,2.3383853530194,-3.57834633103193,1.61821404803622,"OR2B3","olfactory receptor family 2 subfamily B member 3",TRUE
+"216522_at",0.495672562291005,0.03023443978492,-2.31536349840299,-3.61959673248405,-1.26421077490152,"OR2B6","olfactory receptor family 2 subfamily B member 6",TRUE
+"221460_at",0.897949253801113,0.586306000965474,0.552248924413178,-5.79222133342236,0.206572071256204,"OR2C1","olfactory receptor family 2 subfamily C member 1",TRUE
+"1555018_at",0.51531387545335,0.0358338823777934,-2.23475273659393,-3.76214638692397,-1.98293085208443,"OR2C3","olfactory receptor family 2 subfamily C member 3",TRUE
+"208526_at",0.983498417373669,0.91949678232062,-0.102226057027537,-5.93459487128003,-0.0767066124410967,"OR2F1","olfactory receptor family 2 subfamily F member 1 (gene/pseudogene)",TRUE
+"217302_at",0.97589003385521,0.884681231249687,0.146718215949739,-5.92920428100233,0.118042740473671,"OR2F2","olfactory receptor family 2 subfamily F member 2",TRUE
+"208525_s_at",0.567292616148537,0.0573072598362605,2.00520826471239,-4.15072780684988,1.6633315430532,"OR2F2///OR2F1","olfactory receptor family 2 subfamily F member 2///olfactory receptor family 2 subfamily F member 1 (gene/pseudogene)",TRUE
+"1567656_at",0.779854829728531,0.301166280187247,1.0586464931639,-5.40807837119291,0.885642609735616,"OR2H1","olfactory receptor family 2 subfamily H member 1",TRUE
+"1556987_s_at",0.916790160854655,0.648278918628581,0.462434451835845,-5.83606049733459,0.13158244792552,"OR2H1","olfactory receptor family 2 subfamily H member 1",TRUE
+"1556986_at",0.940567117317801,0.733952656985209,-0.344184567460493,-5.88214865096262,-0.0975031696037201,"OR2H1","olfactory receptor family 2 subfamily H member 1",TRUE
+"1567657_at",0.962905928655899,0.83183430757335,0.214869701124273,-5.91722125429452,0.0969806803973796,"OR2H1","olfactory receptor family 2 subfamily H member 1",TRUE
+"216817_s_at",0.9882620262439,0.944057978535588,0.0709704463787695,-5.93723053683935,0.0372442272993601,"OR2H1","olfactory receptor family 2 subfamily H member 1",TRUE
+"217081_at",0.783969326139111,0.307050155150538,1.04553190868106,-5.42083624902351,0.58565755568388,"OR2H2","olfactory receptor family 2 subfamily H member 2",TRUE
+"208573_s_at",0.94276746684157,0.743626699131404,0.331171462290822,-5.8864057816985,0.113572512724184,"OR2H2","olfactory receptor family 2 subfamily H member 2",TRUE
+"234760_at",0.924812035112346,0.67468536590925,0.425348571994802,-5.85194546080456,0.123963683427129,"OR2H4P","olfactory receptor family 2 subfamily H member 4 pseudogene",TRUE
+"216818_s_at",0.808257777979515,0.350843821736088,-0.953056619351867,-5.50670222193469,-0.353259812562728,"OR2J2","olfactory receptor family 2 subfamily J member 2",TRUE
+"208508_s_at",0.868313695469383,0.502717234832208,0.6813383158544,-5.7160727364017,0.577125319040022,"OR2J2","olfactory receptor family 2 subfamily J member 2",TRUE
+"217334_at",0.940040471233448,0.730592405013679,-0.348718733499518,-5.88062723116656,-0.197562841716892,"OR2J3","olfactory receptor family 2 subfamily J member 3",TRUE
+"1567273_at",0.934784679606929,0.710396527204383,0.376131653867004,-5.87101015288906,0.298095346255265,"OR2K2","olfactory receptor family 2 subfamily K member 2",TRUE
+"1567272_at",0.951378232063277,0.777563560639773,-0.285962272579159,-5.89993247439198,-0.203958446941203,"OR2K2","olfactory receptor family 2 subfamily K member 2",TRUE
+"1554706_at",0.76029267756668,0.258742752378344,1.15913151043371,-5.30563907373493,0.865200783726046,"OR2L13","olfactory receptor family 2 subfamily L member 13",TRUE
+"1567241_at",0.753461393191199,0.246688841326304,1.1898772439283,-5.27266391338034,0.927205220494929,"OR2L1P","olfactory receptor family 2 subfamily L member 1 pseudogene",TRUE
+"1567242_at",0.976140471115891,0.885298727279598,0.145926718798638,-5.92931698197151,0.0564708279236159,"OR2L1P","olfactory receptor family 2 subfamily L member 1 pseudogene",TRUE
+"1567240_x_at",0.81304218438764,0.36233021064028,0.930125181716121,-5.52687138299453,0.652712113166207,"OR2L2","olfactory receptor family 2 subfamily L member 2",TRUE
+"1567237_at",0.937113154905832,0.720794199151673,-0.361983029521018,-5.87606350315423,-0.248119664100806,"OR2L2","olfactory receptor family 2 subfamily L member 2",TRUE
+"1567238_at",0.991689960875868,0.961562900518944,0.0487403672092784,-5.9385264684206,0.03933875206046,"OR2L2","olfactory receptor family 2 subfamily L member 2",TRUE
+"1566288_at",0.792716268502624,0.324336339763172,1.0080004366396,-5.4565541895696,0.837932586727587,"OR2M4","olfactory receptor family 2 subfamily M member 4",TRUE
+"1566289_at",0.859347696655696,0.476381393668896,0.724431876373779,-5.6872544667911,0.527323234304449,"OR2M4","olfactory receptor family 2 subfamily M member 4",TRUE
+"221409_at",0.867692227847244,0.500458266783932,0.684983228015751,-5.71370053697343,0.219174971211891,"OR2S2","olfactory receptor family 2 subfamily S member 2 (gene/pseudogene)",TRUE
+"221451_s_at",0.85629081478032,0.470219943721341,0.734712341830335,-5.68013122421694,0.464279076587766,"OR2W1","olfactory receptor family 2 subfamily W member 1",TRUE
+"221353_at",0.789795896476304,0.318035720055168,1.0215139688986,-5.44382948936884,0.32736997630577,"OR3A1","olfactory receptor family 3 subfamily A member 1",TRUE
+"221386_at",0.614178202960275,0.0851179636227437,1.80231261528301,-4.47043646885542,1.09379273723879,"OR3A2","olfactory receptor family 3 subfamily A member 2",TRUE
+"221426_s_at",0.641326159307468,0.111818410098255,1.65599612061448,-4.68557585129399,0.672257157057453,"OR3A3","olfactory receptor family 3 subfamily A member 3",TRUE
+"234781_at",0.563430805981458,0.0556887073712629,2.01953517979075,-4.12727391756071,1.07826076760305,"OR3A3///OR1E2///OR1E1","olfactory receptor family 3 subfamily A member 3///olfactory receptor family 1 subfamily E member 2///olfactory receptor family 1 subfamily E member 1",TRUE
+"1567271_at",0.492341486607851,0.0295712856062849,2.32580044366731,-3.60092495063717,0.951935973456735,"OR4C1P","olfactory receptor family 4 subfamily C member 1 pseudogene",TRUE
+"1567270_at",0.932633693661011,0.702671017460462,0.386694840502357,-5.86711280143807,0.178135220349851,"OR4C1P","olfactory receptor family 4 subfamily C member 1 pseudogene",TRUE
+"1567069_at",0.79871392967667,0.333232070413434,0.989228305275271,-5.47397544572222,0.555866896525401,"OR4D1","olfactory receptor family 4 subfamily D member 1",TRUE
+"1567068_at",0.961981011884773,0.8271370137415,0.220973118325358,-5.91592856268276,0.0908435035622004,"OR4D1","olfactory receptor family 4 subfamily D member 1",TRUE
+"1555377_at",0.972405051071295,0.8668207888755,-0.169655188451443,-5.92567411561869,-0.114087418006511,"OR4D2","olfactory receptor family 4 subfamily D member 2",TRUE
+"234369_at",0.904381089098038,0.607700390475517,0.520758820500666,-5.80845320131419,0.158712371250768,"OR4F29///OR4F21///OR4F16///OR4F3","olfactory receptor family 4 subfamily F member 29///olfactory receptor family 4 subfamily F member 21///olfactory receptor family 4 subfamily F member 16///olfactory receptor family 4 subfamily F member 3",TRUE
+"234770_at",0.95560177469038,0.796556705291966,0.260929605856246,-5.90657644777549,0.16859106109851,"OR51A1P","olfactory receptor family 51 subfamily A member 1 pseudogene",TRUE
+"234486_at",0.501591596209182,0.0321974458623193,2.28565561863105,-3.67247720362967,0.677517093061754,"OR51B2","olfactory receptor family 51 subfamily B member 2 (gene/pseudogene)",TRUE
+"234469_at",0.853297110808539,0.460029389082536,-0.751891772712428,-5.66801531220935,-0.380550394751384,"OR51B4","olfactory receptor family 51 subfamily B member 4",TRUE
+"1570516_s_at",0.538508613666048,0.0439930886049165,2.13577948481893,-3.9329618431665,1.27134316091799,"OR51B5","olfactory receptor family 51 subfamily B member 5",TRUE
+"234775_at",0.851319596585235,0.455207051103884,0.760100567842561,-5.6621323911618,0.273112604143601,"OR51B5","olfactory receptor family 51 subfamily B member 5",TRUE
+"234526_at",0.8111749793648,0.355238327119838,0.94422450912204,-5.51452379030952,0.346524013681506,"OR51B6","olfactory receptor family 51 subfamily B member 6",TRUE
+"229768_at",0.889564089063817,0.557769293119081,0.59515620988183,-5.76861754092498,0.204638816195761,"OR51E1","olfactory receptor family 51 subfamily E member 1",TRUE
+"221424_s_at",0.608709711882903,0.0813416300876827,1.82610510392222,-4.43419297943459,0.596082935238821,"OR51E2","olfactory receptor family 51 subfamily E member 2",TRUE
+"236121_at",0.923110591956324,0.67036926823488,0.431367534032112,-5.84945592976136,0.252583670036222,"OR51E2","olfactory receptor family 51 subfamily E member 2",TRUE
+"232482_at",0.932625096890813,0.702332718492391,0.387158417368783,-5.86693932453022,0.284181677899813,"OR51E2","olfactory receptor family 51 subfamily E member 2",TRUE
+"234626_at",0.763356510523603,0.263013110937663,1.1484943644823,-5.31687129072071,0.588872124943468,"OR51I1","olfactory receptor family 51 subfamily I member 1",TRUE
+"234521_at",0.841346844002252,0.43172878094611,0.800839524820631,-5.63204500874969,0.255531766688199,"OR51I2","olfactory receptor family 51 subfamily I member 2",TRUE
+"234777_at",0.837609393049242,0.421790980055311,0.818494613425999,-5.61854746322721,0.416005809616659,"OR51M1","olfactory receptor family 51 subfamily M member 1",TRUE
+"221329_at",0.912722788750542,0.634258397840741,0.482392764857595,-5.82697372180269,0.252711660075804,"OR52A1","olfactory receptor family 52 subfamily A member 1",TRUE
+"234617_at",0.958723944343516,0.812825357547279,0.239623033536786,-5.91175533909884,0.0615998989353423,"OR52D1","olfactory receptor family 52 subfamily D member 1",TRUE
+"232829_at",0.855201634234614,0.467494585166971,0.739284972253213,-5.67693227721832,0.48333704648121,"OR52K3P","olfactory receptor family 52 subfamily K member 3 pseudogene",TRUE
+"1567022_at",0.552986220491716,0.0503817229143495,2.06926715823278,-4.04500627878281,1.4707714035943,"OR5AK4P","olfactory receptor family 5 subfamily AK member 4 pseudogene",TRUE
+"1567023_at",0.839781238235762,0.428538575348474,-0.806479276340794,-5.62776337778513,-0.39585104476165,"OR5AK4P","olfactory receptor family 5 subfamily AK member 4 pseudogene",TRUE
+"1566277_at",0.826140850652187,0.394302149533772,0.868740628735353,-5.57862906863167,0.650620634318326,"OR5E1P","olfactory receptor family 5 subfamily E member 1 pseudogene",TRUE
+"1566276_at",0.979918620726878,0.90413968224475,-0.121820010621292,-5.93245799177649,-0.118921802063366,"OR5E1P","olfactory receptor family 5 subfamily E member 1 pseudogene",TRUE
+"1567246_at",0.542397752248982,0.045526109428448,2.11906332434644,-3.96133421823342,2.00629448333284,"OR5H1","olfactory receptor family 5 subfamily H member 1",TRUE
+"1567247_at",0.841088238127348,0.430905473970501,0.802292512253272,-5.63094461781051,0.673118667085054,"OR5H1","olfactory receptor family 5 subfamily H member 1",TRUE
+"208521_at",0.645636413659377,0.116614605151228,1.63293360509029,-4.71823052763321,0.874747590332486,"OR5I1","olfactory receptor family 5 subfamily I member 1",TRUE
+"1567244_at",0.68033297785336,0.147715122565204,1.50005773775037,-4.89938347319255,1.32845620436677,"OR5J2","olfactory receptor family 5 subfamily J member 2",TRUE
+"1567245_at",0.7717895132349,0.281483410828052,1.10389549466078,-5.36296940125887,0.953926692605868,"OR5J2","olfactory receptor family 5 subfamily J member 2",TRUE
+"1567288_at",0.165155699955081,0.00133514072940367,3.66908077121467,-0.911377296561183,2.40894199885617,"OR5K1","olfactory receptor family 5 subfamily K member 1",TRUE
+"1567285_at",0.848739878684675,0.449215082018786,0.770373649101563,-5.65468501402069,0.323110247078639,"OR5L2","olfactory receptor family 5 subfamily L member 2",TRUE
+"1567286_at",0.872289159593181,0.515372870382262,0.661086383018142,-5.72903252522274,0.230333785806605,"OR5L2","olfactory receptor family 5 subfamily L member 2",TRUE
+"1552991_at",0.594005743610726,0.0709104902281397,1.89720481962882,-4.32387226535331,0.860959677482471,"OR5P2","olfactory receptor family 5 subfamily P member 2",TRUE
+"1553078_at",0.687545925823023,0.156509035279683,1.46669775363256,-4.94293940455237,1.09167048312528,"OR5P3","olfactory receptor family 5 subfamily P member 3",TRUE
+"234840_s_at",0.990810941805126,0.956637034919657,-0.0549928469145947,-5.93821060533905,-0.0374952891136839,"OR5V1","olfactory receptor family 5 subfamily V member 1",TRUE
+"221465_at",0.878110025868144,0.529947494435412,0.638102345196105,-5.74328618280216,0.432402531844595,"OR6A2","olfactory receptor family 6 subfamily A member 2",TRUE
+"234363_at",0.821962235882611,0.385189347392589,0.885892992406379,-5.56449588280813,0.431045719803454,"OR6B1","olfactory receptor family 6 subfamily B member 1",TRUE
+"1553061_at",0.97897951922649,0.898081345782431,0.129562794356788,-5.9315106928392,0.0380922251604523,"OR6W1P","olfactory receptor family 6 subfamily W member 1 pseudogene",TRUE
+"217316_at",0.985361089461736,0.927275989672471,-0.0923167666847869,-5.93553339335517,-0.0637668219229006,"OR7A10","olfactory receptor family 7 subfamily A member 10",TRUE
+"208509_s_at",0.497725944448536,0.0305470577400934,-2.31051609931798,-3.62825226784913,-1.10313913752831,"OR7A17","olfactory receptor family 7 subfamily A member 17",TRUE
+"208285_at",0.954577684533304,0.792488655201145,0.266276362671794,-5.90520807803003,0.100393116790245,"OR7A5","olfactory receptor family 7 subfamily A member 5",TRUE
+"216690_at",0.769258076576208,0.275962381138561,1.11699681039643,-5.34959523377501,0.583997399104272,"OR7C1","olfactory receptor family 7 subfamily C member 1",TRUE
+"208507_at",0.675662829199842,0.142271879077172,-1.52152777384169,-4.87093621356979,-0.521707682210645,"OR7C2","olfactory receptor family 7 subfamily C member 2",TRUE
+"1562337_at",0.873330973137109,0.51844776757236,-0.656207825195309,-5.73209844670114,-0.194446936203015,"OR7D2","olfactory receptor family 7 subfamily D member 2",TRUE
+"1566957_at",0.734577729521114,0.218947316794569,1.26519122417278,-5.18873290472016,0.856200610240372,"OR7E104P","olfactory receptor family 7 subfamily E member 104 pseudogene",TRUE
+"1566956_at",0.97304633500821,0.869345658221401,0.166407298627908,-5.92620501944869,0.0396890817090778,"OR7E104P","olfactory receptor family 7 subfamily E member 104 pseudogene",TRUE
+"216698_x_at",0.801527706887973,0.338264667432342,0.978761218127422,-5.48355996490437,0.297812473547829,"OR7E12P","olfactory receptor family 7 subfamily E member 12 pseudogene",TRUE
+"217551_at",0.948989397056643,0.769977436606023,0.296012132616155,-5.89709534352173,0.193339131519526,"OR7E14P","olfactory receptor family 7 subfamily E member 14 pseudogene",TRUE
+"222327_x_at",0.590570903980459,0.0682668488023363,1.91667193310111,-4.29315108004669,0.484148869765004,"OR7E156P","olfactory receptor family 7 subfamily E member 156 pseudogene",TRUE
+"216536_at",0.841420204214686,0.432234441520361,0.799947976365435,-5.6327192770876,0.356808511230463,"OR7E19P","olfactory receptor family 7 subfamily E member 19 pseudogene",TRUE
+"215463_at",0.734730148360473,0.219530315957608,1.26353569190204,-5.190625447161,0.45873267041735,"OR7E24","olfactory receptor family 7 subfamily E member 24",TRUE
+"215770_at",0.811263413918865,0.355368807839502,-0.943963399022835,-5.51475400894966,-0.496628881214547,"OR7E2P","olfactory receptor family 7 subfamily E member 2 pseudogene",TRUE
+"217499_x_at",0.906507435035949,0.614483177788318,0.510887096038405,-5.81335065172417,0.199181774223037,"OR7E37P","olfactory receptor family 7 subfamily E member 37 pseudogene",TRUE
+"222304_x_at",0.835952408568777,0.417061179399959,0.82698883505504,-5.61195523538656,0.551163989230043,"OR7E47P","olfactory receptor family 7 subfamily E member 47 pseudogene",TRUE
+"1568939_at",0.860501161621956,0.479960556466816,0.718495757229179,-5.69132409889182,0.53479906974322,"OR8B2","olfactory receptor family 8 subfamily B member 2",TRUE
+"1555212_at",0.724970327905974,0.203042899798088,1.31172430453079,-5.13467566037694,0.631457411510408,"OR8B8","olfactory receptor family 8 subfamily B member 8",TRUE
+"1555661_at",0.83149082353763,0.406158725113677,0.846803048439276,-5.59633045021711,0.249526884104224,"OR8D1","olfactory receptor family 8 subfamily D member 1",TRUE
+"234766_at",0.924812035112346,0.674662802036321,-0.425379996477241,-5.85193255243362,-0.260129934256147,"OR8D2","olfactory receptor family 8 subfamily D member 2 (gene/pseudogene)",TRUE
+"1567059_at",0.539609110035715,0.044446673875329,-2.13077957695025,-3.94146298821376,-1.74576083058811,"OR8G1","olfactory receptor family 8 subfamily G member 1 (gene/pseudogene)",TRUE
+"1567060_at",0.813065886130395,0.362781273773701,0.929234712916291,-5.52764548618106,0.578861570039238,"OR8G1","olfactory receptor family 8 subfamily G member 1 (gene/pseudogene)",TRUE
+"1567058_at",0.290430545694223,0.00503798940254048,3.11317499951591,-2.07752961494442,1.99698258507617,"OR8G2","olfactory receptor family 8 subfamily G member 2",TRUE
+"1567056_at",0.955892698633978,0.799138640658147,-0.257540130374812,-5.90742961935113,-0.196592884050291,"OR8G2","olfactory receptor family 8 subfamily G member 2",TRUE
+"1567248_at",0.736020435324742,0.221197938767262,1.2588187158892,-5.19600608222528,0.524852245222473,"OR9A1P","olfactory receptor family 9 subfamily A member 1 pseudogene",TRUE
+"1567249_at",0.802340231442685,0.340101274877287,-0.974967989278129,-5.48701042324664,-0.751318509586173,"OR9A1P","olfactory receptor family 9 subfamily A member 1 pseudogene",TRUE
+"226531_at",0.967701855457407,0.84817224262798,0.193704320953252,-5.92142471443303,0.0581074635166594,"ORAI1","ORAI calcium release-activated calcium modulator 1",TRUE
+"230347_at",0.731471659341929,0.214578398613355,1.27770658898894,-5.17435731665883,0.421958267531545,"ORAI2","ORAI calcium release-activated calcium modulator 2",TRUE
+"218812_s_at",0.791211889207316,0.321521776562143,1.01401424045861,-5.45091036924668,0.639766951460736,"ORAI2","ORAI calcium release-activated calcium modulator 2",TRUE
+"218811_at",0.844844378596734,0.441868675818056,0.783082978336178,-5.64534093923293,0.316995508785383,"ORAI2","ORAI calcium release-activated calcium modulator 2",TRUE
+"217529_at",0.861659105448003,0.482423937199801,0.714425170478816,-5.69409636357076,0.344805976452408,"ORAI2","ORAI calcium release-activated calcium modulator 2",TRUE
+"231406_at",0.94632739401154,0.757429653516468,0.312704173268755,-5.89216845298181,0.18497843529655,"ORAI2","ORAI calcium release-activated calcium modulator 2",TRUE
+"1558426_x_at",0.99783553534859,0.989930825964061,-0.0127633500700964,-5.93960413696429,-0.00444233824793194,"ORAI2","ORAI calcium release-activated calcium modulator 2",TRUE
+"221864_at",0.679430772812099,0.14673122514745,-1.50389009107202,-4.89432941661918,-0.856081567294403,"ORAI3","ORAI calcium release-activated calcium modulator 3",TRUE
+"228676_at",0.95442332217412,0.790490492062178,0.268905504050951,-5.90452510438406,0.175124416880953,"ORAOV1","oral cancer overexpressed 1",TRUE
+"243531_at",0.986421906591669,0.936128644689025,0.0810515523759566,-5.93648429702433,0.075251163178434,"ORAOV1","oral cancer overexpressed 1",TRUE
+"205085_at",0.906878681039516,0.615107176885158,0.509981515237726,-5.81379534277481,0.220715436610304,"ORC1","origin recognition complex subunit 1",TRUE
+"204853_at",0.817136258846902,0.369553329172516,-0.915953600205493,-5.53911001225943,-0.302738002240444,"ORC2","origin recognition complex subunit 2",TRUE
+"235423_at",0.942684843065067,0.743403840314968,0.331470578323164,-5.88630975070529,0.131786843006905,"ORC2","origin recognition complex subunit 2",TRUE
+"210028_s_at",0.659872040446785,0.127701985550388,1.58251863271237,-4.78838051482148,0.70727400762879,"ORC3","origin recognition complex subunit 3",TRUE
+"203352_at",0.620912785033482,0.0906461855279896,-1.76907633007639,-4.52048727544449,-0.742859252530906,"ORC4","origin recognition complex subunit 4",TRUE
+"203351_s_at",0.774230543658252,0.286721324478152,-1.09163719339893,-5.37535599764668,-0.341716948465971,"ORC4","origin recognition complex subunit 4",TRUE
+"204957_at",0.727822268767891,0.208056652416502,-1.29675969807825,-5.15224090473965,-0.435655961995394,"ORC5","origin recognition complex subunit 5",TRUE
+"211212_s_at",0.834454640870101,0.412724540948903,-0.83483048612643,-5.60581292583626,-0.274868547006532,"ORC5","origin recognition complex subunit 5",TRUE
+"211213_at",0.970274748961658,0.858700855924011,0.180113202945266,-5.92389512078691,0.157397138229467,"ORC5","origin recognition complex subunit 5",TRUE
+"219105_x_at",0.598790786356002,0.0757330313972638,-1.86327407512537,-4.37689259843566,-0.621097703432177,"ORC6","origin recognition complex subunit 6",TRUE
+"234806_at",0.831875452294783,0.407759471423124,-0.843872852189096,-5.59866286660788,-0.69388476963654,"ORF1","uncharacterized protein, clone pT-Adv JuaX22",TRUE
+"234855_at",0.86633226196296,0.497251742934095,-0.690173107018965,-5.71030196728911,-0.435339394318406,"ORF1","uncharacterized protein, clone pT-Adv JuaX22",TRUE
+"205040_at",0.988737747949649,0.945777058690904,-0.068785892394697,-5.93737920477964,-0.0605835959035286,"ORM1","orosomucoid 1",TRUE
+"205041_s_at",0.523369751179323,0.0388291857524147,-2.19624604247335,-3.82916967810323,-2.23637042348587,"ORM2///ORM1","orosomucoid 2///orosomucoid 1",TRUE
+"214465_at",0.865540137051525,0.495403988091274,0.693172419382108,-5.70832671101388,0.260829326886462,"ORM2///ORM1","orosomucoid 2///orosomucoid 1",TRUE
+"227548_at",0.803487298448767,0.341496510732857,-0.972095715400311,-5.48961501829422,-0.515544772804448,"ORMDL1","ORMDL sphingolipid biosynthesis regulator 1",TRUE
+"223187_s_at",0.851733415458562,0.456699149629535,-0.757555099051317,-5.66396309326009,-0.249644350485758,"ORMDL1","ORMDL sphingolipid biosynthesis regulator 1",TRUE
+"228801_at",0.988634593719643,0.945213869009773,-0.0695015381435422,-5.93733101377384,-0.0262475655971919,"ORMDL1","ORMDL sphingolipid biosynthesis regulator 1",TRUE
+"218556_at",0.721189044511851,0.197421791114931,-1.3288477176533,-5.114367660248,-0.47474528522071,"ORMDL2","ORMDL sphingolipid biosynthesis regulator 2",TRUE
+"235136_at",0.69910704334777,0.17042858363712,-1.41687096716232,-5.00651094998624,-2.07648948078607,"ORMDL3","ORMDL sphingolipid biosynthesis regulator 3",TRUE
+"223259_at",0.755639383619058,0.249785463387835,-1.18187367833097,-5.28132043584753,-1.070167444283,"ORMDL3","ORMDL sphingolipid biosynthesis regulator 3",TRUE
+"200714_x_at",0.631294544151106,0.102357477113274,-1.70405146912602,-4.61641697132206,-0.668289411277843,"OS9","OS9, endoplasmic reticulum lectin",TRUE
+"215399_s_at",0.687545925823023,0.156497108002843,-1.46674195684915,-4.94288221488759,-0.645768824269448,"OS9","OS9, endoplasmic reticulum lectin",TRUE
+"201799_s_at",0.68680805784522,0.155357168193255,-1.47097930313677,-4.9373935034356,-0.501836702696043,"OSBP","oxysterol binding protein",TRUE
+"1563051_at",0.841420204214686,0.432265028795528,0.799894067551521,-5.63276002510041,0.365776608118811,"OSBP","oxysterol binding protein",TRUE
+"201800_s_at",0.852546356114556,0.458560519199489,-0.75438665871923,-5.66623371959873,-0.269781412329536,"OSBP","oxysterol binding protein",TRUE
+"221237_s_at",0.174167700159084,0.00153852240897226,3.61049657921191,-1.03629301442301,1.92783608970706,"OSBP2","oxysterol binding protein 2",TRUE
+"1569617_at",0.412444326023181,0.0165128601676222,2.59389364586143,-3.10575790842219,1.6468695978019,"OSBP2","oxysterol binding protein 2",TRUE
+"223432_at",0.571677937624457,0.0592849815397787,1.98818222083975,-4.17845491969303,0.811554955689837,"OSBP2","oxysterol binding protein 2",TRUE
+"219073_s_at",0.760325881249847,0.259003258445373,1.15847890524957,-5.30633080547838,0.481136397297284,"OSBPL10","oxysterol binding protein like 10",TRUE
+"231656_x_at",0.789824589976275,0.318667349395879,1.02015086325051,-5.44511997558052,0.318532907237802,"OSBPL10","oxysterol binding protein like 10",TRUE
+"217017_at",0.835952408568777,0.416976505452049,0.827141451300129,-5.6118362096686,0.610699869367689,"OSBPL10","oxysterol binding protein like 10",TRUE
+"216755_at",0.865885012497452,0.496221210240827,0.6918451029368,-5.70920185018107,0.399898980017785,"OSBPL10","oxysterol binding protein like 10",TRUE
+"222818_at",0.933609099853387,0.706287501099869,-0.381744473714258,-5.86895252068878,-0.297605825632631,"OSBPL10","oxysterol binding protein like 10",TRUE
+"218304_s_at",0.944701641661959,0.751286183467831,-0.320909576220003,-5.88964838103039,-0.109856882665973,"OSBPL11","oxysterol binding protein like 11",TRUE
+"222586_s_at",0.947778780715578,0.762087483333933,-0.306497635394021,-5.89403167370195,-0.0810159644545294,"OSBPL11","oxysterol binding protein like 11",TRUE
+"229527_s_at",0.981488198026236,0.91198395852838,-0.111805976453598,-5.93359674442837,-0.0700924254648259,"OSBPL11","oxysterol binding protein like 11",TRUE
+"209485_s_at",0.487765518929235,0.0289065756008825,2.33647991327712,-3.58176936623811,1.56736864291498,"OSBPL1A","oxysterol binding protein like 1A",TRUE
+"208158_s_at",0.559065200216332,0.0528144465768179,2.04591685090876,-4.08379659447123,1.13166100259008,"OSBPL1A","oxysterol binding protein like 1A",TRUE
+"1554646_at",0.721658263642493,0.197874117982546,1.32745582405269,-5.11602670405095,0.464314041715394,"OSBPL1A","oxysterol binding protein like 1A",TRUE
+"209222_s_at",0.735413789306046,0.22047182744533,-1.26086920518809,-5.19366921503554,-0.525300139493758,"OSBPL2","oxysterol binding protein like 2",TRUE
+"209221_s_at",0.841967750949524,0.434412617272788,-0.796114913712492,-5.6356101362705,-0.274432355489346,"OSBPL2","oxysterol binding protein like 2",TRUE
+"209626_s_at",0.559434208511607,0.0539971264473465,2.03491017679459,-4.10198102995251,2.05560573980299,"OSBPL3","oxysterol binding protein like 3",TRUE
+"209627_s_at",0.637236149092845,0.108134924394758,1.67428109666733,-4.65943764810016,2.15710971953486,"OSBPL3","oxysterol binding protein like 3",TRUE
+"223464_at",0.965235510102031,0.838002728733849,-0.206867399485496,-5.91886151071005,-0.154341850271693,"OSBPL5","oxysterol binding protein like 5",TRUE
+"233734_s_at",0.9882620262439,0.944176592645201,0.0708197039878822,-5.93724094470122,0.0414782122307766,"OSBPL5","oxysterol binding protein like 5",TRUE
+"236261_at",0.562894650172193,0.055551836240301,2.02076364134085,-4.12525769227143,0.628692369826116,"OSBPL6","oxysterol binding protein like 6",TRUE
+"238575_at",0.710842845257879,0.184275486596465,1.37044005367994,-5.06412076534107,1.14236412796838,"OSBPL6","oxysterol binding protein like 6",TRUE
+"223805_at",0.728385463227073,0.209842021644966,1.29149841355778,-5.15837590191629,0.731078136939674,"OSBPL6","oxysterol binding protein like 6",TRUE
+"210344_at",0.527546822913581,0.0400578205455213,2.18122704265518,-3.85511784371061,1.08895002036559,"OSBPL7","oxysterol binding protein like 7",TRUE
+"227946_at",0.887948692739633,0.553439080498333,0.60176467650193,-5.76483040878495,0.277962565174523,"OSBPL7","oxysterol binding protein like 7",TRUE
+"208163_s_at",0.993819570187391,0.970718423536751,0.037124209382048,-5.93901222926584,0.0365285853567734,"OSBPL7","oxysterol binding protein like 7",TRUE
+"212582_at",0.714795139167042,0.190356008103835,1.35092179755644,-5.0878617567603,0.456765084370616,"OSBPL8","oxysterol binding protein like 8",TRUE
+"228985_at",0.801455134542848,0.338091588673205,0.979119413280049,-5.48323350662677,0.719603462642749,"OSBPL8","oxysterol binding protein like 8",TRUE
+"212585_at",0.899808883319249,0.592577465653089,0.542960817594612,-5.79710529044748,0.203972228465167,"OSBPL8","oxysterol binding protein like 8",TRUE
+"228986_at",0.932249295738588,0.701173086378829,0.388748137525519,-5.86634287342956,0.12376189907615,"OSBPL8","oxysterol binding protein like 8",TRUE
+"218047_at",0.773657212801073,0.285153668305141,1.0952888798052,-5.37167896199622,0.580861286544117,"OSBPL9","oxysterol binding protein like 9",TRUE
+"1554503_a_at",0.903383391791809,0.603544371232795,0.526833454192175,-5.80539414477633,0.466852971669707,"OSCAR","osteoclast associated, immunoglobulin-like receptor",TRUE
+"227359_at",0.929126743655924,0.68830576213733,-0.406457458642132,-5.85953569962307,-0.155320389758411,"OSCP1","organic solute carrier partner 1",TRUE
+"221954_at",0.983051865094694,0.917656920690576,0.104571201221825,-5.93435878224937,0.0465339337506769,"OSER1","oxidative stress responsive serine rich 1",TRUE
+"209020_at",0.999639752011996,0.999219235975485,-0.000989642593208367,-5.93968300372316,-0.000492544767212166,"OSER1","oxidative stress responsive serine rich 1",TRUE
+"1569746_s_at",0.835952408568777,0.416236833842982,0.8284754662955,-5.61079493364699,0.668882644133916,"OSER1-AS1","OSER1 antisense RNA 1 (head to head)",TRUE
+"1569745_at",0.909732972837956,0.624541877192002,0.496341338341206,-5.82040030552346,0.208607785749161,"OSER1-AS1","OSER1 antisense RNA 1 (head to head)",TRUE
+"1558906_a_at",0.958513463150671,0.811961775428097,0.240751107910732,-5.91149213267689,0.137129313756978,"OSER1-AS1","OSER1 antisense RNA 1 (head to head)",TRUE
+"209450_at",0.776954388941225,0.295434163066079,1.07159939995353,-5.39533785948563,0.454281775368054,"OSGEP","O-sialoglycoprotein endopeptidase",TRUE
+"242930_at",0.877861946695164,0.529381736940195,0.638988038467675,-5.7427458912791,0.285312910007793,"OSGEP","O-sialoglycoprotein endopeptidase",TRUE
+"220631_at",0.927612926191354,0.682687050137456,0.414231839309749,-5.85645309829375,0.146824234587408,"OSGEPL1","O-sialoglycoprotein endopeptidase-like 1",TRUE
+"230032_at",0.952697366942815,0.783542969996712,0.278062130493259,-5.90209447465877,0.111210793707034,"OSGEPL1","O-sialoglycoprotein endopeptidase-like 1",TRUE
+"219475_at",0.259884954108204,0.00385014746826968,-3.22731252315147,-1.84230644853646,-2.13215621078733,"OSGIN1","oxidative stress induced growth inhibitor 1",TRUE
+"204024_at",0.756313947022433,0.251359920833917,-1.17783271062083,-5.28567170551009,-0.611608692271995,"OSGIN2","oxidative stress induced growth inhibitor family member 2",TRUE
+"1554414_a_at",0.78969417320323,0.317614573898516,-1.02242388902195,-5.44296717857328,-0.649343404090336,"OSGIN2","oxidative stress induced growth inhibitor family member 2",TRUE
+"41553_at",0.925091998149497,0.675827499964503,-0.423758501097138,-5.8525973976629,-0.221576954965811,"OSGIN2","oxidative stress induced growth inhibitor family member 2",TRUE
+"214161_at",0.945819521856653,0.755306300197625,-0.315537682090893,-5.89130552311261,-0.302645156309103,"OSGIN2","oxidative stress induced growth inhibitor family member 2",TRUE
+"214637_at",0.885312914741353,0.546693489470836,0.612113576932041,-5.75881863481508,0.23276307923657,"OSM","oncostatin M",TRUE
+"230170_at",0.964970817135779,0.837525837336282,-0.207485571946886,-5.91873701118023,-0.0950905444273342,"OSM","oncostatin M",TRUE
+"226621_at",0.597654932724127,0.074557995322782,1.87136366479066,-4.3643129653739,1.66454432067315,"OSMR","oncostatin M receptor",TRUE
+"1554008_at",0.606138724709726,0.0797703244189999,1.83628794310158,-4.41857692687351,1.82671930753681,"OSMR","oncostatin M receptor",TRUE
+"205729_at",0.615821255316333,0.086655551053541,1.79288592460036,-4.48470111154106,1.6799691848914,"OSMR","oncostatin M receptor",TRUE
+"228399_at",0.724623760403195,0.201933380256375,1.31507465362393,-5.13071971155362,1.57172181215912,"OSR1","odd-skipped related transciption factor 1",TRUE
+"213568_at",0.885029460971826,0.546082222607091,0.613054687094877,-5.75826702984063,0.527490597965892,"OSR2","odd-skipped related transciption factor 2",TRUE
+"224637_at",0.818999571709518,0.373002150456231,0.909252046187158,-5.54483717477202,0.296442875098471,"OST4","oligosaccharyltransferase complex subunit 4, non-catalytic",TRUE
+"223001_at",0.955337239053323,0.79551367631298,0.262299742197482,-5.90622842270546,0.0705848348869278,"OSTC","oligosaccharyltransferase complex non-catalytic subunit",TRUE
+"1553931_at",0.704148059811236,0.176099470918772,1.397504984384,-5.03073241922252,0.798971836579885,"OSTCP1","oligosaccharyltransferase complex subunit pseudogene 1",TRUE
+"204479_at",0.710657275720264,0.183580994341989,1.37270158048656,-5.06135161930518,0.551696210284028,"OSTF1","osteoclast stimulating factor 1",TRUE
+"218196_at",0.822850703882235,0.388416766714115,-0.879788370824624,-5.56955535150244,-0.417726226113285,"OSTM1","osteopetrosis associated transmembrane protein 1",TRUE
+"235197_s_at",0.931582451098271,0.698065792421167,-0.393012920333836,-5.8647308617062,-0.165630222393471,"OSTM1","osteopetrosis associated transmembrane protein 1",TRUE
+"235198_at",0.986342822130003,0.935114676070092,-0.0823412786461875,-5.93638169023462,-0.0383969735484833,"OSTM1","osteopetrosis associated transmembrane protein 1",TRUE
+"243287_s_at",0.994634231353802,0.975095704155673,0.0315724424040144,-5.9391979785713,0.0156445697551808,"OSTM1","osteopetrosis associated transmembrane protein 1",TRUE
+"237357_at",0.963379172403332,0.832995704706475,-0.213361938055361,-5.91753504376147,-0.150042276706629,"OSTM1-AS1","OSTM1 antisense RNA 1",TRUE
+"207200_at",0.55679801038721,0.0520488528964284,2.05315979944116,-4.07179517053604,1.12369774667482,"OTC","ornithine carbamoyltransferase",TRUE
+"1555251_a_at",0.899808883319249,0.592250895716065,-0.543443273747598,-5.79685358286901,-0.286003206957614,"OTOF","otoferlin",TRUE
+"220492_s_at",0.909052380289506,0.622772317816075,0.498892332072656,-5.81917832767338,0.14519454531846,"OTOF","otoferlin",TRUE
+"1553746_a_at",0.995449549647697,0.97875403548168,0.0269333165406862,-5.93933016960655,0.0267893195506672,"OTOGL","otogelin like",TRUE
+"234271_at",0.679041081350052,0.146549690169373,1.50459947657108,-4.89339275528982,0.641365699221699,"OTOP2","otopetrin 2",TRUE
+"234551_at",0.830635993561085,0.403538105759758,0.85161609867658,-5.59248292975055,0.596707685839262,"OTOP2","otopetrin 2",TRUE
+"221209_s_at",0.870808709484996,0.510307878763711,-0.669157757670151,-5.72391229728285,-0.394760981008888,"OTOR","otoraplin",TRUE
+"242883_at",0.727286289873957,0.207616669856909,1.29806164615032,-5.15071948160898,0.61911267388833,"OTOS","otospiralin",TRUE
+"223835_x_at",0.794426378358553,0.326261797977677,1.00390725796553,-5.46037814669501,0.337851888083006,"OTP","orthopedia homeobox",TRUE
+"231488_at",0.981712176828357,0.912799303766313,0.110765793028329,-5.93370943980132,0.0620377052008605,"OTP","orthopedia homeobox",TRUE
+"1555682_at",0.23844580864332,0.00312258251465235,3.31556920431912,-1.65868898855515,1.66824493244335,"OTUB2","OTU deubiquitinase, ubiquitin aldehyde binding 2",TRUE
+"222878_s_at",0.89967769475675,0.591239663923085,0.544938039524163,-5.79607235264293,0.448504479209269,"OTUB2","OTU deubiquitinase, ubiquitin aldehyde binding 2",TRUE
+"219369_s_at",0.97928472590149,0.899901851256422,0.127235288728269,-5.93180157880192,0.0783778834455369,"OTUB2","OTU deubiquitinase, ubiquitin aldehyde binding 2",TRUE
+"226140_s_at",0.315533063224077,0.00680408745388544,2.98433333416724,-2.33959789964508,1.44307042835633,"OTUD1","OTU deubiquitinase 1",TRUE
+"231035_s_at",0.329541287798136,0.00787162179907391,2.92129474818593,-2.46632722871602,1.48952377858836,"OTUD1","OTU deubiquitinase 1",TRUE
+"238998_x_at",0.774230543658252,0.286498882056377,1.09215446997018,-5.37483579497376,0.729863820812188,"OTUD1","OTU deubiquitinase 1",TRUE
+"213216_at",0.921199576190399,0.664173521599003,-0.440036207092433,-5.84581007746101,-0.163324180610468,"OTUD3","OTU deubiquitinase 3",TRUE
+"238848_at",0.692948460442636,0.162301598555889,1.4455452405235,-4.9701456730977,0.379850466886119,"OTUD4","OTU deubiquitinase 4",TRUE
+"203479_s_at",0.749197955891564,0.242315216180249,1.20131057633627,-5.26020959278058,0.541313635047902,"OTUD4","OTU deubiquitinase 4",TRUE
+"220669_at",0.830635993561085,0.404460537370707,0.849919681059472,-5.59384135523353,0.281188668731246,"OTUD4","OTU deubiquitinase 4",TRUE
+"203480_s_at",0.92247975200053,0.668704760931027,0.433693074954571,-5.8484848495787,0.141920936473593,"OTUD4","OTU deubiquitinase 4",TRUE
+"1555426_a_at",0.865885012497452,0.496372833360331,0.69159897673916,-5.70936395248226,0.229614185877866,"OTUD5","OTU deubiquitinase 5",TRUE
+"233933_s_at",0.8877101263145,0.552720493227596,0.602863945402487,-5.76419652997115,0.159021660632973,"OTUD5","OTU deubiquitinase 5",TRUE
+"224745_x_at",0.998038817582822,0.991048705306645,-0.0113462958786814,-5.93962077720082,-0.0030565758664558,"OTUD5","OTU deubiquitinase 5",TRUE
+"222825_at",0.896229101808264,0.579904168000833,-0.561781046290096,-5.78712545607183,-0.303492561157761,"OTUD6B","OTU domain containing 6B",TRUE
+"227765_at",0.517348414110187,0.0365539036329922,-2.22523628320812,-3.77877607434894,-1.31337215075911,"OTUD6B-AS1","OTUD6B antisense RNA 1 (head to head)",TRUE
+"226341_at",0.725178543391177,0.203613250415175,-1.31000759413126,-5.13669937305147,-0.69648147555128,"OTUD6B-AS1","OTUD6B antisense RNA 1 (head to head)",TRUE
+"1553351_at",0.248692078473507,0.00343432836266796,-3.2755364169327,-1.74215164015958,-1.55803539564358,"OTUD7A","OTU deubiquitinase 7A",TRUE
+"232562_at",0.880814827834223,0.536426271114441,-0.627996108998239,-5.74940015432554,-0.359918554363623,"OTUD7A","OTU deubiquitinase 7A",TRUE
+"1560399_a_at",0.915425400931623,0.643552009796229,-0.46914155663728,-5.83304875588147,-0.361602886242336,"OTUD7A","OTU deubiquitinase 7A",TRUE
+"227436_at",0.739367922105944,0.227371768042398,-1.24158898458422,-5.21551318033901,-0.408228826925191,"OTUD7B","OTU deubiquitinase 7B",TRUE
+"238573_at",0.76923099885665,0.275169719697522,-1.11889340610027,-5.34764755188485,-0.618583554278858,"OTUD7B","OTU deubiquitinase 7B",TRUE
+"229488_at",0.828607509614823,0.398990160054247,-0.860016638627167,-5.58571891622045,-0.275480008056988,"OTUD7B","OTU deubiquitinase 7B",TRUE
+"1555139_a_at",0.87927534655779,0.53316525358283,0.633074669782492,-5.74633951345045,0.492173050293951,"OTUD7B","OTU deubiquitinase 7B",TRUE
+"220031_at",0.919832926184047,0.658916294103708,0.447418705402696,-5.84264903559165,0.280786713051161,"OTUD7B","OTU deubiquitinase 7B",TRUE
+"238994_at",0.947778780715578,0.762256947349279,0.306272058318077,-5.89409869555344,0.114233431374677,"OTUD7B","OTU deubiquitinase 7B",TRUE
+"228382_at",0.255831879596455,0.00373399109911641,3.24025416990966,-1.81547098259768,1.05659283442878,"OTULIN","OTU deubiquitinase with linear linkage specificity",TRUE
+"229268_at",0.639656559005154,0.110054574786974,1.66468737890558,-4.67317900636519,0.520595007139523,"OTULIN","OTU deubiquitinase with linear linkage specificity",TRUE
+"240834_at",0.769847953580141,0.277930723218232,1.11230428011875,-5.35440157687144,0.524766245017445,"OTULIN","OTU deubiquitinase with linear linkage specificity",TRUE
+"238839_at",0.662165263659621,0.130071420790203,1.5722206190732,-4.80249877205823,0.479161908528378,"OTX1","orthodenticle homeobox 1",TRUE
+"231731_at",0.949150620071833,0.770500249131564,0.295318539490159,-5.89729427061628,0.110612462556617,"OTX2","orthodenticle homeobox 2",TRUE
+"242128_at",0.996168756168935,0.980931865333484,0.0241719072531222,-5.93939890297437,0.0223211488844552,"OTX2","orthodenticle homeobox 2",TRUE
+"1561319_at",0.51470556386048,0.0353288593266104,2.24153206580169,-3.75027368390819,1.56633005747495,"OTX2-AS1","OTX2 antisense RNA 1 (head to head)",TRUE
+"1557060_at",0.874305976196739,0.520242993694484,0.65336695542136,-5.73387375060404,0.469703462006686,"OVAAL","ovarian adenocarcinoma amplified long non-coding RNA",TRUE
+"222041_at",0.596382916302699,0.072793104939666,1.88372578625521,-4.34501518078458,0.624033805387017,"OVCA2///DPH1","ovarian tumor suppressor candidate 2///diphthamide biosynthesis 1",TRUE
+"202632_at",0.938984663220785,0.727281360096874,0.35319380228162,-5.87910634641448,0.099528294846202,"OVCA2///DPH1","ovarian tumor suppressor candidate 2///diphthamide biosynthesis 1",TRUE
+"240818_at",0.490107603095446,0.0292764779462227,2.33050941648851,-3.59248474764079,1.09612250656638,"OVCH1-AS1","OVCH1 antisense RNA 1",TRUE
+"205432_at",0.909052380289506,0.622276487557398,-0.499607721616662,-5.81883454350825,-0.307808922322212,"OVGP1","oviductal glycoprotein 1",TRUE
+"229396_at",0.819018525257656,0.374290924293168,0.906758311191173,-5.54695841698568,0.51791855658154,"OVOL1","ovo like transcriptional repressor 1",TRUE
+"206604_at",0.988713664405312,0.945502053452958,-0.0691353372312603,-5.93735573573197,-0.0635212934481233,"OVOL1","ovo like transcriptional repressor 1",TRUE
+"230617_at",0.94214388523134,0.739721195620178,-0.336417831933076,-5.88470899764941,-0.197466527904998,"OVOL1-AS1","OVOL1 antisense RNA 1",TRUE
+"211778_s_at",0.796392685734302,0.329015418113698,0.998082603775603,-5.46579536085993,0.9138099577393,"OVOL2","ovo like zinc finger 2",TRUE
+"206048_at",0.908667507590078,0.620267196672629,0.502509461469738,-5.8174351667414,0.35281426934896,"OVOL2","ovo like zinc finger 2",TRUE
+"216311_at",0.950926616697165,0.775910497619482,-0.288149601311771,-5.8993232546661,-0.105912954400474,"OVOL3","ovo like zinc finger 3",TRUE
+"208717_at",0.807084045192774,0.348339562438169,-0.958123246537049,-5.50218520542426,-0.39362324242725,"OXA1L","OXA1L, mitochondrial inner membrane protein",TRUE
+"202780_at",0.667600335207197,0.133989538344399,1.5555279881736,-4.82523004652298,1.14835782839768,"OXCT1","3-oxoacid CoA-transferase 1",TRUE
+"233301_at",0.61760967235709,0.0880975763390238,1.7841753371976,-4.49783375605504,0.526189146260002,"OXCT2","3-oxoacid CoA-transferase 2",TRUE
+"220256_s_at",0.759156678237018,0.256737032295622,1.16417250378518,-5.30028433877537,0.860253804951609,"OXCT2","3-oxoacid CoA-transferase 2",TRUE
+"1553222_at",0.943294768503521,0.744975351821314,0.329361987541322,-5.88698488308222,0.100115190135657,"OXER1","oxoeicosanoid receptor 1",TRUE
+"1553319_at",0.990810941805126,0.956418880864828,0.0552698034089852,-5.9381957336048,0.0616690116321825,"OXGR1","oxoglutarate receptor 1",TRUE
+"221797_at",0.607377668936197,0.0809473203122774,-1.82864427827595,-4.43030481648787,-1.03155874246236,"OXLD1","oxidoreductase like domain containing 1",TRUE
+"50374_at",0.615821255316333,0.086539434012584,-1.79359275761965,-4.48363340299169,-0.839264610051369,"OXLD1","oxidoreductase like domain containing 1",TRUE
+"227686_at",0.605913415325856,0.0794586042594675,-1.8383287151318,-4.41543979162549,-0.672560818350636,"OXNAD1","oxidoreductase NAD binding domain containing 1",TRUE
+"235205_at",0.756795789115566,0.252168724015921,1.17576418948137,-5.28789402801165,1.56764894285743,"OXR1","oxidation resistance 1",TRUE
+"238409_x_at",0.945116582640896,0.752549909524543,0.319219887261396,-5.8901726089004,0.25500947289891,"OXR1","oxidation resistance 1",TRUE
+"222553_x_at",0.963458159500472,0.833290006375527,-0.212979946641851,-5.91761419296631,-0.0972596871185818,"OXR1","oxidation resistance 1",TRUE
+"218197_s_at",0.992816117752561,0.965998252373288,0.0431122148353098,-5.93877823504467,0.0220630655383527,"OXR1","oxidation resistance 1",TRUE
+"223879_s_at",0.998000510878671,0.990516647879855,0.0120207431596554,-5.93961310121634,0.00675008920766906,"OXR1","oxidation resistance 1",TRUE
+"219133_at",0.895100616091923,0.572651567449097,-0.572643914769799,-5.78121506986397,-0.180427184487005,"OXSM","3-oxoacyl-ACP synthase, mitochondrial",TRUE
+"202696_at",0.279325273101419,0.00452893955490041,3.15850900398168,-1.98442391984148,1.10842652839867,"OXSR1","oxidative stress responsive 1",TRUE
+"207576_x_at",0.786455312223125,0.312019335302755,1.03459399083154,-5.43136723961577,0.516983766765182,"OXT","oxytocin/neurophysin I prepropeptide",TRUE
+"206825_at",0.721297082581089,0.197496939507762,1.3286162994936,-5.11464359660093,1.27032671209928,"OXTR","oxytocin receptor",TRUE
+"210401_at",0.67842163564685,0.14578251327188,-1.50760533617728,-4.88941994258503,-0.992454004948105,"P2RX1","purinergic receptor P2X 1",TRUE
+"221372_s_at",0.718287472615499,0.19415766909528,-1.33896673194664,-5.10226253933265,-1.20235216998017,"P2RX2","purinergic receptor P2X 2",TRUE
+"221356_x_at",0.863865128741987,0.489914295864542,-0.702121315159582,-5.70238467106411,-0.580529654370046,"P2RX2","purinergic receptor P2X 2",TRUE
+"224557_x_at",0.91671872326659,0.647893832674548,-0.462980048855722,-5.83581709084572,-0.420699425815712,"P2RX2","purinergic receptor P2X 2",TRUE
+"224069_x_at",0.960614707352139,0.821014718991684,0.228941050408419,-5.91418674760399,0.155766624613001,"P2RX2","purinergic receptor P2X 2",TRUE
+"208338_at",0.585036027492332,0.0654056810422404,1.93850174128328,-4.25844321451308,1.11807915899531,"P2RX3","purinergic receptor P2X 3",TRUE
+"204088_at",0.979588787486838,0.902287711275891,0.124186068034264,-5.93217469623468,0.0702549916337833,"P2RX4","purinergic receptor P2X 4",TRUE
+"210448_s_at",0.562643595171948,0.0552818632676241,2.02319465295681,-4.12126537030201,1.96223460917138,"P2RX5","purinergic receptor P2X 5",TRUE
+"209154_at",0.825648186672984,0.393290925902354,0.870631202632177,-5.57708385881362,0.371044979297546,"P2RX5-TAX1BP3///TAX1BP3","P2RX5-TAX1BP3 readthrough (NMD candidate)///Tax1 binding protein 3",TRUE
+"215464_s_at",0.878788356961452,0.532086968438001,0.634757630084342,-5.7453200302711,0.298712168488576,"P2RX5-TAX1BP3///TAX1BP3///P2RX5","P2RX5-TAX1BP3 readthrough (NMD candidate)///Tax1 binding protein 3///purinergic receptor P2X 5",TRUE
+"211147_s_at",0.744931128252932,0.236616573502206,-1.21644291547339,-5.24356699415864,-0.5040650210414,"P2RX6","purinergic receptor P2X 6",TRUE
+"206880_at",0.983099438828965,0.917739284093834,0.104466205550185,-5.93436946669621,0.0582503411884359,"P2RX6","purinergic receptor P2X 6",TRUE
+"207091_at",0.594972224548427,0.0716748797310167,1.89169465644747,-4.33252814464498,1.20948255806611,"P2RX7","purinergic receptor P2X 7",TRUE
+"230741_at",0.88113080359582,0.5373298837196,0.6265918071083,-5.75024228191264,0.574602176042665,"P2RX7","purinergic receptor P2X 7",TRUE
+"231925_at",0.554642754132296,0.0511263795188515,2.0620144687324,-4.05708546379016,2.41009393986009,"P2RY1","purinergic receptor P2Y1",TRUE
+"207455_at",0.588653540532996,0.0672524406679628,1.92431786110869,-4.28102548120651,0.993176430999721,"P2RY1","purinergic receptor P2Y1",TRUE
+"236280_at",0.791211889207316,0.321650967744143,-1.01373739902032,-5.45117084609107,-0.998025401824419,"P2RY10","purinergic receptor P2Y10",TRUE
+"1553856_s_at",0.940227139261806,0.732178967922207,-0.346576977338622,-5.88134834093519,-0.167922697142355,"P2RY10","purinergic receptor P2Y10",TRUE
+"214615_at",0.958419239985859,0.811711513550502,0.241078077978755,-5.91141561303577,0.210252937894613,"P2RY10","purinergic receptor P2Y10",TRUE
+"235885_at",0.624331975868069,0.0958393831451432,1.73940531747839,-4.56459074896154,1.62673807413787,"P2RY12","purinergic receptor P2Y12",TRUE
+"224102_at",0.8920930097751,0.563486397059293,0.586471874886984,-5.77353283001532,0.391137595617555,"P2RY12","purinergic receptor P2Y12",TRUE
+"220005_at",0.975159323713639,0.878922816673032,-0.154103958654367,-5.92812330600256,-0.0727835445352989,"P2RY13","purinergic receptor P2Y13",TRUE
+"206637_at",0.736559969329597,0.222079398160007,1.25633645078514,-5.19883066714299,0.859650998244281,"P2RY14","purinergic receptor P2Y14",TRUE
+"206277_at",0.936143408699214,0.714791534137644,-0.370141776439122,-5.87317284698568,-0.425710053371822,"P2RY2","purinergic receptor P2Y2",TRUE
+"221466_at",0.881855248501214,0.53877444391284,0.624349451430082,-5.75158320771497,0.201528703583016,"P2RY4","pyrimidinergic receptor P2Y4",TRUE
+"208373_s_at",0.767727587789514,0.27017538200984,1.13093602911822,-5.33521236995013,1.11611937415489,"P2RY6","pyrimidinergic receptor P2Y6",TRUE
+"229686_at",0.769847953580141,0.277468359724378,1.11340437532675,-5.35327640927585,0.690495011357576,"P2RY8","purinergic receptor P2Y8",TRUE
+"220750_s_at",0.949495693037756,0.771794532488899,-0.293602104132996,-5.89778456599616,-0.141950384955091,"P3H1","prolyl 3-hydroxylase 1",TRUE
+"218717_s_at",0.540483367247649,0.0447022778275856,2.12798226006724,-3.9462136584416,4.61082045181037,"P3H2","prolyl 3-hydroxylase 2",TRUE
+"230813_at",0.969577323811311,0.854789517055347,0.18515805855372,-5.92299903077107,0.0684922535103532,"P3H2","prolyl 3-hydroxylase 2",TRUE
+"204854_at",0.67182900253525,0.137843214457072,1.53949892310428,-4.84687749319593,1.61784798147008,"P3H3","prolyl 3-hydroxylase 3",TRUE
+"204078_at",0.890302070370912,0.558671673202664,0.593782430282213,-5.769399743442,0.459203463724187,"P3H4","prolyl 3-hydroxylase family member 4 (non-enzymatic)",TRUE
+"243335_at",0.808233282592165,0.350345291219649,0.954063288130588,-5.50580649838171,0.955871558675873,"P4HA1","prolyl 4-hydroxylase subunit alpha 1",TRUE
+"207543_s_at",0.969450447163359,0.854581739116541,-0.185426187529416,-5.92295071401175,-0.0860679217361984,"P4HA1","prolyl 4-hydroxylase subunit alpha 1",TRUE
+"1568611_at",0.683019114815084,0.152085794810213,1.48328128561275,-4.92138605774147,0.704378833384125,"P4HA2","prolyl 4-hydroxylase subunit alpha 2",TRUE
+"228703_at",0.627092759817312,0.0988235864071974,1.72297253743131,-4.58877875612852,0.996561473034045,"P4HA3","prolyl 4-hydroxylase subunit alpha 3",TRUE
+"1560715_at",0.997033004876606,0.984704775562757,-0.0193884370577547,-5.93950038977988,-0.00964726029624119,"P4HA3","prolyl 4-hydroxylase subunit alpha 3",TRUE
+"200656_s_at",0.623792624906269,0.0953914977017159,-1.74190926701841,-4.56089013410985,-0.585416783046011,"P4HB","prolyl 4-hydroxylase subunit beta",TRUE
+"200654_at",0.662015916975184,0.129931707093889,-1.57282350330068,-4.80167422661395,-0.464660754735419,"P4HB","prolyl 4-hydroxylase subunit beta",TRUE
+"1564494_s_at",0.819018525257656,0.37410370645815,-0.907120218607697,-5.54665090185937,-0.416571274783189,"P4HB","prolyl 4-hydroxylase subunit beta",TRUE
+"222125_s_at",0.7994347047598,0.334533892491972,-0.986510324108849,-5.47647317017012,-0.802965572379739,"P4HTM","prolyl 4-hydroxylase, transmembrane",TRUE
+"208676_s_at",0.871406341794058,0.512133515882368,-0.666243370015718,-5.7257679605276,-0.26051093228603,"PA2G4","proliferation-associated 2G4",TRUE
+"214794_at",0.937113154905832,0.720142322217245,-0.362867831738531,-5.87575309136646,-0.123497860734371,"PA2G4","proliferation-associated 2G4",TRUE
+"1568702_a_at",0.700061364939874,0.17167945672696,1.41255547452559,-5.0119321960923,1.10587151294888,"PAAF1","proteasomal ATPase associated factor 1",TRUE
+"218957_s_at",0.914221041533407,0.639080992476354,-0.475505728811598,-5.8301517540541,-0.296154842578906,"PAAF1","proteasomal ATPase associated factor 1",TRUE
+"215157_x_at",0.819018525257656,0.373614087265483,0.908067259126077,-5.54584565911159,0.27284016900323,"PABPC1","poly(A) binding protein cytoplasmic 1",TRUE
+"1560770_at",0.973071267819624,0.87073628517007,0.164619236844358,-5.92649292992009,0.137223035445474,"PABPC1","poly(A) binding protein cytoplasmic 1",TRUE
+"233104_at",0.893334037681196,0.56795947844236,-0.579708853595889,-5.77731225314915,-0.348023424859772,"PABPC1L","poly(A) binding protein cytoplasmic 1 like",TRUE
+"226670_s_at",0.896665210168928,0.581491693771553,0.55941239658825,-5.78839963854562,0.691943536112822,"PABPC1L","poly(A) binding protein cytoplasmic 1 like",TRUE
+"231838_at",0.89767014756104,0.584741074133264,-0.55457424382739,-5.79098602195177,-0.324038028092287,"PABPC1L","poly(A) binding protein cytoplasmic 1 like",TRUE
+"1557203_at",0.823074246722209,0.389234479174492,-0.878246929609347,-5.57082775561706,-0.310402907774088,"PABPC1L2B///PABPC1L2A","poly(A) binding protein cytoplasmic 1 like 2B///poly(A) binding protein cytoplasmic 1 like 2A",TRUE
+"208113_x_at",0.986342822130003,0.933456659340005,0.0844505169417546,-5.93621039708212,0.0273201849972136,"PABPC3","poly(A) binding protein cytoplasmic 3",TRUE
+"238865_at",0.777463110382572,0.296365046151381,1.06948374050853,-5.39742830506162,1.43693661336705,"PABPC4L","poly(A) binding protein cytoplasmic 4 like",TRUE
+"233136_at",0.824145372094001,0.391595292576681,-0.873808420194311,-5.57448001626413,-1.1805231504779,"PABPC5","poly(A) binding protein cytoplasmic 5",TRUE
+"213046_at",0.66120440880682,0.128915208008792,-1.57722610569721,-4.79564541907483,-0.526680786398787,"PABPN1","poly(A) binding protein nuclear 1",TRUE
+"234096_at",0.474981499638426,0.0261578518554714,-2.38318812652494,-3.49740562635811,-2.05119318895379,"PACRG","PARK2 coregulated",TRUE
+"214204_at",0.798860829144003,0.33336641385916,-0.988947480807739,-5.47423380259941,-0.705492873315437,"PACRG","PARK2 coregulated",TRUE
+"215472_at",0.908667507590078,0.620199508745905,0.502607289773711,-5.81738785078977,0.2671797928464,"PACRG","PARK2 coregulated",TRUE
+"1561373_at",0.639705117673934,0.110201928973901,-1.66395681266849,-4.67422295757619,-0.96493412627555,"PACRG-AS1","PACRG antisense RNA 1",TRUE
+"1564685_a_at",0.904092974845832,0.606258821739737,0.522863627131294,-5.80739717716737,0.464829565857297,"PACRG-AS2","PACRG antisense RNA 2",TRUE
+"1562864_at",0.937257436560633,0.721669598250744,0.360795300226295,-5.87647901321662,0.219429494648647,"PACRG-AS2","PACRG antisense RNA 2",TRUE
+"243122_at",0.862639573412331,0.486070931206392,0.708420834584064,-5.69815822977589,0.366918189196961,"PACRG-AS3","PACRG antisense RNA 3",TRUE
+"235259_at",0.708894565317004,0.181287848310503,1.3802173704596,-5.05212158549531,1.19295915062118,"PACRGL","PARK2 coregulated like",TRUE
+"235260_s_at",0.81836001261482,0.371601533225031,0.911968670674003,-5.54252021758385,0.283758977493054,"PACRGL","PARK2 coregulated like",TRUE
+"235517_at",0.908709061737317,0.620852727464627,0.501663410224243,-5.81784399557101,0.193317584488867,"PACRGL","PARK2 coregulated like",TRUE
+"235554_x_at",0.948684674264832,0.766735251557198,0.300316728290155,-5.89585041073719,0.111966603144309,"PACRGL","PARK2 coregulated like",TRUE
+"224658_x_at",0.951810226174863,0.77905904146747,0.28398468315844,-5.90047931252523,0.0954274357043889,"PACS1","phosphofurin acidic cluster sorting protein 1",TRUE
+"220557_s_at",0.990781579965982,0.95317990134816,0.059382368541309,-5.9379661126824,0.0334650966011143,"PACS1","phosphofurin acidic cluster sorting protein 1",TRUE
+"212778_at",0.797433634184053,0.330783116987353,-0.994361222410844,-5.46924144441904,-0.435054655766146,"PACS2","phosphofurin acidic cluster sorting protein 2",TRUE
+"1555824_a_at",0.812302873476553,0.36065470003242,-0.933439416697592,-5.5239842594414,-0.434024462401622,"PACS2","phosphofurin acidic cluster sorting protein 2",TRUE
+"34406_at",0.885029460971826,0.545809174143932,-0.613475254481924,-5.75802026201975,-0.249728221742139,"PACS2","phosphofurin acidic cluster sorting protein 2",TRUE
+"1555823_at",0.930281902770188,0.691717978513383,0.401748553980452,-5.8613748643454,0.114348356975801,"PACS2","phosphofurin acidic cluster sorting protein 2",TRUE
+"224360_s_at",0.768285407497397,0.271453818052761,1.12783798896235,-5.33842264051245,0.503684123019314,"PACSIN1","protein kinase C and casein kinase substrate in neurons 1",TRUE
+"227053_at",0.974536463688956,0.875539278651553,-0.158447754595729,-5.92746281713529,-0.175924271049817,"PACSIN1","protein kinase C and casein kinase substrate in neurons 1",TRUE
+"233705_at",0.738061563377262,0.224973923267177,1.24823786870938,-5.20801282866573,0.580185567844946,"PACSIN2","protein kinase C and casein kinase substrate in neurons 2",TRUE
+"201651_s_at",0.894963835772043,0.572318528649908,-0.573144402048804,-5.7809401159903,-0.256165870205784,"PACSIN2","protein kinase C and casein kinase substrate in neurons 2",TRUE
+"1554691_a_at",0.93423034725099,0.708936217450073,-0.378124979334321,-5.87028285155857,-0.149581323328482,"PACSIN2","protein kinase C and casein kinase substrate in neurons 2",TRUE
+"218744_s_at",0.839519981963042,0.428175303582621,0.807123131865822,-5.62727277583394,0.343076265369421,"PACSIN3","protein kinase C and casein kinase substrate in neurons 3",TRUE
+"223739_at",0.406142422607459,0.0153309852774851,2.62731413456077,-3.04209132162219,2.87885619098317,"PADI1","peptidyl arginine deiminase 1",TRUE
+"220962_s_at",0.640337040581689,0.111125854698476,1.65939478698349,-4.68073402456404,0.608453955126988,"PADI1","peptidyl arginine deiminase 1",TRUE
+"1554385_a_at",0.80818658267298,0.350022045932147,0.954716527347008,-5.50522478967464,0.418770683244313,"PADI2","peptidyl arginine deiminase 2",TRUE
+"209791_at",0.820293495506061,0.379382928593722,0.896960520316578,-5.55524056977314,0.865550000020239,"PADI2","peptidyl arginine deiminase 2",TRUE
+"1554384_at",0.940031619815611,0.730566795577505,0.348753318175561,-5.88061555079743,0.254925895331844,"PADI2","peptidyl arginine deiminase 2",TRUE
+"220779_at",0.83030603167465,0.402417947915006,0.853679489677766,-5.59082724319637,1.07158499731232,"PADI3","peptidyl arginine deiminase 3",TRUE
+"211413_s_at",0.722990310174628,0.199732838774531,1.32176216614687,-5.12279791204237,0.971147352373238,"PADI4","peptidyl arginine deiminase 4",TRUE
+"211412_at",0.948429371744093,0.76556022114577,-0.301878223613861,-5.89539440643549,-0.266847626572984,"PADI4","peptidyl arginine deiminase 4",TRUE
+"220001_at",0.980009054680439,0.905195382243079,-0.120471579659439,-5.932617009373,-0.0835815552492161,"PADI4","peptidyl arginine deiminase 4",TRUE
+"206859_s_at",0.950031925101785,0.773106574419584,0.291863036589782,-5.89827843551314,0.192326927664843,"PAEP","progestagen associated endometrial protein",TRUE
+"202093_s_at",0.821187434813103,0.382442750349911,-0.891114513014221,-5.56014259967634,-0.312073502490746,"PAF1","PAF1 homolog, Paf1/RNA polymerase II complex component",TRUE
+"200815_s_at",0.296090407530139,0.00532735954954224,3.08933930456829,-2.12630313403452,0.951219933205099,"PAFAH1B1","platelet activating factor acetylhydrolase 1b regulatory subunit 1",TRUE
+"211547_s_at",0.668403802227594,0.134515808184904,1.55331675212495,-4.82822687563328,0.572758838694481,"PAFAH1B1","platelet activating factor acetylhydrolase 1b regulatory subunit 1",TRUE
+"200816_s_at",0.774011928861764,0.285736093425011,1.09393049431579,-5.37304805404086,0.388867558646666,"PAFAH1B1","platelet activating factor acetylhydrolase 1b regulatory subunit 1",TRUE
+"200813_s_at",0.813065886130395,0.36279797211866,0.929201762012645,-5.52767411800889,0.310038277261013,"PAFAH1B1","platelet activating factor acetylhydrolase 1b regulatory subunit 1",TRUE
+"210160_at",0.508488499910913,0.0335569100301468,2.26603877262429,-3.70717570969869,0.830476151117539,"PAFAH1B2","platelet activating factor acetylhydrolase 1b catalytic subunit 2",TRUE
+"224777_s_at",0.740610299769501,0.230513195354481,1.23295859266952,-5.22519735408193,0.369984495137068,"PAFAH1B2","platelet activating factor acetylhydrolase 1b catalytic subunit 2",TRUE
+"1569431_at",0.754263867282993,0.247530984374188,1.18769322679509,-5.2750311631615,0.704404898271093,"PAFAH1B2","platelet activating factor acetylhydrolase 1b catalytic subunit 2",TRUE
+"203228_at",0.327864702134751,0.00767793971696939,-2.93209820493649,-2.44468267126536,-1.06419481559421,"PAFAH1B3","platelet activating factor acetylhydrolase 1b catalytic subunit 3",TRUE
+"205233_s_at",0.908667507590078,0.620153241328748,-0.502674162209592,-5.81735550188048,-0.166504123392559,"PAFAH2","platelet activating factor acetylhydrolase 2",TRUE
+"205232_s_at",0.969882914559333,0.857119204701221,-0.182152637427438,-5.92353583827918,-0.0618931528065936,"PAFAH2","platelet activating factor acetylhydrolase 2",TRUE
+"225626_at",0.556381379241158,0.0518958214256878,-2.05461896738386,-4.06937399498588,-2.85449933312217,"PAG1","phosphoprotein membrane anchor with glycosphingolipid microdomains 1",TRUE
+"225622_at",0.757950630724418,0.2540930306957,-1.17086254851261,-5.29314648422124,-0.729425300565849,"PAG1","phosphoprotein membrane anchor with glycosphingolipid microdomains 1",TRUE
+"227354_at",0.842224301155785,0.435759465723252,-0.793750722236786,-5.63738667529147,-0.95355004776991,"PAG1","phosphoprotein membrane anchor with glycosphingolipid microdomains 1",TRUE
+"206897_at",0.594972224548427,0.0714660044741039,-1.89319522166324,-4.33017266172427,-0.957998632085449,"PAGE1","PAGE family member 1",TRUE
+"205564_at",0.614178202960275,0.0851960203904674,1.8018305334347,-4.47116728037154,1.00757863989959,"PAGE4","PAGE family member 4",TRUE
+"236152_at",0.947778780715578,0.761404537575448,-0.307406883369775,-5.89376102864876,-0.262552468472455,"PAGE5","PAGE family member 5",TRUE
+"218300_at",0.323645710780045,0.00736822485167675,-2.94992813034179,-2.40889285977118,-1.33771605695135,"PAGR1","PAXIP1 associated glutamate rich protein 1",TRUE
+"231878_at",0.486977667376024,0.0287243342896695,-2.33944729620433,-3.57643790711623,-1.20548224824416,"PAGR1","PAXIP1 associated glutamate rich protein 1",TRUE
+"214664_at",0.801892820429336,0.339544619385779,0.976116188842099,-5.48596726841461,0.502441317871201,"PAICS","phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase",TRUE
+"201013_s_at",0.872847039074404,0.51718368643541,-0.658211441565373,-5.73084191266817,-0.185733224499574,"PAICS","phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase",TRUE
+"201014_s_at",0.939290937475152,0.728226003398865,0.351916316603069,-5.87954246365276,0.134574298494481,"PAICS","phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase",TRUE
+"209063_x_at",0.8080774583842,0.349878695424402,0.955006352134415,-5.50496658433715,0.271667237851045,"PAIP1","poly(A) binding protein interacting protein 1",TRUE
+"209064_x_at",0.892746695408886,0.565806282383333,-0.582960926012785,-5.77550017111655,-0.206625646349579,"PAIP1","poly(A) binding protein interacting protein 1",TRUE
+"210283_x_at",0.904381089098038,0.607945834771873,0.520400689481284,-5.80863246983261,0.151604199819708,"PAIP1","poly(A) binding protein interacting protein 1",TRUE
+"208051_s_at",0.930558143410966,0.692804876580313,-0.400250563984514,-5.86195551310736,-0.142265823238469,"PAIP1","poly(A) binding protein interacting protein 1",TRUE
+"213754_s_at",0.938500267760216,0.726436070312873,0.354337435520669,-5.87871460016087,0.110578672691343,"PAIP1","poly(A) binding protein interacting protein 1",TRUE
+"222984_at",0.662015916975184,0.129894871768387,-1.57298254247007,-4.80145667251905,-0.502666021050871,"PAIP2","poly(A) binding protein interacting protein 2",TRUE
+"1560065_at",0.672434875127089,0.138340273461625,1.53745843732962,-4.84962045956643,0.819567800963832,"PAIP2","poly(A) binding protein interacting protein 2",TRUE
+"222983_s_at",0.673356287352323,0.139120536383079,-1.53426750713835,-4.85390415161729,-0.505722923753614,"PAIP2","poly(A) binding protein interacting protein 2",TRUE
+"221868_at",0.845442858996867,0.442398174593514,0.782162651736518,-5.64602241785729,0.617902673354975,"PAIP2B","poly(A) binding protein interacting protein 2B",TRUE
+"230100_x_at",0.73759219552868,0.224348792063279,1.24998015034892,-5.20604173583869,0.727587132210695,"PAK1","p21 (RAC1) activated kinase 1",TRUE
+"226507_at",0.774230543658252,0.289236124367444,1.08580920984955,-5.38120177245181,0.628450864775083,"PAK1","p21 (RAC1) activated kinase 1",TRUE
+"1565772_at",0.910053424070078,0.625594109623665,0.494826024322822,-5.82112327567854,0.137833863898503,"PAK1","p21 (RAC1) activated kinase 1",TRUE
+"209615_s_at",0.94895689004559,0.76905095033006,-0.297241626987707,-5.89674157929477,-0.222755150995148,"PAK1","p21 (RAC1) activated kinase 1",TRUE
+"218886_at",0.657015752622694,0.125563621148434,1.59194959769095,-4.77538778736452,0.638868174760916,"PAK1IP1","PAK1 interacting protein 1",TRUE
+"208878_s_at",0.721499527275875,0.197793245388226,1.32770450123417,-5.11573040491832,0.42410378505752,"PAK2","p21 (RAC1) activated kinase 2",TRUE
+"208876_s_at",0.820737386171629,0.381644760969867,0.892636161565141,-5.55886951376184,0.299225230774336,"PAK2","p21 (RAC1) activated kinase 2",TRUE
+"208877_at",0.868570766525613,0.504657603196106,0.678214856620799,-5.71809593239706,0.20506622715572,"PAK2","p21 (RAC1) activated kinase 2",TRUE
+"208875_s_at",0.871165715950006,0.511746834297214,0.666860171293477,-5.72537587502306,0.241835768503719,"PAK2","p21 (RAC1) activated kinase 2",TRUE
+"1559052_s_at",0.909052380289506,0.622508181390676,0.49927339824735,-5.81899526419824,0.221379546509832,"PAK2","p21 (RAC1) activated kinase 2",TRUE
+"205962_at",0.951339758531576,0.777381219611596,-0.286203475667654,-5.8998655198955,-0.189232858833012,"PAK2","p21 (RAC1) activated kinase 2",TRUE
+"236277_at",0.327689791987697,0.0075745645551209,2.93797160860794,-2.43290233197805,3.35673067107218,"PAK3","p21 (RAC1) activated kinase 3",TRUE
+"229201_at",0.603702127972549,0.0781327110344754,1.84708757078301,-4.40194717143733,1.90333550621753,"PAK3","p21 (RAC1) activated kinase 3",TRUE
+"214078_at",0.741143136625128,0.231391190529327,1.23056248730908,-5.22787569857367,1.35758092920417,"PAK3","p21 (RAC1) activated kinase 3",TRUE
+"214607_at",0.88440457468396,0.54364280994864,-0.616815996687571,-5.75605428685977,-0.333845007398086,"PAK3","p21 (RAC1) activated kinase 3",TRUE
+"33814_at",0.630603891142543,0.101546224658623,-1.70834530244863,-4.6101649662171,-0.592076781708057,"PAK4","p21 (RAC1) activated kinase 4",TRUE
+"203154_s_at",0.682125064335234,0.149658509586638,-1.49254893202876,-4.90925598256432,-0.588825473175925,"PAK4","p21 (RAC1) activated kinase 4",TRUE
+"215326_at",0.950031925101785,0.773120882134602,0.291844077268164,-5.89828380364584,0.202905068296628,"PAK4","p21 (RAC1) activated kinase 4",TRUE
+"213990_s_at",0.885029460971826,0.545654767519754,-0.61371313118899,-5.75788061566225,-0.422084892105536,"PAK5","p21 (RAC1) activated kinase 5",TRUE
+"210721_s_at",0.942684843065067,0.742943923312914,-0.332087966008604,-5.88611126756652,-0.284426503784119,"PAK5","p21 (RAC1) activated kinase 5",TRUE
+"1555310_a_at",0.638684632383754,0.109681455981027,1.66654096189338,-4.67052874308577,1.32400344133368,"PAK6","p21 (RAC1) activated kinase 6",TRUE
+"219461_at",0.680708651141727,0.148606318355131,1.4966044150187,-4.90392880996078,1.7783728159692,"PAK6","p21 (RAC1) activated kinase 6",TRUE
+"219530_at",0.85334340854827,0.46134569181774,-0.749660068606296,-5.66960423225629,-0.271354264633988,"PALB2","partner and localizer of BRCA2",TRUE
+"231887_s_at",0.925720361884622,0.678675354106688,0.419798560995033,-5.8542105611879,0.29406805596022,"PALD1","phosphatase domain containing, paladin 1",TRUE
+"200906_s_at",0.643082025527735,0.113580030027739,1.64743036755422,-4.69774520272023,1.22778231115407,"PALLD","palladin, cytoskeletal associated protein",TRUE
+"200897_s_at",0.705559553212919,0.177591326505447,1.39249309904611,-5.03695607512351,1.48959967146923,"PALLD","palladin, cytoskeletal associated protein",TRUE
+"200907_s_at",0.724568343940805,0.201739440325759,1.31566175360777,-5.13002561120849,1.31923409795326,"PALLD","palladin, cytoskeletal associated protein",TRUE
+"1557535_at",0.961561244483099,0.825970731744637,-0.222489846003412,-5.91560173251625,-0.189461124710422,"PALLD","palladin, cytoskeletal associated protein",TRUE
+"203859_s_at",0.889318152488679,0.556883138303702,-0.596506413589628,-5.76784706000963,-0.569267816100537,"PALM","paralemmin",TRUE
+"1554640_at",0.868397087637799,0.504140113942724,0.679047208479545,-5.71755765198559,0.821011615646302,"PALM2","paralemmin 2",TRUE
+"226694_at",0.592111379991983,0.0692111697546457,1.9096434457664,-4.30426794831669,2.98881353656044,"PALM2-AKAP2///AKAP2","PALM2-AKAP2 readthrough///A-kinase anchoring protein 2",TRUE
+"202759_s_at",0.623503825356688,0.0942574594204309,1.74829450810827,-4.55143548329725,2.32219618317227,"PALM2-AKAP2///AKAP2","PALM2-AKAP2 readthrough///A-kinase anchoring protein 2",TRUE
+"202760_s_at",0.643515428391208,0.11417136904644,1.64458009252762,-4.7017838782486,2.2767079563212,"PALM2-AKAP2///AKAP2","PALM2-AKAP2 readthrough///A-kinase anchoring protein 2",TRUE
+"1553502_a_at",0.767704684098492,0.269549644639026,1.13245629829057,-5.33363418285557,0.715138769346426,"PALM2-AKAP2///PALM2///AKAP2","PALM2-AKAP2 readthrough///paralemmin 2///A-kinase anchoring protein 2",TRUE
+"231018_at",0.576675680499645,0.0613325650005071,1.97107727991101,-4.20615000131527,2.21583621165909,"PALM3","paralemmin 3",TRUE
+"218736_s_at",0.734730148360473,0.219503830625438,-1.26361082863767,-5.19053959959801,-1.66937877527718,"PALMD","palmdelphin",TRUE
+"232187_at",0.774360462422895,0.290536934310789,1.08280892780783,-5.38420033287274,0.681128471891858,"PALMD","palmdelphin",TRUE
+"222725_s_at",0.79705794499562,0.33016494445836,-0.995661038424423,-5.46803911396196,-0.967485060389185,"PALMD","palmdelphin",TRUE
+"212958_x_at",0.888889248007057,0.556190037965957,0.597563246826172,-5.76724281120905,0.541286515908741,"PAM","peptidylglycine alpha-amidating monooxygenase",TRUE
+"202336_s_at",0.896345073598643,0.580447423297564,0.560970123497634,-5.78756226875236,0.59731770590157,"PAM","peptidylglycine alpha-amidating monooxygenase",TRUE
+"214620_x_at",0.94895689004559,0.767940387607204,0.298716016963885,-5.89631543383392,0.312780300156698,"PAM","peptidylglycine alpha-amidating monooxygenase",TRUE
+"218969_at",0.830635993561085,0.403403089853862,-0.851864610675442,-5.59228371892635,-0.254284264616581,"PAM16","presequence translocase associated motor 16 homolog",TRUE
+"213661_at",0.676889454558333,0.143685029896735,-1.51589002962051,-4.87843734536102,-1.01544087785002,"PAMR1","peptidase domain containing associated with muscle regeneration 1",TRUE
+"203117_s_at",0.54222392031861,0.0453911089766489,-2.1205148520052,-3.95887614364433,-0.759948494508917,"PAN2","PAN2 poly(A) specific ribonuclease subunit",TRUE
+"225563_at",0.90985106339387,0.624794003031412,0.495978146136491,-5.82057378453888,0.157806454931738,"PAN3","PAN3 poly(A) specific ribonuclease subunit",TRUE
+"243092_at",0.943512938262733,0.747264508865168,0.326293208819294,-5.8879598317651,0.168862996432032,"PAN3-AS1","PAN3 antisense RNA 1",TRUE
+"226649_at",0.998218866709129,0.99166448951391,0.0105657214677341,-5.93962910786088,0.00493650704411941,"PANK1","pantothenate kinase 1",TRUE
+"238548_at",0.463026328668682,0.0235260565348257,-2.43236724335687,-3.40757742432341,-1.35375397850905,"PANK2","pantothenate kinase 2",TRUE
+"228735_s_at",0.734042693548791,0.218427948906918,1.26666891585412,-5.18704187254161,0.691069275706226,"PANK2","pantothenate kinase 2",TRUE
+"228966_at",0.756795789115566,0.252221232992834,1.17563006832924,-5.28803800365203,0.75255391528959,"PANK2","pantothenate kinase 2",TRUE
+"218809_at",0.821581734701533,0.384186194990655,0.887797240697444,-5.56291101966198,0.433741232553176,"PANK2","pantothenate kinase 2",TRUE
+"228965_s_at",0.850622134716209,0.453420651595085,0.7631547183681,-5.6599281820485,0.438315830609134,"PANK2","pantothenate kinase 2",TRUE
+"235130_at",0.891653456393983,0.5616051360038,-0.589324474432032,-5.77192597812112,-0.340790999196011,"PANK2","pantothenate kinase 2",TRUE
+"238856_s_at",0.948764595648089,0.766948737315402,0.300033109453611,-5.89593298452161,0.149872473455836,"PANK2","pantothenate kinase 2",TRUE
+"218433_at",0.637812558837132,0.109134258234603,-1.6692689913796,-4.66662411352598,-0.629393611216619,"PANK3","pantothenate kinase 3",TRUE
+"221751_at",0.680708651141727,0.148691420586843,-1.49627553455863,-4.90436125092878,-0.509375821539619,"PANK3","pantothenate kinase 3",TRUE
+"218771_at",0.899808883319249,0.593297509974252,0.541897524569903,-5.79765926573252,0.1961421633649,"PANK4","pantothenate kinase 4",TRUE
+"204715_at",0.56559911410714,0.0565837967500245,2.01156706639108,-4.14033186105221,0.775542784558953,"PANX1","pannexin 1",TRUE
+"236372_at",0.637485146909712,0.108815348657712,1.67086423541612,-4.66433859232864,0.676623878458271,"PANX1","pannexin 1",TRUE
+"235295_at",0.715119690416591,0.190820933604462,1.34944973154602,-5.08964075959778,0.515473218376988,"PANX1","pannexin 1",TRUE
+"227107_at",0.8920930097751,0.563627853523114,0.586257579880643,-5.77365323653614,0.235276892814463,"PANX1","pannexin 1",TRUE
+"239067_s_at",0.595019326272843,0.071936090080798,1.88982349183338,-4.33546353626683,1.94959357793076,"PANX2","pannexin 2",TRUE
+"1552944_a_at",0.854763246850622,0.466617389269487,0.74076009506906,-5.67589628597396,0.376192802628846,"PANX2","pannexin 2",TRUE
+"244471_x_at",0.951810226174863,0.779185970240506,-0.283816888817282,-5.90052553730753,-0.0954193604977878,"PANX2","pannexin 2",TRUE
+"240955_at",0.930827859648584,0.693670936829575,0.399057605132915,-5.86241639836652,0.220030350662307,"PANX3","pannexin 3",TRUE
+"238334_at",0.694505490882266,0.163894317832129,-1.43983613079104,-4.9774335550089,-0.755165702535067,"PAOX","polyamine oxidase (exo-N4-amino)",TRUE
+"221941_at",0.877740599174557,0.528526914689065,0.640327239332008,-5.7419275824861,0.348435768634551,"PAOX","polyamine oxidase (exo-N4-amino)",TRUE
+"50400_at",0.929088231432081,0.687653105204455,-0.407359196906379,-5.85918109977824,-0.211547422241393,"PAOX","polyamine oxidase (exo-N4-amino)",TRUE
+"238333_s_at",0.946913677125713,0.758902872157155,0.310739771997311,-5.89276217479186,0.270278391066195,"PAOX","polyamine oxidase (exo-N4-amino)",TRUE
+"225761_at",0.630603891142543,0.101981019836616,-1.70604038615044,-4.61352249019405,-0.390048119013827,"PAPD4","poly(A) RNA polymerase D4, non-canonical",TRUE
+"1556277_a_at",0.7768734672127,0.29467176383378,-1.07333569542608,-5.3936194962392,-0.403563217504921,"PAPD4","poly(A) RNA polymerase D4, non-canonical",TRUE
+"238706_at",0.927217810817605,0.681733664742514,-0.415553566796951,-5.85592330945526,-0.207026601311859,"PAPD4","poly(A) RNA polymerase D4, non-canonical",TRUE
+"229043_at",0.954614142466984,0.793091675857566,-0.265483298048363,-5.90541278454488,-0.277249172795708,"PAPD5","poly(A) RNA polymerase D5, non-canonical",TRUE
+"226843_s_at",0.999172777175476,0.997327025908998,0.00338808367957005,-5.9396778896989,0.00218719216086072,"PAPD5","poly(A) RNA polymerase D5, non-canonical",TRUE
+"202466_at",0.53333138995891,0.0421982915951028,2.15603112753511,-3.89840066376634,0.682204249426004,"PAPD7","poly(A) RNA polymerase D7, non-canonical",TRUE
+"226435_at",0.358427723880268,0.010130332232808,2.81120838939349,-2.68503244113874,1.98228554039592,"PAPLN","papilin, proteoglycan like sulfated glycoprotein",TRUE
+"233896_s_at",0.654826820947014,0.123720082194538,1.6001882278913,-4.76398848988533,0.76893991373054,"PAPLN","papilin, proteoglycan like sulfated glycoprotein",TRUE
+"228569_at",0.675447258877226,0.141785243532399,-1.52347983336661,-4.86833378781809,-0.847846843012217,"PAPOLA","poly(A) polymerase alpha",TRUE
+"212718_at",0.690015152288705,0.159699138426552,-1.45497177385922,-4.95806097438435,-0.331205629119625,"PAPOLA","poly(A) polymerase alpha",TRUE
+"209388_at",0.73223722457785,0.216468352485272,-1.27226872874982,-5.18061828134787,-0.537426508232631,"PAPOLA","poly(A) polymerase alpha",TRUE
+"215374_at",0.842167419664876,0.435425136358012,0.794337166508706,-5.63694646338543,0.300990850434645,"PAPOLA","poly(A) polymerase alpha",TRUE
+"212720_at",0.88767000285873,0.552453083172357,-0.603273210917622,-5.76396024710586,-0.176754263211318,"PAPOLA","poly(A) polymerase alpha",TRUE
+"222035_s_at",0.930820302962216,0.693279297321401,-0.399596997760841,-5.86220817831847,-0.163185137885275,"PAPOLA","poly(A) polymerase alpha",TRUE
+"242158_at",0.608844189052929,0.0814576176117454,1.82536022909972,-4.43533284839592,1.19798737839594,"PAPOLB","poly(A) polymerase beta",TRUE
+"208271_at",0.695739345331756,0.16519169580617,-1.43521860076884,-4.98331077341517,-0.952196469157121,"PAPOLB","poly(A) polymerase beta",TRUE
+"222273_at",0.702621412021935,0.174056497262093,1.40442353355013,-5.0221107762955,0.58957815022271,"PAPOLG","poly(A) polymerase gamma",TRUE
+"222839_s_at",0.729083413548563,0.211151439822193,1.2876616791448,-5.16283641586052,0.325332907576131,"PAPOLG","poly(A) polymerase gamma",TRUE
+"1556929_at",0.73210946530771,0.215837011547214,1.27408117189259,-5.17853402897718,0.671299138833264,"PAPOLG","poly(A) polymerase gamma",TRUE
+"224427_s_at",0.862639573412331,0.486053690922332,0.708449157152426,-5.69813914651884,0.170933158645843,"PAPOLG","poly(A) polymerase gamma",TRUE
+"219160_s_at",0.888750194607196,0.555472034616057,-0.598658776367202,-5.76661534688961,-0.236851371668743,"PAPOLG","poly(A) polymerase gamma",TRUE
+"201981_at",0.0550194051692779,8.90211146420646e-05,4.7766938703851,1.47404200792452,4.4166849749406,"PAPPA","pappalysin 1",TRUE
+"228128_x_at",0.123006402791315,0.000698683403978234,3.93522377036234,-0.340314266628504,4.28559054337824,"PAPPA","pappalysin 1",TRUE
+"224942_at",0.142607803108174,0.000960133299732959,3.80484246858804,-0.620699837209972,3.36492304154477,"PAPPA","pappalysin 1",TRUE
+"224941_at",0.152865811663982,0.00112726796973226,3.73884113931928,-0.762204990878391,4.395860371998,"PAPPA","pappalysin 1",TRUE
+"224940_s_at",0.194385040981272,0.0020836800748587,3.48467075381296,-1.30328352825626,3.97846481981494,"PAPPA","pappalysin 1",TRUE
+"201982_s_at",0.287065403341423,0.00487236752264912,3.1274191003366,-2.04832301382888,2.01726904994343,"PAPPA","pappalysin 1",TRUE
+"1559400_s_at",0.40129202983775,0.0143791420800736,2.65604000199522,-2.98705377322583,2.41217370670352,"PAPPA","pappalysin 1",TRUE
+"232748_at",0.411110107932987,0.0161547311873952,2.60377693116549,-3.08697163318464,1.50096983889149,"PAPPA","pappalysin 1",TRUE
+"1559928_at",0.700061364939874,0.171838093665845,1.41200997871203,-5.01261649541685,0.524992817375899,"PAPPA","pappalysin 1",TRUE
+"1558608_a_at",0.837368340567858,0.420796556755662,0.820275505936684,-5.61717062358959,0.554870638531122,"PAPPA","pappalysin 1",TRUE
+"1558607_at",0.992984076039555,0.966535401162443,-0.0424307110366547,-5.93880662726407,-0.033479479625723,"PAPPA","pappalysin 1",TRUE
+"213332_at",0.628431683645179,0.0996188161684387,1.71866506697437,-4.59509078184578,0.512878769575919,"PAPPA2","pappalysin 2",TRUE
+"214689_at",0.726636642789909,0.205889055323891,-1.30319460195691,-5.14470862845479,-0.83692791804777,"PAPPA2","pappalysin 2",TRUE
+"211918_x_at",0.897699110987203,0.58507506968334,0.554077701889797,-5.79125022989439,0.165768607172131,"PAPPA2","pappalysin 2",TRUE
+"228237_at",0.977567227646254,0.89206697190589,-0.137257423284732,-5.9305115698817,-0.0806826122154742,"PAPPA2","pappalysin 2",TRUE
+"209043_at",0.98529096111871,0.927025435872801,0.0926357734963005,-5.93550466792562,0.0359048919774843,"PAPSS1","3'-phosphoadenosine 5'-phosphosulfate synthase 1",TRUE
+"203060_s_at",0.824541923419694,0.391964356434451,0.873116123317418,-5.57504812884434,1.59232584443047,"PAPSS2","3'-phosphoadenosine 5'-phosphosulfate synthase 2",TRUE
+"203058_s_at",0.89316156038085,0.566916411438728,0.581283455997166,-5.77643609669274,1.00165145330521,"PAPSS2","3'-phosphoadenosine 5'-phosphosulfate synthase 2",TRUE
+"203059_s_at",0.960819760730297,0.821917572728096,0.227765080397364,-5.91444768000439,0.243107573977513,"PAPSS2","3'-phosphoadenosine 5'-phosphosulfate synthase 2",TRUE
+"1557576_at",0.760439386481756,0.259237899388905,1.15789151183055,-5.30695312337918,0.481364865565694,"PAQR3","progestin and adipoQ receptor family member 3",TRUE
+"213372_at",0.909052380289506,0.622049337543818,0.499935544501636,-5.8186768458435,0.206135359598932,"PAQR3","progestin and adipoQ receptor family member 3",TRUE
+"212858_at",0.736223289546449,0.2216938199538,-1.25742134210204,-5.19759675042936,-0.376474013840653,"PAQR4","progestin and adipoQ receptor family member 4",TRUE
+"220333_at",0.705639263092475,0.177700145330484,1.39212883570918,-5.03740768901581,1.31379573596557,"PAQR5","progestin and adipoQ receptor family member 5",TRUE
+"242871_at",0.831013183269159,0.404952217527384,0.84901645687444,-5.59456359179338,0.74963623641915,"PAQR5","progestin and adipoQ receptor family member 5",TRUE
+"219236_at",0.877239519796964,0.526584381156586,-0.643374887451287,-5.74005920285748,-0.493803899398984,"PAQR6","progestin and adipoQ receptor family member 6",TRUE
+"242123_at",0.568712535922583,0.0586282381340882,1.99377942643657,-4.16935731502199,0.744412579851731,"PAQR7","progestin and adipoQ receptor family member 7",TRUE
+"226423_at",0.731548533938014,0.215197104708481,1.27592237428333,-5.17641411146567,0.606365907162696,"PAQR8","progestin and adipoQ receptor family member 8",TRUE
+"227626_at",0.788039658538346,0.31419252887933,1.02984904518501,-5.43590461702864,0.505539039033184,"PAQR8","progestin and adipoQ receptor family member 8",TRUE
+"1558322_a_at",0.810602600845179,0.354767437322803,0.945167363595119,-5.51369199709559,0.754038511928905,"PAQR9","progestin and adipoQ receptor family member 9",TRUE
+"1560467_at",0.970274748961658,0.858759299238915,0.180037859192217,-5.92390831668296,0.138387463701176,"PAQR9","progestin and adipoQ receptor family member 9",TRUE
+"210094_s_at",0.606138724709726,0.0798072937675353,1.83604637149151,-4.41894811294016,0.704348274952757,"PARD3","par-3 family cell polarity regulator",TRUE
+"221526_x_at",0.620912785033482,0.0908882004610979,1.76766158765766,-4.52260263177754,0.72420400358215,"PARD3","par-3 family cell polarity regulator",TRUE
+"221280_s_at",0.819337312695667,0.376288247312084,-0.902904744334983,-5.55022578909303,-0.735539159610769,"PARD3","par-3 family cell polarity regulator",TRUE
+"221527_s_at",0.928295253101366,0.685401121991627,0.410473277296106,-5.85795057165296,0.190316242570885,"PARD3","par-3 family cell polarity regulator",TRUE
+"230545_at",0.827985973549523,0.397570806798329,0.862650925829105,-5.58358508887225,0.706934648287603,"PARD3-AS1","PARD3 antisense RNA 1",TRUE
+"228411_at",0.655745626967443,0.124218408375805,-1.59795121076446,-4.76708824376864,-0.974805996968746,"PARD3B","par-3 family cell polarity regulator beta",TRUE
+"239192_at",0.705559553212919,0.177204942607259,1.3937879286154,-5.0353499535822,0.857981190752741,"PARD3B","par-3 family cell polarity regulator beta",TRUE
+"1555113_at",0.877857073443889,0.528896206062649,0.639748547327205,-5.74228139001528,0.18895497602597,"PARD3B","par-3 family cell polarity regulator beta",TRUE
+"1553190_s_at",0.890353193998525,0.558799863924421,0.593587366818619,-5.76951066701864,0.360655372611341,"PARD3B","par-3 family cell polarity regulator beta",TRUE
+"1553188_s_at",0.932091525948902,0.700228585100918,-0.390043692263393,-5.8658550096504,-0.130588698857951,"PARD3B","par-3 family cell polarity regulator beta",TRUE
+"205245_at",0.899994925762288,0.594070724659551,-0.540756417793795,-5.79825260765389,-0.246176656103867,"PARD6A","par-6 family cell polarity regulator alpha",TRUE
+"235165_at",0.649509378726358,0.120047820164241,-1.61690930747444,-4.74071219856398,-1.14203340794442,"PARD6B","par-6 family cell polarity regulator beta",TRUE
+"211907_s_at",0.764077045023402,0.264042306705888,1.14594980988689,-5.31954469933664,1.10377865554388,"PARD6B","par-6 family cell polarity regulator beta",TRUE
+"214827_at",0.916349280948806,0.64666914161953,0.464716163870239,-5.83504068964714,0.597575281864537,"PARD6B","par-6 family cell polarity regulator beta",TRUE
+"227204_at",0.624986844272501,0.0962828383961093,-1.73693597645404,-4.56823634989588,-1.24496128665642,"PARD6G","par-6 family cell polarity regulator gamma",TRUE
+"232132_at",0.742774269170562,0.233028020833702,-1.22611383292148,-5.23283643810945,-1.36352224729491,"PARD6G","par-6 family cell polarity regulator gamma",TRUE
+"224538_s_at",0.94118897722809,0.736427886921018,-0.340849312658034,-5.8832552151038,-0.194720675178333,"PARD6G","par-6 family cell polarity regulator gamma",TRUE
+"1557590_at",0.969270009913181,0.854216271197393,-0.185897842776834,-5.92286555277635,-0.0699378079405033,"PARD6G-AS1","PARD6G antisense RNA 1",TRUE
+"230477_at",0.996544286433033,0.982783135335513,-0.0218247163420201,-5.93945148635738,-0.0150593940127361,"PARD6G-AS1","PARD6G antisense RNA 1",TRUE
+"205060_at",0.961653066569154,0.826221358977339,-0.222163865123688,-5.91567216381633,-0.0625294036992692,"PARG","poly(ADP-ribose) glycohydrolase",TRUE
+"1555668_a_at",0.873405654736848,0.518675961657992,-0.655846416778101,-5.732324706691,-0.274504694668741,"PARK2","parkin RBR E3 ubiquitin protein ligase",TRUE
+"1554855_at",0.89961817630669,0.590444322881924,-0.546114566158294,-5.79545598165914,-0.171122101936808,"PARK2","parkin RBR E3 ubiquitin protein ligase",TRUE
+"207058_s_at",0.89967769475675,0.591155711467528,0.545062191390643,-5.79600737163497,0.343227411502814,"PARK2","parkin RBR E3 ubiquitin protein ligase",TRUE
+"200006_at",0.994587495898891,0.974968318795667,0.0317339918263785,-5.93919299755979,0.0073523537305924,"PARK7","Parkinsonism associated deglycase",TRUE
+"228881_at",0.817055852876968,0.369381165367953,0.916289224827698,-5.53882216695039,0.320217085401829,"PARL","presenilin associated rhomboid like",TRUE
+"218271_s_at",0.998709719538178,0.99413617871226,-0.00743264542904957,-5.93965657336313,-0.00239842219911957,"PARL","presenilin associated rhomboid like",TRUE
+"225809_at",0.817889575750373,0.370814699491952,0.913497784439514,-5.54121326080044,1.1514190940659,"PARM1","prostate androgen-regulated mucin-like protein 1",TRUE
+"204687_at",0.869082033398093,0.505868921719511,0.676268398086755,-5.71935223821883,0.481836353227574,"PARM1","prostate androgen-regulated mucin-like protein 1",TRUE
+"203905_at",0.764312283028184,0.2643260342026,-1.14524961599267,-5.32027943492454,-0.395033201880546,"PARN","poly(A)-specific ribonuclease",TRUE
+"208644_at",0.931582451098271,0.697708006356907,-0.393504459375419,-5.86454395499478,-0.152619869405957,"PARP1","poly(ADP-ribose) polymerase 1",TRUE
+"238083_at",0.522667179791589,0.0385041130932164,2.20029186990207,-3.82216105491091,1.09486092820602,"PARP10","poly(ADP-ribose) polymerase family member 10",TRUE
+"229350_x_at",0.73223722457785,0.216343368953319,1.27262720624392,-5.18020624453092,1.61738147887323,"PARP10","poly(ADP-ribose) polymerase family member 10",TRUE
+"226401_at",0.812302873476553,0.357715749088338,0.939277834725505,-5.5188753014675,0.777496746820337,"PARP10","poly(ADP-ribose) polymerase family member 10",TRUE
+"228669_x_at",0.921305759692708,0.6644185844478,0.439692684433853,-5.84595591051787,0.239124678891871,"PARP10","poly(ADP-ribose) polymerase family member 10",TRUE
+"229138_at",0.468591857727704,0.0246830278967679,-2.41015104590548,-3.44828141889496,-1.66662048138099,"PARP11","poly(ADP-ribose) polymerase family member 11",TRUE
+"1554116_s_at",0.83633038614858,0.417908006980933,-0.825463586574023,-5.61314365032506,-0.424607044766476,"PARP11","poly(ADP-ribose) polymerase family member 11",TRUE
+"220315_at",0.87579870142401,0.523592653236507,-0.648080655774895,-5.73715756440825,-0.489173108029415,"PARP11","poly(ADP-ribose) polymerase family member 11",TRUE
+"218543_s_at",0.690330257199992,0.159881563998179,1.45430697159367,-4.95891533655238,0.968903859579997,"PARP12","poly(ADP-ribose) polymerase family member 12",TRUE
+"224701_at",0.547195868806649,0.0475578851184797,2.09767271614017,-3.99743330141509,1.29095954439654,"PARP14","poly(ADP-ribose) polymerase family member 14",TRUE
+"232610_at",0.806649582904638,0.347829365643525,0.959158508307223,-5.50125954921872,0.36759763855033,"PARP14","poly(ADP-ribose) polymerase family member 14",TRUE
+"1553380_at",0.595927404748624,0.0722969534562223,1.88724822583393,-4.33950015823999,0.949597142966383,"PARP15","poly(ADP-ribose) polymerase family member 15",TRUE
+"1564310_a_at",0.830635993561085,0.40407906217905,-0.850620940743698,-5.5932801198487,-0.632280729948248,"PARP15","poly(ADP-ribose) polymerase family member 15",TRUE
+"219034_at",0.576675680499645,0.0613610261959123,-1.97084310675953,-4.20652803367984,-0.680578459334699,"PARP16","poly(ADP-ribose) polymerase family member 16",TRUE
+"214086_s_at",0.789224993491684,0.315459202631529,1.02709402948492,-5.43853047951704,0.385203377815181,"PARP2","poly(ADP-ribose) polymerase 2",TRUE
+"215773_x_at",0.820536502908875,0.380571048333773,0.894686870304233,-5.557150609645,0.300462794126151,"PARP2","poly(ADP-ribose) polymerase 2",TRUE
+"204752_x_at",0.841420204214686,0.432125232382781,0.800140472247904,-5.63257375431244,0.286200072811528,"PARP2","poly(ADP-ribose) polymerase 2",TRUE
+"209940_at",0.872949023638115,0.51732503319058,0.657987267210925,-5.73098268234738,0.301961273933615,"PARP3","poly(ADP-ribose) polymerase family member 3",TRUE
+"202239_at",0.728671251879936,0.210223404297619,1.29037901543714,-5.1596784583633,0.894336741077664,"PARP4","poly(ADP-ribose) polymerase family member 4",TRUE
+"234710_s_at",0.741260241503758,0.231748207833069,-1.22959013793882,-5.22896129953054,-0.38946123072342,"PARP6","poly(ADP-ribose) polymerase family member 6",TRUE
+"232683_s_at",0.812302873476553,0.359487153095712,-0.935754985435912,-5.52196150232757,-0.364578274052869,"PARP6","poly(ADP-ribose) polymerase family member 6",TRUE
+"219639_x_at",0.81836001261482,0.371546865456494,-0.91207484125691,-5.54242953722508,-0.327837333578715,"PARP6","poly(ADP-ribose) polymerase family member 6",TRUE
+"219033_at",0.542476690934517,0.0455819554106765,2.11846399992274,-3.96234882587869,1.73058922854655,"PARP8","poly(ADP-ribose) polymerase family member 8",TRUE
+"244008_at",0.591331966259927,0.0688508928128058,1.91231496060909,-4.30004578850308,1.02109562097353,"PARP8","poly(ADP-ribose) polymerase family member 8",TRUE
+"227807_at",0.845487921422997,0.44273103228789,0.781584453544612,-5.64645017269649,0.323233860351317,"PARP9","poly(ADP-ribose) polymerase family member 9",TRUE
+"223220_s_at",0.871744769522775,0.514135067515354,0.663054806240996,-5.72778930880643,0.444126163273076,"PARP9","poly(ADP-ribose) polymerase family member 9",TRUE
+"227928_at",0.348315303925496,0.00907180599524291,-2.85952785876756,-2.58946254525243,-1.12625254706018,"PARPBP","PARP1 binding protein",TRUE
+"220060_s_at",0.542397752248982,0.04550586347976,-2.11928076201552,-3.96096606878142,-0.810475046432414,"PARPBP","PARP1 binding protein",TRUE
+"224147_at",0.967701855457407,0.848232490586122,0.193626444599095,-5.92143937964624,0.145398493616807,"PARPBP","PARP1 binding protein",TRUE
+"227348_at",0.627938764248877,0.0993202007503979,-1.72027910899972,-4.59272699904009,-0.695120764492962,"PARS2","prolyl-tRNA synthetase 2, mitochondrial (putative)",TRUE
+"205833_s_at",0.790240875783718,0.319707191924126,-1.01791091395721,-5.44723720830764,-1.03364433885374,"PART1","prostate androgen-regulated transcript 1 (non-protein coding)",TRUE
+"215972_at",0.831971841409434,0.408293890236816,0.842896220982712,-5.59943858181426,0.318884201407516,"PART1","prostate androgen-regulated transcript 1 (non-protein coding)",TRUE
+"205834_s_at",0.947460771104852,0.760775908057525,0.308244050586557,-5.89351113657296,0.192418356508112,"PART1","prostate androgen-regulated transcript 1 (non-protein coding)",TRUE
+"238887_at",0.996140682541913,0.980762955114286,0.0243860721132119,-5.9393938379477,0.0127840462575639,"PARTICL","promoter of MAT2A antisense radiation-induced circulating long non-coding RNA",TRUE
+"222455_s_at",0.625490878792938,0.096697776030314,1.73463422325822,-4.57163107227015,0.92064667737095,"PARVA","parvin alpha",TRUE
+"222454_s_at",0.632949074657601,0.10378309563742,1.6965754843083,-4.62727411995924,1.303414060078,"PARVA","parvin alpha",TRUE
+"217890_s_at",0.678126513742682,0.145413849342799,1.5090543953493,-4.8875024701729,1.0014570200614,"PARVA","parvin alpha",TRUE
+"1563458_at",0.76672996093009,0.267917254752069,1.13643451724757,-5.32949555207172,0.40700369292574,"PARVA","parvin alpha",TRUE
+"215418_at",0.782257848574678,0.304317911120644,1.05159942475728,-5.41495151869108,0.568723069964743,"PARVA","parvin alpha",TRUE
+"235279_at",0.819018525257656,0.373160162882906,0.908945991027778,-5.54509780354481,0.38356025220104,"PARVA","parvin alpha",TRUE
+"213675_at",0.87927534655779,0.5332542101496,0.632935910834699,-5.74642345297019,0.413397748901798,"PARVA","parvin alpha",TRUE
+"37965_at",0.478691006415319,0.0268080326330347,2.37174490130993,-3.5181611892902,1.44560610635454,"PARVB","parvin beta",TRUE
+"216254_at",0.497725944448536,0.0304754684716041,2.31162211819888,-3.62627828078375,1.65195564779535,"PARVB","parvin beta",TRUE
+"204629_at",0.497871139123625,0.0309331186027061,2.30459232014714,-3.63881551002892,1.56738944901032,"PARVB","parvin beta",TRUE
+"216253_s_at",0.522042520786155,0.0380559724067071,2.20592053729824,-3.81239733972032,1.71721952987828,"PARVB","parvin beta",TRUE
+"37966_at",0.588984479037728,0.0676301560443647,1.92145912675872,-4.28556302935958,2.15474003334897,"PARVB","parvin beta",TRUE
+"229822_at",0.758189649141895,0.25515664461291,1.16816512602804,-5.29602877271154,1.28906412233382,"PARVB","parvin beta",TRUE
+"244229_at",0.281385315744461,0.00473993371377501,3.1391494423319,-2.02423776634218,1.78135877932069,"PARVG","parvin gamma",TRUE
+"233510_s_at",0.741143136625128,0.231343049922735,-1.23069368707887,-5.22772916099409,-0.684826885647099,"PARVG","parvin gamma",TRUE
+"223562_at",0.823506152784717,0.390342669512002,-0.876161275915639,-5.57254609089552,-0.442322263100403,"PARVG","parvin gamma",TRUE
+"240687_at",0.896118799730606,0.578435002439892,-0.563975995143379,-5.78594005212734,-0.499227113423048,"PASD1","PAS domain containing 1",TRUE
+"216945_x_at",0.94895689004559,0.767609025036794,0.299156066784709,-5.89618784040123,0.108773814633389,"PASK","PAS domain containing serine/threonine kinase",TRUE
+"206594_at",0.968980656821882,0.853352411606834,0.187012870028452,-5.9226633680277,0.101622499832369,"PASK","PAS domain containing serine/threonine kinase",TRUE
+"213534_s_at",0.990810941805126,0.955104277998338,0.0569388461158827,-5.93810452976121,0.0207920809107147,"PASK","PAS domain containing serine/threonine kinase",TRUE
+"243468_at",0.605074025447346,0.0789581145611812,1.84161991960266,-4.41037520898227,1.01176382913762,"PATE1","prostate and testis expressed 1",TRUE
+"231279_at",0.988404376556799,0.944653165670932,-0.0702140614434494,-5.93728253774002,-0.0498755103269719,"PATE1","prostate and testis expressed 1",TRUE
+"243268_at",0.871744769522775,0.513581393142807,0.663936142642161,-5.72723152637488,0.302036564147716,"PATE2","prostate and testis expressed 2",TRUE
+"239173_at",0.51470556386048,0.0353632280628943,2.24106791503915,-3.75108724423441,1.22278104714317,"PATJ","PATJ, crumbs cell polarity complex component",TRUE
+"214493_s_at",0.559434208511607,0.0539407963258984,2.03542951556883,-4.10112446907852,0.958905486120513,"PATJ","PATJ, crumbs cell polarity complex component",TRUE
+"232041_at",0.631360647647282,0.102675990073062,1.70237353733954,-4.61885690293791,0.957504882856463,"PATJ","PATJ, crumbs cell polarity complex component",TRUE
+"214705_at",0.711989638658417,0.186096687525108,1.36454139368785,-5.0713255376622,1.20932800162512,"PATJ","PATJ, crumbs cell polarity complex component",TRUE
+"223681_s_at",0.929191341566013,0.688595789255999,0.406056855030664,-5.85969298500429,0.304711541157717,"PATJ","PATJ, crumbs cell polarity complex component",TRUE
+"240570_at",0.959120911159536,0.814559600073155,-0.237358596787524,-5.91227997488327,-0.237527816832434,"PATJ","PATJ, crumbs cell polarity complex component",TRUE
+"244342_at",0.731548533938014,0.214949952022469,1.2766346347,-5.17559333078335,0.641284171853149,"PATL1","PAT1 homolog 1, processing body mRNA decay factor",TRUE
+"235235_s_at",0.82153774281298,0.383867452898389,0.888402977904108,-5.5624062171812,0.320573985053354,"PATL1","PAT1 homolog 1, processing body mRNA decay factor",TRUE
+"225468_at",0.937113154905832,0.719988210270096,0.363077053283754,-5.87567958158323,0.126549808608299,"PATL1","PAT1 homolog 1, processing body mRNA decay factor",TRUE
+"235234_at",0.950926616697165,0.775902836983173,-0.288159741179932,-5.89932041976326,-0.0936321640907689,"PATL1","PAT1 homolog 1, processing body mRNA decay factor",TRUE
+"225466_at",0.980570785147084,0.90925034118957,0.115294340391406,-5.93321112856028,0.0459581519783683,"PATL1","PAT1 homolog 1, processing body mRNA decay factor",TRUE
+"230753_at",0.755639383619058,0.249770521454837,1.18191211890941,-5.28127898097943,0.836387845594348,"PATL2","PAT1 homolog 2",TRUE
+"209431_s_at",0.615637099066718,0.0858879359027735,-1.79757383235603,-4.47761406949037,-1.00609504848237,"PATZ1","POZ/BTB and AT hook containing zinc finger 1",TRUE
+"210581_x_at",0.69410086222651,0.163531580196304,-1.44113242169389,-4.97578085796013,-0.636367955821274,"PATZ1","POZ/BTB and AT hook containing zinc finger 1",TRUE
+"209494_s_at",0.722362743674536,0.19887691077923,-1.32437889150956,-5.11968900510986,-0.956277951880525,"PATZ1","POZ/BTB and AT hook containing zinc finger 1",TRUE
+"211391_s_at",0.729273475042162,0.211751706905398,-1.28590897812549,-5.16487031629034,-0.643454105607704,"PATZ1","POZ/BTB and AT hook containing zinc finger 1",TRUE
+"211392_s_at",0.73223722457785,0.216402612111898,-1.27245726529171,-5.18040158833882,-0.645912709463802,"PATZ1","POZ/BTB and AT hook containing zinc finger 1",TRUE
+"211393_at",0.838303520227789,0.423114770749687,0.816127941515326,-5.62037283880252,0.462206874848624,"PATZ1","POZ/BTB and AT hook containing zinc finger 1",TRUE
+"229515_at",0.597654932724127,0.0750513421373546,1.86795374597623,-4.36962022080603,0.694112392289241,"PAWR","pro-apoptotic WT1 regulator",TRUE
+"204005_s_at",0.622434989367596,0.0925846693804627,1.75783440823968,-4.537262135542,0.530530273928541,"PAWR","pro-apoptotic WT1 regulator",TRUE
+"204004_at",0.715973143624306,0.19163425753623,1.34688132269023,-5.09274081279397,0.398103103281363,"PAWR","pro-apoptotic WT1 regulator",TRUE
+"1558017_s_at",0.72618569821667,0.205178174047574,1.30531642891328,-5.14221803043182,0.639015239168918,"PAWR","pro-apoptotic WT1 regulator",TRUE
+"214090_at",0.761748280722165,0.26097979790761,1.15354314824474,-5.31155140663256,0.936878509793528,"PAWR","pro-apoptotic WT1 regulator",TRUE
+"226231_at",0.827006487802341,0.395357041542435,0.866771751639232,-5.58023495827855,0.247256663206793,"PAWR","pro-apoptotic WT1 regulator",TRUE
+"226223_at",0.93919895813272,0.727997290272788,0.352225561306239,-5.87943703471741,0.125579436444044,"PAWR","pro-apoptotic WT1 regulator",TRUE
+"214237_x_at",0.983895747353418,0.921145962789698,-0.100124460344085,-5.93480189718776,-0.030164473397547,"PAWR","pro-apoptotic WT1 regulator",TRUE
+"231445_at",0.818813124200374,0.37251317149264,-0.910199696433397,-5.54402966640952,-0.387022995441828,"PAX1","paired box 1",TRUE
+"214401_at",0.883114005048829,0.540781388911796,0.621239458939341,-5.75343531513091,0.293691053945147,"PAX1","paired box 1",TRUE
+"1553492_a_at",0.900873848041424,0.596924696238586,-0.536550804721522,-5.80042890176781,-0.34204750888586,"PAX1","paired box 1",TRUE
+"206228_at",0.780550841585083,0.302012858778828,-1.05674840730152,-5.40993366590395,-0.794884871349169,"PAX2","paired box 2",TRUE
+"206229_x_at",0.979588787486838,0.902392169348133,-0.124052594374068,-5.93219082227993,-0.0649999139157131,"PAX2","paired box 2",TRUE
+"231666_at",0.769774279128662,0.27722751196942,1.11397794978539,-5.35268937136759,1.10238303090909,"PAX3","paired box 3",TRUE
+"207679_at",0.840872144163754,0.43028929142954,-0.803381089113725,-5.63011897789704,-0.708246203148498,"PAX3","paired box 3",TRUE
+"216059_at",0.969882914559333,0.856808237671118,-0.182553701556907,-5.92346470926111,-0.128346023802516,"PAX3","paired box 3",TRUE
+"207680_x_at",0.990984475090957,0.957888221748185,0.053404492788092,-5.9382944527615,0.0403813629122753,"PAX3","paired box 3",TRUE
+"207867_at",0.523369751179323,0.0389070668409294,2.19528130675615,-3.83083973072567,1.41998836101806,"PAX4","paired box 4",TRUE
+"211176_s_at",0.719412173140763,0.19546168874268,-1.33490830970721,-5.10712679590286,-1.09117786881612,"PAX4","paired box 4",TRUE
+"221969_at",0.67747053724365,0.144824428702401,1.51137741199548,-4.88442545735583,0.750297003469344,"PAX5","paired box 5",TRUE
+"206802_at",0.90344422113846,0.60435933563978,-0.525640688164798,-5.80599752207574,-0.271950894439314,"PAX5","paired box 5",TRUE
+"205646_s_at",0.46695150806163,0.0244514342492994,2.41451979541116,-3.44029323946438,3.0315385010445,"PAX6","paired box 6",TRUE
+"235795_at",0.588647704922709,0.0671817408087371,1.9248545198931,-4.28017314551366,3.38211480825146,"PAX6","paired box 6",TRUE
+"208060_at",0.83030603167465,0.402481591960397,0.853562155408104,-5.59092149357399,0.60278494018455,"PAX7","paired box 7",TRUE
+"1556638_at",0.86219003266709,0.485137104689184,0.70995577465334,-5.69712296616604,0.329655252896523,"PAX7","paired box 7",TRUE
+"221990_at",0.754513748034606,0.247956988918071,1.18659054200518,-5.27622491978866,0.550659876823443,"PAX8","paired box 8",TRUE
+"207924_x_at",0.827667049362122,0.396493010642756,0.864655341239027,-5.58195740303181,0.886867620562198,"PAX8","paired box 8",TRUE
+"207921_x_at",0.867099100798202,0.49895036740232,0.687421459482443,-5.71210692387817,0.490410775361877,"PAX8","paired box 8",TRUE
+"207923_x_at",0.923935703779429,0.672925448224891,-0.427800902881463,-5.8509352894945,-0.430743429061541,"PAX8","paired box 8",TRUE
+"121_at",0.966064677476069,0.841657948075168,0.202132024298603,-5.9198029397716,0.0753358446713328,"PAX8","paired box 8",TRUE
+"213917_at",0.968269082055813,0.850771427407479,-0.190345728596798,-5.92205184657531,-0.103791211322097,"PAX8","paired box 8",TRUE
+"209552_at",0.990275275228902,0.951479305598535,0.0615420478481398,-5.93783893468515,0.0665201162443365,"PAX8","paired box 8",TRUE
+"214528_s_at",0.995111934465262,0.977501026313912,0.0285221825985432,-5.93928725540314,0.0363566040173913,"PAX8","paired box 8",TRUE
+"228425_at",0.672434875127089,0.13847177428543,1.53691962091964,-4.85034429365054,2.41880855181727,"PAX8-AS1","PAX8 antisense RNA 1",TRUE
+"227474_at",0.777562247899264,0.296563735590924,1.06903278589229,-5.39787340738847,1.36325240405838,"PAX8-AS1","PAX8 antisense RNA 1",TRUE
+"207059_at",0.740634842876843,0.230746065821243,-1.23232239973494,-5.22590892285444,-0.591663916285472,"PAX9","paired box 9",TRUE
+"231145_at",0.83030603167465,0.40247267073788,-0.853578601872439,-5.59090828345116,-0.934354733646335,"PAX9","paired box 9",TRUE
+"1555125_at",0.801086839730802,0.337455852939959,0.980436181659065,-5.48203247140442,0.377961362331869,"PAXBP1","PAX3 and PAX7 binding protein 1",TRUE
+"221158_at",0.812498481719966,0.361065854784636,0.932625180388317,-5.52469443831393,0.268027982857273,"PAXBP1","PAX3 and PAX7 binding protein 1",TRUE
+"218515_at",0.942324052902057,0.740987296378116,-0.334715996395449,-5.88526229737402,-0.0922905833493246,"PAXBP1","PAX3 and PAX7 binding protein 1",TRUE
+"1556789_a_at",0.558461161038969,0.0527193921312011,-2.04681100185455,-4.08231650963292,-0.611288240743317,"PAXBP1-AS1","PAXBP1 antisense RNA 1",TRUE
+"239407_at",0.95617685641848,0.801649582466697,0.254246807580246,-5.90824797088387,0.193438721609604,"PAXBP1-AS1","PAXBP1 antisense RNA 1",TRUE
+"212825_at",0.715549750539287,0.191272880516904,-1.34802146075454,-5.09136528374038,-0.461214403910533,"PAXIP1","PAX interacting protein 1",TRUE
+"235587_at",0.557512088623721,0.0522759305121148,-2.05100164406382,-4.07537410010567,-1.0752792424487,"PAXIP1-AS1","PAXIP1 antisense RNA 1 (head to head)",TRUE
+"1558527_at",0.61760967235709,0.0880180488190287,-1.7846525113281,-4.49711554422985,-1.15497836113099,"PAXIP1-AS2","PAXIP1 antisense RNA 2",TRUE
+"1569898_a_at",0.948429371744093,0.764882291775978,0.302779470846898,-5.89513014780272,0.207665571632162,"PAXIP1-AS2","PAXIP1 antisense RNA 2",TRUE
+"224177_s_at",0.96287357728432,0.831326503305561,-0.215529108836782,-5.91708332964672,-0.0771977460819002,"PBDC1","polysaccharide biosynthesis domain containing 1",TRUE
+"223294_at",0.99739139970986,0.986829288135798,-0.0166950930615824,-5.93954772443841,-0.00609841267268507,"PBDC1","polysaccharide biosynthesis domain containing 1",TRUE
+"219148_at",0.999016635322945,0.99687287740685,0.00396373495273244,-5.93967582840829,0.00141050461310677,"PBK","PDZ binding kinase",TRUE
+"219543_at",0.535243600695458,0.0427111246797843,-2.15016640025198,-3.90843037931015,-1.21205433950617,"PBLD","phenazine biosynthesis like protein domain containing",TRUE
+"1555175_a_at",0.941161916043887,0.736352689210962,-0.340950579769575,-5.88322177374235,-0.20366619477588,"PBLD","phenazine biosynthesis like protein domain containing",TRUE
+"224257_s_at",0.664094349733756,0.13211438942943,1.5634656640052,-4.81444466819694,1.29192002607413,"PBOV1","prostate and breast cancer overexpressed 1",TRUE
+"208329_at",0.945432830098469,0.753387425233603,-0.318100593449462,-5.89051836209879,-0.244826248788293,"PBOV1","prostate and breast cancer overexpressed 1",TRUE
+"221212_x_at",0.769429807058463,0.276886568717831,-1.11479052049951,-5.35185726856963,-0.778385228756468,"PBRM1","polybromo 1",TRUE
+"223238_s_at",0.82145314869164,0.38367899832908,-0.888761271605753,-5.56210747626566,-0.348539239744802,"PBRM1","polybromo 1",TRUE
+"232613_at",0.831487912516861,0.406139485105149,0.84683831239435,-5.59630233441013,0.251678034653597,"PBRM1","polybromo 1",TRUE
+"220355_s_at",0.93474377881867,0.710200868529619,0.376398638108869,-5.87091295872363,0.118004562726414,"PBRM1","polybromo 1",TRUE
+"224152_s_at",0.937113154905832,0.719538305413736,0.36368793619845,-5.87546470907061,0.171931843126274,"PBRM1","polybromo 1",TRUE
+"223400_s_at",0.957174671135192,0.806063533445037,-0.248464453598868,-5.90965949279927,-0.102643492295909,"PBRM1","polybromo 1",TRUE
+"212148_at",0.308621629697291,0.00624296942288355,-3.0213843146054,-2.26464009470523,-2.21897433758594,"PBX1","PBX homeobox 1",TRUE
+"212151_at",0.39149295959037,0.0132300856527681,-2.69320600531935,-2.91542593139859,-1.82594165984795,"PBX1","PBX homeobox 1",TRUE
+"205253_at",0.52680460055792,0.039812649465118,-2.1841903705732,-3.8500068206939,-1.88836600185757,"PBX1","PBX homeobox 1",TRUE
+"211096_at",0.607185965693299,0.0808914965543666,-1.82900462417499,-4.42975271529066,-0.784544290800778,"PBX2","PBX homeobox 2",TRUE
+"202876_s_at",0.870808709484996,0.510234951021341,0.669274298006976,-5.72383793184701,0.415990359347898,"PBX2","PBX homeobox 2",TRUE
+"211097_s_at",0.899808883319249,0.593092955371253,0.54219952705844,-5.79750202986666,0.22573492644737,"PBX2","PBX homeobox 2",TRUE
+"202875_s_at",0.95877806139143,0.813289085692904,0.239017409026962,-5.91189613844731,0.123612353680929,"PBX2","PBX homeobox 2",TRUE
+"204082_at",0.772943317221533,0.283433755225871,-1.09931196317782,-5.36761530208718,-0.62058404261959,"PBX3","PBX homeobox 3",TRUE
+"230536_at",0.643082025527735,0.113473190503759,1.64794666911523,-4.69701306054316,1.57366783762477,"PBX4","PBX homeobox 4",TRUE
+"214176_s_at",0.846452477724539,0.444501919225411,0.778512748938943,-5.64871763934988,0.315973770765778,"PBXIP1","PBX homeobox interacting protein 1",TRUE
+"207838_x_at",0.897864687719555,0.585534036194617,-0.553395598698267,-5.79161279963,-0.521641936911608,"PBXIP1","PBX homeobox interacting protein 1",TRUE
+"214177_s_at",0.9596230131274,0.817667257660104,-0.233304026515627,-5.91320697931032,-0.10896235276422,"PBXIP1","PBX homeobox interacting protein 1",TRUE
+"212259_s_at",0.986455005400648,0.937005407904414,-0.0799364593531175,-5.93657170564656,-0.0379991652085199,"PBXIP1","PBX homeobox interacting protein 1",TRUE
+"204476_s_at",0.593904766176258,0.0706752193134252,-1.89891126008039,-4.32118806104348,-1.3708419838718,"PC","pyruvate carboxylase",TRUE
+"232575_at",0.419258213999957,0.0172581614484841,-2.57395419822703,-3.14355130348521,-1.27009988243761,"PCA3","prostate cancer associated 3 (non-protein coding)",TRUE
+"232572_at",0.904432955312383,0.608204629657709,-0.52002315306474,-5.80882132196287,-0.282031127039341,"PCA3","prostate cancer associated 3 (non-protein coding)",TRUE
+"1559276_at",0.775757729721894,0.293098314284752,-1.07692928590999,-5.39005512047952,-0.82646406213533,"PCAT18","prostate cancer associated transcript 18 (non-protein coding)",TRUE
+"230132_at",0.81390353381761,0.364805095259082,0.925248463280459,-5.53110245487537,0.550628139102761,"PCAT19","prostate cancer associated transcript 19 (non-protein coding)",TRUE
+"1554591_at",0.647010918356064,0.118029938723061,1.62628035051003,-4.72758561727079,0.496193010142564,"PCAT4","prostate cancer associated transcript 4 (non-protein coding)",TRUE
+"231096_at",0.671298718565642,0.13721151110321,1.54210090414004,-4.84337554449868,0.909882234040207,"PCAT4","prostate cancer associated transcript 4 (non-protein coding)",TRUE
+"231233_at",0.73476400096553,0.219710226827352,-1.26302548334215,-5.19120827097018,-0.653849891646763,"PCAT6","prostate cancer associated transcript 6 (non-protein coding)",TRUE
+"1559861_at",0.823518986434235,0.390567624922748,0.875738371760059,-5.57289405210679,0.953955386186905,"PCAT7","prostate cancer associated transcript 7 (non-protein coding)",TRUE
+"203557_s_at",0.867972140419125,0.501432381775552,0.683410324950046,-5.71472570527587,0.277943097201435,"PCBD1","pterin-4 alpha-carbinolamine dehydratase 1",TRUE
+"1554894_a_at",0.682825347106105,0.151064450937001,-1.48716610538768,-4.91630876586199,-0.530584756276342,"PCBD2","pterin-4 alpha-carbinolamine dehydratase 2",TRUE
+"223712_at",0.828607509614823,0.399035867908652,-0.859931906223283,-5.58578745039532,-0.297267712256458,"PCBD2","pterin-4 alpha-carbinolamine dehydratase 2",TRUE
+"240846_at",0.942502815705589,0.74251111314497,-0.332669086018557,-5.8859241102103,-0.140230721778471,"PCBD2","pterin-4 alpha-carbinolamine dehydratase 2",TRUE
+"208620_at",0.902229953331547,0.600942079752628,-0.530647313332082,-5.80345591753047,-0.134407953011333,"PCBP1","poly(rC) binding protein 1",TRUE
+"227969_at",0.759878256460865,0.257698447760354,-1.16175254087246,-5.30285745856646,-0.551370781946255,"PCBP1-AS1","PCBP1 antisense RNA 1",TRUE
+"235137_at",0.821990323055816,0.385350243572372,-0.885587870633524,-5.56474953567052,-0.763543556571675,"PCBP1-AS1","PCBP1 antisense RNA 1",TRUE
+"1562481_at",0.902064015083249,0.60047343858946,-0.531334988757987,-5.80310498867275,-0.557133443931777,"PCBP1-AS1","PCBP1 antisense RNA 1",TRUE
+"240017_at",0.94333312187812,0.745692997551137,-0.328399586339614,-5.88729160934455,-0.235129886535571,"PCBP1-AS1","PCBP1 antisense RNA 1",TRUE
+"235482_at",0.963330918782438,0.832754870513638,-0.213674555050388,-5.91747016397185,-0.0820747133247739,"PCBP1-AS1","PCBP1 antisense RNA 1",TRUE
+"235909_at",0.965955476577591,0.840482851160965,-0.203653853789581,-5.91950275599435,-0.0665109397773573,"PCBP1-AS1","PCBP1 antisense RNA 1",TRUE
+"1557727_at",0.986889306520757,0.93915534939576,0.0772025375863837,-5.93678088849501,0.0341034277029553,"PCBP1-AS1","PCBP1 antisense RNA 1",TRUE
+"1568640_at",0.991059530537351,0.958248017009804,-0.052947766874449,-5.93831810806051,-0.0368926732441315,"PCBP1-AS1","PCBP1 antisense RNA 1",TRUE
+"213263_s_at",0.587947964200177,0.0668804067284962,-1.92714742930206,-4.27652963692016,-0.711769188464633,"PCBP2","poly(rC) binding protein 2",TRUE
+"213264_at",0.62282585384278,0.0933451321626681,-1.75347933587007,-4.54373948727417,-0.714105674074828,"PCBP2","poly(rC) binding protein 2",TRUE
+"237813_at",0.773754791548713,0.285368291246606,-1.09478808336346,-5.37218388161357,-0.602161282194015,"PCBP2","poly(rC) binding protein 2",TRUE
+"204031_s_at",0.787211643646529,0.313056109150553,-1.03232741028257,-5.43353701457825,-0.260026777793939,"PCBP2","poly(rC) binding protein 2",TRUE
+"229467_at",0.841550580403629,0.43297337346248,-0.798646298993716,-5.63370245357901,-0.351551829288425,"PCBP2","poly(rC) binding protein 2",TRUE
+"213517_at",0.901910595357431,0.600121753893828,-0.531851214758434,-5.80284126186628,-0.291857769994294,"PCBP2","poly(rC) binding protein 2",TRUE
+"205663_at",0.69533015659068,0.164793565049877,-1.43663248468951,-4.98151281202752,-1.07753998356769,"PCBP3","poly(rC) binding protein 3",TRUE
+"209361_s_at",0.948668195792872,0.766506129224254,-0.300621148515082,-5.89576169470324,-0.132033632212458,"PCBP4","poly(rC) binding protein 4",TRUE
+"203860_at",0.703902004301726,0.175525922699003,-1.39944082131725,-5.02832359121122,-0.868967986394324,"PCCA","propionyl-CoA carboxylase alpha subunit",TRUE
+"216533_at",0.805746717966166,0.345463689467736,0.963972344611438,-5.49694335961731,0.870911647066246,"PCCA","propionyl-CoA carboxylase alpha subunit",TRUE
+"232376_at",0.966051687342135,0.841312225283737,0.202579707686613,-5.91971486619643,0.0705682243586798,"PCCA","propionyl-CoA carboxylase alpha subunit",TRUE
+"212694_s_at",0.895999830738594,0.576929879711731,-0.566227571427891,-5.78471940865426,-0.226625842258747,"PCCB","propionyl-CoA carboxylase beta subunit",TRUE
+"1557502_at",0.928295253101366,0.685171003491828,-0.410791721151627,-5.85782421899691,-0.24505953902039,"PCCB","propionyl-CoA carboxylase beta subunit",TRUE
+"203918_at",0.641547541078628,0.111977529102965,1.65521776326105,-4.68668365318823,1.25013856427539,"PCDH1","protocadherin 1",TRUE
+"215277_at",0.713673813939397,0.188861926804974,-1.35567166110707,-5.0821104507322,-1.009935325074,"PCDH1","protocadherin 1",TRUE
+"1556328_at",0.808585848781544,0.351580670282644,0.951570494831672,-5.50802297745584,1.15872648245175,"PCDH10","protocadherin 10",TRUE
+"228635_at",0.820288124919738,0.378565282302587,-0.898527932545615,-5.55392121251653,-1.30796779282268,"PCDH10","protocadherin 10",TRUE
+"1556329_a_at",0.976589025744684,0.888638163837313,0.141647919119302,-5.92991570382292,0.154717581922495,"PCDH10","protocadherin 10",TRUE
+"1552925_at",0.987878312181854,0.942122766101558,-0.0734300786444325,-5.9370575890278,-0.064401232547171,"PCDH10","protocadherin 10",TRUE
+"208366_at",0.579119470758542,0.0622487686587897,1.96358673054948,-4.21822709180132,1.59857763341548,"PCDH11X","protocadherin 11 X-linked",TRUE
+"217049_x_at",0.885312914741353,0.546745645423177,-0.612033303116975,-5.75886564720148,-0.385603769221028,"PCDH11Y///PCDH11X","protocadherin 11 Y-linked///protocadherin 11 X-linked",TRUE
+"211227_s_at",0.915742010892393,0.644615255604052,0.467631002042629,-5.83373075648876,0.410352122225907,"PCDH11Y///PCDH11X","protocadherin 11 Y-linked///protocadherin 11 X-linked",TRUE
+"1557880_at",0.947520029678523,0.760858150580812,0.308134512663073,-5.89354387162908,0.14138440205694,"PCDH11Y///PCDH11X","protocadherin 11 Y-linked///protocadherin 11 X-linked",TRUE
+"210292_s_at",0.980171602298162,0.906748663400478,-0.118488010311706,-5.93284771509004,-0.0900532302912884,"PCDH11Y///PCDH11X","protocadherin 11 Y-linked///protocadherin 11 X-linked",TRUE
+"219656_at",0.943345639021508,0.745859874334902,0.328175841032885,-5.88736279180449,0.208037395963206,"PCDH12","protocadherin 12",TRUE
+"1560330_at",0.965620759643697,0.839379201528779,0.205083602376996,-5.91921869222243,0.149917685073193,"PCDH15","protocadherin related 15",TRUE
+"1553344_at",0.990848691272535,0.956868969349609,0.0546984004411132,-5.93822633432141,0.0424754666936957,"PCDH15","protocadherin related 15",TRUE
+"228863_at",0.720174137377026,0.196247137671011,-1.33247403175048,-5.11003846745671,-1.7206367471975,"PCDH17","protocadherin 17",TRUE
+"205656_at",0.789661545166663,0.317214821213602,-1.02328836910072,-5.44214728772687,-0.354457393838941,"PCDH17","protocadherin 17",TRUE
+"227289_at",0.993213867476782,0.967478679302935,0.041233983075915,-5.93885538980013,0.0354483837262585,"PCDH17","protocadherin 17",TRUE
+"225975_at",0.819018525257656,0.3738150635943,0.907678423628294,-5.54617636920951,0.759374779134426,"PCDH18","protocadherin 18",TRUE
+"225977_at",0.983498417373669,0.919513826739887,0.102204334452918,-5.93459703311909,0.101641119023118,"PCDH18","protocadherin 18",TRUE
+"227282_at",0.760439386481756,0.259281867377057,-1.15778148742019,-5.30706965867637,-1.61325207302627,"PCDH19","protocadherin 19",TRUE
+"228640_at",0.670164229230396,0.136079803802759,1.54678719027058,-4.83705657206924,2.32453703688024,"PCDH7","protocadherin 7",TRUE
+"205535_s_at",0.700890836612645,0.172573983834016,1.40948476886831,-5.01578142043222,1.85021186579149,"PCDH7","protocadherin 7",TRUE
+"210273_at",0.735677568529031,0.220755912178833,1.26006635375717,-5.19458458335196,0.832034894909038,"PCDH7","protocadherin 7",TRUE
+"205534_at",0.737161440695888,0.223352838163111,1.25276361604688,-5.20288782418355,1.50342158931501,"PCDH7","protocadherin 7",TRUE
+"210941_at",0.788979966718321,0.315245658032528,1.02755794380469,-5.43808875765301,0.938684992581238,"PCDH7","protocadherin 7",TRUE
+"206935_at",0.953516309041226,0.785539317673206,-0.275428551775014,-5.90280183588698,-0.430225955972346,"PCDH8","protocadherin 8",TRUE
+"1565602_at",0.841526980254885,0.432637986062818,0.79923693553083,-5.63325652345284,0.628751754715436,"PCDH9","protocadherin 9",TRUE
+"219737_s_at",0.848364007856994,0.448342413342339,0.771876720582377,-5.65358745750098,0.850413982646888,"PCDH9","protocadherin 9",TRUE
+"219738_s_at",0.867972140419125,0.501532766872212,0.683248331559136,-5.71483115948164,0.5044711902299,"PCDH9","protocadherin 9",TRUE
+"238919_at",0.942285214854475,0.74004128308631,0.335987489296563,-5.88484917258674,0.421133507466916,"PCDH9","protocadherin 9",TRUE
+"210674_s_at",0.685154158710982,0.153605582055421,-1.47753966828956,-4.92887049436103,-2.02474480475602,"PCDHA1///PCDHA2///PCDHA3///PCDHA4///PCDHA5///PCDHA6///PCDHA7///PCDHA8///PCDHA10///PCDHA11///PCDHA12///PCDHA13///PCDHAC1///PCDHAC2///PCDHA9","protocadherin alpha 1///protocadherin alpha 2///protocadherin alpha 3///protocadherin alpha 4///protocadherin alpha 5///protocadherin alpha 6///protocadherin alpha 7///protocadherin alpha 8///protocadherin alpha 10///protocadherin alpha 11///protocadherin alpha 12///protocadherin alpha 13///protocadherin alpha subfamily C, 1///protocadherin alpha subfamily C, 2///protocadherin alpha 9",TRUE
+"223435_s_at",0.813065886130395,0.362674285905111,-0.929445856546506,-5.52746199627166,-1.27824840740754,"PCDHA1///PCDHA2///PCDHA3///PCDHA4///PCDHA5///PCDHA6///PCDHA7///PCDHA8///PCDHA10///PCDHA11///PCDHA12///PCDHA13///PCDHAC1///PCDHAC2///PCDHA9","protocadherin alpha 1///protocadherin alpha 2///protocadherin alpha 3///protocadherin alpha 4///protocadherin alpha 5///protocadherin alpha 6///protocadherin alpha 7///protocadherin alpha 8///protocadherin alpha 10///protocadherin alpha 11///protocadherin alpha 12///protocadherin alpha 13///protocadherin alpha subfamily C, 1///protocadherin alpha subfamily C, 2///protocadherin alpha 9",TRUE
+"224212_s_at",0.860026478479837,0.478597483571422,-0.720753384525063,-5.68978008695484,-0.982255972147914,"PCDHA1///PCDHA2///PCDHA3///PCDHA4///PCDHA5///PCDHA6///PCDHA7///PCDHA8///PCDHA10///PCDHA11///PCDHA12///PCDHA13///PCDHAC1///PCDHAC2///PCDHA9","protocadherin alpha 1///protocadherin alpha 2///protocadherin alpha 3///protocadherin alpha 4///protocadherin alpha 5///protocadherin alpha 6///protocadherin alpha 7///protocadherin alpha 8///protocadherin alpha 10///protocadherin alpha 11///protocadherin alpha 12///protocadherin alpha 13///protocadherin alpha subfamily C, 1///protocadherin alpha subfamily C, 2///protocadherin alpha 9",TRUE
+"211867_s_at",0.801560848966415,0.338540754490922,-0.97819010239931,-5.48408025338324,-0.743233975204818,"PCDHA10","protocadherin alpha 10",TRUE
+"211365_s_at",0.937462538530338,0.722818212253362,-0.359237678230772,-5.87702188094261,-0.150987032651974,"PCDHA2","protocadherin alpha 2",TRUE
+"211870_s_at",0.85027409706956,0.452904115755954,0.76403917487721,-5.65928830135845,0.551890149041489,"PCDHA2///PCDHA3","protocadherin alpha 2///protocadherin alpha 3",TRUE
+"210572_at",0.9802233499944,0.907012131665659,-0.118151604885016,-5.93288646250537,-0.115621599857387,"PCDHA2///PCDHA3","protocadherin alpha 2///protocadherin alpha 3",TRUE
+"211838_x_at",0.668518995965071,0.13468372761047,-1.55261270664287,-4.82918034382229,-1.08250186631492,"PCDHA5","protocadherin alpha 5",TRUE
+"211811_s_at",0.755345385769974,0.249247189192534,-1.1832595619,-5.27982513572128,-0.935623289993865,"PCDHA5///PCDHA6","protocadherin alpha 5///protocadherin alpha 6",TRUE
+"208205_at",0.818587566823571,0.371856596199306,-0.911473448229007,-5.54294305871265,-0.299778677393615,"PCDHA9","protocadherin alpha 9",TRUE
+"1553237_x_at",0.731054546207485,0.214106069846624,1.27907135289577,-5.17278239910073,0.906367777488232,"PCDHAC1","protocadherin alpha subfamily C, 1",TRUE
+"1553235_at",0.987257510450304,0.94051471791165,-0.0754742414907779,-5.93690937408043,-0.0460389625979181,"PCDHAC1","protocadherin alpha subfamily C, 1",TRUE
+"224539_s_at",0.871744769522775,0.51415431419955,-0.663024178949211,-5.72780867951847,-0.471928830271166,"PCDHAC2","protocadherin alpha subfamily C, 2",TRUE
+"221303_at",0.662575055303091,0.130430368605668,1.5706741674205,-4.80461267069987,0.655857177513465,"PCDHB1","protocadherin beta 1",TRUE
+"208504_x_at",0.817595337159201,0.370089931401062,-0.914908187248369,-5.54000597781128,-0.852892830964899,"PCDHB11","protocadherin beta 11",TRUE
+"221408_x_at",0.850964124514683,0.454003173517939,-0.762158003716013,-5.66064843890892,-0.747974822615201,"PCDHB12","protocadherin beta 12",TRUE
+"232415_at",0.838245037296515,0.422903781710828,0.816504836648107,-5.62008247742737,1.03570633787099,"PCDHB13","protocadherin beta 13",TRUE
+"221450_x_at",0.854921010321791,0.466930970414903,-0.740232577568094,-5.67626699094187,-0.795066186029641,"PCDHB13","protocadherin beta 13",TRUE
+"231726_at",0.873185408141357,0.517617313614072,-0.65752382124138,-5.73127355618036,-0.764434161312293,"PCDHB14","protocadherin beta 14",TRUE
+"231789_at",0.947969282616012,0.763562731561648,0.304534444673041,-5.89461332372497,0.301713177221212,"PCDHB15","protocadherin beta 15",TRUE
+"232099_at",0.888583087185673,0.554732283406052,-0.599788262230189,-5.76596727180035,-0.588813631081538,"PCDHB16","protocadherin beta 16",TRUE
+"216355_at",0.71242055183987,0.186558199952527,1.36305385602775,-5.07313836427827,0.741724469966341,"PCDHB17P","protocadherin beta 17 pseudogene",TRUE
+"216313_at",0.756275866957977,0.251206694464085,-1.17822514724797,-5.28524970473547,-1.27518393618371,"PCDHB17P","protocadherin beta 17 pseudogene",TRUE
+"234479_at",0.642592458809121,0.113074995592922,-1.64987455598483,-4.69427766676376,-0.948448340619725,"PCDHB18P","protocadherin beta 18 pseudogene",TRUE
+"234724_x_at",0.989669132517581,0.950291868316846,0.0630502164564284,-5.9377474296503,0.0549603277770547,"PCDHB18P","protocadherin beta 18 pseudogene",TRUE
+"231725_at",0.792257368722412,0.323173560995257,-1.01048048969656,-5.4542303988822,-1.21125132816719,"PCDHB2","protocadherin beta 2",TRUE
+"231394_at",0.7994347047598,0.334879599463686,0.985789772379299,-5.47713428212614,0.601557057767766,"PCDHB3","protocadherin beta 3",TRUE
+"244183_x_at",0.832605695407954,0.408864544136458,-0.841854269466245,-5.60026525481599,-1.2512897453109,"PCDHB3","protocadherin beta 3",TRUE
+"221410_x_at",0.883114005048829,0.540821476564738,-0.621177401434493,-5.75347218184457,-0.618884762241772,"PCDHB3","protocadherin beta 3",TRUE
+"240317_at",0.617775129514679,0.0888669665044892,-1.77957796695113,-4.50474623994853,-1.81459555415073,"PCDHB4","protocadherin beta 4",TRUE
+"231750_at",0.932269331146744,0.701477780639744,-0.388330338669307,-5.86649986177695,-0.421790888135122,"PCDHB4","protocadherin beta 4",TRUE
+"223629_at",0.986260660718739,0.932611110632366,-0.085526328350811,-5.93612136224135,-0.177765534149387,"PCDHB5","protocadherin beta 5",TRUE
+"239443_at",0.85198620878286,0.457119623861824,0.7568386873556,-5.66447728926315,1.09424296335944,"PCDHB6","protocadherin beta 6",TRUE
+"221317_x_at",0.988164716416515,0.943595641141104,0.0715580304051141,-5.9371897565238,0.0637474461885903,"PCDHB6","protocadherin beta 6",TRUE
+"231738_at",0.675118548055585,0.141262227751402,1.52558396780418,-4.86552564565693,1.53346025529867,"PCDHB7","protocadherin beta 7",TRUE
+"221319_at",0.98539961718117,0.928370987308058,0.0909227229244532,-5.93565776032277,0.0879222919445022,"PCDHB8","protocadherin beta 8",TRUE
+"223927_at",0.822010986888098,0.385829271240985,-0.88467994006683,-5.56550383456329,-0.584178866725771,"PCDHB9","protocadherin beta 9",TRUE
+"223854_at",0.804439391353785,0.343168621196812,-0.968664013954841,-5.49271771108719,-0.852188420573162,"PCDHB9///PCDHB10","protocadherin beta 9///protocadherin beta 10",TRUE
+"211880_x_at",0.987360737469712,0.940715053246863,-0.0752195559315002,-5.93692806222264,-0.0272536724798247,"PCDHGA1","protocadherin gamma subfamily A, 1",TRUE
+"209079_x_at",0.934447550624693,0.709397462554307,0.377495210729877,-5.87051304391431,0.232746043349374,"PCDHGA1///PCDHGA2///PCDHGA3///PCDHGA4///PCDHGA5///PCDHGA6///PCDHGA7///PCDHGA9///PCDHGA10///PCDHGA11///PCDHGB1///PCDHGB2///PCDHGB3///PCDHGB5///PCDHGB6///PCDHGB7///PCDHGC4///PCDHGC5///PCDHGA12///PCDHGA8///PCDHGB4///PCDHGC3","protocadherin gamma subfamily A, 1///protocadherin gamma subfamily A, 2///protocadherin gamma subfamily A, 3///protocadherin gamma subfamily A, 4///protocadherin gamma subfamily A, 5///protocadherin gamma subfamily A, 6///protocadherin gamma subfamily A, 7///protocadherin gamma subfamily A, 9///protocadherin gamma subfamily A, 10///protocadherin gamma subfamily A, 11///protocadherin gamma subfamily B, 1///protocadherin gamma subfamily B, 2///protocadherin gamma subfamily B, 3///protocadherin gamma subfamily B, 5///protocadherin gamma subfamily B, 6///protocadherin gamma subfamily B, 7///protocadherin gamma subfamily C, 4///protocadherin gamma subfamily C, 5///protocadherin gamma subfamily A, 12///protocadherin gamma subfamily A, 8///protocadherin gamma subfamily B, 4///protocadherin gamma subfamily C, 3",TRUE
+"215836_s_at",0.940227139261806,0.732232075649644,0.346505314013049,-5.88137239339999,0.190620826659968,"PCDHGA1///PCDHGA2///PCDHGA3///PCDHGA4///PCDHGA5///PCDHGA6///PCDHGA7///PCDHGA9///PCDHGA10///PCDHGA11///PCDHGB1///PCDHGB2///PCDHGB3///PCDHGB5///PCDHGB6///PCDHGB7///PCDHGC4///PCDHGC5///PCDHGA12///PCDHGA8///PCDHGB4///PCDHGC3","protocadherin gamma subfamily A, 1///protocadherin gamma subfamily A, 2///protocadherin gamma subfamily A, 3///protocadherin gamma subfamily A, 4///protocadherin gamma subfamily A, 5///protocadherin gamma subfamily A, 6///protocadherin gamma subfamily A, 7///protocadherin gamma subfamily A, 9///protocadherin gamma subfamily A, 10///protocadherin gamma subfamily A, 11///protocadherin gamma subfamily B, 1///protocadherin gamma subfamily B, 2///protocadherin gamma subfamily B, 3///protocadherin gamma subfamily B, 5///protocadherin gamma subfamily B, 6///protocadherin gamma subfamily B, 7///protocadherin gamma subfamily C, 4///protocadherin gamma subfamily C, 5///protocadherin gamma subfamily A, 12///protocadherin gamma subfamily A, 8///protocadherin gamma subfamily B, 4///protocadherin gamma subfamily C, 3",TRUE
+"205717_x_at",0.940323871449272,0.733229142195388,0.345160219801455,-5.88182293704839,0.182776486177294,"PCDHGA1///PCDHGA2///PCDHGA3///PCDHGA4///PCDHGA5///PCDHGA6///PCDHGA7///PCDHGA9///PCDHGA10///PCDHGA11///PCDHGB1///PCDHGB2///PCDHGB3///PCDHGB5///PCDHGB6///PCDHGB7///PCDHGC4///PCDHGC5///PCDHGA12///PCDHGA8///PCDHGB4///PCDHGC3","protocadherin gamma subfamily A, 1///protocadherin gamma subfamily A, 2///protocadherin gamma subfamily A, 3///protocadherin gamma subfamily A, 4///protocadherin gamma subfamily A, 5///protocadherin gamma subfamily A, 6///protocadherin gamma subfamily A, 7///protocadherin gamma subfamily A, 9///protocadherin gamma subfamily A, 10///protocadherin gamma subfamily A, 11///protocadherin gamma subfamily B, 1///protocadherin gamma subfamily B, 2///protocadherin gamma subfamily B, 3///protocadherin gamma subfamily B, 5///protocadherin gamma subfamily B, 6///protocadherin gamma subfamily B, 7///protocadherin gamma subfamily C, 4///protocadherin gamma subfamily C, 5///protocadherin gamma subfamily A, 12///protocadherin gamma subfamily A, 8///protocadherin gamma subfamily B, 4///protocadherin gamma subfamily C, 3",TRUE
+"211066_x_at",0.98529096111871,0.926694612214007,0.0930569955346665,-5.93546658670002,0.0548370797894915,"PCDHGA1///PCDHGA2///PCDHGA3///PCDHGA4///PCDHGA5///PCDHGA6///PCDHGA7///PCDHGA9///PCDHGA10///PCDHGA11///PCDHGB1///PCDHGB2///PCDHGB3///PCDHGB5///PCDHGB6///PCDHGB7///PCDHGC4///PCDHGC5///PCDHGA12///PCDHGA8///PCDHGB4///PCDHGC3","protocadherin gamma subfamily A, 1///protocadherin gamma subfamily A, 2///protocadherin gamma subfamily A, 3///protocadherin gamma subfamily A, 4///protocadherin gamma subfamily A, 5///protocadherin gamma subfamily A, 6///protocadherin gamma subfamily A, 7///protocadherin gamma subfamily A, 9///protocadherin gamma subfamily A, 10///protocadherin gamma subfamily A, 11///protocadherin gamma subfamily B, 1///protocadherin gamma subfamily B, 2///protocadherin gamma subfamily B, 3///protocadherin gamma subfamily B, 5///protocadherin gamma subfamily B, 6///protocadherin gamma subfamily B, 7///protocadherin gamma subfamily C, 4///protocadherin gamma subfamily C, 5///protocadherin gamma subfamily A, 12///protocadherin gamma subfamily A, 8///protocadherin gamma subfamily B, 4///protocadherin gamma subfamily C, 3",TRUE
+"211875_x_at",0.914588178928864,0.640222663405528,0.47387875730682,-5.83089599391583,0.222233815449798,"PCDHGA10","protocadherin gamma subfamily A, 10",TRUE
+"211877_s_at",0.808605089946517,0.351632100241808,-0.951466846290277,-5.50811502205158,-0.601719758839205,"PCDHGA11///PCDHGC3","protocadherin gamma subfamily A, 11///protocadherin gamma subfamily C, 3",TRUE
+"216352_x_at",0.67606695078322,0.142546040941937,-1.52043042967591,-4.87239799185826,-0.605505102096163,"PCDHGA3","protocadherin gamma subfamily A, 3",TRUE
+"211879_x_at",0.885029460971826,0.546090074827812,0.61304259423138,-5.75827412291195,0.502778523859443,"PCDHGA3","protocadherin gamma subfamily A, 3",TRUE
+"211876_x_at",0.752235383514782,0.245529791948802,-1.19289227575717,-5.26938970459858,-1.01659228112351,"PCDHGA3///PCDHGA5///PCDHGA6///PCDHGA10///PCDHGA11///PCDHGA12///PCDHGC3","protocadherin gamma subfamily A, 3///protocadherin gamma subfamily A, 5///protocadherin gamma subfamily A, 6///protocadherin gamma subfamily A, 10///protocadherin gamma subfamily A, 11///protocadherin gamma subfamily A, 12///protocadherin gamma subfamily C, 3",TRUE
+"1552735_at",0.755345385769974,0.249258879918121,1.18322943829022,-5.2798576538713,1.08588677184998,"PCDHGA4","protocadherin gamma subfamily A, 4",TRUE
+"210368_at",0.970540753946729,0.85975150310586,-0.17875889557434,-5.92413147789589,-0.151064179923834,"PCDHGA8","protocadherin gamma subfamily A, 8",TRUE
+"211873_s_at",0.98693003519805,0.939799951306417,-0.0763829633969651,-5.93684218000447,-0.0336354234239375,"PCDHGA9","protocadherin gamma subfamily A, 9",TRUE
+"211807_x_at",0.871744769522775,0.513998898774458,0.663271510074581,-5.72765222656186,0.229700389483308,"PCDHGB5","protocadherin gamma subfamily B, 5",TRUE
+"221682_s_at",0.783140572788744,0.305636095878669,1.04866732210677,-5.41779911195515,0.940822941037386,"PCDHGB6","protocadherin gamma subfamily B, 6",TRUE
+"1552661_at",0.67368843181164,0.140241228187981,-1.52971003687426,-4.86001011460021,-2.08308722364684,"PCDHGB7","protocadherin gamma subfamily B, 7",TRUE
+"1552662_a_at",0.913160385122315,0.635657029976294,-0.480392987742987,-5.82790112647112,-0.368895060323918,"PCDHGB7","protocadherin gamma subfamily B, 7",TRUE
+"234029_at",0.857903028711331,0.47353736631878,0.729167400499397,-5.68398510815364,0.381977684393724,"PCDHGB8P","protocadherin gamma subfamily B, 8 pseudogene",TRUE
+"214564_s_at",0.886940491679955,0.550661238598273,0.606018278993333,-5.76237142529173,0.256073105962055,"PCDHGC3","protocadherin gamma subfamily C, 3",TRUE
+"214563_at",0.93854300027374,0.726570382494146,0.354155685957896,-5.8787769412511,0.280614152377169,"PCDHGC3","protocadherin gamma subfamily C, 3",TRUE
+"231753_s_at",0.55937703282623,0.0532328267278522,2.04199826199345,-4.09027800692681,1.28970892264787,"PCDHGC4","protocadherin gamma subfamily C, 4",TRUE
+"231754_at",0.778031107955451,0.297396873662521,1.06714420575361,-5.39973565306298,0.739159377500339,"PCDHGC4","protocadherin gamma subfamily C, 4",TRUE
+"224537_at",0.94895689004559,0.76814209497222,-0.298448178868554,-5.89639300292761,-0.173158656067972,"PCDHGC5","protocadherin gamma subfamily C, 5",TRUE
+"224536_s_at",0.82653010859268,0.394708754190304,0.867981328742124,-5.57924878331116,0.310980600710725,"PCDHGC5///PCDHGC3","protocadherin gamma subfamily C, 5///protocadherin gamma subfamily C, 3",TRUE
+"225505_s_at",0.725143559947316,0.203305452774255,-1.31093357530629,-5.13560807545062,-0.598739793017977,"PCED1A","PC-esterase domain containing 1A",TRUE
+"231965_at",0.962125056232529,0.828015824729568,-0.219830591571889,-5.91617328922391,-0.101610991434806,"PCED1A","PC-esterase domain containing 1A",TRUE
+"228298_at",0.726636642789909,0.205781150734369,1.30351630722353,-5.14433123193284,1.3537435136615,"PCED1B","PC-esterase domain containing 1B",TRUE
+"241947_at",0.959931948475729,0.818714302462623,-0.231938847521168,-5.91351552760564,-0.0993354008261012,"PCED1B-AS1","PCED1B antisense RNA 1",TRUE
+"203378_at",0.709262252160459,0.182053707303519,-1.37769892926277,-5.05521911126116,-0.423897443735221,"PCF11","PCF11 cleavage and polyadenylation factor subunit",TRUE
+"227622_at",0.901797819916539,0.599811440234363,-0.532306835115044,-5.80260828991754,-0.2414893260678,"PCF11","PCF11 cleavage and polyadenylation factor subunit",TRUE
+"234515_at",0.527546822913581,0.0402146719205828,2.17933982391322,-3.85837060490399,1.54000962921906,"PCGEM1","PCGEM1, prostate-specific transcript (non-protein coding)",TRUE
+"234529_at",0.888830748858811,0.556078524547081,-0.597733345592815,-5.76714545998666,-0.392817479777564,"PCGEM1","PCGEM1, prostate-specific transcript (non-protein coding)",TRUE
+"210022_at",0.913782990161554,0.638538923227941,-0.476278676324247,-5.82979730338647,-0.182203468946836,"PCGF1","polycomb group ring finger 1",TRUE
+"210023_s_at",0.967940019753468,0.848813025827156,-0.192876108958242,-5.92158037735806,-0.0561956882070387,"PCGF1","polycomb group ring finger 1",TRUE
+"214239_x_at",0.7995040428866,0.335011752526505,-0.985514463129619,-5.47738676449124,-0.519867989857106,"PCGF2","polycomb group ring finger 2",TRUE
+"203792_x_at",0.816800680706682,0.368301402569273,-0.918396542508704,-5.53701262470225,-0.568839703218117,"PCGF2","polycomb group ring finger 2",TRUE
+"213551_x_at",0.864262241343417,0.491542728062458,-0.699460793205209,-5.70415884444293,-0.336908907048501,"PCGF2","polycomb group ring finger 2",TRUE
+"203793_x_at",0.908709061737317,0.62084268798857,-0.501677913440414,-5.81783699299185,-0.295295635065859,"PCGF2","polycomb group ring finger 2",TRUE
+"238084_at",0.500605801567359,0.0318538195455481,-2.2907339873753,-3.66346587952428,-1.43496829239758,"PCGF3","polycomb group ring finger 3",TRUE
+"212753_at",0.544172907409316,0.0464798807060175,-2.10891732546491,-3.97848591397561,-0.801481269478804,"PCGF3","polycomb group ring finger 3",TRUE
+"204564_at",0.686108994812404,0.154674270165262,-1.47352984279135,-4.93408356870693,-0.389144762103781,"PCGF3","polycomb group ring finger 3",TRUE
+"230408_at",0.976371465776674,0.887136050949963,0.143572227242265,-5.92964864033799,0.0579585963222691,"PCGF3","polycomb group ring finger 3",TRUE
+"229413_s_at",0.976589025744684,0.888590534619249,-0.141708926920167,-5.929907292112,-0.0482715104624063,"PCGF3","polycomb group ring finger 3",TRUE
+"229996_s_at",0.645213368083975,0.116437411825248,1.63377132741408,-4.71705053007007,1.19038362159041,"PCGF5","polycomb group ring finger 5",TRUE
+"227935_s_at",0.691295036264984,0.160899407299118,1.45060891544838,-4.96366205051227,0.695054529460862,"PCGF5","polycomb group ring finger 5",TRUE
+"226326_at",0.761261833217751,0.260339712071431,1.15513851552484,-5.30986611112755,0.847519556419938,"PCGF5","polycomb group ring finger 5",TRUE
+"229194_at",0.855405088766616,0.468090513782717,0.738283773534133,-5.6776343116476,0.503274853699747,"PCGF5","polycomb group ring finger 5",TRUE
+"235331_x_at",0.888686718625571,0.555049569205181,0.59930371951396,-5.76624543667309,0.425256774239567,"PCGF5","polycomb group ring finger 5",TRUE
+"224326_s_at",0.854763246850622,0.466588097041379,0.740809382246358,-5.67586163736091,0.259164826307991,"PCGF6","polycomb group ring finger 6",TRUE
+"219940_s_at",0.500388308784901,0.0318056496038646,2.2914498837957,-3.66219461333359,0.80151264452768,"PCID2","PCI domain containing 2",TRUE
+"225149_at",0.585036027492332,0.0654419320088061,1.9382199451191,-4.25889297576597,0.848486148372723,"PCID2","PCI domain containing 2",TRUE
+"89948_at",0.734730148360473,0.219387387855226,-1.26394124984716,-5.19016202462035,-0.34123130527894,"PCIF1","PDX1 C-terminal inhibiting factor 1",TRUE
+"222045_s_at",0.885929137203218,0.548068900535192,-0.609998019637229,-5.76005562469255,-0.199164635484792,"PCIF1","PDX1 C-terminal inhibiting factor 1",TRUE
+"221762_s_at",0.910967291330762,0.628638090908721,-0.49044899339589,-5.82319947027112,-0.189833901482087,"PCIF1","PDX1 C-terminal inhibiting factor 1",TRUE
+"208383_s_at",0.839466826665106,0.425814164878232,-0.811316277746803,-5.62406871292023,-0.438629084895745,"PCK1","phosphoenolpyruvate carboxykinase 1",TRUE
+"202847_at",0.854184492233394,0.464198825709231,-0.744835779711857,-5.6730237202996,-0.378323785005774,"PCK2","phosphoenolpyruvate carboxykinase 2, mitochondrial",TRUE
+"217096_at",0.723655063748891,0.20067385163023,-1.31889540279537,-5.12619793451524,-0.875618254616309,"PCLO","piccolo presynaptic cytomatrix protein",TRUE
+"210650_s_at",0.934081042629428,0.708198286364487,0.379132849799385,-5.86991366835165,0.304064539375408,"PCLO","piccolo presynaptic cytomatrix protein",TRUE
+"213558_at",0.943631120237335,0.74792697343266,0.325405724987773,-5.88824010080442,0.189693583291561,"PCLO","piccolo presynaptic cytomatrix protein",TRUE
+"228905_at",0.926735112907652,0.680854255854581,-0.416773404628267,-5.85543288828218,-0.442732969641509,"PCM1","pericentriolar material 1",TRUE
+"214118_x_at",0.940756067985891,0.734837105708633,0.342992359723566,-5.88254542273331,0.129801037640265,"PCM1","pericentriolar material 1",TRUE
+"202174_s_at",0.952041062962677,0.780509218635932,-0.282068106216403,-5.90100568659866,-0.12534434482459,"PCM1","pericentriolar material 1",TRUE
+"209996_x_at",0.967777603239069,0.848444533479588,-0.19335236824665,-5.92149094535043,-0.164071140601519,"PCM1","pericentriolar material 1",TRUE
+"214937_x_at",0.983777183253528,0.920626450251121,-0.10078643936761,-5.9347371498691,-0.0352230626123706,"PCM1","pericentriolar material 1",TRUE
+"209997_x_at",0.988765741729843,0.945909922570227,-0.0686170674972286,-5.93739050063307,-0.0231923095334388,"PCM1","pericentriolar material 1",TRUE
+"208857_s_at",0.727822268767891,0.208003386036223,-1.29691720450775,-5.15205691565063,-0.395891845750691,"PCMT1","protein-L-isoaspartate (D-aspartate) O-methyltransferase",TRUE
+"205202_at",0.760439386481756,0.25936546836121,-1.15757232446792,-5.30729117240896,-0.378998496689759,"PCMT1","protein-L-isoaspartate (D-aspartate) O-methyltransferase",TRUE
+"210156_s_at",0.930499673921727,0.692488074470247,-0.40068709216968,-5.86178652717298,-0.134599515367634,"PCMT1","protein-L-isoaspartate (D-aspartate) O-methyltransferase",TRUE
+"244706_at",0.844509386281136,0.441353657130264,-0.7839787845456,-5.6446768920622,-0.575855281794107,"PCMTD1","protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1",TRUE
+"226119_at",0.916107385524794,0.646146325501564,-0.465457746477553,-5.83470818191265,-0.274575503159056,"PCMTD1","protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1",TRUE
+"238114_at",0.924812035112346,0.674633428161939,0.425420905833735,-5.85191574651573,0.141639277217371,"PCMTD1","protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1",TRUE
+"232382_s_at",0.930899509890345,0.694063116226447,-0.398517589633412,-5.86262458141164,-0.228459092987977,"PCMTD1","protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1",TRUE
+"235507_at",0.946249475978621,0.756285897446018,-0.314230132446697,-5.89170468837794,-0.164830552339838,"PCMTD1","protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1",TRUE
+"237179_at",0.764430688544079,0.264460496645361,1.14491797769489,-5.320627295528,0.549122560686883,"PCMTD2","protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2",TRUE
+"212406_s_at",0.772943317221533,0.283426317340233,-1.09932939959502,-5.36759766096856,-0.426324128189387,"PCMTD2","protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2",TRUE
+"201202_at",0.785440072877511,0.310972496709273,-1.03688796392684,-5.42916687545346,-0.337605117971476,"PCNA","proliferating cell nuclear antigen",TRUE
+"1554868_s_at",0.855449962008039,0.46865127368394,-0.737342349430217,-5.67829360913893,-0.235405349283887,"PCNP","PEST proteolytic signal containing nuclear protein",TRUE
+"217816_s_at",0.859675188316647,0.47784890074314,-0.721994842592021,-5.68892907940577,-0.19929788110678,"PCNP","PEST proteolytic signal containing nuclear protein",TRUE
+"237577_at",0.997039490727282,0.984871808385983,-0.0191766766739718,-5.93950436734048,-0.0178202667121812,"PCNP","PEST proteolytic signal containing nuclear protein",TRUE
+"203660_s_at",0.954577684533304,0.792929975216153,-0.265695942094926,-5.90535795618664,-0.0841654431027674,"PCNT","pericentrin",TRUE
+"233387_s_at",0.986342822130003,0.933759349070633,-0.0840654226014628,-5.93624199400501,-0.0572861507040265,"PCNT","pericentrin",TRUE
+"215175_at",0.611042853196665,0.0834209287197416,-1.81288921261187,-4.45436730517799,-0.771058590161899,"PCNX1","pecanex homolog 1 (Drosophila)",TRUE
+"213159_at",0.629618998226163,0.100586923628452,-1.71346055980287,-4.60270154754772,-0.737366698496078,"PCNX1","pecanex homolog 1 (Drosophila)",TRUE
+"239100_x_at",0.720952283360079,0.197063029252456,1.32995346915822,-5.11304863571544,0.62526179781071,"PCNX1","pecanex homolog 1 (Drosophila)",TRUE
+"235082_at",0.739189560382301,0.226209727836153,1.24480444489827,-5.21189024328276,1.17704769757794,"PCNX1","pecanex homolog 1 (Drosophila)",TRUE
+"213173_at",0.780237570670818,0.301670817756353,-1.05751482981282,-5.40918488141349,-0.274162559778679,"PCNX1","pecanex homolog 1 (Drosophila)",TRUE
+"238792_at",0.908882763411412,0.621546296617706,-0.500661730886614,-5.81832715770913,-0.157709399444971,"PCNX1","pecanex homolog 1 (Drosophila)",TRUE
+"229287_at",0.976371465776674,0.887123462654149,-0.143588356035344,-5.9296463867184,-0.0523430162734568,"PCNX1","pecanex homolog 1 (Drosophila)",TRUE
+"205689_at",0.744573608322482,0.235893895788589,1.21838151792544,-5.24142187024577,0.917163455027906,"PCNX2","pecanex homolog 2 (Drosophila)",TRUE
+"39650_s_at",0.786455312223125,0.312246201612687,1.03409756613257,-5.43184282890883,0.413835470641224,"PCNX2","pecanex homolog 2 (Drosophila)",TRUE
+"1554256_a_at",0.812302873476553,0.357934868185312,0.938841430667982,-5.51925819216511,0.781573621170425,"PCNX2","pecanex homolog 2 (Drosophila)",TRUE
+"229202_at",0.813442508625161,0.363708044758995,0.927407444718947,-5.52923183308587,0.462285945921256,"PCNX2","pecanex homolog 2 (Drosophila)",TRUE
+"220461_at",0.910165867297668,0.626231037114787,-0.493909359159039,-5.82155957695663,-0.240795121514962,"PCNX2","pecanex homolog 2 (Drosophila)",TRUE
+"227858_at",0.946277807642742,0.756703388763274,-0.313673042153056,-5.89187425664942,-0.209076051769211,"PCNX3","pecanex homolog 3 (Drosophila)",TRUE
+"235188_at",0.740610299769501,0.230002863792652,-1.23435450782145,-5.2236349419376,-0.931248363098891,"PCNX4","pecanex homolog 4 (Drosophila)",TRUE
+"201789_at",0.901910595357431,0.600105531256543,0.531875030944142,-5.80282908876561,0.497518259433654,"PCNX4","pecanex homolog 4 (Drosophila)",TRUE
+"1558568_a_at",0.925447069825085,0.676968551580325,-0.422171045566099,-5.85324586831081,-0.123608392928742,"PCNX4","pecanex homolog 4 (Drosophila)",TRUE
+"236015_at",0.925511384407886,0.678015724704756,0.42071516590113,-5.8538384874681,0.220174699712067,"PCNX4","pecanex homolog 4 (Drosophila)",TRUE
+"219972_s_at",0.934283509040375,0.70905681430385,-0.37796030540666,-5.87034307954059,-0.165268441547687,"PCNX4","pecanex homolog 4 (Drosophila)",TRUE
+"1568971_at",0.975242094553739,0.879914647778559,0.152831221956947,-5.9283133603107,0.104783163154538,"PCNX4","pecanex homolog 4 (Drosophila)",TRUE
+"235187_s_at",0.983025552039093,0.917508494670452,-0.104760415600417,-5.93433950056554,-0.0859343235459376,"PCNX4","pecanex homolog 4 (Drosophila)",TRUE
+"202465_at",0.702185342714694,0.17366811730445,-1.40574610726282,-5.02045863524192,-1.46681244888225,"PCOLCE","procollagen C-endopeptidase enhancer",TRUE
+"1560939_at",0.691295036264984,0.161012637356924,1.45019869357167,-4.96418799319797,0.430799548772837,"PCOLCE-AS1","PCOLCE antisense RNA 1",TRUE
+"219295_s_at",0.646224068018448,0.1172008753264,1.63016947056112,-4.72212072555965,2.30077904126768,"PCOLCE2","procollagen C-endopeptidase enhancer 2",TRUE
+"1560178_at",0.755483862926893,0.24950657728159,1.18259144193502,-5.28054619518559,0.602440729196024,"PCP2","Purkinje cell protein 2",TRUE
+"244751_at",0.956398858120188,0.802047806113853,0.253724766824672,-5.9083767307695,0.180965753515519,"PCP2","Purkinje cell protein 2",TRUE
+"205549_at",0.683019114815084,0.152059025134432,-1.48338283637302,-4.92125347147158,-2.25559070990034,"PCP4","Purkinje cell protein 4",TRUE
+"241382_at",0.959500955478966,0.816966584003883,-0.234217846007574,-5.91299943774798,-0.120686332455823,"PCP4L1","Purkinje cell protein 4 like 1",TRUE
+"205825_at",0.815217400146643,0.366222008036696,0.92246640241618,-5.53350701816933,0.86854514383351,"PCSK1","proprotein convertase subtilisin/kexin type 1",TRUE
+"218952_at",0.964685626382167,0.836763467131283,0.208473969425128,-5.91853717995651,0.194291640846336,"PCSK1N","proprotein convertase subtilisin/kexin type 1 inhibitor",TRUE
+"204870_s_at",0.841967750949524,0.434790845541704,-0.795450534279591,-5.63610987709349,-0.625608737659355,"PCSK2","proprotein convertase subtilisin/kexin type 2",TRUE
+"204869_at",0.87825255145971,0.530303210390705,-0.637545734887884,-5.74362535812034,-0.381227991468392,"PCSK2","proprotein convertase subtilisin/kexin type 2",TRUE
+"230901_x_at",0.992406209985304,0.964653323015619,0.044818677146447,-5.93870515766609,0.0124685768457686,"PCSK4","proprotein convertase subtilisin/kexin type 4",TRUE
+"205559_s_at",0.694819513561858,0.164236272936391,1.43861622279392,-4.97898775934526,1.82663756126766,"PCSK5","proprotein convertase subtilisin/kexin type 5",TRUE
+"205560_at",0.705650323866416,0.177732247095828,1.39202141121848,-5.03754085529619,1.29030975530754,"PCSK5","proprotein convertase subtilisin/kexin type 5",TRUE
+"213652_at",0.744307803443383,0.235277410256544,1.22003880907729,-5.23958568254027,1.64645258954576,"PCSK5","proprotein convertase subtilisin/kexin type 5",TRUE
+"242662_at",0.571736836402345,0.0597699409084591,1.9840842509509,-4.18510477122753,1.33577052245475,"PCSK6","proprotein convertase subtilisin/kexin type 6",TRUE
+"211262_at",0.741877580525799,0.2324323496993,1.22773002457981,-5.23103600037732,0.67648545909134,"PCSK6","proprotein convertase subtilisin/kexin type 6",TRUE
+"211263_s_at",0.782876787164404,0.305262752414617,1.0494968563986,-5.41699421123503,0.574236110428709,"PCSK6","proprotein convertase subtilisin/kexin type 6",TRUE
+"1553531_at",0.867461563651579,0.500057678338737,0.685630561410973,-5.71327797140474,0.616257568915957,"PCSK6","proprotein convertase subtilisin/kexin type 6",TRUE
+"203118_at",0.728385463227073,0.209310973382638,-1.2930597208271,-5.15655752739247,-0.614275075857837,"PCSK7","proprotein convertase subtilisin/kexin type 7",TRUE
+"232521_at",0.936992192746977,0.718972519293922,0.364456363474928,-5.87519391530113,0.265131446708002,"PCSK7","proprotein convertase subtilisin/kexin type 7",TRUE
+"227759_at",0.303059342222774,0.00584217742025558,3.04986327190503,-2.20679697743184,2.22410294552972,"PCSK9","proprotein convertase subtilisin/kexin type 9",TRUE
+"218676_s_at",0.968451827985008,0.852006121943309,0.188751078544219,-5.92234578018916,0.128759870704092,"PCTP","phosphatidylcholine transfer protein",TRUE
+"203803_at",0.632216562924782,0.103416590088568,1.69848907834889,-4.62449848218683,0.50533921575129,"PCYOX1","prenylcysteine oxidase 1",TRUE
+"225274_at",0.814108236077364,0.365042112769504,0.924782585691468,-5.53150558221433,0.273907526717258,"PCYOX1","prenylcysteine oxidase 1",TRUE
+"218953_s_at",0.83891147088821,0.424311985659672,-0.813991548833796,-5.62201634762618,-0.588449703707916,"PCYOX1L","prenylcysteine oxidase 1 like",TRUE
+"204209_at",0.683019114815084,0.152046873972036,1.4834289366048,-4.92119327986962,0.462777386431027,"PCYT1A","phosphate cytidylyltransferase 1, choline, alpha",TRUE
+"204210_s_at",0.697172073261335,0.167131399125322,1.42836905496561,-4.99200047686444,0.577088817661419,"PCYT1A","phosphate cytidylyltransferase 1, choline, alpha",TRUE
+"225069_at",0.936456142259101,0.716476386668758,0.367849185348105,-5.87399153972812,0.141201437905943,"PCYT1A","phosphate cytidylyltransferase 1, choline, alpha",TRUE
+"206751_s_at",0.641547541078628,0.111996648011537,1.65512430265077,-4.68681664484748,1.54779410023741,"PCYT1B","phosphate cytidylyltransferase 1, choline, beta",TRUE
+"232553_at",0.709914655587487,0.182873417201586,1.37501269253591,-5.05851783521667,0.9542697129144,"PCYT1B","phosphate cytidylyltransferase 1, choline, beta",TRUE
+"210456_at",0.884803041417939,0.544815348740308,0.615006953231556,-5.75712015881101,0.402405639443915,"PCYT1B","phosphate cytidylyltransferase 1, choline, beta",TRUE
+"209577_at",0.677509122383198,0.145057885419447,-1.51045639166531,-4.88564587175577,-0.501894340609653,"PCYT2","phosphate cytidylyltransferase 2, ethanolamine",TRUE
+"230044_at",0.989545686833247,0.949022727659591,0.0646623226205566,-5.9376471697953,0.0439088091346527,"PCYT2","phosphate cytidylyltransferase 2, ethanolamine",TRUE
+"217624_at",0.855439520086837,0.468569695328567,0.73747926469034,-5.67819777433245,0.95150096476898,"PDAP1","PDGFA associated protein 1",TRUE
+"202290_at",0.944329402768066,0.750472005115231,-0.321998693626728,-5.88930902883269,-0.127391763691474,"PDAP1","PDGFA associated protein 1",TRUE
+"211496_s_at",0.894729774938685,0.571951304016689,-0.573696434903557,-5.78063657452238,-0.434124453174682,"PDC","phosducin",TRUE
+"207634_at",0.860085676417428,0.478789787065142,0.720434649403096,-5.68999835211762,0.541821697495546,"PDCD1","programmed cell death 1",TRUE
+"210907_s_at",0.641581234599539,0.112052294635409,1.65485235695851,-4.68720358284743,0.410292855252882,"PDCD10","programmed cell death 10",TRUE
+"212422_at",0.664177276170497,0.132240216340046,1.56293011940895,-4.81517370261804,0.510117934870571,"PDCD11","programmed cell death 11",TRUE
+"212424_at",0.999113817096968,0.997103711566457,-0.00367114332365395,-5.93967691645857,-0.00116615765228545,"PDCD11","programmed cell death 11",TRUE
+"220049_s_at",0.464344196869063,0.0238987575672527,2.42510219836647,-3.4209106957499,2.05735874381652,"PDCD1LG2","programmed cell death 1 ligand 2",TRUE
+"224399_at",0.473893167318731,0.0259330060854598,2.38720658434471,-3.49010377598937,1.93599161613537,"PDCD1LG2","programmed cell death 1 ligand 2",TRUE
+"213585_s_at",0.774230543658252,0.288337793889298,1.08788685922747,-5.37912097969054,0.411542565308252,"PDCD2","programmed cell death 2",TRUE
+"228420_at",0.80110325033185,0.337789675936519,-0.979744538211035,-5.48266350841327,-0.344465693338915,"PDCD2","programmed cell death 2",TRUE
+"243773_at",0.884122836669679,0.542834264954828,-0.618064663788078,-5.75531682329909,-0.206380132263663,"PDCD2","programmed cell death 2",TRUE
+"213581_at",0.942373096422033,0.741138971803932,0.334512188827818,-5.8853283730452,0.160557457843375,"PDCD2","programmed cell death 2",TRUE
+"204025_s_at",0.990810941805126,0.955269819754455,0.0567286623959221,-5.9381161644042,0.0260955197751684,"PDCD2","programmed cell death 2",TRUE
+"224467_s_at",0.937271400689562,0.72196161038126,-0.360399219920754,-5.87661727639284,-0.116767512772043,"PDCD2L","programmed cell death 2 like",TRUE
+"1557166_at",0.797041381178845,0.330066783146163,-0.995867594638304,-5.46784791799141,-0.92681891802267,"PDCD4","programmed cell death 4 (neoplastic transformation inhibitor)",TRUE
+"222307_at",0.468591857727704,0.0246788121160014,-2.41023023224843,-3.44813669879899,-1.87258528583323,"PDCD4-AS1","PDCD4 antisense RNA 1",TRUE
+"227751_at",0.96567534940972,0.839475323580465,0.204959061486156,-5.91924351481722,0.0890953574055819,"PDCD5","programmed cell death 5",TRUE
+"219275_at",0.986342822130003,0.93493853039195,0.0825653432121289,-5.93636369927861,0.0348043553239403,"PDCD5","programmed cell death 5",TRUE
+"222152_at",0.857750641191636,0.473318709640517,0.729532171173622,-5.68373243466797,0.475537465702815,"PDCD6","programmed cell death 6",TRUE
+"203415_at",0.906476756086155,0.614016802990394,0.511564206716492,-5.81301764968648,0.171755547296325,"PDCD6","programmed cell death 6",TRUE
+"222380_s_at",0.997803037376393,0.989134423882954,0.0137729071259985,-5.93959108871932,0.00784562980352099,"PDCD6","programmed cell death 6",TRUE
+"217746_s_at",0.951206799139251,0.776953716374208,-0.286769050534529,-5.89970830484888,-0.0897662045038281,"PDCD6IP","programmed cell death 6 interacting protein",TRUE
+"222394_at",0.961395512423249,0.824921579281337,-0.223854705009144,-5.91530572563535,-0.0896899150547537,"PDCD6IP","programmed cell death 6 interacting protein",TRUE
+"231809_x_at",0.384135218769668,0.0124698376166551,-2.71950994657884,-2.86445342073999,-0.840168387509602,"PDCD7","programmed cell death 7",TRUE
+"230182_at",0.801086839730802,0.337504075961574,-0.980336239990416,-5.48212368058877,-0.813265258365362,"PDCD7","programmed cell death 7",TRUE
+"204449_at",0.954577684533304,0.792731461541564,0.265957014151103,-5.90529058147555,0.0720150751165782,"PDCL","phosducin like",TRUE
+"204448_s_at",0.95915232180739,0.814798106376709,0.237047273610746,-5.91235171637273,0.0843654475345552,"PDCL","phosducin like",TRUE
+"237477_at",0.697172073261335,0.167512704872044,1.42703009331686,-4.99369517926325,1.36052312688252,"PDCL2","phosducin like 2",TRUE
+"219043_s_at",0.779229550249332,0.300412405873713,-1.06033992932748,-5.40642059222216,-0.373372883848061,"PDCL3P4///PDCL3","phosducin-like 3 pseudogene 4///phosducin like 3",TRUE
+"227968_at",0.987878312181854,0.942048497002854,0.0735244829464011,-5.93705083368935,0.028495560665414,"PDDC1","Parkinson disease 7 domain containing 1",TRUE
+"205501_at",0.592007267652348,0.0691243602504361,1.91028603493441,-4.30325275154725,2.16591113096421,"PDE10A","phosphodiesterase 10A",TRUE
+"211170_s_at",0.69805586360447,0.16902948459118,1.42172798999766,-5.00039317215522,0.771624210324763,"PDE10A","phosphodiesterase 10A",TRUE
+"211171_s_at",0.723973974120865,0.200883554887656,1.3182579783666,-5.12695308261452,0.86874367127627,"PDE10A","phosphodiesterase 10A",TRUE
+"221110_x_at",0.767727587789514,0.270100514764946,1.13111778788042,-5.33502378521793,0.313655663443035,"PDE11A","phosphodiesterase 11A",TRUE
+"237248_at",0.775351898377291,0.292094010875793,1.07923024750805,-5.38776727554919,0.711771005360172,"PDE11A","phosphodiesterase 11A",TRUE
+"224224_s_at",0.951632891935823,0.778050178972385,0.285318652262145,-5.90011085998256,0.160456068142114,"PDE11A","phosphodiesterase 11A",TRUE
+"224223_s_at",0.976422537443518,0.887842561385373,0.142667070934883,-5.92977470968711,0.08499794935054,"PDE11A","phosphodiesterase 11A",TRUE
+"235091_at",0.358427723880268,0.00991521765352689,-2.82062575629518,-2.66645990343381,-1.57885217201054,"PDE12","phosphodiesterase 12",TRUE
+"231839_at",0.508488499910913,0.0336726260400096,-2.26440273744759,-3.71006155778478,-0.920128569334683,"PDE12","phosphodiesterase 12",TRUE
+"1554915_a_at",0.70573152022539,0.178076866585071,-1.39086915699809,-5.03896868578127,-0.466670600105818,"PDE12","phosphodiesterase 12",TRUE
+"214826_at",0.959451355429682,0.816768058282872,0.234476800552844,-5.91294047869035,0.231946305928438,"PDE12","phosphodiesterase 12",TRUE
+"233547_x_at",0.686747966354964,0.155219276996928,-1.47149357567098,-4.93672648514633,-1.0170287869244,"PDE1A","phosphodiesterase 1A",TRUE
+"231213_at",0.837067957688307,0.419495987371305,-0.822608659735409,-5.61536257863508,-0.712128957683313,"PDE1A","phosphodiesterase 1A",TRUE
+"208396_s_at",0.852153111602676,0.457848190332697,0.75559827842654,-5.66536648963081,0.715568191702036,"PDE1A","phosphodiesterase 1A",TRUE
+"233549_at",0.860819742788118,0.480750102035428,0.717189759859622,-5.69221517855287,0.520309453350905,"PDE1A","phosphodiesterase 1A",TRUE
+"1558680_s_at",0.931370027472813,0.696464072132258,0.395214188952317,-5.8638920413861,0.285978961026523,"PDE1A","phosphodiesterase 1A",TRUE
+"242789_at",0.93667390723462,0.717240725239308,-0.366809806894314,-5.87436105156776,-0.331923122716383,"PDE1A","phosphodiesterase 1A",TRUE
+"236234_at",0.956619372543067,0.803145885754276,-0.252285641105339,-5.90873032511867,-0.206499450392785,"PDE1A","phosphodiesterase 1A",TRUE
+"206444_at",0.94895689004559,0.767626797725663,0.299132463106672,-5.89619468906681,0.191667728935451,"PDE1B","phosphodiesterase 1B",TRUE
+"207303_at",0.700061364939874,0.171423559304197,1.41343626474634,-5.01082682648277,0.771781215452692,"PDE1C","phosphodiesterase 1C",TRUE
+"236344_at",0.704130394289074,0.175932790423101,1.39806704495151,-5.03003331177755,1.24159045304395,"PDE1C","phosphodiesterase 1C",TRUE
+"239218_at",0.856874648266698,0.471505021274904,0.73256165872902,-5.68162929779109,1.15050411747466,"PDE1C","phosphodiesterase 1C",TRUE
+"1554378_a_at",0.860085676417428,0.479313476350336,0.7195670346156,-5.6905920169173,0.73697455984315,"PDE1C","phosphodiesterase 1C",TRUE
+"243564_at",0.89967769475675,0.591119623506382,-0.545115562209278,-5.79597943296161,-0.414195043962736,"PDE1C","phosphodiesterase 1C",TRUE
+"216869_at",0.910888708415045,0.62850889201764,-0.490634574429248,-5.8231118078723,-0.398659925726379,"PDE1C","phosphodiesterase 1C",TRUE
+"204134_at",0.97897951922649,0.898087817212376,0.129554519380827,-5.93151173635058,0.0896814828493513,"PDE2A","phosphodiesterase 2A",TRUE
+"206389_s_at",0.627021415091472,0.097604157552663,1.72963552736411,-4.5789918393672,1.52534211602861,"PDE3A","phosphodiesterase 3A",TRUE
+"228507_at",0.819018525257656,0.373490592558896,-0.908306257022581,-5.54564232312882,-0.994336301324374,"PDE3A","phosphodiesterase 3A",TRUE
+"206388_at",0.959389646649299,0.816450678901604,-0.234890820433863,-5.91284607955235,-0.120955307019269,"PDE3A","phosphodiesterase 3A",TRUE
+"236300_at",0.990810941805126,0.955740787688006,0.0561307019245196,-5.93814902902895,0.0452877198660921,"PDE3A","phosphodiesterase 3A",TRUE
+"214582_at",0.837368340567858,0.421011689207758,-0.819890006025607,-5.61746889821443,-0.509777755797215,"PDE3B","phosphodiesterase 3B",TRUE
+"222317_at",0.853297110808539,0.4601010581653,-0.751770164336692,-5.66810200967663,-0.939328377157485,"PDE3B","phosphodiesterase 3B",TRUE
+"208591_s_at",0.91876780831279,0.654800360459989,0.453216192729932,-5.84013050640591,0.184076711206233,"PDE3B","phosphodiesterase 3B",TRUE
+"242435_at",0.616413638398853,0.0873092196598216,1.78892205985964,-4.4906830651153,0.866265123790687,"PDE4A","phosphodiesterase 4A",TRUE
+"204735_at",0.697172073261335,0.167148881397264,1.42830761204871,-4.99207827268068,0.967603523833985,"PDE4A","phosphodiesterase 4A",TRUE
+"211901_s_at",0.765934384067577,0.266286793656008,1.14042584558631,-5.32533042268717,0.786099220087353,"PDE4A","phosphodiesterase 4A",TRUE
+"211591_s_at",0.905462783815257,0.61138515998961,-0.515389538860365,-5.811128280621,-0.249188501411783,"PDE4A","phosphodiesterase 4A",TRUE
+"211447_s_at",0.930558143410966,0.692808409431857,0.400245696441567,-5.86195739637624,0.405069083849216,"PDE4A","phosphodiesterase 4A",TRUE
+"215671_at",0.598790786356002,0.0757975497461342,1.86283307353549,-4.37757726520827,2.02946474383178,"PDE4B","phosphodiesterase 4B",TRUE
+"203708_at",0.901015420810252,0.597251932642132,-0.536069215594038,-5.80067705701334,-0.87240222149719,"PDE4B","phosphodiesterase 4B",TRUE
+"211302_s_at",0.998709719538178,0.9943567917408,0.00715300385446881,-5.93965855996869,0.00696063288654258,"PDE4B","phosphodiesterase 4B",TRUE
+"210837_s_at",0.750219698622305,0.24317134886117,1.19906039154342,-5.26266890435273,0.718121541380995,"PDE4D","phosphodiesterase 4D",TRUE
+"211840_s_at",0.754478661231213,0.247635276654316,1.18742314192159,-5.27532364399961,0.960872509383491,"PDE4D","phosphodiesterase 4D",TRUE
+"204491_at",0.88113080359582,0.537490093170406,0.626342958499031,-5.75039132139685,0.680423714208572,"PDE4D","phosphodiesterase 4D",TRUE
+"228962_at",0.91994485246627,0.659262805526909,-0.446931340533765,-5.84285930634472,-0.43155267419962,"PDE4D","phosphodiesterase 4D",TRUE
+"1554717_a_at",0.947969282616012,0.763505489622804,-0.304610596717963,-5.89459083061274,-0.223128647081457,"PDE4D","phosphodiesterase 4D",TRUE
+"210836_x_at",0.98687728101116,0.938655493605397,-0.0778381126948855,-5.93673290720293,-0.0687067323398054,"PDE4D","phosphodiesterase 4D",TRUE
+"210305_at",0.683861743647864,0.152882342800326,1.48026621264883,-4.92531925004124,1.58863524303085,"PDE4DIP","phosphodiesterase 4D interacting protein",TRUE
+"205872_x_at",0.771159692311272,0.280343707445788,1.10658459597393,-5.36023571661694,0.916291817394908,"PDE4DIP","phosphodiesterase 4D interacting protein",TRUE
+"215575_at",0.827985973549523,0.397609925549948,-0.862578241223747,-5.58364404638201,-0.702380199608665,"PDE4DIP","phosphodiesterase 4D interacting protein",TRUE
+"209700_x_at",0.902212740485572,0.600758142877048,0.530917188028637,-5.80331825002508,0.500346172897116,"PDE4DIP","phosphodiesterase 4D interacting protein",TRUE
+"1556787_s_at",0.71454754703986,0.189594967439691,1.3533375539605,-5.08493878098796,0.623886862100894,"PDE5A","phosphodiesterase 5A",TRUE
+"206757_at",0.836756831475262,0.418675480329482,-0.824082945634335,-5.61421762158961,-0.467842829535237,"PDE5A","phosphodiesterase 5A",TRUE
+"1553175_s_at",0.860714927752408,0.480527909223837,-0.717557165405265,-5.69196465432924,-0.462393623822885,"PDE5A","phosphodiesterase 5A",TRUE
+"1556786_at",0.874162829001327,0.520015613172221,0.653726476157696,-5.73364948892576,0.552704314853925,"PDE5A","phosphodiesterase 5A",TRUE
+"227088_at",0.898405288322584,0.587715705750334,-0.55015688160111,-5.79332841110962,-0.434357423457529,"PDE5A","phosphodiesterase 5A",TRUE
+"240088_at",0.913462631455429,0.637059782350745,-0.478389313424017,-5.82882655958813,-0.173369304562735,"PDE5A","phosphodiesterase 5A",TRUE
+"1562227_at",0.913782990161554,0.638520198641407,0.476305381349179,-5.82978504719275,0.236315688055847,"PDE5A","phosphodiesterase 5A",TRUE
+"1562228_s_at",0.918047479325634,0.652037983110973,0.457115984599552,-5.83841848686507,0.160159220072979,"PDE5A","phosphodiesterase 5A",TRUE
+"206623_at",0.91671872326659,0.648116364844445,-0.462664743704613,-5.83595779181208,-0.250466867860781,"PDE6A","phosphodiesterase 6A",TRUE
+"210304_at",0.861962516141708,0.484615607670432,0.710813708740218,-5.69654338974693,0.529954751989162,"PDE6B","phosphodiesterase 6B",TRUE
+"1557777_at",0.94740898733987,0.760648168464804,0.308414193195224,-5.89346026714061,0.261070992098856,"PDE6B","phosphodiesterase 6B",TRUE
+"211093_at",0.774230543658252,0.287525233482182,-1.08977016177059,-5.3772317644814,-0.741707425232339,"PDE6C","phosphodiesterase 6C",TRUE
+"204091_at",0.245492559900582,0.00332876893916561,-3.28868135845165,-1.71477744947378,-0.992890901838283,"PDE6D","phosphodiesterase 6D",TRUE
+"216883_x_at",0.480603497646452,0.0270886685654495,-2.36688460618067,-3.52695977279162,-0.713871940108495,"PDE6D","phosphodiesterase 6D",TRUE
+"231065_at",0.970540753946729,0.859843208846605,-0.17864070112608,-5.92415202110988,-0.0604965752105979,"PDE6D","phosphodiesterase 6D",TRUE
+"210060_at",0.907111393934291,0.615757334695515,0.50903843085379,-5.81425763233894,0.185836986005829,"PDE6G","phosphodiesterase 6G",TRUE
+"206841_at",0.96351240321323,0.833840125102515,0.212266002116096,-5.91776174475553,0.153213746842895,"PDE6H","phosphodiesterase 6H",TRUE
+"230444_at",0.467673691528294,0.0245710227000781,-2.41225913776418,-3.44442780249833,-1.30990667375615,"PDE7A","phosphodiesterase 7A",TRUE
+"223359_s_at",0.746845790319172,0.23885405559252,-1.21046902595468,-5.25015868009479,-0.591304655413917,"PDE7A","phosphodiesterase 7A",TRUE
+"223358_s_at",0.76029267756668,0.258827422888327,-1.15891934527008,-5.30586399663808,-0.79624792309488,"PDE7A","phosphodiesterase 7A",TRUE
+"224046_s_at",0.789927874973432,0.319114953862835,-1.01918604212141,-5.44603245443574,-0.611855537398647,"PDE7A","phosphodiesterase 7A",TRUE
+"230500_at",0.812302873476553,0.358038355297229,0.938635385154938,-5.51943891489772,0.313827411321439,"PDE7A","phosphodiesterase 7A",TRUE
+"1552343_s_at",0.946941640414848,0.759233300244457,0.31029934814169,-5.89289478006475,0.177694365744379,"PDE7A","phosphodiesterase 7A",TRUE
+"230109_at",0.522667179791589,0.0385353586444344,2.19990164624551,-3.82283738711085,2.36652946559568,"PDE7B","phosphodiesterase 7B",TRUE
+"243438_at",0.610404195568275,0.0828241868274555,1.81665260537135,-4.44863315841935,1.47537563227324,"PDE7B","phosphodiesterase 7B",TRUE
+"220343_at",0.82157450493276,0.3841472604454,-0.887871214246839,-5.56284938951349,-0.390440147696971,"PDE7B","phosphodiesterase 7B",TRUE
+"239874_at",0.594005743610726,0.0710146209917782,1.89645113311571,-4.32505726575516,1.66757473423128,"PDE8A","phosphodiesterase 8A",TRUE
+"1552931_a_at",0.729273475042162,0.211515170155124,1.28659917551392,-5.16406966653065,0.85094907946389,"PDE8A","phosphodiesterase 8A",TRUE
+"212522_at",0.774230543658252,0.288980754180823,1.08639935400487,-5.38061109605045,0.719507785020507,"PDE8A","phosphodiesterase 8A",TRUE
+"212521_s_at",0.784708646973769,0.308663020095855,1.04196813199944,-5.42427839006436,0.548979066437415,"PDE8A","phosphodiesterase 8A",TRUE
+"1554789_a_at",0.813418501361393,0.363361801357016,0.928089750806733,-5.52863982357485,0.765589189377485,"PDE8B","phosphodiesterase 8B",TRUE
+"235115_at",0.908709061737317,0.620776847964967,0.501773029881232,-5.81779106308078,0.505832724029361,"PDE8B","phosphodiesterase 8B",TRUE
+"213228_at",0.945498722604777,0.754167753677934,0.317058100293922,-5.89083930961749,0.221943790208519,"PDE8B","phosphodiesterase 8B",TRUE
+"237139_at",0.920734496427305,0.662786762074378,0.441981145630522,-5.84498229960889,0.314683290623801,"PDE9A","phosphodiesterase 9A",TRUE
+"205593_s_at",0.978951900396372,0.897735150141265,0.130005486023699,-5.9314547704445,0.165252149278638,"PDE9A","phosphodiesterase 9A",TRUE
+"216867_s_at",0.753438285240305,0.24662615438401,1.19004003956111,-5.27248730790977,0.649848938282524,"PDGFA","platelet derived growth factor subunit A",TRUE
+"205463_s_at",0.841088238127348,0.430848982810792,0.802392271962169,-5.63086899803245,0.413701837450876,"PDGFA","platelet derived growth factor subunit A",TRUE
+"216061_x_at",0.69971536436669,0.171207435871905,1.41418097394432,-5.00989179305298,0.672158526578517,"PDGFB","platelet derived growth factor subunit B",TRUE
+"204200_s_at",0.878218253751206,0.53018461846541,0.637731280325395,-5.74351232601961,0.564531574685529,"PDGFB","platelet derived growth factor subunit B",TRUE
+"216055_at",0.921979068831802,0.667045743498483,0.436013366986149,-5.84751085158602,0.26564489919266,"PDGFB","platelet derived growth factor subunit B",TRUE
+"217112_at",0.942502815705589,0.741957891070802,-0.333412049316738,-5.88568435755082,-0.151093180693108,"PDGFB","platelet derived growth factor subunit B",TRUE
+"222719_s_at",0.896229101808264,0.579417220055309,0.562508242179715,-5.7867332233199,0.811642581453238,"PDGFC","platelet derived growth factor C",TRUE
+"218718_at",0.909052380289506,0.622042645668653,0.49994520305731,-5.81867219810915,0.589943777042864,"PDGFC","platelet derived growth factor C",TRUE
+"219304_s_at",0.957297641945196,0.806808876832824,-0.247488899929694,-5.90989445160631,-0.193334587156156,"PDGFD","platelet derived growth factor D",TRUE
+"222860_s_at",0.975514010346705,0.883341986982259,-0.148435169713865,-5.92895771344563,-0.136873345172953,"PDGFD","platelet derived growth factor D",TRUE
+"1554828_at",0.491581666454407,0.0294742333910067,2.32734588085378,-3.59815604232316,1.54397527662437,"PDGFRA","platelet derived growth factor receptor alpha",TRUE
+"211533_at",0.876705386132589,0.525718569542626,-0.644735238670084,-5.73922247964243,-0.586427387480685,"PDGFRA","platelet derived growth factor receptor alpha",TRUE
+"203131_at",0.904381089098038,0.607172894001843,-0.521528731088749,-5.80806740284358,-0.509823539209873,"PDGFRA","platelet derived growth factor receptor alpha",TRUE
+"215305_at",0.997956098344104,0.990436063364355,-0.0121228942913912,-5.93961189998103,-0.00653203509545675,"PDGFRA","platelet derived growth factor receptor alpha",TRUE
+"202273_at",0.797963285726587,0.332107887104852,0.991581306482069,-5.47180807767769,0.734598988488545,"PDGFRB","platelet derived growth factor receptor beta",TRUE
+"205226_at",0.94333312187812,0.745574203567673,-0.328558873535196,-5.8872409043678,-0.424610125865374,"PDGFRL","platelet derived growth factor receptor like",TRUE
+"200979_at",0.769847953580141,0.278206430895117,-1.11164892625945,-5.35507139821346,-0.404512560404543,"PDHA1","pyruvate dehydrogenase (lipoamide) alpha 1",TRUE
+"200980_s_at",0.899046682581382,0.589079126694621,-0.548135884384895,-5.7943940170814,-0.157463066300348,"PDHA1","pyruvate dehydrogenase (lipoamide) alpha 1",TRUE
+"1555864_s_at",0.936088332012333,0.714286332172923,-0.370829601854173,-5.8729262430298,-0.101360135436019,"PDHA1","pyruvate dehydrogenase (lipoamide) alpha 1",TRUE
+"214518_at",0.697172073261335,0.167491757549267,-1.42710358664764,-4.99360219369629,-0.689815788131069,"PDHA2","pyruvate dehydrogenase (lipoamide) alpha 2",TRUE
+"208911_s_at",0.536186589417525,0.0430648437619525,-2.14615824376079,-3.91527518083191,-0.757705552003811,"PDHB","pyruvate dehydrogenase (lipoamide) beta",TRUE
+"211023_at",0.623503825356688,0.094573471539974,-1.74650860933073,-4.55408244789164,-0.529471653411104,"PDHB","pyruvate dehydrogenase (lipoamide) beta",TRUE
+"203067_at",0.954900985681446,0.794580701022344,-0.263525745360145,-5.90591547363717,-0.0969585107811728,"PDHX","pyruvate dehydrogenase complex component X",TRUE
+"216127_at",0.734577729521114,0.219097447785193,1.26476457681323,-5.18922083478844,0.527608492442146,"PDIA2","protein disulfide isomerase family A member 2",TRUE
+"206889_at",0.774230543658252,0.288090057073752,-1.08846064256079,-5.37854570342247,-0.363512627423536,"PDIA2","protein disulfide isomerase family A member 2",TRUE
+"206691_s_at",0.918373706340477,0.653387772757426,0.455209520762358,-5.8392572261684,0.362249123502384,"PDIA2","protein disulfide isomerase family A member 2",TRUE
+"227033_at",0.768852835478002,0.2739862927495,1.12173241577348,-5.34472660524358,0.510158935853612,"PDIA3","protein disulfide isomerase family A member 3",TRUE
+"229453_at",0.839466826665106,0.425918027786348,0.811131523382391,-5.62421021538395,0.39969281379612,"PDIA3","protein disulfide isomerase family A member 3",TRUE
+"208612_at",0.854246455748088,0.464950253385324,0.743568149935888,-5.6739187538619,0.261162201752901,"PDIA3","protein disulfide isomerase family A member 3",TRUE
+"208658_at",0.972112264314695,0.86601303720431,-0.170694640349275,-5.92550204395513,-0.0734682442212335,"PDIA4","protein disulfide isomerase family A member 4",TRUE
+"211048_s_at",0.980009054680439,0.905948628535854,0.119509608605657,-5.93272937233113,0.0553871598076494,"PDIA4","protein disulfide isomerase family A member 4",TRUE
+"216640_s_at",0.487553723496951,0.0288118167465688,2.33802069047922,-3.57900155394068,0.901082370859312,"PDIA6","protein disulfide isomerase family A member 6",TRUE
+"208638_at",0.522403182336918,0.038202395844572,2.20407486177846,-3.81560060337249,0.707486440380338,"PDIA6","protein disulfide isomerase family A member 6",TRUE
+"207668_x_at",0.527546822913581,0.0402238929142264,2.17922908558352,-3.85856141655652,0.668741483174639,"PDIA6","protein disulfide isomerase family A member 6",TRUE
+"208639_x_at",0.536559328842429,0.0434776516569818,2.14151793734954,-3.92318949478063,0.686190473125322,"PDIA6","protein disulfide isomerase family A member 6",TRUE
+"227255_at",0.760563533925384,0.259697994750913,-1.15674086376952,-5.3081713822889,-0.402204853358199,"PDIK1L","PDLIM1 interacting kinase 1 like",TRUE
+"1554970_at",0.800342373547779,0.336118732180318,0.983211266730516,-5.47949647965455,0.582177546375652,"PDILT","protein disulfide isomerase like, testis expressed",TRUE
+"239798_at",0.805991582894782,0.346343258409262,0.962179926581411,-5.49855278857546,0.462316564038762,"PDK1","pyruvate dehydrogenase kinase 1",TRUE
+"206686_at",0.831875452294783,0.407217629163134,0.844863882268838,-5.59787485770273,0.487619409112342,"PDK1","pyruvate dehydrogenase kinase 1",TRUE
+"226452_at",0.940227139261806,0.732313602335196,0.346395305874016,-5.88140930602291,0.185448541549667,"PDK1","pyruvate dehydrogenase kinase 1",TRUE
+"213724_s_at",0.939166148226364,0.727656211837654,-0.352686801023274,-5.87927961702242,-0.219356508357269,"PDK2","pyruvate dehydrogenase kinase 2",TRUE
+"202590_s_at",0.982884736081404,0.916822040431382,0.105635562648795,-5.93424986670141,0.0694547321862373,"PDK2","pyruvate dehydrogenase kinase 2",TRUE
+"206347_at",0.560295667354693,0.054220178674747,-2.03285846585683,-4.10536356653588,-0.889342371723796,"PDK3","pyruvate dehydrogenase kinase 3",TRUE
+"206348_s_at",0.931370027472813,0.696734622655062,-0.394842228012804,-5.8640341056967,-0.262392908503173,"PDK3","pyruvate dehydrogenase kinase 3",TRUE
+"230085_at",0.955892698633978,0.799718719542043,0.256779048262086,-5.90761966902583,0.160388976381476,"PDK3","pyruvate dehydrogenase kinase 3",TRUE
+"228959_at",0.969577323811311,0.854774630629741,-0.185177268418056,-5.92299557147686,-0.107821529749604,"PDK3","pyruvate dehydrogenase kinase 3",TRUE
+"221957_at",0.971216837324271,0.862982593115075,0.17459608110943,-5.92484684745376,0.0916006441703487,"PDK3","pyruvate dehydrogenase kinase 3",TRUE
+"205960_at",0.791211889207316,0.321595598775843,1.01385603867394,-5.4510592273221,0.92407030460072,"PDK4","pyruvate dehydrogenase kinase 4",TRUE
+"225207_at",0.812302873476553,0.357656029351414,0.939396805497968,-5.51877089096217,1.21851302059533,"PDK4","pyruvate dehydrogenase kinase 4",TRUE
+"1562321_at",0.94632739401154,0.757449333497682,-0.312677923568932,-5.89217641114016,-0.268892448654567,"PDK4","pyruvate dehydrogenase kinase 4",TRUE
+"208690_s_at",0.589867324183875,0.0680595000703275,1.9182266327727,-4.29068820552887,1.60784128166178,"PDLIM1","PDZ and LIM domain 1",TRUE
+"219165_at",0.944323108944215,0.750449731753565,0.322028494035214,-5.88929972748504,0.277809028090195,"PDLIM2","PDZ and LIM domain 2",TRUE
+"232302_at",0.975398143273847,0.882239825501242,0.149848518361258,-5.92875259785747,0.112095098345852,"PDLIM2","PDZ and LIM domain 2",TRUE
+"209621_s_at",0.80877771360499,0.351942192265019,-0.950842124687992,-5.50866960860681,-1.2574427812995,"PDLIM3","PDZ and LIM domain 3",TRUE
+"240289_at",0.947926063538122,0.762931599140813,0.305374175949941,-5.89436498324712,0.150173285767455,"PDLIM3","PDZ and LIM domain 3",TRUE
+"210170_at",0.951006866397403,0.776306339479098,0.287625694061661,-5.89946959392586,0.257458317179506,"PDLIM3","PDZ and LIM domain 3",TRUE
+"218691_s_at",0.255716413540338,0.00368571139133065,3.24574856894182,-1.80406835406609,2.88220438292635,"PDLIM4","PDZ and LIM domain 4",TRUE
+"211564_s_at",0.272829633065398,0.00432953047868573,3.17762458863565,-1.94503518957973,4.99847025343823,"PDLIM4","PDZ and LIM domain 4",TRUE
+"214175_x_at",0.33885751363602,0.00842263120313399,2.89189505992697,-2.52506894420004,3.81668561020334,"PDLIM4","PDZ and LIM domain 4",TRUE
+"214174_s_at",0.709003926008189,0.181585404223003,1.37923789099877,-5.05332684236922,0.965303669342014,"PDLIM4","PDZ and LIM domain 4",TRUE
+"218690_at",0.915580532396172,0.644216765927511,-0.46819700724511,-5.83347546295292,-0.258294441109236,"PDLIM4","PDZ and LIM domain 4",TRUE
+"203242_s_at",0.406049718268978,0.0152579746282326,2.62945726917883,-3.03799509743138,1.41055404597615,"PDLIM5","PDZ and LIM domain 5",TRUE
+"211681_s_at",0.411110107932987,0.0162137313259196,2.60213464726264,-3.09009574136554,1.04276641215356,"PDLIM5","PDZ and LIM domain 5",TRUE
+"212412_at",0.51470556386048,0.0352975139137223,2.24195574550743,-3.749530972736,1.1167107753066,"PDLIM5","PDZ and LIM domain 5",TRUE
+"203243_s_at",0.517859245504688,0.0369297205380672,2.22033671914716,-3.78732116691832,1.16338362450058,"PDLIM5","PDZ and LIM domain 5",TRUE
+"216804_s_at",0.54295328972902,0.0461962720425747,2.11191457130444,-3.97342456593164,1.22163692638938,"PDLIM5","PDZ and LIM domain 5",TRUE
+"216803_at",0.640337040581689,0.111060661541449,1.65971563682873,-4.68027654275059,1.15381116122176,"PDLIM5","PDZ and LIM domain 5",TRUE
+"213684_s_at",0.708894565317004,0.180989769343269,1.3811998510646,-5.05091192226414,0.990409799956665,"PDLIM5","PDZ and LIM domain 5",TRUE
+"221994_at",0.755868740464627,0.250404317937002,1.1802830790563,-5.28303472876158,0.556046976470603,"PDLIM5","PDZ and LIM domain 5",TRUE
+"211680_at",0.812302873476553,0.358342418642709,-0.938030218787258,-5.51996949637027,-0.856038474430845,"PDLIM5","PDZ and LIM domain 5",TRUE
+"241208_at",0.820536502908875,0.380605748989129,0.894620535379013,-5.55720626871131,0.527152730823375,"PDLIM5","PDZ and LIM domain 5",TRUE
+"1569149_at",0.565043084457947,0.0562766973704319,2.01428815892868,-4.13587646696053,1.06267308213161,"PDLIM7","PDZ and LIM domain 7",TRUE
+"1569150_x_at",0.632949074657601,0.103972666598288,1.69558794942857,-4.62870560249802,0.830571465174774,"PDLIM7","PDZ and LIM domain 7",TRUE
+"214121_x_at",0.656693876264681,0.124814713872208,1.59528416934643,-4.77077945814253,0.880606850100046,"PDLIM7","PDZ and LIM domain 7",TRUE
+"203370_s_at",0.657015752622694,0.125695242082308,1.59136525678524,-4.77619456429851,0.708516363295104,"PDLIM7","PDZ and LIM domain 7",TRUE
+"203369_x_at",0.697429077307564,0.167982506064258,1.42538373835716,-4.99577715946339,1.06543994803022,"PDLIM7","PDZ and LIM domain 7",TRUE
+"214266_s_at",0.71105346200454,0.184906412853782,1.36839135963267,-5.06662602564104,0.649459242269702,"PDLIM7","PDZ and LIM domain 7",TRUE
+"214122_at",0.914746370982129,0.640866204672528,0.472962231953723,-5.83131414901203,0.325687187180392,"PDLIM7","PDZ and LIM domain 7",TRUE
+"218273_s_at",0.682744111897512,0.150707580369701,1.48852855238377,-4.91452557396364,1.07159795984729,"PDP1","pyruvate dehyrogenase phosphatase catalytic subunit 1",TRUE
+"222572_at",0.708713388831643,0.180753423370087,1.38197977005996,-5.04995115116621,0.991083120330297,"PDP1","pyruvate dehyrogenase phosphatase catalytic subunit 1",TRUE
+"226855_at",0.68041487556515,0.148113628840667,-1.49851145685775,-4.90141976011454,-0.566945318732728,"PDP2","pyruvate dehyrogenase phosphatase catalytic subunit 2",TRUE
+"232861_at",0.89799228292133,0.586858024186799,-0.551429409584674,-5.79265549449985,-0.253345602201039,"PDP2","pyruvate dehyrogenase phosphatase catalytic subunit 2",TRUE
+"221244_s_at",0.929234395612144,0.688876070875443,0.405669776736976,-5.8598448150561,0.252273831045916,"PDPK1","3-phosphoinositide dependent protein kinase 1",TRUE
+"221898_at",0.712948021516228,0.186945899100106,1.36180647588527,-5.07465724547038,1.91214840210096,"PDPN","podoplanin",TRUE
+"204879_at",0.769258076576208,0.27528980596828,1.11860582061264,-5.34794307189404,1.79104197696669,"PDPN","podoplanin",TRUE
+"208233_at",0.808266620412549,0.351164993020239,0.952408600373587,-5.5072783644704,0.863298261820438,"PDPN","podoplanin",TRUE
+"226658_at",0.812896635201594,0.361883842515721,0.931007112747333,-5.52610402986404,1.23617224414232,"PDPN","podoplanin",TRUE
+"220236_at",0.808233282592165,0.350179297583877,0.954398689912309,-5.50550786904234,0.348502724241236,"PDPR","pyruvate dehydrogenase phosphatase regulatory subunit",TRUE
+"224902_at",0.986889306520757,0.939540357147805,-0.0767130159329691,-5.93681757579174,-0.0311893807510817,"PDPR","pyruvate dehydrogenase phosphatase regulatory subunit",TRUE
+"224904_at",0.996243927234326,0.981247882385422,-0.0237712256142243,-5.93940825916535,-0.00937205095346627,"PDPR","pyruvate dehydrogenase phosphatase regulatory subunit",TRUE
+"225075_at",0.61299046462692,0.0845418153116773,-1.80588279502252,-4.46501985183679,-0.597164811371561,"PDRG1","p53 and DNA damage regulated 1",TRUE
+"213984_at",0.597654932724127,0.0749622407297137,-1.86856814774969,-4.36866446047692,-0.673812391386814,"PDS5A","PDS5 cohesin associated factor A",TRUE
+"213983_s_at",0.604682600348682,0.0787625226683084,-1.84291105427132,-4.40838661423953,-0.610928015132275,"PDS5A","PDS5 cohesin associated factor A",TRUE
+"212138_at",0.884122836669679,0.542875659700354,-0.618000712255738,-5.75535462803743,-0.175646840905307,"PDS5A","PDS5 cohesin associated factor A",TRUE
+"212140_at",0.976371465776674,0.886125050120574,-0.144867699791252,-5.92946682369068,-0.0428426527000774,"PDS5A","PDS5 cohesin associated factor A",TRUE
+"1570119_at",0.398650588126476,0.0139210381356773,2.67050944059504,-2.95922323022593,1.03770919983038,"PDS5B","PDS5 cohesin associated factor B",TRUE
+"242302_at",0.734730148360473,0.219504863413654,1.26360789857109,-5.19054294743078,0.568538714161792,"PDS5B","PDS5 cohesin associated factor B",TRUE
+"204742_s_at",0.76159330462167,0.260717113037253,1.15419752075821,-5.3108603957132,0.565907680096391,"PDS5B","PDS5 cohesin associated factor B",TRUE
+"215888_at",0.839466826665106,0.425785050168931,0.811368072883402,-5.6240290378518,0.305035387236899,"PDS5B","PDS5 cohesin associated factor B",TRUE
+"207956_x_at",0.902770867950228,0.602322953658165,0.52862254759828,-5.80448661078388,0.246210868254327,"PDS5B","PDS5 cohesin associated factor B",TRUE
+"1554634_at",0.930499673921727,0.692509597284846,-0.400657432930384,-5.86179801440649,-0.275569390043453,"PDS5B","PDS5 cohesin associated factor B",TRUE
+"236298_at",0.751464513744428,0.244543157093516,1.19546722302051,-5.26658770006923,0.823826717548303,"PDSS1","prenyl (decaprenyl) diphosphate synthase, subunit 1",TRUE
+"220865_s_at",0.812296665869935,0.356548837388433,-0.941604925577272,-5.51683080904137,-0.289826234966432,"PDSS1","prenyl (decaprenyl) diphosphate synthase, subunit 1",TRUE
+"1555886_at",0.723655063748891,0.200677788323012,1.31888343184524,-5.1262121191762,0.769469426388435,"PDSS2","prenyl (decaprenyl) diphosphate synthase, subunit 2",TRUE
+"217018_at",0.855021564299387,0.467161576411808,-0.739844777873598,-5.67653935159239,-0.533015649380822,"PDSS2","prenyl (decaprenyl) diphosphate synthase, subunit 2",TRUE
+"219307_at",0.95018792835023,0.77369990040735,-0.291076904892626,-5.89850073028419,-0.115385908389779,"PDSS2","prenyl (decaprenyl) diphosphate synthase, subunit 2",TRUE
+"216669_at",0.957571530817866,0.809445926710534,0.24403932125062,-5.9107179011534,0.148965276513998,"PDSS2","prenyl (decaprenyl) diphosphate synthase, subunit 2",TRUE
+"208559_at",0.478045735223536,0.0266236719479774,2.37496342112579,-3.51232913494368,0.888139271551023,"PDX1","pancreatic and duodenal homeobox 1",TRUE
+"210937_s_at",0.710739561811938,0.18396682722931,1.37144432997196,-5.06289153948802,0.660046829868246,"PDX1","pancreatic and duodenal homeobox 1",TRUE
+"210938_at",0.885029460971826,0.545624776135085,0.613759339639926,-5.75785348277334,0.404828067732709,"PDX1","pancreatic and duodenal homeobox 1",TRUE
+"238957_at",0.787661609309111,0.313436737699832,-1.03149661138537,-5.43433125544951,-0.820278863753183,"PDXDC1","pyridoxal dependent decarboxylase domain containing 1",TRUE
+"1560014_s_at",0.939976205834042,0.730440867794383,0.348923385689986,-5.88055809681388,0.185235412256699,"PDXDC1","pyridoxal dependent decarboxylase domain containing 1",TRUE
+"237354_at",0.978255630670068,0.894539147972359,0.134093587188747,-5.93092934776914,0.0532620475929413,"PDXDC1","pyridoxal dependent decarboxylase domain containing 1",TRUE
+"1558430_at",0.983833757326415,0.921033943644308,0.100267194734368,-5.9347879725659,0.0419881582921464,"PDXDC1","pyridoxal dependent decarboxylase domain containing 1",TRUE
+"1560013_at",0.996261754016157,0.981464924442259,-0.0234960378193927,-5.93941459440708,-0.0149886497181946,"PDXDC1","pyridoxal dependent decarboxylase domain containing 1",TRUE
+"1555347_at",0.997466539876354,0.987077155652621,-0.0163808684491459,-5.93955278655574,-0.0104543841561124,"PDXDC1","pyridoxal dependent decarboxylase domain containing 1",TRUE
+"222492_at",0.531571149526209,0.0417591349392864,2.1611047187204,-3.88971015845204,0.815917798695601,"PDXK","pyridoxal (pyridoxine, vitamin B6) kinase",TRUE
+"218019_s_at",0.576578502995171,0.0612802502223126,1.97150796654397,-4.20545465214858,0.826023185071431,"PDXK","pyridoxal (pyridoxine, vitamin B6) kinase",TRUE
+"202671_s_at",0.689985677226298,0.159392883804107,1.45608922006232,-4.95662418774442,0.776095204082656,"PDXK","pyridoxal (pyridoxine, vitamin B6) kinase",TRUE
+"1566671_a_at",0.725276957219979,0.204115868584126,1.30849785119723,-5.13847725335587,1.14193627487214,"PDXK","pyridoxal (pyridoxine, vitamin B6) kinase",TRUE
+"218018_at",0.739367922105944,0.227172568857672,1.2421392941742,-5.21489370494052,0.902577636127617,"PDXK","pyridoxal (pyridoxine, vitamin B6) kinase",TRUE
+"1566670_at",0.823074246722209,0.389590376989265,-0.877576696965793,-5.57138036259229,-0.440571374364764,"PDXK","pyridoxal (pyridoxine, vitamin B6) kinase",TRUE
+"223290_at",0.918041148686074,0.651723072951595,-0.457561015923605,-5.83822220296528,-0.151210152665156,"PDXP///SH3BP1","pyridoxal phosphatase///SH3 domain binding protein 1",TRUE
+"206803_at",0.806216644294069,0.346662942703821,0.961529230056463,-5.49913637766756,0.632888524039296,"PDYN","prodynorphin",TRUE
+"223037_at",0.877857073443889,0.528921354787272,-0.639709146426452,-5.74230546822128,-0.201753321263688,"PDZD11","PDZ domain containing 11",TRUE
+"233025_at",0.429284714913652,0.0188521180442467,2.53388432083984,-3.21905603929381,2.52053266651325,"PDZD2","PDZ domain containing 2",TRUE
+"209493_at",0.497725944448536,0.0307081593673779,2.30803582918408,-3.63267698341378,2.66647238968793,"PDZD2","PDZ domain containing 2",TRUE
+"233026_s_at",0.578925607036084,0.06185360549319,1.96680540504788,-4.21304141628734,1.65241169061209,"PDZD2","PDZ domain containing 2",TRUE
+"1555490_s_at",0.769258076576208,0.276524748398428,-1.11565364502419,-5.35097280790245,-0.913760742077861,"PDZD3","PDZ domain containing 3",TRUE
+"220303_at",0.7717895132349,0.281494270599281,-1.10386990932918,-5.3629953824066,-0.456117166741334,"PDZD3","PDZ domain containing 3",TRUE
+"223543_at",0.834321832770747,0.412499090689691,-0.835239574499041,-5.60549100228129,-0.767488449939377,"PDZD4","PDZ domain containing 4",TRUE
+"220555_s_at",0.592488489935347,0.0694940306934201,1.90755452208623,-4.30756650060613,0.921182709720755,"PDZD7","PDZ domain containing 7",TRUE
+"225829_at",0.758722841981575,0.255974422372055,1.16609684288461,-5.29823486105877,0.490309309958967,"PDZD8","PDZ domain containing 8",TRUE
+"213549_at",0.778295711796067,0.297890294071104,1.06602748861292,-5.40083541170596,0.504364799926186,"PDZD8","PDZ domain containing 8",TRUE
+"225830_at",0.789795896476304,0.318370174863627,1.02079195336323,-5.44451323352315,0.501168833227347,"PDZD8","PDZ domain containing 8",TRUE
+"230416_at",0.852857460895699,0.45899096089357,0.753655055344479,-5.66675673485858,0.358439750215188,"PDZD8","PDZ domain containing 8",TRUE
+"241572_at",0.887865061216281,0.553228841436054,0.602086215204297,-5.76464511334553,0.488387638009083,"PDZD9","PDZ domain containing 9",TRUE
+"205380_at",0.882059205223864,0.539512097688092,-0.62320565250744,-5.7522654149528,-1.18293230944738,"PDZK1","PDZ domain containing 1",TRUE
+"219630_at",0.596382916302699,0.0729512381203923,1.8826075276322,-4.34676450576178,2.20380802774082,"PDZK1IP1","PDZK1 interacting protein 1",TRUE
+"1553589_a_at",0.673068825624289,0.138651562560702,1.53618363095071,-4.851332681239,1.58091955581172,"PDZK1IP1","PDZK1 interacting protein 1",TRUE
+"1555587_at",0.300116716920836,0.00563147374554702,-3.06559839827528,-2.1747553020813,-1.88531480471257,"PDZRN3","PDZ domain containing ring finger 3",TRUE
+"212915_at",0.79016808917264,0.319304504109379,-1.01877774780911,-5.44641836341659,-2.00257602223637,"PDZRN3","PDZ domain containing ring finger 3",TRUE
+"232776_at",0.963120895816356,0.832448368538415,0.214072444206613,-5.91738745021225,0.109702195126008,"PDZRN3","PDZ domain containing ring finger 3",TRUE
+"238165_at",0.748760747870936,0.241917852970097,-1.2023570021093,-5.25906454992155,-0.721267587791139,"PDZRN3-AS1","PDZRN3 antisense RNA 1",TRUE
+"220595_at",0.821745015752602,0.384721320565791,0.886781027094502,-5.56375718383905,0.51767280242241,"PDZRN4","PDZ domain containing ring finger 4",TRUE
+"200788_s_at",0.861113073516266,0.481261666052287,0.716344242000875,-5.69279125127758,0.347801635200838,"PEA15","phosphoprotein enriched in astrocytes 15",TRUE
+"200787_s_at",0.997293485734839,0.986329868705358,-0.0173282183062698,-5.93953723274947,-0.00767601820581199,"PEA15","phosphoprotein enriched in astrocytes 15",TRUE
+"225913_at",0.748924337581408,0.242010039134068,1.20211412179719,-5.25933039690601,0.469280804250159,"PEAK1","pseudopodium enriched atypical kinase 1",TRUE
+"220008_at",0.895213601869362,0.572984774957634,-0.572143321752384,-5.78148984903632,-0.308393318931931,"PEAK1","pseudopodium enriched atypical kinase 1",TRUE
+"228618_at",0.565043084457947,0.0563366196102094,2.01375617521229,-4.13674782859922,2.22486208750644,"PEAR1","platelet endothelial aggregation receptor 1",TRUE
+"205353_s_at",0.70573152022539,0.177864400631894,-1.3915793386709,-5.03808877079683,-0.411522256389565,"PEBP1","phosphatidylethanolamine binding protein 1",TRUE
+"210825_s_at",0.766550448794594,0.267295818128076,-1.13795366781526,-5.32791176811175,-0.337470357054483,"PEBP1","phosphatidylethanolamine binding protein 1",TRUE
+"211941_s_at",0.840041055449124,0.429010897691246,-0.80564264901605,-5.62840031783868,-0.264963752090416,"PEBP1","phosphatidylethanolamine binding protein 1",TRUE
+"227848_at",0.849459315211473,0.45054358814481,-0.768088844805378,-5.6563495295488,-0.469267569397612,"PEBP4","phosphatidylethanolamine binding protein 4",TRUE
+"1559921_at",0.597654932724127,0.073804650596102,1.87660883437758,-4.35613596620851,0.636448838247489,"PECAM1","platelet and endothelial cell adhesion molecule 1",TRUE
+"208981_at",0.763692050369258,0.263726924609455,1.14672877336265,-5.31872684394867,1.024679831205,"PECAM1","platelet and endothelial cell adhesion molecule 1",TRUE
+"208982_at",0.7800665680871,0.301411729627948,1.05809578869178,-5.40861696792245,0.72468990330391,"PECAM1","platelet and endothelial cell adhesion molecule 1",TRUE
+"1558397_at",0.934549881842186,0.709591290256909,0.377230611284712,-5.87060964711235,0.248896906453087,"PECAM1","platelet and endothelial cell adhesion molecule 1",TRUE
+"208983_s_at",0.974435013896831,0.87492715764829,0.159233928329496,-5.9273413194228,0.136339078998871,"PECAM1","platelet and endothelial cell adhesion molecule 1",TRUE
+"223619_x_at",0.924448378036419,0.673786334974875,-0.426600980889172,-5.85143027782737,-0.173877006818806,"PECR","peroxisomal trans-2-enoyl-CoA reductase",TRUE
+"221142_s_at",0.986342822130003,0.935089417838048,0.0823734078933265,-5.93637911346157,0.0597520674266754,"PECR","peroxisomal trans-2-enoyl-CoA reductase",TRUE
+"217923_at",0.648323565874229,0.119483352229828,-1.61951732685741,-4.73706487129757,-0.501728454181963,"PEF1","penta-EF-hand domain containing 1",TRUE
+"212092_at",0.819203514175924,0.376084410321981,-0.903297400841989,-5.54989345071237,-1.05329808388483,"PEG10","paternally expressed 10",TRUE
+"212094_at",0.918041148686074,0.651918368067623,-0.457285013642909,-5.8383439575752,-0.662493703706977,"PEG10","paternally expressed 10",TRUE
+"209243_s_at",0.933548873991014,0.705894422469804,-0.382282060733403,-5.86875386678285,-0.647341042072656,"PEG3","paternally expressed 3",TRUE
+"209242_at",0.947926063538122,0.762854679497456,-0.305476534014967,-5.89433466573426,-0.393407891495853,"PEG3","paternally expressed 3",TRUE
+"230068_s_at",0.987487323337591,0.941056236038077,-0.0747858232549631,-5.93695974304818,-0.0959600387635637,"PEG3-AS1","PEG3 antisense RNA 1",TRUE
+"232304_at",0.92051722798026,0.661662589568179,-0.443559076135814,-5.84430809045701,-0.572139150340017,"PELI1","pellino E3 ubiquitin protein ligase 1",TRUE
+"218319_at",0.936456142259101,0.716423898699561,0.36792057574455,-5.87396612168656,0.391678241455999,"PELI1","pellino E3 ubiquitin protein ligase 1",TRUE
+"232213_at",0.955904644595647,0.800504532958879,-0.255748282883635,-5.90787617019455,-0.131401134977266,"PELI1","pellino E3 ubiquitin protein ligase 1",TRUE
+"230794_at",0.986342822130003,0.934540258928396,0.083071976921897,-5.93632283969106,0.0452892562504426,"PELI2","pellino E3 ubiquitin protein ligase family member 2",TRUE
+"219132_at",0.991254515545788,0.959128260373458,-0.0518304299793376,-5.93837512223764,-0.0625131543243063,"PELI2","pellino E3 ubiquitin protein ligase family member 2",TRUE
+"235431_s_at",0.769847953580141,0.277905879541238,1.11236335647052,-5.35434117916087,0.368217008856696,"PELI3","pellino E3 ubiquitin protein ligase family member 3",TRUE
+"218472_s_at",0.749589620061359,0.242528401991503,1.20074969933828,-5.26082297126714,0.444769818352997,"PELO","pelota homolog (Drosophila)",TRUE
+"1553140_at",0.85334340854827,0.460915825619057,0.75038845935879,-5.66908612709486,0.569171132571888,"PELO","pelota homolog (Drosophila)",TRUE
+"221076_at",0.908466056355731,0.619510448249851,0.503603461274483,-5.81690552752297,0.441148670371066,"PELO","pelota homolog (Drosophila)",TRUE
+"215354_s_at",0.623503825356688,0.0943220917932648,1.74792883048832,-4.55197763410043,0.581174720262888,"PELP1","proline, glutamate and leucine rich protein 1",TRUE
+"207621_s_at",0.393258278493143,0.0134032313160528,2.68741527544837,-2.92661664790851,0.879246075074194,"PEMT","phosphatidylethanolamine N-methyltransferase",TRUE
+"213791_at",0.573647621198441,0.060339231266799,1.97931109866941,-4.1928385824143,1.28825623527175,"PENK","proenkephalin",TRUE
+"237774_at",0.682825347106105,0.150964906089424,-1.48754588012895,-4.9158118428681,-0.646961419908215,"PENK","proenkephalin",TRUE
+"202108_at",0.84772210282622,0.446939907825687,-0.774296100998895,-5.65181656286753,-0.364094889058091,"PEPD","peptidase D",TRUE
+"208518_s_at",0.620912785033482,0.0909969154594933,-1.76702712772313,-4.52355088793539,-1.19696203452995,"PER2","period circadian clock 2",TRUE
+"205251_at",0.623852759019384,0.0955262057340701,-1.74115511220425,-4.56200512297078,-0.98098784279944,"PER2","period circadian clock 2",TRUE
+"1555130_at",0.62110896023334,0.0917606342539793,1.76258833292152,-4.53017806310774,1.23905745091426,"PER3","period circadian clock 3",TRUE
+"1555131_a_at",0.768852835478002,0.272767678586692,1.1246652131261,-5.34170228745807,0.546504841822625,"PER3","period circadian clock 3",TRUE
+"1569701_at",0.870857065562116,0.510704193775947,0.668524599156887,-5.72431610468951,0.681786128329809,"PER3","period circadian clock 3",TRUE
+"221045_s_at",0.914588178928864,0.640402633204311,0.473622404577404,-5.8310130319662,0.253708178753758,"PER3","period circadian clock 3",TRUE
+"1566844_at",0.937504304897146,0.72298426165192,-0.359012575584462,-5.87710014264841,-0.105159280626361,"PER4","period circadian clock 3 pseudogene",TRUE
+"1566843_at",0.985619339356481,0.930583292844266,-0.0881067923460909,-5.93590321091922,-0.0754126858181516,"PER4","period circadian clock 3 pseudogene",TRUE
+"224501_at",0.71454754703986,0.189692669581853,1.35302699331833,-5.08531479250175,0.499641915737075,"PERM1","PPARGC1 and ESRR induced regulator, muscle 1",TRUE
+"217744_s_at",0.325601289240131,0.00746188231216982,2.94446185447426,-2.41987416487635,1.52634239111176,"PERP","PERP, TP53 apoptosis effector",TRUE
+"236009_at",0.40129202983775,0.0143587325820288,2.6566753409856,-2.98583326332987,1.75346762643868,"PERP","PERP, TP53 apoptosis effector",TRUE
+"222392_x_at",0.51531387545335,0.0359774701920469,2.23284113574654,-3.76549028067585,1.15561650280464,"PERP","PERP, TP53 apoptosis effector",TRUE
+"240797_at",0.853297110808539,0.460117154473843,0.751742853616457,-5.66812147830482,0.50108577265533,"PERP","PERP, TP53 apoptosis effector",TRUE
+"1556990_at",0.936992192746977,0.718353025952627,0.365297990190345,-5.87489667859964,0.211334762367694,"PERP","PERP, TP53 apoptosis effector",TRUE
+"202212_at",0.83030603167465,0.402655779954211,-0.853241082916746,-5.59117933778317,-0.277364743422689,"PES1","pescadillo ribosomal biogenesis factor 1",TRUE
+"236434_at",0.986455005400648,0.936835965972306,0.0801519524026503,-5.93655490815931,0.0359921727729282,"PES1","pescadillo ribosomal biogenesis factor 1",TRUE
+"226006_at",0.896115372949367,0.577476664570558,0.565409271534564,-5.78516357776364,0.211034295128311,"PET100","PET100 homolog",TRUE
+"227316_at",0.702809964629668,0.174588692469894,1.40261503700389,-5.0243678498753,0.941084457390785,"PET117","PET117 homolog",TRUE
+"228543_at",0.803487298448767,0.341522616430604,-0.972042050044072,-5.48966361564318,-0.417808265616245,"PET117","PET117 homolog",TRUE
+"225432_s_at",0.81035488031479,0.354111452055105,-0.94648224031396,-5.51253073207111,-0.385030586363831,"PET117///KAT14","PET117 homolog///lysine acetyltransferase 14",TRUE
+"228544_s_at",0.907199422920875,0.616222104369916,-0.508364547261871,-5.81458745142537,-0.226795718733698,"PET117///KAT14","PET117 homolog///lysine acetyltransferase 14",TRUE
+"233396_s_at",0.919372089675945,0.657093113351768,0.449984808546668,-5.84153819799838,0.32139346431586,"PET117///KAT14","PET117 homolog///lysine acetyltransferase 14",TRUE
+"215023_s_at",0.672310118804972,0.138114078727342,-1.53838624348004,-4.84837359389159,-0.523542240936711,"PEX1","peroxisomal biogenesis factor 1",TRUE
+"204873_at",0.717336724649405,0.193047875015845,-1.34243755158031,-5.09809272847952,-0.530803474282257,"PEX1","peroxisomal biogenesis factor 1",TRUE
+"206352_s_at",0.906476756086155,0.613506059041934,0.512306013218407,-5.81265233669738,0.164959462513663,"PEX10","peroxisomal biogenesis factor 10",TRUE
+"206351_s_at",0.96287357728432,0.831245817527344,0.215633892104458,-5.91706137397206,0.0677295106432734,"PEX10","peroxisomal biogenesis factor 10",TRUE
+"205160_at",0.7994347047598,0.334904819774754,-0.985737226126804,-5.47718247653467,-0.655435503211978,"PEX11A","peroxisomal biogenesis factor 11 alpha",TRUE
+"205161_s_at",0.987194724320688,0.940322159083623,0.0757190456268277,-5.93689135150286,0.0878043812903675,"PEX11A","peroxisomal biogenesis factor 11 alpha",TRUE
+"202658_at",0.594972224548427,0.0716523323871968,-1.8918564526941,-4.33227423103894,-0.857972838961523,"PEX11B","peroxisomal biogenesis factor 11 beta",TRUE
+"244126_at",0.967819123289047,0.848565397937455,0.193196151496488,-5.92152030396462,0.0569622903927778,"PEX11G","peroxisomal biogenesis factor 11 gamma",TRUE
+"205094_at",0.951644274920392,0.778076891115981,0.285283325308658,-5.9001206396437,0.0914137738065648,"PEX12","peroxisomal biogenesis factor 12",TRUE
+"1556009_at",0.844169896707408,0.440790240166434,-0.784959506444779,-5.64394907795523,-0.339552502916591,"PEX13","peroxisomal biogenesis factor 13",TRUE
+"205246_at",0.875077279162192,0.521925378573006,-0.650709551410352,-5.73552771290742,-0.233855796329244,"PEX13","peroxisomal biogenesis factor 13",TRUE
+"1558164_s_at",0.895690630367785,0.575539013700864,0.56831085840602,-5.78358580008067,0.444916729316083,"PEX13","peroxisomal biogenesis factor 13",TRUE
+"235093_at",0.934643063207672,0.709986837571179,-0.376690723995321,-5.87080654851705,-0.136280415993312,"PEX13","peroxisomal biogenesis factor 13",TRUE
+"1558163_at",0.959357995170594,0.816239067246308,-0.235166890144659,-5.91278304186633,-0.161285351202659,"PEX13","peroxisomal biogenesis factor 13",TRUE
+"1558915_a_at",0.498703893437511,0.0312987279598077,2.29904452054401,-3.64869400894243,1.57430086121524,"PEX14","peroxisomal biogenesis factor 14",TRUE
+"203503_s_at",0.758268628978425,0.255266435939221,1.16788716131674,-5.29632545675308,0.406459542911183,"PEX14","peroxisomal biogenesis factor 14",TRUE
+"33760_at",0.957073030992577,0.805602428199238,0.249068101346653,-5.90951364609074,0.074255772189316,"PEX14","peroxisomal biogenesis factor 14",TRUE
+"221603_at",0.332429060350567,0.00812438184986098,-2.90757208886868,-2.49377500987641,-1.32905489389051,"PEX16","peroxisomal biogenesis factor 16",TRUE
+"221604_s_at",0.768852835478002,0.273927446225238,-1.12187382047973,-5.34458094818145,-0.384824776421974,"PEX16","peroxisomal biogenesis factor 16",TRUE
+"49878_at",0.769847953580141,0.277544149990152,-1.11322395719075,-5.35346100693772,-0.340042006154412,"PEX16","peroxisomal biogenesis factor 16",TRUE
+"201706_s_at",0.552420073963858,0.0499073017696997,-2.07393805436694,-4.03721241374907,-0.652355481928815,"PEX19","peroxisomal biogenesis factor 19",TRUE
+"201707_at",0.726636642789909,0.206297270201648,-1.30197873864564,-5.1461342601892,-0.515959039004448,"PEX19","peroxisomal biogenesis factor 19",TRUE
+"1561238_at",0.849646596450765,0.451082305531126,0.767163505276736,-5.65702232525816,0.62175119436047,"PEX2","peroxisomal biogenesis factor 2",TRUE
+"228225_at",0.850984014275628,0.454082508634367,-0.762022318319922,-5.6607464205631,-0.249660792801633,"PEX2","peroxisomal biogenesis factor 2",TRUE
+"210296_s_at",0.982909728377256,0.917080265628753,-0.105306346529669,-5.9342836729061,-0.0345108655248225,"PEX2","peroxisomal biogenesis factor 2",TRUE
+"240123_at",0.718706241731185,0.19451690428639,-1.33784657841651,-5.10360634772842,-0.502804501010175,"PEX26","peroxisomal biogenesis factor 26",TRUE
+"219180_s_at",0.84155387670388,0.433359842681257,-0.797966055212844,-5.6342156530682,-0.281316968436466,"PEX26","peroxisomal biogenesis factor 26",TRUE
+"235098_at",0.984441970220849,0.924090935747354,-0.0963727414899201,-5.93516079418245,-0.0443065681191417,"PEX26","peroxisomal biogenesis factor 26",TRUE
+"203972_s_at",0.954054753819891,0.789150341336835,0.270669930746421,-5.90406302159933,0.0920686728492743,"PEX3","peroxisomal biogenesis factor 3",TRUE
+"203970_s_at",0.959862623175279,0.818420114585441,-0.232322375834399,-5.91342902714126,-0.0854666341566581,"PEX3","peroxisomal biogenesis factor 3",TRUE
+"203969_at",0.983204672817844,0.91811556451574,0.103986544010697,-5.93441814107731,0.0366637435876962,"PEX3","peroxisomal biogenesis factor 3",TRUE
+"203244_at",0.831734256479475,0.406519150176516,-0.846142642054201,-5.596856787744,-0.380884235498907,"PEX5","peroxisomal biogenesis factor 5",TRUE
+"215481_s_at",0.944963505981344,0.752307047354714,-0.319544537000276,-5.89007209863693,-0.111310371445046,"PEX5","peroxisomal biogenesis factor 5",TRUE
+"240053_x_at",0.615964925929095,0.087108199493073,-1.79013831893232,-4.48884860700077,-1.47943954273415,"PEX5L","peroxisomal biogenesis factor 5 like",TRUE
+"241833_at",0.879571582519001,0.534096517418784,-0.631622656706244,-5.74721700383483,-0.621135273855614,"PEX5L","peroxisomal biogenesis factor 5 like",TRUE
+"219642_s_at",0.897949253801113,0.586542919721717,-0.551897156109829,-5.79240776928636,-0.392884892511334,"PEX5L","peroxisomal biogenesis factor 5 like",TRUE
+"222910_s_at",0.920491425364243,0.661569442959381,0.443689871479228,-5.84425209915765,0.342725690519561,"PEX5L","peroxisomal biogenesis factor 5 like",TRUE
+"240708_at",0.981836322577249,0.913062999278387,0.110429408145235,-5.93374565921777,0.0882992467817552,"PEX5L-AS2","PEX5L antisense RNA 2",TRUE
+"320_at",0.864726282448413,0.492120974115715,0.698517276239364,-5.70478648716353,0.393759140326933,"PEX6","peroxisomal biogenesis factor 6",TRUE
+"204545_at",0.947326616179611,0.760397527508717,0.308748061145972,-5.89336036607769,0.388201819262877,"PEX6","peroxisomal biogenesis factor 6",TRUE
+"211033_s_at",0.852094603401457,0.457723246491098,-0.755810915336738,-5.66521415660618,-0.296076928780273,"PEX7","peroxisomal biogenesis factor 7",TRUE
+"205420_at",0.982884736081404,0.916837758114087,-0.105615523540577,-5.93425192746946,-0.0429452870596698,"PEX7","peroxisomal biogenesis factor 7",TRUE
+"206390_x_at",0.963379172403332,0.832971233204465,0.213393702515974,-5.91752845575727,0.167701172654692,"PF4","platelet factor 4",TRUE
+"207815_at",0.930083070178974,0.691536112828819,0.401999297081692,-5.86127746300472,0.400593200630082,"PF4V1","platelet factor 4 variant 1",TRUE
+"213302_at",0.97675954390937,0.889078961531552,0.141083331742553,-5.92999337718207,0.0822577857651385,"PFAS","phosphoribosylformylglycinamidine synthase",TRUE
+"201507_at",0.907111393934291,0.615742332850311,-0.509060186459675,-5.8142469773844,-0.257781958107847,"PFDN1","prefoldin subunit 1",TRUE
+"218336_at",0.748632141741128,0.241491957587763,-1.20348000125658,-5.2578347539089,-0.332983254932703,"PFDN2","prefoldin subunit 2",TRUE
+"205362_s_at",0.867099100798202,0.498914217943322,-0.687479963458243,-5.71206861957683,-0.389218282854239,"PFDN4","prefoldin subunit 4",TRUE
+"205360_at",0.89589790053229,0.576684603773817,-0.566594770092136,-5.78451989261287,-0.401343225016034,"PFDN4","prefoldin subunit 4",TRUE
+"205361_s_at",0.925504446660705,0.677130819031166,-0.421945385252077,-5.85333785564444,-0.242217017875843,"PFDN4","prefoldin subunit 4",TRUE
+"207132_x_at",0.697412165374288,0.167807028074025,-1.42599824446544,-4.99500028550559,-0.456344084496273,"PFDN5","prefoldin subunit 5",TRUE
+"210908_s_at",0.728156825353177,0.208337775396198,-1.29592894655738,-5.15321102250551,-0.425011058726529,"PFDN5","prefoldin subunit 5",TRUE
+"207537_at",0.757361197594703,0.253278491182252,1.17293397900919,-5.290929140908,0.745518846073187,"PFKFB1","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1",TRUE
+"237777_at",0.828426831961877,0.398341863964842,-0.861219111513279,-5.5847456416547,-0.498743623217682,"PFKFB1","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1",TRUE
+"240883_at",0.939442751103863,0.728718912063392,-0.351249970022936,-5.87976932616446,-0.164222866347145,"PFKFB1","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1",TRUE
+"226733_at",0.820293495506061,0.379133117563667,0.897439167364757,-5.55483789824535,0.440046806281234,"PFKFB2","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2",TRUE
+"207931_s_at",0.937623890519979,0.723986553039565,0.357654233510531,-5.87757137075022,0.315932566833549,"PFKFB2","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2",TRUE
+"209992_at",0.97928472590149,0.89960806305968,0.127610846172531,-5.93175499875484,0.0949610937378784,"PFKFB2","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2",TRUE
+"238450_at",0.987977863996795,0.942607518247288,0.072813921396533,-5.93710146663766,0.0606945070983498,"PFKFB2","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2",TRUE
+"202464_s_at",0.801587742916188,0.338769764465659,-0.977716613104479,-5.48451139398692,-0.683161684893152,"PFKFB3","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3",TRUE
+"228499_at",0.792243446641505,0.323114530154877,-1.01060656031317,-5.45411213353837,-0.53375519573734,"PFKFB4","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4",TRUE
+"206246_at",0.985425981490741,0.928827522376336,0.090341561867568,-5.93570904906943,0.051569882754305,"PFKFB4","6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4",TRUE
+"201102_s_at",0.966313390701604,0.84287874741515,-0.200551524091803,-5.92011232233891,-0.0737186285751719,"PFKL","phosphofructokinase, liver type",TRUE
+"211065_x_at",0.973804347453872,0.873593246663456,-0.160947485120644,-5.92707442243681,-0.0573651501950057,"PFKL","phosphofructokinase, liver type",TRUE
+"210976_s_at",0.904832003218088,0.610015234384587,-0.517383933433832,-5.81013778867746,-0.25021257787353,"PFKM","phosphofructokinase, muscle",TRUE
+"240202_x_at",0.633098477100746,0.104360946994602,-1.69357003648935,-4.63162871950142,-0.744740947892272,"PFKP","phosphofructokinase, platelet",TRUE
+"201037_at",0.782206338814045,0.304089327424778,1.05210879086697,-5.41445610547437,1.3043509806026,"PFKP","phosphofructokinase, platelet",TRUE
+"200634_at",0.641547541078628,0.111971654427323,1.65524648364591,-4.6866427837864,0.462430445678237,"PFN1","profilin 1",TRUE
+"204992_s_at",0.580630437263151,0.0632141159826172,1.95579908899828,-4.23075000264387,1.20853143200617,"PFN2","profilin 2",TRUE
+"235627_at",0.711977799428804,0.185804033881348,1.3654861794007,-5.07017329399861,0.809014786346619,"PFN4","profilin family member 4",TRUE
+"1557476_at",0.738877082146899,0.225575423048853,1.24656493499086,-5.20990324325379,0.813271903970054,"PFN4","profilin family member 4",TRUE
+"213265_at",0.983051865094694,0.917589949436366,0.104656576092797,-5.93435008652785,0.0588521899741989,"PGA4///PGA3///PGA5","pepsinogen 4, group I (pepsinogen A)///pepsinogen 3, group I (pepsinogen A)///pepsinogen 5, group I (pepsinogen A)",TRUE
+"200886_s_at",0.997608949249317,0.987851622596428,0.015399078195625,-5.93956798334517,0.00426916354532914,"PGAM1","phosphoglycerate mutase 1",TRUE
+"205736_at",0.877546037473893,0.527940731950293,0.641246259562614,-5.74136506923339,0.478391320749677,"PGAM2","phosphoglycerate mutase 2",TRUE
+"1553837_at",0.476975940760709,0.0264460045364528,2.37808460500444,-3.5066692260257,0.703752770498571,"PGAM5","PGAM family member 5, mitochondrial serine/threonine protein phosphatase",TRUE
+"1555943_at",0.789795896476304,0.318561845541691,1.02037841718685,-5.44490465287449,0.35346798029213,"PGAM5","PGAM family member 5, mitochondrial serine/threonine protein phosphatase",TRUE
+"220576_at",0.596382916302699,0.0728859733670092,1.88306879843331,-4.34604301466056,1.09247383565227,"PGAP1","post-GPI attachment to proteins 1",TRUE
+"239725_at",0.646767005028134,0.117914467418755,1.62682064847093,-4.72682700585837,0.740679584180612,"PGAP1","post-GPI attachment to proteins 1",TRUE
+"241801_at",0.675901822624452,0.142391138948559,1.52105021828359,-4.87157247127461,0.840949764003724,"PGAP1","post-GPI attachment to proteins 1",TRUE
+"244321_at",0.816022845943054,0.367019987280944,0.920902755478086,-5.53485556705119,0.380693028242471,"PGAP1","post-GPI attachment to proteins 1",TRUE
+"213469_at",0.858826390511142,0.474840816147192,0.726994990739673,-5.68548743103762,0.386474552097088,"PGAP1","post-GPI attachment to proteins 1",TRUE
+"41858_at",0.756313947022433,0.25127366082514,-1.17805361400317,-5.28543417551768,-0.425953070989953,"PGAP2","post-GPI attachment to proteins 2",TRUE
+"215293_s_at",0.977143718344719,0.891001373170114,-0.138621593591696,-5.93032843360621,-0.0442643574690837,"PGAP2","post-GPI attachment to proteins 2",TRUE
+"221811_at",0.753862100951903,0.247278958551023,-1.18834624769251,-5.27432375293339,-1.44341775231225,"PGAP3","post-GPI attachment to proteins 3",TRUE
+"55616_at",0.827985973549523,0.397440741606057,-0.862892626629938,-5.58338900204764,-0.834983517304375,"PGAP3","post-GPI attachment to proteins 3",TRUE
+"235411_at",0.599670629792675,0.0759856995556223,1.86154888113028,-4.37957035449608,2.26389368532511,"PGBD1","piggyBac transposable element derived 1",TRUE
+"238004_at",0.593339168375633,0.0702360050118866,-1.90211028382836,-4.31615150821054,-0.71682437982289,"PGBD2","piggyBac transposable element derived 2",TRUE
+"241490_s_at",0.708894565317004,0.181391552306529,1.37987585825232,-5.05254189949775,0.413816880553279,"PGBD2","piggyBac transposable element derived 2",TRUE
+"243815_at",0.740476003158683,0.229152705047424,-1.23668519249492,-5.22102287036171,-0.434302298635052,"PGBD4","piggyBac transposable element derived 4",TRUE
+"219225_at",0.762670173856783,0.262112485053642,-1.15072707988746,-5.31452121703336,-1.82456416107956,"PGBD5","piggyBac transposable element derived 5",TRUE
+"1555236_a_at",0.821699646436315,0.384316521060522,0.887549663814342,-5.56311725067614,0.686088583936506,"PGC","progastricsin",TRUE
+"205261_at",0.968457469937034,0.85215337520785,0.188560929442518,-5.92238066494666,0.0651147324000032,"PGC","progastricsin",TRUE
+"1560943_s_at",0.588653540532996,0.0674270579097229,1.92299452297804,-4.28312653978906,0.998871934839362,"PGD","phosphogluconate dehydrogenase",TRUE
+"1560942_at",0.812302873476553,0.360244319575233,0.93425274064823,-5.52327430775205,0.368960387303128,"PGD","phosphogluconate dehydrogenase",TRUE
+"201118_at",0.895758940460776,0.576562389258265,0.56677776485845,-5.78442041626384,0.238651699777954,"PGD","phosphogluconate dehydrogenase",TRUE
+"209652_s_at",0.707898177720919,0.179916837267671,1.38474694322985,-5.04653868064899,1.29497198074232,"PGF","placental growth factor",TRUE
+"215179_x_at",0.994304286761558,0.974000754380311,0.0329610803397517,-5.93915433323434,0.0117375298736349,"PGF","placental growth factor",TRUE
+"219359_at",0.96287357728432,0.831600799272156,0.215172910510354,-5.91715788592487,0.135390964711992,"PGGHG","protein-glucosylgalactosylhydroxylysine glucosidase",TRUE
+"235615_at",0.319095917986488,0.00700851519088757,-2.97156022169506,-2.36535947968692,-1.20269223175836,"PGGT1B","protein geranylgeranyltransferase type I subunit beta",TRUE
+"242844_at",0.73759219552868,0.224387479501259,-1.24987221836992,-5.20616391096505,-0.622055130535898,"PGGT1B","protein geranylgeranyltransferase type I subunit beta",TRUE
+"206288_at",0.757361197594703,0.253287195759247,-1.17291181647972,-5.29095288272462,-0.656473682192119,"PGGT1B","protein geranylgeranyltransferase type I subunit beta",TRUE
+"227068_at",0.854350135157525,0.46523152809983,-0.74309396355329,-5.67425319056739,-0.248717615145665,"PGK1","phosphoglycerate kinase 1",TRUE
+"200738_s_at",0.929614487334131,0.689839097281518,-0.404340285014795,-5.86036521787166,-0.108151523413623,"PGK1","phosphoglycerate kinase 1",TRUE
+"1558365_at",0.932830928398943,0.703722652831772,0.385254316771177,-5.8676505579929,0.385897710275062,"PGK1","phosphoglycerate kinase 1",TRUE
+"200737_at",0.93423034725099,0.708891907042507,-0.378185487475192,-5.8702607147591,-0.131829950904553,"PGK1","phosphoglycerate kinase 1",TRUE
+"217383_at",0.957610494018084,0.809761302420591,-0.243626975266089,-5.91081556341877,-0.0696701200055818,"PGK1","phosphoglycerate kinase 1",TRUE
+"217356_s_at",0.962795886672571,0.830715363280913,-0.216322832535019,-5.91691675286091,-0.0805510967980307,"PGK1","phosphoglycerate kinase 1",TRUE
+"217009_at",0.819479221404744,0.37679946457798,-0.901920589922086,-5.55105817537605,-0.419304751218412,"PGK2","phosphoglycerate kinase 2",TRUE
+"218388_at",0.819479221404744,0.376663598318141,-0.902182062782089,-5.55083710652589,-0.329947072798909,"PGLS","6-phosphogluconolactonase",TRUE
+"218387_s_at",0.857287594027564,0.472343023290003,-0.731161054167288,-5.68260265694703,-0.233236890139176,"PGLS","6-phosphogluconolactonase",TRUE
+"230699_at",0.957017346544368,0.805479479041792,0.249229074018782,-5.9094746942352,0.115665741008018,"PGLS","6-phosphogluconolactonase",TRUE
+"1554316_at",0.972684384655581,0.867917336804887,0.168244406159167,-5.92590598092815,0.0687145646137886,"PGLS","6-phosphogluconolactonase",TRUE
+"207384_at",0.976371465776674,0.887006053469998,0.143738788795824,-5.92962535510964,0.071867549817874,"PGLYRP1","peptidoglycan recognition protein 1",TRUE
+"242817_at",0.929786324276714,0.690169167917089,-0.403884781615495,-5.86054312876662,-0.487447607565013,"PGLYRP2","peptidoglycan recognition protein 2",TRUE
+"1553059_at",0.863003954607479,0.487013018249166,0.706874043128519,-5.69919932729236,0.417775551011854,"PGLYRP3","peptidoglycan recognition protein 3",TRUE
+"220944_at",0.760257770418242,0.258619739771539,1.15943984386792,-5.30531213545013,0.384994803163854,"PGLYRP4","peptidoglycan recognition protein 4",TRUE
+"201968_s_at",0.686108994812404,0.154761185932197,1.47320471623638,-4.93450575592069,1.44968634218144,"PGM1","phosphoglucomutase 1",TRUE
+"225367_at",0.746961829087805,0.238904828628412,1.21033395706403,-5.25030739214222,0.536764109877689,"PGM2","phosphoglucomutase 2",TRUE
+"223738_s_at",0.78157679232668,0.303171335388605,1.05415714737223,-5.41246168398327,0.409932847313323,"PGM2","phosphoglucomutase 2",TRUE
+"225366_at",0.89390639630277,0.569614099457818,0.577214085949695,-5.77869570675003,0.219950597405486,"PGM2","phosphoglucomutase 2",TRUE
+"229256_at",0.709914655587487,0.182825756395933,1.37516861826016,-5.05832650323343,1.06179677525169,"PGM2L1","phosphoglucomutase 2 like 1",TRUE
+"229553_at",0.728262401376535,0.208523157941206,1.29538159435376,-5.15384990970777,0.932999024424419,"PGM2L1","phosphoglucomutase 2 like 1",TRUE
+"238417_at",0.791707425459848,0.322474912390253,1.01197360552977,-5.45282886681678,0.557337294826663,"PGM2L1","phosphoglucomutase 2 like 1",TRUE
+"235149_at",0.854184492233394,0.464381265021827,0.744527899445167,-5.67324123774225,0.535528028297917,"PGM2L1","phosphoglucomutase 2 like 1",TRUE
+"1569448_at",0.89767014756104,0.584795744193298,0.554492957718048,-5.79102928968608,0.169948138652968,"PGM2L1","phosphoglucomutase 2 like 1",TRUE
+"210041_s_at",0.612420348961838,0.0842291355838825,1.80782916922411,-4.46206357849737,1.01057838809081,"PGM3","phosphoglucomutase 3",TRUE
+"221788_at",0.725583196024696,0.204729254047974,1.30665930160463,-5.14063999520215,0.727544420454048,"PGM3","phosphoglucomutase 3",TRUE
+"1554560_at",0.698509433176315,0.16984279952786,1.41890063596324,-5.00395652352075,0.865622037699002,"PGM5","phosphoglucomutase 5",TRUE
+"226303_at",0.734730148360473,0.21939280846405,-1.26392586519286,-5.19017960666391,-1.80444355174302,"PGM5","phosphoglucomutase 5",TRUE
+"208491_s_at",0.789378278298554,0.315942570668363,-1.02604475172668,-5.43952889833009,-0.967470536392077,"PGM5","phosphoglucomutase 5",TRUE
+"231024_at",0.643082025527735,0.113523122606674,1.64770532153274,-4.69735532568236,0.6501200943272,"PGM5-AS1","PGM5 antisense RNA 1",TRUE
+"230595_at",0.969829083058377,0.855540314011017,-0.18418930125415,-5.92317301979848,-0.198643988959095,"PGM5-AS1","PGM5 antisense RNA 1",TRUE
+"1560431_at",0.713330901550199,0.18814973760832,1.35794622132883,-5.07935035830004,1.37415942915824,"PGM5P2","phosphoglucomutase 5 pseudogene 2",TRUE
+"218410_s_at",0.143240208015242,0.000977203430995616,-3.79760115006858,-0.636240950538324,-2.32425015920481,"PGP","phosphoglycolate phosphatase",TRUE
+"222622_at",0.402463840838386,0.0148463176017866,-2.64172447645564,-3.01451755367545,-0.847734316474106,"PGP","phosphoglycolate phosphatase",TRUE
+"237202_at",0.56861088242915,0.0585905057995647,-1.99410269314809,-4.1688313576677,-0.956941299366728,"PGPEP1","pyroglutamyl-peptidase I",TRUE
+"223469_at",0.833105361660875,0.410240398499147,-0.839345907603074,-5.60225144557812,-0.46866396637274,"PGPEP1","pyroglutamyl-peptidase I",TRUE
+"1555165_a_at",0.979329597087865,0.900070575314775,-0.12701961265025,-5.93182826694656,-0.0772894190439306,"PGPEP1","pyroglutamyl-peptidase I",TRUE
+"219891_at",0.993026081687614,0.966781496629752,0.0421184860192727,-5.93881948383153,0.0143844076437567,"PGPEP1","pyroglutamyl-peptidase I",TRUE
+"208305_at",0.708894565317004,0.181353322118575,-1.38000173774603,-5.05238698414914,-2.61434223485807,"PGR","progesterone receptor",TRUE
+"228554_at",0.734577729521114,0.219110305997666,-1.26472804633924,-5.18926260587741,-2.60187407503653,"PGR","progesterone receptor",TRUE
+"201121_s_at",0.8877101263145,0.55282000253247,-0.602711674993898,-5.76428440132748,-0.175796699474381,"PGRMC1","progesterone receptor membrane component 1",TRUE
+"201120_s_at",0.978255630670068,0.894830394773213,-0.133720948909499,-5.93097791369394,-0.0471095101589505,"PGRMC1","progesterone receptor membrane component 1",TRUE
+"213227_at",0.831182446031643,0.405177157490142,-0.84860347229054,-5.59489358413927,-0.421227451082842,"PGRMC2","progesterone receptor membrane component 2",TRUE
+"201701_s_at",0.958792863216689,0.813442681114737,0.238816835036685,-5.91194269102386,0.0884616822668765,"PGRMC2","progesterone receptor membrane component 2",TRUE
+"226266_at",0.872005986651814,0.514657123743584,-0.662224282646585,-5.72831428282305,-0.383204183673982,"PGS1","phosphatidylglycerophosphate synthase 1",TRUE
+"219394_at",0.990810941805126,0.956766608637336,0.0548283492749133,-5.93821940301548,0.018797049049077,"PGS1","phosphatidylglycerophosphate synthase 1",TRUE
+"213638_at",0.942493521265566,0.741531665373221,-0.333984590218034,-5.88549923883187,-0.328502996477165,"PHACTR1","phosphatase and actin regulator 1",TRUE
+"226397_s_at",0.94632739401154,0.757326603399127,-0.312841628008699,-5.89212676982933,-0.247298757130048,"PHACTR1","phosphatase and actin regulator 1",TRUE
+"232045_at",0.949955232645902,0.772873500023551,-0.292171901604364,-5.89819093491684,-0.186271985703979,"PHACTR1","phosphatase and actin regulator 1",TRUE
+"244774_at",0.723649742218726,0.200299833956475,1.32003357627901,-5.12484878980216,0.989491885756821,"PHACTR2","phosphatase and actin regulator 2",TRUE
+"204048_s_at",0.822600785740588,0.387672216516307,0.881193734839969,-5.56839347026995,0.528754411784352,"PHACTR2","phosphatase and actin regulator 2",TRUE
+"204049_s_at",0.840879524142924,0.430496183264187,0.803015476572918,-5.63039639698585,0.449100237868926,"PHACTR2","phosphatase and actin regulator 2",TRUE
+"227947_at",0.917806614232276,0.650946092262937,0.458659447427118,-5.83773693162518,0.316070454289791,"PHACTR2","phosphatase and actin regulator 2",TRUE
+"204047_s_at",0.952293443370532,0.781663991568508,0.280542711828541,-5.90142209720944,0.140549566284097,"PHACTR2","phosphatase and actin regulator 2",TRUE
+"237614_at",0.623503825356688,0.0943836476262044,-1.74758075882508,-4.5524936045851,-0.888798481797819,"PHACTR2-AS1","PHACTR2 antisense RNA 1",TRUE
+"1556859_a_at",0.89390639630277,0.569826529812737,-0.576894060533964,-5.77887275622255,-0.442502899168728,"PHACTR2-AS1","PHACTR2 antisense RNA 1",TRUE
+"227949_at",0.456898036702485,0.0224876564566326,2.45318641415021,-3.36924932202816,1.69686894629679,"PHACTR3","phosphatase and actin regulator 3",TRUE
+"226823_at",0.877074739399942,0.526223132360546,-0.64394232791587,-5.73971038865186,-0.192477835769109,"PHACTR4","phosphatase and actin regulator 4",TRUE
+"219235_s_at",0.972278576610345,0.866551561810638,0.170001620871261,-5.92561688337849,0.0726135866860762,"PHACTR4","phosphatase and actin regulator 4",TRUE
+"234405_s_at",0.467681875277,0.0245837715509117,-2.41201873892587,-3.44486734782949,-0.67763491287174,"PHAX","phosphorylated adaptor for RNA export",TRUE
+"235767_x_at",0.523670563561336,0.0389712755529004,-2.19448725173182,-3.8322139804436,-0.794476223317934,"PHAX","phosphorylated adaptor for RNA export",TRUE
+"231812_x_at",0.726636642789909,0.206191402306021,-1.30229388546787,-5.1457648505094,-0.28043325388996,"PHAX","phosphorylated adaptor for RNA export",TRUE
+"200658_s_at",0.657015752622694,0.125149028063093,-1.59379355425787,-4.77284039462611,-0.708481524464254,"PHB","prohibitin",TRUE
+"200659_s_at",0.752235383514782,0.245518684976516,-1.19292121983084,-5.2693582374808,-0.621425398675461,"PHB","prohibitin",TRUE
+"201600_at",0.995025131654789,0.976664113765648,-0.0295834630546799,-5.93925722120236,-0.00908286115002177,"PHB2","prohibitin 2",TRUE
+"238788_at",0.964181293782946,0.835416637964927,-0.210220626028728,-5.91818173399966,-0.0620670498224793,"PHBP19","prohibitin pseudogene 19",TRUE
+"218338_at",0.647518308302168,0.118401975103202,1.62454257542561,-4.73002424283688,0.752693982313687,"PHC1","polyhomeotic homolog 1",TRUE
+"225958_at",0.8877101263145,0.55279815704833,0.60274510200145,-5.76426511329276,0.190523894758961,"PHC1","polyhomeotic homolog 1",TRUE
+"1557852_at",0.663819586595936,0.131856270415789,1.56456559329142,-4.81294672357252,1.18023116051678,"PHC2","polyhomeotic homolog 2",TRUE
+"238131_at",0.816800680706682,0.36861451481596,0.917785034951292,-5.53753811748231,0.60740323529068,"PHC2","polyhomeotic homolog 2",TRUE
+"200919_at",0.99872918752906,0.99458785610831,-0.00686011514435095,-5.93966055900954,-0.00331021222435268,"PHC2","polyhomeotic homolog 2",TRUE
+"226508_at",0.659870891937597,0.127628256345693,1.58284161134122,-4.78793655494534,0.452947198041141,"PHC3","polyhomeotic homolog 3",TRUE
+"215521_at",0.732074070325545,0.215744010287693,1.27434850298925,-5.17822639231622,0.447177784561386,"PHC3","polyhomeotic homolog 3",TRUE
+"220328_at",0.779582111677482,0.300822954209051,1.05941733532437,-5.40732405459238,0.827998721860844,"PHC3","polyhomeotic homolog 3",TRUE
+"238693_at",0.943464796017993,0.747010187572108,0.326633986379328,-5.88785201282281,0.130815942968587,"PHC3","polyhomeotic homolog 3",TRUE
+"1552644_a_at",0.96351240321323,0.833743504051193,-0.212391388814033,-5.91773586664311,-0.0629552676939111,"PHC3","polyhomeotic homolog 3",TRUE
+"210617_at",0.899046682581382,0.589060907268787,-0.54816287578641,-5.79437981049299,-0.304742626797056,"PHEX","phosphate regulating endopeptidase homolog, X-linked",TRUE
+"239229_at",0.90985106339387,0.62481680817603,-0.495945298215009,-5.82058946825709,-0.355126752055827,"PHEX","phosphate regulating endopeptidase homolog, X-linked",TRUE
+"1558666_at",0.776936981479994,0.295280399468418,1.07194932420152,-5.39499174938961,0.51246773059617,"PHEX-AS1","PHEX antisense RNA 1",TRUE
+"202928_s_at",0.812217582387393,0.356469558426481,0.941763212014011,-5.5166915760353,0.472147145408011,"PHF1","PHD finger protein 1",TRUE
+"40446_at",0.857436624285661,0.472940898649933,0.730162682209196,-5.68329540209899,0.241250349870707,"PHF1","PHD finger protein 1",TRUE
+"225048_at",0.744307803443383,0.235247533753258,-1.22011920915026,-5.23949654875254,-0.649595167479822,"PHF10","PHD finger protein 10",TRUE
+"219126_at",0.831942523499222,0.407889073118988,0.843635934903581,-5.59885112146666,0.305410609613828,"PHF10","PHD finger protein 10",TRUE
+"221816_s_at",0.65284137151906,0.122212436636608,1.60700222328121,-4.75452583167156,0.814207294202783,"PHF11","PHD finger protein 11",TRUE
+"242060_x_at",0.907964244160782,0.617921563904315,0.505902475663646,-5.81578884092963,0.372522144432144,"PHF11","PHD finger protein 11",TRUE
+"231815_at",0.75536453281804,0.249332361869067,-1.18304012077249,-5.28006200379327,-0.367725467160941,"PHF12","PHD finger protein 12",TRUE
+"234939_s_at",0.832605695407954,0.408855688482078,-0.841870431849849,-5.60025243904597,-0.479302646799969,"PHF12","PHD finger protein 12",TRUE
+"225005_at",0.97928472590149,0.899179459686578,-0.128158775256615,-5.93168679373429,-0.0376434982760383,"PHF13","PHD finger protein 13",TRUE
+"228095_at",0.931121627074226,0.69499211782727,-0.397238871899891,-5.86311643677494,-0.15700263834554,"PHF14","PHD finger protein 14",TRUE
+"204525_at",0.994701128358967,0.975565040434306,0.0309772400791337,-5.93921611093862,0.0159882823228763,"PHF14","PHD finger protein 14",TRUE
+"225533_at",0.528412182286162,0.0411117045171592,2.16867321080301,-3.87672251151556,1.03196731468907,"PHF19","PHD finger protein 19",TRUE
+"227212_s_at",0.954337260876625,0.789780570588496,0.269840069331767,-5.9042807264228,0.116131331965608,"PHF19","PHD finger protein 19",TRUE
+"227211_at",0.974884920935236,0.877395747262319,-0.156064033829013,-5.92782753761846,-0.0631226532198674,"PHF19","PHD finger protein 19",TRUE
+"207138_at",0.741877580525799,0.232437706525882,1.22771547630016,-5.23105221629717,0.914791050792265,"PHF2","PHD finger protein 2",TRUE
+"212726_at",0.8920930097751,0.563409657175654,-0.58658814114967,-5.77346748536044,-0.223314741026954,"PHF2","PHD finger protein 2",TRUE
+"235389_at",0.61591966964196,0.0870394209307846,-1.79055501475377,-4.48821990469619,-0.928026306519039,"PHF20","PHD finger protein 20",TRUE
+"209422_at",0.734935310038702,0.220012627583658,-1.26216862764631,-5.19218662499666,-0.648962602257926,"PHF20","PHD finger protein 20",TRUE
+"1569906_s_at",0.837345289209351,0.420203929035425,-0.821338086827018,-5.61634778792635,-0.398678916360794,"PHF20","PHD finger protein 20",TRUE
+"206567_s_at",0.872495559811184,0.515635213294719,-0.660669527886198,-5.72929534789042,-0.292478070952923,"PHF20","PHD finger protein 20",TRUE
+"209423_s_at",0.939290937475152,0.728247389711268,0.351887401801123,-5.87955231672427,0.119801512877051,"PHF20","PHD finger protein 20",TRUE
+"219606_at",0.429170076412192,0.018752924647925,-2.53628370803249,-3.21455175930991,-1.59611098393768,"PHF20L1","PHD finger protein 20-like 1",TRUE
+"230098_at",0.771011793494937,0.27983451714508,-1.1077885826976,-5.35900985493777,-0.510293079248584,"PHF20L1","PHD finger protein 20-like 1",TRUE
+"222133_s_at",0.809930331505913,0.353571400310118,0.947565971321016,-5.51157249632942,0.255294490526337,"PHF20L1","PHD finger protein 20-like 1",TRUE
+"231967_at",0.888964987086071,0.556304289586647,-0.5973889897416,-5.76734251456953,-0.412615520017189,"PHF20L1","PHD finger protein 20-like 1",TRUE
+"226942_at",0.942399211098973,0.741233391387293,0.334385323722767,-5.88536948339036,0.0975505134391241,"PHF20L1","PHD finger protein 20-like 1",TRUE
+"227523_s_at",0.961690794738111,0.826482433711099,0.221824321771351,-5.91574541613767,0.0821119430731088,"PHF20L1","PHD finger protein 20-like 1",TRUE
+"1554472_a_at",0.964720936366595,0.836885487185507,-0.208315758650038,-5.91856923010806,-0.1400300632765,"PHF20L1","PHD finger protein 20-like 1",TRUE
+"203278_s_at",0.497725944448536,0.030515241797456,-2.31100734604115,-3.62737557399175,-0.848888039172945,"PHF21A","PHD finger protein 21A",TRUE
+"1554153_a_at",0.567292616148537,0.0574163543443548,-2.00425558684956,-4.15228343697292,-0.688117480913737,"PHF21A","PHD finger protein 21A",TRUE
+"1558965_at",0.77547560202111,0.292695232335016,-1.07785210701038,-5.3891380837932,-0.940589658294115,"PHF21A","PHD finger protein 21A",TRUE
+"227090_at",0.96635324070119,0.84328276951321,0.200028574701789,-5.9202141569159,0.083045655174204,"PHF21A","PHD finger protein 21A",TRUE
+"1560091_a_at",0.852409445602775,0.458309767874273,-0.754813039748571,-5.66592868293863,-0.600528210827014,"PHF21B","PHD finger protein 21B",TRUE
+"1562309_s_at",0.890341281610277,0.558742700856839,-0.593674347044445,-5.76946120973576,-0.76428389370058,"PHF21B","PHD finger protein 21B",TRUE
+"1555789_s_at",0.946941640414848,0.759011711289245,0.310594694627494,-5.892805876077,0.0828809732486544,"PHF23","PHD finger protein 23",TRUE
+"223081_at",0.947778780715578,0.762286030809489,0.306233346350132,-5.8941101924611,0.0838902022400152,"PHF23","PHD finger protein 23",TRUE
+"37566_at",0.812302873476553,0.357128144578447,-0.940449013767339,-5.51784692903866,-0.637236351524519,"PHF24","PHD finger protein 24",TRUE
+"213636_at",0.972935453987408,0.868781979598962,0.167132231896911,-5.92608740822745,0.0753691551843882,"PHF24","PHD finger protein 24",TRUE
+"1561961_at",0.579036829255831,0.0619863294308986,1.96572232261381,-4.21478703804027,1.91511748647936,"PHF2P1","PHD finger protein 2 pseudogene 1",TRUE
+"217951_s_at",0.519956259865057,0.0375851526738628,2.211899286824,-3.80200968950128,0.709938973238426,"PHF3","PHD finger protein 3",TRUE
+"215718_s_at",0.682504456039784,0.150062265637649,1.4909988974787,-4.91128899746645,0.493077905839748,"PHF3","PHD finger protein 3",TRUE
+"217954_s_at",0.741260241503758,0.231637898574691,1.22989044770136,-5.22862609109159,0.389652420847082,"PHF3","PHD finger protein 3",TRUE
+"217952_x_at",0.7974001826642,0.33057568674195,0.994797193384872,-5.46883833007652,0.357504642775703,"PHF3","PHD finger protein 3",TRUE
+"217953_at",0.993005393257451,0.966606358010306,-0.0423406865754248,-5.93881034396422,-0.03675542112543,"PHF3","PHD finger protein 3",TRUE
+"225309_at",0.993225426079816,0.968470993997523,0.03997510948049,-5.93890517927188,0.0137020491853885,"PHF5A","PHD finger protein 5A",TRUE
+"224442_at",0.856257656023992,0.47004490897407,0.735005545153651,-5.67992666847883,0.458111398392709,"PHF6","PHD finger protein 6",TRUE
+"225501_at",0.873665367559788,0.519239991977778,-0.654953495383603,-5.73288320806772,-0.251178649116886,"PHF6","PHD finger protein 6",TRUE
+"215622_x_at",0.837067957688307,0.419428229311791,0.822730338615421,-5.6152681533144,0.224025041121112,"PHF7","PHD finger protein 7",TRUE
+"221930_at",0.930527241884777,0.692666900080749,0.400440674926308,-5.86188194089817,0.186271060895388,"PHF7","PHD finger protein 7",TRUE
+"221611_s_at",0.976392182310915,0.887527774234243,0.143070350033923,-5.9297186396286,0.098715937876646,"PHF7","PHD finger protein 7",TRUE
+"212916_at",0.694819513561858,0.164355787741761,-1.43819034182378,-4.97953009290112,-0.418527171878385,"PHF8","PHD finger protein 8",TRUE
+"238837_at",0.871165715950006,0.511792114470543,0.666787930813128,-5.72542181450136,0.335505783209949,"PHF8","PHD finger protein 8",TRUE
+"215065_at",0.975398143273847,0.88137332631761,0.150959886526512,-5.92858994568431,0.0961532438764046,"PHF8","PHD finger protein 8",TRUE
+"201397_at",0.891653456393983,0.561466104437569,0.589535486867414,-5.77180681660022,0.469659686299096,"PHGDH","phosphoglycerate dehydrogenase",TRUE
+"230485_at",0.707145212264574,0.178742511815207,1.38864854734657,-5.04171762178853,0.695574787342117,"PHGR1","proline, histidine and glycine rich 1",TRUE
+"213074_at",0.602806347163336,0.0773221133084284,1.852506261952,-4.39357704825537,0.501550410507262,"PHIP","pleckstrin homology domain interacting protein",TRUE
+"212542_s_at",0.704148059811236,0.176093875284225,1.39752384645362,-5.03070896179192,0.422186874174667,"PHIP","pleckstrin homology domain interacting protein",TRUE
+"1557362_at",0.937459167278802,0.722310788110729,0.359925678270246,-5.87678238282657,0.0886900717081356,"PHIP","pleckstrin homology domain interacting protein",TRUE
+"244811_at",0.942502815705589,0.741615507788696,0.333871957301205,-5.88553568107704,0.11007888160113,"PHIP","pleckstrin homology domain interacting protein",TRUE
+"1557363_a_at",0.993213867476782,0.967654618980398,0.0410107769713048,-5.93886433034866,0.0413726532051113,"PHIP","pleckstrin homology domain interacting protein",TRUE
+"229876_at",0.828930228696091,0.399827123752599,0.858466078582084,-5.58697206180236,0.354013052520304,"PHKA1","phosphorylase kinase regulatory subunit alpha 1",TRUE
+"205450_at",0.925504143744672,0.67707801089425,0.422018821445384,-5.8533079256933,0.143319060379792,"PHKA1","phosphorylase kinase regulatory subunit alpha 1",TRUE
+"209438_at",0.666473481658155,0.133239892599175,-1.55869021470925,-4.82093852730406,-0.360544202622646,"PHKA2","phosphorylase kinase regulatory subunit alpha 2",TRUE
+"1559705_s_at",0.858826390511142,0.475071253773221,-0.726611293534438,-5.68575233304298,-0.192913300313673,"PHKA2","phosphorylase kinase regulatory subunit alpha 2",TRUE
+"209439_s_at",0.931370027472813,0.696460367690058,-0.395219282323819,-5.86389009514281,-0.12029283769289,"PHKA2","phosphorylase kinase regulatory subunit alpha 2",TRUE
+"238601_at",0.782471668844017,0.304783999240636,-1.05056165458851,-5.41596019481027,-0.597727335007022,"PHKB","phosphorylase kinase regulatory subunit beta",TRUE
+"202738_s_at",0.841420204214686,0.432180108454297,-0.800043741982293,-5.63264688444064,-0.407612908781765,"PHKB","phosphorylase kinase regulatory subunit beta",TRUE
+"202739_s_at",0.907610731888632,0.61693469339075,-0.507331805735312,-5.81509207947719,-0.24165184233499,"PHKB","phosphorylase kinase regulatory subunit beta",TRUE
+"242248_at",0.957110758335671,0.805776098878664,-0.248840732367566,-5.90956862177385,-0.241934999443668,"PHKB","phosphorylase kinase regulatory subunit beta",TRUE
+"207312_at",0.934200936091995,0.708650416891945,0.378515279977877,-5.87013999932748,0.158206913048978,"PHKG1","phosphorylase kinase catalytic subunit gamma 1",TRUE
+"234729_at",0.990810941805126,0.956409597862636,0.0552815887005767,-5.93819509911323,0.0234382569403504,"PHKG1","phosphorylase kinase catalytic subunit gamma 1",TRUE
+"1556369_a_at",0.280199223932988,0.00460957987234902,-3.15100898113625,-1.99985743340027,-1.99364122546218,"PHKG2","phosphorylase kinase catalytic subunit gamma 2",TRUE
+"203709_at",0.29806620002593,0.00547132447653519,-3.07794213971493,-2.14957937216159,-1.50510444576315,"PHKG2","phosphorylase kinase catalytic subunit gamma 2",TRUE
+"1556368_at",0.669423128374382,0.135543927612163,-1.54901742312776,-4.83404401024267,-1.20448807059365,"PHKG2","phosphorylase kinase catalytic subunit gamma 2",TRUE
+"217999_s_at",0.587626678796111,0.066609228065555,1.92921866187914,-4.27323580620662,1.56048647807635,"PHLDA1","pleckstrin homology like domain family A member 1",TRUE
+"225842_at",0.610273709393098,0.0827427344806773,1.81716810938763,-4.44784703588385,1.68302462399732,"PHLDA1","pleckstrin homology like domain family A member 1",TRUE
+"218000_s_at",0.617775129514679,0.0887794479289425,1.7800991888949,-4.50396319905471,2.97632821192857,"PHLDA1","pleckstrin homology like domain family A member 1",TRUE
+"217996_at",0.624520459874487,0.0961047665937982,1.73792638250051,-4.56677462958217,2.31165856676474,"PHLDA1","pleckstrin homology like domain family A member 1",TRUE
+"217997_at",0.642592458809121,0.113070021598474,1.6498986740258,-4.69424343124757,2.00114157229225,"PHLDA1","pleckstrin homology like domain family A member 1",TRUE
+"217998_at",0.697097569641853,0.166691424334661,1.42991708558731,-4.99003953708762,1.10761047132518,"PHLDA1","pleckstrin homology like domain family A member 1",TRUE
+"209802_at",0.605664606439963,0.0792265800687447,1.83985225254985,-4.41309614101212,0.458806996569927,"PHLDA2","pleckstrin homology like domain family A member 2",TRUE
+"209803_s_at",0.854400503339099,0.465619448401235,-0.742440268315119,-5.67471390064346,-0.50035931057349,"PHLDA2","pleckstrin homology like domain family A member 2",TRUE
+"229494_s_at",0.943988850936011,0.749198777653072,-0.32370267337933,-5.88877581141289,-0.322181450128594,"PHLDA2","pleckstrin homology like domain family A member 2",TRUE
+"235534_at",0.91041966111775,0.627477715407411,0.492116381523899,-5.82241068855735,0.28725300306537,"PHLDA3","pleckstrin homology like domain family A member 3",TRUE
+"218634_at",0.998038817582822,0.991102288077902,-0.0112783735254559,-5.93962152567624,-0.0054138003714197,"PHLDA3","pleckstrin homology like domain family A member 3",TRUE
+"216102_at",0.91653541034501,0.647214761821882,0.463942517040573,-5.83538702078563,0.182050420743205,"PHLDB1","pleckstrin homology like domain family B member 1",TRUE
+"238419_at",0.381135657631489,0.0119921396201483,2.73682498425281,-2.83077679045824,2.61676229333374,"PHLDB2","pleckstrin homology like domain family B member 2",TRUE
+"225688_s_at",0.403035132901446,0.0149392447615586,2.63892757159642,-3.01987501925785,3.04689576089613,"PHLDB2","pleckstrin homology like domain family B member 2",TRUE
+"1554779_s_at",0.517654151778308,0.0367154271105622,2.22312489468012,-3.78245984317544,1.56894910124454,"PHLDB2","pleckstrin homology like domain family B member 2",TRUE
+"1557578_at",0.530125118881302,0.0414791999739225,2.16436405317828,-3.88412055656375,1.95237875272735,"PHLDB2","pleckstrin homology like domain family B member 2",TRUE
+"1554778_at",0.774230543658252,0.288581949554138,1.08732171766472,-5.37968732739152,1.07772890585545,"PHLDB2","pleckstrin homology like domain family B member 2",TRUE
+"236082_at",0.73759219552868,0.224154077160704,-1.25052359082357,-5.20542644309261,-0.604934719848786,"PHLDB3","pleckstrin homology like domain family B member 3",TRUE
+"1557948_at",0.784552021081681,0.307931873149303,-1.04358203390485,-5.42272088231797,-0.536425237828755,"PHLDB3","pleckstrin homology like domain family B member 3",TRUE
+"228874_at",0.95194340202313,0.78036471906719,-0.282259030604862,-5.90095340921653,-0.191124780610607,"PHLDB3","pleckstrin homology like domain family B member 3",TRUE
+"210919_at",0.940227139261806,0.732048499366938,-0.34675303887005,-5.88128922827327,-0.327343658661513,"PHLPP1","PH domain and leucine rich repeat protein phosphatase 1",TRUE
+"212719_at",0.990810941805126,0.954483775801474,0.0577267038054147,-5.93806053538268,0.0284286574596244,"PHLPP1","PH domain and leucine rich repeat protein phosphatase 1",TRUE
+"213407_at",0.592488489935347,0.0695923380405084,-1.90683027038532,-4.30870955680468,-0.80037928642769,"PHLPP2","PH domain and leucine rich repeat protein phosphatase 2",TRUE
+"214944_at",0.933548873991014,0.705887528547186,0.382291490107594,-5.86875037989736,0.184282561434302,"PHLPP2","PH domain and leucine rich repeat protein phosphatase 2",TRUE
+"236218_at",0.9727355927549,0.868016403016347,0.16811696810565,-5.92592683057892,0.133060759874231,"PHOSPHO1","phosphoethanolamine/phosphocholine phosphatase",TRUE
+"230434_at",0.647518308302168,0.118750083340149,-1.62292070695027,-4.73229840238648,-0.705930138290148,"PHOSPHO2","phosphatase, orphan 2",TRUE
+"217505_at",0.55074985379986,0.0489201779607197,2.08378562465199,-4.02074343666715,1.65219203936816,"PHOSPHO2-KLHL23///KLHL23","PHOSPHO2-KLHL23 readthrough///kelch like family member 23",TRUE
+"213610_s_at",0.73936001229895,0.227073810114697,1.24241226236633,-5.21458634103617,0.992925862210901,"PHOSPHO2-KLHL23///KLHL23","PHOSPHO2-KLHL23 readthrough///kelch like family member 23",TRUE
+"237756_at",0.789927874973432,0.318989307462373,-1.01945678001856,-5.44577648305529,-0.71378425021515,"PHOSPHO2-KLHL23///PHOSPHO2///KLHL23","PHOSPHO2-KLHL23 readthrough///phosphatase, orphan 2///kelch like family member 23",TRUE
+"214609_at",0.999503346640971,0.99868286950353,-0.00166950424157716,-5.93968212318521,-0.000915547991695576,"PHOX2A","paired like homeobox 2a",TRUE
+"207009_at",0.98539961718117,0.928438149166864,0.0908372250597598,-5.93566532631443,0.0643117454078528,"PHOX2B","paired like homeobox 2b",TRUE
+"223207_x_at",0.493424420541076,0.0297814465072803,-2.32246979492828,-3.60688876593121,-0.915671576131382,"PHPT1","phosphohistidine phosphatase 1",TRUE
+"225683_x_at",0.643515428391208,0.114100777915104,-1.64491969055974,-4.7013029684133,-0.701312144619182,"PHPT1","phosphohistidine phosphatase 1",TRUE
+"234952_s_at",0.661974206478491,0.129509880535262,-1.574647012735,-4.79917876289858,-0.650199309878383,"PHRF1","PHD and ring finger domains 1",TRUE
+"237379_at",0.82364723261727,0.390725894328196,0.875440928523519,-5.57313869193293,0.539746047139089,"PHRF1","PHD and ring finger domains 1",TRUE
+"215285_s_at",0.689848451630875,0.158663109196481,1.45875899751874,-4.95318782213958,0.943533059556778,"PHTF1","putative homeodomain transcription factor 1",TRUE
+"210191_s_at",0.701265550681908,0.172931731743459,1.40826026348891,-5.01731445236697,0.794984079461157,"PHTF1","putative homeodomain transcription factor 1",TRUE
+"205702_at",0.782015447034031,0.303652271431778,1.05308346490007,-5.41350752982374,0.502533602720841,"PHTF1","putative homeodomain transcription factor 1",TRUE
+"235844_at",0.849646596450765,0.451031239367144,0.767251191475073,-5.6569586032504,0.43196164103396,"PHTF1","putative homeodomain transcription factor 1",TRUE
+"209780_at",0.677013732819214,0.144590568964426,-1.51230124176166,-4.88320072304519,-0.606605316755353,"PHTF2","putative homeodomain transcription factor 2",TRUE
+"217097_s_at",0.756006545489432,0.250882172132789,-1.17905688931938,-5.28435489756278,-0.5004708197625,"PHTF2","putative homeodomain transcription factor 2",TRUE
+"215286_s_at",0.856528422017685,0.470460083065626,0.734310185643724,-5.68041166583388,0.399413591853184,"PHTF2","putative homeodomain transcription factor 2",TRUE
+"1554822_at",0.857598822199292,0.473134172342376,-0.72984009981686,-5.68351904173476,-0.551759547977055,"PHTF2","putative homeodomain transcription factor 2",TRUE
+"1554780_a_at",0.907801535382949,0.617255233276571,-0.506867435752474,-5.81531865814118,-0.226996921568604,"PHTF2","putative homeodomain transcription factor 2",TRUE
+"203335_at",0.931370027472813,0.696339738990391,0.395385144899678,-5.86382670339993,0.324631232825443,"PHYH","phytanoyl-CoA 2-hydroxylase",TRUE
+"226846_at",0.953983577550391,0.788388461034834,-0.271673404529952,-5.90379888491261,-0.213808331966685,"PHYHD1","phytanoyl-CoA dioxygenase domain containing 1",TRUE
+"205325_at",0.125055451060988,0.000741069339620669,3.91109716778563,-0.392270774655529,2.41350648589788,"PHYHIP","phytanoyl-CoA 2-hydroxylase interacting protein",TRUE
+"226623_at",0.991367768700244,0.959843828789819,0.0509221731169511,-5.93842057199022,0.0299922431292368,"PHYHIPL","phytanoyl-CoA 2-hydroxylase interacting protein like",TRUE
+"232488_at",0.6287528932499,0.0998830662349117,-1.71724020817276,-4.597176126505,-1.03403666539935,"PHYKPL","5-phosphohydroxy-L-lysine phospho-lyase",TRUE
+"235669_at",0.863621091805053,0.488961549454615,0.703680264197299,-5.7013420994102,0.395582105373876,"PHYKPL","5-phosphohydroxy-L-lysine phospho-lyase",TRUE
+"226783_at",0.936318756756998,0.715829474224818,-0.368729205628768,-5.87367787490757,-0.158612981403392,"PHYKPL","5-phosphohydroxy-L-lysine phospho-lyase",TRUE
+"226519_s_at",0.94895689004559,0.768772945803419,-0.297610644286948,-5.8966351177347,-0.120947587357232,"PHYKPL","5-phosphohydroxy-L-lysine phospho-lyase",TRUE
+"207938_at",0.838491292648458,0.42350582974889,0.815429693653065,-5.62091043934522,0.297409574172451,"PI15","peptidase inhibitor 15",TRUE
+"229947_at",0.890127364535959,0.558415520870295,0.594172278225469,-5.76917794938654,0.490120181662109,"PI15","peptidase inhibitor 15",TRUE
+"228312_at",0.96287357728432,0.831645666134576,-0.215114649508719,-5.91717006891911,-0.0974027576763712,"PI16","peptidase inhibitor 16",TRUE
+"203691_at",0.364513221153898,0.0106335944788212,2.78989841652831,-2.72696074487181,4.23027307460184,"PI3","peptidase inhibitor 3",TRUE
+"41469_at",0.577967092681182,0.0616075393899575,1.96881885457473,-4.20979457134224,2.13643294700275,"PI3","peptidase inhibitor 3",TRUE
+"215134_at",0.380084968057051,0.0117807903881735,2.74469497688989,-2.81543835014714,0.693180393497544,"PI4K2A","phosphatidylinositol 4-kinase type 2 alpha",TRUE
+"209345_s_at",0.481025719247748,0.0272119350641661,2.36476442883284,-3.53079474576523,0.700589741322696,"PI4K2A","phosphatidylinositol 4-kinase type 2 alpha",TRUE
+"209346_s_at",0.658590024406624,0.126835318730341,1.58632499936407,-4.78314386246272,0.68249465528282,"PI4K2A","phosphatidylinositol 4-kinase type 2 alpha",TRUE
+"207081_s_at",0.401034427893142,0.0143250157782406,-2.65772679640316,-2.98381307403525,-1.33429396317158,"PI4KA","phosphatidylinositol 4-kinase alpha",TRUE
+"213408_s_at",0.587626678796111,0.0664931293462331,-1.93010767976112,-4.27182127408049,-0.8539728426944,"PI4KAP1///PI4KAP2///PI4KA","phosphatidylinositol 4-kinase alpha pseudogene 1///phosphatidylinositol 4-kinase alpha pseudogene 2///phosphatidylinositol 4-kinase alpha",TRUE
+"210417_s_at",0.527826453640453,0.0403769657334661,-2.17739412891533,-3.86172233148139,-0.68521242366886,"PI4KB","phosphatidylinositol 4-kinase beta",TRUE
+"206138_s_at",0.599731655615302,0.0761170688643169,-1.86065387894597,-4.38095883785173,-0.690089216453103,"PI4KB","phosphatidylinositol 4-kinase beta",TRUE
+"206139_at",0.829932700649602,0.401631263401698,-0.855130805891426,-5.58966045529885,-0.238957161324626,"PI4KB","phosphatidylinositol 4-kinase beta",TRUE
+"228165_at",0.660054711393139,0.127848546605058,1.58187706634854,-4.789262188873,1.19987503791582,"PIANP","PILR alpha associated neural protein",TRUE
+"1553566_at",0.823074246722209,0.389630727294515,-0.877500733734173,-5.57144296959172,-0.510433982067235,"PIANP","PILR alpha associated neural protein",TRUE
+"217863_at",0.597654932724127,0.074563320934663,-1.87132675018139,-4.36437045648863,-0.695770736876636,"PIAS1","protein inhibitor of activated STAT 1",TRUE
+"217864_s_at",0.862139171333206,0.485021285249897,-0.710146267363435,-5.69699433660299,-0.258951040102286,"PIAS1","protein inhibitor of activated STAT 1",TRUE
+"217862_at",0.937819354739597,0.724646626057316,-0.356760052846617,-5.87788061164831,-0.138335975355441,"PIAS1","protein inhibitor of activated STAT 1",TRUE
+"1555513_at",0.491581666454407,0.0294645285532019,-2.3275006754835,-3.59787864371881,-1.62738626877708,"PIAS2","protein inhibitor of activated STAT 2",TRUE
+"235107_at",0.708473702007515,0.180560655327383,-1.38261648548763,-5.04916645689059,-0.949398099100448,"PIAS2","protein inhibitor of activated STAT 2",TRUE
+"214442_s_at",0.736223289546449,0.221681167777773,-1.25745696566894,-5.19755621797277,-0.517177277584924,"PIAS2","protein inhibitor of activated STAT 2",TRUE
+"1555514_a_at",0.794560046225353,0.326487840818414,-1.00342783360103,-5.46082511481614,-0.369387819371413,"PIAS2","protein inhibitor of activated STAT 2",TRUE
+"238700_at",0.816966928109267,0.369228616745131,-0.916586697516311,-5.53856696102625,-0.407932192319544,"PIAS2","protein inhibitor of activated STAT 2",TRUE
+"37433_at",0.827825169467994,0.396945392880099,-0.863813602775514,-5.58264136490286,-0.395792302551662,"PIAS2","protein inhibitor of activated STAT 2",TRUE
+"1556492_a_at",0.849303815076661,0.450171869031373,-0.768727726707634,-5.65588456438403,-0.767480535823863,"PIAS2","protein inhibitor of activated STAT 2",TRUE
+"243624_at",0.869469607613312,0.506685699822137,-0.67495740343666,-5.72019644858497,-0.335494793752662,"PIAS2","protein inhibitor of activated STAT 2",TRUE
+"214593_at",0.993892931327222,0.971428254213691,0.0362238445524426,-5.93904439283353,0.0316940885139037,"PIAS2","protein inhibitor of activated STAT 2",TRUE
+"203035_s_at",0.748184017928985,0.240436431335087,-1.20626964570656,-5.25477550158109,-0.541705712351446,"PIAS3","protein inhibitor of activated STAT 3",TRUE
+"212881_at",0.462909149139635,0.0234755969653698,-2.43335903532508,-3.40575554368541,-0.791609157553635,"PIAS4","protein inhibitor of activated STAT 4",TRUE
+"212879_x_at",0.767727587789514,0.270056860920132,-1.13122378543356,-5.33491379456171,-0.479798776656199,"PIAS4","protein inhibitor of activated STAT 4",TRUE
+"213239_at",0.552420073963858,0.0496099608799499,2.07688582708085,-4.03228788715496,0.741653731721467,"PIBF1","progesterone immunomodulatory binding factor 1",TRUE
+"215832_x_at",0.540483367247649,0.0449886028373156,2.12486579695385,-3.95150167793535,0.541894651694198,"PICALM","phosphatidylinositol binding clathrin assembly protein",TRUE
+"215236_s_at",0.634684756518518,0.105624080467526,1.68704923825472,-4.64105670146077,0.698604785774387,"PICALM","phosphatidylinositol binding clathrin assembly protein",TRUE
+"212506_at",0.728385463227073,0.209345543729951,1.2929579891221,-5.15667606593748,0.482576663303824,"PICALM","phosphatidylinositol binding clathrin assembly protein",TRUE
+"212511_at",0.838991915745708,0.424475434354966,0.813700172214225,-5.62224018811913,0.388948305111972,"PICALM","phosphatidylinositol binding clathrin assembly protein",TRUE
+"203134_at",0.969642324744141,0.855106027132826,0.184749641865485,-5.92307249341669,0.067837745119153,"PICALM","phosphatidylinositol binding clathrin assembly protein",TRUE
+"204746_s_at",0.713673813939397,0.188879121369003,1.35561682945914,-5.08217693913578,0.574623493746065,"PICK1","protein interacting with PRKCA 1",TRUE
+"1559254_at",0.675118548055585,0.141251405659943,1.52562757345114,-4.86546741767601,1.29940950369464,"PICSAR","P38 inhibited cutaneous squamous cell carcinoma associated lincRNA",TRUE
+"237866_at",0.94740898733987,0.760641900874093,0.308422541544797,-5.89345777042561,0.245783770056494,"PID1","phosphotyrosine interaction domain containing 1",TRUE
+"219093_at",0.966627009027918,0.844868248878393,0.197976946012679,-5.92061111514919,0.209523778090829,"PID1","phosphotyrosine interaction domain containing 1",TRUE
+"237867_s_at",0.998011235061589,0.990552909580559,-0.0119747768807641,-5.93961363843582,-0.00858270457010679,"PID1","phosphotyrosine interaction domain containing 1",TRUE
+"219019_at",0.778955753047799,0.299934056867878,-1.06141602023248,-5.40536592524204,-0.793597224688574,"PIDD1","p53-induced death domain protein 1",TRUE
+"221640_s_at",0.90415231543826,0.606423602013604,0.522622913726913,-5.80751815807295,0.283545367184595,"PIDD1","p53-induced death domain protein 1",TRUE
+"1566111_at",0.821187434813103,0.382328271525677,0.891332679378266,-5.55996019447578,0.576324279295306,"PIEZO1","piezo type mechanosensitive ion channel component 1",TRUE
+"202771_at",0.910165867297668,0.626566727814301,0.493426406208917,-5.82178912822809,0.180803801228361,"PIEZO1","piezo type mechanosensitive ion channel component 1",TRUE
+"1566110_at",0.925821452712582,0.678933108066333,0.419440491779537,-5.85435569406446,0.130643833485414,"PIEZO1","piezo type mechanosensitive ion channel component 1",TRUE
+"1563584_at",0.756601922352523,0.252005733344504,-1.17618064129615,-5.28744688610305,-0.780378467721226,"PIEZO2","piezo type mechanosensitive ion channel component 2",TRUE
+"222908_at",0.795924451457704,0.328153978541964,-0.999901136295765,-5.46410710757989,-0.956107104284784,"PIEZO2","piezo type mechanosensitive ion channel component 2",TRUE
+"1564015_at",0.853297110808539,0.460113059502615,0.751749801528825,-5.66811652550289,0.727308688301968,"PIEZO2","piezo type mechanosensitive ion channel component 2",TRUE
+"1562488_at",0.866077812635028,0.496785567929701,0.690929211557301,-5.70980479074475,0.344759509187235,"PIEZO2","piezo type mechanosensitive ion channel component 2",TRUE
+"219602_s_at",0.964263441785771,0.835681902489855,-0.209876560822781,-5.91825198509385,-0.0950141121606869,"PIEZO2","piezo type mechanosensitive ion channel component 2",TRUE
+"1565774_at",0.968039462275721,0.84939597920833,0.192122761888618,-5.92172139217298,0.11983655127026,"PIEZO2","piezo type mechanosensitive ion channel component 2",TRUE
+"228252_at",0.689848451630875,0.158777015133704,1.45834163555229,-4.95372536065623,0.472495400804611,"PIF1","PIF1 5'-to-3' DNA helicase",TRUE
+"1555591_at",0.955892698633978,0.799751278431984,0.256736334551258,-5.90763031849527,0.159135374834896,"PIF1","PIF1 5'-to-3' DNA helicase",TRUE
+"228100_at",0.846898808963473,0.44556093717118,-0.776679387807634,-5.65006697459585,-0.719106103364378,"PIFO","primary cilia formation",TRUE
+"205281_s_at",0.955816406528307,0.798652228923964,0.258178438006331,-5.90726979675522,0.0810570267827462,"PIGA","phosphatidylinositol glycan anchor biosynthesis class A",TRUE
+"242760_x_at",0.859276375962637,0.476249055332049,-0.724651861536124,-5.68710303959221,-0.301970356364995,"PIGB","phosphatidylinositol glycan anchor biosynthesis class B",TRUE
+"205452_at",0.92777930247318,0.683324092021811,-0.413349093431005,-5.85680600527648,-0.136867639398298,"PIGB","phosphatidylinositol glycan anchor biosynthesis class B",TRUE
+"216593_s_at",0.398650588126476,0.0139955487044284,-2.66812571033206,-2.96381300900917,-0.825967879834385,"PIGC","phosphatidylinositol glycan anchor biosynthesis class C",TRUE
+"202846_s_at",0.467684979746874,0.024592488646955,-2.41185443131057,-3.4451677541021,-0.714733925149808,"PIGC","phosphatidylinositol glycan anchor biosynthesis class C",TRUE
+"215242_at",0.888610474399596,0.554839923097487,0.599623864147787,-5.76606167331074,0.314759807211005,"PIGC","phosphatidylinositol glycan anchor biosynthesis class C",TRUE
+"205077_s_at",0.675352428480841,0.141581339037045,1.52429939835658,-4.86724037707373,0.464032166788622,"PIGF","phosphatidylinositol glycan anchor biosynthesis class F",TRUE
+"205078_at",0.835838027302116,0.415439133107031,0.829915815294421,-5.60966889502777,0.321712836532518,"PIGF","phosphatidylinositol glycan anchor biosynthesis class F",TRUE
+"231692_at",0.18706932688577,0.00184417681191458,3.53541195639267,-1.19584640074665,1.67679185242429,"PIGG","phosphatidylinositol glycan anchor biosynthesis class G",TRUE
+"218652_s_at",0.255716413540338,0.0036747089524137,-3.24701045388612,-1.80144874075842,-1.01200044681922,"PIGG","phosphatidylinositol glycan anchor biosynthesis class G",TRUE
+"233654_at",0.711902920992134,0.185529841282281,-1.36637243397737,-5.06909182973133,-0.978577893546853,"PIGG","phosphatidylinositol glycan anchor biosynthesis class G",TRUE
+"1563842_at",0.917887697142565,0.6513261081452,-0.45812214067472,-5.83797444853057,-0.217441311834021,"PIGG","phosphatidylinositol glycan anchor biosynthesis class G",TRUE
+"209625_at",0.557589172116298,0.0524400996951057,-2.04944658299257,-4.07795137222186,-0.789028233635134,"PIGH","phosphatidylinositol glycan anchor biosynthesis class H",TRUE
+"209707_at",0.661974206478491,0.129508591412361,-1.57465259301809,-4.79917112283044,-0.481377449489138,"PIGK","phosphatidylinositol glycan anchor biosynthesis class K",TRUE
+"227639_at",0.863230457544525,0.487281646778035,-0.706433304700544,-5.69949557777522,-0.244687589998037,"PIGK","phosphatidylinositol glycan anchor biosynthesis class K",TRUE
+"1555394_at",0.940044918888428,0.730878443898376,-0.348332477126891,-5.88075760470247,-0.24079622981379,"PIGK","phosphatidylinositol glycan anchor biosynthesis class K",TRUE
+"1560391_at",0.358427723880268,0.00990239380227772,2.82119328295838,-2.66533980825008,1.94237564835704,"PIGL","phosphatidylinositol glycan anchor biosynthesis class L",TRUE
+"239943_x_at",0.518874125067442,0.0372746744485433,2.21587927957092,-3.79508524903946,1.20931483490666,"PIGL","phosphatidylinositol glycan anchor biosynthesis class L",TRUE
+"205873_at",0.64513208805899,0.116033004295421,1.63568727324486,-4.71435002177513,0.462884090301559,"PIGL","phosphatidylinositol glycan anchor biosynthesis class L",TRUE
+"213889_at",0.672329541745581,0.138177711953371,1.53812510613847,-4.84872459299644,0.647503474275128,"PIGL","phosphatidylinositol glycan anchor biosynthesis class L",TRUE
+"232262_at",0.820611742812032,0.380978685043245,0.893907868924592,-5.55780399860569,0.561846466909269,"PIGL","phosphatidylinositol glycan anchor biosynthesis class L",TRUE
+"236622_at",0.501717436797406,0.032306093186903,-2.28406026769796,-3.6753056561439,-1.0567363196252,"PIGM","phosphatidylinositol glycan anchor biosynthesis class M",TRUE
+"235168_at",0.534256384815859,0.0423708655810873,-2.15405042760748,-3.9017899210909,-1.04726763490897,"PIGM","phosphatidylinositol glycan anchor biosynthesis class M",TRUE
+"223470_at",0.567292616148537,0.0573904377238529,-2.0044817604044,-4.15191416233908,-0.828294571978253,"PIGM","phosphatidylinositol glycan anchor biosynthesis class M",TRUE
+"232101_s_at",0.682539393883246,0.150356568128787,-1.48987119954673,-4.9127670110457,-0.861152209676959,"PIGN","phosphatidylinositol glycan anchor biosynthesis class N",TRUE
+"219048_at",0.696440263939453,0.166423555427009,-1.43086117783968,-4.98884277179546,-1.10827692214837,"PIGN","phosphatidylinositol glycan anchor biosynthesis class N",TRUE
+"214991_s_at",0.346875625018457,0.00892645641336935,-2.86657832385534,-2.57546105167532,-1.44799371221175,"PIGO","phosphatidylinositol glycan anchor biosynthesis class O",TRUE
+"209998_at",0.643688366500038,0.114370365177786,-1.64362371671394,-4.70313780754216,-0.625317294377195,"PIGO","phosphatidylinositol glycan anchor biosynthesis class O",TRUE
+"214990_at",0.974536463688956,0.87568957411539,0.158254739219859,-5.92749255460667,0.103965600158258,"PIGO","phosphatidylinositol glycan anchor biosynthesis class O",TRUE
+"221689_s_at",0.955892698633978,0.799629986753945,0.256895458476101,-5.90759063645743,0.0825252313295319,"PIGP","phosphatidylinositol glycan anchor biosynthesis class P",TRUE
+"204144_s_at",0.593339168375633,0.070220204525555,-1.90222569329711,-4.31596969666986,-0.541152988953576,"PIGQ","phosphatidylinositol glycan anchor biosynthesis class Q",TRUE
+"1555359_at",0.684874883853079,0.153385896704555,1.47836675631061,-4.9277937947088,0.613927659491215,"PIGQ","phosphatidylinositol glycan anchor biosynthesis class Q",TRUE
+"226147_s_at",0.842224301155785,0.435783546107634,0.793708493751634,-5.63741836211886,0.847685567389478,"PIGR","polymeric immunoglobulin receptor",TRUE
+"204213_at",0.869574215769297,0.506975554757084,-0.674492448482946,-5.72049547812439,-0.217836387061036,"PIGR","polymeric immunoglobulin receptor",TRUE
+"223148_at",0.961146128665821,0.822663428818274,0.226793848083289,-5.91466217563836,0.0789169390122222,"PIGS","phosphatidylinositol glycan anchor biosynthesis class S",TRUE
+"217770_at",0.832605695407954,0.409084912567112,-0.841452148515512,-5.60058403788417,-0.343031807911814,"PIGT","phosphatidylinositol glycan anchor biosynthesis class T",TRUE
+"1568986_x_at",0.99831424973582,0.991850541561948,-0.0103298813193755,-5.9396315081061,-0.00410854577580011,"PIGT","phosphatidylinositol glycan anchor biosynthesis class T",TRUE
+"225903_at",0.863569008901048,0.488850213823832,-0.703862553262902,-5.70122004679077,-0.306726444409472,"PIGU","phosphatidylinositol glycan anchor biosynthesis class U",TRUE
+"219238_at",0.838991915745708,0.424424698196281,0.813790611014163,-5.62217071953345,0.318621859706479,"PIGV","phosphatidylinositol glycan anchor biosynthesis class V",TRUE
+"51146_at",0.851319596585235,0.454928884600804,0.760575665130906,-5.66179005788664,0.302762673225368,"PIGV","phosphatidylinositol glycan anchor biosynthesis class V",TRUE
+"240375_at",0.952339611416198,0.781891289759127,0.280242543032196,-5.90150377507918,0.204878034585306,"PIGV","phosphatidylinositol glycan anchor biosynthesis class V",TRUE
+"1558292_s_at",0.708309103286544,0.180189690308414,-1.38384330768136,-5.04765366401551,-0.60246923383875,"PIGW","phosphatidylinositol glycan anchor biosynthesis class W",TRUE
+"1552291_at",0.835973067952943,0.41721765243264,-0.826706859581435,-5.61217509455116,-0.336064300392307,"PIGX","phosphatidylinositol glycan anchor biosynthesis class X",TRUE
+"227403_at",0.897699110987203,0.584965442525607,0.554240666019147,-5.79116354267272,0.257160566649446,"PIGX","phosphatidylinositol glycan anchor biosynthesis class X",TRUE
+"1563111_a_at",0.953983577550391,0.788004524383691,-0.272179196055499,-5.90366538142929,-0.114370557659846,"PIGX","phosphatidylinositol glycan anchor biosynthesis class X",TRUE
+"220041_at",0.995810723090838,0.979873310775931,0.0255140906286873,-5.93936642281143,0.0128300602977545,"PIGZ","phosphatidylinositol glycan anchor biosynthesis class Z",TRUE
+"217872_at",0.998521211988017,0.993772871519487,0.00789316260953184,-5.93965313577972,0.00311214191773246,"PIH1D1","PIH1 domain containing 1",TRUE
+"235062_at",0.888964987086071,0.55629185308197,0.597407957049319,-5.76733166355079,0.244821580161992,"PIH1D2","PIH1 domain containing 2",TRUE
+"231389_at",0.784789297644843,0.30903025415391,1.04115853478389,-5.42505888066727,0.394213961916209,"PIH1D3","PIH1 domain containing 3",TRUE
+"234426_x_at",0.81836001261482,0.371603548846605,0.911964756321866,-5.54252356064822,1.0950313144389,"PIH2","pregnancy-induced hypertension syndrome-related protein",TRUE
+"234420_at",0.820611742812032,0.381173949176159,-0.893534909292246,-5.55811663277768,-0.844754776157355,"PIH2","pregnancy-induced hypertension syndrome-related protein",TRUE
+"226459_at",0.177045583630671,0.00158718590931058,3.59761119072489,-1.06371968406246,2.90485071616483,"PIK3AP1","phosphoinositide-3-kinase adaptor protein 1",TRUE
+"1554508_at",0.402463840838386,0.0147901648279026,2.64342254760522,-3.01126357544958,2.32989929499836,"PIK3AP1","phosphoinositide-3-kinase adaptor protein 1",TRUE
+"1553694_a_at",0.622917527985155,0.0934430115109277,1.75292100529743,-4.54456904225714,0.601923582134697,"PIK3C2A","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",TRUE
+"235792_x_at",0.623503825356688,0.0944301085848651,1.74731817088971,-4.55288280641553,0.689103064816551,"PIK3C2A","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",TRUE
+"226094_at",0.685360765794715,0.153990442395068,1.47609303061679,-4.93075255145676,0.516064232451908,"PIK3C2A","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",TRUE
+"241905_at",0.724970327905974,0.202569027718232,1.31315347896119,-5.13298919532382,1.04400738494225,"PIK3C2A","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",TRUE
+"1569022_a_at",0.757361197594703,0.253306265775203,1.1728632647185,-5.29100489288074,0.48137888271099,"PIK3C2A","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",TRUE
+"1569588_x_at",0.812302873476553,0.360366371350426,-0.934010784025649,-5.52348557142164,-0.362414960501087,"PIK3C2A","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",TRUE
+"1569021_at",0.828912793879547,0.399761165612852,-0.858588196922703,-5.58687344348191,-0.845783128465257,"PIK3C2A","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",TRUE
+"213070_at",0.831875452294783,0.407743073772754,0.843902831193486,-5.59863904172588,0.31430908381987,"PIK3C2A","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",TRUE
+"1569587_at",0.998047179825832,0.991277860932155,0.0110558150272547,-5.9396239466886,0.00908336705036028,"PIK3C2A","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha",TRUE
+"204484_at",0.717383438122835,0.193165189999673,-1.34206991637453,-5.0985348307995,-0.655917943953074,"PIK3C2B","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta",TRUE
+"215129_at",0.729273475042162,0.211620278832674,1.28629240231224,-5.16442557781912,0.696261949813948,"PIK3C2G","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma",TRUE
+"229705_at",0.778580821633075,0.298656624297202,-1.06429573305281,-5.4025388292284,-0.484102371710597,"PIK3C3","phosphatidylinositol 3-kinase catalytic subunit type 3",TRUE
+"241304_at",0.890444623541856,0.559093138977282,0.593141187496665,-5.76976425613806,0.530973487554196,"PIK3C3","phosphatidylinositol 3-kinase catalytic subunit type 3",TRUE
+"215394_at",0.952293443370532,0.781654024242141,0.280555875229683,-5.90141851337671,0.107527932983138,"PIK3C3","phosphatidylinositol 3-kinase catalytic subunit type 3",TRUE
+"232086_at",0.957174671135192,0.806033482334601,-0.248503791599881,-5.90964999910149,-0.208605813735261,"PIK3C3","phosphatidylinositol 3-kinase catalytic subunit type 3",TRUE
+"1569272_at",0.957430653957785,0.807558762684868,-0.246507648461726,-5.91012985573497,-0.145748548934828,"PIK3C3","phosphatidylinositol 3-kinase catalytic subunit type 3",TRUE
+"239300_at",0.990810941805126,0.95670762270411,-0.0549032334568134,-5.93821540132052,-0.0319199207439924,"PIK3C3","phosphatidylinositol 3-kinase catalytic subunit type 3",TRUE
+"204297_at",0.998402960775648,0.99350909715447,-0.0082275160861929,-5.93965051051525,-0.00391828082226908,"PIK3C3","phosphatidylinositol 3-kinase catalytic subunit type 3",TRUE
+"204369_at",0.661974206478491,0.129558047306664,1.57443854413464,-4.79946416588908,0.578252216337054,"PIK3CA","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",TRUE
+"231854_at",0.905462783815257,0.611724223092649,0.514896243704772,-5.81137269453392,0.159991541504241,"PIK3CA","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",TRUE
+"235980_at",0.971242929121865,0.863451688929603,0.17399197995812,-5.92494926442685,0.0617028076409634,"PIK3CA","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",TRUE
+"217620_s_at",0.962435044681084,0.828812839954275,0.218794664808015,-5.91639409078916,0.0854312228402208,"PIK3CB","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta",TRUE
+"212688_at",0.98539961718117,0.928398194181316,0.0908880881596208,-5.93566082612581,0.0296982267434451,"PIK3CB","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta",TRUE
+"203879_at",0.134242602708516,0.000840003017383041,3.85971977610014,-0.502808759637127,2.72487416397683,"PIK3CD","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",TRUE
+"211230_s_at",0.468735421183467,0.0249657602548751,2.40486874327885,-3.45792938884915,0.71059814823721,"PIK3CD","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",TRUE
+"1559638_at",0.987742637880475,0.941751447497231,-0.0739020728296278,-5.93702372755435,-0.0364397952581541,"PIK3CD-AS1","PIK3CD antisense RNA 1",TRUE
+"1557341_x_at",0.597654932724127,0.074681115060415,1.87051084510055,-4.36564094935323,1.23277489044561,"PIK3CD-AS2","PIK3CD antisense RNA 2",TRUE
+"1557339_at",0.8920930097751,0.563832578686973,-0.585947487010768,-5.7738273938992,-0.40943971323314,"PIK3CD-AS2","PIK3CD antisense RNA 2",TRUE
+"206369_s_at",0.514490373584066,0.0346667394226756,2.25055533945853,-3.73443770685318,0.840805071852438,"PIK3CG","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma",TRUE
+"239294_at",0.574207162627168,0.0604505976786827,1.97838202672391,-4.19434246984514,1.33414067204539,"PIK3CG","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma",TRUE
+"206370_at",0.843480691578142,0.438795085698347,0.788438600118331,-5.64136025735757,0.758116405880798,"PIK3CG","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma",TRUE
+"221756_at",0.800342373547779,0.336083287853015,-0.983284931718063,-5.47942907249975,-0.744196054512638,"PIK3IP1","phosphoinositide-3-kinase interacting protein 1",TRUE
+"1555632_at",0.988164716416515,0.943575181009796,0.0715840337557721,-5.93718794403793,0.0271914077065656,"PIK3IP1","phosphoinositide-3-kinase interacting protein 1",TRUE
+"221757_at",0.998347572104896,0.991917194143665,0.0102453924485848,-5.9396323548034,0.00434061674223329,"PIK3IP1","phosphoinositide-3-kinase interacting protein 1",TRUE
+"242666_at",0.989482241798092,0.948201784668847,0.0657052059398618,-5.93758096316708,0.0267246223323561,"PIK3IP1-AS1","PIK3IP1 antisense RNA 1 (head to head)",TRUE
+"212249_at",0.547793752989355,0.0482619571678047,-2.09045153832929,-4.00956683217356,-1.60126518862326,"PIK3R1","phosphoinositide-3-kinase regulatory subunit 1",TRUE
+"212240_s_at",0.583523459663952,0.0646331608911731,-1.94453986764531,-4.24879526806161,-1.50562937534124,"PIK3R1","phosphoinositide-3-kinase regulatory subunit 1",TRUE
+"212239_at",0.593339168375633,0.0704621644596936,-1.90046086553938,-4.31874909615355,-1.1435658629162,"PIK3R1","phosphoinositide-3-kinase regulatory subunit 1",TRUE
+"1568629_s_at",0.625576683341349,0.0967650304314332,-1.73426194318553,-4.5721798125667,-0.807272734104114,"PIK3R2","phosphoinositide-3-kinase regulatory subunit 2",TRUE
+"207105_s_at",0.739189560382301,0.226325850638821,-1.24448255809566,-5.21225328393404,-0.549503467908902,"PIK3R2","phosphoinositide-3-kinase regulatory subunit 2",TRUE
+"229392_s_at",0.910165867297668,0.62631340203175,0.493790851022146,-5.82161592509853,0.374428767894234,"PIK3R2","phosphoinositide-3-kinase regulatory subunit 2",TRUE
+"211580_s_at",0.289452415034987,0.0049659977102792,-3.1193101599936,-2.06495528810419,-2.36563083819316,"PIK3R3","phosphoinositide-3-kinase regulatory subunit 3",TRUE
+"202743_at",0.390415895588582,0.0130450445849898,-2.6994741977952,-2.90329994063337,-2.17486394643458,"PIK3R3","phosphoinositide-3-kinase regulatory subunit 3",TRUE
+"216752_at",0.549127954108835,0.0486205473404823,2.08680999499555,-4.01567538893057,1.57020619001114,"PIK3R4","phosphoinositide-3-kinase regulatory subunit 4",TRUE
+"212740_at",0.620129049200068,0.0898318654893143,-1.77386055022232,-4.51332460641762,-0.528286450643247,"PIK3R4","phosphoinositide-3-kinase regulatory subunit 4",TRUE
+"216436_at",0.988404376556799,0.944650384050078,0.0702175963279771,-5.93728229601461,0.0578428654351333,"PIK3R4","phosphoinositide-3-kinase regulatory subunit 4",TRUE
+"227645_at",0.76912869907427,0.274656030752931,1.12012463537826,-5.34638159252876,0.768334332897642,"PIK3R5","phosphoinositide-3-kinase regulatory subunit 5",TRUE
+"227553_at",0.87579870142401,0.523742242506085,0.647845013762978,-5.73730334736325,0.40304129478261,"PIK3R5","phosphoinositide-3-kinase regulatory subunit 5",TRUE
+"220566_at",0.940044918888428,0.731315433982312,0.347742486077685,-5.88095646936462,0.098841424726638,"PIK3R5","phosphoinositide-3-kinase regulatory subunit 5",TRUE
+"1558770_a_at",0.556381379241158,0.0519190432054659,2.05439729849154,-4.0697418793886,0.536694046937531,"PIK3R6","phosphoinositide-3-kinase regulatory subunit 6",TRUE
+"213111_at",0.771159692311272,0.280312255567802,-1.10665891829329,-5.3601600782221,-0.377611412061173,"PIKFYVE","phosphoinositide kinase, FYVE-type zinc finger containing",TRUE
+"1557719_at",0.774230543658252,0.288681933582862,1.08709038632239,-5.37991907677526,0.725585282639242,"PIKFYVE","phosphoinositide kinase, FYVE-type zinc finger containing",TRUE
+"1553917_at",0.954387719376857,0.790210225030278,-0.269274428028822,-5.90442873563007,-0.173357192614541,"PIKFYVE","phosphoinositide kinase, FYVE-type zinc finger containing",TRUE
+"219788_at",0.783844746433788,0.306551265882142,-1.04663693302958,-5.41976679354191,-0.742188958201199,"PILRA","paired immunoglobin like type 2 receptor alpha",TRUE
+"222218_s_at",0.812896635201594,0.361704823245237,0.931361022466598,-5.52579591106458,0.292774400491161,"PILRA","paired immunoglobin like type 2 receptor alpha",TRUE
+"209193_at",0.643515428391208,0.114016532121515,1.64532520949443,-4.70072860738373,0.988304441422136,"PIM1","Pim-1 proto-oncogene, serine/threonine kinase",TRUE
+"204269_at",0.869082033398093,0.505971474046104,-0.676103728034848,-5.71945836298909,-0.252981703134504,"PIM2","Pim-2 proto-oncogene, serine/threonine kinase",TRUE
+"224739_at",0.677013732819214,0.144580972753182,-1.51233917635932,-4.88315041982648,-0.647890881937933,"PIM3","Pim-3 proto-oncogene, serine/threonine kinase",TRUE
+"202927_at",0.803706747165017,0.34229350663481,0.970458597760058,-5.49109642920707,0.399919191543844,"PIN1","peptidylprolyl cis/trans isomerase, NIMA-interacting 1",TRUE
+"207582_at",0.979588787486838,0.902837691604172,-0.123483344137054,-5.9322594036541,-0.0403996388118788,"PIN1P1","peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1",TRUE
+"204571_x_at",0.760439386481756,0.259432572035559,-1.15740447256194,-5.30746891032814,-0.429463536248944,"PIN4","peptidylprolyl cis/trans isomerase, NIMA-interacting 4",TRUE
+"214224_s_at",0.841471468936467,0.43253249497925,-0.799422769967529,-5.63311615450534,-0.309551959075868,"PIN4","peptidylprolyl cis/trans isomerase, NIMA-interacting 4",TRUE
+"214225_at",0.878774484192636,0.531898637449381,-0.635051761617647,-5.7451415876057,-0.225719521429314,"PIN4","peptidylprolyl cis/trans isomerase, NIMA-interacting 4",TRUE
+"204572_s_at",0.960198517898473,0.819754001886631,-0.230583691536906,-5.91382002893297,-0.0799059246249865,"PIN4","peptidylprolyl cis/trans isomerase, NIMA-interacting 4",TRUE
+"209018_s_at",0.819203514175924,0.376037898745298,0.903387016977097,-5.54981758229182,0.395269472967399,"PINK1","PTEN induced putative kinase 1",TRUE
+"209019_s_at",0.822010986888098,0.385670555014537,0.884980683102474,-5.56525405993738,0.44440266421495,"PINK1","PTEN induced putative kinase 1",TRUE
+"244486_at",0.734577729521114,0.218918891583415,1.26527202918389,-5.18864047719396,0.802370524427238,"PINK1-AS","PINK1 antisense RNA",TRUE
+"213556_at",0.280199223932988,0.00455804109298494,3.15578760737481,-1.99002535795852,2.31160821782352,"PINLYP","phospholipase A2 inhibitor and LY6/PLAUR domain containing",TRUE
+"223907_s_at",0.689168483917391,0.158173384806094,1.4605561594543,-4.95087175347949,0.423751994507237,"PINX1","PIN2/TERF1 interacting, telomerase inhibitor 1",TRUE
+"206509_at",0.623667408398064,0.0953167042349368,-1.7423283872565,-4.56027032637239,-2.58522997643887,"PIP","prolactin induced protein",TRUE
+"205570_at",0.582527497755585,0.0643630290615727,-1.94666627389615,-4.24539271725722,-0.544886323405641,"PIP4K2A","phosphatidylinositol-5-phosphate 4-kinase type 2 alpha",TRUE
+"212829_at",0.601886119917951,0.0770012044865347,-1.85466514574477,-4.39023741507431,-1.0542753197696,"PIP4K2A","phosphatidylinositol-5-phosphate 4-kinase type 2 alpha",TRUE
+"229713_at",0.769258076576208,0.275931392304701,-1.11707088250938,-5.34951922139019,-0.663866809415165,"PIP4K2A","phosphatidylinositol-5-phosphate 4-kinase type 2 alpha",TRUE
+"1553047_at",0.695643728007559,0.165007837375949,1.43587119715323,-4.98248108088238,0.438276379367192,"PIP4K2B","phosphatidylinositol-5-phosphate 4-kinase type 2 beta",TRUE
+"201080_at",0.830592576740524,0.403002796777436,-0.852601708342678,-5.59169253209032,-0.552855552270691,"PIP4K2B","phosphatidylinositol-5-phosphate 4-kinase type 2 beta",TRUE
+"1553048_a_at",0.991249206045988,0.959014195434561,-0.0519752144627816,-5.9383678028987,-0.0323811508275043,"PIP4K2B","phosphatidylinositol-5-phosphate 4-kinase type 2 beta",TRUE
+"201081_s_at",0.991689960875868,0.961260104061871,0.0491246515384981,-5.93850815306754,0.0332970003052395,"PIP4K2B","phosphatidylinositol-5-phosphate 4-kinase type 2 beta",TRUE
+"218942_at",0.767945391174396,0.270525864669842,-1.13008563624478,-5.33609434388238,-0.529046246953632,"PIP4K2C","phosphatidylinositol-5-phosphate 4-kinase type 2 gamma",TRUE
+"207391_s_at",0.765934384067577,0.266224408989011,-1.14057891816518,-5.32517042835227,-0.369425916206715,"PIP5K1A","phosphatidylinositol-4-phosphate 5-kinase type 1 alpha",TRUE
+"211205_x_at",0.805652838979402,0.344961885138431,-0.964996333071454,-5.49602268224367,-0.379793463706838,"PIP5K1A","phosphatidylinositol-4-phosphate 5-kinase type 1 alpha",TRUE
+"210256_s_at",0.947326616179611,0.760213845060638,-0.308992759312003,-5.8932870786781,-0.123894598684961,"PIP5K1A","phosphatidylinositol-4-phosphate 5-kinase type 1 alpha",TRUE
+"205632_s_at",0.533225267583674,0.0420930347469215,-2.15724279914946,-3.89632636261953,-1.0585467573244,"PIP5K1B","phosphatidylinositol-4-phosphate 5-kinase type 1 beta",TRUE
+"217477_at",0.895690630367785,0.57583161839807,0.567872374237884,-5.78382473402033,0.400335798452117,"PIP5K1B","phosphatidylinositol-4-phosphate 5-kinase type 1 beta",TRUE
+"212518_at",0.658906344891819,0.127040906032376,-1.58542011605007,-4.78438965631736,-0.493306166398138,"PIP5K1C","phosphatidylinositol-4-phosphate 5-kinase type 1 gamma",TRUE
+"243116_at",0.791353982620776,0.321874148210312,1.01325933238727,-5.45162050178258,0.595418764462293,"PIP5KL1","phosphatidylinositol-4-phosphate 5-kinase like 1",TRUE
+"221605_s_at",0.8920930097751,0.563944948931896,0.585777306828618,-5.77392293425986,0.174357928496098,"PIPOX","pipecolic acid and sarcosine oxidase",TRUE
+"207469_s_at",0.884766357907703,0.544388264941847,0.615665636796123,-5.75673241783222,0.349553646146948,"PIR","pirin",TRUE
+"206742_at",0.773754791548713,0.285280797716664,1.09499220596399,-5.37197810323528,0.804847852044372,"PIR-FIGF///FIGF","PIR-FIGF readthrough///c-fos induced growth factor",TRUE
+"232887_at",0.593904766176258,0.0707145866997245,-1.89862537861188,-4.32163786567015,-1.09654490338622,"PIRT","phosphoinositide interacting regulator of transient receptor potential channels",TRUE
+"223123_s_at",0.905934790589647,0.61240133176756,0.513911520721334,-5.81185991488451,0.398725784919376,"PITHD1","PITH domain containing 1",TRUE
+"223124_s_at",0.936318756756998,0.715983817798326,0.368519219115429,-5.8737527874056,0.138491742111301,"PITHD1","PITH domain containing 1",TRUE
+"229856_s_at",0.953706252864076,0.78658307757938,0.274052418226835,-5.90316879778044,0.132563114044516,"PITHD1","PITH domain containing 1",TRUE
+"201192_s_at",0.908466056355731,0.619446953069713,0.503695281931118,-5.81686102316961,0.201258120599499,"PITPNA","phosphatidylinositol transfer protein alpha",TRUE
+"201191_at",0.939682421466574,0.729491393420009,-0.350206004416982,-5.88012389750965,-0.138138193767746,"PITPNA","phosphatidylinositol transfer protein alpha",TRUE
+"201190_s_at",0.979877952746632,0.903978855720898,0.122025452353127,-5.93243360931572,0.0424164911035962,"PITPNA","phosphatidylinositol transfer protein alpha",TRUE
+"228972_at",0.915939421175188,0.645054344977848,-0.467007509483341,-5.83401162938908,-0.189761911810173,"PITPNA-AS1","PITPNA antisense RNA 1",TRUE
+"202522_at",0.966064677476069,0.841810500874898,-0.201934494056799,-5.91984173854896,-0.0720612817591046,"PITPNB","phosphatidylinositol transfer protein beta",TRUE
+"229414_at",0.245492559900582,0.00334507466165403,-3.2866246336556,-1.71906259006968,-2.31973616007027,"PITPNC1","phosphatidylinositol transfer protein, cytoplasmic 1",TRUE
+"219155_at",0.782471668844017,0.304796833875876,-1.05053309351964,-5.41598794251547,-0.726025064262215,"PITPNC1","phosphatidylinositol transfer protein, cytoplasmic 1",TRUE
+"227589_at",0.856857560656867,0.471110580715405,-0.733221419348979,-5.68117018014333,-0.462668625862805,"PITPNC1","phosphatidylinositol transfer protein, cytoplasmic 1",TRUE
+"1568949_at",0.877292551954694,0.526824807651183,-0.642997349374711,-5.74029111752141,-0.344330442019326,"PITPNC1","phosphatidylinositol transfer protein, cytoplasmic 1",TRUE
+"238649_at",0.94445268869026,0.750639077952177,-0.321775169774803,-5.88937876825914,-0.355989880522094,"PITPNC1","phosphatidylinositol transfer protein, cytoplasmic 1",TRUE
+"203826_s_at",0.662855903464759,0.130703943094093,1.5694978966474,-4.80621946324323,0.920540978751136,"PITPNM1","phosphatidylinositol transfer protein membrane associated 1",TRUE
+"1552924_a_at",0.595997098747707,0.0725488269855973,1.88545741057374,-4.34230491034766,1.51511804247723,"PITPNM2","phosphatidylinositol transfer protein membrane associated 2",TRUE
+"232950_s_at",0.732963666545614,0.217283572724275,1.26993441272038,-5.1832989372947,0.62953765377611,"PITPNM2","phosphatidylinositol transfer protein membrane associated 2",TRUE
+"1552923_a_at",0.774230543658252,0.287255447352023,1.09039630398068,-5.37660301155145,0.733382104149754,"PITPNM2","phosphatidylinositol transfer protein membrane associated 2",TRUE
+"230076_at",0.505411134618713,0.0329706168525308,2.27440807848906,-3.69239356601656,1.4503576984273,"PITPNM3","PITPNM family member 3",TRUE
+"221254_s_at",0.772988605474261,0.283634154604931,1.09884229742165,-5.36809038805023,0.381056515084735,"PITPNM3","PITPNM family member 3",TRUE
+"205273_s_at",0.26338132901877,0.00396043411216524,3.21537061285907,-1.86704041291532,0.978360577745287,"PITRM1","pitrilysin metallopeptidase 1",TRUE
+"239378_at",0.864044288984659,0.49068117410578,0.700867762574443,-5.70322140486406,0.479863059410667,"PITRM1","pitrilysin metallopeptidase 1",TRUE
+"1557610_at",0.878278790222455,0.531155737089621,-0.636212558922398,-5.74443658324862,-0.261403074918237,"PITRM1-AS1","PITRM1 antisense RNA 1",TRUE
+"209587_at",0.920491425364243,0.661536245363412,-0.443736489043208,-5.84423213904273,-0.59720129226412,"PITX1","paired like homeodomain 1",TRUE
+"208502_s_at",0.93079617675941,0.693206941407708,-0.399696664457023,-5.86216967398039,-0.380936725151994,"PITX1","paired like homeodomain 1",TRUE
+"207558_s_at",0.640084004961683,0.110819116432872,1.66090579393681,-4.67857897577656,1.52432716351445,"PITX2","paired like homeodomain 2",TRUE
+"208277_at",0.398439157867667,0.013857263587818,2.67255927816184,-2.9552748076734,1.07692615413211,"PITX3","paired like homeodomain 3",TRUE
+"214868_at",0.607896769589432,0.0810973760838649,-1.82767672609464,-4.43178685794804,-0.993660782848048,"PIWIL1","piwi like RNA-mediated gene silencing 1",TRUE
+"220686_s_at",0.729243033517027,0.2113904497158,-1.28696334098849,-5.16364707629084,-0.656478788420042,"PIWIL2","piwi like RNA-mediated gene silencing 2",TRUE
+"239303_at",0.805168768064335,0.344437599703927,0.966067281973534,-5.49505882691987,0.484864776089275,"PIWIL2","piwi like RNA-mediated gene silencing 2",TRUE
+"217421_at",0.932091525948902,0.69966404785658,-0.390818381900688,-5.86556252255114,-0.129919095039166,"PIWIL2","piwi like RNA-mediated gene silencing 2",TRUE
+"230480_at",0.75959865506602,0.257478589379763,1.16230535150896,-5.3022700748324,1.03634193122916,"PIWIL4","piwi like RNA-mediated gene silencing 4",TRUE
+"218667_at",0.567292616148537,0.057256609002897,2.0056511255942,-4.1500044899303,0.765061047537369,"PJA1","praja ring finger ubiquitin ligase 1",TRUE
+"201133_s_at",0.846506765330126,0.444686815384333,-0.778192466878065,-5.6489535800045,-0.295181640890554,"PJA2","praja ring finger ubiquitin ligase 2",TRUE
+"1553004_at",0.596382916302699,0.0728124967798129,1.88358854023053,-4.34522991807735,1.09197412878055,"PKD1L1","polycystin 1 like 1, transient receptor potential channel interacting",TRUE
+"1563465_at",0.946277807642742,0.756710714325669,-0.313663268004894,-5.89187722906395,-0.28228521591253,"PKD1L1","polycystin 1 like 1, transient receptor potential channel interacting",TRUE
+"1554371_at",0.280199223932988,0.00462623419719849,3.14947584549082,-2.0030108608546,1.73351947344,"PKD1L2","polycystin 1 like 2 (gene/pseudogene)",TRUE
+"1559261_a_at",0.839519981963042,0.42715786525437,0.808928229978745,-5.62589537611088,0.23499169741906,"PKD1L2","polycystin 1 like 2 (gene/pseudogene)",TRUE
+"1561849_at",0.899331416659389,0.590018593549063,0.54674465648893,-5.79512535232394,0.443786000275526,"PKD1L2","polycystin 1 like 2 (gene/pseudogene)",TRUE
+"244444_at",0.986142013747583,0.931888421111959,0.0864459050682533,-5.93604436470907,0.0702641987809884,"PKD1L2","polycystin 1 like 2 (gene/pseudogene)",TRUE
+"214682_at",0.721094750464234,0.197324584908994,1.32914716468505,-5.11401054819936,0.770012476016422,"PKD1P1","polycystin 1, transient receptor potential channel interacting pseudogene 1",TRUE
+"203688_at",0.903383391791809,0.603508762879394,0.526885587516406,-5.80536774203852,0.518714911138883,"PKD2","polycystin 2, transient receptor potential cation channel",TRUE
+"221061_at",0.653206225743412,0.122564739529325,1.60540368963859,-4.75674853195771,1.10666560590522,"PKD2L1","polycystin 2 like 1, transient receptor potential cation channel",TRUE
+"224226_at",0.831875452294783,0.407667633039356,-0.844040765610586,-5.59852941245595,-0.747377316149987,"PKD2L2","polycystin 2 like 2, transient receptor potential cation channel",TRUE
+"221118_at",0.976371465776674,0.886773937708551,0.144036201548689,-5.92958370993383,0.047737110668109,"PKD2L2","polycystin 2 like 2, transient receptor potential cation channel",TRUE
+"225380_at",0.835289077598304,0.41451817055959,-0.831580902630913,-5.60836487991396,-0.90001810430654,"PKDCC","protein kinase domain containing, cytoplasmic",TRUE
+"220548_at",0.768882610729436,0.274259404929783,-1.12107643358436,-5.34540210177813,-0.582618149338528,"PKDREJ","polycystin (PKD) family receptor for egg jelly",TRUE
+"241694_at",0.722937902375896,0.199596607814884,1.32217806200302,-5.12230413650084,0.514588691115317,"PKHD1","polycystic kidney and hepatic disease 1 (autosomal recessive)",TRUE
+"1553003_at",0.7800665680871,0.301403460455359,1.05811433668624,-5.40859883181312,0.766794139200974,"PKHD1","polycystic kidney and hepatic disease 1 (autosomal recessive)",TRUE
+"244410_at",0.917102138198416,0.649511669652038,-0.460688823785152,-5.83683738321207,-0.15964925574385,"PKHD1","polycystic kidney and hepatic disease 1 (autosomal recessive)",TRUE
+"230673_at",0.974982245454858,0.877604804126428,-0.155795661366522,-5.92786825442993,-0.0914681906348347,"PKHD1L1","polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1",TRUE
+"214717_at",0.8877101263145,0.552722885033064,-0.602860285262649,-5.76419864239558,-0.440378953798428,"PKI55","DKFZp434H1419",TRUE
+"204612_at",0.578925607036084,0.0618594409609822,1.96675774204306,-4.21311824927629,2.43788392538624,"PKIA","protein kinase (cAMP-dependent, catalytic) inhibitor alpha",TRUE
+"226864_at",0.717937808890208,0.193683951840773,1.3404463471184,-5.10048605074282,1.68224642616757,"PKIA","protein kinase (cAMP-dependent, catalytic) inhibitor alpha",TRUE
+"1569218_at",0.880471324868787,0.535899858234723,-0.628814792251971,-5.74890837141686,-0.667766219004152,"PKIA-AS1","PKIA antisense RNA 1",TRUE
+"223551_at",0.675476329277723,0.141803700181979,-1.52340569726349,-4.86843267233334,-2.11303831846457,"PKIB","protein kinase (cAMP-dependent, catalytic) inhibitor beta",TRUE
+"231120_x_at",0.88020017258149,0.535505043450498,-0.629429096759279,-5.74853895382831,-1.03000782927388,"PKIB","protein kinase (cAMP-dependent, catalytic) inhibitor beta",TRUE
+"202732_at",0.899046682581382,0.58906551152433,0.548156054714243,-5.79438340074363,0.61569574205774,"PKIG","protein kinase (cAMP-dependent, catalytic) inhibitor gamma",TRUE
+"222078_at",0.673356287352323,0.139142088958864,-1.53417957587926,-4.85402209573121,-0.761702327107905,"PKLR","pyruvate kinase, liver and RBC",TRUE
+"207858_s_at",0.740681080735184,0.230979042969693,1.23168640315753,-5.22661995540298,0.562739383011514,"PKLR","pyruvate kinase, liver and RBC",TRUE
+"210451_at",0.880313004315556,0.535739092923563,-0.629064902540947,-5.7487580072266,-0.320464820978175,"PKLR","pyruvate kinase, liver and RBC",TRUE
+"213700_s_at",0.94740898733987,0.760665015569193,0.30839175318146,-5.89346697787398,0.117161498867437,"PKM","pyruvate kinase, muscle",TRUE
+"201251_at",0.975398143273847,0.882046723655962,0.150096173182583,-5.92871645665173,0.0587894188067484,"PKM","pyruvate kinase, muscle",TRUE
+"204267_x_at",0.767727587789514,0.269910592806489,-1.13157903614398,-5.33454509460942,-0.323514716185993,"PKMYT1","protein kinase, membrane associated tyrosine/threonine 1",TRUE
+"202161_at",0.868397087637799,0.503469267250936,0.68012694450387,-5.71685844791606,0.335356064341893,"PKN1","protein kinase N1",TRUE
+"212629_s_at",0.419321539441471,0.0173097158576936,2.57260494885421,-3.1461034326075,1.07241521574812,"PKN2","protein kinase N2",TRUE
+"212628_at",0.632216562924782,0.103398671479439,1.69858278235056,-4.62436250557587,0.603362501413818,"PKN2","protein kinase N2",TRUE
+"210969_at",0.656429846208987,0.124538578778707,1.59651789050291,-4.76907257100685,0.877636296704392,"PKN2","protein kinase N2",TRUE
+"226299_at",0.92092479537116,0.663621692049901,0.440809944341292,-5.84548119925867,0.35149912182777,"PKN3","protein kinase N3",TRUE
+"204196_x_at",0.221141813634458,0.0027099225447661,-3.37500899176856,-1.53426419611218,-1.30501677169661,"PKNOX1","PBX/knotted 1 homeobox 1",TRUE
+"216004_s_at",0.865345395265289,0.495052222089602,0.693744135614701,-5.7079492681288,0.268437571379276,"PKNOX1","PBX/knotted 1 homeobox 1",TRUE
+"204195_s_at",0.899808883319249,0.592281357484674,0.543398265719222,-5.79687707369862,0.315213489809449,"PKNOX1","PBX/knotted 1 homeobox 1",TRUE
+"54051_at",0.954387719376857,0.790178542345068,0.269316135307438,-5.90441783277728,0.0779503376626813,"PKNOX1","PBX/knotted 1 homeobox 1",TRUE
+"221883_at",0.986889306520757,0.938986239498662,-0.0774175600258452,-5.9367646998728,-0.0202385866298389,"PKNOX1","PBX/knotted 1 homeobox 1",TRUE
+"219046_s_at",0.645740804644555,0.116704807648627,1.63250756226746,-4.71883046382881,1.36122587305052,"PKNOX2","PBX/knotted 1 homeobox 2",TRUE
+"63305_at",0.778537373775587,0.298571040755857,1.06448897758685,-5.40234886986142,0.344979459071106,"PKNOX2","PBX/knotted 1 homeobox 2",TRUE
+"222171_s_at",0.782042580063933,0.303702798005288,-1.05297073521283,-5.41361728133746,-0.775554634789287,"PKNOX2","PBX/knotted 1 homeobox 2",TRUE
+"222185_at",0.91202803207519,0.631286699240959,-0.486648372007319,-5.82498763108824,-0.18299638759387,"PKNOX2","PBX/knotted 1 homeobox 2",TRUE
+"221854_at",0.571267581958301,0.0591485282389747,1.98934062553177,-4.17657347989155,3.46344777814102,"PKP1","plakophilin 1",TRUE
+"205724_at",0.671298718565642,0.137379938126331,1.5414061911625,-4.84431100159739,1.39422572665651,"PKP1","plakophilin 1",TRUE
+"207717_s_at",0.554383599468784,0.0507532683370922,2.06563653571269,-4.05105644816233,1.90738559699342,"PKP2","plakophilin 2",TRUE
+"214154_s_at",0.584247456664678,0.0648736407756975,1.94265345581609,-4.25181165964751,1.64819055569752,"PKP2","plakophilin 2",TRUE
+"209873_s_at",0.905384410285554,0.611140686712367,0.515745297814003,-5.81095187045501,0.227637676179572,"PKP3","plakophilin 3",TRUE
+"209872_s_at",0.955892698633978,0.800103924487057,0.25627373266021,-5.90774554256435,0.087618814748236,"PKP3","plakophilin 3",TRUE
+"201929_s_at",0.746535697909741,0.238343317262314,-1.21182892269489,-5.24866062018053,-0.365739888034488,"PKP4","plakophilin 4",TRUE
+"214874_at",0.774230543658252,0.289820200761397,-1.0844608553768,-5.38255026888044,-0.712777763522805,"PKP4","plakophilin 4",TRUE
+"201928_at",0.823073978212882,0.388893784570876,-0.878888904812145,-5.5702980798226,-0.283406263955529,"PKP4","plakophilin 4",TRUE
+"201927_s_at",0.893600768892136,0.568541764079901,-0.578830485065035,-5.77780000433216,-0.155243573926979,"PKP4","plakophilin 4",TRUE
+"240379_at",0.9340157600858,0.707694591755099,-0.379821028410633,-5.8696610315415,-0.268176172575433,"PKP4","plakophilin 4",TRUE
+"219584_at",0.86921531641038,0.506233107874284,0.675683703066574,-5.71972894415121,0.518380792073275,"PLA1A","phospholipase A1 member A",TRUE
+"221027_s_at",0.778397054392363,0.29824510463854,-1.06522529168477,-5.40162479004824,-0.379522230620355,"PLA2G12A","phospholipase A2 group XIIA",TRUE
+"223373_s_at",0.860085676417428,0.47919817885242,-0.719758004603606,-5.690461404239,-0.217464994534884,"PLA2G12A","phospholipase A2 group XIIA",TRUE
+"228084_at",0.877339406737153,0.527179612465975,-0.642440376458103,-5.74063301686873,-0.26850085391124,"PLA2G12A","phospholipase A2 group XIIA",TRUE
+"242323_at",0.913677111217212,0.638128471311211,-0.4768641438993,-5.82952845054732,-0.19053968438844,"PLA2G12A","phospholipase A2 group XIIA",TRUE
+"224411_at",0.628942124201448,0.0999635493243819,-1.71680687470381,-4.59781007319064,-0.963444951149173,"PLA2G12B","phospholipase A2 group XIIB",TRUE
+"231009_at",0.62986301194198,0.100917415881043,-1.71169361321711,-4.60528150059084,-0.991898538389966,"PLA2G12B","phospholipase A2 group XIIB",TRUE
+"204458_at",0.977930820766623,0.893422600200144,0.135522344712563,-5.93074188757543,0.0490403802372317,"PLA2G15","phospholipase A2 group XV",TRUE
+"209581_at",0.63885810443071,0.109742209726808,1.66623878633283,-4.67096094840799,2.32406553111625,"PLA2G16","phospholipase A2 group XVI",TRUE
+"235110_at",0.758966211371161,0.256421897788508,1.16496718643998,-5.29943833790927,0.446823609427982,"PLA2G16","phospholipase A2 group XVI",TRUE
+"206311_s_at",0.423421354964585,0.0177716572743545,2.56068046702478,-3.16862961550524,1.58290137739343,"PLA2G1B","phospholipase A2 group IB",TRUE
+"203649_s_at",0.855021564299387,0.467157928393779,-0.739850911697361,-5.67653504472037,-1.04196413737779,"PLA2G2A","phospholipase A2 group IIA",TRUE
+"220423_at",0.935763424099422,0.713678994449416,-0.371656724993024,-5.87262909878397,-0.258334622198485,"PLA2G2D","phospholipase A2 group IID",TRUE
+"221389_at",0.874474734833648,0.520510861224608,0.652943530066192,-5.73413772285855,0.398614095697003,"PLA2G2E","phospholipase A2 group IIE",TRUE
+"221416_at",0.525544706916339,0.0394002332629186,2.18921267392484,-3.84133479642212,1.14998286762487,"PLA2G2F","phospholipase A2 group IIF",TRUE
+"220780_at",0.932097892023912,0.700697747498893,-0.389400066174891,-5.86609757824358,-0.368973250297739,"PLA2G3","phospholipase A2 group III",TRUE
+"210145_at",0.285319386651973,0.00483229700989869,3.13093552491445,-2.04110604008106,4.37600881966442,"PLA2G4A","phospholipase A2 group IVA",TRUE
+"219095_at",0.894729774938685,0.571813180870498,-0.573904116030338,-5.78052230544011,-0.517498534422505,"PLA2G4B///JMJD7-PLA2G4B","phospholipase A2 group IVB///JMJD7-PLA2G4B readthrough",TRUE
+"60528_at",0.957610494018084,0.809840729846019,0.243523132669773,-5.91084013217951,0.0785294703858437,"PLA2G4B///JMJD7-PLA2G4B","phospholipase A2 group IVB///JMJD7-PLA2G4B readthrough",TRUE
+"209785_s_at",0.76711764189372,0.268994352243172,-1.13380758571981,-5.33222984432568,-1.07937782781355,"PLA2G4C","phospholipase A2 group IVC",TRUE
+"1554810_at",0.79814964343286,0.332417833984284,-0.990932015838704,-5.4724066121093,-0.431997131455311,"PLA2G4C","phospholipase A2 group IVC",TRUE
+"1554914_at",0.638134354959023,0.109338340967602,1.66825019791383,-4.66808288077446,0.922787961660463,"PLA2G4D","phospholipase A2 group IVD",TRUE
+"1557864_x_at",0.690381347688918,0.160099635068465,1.45351307243811,-4.9599351901059,1.20277067223308,"PLA2G4E-AS1","PLA2G4E antisense RNA 1",TRUE
+"1557863_at",0.77547560202111,0.29270570827976,1.07782811170727,-5.38916193757449,0.718872783109364,"PLA2G4E-AS1","PLA2G4E antisense RNA 1",TRUE
+"235958_at",0.901952802800924,0.600279077975675,-0.531620266018905,-5.80295927854188,-0.222713493254669,"PLA2G4F","phospholipase A2 group IVF",TRUE
+"206178_at",0.405141741421442,0.0151384424064701,-2.63298688907322,-3.03124533812411,-1.36909724760717,"PLA2G5","phospholipase A2 group V",TRUE
+"215871_at",0.913221029035633,0.635884295338763,-0.48006822944591,-5.82805137883229,-0.294944411105289,"PLA2G5","phospholipase A2 group V",TRUE
+"215870_s_at",0.968066640321622,0.849673443268364,-0.191764236774408,-5.92178830935415,-0.167857962200035,"PLA2G5","phospholipase A2 group V",TRUE
+"204691_x_at",0.812302873476553,0.357974165753173,0.938763183477434,-5.51932682714593,0.310166153913462,"PLA2G6","phospholipase A2 group VI",TRUE
+"215938_s_at",0.901788521024914,0.599375565309727,0.53294700439829,-5.8022806247687,0.146789206060164,"PLA2G6","phospholipase A2 group VI",TRUE
+"210647_x_at",0.983567332578112,0.91983527460941,0.101794668707036,-5.93463771726653,0.0336634211567848,"PLA2G6","phospholipase A2 group VI",TRUE
+"206214_at",0.501591596209182,0.0321972789521526,2.28565807328765,-3.67247285079137,1.79644984945633,"PLA2G7","phospholipase A2 group VII",TRUE
+"240039_at",0.767965891104819,0.270993785476091,-1.12895155482858,-5.33726962987423,-0.512974832362313,"PLA2R1","phospholipase A2 receptor 1",TRUE
+"207415_at",0.819018525257656,0.375297703805565,0.904814172461674,-5.54860842490833,0.746684362874754,"PLA2R1","phospholipase A2 receptor 1",TRUE
+"235746_s_at",0.841813886364358,0.434094574221183,0.796673850863381,-5.63518940435795,0.911562268736286,"PLA2R1","phospholipase A2 receptor 1",TRUE
+"210194_at",0.93076292027359,0.693161904328177,-0.399758702889158,-5.86214570183391,-0.37550040901216,"PLA2R1","phospholipase A2 receptor 1",TRUE
+"209532_at",0.73957587762701,0.227894274279502,-1.24014724684365,-5.21713500304723,-0.66919333281659,"PLAA","phospholipase A2 activating protein",TRUE
+"235394_at",0.916042382946954,0.645716717013771,-0.466067318119399,-5.83443447591186,-0.201603032437426,"PLAA","phospholipase A2 activating protein",TRUE
+"209533_s_at",0.967777603239069,0.848441078095556,-0.193356834386823,-5.92149010565818,-0.0790545887806697,"PLAA","phospholipase A2 activating protein",TRUE
+"219702_at",0.761917987439165,0.261302682806983,-1.15273947844143,-5.31239960291367,-0.564862125088065,"PLAC1","placenta specific 1",TRUE
+"227519_at",0.89390639630277,0.569756059933926,0.577000216358483,-5.77881403757351,0.422996451334977,"PLAC4","placenta specific 4",TRUE
+"214750_at",0.899798994481376,0.591600408183885,0.544404656665554,-5.79635136124016,0.383650859938756,"PLAC4","placenta specific 4",TRUE
+"231454_at",0.958794064221941,0.813585762014878,-0.238630000541199,-5.91198601974323,-0.180855913932769,"PLAC4","placenta specific 4",TRUE
+"219014_at",0.581852599439475,0.0641260759057509,1.94853799590859,-4.24239558979568,2.86228122056185,"PLAC8","placenta specific 8",TRUE
+"237783_at",0.98661350081953,0.937693350829192,0.0790615862602927,-5.93663943701019,0.0212771606971245,"PLAC8L1","PLAC8 like 1",TRUE
+"230246_at",0.610455440146151,0.0829280715353513,1.81599576567102,-4.44963457918375,1.08480589236284,"PLAC9","placenta specific 9",TRUE
+"227419_x_at",0.923004698880603,0.670066803986628,-0.431789937232984,-5.84927992723301,-0.266072531529732,"PLAC9","placenta specific 9",TRUE
+"205372_at",0.532079878820242,0.0418224939477475,2.16036976093315,-3.89096985011249,2.89161076491953,"PLAG1","PLAG1 zinc finger",TRUE
+"207943_x_at",0.55937703282623,0.053190564602186,2.04239284260447,-4.08962573390123,2.41276891496774,"PLAGL1","PLAG1 like zinc finger 1",TRUE
+"209318_x_at",0.56861088242915,0.0580956042125958,1.99835988716788,-4.16189953247947,2.80716503897646,"PLAGL1","PLAG1 like zinc finger 1",TRUE
+"207002_s_at",0.62986301194198,0.101070856631915,1.71087493031657,-4.60647619988739,2.89075233514467,"PLAGL1","PLAG1 like zinc finger 1",TRUE
+"202924_s_at",0.725225714005638,0.204031493970457,1.30875108996054,-5.1381791592695,0.462955461125969,"PLAGL2","PLAG1 like zinc finger 2",TRUE
+"202925_s_at",0.831199595271435,0.405360878067079,0.848266274212823,-5.59516290878041,0.257057588692424,"PLAGL2","PLAG1 like zinc finger 2",TRUE
+"201860_s_at",0.48580305784244,0.0285518107268642,2.34227244583388,-3.57135840825161,4.06671600781109,"PLAT","plasminogen activator, tissue type",TRUE
+"205479_s_at",0.0985170196189519,0.000441457152384878,4.12294275838359,0.0647002088043873,5.50905227649532,"PLAU","plasminogen activator, urokinase",TRUE
+"211668_s_at",0.130668376232398,0.00080301004872585,3.87819267097921,-0.463081630084575,5.25118791506482,"PLAU","plasminogen activator, urokinase",TRUE
+"210845_s_at",0.289816987027404,0.00500918249183168,3.11561971640995,-2.07252002934376,2.2201219222509,"PLAUR","plasminogen activator, urokinase receptor",TRUE
+"211924_s_at",0.344817137069397,0.0087158167979864,2.87699258653843,-2.55475360258021,2.15081064517578,"PLAUR","plasminogen activator, urokinase receptor",TRUE
+"214866_at",0.470885186348082,0.0255740208203305,2.39368958135302,-3.47830924912552,1.58692497204286,"PLAUR","plasminogen activator, urokinase receptor",TRUE
+"235703_at",0.848487435987772,0.448895245969498,0.770924324121677,-5.65428314052888,0.456581318002365,"PLB1","phospholipase B1",TRUE
+"1553310_at",0.954577684533304,0.792084423387259,0.266808087152867,-5.9050704892531,0.21731730043641,"PLB1","phospholipase B1",TRUE
+"218454_at",0.541849190341655,0.0453083320884657,2.12140679425711,-3.95736516271701,2.50124602215058,"PLBD1","phospholipase B domain containing 1",TRUE
+"228845_at",0.906507435035949,0.614240725275542,-0.511239072804668,-5.81317760374086,-0.342943525522625,"PLBD2","phospholipase B domain containing 2",TRUE
+"227853_at",0.970573392456845,0.860053068757405,-0.178370234110848,-5.92419897964409,-0.0676439792305494,"PLBD2","phospholipase B domain containing 2",TRUE
+"213222_at",0.469204788139811,0.0251529809609106,-2.40140125300025,-3.46425631402321,-3.17875251554618,"PLCB1","phospholipase C beta 1",TRUE
+"211925_s_at",0.859465912277024,0.476649573777262,-0.723986192029509,-5.68756112048642,-0.59171312237543,"PLCB1","phospholipase C beta 1",TRUE
+"215687_x_at",0.910888708415045,0.628419230776467,-0.490763373929314,-5.82305094816108,-0.235370781492279,"PLCB1","phospholipase C beta 1",TRUE
+"210388_at",0.657015752622694,0.125427972251117,1.59255235495713,-4.77455534183637,0.629509191845708,"PLCB2","phospholipase C beta 2",TRUE
+"204046_at",0.835952408568777,0.415976825487385,-0.828944752566442,-5.61042825517893,-0.362651932668533,"PLCB2","phospholipase C beta 2",TRUE
+"213384_x_at",0.6708432030569,0.136681776406244,1.5442904988172,-4.84042499032533,0.473762013078396,"PLCB3","phospholipase C beta 3",TRUE
+"203895_at",0.712975827977365,0.187544334563491,-1.359885076438,-5.07699458091424,-2.08724465243395,"PLCB4","phospholipase C beta 4",TRUE
+"203896_s_at",0.808257777979515,0.350902840356721,-0.952937508879727,-5.50680814792579,-1.43876497938939,"PLCB4","phospholipase C beta 4",TRUE
+"205125_at",0.595019326272843,0.0718598602147342,1.89036894457676,-4.33460806679062,0.778576774613935,"PLCD1","phospholipase C delta 1",TRUE
+"1552476_s_at",0.979588787486838,0.902026588818131,0.124519733263469,-5.93213430765932,0.0714913909618478,"PLCD3","phospholipase C delta 3",TRUE
+"234971_x_at",0.994995652507262,0.976451517712477,-0.0298530594866029,-5.93924941689615,-0.0280499649416521,"PLCD3","phospholipase C delta 3",TRUE
+"224505_s_at",0.853460708803218,0.461968595164821,-0.748605303011113,-5.67035364350683,-0.542269344738875,"PLCD4","phospholipase C delta 4",TRUE
+"1566739_at",0.432151440378733,0.0192395600482359,2.52462408115575,-3.23641943006822,0.92698223267889,"PLCE1","phospholipase C epsilon 1",TRUE
+"205112_at",0.73957587762701,0.228187318655907,1.23933975865669,-5.21804264453298,1.7584507033318,"PLCE1","phospholipase C epsilon 1",TRUE
+"214159_at",0.768852835478002,0.274021831365466,1.12164702933002,-5.3448145515816,0.761519849260431,"PLCE1","phospholipase C epsilon 1",TRUE
+"1566740_at",0.839781238235762,0.42851688849143,0.806517704158721,-5.62773410705604,0.345164664291048,"PLCE1","phospholipase C epsilon 1",TRUE
+"205111_s_at",0.85432490921773,0.465030884741269,0.743432200307586,-5.67401465782144,0.659602593235614,"PLCE1","phospholipase C epsilon 1",TRUE
+"1563103_at",0.7717895132349,0.28150742222265,-1.10383892541339,-5.36302684494084,-0.3861960573883,"PLCE1-AS2","PLCE1 antisense RNA 2",TRUE
+"1562826_at",0.810375880424165,0.354350229529138,0.946003437340528,-5.51295376980956,0.482355108472428,"PLCE1-AS2","PLCE1 antisense RNA 2",TRUE
+"202789_at",0.55937703282623,0.0537433776799627,-2.03725345374539,-4.09811505121896,-0.792336884065971,"PLCG1","phospholipase C gamma 1",TRUE
+"216551_x_at",0.785797192933884,0.311318526839331,-1.03612909491948,-5.42989526374469,-0.343507139088805,"PLCG1","phospholipase C gamma 1",TRUE
+"1558354_s_at",0.725181883744124,0.203751537651666,1.30959192407164,-5.13718904105128,0.722100008520154,"PLCG1-AS1","PLCG1 antisense RNA 1",TRUE
+"1563263_at",0.673322568613087,0.138948951486392,1.5349679477576,-4.85296444380619,0.72888784479012,"PLCG2","phospholipase C gamma 2",TRUE
+"204613_at",0.79705794499562,0.330109316688665,0.995778088095266,-5.46793077293725,0.458694854142392,"PLCG2","phospholipase C gamma 2",TRUE
+"230917_at",0.955730092376044,0.797720614682729,0.259401281608848,-5.90696251731659,0.222554451095775,"PLCG2","phospholipase C gamma 2",TRUE
+"1557993_at",0.97580093550434,0.884336593523662,0.147160009117672,-5.92914110968881,0.103531277823588,"PLCG2","phospholipase C gamma 2",TRUE
+"214745_at",0.657015752622694,0.125672465568137,-1.59146633834742,-4.77605502139983,-1.11527783019284,"PLCH1","phospholipase C eta 1",TRUE
+"216634_at",0.793654340638017,0.325450132209733,1.00563066059054,-5.45876981690935,0.793280315483713,"PLCH1","phospholipase C eta 1",TRUE
+"216633_s_at",0.843850838418098,0.439928760857139,0.786460542175217,-5.64283346820655,0.57243090290383,"PLCH1","phospholipase C eta 1",TRUE
+"1561531_at",0.778397054392363,0.298183138862993,1.06536534198186,-5.40148701600918,0.491511186764988,"PLCH1-AS1","PLCH1 antisense RNA 1",TRUE
+"206080_at",0.967457899578013,0.847540895729084,-0.194520472137421,-5.92127066821812,-0.124881998316298,"PLCH2","phospholipase C eta 2",TRUE
+"241859_at",0.76912869907427,0.274949354807354,1.11942137949372,-5.34710483655386,0.967684675818703,"PLCL1","phospholipase C like 1",TRUE
+"205934_at",0.843087230275826,0.437086799811823,-0.791425188170467,-5.63912931556657,-0.451119571736084,"PLCL1","phospholipase C like 1",TRUE
+"213309_at",0.156653457988943,0.0012027484161011,3.71214577354539,-0.819340070292172,4.01212716626292,"PLCL2","phospholipase C like 2",TRUE
+"216218_s_at",0.232037111848437,0.00297187884309975,3.33633797571182,-1.61528013218206,3.59199100903914,"PLCL2","phospholipase C like 2",TRUE
+"216217_at",0.730819267705703,0.213429148774915,1.28103132540334,-5.17051811261712,0.767735527851746,"PLCL2","phospholipase C like 2",TRUE
+"222795_s_at",0.585850686899876,0.065834928624623,-1.93517378619318,-4.26375193294411,-1.04486299558649,"PLCXD1","phosphatidylinositol specific phospholipase C X domain containing 1",TRUE
+"218951_s_at",0.601115828839805,0.0767899214271202,-1.85609081347255,-4.38803049804089,-0.746860880058774,"PLCXD1","phosphatidylinositol specific phospholipase C X domain containing 1",TRUE
+"235230_at",0.219371608436167,0.00268011803643847,3.37963773982242,-1.52455090639694,2.50763588404416,"PLCXD2","phosphatidylinositol specific phospholipase C X domain containing 2",TRUE
+"1553281_at",0.784918343662568,0.309741305143264,1.03959289510961,-5.42656668328139,0.68702474915203,"PLCXD2","phosphatidylinositol specific phospholipase C X domain containing 2",TRUE
+"230081_at",0.293201849358402,0.00518566416697897,3.10085052928886,-2.102764212479,4.83880061000988,"PLCXD3","phosphatidylinositol specific phospholipase C X domain containing 3",TRUE
+"239270_at",0.30050033261608,0.0056788425576629,3.06201213638338,-2.18206314191395,3.81352744330049,"PLCXD3","phosphatidylinositol specific phospholipase C X domain containing 3",TRUE
+"231425_at",0.762225611287473,0.261655416991818,1.15186235112801,-5.3133247336716,0.937864602770279,"PLCZ1","phospholipase C zeta 1",TRUE
+"205203_at",0.296090407530139,0.00529409470286017,3.09201496226118,-2.12083442267268,1.33767942964958,"PLD1","phospholipase D1",TRUE
+"215723_s_at",0.380084968057051,0.0117654576620942,2.74527110970621,-2.8143147050241,2.56450245241319,"PLD1","phospholipase D1",TRUE
+"226636_at",0.410263142293979,0.0158693951943273,2.61179965695658,-3.0716961669626,2.91413558654247,"PLD1","phospholipase D1",TRUE
+"177_at",0.415568369766277,0.0168431551422418,2.58495512595358,-3.12271796419718,1.32508249152222,"PLD1","phospholipase D1",TRUE
+"232530_at",0.610404195568275,0.0827980313370644,1.81681809307136,-4.44838081396395,1.96884398692482,"PLD1","phospholipase D1",TRUE
+"1557126_a_at",0.655745626967443,0.124164929323468,1.59819092275869,-4.76675624482049,1.0802583468844,"PLD1","phospholipase D1",TRUE
+"215724_at",0.845542514511094,0.442806014046569,0.781454241413407,-5.64654646335588,0.596707142535909,"PLD1","phospholipase D1",TRUE
+"209643_s_at",0.591272702915983,0.0685411319813718,1.91462171899084,-4.29639680572869,0.509419978034986,"PLD2","phospholipase D2",TRUE
+"201050_at",0.723655063748891,0.200579906817937,-1.31918113061301,-5.12585933664859,-0.457614502673529,"PLD3","phospholipase D family member 3",TRUE
+"1566433_at",0.744931128252932,0.236663926697982,1.21631604553217,-5.24370727660267,0.472350981161651,"PLD4","phospholipase D family member 4",TRUE
+"235802_at",0.861659105448003,0.482801406062672,-0.713802494941949,-5.69451911351239,-0.416400295406818,"PLD4","phospholipase D family member 4",TRUE
+"242173_at",0.904832003218088,0.610030789800957,-0.517361275295331,-5.81014906250447,-0.457910316556129,"PLD5","phospholipase D family member 5",TRUE
+"1563933_a_at",0.994587495898891,0.974995895842501,0.0316990186919624,-5.9391940780332,0.0193933540043556,"PLD5","phospholipase D family member 5",TRUE
+"244430_at",0.726636642789909,0.205835081320535,1.30335550294457,-5.14451988333374,0.42270989194606,"PLD6","phospholipase D family member 6",TRUE
+"227037_at",0.898813992560978,0.588759664521263,0.548609215426561,-5.79414478664938,0.162795868329127,"PLD6///FLCN","phospholipase D family member 6///folliculin",TRUE
+"216971_s_at",0.591331966259927,0.068777805724523,1.91285841042417,-4.29918639868208,1.1943237083209,"PLEC","plectin",TRUE
+"201373_at",0.713633547141264,0.188377560034302,1.35721787438057,-5.08023460031475,0.719341118928547,"PLEC","plectin",TRUE
+"203471_s_at",0.67842163564685,0.145801727701418,1.50752989475753,-4.88951973033751,0.619389270205486,"PLEK","pleckstrin",TRUE
+"203470_s_at",0.9116561917482,0.630772982463435,0.487384960344436,-5.82464213445084,0.266496632410011,"PLEK","pleckstrin",TRUE
+"218644_at",0.385708334962145,0.0126770530942291,2.71219337263384,-2.87865448133006,2.30096642954789,"PLEK2","pleckstrin 2",TRUE
+"226247_at",0.137309434234578,0.000891538164668955,3.83528433559524,-0.555326837628317,1.77659749711315,"PLEKHA1","pleckstrin homology domain containing A1",TRUE
+"219024_at",0.142607803108174,0.000966267807692312,3.80222561126652,-0.626316491557697,1.7227252570128,"PLEKHA1","pleckstrin homology domain containing A1",TRUE
+"217677_at",0.478045735223536,0.0266098696179692,2.37520520496466,-3.51189083639829,1.26637563453645,"PLEKHA2","pleckstrin homology domain containing A2",TRUE
+"225136_at",0.51804700378812,0.0370189235262951,2.21918043393969,-3.78933612334109,1.85198079014802,"PLEKHA2","pleckstrin homology domain containing A2",TRUE
+"238013_at",0.55937703282623,0.053351719512873,2.04088971622358,-4.09211007713336,1.75756689096172,"PLEKHA2","pleckstrin homology domain containing A2",TRUE
+"223370_at",0.712975827977365,0.187464715711988,1.36014042979783,-5.07668410847798,0.478601573568259,"PLEKHA3","pleckstrin homology domain containing A3",TRUE
+"227659_at",0.806649582904638,0.347718706225711,0.959383188149168,-5.50105853600153,0.549871897323372,"PLEKHA3","pleckstrin homology domain containing A3",TRUE
+"227658_s_at",0.888603757551911,0.554794291134742,0.599693555801337,-5.76602165766386,0.215539229337828,"PLEKHA3","pleckstrin homology domain containing A3",TRUE
+"219011_at",0.895213601869362,0.573469066968448,0.571416010656182,-5.78188866052662,0.496194409371657,"PLEKHA4","pleckstrin homology domain containing A4",TRUE
+"220952_s_at",0.550815664569158,0.0491729539782727,2.08124707879759,-4.02499370456133,0.984824858697653,"PLEKHA5","pleckstrin homology domain containing A5",TRUE
+"214989_x_at",0.762729892034689,0.26232524254113,1.15019912877472,-5.3150772811463,0.386370883617182,"PLEKHA5","pleckstrin homology domain containing A5",TRUE
+"233040_at",0.822509813217163,0.387520023839465,-0.881481220099116,-5.56815558060932,-1.05183677976709,"PLEKHA5","pleckstrin homology domain containing A5",TRUE
+"205093_at",0.976422537443518,0.887715223185792,0.142830203116284,-5.92975204756883,0.151208955539072,"PLEKHA6","pleckstrin homology domain containing A6",TRUE
+"229245_at",0.993753494258002,0.97044702930855,0.0374684600551181,-5.93899972301641,0.030003154339334,"PLEKHA6","pleckstrin homology domain containing A6",TRUE
+"228450_at",0.608709711882903,0.0813962783078968,1.8257540370126,-4.43473025262302,0.995533426089215,"PLEKHA7","pleckstrin homology domain containing A7",TRUE
+"242417_at",0.679997635882293,0.147205340984048,1.50204076243998,-4.89676957692445,0.638460451937727,"PLEKHA7","pleckstrin homology domain containing A7",TRUE
+"231543_at",0.457531863501901,0.0227553804927079,-2.44773473742256,-3.37930287898769,-1.40672787248115,"PLEKHA8","pleckstrin homology domain containing A8",TRUE
+"227247_at",0.839519981963042,0.426540302337234,-0.810025191263949,-5.62505691701676,-0.303149329314136,"PLEKHA8","pleckstrin homology domain containing A8",TRUE
+"224208_at",0.889062160399946,0.55659275150123,-0.596949109328539,-5.76759407265475,-0.417604192567382,"PLEKHA8","pleckstrin homology domain containing A8",TRUE
+"233943_x_at",0.895457620469779,0.574199117748255,0.570320206277719,-5.78248860223777,0.236079136795381,"PLEKHA8","pleckstrin homology domain containing A8",TRUE
+"1560556_a_at",0.944801723928361,0.751822014593281,0.320193016918108,-5.88987102898516,0.299911743026875,"PLEKHA8","pleckstrin homology domain containing A8",TRUE
+"232212_at",0.984132887597385,0.922230658424021,0.0987424548398924,-5.93493569550087,0.039352836855941,"PLEKHA8","pleckstrin homology domain containing A8",TRUE
+"220157_x_at",0.821424121108148,0.38299047215393,-0.890071291711986,-5.56101424775197,-0.665740908194254,"PLEKHA8P1","pleckstrin homology domain containing A8 pseudogene 1",TRUE
+"209504_s_at",0.592605015502039,0.0697858486683487,1.90540725327829,-4.31095456511894,1.81781409232223,"PLEKHB1","pleckstrin homology domain containing B1",TRUE
+"229047_at",0.831875452294783,0.407744719329889,0.843899822668977,-5.59864143269289,0.545937264477252,"PLEKHB1","pleckstrin homology domain containing B1",TRUE
+"229046_s_at",0.863918945062466,0.490117932620933,0.701788337023204,-5.70260706969309,0.437078748365871,"PLEKHB1","pleckstrin homology domain containing B1",TRUE
+"224121_x_at",0.526253358601247,0.0396015285654472,2.18675542534133,-3.84557926710084,1.01984762458707,"PLEKHB2","pleckstrin homology domain containing B2",TRUE
+"201410_at",0.804658857755908,0.343699381848451,-0.967577113593675,-5.49369831788718,-0.34383523690669,"PLEKHB2","pleckstrin homology domain containing B2",TRUE
+"201411_s_at",0.968066640321622,0.849836570434877,-0.191553464055771,-5.92182759104797,-0.0858060116431805,"PLEKHB2","pleckstrin homology domain containing B2",TRUE
+"219566_at",0.703902004301726,0.175652426377102,1.39901341388746,-5.02885566573561,1.216271570615,"PLEKHF1","pleckstrin homology and FYVE domain containing 1",TRUE
+"218640_s_at",0.675622576285316,0.142113935577776,-1.52216073712779,-4.87009265753986,-0.949038765355667,"PLEKHF2","pleckstrin homology and FYVE domain containing 2",TRUE
+"222699_s_at",0.690015152288705,0.159668637879638,-1.45508298499773,-4.95791802182306,-0.991524424043332,"PLEKHF2","pleckstrin homology and FYVE domain containing 2",TRUE
+"226122_at",0.52248118659945,0.0382722844504947,2.20319617619411,-3.81712503126447,1.23523529057336,"PLEKHG1","pleckstrin homology and RhoGEF domain containing G1",TRUE
+"233986_s_at",0.657015752622694,0.125886110987304,1.59051878445758,-4.77736284649797,1.9348546458608,"PLEKHG2","pleckstrin homology and RhoGEF domain containing G2",TRUE
+"225979_at",0.819479221404744,0.376675580359723,0.902159000998073,-5.5508566070764,0.974651021394443,"PLEKHG2","pleckstrin homology and RhoGEF domain containing G2",TRUE
+"1558407_at",0.99186228645105,0.962481458987782,-0.0475746542112186,-5.93858114764806,-0.0280613050828951,"PLEKHG2","pleckstrin homology and RhoGEF domain containing G2",TRUE
+"217044_s_at",0.552420073963858,0.0496306305146242,2.07668040162371,-4.03263121633211,1.32990498466546,"PLEKHG3","pleckstrin homology and RhoGEF domain containing G3",TRUE
+"229952_at",0.6400637330139,0.11035904547091,1.66317875375072,-4.67533439051727,1.0828933952782,"PLEKHG3","pleckstrin homology and RhoGEF domain containing G3",TRUE
+"212821_at",0.695401065205265,0.164835808048655,1.43648233665892,-4.98170381598763,1.05088044503135,"PLEKHG3","pleckstrin homology and RhoGEF domain containing G3",TRUE
+"212823_s_at",0.913697616562839,0.638276484078666,0.476652999378148,-5.82962544757436,0.344632110829084,"PLEKHG3","pleckstrin homology and RhoGEF domain containing G3",TRUE
+"228171_s_at",0.970740500720217,0.86061327706924,-0.17764830543842,-5.92432397368424,-0.13464775410981,"PLEKHG4","pleckstrin homology and RhoGEF domain containing G4",TRUE
+"230441_at",0.644844656970274,0.115119490222291,1.6400359222743,-4.70821162243469,1.10365866946528,"PLEKHG4B","pleckstrin homology and RhoGEF domain containing G4B",TRUE
+"236255_at",0.822010986888098,0.385633258733568,0.885051365589949,-5.56519534493989,1.13271289267035,"PLEKHG4B","pleckstrin homology and RhoGEF domain containing G4B",TRUE
+"237646_x_at",0.61760967235709,0.0876958387528402,-1.78658961784897,-4.49419849799209,-0.988923736228947,"PLEKHG5","pleckstrin homology and RhoGEF domain containing G5",TRUE
+"227142_at",0.770986213019185,0.279516243951265,1.10854195192019,-5.35824219615545,0.422371484621054,"PLEKHG5","pleckstrin homology and RhoGEF domain containing G5",TRUE
+"220073_s_at",0.562462825747979,0.0550760046381125,2.02505545078664,-4.1182073291785,0.970846262638874,"PLEKHG6","pleckstrin homology and RhoGEF domain containing G6",TRUE
+"225726_s_at",0.852994610926182,0.459278415642434,-0.753166709616128,-5.66710558056297,-0.528242288649349,"PLEKHH1","pleckstrin homology, MyTH4 and FERM domain containing H1",TRUE
+"225727_at",0.955730092376044,0.797482683941104,-0.259713655953349,-5.90688379172737,-0.311013889167082,"PLEKHH1","pleckstrin homology, MyTH4 and FERM domain containing H1",TRUE
+"239568_at",0.519956259865057,0.0376080182524349,2.21160735787858,-3.8025172929437,2.43735687417786,"PLEKHH2","pleckstrin homology, MyTH4 and FERM domain containing H2",TRUE
+"243650_at",0.566552750683806,0.0570031959833551,2.00787206025387,-4.14637546681354,0.884654650660337,"PLEKHH2","pleckstrin homology, MyTH4 and FERM domain containing H2",TRUE
+"227148_at",0.809744885587232,0.353207238708183,0.948297372038913,-5.51092522321101,1.41029429819611,"PLEKHH2","pleckstrin homology, MyTH4 and FERM domain containing H2",TRUE
+"220259_at",0.71454754703986,0.189607381198796,-1.35329808801181,-5.084986568415,-1.47537654295438,"PLEKHH3","pleckstrin homology, MyTH4 and FERM domain containing H3",TRUE
+"227248_at",0.820611742812032,0.380859512248635,-0.894135553746979,-5.55761308198304,-0.46240160871444,"PLEKHH3","pleckstrin homology, MyTH4 and FERM domain containing H3",TRUE
+"216200_at",0.603702127972549,0.0776829805964548,1.85008785814794,-4.39731485496747,1.43971554333016,"PLEKHM1","pleckstrin homology and RUN domain containing M1",TRUE
+"212717_at",0.720018659171833,0.196004567804761,1.33322499318034,-5.10914070919632,0.40368095471015,"PLEKHM1","pleckstrin homology and RUN domain containing M1",TRUE
+"212146_at",0.973736211250369,0.873484047982059,0.16108778473116,-5.92705244369914,0.0575824303552022,"PLEKHM2","pleckstrin homology and RUN domain containing M2",TRUE
+"1560069_at",0.773446505563834,0.284877288139817,1.095934180641,-5.3710280452544,0.716332084836325,"PLEKHM3","pleckstrin homology domain containing M3",TRUE
+"235360_at",0.955527140391899,0.796333161043809,0.261223213410177,-5.90650202165496,0.122632282399206,"PLEKHM3","pleckstrin homology domain containing M3",TRUE
+"224125_at",0.979588787486838,0.902415262464132,0.124023086935347,-5.93219438497794,0.0593749564837918,"PLEKHN1","pleckstrin homology domain containing N1",TRUE
+"218223_s_at",0.831875452294783,0.407264764241186,0.844777638801593,-5.59794346773092,1.21602843184341,"PLEKHO1","pleckstrin homology domain containing O1",TRUE
+"204436_at",0.95743098854986,0.807971939857166,0.245967097647644,-5.91025913776758,0.0797459560575859,"PLEKHO2","pleckstrin homology domain containing O2",TRUE
+"1554190_s_at",0.526253358601247,0.0396651136862503,-2.18598158350979,-3.84691533667364,-3.58226636211304,"PLEKHS1","pleckstrin homology domain containing S1",TRUE
+"219857_at",0.737123149977386,0.223026699068243,-1.2536771629263,-5.20185138292192,-1.28042636089067,"PLEKHS1","pleckstrin homology domain containing S1",TRUE
+"230931_at",0.731548533938014,0.214792055532473,1.27709000117871,-5.17506837974188,0.997763570220752,"PLG","plasminogen",TRUE
+"240033_at",0.839519981963042,0.426977938991946,0.809247726364814,-5.62565128006773,0.251840728181314,"PLG","plasminogen",TRUE
+"209977_at",0.942373096422033,0.741113478071564,-0.334546443963746,-5.88531727010221,-0.210859667986879,"PLG","plasminogen",TRUE
+"209978_s_at",0.830592576740524,0.403143324143635,0.852342888574592,-5.59190017195297,0.601647504773517,"PLG///LPA","plasminogen///lipoprotein(a)",TRUE
+"230120_s_at",0.90466378569832,0.608891607949563,-0.519021342962663,-5.8093218024288,-0.205895829725399,"PLGLB1///PLGLB2","plasminogen-like B1///plasminogen-like B2",TRUE
+"214415_at",0.964958528401238,0.837373979671241,0.207682435428816,-5.91869728533816,0.109690525965621,"PLGLB1///PLGLB2","plasminogen-like B1///plasminogen-like B2",TRUE
+"205871_at",0.967558480465905,0.847717492268098,0.194292169666155,-5.92131382467237,0.154923163092824,"PLGLB1///PLGLB2","plasminogen-like B1///plasminogen-like B2",TRUE
+"1558603_at",0.897011777275924,0.582444959338372,0.557991641144734,-5.78916140813943,0.35779201984481,"PLGLB2","plasminogen-like B2",TRUE
+"218992_at",0.956960361976289,0.805124401479822,-0.249694001420163,-5.9093620515364,-0.155937169776854,"PLGRKT","plasminogen receptor with a C-terminal lysine",TRUE
+"205913_at",0.97689149311934,0.889823228587245,-0.140130157853627,-5.93012380789495,-0.0485132862118585,"PLIN1","perilipin 1",TRUE
+"209122_at",0.695812999227098,0.165833292253733,1.43294585225159,-4.9861978744718,1.68713021937432,"PLIN2","perilipin 2",TRUE
+"215895_x_at",0.913468969775679,0.63708543264437,0.478352693373844,-5.82884343801436,0.216260380155701,"PLIN2","perilipin 2",TRUE
+"202122_s_at",0.907576524801672,0.616815527011341,-0.507504472319518,-5.81500777916506,-0.20892683489104,"PLIN3","perilipin 3",TRUE
+"228409_at",0.843950128127185,0.440133822480656,-0.786103080887643,-5.64309932508229,-0.422846381011264,"PLIN4","perilipin 4",TRUE
+"1568667_s_at",0.756601922352523,0.252012065349578,1.17616445886294,-5.28746426367266,0.692267289956907,"PLIN5","perilipin 5",TRUE
+"1560456_at",0.857235095927283,0.472119711551671,0.731534145733729,-5.68234354738878,0.371001199456796,"PLIN5","perilipin 5",TRUE
+"238019_at",0.89316156038085,0.567411245058655,0.58053627590975,-5.77685213713019,0.34050002749234,"PLIN5","perilipin 5",TRUE
+"1560457_x_at",0.918359777258603,0.653207011939823,0.455464730663736,-5.83914514702135,0.236829159268146,"PLIN5","perilipin 5",TRUE
+"1568666_at",0.927552865877291,0.682377351132663,0.414661108651482,-5.85628121601375,0.2175952760735,"PLIN5","perilipin 5",TRUE
+"241368_at",0.986826902609552,0.938347395331834,-0.0782298812203384,-5.93670313567004,-0.0336410575194916,"PLIN5","perilipin 5",TRUE
+"202240_at",0.988953916818854,0.94666212961895,0.06766130601846,-5.93745392622599,0.0217028454212116,"PLK1","polo like kinase 1",TRUE
+"201939_at",0.729083413548563,0.210742076253414,1.28885917650454,-5.16144543971108,0.954625771602203,"PLK2","polo like kinase 2",TRUE
+"204958_at",0.552487641279619,0.0503201798989819,2.06987084911531,-4.04399960165646,0.924195064986745,"PLK3","polo like kinase 3",TRUE
+"229825_at",0.681321116294195,0.149186582611323,-1.49436500456975,-4.90687187444017,-0.721018460050262,"PLK3","polo like kinase 3",TRUE
+"215462_at",0.833355923558872,0.410792002877945,0.838341762060965,-5.6030450043453,0.265559327622009,"PLK3","polo like kinase 3",TRUE
+"204887_s_at",0.710842845257879,0.18449052906026,1.36974116237355,-5.06497576025389,0.483866397513601,"PLK4","polo like kinase 4",TRUE
+"204886_at",0.803489780415187,0.341646287670463,0.971787857801563,-5.48989376941696,0.42183782639632,"PLK4","polo like kinase 4",TRUE
+"211088_s_at",0.961539013416204,0.825623431804967,-0.222941605995434,-5.91550395552098,-0.0944362386232109,"PLK4","polo like kinase 4",TRUE
+"1558897_at",0.561084367279569,0.0546361286969614,2.02905242941587,-4.11163238547978,1.35342248937249,"PLK5","polo like kinase 5",TRUE
+"204519_s_at",0.892895911526563,0.566516030414237,-0.581888260812757,-5.77609895352374,-0.309238780649235,"PLLP","plasmolipin",TRUE
+"204939_s_at",0.346950498371304,0.00895238254791369,2.86531274277268,-2.57797540712715,2.19592012309861,"PLN","phospholamban",TRUE
+"204938_s_at",0.774230543658252,0.28872952193035,1.08698030224633,-5.38002934434807,0.462045507978548,"PLN","phospholamban",TRUE
+"204940_at",0.814709480171015,0.365579001898784,-0.923728031749797,-5.5324174052487,-0.525111202074011,"PLN","phospholamban",TRUE
+"200827_at",0.55074985379986,0.0489508898636556,2.08347656837826,-4.02126106621836,1.21747974381135,"PLOD1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",TRUE
+"202619_s_at",0.843155630388418,0.437563306881302,0.790591392414653,-5.63975294889945,0.635508246758983,"PLOD2","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2",TRUE
+"202620_s_at",0.897011777275924,0.582491764666464,0.55792191198196,-5.78919874658846,0.449855768792618,"PLOD2","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2",TRUE
+"202185_at",0.96351240321323,0.833766692618923,0.212361296317834,-5.91774207871349,0.12064547867646,"PLOD3","procollagen-lysine,2-oxoglutarate 5-dioxygenase 3",TRUE
+"210198_s_at",0.968035667633768,0.849345095415157,-0.192188514163626,-5.92170910627624,-0.170380881013783,"PLP1","proteolipid protein 1",TRUE
+"201136_at",0.860714927752408,0.480543336517792,0.71753165250323,-5.69198205485347,0.384049873131334,"PLP2","proteolipid protein 2",TRUE
+"209147_s_at",0.975265330414469,0.88046295622858,0.152127733097793,-5.9284177355358,0.11814089503407,"PLPP1","phospholipid phosphatase 1",TRUE
+"210946_at",0.979588787486838,0.902692535377609,-0.123668807750152,-5.93223709420693,-0.096462534731284,"PLPP1","phospholipid phosphatase 1",TRUE
+"209529_at",0.794911622610881,0.327109585681248,1.00211033487457,-5.46205242374139,0.664909595118464,"PLPP2","phospholipid phosphatase 2",TRUE
+"209355_s_at",0.63775882989625,0.109075131565795,-1.66956445605229,-4.66620092360857,-1.50372153137945,"PLPP3","phospholipid phosphatase 3",TRUE
+"212230_at",0.913140067375992,0.635380435293694,-0.480788307511493,-5.82771809410716,-0.385037796543605,"PLPP3","phospholipid phosphatase 3",TRUE
+"212226_s_at",0.970746197850005,0.860666153466465,-0.177580169733582,-5.9243357445353,-0.123294273246477,"PLPP3","phospholipid phosphatase 3",TRUE
+"236044_at",0.968980656821882,0.853550123772765,-0.186757651580553,-5.92270975241371,-0.238589650108636,"PLPP4","phospholipid phosphatase 4",TRUE
+"226150_at",0.620912785033482,0.0904687815340767,-1.77011544087858,-4.51893278176844,-1.15760922865478,"PLPP5","phospholipid phosphatase 5",TRUE
+"223568_s_at",0.673870607802125,0.140473447597311,-1.52876942726826,-4.86126851865848,-0.649170104052345,"PLPP5","phospholipid phosphatase 5",TRUE
+"226384_at",0.67622507827427,0.142783930725035,-1.51947966803594,-4.87366382711431,-1.09486645979378,"PLPP5","phospholipid phosphatase 5",TRUE
+"223569_at",0.881212599079924,0.537847823340883,-0.625787450491102,-5.75072381854037,-0.350316088509759,"PLPP5","phospholipid phosphatase 5",TRUE
+"227385_at",0.901704668741384,0.598577945102756,-0.534119052875151,-5.80167972891756,-0.264111799953842,"PLPP6","phospholipid phosphatase 6",TRUE
+"224506_s_at",0.695744345349551,0.165290203948458,1.43486919133573,-4.98375487594299,0.5197686513524,"PLPP7","phospholipid phosphatase 7 (inactive)",TRUE
+"1570250_at",0.656693876264681,0.124833354572849,1.59520096807649,-4.77089453241761,0.97479748955052,"PLPPR1","phospholipid phosphatase related 1",TRUE
+"219732_at",0.837345289209351,0.420124060982418,0.82148136208709,-5.6162367628547,0.398280914538718,"PLPPR1","phospholipid phosphatase related 1",TRUE
+"218509_at",0.529522722988603,0.0413158470282465,-2.16627520588864,-3.88084058218502,-0.701003560115433,"PLPPR2","phospholipid phosphatase related 2",TRUE
+"64899_at",0.564004192185035,0.05586577078006,-2.01794996028723,-4.12987447157033,-0.812967480812372,"PLPPR2","phospholipid phosphatase related 2",TRUE
+"220798_x_at",0.978400619481648,0.896120124769684,-0.132071024808903,-5.9311913270083,-0.103345751132722,"PLPPR3","phospholipid phosphatase related 3",TRUE
+"213496_at",0.957571530817866,0.809150183220431,-0.244426037888559,-5.91062615986428,-0.111179330726207,"PLPPR4","phospholipid phosphatase related 4",TRUE
+"231397_at",0.856852764868387,0.471045698283477,-0.733329976075607,-5.68109459953295,-0.758981805775441,"PLPPR5","phospholipid phosphatase related 5",TRUE
+"242825_at",0.972659629123427,0.867760386303228,0.168446311981974,-5.92587291563584,0.186522718289394,"PLPPR5","phospholipid phosphatase related 5",TRUE
+"227246_at",0.828607509614823,0.398744078747073,-0.86047292711656,-5.58534974799246,-0.425566227109028,"PLRG1","pleiotropic regulator 1",TRUE
+"225194_at",0.875853648693835,0.523814146477178,-0.647731759434223,-5.73737339549352,-0.220909198160905,"PLRG1","pleiotropic regulator 1",TRUE
+"205190_at",0.796077960192644,0.328259307042399,0.999678606312832,-5.46431384534926,0.342448491323195,"PLS1","plastin 1",TRUE
+"201215_at",0.743553048228796,0.234246867049924,1.2228165580727,-5.23650324810376,2.29452569556249,"PLS3","plastin 3",TRUE
+"202430_s_at",0.266375678672809,0.00406323394628482,3.20452615731214,-1.88947731035382,1.86573194119408,"PLSCR1","phospholipid scramblase 1",TRUE
+"202446_s_at",0.308861881799719,0.00645976900352862,3.00670365950395,-2.29438113727124,1.87765654574766,"PLSCR1","phospholipid scramblase 1",TRUE
+"244315_at",0.51531387545335,0.0358478317226339,2.23456672169607,-3.76247185168745,2.13883694615902,"PLSCR1","phospholipid scramblase 1",TRUE
+"241510_at",0.740610299769501,0.230470546213191,-1.23307516133302,-5.22506694008817,-1.0423755204485,"PLSCR2","phospholipid scramblase 2",TRUE
+"207374_at",0.76711764189372,0.268891064557363,1.1340591588816,-5.33196823129314,0.839766196938269,"PLSCR2","phospholipid scramblase 2",TRUE
+"218901_at",0.671298718565642,0.137261309606459,1.54189542651076,-4.84365226259524,1.47379150662167,"PLSCR4","phospholipid scramblase 4",TRUE
+"202075_s_at",0.279325273101419,0.00450884981977478,3.16039755598969,-1.98053581458635,4.65574486419574,"PLTP","phospholipid transfer protein",TRUE
+"221529_s_at",0.899798994481376,0.591661255730551,-0.544314705523677,-5.79639838784773,-0.335483332277307,"PLVAP","plasmalemma vesicle associated protein",TRUE
+"240963_x_at",0.712975827977365,0.187267069895239,1.36077468895915,-5.07591273137262,0.605090479717359,"PLXDC1","plexin domain containing 1",TRUE
+"219700_at",0.863918945062466,0.490207139835728,-0.701642494248272,-5.7027044475137,-0.392483377217776,"PLXDC1","plexin domain containing 1",TRUE
+"214081_at",0.943464796017993,0.746443464944397,0.327393507798098,-5.88761130630091,0.121666463646717,"PLXDC1","plexin domain containing 1",TRUE
+"227276_at",0.906845308365483,0.615052521772277,-0.5100608163835,-5.8137564321932,-0.591193934908056,"PLXDC2","plexin domain containing 2",TRUE
+"226865_at",0.913318423661584,0.636641824647285,-0.478986110957259,-5.8285513134837,-0.357293478039071,"PLXDC2","plexin domain containing 2",TRUE
+"236297_at",0.918295771595924,0.65312789519983,0.455576442496896,-5.83909606776698,0.421801271118481,"PLXDC2","plexin domain containing 2",TRUE
+"227995_at",0.929271233120274,0.689096897588082,-0.405364852066626,-5.85996432028945,-0.352859183185113,"PLXDC2","plexin domain containing 2",TRUE
+"238455_at",0.962901358483638,0.83172590338498,0.215010460868294,-5.91719184768165,0.182946596214331,"PLXDC2","plexin domain containing 2",TRUE
+"214807_at",0.975475861996229,0.883200394995872,-0.148616721761505,-5.9289314738479,-0.108900278918711,"PLXDC2","plexin domain containing 2",TRUE
+"1558140_at",0.703902004301726,0.175682610895315,1.39891146823049,-5.02898255687237,1.03581439740291,"PLXNA1","plexin A1",TRUE
+"221538_s_at",0.794620886196317,0.326592250490323,1.00320646428902,-5.46103143244453,0.615553256161931,"PLXNA1","plexin A1",TRUE
+"221537_at",0.812087026810972,0.356263729768413,0.942174275216697,-5.51632989349109,0.328458969878252,"PLXNA1","plexin A1",TRUE
+"213030_s_at",0.786851686785014,0.31273631354333,1.03302597862421,-5.43286873943249,0.948421078270065,"PLXNA2","plexin A2",TRUE
+"207290_at",0.835596094904413,0.414963057500588,0.830776261811435,-5.60899534056855,0.532189574538411,"PLXNA2","plexin A2",TRUE
+"227032_at",0.858226066210126,0.473877876343154,0.728599546921852,-5.68437821651818,0.638348611353849,"PLXNA2","plexin A2",TRUE
+"1567519_at",0.813858337064325,0.364736549302005,-0.925383233723332,-5.53098580216256,-0.551323100215478,"PLXNA3","plexin A3",TRUE
+"203623_at",0.891420607788025,0.561005574081247,-0.59023464082459,-5.77141170033103,-0.327243372637135,"PLXNA3","plexin A3",TRUE
+"1553139_s_at",0.916349280948806,0.646753433878113,-0.464596625239028,-5.8350942392878,-0.258837703375198,"PLXNA3","plexin A3",TRUE
+"232317_at",0.534211007350826,0.0423558247254839,-2.15422276718555,-3.90149510111929,-1.55238568705848,"PLXNA4","plexin A4",TRUE
+"228104_at",0.615637099066718,0.0859663337403719,-1.79709339409624,-4.47834100012957,-0.896381454758822,"PLXNA4","plexin A4",TRUE
+"234859_at",0.837839105061376,0.422556687638658,-0.817125115862981,-5.61960433845608,-0.368483553609433,"PLXNA4","plexin A4",TRUE
+"1562240_at",0.954744039829521,0.794301639501151,0.263892534330025,-5.90582156551898,0.147435204652719,"PLXNA4","plexin A4",TRUE
+"215668_s_at",0.635368778245437,0.106379542812684,-1.68318076875643,-4.64663688169695,-1.13200601404674,"PLXNB1","plexin B1",TRUE
+"215807_s_at",0.643082025527735,0.113315199758294,-1.64871090913091,-4.69592900669849,-1.54554162294701,"PLXNB1","plexin B1",TRUE
+"208890_s_at",0.978314802155638,0.895583500237218,-0.132757471259585,-5.931102858288,-0.0711258288572498,"PLXNB2","plexin B2",TRUE
+"211472_at",0.992451894371035,0.964879248233868,0.0445320111613309,-5.93871763200516,0.0196161505305694,"PLXNB2","plexin B2",TRUE
+"205957_at",0.96386380924285,0.834802136678298,-0.211017773651733,-5.91801853245866,-0.135597712850425,"PLXNB3","plexin B3",TRUE
+"235328_at",0.674795173134954,0.141130001002253,1.5261169395499,-4.8648138610368,1.27068597878413,"PLXNC1","plexin C1",TRUE
+"213241_at",0.769123153940876,0.274464780183638,1.12058346135825,-5.34590950894014,0.950812261921664,"PLXNC1","plexin C1",TRUE
+"206471_s_at",0.882464151621958,0.540114867304567,0.622271625092249,-5.75282161241841,0.40441156252468,"PLXNC1","plexin C1",TRUE
+"206470_at",0.979976490833035,0.904328322478206,0.121579046165515,-5.93248653790397,0.0607427724602112,"PLXNC1","plexin C1",TRUE
+"1563657_at",0.870808709484996,0.510376179300247,0.669048620165065,-5.72398192766012,0.209653430828507,"PLXND1","plexin D1",TRUE
+"212235_at",0.947062793209778,0.759786011470593,0.309562785543096,-5.89311613202922,0.405935667624237,"PLXND1","plexin D1",TRUE
+"38671_at",0.971216837324271,0.862340309174079,-0.175423321689737,-5.92470602610929,-0.135842421482693,"PLXND1","plexin D1",TRUE
+"239929_at",0.825971419451151,0.393525606131433,0.870192166679846,-5.57744297134899,0.341398306845859,"PM20D1","peptidase M20 domain containing 1",TRUE
+"225431_x_at",0.433660982257499,0.0196217413203266,2.51565856123552,-3.25319899713233,2.75258845789767,"PM20D2","peptidase M20 domain containing 2",TRUE
+"225421_at",0.462049949204478,0.023282077916019,2.43718110017585,-3.39873080362836,3.63999712496055,"PM20D2","peptidase M20 domain containing 2",TRUE
+"229495_at",0.606900628956089,0.0806194676837393,1.83076368091467,-4.42705647009472,1.15511548371161,"PM20D2","peptidase M20 domain containing 2",TRUE
+"204285_s_at",0.767082054772618,0.268800731588437,1.13427923695472,-5.33173932826655,1.42412551943808,"PMAIP1","phorbol-12-myristate-13-acetate-induced protein 1",TRUE
+"204286_s_at",0.82064687791745,0.381541117432749,0.892833947581916,-5.55870388859937,1.21061214665337,"PMAIP1","phorbol-12-myristate-13-acetate-induced protein 1",TRUE
+"206942_s_at",0.565043084457947,0.0562804914176453,-2.01425446081702,-4.13593166726033,-1.46497552907787,"PMCH","pro-melanin concentrating hormone",TRUE
+"224421_x_at",0.80056683899707,0.336381399341192,0.982665524274832,-5.47999571812683,0.762727480120741,"PMCHL1","pro-melanin concentrating hormone like 1 (pseudogene)",TRUE
+"224418_x_at",0.863559206655094,0.48861996332279,0.704239616708854,-5.70096748630872,0.230968213597989,"PMCHL1","pro-melanin concentrating hormone like 1 (pseudogene)",TRUE
+"224419_x_at",0.868397087637799,0.503836960940864,-0.679535036526646,-5.71724188100866,-0.263821286053715,"PMCHL1","pro-melanin concentrating hormone like 1 (pseudogene)",TRUE
+"217123_x_at",0.8920930097751,0.564223345388762,0.585355761864523,-5.77415947697206,0.601372993925243,"PMCHL1","pro-melanin concentrating hormone like 1 (pseudogene)",TRUE
+"224422_x_at",0.812896635201594,0.361887758438418,-0.930999372527884,-5.5261107674053,-0.619607508955503,"PMCHL2","pro-melanin concentrating hormone like 2 (pseudogene)",TRUE
+"224423_x_at",0.955574463869973,0.796492072127238,-0.261014493957338,-5.90655493816834,-0.197096840808583,"PMCHL2","pro-melanin concentrating hormone like 2 (pseudogene)",TRUE
+"209848_s_at",0.826161156561654,0.394352335064279,-0.868646884097827,-5.57870560705292,-0.69289903460712,"PMEL","premelanosome protein",TRUE
+"217875_s_at",0.766550448794594,0.26740580230981,1.13768461401475,-5.32819240495147,1.24310379809033,"PMEPA1","prostate transmembrane protein, androgen induced 1",TRUE
+"222449_at",0.803489780415187,0.341565795196789,0.971953293822377,-5.48974398460132,0.860965172250156,"PMEPA1","prostate transmembrane protein, androgen induced 1",TRUE
+"222450_at",0.907964244160782,0.617825783762083,0.506041151631455,-5.81572132398565,0.604072301977594,"PMEPA1","prostate transmembrane protein, androgen induced 1",TRUE
+"202337_at",0.627938764248877,0.0993438250418869,-1.72015126708846,-4.59291428536599,-0.665129006402383,"PMF1","polyamine-modulated factor 1",TRUE
+"206956_at",0.966111788889917,0.842206750929073,0.201421455199425,-5.91994233283252,0.0769635216263191,"PMF1-BGLAP///PMF1///BGLAP","PMF1-BGLAP readthrough///polyamine-modulated factor 1///bone gamma-carboxyglutamate protein",TRUE
+"221022_s_at",0.91671872326659,0.647695169017299,-0.463261575042229,-5.83569138397612,-0.273353498203448,"PMFBP1","polyamine modulated factor 1 binding protein 1",TRUE
+"211013_x_at",0.364513221153898,0.0106530480888397,2.78909405169496,-2.72854067054804,2.25873906461172,"PML","promyelocytic leukemia",TRUE
+"206503_x_at",0.379294069303545,0.0116753894583972,2.74866988186001,-2.80768385690947,2.76632783072597,"PML","promyelocytic leukemia",TRUE
+"209640_at",0.422574093216884,0.0176606688882086,2.56351878966703,-3.16327259354187,1.09549777594948,"PML","promyelocytic leukemia",TRUE
+"239582_at",0.51470556386048,0.0349156509906884,2.24714491933935,-3.7404275197501,0.640237040481403,"PML","promyelocytic leukemia",TRUE
+"235508_at",0.581852599439475,0.0640989908862307,1.94875233213044,-4.2420522543723,0.875168785954834,"PML","promyelocytic leukemia",TRUE
+"210362_x_at",0.712948021516228,0.187101704952332,1.36130576253219,-5.07526661630986,1.28069601097457,"PML","promyelocytic leukemia",TRUE
+"211588_s_at",0.73759219552868,0.224250207977779,1.25025524901528,-5.20573029305084,1.20969368506956,"PML","promyelocytic leukemia",TRUE
+"211014_s_at",0.746535697909741,0.238392199993266,1.21169867200486,-5.24880416725282,0.343262389504867,"PML","promyelocytic leukemia",TRUE
+"211012_s_at",0.763650705722297,0.263571507041551,1.14711289244309,-5.31832336663096,1.07960624209406,"PML","promyelocytic leukemia",TRUE
+"211589_at",0.888750194607196,0.55537238807557,0.598810875445055,-5.7665281444056,0.364973832838621,"PML","promyelocytic leukemia",TRUE
+"203467_at",0.988413199531519,0.94473681562538,0.0701077594870005,-5.93728980128607,0.0240295085673683,"PMM1","phosphomannomutase 1",TRUE
+"203201_at",0.692289844352812,0.161764474859461,-1.4474807468123,-4.96766959512994,-0.499168590045693,"PMM2","phosphomannomutase 2",TRUE
+"235127_at",0.196311354133641,0.00213276532885931,3.47498033068834,-1.32376333312826,2.25542286062148,"PMP2","peripheral myelin protein 2",TRUE
+"206826_at",0.790165216824181,0.319265309542638,1.01886215963672,-5.44633859105467,0.559559422670635,"PMP2","peripheral myelin protein 2",TRUE
+"210139_s_at",0.739340500562926,0.226833764301582,-1.24307612402265,-5.21383858615462,-1.49217458255523,"PMP22","peripheral myelin protein 22",TRUE
+"1565637_at",0.775351898377291,0.292120694232251,-1.07916903983884,-5.38782819076424,-0.879063132533813,"PMP22","peripheral myelin protein 22",TRUE
+"1565638_at",0.783844746433788,0.306452359239581,-1.04685615941562,-5.41955450293714,-0.922202770477527,"PMP22","peripheral myelin protein 22",TRUE
+"1565639_a_at",0.843753336849204,0.439437514620904,-0.787317293389694,-5.64219580798588,-0.600905314212779,"PMP22","peripheral myelin protein 22",TRUE
+"212088_at",0.519956259865057,0.0375001706600643,-2.21298568419923,-3.80012031324443,-0.660674254496909,"PMPCA","peptidase, mitochondrial processing alpha subunit",TRUE
+"1570542_a_at",0.955892698633978,0.799826709873017,-0.256637378606708,-5.90765498362964,-0.0922665553846205,"PMPCB","peptidase, mitochondrial processing beta subunit",TRUE
+"201682_at",0.97653817371061,0.888430943515559,-0.141913349624053,-5.92987908010786,-0.0518987477902151,"PMPCB","peptidase, mitochondrial processing beta subunit",TRUE
+"1554743_x_at",0.636800438127861,0.107839693765448,1.67576930373788,-4.65730067789845,1.02970599486555,"PMS1","PMS1 homolog 1, mismatch repair system component",TRUE
+"1554742_at",0.663819586595936,0.131820993334627,1.56471605888655,-4.81274174679421,1.12054190772659,"PMS1","PMS1 homolog 1, mismatch repair system component",TRUE
+"213677_s_at",0.829030239823335,0.400130119780933,0.857905262218415,-5.58742478892472,0.298487330269118,"PMS1","PMS1 homolog 1, mismatch repair system component",TRUE
+"236609_at",0.951135659117732,0.776724376471303,-0.287072500190907,-5.89962382684294,-0.113646614132533,"PMS1","PMS1 homolog 1, mismatch repair system component",TRUE
+"228803_at",0.972819824894874,0.868469125590278,-0.167534625315977,-5.92602190494634,-0.10051175198883,"PMS1","PMS1 homolog 1, mismatch repair system component",TRUE
+"209805_at",0.773754791548713,0.285354662282737,1.09481987679267,-5.37215183253111,0.38630197062597,"PMS2CL///PMS2","PMS2 C-terminal like pseudogene///PMS1 homolog 2, mismatch repair system component",TRUE
+"221206_at",0.85334340854827,0.461419021705026,-0.74953585457844,-5.6696925382733,-0.20902369040631,"PMS2CL///PMS2","PMS2 C-terminal like pseudogene///PMS1 homolog 2, mismatch repair system component",TRUE
+"214756_x_at",0.896229101808264,0.580019411927169,0.56160898869415,-5.78721818798594,0.143506452905946,"PMS2P1","PMS1 homolog 2, mismatch repair system component pseudogene 1",TRUE
+"217485_x_at",0.898405288322584,0.587730413401411,0.550135068116523,-5.79333993298305,0.130225162238943,"PMS2P1","PMS1 homolog 2, mismatch repair system component pseudogene 1",TRUE
+"216843_x_at",0.964970817135779,0.837500293858985,-0.207518685117308,-5.91873033177032,-0.0537996365350448,"PMS2P1","PMS1 homolog 2, mismatch repair system component pseudogene 1",TRUE
+"214526_x_at",0.987977863996795,0.942641569289953,-0.0727706409918301,-5.93710453481876,-0.0184583138683934,"PMS2P1","PMS1 homolog 2, mismatch repair system component pseudogene 1",TRUE
+"214757_at",0.919372089675945,0.657090842363863,-0.449988006843387,-5.8415368096038,-0.20644900595767,"PMS2P2","PMS1 homolog 2, mismatch repair system component pseudogene 2",TRUE
+"214473_x_at",0.884683644631586,0.543948972685506,-0.616343435723968,-5.75633300668716,-0.191306280549313,"PMS2P3","PMS1 homolog 2, mismatch repair system component pseudogene 3",TRUE
+"216525_x_at",0.885694554133555,0.547400423093992,-0.61102587195629,-5.75945514395836,-0.208780315737867,"PMS2P3","PMS1 homolog 2, mismatch repair system component pseudogene 3",TRUE
+"217488_x_at",0.91202803207519,0.631355262661433,0.486550083600495,-5.8250336946271,0.221423040478967,"PMS2P3","PMS1 homolog 2, mismatch repair system component pseudogene 3",TRUE
+"216111_x_at",0.954429420677162,0.790653347064119,0.268691150598044,-5.90458103661947,0.069657145439793,"PMS2P3","PMS1 homolog 2, mismatch repair system component pseudogene 3",TRUE
+"215192_at",0.87275380741294,0.517043778251715,-0.65843336775856,-5.73070250942035,-0.393155868051649,"PMS2P4","PMS1 homolog 2, mismatch repair system component pseudogene 4",TRUE
+"242201_at",0.560295667354693,0.0542504551876746,-2.03258055232549,-4.10582157311632,-0.79893563950535,"PMS2P5","PMS1 homolog 2, mismatch repair system component pseudogene 5",TRUE
+"239699_s_at",0.990797621966014,0.953412793541397,-0.0590866288077866,-5.93798317453573,-0.0315119903476031,"PMS2P5///PMS2P1","PMS1 homolog 2, mismatch repair system component pseudogene 5///PMS1 homolog 2, mismatch repair system component pseudogene 1",TRUE
+"215412_x_at",0.929686252550028,0.68993177315441,-0.404212381863048,-5.86041519432297,-0.155630907364035,"PMS2P8","PMS1 homolog 2, mismatch repair system component pseudogene 8",TRUE
+"213893_x_at",0.964270089028129,0.835740179916652,0.209800974713158,-5.91826740288367,0.0572422526916974,"PMS2P9///PMS2P5","PMS1 homolog 2, mismatch repair system component pseudogene 9///PMS1 homolog 2, mismatch repair system component pseudogene 5",TRUE
+"215667_x_at",0.971533909239293,0.864474159752933,0.172675472281016,-5.92517123387411,0.048146466187811,"PMS2P9///PMS2P5","PMS1 homolog 2, mismatch repair system component pseudogene 9///PMS1 homolog 2, mismatch repair system component pseudogene 5",TRUE
+"215410_at",0.630522419457597,0.101448664361563,1.70886363766295,-4.60940945003052,0.727096464080459,"PMS2P9///PMS2P6///LOC441259///PMS2P5///PMS2P4///PMS2P1","PMS1 homolog 2, mismatch repair system component pseudogene 9///PMS1 homolog 2, mismatch repair system component pseudogene 6///PMS1 homolog 2, mismatch repair system component pseudogene///PMS1 homolog 2, mismatch repair system component pseudogene 5///PMS1 homolog 2, mismatch repair system component pseudogene 4///PMS1 homolog 2, mismatch repair system component pseudogene 1",TRUE
+"203515_s_at",0.411110107932987,0.0162298649555448,-2.60168654010493,-3.09094800519776,-0.985592764781151,"PMVK","phosphomevalonate kinase",TRUE
+"229411_at",0.7994347047598,0.334570371522572,-0.986434267227554,-5.47654297371447,-0.654859710913994,"PNCK","pregnancy up-regulated nonubiquitous CaM kinase",TRUE
+"226412_at",0.73862515837628,0.225376927612099,1.2471166277517,-5.20928007136128,0.517796075532098,"PNISR","PNN interacting serine and arginine rich protein",TRUE
+"225507_at",0.769258076576208,0.276614897385906,1.1154385171573,-5.3511933104054,0.414689167889973,"PNISR","PNN interacting serine and arginine rich protein",TRUE
+"230375_at",0.856874648266698,0.471414365827097,0.732713264670459,-5.68152383218442,0.47092826859491,"PNISR","PNN interacting serine and arginine rich protein",TRUE
+"212176_at",0.884141670778791,0.542920392404703,0.617931606766332,-5.75539547528239,0.226655985432096,"PNISR","PNN interacting serine and arginine rich protein",TRUE
+"212177_at",0.941106542715586,0.736137238451165,0.34124074272929,-5.88312589905042,0.128313533604045,"PNISR","PNN interacting serine and arginine rich protein",TRUE
+"212179_at",0.95168059103032,0.778455720054964,-0.284782361886473,-5.90025919344805,-0.168345218037587,"PNISR","PNN interacting serine and arginine rich protein",TRUE
+"225298_at",0.662855903464759,0.130851864553524,-1.56886273800044,-4.80708670071431,-0.573342201769702,"PNKD","paroxysmal nonkinesigenic dyskinesia",TRUE
+"1555713_at",0.819479221404744,0.376736668356367,-0.902041432711532,-5.55095601314015,-0.579760208726192,"PNKD","paroxysmal nonkinesigenic dyskinesia",TRUE
+"233177_s_at",0.935982562460896,0.714019559308501,-0.371192882892303,-5.87279581465747,-0.179293601319056,"PNKD","paroxysmal nonkinesigenic dyskinesia",TRUE
+"218961_s_at",0.915421702513799,0.643503961023798,-0.469209845728507,-5.83301787315197,-0.182720762662228,"PNKP","polynucleotide kinase 3'-phosphatase",TRUE
+"1564414_a_at",0.826140850652187,0.394299093928149,0.868746336738144,-5.57862440804757,0.466492733842061,"PNLDC1","PARN like, ribonuclease domain containing 1",TRUE
+"205912_at",0.971216837324271,0.862360134040061,-0.175397786043726,-5.92471038297494,-0.125540628423191,"PNLIP","pancreatic lipase",TRUE
+"210722_at",0.992342196993659,0.964237308039777,-0.045346549257285,-5.9386819778222,-0.0248757562009629,"PNLIPRP1","pancreatic lipase related protein 1",TRUE
+"206694_at",0.99753019043878,0.987641550965203,-0.0156653840233887,-5.93956395409052,-0.00960690472231196,"PNLIPRP1","pancreatic lipase related protein 1",TRUE
+"211766_s_at",0.899852720655724,0.59385491946558,0.541074829007444,-5.79808716550082,0.498602205639947,"PNLIPRP2","pancreatic lipase related protein 2 (gene/pseudogene)",TRUE
+"1558846_at",0.808257777979515,0.350488901894411,0.953773199598264,-5.50606470497968,1.03162257295746,"PNLIPRP3","pancreatic lipase related protein 3",TRUE
+"218224_at",0.79782885150643,0.331579532666162,-0.992689092506643,-5.47078606661793,-0.390530001661915,"PNMA1","paraneoplastic Ma antigen 1",TRUE
+"209597_s_at",0.323645710780045,0.00736732130124668,2.94998118903971,-2.40878623077067,2.21051774820447,"PNMA2","paraneoplastic Ma antigen 2",TRUE
+"209598_at",0.587626678796111,0.0666013707805599,1.9292787854627,-4.27314015667722,2.28862906906202,"PNMA2","paraneoplastic Ma antigen 2",TRUE
+"220923_s_at",0.867079124799259,0.498711243485364,0.687808500317502,-5.71185345883007,0.4558454530705,"PNMA3","paraneoplastic Ma antigen 3",TRUE
+"223621_at",0.991036342037614,0.957974608377319,0.0532948321085917,-5.93830015096933,0.0354567136915742,"PNMA3","paraneoplastic Ma antigen 3",TRUE
+"235758_at",0.943988850936011,0.748994388061075,-0.323976302051237,-5.88868992661783,-0.328785901561828,"PNMA6A","paraneoplastic Ma antigen family member 6A",TRUE
+"218824_at",0.890302070370912,0.55866913945365,0.593786286036187,-5.76939755049789,0.89804198452502,"PNMAL1","paraneoplastic Ma antigen family like 1",TRUE
+"232003_at",0.869644002139811,0.507079468094823,0.674325797942754,-5.72060260917686,0.197004582750732,"PNMAL2","paraneoplastic Ma antigen family-like 2",TRUE
+"206793_at",0.854040699678541,0.463270950802244,0.746402755115944,-5.67191533134235,0.509153064414047,"PNMT","phenylethanolamine N-methyltransferase",TRUE
+"210183_x_at",0.545992239117952,0.0472561592163755,-2.10079673204756,-3.99217578406718,-0.786604250585233,"PNN","pinin, desmosome associated protein",TRUE
+"1567213_at",0.840124373724453,0.429135683756315,0.80542171034018,-5.62856841896816,0.318801228355548,"PNN","pinin, desmosome associated protein",TRUE
+"1567214_a_at",0.854184492233394,0.464137191934935,-0.744939807679308,-5.67295020526456,-0.213049436003324,"PNN","pinin, desmosome associated protein",TRUE
+"212036_s_at",0.867099100798202,0.498885429637683,-0.687526555928674,-5.71203811186636,-0.190122085916704,"PNN","pinin, desmosome associated protein",TRUE
+"212037_at",0.869082033398093,0.505955781539886,-0.676128924547982,-5.7194421262157,-0.21829736228662,"PNN","pinin, desmosome associated protein",TRUE
+"242905_at",0.760999517733817,0.260069062439074,1.15581396258349,-5.3091519738513,0.54359313774405,"PNO1","partner of NOB1 homolog",TRUE
+"203622_s_at",0.813838373616733,0.364712717519107,0.925430094131756,-5.53094523772265,0.321859083777627,"PNO1","partner of NOB1 homolog",TRUE
+"211697_x_at",0.88050015760535,0.535933511567416,0.628762441264164,-5.74893983710389,0.185172722505293,"PNO1","partner of NOB1 homolog",TRUE
+"205901_at",0.961362864777978,0.824569137515798,-0.224313299527332,-5.91520586255042,-0.170768334926316,"PNOC","prepronociceptin",TRUE
+"201695_s_at",0.834265235157814,0.412323822864286,0.835557702745599,-5.60524055600982,0.380271407004791,"PNP","purine nucleoside phosphorylase",TRUE
+"1553364_at",0.94895689004559,0.769349773345975,-0.296845022647696,-5.89685585370191,-0.232815518135043,"PNPLA1","patatin like phospholipase domain containing 1",TRUE
+"212705_x_at",0.851861294910063,0.456980426061455,0.7570758112818,-5.66430714733381,0.322681227077686,"PNPLA2","patatin like phospholipase domain containing 2",TRUE
+"39854_r_at",0.975242094553739,0.87974852616769,0.153044374316836,-5.92828164048009,0.0463060860792606,"PNPLA2","patatin like phospholipase domain containing 2",TRUE
+"233030_at",0.897699110987203,0.585205857734655,-0.553883301284528,-5.79135360708167,-0.287271670939067,"PNPLA3","patatin like phospholipase domain containing 3",TRUE
+"220675_s_at",0.974884920935236,0.877353187603406,0.156118670355455,-5.92781923973319,0.141851075481607,"PNPLA3","patatin like phospholipase domain containing 3",TRUE
+"209740_s_at",0.649010621432137,0.119822210434238,-1.61795046156985,-4.73925668441431,-1.30872380705108,"PNPLA4","patatin like phospholipase domain containing 4",TRUE
+"209739_s_at",0.851733415458562,0.456206873691021,-0.758394351479911,-5.66336014443705,-0.802122771356402,"PNPLA4","patatin like phospholipase domain containing 4",TRUE
+"233597_at",0.900277982211162,0.595135118276351,0.539186777311355,-5.79906678776152,0.361087877145605,"PNPLA5","patatin like phospholipase domain containing 5",TRUE
+"203718_at",0.423421354964585,0.0178222989790279,2.55939090641649,-3.17106253161716,1.00904810253624,"PNPLA6","patatin like phospholipase domain containing 6",TRUE
+"228383_at",0.643082025527735,0.113548035191549,-1.64758493957942,-4.69752603004655,-1.21172025725015,"PNPLA7","patatin like phospholipase domain containing 7",TRUE
+"236135_at",0.731054546207485,0.213900664363942,-1.27966558303237,-5.17209621831408,-0.888483958912255,"PNPLA7","patatin like phospholipase domain containing 7",TRUE
+"223309_x_at",0.805746717966166,0.345441557928456,0.964017485146526,-5.49690279216941,0.329049165124429,"PNPLA8","patatin like phospholipase domain containing 8",TRUE
+"223310_x_at",0.8920930097751,0.563486598853015,0.586471569166212,-5.77353300182181,0.223954334406598,"PNPLA8","patatin like phospholipase domain containing 8",TRUE
+"223982_s_at",0.896115372949367,0.577354478665326,0.56559209700516,-5.78506439503874,0.207765418605252,"PNPLA8","patatin like phospholipase domain containing 8",TRUE
+"218511_s_at",0.758966211371161,0.256426208637059,-1.16495631077599,-5.29944991930523,-0.396263215052317,"PNPO","pyridoxamine 5'-phosphate oxidase",TRUE
+"222653_at",0.896139457361073,0.578574519211824,-0.563767435433729,-5.78605287961576,-0.185361432643509,"PNPO","pyridoxamine 5'-phosphate oxidase",TRUE
+"225291_at",0.756952614607938,0.252541221072421,1.17481318749143,-5.28891459438292,0.395195132145901,"PNPT1","polyribonucleotide nucleotidyltransferase 1",TRUE
+"209034_at",0.980009054680439,0.906004422509269,-0.119438358712455,-5.93273765888793,-0.0788271547940429,"PNRC1","proline rich nuclear receptor coactivator 1",TRUE
+"222406_s_at",0.978928101156583,0.897534280436732,-0.130262356864321,-5.93142223429072,-0.0460125120663175,"PNRC2","proline rich nuclear receptor coactivator 2",TRUE
+"217779_s_at",0.997039490727282,0.984876247191569,0.019171049270319,-5.93950447244593,0.0059943820490318,"PNRC2","proline rich nuclear receptor coactivator 2",TRUE
+"234749_s_at",0.518874125067442,0.0372963019938737,-2.21560106322361,-3.79556953926621,-0.583918264401285,"POC1A","POC1 centriolar protein A",TRUE
+"226355_at",0.886943633644753,0.550739812752977,-0.605897806721965,-5.76244129967994,-0.187600043434745,"POC1A","POC1 centriolar protein A",TRUE
+"226283_at",0.615005518451136,0.0856485484356495,-1.79904319537407,-4.47538996387619,-0.846720201025963,"POC1B","POC1 centriolar protein B",TRUE
+"231832_at",0.564144814478888,0.0559874414367489,-2.01686325251621,-4.13165643225653,-0.877713430046903,"POC1B-GALNT4///GALNT4","POC1B-GALNT4 readthrough///polypeptide N-acetylgalactosaminyltransferase 4",TRUE
+"220442_at",0.761748280722165,0.261032550241083,-1.15341179596845,-5.31169007185055,-0.86842919120195,"POC1B-GALNT4///GALNT4","POC1B-GALNT4 readthrough///polypeptide N-acetylgalactosaminyltransferase 4",TRUE
+"227267_at",0.878774484192636,0.531912010821799,-0.635030873494899,-5.7451542625599,-0.194176921768802,"POC5","POC5 centriolar protein",TRUE
+"226522_at",0.582787861733797,0.0644450921269783,1.94601946429909,-4.24642797375433,1.07948948022735,"PODN","podocan",TRUE
+"233148_at",0.912051899719319,0.631526900412585,0.486304055325701,-5.82514895759998,0.367584744753437,"PODN","podocan",TRUE
+"220411_x_at",0.886088669019308,0.548799645157766,-0.608875182452218,-5.76071048179906,-0.365028581185427,"PODNL1","podocan like 1",TRUE
+"201578_at",0.474859593446097,0.0260845275105215,2.38449506780648,-3.49503156453255,2.13718277177203,"PODXL","podocalyxin like",TRUE
+"219152_at",0.982884736081404,0.916813067531305,0.105647002581217,-5.93424869007438,0.0833586744139687,"PODXL2","podocalyxin like 2",TRUE
+"219756_s_at",0.672434875127089,0.138401080930132,-1.53720923013859,-4.84995526401621,-1.45343036991639,"POF1B","premature ovarian failure, 1B",TRUE
+"1555382_at",0.837368340567858,0.420796560554821,-0.820275499127807,-5.61717062885902,-1.02682636331511,"POF1B","premature ovarian failure, 1B",TRUE
+"1555383_a_at",0.849935057946582,0.452143899965223,-0.765341989105673,-5.65834447429236,-0.95191787814344,"POF1B","premature ovarian failure, 1B",TRUE
+"212349_at",0.858826390511142,0.474830665756768,0.727011894469276,-5.68547575775884,0.239121206824532,"POFUT1","protein O-fucosyltransferase 1",TRUE
+"210433_at",0.8920930097751,0.563527316010049,0.58640988316483,-5.77356766584946,0.536310829999138,"POFUT1","protein O-fucosyltransferase 1",TRUE
+"207448_at",0.766390367856479,0.266872724382615,1.13898943922927,-5.32683085958323,0.675195301031191,"POFUT2","protein O-fucosyltransferase 2",TRUE
+"207449_s_at",0.803988341675731,0.342648730750629,0.969729767665387,-5.49175520694253,0.275276970978236,"POFUT2","protein O-fucosyltransferase 2",TRUE
+"1555546_a_at",0.885312914741353,0.546845683706355,-0.611879344407905,-5.75895579653094,-0.428227120459366,"POFUT2","protein O-fucosyltransferase 2",TRUE
+"209578_s_at",0.979606049979413,0.90302925514426,0.123238593486814,-5.93228879357578,0.0388067312166189,"POFUT2","protein O-fucosyltransferase 2",TRUE
+"218229_s_at",0.528176582660474,0.040824403078613,-2.17206637971341,-3.87089062030911,-0.69907415601133,"POGK","pogo transposable element with KRAB domain",TRUE
+"222564_at",0.726696341943087,0.206950473065458,-1.30003705983791,-5.1484085906859,-0.908175193361004,"POGK","pogo transposable element with KRAB domain",TRUE
+"239392_s_at",0.856857560656867,0.471275111774531,-0.732946177057757,-5.6813617648808,-0.3524272531963,"POGK","pogo transposable element with KRAB domain",TRUE
+"218587_s_at",0.7580782491858,0.254719402860542,1.16927299752966,-5.29484567822821,0.829610989489025,"POGLUT1","protein O-glucosyltransferase 1",TRUE
+"222681_at",0.96649413975112,0.843691491578262,-0.199499599931676,-5.92031689536375,-0.0759567092670146,"POGLUT1","protein O-glucosyltransferase 1",TRUE
+"215281_x_at",0.960278309202107,0.819995284196055,0.230269264650325,-5.91389042641301,0.104693103211246,"POGZ","pogo transposable element with ZNF domain",TRUE
+"212153_at",0.986342822130003,0.935371723106634,0.0820143119633502,-5.93640785590682,0.0270666242167596,"POGZ","pogo transposable element with ZNF domain",TRUE
+"204835_at",0.760439386481756,0.259370373482045,-1.15756005379932,-5.30730416655251,-0.389767803988516,"POLA1","DNA polymerase alpha 1, catalytic subunit",TRUE
+"236546_at",0.657015752622694,0.125815508415664,-1.59083177070753,-4.77693092632801,-1.2446978518384,"POLA2","DNA polymerase alpha 2, accessory subunit",TRUE
+"204441_s_at",0.903925276836898,0.605914456973526,-0.523366781179838,-5.80714412015904,-0.208907036640859,"POLA2","DNA polymerase alpha 2, accessory subunit",TRUE
+"244575_at",0.998047179825832,0.991258257994701,-0.0110806639443508,-5.93962367877257,-0.00443038837007137,"POLA2","DNA polymerase alpha 2, accessory subunit",TRUE
+"203616_at",0.730583674018334,0.213232532490223,-1.28160151091551,-5.16985884284815,-0.582207201136567,"POLB","DNA polymerase beta",TRUE
+"234907_x_at",0.893635011091274,0.569034267617202,0.57808791016164,-5.77821179181327,0.382916997848612,"POLB","DNA polymerase beta",TRUE
+"234352_x_at",0.966089564318167,0.842062633114037,-0.201608043187455,-5.9199057770178,-0.248968878431733,"POLB","DNA polymerase beta",TRUE
+"203422_at",0.831487912516861,0.406110062643861,0.846892241269758,-5.59625933502615,0.304984327844457,"POLD1","DAN polymerase delta 1, catalytic subunit",TRUE
+"201115_at",0.766550448794594,0.2677223895068,-1.13691060178656,-5.32899941289165,-0.34089032331867,"POLD2","DAN polymerase delta 2, accessory subunit",TRUE
+"239816_at",0.826140850652187,0.394071230710757,-0.869172075677108,-5.57827671198642,-0.467774090419832,"POLD3","DNA polymerase delta 3, accessory subunit",TRUE
+"212836_at",0.970558087080474,0.859949080393717,0.178504252393689,-5.92417572023034,0.0797653807990439,"POLD3","DNA polymerase delta 3, accessory subunit",TRUE
+"202996_at",0.9550451679854,0.794791858284611,0.263248231987815,-5.90598643851589,0.205885839078476,"POLD4","DNA polymerase delta 4, accessory subunit",TRUE
+"222425_s_at",0.736729371800085,0.22219784802896,-1.25600346099575,-5.19920921471255,-0.394418276504993,"POLDIP2","DNA polymerase delta interacting protein 2",TRUE
+"217806_s_at",0.78515014907967,0.310473255019944,-1.03798388692976,-5.42811412345519,-0.257358084882949,"POLDIP2","DNA polymerase delta interacting protein 2",TRUE
+"243411_at",0.868397087637799,0.503656433136231,0.679825617101577,-5.71705368520914,0.174109376729941,"POLDIP3","DNA polymerase delta interacting protein 3",TRUE
+"215357_s_at",0.930827859648584,0.69339433705638,0.399438544689013,-5.86226937419159,0.153528951539757,"POLDIP3","DNA polymerase delta interacting protein 3",TRUE
+"210583_at",0.950214160603623,0.774082889511945,0.29056956009796,-5.89864387663627,0.180357301030644,"POLDIP3","DNA polymerase delta interacting protein 3",TRUE
+"212100_s_at",0.97825928502075,0.895257093466817,0.133175040513191,-5.93104881829881,0.0410681117538427,"POLDIP3","DNA polymerase delta interacting protein 3",TRUE
+"216026_s_at",0.988065316951061,0.943087538623885,-0.0722038070534405,-5.9371445497972,-0.0266265445369402,"POLE","DNA polymerase epsilon, catalytic subunit",TRUE
+"205909_at",0.926263798296325,0.679701785286231,-0.418372983903548,-5.8547876545058,-0.161575512075704,"POLE2","DNA polymerase epsilon 2, accessory subunit",TRUE
+"208828_at",0.69826535129815,0.169180084291661,-1.42120363389815,-5.00105446473986,-0.454278635375866,"POLE3","DNA polymerase epsilon 3, accessory subunit",TRUE
+"1553587_a_at",0.863648730667543,0.489059300012905,-0.703520237582422,-5.70144922124658,-0.41278534406178,"POLE4","DNA polymerase epsilon 4, accessory subunit",TRUE
+"225844_at",0.876222142797526,0.524803777049668,-0.646173879091448,-5.7383357554077,-0.349218022998571,"POLE4","DNA polymerase epsilon 4, accessory subunit",TRUE
+"1565329_at",0.90998880119877,0.625447343682131,0.495037310578738,-5.82102259859829,0.491716649838682,"POLE4","DNA polymerase epsilon 4, accessory subunit",TRUE
+"203366_at",0.87851847718547,0.531465517172137,-0.635728414214096,-5.74473077659786,-0.20458710092757,"POLG","DNA polymerase gamma, catalytic subunit",TRUE
+"217636_at",0.977567227646254,0.892049102650914,0.13728029714457,-5.93050851402866,0.0910009762855317,"POLG","DNA polymerase gamma, catalytic subunit",TRUE
+"217635_s_at",0.999872928029983,0.999614624327469,-0.000488475542847256,-5.93968336453178,-0.000172343862061552,"POLG","DNA polymerase gamma, catalytic subunit",TRUE
+"205811_at",0.929234395612144,0.689036923845255,-0.405447661882538,-5.85993187444377,-0.173300074109946,"POLG2","DNA polymerase gamma 2, accessory subunit",TRUE
+"1557700_at",0.353309890338186,0.00941513507494719,2.84329243794025,-2.62165019911759,0.675375126905699,"POLH","DNA polymerase eta",TRUE
+"219380_x_at",0.712975827977365,0.187380172718563,1.3604116695332,-5.0763542672413,0.557825303703606,"POLH","DNA polymerase eta",TRUE
+"222879_s_at",0.776722799962286,0.294138922235375,1.07455110515537,-5.39241515913979,0.470479557750526,"POLH","DNA polymerase eta",TRUE
+"1557701_s_at",0.816800680706682,0.368478871388697,0.918049903844107,-5.53731054470015,0.335339713837143,"POLH","DNA polymerase eta",TRUE
+"231115_at",0.836802432816621,0.418827947247298,0.823808855949544,-5.61443062987235,0.291660770145349,"POLH","DNA polymerase eta",TRUE
+"233852_at",0.896159990898752,0.579133564369365,0.562931987786186,-5.78650443774351,0.284178903481578,"POLH","DNA polymerase eta",TRUE
+"219317_at",0.536559328842429,0.0434272417149823,-2.14208245057768,-3.92222725999842,-1.06234642675622,"POLI","DNA polymerase iota",TRUE
+"238992_at",0.623667408398064,0.095305647743629,-1.7423903684035,-4.56017865739679,-0.98958733032317,"POLI","DNA polymerase iota",TRUE
+"1555317_at",0.909052380289506,0.622736341811616,-0.498944229779391,-5.81915340413894,-0.49770114625201,"POLK","DNA polymerase kappa",TRUE
+"223260_s_at",0.945664467195782,0.754734223955279,-0.316301539212202,-5.89107157518904,-0.0937994467531578,"POLK","DNA polymerase kappa",TRUE
+"223261_at",0.994098505325585,0.972869712861201,0.0343955603516233,-5.9391072749138,0.0151565293129625,"POLK","DNA polymerase kappa",TRUE
+"221049_s_at",0.805652838979402,0.34498297697642,0.964953272360574,-5.49606141651081,0.56033514233526,"POLL","polymerase (DNA) lambda",TRUE
+"222238_s_at",0.898736771120062,0.588464794895366,0.549046221431564,-5.79391449748909,0.454401443610558,"POLM","DNA polymerase mu",TRUE
+"242804_at",0.896159990898752,0.57874673444312,-0.563510030551441,-5.78619207576869,-0.317299956178738,"POLN","DNA polymerase nu",TRUE
+"233454_at",0.975265330414469,0.880548203674627,-0.152018366276135,-5.92843391891622,-0.096884101559672,"POLN","DNA polymerase nu",TRUE
+"207746_at",0.849202680405497,0.450050239916409,0.768936842733969,-5.65573229471185,0.364760837061615,"POLQ","DNA polymerase theta",TRUE
+"219510_at",0.860110818801326,0.47956979078479,-0.719142590901161,-5.69088219436623,-0.288794323913908,"POLQ","DNA polymerase theta",TRUE
+"222704_at",0.916349280948806,0.646682189846648,-0.46469765914474,-5.83504898007929,-0.152443999445605,"POLR1A","RNA polymerase I subunit A",TRUE
+"235280_at",0.985498770484702,0.930219635852236,0.0885696219850839,-5.93586339821563,0.0639965575464743,"POLR1A","RNA polymerase I subunit A",TRUE
+"223403_s_at",0.801455134542848,0.338095973479682,-0.979110337149885,-5.48324177993597,-0.303826425354432,"POLR1B","RNA polymerase I subunit B",TRUE
+"220113_x_at",0.859276375962637,0.476306731149135,0.724555982996992,-5.68716904313694,0.22503724451337,"POLR1B","RNA polymerase I subunit B",TRUE
+"1557331_at",0.945966513604392,0.75559670017615,-0.315150002735577,-5.8914240440522,-0.0871176654700605,"POLR1B","RNA polymerase I subunit B",TRUE
+"233341_s_at",0.968066640321622,0.849899191230931,0.191472555578654,-5.92184265852044,0.053918341537619,"POLR1B","RNA polymerase I subunit B",TRUE
+"207515_s_at",0.947062793209778,0.759830724776247,0.309503206650835,-5.89313401390718,0.123999646874893,"POLR1C","RNA polymerase I subunit C",TRUE
+"209317_at",0.996261754016157,0.981794267952261,-0.0230784664681888,-5.93942406665027,-0.00897761737289393,"POLR1C","RNA polymerase I subunit C",TRUE
+"224857_s_at",0.812302873476553,0.357067275238632,0.940570409097901,-5.51774026865636,0.382180813983251,"POLR1D","RNA polymerase I subunit D",TRUE
+"218258_at",0.812302873476553,0.358840229199566,0.937040189077419,-5.52083683042938,0.408670905750162,"POLR1D","RNA polymerase I subunit D",TRUE
+"224874_at",0.965255754814725,0.83819296587943,0.206620826812764,-5.91891106707373,0.0838828847235256,"POLR1D","RNA polymerase I subunit D",TRUE
+"231041_at",0.817845908536187,0.370451937376775,-0.9142034926255,-5.54060940021225,-0.765199064575663,"POLR1E","RNA polymerase I subunit E",TRUE
+"1568997_at",0.876309093376839,0.52502639712148,-0.645823651367191,-5.73855179751796,-0.277076116636478,"POLR1E","RNA polymerase I subunit E",TRUE
+"218997_at",0.947926063538122,0.762768530728598,-0.305591177363364,-5.89430069747932,-0.143907262070062,"POLR1E","RNA polymerase I subunit E",TRUE
+"202725_at",0.866413278951381,0.497409170791127,0.689917860788877,-5.71046968707878,0.223635989429654,"POLR2A","RNA polymerase II subunit A",TRUE
+"217415_at",0.868874412351732,0.5052741095697,-0.677223868912283,-5.71873597879218,-0.427874027518262,"POLR2A","RNA polymerase II subunit A",TRUE
+"217420_s_at",0.896118635245982,0.578222381230968,0.564293885248243,-5.78576800078208,0.40123831126087,"POLR2A","RNA polymerase II subunit A",TRUE
+"1555837_s_at",0.599747222491044,0.0762078145818654,-1.86003642586517,-4.38191646281271,-0.441392073211684,"POLR2B","RNA polymerase II subunit B",TRUE
+"201803_at",0.723649742218726,0.200212654227873,-1.3202991112191,-5.12453389420936,-0.331180188217955,"POLR2B","RNA polymerase II subunit B",TRUE
+"1555836_at",0.899808883319249,0.593284930775062,-0.541916094909757,-5.79764959964854,-0.247532837640423,"POLR2B","RNA polymerase II subunit B",TRUE
+"208996_s_at",0.843816788557882,0.439831621364578,-0.786629910396419,-5.64270746319244,-0.231356431920513,"POLR2C","RNA polymerase II subunit C",TRUE
+"216282_x_at",0.891652303901657,0.561361785183408,0.589693833109638,-5.7717173692852,0.161397441613572,"POLR2C","RNA polymerase II subunit C",TRUE
+"214263_x_at",0.996224607226304,0.981167417076026,-0.0238732481202669,-5.93940589170945,-0.00585889138106666,"POLR2C","RNA polymerase II subunit C",TRUE
+"214144_at",0.655745626967443,0.124237126989502,-1.59786732765566,-4.76720441196848,-0.484387028729779,"POLR2D","RNA polymerase II subunit D",TRUE
+"203664_s_at",0.960116489822537,0.819404663439609,-0.231038973840953,-5.91371792575799,-0.0799150747139841,"POLR2D","RNA polymerase II subunit D",TRUE
+"217854_s_at",0.805746717966166,0.34535115761326,-0.964201890373553,-5.49673705059564,-0.371834860032395,"POLR2E","RNA polymerase II subunit E",TRUE
+"213887_s_at",0.835952408568777,0.416505999177142,-0.827989847458585,-5.6111741690637,-0.312166067033198,"POLR2E","RNA polymerase II subunit E",TRUE
+"209511_at",0.774230543658252,0.288702203540695,1.08704349510334,-5.3799660473734,0.48331881470976,"POLR2F","RNA polymerase II subunit F",TRUE
+"232643_at",0.847797601020174,0.447170631740312,-0.773897775917557,-5.6521084813785,-0.576846932997586,"POLR2F","RNA polymerase II subunit F",TRUE
+"202306_at",0.647741963817785,0.118844693962988,-1.62248059574059,-4.7329152174184,-0.520278127232251,"POLR2G","RNA polymerase II subunit G",TRUE
+"209302_at",0.981068842514938,0.9107656376686,0.113360495229597,-5.93342636400679,0.0330763795741387,"POLR2H","RNA polymerase II subunit H",TRUE
+"212955_s_at",0.599731655615302,0.0761908748039119,-1.86015163904424,-4.38173779262241,-0.733475325206708,"POLR2I","RNA polymerase II subunit I",TRUE
+"212782_x_at",0.972309558036541,0.866668963925693,-0.169850549124039,-5.9256418554459,-0.05990379600137,"POLR2J","RNA polymerase II subunit J",TRUE
+"228823_at",0.841967750949524,0.434625085881352,0.795741656604264,-5.63589094554378,0.345081625802974,"POLR2J2","RNA polymerase II subunit J2",TRUE
+"240014_at",0.109049446709661,0.000520565260013197,4.05560853158307,-0.0807008179068589,1.12360069531315,"POLR2J4","RNA polymerase II subunit J4, pseudogene",TRUE
+"222208_s_at",0.615821255316333,0.0868851424510323,1.7914907468112,-4.48680770292083,0.593417196145608,"POLR2J4","RNA polymerase II subunit J4, pseudogene",TRUE
+"224517_at",0.668518995965071,0.134673737224213,1.55265457362101,-4.82912365413718,0.507219773345819,"POLR2J4","RNA polymerase II subunit J4, pseudogene",TRUE
+"60815_at",0.813631136157676,0.3643144244461,0.926213560249616,-5.53026675483379,0.469097373552401,"POLR2J4","RNA polymerase II subunit J4, pseudogene",TRUE
+"202634_at",0.854810562588402,0.466744022512408,-0.740547042765905,-5.67604603541498,-0.239266234277052,"POLR2K","RNA polymerase II subunit K",TRUE
+"202635_s_at",0.942835367370539,0.743836045394311,-0.330890510566949,-5.88649590292448,-0.126243072869737,"POLR2K","RNA polymerase II subunit K",TRUE
+"202586_at",0.704481017254098,0.176480548747322,-1.39622154859522,-5.03232792367816,-0.608391186555804,"POLR2L","RNA polymerase II subunit L",TRUE
+"211730_s_at",0.835356968983422,0.414569291200662,-0.831488415993028,-5.60843737505426,-0.238948689680107,"POLR2L","RNA polymerase II subunit L",TRUE
+"227872_at",0.876590919968167,0.525307840279679,-0.645380998950098,-5.7388246919397,-0.211374003135774,"POLR3A","RNA polymerase III subunit A",TRUE
+"1564318_at",0.921603564091029,0.665632736928679,0.437991509141938,-5.84667644989068,0.351799627046486,"POLR3A","RNA polymerase III subunit A",TRUE
+"231763_at",0.944850801239076,0.752111205708774,0.319806356850727,-5.88999096656353,0.136826250130692,"POLR3A","RNA polymerase III subunit A",TRUE
+"1556804_s_at",0.474925593702279,0.0261458808787172,-2.38340126735059,-3.49701850508606,-1.58135870105371,"POLR3B","RNA polymerase III subunit B",TRUE
+"1556803_at",0.770075820151416,0.278710878858429,-1.11045108138208,-5.35629478173424,-0.789219305042279,"POLR3B","RNA polymerase III subunit B",TRUE
+"219459_at",0.992451894371035,0.964869202741331,0.0445447573374357,-5.93871707905231,0.0154991837898653,"POLR3B","RNA polymerase III subunit B",TRUE
+"210573_s_at",0.842048161961563,0.435206212587527,-0.79472132926815,-5.63665792743492,-0.293345861323472,"POLR3C","RNA polymerase III subunit C",TRUE
+"209382_at",0.865187396415238,0.494357413190808,-0.694874072823588,-5.70720241822848,-0.226410813044073,"POLR3C","RNA polymerase III subunit C",TRUE
+"208361_s_at",0.801587742916188,0.338940178826119,0.977364415566945,-5.48483196772539,0.260721663315286,"POLR3D","RNA polymerase III subunit D",TRUE
+"233459_at",0.54295328972902,0.0458968973360179,2.11509644764165,-3.96804642249479,0.788965601671837,"POLR3E","RNA polymerase III subunit E",TRUE
+"205218_at",0.8363408317442,0.417993327646339,-0.825310020744484,-5.61326318911645,-0.324877295829104,"POLR3F","RNA polymerase III subunit F",TRUE
+"206653_at",0.774230543658252,0.287785348826932,1.08916686536498,-5.37783727195101,0.621437479623927,"POLR3G","RNA polymerase III subunit G",TRUE
+"206654_s_at",0.849935057946582,0.452114202674359,0.765392909460014,-5.65830755405771,0.403573403195206,"POLR3G","RNA polymerase III subunit G",TRUE
+"231544_s_at",0.976330538523238,0.885555147618215,-0.145598071130076,-5.92936359923263,-0.146018984575222,"POLR3G","RNA polymerase III subunit G",TRUE
+"223269_at",0.919354071504066,0.65627209221153,-0.451141386965201,-5.84103549129043,-0.224692648969496,"POLR3GL","RNA polymerase III subunit G like",TRUE
+"232857_at",0.789503009592599,0.316667599457991,1.02447299543212,-5.4410227469899,0.6170902280052,"POLR3H","RNA polymerase III subunit H",TRUE
+"225678_at",0.886442673707182,0.549324136004063,-0.608069754006542,-5.76117950391654,-0.15760675173159,"POLR3H","RNA polymerase III subunit H",TRUE
+"225682_s_at",0.929972194057784,0.690986766170048,0.402756855413497,-5.8609828254718,0.16494821875299,"POLR3H","RNA polymerase III subunit H",TRUE
+"218866_s_at",0.529522722988603,0.0413029063425275,-2.16642689789548,-3.88058016691059,-0.995857369573503,"POLR3K","RNA polymerase III subunit K",TRUE
+"222766_at",0.678611044120554,0.146034745324904,-1.50661564671512,-4.89072870539507,-1.27345414466516,"POLR3K","RNA polymerase III subunit K",TRUE
+"228616_at",0.921729477898827,0.666242338973336,0.43713787784894,-5.84703697558769,0.229929149795217,"POLRMT","RNA polymerase mitochondrial",TRUE
+"203782_s_at",0.931370027472813,0.696305264002116,-0.395432549543468,-5.86380858079775,-0.123653439990569,"POLRMT","RNA polymerase mitochondrial",TRUE
+"203783_x_at",0.93674483928058,0.717386219186239,0.366612005014164,-5.87443125567858,0.215844777077138,"POLRMT","RNA polymerase mitochondrial",TRUE
+"205096_at",0.9882620262439,0.944119155502021,-0.0708926985699286,-5.9372359076234,-0.0205706916626651,"POM121","POM121 transmembrane nucleoporin",TRUE
+"212178_s_at",0.728385463227073,0.209849617133111,-1.29147610464858,-5.15840187043167,-0.490273449334602,"POM121C","POM121 transmembrane nucleoporin C",TRUE
+"213360_s_at",0.559434208511607,0.0539917606278738,-2.03495962645213,-4.10189947737649,-0.490973098334839,"POM121C///POM121","POM121 transmembrane nucleoporin C///POM121 transmembrane nucleoporin",TRUE
+"231190_at",0.709806520482984,0.182595861190547,-1.37592118939449,-5.05740279124536,-0.670480250449651,"POM121L10P","POM121 transmembrane nucleoporin like 10, pseudogene",TRUE
+"232736_s_at",0.980135507384952,0.906654475016028,0.118608276706919,-5.93283383602502,0.0878202085518449,"POM121L10P///POM121L8P///POM121L9P","POM121 transmembrane nucleoporin like 10, pseudogene///POM121 transmembrane nucleoporin like 8, pseudogene///POM121 transmembrane nucleoporin like 9, pseudogene",TRUE
+"1556291_at",0.643688366500038,0.11454648282403,-1.64277846157935,-4.70433392229397,-0.569956209180198,"POM121L12","POM121 transmembrane nucleoporin like 12",TRUE
+"1556292_s_at",0.993474831312851,0.969314653227443,-0.0389048758299059,-5.93894629406536,-0.0222339074289923,"POM121L12","POM121 transmembrane nucleoporin like 12",TRUE
+"216582_at",0.96635324070119,0.843267258383546,0.200048650608173,-5.9202102523988,0.0755505912648786,"POM121L2","POM121 transmembrane nucleoporin like 2",TRUE
+"1557633_at",0.823986074071652,0.391263401098276,-0.874431349961476,-5.57396847029668,-0.461062587525041,"POM121L8P","POM121 transmembrane nucleoporin like 8, pseudogene",TRUE
+"1553900_s_at",0.686747966354964,0.155258431107538,1.47134751066998,-4.93691595256161,0.574213404933323,"POM121L8P///POM121L9P///POM121L1P","POM121 transmembrane nucleoporin like 8, pseudogene///POM121 transmembrane nucleoporin like 9, pseudogene///POM121 transmembrane nucleoporin like 1, pseudogene",TRUE
+"222253_s_at",0.710842845257879,0.184417182097489,-1.3699794686793,-5.06468426689718,-1.20976909290625,"POM121L9P","POM121 transmembrane nucleoporin like 9, pseudogene",TRUE
+"206819_at",0.846529455216068,0.44481771768831,0.777965763505864,-5.64912052915252,0.636962116046383,"POM121L9P","POM121 transmembrane nucleoporin like 9, pseudogene",TRUE
+"205720_at",0.961212424803935,0.824257038628144,-0.224719441272008,-5.91511725170954,-0.0771281070354681,"POMC","proopiomelanocortin",TRUE
+"233639_at",0.631294544151106,0.102359924666848,1.70403855845884,-4.61643575200461,0.502234578816088,"POMGNT1","protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)",TRUE
+"233638_s_at",0.880685398344064,0.536190756204581,0.628362330984938,-5.74918024106552,0.205320996209123,"POMGNT1","protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)",TRUE
+"217944_at",0.964493033778966,0.836070367369988,-0.209372743554223,-5.91835464755696,-0.0752242040585838,"POMGNT1","protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)",TRUE
+"225689_at",0.907964244160782,0.617965147921053,0.5058393755593,-5.81581955639912,0.215120076604711,"POMGNT2","protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)",TRUE
+"1553246_a_at",0.973433731874338,0.871560129982358,0.163560200417884,-5.92666199122483,0.0471859690188285,"POMK","protein-O-mannose kinase",TRUE
+"217769_s_at",0.769258076576208,0.276343263233544,1.11608688885463,-5.35052862581063,0.256330257328655,"POMP","proteasome maturation protein",TRUE
+"222402_at",0.972848610759081,0.868562086613512,-0.167415055717863,-5.92604138538934,-0.072335444491527,"POMP","proteasome maturation protein",TRUE
+"218476_at",0.645740804644555,0.116841841888739,-1.63186085310291,-4.71974090331003,-0.774911754141387,"POMT1","protein O-mannosyltransferase 1",TRUE
+"220632_s_at",0.891249845423426,0.560547461933182,0.590930418240002,-5.77101804273837,0.271032967574908,"POMT2","protein O-mannosyltransferase 2",TRUE
+"225560_at",0.966051687342135,0.841285323379255,0.202614545278163,-5.91970800439397,0.0588521515381952,"POMT2","protein O-mannosyltransferase 2",TRUE
+"210910_s_at",0.977874971442423,0.893099637338978,-0.135935668379236,-5.93068728756611,-0.0871711952836023,"POMZP3","POM121 and ZP3 fusion",TRUE
+"204148_s_at",0.985498770484702,0.929612673087767,0.0893421533508883,-5.93579648060086,0.0689613877852544,"POMZP3///ZP3","POM121 and ZP3 fusion///zona pellucida glycoprotein 3 (sperm receptor)",TRUE
+"206345_s_at",0.942684843065067,0.743267124823686,0.331654090007916,-5.88625079194853,0.143970350639013,"PON1","paraoxonase 1",TRUE
+"206344_at",0.956398858120188,0.802453042595032,-0.253193606741422,-5.90850746996369,-0.22322780738812,"PON1","paraoxonase 1",TRUE
+"242700_at",0.812302873476553,0.358776734613529,-0.937166413699233,-5.52072629576932,-0.557010493200726,"PON2","paraoxonase 2",TRUE
+"210830_s_at",0.972405051071295,0.866992252942359,-0.1694345652812,-5.92571050290705,-0.0801678372496202,"PON2","paraoxonase 2",TRUE
+"201876_at",0.975196332002567,0.879311137617395,-0.153605626845735,-5.92819790785912,-0.0706315451429393,"PON2","paraoxonase 2",TRUE
+"213695_at",0.621733119678766,0.0920069180905577,1.76116367561194,-4.53230249670726,2.34976525787415,"PON3","paraoxonase 3",TRUE
+"213449_at",0.875938621758472,0.524304344840962,-0.646959885932849,-5.73785048827592,-0.29852345657846,"POP1","POP1 homolog, ribonuclease P/MRP subunit",TRUE
+"202868_s_at",0.890130209343675,0.558433585929536,0.594144781282801,-5.76919359768327,0.292063281255658,"POP4","POP4 homolog, ribonuclease P/MRP subunit",TRUE
+"227583_at",0.950214160603623,0.773955988389518,-0.29073765709299,-5.89859647583245,-0.174951411595178,"POP4","POP4 homolog, ribonuclease P/MRP subunit",TRUE
+"204839_at",0.863580149876938,0.488896138621689,0.703787358009103,-5.70127039782695,0.22605190838777,"POP5","POP5 homolog, ribonuclease P/MRP subunit",TRUE
+"209482_at",0.961395512423249,0.824833814788998,-0.223968898898291,-5.91528087790486,-0.0813116126186575,"POP7","POP7 homolog, ribonuclease P/MRP subunit",TRUE
+"219647_at",0.955816406528307,0.798656163637833,-0.258173274126751,-5.90727109128991,-0.181579220650597,"POPDC2","popeye domain containing 2",TRUE
+"203880_at",0.64513208805899,0.116286211774853,-1.63448700712845,-4.71604207059535,-0.648332930178263,"POPDC2///COX17","popeye domain containing 2///COX17, cytochrome c oxidase copper chaperone",TRUE
+"219926_at",0.48326647989572,0.0276392187038668,2.35748306137915,-3.54395050968208,2.82024961270408,"POPDC3","popeye domain containing 3",TRUE
+"208928_at",0.599805419912392,0.0763192284040417,-1.85927921823528,-4.38309052934532,-0.637437850696282,"POR","cytochrome p450 oxidoreductase",TRUE
+"219483_s_at",0.478691006415319,0.0267660032375387,2.37247683869034,-3.51683528643995,0.938667762450711,"PORCN","porcupine homolog (Drosophila)",TRUE
+"1555777_at",0.717937808890208,0.193824243960129,-1.34000786109448,-5.10101268728117,-0.722069279615404,"POSTN","periostin",TRUE
+"210809_s_at",0.947778780715578,0.76201649620704,0.306592132658418,-5.89400358281577,0.367258585461009,"POSTN","periostin",TRUE
+"214981_at",0.954449231029359,0.791003755915602,-0.268229978097119,-5.90470122232553,-0.267983211042028,"POSTN","periostin",TRUE
+"1555778_a_at",0.955892698633978,0.799688727685831,0.256818394736734,-5.90760985752488,0.372230594107056,"POSTN","periostin",TRUE
+"204354_at",0.307187194976884,0.0061746452177338,3.02611256010956,-2.25505011650234,0.801365870884027,"POT1","protection of telomeres 1",TRUE
+"204353_s_at",0.348854934125219,0.00916058194150884,2.85527439375543,-2.59790261809793,0.767181495523673,"POT1","protection of telomeres 1",TRUE
+"244705_at",0.704092960947689,0.175872493918264,1.39827047432304,-5.02978022312173,0.927556125617539,"POT1-AS1","POT1 antisense RNA 1",TRUE
+"210926_at",0.725583196024696,0.20457468535973,1.30712219878737,-5.14009571757778,0.344934613220534,"POTEKP","POTE ankyrin domain family member K, pseudogene",TRUE
+"242912_at",0.689168483917391,0.158240870919438,1.46030823563627,-4.95119139961488,1.24549215487696,"POTEM","POTE ankyrin domain family member M",TRUE
+"207846_at",0.971242929121865,0.863358241219485,0.174112316538671,-5.92492889125832,0.14748445960318,"POU1F1","POU class 1 homeobox 1",TRUE
+"1569675_at",0.896118635245982,0.577848049077667,0.564853692323372,-5.78546478840361,0.421347700951875,"POU2AF1","POU class 2 associating factor 1",TRUE
+"205267_at",0.920389295526597,0.661201305436806,-0.444206882729149,-5.84403061673615,-0.314602535808027,"POU2AF1","POU class 2 associating factor 1",TRUE
+"229753_at",0.158330890084666,0.00123653022526113,3.70072902852931,-0.843756049699843,1.47638466955556,"POU2F1","POU class 2 homeobox 1",TRUE
+"206789_s_at",0.410263142293979,0.0158766425350653,2.61159421457722,-3.07208762094453,0.722013153623893,"POU2F1","POU class 2 homeobox 1",TRUE
+"227254_at",0.536186589417525,0.0431008698763607,2.14575168459532,-3.91596902149419,0.524894922918124,"POU2F1","POU class 2 homeobox 1",TRUE
+"244006_at",0.817755229158552,0.370244657799817,0.91460693497418,-5.54026398934932,0.557004576501378,"POU2F1","POU class 2 homeobox 1",TRUE
+"242866_x_at",0.411939637089919,0.0164022421571971,2.59692472837201,-3.10000012840886,1.71860075218793,"POU2F2","POU class 2 homeobox 2",TRUE
+"229750_at",0.49018628652281,0.0293060487027962,2.33003512059492,-3.59333530323477,1.13180001524845,"POU2F2","POU class 2 homeobox 2",TRUE
+"211771_s_at",0.622434989367596,0.0929115096258807,1.75595889122693,-4.54005306637925,1.00041567320631,"POU2F2","POU class 2 homeobox 2",TRUE
+"228343_at",0.687545925823023,0.15655114236201,1.46654172404095,-4.94314126286537,0.990930353298856,"POU2F2","POU class 2 homeobox 2",TRUE
+"235661_at",0.914588178928864,0.640339788101506,0.473711918790539,-5.83097217122015,0.287760803658156,"POU2F2","POU class 2 homeobox 2",TRUE
+"211660_at",0.932091525948902,0.700422433507465,-0.389777738673849,-5.8659552896004,-0.164280510997579,"POU2F2","POU class 2 homeobox 2",TRUE
+"227749_at",0.962125056232529,0.827882444162492,0.220003978007852,-5.91613623152942,0.136917521421992,"POU2F2","POU class 2 homeobox 2",TRUE
+"207109_at",0.648795161766672,0.119613264391551,-1.618916179677,-4.73790598119669,-1.94288105301071,"POU2F3","POU class 2 homeobox 3",TRUE
+"215355_at",0.854350135157525,0.465183356653951,-0.743175161190339,-5.67419593741465,-0.734655386668961,"POU2F3","POU class 2 homeobox 3",TRUE
+"210475_at",0.877546037473893,0.528011165837587,-0.641135803596938,-5.7414327180372,-0.360138561263177,"POU3F1","POU class 3 homeobox 1",TRUE
+"208345_s_at",0.99874554378549,0.994708547623138,0.00670713125680768,-5.93966156994097,0.0051456007258075,"POU3F1","POU class 3 homeobox 1",TRUE
+"242455_at",0.602351341567358,0.0771912292836819,-1.8533858281741,-4.39221675820758,-1.5546935855792,"POU3F2","POU class 3 homeobox 2",TRUE
+"207084_at",0.833766866664969,0.411454952163028,-0.83713605509078,-5.60399668101923,-0.528620464670993,"POU3F2","POU class 3 homeobox 2",TRUE
+"237008_at",0.919485127002411,0.658055033382938,0.44863053731105,-5.84212522342197,0.337829804222926,"POU3F3","POU class 3 homeobox 3",TRUE
+"228780_at",0.932091525948902,0.700473958233387,-0.389707053272131,-5.8659819307642,-0.537268342042435,"POU3F3","POU class 3 homeobox 3",TRUE
+"208563_x_at",0.932411919177942,0.701733360718518,-0.38797993977713,-5.86663139624027,-0.336521467003581,"POU3F3","POU class 3 homeobox 3",TRUE
+"207694_at",0.7800665680871,0.301409744812668,1.05810024065711,-5.40861261484548,0.632347404617044,"POU3F4","POU class 3 homeobox 4",TRUE
+"206940_s_at",0.457032025390949,0.0226337592498352,2.45020389576428,-3.37475093901324,0.915553515778164,"POU4F1","POU class 4 homeobox 1",TRUE
+"211341_at",0.64513208805899,0.115859498915193,1.63651100221844,-4.71318823579443,1.45910348442279,"POU4F1","POU class 4 homeobox 1",TRUE
+"207725_at",0.965883239653478,0.840248122239,0.203957902370634,-5.9194425130446,0.0653380603019711,"POU4F2","POU class 4 homeobox 2",TRUE
+"208554_at",0.89390639630277,0.569892917346605,0.576794060476941,-5.77892806032282,0.40983829426063,"POU4F3","POU class 4 homeobox 3",TRUE
+"214532_x_at",0.937203701144735,0.721122407611022,-0.361537658778738,-5.87621946774503,-0.199098840018006,"POU5F1B","POU class 5 homeobox 1B",TRUE
+"210265_x_at",0.51531387545335,0.0359830884861732,-2.23276648011652,-3.76562083807668,-1.6053807038436,"POU5F1P3","POU class 5 homeobox 1 pseudogene 3",TRUE
+"210905_x_at",0.610033432202476,0.0824265949907288,-1.81917309764272,-4.44478798317378,-1.71771954536476,"POU5F1P4","POU class 5 homeobox 1 pseudogene 4",TRUE
+"208286_x_at",0.960614707352139,0.821156960338578,0.228755758713062,-5.91422795014855,0.18694442356144,"POU5F1P4///POU5F1P3///POU5F1B///POU5F1","POU class 5 homeobox 1 pseudogene 4///POU class 5 homeobox 1 pseudogene 3///POU class 5 homeobox 1B///POU class 5 homeobox 1",TRUE
+"1553325_at",0.470885186348082,0.0254855299795485,-2.39530057006876,-3.47537562160391,-0.875666155242394,"POU5F2","POU domain class 5, transcription factor 2",TRUE
+"205878_at",0.734730148360473,0.219686666033782,1.26309228106842,-5.19113197774344,1.16853301169193,"POU6F1","POU class 6 homeobox 1",TRUE
+"229809_at",0.926209999527899,0.679453047471201,0.418718366772625,-5.854648015907,0.309112841004246,"POU6F1","POU class 6 homeobox 1",TRUE
+"216330_s_at",0.930827859648584,0.69359384948319,-0.399163765553485,-5.86237543948245,-0.236168487192844,"POU6F1","POU class 6 homeobox 1",TRUE
+"216332_at",0.940227139261806,0.733024637186534,0.34543605461154,-5.88173068648201,0.109389064699985,"POU6F1","POU class 6 homeobox 1",TRUE
+"207450_s_at",0.913300726876965,0.636612784673214,0.47902758339434,-5.82853217370877,0.378773214242345,"POU6F2","POU class 6 homeobox 2",TRUE
+"233772_at",0.76524135343539,0.265345801749111,1.14273755561868,-5.32291216556726,1.57532393882447,"POU6F2-AS2","POU6F2 antisense RNA 2",TRUE
+"1569670_at",0.717937808890208,0.193789026276323,1.34011791130321,-5.10088052684921,0.562457834901462,"PP12613","uncharacterized LOC100192379",TRUE
+"1570115_at",0.398650588126476,0.0139992524774181,-2.66800753215008,-2.96404050624647,-2.62515924986208,"PP12708","uncharacterized LOC100130609",TRUE
+"1568706_s_at",0.848183177385184,0.44781301893897,0.772789407046384,-5.65292002008034,0.547108422702922,"PP12719","uncharacterized LOC100653022",TRUE
+"1569660_at",0.731054546207485,0.213630121785757,1.28044892394912,-5.17119124883812,0.742402816104238,"PP13439","uncharacterized LOC100128046",TRUE
+"214858_at",0.925091998149497,0.675442837268511,-0.424293901517654,-5.85237814882902,-0.4073925700905,"PP14571","uncharacterized LOC100130449",TRUE
+"1555322_at",0.980257327353916,0.907446830770932,-0.117596596487076,-5.93295014828041,-0.0417173453024855,"PP2672","uncharacterized LOC100130249",TRUE
+"1552747_a_at",0.951023815565189,0.776409720365671,-0.287488880246082,-5.89950776564449,-0.184907906299117,"PP2D1","protein phosphatase 2C like domain containing 1",TRUE
+"225458_at",0.774230543658252,0.287569357444982,-1.08966779550805,-5.37733452695954,-0.486251081875666,"PP7080","uncharacterized LOC25845",TRUE
+"217848_s_at",0.867852903118377,0.501032264560436,0.684056184412163,-5.71430502713938,0.196687581479313,"PPA1","pyrophosphatase (inorganic) 1",TRUE
+"1556284_at",0.399312926596283,0.0141679456515912,-2.66265594798278,-2.97433751668901,-0.822520372721917,"PPA2","pyrophosphatase (inorganic) 2",TRUE
+"220741_s_at",0.564004192185035,0.055884209961866,-2.01778513447327,-4.1301447905566,-0.622752941322169,"PPA2","pyrophosphatase (inorganic) 2",TRUE
+"1556285_s_at",0.591331966259927,0.0686593739016365,-1.91374010503922,-4.29779176140456,-0.542979688852659,"PPA2","pyrophosphatase (inorganic) 2",TRUE
+"1559496_at",0.884815577925557,0.544893356531408,0.614886672853317,-5.75719091990802,0.204648460793545,"PPA2","pyrophosphatase (inorganic) 2",TRUE
+"1554499_s_at",0.96351240321323,0.83382564909547,0.212284787642377,-5.91775786864694,0.103705793539471,"PPA2","pyrophosphatase (inorganic) 2",TRUE
+"214546_s_at",0.887747346625205,0.552912238057946,0.602570547846902,-5.7643658230561,0.363852582065131,"PPAN-P2RY11///P2RY11","PPAN-P2RY11 readthrough///purinergic receptor P2Y11",TRUE
+"221649_s_at",0.936156433021345,0.715331384705363,0.369406978405753,-5.87343579272681,0.210985580904143,"PPAN-P2RY11///PPAN","PPAN-P2RY11 readthrough///peter pan homolog (Drosophila)",TRUE
+"223438_s_at",0.390415895588582,0.0130303801644119,2.69997453357601,-2.90233146630151,1.35980537563819,"PPARA","peroxisome proliferator activated receptor alpha",TRUE
+"244689_at",0.507573068809926,0.0333642514914157,2.26877411955569,-3.70234799669569,1.5362664979615,"PPARA","peroxisome proliferator activated receptor alpha",TRUE
+"206870_at",0.597654932724127,0.073659721649433,1.8776232626156,-4.35455265417329,1.19805737425349,"PPARA","peroxisome proliferator activated receptor alpha",TRUE
+"226978_at",0.634202341398092,0.10528622311022,1.68878688598011,-4.63854703546008,1.19118690654268,"PPARA","peroxisome proliferator activated receptor alpha",TRUE
+"1558631_at",0.647518308302168,0.118391072539107,1.62459343597226,-4.72995289861595,1.55502858602214,"PPARA","peroxisome proliferator activated receptor alpha",TRUE
+"223437_at",0.660460734341314,0.128548528568333,1.57882131980122,-4.79345771796338,1.06404614070981,"PPARA","peroxisome proliferator activated receptor alpha",TRUE
+"237142_at",0.800887499728059,0.336812411930275,0.981770645763178,-5.48081379567747,0.854470415309745,"PPARA","peroxisome proliferator activated receptor alpha",TRUE
+"210771_at",0.84571977676742,0.443532739065368,0.780192919734993,-5.64747841618883,0.25153511193378,"PPARA","peroxisome proliferator activated receptor alpha",TRUE
+"1560981_a_at",0.947938416246738,0.763087304046477,-0.305166987404883,-5.89442631975993,-0.102155285751277,"PPARA","peroxisome proliferator activated receptor alpha",TRUE
+"208044_s_at",0.433123407417606,0.0194796608841315,2.51897241664245,-3.24700048739711,0.920573743652729,"PPARD","peroxisome proliferator activated receptor delta",TRUE
+"242218_at",0.512834526570271,0.0343334924627789,2.25515641439294,-3.72634812224183,1.15323326562459,"PPARD","peroxisome proliferator activated receptor delta",TRUE
+"37152_at",0.56861088242915,0.0584918405540722,1.99494886819214,-4.16745435344864,0.95427575304311,"PPARD","peroxisome proliferator activated receptor delta",TRUE
+"210636_at",0.626839388794963,0.0972868935215673,1.73138071130897,-4.57642378463421,1.61554221603549,"PPARD","peroxisome proliferator activated receptor delta",TRUE
+"208510_s_at",0.380731642340006,0.0119404359045452,2.73873806563394,-2.82705005621479,4.03042507879467,"PPARG","peroxisome proliferator activated receptor gamma",TRUE
+"1569141_a_at",0.581367983493308,0.063815320329047,1.95100196118245,-4.23844711765893,1.47593526968917,"PPARGC1A","PPARG coactivator 1 alpha",TRUE
+"219195_at",0.946941640414848,0.759224271779076,-0.310311381248277,-5.89289115954587,-0.351919584148166,"PPARGC1A","PPARG coactivator 1 alpha",TRUE
+"232181_at",0.632216562924782,0.103382901774258,-1.69866526023401,-4.62424281484459,-0.888289218591285,"PPARGC1B","PPARG coactivator 1 beta",TRUE
+"1553639_a_at",0.652357618974335,0.121427407193449,-1.61057809382024,-4.74954751118478,-1.22838435790126,"PPARGC1B","PPARG coactivator 1 beta",TRUE
+"1555282_a_at",0.75758205507897,0.253732832054981,-1.1717779484067,-5.29216702584746,-0.76429124526772,"PPARGC1B","PPARG coactivator 1 beta",TRUE
+"1563943_at",0.936992192746977,0.717825867048624,-0.366014385600427,-5.87464313649039,-0.225215485241606,"PPARGC1B","PPARG coactivator 1 beta",TRUE
+"235833_at",0.609190103562927,0.0815484658066221,-1.8247774416139,-4.4362244449934,-0.572409733842189,"PPAT","phosphoribosyl pyrophosphate amidotransferase",TRUE
+"209434_s_at",0.768852835478002,0.273428191911095,-1.1230743925717,-5.34334361778851,-0.416314633698857,"PPAT","phosphoribosyl pyrophosphate amidotransferase",TRUE
+"209433_s_at",0.972955406158631,0.868817591127258,0.167086430073626,-5.92609485408136,0.0613619758009474,"PPAT","phosphoribosyl pyrophosphate amidotransferase",TRUE
+"214146_s_at",0.402463840838386,0.0147907017175199,2.64340628324966,-3.01129474724135,1.31380760169651,"PPBP","pro-platelet basic protein",TRUE
+"208346_at",0.635174103121116,0.105956213765134,1.68534561645908,-4.64351533016249,0.9258326228184,"PPBPP2","pro-platelet basic protein pseudogene 2",TRUE
+"219066_at",0.974884920935236,0.877357882190003,-0.156112643593793,-5.92782015518571,-0.0573461966301618,"PPCDC","phosphopantothenoylcysteine decarboxylase",TRUE
+"218341_at",0.463552233135475,0.0236875308225873,-2.4292066330571,-3.41338064266342,-0.875851275875792,"PPCS","phosphopantothenoylcysteine synthetase",TRUE
+"233571_x_at",0.768852835478002,0.274091963169294,-1.12147855168858,-5.34498806282461,-0.500927012193864,"PPDPF","pancreatic progenitor cell differentiation and proliferation factor",TRUE
+"218010_x_at",0.79985507957204,0.335321211854861,-0.984870071185189,-5.47797747664257,-0.409975006076776,"PPDPF","pancreatic progenitor cell differentiation and proliferation factor",TRUE
+"227994_x_at",0.82064687791745,0.38143805155308,-0.893030666185813,-5.55853912359186,-0.364534515596816,"PPDPF","pancreatic progenitor cell differentiation and proliferation factor",TRUE
+"206547_s_at",0.866213023333941,0.497043300389357,0.690511136900545,-5.7100797599907,0.428412184363515,"PPEF1","protein phosphatase with EF-hand domain 1",TRUE
+"208411_x_at",0.713330901550199,0.187892471171376,-1.35876953707945,-5.07835034341037,-1.38524720695416,"PPEF2","protein phosphatase with EF-hand domain 2",TRUE
+"202066_at",0.91508975903772,0.642182883373784,-0.471088309779306,-5.8321666403914,-0.218030217743053,"PPFIA1","PTPRF interacting protein alpha 1",TRUE
+"210236_at",0.924153886772697,0.673402667563315,0.427135665814129,-5.85120987989168,0.228062244441587,"PPFIA1","PTPRF interacting protein alpha 1",TRUE
+"210235_s_at",0.973071267819624,0.870294585746018,0.165187112128656,-5.92640182783023,0.0954958347348569,"PPFIA1","PTPRF interacting protein alpha 1",TRUE
+"202065_s_at",0.980326403741224,0.908282014395275,-0.116530369673366,-5.933071654781,-0.060202642964283,"PPFIA1","PTPRF interacting protein alpha 1",TRUE
+"1558295_a_at",0.552420073963858,0.0499378328379059,2.0736362672752,-4.03771632094519,1.12994790154613,"PPFIA2","PTPRF interacting protein alpha 2",TRUE
+"232073_at",0.603702127972549,0.0778494319318472,1.84897565389278,-4.39903267552932,1.55858405965217,"PPFIA2","PTPRF interacting protein alpha 2",TRUE
+"206973_at",0.64151921255818,0.111912395964882,-1.65553626018425,-4.68623039852605,-1.23029370449014,"PPFIA2","PTPRF interacting protein alpha 2",TRUE
+"215280_s_at",0.327864702134751,0.00773366196061713,-2.92896358230997,-2.45096605531139,-1.57630582746431,"PPFIA3","PTPRF interacting protein alpha 3",TRUE
+"213368_x_at",0.642592458809121,0.112930595407222,-1.65057509132929,-4.69328310224603,-1.20768054161893,"PPFIA3","PTPRF interacting protein alpha 3",TRUE
+"214978_s_at",0.866365799176078,0.497302683883714,-0.690090508690435,-5.71035624832334,-0.659281846960416,"PPFIA4","PTPRF interacting protein alpha 4",TRUE
+"203736_s_at",0.348854934125219,0.00917632957183951,2.85452399259634,-2.59939108695745,1.54820677402014,"PPFIBP1","PPFIA binding protein 1",TRUE
+"214374_s_at",0.539609110035715,0.0443269940066371,2.1320943344443,-3.93922877815452,1.50904422378424,"PPFIBP1","PPFIA binding protein 1",TRUE
+"1569464_at",0.55679801038721,0.0520900196274455,2.05276792557947,-4.07244520913619,0.836900426277872,"PPFIBP1","PPFIA binding protein 1",TRUE
+"203735_x_at",0.605913415325856,0.0794581616632858,1.83833161766415,-4.41543532799257,0.805801611766105,"PPFIBP1","PPFIA binding protein 1",TRUE
+"214375_at",0.643082025527735,0.113570275050172,1.64747749148311,-4.69767838584474,0.995756894762756,"PPFIBP1","PPFIA binding protein 1",TRUE
+"212841_s_at",0.358427723880268,0.00982975568249725,-2.82442117976015,-2.65896727677882,-3.46860782189792,"PPFIBP2","PPFIA binding protein 2",TRUE
+"227025_at",0.638865555358241,0.109778543988855,-1.66605813533258,-4.6712193072319,-0.525315233771277,"PPHLN1","periphilin 1",TRUE
+"225073_at",0.76719388846109,0.269116327634769,-1.13351058700642,-5.3325386298401,-0.34917806477792,"PPHLN1","periphilin 1",TRUE
+"1555351_s_at",0.930083070178974,0.691451133242786,-0.402116469707359,-5.86123192670026,-0.123515104381536,"PPHLN1","periphilin 1",TRUE
+"234459_at",0.937504304897146,0.72301429392397,0.358971864755363,-5.87711429145754,0.227226803593919,"PPHLN1","periphilin 1",TRUE
+"1555350_at",0.973525457602222,0.872709707424924,-0.162082760732834,-5.9268960269037,-0.0434296618314072,"PPHLN1","periphilin 1",TRUE
+"235741_at",0.909441642299191,0.624017648178008,-0.497096717258489,-5.82003910110252,-0.173270702935967,"PPIA","peptidylprolyl isomerase A",TRUE
+"211765_x_at",0.996140682541913,0.98073896633706,0.0244164880887204,-5.93939311498291,0.00522931762715118,"PPIA","peptidylprolyl isomerase A",TRUE
+"217136_at",0.837368340567858,0.420693769436035,-0.820459736137023,-5.61702803191446,-0.255044672863103,"PPIAL4C///PPIAL4A///PPIAL4G","peptidylprolyl isomerase A like 4C///peptidylprolyl isomerase A like 4A///peptidylprolyl isomerase A like 4G",TRUE
+"200968_s_at",0.933922051839063,0.707303965661672,-0.380354854456006,-5.86946474782798,-0.159959295546628,"PPIB","peptidylprolyl isomerase B",TRUE
+"200967_at",0.978928101156583,0.897521161167257,-0.13027913401085,-5.93142010700836,-0.0431096765747707,"PPIB","peptidylprolyl isomerase B",TRUE
+"204518_s_at",0.597346378847428,0.0734412930072596,-1.87915545034565,-4.35216008505699,-0.834167219691025,"PPIC","peptidylprolyl isomerase C",TRUE
+"204517_at",0.598784188936573,0.07562148741851,-1.86403728376601,-4.37570742549588,-0.73699635332936,"PPIC","peptidylprolyl isomerase C",TRUE
+"228469_at",0.689377560557554,0.15841700068554,-1.45966159028884,-4.95202490692989,-0.806268347202075,"PPID","peptidylprolyl isomerase D",TRUE
+"204186_s_at",0.841550580403629,0.433314235731533,-0.798046310758303,-5.63415512689507,-0.276519727973676,"PPID","peptidylprolyl isomerase D",TRUE
+"204185_x_at",0.875938621758472,0.524145361247321,-0.647210180480137,-5.73769584179068,-0.226489642949161,"PPID","peptidylprolyl isomerase D",TRUE
+"229375_at",0.62952950109137,0.10039081335191,1.71451138386279,-4.60116627458321,0.46872877194752,"PPIE","peptidylprolyl isomerase E",TRUE
+"210502_s_at",0.906507435035949,0.614160023871873,-0.511356244357823,-5.81311997102841,-0.177586639773217,"PPIE","peptidylprolyl isomerase E",TRUE
+"202494_at",0.974805001962993,0.876531107663587,0.157174122056882,-5.9276583750756,0.0490577967010299,"PPIE","peptidylprolyl isomerase E",TRUE
+"237473_at",0.668587404382295,0.134880310867174,1.55178940130411,-4.83029488946751,0.777765064249694,"PPIEL","peptidylprolyl isomerase E like pseudogene",TRUE
+"222054_at",0.767030236469048,0.268765711390471,-1.13436457120771,-5.33165056163406,-0.933376066804035,"PPIEL","peptidylprolyl isomerase E like pseudogene",TRUE
+"201489_at",0.95743098854986,0.807906113376876,-0.246053211996386,-5.91023856093287,-0.12904368908548,"PPIF","peptidylprolyl isomerase F",TRUE
+"201490_s_at",0.998940972058269,0.996544529276286,-0.0043799300995055,-5.93967413703774,-0.00245734312378332,"PPIF","peptidylprolyl isomerase F",TRUE
+"208995_s_at",0.647192697955062,0.118110447923102,-1.62590390467583,-4.72811405547966,-0.421709365577831,"PPIG","peptidylprolyl isomerase G",TRUE
+"225902_at",0.726636642789909,0.206276294514941,-1.30204116895264,-5.14606108647639,-0.515349825792253,"PPIG","peptidylprolyl isomerase G",TRUE
+"208993_s_at",0.732320150624823,0.216715867162499,-1.27155927724878,-5.1814334381791,-0.3550213607383,"PPIG","peptidylprolyl isomerase G",TRUE
+"208994_s_at",0.893137418746145,0.566772672717261,-0.581500558651261,-5.77631511375383,-0.169015108259144,"PPIG","peptidylprolyl isomerase G",TRUE
+"236142_at",0.763650705722297,0.263559325958884,-1.14714300540329,-5.31829173105877,-0.752921849114797,"PPIH","peptidylprolyl isomerase H",TRUE
+"204228_at",0.964970817135779,0.837456268538595,-0.207575757697925,-5.91871881690618,-0.0658095631286404,"PPIH","peptidylprolyl isomerase H",TRUE
+"222500_at",0.768454993129265,0.271569956602536,1.12755707965901,-5.33871334138992,0.409178258505907,"PPIL1","peptidylprolyl isomerase like 1",TRUE
+"206063_x_at",0.473909998449918,0.0259426177477934,-2.38703414706846,-3.49041724859876,-0.708773546827005,"PPIL2","peptidylprolyl isomerase like 2",TRUE
+"206064_s_at",0.515810181619652,0.0361930709512166,-2.22998382751447,-3.77048525007193,-1.13708502341503,"PPIL2","peptidylprolyl isomerase like 2",TRUE
+"209299_x_at",0.675622576285316,0.142120811720185,-1.52213316876631,-4.87012940397169,-1.46751609445843,"PPIL2","peptidylprolyl isomerase like 2",TRUE
+"214986_x_at",0.864111333851332,0.491297163056934,-0.699861671247762,-5.70389192929436,-0.556549626684292,"PPIL2","peptidylprolyl isomerase like 2",TRUE
+"223999_at",0.871206814961775,0.511906806196472,0.666604966337633,-5.72553814473248,0.438397680155048,"PPIL2","peptidylprolyl isomerase like 2",TRUE
+"217407_x_at",0.895270475431143,0.57354620837543,-0.571300188224319,-5.78195212486577,-0.374004239787368,"PPIL2","peptidylprolyl isomerase like 2",TRUE
+"224364_s_at",0.51531387545335,0.0356499106685806,-2.23721219633197,-3.7578416104994,-0.890241602066157,"PPIL3","peptidylprolyl isomerase like 3",TRUE
+"226472_at",0.990324621813963,0.951581057734218,-0.0614128189283128,-5.93784667237977,-0.0198349131338471,"PPIL4","peptidylprolyl isomerase like 4",TRUE
+"214206_at",0.425751189365875,0.0182619316997002,2.54833779170891,-3.19189018633484,0.971966342387849,"PPIL6","peptidylprolyl isomerase like 6",TRUE
+"1560910_at",0.687949239097856,0.157261505381287,1.46391455541299,-4.94653746562892,0.70404966073817,"PPIL6","peptidylprolyl isomerase like 6",TRUE
+"1553684_at",0.968066640321622,0.850039428764415,0.191291368034328,-5.92187637781559,0.0782879638988154,"PPIL6","peptidylprolyl isomerase like 6",TRUE
+"204578_at",0.922806874030268,0.669636263871072,0.432391341185742,-5.84902904863099,0.206669601401897,"PPIP5K1","diphosphoinositol pentakisphosphate kinase 1",TRUE
+"1555255_a_at",0.948815741515659,0.767150420642734,-0.299765193388021,-5.89601091550574,-0.130844169875921,"PPIP5K1","diphosphoinositol pentakisphosphate kinase 1",TRUE
+"203253_s_at",0.378119110146051,0.0115724883181485,-2.75258344279829,-2.80004414785381,-0.809421959434957,"PPIP5K2","diphosphoinositol pentakisphosphate kinase 2",TRUE
+"203407_at",0.538560859739115,0.044050190484743,2.13514749557608,-3.93403708403584,1.27360860867253,"PPL","periplakin",TRUE
+"210407_at",0.380084968057051,0.0118167654429141,-2.74334598381861,-2.81806890959167,-0.991884552499761,"PPM1A","protein phosphatase, Mg2+/Mn2+ dependent 1A",TRUE
+"229027_at",0.573647621198441,0.060329381824728,-1.97939334050315,-4.19270543468578,-1.14726568912633,"PPM1A","protein phosphatase, Mg2+/Mn2+ dependent 1A",TRUE
+"203966_s_at",0.73223722457785,0.216307828252054,-1.27272917309726,-5.18008902493058,-0.646179803148009,"PPM1A","protein phosphatase, Mg2+/Mn2+ dependent 1A",TRUE
+"227728_at",0.954723352940649,0.794100235895261,0.264157275357793,-5.90575370387814,0.0942818511735819,"PPM1A","protein phosphatase, Mg2+/Mn2+ dependent 1A",TRUE
+"231370_at",0.96200396340887,0.827266169281704,-0.220805186652901,-5.91596461240852,-0.11294667429272,"PPM1A","protein phosphatase, Mg2+/Mn2+ dependent 1A",TRUE
+"235344_at",0.979588787486838,0.902861227360432,0.123453273324357,-5.93226301772705,0.0429937370925142,"PPM1A","protein phosphatase, Mg2+/Mn2+ dependent 1A",TRUE
+"209296_at",0.827011327018402,0.39542014666088,-0.866654078323123,-5.58033082974232,-0.293598290987699,"PPM1B","protein phosphatase, Mg2+/Mn2+ dependent 1B",TRUE
+"213225_at",0.8717332853209,0.51334607384503,-0.664310882908824,-5.72699414466919,-0.266417377882972,"PPM1B","protein phosphatase, Mg2+/Mn2+ dependent 1B",TRUE
+"230330_at",0.671298718565642,0.137135462963668,-1.54241481114351,-4.84295274747809,-1.14542955766865,"PPM1D","protein phosphatase, Mg2+/Mn2+ dependent 1D",TRUE
+"204566_at",0.722442821599878,0.198996762514618,-1.32401195439546,-5.12012527204409,-1.0254429561494,"PPM1D","protein phosphatase, Mg2+/Mn2+ dependent 1D",TRUE
+"205938_at",0.673322773608689,0.13905073408309,1.5345523669509,-4.85352202610569,1.76697682444744,"PPM1E","protein phosphatase, Mg2+/Mn2+ dependent 1E",TRUE
+"236302_at",0.798428326317339,0.332864494451355,0.989997066122545,-5.47326784896604,0.842309274217047,"PPM1E","protein phosphatase, Mg2+/Mn2+ dependent 1E",TRUE
+"37384_at",0.87825462101175,0.530574478223444,-0.637121401882257,-5.74388373793923,-0.267948097115932,"PPM1F","protein phosphatase, Mg2+/Mn2+ dependent 1F",TRUE
+"1555091_at",0.881791136741466,0.538654635135404,0.624535304960647,-5.75147224348585,0.481786585522267,"PPM1F","protein phosphatase, Mg2+/Mn2+ dependent 1F",TRUE
+"203063_at",0.904832003218088,0.609538936568789,0.518077845347691,-5.80979229153979,0.401383179353855,"PPM1F","protein phosphatase, Mg2+/Mn2+ dependent 1F",TRUE
+"1555470_a_at",0.94427954751284,0.750397842887707,0.322097919347953,-5.88927805504823,0.0870724364779409,"PPM1F","protein phosphatase, Mg2+/Mn2+ dependent 1F",TRUE
+"200913_at",0.8920930097751,0.564248581337539,0.585317555151029,-5.77418090787051,0.216681834514564,"PPM1G","protein phosphatase, Mg2+/Mn2+ dependent 1G",TRUE
+"212686_at",0.142607803108174,0.000968380757290936,-3.80132806913531,-0.628242806817106,-3.84912921663766,"PPM1H","protein phosphatase, Mg2+/Mn2+ dependent 1H",TRUE
+"233911_s_at",0.665616988562013,0.132855568288564,-1.56031711653269,-4.81872795299109,-0.732542170193104,"PPM1H","protein phosphatase, Mg2+/Mn2+ dependent 1H",TRUE
+"1558654_at",0.677013732819214,0.143750312527097,1.51563068586622,-4.87878187299323,1.01393183667166,"PPM1H","protein phosphatase, Mg2+/Mn2+ dependent 1H",TRUE
+"229484_at",0.899808883319249,0.593123380558899,-0.542154604369492,-5.79752542399851,-0.608807462325882,"PPM1J","protein phosphatase, Mg2+/Mn2+ dependent 1J",TRUE
+"226773_at",0.627092759817312,0.098382319693323,-1.72537548721773,-4.58525243311676,-0.94725838396058,"PPM1K","protein phosphatase, Mg2+/Mn2+ dependent 1K",TRUE
+"235061_at",0.654871394599269,0.12377578402906,-1.59993780631236,-4.76433565759531,-1.22702998328631,"PPM1K","protein phosphatase, Mg2+/Mn2+ dependent 1K",TRUE
+"244011_at",0.813442508625161,0.36355483096033,-0.927709313722583,-5.52896996291304,-0.535065279631948,"PPM1K","protein phosphatase, Mg2+/Mn2+ dependent 1K",TRUE
+"240050_s_at",0.909732972837956,0.62453425627857,-0.496352317469634,-5.82039505940399,-0.481603962805611,"PPM1K","protein phosphatase, Mg2+/Mn2+ dependent 1K",TRUE
+"242752_at",0.988608758532396,0.945086467141678,-0.0696634329827707,-5.93732004275767,-0.0575858721358724,"PPM1K","protein phosphatase, Mg2+/Mn2+ dependent 1K",TRUE
+"239488_at",0.592111379991983,0.0692453535003982,-1.9093906018257,-4.30466733961276,-1.64529364654391,"PPM1L","protein phosphatase, Mg2+/Mn2+ dependent 1L",TRUE
+"236339_at",0.612420348961838,0.0841178785411994,-1.80852323111049,-4.46100883745043,-1.44102441216295,"PPM1L","protein phosphatase, Mg2+/Mn2+ dependent 1L",TRUE
+"229506_at",0.62110896023334,0.0915700241682589,-1.7636931942981,-4.52852963629902,-1.11562121242705,"PPM1L","protein phosphatase, Mg2+/Mn2+ dependent 1L",TRUE
+"228457_at",0.757950630724418,0.25411559240435,-1.17080524287733,-5.2932077777512,-0.594284314437489,"PPM1L","protein phosphatase, Mg2+/Mn2+ dependent 1L",TRUE
+"228108_at",0.857316604145187,0.472544289125664,-0.730824884116091,-5.68283601725882,-0.624611946519125,"PPM1L","protein phosphatase, Mg2+/Mn2+ dependent 1L",TRUE
+"239855_at",0.906878681039516,0.615159982605962,0.509904900590612,-5.81383292957231,0.30675570906561,"PPM1L","protein phosphatase, Mg2+/Mn2+ dependent 1L",TRUE
+"226074_at",0.620912785033482,0.0908702665487609,1.76776631248818,-4.52244608728942,1.21266384584202,"PPM1M","protein phosphatase, Mg2+/Mn2+ dependent 1M",TRUE
+"229559_at",0.896118635245982,0.578027040958616,0.564585990406834,-5.78560982211302,0.242766605542656,"PPM1N","protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)",TRUE
+"238930_at",0.980009054680439,0.905255676275137,-0.120394573859034,-5.93262603715278,-0.0343252980387434,"PPM1N","protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)",TRUE
+"243443_at",0.864894115958506,0.493452652478826,-0.696346807167504,-5.70622724996991,-0.723309849990847,"PPME1","protein phosphatase methylesterase 1",TRUE
+"49077_at",0.932974802426538,0.704102405157651,-0.38473433840511,-5.8678441832152,-0.145936719695204,"PPME1","protein phosphatase methylesterase 1",TRUE
+"217841_s_at",0.990797621966014,0.953394942425146,-0.0591092969775719,-5.93798186977428,-0.0261823466318205,"PPME1","protein phosphatase methylesterase 1",TRUE
+"204788_s_at",0.684473834090662,0.153169407592122,-1.47918275313942,-4.92673105696672,-0.539961298799229,"PPOX","protoporphyrinogen oxidase",TRUE
+"238117_at",0.690381347688918,0.160035423453666,-1.45374674738312,-4.95963505513822,-0.61575023847239,"PPOX","protoporphyrinogen oxidase",TRUE
+"238118_s_at",0.956398858120188,0.802461313578166,0.253182766400148,-5.9085101353588,0.227277921930495,"PPOX","protoporphyrinogen oxidase",TRUE
+"200846_s_at",0.957504800422796,0.808236137801514,-0.245621492425544,-5.9103416473376,-0.0931958634173906,"PPP1CA","protein phosphatase 1 catalytic subunit alpha",TRUE
+"201408_at",0.593337376134677,0.0700233652159317,1.90366535315505,-4.31370106685536,0.567234550718553,"PPP1CB","protein phosphatase 1 catalytic subunit beta",TRUE
+"201409_s_at",0.594005743610726,0.070804866228135,1.89797030517545,-4.32266837694569,0.481569486365592,"PPP1CB","protein phosphatase 1 catalytic subunit beta",TRUE
+"228222_at",0.768852835478002,0.27288487060955,1.12438275539128,-5.34199386346173,0.351639725914357,"PPP1CB","protein phosphatase 1 catalytic subunit beta",TRUE
+"201407_s_at",0.901479103631253,0.598265556017558,0.534578293634587,-5.80144393126679,0.160612774679853,"PPP1CB","protein phosphatase 1 catalytic subunit beta",TRUE
+"200726_at",0.819018525257656,0.374270197375933,-0.90679837212872,-5.54692438251919,-0.261811063455987,"PPP1CC","protein phosphatase 1 catalytic subunit gamma",TRUE
+"201703_s_at",0.626725055602681,0.0972219665447949,-1.73173845614699,-4.57589712189021,-0.554031353335635,"PPP1R10","protein phosphatase 1 regulatory subunit 10",TRUE
+"201702_s_at",0.789595899448337,0.316856755713992,-1.02406334755087,-5.44141174999066,-0.517778620513206,"PPP1R10","protein phosphatase 1 regulatory subunit 10",TRUE
+"201500_s_at",0.836221360949212,0.417506551645022,0.826186417794438,-5.61258070404235,0.239343221318144,"PPP1R11","protein phosphatase 1 regulatory inhibitor subunit 11",TRUE
+"1566303_s_at",0.908257715102215,0.618927589378662,0.50444650088334,-5.8164966191492,0.151399413488793,"PPP1R11","protein phosphatase 1 regulatory inhibitor subunit 11",TRUE
+"1566302_at",0.914242258486146,0.639269826667916,-0.475236535351913,-5.83027506589872,-0.240018547640172,"PPP1R11","protein phosphatase 1 regulatory inhibitor subunit 11",TRUE
+"1566301_at",0.992093589969215,0.963299322181458,-0.0465367872510949,-5.93862871653774,-0.042159785687641,"PPP1R11","protein phosphatase 1 regulatory inhibitor subunit 11",TRUE
+"201602_s_at",0.820291269575398,0.378894116337762,0.897897296598154,-5.55445230164858,0.311493097148862,"PPP1R12A","protein phosphatase 1 regulatory subunit 12A",TRUE
+"201604_s_at",0.861659105448003,0.483299967602765,-0.712980497073143,-5.69507665097337,-0.256702486435026,"PPP1R12A","protein phosphatase 1 regulatory subunit 12A",TRUE
+"201603_at",0.92051722798026,0.661857169343638,-0.44328587492107,-5.84442499107688,-0.149817240939811,"PPP1R12A","protein phosphatase 1 regulatory subunit 12A",TRUE
+"1557553_at",0.755049574909504,0.248954678186451,1.18401362180134,-5.27901089988929,0.545315460889918,"PPP1R12B","protein phosphatase 1 regulatory subunit 12B",TRUE
+"233700_at",0.811989906563972,0.356132015718409,-0.942437407093833,-5.51609829539303,-0.593221938369917,"PPP1R12B","protein phosphatase 1 regulatory subunit 12B",TRUE
+"201958_s_at",0.821896104057596,0.384969993085648,0.886309107704022,-5.56414982863781,0.330563109276669,"PPP1R12B","protein phosphatase 1 regulatory subunit 12B",TRUE
+"201957_at",0.912823955119275,0.634460648238549,0.482103462135886,-5.82710812017783,0.187001747041306,"PPP1R12B","protein phosphatase 1 regulatory subunit 12B",TRUE
+"1555444_a_at",0.917887697142565,0.651323811462356,-0.458125387557068,-5.83797301406281,-0.385095753564589,"PPP1R12B","protein phosphatase 1 regulatory subunit 12B",TRUE
+"234265_at",0.851319596585235,0.45469402497181,0.760976932189602,-5.66150076572569,0.307122696738422,"PPP1R12C","protein phosphatase 1 regulatory subunit 12C",TRUE
+"234286_at",0.913299709879835,0.636267978907682,0.479520071019542,-5.82830476385518,0.131181565926542,"PPP1R12C","protein phosphatase 1 regulatory subunit 12C",TRUE
+"223152_at",0.990810941805126,0.956327522822732,0.0553857879132878,-5.93818948339614,0.0195579315588912,"PPP1R12C","protein phosphatase 1 regulatory subunit 12C",TRUE
+"216347_s_at",0.792436690618566,0.323786687092671,-1.00917200000912,-5.45545708832074,-0.327947251198887,"PPP1R13B","protein phosphatase 1 regulatory subunit 13B",TRUE
+"218849_s_at",0.899998627338565,0.594572134127753,0.540016828064749,-5.79863652309475,0.245402000951707,"PPP1R13L","protein phosphatase 1 regulatory subunit 13 like",TRUE
+"227006_at",0.411110107932987,0.0162649125014462,2.60071454272732,-3.09279641824703,3.78614440633796,"PPP1R14A","protein phosphatase 1 regulatory inhibitor subunit 14A",TRUE
+"212680_x_at",0.974536463688956,0.875374144575745,0.158659833409237,-5.92743010090745,0.0650723915736897,"PPP1R14B","protein phosphatase 1 regulatory inhibitor subunit 14B",TRUE
+"226907_at",0.517859245504688,0.0369524484700974,2.22004186951216,-3.78783503586766,2.83039250540377,"PPP1R14C","protein phosphatase 1 regulatory inhibitor subunit 14C",TRUE
+"220082_at",0.844472871821284,0.44120630376924,-0.784235203755143,-5.6444866808088,-0.283393779763155,"PPP1R14D","protein phosphatase 1 regulatory inhibitor subunit 14D",TRUE
+"37028_at",0.580152731323135,0.0627954981979024,1.95916316745644,-4.22534455887515,0.812886280144481,"PPP1R15A","protein phosphatase 1 regulatory subunit 15A",TRUE
+"202014_at",0.678455276397227,0.14597490017895,1.50685033608643,-4.89041841497917,0.853464635559385,"PPP1R15A","protein phosphatase 1 regulatory subunit 15A",TRUE
+"224692_at",0.485924764794363,0.0286000163348562,-2.34148148030663,-3.57278088302695,-0.811037796172668,"PPP1R15B","protein phosphatase 1 regulatory subunit 15B",TRUE
+"225203_at",0.984726013444734,0.925111141848903,-0.0950733933494928,-5.93528190016921,-0.0535287580969186,"PPP1R16A","protein phosphatase 1 regulatory subunit 16A",TRUE
+"233813_at",0.790887605610217,0.320967166228795,1.01520358776432,-5.44979059418543,0.346441732286658,"PPP1R16B","protein phosphatase 1 regulatory subunit 16B",TRUE
+"212750_at",0.93032716386748,0.691973418680295,0.401396416012099,-5.86151155157772,0.20462615480597,"PPP1R16B","protein phosphatase 1 regulatory subunit 16B",TRUE
+"41577_at",0.959623505183049,0.817749523439938,0.233196748716844,-5.91323129070859,0.134461191274477,"PPP1R16B","protein phosphatase 1 regulatory subunit 16B",TRUE
+"220231_at",0.735014654606339,0.220094374489529,1.26193715201445,-5.19245082532664,0.58427707769818,"PPP1R17","protein phosphatase 1 regulatory subunit 17",TRUE
+"231509_at",0.931370027472813,0.6960459505914,-0.395789146595641,-5.86367218659725,-0.304437061393229,"PPP1R17","protein phosphatase 1 regulatory subunit 17",TRUE
+"224927_at",0.552487641279619,0.0503226054608597,2.06984704366099,-4.0440393017571,1.15767078395036,"PPP1R18","protein phosphatase 1 regulatory subunit 18",TRUE
+"235129_at",0.660093442228076,0.128082859440611,-1.58085263776143,-4.79066943267921,-1.04770690596251,"PPP1R1A","protein phosphatase 1 regulatory inhibitor subunit 1A",TRUE
+"205478_at",0.827866702343255,0.39727143582534,-0.863207324793753,-5.5831336173888,-0.769548030509432,"PPP1R1A","protein phosphatase 1 regulatory inhibitor subunit 1A",TRUE
+"225165_at",0.902307786832759,0.601191959150079,-0.530280750748936,-5.80364279801174,-0.679724990038038,"PPP1R1B","protein phosphatase 1 regulatory inhibitor subunit 1B",TRUE
+"228646_at",0.747359606523751,0.239182412344812,1.20959589778209,-5.25111974782637,0.807474351854537,"PPP1R1C","protein phosphatase 1 regulatory inhibitor subunit 1C",TRUE
+"1555462_at",0.79782885150643,0.331536103598005,0.992780203245829,-5.47070196435097,0.877131150777558,"PPP1R1C","protein phosphatase 1 regulatory inhibitor subunit 1C",TRUE
+"213774_s_at",0.676468346171966,0.143290764499331,1.5174583563413,-4.87635288483647,0.701249741624386,"PPP1R2","protein phosphatase 1 regulatory inhibitor subunit 2",TRUE
+"236754_at",0.813442508625161,0.363546471891794,0.927725785597673,-5.5289556713704,0.500309625562488,"PPP1R2","protein phosphatase 1 regulatory inhibitor subunit 2",TRUE
+"202165_at",0.832605695407954,0.409159210766223,0.841316602703184,-5.60069146034709,0.319875287602953,"PPP1R2","protein phosphatase 1 regulatory inhibitor subunit 2",TRUE
+"202166_s_at",0.926789913499188,0.680921365018083,0.416680294116836,-5.85547037208056,0.158807209941672,"PPP1R2","protein phosphatase 1 regulatory inhibitor subunit 2",TRUE
+"1554145_a_at",0.615821255316333,0.0863285795351677,1.79487837549714,-4.4816906252894,0.600626990786827,"PPP1R21","protein phosphatase 1 regulatory subunit 21",TRUE
+"1553955_at",0.784440784255426,0.307406094987778,1.04474428950394,-5.42159789593537,0.29493171864039,"PPP1R21","protein phosphatase 1 regulatory subunit 21",TRUE
+"203955_at",0.936759298111847,0.717449676787221,-0.366525737825615,-5.8744618620396,-0.16883466124917,"PPP1R26","protein phosphatase 1 regulatory subunit 26",TRUE
+"1562447_a_at",0.544577979658206,0.0466112746623768,-2.10753429289561,-3.98081984645871,-1.20983433294911,"PPP1R26-AS1","PPP1R26 antisense RNA 1",TRUE
+"1559026_at",0.988139605576153,0.943399608779185,0.0718071754741015,-5.93717236355307,0.0461501679703877,"PPP1R26-AS1","PPP1R26 antisense RNA 1",TRUE
+"1557480_a_at",0.869060996512026,0.505621038848606,0.676666505493167,-5.71909556812361,0.202279736999616,"PPP1R27","protein phosphatase 1 regulatory subunit 27",TRUE
+"207377_at",0.842917136850585,0.436775224583702,0.791970687420558,-5.6387209773564,0.289893967841232,"PPP1R2P9","protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 9",TRUE
+"235402_at",0.597346378847428,0.0733356326529184,-1.87989804399722,-4.35100000289784,-1.2806226678797,"PPP1R32","protein phosphatase 1 regulatory subunit 32",TRUE
+"226434_at",0.901577893311515,0.598397076733088,-0.534384931882581,-5.80154323709,-0.195133286785952,"PPP1R35","protein phosphatase 1 regulatory subunit 35",TRUE
+"237654_at",0.900867933475689,0.596751035425474,0.536806431001579,-5.8002970935471,0.442938566297348,"PPP1R36","protein phosphatase 1 regulatory subunit 36",TRUE
+"213781_at",0.634292762720105,0.105463028335484,-1.68787696328739,-4.63986147028227,-1.56290367553259,"PPP1R37","protein phosphatase 1 regulatory subunit 37",TRUE
+"229262_at",0.722342723847071,0.198807742267046,-1.324590735889,-5.11943708805715,-0.640409027347483,"PPP1R37","protein phosphatase 1 regulatory subunit 37",TRUE
+"213751_at",0.997056683282451,0.985180600772714,0.0187851991247452,-5.93951160556813,0.010769509549462,"PPP1R37","protein phosphatase 1 regulatory subunit 37",TRUE
+"206895_at",0.797433634184053,0.330787285291163,0.994352463526801,-5.46924954155122,0.571455233429326,"PPP1R3A","protein phosphatase 1 regulatory subunit 3A",TRUE
+"211169_s_at",0.989054168712279,0.946905175331399,-0.067352503657478,-5.93747422868652,-0.0523586676093286,"PPP1R3A","protein phosphatase 1 regulatory subunit 3A",TRUE
+"222662_at",0.890362620543163,0.558839946029807,-0.593526380009891,-5.76954534016982,-0.350422372194204,"PPP1R3B","protein phosphatase 1 regulatory subunit 3B",TRUE
+"1552669_at",0.92391895959892,0.672849912408602,0.42790621673425,-5.85089178052322,0.296641827584409,"PPP1R3B","protein phosphatase 1 regulatory subunit 3B",TRUE
+"1552670_a_at",0.977063818674184,0.890680124267472,-0.139032906396095,-5.93027286123455,-0.0718952378030506,"PPP1R3B","protein phosphatase 1 regulatory subunit 3B",TRUE
+"240187_at",0.604122576293603,0.0784834505608315,1.84475808956,-4.40554009746465,0.789781701068251,"PPP1R3C","protein phosphatase 1 regulatory subunit 3C",TRUE
+"204284_at",0.907830501915195,0.617344604720206,-0.506737982402128,-5.81538178585245,-0.555467314001985,"PPP1R3C","protein phosphatase 1 regulatory subunit 3C",TRUE
+"204554_at",0.48580305784244,0.0282213045944745,-2.34772877233963,-3.56153828300599,-1.55061645113715,"PPP1R3D","protein phosphatase 1 regulatory subunit 3D",TRUE
+"204555_s_at",0.48580305784244,0.0283239545362258,-2.34602785677353,-3.56460093227664,-1.91779030474274,"PPP1R3D","protein phosphatase 1 regulatory subunit 3D",TRUE
+"227409_at",0.152865811663982,0.0011219456945289,-3.74078949107226,-0.758032660899286,-1.56731272406806,"PPP1R3E","protein phosphatase 1 regulatory subunit 3E",TRUE
+"229001_at",0.606103871227474,0.0796166072822262,-1.83729343236651,-4.41703157037844,-0.99237345851218,"PPP1R3E","protein phosphatase 1 regulatory subunit 3E",TRUE
+"227412_at",0.721868021715132,0.198018614727437,-1.32701170511593,-5.11655575599844,-0.396354758123154,"PPP1R3E","protein phosphatase 1 regulatory subunit 3E",TRUE
+"231197_at",0.712975827977365,0.187210149310602,1.36095744903068,-5.0756904054401,1.06689611041606,"PPP1R3F","protein phosphatase 1 regulatory subunit 3F",TRUE
+"232211_at",0.895213601869362,0.573090092080152,-0.571985129692044,-5.78157663340269,-0.504715755101,"PPP1R3F","protein phosphatase 1 regulatory subunit 3F",TRUE
+"232199_at",0.895457620469779,0.574554846164295,0.569786514390263,-5.7827803889788,0.284455504334617,"PPP1R3F","protein phosphatase 1 regulatory subunit 3F",TRUE
+"229365_at",0.920783004321385,0.663182696427468,0.441425668964215,-5.84521907940528,0.115861142260377,"PPP1R3F","protein phosphatase 1 regulatory subunit 3F",TRUE
+"213465_s_at",0.705559553212919,0.177155970324176,-1.39395220238844,-5.03514609825144,-0.500792973407279,"PPP1R7","protein phosphatase 1 regulatory subunit 7",TRUE
+"201214_s_at",0.798988977183044,0.3334491171717,-0.988774640970903,-5.47439278107862,-0.305101243147508,"PPP1R7","protein phosphatase 1 regulatory subunit 7",TRUE
+"201213_at",0.929088231432081,0.687737128565085,-0.407243087441041,-5.85922680207997,-0.155457971189377,"PPP1R7","protein phosphatase 1 regulatory subunit 7",TRUE
+"207830_s_at",0.964685626382167,0.836665939701856,-0.208600427062456,-5.91851154489429,-0.0559044039776193,"PPP1R8","protein phosphatase 1 regulatory subunit 8",TRUE
+"228494_at",0.915353407558177,0.643041745560954,0.469866883011094,-5.832720512934,0.501119540053718,"PPP1R9A","protein phosphatase 1 regulatory subunit 9A",TRUE
+"221088_s_at",0.91876780831279,0.654691196409023,0.453370169523194,-5.84006318282141,0.319316109833323,"PPP1R9A","protein phosphatase 1 regulatory subunit 9A",TRUE
+"233985_x_at",0.947926063538122,0.762873734266548,0.305451177251998,-5.89434217711136,0.261631819499559,"PPP1R9A","protein phosphatase 1 regulatory subunit 9A",TRUE
+"231966_at",0.98453870130544,0.924722708263558,-0.095568087668057,-5.9352359857154,-0.0788440128692072,"PPP1R9A","protein phosphatase 1 regulatory subunit 9A",TRUE
+"225124_at",0.509447491563159,0.0338979419169049,-2.2612318215977,-3.71565130263132,-1.33147970504522,"PPP1R9B","protein phosphatase 1 regulatory subunit 9B",TRUE
+"230455_at",0.794426378358553,0.326343236541986,1.00373450469649,-5.46053922716494,0.40317173470426,"PPP1R9B","protein phosphatase 1 regulatory subunit 9B",TRUE
+"208652_at",0.585036027492332,0.0654723470627612,-1.93798362036774,-4.25927012764524,-0.437854244760048,"PPP2CA","protein phosphatase 2 catalytic subunit alpha",TRUE
+"235502_at",0.606312240108248,0.079943562535422,-1.83515677855558,-4.42031471279067,-0.733887761229693,"PPP2CA","protein phosphatase 2 catalytic subunit alpha",TRUE
+"238719_at",0.961395512423249,0.824765685298857,-0.2240575470009,-5.91526158005031,-0.0797284677082128,"PPP2CA","protein phosphatase 2 catalytic subunit alpha",TRUE
+"201374_x_at",0.897949253801113,0.586075652875658,0.552591004390831,-5.79203992171175,0.50157409822393,"PPP2CB","protein phosphatase 2 catalytic subunit beta",TRUE
+"201375_s_at",0.986280972175967,0.932809710745931,-0.085273635533715,-5.9361423764619,-0.0284997304458514,"PPP2CB","protein phosphatase 2 catalytic subunit beta",TRUE
+"200695_at",0.790240875783718,0.319416854005317,-1.01853582432044,-5.44664695713426,-0.258827420534438,"PPP2R1A","protein phosphatase 2 scaffold subunit Aalpha",TRUE
+"202884_s_at",0.603702127972549,0.0779398161693668,1.84837258570841,-4.3999638182907,0.708267912988005,"PPP2R1B","protein phosphatase 2 scaffold subunit Abeta",TRUE
+"222351_at",0.700061364939874,0.171550072386339,1.41300067966857,-5.01137354565058,1.2887548025016,"PPP2R1B","protein phosphatase 2 scaffold subunit Abeta",TRUE
+"202886_s_at",0.750807729565285,0.243839043364653,1.19730960813939,-5.2645796284455,0.455806453282429,"PPP2R1B","protein phosphatase 2 scaffold subunit Abeta",TRUE
+"202883_s_at",0.855075448726859,0.467231622734073,0.739727006604912,-5.6766220382684,0.282440631833735,"PPP2R1B","protein phosphatase 2 scaffold subunit Abeta",TRUE
+"202885_s_at",0.977858230085336,0.892626590104572,0.136541111871038,-5.93060700892867,0.113937168250757,"PPP2R1B","protein phosphatase 2 scaffold subunit Abeta",TRUE
+"228013_at",0.861665593344139,0.483825033665571,0.712115331965334,-5.69566280688695,0.298940823147225,"PPP2R2A","protein phosphatase 2 regulatory subunit Balpha",TRUE
+"202313_at",0.896115372949367,0.577667595815714,0.565123622119962,-5.78531848018862,0.188102206590933,"PPP2R2A","protein phosphatase 2 regulatory subunit Balpha",TRUE
+"236492_at",0.909441642299191,0.624020055781079,0.497093247393746,-5.82004076153641,0.185613900436473,"PPP2R2A","protein phosphatase 2 regulatory subunit Balpha",TRUE
+"237636_at",0.994825233837873,0.975802510709058,0.0306760896912153,-5.93922515378864,0.0211437943399906,"PPP2R2A","protein phosphatase 2 regulatory subunit Balpha",TRUE
+"205643_s_at",0.955203530479627,0.795155707525791,0.262770092763713,-5.90610853260348,0.116461257910951,"PPP2R2B","protein phosphatase 2 regulatory subunit Bbeta",TRUE
+"213849_s_at",0.957174671135192,0.806025945489568,-0.248513657668134,-5.90964761782419,-0.155580287933052,"PPP2R2B","protein phosphatase 2 regulatory subunit Bbeta",TRUE
+"228025_s_at",0.549127954108835,0.0486106104603319,2.08691058060704,-4.0155067524467,0.896099750562309,"PPP2R2C","protein phosphatase 2 regulatory subunit Bgamma",TRUE
+"223574_x_at",0.584828007864693,0.064966495786887,-1.94192671640313,-4.25297318741842,-2.15672866829293,"PPP2R2C","protein phosphatase 2 regulatory subunit Bgamma",TRUE
+"228140_s_at",0.610404195568275,0.0827894853812126,-1.8168721737699,-4.44829834524442,-1.30164528844603,"PPP2R2C","protein phosphatase 2 regulatory subunit Bgamma",TRUE
+"228010_at",0.798428326317339,0.332771790742598,-0.990191042292056,-5.47308922694312,-0.932205521956957,"PPP2R2C","protein phosphatase 2 regulatory subunit Bgamma",TRUE
+"223573_s_at",0.809744885587232,0.353189798303522,-0.948332413021617,-5.51089420124254,-0.73375074526787,"PPP2R2C","protein phosphatase 2 regulatory subunit Bgamma",TRUE
+"228137_s_at",0.83149082353763,0.406184830797991,0.846755202468572,-5.59636859586723,0.615374749030697,"PPP2R2C","protein phosphatase 2 regulatory subunit Bgamma",TRUE
+"225066_at",0.932249295738588,0.701185332121638,-0.388731344720965,-5.86634918655212,-0.15861684757152,"PPP2R2D","protein phosphatase 2 regulatory subunit Bdelta",TRUE
+"221772_s_at",0.951810226174863,0.778909903675085,0.28418184750119,-5.90042496211408,0.200682717644376,"PPP2R2D","protein phosphatase 2 regulatory subunit Bdelta",TRUE
+"207749_s_at",0.498538741392062,0.0312572621031914,2.29967073304255,-3.64757965934801,1.12141580206281,"PPP2R3A","protein phosphatase 2 regulatory subunit B''alpha",TRUE
+"209632_at",0.514490373584066,0.0347059140649843,2.2500171165276,-3.73538336307897,1.29486488886637,"PPP2R3A","protein phosphatase 2 regulatory subunit B''alpha",TRUE
+"209633_at",0.527546822913581,0.0400421306357646,2.18141619015068,-3.85479173809339,1.29630690243764,"PPP2R3A","protein phosphatase 2 regulatory subunit B''alpha",TRUE
+"219264_s_at",0.84804025008315,0.44765047384819,-0.77306976948284,-5.65271484469493,-0.296310145146258,"PPP2R3B","protein phosphatase 2 regulatory subunit B''beta",TRUE
+"1566630_at",0.89390639630277,0.569875307926965,0.576820585103504,-5.7789133920298,0.432356615698557,"PPP2R3B","protein phosphatase 2 regulatory subunit B''beta",TRUE
+"218852_at",0.932018790587499,0.699414058823452,-0.391161508618842,-5.86543279097954,-0.13412573393116,"PPP2R3C","protein phosphatase 2 regulatory subunit B''gamma",TRUE
+"1569894_at",0.962808206628386,0.831027784393873,-0.215917055031229,-5.91700198851804,-0.0874943771792269,"PPP2R3C","protein phosphatase 2 regulatory subunit B''gamma",TRUE
+"239188_at",0.979588787486838,0.902524222059266,0.123883864343958,-5.9322111831552,0.102895289080009,"PPP2R3C","protein phosphatase 2 regulatory subunit B''gamma",TRUE
+"202187_s_at",0.516545992966588,0.0363916948284422,-2.22736519257836,-3.77505959584214,-1.05542182885406,"PPP2R5A","protein phosphatase 2 regulatory subunit B'alpha",TRUE
+"202186_x_at",0.518537987260825,0.0371105561227498,-2.21799529090685,-3.79140070701615,-1.72396972610188,"PPP2R5A","protein phosphatase 2 regulatory subunit B'alpha",TRUE
+"635_s_at",0.421194407365884,0.0175197547069363,-2.56714656212903,-3.1564212280232,-0.906558885143659,"PPP2R5B","protein phosphatase 2 regulatory subunit B'beta",TRUE
+"204611_s_at",0.812302873476553,0.357413411053119,-0.939880275437387,-5.51834646571009,-0.29597187922436,"PPP2R5B","protein phosphatase 2 regulatory subunit B'beta",TRUE
+"214083_at",0.635916735157933,0.106947450499474,-1.6802879974304,-4.650803309532,-0.558593419668941,"PPP2R5C","protein phosphatase 2 regulatory subunit B'gamma",TRUE
+"213305_s_at",0.659951950356122,0.127765731952804,-1.58223950970708,-4.78876413459913,-0.555170274699918,"PPP2R5C","protein phosphatase 2 regulatory subunit B'gamma",TRUE
+"1554365_a_at",0.667600335207197,0.133975822787815,-1.55558571293104,-4.82515176868101,-0.499710282472849,"PPP2R5C","protein phosphatase 2 regulatory subunit B'gamma",TRUE
+"1554364_at",0.851319596585235,0.454859207165979,-0.760694698796057,-5.66170425601025,-0.630207746796409,"PPP2R5C","protein phosphatase 2 regulatory subunit B'gamma",TRUE
+"1557718_at",0.936992192746977,0.719013446256117,0.36440077067335,-5.87521352513929,0.128261916720446,"PPP2R5C","protein phosphatase 2 regulatory subunit B'gamma",TRUE
+"201877_s_at",0.960138290470901,0.819583313565882,-0.230806138265937,-5.91377016729781,-0.0704459615578319,"PPP2R5C","protein phosphatase 2 regulatory subunit B'gamma",TRUE
+"202513_s_at",0.917806614232276,0.651017176055633,-0.458558931204011,-5.8377813856514,-0.128236820242055,"PPP2R5D","protein phosphatase 2 regulatory subunit B'delta",TRUE
+"211159_s_at",0.954096423385239,0.789394176547704,0.270348835008126,-5.90414733619258,0.0856148528307905,"PPP2R5D","protein phosphatase 2 regulatory subunit B'delta",TRUE
+"203338_at",0.631569426994436,0.10282792240658,-1.70157471320726,-4.62001786308951,-0.448586204470198,"PPP2R5E","protein phosphatase 2 regulatory subunit B'epsilon",TRUE
+"229322_at",0.740476003158683,0.229319989948479,-1.23622606699504,-5.22153776256637,-0.373123514485686,"PPP2R5E","protein phosphatase 2 regulatory subunit B'epsilon",TRUE
+"228070_at",0.861659105448003,0.483171367181183,-0.713192478484646,-5.69493292861385,-0.170819824301921,"PPP2R5E","protein phosphatase 2 regulatory subunit B'epsilon",TRUE
+"227630_at",0.943988850936011,0.749629233713804,-0.323126478314458,-5.88895642887297,-0.115878675080818,"PPP2R5E","protein phosphatase 2 regulatory subunit B'epsilon",TRUE
+"231101_at",0.945498722604777,0.754137112226869,-0.317099029496261,-5.89082672861194,-0.10881495827735,"PPP2R5E","protein phosphatase 2 regulatory subunit B'epsilon",TRUE
+"202457_s_at",0.893175412268596,0.567630233812759,-0.580205717654376,-5.77703603137095,-0.270240819859882,"PPP3CA","protein phosphatase 3 catalytic subunit alpha",TRUE
+"202429_s_at",0.923708852928185,0.67237076929305,-0.428574364244535,-5.85061549943087,-0.197154787778434,"PPP3CA","protein phosphatase 3 catalytic subunit alpha",TRUE
+"202425_x_at",0.975242094553739,0.879891521174456,-0.152860895507665,-5.92830894714505,-0.0557992707266806,"PPP3CA","protein phosphatase 3 catalytic subunit alpha",TRUE
+"202432_at",0.849935057946582,0.452100255988009,0.765416823793586,-5.65829021396642,0.309527698719117,"PPP3CB","protein phosphatase 3 catalytic subunit beta",TRUE
+"209817_at",0.906507435035949,0.614389040821826,0.511023750188284,-5.8132834800535,0.169261806327698,"PPP3CB","protein phosphatase 3 catalytic subunit beta",TRUE
+"235772_at",0.796174477255647,0.328358178451224,0.999469763414502,-5.46450782937247,0.337236941537514,"PPP3CB-AS1","PPP3CB antisense RNA 1 (head to head)",TRUE
+"238522_at",0.993225426079816,0.968200612239337,-0.0403181154436112,-5.93889176608147,-0.0119896655030458,"PPP3CB-AS1","PPP3CB antisense RNA 1 (head to head)",TRUE
+"32540_at",0.603702127972549,0.077664478188492,1.8502116166464,-4.39712366216703,0.684743150764314,"PPP3CC","protein phosphatase 3 catalytic subunit gamma",TRUE
+"209697_at",0.65284137151906,0.122155748704838,1.6072597975183,-4.75416752398619,0.774696820131274,"PPP3CC","protein phosphatase 3 catalytic subunit gamma",TRUE
+"207000_s_at",0.853843408681627,0.462707386480621,0.74735540318044,-5.67124040367858,0.748453251719231,"PPP3CC","protein phosphatase 3 catalytic subunit gamma",TRUE
+"32541_at",0.916664917121013,0.647403939269152,0.463674345310484,-5.83550693877206,0.276678809113085,"PPP3CC","protein phosphatase 3 catalytic subunit gamma",TRUE
+"213950_s_at",0.960455930163982,0.820421874543634,0.229713411766778,-5.91401464328319,0.229489856823472,"PPP3CC","protein phosphatase 3 catalytic subunit gamma",TRUE
+"204506_at",0.862589597763622,0.485558665758957,0.709262639027184,-5.69759072628732,0.318104468750573,"PPP3R1","protein phosphatase 3 regulatory subunit B, alpha",TRUE
+"204507_s_at",0.993063971571452,0.966942275705321,0.04191450550946,-5.93882783191534,0.0134389368992203,"PPP3R1","protein phosphatase 3 regulatory subunit B, alpha",TRUE
+"231304_at",0.644844656970274,0.115160731083267,1.63983897742335,-4.70848989323304,1.10708467183773,"PPP3R2","protein phosphatase 3 regulatory subunit B, beta",TRUE
+"244782_at",0.655745626967443,0.12422025341894,-1.59794294216514,-4.76709969501299,-1.12351530578492,"PPP3R2","protein phosphatase 3 regulatory subunit B, beta",TRUE
+"208932_at",0.66840729430973,0.134586116196723,-1.55302187935879,-4.82862625469696,-0.638295505498146,"PPP4C","protein phosphatase 4 catalytic subunit",TRUE
+"201594_s_at",0.194325783329824,0.00206873010358136,3.4876666053137,-1.29694952853418,1.68767775095272,"PPP4R1","protein phosphatase 4 regulatory subunit 1",TRUE
+"233069_at",0.580137756009815,0.0626335704392733,1.96046975919924,-4.22324340378228,1.25877373048575,"PPP4R1L","protein phosphatase 4 regulatory subunit 1 like (pseudogene)",TRUE
+"223733_s_at",0.615821255316333,0.086547941869114,1.79354094043082,-4.48371168597994,1.11773455261643,"PPP4R1L","protein phosphatase 4 regulatory subunit 1 like (pseudogene)",TRUE
+"1560176_s_at",0.741716158050666,0.23217686785993,1.22842416764683,-5.2302620962882,1.15827729175901,"PPP4R1L","protein phosphatase 4 regulatory subunit 1 like (pseudogene)",TRUE
+"1560175_at",0.972112264314695,0.866153628378794,0.170513707373416,-5.92553207107969,0.0931098064418938,"PPP4R1L","protein phosphatase 4 regulatory subunit 1 like (pseudogene)",TRUE
+"230683_at",0.981158705865426,0.911175399344399,0.112837627313712,-5.93348393431562,0.0993990353203023,"PPP4R1L","protein phosphatase 4 regulatory subunit 1 like (pseudogene)",TRUE
+"225519_at",0.710372201621696,0.183144455158247,-1.37412658400351,-5.0596048110906,-0.553851519763837,"PPP4R2","protein phosphatase 4 regulatory subunit 2",TRUE
+"220764_at",0.83030603167465,0.402617963805745,-0.85331078007026,-5.59112337365853,-0.4755637921367,"PPP4R2","protein phosphatase 4 regulatory subunit 2",TRUE
+"226317_at",0.938726197187622,0.726869501292851,-0.353750965816765,-5.8789156489332,-0.178172484300646,"PPP4R2","protein phosphatase 4 regulatory subunit 2",TRUE
+"223160_s_at",0.689168483917391,0.158224407131008,-1.4603687107844,-4.95111343356484,-0.575916186830117,"PPP4R3A","protein phosphatase 4 regulatory subunit 3A",TRUE
+"220368_s_at",0.798712849674189,0.333187794702678,-0.989320874000135,-5.4738902684146,-0.493890612988952,"PPP4R3A","protein phosphatase 4 regulatory subunit 3A",TRUE
+"220369_at",0.927612926191354,0.682692574979678,0.414224182124214,-5.85645616269183,0.341730098074895,"PPP4R3A","protein phosphatase 4 regulatory subunit 3A",TRUE
+"1568627_at",0.627092759817312,0.0984645720619764,-1.72492687971451,-4.58591104160101,-0.68174808108557,"PPP4R3B","protein phosphatase 4 regulatory subunit 3B",TRUE
+"226230_at",0.846331475285199,0.444401803646379,0.778686205725493,-5.648589821549,0.213764430664591,"PPP4R3B","protein phosphatase 4 regulatory subunit 3B",TRUE
+"224474_x_at",0.851898171464993,0.457031802158501,0.756988286877028,-5.66436995399996,0.19986510810063,"PPP4R3B","protein phosphatase 4 regulatory subunit 3B",TRUE
+"233759_s_at",0.854184492233394,0.464465431567433,0.744385886229037,-5.67334154137008,0.208041667569384,"PPP4R3B","protein phosphatase 4 regulatory subunit 3B",TRUE
+"222270_at",0.975398143273847,0.882154942998788,-0.149957379737139,-5.92873671863998,-0.0755038317263859,"PPP4R3B","protein phosphatase 4 regulatory subunit 3B",TRUE
+"241103_at",0.986342822130003,0.933536208082739,0.0843493104902739,-5.93621871503325,0.066872959398999,"PPP4R3B","protein phosphatase 4 regulatory subunit 3B",TRUE
+"1562054_at",0.853768202875953,0.462404990476806,0.747866857945367,-5.67087771411032,0.654847892458023,"PPP4R3CP","protein phosphatase 4 regulatory subunit 3C, pseudogene",TRUE
+"220672_at",0.70831396447436,0.180203881954062,1.38379633747696,-5.04771160339915,1.01539599336421,"PPP4R4","protein phosphatase 4 regulatory subunit 4",TRUE
+"233002_at",0.940044918888428,0.731561290981192,0.347410603816099,-5.88106818844643,0.638175568857846,"PPP4R4","protein phosphatase 4 regulatory subunit 4",TRUE
+"220673_s_at",0.944654135079729,0.75121384799509,0.321006322538335,-5.88961828243815,0.444826533831528,"PPP4R4","protein phosphatase 4 regulatory subunit 4",TRUE
+"215705_at",0.839519981963042,0.427666930960427,0.808024731987234,-5.62658516114304,0.330327327846055,"PPP5C","protein phosphatase 5 catalytic subunit",TRUE
+"201979_s_at",0.97763916244156,0.892180104161863,0.137112608054288,-5.9305309048017,0.0451928395929588,"PPP5C","protein phosphatase 5 catalytic subunit",TRUE
+"1566544_at",0.425751189365875,0.0182409828161747,-2.54885880707399,-3.19090944991193,-1.79719507855807,"PPP5D1","PPP5 tetratricopeptide repeat domain containing 1",TRUE
+"242253_at",0.840135531063827,0.429172114908325,0.805357215069657,-5.62861748201177,0.255433039943541,"PPP5D1","PPP5 tetratricopeptide repeat domain containing 1",TRUE
+"225426_at",0.384586587899771,0.0125647150294399,-2.71614576390723,-2.87098527872106,-0.922033008955879,"PPP6C","protein phosphatase 6 catalytic subunit",TRUE
+"206174_s_at",0.405987580040004,0.0152073628517957,-2.63094857929403,-3.03514376947489,-0.753373635246049,"PPP6C","protein phosphatase 6 catalytic subunit",TRUE
+"225429_at",0.501591596209182,0.0322513831877897,-2.28486300121812,-3.67388260721937,-0.852493478545334,"PPP6C","protein phosphatase 6 catalytic subunit",TRUE
+"203529_at",0.597346378847428,0.0732438316736489,-1.88054399175987,-4.34999063905772,-0.542569342086994,"PPP6C","protein phosphatase 6 catalytic subunit",TRUE
+"209229_s_at",0.717383438122835,0.193178534238363,-1.34202811004162,-5.09858509887059,-0.391878096672936,"PPP6R1","protein phosphatase 6 regulatory subunit 1",TRUE
+"238110_at",0.846015118644589,0.444026176140312,-0.779337217528597,-5.64810986084624,-0.449353155538275,"PPP6R2","protein phosphatase 6 regulatory subunit 2",TRUE
+"202792_s_at",0.915939421175188,0.645165563681755,-0.466849612387174,-5.83408270114451,-0.246709358314527,"PPP6R2","protein phosphatase 6 regulatory subunit 2",TRUE
+"202791_s_at",0.940938843113333,0.735458402658908,-0.342155174971005,-5.88282322780853,-0.116474059838993,"PPP6R2","protein phosphatase 6 regulatory subunit 2",TRUE
+"1570210_x_at",0.957571530817866,0.809169756199162,0.24440044292267,-5.9106322362544,0.0971525440574537,"PPP6R2","protein phosphatase 6 regulatory subunit 2",TRUE
+"217928_s_at",0.877223961993707,0.526467000763794,0.643559242283133,-5.73994590956446,0.178168262521972,"PPP6R3","protein phosphatase 6 regulatory subunit 3",TRUE
+"232312_at",0.889810959543386,0.558070555348921,0.594697441178296,-5.76887894889325,0.397786822472018,"PPP6R3","protein phosphatase 6 regulatory subunit 3",TRUE
+"222467_s_at",0.99691938672319,0.984350070719745,0.0198381267514576,-5.93949179825202,0.00651107581818167,"PPP6R3","protein phosphatase 6 regulatory subunit 3",TRUE
+"203737_s_at",0.710672261019989,0.183843906073123,1.37184464632287,-5.06240134674424,0.43418557873091,"PPRC1","peroxisome proliferator-activated receptor gamma, coactivator-related 1",TRUE
+"200975_at",0.694347113196495,0.163668728650464,-1.44064203155442,-4.97640622017633,-0.6775388164296,"PPT1","palmitoyl-protein thioesterase 1",TRUE
+"208469_s_at",0.79279559916191,0.324643145454633,-1.00734709303849,-5.45716550648783,-0.469748173189436,"PPT2-EGFL8///EGFL8///PPT2","PPT2-EGFL8 readthrough (NMD candidate)///EGF like domain multiple 8///palmitoyl-protein thioesterase 2",TRUE
+"209826_at",0.95018792835023,0.773680273974843,0.291102906083192,-5.8984933874263,0.152488219954994,"PPT2-EGFL8///EGFL8///PPT2","PPT2-EGFL8 readthrough (NMD candidate)///EGF like domain multiple 8///palmitoyl-protein thioesterase 2",TRUE
+"225204_at",0.812302873476553,0.357029704181976,0.940645346235411,-5.51767442107083,0.302132617677405,"PPTC7","PTC7 protein phosphatase homolog",TRUE
+"225213_at",0.820536502908875,0.379889308656045,0.895990912899298,-5.55605566264687,0.318125215475291,"PPTC7","PTC7 protein phosphatase homolog",TRUE
+"235744_at",0.865540137051525,0.495402246034985,0.693175250130247,-5.70832484290636,0.325303104590461,"PPTC7","PTC7 protein phosphatase homolog",TRUE
+"236999_at",0.948668195792872,0.766347936282403,-0.30083134630536,-5.89570038555409,-0.278249926075836,"PPWD1","peptidylprolyl isomerase domain and WD repeat containing 1",TRUE
+"213483_at",0.970135831114343,0.858257016972237,-0.180685424585097,-5.92379472080155,-0.0510152052576398,"PPWD1","peptidylprolyl isomerase domain and WD repeat containing 1",TRUE
+"210670_at",0.68744166438792,0.15606318323836,1.46835196834391,-4.940798247535,0.464939450554811,"PPY","pancreatic polypeptide",TRUE
+"220654_at",0.864894115958506,0.493823142950793,-0.695743550573564,-5.70662693341251,-0.435389839650258,"PPY2P","pancreatic polypeptide 2, pseudogene",TRUE
+"214527_s_at",0.635368778245437,0.106504889851293,-1.68254116134075,-4.6475585682026,-0.463017490779528,"PQBP1","polyglutamine binding protein 1",TRUE
+"207769_s_at",0.731314021977412,0.214449647539383,-1.27807837732386,-5.17392842044344,-0.384044521022924,"PQBP1","polyglutamine binding protein 1",TRUE
+"210499_s_at",0.992376456171815,0.964418937189594,-0.0451160824708961,-5.93869213142093,-0.0130590383028082,"PQBP1","polyglutamine binding protein 1",TRUE
+"230181_at",0.839466826665106,0.425761861630032,0.811409326929427,-5.6239974355573,0.510219633153832,"PQLC1","PQ loop repeat containing 1",TRUE
+"218208_at",0.936143408699214,0.715078426732367,-0.369751257162518,-5.87331265758968,-0.126685530183391,"PQLC1","PQ loop repeat containing 1",TRUE
+"220453_at",0.784789297644843,0.309322585335,1.04051455276663,-5.42567932033049,0.334203955589905,"PQLC2","PQ loop repeat containing 2",TRUE
+"1555781_at",0.8288884913487,0.399701409553582,-0.858698843590649,-5.58678407798797,-0.262177575836144,"PQLC2","PQ loop repeat containing 2",TRUE
+"1555783_x_at",0.907294413494963,0.61646611070509,-0.508010850575323,-5.81476039078752,-0.149328182502019,"PQLC2","PQ loop repeat containing 2",TRUE
+"238969_at",0.130668376232398,0.000801527344431644,3.87895052456321,-0.461451393532479,2.4657057055022,"PQLC2L","PQ loop repeat containing 2 like",TRUE
+"1558552_s_at",0.67818193964437,0.145517633401593,1.5086461612069,-4.88804281645324,1.06517805535636,"PQLC2L","PQ loop repeat containing 2 like",TRUE
+"216694_at",0.89967769475675,0.591045029904274,0.545225884451759,-5.79592167280556,0.168469291623599,"PQLC3","PQ loop repeat containing 3",TRUE
+"225579_at",0.91876780831279,0.655054206742622,-0.452858183465705,-5.84028695285366,-0.339552738481208,"PQLC3","PQ loop repeat containing 3",TRUE
+"216458_at",0.920564553801456,0.662296904594053,0.442668587491944,-5.84468886320178,0.34921565889522,"PQLC3","PQ loop repeat containing 3",TRUE
+"230784_at",0.728385463227073,0.208851104499993,1.2944142364626,-5.15497848076475,0.635737672692875,"PRAC1","prostate cancer susceptibility candidate 1",TRUE
+"223312_at",0.542277271596324,0.045435247941157,-2.12003984180674,-3.95968066253867,-0.746176150721466,"PRADC1","protease associated domain containing 1",TRUE
+"203456_at",0.679041081350052,0.146609181525605,-1.5043669226972,-4.8936998547029,-0.714036877320366,"PRAF2","PRA1 domain family member 2",TRUE
+"241742_at",0.909052380289506,0.622783797921125,0.49887577157299,-5.81918628021243,0.254978719406191,"PRAM1","PML-RARA regulated adaptor molecule 1",TRUE
+"204086_at",0.96524703089691,0.8380303851787,-0.206831552235579,-5.91886871897422,-0.364271098404863,"PRAME","preferentially expressed antigen in melanoma",TRUE
+"217273_at",0.599731655615302,0.0760814668041197,1.86089629813025,-4.38058280169138,1.23576334959515,"PRAMEF10","PRAME family member 10",TRUE
+"217365_at",0.957571530817866,0.809371186340269,0.24413704878364,-5.91069473076175,0.0618473977551783,"PRAMEF11","PRAME family member 11",TRUE
+"216001_at",0.937113154905832,0.720504839353638,0.362375745477572,-5.87592582046785,0.249649500324103,"PRAMEF12","PRAME family member 12",TRUE
+"208312_s_at",0.929385267595748,0.68950257891171,-0.404804776025995,-5.86018359331189,-0.185447753120427,"PRAMEF2///PRAMEF1","PRAME family member 2///PRAME family member 1",TRUE
+"243669_s_at",0.519082612629108,0.037325690068032,2.21522325057036,-3.79622713727771,1.31598738282988,"PRAP1","proline rich acidic protein 1",TRUE
+"211531_x_at",0.744573608322482,0.235551661492157,1.21930113752446,-5.24040324884117,0.431777273863657,"PRB1","proline rich protein BstNI subfamily 1",TRUE
+"210597_x_at",0.85334340854827,0.460636080036772,0.750862694874481,-5.66874854673717,0.305696655068518,"PRB1","proline rich protein BstNI subfamily 1",TRUE
+"207752_x_at",0.968035667633768,0.849309551211763,0.192234445063439,-5.92170052154365,0.0964426194943249,"PRB1","proline rich protein BstNI subfamily 1",TRUE
+"206998_x_at",0.973108874852577,0.870841227940773,-0.164484324274878,-5.92651452743479,-0.0804832695988615,"PRB3","proline rich protein BstNI subfamily 3",TRUE
+"216881_x_at",0.929385267595748,0.689516545004559,0.404785497046188,-5.86019113583169,0.188457545619247,"PRB4","proline rich protein BstNI subfamily 4",TRUE
+"218009_s_at",0.962555471240652,0.829808454073092,-0.217500951342159,-5.9166683802045,-0.0716198441664453,"PRC1","protein regulator of cytokinesis 1",TRUE
+"244667_at",0.604775837099205,0.0788006047278415,1.842659449939,-4.40877421114215,1.14125541533307,"PRCAT47","prostate cancer-associated 47",TRUE
+"208938_at",0.446963972064621,0.0210985520404723,-2.48247889905288,-3.31502625851401,-0.880135863564075,"PRCC","papillary renal cell carcinoma (translocation-associated)",TRUE
+"1556727_at",0.70573152022539,0.178067662322867,1.39089990889002,-5.03893059189133,0.551000539378332,"PRCD","progressive rod-cone degeneration",TRUE
+"230015_at",0.933540218773015,0.705734208734249,0.382501207108599,-5.86867280679265,0.308150918037985,"PRCD","progressive rod-cone degeneration",TRUE
+"231588_at",0.680123633607363,0.14726993503937,1.50178918474359,-4.89710134385543,1.30708383625668,"PRCP","prolylcarboxypeptidase",TRUE
+"242636_at",0.860714927752408,0.480357610584907,0.717838828648323,-5.69177251287215,0.378872250230998,"PRCP","prolylcarboxypeptidase",TRUE
+"201494_at",0.940129109769338,0.731813350009749,0.347070390725807,-5.88118260243005,0.226795737405974,"PRCP","prolylcarboxypeptidase",TRUE
+"1569205_at",0.965992617204023,0.840877886037698,0.203142202351228,-5.91960393046691,0.148182968008889,"PRCP","prolylcarboxypeptidase",TRUE
+"217192_s_at",0.396029420177575,0.0135957425088854,2.68105918404104,-2.93888703421728,1.38627217738636,"PRDM1","PR/SET domain 1",TRUE
+"228964_at",0.468591857727704,0.0246758879855877,2.41028516446575,-3.4480363037432,1.66137479899091,"PRDM1","PR/SET domain 1",TRUE
+"235668_at",0.748184017928985,0.240290587444166,1.20665582022172,-5.25435152041639,0.819616099121473,"PRDM1","PR/SET domain 1",TRUE
+"219515_at",0.690015152288705,0.159592043931099,-1.45536233767985,-4.95755889829155,-0.376965665984194,"PRDM10","PR/SET domain 10",TRUE
+"214158_s_at",0.959515701539076,0.817045795713395,0.234114527784293,-5.91302294326908,0.158996858139315,"PRDM10","PR/SET domain 10",TRUE
+"229688_at",0.385141328160291,0.0126438789473484,-2.71335708285657,-2.87639695314401,-1.95564446817505,"PRDM11","PR/SET domain 11",TRUE
+"229687_s_at",0.497871139123625,0.0309132178193963,-2.30489601908682,-3.63827433914052,-1.48827740006581,"PRDM11","PR/SET domain 11",TRUE
+"1559567_at",0.960588243569671,0.820815375122054,-0.229200740901835,-5.91412894544888,-0.0675919164854708,"PRDM11","PR/SET domain 11",TRUE
+"220571_at",0.962555471240652,0.829415921054579,-0.21801096820909,-5.91656044123654,-0.153067482055406,"PRDM11","PR/SET domain 11",TRUE
+"233067_at",0.983498417373669,0.91933608296883,0.102430865760191,-5.93457446607201,0.0730409893118864,"PRDM11","PR/SET domain 11",TRUE
+"220894_x_at",0.61810433367952,0.0890047630371991,1.77875820664355,-4.5059774412682,0.796247171279425,"PRDM12","PR/SET domain 12",TRUE
+"221168_at",0.55937703282623,0.0532293487662834,2.04203072344598,-4.09022434870302,2.04598258061208,"PRDM13","PR/SET domain 13",TRUE
+"220714_at",0.972819824894874,0.868335979747306,-0.16770588633773,-5.92599397870433,-0.110839708494151,"PRDM14","PR/SET domain 14",TRUE
+"231931_at",0.51531387545335,0.0357950116003388,-2.23527142770365,-3.76123876230428,-0.695351274414686,"PRDM15","PR/SET domain 15",TRUE
+"234524_at",0.527546822913581,0.0399895753859492,2.18205025216652,-3.85369843638126,1.19287387007315,"PRDM15","PR/SET domain 15",TRUE
+"230553_at",0.730053120402013,0.212600014321735,1.28343856370488,-5.16773307430827,0.777841827287307,"PRDM15","PR/SET domain 15",TRUE
+"230777_s_at",0.737123149977386,0.223025976008365,-1.25367918942092,-5.20184908309368,-0.387082151979364,"PRDM15","PR/SET domain 15",TRUE
+"236061_at",0.932249295738588,0.701128632733684,-0.388809098554851,-5.86631995335213,-0.12493125467091,"PRDM15","PR/SET domain 15",TRUE
+"220928_s_at",0.745083412128071,0.236832274702766,1.21586515831483,-5.24420572843541,0.856552103029149,"PRDM16","PR/SET domain 16",TRUE
+"232424_at",0.845487921422997,0.442688138407394,-0.781658948437139,-5.64639507761601,-0.830731349158687,"PRDM16","PR/SET domain 16",TRUE
+"216445_at",0.707596006786505,0.179050585347806,1.38762303103161,-5.04298590068247,0.792571507771427,"PRDM2","PR/SET domain 2",TRUE
+"203057_s_at",0.726945310232634,0.20709464118937,1.29960915335136,-5.14890941982423,0.358192751685825,"PRDM2","PR/SET domain 2",TRUE
+"205277_at",0.755639383619058,0.24977749193787,1.1818941859825,-5.28129832025006,0.39719274901142,"PRDM2","PR/SET domain 2",TRUE
+"216433_s_at",0.940668681806864,0.734399324796929,-0.343582410512351,-5.88234922146564,-0.332191677822558,"PRDM2","PR/SET domain 2",TRUE
+"203056_s_at",0.989143455305063,0.947102052069462,-0.0671023663280728,-5.93749060611476,-0.0205331288206949,"PRDM2","PR/SET domain 2",TRUE
+"1565840_at",0.90344422113846,0.603837423283787,0.526404459923139,-5.80561131082713,0.334117642130042,"PRDM4","PR/SET domain 4",TRUE
+"218329_at",0.92186037171741,0.666824981089197,-0.436322307175761,-5.84738078162266,-0.149980538839872,"PRDM4","PR/SET domain 4",TRUE
+"49485_at",0.993615552413264,0.969810399682987,-0.0382760127475978,-5.9389699325676,-0.0102879227380068,"PRDM4","PR/SET domain 4",TRUE
+"220792_at",0.598618215299661,0.0755755172969068,1.86435210718292,-4.37521844180475,0.606004095702598,"PRDM5","PR/SET domain 5",TRUE
+"235764_at",0.627092759817312,0.0983858225473864,1.72535637599733,-4.5852804932343,1.54917110831167,"PRDM5","PR/SET domain 5",TRUE
+"1569508_at",0.636147339487472,0.107520199186539,-1.67738370943092,-4.65498086745365,-1.32547058962524,"PRDM5","PR/SET domain 5",TRUE
+"236577_at",0.468735421183467,0.0250362308829029,-2.40356075292438,-3.4603165932999,-1.25501203795175,"PRDM6","PR/SET domain 6",TRUE
+"230311_s_at",0.55937703282623,0.0532405561475544,-2.04192612645727,-4.09039724372044,-2.53753844579069,"PRDM6","PR/SET domain 6",TRUE
+"232374_s_at",0.952613441433926,0.782728577106408,0.279137052336305,-5.9018038379028,0.198968505194525,"PRDM6","PR/SET domain 6",TRUE
+"224228_s_at",0.791353982620776,0.321843980774313,-1.01332393941694,-5.45155974549236,-0.512554657154562,"PRDM7","PR/SET domain 7",TRUE
+"219835_at",0.863559206655094,0.488726338025214,0.704065402364727,-5.70108419266433,0.23718198890195,"PRDM8","PR/SET domain 8",TRUE
+"239111_at",0.91101836045758,0.628752362075734,0.49028486906885,-5.82327697022486,0.269837670989539,"PRDM8","PR/SET domain 8",TRUE
+"221151_at",0.975581031952184,0.88365248185401,-0.148037064917048,-5.92901513922983,-0.0983047912128301,"PRDM9","PR/SET domain 9",TRUE
+"208680_at",0.995776165684507,0.979637534471402,-0.0258130472237018,-5.93935894926641,-0.0066392346403763,"PRDX1","peroxiredoxin 1",TRUE
+"215067_x_at",0.849935057946582,0.451857621634361,0.765832939413245,-5.65798840992328,0.563029002230223,"PRDX2","peroxiredoxin 2",TRUE
+"39729_at",0.936456142259101,0.716449437765562,-0.3678858390831,-5.87397849003529,-0.128578434839392,"PRDX2","peroxiredoxin 2",TRUE
+"211658_at",0.954387719376857,0.790226181159711,-0.269253423468191,-5.90443422587448,-0.129971739048367,"PRDX2","peroxiredoxin 2",TRUE
+"201006_at",0.99595107735282,0.980121511989865,-0.0251993822317479,-5.93937419607653,-0.0119611773668131,"PRDX2","peroxiredoxin 2",TRUE
+"209766_at",0.866602763987519,0.497748803282953,0.689367352970809,-5.71083121865494,0.205720928220451,"PRDX3","peroxiredoxin 3",TRUE
+"201619_at",0.914632961724784,0.640535822669263,0.473432707463858,-5.83109959844208,0.168741841062968,"PRDX3","peroxiredoxin 3",TRUE
+"201923_at",0.850536169066796,0.453338241647367,-0.763295786904957,-5.65982616968049,-0.250897593334976,"PRDX4","peroxiredoxin 4",TRUE
+"1560587_s_at",0.841967750949524,0.434776228056054,-0.79547620409485,-5.63609057575481,-0.277463922449408,"PRDX5","peroxiredoxin 5",TRUE
+"222994_at",0.941106542715586,0.736046049649834,-0.341363562210959,-5.88308529314801,-0.123864709128378,"PRDX5","peroxiredoxin 5",TRUE
+"200844_s_at",0.726636642789909,0.206032500259616,1.30276713979362,-5.14520996762158,0.384555876126646,"PRDX6","peroxiredoxin 6",TRUE
+"200845_s_at",0.78578093265889,0.311293631631651,1.03618367204631,-5.42984289479648,0.266263179277569,"PRDX6","peroxiredoxin 6",TRUE
+"217861_s_at",0.998047179825832,0.991345817234017,-0.0109696728644171,-5.93962487079936,-0.0032652825053745,"PREB","prolactin regulatory element binding",TRUE
+"223032_x_at",0.61760967235709,0.0881655460916653,-1.78376780501361,-4.49844703638178,-0.508771742611332,"PRELID1","PRELI domain containing 1",TRUE
+"224232_s_at",0.690381347688918,0.160013020636588,-1.45382829215686,-4.95953030879767,-0.648074473265,"PRELID1","PRELI domain containing 1",TRUE
+"235828_at",0.65284137151906,0.122100481559224,1.60751101222148,-4.75381802005935,0.439475482162111,"PRELID2","PRELI domain containing 2",TRUE
+"236513_at",0.792305111661886,0.323414092036031,1.00996695967544,-5.45471199720415,0.347933557773038,"PRELID2","PRELI domain containing 2",TRUE
+"206273_at",0.922414697359657,0.668508136861022,-0.433967945612098,-5.84836973252352,-0.372015970469259,"PRELID3A","PRELI domain containing 3A",TRUE
+"229835_s_at",0.554642754132296,0.0509068095667484,-2.06414312191328,-4.05354310597295,-1.25822644346236,"PRELID3B","PRELI domain containing 3B",TRUE
+"217851_s_at",0.818852235468236,0.372573205668183,-0.91008330475506,-5.54412888749164,-0.305585061177295,"PRELID3B","PRELI domain containing 3B",TRUE
+"222441_x_at",0.917102138198416,0.649255085480337,-0.461052037999888,-5.83667597310237,-0.149245940575247,"PRELID3B","PRELI domain containing 3B",TRUE
+"204223_at",0.821137675198948,0.381981425506541,-0.891993937631872,-5.55940707510216,-0.561591171758977,"PRELP","proline and arginine rich end leucine rich repeat protein",TRUE
+"228224_at",0.892907360745386,0.566577687541649,0.581795108944696,-5.77615090232696,0.34687958880794,"PRELP","proline and arginine rich end leucine rich repeat protein",TRUE
+"37022_at",0.904200961286352,0.60653817020829,0.522455569277152,-5.80760223227265,0.185971076946909,"PRELP","proline and arginine rich end leucine rich repeat protein",TRUE
+"229644_at",0.743553048228796,0.233973532751561,1.22355486125174,-5.23568294256382,0.736691929512409,"PREP","prolyl endopeptidase",TRUE
+"37950_at",0.795789774251253,0.328038590435752,1.00014497629111,-5.46388052414912,0.38138436824717,"PREP","prolyl endopeptidase",TRUE
+"204117_at",0.897699110987203,0.585221672985235,0.553859795291593,-5.79136610457091,0.234092034260268,"PREP","prolyl endopeptidase",TRUE
+"212217_at",0.770525343471192,0.278969721453221,-1.10983705453229,-5.35692144636346,-0.533278679730923,"PREPL","prolyl endopeptidase-like",TRUE
+"212215_at",0.865187396415238,0.494445804521224,-0.694730275524494,-5.70729752775313,-0.33763229399862,"PREPL","prolyl endopeptidase-like",TRUE
+"212216_at",0.893600768892136,0.568795539940296,-0.578447812110486,-5.77801227570474,-0.202637905203613,"PREPL","prolyl endopeptidase-like",TRUE
+"243542_at",0.9802233499944,0.907106217941387,0.118031475648275,-5.9329002724178,0.0780818521315538,"PREPL","prolyl endopeptidase-like",TRUE
+"224909_s_at",0.411110107932987,0.0160624576213019,-2.60635671124476,-3.08206217875187,-3.96236292272565,"PREX1","phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1",TRUE
+"224925_at",0.562638706929609,0.0551613821814933,-2.02428295546606,-4.11947707675937,-3.08987282246621,"PREX1","phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1",TRUE
+"1569934_at",0.280199223932988,0.0046930899711568,-3.14337457112002,-2.01555534335948,-2.56564932097047,"PREX2","phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2",TRUE
+"220732_at",0.786796445263724,0.312455446887321,-1.03363992459693,-5.43228108053863,-0.601120040881571,"PREX2","phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2",TRUE
+"228692_at",0.937203701144735,0.721130991293258,-0.361526011934906,-5.87622354381479,-0.529497065751067,"PREX2","phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2",TRUE
+"233408_at",0.98539961718117,0.928682025620941,0.0905267731899114,-5.93569273943733,0.0750005810802037,"PREX2","phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2",TRUE
+"1553681_a_at",0.833864906769924,0.411556369623894,0.836951715709204,-5.60414206916254,0.255380439555695,"PRF1","perforin 1",TRUE
+"214617_at",0.943294768503521,0.745325848669188,-0.328891912992168,-5.88713481120911,-0.205432913474845,"PRF1","perforin 1",TRUE
+"211743_s_at",0.760337658876104,0.259024530285462,1.15842563769798,-5.30638725156399,0.728533296681951,"PRG2","proteoglycan 2, pro eosinophil major basic protein",TRUE
+"220811_at",0.925091998149497,0.675558292604271,0.424133189476859,-5.85244398969568,0.265333136059586,"PRG3","proteoglycan 3, pro eosinophil major basic protein 2",TRUE
+"206007_at",0.839519981963042,0.4263000581284,-0.810452198326596,-5.62473024711036,-0.628470389091828,"PRG4","proteoglycan 4",TRUE
+"205272_s_at",0.960562263851505,0.820751482036593,0.229283979511882,-5.91411040432245,0.0743349306719541,"PRH1-PRR4///PRH2///PRH1","PRH1-PRR4 readthrough///proline rich protein HaeIII subfamily 2///proline rich protein HaeIII subfamily 1",TRUE
+"204919_at",0.997658807362705,0.988557228627418,0.014504596319454,-5.93958101131291,0.00604293738012807,"PRH1-PRR4///PRR4","PRH1-PRR4 readthrough///proline rich 4 (lacrimal)",TRUE
+"243389_at",0.317600554649094,0.00692959139081535,2.97644868148061,-2.35550504253246,1.80706842739034,"PRH1-PRR4///PRR4///PRH1","PRH1-PRR4 readthrough///proline rich 4 (lacrimal)///proline rich protein HaeIII subfamily 1",TRUE
+"230708_at",0.801086839730802,0.337501826653258,0.980340901438461,-5.48211942662685,0.797375492352993,"PRICKLE1","prickle planar cell polarity protein 1",TRUE
+"232811_x_at",0.832855340883376,0.4099917969799,-0.839798744366307,-5.6018932862587,-0.294661919791817,"PRICKLE1","prickle planar cell polarity protein 1",TRUE
+"226069_at",0.841967750949524,0.434648953695828,0.795699733535646,-5.63592247742437,1.20679030776608,"PRICKLE1","prickle planar cell polarity protein 1",TRUE
+"226065_at",0.853768202875953,0.462506019318063,0.747695961543839,-5.67099892857659,0.582111976183638,"PRICKLE1","prickle planar cell polarity protein 1",TRUE
+"225968_at",0.930827859648584,0.693644078053077,-0.399094593021354,-5.86240212889262,-0.287521052266568,"PRICKLE2","prickle planar cell polarity protein 2",TRUE
+"1561676_at",0.993474831312851,0.969428354885767,0.0387606418685655,-5.93895174975258,0.0317639038215733,"PRICKLE2-AS3","PRICKLE2 antisense RNA 3",TRUE
+"217349_s_at",0.76912869907427,0.274717153124672,1.11997804691228,-5.34653238054439,0.458508459173128,"PRICKLE3","prickle planar cell polarity protein 3",TRUE
+"205053_at",0.959584210327095,0.817405020563647,0.233646012651016,-5.91312940383596,0.0872798330445317,"PRIM1","primase (DNA) subunit 1",TRUE
+"205628_at",0.606138724709726,0.079688441299695,1.83682334450188,-4.41775413310006,0.641896891356954,"PRIM2","primase (DNA) subunit 2",TRUE
+"1554885_a_at",0.540483367247649,0.0449318597719071,2.12548198614767,-3.950456516733,0.863984649624136,"PRIM2B///PRIM2","primase (DNA) subunit 2 pseudogene///primase (DNA) subunit 2",TRUE
+"215708_s_at",0.694347113196495,0.163671615818499,1.44063171170926,-4.97641937852861,0.627030118950728,"PRIM2B///PRIM2","primase (DNA) subunit 2 pseudogene///primase (DNA) subunit 2",TRUE
+"215709_at",0.937190541859459,0.721023922318725,-0.36167129305018,-5.8761726902066,-0.231273057547874,"PRIM2B///PRIM2","primase (DNA) subunit 2 pseudogene///primase (DNA) subunit 2",TRUE
+"1554884_at",0.955767623518136,0.798317253421605,-0.258618082862087,-5.90715948770497,-0.135325882527004,"PRIM2B///PRIM2","primase (DNA) subunit 2 pseudogene///primase (DNA) subunit 2",TRUE
+"230087_at",0.580748061056528,0.0634573640459237,-1.95385333450369,-4.23387357203337,-1.1058351937583,"PRIMA1","proline rich membrane anchor 1",TRUE
+"227157_at",0.955892698633978,0.799650342227839,0.256868753426376,-5.90759729782068,0.110463433918762,"PRIMPOL","primase and DNA directed polymerase",TRUE
+"216051_x_at",0.940900986249919,0.735295380962788,0.342374819175064,-5.88275040768622,0.154728288563398,"PRINS","psoriasis associated non-protein coding RNA induced by stress",TRUE
+"209799_at",0.332566035407083,0.00818104934958725,2.90455159295081,-2.49980966664012,1.40416875474083,"PRKAA1","protein kinase AMP-activated catalytic subunit alpha 1",TRUE
+"225985_at",0.364513221153898,0.0106591429998064,2.78884232718921,-2.7290350648154,1.17341985808672,"PRKAA1","protein kinase AMP-activated catalytic subunit alpha 1",TRUE
+"225984_at",0.527546822913581,0.0401345283412802,2.18030326788276,-3.85671025530261,1.20575987190438,"PRKAA1","protein kinase AMP-activated catalytic subunit alpha 1",TRUE
+"214917_at",0.68270002258037,0.15056235706034,1.48908373275038,-4.91379856842079,1.38620689882435,"PRKAA1","protein kinase AMP-activated catalytic subunit alpha 1",TRUE
+"1555177_at",0.753931998274535,0.247329522885627,1.1882151911658,-5.27446575218506,0.975063317117046,"PRKAA1","protein kinase AMP-activated catalytic subunit alpha 1",TRUE
+"240349_at",0.910292496128599,0.627190281146053,0.492529625347086,-5.82221479327403,0.591059017113645,"PRKAA2","protein kinase AMP-activated catalytic subunit alpha 2",TRUE
+"207709_at",0.94630837494651,0.756846542202302,0.313482045001332,-5.89193232413987,0.152854142341106,"PRKAA2","protein kinase AMP-activated catalytic subunit alpha 2",TRUE
+"227892_at",0.965417082126351,0.838619458591841,-0.206068083057037,-5.91902194406501,-0.199122579492299,"PRKAA2","protein kinase AMP-activated catalytic subunit alpha 2",TRUE
+"238441_at",0.967106491969364,0.846826214961743,-0.195444513398243,-5.92109547913037,-0.313398707705045,"PRKAA2","protein kinase AMP-activated catalytic subunit alpha 2",TRUE
+"238489_at",0.986342822130003,0.9351415913915,0.082307041628208,-5.93638443494577,0.0573460349707418,"PRKAA2","protein kinase AMP-activated catalytic subunit alpha 2",TRUE
+"201834_at",0.820291269575398,0.37898501781961,-0.897723029803371,-5.55459899935861,-0.391822939543934,"PRKAB1","protein kinase AMP-activated non-catalytic subunit beta 1",TRUE
+"201835_s_at",0.861981304384929,0.484704758136909,-0.710667006128489,-5.69664254178093,-0.258890706509984,"PRKAB1","protein kinase AMP-activated non-catalytic subunit beta 1",TRUE
+"1558027_s_at",0.8705868625915,0.509804839132914,-0.669961816974165,-5.72339896744102,-0.235357128425377,"PRKAB2","protein kinase AMP-activated non-catalytic subunit beta 2",TRUE
+"214474_at",0.918409982899324,0.653663053661041,0.454820920205283,-5.83942776750375,0.163517438754078,"PRKAB2","protein kinase AMP-activated non-catalytic subunit beta 2",TRUE
+"225278_at",0.962950730986158,0.831897847780525,-0.214787198043277,-5.9172384813912,-0.0791634098885243,"PRKAB2","protein kinase AMP-activated non-catalytic subunit beta 2",TRUE
+"216234_s_at",0.626983082753167,0.0974733644883754,1.73035439698669,-4.5779342491798,0.716238350858,"PRKACA","protein kinase cAMP-activated catalytic subunit alpha",TRUE
+"202801_at",0.828607509614823,0.398880252187108,0.860220409433977,-5.58555407438874,0.266160573438299,"PRKACA","protein kinase cAMP-activated catalytic subunit alpha",TRUE
+"202742_s_at",0.895657764833717,0.575146122117966,0.568899805074893,-5.78326459649485,0.455131576495187,"PRKACB","protein kinase cAMP-activated catalytic subunit beta",TRUE
+"235780_at",0.899046682581382,0.589132881875978,0.54805625048325,-5.79443592743487,0.329042179118397,"PRKACB","protein kinase cAMP-activated catalytic subunit beta",TRUE
+"202741_at",0.941833562132083,0.738971533467986,0.337425971411912,-5.88437992285122,0.227136665206128,"PRKACB","protein kinase cAMP-activated catalytic subunit beta",TRUE
+"207228_at",0.728262401376535,0.208542822279799,1.29532355642303,-5.15391764002274,0.739326881263269,"PRKACG","protein kinase cAMP-activated catalytic subunit gamma",TRUE
+"201805_at",0.67368843181164,0.140189618920221,-1.52991925515282,-4.85973012618363,-0.499918110872651,"PRKAG1","protein kinase AMP-activated non-catalytic subunit gamma 1",TRUE
+"215231_at",0.676475496596199,0.143466234260821,1.5167599285624,-4.87728137647733,1.26514967710842,"PRKAG2","protein kinase AMP-activated non-catalytic subunit gamma 2",TRUE
+"218292_s_at",0.789661545166663,0.317022495819544,1.02370455196552,-5.44175234804245,0.525288097795478,"PRKAG2","protein kinase AMP-activated non-catalytic subunit gamma 2",TRUE
+"233748_x_at",0.819018525257656,0.375150892118916,0.905097458010106,-5.54836820151897,0.456952541464512,"PRKAG2","protein kinase AMP-activated non-catalytic subunit gamma 2",TRUE
+"222582_at",0.906989884330247,0.615426479335916,0.50951829356545,-5.81402251320999,0.309167168384928,"PRKAG2","protein kinase AMP-activated non-catalytic subunit gamma 2",TRUE
+"231224_x_at",0.953564723226096,0.786268202723786,-0.274467504389681,-5.90305830245508,-0.1902075430445,"PRKAG2","protein kinase AMP-activated non-catalytic subunit gamma 2",TRUE
+"229157_at",0.384135218769668,0.012446452911025,-2.72034284365023,-2.86283570892598,-2.37053371852481,"PRKAG2-AS1","PRKAG2 antisense RNA 1",TRUE
+"229156_s_at",0.634436854033173,0.105501598113756,-1.68767863695647,-4.64014789291891,-1.76843174203778,"PRKAG2-AS1","PRKAG2 antisense RNA 1",TRUE
+"230373_at",0.861405172272497,0.482024531242378,0.715084341896169,-5.6936484533588,0.556535676780141,"PRKAG2-AS1","PRKAG2 antisense RNA 1",TRUE
+"223904_at",0.903458828743485,0.604560998923212,-0.525345656883521,-5.80614656233735,-0.142527064373877,"PRKAG3","protein kinase AMP-activated non-catalytic subunit gamma 3",TRUE
+"200603_at",0.837368340567858,0.420895697296035,-0.820097838768711,-5.61730810714827,-0.214072881686233,"PRKAR1A","protein kinase cAMP-dependent type I regulatory subunit alpha",TRUE
+"200604_s_at",0.899808883319249,0.592307476680529,-0.543359674855251,-5.79689721374193,-0.293807027174221,"PRKAR1A","protein kinase cAMP-dependent type I regulatory subunit alpha",TRUE
+"200605_s_at",0.91671872326659,0.647892175916842,-0.462982396489298,-5.83581604289155,-0.159699984058426,"PRKAR1A","protein kinase cAMP-dependent type I regulatory subunit alpha",TRUE
+"242482_at",0.966483566497994,0.84355852358209,-0.19967168288475,-5.92028350283865,-0.103519059924436,"PRKAR1A","protein kinase cAMP-dependent type I regulatory subunit alpha",TRUE
+"217361_at",0.982909728377256,0.917184396361538,0.105173591692113,-5.93429727527457,0.0690981482894468,"PRKAR1AP1","protein kinase cAMP-dependent type I regulatory subunit alpha pseudogene 1",TRUE
+"212555_at",0.831182446031643,0.405202749327772,0.848556495549045,-5.59493111107985,0.598192843581747,"PRKAR1B","protein kinase cAMP-dependent type I regulatory subunit beta",TRUE
+"212559_at",0.861659105448003,0.482477115413432,0.714337430167272,-5.6941559538925,0.358641330683133,"PRKAR1B","protein kinase cAMP-dependent type I regulatory subunit beta",TRUE
+"225011_at",0.860085676417428,0.479434970397247,-0.719365830131387,-5.69072959374816,-0.276990678515954,"PRKAR2A","protein kinase cAMP-dependent type II regulatory subunit alpha",TRUE
+"225000_at",0.896118635245982,0.578049615310997,-0.56455223095665,-5.78562810734275,-0.242219323409671,"PRKAR2A","protein kinase cAMP-dependent type II regulatory subunit alpha",TRUE
+"204842_x_at",0.945478751548889,0.753464242520017,-0.317997952136402,-5.89055000810761,-0.104512496082219,"PRKAR2A","protein kinase cAMP-dependent type II regulatory subunit alpha",TRUE
+"204843_s_at",0.955396260969248,0.79576074896937,-0.261975138089962,-5.90631103829448,-0.116689732055841,"PRKAR2A","protein kinase cAMP-dependent type II regulatory subunit alpha",TRUE
+"213052_at",0.964685626382167,0.836699711168725,-0.208556637347771,-5.91852042354846,-0.0737876850699664,"PRKAR2A","protein kinase cAMP-dependent type II regulatory subunit alpha",TRUE
+"203680_at",0.898813992560978,0.588710459008757,0.548682132023136,-5.79410637415294,0.613551829214742,"PRKAR2B","protein kinase cAMP-dependent type II regulatory subunit beta",TRUE
+"1560074_at",0.616413638398853,0.0873515597197715,1.78866619202721,-4.49106886963939,1.06350563143589,"PRKCA","protein kinase C alpha",TRUE
+"206923_at",0.61760967235709,0.0880457501362341,1.78448625814296,-4.49736579373655,2.09841626088448,"PRKCA","protein kinase C alpha",TRUE
+"215195_at",0.725181883744124,0.203637827501679,1.3099337031649,-5.13678642775643,1.43771076922158,"PRKCA","protein kinase C alpha",TRUE
+"213093_at",0.905248825807952,0.610933267919298,0.516047187730966,-5.81080207926946,0.586228331224854,"PRKCA","protein kinase C alpha",TRUE
+"215194_at",0.908882763411412,0.621464010430313,0.50078054461554,-5.81826989692805,0.395902936660459,"PRKCA","protein kinase C alpha",TRUE
+"1555939_at",0.758966211371161,0.256482492845554,-1.16481432609224,-5.29960110881481,-1.31918378288324,"PRKCA-AS1","PRKCA antisense RNA 1",TRUE
+"1555940_a_at",0.931528703027792,0.69726916991856,-0.3941074830451,-5.86431434211382,-0.303816830555265,"PRKCA-AS1","PRKCA antisense RNA 1",TRUE
+"228795_at",0.21219412234776,0.00249609604421663,3.40938008366656,-1.46205844170953,1.40650380144428,"PRKCB","protein kinase C beta",TRUE
+"230437_s_at",0.687734660055697,0.156883135125961,1.46531270029077,-4.94473066499466,0.410584191207428,"PRKCB","protein kinase C beta",TRUE
+"227817_at",0.806325320300355,0.34721761940835,0.960401189918575,-5.50014722582548,0.67502416641826,"PRKCB","protein kinase C beta",TRUE
+"209685_s_at",0.863408882018863,0.48775727070258,0.705653293034158,-5.7000194454906,0.222824045212334,"PRKCB","protein kinase C beta",TRUE
+"207957_s_at",0.875938621758472,0.524409673635484,-0.64679408528253,-5.7379528979013,-0.566351208435838,"PRKCB","protein kinase C beta",TRUE
+"227824_at",0.976094963029937,0.885135587874244,-0.146135819143172,-5.92928726738646,-0.0713836524761007,"PRKCB","protein kinase C beta",TRUE
+"202545_at",0.985498770484702,0.930253160397174,-0.0885269541567986,-5.93586707723316,-0.0717444498413418,"PRKCD","protein kinase C delta",TRUE
+"213010_at",0.396220771188728,0.0136675331405934,2.67871060778282,-2.94341751176733,4.02414743667828,"PRKCDBP","protein kinase C delta binding protein",TRUE
+"236459_at",0.865345395265289,0.494707892033547,-0.694303991134466,-5.70757936775277,-0.779654580816893,"PRKCE","protein kinase C epsilon",TRUE
+"226101_at",0.908801761853008,0.621096589382206,0.501311156188064,-5.81801401349733,0.290088516377264,"PRKCE","protein kinase C epsilon",TRUE
+"234089_at",0.954054753819891,0.789198212016532,0.270606889686299,-5.90407958301124,0.146553942497231,"PRKCE","protein kinase C epsilon",TRUE
+"206248_at",0.968317867540591,0.851285248082764,-0.189682050576206,-5.92217447829911,-0.101410431069817,"PRKCE","protein kinase C epsilon",TRUE
+"236195_x_at",0.814709480171015,0.365573564297865,0.923738707065806,-5.53240817960518,0.410308519624791,"PRKCG","protein kinase C gamma",TRUE
+"206270_at",0.866149078475018,0.496940657387889,-0.690677622035096,-5.70997028114575,-0.290623525432394,"PRKCG","protein kinase C gamma",TRUE
+"230124_at",0.861656789622847,0.482296970636084,-0.714634679103362,-5.69395404405537,-0.285828529679732,"PRKCH","protein kinase C eta",TRUE
+"218764_at",0.937462538530338,0.722380477554303,0.359831178120215,-5.87681530586842,0.25755836689433,"PRKCH","protein kinase C eta",TRUE
+"206099_at",0.954672574687803,0.793522036557629,0.264917414128911,-5.90555848022743,0.172331546806733,"PRKCH","protein kinase C eta",TRUE
+"213518_at",0.321503515621139,0.00713542192235573,2.96380933318578,-2.38097161713043,0.767852498817874,"PRKCI","protein kinase C iota",TRUE
+"209678_s_at",0.527546822913581,0.0399245033916609,2.18283637178504,-3.85234267210284,0.723809568610987,"PRKCI","protein kinase C iota",TRUE
+"209677_at",0.55143263563522,0.0493288892709988,2.07968690043152,-4.02760423674712,0.848990592266166,"PRKCI","protein kinase C iota",TRUE
+"210038_at",0.908801761853008,0.621288955839915,0.501033331741944,-5.81814802523017,0.310446159064632,"PRKCQ","protein kinase C theta",TRUE
+"210039_s_at",0.95442332217412,0.79048184556534,0.268916885126245,-5.90452213342927,0.0881889174735688,"PRKCQ","protein kinase C theta",TRUE
+"232001_at",0.76469251347209,0.264743742923449,1.14421978505439,-5.32135935081343,1.24632530061699,"PRKCQ-AS1","PRKCQ antisense RNA 1",TRUE
+"1561004_at",0.766550448794594,0.267690458759522,-1.13698863758093,-5.32891807242753,-1.07100439203136,"PRKCQ-AS1","PRKCQ antisense RNA 1",TRUE
+"240015_at",0.833105361660875,0.410253240924221,0.839322519391767,-5.60226993896801,0.313714568673716,"PRKCQ-AS1","PRKCQ antisense RNA 1",TRUE
+"200707_at",0.796466121438385,0.329222492253068,0.997645954121462,-5.46620031366474,0.454320194535248,"PRKCSH","protein kinase C substrate 80K-H",TRUE
+"214080_x_at",0.847717593536494,0.446748720122098,0.774626264937454,-5.65157448983577,0.232686040226282,"PRKCSH","protein kinase C substrate 80K-H",TRUE
+"202178_at",0.774230543658252,0.289228677551364,1.08582641365319,-5.38118455718218,0.479830979050506,"PRKCZ","protein kinase C zeta",TRUE
+"217705_at",0.64513208805899,0.115793584503518,1.63682420707928,-4.71274637429313,1.6472947920287,"PRKD1","protein kinase D1",TRUE
+"205880_at",0.782471668844017,0.304846255409872,-1.0504231231495,-5.41609477481512,-0.805132733012849,"PRKD1","protein kinase D1",TRUE
+"241669_x_at",0.369623435296638,0.0110869483063597,2.7715063710771,-2.76303657586227,0.734779036562546,"PRKD2","protein kinase D2",TRUE
+"38269_at",0.90889959300679,0.621609190330186,0.500570923042568,-5.81837091246492,0.161112813405866,"PRKD2","protein kinase D2",TRUE
+"209282_at",0.914242258486146,0.63955990676869,0.474823079701234,-5.83046432815132,0.153963732036788,"PRKD2","protein kinase D2",TRUE
+"1554910_at",0.255716413540338,0.00367428384325488,3.24705928378569,-1.8013473662139,2.60386447671401,"PRKD3","protein kinase D3",TRUE
+"211084_x_at",0.384135218769668,0.0124419900306182,2.72050196696673,-2.86252662268523,1.73168374266137,"PRKD3","protein kinase D3",TRUE
+"242549_at",0.485571841560871,0.0281557830533052,2.3488174478343,-3.55957736413918,3.47039198365422,"PRKD3","protein kinase D3",TRUE
+"222565_s_at",0.556381379241158,0.0518302740443439,2.05524514373783,-4.06833464475468,2.76343292117729,"PRKD3","protein kinase D3",TRUE
+"218236_s_at",0.643082025527735,0.113441194847183,1.64810136760359,-4.69679365595084,2.23467683272438,"PRKD3","protein kinase D3",TRUE
+"215757_at",0.768852835478002,0.273697214426706,1.12242726713855,-5.34401070193075,0.660827787151349,"PRKDC","protein kinase, DNA-activated, catalytic polypeptide",TRUE
+"208694_at",0.895213601869362,0.573355355418535,0.57158675500025,-5.78179507925859,0.188096064563494,"PRKDC","protein kinase, DNA-activated, catalytic polypeptide",TRUE
+"210543_s_at",0.943988850936011,0.749824639518585,0.322864951029882,-5.88903830362854,0.11197440702799,"PRKDC","protein kinase, DNA-activated, catalytic polypeptide",TRUE
+"211380_s_at",0.623667408398064,0.0953111610830633,1.74235946062311,-4.56022436973696,0.76046583493663,"PRKG1","protein kinase, cGMP-dependent, type I",TRUE
+"228396_at",0.731314021977412,0.214441526588203,-1.27810183357301,-5.17390135767086,-0.887010266550699,"PRKG1","protein kinase, cGMP-dependent, type I",TRUE
+"207119_at",0.947778780715578,0.761433200007606,0.307368717986895,-5.89377240485858,0.312031532945303,"PRKG1","protein kinase, cGMP-dependent, type I",TRUE
+"1561558_at",0.921695643419124,0.665778650959211,0.437787154313698,-5.84676282070134,0.303419294930961,"PRKG1-AS1","PRKG1 antisense RNA 1",TRUE
+"207505_at",0.966051687342135,0.841499926844611,0.202336643915211,-5.91976270866001,0.113085349012437,"PRKG2","protein kinase, cGMP-dependent, type II",TRUE
+"237107_at",0.778007390824139,0.29730058880917,1.06736227351078,-5.3995207765788,0.62628299101414,"PRKRA","protein activator of interferon induced protein kinase EIF2AK2",TRUE
+"209139_s_at",0.875938621758472,0.524204096682598,0.647117705974533,-5.73775298459383,0.23676650500825,"PRKRA","protein activator of interferon induced protein kinase EIF2AK2",TRUE
+"204061_at",0.954096423385239,0.789394533949215,0.270348364383299,-5.90414745969818,0.171731603676957,"PRKX","protein kinase, X-linked",TRUE
+"235987_at",0.73223722457785,0.216354963903511,-1.27259394292996,-5.18024448181447,-1.00697222503044,"PRKXP1","protein kinase, X-linked, pseudogene 1",TRUE
+"1559186_at",0.768852835478002,0.27275163794026,1.12470388140319,-5.34166236585616,0.692166229625435,"PRKXP1","protein kinase, X-linked, pseudogene 1",TRUE
+"1559188_x_at",0.932625096890813,0.702449640879023,0.386998186858795,-5.86699930818156,0.282270810921387,"PRKXP1","protein kinase, X-linked, pseudogene 1",TRUE
+"206279_at",0.97763916244156,0.892206565122825,-0.137078737067671,-5.93053542412664,-0.0830795712554826,"PRKY","protein kinase, Y-linked, pseudogene",TRUE
+"204060_s_at",0.849144743801275,0.449926139874971,0.769150242291142,-5.65557686562615,0.534315946877548,"PRKY///PRKX","protein kinase, Y-linked, pseudogene///protein kinase, X-linked",TRUE
+"205445_at",0.705559553212919,0.177359485386523,1.39326976353844,-5.03599283970257,0.482099666880411,"PRL","prolactin",TRUE
+"221443_x_at",0.995449549647697,0.978743450212547,-0.026946738784488,-5.93932981737909,-0.00996617010312928,"PRLH","prolactin releasing hormone",TRUE
+"231805_at",0.971880509429344,0.865452769162846,0.17141573197409,-5.92538205815817,0.127471270898211,"PRLHR","prolactin releasing hormone receptor",TRUE
+"211917_s_at",0.580319028296073,0.0628484710588417,-1.95873637656911,-4.22603068262749,-2.02190618859483,"PRLR","prolactin receptor",TRUE
+"206346_at",0.585892284764425,0.0659220742385058,-1.93450048093812,-4.26482521904546,-2.77454669770132,"PRLR","prolactin receptor",TRUE
+"210476_s_at",0.643515428391208,0.114001441737882,-1.64539787399706,-4.70062567679279,-1.96732241780356,"PRLR","prolactin receptor",TRUE
+"227629_at",0.697871681043328,0.16882538975166,-1.42243920282815,-4.99949590506443,-2.1895962992626,"PRLR","prolactin receptor",TRUE
+"231981_at",0.740610299769501,0.23008489104851,-1.23412997918417,-5.22388635396219,-1.45647819079959,"PRLR","prolactin receptor",TRUE
+"243755_at",0.842038788192302,0.435134741494479,-0.794846771024022,-5.63656368254893,-1.10776251428118,"PRLR","prolactin receptor",TRUE
+"216638_s_at",0.854184492233394,0.464312639348538,-0.744643702063053,-5.67315943318009,-0.929734310094849,"PRLR","prolactin receptor",TRUE
+"206358_at",0.862800800218883,0.486653762863587,0.707463692356342,-5.69880270833993,0.437215296855173,"PRM1","protamine 1",TRUE
+"210122_at",0.906476756086155,0.613834621206513,0.511828774868504,-5.81288741861174,0.187702349094754,"PRM2","protamine 2",TRUE
+"231758_at",0.943631120237335,0.747895072890149,0.32544845506902,-5.88822662387921,0.234376048318792,"PRM3","protamine 3",TRUE
+"1565016_at",0.656693876264681,0.124837127253118,1.59518413028071,-4.77091781992091,0.721768616597189,"PRMT1","protein arginine methyltransferase 1",TRUE
+"206445_s_at",0.946257232656659,0.756463736590278,0.313992815807962,-5.89177695973603,0.122130906106621,"PRMT1","protein arginine methyltransferase 1",TRUE
+"221564_at",0.685360765794715,0.154017071007704,1.47599304595437,-4.93088257521543,0.446167856602443,"PRMT2","protein arginine methyltransferase 2",TRUE
+"216072_at",0.687217870448485,0.155824357780009,1.46923964262647,-4.93964846782721,0.947588682110211,"PRMT2","protein arginine methyltransferase 2",TRUE
+"228722_at",0.77340139236553,0.284789944810155,1.09613820661752,-5.3708221727048,0.382729630695435,"PRMT2","protein arginine methyltransferase 2",TRUE
+"210384_at",0.797508506396963,0.330986998850492,-0.993932893513348,-5.46963733627932,-0.634263939550199,"PRMT2","protein arginine methyltransferase 2",TRUE
+"228725_x_at",0.897949253801113,0.586141371708064,0.552493401402528,-5.79209169360852,0.219836418800165,"PRMT2","protein arginine methyltransferase 2",TRUE
+"216069_at",0.958513463150671,0.811974136375818,0.240734958883665,-5.91149590929991,0.106161645783882,"PRMT2","protein arginine methyltransferase 2",TRUE
+"202098_s_at",0.979347742195592,0.900456184166426,0.126526720884506,-5.93188908854782,0.0490208317857466,"PRMT2","protein arginine methyltransferase 2",TRUE
+"213320_at",0.920835753388243,0.663412020760803,0.441104002596981,-5.8453560606436,0.202495380514723,"PRMT3","protein arginine methyltransferase 3",TRUE
+"217786_at",0.813065886130395,0.362809586961446,-0.929178843000412,-5.52769403233584,-0.358195296592193,"PRMT5","protein arginine methyltransferase 5",TRUE
+"1564520_s_at",0.86481525165637,0.492457097817387,-0.697969119493847,-5.70515075872771,-0.256744358892243,"PRMT5","protein arginine methyltransferase 5",TRUE
+"1564521_x_at",0.895074436729189,0.572585706429631,-0.572742878310115,-5.78116072048905,-0.224899759773495,"PRMT5","protein arginine methyltransferase 5",TRUE
+"1556899_at",0.603702127972549,0.0780646118827286,1.84754091397721,-4.40124757215486,0.517685819601923,"PRMT5-AS1","PRMT5 antisense RNA 1",TRUE
+"223275_at",0.684622294983819,0.15325212524483,-1.47887086086423,-4.92713731502254,-1.08221806542065,"PRMT6","protein arginine methyltransferase 6",TRUE
+"219408_at",0.580137756009815,0.0626612051385782,-1.96024656436512,-4.22360239522908,-0.876746066684898,"PRMT7","protein arginine methyltransferase 7",TRUE
+"230839_at",0.790240875783718,0.319572711759528,1.01820031369978,-5.44696390016753,0.463841294116575,"PRMT8","protein arginine methyltransferase 8",TRUE
+"207772_s_at",0.986421906591669,0.93646877939275,-0.08061894671989,-5.93651835128574,-0.0432513074301273,"PRMT8","protein arginine methyltransferase 8",TRUE
+"228536_at",0.821896104057596,0.384866819813525,-0.886504881056454,-5.56398696545388,-0.307092826968653,"PRMT9","protein arginine methyltransferase 9",TRUE
+"222106_at",0.676294804179428,0.143032219550868,1.51848872966697,-4.87498248144728,0.666374793916138,"PRND","prion protein 2 (dublet)",TRUE
+"223813_at",0.863559206655094,0.488511471129142,0.704417321467169,-5.70084841336654,0.290874023243125,"PRND","prion protein 2 (dublet)",TRUE
+"215707_s_at",0.59507179340408,0.0719972971984213,1.88938589838702,-4.33614971783893,1.73735297275925,"PRNP","prion protein",TRUE
+"201300_s_at",0.734730148360473,0.219374894906559,1.26397670817355,-5.19012150108587,1.59822320183332,"PRNP","prion protein",TRUE
+"233975_at",0.870525641150512,0.509691922721206,-0.670142363711069,-5.72328362112359,-0.175904530305223,"PRNT","prion protein (testis specific)",TRUE
+"224231_at",0.403515103228677,0.0149745248184908,2.63787000374085,-3.02190007887202,2.31820849559994,"PRO0471","uncharacterized LOC28994",TRUE
+"223890_at",0.627092759817312,0.0986118189035489,-1.72412458783532,-4.58708858204747,-1.75619882608327,"PRO1082","uncharacterized protein PRO1082",TRUE
+"220568_at",0.955396260969248,0.795669535942533,0.262094970432856,-5.90628055137783,0.173808766088355,"PRO1483","uncharacterized LOC55448",TRUE
+"221243_s_at",0.740476003158683,0.229627196130771,1.23538358035345,-5.2224821515421,0.793121154965324,"PRO1596","uncharacterized LOC29013",TRUE
+"224083_s_at",0.934545953720034,0.709571214938816,0.377258015371506,-5.87059964519504,0.316222023167133,"PRO1596","uncharacterized LOC29013",TRUE
+"224110_at",0.778868437679472,0.299809147497068,-1.06169721691253,-5.405090168885,-0.989554191902231,"PRO1804","uncharacterized LOC100133319",TRUE
+"220883_at",0.861659105448003,0.482669121086485,-0.714020681062869,-5.69437102145093,-0.556514358967958,"PRO2012","uncharacterized protein PRO2012",TRUE
+"222965_at",0.673322568613087,0.138979658441491,1.53484254413689,-4.85313270971976,0.832006975211353,"PRO2214","uncharacterized protein PRO2214",TRUE
+"220699_s_at",0.954577684533304,0.792846938672835,-0.265805143968693,-5.90532978251929,-0.197183700540094,"PRO2214","uncharacterized protein PRO2214",TRUE
+"207751_at",0.789661545166663,0.317182044282889,1.02335928429148,-5.44208000250649,0.507357984372652,"PRO2949","uncharacterized protein PRO2949",TRUE
+"1553374_at",0.935094665155941,0.711378226578462,0.374792504793493,-5.87149663641041,0.37070534755067,"PRO2949","uncharacterized protein PRO2949",TRUE
+"207478_at",0.633098477100746,0.10438505764724,1.69344494244542,-4.63180984246536,1.0027543045513,"PRO2958","uncharacterized LOC100128329",TRUE
+"207477_at",0.835952408568777,0.416745401868812,-0.827558091625276,-5.61151116638194,-0.642292111059296,"PRO2958","uncharacterized LOC100128329",TRUE
+"220872_at",0.974292018919448,0.874551123326185,0.159716936546516,-5.92726637635308,0.105442777761995,"PRO2964","uncharacterized protein PRO2964",TRUE
+"206259_at",0.186027202406852,0.00183050086684749,3.53850113579237,-1.18929501917266,2.17550985812547,"PROC","protein C, inactivator of coagulation factors Va and VIIIa",TRUE
+"236286_at",0.726636642789909,0.206091483042636,1.3025914396681,-5.14541599305891,0.814124509898149,"PROCA1","protein interacting with cyclin A1",TRUE
+"232647_at",0.945432830098469,0.753258887499636,0.318272350114015,-5.89046538406601,0.210993529862209,"PROCA1","protein interacting with cyclin A1",TRUE
+"203650_at",0.863318594825537,0.487513417919793,0.706053150816129,-5.69975096380937,0.978608290010528,"PROCR","protein C receptor",TRUE
+"243614_s_at",0.62110896023334,0.0917085521085639,1.76289002854324,-4.52972801580037,1.08491313508944,"PRODH2","proline dehydrogenase 2",TRUE
+"216696_s_at",0.782471668844017,0.304815599146365,1.05049133647197,-5.41602850918395,0.396993827992845,"PRODH2","proline dehydrogenase 2",TRUE
+"229124_at",0.433660982257499,0.019515905101528,2.51812492678015,-3.2485861041253,1.08969369837516,"PROK1","prokineticin 1",TRUE
+"232629_at",0.953564723226096,0.786285398732649,-0.274444834349849,-5.90306434147238,-0.211793356558529,"PROK2","prokineticin 2",TRUE
+"234450_at",0.812302873476553,0.359127398933749,0.936469494813736,-5.52133641562975,0.309549849593135,"PROKR2","prokineticin receptor 2",TRUE
+"204304_s_at",0.417001048339868,0.0169945821211499,2.58091198603389,-3.13037992455443,2.66402307905979,"PROM1","prominin 1",TRUE
+"1562378_s_at",0.723973974120865,0.200991051057147,1.31793142882111,-5.12733982210182,0.48585778671548,"PROM2","prominin 2",TRUE
+"1552797_s_at",0.78187900363728,0.303441377335447,1.05355413398136,-5.41304918124534,1.09266566599105,"PROM2","prominin 2",TRUE
+"239528_at",0.795265846168267,0.327349365722002,1.00160269717181,-5.46252492055828,0.398603378634812,"PROM2","prominin 2",TRUE
+"234647_at",0.839519981963042,0.427639843334106,0.808072790671181,-5.62654848845753,0.503095867785258,"PROM2","prominin 2",TRUE
+"234198_at",0.90105641459739,0.59741199077953,-0.535833707040758,-5.8007983319283,-0.230072273608386,"PROM2","prominin 2",TRUE
+"211223_at",0.729083413548563,0.211014278463594,1.28806271256348,-5.16237071023466,0.956078359302261,"PROP1","PROP paired-like homeobox 1",TRUE
+"237291_at",0.774230543658252,0.289142463782,1.08602560988408,-5.38098521047877,1.24490493240169,"PRORSD1P","prolyl-tRNA synthetase associated domain containing 1, pseudogene",TRUE
+"221179_at",0.345823377376834,0.00882788745811933,2.87142216985565,-2.56583348738595,1.15740849673112,"PRORY","proline rich, Y-linked",TRUE
+"207808_s_at",0.943464796017993,0.746524768978893,0.327284532106986,-5.88764587673233,0.422620908224158,"PROS1","protein S (alpha)",TRUE
+"214545_s_at",0.731360797779119,0.214478994633569,-1.2779936179892,-5.1740262084477,-0.791638576479702,"PROSC","proline synthetase cotranscribed homolog (bacterial)",TRUE
+"227315_x_at",0.807944276806637,0.349509549135341,0.955753059772499,-5.50430101089425,0.580402005493103,"PROSC","proline synthetase cotranscribed homolog (bacterial)",TRUE
+"209385_s_at",0.819780516863333,0.377440414852157,-0.900687926783338,-5.55209956386456,-0.551012342848219,"PROSC","proline synthetase cotranscribed homolog (bacterial)",TRUE
+"209384_at",0.820291269575398,0.378981649110008,-0.897729487449825,-5.55459356378456,-0.549964744216066,"PROSC","proline synthetase cotranscribed homolog (bacterial)",TRUE
+"216519_s_at",0.94118897722809,0.736862563620409,0.340264014227408,-5.8834483052927,0.206790723389003,"PROSC","proline synthetase cotranscribed homolog (bacterial)",TRUE
+"225887_at",0.939976205834042,0.730086305833852,-0.34940228374156,-5.88039616174203,-0.116179159224133,"PROSER1","proline and serine rich 1",TRUE
+"218420_s_at",0.955892698633978,0.79923486365575,0.257413871971514,-5.90746118598116,0.0808681735947037,"PROSER1","proline and serine rich 1",TRUE
+"229801_at",0.369623435296638,0.0110968193909661,2.77111390400847,-2.7638052587571,2.58582931291828,"PROSER2","proline and serine rich 2",TRUE
+"230051_at",0.497885178357455,0.0309529026566348,2.30429058009411,-3.63935314926507,2.58039023808921,"PROSER2","proline and serine rich 2",TRUE
+"1569722_s_at",0.697172073261335,0.167490286256016,-1.42710874893266,-4.99359566209905,-0.824042060579277,"PROSER2-AS1","PROSER2 antisense RNA 1",TRUE
+"1557208_at",0.920147736488699,0.660063725043234,-0.445805275626343,-5.84334428077927,-0.27486133684312,"PROSER2-AS1","PROSER2 antisense RNA 1",TRUE
+"242640_at",0.942502815705589,0.741618268630239,-0.333868248493997,-5.88553688085036,-0.10100545892263,"PROSER3","proline and serine rich 3",TRUE
+"1553162_x_at",0.965620759643697,0.839347744519897,0.205124360487153,-5.91921056534742,0.0589034542225413,"PROSER3","proline and serine rich 3",TRUE
+"229376_at",0.610033432202476,0.0825977498550505,1.81808679126602,-4.44644568523956,1.31625498288105,"PROX1","prospero homeobox 1",TRUE
+"228656_at",0.68806049531767,0.157482442352416,-1.46309941376935,-4.94759021519803,-0.532034943643864,"PROX1","prospero homeobox 1",TRUE
+"207401_at",0.772202741217767,0.282569003082649,1.10134140021922,-5.36556036933804,0.693558635499658,"PROX1","prospero homeobox 1",TRUE
+"242119_at",0.822850703882235,0.388346217441567,-0.879921459721416,-5.56944539433206,-0.412590262912104,"PROX1","prospero homeobox 1",TRUE
+"1559483_at",0.989586772349659,0.949617693373237,-0.0639065550862393,-5.93769448740978,-0.0227027386769449,"PROX1-AS1","PROX1 antisense RNA 1",TRUE
+"234804_at",0.943824539742785,0.74837282899867,0.324808575811254,-5.8884282563797,0.256157214342839,"PROX2","prospero homeobox 2",TRUE
+"208034_s_at",0.662855903464759,0.130613551077046,1.56988632347844,-4.80568897446124,0.962406725933691,"PROZ","protein Z, vitamin K dependent plasma glycoprotein",TRUE
+"221546_at",0.700890836612645,0.1725784507281,1.40946946700981,-5.01580058451849,1.14991055532096,"PRPF18","pre-mRNA processing factor 18",TRUE
+"221547_at",0.90344422113846,0.604069066172013,0.526065432309735,-5.8057828119933,0.156580450104595,"PRPF18","pre-mRNA processing factor 18",TRUE
+"203103_s_at",0.744307803443383,0.235152540568948,-1.22037489478492,-5.23921305467939,-0.502118365451498,"PRPF19","pre-mRNA processing factor 19",TRUE
+"202251_at",0.695812999227098,0.165938068736717,-1.4325753708194,-4.98666814702009,-0.524779913530395,"PRPF3","pre-mRNA processing factor 3",TRUE
+"202408_s_at",0.672434875127089,0.138434398826659,-1.53707272166021,-4.85013864195119,-0.484786346150885,"PRPF31","pre-mRNA processing factor 31",TRUE
+"202407_s_at",0.71454754703986,0.189599000797244,-1.35332473084615,-5.08495430801076,-0.443977161974082,"PRPF31","pre-mRNA processing factor 31",TRUE
+"214380_at",0.745510155593313,0.23715881364855,-1.21499127737456,-5.24517134042927,-0.431628382069792,"PRPF31","pre-mRNA processing factor 31",TRUE
+"235612_at",0.752913428584105,0.246246747974531,-1.19102600564868,-5.27141725327766,-0.464854453842766,"PRPF38A","pre-mRNA processing factor 38A",TRUE
+"1553709_a_at",0.801892820429336,0.339494706000799,-0.976219206954899,-5.48587362034156,-0.31538891490421,"PRPF38A","pre-mRNA processing factor 38A",TRUE
+"223230_at",0.94630837494651,0.756833042762966,-0.313500055617937,-5.89192684999771,-0.109384438127908,"PRPF38A","pre-mRNA processing factor 38A",TRUE
+"218040_at",0.725181883744124,0.203731327509581,-1.30965265894025,-5.13711750230875,-0.502068188786907,"PRPF38B","pre-mRNA processing factor 38B",TRUE
+"230270_at",0.977369242833284,0.891677299259541,-0.137756247769602,-5.93044481367314,-0.0700715139372061,"PRPF38B","pre-mRNA processing factor 38B",TRUE
+"220553_s_at",0.625075149000452,0.0963651919960009,-1.73647846880703,-4.56891136745123,-0.408737412304706,"PRPF39","pre-mRNA processing factor 39",TRUE
+"209162_s_at",0.950915298281049,0.775776440417489,0.28832704825275,-5.89927362978912,0.0969075111447903,"PRPF4","pre-mRNA processing factor 4",TRUE
+"209161_at",0.997171203405,0.985595780983699,-0.0182588510747348,-5.93952110219896,-0.00691436016268554,"PRPF4","pre-mRNA processing factor 4",TRUE
+"213729_at",0.729273475042162,0.211682105767628,-1.28611200742305,-5.16463483414381,-0.336711718045093,"PRPF40A","pre-mRNA processing factor 40 homolog A",TRUE
+"218053_at",0.857316604145187,0.472586713068522,-0.73075403506086,-5.68288518578653,-0.176392623127708,"PRPF40A","pre-mRNA processing factor 40 homolog A",TRUE
+"214941_s_at",0.869487815945782,0.506815924907329,-0.674748491502365,-5.72033083188767,-0.198422574370118,"PRPF40A","pre-mRNA processing factor 40 homolog A",TRUE
+"236477_at",0.8920930097751,0.562870670597049,-0.58740497342384,-5.77300805122074,-0.20679328276811,"PRPF40A","pre-mRNA processing factor 40 homolog A",TRUE
+"226687_at",0.906476756086155,0.614040480813948,0.511529824007915,-5.81303456941655,0.288756240307621,"PRPF40A","pre-mRNA processing factor 40 homolog A",TRUE
+"233080_s_at",0.908667507590078,0.620213598147788,-0.502586926171477,-5.81739770065581,-0.138049655687388,"PRPF40A","pre-mRNA processing factor 40 homolog A",TRUE
+"226966_at",0.989654520357877,0.950206303537703,-0.0631588983536199,-5.93774075005982,-0.0543661931139727,"PRPF40B","pre-mRNA processing factor 40 homolog B",TRUE
+"202127_at",0.895457620469779,0.574058497827002,0.570531221542028,-5.78237316029104,0.200214253877958,"PRPF4B","pre-mRNA processing factor 4B",TRUE
+"237093_at",0.95018792835023,0.773715119404928,-0.291056742833724,-5.89850642369615,-0.173864188190519,"PRPF4B","pre-mRNA processing factor 4B",TRUE
+"211090_s_at",0.95643295620889,0.802684547178814,0.252890197602623,-5.90858202858196,0.0836583011960776,"PRPF4B","pre-mRNA processing factor 4B",TRUE
+"202126_at",0.987618239812333,0.941502293470479,-0.0742187896035813,-5.93700088431178,-0.0211890775894776,"PRPF4B","pre-mRNA processing factor 4B",TRUE
+"208880_s_at",0.635368778245437,0.106292119301775,-1.68362724206063,-4.64599334817716,-0.636916915458265,"PRPF6","pre-mRNA processing factor 6",TRUE
+"208879_x_at",0.718943521687533,0.194939875793647,-1.33652976212126,-5.10518487784093,-0.536511003976537,"PRPF6","pre-mRNA processing factor 6",TRUE
+"200000_s_at",0.96357296999255,0.834036475374504,0.212011205919992,-5.91781428435655,0.0753319162390689,"PRPF8","pre-mRNA processing factor 8",TRUE
+"213847_at",0.55092132555352,0.0492126155281828,-2.08084983326564,-4.02565850658963,-0.79312014844322,"PRPH","peripherin",TRUE
+"206625_at",0.747104241359439,0.238991370486998,1.21010378409691,-5.25056078147024,0.90188257846849,"PRPH2","peripherin 2",TRUE
+"209440_at",0.996296795497044,0.982106240461984,0.0226829235148951,-5.93943288256043,0.0143982318187881,"PRPS1","phosphoribosyl pyrophosphate synthetase 1",TRUE
+"208447_s_at",0.997608949249317,0.98815355960102,0.0150163174936592,-5.93957365358238,0.0105593143997602,"PRPS1","phosphoribosyl pyrophosphate synthetase 1",TRUE
+"215486_at",0.885694554133555,0.54740381236852,-0.611020658927736,-5.75945819191776,-0.238948095405377,"PRPS1L1","phosphoribosyl pyrophosphate synthetase 1-like 1",TRUE
+"230352_at",0.77204612088057,0.282298942816893,1.1019761108923,-5.36491699328462,0.675418606271146,"PRPS2","phosphoribosyl pyrophosphate synthetase 2",TRUE
+"203401_at",0.948703051410075,0.766816797754226,0.300208390052126,-5.89588196184183,0.154891027824732,"PRPS2","phosphoribosyl pyrophosphate synthetase 2",TRUE
+"1556715_at",0.585036027492332,0.0653008755940852,-1.93931721895544,-4.25714141684198,-1.22381160266703,"PRPSAP1","phosphoribosyl pyrophosphate synthetase associated protein 1",TRUE
+"202529_at",0.899998627338565,0.594422951546899,-0.540236843714806,-5.79852236801165,-0.140749300849331,"PRPSAP1","phosphoribosyl pyrophosphate synthetase associated protein 1",TRUE
+"203537_at",0.594005743610726,0.0708952072857356,1.89731551738913,-4.32369819062632,0.757731819839714,"PRPSAP2","phosphoribosyl pyrophosphate synthetase associated protein 2",TRUE
+"228273_at",0.773234064853267,0.284460082967209,1.09690914183899,-5.37004395216429,0.669955190815548,"PRR11","proline rich 11",TRUE
+"219392_x_at",0.813065886130395,0.362881506719714,0.929036938121648,-5.52781732340989,0.451899561753219,"PRR11","proline rich 11",TRUE
+"232215_x_at",0.909441642299191,0.624009639929748,0.49710825888086,-5.82003357801015,0.158072476490025,"PRR11","proline rich 11",TRUE
+"226716_at",0.921797789017863,0.666660784501968,0.436552115788236,-5.84728396896026,0.162472225470601,"PRR12","proline rich 12",TRUE
+"217794_at",0.635174103121116,0.106054035434708,-1.6848447194533,-4.64423785649761,-0.569512738330548,"PRR13","proline rich 13",TRUE
+"218714_at",0.182644973816866,0.00172498803738932,-3.56312511208632,-1.13703248999133,-1.30035185319021,"PRR14","proline rich 14",TRUE
+"45687_at",0.434966352619557,0.0197773452695422,-2.51205486775419,-3.25993484839937,-0.790158714755389,"PRR14","proline rich 14",TRUE
+"1559397_s_at",0.517348414110187,0.0365335361897142,-2.22550312311667,-3.77831036450186,-0.921029109450515,"PRR14","proline rich 14",TRUE
+"1558097_at",0.52645337190204,0.0397426591200059,-2.18503936286784,-3.84854172564476,-0.809227613633254,"PRR14L","proline rich 14 like",TRUE
+"1553761_at",0.610076166481657,0.0826713181063117,-1.81762045837704,-4.44715708979915,-0.786899060668999,"PRR14L","proline rich 14 like",TRUE
+"236941_at",0.885365229653684,0.546926577623286,0.611754859738076,-5.75902867157123,0.202094063175194,"PRR14L","proline rich 14 like",TRUE
+"216555_at",0.886782011834068,0.549907697929097,0.607174090021868,-5.76170036905233,0.285324467721025,"PRR14L","proline rich 14 like",TRUE
+"226961_at",0.929799592139474,0.690270972929881,0.403744306417195,-5.86059795585946,0.533117074525855,"PRR15","proline rich 15",TRUE
+"219127_at",0.587626678796111,0.0665344218545297,-1.92979132885733,-4.27232467712664,-2.09648781342899,"PRR15L","proline rich 15 like",TRUE
+"220014_at",0.983567332578112,0.919813109057405,0.101822916780346,-5.93463491717356,0.181295964400479,"PRR16","proline rich 16",TRUE
+"1554867_a_at",0.990390614845554,0.951771267962139,-0.0611712478806542,-5.93786109305287,-0.0808046153159436,"PRR16","proline rich 16",TRUE
+"238008_at",0.62110896023334,0.0914394063601802,1.76445145446582,-4.52739789096914,1.15516731944998,"PRR18","proline rich 18",TRUE
+"231176_at",0.844974084282113,0.442029241127334,-0.782803827090663,-5.64554772348526,-0.563668425983202,"PRR19","proline rich 19",TRUE
+"1562722_at",0.725583196024696,0.204373034647911,1.30772650449977,-5.13938492531175,0.462327471542734,"PRR20E///PRR20D///PRR20C///PRR20B///PRR20A","proline rich 20E///proline rich 20D///proline rich 20C///proline rich 20B///proline rich 20A",TRUE
+"1552272_a_at",0.355028107426795,0.00955183074576709,-2.83698484868468,-2.63413477549844,-1.2321643454939,"PRR22","proline rich 22",TRUE
+"1552271_at",0.776181137432978,0.293704640366797,-1.07554286805421,-5.39143152874846,-0.463914356617282,"PRR22","proline rich 22",TRUE
+"240731_at",0.873714994839466,0.519500956206417,0.654540541741372,-5.7331412540083,0.32860707600664,"PRR23D2///PRR23D1","proline rich 23 domain containing 2///proline rich 23 domain containing 1",TRUE
+"1557548_at",0.813065886130395,0.362731375869229,-0.929333182677272,-5.52755991788723,-0.790522420653906,"PRR26","proline rich 26",TRUE
+"1559000_at",0.959357995170594,0.816281271865361,-0.235111828279185,-5.91279562055835,-0.0836838904111108,"PRR26","proline rich 26",TRUE
+"232972_at",0.789378278298554,0.315742576426039,1.02647875521015,-5.4391160429043,0.368539671792,"PRR29","proline rich 29",TRUE
+"244204_at",0.680708651141727,0.148467952737112,1.4971394618629,-4.90322512027717,1.23329024602851,"PRR3","proline rich 3",TRUE
+"204795_at",0.856257656023992,0.469770202111455,-0.735465840761688,-5.67960538316603,-0.346199012119017,"PRR3","proline rich 3",TRUE
+"237319_at",0.545992239117952,0.0472294629870788,2.10107400213753,-3.99170891395451,0.779043433041583,"PRR30","proline rich 30",TRUE
+"240043_at",0.846552177460323,0.444853330481489,-0.77790409446925,-5.64916593559564,-0.534681890339977,"PRR32","proline rich 32",TRUE
+"220681_at",0.774230543658252,0.289740742298115,1.08464417216004,-5.38236702057881,0.473064171182718,"PRR34","proline rich 34",TRUE
+"238058_at",0.562980111254122,0.0556029739510244,2.02030434935789,-4.12601160532835,1.05924522520216,"PRR34-AS1","PRR34 antisense RNA 1",TRUE
+"1553826_a_at",0.729747638370823,0.212017215098684,-1.28513495313503,-5.16576777364838,-0.62355187200399,"PRR35","proline rich 35",TRUE
+"220584_at",0.82145314869164,0.383690361431863,0.888739664579334,-5.56212549510226,0.989473701957778,"PRR36","proline rich 36",TRUE
+"219168_s_at",0.956960361976289,0.804753604557203,0.250179571308911,-5.90924418479341,0.141912173314608,"PRR5","proline rich 5",TRUE
+"47069_at",0.988224361618126,0.943867483853565,0.0712125427226316,-5.93721377524429,0.0316316076789924,"PRR5","proline rich 5",TRUE
+"1555162_at",0.585036027492332,0.0654280033009642,1.93832820338032,-4.25872019529738,1.47706661595774,"PRR5-ARHGAP8///ARHGAP8","PRR5-ARHGAP8 readthrough///Rho GTPase activating protein 8",TRUE
+"205980_s_at",0.896229101808264,0.580019373717208,0.561609045738257,-5.7872181572461,0.777157079364246,"PRR5-ARHGAP8///ARHGAP8","PRR5-ARHGAP8 readthrough///Rho GTPase activating protein 8",TRUE
+"37117_at",0.926430328514448,0.680318920422704,0.417516289256094,-5.85513352784262,0.444282994711799,"PRR5-ARHGAP8///ARHGAP8","PRR5-ARHGAP8 readthrough///Rho GTPase activating protein 8",TRUE
+"232567_at",0.990810941805126,0.955578422473359,0.0563368451720855,-5.93813773847103,0.0484317664300598,"PRR5-ARHGAP8///ARHGAP8","PRR5-ARHGAP8 readthrough///Rho GTPase activating protein 8",TRUE
+"1555486_a_at",0.40822709278732,0.0157317692638845,2.61571779501463,-3.06422759456206,1.36961767512735,"PRR5L","proline rich 5 like",TRUE
+"219383_at",0.51470556386048,0.0351284497160574,2.24424682974091,-3.74551324053257,2.75341773312936,"PRR5L","proline rich 5 like",TRUE
+"233379_at",0.526634268561088,0.0397901447357267,2.18446320830146,-3.84953602643702,1.92787082325163,"PRR5L","proline rich 5 like",TRUE
+"233119_at",0.955925931146022,0.800973541837602,0.255133210608095,-5.90802873965548,0.0769657384584881,"PRR5L","proline rich 5 like",TRUE
+"219742_at",0.363091959627129,0.0105457710450458,-2.79354720867418,-2.71979134517934,-1.29194575543794,"PRR7","proline rich 7 (synaptic)",TRUE
+"1560448_at",0.855231830274151,0.467542375983436,0.739204652711781,-5.67698863008497,0.506709361385312,"PRR7-AS1","PRR7 antisense RNA 1",TRUE
+"237732_at",0.823074246722209,0.389885782656149,0.877020686393261,-5.57183849629315,0.536573096762379,"PRR9","proline rich 9",TRUE
+"224643_at",0.695812999227098,0.165910319644191,-1.43267347112564,-4.98654363256336,-0.413403612473278,"PRRC1","proline rich coiled-coil 1",TRUE
+"221734_at",0.838350471423215,0.423359093654128,-0.815691648160098,-5.6207088038176,-0.318354624619559,"PRRC1","proline rich coiled-coil 1",TRUE
+"208132_x_at",0.965992617204023,0.840809915753954,0.203230233897332,-5.91958654107527,0.0577594458300332,"PRRC2A","proline rich coiled-coil 2A",TRUE
+"214201_x_at",0.990345207157428,0.951660974378564,-0.0613113226296138,-5.93785273815974,-0.0199084458295893,"PRRC2A","proline rich coiled-coil 2A",TRUE
+"212081_x_at",0.99783553534859,0.98945826011491,-0.0133623952479013,-5.93959651424464,-0.00363078251546156,"PRRC2A","proline rich coiled-coil 2A",TRUE
+"212069_s_at",0.819479221404744,0.376792274285256,-0.901934425989562,-5.55104647880643,-0.364862517511689,"PRRC2B","proline rich coiled-coil 2B",TRUE
+"212068_s_at",0.861659105448003,0.482729470311074,-0.713921138897699,-5.69443859023302,-0.219896326057722,"PRRC2B","proline rich coiled-coil 2B",TRUE
+"223793_at",0.879447209955825,0.53392160062664,0.631895280083334,-5.74705239804874,0.211928632999876,"PRRC2B","proline rich coiled-coil 2B",TRUE
+"211946_s_at",0.784552021081681,0.307838978450142,-1.0437872795439,-5.42252265308098,-0.261829304890661,"PRRC2C","proline rich coiled-coil 2C",TRUE
+"214052_x_at",0.823073978212882,0.388961825269252,0.878760665624449,-5.57040391509709,0.350989396842587,"PRRC2C","proline rich coiled-coil 2C",TRUE
+"211944_at",0.863045252498003,0.487062173042129,-0.706793384443842,-5.69925355668035,-0.275463289602952,"PRRC2C","proline rich coiled-coil 2C",TRUE
+"214055_x_at",0.937842878751575,0.724950709995176,-0.356348219422314,-5.87802278175639,-0.117114001635345,"PRRC2C","proline rich coiled-coil 2C",TRUE
+"211947_s_at",0.966593471043185,0.844255657268878,0.198769543110612,-5.92045824321134,0.134912057545234,"PRRC2C","proline rich coiled-coil 2C",TRUE
+"211948_x_at",0.979480079564868,0.901157502374971,-0.125630366263248,-5.93199909132864,-0.0389799603719325,"PRRC2C","proline rich coiled-coil 2C",TRUE
+"205618_at",0.74356448121899,0.234336709206848,1.22257402790242,-5.23677262238979,1.36755008137214,"PRRG1","proline rich and Gla domain 1",TRUE
+"205617_at",0.812302873476553,0.360834171837967,-0.933083920582927,-5.52429439406452,-0.452280797627363,"PRRG2","proline rich and Gla domain 2",TRUE
+"220433_at",0.453601396285638,0.0218897813380735,2.46558186113458,-3.34634604164874,0.904966111282057,"PRRG3","proline rich and Gla domain 3",TRUE
+"229118_at",0.756584150514497,0.251881793653706,1.17649744966348,-5.28710663810061,0.416940237361306,"PRRG3","proline rich and Gla domain 3",TRUE
+"207291_at",0.768852835478002,0.272707245978235,1.12481090325847,-5.34155186885661,0.787147816973313,"PRRG4","proline rich and Gla domain 4",TRUE
+"238513_at",0.871451481476429,0.512608273288913,0.665486432723524,-5.72624865205075,0.665113510563344,"PRRG4","proline rich and Gla domain 4",TRUE
+"227192_at",0.7717895132349,0.28182230100322,-1.10309741556095,-5.3637795750754,-0.874840011136231,"PRRT2","proline rich transmembrane protein 2",TRUE
+"1556308_at",0.646392036827936,0.117350804714689,-1.62946444955832,-4.72311214884922,-1.44831484954645,"PRRT3","proline rich transmembrane protein 3",TRUE
+"242888_at",0.632949074657601,0.103697764157228,1.69702050281376,-4.6266288377564,1.06845275729652,"PRRT3-AS1","PRRT3 antisense RNA 1",TRUE
+"205991_s_at",0.862084021761252,0.484832585004787,-0.710456686369301,-5.69678465679599,-0.218964361526779,"PRRX1","paired related homeobox 1",TRUE
+"226695_at",0.905462783815257,0.611541183818979,0.515162527278332,-5.81124078682751,0.425668133232453,"PRRX1","paired related homeobox 1",TRUE
+"238852_at",0.991689960875868,0.96107739233134,0.049356537884975,-5.93849703157775,0.058780452435319,"PRRX1","paired related homeobox 1",TRUE
+"219729_at",0.845487921422997,0.442634250396009,0.781752543369781,-5.64632584947421,0.734976229031727,"PRRX2","paired related homeobox 2",TRUE
+"231602_at",0.97928472590149,0.899100691289596,0.128259477606727,-5.93167422678574,0.0368303486477997,"PRRX2-AS1","PRRX2 antisense RNA 1",TRUE
+"213802_at",0.517348414110187,0.0364982421379943,2.22596584169993,-3.7775027118541,3.04343479866404,"PRSS12","protease, serine 12",TRUE
+"205515_at",0.671498069723584,0.137610052849956,1.54045816778254,-4.84558701209987,1.64089273990369,"PRSS12","protease, serine 12",TRUE
+"208165_s_at",0.597346378847428,0.0733938253158221,1.87948894340231,-4.35163914103601,2.54263551844182,"PRSS16","protease, serine 16",TRUE
+"216470_x_at",0.28785267911226,0.00492237831021611,3.12306933010621,-2.0572466166611,2.02420602822505,"PRSS2","protease, serine 2",TRUE
+"205402_x_at",0.453080088291554,0.021852257756284,2.46637026903707,-3.34488720277111,2.52701656214467,"PRSS2","protease, serine 2",TRUE
+"205869_at",0.908709061737317,0.620822451471755,0.501707147825139,-5.81782287717089,0.438367212448115,"PRSS2///PRSS1","protease, serine 2///protease, serine 1",TRUE
+"220051_at",0.411110107932987,0.0162640210860819,2.60073924058491,-3.09274945540807,2.68256723651664,"PRSS21","protease, serine 21",TRUE
+"205847_at",0.934926171367715,0.710989327025621,0.375322924182594,-5.8713041513869,0.162041210450569,"PRSS22","protease, serine 22",TRUE
+"202458_at",0.840879524142924,0.430326434331502,0.803315443350604,-5.63016879725643,0.903722661041893,"PRSS23","protease, serine 23",TRUE
+"226279_at",0.925269184248693,0.676347658302392,0.423034708572103,-5.85289336135629,0.50278088218149,"PRSS23","protease, serine 23",TRUE
+"1565677_at",0.961561244483099,0.826016435469018,-0.222430399148719,-5.91561458424254,-0.0850947464955247,"PRSS23","protease, serine 23",TRUE
+"229441_at",0.980009054680439,0.905841038364415,0.119647004951493,-5.93271337882764,0.189551439804053,"PRSS23","protease, serine 23",TRUE
+"232074_at",0.939976205834042,0.730047693452192,-0.349454441555863,-5.88037851179067,-0.313138595393807,"PRSS27","protease, serine 27",TRUE
+"207463_x_at",0.110991055948466,0.000546517902493062,4.03572286120805,-0.123620007185949,3.02595744507785,"PRSS3","protease, serine 3",TRUE
+"213421_x_at",0.165626734753013,0.00134617431201752,3.66568388079042,-0.918629662281203,2.74525017907506,"PRSS3","protease, serine 3",TRUE
+"231638_at",0.540483367247649,0.0450267510324277,2.12445192819766,-3.95220356153769,1.63559399550137,"PRSS30P","protease, serine, 30 pseudogene",TRUE
+"1552349_a_at",0.899998627338565,0.594514501774716,0.540101821517795,-5.79859242961476,0.484791690904083,"PRSS33","protease, serine 33",TRUE
+"1552348_at",0.940227139261806,0.732999256650826,0.345470289591698,-5.88171923180709,0.314679803846675,"PRSS33","protease, serine 33",TRUE
+"235874_at",0.673582826047901,0.139867612119752,-1.5312260670784,-4.85798058380128,-1.20400935043276,"PRSS35","protease, serine 35",TRUE
+"1552555_at",0.735706533801341,0.220826336099018,-1.25986745129857,-5.1948112841222,-0.929004423315672,"PRSS36","protease, serine 36",TRUE
+"231572_at",0.784918343662568,0.309742250257294,-1.03959081578403,-5.42656868443524,-0.565092507558644,"PRSS37","protease, serine 37",TRUE
+"215395_x_at",0.331700023364203,0.00808971890877339,2.90942963605481,-2.49006257445619,2.56665238580934,"PRSS3P2","protease, serine 3 pseudogene 2",TRUE
+"220126_at",0.779854829728531,0.301088850638218,1.05882028483487,-5.40790834831514,0.74608243759523,"PRSS50","protease, serine 50",TRUE
+"214226_at",0.778665200947143,0.299033081389645,1.06344617540773,-5.40337357785905,0.69583455073654,"PRSS53","protease, serine 53",TRUE
+"231287_s_at",0.859807554381411,0.478092324106399,0.721591021995998,-5.68920604735968,0.454708113004616,"PRSS54","protease, serine 54",TRUE
+"1570274_at",0.945272089973488,0.752911353006025,-0.318736786922013,-5.89032198755173,-0.119377480750956,"PRSS55","protease, serine 55",TRUE
+"237513_at",0.776983560547865,0.29596028960061,1.07040306373007,-5.3965203921712,0.431585690278543,"PRSS58","protease, serine 58",TRUE
+"202525_at",0.850693751204364,0.453593581166112,-0.762858749496369,-5.66014215119592,-0.76797203849285,"PRSS8","protease, serine 8",TRUE
+"222803_at",0.585580479599717,0.0657927916996993,1.93549962640277,-4.26323243320344,3.09118667174566,"PRTFDC1","phosphoribosyl transferase domain containing 1",TRUE
+"229178_at",0.766390367856479,0.266994910649637,1.13869019242122,-5.32714323609485,0.90988088513534,"PRTG","protogenin",TRUE
+"1562590_at",0.918775990454959,0.655168614242798,0.452696849778206,-5.84035741443466,0.27968498994306,"PRTG","protogenin",TRUE
+"229073_at",0.986984564305792,0.939994415144331,-0.0761357243830921,-5.9368605413118,-0.0776494157825418,"PRTG","protogenin",TRUE
+"207341_at",0.932918358096654,0.704010323251938,0.384860412235503,-5.86779726056559,0.274783800927505,"PRTN3","proteinase 3",TRUE
+"209586_s_at",0.780674131139921,0.302403634694592,-1.05587353812549,-5.41078780597616,-0.628171795323164,"PRUNE1","prune exopolyphosphatase",TRUE
+"210988_s_at",0.800887499728059,0.336834166552295,-0.981725499177499,-5.48085504967193,-0.461297140303722,"PRUNE1","prune exopolyphosphatase",TRUE
+"232490_s_at",0.871744769522775,0.513581416454657,-0.66393610552334,-5.72723154988168,-0.321205372465887,"PRUNE1","prune exopolyphosphatase",TRUE
+"209599_s_at",0.9116561917482,0.630643008929019,-0.487571365102105,-5.82455462035619,-0.207723325502194,"PRUNE1","prune exopolyphosphatase",TRUE
+"212806_at",0.85629081478032,0.470213708100015,-0.734722786105829,-5.68012393901176,-0.678046125246577,"PRUNE2","prune homolog 2",TRUE
+"212805_at",0.861665593344139,0.483810236513441,-0.712139706161267,-5.69564630246095,-0.441873697299823,"PRUNE2","prune homolog 2",TRUE
+"1552455_at",0.954672574687803,0.793530357023937,-0.26490647436827,-5.90556129379778,-0.1424066873804,"PRUNE2","prune homolog 2",TRUE
+"222255_at",0.782096995485383,0.303748584982409,1.05286859152687,-5.41371671740815,0.433748294874011,"PRX","periaxin",TRUE
+"220024_s_at",0.988066134679904,0.943122001585273,0.0721600051065578,-5.93714762892674,0.0451442643611113,"PRX","periaxin",TRUE
+"200871_s_at",0.819018525257656,0.374438802162574,0.906472535732147,-5.54720116221843,0.309051583892431,"PSAP","prosaposin",TRUE
+"200866_s_at",0.830635993561085,0.403495484170251,0.85169454276837,-5.59242005368028,0.284260054909625,"PSAP","prosaposin",TRUE
+"1564333_a_at",0.835897726578923,0.415593764848127,0.829636471932249,-5.60988742361737,0.267287648584559,"PSAPL1","prosaposin-like 1 (gene/pseudogene)",TRUE
+"220892_s_at",0.68747436517451,0.156248802519582,1.4676628128317,-4.94169050353763,1.54345622212575,"PSAT1","phosphoserine aminotransferase 1",TRUE
+"223062_s_at",0.727822268767891,0.208044539242389,1.29679551347558,-5.15219906911448,2.09954185148287,"PSAT1","phosphoserine aminotransferase 1",TRUE
+"205319_at",0.979883160726582,0.904073270102468,0.121904845637514,-5.93244792826689,0.1256427735714,"PSCA","prostate stem cell antigen",TRUE
+"208102_s_at",0.919375181609246,0.657295396234173,-0.449699946940166,-5.84166181885168,-0.289519549392212,"PSD","pleckstrin and Sec7 domain containing",TRUE
+"223536_at",0.695812999227098,0.165953918782147,-1.43251934267657,-4.98673925797866,-0.868206037525688,"PSD2","pleckstrin and Sec7 domain containing 2",TRUE
+"203354_s_at",0.908030744859333,0.618507197074554,-0.505054780925678,-5.81620116421229,-0.542926828938319,"PSD3","pleckstrin and Sec7 domain containing 3",TRUE
+"218613_at",0.976422537443518,0.888048484342028,0.142403272693202,-5.92981130151476,0.174644892094097,"PSD3","pleckstrin and Sec7 domain containing 3",TRUE
+"203355_s_at",0.983498417373669,0.919579082479157,-0.102121168537566,-5.93460530558096,-0.146892516465298,"PSD3","pleckstrin and Sec7 domain containing 3",TRUE
+"236616_at",0.821745015752602,0.38461608672704,0.886980795119527,-5.56359091516714,0.522116274403553,"PSD4","pleckstrin and Sec7 domain containing 4",TRUE
+"203317_at",0.955892698633978,0.799167086178113,-0.257502805318741,-5.90743895281638,-0.098784773095538,"PSD4","pleckstrin and Sec7 domain containing 4",TRUE
+"215923_s_at",0.984244246588495,0.923221512484983,-0.097480184667725,-5.93505627826307,-0.0376903992649087,"PSD4","pleckstrin and Sec7 domain containing 4",TRUE
+"1567443_x_at",0.751112081216662,0.244109318527309,-1.19660193415832,-5.26535126203963,-1.1085422138361,"PSEN1","presenilin 1",TRUE
+"1567440_at",0.812302873476553,0.360266069515038,0.934209619329868,-5.52331196267861,0.325881213611019,"PSEN1","presenilin 1",TRUE
+"1559206_at",0.812302873476553,0.360410371512265,0.933923571160752,-5.52356170873365,0.609455139264528,"PSEN1","presenilin 1",TRUE
+"203460_s_at",0.892689821944014,0.565186566220424,-0.583898088047898,-5.77497615573192,-0.199704443748152,"PSEN1","presenilin 1",TRUE
+"207782_s_at",0.907111393934291,0.615749866919976,-0.509049260555906,-5.81425232847489,-0.194558931520753,"PSEN1","presenilin 1",TRUE
+"238816_at",0.965707350334601,0.839757902717347,0.204592955980788,-5.91931639737288,0.132331895518036,"PSEN1","presenilin 1",TRUE
+"226577_at",0.97345342693821,0.871809425492962,0.163239773697311,-5.92671292870051,0.0522619384506573,"PSEN1","presenilin 1",TRUE
+"204262_s_at",0.83633038614858,0.417880842642566,0.825512482906281,-5.61310558404699,0.250699475249215,"PSEN2","presenilin 2",TRUE
+"211373_s_at",0.879006549665555,0.532613705530264,-0.633935281826869,-5.74581850764421,-0.227570881468761,"PSEN2","presenilin 2",TRUE
+"204261_s_at",0.990810941805126,0.954227663346281,0.05805190317509,-5.9380421998671,0.02069048194969,"PSEN2","presenilin 2",TRUE
+"218302_at",0.73005042632231,0.212572524683149,-1.28351849876048,-5.16764051758913,-0.592304008153747,"PSENEN","presenilin enhancer gamma-secretase subunit",TRUE
+"210196_s_at",0.884329174014288,0.543358208235769,0.617255405261121,-5.7557949358049,0.848391233661144,"PSG1","pregnancy specific beta-1-glycoprotein 1",TRUE
+"208257_x_at",0.96287357728432,0.831330755308628,-0.215523587005538,-5.91708448636435,-0.300669694597849,"PSG1","pregnancy specific beta-1-glycoprotein 1",TRUE
+"210195_s_at",0.96287357728432,0.831462543406994,-0.21535244479734,-5.91712032274347,-0.209863493828086,"PSG1","pregnancy specific beta-1-glycoprotein 1",TRUE
+"206570_s_at",0.91339551560427,0.6369231757845,-0.47858435314438,-5.82873664318469,-0.43662657012909,"PSG11","pregnancy specific beta-1-glycoprotein 11",TRUE
+"203399_x_at",0.82064687791745,0.381517588169396,-0.892878854076483,-5.55866627936182,-0.846821446418816,"PSG11///PSG3","pregnancy specific beta-1-glycoprotein 11///pregnancy specific beta-1-glycoprotein 3",TRUE
+"215821_x_at",0.943824539742785,0.748489953297562,-0.32465172733356,-5.88847762099565,-0.306989619340884,"PSG11///PSG3","pregnancy specific beta-1-glycoprotein 11///pregnancy specific beta-1-glycoprotein 3",TRUE
+"208134_x_at",0.963796115120365,0.834669477895765,0.211189880537266,-5.91798321596112,0.230759237296875,"PSG2","pregnancy specific beta-1-glycoprotein 2",TRUE
+"211741_x_at",0.943090724841892,0.744489735421346,-0.330013405012401,-5.88677676616948,-0.361503080933082,"PSG3","pregnancy specific beta-1-glycoprotein 3",TRUE
+"208191_x_at",0.972112264314695,0.866219417952006,-0.170429041874915,-5.92554611101954,-0.133548481750667,"PSG4","pregnancy specific beta-1-glycoprotein 4",TRUE
+"239583_x_at",0.901781358899845,0.598718662901733,0.533912222707242,-5.80178586169535,0.384253081397956,"PSG5","pregnancy specific beta-1-glycoprotein 5",TRUE
+"204830_x_at",0.991689960875868,0.961398180513832,-0.0489494153389972,-5.93851652282616,-0.061045868585377,"PSG5","pregnancy specific beta-1-glycoprotein 5",TRUE
+"209738_x_at",0.868397087637799,0.503519076155494,-0.680046748569025,-5.71691041687646,-0.666346201198143,"PSG6","pregnancy specific beta-1-glycoprotein 6",TRUE
+"208106_x_at",0.87259234900665,0.515942669569035,-0.660181138661778,-5.72960306984994,-0.387628409056987,"PSG6","pregnancy specific beta-1-glycoprotein 6",TRUE
+"239910_at",0.986421906591669,0.936389340423448,0.080719981004539,-5.93651041427457,0.047630246316329,"PSG6","pregnancy specific beta-1-glycoprotein 6",TRUE
+"1568999_at",0.968451827985008,0.852099230183194,-0.188630846438919,-5.92236784204666,-0.229433636678202,"PSG6///PSG4","pregnancy specific beta-1-glycoprotein 6///pregnancy specific beta-1-glycoprotein 4",TRUE
+"205602_x_at",0.961212424803935,0.823119066103848,-0.226200640137585,-5.91479273632782,-0.251279601469347,"PSG7","pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)",TRUE
+"209594_x_at",0.843475287501313,0.438706942898177,-0.788592524731403,-5.64124547180136,-0.724364830584533,"PSG9","pregnancy specific beta-1-glycoprotein 9",TRUE
+"207733_x_at",0.916664917121013,0.647407695923693,-0.463669020350065,-5.83550931923971,-0.494466625128106,"PSG9","pregnancy specific beta-1-glycoprotein 9",TRUE
+"210126_at",0.923935703779429,0.672961821630188,-0.427750191958904,-5.85095623626227,-0.458957696125526,"PSG9","pregnancy specific beta-1-glycoprotein 9",TRUE
+"1554933_at",0.73826901296725,0.225113515793568,1.24784932017246,-5.20845208260978,1.11930928204653,"PSIP1","PC4 and SFRS1 interacting protein 1",TRUE
+"209337_at",0.789824589976275,0.318648898330366,1.02019065526768,-5.44508232555209,0.614808336789322,"PSIP1","PC4 and SFRS1 interacting protein 1",TRUE
+"205961_s_at",0.953553103224247,0.785828911295439,0.27504668596636,-5.90290384773039,0.163463410118402,"PSIP1","PC4 and SFRS1 interacting protein 1",TRUE
+"210758_at",0.982093200363011,0.913995527111842,-0.109239927407123,-5.93387285117178,-0.0640880423352614,"PSIP1","PC4 and SFRS1 interacting protein 1",TRUE
+"213141_at",0.722160153958635,0.198395288214064,-1.32585516753822,-5.11793276946045,-0.471270569214845,"PSKH1","protein serine kinase H1",TRUE
+"1553060_at",0.956619372543067,0.803056955766935,0.252402171029824,-5.90870176799906,0.120494019149679,"PSKH2","protein serine kinase H2",TRUE
+"210759_s_at",0.690937549779432,0.160643770147163,1.45153592268229,-4.96247309504968,0.475346606844656,"PSMA1","proteasome subunit alpha 1",TRUE
+"211746_x_at",0.764430688544079,0.264558877194493,1.14467541050601,-5.32088167189461,0.333305542007176,"PSMA1","proteasome subunit alpha 1",TRUE
+"201676_x_at",0.792716268502624,0.324392109854691,1.00788164209663,-5.45666536930367,0.30319148971982,"PSMA1","proteasome subunit alpha 1",TRUE
+"201316_at",0.900736310608905,0.596203254237067,-0.537612994502545,-5.79988080608704,-0.248867162109153,"PSMA2","proteasome subunit alpha 2",TRUE
+"201317_s_at",0.948764595648089,0.766925018147308,-0.300064619461574,-5.89592381440635,-0.0684591927373503,"PSMA2","proteasome subunit alpha 2",TRUE
+"232648_at",0.860085676417428,0.479329279307358,-0.719540861890458,-5.69060991501337,-0.552172342613234,"PSMA3","proteasome subunit alpha 3",TRUE
+"237300_at",0.864894115958506,0.493249896205296,-0.696677057821135,-5.70600830470032,-0.251222548413797,"PSMA3","proteasome subunit alpha 3",TRUE
+"201532_at",0.971216837324271,0.862263484696645,-0.175522277466921,-5.92468913640284,-0.046416747531028,"PSMA3","proteasome subunit alpha 3",TRUE
+"225724_at",0.384135218769668,0.0124613681824751,-2.71981143313932,-2.86386787817048,-0.731795966947555,"PSMA3-AS1","PSMA3 antisense RNA 1",TRUE
+"239432_at",0.567519318225104,0.0575667515112287,-2.00294486268964,-4.15442291373576,-0.951276577664218,"PSMA3-AS1","PSMA3 antisense RNA 1",TRUE
+"241774_at",0.939166148226364,0.727510897073557,-0.352883333586819,-5.87921248007285,-0.177775407255958,"PSMA3-AS1","PSMA3 antisense RNA 1",TRUE
+"203396_at",0.942684843065067,0.743425997874749,-0.331440837570231,-5.88631930279387,-0.091227772876028,"PSMA4","proteasome subunit alpha 4",TRUE
+"230300_at",0.465776708318531,0.0241200679254859,-2.42083771659236,-3.42872701845571,-1.49950717108551,"PSMA5","proteasome subunit alpha 5",TRUE
+"201274_at",0.979588787486838,0.901723937443839,-0.124906482731023,-5.93208735809001,-0.0528883387499786,"PSMA5","proteasome subunit alpha 5",TRUE
+"216088_s_at",0.944654135079729,0.751180172651991,-0.321051363269621,-5.88960426682384,-0.123256905267693,"PSMA7","proteasome subunit alpha 7",TRUE
+"201114_x_at",0.966593471043185,0.844761594781742,0.19811493027938,-5.92058454521856,0.0603510631232087,"PSMA7","proteasome subunit alpha 7",TRUE
+"240091_at",0.346761268605178,0.00890062411074527,2.86784281561278,-2.57294840607331,1.6288839137712,"PSMA8","proteasome subunit alpha 8",TRUE
+"200876_s_at",0.887798891751858,0.553047379489058,0.602363793787895,-5.76448507425482,0.177642905561203,"PSMB1","proteasome subunit beta 1",TRUE
+"214288_s_at",0.902212740485572,0.600694533836292,0.531010525368179,-5.8032706212653,0.150494394607938,"PSMB1","proteasome subunit beta 1",TRUE
+"214289_at",0.993213867476782,0.967601036876649,0.041078753751467,-5.93886161266843,0.0296225013412261,"PSMB1","proteasome subunit beta 1",TRUE
+"202659_at",0.915742010892393,0.644554854575533,0.467716784245285,-5.8336920843374,0.301830514032222,"PSMB10","proteasome subunit beta 10",TRUE
+"200039_s_at",0.599747222491044,0.0762533600461643,1.85972676633434,-4.38239663746174,0.498417114565019,"PSMB2","proteasome subunit beta 2",TRUE
+"238425_at",0.685171748325522,0.15380178998078,1.47680178195014,-4.92983066105402,0.737935813080254,"PSMB2","proteasome subunit beta 2",TRUE
+"201404_x_at",0.790817398514927,0.320583538976598,1.01602710615002,-5.44901455259084,0.309436192860424,"PSMB2","proteasome subunit beta 2",TRUE
+"231323_at",0.954577684533304,0.792526375338432,-0.266226749797179,-5.9052209019298,-0.233888393217842,"PSMB2","proteasome subunit beta 2",TRUE
+"201400_at",0.980009054680439,0.905814273130086,0.119681185441743,-5.93270939722655,0.0522326409091427,"PSMB3","proteasome subunit beta 3",TRUE
+"202244_at",0.975449397348071,0.882631898672769,-0.149345710559568,-5.92882579131107,-0.0389836134113306,"PSMB4","proteasome subunit beta 4",TRUE
+"202243_s_at",0.988065316951061,0.943054081962448,0.0722463301454847,-5.93714155878028,0.0227707015232905,"PSMB4","proteasome subunit beta 4",TRUE
+"228204_at",0.991215113882097,0.958750313058398,0.0523101690269504,-5.93835079159147,0.0174401397351325,"PSMB4","proteasome subunit beta 4",TRUE
+"208799_at",0.85334340854827,0.46127808153106,-0.749774604608214,-5.66952279424334,-0.242595036855162,"PSMB5","proteasome subunit beta 5",TRUE
+"208827_at",0.559737572161473,0.0541054059236102,2.03391324323534,-4.10362489777796,0.687844414007213,"PSMB6","proteasome subunit beta 6",TRUE
+"200786_at",0.853768202875953,0.462446445348232,0.74779673182714,-5.67092745677607,0.187422406254502,"PSMB7","proteasome subunit beta 7",TRUE
+"244801_at",0.936992192746977,0.718810706184315,-0.364676172439745,-5.87511635083118,-0.347778856482519,"PSMB7","proteasome subunit beta 7",TRUE
+"209040_s_at",0.616571701365701,0.0874533798644904,1.78805131387037,-4.49199583542278,3.54238787772694,"PSMB8","proteasome subunit beta 8",TRUE
+"1555852_at",0.54295328972902,0.0462366806946195,2.11148651346232,-3.9741476935736,1.99357517033099,"PSMB8-AS1","PSMB8 antisense RNA 1 (head to head)",TRUE
+"1555853_at",0.812302873476553,0.358962914354629,0.936796338549309,-5.52105033114621,0.491417333579992,"PSMB8-AS1","PSMB8 antisense RNA 1 (head to head)",TRUE
+"204279_at",0.493519901382617,0.0298339200188708,2.32164155822486,-3.60837103160429,3.36047711216755,"PSMB9","proteasome subunit beta 9",TRUE
+"204219_s_at",0.977874971442423,0.892901492007728,0.136189264194612,-5.93065370543138,0.034446163235561,"PSMC1","proteasome 26S subunit, ATPase 1",TRUE
+"201068_s_at",0.869793539734051,0.507558534709006,0.673557744915911,-5.7210960234721,0.189032614302317,"PSMC2","proteasome 26S subunit, ATPase 2",TRUE
+"238020_at",0.978928101156583,0.897267934897218,-0.130602971612036,-5.93137899196211,-0.0576034505305643,"PSMC2","proteasome 26S subunit, ATPase 2",TRUE
+"201067_at",0.996530665727182,0.982733249834078,0.0218879635362667,-5.93945013980283,0.00951651938377296,"PSMC2","proteasome 26S subunit, ATPase 2",TRUE
+"201267_s_at",0.976371465776674,0.886209294429957,-0.144759741461308,-5.92948203765306,-0.056156844259112,"PSMC3","proteasome 26S subunit, ATPase 3",TRUE
+"205956_x_at",0.967106491969364,0.846700583676818,0.195606965419093,-5.92106459433739,0.0530528139225357,"PSMC3IP","PSMC3 interacting protein",TRUE
+"213951_s_at",0.977063818674184,0.890493820572538,0.139271452607695,-5.93024055602002,0.0586500724800914,"PSMC3IP","PSMC3 interacting protein",TRUE
+"201252_at",0.964181293782946,0.835501143061762,0.210111014649675,-5.91820412684391,0.0701462474395367,"PSMC4","proteasome 26S subunit, ATPase 4",TRUE
+"209503_s_at",0.92346045063848,0.67146811561841,-0.429833620920941,-5.85009364168823,-0.164215192580015,"PSMC5","proteasome 26S subunit, ATPase 5",TRUE
+"201699_at",0.979976490833035,0.904562366602909,-0.121280094127588,-5.93252187514748,-0.0377425837711094,"PSMC6","proteasome 26S subunit, ATPase 6",TRUE
+"201198_s_at",0.782876787164404,0.30519529458645,1.0496468181019,-5.41684864170502,0.257093778755396,"PSMD1","proteasome 26S subunit, non-ATPase 1",TRUE
+"201199_s_at",0.90415231543826,0.606471389420413,0.522553111040994,-5.80755323027555,0.148066006341553,"PSMD1","proteasome 26S subunit, non-ATPase 1",TRUE
+"1554577_a_at",0.605963335055725,0.0794873166715987,-1.83814045000399,-4.41572930267555,-0.491145393492653,"PSMD10","proteasome 26S subunit, non-ATPase 10",TRUE
+"219485_s_at",0.774230543658252,0.287782393265203,-1.08917371811429,-5.3778303957642,-0.296854534728853,"PSMD10","proteasome 26S subunit, non-ATPase 10",TRUE
+"208776_at",0.645740804644555,0.116710788870094,1.63247932164045,-4.71887022687797,1.26123299386819,"PSMD11","proteasome 26S subunit, non-ATPase 11",TRUE
+"208777_s_at",0.745717401914776,0.237377992087116,1.21440522331572,-5.24581857559455,0.418874308402748,"PSMD11","proteasome 26S subunit, non-ATPase 11",TRUE
+"202353_s_at",0.758966211371161,0.256421671367502,-1.16496775767205,-5.2994377296068,-0.457460970535704,"PSMD12","proteasome 26S subunit, non-ATPase 12",TRUE
+"202352_s_at",0.959869386255065,0.818528478632673,0.232181099113189,-5.91346090704471,0.0824893716397934,"PSMD12","proteasome 26S subunit, non-ATPase 12",TRUE
+"201233_at",0.930827859648584,0.69332264319254,0.399537292937774,-5.86223123961588,0.149159715696381,"PSMD13","proteasome 26S subunit, non-ATPase 13",TRUE
+"201232_s_at",0.990810941805126,0.956089412388485,-0.0556880870291911,-5.93817313144819,-0.0231368112475572,"PSMD13","proteasome 26S subunit, non-ATPase 13",TRUE
+"212296_at",0.963505878933446,0.83359938004968,0.212578427330222,-5.91769723615554,0.0565973447372947,"PSMD14","proteasome 26S subunit, non-ATPase 14",TRUE
+"200830_at",0.682825347106105,0.151082337938304,1.48709788607376,-4.91639801781128,0.411657360029638,"PSMD2","proteasome 26S subunit, non-ATPase 2",TRUE
+"201388_at",0.994304286761558,0.974135005194305,0.0327908171661485,-5.93915978568377,0.0183037152983196,"PSMD3","proteasome 26S subunit, non-ATPase 3",TRUE
+"210459_at",0.776954388941225,0.295474470684879,1.07150769231038,-5.39542855080587,0.674698299933178,"PSMD4","proteasome 26S subunit, non-ATPase 4",TRUE
+"200882_s_at",0.953931868692178,0.787335130139672,-0.273061218076798,-5.90343198219936,-0.0967370420189031,"PSMD4","proteasome 26S subunit, non-ATPase 4",TRUE
+"211609_x_at",0.983212176432519,0.918292416582258,-0.103761111385575,-5.9344409398962,-0.0333705944303624,"PSMD4","proteasome 26S subunit, non-ATPase 4",TRUE
+"210460_s_at",0.989549062521614,0.949044063858177,0.0646352192073851,-5.93764887631785,0.0218925604606621,"PSMD4","proteasome 26S subunit, non-ATPase 4",TRUE
+"215546_at",0.733945983292434,0.218091647500432,1.26762719128446,-5.18594434464562,0.841836703552203,"PSMD5","proteasome 26S subunit, non-ATPase 5",TRUE
+"203447_at",0.740476003158683,0.229774410051947,-1.23498016248286,-5.22293416806566,-0.397986180282121,"PSMD5","proteasome 26S subunit, non-ATPase 5",TRUE
+"1555892_s_at",0.622434989367596,0.0926452130020979,-1.75748656087419,-4.53777992815216,-0.718923340878266,"PSMD5-AS1","PSMD5 antisense RNA 1 (head to head)",TRUE
+"231828_at",0.726696341943087,0.206891913474915,-1.30021093702936,-5.14820504187306,-0.593974648770343,"PSMD5-AS1","PSMD5 antisense RNA 1 (head to head)",TRUE
+"241249_at",0.948988685362499,0.769830229616079,0.296207452599172,-5.89703924095725,0.110953731095137,"PSMD5-AS1","PSMD5 antisense RNA 1 (head to head)",TRUE
+"239958_at",0.961561244483099,0.825951553232017,0.22251479174754,-5.9155963385152,0.156362430338209,"PSMD5-AS1","PSMD5 antisense RNA 1 (head to head)",TRUE
+"202753_at",0.831432775543015,0.405733111737781,-0.847583381055271,-5.59570803889628,-0.445655714368018,"PSMD6","proteasome 26S subunit, non-ATPase 6",TRUE
+"1555884_at",0.985498770484702,0.930230856179418,0.0885553414743992,-5.93586462974454,0.0876349288688458,"PSMD6","proteasome 26S subunit, non-ATPase 6",TRUE
+"232284_at",0.929088231432081,0.687918518026606,-0.406992449976518,-5.85932541276376,-0.322035640209512,"PSMD6-AS2","PSMD6 antisense RNA 2",TRUE
+"232527_at",0.971511156698413,0.864320294883278,-0.172873564788179,-5.9251379419783,-0.0901651950448272,"PSMD6-AS2","PSMD6 antisense RNA 2",TRUE
+"201705_at",0.904432955312383,0.608281822272463,-0.519910557377542,-5.80887761898604,-0.197096885785488,"PSMD7","proteasome 26S subunit, non-ATPase 7",TRUE
+"200820_at",0.692556441093824,0.162071507339652,-1.4463737326253,-4.96908612007903,-0.440915263639061,"PSMD8","proteasome 26S subunit, non-ATPase 8",TRUE
+"207805_s_at",0.728385463227073,0.208812961622591,-1.29452668764814,-5.1548473260157,-0.48657459072566,"PSMD9","proteasome 26S subunit, non-ATPase 9",TRUE
+"209334_s_at",0.91543081876046,0.643606047977176,0.469064757832295,-5.83308348174565,0.154384648189497,"PSMD9","proteasome 26S subunit, non-ATPase 9",TRUE
+"200814_at",0.857675459113089,0.473223513032731,0.729691012423196,-5.68362236919668,0.232665876419025,"PSME1","proteasome activator subunit 1",TRUE
+"200988_s_at",0.932249295738588,0.701165289262801,0.388758829908474,-5.86633885357239,0.178752104905129,"PSME3","proteasome activator subunit 3",TRUE
+"200987_x_at",0.952293443370532,0.781537835040413,0.280709324835774,-5.90137672328177,0.089259422056033,"PSME3","proteasome activator subunit 3",TRUE
+"209852_x_at",0.961212424803935,0.824327708177982,-0.224627473914335,-5.91513733085472,-0.0726310653804241,"PSME3","proteasome activator subunit 3",TRUE
+"209853_s_at",0.991059530537351,0.958387269383445,0.0527710023147811,-5.93832720874515,0.0191934695175764,"PSME3","proteasome activator subunit 3",TRUE
+"212222_at",0.480603497646452,0.0271044696974478,2.36661233117428,-3.52745237158285,0.745581565819027,"PSME4","proteasome activator subunit 4",TRUE
+"212220_at",0.579119470758542,0.062230232009243,1.96373731057423,-4.21798461785592,0.733084280667551,"PSME4","proteasome activator subunit 4",TRUE
+"212219_at",0.61823092358054,0.0891713999868519,1.77776833094154,-4.50746358693955,0.550947722012866,"PSME4","proteasome activator subunit 4",TRUE
+"236012_at",0.8920930097751,0.562883827415446,0.587385029510477,-5.77301927620642,0.158261470564752,"PSMF1","proteasome inhibitor subunit 1",TRUE
+"201053_s_at",0.892689821944014,0.565231439339366,-0.583830211224422,-5.77501413650635,-0.268098791285654,"PSMF1","proteasome inhibitor subunit 1",TRUE
+"235993_at",0.954577684533304,0.791750980824984,0.267246754960447,-5.90495677456656,0.076149065368047,"PSMF1","proteasome inhibitor subunit 1",TRUE
+"201052_s_at",0.993083193605528,0.967055419396654,-0.0417709611333424,-5.93883368230553,-0.0159048174341159,"PSMF1","proteasome inhibitor subunit 1",TRUE
+"203405_at",0.792436690618566,0.323710245995709,1.00933504089257,-5.45530431846319,0.464272208869563,"PSMG1","proteasome assembly chaperone 1",TRUE
+"218467_at",0.632949074657601,0.104032347004731,1.69527737174616,-4.62915567111227,0.575769208296979,"PSMG2","proteasome assembly chaperone 2",TRUE
+"223363_at",0.921716759218618,0.665911910487327,0.437600538858675,-5.84684165937895,0.152710074774328,"PSMG3","proteasome assembly chaperone 3",TRUE
+"1561666_a_at",0.071020853517731,0.00020303805853397,-4.43981906091713,0.749264854590158,-2.52795820478495,"PSMG3-AS1","PSMG3 antisense RNA 1 (head to head)",TRUE
+"228217_s_at",0.480347694747353,0.0270593671663803,2.36738989688707,-3.52604551850235,1.35270229407128,"PSMG4","proteasome assembly chaperone 4",TRUE
+"242623_x_at",0.843475287501313,0.438691392437211,0.788619682620896,-5.64122521727266,0.737008572391904,"PSMG4","proteasome assembly chaperone 4",TRUE
+"233447_at",0.91269009113888,0.633674813977132,-0.483227768287627,-5.82658537076581,-0.325908094791186,"PSMG4","proteasome assembly chaperone 4",TRUE
+"242055_at",0.937113154905832,0.720919894091983,-0.361812455793882,-5.87612325885073,-0.214692678279596,"PSMG4","proteasome assembly chaperone 4",TRUE
+"233443_at",0.985498770484702,0.929812826007389,0.0890873961571417,-5.9358186121549,0.0468660798275735,"PSMG4","proteasome assembly chaperone 4",TRUE
+"220362_at",0.358427723880268,0.00981989445266072,2.82486114201368,-2.65809846218972,1.82384515322065,"PSORS1C1","psoriasis susceptibility 1 candidate 1",TRUE
+"220635_at",0.597346378847428,0.0733991168147179,1.87945175766429,-4.35169723148787,0.478007390781611,"PSORS1C2","psoriasis susceptibility 1 candidate 2",TRUE
+"238997_at",0.931582451098271,0.697584263466886,-0.393674484659093,-5.86447924965538,-0.240757665857496,"PSORS1C3","psoriasis susceptibility 1 candidate 3 (non-protein coding)",TRUE
+"226574_at",0.0823353801878483,0.000294528105477779,-4.28809109838255,0.421555960693561,-1.24270626989522,"PSPC1","paraspeckle component 1",TRUE
+"226724_s_at",0.817915083386752,0.370922700287376,0.913287770942558,-5.54139288217163,0.298217955187488,"PSPC1","paraspeckle component 1",TRUE
+"222611_s_at",0.896907177224677,0.582052516894991,-0.55857640010176,-5.78884810424091,-0.256674525064266,"PSPC1","paraspeckle component 1",TRUE
+"218371_s_at",0.903919439852106,0.605857114077977,0.523450578615504,-5.80710195193114,0.306040944981936,"PSPC1","paraspeckle component 1",TRUE
+"222612_at",0.939899468413492,0.729788320258519,-0.349804829892835,-5.88025987458071,-0.135190863040688,"PSPC1","paraspeckle component 1",TRUE
+"244819_x_at",0.729273475042162,0.211471562060996,1.28672648591555,-5.16392194269612,1.15664499176953,"PSPH","phosphoserine phosphatase",TRUE
+"205048_s_at",0.774230543658252,0.286794749719669,1.09146651096468,-5.37552759742774,0.911571531423789,"PSPH","phosphoserine phosphatase",TRUE
+"205194_at",0.952339611416198,0.78190260917189,0.280227595362773,-5.90150784016838,0.149340982973449,"PSPH","phosphoserine phosphatase",TRUE
+"221373_x_at",0.818268955967428,0.371303226664589,-0.912548139518203,-5.54202517442553,-0.588411671448014,"PSPN","persephin",TRUE
+"201896_s_at",0.873481606879925,0.518784830309897,-0.65567402411512,-5.73243259111586,-0.304751298520456,"PSRC1","proline and serine rich coiled-coil 1",TRUE
+"240040_at",0.606900628956089,0.0806047574977268,1.83085895005251,-4.42691039051459,0.921913186784735,"PSTK","phosphoseryl-tRNA kinase",TRUE
+"230129_at",0.959203345279235,0.815288940696145,0.236406661043579,-5.9124990448752,0.0947142970399035,"PSTK","phosphoseryl-tRNA kinase",TRUE
+"211178_s_at",0.76912869907427,0.274893534045793,1.11955516975573,-5.34696727463828,0.370403879256586,"PSTPIP1","proline-serine-threonine phosphatase interacting protein 1",TRUE
+"219938_s_at",0.955129558776714,0.794954288096811,0.263034773026765,-5.90604097305815,0.18013109881473,"PSTPIP2","proline-serine-threonine phosphatase interacting protein 2",TRUE
+"227184_at",0.599747222491044,0.0762502776883876,1.8597477179233,-4.38236415059375,1.06254188449391,"PTAFR","platelet activating factor receptor",TRUE
+"211661_x_at",0.641112145892678,0.111588510063243,1.65712236589309,-4.68397221231312,0.97090898952192,"PTAFR","platelet activating factor receptor",TRUE
+"206278_at",0.670164229230396,0.136073805102,1.54681211578682,-4.83702292204867,0.99926172929917,"PTAFR","platelet activating factor receptor",TRUE
+"226110_at",0.713724591137462,0.188939008188678,-1.35542588741885,-5.08240845633885,-0.610548435178892,"PTAR1","protein prenyltransferase alpha subunit repeat containing 1",TRUE
+"235484_at",0.758592188796388,0.255597353488926,-1.16704989618131,-5.29721873327361,-0.489071735584075,"PTAR1","protein prenyltransferase alpha subunit repeat containing 1",TRUE
+"243995_at",0.983567332578112,0.920066633525725,0.101499826897706,-5.93466689716061,0.0402677607503668,"PTAR1","protein prenyltransferase alpha subunit repeat containing 1",TRUE
+"231158_x_at",0.78578093265889,0.311287912325889,1.03619621076861,-5.42983086303707,0.564116249213964,"PTBP1","polypyrimidine tract binding protein 1",TRUE
+"236819_at",0.899808883319249,0.593613594188895,-0.541430961030188,-5.79790201196672,-0.260154575573958,"PTBP1","polypyrimidine tract binding protein 1",TRUE
+"211270_x_at",0.908709061737317,0.620697674190211,0.501887415270316,-5.81773581730795,0.12331655627148,"PTBP1","polypyrimidine tract binding protein 1",TRUE
+"226491_x_at",0.96882227301574,0.852831701656075,0.187685093815137,-5.92254089335655,0.0957752095099931,"PTBP1","polypyrimidine tract binding protein 1",TRUE
+"218683_at",0.940900986249919,0.735270242075972,-0.342408691107499,-5.88273917378412,-0.164077337061759,"PTBP2","polypyrimidine tract binding protein 2",TRUE
+"1554614_a_at",0.953983577550391,0.788673347207667,-0.271298147188653,-5.90389777462375,-0.176433037260883,"PTBP2","polypyrimidine tract binding protein 2",TRUE
+"224617_at",0.64513208805899,0.116117483873447,-1.6352865748793,-4.71491500362618,-0.919413181788014,"PTBP3","polypyrimidine tract binding protein 3",TRUE
+"224618_at",0.709914655587487,0.182698242028668,-1.37558594897978,-5.05781431995943,-0.674753776151928,"PTBP3","polypyrimidine tract binding protein 3",TRUE
+"214697_s_at",0.730053120402013,0.21259353903708,-1.28345739198057,-5.16771127350904,-0.781575055507764,"PTBP3","polypyrimidine tract binding protein 3",TRUE
+"207223_s_at",0.851733415458562,0.45660097813857,-0.757722422473946,-5.66384293255885,-0.360551338373389,"PTBP3","polypyrimidine tract binding protein 3",TRUE
+"214698_at",0.91671872326659,0.647594795187447,-0.463403829206888,-5.83562783628326,-0.221225095270428,"PTBP3","polypyrimidine tract binding protein 3",TRUE
+"1555910_at",0.833956476774481,0.411815105924723,-0.83648155940877,-5.60451274513461,-0.304986638573936,"PTCD2","pentatricopeptide repeat domain 2",TRUE
+"219658_at",0.901202286701133,0.59783445334411,0.535212245439754,-5.8011181041513,0.484886317667936,"PTCD2","pentatricopeptide repeat domain 2",TRUE
+"228590_at",0.691295036264984,0.161017113697293,-1.45018248099642,-4.96420877674409,-0.786270821800421,"PTCD3","pentatricopeptide repeat domain 3",TRUE
+"228020_at",0.717937808890208,0.193853056655622,-1.33991783722289,-5.10112079110593,-0.431280707595281,"PTCD3","pentatricopeptide repeat domain 3",TRUE
+"217895_at",0.897699110987203,0.584895161033474,-0.554345149592981,-5.79110795060774,-0.173329194887257,"PTCD3","pentatricopeptide repeat domain 3",TRUE
+"228512_at",0.899808883319249,0.592877915232643,-0.542517065298724,-5.79733661356615,-0.180275210592837,"PTCD3","pentatricopeptide repeat domain 3",TRUE
+"1555520_at",0.584247456664678,0.0648273362897563,1.94301620535199,-4.25123177540757,0.770386000569791,"PTCH1","patched 1",TRUE
+"209816_at",0.819018525257656,0.375246341590247,0.904913271869917,-5.54852439747357,0.563596545290296,"PTCH1","patched 1",TRUE
+"208522_s_at",0.837368340567858,0.421230883795705,-0.81949735417086,-5.61777257148773,-0.569673386387124,"PTCH1","patched 1",TRUE
+"209815_at",0.915939421175188,0.645090876968316,0.466955643719785,-5.83403497751118,0.544363419299107,"PTCH1","patched 1",TRUE
+"238754_at",0.994825233837873,0.975883979728587,-0.0305727745817696,-5.93922823575223,-0.011410575251066,"PTCH1","patched 1",TRUE
+"221292_at",0.986145735582101,0.932203718731379,0.0860446994405651,-5.93607805944352,0.031037255767786,"PTCH2","patched 2",TRUE
+"1552848_a_at",0.930899509890345,0.694508678557753,-0.397904214237778,-5.8628607088968,-0.230206350467116,"PTCHD1","patched domain containing 1",TRUE
+"240041_at",0.967167123162441,0.846914684145372,-0.195330118389276,-5.9211172121571,-0.201325729491503,"PTCHD1","patched domain containing 1",TRUE
+"234689_at",0.686108994812404,0.154844328938928,-1.47289384114139,-4.93490936672769,-0.76981822773891,"PTCHD4","patched domain containing 4",TRUE
+"211252_x_at",0.691295036264984,0.160953748877129,1.45041201193437,-4.963914514279,0.476374052350273,"PTCRA","pre T-cell antigen receptor alpha",TRUE
+"211837_s_at",0.729273475042162,0.211678352044448,1.2861229586488,-5.16462213154003,0.719445892163145,"PTCRA","pre T-cell antigen receptor alpha",TRUE
+"215492_x_at",0.745508528302503,0.237037997006077,1.21531449993444,-5.24481425934404,0.491693299829882,"PTCRA","pre T-cell antigen receptor alpha",TRUE
+"233111_at",0.934081042629428,0.70812359597163,0.37923488463509,-5.86987623893839,0.128462431927099,"PTCSC1","papillary thyroid carcinoma susceptibility candidate 1 (non-protein coding)",TRUE
+"201433_s_at",0.990870307890695,0.956932747139697,-0.054617433835009,-5.93823064466344,-0.0210014147887652,"PTDSS1","phosphatidylserine synthase 1",TRUE
+"221005_s_at",0.969882914559333,0.857248585994692,-0.181985779243844,-5.9235653847664,-0.0866261613947668,"PTDSS2","phosphatidylserine synthase 2",TRUE
+"242622_x_at",0.645803111489595,0.117030036189097,-1.63097373939513,-4.72098933374763,-1.53489101489298,"PTEN","phosphatase and tensin homolog",TRUE
+"228006_at",0.792498583980175,0.324058360165428,-1.00859276648839,-5.45599965127264,-0.451916485202535,"PTEN","phosphatase and tensin homolog",TRUE
+"225363_at",0.904832003218088,0.610131728792493,-0.517214253451596,-5.81022220328631,-0.229535743827949,"PTEN","phosphatase and tensin homolog",TRUE
+"204054_at",0.988224361618126,0.943995666856248,-0.0710496367179988,-5.93722506035714,-0.0330628178669858,"PTEN","phosphatase and tensin homolog",TRUE
+"204053_x_at",0.991689960875868,0.961102904668043,0.0493241590502096,-5.9384985876427,0.0287372464150355,"PTEN","phosphatase and tensin homolog",TRUE
+"211711_s_at",0.99187501204911,0.962636953702374,-0.0473773276034438,-5.93859027254063,-0.0247858056965757,"PTEN","phosphatase and tensin homolog",TRUE
+"233254_x_at",0.994050962712312,0.972169834897664,0.0352832400812275,-5.93907715062428,0.0174236065405493,"PTEN","phosphatase and tensin homolog",TRUE
+"217494_s_at",0.737488397392592,0.223556269409411,1.25219430198426,-5.2035333969836,0.815123989978663,"PTENP1","phosphatase and tensin homolog pseudogene 1",TRUE
+"217492_s_at",0.957524414951038,0.808348503354276,0.245474512960105,-5.91037670216441,0.139323026326702,"PTENP1///PTEN","phosphatase and tensin homolog pseudogene 1///phosphatase and tensin homolog",TRUE
+"218967_s_at",0.525243770035611,0.0391960115432829,2.19171730754576,-3.83700545830485,1.31423761717494,"PTER","phosphotriesterase related",TRUE
+"222798_at",0.61299046462692,0.0845408550124835,1.80588876317561,-4.46501079055864,1.2582373813865,"PTER","phosphotriesterase related",TRUE
+"234165_at",0.718812966125406,0.19485159236708,1.3368044254552,-5.10485573363029,0.622369096992019,"PTGDR","prostaglandin D2 receptor",TRUE
+"215894_at",0.943988850936011,0.749760638602793,-0.322950606065741,-5.88901149535516,-0.257020753297271,"PTGDR","prostaglandin D2 receptor",TRUE
+"215937_at",0.972659629123427,0.867764659098591,-0.168440815235264,-5.9258738163393,-0.0609826994951961,"PTGDR","prostaglandin D2 receptor",TRUE
+"216464_x_at",0.565043084457947,0.0562014641454264,2.01495678587344,-4.1347810734807,0.869846839579814,"PTGDR2","prostaglandin D2 receptor 2",TRUE
+"206361_at",0.89565571257902,0.574952989725342,0.569189386127531,-5.78310654463329,0.315097334433819,"PTGDR2","prostaglandin D2 receptor 2",TRUE
+"211663_x_at",0.624965128767163,0.0962680624504261,-1.73701809821996,-4.56811517154124,-0.651179650292548,"PTGDS","prostaglandin D2 synthase",TRUE
+"211748_x_at",0.638134354959023,0.109358959656263,-1.6681473575387,-4.66823009595328,-1.40800759804207,"PTGDS","prostaglandin D2 synthase",TRUE
+"212187_x_at",0.689950875648652,0.159366979580555,-1.45618381765216,-4.95650251519262,-1.53210557027721,"PTGDS","prostaglandin D2 synthase",TRUE
+"231201_at",0.837368340567858,0.420827250757098,0.820220497213253,-5.61721319377851,0.500893897969039,"PTGER1","prostaglandin E receptor 1",TRUE
+"214391_x_at",0.88020017258149,0.535564958366223,0.629335857599884,-5.74859504639097,0.174343222537934,"PTGER1","prostaglandin E receptor 1",TRUE
+"207650_x_at",0.963790340813952,0.834615112327722,0.211260414416981,-5.9179687340593,0.118868877593099,"PTGER1","prostaglandin E receptor 1",TRUE
+"206631_at",0.821990323055816,0.385325703158644,0.885634403429331,-5.56471085740811,1.21482665073211,"PTGER2","prostaglandin E receptor 2",TRUE
+"210832_x_at",0.406142422607459,0.0153449860793311,-2.62690425553317,-3.04287454926361,-2.59018861192683,"PTGER3","prostaglandin E receptor 3",TRUE
+"211909_x_at",0.497725944448536,0.0308052332163606,2.30654706677414,-3.63533155946128,1.05930022860665,"PTGER3","prostaglandin E receptor 3",TRUE
+"210831_s_at",0.603702127972549,0.0777178326078,-1.84985481042773,-4.39767486247672,-1.64362679011119,"PTGER3","prostaglandin E receptor 3",TRUE
+"210374_x_at",0.679876113745083,0.147154066549454,-1.50224052776304,-4.89650610559976,-1.11703470128819,"PTGER3","prostaglandin E receptor 3",TRUE
+"213933_at",0.779119049888702,0.300234388794434,-1.06074025270034,-5.40602835092198,-1.13674271011171,"PTGER3","prostaglandin E receptor 3",TRUE
+"208169_s_at",0.826134344333512,0.393941129941469,-0.869415226978731,-5.57807806209859,-0.758163239720724,"PTGER3","prostaglandin E receptor 3",TRUE
+"211265_at",0.852094603401457,0.457669917818321,0.755901683867575,-5.66514911770354,0.550928260914577,"PTGER3","prostaglandin E receptor 3",TRUE
+"210833_at",0.860662835518481,0.480179055941763,-0.718134209281907,-5.69157093679352,-0.866138305814716,"PTGER3","prostaglandin E receptor 3",TRUE
+"210375_at",0.867099100798202,0.498992200847694,-0.687353759596785,-5.71215124512956,-0.875147382521775,"PTGER3","prostaglandin E receptor 3",TRUE
+"210834_s_at",0.99176128617116,0.961955989678334,-0.0482415020290823,-5.93855003029189,-0.0496138340479515,"PTGER3","prostaglandin E receptor 3",TRUE
+"204896_s_at",0.736020435324742,0.22117071349434,1.2588955050948,-5.19591862712228,1.25003130086688,"PTGER4","prostaglandin E receptor 4",TRUE
+"204897_at",0.740476003158683,0.229604255593215,1.23544646319342,-5.22241168191578,1.22194477659454,"PTGER4","prostaglandin E receptor 4",TRUE
+"217158_at",0.978438107398701,0.896261833248269,-0.131889763147797,-5.93121461146669,-0.0738350656888169,"PTGER4P2-CDK2AP2P2","PTGER4P2-CDK2AP2P2 readthrough, transcribed pseudogene",TRUE
+"207388_s_at",0.42796179417767,0.0184784560451476,2.54298515081202,-3.20195986066345,2.15920901136654,"PTGES","prostaglandin E synthase",TRUE
+"210367_s_at",0.587626678796111,0.0664576765016141,1.93037942968536,-4.27138879827601,2.21826333259018,"PTGES","prostaglandin E synthase",TRUE
+"218083_at",0.786455312223125,0.312096720558048,-1.03442462927414,-5.43152951603255,-0.412780531107204,"PTGES2","prostaglandin E synthase 2",TRUE
+"200627_at",0.97979222603145,0.903519076400364,0.122612809678855,-5.93236367361465,0.0277350979144497,"PTGES3","prostaglandin E synthase 3",TRUE
+"238740_at",0.691814633378193,0.161378277463786,1.44887560189497,-4.96588349505936,0.469107060845367,"PTGES3L","prostaglandin E synthase 3 like",TRUE
+"222064_s_at",0.957017346544368,0.80520593487905,0.249587239177793,-5.90938793637039,0.0762153376350039,"PTGES3L-AARSD1///PTGES3L///AARSD1","PTGES3L-AARSD1 readthrough///prostaglandin E synthase 3 like///alanyl-tRNA synthetase domain containing 1",TRUE
+"207177_at",0.327864702134751,0.00761614080646823,2.935600228188,-2.43765973385493,2.23355252609392,"PTGFR","prostaglandin F receptor",TRUE
+"1555097_a_at",0.365381351431931,0.0107247246052125,2.78614236940689,-2.73433664247429,1.87323317920275,"PTGFR","prostaglandin F receptor",TRUE
+"224950_at",0.656641058207682,0.124674729314201,1.59590931021213,-4.76991468691987,1.30108272154249,"PTGFRN","prostaglandin F2 receptor inhibitor",TRUE
+"224937_at",0.756584150514497,0.251866336987053,1.17653696735969,-5.28706419099894,1.19886982248555,"PTGFRN","prostaglandin F2 receptor inhibitor",TRUE
+"1555620_a_at",0.830635993561085,0.403540513153524,0.851611668079889,-5.59248648088956,0.346961264746544,"PTGIR","prostaglandin I2 (prostacyclin) receptor (IP)",TRUE
+"206187_at",0.879419229950485,0.53353520881794,0.632497677057259,-5.7466884377123,0.445649694819256,"PTGIR","prostaglandin I2 (prostacyclin) receptor (IP)",TRUE
+"211892_s_at",0.580630437263151,0.0633024569016139,1.95509168203483,-4.23188586664229,1.19673867309401,"PTGIS","prostaglandin I2 (prostacyclin) synthase",TRUE
+"208131_s_at",0.591331966259927,0.0688097239989938,1.9126210150654,-4.29956182707367,2.44306574679814,"PTGIS","prostaglandin I2 (prostacyclin) synthase",TRUE
+"210702_s_at",0.715352956634026,0.191096123899511,1.34857974166882,-5.09069138564929,1.43493941312049,"PTGIS","prostaglandin I2 (prostacyclin) synthase",TRUE
+"228824_s_at",0.819807973515613,0.377794479372552,0.900007588042405,-5.55267376931227,0.582722395282897,"PTGR1","prostaglandin reductase 1",TRUE
+"231897_at",0.853093296743962,0.459496711355899,0.752795977738087,-5.66737026686809,0.449281215902369,"PTGR1","prostaglandin reductase 1",TRUE
+"228825_at",0.981944022360435,0.913527779837306,0.109836539574334,-5.93380922702229,0.0543597445912365,"PTGR1","prostaglandin reductase 1",TRUE
+"230774_at",0.85334340854827,0.460709724740107,-0.750737832841656,-5.66883744825827,-0.384097298855947,"PTGR2","prostaglandin reductase 2",TRUE
+"209944_at",0.660460734341314,0.128479908168056,-1.57912026783147,-4.79304754346817,-0.478060011434513,"PTGR2///ZNF410","prostaglandin reductase 2///zinc finger protein 410",TRUE
+"202010_s_at",0.740681080735184,0.230890407337208,-1.23192830918444,-5.22634954619467,-0.367558469351401,"PTGR2///ZNF410","prostaglandin reductase 2///zinc finger protein 410",TRUE
+"205127_at",0.487553723496951,0.0287923597515163,2.33833763740607,-3.57843206940595,1.45072475803238,"PTGS1","prostaglandin-endoperoxide synthase 1",TRUE
+"238669_at",0.816358096928248,0.367406819863032,0.920145568934555,-5.53550783638013,0.724265163781257,"PTGS1","prostaglandin-endoperoxide synthase 1",TRUE
+"205128_x_at",0.819203514175924,0.376076485659407,0.903312669161064,-5.54988052514706,0.655008260533507,"PTGS1","prostaglandin-endoperoxide synthase 1",TRUE
+"215813_s_at",0.950214160603623,0.774154849835098,0.290474243115417,-5.89867074249937,0.194839395648189,"PTGS1","prostaglandin-endoperoxide synthase 1",TRUE
+"204748_at",0.0808717557112272,0.000278712072196743,4.31060448051823,0.4702029214871,6.6697232296172,"PTGS2","prostaglandin-endoperoxide synthase 2",TRUE
+"1554997_a_at",0.0820586380687064,0.000288162021201493,4.29700417080541,0.440815853981339,6.43616737244609,"PTGS2","prostaglandin-endoperoxide synthase 2",TRUE
+"206977_at",0.634743115037769,0.105721545531976,1.68654883749101,-4.64177906318745,1.24856065403272,"PTH","parathyroid hormone",TRUE
+"205911_at",0.988303773451367,0.944306857409655,-0.0706541571374562,-5.93725234923813,-0.0264025844303735,"PTH1R","parathyroid hormone 1 receptor",TRUE
+"1555238_at",0.864894115958506,0.493468354472787,0.696321234904845,-5.70624419940287,0.242090757686114,"PTH2","parathyroid hormone 2",TRUE
+"206772_at",0.409937516868549,0.0158426698334384,2.61255801048376,-3.07025105497143,2.9480097769864,"PTH2R","parathyroid hormone 2 receptor",TRUE
+"210355_at",0.050114022740896,6.77045405088364e-05,4.8888963612186,1.71400313065784,4.67661992493589,"PTHLH","parathyroid hormone like hormone",TRUE
+"206300_s_at",0.204217046368216,0.00230191048860257,3.44318262595127,-1.39087430237881,3.74551859688665,"PTHLH","parathyroid hormone like hormone",TRUE
+"211756_at",0.341170383079786,0.00851755963244458,2.8870164023685,-2.53479370064796,4.38429095924004,"PTHLH","parathyroid hormone like hormone",TRUE
+"241453_at",0.767727587789514,0.269827390903856,1.13178117689344,-5.3343352554972,0.550793263393677,"PTK2","protein tyrosine kinase 2",TRUE
+"207821_s_at",0.79943091106207,0.333985992549622,0.987653355073637,-5.47542352856635,0.334192408455014,"PTK2","protein tyrosine kinase 2",TRUE
+"208820_at",0.85334340854827,0.46029579897161,0.751439784591246,-5.66833747812244,0.297810909683369,"PTK2","protein tyrosine kinase 2",TRUE
+"1559529_at",0.896428361916712,0.580802901056294,0.560439703889841,-5.78784765411123,0.284000477691986,"PTK2","protein tyrosine kinase 2",TRUE
+"203110_at",0.470885186348082,0.0254721337421209,2.39554490087226,-3.47493059710182,1.86051912130771,"PTK2B","protein tyrosine kinase 2 beta",TRUE
+"203111_s_at",0.995107941501942,0.976998524002272,0.0291593966612464,-5.93926935386548,0.0197382133791848,"PTK2B","protein tyrosine kinase 2 beta",TRUE
+"206482_at",0.941638390092674,0.738602725148869,0.337922072629234,-5.88421762897391,0.447413233697806,"PTK6","protein tyrosine kinase 6",TRUE
+"1553114_a_at",0.973499570783928,0.872507407403613,-0.162342730333093,-5.92685499966384,-0.133453024687984,"PTK6","protein tyrosine kinase 6",TRUE
+"207011_s_at",0.707818577910656,0.179451744534016,1.38628975058013,-5.04463363774761,1.5508578037243,"PTK7","protein tyrosine kinase 7 (inactive)",TRUE
+"1555324_at",0.769782310234542,0.277285774299343,1.11383916587241,-5.35283143751667,1.25712131400023,"PTK7","protein tyrosine kinase 7 (inactive)",TRUE
+"208549_x_at",0.937623890519979,0.723409927501958,-0.358435613662955,-5.87730051445229,-0.12016592563587,"PTMA","prothymosin, alpha",TRUE
+"200773_x_at",0.99177641642161,0.962083403926314,0.0480798046903256,-5.93855761540295,0.00979523909442115,"PTMA","prothymosin, alpha",TRUE
+"218044_x_at",0.734730148360473,0.219613134270325,1.26330078793664,-5.19089380877382,0.806745316433728,"PTMS","parathymosin",TRUE
+"218045_x_at",0.897300940949134,0.58347060689786,0.556464302162503,-5.78997822819399,0.218664749446829,"PTMS","parathymosin",TRUE
+"209465_x_at",0.57460012602512,0.0605865519256482,1.97724988350725,-4.19617442315489,2.65093332147712,"PTN","pleiotrophin",TRUE
+"211737_x_at",0.647754107214051,0.119022311020509,1.62165514589818,-4.73407173569826,1.31611818215243,"PTN","pleiotrophin",TRUE
+"208408_at",0.686108994812404,0.154865498033468,1.47281471067152,-4.93501209124755,0.878333627161548,"PTN","pleiotrophin",TRUE
+"209466_x_at",0.722173830067023,0.198417837682064,1.32578598615381,-5.11801510714635,0.538609180217088,"PTN","pleiotrophin",TRUE
+"212032_s_at",0.73957587762701,0.228204562538666,-1.23929226747911,-5.21809601022581,-0.429149927702991,"PTOV1","prostate tumor overexpressed 1",TRUE
+"235665_at",0.78187900363728,0.303445419885839,-1.05354510971732,-5.41305797101412,-0.423497378818277,"PTOV1","prostate tumor overexpressed 1",TRUE
+"240615_at",0.627092759817312,0.0985238723795672,-1.72460365187402,-4.58638549891923,-0.991916423293729,"PTOV1-AS1","PTOV1 antisense RNA 1",TRUE
+"233745_at",0.966313390701604,0.842913725870413,-0.20050624717464,-5.92012114964161,-0.0798558612581357,"PTOV1-AS1","PTOV1 antisense RNA 1",TRUE
+"213691_at",0.461228794465263,0.023147906941247,-2.43984835005698,-3.39382501248305,-1.33122051817807,"PTOV1-AS2","PTOV1 antisense RNA 2",TRUE
+"213690_s_at",0.96287357728432,0.831621001117175,-0.215146677698619,-5.91716337189092,-0.131943652815481,"PTOV1-AS2","PTOV1 antisense RNA 2",TRUE
+"212029_s_at",0.989475734766121,0.948082690032943,-0.0658565037514234,-5.9375712701977,-0.0474193105730452,"PTOV1-AS2","PTOV1 antisense RNA 2",TRUE
+"200732_s_at",0.92051722798026,0.66181406711306,-0.443346389979971,-5.84439910325929,-0.194734490641745,"PTP4A1","protein tyrosine phosphatase type IVA, member 1",TRUE
+"200731_s_at",0.947778780715578,0.761978819833498,-0.30664228818025,-5.89398866976529,-0.152664378691487,"PTP4A1","protein tyrosine phosphatase type IVA, member 1",TRUE
+"200730_s_at",0.957430653957785,0.807538136049948,0.246534635811059,-5.91012339385092,0.139445987156289,"PTP4A1","protein tyrosine phosphatase type IVA, member 1",TRUE
+"240329_at",0.986342822130003,0.93515424820224,0.0822909418569163,-5.9363857252369,0.0519769080913592,"PTP4A1","protein tyrosine phosphatase type IVA, member 1",TRUE
+"200733_s_at",0.9865209638456,0.937370838458944,0.0794717248625208,-5.93660777744645,0.0339261626931364,"PTP4A1","protein tyrosine phosphatase type IVA, member 1",TRUE
+"208617_s_at",0.701591887097885,0.173184333115251,-1.40739687390424,-5.01839472203642,-0.61290850822567,"PTP4A2","protein tyrosine phosphatase type IVA, member 2",TRUE
+"216988_s_at",0.760244814241272,0.258568766373262,-1.15956764149168,-5.30517660414873,-0.339544594011535,"PTP4A2","protein tyrosine phosphatase type IVA, member 2",TRUE
+"208616_s_at",0.769847953580141,0.27751280130626,-1.11329857813837,-5.35338466055393,-0.288113533537562,"PTP4A2","protein tyrosine phosphatase type IVA, member 2",TRUE
+"208615_s_at",0.900417564319563,0.595337813445856,-0.538888022092937,-5.79922149286235,-0.261941810999275,"PTP4A2","protein tyrosine phosphatase type IVA, member 2",TRUE
+"206574_s_at",0.910165867297668,0.626328617752843,-0.493768959151115,-5.82162633278039,-0.522969353856109,"PTP4A3","protein tyrosine phosphatase type IVA, member 3",TRUE
+"214223_at",0.956619372543067,0.803002516123857,0.25247350809422,-5.90868427948894,0.208694855443341,"PTP4A3","protein tyrosine phosphatase type IVA, member 3",TRUE
+"209695_at",0.956960361976289,0.804995804765847,-0.249862395786905,-5.90932120143886,-0.121363406947999,"PTP4A3","protein tyrosine phosphatase type IVA, member 3",TRUE
+"216105_x_at",0.0592928515268338,0.000125060828620295,-4.63765104215803,1.17555688759816,-1.47152212218549,"PTPA","protein phosphatase 2 phosphatase activator",TRUE
+"206452_x_at",0.0931719718255542,0.000374903224538124,-4.18964873409171,0.208821367536932,-1.38275946711349,"PTPA","protein phosphatase 2 phosphatase activator",TRUE
+"208874_x_at",0.0984173594430505,0.000432010356951662,-4.13177518753586,0.0837796571982139,-1.34926429624865,"PTPA","protein phosphatase 2 phosphatase activator",TRUE
+"238841_at",0.835952408568777,0.416627989657932,0.827769821606138,-5.61134592585468,0.274774306079324,"PTPDC1","protein tyrosine phosphatase domain containing 1",TRUE
+"229517_at",0.936143408699214,0.714838110893052,0.370078371999486,-5.87319555644268,0.253858336477992,"PTPDC1","protein tyrosine phosphatase domain containing 1",TRUE
+"229535_at",0.993474831312851,0.969150922228641,-0.0391125749958498,-5.93893840219555,-0.0129959756064739,"PTPMT1","protein tyrosine phosphatase, mitochondrial 1",TRUE
+"225901_at",0.997608949249317,0.988153843635282,0.0150159574290687,-5.9395736588492,0.00710946712847793,"PTPMT1","protein tyrosine phosphatase, mitochondrial 1",TRUE
+"218570_at",0.645803111489595,0.116996549362749,-1.63113150262047,-4.72076735257597,-0.653251259469858,"PTPMT1///KBTBD4","protein tyrosine phosphatase, mitochondrial 1///kelch repeat and BTB domain containing 4",TRUE
+"223808_s_at",0.912722788750542,0.633899427946782,-0.482906344923234,-5.826734939025,-0.196975398690238,"PTPMT1///NDUFS3","protein tyrosine phosphatase, mitochondrial 1///NADH:ubiquinone oxidoreductase core subunit S3",TRUE
+"239526_x_at",0.719675699464475,0.195579911494307,-1.33454142229666,-5.10756592056541,-0.850238816134884,"PTPN1","protein tyrosine phosphatase, non-receptor type 1",TRUE
+"202716_at",0.72713608277202,0.207346942092355,-1.29886085274515,-5.14978490770118,-0.591187421059264,"PTPN1","protein tyrosine phosphatase, non-receptor type 1",TRUE
+"217686_at",0.948684674264832,0.766753374610296,-0.30029265058247,-5.89585742380993,-0.182151216478194,"PTPN1","protein tyrosine phosphatase, non-receptor type 1",TRUE
+"217689_at",0.95238233774064,0.782251792768613,-0.279766518562508,-5.90163312648164,-0.152658423595472,"PTPN1","protein tyrosine phosphatase, non-receptor type 1",TRUE
+"1552637_at",0.665892433917011,0.132988023322166,-1.55975597559459,-4.81949061577126,-1.24118506356627,"PTPN11","protein tyrosine phosphatase, non-receptor type 11",TRUE
+"205867_at",0.792305111661886,0.323267665670391,1.01027954598363,-5.45441887416318,0.445983987948599,"PTPN11","protein tyrosine phosphatase, non-receptor type 11",TRUE
+"212610_at",0.856257656023992,0.469881903595722,-0.735278655886305,-5.67973606082382,-0.178722301177674,"PTPN11","protein tyrosine phosphatase, non-receptor type 11",TRUE
+"205868_s_at",0.908367146600979,0.619122384288934,0.504164710832811,-5.81663337299756,0.218857861700288,"PTPN11","protein tyrosine phosphatase, non-receptor type 11",TRUE
+"209895_at",0.943464796017993,0.746795947700719,-0.326921087497143,-5.88776109016529,-0.0854841192837164,"PTPN11","protein tyrosine phosphatase, non-receptor type 11",TRUE
+"209896_s_at",0.954672574687803,0.793529883316625,-0.264907097198415,-5.90556113361671,-0.0819639251918787,"PTPN11","protein tyrosine phosphatase, non-receptor type 11",TRUE
+"202006_at",0.731548533938014,0.214990170013616,1.27651868896851,-5.1757269686776,0.399443954494425,"PTPN12","protein tyrosine phosphatase, non-receptor type 12",TRUE
+"216915_s_at",0.753862100951903,0.247147120045053,1.18868805120385,-5.2739533459009,0.514612581224011,"PTPN12","protein tyrosine phosphatase, non-receptor type 12",TRUE
+"216884_at",0.852409445602775,0.458250783318249,0.754913358219687,-5.66585689053675,0.574865349433564,"PTPN12","protein tyrosine phosphatase, non-receptor type 12",TRUE
+"243792_x_at",0.776955214137673,0.295512390271173,1.07142142607753,-5.39551385468181,0.598669711379499,"PTPN13","protein tyrosine phosphatase, non-receptor type 13",TRUE
+"204201_s_at",0.810602600845179,0.354760226455779,0.945181808351202,-5.51367924790342,0.565793653472575,"PTPN13","protein tyrosine phosphatase, non-receptor type 13",TRUE
+"244533_at",0.687659256779784,0.156659993479205,1.46613852911427,-4.94366280290624,1.32178887665476,"PTPN14","protein tyrosine phosphatase, non-receptor type 14",TRUE
+"205503_at",0.724970327905974,0.202600176320483,1.3130594564634,-5.13310019214799,0.677584591141377,"PTPN14","protein tyrosine phosphatase, non-receptor type 14",TRUE
+"226282_at",0.85334340854827,0.461384528755712,0.749594280967016,-5.66965100361473,0.700155799655448,"PTPN14","protein tyrosine phosphatase, non-receptor type 14",TRUE
+"242321_at",0.892746695408886,0.565313571307723,0.583705982388134,-5.77508363823148,0.611096614721125,"PTPN14","protein tyrosine phosphatase, non-receptor type 14",TRUE
+"1569552_at",0.819018525257656,0.374870729015547,0.905638259628473,-5.5479094141434,0.408621299067274,"PTPN18","protein tyrosine phosphatase, non-receptor type 18",TRUE
+"213521_at",0.937462538530338,0.722351758081754,0.359870121841604,-5.87680173924412,0.121138386798851,"PTPN18","protein tyrosine phosphatase, non-receptor type 18",TRUE
+"203555_at",0.983661414460339,0.920286568924966,0.101219551666301,-5.93469455703675,0.0299723676830634,"PTPN18","protein tyrosine phosphatase, non-receptor type 18",TRUE
+"213137_s_at",0.201203203991061,0.00225951106082325,3.45093323605332,-1.37452918654651,1.35051593910838,"PTPN2","protein tyrosine phosphatase, non-receptor type 2",TRUE
+"213136_at",0.231131606308726,0.00294225144930724,3.34054136164898,-1.60648583223947,1.23478711006099,"PTPN2","protein tyrosine phosphatase, non-receptor type 2",TRUE
+"243410_at",0.305949355810268,0.00610805832531112,3.03076922157245,-2.24560004588704,1.60316298729138,"PTPN2","protein tyrosine phosphatase, non-receptor type 2",TRUE
+"204935_at",0.435020772526436,0.0197881708034783,2.51180513975538,-3.26040144254763,1.46694855115524,"PTPN2","protein tyrosine phosphatase, non-receptor type 2",TRUE
+"241623_at",0.595019326272843,0.0718420974756762,1.8904961162543,-4.33440859020658,0.8082471521382,"PTPN2","protein tyrosine phosphatase, non-receptor type 2",TRUE
+"241983_at",0.722442821599878,0.198973617231964,1.32408280235597,-5.12004104586601,0.517468944203723,"PTPN2","protein tyrosine phosphatase, non-receptor type 2",TRUE
+"241622_at",0.877488742289724,0.527563553862016,-0.641837895176301,-5.7410025311001,-0.37410464316888,"PTPN2","protein tyrosine phosphatase, non-receptor type 2",TRUE
+"215172_at",0.370281512376054,0.0111418183340152,2.76932896423946,-2.76730062414599,5.6369836269585,"PTPN20","protein tyrosine phosphatase, non-receptor type 20",TRUE
+"222092_at",0.6708432030569,0.136694836360302,1.54423643302214,-4.84049788573297,0.724809195686255,"PTPN21","protein tyrosine phosphatase, non-receptor type 21",TRUE
+"1320_at",0.921729477898827,0.666210727592047,-0.437182135435288,-5.8470183006514,-0.397746275687759,"PTPN21","protein tyrosine phosphatase, non-receptor type 21",TRUE
+"40524_at",0.952041062962677,0.780507303267061,0.282070636884922,-5.90100499390089,0.234834264541791,"PTPN21","protein tyrosine phosphatase, non-receptor type 21",TRUE
+"205438_at",0.969450447163359,0.854541034625084,0.185478716648357,-5.92294124011722,0.18843226056313,"PTPN21","protein tyrosine phosphatase, non-receptor type 21",TRUE
+"226380_at",0.998982279127329,0.996687649848692,-0.00419851862598873,-5.93967489501885,-0.00347597359620799,"PTPN21","protein tyrosine phosphatase, non-receptor type 21",TRUE
+"206060_s_at",0.851733415458562,0.456572020118738,-0.757771782631006,-5.66380748053833,-0.477099235382128,"PTPN22","protein tyrosine phosphatase, non-receptor type 22",TRUE
+"208010_s_at",0.956619372543067,0.803132343711085,-0.252303385769668,-5.90872597741206,-0.176416804565365,"PTPN22","protein tyrosine phosphatase, non-receptor type 22",TRUE
+"208011_at",0.957504800422796,0.808253606533337,0.24559864213389,-5.91034709853654,0.224083112925059,"PTPN22","protein tyrosine phosphatase, non-receptor type 22",TRUE
+"236539_at",0.998709719538178,0.994356366486422,-0.00715354289189162,-5.93965855621259,-0.00929248413581529,"PTPN22","protein tyrosine phosphatase, non-receptor type 22",TRUE
+"223150_s_at",0.783844746433788,0.306465863636986,-1.04682622399085,-5.41958349363553,-0.302641430678451,"PTPN23","protein tyrosine phosphatase, non-receptor type 23",TRUE
+"223149_s_at",0.92346045063848,0.671429330318893,0.429887744587093,-5.8500711781927,0.229228144078246,"PTPN23","protein tyrosine phosphatase, non-receptor type 23",TRUE
+"227944_at",0.713633547141264,0.188677414483489,1.35626029914534,-5.0813965315653,0.715938875700832,"PTPN3","protein tyrosine phosphatase, non-receptor type 3",TRUE
+"203997_at",0.812302873476553,0.358294783155839,0.93812500317356,-5.51988641462016,0.551544749055509,"PTPN3","protein tyrosine phosphatase, non-receptor type 3",TRUE
+"230230_at",0.791288352788084,0.321725470187089,-1.01357778436157,-5.45132099638491,-0.339737566603563,"PTPN4","protein tyrosine phosphatase, non-receptor type 4",TRUE
+"236935_at",0.835952408568777,0.416314248847648,0.828335776520518,-5.61090404321637,0.285849400421152,"PTPN4","protein tyrosine phosphatase, non-receptor type 4",TRUE
+"232161_x_at",0.925389506721126,0.676700696748989,0.422543591752609,-5.85309389917892,0.375329984737521,"PTPN4","protein tyrosine phosphatase, non-receptor type 4",TRUE
+"205171_at",0.961212424803935,0.824294697979614,0.224670432208235,-5.91512795282951,0.0730655240380784,"PTPN4","protein tyrosine phosphatase, non-receptor type 4",TRUE
+"233471_at",0.805746717966166,0.345617158448896,0.96365937619946,-5.49722457415469,0.568031631312393,"PTPN5","protein tyrosine phosphatase, non-receptor type 5",TRUE
+"236456_at",0.841391443291102,0.431997086752484,0.800366384671198,-5.63240292737132,0.592760395558162,"PTPN5","protein tyrosine phosphatase, non-receptor type 5",TRUE
+"233470_at",0.958574217853323,0.812127570542325,0.240534509432524,-5.91154276558146,0.0805451064468521,"PTPN5","protein tyrosine phosphatase, non-receptor type 5",TRUE
+"206687_s_at",0.905462783815257,0.611632940263234,0.515029036272208,-5.81130692198129,0.198024003989302,"PTPN6","protein tyrosine phosphatase, non-receptor type 6",TRUE
+"1554860_at",0.86219003266709,0.485128999878189,0.709969104092647,-5.69711396657634,0.191539869839502,"PTPN7","protein tyrosine phosphatase, non-receptor type 7",TRUE
+"204852_s_at",0.925549026820891,0.678331224292755,0.420276709701873,-5.85401656775656,0.27668791898185,"PTPN7","protein tyrosine phosphatase, non-receptor type 7",TRUE
+"233226_at",0.841813886364358,0.434111409288472,0.796644258139246,-5.63521168681811,0.335135628511137,"PTPN9","protein tyrosine phosphatase, non-receptor type 9",TRUE
+"230140_at",0.974670398319743,0.876106245979525,-0.157719664900317,-5.927574803311,-0.0970347964600489,"PTPN9","protein tyrosine phosphatase, non-receptor type 9",TRUE
+"202958_at",0.991601758274444,0.960389199957291,-0.0502299737806779,-5.93845467070382,-0.0159689839994179,"PTPN9","protein tyrosine phosphatase, non-receptor type 9",TRUE
+"213795_s_at",0.714813484380156,0.19052031917536,-1.35040122627019,-5.08849105657128,-0.475489537757223,"PTPRA","protein tyrosine phosphatase, receptor type A",TRUE
+"239419_at",0.760244814241272,0.258601427622482,1.15948575290566,-5.3052634497338,0.704598219459712,"PTPRA","protein tyrosine phosphatase, receptor type A",TRUE
+"213799_s_at",0.819018525257656,0.375183209319754,-0.905035092958468,-5.54842109243875,-0.370757049704956,"PTPRA","protein tyrosine phosphatase, receptor type A",TRUE
+"230250_at",0.108170248720888,0.000508454575606184,4.06522784545116,-0.0599354845309028,3.13613124066199,"PTPRB","protein tyrosine phosphatase, receptor type B",TRUE
+"217177_s_at",0.281385315744461,0.0047362318910667,3.13948186125705,-2.02355480015693,1.56042498313623,"PTPRB","protein tyrosine phosphatase, receptor type B",TRUE
+"205846_at",0.327864702134751,0.00774250375720351,2.9284681796409,-2.45195885513416,2.66838055528377,"PTPRB","protein tyrosine phosphatase, receptor type B",TRUE
+"1560105_at",0.539440741338063,0.0442405538940992,-2.13304592435653,-3.93761116720707,-1.17501368857639,"PTPRB","protein tyrosine phosphatase, receptor type B",TRUE
+"207238_s_at",0.723655063748891,0.200458757153109,1.31954975458702,-5.12542241239972,0.683571854500845,"PTPRC","protein tyrosine phosphatase, receptor type C",TRUE
+"1552480_s_at",0.920148132387211,0.66016736697125,0.445659601500487,-5.84340693214058,0.479575842460633,"PTPRC","protein tyrosine phosphatase, receptor type C",TRUE
+"212588_at",0.925091998149497,0.67583318941262,0.423750583071081,-5.85260063808787,0.311703640981188,"PTPRC","protein tyrosine phosphatase, receptor type C",TRUE
+"1569830_at",0.944785393058556,0.751563099487093,-0.320539239008746,-5.88976351304018,-0.264069598593941,"PTPRC","protein tyrosine phosphatase, receptor type C",TRUE
+"212587_s_at",0.97333911557514,0.871118480885932,-0.164127907820787,-5.92657149949727,-0.14098540131909,"PTPRC","protein tyrosine phosphatase, receptor type C",TRUE
+"204960_at",0.990810941805126,0.954054784611985,-0.0582714199638875,-5.9380297647754,-0.0487538936059151,"PTPRCAP","protein tyrosine phosphatase, receptor type C associated protein",TRUE
+"205712_at",0.468735421183467,0.0250264075973627,-2.40374287647173,-3.45998424374774,-1.92593086997428,"PTPRD","protein tyrosine phosphatase, receptor type D",TRUE
+"242493_at",0.912141993216912,0.631659182481959,0.486114460878292,-5.82523774274109,0.431180077589984,"PTPRD","protein tyrosine phosphatase, receptor type D",TRUE
+"214043_at",0.916107385524794,0.646266047376175,0.46528790496431,-5.83478438058668,0.50431089757173,"PTPRD","protein tyrosine phosphatase, receptor type D",TRUE
+"213362_at",0.948567563026335,0.766058563839348,0.301215883772385,-5.8955881161793,0.264509657666369,"PTPRD","protein tyrosine phosphatase, receptor type D",TRUE
+"1560425_s_at",0.925091998149497,0.675593716776262,0.424083881854551,-5.8524641852378,0.481764041516523,"PTPRD-AS1","PTPRD antisense RNA 1",TRUE
+"221840_at",0.598790786356002,0.0757748115819513,1.86298845811282,-4.37733603958617,1.60664304571017,"PTPRE","protein tyrosine phosphatase, receptor type E",TRUE
+"1559018_at",0.813065886130395,0.362637472205545,0.929518519078739,-5.52739884156639,0.593466153269638,"PTPRE","protein tyrosine phosphatase, receptor type E",TRUE
+"233978_at",0.907964244160782,0.617755961278217,-0.506142250953645,-5.81567209054419,-0.368601771877826,"PTPRE","protein tyrosine phosphatase, receptor type E",TRUE
+"200637_s_at",0.874480604680453,0.520818734318017,0.65245701506805,-5.73444082377295,0.254933497600277,"PTPRF","protein tyrosine phosphatase, receptor type F",TRUE
+"200636_s_at",0.901290587245706,0.597959117727494,-0.535028899232896,-5.80121237573798,-0.166816301267996,"PTPRF","protein tyrosine phosphatase, receptor type F",TRUE
+"200635_s_at",0.936143408699214,0.715241414785729,-0.369529423304038,-5.87339201191451,-0.138405454667641,"PTPRF","protein tyrosine phosphatase, receptor type F",TRUE
+"215066_at",0.986342822130003,0.93426168434375,-0.0834263596951411,-5.93629411054574,-0.0456269888513212,"PTPRF","protein tyrosine phosphatase, receptor type F",TRUE
+"227126_at",0.860714927752408,0.48032081854911,-0.717899688003378,-5.69173098718425,-1.25328611981465,"PTPRG","protein tyrosine phosphatase, receptor type G",TRUE
+"1569323_at",0.90344422113846,0.603864045779229,0.526365492628155,-5.80563102837017,0.474089729972758,"PTPRG","protein tyrosine phosphatase, receptor type G",TRUE
+"204944_at",0.96479405380661,0.83700583689129,-0.208159718970513,-5.91860081670762,-0.427314672940568,"PTPRG","protein tyrosine phosphatase, receptor type G",TRUE
+"244574_at",0.979616296735197,0.903118342197748,-0.123124774276063,-5.93230244127474,-0.0877205801744267,"PTPRG","protein tyrosine phosphatase, receptor type G",TRUE
+"232242_at",0.96350209729653,0.833570263513752,-0.212616214578182,-5.91768942755684,-0.203003855282446,"PTPRG-AS1","PTPRG antisense RNA 1",TRUE
+"208300_at",0.615964925929095,0.087098407879992,1.79019762422398,-4.48875913486501,1.48886909526173,"PTPRH","protein tyrosine phosphatase, receptor type H",TRUE
+"227396_at",0.821424121108148,0.382940162766458,-0.890167072986797,-5.56093425855037,-0.561412923468271,"PTPRJ","protein tyrosine phosphatase, receptor type J",TRUE
+"210173_at",0.955841603889187,0.798964274744803,-0.257768934417207,-5.90737237547206,-0.219900616370728,"PTPRJ","protein tyrosine phosphatase, receptor type J",TRUE
+"214137_at",0.986889306520757,0.938847562717938,0.0775938896913436,-5.9367513907728,0.021423931373648,"PTPRJ","protein tyrosine phosphatase, receptor type J",TRUE
+"203038_at",0.624520459874487,0.0960919490865433,1.73799773188546,-4.56666930259639,0.794966511928223,"PTPRK","protein tyrosine phosphatase, receptor type K",TRUE
+"233609_at",0.68747436517451,0.156131265461657,1.46809911985093,-4.94112565219712,0.883663392122023,"PTPRK","protein tyrosine phosphatase, receptor type K",TRUE
+"1555579_s_at",0.979329597087865,0.900087637553952,0.126997802726584,-5.93183096322874,0.264766997609112,"PTPRM","protein tyrosine phosphatase, receptor type M",TRUE
+"203329_at",0.980264692225439,0.908004040677655,0.116885225946732,-5.93303133830373,0.145150677094065,"PTPRM","protein tyrosine phosphatase, receptor type M",TRUE
+"204945_at",0.970526265934304,0.859266215363562,0.179384399488991,-5.92402253439472,0.0549979034615493,"PTPRN","protein tyrosine phosphatase, receptor type N",TRUE
+"203029_s_at",0.819479221404744,0.37680780693599,-0.901904537187606,-5.55107174563735,-1.01397876820601,"PTPRN2","protein tyrosine phosphatase, receptor type N2",TRUE
+"203030_s_at",0.905306717560218,0.611001759646071,0.515947495339451,-5.81085155390512,0.35146055550247,"PTPRN2","protein tyrosine phosphatase, receptor type N2",TRUE
+"211534_x_at",0.985361089461736,0.927407881266601,-0.0921488453501913,-5.93554847429859,-0.0709834938778497,"PTPRN2","protein tyrosine phosphatase, receptor type N2",TRUE
+"1554199_at",0.280730626658382,0.00471350187969628,3.14152850697635,-2.01934937734974,2.09889486566797,"PTPRO","protein tyrosine phosphatase, receptor type O",TRUE
+"211600_at",0.689643135449002,0.158526473275227,-1.45925996413094,-4.95254244070321,-0.742352258387347,"PTPRO","protein tyrosine phosphatase, receptor type O",TRUE
+"208121_s_at",0.812302873476553,0.360625941686338,0.933496391994706,-5.52393454412779,0.620105429171645,"PTPRO","protein tyrosine phosphatase, receptor type O",TRUE
+"206084_at",0.147189326785666,0.00101881285148386,3.78046074738442,-0.673012104528694,3.77795850269485,"PTPRR","protein tyrosine phosphatase, receptor type R",TRUE
+"210675_s_at",0.175233958083293,0.00156404520429167,3.60368937528829,-1.05078446300078,3.43709393361784,"PTPRR","protein tyrosine phosphatase, receptor type R",TRUE
+"210823_s_at",0.843753336849204,0.439461614512205,-0.787275248603928,-5.6422271162097,-0.856666958598069,"PTPRS","protein tyrosine phosphatase, receptor type S",TRUE
+"1555666_at",0.889836117464942,0.55811214906234,-0.594634111479748,-5.76891501906894,-0.493660548747307,"PTPRS","protein tyrosine phosphatase, receptor type S",TRUE
+"226571_s_at",0.978316880841318,0.895695744907158,-0.132613883249505,-5.93112140167587,-0.0546211137299419,"PTPRS","protein tyrosine phosphatase, receptor type S",TRUE
+"229465_s_at",0.993213867476782,0.967618956854809,-0.0410560196012044,-5.93886252207009,-0.0263240366949216,"PTPRS","protein tyrosine phosphatase, receptor type S",TRUE
+"205948_at",0.914242258486146,0.639492387443704,0.474919308537743,-5.83042029311118,0.367467488399158,"PTPRT","protein tyrosine phosphatase, receptor type T",TRUE
+"211320_s_at",0.95877806139143,0.813189242509763,-0.239147795538764,-5.91186585531295,-0.120555064282271,"PTPRU","protein tyrosine phosphatase, receptor type U",TRUE
+"204469_at",0.308861881799719,0.00641834007437369,3.00947207822723,-2.28877673470845,2.5102942564403,"PTPRZ1","protein tyrosine phosphatase, receptor type Z1",TRUE
+"208790_s_at",0.42796179417767,0.0184871308325595,2.54277192734203,-3.20236076492691,3.61236122168837,"PTRF","polymerase I and transcript release factor",TRUE
+"1557938_s_at",0.506191505604384,0.0332185445022506,2.27085245628649,-3.69867756041288,2.75842885680164,"PTRF","polymerase I and transcript release factor",TRUE
+"208789_at",0.536422380101288,0.0432777146279538,2.14376040774642,-3.91936617494413,4.24495045081078,"PTRF","polymerase I and transcript release factor",TRUE
+"1569430_at",0.90115698600215,0.597655644515279,-0.535475255294865,-5.80098281684245,-0.305932169364463,"PTRH1","peptidyl-tRNA hydrolase 1 homolog",TRUE
+"228014_at",0.937113154905832,0.720100385040669,-0.362924763787691,-5.8757330924905,-0.137971538418646,"PTRH1","peptidyl-tRNA hydrolase 1 homolog",TRUE
+"218732_at",0.900692252557887,0.595940749093307,-0.537999639988557,-5.79968103322538,-0.243436958092278,"PTRH2","peptidyl-tRNA hydrolase 2",TRUE
+"226243_at",0.899998627338565,0.594285613557742,-0.540439414718303,-5.79841722410749,-0.182471620845305,"PTRHD1","peptidyl-tRNA hydrolase domain containing 1",TRUE
+"209694_at",0.67565343307767,0.142233352026392,1.52168211895613,-4.87073054217525,0.499679076623327,"PTS","6-pyruvoyltetrahydropterin synthase",TRUE
+"203554_x_at",0.744573608322482,0.235909487782036,1.21833964463068,-5.24146823558717,0.39851481876425,"PTTG1","pituitary tumor-transforming 1",TRUE
+"200677_at",0.741068552355961,0.231286580290848,1.23084761273466,-5.22755722359279,0.512725749564321,"PTTG1IP","pituitary tumor-transforming 1 interacting protein",TRUE
+"214557_at",0.895690630367785,0.576327783558341,0.567129100485827,-5.7842293421712,0.376249776159397,"PTTG2","pituitary tumor-transforming 2",TRUE
+"208511_at",0.835952408568777,0.416940713209951,0.827205969077452,-5.61178588594195,0.371426618383436,"PTTG3P","pituitary tumor-transforming 3, pseudogene",TRUE
+"206157_at",0.610198729812125,0.0827214080542747,1.81730315486062,-4.44764107049609,3.52626469462863,"PTX3","pentraxin 3",TRUE
+"203974_at",0.894729774938685,0.571946236610251,-0.573704053774875,-5.78063238321996,-0.302799265455842,"PUDP","pseudouridine 5'-phosphatase",TRUE
+"209899_s_at",0.89967769475675,0.591070172050831,0.545188699023783,-5.79594114282419,0.228294401302067,"PUF60","poly(U) binding splicing factor 60",TRUE
+"201164_s_at",0.896907177224677,0.581925819981874,0.558765226899896,-5.78874686604275,0.137569583103254,"PUM1","pumilio RNA binding family member 1",TRUE
+"201165_s_at",0.900750978800947,0.596338777222757,-0.537413414292346,-5.79998387098526,-0.128506174363766,"PUM1","pumilio RNA binding family member 1",TRUE
+"201166_s_at",0.953983577550391,0.788097027587031,0.272057327302636,-5.90369757118728,0.0596771400315959,"PUM1","pumilio RNA binding family member 1",TRUE
+"216221_s_at",0.830635993561085,0.404402936093737,-0.850025541436849,-5.59375666022617,-0.262730711143739,"PUM2","pumilio RNA binding family member 2",TRUE
+"201493_s_at",0.862634144901168,0.485833181053131,-0.708811464941534,-5.6978949656796,-0.183384213060624,"PUM2","pumilio RNA binding family member 2",TRUE
+"235995_at",0.977930820766623,0.893507711959701,-0.135413423818506,-5.93075624838095,-0.0598475723870666,"PUM2","pumilio RNA binding family member 2",TRUE
+"1570529_at",0.823741997583852,0.390853150069586,0.875201827478235,-5.57333529078397,0.247081140596398,"PUM3","pumilio RNA binding family member 3",TRUE
+"203712_at",0.920867548532508,0.663529861384996,0.44093872947852,-5.8454264038929,0.247161301804008,"PUM3","pumilio RNA binding family member 3",TRUE
+"241685_x_at",0.62110896023334,0.0917434976145628,-1.76268758389557,-4.530030014065,-1.54880846725141,"PURA","purine rich element binding protein A",TRUE
+"229167_at",0.668193690220211,0.13427325366486,-1.55433500743107,-4.82684727907226,-0.488828784118491,"PURA","purine rich element binding protein A",TRUE
+"204021_s_at",0.690823350461169,0.160493910210503,-1.45207990800816,-4.96177510588262,-0.398564062700352,"PURA","purine rich element binding protein A",TRUE
+"204020_at",0.805609373521898,0.344905426893472,-0.965111606024712,-5.49591898335094,-0.271069228324986,"PURA","purine rich element binding protein A",TRUE
+"213806_at",0.9802233499944,0.907240066579545,-0.11786058094319,-5.93291989409226,-0.0597085548681244,"PURA","purine rich element binding protein A",TRUE
+"228467_at",0.581128536542197,0.0636484415717478,-1.95232950667497,-4.23631832912584,-1.02061832000579,"PURB","purine rich element binding protein B",TRUE
+"220860_at",0.94034618356165,0.733362414439681,0.344980477898425,-5.88188301097046,0.324500039142372,"PURG","purine rich element binding protein G",TRUE
+"235634_at",0.961539013416204,0.82557360968545,0.22300641738331,-5.91548991183202,0.0774961331329997,"PURG","purine rich element binding protein G",TRUE
+"218670_at",0.955925931146022,0.800900299185057,0.255229256580913,-5.9080049393821,0.0843313203395937,"PUS1","pseudouridylate synthase 1",TRUE
+"1553280_at",0.789378278298554,0.315871445945116,1.02619907596164,-5.4393821120433,0.430822363995946,"PUS10","pseudouridylate synthase 10",TRUE
+"232945_at",0.837067957688307,0.419526018161755,0.822554734854486,-5.61540442127195,0.634452800081522,"PUS10","pseudouridylate synthase 10",TRUE
+"229362_at",0.885312914741353,0.546612274780203,0.61223858345099,-5.75874541286558,0.281556901461557,"PUS10","pseudouridylate synthase 10",TRUE
+"221277_s_at",0.986342822130003,0.933729572869094,-0.0841033045326682,-5.93623889219903,-0.035715818927045,"PUS3","pseudouridylate synthase 3",TRUE
+"218984_at",0.946416600885596,0.757748520733345,0.312278887008659,-5.89229730611642,0.123159589870994,"PUS7","pseudouridylate synthase 7 (putative)",TRUE
+"229751_s_at",0.536559328842429,0.0434672917961717,-2.14163390349901,-3.92299183898662,-0.671501326082549,"PUS7L","pseudouridylate synthase 7 like",TRUE
+"221025_x_at",0.995810088048184,0.979805832960297,-0.0255996500336454,-5.93936429282417,-0.0080186684446808,"PUS7L","pseudouridylate synthase 7 like",TRUE
+"228733_at",0.964685626382167,0.83657016436045,-0.208724616264717,-5.91848635461548,-0.0687430590718137,"PUSL1","pseudouridylate synthase-like 1",TRUE
+"205336_at",0.758920166935337,0.256113527880098,-1.16574551262762,-5.29860925941998,-1.28593376674267,"PVALB","parvalbumin",TRUE
+"216283_s_at",0.547195868806649,0.047655625035749,-2.09666455132487,-3.99912890592044,-1.33936584833186,"PVR","poliovirus receptor",TRUE
+"239918_at",0.662855903464759,0.13071739250799,1.56944012171202,-4.80629835979102,0.8397590922534,"PVR","poliovirus receptor",TRUE
+"214444_s_at",0.794620886196317,0.326618778296182,1.00315022788339,-5.46108383856152,0.50540784304269,"PVR","poliovirus receptor",TRUE
+"214443_at",0.912882225913702,0.634551239064477,0.481973892870777,-5.82716828727094,0.265866450939068,"PVR","poliovirus receptor",TRUE
+"32699_s_at",0.969882914559333,0.856182636959854,-0.183360651729181,-5.92332112354797,-0.0734239456905179,"PVR","poliovirus receptor",TRUE
+"1556582_at",0.97928472590149,0.899729089120643,0.127456132992707,-5.93177420429205,0.044442112104317,"PVR","poliovirus receptor",TRUE
+"212662_at",0.994304286761558,0.97409475974111,-0.0328418582313805,-5.93915815412564,-0.0176170242319653,"PVR","poliovirus receptor",TRUE
+"219812_at",0.618124814816155,0.0890860422336057,1.77827518365737,-4.50670270132029,0.621851731673946,"PVRIG","poliovirus receptor related immunoglobulin domain containing",TRUE
+"236323_at",0.97928472590149,0.899495664276734,0.1277545335631,-5.93173714108502,0.0923369526473641,"PVRL3-AS1","PVRL3 antisense RNA 1",TRUE
+"216249_at",0.898098183774511,0.587053150249973,0.551139823431256,-5.79280876121859,0.226149753469869,"PVT1","Pvt1 oncogene (non-protein coding)",TRUE
+"214834_at",0.841346844002252,0.431597807297579,0.801070554634972,-5.63187016827374,0.76034608679111,"PWAR5","Prader Willi/Angelman region RNA 5",TRUE
+"226587_at",0.863525751448771,0.488350715516396,0.704680672896136,-5.70067189931016,1.00429676985379,"PWAR6","Prader Willi/Angelman region RNA 6",TRUE
+"226591_at",0.925389506721126,0.676840723331975,0.422348828044663,-5.85317336367413,0.749020894144262,"PWAR6","Prader Willi/Angelman region RNA 6",TRUE
+"201608_s_at",0.810375880424165,0.35438177575469,0.945940196297722,-5.51300963061987,0.245225119081532,"PWP1","PWP1 homolog, endonuclein",TRUE
+"201606_s_at",0.900750978800947,0.596264989055374,0.537522076942068,-5.79992776129467,0.142797099016342,"PWP1","PWP1 homolog, endonuclein",TRUE
+"201607_at",0.919232232113365,0.655996401144934,-0.451529895093888,-5.84086634235721,-0.112879683518258,"PWP1","PWP1 homolog, endonuclein",TRUE
+"1565603_at",0.812300464082654,0.356576511213481,0.941549678276804,-5.51687940099648,0.310691059777388,"PWP2","PWP2 periodic tryptophan protein homolog (yeast)",TRUE
+"209336_at",0.849935057946582,0.451953203175301,0.765669001861242,-5.65810733051324,0.243260844727548,"PWP2","PWP2 periodic tryptophan protein homolog (yeast)",TRUE
+"1565604_at",0.867159108376357,0.499167424211768,0.687070227210114,-5.71233682067115,0.32161579184049,"PWP2","PWP2 periodic tryptophan protein homolog (yeast)",TRUE
+"1568662_at",0.913160385122315,0.635568825110426,-0.480519045096844,-5.82784277812551,-0.419129749104985,"PWRN2","Prader-Willi region non-protein coding RNA 2",TRUE
+"1568663_a_at",0.913160385122315,0.635580214307032,0.480502767863861,-5.82785031323314,0.151768215947255,"PWRN2","Prader-Willi region non-protein coding RNA 2",TRUE
+"228337_at",0.875938621758472,0.52435971321403,-0.646872726938695,-5.73790432667152,-0.227456845624226,"PWWP2A","PWWP domain containing 2A",TRUE
+"217533_x_at",0.915353407558177,0.64271871748954,-0.470326190641094,-5.83251239878567,-0.340826820828353,"PWWP2A","PWWP domain containing 2A",TRUE
+"226720_at",0.965255754814725,0.8382145035729,-0.206592911920086,-5.9189166737211,-0.060004872814492,"PWWP2A","PWWP domain containing 2A",TRUE
+"228336_at",0.978951900396372,0.897661416544872,0.130099775014208,-5.93144283492139,0.0348151248830568,"PWWP2A","PWWP domain containing 2A",TRUE
+"238051_x_at",0.92346045063848,0.671546182302441,0.429724685274399,-5.85013884593361,0.20766264705065,"PWWP2B","PWWP domain containing 2B",TRUE
+"227999_at",0.966593471043185,0.844422130767281,0.198554139743544,-5.9204998492865,0.09992373650541,"PWWP2B","PWWP domain containing 2B",TRUE
+"238046_x_at",0.993516281527979,0.969606488890292,-0.0385346752380567,-5.93896025626389,-0.0210380221636708,"PWWP2B","PWWP domain containing 2B",TRUE
+"212923_s_at",0.468735421183467,0.0249484818345745,2.40518996553511,-3.45734301876041,2.72324459868747,"PXDC1","PX domain containing 1",TRUE
+"231387_at",0.971735822349954,0.864833558289928,-0.172212794084888,-5.92524884440022,-0.105329077198355,"PXDC1","PX domain containing 1",TRUE
+"212013_at",0.55937703282623,0.0535518514328499,2.03902867210731,-4.09518431248643,2.58966767206627,"PXDN","peroxidasin",TRUE
+"212012_at",0.593339168375633,0.0705124163664374,1.9000950002091,-4.3193250664606,2.34711325716512,"PXDN","peroxidasin",TRUE
+"241942_at",0.707898177720919,0.179795658963104,1.38514861092289,-5.04604287474214,1.81693511223794,"PXDNL","peroxidasin like",TRUE
+"225796_at",0.562414216355319,0.0550274651793485,-2.02549511105289,-4.11748451790902,-1.10670669273337,"PXK","PX domain containing serine/threonine kinase like",TRUE
+"1552275_s_at",0.630603891142543,0.101994437642737,-1.70596938934323,-4.61362585580781,-1.34240707146533,"PXK","PX domain containing serine/threonine kinase like",TRUE
+"1552274_at",0.726696341943087,0.206641258553382,-1.30095562214325,-5.14733301737864,-0.716446431331326,"PXK","PX domain containing serine/threonine kinase like",TRUE
+"238223_at",0.980251716625976,0.907402061006649,0.117653755183377,-5.93294360330047,0.0499983211244697,"PXK","PX domain containing serine/threonine kinase like",TRUE
+"219076_s_at",0.760439386481756,0.259420692497879,1.15743418547949,-5.30743744904989,0.322735016998863,"PXMP2","peroxisomal membrane protein 2",TRUE
+"238746_at",0.863559206655094,0.488688628985167,-0.704127157553136,-5.70104282595352,-0.697216166303289,"PXMP4","peroxisomal membrane protein 4",TRUE
+"224210_s_at",0.904639315370171,0.608610055096677,0.519431862146374,-5.80911683052913,0.436034773861422,"PXMP4","peroxisomal membrane protein 4",TRUE
+"219428_s_at",0.932091525948902,0.700636863028391,0.389483581809195,-5.86606612531729,0.22059988170027,"PXMP4","peroxisomal membrane protein 4",TRUE
+"201087_at",0.517654151778308,0.0367226094910667,2.22303120507824,-3.78262325568121,0.770304552705342,"PXN","paxillin",TRUE
+"211823_s_at",0.554475617948299,0.0508581158856101,2.06461630252012,-4.05275534782817,1.48180059085466,"PXN","paxillin",TRUE
+"227332_at",0.585036027492332,0.0651611770876959,-1.94040598974344,-4.25540275812497,-1.49801540480769,"PXN-AS1","PXN antisense RNA 1",TRUE
+"1552599_at",0.775757729721894,0.293106596810149,1.07691033333701,-5.39007394690029,0.655892136545998,"PXT1","peroxisomal, testis specific 1",TRUE
+"226925_at",0.358427723880268,0.0099918722772213,2.81724785330525,-2.67312470052636,1.58425227437835,"PXYLP1","2-phosphoxylose phosphatase 1",TRUE
+"239475_at",0.628171302042067,0.0995423166144027,1.71907816029821,-4.59448595973933,0.911088355301872,"PXYLP1","2-phosphoxylose phosphatase 1",TRUE
+"221666_s_at",0.778686132916778,0.299460372388676,1.06248282379012,-5.40431941423602,1.72632314338316,"PYCARD","PYD and CARD domain containing",TRUE
+"244497_at",0.881875934621979,0.538845282049562,0.62423957409242,-5.75164879524313,0.459140156802901,"PYCARD-AS1","PYCARD antisense RNA 1",TRUE
+"202148_s_at",0.632949074657601,0.103673549092352,-1.69714684522665,-4.62644561652439,-0.795630682817455,"PYCR1","pyrroline-5-carboxylate reductase 1",TRUE
+"218944_at",0.974670398319743,0.876127587254299,0.157692260509179,-5.92757900828368,0.135103048085924,"PYCRL","pyrroline-5-carboxylate reductase-like",TRUE
+"243722_at",0.901430889731657,0.59821474153115,0.534653006614215,-5.80140555116382,0.371799699231802,"PYDC1","pyrin domain containing 1",TRUE
+"243238_at",0.841967750949524,0.434617137662459,0.795755617717232,-5.63588044453082,0.369399177807953,"PYGB","phosphorylase, glycogen; brain",TRUE
+"201481_s_at",0.995375928428862,0.978401332935801,-0.0273805501980652,-5.93931833878185,-0.0358087829887808,"PYGB","phosphorylase, glycogen; brain",TRUE
+"202990_at",0.645740804644555,0.116827723730104,1.63192745186872,-4.71964715814429,1.91080339051295,"PYGL","phosphorylase, glycogen, liver",TRUE
+"205577_at",0.889389445320988,0.557200656998011,0.596022492765756,-5.76812339880335,0.398801055529851,"PYGM","phosphorylase, glycogen, muscle",TRUE
+"239741_at",0.794620886196317,0.326571980899681,1.00324943601601,-5.46099138574669,0.935591086766544,"PYGO1","pygopus family PHD finger 1",TRUE
+"215520_at",0.85334340854827,0.460984236890401,0.750272512103981,-5.66916863239605,0.577587615607917,"PYGO1","pygopus family PHD finger 1",TRUE
+"215517_at",0.8877101263145,0.552739605981488,0.60283469770737,-5.76421340973049,0.551780428764194,"PYGO1","pygopus family PHD finger 1",TRUE
+"225370_at",0.722937902375896,0.199508534177636,-1.32244705761127,-5.12198469965712,-0.41357692049386,"PYGO2","pygopus family PHD finger 2",TRUE
+"239666_at",0.98693003519805,0.939766149989916,-0.0764259384865502,-5.93683898237219,-0.0399921396949807,"PYGO2","pygopus family PHD finger 2",TRUE
+"216748_at",0.564767153272501,0.056079028351466,2.01604662447158,-4.13299510167904,0.623779619232535,"PYHIN1","pyrin and HIN domain family member 1",TRUE
+"240413_at",0.868313695469383,0.502715770545612,-0.681340675520517,-5.71607120458637,-0.66231010555009,"PYHIN1","pyrin and HIN domain family member 1",TRUE
+"1569428_at",0.819780516863333,0.37734802276355,-0.900865528324795,-5.55194960226171,-0.751756363677214,"PYM1","PYM homolog 1, exon junction complex associated factor",TRUE
+"224465_s_at",0.890480017681882,0.559152594076003,-0.593050749214739,-5.76981563489844,-0.266467268598525,"PYM1","PYM homolog 1, exon junction complex associated factor",TRUE
+"219802_at",0.946727564264032,0.758494826682178,0.311283737766559,-5.89259813734775,0.193833510164714,"PYROXD1","pyridine nucleotide-disulphide oxidoreductase domain 1",TRUE
+"231173_at",0.94895689004559,0.768670627349778,-0.297746470246032,-5.89659589894638,-0.350311873678351,"PYROXD1","pyridine nucleotide-disulphide oxidoreductase domain 1",TRUE
+"213878_at",0.986361618040699,0.935634672899271,0.0816798463875293,-5.93643451403523,0.0506987676614443,"PYROXD1","pyridine nucleotide-disulphide oxidoreductase domain 1",TRUE
+"228384_s_at",0.744152356003007,0.234948241402661,1.22092505555141,-5.23860288407209,1.41813892792858,"PYROXD2","pyridine nucleotide-disulphide oxidoreductase domain 2",TRUE
+"232942_at",0.76719388846109,0.269132244699329,1.13347183772219,-5.33257891167787,0.780600982642645,"PYROXD2","pyridine nucleotide-disulphide oxidoreductase domain 2",TRUE
+"224661_at",0.804537788156734,0.343452173430629,-0.968083208370668,-5.49324184177708,-0.385377953246634,"PYURF///PIGY","PIGY upstream reading frame///phosphatidylinositol glycan anchor biosynthesis class Y",TRUE
+"224660_at",0.943988850936011,0.749801698365552,-0.322895653827273,-5.88902869509073,-0.103143073773655,"PYURF///PIGY","PIGY upstream reading frame///phosphatidylinositol glycan anchor biosynthesis class Y",TRUE
+"211253_x_at",0.901797819916539,0.599787961327999,0.532341312834838,-5.80259065255578,0.404240838323644,"PYY","peptide YY",TRUE
+"207080_s_at",0.976746068767032,0.889048831426796,-0.141121921819182,-5.92998807799318,-0.14456007656676,"PYY","peptide YY",TRUE
+"220209_at",0.908532549756419,0.619596766031414,-0.503478643790096,-5.8169660123402,-0.30579395239374,"PYY2","peptide YY, 2 (pseudogene)",TRUE
+"207330_at",0.874474734833648,0.520751057360633,0.652563947676867,-5.73437422289281,0.354420384275183,"PZP","PZP, alpha-2-macroglobulin like",TRUE
+"209123_at",0.886783047600321,0.550105088171333,0.606871244365515,-5.76187631853995,0.302268902945233,"QDPR","quinoid dihydropteridine reductase",TRUE
+"238616_at",0.930899509890345,0.694296154609635,-0.398196762128993,-5.86274813315038,-0.293493248995603,"QDPR","quinoid dihydropteridine reductase",TRUE
+"214543_x_at",0.322131160460075,0.00727633979280942,2.95535601728623,-2.39798093971992,1.32594049072751,"QKI","QKI, KH domain containing RNA binding",TRUE
+"212263_at",0.323181420165577,0.00731776128331018,2.95290106336618,-2.40291719364454,1.35678193973329,"QKI","QKI, KH domain containing RNA binding",TRUE
+"1555154_a_at",0.384135218769668,0.0124638318091581,2.71972371540886,-2.86403824524695,1.28278527396073,"QKI","QKI, KH domain containing RNA binding",TRUE
+"214541_s_at",0.457032025390949,0.0226002795993688,2.45088576214265,-3.37349347074189,1.33617188753337,"QKI","QKI, KH domain containing RNA binding",TRUE
+"228540_at",0.535697382361465,0.0429588147899789,2.14735657812209,-3.91322960328891,1.61002510571675,"QKI","QKI, KH domain containing RNA binding",TRUE
+"212262_at",0.539609110035715,0.0444564006659016,2.13067286239407,-3.94164429348459,0.958641352625005,"QKI","QKI, KH domain containing RNA binding",TRUE
+"241938_at",0.54775309185967,0.0481371215440783,2.09172496365715,-4.00742908831954,0.754947461265194,"QKI","QKI, KH domain containing RNA binding",TRUE
+"212636_at",0.56559911410714,0.0565744555671103,2.0116496412455,-4.14019671576608,1.63652797911632,"QKI","QKI, KH domain containing RNA binding",TRUE
+"212265_at",0.634232520114868,0.105413756707776,1.68813040814512,-4.63949540856319,0.689661923667709,"QKI","QKI, KH domain containing RNA binding",TRUE
+"236154_at",0.990810941805126,0.95486148173043,0.0572471224780513,-5.9380873874256,0.0518133249035415,"QKI","QKI, KH domain containing RNA binding",TRUE
+"205174_s_at",0.807084045192774,0.3484288530313,0.957942169181464,-5.502347017738,1.51435684479074,"QPCT","glutaminyl-peptide cyclotransferase",TRUE
+"220438_at",0.973095316327004,0.870793498709307,-0.16454568374287,-5.92650470687759,-0.0962646952921657,"QPCTL","glutaminyl-peptide cyclotransferase like",TRUE
+"242414_at",0.783193756405113,0.305671176368152,-1.04858941346162,-5.41787467766969,-0.975095499569592,"QPRT","quinolinate phosphoribosyltransferase",TRUE
+"204044_at",0.920077265976268,0.659628507942163,-0.446417102955594,-5.84308092744274,-0.643089279193195,"QPRT","quinolinate phosphoribosyltransferase",TRUE
+"1555533_at",0.966561892743893,0.843945097351636,-0.199171408484913,-5.92038050107584,-0.178727417518866,"QRFPR","pyroglutamylated RFamide peptide receptor",TRUE
+"229806_at",0.925588405327733,0.678392394452643,0.420191709983208,-5.85405106952022,0.165845451348976,"QRICH1","glutamine rich 1",TRUE
+"209174_s_at",0.986342822130003,0.933258947724092,-0.0847020608625891,-5.93618968002847,-0.0243496104797263,"QRICH1","glutamine rich 1",TRUE
+"232532_at",0.959649219607517,0.81798592173371,-0.232888491650525,-5.91330108632198,-0.155767308177008,"QRICH2","glutamine rich 2",TRUE
+"233089_at",0.846015118644589,0.444023519203037,0.779341823546452,-5.64810646369622,0.528480237321294,"QRSL1","glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1",TRUE
+"241933_at",0.848937021892,0.44951260412373,-0.769861606321668,-5.65505845106809,-0.448502151283211,"QRSL1","glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1",TRUE
+"218948_at",0.8920930097751,0.563942609366414,-0.585780849827741,-5.77392094546869,-0.2834870475863,"QRSL1","glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1",TRUE
+"218949_s_at",0.948071428905202,0.764023436089132,0.303921611420546,-5.89479413402977,0.108773843663041,"QRSL1","glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1",TRUE
+"219705_at",0.904432955312383,0.608171259116814,0.520071830540906,-5.80879697990235,0.186935410358874,"QSER1","glutamine and serine rich 1",TRUE
+"244563_at",0.929786324276714,0.690176094572847,0.403875223637938,-5.86054685981487,0.147358917550601,"QSER1","glutamine and serine rich 1",TRUE
+"229982_at",0.962050375516713,0.827671249447739,0.220278532102856,-5.91607749189802,0.0904631269836891,"QSER1","glutamine and serine rich 1",TRUE
+"226265_at",0.991689960875868,0.961202846419187,-0.0491973190741686,-5.93850467349676,-0.0161920116449483,"QSER1","glutamine and serine rich 1",TRUE
+"230523_at",0.634202341398092,0.105377227424474,1.68831837339456,-4.63922389517369,1.04008493558021,"QSOX1","quiescin sulfhydryl oxidase 1",TRUE
+"201482_at",0.822010986888098,0.385626999955209,0.88506322742506,-5.5651854910461,0.64654684018914,"QSOX1","quiescin sulfhydryl oxidase 1",TRUE
+"235239_at",0.673366993714442,0.139505966550233,1.53269669912046,-4.85601030239622,1.47494389854658,"QSOX2","quiescin sulfhydryl oxidase 2",TRUE
+"227146_at",0.885550062409064,0.547170329371109,0.611379818042753,-5.75924813969749,0.234282158072688,"QSOX2","quiescin sulfhydryl oxidase 2",TRUE
+"221270_s_at",0.821424121108148,0.383096321661245,0.889869797558464,-5.56118249424851,0.357824173239781,"QTRT1","queuine tRNA-ribosyltransferase catalytic subunit 1",TRUE
+"1560695_at",0.384135218769668,0.0124646219717618,2.71969558504492,-2.86409288005558,2.2317388131034,"QTRT2","queuine tRNA-ribosyltransferase accessory subunit 2",TRUE
+"1560696_x_at",0.904381089098038,0.608031905883032,-0.520275118305929,-5.80869529815283,-0.522966692230349,"QTRT2","queuine tRNA-ribosyltransferase accessory subunit 2",TRUE
+"219178_at",0.9202957869034,0.660810993666928,-0.444755169799436,-5.84379545957716,-0.148637082518295,"QTRT2","queuine tRNA-ribosyltransferase accessory subunit 2",TRUE
+"35156_at",0.896115372949367,0.577663508826329,-0.56512973610675,-5.78531516548089,-0.189657885496779,"R3HCC1","R3H domain and coiled-coil containing 1",TRUE
+"212866_at",0.913627134030439,0.63763180500966,-0.477572813653791,-5.8292025897259,-0.158252134444684,"R3HCC1","R3H domain and coiled-coil containing 1",TRUE
+"210455_at",0.54344488073991,0.0463269576876046,2.11053140347988,-3.97576084494726,0.7451990826152,"R3HCC1L","R3H domain and coiled-coil containing 1 like",TRUE
+"228374_at",0.908667507590078,0.620044236284293,0.502831721421326,-5.8172792674942,0.128037053445611,"R3HCC1L","R3H domain and coiled-coil containing 1 like",TRUE
+"202754_at",0.663985642001593,0.132009720490422,-1.56391147783835,-4.81383763405185,-0.414342760692866,"R3HDM1","R3H domain containing 1",TRUE
+"210714_at",0.868220463162593,0.502216927922841,0.682144775788187,-5.71554891457251,0.355812224523433,"R3HDM1","R3H domain containing 1",TRUE
+"203831_at",0.741143136625128,0.231385757492323,-1.23057729317291,-5.22785916251627,-0.504939650458866,"R3HDM2","R3H domain containing 2",TRUE
+"221764_at",0.79943091106207,0.33400594401907,-0.987611709578934,-5.47546179089842,-0.271829039566786,"R3HDM4","R3H domain containing 4",TRUE
+"55705_at",0.916790160854655,0.648339988248399,-0.462347940343656,-5.83609906677019,-0.0954968740114488,"R3HDM4","R3H domain containing 4",TRUE
+"234774_at",0.792257368722412,0.323177249101343,1.01047261363774,-5.4542377868757,0.629603171747038,"R3HDML","R3H domain containing like",TRUE
+"222981_s_at",0.804537788156734,0.343423999047617,0.968140903857518,-5.49318978904483,0.280333056238316,"RAB10","RAB10, member RAS oncogene family",TRUE
+"222980_at",0.90344422113846,0.603751541758854,0.526530170169196,-5.80554769145925,0.130229820595439,"RAB10","RAB10, member RAS oncogene family",TRUE
+"200864_s_at",0.40221114169538,0.0145623919334053,-2.65037325474472,-2.99793366762856,-1.07792619567228,"RAB11A","RAB11A, member RAS oncogene family",TRUE
+"234998_at",0.627938764248877,0.0992840639239211,-1.72047471216176,-4.59244042347467,-0.7375528186637,"RAB11A","RAB11A, member RAS oncogene family",TRUE
+"200863_s_at",0.68680805784522,0.155350270336543,-1.47100502025892,-4.93736015246705,-0.481769045721832,"RAB11A","RAB11A, member RAS oncogene family",TRUE
+"34478_at",0.62986301194198,0.100856810725479,1.71201726388034,-4.60480908100844,0.693549298875088,"RAB11B","RAB11B, member RAS oncogene family",TRUE
+"217793_at",0.719333457476224,0.195291113787136,1.33543797121451,-5.10649266930669,0.396042503701644,"RAB11B","RAB11B, member RAS oncogene family",TRUE
+"1556122_at",0.709806520482984,0.182592200498841,1.37593317888513,-5.05738807184729,0.616308754624102,"RAB11B-AS1","RAB11B antisense RNA 1",TRUE
+"1556123_a_at",0.801837936177267,0.339338200631904,0.976542291602637,-5.48557986350484,0.764096313130308,"RAB11B-AS1","RAB11B antisense RNA 1",TRUE
+"225177_at",0.755868740464627,0.250246798119336,-1.18068766277831,-5.28259887355531,-0.973712303866401,"RAB11FIP1","RAB11 family interacting protein 1",TRUE
+"219681_s_at",0.779128226525695,0.300265402123876,-1.06067049801337,-5.40609670689052,-0.790253222901786,"RAB11FIP1","RAB11 family interacting protein 1",TRUE
+"231830_x_at",0.839519981963042,0.427432097095539,-0.808441435658345,-5.62626711425345,-0.46093417497309,"RAB11FIP1","RAB11 family interacting protein 1",TRUE
+"203884_s_at",0.939976205834042,0.729927109529792,-0.349617333333782,-5.88032337324002,-0.146217998288108,"RAB11FIP2","RAB11 family interacting protein 2",TRUE
+"203883_s_at",0.987967825391489,0.942512853987516,0.0729342446718644,-5.93709292724768,0.0336760089395156,"RAB11FIP2","RAB11 family interacting protein 2",TRUE
+"214999_s_at",0.398650588126476,0.01399411284953,-2.66817153281916,-2.9637247978019,-0.82365990102113,"RAB11FIP3","RAB11 family interacting protein 3",TRUE
+"228613_at",0.501591596209182,0.032268557767874,-2.28461087273902,-3.67432960057626,-1.11585538947012,"RAB11FIP3","RAB11 family interacting protein 3",TRUE
+"203933_at",0.752913428584105,0.246194697887652,-1.19116135731058,-5.27127029783465,-0.527644122145606,"RAB11FIP3","RAB11 family interacting protein 3",TRUE
+"224482_s_at",0.626983082753167,0.0974369042565057,-1.7305549378645,-4.57763915814606,-1.68950824026293,"RAB11FIP4","RAB11 family interacting protein 4",TRUE
+"216719_s_at",0.839912678262994,0.428751035213903,0.806102874050637,-5.62805001671954,0.394788604552977,"RAB11FIP4","RAB11 family interacting protein 4",TRUE
+"225739_at",0.860696412805564,0.48025731376497,-0.718004740502405,-5.69165929965351,-0.506472872256976,"RAB11FIP4","RAB11 family interacting protein 4",TRUE
+"225746_at",0.993919358691598,0.971513055150817,-0.0361162832473067,-5.93904818243208,-0.0426423232278079,"RAB11FIP4","RAB11 family interacting protein 4",TRUE
+"210879_s_at",0.7768734672127,0.294501507084395,1.07372387914774,-5.39323498139053,0.436554943101342,"RAB11FIP5","RAB11 family interacting protein 5",TRUE
+"236019_at",0.61760967235709,0.0879066352717088,1.78532163035257,-4.49610819339305,0.812380768964357,"RAB12","RAB12, member RAS oncogene family",TRUE
+"235059_at",0.862639573412331,0.486260287621193,0.708109795551551,-5.69836775468113,0.865940776675524,"RAB12","RAB12, member RAS oncogene family",TRUE
+"239891_x_at",0.934867348047609,0.7108449465625,-0.375519872341447,-5.87123261208125,-0.148727751270982,"RAB12","RAB12, member RAS oncogene family",TRUE
+"202252_at",0.580630437263151,0.0630976584478278,-1.95673298016158,-4.22925004978726,-0.595355679623729,"RAB13","RAB13, member RAS oncogene family",TRUE
+"200927_s_at",0.470885186348082,0.025435452471576,-2.39621453011427,-3.47371080448638,-0.808123136736832,"RAB14","RAB14, member RAS oncogene family",TRUE
+"211503_s_at",0.573251467365028,0.0601927146619593,-1.98053572626899,-4.19085555060135,-0.747114609241349,"RAB14","RAB14, member RAS oncogene family",TRUE
+"200928_s_at",0.885312914741353,0.546502276999661,-0.612407908888486,-5.75864620833412,-0.249481044572282,"RAB14","RAB14, member RAS oncogene family",TRUE
+"221810_at",0.920800738105699,0.663293480222314,-0.441270269950423,-5.84528526812516,-0.324795522184854,"RAB15","RAB15, member RAS oncogene family",TRUE
+"59697_at",0.959079034903479,0.81447192765878,-0.237473041947157,-5.912253578535,-0.15516854379878,"RAB15","RAB15, member RAS oncogene family",TRUE
+"218931_at",0.83949628091616,0.426028363467272,-0.8109352858403,-5.6243604796411,-0.404535541220181,"RAB17","RAB17, member RAS oncogene family",TRUE
+"224787_s_at",0.595935839284243,0.0723297710011932,-1.88701458489239,-4.33986618967696,-0.685701948278739,"RAB18","RAB18, member RAS oncogene family",TRUE
+"223336_s_at",0.621368540129578,0.0918446892717676,-1.76210173837746,-4.53090380968067,-0.634599338072285,"RAB18","RAB18, member RAS oncogene family",TRUE
+"243496_at",0.622434989367596,0.0925899719179887,-1.75780393524131,-4.53730749952655,-0.947435284118326,"RAB18","RAB18, member RAS oncogene family",TRUE
+"224377_s_at",0.626410545792261,0.0971208449324371,-1.73229603851542,-4.5750761022105,-0.573682882266834,"RAB18","RAB18, member RAS oncogene family",TRUE
+"239637_at",0.899808883319249,0.593245972023575,0.541973609909669,-5.79761966036038,0.443219585514456,"RAB18","RAB18, member RAS oncogene family",TRUE
+"229398_at",0.913342687538603,0.636783880420195,0.478783251184366,-5.82864491111402,0.185536248539385,"RAB18","RAB18, member RAS oncogene family",TRUE
+"239570_at",0.80818658267298,0.350020002254744,-0.954720658670224,-5.50522110957663,-0.467554738835831,"RAB1A","RAB1A, member RAS oncogene family",TRUE
+"213440_at",0.919315730071839,0.656140059160372,0.451327441186535,-5.84095450469127,0.127396676685045,"RAB1A","RAB1A, member RAS oncogene family",TRUE
+"207791_s_at",0.956715220855023,0.803378312206599,0.251981096610095,-5.90880489567988,0.0685019268886418,"RAB1A","RAB1A, member RAS oncogene family",TRUE
+"208724_s_at",0.978197434639598,0.894284528595453,0.134419378117825,-5.93088677691713,0.029606013083681,"RAB1A","RAB1A, member RAS oncogene family",TRUE
+"220964_s_at",0.602624067324723,0.0772416911533911,-1.85304656087692,-4.39274150522833,-0.764733368279805,"RAB1B","RAB1B, member RAS oncogene family",TRUE
+"219622_at",0.980439435497171,0.908703645347329,0.115992152383157,-5.93313256989569,0.0982162513194975,"RAB20","RAB20, member RAS oncogene family",TRUE
+"237373_at",0.982844899319041,0.91654882834163,-0.105983898858911,-5.93421398234323,-0.0759771600137604,"RAB20","RAB20, member RAS oncogene family",TRUE
+"239329_at",0.659310154140908,0.12720736746287,-1.58468833522405,-4.78539672613546,-0.567986382758326,"RAB21","RAB21, member RAS oncogene family",TRUE
+"241263_at",0.710842845257879,0.184459021764244,1.3698435212641,-5.06485056128317,0.498578170938786,"RAB21","RAB21, member RAS oncogene family",TRUE
+"226268_at",0.745083412128071,0.236806913984689,-1.21593306654628,-5.24413066672112,-0.517394787919002,"RAB21","RAB21, member RAS oncogene family",TRUE
+"203885_at",0.871451481476429,0.512487221752864,-0.665679396111782,-5.72612616075288,-0.242530426850429,"RAB21","RAB21, member RAS oncogene family",TRUE
+"218360_at",0.699161781955613,0.170617333562722,-1.41621816229447,-5.00733189481512,-0.643112549169913,"RAB22A","RAB22A, member RAS oncogene family",TRUE
+"213405_at",0.741816732763138,0.232356014577812,-1.22793736613107,-5.23080487364734,-0.534933922025262,"RAB22A","RAB22A, member RAS oncogene family",TRUE
+"215507_x_at",0.910159094731364,0.625954470849055,-0.494307340201119,-5.82137024864164,-0.199723826105997,"RAB22A","RAB22A, member RAS oncogene family",TRUE
+"229504_at",0.728385463227073,0.208766490816189,1.2946637123719,-5.15468749743159,0.847050507490642,"RAB23","RAB23, member RAS oncogene family",TRUE
+"220955_x_at",0.834504305810205,0.413062460505561,0.834217582754503,-5.60629496145328,0.374741243209728,"RAB23","RAB23, member RAS oncogene family",TRUE
+"223463_at",0.88587213211399,0.547810587781632,0.610395123286103,-5.75982374870828,0.298901628085526,"RAB23","RAB23, member RAS oncogene family",TRUE
+"225251_at",0.123760100530367,0.00071981183298869,-3.92302117455149,-0.366596087498125,-1.47964578758598,"RAB24","RAB24, member RAS oncogene family",TRUE
+"218186_at",0.913572663544659,0.637416733805233,0.477879765604766,-5.82906130003138,0.700230307987303,"RAB25","RAB25, member RAS oncogene family",TRUE
+"50965_at",0.732963666545614,0.21730911212311,-1.26986139160747,-5.18338272463011,-0.761197058191138,"RAB26","RAB26, member RAS oncogene family",TRUE
+"219562_at",0.792716268502624,0.324425475792902,-1.00781057690188,-5.45673187349643,-0.789084615006499,"RAB26","RAB26, member RAS oncogene family",TRUE
+"210951_x_at",0.721317419960934,0.197601831451152,-1.32829340170952,-5.1150285430307,-0.768655126835574,"RAB27A","RAB27A, member RAS oncogene family",TRUE
+"222294_s_at",0.819807973515613,0.377748718414065,-0.900095494573232,-5.55259959882439,-0.573473285681459,"RAB27A","RAB27A, member RAS oncogene family",TRUE
+"209514_s_at",0.841618504666446,0.433434545379353,-0.797834610523222,-5.6343147720982,-0.354622623394555,"RAB27A","RAB27A, member RAS oncogene family",TRUE
+"235766_x_at",0.896907177224677,0.58201203415193,-0.558636732621345,-5.78881576098203,-0.333058014061876,"RAB27A","RAB27A, member RAS oncogene family",TRUE
+"209515_s_at",0.976422537443518,0.887801498397196,-0.142719676042254,-5.92976740467509,-0.0807464209756361,"RAB27A","RAB27A, member RAS oncogene family",TRUE
+"207018_s_at",0.914910510855952,0.641741820498578,-0.471715847876054,-5.831881527409,-0.282179710603107,"RAB27B","RAB27B, member RAS oncogene family",TRUE
+"207017_at",0.962555471240652,0.82974080367465,-0.217588845071691,-5.91664979649583,-0.193149144942681,"RAB27B","RAB27B, member RAS oncogene family",TRUE
+"228708_at",0.990810941805126,0.955734772124999,-0.0561383394007394,-5.93814861145906,-0.0496808116208083,"RAB27B","RAB27B, member RAS oncogene family",TRUE
+"209084_s_at",0.804351886842858,0.343101869317771,-0.968800790783951,-5.49259423915984,-0.30747345779981,"RAB28","RAB28, member RAS oncogene family",TRUE
+"227003_at",0.860819742788118,0.480755545113033,-0.717180760733353,-5.69222131328978,-0.214393781056041,"RAB28","RAB28, member RAS oncogene family",TRUE
+"234628_at",0.871744769522775,0.514001634093661,0.663267156675049,-5.72765498085253,0.222580625724933,"RAB28","RAB28, member RAS oncogene family",TRUE
+"207495_at",0.954054753819891,0.789038850991837,-0.270816757103554,-5.90402443424133,-0.0797083138890944,"RAB28","RAB28, member RAS oncogene family",TRUE
+"234674_at",0.98529096111871,0.926629301043149,-0.093140155180218,-5.93545904812051,-0.0304272020143035,"RAB28","RAB28, member RAS oncogene family",TRUE
+"218699_at",0.571677937624457,0.0593393524962242,-1.98772130333069,-4.17920332037652,-1.0467820211176,"RAB29","RAB29, member RAS oncogene family",TRUE
+"218700_s_at",0.620912785033482,0.0906745872578288,-1.76891013458677,-4.5207358392258,-1.08354379870093,"RAB29","RAB29, member RAS oncogene family",TRUE
+"243777_at",0.668403802227594,0.134527405132555,-1.55326810560041,-4.82829276716553,-0.715468927812563,"RAB29","RAB29, member RAS oncogene family",TRUE
+"208732_at",0.784708646973769,0.308728376572461,-1.04182399858694,-5.42441738154654,-0.455885433831646,"RAB2A","RAB2A, member RAS oncogene family",TRUE
+"208734_x_at",0.819479221404744,0.376437141235615,-0.902618014755691,-5.55046838821457,-0.340507815671071,"RAB2A","RAB2A, member RAS oncogene family",TRUE
+"208731_at",0.835973067952943,0.417198576458411,-0.826741232269159,-5.61214829757033,-0.282093085986315,"RAB2A","RAB2A, member RAS oncogene family",TRUE
+"221960_s_at",0.942049201741017,0.739465626250554,0.33676147951939,-5.88459693432876,0.124349756324595,"RAB2A","RAB2A, member RAS oncogene family",TRUE
+"208733_at",0.962808206628386,0.830944169564022,-0.216025651663689,-5.91697919284855,-0.107050340850254,"RAB2A","RAB2A, member RAS oncogene family",TRUE
+"208730_x_at",0.976710390868127,0.888944901150064,-0.141255035465033,-5.9299697877285,-0.0344871783300373,"RAB2A","RAB2A, member RAS oncogene family",TRUE
+"225074_at",0.92949192138025,0.689634554782098,-0.404622601014607,-5.86025485156869,-0.115849203178831,"RAB2B","RAB2B, member RAS oncogene family",TRUE
+"228390_at",0.528768444275307,0.0411701196630868,-2.16798592598974,-3.87790306863431,-2.27033296838913,"RAB30","RAB30, member RAS oncogene family",TRUE
+"228003_at",0.775581183114088,0.292877553678859,-1.077434585269,-5.38955307534901,-0.743796021145128,"RAB30","RAB30, member RAS oncogene family",TRUE
+"229072_at",0.835289077598304,0.414502197459758,-0.83160980238329,-5.60834222545633,-0.821964454774167,"RAB30","RAB30, member RAS oncogene family",TRUE
+"206530_at",0.950214160603623,0.774101094550558,-0.290545445864466,-5.89865067425432,-0.166255370816975,"RAB30","RAB30, member RAS oncogene family",TRUE
+"227842_at",0.974884920935236,0.877152019434969,-0.156376929247065,-5.92777997761977,-0.106091614555769,"RAB30","RAB30, member RAS oncogene family",TRUE
+"228612_at",0.732320150624823,0.216685543117442,1.27164616157381,-5.18133362931658,0.432681145604841,"RAB30-AS1","RAB30 antisense RNA 1 (head to head)",TRUE
+"228643_at",0.995375928428862,0.978455731393147,0.0273115715298973,-5.93932017620498,0.0115977517179688,"RAB30-AS1","RAB30 antisense RNA 1 (head to head)",TRUE
+"217762_s_at",0.635368778245437,0.106341791462488,1.68337352737733,-4.64635906090498,2.13744644006741,"RAB31","RAB31, member RAS oncogene family",TRUE
+"217763_s_at",0.676686243054906,0.143617140638484,1.51615983098858,-4.87807887528644,2.22600815245073,"RAB31","RAB31, member RAS oncogene family",TRUE
+"217764_s_at",0.683838837468118,0.152725558776271,1.48085865607651,-4.92454691124612,1.86974338737144,"RAB31","RAB31, member RAS oncogene family",TRUE
+"204214_s_at",0.737488397392592,0.223583152038167,1.25211909902683,-5.2036186544302,0.810894758665929,"RAB32","RAB32, member RAS oncogene family",TRUE
+"228161_at",0.763650705722297,0.263590596352695,1.14706570365539,-5.31837293997194,0.336946490307142,"RAB32","RAB32, member RAS oncogene family",TRUE
+"206039_at",0.816800680706682,0.368333859002325,0.918333139101732,-5.53706712476077,0.437934020577488,"RAB33A","RAB33A, member RAS oncogene family",TRUE
+"221014_s_at",0.793016712530949,0.324875703436247,-1.0068521463182,-5.4576283763682,-0.336264373585188,"RAB33B","RAB33B, member RAS oncogene family",TRUE
+"221819_at",0.81931756131977,0.376264191077789,-0.902951077182354,-5.55018658063714,-0.26026031475935,"RAB35","RAB35, member RAS oncogene family",TRUE
+"205461_at",0.959451355429682,0.81689611120505,0.234309767997032,-5.91297851626685,0.0886131989046746,"RAB35","RAB35, member RAS oncogene family",TRUE
+"225620_at",0.967701855457407,0.848042116540387,0.193872525779325,-5.92139301904621,0.0629794492694273,"RAB35","RAB35, member RAS oncogene family",TRUE
+"211471_s_at",0.971511156698413,0.864342746619294,0.172844658979186,-5.92514280232872,0.0942776465982575,"RAB36","RAB36, member RAS oncogene family",TRUE
+"228113_at",0.792611633508961,0.324207689950062,-1.00827452477268,-5.45629762536916,-0.719993701611989,"RAB37","RAB37, member RAS oncogene family",TRUE
+"219412_at",0.51470556386048,0.0349304867562402,2.24694235056346,-3.74078312583983,3.24660881438727,"RAB38","RAB38, member RAS oncogene family",TRUE
+"1554800_at",0.812302873476553,0.357242913661363,0.940220160867996,-5.51804796944098,0.387607537811381,"RAB39A","RAB39A, member RAS oncogene family",TRUE
+"238695_s_at",0.642592458809121,0.112898509138615,-1.65073085535129,-4.69306191698108,-2.32718424229414,"RAB39B","RAB39B, member RAS oncogene family",TRUE
+"230075_at",0.7768734672127,0.294924818978707,-1.07275902889133,-5.3941904829561,-1.55993517178129,"RAB39B","RAB39B, member RAS oncogene family",TRUE
+"204974_at",0.479626310794066,0.0269222340709097,-2.36976142703026,-3.52175309388235,-1.80601088340324,"RAB3A","RAB3A, member RAS oncogene family",TRUE
+"227123_at",0.532079878820242,0.0418267822436104,2.16032005353858,-3.89105503718024,2.89703386328061,"RAB3B","RAB3B, member RAS oncogene family",TRUE
+"239202_at",0.55937703282623,0.05332902402946,2.04110115654909,-4.09176068470399,1.99514610759385,"RAB3B","RAB3B, member RAS oncogene family",TRUE
+"205924_at",0.565130001938683,0.0564458150999021,2.01278804120079,-4.13833318834197,2.78635284294832,"RAB3B","RAB3B, member RAS oncogene family",TRUE
+"242629_at",0.594972224548427,0.0714831684542077,1.89307177049851,-4.33036649612607,1.43268258621805,"RAB3B","RAB3B, member RAS oncogene family",TRUE
+"205925_s_at",0.634442479135411,0.105514137407925,1.68761417297305,-4.64024098625122,1.50152497794911,"RAB3B","RAB3B, member RAS oncogene family",TRUE
+"241977_s_at",0.764430688544079,0.264498638995937,1.14482392598434,-5.32072593169817,0.490487840091468,"RAB3C","RAB3C, member RAS oncogene family",TRUE
+"229300_at",0.796378050779806,0.328977198210824,0.998163217493486,-5.4657205813831,0.423109357573101,"RAB3C","RAB3C, member RAS oncogene family",TRUE
+"242328_at",0.86481525165637,0.492268385753851,0.698276848200096,-5.70494629457127,0.531905813202446,"RAB3C","RAB3C, member RAS oncogene family",TRUE
+"244170_at",0.933859583363678,0.707044602254469,-0.380709360288031,-5.86933424855937,-0.303668293172848,"RAB3C","RAB3C, member RAS oncogene family",TRUE
+"208466_at",0.955645941042265,0.797011980243112,-0.260331710926205,-5.9067277501521,-0.167775091204115,"RAB3D","RAB3D, member RAS oncogene family",TRUE
+"225001_at",0.997608949249317,0.988157436936356,-0.0150114022728687,-5.93957372546864,-0.0108380015799465,"RAB3D","RAB3D, member RAS oncogene family",TRUE
+"239527_at",0.621503477846441,0.0919039682827497,1.76175880198074,-4.53141520432425,0.888259889864271,"RAB3GAP1","RAB3 GTPase activating protein catalytic subunit 1",TRUE
+"213530_at",0.73826901296725,0.225084139928926,-1.24793107108047,-5.20835967300482,-0.330445753540584,"RAB3GAP1","RAB3 GTPase activating protein catalytic subunit 1",TRUE
+"213531_s_at",0.89855168781085,0.587891924579236,-0.549895542410924,-5.79346642117561,-0.156135070682286,"RAB3GAP1","RAB3 GTPase activating protein catalytic subunit 1",TRUE
+"212932_at",0.942502815705589,0.741957408521558,0.333412697451696,-5.88568414816806,0.120876445451188,"RAB3GAP1","RAB3 GTPase activating protein catalytic subunit 1",TRUE
+"216057_at",0.805584262266138,0.344879941963667,-0.965163643792037,-5.49587216676417,-0.916612423856177,"RAB3GAP2","RAB3 GTPase activating non-catalytic protein subunit 2",TRUE
+"202372_at",0.380084968057051,0.011800505526858,-2.74395521600362,-2.816880968141,-1.0818685020156,"RAB3GAP2///AURKAPS1","RAB3 GTPase activating non-catalytic protein subunit 2///aurora kinase A pseudogene 1",TRUE
+"202373_s_at",0.597879550155311,0.0753311900245084,-1.86602817448321,-4.37261419077283,-0.620800343452714,"RAB3GAP2///AURKAPS1","RAB3 GTPase activating non-catalytic protein subunit 2///aurora kinase A pseudogene 1",TRUE
+"202374_s_at",0.869574215769297,0.506979290447158,-0.674486457054656,-5.7204993301442,-0.269286402057793,"RAB3GAP2///AURKAPS1","RAB3 GTPase activating non-catalytic protein subunit 2///aurora kinase A pseudogene 1",TRUE
+"243851_at",0.996043632008689,0.980303683255959,-0.024968398612458,-5.93937983996155,-0.0138985217432603,"RAB3GAP2///AURKAPS1","RAB3 GTPase activating non-catalytic protein subunit 2///aurora kinase A pseudogene 1",TRUE
+"219579_at",0.796963640275795,0.329902588014095,0.996213197744521,-5.46752793458747,0.263947499035609,"RAB3IL1","RAB3A interacting protein like 1",TRUE
+"1565799_at",0.554642754132296,0.0512265744593734,-2.06104583011845,-4.0586966161852,-2.66522897160168,"RAB3IP","RAB3A interacting protein",TRUE
+"231399_at",0.881178591455433,0.537796953237793,-0.625866432986605,-5.75067656119981,-0.374231918893584,"RAB3IP","RAB3A interacting protein",TRUE
+"1565800_x_at",0.929088231432081,0.687367009092036,0.407754587633963,-5.85902537231475,0.420925590661554,"RAB3IP","RAB3A interacting protein",TRUE
+"223471_at",0.944694244923467,0.75126302275761,0.320940552568902,-5.8896387450057,0.226505962337086,"RAB3IP","RAB3A interacting protein",TRUE
+"238853_at",0.968271298107834,0.851017922944443,-0.190027330996508,-5.92211073205537,-0.126677879261342,"RAB3IP","RAB3A interacting protein",TRUE
+"238526_at",0.979588787486838,0.902823209851786,0.123501847023585,-5.93225717944032,0.130853028562292,"RAB3IP","RAB3A interacting protein",TRUE
+"228432_at",0.985760151191312,0.931275154814537,0.0872263075294817,-5.93597837497124,0.0437638052658409,"RAB3IP","RAB3A interacting protein",TRUE
+"217589_at",0.909052380289506,0.622835347383794,-0.49880141120375,-5.81922198572519,-0.381364008923048,"RAB40A","RAB40A, member RAS oncogene family",TRUE
+"215782_at",0.879948283821082,0.534805700475786,0.630517825189153,-5.74788338427516,0.433981533498526,"RAB40AL","RAB40A, member RAS oncogene family-like",TRUE
+"236211_at",0.73354700473818,0.217816838078177,-1.26841109114256,-5.18504600417615,-1.27987956356682,"RAB40B","RAB40B, member RAS oncogene family",TRUE
+"204547_at",0.859502367311367,0.477419285012782,-0.722707835469973,-5.68843970011314,-0.373914519751761,"RAB40B","RAB40B, member RAS oncogene family",TRUE
+"217597_x_at",0.92887602386045,0.68686170873711,0.408453084760549,-5.85874990091622,0.195996260454754,"RAB40B","RAB40B, member RAS oncogene family",TRUE
+"227698_s_at",0.766550448794594,0.267789532084849,-1.13674653383245,-5.32917041275902,-0.530458110471123,"RAB40C","RAB40C, member RAS oncogene family",TRUE
+"227269_s_at",0.900831880406409,0.596632778776824,0.536980523843152,-5.80020729134703,0.43417766955374,"RAB40C","RAB40C, member RAS oncogene family",TRUE
+"213466_at",0.994145854504594,0.973051638407357,0.0341648224784339,-5.93911497956135,0.0305878844210277,"RAB40C","RAB40C, member RAS oncogene family",TRUE
+"1552846_s_at",0.0694373323553232,0.000195580231965611,4.45508647661404,0.782213147659665,2.72302443571221,"RAB42","RAB42, member RAS oncogene family",TRUE
+"229894_s_at",0.807944276806637,0.349579691534521,0.955611134850795,-5.50442755148258,0.297578124814661,"RAB43","RAB43, member RAS oncogene family",TRUE
+"237257_at",0.580319028296073,0.0628559540113277,-1.95867611365274,-4.22612755516254,-1.20638022283571,"RAB4B","RAB4B, member RAS oncogene family",TRUE
+"220956_s_at",0.478691006415319,0.0268169284296322,-2.37159011769096,-3.51844155004832,-1.09202835735417,"RAB4B-EGLN2///EGLN2","RAB4B-EGLN2 readthrough (NMD candidate)///egl-9 family hypoxia inducible factor 2",TRUE
+"223083_s_at",0.695005304830231,0.164565885863649,-1.43744227868985,-4.98048238840374,-0.876783343906035,"RAB4B-EGLN2///EGLN2///RAB4B","RAB4B-EGLN2 readthrough (NMD candidate)///egl-9 family hypoxia inducible factor 2///RAB4B, member RAS oncogene family",TRUE
+"209089_at",0.610076166481657,0.0826710171279939,-1.81762236547985,-4.44715418072536,-0.494636194267654,"RAB5A","RAB5A, member RAS oncogene family",TRUE
+"206113_s_at",0.75208632565379,0.245234476703352,-1.19366218289793,-5.26855245864028,-0.402582784015351,"RAB5A","RAB5A, member RAS oncogene family",TRUE
+"240990_at",0.893462835798285,0.568379639148093,0.579075001707839,-5.77766429806827,0.232397710240616,"RAB5A","RAB5A, member RAS oncogene family",TRUE
+"201276_at",0.55937703282623,0.0537667555168414,-2.03703715582585,-4.09847202619066,-0.625272797659111,"RAB5B","RAB5B, member RAS oncogene family",TRUE
+"201156_s_at",0.912329443373872,0.632665740218079,0.484672394152968,-5.82591194020713,0.194786564174068,"RAB5C","RAB5C, member RAS oncogene family",TRUE
+"201140_s_at",0.940227139261806,0.732886469277813,0.345622429907423,-5.88166831363588,0.163982579062811,"RAB5C","RAB5C, member RAS oncogene family",TRUE
+"1559174_at",0.504296150624907,0.0327250615897059,2.27795385718951,-3.68612119161358,1.485949985134,"RAB6A","RAB6A, member RAS oncogene family",TRUE
+"221792_at",0.79943091106207,0.334268676830452,0.987063456823659,-5.47596536829056,0.324660194231717,"RAB6B","RAB6B, member RAS oncogene family",TRUE
+"225259_at",0.842928408549809,0.436846587140161,0.791845726238547,-5.63881454151774,0.486592792760976,"RAB6B","RAB6B, member RAS oncogene family",TRUE
+"210127_at",0.900949555002398,0.597057251511695,0.536355709560768,-5.80052945732799,0.356644187927957,"RAB6B","RAB6B, member RAS oncogene family",TRUE
+"217267_s_at",0.189446651755721,0.00189533275739148,3.52405244490724,-1.2199269702443,2.18951877277081,"RAB7A","RAB7A, member RAS oncogene family",TRUE
+"1570061_at",0.774230543658252,0.288455530275175,-1.08761429446736,-5.3793941589147,-0.322300502576608,"RAB7A","RAB7A, member RAS oncogene family",TRUE
+"211961_s_at",0.801285128907773,0.337983313084062,-0.979343559034706,-5.48302916531159,-0.276254791181152,"RAB7A","RAB7A, member RAS oncogene family",TRUE
+"223760_s_at",0.827271467184588,0.396016023971143,-0.865543532023802,-5.5812350240926,-0.364026810046377,"RAB7A","RAB7A, member RAS oncogene family",TRUE
+"227602_at",0.831875452294783,0.407608542738172,0.844148816562371,-5.5984435226658,0.277899293565067,"RAB7A","RAB7A, member RAS oncogene family",TRUE
+"211960_s_at",0.838610044014507,0.423738190253802,-0.815014997827737,-5.62122952103075,-0.215924564096239,"RAB7A","RAB7A, member RAS oncogene family",TRUE
+"217268_at",0.952082954955992,0.780869464051422,0.281592167760193,-5.90113585142274,0.289315607929824,"RAB7A","RAB7A, member RAS oncogene family",TRUE
+"230266_at",0.926263798296325,0.679785298041853,-0.418257034551834,-5.85483450752848,-0.244810237531454,"RAB7B","RAB7B, member RAS oncogene family",TRUE
+"1553982_a_at",0.938335759577472,0.726141502892731,-0.354736083074011,-5.878577751212,-0.261562469097804,"RAB7B","RAB7B, member RAS oncogene family",TRUE
+"208819_at",0.975265330414469,0.880337246321512,-0.152289014041208,-5.92839384905685,-0.0522952438277571,"RAB8A","RAB8A, member RAS oncogene family",TRUE
+"226633_at",0.822862741321714,0.388683185320066,-0.879285922690846,-5.56997033174454,-0.480336939307122,"RAB8B","RAB8B, member RAS oncogene family",TRUE
+"219210_s_at",0.955841603889187,0.798973442724163,0.257756903787204,-5.9073753866417,0.130516189606297,"RAB8B","RAB8B, member RAS oncogene family",TRUE
+"222846_at",0.974849253960767,0.876660047896534,-0.157008566260726,-5.92768367944967,-0.0860901861063663,"RAB8B","RAB8B, member RAS oncogene family",TRUE
+"221808_at",0.835952408568777,0.416055894261005,-0.828802022613654,-5.61053979828568,-0.260233430546331,"RAB9A","RAB9A, member RAS oncogene family",TRUE
+"222918_at",0.756006545489432,0.250834784459265,-1.1791784097956,-5.28422411687266,-1.14101147075335,"RAB9B","RAB9B, member RAS oncogene family",TRUE
+"208245_at",0.819018525257656,0.374629515471114,0.906104090471238,-5.5475140250889,0.777440419868367,"RAB9BP1","RAB9B, member RAS oncogene family pseudogene 1",TRUE
+"203136_at",0.609970971583967,0.0820129264530883,-1.82180670958757,-4.44076613657823,-0.814902103641611,"RABAC1","Rab acceptor 1",TRUE
+"203223_at",0.602806347163336,0.0773312065661388,-1.85244520164553,-4.39367146381843,-0.762364157843642,"RABEP1","rabaptin, RAB GTPase binding effector protein 1",TRUE
+"214552_s_at",0.754965837630846,0.248493190928298,-1.18520463051436,-5.277723923802,-0.410251915516595,"RABEP1","rabaptin, RAB GTPase binding effector protein 1",TRUE
+"225092_at",0.86376638668979,0.489411985272647,0.702943012545018,-5.7018354227763,0.2795473658541,"RABEP1","rabaptin, RAB GTPase binding effector protein 1",TRUE
+"231002_s_at",0.986455005400648,0.936900909588716,-0.0800693578786361,-5.93656135166874,-0.0224899201273221,"RABEP1","rabaptin, RAB GTPase binding effector protein 1",TRUE
+"225064_at",0.986455005400648,0.936981019331609,0.079967476040269,-5.93656929070832,0.0329975470566506,"RABEP1","rabaptin, RAB GTPase binding effector protein 1",TRUE
+"219057_at",0.1458024867988,0.00100268376838315,-3.78702136730483,-0.658940209488121,-1.98851038349204,"RABEP2","rabaptin, RAB GTPase binding effector protein 2",TRUE
+"74694_s_at",0.606339206711271,0.0799935893491252,-1.83483052273243,-4.42081579083043,-0.817353787331379,"RABEP2","rabaptin, RAB GTPase binding effector protein 2",TRUE
+"77508_r_at",0.997171203405,0.985658472961934,-0.018179373278523,-5.93952251272572,-0.00549494486826596,"RABEP2","rabaptin, RAB GTPase binding effector protein 2",TRUE
+"203150_at",0.937842878751575,0.724821903166534,-0.356522660153624,-5.87796258241166,-0.135018060607528,"RABEPK","Rab9 effector protein with kelch motifs",TRUE
+"1558021_at",0.967701855457407,0.847986093115819,-0.193944945075559,-5.9213793643993,-0.0804921879145892,"RABEPK","Rab9 effector protein with kelch motifs",TRUE
+"213313_at",0.841346844002252,0.431683366645977,-0.800919628057798,-5.63198439298865,-0.289213406155149,"RABGAP1","RAB GTPase activating protein 1",TRUE
+"204028_s_at",0.864894115958506,0.493320509913783,-0.696562032964849,-5.70608457362091,-0.266839297847737,"RABGAP1","RAB GTPase activating protein 1",TRUE
+"215070_x_at",0.879761308185056,0.534558224727988,0.630903276169722,-5.7476510265669,0.424059930814001,"RABGAP1","RAB GTPase activating protein 1",TRUE
+"213982_s_at",0.050114022740896,6.56592412498174e-05,4.90148630182421,1.740871182918,2.43366730091863,"RABGAP1L","RAB GTPase activating protein 1 like",TRUE
+"1554725_at",0.566552750683806,0.0570129587875264,2.00778633580709,-4.14651559094235,0.652648535251885,"RABGAP1L","RAB GTPase activating protein 1 like",TRUE
+"203020_at",0.646692716816097,0.117720544778941,1.62772902428632,-4.72555115302845,0.896777666467603,"RABGAP1L","RAB GTPase activating protein 1 like",TRUE
+"215342_s_at",0.704148059811236,0.176071805784608,1.3975982441811,-5.03061643601574,1.16587413804803,"RABGAP1L","RAB GTPase activating protein 1 like",TRUE
+"232702_at",0.872005986651814,0.514672628960271,0.662199623022105,-5.72832986053265,0.280938410891998,"RABGAP1L","RAB GTPase activating protein 1 like",TRUE
+"228110_x_at",0.708894565317004,0.1813429307855,-1.38003595664186,-5.05234487016152,-0.584680772481572,"RABGEF1","RAB guanine nucleotide exchange factor 1",TRUE
+"235407_at",0.934200936091995,0.708755444702536,-0.378371842854203,-5.87019251501509,-0.155575415441181,"RABGEF1","RAB guanine nucleotide exchange factor 1",TRUE
+"203573_s_at",0.83176405048326,0.406566000293391,-0.846056826082608,-5.59692515411947,-0.305491180589017,"RABGGTA","Rab geranylgeranyltransferase alpha subunit",TRUE
+"209180_at",0.762670173856783,0.262108820206555,1.15073617686343,-5.31451163368417,0.413832931262588,"RABGGTB","Rab geranylgeranyltransferase beta subunit",TRUE
+"204478_s_at",0.490163650763425,0.0292887909838886,-2.33031186982476,-3.5928390204585,-0.702376347321943,"RABIF","RAB interacting factor",TRUE
+"204477_at",0.67368843181164,0.140136943717199,-1.53013285991329,-4.85944423612297,-0.563403041620651,"RABIF","RAB interacting factor",TRUE
+"219151_s_at",0.897699110987203,0.585143214832128,-0.55397640968274,-5.79130409885077,-0.24564019705864,"RABL2A///RABL2B","RAB, member of RAS oncogene family-like 2A///RAB, member of RAS oncogene family-like 2B",TRUE
+"220500_s_at",0.936992192746977,0.718068105977966,-0.365685164906941,-5.87475971308093,-0.144415937081117,"RABL2A///RABL2B","RAB, member of RAS oncogene family-like 2A///RAB, member of RAS oncogene family-like 2B",TRUE
+"226090_x_at",0.610455440146151,0.0831399894593629,-1.81465806194321,-4.45167324095562,-0.772238733243578,"RABL3","RAB, member of RAS oncogene family like 3",TRUE
+"226089_at",0.722910301886587,0.19932094743375,-1.32302029656491,-5.12130378593429,-0.497172080298514,"RABL3","RAB, member of RAS oncogene family like 3",TRUE
+"213970_at",0.851733415458562,0.455945075930954,-0.758840896860541,-5.66303907295815,-0.283023411536318,"RABL3","RAB, member of RAS oncogene family like 3",TRUE
+"223166_x_at",0.499428826990278,0.0315138859642523,-2.29580738572884,-3.65445169070158,-0.694415434796355,"RABL6","RAB, member RAS oncogene family-like 6",TRUE
+"227714_s_at",0.663789119801086,0.13165368121714,-1.56543014144543,-4.81176875275142,-1.13795780207459,"RABL6","RAB, member RAS oncogene family-like 6",TRUE
+"225377_at",0.714054210868775,0.189134578542325,-1.3548026664309,-5.08316392206678,-0.404967224063347,"RABL6","RAB, member RAS oncogene family-like 6",TRUE
+"219828_at",0.967701855457407,0.8482247438357,0.193636457959911,-5.9214374943187,0.0629309239099669,"RABL6","RAB, member RAS oncogene family-like 6",TRUE
+"1567457_at",0.620912785033482,0.0909466482517509,1.76732040578462,-4.52311258913728,0.511921289107326,"RAC1","ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)",TRUE
+"208641_s_at",0.724067243569133,0.201100372537411,1.31759947401821,-5.12773288026143,0.373193708813901,"RAC1","ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)",TRUE
+"208640_at",0.822850703882235,0.388143332322912,0.880304283611907,-5.56912902172835,0.216839799800495,"RAC1","ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)",TRUE
+"1567458_s_at",0.875938621758472,0.524185336191581,0.647147242333345,-5.73773473403373,0.199650662134772,"RAC1","ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)",TRUE
+"207419_s_at",0.372087370646208,0.0112493904650788,2.76508953406214,-2.77559853151083,3.93322446864367,"RAC2","ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)",TRUE
+"213603_s_at",0.382348164866486,0.0120763366683508,2.73372626815332,-2.83681068661294,4.06536765010266,"RAC2","ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)",TRUE
+"206103_at",0.725168361556674,0.203346727856406,-1.31080933968055,-5.13575452887181,-0.742656837924419,"RAC3","ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)",TRUE
+"222077_s_at",0.990810941805126,0.955545908297222,-0.0563781263457868,-5.9381354725101,-0.0155598547524303,"RACGAP1","Rac GTPase activating protein 1",TRUE
+"224272_at",0.64513208805899,0.116188585253424,1.63494952082699,-4.71539016508779,1.24618493732903,"RACGAP1P","Rac GTPase activating protein 1 pseudogene",TRUE
+"204460_s_at",0.588653540532996,0.06736735996146,1.92344660503443,-4.28240888331985,0.695343033222214,"RAD1","RAD1 checkpoint DNA exonuclease",TRUE
+"210216_x_at",0.597654932724127,0.0749430757829973,1.86870038354606,-4.36845872608927,0.618578772197708,"RAD1","RAD1 checkpoint DNA exonuclease",TRUE
+"228535_at",0.745508528302503,0.237062849073019,1.21524800266732,-5.24488772911838,0.419141073145411,"RAD1","RAD1 checkpoint DNA exonuclease",TRUE
+"204461_x_at",0.861320275790658,0.481598941951462,0.715787075234446,-5.6931705096394,0.267772136038523,"RAD1","RAD1 checkpoint DNA exonuclease",TRUE
+"235253_at",0.881970070870254,0.539128856430299,0.623799798138602,-5.75191119320156,0.257361272288957,"RAD1","RAD1 checkpoint DNA exonuclease",TRUE
+"211228_s_at",0.728385463227073,0.209566944447712,-1.29230677144939,-5.15743468195495,-0.441097071056973,"RAD17","RAD17 checkpoint clamp loader component",TRUE
+"207405_s_at",0.780674131139921,0.302417523503311,-1.05584245865596,-5.41081813737434,-0.369659369892235,"RAD17","RAD17 checkpoint clamp loader component",TRUE
+"210826_x_at",0.812302873476553,0.360795857965601,-0.933159802395417,-5.52422820392534,-0.30335913683961,"RAD17","RAD17 checkpoint clamp loader component",TRUE
+"224200_s_at",0.835223580564215,0.414289227341592,-0.831995191475586,-5.60804004934749,-0.3753941087024,"RAD18","RAD18, E3 ubiquitin protein ligase",TRUE
+"238670_at",0.840728383233774,0.429982721907933,-0.803923049456052,-5.62970753155679,-0.390583140031121,"RAD18","RAD18, E3 ubiquitin protein ligase",TRUE
+"223417_at",0.937271400689562,0.72199153913938,-0.360358628380348,-5.87663143756014,-0.15764537983782,"RAD18","RAD18, E3 ubiquitin protein ligase",TRUE
+"238748_at",0.98529096111871,0.927092793920129,0.0925500118031666,-5.93551240019218,0.0490909071978596,"RAD18","RAD18, E3 ubiquitin protein ligase",TRUE
+"200607_s_at",0.935414597731663,0.712831261353265,0.372811680474085,-5.87221308772808,0.167097767189347,"RAD21","RAD21 cohesin complex component",TRUE
+"200608_s_at",0.986249924471866,0.932540489154892,0.0856161863711244,-5.93611387457029,0.0236692237793275,"RAD21","RAD21 cohesin complex component",TRUE
+"215917_at",0.632949074657601,0.104128760309569,1.69477595491612,-4.62988216017305,1.54416700387919,"RAD21L1","RAD21 cohesin complex component like 1",TRUE
+"234662_at",0.748129799058101,0.240058330035214,-1.20727117036564,-5.25367568390159,-1.24457254487992,"RAD21L1","RAD21 cohesin complex component like 1",TRUE
+"201039_s_at",0.540483367247649,0.0450432368791638,2.1242731714139,-3.95250668989795,0.659413180334912,"RAD23A","RAD23 homolog A, nucleotide excision repair protein",TRUE
+"201046_s_at",0.740668810029442,0.230836699092852,1.23207492504583,-5.2261856326604,0.34694897271714,"RAD23A","RAD23 homolog A, nucleotide excision repair protein",TRUE
+"201222_s_at",0.830635993561085,0.404422338964378,-0.849989881511566,-5.59378519152374,-0.253724919036161,"RAD23B","RAD23 homolog B, nucleotide excision repair protein",TRUE
+"214422_at",0.868397087637799,0.503633931998746,0.679861839427711,-5.7170302202653,0.740780921813494,"RAD23B","RAD23 homolog B, nucleotide excision repair protein",TRUE
+"201223_s_at",0.899094059893116,0.58933210641883,-0.547761146874194,-5.79459118529772,-0.182308158403796,"RAD23B","RAD23 homolog B, nucleotide excision repair protein",TRUE
+"223598_at",0.929024902913511,0.687119660964681,-0.408096481152045,-5.85889059524892,-0.163240498595972,"RAD23B","RAD23 homolog B, nucleotide excision repair protein",TRUE
+"209349_at",0.505067985736837,0.032886023396514,-2.27562685952963,-3.69023822947307,-0.985801333643034,"RAD50","RAD50 double strand break repair protein",TRUE
+"238656_at",0.728385463227073,0.209574144747658,-1.29228560176669,-5.15745933747708,-0.5158170524759,"RAD50","RAD50 double strand break repair protein",TRUE
+"208393_s_at",0.80056683899707,0.336422897243716,-0.982579331066204,-5.48007454353281,-0.263961311242969,"RAD50","RAD50 double strand break repair protein",TRUE
+"205023_at",0.661974206478491,0.129526529713411,1.57457494684525,-4.79927742772654,0.713911604768835,"RAD51","RAD51 recombinase",TRUE
+"205024_s_at",0.945509858471469,0.754449200803929,0.316682184197455,-5.89095478520582,0.107726569583582,"RAD51","RAD51 recombinase",TRUE
+"1560081_at",0.617775129514679,0.0888511713249143,1.77967200336662,-4.50460497977397,1.4610246344179,"RAD51-AS1","RAD51 antisense RNA 1 (head to head)",TRUE
+"242518_at",0.984107964409733,0.921920620705378,0.0991374521811642,-5.93489764360883,0.0588596340542216,"RAD51-AS1","RAD51 antisense RNA 1 (head to head)",TRUE
+"204146_at",0.918041148686074,0.651656631369319,0.457654923212527,-5.83818076064126,0.182688231154412,"RAD51AP1","RAD51 associated protein 1",TRUE
+"216880_at",0.84899624366548,0.449630971723513,-0.769657949928002,-5.65520691419593,-0.549729445170308,"RAD51B","RAD51 paralog B",TRUE
+"1561122_a_at",0.984132887597385,0.922110959618704,-0.0988949527927831,-5.9349210226653,-0.0401778276825207,"RAD51B","RAD51 paralog B",TRUE
+"210255_at",0.991367768700244,0.959981255529322,0.0507477451188673,-5.93842920853115,0.0217759129449302,"RAD51B","RAD51 paralog B",TRUE
+"1554496_at",0.993687322844324,0.970314997335813,0.0376359380094167,-5.93899359699155,0.0198987417308176,"RAD51B","RAD51 paralog B",TRUE
+"209849_s_at",0.771011793494937,0.279899491148051,-1.10763486236008,-5.35916643407527,-0.685784596301705,"RAD51C","RAD51 paralog C",TRUE
+"206066_s_at",0.843475287501313,0.438574374684715,-0.788824065641336,-5.64107276603123,-0.536257779985174,"RAD51C","RAD51 paralog C",TRUE
+"37793_r_at",0.78885145722244,0.315142404981925,1.02778233472686,-5.4378750364082,0.357622937732527,"RAD51D","RAD51 paralog D",TRUE
+"209965_s_at",0.999858288848339,0.999547404698171,0.000573678503845791,-5.93968332045321,0.000162476981092396,"RAD51D","RAD51 paralog D",TRUE
+"1552649_a_at",0.695005304830231,0.16456553241279,-1.43744353652077,-4.9804807875059,-0.984648825301486,"RAD51L3-RFFL///RFFL","RAD51L3-RFFL readthrough///ring finger and FYVE-like domain containing E3 ubiquitin protein ligase",TRUE
+"1562603_at",0.818598668505758,0.372017162392899,0.91116181329721,-5.54320903669947,0.368026490997746,"RAD51L3-RFFL///RFFL","RAD51L3-RFFL readthrough///ring finger and FYVE-like domain containing E3 ubiquitin protein ligase",TRUE
+"228980_at",0.892625092437988,0.564994541819871,0.584188582903789,-5.77481355979207,0.226772294354273,"RAD51L3-RFFL///RFFL","RAD51L3-RFFL readthrough///ring finger and FYVE-like domain containing E3 ubiquitin protein ligase",TRUE
+"1552651_a_at",0.950784815723376,0.775287415443901,0.28897443410495,-5.89909232464862,0.111112409790219,"RAD51L3-RFFL///RFFL","RAD51L3-RFFL readthrough///ring finger and FYVE-like domain containing E3 ubiquitin protein ligase",TRUE
+"236880_at",0.467182928024826,0.024480081554898,2.41397732643344,-3.44128556579888,1.35575157035483,"RAD52","RAD52 homolog, DNA repair protein",TRUE
+"211904_x_at",0.727294834785485,0.207663026682484,1.29792437139064,-5.1508799584638,0.377835171018927,"RAD52","RAD52 homolog, DNA repair protein",TRUE
+"205647_at",0.937113154905832,0.720471004679565,-0.362421669318365,-5.87590971035477,-0.296302051795466,"RAD52","RAD52 homolog, DNA repair protein",TRUE
+"210630_s_at",0.955730092376044,0.797264830665144,0.259999694167291,-5.90681162089358,0.166672073078691,"RAD52","RAD52 homolog, DNA repair protein",TRUE
+"219494_at",0.74126098489332,0.23194317200832,-1.22905962586063,-5.2295532892093,-0.513846102855409,"RAD54B","RAD54 homolog B (S. cerevisiae)",TRUE
+"204558_at",0.899331416659389,0.589964924553497,-0.546824103863715,-5.79508363734977,-0.228100626561776,"RAD54L","RAD54-like (S. cerevisiae)",TRUE
+"226624_at",0.660093442228076,0.128105209406919,-1.58075500384575,-4.79080351386929,-0.670155198632669,"RAD54L2","RAD54-like 2 (S. cerevisiae)",TRUE
+"1557194_a_at",0.912241810302154,0.631871589355958,0.485810064639376,-5.8253802176063,0.249608865545724,"RAD54L2","RAD54-like 2 (S. cerevisiae)",TRUE
+"213205_s_at",0.923494952314901,0.671680079624368,0.429537854863504,-5.85021634740617,0.266522179901785,"RAD54L2","RAD54-like 2 (S. cerevisiae)",TRUE
+"204828_at",0.942427328086864,0.741280364181365,-0.334322211692368,-5.88538992895231,-0.129601268812698,"RAD9A","RAD9 checkpoint clamp component A",TRUE
+"1553285_s_at",0.512681169570718,0.0342701040360846,-2.25603621672174,-3.7248001368353,-1.89310246068712,"RAD9B","RAD9 checkpoint clamp component B",TRUE
+"1564688_a_at",0.910165867297668,0.626236229004434,0.493901888762276,-5.82156312936416,0.278064728635951,"RAD9B","RAD9 checkpoint clamp component B",TRUE
+"223693_s_at",0.976335130930535,0.885678557509384,-0.145439905549807,-5.9293859969537,-0.0992474914621004,"RADIL","Rap associating with DIL domain",TRUE
+"211318_s_at",0.686747966354964,0.155179406072114,-1.47164234548058,-4.93653349356729,-0.710756012637056,"RAE1","ribonucleic acid export 1",TRUE
+"201558_at",0.713330901550199,0.188199327935283,-1.35778762216759,-5.07954293770046,-0.660067336382205,"RAE1","ribonucleic acid export 1",TRUE
+"211319_at",0.788413816943444,0.31468376264813,-1.02877968699887,-5.43692459816439,-0.871052863366329,"RAE1","ribonucleic acid export 1",TRUE
+"1552777_a_at",0.979588787486838,0.902169590979228,-0.124337001694083,-5.93215643984258,-0.119594772367098,"RAET1E","retinoic acid early transcript 1E",TRUE
+"201244_s_at",0.61760967235709,0.0881006703880753,-1.78415678005382,-4.497861684245,-0.483657038200882,"RAF1","Raf-1 proto-oncogene, serine/threonine kinase",TRUE
+"1557675_at",0.923101832489914,0.670330316731682,-0.431421926859637,-5.84943327542012,-0.145200082483096,"RAF1","Raf-1 proto-oncogene, serine/threonine kinase",TRUE
+"1554994_at",0.88698237223329,0.551010185300125,0.605483332405863,-5.76268159398612,0.555730698495363,"RAG1","recombination activating gene 1",TRUE
+"206591_at",0.943294768503521,0.744900444362418,0.329462460712638,-5.8869528101372,0.277608420022187,"RAG1","recombination activating gene 1",TRUE
+"215117_at",0.967438733768155,0.847465269286327,-0.194618244579953,-5.92125217066223,-0.201613387155195,"RAG2","recombination activating gene 2",TRUE
+"1552558_a_at",0.77547560202111,0.292532313850707,1.07822535350599,-5.3887669775926,0.326242269897294,"RAI1","retinoic acid induced 1",TRUE
+"219830_at",0.798380352644836,0.33256721593939,-0.990619233068967,-5.47269481688457,-0.570107491185767,"RAI1","retinoic acid induced 1",TRUE
+"226143_at",0.890004377648073,0.558305809685846,0.594339280251387,-5.76908289479536,0.245561928568851,"RAI1","retinoic acid induced 1",TRUE
+"202052_s_at",0.710842845257879,0.184375533043612,1.37011482097984,-5.06451868682458,1.75101905231131,"RAI14","retinoic acid induced 14",TRUE
+"219440_at",0.69887421412603,0.170156061395123,-1.41781452653712,-5.00532381305382,-1.63991238409374,"RAI2","retinoic acid induced 2",TRUE
+"214435_x_at",0.769258076576208,0.276188759578086,1.11645588548452,-5.35015019251343,0.345599824560177,"RALA","RALA Ras like proto-oncogene A",TRUE
+"224880_at",0.974670398319743,0.876223371719592,-0.157569264929463,-5.92759787194037,-0.052183490730485,"RALA","RALA Ras like proto-oncogene A",TRUE
+"202101_s_at",0.965620759643697,0.839365951308352,-0.205100770334156,-5.91921526925089,-0.0619833254615223,"RALB","RALB Ras like proto-oncogene B",TRUE
+"202100_at",0.969882914559333,0.857036962480325,-0.182258704874757,-5.92351704230637,-0.0568246893961248,"RALB","RALB Ras like proto-oncogene B",TRUE
+"202844_s_at",0.249014722180944,0.00346593879432461,3.27167641401464,-1.75018415773383,1.34605261847616,"RALBP1","ralA binding protein 1",TRUE
+"226957_x_at",0.358427723880268,0.00988556536065541,2.82193909662558,-2.66386769292323,1.02162173894799,"RALBP1","ralA binding protein 1",TRUE
+"202845_s_at",0.521284646650221,0.0378509382204184,2.20851587509281,-3.80789023098066,0.875414547668255,"RALBP1","ralA binding protein 1",TRUE
+"213049_at",0.304824368772306,0.00595060015943718,-3.04197800364858,-2.22283199036544,-1.3349606017019,"RALGAPA1","Ral GTPase activating protein catalytic alpha subunit 1",TRUE
+"235524_at",0.774360462422895,0.290481056282342,1.08293761007747,-5.38407187637736,0.496297752351401,"RALGAPA1","Ral GTPase activating protein catalytic alpha subunit 1",TRUE
+"234923_at",0.808233282592165,0.350271507115962,-0.954212360782328,-5.50567378147057,-0.30367347930507,"RALGAPA1","Ral GTPase activating protein catalytic alpha subunit 1",TRUE
+"215162_at",0.929234395612144,0.689052585300469,0.405426036770455,-5.85994034804265,0.259429892113395,"RALGAPA1","Ral GTPase activating protein catalytic alpha subunit 1",TRUE
+"1566272_at",0.934513597971556,0.709495371775021,0.377361548772381,-5.87056185120531,0.3182700687042,"RALGAPA1","Ral GTPase activating protein catalytic alpha subunit 1",TRUE
+"214855_s_at",0.237644535895285,0.00310644855001452,-3.31774546821136,-1.65414379924084,-1.37392805803307,"RALGAPA1///RALGAPA1P1","Ral GTPase activating protein catalytic alpha subunit 1///Ral GTPase activating protein catalytic alpha subunit 1 pseudogene 1",TRUE
+"1566269_at",0.762729892034689,0.262216040790966,1.15047007003006,-5.3147919404966,0.939061276786654,"RALGAPA1///RALGAPA1P1","Ral GTPase activating protein catalytic alpha subunit 1///Ral GTPase activating protein catalytic alpha subunit 1 pseudogene 1",TRUE
+"1566271_x_at",0.956820331597905,0.804446584415044,-0.250581670081123,-5.90914640746264,-0.195532328344038,"RALGAPA1///RALGAPA1P1","Ral GTPase activating protein catalytic alpha subunit 1///Ral GTPase activating protein catalytic alpha subunit 1 pseudogene 1",TRUE
+"231826_at",0.883190352125328,0.54106647858116,0.620798180587865,-5.75369738977757,0.372516255798221,"RALGAPA2","Ral GTPase activating protein catalytic alpha subunit 2",TRUE
+"225499_at",0.891249845423426,0.560554178041532,-0.59092021573779,-5.7710238183589,-0.210250357108624,"RALGAPA2","Ral GTPase activating protein catalytic alpha subunit 2",TRUE
+"232500_at",0.933599541599416,0.706006102104183,0.382129312402532,-5.86881033972947,0.162483670300539,"RALGAPA2","Ral GTPase activating protein catalytic alpha subunit 2",TRUE
+"234314_at",0.955645941042265,0.796701611391508,0.26073929576413,-5.90662464476734,0.223619742956963,"RALGAPA2","Ral GTPase activating protein catalytic alpha subunit 2",TRUE
+"239660_at",0.958770864245184,0.812995606916053,0.239400678862764,-5.91180707466089,0.107013978341086,"RALGAPA2","Ral GTPase activating protein catalytic alpha subunit 2",TRUE
+"221738_at",0.789795896476304,0.317854363239064,-1.02190570135043,-5.44345833839548,-0.434120657062344,"RALGAPB","Ral GTPase activating protein non-catalytic beta subunit",TRUE
+"221736_at",0.7974001826642,0.330671403069852,-0.994595996035798,-5.46902438428292,-0.423712134404111,"RALGAPB","Ral GTPase activating protein non-catalytic beta subunit",TRUE
+"224678_at",0.988164716416515,0.943558488994378,-0.0716052481404717,-5.93718646486509,-0.0302799524586117,"RALGAPB","Ral GTPase activating protein non-catalytic beta subunit",TRUE
+"209051_s_at",0.634499515855866,0.105558437973936,-1.6873864776182,-4.64056978278419,-0.717841780224969,"RALGDS","ral guanine nucleotide dissociation stimulator",TRUE
+"209050_s_at",0.868361060481977,0.502942655734481,-0.680975101257477,-5.71630846253538,-0.280669017036084,"RALGDS","ral guanine nucleotide dissociation stimulator",TRUE
+"204199_at",0.545083406296189,0.0468866439837398,-2.10464713135568,-3.9856889121851,-1.99887237000521,"RALGPS1","Ral GEF with PH domain and SH3 binding motif 1",TRUE
+"242689_at",0.823073978212882,0.388988365374743,0.878710648319533,-5.5704451902886,0.682663211218438,"RALGPS1","Ral GEF with PH domain and SH3 binding motif 1",TRUE
+"1554745_at",0.86219003266709,0.485127062333397,-0.709972290661767,-5.69711181508806,-0.39189341601829,"RALGPS1","Ral GEF with PH domain and SH3 binding motif 1",TRUE
+"210552_s_at",0.943988850936011,0.749089495461951,-0.323848972900936,-5.88872990080333,-0.166427185973061,"RALGPS1","Ral GEF with PH domain and SH3 binding motif 1",TRUE
+"1555452_at",0.970643058558138,0.86019074194059,0.17819280859757,-5.92422974576716,0.0552072156064778,"RALGPS1","Ral GEF with PH domain and SH3 binding motif 1",TRUE
+"220338_at",0.767011398042819,0.268616020076147,1.13472941833832,-5.33127097289418,0.437550276531785,"RALGPS2","Ral GEF with PH domain and SH3 binding motif 2",TRUE
+"242458_at",0.83633038614858,0.417663506665943,0.825903763932972,-5.6128008918714,0.339071631814349,"RALGPS2","Ral GEF with PH domain and SH3 binding motif 2",TRUE
+"227224_at",0.924931811669372,0.675176551109436,0.424664611062494,-5.85222618222946,0.192806199193319,"RALGPS2","Ral GEF with PH domain and SH3 binding motif 2",TRUE
+"232112_at",0.972438691973544,0.867214429677137,-0.169148702817501,-5.92575757985761,-0.0687620156399227,"RALGPS2","Ral GEF with PH domain and SH3 binding motif 2",TRUE
+"227533_at",0.987487323337591,0.941059460516144,-0.0747817241691692,-5.93696004158134,-0.0404797431926198,"RALGPS2","Ral GEF with PH domain and SH3 binding motif 2",TRUE
+"201271_s_at",0.963379172403332,0.832878210384802,0.213514449899888,-5.91750340362996,0.064943724985568,"RALY","RALY heterogeneous nuclear ribonucleoprotein",TRUE
+"230294_at",0.84571977676742,0.443307179459299,-0.780584271296548,-5.64718941009373,-0.409619415273039,"RALY-AS1","RALY antisense RNA 1",TRUE
+"213967_at",0.915353407558177,0.642912675249009,-0.470050393386356,-5.83263738751573,-0.444405120513042,"RALYL","RALY RNA binding protein-like",TRUE
+"204916_at",0.980009054680439,0.905841034452243,0.119647009947514,-5.93271337824575,0.0939931090197277,"RAMP1","receptor activity modifying protein 1",TRUE
+"205779_at",0.919354071504066,0.656810016436205,-0.450383538725081,-5.84136503288683,-0.399845232155126,"RAMP2","receptor activity modifying protein 2",TRUE
+"1564670_at",0.732407055411282,0.216768376235306,1.27140885058507,-5.18160622789219,0.496098130020759,"RAMP2-AS1","RAMP2 antisense RNA 1",TRUE
+"232731_x_at",0.919354071504066,0.6568348012546,-0.450348627382612,-5.84138020059253,-0.441258117032936,"RAMP2-AS1","RAMP2 antisense RNA 1",TRUE
+"205326_at",0.9116561917482,0.630635272919266,-0.487582460444071,-5.82454941023679,-0.400355497690965,"RAMP3","receptor (G protein-coupled) activity modifying protein 3",TRUE
+"200749_at",0.534566721281704,0.0424867392474717,-2.15272458608846,-3.90405753424889,-0.785850482691838,"RAN","RAN, member RAS oncogene family",TRUE
+"200750_s_at",0.953622331321215,0.786435396551985,-0.274247093730826,-5.90311699612109,-0.0704948974303772,"RAN","RAN, member RAS oncogene family",TRUE
+"221915_s_at",0.597654932724127,0.0750391187215734,1.86803799527848,-4.3694891761528,0.568009972326907,"RANBP1","RAN binding protein 1",TRUE
+"202482_x_at",0.958587459575795,0.812316419080306,-0.240287807770342,-5.91160038031752,-0.166915685002936,"RANBP1","RAN binding protein 1",TRUE
+"202483_s_at",0.985498770484702,0.929629915490043,-0.0893202067627285,-5.93579838965533,-0.0327702879405791,"RANBP1","RAN binding protein 1",TRUE
+"221809_at",0.419258213999957,0.017237795744691,-2.57448823701075,-3.14254097488654,-0.783382773838837,"RANBP10","RAN binding protein 10",TRUE
+"53987_at",0.813021318305036,0.362200098344399,-0.930382181521358,-5.52664784089186,-0.336654070103798,"RANBP10","RAN binding protein 10",TRUE
+"1558773_s_at",0.893462835798285,0.568369648845493,0.579090070237002,-5.77765593324861,0.212773454246996,"RANBP10","RAN binding protein 10",TRUE
+"232329_at",0.915843130476898,0.644884219117148,-0.467249060335782,-5.83390285833688,-0.319191009223102,"RANBP10","RAN binding protein 10",TRUE
+"219661_at",0.457531863501901,0.0227330900573583,-2.44818636045695,-3.37847048789503,-1.3477431336933,"RANBP17","RAN binding protein 17",TRUE
+"244198_at",0.970540753946729,0.859679972494485,-0.178851089225339,-5.92411544444084,-0.134515528157813,"RANBP17","RAN binding protein 17",TRUE
+"226922_at",0.7768734672127,0.294922920968147,-1.07276335279215,-5.39418620266406,-0.410056187077915,"RANBP2","RAN binding protein 2",TRUE
+"201712_s_at",0.812896635201594,0.361951796044951,-0.930872803645128,-5.52622093308229,-0.321084075005308,"RANBP2","RAN binding protein 2",TRUE
+"201711_x_at",0.939290937475152,0.72823238388208,0.351907690006322,-5.87954540335457,0.113085024381062,"RANBP2","RAN binding protein 2",TRUE
+"201713_s_at",0.993354935415366,0.968786491510005,0.0395748759380874,-5.93892068548422,0.0116144278821402,"RANBP2","RAN binding protein 2",TRUE
+"202640_s_at",0.512390413490819,0.0342343334335978,-2.25653335213977,-3.72392528317416,-0.784772856557013,"RANBP3","RAN binding protein 3",TRUE
+"208272_at",0.545864297007573,0.0471734577660866,2.10165613661409,-3.99072858168114,1.01917663673173,"RANBP3","RAN binding protein 3",TRUE
+"210120_s_at",0.679430772812099,0.146747105553509,-1.50382806922662,-4.894411292459,-0.421833368973031,"RANBP3","RAN binding protein 3",TRUE
+"202639_s_at",0.884769004468037,0.544720312243847,-0.615153502562571,-5.75703392562285,-0.246332277756016,"RANBP3","RAN binding protein 3",TRUE
+"1553147_at",0.86481525165637,0.4923710206156,-0.698109475351169,-5.70505751276256,-0.958316706496774,"RANBP3L","RAN binding protein 3 like",TRUE
+"213019_at",0.989524702314661,0.948899084806295,-0.0648193873474131,-5.93763726638855,-0.0374575900241894,"RANBP6","RAN binding protein 6",TRUE
+"202582_s_at",0.647518308302168,0.118380582193841,1.62464237722,-4.72988424505007,0.465732518118372,"RANBP9","RAN binding protein 9",TRUE
+"216125_s_at",0.765228531154075,0.265287691766182,1.14288051055877,-5.32276248019647,0.375819324306878,"RANBP9","RAN binding protein 9",TRUE
+"243108_at",0.828607509614823,0.399147114761767,0.859725704882778,-5.58595420612086,0.469158544143923,"RANBP9","RAN binding protein 9",TRUE
+"202583_s_at",0.882059205223864,0.539453394335023,0.623296646684161,-5.75221118651285,0.205409717246864,"RANBP9","RAN binding protein 9",TRUE
+"212127_at",0.588653540532996,0.0673369633798652,1.92367692833393,-4.28204321235612,0.590192892541534,"RANGAP1","Ran GTPase activating protein 1",TRUE
+"1553535_a_at",0.597654932724127,0.0747654467367008,1.86992740843518,-4.36654921236045,0.669485649924347,"RANGAP1","Ran GTPase activating protein 1",TRUE
+"212125_at",0.698391916012681,0.169499503820759,1.42009272017732,-5.00245483408274,0.526773187429786,"RANGAP1","Ran GTPase activating protein 1",TRUE
+"218526_s_at",0.610033432202476,0.0825992140210332,1.8180775067338,-4.44645985034954,1.59003537757972,"RANGRF","RAN guanine nucleotide release factor",TRUE
+"223554_s_at",0.65284137151906,0.121873468644956,1.60854388808734,-4.75238058046475,1.23641055313957,"RANGRF","RAN guanine nucleotide release factor",TRUE
+"1555339_at",0.522667179791589,0.0384589802072935,-2.20085603942531,-3.82118311145944,-1.26063321167554,"RAP1A","RAP1A, member of RAS oncogene family",TRUE
+"202362_at",0.774230543658252,0.286981204847084,-1.09103322381541,-5.3759631059702,-0.378190071371684,"RAP1A","RAP1A, member of RAS oncogene family",TRUE
+"228548_at",0.837337084923913,0.420054532515649,0.821606103095467,-5.61614008534089,0.327741814557517,"RAP1A","RAP1A, member of RAS oncogene family",TRUE
+"1555340_x_at",0.904381089098038,0.607437828331701,-0.521142004758144,-5.80826125893608,-0.293243800183991,"RAP1A","RAP1A, member of RAS oncogene family",TRUE
+"200833_s_at",0.829459856894727,0.400750097480221,-0.856758593128373,-5.58834959656083,-0.230376035633348,"RAP1B","RAP1B, member of RAS oncogene family",TRUE
+"203911_at",0.868910713861741,0.505342896742124,-0.677113340932871,-5.71880730968613,-0.477701837749064,"RAP1GAP","RAP1 GTPase activating protein",TRUE
+"210618_at",0.920295529438727,0.660653436148561,-0.444976536590469,-5.84370043599211,-0.378431136354047,"RAP1GAP","RAP1 GTPase activating protein",TRUE
+"213280_at",0.838294736493351,0.423027554829301,0.81628372328668,-5.62025283920038,0.552985322355619,"RAP1GAP2","RAP1 GTPase activating protein 2",TRUE
+"217457_s_at",0.801837936177267,0.339370870737084,-0.97647484005393,-5.48564119949975,-0.336000052393196,"RAP1GDS1","Rap1 GTPase-GDP dissociation stimulator 1",TRUE
+"237856_at",0.809652358091397,0.352909133868454,-0.948896480461322,-5.51039468477512,-0.58199347300311,"RAP1GDS1","Rap1 GTPase-GDP dissociation stimulator 1",TRUE
+"209444_at",0.913300726876965,0.636589848774517,-0.479060339109158,-5.82851705560709,-0.143126601634743,"RAP1GDS1","Rap1 GTPase-GDP dissociation stimulator 1",TRUE
+"229905_at",0.991249206045988,0.958969034357587,0.0520325384672761,-5.93836489933817,0.0222965949595135,"RAP1GDS1","Rap1 GTPase-GDP dissociation stimulator 1",TRUE
+"214103_s_at",0.554642754132296,0.0511168135862336,2.06210703653921,-4.05693146839755,0.929566631690184,"RAP2A","RAP2A, member of RAS oncogene family",TRUE
+"221830_at",0.832005556956182,0.40832565358583,0.84283820023521,-5.59948463994239,0.394874896565304,"RAP2A","RAP2A, member of RAS oncogene family",TRUE
+"1556808_at",0.93565329131222,0.713503239734264,0.371896131667645,-5.8725429699531,0.133001575629824,"RAP2A","RAP2A, member of RAS oncogene family",TRUE
+"1556809_a_at",0.98453870130544,0.924749567462145,0.0955338800240145,-5.93523916831865,0.0751286709669587,"RAP2A","RAP2A, member of RAS oncogene family",TRUE
+"225585_at",0.991794292967986,0.962135698198847,-0.0480134400854573,-5.93856072115162,-0.0246935569203774,"RAP2A","RAP2A, member of RAS oncogene family",TRUE
+"213923_at",0.185392143728903,0.001810296532074,3.54310664281694,-1.17952571976491,1.02264782773505,"RAP2B","RAP2B, member of RAS oncogene family",TRUE
+"227897_at",0.233834817057915,0.00301515401967682,3.33027107244466,-1.62796808749163,1.35755519008169,"RAP2B","RAP2B, member of RAS oncogene family",TRUE
+"238622_at",0.409937516868549,0.0158324993449638,2.61284692187972,-3.06970045402948,1.34638882931145,"RAP2B","RAP2B, member of RAS oncogene family",TRUE
+"214488_at",0.74258116020638,0.232845201839564,1.2266095290811,-5.23228445027965,1.20813468247874,"RAP2B","RAP2B, member of RAS oncogene family",TRUE
+"214487_s_at",0.886023097762234,0.548281077450898,0.609671914461464,-5.76024593452878,0.28885868643731,"RAP2B///RAP2A","RAP2B, member of RAS oncogene family///RAP2A, member of RAS oncogene family",TRUE
+"218668_s_at",0.592518526795544,0.0696392145073281,-1.90648523715993,-4.30925400208089,-0.826834091632898,"RAP2C","RAP2C, member of RAS oncogene family",TRUE
+"218669_at",0.632949074657601,0.104227650715665,-1.69426206464153,-4.63062655373885,-0.802051193267022,"RAP2C","RAP2C, member of RAS oncogene family",TRUE
+"240561_at",0.662855903464759,0.130775559906315,1.56919030749353,-4.80663947593932,1.27785700635092,"RAP2C-AS1","RAP2C antisense RNA 1",TRUE
+"226389_s_at",0.646750698976317,0.117813822781622,-1.62729193336929,-4.72616513447252,-0.93502497303389,"RAPGEF1","Rap guanine nucleotide exchange factor 1",TRUE
+"225738_at",0.823518986434235,0.390403827311079,-0.876046286855458,-5.57264071815513,-0.296449674302048,"RAPGEF1","Rap guanine nucleotide exchange factor 1",TRUE
+"204543_at",0.939976205834042,0.730148410610664,-0.349318394345015,-5.88042454404531,-0.314043731404625,"RAPGEF1","Rap guanine nucleotide exchange factor 1",TRUE
+"203097_s_at",0.731125330580444,0.214222730606286,-1.27873405345511,-5.17317177107847,-0.597458574467209,"RAPGEF2","Rap guanine nucleotide exchange factor 2",TRUE
+"215992_s_at",0.752055263300689,0.245210593120464,-1.19372447941368,-5.26848469288593,-0.849039241110528,"RAPGEF2","Rap guanine nucleotide exchange factor 2",TRUE
+"203096_s_at",0.811432370461795,0.355590664769357,-0.943519580776343,-5.51514518586792,-0.488335976652646,"RAPGEF2","Rap guanine nucleotide exchange factor 2",TRUE
+"238176_at",0.838287089408256,0.422999588654492,0.816333679664015,-5.62021435296612,0.664228078035203,"RAPGEF2","Rap guanine nucleotide exchange factor 2",TRUE
+"215987_at",0.954456115752166,0.791202569892884,-0.267968345784491,-5.90476931490736,-0.17423340579601,"RAPGEF2","Rap guanine nucleotide exchange factor 2",TRUE
+"210051_at",0.770075820151416,0.278777348597696,1.11029336220181,-5.35645577640496,1.14718382865182,"RAPGEF3","Rap guanine nucleotide exchange factor 3",TRUE
+"215027_at",0.80008362094922,0.335553995386248,-0.98438561217683,-5.4784213471718,-0.579823863831114,"RAPGEF3","Rap guanine nucleotide exchange factor 3",TRUE
+"205651_x_at",0.763650705722297,0.263544717712384,1.14717911992965,-5.31825378949757,0.992865737743442,"RAPGEF4","Rap guanine nucleotide exchange factor 4",TRUE
+"1563528_at",0.663848629163696,0.131956230484701,1.56413941950572,-4.81352720892822,0.572866789440809,"RAPGEF4-AS1","RAPGEF4 antisense RNA 1",TRUE
+"1563882_a_at",0.557589172116298,0.0524539741758211,2.04931535899755,-4.07816879695601,1.5160415411836,"RAPGEF5","Rap guanine nucleotide exchange factor 5",TRUE
+"204680_s_at",0.74413941468137,0.23489612440271,1.22106546027029,-5.23844712634457,0.351708590974507,"RAPGEF5","Rap guanine nucleotide exchange factor 5",TRUE
+"204681_s_at",0.818686885011389,0.372240793469584,0.910727927349652,-5.5435792152103,0.954411350607967,"RAPGEF5","Rap guanine nucleotide exchange factor 5",TRUE
+"1561269_at",0.8363408317442,0.417994505134742,0.825307901560304,-5.61326483858723,0.773670151677671,"RAPGEF5","Rap guanine nucleotide exchange factor 5",TRUE
+"230078_at",0.806248215548257,0.347084782206959,-0.960671227834005,-5.49990534089899,-0.31062232764517,"RAPGEF6","Rap guanine nucleotide exchange factor 6",TRUE
+"239438_at",0.816800680706682,0.368007028484988,0.918971769986798,-5.53651801444543,0.703323188051772,"RAPGEF6","Rap guanine nucleotide exchange factor 6",TRUE
+"219112_at",0.961395512423249,0.824875685066195,0.223914419427174,-5.91529273380066,0.0919734618674406,"RAPGEF6","Rap guanine nucleotide exchange factor 6",TRUE
+"1555247_a_at",0.985361089461736,0.927265620314926,-0.0923299688268149,-5.93553220651318,-0.0314513638626996,"RAPGEF6","Rap guanine nucleotide exchange factor 6",TRUE
+"218657_at",0.66003015172657,0.127805015387822,-1.5820675590351,-4.78900043303255,-2.35376076321053,"RAPGEFL1","Rap guanine nucleotide exchange factor like 1",TRUE
+"225188_at",0.513365264670114,0.03449271937191,-2.25295293979587,-3.73022348903147,-1.12753919030901,"RAPH1","Ras association (RalGDS/AF-6) and pleckstrin homology domains 1",TRUE
+"225189_s_at",0.514359473427819,0.0346293044661692,-2.25107017945062,-3.7335330079739,-1.07858179419742,"RAPH1","Ras association (RalGDS/AF-6) and pleckstrin homology domains 1",TRUE
+"1552482_at",0.721317419960934,0.197628439890531,-1.32821151200409,-5.11512615629672,-0.609812785153552,"RAPH1","Ras association (RalGDS/AF-6) and pleckstrin homology domains 1",TRUE
+"225186_at",0.742923871959998,0.233151320706271,-1.22577968357319,-5.23320842499636,-0.529421113590537,"RAPH1","Ras association (RalGDS/AF-6) and pleckstrin homology domains 1",TRUE
+"211570_s_at",0.930899509890345,0.694474823072252,0.397950815328806,-5.86284278172451,0.339913004238718,"RAPSN","receptor associated protein of the synapse",TRUE
+"203750_s_at",0.125870308684883,0.000750502434956962,-3.90591403329893,-0.403428797128004,-2.73010429428111,"RARA","retinoic acid receptor alpha",TRUE
+"203749_s_at",0.417905439947863,0.0170831030321623,-2.57856406372806,-3.13482661999305,-1.76291014916575,"RARA","retinoic acid receptor alpha",TRUE
+"211605_s_at",0.55498324465564,0.0512807563237365,-2.06052273046193,-4.05956649095658,-1.56526855788654,"RARA","retinoic acid receptor alpha",TRUE
+"1565358_at",0.740610299769501,0.230500923776169,1.23299213167705,-5.22515983260061,0.991308418523448,"RARA","retinoic acid receptor alpha",TRUE
+"216300_x_at",0.82706053436911,0.395722966982503,-0.86608957219126,-5.58079057903843,-0.825751002341731,"RARA","retinoic acid receptor alpha",TRUE
+"228037_at",0.816800680706682,0.368265561723735,0.918466561659929,-5.53695243387872,0.505102674700728,"RARA-AS1","RARA antisense RNA 1",TRUE
+"208413_at",0.670409852865276,0.136159085697967,1.54645784703582,-4.83750115276343,1.09795249053675,"RARB","retinoic acid receptor beta",TRUE
+"208412_s_at",0.675622576285316,0.142130971603726,1.52209243697952,-4.87018369523156,0.699305621034283,"RARB","retinoic acid receptor beta",TRUE
+"205080_at",0.711720858952053,0.185210139573293,1.36740709265094,-5.06782853371002,0.657014275476069,"RARB","retinoic acid receptor beta",TRUE
+"217020_at",0.771455545738152,0.280602403988928,1.10597351298058,-5.36085744947939,0.411977384414445,"RARB","retinoic acid receptor beta",TRUE
+"208530_s_at",0.877271158601418,0.526714967738468,0.643169817653568,-5.74018518967215,0.460559605422933,"RARB","retinoic acid receptor beta",TRUE
+"217178_at",0.915409740314202,0.64338189263309,-0.469383345038242,-5.83293939086783,-0.381035043939825,"RARG","retinoic acid receptor gamma",TRUE
+"204189_at",0.966773610653397,0.845492614792309,0.197169248312746,-5.920766273613,0.132815527527836,"RARG","retinoic acid receptor gamma",TRUE
+"204188_s_at",0.977909233665512,0.893344901580088,0.135621780183988,-5.93072876732259,0.0731945401377949,"RARG","retinoic acid receptor gamma",TRUE
+"206391_at",0.46481156911694,0.0239342388261445,2.42441604606169,-3.42216884351383,4.96944488581786,"RARRES1","retinoic acid receptor responder 1",TRUE
+"206392_s_at",0.562462825747979,0.0550992390435514,2.02484512051401,-4.1185530800531,4.86296716288495,"RARRES1","retinoic acid receptor responder 1",TRUE
+"221872_at",0.623667408398064,0.0950645117330444,1.74374367614633,-4.55817653830513,3.56491121079518,"RARRES1","retinoic acid receptor responder 1",TRUE
+"209496_at",0.839466826665106,0.425480382549408,0.811910209886002,-5.62361361836366,0.877797000091686,"RARRES2","retinoic acid receptor responder 2",TRUE
+"204070_at",0.728385463227073,0.209035934737861,1.29386955305373,-5.15561362228752,1.46524419507207,"RARRES3","retinoic acid receptor responder 3",TRUE
+"201330_at",0.768852835478002,0.273440466983557,-1.123044855134,-5.34337407363092,-0.535911471311332,"RARS","arginyl-tRNA synthetase",TRUE
+"207472_at",0.441719101781864,0.0204634033992755,2.4964749171844,-3.28899831265785,1.53621319723718,"RARS2","arginyl-tRNA synthetase 2, mitochondrial",TRUE
+"207471_at",0.723631474020681,0.200062430019143,1.32075688088896,-5.12399090367537,0.997597145553824,"RARS2","arginyl-tRNA synthetase 2, mitochondrial",TRUE
+"232901_at",0.789595899448337,0.31677718377263,1.02423565231406,-5.44124814593167,0.655683555880644,"RARS2","arginyl-tRNA synthetase 2, mitochondrial",TRUE
+"232902_s_at",0.812302873476553,0.35721047173721,0.940284845993253,-5.51799115005294,0.423122816480646,"RARS2","arginyl-tRNA synthetase 2, mitochondrial",TRUE
+"1561048_at",0.821424121108148,0.383361592288906,0.889364990909387,-5.56160385007809,0.336753776934233,"RARS2","arginyl-tRNA synthetase 2, mitochondrial",TRUE
+"225264_at",0.8552783609358,0.467589336522155,0.739125733312756,-5.6770439949433,0.311862216728461,"RARS2","arginyl-tRNA synthetase 2, mitochondrial",TRUE
+"210621_s_at",0.829519289742569,0.400960874061575,0.856369014430695,-5.58866353605556,0.391950608689731,"RASA1","RAS p21 protein activator 1",TRUE
+"202677_at",0.869971289491322,0.50783357938502,0.673116969422611,-5.72137894436738,0.303946487239402,"RASA1","RAS p21 protein activator 1",TRUE
+"206636_at",0.300116716920836,0.00562171304434417,3.0663409831957,-2.17324174058836,0.953807561265134,"RASA2","RAS p21 protein activator 2",TRUE
+"230669_at",0.327864702134751,0.00774762131061909,2.92818169220915,-2.45253295345339,0.815095052776096,"RASA2","RAS p21 protein activator 2",TRUE
+"226392_at",0.522667179791589,0.0384982803421373,2.20036474659087,-3.82203473753933,0.792665838606638,"RASA2","RAS p21 protein activator 2",TRUE
+"225562_at",0.728622545366091,0.210077838228643,1.29080608161789,-5.15918162795545,1.39704940946126,"RASA3","RAS p21 protein activator 3",TRUE
+"206220_s_at",0.863739823286196,0.489340143319765,0.703060573804489,-5.70175679106511,0.440535602394151,"RASA3","RAS p21 protein activator 3",TRUE
+"206221_at",0.916008366263392,0.645503787606776,0.466369510166341,-5.83429865749713,0.442070063924053,"RASA3","RAS p21 protein activator 3",TRUE
+"212707_s_at",0.616115851980985,0.087163349155426,1.78980439888626,-4.48935234200495,1.54164748060519,"RASA4B///RASA4CP///RASA4","RAS p21 protein activator 4B///RAS p21 protein activator 4C, pseudogene///RAS p21 protein activator 4",TRUE
+"208534_s_at",0.697589104334815,0.168123120764881,1.42489169158608,-4.99639901940393,1.72851120923501,"RASA4B///RASA4CP///RASA4","RAS p21 protein activator 4B///RAS p21 protein activator 4C, pseudogene///RAS p21 protein activator 4",TRUE
+"219752_at",0.809652358091397,0.3529299433085,0.948854648127251,-5.51043173922887,0.468890662781972,"RASAL1","RAS protein activator like 1",TRUE
+"233144_s_at",0.955645941042265,0.797032033107943,0.260305378507838,-5.90673440586574,0.141946139026319,"RASAL1","RAS protein activator like 1",TRUE
+"227036_at",0.468735421183467,0.0248390218050046,2.40722972490547,-3.45361856557219,1.48061586139793,"RASAL2","RAS protein activator like 2",TRUE
+"234343_s_at",0.51531387545335,0.0356883318185484,2.23669760235865,-3.75874253660644,1.08089150465617,"RASAL2","RAS protein activator like 2",TRUE
+"222810_s_at",0.515810181619652,0.0360572039535498,2.23178262971357,-3.76734114506429,1.64294798004018,"RASAL2","RAS protein activator like 2",TRUE
+"219026_s_at",0.54295328972902,0.0461290453949213,2.11262746497589,-3.97222005127258,1.37274966866169,"RASAL2","RAS protein activator like 2",TRUE
+"217201_at",0.595936234743389,0.0724114795183516,1.88643327260558,-4.34077675928333,1.51074169127056,"RASAL2","RAS protein activator like 2",TRUE
+"217194_at",0.660361499778769,0.12832813781709,1.57978193384844,-4.79213948222281,1.75627525788838,"RASAL2","RAS protein activator like 2",TRUE
+"1557432_at",0.685154158710982,0.153691934928079,1.47721482358975,-4.92929324276093,1.41793949289291,"RASAL2","RAS protein activator like 2",TRUE
+"234910_at",0.975264168529991,0.879994192780221,0.152729159508556,-5.92832853290758,0.0821867683856743,"RASAL2","RAS protein activator like 2",TRUE
+"228677_s_at",0.92070400963176,0.662489037966941,0.442398931165843,-5.84480402007163,0.259231426693012,"RASAL3","RAS protein activator like 3",TRUE
+"223467_at",0.911822480969241,0.631012843391554,0.487041003831128,-5.82480353075725,0.618000428784871,"RASD1","ras related dexamethasone induced 1",TRUE
+"223634_at",0.90344422113846,0.604117671209375,0.525994302931772,-5.80581877998585,0.459143906946488,"RASD2","RASD family member 2",TRUE
+"1553185_at",0.917102138198416,0.649512267914438,0.460687976973213,-5.83683775938434,0.249825547764061,"RASEF","RAS and EF-hand domain containing",TRUE
+"243862_at",0.934784679606929,0.710435292786256,-0.376078759954654,-5.87102940055696,-0.23970540093519,"RASEF","RAS and EF-hand domain containing",TRUE
+"1553986_at",0.966641191718519,0.845003096863355,0.197802491391908,-5.92064468132862,0.207739815194911,"RASEF","RAS and EF-hand domain containing",TRUE
+"1553186_x_at",0.973071267819624,0.870285449381398,-0.1651988589736,-5.92639994002495,-0.089834301695852,"RASEF","RAS and EF-hand domain containing",TRUE
+"235144_at",0.989586772349659,0.949237390202291,0.064389638647944,-5.93766430630336,0.108497567903507,"RASEF","RAS and EF-hand domain containing",TRUE
+"242917_at",0.90344422113846,0.604129839267855,0.525976496433095,-5.80582778345693,0.579901223408012,"RASGEF1A","RasGEF domain family member 1A",TRUE
+"230563_at",0.964181293782946,0.835566558340495,0.210026166440645,-5.91822145275914,0.404888561196571,"RASGEF1A","RasGEF domain family member 1A",TRUE
+"1553785_at",0.77204612088057,0.282254567024813,1.10208044743393,-5.36481120076363,0.891431638316176,"RASGEF1B","RasGEF domain family member 1B",TRUE
+"1554999_at",0.97928472590149,0.899895515137454,-0.127243388163577,-5.93180057568255,-0.0821656764198155,"RASGEF1B","RasGEF domain family member 1B",TRUE
+"236748_at",0.868397087637799,0.503813126495651,-0.679573397482245,-5.71721704077388,-0.395817428015248,"RASGEF1C","RasGEF domain family member 1C",TRUE
+"210550_s_at",0.501591596209182,0.0321948704582725,2.2856934949876,-3.67241003724684,2.46161050643864,"RASGRF1","Ras protein specific guanine nucleotide releasing factor 1",TRUE
+"215688_at",0.552219546148602,0.0494396831897102,2.07858105869339,-4.0294537934384,0.714202395747681,"RASGRF1","Ras protein specific guanine nucleotide releasing factor 1",TRUE
+"214905_at",0.720507507563255,0.196599013116118,1.33138596661262,-5.1113384713858,0.75441472511589,"RASGRF1","Ras protein specific guanine nucleotide releasing factor 1",TRUE
+"1554992_at",0.838514128856337,0.423574242796217,0.815307581511848,-5.62100441257041,0.503877212609216,"RASGRF1","Ras protein specific guanine nucleotide releasing factor 1",TRUE
+"228109_at",0.728671251879936,0.210228944318882,-1.29036276647215,-5.15969735894989,-0.860445974769495,"RASGRF2","Ras protein specific guanine nucleotide releasing factor 2",TRUE
+"1556128_a_at",0.847797601020174,0.447320141360667,-0.77363972706783,-5.65229752068561,-0.503940389888147,"RASGRF2","Ras protein specific guanine nucleotide releasing factor 2",TRUE
+"205590_at",0.712962773886379,0.187189403184983,-1.36102407139687,-5.07560935375303,-1.70775769768711,"RASGRP1","RAS guanyl releasing protein 1",TRUE
+"214369_s_at",0.696768332666858,0.16653623358556,1.43046389994751,-4.98934645432296,0.533890978906407,"RASGRP2","RAS guanyl releasing protein 2",TRUE
+"214368_at",0.844169896707408,0.440639757855443,0.785221576114217,-5.64375444546324,0.56323786344293,"RASGRP2","RAS guanyl releasing protein 2",TRUE
+"208206_s_at",0.956239592379877,0.801767330719575,0.254092441110974,-5.90828607232716,0.15474716810321,"RASGRP2","RAS guanyl releasing protein 2",TRUE
+"214367_at",0.961465118293157,0.825233380361432,-0.223449032765248,-5.91539389488277,-0.0940266276404218,"RASGRP2","RAS guanyl releasing protein 2",TRUE
+"205801_s_at",0.0552282326235679,0.000105052330916343,4.70892723376209,1.32870669544908,2.15734989824765,"RASGRP3","RAS guanyl releasing protein 3",TRUE
+"244526_at",0.952914447461733,0.784350530015414,0.276996557720268,-5.90238148504746,0.208203044571185,"RASGRP3","RAS guanyl releasing protein 3",TRUE
+"231328_s_at",0.877546037473893,0.528040845162944,0.64108926223207,-5.74146121896241,0.406137889708352,"RASGRP4","RAS guanyl releasing protein 4",TRUE
+"240862_at",0.9202957869034,0.66088437575585,-0.444652076379815,-5.8438396974748,-0.263244715513197,"RASGRP4","RAS guanyl releasing protein 4",TRUE
+"220027_s_at",0.296090407530139,0.0053454926528351,3.08788754420033,-2.12926967606095,2.27011680944471,"RASIP1","Ras interacting protein 1",TRUE
+"244830_at",0.973493137611142,0.872261971479794,-0.162658147948311,-5.9268051338067,-0.0566944279278587,"RASIP1","Ras interacting protein 1",TRUE
+"206850_at",0.722937902375896,0.19965334567601,-1.32200482158591,-5.12250983342887,-1.22724201773041,"RASL10A","RAS like family 10 member A",TRUE
+"244656_at",0.940044918888428,0.731651865886214,0.347288346816519,-5.88110931634522,0.200241278223658,"RASL10B","RAS like family 10 member B",TRUE
+"235488_at",0.980001024522674,0.904821918533774,-0.120948573390914,-5.93256096054522,-0.0635023239464205,"RASL10B","RAS like family 10 member B",TRUE
+"238353_at",0.978928101156583,0.89719195688691,0.13070013863432,-5.93136663557397,0.0518830353360658,"RASL11A","RAS like family 11 member A",TRUE
+"219142_at",0.599731655615302,0.076051388283375,-1.86110118385664,-4.3802649596679,-0.916247355726403,"RASL11B","RAS like family 11 member B",TRUE
+"234102_at",0.984410484401395,0.924040509930469,-0.0964369688747628,-5.93515476525733,-0.0602169078446382,"RASL11B","RAS like family 11 member B",TRUE
+"219167_at",0.957571530817866,0.808964829036185,0.244668427975939,-5.91056858371637,0.196886814064566,"RASL12","RAS like family 12",TRUE
+"204346_s_at",0.954178704842114,0.789520706119017,0.270182225290648,-5.90419104607249,0.257040171311129,"RASSF1","Ras association domain family member 1",TRUE
+"240278_at",0.778974960380281,0.300071196728104,-1.06110738630581,-5.40566851264702,-0.899179520337062,"RASSF1-AS1","RASSF1 antisense RNA 1",TRUE
+"238755_at",0.245363000968222,0.00330757931276124,3.2913687973166,-1.70917710039544,1.81305791583479,"RASSF10","Ras association domain family member 10",TRUE
+"203185_at",0.953817573907752,0.786779562564967,0.273793425329948,-5.90323765719451,0.208548261037856,"RASSF2","Ras association domain family member 2",TRUE
+"227167_s_at",0.885029460971826,0.545271226354891,-0.614304163893703,-5.75753342185505,-0.255928356504191,"RASSF3","Ras association domain family member 3",TRUE
+"233233_at",0.921312278448293,0.664759821940466,-0.439214436208203,-5.84615875144518,-0.217711392297124,"RASSF3","Ras association domain family member 3",TRUE
+"230466_s_at",0.921729477898827,0.666212273548731,-0.437179970994478,-5.84701921400226,-0.263312821270757,"RASSF3","Ras association domain family member 3",TRUE
+"226436_at",0.610033432202476,0.0823080304182395,1.81992676368992,-4.4436374709177,1.89752458560398,"RASSF4","Ras association domain family member 4",TRUE
+"49306_at",0.621733119678766,0.0920366296230484,1.76099202717,-4.53255837172904,1.60236015206377,"RASSF4","Ras association domain family member 4",TRUE
+"236287_at",0.807963535598932,0.349779466747148,0.955207018966654,-5.50478776792623,0.625606987781897,"RASSF4","Ras association domain family member 4",TRUE
+"237294_at",0.894543861393896,0.571199182240214,0.574827629428973,-5.78001369019503,0.284972488250243,"RASSF4","Ras association domain family member 4",TRUE
+"221578_at",0.943294768503521,0.745308114183603,0.328915696069684,-5.88712723079483,0.247080487160554,"RASSF4","Ras association domain family member 4",TRUE
+"223322_at",0.482017726238942,0.0274091103955532,2.36139135780793,-3.53689195907095,1.65051386347544,"RASSF5","Ras association domain family member 5",TRUE
+"1554834_a_at",0.67622507827427,0.142803116785276,1.51940304474582,-4.87376581517035,0.960154326207611,"RASSF5","Ras association domain family member 5",TRUE
+"235638_at",0.62110896023334,0.091494161124686,1.76413347992318,-4.52787252911697,1.46131415719334,"RASSF6","Ras association domain family member 6",TRUE
+"229147_at",0.673366993714442,0.139546012894764,1.53253369635829,-4.8562287595933,1.91486495119303,"RASSF6","Ras association domain family member 6",TRUE
+"233463_at",0.931941664456949,0.699171328650727,0.391494717810334,-5.86530670172611,0.396514056226544,"RASSF6","Ras association domain family member 6",TRUE
+"204927_at",0.749695948537086,0.2425765162427,-1.20062316535681,-5.26096131518436,-0.411349502961558,"RASSF7","Ras association domain family member 7",TRUE
+"40359_at",0.947778780715578,0.761475936194489,-0.307311813599773,-5.89378936412894,-0.0904191390011011,"RASSF7","Ras association domain family member 7",TRUE
+"235996_at",0.717385135322108,0.193192112162464,1.34198557391966,-5.09863624309457,0.779412272460496,"RASSF8","Ras association domain family member 8",TRUE
+"207754_at",0.755049574909504,0.249059078931152,1.1837444126964,-5.27930164452362,0.796374644747681,"RASSF8","Ras association domain family member 8",TRUE
+"225946_at",0.769847953580141,0.278213769999676,1.11163148775286,-5.3550892169082,0.68693041463893,"RASSF8","Ras association domain family member 8",TRUE
+"241735_at",0.782206338814045,0.30417932984614,1.05190820090368,-5.4146512264628,0.557157252869888,"RASSF8","Ras association domain family member 8",TRUE
+"242358_at",0.900750978800947,0.596300951429743,0.537469116862179,-5.79995510945388,0.402057365095656,"RASSF8-AS1","RASSF8 atnisense RNA 1",TRUE
+"235161_at",0.993083193605528,0.967160103090251,0.0416381506808674,-5.9388390773447,0.0289414889017738,"RASSF8-AS1","RASSF8 atnisense RNA 1",TRUE
+"241470_x_at",0.573831063059214,0.0603750339062185,1.97901225040811,-4.19332237973133,2.7154287310478,"RASSF9","Ras association domain family member 9",TRUE
+"210335_at",0.744688669253745,0.236116212242191,1.21778467054817,-5.24208261543283,0.624350189751452,"RASSF9","Ras association domain family member 9",TRUE
+"223425_at",0.717383438122835,0.193174538167909,1.34204062914311,-5.09857004599987,0.450280475716152,"RAVER1","ribonucleoprotein, PTB binding 1",TRUE
+"220680_at",0.591331966259927,0.0688581887431015,1.91226073844804,-4.30013152395794,1.16929103829919,"RAVER2","ribonucleoprotein, PTB binding 2",TRUE
+"231851_at",0.821187434813103,0.382460307870049,0.891081056808989,-5.56017056818639,0.715865608187774,"RAVER2","ribonucleoprotein, PTB binding 2",TRUE
+"208242_at",0.851733415458562,0.456030643484616,0.758694928330926,-5.6631440457458,0.27236269446915,"RAX","retina and anterior neural fold homeobox",TRUE
+"1552311_a_at",0.79810271372223,0.332305592645387,0.991167095739368,-5.47218994998465,0.64005162217144,"RAX2","retina and anterior neural fold homeobox 2",TRUE
+"211540_s_at",0.555180272174837,0.0513843644065277,-2.05952381938233,-4.06122720335922,-1.01672694506794,"RB1","RB transcriptional corepressor 1",TRUE
+"203132_at",0.646392036827936,0.117377832188622,-1.62933743720141,-4.7232907226296,-0.59934979776332,"RB1","RB transcriptional corepressor 1",TRUE
+"202033_s_at",0.933548873991014,0.705882001909118,0.382299049361876,-5.8687475845017,0.150653067417251,"RB1CC1","RB1 inducible coiled-coil 1",TRUE
+"202034_x_at",0.980264692225439,0.907823343013617,0.117115909593175,-5.93300506385807,0.0445551910963715,"RB1CC1","RB1 inducible coiled-coil 1",TRUE
+"241366_at",0.681231910132377,0.149122616943943,-1.49461151807971,-4.90654807630599,-0.611940510554358,"RBAK","RB associated KRAB zinc finger",TRUE
+"228571_at",0.704449222279154,0.176437634200105,-1.39636597055199,-5.03214844586435,-0.528374739402713,"RBAK","RB associated KRAB zinc finger",TRUE
+"1553122_s_at",0.737535792093258,0.223911414960329,-1.25120135507682,-5.2046587448638,-0.423397155076588,"RBAK","RB associated KRAB zinc finger",TRUE
+"230439_at",0.774230543658252,0.289887667801343,1.08430523211698,-5.38270581232081,0.718695442327974,"RBAKDN","RBAK downstream neighbor (non-protein coding)",TRUE
+"210371_s_at",0.755940660414394,0.250602988742837,-1.17977307131401,-5.28358397067311,-0.459303984609434,"RBBP4","RB binding protein 4, chromatin remodeling factor",TRUE
+"217301_x_at",0.779854829728531,0.301212052360175,-1.05854377186023,-5.4081788531441,-0.425672860688167,"RBBP4","RB binding protein 4, chromatin remodeling factor",TRUE
+"237333_at",0.806221445484273,0.346957129277175,0.9609307931524,-5.49967277813322,0.350766179756462,"RBBP4","RB binding protein 4, chromatin remodeling factor",TRUE
+"225396_at",0.920147736488699,0.659974398883338,0.445930836057739,-5.84329026377467,0.163619156344229,"RBBP4","RB binding protein 4, chromatin remodeling factor",TRUE
+"244872_at",0.950870395622221,0.775427093078339,0.28878951183132,-5.89914415463789,0.134786506731432,"RBBP4","RB binding protein 4, chromatin remodeling factor",TRUE
+"239071_at",0.982243328340126,0.914363435880286,0.108770687912185,-5.93392264881532,0.0317066956423098,"RBBP4","RB binding protein 4, chromatin remodeling factor",TRUE
+"205169_at",0.912241810302154,0.63202313445748,-0.485592916697026,-5.82548180196273,-0.180930303707919,"RBBP5","RB binding protein 5, histone lysine methyltransferase complex subunit",TRUE
+"1552329_at",0.423421354964585,0.017805214462728,-2.55982556968196,-3.17024255444963,-1.04229538097614,"RBBP6","RB binding protein 6, ubiquitin ligase",TRUE
+"212783_at",0.867447813467579,0.500015858691645,-0.685698157079175,-5.71323382438624,-0.184678992863434,"RBBP6","RB binding protein 6, ubiquitin ligase",TRUE
+"205178_s_at",0.878907265409251,0.532452703669217,-0.634186593140238,-5.74566623788874,-0.192522243568671,"RBBP6","RB binding protein 6, ubiquitin ligase",TRUE
+"212781_at",0.894729774938685,0.571869263844633,-0.573819786936377,-5.78056870932701,-0.150467868330214,"RBBP6","RB binding protein 6, ubiquitin ligase",TRUE
+"228814_at",0.931582451098271,0.697953155827408,-0.39316765380124,-5.86467204944525,-0.305057643228123,"RBBP6","RB binding protein 6, ubiquitin ligase",TRUE
+"223802_s_at",0.948882130664959,0.767366662816312,-0.299477962233811,-5.89609438816839,-0.15281697614823,"RBBP6","RB binding protein 6, ubiquitin ligase",TRUE
+"232044_at",0.953202153239013,0.784936692425727,-0.276223323554631,-5.90258906960562,-0.0670705839782828,"RBBP6","RB binding protein 6, ubiquitin ligase",TRUE
+"227635_at",0.993053762737399,0.966898672636626,-0.0419698245684366,-5.93882557193814,-0.0401138403265513,"RBBP6","RB binding protein 6, ubiquitin ligase",TRUE
+"201092_at",0.748237011093779,0.240770663646854,-1.20538530942546,-5.25574597104829,-0.349928808139646,"RBBP7","RB binding protein 7, chromatin remodeling factor",TRUE
+"203344_s_at",0.939976205834042,0.72997184886018,-0.349556895718534,-5.88034383421861,-0.126231980881347,"RBBP8","RB binding protein 8, endonuclease",TRUE
+"236258_at",0.707898177720919,0.179759136467752,-1.38526971359014,-5.0458933660504,-1.01995712723341,"RBBP8NL","RBBP8 N-terminal like",TRUE
+"221439_at",0.860313747871269,0.479761612667489,-0.718825030130056,-5.69109919314433,-0.637287808876405,"RBBP9","RB binding protein 9, serine hydrolase",TRUE
+"221440_s_at",0.913627134030439,0.637692878191821,0.477485657833604,-5.82924269128053,0.294017213160392,"RBBP9","RB binding protein 9, serine hydrolase",TRUE
+"232751_at",0.916042382946954,0.645713964705615,-0.4660712239481,-5.83443272101034,-0.24365805177695,"RBBP9","RB binding protein 9, serine hydrolase",TRUE
+"226696_at",0.984734424176794,0.925150179385922,0.0950236779654982,-5.93528650127699,0.0508071189016412,"RBBP9","RB binding protein 9, serine hydrolase",TRUE
+"221827_at",0.815028680506658,0.365903762702335,-0.923090640324762,-5.53296806313639,-0.318577299714988,"RBCK1","RANBP2-type and C3HC4-type zinc finger containing 1",TRUE
+"229920_at",0.879960488971225,0.53515067643842,0.62998067508833,-5.7482069613959,0.198316293486391,"RBCK1","RANBP2-type and C3HC4-type zinc finger containing 1",TRUE
+"207713_s_at",0.923004698880603,0.670046390634583,-0.431818448156416,-5.84926804150563,-0.193373996132225,"RBCK1","RANBP2-type and C3HC4-type zinc finger containing 1",TRUE
+"219419_at",0.676564076407042,0.143559145595825,-1.51639039416263,-4.87777249847688,-0.460690604133854,"RBFA","ribosome binding factor A (putative)",TRUE
+"243001_at",0.778580821633075,0.298671666698416,-1.06426177193925,-5.4025722098095,-0.366839211933567,"RBFA","ribosome binding factor A (putative)",TRUE
+"215683_at",0.382348164866486,0.0120798533110398,-2.73359728997015,-2.83706176934511,-1.10211640240111,"RBFADN","RBFA downstream neighbor (non-protein coding)",TRUE
+"1558628_at",0.863835356219448,0.489672916079506,-0.702516112201174,-5.70212085278957,-0.529276679272135,"RBFADN","RBFA downstream neighbor (non-protein coding)",TRUE
+"235070_at",0.587626678796111,0.0664820194522916,1.93019282459132,-4.27168577504857,1.04645663793183,"RBFOX1","RNA binding protein, fox-1 homolog 1",TRUE
+"1553422_s_at",0.697699759202153,0.168290419767398,1.4243066995399,-4.99713811668286,0.793546911886339,"RBFOX1","RNA binding protein, fox-1 homolog 1",TRUE
+"221217_s_at",0.776936981479994,0.295356838775705,1.07177535276903,-5.39516383717782,0.612133371936577,"RBFOX1","RNA binding protein, fox-1 homolog 1",TRUE
+"213901_x_at",0.427970909877547,0.0186060695524267,2.53985784359981,-3.20783812834086,0.986211149788444,"RBFOX2","RNA binding protein, fox-1 homolog 2",TRUE
+"212104_s_at",0.57460012602512,0.0605386351451386,1.97764864801808,-4.19552925179286,0.937564401503979,"RBFOX2","RNA binding protein, fox-1 homolog 2",TRUE
+"213898_at",0.673366993714442,0.139599042515291,1.53231790627388,-4.85651793427177,0.639372492678261,"RBFOX2","RNA binding protein, fox-1 homolog 2",TRUE
+"216215_s_at",0.731574335156004,0.215321023314166,1.2755654947994,-5.17682521828028,0.458552594884873,"RBFOX2","RNA binding protein, fox-1 homolog 2",TRUE
+"240975_x_at",0.508488499910913,0.0335770582435987,2.2657535396168,-3.70767892909602,1.38302793099781,"RBFOX3","RNA binding protein, fox-1 homolog 3",TRUE
+"235468_at",0.703902004301726,0.175438481463319,1.39973639527682,-5.02795555615041,0.842180097380226,"RBFOX3","RNA binding protein, fox-1 homolog 3",TRUE
+"229406_at",0.805746717966166,0.345546334740592,-0.963803794814517,-5.49709481866722,-0.511246422709986,"RBFOX3","RNA binding protein, fox-1 homolog 3",TRUE
+"57540_at",0.768852835478002,0.271941619584784,1.12665871291807,-5.33964259263784,0.522226107391604,"RBKS","ribokinase",TRUE
+"219222_at",0.818268955967428,0.37131912209755,0.912517254410016,-5.54205156704776,0.426830767243048,"RBKS","ribokinase",TRUE
+"1559307_s_at",0.850092661775655,0.452636443888667,0.764497744852609,-5.65895626248075,0.341994437190835,"RBL1","RB transcriptional corepressor like 1",TRUE
+"1555004_a_at",0.878278790222455,0.530938624368742,0.636551968222212,-5.74423021079736,0.434764994240094,"RBL1","RB transcriptional corepressor like 1",TRUE
+"1555003_at",0.947969282616012,0.763480453138462,-0.304643904684093,-5.89458099065047,-0.167152277670522,"RBL1","RB transcriptional corepressor like 1",TRUE
+"205296_at",0.959203345279235,0.815345571776125,-0.236332755484275,-5.91251601621171,-0.0960459721181373,"RBL1","RB transcriptional corepressor like 1",TRUE
+"212331_at",0.952789431929983,0.783868272719234,0.277632855146056,-5.90221023088002,0.117464243603431,"RBL2","RB transcriptional corepressor like 2",TRUE
+"212332_at",0.989823143387135,0.950791434248723,0.0624156978116105,-5.93778619761716,0.0303712550161457,"RBL2","RB transcriptional corepressor like 2",TRUE
+"217221_x_at",0.819780516863333,0.377492916405882,-0.900587017950796,-5.55218475618674,-0.233463278769918,"RBM10","RNA binding motif protein 10",TRUE
+"215089_s_at",0.834454640870101,0.412876608279813,-0.834554633894825,-5.6060299187719,-0.216048715680714,"RBM10","RNA binding motif protein 10",TRUE
+"208984_x_at",0.912705784586886,0.633774026770027,-0.483085788074789,-5.82665145055947,-0.126216749292896,"RBM10","RNA binding motif protein 10",TRUE
+"232549_at",0.83176405048326,0.406588157241053,0.846016243108934,-5.59695748280376,0.769150738799142,"RBM11","RNA binding motif protein 11",TRUE
+"212170_at",0.867307405402119,0.499572238103867,-0.68641540586908,-5.71276512997683,-0.306307139658506,"RBM12","RNA binding motif protein 12",TRUE
+"212168_at",0.91317690510462,0.635741485430311,-0.480272296233489,-5.82795697709151,-0.114770506083412,"RBM12","RNA binding motif protein 12",TRUE
+"238122_at",0.51470556386048,0.0349376339033009,-2.24684479082748,-3.74095438347694,-0.687325053529362,"RBM12B","RNA binding motif protein 12B",TRUE
+"51226_at",0.831957210365167,0.408151141634567,-0.843157009216074,-5.5992315259087,-0.466262899687479,"RBM12B","RNA binding motif protein 12B",TRUE
+"51228_at",0.88020017258149,0.535418781948905,-0.629563346154033,-5.74845817551122,-0.23748218134169,"RBM12B","RNA binding motif protein 12B",TRUE
+"220222_at",0.748184017928985,0.240413116546625,1.20633136820444,-5.25470774433211,0.380782337254969,"RBM12B-AS1","RBM12B antisense RNA 1",TRUE
+"239635_at",0.644844656970274,0.115104060642324,1.64010962114619,-4.70810748393083,0.609273791954913,"RBM14","RNA binding motif protein 14",TRUE
+"1555639_a_at",0.922168942129244,0.667673050768713,0.435135733396695,-5.84787985929656,0.168425808927285,"RBM14","RNA binding motif protein 14",TRUE
+"204178_s_at",0.96479405380661,0.837131485914633,0.207996814089798,-5.9186337678587,0.0577931789961283,"RBM14","RNA binding motif protein 14",TRUE
+"235511_at",0.653206225743412,0.122574363982909,1.60536007365605,-4.75680915427233,0.775145919751698,"RBM14-RBM4///RBM4","RBM14-RBM4 readthrough///RNA binding motif protein 4",TRUE
+"200997_at",0.872503767305084,0.51567594678956,-0.660604814120962,-5.72933613497057,-0.20899530508609,"RBM14-RBM4///RBM4","RBM14-RBM4 readthrough///RNA binding motif protein 4",TRUE
+"236157_at",0.910165867297668,0.626693601109094,-0.493243906569772,-5.8218758146119,-0.427822457678976,"RBM14-RBM4///RBM4","RBM14-RBM4 readthrough///RNA binding motif protein 4",TRUE
+"213718_at",0.944510229614013,0.750805735701586,0.321552217922052,-5.88944828145861,0.163813429847849,"RBM14-RBM4///RBM4","RBM14-RBM4 readthrough///RNA binding motif protein 4",TRUE
+"1555760_a_at",0.739367922105944,0.227202233164145,-1.2420573199826,-5.21498599705155,-0.340207742024791,"RBM15","RNA binding motif protein 15",TRUE
+"1555761_x_at",0.768852835478002,0.273059460178711,-1.12396212176232,-5.34242795589504,-0.325153208604421,"RBM15","RNA binding motif protein 15",TRUE
+"229291_at",0.775014733699535,0.291462326565125,-1.08068041196779,-5.38632313774276,-0.877028741115845,"RBM15","RNA binding motif protein 15",TRUE
+"219286_s_at",0.801587742916188,0.338923963830938,-0.977397922075558,-5.48480147429579,-0.217004467368726,"RBM15","RNA binding motif protein 15",TRUE
+"232971_at",0.871451481476429,0.512473441336961,-0.665701364529024,-5.72611221325625,-0.323350642922158,"RBM15","RNA binding motif protein 15",TRUE
+"228455_at",0.930527241884777,0.69264197463787,-0.400475020053061,-5.86186864579638,-0.215042536438085,"RBM15","RNA binding motif protein 15",TRUE
+"1555762_s_at",0.948962238903406,0.769739850628754,-0.296327376797177,-5.89700477645354,-0.088172641999618,"RBM15","RNA binding motif protein 15",TRUE
+"226987_at",0.484495305292367,0.027841091503689,-2.35407893749144,-3.55009311507157,-0.819328025476922,"RBM15B","RNA binding motif protein 15B",TRUE
+"202689_at",0.990810941805126,0.954568364782343,0.0576192981586954,-5.93806656854897,0.0167783719144374,"RBM15B","RNA binding motif protein 15B",TRUE
+"225751_at",0.645561742111595,0.116573042155789,1.63313000777665,-4.71795392081152,0.518090272240817,"RBM17","RNA binding motif protein 17",TRUE
+"221309_at",0.762690194692501,0.262180802951103,1.15055751666742,-5.31469983382352,0.683331333609768,"RBM17","RNA binding motif protein 17",TRUE
+"224781_s_at",0.832605695407954,0.409003254142395,0.841601140007636,-5.60046594083871,0.23195841674208,"RBM17","RNA binding motif protein 17",TRUE
+"224780_at",0.955892698633978,0.799694108314832,0.25681133583062,-5.90761161785515,0.103831401538876,"RBM17","RNA binding motif protein 17",TRUE
+"238963_at",0.641326159307468,0.111818625242739,-1.65599506756895,-4.68557735031599,-0.791191905362521,"RBM18","RNA binding motif protein 18",TRUE
+"225236_at",0.805177144722362,0.344470024548711,-0.966001016061963,-5.49511849466653,-0.276944992071764,"RBM18","RNA binding motif protein 18",TRUE
+"1555848_at",0.940567117317801,0.733931242714272,-0.344213439491852,-5.88213902534807,-0.109812319971457,"RBM18","RNA binding motif protein 18",TRUE
+"206019_at",0.727074488271062,0.207304329175265,-1.2989871890509,-5.14963712825389,-1.02184862083263,"RBM19","RNA binding motif protein 19",TRUE
+"205115_s_at",0.944793138991092,0.751741708194195,-0.320300398612809,-5.88983769493903,-0.097639862747755,"RBM19","RNA binding motif protein 19",TRUE
+"238763_at",0.76912869907427,0.274603686020966,-1.1202501915474,-5.34625242546678,-1.30758379979541,"RBM20","RNA binding motif protein 20",TRUE
+"218134_s_at",0.868541339434524,0.504617007468771,-0.67828013513128,-5.71805373972497,-0.219854558104783,"RBM22","RNA binding motif protein 22",TRUE
+"224068_x_at",0.913233126230689,0.63608227427426,-0.479785363628256,-5.82818216828679,-0.154182435498145,"RBM22","RNA binding motif protein 22",TRUE
+"222527_s_at",0.919354071504066,0.656856068783645,-0.45031867086865,-5.84139321468673,-0.171809743627685,"RBM22","RNA binding motif protein 22",TRUE
+"236872_at",0.952708776387501,0.78373910094846,-0.277803306164507,-5.90216428916883,-0.164397240183416,"RBM22","RNA binding motif protein 22",TRUE
+"219816_s_at",0.915353407558177,0.642861062753578,-0.470123779899529,-5.8326041364435,-0.144587023162558,"RBM23","RNA binding motif protein 23",TRUE
+"235004_at",0.94034618356165,0.733409827263273,0.344916535861746,-5.88190437442566,0.479304973255481,"RBM24","RNA binding motif protein 24",TRUE
+"212033_at",0.808233282592165,0.350326971333893,-0.954100299454868,-5.50577354958461,-0.280532178641369,"RBM25","RNA binding motif protein 25",TRUE
+"212031_at",0.871368516299129,0.512079411014308,-0.666329657827148,-5.72571313038467,-0.196945379262807,"RBM25","RNA binding motif protein 25",TRUE
+"212030_at",0.873230718105642,0.517857464615819,-0.657143141095417,-5.73151233643849,-0.211398953257941,"RBM25","RNA binding motif protein 25",TRUE
+"1557081_at",0.88482630320139,0.544942955787845,0.614810200408568,-5.757235901804,0.27041310448527,"RBM25","RNA binding motif protein 25",TRUE
+"236613_at",0.92051722798026,0.66206112918139,0.442999540347325,-5.84454743550642,0.212949120102422,"RBM25","RNA binding motif protein 25",TRUE
+"212027_at",0.960455930163982,0.82044982566637,-0.229676993668006,-5.91402277123796,-0.0692497193661641,"RBM25","RNA binding motif protein 25",TRUE
+"212028_at",0.990810941805126,0.954367397256235,-0.057874474933691,-5.93805221645826,-0.0176919106051248,"RBM25","RNA binding motif protein 25",TRUE
+"229433_at",0.527546822913581,0.0401778836682307,2.17978185675429,-3.85760888463991,0.681824128067355,"RBM26","RNA binding motif protein 26",TRUE
+"220509_at",0.575986890549489,0.0611053255358796,1.97295041766343,-4.20312504611564,0.732706840988182,"RBM26","RNA binding motif protein 26",TRUE
+"218422_s_at",0.697172073261335,0.167607020907413,1.42669927844388,-4.99411368578885,0.574697670676846,"RBM26","RNA binding motif protein 26",TRUE
+"226316_at",0.697699759202153,0.168242178545596,1.42447533604978,-4.99692508155788,0.631829787891078,"RBM26","RNA binding motif protein 26",TRUE
+"227355_at",0.719194150720157,0.195086757189404,1.33607300745037,-5.10573210635335,0.729283989466422,"RBM26","RNA binding motif protein 26",TRUE
+"222626_at",0.73957587762701,0.228198797738797,1.2393081439436,-5.21807817008652,0.374467735565611,"RBM26","RNA binding motif protein 26",TRUE
+"215751_at",0.906878681039516,0.615200340153692,0.509846348805668,-5.81386165109915,0.354514512095073,"RBM26","RNA binding motif protein 26",TRUE
+"233021_at",0.907964244160782,0.617760539076196,-0.506135622376735,-5.81567531882863,-0.298040365156816,"RBM26-AS1","RBM26 antisense RNA 1",TRUE
+"1568807_a_at",0.951339758531576,0.777347830272772,0.28624764539799,-5.89985325294867,0.238234898822826,"RBM26-AS1","RBM26 antisense RNA 1",TRUE
+"243295_at",0.623667408398064,0.0949081112058747,1.74462300155715,-4.55687502449159,0.503610883618157,"RBM27","RNA binding motif protein 27",TRUE
+"225326_at",0.886023097762234,0.548397968062688,-0.609492287978654,-5.76035071977755,-0.197771774135186,"RBM27","RNA binding motif protein 27",TRUE
+"218593_at",0.961212424803935,0.823103135083828,-0.226221379812302,-5.91478817741864,-0.0752572759237395,"RBM28","RNA binding motif protein 28",TRUE
+"222026_at",0.448867709549988,0.0213617518106826,-2.47679369427013,-3.32557681583792,-1.34621439263612,"RBM3","RNA binding motif (RNP1, RRM) protein 3",TRUE
+"208319_s_at",0.55937703282623,0.0538542251140665,-2.03622860731217,-4.09980622165229,-0.67933075231587,"RBM3","RNA binding motif (RNP1, RRM) protein 3",TRUE
+"1554095_at",0.615637099066718,0.0858235749766355,-1.797968532572,-4.47701675990097,-0.7157123147229,"RBM33","RNA binding motif protein 33",TRUE
+"238801_at",0.671298718565642,0.13727285537595,1.54184779535156,-4.84371640362768,0.375985720133148,"RBM33","RNA binding motif protein 33",TRUE
+"1554096_a_at",0.838305466071775,0.423206299748222,-0.815964477495109,-5.62049873299781,-0.314606850224151,"RBM33","RNA binding motif protein 33",TRUE
+"231834_at",0.865326415663012,0.494629468987243,0.694431532401838,-5.70749506053258,0.268608002542635,"RBM33","RNA binding motif protein 33",TRUE
+"226732_at",0.890944566293907,0.560101447327922,-0.591608104898393,-5.77063418950299,-0.145396655735665,"RBM33","RNA binding motif protein 33",TRUE
+"231833_at",0.940227139261806,0.732763750532244,0.345787976224916,-5.88161288358014,0.200054571988244,"RBM33","RNA binding motif protein 33",TRUE
+"225839_at",0.943294768503521,0.745015117329497,-0.329308651578267,-5.8870019050014,-0.1201404192366,"RBM33","RNA binding motif protein 33",TRUE
+"214942_at",0.712662349321242,0.186706456180658,1.36257661618359,-5.073719615716,0.481736165933119,"RBM34","RNA binding motif protein 34",TRUE
+"212430_at",0.908013878860707,0.61843510705921,-0.505159109831897,-5.81615045447626,-0.282104911188309,"RBM38","RNA binding motif protein 38",TRUE
+"207941_s_at",0.324623663332327,0.00742181597874079,-2.94679222069772,-2.41519360675157,-0.869108842377456,"RBM39","RNA binding motif protein 39",TRUE
+"208720_s_at",0.447294524001345,0.0212233468559476,-2.47977511278206,-3.32004551764503,-0.670406310422143,"RBM39","RNA binding motif protein 39",TRUE
+"226404_at",0.632949074657601,0.103805096773916,-1.69646079493576,-4.62744040029258,-0.795604069207694,"RBM39","RNA binding motif protein 39",TRUE
+"227223_at",0.928246500493356,0.684632821490691,-0.411536639937422,-5.85752827243416,-0.218851736919273,"RBM39","RNA binding motif protein 39",TRUE
+"227979_at",0.784898009367902,0.309422801900608,1.0402938826986,-5.42589184376462,0.577136352869829,"RBM4","RNA binding motif protein 4",TRUE
+"232860_x_at",0.864079461576774,0.491162643202228,0.700081319930088,-5.70374561956889,0.247106587808841,"RBM41","RNA binding motif protein 41",TRUE
+"219754_at",0.941400961503247,0.73805532769543,0.338658561895099,-5.88397625996814,0.12206095709648,"RBM41","RNA binding motif protein 41",TRUE
+"205740_s_at",0.728385463227073,0.209586686779669,-1.29224872814164,-5.15750228196256,-0.381474051014827,"RBM42","RNA binding motif protein 42",TRUE
+"228304_at",0.700061364939874,0.171379591266398,1.4135877071058,-5.01063671303007,0.600768872380338,"RBM43","RNA binding motif protein 43",TRUE
+"243038_at",0.994050962712312,0.972182334333946,0.0352673863558321,-5.93907769536697,0.0263847542309996,"RBM43","RNA binding motif protein 43",TRUE
+"228578_at",0.653375957820821,0.12278807437785,-1.60439231925505,-4.75815391752659,-0.403935352978069,"RBM45","RNA binding motif protein 45",TRUE
+"237702_at",0.864894115958506,0.493370534694815,0.69648055175361,-5.70613859366398,0.238540553702135,"RBM45","RNA binding motif protein 45",TRUE
+"242516_x_at",0.280199223932988,0.00468037389906961,-3.14452854618284,-2.01318332472795,-2.9021652516681,"RBM46","RNA binding motif protein 46",TRUE
+"244351_at",0.695744345349551,0.165588792480156,1.43381111676297,-4.98509915908366,1.42458044908514,"RBM46","RNA binding motif protein 46",TRUE
+"229440_at",0.835952408568777,0.416060266989432,-0.828794129740112,-5.61054596602254,-0.440360965308288,"RBM47","RNA binding motif protein 47",TRUE
+"222496_s_at",0.841346844002252,0.431698506526829,-0.800892923257688,-5.63200460169126,-0.539019434328107,"RBM47","RNA binding motif protein 47",TRUE
+"229439_s_at",0.859483694145165,0.47703263370968,-0.72334984520636,-5.68799864882315,-0.408323178942005,"RBM47","RNA binding motif protein 47",TRUE
+"218035_s_at",0.912246017248541,0.632286194406627,-0.48521603610043,-5.8256580057391,-0.356437639690645,"RBM47","RNA binding motif protein 47",TRUE
+"229421_s_at",0.954672574687803,0.793556865004944,0.264871621858308,-5.9055702566603,0.170878748397045,"RBM47","RNA binding motif protein 47",TRUE
+"221595_at",0.591331966259927,0.0686302207531184,-1.91395734755888,-4.29744806540496,-0.907676420677821,"RBM48","RNA binding motif protein 48",TRUE
+"221594_at",0.774501847131479,0.290932216486261,1.08189913492746,-5.38510814089122,0.40643292693297,"RBM48","RNA binding motif protein 48",TRUE
+"221596_s_at",0.801917957653237,0.339665610984923,-0.975866512797482,-5.48619419772553,-0.292642234467534,"RBM48","RNA binding motif protein 48",TRUE
+"232661_s_at",0.888084871936097,0.553560721272651,-0.601578668848073,-5.76493755712559,-0.216781608790024,"RBM48","RNA binding motif protein 48",TRUE
+"209497_s_at",0.682539393883246,0.150475876511087,1.48941455018114,-4.91336526116375,0.468750924117455,"RBM4B","RNA binding motif protein 4B",TRUE
+"201394_s_at",0.624374299616567,0.0959112956897642,-1.73900421600732,-4.5651831746348,-0.57269646378808,"RBM5","RNA binding motif protein 5",TRUE
+"201395_at",0.822819707575556,0.388035044978246,-0.880508664314194,-5.56896006554021,-0.291202564080949,"RBM5","RNA binding motif protein 5",TRUE
+"230742_at",0.948015976270656,0.763943957905968,0.304027325519679,-5.89476296990948,0.164596921299371,"RBM5","RNA binding motif protein 5",TRUE
+"209936_at",0.976371465776674,0.886170467983026,0.144809496987286,-5.92947502729186,0.112955310970405,"RBM5","RNA binding motif protein 5",TRUE
+"201967_at",0.623667408398064,0.0949043227871927,-1.74464431643783,-4.55684346972069,-0.518863952253128,"RBM6","RNA binding motif protein 6",TRUE
+"228030_at",0.764312283028184,0.264342865797583,-1.14520809572551,-5.32032299103922,-0.891129737695964,"RBM6","RNA binding motif protein 6",TRUE
+"1556672_a_at",0.871744769522775,0.513983844871775,0.663295469356353,-5.72763706779324,0.442345253871238,"RBM6","RNA binding motif protein 6",TRUE
+"218379_at",0.468735421183467,0.0250144688461343,2.40396430972941,-3.45958014086179,0.99492412681118,"RBM7","RNA binding motif protein 7",TRUE
+"235045_at",0.805746717966166,0.345540137998784,0.963816431724288,-5.4970834639642,0.469904803016664,"RBM7","RNA binding motif protein 7",TRUE
+"217857_s_at",0.551216488098096,0.0492994719122029,-2.07998089109497,-4.0271124205558,-1.04408111984833,"RBM8A","RNA binding motif protein 8A",TRUE
+"214113_s_at",0.615821255316333,0.0862838884232018,-1.79515121325718,-4.48127819295311,-0.747821606311261,"RBM8A","RNA binding motif protein 8A",TRUE
+"213852_at",0.673582826047901,0.139770576847077,-1.53162035386703,-4.85745248488566,-0.483594296002195,"RBM8A","RNA binding motif protein 8A",TRUE
+"217856_at",0.674667400429784,0.141010191453521,-1.52660021506693,-4.86416827481998,-0.556146464234216,"RBM8A","RNA binding motif protein 8A",TRUE
+"222443_s_at",0.75710709622615,0.252804478257605,-1.17414170982053,-5.28963475477453,-0.489002644486266,"RBM8A","RNA binding motif protein 8A",TRUE
+"1554602_at",0.845566619252464,0.442851458297221,0.781375330207996,-5.64660481009865,0.268048443141744,"RBM8A","RNA binding motif protein 8A",TRUE
+"225265_at",0.610033432202476,0.0826067926016862,1.81802945190832,-4.44653316520708,1.10509254317229,"RBMS1","RNA binding motif single stranded interacting protein 1",TRUE
+"207266_x_at",0.693634792246204,0.162638146447084,1.44433513269062,-4.97169238281568,1.03289814945821,"RBMS1","RNA binding motif single stranded interacting protein 1",TRUE
+"225269_s_at",0.698391916012681,0.169291870116615,1.42081466132841,-5.00154488883036,0.925626049261624,"RBMS1","RNA binding motif single stranded interacting protein 1",TRUE
+"203748_x_at",0.698391916012681,0.169607350217309,1.41971801850894,-5.00292696393096,0.967585479287976,"RBMS1","RNA binding motif single stranded interacting protein 1",TRUE
+"215127_s_at",0.726636642789909,0.20637712774357,1.30174110230293,-5.14641276330863,0.809613307975708,"RBMS1","RNA binding motif single stranded interacting protein 1",TRUE
+"209868_s_at",0.744863302188406,0.236387267804789,1.21705754892619,-5.24288720323865,0.819167882504017,"RBMS1","RNA binding motif single stranded interacting protein 1",TRUE
+"235439_at",0.348854934125219,0.00914998998813634,2.85577981005628,-2.59690000130436,2.1501470473395,"RBMS2","RNA binding motif single stranded interacting protein 2",TRUE
+"225778_at",0.492341486607851,0.0295574144372056,2.32602103933157,-3.60052978141253,2.3742042268972,"RBMS2","RNA binding motif single stranded interacting protein 2",TRUE
+"225776_at",0.497725944448536,0.0307717809515355,2.30705961727476,-3.634417755354,1.4607694939117,"RBMS2","RNA binding motif single stranded interacting protein 2",TRUE
+"235558_at",0.514859654632837,0.0354069008032824,2.24047870627272,-3.75211985974198,0.746908213305328,"RBMS2","RNA binding motif single stranded interacting protein 2",TRUE
+"34187_at",0.517859245504688,0.0369960349874954,2.21947688251654,-3.78881958918167,1.30638277382417,"RBMS2","RNA binding motif single stranded interacting protein 2",TRUE
+"205228_at",0.523369751179323,0.038835731145554,2.19616489522866,-3.82931016931911,1.48519392120325,"RBMS2","RNA binding motif single stranded interacting protein 2",TRUE
+"238447_at",0.713673813939397,0.188868315453699,1.35565128792207,-5.08213515535049,1.72139924695146,"RBMS3","RNA binding motif single stranded interacting protein 3",TRUE
+"1560322_at",0.783844746433788,0.306520763872357,1.04670453533395,-5.41970133427017,0.86279857224593,"RBMS3","RNA binding motif single stranded interacting protein 3",TRUE
+"237860_at",0.803583569469174,0.341905763345673,-0.971254739366992,-5.49037629347009,-0.925191096682817,"RBMS3","RNA binding motif single stranded interacting protein 3",TRUE
+"242137_at",0.835952408568777,0.416324341232777,0.828317566749041,-5.61091826532491,0.892916567619808,"RBMS3","RNA binding motif single stranded interacting protein 3",TRUE
+"241789_at",0.854040699678541,0.463246243326693,0.746444506108316,-5.6718857688844,0.918709329144131,"RBMS3","RNA binding motif single stranded interacting protein 3",TRUE
+"206767_at",0.859486825765374,0.47711381395709,0.723215025361319,-5.68809129896624,0.388851621663377,"RBMS3","RNA binding motif single stranded interacting protein 3",TRUE
+"235570_at",0.925091998149497,0.675871502191876,0.423697263751209,-5.8526224572868,0.326730147929087,"RBMS3","RNA binding motif single stranded interacting protein 3",TRUE
+"237329_at",0.855662813198157,0.468981389664475,0.736788450348637,-5.67868114241985,0.40840767668956,"RBMS3-AS3","RBMS3 antisense RNA 3",TRUE
+"204098_at",0.780429362666663,0.301923547550771,-1.05694847030386,-5.409738254014,-0.365722686276618,"RBMX2","RNA binding motif protein, X-linked 2",TRUE
+"204097_s_at",0.932269331146744,0.701455265563415,-0.388361209087591,-5.86648826787799,-0.12919590861774,"RBMX2","RNA binding motif protein, X-linked 2",TRUE
+"227748_at",0.808257777979515,0.350909292452934,0.952924488181466,-5.50681972661228,0.33344068318334,"RBMXL1","RNA binding motif protein, X-linked like 1",TRUE
+"207208_at",0.89316156038085,0.566960942348515,0.581216202329826,-5.77647356569784,0.358991673771679,"RBMXL2","RNA binding motif protein, X-linked like 2",TRUE
+"207207_at",0.934200936091995,0.708712802104623,-0.378430079136198,-5.87017119571664,-0.333145181020099,"RBMXL2","RNA binding motif protein, X-linked like 2",TRUE
+"208307_at",0.697699759202153,0.168362444216854,1.42405499631506,-4.9974560498579,0.784508465389775,"RBMY1J///RBMY1E///RBMY1D///RBMY1B///RBMY1F///RBMY1A1","RNA binding motif protein, Y-linked, family 1, member J///RNA binding motif protein, Y-linked, family 1, member E///RNA binding motif protein, Y-linked, family 1, member D///RNA binding motif protein, Y-linked, family 1, member B///RNA binding motif protein, Y-linked, family 1, member F///RNA binding motif protein, Y-linked, family 1, member A1",TRUE
+"1565320_at",0.775341201891078,0.291722993652074,-1.08008172243687,-5.38691954906405,-0.778732995892171,"RBMY3AP","RNA binding motif protein, Y-linked, family 3, member A pseudogene",TRUE
+"1565132_at",0.877510999184545,0.527689434470809,0.641640415214484,-5.74112357714697,0.228273381369609,"RBMY3AP","RNA binding motif protein, Y-linked, family 3, member A pseudogene",TRUE
+"203423_at",0.393258278493143,0.0134574529320653,2.68561638497222,-2.93009076551421,2.8989212995131,"RBP1","retinol binding protein 1",TRUE
+"239782_at",0.68033297785336,0.147801110806461,1.49972379892181,-4.89982337759526,0.977204347808613,"RBP1","retinol binding protein 1",TRUE
+"231734_at",0.935318317015903,0.712428510221853,0.373360571414171,-5.87201493260452,0.302266804712926,"RBP2","retinol binding protein 2",TRUE
+"210318_at",0.896229101808264,0.57966781814204,0.562133967004646,-5.7869351602135,0.367134996859777,"RBP3","retinol binding protein 3",TRUE
+"219140_s_at",0.75710709622615,0.252965793714064,1.1737305073539,-5.29007559203233,1.03946393753068,"RBP4","retinol binding protein 4",TRUE
+"222049_s_at",0.834265235157814,0.412298338152028,-0.835603967126041,-5.60520412697984,-0.328913849986367,"RBP4","retinol binding protein 4",TRUE
+"223820_at",0.863918945062466,0.490146773121219,0.701741184699076,-5.70263855495819,0.308887066957331,"RBP5","retinol binding protein 5",TRUE
+"238066_at",0.634232520114868,0.105413958788528,1.68812936847107,-4.63949691029555,2.60939545901328,"RBP7","retinol binding protein 7",TRUE
+"229540_at",0.886783047600321,0.550094848539883,0.606886953095997,-5.76186719404973,0.394641300184403,"RBPJ","recombination signal binding protein for immunoglobulin kappa J region",TRUE
+"211974_x_at",0.925248256808575,0.676298515502477,0.423103080207628,-5.85286542499726,0.143493613054993,"RBPJ","recombination signal binding protein for immunoglobulin kappa J region",TRUE
+"207785_s_at",0.94632739401154,0.757208774785156,-0.312998802775864,-5.89207908434001,-0.114666132936845,"RBPJ","recombination signal binding protein for immunoglobulin kappa J region",TRUE
+"221377_s_at",0.994683443051162,0.975260500862374,0.0313634493917466,-5.93920438468561,0.0135862382441125,"RBPJL","recombination signal binding protein for immunoglobulin kappa J region like",TRUE
+"1557223_at",0.693286330555422,0.162471297399733,1.44493481057209,-4.97092603134155,0.521570067072177,"RBPMS","RNA binding protein with multiple splicing",TRUE
+"207837_at",0.748184017928985,0.240570197050732,1.20591560758218,-5.25516409670168,1.2909297186662,"RBPMS","RNA binding protein with multiple splicing",TRUE
+"231961_at",0.898405288322584,0.587652196908712,-0.550251077112979,-5.79327865198499,-0.467975813642584,"RBPMS","RNA binding protein with multiple splicing",TRUE
+"209487_at",0.90327207267628,0.603271751364372,-0.527232627985529,-5.8051919198004,-0.464705973454233,"RBPMS","RNA binding protein with multiple splicing",TRUE
+"209488_s_at",0.942324052902057,0.74091389035529,-0.334814637887889,-5.88523030289574,-0.34499340121728,"RBPMS","RNA binding protein with multiple splicing",TRUE
+"207836_s_at",0.94713024133591,0.759971266860379,-0.309315946756503,-5.89319019547684,-0.233895476944493,"RBPMS","RNA binding protein with multiple splicing",TRUE
+"240929_at",0.886783047600321,0.550331978745595,-0.606523208543637,-5.76207841832223,-0.211006154136245,"RBPMS-AS1","RBPMS antisense RNA 1",TRUE
+"228802_at",0.968271298107834,0.851083526952458,-0.189942593869733,-5.92212638706154,-0.242186042308896,"RBPMS2","RNA binding protein with multiple splicing 2",TRUE
+"226581_at",0.702888118552354,0.174758347908018,-1.40203944146568,-5.02508571208001,-0.428894519570497,"RBSN","rabenosyn, RAB effector",TRUE
+"231765_at",0.914588178928864,0.640159467915044,0.473968781922759,-5.83085487840003,0.152089092652274,"RBSN","rabenosyn, RAB effector",TRUE
+"1569714_at",0.968397958125511,0.851464015381211,0.189451165713222,-5.92221704018873,0.106081430171621,"RBSN","rabenosyn, RAB effector",TRUE
+"218117_at",0.931370027472813,0.695625062770035,-0.39636804530986,-5.86345050674611,-0.120381631215484,"RBX1","ring-box 1",TRUE
+"228996_at",0.837609393049242,0.421904124475378,-0.818292152241463,-5.61870381203279,-0.367425472847103,"RC3H1","ring finger and CCCH-type domains 1",TRUE
+"215109_at",0.839519981963042,0.427524064929573,0.80827822529652,-5.62639170204323,0.353917628599351,"RC3H1","ring finger and CCCH-type domains 1",TRUE
+"225893_at",0.876632890672003,0.525390296096654,0.645251337416706,-5.73890459400984,0.188580636231812,"RC3H1","ring finger and CCCH-type domains 1",TRUE
+"230133_at",0.774230543658252,0.286409475033803,1.09236246233836,-5.37462656418111,0.288628866538756,"RC3H2","ring finger and CCCH-type domains 2",TRUE
+"230134_s_at",0.834265235157814,0.412358286934198,0.835495140320819,-5.60528981528256,0.263929980868294,"RC3H2","ring finger and CCCH-type domains 2",TRUE
+"225813_at",0.882420879090034,0.54005610344967,0.622362658643992,-5.75276743882648,0.192753998045449,"RC3H2","ring finger and CCCH-type domains 2",TRUE
+"220202_s_at",0.919695424525124,0.658673243374214,0.447760619522701,-5.84250138455675,0.12896907885133,"RC3H2","ring finger and CCCH-type domains 2",TRUE
+"238421_at",0.974627631389842,0.875836843403331,0.158065616148822,-5.92752165732547,0.0465509256702159,"RC3H2","ring finger and CCCH-type domains 2",TRUE
+"231716_at",0.985425981490741,0.929066637991007,0.0900371846579848,-5.93573577990363,0.0334123688856511,"RC3H2","ring finger and CCCH-type domains 2",TRUE
+"220201_at",0.987024385896683,0.940091420814206,0.0760123943453839,-5.93686967822668,0.0303072389825605,"RC3H2","ring finger and CCCH-type domains 2",TRUE
+"208370_s_at",0.948429371744093,0.765600417893323,-0.301824793609089,-5.8954100483617,-0.319999996479584,"RCAN1","regulator of calcineurin 1",TRUE
+"215253_s_at",0.976589025744684,0.88868858742406,-0.141583332638732,-5.92992460502012,-0.117845523381362,"RCAN1","regulator of calcineurin 1",TRUE
+"215254_at",0.997763494670794,0.989076975723134,0.0138457316929289,-5.93959010909074,0.0112972629371351,"RCAN1","regulator of calcineurin 1",TRUE
+"203498_at",0.990627530017502,0.952783852452724,0.0598853063984973,-5.93793690158319,0.0313389170257095,"RCAN2","regulator of calcineurin 2",TRUE
+"219864_s_at",0.678096733656268,0.145303137847638,1.50949014143421,-4.88692557957715,1.1411037840913,"RCAN3","RCAN family member 3",TRUE
+"226272_at",0.7717895132349,0.281578501563577,1.10367148772579,-5.36319685551729,0.776840759799756,"RCAN3","RCAN family member 3",TRUE
+"229064_s_at",0.858711967211834,0.474520711904,0.727528171456131,-5.68511910599725,0.668181751163342,"RCAN3","RCAN family member 3",TRUE
+"237417_at",0.667209925683767,0.13370538170351,1.55672491908992,-4.82360647605986,1.05927977849444,"RCBTB1","RCC1 and BTB domain containing protein 1",TRUE
+"1554934_at",0.731965025847759,0.215621436446454,1.2747009756691,-5.17782069306158,0.724519592493066,"RCBTB1","RCC1 and BTB domain containing protein 1",TRUE
+"218352_at",0.757270745916058,0.253069588527622,-1.17346603155921,-5.29035905687259,-0.459677129241763,"RCBTB1","RCC1 and BTB domain containing protein 1",TRUE
+"204759_at",0.854184492233394,0.464441923340151,0.744425549841932,-5.67331352887118,0.776036468289198,"RCBTB2","RCC1 and BTB domain containing protein 2",TRUE
+"1561585_at",0.961539013416204,0.825663738422642,0.222889173616907,-5.9155153138852,0.117639730512435,"RCBTB2","RCC1 and BTB domain containing protein 2",TRUE
+"206499_s_at",0.86333554038125,0.487642491648868,-0.705841487703096,-5.69989310156532,-0.251068841264305,"RCC1","regulator of chromosome condensation 1",TRUE
+"215747_s_at",0.96696492045873,0.845893868663988,-0.19665024562614,-5.92086564036807,-0.0778816170898846,"RCC1","regulator of chromosome condensation 1",TRUE
+"221247_s_at",0.612420348961838,0.084066577737018,-1.80884353162731,-4.46052198950475,-0.506589084045302,"RCC1L","RCC1 like",TRUE
+"1554410_a_at",0.745633950719346,0.237301183289572,-1.21461055332321,-5.24559184094363,-0.382183931977041,"RCC1L","RCC1 like",TRUE
+"1554409_at",0.816366892489054,0.367601438264763,0.919764823383338,-5.53583563834697,0.539207014447598,"RCC1L","RCC1 like",TRUE
+"238132_at",0.858641716553081,0.474447643324831,0.727649907521279,-5.68503497387941,0.587702272547998,"RCC1L","RCC1 like",TRUE
+"224578_at",0.99176128617116,0.962031121598055,0.0481461543584002,-5.93855450606588,0.0166843473637126,"RCC2","regulator of chromosome condensation 2",TRUE
+"226488_at",0.928596293858875,0.686168579030595,-0.409411562460591,-5.85837114398065,-0.144458699033239,"RCCD1","RCC1 domain containing 1",TRUE
+"231290_at",0.932830928398943,0.703636000427641,0.385372981294065,-5.86760633455523,0.182204972215412,"RCCD1","RCC1 domain containing 1",TRUE
+"205333_s_at",0.94895689004559,0.768101254997544,0.298502406625474,-5.89637730349483,0.128307242745526,"RCE1","Ras converting CAAX endopeptidase 1",TRUE
+"205332_at",0.983647093636644,0.920229516954995,-0.101292255189508,-5.93468738939169,-0.0534102057579249,"RCE1","Ras converting CAAX endopeptidase 1",TRUE
+"212743_at",0.547343369043481,0.0479106935080629,-2.09404229727337,-4.00353674959383,-1.09875102062481,"RCHY1","ring finger and CHY zinc finger domain containing 1",TRUE
+"212749_s_at",0.555180272174837,0.0514069542018173,-2.05930626477741,-4.06158882311528,-0.767594817470505,"RCHY1","ring finger and CHY zinc finger domain containing 1",TRUE
+"214281_s_at",0.648927539488968,0.119701544639408,-1.6185079891399,-4.73847697353848,-0.566659797413083,"RCHY1","ring finger and CHY zinc finger domain containing 1",TRUE
+"235300_x_at",0.774230543658252,0.290126799486496,-1.08375384733663,-5.38325675402668,-0.54832868655585,"RCHY1","ring finger and CHY zinc finger domain containing 1",TRUE
+"222666_s_at",0.823274744098629,0.390082405498291,-0.876650755949472,-5.57214315702438,-0.533993449512314,"RCL1","RNA terminal phosphate cyclase like 1",TRUE
+"233981_at",0.942502815705589,0.741792539657951,0.333634149231873,-5.8856125836506,0.231186617494428,"RCL1","RNA terminal phosphate cyclase like 1",TRUE
+"218544_s_at",0.952339611416198,0.781868827493746,-0.280272205410469,-5.90149570761829,-0.124073578263644,"RCL1","RNA terminal phosphate cyclase like 1",TRUE
+"201063_at",0.612420348961838,0.0842831880771632,1.80749225620158,-4.46257546763827,1.40900175771027,"RCN1","reticulocalbin 1",TRUE
+"201485_s_at",0.940567117317801,0.733975806827842,0.344153355760599,-5.88215905569879,0.130993615953601,"RCN2","reticulocalbin 2",TRUE
+"201486_at",0.96518312904143,0.837904293003228,0.206994990449877,-5.91883584427181,0.0679945048866291,"RCN2","reticulocalbin 2",TRUE
+"61734_at",0.0985170196189519,0.000436102597224332,4.12792570525272,0.0754640073384634,4.0159344578663,"RCN3","reticulocalbin 3",TRUE
+"219102_at",0.196858188611682,0.0021451565735527,3.47256855636861,-1.32885842120162,2.35295084883606,"RCN3","reticulocalbin 3",TRUE
+"212612_at",0.809930331505913,0.353688403598408,-0.947331084002932,-5.51178026918936,-0.316373075949773,"RCOR1","REST corepressor 1",TRUE
+"237041_x_at",0.947326616179611,0.7604853362632,0.308631090837385,-5.89339537850508,0.314817198600776,"RCOR1","REST corepressor 1",TRUE
+"236030_at",0.89967769475675,0.591187892488,0.545014599933124,-5.7960322826737,0.265601741658088,"RCOR2","REST corepressor 2",TRUE
+"222605_at",0.683019114815084,0.151969441755522,-1.48372277671755,-4.92080958678234,-0.750943507634505,"RCOR3","REST corepressor 3",TRUE
+"241433_at",0.796378050779806,0.328928179559827,-0.998266617512472,-5.465624656687,-0.499911301318001,"RCOR3","REST corepressor 3",TRUE
+"218344_s_at",0.801547748171611,0.3383703028979,-0.978542662056141,-5.48375910295859,-0.493795552135483,"RCOR3","REST corepressor 3",TRUE
+"239328_at",0.468735421183467,0.0250427340634105,2.40344022041674,-3.46053654033295,1.34705552111422,"RCSD1","RCSD domain containing 1",TRUE
+"225763_at",0.845487921422997,0.442633552204821,0.781753756062892,-5.64632495244606,0.774734777147312,"RCSD1","RCSD domain containing 1",TRUE
+"206203_at",0.308621629697291,0.00622834569332713,3.02239212381398,-2.26259647843181,1.29469935842209,"RCVRN","recoverin",TRUE
+"236563_at",0.980832655742,0.910220098244708,0.114056669802322,-5.93334929920342,0.0842942610299167,"RD3","retinal degeneration 3",TRUE
+"226021_at",0.774230543658252,0.286784311168008,1.09149077423125,-5.37550320521343,0.774608581943095,"RDH10","retinol dehydrogenase 10 (all-trans)",TRUE
+"1552378_s_at",0.799008022536007,0.333500313115834,0.988667662506225,-5.47449116745423,1.00183153442106,"RDH10","retinol dehydrogenase 10 (all-trans)",TRUE
+"227467_at",0.893395477698951,0.568129261346408,0.579452691281873,-5.77745457203789,0.419440329257094,"RDH10","retinol dehydrogenase 10 (all-trans)",TRUE
+"1552379_at",0.972771173584025,0.868137112827781,0.167961691734168,-5.9259522134557,0.194959664463044,"RDH10","retinol dehydrogenase 10 (all-trans)",TRUE
+"217776_at",0.346977602268172,0.00896715778701284,-2.86459305380847,-2.57940502458654,-1.15863542652941,"RDH11","retinol dehydrogenase 11 (all-trans/9-cis/11-cis)",TRUE
+"217775_s_at",0.517654151778308,0.0366947496285471,-2.22339471247425,-3.78198920627265,-0.944999202948557,"RDH11","retinol dehydrogenase 11 (all-trans/9-cis/11-cis)",TRUE
+"232359_at",0.536713776711002,0.0435064555717084,2.14119564324732,-3.92373878605998,0.733857802371426,"RDH11","retinol dehydrogenase 11 (all-trans/9-cis/11-cis)",TRUE
+"217042_at",0.932739823750021,0.70287142475993,-0.386420259641478,-5.86721545680474,-0.153260348839364,"RDH11","retinol dehydrogenase 11 (all-trans/9-cis/11-cis)",TRUE
+"242998_at",0.977369242833284,0.891534895023272,-0.137938550012026,-5.93042035638848,-0.1026863262193,"RDH12","retinol dehydrogenase 12 (all-trans/9-cis/11-cis)",TRUE
+"1559190_s_at",0.544172907409316,0.0464576430800445,-2.10915174305357,-3.97809022633215,-0.909516132123855,"RDH13","retinol dehydrogenase 13",TRUE
+"225467_s_at",0.677013732819214,0.144189595144392,-1.51388808349599,-4.88109562894299,-0.576778242777495,"RDH13","retinol dehydrogenase 13",TRUE
+"235249_at",0.739367922105944,0.227104480060985,-1.24232748125427,-5.21468181132348,-0.684844003096157,"RDH13","retinol dehydrogenase 13",TRUE
+"225449_at",0.809930331505913,0.353534404103776,-0.947640253150101,-5.51150677947255,-0.289789881574274,"RDH13","retinol dehydrogenase 13",TRUE
+"206753_at",0.839519981963042,0.428055464262532,-0.807335607177546,-5.62711079424281,-0.544604086831454,"RDH16","retinol dehydrogenase 16 (all-trans)",TRUE
+"236291_at",0.986342822130003,0.934119394708212,0.0836073746700574,-5.93627938884565,0.0419695884268796,"RDH5","retinol dehydrogenase 5",TRUE
+"220683_at",0.831487912516861,0.405967282507093,0.847153980565907,-5.59605060481988,0.265698561085025,"RDH8","retinol dehydrogenase 8 (all-trans)",TRUE
+"239169_at",0.980459547037842,0.908888263723189,-0.11575649572781,-5.93315915272455,-0.0615956685511749,"RDM1","RAD52 motif containing 1",TRUE
+"204969_s_at",0.592488489935347,0.0694998272937315,1.9075117923385,-4.30763394756636,1.49467011416471,"RDX","radixin",TRUE
+"212398_at",0.622917527985155,0.0938134777391633,1.75081229366883,-4.54770035981932,1.21005524007711,"RDX","radixin",TRUE
+"212397_at",0.638684632383754,0.10968904797592,1.66650319327939,-4.67058276724528,1.33394211385649,"RDX","radixin",TRUE
+"244739_at",0.881970070870254,0.539312398343031,-0.623515221689344,-5.75208089447464,-0.71289733233745,"RDX","radixin",TRUE
+"240689_at",0.955396260969248,0.795597022263468,0.262190239053559,-5.9062563039112,0.0715990430511821,"REC114","REC114 meiotic recombination protein",TRUE
+"218599_at",0.775341201891078,0.291814280084853,1.0798721503323,-5.38712825395293,0.364064444255225,"REC8","REC8 meiotic recombination protein",TRUE
+"229536_at",0.886023097762234,0.548427662478433,0.609446659617206,-5.7603773323733,0.331625558550737,"REC8","REC8 meiotic recombination protein",TRUE
+"205407_at",0.785175995766517,0.310597097925501,1.03771191419069,-5.42837547599439,1.5642759749303,"RECK","reversion inducing cysteine rich protein with kazal motifs",TRUE
+"1558115_at",0.799008022536007,0.333589307956758,0.988481726845865,-5.47466214645588,0.997869680780155,"RECK","reversion inducing cysteine rich protein with kazal motifs",TRUE
+"1558116_x_at",0.824027323790285,0.391430806303722,0.874117102961722,-5.57422657025032,1.07941492058481,"RECK","reversion inducing cysteine rich protein with kazal motifs",TRUE
+"216156_at",0.968980656821882,0.853327128223103,-0.18704550821788,-5.9226574316842,-0.127419817100784,"RECK","reversion inducing cysteine rich protein with kazal motifs",TRUE
+"216153_x_at",0.969882914559333,0.856206490505154,0.183329881224232,-5.92332661031372,0.0785765390341044,"RECK","reversion inducing cysteine rich protein with kazal motifs",TRUE
+"210568_s_at",0.61760967235709,0.08821430836358,1.78347560350274,-4.49888669686961,0.912303105740206,"RECQL","RecQ like helicase",TRUE
+"212918_at",0.618995519360933,0.0893708391373608,1.77658569065484,-4.50923834582253,0.90935453039282,"RECQL","RecQ like helicase",TRUE
+"212917_x_at",0.621053291599968,0.0910513951535305,1.76670942954577,-4.52402562191221,0.829785788716485,"RECQL","RecQ like helicase",TRUE
+"205091_x_at",0.62952950109137,0.10036858652516,1.71463059286514,-4.60099206361209,0.937233349600856,"RECQL","RecQ like helicase",TRUE
+"1553015_a_at",0.911274533678096,0.629273650372515,-0.489536331080048,-5.82363011050624,-0.142895368715816,"RECQL4","RecQ like helicase 4",TRUE
+"213520_at",0.940769530623189,0.734892851447945,0.342917233298371,-5.88257037953511,0.124839664007007,"RECQL4","RecQ like helicase 4",TRUE
+"34063_at",0.69450946988669,0.163963936667533,-1.43958760299643,-4.97775027511279,-0.506257949595812,"RECQL5","RecQ like helicase 5",TRUE
+"1561720_at",0.7468442753788,0.238812049089436,1.21058079005646,-5.25003561594864,0.984637191019795,"RECQL5","RecQ like helicase 5",TRUE
+"210309_at",0.784789297644843,0.309270635489031,1.04062896266933,-5.42556911820659,0.484326561712521,"RECQL5","RecQ like helicase 5",TRUE
+"211468_s_at",0.863982129426672,0.490475478361415,-0.701203885857345,-5.70299718583414,-0.492446037812027,"RECQL5","RecQ like helicase 5",TRUE
+"221686_s_at",0.976446519373981,0.88828387881888,-0.142101732542527,-5.92985304578837,-0.0578079007582613,"RECQL5","RecQ like helicase 5",TRUE
+"204365_s_at",0.704665987011002,0.176593684395604,-1.39584094292705,-5.03280084110208,-1.01946891671629,"REEP1","receptor accessory protein 1",TRUE
+"204364_s_at",0.793654340638017,0.325459354532867,-1.00561106214657,-5.45878812080982,-1.11283539426227,"REEP1","receptor accessory protein 1",TRUE
+"205331_s_at",0.897949253801113,0.586139056017574,0.552496840481438,-5.79208986955671,0.32589331198055,"REEP2","receptor accessory protein 2",TRUE
+"225785_at",0.896229101808264,0.580128460167227,0.561446196946551,-5.78730590062421,0.173088311573064,"REEP3","receptor accessory protein 3",TRUE
+"235016_at",0.914588178928864,0.64031223934284,0.473751159449773,-5.8309542565694,0.231498814262823,"REEP3","receptor accessory protein 3",TRUE
+"218777_at",0.773234064853267,0.284347103127528,-1.09717334082882,-5.36977714450967,-0.307449704778708,"REEP4","receptor accessory protein 4",TRUE
+"208873_s_at",0.198010528134268,0.00217657663298939,-3.46651368081328,-1.34164638858138,-1.65807724703529,"REEP5","receptor accessory protein 5",TRUE
+"208872_s_at",0.569028849013362,0.058823064556443,-1.99211320828161,-4.1720673557352,-0.846136103863365,"REEP5","receptor accessory protein 5",TRUE
+"226597_at",0.55937703282623,0.0536970041719598,-2.03768276212912,-4.09740645282441,-2.16253837413829,"REEP6","receptor accessory protein 6",TRUE
+"209752_at",0.966676135540784,0.845178988119041,-0.197574947986924,-5.92068841782668,-0.275327399727678,"REG1A","regenerating family member 1 alpha",TRUE
+"205886_at",0.937113154905832,0.719334049830693,-0.363965321914738,-5.87536702342839,-0.162651900554751,"REG1B","regenerating family member 1 beta",TRUE
+"207778_at",0.997171203405,0.985666889869676,0.0181687027474036,-5.93952270163174,0.0131321395957249,"REG1CP","regenerating family member 1 gamma, pseudogene",TRUE
+"205815_at",0.877948371309952,0.529662984693044,0.63854768089893,-5.74301460871146,0.253570475177231,"REG3A","regenerating family member 3 alpha",TRUE
+"234280_at",0.975449397348071,0.882747306757436,-0.149197714871515,-5.92884728820079,-0.116484641065921,"REG3A","regenerating family member 3 alpha",TRUE
+"231661_at",0.793170935258109,0.325000612027205,1.00658640854675,-5.45787680696699,0.319810868450836,"REG3G","regenerating family member 3 gamma",TRUE
+"238984_at",0.657015752622694,0.125590002470613,1.59183243500023,-4.77554956787103,1.2710127744579,"REG4","regenerating family member 4",TRUE
+"1554436_a_at",0.716472449896956,0.192195153845478,-1.34511504747872,-5.09486982501887,-0.592677573156828,"REG4","regenerating family member 4",TRUE
+"223447_at",0.991689960875868,0.961045722540314,0.0493967314925575,-5.9384950985295,0.0270175031277615,"REG4","regenerating family member 4",TRUE
+"239486_at",0.725583196024696,0.204650150549997,1.30689616419063,-5.14036151096479,0.724747797773738,"REL","REL proto-oncogene, NF-kB subunit",TRUE
+"206035_at",0.728385463227073,0.20908605422322,1.29372191826503,-5.15578573636693,0.743999241105665,"REL","REL proto-oncogene, NF-kB subunit",TRUE
+"206036_s_at",0.766825795427257,0.267978792377295,1.13628422459078,-5.32965213761396,0.75701023452651,"REL","REL proto-oncogene, NF-kB subunit",TRUE
+"235242_at",0.769847953580141,0.278305001847182,1.11141473894068,-5.35531067051292,0.707130008078376,"REL","REL proto-oncogene, NF-kB subunit",TRUE
+"228812_at",0.792716268502624,0.324445549537162,1.00776782483608,-5.45677187966488,0.587920675393946,"REL","REL proto-oncogene, NF-kB subunit",TRUE
+"209878_s_at",0.940227139261806,0.732781169539703,0.345764477564355,-5.88162075326046,0.1251317325739,"RELA","RELA proto-oncogene, NF-kB subunit",TRUE
+"201783_s_at",0.998347572104896,0.99302419170558,-0.00884217206957631,-5.93964540027369,-0.00258105310134304,"RELA","RELA proto-oncogene, NF-kB subunit",TRUE
+"205205_at",0.538307479093131,0.0438522453018894,2.13734147149062,-3.93030348124461,1.4922569374433,"RELB","RELB proto-oncogene, NF-kB subunit",TRUE
+"226430_at",0.765228531154075,0.26526822554412,-1.14292840408767,-5.3227123281149,-0.381662155878328,"RELL1","RELT like 1",TRUE
+"1554714_at",0.840041055449124,0.429028820395174,-0.805610913702489,-5.62842446630613,-0.343788259404629,"RELL1","RELT like 1",TRUE
+"1564031_a_at",0.822173415758858,0.386466503752374,-0.883473293931038,-5.56650519304899,-0.32110712718632,"RELL2","RELT like 2",TRUE
+"205923_at",0.937623890519979,0.723942572074477,0.357713823727126,-5.87755073506306,0.311811803772898,"RELN","reelin",TRUE
+"227060_at",0.744307803443383,0.235065640601886,1.22060886499662,-5.23895359278574,0.753564984318597,"RELT","RELT tumor necrosis factor receptor",TRUE
+"210300_at",0.921312278448293,0.664764333577699,0.439208113794695,-5.84616143153921,0.32296633040916,"REM1","RRAD and GEM like GTPase 1",TRUE
+"235699_at",0.993354935415366,0.968764834906889,-0.039602348839093,-5.93891962609086,-0.0306189668673218,"REM2","RRAD and GEM like GTPase 2",TRUE
+"206367_at",0.70916118893503,0.181988854905302,1.37791186320605,-5.05495739759011,0.855080231021174,"REN","renin",TRUE
+"206617_s_at",0.993844815642169,0.970795977485164,0.0370258367328748,-5.93901578183283,0.0227800653668062,"RENBP","renin binding protein",TRUE
+"219041_s_at",0.0681210092794308,0.000174364322128083,-4.50193921249768,0.883281038908763,-1.84148917815871,"REPIN1","replication initiator 1",TRUE
+"222501_s_at",0.261279468198531,0.00389470080625154,-3.22244882326186,-1.85238341791785,-1.54058601694439,"REPIN1","replication initiator 1",TRUE
+"228815_s_at",0.904432955312383,0.608264998995529,0.519935095782658,-5.8088653509744,0.431030313169607,"REPIN1","replication initiator 1",TRUE
+"224366_s_at",0.673366993714442,0.139555504716301,1.53249506693356,-4.85628052825644,0.428724948931121,"REPS1","RALBP1 associated Eps domain containing 1",TRUE
+"215201_at",0.678096733656268,0.14530555704649,1.50948061687821,-4.88693819069951,1.31424946450521,"REPS1","RALBP1 associated Eps domain containing 1",TRUE
+"215922_at",0.96287357728432,0.831188075201092,0.215708881180177,-5.91704565467649,0.188864310199737,"REPS1","RALBP1 associated Eps domain containing 1",TRUE
+"242571_at",0.724067243569133,0.201229724292525,-1.31720687892858,-5.12819763296948,-1.67859085831212,"REPS2","RALBP1 associated Eps domain containing 2",TRUE
+"227425_at",0.903021267024792,0.602954212941283,-0.527697681501408,-5.80495613152415,-0.386747667474788,"REPS2","RALBP1 associated Eps domain containing 2",TRUE
+"205645_at",0.946727564264032,0.758628770837417,-0.311105166140051,-5.8926520184598,-0.244057135862921,"REPS2","RALBP1 associated Eps domain containing 2",TRUE
+"202296_s_at",0.87405589044596,0.519893399418255,0.653919749174155,-5.73352888024934,0.198983588175206,"RER1","retention in endoplasmic reticulum sorting receptor 1",TRUE
+"213296_at",0.877488742289724,0.527571521572089,0.641825394768732,-5.74101019433071,0.215140857157957,"RER1","retention in endoplasmic reticulum sorting receptor 1",TRUE
+"202297_s_at",0.91876780831279,0.654729566154834,0.453316047412196,-5.84008684929662,0.183283313235551,"RER1","retention in endoplasmic reticulum sorting receptor 1",TRUE
+"200938_s_at",0.707593266152278,0.178993607582635,1.38781259306624,-5.04275152355503,1.11387500145975,"RERE","arginine-glutamic acid dipeptide repeats",TRUE
+"200939_s_at",0.746535697909741,0.238199419357235,-1.21221246349381,-5.24823784871792,-0.770149481484792,"RERE","arginine-glutamic acid dipeptide repeats",TRUE
+"221643_s_at",0.780429362666663,0.301950853501593,-1.05688729871795,-5.40979800699079,-0.53760424316437,"RERE","arginine-glutamic acid dipeptide repeats",TRUE
+"200940_s_at",0.915353407558177,0.64275628666862,-0.470272766446697,-5.83253661573409,-0.179426471171446,"RERE","arginine-glutamic acid dipeptide repeats",TRUE
+"1557349_at",0.984515877561407,0.924415845753644,-0.0959589134209847,-5.93519954335419,-0.0617751114739775,"RERE","arginine-glutamic acid dipeptide repeats",TRUE
+"227758_at",0.565043084457947,0.0561551282932519,-2.01536898689448,-4.13410565508727,-2.62823978550287,"RERG","RAS like estrogen regulated growth inhibitor",TRUE
+"244745_at",0.638134354959023,0.109403361887174,-1.66792594697183,-4.66854702000988,-2.45415634925875,"RERG","RAS like estrogen regulated growth inhibitor",TRUE
+"220276_at",0.980257327353916,0.907448456638155,-0.117594520708609,-5.93295038590851,-0.10083187448125,"RERGL","RERG like",TRUE
+"212920_at",0.506052373093096,0.0331078957543834,-2.27243630287586,-3.69587908189311,-0.617353050463073,"REST","RE1 silencing transcription factor",TRUE
+"204535_s_at",0.866077812635028,0.49683640774207,-0.690846733169104,-5.70985904966933,-0.423920816842855,"REST","RE1 silencing transcription factor",TRUE
+"204536_s_at",0.928295253101366,0.685088141274101,0.410906398583764,-5.85777869349484,0.253952730029494,"REST","RE1 silencing transcription factor",TRUE
+"215771_x_at",0.656455052847087,0.124567373997047,-1.59638913232667,-4.76925075947791,-1.32533967456915,"RET","ret proto-oncogene",TRUE
+"205879_x_at",0.694505490882266,0.163772342701658,-1.44027176697052,-4.97687827911133,-1.23870141726626,"RET","ret proto-oncogene",TRUE
+"211421_s_at",0.726432421917557,0.205347457041709,-1.30481063845397,-5.14281203820751,-2.54833912819657,"RET","ret proto-oncogene",TRUE
+"220570_at",0.71611852101483,0.191788480093629,1.34639526779529,-5.09332692138827,0.991661111173082,"RETN","resistin",TRUE
+"223969_s_at",0.871744769522775,0.51431522249914,-0.662768150143342,-5.7279705754123,-0.435005750352958,"RETNLB","resistin like beta",TRUE
+"223970_at",0.878788356961452,0.532191335845462,0.634594655448527,-5.74541886890648,0.273113481645757,"RETNLB","resistin like beta",TRUE
+"218124_at",0.731054546207485,0.214130435921193,1.27900089194182,-5.17286374510294,0.428376246503962,"RETSAT","retinol saturase",TRUE
+"243592_at",0.745001525353357,0.236747631901309,-1.21609182723338,-5.243955167951,-0.883491970729087,"REV1","REV1, DNA directed polymerase",TRUE
+"218428_s_at",0.767727587789514,0.270169852040504,-1.13094945322442,-5.33519844261542,-0.360456324835335,"REV1","REV1, DNA directed polymerase",TRUE
+"222628_s_at",0.888830748858811,0.5559903779008,0.597867814069929,-5.76706848180941,0.183917301242385,"REV1","REV1, DNA directed polymerase",TRUE
+"222629_at",0.921312278448293,0.664878271257893,-0.439048452481349,-5.84622909999632,-0.163027058519554,"REV1","REV1, DNA directed polymerase",TRUE
+"208070_s_at",0.824399995824329,0.391807255651568,-0.873410764200891,-5.57480639179569,-0.398642933485672,"REV3L","REV3 like, DNA directed polymerase zeta catalytic subunit",TRUE
+"238736_at",0.988713664405312,0.945538537993663,0.0690889763918598,-5.93735885620918,0.045774512210361,"REV3L","REV3 like, DNA directed polymerase zeta catalytic subunit",TRUE
+"244281_at",0.771855357662161,0.282008855357171,1.10265838096179,-5.36422504119075,0.875284803977329,"REXO1","RNA exonuclease 1 homolog",TRUE
+"233939_at",0.86481525165637,0.492552241558323,0.697813996268238,-5.70525379464357,0.444475704888437,"REXO1","RNA exonuclease 1 homolog",TRUE
+"1553009_s_at",0.888756025960104,0.555572079657328,-0.598506083351679,-5.76670286836988,-0.218380287341166,"REXO1L1P","REX1, RNA exonuclease 1 homolog-like 1, pseudogene",TRUE
+"239616_at",0.532405994061663,0.0419000763766889,2.15947118282307,-3.89250961802627,0.649232807399208,"REXO2","RNA exonuclease 2",TRUE
+"223989_s_at",0.64513208805899,0.116046077235924,1.63562525045546,-4.71443748042443,0.807873479113807,"REXO2","RNA exonuclease 2",TRUE
+"233613_x_at",0.689168483917391,0.158271742170131,1.46019485240526,-4.9513375690076,0.786476602771899,"REXO2","RNA exonuclease 2",TRUE
+"218194_at",0.728385463227073,0.209171923086316,1.2934690417579,-5.15608050351444,0.694400217405629,"REXO2","RNA exonuclease 2",TRUE
+"218767_at",0.666643938027574,0.133547700322298,-1.55739001558918,-4.82270388415046,-0.439775518353041,"REXO4","REX4 homolog, 3'-5' exonuclease",TRUE
+"208021_s_at",0.647754107214051,0.119192197748713,1.62086658636566,-4.73517614357241,0.507573111146794,"RFC1","replication factor C subunit 1",TRUE
+"209085_x_at",0.676020192063893,0.142453152475271,1.52080202549778,-4.87190308109684,0.443273026563665,"RFC1","replication factor C subunit 1",TRUE
+"208133_at",0.897949253801113,0.586764187615587,-0.551568689206809,-5.79258175135489,-0.29029665740421,"RFC1","replication factor C subunit 1",TRUE
+"203696_s_at",0.571288960886906,0.0591667109870492,-1.98918612842411,-4.17682445123817,-0.646943083353415,"RFC2","replication factor C subunit 2",TRUE
+"1053_at",0.704396794850573,0.176282786354648,-1.39688731863668,-5.03150042218847,-0.388521887239845,"RFC2","replication factor C subunit 2",TRUE
+"231119_at",0.864726282448413,0.492154594553813,0.698462437748551,-5.70482294176278,0.54939978027976,"RFC3","replication factor C subunit 3",TRUE
+"204128_s_at",0.96350209729653,0.833491530710832,0.212718395075586,-5.91766830540446,0.0774902482536195,"RFC3","replication factor C subunit 3",TRUE
+"204127_at",0.975552150564853,0.883608468234224,0.14809349602627,-5.92900700852167,0.0445659753931196,"RFC3","replication factor C subunit 3",TRUE
+"204023_at",0.884815577925557,0.544881650011312,0.614904722578426,-5.75718030208313,0.236796067240242,"RFC4","replication factor C subunit 4",TRUE
+"203209_at",0.729041056651108,0.210502758717894,-1.28956007709574,-5.16063078500499,-0.46314344906814,"RFC5","replication factor C subunit 5",TRUE
+"203210_s_at",0.821962235882611,0.385172434762778,-0.885925070169781,-5.56446921131943,-0.302560416769142,"RFC5","replication factor C subunit 5",TRUE
+"213734_at",0.877333806479767,0.527031020722295,0.642673611015105,-5.74048987984522,0.334314429318345,"RFC5","replication factor C subunit 5",TRUE
+"236305_at",0.627021415091472,0.0975681659767906,1.72983326350224,-4.57870096552302,0.65884234780575,"RFESD","Rieske Fe-S domain containing",TRUE
+"239142_at",0.849189309967511,0.450027622429056,0.768975732584953,-5.65570397241172,0.259577154076835,"RFESD","Rieske Fe-S domain containing",TRUE
+"242155_x_at",0.429284714913652,0.0189117340207141,2.53244793806618,-3.22175146251476,0.622723579604012,"RFFL","ring finger and FYVE-like domain containing E3 ubiquitin protein ligase",TRUE
+"237919_at",0.751464513744428,0.244440836150228,1.19573470875312,-5.26629632616353,0.482121590352553,"RFFL","ring finger and FYVE-like domain containing E3 ubiquitin protein ligase",TRUE
+"1566171_at",0.7717895132349,0.281708707522194,-1.10336484820288,-5.36350814753911,-0.480410141735079,"RFFL","ring finger and FYVE-like domain containing E3 ubiquitin protein ligase",TRUE
+"203224_at",0.637176949657524,0.108087022702968,-1.67452232714682,-4.65909135431555,-0.797029011652011,"RFK","riboflavin kinase",TRUE
+"203225_s_at",0.77547560202111,0.292472014508346,-1.07836353721848,-5.38862955715344,-0.459218122483945,"RFK","riboflavin kinase",TRUE
+"212968_at",0.739367922105944,0.227285114978438,-1.24182832801746,-5.21524378398684,-0.465841373827375,"RFNG","RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase",TRUE
+"207934_at",0.986889306520757,0.939394116282178,-0.0768989529599969,-5.93680366817466,-0.055231449663335,"RFPL1","ret finger protein like 1",TRUE
+"214120_at",0.682744111897512,0.150710595659601,-1.48851702972241,-4.91454066051262,-1.40257815123466,"RFPL1S","RFPL1 antisense RNA 1",TRUE
+"214408_s_at",0.991957147109766,0.962928680070431,-0.0470071248798956,-5.93860728937252,-0.0221474626770615,"RFPL1S///RFPL3S","RFPL1 antisense RNA 1///RFPL3 antisense",TRUE
+"207227_x_at",0.971242929121865,0.863580167036407,-0.17382653754233,-5.924977251155,-0.0871687502331335,"RFPL2","ret finger protein like 2",TRUE
+"207936_x_at",0.929088231432081,0.687712383407075,-0.40727728147143,-5.85921334416561,-0.120120532515243,"RFPL3","ret finger protein like 3",TRUE
+"214409_at",0.54295328972902,0.0458477392903526,-2.11562070331758,-3.96715980812673,-1.77800162369447,"RFPL3S","RFPL3 antisense",TRUE
+"226060_at",0.91876780831279,0.654462493590655,-0.453692792828772,-5.83992204888183,-0.143344258402323,"RFT1","RFT1 homolog",TRUE
+"1558289_at",0.968451827985008,0.851808068557209,-0.189006837406287,-5.92229880340227,-0.113033899169399,"RFT1","RFT1 homolog",TRUE
+"1569787_at",0.448873991611994,0.0214082727588236,-2.47579560743237,-3.32742773675087,-1.36520172532283,"RFTN1","raftlin, lipid raft linker 1",TRUE
+"212646_at",0.519634645385185,0.0374365042189711,2.21380105378635,-3.79870191628649,2.46637819623923,"RFTN1","raftlin, lipid raft linker 1",TRUE
+"241698_at",0.76858139690485,0.271767096550412,1.12708045003045,-5.33920643835174,1.21709582757077,"RFTN2","raftlin family member 2",TRUE
+"238955_at",0.959451355429682,0.816628833068412,-0.234658414014211,-5.91289909007339,-0.0964094652199332,"RFTN2","raftlin family member 2",TRUE
+"1552617_a_at",0.846248434359032,0.444252330520145,-0.778945222054707,-5.64839890617009,-0.245916807507193,"RFWD2","ring finger and WD repeat domain 2",TRUE
+"234950_s_at",0.91671872326659,0.647704041929185,-0.463249000431783,-5.83569700037905,-0.146720036729711,"RFWD2","ring finger and WD repeat domain 2",TRUE
+"218564_at",0.999487122561121,0.998317169642166,0.00213304094801722,-5.9396812646785,0.000876945820859731,"RFWD3","ring finger and WD repeat domain 3",TRUE
+"206321_at",0.79782885150643,0.331642241497471,0.992557548901223,-5.47090747917591,0.551488982624989,"RFX1","regulatory factor X1",TRUE
+"226786_at",0.921980251030053,0.667162118548681,0.435850526318793,-5.84757937434075,0.130974282478402,"RFX1","regulatory factor X1",TRUE
+"226872_at",0.891390319214715,0.56085447409795,0.590464097876565,-5.77128192746262,0.42443247441498,"RFX2","regulatory factor X2",TRUE
+"208031_s_at",0.929126743655924,0.688452275978024,-0.406255076100269,-5.85961517833305,-0.228436523863362,"RFX2","regulatory factor X2",TRUE
+"242966_x_at",0.993474831312851,0.969513017345586,-0.0386532455483752,-5.93895579888679,-0.0127118961371329,"RFX2","regulatory factor X2",TRUE
+"243868_at",0.778974960380281,0.300106603849113,1.06102771873299,-5.40574660662456,0.916809520092698,"RFX3","regulatory factor X3",TRUE
+"207234_at",0.854400503339099,0.465844019018954,0.742061985974915,-5.67498033015505,0.282801690849718,"RFX3","regulatory factor X3",TRUE
+"238810_at",0.898829793951155,0.588797218109823,0.548553567590477,-5.79417409861856,0.507844940582047,"RFX3","regulatory factor X3",TRUE
+"230403_at",0.955816406528307,0.798844990445595,0.257925468120643,-5.90733318362018,0.257705916646676,"RFX3","regulatory factor X3",TRUE
+"1552809_at",0.717937808890208,0.193665802934015,1.34050309011886,-5.10041788991655,0.803113974012414,"RFX4","regulatory factor X4",TRUE
+"207672_at",0.854122897879129,0.463639935732138,0.74577939763155,-5.67235652324166,0.481083100679216,"RFX4","regulatory factor X4",TRUE
+"223673_at",0.913627134030439,0.637650474076942,0.477546171154839,-5.82921484905461,0.380230947296368,"RFX4","regulatory factor X4",TRUE
+"202964_s_at",0.773657212801073,0.285180676352248,-1.09522584484394,-5.37174252724495,-0.504251236233692,"RFX5","regulatory factor X5",TRUE
+"202963_at",0.946416600885596,0.757856592053683,-0.3121347612028,-5.89234093390842,-0.121906644726215,"RFX5","regulatory factor X5",TRUE
+"1552673_at",0.88113080359582,0.537489412466402,0.626344015732194,-5.75039068832326,0.477291158332376,"RFX6","regulatory factor X6",TRUE
+"222630_at",0.518537987260825,0.0371407212236192,-2.2176057285815,-3.79207919963626,-1.10839687327965,"RFX7","regulatory factor X7",TRUE
+"218430_s_at",0.660460734341314,0.128599889384322,-1.578597650675,-4.79376456557479,-0.684511469920063,"RFX7","regulatory factor X7",TRUE
+"202758_s_at",0.768852835478002,0.273272992672966,-1.1234479312237,-5.34295840359789,-0.480502800561865,"RFXANK","regulatory factor X associated ankyrin containing protein",TRUE
+"208492_at",0.956734254923335,0.803523204416936,-0.25179125909399,-5.90885133387282,-0.143898457803136,"RFXAP","regulatory factor X associated protein",TRUE
+"229431_at",0.966769992359004,0.845435274708021,0.197243419490255,-5.92075205170452,0.0824173124072463,"RFXAP","regulatory factor X associated protein",TRUE
+"232785_at",0.773234064853267,0.284283337166116,-1.09732248858654,-5.36962649884489,-0.377745103508468,"RGAG1","retrotransposon gag domain containing 1",TRUE
+"227823_at",0.897195709148439,0.583246951810937,-0.556797243069584,-5.78980035677412,-0.456338048245436,"RGAG4","retrotransposon gag domain containing 4",TRUE
+"218723_s_at",0.508488499910913,0.03366768700106,2.26447246237257,-3.70993859326147,2.52877331435099,"RGCC","regulator of cell cycle",TRUE
+"239827_at",0.624331975868069,0.0957879801429312,1.73969218212685,-4.5641669886113,1.32662706195992,"RGCC","regulator of cell cycle",TRUE
+"228193_s_at",0.871451481476429,0.512877288906238,0.665057696618337,-5.72652068781252,0.324919119403833,"RGCC","regulator of cell cycle",TRUE
+"209568_s_at",0.997608949249317,0.987911847370625,-0.0153227320281439,-5.93956912573508,-0.00877162506496276,"RGL1","ral guanine nucleotide dissociation stimulator like 1",TRUE
+"209110_s_at",0.791045390251277,0.321138899167561,-1.01483515774536,-5.45013759944731,-0.465040497492566,"RGL2","ral guanine nucleotide dissociation stimulator like 2",TRUE
+"1556355_x_at",0.6708432030569,0.136644502069501,1.54444483111062,-4.84021689727938,1.32004253319501,"RGL3","ral guanine nucleotide dissociation stimulator like 3",TRUE
+"228877_at",0.695744345349551,0.165558450642022,1.43391856565622,-4.98496268231192,1.21882889451628,"RGL3","ral guanine nucleotide dissociation stimulator like 3",TRUE
+"1556354_s_at",0.819018525257656,0.373119763906685,0.909024231869186,-5.54503118334423,0.952651969741142,"RGL3","ral guanine nucleotide dissociation stimulator like 3",TRUE
+"215054_at",0.943988850936011,0.749045378935446,0.323908035131422,-5.888711360522,0.166920319567383,"RGL3///EPOR","ral guanine nucleotide dissociation stimulator like 3///erythropoietin receptor",TRUE
+"235816_s_at",0.719333457476224,0.19525718077543,1.33554338166767,-5.10636644354387,0.614453205747997,"RGL4","ral guanine nucleotide dissociation stimulator like 4",TRUE
+"223468_s_at",0.927013423736714,0.681217107249999,0.416270011600047,-5.85563544273106,0.328900044375724,"RGMA","repulsive guidance molecule family member a",TRUE
+"234406_at",0.940668681806864,0.734310248327682,0.343702484967039,-5.88230925397171,0.228492865012131,"RGMA","repulsive guidance molecule family member a",TRUE
+"227340_s_at",0.740610299769501,0.230413722496757,-1.23323049742154,-5.22489313758337,-0.75933216435493,"RGMB","repulsive guidance molecule family member b",TRUE
+"242450_at",0.774230543658252,0.287033782012844,-1.09091108094416,-5.37608584721787,-0.865540915005064,"RGMB","repulsive guidance molecule family member b",TRUE
+"226989_at",0.838610044014507,0.423760737010202,-0.81497476600417,-5.62126046872436,-0.372529025378132,"RGMB","repulsive guidance molecule family member b",TRUE
+"227339_at",0.903919439852106,0.60571644521832,0.52365615964473,-5.80699847237406,0.630040823828328,"RGMB","repulsive guidance molecule family member b",TRUE
+"1558899_s_at",0.828239270394399,0.398054747291333,-0.861752063942195,-5.58431386827726,-0.645691940519408,"RGMB-AS1","RGMB antisense RNA 1",TRUE
+"210751_s_at",0.855405088766616,0.468219493232528,0.73806717906456,-5.67778606762502,0.514344620823749,"RGN","regucalcin",TRUE
+"203169_at",0.861665593344139,0.48370142690951,-0.712318953023928,-5.69552491305015,-0.233144856417601,"RGP1","RGP1 homolog, RAB6A GEF complex partner 1",TRUE
+"235597_s_at",0.76159330462167,0.260759518290218,-1.1540918523396,-5.31097200382795,-0.893585719251767,"RGPD2///RGPD1","RANBP2-like and GRIP domain containing 2///RANBP2-like and GRIP domain containing 1",TRUE
+"242712_x_at",0.923392984964514,0.671251331909916,0.430136152515434,-5.84996804328568,0.148179294118863,"RGPD2///RGPD6///RGPD8///RGPD3///RGPD1///RGPD4///RGPD5///RANBP2","RANBP2-like and GRIP domain containing 2///RANBP2-like and GRIP domain containing 6///RANBP2-like and GRIP domain containing 8///RANBP2-like and GRIP domain containing 3///RANBP2-like and GRIP domain containing 1///RANBP2-like and GRIP domain containing 4///RANBP2-like and GRIP domain containing 5///RAN binding protein 2",TRUE
+"1558623_at",0.0723378272955723,0.00022903291925418,4.39067589395162,0.64316950152313,2.61809615513016,"RGPD4-AS1","RGPD4 antisense RNA 1 (head to head)",TRUE
+"211324_s_at",0.875938621758472,0.524401833963631,-0.646806425274867,-5.7379452767609,-0.439051060017408,"RGPD6///RGPD8///RGPD3///RGPD4///RGPD5","RANBP2-like and GRIP domain containing 6///RANBP2-like and GRIP domain containing 8///RANBP2-like and GRIP domain containing 3///RANBP2-like and GRIP domain containing 4///RANBP2-like and GRIP domain containing 5",TRUE
+"210676_x_at",0.944785393058556,0.751511454585241,0.320608303513778,-5.88974205195756,0.132936114048526,"RGPD6///RGPD8///RGPD3///RGPD4///RGPD5","RANBP2-like and GRIP domain containing 6///RANBP2-like and GRIP domain containing 8///RANBP2-like and GRIP domain containing 3///RANBP2-like and GRIP domain containing 4///RANBP2-like and GRIP domain containing 5",TRUE
+"212842_x_at",0.94838899137468,0.764730232514596,0.302981655331627,-5.89507075717406,0.128364649505846,"RGPD6///RGPD8///RGPD3///RGPD4///RGPD5","RANBP2-like and GRIP domain containing 6///RANBP2-like and GRIP domain containing 8///RANBP2-like and GRIP domain containing 3///RANBP2-like and GRIP domain containing 4///RANBP2-like and GRIP domain containing 5",TRUE
+"1555219_at",0.687341045901496,0.155985874669333,1.46863919073127,-4.94042627794953,0.948532996420738,"RGR","retinal G protein coupled receptor",TRUE
+"1559714_at",0.869056640409671,0.505497552530614,0.676864869246929,-5.71896762396222,0.23412177108444,"RGR","retinal G protein coupled receptor",TRUE
+"207070_at",0.953962927183502,0.787597376004815,0.272715645566179,-5.90352351636165,0.267526357848004,"RGR","retinal G protein coupled receptor",TRUE
+"202989_at",0.846961593117459,0.445640440984052,0.776541858812608,-5.6501680735497,0.77831769231282,"RGS1","regulator of G-protein signaling 1",TRUE
+"216834_at",0.94943075115007,0.771659826659272,0.293780704435811,-5.89773368138734,0.259113354624504,"RGS1","regulator of G-protein signaling 1",TRUE
+"202988_s_at",0.957932374330736,0.810684896544545,0.242419646714385,-5.91110056935687,0.190350507631554,"RGS1","regulator of G-protein signaling 1",TRUE
+"204319_s_at",0.517367684249416,0.0365824136681892,2.22486299197119,-3.77942751469717,1.1937060124024,"RGS10","regulator of G-protein signaling 10",TRUE
+"204316_at",0.870947480802804,0.510897019789744,0.668216636847622,-5.72451238045142,0.300492925032952,"RGS10","regulator of G-protein signaling 10",TRUE
+"214000_s_at",0.897949253801113,0.586222624341713,0.55237273573311,-5.79215568644979,0.431079984432293,"RGS10","regulator of G-protein signaling 10",TRUE
+"211872_s_at",0.854400503339099,0.465852141039993,-0.742048306707934,-5.67498996224111,-0.354508168305204,"RGS11","regulator of G-protein signaling 11",TRUE
+"1554643_at",0.859465912277024,0.476674539355216,-0.72394470959519,-5.68758965340423,-0.736555316764354,"RGS11","regulator of G-protein signaling 11",TRUE
+"206107_at",0.896159990898752,0.579197868170178,-0.56283591693927,-5.78655632224775,-0.590634184229042,"RGS11","regulator of G-protein signaling 11",TRUE
+"214362_at",0.552420073963858,0.0502397527948807,2.07066077592164,-4.04268208091091,1.32361835305005,"RGS12","regulator of G-protein signaling 12",TRUE
+"209639_s_at",0.749197955891564,0.242319463227918,1.20129939902978,-5.26022181878138,0.548337129439408,"RGS12","regulator of G-protein signaling 12",TRUE
+"205823_at",0.751737092364469,0.244982421816192,-1.1943198573324,-5.26783688927652,-0.381543880725362,"RGS12","regulator of G-protein signaling 12",TRUE
+"1555022_at",0.770807031642694,0.279352090001656,-1.10893075650754,-5.35784583572331,-0.738948123561224,"RGS12","regulator of G-protein signaling 12",TRUE
+"1555032_at",0.855405088766616,0.468095980343102,0.738274592852895,-5.67764074490946,0.415573329834678,"RGS12","regulator of G-protein signaling 12",TRUE
+"1555033_a_at",0.874474734833648,0.520738334584366,-0.652584051084798,-5.7343617007094,-0.291714469774929,"RGS12","regulator of G-protein signaling 12",TRUE
+"209637_s_at",0.913572663544659,0.637343109036503,0.477984854372653,-5.82901290736444,0.130804351831127,"RGS12","regulator of G-protein signaling 12",TRUE
+"242079_at",0.924696623416105,0.674332534112292,0.425840007203124,-5.85174348456831,0.14355363713736,"RGS12","regulator of G-protein signaling 12",TRUE
+"214361_s_at",0.989454234821344,0.947849199872021,-0.0661531341996654,-5.93755220174578,-0.0374619927598578,"RGS12","regulator of G-protein signaling 12",TRUE
+"209638_x_at",0.99783553534859,0.989832405036948,0.0128881123479025,-5.93960257821152,0.00940085585909411,"RGS12","regulator of G-protein signaling 12",TRUE
+"1568751_at",0.68033297785336,0.147738697564435,1.49996616749149,-4.8995041083706,1.68599281204,"RGS13","regulator of G-protein signaling 13",TRUE
+"210258_at",0.762857166457304,0.26261768372004,1.14947396063485,-5.31584069819537,1.37667849093273,"RGS13","regulator of G-protein signaling 13",TRUE
+"1568752_s_at",0.936992192746977,0.718586882761912,-0.364980247170943,-5.87500897520435,-0.383852920550662,"RGS13","regulator of G-protein signaling 13",TRUE
+"204280_at",0.832758870942732,0.409617021802564,-0.840481740952407,-5.60135274680989,-0.389849460685538,"RGS14","regulator of G-protein signaling 14",TRUE
+"38290_at",0.849935057946582,0.452470160173176,-0.764782701168338,-5.65874983799991,-0.344367943007149,"RGS14","regulator of G-protein signaling 14",TRUE
+"211021_s_at",0.97304633500821,0.869336588282678,-0.166418962530302,-5.92620313116446,-0.122140934682823,"RGS14","regulator of G-protein signaling 14",TRUE
+"209324_s_at",0.538508613666048,0.0439529847263683,-2.13622378683499,-3.93220580554179,-1.73940640454666,"RGS16","regulator of G-protein signaling 16",TRUE
+"242212_at",0.539609110035715,0.0444432647054816,2.13081698461332,-3.94139943220244,0.673318082131092,"RGS16","regulator of G-protein signaling 16",TRUE
+"209325_s_at",0.597654932724127,0.0743921361492819,-1.8725144753478,-4.36252028224134,-1.32023511133522,"RGS16","regulator of G-protein signaling 16",TRUE
+"220334_at",0.633963464516753,0.104838144479111,1.69109872528917,-4.63520504907421,1.98883465395931,"RGS17","regulator of G-protein signaling 17",TRUE
+"223809_at",0.841550580403629,0.433115728580896,0.79839568897603,-5.63389157029688,0.508251715554319,"RGS18","regulator of G-protein signaling 18",TRUE
+"204336_s_at",0.988776423002819,0.946034679495013,-0.0684585456479124,-5.93740108186572,-0.0293874270818364,"RGS19","regulator of G-protein signaling 19",TRUE
+"202388_at",0.726636642789909,0.206080255756899,1.30262488091968,-5.14537678176249,0.983006288289435,"RGS2","regulator of G-protein signaling 2",TRUE
+"210138_at",0.61362348304466,0.0847793651745654,1.80440824588503,-4.46725795390241,2.13548267834784,"RGS20","regulator of G-protein signaling 20",TRUE
+"1569303_s_at",0.899889458546239,0.593928784640775,0.540965837773912,-5.79814380652627,0.455186541955651,"RGS20","regulator of G-protein signaling 20",TRUE
+"223691_at",0.697713925841949,0.168701931406137,-1.42286975496159,-4.99895254102363,-1.23806742271798,"RGS22","regulator of G-protein signaling 22",TRUE
+"203823_at",0.686162889425718,0.154910370898703,-1.47264700408669,-4.93522978755783,-0.602749280898166,"RGS3","regulator of G-protein signaling 3",TRUE
+"232223_at",0.930908124163614,0.694593433606176,0.397787555310875,-5.86290557784986,0.23992629044857,"RGS3","regulator of G-protein signaling 3",TRUE
+"220300_at",0.937113154905832,0.720850445541143,0.361906699270481,-5.87609024674366,0.188236607644246,"RGS3","regulator of G-protein signaling 3",TRUE
+"204339_s_at",0.767727587789514,0.270217644250963,1.13083344337015,-5.33531879650247,1.22638113367344,"RGS4","regulator of G-protein signaling 4",TRUE
+"204338_s_at",0.875938621758472,0.524388259314676,0.646827792615281,-5.73793208002855,1.03228269883866,"RGS4","regulator of G-protein signaling 4",TRUE
+"204337_at",0.903021267024792,0.602881346922905,0.527804414644951,-5.80490198785719,0.75705822478371,"RGS4","regulator of G-protein signaling 4",TRUE
+"209071_s_at",0.418769817352331,0.0171588070670602,-2.57656512113579,-3.1386107980408,-2.04641796714643,"RGS5","regulator of G-protein signaling 5",TRUE
+"209070_s_at",0.657015752622694,0.125968708508486,-1.59015280914828,-4.77786780738633,-1.21917605401218,"RGS5","regulator of G-protein signaling 5",TRUE
+"230678_at",0.918079643145802,0.652134597180677,0.456979468300622,-5.83847866073051,0.270939182832884,"RGS5","regulator of G-protein signaling 5",TRUE
+"1555725_a_at",0.952697366942815,0.783492881726918,-0.278128232618003,-5.90207663412178,-0.14397442430893,"RGS5","regulator of G-protein signaling 5",TRUE
+"1558785_a_at",0.959888304606767,0.818621313504488,0.232060071980626,-5.91348820216999,0.0953017718851887,"RGS5","regulator of G-protein signaling 5",TRUE
+"218353_at",0.960588243569671,0.820914232844863,-0.22907195433719,-5.91415761903316,-0.261501022818581,"RGS5","regulator of G-protein signaling 5",TRUE
+"214538_x_at",0.559167054471987,0.0528551291086853,2.04553460054473,-4.08442920250521,0.743983621118419,"RGS6","regulator of G-protein signaling 6",TRUE
+"236726_at",0.842397669245069,0.436289647560611,0.792821303157676,-5.63808371321003,0.190984848002401,"RGS6","regulator of G-protein signaling 6",TRUE
+"210270_at",0.877223961993707,0.526555334933882,0.643420504663532,-5.7400311721905,0.203347995372599,"RGS6","regulator of G-protein signaling 6",TRUE
+"211448_s_at",0.966593471043185,0.844333731147618,-0.198668520570289,-5.92047776174005,-0.0692797260575326,"RGS6","regulator of G-protein signaling 6",TRUE
+"216970_at",0.833184482935234,0.410540725307314,-0.838799083750877,-5.6026837010033,-0.574702389930624,"RGS7","regulator of G-protein signaling 7",TRUE
+"206290_s_at",0.869574215769297,0.50698522681441,0.674476936155587,-5.72050545127034,0.794377205479001,"RGS7","regulator of G-protein signaling 7",TRUE
+"1554500_a_at",0.973071267819624,0.869636083379211,0.166033825601139,-5.9262654117007,0.201597753697953,"RGS7","regulator of G-protein signaling 7",TRUE
+"237719_x_at",0.7717895132349,0.281184942771114,1.10459895785103,-5.36225484566377,1.02378510415973,"RGS7BP","regulator of G-protein signaling 7 binding protein",TRUE
+"244675_at",0.656793097494112,0.124931837474874,-1.594761569285,-4.77150217998649,-1.21422364909386,"RGS8","regulator of G-protein signaling 8",TRUE
+"224390_s_at",0.913299709879835,0.636361513444576,0.479386463333511,-5.82836648079769,0.172067021367434,"RGS8","regulator of G-protein signaling 8",TRUE
+"206518_s_at",0.789661545166663,0.317427526599337,1.02282829081213,-5.44258371345139,0.358568455819577,"RGS9","regulator of G-protein signaling 9",TRUE
+"1556199_a_at",0.518141227654622,0.0370540868793703,-2.21872532863179,-3.7901290206995,-1.59789316800131,"RGS9BP","regulator of G-protein signaling 9 binding protein",TRUE
+"211446_at",0.935075628376499,0.71125606278778,0.374959111960233,-5.87143620490894,0.248731350137476,"RGSL1","regulator of G-protein signaling like 1",TRUE
+"206146_s_at",0.707593266152278,0.179011066436549,-1.38775450328009,-5.04282334939007,-0.590688616354102,"RHAG","Rh-associated glycoprotein",TRUE
+"211254_x_at",0.746784084367898,0.238694073764971,1.21089475900264,-5.24968985008938,0.456705643484184,"RHAG","Rh-associated glycoprotein",TRUE
+"206145_at",0.854184492233394,0.464009020299063,0.745156167254944,-5.6727972759707,0.408743389549539,"RHAG","Rh-associated glycoprotein",TRUE
+"236690_at",0.69887421412603,0.170179379973769,1.41773374281536,-5.00542547630846,0.527271424501911,"RHBDD1","rhomboid domain containing 1",TRUE
+"226948_at",0.897949253801113,0.586416156777817,-0.552085360331844,-5.79230803611152,-0.280071418595014,"RHBDD1","rhomboid domain containing 1",TRUE
+"233164_x_at",0.940044918888428,0.730769131974591,-0.348480081541446,-5.88070780048173,-0.137489464972433,"RHBDD1","rhomboid domain containing 1",TRUE
+"226945_at",0.954337260876625,0.789796869537087,-0.26981861007922,-5.90428634721208,-0.0989441199594054,"RHBDD1","rhomboid domain containing 1",TRUE
+"227414_at",0.955892698633978,0.800117592189922,0.256255804487743,-5.90775000392579,0.113188514757099,"RHBDD1","rhomboid domain containing 1",TRUE
+"222995_s_at",0.580137756009815,0.0625726608557743,-1.96096200983665,-4.22245155871401,-0.694569357015645,"RHBDD2","rhomboid domain containing 2",TRUE
+"232053_x_at",0.710226164203618,0.183015572518789,-1.3745478123785,-5.05908816928165,-0.529910679373854,"RHBDD2","rhomboid domain containing 2",TRUE
+"204402_at",0.898609426925686,0.58819814461082,-0.549441498599733,-5.79370604477688,-0.203291002575567,"RHBDD3","rhomboid domain containing 3",TRUE
+"217622_at",0.966593471043185,0.844458251781703,0.198507403314633,-5.92050887069292,0.077308931858699,"RHBDD3","rhomboid domain containing 3",TRUE
+"218686_s_at",0.545412722791443,0.0470207033282668,-2.10324707295914,-3.98804850865429,-0.886308877702042,"RHBDF1","rhomboid 5 homolog 1",TRUE
+"222711_s_at",0.95877806139143,0.813334892828457,-0.23895759031032,-5.91191002624587,-0.130054826609512,"RHBDF1","rhomboid 5 homolog 1",TRUE
+"219202_at",0.569677533019345,0.0589109606162117,1.99136309484138,-4.17328688972498,0.672519879199267,"RHBDF2","rhomboid 5 homolog 2",TRUE
+"207383_s_at",0.94118897722809,0.73679863613318,0.340350085903056,-5.88341993079307,0.254178659019982,"RHBDL1","rhomboid like 1",TRUE
+"1552502_s_at",0.540215685291847,0.0446301646175267,2.12877000072081,-3.94487624169147,1.92768158409526,"RHBDL2","rhomboid like 2",TRUE
+"1554895_a_at",0.599731655615302,0.0761892513344404,1.86016268198326,-4.38172066705137,1.89679275914956,"RHBDL2","rhomboid like 2",TRUE
+"1554897_s_at",0.635368778245437,0.106174204295998,1.68422992894564,-4.64512444836871,1.79853475612754,"RHBDL2","rhomboid like 2",TRUE
+"230755_at",0.778031107955451,0.297393909188767,-1.06715091899721,-5.39972903864953,-0.352911485574019,"RHBDL3","rhomboid like 3",TRUE
+"1553268_at",0.875938621758472,0.524196996096798,-0.647128885008813,-5.73774607714598,-0.462942878499747,"RHBDL3","rhomboid like 3",TRUE
+"233409_at",0.886783047600321,0.549975646898986,0.607069832965679,-5.76176095064204,0.263445749367524,"RHBDL3","rhomboid like 3",TRUE
+"233232_at",0.912329443373872,0.632746524554011,0.484556701938602,-5.82596594398209,0.186382217573032,"RHBDL3","rhomboid like 3",TRUE
+"220510_at",0.977160030692682,0.891100050600483,0.138495256319066,-5.93034547001203,0.0788706250920628,"RHBG","Rh family B glycoprotein (gene/pseudogene)",TRUE
+"219554_at",0.0925545494931958,0.000366192283217054,4.19924236496719,0.229552460159938,2.6203164636762,"RHCG","Rh family C glycoprotein",TRUE
+"210429_at",0.812302873476553,0.360251322397518,0.934238856698259,-5.52328643183946,0.660990586202403,"RHD","Rh blood group D antigen",TRUE
+"210586_x_at",0.84176002413858,0.43369372909289,-0.797378666958742,-5.63465846831543,-0.421650261873099,"RHD","Rh blood group D antigen",TRUE
+"210430_x_at",0.981266690607318,0.91145183141276,-0.112484910096791,-5.93352262005757,-0.0763802116214762,"RHD","Rh blood group D antigen",TRUE
+"216317_x_at",0.71242055183987,0.186474472555313,1.36332350856126,-5.07280986752334,1.05832500292556,"RHD///RHCE","Rh blood group D antigen///Rh blood group CcEe antigens",TRUE
+"215819_s_at",0.962741248200658,0.830266109317528,0.21690639585927,-5.91679389307002,0.0887641580512426,"RHD///RHCE","Rh blood group D antigen///Rh blood group CcEe antigens",TRUE
+"243008_at",0.769258076576208,0.275561431463243,1.11795566275068,-5.34861091975805,0.859973633917515,"RHEB","Ras homolog enriched in brain",TRUE
+"241795_at",0.778580821633075,0.298878793002541,1.06379426852126,-5.40303162472646,0.334672335463011,"RHEB","Ras homolog enriched in brain",TRUE
+"213409_s_at",0.816800680706682,0.367950078313017,0.91908308993656,-5.53642226285509,0.342845374254434,"RHEB","Ras homolog enriched in brain",TRUE
+"201453_x_at",0.870808709484996,0.510214307572973,-0.669307288439275,-5.72381687810356,-0.20253694673487,"RHEB","Ras homolog enriched in brain",TRUE
+"213404_s_at",0.896229101808264,0.579596614278313,-0.562240303690673,-5.78687780044329,-0.187953941203336,"RHEB","Ras homolog enriched in brain",TRUE
+"201452_at",0.929126743655924,0.68845630326729,-0.406249513367665,-5.85961736235283,-0.21832917589981,"RHEB","Ras homolog enriched in brain",TRUE
+"201451_x_at",0.942835367370539,0.74384678814666,0.330876094062329,-5.88650052528278,0.214128084583517,"RHEB","Ras homolog enriched in brain",TRUE
+"227633_at",0.942855851720963,0.743903351285577,-0.330800188925949,-5.88652485943043,-0.309820918074894,"RHEB","Ras homolog enriched in brain",TRUE
+"1555780_a_at",0.951339758531576,0.777329313321912,-0.286272141153958,-5.899846449106,-0.098353717512758,"RHEB","Ras homolog enriched in brain",TRUE
+"1570253_a_at",0.680972290639028,0.148948287585773,1.49528379381718,-4.90566481691881,1.15480995177894,"RHEBL1","Ras homolog enriched in brain like 1",TRUE
+"1553713_a_at",0.728385463227073,0.209201795863911,1.29338108780782,-5.15618301613735,0.924791794681316,"RHEBL1","Ras homolog enriched in brain like 1",TRUE
+"225836_s_at",0.83672962069254,0.418490593273125,-0.824415401228621,-5.6139591653048,-0.316441066441877,"RHNO1","RAD9-HUS1-RAD1 interacting nuclear orphan 1",TRUE
+"225837_at",0.940044918888428,0.731679041028183,-0.347251667164444,-5.88112165278306,-0.117322283214301,"RHNO1","RAD9-HUS1-RAD1 interacting nuclear orphan 1",TRUE
+"206455_s_at",0.678611044120554,0.146066623086913,1.50649066664526,-4.89089392980764,0.713306005534565,"RHO","rhodopsin",TRUE
+"206454_s_at",0.726696341943087,0.206934654906225,1.30008402390899,-5.14835361461223,0.83308945665096,"RHO","rhodopsin",TRUE
+"200059_s_at",0.849935057946582,0.451828129274186,-0.765883527734691,-5.65795170820872,-0.226618635555949,"RHOA","ras homolog family member A",TRUE
+"1555814_a_at",0.925091998149497,0.675622361662565,-0.424044011238897,-5.85248051385922,-0.147606147303817,"RHOA","ras homolog family member A",TRUE
+"240337_at",0.945664467195782,0.754814532655183,-0.31619429652303,-5.89110445441046,-0.326764925283921,"RHOA","ras homolog family member A",TRUE
+"212099_at",0.307916971162643,0.00620057769090205,-3.02431205912139,-2.25870258849735,-2.48607482563251,"RHOB","ras homolog family member B",TRUE
+"1553962_s_at",0.384135218769668,0.012363822713695,-2.72329779822942,-2.85709456979669,-2.49623235277521,"RHOB","ras homolog family member B",TRUE
+"1553963_at",0.816800680706682,0.368211205468061,0.918572761414434,-5.53686113291809,0.663575050797575,"RHOB","ras homolog family member B",TRUE
+"1553965_x_at",0.838287089408256,0.422969196257842,-0.816387972379998,-5.6201725235264,-0.53798366244039,"RHOB","ras homolog family member B",TRUE
+"226417_at",0.924874199396311,0.67502706770754,0.424872740484004,-5.85214080564826,0.205348184911403,"RHOB","ras homolog family member B",TRUE
+"212651_at",0.76469251347209,0.264761349175312,-1.14417640439797,-5.32140482247805,-1.21283463919193,"RHOBTB1","Rho related BTB domain containing 1",TRUE
+"1554586_a_at",0.870084233343568,0.508300828978677,0.672368480946084,-5.7218589711172,0.350024879467211,"RHOBTB2","Rho related BTB domain containing 2",TRUE
+"209441_at",0.989586772349659,0.949585909427006,0.0639469283345909,-5.937691973753,0.0513155032960952,"RHOBTB2","Rho related BTB domain containing 2",TRUE
+"202975_s_at",0.863559206655094,0.488662698209199,0.704169625354515,-5.70101437689137,0.694975394013293,"RHOBTB3","Rho related BTB domain containing 3",TRUE
+"202976_s_at",0.868397087637799,0.504145740714086,0.679038155550132,-5.71756350989489,0.79622778043481,"RHOBTB3","Rho related BTB domain containing 3",TRUE
+"225202_at",0.869239416336493,0.506297182490205,0.675580856771271,-5.71979517347811,0.736055841412776,"RHOBTB3","Rho related BTB domain containing 3",TRUE
+"216048_s_at",0.899755026004388,0.591443907354325,0.544636033263876,-5.79623036247316,0.650428442309954,"RHOBTB3","Rho related BTB domain containing 3",TRUE
+"216049_at",0.936992192746977,0.718027345792304,-0.365740558143871,-5.87474010565897,-0.187085730989188,"RHOBTB3","Rho related BTB domain containing 3",TRUE
+"240111_at",0.937856707467078,0.725129172019688,0.356106550186668,-5.87810613351066,0.16910948566932,"RHOBTB3","Rho related BTB domain containing 3",TRUE
+"200885_at",0.0657210807339444,0.000155062083487496,-4.54982686051651,0.986502558143051,-1.43403384978401,"RHOC","ras homolog family member C",TRUE
+"235742_at",0.614663663463974,0.0854668544512077,-1.8001608042736,-4.47369740925765,-1.19788900715007,"RHOC","ras homolog family member C",TRUE
+"31846_at",0.957571530817866,0.809578484572264,0.243865999841725,-5.9107589715438,0.12232062860862,"RHOD","ras homolog family member D",TRUE
+"209885_at",0.975398143273847,0.882348172730197,-0.149709566286993,-5.92877284957966,-0.108550379589376,"RHOD","ras homolog family member D",TRUE
+"222812_s_at",0.291020678465228,0.00508808581895705,3.10895548910231,-2.08617292479626,1.30611919315998,"RHOF","ras homolog family member F, filopodia associated",TRUE
+"1554539_a_at",0.587626678796111,0.0664251596851633,1.93062878681569,-4.27099192250067,1.0803358330642,"RHOF","ras homolog family member F, filopodia associated",TRUE
+"219045_at",0.587626678796111,0.0666374787586273,1.92900254041322,-4.2735796129854,1.50345075624581,"RHOF","ras homolog family member F, filopodia associated",TRUE
+"1554538_at",0.686108994812404,0.154802039316153,1.47305194683239,-4.93470410586377,0.476819008832054,"RHOF","ras homolog family member F, filopodia associated",TRUE
+"203175_at",0.98529096111871,0.92671684042893,0.0930286928655712,-5.93546915085601,0.0321144371234112,"RHOG","ras homolog family member G",TRUE
+"204951_at",0.545085128927207,0.0469114576531861,-2.10438771692161,-3.98612619365716,-2.1701351753036,"RHOH","ras homolog family member H",TRUE
+"236293_at",0.927909601142037,0.683599409046527,-0.412967691354098,-5.85695825431925,-0.349839445457678,"RHOH","ras homolog family member H",TRUE
+"238906_s_at",0.358427723880268,0.0100911844648482,-2.81290797203051,-2.68168255113428,-1.98451495320857,"RHOJ","ras homolog family member J",TRUE
+"1555234_a_at",0.50789985308763,0.0334172968415094,-2.26801954997347,-3.70368010841075,-1.38336692045692,"RHOJ","ras homolog family member J",TRUE
+"1555233_at",0.748184017928985,0.240589103039219,1.20586558100088,-5.25521899830051,0.891507094129685,"RHOJ","ras homolog family member J",TRUE
+"235489_at",0.873230718105642,0.517840270400532,-0.657170393603315,-5.73149524680806,-0.585023183819206,"RHOJ","ras homolog family member J",TRUE
+"238905_at",0.912906062613339,0.634674115371471,-0.481798160050351,-5.82724986571356,-0.395224627447983,"RHOJ","ras homolog family member J",TRUE
+"243481_at",0.915742010892393,0.644481845997771,0.467820476582545,-5.8336453287054,0.467736449637285,"RHOJ","ras homolog family member J",TRUE
+"235131_at",0.95952608973576,0.817137743258929,0.233994601093034,-5.91305021437993,0.0932473198940151,"RHOJ","ras homolog family member J",TRUE
+"212119_at",0.812125226040016,0.356327783525661,0.942046335446163,-5.516442479493,0.383079932822163,"RHOQ","ras homolog family member Q",TRUE
+"1559582_at",0.815195559141692,0.366085721745301,0.92273368353779,-5.53327629387458,0.281831993972046,"RHOQ","ras homolog family member Q",TRUE
+"212117_at",0.825808541732306,0.393412076106048,0.870404535632138,-5.57726928369309,0.375358609165149,"RHOQ","ras homolog family member Q",TRUE
+"212120_at",0.91876780831279,0.654949782475349,0.453005449782767,-5.8402226136287,0.234988727515132,"RHOQ","ras homolog family member Q",TRUE
+"212122_at",0.940044918888428,0.731371189602063,0.347667218100107,-5.88098181551433,0.223733915081423,"RHOQ","ras homolog family member Q",TRUE
+"214449_s_at",0.949179181265614,0.770592876049713,0.29519567073146,-5.89732946194057,0.13317744703987,"RHOQ","ras homolog family member Q",TRUE
+"224044_at",0.635174103121116,0.106013950314604,-1.68504992841828,-4.64394186939621,-0.939896426017553,"RHOT1","ras homolog family member T1",TRUE
+"222148_s_at",0.871744769522775,0.513911744411698,-0.663410227417629,-5.72756445437993,-0.274459456910805,"RHOT1","ras homolog family member T1",TRUE
+"218323_at",0.90261448949227,0.601870878135626,-0.529285176120728,-5.80414972639822,-0.217802356187248,"RHOT1","ras homolog family member T1",TRUE
+"222131_x_at",0.6122079201328,0.0837817941331867,-1.81062468008542,-4.45781355654455,-0.528014008270775,"RHOT2","ras homolog family member T2",TRUE
+"221789_x_at",0.628892275677877,0.0999441240670337,-1.71691143608616,-4.59765711570066,-0.474075141904251,"RHOT2","ras homolog family member T2",TRUE
+"65770_at",0.786455312223125,0.311998344198161,-1.03463993603028,-5.43132321237829,-0.286742779410547,"RHOT2","ras homolog family member T2",TRUE
+"223168_at",0.199949563712201,0.00222714740376279,-3.45694561375323,-1.36184396504221,-3.25550779503357,"RHOU","ras homolog family member U",TRUE
+"223169_s_at",0.380731642340006,0.011918909225306,-2.73953688425044,-2.82549358969732,-2.47293025217909,"RHOU","ras homolog family member U",TRUE
+"241990_at",0.986342822130003,0.934820510611148,-0.0827154716621611,-5.93635161758648,-0.093801299062747,"RHOV","ras homolog family member V",TRUE
+"1552724_at",0.97689149311934,0.889677736630534,0.140316477175181,-5.93009838166526,0.0389863966629385,"RHOXF1","Rhox homeobox family member 1",TRUE
+"236920_at",0.967315591387789,0.847133153119892,-0.195047638672608,-5.92117082399893,-0.078043679068506,"RHOXF2B///RHOXF2","Rhox homeobox family member 2B///Rhox homeobox family member 2",TRUE
+"235998_at",0.729273475042162,0.211615238669445,-1.28630710999013,-5.16440851595409,-1.01914464509749,"RHPN1","rhophilin Rho GTPase binding protein 1",TRUE
+"228405_at",0.750402030437619,0.243376811176789,1.19852125803844,-5.26325754841764,0.506457289375117,"RHPN1","rhophilin Rho GTPase binding protein 1",TRUE
+"207458_at",0.833947935066508,0.411708186404726,0.836675822866375,-5.60435960946001,0.290490285876846,"RHPN1-AS1","RHPN1 antisense RNA 1 (head to head)",TRUE
+"227196_at",0.975643571636296,0.883834039380809,0.147804290067487,-5.92904864521478,0.0629615931791303,"RHPN2","rhophilin Rho GTPase binding protein 2",TRUE
+"235946_at",0.677178016653513,0.144680714616051,-1.51194498933168,-4.8836730828162,-1.06489118820346,"RIBC1","RIB43A domain with coiled-coils 1",TRUE
+"1553318_at",0.731548533938014,0.215124895790656,1.27613040539082,-5.17617442505965,0.878161645794404,"RIBC1","RIB43A domain with coiled-coils 1",TRUE
+"206526_at",0.853399486996397,0.461676784370396,0.749099322036484,-5.67000276727661,0.729086364248071,"RIBC2","RIB43A domain with coiled-coils 2",TRUE
+"226222_at",0.843451534835573,0.43807703569026,0.789693091156911,-5.64042413633237,0.469929853981506,"RIC1","RIC1 homolog, RAB6A GEF complex partner 1",TRUE
+"223825_at",0.940323871449272,0.733262159985245,0.345115688216161,-5.88183782342195,0.307264537560553,"RIC1","RIC1 homolog, RAB6A GEF complex partner 1",TRUE
+"226221_at",0.98055399787159,0.909110108097965,-0.115473330719724,-5.93319102323141,-0.0414109431764746,"RIC1","RIC1 homolog, RAB6A GEF complex partner 1",TRUE
+"223826_s_at",0.984802091612958,0.925480737896054,0.0946027123748811,-5.93532536482913,0.0339640090566169,"RIC1","RIC1 homolog, RAB6A GEF complex partner 1",TRUE
+"220282_at",0.946277807642742,0.75671055285801,0.313663483443146,-5.89187716354805,0.168859345291421,"RIC3","RIC3 acetylcholine receptor chaperone",TRUE
+"229637_at",0.868541339434524,0.504610416446902,0.678290733868002,-5.7180468888801,0.228474141846327,"RIC8B","RIC8 guanine nucleotide exchange factor B",TRUE
+"219446_at",0.990918916504081,0.957182104451706,-0.0543008755703578,-5.93824743570844,-0.0187527577548625,"RIC8B","RIC8 guanine nucleotide exchange factor B",TRUE
+"226312_at",0.150552075411854,0.00107665041583969,3.75774986044691,-0.721699573322785,1.13631122096371,"RICTOR","RPTOR independent companion of MTOR complex 2",TRUE
+"228248_at",0.194325783329824,0.00204901388184327,3.49165014757338,-1.28852544993818,1.2634132035643,"RICTOR","RPTOR independent companion of MTOR complex 2",TRUE
+"226310_at",0.283622246282531,0.00479317705651685,3.13439580763328,-2.03400169238165,1.12116328753613,"RICTOR","RPTOR independent companion of MTOR complex 2",TRUE
+"1552734_at",0.597654932724127,0.0746502699663388,1.8707243860995,-4.36530847013398,0.934485165780653,"RICTOR","RPTOR independent companion of MTOR complex 2",TRUE
+"203790_s_at",0.620912785033482,0.0908016672787976,-1.76816706093031,-4.52184697874117,-1.01372649003519,"RIDA","reactive intermediate imine deaminase A homolog",TRUE
+"231705_at",0.980025041090473,0.906283422086427,-0.119082080799523,-5.93277902094418,-0.0815385346054249,"RIDA","reactive intermediate imine deaminase A homolog",TRUE
+"240098_at",0.723360467478293,0.199947814266108,-1.32110632336662,-5.12357630026128,-0.839082378935172,"RIF1","replication timing regulatory factor 1",TRUE
+"226503_at",0.739367922105944,0.227448623572262,-1.24137676094884,-5.21575201424737,-0.397953314648392,"RIF1","replication timing regulatory factor 1",TRUE
+"214700_x_at",0.772975577977561,0.283490036379944,-1.09918003565329,-5.36774877036194,-0.336714109541395,"RIF1","replication timing regulatory factor 1",TRUE
+"214872_at",0.796466121438385,0.32907704388449,0.997952635879172,-5.4659159110687,0.498196072179188,"RIF1","replication timing regulatory factor 1",TRUE
+"233781_s_at",0.817055852876968,0.369430841239147,0.916192373564416,-5.53890524050675,0.44351141958523,"RIF1","replication timing regulatory factor 1",TRUE
+"236620_at",0.822850703882235,0.388296272177728,0.880015689345419,-5.56936753310697,0.349848941773915,"RIF1","replication timing regulatory factor 1",TRUE
+"226821_at",0.855405088766616,0.468185205937752,0.738124754080232,-5.67774573206151,0.307986236755006,"RIF1","replication timing regulatory factor 1",TRUE
+"241820_at",0.860771082151018,0.480691415829057,0.717286790460904,-5.69214902778887,0.201635594690714,"RIF1","replication timing regulatory factor 1",TRUE
+"233780_at",0.872533419431374,0.515748240497177,0.660489967269213,-5.72940850995032,0.637715000427272,"RIF1","replication timing regulatory factor 1",TRUE
+"237131_at",0.812224812938422,0.356502442814746,-0.941697552970908,-5.51674933410167,-0.436086752785421,"RIIAD1","regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1",TRUE
+"227366_at",0.724970327905974,0.20297680077688,1.31192349993429,-5.13444069743605,0.430824342355326,"RILP","Rab interacting lysosomal protein",TRUE
+"226207_at",0.775351898377291,0.292040199622242,-1.07935369477012,-5.38764440874013,-0.382276762115227,"RILPL1","Rab interacting lysosomal protein like 1",TRUE
+"1554017_at",0.83040144083154,0.402830131050296,0.852919798890899,-5.59143726137553,0.566462240947343,"RILPL1///SNRNP35","Rab interacting lysosomal protein like 1///small nuclear ribonucleoprotein U11/U12 subunit 35",TRUE
+"227983_at",0.993225426079816,0.968501515610779,0.0399363901092801,-5.93890668618917,0.0223109049399692,"RILPL2","Rab interacting lysosomal protein like 2",TRUE
+"241771_at",0.683017520100356,0.151403685730727,1.48587341514737,-4.91799944366314,0.526905022495884,"RIMBP2","RIMS binding protein 2",TRUE
+"214811_at",0.705100208997726,0.176842366065969,-1.39500502171443,-5.03383913183846,-0.806208316176816,"RIMBP2","RIMS binding protein 2",TRUE
+"237995_at",0.885029460971826,0.546017111595585,0.613154965280662,-5.75820820645389,0.536042825401329,"RIMBP2","RIMS binding protein 2",TRUE
+"238817_at",0.890816525789205,0.559669430812561,-0.592264789110443,-5.77026182665636,-0.316667573117148,"RIMBP2","RIMS binding protein 2",TRUE
+"230062_at",0.997171203405,0.98574088985089,-0.0180748893964168,-5.93952435768487,-0.00634292999041719,"RIMBP3B///RIMBP3C///RIMBP3","RIMS binding protein 3B///RIMS binding protein 3C///RIMS binding protein 3",TRUE
+"235948_at",0.468732760220321,0.0247726934638911,-2.40846978563725,-3.4513534548512,-1.0797019585954,"RIMKLA","ribosomal modification protein rimK like family member A",TRUE
+"236884_at",0.706789484222586,0.178587960210974,-1.38916354862453,-5.04108041555411,-0.931728168657498,"RIMKLA","ribosomal modification protein rimK like family member A",TRUE
+"236376_at",0.821644619977332,0.384275712436038,0.887627180941151,-5.56305268480595,0.51652254954653,"RIMKLA","ribosomal modification protein rimK like family member A",TRUE
+"241075_at",0.99443717604727,0.974414397653751,-0.0324364817352073,-5.93917104227683,-0.0177442767584521,"RIMKLA","ribosomal modification protein rimK like family member A",TRUE
+"225978_at",0.705559553212919,0.17742369477892,1.39305458211747,-5.03625975665699,0.972353024223817,"RIMKLB","ribosomal modification protein rimK like family member B",TRUE
+"226164_x_at",0.732963666545614,0.217142587283995,1.27033763079469,-5.18283619467915,0.746136732052312,"RIMKLB","ribosomal modification protein rimK like family member B",TRUE
+"236911_at",0.746259710622309,0.237778833175534,1.21333448341991,-5.24700039677251,0.616310358420027,"RIMKLB","ribosomal modification protein rimK like family member B",TRUE
+"229344_x_at",0.818245799872725,0.371222442905221,0.912705117348978,-5.54189101753821,0.484970541286149,"RIMKLB","ribosomal modification protein rimK like family member B",TRUE
+"225999_at",0.822372058422737,0.387177162436953,0.882129139864617,-5.56761917302587,0.554543500201832,"RIMKLB","ribosomal modification protein rimK like family member B",TRUE
+"231986_at",0.709431919391341,0.182460569739022,1.37636442230502,-5.0568585670218,0.734819429905451,"RIMS1","regulating synaptic membrane exocytosis 1",TRUE
+"1552922_at",0.841550580403629,0.433312157936982,-0.798049967223127,-5.63415236916958,-0.513901470727026,"RIMS1","regulating synaptic membrane exocytosis 1",TRUE
+"216184_s_at",0.953564723226096,0.786249475028557,0.274492193867004,-5.90305172492135,0.191297530366944,"RIMS1","regulating synaptic membrane exocytosis 1",TRUE
+"215478_at",0.943400587031071,0.745991546252302,-0.327999309820485,-5.88741891966062,-0.12789535318544,"RIMS2","regulating synaptic membrane exocytosis 2",TRUE
+"206137_at",0.961212424803935,0.823750846884774,0.225378242916177,-5.91497317702722,0.187652999469966,"RIMS2","regulating synaptic membrane exocytosis 2",TRUE
+"229823_at",0.980459547037842,0.908818638646993,0.11584536806664,-5.93314913398027,0.146804800120781,"RIMS2","regulating synaptic membrane exocytosis 2",TRUE
+"210991_s_at",0.520481716530016,0.03771874315645,2.21019599104017,-3.80497078956946,0.968738104760005,"RIMS3","regulating synaptic membrane exocytosis 3",TRUE
+"204730_at",0.703902004301726,0.175459461695287,1.39966546596743,-5.02804387990648,0.738075622511017,"RIMS3","regulating synaptic membrane exocytosis 3",TRUE
+"227644_at",0.726636642789909,0.205992668045949,1.30288581557409,-5.14507079543618,1.21128748518453,"RIMS4","regulating synaptic membrane exocytosis 4",TRUE
+"233299_at",0.933815609540291,0.706737704098633,0.381128902252793,-5.86917965355754,0.239155654047883,"RIMS4","regulating synaptic membrane exocytosis 4",TRUE
+"205211_s_at",0.815597868780927,0.366455916679876,0.922007821425505,-5.53390273428881,0.38994310906874,"RIN1","Ras and Rab interactor 1",TRUE
+"209684_at",0.723973974120865,0.200941538791037,1.31808181919421,-5.12716172166838,1.15706923299081,"RIN2","Ras and Rab interactor 2",TRUE
+"233811_at",0.859502367311367,0.477454154549261,0.722649951789809,-5.68847944705598,0.346008270233042,"RIN2","Ras and Rab interactor 2",TRUE
+"219457_s_at",0.358427723880268,0.0101939663581859,2.80845902118347,-2.69044963553406,3.11116696737059,"RIN3","Ras and Rab interactor 3",TRUE
+"219456_s_at",0.438309018314998,0.0200930683348625,2.50482344055201,-3.27343635722831,2.61900738896323,"RIN3","Ras and Rab interactor 3",TRUE
+"60471_at",0.524469554180848,0.0390702239447388,2.19326589978346,-3.83432714570486,1.64740539811812,"RIN3","Ras and Rab interactor 3",TRUE
+"1562005_at",0.639705117673934,0.110242017964467,1.66375819845587,-4.67450670940112,1.00948394112247,"RIN3","Ras and Rab interactor 3",TRUE
+"222069_s_at",0.812302873476553,0.359366954443652,0.935993659083384,-5.52175274804529,0.452070857786844,"RIN3","Ras and Rab interactor 3",TRUE
+"220439_at",0.907610731888632,0.616942896216571,0.50731992079415,-5.81509788098491,0.170413334177022,"RIN3","Ras and Rab interactor 3",TRUE
+"208371_s_at",0.837277736441724,0.419840995377893,-0.821989291123283,-5.61584301869422,-0.240334402174845,"RING1","ring finger protein 1",TRUE
+"35685_at",0.98529096111871,0.927102053905719,-0.0925382218489175,-5.93551346261391,-0.0244092936613622,"RING1","ring finger protein 1",TRUE
+"218598_at",0.905093805657023,0.610729323678181,-0.516344067937778,-5.81065469047891,-0.169223502286375,"RINT1","RAD50 interactor 1",TRUE
+"224450_s_at",0.637485146909712,0.108890334641708,1.6704887868691,-4.66487665018021,0.722394415752657,"RIOK1","RIO kinase 1",TRUE
+"222663_at",0.485255613602953,0.0280616906479088,-2.35038492958445,-3.55675311416462,-1.2082041283976,"RIOK2","RIO kinase 2",TRUE
+"218535_s_at",0.502810516099457,0.0325182987641094,-2.2809584022262,-3.68080173826852,-0.646146960827268,"RIOK2","RIO kinase 2",TRUE
+"202131_s_at",0.595019326272843,0.0718590624967328,1.89037465521942,-4.33459910949859,0.687895307595667,"RIOK3","RIO kinase 3",TRUE
+"202129_s_at",0.687734660055697,0.157000048339133,1.46488039399545,-4.94528947689329,0.65733014329729,"RIOK3","RIO kinase 3",TRUE
+"202130_at",0.734730148360473,0.219452474664436,1.26375654114662,-5.19037310315347,0.459790886958372,"RIOK3","RIO kinase 3",TRUE
+"215588_x_at",0.797612393661522,0.331228422321415,0.993425930465224,-5.47010570710966,0.426493529109157,"RIOK3","RIO kinase 3",TRUE
+"240583_at",0.801455134542848,0.338126757798918,0.979046618827228,-5.48329986014406,0.744606060344721,"RIOK3","RIO kinase 3",TRUE
+"209941_at",0.79484155322319,0.327022601550172,1.00229455258623,-5.46188090467199,0.377253962614079,"RIPK1","receptor interacting serine/threonine kinase 1",TRUE
+"226551_at",0.899998627338565,0.594583455292114,0.540000132622921,-5.79864518367649,0.170699999870971,"RIPK1","receptor interacting serine/threonine kinase 1",TRUE
+"209545_s_at",0.950926616697165,0.775935374074883,0.288116674236488,-5.89933245973051,0.167767355874608,"RIPK2","receptor interacting serine/threonine kinase 2",TRUE
+"209544_at",0.979588787486838,0.901623731828684,0.125034536895147,-5.9320717808795,0.0761347547363496,"RIPK2","receptor interacting serine/threonine kinase 2",TRUE
+"228139_at",0.597879550155311,0.0753195321229085,1.86610826527988,-4.37248970531995,0.610016916519433,"RIPK3","receptor interacting serine/threonine kinase 3",TRUE
+"221215_s_at",0.0681210092794308,0.000184344247961124,4.47922685580542,0.83429605519478,2.47910559602588,"RIPK4","receptor interacting serine/threonine kinase 4",TRUE
+"234730_s_at",0.0923821310498588,0.000362835754462424,4.20299988582524,0.237672321638345,3.04046805665884,"RIPK4","receptor interacting serine/threonine kinase 4",TRUE
+"1560291_at",0.966406871809324,0.843438557091858,0.199826944995536,-5.92025334976883,0.141164597648082,"RIPPLY1","ripply transcriptional repressor 1",TRUE
+"236771_at",0.846506765330126,0.44470388134875,0.778162908852941,-5.64897534975873,0.755658432780729,"RIPPLY2","ripply transcriptional repressor 2",TRUE
+"207267_s_at",0.842038788192302,0.435180430506628,0.794766578957684,-5.63662393277805,0.776615564911957,"RIPPLY3","ripply transcriptional repressor 3",TRUE
+"236223_s_at",0.826140850652187,0.39416212245552,-0.869002234733748,-5.57841543810119,-0.673600858055785,"RIT1","Ras like without CAAX 1",TRUE
+"236224_at",0.851319596585235,0.454605953077701,-0.761127438715697,-5.66139222133758,-0.615293267190447,"RIT1","Ras like without CAAX 1",TRUE
+"239843_at",0.896229101808264,0.58000553950268,-0.561629699125891,-5.78720702738014,-0.32975513524004,"RIT1","Ras like without CAAX 1",TRUE
+"243463_s_at",0.941306621461417,0.737212488875173,-0.339792922882707,-5.88360348015148,-0.231843644550342,"RIT1","Ras like without CAAX 1",TRUE
+"209882_at",0.983051865094694,0.917610302399013,0.104630630077254,-5.93435272996778,0.0568925603858155,"RIT1","Ras like without CAAX 1",TRUE
+"206984_s_at",0.565043084457947,0.0564232749331665,-2.01298774722152,-4.13800620299742,-1.29010681556426,"RIT2","Ras like without CAAX 2",TRUE
+"221777_at",0.245492559900582,0.00333497837157343,-3.28789697854429,-1.71641177621384,-1.42311126993272,"RITA1","RBPJ interacting and tubulin associated 1",TRUE
+"44065_at",0.390513636917105,0.0130613465371655,-2.69891861412789,-2.90437525844565,-0.76590610214452,"RITA1","RBPJ interacting and tubulin associated 1",TRUE
+"206154_at",0.575270671804438,0.0608909919867662,-1.97472282900848,-4.20026096299451,-0.971073135268153,"RLBP1","retinaldehyde binding protein 1",TRUE
+"204243_at",0.834454640870101,0.412779451464325,0.8347308702714,-5.60589129413441,0.231244827943542,"RLF","rearranged L-myc fusion",TRUE
+"225416_at",0.916107385524794,0.646277915822446,-0.465271068740646,-5.83479193260331,-0.132270557524295,"RLIM","ring finger protein, LIM domain interacting",TRUE
+"222815_at",0.91994485246627,0.659108370140944,-0.447148538778145,-5.84276562518546,-0.143242015208221,"RLIM","ring finger protein, LIM domain interacting",TRUE
+"215823_x_at",0.873481606879925,0.518784969734098,0.655673803350792,-5.73243272925414,0.21023569374783,"RLIM///PABPC1","ring finger protein, LIM domain interacting///poly(A) binding protein cytoplasmic 1",TRUE
+"211753_s_at",0.967701855457407,0.848101820085502,-0.193795350502427,-5.92140756483985,-0.0965758260554441,"RLN1","relaxin 1",TRUE
+"214519_s_at",0.912252515563073,0.632578502469918,0.484797335910882,-5.82585360469828,0.422584812024295,"RLN2","relaxin 2",TRUE
+"1553403_at",0.497725944448536,0.030797503313169,2.30666545780972,-3.63512049567706,0.863803864755475,"RLN3","relaxin 3",TRUE
+"229843_at",0.485571841560871,0.0281566956548524,2.34880226846451,-3.55960470872249,1.68283341679207,"RMDN1","regulator of microtubule dynamics 1",TRUE
+"222665_at",0.658628943051408,0.126871148206995,-1.58616720979941,-4.78336113845722,-0.723190452844072,"RMDN1","regulator of microtubule dynamics 1",TRUE
+"218549_s_at",0.778481681746654,0.298469577892169,-1.06471812827236,-5.40212357471329,-0.475809632870524,"RMDN1","regulator of microtubule dynamics 1",TRUE
+"1560042_at",0.654623800601032,0.123604380562592,1.60070869428327,-4.76326681504229,1.02113521900976,"RMDN2","regulator of microtubule dynamics 2",TRUE
+"235349_at",0.830592576740524,0.403043256810324,0.852527184147809,-5.5917523256397,0.823240047587743,"RMDN2","regulator of microtubule dynamics 2",TRUE
+"1553232_at",0.960695382534282,0.821513384317367,0.22829149645024,-5.91433104044502,0.202666237383271,"RMDN2","regulator of microtubule dynamics 2",TRUE
+"218126_at",0.535697382361465,0.0429923150344335,-2.14697767165966,-3.91387648068302,-0.687903585330851,"RMDN3","regulator of microtubule dynamics 3",TRUE
+"218979_at",0.95018792835023,0.773544217940386,-0.291283159395702,-5.89844246515987,-0.0868642381999951,"RMI1","RecQ mediated genome instability 1",TRUE
+"226456_at",0.587626678796111,0.0666425367975512,-1.92896385426824,-4.27364115223544,-0.827788880917828,"RMI2","RecQ mediated genome instability 2",TRUE
+"220329_s_at",0.886023097762234,0.548459044024682,-0.609398440232898,-5.76040545408586,-0.384395591492035,"RMND1","required for meiotic nuclear division 1 homolog",TRUE
+"1555201_a_at",0.969946179106301,0.857888582702373,-0.181160477248166,-5.92371112856293,-0.106751430588854,"RMND1","required for meiotic nuclear division 1 homolog",TRUE
+"212482_at",0.657015752622694,0.126015073284672,-1.58994746237697,-4.77815109853257,-0.625029672520464,"RMND5A","required for meiotic nuclear division 5 homolog A",TRUE
+"212478_at",0.789661545166663,0.317337940044495,1.02302203873029,-5.44239994769944,0.411794715763514,"RMND5A","required for meiotic nuclear division 5 homolog A",TRUE
+"212479_s_at",0.907499845821464,0.616651747086585,-0.507741807381568,-5.81489186035847,-0.177568424945473,"RMND5A","required for meiotic nuclear division 5 homolog A",TRUE
+"218262_at",0.51470556386048,0.0352009971958045,-2.24326246933929,-3.74723975368104,-1.14130175473088,"RMND5B","required for meiotic nuclear division 5 homolog B",TRUE
+"213297_at",0.874305976196739,0.520171226448201,0.653480420224667,-5.73380298636639,0.190487955448713,"RMND5B","required for meiotic nuclear division 5 homolog B",TRUE
+"1562633_at",0.54295328972902,0.0457153593112787,2.1170350150916,-3.96476724471624,1.45313177620196,"RMST","rhabdomyosarcoma 2 associated transcript (non-protein coding)",TRUE
+"1560834_a_at",0.940394922094394,0.733499439371514,-0.344795686891753,-5.88194474017016,-0.254375127825488,"RMST","rhabdomyosarcoma 2 associated transcript (non-protein coding)",TRUE
+"229782_at",0.99783553534859,0.989865082469147,-0.0128466891133117,-5.9396030974258,-0.00918717170585959,"RMST","rhabdomyosarcoma 2 associated transcript (non-protein coding)",TRUE
+"225762_x_at",0.884044108340522,0.542698791995268,0.618273976709732,-5.75519306228958,0.354285091563142,"RNA45S5","RNA, 45S pre-ribosomal 5",TRUE
+"225767_at",0.993753494258002,0.970414343962622,0.0375099201744152,-5.93899820902839,0.0175715296328729,"RNA45S5","RNA, 45S pre-ribosomal 5",TRUE
+"201785_at",0.756910596700587,0.252358907494376,1.17527851172387,-5.28841532257333,0.805712625276019,"RNASE1","ribonuclease A family member 1, pancreatic",TRUE
+"217093_at",0.89748872632674,0.584261959378555,0.555286776702687,-5.79060648474316,0.439227446670542,"RNASE1","ribonuclease A family member 1, pancreatic",TRUE
+"231603_at",0.947778780715578,0.762323655119212,-0.306183266667267,-5.89412506328288,-0.178476698152013,"RNASE11","ribonuclease A family member 11 (inactive)",TRUE
+"206111_at",0.82849258297242,0.398574085320575,0.860788237895406,-5.58509453376924,0.448896586464175,"RNASE2","ribonuclease A family member 2",TRUE
+"206851_at",0.766390367856479,0.266889943250967,1.13894726234375,-5.32687489139497,0.438873003386156,"RNASE3","ribonuclease A family member 3",TRUE
+"213397_x_at",0.955519949210561,0.796273039204301,-0.261302182657588,-5.90648198967387,-0.374003226967433,"RNASE4","ribonuclease A family member 4",TRUE
+"205158_at",0.996917497388089,0.984281670672223,0.0199248438262964,-5.93949011882775,0.0250646906249123,"RNASE4","ribonuclease A family member 4",TRUE
+"213566_at",0.998709719538178,0.994305461858843,-0.00721806781470083,-5.93965810454688,-0.00282309563686578,"RNASE6","ribonuclease A family member k6",TRUE
+"234700_s_at",0.593339168375633,0.0703241471311379,1.90146689591913,-4.31716493524736,1.70025946038187,"RNASE7","ribonuclease A family member 7",TRUE
+"233488_at",0.642592458809121,0.112502320996803,1.65265724465291,-4.69032512138213,1.45596962164837,"RNASE7","ribonuclease A family member 7",TRUE
+"234699_at",0.692340944314652,0.16191977421036,1.44692059904088,-4.968386465288,0.984691410558957,"RNASE7","ribonuclease A family member 7",TRUE
+"241343_at",0.585892284764425,0.0658863743968596,1.93477621056732,-4.26438572172861,0.687760723552573,"RNASEH1","ribonuclease H1",TRUE
+"218496_at",0.650490742096872,0.120556424614884,1.61456816824424,-4.74398242186384,0.551717104772637,"RNASEH1","ribonuclease H1",TRUE
+"218497_s_at",0.769774279128662,0.277253910147381,1.11391506531575,-5.35275374499722,0.400856234716819,"RNASEH1","ribonuclease H1",TRUE
+"232790_at",0.575051277842416,0.0606761924439488,-1.97650464229049,-4.19737993217788,-1.15339776998051,"RNASEH1-AS1","RNASEH1 antisense RNA 1",TRUE
+"203022_at",0.975196332002567,0.87928250100228,0.153642374818353,-5.92819241480425,0.0610304825388699,"RNASEH2A","ribonuclease H2 subunit A",TRUE
+"219056_at",0.645740804644555,0.116783847920829,1.63213446778022,-4.71935574144756,0.944292171344994,"RNASEH2B","ribonuclease H2 subunit B",TRUE
+"229210_at",0.750020866111355,0.242835631581419,1.19994205112128,-5.26170578293559,0.815231724319179,"RNASEH2B","ribonuclease H2 subunit B",TRUE
+"233156_at",0.828426831961877,0.398300393859915,0.861296073968498,-5.58468330559471,0.414624642529357,"RNASEH2B","ribonuclease H2 subunit B",TRUE
+"215040_at",0.9116561917482,0.630701010241442,0.487488178921861,-5.82459367899714,0.170645770650831,"RNASEH2B","ribonuclease H2 subunit B",TRUE
+"226453_at",0.868313695469383,0.502643167973741,-0.681457677862263,-5.71599524426769,-0.236789245647071,"RNASEH2C","ribonuclease H2 subunit C",TRUE
+"227543_at",0.895213601869362,0.573409354090038,-0.571505670791524,-5.78183952313078,-0.194556418331741,"RNASEH2C","ribonuclease H2 subunit C",TRUE
+"224574_at",0.358427723880268,0.0100072919402318,2.81657134090594,-2.67445909067965,1.50798741964003,"RNASEK-C17orf49///C17orf49","RNASEK-C17orf49 readthrough///chromosome 17 open reading frame 49",TRUE
+"224573_at",0.759225918189959,0.256852342181247,1.16388190480687,-5.30059357742234,0.316657715880529,"RNASEK-C17orf49///RNASEK///C17orf49","RNASEK-C17orf49 readthrough///ribonuclease K///chromosome 17 open reading frame 49",TRUE
+"229285_at",0.861962516141708,0.484395047607681,-0.711176721174981,-5.69629795640593,-0.607981858819738,"RNASEL","ribonuclease L",TRUE
+"221287_at",0.933005936987066,0.7041802721103,0.384627731914771,-5.86788384860832,0.211518447512135,"RNASEL","ribonuclease L",TRUE
+"217983_s_at",0.700061364939874,0.171405398597638,-1.4134988132417,-5.01074830814118,-0.758255246517519,"RNASET2","ribonuclease T2",TRUE
+"217984_at",0.70171671295791,0.173250551590651,-1.40717070608615,-5.01867761211919,-0.707930766684628,"RNASET2","ribonuclease T2",TRUE
+"1568977_at",0.739340500562926,0.226663479169445,1.24354738288236,-5.21330756506001,0.388878773787604,"RNASET2","ribonuclease T2",TRUE
+"1556201_at",0.79476249846508,0.326902859222335,1.00254820227451,-5.46164469296848,0.400678110732859,"RNASET2","ribonuclease T2",TRUE
+"232722_at",0.95877806139143,0.813253549093893,-0.23906381624829,-5.91188536194416,-0.0863654422759765,"RNASET2","ribonuclease T2",TRUE
+"239388_at",0.961212424803935,0.824285402769275,-0.224682528741197,-5.91512531176968,-0.0714532506567602,"RNASET2","ribonuclease T2",TRUE
+"210056_at",0.776955214137673,0.295773662166914,-1.07082725343569,-5.39610123205178,-0.977156453204685,"RND1","Rho family GTPase 1",TRUE
+"213467_at",0.849935057946582,0.452161457864112,0.765311884467126,-5.65836630082406,0.67188225439816,"RND2","Rho family GTPase 2",TRUE
+"214393_at",0.966051687342135,0.841577853932658,0.202235736048142,-5.91978255364155,0.162720417275792,"RND2","Rho family GTPase 2",TRUE
+"212724_at",0.774230543658252,0.286486944669768,1.09218223784457,-5.37480786381662,0.912708124000364,"RND3","Rho family GTPase 3",TRUE
+"207801_s_at",0.90105641459739,0.597434137291787,-0.535801123214698,-5.80081510685805,-0.240034226091016,"RNF10","ring finger protein 10",TRUE
+"208632_at",0.975657122206595,0.883989072151263,-0.14760552921886,-5.92907721352511,-0.0540156088576182,"RNF10","ring finger protein 10",TRUE
+"202636_at",0.257126595624443,0.00378113547128171,-3.23495509219954,-1.82646286294871,-1.39171752500467,"RNF103","ring finger protein 103",TRUE
+"1568665_at",0.758722841981575,0.255910508470461,-1.16625831383993,-5.29806275488028,-0.561798938223908,"RNF103","ring finger protein 103",TRUE
+"217837_s_at",0.861665593344139,0.483618790370781,-0.712455099465798,-5.69543269263344,-0.261760491397645,"RNF103-CHMP3///CHMP3","RNF103-CHMP3 readthrough///charged multivesicular body protein 3",TRUE
+"222437_s_at",0.893172664248402,0.567527961421939,-0.580360087242435,-5.77695016600014,-0.200318812901802,"RNF103-CHMP3///CHMP3","RNF103-CHMP3 readthrough///charged multivesicular body protein 3",TRUE
+"222436_s_at",0.830635993561085,0.404229389810374,-0.850344545358084,-5.59350137740735,-0.262950018499067,"RNF103-CHMP3///CHMP3///RNF103","RNF103-CHMP3 readthrough///charged multivesicular body protein 3///ring finger protein 103",TRUE
+"208924_at",0.85334340854827,0.461382634511282,-0.7495974896363,-5.66964872251922,-0.218884596091053,"RNF11","ring finger protein 11",TRUE
+"218761_at",0.604395008363632,0.0786293862732604,-1.84379150493262,-4.4070299812576,-0.550906454667922,"RNF111","ring finger protein 111",TRUE
+"223603_at",0.888750194607196,0.555223098296743,0.599038775930907,-5.76639744288831,0.326942366438708,"RNF112","ring finger protein 112",TRUE
+"209565_at",0.637871005858186,0.109164316448378,-1.66911883791386,-4.66683915443047,-0.608588976286699,"RNF113A","ring finger protein 113A",TRUE
+"200867_at",0.429284714913652,0.0189230578634983,-2.53217558026117,-3.22226246327151,-1.08135579976686,"RNF114","ring finger protein 114",TRUE
+"211678_s_at",0.441216093529064,0.0203923743639313,-2.4980651662467,-3.28603612274228,-0.989233602556176,"RNF114","ring finger protein 114",TRUE
+"200868_s_at",0.617775129514679,0.0886077435515515,-1.78112307093257,-4.5024245153841,-0.848447842956039,"RNF114","ring finger protein 114",TRUE
+"226468_at",0.183361388083808,0.00173719614133356,-3.56020156914613,-1.14324126473991,-1.48869841300098,"RNF115","ring finger protein 115",TRUE
+"212742_at",0.527546822913581,0.0401078571340412,-2.18062428169377,-3.85615693594317,-0.815156726405926,"RNF115","ring finger protein 115",TRUE
+"243976_at",0.98539961718117,0.927767966360784,0.0916904071239739,-5.93558950675258,0.0280335947440928,"RNF115","ring finger protein 115",TRUE
+"219021_at",0.914910510855952,0.641595633356056,-0.471923883307398,-5.83178692749017,-0.156609891387228,"RNF121","ring finger protein 121",TRUE
+"219897_at",0.917166618334994,0.649942764104057,0.460078718723591,-5.83710822956066,0.255080844193217,"RNF122","ring finger protein 122",TRUE
+"224186_s_at",0.70190082585548,0.173423234238976,-1.40658123673339,-5.01941474271877,-0.493291615313479,"RNF123","ring finger protein 123",TRUE
+"221063_x_at",0.925091998149497,0.675581000377182,0.424101581944937,-5.85245693585499,0.140367517270583,"RNF123","ring finger protein 123",TRUE
+"207735_at",0.905462783815257,0.611685743513157,-0.514952220253842,-5.81134497119868,-0.295258857388847,"RNF125","ring finger protein 125",TRUE
+"235199_at",0.930827859648584,0.693673996179555,0.399053392061987,-5.86241802363501,0.317226747382062,"RNF125","ring finger protein 125",TRUE
+"215031_x_at",0.728385463227073,0.209762980173637,-1.29173060544194,-5.15810559809647,-0.418420310287701,"RNF126","ring finger protein 126",TRUE
+"205748_s_at",0.830592576740524,0.403208253738894,-0.852223322393117,-5.59199607486693,-0.373092463303522,"RNF126","ring finger protein 126",TRUE
+"223332_x_at",0.97580093550434,0.884333999396089,0.147163334658974,-5.92914063345614,0.0558497848406869,"RNF126","ring finger protein 126",TRUE
+"222349_x_at",0.934081042629428,0.708475840412941,0.378753718039004,-5.87005265813375,0.10992342206571,"RNF126P1","ring finger protein 126 pseudogene 1",TRUE
+"219263_at",0.845176959721596,0.442178915208712,0.782543666675283,-5.64574037752519,0.971515528053335,"RNF128","ring finger protein 128, E3 ubiquitin protein ligase",TRUE
+"201779_s_at",0.690823350461169,0.160384624500413,1.45247686929599,-4.96126562944027,0.475394329162249,"RNF13","ring finger protein 13",TRUE
+"201780_s_at",0.731054546207485,0.213773228123157,1.28003447231973,-5.17167011075681,0.424732429853188,"RNF13","ring finger protein 13",TRUE
+"1563975_at",0.330171916405281,0.00797429211383264,-2.91567054702944,-2.4775828113685,-1.48908699232079,"RNF130","ring finger protein 130",TRUE
+"217865_at",0.522667179791589,0.0384179794607898,-2.20136907774372,-3.82029366673356,-0.859651175782183,"RNF130","ring finger protein 130",TRUE
+"1559537_at",0.68622544935397,0.154941987604477,-1.47252886437282,-4.93538313014685,-1.26697832000575,"RNF130","ring finger protein 130",TRUE
+"236292_at",0.910967291330762,0.628627492989483,-0.490464215568682,-5.82319228103542,-0.135548674765784,"RNF130","ring finger protein 130",TRUE
+"222058_at",0.921980251030053,0.667164639263887,0.435846999278223,-5.8475808582284,0.199780137508053,"RNF130","ring finger protein 130",TRUE
+"230932_at",0.928224375663587,0.684466797505786,-0.411766488030808,-5.85743685028139,-0.338094331096308,"RNF130","ring finger protein 130",TRUE
+"231373_at",0.93146237901678,0.696991108373745,0.394489656129813,-5.86416864303072,0.165004809952228,"RNF133","ring finger protein 133",TRUE
+"223592_s_at",0.539609110035715,0.0443744026987038,-2.13157313832978,-3.94011456785382,-0.929473333088369,"RNF135","ring finger protein 135",TRUE
+"223591_at",0.585892284764425,0.0659064329880667,-1.93462127078287,-4.26463269222243,-0.742011762346026,"RNF135","ring finger protein 135",TRUE
+"239143_x_at",0.703902004301726,0.175425637316311,-1.39977982170289,-5.02790147816136,-0.601032282557598,"RNF138","ring finger protein 138",TRUE
+"218738_s_at",0.774230543658252,0.290300313347526,-1.08335396738864,-5.3836561562399,-0.472003547180375,"RNF138","ring finger protein 138",TRUE
+"209510_at",0.913300726876965,0.636573988369097,-0.479082990327489,-5.82850660055233,-0.300827287624058,"RNF139","ring finger protein 139",TRUE
+"227745_at",0.905462783815257,0.611756657231561,0.514849062800106,-5.81139605939561,0.186052750869115,"RNF139-AS1","RNF139 antisense RNA 1 (head to head)",TRUE
+"201824_at",0.40221114169538,0.0144716846835708,-2.65316980480241,-2.99256580100603,-0.999269289666577,"RNF14","ring finger protein 14",TRUE
+"201823_s_at",0.544819033181092,0.0467694056137532,-2.10587447086081,-3.98361958198375,-0.686432126400021,"RNF14","ring finger protein 14",TRUE
+"243345_at",0.739189560382301,0.226016009555753,-1.24534170318402,-5.21128411567931,-0.495620122631432,"RNF14","ring finger protein 14",TRUE
+"226106_at",0.765889357241662,0.266088645431547,-1.14091213094198,-5.32482208267629,-0.562361479179112,"RNF141","ring finger protein 141",TRUE
+"1565546_at",0.867099100798202,0.498992338500496,-0.687353536835877,-5.71215139095811,-0.584284731764768,"RNF141","ring finger protein 141",TRUE
+"1565544_at",0.8920930097751,0.563723016288409,0.586113431640954,-5.77373420555446,0.542394813628228,"RNF141","ring finger protein 141",TRUE
+"219104_at",0.967098323798013,0.846298538187978,-0.196126880922633,-5.92096557803216,-0.0626083044011274,"RNF141","ring finger protein 141",TRUE
+"204040_at",0.901430889731657,0.598217071843136,0.534649580268943,-5.80140731139362,0.623803112526931,"RNF144A","ring finger protein 144A",TRUE
+"1570051_at",0.914776697425609,0.640950072112922,0.472842819030593,-5.83136857157459,0.321533049286356,"RNF144A","ring finger protein 144A",TRUE
+"1556798_a_at",0.83872852514497,0.424051285998656,0.814456437937674,-5.62165905625966,0.324043771756091,"RNF144A-AS1","RNF144A antisense RNA 1",TRUE
+"1559145_at",0.982613314946763,0.915596789884998,0.107197821077343,-5.93408800620257,0.0738354862748123,"RNF144A-AS1","RNF144A antisense RNA 1",TRUE
+"1556797_at",0.986342822130003,0.934700907354591,0.0828676163783915,-5.93633935125639,0.0284006748093466,"RNF144A-AS1","RNF144A antisense RNA 1",TRUE
+"228153_at",0.930827859648584,0.693815879749726,0.398858010412208,-5.86249337708654,0.295427548003033,"RNF144B","ring finger protein 144B",TRUE
+"239704_at",0.931528703027792,0.697187299000324,-0.394220001787086,-5.86427146009023,-0.438373614720716,"RNF144B","ring finger protein 144B",TRUE
+"239012_at",0.934081042629428,0.708334048607172,0.378947394967113,-5.86998167326681,0.394182765475498,"RNF144B","ring finger protein 144B",TRUE
+"235549_at",0.98453870130544,0.924652765703652,0.0956571664584306,-5.93522769268057,0.0953021758602537,"RNF144B","ring finger protein 144B",TRUE
+"238949_at",0.826134344333512,0.393797666700769,0.86968341225827,-5.57785890004759,0.844705884928429,"RNF145","ring finger protein 145",TRUE
+"226077_at",0.859428001278279,0.476469713301275,0.724285083131881,-5.68735548788433,0.623834819396793,"RNF145","ring finger protein 145",TRUE
+"239899_at",0.961212424803935,0.824301192323543,0.224661980666694,-5.91512979798722,0.167060933611308,"RNF145","ring finger protein 145",TRUE
+"221430_s_at",0.824605880140909,0.392055415715829,-0.872945377637434,-5.57518818184971,-0.322712677271797,"RNF146","ring finger protein 146",TRUE
+"223886_s_at",0.879423777614825,0.533718148858073,-0.632212438427661,-5.74686081673547,-0.227599586429026,"RNF146","ring finger protein 146",TRUE
+"242925_at",0.816966928109267,0.36924254422112,-0.916559535287939,-5.53859026704473,-0.60476686076104,"RNF148","ring finger protein 148",TRUE
+"225414_at",0.587626678796111,0.066828609872595,1.92754247644487,-4.27590159153109,0.667715700027795,"RNF149","ring finger protein 149",TRUE
+"236038_at",0.699181208035307,0.170655202948901,-1.41608725800744,-5.00749647809942,-1.4941171140696,"RNF150","ring finger protein 150",TRUE
+"232501_at",0.741716158050666,0.232191825788021,-1.22838351105708,-5.23030743496494,-0.633807209003073,"RNF150","ring finger protein 150",TRUE
+"229024_at",0.868397087637799,0.503413738358992,-0.680216355310997,-5.71680050058035,-0.626398359555971,"RNF150","ring finger protein 150",TRUE
+"227657_at",0.969859842767097,0.855990431555371,-0.183608598734416,-5.92327687800078,-0.135223484979103,"RNF150","ring finger protein 150",TRUE
+"236689_at",0.98539961718117,0.928060348040702,0.0913181795408471,-5.93562267251889,0.0622651440250337,"RNF151","ring finger protein 151",TRUE
+"1553722_s_at",0.832792886465252,0.409800419549783,-0.840147464216318,-5.6016173525029,-0.476196754563252,"RNF152","ring finger protein 152",TRUE
+"1553721_at",0.986342822130003,0.9347305984423,0.0828298468009223,-5.93634239844673,0.0756435194096943,"RNF152","ring finger protein 152",TRUE
+"226433_at",0.580152731323135,0.0627651609192669,-1.95940773158554,-4.22495134323624,-1.57425066849605,"RNF157","ring finger protein 157",TRUE
+"1569775_at",0.910206474192635,0.626897946020522,0.492950004345151,-5.82201535080597,0.24600238703509,"RNF157","ring finger protein 157",TRUE
+"230776_at",0.882239639302705,0.539767684944029,0.622809536686177,-5.75250139332572,0.535762258211814,"RNF157-AS1","RNF157 antisense RNA 1",TRUE
+"1557545_s_at",0.677013732819214,0.144261515365168,1.51360319563314,-4.88147368922573,1.60172285873563,"RNF165","ring finger protein 165",TRUE
+"1569080_at",0.769017612409316,0.274384921497594,1.12077511804301,-5.3457122637392,0.731603546655727,"RNF165","ring finger protein 165",TRUE
+"230143_at",0.840041055449124,0.428967941431761,0.805718714016066,-5.62834243378521,0.325877746134965,"RNF165","ring finger protein 165",TRUE
+"227726_at",0.861405172272497,0.481995481366357,-0.715132297598373,-5.69361585188209,-0.270853973033841,"RNF166","ring finger protein 166",TRUE
+"212047_s_at",0.992816117752561,0.965918108833489,-0.0432138981812078,-5.93877396002346,-0.0145002721763809,"RNF167","ring finger protein 167",TRUE
+"226832_at",0.487608468788546,0.0288239702080399,2.33782281514768,-3.57935707041608,0.773980261749795,"RNF168","ring finger protein 168",TRUE
+"1553127_a_at",0.808429004235784,0.351435584319636,0.951862946833098,-5.50776321733136,0.786004344142744,"RNF168","ring finger protein 168",TRUE
+"226739_at",0.92098757163064,0.663700618378031,0.440699262553264,-5.84552827947835,0.1901858567717,"RNF169","ring finger protein 169",TRUE
+"221033_s_at",0.522688200326889,0.0386076971106073,2.19899931697614,-3.82440101494905,1.44680261900731,"RNF17","ring finger protein 17",TRUE
+"224383_at",0.609303182105525,0.0815970351966466,1.82446610180251,-4.43670067461062,1.38169689856736,"RNF17","ring finger protein 17",TRUE
+"1563114_at",0.683940813329598,0.152925037822667,1.48010496555103,-4.92552941663967,0.932797473019275,"RNF17","ring finger protein 17",TRUE
+"224384_s_at",0.771179671695472,0.280417431238732,-1.10641040678303,-5.36041297262204,-0.891992316814267,"RNF17","ring finger protein 17",TRUE
+"220270_at",0.869082033398093,0.505852038663476,0.676295509303179,-5.71933476350529,0.556940752500461,"RNF17","ring finger protein 17",TRUE
+"220985_s_at",0.663686946815633,0.131584206739487,-1.56572687705386,-4.81136432436618,-0.757892692665301,"RNF170","ring finger protein 170",TRUE
+"226104_at",0.797508506396963,0.331022754142488,-0.993857795164103,-5.46970673151702,-0.53341657002044,"RNF170","ring finger protein 170",TRUE
+"1554312_at",0.9116561917482,0.63055375852762,0.487699375917016,-5.82449450235524,0.140032300987235,"RNF170","ring finger protein 170",TRUE
+"236465_at",0.886783047600321,0.550088578973884,0.606896571381688,-5.7618616071106,0.422768055920912,"RNF175","ring finger protein 175",TRUE
+"242033_at",0.869784729509912,0.507520801630935,0.673618224877301,-5.72105718932436,0.835395902934681,"RNF180","ring finger protein 180",TRUE
+"236644_at",0.954449231029359,0.790777695965833,-0.268527488408157,-5.90462371192958,-0.372818396093246,"RNF180","ring finger protein 180",TRUE
+"242985_x_at",0.998965910333026,0.99662722470847,0.00427511006891215,-5.93967457891153,0.00306554398940584,"RNF180","ring finger protein 180",TRUE
+"223064_at",0.724853010944214,0.20240565670424,-1.31364680113098,-5.13240670130599,-0.494732889956998,"RNF181","ring finger protein 181",TRUE
+"230720_at",0.327864702134751,0.0076382228088173,2.93434577221062,-2.44017578747807,4.28613960506895,"RNF182","ring finger protein 182",TRUE
+"235153_at",0.5932897315606,0.0699090437480425,-1.90450311673478,-4.31238036045103,-1.37803961673838,"RNF183","ring finger protein 183",TRUE
+"224750_at",0.841550580403629,0.432791087812315,-0.798967279402996,-5.63346015206629,-0.250091051833534,"RNF185","ring finger protein 185",TRUE
+"207280_at",0.398650588126476,0.0139816320537815,2.66857001966685,-2.96295765515489,1.59361663883164,"RNF185-AS1","RNF185 antisense RNA 1",TRUE
+"219739_at",0.913627134030439,0.6378855080619,-0.477210785740077,-5.8293691166967,-0.291564930155708,"RNF186","ring finger protein 186",TRUE
+"212155_at",0.17741356959532,0.00159647876069314,-3.59519477890848,-1.06886101653296,-1.64245164599327,"RNF187","ring finger protein 187",TRUE
+"229207_x_at",0.64513208805899,0.116186197559425,-1.63496083681131,-4.7153742136163,-1.09624267952637,"RNF187","ring finger protein 187",TRUE
+"1569294_at",0.771158062322823,0.280111071215797,1.10713447000486,-5.35967599885462,0.532911665277049,"RNF187","ring finger protein 187",TRUE
+"230662_at",0.885029460971826,0.545339240838134,-0.614199338244566,-5.757595023709,-0.33464495785825,"RNF187","ring finger protein 187",TRUE
+"228470_at",0.932018790587499,0.699357252007666,-0.39123948644868,-5.86540329297272,-0.208964932625722,"RNF187","ring finger protein 187",TRUE
+"220483_s_at",0.932091525948902,0.700115626180715,0.390198681363734,-5.86579653867192,0.259067700887605,"RNF19A","ring finger protein 19A, RBR E3 ubiquitin protein ligase",TRUE
+"223085_at",0.951934441578502,0.780114930294734,-0.282589096787482,-5.90086295034958,-0.130547990097313,"RNF19A","ring finger protein 19A, RBR E3 ubiquitin protein ligase",TRUE
+"213038_at",0.580630437263151,0.0630810838576952,1.95686601808767,-4.22903633351519,0.785594181765683,"RNF19B","ring finger protein 19B",TRUE
+"36564_at",0.687545925823023,0.156413647835084,1.46705134174844,-4.94248189682806,0.515444463900106,"RNF19B","ring finger protein 19B",TRUE
+"205215_at",0.895457620469779,0.574471006654136,0.569912281989112,-5.78271165157776,0.460816171400145,"RNF2","ring finger protein 2",TRUE
+"222683_at",0.983498417373669,0.919371484781881,-0.102385746335126,-5.93457896484946,-0.0278974481107337,"RNF20","ring finger protein 20",TRUE
+"233065_at",0.547024587451534,0.0475038452898013,2.09823092366046,-3.99649424254383,0.66309604927577,"RNF207","ring finger protein 207",TRUE
+"1555870_at",0.54756909892274,0.0480015040163888,2.09311173655581,-4.00510011082744,0.979820925356368,"RNF207","ring finger protein 207",TRUE
+"244759_x_at",0.574698486578065,0.0606179455344436,1.97698877656556,-4.19659682712127,0.976889537474509,"RNF207","ring finger protein 207",TRUE
+"242882_at",0.629618998226163,0.100523224185259,1.71380169112772,-4.60220322569461,1.30860164959692,"RNF207","ring finger protein 207",TRUE
+"1568728_s_at",0.850525739652024,0.453224827156136,0.763489954010958,-5.6596857304421,0.467566970018517,"RNF207","ring finger protein 207",TRUE
+"244591_x_at",0.956960361976289,0.805094918998568,0.249732607382511,-5.90935268869319,0.0863836282616792,"RNF207","ring finger protein 207",TRUE
+"221273_s_at",0.784918343662568,0.309692894572453,-1.03969940818364,-5.42646416971972,-0.632897412114779,"RNF208","ring finger protein 208",TRUE
+"1557031_at",0.896115372949367,0.577663485030397,0.565129771704658,-5.78531514618132,0.380814679919792,"RNF212","ring finger protein 212",TRUE
+"236454_at",0.940044918888428,0.731594903642657,-0.34736523318967,-5.88108345303389,-0.274466338594736,"RNF212","ring finger protein 212",TRUE
+"240320_at",0.906222238025079,0.61280877972451,-0.513319214853465,-5.81215253753247,-0.351048566742798,"RNF212B","ring finger protein 212B",TRUE
+"241347_at",0.662575055303091,0.13040917663527,1.5707653705137,-4.80448804729947,0.70137105384984,"RNF213","ring finger protein 213",TRUE
+"241480_at",0.687545925823023,0.156560526319097,-1.46650695602159,-4.94318624051301,-0.470109964355588,"RNF213","ring finger protein 213",TRUE
+"232155_at",0.701198950693331,0.172866221424699,-1.40848434178789,-5.01703399729074,-1.35620415994496,"RNF213","ring finger protein 213",TRUE
+"231956_at",0.758722841981575,0.25584078114282,1.16643450589032,-5.29787493419045,0.660510396681714,"RNF213","ring finger protein 213",TRUE
+"230000_at",0.7994347047598,0.334456004560923,0.986672735518777,-5.47632409570552,0.468856068561891,"RNF213","ring finger protein 213",TRUE
+"233880_at",0.936318756756998,0.715863756638975,-0.368682562483209,-5.87369451844609,-0.30418173651142,"RNF213","ring finger protein 213",TRUE
+"225929_s_at",0.947543670578546,0.76091179516089,0.308063066102873,-5.89356521699158,0.156023180278295,"RNF213","ring finger protein 213",TRUE
+"225931_s_at",0.998347572104896,0.993042077607989,-0.00881950021404705,-5.93964559530418,-0.00387162756418213,"RNF213","ring finger protein 213",TRUE
+"227114_at",0.911165621741659,0.629125073367524,0.489749649623297,-5.82352952621458,0.130995873614033,"RNF214","ring finger protein 214",TRUE
+"234461_at",0.716156128190082,0.191839895773603,1.34623329205982,-5.09352220022822,0.850164608604534,"RNF215","ring finger protein 215",TRUE
+"1563361_at",0.867924381823852,0.501216053107938,-0.683759481165973,-5.71449833084891,-0.261958723291716,"RNF216","ring finger protein 216",TRUE
+"218425_at",0.877510999184545,0.527711078433382,0.641606463017201,-5.74114438466118,0.215843061412672,"RNF216","ring finger protein 216",TRUE
+"218426_s_at",0.950961978103462,0.776127596687897,0.287862254721394,-5.8994035498449,0.109641616758465,"RNF216","ring finger protein 216",TRUE
+"227065_at",0.956734254923335,0.803418522048457,-0.251928412798416,-5.90881778671995,-0.0673816144174051,"RNF216","ring finger protein 216",TRUE
+"235492_at",0.606900628956089,0.0807356570384011,1.83001172107115,-4.42820928577518,1.15264916775578,"RNF217","ring finger protein 217",TRUE
+"226885_at",0.734826592415085,0.21975582281809,1.26289622874441,-5.1913558896961,1.41974910219254,"RNF217","ring finger protein 217",TRUE
+"232100_at",0.83030603167465,0.402474895063095,0.853574501259513,-5.59091157716611,0.837407778210258,"RNF217","ring finger protein 217",TRUE
+"1563496_at",0.986844665519238,0.938473296870257,-0.0780697870873421,-5.9367153196984,-0.0739933180117567,"RNF217-AS1","RNF217 antisense RNA 1 (head to head)",TRUE
+"219303_at",0.54751541861133,0.0479770712495086,2.0933619504634,-4.00467979022514,0.677055258762694,"RNF219","ring finger protein 219",TRUE
+"237686_at",0.864894115958506,0.492996451527657,-0.697089979370262,-5.70573441201048,-0.362875226001511,"RNF219","ring finger protein 219",TRUE
+"219988_s_at",0.885312914741353,0.546718833473152,0.612074569185655,-5.75884148045741,0.2022827371694,"RNF220","ring finger protein 220",TRUE
+"204669_s_at",0.896139457361073,0.578632687287347,0.563680489072053,-5.78609990426312,0.706633562612291,"RNF24","ring finger protein 24",TRUE
+"210706_s_at",0.933609099853387,0.70621354614505,0.3818456081441,-5.86891516965112,0.178798920013447,"RNF24","ring finger protein 24",TRUE
+"204668_at",0.936143408699214,0.715304310658017,-0.369443824326444,-5.87342261978178,-0.18398173368459,"RNF24","ring finger protein 24",TRUE
+"226542_at",0.977874971442423,0.89319130177404,0.135818354966661,-5.93070280152329,0.0652247162393618,"RNF24","ring finger protein 24",TRUE
+"218861_at",0.837368340567858,0.421072861394982,-0.819780412992721,-5.61755367015416,-0.459710169416518,"RNF25","ring finger protein 25",TRUE
+"224947_at",0.801547748171611,0.33838169588537,0.978519093162371,-5.48378057540971,0.899069777705382,"RNF26","ring finger protein 26",TRUE
+"224338_s_at",0.8363408317442,0.417966178699392,0.825358883090817,-5.61322515592237,0.370304027900556,"RNF26","ring finger protein 26",TRUE
+"231635_x_at",0.581406183553129,0.063919211565189,1.95017703717194,-4.23976942765214,0.931197149743417,"RNF31","ring finger protein 31",TRUE
+"225122_at",0.911143250035311,0.629092961844225,0.489795756578183,-5.8235077801639,0.195434745069953,"RNF31","ring finger protein 31",TRUE
+"220788_s_at",0.681732274610686,0.149379742197223,-1.49362112105751,-4.90784871330259,-0.428455160730962,"RNF31///IRF9","ring finger protein 31///interferon regulatory factor 9",TRUE
+"232830_at",0.812302873476553,0.358194040184789,0.93832548795579,-5.51971065747056,0.69327234657512,"RNF32","ring finger protein 32",TRUE
+"1554642_at",0.975398143273847,0.882476325224509,0.149545218448968,-5.92879677843531,0.0582432920492373,"RNF32","ring finger protein 32",TRUE
+"220991_s_at",0.987878312181854,0.942062844320029,0.0735062458538906,-5.93705213936664,0.0575957652640895,"RNF32","ring finger protein 32",TRUE
+"236288_at",0.73957587762701,0.228100225598671,1.23957966239122,-5.21777303851995,0.623126985443534,"RNF34","ring finger protein 34",TRUE
+"219035_s_at",0.819723837900625,0.377139772919599,-0.90126594360026,-5.55161140291891,-0.278867805539699,"RNF34","ring finger protein 34",TRUE
+"229855_at",0.864829185767069,0.492676071769975,0.697612128073268,-5.70538784677585,0.293661676936947,"RNF34","ring finger protein 34",TRUE
+"222660_s_at",0.80861715520522,0.35181316667621,0.951102018609525,-5.50843893248873,0.267575264986521,"RNF38","ring finger protein 38",TRUE
+"218528_s_at",0.998709719538178,0.994312559014299,-0.00720907170716911,-5.93965816776172,-0.00226037777323285,"RNF38","ring finger protein 38",TRUE
+"219916_s_at",0.809951984800123,0.353741992593363,0.947223520149445,-5.51187540053712,0.354207146655884,"RNF39","ring finger protein 39",TRUE
+"212696_s_at",0.467673691528294,0.0245747876682357,-2.41218813159538,-3.44455763270799,-0.695459838934886,"RNF4","ring finger protein 4",TRUE
+"206845_s_at",0.518874125067442,0.0372946550533498,-2.21562224427569,-3.79553267078194,-0.580963707632204,"RNF40","ring finger protein 40",TRUE
+"239801_at",0.711989638658417,0.186044132738488,-1.36471097194953,-5.07111877201412,-0.560532097954696,"RNF40","ring finger protein 40",TRUE
+"217642_at",0.95599181039166,0.801232166792637,0.254794085138629,-5.90811270402704,0.120179385196311,"RNF40","ring finger protein 40",TRUE
+"201962_s_at",0.21219412234776,0.00249015050576426,-3.41037633739219,-1.45996285762668,-1.21745590772169,"RNF41","ring finger protein 41",TRUE
+"235459_at",0.517859245504688,0.0369320365291373,-2.22030666622535,-3.78737354555417,-0.815857627660595,"RNF41","ring finger protein 41",TRUE
+"201961_s_at",0.796466121438385,0.329126424366735,-0.99784850529294,-5.46601248589706,-0.401112565819279,"RNF41","ring finger protein 41",TRUE
+"218704_at",0.931528703027792,0.697293146739679,0.394074531643786,-5.8643268979412,0.386433198281972,"RNF43","ring finger protein 43",TRUE
+"203286_at",0.845487921422997,0.442632868952402,0.781754942809884,-5.64632407460897,0.303324362976054,"RNF44","ring finger protein 44",TRUE
+"216018_at",0.675447258877226,0.141655848692903,1.52399980515841,-4.86764012928168,1.11006034541699,"RNF5","ring finger protein 5",TRUE
+"209111_at",0.895690630367785,0.575310751704449,0.568652999678462,-5.78339924008788,0.201795010425048,"RNF5P1///RNF5","ring finger protein 5 pseudogene 1///ring finger protein 5",TRUE
+"210931_at",0.679481244316939,0.146770434300559,-1.5037369674019,-4.8945315522511,-1.13248452837438,"RNF6","ring finger protein 6",TRUE
+"210932_s_at",0.822173415758858,0.386438018522424,0.883527205055686,-5.56646048090763,0.285829120787754,"RNF6","ring finger protein 6",TRUE
+"203403_s_at",0.899046682581382,0.58918309429074,0.547981868137536,-5.79447506861547,0.169888827965863,"RNF6","ring finger protein 6",TRUE
+"218286_s_at",0.851319596585235,0.455383401728673,-0.759799458507271,-5.66234925198598,-0.248798259120687,"RNF7","ring finger protein 7",TRUE
+"224394_at",0.934200936091995,0.70876248797498,0.378362224103182,-5.87019603596257,0.189340810078092,"RNF7","ring finger protein 7",TRUE
+"224439_x_at",0.942684843065067,0.743143531119945,-0.331819998460119,-5.88619746097956,-0.0972846763363826,"RNF7","ring finger protein 7",TRUE
+"224395_s_at",0.965870429614853,0.840108534993396,-0.204138721557273,-5.91940664381954,-0.0625627438935101,"RNF7","ring finger protein 7",TRUE
+"203160_s_at",0.634743115037769,0.105692292479423,1.68669898611956,-4.64156233066542,0.636295212810296,"RNF8","ring finger protein 8",TRUE
+"203161_s_at",0.634921787904982,0.105791266352344,1.6861911198206,-4.64229535320333,0.73031813353335,"RNF8","ring finger protein 8",TRUE
+"221195_at",0.921312278448293,0.664979358836854,0.438906807772515,-5.84628911234992,0.199628179542041,"RNFT1","ring finger protein, transmembrane 1",TRUE
+"227268_at",0.937203701144735,0.721274025363844,-0.361331942410362,-5.87629144364189,-0.21874237373633,"RNFT1","ring finger protein, transmembrane 1",TRUE
+"1553209_at",0.353309890338186,0.00941155901239277,2.84345861718597,-2.62132112495265,0.815413916971277,"RNFT2","ring finger protein, transmembrane 2",TRUE
+"221908_at",0.661974206478491,0.129536872392131,1.57453018247911,-4.79933871247722,1.10931624874665,"RNFT2","ring finger protein, transmembrane 2",TRUE
+"221909_at",0.749302175796142,0.242366876615542,1.20117462729503,-5.26035829033014,1.10425085529902,"RNFT2","ring finger protein, transmembrane 2",TRUE
+"211387_x_at",0.536422380101288,0.0432962431591842,2.14355220124924,-3.91972126443081,0.67966447397334,"RNGTT","RNA guanylyltransferase and 5'-phosphatase",TRUE
+"204207_s_at",0.697464915010884,0.168034618584302,1.42520134480345,-4.99600769312689,0.467678797855813,"RNGTT","RNA guanylyltransferase and 5'-phosphatase",TRUE
+"204208_at",0.769393110223875,0.276784510013597,1.11503389891404,-5.35160793532894,0.434729149537514,"RNGTT","RNA guanylyltransferase and 5'-phosphatase",TRUE
+"211849_s_at",0.940724219066753,0.734722917936082,0.343146252551385,-5.88249428306197,0.100633549825497,"RNGTT","RNA guanylyltransferase and 5'-phosphatase",TRUE
+"206050_s_at",0.79510118595964,0.327236090676103,-1.00184247930991,-5.46230176424695,-0.377134850978523,"RNH1","ribonuclease/angiogenin inhibitor 1",TRUE
+"1555529_at",0.8552783609358,0.467625649727749,0.739064710478079,-5.67708680086023,0.249374291592258,"RNH1","ribonuclease/angiogenin inhibitor 1",TRUE
+"220564_at",0.851319596585235,0.454898126007565,0.760628210317179,-5.66175218381756,0.471456045945706,"RNLS","renalase, FAD dependent amine oxidase",TRUE
+"223824_at",0.860714927752408,0.480532123539604,-0.717550195929202,-5.69196940776842,-0.476783685836033,"RNLS","renalase, FAD dependent amine oxidase",TRUE
+"202684_s_at",0.528056136690037,0.0405564308523171,2.17525080220171,-3.86541236095259,1.10988217239991,"RNMT","RNA guanine-7 methyltransferase",TRUE
+"202683_s_at",0.657015752622694,0.125419059743292,1.59259197677817,-4.77450061301972,0.694745861035608,"RNMT","RNA guanine-7 methyltransferase",TRUE
+"226975_at",0.900867933475689,0.596727669175667,-0.536840828555504,-5.80027935252363,-0.188532841308122,"RNPC3","RNA binding region (RNP1, RRM) containing 3",TRUE
+"226999_at",0.937836182672692,0.724693934736874,0.356695976621202,-5.87790274222749,0.30711865984019,"RNPC3","RNA binding region (RNP1, RRM) containing 3",TRUE
+"229903_x_at",0.998347572104896,0.992372113113525,0.00966873877361004,-5.93963794799384,0.00339691260092678,"RNPC3","RNA binding region (RNP1, RRM) containing 3",TRUE
+"208270_s_at",0.73223722457785,0.216174354881607,-1.27311222551391,-5.1796486018419,-0.537037276409349,"RNPEP","arginyl aminopeptidase",TRUE
+"218301_at",0.954614142466984,0.793085373307504,-0.265491585967644,-5.90541064839587,-0.08783224584751,"RNPEPL1","arginyl aminopeptidase like 1",TRUE
+"207939_x_at",0.621733119678766,0.0920563422524837,-1.76087817029049,-4.53272808718952,-0.56479229033496,"RNPS1","RNA binding protein with serine rich domain 1",TRUE
+"200060_s_at",0.884986112364738,0.545115610330656,-0.614544029359995,-5.75739242435182,-0.146439040327287,"RNPS1","RNA binding protein with serine rich domain 1",TRUE
+"1570093_at",0.895690630367785,0.575545103438108,-0.568301731454431,-5.78359077525981,-0.424309732861063,"RNU6-501P","RNA, U6 small nuclear 501, pseudogene",TRUE
+"213194_at",0.928576500287959,0.685981808910933,0.409669899720499,-5.85826890866431,0.507462933364044,"ROBO1","roundabout guidance receptor 1",TRUE
+"240425_x_at",0.682744111897512,0.150661696858186,-1.48870391530339,-4.91429596078361,-1.49698902547944,"ROBO2","roundabout guidance receptor 2",TRUE
+"226709_at",0.789661545166663,0.317245730977984,-1.02322149836022,-5.44221073166361,-1.05831608405923,"ROBO2","roundabout guidance receptor 2",TRUE
+"226766_at",0.791838559691106,0.322618981167695,-1.01166552474516,-5.45311820417063,-1.19536602669545,"ROBO2","roundabout guidance receptor 2",TRUE
+"219550_at",0.180622515496298,0.00166815099900037,3.57700918217665,-1.1075330890261,3.17916189351901,"ROBO3","roundabout guidance receptor 3",TRUE
+"226028_at",0.250373992456606,0.00353523040103337,3.26333337629637,-1.76753645495936,3.06891020975703,"ROBO4","roundabout guidance receptor 4",TRUE
+"220758_s_at",0.740476003158683,0.22933916231147,1.2361734633305,-5.22159674510526,0.352320260269492,"ROBO4","roundabout guidance receptor 4",TRUE
+"1561486_at",0.848364007856994,0.448330931855287,-0.771896507950666,-5.65357299511522,-0.580178767783642,"ROCK1","Rho associated coiled-coil containing protein kinase 1",TRUE
+"214578_s_at",0.893172664248402,0.567535278078003,-0.580349043034607,-5.77695630988105,-0.231754206467864,"ROCK1","Rho associated coiled-coil containing protein kinase 1",TRUE
+"235854_x_at",0.979588787486838,0.902489752623534,0.123927907226065,-5.93220587111134,0.0867556280045436,"ROCK1","Rho associated coiled-coil containing protein kinase 1",TRUE
+"230239_at",0.985498770484702,0.93004657435836,-0.088789885914292,-5.93584437786475,-0.0265109745044736,"ROCK1","Rho associated coiled-coil containing protein kinase 1",TRUE
+"213044_at",0.990173057239577,0.951290541393334,-0.061781788112635,-5.93782453696669,-0.0201324381535386,"ROCK1","Rho associated coiled-coil containing protein kinase 1",TRUE
+"202762_at",0.768852835478002,0.273110253459902,1.12383978388836,-5.34255418118805,0.599231178841725,"ROCK2","Rho associated coiled-coil containing protein kinase 2",TRUE
+"211504_x_at",0.784925710185113,0.310078012974676,1.03885239451191,-5.42727911703794,0.412171616474193,"ROCK2","Rho associated coiled-coil containing protein kinase 2",TRUE
+"218394_at",0.94118897722809,0.736677317565813,-0.340513435874868,-5.88336606111577,-0.177460762868416,"ROGDI","rogdi homolog",TRUE
+"205806_at",0.519956259865057,0.0376217706564265,-2.21143185614929,-3.80282243415195,-1.42809954172843,"ROM1","retinal outer segment membrane protein 1",TRUE
+"224972_at",0.805335305758344,0.344682438246279,-0.965567016234223,-5.49550918825274,-0.348408413460342,"ROMO1","reactive oxygen species modulator 1",TRUE
+"224191_x_at",0.825648186672984,0.393285104795609,0.870642094819323,-5.57707494733307,0.771894669871195,"ROPN1","rhophilin associated tail protein 1",TRUE
+"231535_x_at",0.849619613504567,0.450825087181498,0.767605238445943,-5.6567012455436,0.558661845337955,"ROPN1","rhophilin associated tail protein 1",TRUE
+"233203_at",0.996933548096082,0.984479856036646,0.0196735863136928,-5.93949496472359,0.0140182678173995,"ROPN1","rhophilin associated tail protein 1",TRUE
+"220425_x_at",0.961539013416204,0.825718879888754,-0.222817444539301,-5.91553084816381,-0.224793386083046,"ROPN1B","rhophilin associated tail protein 1B",TRUE
+"233312_at",0.755049574909504,0.248898203616612,1.18415928301459,-5.27885356238023,0.776886512428824,"ROPN1L","rhophilin associated tail protein 1 like",TRUE
+"223609_at",0.94895689004559,0.769249882606656,0.296977594375979,-5.89681767237562,0.239740897688407,"ROPN1L","rhophilin associated tail protein 1 like",TRUE
+"232060_at",0.487765518929235,0.0288686503075518,2.3370960196022,-3.58066273389638,3.482071810535,"ROR1","receptor tyrosine kinase like orphan receptor 1",TRUE
+"205805_s_at",0.519082612629108,0.0373302758638803,2.21516432004191,-3.79632970207197,2.94590176919886,"ROR1","receptor tyrosine kinase like orphan receptor 1",TRUE
+"211057_at",0.580630437263151,0.063043454219621,1.95716817149751,-4.22855090804452,2.12286551926407,"ROR1","receptor tyrosine kinase like orphan receptor 1",TRUE
+"1562823_at",0.934926171367715,0.711009723784046,0.375295102357276,-5.871314254382,0.32895463978014,"ROR1-AS1","ROR1 antisense RNA 1",TRUE
+"205578_at",0.825433910888158,0.392902012452937,-0.87135914922364,-5.57648805891604,-1.11156019637665,"ROR2","receptor tyrosine kinase like orphan receptor 2",TRUE
+"210479_s_at",0.56861088242915,0.0585576655045641,-1.99438419833905,-4.16837329997274,-0.856198040352283,"RORA","RAR related orphan receptor A",TRUE
+"235567_at",0.818598668505758,0.371987261203026,-0.911219840273142,-5.54315951748579,-0.883361844217812,"RORA","RAR related orphan receptor A",TRUE
+"241760_x_at",0.894913109111832,0.57226935160837,0.573218317327156,-5.78089948925858,0.579994392079793,"RORA","RAR related orphan receptor A",TRUE
+"226682_at",0.907189812622248,0.616117850467556,-0.508515687386151,-5.81451351593027,-0.47679398983774,"RORA","RAR related orphan receptor A",TRUE
+"240951_at",0.919425567954538,0.657698278706355,-0.44913270674425,-5.84190775436533,-0.332371074310823,"RORA","RAR related orphan receptor A",TRUE
+"239550_at",0.935318317015903,0.712369236427277,0.373441362793805,-5.87198574182329,0.204195501220914,"RORA","RAR related orphan receptor A",TRUE
+"210426_x_at",0.939976205834042,0.730291674876576,-0.349124886723367,-5.88048998779978,-0.287439796652232,"RORA","RAR related orphan receptor A",TRUE
+"236266_at",0.974536463688956,0.875541774676315,-0.158444549051759,-5.92746331130196,-0.157489232048019,"RORA","RAR related orphan receptor A",TRUE
+"1562682_at",0.904381089098038,0.607206356296821,0.521479881521073,-5.80809189762124,0.367561176689124,"RORA-AS1","RORA antisense RNA 1",TRUE
+"240163_at",0.97689149311934,0.88994400182527,-0.139975497576321,-5.93014488813245,-0.0818889689719988,"RORA-AS1","RORA antisense RNA 1",TRUE
+"206443_at",0.943030329412475,0.744420466711338,0.33010633558278,-5.88674704325129,0.237044910061295,"RORB","RAR related orphan receptor B",TRUE
+"231040_at",0.992511588832933,0.965077476237959,-0.0442804920316439,-5.93872851100856,-0.0400794261876509,"RORB","RAR related orphan receptor B",TRUE
+"242385_at",0.997753425334788,0.988921003608916,-0.0140434512370809,-5.9395874233346,-0.0138619837775407,"RORB","RAR related orphan receptor B",TRUE
+"206419_at",0.741877580525799,0.23246175966288,-1.22765015498168,-5.23112502322294,-0.769471220968495,"RORC","RAR related orphan receptor C",TRUE
+"228806_at",0.7717895132349,0.281746837509274,-1.10327507022271,-5.36359927313577,-1.09733683940867,"RORC","RAR related orphan receptor C",TRUE
+"207569_at",0.702481283743782,0.173876163016088,1.40503734334105,-5.02134417288983,0.657343271297709,"ROS1","ROS proto-oncogene 1, receptor tyrosine kinase",TRUE
+"244363_at",0.99709957716848,0.985318574391144,0.0186102813649273,-5.93951479145949,0.0141115132212644,"ROS1","ROS proto-oncogene 1, receptor tyrosine kinase",TRUE
+"224021_at",0.429276772897071,0.018810978334878,2.53487801391639,-3.21719088102964,1.45336399004874,"RP1","retinitis pigmentosa 1 (autosomal dominant)",TRUE
+"1555245_s_at",0.766550448794594,0.267678225729879,1.13701853578602,-5.32888690678497,0.499056801765386,"RP1L1","retinitis pigmentosa 1-like 1",TRUE
+"1568782_at",0.591331966259927,0.0685726211212059,1.91438680499358,-4.29676854783501,1.05921457264493,"RP2","retinitis pigmentosa 2 (X-linked recessive)",TRUE
+"205191_at",0.956734254923335,0.803608360171052,-0.251679692588924,-5.90887860912461,-0.124692745830517,"RP2","retinitis pigmentosa 2 (X-linked recessive)",TRUE
+"227849_at",0.822850703882235,0.388500702886309,0.879630048475735,-5.56968613628808,0.241030679314789,"RP9","retinitis pigmentosa 9 (autosomal dominant)",TRUE
+"227852_at",0.82653395242931,0.394740541659729,-0.867921989633997,-5.5792971926398,-0.304104642974076,"RP9","retinitis pigmentosa 9 (autosomal dominant)",TRUE
+"223945_x_at",0.937203701144735,0.721145027414555,-0.361506967011534,-5.8762302087262,-0.109755491889855,"RP9P","retinitis pigmentosa 9 pseudogene",TRUE
+"227035_x_at",0.942303845415102,0.740632999873421,0.335192123992238,-5.88510777872329,0.0850570886350521,"RP9P","retinitis pigmentosa 9 pseudogene",TRUE
+"1560340_s_at",0.982243328340126,0.914424345037064,0.108693005357855,-5.93393087215248,0.0823341183448463,"RP9P","retinitis pigmentosa 9 pseudogene",TRUE
+"227640_s_at",0.939166148226364,0.727646619030849,0.352699774484638,-5.87927518633311,0.0934097489709149,"RP9P///RP9","retinitis pigmentosa 9 pseudogene///retinitis pigmentosa 9 (autosomal dominant)",TRUE
+"236675_at",0.620912785033482,0.0905029188440725,1.76991535195132,-4.51923216374053,0.768962323411867,"RPA1","replication protein A1",TRUE
+"201528_at",0.804772751556177,0.343811283600351,0.967348105622519,-5.49390480176958,0.32169360143774,"RPA1","replication protein A1",TRUE
+"201529_s_at",0.8289434059415,0.399911654249576,0.858309593339852,-5.58709841448757,0.29703174649787,"RPA1","replication protein A1",TRUE
+"201756_at",0.854688049545347,0.466463491512266,-0.741019064338947,-5.67571420757635,-0.222447783339724,"RPA2","replication protein A2",TRUE
+"209507_at",0.976371465776674,0.887332816881155,0.143320125348212,-5.92968383281192,0.0461574883686247,"RPA3","replication protein A3",TRUE
+"221143_at",0.962125056232529,0.828005435846592,0.219844096225617,-5.91617040393327,0.185170320852962,"RPA4","replication protein A4",TRUE
+"216962_at",0.374729827016997,0.0113909642890215,2.75956829902365,-2.78639692315544,2.21272674433012,"RPAIN","RPA interacting protein",TRUE
+"216961_s_at",0.513365264670114,0.0344762415279288,2.25318053868301,-3.72982330351467,1.07273536886553,"RPAIN","RPA interacting protein",TRUE
+"1564301_a_at",0.556381379241158,0.0516915089260655,2.05657311030041,-4.06612975218137,0.847330063090813,"RPAIN","RPA interacting protein",TRUE
+"228288_at",0.597346378847428,0.0733968035474851,1.87946801374332,-4.3516718368251,0.62887062528547,"RPAIN","RPA interacting protein",TRUE
+"228183_s_at",0.62986301194198,0.101072420303683,1.71086659279535,-4.60648836458328,0.781349023871892,"RPAIN","RPA interacting protein",TRUE
+"1558719_s_at",0.67747053724365,0.14481914877194,1.51139825613153,-4.88439783058162,0.481325803664465,"RPAIN","RPA interacting protein",TRUE
+"1556088_at",0.84113463994907,0.430986463058202,0.802149504943968,-5.63105300469214,0.326682969700305,"RPAIN","RPA interacting protein",TRUE
+"218441_s_at",0.84099217690599,0.430717200507024,-0.802625022461499,-5.63069253432824,-0.247970202735026,"RPAP1","RNA polymerase II associated protein 1",TRUE
+"219504_s_at",0.935351255251442,0.712592125745315,0.373137573283339,-5.87209547185339,0.11731008856695,"RPAP2","RNA polymerase II associated protein 2",TRUE
+"222893_s_at",0.957174671135192,0.806141019722076,0.248363023081051,-5.90968396479875,0.0874238701007446,"RPAP2","RNA polymerase II associated protein 2",TRUE
+"1557984_s_at",0.860085676417428,0.479508579580357,-0.719243941525493,-5.69081291926006,-0.218544026419558,"RPAP3","RNA polymerase II associated protein 3",TRUE
+"218842_at",0.95442332217412,0.79033466030366,-0.269110625402387,-5.90447153965079,-0.0714010043431834,"RPAP3","RNA polymerase II associated protein 3",TRUE
+"213964_x_at",0.819018525257656,0.375277986486195,0.904852214439967,-5.54857616971847,0.690454047642051,"RPARP-AS1","RPARP antisense RNA 1",TRUE
+"214857_at",0.902960767180391,0.602650962143204,-0.528141919950766,-5.80473070777418,-0.20524426598602,"RPARP-AS1","RPARP antisense RNA 1",TRUE
+"221770_at",0.62110896023334,0.0913722666797446,-1.76484157456031,-4.52681547586128,-0.702344341508596,"RPE","ribulose-5-phosphate-3-epimerase",TRUE
+"225040_s_at",0.640839095542136,0.111315115907527,-1.65846423152852,-4.68206047011054,-0.607814918200194,"RPE","ribulose-5-phosphate-3-epimerase",TRUE
+"1558519_at",0.703749074459589,0.175271168667878,-1.40030228325767,-5.02725075952377,-1.17695845590839,"RPE","ribulose-5-phosphate-3-epimerase",TRUE
+"225039_at",0.778007390824139,0.29725985387486,-1.06745454594997,-5.39942984264947,-0.381521611330239,"RPE","ribulose-5-phosphate-3-epimerase",TRUE
+"207107_at",0.707898177720919,0.179764604111097,-1.38525158252844,-5.04591575065093,-0.991832915469655,"RPE65","RPE65, retinoid isomerohydrolase",TRUE
+"216574_s_at",0.875723781180194,0.523271987766931,-0.648585911721394,-5.73684480973741,-0.255444355295207,"RPEL1///RPE","ribulose-5-phosphate-3-epimerase like 1///ribulose-5-phosphate-3-epimerase",TRUE
+"234243_at",0.870433264908839,0.508982568128038,0.67127709257389,-5.72255799298974,0.26656132682669,"RPF1","ribosome production factor 1 homolog",TRUE
+"234244_at",0.928819762424586,0.686703343377535,-0.408672042142104,-5.85866345358531,-0.345374694060273,"RPF1","ribosome production factor 1 homolog",TRUE
+"218462_at",0.995628848184154,0.97924493426826,-0.0263108567250671,-5.93934631147584,-0.00810025230052602,"RPF1","ribosome production factor 1 homolog",TRUE
+"225866_at",0.747652283046971,0.239535894689233,1.20865696790775,-5.2521525735636,0.519772703543106,"RPF2","ribosome production factor 2 homolog",TRUE
+"207624_s_at",0.988713664405312,0.945672245610881,-0.0689190756917558,-5.93737027408166,-0.0281223461413553,"RPGR","retinitis pigmentosa GTPase regulator",TRUE
+"206608_s_at",0.737123149977386,0.223085452177344,1.25351251443132,-5.20203822855122,0.438088359255112,"RPGRIP1","retinitis pigmentosa GTPase regulator interacting protein 1",TRUE
+"213959_s_at",0.790309297261437,0.319949792054347,1.0173890564818,-5.44772987116386,0.460566836656014,"RPGRIP1L","RPGRIP1 like",TRUE
+"241028_at",0.999125149395027,0.997133294959105,0.00363364520182126,-5.9396770498728,0.00244003517304892,"RPGRIP1L","RPGRIP1 like",TRUE
+"205230_at",0.959203345279235,0.815347602814135,-0.236330104932946,-5.91251662477422,-0.118963429782236,"RPH3A","rabphilin 3A",TRUE
+"221614_s_at",0.620912785033482,0.0907571275475361,-1.76842739584545,-4.52145773139473,-1.25177183706442,"RPH3AL","rabphilin 3A-like (without C2 domains)",TRUE
+"238120_at",0.910165867297668,0.626538753272922,-0.493466648197816,-5.82177000927675,-0.288559312586586,"RPH3AL","rabphilin 3A-like (without C2 domains)",TRUE
+"233134_at",0.965992617204023,0.841086641381002,0.202871843644758,-5.91965728910736,0.140176875129596,"RPH3AL","rabphilin 3A-like (without C2 domains)",TRUE
+"212973_at",0.922635094827638,0.669177945883508,-0.43303172507601,-5.84876153235993,-0.209526537609213,"RPIA","ribose 5-phosphate isomerase A",TRUE
+"201757_at",0.961212424803935,0.823561955833609,-0.225624108160065,-5.91491930070906,-0.0577387216994936,"RPL10///NDUFS5","ribosomal protein L10///NADH:ubiquinone oxidoreductase subunit S5",TRUE
+"200036_s_at",0.854400503339099,0.465547362160636,0.742561718354892,-5.67462833439165,0.194767664432632,"RPL10A","ribosomal protein L10a",TRUE
+"229563_s_at",0.940044918888428,0.731581105823288,0.347383857501396,-5.88107718727034,0.0706584653489859,"RPL10A","ribosomal protein L10a",TRUE
+"217559_at",0.951810226174863,0.77917709976046,0.283828614937256,-5.90052230782133,0.190133605984993,"RPL10L","ribosomal protein L10 like",TRUE
+"200010_at",0.854184492233394,0.464373382145741,0.744541200912777,-5.67323184201555,0.169175968717324,"RPL11","ribosomal protein L11",TRUE
+"200809_x_at",0.921763460627549,0.666569432213846,0.436679982275903,-5.84723008031323,0.121329356799787,"RPL12","ribosomal protein L12",TRUE
+"214271_x_at",0.936759298111847,0.717453966317944,0.366519906542029,-5.87446393063882,0.111748693034906,"RPL12","ribosomal protein L12",TRUE
+"1555083_at",0.879948283821082,0.534889459767603,0.630387389337403,-5.74796198272023,0.264324553250931,"RPL13AP17","ribosomal protein L13a pseudogene 17",TRUE
+"211942_x_at",0.932249295738588,0.701091361469876,0.388860211258572,-5.86630073331023,0.0860769995899346,"RPL13AP5///RPL13AP6///SNORD32A///SNORD33///SNORD34///SNORD35A///RPL13A","ribosomal protein L13a pseudogene 5///ribosomal protein L13a pseudogene 6///small nucleolar RNA, C/D box 32A///small nucleolar RNA, C/D box 33///small nucleolar RNA, C/D box 34///small nucleolar RNA, C/D box 35A///ribosomal protein L13a",TRUE
+"210646_x_at",0.973071267819624,0.870728429282062,-0.164629336360805,-5.92649131242576,-0.0363058141532289,"RPL13AP5///SNORD32A///SNORD33///SNORD34///SNORD35A///RPL13A","ribosomal protein L13a pseudogene 5///small nucleolar RNA, C/D box 32A///small nucleolar RNA, C/D box 33///small nucleolar RNA, C/D box 34///small nucleolar RNA, C/D box 35A///ribosomal protein L13a",TRUE
+"212790_x_at",0.975398143273847,0.881350283412747,0.150989443909347,-5.92858560349844,0.0345559644348139,"RPL13AP5///SNORD32A///SNORD33///SNORD34///SNORD35A///RPL13A","ribosomal protein L13a pseudogene 5///small nucleolar RNA, C/D box 32A///small nucleolar RNA, C/D box 33///small nucleolar RNA, C/D box 34///small nucleolar RNA, C/D box 35A///ribosomal protein L13a",TRUE
+"200716_x_at",0.975711087363387,0.884091503961035,0.147474209140814,-5.92909606738722,0.0323978125470088,"RPL13AP5///SNORD32A///SNORD33///SNORD34///SNORD35A///RPL13A","ribosomal protein L13a pseudogene 5///small nucleolar RNA, C/D box 32A///small nucleolar RNA, C/D box 33///small nucleolar RNA, C/D box 34///small nucleolar RNA, C/D box 35A///ribosomal protein L13a",TRUE
+"210822_at",0.690381347688918,0.160161275581769,1.4532888253057,-4.96022317899047,1.04735070085746,"RPL13P5///LRRC23","ribosomal protein L13 pseudogene 5///leucine rich repeat containing 23",TRUE
+"217609_at",0.740610299769501,0.230059219045789,1.23420024318555,-5.22380768131094,0.558062428082334,"RPL13P5///LRRC23","ribosomal protein L13 pseudogene 5///leucine rich repeat containing 23",TRUE
+"219138_at",0.638323853744235,0.109580387585613,1.66704396684614,-4.66980915692789,1.04829812239471,"RPL14","ribosomal protein L14",TRUE
+"200074_s_at",0.885029460971826,0.545654486202728,0.613713564614671,-5.75788036117054,0.175135867448619,"RPL14","ribosomal protein L14",TRUE
+"213588_x_at",0.931582451098271,0.698137501907222,0.392914415185972,-5.86476829040254,0.0999985250618813,"RPL14","ribosomal protein L14",TRUE
+"240806_at",0.650298942402444,0.120459304030988,-1.6150145815404,-4.7433591316557,-1.18744539237596,"RPL15","ribosomal protein L15",TRUE
+"221476_s_at",0.966773610653397,0.845524645761511,-0.197127815753272,-5.92077421575472,-0.0657265603142854,"RPL15","ribosomal protein L15",TRUE
+"217266_at",0.980832655742,0.910113778528901,-0.114192353386766,-5.93333422449461,-0.051249484026707,"RPL15","ribosomal protein L15",TRUE
+"221475_s_at",0.989586772349659,0.949641312695783,0.0638765529421616,-5.93769635432911,0.0203672790527047,"RPL15","ribosomal protein L15",TRUE
+"224957_at",0.595019326272843,0.071805764284401,-1.8907563281389,-4.33400040259516,-0.843772191813191,"RPL17-C18orf32///C18orf32///RPL17","RPL17-C18orf32 readthrough///chromosome 18 open reading frame 32///ribosomal protein L17",TRUE
+"212270_x_at",0.974982245454858,0.87815222905374,-0.155092971284605,-5.92797453365658,-0.042374326814933,"RPL17-C18orf32///SNORD58C///C18orf32///SNORD58A///SNORD58B///RPL17","RPL17-C18orf32 readthrough///small nucleolar RNA, C/D box 58C///chromosome 18 open reading frame 32///small nucleolar RNA, C/D box 58A///small nucleolar RNA, C/D box 58B///ribosomal protein L17",TRUE
+"212537_x_at",0.975398143273847,0.881124390687802,-0.151279206243439,-5.92854299047089,-0.0407586036399543,"RPL17-C18orf32///SNORD58C///C18orf32///SNORD58A///SNORD58B///RPL17","RPL17-C18orf32 readthrough///small nucleolar RNA, C/D box 58C///chromosome 18 open reading frame 32///small nucleolar RNA, C/D box 58A///small nucleolar RNA, C/D box 58B///ribosomal protein L17",TRUE
+"200038_s_at",0.979588787486838,0.902871248001935,-0.123440470336533,-5.93226455619262,-0.0285854514727788,"RPL17-C18orf32///SNORD58C///C18orf32///SNORD58A///SNORD58B///RPL17","RPL17-C18orf32 readthrough///small nucleolar RNA, C/D box 58C///chromosome 18 open reading frame 32///small nucleolar RNA, C/D box 58A///small nucleolar RNA, C/D box 58B///ribosomal protein L17",TRUE
+"214291_at",0.992294016310421,0.963784232509492,0.0459214617052204,-5.93865642364143,0.0176961319563471,"RPL17-C18orf32///SNORD58C///SNORD58A///SNORD58B///RPL17","RPL17-C18orf32 readthrough///small nucleolar RNA, C/D box 58C///small nucleolar RNA, C/D box 58A///small nucleolar RNA, C/D box 58B///ribosomal protein L17",TRUE
+"200022_at",0.971826767527606,0.865139369882307,-0.171819132311389,-5.92531471448922,-0.0452694948443941,"RPL18","ribosomal protein L18",TRUE
+"222297_x_at",0.990810941805126,0.954374431291063,0.0578655434625108,-5.93805271986811,0.0222475685568959,"RPL18","ribosomal protein L18",TRUE
+"214335_at",0.998347572104896,0.99207067581301,0.0100508392401062,-5.93963427805857,0.00299357496894448,"RPL18","ribosomal protein L18",TRUE
+"200029_at",0.968767226337314,0.852727782985086,-0.187819260856804,-5.92251639659155,-0.0513141535734629,"RPL19","ribosomal protein L19",TRUE
+"216479_at",0.786258836947875,0.311647740401359,-1.03540765758668,-5.43058727830052,-0.599280275000113,"RPL21P28///SNORA27///SNORD102///RPL21","ribosomal protein L21 pseudogene 28///small nucleolar RNA, H/ACA box 27///small nucleolar RNA, C/D box 102///ribosomal protein L21",TRUE
+"200012_x_at",0.914548427579679,0.639946439355046,0.474272279291796,-5.83071621054476,0.112173835312174,"RPL21P28///SNORA27///SNORD102///RPL21","ribosomal protein L21 pseudogene 28///small nucleolar RNA, H/ACA box 27///small nucleolar RNA, C/D box 102///ribosomal protein L21",TRUE
+"221775_x_at",0.806086691531913,0.346431916311695,0.961999428256559,-5.49871470797457,0.208353235327786,"RPL22","ribosomal protein L22",TRUE
+"208768_x_at",0.819018525257656,0.374929662454705,0.905524477658746,-5.54800596174943,0.19614222275559,"RPL22","ribosomal protein L22",TRUE
+"220960_x_at",0.84113463994907,0.430990158905774,0.802142979360861,-5.63105795007339,0.16884342290474,"RPL22","ribosomal protein L22",TRUE
+"214042_s_at",0.849935057946582,0.452344527316497,0.764998037048772,-5.65859379885843,0.250665178169303,"RPL22","ribosomal protein L22",TRUE
+"221726_at",0.950213309729358,0.773778640861092,-0.290972591226925,-5.89853018241113,-0.10563090341825,"RPL22","ribosomal protein L22",TRUE
+"225541_at",0.729273475042162,0.211716240261587,1.28601242929941,-5.16475033310482,0.901076640354457,"RPL22L1","ribosomal protein L22 like 1",TRUE
+"203012_x_at",0.969882914559333,0.857039283432226,-0.18225571152349,-5.92351757290094,-0.0406778880435397,"RPL23A","ribosomal protein L23a",TRUE
+"207283_at",0.975398143273847,0.881553647403073,0.150728591476068,-5.928623895252,0.0601009642851853,"RPL23AP32","ribosomal protein L23a pseudogene 32",TRUE
+"222225_at",0.918589448829797,0.654160014259478,-0.454119565283145,-5.8397352029232,-0.308963014290998,"RPL23AP53","ribosomal protein L23a pseudogene 53",TRUE
+"221634_at",0.852503125709186,0.458480955494107,0.754521934807576,-5.66613695958696,0.242623994531225,"RPL23AP7///CENPBD1P1","ribosomal protein L23a pseudogene 7///CENPB DNA-binding domains containing 1 pseudogene 1",TRUE
+"200013_at",0.983869758743232,0.921085641902718,-0.100201320735326,-5.93479440144408,-0.0273927554370097,"RPL24","ribosomal protein L24",TRUE
+"214143_x_at",0.986280972175967,0.932854822569073,0.0852162373989165,-5.93614714109578,0.0202967093280808,"RPL24","ribosomal protein L24",TRUE
+"218830_at",0.778397054392363,0.298110627507376,-1.06552925297465,-5.40132574848321,-0.350457942114284,"RPL26L1","ribosomal protein L26 like 1",TRUE
+"200025_s_at",0.956084625435459,0.801452784549095,0.254504821256221,-5.90818423541817,0.0561731966375394,"RPL27","ribosomal protein L27",TRUE
+"212044_s_at",0.817560991958296,0.370059431714383,0.914967580000088,-5.53995510084895,0.280133349120019,"RPL27A","ribosomal protein L27a",TRUE
+"200823_x_at",0.947778780715578,0.762013416677961,-0.306596232157347,-5.8940023639772,-0.104525045326922,"RPL29","ribosomal protein L29",TRUE
+"213969_x_at",0.985498770484702,0.929808052196018,-0.0890934722548687,-5.93581808504041,-0.0280356389897864,"RPL29","ribosomal protein L29",TRUE
+"215963_x_at",0.896478944115417,0.58112495175745,0.559959302104608,-5.78810590200694,0.139718872881391,"RPL3","ribosomal protein L3",TRUE
+"200062_s_at",0.972112264314695,0.866284128993072,-0.170345765598077,-5.92555991380375,-0.0374270584069034,"RPL30","ribosomal protein L30",TRUE
+"221593_s_at",0.871206814961775,0.511909198729607,0.666601149840465,-5.72554057096533,0.356950087238108,"RPL31","ribosomal protein L31",TRUE
+"200963_x_at",0.95018792835023,0.773450338344038,0.291407541161935,-5.8984073085936,0.0672222467919816,"RPL31","ribosomal protein L31",TRUE
+"200962_at",0.9550451679854,0.794814178942326,0.263218898304471,-5.90599393529621,0.133200799066836,"RPL31","ribosomal protein L31",TRUE
+"200674_s_at",0.986342822130003,0.933963380687927,0.0838058525281909,-5.9362632102642,0.0191540240229955,"RPL32","ribosomal protein L32",TRUE
+"1558969_a_at",0.835513930382091,0.414891992430212,0.830904756426132,-5.60889469941544,0.406157311634471,"RPL32P3","ribosomal protein L32 pseudogene 3",TRUE
+"226877_at",0.867580082241907,0.500327340388022,0.685194767013456,-5.71356249074073,0.606604507777975,"RPL32P3","ribosomal protein L32 pseudogene 3",TRUE
+"235314_at",0.971216837324271,0.861830617025905,0.17607987755037,-5.92459378807243,0.0578078391822077,"RPL32P3","ribosomal protein L32 pseudogene 3",TRUE
+"200026_at",0.986342822130003,0.93475041291555,-0.0828046411819735,-5.93634443122422,-0.0246357216443229,"RPL34","ribosomal protein L34",TRUE
+"1563581_at",0.82064687791745,0.381358197778866,0.893183104547093,-5.5584114231476,0.622684766648987,"RPL34-AS1","RPL34 antisense RNA 1 (head to head)",TRUE
+"200002_at",0.990810941805126,0.956468397949073,0.0552069388305991,-5.93819911579677,0.0120777643717869,"RPL35","ribosomal protein L35",TRUE
+"215249_at",0.673303044934899,0.138872488537491,1.53528031264435,-4.85254526683611,0.834651362979704,"RPL35A","ribosomal protein L35a",TRUE
+"213687_s_at",0.760323325310287,0.258935919951387,1.15864755126627,-5.30615208114528,0.277317550552739,"RPL35A","ribosomal protein L35a",TRUE
+"225190_x_at",0.768852835478002,0.273399311639203,1.12314389082897,-5.34327195583372,0.389010580288302,"RPL35A","ribosomal protein L35a",TRUE
+"238026_at",0.856257656023992,0.470081861276947,0.734943640430635,-5.6799698632748,0.302232061443075,"RPL35A","ribosomal protein L35a",TRUE
+"215208_x_at",0.955904644595647,0.800536851223106,0.255705896513277,-5.90788669589961,0.13704139558981,"RPL35A","ribosomal protein L35a",TRUE
+"231658_x_at",0.882059205223864,0.539446525963617,0.623307293471822,-5.75220484100757,0.337651788659246,"RPL36","ribosomal protein L36",TRUE
+"219762_s_at",0.962555471240652,0.829394139062493,-0.218039271210905,-5.91655444387465,-0.065650270865671,"RPL36","ribosomal protein L36",TRUE
+"243201_at",0.668587404382295,0.134861203446605,-1.55186938110881,-4.83018663765187,-0.793889916950191,"RPL36A","ribosomal protein L36a",TRUE
+"201132_at",0.816800680706682,0.36817035170107,-0.918652587244843,-5.53679249947253,-0.290812525983437,"RPL36A-HNRNPH2///HNRNPH2","RPL36A-HNRNPH2 readthrough///heterogeneous nuclear ribonucleoprotein H2 (H')",TRUE
+"201406_at",0.953622331321215,0.786467413216469,0.274204887930256,-5.90312822986152,0.0659546127826847,"RPL36A-HNRNPH2///RPL36A","RPL36A-HNRNPH2 readthrough///ribosomal protein L36a",TRUE
+"207585_s_at",0.734730148360473,0.219375326593921,-1.26397548290363,-5.19012290140135,-0.445828033765732,"RPL36AL","ribosomal protein L36a like",TRUE
+"200092_s_at",0.697172073261335,0.167602745966984,1.42671426962665,-4.99409472249711,0.319468623355181,"RPL37","ribosomal protein L37",TRUE
+"213459_at",0.764077045023402,0.264075214113595,-1.14586857127188,-5.31962996585158,-0.48496887358009,"RPL37A","ribosomal protein L37a",TRUE
+"201429_s_at",0.991367768700244,0.959770570108252,-0.051015156884773,-5.93841595593203,-0.0109352207026241,"RPL37A","ribosomal protein L37a",TRUE
+"214041_x_at",0.995375928428862,0.97848615017232,0.0272729997807123,-5.93932120164179,0.0103406252748837,"RPL37A","ribosomal protein L37a",TRUE
+"221943_x_at",0.683019114815084,0.151701874568058,1.48473908052846,-4.9194820366523,0.478130676772256,"RPL38","ribosomal protein L38",TRUE
+"202028_s_at",0.726696341943087,0.206705591226456,1.30076442568774,-5.14755694836244,0.389679582057768,"RPL38","ribosomal protein L38",TRUE
+"202029_x_at",0.962351204352784,0.828303720566344,0.219456368385737,-5.91625317242026,0.0497045641862783,"RPL38","ribosomal protein L38",TRUE
+"208695_s_at",0.921294973929502,0.664304113851876,0.439853139612317,-5.84588780761608,0.0907847444883991,"RPL39","ribosomal protein L39",TRUE
+"210115_at",0.868397087637799,0.504291989503092,0.678802875414314,-5.71771572720245,0.945366916383481,"RPL39L","ribosomal protein L39 like",TRUE
+"206768_at",0.846015118644589,0.443962379095788,0.779447819565025,-5.64802828152672,0.479455687589411,"RPL3L","ribosomal protein L3 like",TRUE
+"201492_s_at",0.975265330414469,0.880066803265725,0.152635996035988,-5.92834237375445,0.032175117837669,"RPL41","ribosomal protein L41",TRUE
+"200937_s_at",0.831487912516861,0.40587346426031,0.847325996716428,-5.5959133936972,0.209031440291623,"RPL5///SNORD21","ribosomal protein L5///small nucleolar RNA, C/D box 21",TRUE
+"210034_s_at",0.932018790587499,0.699442085997373,0.391123037063933,-5.86544734213803,0.173544082127184,"RPL5///SNORD21","ribosomal protein L5///small nucleolar RNA, C/D box 21",TRUE
+"213080_x_at",0.962966981693287,0.83197978111818,0.214680814855585,-5.91726068506325,0.046633967817117,"RPL5///SNORD21","ribosomal protein L5///small nucleolar RNA, C/D box 21",TRUE
+"200034_s_at",0.988920414897503,0.946426014357618,0.0679613093329289,-5.93743411336572,0.0137544216474534,"RPL6","ribosomal protein L6",TRUE
+"239493_at",0.954456115752166,0.791381749369911,0.26773256816523,-5.90483062199933,0.167405088989578,"RPL7","ribosomal protein L7",TRUE
+"212042_x_at",0.991328040460654,0.959326321367594,-0.0515790306313715,-5.93838778282102,-0.0106410603142457,"RPL7","ribosomal protein L7",TRUE
+"200717_x_at",0.997128956162635,0.985374236421212,0.0185397153072255,-5.93951606828829,0.00383444762401197,"RPL7","ribosomal protein L7",TRUE
+"234875_at",0.984734424176794,0.925155064777127,0.0950174563018442,-5.9352870769163,0.0423053881707336,"RPL7AP10","ribosomal protein L7a pseudogene 10",TRUE
+"234254_at",0.594972224548427,0.071682665551821,-1.8916387969519,-4.33261580375291,-0.929757227276017,"RPL7AP9","ribosomal protein L7a pseudogene 9",TRUE
+"224738_x_at",0.92563477467988,0.678522220876583,-0.420011318569954,-5.85412426846634,-0.143599427993649,"RPL7L1","ribosomal protein L7 like 1",TRUE
+"225515_s_at",0.90808139498617,0.618624741089161,-0.504884683022505,-5.81628381947915,-0.179197761407837,"RPL7L1///WAC-AS1","ribosomal protein L7 like 1///WAC antisense RNA 1 (head to head)",TRUE
+"200936_at",0.886783047600321,0.550323929437281,0.606535554382209,-5.7620712511717,0.163320131335016,"RPL8","ribosomal protein L8",TRUE
+"200032_s_at",0.990810941805126,0.956788794763266,0.054800183492109,-5.9382209067383,0.0117534452104504,"RPL9","ribosomal protein L9",TRUE
+"214167_s_at",0.943464796017993,0.747194196835718,0.326387419408574,-5.88793003552667,0.079117168303517,"RPLP0","ribosomal protein lateral stalk subunit P0",TRUE
+"211972_x_at",0.975913043793143,0.884791500352986,0.146576867642779,-5.92922445215371,0.0315135648719824,"RPLP0","ribosomal protein lateral stalk subunit P0",TRUE
+"201033_x_at",0.980174445251813,0.906803756424763,0.118417664469065,-5.93285582667154,0.0263339697872862,"RPLP0","ribosomal protein lateral stalk subunit P0",TRUE
+"211720_x_at",0.982925605058683,0.917361276176214,0.10494809448814,-5.93432034095649,0.0235194811384023,"RPLP0","ribosomal protein lateral stalk subunit P0",TRUE
+"208856_x_at",0.99951242185416,0.998949322135842,-0.00133176693253176,-5.93968261689243,-0.000295641939317193,"RPLP0","ribosomal protein lateral stalk subunit P0",TRUE
+"244191_at",0.854246455748088,0.464972556434625,-0.743530544164958,-5.6739452840443,-0.26725107868388,"RPLP1","ribosomal protein lateral stalk subunit P1",TRUE
+"200763_s_at",0.975159323713639,0.87895185992772,0.154066686099182,-5.92812889416409,0.0306428637048484,"RPLP1","ribosomal protein lateral stalk subunit P1",TRUE
+"200908_s_at",0.746172020724,0.237642311785405,1.21369901072737,-5.24659815386659,0.617403314273226,"RPLP2","ribosomal protein lateral stalk subunit P2",TRUE
+"217670_at",0.885029460971826,0.545215790263729,0.614389608536798,-5.75748320194709,0.456536699511101,"RPLP2","ribosomal protein lateral stalk subunit P2",TRUE
+"201011_at",0.919354071504066,0.656571122187537,0.450720068993839,-5.84121876362834,0.144632997364587,"RPN1","ribophorin I",TRUE
+"208689_s_at",0.897699110987203,0.585083911685603,-0.554064558643573,-5.79125722024101,-0.180830151152119,"RPN2","ribophorin II",TRUE
+"213399_x_at",0.937612755058333,0.723271009133421,-0.358623894690398,-5.87723516174627,-0.116659916014703,"RPN2","ribophorin II",TRUE
+"213491_x_at",0.991059530537351,0.958302004841475,0.0528792354478444,-5.93832163999727,0.0185885705870987,"RPN2","ribophorin II",TRUE
+"236380_at",0.170374697680568,0.00143030610398501,-3.64064900429184,-0.972044283983817,-2.19412053068252,"RPP14","ribonuclease P/MRP subunit p14",TRUE
+"204245_s_at",0.364513221153898,0.0106685902735622,-2.78845241749159,-2.72980082061459,-0.676397775196856,"RPP14","ribonuclease P/MRP subunit p14",TRUE
+"227005_at",0.982723176827697,0.916057968545046,0.10660976234245,-5.93414921162441,0.0335499237954799,"RPP14","ribonuclease P/MRP subunit p14",TRUE
+"219143_s_at",0.941106542715586,0.736117734429276,-0.341267011665732,-5.88311721537364,-0.19707234209003,"RPP25","ribonuclease P/MRP subunit p25",TRUE
+"223415_at",0.98539961718117,0.928630997774511,-0.0905917302856573,-5.93568701143695,-0.0369945841414321,"RPP25","ribonuclease P/MRP subunit p25",TRUE
+"225403_at",0.581852599439475,0.0640750716641766,-1.94894168238001,-4.24174892133901,-0.594218492205906,"RPP25L","ribonuclease P/MRP subunit p25 like",TRUE
+"1556063_s_at",0.7717895132349,0.281285397833112,1.10436213358467,-5.36249544938797,0.547995001015424,"RPP30","ribonuclease P/MRP subunit p30",TRUE
+"203436_at",0.911483438892151,0.629811300190335,0.48876459592767,-5.82399364259355,0.169773064041319,"RPP30","ribonuclease P/MRP subunit p30",TRUE
+"1556062_at",0.931370027472813,0.696545197869658,0.395102648910913,-5.86393465608699,0.281915696488912,"RPP30","ribonuclease P/MRP subunit p30",TRUE
+"1556061_at",0.957430653957785,0.807695352952508,0.24632894205141,-5.91017262766984,0.0960835731772569,"RPP30","ribonuclease P/MRP subunit p30",TRUE
+"205562_at",0.918373706340477,0.653279081822023,-0.455362974026614,-5.83918984231226,-0.11099189147396,"RPP38","ribonuclease P/MRP subunit p38",TRUE
+"213427_at",0.813442508625161,0.363864408801932,0.927099456595133,-5.52949893076342,0.440822471295254,"RPP40","ribonuclease P/MRP subunit p40",TRUE
+"1556684_at",0.689848451630875,0.158756683850078,1.45841611350995,-4.95362944642898,1.45567047231762,"RPPH1","ribonuclease P RNA component H1",TRUE
+"218209_s_at",0.562894650172193,0.0555339565613974,-2.02092431599583,-4.12499392311055,-0.880707831396068,"RPRD1A","regulation of nuclear pre-mRNA domain containing 1A",TRUE
+"222558_at",0.682539393883246,0.150350537053645,-1.48989429114946,-4.91273675513284,-0.69610639596886,"RPRD1A","regulation of nuclear pre-mRNA domain containing 1A",TRUE
+"228566_at",0.700430227058786,0.172124292154284,1.41102686207542,-5.01384922069905,0.493259889952624,"RPRD1A","regulation of nuclear pre-mRNA domain containing 1A",TRUE
+"225953_at",0.758675417148131,0.25563927224728,-1.16694389365263,-5.29733178714776,-0.459820160439351,"RPRD1A","regulation of nuclear pre-mRNA domain containing 1A",TRUE
+"222559_s_at",0.812302873476553,0.359561965547473,-0.935606460403295,-5.52209138405118,-0.462329169454266,"RPRD1A","regulation of nuclear pre-mRNA domain containing 1A",TRUE
+"1555202_a_at",0.913468969775679,0.63715616499802,-0.478251714640394,-5.82888997324102,-0.167755088721206,"RPRD1A","regulation of nuclear pre-mRNA domain containing 1A",TRUE
+"225024_at",0.83030603167465,0.402602964999117,-0.853338424822635,-5.59110117480925,-0.321945345090036,"RPRD1B","regulation of nuclear pre-mRNA domain containing 1B",TRUE
+"230801_at",0.998870448604467,0.995927433731907,-0.00516212701443455,-5.93967050171573,-0.00246173807670313,"RPRD1B","regulation of nuclear pre-mRNA domain containing 1B",TRUE
+"226527_at",0.46481156911694,0.0239491111244282,-2.42412871916362,-3.42269563636286,-0.711869104597151,"RPRD2","regulation of nuclear pre-mRNA domain containing 2",TRUE
+"212553_at",0.768852835478002,0.27403547726702,-1.12161424531176,-5.34484831689432,-0.371904421921077,"RPRD2","regulation of nuclear pre-mRNA domain containing 2",TRUE
+"235415_at",0.94895689004559,0.769276165316131,-0.296942712295331,-5.89682772022946,-0.0956830264624848,"RPRD2","regulation of nuclear pre-mRNA domain containing 2",TRUE
+"219370_at",0.98539961718117,0.928512706952003,-0.0907423129031985,-5.93567371707814,-0.0630305077280795,"RPRM","reprimo, TP53 dependent G2 arrest mediator candidate",TRUE
+"1554655_a_at",0.839519981963042,0.428215046453438,-0.807052675858928,-5.62732647947698,-0.538261394131034,"RPRML","reprimo like",TRUE
+"214001_x_at",0.805746717966166,0.345558324208533,0.963779345335552,-5.49711678698834,0.27742546084923,"RPS10","ribosomal protein S10",TRUE
+"200817_x_at",0.854400503339099,0.465488126643947,0.742661526008677,-5.67455800610522,0.155764876809846,"RPS10","ribosomal protein S10",TRUE
+"200095_x_at",0.855871649170573,0.469238382360075,0.736357403859174,-5.67898253117894,0.147904880745772,"RPS10","ribosomal protein S10",TRUE
+"211542_x_at",0.892780783477555,0.566006382278752,0.582658438714142,-5.77566913340496,0.120045726594617,"RPS10","ribosomal protein S10",TRUE
+"221579_s_at",0.905306717560218,0.611038516819514,-0.515893996017081,-5.81087810032964,-0.147266448363688,"RPS10-NUDT3///NUDT3","RPS10-NUDT3 readthrough///nudix hydrolase 3",TRUE
+"229803_s_at",0.953564723226096,0.785858807225961,0.275007266781566,-5.90291437019276,0.0875194355244027,"RPS10-NUDT3///NUDT3","RPS10-NUDT3 readthrough///nudix hydrolase 3",TRUE
+"1566720_at",0.884803041417939,0.544801360645819,0.615028522470786,-5.75710746818959,0.225877729864296,"RPS10P7","ribosomal protein S10 pseudogene 7",TRUE
+"213350_at",0.92781038684564,0.683431833924487,0.41319982903499,-5.85686560547986,0.162523507948928,"RPS11","ribosomal protein S11",TRUE
+"233149_at",0.823073978212882,0.388907561574061,0.878862937531846,-5.57031951166938,0.419941625353138,"RPS11P6","ribosomal protein S11 pseudogene 6",TRUE
+"217723_x_at",0.681231910132377,0.149129670459523,1.49458433072207,-4.9065837892961,0.75728211731274,"RPS12","ribosomal protein S12",TRUE
+"213377_x_at",0.831013183269159,0.40502678203487,0.848879541920574,-5.59467300928921,0.207386626300236,"RPS12","ribosomal protein S12",TRUE
+"217298_at",0.319095917986488,0.00703566426470245,2.96989083020801,-2.36872333539447,1.31374727335807,"RPS14","ribosomal protein S14",TRUE
+"214245_at",0.883016663633454,0.540650579110929,0.621441975540655,-5.7533149807205,0.185508447052613,"RPS14","ribosomal protein S14",TRUE
+"241241_at",0.952239474918707,0.781368971238455,0.280932353392589,-5.90131594379035,0.194933815073971,"RPS14","ribosomal protein S14",TRUE
+"208645_s_at",0.986342822130003,0.933457676103555,-0.0844492233514247,-5.93621050346255,-0.0181884977435569,"RPS14","ribosomal protein S14",TRUE
+"1563014_at",0.777463110382572,0.296394385037217,1.06941713803326,-5.39749405377223,0.364255716409285,"RPS15","ribosomal protein S15",TRUE
+"200819_s_at",0.947778780715578,0.761717424318246,-0.30699028509295,-5.89388513112428,-0.065335913377421,"RPS15","ribosomal protein S15",TRUE
+"200781_s_at",0.948429371744093,0.765746673476817,-0.301630396478719,-5.89546693602685,-0.0622447868339009,"RPS15A","ribosomal protein S15a",TRUE
+"229882_at",0.969642324744141,0.855141052057808,-0.184704448555684,-5.92308061248311,-0.051659635104234,"RPS15A","ribosomal protein S15a",TRUE
+"235309_at",0.985498770484702,0.930155133699017,-0.088651716542718,-5.93585631466009,-0.0387333556855172,"RPS15A","ribosomal protein S15a",TRUE
+"226130_at",0.642592458809121,0.112747256168755,1.65146562115588,-4.69201833275257,0.5609449890113,"RPS16","ribosomal protein S16",TRUE
+"213890_x_at",0.912252515563073,0.632347764615009,0.485127836019117,-5.82569922279734,0.116221044117717,"RPS16","ribosomal protein S16",TRUE
+"201258_at",0.916349280948806,0.646832814795395,0.464484057883443,-5.83514465367581,0.109568294151989,"RPS16","ribosomal protein S16",TRUE
+"226131_s_at",0.957921219123575,0.810593198426544,0.242539498623083,-5.91107233966509,0.0495738563530743,"RPS16","ribosomal protein S16",TRUE
+"1566079_at",0.98453870130544,0.924636391118714,0.0956780212317122,-5.93522575003295,0.0631673391131953,"RPS16P5","ribosomal protein S16 pseudogene 5",TRUE
+"211487_x_at",0.919695424525124,0.658732373476514,0.447677432652348,-5.84253731787669,0.102539356313635,"RPS17","ribosomal protein S17",TRUE
+"201665_x_at",0.979588787486838,0.902919340446421,0.123379024765965,-5.93227193755618,0.0270598844026235,"RPS17","ribosomal protein S17",TRUE
+"212578_x_at",0.986145735582101,0.932239361518832,0.0859993461026307,-5.93608185853092,0.0200920450414728,"RPS17","ribosomal protein S17",TRUE
+"201049_s_at",0.979588787486838,0.902049207757193,0.124490829955152,-5.9321378105469,0.026323395559098,"RPS18","ribosomal protein S18",TRUE
+"242451_x_at",0.712948021516228,0.186968981130322,-1.36173227637438,-5.07474755847303,-0.380644101703736,"RPS19","ribosomal protein S19",TRUE
+"202649_x_at",0.740634842876843,0.230777933470479,-1.23223537651427,-5.22600623191975,-0.30086293805274,"RPS19","ribosomal protein S19",TRUE
+"213414_s_at",0.798401804604592,0.332591121268172,-0.990569188000533,-5.4727409218112,-0.228150723325395,"RPS19","ribosomal protein S19",TRUE
+"225148_at",0.800393752157075,0.336216612817404,-0.983007866270143,-5.47968257739174,-0.401882218488392,"RPS19BP1","ribosomal protein S19 binding protein 1",TRUE
+"200834_s_at",0.961395512423249,0.825031718557232,-0.223711402701373,-5.91533688929576,-0.0532128843538455,"RPS21","ribosomal protein S21",TRUE
+"214097_at",0.980009054680439,0.905652374246827,-0.119887941209503,-5.9326852885438,-0.0835815627014913,"RPS21","ribosomal protein S21",TRUE
+"227722_at",0.667209925683767,0.133772835234807,-1.55644059963549,-4.82399222877888,-1.11121405497175,"RPS23","ribosomal protein S23",TRUE
+"200926_at",0.973071267819624,0.870076171293374,0.165467939391069,-5.92635666014229,0.0354732076463247,"RPS23","ribosomal protein S23",TRUE
+"1555878_at",0.849646596450765,0.450904512879254,0.767468820689661,-5.65680042126347,0.398694228632676,"RPS24","ribosomal protein S24",TRUE
+"200061_s_at",0.978928101156583,0.897316669482392,0.130540646434074,-5.93138691280591,0.026625801401849,"RPS24","ribosomal protein S24",TRUE
+"200091_s_at",0.94632739401154,0.757475680615872,0.312642781409537,-5.89218706420189,0.0720756296886318,"RPS25","ribosomal protein S25",TRUE
+"236621_at",0.726636642789909,0.206072004398694,1.30264945906571,-5.14534796229218,0.646866174504966,"RPS27","ribosomal protein S27",TRUE
+"200741_s_at",0.968917934155285,0.853183198760413,-0.187231309979484,-5.92262361776742,-0.0411378232592465,"RPS27","ribosomal protein S27",TRUE
+"244624_at",0.790817398514927,0.320720943172953,1.01573206659021,-5.44929264822209,0.699553106703016,"RPS27A","ribosomal protein S27a",TRUE
+"242214_at",0.940227139261806,0.732149929555132,0.346616162361318,-5.88133518713059,0.11385280579546,"RPS27A","ribosomal protein S27a",TRUE
+"200017_at",0.980001024522674,0.904850484749169,0.120912087156976,-5.93256525564743,0.0260975451728296,"RPS27A","ribosomal protein S27a",TRUE
+"218007_s_at",0.291020678465228,0.00508806268417219,-3.10895742842559,-2.08616895315762,-1.26472083899189,"RPS27L","ribosomal protein S27 like",TRUE
+"222487_s_at",0.475576667310086,0.0262861031296037,-2.38091027099803,-3.50154162044122,-0.935647775039513,"RPS27L","ribosomal protein S27 like",TRUE
+"238935_at",0.56861088242915,0.0582221029719862,-1.99726867890784,-4.16367725009783,-1.17975966274573,"RPS27L","ribosomal protein S27 like",TRUE
+"208902_s_at",0.857287594027564,0.472309936015396,0.731216327210007,-5.6825642781147,0.499047124395814,"RPS28","ribosomal protein S28",TRUE
+"208903_at",0.89316156038085,0.566968348506699,0.581205017298737,-5.77647979680216,0.225098614538924,"RPS28","ribosomal protein S28",TRUE
+"208904_s_at",0.942502815705589,0.74227850278868,0.332981452571942,-5.88582337466501,0.0733926964511937,"RPS28","ribosomal protein S28",TRUE
+"201094_at",0.936992192746977,0.718702513041397,-0.364823153578329,-5.87506445951716,-0.0851280121304274,"RPS29","ribosomal protein S29",TRUE
+"238824_at",0.950372310683766,0.774551260431068,-0.289949216022277,-5.89881856892163,-0.180111880533863,"RPS29","ribosomal protein S29",TRUE
+"207489_at",0.134242602708516,0.000847486847338579,-3.85608071364203,-0.510632396243948,-2.12098283321831,"RPS2P45","ribosomal protein S2 pseudogene 45",TRUE
+"208692_at",0.951023815565189,0.776434098788297,0.287456618764144,-5.89951676412936,0.0674820438819577,"RPS3","ribosomal protein S3",TRUE
+"213347_x_at",0.895366192695711,0.573668861289137,0.571116049696059,-5.78205299701448,0.122803293770819,"RPS4X","ribosomal protein S4, X-linked",TRUE
+"200933_x_at",0.993474831312851,0.969486088980556,-0.038687404761751,-5.93895451220951,-0.00827129050623654,"RPS4X","ribosomal protein S4, X-linked",TRUE
+"201909_at",0.863982129426672,0.490486533747345,0.701185818413799,-5.70300924075919,0.434746194355205,"RPS4Y1","ribosomal protein S4, Y-linked 1",TRUE
+"200024_at",0.939976205834042,0.730018895325475,0.349493342864741,-5.8803653460813,0.0866217650808299,"RPS5","ribosomal protein S5",TRUE
+"211690_at",0.832698390803128,0.409456720009573,0.840773998914081,-5.60112132166015,0.629590777219326,"RPS6","ribosomal protein S6",TRUE
+"200081_s_at",0.909441642299191,0.624086798010922,0.496997060200575,-5.82008678547543,0.115854749585971,"RPS6","ribosomal protein S6",TRUE
+"201254_x_at",0.913299709879835,0.636338432671605,0.4794194318157,-5.82835125334245,0.102751123089838,"RPS6","ribosomal protein S6",TRUE
+"209134_s_at",0.943988850936011,0.749865897761997,0.32280973474629,-5.88905558146345,0.0669713169157937,"RPS6","ribosomal protein S6",TRUE
+"203379_at",0.718958043234793,0.194982227222473,1.33639803490914,-5.10534271366453,0.656118531650307,"RPS6KA1","ribosomal protein S6 kinase A1",TRUE
+"204906_at",0.741877580525799,0.232448895254947,1.22768509033128,-5.23108608481375,0.532788785455523,"RPS6KA2","ribosomal protein S6 kinase A2",TRUE
+"1557970_s_at",0.831875452294783,0.407630367315648,0.844108907558781,-5.59847524756059,0.631469136781984,"RPS6KA2","ribosomal protein S6 kinase A2",TRUE
+"212912_at",0.98539961718117,0.928224095865543,0.0911097199418389,-5.93564118754304,0.130469727489904,"RPS6KA2","ribosomal protein S6 kinase A2",TRUE
+"236658_at",0.937113154905832,0.720373705797733,0.362553737625042,-5.87586336947317,0.163798709304917,"RPS6KA2-AS1","RPS6KA2 antisense RNA 1",TRUE
+"203843_at",0.869971289491322,0.50788614013718,0.6730327529271,-5.72143298030213,0.472569195255829,"RPS6KA3","ribosomal protein S6 kinase A3",TRUE
+"226335_at",0.96287357728432,0.831504815071372,0.215297551507235,-5.91713181113905,0.183482029956718,"RPS6KA3","ribosomal protein S6 kinase A3",TRUE
+"230544_at",0.769258076576208,0.275386910255403,-1.11837333983892,-5.34818191767656,-0.565707580943899,"RPS6KA4","ribosomal protein S6 kinase A4",TRUE
+"204632_at",0.769429807058463,0.276938439380036,1.1146668500706,-5.35198394640516,0.404915937669612,"RPS6KA4","ribosomal protein S6 kinase A4",TRUE
+"204635_at",0.768852835478002,0.272758141663803,-1.12468820304511,-5.34167855253097,-0.520402167313554,"RPS6KA5","ribosomal protein S6 kinase A5",TRUE
+"204633_s_at",0.76912869907427,0.274977217362184,-1.11935460640639,-5.34717348658294,-0.619938891578293,"RPS6KA5","ribosomal protein S6 kinase A5",TRUE
+"1554319_at",0.914562242038395,0.640081176594726,-0.474080316690987,-5.83080392829347,-0.510683961669093,"RPS6KA5","ribosomal protein S6 kinase A5",TRUE
+"228503_at",0.567651250567208,0.0577877798016841,-2.0010240909283,-4.15755647063106,-2.04299146396075,"RPS6KA6","ribosomal protein S6 kinase A6",TRUE
+"220737_at",0.645803111489595,0.117018292752586,1.63102906079185,-4.72091149550801,0.726532648788512,"RPS6KA6","ribosomal protein S6 kinase A6",TRUE
+"220738_s_at",0.872965137259934,0.517376539694026,-0.657905586905509,-5.73103396184377,-0.713896755675284,"RPS6KA6","ribosomal protein S6 kinase A6",TRUE
+"228502_at",0.917102138198416,0.649403398121189,-0.460842082613671,-5.8367692911526,-0.514522400135136,"RPS6KA6","ribosomal protein S6 kinase A6",TRUE
+"211578_s_at",0.815217400146643,0.366255148005526,-0.92240141919787,-5.53356310414009,-0.708985604751611,"RPS6KB1","ribosomal protein S6 kinase B1",TRUE
+"226660_at",0.851124330077654,0.454244315531156,-0.761745627225691,-5.66094617468216,-0.567676922692042,"RPS6KB1","ribosomal protein S6 kinase B1",TRUE
+"204171_at",0.905934790589647,0.612336153702563,-0.514006287151357,-5.81181306597352,-0.436743874988613,"RPS6KB1","ribosomal protein S6 kinase B1",TRUE
+"203777_s_at",0.896328858604647,0.580393444623529,-0.561050681006049,-5.78751890292677,-0.257278694397007,"RPS6KB2","ribosomal protein S6 kinase B2",TRUE
+"218909_at",0.994145854504594,0.973110494483291,-0.0340901751739641,-5.93911746103383,-0.0134880459729114,"RPS6KC1","ribosomal protein S6 kinase C1",TRUE
+"223534_s_at",0.52629147962869,0.0397064902326172,-2.18547862762023,-3.8477835543185,-1.68250888304537,"RPS6KL1","ribosomal protein S6 kinase like 1",TRUE
+"213941_x_at",0.805991582894782,0.346351572750122,0.962162998106569,-5.4985679757606,0.217632878132653,"RPS7","ribosomal protein S7",TRUE
+"200082_s_at",0.816800680706682,0.368027999110899,0.918930781795407,-5.53655326764907,0.216274369640646,"RPS7","ribosomal protein S7",TRUE
+"214089_at",0.391240007651669,0.0131665590137919,2.69534856118166,-2.91128256440471,0.871938664425471,"RPS8","ribosomal protein S8",TRUE
+"214317_x_at",0.942816301320479,0.743734194347549,-0.331027195675056,-5.88645206772972,-0.135370233836186,"RPS9","ribosomal protein S9",TRUE
+"217747_s_at",0.961475152596758,0.825279514494763,0.223389012698956,-5.91540692619354,0.0571779934245971,"RPS9","ribosomal protein S9",TRUE
+"1557981_at",0.961690794738111,0.826315619635823,-0.222041270404159,-5.91569862498849,-0.102283203078468,"RPS9","ribosomal protein S9",TRUE
+"213801_x_at",0.897011777275924,0.58227166298688,0.558249837157701,-5.7890231103691,0.123715199076717,"RPSAP19///RPSAP9///SNORA6///RPSAP58///SNORA62///RPSA","ribosomal protein SA pseudogene 19///ribosomal protein SA pseudogene 9///small nucleolar RNA, H/ACA box 6///ribosomal protein SA pseudogene 58///small nucleolar RNA, H/ACA box 62///ribosomal protein SA",TRUE
+"1553454_at",0.951934441578502,0.780217150197892,-0.282454021457991,-5.90089998215594,-0.165661755020797,"RPTN","repetin",TRUE
+"225715_at",0.797490281058829,0.330869127307517,-0.994180503820888,-5.46940849622009,-0.357573088827452,"RPTOR","regulatory associated protein of MTOR complex 1",TRUE
+"226078_at",0.527546822913581,0.0402546930991397,-2.17885936137674,-3.85919843969496,-0.589354241233858,"RPUSD1","RNA pseudouridylate synthase domain containing 1",TRUE
+"221940_at",0.834881450121645,0.413622165741067,0.833203112373459,-5.60709209379518,0.324189266221556,"RPUSD2","RNA pseudouridylate synthase domain containing 2",TRUE
+"1566602_at",0.73957587762701,0.228137358718018,1.23947736816862,-5.21788800319792,0.340679847706792,"RPUSD3","RNA pseudouridylate synthase domain containing 3",TRUE
+"1561329_s_at",0.784789297644843,0.309240992880724,1.04069425109983,-5.42550622607243,0.618623364559292,"RPUSD3","RNA pseudouridylate synthase domain containing 3",TRUE
+"1566603_s_at",0.997263441064271,0.986045937337622,0.017688167706962,-5.93953109383455,0.00967622066897533,"RPUSD3","RNA pseudouridylate synthase domain containing 3",TRUE
+"225743_at",0.997901456792957,0.990265866314213,-0.0123386411542293,-5.93960932952412,-0.0053345528448201,"RPUSD3","RNA pseudouridylate synthase domain containing 3",TRUE
+"1555916_at",0.998870448604467,0.995648762791992,-0.00551535626816274,-5.93966866471122,-0.00229948644645361,"RPUSD3","RNA pseudouridylate synthase domain containing 3",TRUE
+"225398_at",0.83176405048326,0.406616665892002,-0.845964028342285,-5.59699907532832,-0.352412777158223,"RPUSD4","RNA pseudouridylate synthase domain containing 4",TRUE
+"204803_s_at",0.456633003605056,0.022328982140585,2.45644601282319,-3.36323249123966,2.39778101237416,"RRAD","RRAD, Ras related glycolysis inhibitor and calcium channel regulator",TRUE
+"231100_at",0.710672261019989,0.183784456331404,1.37203833182685,-5.06216413352121,0.650946423820811,"RRAD","RRAD, Ras related glycolysis inhibitor and calcium channel regulator",TRUE
+"204802_at",0.722192678020526,0.19858724275954,1.3252664506122,-5.11863332770715,1.08743248990976,"RRAD","RRAD, Ras related glycolysis inhibitor and calcium channel regulator",TRUE
+"201628_s_at",0.823518986434235,0.390550217359125,-0.875771091401603,-5.57286713628708,-0.326274887483189,"RRAGA","Ras related GTP binding A",TRUE
+"205540_s_at",0.964693183005833,0.836815946877621,-0.208405923702924,-5.91855096754797,-0.0813782842294861,"RRAGB","Ras related GTP binding B",TRUE
+"242531_at",0.767945391174396,0.270565592366022,-1.12998929398022,-5.33619422706118,-0.351412424134536,"RRAGC","Ras related GTP binding C",TRUE
+"222514_at",0.807944276806637,0.349375153785574,-0.956025047004022,-5.50405845838752,-0.311115256128,"RRAGC","Ras related GTP binding C",TRUE
+"218088_s_at",0.862634144901168,0.48599789284751,-0.708540826955211,-5.69807737600712,-0.200789876183842,"RRAGC","Ras related GTP binding C",TRUE
+"221523_s_at",0.84810849097297,0.447748543062364,-0.772900609489968,-5.65283864809616,-0.970432992952929,"RRAGD","Ras related GTP binding D",TRUE
+"221524_s_at",0.909052380289506,0.622657682465277,-0.499057705798277,-5.81909889920532,-0.64552003078624,"RRAGD","Ras related GTP binding D",TRUE
+"212647_at",0.735708712495554,0.220853902115949,1.25978960819664,-5.19489999811364,0.931546834714242,"RRAS","related RAS viral (r-ras) oncogene homolog",TRUE
+"208456_s_at",0.727074488271062,0.207236372236629,1.29918870551183,-5.14940138304464,2.14041571010743,"RRAS2","related RAS viral (r-ras) oncogene homolog 2",TRUE
+"212590_at",0.740476003158683,0.229533684835943,1.23563993628934,-5.22219484699213,1.43184226612117,"RRAS2","related RAS viral (r-ras) oncogene homolog 2",TRUE
+"212589_at",0.780429362666663,0.301931991885606,1.05692955263885,-5.40975673329738,2.02994782919295,"RRAS2","related RAS viral (r-ras) oncogene homolog 2",TRUE
+"201205_at",0.620223198657182,0.0901255584813801,1.77213078840517,-4.51591594580255,0.432859635109305,"RRBP1","ribosome binding protein 1",TRUE
+"213973_at",0.849619613504567,0.450771818813933,0.76769673777863,-5.65663471619221,0.532278722991722,"RRBP1","ribosome binding protein 1",TRUE
+"201203_s_at",0.861659105448003,0.483387086764094,0.712836910831505,-5.69517397863557,0.436922585882714,"RRBP1","ribosome binding protein 1",TRUE
+"227888_at",0.904832003218088,0.610254780405432,0.517035039268163,-5.81031133179393,0.1928262355001,"RRBP1","ribosome binding protein 1",TRUE
+"213495_s_at",0.958770864245184,0.812978718636737,-0.239422735296716,-5.91180194489465,-0.180631464290253,"RRBP1","ribosome binding protein 1",TRUE
+"201204_s_at",0.973071267819624,0.870614378394382,0.164775961965774,-5.92646781836209,0.0852048259441727,"RRBP1","ribosome binding protein 1",TRUE
+"201206_s_at",0.994304286761558,0.974137198592578,0.032788035403932,-5.93915987453155,0.0223385233625137,"RRBP1","ribosome binding protein 1",TRUE
+"216648_s_at",0.580748061056528,0.0634327663154061,-1.9540497935595,-4.23355828763515,-1.07810887823636,"RREB1","ras responsive element binding protein 1",TRUE
+"216649_at",0.733012446828677,0.217550854589647,1.26917053878789,-5.18417523295259,0.773268901674586,"RREB1","ras responsive element binding protein 1",TRUE
+"203704_s_at",0.838245037296515,0.422849084559621,-0.816602562781394,-5.62000716834112,-0.253599614517888,"RREB1","ras responsive element binding protein 1",TRUE
+"215032_at",0.88020017258149,0.535524716896405,0.629398480465249,-5.74855737343474,0.20377063172397,"RREB1","ras responsive element binding protein 1",TRUE
+"217411_s_at",0.950463087620385,0.774660011166705,-0.289805195365844,-5.89885907295674,-0.124781304050261,"RREB1","ras responsive element binding protein 1",TRUE
+"242297_at",0.951006866397403,0.77626313770568,0.28768286876135,-5.89945363656921,0.0818488316932662,"RREB1","ras responsive element binding protein 1",TRUE
+"215620_at",0.973071267819624,0.870294101079491,-0.165187735275534,-5.92640172768926,-0.0729607269894359,"RREB1","ras responsive element binding protein 1",TRUE
+"208314_at",0.700061364939874,0.171575796707886,1.4129121421591,-5.01148465545039,0.532911443118379,"RRH","retinal pigment epithelium-derived rhodopsin homolog",TRUE
+"201477_s_at",0.586395668838578,0.0660661147284485,-1.93338931014427,-4.26659592491551,-0.49436253422745,"RRM1","ribonucleotide reductase catalytic subunit M1",TRUE
+"201476_s_at",0.854184492233394,0.464851618096332,-0.743734474406734,-5.67380139974216,-0.190051409850792,"RRM1","ribonucleotide reductase catalytic subunit M1",TRUE
+"201890_at",0.829485424009328,0.400829560174804,-0.856611706655754,-5.58846797970102,-0.266616034332225,"RRM2","ribonucleotide reductase regulatory subunit M2",TRUE
+"209773_s_at",0.913300726876965,0.636470766901984,0.479230413452431,-5.82843854309007,0.156322420535853,"RRM2","ribonucleotide reductase regulatory subunit M2",TRUE
+"223342_at",0.210925315870036,0.00245356197335789,-3.4165588389254,-1.44695487361745,-1.26912709713728,"RRM2B","ribonucleotide reductase regulatory TP53 inducible subunit M2B",TRUE
+"222204_s_at",0.665347414601538,0.132759459679082,-1.56072456699051,-4.81817404003615,-0.515634641381405,"RRN3","RRN3 homolog, RNA polymerase I transcription factor",TRUE
+"215211_at",0.743474458360704,0.233752877407671,-1.22415134997897,-5.23501989010023,-0.469537523384861,"RRN3P1","RRN3 homolog, RNA polymerase I transcription factor pseudogene 1",TRUE
+"216908_x_at",0.968262726161738,0.85067473551901,-0.190470630737023,-5.92202871994285,-0.0599454630289102,"RRN3P1","RRN3 homolog, RNA polymerase I transcription factor pseudogene 1",TRUE
+"221714_s_at",0.980009054680439,0.906041514100929,-0.11939099244279,-5.93274316498333,-0.0744821970502287,"RRN3P1","RRN3 homolog, RNA polymerase I transcription factor pseudogene 1",TRUE
+"216902_s_at",0.402463840838386,0.0147523065483475,-2.64457081699031,-3.00906260378086,-1.18390420702086,"RRN3P1///RRN3P2///RRN3","RRN3 homolog, RNA polymerase I transcription factor pseudogene 1///RRN3 homolog, RNA polymerase I transcription factor pseudogene 2///RRN3 homolog, RNA polymerase I transcription factor",TRUE
+"243124_at",0.851159202728357,0.454325513734823,0.761606800023912,-5.66104637362865,0.594480499452034,"RRN3P2","RRN3 homolog, RNA polymerase I transcription factor pseudogene 2",TRUE
+"238413_at",0.836756831475262,0.418726910272336,0.823990483041687,-5.61428948613559,0.478873461939675,"RRN3P3","RRN3 homolog, RNA polymerase I transcription factor pseudogene 3",TRUE
+"218914_at",0.776016775539443,0.293388985224981,-1.07626438486596,-5.39071541882237,-0.323085559714615,"RRNAD1","ribosomal RNA adenine dimethylase domain containing 1",TRUE
+"222733_x_at",0.76858139690485,0.271765288205309,1.12708482095646,-5.33920191724933,0.353751559209141,"RRP1","ribosomal RNA processing 1",TRUE
+"218758_s_at",0.782471668844017,0.304775022811251,1.0505816304523,-5.41594078741747,0.307258571871049,"RRP1","ribosomal RNA processing 1",TRUE
+"1559126_at",0.413584432973372,0.0166407923338513,2.59041179169512,-3.11236786587867,1.04138830804563,"RRP12","ribosomal RNA processing 12 homolog",TRUE
+"216909_at",0.58992923389497,0.0680832824120213,-1.91804810181737,-4.29097109533291,-1.1028003773673,"RRP12","ribosomal RNA processing 12 homolog",TRUE
+"1559127_x_at",0.783644735214763,0.306228103981565,1.04735340645586,-5.41907283941486,0.657384439427243,"RRP12","ribosomal RNA processing 12 homolog",TRUE
+"216913_s_at",0.929948792534665,0.690551823994649,0.403356818154799,-5.86074909416408,0.202343527274641,"RRP12","ribosomal RNA processing 12 homolog",TRUE
+"216360_x_at",0.952293443370532,0.781742782236846,0.280438658306275,-5.90145042067235,0.15804905768881,"RRP12","ribosomal RNA processing 12 homolog",TRUE
+"219037_at",0.973605405180651,0.872906025824517,-0.161830488865189,-5.92693577662016,-0.0585041837336302,"RRP15","ribosomal RNA processing 15 homolog",TRUE
+"214764_at",0.979452359556342,0.901094815364724,-0.125710482213634,-5.93198929108568,-0.0597753214279191,"RRP15","ribosomal RNA processing 15 homolog",TRUE
+"212844_at",0.526253358601247,0.0396099765203804,2.18665254741982,-3.8457569068333,0.767922414505605,"RRP1B","ribosomal RNA processing 1B",TRUE
+"212846_at",0.612420348961838,0.0843689296729705,1.80695820577696,-4.46338673632143,0.652062554025051,"RRP1B","ribosomal RNA processing 1B",TRUE
+"225788_at",0.744706562599365,0.236201392466673,-1.21755610190992,-5.24233558017237,-0.38512812941938,"RRP36","ribosomal RNA processing 36",TRUE
+"235223_at",0.861659105448003,0.482546401512814,-0.714223121404993,-5.69423357817828,-0.248236858749866,"RRP36","ribosomal RNA processing 36",TRUE
+"202937_x_at",0.0967947919170275,0.000419576875799461,4.14369787848651,0.10953649225256,1.59683623705622,"RRP7A","ribosomal RNA processing 7 homolog A",TRUE
+"33307_at",0.0985170196189519,0.000440583923003207,4.12375126464875,0.0664466567202915,1.35367194624759,"RRP7A","ribosomal RNA processing 7 homolog A",TRUE
+"229564_at",0.823074246722209,0.389840196526358,-0.877106470430402,-5.57176783076174,-0.517846856325927,"RRP7A","ribosomal RNA processing 7 homolog A",TRUE
+"210584_s_at",0.904832003218088,0.60991262586564,0.517533400660692,-5.81006340742105,0.330482440010494,"RRP7BP///POLDIP3","ribosomal RNA processing 7 homolog B, pseudogene///DNA polymerase delta interacting protein 3",TRUE
+"214828_s_at",0.266375678672809,0.00406054217718424,3.20480670869728,-1.88889714768426,1.40986230954768,"RRP7BP///RRP7A","ribosomal RNA processing 7 homolog B, pseudogene///ribosomal RNA processing 7 homolog A",TRUE
+"202938_x_at",0.301103570046128,0.00574946734573676,3.05671831183868,-2.19284506830569,0.880799939495139,"RRP7BP///RRP7A","ribosomal RNA processing 7 homolog B, pseudogene///ribosomal RNA processing 7 homolog A",TRUE
+"1558963_at",0.700430227058786,0.172151465774412,1.41093358629026,-5.01396614206542,0.934902489538637,"RRP8","ribosomal RNA processing 8, methyltransferase, homolog (yeast)",TRUE
+"203170_at",0.914588178928864,0.640451516839227,0.473552779271701,-5.83104480875515,0.320675573935203,"RRP8","ribosomal RNA processing 8, methyltransferase, homolog (yeast)",TRUE
+"203171_s_at",0.989654520357877,0.950153132524439,0.0632264350229255,-5.93773659346215,0.0191156508532533,"RRP8","ribosomal RNA processing 8, methyltransferase, homolog (yeast)",TRUE
+"204133_at",0.978928101156583,0.897277498219502,-0.130590741328409,-5.93138054659416,-0.0628423347048042,"RRP9","ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)",TRUE
+"209567_at",0.895594830714116,0.574867866189518,-0.569317035237651,-5.78303684964536,-0.304513689211277,"RRS1","ribosome biogenesis regulator homolog",TRUE
+"237729_at",0.760227035076299,0.25799112749792,-1.16101717089522,-5.30363843919993,-0.946649022710994,"RRS1-AS1","RRS1 antisense RNA 1 (head to head)",TRUE
+"207363_at",0.724590981430178,0.201839329471837,1.31535931170523,-5.13038320654026,0.744237741969676,"RS1","retinoschisin 1",TRUE
+"216937_s_at",0.821137675198948,0.382176322282353,-0.891622320581933,-5.55971796649447,-0.664821196073047,"RS1","retinoschisin 1",TRUE
+"218307_at",0.439734782930756,0.0203059152816458,-2.50000785211449,-3.28241610321635,-1.17071521031367,"RSAD1","radical S-adenosyl methionine domain containing 1",TRUE
+"213797_at",0.522667179791589,0.0384270082867149,2.20125605826292,-3.82048961734068,2.11018536650954,"RSAD2","radical S-adenosyl methionine domain containing 2",TRUE
+"242625_at",0.636860247875294,0.107986616098868,1.675028263232,-4.65836494461188,1.54183351505937,"RSAD2","radical S-adenosyl methionine domain containing 2",TRUE
+"213694_at",0.66932922090261,0.135423854532577,-1.54951814615882,-4.83336717042615,-0.583496971553156,"RSBN1","round spermatid basic protein 1",TRUE
+"222791_at",0.701743735478035,0.173282892961846,-1.4070602699047,-5.01881573178026,-0.611760102793506,"RSBN1","round spermatid basic protein 1",TRUE
+"222790_s_at",0.830104575356196,0.401865953067249,-0.854697647644048,-5.59000888685908,-0.333518042846576,"RSBN1","round spermatid basic protein 1",TRUE
+"222789_at",0.896118635245982,0.578279479036631,-0.564208512513408,-5.78581421621648,-0.197251394349852,"RSBN1","round spermatid basic protein 1",TRUE
+"222788_s_at",0.97345342693821,0.871890476402844,-0.163135600392051,-5.92672946742288,-0.070210805366882,"RSBN1","round spermatid basic protein 1",TRUE
+"226387_at",0.697172073261335,0.167516127626333,-1.42701808534203,-4.99371037167505,-0.404930971280578,"RSBN1L","round spermatid basic protein 1 like",TRUE
+"228963_at",0.760227035076299,0.258142822458408,-1.16063627427595,-5.30404279008152,-0.440651318019132,"RSBN1L","round spermatid basic protein 1 like",TRUE
+"232535_at",0.774230543658252,0.288098952489185,-1.08844003373203,-5.37856637055452,-0.403897968476262,"RSBN1L","round spermatid basic protein 1 like",TRUE
+"232221_x_at",0.967954222488353,0.848843184374012,-0.192837132455813,-5.92158768664013,-0.0530493047759588,"RSBN1L","round spermatid basic protein 1 like",TRUE
+"229885_at",0.710824498521146,0.184179121602953,-1.37075345075235,-5.06373725035754,-0.499093958432569,"RSF1","remodeling and spacing factor 1",TRUE
+"222541_at",0.854400503339099,0.46588170059477,0.741998523121986,-5.67502501531399,0.254852375424203,"RSF1","remodeling and spacing factor 1",TRUE
+"235381_at",0.886783047600321,0.550145605294988,-0.606809088113177,-5.76191242005723,-0.265398577264904,"RSF1","remodeling and spacing factor 1",TRUE
+"222540_s_at",0.897037592083216,0.583127756704557,0.556974707126307,-5.78970550562078,0.209881016199734,"RSF1","remodeling and spacing factor 1",TRUE
+"223818_s_at",0.957430653957785,0.807821807232397,-0.246163504260914,-5.91021219637934,-0.204154388970057,"RSF1","remodeling and spacing factor 1",TRUE
+"218166_s_at",0.971867994936839,0.865383025828154,-0.17150550146748,-5.92536708569,-0.0640636223797415,"RSF1","remodeling and spacing factor 1",TRUE
+"220963_s_at",0.817517099085723,0.369954768771916,0.915171417310806,-5.53978046676622,0.240126049326607,"RSG1","REM2 and RAB like small GTPase 1",TRUE
+"244834_at",0.976330538523238,0.885606903757357,0.145531738546722,-5.92937299550287,0.0682933182342058,"RSG1","REM2 and RAB like small GTPase 1",TRUE
+"212019_at",0.56559911410714,0.0565280314154928,-2.01206020469383,-4.13952471642113,-0.842243628627706,"RSL1D1","ribosomal L1 domain containing 1",TRUE
+"213750_at",0.695812999227098,0.165870861950023,-1.43281298711701,-4.98636653896538,-0.625281376146422,"RSL1D1","ribosomal L1 domain containing 1",TRUE
+"212018_s_at",0.846321019035727,0.44436583943327,-0.778748521895005,-5.64854389510721,-0.241449634339011,"RSL1D1","ribosomal L1 domain containing 1",TRUE
+"217915_s_at",0.635663079068274,0.106670484690469,-1.68169715855528,-4.64877438690023,-0.453214922028518,"RSL24D1","ribosomal L24 domain containing 1",TRUE
+"222465_at",0.697172073261335,0.167280402634463,-1.42784553494235,-4.99266324279715,-0.395617582351496,"RSL24D1","ribosomal L24 domain containing 1",TRUE
+"230093_at",0.986889306520757,0.939078957899151,0.077299668552868,-5.93677358126553,0.0908133830759077,"RSPH1","radial spoke head 1 homolog",TRUE
+"1555272_at",0.771527793162888,0.280750261703159,1.10562443282691,-5.36121247650452,0.290431144877605,"RSPH10B2///RSPH10B","radial spoke head 10 homolog B2///radial spoke head 10 homolog B",TRUE
+"1557417_s_at",0.978197434639598,0.894117242521931,0.134633432328602,-5.93085875048045,0.0788169095553704,"RSPH10B2///RSPH10B","radial spoke head 10 homolog B2///radial spoke head 10 homolog B",TRUE
+"229977_at",0.147686070612109,0.00103566629816772,-3.77371417267252,-0.687479497366407,-1.49751175720357,"RSPH14","radial spoke head 14 homolog",TRUE
+"220105_at",0.986342822130003,0.933869102137499,0.0839257934508075,-5.93625341490328,0.0550677717828543,"RSPH14","radial spoke head 14 homolog",TRUE
+"229810_at",0.760227035076299,0.258206054711786,1.16047755099675,-5.304211252625,0.495229141142183,"RSPH3","radial spoke 3 homolog",TRUE
+"223713_at",0.877488742289724,0.527461767981853,0.641997594403248,-5.74090461671143,0.28081552917307,"RSPH3","radial spoke 3 homolog",TRUE
+"1568613_at",0.884122836669679,0.542868851079757,0.618011230845193,-5.75534841026687,0.178876803412843,"RSPH3","radial spoke 3 homolog",TRUE
+"235889_at",0.89316156038085,0.567338042524977,0.580646787936194,-5.77679063511081,0.228124454493693,"RSPH3","radial spoke 3 homolog",TRUE
+"233071_at",0.907801535382949,0.617248536467907,0.506877136344385,-5.81531392703013,0.549718963542794,"RSPH4A","radial spoke head 4 homolog A",TRUE
+"220965_s_at",0.907111393934291,0.615697896643344,0.509124629100213,-5.81421541356096,0.229228915484779,"RSPH6A","radial spoke head 6 homolog A",TRUE
+"230695_s_at",0.672164152353115,0.138003047054205,1.5388421314189,-4.84776071403799,1.03074682069108,"RSPH9","radial spoke head 9 homolog",TRUE
+"241450_at",0.99739139970986,0.986807530215903,-0.0167226759183635,-5.93954727549034,-0.00797785740817147,"RSPO1","R-spondin 1",TRUE
+"242061_at",0.585036027492332,0.0654343109067104,1.93827917618645,-4.25879844364895,1.56949157192871,"RSPO2","R-spondin 2",TRUE
+"1554012_at",0.686108994812404,0.154402124090613,1.4745488220427,-4.9327599038394,1.22153398335455,"RSPO2","R-spondin 2",TRUE
+"228186_s_at",0.212348514754308,0.00252666441092914,3.40429424897737,-1.47275399005169,2.13931204237755,"RSPO3","R-spondin 3",TRUE
+"237423_at",0.951934441578502,0.780237767197465,0.282426778412009,-5.90090744889037,0.279575909725652,"RSPO4","R-spondin 4",TRUE
+"225770_at",0.640067422642767,0.11077074748141,-1.66114438360335,-4.67823855458468,-0.604366874284146,"RSPRY1","ring finger and SPRY domain containing 1",TRUE
+"225774_at",0.699684100574767,0.171150071194256,-1.41437876509391,-5.00964338464732,-0.534383239411556,"RSPRY1","ring finger and SPRY domain containing 1",TRUE
+"225773_at",0.79705794499562,0.330151938532961,-0.995688403736754,-5.46801378570016,-0.332853173122293,"RSPRY1","ring finger and SPRY domain containing 1",TRUE
+"219507_at",0.602806347163336,0.0773052750117013,1.85261934591863,-4.393402184358,0.606661939028774,"RSRC1","arginine and serine rich coiled-coil 1",TRUE
+"1555501_s_at",0.647191158198054,0.118098329864508,1.62596055267895,-4.72803454151523,0.517634509290252,"RSRC1","arginine and serine rich coiled-coil 1",TRUE
+"235354_s_at",0.865540137051525,0.495362749787158,0.693239430941781,-5.7082824858393,0.307497533689587,"RSRC1","arginine and serine rich coiled-coil 1",TRUE
+"202302_s_at",0.714590421965913,0.189974555691284,-1.35213168214941,-5.08639838720374,-0.35628184812632,"RSRC2","arginine and serine rich coiled-coil 2",TRUE
+"202301_s_at",0.960388681678405,0.820318894422069,-0.229847589449161,-5.9139846858415,-0.0625712221203312,"RSRC2","arginine and serine rich coiled-coil 2",TRUE
+"209006_s_at",0.816783744453469,0.367825319724432,0.919326994423702,-5.53621243163298,0.410084928733159,"RSRP1","arginine and serine rich protein 1",TRUE
+"209007_s_at",0.830815768741579,0.404634558054511,0.849599922117873,-5.59409712291549,0.262667084074769,"RSRP1","arginine and serine rich protein 1",TRUE
+"230490_x_at",0.769258076576208,0.275485274607521,1.11813790325013,-5.34842375539799,0.641868418746917,"RSU1","Ras suppressor protein 1",TRUE
+"1560937_at",0.788413816943444,0.314687840713841,1.02877081444012,-5.43693305703794,0.887487905123247,"RSU1","Ras suppressor protein 1",TRUE
+"201980_s_at",0.789595899448337,0.316824720527468,1.02413271276676,-5.44134589043143,0.499733187688465,"RSU1","Ras suppressor protein 1",TRUE
+"215618_at",0.919406408954167,0.657530937902391,0.449368296801437,-5.841805647716,0.303700852840387,"RSU1","Ras suppressor protein 1",TRUE
+"1569543_at",0.932625096890813,0.702434270519102,0.387019249820495,-5.86699142448022,0.303590444164337,"RSU1","Ras suppressor protein 1",TRUE
+"1557672_s_at",0.797612393661522,0.331240731787444,-0.993400088769052,-5.47012957580821,-0.692607794036517,"RSU1P2","Ras suppressor protein 1 pseudogene 2",TRUE
+"1561482_at",0.854400503339099,0.465750160172511,0.742220075158042,-5.67486900140383,0.627818370877523,"RSU1P2","Ras suppressor protein 1 pseudogene 2",TRUE
+"223719_s_at",0.934384170278735,0.709223928578865,-0.377732129946191,-5.87042648985953,-0.31160728186907,"RTBDN","retbindin",TRUE
+"203594_at",0.683838837468118,0.152832293142563,1.48045528275557,-4.92507279590479,0.572618536723995,"RTCA","RNA 3'-terminal phosphate cyclase",TRUE
+"215351_at",0.73223722457785,0.216215732409869,1.27299345756033,-5.1797851700581,0.74925643021384,"RTCA","RNA 3'-terminal phosphate cyclase",TRUE
+"238087_at",0.949038895598021,0.77023510276393,0.29567027938583,-5.8971934471192,0.140168632956223,"RTCA","RNA 3'-terminal phosphate cyclase",TRUE
+"200042_at",0.976371465776674,0.886620540821496,0.144232758148187,-5.92955613997685,0.0533662263037815,"RTCB","RNA 2',3'-cyclic phosphate and 5'-OH ligase",TRUE
+"213829_x_at",0.597654932724127,0.0750419501815056,-1.86801847851236,-4.36951953366433,-0.518218466236588,"RTEL1","regulator of telomere elongation helicase 1",TRUE
+"206092_x_at",0.827832423755003,0.397041603075033,-0.863634666204063,-5.58278668149243,-0.250912770830181,"RTEL1","regulator of telomere elongation helicase 1",TRUE
+"216325_x_at",0.976371465776674,0.886941344275718,-0.143821700138977,-5.92961375409767,-0.0524624775232923,"RTEL1-TNFRSF6B///RTEL1","RTEL1-TNFRSF6B readthrough (NMD candidate)///regulator of telomere elongation helicase 1",TRUE
+"211526_s_at",0.976371465776674,0.887255323204091,-0.143419411231087,-5.929669980245,-0.121508158273433,"RTEL1-TNFRSF6B///RTEL1","RTEL1-TNFRSF6B readthrough (NMD candidate)///regulator of telomere elongation helicase 1",TRUE
+"206467_x_at",0.803583569469174,0.34207451624459,-0.970908168305043,-5.49068984440293,-0.318543299448073,"RTEL1-TNFRSF6B///TNFRSF6B","RTEL1-TNFRSF6B readthrough (NMD candidate)///TNF receptor superfamily member 6b",TRUE
+"212302_at",0.87754354850942,0.52785829398039,0.641375550791119,-5.74128587053767,0.21252781105145,"RTF1","RTF1 homolog, Paf1/RNA polymerase II complex component",TRUE
+"212301_at",0.931370027472813,0.696149168312663,-0.395647199609504,-5.86372649416712,-0.14502695808487,"RTF1","RTF1 homolog, Paf1/RNA polymerase II complex component",TRUE
+"230832_at",0.98416037322447,0.922389054362765,-0.098540659884416,-5.93495507675345,-0.0303902071280149,"RTF1","RTF1 homolog, Paf1/RNA polymerase II complex component",TRUE
+"224128_at",0.763044089435492,0.262815125760248,-1.14898469937625,-5.3163555262887,-0.702359162716149,"RTFDC1","replication termination factor 2 domain containing 1",TRUE
+"217737_x_at",0.778580821633075,0.298839475013189,-1.06388299511786,-5.4029444471346,-0.38963871244834,"RTFDC1","replication termination factor 2 domain containing 1",TRUE
+"234926_s_at",0.796129937317751,0.328309861850998,-0.999571815568877,-5.46441304267936,-0.369926600097786,"RTFDC1","replication termination factor 2 domain containing 1",TRUE
+"233842_x_at",0.818852235468236,0.372578916949696,-0.910072232615058,-5.54413832561243,-0.337173979622287,"RTFDC1","replication termination factor 2 domain containing 1",TRUE
+"236702_at",0.945764550538403,0.75515861396076,0.315734859795105,-5.89124518677851,0.206566359153828,"RTFDC1","replication termination factor 2 domain containing 1",TRUE
+"225151_at",0.689913893405055,0.15908480024863,1.4572150921858,-4.95517566101579,0.707310684827622,"RTKN","rhotekin",TRUE
+"225150_s_at",0.831875452294783,0.407005431846955,0.845252220393023,-5.59756583866458,0.824154136814981,"RTKN","rhotekin",TRUE
+"242047_at",0.56861088242915,0.0581689315284374,1.99772709174674,-4.16293051634611,1.66319194961922,"RTKN2","rhotekin 2",TRUE
+"230469_at",0.835897726578923,0.415602081377621,0.829621449920984,-5.60989917329409,1.05319899047016,"RTKN2","rhotekin 2",TRUE
+"210222_s_at",0.675622576285316,0.142121038849606,-1.52213225816016,-4.87013061772817,-2.09241948485668,"RTN1","reticulon 1",TRUE
+"203485_at",0.812302873476553,0.360404952294635,-0.933934312224066,-5.5235523320789,-1.50838578210336,"RTN1","reticulon 1",TRUE
+"34408_at",0.797334932908547,0.330490186530694,-0.994976950356348,-5.46867207361845,-0.678936777432314,"RTN2","reticulon 2",TRUE
+"204217_s_at",0.885029460971826,0.545920016029176,-0.61330451500294,-5.75812046304848,-0.441362467006424,"RTN2","reticulon 2",TRUE
+"224564_s_at",0.91269009113888,0.633610246450214,-0.48332017419488,-5.82654235342387,-0.153954833991552,"RTN3","reticulon 3",TRUE
+"219549_s_at",0.945966513604392,0.755569165560758,-0.315186758893726,-5.89141281318958,-0.116007798554907,"RTN3","reticulon 3",TRUE
+"1556049_at",0.492341486607851,0.0295874230683198,2.32554392633126,-3.60138444189606,1.06205643903776,"RTN4","reticulon 4",TRUE
+"211509_s_at",0.782148078497692,0.303908673220334,1.05251154526577,-5.41406423106229,0.262099598948616,"RTN4","reticulon 4",TRUE
+"210968_s_at",0.812302873476553,0.359072672235818,0.936578229881082,-5.5212412506148,0.272906972437339,"RTN4","reticulon 4",TRUE
+"214629_x_at",0.92488385924575,0.675051034056898,0.424839370261544,-5.85215449718426,0.117217797556055,"RTN4","reticulon 4",TRUE
+"224509_s_at",0.91876780831279,0.654862924599294,0.453127950511974,-5.84016907862324,0.198466660921083,"RTN4IP1","reticulon 4 interacting protein 1",TRUE
+"1555679_a_at",0.990623482682449,0.952667985772442,0.0600324471266883,-5.93792830894763,0.0196676556071989,"RTN4IP1","reticulon 4 interacting protein 1",TRUE
+"228550_at",0.96635324070119,0.843304293546806,0.200000716490833,-5.92021957434897,0.101890230018938,"RTN4R","reticulon 4 receptor",TRUE
+"230700_at",0.671498069723584,0.137503602628968,-1.5408965574024,-4.8449970303424,-1.03838298422245,"RTN4RL1","reticulon 4 receptor like 1",TRUE
+"229345_at",0.979481436032858,0.901194579600054,0.125582980811864,-5.93200488485308,0.103180582592578,"RTN4RL2","reticulon 4 receptor-like 2",TRUE
+"1553823_a_at",0.844169896707408,0.440665565357458,0.785176627643617,-5.64378783190022,0.305333073051146,"RTP1","receptor transporter protein 1",TRUE
+"1553822_at",0.856257656023992,0.469823507100694,-0.735376511115665,-5.67966774998916,-0.608643739554598,"RTP1","receptor transporter protein 1",TRUE
+"1552569_a_at",0.582980484640151,0.0644965473958371,1.94561427144182,-4.24707638848556,1.2135467523122,"RTP3","receptor transporter protein 3",TRUE
+"1552568_at",0.765419357517701,0.265713970681232,1.14183236740192,-5.32385958792268,0.697886997587807,"RTP3","receptor transporter protein 3",TRUE
+"219684_at",0.289452415034987,0.0049764109763674,3.11841744681041,-2.06678546130332,2.78578617962053,"RTP4","receptor transporter protein 4",TRUE
+"1560035_at",0.949217179291784,0.770849418888606,0.294855393215809,-5.89742684636187,0.0733306165432155,"RTP5","receptor transporter protein 5 (putative)",TRUE
+"1553277_at",0.775351898377291,0.292132748017829,1.07914139155559,-5.38785570593064,0.744435100787972,"RTTN","rotatin",TRUE
+"1557388_at",0.957571530817866,0.808691287122539,0.245026169687525,-5.9104835038443,0.0684026438882999,"RTTN","rotatin",TRUE
+"227072_at",0.982970909614431,0.917439515640136,0.10484835181412,-5.9343305276704,0.0359503758336359,"RTTN","rotatin",TRUE
+"1554612_at",0.690381347688918,0.160167232125512,1.45326715919603,-4.96025100173005,1.10545394047519,"RUBCN","RUN and cysteine rich domain containing beclin 1 interacting protein",TRUE
+"1554613_a_at",0.8485419825626,0.448970663256579,-0.770794453609405,-5.65437794230443,-0.512012922957291,"RUBCN","RUN and cysteine rich domain containing beclin 1 interacting protein",TRUE
+"212733_at",0.920486752529216,0.661404282272731,-0.443921807456303,-5.84415277141691,-0.182799611309047,"RUBCN","RUN and cysteine rich domain containing beclin 1 interacting protein",TRUE
+"212735_at",0.931501755169233,0.697088720887139,0.394355488823162,-5.86421980861632,0.145174296801054,"RUBCN","RUN and cysteine rich domain containing beclin 1 interacting protein",TRUE
+"1560138_at",0.970049339692589,0.858114428231765,-0.180869270943791,-5.92376239638601,-0.107849368519682,"RUBCN","RUN and cysteine rich domain containing beclin 1 interacting protein",TRUE
+"233380_s_at",0.658590024406624,0.126802457259391,-1.58646975071406,-4.78294452523069,-0.452698472663991,"RUFY1","RUN and FYVE domain containing 1",TRUE
+"218243_at",0.767965891104819,0.271116188936538,-1.12865512701891,-5.33757665594749,-0.359195053139716,"RUFY1","RUN and FYVE domain containing 1",TRUE
+"229179_at",0.77547560202111,0.292726349918504,-1.07778083353828,-5.38920893551365,-0.819676995087323,"RUFY1","RUN and FYVE domain containing 1",TRUE
+"233381_at",0.976392182310915,0.887583799638172,-0.142998573173944,-5.92972863070595,-0.0436269181855629,"RUFY1","RUN and FYVE domain containing 1",TRUE
+"235345_at",0.683019114815084,0.151649556321266,1.48493797205428,-4.91922214827228,0.564988764384,"RUFY2","RUN and FYVE domain containing 2",TRUE
+"233191_at",0.692728103625751,0.162197690734719,1.44591926524983,-4.9696673966221,0.512292442934775,"RUFY2","RUN and FYVE domain containing 2",TRUE
+"233192_s_at",0.714590421965913,0.189977293007305,1.35212299316568,-5.08640890053763,0.533763930052589,"RUFY2","RUN and FYVE domain containing 2",TRUE
+"1569630_a_at",0.717967110215679,0.193913494587196,1.33972903593278,-5.10134749052763,1.07951297508952,"RUFY2","RUN and FYVE domain containing 2",TRUE
+"219957_at",0.778974960380281,0.300089822377363,1.06106547694433,-5.40570959486929,0.761766870067295,"RUFY2","RUN and FYVE domain containing 2",TRUE
+"238550_at",0.822178297049143,0.386766089370263,0.882906455335585,-5.56697515749667,0.551889561061937,"RUFY2","RUN and FYVE domain containing 2",TRUE
+"241996_at",0.890943934856426,0.560054298877391,-0.591679759864608,-5.77059357804896,-0.301653894681085,"RUFY2","RUN and FYVE domain containing 2",TRUE
+"1554133_at",0.980832655742,0.910146720115514,0.114150313606432,-5.93333889710941,0.114880962463845,"RUFY2","RUN and FYVE domain containing 2",TRUE
+"213437_at",0.739340500562926,0.226562243366526,1.24382767777863,-5.21299164273632,0.734395846980323,"RUFY3","RUN and FYVE domain containing 3",TRUE
+"210251_s_at",0.774230543658252,0.289355939661184,1.08553245366734,-5.38147867965584,0.500168889861923,"RUFY3","RUN and FYVE domain containing 3",TRUE
+"213430_at",0.792305111661886,0.323284349528437,1.01024392484022,-5.45445228149448,0.44206174240546,"RUFY3","RUN and FYVE domain containing 3",TRUE
+"203724_s_at",0.922168942129244,0.66798760311191,0.434695790016036,-5.84806456212836,0.226288828099838,"RUFY3","RUN and FYVE domain containing 3",TRUE
+"227802_at",0.940227139261806,0.732891180071813,0.345616075291346,-5.88167044083604,0.135355541727675,"RUFY3","RUN and FYVE domain containing 3",TRUE
+"229334_at",0.954577684533304,0.79286123514297,0.265786342356743,-5.90533463408297,0.144319632190657,"RUFY3","RUN and FYVE domain containing 3",TRUE
+"213939_s_at",0.956734254923335,0.803802154583678,0.25142580570217,-5.90894063341077,0.133249829774721,"RUFY3","RUN and FYVE domain containing 3",TRUE
+"235040_at",0.59741849655321,0.0734779830403863,-1.87889780675496,-4.35256250133531,-0.618600122694952,"RUNDC1","RUN domain containing 1",TRUE
+"226298_at",0.751112081216662,0.244120012496024,-1.19657394574187,-5.2653817718932,-0.401598316413414,"RUNDC1","RUN domain containing 1",TRUE
+"213439_x_at",0.686998148149102,0.155547388677896,1.47027047313294,-4.93831255620581,1.11890740125316,"RUNDC3A","RUN domain containing 3A",TRUE
+"206196_s_at",0.969882914559333,0.857327615987276,0.181883859839093,-5.92358341891174,0.141685606075092,"RUNDC3A","RUN domain containing 3A",TRUE
+"1557644_at",0.812302873476553,0.356816693737572,-0.941070305416178,-5.51730091654169,-0.958864304888801,"RUNDC3A-AS1","RUNDC3A antisense RNA 1",TRUE
+"241703_at",0.54295328972902,0.0459936715681466,-2.11406585442958,-3.96978894024175,-1.70998118128106,"RUNDC3B","RUN domain containing 3B",TRUE
+"215321_at",0.710672261019989,0.183897414703444,-1.37167035916596,-5.06261477833662,-1.42192307571919,"RUNDC3B","RUN domain containing 3B",TRUE
+"220918_at",0.0475276319818049,5.99800019523464e-05,4.938637092996,1.82008211929626,3.76924786338857,"RUNX1-IT1","RUNX1 intronic transcript 1",TRUE
+"228827_at",0.560467295493135,0.0543309367737325,2.03184246908447,-4.1070377469354,1.32156699711734,"RUNX1T1","RUNX1 translocation partner 1",TRUE
+"205528_s_at",0.819203514175924,0.375929659807872,-0.903595594562073,-5.54964097497549,-0.879079751644461,"RUNX1T1","RUNX1 translocation partner 1",TRUE
+"216831_s_at",0.851319596585235,0.455059318776995,0.760352866995742,-5.66195062117161,0.250859865994211,"RUNX1T1","RUNX1 translocation partner 1",TRUE
+"216832_at",0.8877101263145,0.552821118937272,0.602709966738534,-5.76428538699637,0.306793293476993,"RUNX1T1","RUNX1 translocation partner 1",TRUE
+"205529_s_at",0.960664106415106,0.821308149992111,-0.228558819420234,-5.91427170633299,-0.236789457530305,"RUNX1T1","RUNX1 translocation partner 1",TRUE
+"1564642_at",0.977369242833284,0.891687635476528,0.137743015796502,-5.93044658759005,0.0418125098618516,"RUNX1T1","RUNX1 translocation partner 1",TRUE
+"242845_at",0.99514093116831,0.977761663471277,-0.028191678132957,-5.93929638465035,-0.0225785359033477,"RUNX1T1","RUNX1 translocation partner 1",TRUE
+"232231_at",0.631316839203356,0.102459129990578,1.70351547836322,-4.61719656794903,2.12700362047195,"RUNX2","runt related transcription factor 2",TRUE
+"221283_at",0.752269883717571,0.245597026508617,1.1927170876561,-5.2695801495934,0.82367851194983,"RUNX2","runt related transcription factor 2",TRUE
+"216994_s_at",0.756795789115566,0.252222594140975,1.17562659189069,-5.28804173532937,0.784688494792422,"RUNX2","runt related transcription factor 2",TRUE
+"221282_x_at",0.776936981479994,0.295252642698342,1.07201250497998,-5.39492924650615,0.617001028121662,"RUNX2","runt related transcription factor 2",TRUE
+"236859_at",0.81035488031479,0.354187735368563,-0.946329251284526,-5.51266592410686,-0.753074048848481,"RUNX2","runt related transcription factor 2",TRUE
+"236858_s_at",0.960455930163982,0.8204438489502,0.229684780829031,-5.91402103337218,0.144593234449469,"RUNX2","runt related transcription factor 2",TRUE
+"204198_s_at",0.238811487311851,0.00316668181620652,3.30967613655563,-1.67099275544519,4.09576458034491,"RUNX3","runt related transcription factor 3",TRUE
+"204197_s_at",0.255716413540338,0.00368322561454937,3.24603334614738,-1.80347719613794,1.73611669482397,"RUNX3","runt related transcription factor 3",TRUE
+"234928_x_at",0.919375181609246,0.657302714599663,0.449689641678507,-5.84166628956777,0.293968562782569,"RUNX3","runt related transcription factor 3",TRUE
+"206949_s_at",0.852371612067119,0.458093095827615,-0.755181584541144,-5.66566489139415,-0.332412397347568,"RUSC1","RUN and SH3 domain containing 1",TRUE
+"1552862_at",0.822850703882235,0.388186111480772,-0.8802235527896,-5.5691957497658,-0.580397875139982,"RUSC1-AS1","RUSC1 antisense RNA 1",TRUE
+"230256_at",0.904381089098038,0.607766762610128,-0.52066196924008,-5.80850169369716,-0.262450064888215,"RUSC1-AS1","RUSC1 antisense RNA 1",TRUE
+"213066_at",0.961212424803935,0.823454007531321,0.225764622714118,-5.91488848358091,0.169975807559399,"RUSC2","RUN and SH3 domain containing 2",TRUE
+"201614_s_at",0.839519981963042,0.428130681549223,-0.807202242481075,-5.62721247014771,-0.368434757375663,"RUVBL1","RuvB like AAA ATPase 1",TRUE
+"1559945_at",0.846615322073696,0.444999439340535,0.777651115972752,-5.64935216621334,0.311372992016034,"RUVBL2","RuvB like AAA ATPase 2",TRUE
+"1559946_s_at",0.907189812622248,0.616094271838235,-0.508549871722207,-5.8144967904903,-0.161772803700721,"RUVBL2","RuvB like AAA ATPase 2",TRUE
+"201459_at",0.924509228034459,0.67391523151922,-0.426421377018184,-5.85150424995293,-0.151565152487263,"RUVBL2","RuvB like AAA ATPase 2",TRUE
+"240214_at",0.789795896476304,0.318047297696306,-1.02148896639615,-5.4438531738834,-0.740786820397074,"RWDD1","RWD domain containing 1",TRUE
+"219598_s_at",0.982909728377256,0.917185229904534,-0.105172529027438,-5.93429738408851,-0.0356680251691337,"RWDD1","RWD domain containing 1",TRUE
+"229786_at",0.768852835478002,0.273066959809717,1.12394405752131,-5.34244659491164,0.31348744118263,"RWDD2A","RWD domain containing 2A",TRUE
+"213555_at",0.812302873476553,0.359888742960224,-0.934957952886734,-5.52265826705829,-0.324063538156921,"RWDD2A","RWD domain containing 2A",TRUE
+"222614_at",0.708473702007515,0.180539080187198,1.38268778202972,-5.04907857167335,0.544393239817955,"RWDD2B","RWD domain containing 2B",TRUE
+"218377_s_at",0.9112290256956,0.629185517659996,0.489662864313403,-5.82357045252547,0.194081462490319,"RWDD2B","RWD domain containing 2B",TRUE
+"205087_at",0.877333806479767,0.527073805833838,-0.642606450400286,-5.74053110171358,-0.292073081125888,"RWDD3","RWD domain containing 3",TRUE
+"225574_at",0.840872144163754,0.430242611514259,-0.803463595425951,-5.6300563574401,-0.398170659367926,"RWDD4","RWD domain containing 4",TRUE
+"238206_at",0.584247456664678,0.064857933599447,-1.94277648031593,-4.25161500343646,-1.6117073057223,"RXFP1","relaxin/insulin like family peptide receptor 1",TRUE
+"1552715_a_at",0.919958860702745,0.659308056658004,0.446867703387155,-5.8428867456312,0.287976339846156,"RXFP1","relaxin/insulin like family peptide receptor 1",TRUE
+"231804_at",0.937462538530338,0.722780529208403,0.359288765379623,-5.87700411266719,0.310855731857394,"RXFP1","relaxin/insulin like family peptide receptor 1",TRUE
+"1553326_at",0.867159108376357,0.499217834791525,0.686988667324816,-5.71239018910272,0.426237653619103,"RXFP2","relaxin/insulin like family peptide receptor 2",TRUE
+"221066_at",0.697699759202153,0.168235857511371,1.4244974353202,-4.99689716245979,0.555270950498749,"RXFP3","relaxin/insulin like family peptide receptor 3",TRUE
+"202449_s_at",0.774230543658252,0.288087380797035,-1.08846684302747,-5.37853948534615,-0.572063573268561,"RXRA","retinoid X receptor alpha",TRUE
+"202426_s_at",0.97070558355376,0.860314437495948,-0.178033401663667,-5.92425736138153,-0.0765148452685249,"RXRA","retinoid X receptor alpha",TRUE
+"215099_s_at",0.578925607036084,0.0618685381236733,1.96668344605585,-4.21323801223623,0.637175427399674,"RXRB","retinoid X receptor beta",TRUE
+"209148_at",0.820611742812032,0.381223441798626,0.893440396996875,-5.55819583872475,0.343113326546529,"RXRB","retinoid X receptor beta",TRUE
+"215098_at",0.949761528403753,0.772563111697453,0.292583266386838,-5.89807425388701,0.195880347551141,"RXRB","retinoid X receptor beta",TRUE
+"205954_at",0.886023097762234,0.548561072220284,-0.609241678647201,-5.76049686315406,-0.263776563428121,"RXRG","retinoid X receptor gamma",TRUE
+"201845_s_at",0.329541287798136,0.00786903603132417,-2.92143729831709,-2.46604183559388,-1.08706711959727,"RYBP","RING1 and YY1 binding protein",TRUE
+"201844_s_at",0.636860247875294,0.107877346392606,-1.67557931169756,-4.65757357446651,-0.761248281535169,"RYBP","RING1 and YY1 binding protein",TRUE
+"242719_at",0.734320804572117,0.218664417361475,-1.2659957880056,-5.18781239202721,-0.668402319603809,"RYBP","RING1 and YY1 binding protein",TRUE
+"201846_s_at",0.807528762746328,0.348742370211719,-0.95730661976756,-5.5029147288177,-0.346315741707253,"RYBP","RING1 and YY1 binding protein",TRUE
+"214172_x_at",0.587626678796111,0.0666896389181384,1.9286037201576,-4.2742139878715,0.577835709078149,"RYK","receptor-like tyrosine kinase",TRUE
+"216976_s_at",0.641112145892678,0.11162551576504,1.65694094858124,-4.68423058512936,0.517257564466032,"RYK","receptor-like tyrosine kinase",TRUE
+"202853_s_at",0.724970327905974,0.202786464094821,1.31249737898353,-5.13376360403233,0.385215888445341,"RYK","receptor-like tyrosine kinase",TRUE
+"205485_at",0.56861088242915,0.0585503471580028,1.99444694988555,-4.16827118642144,2.33344223111728,"RYR1","ryanodine receptor 1",TRUE
+"207557_s_at",0.0925545494931958,0.000367422347541014,4.19787394334834,0.226595372018617,3.26438629529105,"RYR2","ryanodine receptor 2",TRUE
+"214044_at",0.687734660055697,0.157071587502629,1.46461599448341,-4.9456311816702,1.44851997163739,"RYR2","ryanodine receptor 2",TRUE
+"206306_at",0.955051304714495,0.794848583834872,-0.263173684049575,-5.90600548903308,-0.140375087716738,"RYR3","ryanodine receptor 3",TRUE
+"205334_at",0.753862100951903,0.247251020892789,-1.18841866726308,-5.27424528074708,-1.08156399500086,"S100A1","S100 calcium binding protein A1",TRUE
+"238909_at",0.51531387545335,0.0357989917648767,2.23521829287008,-3.76133174540193,1.3308128128936,"S100A10","S100 calcium binding protein A10",TRUE
+"200872_at",0.680160698079016,0.147406160338878,1.50125891663958,-4.89780048659097,0.85429230075755,"S100A10","S100 calcium binding protein A10",TRUE
+"200660_at",0.633326968581968,0.104532373583656,1.69268115075368,-4.63291551349303,0.572534763725622,"S100A11","S100 calcium binding protein A11",TRUE
+"205863_at",0.622434989367596,0.0930566349990148,1.75512792759329,-4.54128890995898,1.08922542014744,"S100A12","S100 calcium binding protein A12",TRUE
+"202598_at",0.891444650197327,0.561118228015559,-0.590063587887202,-5.7715084101485,-0.321947286172204,"S100A13","S100 calcium binding protein A13",TRUE
+"213481_at",0.957571530817866,0.809055568766784,-0.244549764574036,-5.91059677752601,-0.0835514533556312,"S100A13","S100 calcium binding protein A13",TRUE
+"218677_at",0.90466378569832,0.608892329557445,0.519020290935667,-5.8093223275022,0.71442278997859,"S100A14","S100 calcium binding protein A14",TRUE
+"227998_at",0.865854896594418,0.49615321010549,0.691955499863602,-5.70912912326572,0.649386759133089,"S100A16","S100 calcium binding protein A16",TRUE
+"204268_at",0.354266150238033,0.00947423975628002,2.84055452195148,-2.62707076415874,4.56741283992337,"S100A2","S100 calcium binding protein A2",TRUE
+"206027_at",0.553930058946379,0.0506076463388682,2.06705666349697,-4.04869073138557,2.12822226582842,"S100A3","S100 calcium binding protein A3",TRUE
+"203186_s_at",0.7768734672127,0.294811805785171,1.07301652154547,-5.39393556035436,1.93240066530683,"S100A4","S100 calcium binding protein A4",TRUE
+"207763_at",0.498396792791655,0.0311986142780353,2.30055772679549,-3.64600094505104,1.9248732243164,"S100A5","S100 calcium binding protein A5",TRUE
+"217728_at",0.687402616985184,0.156012420195138,1.46854055386549,-4.94055402502877,2.66075182417696,"S100A6","S100 calcium binding protein A6",TRUE
+"228923_at",0.7974001826642,0.330631032846128,0.994680850020466,-5.46894592101245,1.19592451348659,"S100A6","S100 calcium binding protein A6",TRUE
+"205916_at",0.921729477898827,0.666332051704527,-0.437012280166788,-5.84708996269253,-0.644840385187874,"S100A7","S100 calcium binding protein A7",TRUE
+"232170_at",0.710672261019989,0.183893565405699,-1.37168289567574,-5.06259942691286,-1.01941829546072,"S100A7A","S100 calcium binding protein A7A",TRUE
+"232220_at",0.872319806242276,0.515462428899414,0.660944063949209,-5.72912227372879,0.240713986462578,"S100A7A","S100 calcium binding protein A7A",TRUE
+"202917_s_at",0.952181675930279,0.781111157363052,-0.281272891726372,-5.90122304825215,-0.523947231367018,"S100A8","S100 calcium binding protein A8",TRUE
+"214370_at",0.993225426079816,0.968364900395755,-0.0401096991038617,-5.9388999298266,-0.0660922045032053,"S100A8","S100 calcium binding protein A8",TRUE
+"203535_at",0.763044089435492,0.262766073798577,1.14910622477953,-5.31622766844686,2.27093832041632,"S100A9","S100 calcium binding protein A9",TRUE
+"1561521_at",0.973048241540182,0.869434398609283,-0.166293180115164,-5.92622348727872,-0.158002844179818,"S100B","S100 calcium binding protein B",TRUE
+"209686_at",0.986361618040699,0.9357606470732,-0.081519613766032,-5.93644724658994,-0.0961330177623183,"S100B","S100 calcium binding protein B",TRUE
+"207885_at",0.95877806139143,0.813172707893835,0.239169388717815,-5.91186083856829,0.125859532326519,"S100G","S100 calcium binding protein G",TRUE
+"204351_at",0.781196073006007,0.302903415824688,1.05475579864228,-5.41187813810369,1.82221679605189,"S100P","S100 calcium binding protein P",TRUE
+"218370_s_at",0.714090776972967,0.189169176189944,-1.35469246750604,-5.0832974745041,-0.38044187727653,"S100PBP","S100P binding protein",TRUE
+"222610_s_at",0.983212176432519,0.918265013426521,0.10379604171816,-5.93443741050102,0.0256207984240433,"S100PBP","S100P binding protein",TRUE
+"1554876_a_at",0.536559328842429,0.0434039598545119,-2.14234337098351,-3.92178245708749,-1.32295165220718,"S100Z","S100 calcium binding protein Z",TRUE
+"204642_at",0.627092759817312,0.0984925203559531,1.72477452145082,-4.58613469238977,1.60771447630536,"S1PR1","sphingosine-1-phosphate receptor 1",TRUE
+"227684_at",0.582010371816891,0.0642100880255965,1.94787367695309,-4.24345956783387,0.722201130082844,"S1PR2","sphingosine-1-phosphate receptor 2",TRUE
+"208537_at",0.98539961718117,0.928734400967904,-0.0904601011767125,-5.93569861439195,-0.0294290757425606,"S1PR2","sphingosine-1-phosphate receptor 2",TRUE
+"228176_at",0.432151440378733,0.0192904118102237,-2.52342162363269,-3.2386716971458,-2.02731299087613,"S1PR3","sphingosine-1-phosphate receptor 3",TRUE
+"231741_at",0.62282585384278,0.0933178758688738,-1.7536349025617,-4.54350831507753,-1.74289262278613,"S1PR3","sphingosine-1-phosphate receptor 3",TRUE
+"206437_at",0.861962516141708,0.484506843461941,0.710992708150432,-5.69642238284684,0.355218459483344,"S1PR4","sphingosine-1-phosphate receptor 4",TRUE
+"221417_x_at",0.58935212773312,0.0678165817334679,1.9200533352491,-4.28779267074936,1.34917223769212,"S1PR5","sphingosine-1-phosphate receptor 5",TRUE
+"233743_x_at",0.683017520100356,0.151529736042113,1.48539368783236,-4.91862656601252,0.621881196219353,"S1PR5","sphingosine-1-phosphate receptor 5",TRUE
+"230464_at",0.843321606335254,0.437879416227737,0.790038569952444,-5.64016608853192,1.08036566057133,"S1PR5","sphingosine-1-phosphate receptor 5",TRUE
+"208607_s_at",0.438531512553085,0.0201181266692066,2.50425404216534,-3.2744985980472,2.58553524374558,"SAA2-SAA4///SAA2///SAA1","SAA2-SAA4 readthrough///serum amyloid A2///serum amyloid A1",TRUE
+"207096_at",0.593339168375633,0.0704929794803275,1.90023648579657,-4.31910233931713,0.591887128255908,"SAA2-SAA4///SAA4","SAA2-SAA4 readthrough///serum amyloid A4, constitutive",TRUE
+"214456_x_at",0.384135218769668,0.0124667596593223,2.7196194902626,-2.86424067009574,3.12451712242072,"SAA2///SAA1","serum amyloid A2///serum amyloid A1",TRUE
+"222226_at",0.986342822130003,0.934237667721234,0.0834569124460447,-5.93629162796913,0.0515660660726245,"SAA3P","serum amyloid A3 pseudogene",TRUE
+"225614_at",0.899808883319249,0.592003774438498,0.54380844362544,-5.79666292155748,0.207488211970293,"SAAL1","serum amyloid A like 1",TRUE
+"205449_at",0.844974084282113,0.442007400872577,-0.78284179387808,-5.64551960326628,-0.314423081176969,"SAC3D1","SAC3 domain containing 1",TRUE
+"202797_at",0.726636642789909,0.206352104804862,-1.30181555671677,-5.14632550946174,-0.532174899708185,"SACM1L","SAC1 suppressor of actin mutations 1-like (yeast)",TRUE
+"213262_at",0.737488397392592,0.223611026359367,1.25204112915226,-5.20370704408514,1.30778796318664,"SACS","sacsin molecular chaperone",TRUE
+"1560940_at",0.853278202305152,0.459808513036696,0.752266627340033,-5.66774798600377,0.687404843408334,"SACS-AS1","SACS antisense RNA 1",TRUE
+"1560941_a_at",0.87754354850942,0.527805113563613,0.641458961902142,-5.74123476804534,0.222902899739201,"SACS-AS1","SACS antisense RNA 1",TRUE
+"217946_s_at",0.653206225743412,0.122493583234408,-1.60572624362633,-4.75630017109506,-0.521018434587171,"SAE1","SUMO1 activating enzyme subunit 1",TRUE
+"241185_at",0.75959865506602,0.257429237593208,1.1624294894502,-5.3021381395445,0.624943990298344,"SAE1","SUMO1 activating enzyme subunit 1",TRUE
+"1555618_s_at",0.884769004468037,0.544687885778886,-0.615203508319671,-5.75700449648733,-0.212543046884862,"SAE1","SUMO1 activating enzyme subunit 1",TRUE
+"213635_s_at",0.96200396340887,0.827460272898061,-0.2205528198726,-5.91601873643552,-0.0870325301001751,"SAFB","scaffold attachment factor B",TRUE
+"201747_s_at",0.977369242833284,0.891652159275699,-0.137788430982958,-5.93044049838776,-0.0440117226220078,"SAFB","scaffold attachment factor B",TRUE
+"201748_s_at",0.98529096111871,0.926829850380652,0.092884801125898,-5.93548217505993,0.0237662002222052,"SAFB","scaffold attachment factor B",TRUE
+"32099_at",0.683019114815084,0.152194272991169,-1.48286992244807,-4.92192306511814,-0.418474441256709,"SAFB2","scaffold attachment factor B2",TRUE
+"203280_at",0.823074246722209,0.389436333062658,0.877866746144492,-5.57114126503111,0.345309903012247,"SAFB2","scaffold attachment factor B2",TRUE
+"206671_at",0.90427866743639,0.606779762560718,0.522102736026888,-5.80777941049398,0.414435746382969,"SAG","S-antigen visual arrestin",TRUE
+"220793_at",0.856545578149517,0.470498246267543,0.734246285710206,-5.68045621271628,0.744434602376569,"SAGE1","sarcoma antigen 1",TRUE
+"229273_at",0.789503009592599,0.316369860114569,1.02511814497274,-5.44040982594532,1.27950931622592,"SALL1","spalt like transcription factor 1",TRUE
+"206893_at",0.804658857755908,0.343651709176793,0.96767469161561,-5.49361032359496,0.91642550679286,"SALL1","spalt like transcription factor 1",TRUE
+"213283_s_at",0.94943075115007,0.771286526479124,-0.294275697086772,-5.897592493766,-0.195196055513316,"SALL2","spalt like transcription factor 2",TRUE
+"1553411_s_at",0.563430805981458,0.0556818890822396,2.01959631245064,-4.12717360220378,1.41854529929706,"SALL3","spalt like transcription factor 3",TRUE
+"230785_at",0.769258076576208,0.275590611029776,1.11788584687487,-5.34868261479492,0.790885012405893,"SALL3","spalt like transcription factor 3",TRUE
+"232847_at",0.954723352940649,0.793860352002042,0.264472623129539,-5.90567278189712,0.190444454875933,"SALL3","spalt like transcription factor 3",TRUE
+"243672_at",0.986342822130003,0.934089334557241,0.0836456163138165,-5.93627627462535,0.0601236025594414,"SALL3","spalt like transcription factor 3",TRUE
+"229661_at",0.538375019104427,0.0438771531929348,2.13706490786357,-3.93077425715262,1.94247337944372,"SALL4","spalt like transcription factor 4",TRUE
+"228276_at",0.861659105448003,0.48340623083379,0.712805360370474,-5.6951953621155,0.46794577029528,"SAMD1","sterile alpha motif domain containing 1",TRUE
+"225650_at",0.982070099379003,0.913886503636109,0.109378983332982,-5.93385805285119,0.0359198490680992,"SAMD1","sterile alpha motif domain containing 1",TRUE
+"227773_at",0.948762694803494,0.766888313381722,-0.300113380950607,-5.89590962184345,-0.0966593033944099,"SAMD10","sterile alpha motif domain containing 10",TRUE
+"233001_at",0.971469873887034,0.864175285429951,-0.173060262917595,-5.925106530209,-0.0792299392741276,"SAMD10","sterile alpha motif domain containing 10",TRUE
+"1560477_a_at",0.642613985059507,0.113122049344941,-1.6496464446415,-4.69460145148354,-1.00858417558362,"SAMD11","sterile alpha motif domain containing 11",TRUE
+"1562637_at",0.521380653791828,0.0378674453810214,2.20830645407672,-3.80825403504774,1.67639713083522,"SAMD12","sterile alpha motif domain containing 12",TRUE
+"238673_at",0.937462538530338,0.722873633744929,0.359162544724571,-5.87704800808514,0.522685296592266,"SAMD12","sterile alpha motif domain containing 12",TRUE
+"229402_at",0.726480797733202,0.205451484887219,1.3044999805681,-5.14317678276009,1.25727377940454,"SAMD13","sterile alpha motif domain containing 13",TRUE
+"1559995_at",0.65284137151906,0.122134233375724,1.60735758334027,-4.75403148392352,0.54927769314168,"SAMD14","sterile alpha motif domain containing 14",TRUE
+"1555819_s_at",0.788959978568497,0.31522324155151,-1.02760665521699,-5.43804236602346,-0.492616372877252,"SAMD14","sterile alpha motif domain containing 14",TRUE
+"213866_at",0.804658857755908,0.343616280549178,0.96774721410271,-5.4935449187322,0.710797877840633,"SAMD14","sterile alpha motif domain containing 14",TRUE
+"1559996_s_at",0.960116489822537,0.819375040167918,0.231077583256369,-5.9137092578613,0.188982879097243,"SAMD14","sterile alpha motif domain containing 14",TRUE
+"1559997_x_at",0.97897951922649,0.897854469476587,0.12985290549444,-5.93147406647021,0.0656661911553131,"SAMD14","sterile alpha motif domain containing 14",TRUE
+"1557680_at",0.857316604145187,0.472445824144314,-0.730989337550228,-5.68272187079029,-0.471846405144174,"SAMD15","sterile alpha motif domain containing 15",TRUE
+"232316_at",0.907189812622248,0.616155845808044,0.508460602969857,-5.81454046488799,0.270825268813489,"SAMD15","sterile alpha motif domain containing 15",TRUE
+"1557681_s_at",0.927058918776758,0.681427345179711,0.415978393191786,-5.85575267353375,0.222195494216541,"SAMD15","sterile alpha motif domain containing 15",TRUE
+"236782_at",0.869082033398093,0.505743387457981,0.676469996196117,-5.71922228078864,0.557518622959327,"SAMD3","sterile alpha motif domain containing 3",TRUE
+"1553876_at",0.969882914559333,0.856690413236457,0.182705671502295,-5.92343771654121,0.140755514852567,"SAMD3","sterile alpha motif domain containing 3",TRUE
+"215495_s_at",0.764312283028184,0.264346507033616,1.14519911376158,-5.32033241322951,1.13770635619629,"SAMD4A","sterile alpha motif domain containing 4A",TRUE
+"215120_s_at",0.769258076576208,0.276360111413847,1.11604665992294,-5.35056987685147,1.22510571920831,"SAMD4A","sterile alpha motif domain containing 4A",TRUE
+"212845_at",0.857148066512338,0.472030316109262,0.731683529686394,-5.68223976605952,0.749436654427825,"SAMD4A","sterile alpha motif domain containing 4A",TRUE
+"215496_at",0.995726813849707,0.979518366399753,0.0259641493324064,-5.93935513878117,0.0227684851960257,"SAMD4A","sterile alpha motif domain containing 4A",TRUE
+"220457_at",0.376193411416669,0.011483617808037,2.75599001321699,-2.79339020478765,1.42102444906806,"SAMD4B","sterile alpha motif domain containing 4B",TRUE
+"226714_at",0.499983604958508,0.0317181943066179,2.29275217654376,-3.65988144722811,0.579932114088466,"SAMD4B","sterile alpha motif domain containing 4B",TRUE
+"227511_at",0.622434989367596,0.0928559069155707,1.75627755801338,-4.53957901755628,0.482165616754973,"SAMD4B","sterile alpha motif domain containing 4B",TRUE
+"229871_at",0.710524994175401,0.183456448884758,1.37310786293005,-5.0608537408004,0.540914248784187,"SAMD4B","sterile alpha motif domain containing 4B",TRUE
+"1569433_at",0.744573608322482,0.235890256432385,1.2183912919503,-5.24141104749312,1.17103766482998,"SAMD5","sterile alpha motif domain containing 5",TRUE
+"242626_at",0.812302873476553,0.358475012555111,0.937766429980232,-5.52020067568601,1.25929440847068,"SAMD5","sterile alpha motif domain containing 5",TRUE
+"228653_at",0.833526995214835,0.411023709519655,0.837920216535418,-5.60337787997303,1.05154825659753,"SAMD5","sterile alpha motif domain containing 5",TRUE
+"225950_at",0.923708852928185,0.672279841973575,-0.428701181440337,-5.85056301230423,-0.178436933025965,"SAMD8","sterile alpha motif domain containing 8",TRUE
+"242062_at",0.941345931827527,0.737671718351907,0.339174798256969,-5.88380676445232,0.117903750650007,"SAMD8","sterile alpha motif domain containing 8",TRUE
+"228531_at",0.161251584505959,0.00127408659362733,3.68839196732196,-0.870127063001226,3.77935693244874,"SAMD9","sterile alpha motif domain containing 9",TRUE
+"219691_at",0.287796329902695,0.00490265329714345,3.12477982668096,-2.05373800255893,3.15542345016025,"SAMD9","sterile alpha motif domain containing 9",TRUE
+"226603_at",0.299420079118957,0.00552757013892336,3.07356772684413,-2.15850530188444,2.03979893166532,"SAMD9L","sterile alpha motif domain containing 9 like",TRUE
+"235643_at",0.327864702134751,0.00773804174654715,2.92871811679621,-2.45145798277821,2.7938895725637,"SAMD9L","sterile alpha motif domain containing 9 like",TRUE
+"230036_at",0.345823377376834,0.00880682332856122,2.87246398421635,-2.56376192313137,3.08343060964855,"SAMD9L","sterile alpha motif domain containing 9 like",TRUE
+"235964_x_at",0.513069117279725,0.0344298233433802,2.25382222020641,-3.72869490960357,1.094507314371,"SAMHD1","SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",TRUE
+"1559883_s_at",0.527826453640453,0.0404207857106165,2.17686999812441,-3.86262490198132,1.35031018485482,"SAMHD1","SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",TRUE
+"204502_at",0.577452268836288,0.0615392590357751,1.96937882282199,-4.20889117792692,1.44997781114527,"SAMHD1","SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",TRUE
+"234987_at",0.621733119678766,0.0920795803374639,1.76074397783605,-4.53292810456476,1.06519045049123,"SAMHD1","SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",TRUE
+"235529_x_at",0.622753941247615,0.0932393920997343,1.75408307037002,-4.54284225289419,0.953245539727737,"SAMHD1","SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",TRUE
+"1559882_at",0.751464513744428,0.244701860131793,1.1950525102009,-5.26703933723281,1.00018653317342,"SAMHD1","SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",TRUE
+"230396_at",0.705559553212919,0.177523436881504,1.39272044474762,-5.03667416225596,0.411397600116458,"SAMM50","SAMM50 sorting and assembly machinery component",TRUE
+"243239_at",0.881970070870254,0.539170193222828,0.6237357021061,-5.75194942205047,0.263969852620642,"SAMM50","SAMM50 sorting and assembly machinery component",TRUE
+"201570_at",0.908425207680517,0.61933288959716,-0.503860240638854,-5.81678104980578,-0.142803762172964,"SAMM50","SAMM50 sorting and assembly machinery component",TRUE
+"201569_s_at",0.937113154905832,0.720919252127143,-0.361813326941455,-5.87612295373939,-0.098179216495506,"SAMM50","SAMM50 sorting and assembly machinery component",TRUE
+"1569544_at",0.865187396415238,0.494414331714665,0.694781474614383,-5.70726366611983,0.561644939204117,"SAMMSON","survival associated mitochondrial melanoma specific oncogenic non-coding RNA",TRUE
+"1569599_at",0.560923390313819,0.054499505065608,2.03029970997404,-4.10957887934287,1.90964080241429,"SAMSN1","SAM domain, SH3 domain and nuclear localization signals 1",TRUE
+"1555638_a_at",0.65284137151906,0.121789272602186,-1.60892737647664,-4.75184670258579,-1.12102240632084,"SAMSN1","SAM domain, SH3 domain and nuclear localization signals 1",TRUE
+"220330_s_at",0.711902920992134,0.185465690614716,1.36657993332331,-5.06883854134912,1.35657093354186,"SAMSN1","SAM domain, SH3 domain and nuclear localization signals 1",TRUE
+"220367_s_at",0.98427503418599,0.92358932517381,0.0970116616235906,-5.93510064113924,0.022973652873624,"SAP130","Sin3A associated protein 130",TRUE
+"208742_s_at",0.346950498371304,0.00894988881902112,-2.86543432182313,-2.57773388334378,-0.847505355972274,"SAP18","Sin3A associated protein 18",TRUE
+"208740_at",0.358427723880268,0.0101832753111085,-2.80891979496005,-2.68954191184959,-1.42072313177993,"SAP18","Sin3A associated protein 18",TRUE
+"208741_at",0.527826453640453,0.0403673308521846,-2.17750944083147,-3.86152374251439,-1.16511973785351,"SAP18","Sin3A associated protein 18",TRUE
+"37796_at",0.789378278298554,0.315813151015595,-1.0263255806905,-5.43926177155711,-0.323678646568707,"SAP25///LRCH4","Sin3A associated protein 25///leucine rich repeats and calponin homology domain containing 4",TRUE
+"204692_at",0.957430653957785,0.807856836180502,0.246117677779599,-5.91022315228854,0.0675239953500402,"SAP25///LRCH4","Sin3A associated protein 25///leucine rich repeats and calponin homology domain containing 4",TRUE
+"204900_x_at",0.308621629697291,0.00636012271629051,-3.01339150379149,-2.2808390045277,-1.2755770977961,"SAP30","Sin3A associated protein 30",TRUE
+"213963_s_at",0.369429132228615,0.0110164674298277,-2.7743183099488,-2.75752773754236,-1.06390250241067,"SAP30","Sin3A associated protein 30",TRUE
+"204899_s_at",0.597879550155311,0.0753470308262637,-1.8659193641215,-4.37278330910887,-0.684940637060762,"SAP30","Sin3A associated protein 30",TRUE
+"204898_at",0.958587459575795,0.812214350932131,-0.240421142263603,-5.91156924866489,-0.117711815906183,"SAP30","Sin3A associated protein 30",TRUE
+"222475_at",0.897949253801113,0.586327963149632,0.552216312803325,-5.7922386223027,0.167343986545117,"SAP30BP","SAP30 binding protein",TRUE
+"217965_s_at",0.971216837324271,0.863042375376984,0.174519089875678,-5.9248599199295,0.0798950945675738,"SAP30BP","SAP30 binding protein",TRUE
+"219129_s_at",0.744173203410763,0.235004929677005,-1.22077236244198,-5.23877225632117,-0.396069038066598,"SAP30L","SAP30 like",TRUE
+"225509_at",0.904381089098038,0.607932193092363,-0.520420592427272,-5.80862251023042,-0.204311682001835,"SAP30L","SAP30 like",TRUE
+"239802_at",0.915569510513076,0.64414603282638,0.468297491068316,-5.83343010867382,0.316706739880398,"SAP30L","SAP30 like",TRUE
+"232135_at",0.926263798296325,0.679715385413363,0.418354101050124,-5.85479528559363,0.180237764026552,"SAP30L","SAP30 like",TRUE
+"226772_s_at",0.977432261688948,0.891854424712176,-0.137529502988975,-5.93047518822408,-0.0897224692636538,"SAP30L","SAP30 like",TRUE
+"222831_at",0.993223654424259,0.967736817896463,0.0409064959402085,-5.93886849070895,0.0131254412499251,"SAP30L","SAP30 like",TRUE
+"225777_at",0.595453032706696,0.0721299808257792,-1.88843840822124,-4.33763507663856,-0.796081426702022,"SAPCD2","suppressor APC domain containing 2",TRUE
+"201542_at",0.919372089675945,0.657105121542873,-0.449967897149579,-5.8415455391489,-0.182454003930971,"SAR1A","secretion associated Ras related GTPase 1A",TRUE
+"201543_s_at",0.956398858120188,0.802243138384947,0.253468727499127,-5.90843978601699,0.0838860972607574,"SAR1A","secretion associated Ras related GTPase 1A",TRUE
+"210790_s_at",0.993892931327222,0.971227278474771,-0.0364787634487598,-5.93903536653661,-0.0262916874319465,"SAR1A","secretion associated Ras related GTPase 1A",TRUE
+"218254_s_at",0.343271130430125,0.00861395502423651,-2.88211518376971,-2.54455675448346,-0.967200704421947,"SAR1B","secretion associated Ras related GTPase 1B",TRUE
+"230397_at",0.39149295959037,0.0132428679803045,-2.69277607122792,-2.91625717268463,-1.48420301126274,"SAR1B","secretion associated Ras related GTPase 1B",TRUE
+"223512_at",0.415590231477955,0.0168661024936823,-2.58434024078735,-3.12388358778411,-0.801265766143885,"SAR1B","secretion associated Ras related GTPase 1B",TRUE
+"1554482_a_at",0.492240113206751,0.0295299052824535,-2.3264588037698,-3.59974551800924,-0.854354964813862,"SAR1B","secretion associated Ras related GTPase 1B",TRUE
+"226742_at",0.51531387545335,0.0359784451075401,-2.23282818035364,-3.76551293719225,-0.977049614204597,"SAR1B","secretion associated Ras related GTPase 1B",TRUE
+"200847_s_at",0.829044392052913,0.40032192033999,-0.857550398949424,-5.5877111151163,-0.291461120888579,"SARAF","store-operated calcium entry associated regulatory factor",TRUE
+"231258_at",0.98529096111871,0.926861083167023,0.0928450338325319,-5.93548577100024,0.049191583488529,"SARAF","store-operated calcium entry associated regulatory factor",TRUE
+"234536_at",0.564004192185035,0.0559417558283991,2.0172710492989,-4.13098781044096,1.01984004317798,"SARDH","sarcosine dehydrogenase",TRUE
+"234586_at",0.725143559947316,0.203286119319506,1.31099177464384,-5.13553946394283,0.804215753982538,"SARDH","sarcosine dehydrogenase",TRUE
+"211322_s_at",0.958833323462396,0.813796765943989,0.23835448825507,-5.91204985216188,0.104168440756001,"SARDH","sarcosine dehydrogenase",TRUE
+"207889_at",0.98539961718117,0.9282067728832,-0.0911317728142532,-5.93563923084454,-0.0802538044566723,"SARDH","sarcosine dehydrogenase",TRUE
+"210862_s_at",0.986342822130003,0.934493901834217,0.0831309483627403,-5.93631806746375,0.0626373061318324,"SARDH","sarcosine dehydrogenase",TRUE
+"210063_at",0.989586772349659,0.949514696066974,0.0640373868075708,-5.93768633600648,0.0585697003264496,"SARDH","sarcosine dehydrogenase",TRUE
+"213257_at",0.797508506396963,0.33107294814091,-0.993752380051547,-5.46980413316788,-0.324383922524663,"SARM1","sterile alpha and TIR motif containing 1",TRUE
+"234060_at",0.90344422113846,0.604310580095794,-0.525712024106541,-5.80596147323359,-0.250770594698785,"SARM1","sterile alpha and TIR motif containing 1",TRUE
+"213259_s_at",0.997529192253754,0.987444534322166,0.0159151412203598,-5.93956011244404,0.0130501119503297,"SARM1","sterile alpha and TIR motif containing 1",TRUE
+"224914_s_at",0.462049949204478,0.0232786674621933,-2.43724872150003,-3.39860646567224,-0.775278614380206,"SARNP","SAP domain containing ribonucleoprotein",TRUE
+"229069_at",0.70215456577829,0.173616201528003,-1.40592307806278,-5.02023746849846,-0.500259424143627,"SARNP","SAP domain containing ribonucleoprotein",TRUE
+"200802_at",0.720021194788968,0.196127583977908,-1.33284406190616,-5.10959615749793,-0.50770486777748,"SARS","seryl-tRNA synthetase",TRUE
+"231894_at",0.854184492233394,0.464710644810618,-0.743972228058158,-5.67363360389283,-0.395419854933152,"SARS","seryl-tRNA synthetase",TRUE
+"218702_at",0.748184017928985,0.240542435185965,1.20598907280263,-5.25508346881938,0.352071271426372,"SARS2","seryl-tRNA synthetase 2, mitochondrial",TRUE
+"200051_at",0.860026478479837,0.478610437324298,-0.720731911864493,-5.68979479400396,-0.232442534909799,"SART1","squamous cell carcinoma antigen recognized by T-cells 1",TRUE
+"231998_at",0.925511384407886,0.677928378757963,-0.420836567161185,-5.85378914771675,-0.217467394239049,"SART1","squamous cell carcinoma antigen recognized by T-cells 1",TRUE
+"209128_s_at",0.893699016160898,0.56918860796991,-0.577855270195479,-5.77834069468703,-0.159250941956211,"SART3","squamous cell carcinoma antigen recognized by T-cells 3",TRUE
+"209127_s_at",0.925511384407886,0.677754284416463,-0.421078558336053,-5.85369075621129,-0.152496720702993,"SART3","squamous cell carcinoma antigen recognized by T-cells 3",TRUE
+"200069_at",0.9340157600858,0.707546027570628,-0.380024041613651,-5.86958641718986,-0.125325574402126,"SART3","squamous cell carcinoma antigen recognized by T-cells 3",TRUE
+"1554276_at",0.971867994936839,0.865365063143057,0.171528622206387,-5.92536322816388,0.122387801780089,"SART3","squamous cell carcinoma antigen recognized by T-cells 3",TRUE
+"41644_at",0.774230543658252,0.288037284865465,1.08858291423178,-5.37842307866689,0.700530740809757,"SASH1","SAM and SH3 domain containing 1",TRUE
+"213236_at",0.797963285726587,0.332153303442438,0.991486140142375,-5.47189582698425,0.673537624450162,"SASH1","SAM and SH3 domain containing 1",TRUE
+"226022_at",0.933867546984507,0.707091883128754,0.38064473164248,-5.86935804833361,0.267955848537616,"SASH1","SAM and SH3 domain containing 1",TRUE
+"204923_at",0.968066640321622,0.849773724087145,-0.191634665269802,-5.92181246268198,-0.0554991669528313,"SASH3","SAM and SH3 domain containing 3",TRUE
+"231895_at",0.959357995170594,0.816257595805192,0.235142716940347,-5.91278856451172,0.0866323356635661,"SASS6","SAS-6 centriolar assembly protein",TRUE
+"203455_s_at",0.792013951867008,0.322835540940414,1.01120260752996,-5.45355280782868,0.704627598945473,"SAT1","spermidine/spermine N1-acetyltransferase 1",TRUE
+"210592_s_at",0.801560848966415,0.33854620001857,0.97817884095515,-5.48409050981694,0.749534149965491,"SAT1","spermidine/spermine N1-acetyltransferase 1",TRUE
+"213988_s_at",0.867341891633858,0.499639693075446,0.686306320920552,-5.7128364429705,0.608742749223788,"SAT1","spermidine/spermine N1-acetyltransferase 1",TRUE
+"225272_at",0.915639438262336,0.644363012038019,0.467989264747649,-5.83356919918597,0.162008790926363,"SAT2","spermidine/spermine N1-acetyltransferase family member 2",TRUE
+"203408_s_at",0.778397054392363,0.298190651425892,1.06534836155626,-5.40150372131361,1.68406233447163,"SATB1","SATB homeobox 1",TRUE
+"244267_at",0.783215903203604,0.305718992032543,1.04848323205735,-5.41797765777805,1.00185710493076,"SATB1","SATB homeobox 1",TRUE
+"241365_at",0.963120895816356,0.83234277968432,-0.214209523806763,-5.91735891842915,-0.393630012648873,"SATB1","SATB homeobox 1",TRUE
+"241634_at",0.778028733502341,0.29735141134458,1.06724716338472,-5.39963420704461,0.286218152094986,"SATB1-AS1","SATB1 antisense RNA 1",TRUE
+"213435_at",0.811940320844951,0.356095417531616,-0.942510532800237,-5.51603392255036,-1.0298196834209,"SATB2","SATB homeobox 2",TRUE
+"215591_at",0.850493643619556,0.45315608634094,-0.763607653462213,-5.65960058310238,-0.612538268392961,"SATB2","SATB homeobox 2",TRUE
+"1560010_a_at",0.255533790235106,0.00365381680883571,3.2494167275551,-1.79645260567122,1.59813971514031,"SATB2-AS1","SATB2 antisense RNA 1",TRUE
+"1553420_at",0.975398143273847,0.881034004911359,-0.151395151687805,-5.92852591646647,-0.120144021126847,"SATB2-AS1","SATB2 antisense RNA 1",TRUE
+"222573_s_at",0.556314028408939,0.0516280357680589,2.05718160373647,-4.06511912749805,0.809260071114172,"SAV1","salvador family WW domain containing protein 1",TRUE
+"234491_s_at",0.812302873476553,0.358321076596253,0.938072683827713,-5.51993227526585,0.350361054002841,"SAV1","salvador family WW domain containing protein 1",TRUE
+"218276_s_at",0.870582088525756,0.509786120644547,0.669991745195063,-5.72337984918605,0.256550319137869,"SAV1","salvador family WW domain containing protein 1",TRUE
+"238729_x_at",0.885312914741353,0.546622623713654,-0.612222653715513,-5.75875474443097,-0.23207204358426,"SAV1","salvador family WW domain containing protein 1",TRUE
+"240421_x_at",0.956734254923335,0.804056225822063,0.251092976715017,-5.90902184891822,0.110414970710629,"SAV1","salvador family WW domain containing protein 1",TRUE
+"231570_at",0.980009054680439,0.905357015507708,-0.120265147990812,-5.93264119741654,-0.0727809574338973,"SAXO1","stabilizer of axonemal microtubules 1",TRUE
+"1556158_at",0.973071267819624,0.86982547872343,0.165790285165036,-5.92630472037547,0.212012524812969,"SAXO2","stabilizer of axonemal microtubules 2",TRUE
+"218784_s_at",0.622592910022613,0.0931355722190207,-1.75467641277529,-4.54196024071138,-0.871601271552095,"SAYSD1","SAYSVFN motif domain containing 1",TRUE
+"222741_s_at",0.732088067718098,0.21581701829868,-1.2741386347835,-5.17846790704255,-0.470974846737171,"SAYSD1","SAYSVFN motif domain containing 1",TRUE
+"232992_at",0.983567332578112,0.919941707842157,-0.101659029965826,-5.93465115165881,-0.0503667308143418,"SAYSD1","SAYSVFN motif domain containing 1",TRUE
+"1554089_s_at",0.654826820947014,0.123742415929722,-1.60008780968859,-4.76412770803003,-0.456293793210914,"SBDSP1///SBDS","Shwachman-Bodian-Diamond syndrome pseudogene 1///SBDS ribosome assembly guanine nucleotide exchange factor",TRUE
+"222669_s_at",0.769258076576208,0.276357478277241,-1.11605294702846,-5.35056343009432,-0.341686168152025,"SBDSP1///SBDS","Shwachman-Bodian-Diamond syndrome pseudogene 1///SBDS ribosome assembly guanine nucleotide exchange factor",TRUE
+"222084_s_at",0.51470556386048,0.0352002665498632,2.24327237388426,-3.74722238392351,1.53346683547493,"SBF1","SET binding factor 1",TRUE
+"212389_at",0.728385463227073,0.209550993387123,1.29235367134644,-5.15738005821114,1.09451147878179,"SBF1","SET binding factor 1",TRUE
+"39835_at",0.769258076576208,0.276186914024622,1.11646029407582,-5.35014567050753,0.425398987804032,"SBF1","SET binding factor 1",TRUE
+"213383_at",0.841813886364358,0.434056525426089,0.79674073574386,-5.63513903912141,0.247351848054441,"SBF1","SET binding factor 1",TRUE
+"212393_at",0.888686718625571,0.555072451097572,0.599268781048156,-5.76626548565289,0.310518525469117,"SBF1","SET binding factor 1",TRUE
+"233914_s_at",0.483342512055348,0.0276966088755264,2.35651298359129,-3.54570148793339,1.22290270316818,"SBF2","SET binding factor 2",TRUE
+"226169_at",0.877857073443889,0.529106993636998,0.639418334650883,-5.7424831415374,0.296324283983463,"SBF2","SET binding factor 2",TRUE
+"242935_at",0.929088231432081,0.687582259941517,-0.40745710036446,-5.85914255365097,-0.362429260638156,"SBF2","SET binding factor 2",TRUE
+"1566831_at",0.800179799309599,0.335801283898706,0.983871219318999,-5.47889242605347,0.556944797503419,"SBF2-AS1","SBF2 antisense RNA 1",TRUE
+"242786_at",0.908801761853008,0.62103461492955,0.50140067104636,-5.81797081955821,0.344251808910749,"SBF2-AS1","SBF2 antisense RNA 1",TRUE
+"226549_at",0.54295328972902,0.0462290185892617,-2.11156765398912,-3.97401062825836,-1.80443622967596,"SBK1","SH3 domain binding kinase 1",TRUE
+"226548_at",0.699120404996448,0.170458088177237,-1.41676888548188,-5.00663934488196,-1.5046508240861,"SBK1","SH3 domain binding kinase 1",TRUE
+"218737_at",0.659870891937597,0.127655377324731,-1.58272278698073,-4.78809989673641,-0.439765324494495,"SBNO1","strawberry notch homolog 1",TRUE
+"216162_at",0.778291838199375,0.297787738566579,1.06625948509308,-5.40060702317771,0.83589536020237,"SBNO1","strawberry notch homolog 1",TRUE
+"216161_at",0.817815704063733,0.370339692394575,0.914421944066133,-5.54042238845598,0.672473292390857,"SBNO1","strawberry notch homolog 1",TRUE
+"229528_at",0.896159990898752,0.579343670045296,0.562618106565987,-5.78667392220268,0.215694366751957,"SBNO1","strawberry notch homolog 1",TRUE
+"230407_at",0.97928472590149,0.899900135103137,-0.127237482479228,-5.93180130711099,-0.0346588591625672,"SBNO1","strawberry notch homolog 1",TRUE
+"204166_at",0.91202803207519,0.631340833058798,-0.486570768609419,-5.82502400121074,-0.208810473096596,"SBNO2","strawberry notch homolog 2",TRUE
+"215760_s_at",0.952237574337645,0.781220819433991,0.281128038356611,-5.90126257648881,0.0854591667286044,"SBNO2","strawberry notch homolog 2",TRUE
+"235272_at",0.861275718491431,0.481495264954899,0.715958321461268,-5.69305397377876,0.317631471920505,"SBSN","suprabasin",TRUE
+"214725_at",0.736094223891156,0.221320933142811,1.2584718989928,-5.19640101448679,1.24130169418146,"SBSPON","somatomedin B and thrombospondin type 1 domain containing",TRUE
+"235209_at",0.812896635201594,0.361855874437795,0.931062396128896,-5.5260559064668,0.876921311002492,"SBSPON","somatomedin B and thrombospondin type 1 domain containing",TRUE
+"235210_s_at",0.822850703882235,0.388416026536471,0.879789767063868,-5.56955419801886,0.356076846346148,"SBSPON","somatomedin B and thrombospondin type 1 domain containing",TRUE
+"215064_at",0.957208446914964,0.806346313171957,-0.248094304226586,-5.90974875020537,-0.170886693813412,"SC5D","sterol-C5-desaturase",TRUE
+"211423_s_at",0.987915939622712,0.942292021057602,-0.0732149392847109,-5.93707295145774,-0.0295534643679289,"SC5D","sterol-C5-desaturase",TRUE
+"225500_x_at",0.984925919649162,0.925839371565957,0.0941460129307844,-5.93536733235468,0.0385917624441312,"SCAF1","SR-related CTD associated factor 1",TRUE
+"225336_at",0.728385463227073,0.209384901611341,-1.29284218475456,-5.15681099241188,-0.442020332677918,"SCAF11","SR-related CTD associated factor 11",TRUE
+"206989_s_at",0.774230543658252,0.286426551676627,-1.09232273240445,-5.37466653341567,-0.361791203080257,"SCAF11","SR-related CTD associated factor 11",TRUE
+"235579_at",0.785435091542984,0.310896844354281,-1.03705395429656,-5.42900748821328,-0.409067346321043,"SCAF11","SR-related CTD associated factor 11",TRUE
+"209376_x_at",0.912421110187259,0.633166476465292,-0.483955391782502,-5.82624642555008,-0.167488213296899,"SCAF11","SR-related CTD associated factor 11",TRUE
+"1570507_at",0.915353407558177,0.643066113172696,0.469832239317067,-5.83273620205923,0.236069774380512,"SCAF11","SR-related CTD associated factor 11",TRUE
+"232597_x_at",0.948988685362499,0.769842631112706,-0.296190997355467,-5.89704396888028,-0.0978121664667917,"SCAF11","SR-related CTD associated factor 11",TRUE
+"213850_s_at",0.969882914559333,0.856139854952229,-0.183415839953299,-5.92331128049825,-0.0627141111538148,"SCAF11","SR-related CTD associated factor 11",TRUE
+"243759_at",0.76912869907427,0.274953138138186,1.11941231238725,-5.34711415874266,0.491644326792865,"SCAF4","SR-related CTD associated factor 4",TRUE
+"233753_at",0.801917957653237,0.339687606753525,0.975821129280969,-5.48623544089231,0.678695789630467,"SCAF4","SR-related CTD associated factor 4",TRUE
+"222310_at",0.806697551763868,0.347909067591989,0.958996713755655,-5.50140427448999,0.489566208578678,"SCAF4","SR-related CTD associated factor 4",TRUE
+"226082_s_at",0.835952408568777,0.416685083659217,0.827666859032158,-5.6114262859252,0.262523719880862,"SCAF4","SR-related CTD associated factor 4",TRUE
+"222311_s_at",0.837368340567858,0.421280199628644,0.819409030447463,-5.61784086145037,0.262471725778797,"SCAF4","SR-related CTD associated factor 4",TRUE
+"203250_at",0.680708651141727,0.148675079724032,-1.49633867246048,-4.90427823757746,-0.384521708328561,"SCAF8","SR-related CTD associated factor 8",TRUE
+"228174_at",0.832605695407954,0.409129955670891,-0.841369972325533,-5.60064916590244,-0.317546241851085,"SCAI","suppressor of cancer cell invasion",TRUE
+"241754_at",0.876632890672003,0.525488774956503,0.645096494275628,-5.73899999368172,0.245294658110597,"SCAI","suppressor of cancer cell invasion",TRUE
+"214997_at",0.943512938262733,0.74755765682308,0.325900454398032,-5.88808395753775,0.175354509613616,"SCAI","suppressor of cancer cell invasion",TRUE
+"212416_at",0.87579870142401,0.523427208213852,-0.64834131771658,-5.73699624325098,-0.204149650126544,"SCAMP1","secretory carrier membrane protein 1",TRUE
+"1552978_a_at",0.878110025868144,0.529955422416745,-0.638089937593201,-5.74329374658364,-0.259462448270076,"SCAMP1","secretory carrier membrane protein 1",TRUE
+"206667_s_at",0.954577684533304,0.792189709610855,-0.266669586624869,-5.90510635383982,-0.122851020152304,"SCAMP1","secretory carrier membrane protein 1",TRUE
+"212417_at",0.955730092376044,0.797420657946114,-0.259795092935961,-5.90686325224749,-0.104835085989443,"SCAMP1","secretory carrier membrane protein 1",TRUE
+"212425_at",0.955816406528307,0.798882453507646,-0.257876305603241,-5.90734549514582,-0.100775938459916,"SCAMP1","secretory carrier membrane protein 1",TRUE
+"206668_s_at",0.959356077764139,0.81566460685863,-0.235916428566227,-5.91261152102226,-0.0998709242826266,"SCAMP1","secretory carrier membrane protein 1",TRUE
+"238039_at",0.634202341398092,0.105084038992783,-1.68982900968088,-4.63704097216499,-0.952305457436746,"SCAMP1-AS1","SCAMP1 antisense RNA 1",TRUE
+"224921_at",0.620912785033482,0.0908007600828677,-1.7681723623994,-4.52183905251431,-0.730335345982988,"SCAMP2","secretory carrier membrane protein 2",TRUE
+"218143_s_at",0.76912869907427,0.275030795722441,-1.11922621882569,-5.34730547285606,-0.384244936796266,"SCAMP2","secretory carrier membrane protein 2",TRUE
+"201771_at",0.68033297785336,0.147783718259581,-1.49979133078249,-4.8997344228392,-0.497388623223781,"SCAMP3","secretory carrier membrane protein 3",TRUE
+"235073_at",0.86376638668979,0.489387164872972,0.702983627208864,-5.70180825877763,0.317235733171021,"SCAMP4","secretory carrier membrane protein 4",TRUE
+"213244_at",0.940646172990697,0.73417713372117,-0.343881932124013,-5.88224949818637,-0.111571014350398,"SCAMP4","secretory carrier membrane protein 4",TRUE
+"234568_at",0.693742297578797,0.162930671006697,1.44328495597934,-4.97303381931868,0.742868689137033,"SCAMP5","secretory carrier membrane protein 5",TRUE
+"212699_at",0.945534735950946,0.754518163540005,-0.316590080918235,-5.89098305721014,-0.153481399628316,"SCAMP5","secretory carrier membrane protein 5",TRUE
+"234241_at",0.986455005400648,0.93698025595966,-0.079968446876109,-5.93656921510459,-0.0263703304927629,"SCAMP5","secretory carrier membrane protein 5",TRUE
+"1555722_at",0.989669132517581,0.950479026307251,0.0628124965239565,-5.93776199983472,0.0208642653087763,"SCAMPER","sphingolipid Ca2+ release mediating protein of endoplasmic reticulum",TRUE
+"232652_x_at",0.0228644521109842,1.75639138301113e-05,-5.44676940237095,2.8905141210374,-1.8406081245713,"SCAND1","SCAN domain containing 1",TRUE
+"218206_x_at",0.101433355715822,0.000467511762970042,-4.09952440893602,0.0141196003445536,-1.36404977384091,"SCAND1","SCAN domain containing 1",TRUE
+"231059_x_at",0.212348514754308,0.00252786779317815,-3.40409526645273,-1.47317237256968,-1.26336285195005,"SCAND1","SCAN domain containing 1",TRUE
+"215670_s_at",0.541849190341655,0.0453024533892468,-2.12147019453992,-3.95725774508766,-1.299356930337,"SCAND2P","SCAN domain containing 2 pseudogene",TRUE
+"206021_at",0.734913444725244,0.219949655432886,1.262346985403,-5.19198302374474,0.609505379925126,"SCAND2P","SCAN domain containing 2 pseudogene",TRUE
+"222211_x_at",0.903021267024792,0.602897133397396,-0.527781290307215,-5.80491371929266,-0.446580231940043,"SCAND2P","SCAN domain containing 2 pseudogene",TRUE
+"230612_at",0.932023157973583,0.699514657114208,0.391023424970899,-5.86548501202825,0.290386368184242,"SCAND2P","SCAN domain containing 2 pseudogene",TRUE
+"222177_s_at",0.97928472590149,0.899316786332602,0.127983211694404,-5.93170867927056,0.0922277534642415,"SCAND2P","SCAN domain containing 2 pseudogene",TRUE
+"233242_at",0.982648419247268,0.915826529484829,0.106904870391854,-5.93411853868189,0.0682879390816868,"SCAND2P","SCAN domain containing 2 pseudogene",TRUE
+"212329_at",0.501012247664528,0.0320537876969459,-2.28777264239794,-3.66872207041352,-0.751310138594176,"SCAP","SREBF chaperone",TRUE
+"215848_at",0.741816732763138,0.232374854723992,1.22788618770149,-5.23086192614095,0.344906679276461,"SCAPER","S-phase cyclin A associated protein in the ER",TRUE
+"209741_x_at",0.954014881715784,0.788831347701445,-0.271090043171162,-5.90395255674288,-0.100956714722622,"SCAPER","S-phase cyclin A associated protein in the ER",TRUE
+"216399_s_at",0.975398143273847,0.88167831856154,-0.150568682644184,-5.92864733635654,-0.0523092460278338,"SCAPER","S-phase cyclin A associated protein in the ER",TRUE
+"219416_at",0.729083413548563,0.210987917237964,1.28813981079418,-5.16228116470763,0.826716293603293,"SCARA3","scavenger receptor class A member 3",TRUE
+"223843_at",0.797612393661522,0.331188408202894,0.993509938101765,-5.47002810950628,1.18009366707601,"SCARA3","scavenger receptor class A member 3",TRUE
+"223842_s_at",0.986356978750617,0.935549679864586,-0.0817879543610583,-5.93642590934217,-0.0691468783521518,"SCARA3","scavenger receptor class A member 3",TRUE
+"229839_at",0.277557544433551,0.00446224200378768,3.16481049223196,-1.97144768017087,2.79183129220921,"SCARA5","scavenger receptor class A member 5",TRUE
+"235849_at",0.662855903464759,0.130673399818719,1.56962912035433,-4.80604025773355,0.98978651102596,"SCARA5","scavenger receptor class A member 5",TRUE
+"1554705_at",0.950980582261399,0.776212353810324,-0.287750079151795,-5.89943487424577,-0.152180616283718,"SCARA5","scavenger receptor class A member 5",TRUE
+"232421_at",0.940044918888428,0.730801666424768,0.348436149292726,-5.8807226261437,0.189166163114198,"SCARB1","scavenger receptor class B member 1",TRUE
+"1552256_a_at",0.943919772060845,0.748746902806247,0.324307659264719,-5.88858582619267,0.23630636211699,"SCARB1","scavenger receptor class B member 1",TRUE
+"201819_at",0.960693014177181,0.821414051354373,0.228420878055681,-5.91430233196408,0.161995601298541,"SCARB1","scavenger receptor class B member 1",TRUE
+"215835_at",0.975242094553739,0.879799191862191,-0.152979363870388,-5.9282913195511,-0.104099996190248,"SCARB1","scavenger receptor class B member 1",TRUE
+"215834_x_at",0.991754150288374,0.961788391600191,-0.0484541973868415,-5.93854001412625,-0.0326242534586862,"SCARB1","scavenger receptor class B member 1",TRUE
+"215754_at",0.765228531154075,0.265195976740034,1.14310618335245,-5.32252614898803,0.337568632092209,"SCARB2","scavenger receptor class B member 2",TRUE
+"224983_at",0.779854829728531,0.301244334775795,-1.05847133077256,-5.40824970973819,-0.486141345926693,"SCARB2","scavenger receptor class B member 2",TRUE
+"201646_at",0.816800680706682,0.368566216327208,-0.91787933925545,-5.537457099077,-0.460150680293646,"SCARB2","scavenger receptor class B member 2",TRUE
+"201647_s_at",0.868397087637799,0.503216373438384,-0.680534190925771,-5.71659445166867,-0.321331204932312,"SCARB2","scavenger receptor class B member 2",TRUE
+"206995_x_at",0.800887499728059,0.336791922703635,0.981813168152065,-5.48077493803848,0.576316564098853,"SCARF1","scavenger receptor class F member 1",TRUE
+"1555021_a_at",0.816826348926082,0.369024739731562,-0.916984389097815,-5.53822565665037,-0.243484108018915,"SCARF1","scavenger receptor class F member 1",TRUE
+"241691_at",0.823074246722209,0.389610592522727,-0.877538638689958,-5.57141172990202,-0.450255104936595,"SCARF2","scavenger receptor class F member 2",TRUE
+"239454_at",0.830635993561085,0.403862303053585,0.851019594227115,-5.59296087525669,0.89691231186645,"SCARF2","scavenger receptor class F member 2",TRUE
+"227557_at",0.972411709729607,0.867051545697816,0.169358275173431,-5.92572307441601,0.191783818076429,"SCARF2","scavenger receptor class F member 2",TRUE
+"244786_at",0.892746695408886,0.565640230489267,0.583211985271668,-5.77535987087505,0.317177039672007,"SCARNA13///SNHG10","small Cajal body-specific RNA 13///small nucleolar RNA host gene 10",TRUE
+"238691_at",0.998870448604467,0.996315112591863,0.00467072591890902,-5.939672855141,0.00315091815649371,"SCARNA13///SNHG10","small Cajal body-specific RNA 13///small nucleolar RNA host gene 10",TRUE
+"228930_at",0.78226567430527,0.304450503585585,-1.05130408581675,-5.41523866882364,-0.407316877575143,"SCARNA15","small Cajal body-specific RNA 15",TRUE
+"240830_at",0.743482925985952,0.233889461855663,-1.22378207646395,-5.23543040474258,-0.753153934549044,"SCARNA17","small Cajal body-specific RNA 17",TRUE
+"237137_at",0.983935461205724,0.921306981459248,0.0999192946693179,-5.9348218776524,0.0755463259386282,"SCARNA2","small Cajal body-specific RNA 2",TRUE
+"1569212_at",0.730389679155928,0.213098786683043,1.28198960439772,-5.16940997172563,0.621830037648007,"SCART1","scavenger receptor protein family member",TRUE
+"201825_s_at",0.90466378569832,0.608743055756562,0.519237928780051,-5.80921368098028,0.60670529860481,"SCCPDH","saccharopine dehydrogenase (putative)",TRUE
+"201826_s_at",0.984132887597385,0.922106064653398,0.0989011890981881,-5.93492042214768,0.0772521883274493,"SCCPDH","saccharopine dehydrogenase (putative)",TRUE
+"200832_s_at",0.520083117553428,0.0376780837426452,-2.21071382260686,-3.80407071057373,-1.19064530802041,"SCD","stearoyl-CoA desaturase",TRUE
+"200831_s_at",0.627092759817312,0.0982430261155826,-1.72613593004637,-4.58413572232475,-1.15569569437979,"SCD","stearoyl-CoA desaturase",TRUE
+"211162_x_at",0.778397054392363,0.298160239717476,-1.0654171021332,-5.40143609301766,-1.00190000204865,"SCD","stearoyl-CoA desaturase",TRUE
+"211708_s_at",0.780655891246127,0.302253398478084,-1.05620979180877,-5.41045959457122,-0.998745181774922,"SCD","stearoyl-CoA desaturase",TRUE
+"224901_at",0.729273475042162,0.211477698379153,1.28670857019109,-5.16394273184775,1.78629852070646,"SCD5","stearoyl-CoA desaturase 5",TRUE
+"224018_s_at",0.819018525257656,0.374178592128703,0.906975444105002,-5.54677393130962,1.05182850449237,"SCD5","stearoyl-CoA desaturase 5",TRUE
+"224019_at",0.860714927752408,0.480396208419814,0.717774985158719,-5.69181607110155,0.484865385031524,"SCD5","stearoyl-CoA desaturase 5",TRUE
+"220232_at",0.921727601757524,0.666023796905908,0.437443866310061,-5.84690782271675,0.160371717993976,"SCD5","stearoyl-CoA desaturase 5",TRUE
+"206884_s_at",0.050114022740896,6.78269352140156e-05,4.88815516798415,1.71242098030126,5.46886756957835,"SCEL","sciellin",TRUE
+"232056_at",0.131554208455398,0.000813403010743391,3.87291909282864,-0.474424833200063,3.86840973668298,"SCEL","sciellin",TRUE
+"1554921_a_at",0.296090407530139,0.00529767384089388,3.09172629728593,-2.12142449552779,3.23041977671689,"SCEL","sciellin",TRUE
+"1554920_at",0.774230543658252,0.289090118943929,1.08614657308333,-5.38086413999154,1.06430560904006,"SCEL","sciellin",TRUE
+"215548_s_at",0.861981304384929,0.484688621575745,-0.71069355868039,-5.69662459712695,-0.211395042155793,"SCFD1","sec1 family domain containing 1",TRUE
+"233229_at",0.991359510893995,0.959447435188948,0.0514253022145086,-5.93839549433027,0.0391250087097879,"SCFD1","sec1 family domain containing 1",TRUE
+"236834_at",0.819018525257656,0.375133054901364,-0.90513188141543,-5.54833900607305,-0.346931923168322,"SCFD2","sec1 family domain containing 2",TRUE
+"226923_at",0.91339551560427,0.63692878603577,-0.478576342749846,-5.82874033680953,-0.180899765719685,"SCFD2","sec1 family domain containing 2",TRUE
+"204035_at",0.789795896476304,0.318216091832577,1.02112451926757,-5.44419834998555,0.857063156906537,"SCG2","secretogranin II",TRUE
+"219196_at",0.937735933140623,0.724444958023352,-0.357033214864553,-5.87778622318818,-0.377895300827574,"SCG3","secretogranin III",TRUE
+"203889_at",0.371465994318089,0.0111898398288412,2.76743165681057,-2.77101494774906,2.13408001940178,"SCG5","secretogranin V",TRUE
+"205725_at",0.866807918403275,0.498190946138503,0.688651006960512,-5.71130124741379,0.478386094486697,"SCGB1A1","secretoglobin family 1A member 1",TRUE
+"1552449_a_at",0.800179799309599,0.335712123971445,-0.984056653719477,-5.47872263182275,-0.671010549427064,"SCGB1C2///SCGB1C1","secretoglobin family 1C member 2///secretoglobin family 1C member 1",TRUE
+"207910_at",0.937232018318296,0.721534262919212,-0.360978886718833,-5.8764148762256,-0.377368969138224,"SCGB1D1","secretoglobin family 1D member 1",TRUE
+"206799_at",0.787929163003677,0.313902874575521,-1.030480139421,-5.43530221466883,-2.22097647033786,"SCGB1D2","secretoglobin family 1D member 2",TRUE
+"205979_at",0.750807729565285,0.24388377278609,-1.19719245037886,-5.26470740233846,-2.3285495820241,"SCGB2A1","secretoglobin family 2A member 1",TRUE
+"206378_at",0.72713608277202,0.207348489556444,-1.29885626529218,-5.14979027355608,-2.56216790649321,"SCGB2A2","secretoglobin family 2A member 2",TRUE
+"237748_at",0.983498417373669,0.919405998390033,0.102341759132156,-5.93458334882889,0.067952596192348,"SCGB2B2","secretoglobin family 2B member 2",TRUE
+"230378_at",0.933859583363678,0.70705633815052,0.380693318233797,-5.86934015648599,0.159194689505779,"SCGB3A1","secretoglobin family 3A member 1",TRUE
+"228782_at",0.171054203824867,0.00147355336079583,3.62833837259975,-0.998287210589133,2.53439044900363,"SCGB3A2","secretoglobin family 3A member 2",TRUE
+"205697_at",0.993819570187391,0.970745096456912,0.0370903763000154,-5.93901345215547,0.0388963858891342,"SCGN","secretagogin, EF-hand calcium binding protein",TRUE
+"233855_at",0.796327569283512,0.32858395049515,0.998993035738618,-5.46495050072371,0.609205536588847,"SCIMP","SLP adaptor and CSK interacting membrane protein",TRUE
+"239365_at",0.255716413540338,0.00367812481526215,3.24661829181226,-1.80226288254688,1.47874466884465,"SCIN","scinderin",TRUE
+"1552367_a_at",0.94895689004559,0.768752282990022,-0.297638073349983,-5.8966271992158,-0.58545013208768,"SCIN","scinderin",TRUE
+"222272_x_at",0.95238233774064,0.782072348579583,-0.28000345652154,-5.90156876997677,-0.343691787182438,"SCIN","scinderin",TRUE
+"1552365_at",0.970893641742918,0.860882417365731,-0.177301504381322,-5.92438383878727,-0.32000806888989,"SCIN","scinderin",TRUE
+"221575_at",0.68033297785336,0.147619309900199,-1.50043001717116,-4.89889296936777,-0.444102957922095,"SCLY","selenocysteine lyase",TRUE
+"59705_at",0.910888708415045,0.628211815750021,0.49106136048836,-5.82291008518246,0.218355593242273,"SCLY","selenocysteine lyase",TRUE
+"219808_at",0.922168942129244,0.667981993693104,0.434703634772183,-5.84806127024588,0.280206545603062,"SCLY","selenocysteine lyase",TRUE
+"221216_s_at",0.836752569023453,0.418551293026412,-0.824306243474141,-5.6140440370483,-0.265872811076486,"SCMH1","sex comb on midleg homolog 1 (Drosophila)",TRUE
+"222747_s_at",0.673870607802125,0.140480607000066,-1.52874044826984,-4.86130727873451,-0.819595621058999,"SCML1","sex comb on midleg-like 1 (Drosophila)",TRUE
+"218793_s_at",0.855805293258105,0.469144077444486,-0.736515562578458,-5.67887196565355,-0.524087163739907,"SCML1","sex comb on midleg-like 1 (Drosophila)",TRUE
+"206147_x_at",0.603702127972549,0.0778290613527746,-1.84911165604101,-4.39882265709203,-0.720028092643458,"SCML2","sex comb on midleg-like 2 (Drosophila)",TRUE
+"1569225_a_at",0.575685768373148,0.0609747834412236,1.97402926705665,-4.20138191426479,1.38080403241847,"SCML4","sex comb on midleg-like 4 (Drosophila)",TRUE
+"1556472_s_at",0.769258076576208,0.276520092460201,-1.11566475715286,-5.35096141713116,-0.790804613956608,"SCML4","sex comb on midleg-like 4 (Drosophila)",TRUE
+"1563542_a_at",0.831875452294783,0.407722096061576,0.843941184813834,-5.59860856022632,0.584766658603194,"SCML4","sex comb on midleg-like 4 (Drosophila)",TRUE
+"1555356_a_at",0.933922051839063,0.70720783551918,-0.380486242281503,-5.86941639584985,-0.261818601307306,"SCML4","sex comb on midleg-like 4 (Drosophila)",TRUE
+"1556471_at",0.995375928428862,0.978375184289584,0.0274137074145204,-5.93931745390537,0.0225527996070376,"SCML4","sex comb on midleg-like 4 (Drosophila)",TRUE
+"208578_at",0.940227139261806,0.732887506094671,0.345621031294166,-5.88166878182332,0.109875146434027,"SCN10A","sodium voltage-gated channel alpha subunit 10",TRUE
+"220791_x_at",0.9116561917482,0.630606100715262,-0.487624301122805,-5.82452976176649,-0.337345468317684,"SCN11A","sodium voltage-gated channel alpha subunit 11",TRUE
+"224029_x_at",0.947326616179611,0.760457224168875,0.308668538565325,-5.89338417080175,0.324950802217542,"SCN11A","sodium voltage-gated channel alpha subunit 11",TRUE
+"210853_at",0.978197434639598,0.894218870001134,-0.134503392106098,-5.93087578214785,-0.081210534587246,"SCN11A","sodium voltage-gated channel alpha subunit 11",TRUE
+"1555246_a_at",0.925375904025762,0.676637578866685,-0.422631388179158,-5.8530580660549,-0.32293031311204,"SCN1A","sodium voltage-gated channel alpha subunit 1",TRUE
+"210383_at",0.98539961718117,0.927761747594556,0.0916983243040614,-5.93558879986157,0.135038076349107,"SCN1A","sodium voltage-gated channel alpha subunit 1",TRUE
+"205508_at",0.726696341943087,0.206915848265817,1.30013986439597,-5.14828824562746,0.664227150651056,"SCN1B","sodium voltage-gated channel beta subunit 1",TRUE
+"229057_at",0.287796329902695,0.00490385004607288,3.12467585885489,-2.05395128211951,2.44095296958421,"SCN2A","sodium voltage-gated channel alpha subunit 2",TRUE
+"206381_at",0.526253358601247,0.0396554994582369,2.18609851811546,-3.84671346298434,1.55874074220205,"SCN2A","sodium voltage-gated channel alpha subunit 2",TRUE
+"210364_at",0.627053909308516,0.0978382941226962,1.7283507090538,-4.5808812303484,1.16786145391565,"SCN2B","sodium voltage-gated channel beta subunit 2",TRUE
+"210363_s_at",0.929720878114947,0.689991478212532,-0.40412998578595,-5.8604473812488,-0.147579121542029,"SCN2B","sodium voltage-gated channel beta subunit 2",TRUE
+"235225_at",0.986342822130003,0.933172344100219,0.0848122464149027,-5.93618058579885,0.034421376026855,"SCN2B","sodium voltage-gated channel beta subunit 2",TRUE
+"232512_at",0.725143559947316,0.203273057933022,1.31103109566443,-5.13549310672519,0.902779671838122,"SCN3A","sodium voltage-gated channel alpha subunit 3",TRUE
+"210432_s_at",0.734861913384601,0.219814005590192,1.26273132325798,-5.19154420571427,1.1067944540622,"SCN3A","sodium voltage-gated channel alpha subunit 3",TRUE
+"204722_at",0.896115372949367,0.577584024114248,-0.565248646659984,-5.78525069101954,-0.195090870013153,"SCN3B","sodium voltage-gated channel beta subunit 3",TRUE
+"204723_at",0.908451397680106,0.619387123549827,-0.503781805676069,-5.81681907891944,-0.270526716469783,"SCN3B","sodium voltage-gated channel beta subunit 3",TRUE
+"206981_at",0.819018525257656,0.374173764332506,0.906984776979057,-5.54676600077499,0.31920251752473,"SCN4A","sodium voltage-gated channel alpha subunit 4",TRUE
+"236359_at",0.830398314753695,0.402808171339523,-0.852960260060342,-5.59140478453717,-0.735352248718024,"SCN4B","sodium voltage-gated channel beta subunit 4",TRUE
+"207413_s_at",0.597654932724127,0.0747667097517403,1.86991867481182,-4.36656280687843,1.18547623873498,"SCN5A","sodium voltage-gated channel alpha subunit 5",TRUE
+"207864_at",0.640890774222346,0.111397564754574,1.6580592659882,-4.68263754468097,0.968345733366331,"SCN7A","sodium voltage-gated channel alpha subunit 7",TRUE
+"228504_at",0.791838559691106,0.322568892817819,1.01177262422323,-5.4530176295986,0.964258586400519,"SCN7A","sodium voltage-gated channel alpha subunit 7",TRUE
+"244708_at",0.631299908494113,0.102412948266292,-1.70375892723722,-4.61684249526203,-0.9227317924254,"SCN8A","sodium voltage-gated channel alpha subunit 8",TRUE
+"235969_at",0.783951674059447,0.306970670140625,-1.04570788036179,-5.42066600957907,-0.690720794252096,"SCN8A","sodium voltage-gated channel alpha subunit 8",TRUE
+"236329_at",0.846898808963473,0.445556618209288,-0.77668685935518,-5.65006148170208,-0.301700101922905,"SCN8A","sodium voltage-gated channel alpha subunit 8",TRUE
+"1561820_at",0.85334340854827,0.461425605882958,0.749524702168417,-5.6697004660469,0.27466744236064,"SCN8A","sodium voltage-gated channel alpha subunit 8",TRUE
+"237790_at",0.859781203630624,0.477993664702905,-0.721754675857241,-5.68909382003618,-0.622741259931108,"SCN8A","sodium voltage-gated channel alpha subunit 8",TRUE
+"207049_at",0.940044918888428,0.730651492140607,0.348638939990164,-5.88065417566023,0.241893180758771,"SCN8A","sodium voltage-gated channel alpha subunit 8",TRUE
+"229199_at",0.869056640409671,0.505539029688698,0.676798238866568,-5.71901060440466,0.84601149999283,"SCN9A","sodium voltage-gated channel alpha subunit 9",TRUE
+"206950_at",0.964181293782946,0.835558774961858,0.210036261946499,-5.91821939163268,0.213102564439957,"SCN9A","sodium voltage-gated channel alpha subunit 9",TRUE
+"215026_x_at",0.6708432030569,0.136522533694848,1.5449500770639,-4.83953553677346,1.2394232444414,"SCNN1A","sodium channel epithelial 1 alpha subunit",TRUE
+"217264_s_at",0.723649742218726,0.200262305598467,1.32014787035443,-5.12471325599398,0.819139903182754,"SCNN1A","sodium channel epithelial 1 alpha subunit",TRUE
+"203453_at",0.859502367311367,0.477344167422482,0.722832539608657,-5.6883540593321,1.1411255373152,"SCNN1A","sodium channel epithelial 1 alpha subunit",TRUE
+"205464_at",0.622666296576048,0.0931807158406077,-1.75441834220539,-4.5423438934254,-1.69223470297216,"SCNN1B","sodium channel epithelial 1 beta subunit",TRUE
+"208458_at",0.878788356961452,0.53218772975167,0.634600286245703,-5.74541545442451,0.619607165553774,"SCNN1D","sodium channel epithelial 1 delta subunit",TRUE
+"207295_at",0.617775129514679,0.0885352433557517,1.78155590638169,-4.50177385861503,0.601302750415384,"SCNN1G","sodium channel epithelial 1 gamma subunit",TRUE
+"241436_at",0.841247691968787,0.43138695857574,0.801442570644003,-5.63158853160659,1.23499504126752,"SCNN1G","sodium channel epithelial 1 gamma subunit",TRUE
+"223221_at",0.988831277987108,0.946290104657415,-0.0681339963681033,-5.93742266901349,-0.0241630137994715,"SCO1","SCO1 cytochrome c oxidase assembly protein",TRUE
+"205241_at",0.925511384407886,0.677894546671424,-0.420883591768568,-5.85377003227329,-0.172790335984001,"SCO2","SCO2 cytochrome c oxidase assembly protein",TRUE
+"224786_at",0.68529926526524,0.153910644915714,-1.476392736954,-4.93036275961592,-0.395966181816775,"SCOC","short coiled-coil protein",TRUE
+"223341_s_at",0.739367922105944,0.22730354033604,-1.24177742973001,-5.21530107700745,-0.38494046570441,"SCOC","short coiled-coil protein",TRUE
+"1556736_at",0.682825347106105,0.150897575490197,1.48780286953324,-4.91547552258782,0.951822027189408,"SCOC-AS1","SCOC antisense RNA 1",TRUE
+"235869_at",0.739967059169175,0.228384894805301,1.23879578005977,-5.2186538062147,0.558676727434618,"SCOC-AS1","SCOC antisense RNA 1",TRUE
+"201339_s_at",0.760227035076299,0.258088242580649,-1.16077330184843,-5.30389733823948,-0.355873934105038,"SCP2","sterol carrier protein 2",TRUE
+"211733_x_at",0.806735395676905,0.347977128266132,-0.958858570870327,-5.50152782566576,-0.261783339326616,"SCP2","sterol carrier protein 2",TRUE
+"231134_at",0.895657764833717,0.575144881930367,-0.568901664444756,-5.78326358190893,-0.281453717009175,"SCP2D1","SCP2 sterol binding domain containing 1",TRUE
+"1560665_at",0.485571841560871,0.0281618346518431,-2.34871679959729,-3.55975867309313,-1.28764955159174,"SCPEP1","serine carboxypeptidase 1",TRUE
+"218217_at",0.924874199396311,0.675019498294945,0.424883280071032,-5.85213648112019,0.29845320859159,"SCPEP1","serine carboxypeptidase 1",TRUE
+"243984_at",0.680708651141727,0.148508603731281,-1.49698222608905,-4.90343193656081,-1.49345100724856,"SCRG1","stimulator of chondrogenesis 1",TRUE
+"205475_at",0.990810941805126,0.955209060157922,-0.0568058068450241,-5.93811189909793,-0.0599571588988281,"SCRG1","stimulator of chondrogenesis 1",TRUE
+"212556_at",0.715677574404058,0.191475657217788,1.34738149555124,-5.09213749509208,0.576507348678406,"SCRIB","scribbled planar cell polarity protein",TRUE
+"201462_at",0.921980251030053,0.667133932982962,0.435889964569542,-5.8475627811759,0.275220297215547,"SCRN1","secernin 1",TRUE
+"225513_at",0.925549026820891,0.678346604531628,-0.420255337612894,-5.85402524342813,-0.186261035738211,"SCRN2","secernin 2",TRUE
+"228730_s_at",0.96745816444974,0.847558822477881,-0.194497296110123,-5.92127505152992,-0.0801921294341419,"SCRN2","secernin 2",TRUE
+"1555595_at",0.314126572995991,0.00668313867932853,-2.99206496388515,-2.32398423033374,-1.20704323761642,"SCRN3","secernin 3",TRUE
+"219234_x_at",0.525405708458677,0.0393710613801863,-2.18956972441928,-3.84071780949297,-0.953796961092402,"SCRN3","secernin 3",TRUE
+"222849_s_at",0.622434989367596,0.0929950256046643,-1.75548055684135,-4.54076451777775,-0.746568517666406,"SCRN3","secernin 3",TRUE
+"232108_at",0.983364220761052,0.918860741633888,-0.103036706936487,-5.93451386693308,-0.060537257575004,"SCRN3","secernin 3",TRUE
+"221026_s_at",0.634202341398092,0.105381404144521,-1.68829687884765,-4.63925494492605,-0.802465370788053,"SCRT1","scratch family transcriptional repressor 1",TRUE
+"228761_at",0.998384473324293,0.993406558554542,0.00835749158723151,-5.93964946058369,0.00546324666277975,"SCRT1","scratch family transcriptional repressor 1",TRUE
+"221198_at",0.863003954607479,0.487023082202355,0.70685752868533,-5.69921043095553,0.214019021175832,"SCT","secretin",TRUE
+"1565738_at",0.763650705722297,0.263603836969486,-1.14703297432338,-5.31840732213526,-1.02037853275545,"SCTR","secretin receptor",TRUE
+"1565737_at",0.78969417320323,0.317573760520814,1.02251211451611,-5.44288353236916,0.527488575895971,"SCTR","secretin receptor",TRUE
+"210382_at",0.958792863216689,0.813476279450551,-0.238772961677012,-5.91195286870851,-0.175804799575358,"SCTR","secretin receptor",TRUE
+"233988_x_at",0.900774308374385,0.596476046660116,0.537211284651481,-5.80008821449882,0.389628786372948,"SCUBE1","signal peptide, CUB domain and EGF like domain containing 1",TRUE
+"219197_s_at",0.635368778245437,0.106241876765704,-1.68388397229647,-4.64562324632452,-2.85875211030534,"SCUBE2","signal peptide, CUB domain and EGF like domain containing 2",TRUE
+"230253_at",0.775351898377291,0.292185343926214,1.07902075965577,-5.38797574966447,0.580943000612304,"SCUBE3","signal peptide, CUB domain and EGF like domain containing 3",TRUE
+"230290_at",0.955816406528307,0.798704063518437,0.25811041137218,-5.90728684831197,0.246935294073303,"SCUBE3","signal peptide, CUB domain and EGF like domain containing 3",TRUE
+"228407_at",0.965562220217804,0.838833834442167,0.20579027214163,-5.91907755952761,0.143576956333289,"SCUBE3","signal peptide, CUB domain and EGF like domain containing 3",TRUE
+"217600_at",0.979794616772313,0.903686465834007,0.122398968490223,-5.93238917416346,0.082529784518159,"SCUBE3","signal peptide, CUB domain and EGF like domain containing 3",TRUE
+"223033_s_at",0.552420073963858,0.0498952286225271,-2.0740574381027,-4.03701306033451,-0.70145205374939,"SCYL1","SCY1 like pseudokinase 1",TRUE
+"229601_at",0.859007507248125,0.475451032178194,-0.725979170069643,-5.68618845708501,-0.511655913477852,"SCYL1","SCY1 like pseudokinase 1",TRUE
+"224961_at",0.686162889425718,0.154909267998166,-1.47265112556352,-4.93522443779763,-0.595475843114736,"SCYL2","SCY1 like pseudokinase 2",TRUE
+"224960_at",0.723973974120865,0.200981826858781,-1.3179594445499,-5.12730664565685,-0.43406098246825,"SCYL2","SCY1 like pseudokinase 2",TRUE
+"221220_s_at",0.802375933455311,0.340160434596445,-0.974846037696226,-5.48712115213729,-0.406000503035331,"SCYL2","SCY1 like pseudokinase 2",TRUE
+"41329_at",0.51470556386048,0.0349877343913534,-2.24616142142914,-3.74215385430108,-1.25276854592578,"SCYL3","SCY1 like pseudokinase 3",TRUE
+"231111_at",0.627092759817312,0.0985169353051659,-1.72464145516428,-4.58633001192358,-0.980659615594771,"SCYL3","SCY1 like pseudokinase 3",TRUE
+"205607_s_at",0.694819513561858,0.164398668806582,-1.43803759951544,-4.97972456900817,-0.823024411548388,"SCYL3","SCY1 like pseudokinase 3",TRUE
+"224037_at",0.486821797225537,0.0287019443087829,-2.33981305931433,-3.57578047770289,-1.11419488739862,"SDAD1","SDA1 domain containing 1",TRUE
+"218607_s_at",0.643688366500038,0.11438248726333,-1.64356550318106,-4.70322020023113,-0.564977478516301,"SDAD1","SDA1 domain containing 1",TRUE
+"228408_s_at",0.925511384407886,0.677803730826937,-0.421009825215154,-5.85371870815356,-0.158844007694093,"SDAD1","SDA1 domain containing 1",TRUE
+"201286_at",0.835513930382091,0.414814943717048,-0.831044085934228,-5.60878555557075,-0.571827980434438,"SDC1","syndecan 1",TRUE
+"201287_s_at",0.841550580403629,0.433166935247255,-0.798305554315757,-5.63395957456885,-0.455599040891441,"SDC1","syndecan 1",TRUE
+"212154_at",0.535697382361465,0.0429671494960796,-2.14726228301934,-3.91339059264563,-2.79695173915958,"SDC2","syndecan 2",TRUE
+"212157_at",0.617775129514679,0.0888345988633236,-1.77977068279411,-4.50445673906827,-1.60638580036695,"SDC2","syndecan 2",TRUE
+"212158_at",0.634684756518518,0.105620834542616,-1.68706591007014,-4.64103263180304,-3.03809848491044,"SDC2","syndecan 2",TRUE
+"1554864_a_at",0.635916735157933,0.106971877134251,1.6801638666456,-4.65098197245278,0.819319072863299,"SDC3","syndecan 3",TRUE
+"202898_at",0.959835805524877,0.818375230839565,0.232380893230451,-5.91341581670458,0.0733220993449422,"SDC3","syndecan 3",TRUE
+"202071_at",0.978928101156583,0.897466822048649,-0.13034862421438,-5.93141129298566,-0.0740565075753352,"SDC4","syndecan 4",TRUE
+"200958_s_at",0.784918343662568,0.309574381271792,1.03996021110442,-5.42621311989464,0.396293037592306,"SDCBP","syndecan binding protein",TRUE
+"239248_at",0.83030603167465,0.402602672569781,-0.853338963814514,-5.5911007419899,-0.421702372749608,"SDCBP2-AS1","SDCBP2 antisense RNA 1",TRUE
+"236669_at",0.89203601623083,0.562288793284562,0.588287259460894,-5.77251110740748,0.341885019564389,"SDCBP2-AS1","SDCBP2 antisense RNA 1",TRUE
+"236520_at",0.892241540026968,0.564458027032333,0.585000492552496,-5.77435870231377,0.325459378228913,"SDCBP2-AS1","SDCBP2 antisense RNA 1",TRUE
+"233530_at",0.93523910610914,0.7118565481073,-0.374140273059303,-5.87173295802258,-0.383208845344049,"SDCBP2-AS1","SDCBP2 antisense RNA 1",TRUE
+"1569952_x_at",0.646692716816097,0.117599250884226,1.62829782926031,-4.72475196271873,0.781211384588589,"SDCBPP2","syndecan binding protein pseudogene 2",TRUE
+"238111_at",0.67368843181164,0.140241221847844,-1.52971006257259,-4.86001008021103,-0.799233649708867,"SDCCAG3","serologically defined colon cancer antigen 3",TRUE
+"218427_at",0.904832003218088,0.609673568860385,-0.517881675260812,-5.80989000992345,-0.170188661370064,"SDCCAG3","serologically defined colon cancer antigen 3",TRUE
+"230058_at",0.967098323798013,0.846443203143236,-0.19593979733789,-5.92100123768462,-0.0633858347900222,"SDCCAG3","serologically defined colon cancer antigen 3",TRUE
+"1554237_at",0.878278790222455,0.530973105790919,0.636498058867395,-5.74426299659757,0.328290542930371,"SDCCAG8","serologically defined colon cancer antigen 8",TRUE
+"1553034_at",0.936992192746977,0.719077063453329,0.364314359100864,-5.87524400014612,0.194554691607475,"SDCCAG8","serologically defined colon cancer antigen 8",TRUE
+"227785_at",0.942502815705589,0.742020013764878,0.333328610572914,-5.88571130943062,0.15136583982359,"SDCCAG8","serologically defined colon cancer antigen 8",TRUE
+"243772_at",0.984244246588495,0.923311545707778,0.09736549749302,-5.93506715734532,0.0589744025524768,"SDCCAG8","serologically defined colon cancer antigen 8",TRUE
+"244103_at",0.92887101967341,0.686787044410331,0.408556313803989,-5.85870915037595,0.145659771853833,"SDE2","SDE2 telomere maintenance homolog",TRUE
+"1553338_at",0.967388727966307,0.847321057038472,0.194804692469604,-5.92121687094027,0.0804728245454545,"SDE2","SDE2 telomere maintenance homolog",TRUE
+"203090_at",0.971943273048675,0.865678472833352,0.17112522944403,-5.92543045689648,0.0558875421571958,"SDF2","stromal cell derived factor 2",TRUE
+"218681_s_at",0.956734254923335,0.803667672087622,-0.251601987223602,-5.90889759906686,-0.14606402596892,"SDF2L1","stromal cell derived factor 2 like 1",TRUE
+"217855_x_at",0.86731034667719,0.499598774120873,-0.686372492096322,-5.71279318563986,-0.239468487413358,"SDF4","stromal cell derived factor 4",TRUE
+"232032_x_at",0.947926063538122,0.762936446241945,0.305367725954961,-5.89436689333877,0.129341553067748,"SDF4","stromal cell derived factor 4",TRUE
+"224472_x_at",0.98529096111871,0.926937798021945,-0.0927473569306564,-5.93549459686113,-0.0291238873471134,"SDF4","stromal cell derived factor 4",TRUE
+"221972_s_at",0.997263441064271,0.986035876620083,-0.017700922062606,-5.9395308739946,-0.00615994202062708,"SDF4","stromal cell derived factor 4",TRUE
+"201093_x_at",0.69880142086258,0.170086299921538,1.41805625766197,-5.00501957516736,0.642414819938036,"SDHA","succinate dehydrogenase complex flavoprotein subunit A",TRUE
+"44669_at",0.516444287133032,0.0363412505034956,-2.22802900995096,-3.77390031777048,-0.815086143035304,"SDHAF1","succinate dehydrogenase complex assembly factor 1",TRUE
+"221855_at",0.552420073963858,0.0498977426212166,-2.07403257662288,-4.03705457599104,-0.633921676227775,"SDHAF1","succinate dehydrogenase complex assembly factor 1",TRUE
+"223048_at",0.838294736493351,0.42306477666321,-0.816217236599404,-5.62030405690783,-0.267429594848439,"SDHAF2","succinate dehydrogenase complex assembly factor 2",TRUE
+"218981_at",0.764773853888404,0.2648479192789,1.14396313221151,-5.32162835260689,2.68079829420857,"SDHAF3","succinate dehydrogenase complex assembly factor 3",TRUE
+"238504_at",0.983928934193381,0.921195029033836,0.100061940984389,-5.93480799009656,0.0612355792895452,"SDHAF4","succinate dehydrogenase complex assembly factor 4",TRUE
+"226693_at",0.903919439852106,0.605869880425425,0.523431922319951,-5.80711134065042,0.210296195418133,"SDHAP2///LINC00969///SDHAP1","succinate dehydrogenase complex flavoprotein subunit A pseudogene 2///long intergenic non-protein coding RNA 969///succinate dehydrogenase complex flavoprotein subunit A pseudogene 1",TRUE
+"222021_x_at",0.787614476800604,0.313389171336025,1.03160039578576,-5.43423206944084,0.388714533734218,"SDHAP2///SDHAP1","succinate dehydrogenase complex flavoprotein subunit A pseudogene 2///succinate dehydrogenase complex flavoprotein subunit A pseudogene 1",TRUE
+"230077_at",0.803111243433434,0.340901106159762,0.97332044848066,-5.48850528026909,0.415458621295806,"SDHAP2///SDHAP1///LOC220729///SDHA","succinate dehydrogenase complex flavoprotein subunit A pseudogene 2///succinate dehydrogenase complex flavoprotein subunit A pseudogene 1///succinate dehydrogenase complex flavoprotein subunit A pseudogene///succinate dehydrogenase complex flavoprotein subunit A",TRUE
+"234297_at",0.960819760730297,0.821913282436345,-0.227770667738836,-5.91444644340741,-0.12478754032249,"SDHAP3///RGS8","succinate dehydrogenase complex flavoprotein subunit A pseudogene 3///regulator of G-protein signaling 8",TRUE
+"214166_at",0.921079309141156,0.664036271210186,-0.440228624582922,-5.84572834308752,-0.313241583808029,"SDHB","succinate dehydrogenase complex iron sulfur subunit B",TRUE
+"202675_at",0.978404064916532,0.896159070268953,-0.132021208524695,-5.93119772947554,-0.04563921781142,"SDHB","succinate dehydrogenase complex iron sulfur subunit B",TRUE
+"216591_s_at",0.509163975230892,0.0337824652612869,-2.26285453488627,-3.7127913367481,-0.743551675962147,"SDHC","succinate dehydrogenase complex subunit C",TRUE
+"215088_s_at",0.517654151778308,0.0367520849652476,-2.22264689072784,-3.78329352945563,-0.699506559382721,"SDHC","succinate dehydrogenase complex subunit C",TRUE
+"202004_x_at",0.528328646587879,0.0409503172403948,-2.17057662066638,-3.87345178899029,-0.696974584957163,"SDHC","succinate dehydrogenase complex subunit C",TRUE
+"232107_at",0.565735799092003,0.0566304897746782,-2.01115448768926,-4.14100704833565,-1.22853839093671,"SDHC","succinate dehydrogenase complex subunit C",TRUE
+"210131_x_at",0.593339168375633,0.0704469687053818,-1.9005715451708,-4.31857484143852,-0.635239876653266,"SDHC","succinate dehydrogenase complex subunit C",TRUE
+"238056_at",0.601326892459196,0.0768554608962938,-1.85564820986859,-4.38871577215909,-0.800295059198685,"SDHC","succinate dehydrogenase complex subunit C",TRUE
+"238191_at",0.702532890944443,0.173904554448084,-1.40494067276607,-5.02146492566825,-0.62094633282774,"SDHC","succinate dehydrogenase complex subunit C",TRUE
+"215652_at",0.767727587789514,0.269941797277909,1.1315032360115,-5.33462377299574,0.574628345184943,"SDHD","succinate dehydrogenase complex subunit D",TRUE
+"202026_at",0.854092692629534,0.463467326888443,0.74607096357379,-5.67215020594909,0.245623048019468,"SDHD","succinate dehydrogenase complex subunit D",TRUE
+"229912_at",0.820536502908875,0.379956194757574,-0.895862904113754,-5.55616321128434,-0.66495652487172,"SDK1","sidekick cell adhesion molecule 1",TRUE
+"229407_at",0.991689960875868,0.961356950489758,-0.0490017412053821,-5.93851402673153,-0.0482566585310904,"SDK1","sidekick cell adhesion molecule 1",TRUE
+"242064_at",0.682825347106105,0.15085313656948,-1.4879725364692,-4.91525345499948,-1.81587003464539,"SDK2","sidekick cell adhesion molecule 2",TRUE
+"233585_at",0.710824498521146,0.184197130457639,1.37069487271664,-5.06380893989892,0.877670546871233,"SDK2","sidekick cell adhesion molecule 2",TRUE
+"220628_s_at",0.911028479628096,0.628781246943744,0.490243384741848,-5.82329655522435,0.329856217501546,"SDK2","sidekick cell adhesion molecule 2",TRUE
+"234073_at",0.921727601757524,0.665980607340987,0.437504342565817,-5.84688228614925,0.150606099269289,"SDK2","sidekick cell adhesion molecule 2",TRUE
+"232061_at",0.942502815705589,0.742502594345441,-0.33268052510294,-5.88592042285331,-0.282154881780474,"SDK2","sidekick cell adhesion molecule 2",TRUE
+"218711_s_at",0.813442508625161,0.363609725529345,-0.927601148095018,-5.52906380518295,-0.712035920897367,"SDPR","serum deprivation response",TRUE
+"222717_at",0.823518986434235,0.390467890516018,0.87592584758996,-5.57273981815688,1.51767783097724,"SDPR","serum deprivation response",TRUE
+"238017_at",0.835083899263907,0.413906633619138,-0.83268784491298,-5.60749662412088,-0.954002021346423,"SDR16C5","short chain dehydrogenase/reductase family 16C, member 5",TRUE
+"213398_s_at",0.48580305784244,0.0284870972182762,-2.34333620954835,-3.56944490066424,-0.8654264058707,"SDR39U1","short chain dehydrogenase/reductase family 39U member 1",TRUE
+"241356_at",0.84932977991296,0.450322252760119,0.768469220391416,-5.65607274396633,0.606840769146172,"SDR42E1","short chain dehydrogenase/reductase family 42E, member 1",TRUE
+"229522_at",0.854400503339099,0.465396164285973,0.742816491023647,-5.67444879407684,0.67790182520238,"SDR42E1","short chain dehydrogenase/reductase family 42E, member 1",TRUE
+"1553077_at",0.955892698633978,0.799886430767057,-0.256559034652347,-5.90767450444801,-0.136435814827959,"SDR9C7","short chain dehydrogenase/reductase family 9C, member 7",TRUE
+"205695_at",0.975265330414469,0.880376419495187,0.15223875593275,-5.92840129523166,0.0476188946859599,"SDS","serine dehydratase",TRUE
+"1555539_at",0.989638901366417,0.949933187193084,0.0635058080236746,-5.93771935205266,0.0416879828252901,"SDS","serine dehydratase",TRUE
+"228274_at",0.457032025390949,0.0225898435562267,-2.45109850045697,-3.37310110953389,-1.40758317954858,"SDSL","serine dehydratase like",TRUE
+"234256_at",0.766550448794594,0.267715250225054,-1.13692804893769,-5.32898122731366,-0.67401540201882,"SEBOX///VTN","SEBOX homeobox///vitronectin",TRUE
+"204534_at",0.985425981490741,0.928904304140408,0.0902438231787137,-5.93571764244385,0.0762731634168636,"SEBOX///VTN","SEBOX homeobox///vitronectin",TRUE
+"201290_at",0.937113154905832,0.720901998829019,0.361836739808405,-5.87611475332871,0.142281088440487,"SEC11A","SEC11 homolog A, signal peptidase complex subunit",TRUE
+"216274_s_at",0.961399154864413,0.825124759366678,0.223590350955928,-5.9153631986979,0.0912351025175564,"SEC11A","SEC11 homolog A, signal peptidase complex subunit",TRUE
+"223299_at",0.664177276170497,0.132239160219966,-1.56293461271233,-4.81516758672175,-0.712840599259467,"SEC11C","SEC11 homolog C, signal peptidase complex subunit",TRUE
+"235676_at",0.991363846997029,0.959542291414408,-0.0513049031570339,-5.938401517863,-0.0336010508758351,"SEC11C","SEC11 homolog C, signal peptidase complex subunit",TRUE
+"207707_s_at",0.728385463227073,0.208709476808337,-1.29483185725555,-5.15449134999576,-0.406639038541734,"SEC13","SEC13 homolog, nuclear pore and COPII coat complex component",TRUE
+"202082_s_at",0.827866702343255,0.397176050519306,0.863384660892753,-5.58298966697765,0.473292061480057,"SEC14L1","SEC14 like lipid binding 1",TRUE
+"240036_at",0.918409982899324,0.653499604642573,-0.455051644591032,-5.83932652896224,-0.294793106766419,"SEC14L1","SEC14 like lipid binding 1",TRUE
+"202084_s_at",0.930527241884777,0.692608356593428,-0.400521343617121,-5.86185071202713,-0.217525383928864,"SEC14L1","SEC14 like lipid binding 1",TRUE
+"202083_s_at",0.980053432264641,0.906327602051482,0.11902566515331,-5.93278555919747,0.0807818681517585,"SEC14L1","SEC14 like lipid binding 1",TRUE
+"217667_at",0.947001578829888,0.759367297329652,-0.310120762797724,-5.89294849643874,-0.26542061309472,"SEC14L1P1","SEC14 like 1 pseudogene 1",TRUE
+"232895_s_at",0.6936485676385,0.162697548255665,1.44412175432575,-4.97196500469857,1.06859559346994,"SEC14L2","SEC14 like lipid binding 2",TRUE
+"232894_at",0.862125670830879,0.48496361554655,0.710241128775277,-5.69693026949456,0.33249688366568,"SEC14L2","SEC14 like lipid binding 2",TRUE
+"230316_at",0.879419229950485,0.53365876146829,-0.632305028975299,-5.74680486944284,-0.648182559696745,"SEC14L2","SEC14 like lipid binding 2",TRUE
+"240024_at",0.926430328514448,0.680142306178822,-0.417761429132961,-5.85503462871726,-0.52931381166249,"SEC14L2","SEC14 like lipid binding 2",TRUE
+"204541_at",0.989586772349659,0.949476696789802,0.0640856554545876,-5.93768332444505,0.0484468375516807,"SEC14L2","SEC14 like lipid binding 2",TRUE
+"241221_at",0.820536502908875,0.379872038073117,0.896023968305264,-5.55602788830704,0.641992907736117,"SEC14L3","SEC14 like lipid binding 3",TRUE
+"216346_at",0.952293443370532,0.78163673754636,-0.280578705113964,-5.90141229737719,-0.14248421092465,"SEC14L3","SEC14 like lipid binding 3",TRUE
+"240699_at",0.95915232180739,0.814868743507677,0.23695507529593,-5.9123729446307,0.107326636632083,"SEC14L3","SEC14 like lipid binding 3",TRUE
+"239492_at",0.307916971162643,0.00619927418943398,3.02440238877552,-2.25851936567229,1.06158374039542,"SEC14L4","SEC14 like lipid binding 4",TRUE
+"216402_at",0.65284137151906,0.121922083822468,1.60832256092787,-4.75268865878149,1.06518116960663,"SEC14L4","SEC14 like lipid binding 4",TRUE
+"210169_at",0.656641058207682,0.124632364397261,1.59609861808911,-4.76965276111651,0.452192344428445,"SEC14L5","SEC14 like lipid binding 5",TRUE
+"215696_s_at",0.396045922266519,0.0136035526660544,-2.68080311428925,-2.93938109093123,-1.14324505780413,"SEC16A","SEC16 homolog A, endoplasmic reticulum export factor",TRUE
+"228150_at",0.369687273960354,0.0111095850508598,2.77060684150064,-2.76479831657178,2.04539417902284,"SEC16B","SEC16 homolog B, endoplasmic reticulum export factor",TRUE
+"1564423_a_at",0.415590231477955,0.0168896478160771,2.58371014725502,-3.12507789864248,1.03369697022594,"SEC16B","SEC16 homolog B, endoplasmic reticulum export factor",TRUE
+"1552880_at",0.754513748034606,0.247818794426697,1.18694809397314,-5.27583794315422,1.29998797327541,"SEC16B","SEC16 homolog B, endoplasmic reticulum export factor",TRUE
+"239618_at",0.960475119626191,0.820501351849666,-0.229609859965179,-5.91403775107889,-0.226703570589129,"SEC16B","SEC16 homolog B, endoplasmic reticulum export factor",TRUE
+"1555289_at",0.974131902264546,0.874130835789432,0.160256833135405,-5.92718233854439,0.0523806235317794,"SEC16B","SEC16 homolog B, endoplasmic reticulum export factor",TRUE
+"237598_at",0.7768734672127,0.294806396449273,1.07302884811143,-5.39392335544858,0.810247901153151,"SEC1P","secretory blood group 1, pseudogene",TRUE
+"218703_at",0.7995040428866,0.334984870046293,-0.985570460277769,-5.47733541546837,-0.320728134929018,"SEC22A","SEC22 homolog A, vesicle trafficking protein",TRUE
+"238078_at",0.912252515563073,0.632499709929404,-0.48491018918342,-5.82580090068842,-0.303799184587076,"SEC22A","SEC22 homolog A, vesicle trafficking protein",TRUE
+"233020_at",0.294892467696083,0.00523174565459901,-3.0970739672536,-2.11049004984142,-2.1648224285027,"SEC22B","SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)",TRUE
+"214257_s_at",0.789795896476304,0.318525776278818,-1.02045622457403,-5.44483101774612,-0.334374304854911,"SEC22B","SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)",TRUE
+"225460_at",0.768852835478002,0.271982694953907,-1.12655948256351,-5.33974519423645,-0.474500654939213,"SEC22C","SEC22 homolog C, vesicle trafficking protein",TRUE
+"224470_at",0.799008022536007,0.33366165835468,-0.988330591390007,-5.47480110302983,-0.38315585175132,"SEC22C","SEC22 homolog C, vesicle trafficking protein",TRUE
+"235120_at",0.812302873476553,0.359119704932382,-0.936484781154515,-5.52132303762555,-0.26471250882876,"SEC22C","SEC22 homolog C, vesicle trafficking protein",TRUE
+"239056_at",0.829272826611461,0.400492894132156,-0.857234160763736,-5.58796618318122,-0.300191937663429,"SEC22C","SEC22 homolog C, vesicle trafficking protein",TRUE
+"236268_at",0.880685398344064,0.536184183816772,0.628372552185815,-5.7491741015491,0.268064162168137,"SEC22C","SEC22 homolog C, vesicle trafficking protein",TRUE
+"239013_at",0.893635948253276,0.569115751589923,-0.577965083903114,-5.77827985455542,-0.351356834754274,"SEC22C","SEC22 homolog C, vesicle trafficking protein",TRUE
+"204344_s_at",0.721907781985393,0.19815503550778,-1.32659264055274,-5.11705482550215,-0.543123203291641,"SEC23A","Sec23 homolog A, coat complex II component",TRUE
+"212887_at",0.980335118024956,0.908338936008123,0.116457706453139,-5.93307989520579,0.0432221945801405,"SEC23A","Sec23 homolog A, coat complex II component",TRUE
+"201582_at",0.617775129514679,0.0885669866384,-1.78136635737233,-4.5020588110047,-0.844480269170878,"SEC23B","Sec23 homolog B, coat complex II component",TRUE
+"201583_s_at",0.709158363400091,0.181914814995645,-1.37815503663019,-5.0546584759735,-0.521534262711024,"SEC23B","Sec23 homolog B, coat complex II component",TRUE
+"210293_s_at",0.860085676417428,0.47932697065821,-0.719544685424454,-5.69060730034609,-0.231872309097449,"SEC23B","Sec23 homolog B, coat complex II component",TRUE
+"216392_s_at",0.931455521649454,0.696951904722069,0.394543543184348,-5.86414808802175,0.266621722350351,"SEC23IP","SEC23 interacting protein",TRUE
+"209176_at",0.9330573785522,0.704353954122502,0.38438996279442,-5.86797227703215,0.15224443980671,"SEC23IP","SEC23 interacting protein",TRUE
+"209175_at",0.945272089973488,0.752918883322606,-0.318726722828754,-5.8903250970711,-0.131125277428968,"SEC23IP","SEC23 interacting protein",TRUE
+"1558919_a_at",0.991689960875868,0.961460323563567,-0.0488705485888231,-5.93852027995966,-0.0343460556874682,"SEC23IP","SEC23 interacting protein",TRUE
+"212902_at",0.77340139236553,0.284747244014894,-1.09623796820884,-5.37072149579064,-0.3848572959373,"SEC24A","SEC24 homolog A, COPII coat complex component",TRUE
+"212900_at",0.774230543658252,0.287971979817576,-1.08873424648371,-5.37827129241303,-0.372916159279477,"SEC24A","SEC24 homolog A, COPII coat complex component",TRUE
+"244841_at",0.778686132916778,0.29965722305562,-1.06203934264226,-5.40475457399133,-0.386720967556828,"SEC24A","SEC24 homolog A, COPII coat complex component",TRUE
+"202798_at",0.882420879090034,0.540035553752315,-0.622394494292112,-5.75274849179674,-0.184392375308034,"SEC24B","SEC24 homolog B, COPII coat complex component",TRUE
+"1569713_at",0.590570903980459,0.0683058339811556,-1.91638008579729,-4.2936132550775,-0.574799635360753,"SEC24B-AS1","SEC24B antisense RNA 1",TRUE
+"202361_at",0.997416572515028,0.986927052090773,-0.0165711563238925,-5.93954973252929,-0.00565628864049827,"SEC24C","SEC24 homolog C, COPII coat complex component",TRUE
+"215641_at",0.713330901550199,0.188171636665864,1.35787617997471,-5.07943540849324,0.647490754027523,"SEC24D","SEC24 homolog D, COPII coat complex component",TRUE
+"202375_at",0.841405763268593,0.432021655093539,-0.80032306906694,-5.63243568460313,-0.292370566767875,"SEC24D","SEC24 homolog D, COPII coat complex component",TRUE
+"215209_at",0.859947009633611,0.47840676216981,-0.721069571265868,-5.68956347617228,-0.632638224602101,"SEC24D","SEC24 homolog D, COPII coat complex component",TRUE
+"200945_s_at",0.92777930247318,0.683143681064203,0.413599054092876,-5.85670615035729,0.12758250518177,"SEC31A","SEC31 homolog A, COPII coat complex component",TRUE
+"210616_s_at",0.960116489822537,0.819364384668283,0.231091471162398,-5.91370613964419,0.0780640817834044,"SEC31A","SEC31 homolog A, COPII coat complex component",TRUE
+"209889_at",0.805746717966166,0.3454297829962,0.96404150265876,-5.4968812071104,0.601100737689237,"SEC31B","SEC31 homolog B, COPII coat complex component",TRUE
+"217716_s_at",0.777463110382572,0.296410032664375,-1.06938161813826,-5.39752911684623,-0.230894804470287,"SEC61A1","Sec61 translocon alpha 1 subunit",TRUE
+"222385_x_at",0.985361089461736,0.927235859800948,-0.0923678596507093,-5.93552879927412,-0.0260388633634214,"SEC61A1","Sec61 translocon alpha 1 subunit",TRUE
+"219499_at",0.407748633394319,0.0155650284121164,-2.62050818683489,-3.05508896880552,-0.937759783947756,"SEC61A2","Sec61 translocon alpha 2 subunit",TRUE
+"230215_at",0.424084762414675,0.017925192243993,-2.55678131729614,-3.17598395380906,-1.11709883469601,"SEC61A2","Sec61 translocon alpha 2 subunit",TRUE
+"228747_at",0.953983577550391,0.787999748432245,-0.272185488268076,-5.90366371904945,-0.0697527355261212,"SEC61A2","Sec61 translocon alpha 2 subunit",TRUE
+"244700_at",0.991754150288374,0.961767175175772,-0.0484811228884588,-5.93853874301976,-0.0210551973447979,"SEC61B","Sec61 translocon beta subunit",TRUE
+"203133_at",0.994050962712312,0.972166283909469,-0.0352877439973705,-5.9390769958226,-0.0118735568974166,"SEC61B","Sec61 translocon beta subunit",TRUE
+"203484_at",0.921462951426584,0.665251568523092,0.438525430774566,-5.84645060053968,0.148647124712205,"SEC61G","Sec61 translocon gamma subunit",TRUE
+"208943_s_at",0.909253608893833,0.623302391065371,-0.49812782807906,-5.81954518245073,-0.17874623603233,"SEC62","SEC62 homolog, preprotein translocation factor",TRUE
+"1552789_at",0.945498722604777,0.753586643138337,-0.317834410730203,-5.89060040972391,-0.226614589158509,"SEC62","SEC62 homolog, preprotein translocation factor",TRUE
+"208942_s_at",0.94630837494651,0.756960344494876,-0.313330217014689,-5.89197845831652,-0.111131800602944,"SEC62","SEC62 homolog, preprotein translocation factor",TRUE
+"1552790_a_at",0.954577684533304,0.792633437368723,-0.266085936024625,-5.90525728644405,-0.120224751361947,"SEC62","SEC62 homolog, preprotein translocation factor",TRUE
+"225352_at",0.986342822130003,0.934451671230295,-0.0831846707064917,-5.93631371707055,-0.0329512697965928,"SEC62","SEC62 homolog, preprotein translocation factor",TRUE
+"235395_at",0.735888612172922,0.220988662519748,1.25940916821217,-5.19533349947644,0.755921414385564,"SEC63","SEC63 homolog, protein translocation regulator",TRUE
+"201914_s_at",0.852371612067119,0.458106815741284,0.755158244778075,-5.66568160079901,0.237647623043777,"SEC63","SEC63 homolog, protein translocation regulator",TRUE
+"201916_s_at",0.896118635245982,0.578045534574466,0.564558333559779,-5.78562480205048,0.159111539591091,"SEC63","SEC63 homolog, protein translocation regulator",TRUE
+"229969_at",0.951086326184662,0.776542198211422,0.287313567831221,-5.89955665232379,0.103150788107564,"SEC63","SEC63 homolog, protein translocation regulator",TRUE
+"201915_at",0.952080564002327,0.780714769208602,0.281796534804328,-5.90107998562488,0.103277897275712,"SEC63","SEC63 homolog, protein translocation regulator",TRUE
+"218265_at",0.614034563169767,0.0850039038503994,-1.80301774047457,-4.46936727989541,-0.700254060157988,"SECISBP2","SECIS binding protein 2",TRUE
+"224250_s_at",0.890302070370912,0.558671425353355,-0.593782807448591,-5.76939952893079,-0.234081937660042,"SECISBP2","SECIS binding protein 2",TRUE
+"212450_at",0.255716413540338,0.00369863720011651,-3.24427075179567,-1.80713585311009,-1.4819543953661,"SECISBP2L","SECIS binding protein 2 like",TRUE
+"212451_at",0.723649742218726,0.200213453642761,-1.32029667592466,-5.12453678244676,-0.646907415848882,"SECISBP2L","SECIS binding protein 2 like",TRUE
+"213716_s_at",0.929898479966654,0.690463440168381,0.403478753927431,-5.86070154898997,0.462838513569311,"SECTM1","secreted and transmembrane 1",TRUE
+"223225_s_at",0.288135719419258,0.00493269379746548,3.12217743437383,-2.05907584398141,1.36882462798352,"SEH1L","SEH1 like nucleoporin",TRUE
+"221931_s_at",0.384135218769668,0.0124246427562965,2.72112099446304,-2.86132412558865,1.15263378236763,"SEH1L","SEH1 like nucleoporin",TRUE
+"202064_s_at",0.78226567430527,0.304442996711051,-1.05132080433192,-5.41522241579408,-0.441133914612932,"SEL1L","SEL1L ERAD E3 ligase adaptor subunit",TRUE
+"202061_s_at",0.859544466207891,0.47753594605279,-0.722514187008107,-5.6885726606806,-0.299064531988877,"SEL1L","SEL1L ERAD E3 ligase adaptor subunit",TRUE
+"202063_s_at",0.914588178928864,0.640227019563763,-0.473872551923852,-5.83089882772047,-0.318341434336507,"SEL1L","SEL1L ERAD E3 ligase adaptor subunit",TRUE
+"202062_s_at",0.990810941805126,0.95544689506943,-0.0565038377386954,-5.938128561878,-0.0293912041614384,"SEL1L","SEL1L ERAD E3 ligase adaptor subunit",TRUE
+"234018_s_at",0.910860516303107,0.628109600927649,0.491208225848839,-5.82284062886224,0.432659947846492,"SEL1L2","SEL1L2 ERAD E3 ligase adaptor subunit",TRUE
+"209631_s_at",0.976392182310915,0.887473656872424,0.143139683139466,-5.92970898396183,0.182767265939937,"SEL1L2///GPR37","SEL1L2 ERAD E3 ligase adaptor subunit///G protein-coupled receptor 37",TRUE
+"212311_at",0.211717781026763,0.00246890519245129,3.41395534895122,-1.45243331086422,2.56736394661851,"SEL1L3","SEL1L family member 3",TRUE
+"212314_at",0.380731642340006,0.0118762866543529,2.74112257353932,-2.82240333316567,3.16028845006816,"SEL1L3","SEL1L family member 3",TRUE
+"235353_at",0.662575055303091,0.130298355122994,1.57124250917481,-4.80383597421483,0.864783669342466,"SEL1L3","SEL1L family member 3",TRUE
+"230232_at",0.710824498521146,0.184095182706385,1.3710265415596,-5.06340300006137,1.00810997732042,"SEL1L3","SEL1L family member 3",TRUE
+"206211_at",0.67966398171993,0.146996370989267,-1.50285526669,-4.8956951477014,-1.40708474140541,"SELE","selectin E",TRUE
+"214433_s_at",0.46584896273628,0.0241820066090011,-2.41965069522061,-3.43090136040185,-3.20101004728841,"SELENBP1","selenium binding protein 1",TRUE
+"223070_at",0.857381762624307,0.472871432519015,-0.73027864321739,-5.6832149858194,-0.233394688765665,"SELK","selenoprotein K",TRUE
+"204563_at",0.553930058946379,0.0506676070893944,-2.06647147485758,-4.04966569481841,-1.35940115101841,"SELL","selectin L",TRUE
+"226051_at",0.955892698633978,0.799265583594355,0.257373563897139,-5.90747126040863,0.419018803860411,"SELM","selenoprotein M",TRUE
+"233168_s_at",0.966593471043185,0.844333488731617,-0.198668834237613,-5.9204777011518,-0.0768672650836901,"SELO","selenoprotein O",TRUE
+"233167_at",0.974871801904735,0.876769476269987,-0.156868066692531,-5.92770513323532,-0.0909823087421238,"SELO","selenoprotein O",TRUE
+"206049_at",0.664094349733756,0.132083061099858,1.56359906931577,-4.81426303359674,0.530872866517605,"SELP","selectin P",TRUE
+"209879_at",0.64513208805899,0.116108417719034,1.63532956518047,-4.71485439269974,0.911478602738789,"SELPLG","selectin P ligand",TRUE
+"209880_s_at",0.867159108376357,0.499207124197626,0.68700599573267,-5.7123788508248,0.462562182580665,"SELPLG","selectin P ligand",TRUE
+"217811_at",0.812302873476553,0.357177015229095,0.940351558213374,-5.51793254630739,0.36942642815711,"SELT","selenoprotein T",TRUE
+"225561_at",0.957017346544368,0.80549171980493,0.249213047349898,-5.90947857345884,0.121431344060857,"SELT","selenoprotein T",TRUE
+"206805_at",0.152865811663982,0.00111769382910652,3.74235255519203,-0.754685185913575,2.87198942558025,"SEMA3A","semaphorin 3A",TRUE
+"244849_at",0.152865811663982,0.00112954344604022,3.73801091199737,-0.763982799745338,3.78477672856444,"SEMA3A","semaphorin 3A",TRUE
+"244163_at",0.238811487311851,0.00316066072905454,3.3104760212164,-1.66932307650722,3.5865470020028,"SEMA3A","semaphorin 3A",TRUE
+"203070_at",0.62601605985821,0.0969781040941338,1.73308395314479,-4.57391559180097,0.909308652765244,"SEMA3B","semaphorin 3B",TRUE
+"203788_s_at",0.841922802269752,0.434196566174672,-0.796494580007363,-5.63532437817058,-0.506475298878394,"SEMA3C","semaphorin 3C",TRUE
+"203789_s_at",0.897981316197267,0.586812518452897,-0.551496951397881,-5.79261973599419,-0.386515925489634,"SEMA3C","semaphorin 3C",TRUE
+"215643_at",0.748632141741128,0.241509129097671,1.20343469468292,-5.25788438842606,0.982139128168352,"SEMA3D","semaphorin 3D",TRUE
+"215324_at",0.986249924471866,0.932524951955104,0.0856359558365571,-5.93611222616976,0.0914585488455137,"SEMA3D","semaphorin 3D",TRUE
+"206941_x_at",0.933649615158206,0.706401544373462,-0.381588525895933,-5.86901009632492,-0.484491648361951,"SEMA3E","semaphorin 3E",TRUE
+"35666_at",0.580630437263151,0.0632474239609774,-1.95553226648888,-4.23117846518263,-1.42824156703259,"SEMA3F","semaphorin 3F",TRUE
+"206832_s_at",0.756584150514497,0.251931797791805,-1.1763696176386,-5.28724393764504,-1.41938099042074,"SEMA3F","semaphorin 3F",TRUE
+"209730_at",0.871744769522775,0.514104523737684,-0.663103411931418,-5.72775856561324,-0.596418787346439,"SEMA3F","semaphorin 3F",TRUE
+"219689_at",0.638101654979046,0.109276609827353,-1.66855819392962,-4.66764194567463,-1.04818881834566,"SEMA3G","semaphorin 3G",TRUE
+"219259_at",0.886916043359667,0.550542855179624,-0.606199805110144,-5.76226611411307,-0.45686204926788,"SEMA4A","semaphorin 4A",TRUE
+"234072_at",0.912252515563073,0.632497035856155,0.484914019327031,-5.82579911174897,0.166882263861827,"SEMA4A","semaphorin 4A",TRUE
+"234725_s_at",0.850206060456713,0.452845370564296,0.764139801924156,-5.6592154559932,0.507022734797916,"SEMA4B","semaphorin 4B",TRUE
+"46665_at",0.722314275419786,0.198769983468505,-1.32470640513599,-5.11929952438283,-0.84526336277928,"SEMA4C","semaphorin 4C",TRUE
+"219039_at",0.774230543658252,0.287680259499405,-1.08941055608617,-5.37759272407836,-0.630610095694108,"SEMA4C","semaphorin 4C",TRUE
+"203528_at",0.980832655742,0.910156380181905,0.114137985549574,-5.93334026701577,0.0443877361278524,"SEMA4D","semaphorin 4D",TRUE
+"228891_at",0.989654520357877,0.950171738036202,0.0632028026706411,-5.93773804843901,0.0548772485411417,"SEMA4D","semaphorin 4D",TRUE
+"208124_s_at",0.442317261108644,0.0205160781741476,2.49529891328082,-3.29118824444126,0.899763805918699,"SEMA4F","ssemaphorin 4F",TRUE
+"228660_x_at",0.533322160593079,0.0421390349110581,2.15671292853217,-3.89723355544291,0.780092424458786,"SEMA4F","ssemaphorin 4F",TRUE
+"210124_x_at",0.535697382361465,0.0429751521674182,2.14717175994857,-3.91354513786473,0.649514361149212,"SEMA4F","ssemaphorin 4F",TRUE
+"203483_at",0.711941360044137,0.185593053584071,-1.36616802528848,-5.06934131410496,-0.58560999695799,"SEMA4G","semaphorin 4G",TRUE
+"219194_at",0.99783553534859,0.98935197319502,0.0134971298873032,-5.93959475162309,0.00498378937895883,"SEMA4G","semaphorin 4G",TRUE
+"229427_at",0.896229101808264,0.579835068317865,0.561884219384337,-5.78706983683506,0.554729963728549,"SEMA5A","semaphorin 5A",TRUE
+"213169_at",0.961697107105026,0.826517663276038,0.221778505651839,-5.91575529186612,0.19472344274902,"SEMA5A","semaphorin 5A",TRUE
+"205405_at",0.987631453197548,0.941569080894782,0.074133890765564,-5.93700701723092,0.102678875148014,"SEMA5A","semaphorin 5A",TRUE
+"223610_at",0.851733415458562,0.455944448697484,0.758841966910418,-5.66303830336478,0.335555905523499,"SEMA5B","semaphorin 5B",TRUE
+"220454_s_at",0.655745626967443,0.124145582238909,-1.59827766442466,-4.76663609885274,-0.907438586031954,"SEMA6A","semaphorin 6A",TRUE
+"1558338_at",0.670164229230396,0.136004869795749,-1.54709861758016,-4.83663610725532,-0.630818685410603,"SEMA6A","semaphorin 6A",TRUE
+"225660_at",0.68578004197551,0.154139020317093,-1.47553533205185,-4.93147771250093,-2.0976482665151,"SEMA6A","semaphorin 6A",TRUE
+"215028_at",0.697172073261335,0.167541518919329,-1.42692901176724,-4.99382306371362,-1.74890747398503,"SEMA6A","semaphorin 6A",TRUE
+"223449_at",0.826161156561654,0.394366347052631,-0.868620711621218,-5.57872697437135,-0.925264572737638,"SEMA6A","semaphorin 6A",TRUE
+"224182_x_at",0.724067243569133,0.201169193872208,-1.31739057011089,-5.12798019453749,-0.532523017507613,"SEMA6B","semaphorin 6B",TRUE
+"223567_at",0.812302873476553,0.359793528604878,-0.935146870120738,-5.5224931651996,-0.86917959929352,"SEMA6B","semaphorin 6B",TRUE
+"220778_x_at",0.935414597731663,0.712814529693928,-0.372834480957292,-5.87220486225148,-0.124005596546364,"SEMA6B","semaphorin 6B",TRUE
+"208100_x_at",0.684141430407459,0.153032458964485,-1.47969942790822,-4.92605790554734,-0.859715434045127,"SEMA6C","semaphorin 6C",TRUE
+"226492_at",0.364513221153898,0.0106287329526601,-2.79009964837536,-2.72656545632816,-1.44150026718842,"SEMA6D","semaphorin 6D",TRUE
+"233882_s_at",0.755868740464627,0.250383442467324,1.18033668599439,-5.28297698587924,0.771313184307763,"SEMA6D","semaphorin 6D",TRUE
+"244746_at",0.827985973549523,0.397577386376615,0.862638700319811,-5.58359500581522,0.5721892787146,"SEMA6D","semaphorin 6D",TRUE
+"220574_at",0.857381762624307,0.472840887629059,0.730329635500333,-5.68317962001024,0.470914690221644,"SEMA6D","semaphorin 6D",TRUE
+"233801_s_at",0.920147736488699,0.660055417449136,0.445816952806574,-5.84333925780135,0.337174254823729,"SEMA6D","semaphorin 6D",TRUE
+"230345_at",0.519956259865057,0.0375874297316144,2.21187020798303,-3.80206025335907,1.96849481177994,"SEMA7A","semaphorin 7A (John Milton Hagen blood group)",TRUE
+"210083_at",0.790333400800316,0.320007331082165,1.01726532478262,-5.44784664734911,0.555415915972224,"SEMA7A","semaphorin 7A (John Milton Hagen blood group)",TRUE
+"206442_at",0.857913750327589,0.473574666641737,0.729105184690657,-5.68402819252269,0.543520926674685,"SEMG1","semenogelin I",TRUE
+"216030_s_at",0.637485146909712,0.108846232753663,1.67070957485588,-4.66456024854336,1.15124531599952,"SEMG2","semenogelin II",TRUE
+"239641_at",0.935229311206739,0.71174927552469,-0.374286533882068,-5.87167999899929,-0.213499988215572,"SENCR","smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA",TRUE
+"226619_at",0.673366993714442,0.139613742213206,-1.53225810165624,-4.85659807116169,-0.391646002780488,"SENP1","SUMO1/sentrin specific peptidase 1",TRUE
+"1552812_a_at",0.78638420006208,0.311819256543542,-1.03503201054054,-5.4309474331619,-0.285434642714803,"SENP1","SUMO1/sentrin specific peptidase 1",TRUE
+"218122_s_at",0.527954898603995,0.0405079250049156,2.17582925235042,-3.86441670177077,0.547492777401729,"SENP2","SUMO1/sentrin/SMT3 specific peptidase 2",TRUE
+"222523_at",0.643688366500038,0.114617343505353,1.64243868266648,-4.70481460822718,0.530492126881992,"SENP2","SUMO1/sentrin/SMT3 specific peptidase 2",TRUE
+"228380_at",0.725225714005638,0.204022474478041,1.3087781655404,-5.13814728499604,0.381657345758398,"SENP2","SUMO1/sentrin/SMT3 specific peptidase 2",TRUE
+"215114_at",0.823222990223616,0.389997656932274,0.876810188862446,-5.57201186873276,0.421370523342226,"SENP3","SUMO1/sentrin/SMT3 specific peptidase 3",TRUE
+"203871_at",0.897699110987203,0.584900666595289,0.554336964556158,-5.79111230594755,0.156198616419285,"SENP3","SUMO1/sentrin/SMT3 specific peptidase 3",TRUE
+"215113_s_at",0.886940491679955,0.550706096233217,0.605949500802722,-5.76241131855334,0.200622759704133,"SENP3-EIF4A1///SENP3","SENP3-EIF4A1 readthrough (NMD candidate)///SUMO1/sentrin/SMT3 specific peptidase 3",TRUE
+"222110_at",0.753473040538864,0.246706435696877,1.18983155757641,-5.2727134714904,0.322404245388618,"SENP5","SUMO1/sentrin specific peptidase 5",TRUE
+"57703_at",0.894737148770801,0.572045056136366,0.573555484301208,-5.78071410470703,0.194072182789316,"SENP5","SUMO1/sentrin specific peptidase 5",TRUE
+"213184_at",0.937462538530338,0.722724482759224,0.359364749717218,-5.87697768045322,0.103974535844447,"SENP5","SUMO1/sentrin specific peptidase 5",TRUE
+"202318_s_at",0.886783047600321,0.550277694190066,0.606606470751002,-5.76203007924525,0.191549192583578,"SENP6","SUMO1/sentrin specific peptidase 6",TRUE
+"214790_at",0.943988850936011,0.749819964006993,-0.322871208374298,-5.88903634544615,-0.120425061755434,"SENP6","SUMO1/sentrin specific peptidase 6",TRUE
+"202319_at",0.966313390701604,0.84295357824087,0.200454661872115,-5.92013120442355,0.0782720984498955,"SENP6","SUMO1/sentrin specific peptidase 6",TRUE
+"223444_at",0.581128536542197,0.063612270642695,-1.95261765681627,-4.23585613461676,-0.809178958311512,"SENP7","SUMO1/sentrin specific peptidase 7",TRUE
+"220735_s_at",0.66821692116892,0.134318617809488,-1.55414445114194,-4.8271055109976,-0.518452400881267,"SENP7","SUMO1/sentrin specific peptidase 7",TRUE
+"228398_at",0.751464513744428,0.244623479190781,-1.1952573051316,-5.26681632523513,-0.422830797835427,"SENP8","SUMO/sentrin peptidase family member, NEDD8 specific",TRUE
+"1552684_a_at",0.791838559691106,0.322589396567008,-1.01172878147255,-5.45305880244815,-0.320556797961293,"SENP8","SUMO/sentrin peptidase family member, NEDD8 specific",TRUE
+"200902_at",0.890053107059168,0.558352656955142,-0.594267967397005,-5.76912348796563,-0.142738826881965,"SEP15","15 kDa selenoprotein",TRUE
+"208941_s_at",0.806216644294069,0.346699230592158,0.961455394238564,-5.49920257587132,0.348070880892866,"SEPHS1","selenophosphate synthetase 1",TRUE
+"208939_at",0.943796292994499,0.748201308158273,0.325038285102395,-5.88835591782725,0.0987080451322182,"SEPHS1","selenophosphate synthetase 1",TRUE
+"208940_at",0.97304633500821,0.869371662303232,0.166373857620923,-5.92621043252478,0.0507686080413823,"SEPHS1","selenophosphate synthetase 1",TRUE
+"200961_at",0.488449738418647,0.0290613077105781,-2.33397392682214,-3.58626882659108,-1.13456928296447,"SEPHS2","selenophosphate synthetase 2",TRUE
+"224659_at",0.908013878860707,0.618403785406163,0.505204440401114,-5.81612841807678,0.187039515027463,"SEPN1","selenoprotein N, 1",TRUE
+"201427_s_at",0.612420348961838,0.084175419778517,-1.80816416890688,-4.46155452799431,-4.12722384622119,"SEPP1","selenoprotein P, plasma, 1",TRUE
+"229620_at",0.671298718565642,0.137295327642416,-1.54175509725883,-4.84384122815963,-2.0263050160351,"SEPP1","selenoprotein P, plasma, 1",TRUE
+"231669_at",0.710672261019989,0.183763415214413,-1.37210689504608,-5.06208015513851,-1.68062347422046,"SEPP1","selenoprotein P, plasma, 1",TRUE
+"235516_at",0.485891214889727,0.0285891547928716,-2.34165959117794,-3.57246059179727,-0.888517234849361,"SEPSECS","Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase",TRUE
+"227982_at",0.593339168375633,0.0705166986139775,-1.90006383333395,-4.31937412791706,-1.21393228198929,"SEPSECS","Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase",TRUE
+"1569634_at",0.647518308302168,0.118546085789725,-1.62387066643189,-4.73096659606797,-1.04274663763838,"SEPSECS","Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase",TRUE
+"231730_at",0.909052380289506,0.622652352603609,-0.499065395035595,-5.81909520546414,-0.185021903826907,"SEPSECS","Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase",TRUE
+"1553167_a_at",0.979588787486838,0.901877661616994,-0.124710040606465,-5.93211122340915,-0.0458022706683128,"SEPSECS","Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase",TRUE
+"1559479_at",0.86163303664609,0.48226235367981,0.714691806401822,-5.69391523050616,0.457113810934963,"SEPSECS-AS1","SEPSECS antisense RNA 1 (head to head)",TRUE
+"222631_at",0.951934441578502,0.780246731868294,0.282414932675929,-5.90091069532955,0.084483626845099,"SEPSECS-AS1///PI4K2B","SEPSECS antisense RNA 1 (head to head)///phosphatidylinositol 4-kinase type 2 beta",TRUE
+"227552_at",0.739340500562926,0.226533699804619,-1.24390672453228,-5.21290253752195,-1.27245473848294,"SEPT1","septin 1",TRUE
+"214720_x_at",0.835838027302116,0.415480675007168,0.829840763102389,-5.60972761465619,0.43718550220779,"SEPT10","septin 10",TRUE
+"212698_s_at",0.860085676417428,0.479288771886716,0.719607950950076,-5.69056403523202,0.412440000309129,"SEPT10","septin 10",TRUE
+"214293_at",0.709158363400091,0.18185584553233,1.37834876947975,-5.05442029796896,0.828961133353044,"SEPT11","septin 11",TRUE
+"201308_s_at",0.85334340854827,0.461011954881269,0.750225537026827,-5.66920205530393,0.851971667935032,"SEPT11","septin 11",TRUE
+"201307_at",0.863982129426672,0.490435724511497,0.701268856164516,-5.70295383402276,0.627113167655695,"SEPT11","septin 11",TRUE
+"230071_at",0.925091998149497,0.675980867365858,0.423545068749299,-5.85268472330103,0.381137717353632,"SEPT11","septin 11",TRUE
+"230947_at",0.629621797906838,0.100634278478988,1.71320707830537,-4.60307178318562,0.8630140391372,"SEPT12","septin 12",TRUE
+"1554747_a_at",0.760325881249847,0.259002359949113,-1.15848115527648,-5.30632842113973,-0.332629519466947,"SEPT2","septin 2",TRUE
+"200778_s_at",0.769847953580141,0.278203842217842,-1.11165507731661,-5.35506511299399,-0.305552714938939,"SEPT2","septin 2",TRUE
+"200015_s_at",0.773657212801073,0.285097760349167,-1.09541937891808,-5.3715473547004,-0.297846872342898,"SEPT2","septin 2",TRUE
+"232637_at",0.89390639630277,0.569571311738173,0.577278552829682,-5.77866002986732,0.213205482418763,"SEPT2","septin 2",TRUE
+"1559038_at",0.899798994481376,0.591669458322406,0.544302579950774,-5.79640472653995,0.297482709536011,"SEPT2","septin 2",TRUE
+"223362_s_at",0.776936981479994,0.295342513685905,-1.07180795338882,-5.39513159143737,-0.810515345944239,"SEPT3","septin 3",TRUE
+"210657_s_at",0.711720566366182,0.185193217943355,-1.36746189587268,-5.0677615979399,-1.17929132238725,"SEPT4","septin 4",TRUE
+"210348_at",0.863918945062466,0.490237051612534,-0.70159359560456,-5.70273709234882,-0.475222557701909,"SEPT4","septin 4",TRUE
+"233006_at",0.89203601623083,0.562310813708867,-0.588253861864933,-5.77252993159566,-0.222907501832687,"SEPT4","septin 4",TRUE
+"209768_s_at",0.908641534736832,0.619867590028745,0.503087078693644,-5.81715566439851,0.453364834522981,"SEPT5-GP1BB","SEPT5-GP1BB readthrough",TRUE
+"209769_s_at",0.975159323713639,0.878927986705834,-0.154097323695238,-5.9281243008606,-0.0473562302551462,"SEPT5-GP1BB","SEPT5-GP1BB readthrough",TRUE
+"206655_s_at",0.805746717966166,0.345963002074788,-0.962954446136485,-5.49785767610765,-1.44890260032564,"SEPT5-GP1BB///SEPT5///GP1BB","SEPT5-GP1BB readthrough///septin 5///glycoprotein Ib platelet beta subunit",TRUE
+"209767_s_at",0.972022150098794,0.865848184541765,-0.17090680393274,-5.92546679343668,-0.127567180089153,"SEPT5-GP1BB///SEPT5///GP1BB","SEPT5-GP1BB readthrough///septin 5///glycoprotein Ib platelet beta subunit",TRUE
+"213666_at",0.812302873476553,0.35955652326332,0.935617264260852,-5.52208193696505,0.518568857775067,"SEPT6","septin 6",TRUE
+"212413_at",0.879230721498488,0.533070309775096,0.633222781737314,-5.74624989648057,0.605976355140275,"SEPT6","septin 6",TRUE
+"214298_x_at",0.91876780831279,0.655093630347797,0.452802588218359,-5.84031123654503,0.46409591820984,"SEPT6","septin 6",TRUE
+"212415_at",0.937113154905832,0.720651587297169,-0.362176573519027,-5.8759956667902,-0.397706151466811,"SEPT6","septin 6",TRUE
+"1555526_a_at",0.980067566136987,0.906435075280161,-0.118888428768628,-5.932801451198,-0.108081304094288,"SEPT6","septin 6",TRUE
+"244508_at",0.745765373057882,0.23743096202686,1.21426365003612,-5.24597488785317,0.851571861397429,"SEPT7","septin 7",TRUE
+"217721_at",0.853768202875953,0.462523381248479,-0.747666595028891,-5.6710197551993,-0.311435408981293,"SEPT7","septin 7",TRUE
+"213151_s_at",0.934612165247339,0.709793747419688,-0.376954260812019,-5.8707104691894,-0.100592021948701,"SEPT7","septin 7",TRUE
+"1565823_at",0.979794616772313,0.90365866094398,0.122434489029292,-5.93238494141972,0.0648796028243757,"SEPT7","septin 7",TRUE
+"230450_at",0.728385463227073,0.208794526929232,-1.29458104171746,-5.15478392797942,-0.322912081257477,"SEPT7-AS1","SEPT7 antisense RNA 1 (head to head)",TRUE
+"228147_at",0.769258076576208,0.276632961967912,-1.11539541471904,-5.35123748516048,-0.695526458882767,"SEPT7P2","septin 7 pseudogene 2",TRUE
+"1569974_x_at",0.956960361976289,0.804888539136938,-0.250002863248925,-5.909287105073,-0.0892090371472767,"SEPT7P2","septin 7 pseudogene 2",TRUE
+"1569973_at",0.968262726161738,0.850607175958445,-0.190557902914085,-5.92201255182798,-0.0878846674270042,"SEPT7P2","septin 7 pseudogene 2",TRUE
+"230355_at",0.996261754016157,0.981467780268639,-0.0234924169273185,-5.93941467727386,-0.0146231415126046,"SEPT7P2","septin 7 pseudogene 2",TRUE
+"1556222_at",0.876862063516282,0.525903579664346,0.644444450565152,-5.7394014799178,0.228163722859254,"SEPT7P9","septin 7 pseudogene 9",TRUE
+"226627_at",0.531221788633914,0.041623303932468,2.16268374818828,-3.88700285431894,1.40451715291161,"SEPT8","septin 8",TRUE
+"208999_at",0.662575055303091,0.130433877145932,-1.57065906903194,-4.80463330116865,-0.691416773836549,"SEPT8","septin 8",TRUE
+"209000_s_at",0.928918075417927,0.686949145740705,-0.408332202270718,-5.85879760742339,-0.202037274858885,"SEPT8","septin 8",TRUE
+"207425_s_at",0.918141489589102,0.652384714200981,0.456626092300783,-5.83863434053757,0.354047219891108,"SEPT9","septin 9",TRUE
+"1559025_at",0.926735112907652,0.6808373434844,0.416796870262815,-5.85542344034677,0.170694654422799,"SEPT9","septin 9",TRUE
+"41220_at",0.955396260969248,0.795754961919762,0.261982740787885,-5.90630910448009,0.0785182016975607,"SEPT9","septin 9",TRUE
+"208657_s_at",0.959649219607517,0.817864566403621,-0.233046732878501,-5.91326526879009,-0.0899001793659,"SEPT9","septin 9",TRUE
+"201194_at",0.835952408568777,0.416586164967527,-0.827845253350886,-5.61128704706613,-0.312509938505372,"SEPW1","selenoprotein W, 1",TRUE
+"1555851_s_at",0.89980840440915,0.591758770870413,-0.544170558021782,-5.79647373265586,-0.17487545624463,"SEPW1","selenoprotein W, 1",TRUE
+"1569864_at",0.677013732819214,0.144049409689142,1.5144437159514,-4.88035811373261,1.19768064738128,"SERAC1","serine active site containing 1",TRUE
+"232183_at",0.789503009592599,0.316650025824449,1.02451106263341,-5.44098659111274,0.393102161176305,"SERAC1","serine active site containing 1",TRUE
+"217725_x_at",0.740476003158683,0.229391300685826,1.23603042695445,-5.22175711555587,0.336252624914902,"SERBP1","SERPINE1 mRNA binding protein 1",TRUE
+"209669_s_at",0.745235425991344,0.236904516731105,1.2156717464072,-5.24441949454554,0.392951435692375,"SERBP1","SERPINE1 mRNA binding protein 1",TRUE
+"210466_s_at",0.817055852876968,0.369435172931454,0.916183928629594,-5.5389124837123,0.332775849789178,"SERBP1","SERPINE1 mRNA binding protein 1",TRUE
+"227369_at",0.900692252557887,0.596063059429393,-0.53781947800105,-5.79977413710482,-0.181669431169398,"SERBP1","SERPINE1 mRNA binding protein 1",TRUE
+"228129_at",0.909304648717545,0.623427775586135,0.497947034885595,-5.8196318575398,0.178663196924466,"SERBP1","SERPINE1 mRNA binding protein 1",TRUE
+"210076_x_at",0.95388518141013,0.786992348390116,-0.273512967369176,-5.90331215071055,-0.0942413524000738,"SERBP1","SERPINE1 mRNA binding protein 1",TRUE
+"217724_at",0.978276691813018,0.895392414951135,0.133001922013705,-5.93107124309834,0.0313392581857403,"SERBP1","SERPINE1 mRNA binding protein 1",TRUE
+"223539_s_at",0.798428326317339,0.332868778838831,-0.989988102236135,-5.47327610254853,-0.429735256034554,"SERF1B///SERF1A","small EDRK-rich factor 1B///small EDRK-rich factor 1A",TRUE
+"223538_at",0.8080774583842,0.349853649704302,-0.955056997613535,-5.50492145684063,-0.404995531255453,"SERF1B///SERF1A","small EDRK-rich factor 1B///small EDRK-rich factor 1A",TRUE
+"219982_s_at",0.90115698600215,0.597609692455314,-0.535542852339315,-5.80094803575441,-0.226333640628825,"SERF1B///SERF1A","small EDRK-rich factor 1B///small EDRK-rich factor 1A",TRUE
+"233746_x_at",0.778007390824139,0.297288346784755,-1.06739000309463,-5.39949344998169,-0.406186905600523,"SERF2-C15ORF63///MIR1282///HYPK///SERF2","SERF2-C15orf63 readthrough///microRNA 1282///huntingtin interacting protein K///small EDRK-rich factor 2",TRUE
+"218680_x_at",0.95018792835023,0.773515557255518,-0.291321131649809,-5.89843173386256,-0.118751135643246,"SERF2-C15ORF63///MIR1282///HYPK///SERF2","SERF2-C15orf63 readthrough///microRNA 1282///huntingtin interacting protein K///small EDRK-rich factor 2",TRUE
+"223483_at",0.843725309945907,0.439080169854207,0.787940884919866,-5.64173127200973,0.453955935145171,"SERGEF","secretion regulating guanine nucleotide exchange factor",TRUE
+"232983_s_at",0.946391057046703,0.757613014853018,-0.312459609562666,-5.89224257206359,-0.123926568169166,"SERGEF","secretion regulating guanine nucleotide exchange factor",TRUE
+"220482_s_at",0.973936963444057,0.873888293796964,-0.160568422001651,-5.92713370931516,-0.131855458288343,"SERGEF","secretion regulating guanine nucleotide exchange factor",TRUE
+"217284_x_at",0.846018332779732,0.444045622619897,0.779303505979364,-5.64813472408796,0.62644803441755,"SERHL2","serine hydrolase-like 2",TRUE
+"217276_x_at",0.858246094096012,0.473977884064547,0.728432814002529,-5.6844935855721,0.879960468964196,"SERHL2","serine hydrolase-like 2",TRUE
+"214243_s_at",0.827768017240356,0.396573366554224,0.864505779393264,-5.58207897607264,0.903406533227146,"SERHL2///SERHL","serine hydrolase-like 2///serine hydrolase-like (pseudogene)",TRUE
+"208671_at",0.983777183253528,0.920657103530558,-0.100747378728303,-5.9347409821738,-0.0296400481487051,"SERINC1","serine incorporator 1",TRUE
+"222961_at",0.803203434524165,0.341216001626605,0.972672533788241,-5.48909251848212,0.67701945369298,"SERINC2","serine incorporator 2",TRUE
+"220490_at",0.842397669245069,0.436290348422727,0.792820074993452,-5.63808463378994,0.410753668789925,"SERINC2","serine incorporator 2",TRUE
+"224762_at",0.856900136251918,0.471541918599204,0.732499959098659,-5.68167221358664,0.63215588650079,"SERINC2","serine incorporator 2",TRUE
+"220489_s_at",0.931528703027792,0.697346836608702,0.39400074714175,-5.86435500909408,0.197065099897618,"SERINC2","serine incorporator 2",TRUE
+"221472_at",0.944705930911859,0.751341430265593,-0.320835687547651,-5.88967136236682,-0.164159134363597,"SERINC3","serine incorporator 3",TRUE
+"221473_x_at",0.98451040420843,0.92436495269199,0.0960237332417871,-5.93519348489462,0.051768762617094,"SERINC3","serine incorporator 3",TRUE
+"221471_at",0.989475734766121,0.948041089431436,-0.065909353521769,-5.93756787909922,-0.0291082111245586,"SERINC3","serine incorporator 3",TRUE
+"211769_x_at",0.996898592071515,0.984049039068131,-0.020219773631072,-5.93948435218817,-0.00975497701975314,"SERINC3","serine incorporator 3",TRUE
+"212812_at",0.769258076576208,0.27610948754591,1.11664526699368,-5.34995592475565,0.613336802801069,"SERINC5","serine incorporator 5",TRUE
+"235475_at",0.407748633394319,0.0156769392287378,2.6172877523412,-3.06123348447286,0.952469153367264,"SERP1","stress-associated endoplasmic reticulum protein 1",TRUE
+"200971_s_at",0.782489458032102,0.304903663270209,1.05029539787357,-5.416218842762,0.306469440959491,"SERP1","stress-associated endoplasmic reticulum protein 1",TRUE
+"200970_s_at",0.861962516141708,0.484329969184579,0.711283849872849,-5.69622550370225,0.244658224190138,"SERP1","stress-associated endoplasmic reticulum protein 1",TRUE
+"200969_at",0.993615552413264,0.970060138322906,-0.037959220906363,-5.93898169465944,-0.0141408416435169,"SERP1","stress-associated endoplasmic reticulum protein 1",TRUE
+"228044_at",0.593904766176258,0.0706469084239683,1.89911693679457,-4.32086442097296,1.30537204692927,"SERP2","stress-associated endoplasmic reticulum protein family member 2",TRUE
+"240668_s_at",0.617775129514679,0.0885674088281024,1.78136383674061,-4.50206260016595,1.31586871253815,"SERP2","stress-associated endoplasmic reticulum protein family member 2",TRUE
+"239890_s_at",0.739007386198624,0.225645849269749,1.24636928331948,-5.21012418727758,0.927978204922266,"SERP2","stress-associated endoplasmic reticulum protein family member 2",TRUE
+"1558727_at",0.837067957688307,0.419527652314614,0.822551800552487,-5.6154066980495,0.632372997418113,"SERP2","stress-associated endoplasmic reticulum protein family member 2",TRUE
+"239889_at",0.855557411779543,0.4688614149976,0.736989728243084,-5.6785403511062,0.603838794633607,"SERP2","stress-associated endoplasmic reticulum protein family member 2",TRUE
+"240667_at",0.925511384407886,0.678069956379661,-0.420639793072263,-5.85386911335946,-0.226390809618685,"SERP2","stress-associated endoplasmic reticulum protein family member 2",TRUE
+"230318_at",0.65284137151906,0.122213349070236,-1.6069980782519,-4.754531597396,-0.651461545257217,"SERPINA1","serpin family A member 1",TRUE
+"211429_s_at",0.871744769522775,0.514174166267597,-0.662992588976479,-5.72782865819479,-0.754985141205564,"SERPINA1","serpin family A member 1",TRUE
+"202833_s_at",0.936143408699214,0.714937945210322,-0.369942473815301,-5.87324421792359,-0.766399416102191,"SERPINA1","serpin family A member 1",TRUE
+"211428_at",0.971461462437557,0.864125409495896,-0.173124479107251,-5.92509571808673,-0.14172718788909,"SERPINA1","serpin family A member 1",TRUE
+"220626_at",0.896428361916712,0.580737643218713,0.560537064993065,-5.78779528986262,0.427772428722999,"SERPINA10","serpin family A member 10",TRUE
+"1552544_at",0.99753019043878,0.987617767553613,-0.0156955341029924,-5.93956349356114,-0.00723213662631839,"SERPINA12","serpin family A member 12",TRUE
+"208531_at",0.91202803207519,0.631337649085827,-0.486575332901959,-5.82502186223608,-0.280367576848251,"SERPINA2","serpin family A member 2 (gene/pseudogene)",TRUE
+"202376_at",0.932249295738588,0.700900839985733,-0.389121503238102,-5.86620244011416,-0.698726383573342,"SERPINA3","serpin family A member 3",TRUE
+"213874_at",0.917102138198416,0.649241814491779,-0.461070825795687,-5.83666762053428,-0.167433178167868,"SERPINA4","serpin family A member 4",TRUE
+"209443_at",0.932633693661011,0.702685417852627,0.386675109313382,-5.86712018057791,0.569555915972686,"SERPINA5","serpin family A member 5",TRUE
+"206325_at",0.855405088766616,0.468428231267005,-0.737716721261579,-5.67803152489452,-1.00315786729012,"SERPINA6","serpin family A member 6",TRUE
+"206386_at",0.839519981963042,0.427560237545683,0.808214037691899,-5.62644069363803,0.572274503631632,"SERPINA7","serpin family A member 7",TRUE
+"1553499_s_at",0.892824991541776,0.5662242163723,0.582329205333045,-5.77585293897249,0.233176746438198,"SERPINA9","serpin family A member 9",TRUE
+"212268_at",0.562414216355319,0.0550101013394375,2.0256524729663,-4.11722578614913,1.2136490312073,"SERPINB1","serpin family B member 1",TRUE
+"239213_at",0.569000095699173,0.0587850921973673,1.99243757561619,-4.17153990390079,1.14679291530322,"SERPINB1","serpin family B member 1",TRUE
+"213572_s_at",0.683861743647864,0.152876308091999,1.48028900699863,-4.92528953880132,0.92642091297974,"SERPINB1","serpin family B member 1",TRUE
+"228726_at",0.73759219552868,0.224281641035586,1.25016752510858,-5.20582961282069,0.853094428838697,"SERPINB1","serpin family B member 1",TRUE
+"214539_at",0.855439520086837,0.468594670811171,0.737437346134058,-5.67822711731604,0.522065104803865,"SERPINB10","serpin family B member 10",TRUE
+"1552463_at",0.659870891937597,0.127671758181378,1.58265102817057,-4.78819853527287,0.560120637715244,"SERPINB11","serpin family B member 11 (gene/pseudogene)",TRUE
+"1553057_at",0.7768734672127,0.29477338579782,-1.07310407489909,-5.39384886841371,-0.637861574284291,"SERPINB12","serpin family B member 12",TRUE
+"211362_s_at",0.515810181619652,0.0361174562076312,2.23098416363046,-3.76873696315821,0.831593486567932,"SERPINB13","serpin family B member 13",TRUE
+"217272_s_at",0.540483367247649,0.0447374698115614,2.12759825024489,-3.94686551212907,1.82137537243517,"SERPINB13","serpin family B member 13",TRUE
+"216257_at",0.546331365187588,0.0474136685471441,2.09916368072048,-3.99492473030512,1.22958529826657,"SERPINB13","serpin family B member 13",TRUE
+"211361_s_at",0.61591966964196,0.0869573893944875,1.79105237535869,-4.48746935758916,1.91049812979977,"SERPINB13","serpin family B member 13",TRUE
+"216258_s_at",0.878114621305798,0.530049949428143,0.637942006864894,-5.74338391553542,0.627156130276957,"SERPINB13","serpin family B member 13",TRUE
+"215817_at",0.954723352940649,0.794072270252977,-0.26419403716221,-5.90574427530087,-0.152793237275279,"SERPINB13","serpin family B member 13",TRUE
+"204614_at",0.103297663160259,0.000479883062509479,4.08885606791821,-0.00891899103979377,4.89095685593107,"SERPINB2","serpin family B member 2",TRUE
+"209719_x_at",0.62533487066658,0.0966223866006634,1.73505179711709,-4.57101546492944,0.874783929590914,"SERPINB3","serpin family B member 3",TRUE
+"209720_s_at",0.775289966640737,0.291677299594778,1.08018664289834,-5.38681504918357,1.46620360852398,"SERPINB3","serpin family B member 3",TRUE
+"211906_s_at",0.70478075908244,0.176688246268734,1.39552297125045,-5.03319585164299,1.75327974669539,"SERPINB4","serpin family B member 4",TRUE
+"210413_x_at",0.731548533938014,0.215133958348335,1.27610429356102,-5.17620451205642,0.69452658199691,"SERPINB4///SERPINB3","serpin family B member 4///serpin family B member 3",TRUE
+"204855_at",0.171054203824867,0.00145937747952336,3.63233403816653,-0.989771244473013,6.34767773691584,"SERPINB5","serpin family B member 5",TRUE
+"1555551_at",0.526065175064919,0.0394815722863084,2.18821838610809,-3.84305260966261,1.70455153735123,"SERPINB5","serpin family B member 5",TRUE
+"231628_s_at",0.199181589554674,0.00220402124701559,3.46129446216439,-1.35266539667049,3.11143791127087,"SERPINB6","serpin family B member 6",TRUE
+"211474_s_at",0.621053291599968,0.0910537391031613,1.76669576447507,-4.52404604011814,0.701432081351705,"SERPINB6","serpin family B member 6",TRUE
+"1556950_s_at",0.680972290639028,0.148936590875677,1.49532892344593,-4.90560551260787,0.800847094270622,"SERPINB6","serpin family B member 6",TRUE
+"231655_x_at",0.918373706340477,0.653302284552781,0.455330214753171,-5.83920422931781,0.503316681832886,"SERPINB6","serpin family B member 6",TRUE
+"206421_s_at",0.358427723880268,0.0101319155511012,2.81113978180373,-2.68516764906588,4.66703345416257,"SERPINB7","serpin family B member 7",TRUE
+"206034_at",0.112518135066489,0.000570515148135258,4.01815344216142,-0.161529951498588,2.11771213512668,"SERPINB8","serpin family B member 8",TRUE
+"1554616_at",0.833141091249911,0.41042429546503,0.839011044702557,-5.60251618052434,0.277726329198527,"SERPINB8","serpin family B member 8",TRUE
+"209723_at",0.399312926596283,0.0141319323218309,2.66379336648252,-2.97214982057221,2.7932741638756,"SERPINB9","serpin family B member 9",TRUE
+"209722_s_at",0.676468346171966,0.143272983070786,1.51752917143493,-4.87625872403396,1.83089265020862,"SERPINB9","serpin family B member 9",TRUE
+"242814_at",0.769258076576208,0.276272109071288,1.11625680560919,-5.35035437739543,0.798254148348613,"SERPINB9","serpin family B member 9",TRUE
+"239186_at",0.51470556386048,0.0352754943060027,2.24225357827439,-3.74900882104286,1.23367234470726,"SERPINB9P1","serpin family B member 9 pseudogene 1",TRUE
+"210049_at",0.87887877854929,0.532301499780699,-0.634422648028311,-5.74552315914323,-0.285923201350558,"SERPINC1","serpin family C member 1",TRUE
+"1554491_a_at",0.926789913499188,0.680934204209893,-0.416662480825733,-5.85547754229597,-0.295446334059722,"SERPINC1","serpin family C member 1",TRUE
+"205576_at",0.838303520227789,0.423143571488734,0.816076503140397,-5.62041245736538,0.543984569787189,"SERPIND1","serpin family D member 1",TRUE
+"202628_s_at",0.358427723880268,0.0101374609532251,2.81089957143486,-2.68564103086771,4.65824253351724,"SERPINE1","serpin family E member 1",TRUE
+"202627_s_at",0.425751189365875,0.0182217525156677,2.54933757266097,-3.19000815291426,3.74477354641253,"SERPINE1","serpin family E member 1",TRUE
+"1568765_at",0.627053909308516,0.097875703179566,1.72814567110194,-4.58118265245993,1.61021800922864,"SERPINE1","serpin family E member 1",TRUE
+"212190_at",0.627092759817312,0.0984827718532921,1.72482766057422,-4.5860566897146,1.96134447280069,"SERPINE2","serpin family E member 2",TRUE
+"227487_s_at",0.852292787786793,0.457938824450162,0.755444053640137,-5.66547695084864,0.598539300392161,"SERPINE2","serpin family E member 2",TRUE
+"202283_at",0.923708852928185,0.672315924186552,-0.428650856380142,-5.85058384267613,-0.46258849561756,"SERPINF1","serpin family F member 1",TRUE
+"205075_at",0.468735421183467,0.0248565801848437,2.40690196988003,-3.45421713979757,1.18061992575595,"SERPINF2","serpin family F member 2",TRUE
+"200986_at",0.664094349733756,0.132111395012623,1.56347841398724,-4.8144273093106,1.97278728990801,"SERPING1","serpin family G member 1",TRUE
+"207714_s_at",0.97345342693821,0.871896767739311,0.163127514325536,-5.92673075073945,0.150979282032198,"SERPINH1","serpin family H member 1",TRUE
+"205352_at",0.967777603239069,0.848511293396822,0.19326608075545,-5.92150716472384,0.218840304422139,"SERPINI1","serpin family I member 1",TRUE
+"207636_at",0.990810941805126,0.955926112677243,0.0558954113746682,-5.93816186543179,0.0270028949665004,"SERPINI2","serpin family I member 2",TRUE
+"223394_at",0.613028549026003,0.0846298946145089,-1.80533564092977,-4.46585048836599,-0.633562599571761,"SERTAD1","SERTA domain containing 1",TRUE
+"202656_s_at",0.841550580403629,0.432913240740848,0.79875217535406,-5.63362253980761,0.467895555961343,"SERTAD2","SERTA domain containing 2",TRUE
+"202657_s_at",0.968066640321622,0.849526660167217,0.19195389931389,-5.92175292516753,0.104339868644038,"SERTAD2","SERTA domain containing 2",TRUE
+"219382_at",0.597654932724127,0.0747709382194497,-1.86988943631524,-4.36660831839187,-0.722357842906234,"SERTAD3","SERTA domain containing 3",TRUE
+"230660_at",0.896159990898752,0.579327020667965,-0.562642977331582,-5.78666049623695,-0.55639709265032,"SERTAD4","SERTA domain containing 4",TRUE
+"229674_at",0.971826767527606,0.865145106061381,0.171811748571788,-5.92531594854917,0.132682012757078,"SERTAD4","SERTA domain containing 4",TRUE
+"235337_at",0.980019293742949,0.906137747385645,-0.119268103045655,-5.93275744010041,-0.111886676467474,"SERTAD4","SERTA domain containing 4",TRUE
+"233907_s_at",0.993846586666397,0.970857945000162,-0.036947234832366,-5.93901861363767,-0.0301413761870295,"SERTAD4","SERTA domain containing 4",TRUE
+"230121_at",0.990391782914487,0.951803175160443,0.0611307254238046,-5.93786350649127,0.0407421433344943,"SERTAD4-AS1","SERTAD4 antisense RNA 1",TRUE
+"241672_at",0.957813759927439,0.810356458687253,-0.24284894063125,-5.91099939012603,-0.0851049319271802,"SERTM1","serine rich and transmembrane domain containing 1",TRUE
+"218346_s_at",0.854184492233394,0.464524555052848,-0.744286137024376,-5.67341198317516,-0.310625699652155,"SESN1","sestrin 1",TRUE
+"223196_s_at",0.482247562654866,0.0274309999059284,-2.36101827486683,-3.53756604784322,-0.953236160232473,"SESN2","sestrin 2",TRUE
+"223195_s_at",0.897685929386823,0.58484628240856,-0.554417818396077,-5.79106928007456,-0.266530766717185,"SESN2","sestrin 2",TRUE
+"235683_at",0.778686132916778,0.299348706241284,1.06273448674521,-5.40407240102749,1.40125008068061,"SESN3","sestrin 3",TRUE
+"242906_at",0.864372319761811,0.491684380739133,0.699229601417713,-5.70431271169927,0.803055770581193,"SESN3","sestrin 3",TRUE
+"242899_at",0.873301865850313,0.51821318576508,0.656579441954698,-5.73186567109311,0.509189187460327,"SESN3","sestrin 3",TRUE
+"235684_s_at",0.945272089973488,0.752869836524621,-0.318792273338484,-5.89030484207708,-0.270810533671929,"SESN3","sestrin 3",TRUE
+"235150_at",0.953564723226096,0.786251568488677,0.274489433965289,-5.90305246021705,0.290945574529835,"SESN3","sestrin 3",TRUE
+"225123_at",0.962966981693287,0.832013767618477,-0.214636687136448,-5.91726989192731,-0.23576740863651,"SESN3","sestrin 3",TRUE
+"1553869_at",0.968035667633768,0.848996713848987,-0.192638717753888,-5.92162487262508,-0.176615411088028,"SESN3","sestrin 3",TRUE
+"226763_at",0.212348514754308,0.00251894834334961,3.40557232442029,-1.47006655419253,1.46927773601826,"SESTD1","SEC14 and spectrin domain containing 1",TRUE
+"228088_at",0.360736459722853,0.0103457085443036,2.80196813765659,-2.70322988562272,1.48847414090752,"SESTD1","SEC14 and spectrin domain containing 1",TRUE
+"227041_at",0.487765518929235,0.0289135445239991,2.33636678213812,-3.58197255098837,1.14782734060489,"SESTD1","SEC14 and spectrin domain containing 1",TRUE
+"213048_s_at",0.929024902913511,0.6871181568571,0.408098560335219,-5.85888977527879,0.145022107050849,"SET","SET nuclear proto-oncogene",TRUE
+"210231_x_at",0.982143525809546,0.914098538598452,0.109108541606753,-5.93388681596164,0.0327495562890565,"SET","SET nuclear proto-oncogene",TRUE
+"205933_at",0.76145107371764,0.260526546012937,-1.15467254611452,-5.31035855797764,-1.03043441423275,"SETBP1","SET binding protein 1",TRUE
+"227478_at",0.910327933615304,0.627292525727206,-0.492382618499566,-5.82228449922717,-0.422467833778424,"SETBP1","SET binding protein 1",TRUE
+"213202_at",0.854040699678541,0.463217812789809,-0.746492550016447,-5.67185174868796,-0.404671243882502,"SETD1A","SET domain containing 1A",TRUE
+"213153_at",0.751579819725748,0.244890617072048,-1.19455952500578,-5.26757603842982,-0.488693126845568,"SETD1B","SET domain containing 1B",TRUE
+"220946_s_at",0.82064687791745,0.381366604536223,0.893167055323729,-5.5584248688301,0.323499152560659,"SETD2","SET domain containing 2",TRUE
+"215038_s_at",0.947778780715578,0.76151305264558,-0.307262392882927,-5.89380409050906,-0.0942553317114623,"SETD2","SET domain containing 2",TRUE
+"212493_s_at",0.960198517898473,0.81976462459443,0.230569848062106,-5.91382313037934,0.0804797600047173,"SETD2","SET domain containing 2",TRUE
+"212465_at",0.715374460600121,0.191119794165267,-1.34850495624197,-5.09078167231427,-0.497658373210923,"SETD3","SET domain containing 3",TRUE
+"229940_at",0.841247691968787,0.431299571295881,0.801596787515578,-5.63147174488888,0.215896876693432,"SETD3","SET domain containing 3",TRUE
+"219482_at",0.822173415758858,0.386660572412582,-0.883106068701156,-5.5668096904621,-0.372230356932541,"SETD4","SET domain containing 4",TRUE
+"213989_x_at",0.870980161749509,0.511216435701565,-0.667706640685137,-5.72483722935948,-0.253698730416728,"SETD4","SET domain containing 4",TRUE
+"230899_at",0.891263729611392,0.56057921166175,-0.590882187491735,-5.77104534524008,-0.327630515704083,"SETD4","SET domain containing 4",TRUE
+"1569105_at",0.833057833553471,0.410154550519534,0.839502263128088,-5.60212780068547,0.265669647649434,"SETD5","SET domain containing 5",TRUE
+"244691_at",0.841420204214686,0.432441422003414,-0.799583227841939,-5.63299492891577,-0.302729018230553,"SETD5","SET domain containing 5",TRUE
+"1569106_s_at",0.907964244160782,0.618170904672814,-0.505541512969922,-5.81596449759786,-0.162673973643482,"SETD5","SET domain containing 5",TRUE
+"221806_s_at",0.946941640414848,0.759177608878682,-0.31037357414153,-5.89287244474226,-0.0928233744181011,"SETD5","SET domain containing 5",TRUE
+"222575_at",0.985736911886368,0.931212877569824,-0.0873055605619203,-5.93597164029848,-0.0289521907343726,"SETD5","SET domain containing 5",TRUE
+"219751_at",0.895657764833717,0.575212702649193,0.568799986188395,-5.78331905906705,0.30331837197453,"SETD6","SET domain containing 6",TRUE
+"1554555_a_at",0.971242929121865,0.863176415089909,0.174346469302525,-5.92488920858297,0.0747746693761506,"SETD6","SET domain containing 6",TRUE
+"244653_at",0.477709967865451,0.0265681535428869,-2.37593667483744,-3.5105646974429,-1.68737914317464,"SETD7","SET domain containing lysine methyltransferase 7",TRUE
+"224928_at",0.56861088242915,0.0583266340483422,-1.99636855582966,-4.16514317536413,-0.631509487618498,"SETD7","SET domain containing lysine methyltransferase 7",TRUE
+"240840_s_at",0.454713655038042,0.0220590924475183,2.46204001005076,-3.35289667493019,1.37687744607423,"SETD9","SET domain containing 9",TRUE
+"238465_at",0.896118635245982,0.578387914981574,0.564046390569081,-5.7859019601857,0.315860949216157,"SETD9","SET domain containing 9",TRUE
+"203155_at",0.80110325033185,0.337655287418712,-0.980022919529108,-5.48240956951756,-0.423829666099536,"SETDB1","SET domain bifurcated 1",TRUE
+"214197_s_at",0.978605239070903,0.896540218108121,-0.131533689635433,-5.93126025889936,-0.0370007262334298,"SETDB1","SET domain bifurcated 1",TRUE
+"238684_at",0.758081075834994,0.254905017841608,-1.16880251872664,-5.29534822185798,-0.450457144194308,"SETDB2","SET domain bifurcated 2",TRUE
+"1564972_x_at",0.774011928861764,0.285666822947362,-1.09409194842788,-5.37288540656918,-0.998037875343536,"SETDB2","SET domain bifurcated 2",TRUE
+"235339_at",0.839519981963042,0.427880858385896,0.807645249936446,-5.62687466490143,0.300211196489165,"SETDB2","SET domain bifurcated 2",TRUE
+"235338_s_at",0.866602763987519,0.497778756189278,-0.689318812782603,-5.71086308292787,-0.322504239532697,"SETDB2","SET domain bifurcated 2",TRUE
+"1564970_at",0.94895689004559,0.768033032708513,-0.298592994951632,-5.89635107103607,-0.311517801756028,"SETDB2","SET domain bifurcated 2",TRUE
+"238731_at",0.998347572104896,0.99301989226416,0.00884762196666085,-5.9396453533173,0.00577751013907246,"SETDB2","SET domain bifurcated 2",TRUE
+"1554059_at",0.661974206478491,0.129608196103661,1.57422156553064,-4.79976118801023,0.557525948034046,"SETMAR","SET domain and mariner transposase fusion gene",TRUE
+"206554_x_at",0.870517518639056,0.509636858785872,-0.670230415839627,-5.72322735625753,-0.311020372053355,"SETMAR","SET domain and mariner transposase fusion gene",TRUE
+"1554060_s_at",0.872668627020452,0.516411784119716,-0.659436268759219,-5.73007197379737,-0.296431970425176,"SETMAR","SET domain and mariner transposase fusion gene",TRUE
+"40189_at",0.809744885587232,0.353183933740566,-0.948344196270667,-5.51088376923342,-0.24172811824443,"SETSIP///SET","SET-like protein///SET nuclear proto-oncogene",TRUE
+"200631_s_at",0.82064687791745,0.381352579543931,-0.893193830370528,-5.55840243716654,-0.226050248621345,"SETSIP///SET","SET-like protein///SET nuclear proto-oncogene",TRUE
+"213047_x_at",0.873301865850313,0.518105225327334,-0.656750500555054,-5.73175847986206,-0.155946627061439,"SETSIP///SET","SET-like protein///SET nuclear proto-oncogene",TRUE
+"200630_x_at",0.958101903460289,0.810906524812822,0.242129987585472,-5.91116873783375,0.0673678430725388,"SETSIP///SET","SET-like protein///SET nuclear proto-oncogene",TRUE
+"215780_s_at",0.980644417128518,0.909421024711191,0.115076489031883,-5.93323555697965,0.0620753222203252,"SETSIP///SETP4///SET","SET-like protein///SET pseudogene 4///SET nuclear proto-oncogene",TRUE
+"201964_at",0.741069393895066,0.231300397015442,-1.23080994829126,-5.22759929708843,-0.331890457948985,"SETX","senataxin",TRUE
+"232229_at",0.812302873476553,0.356872729582246,0.940958496473114,-5.5173992025104,0.355827354819752,"SETX","senataxin",TRUE
+"201965_s_at",0.831182446031643,0.405160034254203,0.84863490500472,-5.59486847332091,0.222290668234518,"SETX","senataxin",TRUE
+"229651_at",0.554383599468784,0.0507792055992624,2.06538397425143,-4.05147706624152,1.53269052659809,"SEZ6","seizure related 6 homolog",TRUE
+"243430_at",0.661974206478491,0.129487237965468,1.57474503332965,-4.79904455801404,0.668721059002915,"SEZ6","seizure related 6 homolog",TRUE
+"213609_s_at",0.687545925823023,0.156414826648959,1.46704697098141,-4.94248755270943,1.06872234451446,"SEZ6L","seizure related 6 homolog like",TRUE
+"207873_x_at",0.732963666545614,0.217331892808468,-1.26979626365113,-5.18345745156972,-0.959947615382946,"SEZ6L","seizure related 6 homolog like",TRUE
+"216047_x_at",0.812896635201594,0.361747959923527,-0.931275733266889,-5.5258701748928,-0.606322741443695,"SEZ6L","seizure related 6 homolog like",TRUE
+"211894_x_at",0.897949253801113,0.586729163645523,-0.551620677365938,-5.79255422101088,-0.345102917783213,"SEZ6L","seizure related 6 homolog like",TRUE
+"231650_s_at",0.953564723226096,0.786004000952512,0.274815828380469,-5.90296545100728,0.216549787603586,"SEZ6L","seizure related 6 homolog like",TRUE
+"240709_at",0.96882227301574,0.852881419331828,0.187620905697324,-5.92255260691477,0.173483734679436,"SEZ6L","seizure related 6 homolog like",TRUE
+"233337_s_at",0.468735421183467,0.0250525437124604,-2.40325845926606,-3.46086820553942,-1.79568697749701,"SEZ6L2","seizure related 6 homolog like 2",TRUE
+"218720_x_at",0.590910793348582,0.0684394924362864,-1.91538061336371,-4.29519566916482,-1.27583488323688,"SEZ6L2","seizure related 6 homolog like 2",TRUE
+"223458_at",0.653375957820821,0.122736744971734,-1.60462462814141,-4.75783116528484,-0.803188156596741,"SEZ6L2","seizure related 6 homolog like 2",TRUE
+"238406_x_at",0.935094665155941,0.711576339972182,-0.374522340404788,-5.8715945737134,-0.14472827260848,"SEZ6L2","seizure related 6 homolog like 2",TRUE
+"238404_x_at",0.986421906591669,0.93630001927316,0.0808335849484108,-5.93650147795587,0.0416507520557454,"SEZ6L2","seizure related 6 homolog like 2",TRUE
+"1555749_at",0.909052380289506,0.622305751148104,-0.499565492439752,-5.81885485031457,-0.384861864675268,"SF1","splicing factor 1",TRUE
+"210172_at",0.986889306520757,0.939560358153296,-0.0766875859961453,-5.93681947527063,-0.0495326543325891,"SF1","splicing factor 1",TRUE
+"208313_s_at",0.993225426079816,0.968015888068098,-0.0405524591459577,-5.93888253622713,-0.0114904384358692,"SF1","splicing factor 1",TRUE
+"201356_at",0.920119557710459,0.659871747945826,0.446075135324115,-5.84322816675868,0.107324310690567,"SF3A1","splicing factor 3a subunit 1",TRUE
+"227516_at",0.939356991756184,0.728457518198295,0.351603319355834,-5.87964907874289,0.123347977166736,"SF3A1","splicing factor 3a subunit 1",TRUE
+"216457_s_at",0.942502815705589,0.741881858437314,-0.33351417417809,-5.88565136071101,-0.0735897332154387,"SF3A1","splicing factor 3a subunit 1",TRUE
+"201357_s_at",0.995375928428862,0.978582524735916,0.027150794778176,-5.93932444091485,0.0091032417247181,"SF3A1","splicing factor 3a subunit 1",TRUE
+"37462_i_at",0.83872852514497,0.424045915076584,0.814466017438754,-5.62165169190494,0.259917770315049,"SF3A2","splicing factor 3a subunit 2",TRUE
+"209381_x_at",0.896428361916712,0.58077810692029,0.560476694731676,-5.78782776016617,0.266808544071015,"SF3A2","splicing factor 3a subunit 2",TRUE
+"203818_s_at",0.965968336088978,0.840511707747545,0.2036164766918,-5.91951015556208,0.0719933528887609,"SF3A3","splicing factor 3a subunit 3",TRUE
+"229303_at",0.624520459874487,0.0960328457688895,-1.73832683919321,-4.56618342815429,-0.713343987889029,"SF3B1","splicing factor 3b subunit 1",TRUE
+"211185_s_at",0.863918945062466,0.490236382827785,-0.701594688889878,-5.702736362493,-0.159485559155657,"SF3B1","splicing factor 3b subunit 1",TRUE
+"201070_x_at",0.948429371744093,0.76577537133546,0.301592253813943,-5.89547809369312,0.0945214837611719,"SF3B1","splicing factor 3b subunit 1",TRUE
+"201071_x_at",0.969882914559333,0.856298726238071,-0.18321090103107,-5.92334781733357,-0.0415198405507997,"SF3B1","splicing factor 3b subunit 1",TRUE
+"214305_s_at",0.989669132517581,0.95043481826618,-0.0628686473182509,-5.93775856323754,-0.016554076362306,"SF3B1","splicing factor 3b subunit 1",TRUE
+"200619_at",0.83633038614858,0.41785500718391,-0.825558989086288,-5.6130693765675,-0.269682124561548,"SF3B2","splicing factor 3b subunit 2",TRUE
+"1558230_at",0.936456142259101,0.716481289902149,0.367842516418821,-5.8739939139042,0.101438115407685,"SF3B2","splicing factor 3b subunit 2",TRUE
+"200688_at",0.662471354228862,0.130163155089149,-1.57182506470604,-4.80303962440745,-0.749726485382608,"SF3B3","splicing factor 3b subunit 3",TRUE
+"200687_s_at",0.699127697175283,0.17047591145388,-1.41670722623241,-5.00671689412491,-0.506687344330803,"SF3B3","splicing factor 3b subunit 3",TRUE
+"209044_x_at",0.890405697398587,0.558946056480023,-0.593364938931616,-5.76963710849297,-0.166544996223893,"SF3B4","splicing factor 3b subunit 4",TRUE
+"221263_s_at",0.955904644595647,0.800574494132149,-0.255656527315471,-5.90789895344776,-0.0936345108393866,"SF3B5","splicing factor 3b subunit 5",TRUE
+"223416_at",0.868832441105076,0.505217920439939,-0.677314160505768,-5.71867769948864,-0.197716876162596,"SF3B6","splicing factor 3b subunit 6",TRUE
+"1561923_a_at",0.996625121774816,0.983219252900942,0.0212717897561749,-5.93946309242428,0.0209642496363145,"SF3B6","splicing factor 3b subunit 6",TRUE
+"215699_x_at",0.697172073261335,0.167429301987467,-1.42732275474291,-4.99332487354659,-0.572505199106283,"SFI1","SFI1 centrin binding protein",TRUE
+"36545_s_at",0.897949253801113,0.58592648040312,-0.552812569539738,-5.7919223631728,-0.249025711330509,"SFI1","SFI1 centrin binding protein",TRUE
+"213431_x_at",0.919354071504066,0.656592415168117,-0.450690071431916,-5.84123180609486,-0.201071054176509,"SFI1","SFI1 centrin binding protein",TRUE
+"214402_s_at",0.95442332217412,0.790473640580058,-0.268927685089183,-5.90451931405457,-0.0811722615184944,"SFI1","SFI1 centrin binding protein",TRUE
+"239054_at",0.819018525257656,0.375019873564837,0.905350331206817,-5.54815370883386,0.305619235353346,"SFMBT1","Scm-like with four mbt domains 1",TRUE
+"213370_s_at",0.925091998149497,0.675955304744792,0.423580641348804,-5.85267017180916,0.163715605308154,"SFMBT1","Scm-like with four mbt domains 1",TRUE
+"227210_at",0.194325783329824,0.00204283859641937,-3.49290554703782,-1.28587019594726,-4.63768407462481,"SFMBT2","Scm-like with four mbt domains 2",TRUE
+"232938_at",0.991689960875868,0.960778881987354,-0.0497353945911361,-5.93847874859079,-0.0267308636682806,"SFMBT2","Scm-like with four mbt domains 2",TRUE
+"33322_i_at",0.604395008363632,0.0786182330959257,1.84386532136148,-4.4069162210009,1.17224753391469,"SFN","stratifin",TRUE
+"33323_r_at",0.623667408398064,0.0952215156465529,1.74286220285153,-4.55948074377532,1.49751874323368,"SFN","stratifin",TRUE
+"209260_at",0.640126343064811,0.11084986220645,1.66075417983987,-4.67879528033869,1.8429888273414,"SFN","stratifin",TRUE
+"226898_s_at",0.852503125709186,0.458493312912707,0.75450092351019,-5.66615198958313,0.184940473029049,"SFPQ","splicing factor proline and glutamine rich",TRUE
+"214016_s_at",0.909253608893833,0.62331476021856,0.498109992125382,-5.81955373465212,0.178328335026837,"SFPQ","splicing factor proline and glutamine rich",TRUE
+"201586_s_at",0.937517914799988,0.723091837475215,-0.358866751948445,-5.87715081546723,-0.0821830017777252,"SFPQ","splicing factor proline and glutamine rich",TRUE
+"201585_s_at",0.966194888753897,0.84246460494197,0.201087632267455,-5.92000765039939,0.0626393022235447,"SFPQ","splicing factor proline and glutamine rich",TRUE
+"221768_at",0.992342196993659,0.964166570318213,-0.045436308081525,-5.93867800935193,-0.0175368883158011,"SFPQ","splicing factor proline and glutamine rich",TRUE
+"236027_at",0.399312926596283,0.0141578320254094,2.66297509395267,-2.9737237199896,1.20331769181272,"SFR1","SWI5 dependent homologous recombination repair protein 1",TRUE
+"238794_at",0.516545992966588,0.0363977317232927,2.22728580675251,-3.77519821977265,0.957295385901269,"SFR1","SWI5 dependent homologous recombination repair protein 1",TRUE
+"202036_s_at",0.541849190341655,0.0453068013368479,2.12142330231249,-3.9573371936978,4.0063116282644,"SFRP1","secreted frizzled related protein 1",TRUE
+"202035_s_at",0.604824625238112,0.0788476879170326,1.84234852212403,-4.40925314379723,2.95124778835165,"SFRP1","secreted frizzled related protein 1",TRUE
+"202037_s_at",0.637485146909712,0.10899582729375,1.66996096375248,-4.66563292178012,2.29853437974552,"SFRP1","secreted frizzled related protein 1",TRUE
+"228413_s_at",0.96200396340887,0.827483543398973,-0.22052256535922,-5.91602522085651,-0.208031274586239,"SFRP1","secreted frizzled related protein 1",TRUE
+"223122_s_at",0.547024587451534,0.0474932972398065,2.09833994687043,-3.99631081674162,1.43477573458095,"SFRP2","secreted frizzled related protein 2",TRUE
+"223121_s_at",0.768852835478002,0.273278075266657,1.12343569581434,-5.3429710232392,0.397567631773436,"SFRP2","secreted frizzled related protein 2",TRUE
+"204052_s_at",0.952644489493803,0.783091075673505,-0.278658546993769,-5.90193335335593,-0.164566170984862,"SFRP4","secreted frizzled related protein 4",TRUE
+"204051_s_at",0.984798640722849,0.925290491748113,0.0948449883131772,-5.93530301896807,0.0594101180392235,"SFRP4","secreted frizzled related protein 4",TRUE
+"207468_s_at",0.990810941805126,0.956553386524222,0.0550990418347182,-5.93820491181843,0.0323270847730068,"SFRP5","secreted frizzled related protein 5",TRUE
+"240078_at",0.702185342714694,0.173674483576238,-1.40572440878625,-5.02048575102561,-1.24463798668771,"SFSWAP","splicing factor SWAP homolog",TRUE
+"202774_s_at",0.796963640275795,0.329860354765048,-0.996302110869679,-5.46744559632154,-0.264555013145243,"SFSWAP","splicing factor SWAP homolog",TRUE
+"202775_s_at",0.79943091106207,0.334058067258542,-0.987502918761168,-5.47556173693161,-0.246261300731801,"SFSWAP","splicing factor SWAP homolog",TRUE
+"202773_s_at",0.871744769522775,0.513488681336625,-0.664083772533155,-5.72713802456464,-0.195877994789109,"SFSWAP","splicing factor SWAP homolog",TRUE
+"232487_at",0.679482812809504,0.146795628439065,-1.50363859426957,-4.89466140404574,-0.734496844720521,"SFT2D1","SFT2 domain containing 1",TRUE
+"226836_at",0.837368340567858,0.42113086767123,0.819676501072461,-5.61763403785674,0.527074331461947,"SFT2D1","SFT2 domain containing 1",TRUE
+"225850_at",0.88587213211399,0.547830526136135,0.610364468573001,-5.7598416537331,0.191214991103795,"SFT2D1","SFT2 domain containing 1",TRUE
+"1560694_at",0.913140067375992,0.635398516018649,-0.480762463469783,-5.82773006435159,-0.315649527584806,"SFT2D1","SFT2 domain containing 1",TRUE
+"225849_s_at",0.99872918752906,0.994536463468172,0.00692525851430814,-5.93966012161534,0.0022275100129292,"SFT2D1","SFT2 domain containing 1",TRUE
+"214838_at",0.900736310608905,0.596176208684845,0.537652826235356,-5.79986023219057,0.199366633303953,"SFT2D2","SFT2 domain containing 2",TRUE
+"225356_at",0.973071267819624,0.870336673183524,0.165132999599656,-5.9264105223868,0.068221604932198,"SFT2D2","SFT2 domain containing 2",TRUE
+"226639_at",0.594972224548427,0.0715479368102236,-1.8926061605842,-4.33109748471203,-0.944051517133774,"SFT2D3","SFT2 domain containing 3",TRUE
+"229023_at",0.946727564264032,0.75862129387222,-0.311115134006056,-5.89264901162398,-0.210596286816512,"SFT2D3","SFT2 domain containing 3",TRUE
+"229472_at",0.697172073261335,0.166853362496169,-1.42934693255785,-4.9907619704193,-0.445908531871718,"SFT2D3///WDR33","SFT2 domain containing 3///WD repeat domain 33",TRUE
+"229141_at",0.783844746433788,0.306710638843163,-1.04628378851996,-5.42010868136847,-0.370673953757237,"SFT2D3///WDR33","SFT2 domain containing 3///WD repeat domain 33",TRUE
+"223146_at",0.80392795268584,0.342510980483309,-0.970012335074256,-5.49149985245324,-0.555556891922484,"SFT2D3///WDR33","SFT2 domain containing 3///WD repeat domain 33",TRUE
+"218851_s_at",0.888232641270866,0.553881822178501,-0.601087758427666,-5.76522018884845,-0.262424241006494,"SFT2D3///WDR33","SFT2 domain containing 3///WD repeat domain 33",TRUE
+"223147_s_at",0.925819519240262,0.678840592771894,0.41956900668088,-5.85430361831849,0.119404889045891,"SFT2D3///WDR33","SFT2 domain containing 3///WD repeat domain 33",TRUE
+"222763_s_at",0.984980551359303,0.925943465733116,0.0940134588147299,-5.93537947516802,0.0289278614594526,"SFT2D3///WDR33","SFT2 domain containing 3///WD repeat domain 33",TRUE
+"243818_at",0.299420079118957,0.00553112537558567,3.07329266722007,-2.15906641072364,3.28369317191265,"SFTA1P","surfactant associated 1, pseudogene",TRUE
+"244056_at",0.774230543658252,0.290250683869686,-1.08346832589765,-5.383541947781,-1.04212478037491,"SFTA2","surfactant associated 2",TRUE
+"228979_at",0.819479221404744,0.37659411309528,-0.902315810229589,-5.55072400346651,-0.957143088909705,"SFTA3","surfactant associated 3",TRUE
+"218835_at",0.580630437263151,0.0632776637698516,-1.95529012979886,-4.23156725280059,-1.24273716511627,"SFTPA2///SFTPA1","surfactant protein A2///surfactant protein A1",TRUE
+"223678_s_at",0.739340500562926,0.226867921347062,-1.24298162792231,-5.21394504484774,-0.940588330098885,"SFTPA2///SFTPA1","surfactant protein A2///surfactant protein A1",TRUE
+"37004_at",0.659543761956192,0.12738606921275,1.58390363036775,-4.78647622595838,0.928843466625651,"SFTPB","surfactant protein B",TRUE
+"214354_x_at",0.827809523023999,0.396812583727326,0.864060653888642,-5.58244068563085,0.596699868158764,"SFTPB","surfactant protein B",TRUE
+"209810_at",0.87045636854107,0.50912192788108,0.671054093974253,-5.72270068730353,0.290376608261986,"SFTPB","surfactant protein B",TRUE
+"213936_x_at",0.957524414951038,0.808348396465197,-0.245474652773458,-5.91037666882862,-0.0757291935554694,"SFTPB","surfactant protein B",TRUE
+"38691_s_at",0.55679801038721,0.052069666536562,2.05296163588308,-4.07212389351075,1.19762407317739,"SFTPC","surfactant protein C",TRUE
+"205982_x_at",0.637485146909712,0.108323422878749,1.67333270454693,-4.66079872739543,0.464712264786875,"SFTPC","surfactant protein C",TRUE
+"211735_x_at",0.904248700835242,0.606652886974623,0.522288022948878,-5.80768638162435,0.164555194208437,"SFTPC","surfactant protein C",TRUE
+"214387_x_at",0.957571530817866,0.808768268762404,0.24492548878379,-5.91050746076295,0.0894002915410343,"SFTPC","surfactant protein C",TRUE
+"215454_x_at",0.958861185763913,0.813843844290081,-0.238293019638631,-5.91206408359107,-0.121590588947961,"SFTPC","surfactant protein C",TRUE
+"214199_at",0.997466539876354,0.987127074158294,-0.0163175863686486,-5.93955379438658,-0.0166287256919482,"SFTPD","surfactant protein D",TRUE
+"218392_x_at",0.538265635881385,0.0438193021546967,-2.13770747192256,-3.92968040395052,-0.66119545609078,"SFXN1","sideroflexin 1",TRUE
+"230069_at",0.740476003158683,0.229428633354676,-1.23592802372764,-5.2218719188472,-0.532543472116455,"SFXN1","sideroflexin 1",TRUE
+"232055_at",0.888232641270866,0.55404427414823,-0.600839452854432,-5.76536306089469,-0.270749941665993,"SFXN1","sideroflexin 1",TRUE
+"237334_at",0.73223722457785,0.216087571839353,-1.2733613799702,-5.17936207019306,-0.815796419533149,"SFXN2","sideroflexin 2",TRUE
+"227560_at",0.801086839730802,0.336984572662835,-0.981413421588058,-5.48114017231612,-0.655495909096954,"SFXN2","sideroflexin 2",TRUE
+"217226_s_at",0.760439386481756,0.259248775774926,1.15786429374425,-5.30698195304813,0.601223060961363,"SFXN3","sideroflexin 3",TRUE
+"1559993_at",0.793993897335353,0.325773481461801,1.00494373849307,-5.4594111725019,0.711559087479949,"SFXN3","sideroflexin 3",TRUE
+"220974_x_at",0.849935057946582,0.451703885999149,0.76609666446104,-5.65779705283399,0.519479294861577,"SFXN3","sideroflexin 3",TRUE
+"230637_at",0.77673212102109,0.294185071094737,1.07444577740803,-5.3925195755496,0.702611359181585,"SFXN4","sideroflexin 4",TRUE
+"231505_s_at",0.834457927981261,0.412962068797316,0.834399635579589,-5.60615181528464,0.585369388507119,"SFXN4","sideroflexin 4",TRUE
+"229236_s_at",0.846836685339183,0.445357879291136,-0.777030713613104,-5.64980863477218,-0.267770131725877,"SFXN4","sideroflexin 4",TRUE
+"225143_at",0.979588787486838,0.902035381496873,0.124508497643803,-5.93213566943772,0.0461497311468939,"SFXN4","sideroflexin 4",TRUE
+"1563708_at",0.810375880424165,0.3543410908097,-0.946021758535388,-5.51293758605927,-0.477319627881812,"SFXN5","sideroflexin 5",TRUE
+"232691_at",0.949354801365424,0.771204270738826,0.294384777540561,-5.89756134886206,0.223280978470322,"SFXN5","sideroflexin 5",TRUE
+"241999_at",0.97928472590149,0.899325144986511,0.127972525809147,-5.93171001039271,0.0990676743436705,"SFXN5","sideroflexin 5",TRUE
+"226373_at",0.999503346640971,0.998771660072364,0.00155695931046451,-5.93968230004858,0.00062526295552523,"SFXN5","sideroflexin 5",TRUE
+"210632_s_at",0.828068961116677,0.397775169134101,0.862271261173677,-5.5838929996939,0.382381548192921,"SGCA","sarcoglycan alpha",TRUE
+"205120_s_at",0.84204847460846,0.435260043789747,0.794626856375209,-5.63672889605458,0.959569337165016,"SGCB","sarcoglycan beta",TRUE
+"226112_at",0.861659105448003,0.483473296582601,0.712694838111246,-5.6952702620125,0.978103169378091,"SGCB","sarcoglycan beta",TRUE
+"228584_at",0.863769633081355,0.489545696272773,0.702724236002629,-5.70198171970062,0.682998490373871,"SGCB","sarcoglycan beta",TRUE
+"205121_at",0.900654605906668,0.595725160823205,0.538317243378601,-5.79951682870852,0.551451113040256,"SGCB","sarcoglycan beta",TRUE
+"213543_at",0.713633547141264,0.188384727242543,-1.35719497212778,-5.08026239813047,-0.940265235266859,"SGCD","sarcoglycan delta",TRUE
+"230730_at",0.736020435324742,0.221171181834353,1.25889418407502,-5.19592013166822,0.861291483010476,"SGCD","sarcoglycan delta",TRUE
+"214492_at",0.844245372791972,0.441013373513927,0.784571013589821,-5.6442374891138,0.556656695867529,"SGCD","sarcoglycan delta",TRUE
+"228602_at",0.849935057946582,0.45174345832143,0.766028775128835,-5.65784631881835,0.312939839599895,"SGCD","sarcoglycan delta",TRUE
+"210330_at",0.956938436670832,0.804670081704245,-0.250288955514018,-5.90921760157011,-0.210198634390996,"SGCD","sarcoglycan delta",TRUE
+"210329_s_at",0.973071267819624,0.869941503707133,-0.165641095569884,-5.92632877191646,-0.103431439473701,"SGCD","sarcoglycan delta",TRUE
+"204688_at",0.929088650061781,0.687992906722475,0.406889670008836,-5.85936583319134,0.403221857400148,"SGCE","sarcoglycan epsilon",TRUE
+"207302_at",0.770075820151416,0.278789230696378,-1.11026517127763,-5.35648455065748,-1.47159062638171,"SGCG","sarcoglycan gamma",TRUE
+"1552971_at",0.586160254590095,0.0659758611202093,1.9340853032433,-4.26548690729184,1.30175087359138,"SGCZ","sarcoglycan zeta",TRUE
+"221822_at",0.280199223932988,0.00469254145811325,-3.14342428591987,-2.01545315942133,-1.55466171153754,"SGF29","SAGA complex associated factor 29",TRUE
+"48117_at",0.812302873476553,0.360842745980833,-0.933066939966894,-5.52430920522812,-0.249551531430196,"SGF29","SAGA complex associated factor 29",TRUE
+"223672_at",0.796574238955031,0.32938398835528,0.997305545207798,-5.46651590033862,0.799190633764818,"SGIP1","SH3 domain GRB2 like endophilin interacting protein 1",TRUE
+"201739_at",0.522667179791589,0.0384350545009412,2.20115535906508,-3.82066420213585,2.92309248911864,"SGK1","serum/glucocorticoid regulated kinase 1",TRUE
+"230573_at",0.879126527961063,0.532814188514783,0.633622401007412,-5.74600800128917,0.608728142330389,"SGK2","SGK2, serine/threonine kinase 2",TRUE
+"220357_s_at",0.966769992359004,0.845424942223767,-0.197256784999481,-5.92074948837622,-0.0772592148209608,"SGK2","SGK2, serine/threonine kinase 2",TRUE
+"235085_at",0.961778365989609,0.826622560262569,-0.22164208978582,-5.915784684474,-0.153007271698661,"SGK223","homolog of rat pragma of Rnd2",TRUE
+"1553292_s_at",0.953902670233338,0.787251032262257,0.2731720446115,-5.90340260244237,0.134525755430968,"SGK494","uncharacterized serine/threonine-protein kinase SgK494",TRUE
+"244547_at",0.96846445221933,0.852177865501088,0.18852930565715,-5.92238646324848,0.085480769002368,"SGK494","uncharacterized serine/threonine-protein kinase SgK494",TRUE
+"212989_at",0.979588787486838,0.901879170916553,0.124708111917087,-5.93211145753543,0.0485536335824168,"SGMS1","sphingomyelin synthase 1",TRUE
+"242963_at",0.707898177720919,0.179865558376693,1.38491689027936,-5.0463289179295,1.4251957290495,"SGMS2","sphingomyelin synthase 2",TRUE
+"243141_at",0.856148000488586,0.469590211661739,0.735767516878014,-5.6793947103556,0.569735514436468,"SGMS2","sphingomyelin synthase 2",TRUE
+"227038_at",0.861659105448003,0.483044513186303,0.713401613217987,-5.69479109642999,0.601820585929687,"SGMS2","sphingomyelin synthase 2",TRUE
+"1553690_at",0.8920930097751,0.5636477293945,0.586227471776645,-5.77367015004838,0.187510063607536,"SGO1","shugoshin 1",TRUE
+"231938_at",0.908801761853008,0.621252050321149,-0.501086629283161,-5.81812232218515,-0.156598088339423,"SGO1","shugoshin 1",TRUE
+"235425_at",0.774230543658252,0.286481901692925,1.09219396869888,-5.37479606379164,0.345494592188794,"SGO2","shugoshin 2",TRUE
+"230165_at",0.877488742289724,0.527511934038089,0.641918883151089,-5.74095287888202,0.197970855783467,"SGO2","shugoshin 2",TRUE
+"212321_at",0.627092759817312,0.0984931050251713,1.72477133455943,-4.58613937035608,0.563818225274463,"SGPL1","sphingosine-1-phosphate lyase 1",TRUE
+"212322_at",0.914242258486146,0.639149109484169,0.475408620185046,-5.83019624534497,0.141101647245316,"SGPL1","sphingosine-1-phosphate lyase 1",TRUE
+"208381_s_at",0.941106542715586,0.735799475859355,-0.341695691925969,-5.88297541387942,-0.251365103478871,"SGPL1","sphingosine-1-phosphate lyase 1",TRUE
+"223391_at",0.881466832418197,0.538244783550467,0.62517125542187,-5.75109230736527,0.920668965279093,"SGPP1","sphingosine-1-phosphate phosphatase 1",TRUE
+"221268_s_at",0.908667507590078,0.620226526110215,0.502568241402789,-5.81740673812812,0.491817453342279,"SGPP1","sphingosine-1-phosphate phosphatase 1",TRUE
+"244780_at",0.544577979658206,0.0467091709599733,2.10650612837915,-3.98255428822296,2.16375178052801,"SGPP2","sphingosine-1-phosphate phosphatase 2",TRUE
+"226560_at",0.776005784296548,0.293370636697021,1.07630634259848,-5.39067376230867,0.77892837530145,"SGPP2","sphingosine-1-phosphate phosphatase 2",TRUE
+"238567_at",0.851319596585235,0.455279754199564,0.759976422661127,-5.66222181114138,0.641909470598925,"SGPP2","sphingosine-1-phosphate phosphatase 2",TRUE
+"35626_at",0.5897618614591,0.0679322981349353,-1.91918245279198,-4.28917335829439,-0.751984763657271,"SGSH","N-sulfoglucosamine sulfohydrolase",TRUE
+"204293_at",0.678611044120554,0.14616333281558,-1.50611164256688,-4.89139493486041,-1.24992398764488,"SGSH","N-sulfoglucosamine sulfohydrolase",TRUE
+"230287_at",0.816800680706682,0.368902931827194,0.91722206272298,-5.53802161673321,0.667054915529483,"SGSM1","small G protein signaling modulator 1",TRUE
+"1562239_at",0.955396260969248,0.795737783774186,-0.262005308555279,-5.90630336383773,-0.160697308593176,"SGSM1","small G protein signaling modulator 1",TRUE
+"242921_at",0.978276691813018,0.895338575170904,0.133070799431793,-5.93106232459198,0.081214778860911,"SGSM1","small G protein signaling modulator 1",TRUE
+"217538_at",0.775351898377291,0.292293739342062,1.07877219737229,-5.38822306224208,0.36887205130519,"SGSM2","small G protein signaling modulator 2",TRUE
+"212319_at",0.783460137997692,0.306076059398824,-1.04769068562717,-5.41874601340003,-0.362369153637143,"SGSM2","small G protein signaling modulator 2",TRUE
+"36129_at",0.948567563026335,0.766055865796406,0.30121946933046,-5.89558706867248,0.11570827956522,"SGSM2","small G protein signaling modulator 2",TRUE
+"214779_s_at",0.937623890519979,0.723510756415958,-0.358298964903233,-5.8773479242708,-0.173550095197239,"SGSM3","small G protein signaling modulator 3",TRUE
+"215519_x_at",0.992342196993659,0.964039442057853,-0.045597621606741,-5.93867085754203,-0.019590441900375,"SGSM3","small G protein signaling modulator 3",TRUE
+"203014_x_at",0.999134201687551,0.997228417779553,0.00351307329547063,-5.93967746957166,0.00175299841977861,"SGSM3","small G protein signaling modulator 3",TRUE
+"201396_s_at",0.933690722965564,0.706496916320226,-0.381458117474249,-5.86905822505497,-0.153231867485367,"SGTA","small glutamine rich tetratricopeptide repeat containing alpha",TRUE
+"228745_at",0.774230543658252,0.286161825481418,1.09293882765638,-5.37404658170488,0.692300712794312,"SGTB","small glutamine rich tetratricopeptide repeat containing beta",TRUE
+"232084_at",0.89961817630669,0.590549748768393,0.545958567686509,-5.79553778203364,0.197972701709636,"SGTB","small glutamine rich tetratricopeptide repeat containing beta",TRUE
+"209322_s_at",0.588984479037728,0.0676575853978557,-1.92125207505085,-4.28589149254507,-0.632720483027905,"SH2B1","SH2B adaptor protein 1",TRUE
+"40149_at",0.837609393049242,0.421789621438359,-0.818497044748685,-5.61854558544014,-0.234349423469217,"SH2B1","SH2B adaptor protein 1",TRUE
+"205367_at",0.823074246722209,0.389415996333146,0.877905043729186,-5.57110968952834,0.25614564265501,"SH2B2","SH2B adaptor protein 2",TRUE
+"203320_at",0.405131078482972,0.015111786791504,2.63377756512147,-3.02973271503947,1.39923762094927,"SH2B3","SH2B adaptor protein 3",TRUE
+"211209_x_at",0.774230543658252,0.287547213600786,-1.08971916714265,-5.37728295756266,-0.651344402334094,"SH2D1A","SH2 domain containing 1A",TRUE
+"211211_x_at",0.795924451457704,0.328166893629831,0.999873847624561,-5.46413246191131,0.648033319994396,"SH2D1A","SH2 domain containing 1A",TRUE
+"210116_at",0.940301848276502,0.733168872315968,0.345241508521073,-5.88179575831024,0.266702041228631,"SH2D1A","SH2 domain containing 1A",TRUE
+"211210_x_at",0.942684843065067,0.743279352838516,-0.331637676006588,-5.88625606676468,-0.255141153844773,"SH2D1A","SH2 domain containing 1A",TRUE
+"1553177_at",0.64513208805899,0.115821137022665,1.6366932678355,-4.71293110796817,0.625435848385023,"SH2D1B","SH2 domain containing 1B",TRUE
+"1553176_at",0.712055111306836,0.186150624760166,1.36436739401532,-5.0715376720432,0.895561314970927,"SH2D1B","SH2 domain containing 1B",TRUE
+"207351_s_at",0.329541287798136,0.00786114228303402,2.9218727480458,-2.46517000765863,1.46225425500038,"SH2D2A","SH2 domain containing 2A",TRUE
+"219513_s_at",0.561683712684032,0.0548131808795147,2.0274401913975,-4.11428551531239,0.930263451018478,"SH2D3A","SH2 domain containing 3A",TRUE
+"222169_x_at",0.79943091106207,0.334039711091397,0.987541230134091,-5.47552654144794,0.359564484158398,"SH2D3A","SH2 domain containing 3A",TRUE
+"215639_at",0.596382916302699,0.0729403679708364,1.88268432939176,-4.34664438584364,1.38342085789986,"SH2D3C","SH2 domain containing 3C",TRUE
+"1552667_a_at",0.921462951426584,0.665256645297879,-0.438518318631602,-5.84645361075774,-0.304746369219263,"SH2D3C","SH2 domain containing 3C",TRUE
+"226673_at",0.986421906591669,0.936422358221825,-0.080677987283201,-5.93651371440709,-0.0615085441658216,"SH2D3C","SH2 domain containing 3C",TRUE
+"219749_at",0.590570903980459,0.0682578052383309,1.91673965512596,-4.29304382716443,1.17520399016621,"SH2D4A","SH2 domain containing 4A",TRUE
+"1563849_at",0.866667221107408,0.49796558376796,0.68901608681199,-5.71106175944597,0.2314348876082,"SH2D4B","SH2 domain containing 4B",TRUE
+"230973_at",0.672329541745581,0.1381443631406,1.53826195028087,-4.84854066436675,1.27995897048389,"SH2D5","SH2 domain containing 5",TRUE
+"242543_at",0.989669132517581,0.950308943168735,0.063028528568693,-5.93774876121174,0.0291917181053929,"SH2D6","SH2 domain containing 6",TRUE
+"204979_s_at",0.704331267592907,0.176211622928126,-1.39712703694606,-5.0312023907669,-1.37020303418045,"SH3BGR","SH3 domain binding glutamate rich protein",TRUE
+"201311_s_at",0.980131067189867,0.906578661727041,-0.118705081781313,-5.93282265424527,-0.113839318284507,"SH3BGRL","SH3 domain binding glutamate rich protein like",TRUE
+"201312_s_at",0.985498770484702,0.929837299089834,0.0890562469198753,-5.93582131385386,0.0796719716753511,"SH3BGRL","SH3 domain binding glutamate rich protein like",TRUE
+"225354_s_at",0.55937703282623,0.0530273628640673,2.04391920785436,-4.0871017506732,2.27844804714755,"SH3BGRL2","SH3 domain binding glutamate rich protein like 2",TRUE
+"244635_s_at",0.944757276318748,0.751434104714648,0.320711746138827,-5.88970989966547,0.332272561823392,"SH3BGRL2","SH3 domain binding glutamate rich protein like 2",TRUE
+"221269_s_at",0.726636642789909,0.206192702369602,1.302290014686,-5.14576938823288,0.694242268062427,"SH3BGRL3","SH3 domain binding glutamate rich protein like 3",TRUE
+"213633_at",0.595453032706696,0.0721712712730157,1.88814386538943,-4.33809671831536,1.14252125228006,"SH3BP1","SH3 domain binding protein 1",TRUE
+"209370_s_at",0.506048720491709,0.0330979464925167,-2.27257895546062,-3.69562697424556,-1.31075736279758,"SH3BP2","SH3 domain binding protein 2",TRUE
+"209371_s_at",0.831875452294783,0.407579187723161,0.844202498071735,-5.59840084737456,0.316878500817324,"SH3BP2","SH3 domain binding protein 2",TRUE
+"217253_at",0.95279845708016,0.7839871419684,0.277476006434539,-5.90225248163052,0.117503855157183,"SH3BP2","SH3 domain binding protein 2",TRUE
+"211250_s_at",0.972792809990898,0.86817421423879,0.167913966782296,-5.9259600103074,0.0671414395863952,"SH3BP2","SH3 domain binding protein 2",TRUE
+"217257_at",0.992342196993659,0.964088414143657,0.0455354805972473,-5.93867361555467,0.0345202617234097,"SH3BP2","SH3 domain binding protein 2",TRUE
+"222258_s_at",0.948429371744093,0.7657862468224,-0.301577799194414,-5.89548232165888,-0.135141717121961,"SH3BP4","SH3 domain binding protein 4",TRUE
+"231468_at",0.969882914559333,0.856210803986895,0.183324316954927,-5.9233276023945,0.129760975462623,"SH3BP4","SH3 domain binding protein 4",TRUE
+"201811_x_at",0.841813886364358,0.434076287987582,-0.796705995254516,-5.63516519968483,-0.46761404857277,"SH3BP5","SH3 domain binding protein 5",TRUE
+"201810_s_at",0.957430653957785,0.807866589660512,-0.246104917924257,-5.9102262024742,-0.119693748837934,"SH3BP5","SH3 domain binding protein 5",TRUE
+"227591_at",0.980009054680439,0.905428423717268,-0.120173949930479,-5.93265187009699,-0.0776821304756279,"SH3BP5-AS1","SH3BP5 antisense RNA 1",TRUE
+"223265_at",0.691626147814603,0.161251308375015,-1.4493347730415,-4.96529522388889,-0.579961725175046,"SH3BP5L","SH3 binding domain protein 5 like",TRUE
+"1558647_at",0.918775990454959,0.655121469828999,0.452763329799014,-5.84032838264103,0.186802753136866,"SH3D19","SH3 domain containing 19",TRUE
+"225162_at",0.937623890519979,0.723882431914296,0.357795310323278,-5.87752251131183,0.199488289963885,"SH3D19","SH3 domain containing 19",TRUE
+"220193_at",0.55679801038721,0.0520420667665281,2.05322442447678,-4.07168796301308,1.05689131072858,"SH3D21","SH3 domain containing 21",TRUE
+"201851_at",0.774230543658252,0.288506751816795,-1.08749573943325,-5.37951296217419,-0.34353922761486,"SH3GL1","SH3 domain containing GRB2 like 1, endophilin A2",TRUE
+"1566251_at",0.985954596776805,0.931603117038619,0.0868089574441221,-5.93601373922862,0.0422036480284111,"SH3GL1P1","SH3 domain containing GRB2 like 1, endophilin A2 pseudogene 1",TRUE
+"1567030_at",0.615637099066718,0.0859845536313182,1.79698179298193,-4.47850983882661,1.27789773109152,"SH3GL1P2","SH3 domain containing GRB2 like 1, endophilin A2 pseudogene 2",TRUE
+"1567027_at",0.700963156261921,0.172706994258861,1.40902926194016,-5.01635182511029,0.634473321970212,"SH3GL1P2","SH3 domain containing GRB2 like 1, endophilin A2 pseudogene 2",TRUE
+"1567028_s_at",0.802679132489125,0.340391961562673,0.974368908670787,-5.48755425159514,0.3683342392042,"SH3GL1P2","SH3 domain containing GRB2 like 1, endophilin A2 pseudogene 2",TRUE
+"1566253_at",0.929972194057784,0.690983161484656,-0.402761827127178,-5.860980890017,-0.291908892132961,"SH3GL1P2///SH3GL1P1","SH3 domain containing GRB2 like 1, endophilin A2 pseudogene 2///SH3 domain containing GRB2 like 1, endophilin A2 pseudogene 1",TRUE
+"205751_at",0.992473381533485,0.964954595133763,0.0444364078415607,-5.93872177441134,0.0601868814921476,"SH3GL2","SH3 domain containing GRB2 like 2, endophilin A1",TRUE
+"211565_at",0.472058131230383,0.0257808062158925,-2.38994501062039,-3.48512392059859,-1.08389176107677,"SH3GL3","SH3 domain containing GRB2 like 3, endophilin A3",TRUE
+"205636_at",0.831325597814571,0.405498351497335,0.848014021323684,-5.59536432127878,0.527009029864014,"SH3GL3","SH3 domain containing GRB2 like 3, endophilin A3",TRUE
+"205637_s_at",0.963573185364259,0.83405696516779,-0.211984617930801,-5.91781976324487,-0.0860543860097582,"SH3GL3","SH3 domain containing GRB2 like 3, endophilin A3",TRUE
+"210101_x_at",0.682825347106105,0.150987050248283,1.48746138005128,-4.91592241732724,0.467534622630593,"SH3GLB1","SH3 domain containing GRB2 like endophilin B1",TRUE
+"209091_s_at",0.721317419960934,0.197561752144512,1.32841676541794,-5.11488148281639,0.421687857795863,"SH3GLB1","SH3 domain containing GRB2 like endophilin B1",TRUE
+"209090_s_at",0.954054753819891,0.788978433696087,0.270896325739774,-5.90400351416833,0.12756500317904,"SH3GLB1","SH3 domain containing GRB2 like endophilin B1",TRUE
+"244863_at",0.559167054471987,0.0529350219307907,2.04478469666904,-4.08567003576784,1.11194702055247,"SH3GLB2","SH3 domain containing GRB2 like endophilin B2",TRUE
+"224907_s_at",0.89316156038085,0.567425090074602,-0.58051537525773,-5.77686376746159,-0.243509448425863,"SH3GLB2","SH3 domain containing GRB2 like endophilin B2",TRUE
+"224432_at",0.952082954955992,0.780863953636297,0.281599447348055,-5.90113386216462,0.15817065294512,"SH3GLB2","SH3 domain containing GRB2 like endophilin B2",TRUE
+"218813_s_at",0.971525376569422,0.864426376682865,-0.172736989582661,-5.92516089920529,-0.0728045031951279,"SH3GLB2","SH3 domain containing GRB2 like endophilin B2",TRUE
+"235692_at",0.457032025390949,0.0226141151773652,2.45060386497908,-3.37401335600828,2.11202494493536,"SH3KBP1","SH3 domain containing kinase binding protein 1",TRUE
+"223082_at",0.592111379991983,0.0692379164249908,1.90944560167094,-4.30458046520234,1.4494422427046,"SH3KBP1","SH3 domain containing kinase binding protein 1",TRUE
+"1554168_a_at",0.599286814317722,0.0758985535683777,1.86214333988727,-4.37864786503132,2.25439310167385,"SH3KBP1","SH3 domain containing kinase binding protein 1",TRUE
+"1553588_at",0.993213867476782,0.967653153063911,-0.0410126366993577,-5.93886425605747,-0.00915325524437982,"SH3KBP1///ND3","SH3 domain containing kinase binding protein 1///NADH dehydrogenase, subunit 3 (complex I)",TRUE
+"213252_at",0.455234810916548,0.022157438665642,2.45999426547536,-3.35667797735715,1.38550116970092,"SH3PXD2A","SH3 and PX domains 2A",TRUE
+"224817_at",0.51531387545335,0.035451442688096,2.23987845339387,-3.75317166295791,1.56044874569021,"SH3PXD2A","SH3 and PX domains 2A",TRUE
+"207661_s_at",0.626983082753167,0.0974715850637818,1.73036418280351,-4.57791985017813,1.46407900005559,"SH3PXD2A","SH3 and PX domains 2A",TRUE
+"1557389_at",0.535335724323464,0.0428610674817275,2.14846368170763,-3.91133912145944,1.77437343608377,"SH3PXD2A-AS1","SH3PXD2A antisense RNA 1",TRUE
+"231823_s_at",0.620223198657182,0.0899982025536423,1.77288027967299,-4.51479336755067,1.44363665273668,"SH3PXD2B","SH3 and PX domains 2B",TRUE
+"1562910_at",0.703902004301726,0.175666498688735,-1.39896588410798,-5.02891482671201,-0.485502989245832,"SH3PXD2B","SH3 and PX domains 2B",TRUE
+"225590_at",0.858616161893971,0.474386410946375,0.727751932336171,-5.68496445395806,0.54701258359851,"SH3RF1","SH3 domain containing ring finger 1",TRUE
+"225589_at",0.993223654424259,0.967704969569094,0.040946900023812,-5.93886688001822,0.0224356706909266,"SH3RF1","SH3 domain containing ring finger 1",TRUE
+"243582_at",0.375303125240837,0.0114289840608321,2.75809664717996,-2.78927355708783,2.40040735822307,"SH3RF2","SH3 domain containing ring finger 2",TRUE
+"235768_at",0.376193411416669,0.0114834787327764,2.75599536377978,-2.7933797508322,2.64601143159556,"SH3RF2","SH3 domain containing ring finger 2",TRUE
+"238827_at",0.421017773852716,0.0174798417310593,2.56817906835377,-3.15447036048511,2.33225748219209,"SH3RF2","SH3 domain containing ring finger 2",TRUE
+"228892_at",0.455234810916548,0.0221502415095513,2.46014369047341,-3.35640184083332,3.03676472531388,"SH3RF2","SH3 domain containing ring finger 2",TRUE
+"228461_at",0.844823091964988,0.441842090804551,-0.783129203770344,-5.64530669054596,-0.83126215436434,"SH3RF3","SH3 domain containing ring finger 3",TRUE
+"233512_at",0.736138636265353,0.221575373333679,1.25775490229145,-5.19721718746301,0.890732372723714,"SH3RF3-AS1","SH3RF3 antisense RNA 1",TRUE
+"229832_x_at",0.399719600134805,0.0142304146451783,2.66068941874279,-2.97811887164713,1.15159075452368,"SH3TC1","SH3 domain and tetratricopeptide repeats 1",TRUE
+"219256_s_at",0.991689960875868,0.961340002386961,0.0490232504297529,-5.93851299990629,0.0310208697426955,"SH3TC1","SH3 domain and tetratricopeptide repeats 1",TRUE
+"219710_at",0.519329471216548,0.0373860228387441,2.21444846015876,-3.79757547771747,2.35346927541547,"SH3TC2","SH3 domain and tetratricopeptide repeats 2",TRUE
+"240966_at",0.662575055303091,0.130428604234859,1.57068176020853,-4.8046022958401,1.65811881140131,"SH3TC2","SH3 domain and tetratricopeptide repeats 2",TRUE
+"233561_at",0.868045863234681,0.501914317160092,0.682632783759283,-5.71523164990657,0.30199182255279,"SH3TC2","SH3 domain and tetratricopeptide repeats 2",TRUE
+"204019_s_at",0.770075820151416,0.278723947062752,1.11042007102979,-5.35632643770739,0.964621447952853,"SH3YL1","SH3 and SYLF domain containing 1",TRUE
+"1554198_at",0.997039490727282,0.984776826874664,-0.0192970919455544,-5.93950211090038,-0.0136500155258013,"SH3YL1","SH3 and SYLF domain containing 1",TRUE
+"220563_s_at",0.960699983781935,0.821600839706608,-0.228177588733368,-5.91435630202882,-0.151942096017908,"SHANK1","SH3 and multiple ankyrin repeat domains 1",TRUE
+"215830_at",0.736729371800085,0.222186764405289,1.25603461384553,-5.19917380335417,0.483602851320134,"SHANK2","SH3 and multiple ankyrin repeat domains 2",TRUE
+"213307_at",0.789503009592599,0.316427182551934,-1.02499390409909,-5.44052788744688,-0.758467066838151,"SHANK2","SH3 and multiple ankyrin repeat domains 2",TRUE
+"243681_at",0.79782885150643,0.331651653169422,-0.992537807626741,-5.47092569878169,-0.921259166542701,"SHANK2","SH3 and multiple ankyrin repeat domains 2",TRUE
+"213308_at",0.83647834188245,0.418170324987161,-0.824991512030304,-5.61351105645379,-0.822343368420686,"SHANK2","SH3 and multiple ankyrin repeat domains 2",TRUE
+"1564377_at",0.976994788692278,0.89033099773987,-0.139479940326623,-5.93021227622099,-0.0531077563217388,"SHANK2","SH3 and multiple ankyrin repeat domains 2",TRUE
+"215829_at",0.983051865094694,0.917658913410206,-0.104568660917539,-5.93435904087941,-0.0678599199116912,"SHANK2","SH3 and multiple ankyrin repeat domains 2",TRUE
+"240584_at",0.841738620491136,0.433593534659577,-0.797554904230304,-5.63452564026015,-0.250936142733013,"SHANK2-AS2","SHANK2 antisense RNA 2",TRUE
+"224139_at",0.832792886465252,0.409695451169665,0.840338777105345,-5.60146592569841,0.555159703054079,"SHANK2-AS3","SHANK2 antisense RNA 3",TRUE
+"229698_at",0.623503825356688,0.094525675436144,1.74677839406273,-4.55368271549129,1.25112770863942,"SHANK3","SH3 and multiple ankyrin repeat domains 3",TRUE
+"227923_at",0.708953599456542,0.181533614858557,1.37940827706335,-5.05311723206529,1.6729640860532,"SHANK3","SH3 and multiple ankyrin repeat domains 3",TRUE
+"220973_s_at",0.900831880406409,0.596589577617284,0.537044127098426,-5.80017447585706,0.306191357567487,"SHARPIN","SHANK associated RH domain interactor",TRUE
+"1557458_s_at",0.697699759202153,0.168379943356835,-1.42399385526301,-4.99753327182537,-0.546128795768198,"SHB","SH2 domain containing adaptor protein B",TRUE
+"204656_at",0.76174779017913,0.260890600166582,-1.15376529352258,-5.31131686200878,-0.447145906177024,"SHB","SH2 domain containing adaptor protein B",TRUE
+"243595_at",0.813392555634619,0.363263272491744,-0.928283990916751,-5.52847121601536,-0.554278042291022,"SHB","SH2 domain containing adaptor protein B",TRUE
+"204657_s_at",0.944646698916914,0.751011627136476,-0.321276802880267,-5.88953408606864,-0.125394097400639,"SHB","SH2 domain containing adaptor protein B",TRUE
+"215689_s_at",0.816800680706682,0.368524949554202,0.917959920427118,-5.53738786436612,0.268333530767902,"SHBG","sex hormone binding globulin",TRUE
+"201469_s_at",0.83030603167465,0.402504506554097,0.853519912935607,-5.59095542246969,0.333378712843471,"SHC1","SHC adaptor protein 1",TRUE
+"214853_s_at",0.954456115752166,0.791166520657779,0.268015783911319,-5.90475697353004,0.104291787150766,"SHC1","SHC adaptor protein 1",TRUE
+"217048_at",0.968269082055813,0.850872087111836,0.190215704305928,-5.92207590555487,0.066859558015433,"SHC1P1","SHC adaptor protein 1 pseudogene 1",TRUE
+"213464_at",0.73957587762701,0.227917167703456,-1.24008413521035,-5.21720596079201,-0.987144691672896,"SHC2","SHC adaptor protein 2",TRUE
+"243881_at",0.612420348961838,0.0842147231648957,1.80791903442246,-4.4619270300631,1.01823722630713,"SHC3","SHC adaptor protein 3",TRUE
+"229824_at",0.916340239998123,0.646552230829302,0.464881971682351,-5.83496639049629,0.461783820271099,"SHC3","SHC adaptor protein 3",TRUE
+"206330_s_at",0.99874554378549,0.994686503105702,-0.0067350740205542,-5.93966138699443,-0.00475761796790231,"SHC3","SHC adaptor protein 3",TRUE
+"235238_at",0.895366192695711,0.57370107486695,0.571067690835326,-5.78207948305342,0.633828589690219,"SHC4","SHC adaptor protein 4",TRUE
+"230538_at",0.969829083058377,0.855571403974647,-0.184149189604676,-5.92318020424628,-0.183285382781385,"SHC4","SHC adaptor protein 4",TRUE
+"219493_at",0.990797621966014,0.953404508195467,-0.0590971499177942,-5.93798256901139,-0.0263703933792847,"SHCBP1","SHC binding and spindle associated 1",TRUE
+"220996_s_at",0.54295328972902,0.0462290908387238,-2.11156688882185,-3.97401192082042,-1.244384051175,"SHCBP1L","SHC binding and spindle associated 1 like",TRUE
+"227845_s_at",0.859465912277024,0.476554830743563,0.724143627224457,-5.68745281748616,0.462827324179429,"SHD","Src homology 2 domain containing transforming protein D",TRUE
+"238036_at",0.60020024844319,0.0765248455765428,-1.85788429683414,-4.38525249704992,-0.855230339320558,"SHE","Src homology 2 domain containing E",TRUE
+"229910_at",0.975398143273847,0.88187440334593,0.150317183616923,-5.92868415347636,0.0676991982452506,"SHE","Src homology 2 domain containing E",TRUE
+"228922_at",0.797832541094897,0.331667779177795,0.992503983722617,-5.47095691475444,0.615616072167186,"SHF","Src homology 2 domain containing F",TRUE
+"202276_at",0.7994347047598,0.334575915022262,0.986422709819083,-5.4765535804533,0.436924624813141,"SHFM1","split hand/foot malformation (ectrodactyly) type 1",TRUE
+"207586_at",0.950358151876194,0.77447019323266,0.29005657892032,-5.8987883614427,0.268488264049801,"SHH","sonic hedgehog",TRUE
+"236263_at",0.968980656821882,0.85360682149527,-0.186684465181113,-5.92272304194495,-0.1459203463,"SHH","sonic hedgehog",TRUE
+"230493_at",0.605569478807141,0.0791255300703835,-1.84051698792746,-4.41207314701282,-2.68030780939845,"SHISA2","shisa family member 2",TRUE
+"229485_x_at",0.990739624391638,0.953120991851931,0.0594571760242119,-5.93796178338546,0.0599058149683263,"SHISA3","shisa family member 3",TRUE
+"226674_at",0.952609276048235,0.782594437169795,0.279314136597901,-5.90175585118087,0.211077533671702,"SHISA4","shisa family member 4",TRUE
+"222986_s_at",0.851319596585235,0.454891005971057,-0.760640373845575,-5.66174341610966,-0.259911208707395,"SHISA5","shisa family member 5",TRUE
+"229266_at",0.784708646973769,0.308703527013724,-1.04187879783289,-5.42436453929143,-0.77223765533414,"SHISA6","shisa family member 6",TRUE
+"217479_at",0.787781415608703,0.313576505379255,1.0311917182828,-5.43462258754903,0.619156715719594,"SHISA6","shisa family member 6",TRUE
+"217481_x_at",0.961212424803935,0.823347718369717,-0.225902982133243,-5.91485812045364,-0.0950664642338017,"SHISA6","shisa family member 6",TRUE
+"238136_at",0.62986301194198,0.101046620948962,1.71100416938068,-4.60628763050283,0.974841566587169,"SHISA7","shisa family member 7",TRUE
+"244467_at",0.996666735634539,0.983400410468758,-0.0210421132477423,-5.93946782584982,-0.0156297500147682,"SHISA8","shisa family member 8",TRUE
+"1556619_at",0.821896104057596,0.384946656873889,-0.88635338563299,-5.56411299689675,-0.410248450812476,"SHISA9","shisa family member 9",TRUE
+"229978_at",0.909732972837956,0.624527340597009,-0.496362280653788,-5.82039029863162,-0.645201379963407,"SHISA9","shisa family member 9",TRUE
+"224846_at",0.955515814503015,0.796082793714598,0.261552078801789,-5.90641855935242,0.0943075116019934,"SHKBP1","SH3KBP1 binding protein 1",TRUE
+"217304_at",0.69227042558579,0.161600837986265,1.44807143670128,-4.96691339275671,0.357582142387423,"SHMT1","serine hydroxymethyltransferase 1",TRUE
+"231701_s_at",0.769847953580141,0.278496985347263,1.11095879289621,-5.3557763883948,0.92499625441363,"SHMT1","serine hydroxymethyltransferase 1",TRUE
+"214096_s_at",0.78809916745704,0.314246731128765,-1.02973099561014,-5.43601726267139,-0.347533906558668,"SHMT2","serine hydroxymethyltransferase 2",TRUE
+"214095_at",0.827060995001753,0.39580297072816,-0.86594047883828,-5.58091195825757,-0.272205070525553,"SHMT2","serine hydroxymethyltransferase 2",TRUE
+"214437_s_at",0.883276865022197,0.541193872487309,-0.62060103304138,-5.75381441746866,-0.240943740194581,"SHMT2","serine hydroxymethyltransferase 2",TRUE
+"202777_at",0.913300726876965,0.636564262825979,-0.479096880098232,-5.82850018925346,-0.252345499039007,"SHOC2","SHOC2, leucine rich repeat scaffold protein",TRUE
+"207570_at",0.95436083758186,0.789945394885387,0.26962306705002,-5.90433754504797,0.124577238404709,"SHOX","short stature homeobox",TRUE
+"210134_x_at",0.540986404840943,0.0451250397545409,2.12338704982694,-3.95400909930805,1.80768912416872,"SHOX2","short stature homeobox 2",TRUE
+"210135_s_at",0.720952283360079,0.197084094097881,1.32988850101942,-5.11312616018105,1.71940154508553,"SHOX2","short stature homeobox 2",TRUE
+"208443_x_at",0.722160153958635,0.198398797785525,1.3258443998289,-5.11794558511491,0.977893125275555,"SHOX2","short stature homeobox 2",TRUE
+"219713_at",0.957390359236635,0.806962547980023,0.247287795738111,-5.9099427726358,0.0810591601421393,"SHPK","sedoheptulokinase",TRUE
+"219632_s_at",0.7083523771159,0.180252305539688,1.38363609164685,-5.04790925994135,0.581253093013308,"SHPK///TRPV1","sedoheptulokinase///transient receptor potential cation channel subfamily V member 1",TRUE
+"219712_s_at",0.913627134030439,0.637827828841761,0.477293086860938,-5.82933127036533,0.217294811713066,"SHPK///TRPV1","sedoheptulokinase///transient receptor potential cation channel subfamily V member 1",TRUE
+"226366_at",0.916107385524794,0.646214585427534,-0.46536090892808,-5.83475163100542,-0.160638006974935,"SHPRH","SNF2 histone linker PHD RING helicase",TRUE
+"63009_at",0.940227139261806,0.732689253121812,-0.345888477265605,-5.88157921990604,-0.116734814279598,"SHQ1","SHQ1, H/ACA ribonucleoprotein assembly factor",TRUE
+"219083_at",0.97928472590149,0.899787929554842,-0.127380915710854,-5.93178353309079,-0.0407762524532043,"SHQ1","SHQ1, H/ACA ribonucleoprotein assembly factor",TRUE
+"235140_at",0.784552021081681,0.308374340128077,1.04260502836172,-5.42366400769615,0.360737818886713,"SHROOM1","shroom family member 1",TRUE
+"239435_x_at",0.920086346982941,0.659651846646261,0.44638428906158,-5.84309506076003,0.205338581264664,"SHROOM1","shroom family member 1",TRUE
+"241935_at",0.965992617204023,0.840847754569818,-0.203181226845187,-5.9195962226539,-0.0957647473003309,"SHROOM1","shroom family member 1",TRUE
+"204967_at",0.682238740660165,0.149753501781932,-1.49218394708073,-4.90973484721663,-0.764632941407049,"SHROOM2","shroom family member 2",TRUE
+"228400_at",0.932490025316259,0.702126188609414,0.387441471262538,-5.86683330109924,0.219069351916351,"SHROOM3","shroom family member 3",TRUE
+"225548_at",0.956734254923335,0.803850575971203,0.251362372273061,-5.90895612041275,0.113040436193698,"SHROOM3","shroom family member 3",TRUE
+"243653_at",0.969882914559333,0.856260151701352,0.183260660222063,-5.92333894992896,0.0728290309871471,"SHROOM3","shroom family member 3",TRUE
+"244825_at",0.943974674379334,0.748929738001404,0.324062858236735,-5.88866274396678,0.102356168355638,"SHROOM4","shroom family member 4",TRUE
+"232404_at",0.97080060552614,0.860732147297397,0.177495132314231,-5.92435042894342,0.10850129424162,"SHROOM4","shroom family member 4",TRUE
+"221802_s_at",0.926430328514448,0.680365011080762,-0.417452319884963,-5.85515932622662,-0.178578539095778,"SHTN1","shootin 1",TRUE
+"206664_at",0.327864702134751,0.00772648190383342,2.92936627714882,-2.45015899607112,2.58385468627187,"SI","sucrase-isomaltase",TRUE
+"224391_s_at",0.812302873476553,0.359193232380363,-0.93633870678071,-5.5214508679726,-0.713303341736724,"SIAE","sialic acid acetylesterase",TRUE
+"1554354_at",0.833620054418102,0.411100091948336,-0.837781286499846,-5.60348755253137,-0.82145614785576,"SIAE","sialic acid acetylesterase",TRUE
+"1554355_a_at",0.877857073443889,0.52877439721126,0.639939401587826,-5.74216473727277,0.678448144317173,"SIAE","sialic acid acetylesterase",TRUE
+"223744_s_at",0.885700834453265,0.547522679537008,-0.610837840641438,-5.75956506645463,-0.345404199063383,"SIAE","sialic acid acetylesterase",TRUE
+"202981_x_at",0.736132227107113,0.221525927034465,-1.25789418952279,-5.19705866496873,-0.482562191126897,"SIAH1","siah E3 ubiquitin protein ligase 1",TRUE
+"202980_s_at",0.812302873476553,0.360884130963887,-0.932984983099616,-5.52438068775972,-0.390551643913733,"SIAH1","siah E3 ubiquitin protein ligase 1",TRUE
+"232365_at",0.948989397056643,0.769954718912165,-0.296042274572228,-5.89708668811779,-0.298335374063104,"SIAH1","siah E3 ubiquitin protein ligase 1",TRUE
+"209339_at",0.878278790222455,0.530958006220407,-0.636521665783689,-5.7442486400183,-0.467106177157447,"SIAH2","siah E3 ubiquitin protein ligase 2",TRUE
+"1560676_at",0.875220799430778,0.522331132792433,0.650069349442893,-5.73592520603914,0.461686941059006,"SIAH3","siah E3 ubiquitin protein ligase family member 3",TRUE
+"219734_at",0.764077045023402,0.264111423390896,-1.14577918994286,-5.31972377265855,-1.96183301236541,"SIDT1","SID1 transmembrane family member 1",TRUE
+"218765_at",0.523369751179323,0.0388464013986089,-2.19603263617529,-3.82953914421029,-1.08497000613995,"SIDT2","SID1 transmembrane family member 2",TRUE
+"56256_at",0.769847953580141,0.277373137579456,-1.11363110175707,-5.35304439295109,-0.47026561606101,"SIDT2","SID1 transmembrane family member 2",TRUE
+"52940_at",0.936456142259101,0.716504884678182,-0.367810425201642,-5.87400533796266,-0.185079761407009,"SIGIRR","single Ig and TIR domain containing",TRUE
+"218921_at",0.95952608973576,0.817081582335263,-0.23406785106787,-5.91303355912142,-0.118427151706507,"SIGIRR","single Ig and TIR domain containing",TRUE
+"44673_at",0.634202341398092,0.105115590303442,1.68966627190408,-4.63727620481318,0.658819355860447,"SIGLEC1","sialic acid binding Ig like lectin 1",TRUE
+"219519_s_at",0.692289844352812,0.161864509202615,1.44711988418853,-4.9681314485321,0.629533438220567,"SIGLEC1","sialic acid binding Ig like lectin 1",TRUE
+"1552806_a_at",0.622917527985155,0.0938183234193271,-1.75078475914075,-4.54774122863514,-0.974211002029584,"SIGLEC10","sialic acid binding Ig like lectin 10",TRUE
+"1552807_a_at",0.997608949249317,0.98799874359457,-0.0152125749730879,-5.93957076404094,-0.0102192958758938,"SIGLEC10","sialic acid binding Ig like lectin 10",TRUE
+"1552911_at",0.753862100951903,0.247262026721571,1.18839013739096,-5.27427619555995,0.690183230407655,"SIGLEC11","sialic acid binding Ig like lectin 11",TRUE
+"1552910_at",0.789661545166663,0.317354167420025,-1.02298694111035,-5.44243323937261,-0.698967657202995,"SIGLEC11","sialic acid binding Ig like lectin 11",TRUE
+"215856_at",0.859064198633089,0.475536737256889,-0.725836558913139,-5.68628679963082,-0.718335073268766,"SIGLEC15","sialic acid binding Ig like lectin 15",TRUE
+"1561880_a_at",0.927041268353741,0.681362275001524,-0.416068647302604,-5.85571639995162,-0.197754818328228,"SIGLEC16","sialic acid binding Ig like lectin 16 (gene/pseudogene)",TRUE
+"232686_at",0.858826390511142,0.475040254182396,0.72666290399191,-5.6857167092604,0.571185432804007,"SIGLEC17P","sialic acid binding Ig like lectin 17, pseudogene",TRUE
+"220000_at",0.977063818674184,0.890621253106177,-0.139108285073066,-5.93026265902139,-0.0728035088322851,"SIGLEC5","sialic acid binding Ig like lectin 5",TRUE
+"206519_x_at",0.689950875648652,0.159213580777378,1.45674425754017,-4.9557815389961,1.25671227294503,"SIGLEC6","sialic acid binding Ig like lectin 6",TRUE
+"206520_x_at",0.862125670830879,0.484947535131346,0.710267580758789,-5.69691240301003,0.226352892694399,"SIGLEC6","sialic acid binding Ig like lectin 6",TRUE
+"210796_x_at",0.868771271118463,0.505102901990191,0.677499003909683,-5.71855836791391,0.191028388369292,"SIGLEC6","sialic acid binding Ig like lectin 6",TRUE
+"216537_s_at",0.854184492233394,0.464374295446699,0.744539659813158,-5.67323293060665,0.366138401207897,"SIGLEC7","sialic acid binding Ig like lectin 7",TRUE
+"207224_s_at",0.888750194607196,0.555282885376026,-0.598947503253593,-5.76644979377167,-0.324058123935637,"SIGLEC7","sialic acid binding Ig like lectin 7",TRUE
+"217159_x_at",0.940227139261806,0.732712254106924,-0.345857447303694,-5.88158961468634,-0.0998201630689701,"SIGLEC7","sialic acid binding Ig like lectin 7",TRUE
+"208253_at",0.580748061056528,0.0634124313422357,1.95421225727817,-4.23329754379693,1.42279734346516,"SIGLEC8","sialic acid binding Ig like lectin 8",TRUE
+"216328_at",0.784925710185113,0.309843197246336,-1.03936875021125,-5.42678238076268,-0.859068532933478,"SIGLEC8","sialic acid binding Ig like lectin 8",TRUE
+"216327_s_at",0.955645941042265,0.79682854422731,0.260572598652849,-5.90666683294991,0.160366183859107,"SIGLEC8","sialic acid binding Ig like lectin 8",TRUE
+"210569_s_at",0.940227139261806,0.732710872399375,-0.345859311315501,-5.88158899028384,-0.210159144543933,"SIGLEC9","sialic acid binding Ig like lectin 9",TRUE
+"1553887_at",0.713460685500024,0.188259667301488,1.35759468999429,-5.07977718071562,0.930086341250395,"SIGLECL1","SIGLEC family like 1",TRUE
+"214484_s_at",0.832605695407954,0.409264963198631,0.84112370039998,-5.60084431098452,0.269293671447992,"SIGMAR1","sigma non-opioid intracellular receptor 1",TRUE
+"201692_at",0.852380677459291,0.458157537250547,0.755071963033646,-5.66574336738897,0.334365037241808,"SIGMAR1","sigma non-opioid intracellular receptor 1",TRUE
+"208078_s_at",0.290359003667931,0.00502751912897045,3.11406200159026,-2.07571216834211,2.06123963395403,"SIK1","salt inducible kinase 1",TRUE
+"232470_at",0.677013732819214,0.144525292706296,1.5125593247765,-4.88285847185358,0.557992251950074,"SIK1","salt inducible kinase 1",TRUE
+"1556056_at",0.640337040581689,0.111022060998507,1.65990568530596,-4.68000553149,0.469987113881691,"SIK2","salt inducible kinase 2",TRUE
+"223430_at",0.710842845257879,0.184319703694962,1.37029629475907,-5.06429666375407,0.448741380375685,"SIK2","salt inducible kinase 2",TRUE
+"215752_at",0.823074246722209,0.389416296952334,0.877904477601709,-5.5711101562971,0.313462802750625,"SIK2","salt inducible kinase 2",TRUE
+"213221_s_at",0.966313390701604,0.84300346349812,0.200390090685921,-5.92014378672524,0.0757359781556026,"SIK2","salt inducible kinase 2",TRUE
+"213034_at",0.767011398042819,0.268293213657913,1.13551671230465,-5.33045150147539,0.522237935232319,"SIK3","SIK family kinase 3",TRUE
+"204155_s_at",0.767727587789514,0.270160877230258,1.13097124017637,-5.33517583862684,0.550105630072161,"SIK3","SIK family kinase 3",TRUE
+"204157_s_at",0.768852835478002,0.272072941051125,1.12634150349515,-5.33997055086179,0.479345913320991,"SIK3","SIK family kinase 3",TRUE
+"1563455_at",0.85334340854827,0.461360793552344,0.749634486704599,-5.6696224200298,0.305400475540166,"SIK3","SIK family kinase 3",TRUE
+"1554929_at",0.95018792835023,0.773557162154924,0.291266009878948,-5.89844731131128,0.179201806285618,"SIK3","SIK family kinase 3",TRUE
+"204156_at",0.980808506518944,0.909846637436241,0.114533284432771,-5.93329626740066,0.0536495948445568,"SIK3","SIK family kinase 3",TRUE
+"204666_s_at",0.888830748858811,0.555855353038713,-0.598073817238516,-5.7669505202524,-0.289464669394899,"SIKE1","suppressor of IKBKE 1",TRUE
+"235294_at",0.899046682581382,0.589165239907457,0.548008316435828,-5.79446115168895,0.24291114769176,"SIKE1","suppressor of IKBKE 1",TRUE
+"228026_at",0.936992192746977,0.717965732936664,-0.365824292446492,-5.87471046084697,-0.182592702107542,"SIKE1","suppressor of IKBKE 1",TRUE
+"204665_at",0.959203345279235,0.815093511647503,0.236661713194965,-5.91244043532291,0.155406893089449,"SIKE1","suppressor of IKBKE 1",TRUE
+"221705_s_at",0.971282250892504,0.863806117048889,0.173535591717855,-5.92502640401829,0.0858258005789345,"SIKE1","suppressor of IKBKE 1",TRUE
+"218436_at",0.85492369444809,0.467006918676418,-0.740104846268661,-5.67635671452274,-0.286670750248287,"SIL1","SIL1 nucleotide exchange factor",TRUE
+"206876_at",0.329882019967271,0.00790981861675694,2.91919420605947,-2.47053199367807,2.74294051891184,"SIM1","single-minded family bHLH transcription factor 1",TRUE
+"1556300_s_at",0.502738256886598,0.0324584553600309,2.28183126963398,-3.67925558035774,2.84725597421714,"SIM1","single-minded family bHLH transcription factor 1",TRUE
+"1552796_a_at",0.623503825356688,0.0942249421033701,1.74847856609361,-4.55116256864816,0.829619162097534,"SIM1","single-minded family bHLH transcription factor 1",TRUE
+"208157_at",0.527546822913581,0.0400274179759651,2.18159361757037,-3.85448582296174,1.95971590414577,"SIM2","single-minded family bHLH transcription factor 2",TRUE
+"206558_at",0.54402892121853,0.0464178311382614,2.10957167215684,-3.97738133234466,1.5654900553424,"SIM2","single-minded family bHLH transcription factor 2",TRUE
+"1557900_at",0.596766912305488,0.073074613221495,1.8817365358379,-4.34812651823223,1.3987344785414,"SIM2","single-minded family bHLH transcription factor 2",TRUE
+"228805_at",0.854350135157525,0.465263379502795,0.743040277672688,-5.67429104168714,0.578810208060823,"SIMC1","SUMO interacting motifs containing 1",TRUE
+"238006_at",0.403630903577261,0.0150039856529882,-2.63698866939334,-3.02358738398199,-1.47774017042212,"SIN3A","SIN3 transcription regulator family member A",TRUE
+"238189_at",0.787929163003677,0.313932260589854,-1.03041609497935,-5.43536336259103,-0.727644380968333,"SIN3A","SIN3 transcription regulator family member A",TRUE
+"238005_s_at",0.870861660648593,0.510733524597769,-0.668477750731017,-5.72434596850869,-0.195046424022118,"SIN3A","SIN3 transcription regulator family member A",TRUE
+"225135_at",0.964181293782946,0.835513850911357,-0.210094531553129,-5.91820749322029,-0.0561968440598086,"SIN3A","SIN3 transcription regulator family member A",TRUE
+"242129_at",0.774230543658252,0.287450353566255,1.08994390684463,-5.37705732722723,0.318516476388805,"SIN3B","SIN3 transcription regulator family member B",TRUE
+"209352_s_at",0.982093200363011,0.913997812661572,-0.109237012285803,-5.93387316119753,-0.0449672529921958,"SIN3B","SIN3 transcription regulator family member B",TRUE
+"39705_at",0.98539961718117,0.928049435137468,0.0913320723882579,-5.93562143707722,0.0340276713801426,"SIN3B","SIN3 transcription regulator family member B",TRUE
+"204164_at",0.942303845415102,0.740603090497352,0.335232321849424,-5.88509472328513,0.315768436588386,"SIPA1","signal-induced proliferation-associated 1",TRUE
+"202254_at",0.84051226748197,0.429656650459142,-0.80449974901705,-5.62926942560822,-0.391335991322364,"SIPA1L1","signal induced proliferation associated 1 like 1",TRUE
+"237032_x_at",0.861659105448003,0.483007785848103,-0.71346216879599,-5.69475002111257,-0.424998191523832,"SIPA1L1","signal induced proliferation associated 1 like 1",TRUE
+"202255_s_at",0.955892698633978,0.799438147661953,0.257147148192178,-5.90752782064643,0.115203790412082,"SIPA1L1","signal induced proliferation associated 1 like 1",TRUE
+"233587_s_at",0.791348540995396,0.321781206372479,-1.01345839155375,-5.45143329579578,-0.867671455279003,"SIPA1L2","signal induced proliferation associated 1 like 2",TRUE
+"225056_at",0.856287407895097,0.470149752739053,-0.734829912053824,-5.68004920967541,-1.04109490829198,"SIPA1L2","signal induced proliferation associated 1 like 2",TRUE
+"1559469_s_at",0.917166618334994,0.649920842760401,-0.460109738555967,-5.83709446728938,-0.192208234919578,"SIPA1L2","signal induced proliferation associated 1 like 2",TRUE
+"213600_at",0.53333138995891,0.0421797743770555,-2.15624409164251,-3.89803613614542,-0.983186066315934,"SIPA1L3","signal induced proliferation associated 1 like 3",TRUE
+"37831_at",0.597346378847428,0.0733792652085856,-1.87959127590528,-4.35147927607477,-0.534269392344417,"SIPA1L3","signal induced proliferation associated 1 like 3",TRUE
+"230564_at",0.797680342481891,0.331283539766553,0.993310225636231,-5.47021257355368,0.474522914746338,"SIPA1L3","signal induced proliferation associated 1 like 3",TRUE
+"236096_at",0.970271320001985,0.858588431303533,0.180258141134404,-5.92386972046694,0.14567046035122,"SIPA1L3","signal induced proliferation associated 1 like 3",TRUE
+"202896_s_at",0.702324656770028,0.17374739360553,1.40547595122812,-5.02079621465674,1.30711281048016,"SIRPA","signal regulatory protein alpha",TRUE
+"202897_at",0.877223961993707,0.526453800352731,0.64357997593604,-5.73993316596862,0.975137224060084,"SIRPA","signal regulatory protein alpha",TRUE
+"202895_s_at",0.933227785561424,0.704661653390358,-0.383968780625398,-5.8681287860559,-0.320432609216984,"SIRPA","signal regulatory protein alpha",TRUE
+"206934_at",0.429276772897071,0.0188233529618196,2.53457890252601,-3.21775235139303,1.71515151130768,"SIRPB1","signal regulatory protein beta 1",TRUE
+"1554624_a_at",0.868397087637799,0.503335758464717,0.680341925387536,-5.71671910604614,0.614135313024681,"SIRPB1","signal regulatory protein beta 1",TRUE
+"217240_at",0.973516231900274,0.872630980320984,0.162183929177856,-5.92688006874737,0.0754591171035308,"SIRPB1","signal regulatory protein beta 1",TRUE
+"1559034_at",0.671655467883069,0.137771755867299,1.53979276706476,-4.84648224974637,1.13361442439111,"SIRPB2","signal regulatory protein beta 2",TRUE
+"232891_at",0.855405088766616,0.468213961783709,0.738076467270749,-5.67777956075046,0.490648735121836,"SIRPD","signal regulatory protein delta",TRUE
+"220485_s_at",0.657318133823516,0.126150666664045,1.58934728819912,-4.77897891989765,1.10367841752411,"SIRPG","signal regulatory protein gamma",TRUE
+"234742_at",0.986889306520757,0.939092681214965,0.0772822194482604,-5.9367748946503,0.0572906683482328,"SIRPG","signal regulatory protein gamma",TRUE
+"218878_s_at",0.815634970791029,0.366510128571364,-0.921901566149205,-5.53399439763508,-0.290977003069385,"SIRT1","sirtuin 1",TRUE
+"1558331_at",0.889725783121438,0.557919868592519,0.594926894161236,-5.76874823015343,0.439152987412594,"SIRT2","sirtuin 2",TRUE
+"220605_s_at",0.986260660718739,0.932634885461038,0.0854960776728684,-5.93612388119595,0.0245066323348233,"SIRT2","sirtuin 2",TRUE
+"221913_at",0.806221445484273,0.346791792626481,-0.96126707990584,-5.4993713898318,-0.70779484179995,"SIRT3","sirtuin 3",TRUE
+"221562_s_at",0.886011788884692,0.548136237019199,-0.609894519649738,-5.76011603628736,-0.523603947158367,"SIRT3","sirtuin 3",TRUE
+"49327_at",0.97825928502075,0.895255968447967,-0.133176479781606,-5.931048631742,-0.0405099577730965,"SIRT3","sirtuin 3",TRUE
+"220047_at",0.83030603167465,0.402594599898067,-0.853353843079053,-5.59108879359512,-0.825241496722502,"SIRT4","sirtuin 4",TRUE
+"222248_s_at",0.926006500809857,0.679206926419345,-0.419060167142614,-5.85450971417684,-0.381829557614951,"SIRT4","sirtuin 4",TRUE
+"219185_at",0.193335085181883,0.00199539921001035,3.50267549324514,-1.26519903833781,1.09192447057027,"SIRT5","sirtuin 5",TRUE
+"222081_at",0.272451700075148,0.00431039269437591,-3.17950374070572,-1.94115904591989,-2.12723255826192,"SIRT5","sirtuin 5",TRUE
+"222080_s_at",0.899331416659389,0.58982875778646,0.54702569044719,-5.79497776502016,0.348497611986866,"SIRT5","sirtuin 5",TRUE
+"221010_s_at",0.921980251030053,0.667146003123761,0.43587307551121,-5.84756988722247,0.198535596264457,"SIRT5","sirtuin 5",TRUE
+"1569938_at",0.968303740374882,0.85118115751171,0.189816492424228,-5.92214967115651,0.169239502201113,"SIRT5","sirtuin 5",TRUE
+"229112_at",0.984161165881616,0.922611013553326,0.0982578929869038,-5.93498216825561,0.0670135045366616,"SIRT5","sirtuin 5",TRUE
+"219613_s_at",0.768852835478002,0.273790736889771,-1.12220241056495,-5.34424241392269,-0.273453764271418,"SIRT6","sirtuin 6",TRUE
+"233179_x_at",0.835288731225683,0.414359295535922,0.831868382787083,-5.60813949203246,0.20460304902144,"SIRT6","sirtuin 6",TRUE
+"218797_s_at",0.729083413548563,0.21114327983307,-1.2876855317495,-5.16280872014234,-0.494048367291239,"SIRT7","sirtuin 7",TRUE
+"205484_at",0.97928472590149,0.899589020648827,0.127635189252455,-5.93175197477452,0.0615412310936625,"SIT1","signaling threshold regulating transmembrane adaptor 1",TRUE
+"210792_x_at",0.975398143273847,0.881855328924741,0.150341648099843,-5.92868057479992,0.185265469046557,"SIVA1","SIVA1 apoptosis inducing factor",TRUE
+"203489_at",0.980009054680439,0.90532920586001,0.120300665001044,-5.93263703876238,0.144229348228352,"SIVA1","SIVA1 apoptosis inducing factor",TRUE
+"222030_at",0.986342822130003,0.935423584526961,-0.0819483447729641,-5.93641312235146,-0.0357987211289714,"SIVA1","SIVA1 apoptosis inducing factor",TRUE
+"205817_at",0.594373330991186,0.0712813156160805,-1.89452523320848,-4.32808380958751,-1.6275985661953,"SIX1","SIX homeobox 1",TRUE
+"228347_at",0.622434989367596,0.0930577981805213,-1.75512127190098,-4.54129880683998,-1.69830230443795,"SIX1","SIX homeobox 1",TRUE
+"230911_at",0.640839095542136,0.111336502355621,1.65835916302303,-4.68221020270983,0.570974317721726,"SIX1","SIX homeobox 1",TRUE
+"206511_s_at",0.775351898377291,0.292038146444806,1.07935840524465,-5.38763972016584,0.70542862900257,"SIX2","SIX homeobox 2",TRUE
+"206510_at",0.788413816943444,0.314702206510722,1.02873955973225,-5.43696285396311,0.890772030471062,"SIX2","SIX homeobox 2",TRUE
+"244288_s_at",0.552986220491716,0.0504388163071273,2.0687077048139,-4.04593901782894,1.76589425750409,"SIX3","SIX homeobox 3",TRUE
+"206634_at",0.605664606439963,0.0792127001355468,1.83994351500327,-4.41295570836236,1.31912278317268,"SIX3","SIX homeobox 3",TRUE
+"242054_s_at",0.761748280722165,0.261111838758669,1.15321440601325,-5.31189842525741,1.19425930227611,"SIX3","SIX homeobox 3",TRUE
+"243440_at",0.929191341566013,0.68858459814032,0.406072311645868,-5.85968691924413,0.245750875065261,"SIX3-AS1","SIX3 antisense RNA 1",TRUE
+"231797_at",0.77796164470392,0.297064914435193,-1.06789624629021,-5.39899445217732,-0.577300908118228,"SIX4","SIX homeobox 4",TRUE
+"229796_at",0.922053973995699,0.667303271049901,-0.435653031261223,-5.84766244581253,-0.192082666686918,"SIX4","SIX homeobox 4",TRUE
+"229009_at",0.322131160460075,0.00728007161220208,-2.95513429314678,-2.39842683197327,-1.18821781318967,"SIX5","SIX homeobox 5",TRUE
+"241822_at",0.860085676417428,0.478923582211335,0.720212933542982,-5.69015012575603,0.507125923022848,"SIX5","SIX homeobox 5",TRUE
+"217661_x_at",0.994304286761558,0.974050282244932,-0.0328982666648789,-5.93915634804473,-0.02191320327948,"SIX5","SIX homeobox 5",TRUE
+"207250_at",0.66932922090261,0.13540049658088,1.54961559495016,-4.83323542637736,0.90935532159027,"SIX6","SIX homeobox 6",TRUE
+"217640_x_at",0.981372324306002,0.911791217696437,-0.112051885586033,-5.93356994842098,-0.0463881630621952,"SKA1","spindle and kinetochore associated complex subunit 1",TRUE
+"225684_at",0.891420607788025,0.561001628801513,-0.590240631631484,-5.77140831276061,-0.256667105980824,"SKA2","spindle and kinetochore associated complex subunit 2",TRUE
+"225686_at",0.947778780715578,0.762387535909617,-0.306098240233912,-5.89415030578505,-0.173333069835971,"SKA2","spindle and kinetochore associated complex subunit 2",TRUE
+"227165_at",0.998709719538178,0.994347660427316,0.00716457838524047,-5.93965847925313,0.00228914609234643,"SKA3","spindle and kinetochore associated complex subunit 3",TRUE
+"205790_at",0.895457620469779,0.574226721584757,-0.570278786833723,-5.78251125707264,-0.322194733177136,"SKAP1","src kinase associated phosphoprotein 1",TRUE
+"216899_s_at",0.66932922090261,0.135418596310297,1.54954008212072,-4.83333751508841,1.93886742805817,"SKAP2","src kinase associated phosphoprotein 2",TRUE
+"241331_at",0.698480416742743,0.169773446081196,1.41914130805336,-5.00365342807775,0.509091551328648,"SKAP2","src kinase associated phosphoprotein 2",TRUE
+"204361_s_at",0.725836505745628,0.204831186827018,1.30635418529544,-5.14099866377942,1.859394440706,"SKAP2","src kinase associated phosphoprotein 2",TRUE
+"204362_at",0.728385463227073,0.209002002735575,1.29396952063623,-5.15549706963183,2.3765391819287,"SKAP2","src kinase associated phosphoprotein 2",TRUE
+"225639_at",0.742464338584916,0.232740673049966,1.22689308145349,-5.23196861082527,2.23497248233148,"SKAP2","src kinase associated phosphoprotein 2",TRUE
+"217035_at",0.820536502908875,0.380570847862851,0.894687253542641,-5.5571502880734,0.600377252829518,"SKAP2","src kinase associated phosphoprotein 2",TRUE
+"216706_x_at",0.358427723880268,0.010013700244057,2.81629047865667,-2.6750130387534,1.41540839680746,"SKAP2///IGHG1","src kinase associated phosphoprotein 2///immunoglobulin heavy constant gamma 1 (G1m marker)",TRUE
+"213755_s_at",0.681236571898166,0.149143150720092,1.49453237477434,-4.90665203656054,0.943658933647908,"SKI","SKI proto-oncogene",TRUE
+"204270_at",0.775351898377291,0.292280157942119,1.07880333734846,-5.38819208161763,0.374764062395174,"SKI","SKI proto-oncogene",TRUE
+"229265_at",0.89316156038085,0.566929002609767,0.581264439663263,-5.7764466916797,0.249333391110119,"SKI","SKI proto-oncogene",TRUE
+"1559265_at",0.540483367247649,0.0446818196503932,-2.1282056219536,-3.94583446910988,-2.35781395850518,"SKIDA1","SKI/DACH domain containing 1",TRUE
+"1559266_s_at",0.744573608322482,0.235777441738341,-1.21869432891868,-5.24107545816178,-0.995772314098714,"SKIDA1","SKI/DACH domain containing 1",TRUE
+"225227_at",0.736223289546449,0.221617780715577,1.25763546222301,-5.19735310996221,0.615294019201498,"SKIL","SKI-like proto-oncogene",TRUE
+"206675_s_at",0.737123149977386,0.222598748959673,1.25487744335927,-5.20048865023511,0.559618024754521,"SKIL","SKI-like proto-oncogene",TRUE
+"215889_at",0.774230543658252,0.289242517173383,-1.08579444129845,-5.38121655065181,-0.818970738687312,"SKIL","SKI-like proto-oncogene",TRUE
+"217591_at",0.776955214137673,0.295696176091466,1.07100342954785,-5.39592710118111,0.595595754440142,"SKIL","SKI-like proto-oncogene",TRUE
+"232379_at",0.852994610926182,0.459283447181438,0.75315816335966,-5.66711168360447,0.354901503227916,"SKIL","SKI-like proto-oncogene",TRUE
+"203727_at",0.76772687203753,0.269582715679524,1.13237588534545,-5.33371770618564,0.311252752092923,"SKIV2L","Ski2 like RNA helicase",TRUE
+"1562142_at",0.842167419664876,0.435508763120342,0.794190451492558,-5.6370566230791,0.670609931992647,"SKIV2L2","Ski2 like RNA helicase 2",TRUE
+"227447_at",0.930827859648584,0.693810000288683,0.398866106446642,-5.86249025538537,0.148968477756956,"SKIV2L2","Ski2 like RNA helicase 2",TRUE
+"212896_at",0.973433731874338,0.871593705654872,-0.163517043615424,-5.92666885756512,-0.0572457107928894,"SKIV2L2","Ski2 like RNA helicase 2",TRUE
+"207974_s_at",0.515810181619652,0.0361202800108927,-2.23094677220273,-3.76880232064541,-0.554272712665989,"SKP1","S-phase kinase-associated protein 1",TRUE
+"200711_s_at",0.6287528932499,0.0998874738137838,-1.71721646938351,-4.59721085834326,-0.529488224410745,"SKP1","S-phase kinase-associated protein 1",TRUE
+"200719_at",0.71667985884279,0.192635156937424,-1.34373230038317,-5.09653491071745,-0.475532824592523,"SKP1","S-phase kinase-associated protein 1",TRUE
+"200718_s_at",0.871451481476429,0.512747474681205,-0.665264568759797,-5.72638944710537,-0.142059158079443,"SKP1","S-phase kinase-associated protein 1",TRUE
+"203625_x_at",0.612280302313181,0.0838598740772325,1.81013581703867,-4.45855711856271,1.01000988776858,"SKP2","S-phase kinase-associated protein 2, E3 ubiquitin protein ligase",TRUE
+"203626_s_at",0.643515428391208,0.113830330953919,1.64622238785082,-4.69945749409939,0.858342165036412,"SKP2","S-phase kinase-associated protein 2, E3 ubiquitin protein ligase",TRUE
+"210567_s_at",0.723649742218726,0.200341302336463,1.31990730214153,-5.12499851846652,0.581347137061931,"SKP2","S-phase kinase-associated protein 2, E3 ubiquitin protein ligase",TRUE
+"203761_at",0.880842449447422,0.536721832708566,0.627536637695911,-5.74967588847181,0.197861189860798,"SLA","Src-like-adaptor",TRUE
+"203760_s_at",0.973071267819624,0.869850085209482,0.165758644832916,-5.92630982306333,0.0804087088428482,"SLA","Src-like-adaptor",TRUE
+"232234_at",0.474859593446097,0.0261146554726563,2.38395765367229,-3.4960078663762,1.30047046597435,"SLA2","Src like adaptor 2",TRUE
+"1555688_s_at",0.965992617204023,0.840659877484559,0.203424561410896,-5.91954812784682,0.133520309146939,"SLA2","Src like adaptor 2",TRUE
+"225619_at",0.854163696308241,0.463847186383541,0.745429401109534,-5.6726040861318,1.1232826477787,"SLAIN1","SLAIN motif family member 1",TRUE
+"224854_s_at",0.881466832418197,0.538275304730655,-0.625123887969615,-5.75112061895427,-0.204447617185942,"SLAIN2","SLAIN motif family member 2",TRUE
+"224845_s_at",0.893395477698951,0.568098733086133,-0.579498748331504,-5.77742898811085,-0.183706637340554,"SLAIN2","SLAIN motif family member 2",TRUE
+"224843_at",0.89799228292133,0.586845190714581,0.551448457382829,-5.79264541049877,0.443841636667739,"SLAIN2","SLAIN motif family member 2",TRUE
+"233874_at",0.919354071504066,0.656778979083923,0.450427258049082,-5.84134603680822,0.298304327672589,"SLAIN2","SLAIN motif family member 2",TRUE
+"224844_at",0.927016202006999,0.681252161263368,0.416221386066042,-5.85565499584223,0.13628678133376,"SLAIN2","SLAIN motif family member 2",TRUE
+"233230_s_at",0.961212424803935,0.824168582467916,-0.224834558415584,-5.91509210676715,-0.0725379851234162,"SLAIN2","SLAIN motif family member 2",TRUE
+"224853_at",0.966064677476069,0.841802735233257,-0.201944549059219,-5.91983976446387,-0.0692614002439598,"SLAIN2","SLAIN motif family member 2",TRUE
+"206181_at",0.676433303013017,0.143167557063862,1.51794918186043,-4.87570017615597,0.676944335962908,"SLAMF1","signaling lymphocytic activation molecule family member 1",TRUE
+"239427_at",0.68041487556515,0.148024214990089,1.49885810393673,-4.90096340940013,1.04328025243206,"SLAMF1","signaling lymphocytic activation molecule family member 1",TRUE
+"1555626_a_at",0.970353888480813,0.85896950797591,-0.179766871824582,-5.92395573260007,-0.112089958372565,"SLAMF1","signaling lymphocytic activation molecule family member 1",TRUE
+"1552497_a_at",0.936456142259101,0.716267369955022,0.36813348655998,-5.87389028739804,0.127567527961525,"SLAMF6","SLAM family member 6",TRUE
+"219159_s_at",0.877339406737153,0.527202429739044,-0.642404564881146,-5.74065499016212,-0.394744454083988,"SLAMF7","SLAM family member 7",TRUE
+"234306_s_at",0.911393258378799,0.629558919844953,-0.489126821692706,-5.82382308300972,-0.306796796050356,"SLAMF7","SLAM family member 7",TRUE
+"222838_at",0.955736115035547,0.798030233593207,-0.258994828833884,-5.90706481192748,-0.207980451327941,"SLAMF7","SLAM family member 7",TRUE
+"219385_at",0.612111927345277,0.0837420615737113,1.81087359925917,-4.4574348940828,0.727323731898454,"SLAMF8","SLAM family member 8",TRUE
+"219386_s_at",0.62110896023334,0.0913893502444294,1.76474228589424,-4.52696371411059,1.13820942044011,"SLAMF8","SLAM family member 8",TRUE
+"1553769_at",0.774230543658252,0.289843917835028,1.08440614527318,-5.38260495319278,0.62572610776679,"SLAMF9","SLAM family member 9",TRUE
+"1553770_a_at",0.899808883319249,0.592832909592741,0.542583529853009,-5.79730197804084,0.339500097377776,"SLAMF9","SLAM family member 9",TRUE
+"206052_s_at",0.798535466562538,0.333074372171087,-0.9895580490398,-5.47367199822548,-0.314448989929234,"SLBP","stem-loop binding protein",TRUE
+"207185_at",0.677163945383887,0.144657208493459,1.51203786717604,-4.88354994343279,0.662890726473062,"SLC10A1","solute carrier family 10 member 1",TRUE
+"207095_at",0.622489181861932,0.0931077214582074,1.75483567950518,-4.54172345094092,0.649743064914016,"SLC10A2","solute carrier family 10 member 2",TRUE
+"204928_s_at",0.999285337578942,0.997709164367016,0.00290370891606084,-5.93967937406475,0.00153615717164257,"SLC10A3","solute carrier family 10 member 3",TRUE
+"239913_at",0.0941413026938497,0.000387412768287447,4.17625338577552,0.17987618163794,4.94681096731381,"SLC10A4","solute carrier family 10 member 4",TRUE
+"1555108_at",0.695739345331756,0.165193846774964,1.43521096947004,-4.98332047380855,1.01055944073574,"SLC10A7","solute carrier family 10 member 7",TRUE
+"224126_at",0.825648186672984,0.393120842392632,-0.870949498115454,-5.57682340154678,-0.86079332592462,"SLC10A7","solute carrier family 10 member 7",TRUE
+"235143_at",0.932749164656875,0.703037824883582,-0.386192295471451,-5.86730062935163,-0.188999512888652,"SLC10A7","solute carrier family 10 member 7",TRUE
+"1555116_s_at",0.591331966259927,0.0688545106532375,1.91228807278013,-4.30008830343874,1.16325098310214,"SLC11A1","solute carrier family 11 member 1",TRUE
+"230382_at",0.646692716816097,0.117621134490961,1.62819517022213,-4.7248962180585,0.456383891309567,"SLC11A1","solute carrier family 11 member 1",TRUE
+"210422_x_at",0.726696341943087,0.206642227206206,-1.30095274296838,-5.14733638970069,-0.550588149578279,"SLC11A1","solute carrier family 11 member 1",TRUE
+"217507_at",0.752312913127213,0.245636499558041,1.19261425240789,-5.26969192928055,0.92362558543181,"SLC11A1","solute carrier family 11 member 1",TRUE
+"210423_s_at",0.918141489589102,0.652363212302299,0.456656468780738,-5.83862096281538,0.218076851421229,"SLC11A1","solute carrier family 11 member 1",TRUE
+"217473_x_at",0.933400538871064,0.705368171320113,0.383001958449422,-5.86848741211642,0.12426038911121,"SLC11A1","solute carrier family 11 member 1",TRUE
+"203125_x_at",0.757950630724418,0.254422146285346,-1.17002698575547,-5.29403993377534,-0.351812997596438,"SLC11A2","solute carrier family 11 member 2",TRUE
+"237106_at",0.839051873022286,0.424874076936351,0.812989814121734,-5.62278558232114,0.385356963161301,"SLC11A2","solute carrier family 11 member 2",TRUE
+"203123_s_at",0.858826390511142,0.475152077750338,-0.726476740969555,-5.68584519577081,-0.292610777615478,"SLC11A2","solute carrier family 11 member 2",TRUE
+"203124_s_at",0.863865128741987,0.489973873020901,-0.70202388890015,-5.70244975321342,-0.278875015509664,"SLC11A2","solute carrier family 11 member 2",TRUE
+"210047_at",0.871225851789576,0.511968846210342,-0.666506005181787,-5.72560105225789,-0.489471045609982,"SLC11A2","solute carrier family 11 member 2",TRUE
+"1554842_at",0.773234064853267,0.284460104650256,1.09690909114131,-5.37004400335706,0.417547992891487,"SLC12A1","solute carrier family 12 member 1",TRUE
+"220281_at",0.896229101808264,0.579444600920062,-0.562467344150404,-5.78675529583779,-0.577800556197837,"SLC12A1","solute carrier family 12 member 1",TRUE
+"225835_at",0.879447209955825,0.533821724668361,-0.632050967273554,-5.74695836586815,-0.342936643810063,"SLC12A2","solute carrier family 12 member 2",TRUE
+"204404_at",0.941158863404109,0.736247326855348,-0.34109247506508,-5.88317489924113,-0.171176424982821,"SLC12A2","solute carrier family 12 member 2",TRUE
+"208354_s_at",0.886152779003734,0.548952805209995,0.608639941996804,-5.76084753041658,0.418017420537657,"SLC12A3","solute carrier family 12 member 3",TRUE
+"231634_at",0.893600768892136,0.568834891243378,0.578388481419332,-5.77804517468535,0.389822977583572,"SLC12A3","solute carrier family 12 member 3",TRUE
+"215274_at",0.976371465776674,0.886534181715685,0.144343417791325,-5.92954060182396,0.0469750002808356,"SLC12A3","solute carrier family 12 member 3",TRUE
+"209402_s_at",0.883016663633454,0.540662987626102,0.621422763850719,-5.75332639783835,0.480069900948335,"SLC12A4","solute carrier family 12 member 4",TRUE
+"209401_s_at",0.929234395612144,0.688937411208725,0.405585072095973,-5.8598780211368,0.185043207883432,"SLC12A4","solute carrier family 12 member 4",TRUE
+"228644_s_at",0.954618087644887,0.793179484599999,-0.265367830609153,-5.90544253852153,-0.102731179888687,"SLC12A4","solute carrier family 12 member 4",TRUE
+"211112_at",0.979976490833035,0.904412693247672,0.121471275379436,-5.93249928682593,0.0778202070758622,"SLC12A4","solute carrier family 12 member 4",TRUE
+"209400_at",0.986455005400648,0.937225044164698,0.0796571358752209,-5.93659341140091,0.0615289667941514,"SLC12A4","solute carrier family 12 member 4",TRUE
+"210040_at",0.89316156038085,0.567091036002469,-0.581019741373195,-5.77658299586834,-0.254535345531568,"SLC12A5","solute carrier family 12 member 5",TRUE
+"226741_at",0.354936527686974,0.00952282306406076,2.83831614182084,-2.63150071973185,1.06594820197923,"SLC12A6","solute carrier family 12 member 6",TRUE
+"220740_s_at",0.499428826990278,0.0315271804730588,2.29560802965839,-3.65480611764549,1.12344282814321,"SLC12A6","solute carrier family 12 member 6",TRUE
+"223596_at",0.538508613666048,0.0440262186207084,2.13541272011197,-3.93358586621948,1.39678963769495,"SLC12A6","solute carrier family 12 member 6",TRUE
+"218066_at",0.971242929121865,0.863525207735517,0.173897308521254,-5.92496528257606,0.0828585589003943,"SLC12A7","solute carrier family 12 member 7",TRUE
+"219874_at",0.675352428480841,0.141556564030487,1.52439904396678,-4.86710740440987,0.643264338652575,"SLC12A8","solute carrier family 12 member 8",TRUE
+"220371_s_at",0.737164479746093,0.223367241626951,-1.25272329408659,-5.20293355549417,-0.420715236438419,"SLC12A9","solute carrier family 12 member 9",TRUE
+"223995_at",0.929234395612144,0.68891474806039,0.405616367202615,-5.85986575356225,0.164729300173069,"SLC12A9","solute carrier family 12 member 9",TRUE
+"223994_s_at",0.942541563021456,0.742586563671005,-0.332567772670425,-5.88595676281031,-0.126020632847515,"SLC12A9","solute carrier family 12 member 9",TRUE
+"220503_at",0.941190903571492,0.736891797150157,-0.340224655210318,-5.88346127807242,-0.31138358781282,"SLC13A1","solute carrier family 13 member 1",TRUE
+"220502_s_at",0.990810941805126,0.955922637283413,0.055899823741328,-5.93816162520871,0.0500893338409374,"SLC13A1","solute carrier family 13 member 1",TRUE
+"239805_at",0.766550448794594,0.267819064993805,-1.13667437750974,-5.32924561081425,-0.832698846719881,"SLC13A2","solute carrier family 13 member 2",TRUE
+"207567_at",0.863559206655094,0.488583128884108,-0.704299947118196,-5.70092706449406,-0.553379585973846,"SLC13A2","solute carrier family 13 member 2",TRUE
+"231217_at",0.460687961482278,0.0230947520339603,2.44090900908574,-3.39187336850693,1.62482012509882,"SLC13A3","solute carrier family 13 member 3",TRUE
+"205244_s_at",0.790817398514927,0.320668863776758,-1.01584388307495,-5.44918726188333,-0.612559110955061,"SLC13A3","solute carrier family 13 member 3",TRUE
+"231208_at",0.816800680706682,0.36894853977761,0.917133065616103,-5.53809802537547,0.720434824642997,"SLC13A3","solute carrier family 13 member 3",TRUE
+"230686_s_at",0.839026687117702,0.424728225224975,-0.813249665148279,-5.62258612738444,-0.425904118567844,"SLC13A3","solute carrier family 13 member 3",TRUE
+"205243_at",0.912332517487259,0.632850901842191,-0.48440723190563,-5.82603569618816,-0.300823178805986,"SLC13A3","solute carrier family 13 member 3",TRUE
+"230687_at",0.988164716416515,0.943577993970977,0.0715804586820731,-5.93718819326678,0.0660973967257288,"SLC13A3","solute carrier family 13 member 3",TRUE
+"219824_at",0.97928472590149,0.899470253319157,-0.127787018586424,-5.93173310102001,-0.0838994963978621,"SLC13A4","solute carrier family 13 member 4",TRUE
+"228844_at",0.925511384407886,0.678096737787726,0.420602572371881,-5.85388423508406,0.198506449615317,"SLC13A5","solute carrier family 13 member 5",TRUE
+"205856_at",0.948703051410075,0.766822751732335,-0.300200480035423,-5.89588426501637,-0.286163873862486,"SLC14A1","solute carrier family 14 member 1 (Kidd blood group)",TRUE
+"229151_at",0.9850141508341,0.926012388712807,0.0939256928424902,-5.93538750569194,0.11397624770871,"SLC14A1","solute carrier family 14 member 1 (Kidd blood group)",TRUE
+"237612_at",0.908778331633763,0.620994371251377,-0.501458800562483,-5.81794276607444,-0.259672812299221,"SLC14A2-AS1","SLC14A2 antisense RNA 1",TRUE
+"211349_at",0.839519981963042,0.426365190923064,0.810336417291027,-5.62481883814343,0.38799393504672,"SLC15A1","solute carrier family 15 member 1",TRUE
+"207254_at",0.91994485246627,0.659175157270607,0.447054606540945,-5.84280614517643,0.304133256986415,"SLC15A1","solute carrier family 15 member 1",TRUE
+"240159_at",0.819723837900625,0.377066546408386,0.901406775513704,-5.55149242023875,0.817015128537323,"SLC15A2","solute carrier family 15 member 2",TRUE
+"205316_at",0.914242258486146,0.639241372371448,0.475277096226232,-5.83025649018963,0.511821741057243,"SLC15A2","solute carrier family 15 member 2",TRUE
+"205317_s_at",0.951383212308888,0.777602432403467,0.285910854744175,-5.89994673999878,0.168610727222978,"SLC15A2","solute carrier family 15 member 2",TRUE
+"219593_at",0.940044918888428,0.731493947855975,-0.347501506316166,-5.881037599092,-0.515635307360517,"SLC15A3","solute carrier family 15 member 3",TRUE
+"225043_at",0.614024511254138,0.0849637193789758,1.80326635833213,-4.46899022570753,0.838601296320245,"SLC15A4","solute carrier family 15 member 4",TRUE
+"225057_at",0.82847108093969,0.398428320159444,0.861058678034656,-5.58487556874897,0.84514368390268,"SLC15A4","solute carrier family 15 member 4",TRUE
+"229503_at",0.979612118310508,0.903088600115644,0.123162773106072,-5.93229788635629,0.104103037126368,"SLC15A4","solute carrier family 15 member 4",TRUE
+"202234_s_at",0.448873991611994,0.0214113099245374,2.47573051651767,-3.32754843209789,2.18136123787433,"SLC16A1","solute carrier family 16 member 1",TRUE
+"1557918_s_at",0.465776708318531,0.0241284199537088,2.42067748996237,-3.42902054970629,2.1705635187659,"SLC16A1","solute carrier family 16 member 1",TRUE
+"202236_s_at",0.475296051772729,0.026243688572366,2.38166245336826,-3.50017609669414,2.27115188022943,"SLC16A1","solute carrier family 16 member 1",TRUE
+"202235_at",0.498206796273596,0.0310645994423432,2.30259032647494,-3.64238188919425,2.45041963136513,"SLC16A1","solute carrier family 16 member 1",TRUE
+"209900_s_at",0.54295328972902,0.0457251041014196,2.11693077880943,-3.96494361392485,2.33277356210294,"SLC16A1","solute carrier family 16 member 1",TRUE
+"1568813_at",0.510292695849786,0.0339728470579464,2.26018192894264,-3.71750104608871,2.70348084543094,"SLC16A1-AS1","SLC16A1 antisense RNA 1",TRUE
+"1560579_s_at",0.51470556386048,0.0353134266594323,2.241740618327,-3.74990810153558,1.76118790569346,"SLC16A1-AS1","SLC16A1 antisense RNA 1",TRUE
+"1568799_at",0.581336273502073,0.0637226162903658,1.95173905694307,-4.23726526831819,0.956144872721389,"SLC16A1-AS1","SLC16A1 antisense RNA 1",TRUE
+"236220_at",0.728385463227073,0.209046671368111,-1.29383792432245,-5.1556504967755,-1.66030389440497,"SLC16A10","solute carrier family 16 member 10",TRUE
+"219915_s_at",0.810358506471539,0.354254386465891,0.946195598234371,-5.51278401309194,0.72575685446332,"SLC16A10","solute carrier family 16 member 10",TRUE
+"222939_s_at",0.843718185056779,0.439042086566995,0.788007361278594,-5.64168173092736,0.682576887107737,"SLC16A10","solute carrier family 16 member 10",TRUE
+"241952_at",0.55074985379986,0.0490575368414616,2.08240471991174,-4.0230558902765,1.21658615075867,"SLC16A11","solute carrier family 16 member 11",TRUE
+"1552761_at",0.813375393746656,0.36320683374013,0.928395270319652,-5.52837460677753,0.45720627472592,"SLC16A11","solute carrier family 16 member 11",TRUE
+"236639_at",0.95388518141013,0.786983842114953,-0.273524178459275,-5.90330917434426,-0.120276949631943,"SLC16A12-AS1","SLC16A12 antisense RNA 1",TRUE
+"238029_s_at",0.663789119801086,0.131756018454649,-1.56499328032507,-4.81236405206548,-1.76636301525538,"SLC16A14","solute carrier family 16 member 14",TRUE
+"204462_s_at",0.954577684533304,0.792178417533836,0.266684440721727,-5.90510250827026,0.199115688813901,"SLC16A2","solute carrier family 16 member 2",TRUE
+"205234_at",0.990791479568553,0.953207546717612,0.0593472625977698,-5.93796814247311,0.0905271092331299,"SLC16A4","solute carrier family 16 member 4",TRUE
+"206599_at",0.673366993714442,0.13961548931408,1.53225099405179,-4.85660759503228,1.74036758250199,"SLC16A5","solute carrier family 16 member 5",TRUE
+"213590_at",0.728385463227073,0.209787048527776,1.29165989518178,-5.15818791909921,0.975534424342701,"SLC16A5","solute carrier family 16 member 5",TRUE
+"206600_s_at",0.732074070325545,0.215762190132214,1.27429623825289,-5.17828654134989,1.40006535203405,"SLC16A5","solute carrier family 16 member 5",TRUE
+"207038_at",0.628581041101275,0.0996818914414678,-1.71832466733947,-4.59558908940164,-1.91533042029527,"SLC16A6","solute carrier family 16 member 6",TRUE
+"230748_at",0.635368778245437,0.106333640057206,-1.68341515611088,-4.64629905873024,-1.85712636053008,"SLC16A6","solute carrier family 16 member 6",TRUE
+"207057_at",0.847288501166363,0.445951919489061,-0.776003194258533,-5.65056388868297,-1.11640317494701,"SLC16A7","solute carrier family 16 member 7",TRUE
+"241866_at",0.889389445320988,0.557217955811348,-0.595996132282144,-5.76813844550538,-0.629251911840042,"SLC16A7","solute carrier family 16 member 7",TRUE
+"210807_s_at",0.896428361916712,0.580797106737971,-0.5604483484725,-5.78784300510555,-0.510198715115933,"SLC16A7","solute carrier family 16 member 7",TRUE
+"230003_at",0.957105919915331,0.805700307861771,-0.248939956023039,-5.90954463656391,-0.369814007670417,"SLC16A7","solute carrier family 16 member 7",TRUE
+"241925_x_at",0.980267546812478,0.908103360695968,-0.116758434026032,-5.93304575763918,-0.208829204880526,"SLC16A7","solute carrier family 16 member 7",TRUE
+"220455_at",0.591673459344198,0.068987989086772,1.91129692549402,-4.30165521209279,0.837425006508338,"SLC16A8","solute carrier family 16 member 8",TRUE
+"227506_at",0.867717011547419,0.500624634926619,-0.684714470707362,-5.71387586400888,-0.572304890131709,"SLC16A9","solute carrier family 16 member 9",TRUE
+"1560885_x_at",0.787983178144695,0.314046753476562,-1.03016660718768,-5.43560153418032,-0.436124385395164,"SLC17A1","solute carrier family 17 member 1",TRUE
+"206872_at",0.937355407116319,0.722076543885233,0.360243342177132,-5.87667164885813,0.208159325718334,"SLC17A1","solute carrier family 17 member 1",TRUE
+"1560884_at",0.947778780715578,0.761641240439731,0.307091716280217,-5.89385493065675,0.320907101268726,"SLC17A1","solute carrier family 17 member 1",TRUE
+"207097_s_at",0.397229407433966,0.0137822439122493,2.67498197224829,-2.95060635052118,1.53557094780409,"SLC17A2","solute carrier family 17 member 2",TRUE
+"207298_at",0.807528762746328,0.348797862892725,0.95719416765712,-5.50301514193358,0.601421007704296,"SLC17A3","solute carrier family 17 member 3",TRUE
+"1565925_at",0.647518308302168,0.118479103550274,1.62418288265517,-4.7305287498027,1.37594795686605,"SLC17A4","solute carrier family 17 member 4",TRUE
+"207051_at",0.955515814503015,0.796236964326875,0.261349567350789,-5.90646996679997,0.144444992234646,"SLC17A4","solute carrier family 17 member 4",TRUE
+"223441_at",0.597654932724127,0.0744860469414864,1.87186260247438,-4.36353583722656,0.750306567022077,"SLC17A5","solute carrier family 17 member 5",TRUE
+"221041_s_at",0.687734660055697,0.156870752791988,1.46535850133932,-4.94467145337814,0.630382946046934,"SLC17A5","solute carrier family 17 member 5",TRUE
+"220551_at",0.822466887436572,0.387401823787831,0.881704545547934,-5.56797073254216,0.645164723926429,"SLC17A6","solute carrier family 17 member 6",TRUE
+"204230_s_at",0.756473210756188,0.251728826639197,1.17688861642525,-5.28668641968213,0.475950080353693,"SLC17A7","solute carrier family 17 member 7",TRUE
+"204229_at",0.96863865991453,0.852462466576126,-0.18816182086955,-5.92245377145284,-0.12019414473524,"SLC17A7","solute carrier family 17 member 7",TRUE
+"1553415_at",0.992342196993659,0.963896669556668,0.045778787646153,-5.93866279536295,0.0518442980319915,"SLC17A8","solute carrier family 17 member 8",TRUE
+"219559_at",0.791353982620776,0.321828973369744,1.01335608107147,-5.45152951825418,0.939685861482235,"SLC17A9","solute carrier family 17 member 9",TRUE
+"233328_x_at",0.795265846168267,0.327393293707913,1.00150972531423,-5.46261143296785,0.853716566640114,"SLC17A9","solute carrier family 17 member 9",TRUE
+"232922_s_at",0.812302873476553,0.358742618700937,0.937234240928,-5.52066689394695,0.568722768001105,"SLC17A9","solute carrier family 17 member 9",TRUE
+"207074_s_at",0.96287357728432,0.831655085755368,0.215102417937962,-5.91717262625331,0.112158366166186,"SLC18A1","solute carrier family 18 member A1",TRUE
+"1553328_a_at",0.802679132489125,0.340429505633325,-0.974291559078459,-5.4876244451356,-0.612641741770823,"SLC18A2","solute carrier family 18 member A2",TRUE
+"205857_at",0.919485127002411,0.658200350855147,-0.4484260213934,-5.8422137225312,-0.343925049305138,"SLC18A2","solute carrier family 18 member A2",TRUE
+"207150_at",0.93601609274026,0.714145611498124,-0.371021223525004,-5.87285746102791,-0.272944238049122,"SLC18A3","solute carrier family 18 member A3",TRUE
+"226301_at",0.683019114815084,0.151915212718311,1.48392863784161,-4.92054073918031,1.61776683920164,"SLC18B1","solute carrier family 18 member B1",TRUE
+"209776_s_at",0.877823095900289,0.528645728243674,0.640141030494471,-5.74204146258821,0.357994277202954,"SLC19A1","solute carrier family 19 member 1",TRUE
+"229639_s_at",0.88702716361338,0.551181725772309,-0.605220420617677,-5.76283393661714,-0.306740828103795,"SLC19A1","solute carrier family 19 member 1",TRUE
+"1555953_at",0.915569510513076,0.643949249706509,0.468577067974507,-5.83330386897907,0.470552643000803,"SLC19A1","solute carrier family 19 member 1",TRUE
+"211576_s_at",0.97928472590149,0.899440310150682,-0.127825297707411,-5.93172833904421,-0.0661900901659376,"SLC19A1","solute carrier family 19 member 1",TRUE
+"1555952_at",0.979882745102683,0.904001198824406,-0.121996910683005,-5.9324369991834,-0.103384984175341,"SLC19A1","solute carrier family 19 member 1",TRUE
+"209775_x_at",0.98416037322447,0.922394843361743,0.0985332848329148,-5.93495578433471,0.0992796698410903,"SLC19A1","solute carrier family 19 member 1",TRUE
+"209777_s_at",0.998982279127329,0.996666656537376,0.00422512854069871,-5.93967478584251,0.00242020853150393,"SLC19A1","solute carrier family 19 member 1",TRUE
+"209681_at",0.213110659005423,0.0025452448162879,-3.40123219108761,-1.47919163856097,-2.04092872504731,"SLC19A2","solute carrier family 19 member 2",TRUE
+"239345_at",0.628680114171121,0.0997238852016826,1.71809814052204,-4.59592065884749,1.55279148449817,"SLC19A3","solute carrier family 19 member 3",TRUE
+"220736_at",0.71454754703986,0.189735293770947,1.35289154551826,-5.08547876342089,1.50249639159827,"SLC19A3","solute carrier family 19 member 3",TRUE
+"213664_at",0.946941640414848,0.759142520279253,-0.310420341485581,-5.89285836927738,-0.321716279989411,"SLC1A1","solute carrier family 1 member 1",TRUE
+"206396_at",0.957620703212172,0.810003580864725,-0.243310231486142,-5.91089047121964,-0.249987891877224,"SLC1A1","solute carrier family 1 member 1",TRUE
+"225491_at",0.452969693655811,0.0218232756628807,-2.46698007335117,-3.34375867456825,-2.68919871820334,"SLC1A2","solute carrier family 1 member 2",TRUE
+"208389_s_at",0.868313695469383,0.50272901810864,-0.681319327501141,-5.7160850628129,-0.453461815454974,"SLC1A2","solute carrier family 1 member 2",TRUE
+"1558010_s_at",0.9832781796011,0.918415756107022,-0.103603894245498,-5.93445681058003,-0.100392665028232,"SLC1A2","solute carrier family 1 member 2",TRUE
+"217055_x_at",0.98428730171779,0.923657034267023,-0.0969254156117782,-5.93510878421238,-0.0320948060420099,"SLC1A2","solute carrier family 1 member 2",TRUE
+"217037_at",0.990810941805126,0.955410215591112,0.0565504077966088,-5.93812599791338,0.0368947416446517,"SLC1A2","solute carrier family 1 member 2",TRUE
+"1558009_at",0.998027428501276,0.9906346327346,-0.0118711825730618,-5.93961484162239,-0.0124634983875409,"SLC1A2","solute carrier family 1 member 2",TRUE
+"202800_at",0.485571841560871,0.0281616175859938,2.34872040942231,-3.55975217038689,3.57231757168315,"SLC1A3","solute carrier family 1 member 3",TRUE
+"1569054_at",0.498396792791655,0.0312099166649766,2.30038666990736,-3.64630542795943,2.81040134363541,"SLC1A3","solute carrier family 1 member 3",TRUE
+"244377_at",0.839519981963042,0.4268481319698,0.809478277728716,-5.62547508204956,0.308722951944907,"SLC1A4","solute carrier family 1 member 4",TRUE
+"209610_s_at",0.860085676417428,0.479218815093042,0.719723822337968,-5.690484785399,0.693131538035139,"SLC1A4","solute carrier family 1 member 4",TRUE
+"212810_s_at",0.892646108943641,0.565081380847849,0.584057206383914,-5.77488710362196,0.660084042497189,"SLC1A4","solute carrier family 1 member 4",TRUE
+"209611_s_at",0.894136768148992,0.570415187810638,0.576007567424628,-5.77936269931257,0.416305366132974,"SLC1A4","solute carrier family 1 member 4",TRUE
+"212811_x_at",0.911800742526249,0.630981122893885,0.487086487068693,-5.82478219483645,0.34785325548366,"SLC1A4","solute carrier family 1 member 4",TRUE
+"208916_at",0.843753336849204,0.439289883764235,-0.787574881779991,-5.64200396302604,-0.293141376460586,"SLC1A5","solute carrier family 1 member 5",TRUE
+"206882_at",0.043795211728206,5.08165164669856e-05,5.00680251937388,1.96512770444712,3.70062188295931,"SLC1A6","solute carrier family 1 member 6",TRUE
+"1554593_s_at",0.0883065246138892,0.000337559463087386,4.23246218079522,0.301341148161872,5.02972207503785,"SLC1A6","solute carrier family 1 member 6",TRUE
+"1554592_a_at",0.319095917986488,0.00699195859164217,2.97258133002842,-2.36330157530285,2.91976144458862,"SLC1A6","solute carrier family 1 member 6",TRUE
+"210923_at",0.728385463227073,0.209016304937187,1.29392738317294,-5.15554619882287,0.367821890056211,"SLC1A7","solute carrier family 1 member 7",TRUE
+"207355_at",0.866404833591081,0.497372629390458,-0.689977103223131,-5.71043076473724,-0.407626306283815,"SLC1A7","solute carrier family 1 member 7",TRUE
+"243623_at",0.969859842767097,0.855910639348419,-0.183711534984827,-5.92325849176773,-0.162772580949267,"SLC1A7","solute carrier family 1 member 7",TRUE
+"230494_at",0.806086691531913,0.346428819772042,0.962005731961282,-5.4987090535863,0.900508926154319,"SLC20A1","solute carrier family 20 member 1",TRUE
+"201920_at",0.968482638277755,0.852264721684424,-0.188417151734197,-5.92240701914294,-0.0777344392746073,"SLC20A1","solute carrier family 20 member 1",TRUE
+"231818_x_at",0.777463110382572,0.296407175355995,1.06938810408829,-5.39752271438971,0.405192277650265,"SLC20A2","solute carrier family 20 member 2",TRUE
+"229371_at",0.823518986434235,0.390527942932369,-0.87581296028809,-5.57283269275711,-0.637090888375666,"SLC20A2","solute carrier family 20 member 2",TRUE
+"202744_at",0.990810941805126,0.956710593909686,-0.0548994614260882,-5.9382156030226,-0.0265078350202579,"SLC20A2","solute carrier family 20 member 2",TRUE
+"207201_s_at",0.735677568529031,0.220770477202729,1.26002521290785,-5.19463147649978,0.741060754151375,"SLC22A1","solute carrier family 22 member 1",TRUE
+"220100_at",0.780237570670818,0.301722444300572,1.05739910892666,-5.40929797037919,0.49958726506949,"SLC22A11","solute carrier family 22 member 11",TRUE
+"237799_at",0.990810941805126,0.956068937252669,-0.0557140820029197,-5.9381717211747,-0.0405422518532879,"SLC22A12","solute carrier family 22 member 12",TRUE
+"207444_at",0.677013732819214,0.144202954420822,1.51383515639642,-4.88116587011906,0.450272946781296,"SLC22A13","solute carrier family 22 member 13",TRUE
+"207408_at",0.731965025847759,0.215665317553942,1.2745747736724,-5.17796596371039,0.321271199351368,"SLC22A14","solute carrier family 22 member 14",TRUE
+"228497_at",0.852094603401457,0.457683307783929,0.755878892763713,-5.66516544904043,0.570712035475837,"SLC22A15","solute carrier family 22 member 15",TRUE
+"232233_at",0.606941574497969,0.0808034333931544,-1.8295735162784,-4.4288809327937,-0.794569358072251,"SLC22A16","solute carrier family 22 member 16",TRUE
+"232232_s_at",0.868361060481977,0.502785755160038,-0.681227901173311,-5.71614440820145,-0.410143848775342,"SLC22A16","solute carrier family 22 member 16",TRUE
+"218675_at",0.731054546207485,0.214077987346355,-1.2791525685455,-5.1726886322413,-1.63384083587301,"SLC22A17","solute carrier family 22 member 17",TRUE
+"221106_at",0.959079034903479,0.814484823934857,0.237456207299519,-5.91225746217741,0.111998609573131,"SLC22A17","solute carrier family 22 member 17",TRUE
+"204981_at",0.69805586360447,0.169050233912164,-1.42165572303965,-5.00048432364389,-1.58097826598595,"SLC22A18","solute carrier family 22 member 18",TRUE
+"206097_at",0.996366493108774,0.982261551807152,0.0224860091279799,-5.93943721459441,0.0155483889690329,"SLC22A18AS","solute carrier family 22 member 18 antisense",TRUE
+"207429_at",0.780655891246127,0.302239178611812,1.05624162439483,-5.41042851847551,0.545085449743525,"SLC22A2","solute carrier family 22 member 2",TRUE
+"223194_s_at",0.899808883319249,0.593404246784992,-0.541739959588285,-5.79774126723383,-0.359539754096481,"SLC22A23","solute carrier family 22 member 23",TRUE
+"233206_at",0.90415231543826,0.606403735167324,0.522651933845285,-5.80750357563694,0.277537989235321,"SLC22A23","solute carrier family 22 member 23",TRUE
+"1568718_at",0.931370027472813,0.696633608125351,0.39498109917031,-5.86398108157614,0.164562271471178,"SLC22A23","solute carrier family 22 member 23",TRUE
+"1568719_s_at",0.972819824894874,0.868500800965132,-0.167493883101594,-5.92602854428174,-0.121652878051568,"SLC22A23","solute carrier family 22 member 23",TRUE
+"1553923_at",0.922168942129244,0.667848297895867,0.434890616168144,-5.84798279027658,0.167663761358163,"SLC22A24","solute carrier family 22 member 24",TRUE
+"1561093_at",0.717276855910507,0.19301793812391,1.3425313942458,-5.09797986104943,0.363302205075399,"SLC22A25","solute carrier family 22 member 25",TRUE
+"1561094_a_at",0.723649742218726,0.20014078791067,-1.32051807190109,-5.12427419043699,-1.1721795391481,"SLC22A25","solute carrier family 22 member 25",TRUE
+"205421_at",0.905462783815257,0.611716010093666,0.514908191079573,-5.81136677764051,0.828941530077851,"SLC22A3","solute carrier family 22 member 3",TRUE
+"242578_x_at",0.927151504869754,0.68165772643355,0.415658876349651,-5.8558810267672,0.208632982842954,"SLC22A3","solute carrier family 22 member 3",TRUE
+"232765_x_at",0.994801700009981,0.975715335431829,0.0307866415824575,-5.9392218444324,0.0164554089073432,"SLC22A31","solute carrier family 22 member 31",TRUE
+"205896_at",0.990810941805126,0.953702781495777,-0.0587183931792864,-5.93800429980462,-0.0359972037584289,"SLC22A4","solute carrier family 22 member 4",TRUE
+"239615_at",0.308861881799719,0.00643408083683298,-3.00841821191493,-2.29091041019657,-1.71149738357192,"SLC22A5","solute carrier family 22 member 5",TRUE
+"205074_at",0.629618998226163,0.100561753611251,-1.71359533147584,-4.60250468305668,-0.963843190495526,"SLC22A5","solute carrier family 22 member 5",TRUE
+"210343_s_at",0.768285407497397,0.271448990023336,1.12784966862917,-5.3384105523453,0.85971328157876,"SLC22A6","solute carrier family 22 member 6",TRUE
+"216599_x_at",0.937113154905832,0.71990297970797,0.36319276892452,-5.87563890703901,0.176277767299425,"SLC22A6","solute carrier family 22 member 6",TRUE
+"221661_at",0.43607430599822,0.019885593340425,2.50956346969515,-3.26458872194063,1.65962630643282,"SLC22A7","solute carrier family 22 member 7",TRUE
+"221662_s_at",0.835223580564215,0.414237912407807,-0.832088069310291,-5.60796720606066,-0.354824831737891,"SLC22A7","solute carrier family 22 member 7",TRUE
+"231398_at",0.879765425648222,0.534585216942129,0.630861230302682,-5.7476763793125,0.47077962696822,"SLC22A7","solute carrier family 22 member 7",TRUE
+"220554_at",0.953553103224247,0.785719097512094,0.275191484404959,-5.90286518273272,0.15868691376908,"SLC22A7","solute carrier family 22 member 7",TRUE
+"1555553_a_at",0.990810941805126,0.956587251165032,0.0550560492663045,-5.93820721813927,0.0292545754465117,"SLC22A7","solute carrier family 22 member 7",TRUE
+"221298_s_at",0.887462893068143,0.552020585831815,-0.603935359107107,-5.76357763865472,-0.247934067938854,"SLC22A8","solute carrier family 22 member 8",TRUE
+"231352_at",0.932015431734097,0.699263009147954,0.391368857598818,-5.86535434075641,0.137592017092894,"SLC22A8","solute carrier family 22 member 8",TRUE
+"231625_at",0.822509813217163,0.387523599240496,-0.881474465480395,-5.56816117077878,-0.390053744962094,"SLC22A9","solute carrier family 22 member 9",TRUE
+"223732_at",0.707592026009871,0.178958985563137,-1.38792780213352,-5.04260906451075,-1.19518844058708,"SLC23A1","solute carrier family 23 member 1",TRUE
+"1554692_at",0.540483367247649,0.0447435095217497,2.12753237317009,-3.94697733046435,0.805019105921642,"SLC23A2","solute carrier family 23 member 2",TRUE
+"209237_s_at",0.803111243433434,0.340875211770399,0.973373745830496,-5.4884569582773,0.644421491482488,"SLC23A2","solute carrier family 23 member 2",TRUE
+"211572_s_at",0.880203017022901,0.535621967888511,0.629247145008147,-5.74864840835135,0.286186895698048,"SLC23A2","solute carrier family 23 member 2",TRUE
+"209236_at",0.90179361906738,0.599744299524976,0.532405429968533,-5.80255784995201,0.350492732929981,"SLC23A2","solute carrier family 23 member 2",TRUE
+"230949_at",0.85334340854827,0.460793356550775,0.750596052479649,-5.66893837862202,0.192687239826901,"SLC23A3","solute carrier family 23 member 3",TRUE
+"1553265_at",0.862634144901168,0.485946576429904,-0.708625139283782,-5.69802055651284,-0.555242713533224,"SLC23A3","solute carrier family 23 member 3",TRUE
+"219418_at",0.900535738777606,0.595531242926052,-0.538602969963598,-5.79936902433654,-0.144961820396549,"SLC23A3///NHEJ1","solute carrier family 23 member 3///non-homologous end joining factor 1",TRUE
+"210420_at",0.597654932724127,0.0746908706637768,1.87044332295035,-4.36574607446345,0.663404132018809,"SLC24A1","solute carrier family 24 member 1",TRUE
+"206081_at",0.717937808890208,0.193630210144219,-1.34061438396297,-5.10028419449635,-1.09072427302904,"SLC24A1","solute carrier family 24 member 1",TRUE
+"210421_s_at",0.851319596585235,0.454522118573342,-0.761270720259057,-5.66128886870524,-0.655964767383328,"SLC24A1","solute carrier family 24 member 1",TRUE
+"211842_s_at",0.903021267024792,0.602962980147726,0.52768483983596,-5.80496264513516,0.186911621351859,"SLC24A1","solute carrier family 24 member 1",TRUE
+"229110_at",0.943464796017993,0.746646637302048,0.327121193727529,-5.88769767134433,0.184636671394995,"SLC24A2","solute carrier family 24 member 2",TRUE
+"220867_s_at",0.968313447379469,0.85123031613803,-0.189752999420765,-5.92216138903648,-0.0964055764670633,"SLC24A2","solute carrier family 24 member 2",TRUE
+"57588_at",0.323645710780045,0.00735230084389407,-2.95086414131687,-2.40701170450692,-3.18466141486979,"SLC24A3","solute carrier family 24 member 3",TRUE
+"219090_at",0.327864702134751,0.0077460492102232,-2.92826968120571,-2.45235663274779,-4.76796035822679,"SLC24A3","solute carrier family 24 member 3",TRUE
+"243969_at",0.624494535652256,0.0960128224360835,-1.73843837517802,-4.56601874758522,-0.845621728011507,"SLC24A4","solute carrier family 24 member 4",TRUE
+"1568922_at",0.874480604680453,0.520865758976198,0.652382718516858,-5.73448709175697,0.277011076151767,"SLC24A4","solute carrier family 24 member 4",TRUE
+"1568870_at",0.97928472590149,0.899408025941345,-0.127866569816549,-5.93172320314115,-0.0693567057416464,"SLC24A4","solute carrier family 24 member 4",TRUE
+"210010_s_at",0.330451674411494,0.00800339419115289,-2.91408895004133,-2.48074648376672,-1.08230547418596,"SLC25A1","solute carrier family 25 member 1",TRUE
+"218275_at",0.701474435557404,0.173126584973235,-1.40759416787025,-5.0181479167022,-0.591652524385061,"SLC25A10","solute carrier family 25 member 10",TRUE
+"209003_at",0.959357995170594,0.816117614026739,0.235325347111037,-5.91274682657464,0.0650133267822177,"SLC25A11","solute carrier family 25 member 11",TRUE
+"207088_s_at",0.969882914559333,0.856837207023934,0.182516337562203,-5.9234713423801,0.056245398501666,"SLC25A11","solute carrier family 25 member 11",TRUE
+"203339_at",0.798535466562538,0.333046000488194,0.989617385073329,-5.47361738433358,0.393745879100918,"SLC25A12","solute carrier family 25 member 12",TRUE
+"203340_s_at",0.95396321837061,0.787680913568716,-0.272605571697461,-5.90355264821547,-0.0957570156188758,"SLC25A12","solute carrier family 25 member 12",TRUE
+"229081_at",0.451974019443452,0.0216971872291197,2.4696418566526,-3.33883093400606,0.650535598725313,"SLC25A13","solute carrier family 25 member 13",TRUE
+"203775_at",0.783844746433788,0.306751000483214,1.0461943743235,-5.42019522897812,0.353649739228288,"SLC25A13","solute carrier family 25 member 13",TRUE
+"229061_s_at",0.962377536390494,0.828679505908117,0.218967949690034,-5.91635722846131,0.0963720300349102,"SLC25A13","solute carrier family 25 member 13",TRUE
+"211855_s_at",0.429960090499345,0.0190488023451131,-2.52916139637004,-3.22791582636455,-1.00946751019746,"SLC25A14","solute carrier family 25 member 14",TRUE
+"204587_at",0.717994416213789,0.193952110455525,-1.33960842848042,-5.10149229351262,-0.451884107622201,"SLC25A14","solute carrier family 25 member 14",TRUE
+"218653_at",0.910863389772771,0.628133392738776,-0.491174040074187,-5.8228567979862,-0.19851010600617,"SLC25A15","solute carrier family 25 member 15",TRUE
+"222705_s_at",0.913140067375992,0.635336348874118,-0.480851324699402,-5.82768890365299,-0.178414667703606,"SLC25A15","solute carrier family 25 member 15",TRUE
+"214140_at",0.579752808738885,0.0624662639766032,-1.96182288995409,-4.22106640291505,-0.767282154210644,"SLC25A16","solute carrier family 25 member 16",TRUE
+"209910_at",0.782921408555092,0.305365400303008,1.04926871072483,-5.4172156389891,0.343188387708326,"SLC25A16","solute carrier family 25 member 16",TRUE
+"210686_x_at",0.8920930097751,0.563671945982049,0.586190789065638,-5.77369075577276,0.19257736119433,"SLC25A16","solute carrier family 25 member 16",TRUE
+"214210_at",0.767945391174396,0.270564146695467,1.12999279964426,-5.33619059268361,0.690708921038617,"SLC25A17","solute carrier family 25 member 17",TRUE
+"211754_s_at",0.978197434639598,0.894323825611881,-0.134369095774895,-5.93089335400232,-0.0406318786211184,"SLC25A17","solute carrier family 25 member 17",TRUE
+"223605_at",0.89961817630669,0.590698031577978,0.545739177096838,-5.79565278468945,0.563199081841961,"SLC25A18","solute carrier family 25 member 18",TRUE
+"223222_at",0.869971289491322,0.508107798649922,0.672677649995721,-5.72166075426403,0.315621059772642,"SLC25A19","solute carrier family 25 member 19",TRUE
+"224166_at",0.61760967235709,0.0878438724479886,-1.78569888838557,-4.49554011447621,-0.59963788309595,"SLC25A2","solute carrier family 25 member 2",TRUE
+"203658_at",0.597654932724127,0.0750473484834149,-1.86798127072617,-4.36957740819498,-0.640297077645334,"SLC25A20","solute carrier family 25 member 20",TRUE
+"220474_at",0.9116561917482,0.630208377364188,-0.488194830011386,-5.82426167579009,-0.53186033406676,"SLC25A21","solute carrier family 25 member 21",TRUE
+"230307_at",0.76912869907427,0.27503122162183,-1.11922519833393,-5.34730652189842,-1.11360213720308,"SLC25A21-AS1","SLC25A21 antisense RNA 1",TRUE
+"218725_at",0.79943091106207,0.334086908694065,0.987442726391696,-5.47561703130701,0.378589297857483,"SLC25A22","solute carrier family 25 member 22",TRUE
+"220182_at",0.929088231432081,0.68774676771229,-0.407229767744949,-5.85923204407797,-0.132137088182681,"SLC25A23","solute carrier family 25 member 23",TRUE
+"226010_at",0.957614082759983,0.80993046235153,-0.24340582061085,-5.91086787523499,-0.0716131684923322,"SLC25A23","solute carrier family 25 member 23",TRUE
+"1569121_at",0.812302873476553,0.357018253116211,0.94066818694914,-5.51765434987988,0.442373958103955,"SLC25A24","solute carrier family 25 member 24",TRUE
+"204342_at",0.966064677476069,0.841866310922781,-0.201862231476659,-5.9198559228838,-0.1003761497736,"SLC25A24","solute carrier family 25 member 24",TRUE
+"225212_at",0.853768202875953,0.462452657904012,-0.747786222832268,-5.67093491075662,-0.273239082603395,"SLC25A25","solute carrier family 25 member 25",TRUE
+"1560089_at",0.905306717560218,0.611038569695925,0.515893919057633,-5.81087813851508,0.153744960812224,"SLC25A25-AS1","SLC25A25 antisense RNA 1",TRUE
+"225862_at",0.940668681806864,0.73441647987041,-0.343559286185281,-5.88235691694941,-0.135047469054202,"SLC25A26","solute carrier family 25 member 26",TRUE
+"1552774_a_at",0.755868740464627,0.250320488634851,1.18049836781101,-5.28280281593238,1.25825291416149,"SLC25A27","solute carrier family 25 member 27",TRUE
+"230624_at",0.806649582904638,0.347735376495866,0.959349338181644,-5.50108882314178,1.05667758917477,"SLC25A27","solute carrier family 25 member 27",TRUE
+"1554161_at",0.864894115958506,0.493845472621986,0.695707200231102,-5.70665100651872,0.582168614652772,"SLC25A27","solute carrier family 25 member 27",TRUE
+"231787_at",0.911274533678096,0.629308741344174,-0.489485952790575,-5.82365385870556,-0.412646946714706,"SLC25A27","solute carrier family 25 member 27",TRUE
+"229361_at",0.948015976270656,0.763860558029972,-0.304138259673158,-5.89473025538618,-0.234353666924306,"SLC25A27","solute carrier family 25 member 27",TRUE
+"1560705_at",0.894729774938685,0.571956213754217,0.573689053120955,-5.78064063534586,0.409023831936014,"SLC25A28","solute carrier family 25 member 28",TRUE
+"223192_at",0.978255630670068,0.894866919787766,-0.133674218028051,-5.93098399460641,-0.0463570355358858,"SLC25A28","solute carrier family 25 member 28",TRUE
+"221432_s_at",0.999509719152342,0.998904263442914,-0.00138888026746478,-5.93968254121002,-0.000513633958481918,"SLC25A28","solute carrier family 25 member 28",TRUE
+"225305_at",0.457495355970503,0.0227175999512982,-2.44850044515854,-3.37789154641245,-1.51877232242263,"SLC25A29","solute carrier family 25 member 29",TRUE
+"225306_s_at",0.653593944884398,0.122968443303768,-1.6035766399555,-4.75928687282613,-1.22617586221225,"SLC25A29","solute carrier family 25 member 29",TRUE
+"232280_at",0.682238740660165,0.149761853962566,-1.49215186483811,-4.90977693500484,-0.923572323873517,"SLC25A29","solute carrier family 25 member 29",TRUE
+"231664_at",0.889452275006221,0.557589206445242,-0.595430511343847,-5.76846114996286,-0.454936756728011,"SLC25A29","solute carrier family 25 member 29",TRUE
+"228971_at",0.201150961341713,0.00224943873189067,-3.45279535419282,-1.37060093653426,-2.15665963209431,"SLC25A3","solute carrier family 25 member 3",TRUE
+"200030_s_at",0.908641534736832,0.619856567548485,-0.503103013755177,-5.81714794916371,-0.128024580165398,"SLC25A3","solute carrier family 25 member 3",TRUE
+"226782_at",0.858826390511142,0.475059248617229,-0.726631280389409,-5.68573853753159,-0.26452446258731,"SLC25A30","solute carrier family 25 member 30",TRUE
+"216712_at",0.861357981297227,0.48163947187999,0.715720136634866,-5.69321605524037,0.267667946818343,"SLC25A30","solute carrier family 25 member 30",TRUE
+"216721_at",0.904832003218088,0.609394659294824,-0.518288091805624,-5.80968752124528,-0.236105689922387,"SLC25A30","solute carrier family 25 member 30",TRUE
+"238171_at",0.989475734766121,0.948007941456439,-0.0659514651386909,-5.9375651750664,-0.0487041454167381,"SLC25A30","solute carrier family 25 member 30",TRUE
+"221037_s_at",0.863835356219448,0.489845222117664,-0.702234279681407,-5.70230919835045,-0.723719913614129,"SLC25A31","solute carrier family 25 member 31",TRUE
+"221020_s_at",0.9507311229803,0.775208855849744,-0.2890784453896,-5.89906315791836,-0.121909170315075,"SLC25A32","solute carrier family 25 member 32",TRUE
+"223296_at",0.588467901034655,0.0671212406642236,-1.92531415053663,-4.27944301739423,-0.588727098461852,"SLC25A33","solute carrier family 25 member 33",TRUE
+"232245_at",0.726696341943087,0.206675120660624,-1.30085497833583,-5.14745089577623,-0.713039689758902,"SLC25A34","solute carrier family 25 member 34",TRUE
+"1559977_a_at",0.885029460971826,0.546093633453442,0.613037113777216,-5.75827733742892,0.18294635588582,"SLC25A34","solute carrier family 25 member 34",TRUE
+"236064_at",0.534491752445599,0.0424269630656406,-2.15340814437545,-3.90288854001024,-0.943161675441247,"SLC25A35","solute carrier family 25 member 35",TRUE
+"228836_at",0.995459426584559,0.978781953612424,-0.026897916052025,-5.93933109774694,-0.0189426001320712,"SLC25A35","solute carrier family 25 member 35",TRUE
+"201919_at",0.547195868806649,0.0475636434112431,-2.09761326911254,-3.99753329824653,-0.631782569104654,"SLC25A36","solute carrier family 25 member 36",TRUE
+"201918_at",0.694505490882266,0.163829735954105,-1.44006675349315,-4.97713961296764,-0.526059545739344,"SLC25A36","solute carrier family 25 member 36",TRUE
+"201917_s_at",0.758189649141895,0.255147393444714,-1.16818855177638,-5.2960037665486,-0.435424489735261,"SLC25A36","solute carrier family 25 member 36",TRUE
+"223698_at",0.975242094553739,0.879783905132823,0.152998978592092,-5.92828839964829,0.0699561071774921,"SLC25A36","solute carrier family 25 member 36",TRUE
+"237741_at",0.986260660718739,0.932634167887145,-0.0854969907001964,-5.93612380518179,-0.0427400323116354,"SLC25A36","solute carrier family 25 member 36",TRUE
+"222529_at",0.481415880463719,0.0273308622397693,2.36272726139396,-3.53447774673158,1.41584884195779,"SLC25A37","solute carrier family 25 member 37",TRUE
+"218978_s_at",0.517859245504688,0.0369805321305436,2.21967776773756,-3.78846954152489,1.23196810285773,"SLC25A37","solute carrier family 25 member 37",TRUE
+"221920_s_at",0.55074985379986,0.0489841130076679,2.08314243699937,-4.02182063754188,1.15502542745931,"SLC25A37","solute carrier family 25 member 37",TRUE
+"218136_s_at",0.625586175410773,0.0968050104967926,1.73404074227434,-4.57250582096555,0.833544117555238,"SLC25A37","solute carrier family 25 member 37",TRUE
+"231078_at",0.627092759817312,0.0987812954655078,1.72320243878747,-4.58844153493294,1.51326752161142,"SLC25A37","solute carrier family 25 member 37",TRUE
+"226928_x_at",0.629618998226163,0.100510697891895,1.7138687951787,-4.60210519191037,0.667820168409477,"SLC25A37","solute carrier family 25 member 37",TRUE
+"226179_at",0.659870891937597,0.127648415627107,1.58275328606325,-4.78805797211673,0.713625558747426,"SLC25A37","solute carrier family 25 member 37",TRUE
+"242335_at",0.664067502715663,0.132060465606354,1.56369530388378,-4.81413200030722,0.685072911639656,"SLC25A37","solute carrier family 25 member 37",TRUE
+"222528_s_at",0.677013732819214,0.144507974300484,1.51262781265186,-4.8827676403098,1.24490544451509,"SLC25A37","solute carrier family 25 member 37",TRUE
+"228527_s_at",0.692289844352812,0.161798157017606,1.44735922212387,-4.96782514011284,1.26119270922488,"SLC25A37","solute carrier family 25 member 37",TRUE
+"217961_at",0.561683712684032,0.0548026235792947,-2.02753619605485,-4.11412756729758,-0.669865584234854,"SLC25A38","solute carrier family 25 member 38",TRUE
+"223649_s_at",0.958931830316768,0.814082053970229,-0.23798201163789,-5.91213603328983,-0.0801639695407488,"SLC25A39","solute carrier family 25 member 39",TRUE
+"1560944_at",0.869500163494326,0.506862537007612,-0.674673721963272,-5.72037891797107,-0.346997477241703,"SLC25A3P1","solute carrier family 25 member 3 pseudogene 1",TRUE
+"214821_at",0.695005304830231,0.164575988747971,1.43740632632176,-4.98052814611161,0.834245561826061,"SLC25A4","solute carrier family 25 member 4",TRUE
+"202825_at",0.906476756086155,0.61383807785104,-0.511823754713517,-5.8128898903448,-0.342755861570447,"SLC25A4","solute carrier family 25 member 4",TRUE
+"227012_at",0.9340157600858,0.707678491902785,-0.379843028099914,-5.86965294779674,-0.110207742383338,"SLC25A40","solute carrier family 25 member 40",TRUE
+"205716_at",0.983315178158355,0.918624100045221,0.103338330639141,-5.93448356397294,0.0349598387357446,"SLC25A40","solute carrier family 25 member 40",TRUE
+"1555509_a_at",0.911640104107437,0.630019594580695,0.488465693923927,-5.82413429222467,0.190501435882121,"SLC25A41","solute carrier family 25 member 41",TRUE
+"214029_at",0.78969417320323,0.317776931793426,1.02207300169851,-5.44329978876155,0.664373717113342,"SLC25A42","solute carrier family 25 member 42",TRUE
+"242274_x_at",0.904381089098038,0.607478835360436,0.521082153729379,-5.80829124822034,0.479986819495277,"SLC25A42","solute carrier family 25 member 42",TRUE
+"228921_at",0.952137205766777,0.780990814695053,0.281431860242625,-5.90117964495434,0.251480153111428,"SLC25A42","solute carrier family 25 member 42",TRUE
+"226737_at",0.963120895816356,0.832320337234862,0.214238660017556,-5.91735285166757,0.132323956408691,"SLC25A42","solute carrier family 25 member 42",TRUE
+"1557411_s_at",0.958723944343516,0.812810952405675,0.239641847979636,-5.91175095932526,0.209626233403418,"SLC25A43","solute carrier family 25 member 43",TRUE
+"212683_at",0.297610352921697,0.00543237553206866,-3.08099679537226,-2.14334379561117,-0.855993352303152,"SLC25A44","solute carrier family 25 member 44",TRUE
+"32091_at",0.317600554649094,0.00693580360770039,-2.9760619722206,-2.35628481523634,-0.934437657336334,"SLC25A44","solute carrier family 25 member 44",TRUE
+"236436_at",0.588984479037728,0.067672167660293,-1.92114203022216,-4.28606605575585,-0.91109379937356,"SLC25A45","solute carrier family 25 member 45",TRUE
+"1563498_s_at",0.90998880119877,0.625477125749958,-0.494994434059545,-5.82104303248783,-0.542486572442876,"SLC25A45","solute carrier family 25 member 45",TRUE
+"226831_at",0.651636743353835,0.121090560672798,-1.61211838146918,-4.74740048413578,-0.699469542310817,"SLC25A46","solute carrier family 25 member 46",TRUE
+"212833_at",0.92051722798026,0.662057021325073,-0.443005306901966,-5.84454497033724,-0.148230859704675,"SLC25A46","solute carrier family 25 member 46",TRUE
+"237765_at",0.774230543658252,0.28684296372315,1.09135445107898,-5.37564024659239,0.512758330533318,"SLC25A47","solute carrier family 25 member 47",TRUE
+"1554542_at",0.837609393049242,0.421748295330031,0.81857100252702,-5.61848846302092,0.457407432768542,"SLC25A48","solute carrier family 25 member 48",TRUE
+"231372_at",0.959357995170594,0.816245160436872,-0.235158940674102,-5.91278485807624,-0.192606721303497,"SLC25A48","solute carrier family 25 member 48",TRUE
+"200657_at",0.891444650197327,0.561149529507845,-0.590016063076434,-5.77153527488903,-0.128697856922885,"SLC25A5","solute carrier family 25 member 5",TRUE
+"239242_at",0.864894115958506,0.493936612364556,-0.695558844120926,-5.70674924328199,-0.216518046305366,"SLC25A5-AS1","SLC25A5 antisense RNA 1",TRUE
+"239125_at",0.904381089098038,0.607352565220562,0.521266455080884,-5.80819889043424,0.428884334968784,"SLC25A5-AS1","SLC25A5 antisense RNA 1",TRUE
+"238574_at",0.85334340854827,0.461292443898658,-0.749750273031731,-5.66954009559928,-0.29650574070317,"SLC25A51","solute carrier family 25 member 51",TRUE
+"232092_at",0.983212176432519,0.918189131336015,0.103892768007891,-5.93442763098857,0.0318358898467341,"SLC25A51","solute carrier family 25 member 51",TRUE
+"1561660_at",0.870933984399955,0.510852361768753,0.668287954367811,-5.72446693486654,0.562580145892678,"SLC25A53","solute carrier family 25 member 53",TRUE
+"1561578_s_at",0.901639484915293,0.598457842298864,0.534295601312514,-5.80158910326325,0.347745370325476,"SLC25A53","solute carrier family 25 member 53",TRUE
+"212826_s_at",0.643688366500038,0.114317796515152,-1.64387622570699,-4.70278039233856,-0.751525646553601,"SLC25A6","solute carrier family 25 member 6",TRUE
+"212085_at",0.700061364939874,0.171631827840959,-1.41271933195344,-5.01172660204558,-0.621820567393153,"SLC25A6","solute carrier family 25 member 6",TRUE
+"220733_at",0.648301983183996,0.119427481931947,1.61977602575036,-4.73670283213444,0.64256927789919,"SLC26A1","solute carrier family 26 member 1",TRUE
+"205058_at",0.766550448794594,0.267768429874386,1.13679809541921,-5.32911667502705,0.742893729735893,"SLC26A1","solute carrier family 26 member 1",TRUE
+"1552843_at",0.895690630367785,0.575862533850202,0.567826052309654,-5.7838499648128,0.197678910236643,"SLC26A1","solute carrier family 26 member 1",TRUE
+"214951_at",0.678772326285111,0.146358573414206,-1.50534708148229,-4.89240524684282,-0.663430028207022,"SLC26A10","solute carrier family 26 member 10",TRUE
+"226679_at",0.147189326785666,0.00102298937683682,-3.7787786345494,-0.676619557498667,-1.1487965849181,"SLC26A11","solute carrier family 26 member 11",TRUE
+"205097_at",0.78578093265889,0.311294284433316,1.03618224088665,-5.42984426808347,0.967242508815085,"SLC26A2","solute carrier family 26 member 2",TRUE
+"224959_at",0.855405088766616,0.468001511296529,0.738433255515003,-5.67752955310878,0.712539776733557,"SLC26A2","solute carrier family 26 member 2",TRUE
+"224963_at",0.870947480802804,0.510881116323848,0.668242033806486,-5.72449619730784,0.516720398054217,"SLC26A2","solute carrier family 26 member 2",TRUE
+"215657_at",0.509163975230892,0.0338353104975985,2.26211130977729,-3.71410139187011,1.86913475896633,"SLC26A3","solute carrier family 26 member 3",TRUE
+"206143_at",0.946215823740655,0.756167162695212,-0.314388587746772,-5.89165640299068,-0.412857327415976,"SLC26A3","solute carrier family 26 member 3",TRUE
+"206529_x_at",0.937113154905832,0.719824260544492,-0.363299648672482,-5.87560132698017,-0.225063018612649,"SLC26A4","solute carrier family 26 member 4",TRUE
+"1557107_at",0.990345207157428,0.95165568232122,0.0613180436650829,-5.93785233679683,0.0521459188580367,"SLC26A4-AS1","SLC26A4 antisense RNA 1",TRUE
+"232551_at",0.877074739399942,0.526276926849454,0.643857815417831,-5.73976235848207,0.394587371868307,"SLC26A6","solute carrier family 26 member 6",TRUE
+"1552826_at",0.689913893405055,0.159121948018318,1.45707924456288,-4.95535048835509,1.29510672316229,"SLC26A7","solute carrier family 26 member 7",TRUE
+"239006_at",0.99164669139131,0.960564557506906,0.05000741075671,-5.93846553534575,0.0607045519380178,"SLC26A7","solute carrier family 26 member 7",TRUE
+"1552827_s_at",0.994304286761558,0.97408313432307,0.0328566021177849,-5.93915768235617,0.0181822709903159,"SLC26A7","solute carrier family 26 member 7",TRUE
+"237340_at",0.953983577550391,0.788597024621804,0.271398676806992,-5.90387129585995,0.178868717025186,"SLC26A8","solute carrier family 26 member 8",TRUE
+"242271_at",0.83242103542195,0.408694333850586,0.842164957899723,-5.60001885787994,0.579027798135147,"SLC26A9","solute carrier family 26 member 9",TRUE
+"226728_at",0.75959865506602,0.257416539259478,-1.16246143329632,-5.30210418724442,-0.574857688984087,"SLC27A1","solute carrier family 27 member 1",TRUE
+"205768_s_at",0.75959865506602,0.25746006645456,1.16235194142759,-5.30222055995821,1.16259303765587,"SLC27A2","solute carrier family 27 member 2",TRUE
+"205769_at",0.805495973616765,0.344812679698224,0.965300999438065,-5.4957485815436,1.02651038431896,"SLC27A2","solute carrier family 27 member 2",TRUE
+"222217_s_at",0.974884920935236,0.876962212937741,-0.156620612054219,-5.92774287208816,-0.151892924112774,"SLC27A3","solute carrier family 27 member 3",TRUE
+"225779_at",0.54613142770476,0.0473603835030647,-2.09971559204681,-3.99399584089612,-0.772464186778818,"SLC27A4","solute carrier family 27 member 4",TRUE
+"234948_at",0.653206225743412,0.122422889402207,1.60604685620891,-4.7558544395989,0.624744870731692,"SLC27A5","solute carrier family 27 member 5",TRUE
+"219733_s_at",0.785435091542984,0.310898696866452,1.03704988932178,-5.4290113917571,0.819911152956434,"SLC27A5","solute carrier family 27 member 5",TRUE
+"219932_at",0.821424121108148,0.383349975089011,0.889387093505094,-5.56158540595219,1.61332396311998,"SLC27A6","solute carrier family 27 member 6",TRUE
+"231187_at",0.402463840838386,0.0147945550206299,2.64328956886682,-3.01151843594711,1.96724063511404,"SLC28A1","solute carrier family 28 member 1",TRUE
+"207560_at",0.694519360341564,0.164000176189459,1.43945826748705,-4.97791508069501,0.421746650888815,"SLC28A1","solute carrier family 28 member 1",TRUE
+"207249_s_at",0.858400984062047,0.474153634643183,0.728139852623323,-5.68469623629692,0.309793302925989,"SLC28A2","solute carrier family 28 member 2",TRUE
+"216432_at",0.929972194057784,0.690999898930023,0.402738742318895,-5.86098987657913,0.35401422529795,"SLC28A2","solute carrier family 28 member 2",TRUE
+"220475_at",0.515810181619652,0.0361378034810593,2.23071479443887,-3.7692077860855,0.642129760392561,"SLC28A3","solute carrier family 28 member 3",TRUE
+"232277_at",0.552420073963858,0.0502633696602511,2.070428702005,-4.0430691914236,1.94870382761198,"SLC28A3","solute carrier family 28 member 3",TRUE
+"201802_at",0.832792886465252,0.409911189008268,-0.839945612188116,-5.60177708627208,-0.381380625183541,"SLC29A1","solute carrier family 29 member 1 (Augustine blood group)",TRUE
+"201801_s_at",0.896159990898752,0.57920453326891,-0.562825959487543,-5.78656169942793,-0.397134330320375,"SLC29A1","solute carrier family 29 member 1 (Augustine blood group)",TRUE
+"1560151_x_at",0.657802943703404,0.126495475996298,1.58782348055995,-4.78107961526582,0.750472107244147,"SLC29A2","solute carrier family 29 member 2",TRUE
+"1560149_at",0.700327284509671,0.172062120033259,1.41124031751369,-5.01358162998521,0.460325518076653,"SLC29A2","solute carrier family 29 member 2",TRUE
+"1553540_a_at",0.711977799428804,0.185667263665805,1.36592812343527,-5.06963407883439,0.656297584776944,"SLC29A2","solute carrier family 29 member 2",TRUE
+"1560062_at",0.950544755871964,0.774815714847928,0.289599004929289,-5.89891702672995,0.131160725317367,"SLC29A2","solute carrier family 29 member 2",TRUE
+"204717_s_at",0.953553103224247,0.785808719900328,0.275073309518487,-5.90289674005635,0.18630952846784,"SLC29A2","solute carrier family 29 member 2",TRUE
+"219344_at",0.911046362974546,0.628909426204816,-0.490059304744022,-5.82338344096129,-0.406024628386948,"SLC29A3","solute carrier family 29 member 3",TRUE
+"1570124_at",0.897375964261386,0.583876616361316,-0.555860064449492,-5.79030077433998,-0.413688506856246,"SLC29A4","solute carrier family 29 member 4",TRUE
+"227281_at",0.925511384407886,0.678097305979436,-0.42060178270772,-5.85388455588817,-0.404655238364648,"SLC29A4","solute carrier family 29 member 4",TRUE
+"201249_at",0.726636642789909,0.206384114311623,1.30172031539501,-5.14643712293155,0.862043472383087,"SLC2A1","solute carrier family 2 member 1",TRUE
+"201250_s_at",0.853460708803218,0.4620821548833,0.748413103221529,-5.67049009385765,0.288021566343222,"SLC2A1","solute carrier family 2 member 1",TRUE
+"1558832_at",0.920780424288498,0.663101238313522,0.44153993920707,-5.84517039396946,0.207999954392588,"SLC2A1-AS1","SLC2A1 antisense RNA 1",TRUE
+"221024_s_at",0.861659105448003,0.48252766196442,-0.714254037121527,-5.69421258523757,-1.0385712467766,"SLC2A10","solute carrier family 2 member 10",TRUE
+"232167_at",0.856631989847095,0.470622055933737,-0.734039001586118,-5.68060069241258,-0.349977455732001,"SLC2A11","solute carrier family 2 member 11",TRUE
+"221262_s_at",0.887948692739633,0.553400895800937,-0.601823071255666,-5.76479676431956,-0.260232483381216,"SLC2A11","solute carrier family 2 member 11",TRUE
+"1558540_s_at",0.942684843065067,0.74291527951855,0.332126421485507,-5.88609889247679,0.224629848845486,"SLC2A11","solute carrier family 2 member 11",TRUE
+"235050_at",0.51531387545335,0.0355425939949999,2.23865222466859,-3.75531981683937,2.32890295062493,"SLC2A12","solute carrier family 2 member 12",TRUE
+"244353_s_at",0.527546822913581,0.0402176570144327,2.17930397229719,-3.85843238097365,1.52108027996297,"SLC2A12","solute carrier family 2 member 12",TRUE
+"234561_at",0.839519981963042,0.426264714685072,0.81051502997894,-5.62468216586295,0.590761939816359,"SLC2A13","solute carrier family 2 member 13",TRUE
+"1552694_at",0.910239198910083,0.626953781284953,0.49286970607146,-5.82205345995153,0.550570238368239,"SLC2A13","solute carrier family 2 member 13",TRUE
+"234268_at",0.961212424803935,0.824123536676731,0.224893182353158,-5.91507929666418,0.174978855634664,"SLC2A13","solute carrier family 2 member 13",TRUE
+"227176_at",0.974217904908367,0.874346092251551,-0.159980311051075,-5.92722541603573,-0.117186366889532,"SLC2A13","solute carrier family 2 member 13",TRUE
+"1552695_a_at",0.990810941805126,0.954171731040932,0.0581229241986815,-5.93803818183321,0.0437212002454368,"SLC2A13","solute carrier family 2 member 13",TRUE
+"216236_s_at",0.74371414757151,0.234510977222369,1.22210378957249,-5.23729477678945,0.836864474089141,"SLC2A14///SLC2A3","solute carrier family 2 member 14///solute carrier family 2 member 3",TRUE
+"222088_s_at",0.756952614607938,0.252567565261395,1.1747459691459,-5.28898670233234,1.02815886297085,"SLC2A14///SLC2A3","solute carrier family 2 member 14///solute carrier family 2 member 3",TRUE
+"206535_at",0.620223198657182,0.0900263459282829,1.77271457708503,-4.51504158466586,0.998911326778182,"SLC2A2","solute carrier family 2 member 2",TRUE
+"202497_x_at",0.62110896023334,0.091744871114386,1.76267962835386,-4.53004188128111,1.87782999863966,"SLC2A3","solute carrier family 2 member 3",TRUE
+"202499_s_at",0.629448148250054,0.100262714643068,1.71519872369605,-4.6001616778469,2.22469938633695,"SLC2A3","solute carrier family 2 member 3",TRUE
+"202498_s_at",0.747587302711183,0.239455524021267,1.20887035899248,-5.25191790379691,0.984281770027481,"SLC2A3","solute carrier family 2 member 3",TRUE
+"206603_at",0.769258076576208,0.276277684875742,1.1162434893884,-5.35036803393317,0.734174013325629,"SLC2A4","solute carrier family 2 member 4",TRUE
+"218494_s_at",0.581406183553129,0.0638690688515814,-1.95057503582154,-4.23913150439966,-0.732317279924599,"SLC2A4RG","SLC2A4 regulator",TRUE
+"1555500_s_at",0.594466058431828,0.0713033088467477,-1.89436669380497,-4.32833285781648,-0.788938599329452,"SLC2A4RG","SLC2A4 regulator",TRUE
+"222650_s_at",0.634072872504683,0.104942394573294,-1.69056010516265,-4.6359839844358,-0.684955244656472,"SLC2A4RG","SLC2A4 regulator",TRUE
+"227362_at",0.6708432030569,0.136794399337041,1.5438244006454,-4.84105335119496,0.791766979754859,"SLC2A4RG","SLC2A4 regulator",TRUE
+"204429_s_at",0.683838837468118,0.152705154416243,1.48093579486522,-4.92444633093403,0.418830459441367,"SLC2A5","solute carrier family 2 member 5",TRUE
+"230705_at",0.774230543658252,0.286726973785868,-1.09162406004301,-5.37536920243761,-0.650941653419072,"SLC2A5","solute carrier family 2 member 5",TRUE
+"242525_at",0.947778780715578,0.761990933616314,-0.306626161989214,-5.89399346492875,-0.120214818587572,"SLC2A5","solute carrier family 2 member 5",TRUE
+"204430_s_at",0.986421906591669,0.936697588535592,0.0803279410979324,-5.93654115647482,0.0427882284295298,"SLC2A5","solute carrier family 2 member 5",TRUE
+"220091_at",0.775341201891078,0.291806586904605,1.07988981024137,-5.38711066851628,1.22576563156722,"SLC2A6","solute carrier family 2 member 6",TRUE
+"218985_at",0.626123824677003,0.0970305837492135,-1.73279415578695,-4.57434247659287,-0.977951170561663,"SLC2A8","solute carrier family 2 member 8",TRUE
+"239426_at",0.933448396773721,0.705613575466994,0.382666226417443,-5.86861173761635,0.211575352232125,"SLC2A8","solute carrier family 2 member 8",TRUE
+"219991_at",0.774230543658252,0.288733052629598,1.08697213535254,-5.38003752445839,0.351575718030602,"SLC2A9","solute carrier family 2 member 9",TRUE
+"240223_at",0.798428326317339,0.332871045671453,0.989983359553017,-5.47328046939101,0.468273365475947,"SLC2A9","solute carrier family 2 member 9",TRUE
+"212907_at",0.851254064344218,0.454414133324714,-0.761455301296964,-5.66115569858403,-0.434399212077365,"SLC30A1","solute carrier family 30 member 1",TRUE
+"242716_at",0.907964244160782,0.617803319883719,0.506073677574896,-5.81570548551851,0.301482971584641,"SLC30A1","solute carrier family 30 member 1",TRUE
+"228181_at",0.954577684533304,0.792302367669641,-0.266521394594256,-5.9051447075509,-0.116941548489669,"SLC30A1","solute carrier family 30 member 1",TRUE
+"220435_at",0.904832003218088,0.609699770301214,0.517843500044707,-5.80990902198684,0.464960281896475,"SLC30A10","solute carrier family 30 member 10",TRUE
+"230084_at",0.987845126842439,0.941971532383309,-0.0736223142781933,-5.93704382396824,-0.0477751489486904,"SLC30A2","solute carrier family 30 member 2",TRUE
+"224485_s_at",0.990810941805126,0.956615243892418,-0.0550205114162167,-5.93820912319574,-0.0227218290510129,"SLC30A2","solute carrier family 30 member 2",TRUE
+"207035_at",0.990712448117538,0.952986552973858,-0.0596278974098586,-5.93795188290423,-0.0278502492301653,"SLC30A3","solute carrier family 30 member 3",TRUE
+"227193_at",0.789406360796076,0.316114363673891,1.02567210107783,-5.43988326472897,0.519937638415108,"SLC30A4","solute carrier family 30 member 4",TRUE
+"238845_at",0.789860910391852,0.318850369676692,1.01975624454655,-5.44549328025399,0.647490971707461,"SLC30A4","solute carrier family 30 member 4",TRUE
+"207362_at",0.940044918888428,0.731388843066671,0.347643387017426,-5.88098983939287,0.283846275991168,"SLC30A4","solute carrier family 30 member 4",TRUE
+"243166_at",0.73223722457785,0.21625863988821,-1.27287031658293,-5.17992675521541,-0.521336938146844,"SLC30A5","solute carrier family 30 member 5",TRUE
+"1555334_s_at",0.774360462422895,0.290427996217935,-1.08305981929754,-5.38394986896419,-0.425320387626778,"SLC30A5","solute carrier family 30 member 5",TRUE
+"218989_x_at",0.778686132916778,0.299401343255405,-1.06261584991613,-5.40418885244383,-0.37295467138258,"SLC30A5","solute carrier family 30 member 5",TRUE
+"220181_x_at",0.808233282592165,0.350341484448378,-0.954070978771759,-5.50579965199575,-0.294096441530431,"SLC30A5","solute carrier family 30 member 5",TRUE
+"232432_s_at",0.812302873476553,0.359117287016738,-0.936489585082966,-5.52131883337491,-0.33162492941968,"SLC30A5","solute carrier family 30 member 5",TRUE
+"226161_at",0.421158920993522,0.0174988270585348,2.56768766317237,-3.15539889444872,0.641453016673941,"SLC30A6","solute carrier family 30 member 6",TRUE
+"226162_at",0.592488489935347,0.0694422245605716,1.90793655087569,-4.30696343885326,0.828785718983506,"SLC30A6","solute carrier family 30 member 6",TRUE
+"243643_x_at",0.65284137151906,0.122103086852562,1.60749916782726,-4.75383449959357,0.431112823463563,"SLC30A6","solute carrier family 30 member 6",TRUE
+"220814_at",0.977281206457742,0.891394856260587,-0.138117828704501,-5.93039627325038,-0.129403839820558,"SLC30A6","solute carrier family 30 member 6",TRUE
+"226217_at",0.877275291808937,0.526798397451688,0.643038816312368,-5.74026565154191,0.256400315038961,"SLC30A7","solute carrier family 30 member 7",TRUE
+"239596_at",0.879419229950485,0.533680108674696,0.632271746024424,-5.74682498137721,0.422071756438879,"SLC30A7","solute carrier family 30 member 7",TRUE
+"226601_at",0.95570083379884,0.797125288042588,0.260182923266014,-5.9067653485467,0.102427336516755,"SLC30A7","solute carrier family 30 member 7",TRUE
+"1552985_at",0.937842878751575,0.724914444735901,-0.356397331659525,-5.87800583610943,-0.164507243699346,"SLC30A8","solute carrier family 30 member 8",TRUE
+"239983_at",0.9557369180672,0.798064362036726,0.258950029388121,-5.9070760771438,0.0920269970827787,"SLC30A8","solute carrier family 30 member 8",TRUE
+"229500_at",0.670759385801556,0.136299247878997,-1.54587598914328,-4.83828642025825,-0.721810634717954,"SLC30A9","solute carrier family 30 member 9",TRUE
+"202614_at",0.936456142259101,0.716377358961698,-0.367983877409779,-5.8739435795077,-0.106084314203008,"SLC30A9","solute carrier family 30 member 9",TRUE
+"203971_at",0.478691006415319,0.0267907382728121,-2.37204595248743,-3.51761586357584,-1.01946244690843,"SLC31A1","solute carrier family 31 member 1",TRUE
+"235013_at",0.572924743912668,0.0601328690732929,-1.98103669233809,-4.19004410060711,-0.664527380720342,"SLC31A1","solute carrier family 31 member 1",TRUE
+"236217_at",0.632216562924782,0.103342888621409,-1.69887458288997,-4.62393902916315,-0.598184793735077,"SLC31A1","solute carrier family 31 member 1",TRUE
+"204204_at",0.885312914741353,0.546665903125571,0.612156037026631,-5.7587937656421,0.452838183280187,"SLC31A2","solute carrier family 31 member 2",TRUE
+"240532_at",0.941400961503247,0.737995131154326,-0.338739564251801,-5.883949681411,-0.169074057592317,"SLC32A1","solute carrier family 32 member 1",TRUE
+"203164_at",0.710372201621696,0.183189499990485,1.37397941890347,-5.05978527987199,0.484609837683285,"SLC33A1","solute carrier family 33 member 1",TRUE
+"1554148_a_at",0.762192206662119,0.261555091282127,1.1521117373571,-5.31306176199253,0.346991619703864,"SLC33A1","solute carrier family 33 member 1",TRUE
+"203165_s_at",0.839508810008021,0.426143586841128,0.810730389119862,-5.62451733805211,0.284358994466677,"SLC33A1","solute carrier family 33 member 1",TRUE
+"243724_at",0.871660802911361,0.513175849746937,0.664582020247376,-5.72682231089558,0.218769497027408,"SLC33A1","solute carrier family 33 member 1",TRUE
+"208177_at",0.597654932724127,0.0745335019651434,1.87153347073875,-4.36404849789104,0.97155970015563,"SLC34A1","solute carrier family 34 member 1",TRUE
+"217530_at",0.992820830895496,0.966188252294149,-0.0428711513795029,-5.93878832972079,-0.0224998336772577,"SLC34A1","solute carrier family 34 member 1",TRUE
+"204124_at",0.896159990898752,0.579183668296983,0.562857131303171,-5.78654486585067,0.445434091430563,"SLC34A2","solute carrier family 34 member 2",TRUE
+"1569926_s_at",0.841088238127348,0.430928242385463,-0.802252307008077,-5.63097509166199,-0.48648693155461,"SLC34A3","solute carrier family 34 member 3",TRUE
+"1552510_at",0.841813886364358,0.434124999358563,0.79662036999649,-5.63522967332671,0.303879147970102,"SLC34A3","solute carrier family 34 member 3",TRUE
+"203306_s_at",0.812302873476553,0.358045790596292,-0.938620582824744,-5.51945189663468,-0.446924562569295,"SLC35A1","solute carrier family 35 member A1",TRUE
+"207440_at",0.615637099066718,0.0859873192217941,1.79696485487478,-4.47853546342459,0.588953842745802,"SLC35A2","solute carrier family 35 member A2",TRUE
+"209326_at",0.775716503475758,0.293020081322082,-1.07710832223835,-5.38987726124797,-0.421264464700357,"SLC35A2","solute carrier family 35 member A2",TRUE
+"207439_s_at",0.920800738105699,0.66327476054698,-0.441296527700544,-5.84527408583198,-0.157763552709332,"SLC35A2","solute carrier family 35 member A2",TRUE
+"226894_at",0.663129351367592,0.131100733683744,-1.56779546253791,-4.80854332429078,-0.604936700824272,"SLC35A3","solute carrier family 35 member A3",TRUE
+"209865_at",0.687277721925286,0.155937505760988,-1.4688189530983,-4.94019344533681,-0.751742077120142,"SLC35A3","solute carrier family 35 member A3",TRUE
+"206770_s_at",0.860561098143874,0.480025466322668,-0.718388341808059,-5.69139744644992,-0.286245751028426,"SLC35A3","solute carrier family 35 member A3",TRUE
+"224626_at",0.538508613666048,0.0439482379630468,-2.13627639937331,-3.93211627190042,-0.685943334619187,"SLC35A4","solute carrier family 35 member A4",TRUE
+"218519_at",0.872367619021891,0.515538548481323,-0.660823111722943,-5.72919853342698,-0.230969866792195,"SLC35A5","solute carrier family 35 member A5",TRUE
+"202433_at",0.622434989367596,0.092907960653142,-1.75597922599098,-4.54002281827062,-0.685177828619429,"SLC35B1","solute carrier family 35 member B1",TRUE
+"231003_at",0.908709061737317,0.620664652666078,0.501935124738095,-5.81771277099149,0.256025185610763,"SLC35B3","solute carrier family 35 member B3",TRUE
+"222691_at",0.969183235742461,0.854019871957141,0.186151323972428,-5.92281969558054,0.0800167298643881,"SLC35B3","solute carrier family 35 member B3",TRUE
+"225881_at",0.943464796017993,0.746898798519571,-0.32678325445071,-5.88780475067037,-0.16578335398775,"SLC35B4","solute carrier family 35 member B4",TRUE
+"238418_at",0.989773205191473,0.950725362418761,-0.0624996167694436,-5.93778109280962,-0.0516893894353725,"SLC35B4","solute carrier family 35 member B4",TRUE
+"225882_at",0.999127703490878,0.997182250135405,0.00357159258869094,-5.93967726764045,0.00161443449609422,"SLC35B4","solute carrier family 35 member B4",TRUE
+"222647_at",0.819479221404744,0.376759201444655,-0.901998069319655,-5.5509926746318,-0.450162483876724,"SLC35C1","solute carrier family 35 member C1",TRUE
+"218485_s_at",0.955892698633978,0.79980908801959,0.256660495883018,-5.90764922240902,0.112490023212604,"SLC35C1","solute carrier family 35 member C1",TRUE
+"238814_at",0.341198907110782,0.00852876130222859,2.88644414279621,-2.53593396698654,1.06741542679806,"SLC35C2","solute carrier family 35 member C2",TRUE
+"219447_s_at",0.709135917979769,0.181723528239721,-1.37878365386225,-5.05388554348346,-0.400112092892105,"SLC35C2","solute carrier family 35 member C2",TRUE
+"225037_at",0.940668681806864,0.734565685534812,-0.343358171194572,-5.88242382388223,-0.100495245047954,"SLC35C2","solute carrier family 35 member C2",TRUE
+"209711_at",0.834504305810205,0.413035200301705,-0.834267014316301,-5.60625609683837,-0.363726913739233,"SLC35D1","solute carrier family 35 member D1",TRUE
+"209713_s_at",0.858826390511142,0.474996269545149,-0.72673613632511,-5.68566615699262,-0.406075626506681,"SLC35D1","solute carrier family 35 member D1",TRUE
+"209712_at",0.97070558355376,0.86051739882597,-0.177771854850298,-5.92430261830103,-0.0637699886403365,"SLC35D1","solute carrier family 35 member D1",TRUE
+"233325_at",0.583823590956325,0.0647000761392683,1.94401433960084,-4.24963579445363,0.837949658849129,"SLC35D2","solute carrier family 35 member D2",TRUE
+"231437_at",0.76912869907427,0.2745841549495,1.12029704403215,-5.3462042222597,0.411302506836872,"SLC35D2","solute carrier family 35 member D2",TRUE
+"213083_at",0.784498961298069,0.307662026056362,1.0441783671875,-5.42214483784786,0.779044091835003,"SLC35D2","solute carrier family 35 member D2",TRUE
+"213082_s_at",0.78515014907967,0.310510785119299,1.03790145859361,-5.42819333958132,1.06402210857155,"SLC35D2","solute carrier family 35 member D2",TRUE
+"231341_at",0.554642754132296,0.0512161370390222,2.06114665519464,-4.05852893522246,1.42829913401278,"SLC35D3","solute carrier family 35 member D3",TRUE
+"229410_at",0.768852835478002,0.274144641739739,-1.12135202265408,-5.34511835699833,-0.348944126189071,"SLC35E1","solute carrier family 35 member E1",TRUE
+"79005_at",0.84231658612216,0.435960827879357,0.793397648430179,-5.63765156112723,0.195925936446891,"SLC35E1","solute carrier family 35 member E1",TRUE
+"235035_at",0.899748919851953,0.591357611977685,-0.544763628393695,-5.79616361502001,-0.186546851348911,"SLC35E1","solute carrier family 35 member E1",TRUE
+"220796_x_at",0.916042382946954,0.645692765589257,0.466101308077931,-5.83441920363043,0.162049909165631,"SLC35E1","solute carrier family 35 member E1",TRUE
+"227518_at",0.929234395612144,0.688989678534774,-0.405512898719454,-5.85990630930128,-0.146690929468695,"SLC35E1","solute carrier family 35 member E1",TRUE
+"222263_at",0.933452326566701,0.705633618826307,0.382638807515719,-5.86862188640832,0.110037419743154,"SLC35E1","solute carrier family 35 member E1",TRUE
+"215169_at",0.743474458360704,0.233709812964083,1.2242678140971,-5.23489039686001,1.09919055185676,"SLC35E2B///SLC35E2","solute carrier family 35 member E2B///solute carrier family 35 member E2",TRUE
+"217122_s_at",0.743474458360704,0.233846940091426,-1.22389702197509,-5.23530263338406,-0.547995419479774,"SLC35E2B///SLC35E2","solute carrier family 35 member E2B///solute carrier family 35 member E2",TRUE
+"218988_at",0.65284137151906,0.122196530530487,-1.6070744861428,-4.75442531237527,-0.876256686781396,"SLC35E3","solute carrier family 35 member E3",TRUE
+"220396_at",0.769847953580141,0.27753456159551,1.11324678030764,-5.35343765657082,0.362546232159113,"SLC35E3","solute carrier family 35 member E3",TRUE
+"1568623_a_at",0.837368340567858,0.420768016591233,0.820326656887208,-5.61713103645658,0.376961695557426,"SLC35E4","solute carrier family 35 member E4",TRUE
+"241078_at",0.952516105790337,0.782483052429319,-0.279461187617274,-5.90171597998438,-0.180447368590009,"SLC35E4","solute carrier family 35 member E4",TRUE
+"228060_at",0.864162003866305,0.491372189184787,0.699739180982204,-5.70397350201132,0.296994697015238,"SLC35F1","solute carrier family 35 member F1",TRUE
+"218826_at",0.603702127972549,0.078238745437508,1.84638237234131,-4.40303519063856,1.24816847119352,"SLC35F2","solute carrier family 35 member F2",TRUE
+"229065_at",0.631316839203356,0.102601617076953,1.70276493920947,-4.61828791498694,1.96955320869501,"SLC35F3","solute carrier family 35 member F3",TRUE
+"231520_at",0.982441995162923,0.915187262008124,0.107720051254422,-5.93403337030373,0.0908605681646808,"SLC35F3","solute carrier family 35 member F3",TRUE
+"240799_at",0.899331416659389,0.590078675274205,0.546655720433608,-5.79517204247912,0.50067734514931,"SLC35F4","solute carrier family 35 member F4",TRUE
+"226381_at",0.594972224548427,0.0715513261731471,-1.89258180512863,-4.33113571832071,-0.826016928890134,"SLC35F5","solute carrier family 35 member F5",TRUE
+"225872_at",0.664867592782765,0.132511424939255,-1.56177723395953,-4.81674245360378,-0.504498911768128,"SLC35F5","solute carrier family 35 member F5",TRUE
+"220123_at",0.723655063748891,0.200619268293984,-1.31906140221442,-5.12600122669305,-1.33888752427052,"SLC35F5","solute carrier family 35 member F5",TRUE
+"240335_at",0.955574463869973,0.796481220058669,-0.261028747072061,-5.90655132592178,-0.13632803427835,"SLC35F5","solute carrier family 35 member F5",TRUE
+"225695_at",0.823741997583852,0.390881072482672,-0.875149370767067,-5.57337841620999,-0.242084236502857,"SLC35F6","solute carrier family 35 member F6",TRUE
+"1554444_s_at",0.8269493424154,0.395196330461308,0.867071487461214,-5.57999070115384,0.238790467885288,"SLC35F6","solute carrier family 35 member F6",TRUE
+"219783_at",0.985498770484702,0.930164910513863,-0.0886392731460591,-5.93585738876427,-0.0256747990016795,"SLC35F6","solute carrier family 35 member F6",TRUE
+"204962_s_at",0.61760967235709,0.0878430474565946,1.78570384883299,-4.49553264440206,0.714781380136907,"SLC35F6///CENPA","solute carrier family 35 member F6///centromere protein A",TRUE
+"239265_at",0.729083413548563,0.211051366336961,-1.28795425489069,-5.16249667038192,-1.20372187169645,"SLC35G1","solute carrier family 35 member G1",TRUE
+"231012_at",0.85334340854827,0.460345302851437,0.751355814084158,-5.66839731001194,0.199923395758249,"SLC35G1","solute carrier family 35 member G1",TRUE
+"236219_at",0.917106560962976,0.649686047253607,0.460442015067404,-5.83694699233545,0.427423022878668,"SLC35G1","solute carrier family 35 member G1",TRUE
+"219569_s_at",0.435638443292043,0.0198477432508547,2.51043317257146,-3.26296440958056,2.16528910559263,"SLC35G2","solute carrier family 35 member G2",TRUE
+"1559494_at",0.710672261019989,0.183767169367281,1.37209466155162,-5.06209513936233,0.850010504224475,"SLC35G2","solute carrier family 35 member G2",TRUE
+"1553471_at",0.967438733768155,0.847478205312844,0.194601520306423,-5.921255335382,0.161540430385344,"SLC35G3","solute carrier family 35 member G3",TRUE
+"1553340_s_at",0.676294804179428,0.143017192214686,-1.51854866471478,-4.87490274460354,-0.751006558875067,"SLC35G4///SLC35G3///SLC35G5","solute carrier family 35 member G4///solute carrier family 35 member G3///solute carrier family 35 member G5",TRUE
+"213119_at",0.726606584292858,0.205655910231952,-1.30388986182055,-5.14389291128687,-0.536708835267238,"SLC36A1","solute carrier family 36 member 1",TRUE
+"1553272_at",0.783297012796639,0.305863210384785,1.04816304620029,-5.41828813350846,0.732964104570914,"SLC36A1","solute carrier family 36 member 1",TRUE
+"234978_at",0.882092375733396,0.539583972022838,0.623094249632933,-5.75233179567641,0.524166695310138,"SLC36A4","solute carrier family 36 member 4",TRUE
+"230874_at",0.957174671135192,0.805986492591393,0.248565303693147,-5.90963515098996,0.341213563448484,"SLC36A4","solute carrier family 36 member 4",TRUE
+"234754_at",0.758217184842835,0.25517977902685,-1.16810654797681,-5.29609130080042,-0.476882355058323,"SLC37A1","solute carrier family 37 member 1",TRUE
+"218928_s_at",0.949217179291784,0.770787686924632,0.294937271026088,-5.89740342383138,0.336246936203649,"SLC37A1","solute carrier family 37 member 1",TRUE
+"238638_at",0.171054203824867,0.00147198987333653,3.62877720396468,-0.997352009742181,2.24934090001038,"SLC37A2","solute carrier family 37 member 2",TRUE
+"223304_at",0.967642500113955,0.847850554032864,0.194120155553102,-5.92134630747362,0.0759141209977443,"SLC37A3","solute carrier family 37 member 3",TRUE
+"217289_s_at",0.599731655615302,0.0761214417146498,-1.86062411043827,-4.38100501181747,-0.940648319247833,"SLC37A4","solute carrier family 37 member 4",TRUE
+"202830_s_at",0.731548533938014,0.214854196334133,-1.27691075910069,-5.17527503086348,-0.5331367790158,"SLC37A4","solute carrier family 37 member 4",TRUE
+"224579_at",0.610033432202476,0.0825092528012387,-1.81864823138665,-4.44558901740631,-0.665577921232346,"SLC38A1","solute carrier family 38 member 1",TRUE
+"224580_at",0.748760747870936,0.241793197258014,-1.20268553974548,-5.25870487165384,-0.526016548775397,"SLC38A1","solute carrier family 38 member 1",TRUE
+"218237_s_at",0.768852835478002,0.272699133390979,-1.12483046277352,-5.34153167321285,-0.479307615701865,"SLC38A1","solute carrier family 38 member 1",TRUE
+"236857_at",0.960506476261889,0.820578654759065,-0.229509143670053,-5.9140602161812,-0.176396338575607,"SLC38A1","solute carrier family 38 member 1",TRUE
+"238347_at",0.647518308302168,0.118351715815386,1.62477706805838,-4.72969529585658,1.27085474257151,"SLC38A10","solute carrier family 38 member 10",TRUE
+"238345_at",0.812217582387393,0.356464191302128,-0.94177392874021,-5.51668214853856,-0.676706511672961,"SLC38A10","solute carrier family 38 member 10",TRUE
+"1563228_x_at",0.863835356219448,0.489785031012657,0.702332724832205,-5.70224341673191,0.533232624059253,"SLC38A10","solute carrier family 38 member 10",TRUE
+"212890_at",0.868039927215454,0.501722574435119,0.682942085531433,-5.71503045375397,0.294284823123652,"SLC38A10","solute carrier family 38 member 10",TRUE
+"242942_at",0.880919548823832,0.536849371135073,0.627338412250417,-5.7497947859113,0.237664623054738,"SLC38A10","solute carrier family 38 member 10",TRUE
+"1563226_at",0.917412255609003,0.650351744218552,0.459500074747099,-5.83736478432618,0.396570810498964,"SLC38A10","solute carrier family 38 member 10",TRUE
+"230448_at",0.931370027472813,0.695996248261199,0.395857501143594,-5.86364602795101,0.185984169757525,"SLC38A10","solute carrier family 38 member 10",TRUE
+"243231_at",0.871451481476429,0.51257995474819,0.665531571895793,-5.72622000118814,0.320800366416174,"SLC38A11","solute carrier family 38 member 11",TRUE
+"222982_x_at",0.96257574696524,0.8298485671505,-0.217448835876924,-5.91667939564769,-0.0661356907212749,"SLC38A2","solute carrier family 38 member 2",TRUE
+"220924_s_at",0.979388236370534,0.900911787105984,0.125944402849699,-5.9319606408729,0.0463868098913984,"SLC38A2","solute carrier family 38 member 2",TRUE
+"218041_x_at",0.98453870130544,0.924569596609121,0.095763091585262,-5.93521782124236,0.0342057646544607,"SLC38A2","solute carrier family 38 member 2",TRUE
+"205972_at",0.834504305810205,0.413052115567685,0.834236341227808,-5.60628021321783,0.527069148020304,"SLC38A3","solute carrier family 38 member 3",TRUE
+"220786_s_at",0.421475143999873,0.0175458429586547,2.56647287629523,-3.15769391058623,3.24675038630246,"SLC38A4","solute carrier family 38 member 4",TRUE
+"1555345_at",0.585036027492332,0.0655664970826695,1.93725268787041,-4.26043642645639,2.20298076793989,"SLC38A4","solute carrier family 38 member 4",TRUE
+"234973_at",0.112518135066489,0.00057924136556653,4.01194608858258,-0.174921267670695,2.17789079464305,"SLC38A5","solute carrier family 38 member 5",TRUE
+"214830_at",0.485255613602953,0.0280624623659519,-2.35037205389731,-3.5567763176171,-1.01577678909222,"SLC38A6","solute carrier family 38 member 6",TRUE
+"222215_at",0.8111749793648,0.355201046178858,-0.944299125359951,-5.51445799105373,-0.718321343061232,"SLC38A7","solute carrier family 38 member 7",TRUE
+"218727_at",0.876002817476733,0.524560260524705,0.646557074421943,-5.73809924796449,0.197498413580698,"SLC38A7","solute carrier family 38 member 7",TRUE
+"228951_at",0.900277982211162,0.595163194641471,0.539145392206259,-5.79908822328009,0.157774272084007,"SLC38A7","solute carrier family 38 member 7",TRUE
+"56821_at",0.963982994746471,0.835101240697288,0.210629750423002,-5.91809805001522,0.0688302757478141,"SLC38A7","solute carrier family 38 member 7",TRUE
+"235241_at",0.553930058946379,0.0506005594468772,2.06712586921871,-4.0485754181417,0.793215298341822,"SLC38A9","solute carrier family 38 member 9",TRUE
+"243709_at",0.733944330624294,0.218055632494943,1.26772988165233,-5.18582668965674,0.970157286447637,"SLC38A9","solute carrier family 38 member 9",TRUE
+"217778_at",0.830635993561085,0.404451975208215,-0.849935416103275,-5.59382876682412,-0.269897199304634,"SLC39A1","solute carrier family 39 member 1",TRUE
+"225295_at",0.250890890784173,0.00356547274145958,3.25974172850895,-1.77500263843708,1.3336335071792,"SLC39A10","solute carrier family 39 member 10",TRUE
+"227046_at",0.916565023170895,0.64728164774718,-0.463847697806068,-5.83542942873415,-0.306906123690222,"SLC39A11","solute carrier family 39 member 11",TRUE
+"1553126_a_at",0.900736310608905,0.596207536916987,0.537606687203727,-5.79988406379863,0.380496076081147,"SLC39A12","solute carrier family 39 member 12",TRUE
+"225277_at",0.893982621007426,0.570186775670251,-0.576351490704922,-5.7791727079434,-0.20122347668031,"SLC39A13","solute carrier family 39 member 13",TRUE
+"1552295_a_at",0.92249244948362,0.668885060216344,-0.433441055375861,-5.84859033355921,-0.171232358081951,"SLC39A13","solute carrier family 39 member 13",TRUE
+"212110_at",0.700061364939874,0.171858962180202,1.41193824931771,-5.01270646045512,0.713344270445765,"SLC39A14","solute carrier family 39 member 14",TRUE
+"1555434_a_at",0.722192678020526,0.19858731826519,1.32526621912689,-5.11863360311727,0.560496351199857,"SLC39A14","solute carrier family 39 member 14",TRUE
+"1555433_at",0.733012446828677,0.217504399170917,1.26930325350357,-5.18402301853644,0.631734294151906,"SLC39A14","solute carrier family 39 member 14",TRUE
+"220413_at",0.346950498371304,0.00895376594790873,2.86524531053045,-2.57810936334643,1.69255097506151,"SLC39A2","solute carrier family 39 member 2",TRUE
+"223917_s_at",0.737037362362438,0.222397069325589,-1.25544371042852,-5.19984535329803,-0.50024724883569,"SLC39A3","solute carrier family 39 member 3",TRUE
+"229677_at",0.812302873476553,0.358140541700609,-0.938431968681952,-5.51961729597088,-0.512272253221885,"SLC39A3","solute carrier family 39 member 3",TRUE
+"232115_at",0.981158705865426,0.911132310443274,-0.112892608496663,-5.93347789312566,-0.0658202465047051,"SLC39A3","solute carrier family 39 member 3",TRUE
+"219215_s_at",0.635916735157933,0.107101444897286,1.67950583272047,-4.65192892168471,1.19373046311789,"SLC39A4","solute carrier family 39 member 4",TRUE
+"1552281_at",0.55937703282623,0.0537427316332496,2.0372594323316,-4.09810518389144,1.04743387684905,"SLC39A5","solute carrier family 39 member 5",TRUE
+"231667_at",0.740610299769501,0.23046956556556,1.23307784183256,-5.22506394108985,0.451158475256028,"SLC39A5","solute carrier family 39 member 5",TRUE
+"1555460_a_at",0.660068911122272,0.128008719300908,-1.58117661400513,-4.79022446793343,-1.63365991453996,"SLC39A6","solute carrier family 39 member 6",TRUE
+"202089_s_at",0.666354937030012,0.133141289662888,-1.55910724500706,-4.82037205496456,-1.30225883501313,"SLC39A6","solute carrier family 39 member 6",TRUE
+"202088_at",0.668518995965071,0.134774981967897,-1.55223040324876,-4.8296979432253,-1.20802709266781,"SLC39A6","solute carrier family 39 member 6",TRUE
+"1556551_s_at",0.692529423238777,0.162039522348517,-1.44648897643565,-4.96893869635258,-1.24807818032887,"SLC39A6","solute carrier family 39 member 6",TRUE
+"202667_s_at",0.900958934014615,0.597082092011236,-0.536319151598985,-5.80054829600315,-0.273326762770232,"SLC39A7","solute carrier family 39 member 7",TRUE
+"222935_x_at",0.39149295959037,0.0132259377524069,2.69334560438813,-2.9151560151577,1.79103155098063,"SLC39A8","solute carrier family 39 member 8",TRUE
+"209267_s_at",0.594972224548427,0.0717102485411205,1.89144094508081,-4.33292627386973,1.56344020208482,"SLC39A8","solute carrier family 39 member 8",TRUE
+"219869_s_at",0.606900628956089,0.0806660953349112,1.83046180095717,-4.42751931745016,1.37162174862566,"SLC39A8","solute carrier family 39 member 8",TRUE
+"216504_s_at",0.661974206478491,0.129500609494268,1.57468714572476,-4.79912381561225,1.16377209301567,"SLC39A8","solute carrier family 39 member 8",TRUE
+"228945_s_at",0.79943091106207,0.334298608996926,0.987001015283464,-5.47602270553232,0.637394353389045,"SLC39A8","solute carrier family 39 member 8",TRUE
+"209266_s_at",0.847515494238763,0.446274971381757,-0.775444756844613,-5.65097395951472,-0.507430304249488,"SLC39A8","solute carrier family 39 member 8",TRUE
+"216011_at",0.527546822913581,0.0399502988018928,-2.182524604624,-3.8528803906983,-1.45890532318065,"SLC39A9","solute carrier family 39 member 9",TRUE
+"222445_at",0.641773832017075,0.112097669789905,-1.65463069228295,-4.68751894258583,-0.553733165307719,"SLC39A9","solute carrier family 39 member 9",TRUE
+"217859_s_at",0.645740804644555,0.116721210516388,-1.63243011823417,-4.71893950443942,-0.688547091861572,"SLC39A9","solute carrier family 39 member 9",TRUE
+"216009_at",0.805081687922468,0.34424751339359,-0.966455842615205,-5.49470888042832,-0.528532444298206,"SLC39A9","solute carrier family 39 member 9",TRUE
+"239667_at",0.631294544151106,0.102351676241996,-1.70408206934854,-4.61637245785388,-1.58835210917603,"SLC3A1","solute carrier family 3 member 1",TRUE
+"205799_s_at",0.906989884330247,0.615492376375037,0.509422708809229,-5.81406936426381,0.214900320364728,"SLC3A1","solute carrier family 3 member 1",TRUE
+"205800_at",0.9116561917482,0.630275374838291,-0.488098711516784,-5.82430686239469,-0.208592688711406,"SLC3A1","solute carrier family 3 member 1",TRUE
+"200924_s_at",0.620223198657182,0.0900463307742576,1.77259693733536,-4.5152177948892,0.646745017228088,"SLC3A2","solute carrier family 3 member 2",TRUE
+"233123_at",0.622434989367596,0.0927202472793084,-1.75705572938003,-4.53842114320419,-1.19778483840974,"SLC40A1","solute carrier family 40 member 1",TRUE
+"223044_at",0.754521832136014,0.247988245514114,-1.18650969217513,-5.27631240904734,-2.01595283666188,"SLC40A1","solute carrier family 40 member 1",TRUE
+"225570_at",0.872367619021891,0.515526824712454,-0.660841739870525,-5.72918678935638,-0.224293306246562,"SLC41A1","solute carrier family 41 member 1",TRUE
+"223798_at",0.904877208521835,0.610318368882665,0.516942434792839,-5.81035737493954,0.393209467970572,"SLC41A2","solute carrier family 41 member 2",TRUE
+"235299_at",0.931370027472813,0.69654148281258,0.395107756643561,-5.86393270489868,0.234912286506155,"SLC41A2","solute carrier family 41 member 2",TRUE
+"243894_at",0.934081042629428,0.708401267924867,-0.378855576601894,-5.87001533023687,-0.156185776414417,"SLC41A2","solute carrier family 41 member 2",TRUE
+"224931_at",0.865345395265289,0.494792699906983,0.694166079070996,-5.70767051363576,0.254591113731731,"SLC41A3","solute carrier family 41 member 3",TRUE
+"219175_s_at",0.90344422113846,0.603904857353261,0.526305758408033,-5.80566125126727,0.1620698014531,"SLC41A3","solute carrier family 41 member 3",TRUE
+"204394_at",0.86333554038125,0.48765379636601,0.705822951065694,-5.69990554750658,0.337891483262269,"SLC43A1","solute carrier family 43 member 1",TRUE
+"226629_at",0.929972194057784,0.690960775528324,-0.402792702886606,-5.86096886976429,-0.18002839857636,"SLC43A2","solute carrier family 43 member 2",TRUE
+"228918_at",0.96479405380661,0.837140479428607,-0.207985154153797,-5.91863612535602,-0.136524833734601,"SLC43A2","solute carrier family 43 member 2",TRUE
+"213113_s_at",0.527546822913581,0.0399225363718331,2.18286015296922,-3.85230165369788,2.54725851361224,"SLC43A3","solute carrier family 43 member 3",TRUE
+"210692_s_at",0.547343369043481,0.0478759388985494,2.09439885648922,-4.00293760432967,2.86328693160815,"SLC43A3","solute carrier family 43 member 3",TRUE
+"227620_at",0.319955762434047,0.00707501631061295,2.96748201100099,-2.37357589261927,1.00320057143865,"SLC44A1","solute carrier family 44 member 1",TRUE
+"222364_at",0.677013732819214,0.144119891512542,1.51416430218026,-4.88072901883861,0.979840475256225,"SLC44A1","solute carrier family 44 member 1",TRUE
+"224595_at",0.72464722094839,0.202119252299277,1.31451238906615,-5.13138420484517,0.612482319937078,"SLC44A1","solute carrier family 44 member 1",TRUE
+"224596_at",0.726480797733202,0.20545275090997,1.30449620060261,-5.14318122037835,0.468517397287959,"SLC44A1","solute carrier family 44 member 1",TRUE
+"228485_s_at",0.728262401376535,0.208575417341658,1.29522736369569,-5.15402989134444,0.496402470387519,"SLC44A1","solute carrier family 44 member 1",TRUE
+"228486_at",0.863660276403904,0.48908366672186,-0.703480349916376,-5.70147591843933,-0.524364283336241,"SLC44A1","solute carrier family 44 member 1",TRUE
+"224609_at",0.729083413548563,0.210853769623412,1.28853226544306,-5.16182527868125,0.576667571444743,"SLC44A2","solute carrier family 44 member 2",TRUE
+"225175_s_at",0.862388151566272,0.485352558896789,0.709601478805857,-5.69736211583459,0.331494531915302,"SLC44A2","solute carrier family 44 member 2",TRUE
+"228221_at",0.628084912651991,0.099517139429432,1.71921417487705,-4.59428679303569,1.9462810795785,"SLC44A3","solute carrier family 44 member 3",TRUE
+"1555203_s_at",0.647518308302168,0.118514065627735,-1.62401989970001,-4.73075732218776,-1.9220918124911,"SLC44A4","solute carrier family 44 member 4",TRUE
+"205597_at",0.884766357907703,0.544435656585938,-0.615592531991423,-5.75677547148167,-0.702600286536598,"SLC44A4","solute carrier family 44 member 4",TRUE
+"235763_at",0.594972224548427,0.071678054223521,-1.89167188035907,-4.3325638868907,-2.81919723904624,"SLC44A5","solute carrier family 44 member 5",TRUE
+"1552782_at",0.955615519046701,0.796634654643431,-0.260827231107592,-5.90660237903936,-0.184594581156502,"SLC44A5","solute carrier family 44 member 5",TRUE
+"1552779_a_at",0.96037751636593,0.820266833394783,-0.229915423871509,-5.91396953403338,-0.215072948211907,"SLC44A5","solute carrier family 44 member 5",TRUE
+"1569112_at",0.97689149311934,0.889290350379302,0.140812595011446,-5.93003051407435,0.138455244801312,"SLC44A5","solute carrier family 44 member 5",TRUE
+"230458_at",0.888610474399596,0.554833632492317,0.599633471329408,-5.76605615731327,0.414546788481785,"SLC45A1","solute carrier family 45 member 1",TRUE
+"220245_at",0.581852599439475,0.0641629871916096,1.94824602844914,-4.24286323757546,0.910997231828111,"SLC45A2","solute carrier family 45 member 2",TRUE
+"221644_s_at",0.683254141963065,0.152342982293134,-1.48230638513359,-4.9226585308679,-0.89885896937421,"SLC45A2","solute carrier family 45 member 2",TRUE
+"238499_at",0.694505490882266,0.163896479334747,1.43982841330357,-4.97744339073087,0.605534741604871,"SLC45A3","solute carrier family 45 member 3",TRUE
+"228696_at",0.975196332002567,0.87936596480727,0.153535270389064,-5.9282084210231,0.0709824415190958,"SLC45A3","solute carrier family 45 member 3",TRUE
+"225597_at",0.553930058946379,0.0506565516961551,2.06657932366244,-4.04948602499887,1.25614154866977,"SLC45A4","solute carrier family 45 member 4",TRUE
+"225598_at",0.615821255316333,0.0867749961394129,1.79215968499678,-4.48579781602632,0.724907205050465,"SLC45A4","solute carrier family 45 member 4",TRUE
+"1558703_at",0.697172073261335,0.16693167062414,-1.42907138415791,-4.99111102959181,-0.663487484038384,"SLC46A1","solute carrier family 46 member 1",TRUE
+"1552278_a_at",0.740476003158683,0.229267953130067,1.23636885850149,-5.22137764484162,0.505166700604266,"SLC46A1","solute carrier family 46 member 1",TRUE
+"1552279_a_at",0.947926063538122,0.762809101338177,-0.305537187092307,-5.89431669610217,-0.114878891849926,"SLC46A1","solute carrier family 46 member 1",TRUE
+"233531_at",0.995025131654789,0.976706004396236,0.029530341146299,-5.93925875063216,0.0202493564466115,"SLC46A1","solute carrier family 46 member 1",TRUE
+"223816_at",0.682440016647909,0.149880927661785,1.49169463967682,-4.91037667672702,0.769198756832992,"SLC46A2","solute carrier family 46 member 2",TRUE
+"214719_at",0.710842845257879,0.184292425529513,-1.37038497848526,-5.06418815524756,-1.80289438130995,"SLC46A3","solute carrier family 46 member 3",TRUE
+"219525_at",0.94118897722809,0.736511334573995,-0.340736939782622,-5.88329231241485,-0.396322207676895,"SLC47A1","solute carrier family 47 member 1",TRUE
+"231068_at",0.984244246588495,0.923127941814823,-0.0975993793745569,-5.9350449580425,-0.0611709302270107,"SLC47A2","solute carrier family 47 member 2",TRUE
+"218417_s_at",0.886024094987978,0.548694830035628,0.609036189283187,-5.76061665145726,0.403760348671476,"SLC48A1","solute carrier family 48 member 1",TRUE
+"48106_at",0.908882763411412,0.621546834187438,0.500660954709101,-5.81832753173451,0.321618714357475,"SLC48A1","solute carrier family 48 member 1",TRUE
+"218416_s_at",0.98539961718117,0.927785114225468,0.0916685760188273,-5.93559145564228,0.0510096026813116,"SLC48A1","solute carrier family 48 member 1",TRUE
+"205592_at",0.966532288376818,0.843806385131067,-0.199350913312109,-5.92034572475696,-0.0876605826444381,"SLC4A1","solute carrier family 4 member 1 (Diego blood group)",TRUE
+"1552713_a_at",0.989524702314661,0.948435132433067,0.0654087655204603,-5.93759989016318,0.0285991519403508,"SLC4A1","solute carrier family 4 member 1 (Diego blood group)",TRUE
+"206830_at",0.942502815705589,0.742421579828333,-0.332789314043206,-5.88588534877198,-0.150170999303296,"SLC4A10","solute carrier family 4 member 10",TRUE
+"223748_at",0.973048241540182,0.86942104191059,-0.166310356440382,-5.9262207084371,-0.102287769440878,"SLC4A11","solute carrier family 4 member 11",TRUE
+"233550_s_at",0.993225426079816,0.968175360375783,-0.0403501501788579,-5.93889050751817,-0.0193666061884112,"SLC4A11","solute carrier family 4 member 11",TRUE
+"1558201_s_at",0.770807031642694,0.27931414437187,1.10902065573159,-5.35775417188482,0.334446470508666,"SLC4A1AP","solute carrier family 4 member 1 adaptor protein",TRUE
+"218682_s_at",0.796963640275795,0.329896662783024,0.996225671583454,-5.46751638355402,0.262270162239638,"SLC4A1AP","solute carrier family 4 member 1 adaptor protein",TRUE
+"202111_at",0.199181589554674,0.00220252838267359,-3.46157672514268,-1.352069568875,-2.02854209388336,"SLC4A2","solute carrier family 4 member 2",TRUE
+"205918_at",0.953983577550391,0.788207649542629,0.271911593445635,-5.90373604575303,0.177581713987876,"SLC4A3","solute carrier family 4 member 3",TRUE
+"203908_at",0.171054203824867,0.00145533992873564,3.63347906186866,-0.987330550149378,1.76533292028341,"SLC4A4","solute carrier family 4 member 4",TRUE
+"1554027_a_at",0.631316839203356,0.1025867689984,1.70284310888999,-4.61817426654582,1.64549771890827,"SLC4A4","solute carrier family 4 member 4",TRUE
+"210738_s_at",0.6467442083288,0.1177801935497,1.627449482958,-4.72594383926646,1.46798615744184,"SLC4A4","solute carrier family 4 member 4",TRUE
+"210739_x_at",0.847515494238763,0.446288405937416,0.775421538788957,-5.65099100292808,0.272845690289793,"SLC4A4","solute carrier family 4 member 4",TRUE
+"211494_s_at",0.940900986249919,0.735322510132104,0.342338266010262,-5.8827625296081,0.2497591143984,"SLC4A4","solute carrier family 4 member 4",TRUE
+"204296_at",0.672164152353115,0.138016256737066,1.5387878775982,-4.84783365852768,0.933858012798947,"SLC4A5","solute carrier family 4 member 5",TRUE
+"1555277_a_at",0.843452046162121,0.438128830617038,0.789602558993698,-5.6404917397734,0.400348651212137,"SLC4A5","solute carrier family 4 member 5",TRUE
+"221723_s_at",0.849935057946582,0.452273852562305,0.765119190108355,-5.65850598929925,0.32611865440663,"SLC4A5","solute carrier family 4 member 5",TRUE
+"201082_s_at",0.864185284488194,0.491467347706921,0.699583837310738,-5.70407693395436,0.213584283281362,"SLC4A5///DCTN1","solute carrier family 4 member 5///dynactin subunit 1",TRUE
+"209884_s_at",0.842224301155785,0.435783496840032,0.79370858014813,-5.63741829729147,0.485822202502579,"SLC4A7","solute carrier family 4 member 7",TRUE
+"207603_at",0.874834820370747,0.521552419503249,0.651298250285519,-5.73516186591416,0.655156283332738,"SLC4A7","solute carrier family 4 member 7",TRUE
+"207604_s_at",0.881970070870254,0.539248823375974,0.623613786972643,-5.75202212555097,0.349919198894921,"SLC4A7","solute carrier family 4 member 7",TRUE
+"210286_s_at",0.929234395612144,0.68881878451827,0.405748885984153,-5.85981379632914,0.282649387180415,"SLC4A7","solute carrier family 4 member 7",TRUE
+"228935_at",0.182644973816866,0.00172032593083091,-3.56424693350339,-1.13464979388972,-3.56530096238715,"SLC4A8","solute carrier family 4 member 8",TRUE
+"207056_s_at",0.348076056756175,0.00905920857364493,-2.86013464284735,-2.58825809255991,-2.75906439050232,"SLC4A8","solute carrier family 4 member 8",TRUE
+"1554113_a_at",0.407748633394319,0.0156889850931957,-2.61694239950337,-3.06189219167132,-1.56637056204928,"SLC4A8","solute carrier family 4 member 8",TRUE
+"228175_at",0.724623760403195,0.202027849118163,-1.31478883413104,-5.13105752762065,-0.544150329258357,"SLC4A8","solute carrier family 4 member 8",TRUE
+"233183_at",0.0944689166386564,0.00039048880037195,4.17302559761832,0.172901682653229,1.7846844170486,"SLC4A9","solute carrier family 4 member 9",TRUE
+"224053_s_at",0.93150597990479,0.697142993904419,0.39428089435561,-5.86424824829138,0.241698164908707,"SLC4A9","solute carrier family 4 member 9",TRUE
+"219125_s_at",0.677509122383198,0.14492374038612,-1.51098546468555,-4.88494488680137,-0.860595171808678,"SLC50A1","solute carrier family 50 member 1",TRUE
+"229230_at",0.630603891142543,0.10196300444683,1.70613572236263,-4.6133836832982,0.909054154058543,"SLC51A","solute carrier family 51 alpha subunit",TRUE
+"230830_at",0.822173415758858,0.386627431999018,-0.883168769931568,-5.56675770789302,-0.51026951428711,"SLC51B","solute carrier family 51 beta subunit",TRUE
+"220756_s_at",0.638046983575116,0.109241112267886,1.66873536895692,-4.66738826927915,1.17641621304169,"SLC52A1","solute carrier family 52 member 1",TRUE
+"218151_x_at",0.748719297994831,0.241699050930201,1.20293375250473,-5.2584330753007,0.354923491378464,"SLC52A2","solute carrier family 52 member 2",TRUE
+"222155_s_at",0.820536502908875,0.380064224578972,0.895656184408543,-5.55633686014833,0.395109490118548,"SLC52A2","solute carrier family 52 member 2",TRUE
+"233451_at",0.826165259413521,0.394383416016331,0.868588829945499,-5.57875300189513,0.312602304624396,"SLC52A3","solute carrier family 52 member 3",TRUE
+"228236_at",0.990984475090957,0.957855081902946,-0.0534465612582198,-5.93829226368448,-0.0595212308144264,"SLC52A3","solute carrier family 52 member 3",TRUE
+"242773_at",0.704449222279154,0.176389105927454,1.396529318306,-5.03194542986619,0.942738979991731,"SLC5A1","solute carrier family 5 member 1",TRUE
+"206628_at",0.93500920855517,0.711154237544888,-0.375097989643978,-5.87138581115589,-0.211042423679699,"SLC5A1","solute carrier family 5 member 1",TRUE
+"239707_at",0.739189560382301,0.226032608751364,-1.24529565321982,-5.21133607744307,-0.79971984344965,"SLC5A10","solute carrier family 5 member 10",TRUE
+"237254_at",0.951810226174863,0.779147054307567,-0.28386833311058,-5.90051136807077,-0.223346317551127,"SLC5A11","solute carrier family 5 member 11",TRUE
+"231424_at",0.686108994812404,0.154620626938918,-1.47373058048305,-4.93382286680572,-1.51430151559026,"SLC5A12","solute carrier family 5 member 12",TRUE
+"1561951_at",0.780899817077006,0.302676340621782,-1.05526348016018,-5.41138303357856,-1.15196029284216,"SLC5A12","solute carrier family 5 member 12",TRUE
+"214389_at",0.806221445484273,0.346939774986232,0.960966085819396,-5.49964115252217,0.998172949114636,"SLC5A12","solute carrier family 5 member 12",TRUE
+"207771_at",0.877275291808937,0.526769447872787,0.643084271660225,-5.74023773435785,0.225694977810213,"SLC5A2","solute carrier family 5 member 2",TRUE
+"1553313_s_at",0.59730739400815,0.0731954191102809,1.88088492659565,-4.34945779286115,0.656909417495093,"SLC5A3","solute carrier family 5 member 3",TRUE
+"212944_at",0.868397087637799,0.503410744668364,0.680221175811966,-5.7167973761964,0.330831323352031,"SLC5A3","solute carrier family 5 member 3",TRUE
+"213164_at",0.883515015273005,0.541703673979178,0.619812341133507,-5.75428223039125,0.301095936459317,"SLC5A3","solute carrier family 5 member 3",TRUE
+"213167_s_at",0.885694554133555,0.547460893479318,0.610932865280996,-5.75950951943753,0.296876637927953,"SLC5A3","solute carrier family 5 member 3",TRUE
+"215960_at",0.952613441433926,0.782816603242183,0.279020849965258,-5.90183531028918,0.188593001487039,"SLC5A4","solute carrier family 5 member 4",TRUE
+"211123_at",0.826140850652187,0.394326434009513,-0.868695265306772,-5.57866610685773,-0.335063969813948,"SLC5A5","solute carrier family 5 member 5",TRUE
+"204087_s_at",0.998347572104896,0.993216604244604,-0.00859827356377646,-5.93964747208587,-0.00412233013776486,"SLC5A6","solute carrier family 5 member 6",TRUE
+"220722_s_at",0.734042693548791,0.218355159851959,-1.26687622879891,-5.18680449393304,-0.960077286108252,"SLC5A7","solute carrier family 5 member 7",TRUE
+"222967_at",0.8920930097751,0.56292481501025,0.587322899538175,-5.77305424230915,0.467335570619005,"SLC5A7","solute carrier family 5 member 7",TRUE
+"237503_at",0.911046362974546,0.6289090991646,0.49005977438912,-5.82338321932943,0.344878845458724,"SLC5A8","solute carrier family 5 member 8",TRUE
+"1569337_at",0.603702127972549,0.0781645817639417,1.84687552204427,-4.40227436309587,0.498613947272421,"SLC5A9","solute carrier family 5 member 9",TRUE
+"232378_at",0.854350135157525,0.465252809205441,-0.743058093779897,-5.67427848076479,-0.52987647148727,"SLC5A9","solute carrier family 5 member 9",TRUE
+"205152_at",0.93613089056626,0.71449779372167,-0.370541677755183,-5.87302952656138,-0.301472537848803,"SLC6A1","solute carrier family 6 member 1",TRUE
+"226903_s_at",0.522667179791589,0.0385309168900041,2.19995710150939,-3.82274127701312,1.32925849761522,"SLC6A10P///SLC6A8","solute carrier family 6 member 10, pseudogene///solute carrier family 6 member 8",TRUE
+"226904_at",0.989108041907445,0.947019565008253,0.0672071678810097,-5.9374837517782,0.0383364560500943,"SLC6A10P///SLC6A8","solute carrier family 6 member 10, pseudogene///solute carrier family 6 member 8",TRUE
+"215812_s_at",0.97345342693821,0.871847637806767,-0.163190659853867,-5.92672072740575,-0.113482088179961,"SLC6A10PB///SLC6A10P///SLC6A8","solute carrier family 6 member 8 pseudogene///solute carrier family 6 member 10, pseudogene///solute carrier family 6 member 8",TRUE
+"1554724_at",0.811844013927892,0.356021425709626,0.942658389045602,-5.51590375012501,0.772700641440307,"SLC6A11","solute carrier family 6 member 11",TRUE
+"207048_at",0.86219003266709,0.485095835870783,0.710023648055308,-5.69707713864822,0.463667080624394,"SLC6A11","solute carrier family 6 member 11",TRUE
+"240348_at",0.969882914559333,0.856539604536087,-0.182900190976351,-5.92340313355547,-0.153184365203282,"SLC6A11","solute carrier family 6 member 11",TRUE
+"230286_at",0.999325037419579,0.997771445683307,-0.00282476509287189,-5.93967959432807,-0.00194380104686687,"SLC6A11","solute carrier family 6 member 11",TRUE
+"206058_at",0.966051687342135,0.84130820575373,0.202584912905679,-5.91971384102272,0.0986161960834693,"SLC6A12","solute carrier family 6 member 12",TRUE
+"207184_at",0.929234395612144,0.688805689598929,0.40576696970342,-5.8598067048689,0.117575600778507,"SLC6A13","solute carrier family 6 member 13",TRUE
+"237058_x_at",0.97304633500821,0.869010305974471,-0.166838575913514,-5.92613511162089,-0.115797759470493,"SLC6A13","solute carrier family 6 member 13",TRUE
+"219795_at",0.801547748171611,0.338396312678588,0.978488855916705,-5.48380812237558,1.42493695133857,"SLC6A14","solute carrier family 6 member 14",TRUE
+"206376_at",0.1932921418089,0.00198329934256594,3.50520382188157,-1.25984760006338,4.49151125736471,"SLC6A15","solute carrier family 6 member 15",TRUE
+"232263_at",0.219371608436167,0.00268020547664124,3.37962408675573,-1.52457956189181,3.8590144217734,"SLC6A15","solute carrier family 6 member 15",TRUE
+"240419_at",0.412444326023181,0.0165074379549834,2.59404177724554,-3.10547659830158,2.54633668245956,"SLC6A15","solute carrier family 6 member 15",TRUE
+"239352_at",0.45894822559666,0.0229123374478416,2.44456622983954,-3.38514046236636,1.70114917603728,"SLC6A15","solute carrier family 6 member 15",TRUE
+"1569916_at",0.953983577550391,0.788042896268606,0.272128642335666,-5.90367873615467,0.281295866714683,"SLC6A15","solute carrier family 6 member 15",TRUE
+"1569940_at",0.950240579085849,0.774223101205033,0.29038384146553,-5.89869621485788,0.109719689594484,"SLC6A16","solute carrier family 6 member 16",TRUE
+"219820_at",0.970540753946729,0.859852883723449,-0.178628231865263,-5.92415418758499,-0.118121006239121,"SLC6A16","solute carrier family 6 member 16",TRUE
+"229925_at",0.746172020724,0.2376327032883,-1.21372467243785,-5.24656983313871,-0.788137529157128,"SLC6A17","solute carrier family 6 member 17",TRUE
+"233287_at",0.834265235157814,0.412333729260686,0.835539719382747,-5.6052547157785,0.368080911228125,"SLC6A17","solute carrier family 6 member 17",TRUE
+"238215_at",0.988713664405312,0.945525726578523,0.069105255816054,-5.93735776070439,0.0455006858117146,"SLC6A18","solute carrier family 6 member 18",TRUE
+"231021_at",0.561084367279569,0.0547076499673961,-2.02840059681195,-4.1127052218185,-1.44307975496733,"SLC6A19","solute carrier family 6 member 19",TRUE
+"238177_at",0.627092759817312,0.0984977056089112,1.72474625844633,-4.5861761787947,0.73316726533517,"SLC6A19","solute carrier family 6 member 19",TRUE
+"231480_at",0.910973995492817,0.628676192006127,0.490394268389031,-5.82322531438465,0.321480458214994,"SLC6A19","solute carrier family 6 member 19",TRUE
+"216611_s_at",0.328663980090165,0.00779282166081001,2.92565914852658,-2.45758698482458,1.89488831513434,"SLC6A2","solute carrier family 6 member 2",TRUE
+"215715_at",0.46481156911694,0.0239450561357187,2.42420704354429,-3.42255203771611,1.53245100087576,"SLC6A2","solute carrier family 6 member 2",TRUE
+"216610_at",0.528056136690037,0.0405838372519299,2.17492424769569,-3.86597437152835,1.69103214808246,"SLC6A2","solute carrier family 6 member 2",TRUE
+"210353_s_at",0.582628933729382,0.0643938293971532,1.94642342475499,-4.24578143910687,1.35364088517495,"SLC6A2","solute carrier family 6 member 2",TRUE
+"239394_at",0.683838837468118,0.152746645021287,1.48077894822183,-4.92465083689259,1.14999566928627,"SLC6A2","solute carrier family 6 member 2",TRUE
+"217213_at",0.767965891104819,0.270949541075513,-1.12905872683079,-5.33715860859121,-0.920077320245307,"SLC6A2","solute carrier family 6 member 2",TRUE
+"217621_at",0.817560991958296,0.3700082230234,0.915067307190068,-5.53986966578903,0.981599560904425,"SLC6A2","solute carrier family 6 member 2",TRUE
+"217214_s_at",0.986285942607238,0.932948962078975,0.0850964597154804,-5.93615707354653,0.0547631311273582,"SLC6A2","solute carrier family 6 member 2",TRUE
+"234291_s_at",0.966111788889917,0.842248479652221,0.201367430777641,-5.91995291085708,0.109224542357076,"SLC6A20","solute carrier family 6 member 20",TRUE
+"219614_s_at",0.997466539876354,0.98713730853394,0.0163046121789531,-5.93955400053174,0.0150728260375277,"SLC6A20","solute carrier family 6 member 20",TRUE
+"206836_at",0.884683644631586,0.543946978318859,-0.616346513563239,-5.75633119202181,-0.528779214525981,"SLC6A3","solute carrier family 6 member 3",TRUE
+"241811_x_at",0.813065886130395,0.362872581120769,-0.929054548198515,-5.52780202420566,-0.789908119650884,"SLC6A4","solute carrier family 6 member 4",TRUE
+"242009_at",0.92466349766724,0.674120698122089,0.426135110243692,-5.85162208927224,0.327311569539527,"SLC6A4","solute carrier family 6 member 4",TRUE
+"207519_at",0.961395512423249,0.824874089816933,-0.223916495071526,-5.91529228214874,-0.109036675976055,"SLC6A4","solute carrier family 6 member 4",TRUE
+"236508_at",0.746535697909741,0.238304299659578,-1.2119329016786,-5.24854601711028,-0.671940615834004,"SLC6A5","solute carrier family 6 member 5",TRUE
+"210810_s_at",0.895657764833717,0.575153263242743,0.568889098675863,-5.78327043849848,0.294218191513797,"SLC6A5","solute carrier family 6 member 5",TRUE
+"228756_at",0.630603891142543,0.101550866279509,-1.70832065220317,-4.61020089169758,-0.826841745934227,"SLC6A6","solute carrier family 6 member 6",TRUE
+"205920_at",0.656693876264681,0.124826050143133,-1.59523356957828,-4.7708494423863,-1.40569833153961,"SLC6A6","solute carrier family 6 member 6",TRUE
+"228754_at",0.768852835478002,0.272349813663085,-1.12567307944905,-5.34066135753972,-0.536725846193718,"SLC6A6","solute carrier family 6 member 6",TRUE
+"211030_s_at",0.956734254923335,0.803697030276325,0.251563525238816,-5.90890699640132,0.103178699364525,"SLC6A6","solute carrier family 6 member 6",TRUE
+"205921_s_at",0.961644868810744,0.826129578147064,-0.2222832379427,-5.91564638409931,-0.128167538570605,"SLC6A6","solute carrier family 6 member 6",TRUE
+"208494_at",0.773107052530371,0.28394685838087,1.09810990913839,-5.36883086822346,0.29522318705824,"SLC6A7","solute carrier family 6 member 7",TRUE
+"202219_at",0.759878256460865,0.257689865651125,-1.1617741131187,-5.30283454177385,-1.40635836269455,"SLC6A8","solute carrier family 6 member 8",TRUE
+"210854_x_at",0.89880856206786,0.588628551569887,-0.548803515576617,-5.79404241824304,-0.386569547826147,"SLC6A8","solute carrier family 6 member 8",TRUE
+"213843_x_at",0.998347572104896,0.992520746969627,0.00948033176207773,-5.93963970522177,0.00710793912539742,"SLC6A8","solute carrier family 6 member 8",TRUE
+"207043_s_at",0.950214160603623,0.773892101830542,0.290822286362855,-5.89857260137072,0.146506276263948,"SLC6A9","solute carrier family 6 member 9",TRUE
+"212290_at",0.301965976738642,0.0057790446803128,3.05451985877102,-2.19732073145833,1.26512893160786,"SLC7A1","solute carrier family 7 member 1",TRUE
+"212295_s_at",0.356547077571111,0.00963182503104766,2.83333339620617,-2.64135676790815,0.851475327920125,"SLC7A1","solute carrier family 7 member 1",TRUE
+"206566_at",0.360966595144878,0.010378408551765,2.80058122592816,-2.70595900459932,1.3499713400864,"SLC7A1","solute carrier family 7 member 1",TRUE
+"212292_at",0.5897618614591,0.0679780260727154,1.91883866329855,-4.28971827897924,0.581717943919883,"SLC7A1","solute carrier family 7 member 1",TRUE
+"215979_s_at",0.79871392967667,0.333221608638474,-0.989250177296203,-5.47395532078996,-0.569912702158271,"SLC7A1","solute carrier family 7 member 1",TRUE
+"220868_s_at",0.993225426079816,0.967847360221179,-0.0407662579915578,-5.93887406889634,-0.025128342942681,"SLC7A10","solute carrier family 7 member 10",TRUE
+"209921_at",0.463552233135475,0.0236373136072537,2.43018741293141,-3.41158026476816,1.7638088215875,"SLC7A11","solute carrier family 7 member 11",TRUE
+"217678_at",0.519244778760877,0.0373514351141569,2.21489249481382,-3.79680277493139,1.45975117516289,"SLC7A11","solute carrier family 7 member 11",TRUE
+"207528_s_at",0.57460012602512,0.060539955806243,1.9776376537028,-4.19554704095788,0.786356770533128,"SLC7A11","solute carrier family 7 member 11",TRUE
+"1562253_at",0.916057757219214,0.645986035072082,0.465685161680318,-5.83460611040113,0.272342680618324,"SLC7A11-AS1","SLC7A11 antisense RNA 1",TRUE
+"238287_at",0.950143995989534,0.773357258518998,-0.291530867939449,-5.8983724355226,-0.192587729998571,"SLC7A13","solute carrier family 7 member 13",TRUE
+"232904_at",0.888686718625571,0.555070842436569,0.599271237295386,-5.76626407620456,0.385843382250742,"SLC7A14","solute carrier family 7 member 14",TRUE
+"1556641_at",0.990519877107938,0.952058538304094,-0.0608064154835185,-5.93788276416035,-0.0450325037968131,"SLC7A14","solute carrier family 7 member 14",TRUE
+"207626_s_at",0.724640525769763,0.202104131275046,-1.31455811524258,-5.13133017388195,-1.690143436712,"SLC7A2","solute carrier family 7 member 2",TRUE
+"225516_at",0.8017109011727,0.339179336852596,-0.97687034937041,-5.48528149430957,-2.01967761084274,"SLC7A2","solute carrier family 7 member 2",TRUE
+"230658_at",0.981508003489034,0.91212343087876,-0.111628034523436,-5.93361609757782,-0.0782340685842082,"SLC7A2","solute carrier family 7 member 2",TRUE
+"230597_at",0.883515015273005,0.541747063711548,-0.619745233042473,-5.75432200912086,-0.248414761007902,"SLC7A3","solute carrier family 7 member 3",TRUE
+"214406_s_at",0.390415895588582,0.0130459961818078,2.69944174859282,-2.90336274803282,1.26959909032192,"SLC7A4","solute carrier family 7 member 4",TRUE
+"205864_at",0.55679801038721,0.0519994036040956,2.05363088286637,-4.07101363193324,0.818880052378389,"SLC7A4","solute carrier family 7 member 4",TRUE
+"201195_s_at",0.557512088623721,0.0522793015408927,2.0509696687998,-4.07542710704146,1.34512550804211,"SLC7A5","solute carrier family 7 member 5",TRUE
+"203579_s_at",0.721046612088315,0.197211358704502,-1.32949610738099,-5.11359432359914,-0.504166606292655,"SLC7A6","solute carrier family 7 member 6",TRUE
+"203580_s_at",0.764077045023402,0.264066056792602,-1.14589117722808,-5.31960623960141,-0.426891834767499,"SLC7A6","solute carrier family 7 member 6",TRUE
+"203578_s_at",0.809930331505913,0.353502787362956,-0.947703738127571,-5.51145061080774,-0.362602775342051,"SLC7A6","solute carrier family 7 member 6",TRUE
+"229153_at",0.94895689004559,0.768392751526777,0.298115374406427,-5.89648929093596,0.0948400813126797,"SLC7A6OS","solute carrier family 7 member 6 opposite strand",TRUE
+"232057_at",0.974138689437749,0.874229022376084,-0.160130699403608,-5.92720199726395,-0.0535877189403529,"SLC7A6OS","solute carrier family 7 member 6 opposite strand",TRUE
+"204588_s_at",0.88113080359582,0.537677715856373,0.626051580349387,-5.75056576006976,0.511244704847543,"SLC7A7","solute carrier family 7 member 7",TRUE
+"217248_s_at",0.774479064996015,0.290909493512998,-1.08195141069752,-5.38505599760994,-1.43699747543401,"SLC7A8","solute carrier family 7 member 8",TRUE
+"216092_s_at",0.937655803006818,0.724297305609327,-0.357233229566055,-5.87771706481154,-0.381407492836177,"SLC7A8","solute carrier family 7 member 8",TRUE
+"216603_at",0.944861000530823,0.752138734816699,0.319769551928031,-5.89000237555446,0.535421947878269,"SLC7A8","solute carrier family 7 member 8",TRUE
+"202752_x_at",0.968269082055813,0.850854632178015,-0.190238250976352,-5.92207173481712,-0.251738893175085,"SLC7A8","solute carrier family 7 member 8",TRUE
+"216604_s_at",0.985498770484702,0.929946000122755,0.0889178937890817,-5.93583330236968,0.101139118882715,"SLC7A8","solute carrier family 7 member 8",TRUE
+"220135_s_at",0.747444205744785,0.239223157866081,1.20948761505692,-5.25123889463757,0.421493948139294,"SLC7A9","solute carrier family 7 member 9",TRUE
+"241752_at",0.457531863501901,0.0227546985715251,2.44774854763254,-3.37927742647161,1.39870329979088,"SLC8A1","solute carrier family 8 member A1",TRUE
+"235518_at",0.502810516099457,0.032516962687681,2.28097787400166,-3.68076725063923,3.20505561417756,"SLC8A1","solute carrier family 8 member A1",TRUE
+"238546_at",0.533009393263704,0.0420070868874861,2.15823422679426,-3.89462856295285,2.49155010470511,"SLC8A1","solute carrier family 8 member A1",TRUE
+"210804_x_at",0.62110896023334,0.0916017364519628,1.76350923884807,-4.52880414612176,0.98699549643232,"SLC8A1","solute carrier family 8 member A1",TRUE
+"207053_at",0.643688366500038,0.114361654888775,1.6436655490811,-4.70307859860187,1.02794476854227,"SLC8A1","solute carrier family 8 member A1",TRUE
+"1561615_s_at",0.644953768720197,0.115383957130552,1.63877399367484,-4.70999420465603,1.25496508153785,"SLC8A1","solute carrier family 8 member A1",TRUE
+"1561614_at",0.655745626967443,0.124284016240604,1.59765725063586,-4.76749532301731,0.994840031851848,"SLC8A1","solute carrier family 8 member A1",TRUE
+"1556583_a_at",0.705559553212919,0.177630842045951,1.39236080303161,-5.03712010710089,1.25631036591319,"SLC8A1","solute carrier family 8 member A1",TRUE
+"1565306_a_at",0.864656349564184,0.492013273497688,0.698692961804481,-5.70466967951772,0.468083176300941,"SLC8A1","solute carrier family 8 member A1",TRUE
+"211805_s_at",0.873540013139054,0.518885341240087,0.655514883573894,-5.73253215812799,0.462291634263911,"SLC8A1","solute carrier family 8 member A1",TRUE
+"1564985_a_at",0.966051687342135,0.841322184556232,0.202566810632522,-5.91971740617263,0.128011065516376,"SLC8A1","solute carrier family 8 member A1",TRUE
+"1558920_at",0.725168361556674,0.20358212157508,-1.31010119289286,-5.13658909362848,-1.1955645732294,"SLC8A1-AS1","SLC8A1 antisense RNA 1",TRUE
+"244620_at",0.954577684533304,0.792929393063862,-0.265696707675527,-5.90535775870978,-0.203090721864425,"SLC8A1-AS1","SLC8A1 antisense RNA 1",TRUE
+"215267_s_at",0.973071267819624,0.8705710762077,-0.164831632902586,-5.92645889265178,-0.0622890126540439,"SLC8A2","solute carrier family 8 member A2",TRUE
+"1562403_a_at",0.85334340854827,0.460571176182598,0.750972746993393,-5.66867017823794,0.557412477525276,"SLC8A3","solute carrier family 8 member A3",TRUE
+"1568859_a_at",0.893635011091274,0.569085163815208,-0.57801118985538,-5.77825430712008,-0.218513192475626,"SLC8A3","solute carrier family 8 member A3",TRUE
+"218749_s_at",0.499428826990278,0.0315092741561397,2.29587655949532,-3.65432870531276,0.929619334624924,"SLC8B1","solute carrier family 8 member B1",TRUE
+"222727_s_at",0.624331975868069,0.0956928892333344,1.74022320308023,-4.56338242057091,0.786523053680348,"SLC8B1","solute carrier family 8 member B1",TRUE
+"1554728_at",0.899998627338565,0.59458051753388,-0.540004464951402,-5.79864293635248,-0.372535737601606,"SLC9A1","solute carrier family 9 member A1",TRUE
+"209453_at",0.9904530450668,0.951939955468043,-0.0609570142705514,-5.93787383427219,-0.036172228333001,"SLC9A1","solute carrier family 9 member A1",TRUE
+"244561_at",0.993863709454116,0.970989980364674,-0.0367797570608377,-5.93902462732022,-0.0284911744560432,"SLC9A1","solute carrier family 9 member A1",TRUE
+"208039_at",0.784789297644843,0.309179044678013,1.04083070751342,-5.42537476658072,0.462818442648686,"SLC9A2","solute carrier family 9 member A2",TRUE
+"211116_at",0.805804400675445,0.34602574219125,-0.962826614934772,-5.49797243672833,-1.10216688794822,"SLC9A2","solute carrier family 9 member A2",TRUE
+"207212_at",0.454204416450233,0.0219729434204091,2.46383900918706,-3.34957006398031,1.01151690287,"SLC9A3","solute carrier family 9 member A3",TRUE
+"201349_at",0.357623802010093,0.00967399365656932,-2.83142015311127,-2.64513929894515,-2.27038790383017,"SLC9A3R1","SLC9A3 regulator 1",TRUE
+"209830_s_at",0.910271599367218,0.627055844832225,-0.492722934086699,-5.82212310150389,-0.397517701101756,"SLC9A3R2","SLC9A3 regulator 2",TRUE
+"1559092_at",0.711989638658417,0.185966261641422,1.36496230780679,-5.07081228047766,0.916963065546145,"SLC9A5","solute carrier family 9 member A5",TRUE
+"232564_at",0.778397054392363,0.298304964591146,-1.06509002053017,-5.40175784721952,-0.409173259816127,"SLC9A5","solute carrier family 9 member A5",TRUE
+"220650_s_at",0.947778780715578,0.761665488930247,-0.307059431492371,-5.89386454431215,-0.300155771237595,"SLC9A5","solute carrier family 9 member A5",TRUE
+"203909_at",0.69794616906853,0.168884024659467,1.42223480620618,-4.99975380982238,1.60904465274344,"SLC9A6","solute carrier family 9 member A6",TRUE
+"214860_at",0.873595434130859,0.518996376615246,0.655339099297697,-5.73264211141928,0.610634361615051,"SLC9A7","solute carrier family 9 member A7",TRUE
+"1558105_a_at",0.909587512331256,0.624275654325202,0.496724911060576,-5.82021695710583,0.383438866141338,"SLC9A7","solute carrier family 9 member A7",TRUE
+"226550_at",0.929088231432081,0.68782422547319,0.407122736740206,-5.8592741602584,0.296462289080051,"SLC9A7","solute carrier family 9 member A7",TRUE
+"1552671_a_at",0.991059530537351,0.958174057246872,-0.0530416508235945,-5.93831326209491,-0.0523631233297044,"SLC9A7","solute carrier family 9 member A7",TRUE
+"212947_at",0.842167419664876,0.435501344852604,-0.794203465419188,-5.63704685245921,-0.285414828826738,"SLC9A8","solute carrier family 9 member A8",TRUE
+"227791_at",0.8494633146363,0.450561245989075,-0.768058503817226,-5.65637160201669,-0.730175402176254,"SLC9A9","solute carrier family 9 member A9",TRUE
+"242587_at",0.940900986249919,0.735322355767557,0.342338473995849,-5.88276246063862,0.25497492188993,"SLC9A9","solute carrier family 9 member A9",TRUE
+"229491_at",0.679582597949812,0.146860789323749,1.5033842308026,-4.89499713036168,1.24123240706439,"SLC9B2","solute carrier family 9 member B2",TRUE
+"1564746_at",0.721297082581089,0.197497280453972,1.32861524971266,-5.11464484823734,0.929064912221639,"SLC9B2","solute carrier family 9 member B2",TRUE
+"1563495_at",0.821187434813103,0.382514082522443,0.890978594395618,-5.56025621802767,0.354971438487859,"SLC9C2","solute carrier family 9 member C2 (putative)",TRUE
+"1554988_at",0.983326118527016,0.918724245317157,0.103210684137297,-5.93449639892031,0.0987137024188032,"SLC9C2","solute carrier family 9 member C2 (putative)",TRUE
+"207308_at",0.682539393883246,0.150196949939199,1.49048259546019,-4.91196579862638,0.840322320427529,"SLCO1A2","solute carrier organic anion transporter family member 1A2",TRUE
+"211481_at",0.724970327905974,0.202699831828654,1.31275872048455,-5.13345517631545,1.09995241001045,"SLCO1A2","solute carrier organic anion transporter family member 1A2",TRUE
+"211480_s_at",0.946050828306305,0.755705490462038,0.315004782124789,-5.89146840359483,0.315050171214008,"SLCO1A2","solute carrier organic anion transporter family member 1A2",TRUE
+"210366_at",0.748924337581408,0.242091475047384,1.20189962273452,-5.25956514012279,0.722156501001039,"SLCO1B1","solute carrier organic anion transporter family member 1B1",TRUE
+"206354_at",0.0200497924453832,1.43016352148138e-05,5.53262047470143,3.06857942088346,5.37765138459353,"SLCO1B3","solute carrier organic anion transporter family member 1B3",TRUE
+"241951_at",0.805465456817488,0.344773110782449,0.965381811286516,-5.49567586388293,0.359667669009546,"SLCO1C1","solute carrier organic anion transporter family member 1C1",TRUE
+"220460_at",0.953931868692178,0.787493211544699,0.27285290343418,-5.90348717370566,0.154993118749345,"SLCO1C1","solute carrier organic anion transporter family member 1C1",TRUE
+"204368_at",0.526253358601247,0.0396349670273538,2.18634833321144,-3.84628216463823,1.29184555247678,"SLCO2A1","solute carrier organic anion transporter family member 2A1",TRUE
+"203473_at",0.817915083386752,0.370937766943903,0.913258476223567,-5.5414179344749,0.483079150583563,"SLCO2B1","solute carrier organic anion transporter family member 2B1",TRUE
+"211557_x_at",0.885929137203218,0.548045892764446,0.610033385422763,-5.76003497987725,0.404739912835279,"SLCO2B1","solute carrier organic anion transporter family member 2B1",TRUE
+"203472_s_at",0.90966932842395,0.624374692335548,0.496582208716074,-5.82028518522699,0.387330653255667,"SLCO2B1","solute carrier organic anion transporter family member 2B1",TRUE
+"227367_at",0.197114136379983,0.00216311809470489,3.46909670074892,-1.33619163407821,1.90931432540198,"SLCO3A1","solute carrier organic anion transporter family member 3A1",TRUE
+"229776_at",0.26392932766945,0.0040066089065504,3.21046624596782,-1.87719027348445,2.1209530968242,"SLCO3A1","solute carrier organic anion transporter family member 3A1",TRUE
+"219229_at",0.366786580319314,0.0108610420399994,2.78058004746764,-2.7452516525105,3.02494347600122,"SLCO3A1","solute carrier organic anion transporter family member 3A1",TRUE
+"210542_s_at",0.54295328972902,0.0459625934612453,2.1143966066034,-3.96922976639805,1.18066899570671,"SLCO3A1","solute carrier organic anion transporter family member 3A1",TRUE
+"229239_x_at",0.657571067962164,0.126236870628141,-1.58896600446838,-4.7795046986353,-1.11809346537382,"SLCO4A1","solute carrier organic anion transporter family member 4A1",TRUE
+"219911_s_at",0.774230543658252,0.288897550075054,1.08659171447685,-5.3804185002477,1.01731091741293,"SLCO4A1","solute carrier organic anion transporter family member 4A1",TRUE
+"1554332_a_at",0.673582826047901,0.139778352087215,1.53158875217023,-4.85749481547325,0.651488611173337,"SLCO4A1-AS1","SLCO4A1 antisense RNA 1",TRUE
+"207596_at",0.736094223891156,0.221313386405864,1.25849317486776,-5.19637678960508,0.649468511498315,"SLCO4C1","solute carrier organic anion transporter family member 4C1",TRUE
+"222071_s_at",0.785440072877511,0.310969276792114,-1.0368950282323,-5.42916009263573,-1.17527173491468,"SLCO4C1","solute carrier organic anion transporter family member 4C1",TRUE
+"230650_at",0.603702127972549,0.0783111088039214,-1.84590158545457,-4.40377680552733,-1.6834917411754,"SLCO5A1","solute carrier organic anion transporter family member 5A1",TRUE
+"220984_s_at",0.897375964261386,0.583805763118107,0.555965495691485,-5.79024451893091,0.424412644418654,"SLCO5A1","solute carrier organic anion transporter family member 5A1",TRUE
+"1552745_at",0.968980656821882,0.85349079000021,-0.186834241756697,-5.92269583924945,-0.0884677173944404,"SLCO6A1","solute carrier organic anion transporter family member 6A1",TRUE
+"223542_at",0.936599157163462,0.716908309496008,-0.367261788594417,-5.87420049332199,-0.153057597559698,"SLF1","SMC5-SMC6 complex localization factor 1",TRUE
+"1558076_at",0.951102506952277,0.77666940161304,-0.287145243919219,-5.89960356238807,-0.113113763056798,"SLF1","SMC5-SMC6 complex localization factor 1",TRUE
+"1553909_x_at",0.765889357241662,0.266075785608923,1.14094370007254,-5.32478907518052,0.857786801380641,"SLF2","SMC5-SMC6 complex localization factor 2",TRUE
+"203481_at",0.779001584485216,0.300131108864766,1.06097258529631,-5.40580064798727,0.415603725168461,"SLF2","SMC5-SMC6 complex localization factor 2",TRUE
+"203482_at",0.831943055644609,0.407961343386305,0.84350384267408,-5.59895606074285,0.356940185053723,"SLF2","SMC5-SMC6 complex localization factor 2",TRUE
+"235590_at",0.855280328719381,0.467725319226511,-0.738897234446593,-5.67720426367509,-0.550579924228289,"SLF2","SMC5-SMC6 complex localization factor 2",TRUE
+"226743_at",0.442366253594105,0.0205284312381976,2.49502352896245,-3.29170098171725,2.70958988433004,"SLFN11","schlafen family member 11",TRUE
+"219885_at",0.627861734840005,0.0992285670713604,1.7207752264309,-4.59200009667869,2.39545860042633,"SLFN12","schlafen family member 12",TRUE
+"1558217_at",0.655235030401569,0.123941025867853,1.59919547268006,-4.76536453106008,2.40080220630546,"SLFN13","schlafen family member 13",TRUE
+"1553423_a_at",0.707145212264574,0.178741129406585,1.38865315227879,-5.04171192501614,2.29252430303997,"SLFN13","schlafen family member 13",TRUE
+"243999_at",0.55092834440121,0.0492375952715097,2.08059978629132,-4.02607692542575,1.62186191945391,"SLFN5","schlafen family member 5",TRUE
+"226725_at",0.606339206711271,0.0800032614924738,1.83476746513453,-4.42091263010892,2.12001155405572,"SLFN5","schlafen family member 5",TRUE
+"238430_x_at",0.622917527985155,0.093496404496392,1.75261664840073,-4.54502116679559,1.81072576184422,"SLFN5","schlafen family member 5",TRUE
+"1553055_a_at",0.627053909308516,0.0977671169102892,1.72874101417439,-4.58030737720269,2.80301964484512,"SLFN5","schlafen family member 5",TRUE
+"230383_x_at",0.636860247875294,0.107926134211232,1.67533321581775,-4.6579270213616,1.47321909477716,"SLFN5","schlafen family member 5",TRUE
+"1557078_at",0.680972290639028,0.148939943424845,1.49531598794908,-4.90562251113812,1.99936477169857,"SLFN5","schlafen family member 5",TRUE
+"1553315_at",0.682825347106105,0.151027157336621,1.48730836077148,-4.91612264124645,0.850139115811949,"SLFNL1","schlafen like 1",TRUE
+"1554074_s_at",0.76711764189372,0.26902427823517,1.13373470957224,-5.33230561927261,0.722247416090569,"SLFNL1","schlafen like 1",TRUE
+"232671_at",0.957390359236635,0.807069877800225,0.247147343044154,-5.90997649724961,0.113210548906108,"SLFNL1-AS1","SLFNL1 antisense RNA 1",TRUE
+"221434_s_at",0.812302873476553,0.359245341864576,-0.936235194876897,-5.52154144062094,-0.336752620836162,"SLIRP","SRA stem-loop interacting RNA binding protein",TRUE
+"208221_s_at",0.6708432030569,0.136608894874581,-1.54459229312008,-4.84001805237202,-1.0671024532905,"SLIT1","slit guidance ligand 1",TRUE
+"213601_at",0.868397087637799,0.503499047837312,0.68007899507,-5.71688952104624,0.190518008381628,"SLIT1","slit guidance ligand 1",TRUE
+"231485_at",0.82943007322906,0.400675026870159,0.856897378030479,-5.58823772551118,0.460339876420049,"SLIT1-AS1","SLIT1 antisense RNA 1",TRUE
+"228850_s_at",0.897699110987203,0.585062185185305,0.554096854304261,-5.79124004323265,0.881194558226579,"SLIT2","slit guidance ligand 2",TRUE
+"230130_at",0.907830501915195,0.617353521195136,0.506725067487846,-5.81538808292602,0.666610204602732,"SLIT2","slit guidance ligand 2",TRUE
+"209897_s_at",0.949217179291784,0.770826790439036,0.294885406081614,-5.89741826142341,0.340817062444418,"SLIT2","slit guidance ligand 2",TRUE
+"241432_at",0.774230543658252,0.286843162206346,1.09135398978872,-5.37564071028709,0.599381529019538,"SLIT2-IT1","SLIT2 intronic transcript 1",TRUE
+"216216_at",0.515810181619652,0.036164126702354,-2.23036651695844,-3.76981647978921,-1.56591475386189,"SLIT3","slit guidance ligand 3",TRUE
+"203812_at",0.704331267592907,0.176216991336866,1.39710895044691,-5.03122487840387,1.04535404033886,"SLIT3","slit guidance ligand 3",TRUE
+"203813_s_at",0.976335130930535,0.88570188042764,0.145410014670106,-5.9293902270515,0.163977518901928,"SLIT3","slit guidance ligand 3",TRUE
+"236734_at",0.99886461451188,0.994941809257024,-0.0064114583099544,-5.93966345916339,-0.00530657187258887,"SLITRK1","SLIT and NTRK like family member 1",TRUE
+"233051_at",0.937257436560633,0.721677294402893,-0.360784860541613,-5.87648265941197,-0.209452594747304,"SLITRK2","SLIT and NTRK like family member 2",TRUE
+"206732_at",0.755868740464627,0.25040503852612,1.18028122868676,-5.28303672185207,0.800526943784486,"SLITRK3","SLIT and NTRK like family member 3",TRUE
+"232636_at",0.70939075283402,0.182403267398943,-1.37655223095255,-5.05662792194694,-1.94289942626724,"SLITRK4","SLIT and NTRK like family member 4",TRUE
+"230680_at",0.827866702343255,0.397246475951218,-0.863253726424802,-5.58309595408931,-1.04623481544688,"SLITRK4","SLIT and NTRK like family member 4",TRUE
+"214930_at",0.789224993491684,0.315434955580077,-1.02714669382013,-5.43848034356632,-1.24763275395658,"SLITRK5","SLIT and NTRK like family member 5",TRUE
+"215469_at",0.926263798296325,0.679736358110236,-0.4183249821872,-5.85480705267465,-0.369220774345616,"SLITRK5","SLIT and NTRK like family member 5",TRUE
+"235976_at",0.871993217850148,0.514631498008021,0.662265038932456,-5.72828853548683,1.05596896785076,"SLITRK6","SLIT and NTRK like family member 6",TRUE
+"232176_at",0.894692956611947,0.571486639154113,0.574395203589664,-5.78025194277495,0.85733296763096,"SLITRK6","SLIT and NTRK like family member 6",TRUE
+"232481_s_at",0.998038817582822,0.991052458886714,-0.0113415377804979,-5.93962082977942,-0.0168959387329615,"SLITRK6","SLIT and NTRK like family member 6",TRUE
+"206874_s_at",0.45894822559666,0.0229068021205258,2.44467762904845,-3.38493529221375,1.36124377635634,"SLK","STE20 like kinase",TRUE
+"206875_s_at",0.603702127972549,0.0779804447054238,1.8481016992714,-4.40038199901587,0.680469677375863,"SLK","STE20 like kinase",TRUE
+"1562095_at",0.682125064335234,0.149627210694333,1.49266923195441,-4.90909812698605,1.05857512072871,"SLMAP","sarcolemma associated protein",TRUE
+"222924_at",0.932091525948902,0.700264001005516,-0.38999510067848,-5.86587333653267,-0.24059220634406,"SLMAP","sarcolemma associated protein",TRUE
+"224149_x_at",0.934081042629428,0.708483600143436,0.378743119257383,-5.8700565416787,0.125758115016634,"SLMAP","sarcolemma associated protein",TRUE
+"225243_s_at",0.93966695059112,0.729391227857104,-0.350341350198679,-5.88007798765845,-0.10690857764612,"SLMAP","sarcolemma associated protein",TRUE
+"205374_at",0.993952584307899,0.97163816811748,-0.0359575910576638,-5.93905375289763,-0.022104587642648,"SLN","sarcolipin",TRUE
+"203021_at",0.6122079201328,0.0837807741708203,1.81063106873609,-4.45780383842948,2.37935951869306,"SLPI","secretory leukocyte peptidase inhibitor",TRUE
+"217828_at",0.751464513744428,0.244554834280137,-1.19543670204907,-5.266620943152,-0.406226957624337,"SLTM","SAFB like transcription modulator",TRUE
+"227990_at",0.728671251879936,0.210157666755952,-1.29057184991298,-5.15945414034029,-0.425859116783903,"SLU7","SLU7 homolog, splicing factor",TRUE
+"231718_at",0.992376456171815,0.9645611747799,0.0449356008538968,-5.93870004672547,0.0141251822151496,"SLU7","SLU7 homolog, splicing factor",TRUE
+"214536_at",0.776074974591224,0.29353514229711,-1.07593023344005,-5.39104711954391,-0.427288053502462,"SLURP1","secreted LY6/PLAUR domain containing 1",TRUE
+"222094_at",0.942671206410999,0.742799935423844,0.332281280866777,-5.88604904390531,0.187326734955231,"SLX1A-SULT1A3///SLX1A///SULT1A4///SLX1B///SULT1A3","SLX1A-SULT1A3 readthrough (NMD candidate)///SLX1 homolog A, structure-specific endonuclease subunit///sulfotransferase family 1A member 4///SLX1 homolog B, structure-specific endonuclease subunit///sulfotransferase family 1A member 3",TRUE
+"218317_x_at",0.693851377449481,0.163178582276564,-1.44239613198297,-4.97416853127885,-0.601800702468475,"SLX1A///SLX1B","SLX1 homolog A, structure-specific endonuclease subunit///SLX1 homolog B, structure-specific endonuclease subunit",TRUE
+"233334_x_at",0.679041081350052,0.146584266105739,-1.50446430858924,-4.8935712562243,-0.566810397793065,"SLX1B-SULT1A4///SLX1A-SULT1A3///SLX1A///SULT1A4///SLX1B///SULT1A3","SLX1B-SULT1A4 readthrough (NMD candidate)///SLX1A-SULT1A3 readthrough (NMD candidate)///SLX1 homolog A, structure-specific endonuclease subunit///sulfotransferase family 1A member 4///SLX1 homolog B, structure-specific endonuclease subunit///sulfotransferase family 1A member 3",TRUE
+"209607_x_at",0.770807031642694,0.279166236990419,-1.10937115655776,-5.35739672818297,-0.579610225743174,"SLX1B-SULT1A4///SLX1A-SULT1A3///SULT1A4///SULT1A3","SLX1B-SULT1A4 readthrough (NMD candidate)///SLX1A-SULT1A3 readthrough (NMD candidate)///sulfotransferase family 1A member 4///sulfotransferase family 1A member 3",TRUE
+"210580_x_at",0.805156059006033,0.344368275013205,-0.966208973527533,-5.49493123119574,-0.446567120074382,"SLX1B-SULT1A4///SLX1A-SULT1A3///SULT1A4///SULT1A3","SLX1B-SULT1A4 readthrough (NMD candidate)///SLX1A-SULT1A3 readthrough (NMD candidate)///sulfotransferase family 1A member 4///sulfotransferase family 1A member 3",TRUE
+"232147_at",0.933815609540291,0.706752787723195,-0.381108280712032,-5.86918725621354,-0.200079048826511,"SLX4","SLX4 structure-specific endonuclease subunit",TRUE
+"239687_at",0.989524702314661,0.948659155139954,-0.0651241771220362,-5.93761797994866,-0.0202253275776272,"SLX4","SLX4 structure-specific endonuclease subunit",TRUE
+"236390_at",0.606900628956089,0.080692869313809,-1.83028852743688,-4.42778495856507,-1.61118581044857,"SLX4IP","SLX4 interacting protein",TRUE
+"229615_at",0.756207119282867,0.251124350931162,-1.17843611561857,-5.28502279234084,-0.646581583771406,"SLX4IP","SLX4 interacting protein",TRUE
+"214850_at",0.774230543658252,0.289765271551461,-1.08458757742715,-5.38242359711773,-0.638881726059213,"SMA4","glucuronidase beta pseudogene",TRUE
+"206565_x_at",0.832605695407954,0.409171320135909,-0.841294512475716,-5.60070896571323,-0.586023043326795,"SMA4","glucuronidase beta pseudogene",TRUE
+"208015_at",0.846615322073696,0.445082288127206,0.777507690890793,-5.64945772349303,0.686804938150697,"SMAD1","SMAD family member 1",TRUE
+"227798_at",0.870363294479609,0.508623276121042,-0.671852176860796,-5.72218979351962,-0.288343714264258,"SMAD1","SMAD family member 1",TRUE
+"210993_s_at",0.972309558036541,0.866664072324765,-0.169856843501376,-5.92564081543117,-0.0699785951606948,"SMAD1","SMAD family member 1",TRUE
+"244446_at",0.722192678020526,0.198575800484932,-1.32530153114594,-5.11859159010294,-0.792629908410726,"SMAD1-AS2","SMAD1 antisense RNA 2",TRUE
+"203075_at",0.646392036827936,0.117428697348296,-1.62909846901914,-4.72362667232088,-0.5773634824025,"SMAD2","SMAD family member 2",TRUE
+"235598_at",0.778295711796067,0.297923199856971,-1.0659530627003,-5.40090867073661,-0.835880327273984,"SMAD2","SMAD family member 2",TRUE
+"203077_s_at",0.898336157829132,0.587494133665206,-0.550485536378523,-5.79315476209337,-0.189389937729249,"SMAD2","SMAD family member 2",TRUE
+"203076_s_at",0.966593471043185,0.844704604801271,0.19818866296244,-5.92057033986371,0.0571682313537742,"SMAD2","SMAD family member 2",TRUE
+"226563_at",0.969882914559333,0.856399290635129,0.183081180297565,-5.92337092310907,0.0677546293707287,"SMAD2","SMAD family member 2",TRUE
+"239271_at",0.997763494670794,0.989050260840493,-0.0138795970293537,-5.93958965177797,-0.00680740847663852,"SMAD2","SMAD family member 2",TRUE
+"205397_x_at",0.550258486810386,0.0487609029464348,2.08539121790601,-4.01805347633113,2.40527195075176,"SMAD3","SMAD family member 3",TRUE
+"205398_s_at",0.62110896023334,0.091672245621682,1.76310042772558,-4.52941412428413,1.16177005401411,"SMAD3","SMAD family member 3",TRUE
+"205396_at",0.707694888507328,0.179199056375443,1.38712930082965,-5.04359623104951,0.643044540881482,"SMAD3","SMAD family member 3",TRUE
+"218284_at",0.765400039004994,0.265674658257646,1.14192897775124,-5.32375850146581,0.591908301189783,"SMAD3","SMAD family member 3",TRUE
+"1565702_at",0.645213368083975,0.116433695605283,1.63378890815469,-4.71702576123411,1.11662636398357,"SMAD4","SMAD family member 4",TRUE
+"202527_s_at",0.726636642789909,0.206313311367103,-1.30193099836571,-5.14619021391492,-0.508752031608854,"SMAD4","SMAD family member 4",TRUE
+"202526_at",0.772116141939407,0.282452582623321,-1.10161496414198,-5.36528311098145,-0.512058335158503,"SMAD4","SMAD family member 4",TRUE
+"235725_at",0.89390639630277,0.569699777030063,-0.577085005733333,-5.77876712996985,-0.191494191825354,"SMAD4","SMAD family member 4",TRUE
+"1565703_at",0.943345639021508,0.745855847957867,-0.328181239323571,-5.88736107495443,-0.108049248192803,"SMAD4","SMAD family member 4",TRUE
+"235451_at",0.884749233889577,0.544271852057547,-0.615845225869989,-5.75662663142278,-0.158491879225235,"SMAD5","SMAD family member 5",TRUE
+"225223_at",0.893172664248402,0.567502100727587,-0.580399123539013,-5.77692844924346,-0.160056566593699,"SMAD5","SMAD family member 5",TRUE
+"205187_at",0.952041062962677,0.7806592732737,-0.281869853358612,-5.90105993345352,-0.0880546177548283,"SMAD5","SMAD family member 5",TRUE
+"205188_s_at",0.978276691813018,0.895334499592597,-0.133076013360132,-5.93106164928532,-0.0473562287145874,"SMAD5","SMAD family member 5",TRUE
+"225219_at",0.982909728377256,0.916915047012609,0.105516985448014,-5.93426205518029,0.039844455413494,"SMAD5","SMAD family member 5",TRUE
+"220263_at",0.996898592071515,0.984012418543131,-0.0202662012139726,-5.93948343669027,-0.0125321517410324,"SMAD5-AS1","SMAD5 antisense RNA 1",TRUE
+"213565_s_at",0.531252719138635,0.0416743102402488,-2.16209025648068,-3.88802056226493,-1.25877853755467,"SMAD6","SMAD family member 6",TRUE
+"209887_at",0.872668627020452,0.516347408330898,0.659538463776654,-5.73000767092979,0.511425675860272,"SMAD6","SMAD family member 6",TRUE
+"209886_s_at",0.906507435035949,0.614297718121969,-0.511156328421915,-5.81321829513763,-0.30841436441789,"SMAD6","SMAD family member 6",TRUE
+"207069_s_at",0.954577684533304,0.792260424637035,-0.26657656634984,-5.90513043097393,-0.195538739666906,"SMAD6","SMAD family member 6",TRUE
+"204790_at",0.774011928861764,0.285698620368289,-1.09401783218463,-5.37296007328261,-0.618976553877729,"SMAD7","SMAD family member 7",TRUE
+"206320_s_at",0.702185342714694,0.173651100009697,1.40580411126159,-5.02038614809624,0.620290888884977,"SMAD9","SMAD family member 9",TRUE
+"227719_at",0.817889575750373,0.370761754561344,0.913600753598452,-5.54112517891805,0.741596354340478,"SMAD9","SMAD family member 9",TRUE
+"209679_s_at",0.966532288376818,0.843798686734285,-0.199360875856127,-5.9203437937521,-0.0991357362874066,"SMAGP","small cell adhesion glycoprotein",TRUE
+"218137_s_at",0.929088231432081,0.687313892421505,0.407828003244972,-5.85899644068594,0.136568050115107,"SMAP1","small ArfGAP 1",TRUE
+"225282_at",0.596382916302699,0.0729362702127545,-1.88271328421521,-4.34659909886473,-0.801956633432539,"SMAP2","small ArfGAP2",TRUE
+"203874_s_at",0.597654932724127,0.0742305234410918,1.87363797850279,-4.36076938743453,2.03975041073317,"SMARCA1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1",TRUE
+"203875_at",0.623667408398064,0.0952152387627307,1.74289741953048,-4.55942864743585,2.66832250309398,"SMARCA1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1",TRUE
+"215294_s_at",0.637349652490244,0.108189156374247,1.67400809623509,-4.65982950299358,3.29030155581337,"SMARCA1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1",TRUE
+"203873_at",0.827060995001753,0.395807770689782,0.865931534346206,-5.5809192394899,0.45869281224302,"SMARCA1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1",TRUE
+"206542_s_at",0.752913428584105,0.246242632430972,-1.19103670697655,-5.27140563504791,-0.60254935937064,"SMARCA2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2",TRUE
+"206543_at",0.796174477255647,0.328373729784566,0.999436918800566,-5.46453833379137,0.659416691247078,"SMARCA2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2",TRUE
+"212258_s_at",0.820701713129222,0.381613162375568,-0.892696458360828,-5.55881902508283,-0.681557478544629,"SMARCA2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2",TRUE
+"217707_x_at",0.826974115143008,0.395268670343525,-0.866936559491132,-5.58010066475622,-0.437955578157483,"SMARCA2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2",TRUE
+"212257_s_at",0.838999550222784,0.424544647367382,-0.81357680873099,-5.62233493540437,-0.442899528773681,"SMARCA2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2",TRUE
+"206544_x_at",0.875399854304381,0.522726190092902,-0.649446287583682,-5.73631169643341,-0.349244222890334,"SMARCA2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2",TRUE
+"228926_s_at",0.937113154905832,0.719612024268213,-0.363587830740146,-5.875499944689,-0.250169463404308,"SMARCA2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2",TRUE
+"1569073_x_at",0.703902004301726,0.175438818938407,1.39973525429813,-5.02795697696782,0.450379700037638,"SMARCA4","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",TRUE
+"212520_s_at",0.7569746234637,0.252625486163362,1.17459819980155,-5.28914520804804,0.431274387447232,"SMARCA4","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",TRUE
+"214728_x_at",0.768852835478002,0.273656895448602,1.12252422359458,-5.34391077679721,0.409309556241972,"SMARCA4","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",TRUE
+"208794_s_at",0.813442508625161,0.363982768660931,0.926866383616438,-5.52970100524524,0.337565059945126,"SMARCA4","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",TRUE
+"214360_at",0.863719378931144,0.489158757405972,0.703357435623509,-5.70155817706557,0.389043565191313,"SMARCA4","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",TRUE
+"208793_x_at",0.867972140419125,0.501443508625193,0.683392368430966,-5.71473739576034,0.273624796599428,"SMARCA4","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",TRUE
+"213719_s_at",0.893600768892136,0.568879752165743,0.578320846329692,-5.77808267448538,0.429647628294042,"SMARCA4","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",TRUE
+"215714_s_at",0.907964244160782,0.618043004840085,0.505726660982141,-5.81587441358594,0.184270054126301,"SMARCA4","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",TRUE
+"213720_s_at",0.933400538871064,0.705296279615115,0.383100320402123,-5.86845096717369,0.146365535108199,"SMARCA4","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",TRUE
+"213859_x_at",0.829044392052913,0.400279848051606,-0.8576282304,-5.5876483252099,-0.300617071355363,"SMARCA5","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5",TRUE
+"213251_at",0.916107385524794,0.646310199942348,-0.465225272142322,-5.834812473663,-0.181621946712891,"SMARCA5","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5",TRUE
+"202303_x_at",0.998870448604467,0.995080373287063,-0.00623582046798034,-5.93966454109448,-0.00195397996415103,"SMARCA5","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5",TRUE
+"223197_s_at",0.981944022360435,0.91346617761667,0.109915116313709,-5.93380082161491,0.0334648433510747,"SMARCAD1","SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1",TRUE
+"218452_at",0.423498495208141,0.0178384459892885,-2.55898045335459,-3.1718367726155,-0.782511926076003,"SMARCAL1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1",TRUE
+"206532_at",0.855405088766616,0.468335886609965,0.737871750629458,-5.67792295745958,0.635539269659739,"SMARCB1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1",TRUE
+"212167_s_at",0.866611803190887,0.497887699347639,-0.68914227893783,-5.71097895074229,-0.198573943119403,"SMARCB1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1",TRUE
+"228898_s_at",0.980808506518944,0.909860218575964,0.114515951563246,-5.93329819985881,0.0671934942763723,"SMARCB1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1",TRUE
+"201072_s_at",0.868301026121579,0.502473013697893,0.681731926630952,-5.71581714747355,0.276704153324275,"SMARCC1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1",TRUE
+"201073_s_at",0.898076623395524,0.586956928402664,0.551282620102574,-5.79273319424997,0.203888171126799,"SMARCC1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1",TRUE
+"201074_at",0.90998880119877,0.625398821094123,-0.495107169384391,-5.82098930191535,-0.186489867146502,"SMARCC1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1",TRUE
+"201075_s_at",0.949503174041699,0.771880522663583,0.293488098789275,-5.8978170309546,0.103950777855452,"SMARCC1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1",TRUE
+"1561973_at",0.811030057997891,0.355043519674065,0.944614466375494,-5.51417985945391,0.325194959390349,"SMARCC2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2",TRUE
+"201320_at",0.835952408568777,0.416360792385644,-0.828251799960201,-5.61096962775108,-0.258454318810998,"SMARCC2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2",TRUE
+"201321_s_at",0.953983577550391,0.78783544044947,0.272401967314339,-5.9036065028289,0.0825670890961199,"SMARCC2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2",TRUE
+"209518_at",0.565043084457947,0.0562989172846292,-2.01409083398459,-4.13619969283081,-0.620704738389986,"SMARCD1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1",TRUE
+"203183_s_at",0.998495910561622,0.993674640870021,0.00801767709820757,-5.93965217084725,0.00209406882363439,"SMARCD1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1",TRUE
+"201827_at",0.870857065562116,0.510702846920909,-0.668526750446664,-5.72431473328838,-0.403685979779773,"SMARCD2","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2",TRUE
+"204099_at",0.821745015752602,0.384562004322865,-0.887083474997886,-5.56350544030493,-0.705656543795337,"SMARCD3","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3",TRUE
+"231144_at",0.875823460099203,0.523780073128921,-0.647785426536832,-5.73734020370113,-0.255625069857004,"SMARCD3","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3",TRUE
+"236016_at",0.512681169570718,0.0342818956462615,-2.25587244217976,-3.72508832040282,-1.42652804092881,"SMARCE1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1",TRUE
+"229511_at",0.882562076266907,0.540229484342837,-0.62209408227152,-5.75292724526333,-0.310081854773566,"SMARCE1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1",TRUE
+"211989_at",0.927552865877291,0.682556277568568,-0.414413091628173,-5.85638054502665,-0.173443820333617,"SMARCE1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1",TRUE
+"211988_at",0.952107104988926,0.780945500326171,-0.2814917208813,-5.90116329485,-0.105450906508825,"SMARCE1","SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1",TRUE
+"201589_at",0.748438284778152,0.241212135459255,-1.20421864630587,-5.25702532038105,-0.330352364848361,"SMC1A","structural maintenance of chromosomes 1A",TRUE
+"239688_at",0.861659105448003,0.483021484399011,0.713439582483246,-5.69476534197148,0.242790399964871,"SMC1A","structural maintenance of chromosomes 1A",TRUE
+"1555677_s_at",0.941161916043887,0.73634291578652,-0.340963741693439,-5.88321742656886,-0.22396715247529,"SMC1A","structural maintenance of chromosomes 1A",TRUE
+"217555_at",0.985498770484702,0.929744925766114,-0.0891738197740086,-5.9358111113427,-0.0307794186235109,"SMC1A","structural maintenance of chromosomes 1A",TRUE
+"1553249_at",0.630603891142543,0.101600875456099,1.70805512936597,-4.61058784233886,1.34440693958363,"SMC1B","structural maintenance of chromosomes 1B",TRUE
+"204240_s_at",0.871744769522775,0.513885566089603,0.6634518961286,-5.72753808543304,0.263432208943446,"SMC2","structural maintenance of chromosomes 2",TRUE
+"213253_at",0.994098505325585,0.97288785849848,0.0343725459842907,-5.93910804572251,0.0146176308591581,"SMC2","structural maintenance of chromosomes 2",TRUE
+"1556925_at",0.446963972064621,0.021173053272014,2.48086298230009,-3.31802636398361,1.58002690895181,"SMC3","structural maintenance of chromosomes 3",TRUE
+"209258_s_at",0.633098477100746,0.104412786322965,1.69330110721167,-4.63201808823514,0.635619301657467,"SMC3","structural maintenance of chromosomes 3",TRUE
+"209257_s_at",0.686051458768383,0.154323568052532,1.47484322560421,-4.93237733281327,0.562390344818393,"SMC3","structural maintenance of chromosomes 3",TRUE
+"209259_s_at",0.796872917873374,0.329723932712379,0.996589372336967,-5.46717953136918,0.340934063063784,"SMC3","structural maintenance of chromosomes 3",TRUE
+"215623_x_at",0.535243600695458,0.042636067506218,2.15102076215465,-3.90697033468434,1.16678618540755,"SMC4","structural maintenance of chromosomes 4",TRUE
+"201663_s_at",0.553930058946379,0.0505759988026608,2.06736577875508,-4.04817565216453,0.790193592861456,"SMC4","structural maintenance of chromosomes 4",TRUE
+"201664_at",0.600874588084954,0.0766877526411853,1.85678144019803,-4.38696098303105,0.599893641833715,"SMC4","structural maintenance of chromosomes 4",TRUE
+"237725_x_at",0.560923390313819,0.0545574820544875,2.02977007969471,-4.11045095756833,1.33320810382329,"SMC5","structural maintenance of chromosomes 5",TRUE
+"212927_at",0.73957587762701,0.227914801050766,-1.24009065927575,-5.21719862579129,-0.49971674729993,"SMC5","structural maintenance of chromosomes 5",TRUE
+"212926_at",0.875604460253057,0.523103554432235,-0.648851371424694,-5.7366803957518,-0.22173615635899,"SMC5","structural maintenance of chromosomes 5",TRUE
+"1557693_at",0.813970831648786,0.36490805404256,0.925046064426794,-5.53127761506449,0.300791680240724,"SMC5-AS1","SMC5 antisense RNA 1 (head to head)",TRUE
+"218781_at",0.737123149977386,0.222895650504917,1.25404453024799,-5.20143441297577,0.398015502061899,"SMC6","structural maintenance of chromosomes 6",TRUE
+"236535_at",0.755049574909504,0.249050501250437,-1.18376652803477,-5.27927776223132,-0.758722908735943,"SMC6","structural maintenance of chromosomes 6",TRUE
+"1558747_at",0.473893167318731,0.0259330289276203,2.38720617447676,-3.49010452110061,1.10405453100808,"SMCHD1","structural maintenance of chromosomes flexible hinge domain containing 1",TRUE
+"212569_at",0.606138724709726,0.0797370714114254,1.83650531381228,-4.41824289676001,0.943958348307063,"SMCHD1","structural maintenance of chromosomes flexible hinge domain containing 1",TRUE
+"212577_at",0.626609324441886,0.0971860461137118,1.73193646386309,-4.57560558525282,0.920589531108543,"SMCHD1","structural maintenance of chromosomes flexible hinge domain containing 1",TRUE
+"241620_at",0.657799846742042,0.126482849360752,1.58787922015024,-4.78100280131465,1.39235316590229,"SMCHD1","structural maintenance of chromosomes flexible hinge domain containing 1",TRUE
+"212579_at",0.73223722457785,0.216166413744481,1.27313502135067,-5.179622388251,0.759635411680067,"SMCHD1","structural maintenance of chromosomes flexible hinge domain containing 1",TRUE
+"241621_at",0.986342822130003,0.934214914897102,0.0834858575306745,-5.93628927518615,0.0677243157018732,"SMCHD1","structural maintenance of chromosomes flexible hinge domain containing 1",TRUE
+"1559429_a_at",0.772430642757484,0.282866900080969,1.10064177567214,-5.36626916377254,0.794040541709482,"SMCO1","single-pass membrane protein with coiled-coil domains 1",TRUE
+"237484_at",0.527546822913581,0.0400782315187058,2.1809810814873,-3.85554187457987,0.876211593344867,"SMCO3","single-pass membrane protein with coiled-coil domains 3",TRUE
+"219806_s_at",0.955904644595647,0.800382472904954,0.255908372615738,-5.90783639985854,0.132737989099141,"SMCO4","single-pass membrane protein with coiled-coil domains 4",TRUE
+"206406_at",0.844988171233814,0.442052065144962,-0.782764151370146,-5.64557710805747,-0.254694232001335,"SMCP","sperm mitochondria associated cysteine rich protein",TRUE
+"1553020_at",0.89967769475675,0.591100280841871,0.545144168913418,-5.79596445676707,0.216852250131748,"SMCR5","Smith-Magenis syndrome chromosome region, candidate 5 (non-protein coding)",TRUE
+"227304_at",0.744573608322482,0.235948465254601,1.21823497728972,-5.24158412530801,0.421723195410266,"SMCR8","Smith-Magenis syndrome chromosome region, candidate 8",TRUE
+"1552484_at",0.786221214160608,0.311599649684974,1.03551300988862,-5.43048624972169,0.56846034440953,"SMCR8","Smith-Magenis syndrome chromosome region, candidate 8",TRUE
+"238434_at",0.813021318305036,0.362218242569342,0.930346339061027,-5.52667902058365,0.268781924787744,"SMCR8","Smith-Magenis syndrome chromosome region, candidate 8",TRUE
+"1557986_s_at",0.846321019035727,0.444370967953758,0.778739635380104,-5.64855044459855,0.203885803589126,"SMCR8","Smith-Magenis syndrome chromosome region, candidate 8",TRUE
+"227305_s_at",0.928473211581075,0.68575409657187,0.409984905936374,-5.85814416111278,0.150063095956677,"SMCR8","Smith-Magenis syndrome chromosome region, candidate 8",TRUE
+"225794_s_at",0.695744345349551,0.165597676949134,-1.43377965738209,-4.98513911579765,-0.504474783971347,"SMDT1","single-pass membrane protein with aspartate rich tail 1",TRUE
+"225795_at",0.878081456012172,0.529884216912037,-0.638201380625263,-5.74322580488387,-0.278351077596088,"SMDT1","single-pass membrane protein with aspartate rich tail 1",TRUE
+"227648_at",0.915569510513076,0.644039059192638,0.468449467684022,-5.83336149455408,0.471351586393252,"SMDT1","single-pass membrane protein with aspartate rich tail 1",TRUE
+"238449_at",0.927041268353741,0.681379701510603,0.416044475914934,-5.85572611531295,0.199315005597176,"SMG1P5","SMG1P5, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 5",TRUE
+"210396_s_at",0.986844665519238,0.938508679890331,-0.0780247950516002,-5.93671873934509,-0.0318979021174925,"SMG1P5///BOLA2///SMG1P2","SMG1P5, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 5///bolA family member 2///SMG1P2, nonsense mediated mRNA decay associated PI3K related kinase pseudogene 2",TRUE
+"34868_at",0.834454640870101,0.412911613373639,-0.83449114328367,-5.60607985273893,-0.26305506526653,"SMG5","SMG5, nonsense mediated mRNA decay factor",TRUE
+"212147_at",0.864894115958506,0.493860377876725,-0.695682936576466,-5.70666707451738,-0.224276233512374,"SMG5","SMG5, nonsense mediated mRNA decay factor",TRUE
+"214940_s_at",0.585892284764425,0.0658729294450113,1.93488008746976,-4.2642201366854,1.30674610727996,"SMG6","SMG6, nonsense mediated mRNA decay factor",TRUE
+"220347_at",0.89085645983207,0.55989724367924,0.591918470746372,-5.77045825101329,0.230035102245707,"SMG6","SMG6, nonsense mediated mRNA decay factor",TRUE
+"217189_s_at",0.812302873476553,0.360668711664572,0.933411658315532,-5.52400847974701,0.317561542658389,"SMG7","SMG7, nonsense mediated mRNA decay factor",TRUE
+"242575_at",0.812569243022409,0.361216194817735,0.932327607521329,-5.52495383995538,0.556140136353496,"SMG7","SMG7, nonsense mediated mRNA decay factor",TRUE
+"236367_at",0.837368340567858,0.421161550244551,0.819621540217491,-5.61767654189815,0.269568045067293,"SMG7","SMG7, nonsense mediated mRNA decay factor",TRUE
+"201793_x_at",0.958587459575795,0.812233761846173,0.240395784897516,-5.91157517056122,0.0977077495376752,"SMG7","SMG7, nonsense mediated mRNA decay factor",TRUE
+"201794_s_at",0.983364220761052,0.918989540360094,-0.10287254401546,-5.93453032255714,-0.0334588056638552,"SMG7","SMG7, nonsense mediated mRNA decay factor",TRUE
+"222384_at",0.808257777979515,0.350885200075735,-0.952973108801158,-5.50677648987257,-0.58358381266927,"SMG7-AS1","SMG7 antisense RNA 1",TRUE
+"215953_at",0.948567563026335,0.766016534660017,-0.301271738813053,-5.89557179694351,-0.18104817398681,"SMG7-AS1","SMG7 antisense RNA 1",TRUE
+"218514_at",0.774230543658252,0.289731884697268,-1.0846646095672,-5.38234658909468,-0.576700277937102,"SMG8","SMG8, nonsense mediated mRNA decay factor",TRUE
+"223188_at",0.620754085170559,0.0904176391995249,-1.77041532279309,-4.51848403861975,-0.786745101159344,"SMG9","SMG9, nonsense mediated mRNA decay factor",TRUE
+"233990_at",0.71454754703986,0.189630499644441,1.35322459503807,-5.08507555443163,0.518110007665121,"SMG9","SMG9, nonsense mediated mRNA decay factor",TRUE
+"221335_x_at",0.76912869907427,0.275071961874735,-1.11912758649526,-5.34740686073816,-0.412223345674061,"SMG9","SMG9, nonsense mediated mRNA decay factor",TRUE
+"230840_at",0.976371465776674,0.886579995684991,0.144284712026743,-5.92954884641083,0.123827717970432,"SMIM1","small integral membrane protein 1 (Vel blood group)",TRUE
+"227976_at",0.498538741392062,0.031254411176807,2.29971381536477,-3.64750298754706,2.00270450875895,"SMIM10","small integral membrane protein 10",TRUE
+"238915_at",0.751464513744428,0.24443512657077,1.19574963711651,-5.26628006293157,0.874766371039856,"SMIM10L1","small integral membrane protein 10 like 1",TRUE
+"221847_at",0.774230543658252,0.290055956188992,1.08391716221912,-5.38309359643586,0.463836531817584,"SMIM10L1","small integral membrane protein 10 like 1",TRUE
+"237386_at",0.797963285726587,0.332108871451873,-0.991579243765541,-5.47180997971228,-0.378816813291627,"SMIM10L1","small integral membrane protein 10 like 1",TRUE
+"238697_at",0.609045683857105,0.0815085813110104,-1.82503322968817,-4.43583314438305,-1.79601678737591,"SMIM10L2A","small integral membrane protein 10 like 2A",TRUE
+"227909_at",0.925091998149497,0.675648148424697,-0.424008119423881,-5.85249521171121,-0.274959129993929,"SMIM10L2B///SMIM10L2A","small integral membrane protein 10 like 2B///small integral membrane protein 10 like 2A",TRUE
+"1554432_x_at",0.818637718131529,0.372178834194704,0.910848122584638,-5.54347668452356,0.232923918398852,"SMIM11A","small integral membrane protein 11A",TRUE
+"1554430_at",0.896458677219354,0.581040360460299,-0.560085473714942,-5.78803809718272,-0.157011018691132,"SMIM11A","small integral membrane protein 11A",TRUE
+"228239_at",0.987915939622712,0.942263650534406,0.0732510007063782,-5.93707037956713,0.034587971268925,"SMIM11A","small integral membrane protein 11A",TRUE
+"238640_at",0.517654151778308,0.0367729791348219,-2.22237463306777,-3.7837683252821,-1.00532769505957,"SMIM12","small integral membrane protein 12",TRUE
+"225404_at",0.692289844352812,0.161869837589508,-1.44710066768016,-4.96815604032958,-0.337024701025564,"SMIM12","small integral membrane protein 12",TRUE
+"235707_at",0.584828007864693,0.0650356314465693,1.94138621326913,-4.25383686542728,0.888037557711847,"SMIM13","small integral membrane protein 13",TRUE
+"1564651_at",0.627885807511309,0.0992444288708319,1.72068932050371,-4.59212597570007,0.894275326240056,"SMIM13","small integral membrane protein 13",TRUE
+"227124_at",0.637485146909712,0.108823652879022,1.67082264610957,-4.66439819876664,0.79654323816245,"SMIM13","small integral membrane protein 13",TRUE
+"227052_at",0.740476003158683,0.229749845157287,-1.23504746526457,-5.22285876634389,-1.1143414064371,"SMIM14","small integral membrane protein 14",TRUE
+"224990_at",0.767011398042819,0.268483241007596,-1.13505316965361,-5.33093405025691,-0.932829337011118,"SMIM14","small integral membrane protein 14",TRUE
+"224989_at",0.789488409459128,0.316274159292099,-1.02532560249874,-5.4402126579383,-1.0307993044734,"SMIM14","small integral membrane protein 14",TRUE
+"243634_at",0.7994347047598,0.33473311696321,-0.986095021022546,-5.47685426772634,-0.725533806094297,"SMIM14","small integral membrane protein 14",TRUE
+"222336_at",0.98665814592247,0.937753828127319,-0.0789846789006365,-5.93664535544264,-0.0620031119983482,"SMIM14","small integral membrane protein 14",TRUE
+"224740_at",0.942303845415102,0.740795817448722,-0.334973308920847,-5.88517881820277,-0.0961137757828716,"SMIM15","small integral membrane protein 15",TRUE
+"1557430_at",0.997466539876354,0.987173699846554,-0.0162584786802576,-5.93955473221264,-0.0176914600797242,"SMIM17","small integral membrane protein 17",TRUE
+"225534_at",0.679582597949812,0.146842709768956,-1.50345479730454,-4.89490399642229,-0.694355604925047,"SMIM19","small integral membrane protein 19",TRUE
+"220930_s_at",0.6287528932499,0.0998574949757291,1.7173779500911,-4.59697459145458,1.04358091431281,"SMIM2","small integral membrane protein 2",TRUE
+"220931_at",0.776936981479994,0.295345854535565,1.07180035027982,-5.39513911185993,0.503214756980503,"SMIM2","small integral membrane protein 2",TRUE
+"238113_at",0.768882610729436,0.274223880532959,1.12116173186376,-5.34531428579908,0.787649561058201,"SMIM2-AS1","SMIM2 antisense RNA 1",TRUE
+"225014_at",0.896229101808264,0.579643337295819,0.562170526248907,-5.78691544073849,0.485837173568441,"SMIM20","small integral membrane protein 20",TRUE
+"1564400_at",0.79943091106207,0.334326556177987,-0.986942718102105,-5.47607623421798,-0.715318859152788,"SMIM21","small integral membrane protein 21",TRUE
+"1556288_at",0.956619372543067,0.803108444465518,-0.252334702079896,-5.90871830370894,-0.147627850354519,"SMIM21","small integral membrane protein 21",TRUE
+"229599_at",0.884221189678062,0.543095488695803,-0.617661137745196,-5.75555530323428,-0.71921507752094,"SMIM22","small integral membrane protein 22",TRUE
+"231982_at",0.474859593446097,0.0261316014442481,2.3836556276548,-3.49655649284849,0.813179548841358,"SMIM24","small integral membrane protein 24",TRUE
+"223276_at",0.998038817582822,0.990994653121656,0.0114148133234736,-5.93962001761452,0.00664422814732646,"SMIM3","small integral membrane protein 3",TRUE
+"223900_s_at",0.592488489935347,0.0695781970925143,1.90693439455368,-4.30854524057371,1.04598097251874,"SMIM4","small integral membrane protein 4",TRUE
+"229826_at",0.634202341398092,0.105280363904935,-1.68881706237312,-4.63850343479414,-0.92458757337521,"SMIM4","small integral membrane protein 4",TRUE
+"238207_at",0.683019114815084,0.15217081766228,-1.48295884784564,-4.92180698907018,-0.802236713928108,"SMIM4","small integral membrane protein 4",TRUE
+"223399_x_at",0.740321726337106,0.228922216443953,1.23731820292197,-5.22031270257349,0.771708674274381,"SMIM4","small integral membrane protein 4",TRUE
+"223899_at",0.888312537451395,0.55414839061726,0.600680332312544,-5.76545458697273,0.255223860881991,"SMIM4","small integral membrane protein 4",TRUE
+"229740_at",0.805335305758344,0.344636361305761,-0.965661144312862,-5.49542446627117,-0.590381387434902,"SMIM5","small integral membrane protein 5",TRUE
+"236098_at",0.705559553212919,0.177306633058818,1.39344693117696,-5.03577305049627,0.841864358852948,"SMIM6","small integral membrane protein 6",TRUE
+"224717_s_at",0.823753503658162,0.390942037730626,-0.875034846268429,-5.57347256012804,-0.281554507079422,"SMIM7","small integral membrane protein 7",TRUE
+"1559382_at",0.933859583363678,0.707064542973438,0.380682102941453,-5.8693442866793,0.146682064915486,"SMIM7","small integral membrane protein 7",TRUE
+"221988_at",0.948668195792872,0.766488619964998,0.300644413143049,-5.89575491111582,0.118462240401129,"SMIM7","small integral membrane protein 7",TRUE
+"229650_s_at",0.98353485756265,0.919656809474768,-0.102022109451241,-5.93461515014792,-0.0369854548210444,"SMIM7","small integral membrane protein 7",TRUE
+"219097_x_at",0.986342822130003,0.933195713401232,-0.0847825136116138,-5.93618304097721,-0.0261765890742947,"SMIM7","small integral membrane protein 7",TRUE
+"224712_x_at",0.995111934465262,0.977537646568563,0.0284757455945793,-5.93928854451771,0.00896396212191775,"SMIM7","small integral membrane protein 7",TRUE
+"236178_at",0.816022845943054,0.367010400230039,-0.92092152793165,-5.53483938946651,-0.286400560667468,"SMIM8","small integral membrane protein 8",TRUE
+"213314_at",0.819018525257656,0.374215268778792,0.906904545087693,-5.54683417471856,0.259754826360304,"SMIM8","small integral membrane protein 8",TRUE
+"213312_at",0.861659105448003,0.482922150104954,0.713603374326491,-5.69465422741495,0.417558238222471,"SMIM8","small integral membrane protein 8",TRUE
+"235736_at",0.99739139970986,0.986693000845386,-0.0168678668198932,-5.93954490009569,-0.0113022007957291,"SMKR1","small lysine rich protein 1",TRUE
+"244151_at",0.84665840154298,0.445124750843219,-0.777434187146741,-5.64951181329639,-0.536668468160757,"SMLR1","small leucine rich protein 1",TRUE
+"230716_at",0.846758911329672,0.445234004295887,0.777245087045323,-5.6496509457738,0.404310766975586,"SMLR1","small leucine rich protein 1",TRUE
+"203852_s_at",0.592007267652348,0.0690967140052687,-1.91049082915816,-4.30292915678145,-0.615815255014585,"SMN2///SMN1","survival of motor neuron 2, centromeric///survival of motor neuron 1, telomeric",TRUE
+"200071_at",0.85334340854827,0.46160467040893,0.749221435576272,-5.66991600253352,0.23481104496555,"SMNDC1","survival motor neuron domain containing 1",TRUE
+"217345_at",0.969882914559333,0.85732860101788,-0.181882589527074,-5.92358364362376,-0.115935306983056,"SMNP","survival of motor neuron 1, telomeric pseudogene",TRUE
+"218629_at",0.612420348961838,0.0839535526075996,1.80954980962713,-4.45944824625354,1.51057185453256,"SMO","smoothened, frizzled class receptor",TRUE
+"222784_at",0.11175913050536,0.00056211725448512,4.0242169515118,-0.14844770425705,2.72905890782445,"SMOC1","SPARC related modular calcium binding 1",TRUE
+"222783_s_at",0.268558783291603,0.00413512331031919,3.19709930229217,-1.90482992078244,2.55109126525121,"SMOC1","SPARC related modular calcium binding 1",TRUE
+"243946_at",0.789927874973432,0.319073127097005,1.01927616050121,-5.44594725809405,0.338089331561076,"SMOC2","SPARC related modular calcium binding 2",TRUE
+"223235_s_at",0.979950968379024,0.904260072603217,0.121666226047369,-5.93247621655646,0.177528694038516,"SMOC2","SPARC related modular calcium binding 2",TRUE
+"1555680_a_at",0.353309890338186,0.00940549176222926,2.84374069927343,-2.6207625174238,3.18453931710562,"SMOX","spermine oxidase",TRUE
+"210357_s_at",0.459387394115312,0.0230050788310512,2.44270350092622,-3.38857040716705,2.12298894443436,"SMOX","spermine oxidase",TRUE
+"217074_at",0.711977799428804,0.185835992770117,1.36538294805778,-5.07029922543382,0.473240202457558,"SMOX","spermine oxidase",TRUE
+"216571_at",0.710672261019989,0.183893520164164,1.37168304302098,-5.06259924648243,0.607253014082835,"SMPD1","sphingomyelin phosphodiesterase 1",TRUE
+"217171_at",0.755868740464627,0.250409443500561,-1.18026991743038,-5.28304890549828,-0.943592216056015,"SMPD1","sphingomyelin phosphodiesterase 1",TRUE
+"209420_s_at",0.767965891104819,0.270970430772003,-1.12900812469297,-5.33721102935862,-0.526750972313254,"SMPD1","sphingomyelin phosphodiesterase 1",TRUE
+"216230_x_at",0.927444355549168,0.682178366762969,-0.414936959842952,-5.85617067096129,-0.236011402712252,"SMPD1","sphingomyelin phosphodiesterase 1",TRUE
+"205622_at",0.963737076458538,0.834474661604591,0.211442640239248,-5.91793129745947,0.067989555845303,"SMPD2","sphingomyelin phosphodiesterase 2",TRUE
+"219695_at",0.279325273101419,0.00451237347192087,-3.16006572446921,-1.98121903505112,-2.27201649422276,"SMPD3","sphingomyelin phosphodiesterase 3",TRUE
+"231732_at",0.980561931836093,0.909164219423902,-0.115404263796618,-5.93319878495696,-0.0556371858571163,"SMPD3","sphingomyelin phosphodiesterase 3",TRUE
+"213624_at",0.815217400146643,0.366244046639951,-0.922423187111858,-5.53354431700881,-1.19596730910215,"SMPDL3A","sphingomyelin phosphodiesterase acid like 3A",TRUE
+"1562512_at",0.89205696974366,0.562455882738525,0.588033857689683,-5.772653908703,0.491330948276753,"SMPDL3A","sphingomyelin phosphodiesterase acid like 3A",TRUE
+"205309_at",0.902242032847473,0.600979613466448,0.530592248254634,-5.80348399876146,0.621680419231994,"SMPDL3B","sphingomyelin phosphodiesterase acid like 3B",TRUE
+"1554050_at",0.923790792577188,0.672649084108496,-0.428186240315571,-5.85077604144505,-0.139031717811093,"SMPDL3B","sphingomyelin phosphodiesterase acid like 3B",TRUE
+"219772_s_at",0.751464513744428,0.244473810512964,1.19564849854246,-5.2663902416871,0.926654961823738,"SMPX","small muscle protein, X-linked",TRUE
+"214566_at",0.908822913900964,0.62137390338264,0.500910659332342,-5.8182071745639,0.440855328645077,"SMR3A","submaxillary gland androgen regulated protein 3A",TRUE
+"214565_s_at",0.899808883319249,0.593168253935863,0.542088351036292,-5.79755992292954,0.306895996048468,"SMR3A///SMR3B","submaxillary gland androgen regulated protein 3A///submaxillary gland androgen regulated protein 3B",TRUE
+"207441_at",0.978045498886343,0.893666155159834,0.135210662239096,-5.93078295102425,0.101304855348549,"SMR3B","submaxillary gland androgen regulated protein 3B",TRUE
+"202043_s_at",0.984925919649162,0.92583073428041,0.0941570117778983,-5.93536632402119,0.0334882864014059,"SMS","spermine synthase",TRUE
+"209427_at",0.716472449896956,0.192437252733129,-1.34435392382414,-5.09578653761368,-0.616836250536975,"SMTN","smoothelin",TRUE
+"207390_s_at",0.943294768503521,0.745050005463075,-0.329261858254558,-5.88701683662173,-0.177971898826497,"SMTN","smoothelin",TRUE
+"1556030_at",0.953983577550391,0.788678084417616,0.271291907584514,-5.90389941776864,0.0866667385149684,"SMTN","smoothelin",TRUE
+"230367_at",0.943824539742785,0.748582583252368,0.324527686648073,-5.88851664336555,0.236191206207559,"SMTNL1","smoothelin like 1",TRUE
+"229730_at",0.876309093376839,0.525021971996597,-0.64583061221831,-5.73854750473044,-0.581755119566459,"SMTNL2","smoothelin like 2",TRUE
+"233946_at",0.620130575154958,0.0898976669168395,-1.77347257764608,-4.5139059854337,-1.11617594407464,"SMU1","DNA replication regulator and spliceosomal factor",TRUE
+"218393_s_at",0.873301865850313,0.518297266481761,0.656446233371803,-5.73194912564551,0.220453254285834,"SMU1","DNA replication regulator and spliceosomal factor",TRUE
+"222618_at",0.898609426925686,0.588166694967561,-0.549488124770882,-5.79368144646907,-0.238157486234952,"SMU1","DNA replication regulator and spliceosomal factor",TRUE
+"218685_s_at",0.690330257199992,0.15991531594677,-1.45418403865071,-4.95907328748922,-0.55520037841808,"SMUG1","single-strand-selective monofunctional uracil-DNA glycosylase 1",TRUE
+"223684_s_at",0.812302873476553,0.359524978817991,-0.935679887500399,-5.52202717611132,-0.285586141476067,"SMUG1","single-strand-selective monofunctional uracil-DNA glycosylase 1",TRUE
+"234708_at",0.978356576329994,0.895944154780428,0.132296117243879,-5.93116236771086,0.0395535811844283,"SMUG1","single-strand-selective monofunctional uracil-DNA glycosylase 1",TRUE
+"215458_s_at",0.606910676285326,0.0807549185180749,1.82988715444009,-4.42840022377884,0.739828208131637,"SMURF1","SMAD specific E3 ubiquitin protein ligase 1",TRUE
+"212668_at",0.627092759817312,0.098919025032069,1.72245402367818,-4.58953919318628,1.06883766727575,"SMURF1","SMAD specific E3 ubiquitin protein ligase 1",TRUE
+"212666_at",0.632216562924782,0.103217280731588,1.69953212881813,-4.62298456315959,0.738086079374368,"SMURF1","SMAD specific E3 ubiquitin protein ligase 1",TRUE
+"232665_x_at",0.64030781048631,0.110968569958433,1.66016913880324,-4.67962980473745,0.663224625402514,"SMURF1","SMAD specific E3 ubiquitin protein ligase 1",TRUE
+"1559426_at",0.933815609540291,0.706753062886153,-0.381107904525225,-5.86918739490061,-0.134003768748522,"SMURF1","SMAD specific E3 ubiquitin protein ligase 1",TRUE
+"230820_at",0.55937703282623,0.0536163865925044,2.03842987693225,-4.09617306183472,1.5254392227867,"SMURF2","SMAD specific E3 ubiquitin protein ligase 2",TRUE
+"205596_s_at",0.677013732819214,0.144532195096888,1.51253203025337,-4.88289467009963,0.898326929393335,"SMURF2","SMAD specific E3 ubiquitin protein ligase 2",TRUE
+"232020_at",0.740476003158683,0.229602442180306,1.23545143418536,-5.22240611104406,0.672881982858609,"SMURF2","SMAD specific E3 ubiquitin protein ligase 2",TRUE
+"227489_at",0.839466826665106,0.42566208392966,0.811586854488396,-5.62386142494974,0.436078424804142,"SMURF2","SMAD specific E3 ubiquitin protein ligase 2",TRUE
+"243045_at",0.817916967564753,0.371007610881851,0.913122686097114,-5.5415340500055,0.61250976553226,"SMYD1","SET and MYND domain containing 1",TRUE
+"228406_at",0.900019475989605,0.594630151461774,-0.539931270924394,-5.79868090219432,-0.299453266192464,"SMYD1","SET and MYND domain containing 1",TRUE
+"212922_s_at",0.901781358899845,0.599030216622201,0.533454377904849,-5.80202065781292,0.202109876702885,"SMYD2","SET and MYND domain containing 2",TRUE
+"243288_at",0.912244494826693,0.632213277151627,0.48532049601487,-5.82560918077254,0.240797826315416,"SMYD2","SET and MYND domain containing 2",TRUE
+"212921_at",0.919354071504066,0.656763360296089,0.450449259066006,-5.8413364766662,0.364483297742998,"SMYD2","SET and MYND domain containing 2",TRUE
+"218788_s_at",0.759576632581869,0.257159021404548,-1.16310949583317,-5.30141520145505,-0.578895171732754,"SMYD3","SET and MYND domain containing 3",TRUE
+"229175_at",0.555180272174837,0.0513782139547631,2.0595830670956,-4.06112871735466,0.74503969119961,"SMYD4","SET and MYND domain containing 4",TRUE
+"209516_at",0.950931310281113,0.775999032133145,0.288032416378942,-5.89935601003178,0.0785159218842857,"SMYD5","SMYD family member 5",TRUE
+"219480_at",0.954448216024374,0.790703830723805,-0.268624705470117,-5.90459836546016,-0.198758244808739,"SNAI1","snail family transcriptional repressor 1",TRUE
+"213139_at",0.526634268561088,0.0397891712637107,2.18447501341616,-3.84951565534104,4.00751987744517,"SNAI2","snail family transcriptional repressor 2",TRUE
+"1560228_at",0.965992617204023,0.841064182588046,-0.202900929248131,-5.91965155210087,-0.161202797335473,"SNAI3","snail family transcriptional repressor 3",TRUE
+"1556154_a_at",0.931370027472813,0.696660960655915,0.394943495110567,-5.86399544146242,0.211368093367153,"SNAI3-AS1","SNAI3 antisense RNA 1",TRUE
+"1568683_at",0.93474377881867,0.710167233891347,0.376444536750752,-5.870896242719,0.256585546100484,"SNAI3-AS1","SNAI3 antisense RNA 1",TRUE
+"229773_at",0.740610299769501,0.230490420915043,1.23302083774486,-5.22512771723077,0.787478211414327,"SNAP23","synaptosome associated protein 23",TRUE
+"214544_s_at",0.839519981963042,0.42690272761269,0.809381304618422,-5.62554919912661,0.351633157626484,"SNAP23","synaptosome associated protein 23",TRUE
+"209131_s_at",0.894729774938685,0.571811154741652,0.573907162695106,-5.78052062882405,0.28673812522964,"SNAP23","synaptosome associated protein 23",TRUE
+"209130_at",0.968663599207376,0.85253026783464,0.18807427791996,-5.92246978644306,0.0774757017174341,"SNAP23","synaptosome associated protein 23",TRUE
+"202507_s_at",0.826140850652187,0.394316350732333,0.86871410066077,-5.57865072843022,0.313880523049105,"SNAP25","synaptosome associated protein 25",TRUE
+"1556629_a_at",0.955892698633978,0.799937976289753,0.256491416754939,-5.90769134791298,0.173859882443445,"SNAP25","synaptosome associated protein 25",TRUE
+"202508_s_at",0.961539013416204,0.825658066212644,-0.222896552204384,-5.91551371563127,-0.187619086966662,"SNAP25","synaptosome associated protein 25",TRUE
+"222597_at",0.55937703282623,0.0537221900966244,-2.0374495593631,-4.09779137973185,-0.989248248219589,"SNAP29","synaptosome associated protein 29",TRUE
+"218327_s_at",0.592584559127425,0.0696930908659983,-1.90608893291048,-4.3098792658539,-0.682781263704312,"SNAP29","synaptosome associated protein 29",TRUE
+"239084_at",0.643688366500038,0.114446884027936,-1.64325633946431,-4.70365773850184,-0.785796128055427,"SNAP29","synaptosome associated protein 29",TRUE
+"225244_at",0.820293495506061,0.379368013719907,-0.896989091941327,-5.55521653889147,-0.268474803992964,"SNAP47","synaptosome associated protein 47",TRUE
+"204953_at",0.979588787486838,0.902482413076624,0.123937285270986,-5.93220473977509,0.0947798930829067,"SNAP91","synaptosome associated protein 91",TRUE
+"205443_at",0.956398858120188,0.802292898832193,-0.253403504837347,-5.9084558384034,-0.142823143927187,"SNAPC1","small nuclear RNA activating complex polypeptide 1",TRUE
+"204104_at",0.919354071504066,0.656358573609167,0.451019530569526,-5.84108851579806,0.178816718114705,"SNAPC2","small nuclear RNA activating complex polypeptide 2",TRUE
+"204001_at",0.766550448794594,0.267767329712679,-1.13680078365942,-5.32911387327131,-0.619529827335363,"SNAPC3","small nuclear RNA activating complex polypeptide 3",TRUE
+"210465_s_at",0.806221445484273,0.346909400813255,-0.961027859344975,-5.49958579496845,-0.534993354456992,"SNAPC3","small nuclear RNA activating complex polypeptide 3",TRUE
+"229712_at",0.983783029912313,0.920736326503024,-0.10064642779535,-5.93475087976461,-0.0537293787228608,"SNAPC3","small nuclear RNA activating complex polypeptide 3",TRUE
+"222286_at",0.99783553534859,0.989811506407667,0.0129146043076708,-5.93960224527512,0.00637584053040197,"SNAPC3","small nuclear RNA activating complex polypeptide 3",TRUE
+"205658_s_at",0.79871392967667,0.333221328242532,-0.989250763515475,-5.47395478139102,-0.272893859694632,"SNAPC4","small nuclear RNA activating complex polypeptide 4",TRUE
+"215926_x_at",0.819780516863333,0.377516093196637,-0.900542474726924,-5.55222235901418,-0.449471123802329,"SNAPC4","small nuclear RNA activating complex polypeptide 4",TRUE
+"213203_at",0.587626678796111,0.0666665647744749,-1.92878011282559,-4.27393342381852,-0.558696765437784,"SNAPC5","small nuclear RNA activating complex polypeptide 5",TRUE
+"1554093_a_at",0.79943091106207,0.334334988256052,-0.986925129639256,-5.47609238344419,-0.307624496699203,"SNAPC5","small nuclear RNA activating complex polypeptide 5",TRUE
+"214592_s_at",0.915353407558177,0.642635981704441,-0.470443847635589,-5.8324590559006,-0.22662921989544,"SNAPC5","small nuclear RNA activating complex polypeptide 5",TRUE
+"223066_at",0.663569501512357,0.131548785128348,-1.56587821785966,-4.81115803499958,-0.473910584573348,"SNAPIN","SNAP associated protein",TRUE
+"204467_s_at",0.238716647597999,0.00313061980075114,3.31448915779606,-1.66094439595379,1.84310261070449,"SNCA","synuclein alpha",TRUE
+"204466_s_at",0.299994279961527,0.00557614003636226,3.06982465160025,-2.16613950912561,2.96060968744179,"SNCA","synuclein alpha",TRUE
+"211546_x_at",0.485152361954952,0.027924279085925,2.352682778391,-3.55261097465,1.21276419737535,"SNCA","synuclein alpha",TRUE
+"236081_at",0.552420073963858,0.0499980408703854,2.073041619514,-4.03870909122613,1.59300993319022,"SNCA","synuclein alpha",TRUE
+"207827_x_at",0.689130495692328,0.158092196979231,1.46085453273526,-4.95048700489184,1.04196700804595,"SNCA","synuclein alpha",TRUE
+"237833_s_at",0.684251725941042,0.153107190034983,1.47941743869746,-4.92642531962851,0.67044527894788,"SNCAIP","synuclein alpha interacting protein",TRUE
+"219511_s_at",0.714590421965913,0.189884216317631,1.35241849915016,-5.08605131802064,0.558596720411188,"SNCAIP","synuclein alpha interacting protein",TRUE
+"237834_at",0.947938416246738,0.76307955049845,-0.305177304331596,-5.89442326649227,-0.265054717951645,"SNCAIP","synuclein alpha interacting protein",TRUE
+"207853_s_at",0.896907177224677,0.581911119803503,0.558787137110385,-5.78873511688329,0.394222650168113,"SNCB","synuclein beta",TRUE
+"209877_at",0.73223722457785,0.216380177619732,1.2725216151609,-5.18032762204056,1.70152803746982,"SNCG","synuclein gamma",TRUE
+"208584_at",0.818285672675087,0.371375229661812,0.912408243426208,-5.54214471492533,0.447607085968326,"SNCG","synuclein gamma",TRUE
+"201622_at",0.682504456039784,0.149949618607766,1.49143101139066,-4.91072241048892,0.419155924050793,"SND1","staphylococcal nuclease and tudor domain containing 1",TRUE
+"210109_at",0.809930331505913,0.353516795707728,0.947675609535117,-5.5114754981521,0.582255804283446,"SND1-IT1","SND1 intronic transcript 1",TRUE
+"213488_at",0.39259320496653,0.0133526614384941,-2.68909921380589,-2.92336355212535,-2.29077050850938,"SNED1","sushi, nidogen and EGF like domains 1",TRUE
+"1559421_at",0.606312240108248,0.0799341789857647,-1.83521799423434,-4.42022068795527,-0.641835975894322,"SNED1","sushi, nidogen and EGF like domains 1",TRUE
+"213493_at",0.830635993561085,0.404446808051826,-0.849944912105547,-5.59382116969123,-0.844702799178328,"SNED1","sushi, nidogen and EGF like domains 1",TRUE
+"1554798_at",0.949216032237554,0.770709598886543,0.295040845563443,-5.89737378534702,0.211619588816252,"SNED1","sushi, nidogen and EGF like domains 1",TRUE
+"218391_at",0.620223198657182,0.0899836937646207,-1.7729657219433,-4.51466537115412,-0.89777110173681,"SNF8","SNF8, ESCRT-II complex subunit",TRUE
+"224610_at",0.896159990898752,0.578739063612469,0.563521495090627,-5.78618587743209,0.261883202976852,"SNHG1///SNORD22///SNORD25///SNORD26///SNORD27///SNORD28///SNORD30///SNORD31///SNORD29","small nucleolar RNA host gene 1///small nucleolar RNA, C/D box 22///small nucleolar RNA, C/D box 25///small nucleolar RNA, C/D box 26///small nucleolar RNA, C/D box 27///small nucleolar RNA, C/D box 28///small nucleolar RNA, C/D box 30///small nucleolar RNA, C/D box 31///small nucleolar RNA, C/D box 29",TRUE
+"229209_at",0.597654932724127,0.0742909713628582,1.87321750539775,-4.36142474974263,1.1649398304241,"SNHG10","small nucleolar RNA host gene 10",TRUE
+"224601_at",0.823074246722209,0.389591000419337,0.877575523261348,-5.57138132996845,0.396130956983908,"SNHG16///SNORD1C///SNORD1A","small nucleolar RNA host gene 16///small nucleolar RNA, C/D box 1C///small nucleolar RNA, C/D box 1A",TRUE
+"224603_at",0.878647293269438,0.531683455475482,0.6353878975204,-5.74493756453164,0.2652438143868,"SNHG16///SNORD1C///SNORD1A","small nucleolar RNA host gene 16///small nucleolar RNA, C/D box 1C///small nucleolar RNA, C/D box 1A",TRUE
+"225857_s_at",0.76029267756668,0.258765615145535,1.15907421643884,-5.30569981644553,0.510005919893528,"SNHG17","small nucleolar RNA host gene 17",TRUE
+"65588_at",0.808257777979515,0.350656409599377,0.953434941672022,-5.50636569616515,0.450232221867596,"SNHG17","small nucleolar RNA host gene 17",TRUE
+"1568249_at",0.874790223742073,0.521306174119144,0.651687064283245,-5.73492006328384,0.432653207185091,"SNHG17///SNORA71B","small nucleolar RNA host gene 17///small nucleolar RNA, H/ACA box 71B",TRUE
+"227655_at",0.83766047465051,0.422185439846809,0.817788912538896,-5.6190922772666,0.929967051939588,"SNHG18","small nucleolar RNA host gene 18",TRUE
+"228049_x_at",0.606900628956089,0.0805743721373872,-1.83105578575953,-4.42660855801833,-1.04773308449926,"SNHG19","small nucleolar RNA host gene 19",TRUE
+"240006_at",0.951934441578502,0.780197207036182,0.282480374310752,-5.90089275872434,0.114088850166112,"SNHG22","small nucleolar RNA host gene 22",TRUE
+"242856_at",0.635368778245437,0.106487277624952,1.68263099260663,-4.64742913562086,1.019476992117,"SNHG24","small nucleolar RNA host gene 24",TRUE
+"215011_at",0.910165867297668,0.626632511468426,0.493331778240327,-5.82183407993333,0.211079653423308,"SNHG3///SNORA73A","small nucleolar RNA host gene 3///small nucleolar RNA, H/ACA box 73A",TRUE
+"1564911_at",0.64660365025697,0.117529896227778,1.62862328745638,-4.7242945861775,0.961891142535094,"SNHG4","small nucleolar RNA host gene 4",TRUE
+"1564907_s_at",0.528056136690037,0.0406315897037949,2.17435574137873,-3.86695266404923,1.90397760128488,"SNHG4///MATR3","small nucleolar RNA host gene 4///matrin 3",TRUE
+"200626_s_at",0.664923327339077,0.132534694491838,-1.56167840799695,-4.81687688540337,-0.326352221993858,"SNHG4///MATR3","small nucleolar RNA host gene 4///matrin 3",TRUE
+"1564906_at",0.67450217874052,0.14091974493344,1.52696527247164,-4.86368050310969,1.05050053827353,"SNHG4///MATR3","small nucleolar RNA host gene 4///matrin 3",TRUE
+"1558093_s_at",0.73957587762701,0.227746624558679,-1.24055439743357,-5.21667716031414,-0.380452787437136,"SNHG4///MATR3","small nucleolar RNA host gene 4///matrin 3",TRUE
+"200624_s_at",0.781368538085109,0.303058092704761,-1.05441013592717,-5.41221511521178,-0.238263192924721,"SNHG4///MATR3","small nucleolar RNA host gene 4///matrin 3",TRUE
+"238993_at",0.897560972979555,0.584420231880794,0.555051363887086,-5.79073193187714,0.438649528333734,"SNHG4///MATR3","small nucleolar RNA host gene 4///matrin 3",TRUE
+"1565325_at",0.912722788750542,0.633896385722717,0.482910698011593,-5.82673291404797,0.370481492129483,"SNHG4///MATR3","small nucleolar RNA host gene 4///matrin 3",TRUE
+"228012_at",0.930899509890345,0.694231479105318,-0.398285797619079,-5.86271385511108,-0.149220425145589,"SNHG4///MATR3","small nucleolar RNA host gene 4///matrin 3",TRUE
+"214363_s_at",0.976422537443518,0.887972481400212,-0.142500635291529,-5.9297978040804,-0.0293576306735233,"SNHG4///MATR3","small nucleolar RNA host gene 4///matrin 3",TRUE
+"225220_at",0.925504446660705,0.677277651560818,-0.421741209002594,-5.85342104363366,-0.188346859028456,"SNHG8///SNORA24","small nucleolar RNA host gene 8///small nucleolar RNA, H/ACA box 24",TRUE
+"228645_at",0.426884347674613,0.0183636394280876,-2.54581615512018,-3.19663536506991,-1.46578730282214,"SNHG9///SNORA78","small nucleolar RNA host gene 9///small nucleolar RNA, H/ACA box 78",TRUE
+"219409_at",0.722160153958635,0.198400871927072,-1.32583803622928,-5.11795315898673,-0.343176366521664,"SNIP1","Smad nuclear interacting protein 1",TRUE
+"235837_at",0.73612054366523,0.221441253981283,-1.25813276368923,-5.19678710927781,-0.396724088268674,"SNIP1","Smad nuclear interacting protein 1",TRUE
+"218032_at",0.233834817057915,0.00301318959572427,-3.33054462981533,-1.62739611859701,-1.49288490017179,"SNN","stannin",TRUE
+"218033_s_at",0.360736459722853,0.01030749306352,-2.8035942665345,-2.70002930372761,-1.19269306290542,"SNN","stannin",TRUE
+"223313_s_at",0.835289077598304,0.414468044851946,0.831671596251944,-5.60829378289693,1.40633828670655,"SNORA11E///SNORA11D///MAGED4///MAGED4B","small nucleolar RNA, H/ACA box 11E///small nucleolar RNA, H/ACA box 11D///MAGE family member D4///MAGE family member D4B",TRUE
+"221261_x_at",0.839466826665106,0.425793945312054,0.811352248168405,-5.62404115983371,0.958281006322188,"SNORA11E///SNORA11D///MAGED4///MAGED4B","small nucleolar RNA, H/ACA box 11E///small nucleolar RNA, H/ACA box 11D///MAGE family member D4///MAGE family member D4B",TRUE
+"223774_at",0.383328885347805,0.0122342735241321,2.72796844546521,-2.84801426966399,0.973582807046594,"SNORA16A///SNORA61///SNORA44///SNHG12","small nucleolar RNA, H/ACA box 16A///small nucleolar RNA, H/ACA box 61///small nucleolar RNA, H/ACA box 44///small nucleolar RNA host gene 12",TRUE
+"223773_s_at",0.52629147962869,0.0397039721223981,2.18550922312792,-3.84773074294701,0.713565499313191,"SNORA16A///SNORA61///SNORA44///SNHG12","small nucleolar RNA, H/ACA box 16A///small nucleolar RNA, H/ACA box 61///small nucleolar RNA, H/ACA box 44///small nucleolar RNA host gene 12",TRUE
+"228990_at",0.7994347047598,0.334727998607122,0.986105688610123,-5.47684448057845,0.52243734724769,"SNORA16A///SNORA61///SNORA44///SNHG12","small nucleolar RNA, H/ACA box 16A///small nucleolar RNA, H/ACA box 61///small nucleolar RNA, H/ACA box 44///small nucleolar RNA host gene 12",TRUE
+"1558619_at",0.984236975186631,0.922968374635688,-0.0978026468713388,-5.93502562133687,-0.057120196066407,"SNORA17B","small nucleolar RNA, H/ACA box 17B",TRUE
+"229050_s_at",0.588653540532996,0.0673683228836755,-1.92343931019981,-4.28242046441173,-1.00105779063522,"SNORA17B///SNORA17A///SNHG7","small nucleolar RNA, H/ACA box 17B///small nucleolar RNA, H/ACA box 17A///small nucleolar RNA host gene 7",TRUE
+"1552729_at",0.899242030026774,0.589610014347139,-0.547349574753287,-5.79480758311289,-0.214734693142025,"SNORA17B///SNORA17A///SNHG7","small nucleolar RNA, H/ACA box 17B///small nucleolar RNA, H/ACA box 17A///small nucleolar RNA host gene 7",TRUE
+"215224_at",0.702809964629668,0.174643137091945,1.40243027235659,-5.02459830823699,1.20219592695912,"SNORA21","small nucleolar RNA, H/ACA box 21",TRUE
+"200888_s_at",0.95719237049442,0.806247466637029,0.248223687063248,-5.90971756601063,0.0700602717613048,"SNORA21///RPL23","small nucleolar RNA, H/ACA box 21///ribosomal protein L23",TRUE
+"214744_s_at",0.974536463688956,0.875679788429685,-0.158267306196866,-5.92749061953957,-0.110879918494895,"SNORA21///RPL23","small nucleolar RNA, H/ACA box 21///ribosomal protein L23",TRUE
+"241843_at",0.986421906591669,0.936435181847786,-0.0806616775812166,-5.93651499566402,-0.0401116130285217,"SNORA28///EIF5","small nucleolar RNA, H/ACA box 28///eukaryotic translation initiation factor 5",TRUE
+"208778_s_at",0.769847953580141,0.27747139888724,1.11339713993292,-5.35328381279361,0.366510716456711,"SNORA29///TCP1","small nucleolar RNA, H/ACA box 29///t-complex 1",TRUE
+"222010_at",0.942502815705589,0.74157860610035,0.333921530053425,-5.88551964337076,0.106649659477457,"SNORA29///TCP1","small nucleolar RNA, H/ACA box 29///t-complex 1",TRUE
+"222011_s_at",0.98539961718117,0.928359264389935,0.0909376464132398,-5.93565643896434,0.0299292344534834,"SNORA29///TCP1","small nucleolar RNA, H/ACA box 29///t-complex 1",TRUE
+"236130_at",0.728262401376535,0.208561332718839,-1.29526892801975,-5.1539813890625,-0.753641157286872,"SNORA37","small nucleolar RNA, H/ACA box 37",TRUE
+"223707_at",0.976994788692278,0.890327172336736,0.139484838668877,-5.93021161128985,0.0638039597448596,"SNORA3A///RPL27A","small nucleolar RNA, H/ACA box 3A///ribosomal protein L27a",TRUE
+"203034_s_at",0.996261754016157,0.98148987246754,0.0234644063180574,-5.93941531788573,0.00504545448089644,"SNORA3A///RPL27A","small nucleolar RNA, H/ACA box 3A///ribosomal protein L27a",TRUE
+"200705_s_at",0.947778780715578,0.762287379641241,-0.306231550979356,-5.89411072562592,-0.0857689930420271,"SNORA41///EEF1B2","small nucleolar RNA, H/ACA box 41///eukaryotic translation elongation factor 1 beta 2",TRUE
+"200909_s_at",0.90415231543826,0.606418759350867,0.522629987512648,-5.80751460361059,0.143436264714293,"SNORA52///RPLP2","small nucleolar RNA, H/ACA box 52///ribosomal protein lateral stalk subunit P2",TRUE
+"220789_s_at",0.858400984062047,0.474161301986925,-0.728127073260692,-5.68470507442666,-0.246219917163259,"SNORA5B///TBRG4","small nucleolar RNA, H/ACA box 5B///transforming growth factor beta regulator 4",TRUE
+"226149_at",0.830592576740524,0.40302783604312,-0.852555587421722,-5.59172953720502,-0.341515375064983,"SNORA60///SNORA71E///SNHG11","small nucleolar RNA, H/ACA box 60///small nucleolar RNA, H/ACA box 71E///small nucleolar RNA host gene 11",TRUE
+"217466_x_at",0.712948021516228,0.187114936808343,-1.36126325447129,-5.07531834023826,-0.297990951393615,"SNORA64///RPS2","small nucleolar RNA, H/ACA box 64///ribosomal protein S2",TRUE
+"212433_x_at",0.979551619255899,0.901309933903409,-0.125435557537632,-5.93202289542369,-0.0269584765173168,"SNORA64///RPS2","small nucleolar RNA, H/ACA box 64///ribosomal protein S2",TRUE
+"203107_x_at",0.988948717228281,0.946552379694517,0.0678007512776392,-5.93744472786059,0.0154140734176913,"SNORA64///RPS2","small nucleolar RNA, H/ACA box 64///ribosomal protein S2",TRUE
+"1558081_at",0.896159990898752,0.578844845979933,0.563363403414075,-5.78627133937469,0.266554982067429,"SNORA65","small nucleolar RNA, H/ACA box 65",TRUE
+"210035_s_at",0.91269009113888,0.633719360666341,0.483164017718225,-5.8266150436183,0.418238325451592,"SNORA66///RPL5///SNORD21","small nucleolar RNA, H/ACA box 66///ribosomal protein L5///small nucleolar RNA, C/D box 21",TRUE
+"1566402_at",0.235343578627527,0.00304321737703999,3.32638192018083,-1.63609838288842,1.24170297202361,"SNORA68","small nucleolar RNA, H/ACA box 68",TRUE
+"200869_at",0.945498722604777,0.753650330508717,0.3177493205234,-5.89062662341069,0.0959061309900093,"SNORA68///RPL18A","small nucleolar RNA, H/ACA box 68///ribosomal protein L18a",TRUE
+"1566403_at",0.990810941805126,0.955523618066358,0.0564064268868834,-5.93813391810915,0.0403671437059963,"SNORA68///RPL18A","small nucleolar RNA, H/ACA box 68///ribosomal protein L18a",TRUE
+"217680_x_at",0.744307803443383,0.23514587389378,-1.22039284188098,-5.23919315372252,-0.555870703893684,"SNORA70///RPL10","small nucleolar RNA, H/ACA box 70///ribosomal protein L10",TRUE
+"221989_at",0.818598668505758,0.372041766158571,-0.911114068949189,-5.54324977871507,-0.374511611671938,"SNORA70///RPL10","small nucleolar RNA, H/ACA box 70///ribosomal protein L10",TRUE
+"200724_at",0.961899417580562,0.826995993090251,-0.22115648477152,-5.91588916843535,-0.101196655265566,"SNORA70///RPL10","small nucleolar RNA, H/ACA box 70///ribosomal protein L10",TRUE
+"200725_x_at",0.980676048578047,0.909557977565483,-0.114901693825596,-5.93325512400051,-0.0253894336596776,"SNORA70///RPL10","small nucleolar RNA, H/ACA box 70///ribosomal protein L10",TRUE
+"1565859_at",0.931370027472813,0.696538883929542,-0.395111329784723,-5.8639313399199,-0.311881050090211,"SNORA71A","small nucleolar RNA, H/ACA box 71A",TRUE
+"1565858_at",0.962741248200658,0.830415264316488,-0.216712640817849,-5.91683472158853,-0.146131460036322,"SNORA71A","small nucleolar RNA, H/ACA box 71A",TRUE
+"1568248_x_at",0.786455312223125,0.312241127541503,1.03410866634432,-5.43183219683205,0.476265135190709,"SNORA71B","small nucleolar RNA, H/ACA box 71B",TRUE
+"228047_at",0.46584896273628,0.0242407419194412,-2.41852766240039,-3.43295795370729,-0.84868577382198,"SNORA72","small nucleolar RNA, H/ACA box 72",TRUE
+"1567682_x_at",0.806221445484273,0.346905024700289,0.96103675957535,-5.49957781887285,0.681588089573395,"SNORA74A","small nucleolar RNA, H/ACA box 74A",TRUE
+"1567681_at",0.849935057946582,0.451900006742711,-0.765760239622157,-5.65804114944866,-0.556117434435314,"SNORA74A","small nucleolar RNA, H/ACA box 74A",TRUE
+"1567679_at",0.914588178928864,0.640432454788705,0.473579929202058,-5.83103241814891,0.390839037407614,"SNORA74A","small nucleolar RNA, H/ACA box 74A",TRUE
+"1558954_at",0.977369242833284,0.891653970640529,-0.137786112140336,-5.93044080934335,-0.0860325763852492,"SNORA78","small nucleolar RNA, H/ACA box 78",TRUE
+"214805_at",0.535243600695458,0.0426643041949114,2.15069918987223,-3.90751992183842,0.727880315266773,"SNORD10///SNORA48///SNORA67///EIF4A1","small nucleolar RNA, C/D box 10///small nucleolar RNA, H/ACA box 48///small nucleolar RNA, H/ACA box 67///eukaryotic translation initiation factor 4A1",TRUE
+"228879_at",0.897699110987203,0.585111659029563,-0.554023314081694,-5.79127915546473,-0.327133197599768,"SNORD104///SNORA50C","small nucleolar RNA, C/D box 104///small nucleolar RNA, H/ACA box 50C",TRUE
+"240083_at",0.854163696308241,0.463868322968888,0.745393711730366,-5.6726293240977,0.391214611331138,"SNORD112///MEG8","small nucleolar RNA, C/D box 112///maternally expressed 8 (non-protein coding)",TRUE
+"232355_at",0.982844899319041,0.916501232423504,-0.106044583423791,-5.93420771876513,-0.0833218824083723,"SNORD114-3","small nucleolar RNA, C/D box 114-3",TRUE
+"232976_at",0.828957581240848,0.399961609385159,0.858217124976303,-5.58717306720416,0.802021396286004,"SNORD116-21///SNORD116-20///SNORD116-17///SNORD116-19///SNORD116@","small nucleolar RNA, C/D box 116-21///small nucleolar RNA, C/D box 116-20///small nucleolar RNA, C/D box 116-17///small nucleolar RNA, C/D box 116-19///small nucleolar RNA, C/D box 116 cluster",TRUE
+"224187_x_at",0.928114879020015,0.684114453395256,-0.412254357524489,-5.85724263361757,-0.0890080442428758,"SNORD14D///SNORD14C///HSPA8","small nucleolar RNA, C/D box 14D///small nucleolar RNA, C/D box 14C///heat shock protein family A (Hsp70) member 8",TRUE
+"221891_x_at",0.957610494018084,0.809772309838339,-0.243612584118298,-5.91081896893088,-0.0488067913555383,"SNORD14D///SNORD14C///HSPA8","small nucleolar RNA, C/D box 14D///small nucleolar RNA, C/D box 14C///heat shock protein family A (Hsp70) member 8",TRUE
+"210338_s_at",0.961981011884773,0.827159663926898,-0.220943667446345,-5.91593488684625,-0.051531478800154,"SNORD14D///SNORD14C///HSPA8","small nucleolar RNA, C/D box 14D///small nucleolar RNA, C/D box 14C///heat shock protein family A (Hsp70) member 8",TRUE
+"208687_x_at",0.970935119871645,0.861064510147898,-0.177066881129132,-5.92442427351749,-0.0406903296114294,"SNORD14D///SNORD14C///HSPA8","small nucleolar RNA, C/D box 14D///small nucleolar RNA, C/D box 14C///heat shock protein family A (Hsp70) member 8",TRUE
+"211710_x_at",0.863835356219448,0.489859734993601,-0.702210544287347,-5.7023250571625,-0.191035672896481,"SNORD18C///SNORD18B///SNORD18A///SNORD16///RPL4","small nucleolar RNA, C/D box 18C///small nucleolar RNA, C/D box 18B///small nucleolar RNA, C/D box 18A///small nucleolar RNA, C/D box 16///ribosomal protein L4",TRUE
+"200089_s_at",0.886943633644753,0.55078915762488,-0.60582215429285,-5.76248517153101,-0.159352473875874,"SNORD18C///SNORD18B///SNORD18A///SNORD16///RPL4","small nucleolar RNA, C/D box 18C///small nucleolar RNA, C/D box 18B///small nucleolar RNA, C/D box 18A///small nucleolar RNA, C/D box 16///ribosomal protein L4",TRUE
+"201154_x_at",0.886966014128658,0.550851723379108,-0.605726237570149,-5.76254078731434,-0.167967981407552,"SNORD18C///SNORD18B///SNORD18A///SNORD16///RPL4","small nucleolar RNA, C/D box 18C///small nucleolar RNA, C/D box 18B///small nucleolar RNA, C/D box 18A///small nucleolar RNA, C/D box 16///ribosomal protein L4",TRUE
+"217850_at",0.910353561703637,0.62734890713982,-0.492301558236938,-5.82232292672101,-0.194299113299321,"SNORD19B///GNL3","small nucleolar RNA, C/D box 19B///G protein nucleolar 3",TRUE
+"217807_s_at",0.931370027472813,0.696629820581691,0.394986306303429,-5.86397909301874,0.14490739743014,"SNORD23///GLTSCR2","small nucleolar RNA, C/D box 23///glioma tumor suppressor candidate region gene 2",TRUE
+"234339_s_at",0.95643295620889,0.802675760853602,0.252901712488183,-5.90857920057938,0.0786322630081262,"SNORD23///GLTSCR2","small nucleolar RNA, C/D box 23///glioma tumor suppressor candidate region gene 2",TRUE
+"234873_x_at",0.993223654424259,0.967723612871678,0.0409232483633223,-5.93886782307403,0.00885735639293195,"SNORD24///SNORD36A///SNORD36B///RPL7A","small nucleolar RNA, C/D box 24///small nucleolar RNA, C/D box 36A///small nucleolar RNA, C/D box 36B///ribosomal protein L7a",TRUE
+"217740_x_at",0.993354935415366,0.968705533297039,0.0396775771984032,-5.93891672141824,0.00911119679564898,"SNORD24///SNORD36A///SNORD36B///RPL7A","small nucleolar RNA, C/D box 24///small nucleolar RNA, C/D box 36A///small nucleolar RNA, C/D box 36B///ribosomal protein L7a",TRUE
+"224930_x_at",0.994050962712312,0.972130676589946,-0.0353329067856821,-5.93907544246438,-0.00797938881389904,"SNORD24///SNORD36A///SNORD36B///RPL7A","small nucleolar RNA, C/D box 24///small nucleolar RNA, C/D box 36A///small nucleolar RNA, C/D box 36B///ribosomal protein L7a",TRUE
+"200715_x_at",0.899808883319249,0.593074563662476,-0.542226682902947,-5.79748788715908,-0.175435616336799,"SNORD32A///SNORD33///SNORD34///SNORD35A///RPL13A","small nucleolar RNA, C/D box 32A///small nucleolar RNA, C/D box 33///small nucleolar RNA, C/D box 34///small nucleolar RNA, C/D box 35A///ribosomal protein L13a",TRUE
+"200031_s_at",0.934200936091995,0.708676665979104,-0.378479430681027,-5.87015312643407,-0.0814754982220975,"SNORD35B///RPS11","small nucleolar RNA, C/D box 35B///ribosomal protein S11",TRUE
+"200858_s_at",0.917601067333473,0.650582872165826,0.459173134681313,-5.83750960065535,0.102739364460438,"SNORD38B///SNORD55///RPS8","small nucleolar RNA, C/D box 38B///small nucleolar RNA, C/D box 55///ribosomal protein S8",TRUE
+"235102_x_at",0.956734254923335,0.80394540070458,0.251238152161247,-5.90898643697445,0.168195568517945,"SNORD3D///SNORD3C///SNORD3B-2///SNORD3A///SNORD3B-1","small nucleolar RNA, C/D box 3D///small nucleolar RNA, C/D box 3C///small nucleolar RNA, C/D box 3B-2///small nucleolar RNA, C/D box 3A///small nucleolar RNA, C/D box 3B-1",TRUE
+"208834_x_at",0.977874971442423,0.89323210389635,0.135766136473744,-5.93070970278853,0.0300221480230718,"SNORD42A///RPL23A","small nucleolar RNA, C/D box 42A///ribosomal protein L23a",TRUE
+"213084_x_at",0.98236740751938,0.914989670378133,0.107972031177629,-5.93400691321854,0.0242842931397291,"SNORD42A///RPL23A","small nucleolar RNA, C/D box 42A///ribosomal protein L23a",TRUE
+"208825_x_at",0.99783553534859,0.989321771483508,0.0135354151407289,-5.9395942475426,0.0030260628124239,"SNORD42A///RPL23A","small nucleolar RNA, C/D box 42A///ribosomal protein L23a",TRUE
+"209181_s_at",0.769258076576208,0.276436601190265,1.11586404534147,-5.35075711461672,0.318741985217633,"SNORD45C///SNORD45A///SNORD45B///RABGGTB","small nucleolar RNA, C/D box 45C///small nucleolar RNA, C/D box 45A///small nucleolar RNA, C/D box 45B///Rab geranylgeranyltransferase beta subunit",TRUE
+"213704_at",0.822010986888098,0.385619767074792,0.885076935565845,-5.5651741032321,0.350776640879827,"SNORD45C///SNORD45A///SNORD45B///RABGGTB","small nucleolar RNA, C/D box 45C///small nucleolar RNA, C/D box 45A///small nucleolar RNA, C/D box 45B///Rab geranylgeranyltransferase beta subunit",TRUE
+"225155_at",0.772598033801268,0.283081351853056,-1.10013845631101,-5.36677883244749,-1.01443972560867,"SNORD50B///SNHG5///SNORD50A","small nucleolar RNA, C/D box 50B///small nucleolar RNA host gene 5///small nucleolar RNA, C/D box 50A",TRUE
+"244669_at",0.730101539866086,0.212936625007908,1.28246040502414,-5.16886528564443,0.698689367412468,"SNORD50B///SNORD50A","small nucleolar RNA, C/D box 50B///small nucleolar RNA, C/D box 50A",TRUE
+"216247_at",0.898336157829132,0.587523467476715,-0.550442022425623,-5.79317775903956,-0.304817015108283,"SNORD54///RPS20","small nucleolar RNA, C/D box 54///ribosomal protein S20",TRUE
+"200949_x_at",0.93803622451021,0.725786946081848,0.355215993913962,-5.87841280429581,0.093979545313152,"SNORD54///RPS20","small nucleolar RNA, C/D box 54///ribosomal protein S20",TRUE
+"214003_x_at",0.985577528508055,0.930464291606731,-0.088258244153318,-5.93589020594607,-0.0205772473163535,"SNORD54///RPS20","small nucleolar RNA, C/D box 54///ribosomal protein S20",TRUE
+"225065_x_at",0.769847953580141,0.278418482913398,1.11114520250257,-5.35558600413786,0.50762105311863,"SNORD65///SNORD49B///LRRC75A-AS1///SNORD49A","small nucleolar RNA, C/D box 65///small nucleolar RNA, C/D box 49B///LRRC75A antisense RNA 1///small nucleolar RNA, C/D box 49A",TRUE
+"244807_at",0.774230543658252,0.286014914822192,1.09328090928315,-5.37370222442353,0.861675397005595,"SNORD65///SNORD49B///LRRC75A-AS1///SNORD49A","small nucleolar RNA, C/D box 65///small nucleolar RNA, C/D box 49B///LRRC75A antisense RNA 1///small nucleolar RNA, C/D box 49A",TRUE
+"239754_at",0.987878312181854,0.942101282533105,0.0734573865840152,-5.93705563583089,0.0297385851352043,"SNORD65///SNORD49B///LRRC75A-AS1///SNORD49A","small nucleolar RNA, C/D box 65///small nucleolar RNA, C/D box 49B///LRRC75A antisense RNA 1///small nucleolar RNA, C/D box 49A",TRUE
+"1565759_at",0.67818193964437,0.145584296764627,1.50838406679582,-4.88838966783972,0.643486753587893,"SNORD68///RPL13","small nucleolar RNA, C/D box 68///ribosomal protein L13",TRUE
+"214976_at",0.936992192746977,0.718543791794872,0.36503879231654,-5.87498829145357,0.137119495714795,"SNORD68///RPL13","small nucleolar RNA, C/D box 68///ribosomal protein L13",TRUE
+"212734_x_at",0.943631120237335,0.747779671134323,0.325603038368254,-5.88817785419153,0.0741277825766389,"SNORD68///RPL13","small nucleolar RNA, C/D box 68///ribosomal protein L13",TRUE
+"212191_x_at",0.958723944343516,0.812737666758252,-0.239737567160366,-5.91172867176806,-0.0665693390309645,"SNORD68///RPL13","small nucleolar RNA, C/D box 68///ribosomal protein L13",TRUE
+"229590_at",0.96351240321323,0.833887388474328,-0.212204668943445,-5.91777439754812,-0.105694397222802,"SNORD68///RPL13","small nucleolar RNA, C/D box 68///ribosomal protein L13",TRUE
+"214351_x_at",0.970573392456845,0.86001205639154,-0.178423089691198,-5.92418980842471,-0.045215436819106,"SNORD68///RPL13","small nucleolar RNA, C/D box 68///ribosomal protein L13",TRUE
+"208929_x_at",0.975196332002567,0.879340013732034,-0.153568571754334,-5.92820344549437,-0.0365948646928604,"SNORD68///RPL13","small nucleolar RNA, C/D box 68///ribosomal protein L13",TRUE
+"212933_x_at",0.988948717228281,0.946583750939926,0.0677608916887819,-5.93744735909012,0.0209446727587821,"SNORD68///RPL13","small nucleolar RNA, C/D box 68///ribosomal protein L13",TRUE
+"212391_x_at",0.833355923558872,0.410794678487759,-0.838336893443968,-5.60304884976696,-0.176824895417637,"SNORD73A///RPS3A","small nucleolar RNA, C/D box 73A///ribosomal protein S3A",TRUE
+"201257_x_at",0.84571977676742,0.443386176052663,-0.78044719639614,-5.64729065299201,-0.166195341824281,"SNORD73A///RPS3A","small nucleolar RNA, C/D box 73A///ribosomal protein S3A",TRUE
+"200099_s_at",0.863569008901048,0.488874036826799,-0.703823546012796,-5.70124616683815,-0.150728221013418,"SNORD73A///RPS3A","small nucleolar RNA, C/D box 73A///ribosomal protein S3A",TRUE
+"216823_at",0.99783553534859,0.989805618540884,0.0129220680108438,-5.93960215135195,0.00491422311419676,"SNORD73A///RPS3A","small nucleolar RNA, C/D box 73A///ribosomal protein S3A",TRUE
+"227517_s_at",0.883410339479976,0.541454415686192,0.620197908376245,-5.75405360263982,0.251969743091131,"SNORD77///SNORD76///SNORD74///GAS5///SNORD44///SNORD47///SNORD80///SNORD79///SNORD81","small nucleolar RNA, C/D box 77///small nucleolar RNA, C/D box 76///small nucleolar RNA, C/D box 74///growth arrest specific 5 (non-protein coding)///small nucleolar RNA, C/D box 44///small nucleolar RNA, C/D box 47///small nucleolar RNA, C/D box 80///small nucleolar RNA, C/D box 79///small nucleolar RNA, C/D box 81",TRUE
+"228238_at",0.914242258486146,0.639451163177936,-0.474978063778209,-5.8303934019777,-0.239496713048778,"SNORD77///SNORD76///SNORD74///GAS5///SNORD44///SNORD47///SNORD80///SNORD79///SNORD81","small nucleolar RNA, C/D box 77///small nucleolar RNA, C/D box 76///small nucleolar RNA, C/D box 74///growth arrest specific 5 (non-protein coding)///small nucleolar RNA, C/D box 44///small nucleolar RNA, C/D box 47///small nucleolar RNA, C/D box 80///small nucleolar RNA, C/D box 79///small nucleolar RNA, C/D box 81",TRUE
+"224741_x_at",0.940604083107865,0.734109875343005,0.343972605174646,-5.88221929239278,0.176733424460958,"SNORD77///SNORD76///SNORD74///GAS5///SNORD44///SNORD47///SNORD80///SNORD79///SNORD81","small nucleolar RNA, C/D box 77///small nucleolar RNA, C/D box 76///small nucleolar RNA, C/D box 74///growth arrest specific 5 (non-protein coding)///small nucleolar RNA, C/D box 44///small nucleolar RNA, C/D box 47///small nucleolar RNA, C/D box 80///small nucleolar RNA, C/D box 79///small nucleolar RNA, C/D box 81",TRUE
+"224841_x_at",0.962555471240652,0.829510910977389,0.217887542694059,-5.91658658585161,0.107960239376563,"SNORD77///SNORD76///SNORD74///GAS5///SNORD44///SNORD47///SNORD80///SNORD79///SNORD81","small nucleolar RNA, C/D box 77///small nucleolar RNA, C/D box 76///small nucleolar RNA, C/D box 74///growth arrest specific 5 (non-protein coding)///small nucleolar RNA, C/D box 44///small nucleolar RNA, C/D box 47///small nucleolar RNA, C/D box 80///small nucleolar RNA, C/D box 79///small nucleolar RNA, C/D box 81",TRUE
+"1566340_at",0.891444650197327,0.561095233083524,0.590098501786306,-5.77148867274856,0.358721352529476,"SNORD8","small nucleolar RNA, C/D box 8",TRUE
+"1566339_at",0.892746695408886,0.565803074024148,0.582965776477009,-5.77549746107004,0.400931646151578,"SNORD8","small nucleolar RNA, C/D box 8",TRUE
+"201217_x_at",0.920394557577588,0.661253198284504,0.444133997122757,-5.84406185552072,0.10287628609353,"SNORD83B///SNORD139///RPL3","small nucleolar RNA, C/D box 83B///small nucleolar RNA, C/D box 139///ribosomal protein L3",TRUE
+"212039_x_at",0.930899509890345,0.694298285778756,0.398193828312188,-5.86274926252084,0.0933035134697029,"SNORD83B///SNORD139///RPL3","small nucleolar RNA, C/D box 83B///small nucleolar RNA, C/D box 139///ribosomal protein L3",TRUE
+"211073_x_at",0.932830928398943,0.703596319845597,0.385427323009544,-5.86758607821198,0.0926788258724507,"SNORD83B///SNORD139///RPL3","small nucleolar RNA, C/D box 83B///small nucleolar RNA, C/D box 139///ribosomal protein L3",TRUE
+"211666_x_at",0.99388023907845,0.971043890986594,-0.0367113754579938,-5.93902707486817,-0.00902600890931993,"SNORD83B///SNORD139///RPL3","small nucleolar RNA, C/D box 83B///small nucleolar RNA, C/D box 139///ribosomal protein L3",TRUE
+"225547_at",0.877223961993707,0.526513758247986,0.643485803410282,-5.73999104437655,0.938088075319371,"SNORD87///SNHG6","small nucleolar RNA, C/D box 87///small nucleolar RNA host gene 6",TRUE
+"224468_s_at",0.979454258428964,0.901115831870028,-0.125683622371789,-5.93199257743086,-0.0562124634988219,"SNORD88C///C19orf48","small nucleolar RNA, C/D box 88C///chromosome 19 open reading frame 48",TRUE
+"235536_at",0.729273475042162,0.211497904914556,1.28664957760095,-5.16401118426893,0.443668577062132,"SNORD89","small nucleolar RNA, C/D box 89",TRUE
+"200651_at",0.955892698633978,0.799701313530032,-0.256801883250773,-5.90761397503779,-0.0586677904478083,"SNORD96A///SNORD95///RACK1","small nucleolar RNA, C/D box 96A///small nucleolar RNA, C/D box 95///receptor for activated C kinase 1",TRUE
+"222034_at",0.960699983781935,0.821607522658304,0.228168884539475,-5.91435823186257,0.129103562076072,"SNORD96A///SNORD95///RACK1","small nucleolar RNA, C/D box 96A///small nucleolar RNA, C/D box 95///receptor for activated C kinase 1",TRUE
+"205104_at",0.954672574687803,0.793597042397996,0.264818797539018,-5.90558383901877,0.298486519309422,"SNPH","syntaphilin",TRUE
+"207474_at",0.811263413918865,0.355363328945391,0.943974361752699,-5.51474434437486,0.749806462828904,"SNRK","SNF related kinase",TRUE
+"1564514_at",0.932249295738588,0.7010502135119,-0.388916641570305,-5.86627951078252,-0.291888554503548,"SNRK","SNF related kinase",TRUE
+"209481_at",0.996625121774816,0.983219054869613,-0.0212720408263381,-5.93946308722184,-0.00893091576774907,"SNRK","SNF related kinase",TRUE
+"237942_at",0.934048461921637,0.708014713413449,-0.379383636866001,-5.86982165439859,-0.15452009754391,"SNRK-AS1","SNRK antisense RNA 1",TRUE
+"232931_at",0.875187315707138,0.522224305055824,0.650237876515855,-5.73582060617907,0.279585961327568,"SNRNP200","small nuclear ribonucleoprotein U5 subunit 200",TRUE
+"218493_at",0.605318445040235,0.079048444400316,-1.84102457537889,-4.41129181798509,-0.875012633934007,"SNRNP25","small nuclear ribonucleoprotein U11/U12 subunit 25",TRUE
+"212440_at",0.660629689911776,0.128646077887347,-1.57839656958688,-4.7940403960232,-0.406162242950563,"SNRNP27","small nuclear ribonucleoprotein U4/U6.U5 subunit 27",TRUE
+"212438_at",0.919354071504066,0.656547240090185,-0.450753714604557,-5.84120413403499,-0.144161379867141,"SNRNP27","small nuclear ribonucleoprotein U4/U6.U5 subunit 27",TRUE
+"205300_s_at",0.808930448510815,0.352112222114474,-0.950499735081295,-5.50897341791903,-0.350496624404139,"SNRNP35","small nuclear ribonucleoprotein U11/U12 subunit 35",TRUE
+"215905_s_at",0.997171203405,0.985660147751391,-0.018177250064746,-5.93952255032293,-0.00715904803260692,"SNRNP40","small nuclear ribonucleoprotein U5 subunit 40",TRUE
+"1553274_a_at",0.497725944448536,0.0306000904124668,2.3096983028566,-3.62971149273385,0.994735106132181,"SNRNP48","small nuclear ribonucleoprotein U11/U12 subunit 48",TRUE
+"226263_at",0.791646964605038,0.322168175574664,1.01262986011563,-5.45221227242484,0.544778285887993,"SNRNP48","small nuclear ribonucleoprotein U11/U12 subunit 48",TRUE
+"213121_at",0.932918358096654,0.703895398786939,0.385017769838616,-5.86773867333658,0.264524150433544,"SNRNP70","small nuclear ribonucleoprotein U1 subunit 70",TRUE
+"201221_s_at",0.943988850936011,0.749132933211865,-0.323790820549664,-5.88874815219358,-0.0772889030884585,"SNRNP70","small nuclear ribonucleoprotein U1 subunit 70",TRUE
+"201770_at",0.95545456494849,0.795853896605105,-0.261852768173551,-5.90634215650985,-0.0681774867221954,"SNRPA","small nuclear ribonucleoprotein polypeptide A",TRUE
+"242146_at",0.908709061737317,0.620483901176831,0.502196295247315,-5.81758657327783,0.265019388130035,"SNRPA1","small nuclear ribonucleoprotein polypeptide A'",TRUE
+"206055_s_at",0.934529238427318,0.7095414311037,-0.377298672743941,-5.87058480478588,-0.102136311461086,"SNRPA1","small nuclear ribonucleoprotein polypeptide A'",TRUE
+"215722_s_at",0.956960361976289,0.804809584753341,-0.250106259596116,-5.9092619949926,-0.0842551102623776,"SNRPA1","small nuclear ribonucleoprotein polypeptide A'",TRUE
+"216977_x_at",0.990918916504081,0.957300375048916,0.0541507334371191,-5.93825536550946,0.0190963679824154,"SNRPA1","small nuclear ribonucleoprotein polypeptide A'",TRUE
+"208821_at",0.897375964261386,0.583922170654364,-0.555792281986041,-5.79033693585667,-0.221104229735822,"SNRPB","small nuclear ribonucleoprotein polypeptides B and B1",TRUE
+"213175_s_at",0.936318756756998,0.715555334278629,-0.369102218373329,-5.87354469909152,-0.130198491530804,"SNRPB","small nuclear ribonucleoprotein polypeptides B and B1",TRUE
+"202505_at",0.853768202875953,0.462481141611494,-0.747738041624632,-5.67096908418967,-0.263831244604692,"SNRPB2","small nuclear ribonucleoprotein polypeptide B2",TRUE
+"1561965_at",0.885029460971826,0.545843780620822,0.613421945116746,-5.75805155030951,0.491495681252411,"SNRPB2","small nuclear ribonucleoprotein polypeptide B2",TRUE
+"201342_at",0.725934062811456,0.204997315113605,1.3058571647492,-5.14158276668716,0.38668145860027,"SNRPC","small nuclear ribonucleoprotein polypeptide C",TRUE
+"202690_s_at",0.839519981963042,0.42652389515504,0.810054348414984,-5.62503461628659,0.213903994468344,"SNRPD1","small nuclear ribonucleoprotein D1 polypeptide",TRUE
+"202691_at",0.968980656821882,0.853409859003912,0.186938712253073,-5.92267685225497,0.0587720469258546,"SNRPD1","small nuclear ribonucleoprotein D1 polypeptide",TRUE
+"200826_at",0.760463372361683,0.259530898555579,-1.15715857843087,-5.30772924609398,-0.288863235419518,"SNRPD2","small nuclear ribonucleoprotein D2 polypeptide",TRUE
+"202567_at",0.800179799309599,0.335747470640845,-0.983983135827945,-5.47878995244969,-0.286360468989153,"SNRPD3","small nuclear ribonucleoprotein D3 polypeptide",TRUE
+"203316_s_at",0.635626505801859,0.106651373866436,-1.68179450582598,-4.64863417792683,-0.363954563554307,"SNRPE","small nuclear ribonucleoprotein polypeptide E",TRUE
+"231112_at",0.800342373547779,0.335961870349644,-0.983537317799201,-5.47919809172662,-0.617625715378927,"SNRPE","small nuclear ribonucleoprotein polypeptide E",TRUE
+"215450_at",0.933599541599416,0.706020841026366,-0.382109154129776,-5.86881779082997,-0.107351785895904,"SNRPE","small nuclear ribonucleoprotein polypeptide E",TRUE
+"203832_at",0.906507435035949,0.614487818197632,-0.510880360032141,-5.81335396232166,-0.186653987927134,"SNRPF","small nuclear ribonucleoprotein polypeptide F",TRUE
+"205644_s_at",0.884122836669679,0.542876095043504,0.618000039699598,-5.75535502559675,0.161959118914348,"SNRPG","small nuclear ribonucleoprotein polypeptide G",TRUE
+"240204_at",0.913160385122315,0.6356175909422,0.480449350780706,-5.82787503948267,0.297952588381122,"SNRPN","small nuclear ribonucleoprotein polypeptide N",TRUE
+"203516_at",0.702630084418366,0.174226771164044,1.40384443223207,-5.02283377815694,0.602939733242481,"SNTA1","syntrophin alpha 1",TRUE
+"214708_at",0.542397752248982,0.045536285704291,-2.11895406593406,-3.96151919746689,-2.07145611034793,"SNTB1","syntrophin beta 1",TRUE
+"215431_at",0.800342373547779,0.336046865297616,0.983360635352961,-5.47935979508988,0.604767399134014,"SNTB1","syntrophin beta 1",TRUE
+"208608_s_at",0.948015976270656,0.763880718795871,-0.304111442519737,-5.89473816485886,-0.178267195352231,"SNTB1","syntrophin beta 1",TRUE
+"226438_at",0.968451827985008,0.852086901473983,0.188646766527682,-5.92236492161223,0.0861003370360462,"SNTB1","syntrophin beta 1",TRUE
+"205315_s_at",0.604561007744788,0.0786952115614021,1.84335603073232,-4.40770103480014,0.482127426121023,"SNTB2","syntrophin beta 2",TRUE
+"213814_s_at",0.643082025527735,0.113537854892659,-1.64763412987238,-4.69745627823874,-0.742667534107063,"SNTB2","syntrophin beta 2",TRUE
+"205314_x_at",0.674414116535964,0.140803605674587,1.52743431246985,-4.86305365882939,0.610980706983552,"SNTB2","syntrophin beta 2",TRUE
+"227312_at",0.852762919754104,0.458830902118449,0.75392705238799,-5.66656234323449,0.326181377648282,"SNTB2","syntrophin beta 2",TRUE
+"238925_at",0.912244494826693,0.632239243575087,0.485283296367796,-5.82562656920882,0.147087749754144,"SNTB2","syntrophin beta 2",TRUE
+"214350_at",0.912722788750542,0.6340574643187,0.482680225252733,-5.82684010121491,0.301026207351361,"SNTB2","syntrophin beta 2",TRUE
+"226685_at",0.914910510855952,0.641534967973407,0.472010220969324,-5.83174765519182,0.165585346241766,"SNTB2","syntrophin beta 2",TRUE
+"234919_s_at",0.743553048228796,0.23415860448501,1.22305489270634,-5.23623848873514,0.650826799966494,"SNTG1","syntrophin gamma 1",TRUE
+"220405_at",0.820536502908875,0.380541233167185,0.894743869138877,-5.55710278108016,0.473895338454681,"SNTG1","syntrophin gamma 1",TRUE
+"1562287_at",0.909441642299191,0.623907201680348,-0.497255900650715,-5.81996291492754,-0.455523276590567,"SNTG1","syntrophin gamma 1",TRUE
+"1570422_at",0.71242055183987,0.186586586074052,1.36296245734792,-5.07324969590033,0.806413491568358,"SNTG2","syntrophin gamma 2",TRUE
+"220487_at",0.73957587762701,0.228125037486618,1.23951130926021,-5.217849858971,0.396745994647451,"SNTG2","syntrophin gamma 2",TRUE
+"239150_at",0.818999571709518,0.373002438685665,0.909251487835823,-5.54483765032353,0.725075481883885,"SNTN","sentan, cilia apical structure protein",TRUE
+"230443_at",0.875938621758472,0.524379270362603,0.646841941950753,-5.73792334099444,0.616030936286411,"SNU13","SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)",TRUE
+"201076_at",0.966561892743893,0.843888606143673,-0.199244511866419,-5.92036634217894,-0.0642900036255849,"SNU13","SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)",TRUE
+"201077_s_at",0.93789466363241,0.725406459407265,0.355731096749413,-5.8782355166516,0.106387537461394,"SNU13///ANXA2","SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)///annexin A2",TRUE
+"207438_s_at",0.930409774479405,0.692271035033814,0.400986201034195,-5.86167063339308,0.19240884969553,"SNUPN","snurportin 1",TRUE
+"206042_x_at",0.724275694298914,0.201534544087711,1.31628249875253,-5.12929144924893,3.05722835707027,"SNURF///SNRPN","SNRPN upstream reading frame///small nuclear ribonucleoprotein polypeptide N",TRUE
+"1560741_at",0.737651450894455,0.224472699405248,1.24963451812522,-5.20643294716328,0.953259527936553,"SNURF///SNRPN","SNRPN upstream reading frame///small nuclear ribonucleoprotein polypeptide N",TRUE
+"201522_x_at",0.789378278298554,0.315855002908482,1.02623475702673,-5.43934817097862,1.37166856492221,"SNURF///SNRPN","SNRPN upstream reading frame///small nuclear ribonucleoprotein polypeptide N",TRUE
+"201575_at",0.768691960323651,0.271850530312174,-1.12687880657605,-5.33941499303024,-0.315284348326758,"SNW1","SNW domain containing 1",TRUE
+"215424_s_at",0.79943091106207,0.334122725597611,-0.98736798113464,-5.47568569009951,-0.30554196648278,"SNW1","SNW domain containing 1",TRUE
+"201716_at",0.538516443343925,0.0440367081516358,-2.13529664799445,-3.933783340264,-0.648148897906767,"SNX1","sorting nexin 1",TRUE
+"214531_s_at",0.55074985379986,0.0489791647997692,-2.08319218917178,-4.0217373210294,-0.771962747554985,"SNX1","sorting nexin 1",TRUE
+"216357_at",0.934193918007432,0.708603386696008,-0.378579512025554,-5.8701164761079,-0.23317455233245,"SNX1","sorting nexin 1",TRUE
+"213364_s_at",0.956398858120188,0.80200590795663,-0.253779688711188,-5.9083631968202,-0.227063351097846,"SNX1","sorting nexin 1",TRUE
+"218404_at",0.700890836612645,0.172596147138887,1.40940884903384,-5.01587650094146,1.54062303300376,"SNX10","sorting nexin 10",TRUE
+"53912_at",0.931370027472813,0.696296101471874,-0.395445148585607,-5.86380376387529,-0.166259042049903,"SNX11","sorting nexin 11",TRUE
+"220140_s_at",0.994050962712312,0.972205384434553,0.0352381506644363,-5.93907869927941,0.0125319250803955,"SNX11","sorting nexin 11",TRUE
+"231723_at",0.857287594027564,0.472265296492862,0.731290902157789,-5.68251249264027,0.306661804147858,"SNX12","sorting nexin 12",TRUE
+"224684_at",0.942303845415102,0.740324798880096,0.335606369594495,-5.88497316600977,0.109245659428549,"SNX12","sorting nexin 12",TRUE
+"213292_s_at",0.850727497058135,0.453814690063056,-0.76248042083715,-5.66041554767978,-0.227647103528687,"SNX13","sorting nexin 13",TRUE
+"215366_at",0.873301865850313,0.518306229640098,0.656432033797359,-5.73195802065433,0.202534955520925,"SNX13","sorting nexin 13",TRUE
+"1553148_a_at",0.893471022209827,0.568406082588466,0.579035117307816,-5.77768643762047,0.216989929975023,"SNX13","sorting nexin 13",TRUE
+"227031_at",0.949038895598021,0.770174909957494,-0.295750135721747,-5.8971705403472,-0.11107150434627,"SNX13","sorting nexin 13",TRUE
+"215820_x_at",0.982476966653206,0.915371834748268,0.107484680203433,-5.934058027734,0.0367268049672038,"SNX13","sorting nexin 13",TRUE
+"230759_at",0.885312914741353,0.546805198318587,0.61194164953942,-5.75891931687875,0.214070174461186,"SNX14","sorting nexin 14",TRUE
+"225101_s_at",0.923004698880603,0.670053696202515,0.43180824457296,-5.84927229529757,0.155383407057208,"SNX14","sorting nexin 14",TRUE
+"205482_x_at",0.872668627020452,0.516446423951376,-0.659381281780215,-5.73010656859953,-0.198221809191782,"SNX15","sorting nexin 15",TRUE
+"219793_at",0.623503825356688,0.0945723973730127,-1.74651467117508,-4.55407346672985,-0.793082327452831,"SNX16","sorting nexin 16",TRUE
+"229618_at",0.7768734672127,0.29497284998783,-1.07264961499383,-5.39429878822311,-0.517059586333179,"SNX16","sorting nexin 16",TRUE
+"200991_s_at",0.992342196993659,0.963951796095911,-0.0457088366176415,-5.93866591208383,-0.0195643979782005,"SNX17","sorting nexin 17",TRUE
+"1552828_at",0.955730092376044,0.797743110160091,0.259371749127485,-5.90696995531733,0.116076801791498,"SNX18","sorting nexin 18",TRUE
+"226683_at",0.968271298107834,0.85104451042603,-0.189992989221975,-5.92211707746463,-0.0992154043305771,"SNX18","sorting nexin 18",TRUE
+"1561710_at",0.91539387234353,0.643192777241695,-0.469652169054869,-5.83281773242292,-0.426424971227597,"SNX19","sorting nexin 19",TRUE
+"1554986_a_at",0.953983577550391,0.788458241804035,-0.271581484325775,-5.90382312074018,-0.106401756287958,"SNX19","sorting nexin 19",TRUE
+"202359_s_at",0.959969342594555,0.818848792404077,0.231763526856516,-5.91355502184314,0.277326450693812,"SNX19","sorting nexin 19",TRUE
+"202358_s_at",0.98428730171779,0.923646263282617,-0.09693913535003,-5.93510748932248,-0.0938314801243187,"SNX19","sorting nexin 19",TRUE
+"202113_s_at",0.530336492085393,0.0415054384935235,-2.16405770965893,-3.88464614439349,-0.72309684134934,"SNX2","sorting nexin 2",TRUE
+"202114_at",0.567651250567208,0.0577289427708153,-2.00153475620961,-4.15672356508045,-0.71039436821553,"SNX2","sorting nexin 2",TRUE
+"232049_at",0.704989495199878,0.176782718916811,-1.39520543490022,-5.03359024715383,-0.759239934016162,"SNX2","sorting nexin 2",TRUE
+"1563641_a_at",0.597654932724127,0.0750139671067345,1.8682113892392,-4.36921945927433,0.903502566801121,"SNX20","sorting nexin 20",TRUE
+"228869_at",0.835952408568777,0.417043545143269,0.827020617412838,-5.61193044995615,0.540826669662716,"SNX20","sorting nexin 20",TRUE
+"229045_at",0.842167419664876,0.435483169618342,-0.794235350956241,-5.63702291274015,-0.653500017055615,"SNX20","sorting nexin 20",TRUE
+"1553960_at",0.890943934856426,0.560057426304554,-0.59167500678686,-5.77059627206948,-0.297815778920013,"SNX21","sorting nexin family member 21",TRUE
+"1553961_s_at",0.943177611554239,0.744709236228559,-0.329718943351011,-5.88687089210883,-0.195264603989426,"SNX21","sorting nexin family member 21",TRUE
+"226595_at",0.995111934465262,0.977095846722416,0.0290359825281179,-5.93927285187455,0.0203237674041112,"SNX21","sorting nexin family member 21",TRUE
+"235460_at",0.675118548055585,0.141270160252601,1.52555200697746,-4.86556832310501,0.721497516108808,"SNX22","sorting nexin 22",TRUE
+"230509_at",0.8920930097751,0.562903571783582,-0.587355100235786,-5.77303612053777,-0.143010873481939,"SNX22","sorting nexin 22",TRUE
+"1569481_s_at",0.932633693661011,0.702499840244339,0.386929396782887,-5.8670250528213,0.144463100357322,"SNX22","sorting nexin 22",TRUE
+"233883_at",0.895594830714116,0.574826301501589,0.569379368068774,-5.78300281111197,0.364211224296365,"SNX24","sorting nexin 24",TRUE
+"218705_s_at",0.898609426925686,0.58819474775376,-0.549446534605115,-5.79370338805741,-0.300015325944585,"SNX24","sorting nexin 24",TRUE
+"239693_at",0.912141993216912,0.631701080441854,-0.486054414024379,-5.82526585501277,-0.415140382630756,"SNX24","sorting nexin 24",TRUE
+"222716_s_at",0.966051687342135,0.841549734282257,-0.202272147964804,-5.91977539385218,-0.121628739325324,"SNX24","sorting nexin 24",TRUE
+"239739_at",0.996771621728225,0.983642980776038,0.0207345778065874,-5.93947408341429,0.018356175911193,"SNX24","sorting nexin 24",TRUE
+"227311_at",0.623667408398064,0.0953332776361062,1.74223549060475,-4.56040771428834,1.22816596252112,"SNX25","sorting nexin 25",TRUE
+"232425_at",0.73957587762701,0.228141391268845,1.23946626007092,-5.21790048668477,1.01522956847379,"SNX25","sorting nexin 25",TRUE
+"230066_at",0.853460708803218,0.461879622903477,-0.748755908233782,-5.67024669961793,-0.323203106149756,"SNX25","sorting nexin 25",TRUE
+"227408_s_at",0.93099243231938,0.694698294536188,0.397643229929845,-5.86296106984757,0.192599345317761,"SNX25","sorting nexin 25",TRUE
+"1555388_s_at",0.94895689004559,0.768313578612939,0.298220491018071,-5.89645888978359,0.15513905533519,"SNX25","sorting nexin 25",TRUE
+"221498_at",0.687949239097856,0.157233407047821,-1.46401829000187,-4.94640345906151,-0.507161489877554,"SNX27","sorting nexin family member 27",TRUE
+"221006_s_at",0.992451894371035,0.964805571902381,-0.0446254952048576,-5.93871357281814,-0.0240079398843083,"SNX27","sorting nexin family member 27",TRUE
+"225608_at",0.774230543658252,0.28889526735842,1.08659699247642,-5.38041321536257,0.5645169370678,"SNX29","sorting nexin 29",TRUE
+"232485_at",0.780756955782067,0.302506727961359,1.05564286692906,-5.41101290590788,0.347549243396271,"SNX29","sorting nexin 29",TRUE
+"1558745_at",0.790492926385938,0.320230961619061,1.0167845781539,-5.44830024713341,0.652515101993854,"SNX29","sorting nexin 29",TRUE
+"225624_at",0.9114480626414,0.629720809924957,-0.488894463332739,-5.82393250672296,-0.178164841185113,"SNX29","sorting nexin 29",TRUE
+"215500_at",0.941161916043887,0.736320442338927,0.340994007040539,-5.88320742977803,0.234323091980841,"SNX29","sorting nexin 29",TRUE
+"1554413_s_at",0.813418501361393,0.363393878632892,-0.928026521166501,-5.52869470222559,-0.794990541409055,"SNX29P1///SNX29P2","sorting nexin 29 pseudogene 1///sorting nexin 29 pseudogene 2",TRUE
+"1559297_at",0.877271158601418,0.526671629107373,0.643237872444291,-5.74014338376471,0.499970734075232,"SNX29P2","sorting nexin 29 pseudogene 2",TRUE
+"214712_at",0.988438753637362,0.944842091727599,-0.0699739763031551,-5.93729892697412,-0.0743139400694721,"SNX29P2","sorting nexin 29 pseudogene 2",TRUE
+"200067_x_at",0.62282585384278,0.0933672161496886,1.75335331893968,-4.543926737418,0.506132818772452,"SNX3","sorting nexin 3",TRUE
+"210648_x_at",0.681732274610686,0.149376941477043,1.49363190140118,-4.9078345597655,0.396420579715601,"SNX3","sorting nexin 3",TRUE
+"213545_x_at",0.7508466884305,0.243923893551029,1.19708737758654,-5.26482198694607,0.390447895445078,"SNX3","sorting nexin 3",TRUE
+"208781_x_at",0.756313947022433,0.251283008809542,1.17802967200464,-5.28545992142544,0.32466111973385,"SNX3","sorting nexin 3",TRUE
+"226249_at",0.997654912087849,0.988494982452048,-0.0145835039837924,-5.93957989338094,-0.00703973548374037,"SNX30","sorting nexin family member 30",TRUE
+"241987_x_at",0.909069952277897,0.622897397057617,-0.498711908005525,-5.81926495545742,-0.360765545302618,"SNX31","sorting nexin 31",TRUE
+"231194_at",0.937462538530338,0.72264898650383,0.359467106317101,-5.87694206555258,0.249990968172187,"SNX32","sorting nexin 32",TRUE
+"1554181_at",0.939976205834042,0.730177064183851,0.349279690760714,-5.8804376363601,0.139801492640528,"SNX32","sorting nexin 32",TRUE
+"229898_at",0.776063130338123,0.293431451747882,1.07616728352959,-5.39081181749338,0.460828576284784,"SNX33","sorting nexin 33",TRUE
+"227151_at",0.998038817582822,0.991050937948933,-0.0113434657455437,-5.93962080847741,-0.00348531423779974,"SNX33","sorting nexin 33",TRUE
+"212652_s_at",0.268560525805689,0.00415550443221971,-3.19501648821549,-1.9091334960958,-1.11872862797853,"SNX4","sorting nexin 4",TRUE
+"205329_s_at",0.552420073963858,0.0500676363527484,-2.07235505469406,-4.03985508804728,-0.663427952072304,"SNX4","sorting nexin 4",TRUE
+"229981_at",0.740668810029442,0.230814864016024,1.23213453910465,-5.22611898055078,0.577471681534608,"SNX5","sorting nexin 5",TRUE
+"223666_at",0.931370027472813,0.69645250123885,0.395230098227256,-5.86388596216396,0.293930884794549,"SNX5","sorting nexin 5",TRUE
+"217792_at",0.951810226174863,0.778949915199591,-0.284128950015196,-5.90043954753263,-0.116131989007942,"SNX5","sorting nexin 5",TRUE
+"229980_s_at",0.953983577550391,0.787950154329674,0.272250828087488,-5.90364645424979,0.0855119345910538,"SNX5","sorting nexin 5",TRUE
+"238433_at",0.993892931327222,0.97126434318736,-0.0364317501474675,-5.93903703596711,-0.025551453711695,"SNX5","sorting nexin 5",TRUE
+"222417_s_at",0.998870448604467,0.995253976382072,-0.00601576888795013,-5.93966585420534,-0.00211323955063136,"SNX5","sorting nexin 5",TRUE
+"222410_s_at",0.940756067985891,0.734861363797462,-0.342959667767109,-5.88255628357997,-0.102344701617085,"SNX6","sorting nexin 6",TRUE
+"217789_at",0.995375928428862,0.978473207595608,0.0272894112764583,-5.93932076551638,0.00838593302050228,"SNX6","sorting nexin 6",TRUE
+"205573_s_at",0.820288124919738,0.378367898655294,0.898906646847683,-5.55360211311418,1.10178057210408,"SNX7","sorting nexin 7",TRUE
+"243135_x_at",0.843991178026838,0.440295571483484,0.785821193746265,-5.64330889444599,0.633030411132819,"SNX8","sorting nexin 8",TRUE
+"223028_s_at",0.677013732819214,0.143890796396104,1.51507292254016,-4.87952267948056,0.500339529390843,"SNX9","sorting nexin 9",TRUE
+"223027_at",0.867717011547419,0.500646257664522,0.684679544246402,-5.7138986438744,0.297507357727184,"SNX9","sorting nexin 9",TRUE
+"228479_at",0.585036027492332,0.0656766229221208,1.9363988994235,-4.26179837500193,1.43138389075163,"SOAT1","sterol O-acyltransferase 1",TRUE
+"244661_at",0.681732274610686,0.149419739965722,1.49346718231991,-4.90805081085797,1.32197089291262,"SOAT1","sterol O-acyltransferase 1",TRUE
+"221561_at",0.697172073261335,0.167156890810916,1.42827946401357,-4.99211391133908,1.84394831310418,"SOAT1","sterol O-acyltransferase 1",TRUE
+"210677_at",0.933314818367461,0.704947524794897,-0.383577540039689,-5.86827401739845,-0.286568722398994,"SOAT2","sterol O-acyltransferase 2",TRUE
+"229646_at",0.556381379241158,0.0518233728919808,2.05531111185463,-4.06822513641672,1.58312740831061,"SOBP","sine oculis binding protein homolog",TRUE
+"1569351_at",0.622434989367596,0.0929497884525564,1.75573960504525,-4.54037923975879,0.530383629952637,"SOBP","sine oculis binding protein homolog",TRUE
+"229034_at",0.841420204214686,0.432313788738034,0.799808135041319,-5.63282497350272,0.562916146367995,"SOBP","sine oculis binding protein homolog",TRUE
+"234098_at",0.8920930097751,0.563294376782217,-0.586762814305317,-5.77336929096505,-0.493616878323485,"SOBP","sine oculis binding protein homolog",TRUE
+"244279_at",0.901788521024914,0.59924865218998,-0.533133443995124,-5.80218512521612,-0.411199883631314,"SOBP","sine oculis binding protein homolog",TRUE
+"1563906_at",0.9116561917482,0.630520954655159,0.487746428207402,-5.824472401208,0.385172116102872,"SOBP","sine oculis binding protein homolog",TRUE
+"218974_at",0.932091525948902,0.69974168629289,-0.39071182765958,-5.86560278644054,-0.356107322048708,"SOBP","sine oculis binding protein homolog",TRUE
+"233766_at",0.978630150400733,0.896616737522157,-0.131435819059731,-5.93127278399464,-0.12210493199528,"SOBP","sine oculis binding protein homolog",TRUE
+"209999_x_at",0.673366993714442,0.139388693355102,1.53317426391386,-4.85537016124635,1.21082446172823,"SOCS1","suppressor of cytokine signaling 1",TRUE
+"210001_s_at",0.897024165042344,0.583058751682831,0.557077453760899,-5.78965057609602,0.261090288162212,"SOCS1","suppressor of cytokine signaling 1",TRUE
+"210000_s_at",0.901788521024914,0.599701000416119,0.532469016718331,-5.80252531489855,0.451857129797196,"SOCS1","suppressor of cytokine signaling 1",TRUE
+"213337_s_at",0.928596293858875,0.686132190118882,0.409461892762172,-5.85835123106309,0.120409993352832,"SOCS1","suppressor of cytokine signaling 1",TRUE
+"232539_at",0.661121988136487,0.128825136478154,1.57761760640788,-4.79510866929494,0.835100436478931,"SOCS2","suppressor of cytokine signaling 2",TRUE
+"203373_at",0.908667507590078,0.61993612710503,0.502987998463606,-5.81720363044915,0.517890013388634,"SOCS2","suppressor of cytokine signaling 2",TRUE
+"203372_s_at",0.943988850936011,0.749238567073579,0.323649407814955,-5.88879252170989,0.35435480508556,"SOCS2","suppressor of cytokine signaling 2",TRUE
+"1559315_s_at",0.963934535918029,0.83496917459676,-0.210801073743981,-5.91806295871312,-0.133449318790607,"SOCS2-AS1","SOCS2 antisense RNA 1",TRUE
+"206360_s_at",0.756313947022433,0.251456984039676,-1.17758420889036,-5.28593886456425,-0.373641699250404,"SOCS3","suppressor of cytokine signaling 3",TRUE
+"214105_at",0.904432955312383,0.608276929204681,0.51991769436513,-5.8088740508968,0.228586087235711,"SOCS3","suppressor of cytokine signaling 3",TRUE
+"206359_at",0.957571530817866,0.80897688181597,0.244652665943089,-5.91057232947691,0.242606374805036,"SOCS3","suppressor of cytokine signaling 3",TRUE
+"227697_at",0.974982245454858,0.878028666898781,0.155251572153802,-5.92795058775652,0.172427183131573,"SOCS3","suppressor of cytokine signaling 3",TRUE
+"226178_at",0.304824368772306,0.00601428475461637,-3.03741060313127,-2.23211323540539,-0.894129912819889,"SOCS4","suppressor of cytokine signaling 4",TRUE
+"1552792_at",0.919176489727468,0.655822128290234,-0.45177551951528,-5.84075932856747,-0.189135045279922,"SOCS4","suppressor of cytokine signaling 4",TRUE
+"209648_x_at",0.73957587762701,0.228043690367645,1.23973542984979,-5.21759796156928,0.60570281486166,"SOCS5","suppressor of cytokine signaling 5",TRUE
+"208127_s_at",0.789224993491684,0.315502344448976,1.02700033294708,-5.43861967200132,0.493100424798094,"SOCS5","suppressor of cytokine signaling 5",TRUE
+"209647_s_at",0.857964270126169,0.473649630168967,0.728980156508891,-5.68411476382066,0.290656684315916,"SOCS5","suppressor of cytokine signaling 5",TRUE
+"214462_at",0.905166341446495,0.610849146857898,0.516169636479321,-5.81074129852133,0.270297346522156,"SOCS6","suppressor of cytokine signaling 6",TRUE
+"206020_at",0.947559391160104,0.760985013014004,0.307965553510369,-5.89359434192223,0.252774212459475,"SOCS6","suppressor of cytokine signaling 6",TRUE
+"227542_at",0.986145735582101,0.932194365092712,0.0860566014229113,-5.93607706212534,0.0873098691887275,"SOCS6","suppressor of cytokine signaling 6",TRUE
+"214015_at",0.789661545166663,0.317132567423732,-1.02346634067867,-5.44197841808773,-0.392226545193766,"SOCS7","suppressor of cytokine signaling 7",TRUE
+"228662_at",0.900717283106192,0.596129046300515,-0.537722287432506,-5.79982435052953,-0.284351605400447,"SOCS7","suppressor of cytokine signaling 7",TRUE
+"226572_at",0.931782618873831,0.698798619191634,-0.392006444642263,-5.86511285386681,-0.213516209951349,"SOCS7","suppressor of cytokine signaling 7",TRUE
+"200642_at",0.919843115477007,0.658955924042129,-0.447362960715878,-5.84267309769938,-0.10318482378338,"SOD1","superoxide dismutase 1, soluble",TRUE
+"1566342_at",0.642592458809121,0.112679283012691,1.65179609565003,-4.69154884575516,0.874463576612041,"SOD2","superoxide dismutase 2, mitochondrial",TRUE
+"205236_x_at",0.901430889731657,0.598191614857628,0.534687010982346,-5.80138808137152,0.386862574765794,"SOD3","superoxide dismutase 3, extracellular",TRUE
+"225473_at",0.530436287357652,0.0415431793143746,-2.16361737995632,-3.88540152864653,-0.922147616662249,"SOGA1","suppressor of glucose, autophagy associated 1",TRUE
+"207711_at",0.636860247875294,0.107970820795778,-1.67510788996869,-4.65825060348788,-0.713994840986245,"SOGA1","suppressor of glucose, autophagy associated 1",TRUE
+"241362_at",0.773657212801073,0.285125019816368,-1.09535574816297,-5.37161152754345,-0.514087367028061,"SOGA1","suppressor of glucose, autophagy associated 1",TRUE
+"215852_x_at",0.97928472590149,0.899791078506301,0.127376890344216,-5.93178403218057,0.0372159861799473,"SOGA1","suppressor of glucose, autophagy associated 1",TRUE
+"233050_at",0.695739345331756,0.165164722647134,1.43531430407845,-4.98318911823019,1.20815646404323,"SOGA3///KIAA0408","SOGA family member 3///KIAA0408",TRUE
+"1569146_s_at",0.985032035638346,0.926209363551301,0.0936748708195887,-5.93541041441697,0.0519628208859646,"SOGA3///KIAA0408","SOGA family member 3///KIAA0408",TRUE
+"1561403_at",0.951934441578502,0.779825648647614,0.282971388182388,-5.90075804737556,0.149334937494021,"SOHLH1","spermatogenesis and oogenesis specific basic helix-loop-helix 1",TRUE
+"1555401_at",0.792243446641505,0.323140258375746,1.01055161125424,-5.45416368223883,0.721924192535328,"SOHLH2","spermatogenesis and oogenesis specific basic helix-loop-helix 2",TRUE
+"214988_s_at",0.689848451630875,0.158721518211703,-1.4585449511811,-4.95346351726854,-0.349164312471572,"SON","SON DNA binding protein",TRUE
+"201086_x_at",0.888773817669969,0.5556644793674,-0.598365071714941,-5.7667836750939,-0.149506552431053,"SON","SON DNA binding protein",TRUE
+"213538_at",0.964503386562183,0.836130077148121,-0.20929530822276,-5.91837040471201,-0.0645584867036462,"SON","SON DNA binding protein",TRUE
+"226465_s_at",0.968451827985008,0.852054724168147,-0.188688317387064,-5.92235729822623,-0.0618174275102881,"SON","SON DNA binding protein",TRUE
+"201085_s_at",0.969882914559333,0.856706177821985,-0.182685338086191,-5.92344132943566,-0.0468064665651564,"SON","SON DNA binding protein",TRUE
+"211705_s_at",0.654991908675739,0.123822521592546,1.59972775836733,-4.76462682143313,0.984350457016876,"SORBS1","sorbin and SH3 domain containing 1",TRUE
+"211819_s_at",0.774230543658252,0.286645794757672,1.0918128007673,-5.37517942151983,0.698922114084764,"SORBS1","sorbin and SH3 domain containing 1",TRUE
+"222513_s_at",0.876309093376839,0.525032158771623,0.645814588170779,-5.73855738676448,0.563187926414439,"SORBS1","sorbin and SH3 domain containing 1",TRUE
+"207436_x_at",0.91704891241952,0.648888036262429,0.461571733303902,-5.83644480705798,0.155512940222438,"SORBS1","sorbin and SH3 domain containing 1",TRUE
+"218087_s_at",0.968457469937034,0.852154008618213,0.188560111530953,-5.92238081492504,0.253580847110499,"SORBS1","sorbin and SH3 domain containing 1",TRUE
+"1555472_at",0.517710490281617,0.0368623125499101,2.22121217531536,-3.78579516330989,1.23701550434378,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"204288_s_at",0.601115828839805,0.0767465668795603,1.85638377786498,-4.38757684343877,1.63341384785094,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"238751_at",0.704331267592907,0.176209237370912,1.39713507417588,-5.03119239769412,1.79570054091982,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"225728_at",0.716280952967285,0.192074112750445,1.34549586554239,-5.09441099691087,1.98203736907034,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"227827_at",0.722937902375896,0.1993919649836,1.32280322729864,-5.12156165783153,1.86321989299323,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"1558815_at",0.737123149977386,0.222844622636529,1.25418762092229,-5.20127197356993,1.05890081208747,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"227826_s_at",0.755049574909504,0.248878433346218,1.18421028103339,-5.27879847233691,1.30484530832319,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"237285_at",0.885691916781033,0.547355174688876,0.611095469968306,-5.75941444891162,0.244296830439114,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"220858_at",0.898736771120062,0.588492856570848,-0.549004628497245,-5.79393642339702,-0.355562793177297,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"233720_at",0.978356576329994,0.895954527239923,-0.132282849093338,-5.93116407609199,-0.0838349090129498,"SORBS2","sorbin and SH3 domain containing 2",TRUE
+"209253_at",0.597654932724127,0.0741048862864866,1.87451286237799,-4.35940543413547,1.03806853856846,"SORBS3","sorbin and SH3 domain containing 3",TRUE
+"207788_s_at",0.659859296222732,0.127590900405427,1.58300531220623,-4.78771150801428,1.307255807584,"SORBS3","sorbin and SH3 domain containing 3",TRUE
+"1556891_at",0.724970327905974,0.202897198906383,1.31216345442643,-5.13415761665448,0.466298541086675,"SORCS1","sortilin related VPS10 domain containing receptor 1",TRUE
+"228194_s_at",0.962901358483638,0.831704072614883,0.215038808037458,-5.91718592325562,0.153840611329347,"SORCS1","sortilin related VPS10 domain containing receptor 1",TRUE
+"228720_at",0.789588280745252,0.31673068446831,1.02433635577007,-5.44115251608855,0.954693470493251,"SORCS2","sortilin related VPS10 domain containing receptor 2",TRUE
+"215522_at",0.948814396904806,0.767103641532328,-0.299827332747202,-5.89599284665879,-0.255568369723171,"SORCS3","sortilin related VPS10 domain containing receptor 3",TRUE
+"237425_at",0.585036027492332,0.0652184972481952,-1.93995900399579,-4.25611663102626,-1.02729545453429,"SORCS3-AS1","SORCS3 antisense RNA 1",TRUE
+"230782_at",0.929971640074599,0.690653835303688,0.403216089418694,-5.86080394950144,0.232452260842428,"SORD","sorbitol dehydrogenase",TRUE
+"201563_at",0.964552175124534,0.836203197689689,-0.20920048276722,-5.91838969264155,-0.128889084311814,"SORD","sorbitol dehydrogenase",TRUE
+"201562_s_at",0.978255630670068,0.89493477767422,-0.133587400012218,-5.93099528627308,-0.0805413088731921,"SORD","sorbitol dehydrogenase",TRUE
+"212560_at",0.87045636854107,0.509163952263183,-0.67098685473666,-5.72274370403417,-0.854808475721169,"SORL1","sortilin related receptor 1",TRUE
+"203509_at",0.946257232656659,0.756543353462666,-0.313886577397261,-5.89180929558553,-0.257880587876889,"SORL1","sortilin related receptor 1",TRUE
+"230707_at",0.94895689004559,0.768646670576341,0.29777827327017,-5.89658671348379,0.11731364534423,"SORL1","sortilin related receptor 1",TRUE
+"224818_at",0.785175995766517,0.31065481328281,-1.03758519100418,-5.42849722972875,-0.47780990841814,"SORT1","sortilin 1",TRUE
+"212807_s_at",0.826140850652187,0.394260571651988,-0.868818300461648,-5.57856564722803,-0.354995521760996,"SORT1","sortilin 1",TRUE
+"212797_at",0.884769004468037,0.544710930619067,-0.61516797006561,-5.75702541151816,-0.298220859557611,"SORT1","sortilin 1",TRUE
+"1557354_at",0.588370213314505,0.067031697462022,1.92599509567726,-4.27836110749693,0.983673435317886,"SOS1","SOS Ras/Rac guanine nucleotide exchange factor 1",TRUE
+"230337_at",0.630603891142543,0.101755393700236,1.7072354194051,-4.61178213419984,0.901806395304813,"SOS1","SOS Ras/Rac guanine nucleotide exchange factor 1",TRUE
+"212777_at",0.6936485676385,0.162681378084019,1.44417983328489,-4.97189080363695,0.537947991112,"SOS1","SOS Ras/Rac guanine nucleotide exchange factor 1",TRUE
+"212780_at",0.71557775024401,0.191320298805685,1.3478717604126,-5.09154594654808,0.610389972324361,"SOS1","SOS Ras/Rac guanine nucleotide exchange factor 1",TRUE
+"227426_at",0.931582451098271,0.698270621880939,0.392731562802006,-5.86483774375224,0.126964106346998,"SOS1","SOS Ras/Rac guanine nucleotide exchange factor 1",TRUE
+"229261_at",0.734577729521114,0.219030940257437,1.26495355247932,-5.18900473243398,0.930611999932482,"SOS1-IT1","SOS1 intronic transcript 1",TRUE
+"217644_s_at",0.661974206478491,0.129779604400865,-1.57348045944198,-4.80077544655573,-0.618341227075799,"SOS2","SOS Ras/Rho guanine nucleotide exchange factor 2",TRUE
+"212870_at",0.680997278535937,0.148971514568888,-1.49519418529671,-4.90578256615442,-0.591723387745642,"SOS2","SOS Ras/Rho guanine nucleotide exchange factor 2",TRUE
+"211665_s_at",0.771527793162888,0.280824908908305,-1.10544824746992,-5.36139162553642,-0.428546612596541,"SOS2","SOS Ras/Rho guanine nucleotide exchange factor 2",TRUE
+"238830_at",0.791211889207316,0.321554077468317,-1.01394501615624,-5.45097550761186,-0.581576245585253,"SOS2","SOS Ras/Rho guanine nucleotide exchange factor 2",TRUE
+"217576_x_at",0.842267796595011,0.435868770678724,-0.793559051520929,-5.637530485777,-0.29293795310207,"SOS2","SOS Ras/Rho guanine nucleotide exchange factor 2",TRUE
+"217575_s_at",0.91960407224049,0.658373533071074,-0.448182314749541,-5.84231912875897,-0.488334463986591,"SOS2","SOS Ras/Rho guanine nucleotide exchange factor 2",TRUE
+"223869_at",0.975398143273847,0.881520652645184,0.150770912708925,-5.92861768720931,0.205000809415962,"SOST","sclerostin",TRUE
+"213456_at",0.608709711882903,0.0813694489571216,1.82592636652632,-4.43446652861417,3.60792762866037,"SOSTDC1","sclerostin domain containing 1",TRUE
+"230238_at",0.712948021516228,0.187120755492958,-1.3612445623798,-5.07534108440133,-2.10257130576103,"SOWAHA","sosondowah ankyrin repeat domain family member A",TRUE
+"219496_at",0.93613089056626,0.71453705853611,0.370488218658001,-5.8730486945829,0.190572859140488,"SOWAHC","sosondowah ankyrin repeat domain family member C",TRUE
+"227034_at",0.97928472590149,0.899894348324277,0.127244879697103,-5.93180039094838,0.0659579196472908,"SOWAHC","sosondowah ankyrin repeat domain family member C",TRUE
+"230982_at",0.652139736047968,0.12129662704826,-1.61117568351207,-4.74871471181979,-1.04036160580076,"SOX1","SRY-box 1",TRUE
+"237472_at",0.714795139167042,0.190398477973827,1.35078721039333,-5.08802447376839,1.14822901682206,"SOX1","SRY-box 1",TRUE
+"208533_at",0.98529096111871,0.927009300688949,-0.0926563172599286,-5.93550281463934,-0.0286482910552193,"SOX1","SRY-box 1",TRUE
+"209842_at",0.906222238025079,0.612803841494491,0.513326392429761,-5.81214899349351,0.469447617427787,"SOX10","SRY-box 10",TRUE
+"209843_s_at",0.961212424803935,0.824297462784415,-0.224666834173365,-5.91512873836823,-0.135667958421079,"SOX10","SRY-box 10",TRUE
+"204915_s_at",0.789503009592599,0.316570819200341,-1.02468265478918,-5.44082359940308,-1.09871245831344,"SOX11","SRY-box 11",TRUE
+"204913_s_at",0.901788521024914,0.599523895345609,-0.532729126862787,-5.8023921865276,-0.682321813037654,"SOX11","SRY-box 11",TRUE
+"204914_s_at",0.990391782914487,0.951808618806433,0.0611238119501307,-5.93786391808462,0.085171200885986,"SOX11","SRY-box 11",TRUE
+"204432_at",0.571833476034523,0.0598910829441368,-1.98306518579868,-4.18675699081778,-0.853959135057926,"SOX12","SRY-box 12",TRUE
+"228358_at",0.99783553534859,0.989701293315881,0.0130543151010814,-5.93960047815706,0.00668384225124541,"SOX12","SRY-box 12",TRUE
+"38918_at",0.90360437116293,0.604816393773121,-0.524972084609473,-5.80633516206872,-0.267857460911809,"SOX13","SRY-box 13",TRUE
+"209736_at",0.931370027472813,0.696158139229088,-0.395634863024313,-5.86373121312124,-0.222212144738371,"SOX13","SRY-box 13",TRUE
+"1569111_at",0.99691938672319,0.984362427488194,-0.0198224609483697,-5.93949210086589,-0.0163495700163239,"SOX13","SRY-box 13",TRUE
+"208574_at",0.909052380289506,0.622734831209883,-0.498946408950203,-5.81915235755103,-0.215213022022253,"SOX14","SRY-box 14",TRUE
+"206122_at",0.0194042857965942,1.3131386821655e-05,5.56837227687743,3.14246530838554,5.34769070345927,"SOX15","SRY-box 15",TRUE
+"217040_x_at",0.411110107932987,0.0162519637828915,2.60107342918308,-3.09211397609312,0.658144702078101,"SOX15","SRY-box 15",TRUE
+"230943_at",0.916919564257648,0.648644076933833,0.461917220276155,-5.83629098957279,0.464991513687498,"SOX17","SRY-box 17",TRUE
+"219993_at",0.968035667633768,0.849192293011344,-0.19238597135504,-5.92167218596828,-0.208285728909319,"SOX17","SRY-box 17",TRUE
+"219568_x_at",0.65284137151906,0.122158603391337,1.60724682422803,-4.75418557200208,1.10827737939984,"SOX18","SRY-box 18",TRUE
+"228038_at",0.768852835478002,0.273265997634026,-1.12346477076515,-5.34294103504089,-1.38489511969331,"SOX2","SRY-box 2",TRUE
+"214178_s_at",0.854040699678541,0.463334954795963,0.746294606557851,-5.67199190037295,0.254009641121933,"SOX2","SRY-box 2",TRUE
+"213721_at",0.96290309385099,0.83175102544846,-0.2149778401906,-5.91719866428879,-0.181226111534617,"SOX2","SRY-box 2",TRUE
+"213722_at",0.985498770484702,0.929559714566838,-0.0894095606458477,-5.93579061415337,-0.0586853157001253,"SOX2","SRY-box 2",TRUE
+"231898_x_at",0.843475287501313,0.438427801623838,0.789080117183165,-5.64088172225842,0.825478280444607,"SOX2-OT","SOX2 overlapping transcript",TRUE
+"208468_at",0.968451827985008,0.851966369834325,0.188802411922451,-5.92233635656002,0.145431606486983,"SOX21","SRY-box 21",TRUE
+"237885_at",0.700061364939874,0.17193276650046,1.41168462448814,-5.01302453374654,1.20125889668034,"SOX21-AS1","SOX21 antisense RNA 1 (head to head)",TRUE
+"214633_at",0.886023097762234,0.548265275107328,-0.6096961995662,-5.76023176550812,-0.849434974248578,"SOX3","SRY-box 3",TRUE
+"1553802_a_at",0.94895689004559,0.768995140559674,-0.297315704308694,-5.89672021848011,-0.243108671648204,"SOX3","SRY-box 3",TRUE
+"1559235_a_at",0.614178202960275,0.0851947478534795,1.80183838961592,-4.4711553719367,1.26866407428521,"SOX30","SRY-box 30",TRUE
+"207678_s_at",0.635368778245437,0.106262473276894,1.68377871542747,-4.64577498959932,1.58849177570156,"SOX30","SRY-box 30",TRUE
+"213665_at",0.411110107932987,0.016061503688546,-2.60638345383428,-3.08201127374749,-1.6234603281258,"SOX4","SRY-box 4",TRUE
+"1567906_at",0.540483367247649,0.0450181912475057,2.12454476558581,-3.95204612535199,0.584232081000075,"SOX4","SRY-box 4",TRUE
+"201417_at",0.89748872632674,0.584222845583653,-0.555344959028126,-5.79057547250074,-0.363718595186276,"SOX4","SRY-box 4",TRUE
+"201418_s_at",0.93789466363241,0.725340868587467,-0.355819903505742,-5.87820492557101,-0.267247988762211,"SOX4","SRY-box 4",TRUE
+"201416_at",0.943464796017993,0.746171885979041,-0.327757547415863,-5.88749573918896,-0.291011182240167,"SOX4","SRY-box 4",TRUE
+"213668_s_at",0.995032257518762,0.976851421208543,0.0293459373738888,-5.93926403845952,0.0226079956573102,"SOX4","SRY-box 4",TRUE
+"238009_at",0.849935057946582,0.451436732476107,-0.766555080771516,-5.65746428095988,-0.449816904439363,"SOX5","SRY-box 5",TRUE
+"207336_at",0.862634144901168,0.485666778404738,-0.709084935057862,-5.69771057909076,-0.814408264926588,"SOX5","SRY-box 5",TRUE
+"1569638_at",0.958634572040512,0.812406637320478,0.240169956852802,-5.91162788248346,0.197167975670848,"SOX5","SRY-box 5",TRUE
+"238285_at",0.997608949249317,0.988042912711082,-0.015156582512836,-5.93957159225524,-0.011027896271445,"SOX5","SRY-box 5",TRUE
+"216561_x_at",0.683019114815084,0.15194123467312,1.48382984734641,-4.92066975994627,0.988022010575449,"SOX5P1","SRY-box 5 pseudogene 1",TRUE
+"227497_at",0.645072069975909,0.115496845775652,-1.6382360749478,-4.71075374082103,-1.23018053266911,"SOX6","SRY-box 6",TRUE
+"224178_s_at",0.73832073372558,0.225203015570947,1.24760029894987,-5.20873353920735,1.08740259204253,"SOX6","SRY-box 6",TRUE
+"223865_at",0.771527793162888,0.280796761733838,-1.10551467757917,-5.36132408096068,-0.699198999026714,"SOX6","SRY-box 6",TRUE
+"228214_at",0.867453710407724,0.500037285613539,-0.685663523026664,-5.71325644455283,-0.746208880896207,"SOX6","SRY-box 6",TRUE
+"1570486_at",0.901781358899845,0.598867916065231,0.533692872821766,-5.80189837514287,0.4564930373019,"SOX6","SRY-box 6",TRUE
+"235526_at",0.911393258378799,0.629492580365268,0.489222045621941,-5.82377822485921,0.267237436716704,"SOX6","SRY-box 6",TRUE
+"227498_at",0.956734254923335,0.804035442144082,0.251120201889408,-5.9090152095631,0.282718252991545,"SOX6","SRY-box 6",TRUE
+"1563454_at",0.971943273048675,0.865641962854554,-0.1711722203077,-5.92542263360392,-0.112201049950764,"SOX6","SRY-box 6",TRUE
+"228698_at",0.0681210092794308,0.000165748329828671,4.52262181979423,0.927872808301127,4.0131886124386,"SOX7","SRY-box 7",TRUE
+"224013_s_at",0.165626734753013,0.00135077739821035,3.66427483154377,-0.921637657799614,3.0563619250941,"SOX7","SRY-box 7",TRUE
+"226913_s_at",0.882185224252633,0.53971825791039,0.622886132166751,-5.7524557743136,0.773824257535875,"SOX8","SRY-box 8",TRUE
+"202935_s_at",0.908709061737317,0.620838807044611,0.501683519954368,-5.81783428594914,0.589192102710001,"SOX9","SRY-box 9",TRUE
+"202936_s_at",0.982243328340126,0.914571105071704,0.10850583279448,-5.93395066180313,0.118050921123015,"SOX9","SRY-box 9",TRUE
+"230419_at",0.870808709484996,0.510219856119157,0.669298421197341,-5.72382253707331,0.708220740163098,"SOX9-AS1","SOX9 antisense RNA 1",TRUE
+"1564466_at",0.98453870130544,0.924735647177378,0.0955516087642485,-5.93523751901813,0.0830830035829746,"SOX9-AS1","SOX9 antisense RNA 1",TRUE
+"214732_at",0.8552783609358,0.467632126872058,0.739053826200934,-5.67709443554268,0.214843714493643,"SP1","Sp1 transcription factor",TRUE
+"1553685_s_at",0.937842878751575,0.724972327288692,0.356318944621604,-5.8780328816128,0.137326544471964,"SP1","Sp1 transcription factor",TRUE
+"224760_at",0.983498417373669,0.919260532767451,-0.10252715482422,-5.93456485863922,-0.0313682574792207,"SP1","Sp1 transcription factor",TRUE
+"224754_at",0.990810941805126,0.954982040219258,0.0570940496785615,-5.93809591091661,0.016410234728804,"SP1","Sp1 transcription factor",TRUE
+"210985_s_at",0.553930058946379,0.0505891669805604,2.06723713840684,-4.04839001186,1.52132520054778,"SP100","SP100 nuclear antigen",TRUE
+"202863_at",0.579147493561207,0.0623253671655034,1.96296491262191,-4.21922825031973,1.25109195238475,"SP100","SP100 nuclear antigen",TRUE
+"202864_s_at",0.592584559127425,0.069712005199956,1.90594986639241,-4.3100986547581,1.13829229787221,"SP100","SP100 nuclear antigen",TRUE
+"210218_s_at",0.635821858586292,0.106767303452999,1.68120420715453,-4.6494842890196,0.841974162653575,"SP100","SP100 nuclear antigen",TRUE
+"237426_at",0.6642007803758,0.132274868946484,1.56278270504008,-4.81537434264884,0.940100248763196,"SP100","SP100 nuclear antigen",TRUE
+"210219_at",0.847553824593324,0.446386098454309,0.775252716051224,-5.65111491423175,0.604645669624893,"SP100","SP100 nuclear antigen",TRUE
+"223980_s_at",0.82209835047115,0.385946419019542,0.884458014700133,-5.56568809867823,0.44320151058922,"SP110","SP110 nuclear body protein",TRUE
+"208012_x_at",0.891653456393983,0.561518227422102,0.58945637506444,-5.77185149691829,0.280546268764422,"SP110","SP110 nuclear body protein",TRUE
+"208392_x_at",0.905462783815257,0.611672553229903,0.514971408646881,-5.81133546714553,0.246624463651854,"SP110","SP110 nuclear body protein",TRUE
+"209762_x_at",0.91876780831279,0.654457427178868,0.453699940397506,-5.83991892101088,0.201034103661456,"SP110","SP110 nuclear body protein",TRUE
+"209761_s_at",0.997529192253754,0.987458115635116,0.0158979242120672,-5.93956037921784,0.0071766354700884,"SP110","SP110 nuclear body protein",TRUE
+"207777_s_at",0.68041487556515,0.148149808853602,-1.4983712397113,-4.90160432782124,-0.747374584263831,"SP140","SP140 nuclear body protein",TRUE
+"223934_at",0.774230543658252,0.289800442835643,1.08450643505171,-5.38250470881344,0.71759298148952,"SP140L","SP140 nuclear body protein like",TRUE
+"214791_at",0.794620886196317,0.326647284843997,1.00308980026959,-5.46114014745174,0.968515637168806,"SP140L","SP140 nuclear body protein like",TRUE
+"1565588_at",0.89316156038085,0.567227114847636,-0.580814266579336,-5.77669740850033,-0.474012515172832,"SP140L","SP140 nuclear body protein like",TRUE
+"237795_s_at",0.695812999227098,0.165687882182062,1.43346032278263,-4.98554466366817,0.787550648224023,"SP2","Sp2 transcription factor",TRUE
+"211736_at",0.893334037681196,0.56794629069131,0.579728752437398,-5.77730119518405,0.325524192419201,"SP2","Sp2 transcription factor",TRUE
+"204367_at",0.947778780715578,0.762154177120794,-0.30640885597069,-5.8940580570464,-0.0912302705650578,"SP2","Sp2 transcription factor",TRUE
+"238953_at",0.835952408568777,0.416201090226035,0.828539968596656,-5.6107445460656,0.403980471665747,"SP2-AS1","SP2 antisense RNA 1",TRUE
+"213168_at",0.655548963436249,0.124068539155121,-1.59862319499429,-4.76615745378439,-0.423604005288063,"SP3","Sp3 transcription factor",TRUE
+"229217_at",0.705853136697393,0.178218334315068,1.39039666533184,-5.03955389694746,0.37977178802848,"SP3","Sp3 transcription factor",TRUE
+"232529_at",0.861659105448003,0.482521910968889,0.714263525011245,-5.69420614242818,0.289945865761124,"SP3","Sp3 transcription factor",TRUE
+"238035_at",0.917312913042515,0.650130322458116,-0.459813332705717,-5.83722593366825,-0.12923511234696,"SP3","Sp3 transcription factor",TRUE
+"227537_s_at",0.997674669021782,0.988637627154849,0.0144026775864946,-5.93958244628032,0.0107283495669908,"SP3","Sp3 transcription factor",TRUE
+"216403_at",0.970274748961658,0.858757982734763,0.180039556386799,-5.9239080194926,0.132026221512552,"SP3P","Sp3 transcription factor pseudogene",TRUE
+"236265_at",0.782013893500464,0.303637365251419,1.05311672457908,-5.41347514680729,0.368296612468205,"SP4","Sp4 transcription factor",TRUE
+"206663_at",0.908801761853008,0.621186138818927,0.501181819818017,-5.81807640936443,0.329659940557034,"SP4","Sp4 transcription factor",TRUE
+"235845_at",0.83171794972459,0.406430732056578,-0.846304615870964,-5.5967277316319,-0.718711875265219,"SP5","Sp5 transcription factor",TRUE
+"228975_at",0.898609426925686,0.588156514491066,0.549503218262875,-5.79367348324571,0.327581846060048,"SP6","Sp6 transcription factor",TRUE
+"1552340_at",0.82706053436911,0.395705455025255,0.866122209714885,-5.58076400572995,0.489110605023217,"SP7","Sp7 transcription factor",TRUE
+"239743_at",0.893600768892136,0.568534066313153,0.578842094022535,-5.77779356263789,0.355066073760979,"SP8","Sp8 transcription factor",TRUE
+"237449_at",0.973515224681688,0.872604351451911,0.162218149059107,-5.92687466870746,0.160474549258865,"SP8","Sp8 transcription factor",TRUE
+"205406_s_at",0.812302873476553,0.358296146709857,-0.938122289876186,-5.51988879302509,-0.70010738601837,"SPA17","sperm autoantigenic protein 17",TRUE
+"220982_s_at",0.891653456393983,0.561417045782665,-0.589609951126677,-5.7717647557984,-0.342412485467894,"SPACA1","sperm acrosome associated 1",TRUE
+"243621_at",0.896115372949367,0.577233396202866,0.565773290622075,-5.78496606691875,0.402907631574813,"SPACA3","sperm acrosome associated 3",TRUE
+"231054_at",0.973493137611142,0.872015602965612,-0.162974781055588,-5.9267549786838,-0.0816220490888728,"SPACA4","sperm acrosome associated 4",TRUE
+"232093_at",0.85334340854827,0.460700509463875,0.75075345636897,-5.66882632510393,0.489857414099525,"SPACA6","sperm acrosome associated 6",TRUE
+"227992_s_at",0.908709061737317,0.620880556366181,-0.501623208639043,-5.81786340504536,-0.197297546794726,"SPACA6","sperm acrosome associated 6",TRUE
+"231405_at",0.883426910069061,0.541528173588744,0.620083805492646,-5.75412127588996,0.391370136468569,"SPACA7","sperm acrosome associated 7",TRUE
+"239222_at",0.839508810008021,0.426161704737412,0.810698173995198,-5.62454199691414,0.364412967084148,"SPACA9","sperm acrosome associated 9",TRUE
+"220050_at",0.900967256835949,0.597151375459005,0.536217190502468,-5.80060083095407,0.175550276579829,"SPACA9","sperm acrosome associated 9",TRUE
+"210117_at",0.918373706340477,0.653299946558218,0.455333515678053,-5.83920277968496,0.187471877086644,"SPAG1","sperm associated antigen 1",TRUE
+"210884_s_at",0.953598821119146,0.786389824355191,0.27430716991864,-5.90310100293434,0.16497226890931,"SPAG11A","sperm associated antigen 11A",TRUE
+"207271_x_at",0.369594346221397,0.0110320616924247,2.7736946864981,-2.75874968277261,1.38249108220744,"SPAG11A///SPAG11B","sperm associated antigen 11A///sperm associated antigen 11B",TRUE
+"1553579_a_at",0.54295328972902,0.0456423694049073,2.11781639659923,-3.96344496060101,2.04046854594949,"SPAG11A///SPAG11B","sperm associated antigen 11A///sperm associated antigen 11B",TRUE
+"1553582_a_at",0.850536169066796,0.453351475349164,0.763273132542042,-5.65984255316834,0.252706291175267,"SPAG11A///SPAG11B","sperm associated antigen 11A///sperm associated antigen 11B",TRUE
+"211381_x_at",0.962555471240652,0.8298041198949,-0.217506582403317,-5.9166671898317,-0.14479449325614,"SPAG11A///SPAG11B","sperm associated antigen 11A///sperm associated antigen 11B",TRUE
+"1560174_at",0.528412182286162,0.0410487782748083,2.16941456047298,-3.8754488259131,1.48024973215966,"SPAG16","sperm associated antigen 16",TRUE
+"240898_at",0.701911663048518,0.173480976794301,-1.40638423137312,-5.01966104090746,-1.3184356455067,"SPAG16","sperm associated antigen 16",TRUE
+"219109_at",0.937113154905832,0.720641851973842,0.362189786212264,-5.87599103449074,0.439905020829439,"SPAG16","sperm associated antigen 16",TRUE
+"233516_s_at",0.691626147814603,0.161284561218769,1.44921448922765,-4.96544934122809,1.11340668100398,"SPAG17","sperm associated antigen 17",TRUE
+"219888_at",0.896229101808264,0.579426521960904,0.562494348075629,-5.78674072209199,0.320149686788604,"SPAG4","sperm associated antigen 4",TRUE
+"203145_at",0.962741248200658,0.83051975326998,0.216576912831597,-5.91686330087528,0.064801333758826,"SPAG5","sperm associated antigen 5",TRUE
+"231541_s_at",0.899998627338565,0.59449321209765,0.540133219538897,-5.79857613902993,0.217991855952881,"SPAG5-AS1","SPAG5 antisense RNA 1",TRUE
+"231542_at",0.960511640674753,0.820608979788554,-0.229469634505442,-5.91406902615293,-0.170497767407654,"SPAG5-AS1","SPAG5 antisense RNA 1",TRUE
+"210032_s_at",0.791988150120355,0.322777721977721,-1.01132617990405,-5.45343681117468,-1.09927939542276,"SPAG6","sperm associated antigen 6",TRUE
+"210033_s_at",0.90115698600215,0.597689177565541,0.53542592862972,-5.80100819447419,0.565970924737982,"SPAG6","sperm associated antigen 6",TRUE
+"200053_at",0.953564723226096,0.785883666215344,0.274974489378529,-5.90292311857383,0.104386045855589,"SPAG7","sperm associated antigen 7",TRUE
+"206816_s_at",0.906507435035949,0.614420324259569,0.510978336418458,-5.81330580491064,0.254685139387139,"SPAG8","sperm associated antigen 8",TRUE
+"206815_at",0.937623890519979,0.723507412601124,0.358303496509223,-5.87734635233189,0.162526986852259,"SPAG8","sperm associated antigen 8",TRUE
+"1554543_at",0.627092759817312,0.0987007402934605,1.72364058391839,-4.58779876717598,0.637863617692585,"SPAG9","sperm associated antigen 9",TRUE
+"212468_at",0.927461627729509,0.682224997604489,0.414872312767342,-5.85619658422177,0.21767324756433,"SPAG9","sperm associated antigen 9",TRUE
+"212470_at",0.940668681806864,0.7346076154694,0.343301656244901,-5.8824426183033,0.163683143933293,"SPAG9","sperm associated antigen 9",TRUE
+"206748_s_at",0.960364513710223,0.820182272987532,0.230025606652744,-5.91394491362061,0.136860584138573,"SPAG9","sperm associated antigen 9",TRUE
+"225339_at",0.986342822130003,0.934472255162686,0.083158485468493,-5.93631583788141,0.0464553989459553,"SPAG9","sperm associated antigen 9",TRUE
+"216989_at",0.783844746433788,0.306756883785025,1.0461813415868,-5.42020784333466,0.359087393118265,"SPAM1","sperm adhesion molecule 1",TRUE
+"210536_s_at",0.91671872326659,0.647498755025284,-0.463539950596582,-5.83556701032755,-0.340267880207544,"SPAM1","sperm adhesion molecule 1",TRUE
+"216972_at",0.954054753819891,0.789117432137296,-0.27071326963262,-5.90405163389083,-0.164637190450857,"SPAM1","sperm adhesion molecule 1",TRUE
+"1564491_at",0.931370027472813,0.69598634557005,-0.395871120331498,-5.86364081548359,-0.244171024135225,"SPANXA2-OT1","SPANXA2 overlapping transcript 1",TRUE
+"224032_x_at",0.731574335156004,0.215344441700974,1.27549806876664,-5.17690287858207,1.30096740271084,"SPANXA2///SPANXA1","SPANX family member A2///sperm protein associated with the nucleus, X-linked, family member A1",TRUE
+"220922_s_at",0.830635993561085,0.404329281417585,0.850160919008294,-5.59364833526243,1.2279969949664,"SPANXA2///SPANXB1///SPANXC///SPANXA1","SPANX family member A2///SPANX family member B1///SPANX family member C///sperm protein associated with the nucleus, X-linked, family member A1",TRUE
+"220217_x_at",0.88136517545868,0.538038804344983,0.625490963247305,-5.75090116355219,0.427317578101967,"SPANXA2///SPANXC///SPANXA1","SPANX family member A2///SPANX family member C///sperm protein associated with the nucleus, X-linked, family member A1",TRUE
+"220921_at",0.806649582904638,0.347782770420381,0.959253108045669,-5.50117491938108,0.96854530640924,"SPANXB1","SPANX family member B1",TRUE
+"200665_s_at",0.745510155593313,0.237146270258969,1.21502482910516,-5.24513427788117,2.7098394321969,"SPARC","secreted protein acidic and cysteine rich",TRUE
+"212667_at",0.782013893500464,0.303615366145943,1.05316581259141,-5.4134273509848,2.01765827585585,"SPARC","secreted protein acidic and cysteine rich",TRUE
+"200795_at",0.72806517869755,0.208243351466312,1.29620788347112,-5.15288535018887,0.709722330448027,"SPARCL1","SPARC like 1",TRUE
+"207724_s_at",0.627053909308516,0.0978481022996747,1.72829694424867,-4.58096027146643,0.570612653901712,"SPAST","spastin",TRUE
+"209748_at",0.733981824228023,0.218180666538602,1.26737342523978,-5.18623505596405,0.465116835309296,"SPAST","spastin",TRUE
+"221057_at",0.980019293742949,0.906129194514486,-0.119279024940828,-5.93275617198217,-0.110845961024805,"SPATA1","spermatogenesis associated 1",TRUE
+"237807_at",0.771158062322823,0.280195185955932,-1.10693561270947,-5.35987844454446,-1.02151138355426,"SPATA12","spermatogenesis associated 12",TRUE
+"225564_at",0.171206734275901,0.00148068420089813,-3.6263427146115,-1.00253993788861,-1.59762740823335,"SPATA13","spermatogenesis associated 13",TRUE
+"1556601_a_at",0.545864297007573,0.0471651783881786,-2.1017422475423,-3.99058355346575,-2.07989252381979,"SPATA13","spermatogenesis associated 13",TRUE
+"1562770_at",0.872540606821582,0.515814945491766,0.660384006649363,-5.72947527424331,0.310695691740982,"SPATA13","spermatogenesis associated 13",TRUE
+"1557470_at",0.974699750720383,0.876400812897389,-0.157341421605967,-5.92763277715148,-0.125946941765291,"SPATA13","spermatogenesis associated 13",TRUE
+"223876_at",0.698391916012681,0.169343999082763,1.42063334253793,-5.0017734613975,0.561230641822373,"SPATA16","spermatogenesis associated 16",TRUE
+"230763_at",0.668193690220211,0.134286461237123,-1.5542795223126,-4.82692247218215,-0.788046455121363,"SPATA17","spermatogenesis associated 17",TRUE
+"1552269_at",0.994098505325585,0.972831818732324,-0.034443622070408,-5.93910566354311,-0.0312987319169853,"SPATA17","spermatogenesis associated 17",TRUE
+"230723_at",0.990810941805126,0.956290615048391,0.0554326447633029,-5.93818695464503,0.0453436351104042,"SPATA18","spermatogenesis associated 18",TRUE
+"229331_at",0.993753494258002,0.970488666225991,-0.0374156453049839,-5.93900164921379,-0.0656026660307001,"SPATA18","spermatogenesis associated 18",TRUE
+"237662_at",0.871744769522775,0.513420586329887,-0.664192213245931,-5.72706933064108,-0.484175211383265,"SPATA19","spermatogenesis associated 19",TRUE
+"1559138_a_at",0.990810941805126,0.954315533807296,-0.0579403287371907,-5.93804850230341,-0.0319682038573204,"SPATA19","spermatogenesis associated 19",TRUE
+"204434_at",0.61760967235709,0.0877549889199778,-1.78623355168835,-4.49473486325649,-0.550063295526302,"SPATA2","spermatogenesis associated 2",TRUE
+"204433_s_at",0.7717895132349,0.281813619215871,-1.10311785229682,-5.36375883511953,-0.452869253767783,"SPATA2","spermatogenesis associated 2",TRUE
+"218164_at",0.396220771188728,0.0136247542737475,-2.680108680853,-2.94072080829071,-1.31638469388234,"SPATA20","spermatogenesis associated 20",TRUE
+"1570242_x_at",0.662575055303091,0.130338524012815,1.57106952437385,-4.80407239877702,0.79702881699438,"SPATA21","spermatogenesis associated 21",TRUE
+"1570241_at",0.692728103625751,0.162186646269421,1.44595903206809,-4.96961653968619,0.410267277822073,"SPATA21","spermatogenesis associated 21",TRUE
+"231114_at",0.812896635201594,0.361965973908871,-0.930844783445261,-5.52624532002933,-0.605665760575015,"SPATA22","spermatogenesis associated 22",TRUE
+"1558667_at",0.838682969007165,0.423883973569658,0.814754889661455,-5.62142957981158,0.62334204115658,"SPATA22","spermatogenesis associated 22",TRUE
+"1558668_s_at",0.882123307082787,0.539633090755531,0.623018121768026,-5.75237715079305,0.539773887387401,"SPATA22","spermatogenesis associated 22",TRUE
+"238027_at",0.429276772897071,0.0188241960221078,2.53455853130749,-3.21779058954414,0.881669044023319,"SPATA24","spermatogenesis associated 24",TRUE
+"1558641_at",0.739367922105944,0.227253344469667,1.24191609839214,-5.21514498161605,0.365642086971762,"SPATA24","spermatogenesis associated 24",TRUE
+"1553752_at",0.761748280722165,0.261079648376134,1.15329453911176,-5.31181384517658,0.296584333912752,"SPATA25","spermatogenesis associated 25",TRUE
+"214965_at",0.532405994061663,0.0418889764255294,-2.15959965283107,-3.89228950138882,-0.779312206729523,"SPATA2L","spermatogenesis associated 2 like",TRUE
+"240340_at",0.929126743655924,0.688312663113223,0.406447925796548,-5.85953944419118,0.307061926183414,"SPATA3","spermatogenesis associated 3",TRUE
+"240590_at",0.960029104619887,0.819094420478783,-0.23144334603552,-5.91362707184753,-0.126995494772639,"SPATA3-AS1","SPATA3 antisense RNA 1 (head to head)",TRUE
+"215935_at",0.682539393883246,0.15012189926425,1.49077024994436,-4.91158874628987,0.89559058101467,"SPATA31A5///SPATA31A3///SPATA31A1///SPATA31A6///SPATA31A7","SPATA31 subfamily A member 5///SPATA31 subfamily A member 3///SPATA31 subfamily A member 1///SPATA31 subfamily A member 6///SPATA31 subfamily A member 7",TRUE
+"215320_at",0.748438284778152,0.241301162000939,1.20398357350057,-5.2572829683102,0.858467972225962,"SPATA31C2","SPATA31 subfamily C member 2",TRUE
+"237378_at",0.943010360246042,0.744326073732031,0.330232977526188,-5.88670652475377,0.0963314944699567,"SPATA31D1///SPATA31D3///SPATA31D4","SPATA31 subfamily D member 1///SPATA31 subfamily D member 3///SPATA31 subfamily D member 4",TRUE
+"1563868_a_at",0.849935057946582,0.451842323803819,-0.765859179572314,-5.65796937303222,-0.26486505617201,"SPATA31E1","SPATA31 subfamily E member 1",TRUE
+"1559559_at",0.919354071504066,0.656601318591211,0.450677528409439,-5.84123725935072,0.258032422270557,"SPATA31E1","SPATA31 subfamily E member 1",TRUE
+"1553803_at",0.849935057946582,0.451752860750302,-0.766012645074658,-5.65785802348237,-0.267906885371987,"SPATA32","spermatogenesis associated 32",TRUE
+"1553804_a_at",0.873330973137109,0.518487953042167,0.6561441740212,-5.73213830423754,0.473828602198624,"SPATA32","spermatogenesis associated 32",TRUE
+"230811_at",0.859947009633611,0.478382960750735,-0.721109035523304,-5.68953643396018,-0.195650647712476,"SPATA33","spermatogenesis associated 33",TRUE
+"229660_at",0.877857073443889,0.529096353402037,0.639435001567803,-5.74247296087562,0.290316748572453,"SPATA33","spermatogenesis associated 33",TRUE
+"231178_at",0.962792962312845,0.830687378348127,0.216359181622028,-5.91690910977293,0.0643718673167735,"SPATA4","spermatogenesis associated 4",TRUE
+"1559298_a_at",0.861659105448003,0.483212589640212,-0.713124524947345,-5.69497900520908,-0.414372423071398,"SPATA41","spermatogenesis associated 41 (non-protein coding)",TRUE
+"231586_at",0.977254232093199,0.891272237608174,-0.138274809845268,-5.9303751597814,-0.119217100350959,"SPATA42","spermatogenesis associated 42 (non-protein coding)",TRUE
+"1559390_a_at",0.858994261239434,0.475415366862089,0.72603852072547,-5.68614752433946,0.440594030914474,"SPATA45","spermatogenesis associated 45",TRUE
+"241546_at",0.732505233366135,0.216851023452478,-1.27117214167816,-5.18187809156675,-0.753446413533656,"SPATA5","spermatogenesis associated 5",TRUE
+"229075_at",0.801086839730802,0.33745900039954,0.980429658285339,-5.48203842505147,0.48039997907614,"SPATA5","spermatogenesis associated 5",TRUE
+"242251_at",0.809543749841217,0.352778611744043,0.949158901592101,-5.51016220192526,0.373969445093158,"SPATA5","spermatogenesis associated 5",TRUE
+"215694_at",0.834444353959803,0.412620714287284,0.835018866103141,-5.60566470245797,0.342046111381833,"SPATA5L1","spermatogenesis associated 5 like 1",TRUE
+"222163_s_at",0.851319596585235,0.455096798502905,0.760288853975014,-5.66199674502318,0.248401561824497,"SPATA5L1","spermatogenesis associated 5 like 1",TRUE
+"218933_at",0.889452275006221,0.557361727835757,0.595777064364863,-5.76826346574157,0.232128132865771,"SPATA5L1","spermatogenesis associated 5 like 1",TRUE
+"220298_s_at",0.565956563686213,0.0568409741622364,-2.00929839778028,-4.14404340699153,-1.68816866160056,"SPATA6","spermatogenesis associated 6",TRUE
+"242086_at",0.737123149977386,0.222670119477051,-1.25467714643873,-5.20071613414922,-1.16907455202799,"SPATA6","spermatogenesis associated 6",TRUE
+"238459_x_at",0.949761528403753,0.772588352944307,0.292549811657663,-5.89808374919247,0.31571252498068,"SPATA6","spermatogenesis associated 6",TRUE
+"220299_at",0.992376456171815,0.96443058649327,-0.0451013009116701,-5.93869278088202,-0.0427737720143089,"SPATA6","spermatogenesis associated 6",TRUE
+"1554708_s_at",0.628076638668209,0.099448038600311,1.71958762872076,-4.59373988254934,1.17559520306469,"SPATA6L","spermatogenesis associated 6 like",TRUE
+"220218_at",0.703948341108555,0.175810052086645,1.39848120022513,-5.02951802470593,1.08261187337147,"SPATA6L","spermatogenesis associated 6 like",TRUE
+"1554707_at",0.873301865850313,0.518353699938963,0.656356832875865,-5.73200512552855,0.350259630804003,"SPATA6L","spermatogenesis associated 6 like",TRUE
+"237363_at",0.979733250157224,0.903307784918622,-0.122882744407963,-5.9323314204481,-0.127385906489937,"SPATA6L","spermatogenesis associated 6 like",TRUE
+"1555079_at",0.996203643989992,0.981044432668461,-0.0240291813785301,-5.93940225365209,-0.0150606361015453,"SPATA6L","spermatogenesis associated 6 like",TRUE
+"219583_s_at",0.588467901034655,0.0671289309328421,-1.92525570595591,-4.27953586391029,-0.897516453697646,"SPATA7","spermatogenesis associated 7",TRUE
+"234929_s_at",0.915353407558177,0.642911114633962,-0.470052612347354,-5.83263638218979,-0.199528289551165,"SPATA7","spermatogenesis associated 7",TRUE
+"231006_at",0.725181883744124,0.203826653601203,1.30936622910227,-5.1374548593721,0.416615942392796,"SPATA8","spermatogenesis associated 8",TRUE
+"223840_s_at",0.974536463688956,0.875700605470388,-0.158240572560244,-5.92749473580961,-0.121491389039416,"SPATA9","spermatogenesis associated 9",TRUE
+"223841_s_at",0.99886461451188,0.99495478768955,0.00639500739492239,-5.9396635617767,0.00517287640262598,"SPATA9","spermatogenesis associated 9",TRUE
+"241512_at",0.547095495716461,0.0475200093124366,-2.09806389670197,-3.99677524472992,-1.35399423942138,"SPATC1","spermatogenesis and centriole associated 1",TRUE
+"223360_at",0.822178297049143,0.386759796905992,0.882918358207998,-5.56696529173001,0.595697229966383,"SPATC1L","spermatogenesis and centriole associated 1-like",TRUE
+"239870_at",0.774230543658252,0.286975912623554,1.09104551916052,-5.37595074971223,0.431277627122094,"SPATS1","spermatogenesis associated serine rich 1",TRUE
+"218324_s_at",0.783884379328576,0.306886971001887,-1.0458932165607,-5.42048668280677,-0.445890038379797,"SPATS2","spermatogenesis associated serine rich 2",TRUE
+"222594_s_at",0.813631136157676,0.364326374887623,-0.926190044697804,-5.53028712702994,-0.308996522036249,"SPATS2","spermatogenesis associated serine rich 2",TRUE
+"1570130_at",0.920169584950428,0.660227788264493,-0.445574680747302,-5.84344344549298,-0.270154538848284,"SPATS2","spermatogenesis associated serine rich 2",TRUE
+"222593_s_at",0.922908550456534,0.669810207514528,-0.432148346893141,-5.84913045617906,-0.174739740884769,"SPATS2","spermatogenesis associated serine rich 2",TRUE
+"232961_at",0.659382629906731,0.127290016024655,1.58432529976983,-4.78589619730304,1.43810652839603,"SPATS2L","spermatogenesis associated serine rich 2 like",TRUE
+"222154_s_at",0.705100208997726,0.176864577146531,1.39493040669699,-5.03393178553207,2.03607879095169,"SPATS2L","spermatogenesis associated serine rich 2 like",TRUE
+"241812_at",0.726696341943087,0.20650226229151,1.30136887623582,-5.14684891519837,0.59009144121262,"SPATS2L","spermatogenesis associated serine rich 2 like",TRUE
+"215617_at",0.734042693548791,0.218377657580347,1.26681214659978,-5.18687787323251,1.55665888394073,"SPATS2L","spermatogenesis associated serine rich 2 like",TRUE
+"235572_at",0.877488742289724,0.527560293483409,0.64184301035964,-5.74099939525463,0.197487196844326,"SPC24","SPC24, NDC80 kinetochore complex component",TRUE
+"217183_at",0.899808883319249,0.592716641888711,0.542755246024996,-5.79721247546669,0.261465452025366,"SPC24","SPC24, NDC80 kinetochore complex component",TRUE
+"209891_at",0.947926063538122,0.762709782536122,-0.305669359513878,-5.89427752525201,-0.11103640440075,"SPC25","SPC25, NDC80 kinetochore complex component",TRUE
+"217927_at",0.700061364939874,0.171450581358193,-1.4133432061073,-5.01094363951229,-0.381728429190384,"SPCS1","signal peptidase complex subunit 1",TRUE
+"201240_s_at",0.848376789225697,0.448486337366486,-0.771628705832555,-5.65376869926867,-0.240056485994495,"SPCS2","signal peptidase complex subunit 2",TRUE
+"201239_s_at",0.862800800218883,0.486721386723867,-0.707352681478695,-5.69887740226405,-0.293004996089081,"SPCS2","signal peptidase complex subunit 2",TRUE
+"243570_at",0.958101903460289,0.810921329392379,0.242110639357145,-5.91117328836489,0.0851628349602871,"SPCS2","signal peptidase complex subunit 2",TRUE
+"218817_at",0.769847953580141,0.277575116687817,1.11315025152855,-5.3535364124188,0.451107454903445,"SPCS3","signal peptidase complex subunit 3",TRUE
+"221844_x_at",0.831957210365167,0.408223209621166,0.843025340544645,-5.59933607328265,0.270788333743848,"SPCS3","signal peptidase complex subunit 3",TRUE
+"222753_s_at",0.937856707467078,0.725152743275029,0.356074632142115,-5.87811713787289,0.17050289882002,"SPCS3","signal peptidase complex subunit 3",TRUE
+"214404_x_at",0.111201883761006,0.000551422351798525,-4.03207059614801,-0.13150139556411,-5.14979057103859,"SPDEF","SAM pointed domain containing ETS transcription factor",TRUE
+"220192_x_at",0.112518135066489,0.000572123572035382,-4.01700223925096,-0.164013576176189,-5.59751658856441,"SPDEF","SAM pointed domain containing ETS transcription factor",TRUE
+"213441_x_at",0.156242460469172,0.00118615349974071,-3.71787039870157,-0.8070930067363,-4.00318054387754,"SPDEF","SAM pointed domain containing ETS transcription factor",TRUE
+"214403_x_at",0.538232098912436,0.043806727757848,-2.13784723971123,-3.92944244622428,-0.821525723994274,"SPDEF","SAM pointed domain containing ETS transcription factor",TRUE
+"213442_x_at",0.822173415758858,0.386631163469573,0.883161709862799,-5.56676356122684,0.449105411539153,"SPDEF","SAM pointed domain containing ETS transcription factor",TRUE
+"1559222_at",0.606138724709726,0.0796828460970462,-1.83685994676015,-4.41769787724296,-0.616705215085375,"SPDL1","spindle apparatus coiled-coil protein 1",TRUE
+"221685_s_at",0.936456142259101,0.716422925187787,0.36792189986431,-5.87396565019717,0.134543488891955,"SPDL1","spindle apparatus coiled-coil protein 1",TRUE
+"238262_at",0.676475496596199,0.143489752755382,1.51666637038537,-4.87740572705138,0.86674192484034,"SPDYA","speedy/RINGO cell cycle regulator family member A",TRUE
+"217610_at",0.610033432202476,0.0821949430717086,1.82064649009765,-4.44253844918957,0.770252896439182,"SPDYE2","speedy/RINGO cell cycle regulator family member E2",TRUE
+"232964_at",0.731436100047755,0.214527833568647,1.27785258275429,-5.17418891047126,0.53097740826001,"SPDYE2B///SPDYE6///SPDYE5///SPDYE2///SPDYE1","speedy/RINGO cell cycle regulator family member E2B///speedy/RINGO cell cycle regulator family member E6///speedy/RINGO cell cycle regulator family member E5///speedy/RINGO cell cycle regulator family member E2///speedy/RINGO cell cycle regulator family member E1",TRUE
+"223498_at",0.751464513744428,0.244659787543136,1.19516243199026,-5.2669196417349,0.792532330386119,"SPECC1","sperm antigen with calponin homology and coiled-coil domains 1",TRUE
+"228900_at",0.854040699678541,0.463088147417442,0.746711689904529,-5.67169654802851,0.765911170576334,"SPECC1","sperm antigen with calponin homology and coiled-coil domains 1",TRUE
+"244461_at",0.89135210927217,0.560683708131476,0.590723457760694,-5.77113518388341,0.370758785478768,"SPECC1","sperm antigen with calponin homology and coiled-coil domains 1",TRUE
+"212480_at",0.96350209729653,0.833550290299247,-0.212642135867111,-5.91768407021673,-0.0798430195639899,"SPECC1L","sperm antigen with calponin homology and coiled-coil domains 1 like",TRUE
+"205013_s_at",0.885627706141628,0.547266898577066,-0.611231259023912,-5.75933503805536,-0.372445312091171,"SPECC1L-ADORA2A///ADORA2A","SPECC1L-ADORA2A readthrough (NMD candidate)///adenosine A2a receptor",TRUE
+"216119_s_at",0.774011928861764,0.285690684482162,-1.09403632929243,-5.37294143921623,-0.301182300207812,"SPEF1","sperm flagellar 1",TRUE
+"233429_at",0.76194182908399,0.261338731061949,-1.15264979884409,-5.31249421889951,-0.447425794061285,"SPEF2","sperm flagellar 2",TRUE
+"232745_x_at",0.971216837324271,0.861782184766928,-0.176142269293978,-5.92458310047128,-0.124155665019607,"SPEF2","sperm flagellar 2",TRUE
+"1552716_at",0.989768753740502,0.950649799479033,0.0625955911114433,-5.93777524626611,0.0416607318373314,"SPEF2","sperm flagellar 2",TRUE
+"240878_at",0.777826511138126,0.296868906690562,1.06834057612575,-5.3985563071013,0.518503972545203,"SPEM1","spermatid maturation 1",TRUE
+"201996_s_at",0.552420073963858,0.0499479354958163,2.07353644303206,-4.03788299140645,0.810288586104678,"SPEN","spen family transcriptional repressor",TRUE
+"1556058_s_at",0.768852835478002,0.273064486583563,1.12395001470143,-5.34244044821274,0.528514613266099,"SPEN","spen family transcriptional repressor",TRUE
+"201997_s_at",0.83176405048326,0.406639200992509,0.84592275603131,-5.59703194976634,0.237784423940665,"SPEN","spen family transcriptional repressor",TRUE
+"1556059_s_at",0.928075017557587,0.684006842014853,0.412403380752832,-5.85718326364064,0.138338525599339,"SPEN","spen family transcriptional repressor",TRUE
+"1553847_a_at",0.758436363256407,0.255466454646959,1.16738099123175,-5.29686555568244,0.36016964268318,"SPERT","spermatid associated",TRUE
+"1553846_at",0.929385267595748,0.689444541752955,-0.404884892961938,-5.86015224535638,-0.185516736569588,"SPERT","spermatid associated",TRUE
+"229352_at",0.248211697269269,0.00342298344290862,3.27693018653772,-1.73925059830957,4.35059434884516,"SPESP1","sperm equatorial segment protein 1",TRUE
+"1560214_at",0.776081330466781,0.293597919330131,1.07578674615194,-5.39118952623212,0.555955771902504,"SPG11","spastic paraplegia 11 (autosomal recessive)",TRUE
+"232403_at",0.840041055449124,0.428979653658948,-0.805697974064934,-5.62835821701204,-0.290860506511567,"SPG11","spastic paraplegia 11 (autosomal recessive)",TRUE
+"1559747_at",0.940355787532547,0.733434516754237,-0.344883239620443,-5.88191549736891,-0.155332311982408,"SPG11","spastic paraplegia 11 (autosomal recessive)",TRUE
+"203513_at",0.984132887597385,0.921979278999152,0.0990627185202482,-5.9349048546837,0.0511739898057364,"SPG11","spastic paraplegia 11 (autosomal recessive)",TRUE
+"241920_x_at",0.991150120855133,0.958555920264415,-0.0525569221038657,-5.9383381898807,-0.0339043083818726,"SPG11","spastic paraplegia 11 (autosomal recessive)",TRUE
+"236600_at",0.508488499910913,0.0335573660816144,2.26603231469196,-3.70718710345474,2.12750572363334,"SPG20","spastic paraplegia 20 (Troyer syndrome)",TRUE
+"212526_at",0.54756909892274,0.0480218350129774,2.09290361566129,-4.00544969706544,4.00374044521516,"SPG20","spastic paraplegia 20 (Troyer syndrome)",TRUE
+"230775_s_at",0.586715739386094,0.0661933558554811,1.93240950728247,-4.26815670816862,1.0101777408475,"SPG20","spastic paraplegia 20 (Troyer syndrome)",TRUE
+"216965_x_at",0.904381089098038,0.607216850406367,0.521464562073941,-5.80809957883483,0.335465386740408,"SPG20","spastic paraplegia 20 (Troyer syndrome)",TRUE
+"232605_s_at",0.817055852876968,0.369360649936415,0.916329225553645,-5.53878785421951,0.583020286470116,"SPG20-AS1","SPG20 antisense RNA 1",TRUE
+"217827_s_at",0.55937703282623,0.053377933108758,-2.04064559959275,-4.09251343555685,-0.586654165920438,"SPG21","spastic paraplegia 21 (autosomal recessive, Mast syndrome)",TRUE
+"215383_x_at",0.841967750949524,0.434810762266923,0.795415559309261,-5.63613617410953,0.25426945206852,"SPG21","spastic paraplegia 21 (autosomal recessive, Mast syndrome)",TRUE
+"238286_at",0.936143408699214,0.71475718964682,0.370188530217681,-5.87315609880743,0.215036346143368,"SPG7","SPG7, paraplegin matrix AAA peptidase subunit",TRUE
+"206272_at",0.810358506471539,0.354275251580964,-0.946153761658401,-5.51282097460361,-0.411318820489674,"SPHAR///RAB4A","S-phase response (cyclin related)///RAB4A, member RAS oncogene family",TRUE
+"203582_s_at",0.895026392624498,0.572473122569206,-0.572912061518973,-5.78106778639321,-0.272746633408598,"SPHAR///RAB4A","S-phase response (cyclin related)///RAB4A, member RAS oncogene family",TRUE
+"203581_at",0.90261448949227,0.601856636573487,-0.529306054549403,-5.80413910500246,-0.239024112816844,"SPHAR///RAB4A","S-phase response (cyclin related)///RAB4A, member RAS oncogene family",TRUE
+"219257_s_at",0.920835753388243,0.663434336738541,0.441072703169035,-5.84536938423597,0.307650836964205,"SPHK1","sphingosine kinase 1",TRUE
+"40273_at",0.50578136089344,0.0330545167237908,-2.27320211119834,-3.69452557139825,-0.802218290112814,"SPHK2","sphingosine kinase 2",TRUE
+"209857_s_at",0.74552004660471,0.237216502071919,-1.21483698654106,-5.2453417646816,-1.00201447016642,"SPHK2","sphingosine kinase 2",TRUE
+"228509_at",0.381806646015666,0.0120320594620026,2.73535325007543,-2.83364297119347,1.38329437476559,"SPHKAP","SPHK1 interactor, AKAP domain containing",TRUE
+"205312_at",0.841346844002252,0.431709314919345,-0.800873859000104,-5.63201902807021,-0.386844489042224,"SPI1","Spi-1 proto-oncogene",TRUE
+"205861_at",0.871744769522775,0.514131060927779,-0.663061182012955,-5.7277852762414,-0.484551476520131,"SPIB","Spi-B transcription factor",TRUE
+"232739_at",0.914242258486146,0.639546165171753,0.47484266391641,-5.83045536697465,0.341018189599646,"SPIB","Spi-B transcription factor",TRUE
+"1553851_at",0.784925710185113,0.310144696229916,1.03870580951107,-5.42742009189543,0.884162746269079,"SPIC","Spi-C transcription factor",TRUE
+"234995_at",0.902229953331547,0.600933485657082,-0.5306599218181,-5.80344948725203,-0.271545345569937,"SPICE1","spindle and centriole associated protein 1",TRUE
+"215094_at",0.912203172551256,0.631776818198416,-0.485945873624312,-5.82531666200439,-0.432047450634171,"SPICE1","spindle and centriole associated protein 1",TRUE
+"213003_s_at",0.670152406964446,0.135916354474986,1.54746667154369,-4.83613910329801,1.03814701172309,"SPIDR","scaffolding protein involved in DNA repair",TRUE
+"236284_at",0.84571977676742,0.443335035129671,-0.780535934430548,-5.6472251133965,-0.319049946645329,"SPIDR","scaffolding protein involved in DNA repair",TRUE
+"212523_s_at",0.846331475285199,0.444411095664162,-0.7786701056938,-5.64860168656038,-0.250166928686998,"SPIDR","scaffolding protein involved in DNA repair",TRUE
+"228325_at",0.944247754024473,0.750303783876949,0.32222377081491,-5.8892387563183,0.262022147413666,"SPIDR","scaffolding protein involved in DNA repair",TRUE
+"217813_s_at",0.718952781557655,0.194955536156814,1.33648105050225,-5.10524324572816,0.50218694704169,"SPIN1","spindlin 1",TRUE
+"222431_at",0.733934891101761,0.218027063785995,1.26781134949939,-5.1857333440581,0.390734073294727,"SPIN1","spindlin 1",TRUE
+"207841_at",0.627092759817312,0.0984867010595985,1.7248062419165,-4.58608813027933,1.25812161553089,"SPIN2A","spindlin family member 2A",TRUE
+"211704_s_at",0.398650588126476,0.0139347810959891,-2.67006887484724,-2.96007166749479,-0.896885930343219,"SPIN2B///SPIN2A","spindlin family member 2B///spindlin family member 2A",TRUE
+"1555883_s_at",0.673190784310977,0.138824437002401,-1.53547668422916,-4.85228171203177,-0.634500488016222,"SPIN3","spindlin family member 3",TRUE
+"1555882_at",0.757950630724418,0.254513068167108,-1.16979629384938,-5.29428650940311,-0.499732744695523,"SPIN3","spindlin family member 3",TRUE
+"1554099_a_at",0.768852835478002,0.27262157662749,-1.12501747425263,-5.3413385639334,-0.365966023277079,"SPIN3","spindlin family member 3",TRUE
+"1554098_at",0.842038788192302,0.435114729544683,-0.794881897070031,-5.63653728970434,-0.389770360151234,"SPIN3","spindlin family member 3",TRUE
+"228654_at",0.826134344333512,0.393762256211682,0.869749617144204,-5.57780478749,0.351138581321576,"SPIN4","spindlin family member 4",TRUE
+"206239_s_at",0.491182158425666,0.0294035519803787,2.32847434048466,-3.59613355142812,1.63452510306948,"SPINK1","serine peptidase inhibitor, Kazal type 1",TRUE
+"233340_at",0.827011327018402,0.395437715998941,0.866621318602684,-5.58035751777167,0.651963612716141,"SPINK13","serine peptidase inhibitor, Kazal type 13 (putative)",TRUE
+"206310_at",0.86481525165637,0.492495248708104,0.697906915870032,-5.70519207822947,0.572887443979564,"SPINK2","serine peptidase inhibitor, Kazal type 2",TRUE
+"207214_at",0.971216837324271,0.862116399948977,0.175711738828423,-5.92465677276655,0.156175171847974,"SPINK4","serine peptidase inhibitor, Kazal type 4",TRUE
+"205185_at",0.753862100951903,0.247233379846195,1.18846439926878,-5.27419572444729,1.17942191804534,"SPINK5","serine peptidase inhibitor, Kazal type 5",TRUE
+"1553973_a_at",0.280595655647765,0.00470610363473252,3.14219671411959,-2.01797616051936,1.80634512264991,"SPINK6","serine peptidase inhibitor, Kazal type 6",TRUE
+"223720_at",0.85334340854827,0.460935219907256,0.750355587788535,-5.66910951894652,0.505121613989776,"SPINK7","serine peptidase inhibitor, Kazal type 7 (putative)",TRUE
+"235546_at",0.843475287501313,0.438709113295005,0.788588734318623,-5.64124829866336,0.345056363336102,"SPINT1","serine peptidase inhibitor, Kunitz type 1",TRUE
+"202826_at",0.930899509890345,0.694351293450514,0.398120857866997,-5.86277734979926,0.401210380001963,"SPINT1","serine peptidase inhibitor, Kunitz type 1",TRUE
+"210715_s_at",0.982646305191608,0.915792955506802,-0.106947681393403,-5.93411408195715,-0.0417414146581976,"SPINT2","serine peptidase inhibitor, Kunitz type 2",TRUE
+"215503_at",0.732320150624823,0.216650642097952,-1.27174617140174,-5.18121873524709,-0.670378865537521,"SPINT3","serine peptidase inhibitor, Kunitz type 3",TRUE
+"224995_at",0.698480416742743,0.169807072690344,1.41902460630678,-5.00380040414071,0.718774425702827,"SPIRE1","spire type actin nucleation factor 1",TRUE
+"1559517_a_at",0.714791050845163,0.190231587056755,1.35131622435125,-5.0873848133401,0.722942164371695,"SPIRE1","spire type actin nucleation factor 1",TRUE
+"225018_at",0.719263304931448,0.195118671033255,1.33597380113777,-5.10585094265709,0.725148060142473,"SPIRE1","spire type actin nucleation factor 1",TRUE
+"1554807_a_at",0.79943091106207,0.334240390794991,0.987122467908312,-5.47591117804784,0.442948677982423,"SPIRE1","spire type actin nucleation factor 1",TRUE
+"227706_at",0.896118635245982,0.578171049780453,-0.564370639736592,-5.7857264449363,-0.223553749151638,"SPIRE2","spire type actin nucleation factor 2",TRUE
+"1568916_at",0.915580532396172,0.6442304281996,0.468177599111798,-5.83348422189079,0.411638630624248,"SPIRE2","spire type actin nucleation factor 2",TRUE
+"1569723_a_at",0.982243328340126,0.914514939328246,0.108577464130031,-5.93394309228625,0.0551429631775893,"SPIRE2","spire type actin nucleation factor 2",TRUE
+"243594_x_at",0.999503346640971,0.998845237441536,-0.00146369761993302,-5.93968243725989,-0.000671478160672478,"SPIRE2","spire type actin nucleation factor 2",TRUE
+"1568964_x_at",0.673580489720054,0.139724192668095,1.53180890782993,-4.85719990175092,0.706230577393226,"SPN","sialophorin",TRUE
+"206057_x_at",0.689848451630875,0.158796170859919,1.45827147097682,-4.95381571638424,0.719879053734084,"SPN","sialophorin",TRUE
+"206056_x_at",0.816800680706682,0.368734438349985,0.917550916042155,-5.53773921978883,0.28882368020397,"SPN","sialophorin",TRUE
+"216980_s_at",0.837368340567858,0.420362690428482,-0.821053335612391,-5.61656838991761,-0.526400563524028,"SPN","sialophorin",TRUE
+"216981_x_at",0.969882914559333,0.856893672612102,-0.182443510329495,-5.92348426729254,-0.068600015783356,"SPN","sialophorin",TRUE
+"223173_at",0.517859245504688,0.0369377676270791,-2.22023230532946,-3.78750314582374,-0.98922228697951,"SPNS1","sphingolipid transporter 1 (putative)",TRUE
+"225671_at",0.983567332578112,0.919839179277921,0.101789692554515,-5.93463821044772,0.0612219590806475,"SPNS2","sphingolipid transporter 2",TRUE
+"235900_at",0.98189652044177,0.913186212490966,-0.110272234891376,-5.93376254474514,-0.0940202373389312,"SPNS3","sphingolipid transporter 3 (putative)",TRUE
+"222259_s_at",0.752235383514782,0.245481347377786,1.19301852646893,-5.26925244378568,0.954664721041847,"SPO11","SPO11, initiator of meiotic double stranded breaks",TRUE
+"1562415_a_at",0.605664606439963,0.079224490203292,1.83986599281176,-4.41307499811845,1.99635796744071,"SPOCD1","SPOC domain containing 1",TRUE
+"235417_at",0.635821858586292,0.106839853390235,1.68083506817802,-4.65001578505996,1.71171024549264,"SPOCD1","SPOC domain containing 1",TRUE
+"202363_at",0.730101539866086,0.212740798418934,1.2830293131943,-5.16820686815259,1.84123469986254,"SPOCK1","sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1",TRUE
+"202524_s_at",0.0552282326235679,0.000103305691661576,4.71578555308717,1.34342805383649,2.98962931703586,"SPOCK2","sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2",TRUE
+"202523_s_at",0.226811031406261,0.00281107211606288,3.35966201792058,-1.56644509110911,2.67649481566892,"SPOCK2","sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2",TRUE
+"1554418_s_at",0.812302873476553,0.358339237483018,0.938036548347727,-5.51996394853464,0.653580204717663,"SPOCK3","sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3",TRUE
+"206434_at",0.835289077598304,0.414484121111692,-0.831642508342129,-5.60831658643299,-0.815508507050554,"SPOCK3","sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3",TRUE
+"206433_s_at",0.859947009633611,0.478343520039173,0.721174433241224,-5.68949161818623,0.563793352098312,"SPOCK3","sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3",TRUE
+"235342_at",0.952697366942815,0.78361131675036,-0.277971934457155,-5.90211881119694,-0.182080148356072,"SPOCK3","sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3",TRUE
+"209436_at",0.640839095542136,0.111314740857252,1.65846607424779,-4.68205784399604,0.883106021919565,"SPON1","spondin 1",TRUE
+"224488_s_at",0.704665987011002,0.176613185584172,1.39577535756216,-5.03288232271934,0.969179686357801,"SPON1","spondin 1",TRUE
+"213993_at",0.718706241731185,0.19466636557418,1.33738101173263,-5.10416459375082,1.4058578706116,"SPON1","spondin 1",TRUE
+"209437_s_at",0.767965891104819,0.270806059400501,1.12940636677438,-5.33679841843804,1.11209512912944,"SPON1","spondin 1",TRUE
+"213994_s_at",0.783297797848606,0.305897251583616,1.04808748536239,-5.41836139041812,1.48336649523965,"SPON1","spondin 1",TRUE
+"208927_at",0.703902004301726,0.175489029072628,-1.39956551698443,-5.02816833374352,-0.633627157020799,"SPOP","speckle type BTB/POZ protein",TRUE
+"204640_s_at",0.723655063748891,0.200403180130612,-1.31971891780921,-5.1252218713944,-0.526558747694761,"SPOP","speckle type BTB/POZ protein",TRUE
+"238923_at",0.742183223575327,0.232598253972807,-1.22727957320753,-5.23153800912764,-0.490455055311893,"SPOP","speckle type BTB/POZ protein",TRUE
+"225659_at",0.457302841869409,0.0226911503711488,-2.44903720903651,-3.37690205561374,-0.982661711027992,"SPOPL","speckle type BTB/POZ protein like",TRUE
+"225658_at",0.627092759817312,0.0989415598827163,-1.72233165511836,-4.58971863043094,-0.674835616864723,"SPOPL","speckle type BTB/POZ protein like",TRUE
+"222674_at",0.88020017258149,0.535367623867875,-0.629642969346767,-5.74841025813268,-0.196962563121621,"SPOUT1","SPOUT domain containing methyltransferase 1",TRUE
+"218565_at",0.925504446660705,0.677184242281493,-0.421871096068648,-5.85336812803421,-0.127561210150397,"SPOUT1","SPOUT domain containing methyltransferase 1",TRUE
+"209875_s_at",0.774230543658252,0.289696365657397,1.08474656822634,-5.38226465073858,1.44730243059767,"SPP1","secreted phosphoprotein 1",TRUE
+"1568574_x_at",0.957620703212172,0.809954891803692,-0.243373883298398,-5.91087542576821,-0.254187447913879,"SPP1","secreted phosphoprotein 1",TRUE
+"214478_at",0.715772127550152,0.191540228590513,1.34717781954056,-5.09238319548457,0.865190101275586,"SPP2","secreted phosphoprotein 2",TRUE
+"226353_at",0.733981824228023,0.218187591937413,-1.26735368638059,-5.18625766647699,-0.573718221636732,"SPPL2A","signal peptide peptidase like 2A",TRUE
+"227682_at",0.792611633508961,0.324231848427292,-1.00822304942003,-5.45634581444506,-0.453018619476236,"SPPL2A","signal peptide peptidase like 2A",TRUE
+"228478_at",0.877546037473893,0.527954991158139,-0.641223897312315,-5.74137876590742,-0.287892568592856,"SPPL2A","signal peptide peptidase like 2A",TRUE
+"210693_at",0.445496822354337,0.0208183700249718,-2.48860390445494,-3.30364524814797,-2.13131913826815,"SPPL2B","signal peptide peptidase like 2B",TRUE
+"225249_at",0.580152731323135,0.0627372288383418,-1.95963299854639,-4.22458912442502,-0.605337671455042,"SPPL2B","signal peptide peptidase like 2B",TRUE
+"225248_at",0.654038356341937,0.12318927622881,-1.60257932951728,-4.76067150074821,-0.737524935920479,"SPPL2B","signal peptide peptidase like 2B",TRUE
+"215833_s_at",0.839519981963042,0.427750068030856,-0.807877242587171,-5.62669769476956,-0.242161917282145,"SPPL2B","signal peptide peptidase like 2B",TRUE
+"231253_at",0.769258076576208,0.275716831425529,-1.1175839103747,-5.34899263254782,-0.584421882550319,"SPPL2C","signal peptide peptidase like 2C",TRUE
+"1566896_at",0.665148863268364,0.132628311062674,1.56128096275342,-4.817417457921,0.907309073805336,"SPPL3","signal peptide peptidase like 3",TRUE
+"224638_at",0.766390367856479,0.266999610917791,-1.13867868298912,-5.32715524906794,-0.414388348174619,"SPPL3","signal peptide peptidase like 3",TRUE
+"1554564_a_at",0.7768734672127,0.294864323946502,1.07289685379916,-5.3940540404929,0.79939038498901,"SPPL3","signal peptide peptidase like 3",TRUE
+"1566897_at",0.77938352158119,0.300644881538378,1.05981739427904,-5.406932378164,0.562421632689634,"SPPL3","signal peptide peptidase like 3",TRUE
+"1554565_x_at",0.821424121108148,0.383444587007231,0.889207099974359,-5.56173559421236,0.293722450539464,"SPPL3","signal peptide peptidase like 3",TRUE
+"224639_at",0.921797789017863,0.666709479393228,-0.436483960203135,-5.84731268643653,-0.166335749370678,"SPPL3","signal peptide peptidase like 3",TRUE
+"224640_at",0.959451355429682,0.816906441934997,-0.234296292863895,-5.91298158372327,-0.087957647753905,"SPPL3","signal peptide peptidase like 3",TRUE
+"203458_at",0.806221445484273,0.346976414756677,-0.960891574519906,-5.49970792053972,-0.320946879085254,"SPR","sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)",TRUE
+"244439_at",0.895583942835671,0.574790478575464,0.569433092047261,-5.78297347077818,0.568741455917826,"SPRED1","sprouty related EVH1 domain containing 1",TRUE
+"235074_at",0.922253982025599,0.668240098568729,0.43434270454029,-5.8482126664223,0.434602563322661,"SPRED1","sprouty related EVH1 domain containing 1",TRUE
+"226837_at",0.944139034486787,0.750199839309446,0.322362855386131,-5.88919530770214,0.250713795838772,"SPRED1","sprouty related EVH1 domain containing 1",TRUE
+"214026_s_at",0.586459015231188,0.0661060248901658,1.93308180874289,-4.26708581991741,0.704097186770476,"SPRED2","sprouty related EVH1 domain containing 2",TRUE
+"212466_at",0.821187434813103,0.382524891600969,-0.890957999878264,-5.56027343218746,-0.445759845360453,"SPRED2","sprouty related EVH1 domain containing 2",TRUE
+"212458_at",0.879006549665555,0.532628934438406,-0.63391151282001,-5.7458329063023,-0.269195231827966,"SPRED2","sprouty related EVH1 domain containing 2",TRUE
+"230046_at",0.943294768503521,0.745213095568541,-0.329043125395559,-5.88708660582424,-0.22938314097201,"SPRED3","sprouty related EVH1 domain containing 3",TRUE
+"238331_at",0.986342822130003,0.935000660185863,0.082486311058567,-5.93637005063397,0.0327953897792472,"SPRN","shadow of prion protein homolog (zebrafish)",TRUE
+"235715_at",0.865561991774564,0.495458946286993,0.69308311817541,-5.70838564019581,0.396645635915107,"SPRNP1","shadow of prion protein homolog (zebrafish) pseudogene 1",TRUE
+"214549_x_at",0.720952283360079,0.196960011638546,-1.33027127408777,-5.11266936303262,-0.425177071232945,"SPRR1A","small proline rich protein 1A",TRUE
+"213796_at",0.991689960875868,0.961549219280027,-0.0487577301484217,-5.9385256439885,-0.0558441693853444,"SPRR1A","small proline rich protein 1A",TRUE
+"205064_at",0.560295667354693,0.0542789915738176,2.03231873826361,-4.10625300963139,1.17209983431523,"SPRR1B","small proline rich protein 1B",TRUE
+"208539_x_at",0.924052586816455,0.673278150910053,0.427309221378914,-5.85113828171275,0.309306216183677,"SPRR2B","small proline rich protein 2B",TRUE
+"220664_at",0.765228531154075,0.265192835395702,1.14311391392092,-5.3225180525807,0.84647790682085,"SPRR2C","small proline rich protein 2C (pseudogene)",TRUE
+"236119_s_at",0.86481525165637,0.49257030536314,0.697784546815251,-5.70527335308527,0.641229626678331,"SPRR2G","small proline rich protein 2G",TRUE
+"232082_x_at",0.899808883319249,0.592640063122496,-0.542868354484976,-5.79715350559567,-0.49688272672369,"SPRR3","small proline rich protein 3",TRUE
+"218990_s_at",0.949217179291784,0.770800465333269,0.294920322293554,-5.89740827283188,0.251731862574625,"SPRR3","small proline rich protein 3",TRUE
+"1552620_at",0.907195796590196,0.616179663505688,-0.508426073654516,-5.81455735621855,-0.167727822100913,"SPRR4","small proline rich protein 4",TRUE
+"223511_at",0.647518308302168,0.118464808508607,-1.62424953355566,-4.73043527140283,-0.579091581245461,"SPRTN","SprT-like N-terminal domain",TRUE
+"212558_at",0.863569008901048,0.488848788159377,-0.703864887648586,-5.70121848359492,-0.514767355375556,"SPRY1","sprouty RTK signaling antagonist 1",TRUE
+"230212_at",0.955904644595647,0.800737267951805,-0.255443054663819,-5.90795192807365,-0.148040430364294,"SPRY1","sprouty RTK signaling antagonist 1",TRUE
+"204011_at",0.740610299769501,0.230299498827877,1.23354283290288,-5.22454361439759,1.72047061063539,"SPRY2","sprouty RTK signaling antagonist 2",TRUE
+"232157_at",0.544577979658206,0.0466631401956298,2.10698932900464,-3.98173922988974,0.670244743288514,"SPRY3","sprouty RTK signaling antagonist 3",TRUE
+"221489_s_at",0.70573152022539,0.177952774002947,-1.39128386283541,-5.03845491046478,-1.01357866073448,"SPRY4","sprouty RTK signaling antagonist 4",TRUE
+"1566967_at",0.708702460344186,0.180730469219552,1.38205555965456,-5.04985776305579,0.724936813773281,"SPRY4-IT1","SPRY4 intronic transcript 1",TRUE
+"1566968_at",0.841420204214686,0.432144169092707,-0.800107091576036,-5.63259899174597,-0.886422623338991,"SPRY4-IT1","SPRY4 intronic transcript 1",TRUE
+"225134_at",0.98672253748883,0.938063720402364,-0.078590604845766,-5.93667559122938,-0.0292835498712432,"SPRYD3","SPRY domain containing 3",TRUE
+"225616_at",0.800391590900314,0.336171787717143,-0.983101009832247,-5.47959736164983,-0.317812841746242,"SPRYD4","SPRY domain containing 4",TRUE
+"230151_at",0.7717895132349,0.281648956165789,-1.10350555194548,-5.36336531850448,-0.388247631959886,"SPRYD7","SPRY domain containing 7",TRUE
+"214668_at",0.994050962712312,0.972155809025175,0.0353010298810054,-5.93907653906554,0.0125183062519607,"SPRYD7","SPRY domain containing 7",TRUE
+"226075_at",0.787824125736409,0.313717546694707,1.03088414371305,-5.43491640314319,0.591991343967678,"SPSB1","splA/ryanodine receptor domain and SOCS box containing 1",TRUE
+"219677_at",0.892895911526563,0.566554091681381,0.581830757063639,-5.77613102308474,0.308731595352098,"SPSB1","splA/ryanodine receptor domain and SOCS box containing 1",TRUE
+"223580_at",0.954685039946564,0.793693799556856,-0.264691586594257,-5.90561653686263,-0.106895812661785,"SPSB2","splA/ryanodine receptor domain and SOCS box containing 2",TRUE
+"46256_at",0.948962238903406,0.769607531830641,-0.296502959081609,-5.89695429165697,-0.0981531783610468,"SPSB3","splA/ryanodine receptor domain and SOCS box containing 3",TRUE
+"221769_at",0.987967825391489,0.942455791605646,0.0730067745067196,-5.93708777296929,0.0241497453880601,"SPSB3","splA/ryanodine receptor domain and SOCS box containing 3",TRUE
+"229929_at",0.746766793112708,0.238656971837707,-1.21099352293292,-5.24958106786226,-0.938928761127734,"SPSB4","splA/ryanodine receptor domain and SOCS box containing 4",TRUE
+"206937_at",0.686998148149102,0.155551692553678,1.47025444347855,-4.93833333574527,0.857957634819543,"SPTA1","spectrin alpha, erythrocytic 1",TRUE
+"215235_at",0.769847953580141,0.277952017042964,1.1122536481005,-5.35445333911092,0.53498519084796,"SPTAN1","spectrin alpha, non-erythrocytic 1",TRUE
+"214926_at",0.773446505563834,0.284864747782577,1.0959634709803,-5.37099849191405,0.705636663922436,"SPTAN1","spectrin alpha, non-erythrocytic 1",TRUE
+"208611_s_at",0.817055852876968,0.369476888934387,0.91610260375398,-5.53898223276292,0.391773399253703,"SPTAN1","spectrin alpha, non-erythrocytic 1",TRUE
+"214925_s_at",0.877857073443889,0.529081102016114,0.639458891732399,-5.74245836758873,0.383446103291503,"SPTAN1","spectrin alpha, non-erythrocytic 1",TRUE
+"241150_at",0.926209999527899,0.679490667223475,-0.418666126848342,-5.85466914382677,-0.279535259342135,"SPTAN1","spectrin alpha, non-erythrocytic 1",TRUE
+"214145_s_at",0.268558783291603,0.0041413307337391,3.19646389418793,-1.90614291239516,2.03140549979056,"SPTB","spectrin beta, erythrocytic",TRUE
+"208416_s_at",0.835885356387511,0.415543880947771,0.829726580389208,-5.60981693984678,0.656777436413986,"SPTB","spectrin beta, erythrocytic",TRUE
+"213914_s_at",0.40221114169538,0.0145061976139838,2.65210381375583,-2.99461224617805,1.81701507588232,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"226765_at",0.412288520747647,0.0164312151204229,2.59612898094324,-3.10151203434515,1.42663643370432,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"212071_s_at",0.413716017977451,0.0166697098784513,2.58962823920823,-3.11385475787245,1.29063553440373,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"200672_x_at",0.432151440378733,0.0193078535516915,2.52300987177147,-3.23944280329179,1.26759026296563,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"230540_at",0.48580305784244,0.028270442228683,2.34691384968104,-3.5630057809854,1.57155873169001,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"200671_s_at",0.518537987260825,0.0371248045316775,2.21781124625719,-3.79172126277879,1.62080900064455,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"226342_at",0.547195868806649,0.0476419547334711,2.0968054456012,-3.99889197120174,2.2086536476993,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"215918_s_at",0.55937703282623,0.0538557055472752,2.03621493261507,-4.09982878342741,1.16050199112672,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"228246_s_at",0.62110896023334,0.0917241805364931,1.7627994824906,-4.52986309167961,1.30117668646371,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"242220_at",0.771011793494937,0.279901979508579,1.10762897572666,-5.3591724298014,0.42196762246558,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"214856_at",0.801560848966415,0.338574480136236,0.978120359187526,-5.48414377073767,0.6859279909001,"SPTBN1","spectrin beta, non-erythrocytic 1",TRUE
+"205155_s_at",0.640337040581689,0.11107612038068,1.65963954137721,-4.6803850490881,0.908282923693768,"SPTBN2","spectrin beta, non-erythrocytic 2",TRUE
+"224144_at",0.446963972064621,0.0210499899187264,2.48353506236124,-3.31306483231316,1.50536409679023,"SPTBN4","spectrin beta, non-erythrocytic 4",TRUE
+"220185_at",0.580630437263151,0.0629064816641444,-1.95826936200221,-4.22678135461461,-1.24582800858238,"SPTBN4","spectrin beta, non-erythrocytic 4",TRUE
+"224551_s_at",0.739340500562926,0.226640631238116,-1.24361063436103,-5.21323627922943,-0.41107161257356,"SPTBN4","spectrin beta, non-erythrocytic 4",TRUE
+"224145_s_at",0.967777603239069,0.848507699764892,-0.19327072550253,-5.92150629183908,-0.157597811096968,"SPTBN4","spectrin beta, non-erythrocytic 4",TRUE
+"224297_s_at",0.975398143273847,0.881770046870955,0.150451030358354,-5.92866456720248,0.080779604446267,"SPTBN4","spectrin beta, non-erythrocytic 4",TRUE
+"220067_at",0.986342822130003,0.934738165798694,-0.0828202205026162,-5.9363431748594,-0.0408948198046604,"SPTBN5","spectrin beta, non-erythrocytic 5",TRUE
+"1554053_at",0.673622120503302,0.139932651717791,-1.53096191530838,-4.85833432236421,-1.13110286156114,"SPTLC1","serine palmitoyltransferase long chain base subunit 1",TRUE
+"202277_at",0.951810226174863,0.779280124627115,-0.28369242617139,-5.90055980735672,-0.098861996132392,"SPTLC1","serine palmitoyltransferase long chain base subunit 1",TRUE
+"202278_s_at",0.953983577550391,0.78869700256874,0.271266989699163,-5.90390597930056,0.114417447200804,"SPTLC1","serine palmitoyltransferase long chain base subunit 1",TRUE
+"203127_s_at",0.724652102844753,0.202134047243142,-1.31446765154004,-5.13143706606282,-0.545230964087434,"SPTLC2","serine palmitoyltransferase long chain base subunit 2",TRUE
+"216202_s_at",0.737488397392592,0.223695640459436,-1.25180449262189,-5.20397527544956,-0.556026601200447,"SPTLC2","serine palmitoyltransferase long chain base subunit 2",TRUE
+"225095_at",0.819780516863333,0.37736618958027,-0.900830604731751,-5.55197909289199,-0.460442431287841,"SPTLC2","serine palmitoyltransferase long chain base subunit 2",TRUE
+"203128_at",0.895999830738594,0.576920068421201,-0.566242258242801,-5.78471143103497,-0.324599516707766,"SPTLC2","serine palmitoyltransferase long chain base subunit 2",TRUE
+"216203_at",0.955736115035547,0.798031456231863,-0.258993223901231,-5.9070652155354,-0.0805927001433551,"SPTLC2","serine palmitoyltransferase long chain base subunit 2",TRUE
+"220456_at",0.821962235882611,0.385109687703975,0.886044088992762,-5.56437024369397,0.738151942070642,"SPTLC3","serine palmitoyltransferase long chain base subunit 3",TRUE
+"236201_at",0.869441836317963,0.506590919175547,0.675109473051842,-5.72009860426002,0.595283394263456,"SPTLC3","serine palmitoyltransferase long chain base subunit 3",TRUE
+"227752_at",0.920147736488699,0.660012651144754,0.445877066254167,-5.84331339775949,0.625636824704116,"SPTLC3","serine palmitoyltransferase long chain base subunit 3",TRUE
+"213508_at",0.387357699611418,0.0127764453542913,-2.70872395901336,-2.8853823052306,-1.24401847734218,"SPTSSA","serine palmitoyltransferase small subunit A",TRUE
+"212460_at",0.683017520100356,0.151208135342565,-1.48661829246345,-4.91702538145579,-0.593361296212938,"SPTSSA","serine palmitoyltransferase small subunit A",TRUE
+"238702_at",0.771260048659834,0.280474870553333,-1.10627471640775,-5.36055103482694,-1.26474163861601,"SPTSSB","serine palmitoyltransferase small subunit B",TRUE
+"235440_at",0.861962516141708,0.484620243447214,0.710806079897255,-5.6965485463407,0.19176437502608,"SPTY2D1","SPT2 chromatin protein domain containing 1",TRUE
+"229594_at",0.957552213776939,0.808389484837969,-0.245420908613963,-5.91038948169122,-0.089472284494498,"SPTY2D1","SPT2 chromatin protein domain containing 1",TRUE
+"1558262_at",0.725143559947316,0.203285324965905,-1.31099416597197,-5.13553664473832,-0.779449483826328,"SPTY2D1-AS1","SPTY2D1 antisense RNA 1",TRUE
+"231404_at",0.901797819916539,0.599775141478714,0.532360138483521,-5.80258102167087,0.350439132395871,"SPTY2D1-AS1","SPTY2D1 antisense RNA 1",TRUE
+"229778_at",0.42510292927997,0.0180010682538311,2.55486590470606,-3.17959461530356,2.76187570362162,"SPX","spexin hormone",TRUE
+"221067_s_at",0.719675699464475,0.195563709411742,1.33459169286832,-5.1075057581095,0.368531397132088,"SPX","spexin hormone",TRUE
+"224167_at",0.480199164017157,0.0270422172109525,2.36768587496444,-3.52550993575253,1.52179033446035,"SPZ1","spermatogenic leucine zipper 1",TRUE
+"213577_at",0.825648186672984,0.393206804954211,-0.870788616026916,-5.5769550604312,-0.628521387959092,"SQLE","squalene epoxidase",TRUE
+"213562_s_at",0.887706911509597,0.552552014614492,-0.603121786301958,-5.76404768771659,-0.479594741037014,"SQLE","squalene epoxidase",TRUE
+"209218_at",0.897949253801113,0.586727100391752,-0.551623740024005,-5.79255259910087,-0.347373935418524,"SQLE","squalene epoxidase",TRUE
+"1557352_at",0.979588787486838,0.902818697766358,-0.123507611984421,-5.93225648637206,-0.0751773846934629,"SQLE","squalene epoxidase",TRUE
+"217995_at",0.782876787164404,0.305176078210254,1.04968954124809,-5.41680716644087,0.827965200227702,"SQRDL","sulfide quinone reductase-like (yeast)",TRUE
+"239004_at",0.436245613535646,0.0199073215504607,2.50906490541056,-3.26551974044878,1.07608804862017,"SQSTM1","sequestosome 1",TRUE
+"244804_at",0.683017520100356,0.151407363588398,1.48585941320593,-4.91801774997712,0.480194677644407,"SQSTM1","sequestosome 1",TRUE
+"213112_s_at",0.758966211371161,0.256528497231624,1.16469829085296,-5.29972465459357,0.669361982110662,"SQSTM1","sequestosome 1",TRUE
+"242568_s_at",0.843753336849204,0.439210787853492,0.787712911294363,-5.64190113800747,0.483640795004503,"SQSTM1","sequestosome 1",TRUE
+"201471_s_at",0.890280661109142,0.558576823021271,0.593926775541422,-5.76931763828675,0.168301314162264,"SQSTM1","sequestosome 1",TRUE
+"224864_at",0.554454260421586,0.0508162728871176,-2.06502323558447,-4.05207778549812,-0.769200819343906,"SRA1","steroid receptor RNA activator 1",TRUE
+"224130_s_at",0.580748061056528,0.0634719492608226,-1.95373687592529,-4.23406045863339,-0.780549602322473,"SRA1","steroid receptor RNA activator 1",TRUE
+"219055_at",0.768488057644313,0.27162380821173,1.12742685629541,-5.33884808220294,0.331948670981049,"SRBD1","S1 RNA binding domain 1",TRUE
+"1565082_x_at",0.668739504090464,0.135011530383815,1.55124039552465,-4.8310378440873,1.07301076847933,"SRC","SRC proto-oncogene, non-receptor tyrosine kinase",TRUE
+"1565080_at",0.690381347688918,0.160178059630206,1.45322777730193,-4.96030157349805,0.822130300060997,"SRC","SRC proto-oncogene, non-receptor tyrosine kinase",TRUE
+"1558210_at",0.829044392052913,0.400259148315983,-0.857666525716634,-5.58761742881858,-0.479274537256992,"SRC","SRC proto-oncogene, non-receptor tyrosine kinase",TRUE
+"221284_s_at",0.892746695408886,0.565612225648195,0.58325433043034,-5.77533620123447,0.521307604867531,"SRC","SRC proto-oncogene, non-receptor tyrosine kinase",TRUE
+"213324_at",0.929234395612144,0.688740491356332,0.405857008711555,-5.85977139179156,0.42682229314585,"SRC","SRC proto-oncogene, non-receptor tyrosine kinase",TRUE
+"221281_at",0.937531773202399,0.72313836194772,0.358803688489625,-5.87717272333444,0.225619702330124,"SRC","SRC proto-oncogene, non-receptor tyrosine kinase",TRUE
+"1558211_s_at",0.945498722604777,0.754078672176364,0.31717709210493,-5.89080272891105,0.108090779623474,"SRC","SRC proto-oncogene, non-receptor tyrosine kinase",TRUE
+"1569138_a_at",0.538039282264231,0.0437341788076082,2.13865434816673,-3.92806813457527,0.782599124073447,"SRCAP","Snf2-related CREBBP activator protein",TRUE
+"212275_s_at",0.614411830126793,0.0852766255639897,-1.8013331128161,-4.4719211961644,-0.608970368882887,"SRCAP","Snf2-related CREBBP activator protein",TRUE
+"1552630_a_at",0.626123824677003,0.097022803202178,-1.73283711220846,-4.57427920316353,-0.495706622307372,"SRCAP","Snf2-related CREBBP activator protein",TRUE
+"215053_at",0.899998627338565,0.594415955825507,0.540247161722151,-5.79851701340551,0.312870971947524,"SRCAP","Snf2-related CREBBP activator protein",TRUE
+"232547_at",0.819287552962377,0.376221484712811,-0.903033335414016,-5.55011696629994,-0.920011038901426,"SRCIN1","SRC kinase signaling inhibitor 1",TRUE
+"1554759_at",0.940193511330624,0.731899892326907,0.346953591094808,-5.88122185670632,0.250981018069582,"SRCIN1","SRC kinase signaling inhibitor 1",TRUE
+"236838_at",0.969882914559333,0.856671766343243,0.182729722667005,-5.92343344255004,0.11066818070904,"SRCIN1","SRC kinase signaling inhibitor 1",TRUE
+"210959_s_at",0.657015752622694,0.125963681137567,1.59017507884834,-4.77783708296384,0.768791753766957,"SRD5A1","steroid 5 alpha-reductase 1",TRUE
+"211056_s_at",0.718706241731185,0.194679541912639,1.33733998134356,-5.10421378414659,0.746432359472143,"SRD5A1","steroid 5 alpha-reductase 1",TRUE
+"204675_at",0.779229550249332,0.300398419105044,1.0603713765418,-5.40638978469532,0.601498231368529,"SRD5A1","steroid 5 alpha-reductase 1",TRUE
+"206938_at",0.51531387545335,0.0359839889751278,2.23275451544849,-3.76564176158509,0.763550467256046,"SRD5A2","steroid 5 alpha-reductase 2",TRUE
+"218800_at",0.269808928310707,0.00418962560833636,-3.19155157833001,-1.91629088252754,-2.12817375952138,"SRD5A3","steroid 5 alpha-reductase 3",TRUE
+"222750_s_at",0.274674111480702,0.00436643730884799,-3.17402327188171,-1.95246164606274,-1.52940938866646,"SRD5A3","steroid 5 alpha-reductase 3",TRUE
+"243444_at",0.345235484905341,0.00877059146837712,-2.87426155522863,-2.56018687685486,-1.26433362693383,"SRD5A3","steroid 5 alpha-reductase 3",TRUE
+"1568615_a_at",0.856631989847095,0.470736345525804,0.733847684682076,-5.68073400838844,0.261459681969679,"SRD5A3-AS1","SRD5A3 antisense RNA 1",TRUE
+"202308_at",0.714820080026392,0.190606568351586,-1.35012811250593,-5.08882113275631,-0.876540147027928,"SREBF1","sterol regulatory element binding transcription factor 1",TRUE
+"1558875_at",0.986145735582101,0.93200583813054,-0.0862964941616632,-5.93605693109438,-0.0479429819358055,"SREBF1","sterol regulatory element binding transcription factor 1",TRUE
+"242748_at",0.868220463162593,0.502244172260004,0.68210084812291,-5.71557746226829,0.220787219638982,"SREBF2","sterol regulatory element binding transcription factor 2",TRUE
+"201247_at",0.881875934621979,0.538851599887537,-0.624229774842811,-5.75165464403094,-0.221123439478276,"SREBF2","sterol regulatory element binding transcription factor 2",TRUE
+"201248_s_at",0.998347572104896,0.993076777199773,0.00877551563488621,-5.93964597224549,0.00379234210502943,"SREBF2","sterol regulatory element binding transcription factor 2",TRUE
+"242184_s_at",0.682539393883246,0.150323696618242,1.48999706617141,-4.9126020889603,0.769017026330541,"SREK1","splicing regulatory glutamic acid and lysine rich protein 1",TRUE
+"212721_at",0.755639383619058,0.249806709810964,-1.18181902137184,-5.28137937666556,-0.310635813357175,"SREK1","splicing regulatory glutamic acid and lysine rich protein 1",TRUE
+"242185_at",0.771008055264122,0.279560413376248,-1.10843736336161,-5.35834879618681,-0.567315185498772,"SREK1","splicing regulatory glutamic acid and lysine rich protein 1",TRUE
+"235611_at",0.937623890519979,0.723985304944261,0.357655924548212,-5.87757078520217,0.186292854306587,"SREK1","splicing regulatory glutamic acid and lysine rich protein 1",TRUE
+"1568783_at",0.942961933269639,0.744223023407187,-0.330371240850387,-5.88666227048932,-0.253232934507301,"SREK1","splicing regulatory glutamic acid and lysine rich protein 1",TRUE
+"243361_at",0.948109877411639,0.764319396233454,0.303527985286659,-5.89491007907412,0.256302718429331,"SREK1","splicing regulatory glutamic acid and lysine rich protein 1",TRUE
+"238781_at",0.953983577550391,0.788625652971897,0.271360968144104,-5.90388122918664,0.130500507903396,"SREK1","splicing regulatory glutamic acid and lysine rich protein 1",TRUE
+"244287_at",0.986672724664747,0.937792554141406,-0.0789354323224937,-5.93664914220686,-0.0283074220121335,"SREK1","splicing regulatory glutamic acid and lysine rich protein 1",TRUE
+"1553581_s_at",0.871744769522775,0.51358951667261,0.663923207824465,-5.72723971772918,0.236274732762048,"SREK1IP1","SREK1 interacting protein 1",TRUE
+"227288_at",0.886074884554245,0.54877082939451,-0.608919444817361,-5.76068468929865,-0.272269808379599,"SREK1IP1","SREK1 interacting protein 1",TRUE
+"235390_at",0.916565023170895,0.647286852760395,-0.463840319224435,-5.83543272845232,-0.20095800506436,"SREK1IP1","SREK1 interacting protein 1",TRUE
+"217608_at",0.945509858471469,0.754427961400932,-0.31671055107496,-5.89094607607421,-0.116716698484755,"SREK1IP1","SREK1 interacting protein 1",TRUE
+"202400_s_at",0.940227139261806,0.732933771347991,-0.345558622533651,-5.88168967132323,-0.113689445518974,"SRF","serum response factor",TRUE
+"202401_s_at",0.955904918346176,0.800809673158267,-0.255348101452783,-5.9079754771999,-0.104901018007796,"SRF","serum response factor",TRUE
+"241734_at",0.916349280948806,0.646679954079358,-0.46470082985192,-5.83504755957143,-0.176824623137749,"SRFBP1","serum response factor binding protein 1",TRUE
+"1555876_at",0.597654932724127,0.0747287269612088,1.87018137833255,-4.36615387019268,1.05003162244398,"SRGAP1","SLIT-ROBO Rho GTPase activating protein 1",TRUE
+"1569269_s_at",0.753624601581595,0.246893897824043,1.18934493619307,-5.27324122945283,0.558700826505442,"SRGAP1","SLIT-ROBO Rho GTPase activating protein 1",TRUE
+"227484_at",0.782148078497692,0.303932657992903,1.05245806331096,-5.41411627601347,0.606917930952321,"SRGAP1","SLIT-ROBO Rho GTPase activating protein 1",TRUE
+"233888_s_at",0.851771509132098,0.456817484449575,0.757353437979099,-5.66410787964711,0.425610858667271,"SRGAP1","SLIT-ROBO Rho GTPase activating protein 1",TRUE
+"1555875_at",0.936862206513955,0.717567052989207,-0.366366178672017,-5.87451845260132,-0.21689443156534,"SRGAP1","SLIT-ROBO Rho GTPase activating protein 1",TRUE
+"1554473_at",0.977874971442423,0.892734583790451,0.136402888362901,-5.93062536801279,0.120700273713133,"SRGAP1","SLIT-ROBO Rho GTPase activating protein 1",TRUE
+"1556202_at",0.832605695407954,0.409054969946326,0.841506778719132,-5.60054073790908,0.391923887162995,"SRGAP2","SLIT-ROBO Rho GTPase activating protein 2",TRUE
+"1556203_a_at",0.974982245454858,0.878581381238691,0.154542155350568,-5.92805750736578,0.126891856868525,"SRGAP2","SLIT-ROBO Rho GTPase activating protein 2",TRUE
+"228628_at",0.805746717966166,0.345757486297294,-0.963373289268729,-5.49748156160704,-0.370313164074366,"SRGAP2C","SLIT-ROBO Rho GTPase activating protein 2C",TRUE
+"1568957_x_at",0.924585344032373,0.674021447506947,-0.426273386849627,-5.85156517857464,-0.199333278054345,"SRGAP2C///SRGAP2B///SRGAP2","SLIT-ROBO Rho GTPase activating protein 2C///SLIT-ROBO Rho GTPase activating protein 2B///SLIT-ROBO Rho GTPase activating protein 2",TRUE
+"227649_s_at",0.928777626237599,0.686574420893256,-0.408850306545343,-5.858593038725,-0.168061743468245,"SRGAP2C///SRGAP2B///SRGAP2","SLIT-ROBO Rho GTPase activating protein 2C///SLIT-ROBO Rho GTPase activating protein 2B///SLIT-ROBO Rho GTPase activating protein 2",TRUE
+"1568955_at",0.953983577550391,0.788211372358304,-0.271906689096329,-5.90373734017309,-0.131198543869534,"SRGAP2C///SRGAP2B///SRGAP2","SLIT-ROBO Rho GTPase activating protein 2C///SLIT-ROBO Rho GTPase activating protein 2B///SLIT-ROBO Rho GTPase activating protein 2",TRUE
+"213329_at",0.978197434639598,0.894230351634191,0.134488700617647,-5.93087770529298,0.0464824975951377,"SRGAP2C///SRGAP2B///SRGAP2","SLIT-ROBO Rho GTPase activating protein 2C///SLIT-ROBO Rho GTPase activating protein 2B///SLIT-ROBO Rho GTPase activating protein 2",TRUE
+"232869_at",0.731546623601217,0.214774328341047,1.27714114171127,-5.17500941444965,0.690593811471144,"SRGAP3","SLIT-ROBO Rho GTPase activating protein 3",TRUE
+"215550_at",0.87754354850942,0.527837226429197,0.641408593757538,-5.74126562726069,0.410648844690952,"SRGAP3","SLIT-ROBO Rho GTPase activating protein 3",TRUE
+"1563595_at",0.925504446660705,0.677268982288898,0.421753263450409,-5.8534161333622,0.3122278313245,"SRGAP3","SLIT-ROBO Rho GTPase activating protein 3",TRUE
+"209794_at",0.954577684533304,0.792916260927758,0.265713977613156,-5.90535330388437,0.118768437121388,"SRGAP3","SLIT-ROBO Rho GTPase activating protein 3",TRUE
+"201859_at",0.598888818545127,0.0758209127017718,1.862673461675,-4.37782503860971,3.05328419396831,"SRGN","serglycin",TRUE
+"201858_s_at",0.627938764248877,0.0992704334800558,1.72054850745305,-4.59233230066695,2.64452452637321,"SRGN","serglycin",TRUE
+"1554676_at",0.971216837324271,0.862576998088763,0.175118459609175,-5.92475800007136,0.153180738655309,"SRGN","serglycin",TRUE
+"208921_s_at",0.626839388794963,0.0973437414813208,1.73106764891175,-4.57688460066811,0.852302807454178,"SRI","sorcin",TRUE
+"208920_at",0.750807729565285,0.243824729790182,1.19734710244817,-5.26453873433075,0.864308226536465,"SRI","sorcin",TRUE
+"235718_at",0.784925710185113,0.309812459989032,-1.0394363613477,-5.42671732211867,-0.38177928668586,"SRL","sarcalumenin",TRUE
+"201516_at",0.941106542715586,0.736047266766818,-0.341361922877082,-5.88308583523071,-0.179105604177545,"SRM","spermidine synthase",TRUE
+"234514_at",0.96696492045873,0.845881441489705,-0.19666631875153,-5.92086256696918,-0.157057831915383,"SRMS","src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites",TRUE
+"200007_at",0.842167419664876,0.435464397722264,-0.794268284102315,-5.63699818552509,-0.17696523567218,"SRP14","signal recognition particle 14",TRUE
+"205335_s_at",0.83030603167465,0.402571257298067,-0.853396868413902,-5.5910542421602,-0.268388703247272,"SRP19","signal recognition particle 19",TRUE
+"203605_at",0.624331975868069,0.0957638837226171,-1.7398267023109,-4.56396825572993,-0.52166090745672,"SRP54","signal recognition particle 54",TRUE
+"224607_s_at",0.940044918888428,0.731424259763955,-0.347595577290826,-5.88100593519418,-0.0980954907020255,"SRP68","signal recognition particle 68",TRUE
+"208263_at",0.725143559947316,0.203295211104838,1.31096440518185,-5.13557173026756,0.79938819649503,"SRP72","signal recognition particle 72",TRUE
+"208802_at",0.770807031642694,0.279344919487346,-1.10894774391484,-5.35782851537872,-0.386374798314563,"SRP72","signal recognition particle 72",TRUE
+"208803_s_at",0.946941640414848,0.759160901978213,-0.310395841609695,-5.89286574321328,-0.0940783624753365,"SRP72","signal recognition particle 72",TRUE
+"208095_s_at",0.951257505814081,0.777029930812303,-0.28666821396616,-5.89973635733791,-0.0869119158583622,"SRP72","signal recognition particle 72",TRUE
+"208800_at",0.961212424803935,0.822858095761452,-0.226540395140328,-5.91471800039195,-0.058750033420834,"SRP72","signal recognition particle 72",TRUE
+"208801_at",0.973515224681688,0.872611506743487,-0.16220895401045,-5.92687611983612,-0.0439875718842533,"SRP72","signal recognition particle 72",TRUE
+"201273_s_at",0.976371465776674,0.88707425088081,-0.143651409146976,-5.92963757410413,-0.0288118337042995,"SRP9","signal recognition particle 9",TRUE
+"202200_s_at",0.614411830126793,0.085377081621297,1.80071375907171,-4.47285970905784,0.677181454122112,"SRPK1","SRSF protein kinase 1",TRUE
+"202199_s_at",0.637485146909712,0.108903245575237,1.67042416495729,-4.6649692510177,0.561939509857853,"SRPK1","SRSF protein kinase 1",TRUE
+"1558254_s_at",0.647754107214051,0.118932899669232,-1.62207054329401,-4.73348978898697,-0.683216003281466,"SRPK2","SRSF protein kinase 2",TRUE
+"214931_s_at",0.725225714005638,0.203967778476417,-1.30894237719953,-5.13795395761539,-0.429523666696603,"SRPK2","SRSF protein kinase 2",TRUE
+"203182_s_at",0.785175995766517,0.310638190024786,-1.03762168829094,-5.42846216505698,-0.430264162804823,"SRPK2","SRSF protein kinase 2",TRUE
+"230091_at",0.886023097762234,0.548315056208323,-0.609619697023002,-5.76027639868329,-0.255808130527077,"SRPK2","SRSF protein kinase 2",TRUE
+"203181_x_at",0.910263605770897,0.627020538098647,-0.49277370552062,-5.82209901335751,-0.229482611628155,"SRPK2","SRSF protein kinase 2",TRUE
+"217517_x_at",0.919779587325098,0.658843123145864,-0.447521633700494,-5.84260459902347,-0.258027987800227,"SRPK2","SRSF protein kinase 2",TRUE
+"206216_at",0.820536502908875,0.379918261657473,-0.89593549989071,-5.55610222052122,-0.554297156452906,"SRPK3","SRSF protein kinase 3",TRUE
+"200918_s_at",0.711977799428804,0.185808391617964,-1.365472102522,-5.07019046678469,-0.472366788825298,"SRPRA","SRP receptor alpha subunit",TRUE
+"200917_s_at",0.839088939498165,0.424930040745499,-0.812890123167069,-5.62286208665406,-0.386635561085603,"SRPRA","SRP receptor alpha subunit",TRUE
+"218140_x_at",0.774230543658252,0.289068781193535,-1.08619588681698,-5.38081477906915,-0.341350667683935,"SRPRB","SRP receptor beta subunit",TRUE
+"227737_at",0.778686132916778,0.299375728844041,-1.06267357953472,-5.40413218771954,-0.35774413154533,"SRPRB","SRP receptor beta subunit",TRUE
+"222532_at",0.821424121108148,0.383056351117464,-0.889945880835473,-5.56111896928121,-0.395199152867002,"SRPRB","SRP receptor beta subunit",TRUE
+"204955_at",0.71278153948281,0.186822456109605,1.3622034186043,-5.0741740312068,1.65335082079368,"SRPX","sushi repeat containing protein, X-linked",TRUE
+"205499_at",0.0681210092794308,0.000174476204038437,4.5016774364689,0.882716551492588,3.7424747399456,"SRPX2","sushi repeat containing protein, X-linked 2",TRUE
+"216639_at",0.459111781250135,0.022943090353545,2.44394777778045,-3.38627940841855,0.965532763265339,"SRPX2","sushi repeat containing protein, X-linked 2",TRUE
+"235677_at",0.432151440378733,0.0193644105542621,2.52167709911533,-3.2419383015287,0.7398611202872,"SRR","serine racemase",TRUE
+"219204_s_at",0.536422380101288,0.0432923203033842,2.14359627596267,-3.91964609823325,0.966970037592862,"SRR","serine racemase",TRUE
+"219205_at",0.736462193466674,0.221984517738891,1.2566032795116,-5.19852727032827,0.592353488826385,"SRR","serine racemase",TRUE
+"222844_s_at",0.786455312223125,0.311983042435671,1.03467342980476,-5.43129111567554,0.518790129717347,"SRR","serine racemase",TRUE
+"213608_s_at",0.778397054392363,0.298283137023201,-1.06513934408995,-5.40170933269169,-0.35846507923932,"SRRD","SRR1 domain containing",TRUE
+"227615_at",0.943988850936011,0.749167147359163,0.323745017111779,-5.88876252553472,0.115658283380215,"SRRD","SRR1 domain containing",TRUE
+"201225_s_at",0.932249295738588,0.701166985153339,0.388756504286843,-5.86633972791125,0.106972957056493,"SRRM1","serine and arginine repetitive matrix 1",TRUE
+"201224_s_at",0.960031906173606,0.819140461051383,0.231383334036015,-5.91364056526712,0.0661710185944049,"SRRM1","serine and arginine repetitive matrix 1",TRUE
+"1554671_a_at",0.740476003158683,0.229480294383451,-1.23578633881535,-5.22203074695025,-0.598200187263416,"SRRM2","serine/arginine repetitive matrix 2",TRUE
+"207435_s_at",0.807528762746328,0.348755035015763,-0.957280954341193,-5.50293764748337,-0.345070751097525,"SRRM2","serine/arginine repetitive matrix 2",TRUE
+"216629_at",0.951879312464239,0.779477781479265,0.283431158542116,-5.90063169732625,0.235266961779875,"SRRM2","serine/arginine repetitive matrix 2",TRUE
+"208610_s_at",0.989524702314661,0.948809093086975,0.0649337057598025,-5.93763004316489,0.0270500563560407,"SRRM2","serine/arginine repetitive matrix 2",TRUE
+"1562930_at",0.822010986888098,0.385546059100032,0.885216640425651,-5.56505803637908,0.607051440155791,"SRRM2-AS1","SRRM2 antisense RNA 1",TRUE
+"1558725_at",0.762778023494851,0.262382881807611,1.150056153143,-5.31522783151638,0.767970676774943,"SRRM3","serine/arginine repetitive matrix 3",TRUE
+"1569074_at",0.822010986888098,0.385455572136507,-0.885388171750362,-5.56491550486388,-0.368828411414733,"SRRM3","serine/arginine repetitive matrix 3",TRUE
+"235880_at",0.901788521024914,0.59970453134775,0.532463831298252,-5.80252796823313,0.348373725468467,"SRRM3","serine/arginine repetitive matrix 3",TRUE
+"236151_at",0.822178297049143,0.386780941534541,0.882878361371526,-5.56699844285698,0.549351753300588,"SRRM4","serine/arginine repetitive matrix 4",TRUE
+"237828_at",0.839519981963042,0.427041447865088,0.809134943617912,-5.62573745670165,0.607299100858208,"SRRM4","serine/arginine repetitive matrix 4",TRUE
+"230010_at",0.931732479228723,0.698556521052471,0.392338900355279,-5.8649867822223,0.316501463879655,"SRRM4","serine/arginine repetitive matrix 4",TRUE
+"1565849_a_at",0.776936981479994,0.295255416439276,-1.07200619111786,-5.39493549277217,-0.788668826173439,"SRRM5","serine/arginine repetitive matrix 5",TRUE
+"222046_at",0.748184017928985,0.240474337093562,1.20616930536546,-5.25488564600739,0.343638330724153,"SRRT","serrate, RNA effector molecule",TRUE
+"214127_s_at",0.810358506471539,0.354272684931989,0.946158907948376,-5.51281642807295,0.28785422184638,"SRRT","serrate, RNA effector molecule",TRUE
+"222047_s_at",0.893635011091274,0.569076913981393,-0.578023625316064,-5.77824741625914,-0.134041159505422,"SRRT","serrate, RNA effector molecule",TRUE
+"201680_x_at",0.951810226174863,0.779298797820104,0.28366774262893,-5.90056660205095,0.0671952244223917,"SRRT","serrate, RNA effector molecule",TRUE
+"201679_at",0.997608949249317,0.988136037051532,0.0150385304854245,-5.93957332841863,0.00485762132780287,"SRRT","serrate, RNA effector molecule",TRUE
+"229246_at",0.639705117673934,0.110119023843714,-1.66436774586261,-4.67363579266336,-0.961263068653178,"SRSF1","serine and arginine rich splicing factor 1",TRUE
+"226419_s_at",0.730819267705703,0.213438434706989,-1.28100440630178,-5.17054923130777,-0.914060291643837,"SRSF1","serine and arginine rich splicing factor 1",TRUE
+"239384_at",0.774230543658252,0.289167491670373,-1.08596777874155,-5.38104308866602,-0.653112023983764,"SRSF1","serine and arginine rich splicing factor 1",TRUE
+"208863_s_at",0.89102917330053,0.560252417370382,-0.591378685648108,-5.77076418408672,-0.160040280527966,"SRSF1","serine and arginine rich splicing factor 1",TRUE
+"227164_at",0.930899509890345,0.693989209304885,0.398619347311529,-5.86258537372218,0.114738773276166,"SRSF1","serine and arginine rich splicing factor 1",TRUE
+"201742_x_at",0.940323871449272,0.733319539565197,-0.34503830121388,-5.88186368844942,-0.106190370047868,"SRSF1","serine and arginine rich splicing factor 1",TRUE
+"211784_s_at",0.969882914559333,0.856647898685102,-0.182760507847782,-5.92342797107817,-0.0406793003206349,"SRSF1","serine and arginine rich splicing factor 1",TRUE
+"201741_x_at",0.992179245947777,0.963589893259991,-0.0461680657333791,-5.93864536373918,-0.0205078173602677,"SRSF1","serine and arginine rich splicing factor 1",TRUE
+"210178_x_at",0.873230718105642,0.517756902084775,0.657302537911391,-5.73141237149696,0.199279890174845,"SRSF10","serine and arginine rich splicing factor 10",TRUE
+"213594_x_at",0.900967256835949,0.597144879579669,-0.536226749929306,-5.80059590591937,-0.170573860164325,"SRSF10","serine and arginine rich splicing factor 10",TRUE
+"225348_at",0.92710559339757,0.681538072647946,0.415824819251701,-5.85581437788648,0.119599452896699,"SRSF10","serine and arginine rich splicing factor 10",TRUE
+"204299_at",0.955892698633978,0.799698688799093,-0.256805326653662,-5.90761311636902,-0.0653943103522039,"SRSF10","serine and arginine rich splicing factor 10",TRUE
+"206095_s_at",0.998347572104896,0.992698336039127,0.0092552218289368,-5.93964175943068,0.00230852408589932,"SRSF10","serine and arginine rich splicing factor 10",TRUE
+"236948_x_at",0.854040699678541,0.463074869343546,0.746734132466707,-5.67168065117643,0.541120777364565,"SRSF11","serine and arginine rich splicing factor 11",TRUE
+"200685_at",0.861659105448003,0.482458366977411,0.714368363126583,-5.69413494604326,0.340192228421172,"SRSF11","serine and arginine rich splicing factor 11",TRUE
+"213742_at",0.907189812622248,0.616078680082731,0.508572477012517,-5.81448572975138,0.341576544568393,"SRSF11","serine and arginine rich splicing factor 11",TRUE
+"200686_s_at",0.972405051071295,0.866880829846363,0.169577932629676,-5.92568686276178,0.046214099289104,"SRSF11","serine and arginine rich splicing factor 11",TRUE
+"239295_at",0.554591730312003,0.050879416904344,2.06440926012245,-4.05310004958241,1.1222085606617,"SRSF12","serine and arginine rich splicing factor 12",TRUE
+"1552381_at",0.976371465776674,0.886888133207615,-0.143889879803799,-5.92960420934982,-0.156881051887864,"SRSF12","serine and arginine rich splicing factor 12",TRUE
+"237485_at",0.740610299769501,0.230374228340082,1.23333847772359,-5.22477230941761,0.448324675763177,"SRSF3","serine and arginine rich splicing factor 3",TRUE
+"232392_at",0.822850703882235,0.388484464938566,0.879660675131064,-5.56966083833827,0.508039383376271,"SRSF3","serine and arginine rich splicing factor 3",TRUE
+"208673_s_at",0.931370027472813,0.696728006085557,-0.394851323993691,-5.86403063320945,-0.103752543124802,"SRSF3","serine and arginine rich splicing factor 3",TRUE
+"208672_s_at",0.948668195792872,0.766463955445059,-0.300677185283962,-5.89574535440929,-0.0672045845495415,"SRSF3","serine and arginine rich splicing factor 3",TRUE
+"202899_s_at",0.956938436670832,0.804685899668554,-0.250268239561474,-5.9092226369751,-0.0773461966837878,"SRSF3","serine and arginine rich splicing factor 3",TRUE
+"235324_at",0.975398143273847,0.88242779654086,0.149607453059937,-5.92878772023301,0.0647466162895816,"SRSF3","serine and arginine rich splicing factor 3",TRUE
+"241245_at",0.716472449896956,0.192251001900153,1.34493940251733,-5.09508141392729,1.24292581048594,"SRSF4","serine and arginine rich splicing factor 4",TRUE
+"239512_at",0.751464513744428,0.244569174050597,1.19539922330746,-5.26666176354591,0.698079063597664,"SRSF4","serine and arginine rich splicing factor 4",TRUE
+"242837_at",0.763792735179544,0.263789633624057,1.14657383344733,-5.31888955863187,0.541473440244978,"SRSF4","serine and arginine rich splicing factor 4",TRUE
+"201696_at",0.76912869907427,0.275015582991828,1.11926267059967,-5.34726800070461,0.311028645974838,"SRSF4","serine and arginine rich splicing factor 4",TRUE
+"239511_s_at",0.866000265112326,0.4965068186644,0.691381517254336,-5.70950712864413,0.350571355790572,"SRSF4","serine and arginine rich splicing factor 4",TRUE
+"203380_x_at",0.725836505745628,0.204912260249257,-1.30611159172136,-5.14128378538571,-0.450041168310136,"SRSF5","serine and arginine rich splicing factor 5",TRUE
+"212266_s_at",0.746682325968302,0.238542298814601,-1.21129885141792,-5.24924471919221,-0.389090292245859,"SRSF5","serine and arginine rich splicing factor 5",TRUE
+"210077_s_at",0.912906062613339,0.634734777690829,-0.481711408881455,-5.82729012649417,-0.214636087675279,"SRSF5","serine and arginine rich splicing factor 5",TRUE
+"208804_s_at",0.597654932724127,0.0742872605178555,-1.87324330926621,-4.36138453402763,-0.589137542724501,"SRSF6","serine and arginine rich splicing factor 6",TRUE
+"206108_s_at",0.837609393049242,0.421723169758994,-0.818615969818772,-5.61845372948203,-0.792279630691588,"SRSF6","serine and arginine rich splicing factor 6",TRUE
+"213649_at",0.327864702134751,0.00767258119444435,2.93240079188899,-2.44407599388918,1.04869902666915,"SRSF7","serine and arginine rich splicing factor 7",TRUE
+"211439_at",0.748438284778152,0.241040745624106,1.20467138162974,-5.2565289837469,0.355226132463987,"SRSF7","serine and arginine rich splicing factor 7",TRUE
+"201129_at",0.897710071620737,0.585334560206129,-0.553692021703637,-5.79145529021508,-0.190034507386066,"SRSF7","serine and arginine rich splicing factor 7",TRUE
+"214141_x_at",0.979998976135556,0.904679597310549,-0.121130355856351,-5.93253954211413,-0.0300663914614567,"SRSF7","serine and arginine rich splicing factor 7",TRUE
+"213152_s_at",0.812302873476553,0.358789931004544,0.937140178581807,-5.52074927093714,0.401984672883057,"SRSF8","serine and arginine rich splicing factor 8",TRUE
+"228760_at",0.913930616146701,0.638756847458873,0.475967898393451,-5.82993988457853,0.253828957783641,"SRSF8","serine and arginine rich splicing factor 8",TRUE
+"214789_x_at",0.933649615158206,0.70643165851815,0.381547348090271,-5.86902529522075,0.138201246206384,"SRSF8","serine and arginine rich splicing factor 8",TRUE
+"238929_at",0.952914447461733,0.78424817127413,0.27713160158733,-5.90234517171778,0.119855257726543,"SRSF8","serine and arginine rich splicing factor 8",TRUE
+"225252_at",0.942684843065067,0.743055705113292,0.331937899209878,-5.88615954595839,0.149489131571462,"SRXN1","sulfiredoxin 1",TRUE
+"207893_at",0.999488289991365,0.998389378368908,0.00204151395667256,-5.93968145077771,0.00105222677245331,"SRY","sex determining region Y",TRUE
+"202817_s_at",0.897449856549225,0.584107287359542,-0.555516864849072,-5.79048382513214,-0.23898678905919,"SS18","SS18, nBAF chromatin remodeling complex subunit",TRUE
+"216684_s_at",0.904832003218088,0.609850979128575,0.517623205640387,-5.81001870657057,0.202416860222591,"SS18","SS18, nBAF chromatin remodeling complex subunit",TRUE
+"202816_s_at",0.943512938262733,0.747326264935188,0.326210464784056,-5.88798599442278,0.121902880781327,"SS18","SS18, nBAF chromatin remodeling complex subunit",TRUE
+"209954_x_at",0.988713664405312,0.945611168943093,0.0689966848385467,-5.93736506198412,0.0217288505528757,"SS18","SS18, nBAF chromatin remodeling complex subunit",TRUE
+"213140_s_at",0.622966572974459,0.093920685158271,-1.75020339530368,-4.54860402173587,-0.630840841420129,"SS18L1","SS18L1, nBAF chromatin remodeling complex subunit",TRUE
+"218283_at",0.956398858120188,0.802243219707164,-0.253468620906495,-5.90843981225457,-0.0700703141776753,"SS18L2","SS18 like 2",TRUE
+"201139_s_at",0.851733415458562,0.456265009244785,-0.758295211247579,-5.66343140320228,-0.241576967152646,"SSB","Sjogren syndrome antigen B",TRUE
+"201138_s_at",0.958794064221941,0.813596099121362,0.238616502723263,-5.911989148711,0.0709132340319574,"SSB","Sjogren syndrome antigen B",TRUE
+"202591_s_at",0.820611742812032,0.381100921562778,-0.893674379276085,-5.55799973591394,-0.220074850133186,"SSBP1","single stranded DNA binding protein 1",TRUE
+"214060_at",0.882563842573144,0.540272735453555,0.622027091147405,-5.75296709550015,0.196628813851496,"SSBP1","single stranded DNA binding protein 1",TRUE
+"1562442_a_at",0.953564723226096,0.786121790336666,-0.274660530401289,-5.90300686266174,-0.148104897264123,"SSBP1","single stranded DNA binding protein 1",TRUE
+"238484_s_at",0.0784999806891434,0.000259786298546176,-4.33928604813546,0.532170531242842,-2.82437980881807,"SSBP2","single stranded DNA binding protein 2",TRUE
+"210829_s_at",0.304824368772306,0.0060227374192806,-3.03680788598543,-2.23333762302978,-2.05370013133257,"SSBP2","single stranded DNA binding protein 2",TRUE
+"203787_at",0.361092857488395,0.0103952475114172,-2.79986865061593,-2.70736096069797,-1.7046370818548,"SSBP2","single stranded DNA binding protein 2",TRUE
+"1558604_a_at",0.62213351293663,0.0923158516772726,-1.75938123451243,-4.53495867393151,-1.218240881468,"SSBP2","single stranded DNA binding protein 2",TRUE
+"238483_at",0.807544796225587,0.348908549706377,-0.956969904697363,-5.50321536333103,-0.547924422810141,"SSBP2","single stranded DNA binding protein 2",TRUE
+"238861_at",0.955730092376044,0.79758963076522,-0.259573244417081,-5.90691919034177,-0.179159881015356,"SSBP2","single stranded DNA binding protein 2",TRUE
+"217991_x_at",0.358391501004667,0.00971029690133248,-2.82977937735455,-2.64838229886696,-1.03109344038003,"SSBP3","single stranded DNA binding protein 3",TRUE
+"222482_at",0.358427723880268,0.0099749919451186,-2.81798958952805,-2.67166150281035,-1.22248315656347,"SSBP3","single stranded DNA binding protein 3",TRUE
+"223635_s_at",0.468735421183467,0.0249591263656969,-2.40499204926189,-3.45770430699627,-1.06711845576249,"SSBP3","single stranded DNA binding protein 3",TRUE
+"232469_x_at",0.527546822913581,0.040170425526836,-2.17987151548324,-3.85745437118857,-0.844137908770032,"SSBP3-AS1","SSBP3 antisense RNA 1",TRUE
+"229270_x_at",0.425751189365875,0.0181636268422617,-2.5507875713129,-3.18727794375974,-1.70661330726931,"SSBP4","single stranded DNA binding protein 4",TRUE
+"229269_x_at",0.784552021081681,0.307980092996094,-1.04347551211598,-5.422823748794,-0.417245217411317,"SSBP4","single stranded DNA binding protein 4",TRUE
+"223226_x_at",0.975906269688816,0.884732438402662,0.14665257574669,-5.9292136506196,0.0470239698325674,"SSBP4","single stranded DNA binding protein 4",TRUE
+"236529_at",0.843121215318579,0.437522678379574,-0.790662462690838,-5.63969981636741,-0.230807551138546,"SSC4D","scavenger receptor cysteine rich family member with 4 domains",TRUE
+"230228_at",0.959650680479973,0.818024318508452,0.232838425459739,-5.91331241364721,0.095691648798633,"SSC5D","scavenger receptor cysteine rich family member with 5 domains",TRUE
+"202506_at",0.48580305784244,0.0283146410792508,2.34618194709419,-3.56432353099158,1.15277676401176,"SSFA2","sperm specific antigen 2",TRUE
+"236207_at",0.59741849655321,0.0735005154025744,1.8787396364241,-4.35280953002979,1.30822519959003,"SSFA2","sperm specific antigen 2",TRUE
+"229744_at",0.62110896023334,0.0916398104628691,1.76328845275124,-4.52913358915231,1.04154079314793,"SSFA2","sperm specific antigen 2",TRUE
+"221753_at",0.705559553212919,0.177420550790679,1.39306511694995,-5.03624668975479,0.414334317368878,"SSH1","slingshot protein phosphatase 1",TRUE
+"1554274_a_at",0.820293495506061,0.379210943830009,-0.897290027166124,-5.55496338677,-0.461944300424485,"SSH1","slingshot protein phosphatase 1",TRUE
+"221752_at",0.837368340567858,0.42061761146662,0.82059625560949,-5.61692234834214,0.354299230630506,"SSH1","slingshot protein phosphatase 1",TRUE
+"1555624_a_at",0.970957388308028,0.861127844163567,0.176985278781931,-5.9244383242705,0.0717759235605344,"SSH1","slingshot protein phosphatase 1",TRUE
+"1555423_at",0.506075588181688,0.0331459841111774,2.27189055369712,-3.69684348943339,1.12051748319703,"SSH2","slingshot protein phosphatase 2",TRUE
+"226080_at",0.734861913384601,0.219837060513422,1.26266598872004,-5.19161880953855,0.387779898025551,"SSH2","slingshot protein phosphatase 2",TRUE
+"1554114_s_at",0.79943091106207,0.334229289900993,0.987145627830938,-5.47588990934278,0.522976657378901,"SSH2","slingshot protein phosphatase 2",TRUE
+"1555425_x_at",0.937856707467078,0.7251159101386,0.356124508382431,-5.87809994164754,0.210700148191695,"SSH2","slingshot protein phosphatase 2",TRUE
+"1560306_at",0.974884920935236,0.877393535045843,0.156066873779261,-5.92782710637434,0.133428651386316,"SSH2","slingshot protein phosphatase 2",TRUE
+"51192_at",0.916042382946954,0.645690750375937,0.466104167933969,-5.83441791859747,0.351796347320944,"SSH3","slingshot protein phosphatase 3",TRUE
+"219241_x_at",0.937113154905832,0.720429159127486,0.362478467431261,-5.8758897827517,0.233652321120742,"SSH3","slingshot protein phosphatase 3",TRUE
+"219919_s_at",0.951934441578502,0.780198385211939,0.282478817466059,-5.90089318548082,0.200451521254099,"SSH3","slingshot protein phosphatase 3",TRUE
+"1553330_at",0.739340500562926,0.226896306826519,-1.24290310721602,-5.21403350046988,-1.0102115763799,"SSMEM1","serine rich single-pass membrane protein 1",TRUE
+"1553329_at",0.998870448604467,0.996138413129565,-0.00489470060195458,-5.93967181165159,-0.00245447971675627,"SSMEM1","serine rich single-pass membrane protein 1",TRUE
+"210378_s_at",0.773107052530371,0.28378254974331,-1.09849466609195,-5.36844191497321,-0.343633012416127,"SSNA1","SS nuclear autoantigen 1",TRUE
+"204964_s_at",0.157590489552653,0.00122498322926159,3.7045964423454,-0.835486451417127,3.46164704337969,"SSPN","sarcospan",TRUE
+"226932_at",0.296090407530139,0.00534112972544138,3.08823641174714,-2.12855683997463,3.06833106222935,"SSPN","sarcospan",TRUE
+"204963_at",0.323645710780045,0.00737124516016447,2.94975081563662,-2.4092491935488,3.04551443144244,"SSPN","sarcospan",TRUE
+"1561517_at",0.593337376134677,0.0699658167360308,1.90408692637147,-4.31303652131713,1.38959282384272,"SSPN","sarcospan",TRUE
+"234349_at",0.975475861996229,0.88319707449792,-0.14862097943106,-5.92893085810563,-0.0608284943118269,"SSPO","SCO-spondin",TRUE
+"226712_at",0.722192678020526,0.198535921061914,1.32542380864446,-5.11844610129416,0.407581848877399,"SSR1","signal sequence receptor subunit 1",TRUE
+"200889_s_at",0.726696341943087,0.206568842603039,1.30117089732683,-5.14708085178202,0.506763172592313,"SSR1","signal sequence receptor subunit 1",TRUE
+"201894_s_at",0.739340500562926,0.226834334922487,1.24307454530025,-5.2138403647902,0.454756675266207,"SSR1","signal sequence receptor subunit 1",TRUE
+"200890_s_at",0.774360462422895,0.290565898811399,1.08274223206977,-5.38426690623301,0.437806482625286,"SSR1","signal sequence receptor subunit 1",TRUE
+"225435_at",0.895213601869362,0.57343173871352,0.571472059256967,-5.78185794449218,0.212256430475733,"SSR1","signal sequence receptor subunit 1",TRUE
+"200891_s_at",0.896159990898752,0.579129079063525,0.562938689100393,-5.78650081827765,0.176957219525841,"SSR1","signal sequence receptor subunit 1",TRUE
+"200652_at",0.713330901550199,0.188139979364865,-1.3579774339014,-5.07931245614907,-0.475177807163364,"SSR2","signal sequence receptor subunit 2",TRUE
+"237817_at",0.552420073963858,0.0495727918855469,2.07725542467792,-4.03167012038279,0.736461063841719,"SSR3","signal sequence receptor subunit 3",TRUE
+"222411_s_at",0.690937549779432,0.160640765591859,1.45154682506631,-4.96245910825794,0.429293395903327,"SSR3","signal sequence receptor subunit 3",TRUE
+"217790_s_at",0.693742297578797,0.162933669985896,1.4432741973776,-4.9730475576329,0.659926589649329,"SSR3","signal sequence receptor subunit 3",TRUE
+"222412_s_at",0.735413789306046,0.220467720998844,1.26088081622198,-5.19365597309189,0.454156664141756,"SSR3","signal sequence receptor subunit 3",TRUE
+"201004_at",0.40221114169538,0.0145938991389195,-2.64940570846223,-2.99979020646001,-0.821455951443415,"SSR4","signal sequence receptor subunit 4",TRUE
+"223768_at",0.968066640321622,0.850090130313965,-0.191225863009954,-5.92188856057741,-0.0661446016305778,"SSR4P1","signal sequence receptor subunit 4 pseudogene 1",TRUE
+"200957_s_at",0.774230543658252,0.287154134202931,1.09063154955883,-5.37636670195981,0.450967308518344,"SSRP1","structure specific recognition protein 1",TRUE
+"200956_s_at",0.822850703882235,0.38859001900201,0.879461602802156,-5.56982525963601,0.340651381799354,"SSRP1","structure specific recognition protein 1",TRUE
+"203114_at",0.899808883319249,0.593551493440461,-0.5415226167018,-5.79785434089401,-0.215173916435461,"SSSCA1","Sjogren syndrome/scleroderma autoantigen 1",TRUE
+"1557131_at",0.896229101808264,0.579837463548273,0.561880642950308,-5.78707176500862,0.306461875653643,"SSSCA1-AS1","SSSCA1 antisense RNA 1 (head to head)",TRUE
+"213921_at",0.91679324405498,0.648371892456572,0.462302746126403,-5.836119212906,0.313441004267527,"SST","somatostatin",TRUE
+"235591_at",0.432151440378733,0.0193485114191076,-2.52205139672636,-3.24123753120436,-2.59296363930994,"SSTR1","somatostatin receptor 1",TRUE
+"208482_at",0.973071267819624,0.87050982214947,0.16491038435843,-5.92644626131061,0.0816653708188313,"SSTR1","somatostatin receptor 1",TRUE
+"217455_s_at",0.81836001261482,0.37152064932652,-0.912125759425601,-5.54238604453133,-0.987402570849471,"SSTR2","somatostatin receptor 2",TRUE
+"239031_at",0.94895689004559,0.768394159125582,-0.298113505591029,-5.89648983132663,-0.104407683441989,"SSTR2","somatostatin receptor 2",TRUE
+"214597_at",0.982909728377256,0.917127167554368,-0.105246551670641,-5.93428980174748,-0.0734960066927659,"SSTR2","somatostatin receptor 2",TRUE
+"1553178_a_at",0.739340500562926,0.226627462012,1.24364709383161,-5.21319518717414,0.405575095324031,"SSTR3","somatostatin receptor 3",TRUE
+"214491_at",0.866000645572812,0.496569717335867,-0.691279443619441,-5.70957431949189,-0.353904112079547,"SSTR3","somatostatin receptor 3",TRUE
+"214556_at",0.778955753047799,0.299945308310455,1.06139069501938,-5.40539075727342,0.433845305913547,"SSTR4","somatostatin receptor 4",TRUE
+"214555_at",0.952697366942815,0.783611149891304,0.277972154655314,-5.902118751793,0.235519440309138,"SSTR5","somatostatin receptor 5",TRUE
+"1557146_a_at",0.911609391328214,0.629931676520736,0.488591850646437,-5.8240749388877,0.161599718170987,"SSTR5-AS1","SSTR5 antisense RNA 1",TRUE
+"226229_s_at",0.858994261239434,0.475409801185465,-0.726047782803954,-5.68614113621584,-0.375019577528814,"SSU72","SSU72 homolog, RNA polymerase II CTD phosphatase",TRUE
+"223051_at",0.895657764833717,0.575130342093976,-0.5689234636637,-5.78325168668202,-0.137077610832772,"SSU72","SSU72 homolog, RNA polymerase II CTD phosphatase",TRUE
+"223053_x_at",0.922389916958654,0.668439566341761,-0.434063811773672,-5.84832956650211,-0.117102168344816,"SSU72","SSU72 homolog, RNA polymerase II CTD phosphatase",TRUE
+"223052_x_at",0.939899468413492,0.729812382844561,-0.349772321766388,-5.88027088638014,-0.105414102092513,"SSU72","SSU72 homolog, RNA polymerase II CTD phosphatase",TRUE
+"206741_at",0.878357372763681,0.531335925867142,-0.635930929423023,-5.74460774325583,-0.262088415195968,"SSUH2","ssu-2 homolog (C. elegans)",TRUE
+"206626_x_at",0.859781203630624,0.478002885048965,0.721739380531378,-5.68910430998884,0.449761015420017,"SSX1","SSX family member 1",TRUE
+"206627_s_at",0.941595310742151,0.738517269511763,-0.338037035316271,-5.88417998658062,-0.371732151352995,"SSX1","SSX family member 1",TRUE
+"215885_at",0.912041701968169,0.631467738686895,0.486388855243108,-5.82510923571313,0.382606625873498,"SSX2B","SSX family member 2B",TRUE
+"216471_x_at",0.918041148686074,0.651893798794699,0.457319734367638,-5.8383286449639,0.303210311563602,"SSX2B///SSX2","SSX family member 2B///SSX family member 2",TRUE
+"207493_x_at",0.970526265934304,0.859389483291893,-0.179225508324193,-5.92405024428195,-0.111359647731689,"SSX2B///SSX2","SSX family member 2B///SSX family member 2",TRUE
+"210497_x_at",0.990810941805126,0.956100035948229,-0.0556745995074651,-5.93817386291095,-0.0466996622570841,"SSX2B///SSX2","SSX family member 2B///SSX family member 2",TRUE
+"215881_x_at",0.849935057946582,0.452091180349217,-0.765432385998595,-5.65827892966154,-0.20638605003352,"SSX2B///SSX3///SSX2","SSX family member 2B///SSX family member 3///SSX family member 2",TRUE
+"203015_s_at",0.728622545366091,0.210076400036112,1.29081030217282,-5.15917671724622,0.418200311309725,"SSX2IP","SSX family member 2 interacting protein",TRUE
+"210871_x_at",0.821699646436315,0.384331505410441,0.887521201972405,-5.5631409559142,0.263379381164903,"SSX2IP","SSX family member 2 interacting protein",TRUE
+"203017_s_at",0.821962235882611,0.385266140264539,0.885747352852545,-5.56461696552117,0.265041298829702,"SSX2IP","SSX family member 2 interacting protein",TRUE
+"203018_s_at",0.884769004468037,0.544727469283798,0.615142465704349,-5.7570404206682,0.189083363121235,"SSX2IP","SSX family member 2 interacting protein",TRUE
+"203016_s_at",0.902268042923638,0.601040928447875,0.530502297652638,-5.80352986426903,0.171529432454726,"SSX2IP","SSX family member 2 interacting protein",TRUE
+"203019_x_at",0.982243328340126,0.914748367981474,0.108279763235539,-5.93397451858663,0.0316526539402835,"SSX2IP","SSX family member 2 interacting protein",TRUE
+"211670_x_at",0.759576632581869,0.257182569442613,-1.16305021548335,-5.30147823917411,-0.884796955328231,"SSX3","SSX family member 3",TRUE
+"211731_x_at",0.838287089408256,0.422992112949181,0.816347033973274,-5.62020406447469,0.234380864914231,"SSX3","SSX family member 3",TRUE
+"207666_x_at",0.911393258378799,0.629502997301388,-0.489207092810584,-5.82378526940405,-0.448950771852597,"SSX3","SSX family member 3",TRUE
+"211425_x_at",0.774011928861764,0.285579314925611,1.09429595064492,-5.37267986595049,1.31927526335411,"SSX4B///SSX4","SSX family member 4B///SSX family member 4",TRUE
+"210394_x_at",0.794426378358553,0.326330177425252,1.0037622046068,-5.46051340060751,0.673958581980176,"SSX4B///SSX4","SSX family member 4B///SSX family member 4",TRUE
+"208586_s_at",0.934081042629428,0.708119570466542,0.379240384009651,-5.86987422132208,0.387600104127724,"SSX4B///SSX4","SSX family member 4B///SSX family member 4",TRUE
+"208528_x_at",0.945432830098469,0.753327998592152,-0.318180000215021,-5.8904938727453,-0.173615178735551,"SSX7///SSX3///SSX5","SSX family member 7///SSX family member 3///SSX family member 5",TRUE
+"208667_s_at",0.761748280722165,0.261023307208883,1.15343480951971,-5.31166577803909,0.414066149304558,"ST13","suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)",TRUE
+"207040_s_at",0.771623843789204,0.280968760078697,1.10510881993734,-5.36173669122546,0.34494007257414,"ST13","suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)",TRUE
+"208666_s_at",0.879161148925378,0.532994906049397,0.633340421403918,-5.74617870277523,0.235195218555946,"ST13","suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)",TRUE
+"202005_at",0.71242055183987,0.18657635759547,1.36299539011474,-5.07320958161446,1.28787300645915,"ST14","suppression of tumorigenicity 14",TRUE
+"216905_s_at",0.728825906537591,0.210344062630968,1.29002519765915,-5.16008996887845,1.45454881933966,"ST14","suppression of tumorigenicity 14",TRUE
+"216906_at",0.913627134030439,0.637767120878458,-0.477379713236749,-5.82929142816034,-0.263094587316722,"ST14","suppression of tumorigenicity 14",TRUE
+"1570306_at",0.800783587314898,0.336687939738361,-0.982028996981164,-5.48057768657051,-0.559504183852652,"ST18","ST18, C2H2C-type zinc finger",TRUE
+"206135_at",0.873301865850313,0.518373822922683,-0.656324955840373,-5.73202509132468,-0.365583627302835,"ST18","ST18, C2H2C-type zinc finger",TRUE
+"1557583_at",0.908033019585207,0.618541962166099,0.505004470801426,-5.81622561411964,0.424330091330563,"ST18","ST18, C2H2C-type zinc finger",TRUE
+"1570307_s_at",0.989669132517581,0.950464268680689,-0.0628312408839332,-5.93776085296494,-0.0191814220097091,"ST18","ST18, C2H2C-type zinc finger",TRUE
+"210242_x_at",0.782096995485383,0.303814007459832,-1.0527226630369,-5.4138587626124,-0.355383398902363,"ST20","suppressor of tumorigenicity 20",TRUE
+"217104_at",0.908224453443807,0.618805255412688,-0.504623490190026,-5.81641068740306,-0.233268035544885,"ST20","suppressor of tumorigenicity 20",TRUE
+"1556588_at",0.335661229817476,0.00829015945652374,-2.89879168074012,-2.51131048211226,-1.12005609734132,"ST20-AS1","ST20 antisense RNA 1",TRUE
+"203433_at",0.768852835478002,0.272031180152561,-1.12644236556576,-5.33986627988026,-0.391404297501614,"ST20-MTHFS///MTHFS","ST20-MTHFS readthrough///5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)",TRUE
+"1559069_at",0.99872918752906,0.994637457524369,0.00679724229125317,-5.93966097723852,0.00405051994648442,"ST20-MTHFS///MTHFS","ST20-MTHFS readthrough///5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)",TRUE
+"225033_at",0.821424121108148,0.382804943991094,-0.890424549421137,-5.56071919439355,-0.690174087394762,"ST3GAL1","ST3 beta-galactoside alpha-2,3-sialyltransferase 1",TRUE
+"225034_at",0.860129258554157,0.479595803864326,-0.719099521955644,-5.69091163000949,-0.58890797009572,"ST3GAL1","ST3 beta-galactoside alpha-2,3-sialyltransferase 1",TRUE
+"208322_s_at",0.901781358899845,0.598992926334907,-0.533509171889631,-5.80199256818858,-0.333244095565793,"ST3GAL1","ST3 beta-galactoside alpha-2,3-sialyltransferase 1",TRUE
+"228784_at",0.410263142293979,0.015896356343638,2.61103582703999,-3.07315150764703,1.35341870405356,"ST3GAL2","ST3 beta-galactoside alpha-2,3-sialyltransferase 2",TRUE
+"238896_at",0.61760967235709,0.0880786539725988,-1.78428883988435,-4.49766293180511,-0.462883120241209,"ST3GAL2","ST3 beta-galactoside alpha-2,3-sialyltransferase 2",TRUE
+"205346_at",0.697172073261335,0.167612944511712,-1.42667850630268,-4.99413996150935,-1.20250818299492,"ST3GAL2","ST3 beta-galactoside alpha-2,3-sialyltransferase 2",TRUE
+"229336_at",0.892824991541776,0.566213447587164,0.582345479695242,-5.77584385562652,0.243374022302498,"ST3GAL2","ST3 beta-galactoside alpha-2,3-sialyltransferase 2",TRUE
+"217650_x_at",0.959593724813212,0.8176140306682,-0.23337343808913,-5.9131912432659,-0.136487171301272,"ST3GAL2","ST3 beta-galactoside alpha-2,3-sialyltransferase 2",TRUE
+"1555181_a_at",0.657015752622694,0.125658315640057,1.59152914303208,-4.77596831617602,0.440687491752998,"ST3GAL3","ST3 beta-galactoside alpha-2,3-sialyltransferase 3",TRUE
+"225905_s_at",0.774880457498598,0.291372058997964,-1.08088782449976,-5.38611644566824,-0.551958478528552,"ST3GAL3","ST3 beta-galactoside alpha-2,3-sialyltransferase 3",TRUE
+"1555703_at",0.794426378358553,0.326209004853734,-1.00401926249375,-5.46027369678975,-0.643732116848225,"ST3GAL3","ST3 beta-galactoside alpha-2,3-sialyltransferase 3",TRUE
+"1555702_a_at",0.840039213897998,0.428892449125974,0.80585240384475,-5.62824068586998,0.28918988110435,"ST3GAL3","ST3 beta-galactoside alpha-2,3-sialyltransferase 3",TRUE
+"1555171_at",0.900230636329568,0.594974853306667,0.539423029218942,-5.79894438986259,0.570260619556717,"ST3GAL3","ST3 beta-galactoside alpha-2,3-sialyltransferase 3",TRUE
+"231659_at",0.925504446660705,0.677218850962144,-0.421822971295682,-5.85338773578959,-0.159134347369923,"ST3GAL3","ST3 beta-galactoside alpha-2,3-sialyltransferase 3",TRUE
+"1555678_at",0.965815966108792,0.840039577105945,-0.204228051120868,-5.91938891176989,-0.113008376104268,"ST3GAL3","ST3 beta-galactoside alpha-2,3-sialyltransferase 3",TRUE
+"203759_at",0.887189117711068,0.551624312481303,0.6045422879011,-5.76322658167027,0.32994266302625,"ST3GAL4","ST3 beta-galactoside alpha-2,3-sialyltransferase 4",TRUE
+"215710_at",0.954618087644887,0.793135752432824,-0.265425337421668,-5.90542772161026,-0.252405375186829,"ST3GAL4","ST3 beta-galactoside alpha-2,3-sialyltransferase 4",TRUE
+"230999_at",0.756313947022433,0.251521580860931,1.17741886740034,-5.28611659248151,0.674960053698108,"ST3GAL4-AS1","ST3GAL4 antisense RNA 1 (head to head)",TRUE
+"227925_at",0.778146335240385,0.297513551277692,1.06688001966636,-5.39999592031103,0.620064514216568,"ST3GAL4-AS1","ST3GAL4 antisense RNA 1 (head to head)",TRUE
+"203217_s_at",0.77547560202111,0.292604270850432,-1.07806048152079,-5.38893091830887,-0.850919231957931,"ST3GAL5","ST3 beta-galactoside alpha-2,3-sialyltransferase 5",TRUE
+"213355_at",0.627021415091472,0.0976647842238469,1.7293025878207,-4.57948154425516,2.56396350814157,"ST3GAL6","ST3 beta-galactoside alpha-2,3-sialyltransferase 6",TRUE
+"210942_s_at",0.699391325858549,0.170908327017975,1.4152128728009,-5.00859550405001,1.85964353761468,"ST3GAL6","ST3 beta-galactoside alpha-2,3-sialyltransferase 6",TRUE
+"213873_at",0.717523070627119,0.193242381618369,1.34182811315044,-5.09882555761592,0.47381138658333,"ST3GAL6","ST3 beta-galactoside alpha-2,3-sialyltransferase 6",TRUE
+"213335_s_at",0.930827859648584,0.693564188204391,-0.39920461466615,-5.8623596761923,-0.321086430483732,"ST3GAL6","ST3 beta-galactoside alpha-2,3-sialyltransferase 6",TRUE
+"202440_s_at",0.637485146909712,0.108638594110414,1.67175009665685,-4.66306869479269,1.07359720703028,"ST5","suppression of tumorigenicity 5",TRUE
+"214970_s_at",0.80110325033185,0.337737722879773,0.979852148210732,-5.48256535457421,0.706677516077827,"ST6GAL1","ST6 beta-galactoside alpha-2,6-sialyltransferase 1",TRUE
+"201998_at",0.961362864777978,0.824581023534307,0.224297832730353,-5.91520923389876,0.165319625934652,"ST6GAL1","ST6 beta-galactoside alpha-2,6-sialyltransferase 1",TRUE
+"214971_s_at",0.968066640321622,0.849654756187727,0.191788382472597,-5.9217838065743,0.249495523758992,"ST6GAL1","ST6 beta-galactoside alpha-2,6-sialyltransferase 1",TRUE
+"1555123_at",0.57460012602512,0.0605720404260226,-1.97737061904412,-4.19597909131056,-0.782874849381752,"ST6GAL2","ST6 beta-galactoside alpha-2,6-sialyltransferase 2",TRUE
+"228821_at",0.997056683282451,0.985185006998649,0.0187796130681094,-5.93951170777132,0.0167573552031599,"ST6GAL2","ST6 beta-galactoside alpha-2,6-sialyltransferase 2",TRUE
+"227725_at",0.623503825356688,0.0946023422713682,1.74634570527072,-4.55432379611867,1.7160921980049,"ST6GALNAC1","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1",TRUE
+"204542_at",0.916107385524794,0.646253217542407,-0.46530610513713,-5.83477621645923,-0.676641352997263,"ST6GALNAC2","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2",TRUE
+"235334_at",0.971216837324271,0.862647975335676,-0.17502704220042,-5.9247735676668,-0.123303519070039,"ST6GALNAC3","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3",TRUE
+"223285_s_at",0.789795896476304,0.318315021793047,1.02091098032629,-5.44440054581719,1.05939746374776,"ST6GALNAC4","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4",TRUE
+"220937_s_at",0.875723781180194,0.523233013526288,0.648647332984295,-5.73680677387102,0.636579000505954,"ST6GALNAC4","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4",TRUE
+"228163_at",0.904540796040532,0.608482348242922,-0.519618095396258,-5.80902379235567,-0.32110649135764,"ST6GALNAC4","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4",TRUE
+"221551_x_at",0.913300726876965,0.636534546718747,0.479139320471302,-5.82848059832092,0.367644598562237,"ST6GALNAC4","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4",TRUE
+"230482_at",0.725181883744124,0.20383883097364,1.30932964680584,-5.1374979415058,1.30788306242114,"ST6GALNAC5","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5",TRUE
+"220979_s_at",0.769847953580141,0.278402675691895,1.11118274249652,-5.35554766028411,1.31903275930811,"ST6GALNAC5","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5",TRUE
+"1562753_at",0.852094603401457,0.457637495173194,0.755956872214137,-5.6651095696643,0.487787124332162,"ST6GALNAC5","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5",TRUE
+"222571_at",0.887929552412429,0.553350226599885,-0.601900561458123,-5.76475211303689,-0.443683395971501,"ST6GALNAC6","ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6",TRUE
+"1555912_at",0.841420204214686,0.432217317952778,0.79997815697981,-5.63269646336329,0.651994324053792,"ST7-AS1","ST7 antisense RNA 1",TRUE
+"237808_at",0.726636642789909,0.205938271767335,1.30304791219308,-5.14488068587607,1.03210413725802,"ST7-AS2","ST7 antisense RNA 2",TRUE
+"1564790_at",0.830179476576763,0.401963260784941,-0.854518097877393,-5.59015326808404,-0.735787544161561,"ST7-AS2","ST7 antisense RNA 2",TRUE
+"1559208_at",0.864894115958506,0.493715682583035,0.695918497836801,-5.70651105735599,0.74855430195014,"ST7-OT4","ST7 overlapping transcript 4",TRUE
+"1552738_a_at",0.140294357253668,0.000931446761464679,-3.81730306211428,-0.593948671454062,-1.60017598274466,"ST7L","suppression of tumorigenicity 7 like",TRUE
+"1552739_s_at",0.70939075283402,0.182302701462582,-1.37688194926742,-5.05622293642244,-0.506232630824111,"ST7L","suppression of tumorigenicity 7 like",TRUE
+"230079_at",0.789488409459128,0.316292766014452,-1.0252852639262,-5.44025099861198,-0.425112048208788,"ST7L","suppression of tumorigenicity 7 like",TRUE
+"219964_at",0.807944276806637,0.349608895417346,0.955552049914045,-5.50448022667819,0.5562748387908,"ST7L","suppression of tumorigenicity 7 like",TRUE
+"233141_s_at",0.841206569659492,0.431152162892378,-0.801856970670838,-5.63127466322279,-0.53963944041679,"ST7L","suppression of tumorigenicity 7 like",TRUE
+"210073_at",0.66120440880682,0.128908954487307,1.57725327962453,-4.79560816682895,1.99940395659422,"ST8SIA1","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1",TRUE
+"1569788_at",0.740610299769501,0.229933505289114,1.23454440648001,-5.2234222754548,1.07154460395117,"ST8SIA1","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1",TRUE
+"221285_at",0.818852235468236,0.372669909339947,0.909895845947999,-5.54428866695897,0.350407992176603,"ST8SIA2","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2",TRUE
+"239537_at",0.823073978212882,0.388952243384256,0.878778724126191,-5.57038901235674,0.787082607548724,"ST8SIA2","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2",TRUE
+"208064_s_at",0.683019114815084,0.151803680931521,1.48435221635773,-4.91998746555672,0.887988303746458,"ST8SIA3","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3",TRUE
+"208065_at",0.913343399879786,0.636809579274208,0.478746554651057,-5.82866183841423,0.402901488089565,"ST8SIA3","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3",TRUE
+"230262_at",0.926296314826062,0.6798430456578,0.418176861004609,-5.85486689673239,0.166675555361969,"ST8SIA3","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3",TRUE
+"230261_at",0.646767005028134,0.117903502861909,1.62687197542122,-4.72675492957931,2.49331602354622,"ST8SIA4","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4",TRUE
+"242943_at",0.674277005847759,0.140663987721985,1.52799859443564,-4.86229932639632,2.2791342150195,"ST8SIA4","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4",TRUE
+"230836_at",0.710372201621696,0.183221130004604,1.37387609822075,-5.05991197257675,2.10227170676269,"ST8SIA4","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4",TRUE
+"1554460_at",0.734203380012717,0.218571803721324,1.26625935410638,-5.18751073353844,1.08693365528119,"ST8SIA4","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4",TRUE
+"206925_at",0.855075448726859,0.467270048119947,0.739662405138877,-5.67666738936358,0.898850917169709,"ST8SIA4","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4",TRUE
+"236110_at",0.751579819725748,0.244875341492951,1.19459941033843,-5.26753262338669,0.545087230486738,"ST8SIA5","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5",TRUE
+"206258_at",0.774230543658252,0.286775674855135,-1.09151084887352,-5.37548302351888,-0.341613319294618,"ST8SIA5","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5",TRUE
+"217514_at",0.997128956162635,0.985415226492429,-0.0184877498238922,-5.93951700545539,-0.0133226852055452,"ST8SIA5","ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5",TRUE
+"242350_s_at",0.848387656234402,0.44859418640579,0.771442888375971,-5.65390445308326,1.26704972469353,"ST8SIA6-AS1","ST8SIA6 antisense RNA 1",TRUE
+"204150_at",0.71454754703986,0.189789448859319,-1.35271949028576,-5.08568703091271,-0.73534834420199,"STAB1","stabilin 1",TRUE
+"1555319_at",0.85069818933195,0.453649058912244,0.762763813779941,-5.66021076785691,0.307124554040799,"STAB1","stabilin 1",TRUE
+"1555320_a_at",0.876862063516282,0.525938757669461,0.644389166156671,-5.73943550253495,0.351260808124704,"STAB1","stabilin 1",TRUE
+"38487_at",0.959357995170594,0.816376993276999,-0.234986948979485,-5.91282413794318,-0.112411442884308,"STAB1","stabilin 1",TRUE
+"237567_at",0.826134344333512,0.393776303395081,-0.869723353499633,-5.57782625453563,-0.236579246390791,"STAB2","stabilin 2",TRUE
+"220114_s_at",0.932415412515157,0.701953661585998,-0.387677948169749,-5.86674466544427,-0.255373949575715,"STAB2","stabilin 2",TRUE
+"205743_at",0.180423581063291,0.00165656401817598,3.57989655490276,-1.10139551990887,2.67112427181366,"STAC","SH3 and cysteine rich domain",TRUE
+"228888_at",0.890444623541856,0.559062146750591,-0.593188332341348,-5.76973746974642,-0.274459919694182,"STAC2","SH3 and cysteine rich domain 2",TRUE
+"230852_at",0.994079042628104,0.972442937265005,-0.0349368513686372,-5.93908899697468,-0.0125279848779938,"STAC3","SH3 and cysteine rich domain 3",TRUE
+"202293_at",0.748184017928985,0.240552523946666,1.20596237454103,-5.25511277058295,0.519581210678883,"STAG1","stromal antigen 1",TRUE
+"202294_at",0.87825462101175,0.530440108043381,0.637331576853967,-5.74375578136319,0.259685857638381,"STAG1","stromal antigen 1",TRUE
+"232588_at",0.897630096356516,0.584678566466293,0.554667187901272,-5.79093654126195,0.373885851373561,"STAG1","stromal antigen 1",TRUE
+"209022_at",0.755685495730197,0.249899317315636,-1.18158082675876,-5.28163621252391,-0.311476152456196,"STAG2","stromal antigen 2",TRUE
+"209023_s_at",0.861659105448003,0.482692058649559,-0.713982846176113,-5.69439670466141,-0.258183134295138,"STAG2","stromal antigen 2",TRUE
+"207983_s_at",0.932918358096654,0.703938084698835,-0.384959322009059,-5.86776043733144,-0.119584698302969,"STAG2","stromal antigen 2",TRUE
+"219753_at",0.939356991756184,0.728407348195655,-0.35167114382787,-5.87962598390051,-0.155631257503348,"STAG3","stromal antigen 3",TRUE
+"223724_s_at",0.962966981693287,0.831958644891835,0.214708258132319,-5.9172549583124,0.0743979287268637,"STAG3L2///STAG3L3///STAG3L1","stromal antigen 3-like 2 (pseudogene)///stromal antigen 3-like 3 (pseudogene)///stromal antigen 3-like 1 (pseudogene)",TRUE
+"235263_at",0.971080650532562,0.861335660324227,0.176717527884428,-5.92448438177824,0.0620290308640641,"STAG3L2///STAG3L3///STAG3L1","stromal antigen 3-like 2 (pseudogene)///stromal antigen 3-like 3 (pseudogene)///stromal antigen 3-like 1 (pseudogene)",TRUE
+"1554250_s_at",0.971352228387114,0.863895527981732,-0.173420465454524,-5.92504583096645,-0.113410808985368,"STAG3L2///STAG3L3///TRIM73","stromal antigen 3-like 2 (pseudogene)///stromal antigen 3-like 3 (pseudogene)///tripartite motif containing 73",TRUE
+"221191_at",0.647592740000498,0.118787518783082,1.62274652905254,-4.73254252781518,1.03882913739775,"STAG3L3","stromal antigen 3-like 3 (pseudogene)",TRUE
+"218994_s_at",0.985868869736215,0.931455256954721,-0.0869971156259202,-5.93599781658224,-0.0409939856551729,"STAG3L4","stromal antigen 3-like 4 (pseudogene)",TRUE
+"222801_s_at",0.993083193605528,0.967031589270121,0.0418011941240995,-5.93883245177776,0.0193621720019674,"STAG3L4","stromal antigen 3-like 4 (pseudogene)",TRUE
+"203544_s_at",0.931370027472813,0.695933277945993,0.395944105623167,-5.86361287883654,0.145088526776869,"STAM","signal transducing adaptor molecule",TRUE
+"240101_at",0.993223654424259,0.967722553349669,-0.040924592515881,-5.93886776949363,-0.0364261538729398,"STAM-AS1","STAM antisense RNA 1 (head to head)",TRUE
+"209649_at",0.369623435296638,0.0110710419669761,-2.77213949335569,-2.76179644683345,-0.848891173538846,"STAM2","signal transducing adaptor molecule 2",TRUE
+"228254_at",0.853426537718112,0.46173224347946,-0.749005418588734,-5.6700694789283,-0.235260226057969,"STAM2","signal transducing adaptor molecule 2",TRUE
+"215044_s_at",0.870132281628684,0.508392788964395,-0.672221215419269,-5.7219533564616,-0.219948985674002,"STAM2","signal transducing adaptor molecule 2",TRUE
+"242569_at",0.904832003218088,0.61013122011706,-0.517214994329596,-5.81022183476332,-0.16650479372595,"STAM2","signal transducing adaptor molecule 2",TRUE
+"208194_s_at",0.919156359329732,0.655718947970236,-0.45192095768368,-5.84069593708535,-0.153996374454266,"STAM2","signal transducing adaptor molecule 2",TRUE
+"227515_at",0.615724466562225,0.0861957945508418,1.79568938076068,-4.48046454419376,0.644455416489238,"STAMBP","STAM binding protein",TRUE
+"235361_at",0.85334340854827,0.461099395758586,0.750077357617925,-5.66930747241083,0.28697444521252,"STAMBP","STAM binding protein",TRUE
+"202811_at",0.990496781134316,0.952000106970431,-0.0608806223998356,-5.93787836675525,-0.0144007089538043,"STAMBP","STAM binding protein",TRUE
+"227606_s_at",0.420127229072219,0.0174094361613991,2.57000577866282,-3.1510179215132,1.73264712865684,"STAMBPL1","STAM binding protein like 1",TRUE
+"227607_at",0.556381379241158,0.0517407230774191,2.0561017721586,-4.06691244625694,2.39439063454916,"STAMBPL1","STAM binding protein like 1",TRUE
+"231891_at",0.676294804179428,0.142856589980894,1.51918953361201,-4.87404998370426,1.06023497178967,"STAMBPL1","STAM binding protein like 1",TRUE
+"220803_at",0.937757781799543,0.724574833014444,0.356857294300135,-5.87784701899646,0.339326316703874,"STAMBPL1","STAM binding protein like 1",TRUE
+"1554343_a_at",0.595019326272843,0.0719241345151401,1.88990900484917,-4.3353294320032,1.38151209367737,"STAP1","signal transducing adaptor family member 1",TRUE
+"220059_at",0.795095521135647,0.327214345149944,1.00188851712124,-5.46225891302416,0.874113215763596,"STAP1","signal transducing adaptor family member 1",TRUE
+"221610_s_at",0.865485732379764,0.495309530245319,0.693325916520841,-5.7082254024929,0.392505512920513,"STAP2","signal transducing adaptor family member 2",TRUE
+"204548_at",0.98539961718117,0.928696123616579,-0.0905088268855733,-5.93569432124177,-0.0604132372433797,"STAR","steroidogenic acute regulatory protein",TRUE
+"232322_x_at",0.61760967235709,0.0880401315544058,-1.78451997517463,-4.49731504317786,-1.89955213261178,"STARD10","StAR related lipid transfer domain containing 10",TRUE
+"223103_at",0.697589104334815,0.168116897558134,-1.42491346119226,-4.99637151019978,-1.55061798133918,"STARD10","StAR related lipid transfer domain containing 10",TRUE
+"238911_at",0.729083413548563,0.210979719836535,-1.28816378711305,-5.16225331654906,-0.981354085712561,"STARD10","StAR related lipid transfer domain containing 10",TRUE
+"213103_at",0.512782258764821,0.034316786187846,2.25538814586181,-3.72594043267791,1.12835300410003,"STARD13","StAR related lipid transfer domain containing 13",TRUE
+"242686_at",0.948416315023872,0.764769611280704,0.302929294406697,-5.8950861416909,0.154401267216468,"STARD13","StAR related lipid transfer domain containing 13",TRUE
+"233194_at",0.51356204611816,0.0345194794799623,2.252583529283,-3.73087296958765,1.06690275070968,"STARD13-AS","STARD13 antisense RNA",TRUE
+"233159_at",0.932269331146744,0.701329264215391,0.388533976612207,-5.86642336539472,0.276765783984596,"STARD13-AS","STARD13 antisense RNA",TRUE
+"202991_at",0.832577911481488,0.408804510500815,-0.841963840735066,-5.60017836708011,-0.820308629543746,"STARD3","StAR related lipid transfer domain containing 3",TRUE
+"223065_s_at",0.9802233499944,0.907345290228012,-0.117726236457196,-5.93293529923499,-0.0322332525631239,"STARD3NL","STARD3 N-terminal like",TRUE
+"226390_at",0.752913428584105,0.246038160448938,1.19156854834056,-5.27082811037462,1.40542815222298,"STARD4","StAR related lipid transfer domain containing 4",TRUE
+"213820_s_at",0.620912785033482,0.090952392617172,-1.76728688391847,-4.52316268966681,-1.28978541912521,"STARD5","StAR related lipid transfer domain containing 5",TRUE
+"1553084_at",0.713642508588139,0.18881166233383,1.35583197175529,-5.08191604647472,0.973628022733135,"STARD6","StAR related lipid transfer domain containing 6",TRUE
+"200028_s_at",0.986280597793838,0.932722900585793,-0.0853840894722047,-5.93613319863152,-0.0249191023245938,"STARD7","StAR related lipid transfer domain containing 7",TRUE
+"235584_at",0.896428361916712,0.580960998192168,0.56020385435495,-5.78797446576247,0.157789678448909,"STARD7-AS1","STARD7 antisense RNA 1",TRUE
+"206868_at",0.943512938262733,0.747594274611495,-0.325851398211125,-5.88809945081782,-0.182721793783526,"STARD8","StAR related lipid transfer domain containing 8",TRUE
+"227108_at",0.668227498775206,0.134397604846781,1.55381278564157,-4.82755490719667,1.06073372981089,"STARD9","StAR related lipid transfer domain containing 9",TRUE
+"AFFX-HUMISGF3A/M97935_5_at",0.411110107932987,0.0161176679081801,2.60481147837633,-3.08500312283264,1.08195461537745,"STAT1","signal transducer and activator of transcription 1",TRUE
+"200887_s_at",0.601886119917951,0.0769908193641155,1.85473514144009,-4.39012909066847,0.696832819964634,"STAT1","signal transducer and activator of transcription 1",TRUE
+"AFFX-HUMISGF3A/M97935_MB_at",0.603702127972549,0.0780237318858075,1.84781322166236,-4.4008272881063,0.722730603481404,"STAT1","signal transducer and activator of transcription 1",TRUE
+"AFFX-HUMISGF3A/M97935_MA_at",0.611042853196665,0.0834281645928323,1.81284372225986,-4.45443656472289,0.732878837258086,"STAT1","signal transducer and activator of transcription 1",TRUE
+"AFFX-HUMISGF3A/M97935_3_at",0.623667408398064,0.0950613487756288,1.74376144686312,-4.55815024018467,0.634760304689896,"STAT1","signal transducer and activator of transcription 1",TRUE
+"209969_s_at",0.758722841981575,0.255893252346415,1.16630191454148,-5.29801627885559,0.664753494789986,"STAT1","signal transducer and activator of transcription 1",TRUE
+"225636_at",0.808233282592165,0.350218880700323,0.954318699664209,-5.50557909812614,0.287092612178251,"STAT2","signal transducer and activator of transcription 2",TRUE
+"205170_at",0.816800680706682,0.36875878278587,0.917503396167564,-5.53778003240362,0.354666867035392,"STAT2","signal transducer and activator of transcription 2",TRUE
+"217199_s_at",0.93919895813272,0.727944608593589,0.35229679755268,-5.87941273560581,0.296174051315755,"STAT2","signal transducer and activator of transcription 2",TRUE
+"208992_s_at",0.646224068018448,0.117200001117487,1.6301735836185,-4.72211494067712,0.7359083332487,"STAT3","signal transducer and activator of transcription 3",TRUE
+"243213_at",0.658719765887225,0.126900691249934,1.58603713295864,-4.78354024138312,0.484414296386914,"STAT3","signal transducer and activator of transcription 3",TRUE
+"208991_at",0.678611044120554,0.146135040117361,1.50622250587997,-4.89124840294876,0.561875142691328,"STAT3","signal transducer and activator of transcription 3",TRUE
+"225289_at",0.775581183114088,0.292898038755184,1.07738768544063,-5.38959968199081,0.436389747128182,"STAT3","signal transducer and activator of transcription 3",TRUE
+"206118_at",0.847797601020174,0.447281371437386,0.773706637687233,-5.65224850956694,0.395438092424048,"STAT4","signal transducer and activator of transcription 4",TRUE
+"203010_at",0.552420073963858,0.0501044595736668,2.07199213642901,-4.04046076256048,1.30678102085897,"STAT5A","signal transducer and activator of transcription 5A",TRUE
+"1555086_at",0.654623800601032,0.123542263774761,1.60098828497545,-4.76287906135959,0.607149404187787,"STAT5B","signal transducer and activator of transcription 5B",TRUE
+"205026_at",0.774011928861764,0.285835845553688,1.09369804390391,-5.37328218504022,0.469797902747644,"STAT5B","signal transducer and activator of transcription 5B",TRUE
+"212549_at",0.798737990058781,0.333299122201278,0.989088133988008,-5.47410441083028,0.350177980175026,"STAT5B","signal transducer and activator of transcription 5B",TRUE
+"212550_at",0.829030239823335,0.400026933088086,0.858096220159461,-5.58727066629599,0.33339966876439,"STAT5B","signal transducer and activator of transcription 5B",TRUE
+"1555088_x_at",0.839519981963042,0.427209722339574,0.808836162532033,-5.62596569907996,0.609108236170185,"STAT5B","signal transducer and activator of transcription 5B",TRUE
+"201332_s_at",0.865854896594418,0.496143448867821,0.69197134775546,-5.70911868213556,0.690298232701458,"STAT6","signal transducer and activator of transcription 6",TRUE
+"201331_s_at",0.886783047600321,0.550326679982375,0.606531335650558,-5.76207370029495,0.670276552822447,"STAT6","signal transducer and activator of transcription 6",TRUE
+"206835_at",0.522403182336918,0.0381888834894712,2.20424491640327,-3.81530553342806,1.63324872193938,"STATH","statherin",TRUE
+"211505_s_at",0.716280952967285,0.192082511795269,-1.34546943447926,-5.09444284585466,-0.454627652240699,"STAU1","staufen double-stranded RNA binding protein 1",TRUE
+"208948_s_at",0.736330422786726,0.221875513770669,-1.25690993515183,-5.19817852022102,-0.387943452001332,"STAU1","staufen double-stranded RNA binding protein 1",TRUE
+"213037_x_at",0.869380945553245,0.506411419368628,-0.675397513077811,-5.71991321631666,-0.202630457176868,"STAU1","staufen double-stranded RNA binding protein 1",TRUE
+"207320_x_at",0.939676168830753,0.729443757961016,-0.350270369603422,-5.88010206675724,-0.102228346132533,"STAU1","staufen double-stranded RNA binding protein 1",TRUE
+"1554686_at",0.547343369043481,0.0478064559322554,-2.09511240282552,-4.00173839783619,-1.16629639111004,"STAU2","staufen double-stranded RNA binding protein 2",TRUE
+"204226_at",0.587626678796111,0.0665697839097982,-1.92952054973642,-4.27275551747949,-0.905999966367636,"STAU2","staufen double-stranded RNA binding protein 2",TRUE
+"227179_at",0.624374299616567,0.0959361918851473,1.73886541420944,-4.5653881608826,0.615763751253631,"STAU2","staufen double-stranded RNA binding protein 2",TRUE
+"1561391_at",0.769300526035218,0.276666780858354,1.1153147277119,-5.35132017545992,0.348703515622948,"STAU2-AS1","STAU2 antisense RNA 1",TRUE
+"1557575_at",0.758722841981575,0.25568661038744,1.16682420232186,-5.29745942959868,0.876631141887361,"STBD1","starch binding domain 1",TRUE
+"204596_s_at",0.709158363400091,0.181881807147655,-1.37826347144169,-5.05452516805301,-0.765081575087588,"STC1","stanniocalcin 1",TRUE
+"204597_x_at",0.784708646973769,0.308717765042772,-1.04184739917748,-5.42439481694397,-1.26918803603402,"STC1","stanniocalcin 1",TRUE
+"204595_s_at",0.869082033398093,0.505988504150128,-0.676076384318714,-5.71947598277701,-0.528544786567611,"STC1","stanniocalcin 1",TRUE
+"203438_at",0.918141489589102,0.652464004325468,-0.456514080154907,-5.8386836628554,-0.590750836155546,"STC2","stanniocalcin 2",TRUE
+"203439_s_at",0.921312278448293,0.664952449574862,-0.43894451235033,-5.8462731394447,-0.386438720879552,"STC2","stanniocalcin 2",TRUE
+"205542_at",0.26338132901877,0.00396831393830686,3.21452976344976,-1.86878093082217,2.56469306763696,"STEAP1","six transmembrane epithelial antigen of the prostate 1",TRUE
+"217553_at",0.398650588126476,0.0138999449044488,2.67118643632495,-2.95791935010882,1.7702181908997,"STEAP1B","STEAP family member 1B",TRUE
+"225871_at",0.622434989367596,0.0925067481398964,1.75828238430055,-4.53659518391956,2.26917966702175,"STEAP2","STEAP2 metalloreductase",TRUE
+"1554830_a_at",0.90344422113846,0.604135223375646,0.525968617490048,-5.80583176717944,0.362414541267072,"STEAP3","STEAP3 metalloreductase",TRUE
+"218424_s_at",0.989054168712279,0.946901638956923,0.0673569967590611,-5.93747393394945,0.0374956306528986,"STEAP3","STEAP3 metalloreductase",TRUE
+"220187_at",0.934048461921637,0.708006485352685,0.379394878161056,-5.8698175285543,0.559191835459928,"STEAP4","STEAP4 metalloreductase",TRUE
+"225987_at",0.97304633500821,0.869236254552813,0.16654799285478,-5.92618223347183,0.287810334659404,"STEAP4","STEAP4 metalloreductase",TRUE
+"230587_at",0.937113154905832,0.720229442946937,0.362749564409229,-5.87579462596692,0.216389296571775,"STGC3","uncharacterized STGC3",TRUE
+"1555752_at",0.96287357728432,0.831184809049239,0.21571312291942,-5.91704476535568,0.0748687488497266,"STH","saitohin",TRUE
+"205339_at",0.83364851657447,0.411187678004433,0.837621998633452,-5.60361327482767,0.264079540154885,"STIL","SCL/TAL1 interrupting locus",TRUE
+"1557477_at",0.895457620469779,0.574077145450343,0.570503237279708,-5.78238847226376,0.261286494078359,"STIM1","stromal interaction molecule 1",TRUE
+"202764_at",0.926524168456213,0.68049083921115,-0.417277691639819,-5.85522973274362,-0.241958277106127,"STIM1","stromal interaction molecule 1",TRUE
+"225250_at",0.837201352670384,0.41972346367652,0.82220025159571,-5.61567941613986,0.351468781274646,"STIM2","stromal interaction molecule 2",TRUE
+"234140_s_at",0.91269009113888,0.633639162554521,-0.48327879034372,-5.82656161967219,-0.156114898579107,"STIM2","stromal interaction molecule 2",TRUE
+"225246_at",0.989229849292382,0.94745332031175,-0.0666560812171878,-5.93751967479088,-0.0218561238839303,"STIM2","stromal interaction molecule 2",TRUE
+"212009_s_at",0.855405088766616,0.468478440487316,-0.73763243698302,-5.67809054029339,-0.291516689009695,"STIP1","stress induced phosphoprotein 1",TRUE
+"213330_s_at",0.897949253801113,0.586528759281022,-0.551918179035587,-5.79239663045641,-0.213170048484285,"STIP1","stress induced phosphoprotein 1",TRUE
+"203047_at",0.792436690618566,0.324018201110636,1.00867836821557,-5.4559194866578,0.607121700075378,"STK10","serine/threonine kinase 10",TRUE
+"40420_at",0.842348838616739,0.436054962494007,0.793232624745781,-5.63777532848109,0.316815747154555,"STK10","serine/threonine kinase 10",TRUE
+"228394_at",0.915353407558177,0.642948986668671,0.469998764658973,-5.83266077719613,0.201388354773655,"STK10","serine/threonine kinase 10",TRUE
+"204292_x_at",0.597879550155311,0.0753162441176704,-1.86613085611622,-4.3724545916074,-1.21864038657167,"STK11","serine/threonine kinase 11",TRUE
+"231017_at",0.916827094969925,0.648427744588788,0.462223630596999,-5.83615447543275,0.173111473799828,"STK11","serine/threonine kinase 11",TRUE
+"41657_at",0.988404412848227,0.944692292147025,-0.0701643396042523,-5.93728593657139,-0.0204332117282444,"STK11","serine/threonine kinase 11",TRUE
+"225713_at",0.924812035112346,0.674808678109963,-0.425176844004699,-5.85201598570215,-0.172896380549476,"STK11IP","serine/threonine kinase 11 interacting protein",TRUE
+"238572_at",0.620912785033482,0.0905099148907151,-1.76987435405128,-4.51929350356295,-1.16804162698056,"STK16","serine/threonine kinase 16",TRUE
+"209622_at",0.849276510852753,0.450126311883905,-0.768806048761295,-5.65582753807381,-0.257665406950657,"STK16","serine/threonine kinase 16",TRUE
+"202693_s_at",0.76719388846109,0.269145788286642,1.13343886787145,-5.33261318454573,0.628637073066644,"STK17A","serine/threonine kinase 17a",TRUE
+"202694_at",0.90344422113846,0.603916137371721,-0.526289248651507,-5.80566960389137,-0.195243437235455,"STK17A","serine/threonine kinase 17a",TRUE
+"202695_s_at",0.923749415271371,0.672517611258546,0.428369577444298,-5.85070022442391,0.167796569511438,"STK17A","serine/threonine kinase 17a",TRUE
+"243797_at",0.620912785033482,0.0908953036557156,1.76762011356094,-4.5226646260934,1.54760626511726,"STK17B","serine/threonine kinase 17b",TRUE
+"205214_at",0.822173415758858,0.38653212305578,0.883349112750068,-5.56660817527562,0.328518062171019,"STK17B","serine/threonine kinase 17b",TRUE
+"226525_at",0.880814827834223,0.536420507091985,-0.628005070930073,-5.74939477423302,-0.230482360605631,"STK17B","serine/threonine kinase 17b",TRUE
+"217503_at",0.920463550735258,0.661336436461511,0.444017090835864,-5.844111951074,0.154432489223044,"STK17B","serine/threonine kinase 17b",TRUE
+"36019_at",0.866000265112326,0.496501245493403,0.691390561899696,-5.70950117447169,0.180387783617732,"STK19","serine/threonine kinase 19",TRUE
+"243719_at",0.977361191903387,0.891491531966416,-0.137994063233165,-5.93041290243921,-0.0614040954096504,"STK19","serine/threonine kinase 19",TRUE
+"204090_at",0.986956308803504,0.939914550399445,0.0762372628818391,-5.93685300771297,0.0330511633684196,"STK19","serine/threonine kinase 19",TRUE
+"1562426_a_at",0.338943593173052,0.00843097003594606,2.89146440432271,-2.52592764725483,1.82531650170639,"STK24","serine/threonine kinase 24",TRUE
+"208855_s_at",0.582357061923514,0.0642909414864258,1.94723505838056,-4.2444821497969,0.656950990510596,"STK24","serine/threonine kinase 24",TRUE
+"208854_s_at",0.64513208805899,0.115844296085762,1.63658322807263,-4.71308634714593,0.709332247790426,"STK24","serine/threonine kinase 24",TRUE
+"215188_at",0.848364007856994,0.4483547846026,0.771855400109758,-5.65360304002537,0.791330136610173,"STK24","serine/threonine kinase 24",TRUE
+"1562425_at",0.997056683282451,0.985016171694813,-0.0189936569052043,-5.93950776986754,-0.00760951861164427,"STK24","serine/threonine kinase 24",TRUE
+"232839_at",0.857316604145187,0.472633508589743,-0.730675889701077,-5.68293941262562,-0.36629094581343,"STK24-AS1","STK24 antisense RNA 1",TRUE
+"201314_at",0.709732137447484,0.182550764497924,-1.37606890327772,-5.05722143670507,-0.503122802855493,"STK25","serine/threonine kinase 25",TRUE
+"218499_at",0.89748872632674,0.584264230728516,0.555283398096889,-5.79060828550488,0.340616450868445,"STK26","serine/threonine protein kinase 26",TRUE
+"224407_s_at",0.907238630900214,0.616324910242829,0.508215518138141,-5.8146603332608,0.303814528619695,"STK26","serine/threonine protein kinase 26",TRUE
+"204068_at",0.796797734752337,0.329576237245983,0.99690046479737,-5.46689131530854,0.546123288896563,"STK3","serine/threonine kinase 3",TRUE
+"211078_s_at",0.831487912516861,0.405960900539072,0.84716568112673,-5.59604127252527,0.545850238227711,"STK3","serine/threonine kinase 3",TRUE
+"223883_s_at",0.731548533938014,0.21523813581851,1.2758041891869,-5.17655026548634,1.30499100591706,"STK31","serine/threonine kinase 31",TRUE
+"239353_at",0.685154158710982,0.153655596807895,-1.47735150329202,-4.9291153788318,-1.04866910267798,"STK32A","serine/threonine kinase 32A",TRUE
+"229866_at",0.69880142086258,0.170089607843424,1.41804479355814,-5.00503400461798,1.13825962069618,"STK32A","serine/threonine kinase 32A",TRUE
+"1559624_at",0.790817398514927,0.320583754328452,-1.01602664366916,-5.44901498856891,-0.370544405806962,"STK32A","serine/threonine kinase 32A",TRUE
+"1553938_a_at",0.975242094553739,0.879709739896309,0.153094142428467,-5.92827422798907,0.118573349405774,"STK32A","serine/threonine kinase 32A",TRUE
+"219686_at",0.648323565874229,0.11948009639994,-1.61953239970203,-4.7370437786558,-2.1866926243249,"STK32B","serine/threonine kinase 32B",TRUE
+"227634_at",0.933609099853387,0.706080839283181,-0.382027096792847,-5.86884811767586,-0.233907186563014,"STK32C","serine/threonine kinase 32C",TRUE
+"228086_at",0.769847953580141,0.277854512397907,1.11248551577207,-5.35421627850508,0.713332791217026,"STK33","serine/threonine kinase 33",TRUE
+"228035_at",0.931370027472813,0.696079211053942,0.395743405267241,-5.86368968889082,0.212619699172338,"STK33","serine/threonine kinase 33",TRUE
+"225648_at",0.902024395176837,0.600420532140565,-0.531412638993938,-5.80306533505501,-0.198056895763431,"STK35","serine/threonine kinase 35",TRUE
+"225649_s_at",0.9116561917482,0.630458645145704,-0.487835805033424,-5.82443041387054,-0.241669132318284,"STK35","serine/threonine kinase 35",TRUE
+"1562254_at",0.912141993216912,0.631674860575372,-0.486091991309885,-5.8252482627673,-0.316055863147549,"STK35","serine/threonine kinase 35",TRUE
+"232006_at",0.957430653957785,0.807765466443906,-0.246237213002546,-5.91019457029935,-0.137666858156176,"STK35","serine/threonine kinase 35",TRUE
+"1553673_at",0.981557175782601,0.91236794202922,-0.11131609065914,-5.93364995061945,-0.0423248885010548,"STK35","serine/threonine kinase 35",TRUE
+"234005_x_at",0.71242055183987,0.186570984135065,-1.36301269168692,-5.07318850683255,-0.4208380876559,"STK36","serine/threonine kinase 36",TRUE
+"231806_s_at",0.808328926947236,0.351332942294908,-0.952069893317386,-5.50757936028199,-0.338620114157912,"STK36","serine/threonine kinase 36",TRUE
+"226166_x_at",0.907851211906426,0.617405242109129,-0.506650154944484,-5.81542460581011,-0.172436984680925,"STK36","serine/threonine kinase 36",TRUE
+"1557145_at",0.690823350461169,0.160451980186336,1.45223218569087,-4.96157967983259,0.677299091203758,"STK38","serine/threonine kinase 38",TRUE
+"202951_at",0.734730148360473,0.219383594158397,1.26395201720864,-5.19014971924834,0.509839071868473,"STK38","serine/threonine kinase 38",TRUE
+"216727_at",0.769258076576208,0.276392335662015,1.11596972204657,-5.35064876584388,0.456383573521126,"STK38","serine/threonine kinase 38",TRUE
+"216451_at",0.820536502908875,0.380186281376277,0.895422669920314,-5.55653297259127,0.503465958486162,"STK38","serine/threonine kinase 38",TRUE
+"1553117_a_at",0.829803290928719,0.401350633037337,0.855648968428696,-5.58924343042661,0.378160559882618,"STK38","serine/threonine kinase 38",TRUE
+"212565_at",0.955615759137826,0.79665233290356,0.260804013768193,-5.90660825852614,0.136470545278422,"STK38L","serine/threonine kinase 38 like",TRUE
+"212572_at",0.975398143273847,0.881136891776361,0.151263170211946,-5.92854535089261,0.0789969570550699,"STK38L","serine/threonine kinase 38 like",TRUE
+"202786_at",0.910967291330762,0.628654903871988,-0.490424844572753,-5.82321087500127,-0.196808710110041,"STK39","serine/threonine kinase 39",TRUE
+"205411_at",0.730582944968624,0.213181898564781,1.28174841452149,-5.16968894692262,0.52891135296473,"STK4","serine/threonine kinase 4",TRUE
+"243981_at",0.769847953580141,0.277813893950874,1.11258212458667,-5.35411749309843,1.19424780809509,"STK4","serine/threonine kinase 4",TRUE
+"236259_at",0.859675188316647,0.477823119335866,0.722037618999866,-5.68889973177123,0.238688462984245,"STK4","serine/threonine kinase 4",TRUE
+"223746_at",0.861659105448003,0.483426925238137,0.712771255689555,-5.69521847571703,0.333057877771469,"STK4","serine/threonine kinase 4",TRUE
+"211085_s_at",0.899808883319249,0.593225765907081,0.542003441028917,-5.79760413063011,0.249217500527142,"STK4","serine/threonine kinase 4",TRUE
+"225364_at",0.925091998149497,0.675998182022256,0.423520974222086,-5.85269457883732,0.165301906511772,"STK4","serine/threonine kinase 4",TRUE
+"1569791_at",0.965992617204023,0.840907682415915,-0.203103612162933,-5.9196115510491,-0.0729667599297432,"STK4","serine/threonine kinase 4",TRUE
+"236695_at",0.907758923401223,0.617176451021375,0.506981558081924,-5.81526299353103,0.308186376222533,"STK4-AS1","STK4 antisense RNA 1 (head to head)",TRUE
+"223852_s_at",0.706453371274998,0.178451349075062,-1.38961906327395,-5.04051664852576,-0.690109428310211,"STK40","serine/threonine kinase 40",TRUE
+"225015_s_at",0.89961817630669,0.590510966561013,-0.546015952047366,-5.79550769423655,-0.230425263281822,"STK40","serine/threonine kinase 40",TRUE
+"1554787_at",0.875970776787636,0.524460967135679,0.646713349523577,-5.7380027566062,0.482798087058638,"STKLD1","serine/threonine kinase like domain containing 1",TRUE
+"236805_at",0.989190625296248,0.947354474422707,0.066781663177506,-5.93751151464289,0.0350045258733607,"STKLD1","serine/threonine kinase like domain containing 1",TRUE
+"200783_s_at",0.896115372949367,0.577596445141937,0.565230064037222,-5.78526076756589,0.20381768799291,"STMN1","stathmin 1",TRUE
+"1552803_a_at",0.937113154905832,0.720044651336106,0.36300042728224,-5.87570650890851,0.276485799402272,"STMN1","stathmin 1",TRUE
+"203000_at",0.895457620469779,0.574118213550621,0.570441608502036,-5.78242219072788,0.37380379384251,"STMN2","stathmin 2",TRUE
+"203001_s_at",0.904832003218088,0.610030371171268,0.517361885070948,-5.81014875910964,0.3671625978713,"STMN2","stathmin 2",TRUE
+"222557_at",0.869850840015332,0.507624516032816,-0.673451993693643,-5.7211639182507,-0.731697269530304,"STMN3","stathmin 3",TRUE
+"218207_s_at",0.941620452688332,0.73857143326089,-0.337964168780974,-5.88420384684167,-0.359720820366307,"STMN3","stathmin 3",TRUE
+"221236_s_at",0.827525258118421,0.396334273600164,0.864950846868284,-5.58171714042689,0.70619548007565,"STMN4","stathmin 4",TRUE
+"236812_at",0.876694463461022,0.525695985085864,-0.644770739430484,-5.73920062114545,-0.467879270718963,"STMN4","stathmin 4",TRUE
+"201061_s_at",0.65284137151906,0.122172529213195,-1.60718354114357,-4.75427360773387,-1.38744719090775,"STOM","stomatin",TRUE
+"201060_x_at",0.732582817014232,0.216912459077901,-1.27099622958258,-5.18208010119871,-1.11489985654805,"STOM","stomatin",TRUE
+"201062_at",0.942502815705589,0.742141053325345,-0.333166045853746,-5.88576380093765,-0.260971252656143,"STOM","stomatin",TRUE
+"1556320_at",0.497885178357455,0.0309795222089083,2.30388486611249,-3.64007598432779,0.632696106892933,"STOML1","stomatin like 1",TRUE
+"204701_s_at",0.933336329621599,0.705089378872842,0.383383422677375,-5.8683460209918,0.304781260534388,"STOML1","stomatin like 1",TRUE
+"33736_at",0.94677940770163,0.758738728025594,-0.310958581166193,-5.89269622522225,-0.112460373662637,"STOML1","stomatin like 1",TRUE
+"215416_s_at",0.629618998226163,0.10055860864641,-1.71361217306092,-4.60248008130071,-0.646895529181043,"STOML2","stomatin like 2",TRUE
+"1553794_at",0.671298718565642,0.137150825096856,1.54235138867879,-4.84303817581394,0.936034406947223,"STOML3","stomatin like 3",TRUE
+"213413_at",0.801892820429336,0.339461399516715,0.976287955235599,-5.48581112006615,0.933770575649873,"STON1","stonin 1",TRUE
+"231795_at",0.896229101808264,0.579751132033556,0.562009553375747,-5.78700225762728,0.377311849319953,"STON1","stonin 1",TRUE
+"220190_s_at",0.97928472590149,0.899942691519976,-0.127183082993324,-5.93180804298011,-0.0865310980282645,"STON1-GTF2A1L///GTF2A1L","STON1-GTF2A1L readthrough///general transcription factor IIA subunit 1 like",TRUE
+"227461_at",0.783297797848606,0.305928538159499,1.04801804418228,-5.41842871007897,1.1693143850493,"STON2","stonin 2",TRUE
+"235852_at",0.8920930097751,0.563900018137014,0.585845350601445,-5.77388473722467,0.74446534369187,"STON2","stonin 2",TRUE
+"242583_at",0.962351204352784,0.828526330296213,0.219167029723763,-5.91631484295821,0.161105591463249,"STON2","stonin 2",TRUE
+"1552543_a_at",0.963796115120365,0.834643415959426,0.211223693152735,-5.91797627421061,0.0986704523385971,"STON2","stonin 2",TRUE
+"1553202_at",0.817055852876968,0.36940818486078,-0.916236544818759,-5.53886735389777,-0.703238774838878,"STOX1","storkhead box 1",TRUE
+"229378_at",0.982844899319041,0.916420586087109,0.106147408043075,-5.93419709751134,0.094180135078509,"STOX1","storkhead box 1",TRUE
+"231969_at",0.597654932724127,0.0750413049868198,1.8680229256718,-4.36951261631398,1.96512854799198,"STOX2","storkhead box 2",TRUE
+"226822_at",0.677013732819214,0.144059406771848,1.51440407732105,-4.88041073497494,1.17137093184372,"STOX2","storkhead box 2",TRUE
+"234317_s_at",0.704758933939989,0.176661496042266,1.39561290722496,-5.03308413333017,1.26978636746756,"STOX2","storkhead box 2",TRUE
+"234319_at",0.854400503339099,0.465365429528127,-0.7428682859676,-5.67441228662835,-0.577632545340508,"STOX2","storkhead box 2",TRUE
+"227694_at",0.63616483035166,0.10766224371731,1.67666545817679,-4.65601316323422,0.712527205978147,"STPG1","sperm tail PG-rich repeat containing 1",TRUE
+"233693_at",0.923050713409153,0.670261497424698,0.431518031049245,-5.8493932416471,0.375656873312932,"STPG1","sperm tail PG-rich repeat containing 1",TRUE
+"1555096_at",0.822812833182588,0.387893303656344,0.880776241933685,-5.56873881111319,0.386214076845651,"STPG2","sperm tail PG-rich repeat containing 2",TRUE
+"1566908_at",0.98539961718117,0.928522720857756,-0.0907295652533446,-5.93567484337379,-0.026558222733021,"STPG3","sperm-tail PG-rich repeat containing 3",TRUE
+"209478_at",0.493519901382617,0.0299226058177115,-2.320244786495,-3.61087009396555,-1.18749932336125,"STRA13","stimulated by retinoic acid 13",TRUE
+"221701_s_at",0.109433493286707,0.000526130599206526,4.0512624577265,-0.0900819129072783,2.21707975003982,"STRA6","stimulated by retinoic acid 6",TRUE
+"1569335_a_at",0.529654081375395,0.0413413342070769,2.16597656829943,-3.88135323122193,0.846202204613162,"STRA6","stimulated by retinoic acid 6",TRUE
+"1569334_at",0.610033432202476,0.0824858302744586,1.81879691510096,-4.44536211793442,1.09715514957517,"STRA6","stimulated by retinoic acid 6",TRUE
+"52169_at",0.928131870017533,0.684143952911689,-0.412213507433225,-5.85725890436731,-0.144444824418692,"STRADA","STE20-related kinase adaptor alpha",TRUE
+"221554_at",0.939976205834042,0.730286915667882,-0.349131314787501,-5.88048781442136,-0.155524920696713,"STRADA","STE20-related kinase adaptor alpha",TRUE
+"1557528_at",0.942856731597582,0.743956704975715,0.33072859253914,-5.88654780718901,0.118934792336199,"STRADA","STE20-related kinase adaptor alpha",TRUE
+"223266_at",0.766086095192912,0.266476866471945,-1.13995962852937,-5.32581760492869,-0.665246592195555,"STRADB","STE20-related kinase adaptor beta",TRUE
+"1558002_at",0.789206802209792,0.315394030695637,1.02723558867661,-5.4383957112369,0.553099745871147,"STRAP","serine/threonine kinase receptor associated protein",TRUE
+"200870_at",0.954685039946564,0.793692164499507,0.264693736239878,-5.90561598445507,0.0765389697708354,"STRAP","serine/threonine kinase receptor associated protein",TRUE
+"233252_s_at",0.599731655615302,0.0761746804989781,-1.86026180288091,-4.38156694551028,-0.986902052374498,"STRBP","spermatid perinuclear RNA binding protein",TRUE
+"223246_s_at",0.62952950109137,0.100376836483705,-1.71458634328978,-4.60105673060337,-0.817069162214525,"STRBP","spermatid perinuclear RNA binding protein",TRUE
+"223245_at",0.643215798394085,0.113717840829855,-1.64676500069618,-4.69868846823543,-0.685618680267606,"STRBP","spermatid perinuclear RNA binding protein",TRUE
+"229513_at",0.704148059811236,0.176043749099198,-1.39769283583174,-5.03049878990887,-0.592573100237029,"STRBP","spermatid perinuclear RNA binding protein",TRUE
+"233251_at",0.73936001229895,0.227041417667463,-1.24250181447313,-5.21448549214168,-0.925811699768946,"STRBP","spermatid perinuclear RNA binding protein",TRUE
+"225226_at",0.995111934465262,0.977392794144058,0.0286594288171302,-5.9392834331018,0.00824604864090261,"STRIP1","striatin interacting protein 1",TRUE
+"231880_at",0.643498555465841,0.113811267148691,1.64631431318872,-4.69932722524092,1.50235956720704,"STRIP2","striatin interacting protein 2",TRUE
+"1555292_at",0.672329541745581,0.138169644121104,1.53815820933827,-4.84868010104137,1.0728726086246,"STRIP2","striatin interacting protein 2",TRUE
+"244354_at",0.0985170196189519,0.000440341439911773,4.12397605812075,0.0669322332769626,1.42581567525478,"STRN","striatin",TRUE
+"215287_at",0.117874145553551,0.000648927623440675,3.96546973790518,-0.275141063281767,1.42126585698674,"STRN","striatin",TRUE
+"242989_at",0.130547951137661,0.000797494571193027,3.88101883597106,-0.457002033935892,1.25685628269032,"STRN","striatin",TRUE
+"205520_at",0.347515673982638,0.0090319117097271,2.86145222430106,-2.5856423609149,0.986773401762646,"STRN","striatin",TRUE
+"236388_at",0.358427723880268,0.0101631789139248,2.80978717620751,-2.68783299931163,0.896491545750886,"STRN","striatin",TRUE
+"227422_at",0.376502947045791,0.0115051742317224,2.75516142678822,-2.79500899220724,0.708160113674394,"STRN","striatin",TRUE
+"230734_x_at",0.458513895161332,0.022869088104343,2.44543729414906,-3.38353604015029,0.811569700586434,"STRN","striatin",TRUE
+"236980_at",0.614178202960275,0.0851824466138927,1.80191433822863,-4.47104024674766,0.519456762308238,"STRN","striatin",TRUE
+"1569815_x_at",0.623503825356688,0.0942921816481446,1.74809802968835,-4.55172679109703,0.901573453271297,"STRN","striatin",TRUE
+"1569813_at",0.647754107214051,0.119231771338255,1.62068303366255,-4.7354331566772,1.3649170407154,"STRN","striatin",TRUE
+"204496_at",0.497725944448536,0.0306578245612776,-2.3088094835193,-3.63129710676065,-0.673937471203873,"STRN3","striatin 3",TRUE
+"215505_s_at",0.893864194031613,0.569440946361502,-0.577474985378159,-5.77855129752996,-0.474296925284256,"STRN3","striatin 3",TRUE
+"217903_at",0.76711764189372,0.268960043062015,-1.13389114318363,-5.33214295790175,-0.413966462979651,"STRN4","striatin 4",TRUE
+"203767_s_at",0.860995621204954,0.481086716558049,-0.716633341299618,-5.69259435335385,-0.6186181821051,"STS","steroid sulfatase (microsomal), isozyme S",TRUE
+"203770_s_at",0.861720231299371,0.483950277499378,-0.711909044865074,-5.69580246791128,-1.12550161352567,"STS","steroid sulfatase (microsomal), isozyme S",TRUE
+"203768_s_at",0.88767000285873,0.552468786129122,-0.603249174998567,-5.76397412813633,-0.525523697848605,"STS","steroid sulfatase (microsomal), isozyme S",TRUE
+"203769_s_at",0.974292018919448,0.874470532198778,0.15982045922091,-5.92725028441352,0.11174365333852,"STS","steroid sulfatase (microsomal), isozyme S",TRUE
+"202223_at",0.827639990106867,0.396449773038845,0.864735825001593,-5.58189197279788,0.573778890130765,"STT3A","STT3A, catalytic subunit of the oligosaccharyltransferase complex",TRUE
+"224700_at",0.999328749224215,0.997805358644531,0.00278177919452969,-5.93967971171139,0.000793627688620901,"STT3B","STT3B, catalytic subunit of the oligosaccharyltransferase complex",TRUE
+"233049_x_at",0.630603891142543,0.101976688568174,-1.70606330561925,-4.61348912061074,-0.565782415986471,"STUB1","STIP1 homology and U-box containing protein 1",TRUE
+"227625_s_at",0.673190784310977,0.138823608652824,-1.53548006992507,-4.85227716777721,-0.41719976022258,"STUB1","STIP1 homology and U-box containing protein 1",TRUE
+"217934_x_at",0.68041487556515,0.148112614532433,-1.49851538825445,-4.90141458502082,-0.494536192959181,"STUB1","STIP1 homology and U-box containing protein 1",TRUE
+"232104_at",0.774230543658252,0.287021201400155,-1.09094030570147,-5.37605648040287,-0.734675985207883,"STUM","stum, mechanosensory transduction mediator homolog",TRUE
+"213925_at",0.973071267819624,0.870354278796756,-0.165110363915211,-5.92641415854345,-0.0940055096607715,"STUM","stum, mechanosensory transduction mediator homolog",TRUE
+"212625_at",0.835838027302116,0.41547205475089,0.829856336606323,-5.60971543060557,0.300114914619465,"STX10","syntaxin 10",TRUE
+"235670_at",0.786455312223125,0.312125871117709,1.03436083946512,-5.43159063102474,0.448748808842527,"STX11","syntaxin 11",TRUE
+"210190_at",0.804658857755908,0.343694616241797,0.967586867581482,-5.49368952226223,0.478911122408102,"STX11","syntaxin 11",TRUE
+"212111_at",0.667641453131852,0.134065578672786,-1.55520804528114,-4.82566386458284,-0.370803353108405,"STX12","syntaxin 12",TRUE
+"212112_s_at",0.716472449896956,0.192215703631142,-1.34505041269926,-5.09494768933823,-0.400574944964601,"STX12","syntaxin 12",TRUE
+"221500_s_at",0.663819586595936,0.131935652251195,-1.56422713171997,-4.81340774750842,-0.724277205950489,"STX16","syntaxin 16",TRUE
+"1558249_s_at",0.668010713423865,0.134176381432481,-1.55474210636689,-4.82629551621946,-0.679816020505326,"STX16","syntaxin 16",TRUE
+"221499_s_at",0.784448016670989,0.307523708995445,-1.04448417656792,-5.42184931807626,-0.406095781514304,"STX16","syntaxin 16",TRUE
+"221638_s_at",0.870684240983489,0.509906509467547,-0.669799271194665,-5.72350278798673,-0.339137384594595,"STX16","syntaxin 16",TRUE
+"226662_at",0.671298718565642,0.137277753481785,-1.54182758960061,-4.84374361260552,-0.505108593790981,"STX17","syntaxin 17",TRUE
+"226655_at",0.726082405428554,0.205130963321912,-1.30545754480477,-5.14205226706507,-0.793533705623982,"STX17","syntaxin 17",TRUE
+"228091_at",0.73957587762701,0.227843370459058,-1.24028759366919,-5.21697719699926,-0.505394416442267,"STX17","syntaxin 17",TRUE
+"218666_s_at",0.867216713941453,0.499306056235223,-0.686845944038626,-5.71248356503216,-0.237874088634191,"STX17","syntaxin 17",TRUE
+"222708_s_at",0.897560972979555,0.584421135849717,-0.555050019424519,-5.79073264816808,-0.204146045145462,"STX17","syntaxin 17",TRUE
+"1558689_a_at",0.915074968835645,0.64210061599231,-0.4712053440901,-5.83211349570275,-0.489445076223064,"STX17-AS1","STX17 antisense RNA 1",TRUE
+"1558688_at",0.978608697028954,0.89656128473484,-0.131506744670531,-5.93126370813957,-0.0486191095164195,"STX17-AS1","STX17 antisense RNA 1",TRUE
+"218763_at",0.589729941648868,0.0678984907668884,-1.91943675241373,-4.28877023928607,-0.844774769595809,"STX18","syntaxin 18",TRUE
+"1569330_at",0.996261754016157,0.981787692396542,-0.0230868035082973,-5.9394238791934,-0.0195897335341826,"STX18-AS1","STX18 antisense RNA 1 (head to head)",TRUE
+"1555173_at",0.137844713664596,0.00090245682704868,3.83028693568372,-0.56606286035429,2.90887515284116,"STX19","syntaxin 19",TRUE
+"204729_s_at",0.997293485734839,0.986331009558769,-0.0173267720125699,-5.93953725716135,-0.0072186015562643,"STX1A","syntaxin 1A",TRUE
+"230691_at",0.99783553534859,0.989667514879567,-0.013097134133946,-5.93959993275812,-0.00374685058891355,"STX1B","syntaxin 1B",TRUE
+"207346_at",0.729083413548563,0.211210757051192,1.28748830933814,-5.16303770576452,1.09538531711057,"STX2","syntaxin 2",TRUE
+"213434_at",0.955730092376044,0.797472422935027,-0.259727128009513,-5.90688039433897,-0.111087648519829,"STX2","syntaxin 2",TRUE
+"216985_s_at",0.658545398168709,0.12672087151216,-1.58682926235544,-4.78244937995724,-0.846644961233984,"STX3","syntaxin 3",TRUE
+"209238_at",0.674325549770726,0.140713085531066,-1.52780010757179,-4.8625646890017,-0.603972254690387,"STX3","syntaxin 3",TRUE
+"235483_at",0.760463372361683,0.259494303443466,1.15725008712147,-5.30763236866931,0.692772846035277,"STX3","syntaxin 3",TRUE
+"203530_s_at",0.666643938027574,0.133373000712457,-1.55812765320547,-4.8217024925887,-0.427004577176623,"STX4","syntaxin 4",TRUE
+"229395_at",0.996261754016157,0.98179602092531,0.0230762439024659,-5.93942411661284,0.00836551757103621,"STX4","syntaxin 4",TRUE
+"203330_s_at",0.803275622655718,0.341297347712095,-0.972505226264414,-5.48924409989125,-0.318343736175169,"STX5","syntaxin 5",TRUE
+"212800_at",0.474590658259886,0.0259885584056717,-2.38621076629426,-3.49191389339701,-0.865335416215933,"STX6","syntaxin 6",TRUE
+"212799_at",0.645870209706894,0.117054008376509,-1.63086082482134,-4.72114820035956,-0.592837205543008,"STX6","syntaxin 6",TRUE
+"1552618_at",0.757619650696855,0.253764238585115,-1.17169809417317,-5.29225249483924,-0.471501355764575,"STX6","syntaxin 6",TRUE
+"214441_at",0.871744769522775,0.514090512732744,-0.66312570881238,-5.72774446207028,-0.226953025202075,"STX6","syntaxin 6",TRUE
+"244041_at",0.929332398252332,0.689343982705395,0.405023715285941,-5.86009791284558,0.324862187461389,"STX6","syntaxin 6",TRUE
+"212631_at",0.364513221153898,0.0106377335375386,2.78972715842074,-2.72729714495039,0.88560059320772,"STX7","syntaxin 7",TRUE
+"212632_at",0.514490373584066,0.0347493671003189,2.24942076041877,-3.73643100131805,0.735925318392056,"STX7","syntaxin 7",TRUE
+"229214_at",0.650490742096872,0.120541136536925,1.61463841971134,-4.74388434434977,1.40375697999638,"STX7","syntaxin 7",TRUE
+"203457_at",0.726480797733202,0.205510274309235,1.30432447200866,-5.14338281547889,0.471787397915498,"STX7","syntaxin 7",TRUE
+"204690_at",0.78969417320323,0.317784201167215,1.02205729409045,-5.44331467577422,0.392311576536935,"STX8","syntaxin 8",TRUE
+"1570357_at",0.993461753950386,0.969075063408869,0.0392088054683139,-5.93893473151909,0.028896887357476,"STX8","syntaxin 8",TRUE
+"202260_s_at",0.88113080359582,0.537391562514354,-0.626495998541075,-5.75029966997167,-0.333807815918075,"STXBP1","syntaxin binding protein 1",TRUE
+"209367_at",0.677013732819214,0.144232936009636,1.51371638924389,-4.88132348250958,1.22063413771946,"STXBP2","syntaxin binding protein 2",TRUE
+"1570420_at",0.797508506396963,0.330993824215489,0.993918557477987,-5.4696505839768,0.725806208934289,"STXBP2","syntaxin binding protein 2",TRUE
+"203310_at",0.838808499746386,0.42424456229514,-0.814111763508592,-5.62192397475909,-0.317331819033326,"STXBP3","syntaxin binding protein 3",TRUE
+"1560486_at",0.932625096890813,0.702328602130225,0.387164058622021,-5.86693721223319,0.217926832418589,"STXBP3","syntaxin binding protein 3",TRUE
+"237706_at",0.425751189365875,0.018228212026029,-2.54917670132322,-3.1903110097714,-1.73612487083523,"STXBP4","syntaxin binding protein 4",TRUE
+"244404_at",0.801892820429336,0.339544959959023,-0.976115485955825,-5.48596790733872,-0.567456764858162,"STXBP4","syntaxin binding protein 4",TRUE
+"1554329_x_at",0.819780516863333,0.377441959152109,0.900684958481945,-5.55210206998016,0.536752644151722,"STXBP4","syntaxin binding protein 4",TRUE
+"1554328_at",0.8877101263145,0.552683517505138,0.602920529787702,-5.76416387110867,0.554953876130361,"STXBP4","syntaxin binding protein 4",TRUE
+"235227_at",0.61760967235709,0.0878405031133118,-1.78571914752547,-4.49550960558513,-0.93703222436231,"STXBP5","syntaxin binding protein 5",TRUE
+"226794_at",0.884769004468037,0.544574923581837,0.615377722825471,-5.75690195063301,0.368482357629924,"STXBP5","syntaxin binding protein 5",TRUE
+"243904_at",0.979657792151916,0.903186907391443,-0.123037175294475,-5.93231293641461,-0.0514251677927584,"STXBP5","syntaxin binding protein 5",TRUE
+"1557890_at",0.713506394788546,0.188284778491251,1.35751441255901,-5.0798746390504,1.03119280653922,"STXBP5-AS1","STXBP5 antisense RNA 1",TRUE
+"238685_at",0.859502367311367,0.477432910873279,-0.722685216149712,-5.68845523246494,-0.530755233512541,"STXBP5-AS1","STXBP5 antisense RNA 1",TRUE
+"1557891_s_at",0.912051899719319,0.631518216957924,0.486316501596198,-5.82514312795511,0.401410726367978,"STXBP5-AS1","STXBP5 antisense RNA 1",TRUE
+"240236_at",0.810988005281578,0.354995444543283,-0.944710723329903,-5.51409494360212,-1.07949083777019,"STXBP5L","syntaxin binding protein 5 like",TRUE
+"215518_at",0.940567117317801,0.733774055639679,0.344425377863771,-5.88206834301304,0.15854367183996,"STXBP5L","syntaxin binding protein 5 like",TRUE
+"1568896_at",0.972473496102009,0.86728450193745,-0.16905854772615,-5.92577241050812,-0.148598200953457,"STXBP5L","syntaxin binding protein 5 like",TRUE
+"220995_at",0.585036027492332,0.0652032489696984,1.94007787710201,-4.25592679195001,0.692277905552157,"STXBP6","syntaxin binding protein 6",TRUE
+"220994_s_at",0.805859691692007,0.346148668650805,-0.962576201517157,-5.49819720532728,-1.07185146970412,"STXBP6","syntaxin binding protein 6",TRUE
+"226462_at",0.897024165042344,0.583049822891505,0.557090748935634,-5.78964346762521,0.721340475205922,"STXBP6","syntaxin binding protein 6",TRUE
+"230560_at",0.985361089461736,0.927331802959575,-0.0922457061637574,-5.93553977861857,-0.148348058055315,"STXBP6","syntaxin binding protein 6",TRUE
+"221696_s_at",0.506191505604384,0.0332162430922527,2.27088534995258,-3.6986194527384,1.53186707272378,"STYK1","serine/threonine/tyrosine kinase 1",TRUE
+"220030_at",0.55937703282623,0.0534657126558274,2.03982892218142,-4.09386261581756,2.24754722865028,"STYK1","serine/threonine/tyrosine kinase 1",TRUE
+"242408_at",0.539609110035715,0.044520835763532,-2.12996646309955,-3.94284430276822,-0.819539303440739,"STYX","serine/threonine/tyrosine interacting protein",TRUE
+"228853_at",0.683970477958028,0.152978026764403,-1.47990489210216,-4.9257901631373,-0.461712905119727,"STYX","serine/threonine/tyrosine interacting protein",TRUE
+"235180_at",0.750269073377092,0.24321479755895,-1.19894635356028,-5.26279343404474,-0.390653477494153,"STYX","serine/threonine/tyrosine interacting protein",TRUE
+"244030_at",0.84982708915917,0.451267121711169,-0.766846205829794,-5.65725285089392,-0.447674363639917,"STYX","serine/threonine/tyrosine interacting protein",TRUE
+"232353_s_at",0.737488397392592,0.223683747548569,-1.25183774886977,-5.20393758157864,-0.510189410210439,"STYXL1","serine/threonine/tyrosine interacting-like 1",TRUE
+"230370_x_at",0.803583569469174,0.341866529129348,-0.971335332185414,-5.49030336463051,-0.389769896019033,"STYXL1","serine/threonine/tyrosine interacting-like 1",TRUE
+"218321_x_at",0.853297110808539,0.460080836767391,-0.751804474935071,-5.66807755018974,-0.294588790197174,"STYXL1","serine/threonine/tyrosine interacting-like 1",TRUE
+"233982_x_at",0.92777930247318,0.683209690064378,-0.413507595046477,-5.85674269353746,-0.161017007297101,"STYXL1","serine/threonine/tyrosine interacting-like 1",TRUE
+"222591_at",0.931188266172628,0.695150988058564,-0.397020263619571,-5.8632003680383,-0.116194531354558,"STYXL1","serine/threonine/tyrosine interacting-like 1",TRUE
+"237784_at",0.724623760403195,0.202011870109244,1.31483717197385,-5.13100040046591,0.913032863246099,"SUB1","SUB1 homolog, transcriptional regulator",TRUE
+"224586_x_at",0.81145007894578,0.355613266421945,0.943474377317165,-5.51518501827143,0.254744975450125,"SUB1","SUB1 homolog, transcriptional regulator",TRUE
+"214512_s_at",0.832792886465252,0.409872283604388,0.84001650444743,-5.60172099041061,0.249288881343253,"SUB1","SUB1 homolog, transcriptional regulator",TRUE
+"212857_x_at",0.893334037681196,0.56793679718878,0.579743077217326,-5.77729323454762,0.136123287444802,"SUB1","SUB1 homolog, transcriptional regulator",TRUE
+"224587_at",0.939976205834042,0.730420800818768,-0.348950487435028,-5.88054893846209,-0.166053343122281,"SUB1","SUB1 homolog, transcriptional regulator",TRUE
+"221727_at",0.963838474214007,0.834744937009266,0.211091981710944,-5.91800330840966,0.0980561742242916,"SUB1","SUB1 homolog, transcriptional regulator",TRUE
+"202930_s_at",0.947894114837368,0.762545491486178,0.305888008524347,-5.8942126891889,0.115497619065279,"SUCLA2","succinate-CoA ligase ADP-forming beta subunit",TRUE
+"1569859_at",0.857287594027564,0.472382319986619,0.731095411105552,-5.68264823262234,0.440149388367724,"SUCLA2-AS1","SUCLA2 antisense RNA 1",TRUE
+"217874_at",0.433834057207331,0.0196465135006008,-2.51508307256864,-3.25427500857439,-0.660974525634639,"SUCLG1","succinate-CoA ligase alpha subunit",TRUE
+"244638_at",0.985709215004606,0.93092737930883,-0.0876688884557319,-5.9359406876056,-0.0360206970116144,"SUCLG1","succinate-CoA ligase alpha subunit",TRUE
+"215774_s_at",0.729273475042162,0.211456978096864,1.28676906717778,-5.16387253101728,1.09516472672438,"SUCLG2","succinate-CoA ligase GDP-forming beta subunit",TRUE
+"215772_x_at",0.755049574909504,0.248691239383958,-1.18469330370806,-5.27827658982607,-0.446105062970126,"SUCLG2","succinate-CoA ligase GDP-forming beta subunit",TRUE
+"214835_s_at",0.823074246722209,0.389690239833796,-0.87738870513421,-5.57153529158851,-0.365184584745627,"SUCLG2","succinate-CoA ligase GDP-forming beta subunit",TRUE
+"212459_x_at",0.84571977676742,0.443457481917237,-0.780323479256708,-5.6473820155167,-0.308402322142847,"SUCLG2","succinate-CoA ligase GDP-forming beta subunit",TRUE
+"1557338_x_at",0.76719388846109,0.269119775015255,1.1335021943913,-5.33254735449044,0.996378773931818,"SUCLG2-AS1","SUCLG2 antisense RNA 1 (head to head)",TRUE
+"1564097_at",0.790817398514927,0.320506469805209,1.01619263069909,-5.44885850201355,0.668979916112702,"SUCLG2-AS1","SUCLG2 antisense RNA 1 (head to head)",TRUE
+"1557336_at",0.974982245454858,0.878235445791453,0.154986158941355,-5.9279906466537,0.124854713405807,"SUCLG2-AS1","SUCLG2 antisense RNA 1 (head to head)",TRUE
+"223939_at",0.985498770484702,0.929725154256464,-0.0891989851375317,-5.93580892584361,-0.0653873233350559,"SUCNR1","succinate receptor 1",TRUE
+"203429_s_at",0.784789297644843,0.308903260636184,-1.04143842534658,-5.42478911447447,-0.415335692679628,"SUCO","SUN domain containing ossification factor",TRUE
+"224974_at",0.88191340888295,0.538906757947497,0.624144224836694,-5.75170570171908,0.259385044000476,"SUDS3","SDS3 homolog, SIN3A corepressor complex component",TRUE
+"233841_s_at",0.895213601869362,0.573250394708479,0.571744374695573,-5.78170866727892,0.258771898414278,"SUDS3","SDS3 homolog, SIN3A corepressor complex component",TRUE
+"224201_s_at",0.627021415091472,0.0975247901152263,-1.73007165136633,-4.57835025928707,-1.47915516322276,"SUFU","SUFU negative regulator of hedgehog signaling",TRUE
+"222749_at",0.804966190665093,0.344070497631127,-0.966817817022348,-5.49438276245821,-0.398484378419176,"SUFU","SUFU negative regulator of hedgehog signaling",TRUE
+"224203_at",0.807278514426025,0.348558278739006,0.957679755542304,-5.50258146321319,0.310382110910428,"SUFU","SUFU negative regulator of hedgehog signaling",TRUE
+"224202_at",0.974536463688956,0.875263386773062,0.158802081897007,-5.92740813255842,0.146385020598551,"SUFU","SUFU negative regulator of hedgehog signaling",TRUE
+"219655_at",0.347515673982638,0.00902340247036027,2.86186372960765,-2.58482531747537,2.66083574004848,"SUGCT","succinyl-CoA:glutarate-CoA transferase",TRUE
+"209547_s_at",0.732963666545614,0.217281589440269,1.26994008351382,-5.18329243022803,0.613243823587842,"SUGP1","SURP and G-patch domain containing 1",TRUE
+"215004_s_at",0.955515814503015,0.796113838057272,0.261511299477561,-5.90642891434765,0.0650066010955026,"SUGP1","SURP and G-patch domain containing 1",TRUE
+"212001_at",0.542397752248982,0.0455643873082684,-2.11865246489355,-3.96202978963901,-0.649724116480096,"SUGP2","SURP and G-patch domain containing 2",TRUE
+"64371_at",0.619415519928971,0.0896177555515874,-1.77512466037733,-4.51142968465203,-0.698034920740342,"SUGP2","SURP and G-patch domain containing 2",TRUE
+"212000_at",0.747587302711183,0.239436602789779,-1.20892060435039,-5.25186264290498,-0.424070432535995,"SUGP2","SURP and G-patch domain containing 2",TRUE
+"213505_s_at",0.776983560547865,0.296071941198151,-1.07014937977447,-5.39677099721484,-0.300048213730342,"SUGP2","SURP and G-patch domain containing 2",TRUE
+"214092_x_at",0.84772210282622,0.447010084656947,-0.774174933481959,-5.65190537730117,-0.267279422979842,"SUGP2","SURP and G-patch domain containing 2",TRUE
+"224309_s_at",0.612420348961838,0.0842496727682404,1.8077011374828,-4.4622581117798,0.532637030975545,"SUGT1","SGT1 homolog, MIS12 kinetochore complex assembly cochaperone",TRUE
+"223329_x_at",0.622917527985155,0.0934378361803055,1.75295051424252,-4.54452520340947,0.446088520547523,"SUGT1","SGT1 homolog, MIS12 kinetochore complex assembly cochaperone",TRUE
+"223330_s_at",0.914021824020248,0.638837311076539,0.475853162659275,-5.82999250094583,0.17700398170671,"SUGT1","SGT1 homolog, MIS12 kinetochore complex assembly cochaperone",TRUE
+"228045_at",0.939481320547208,0.728957050653271,0.350928096588672,-5.87987875811687,0.217945640036432,"SUGT1","SGT1 homolog, MIS12 kinetochore complex assembly cochaperone",TRUE
+"244368_x_at",0.940668681806864,0.734346278078454,0.34365391649579,-5.88232542193814,0.141515844778018,"SUGT1","SGT1 homolog, MIS12 kinetochore complex assembly cochaperone",TRUE
+"234686_at",0.683838837468118,0.15268020701781,1.48103012002249,-4.92432333578631,0.71913972602057,"SUGT1P1","SGT1 homolog, MIS12 kinetochore complex assembly cochaperone pseudogene 1",TRUE
+"1555614_at",0.953983577550391,0.7883293999399,0.271751205883272,-5.90377836532057,0.204289113267016,"SUGT1P1","SGT1 homolog, MIS12 kinetochore complex assembly cochaperone pseudogene 1",TRUE
+"1554142_at",0.597654932724127,0.0743690286664403,-1.87267498387481,-4.36227018718176,-2.5814748200186,"SUGT1P3","SGT1 homolog, MIS12 kinetochore complex assembly cochaperone pseudogene 3",TRUE
+"1554143_a_at",0.67368843181164,0.14027551751575,-1.52957106671161,-4.86019607596598,-0.993555681082031,"SUGT1P3","SGT1 homolog, MIS12 kinetochore complex assembly cochaperone pseudogene 3",TRUE
+"212354_at",0.848675503667458,0.449100094717605,-0.770571600133398,-5.6545405838562,-0.93655008661444,"SULF1","sulfatase 1",TRUE
+"212353_at",0.903919439852106,0.605798533634445,0.523536188447416,-5.80705886488641,0.487342429830758,"SULF1","sulfatase 1",TRUE
+"212344_at",0.9832781796011,0.91849721212455,0.103500066204897,-5.93446727858472,0.113363437128633,"SULF1","sulfatase 1",TRUE
+"224724_at",0.816800680706682,0.368393580546878,0.918216483207596,-5.53716739033025,1.52103778702624,"SULF2","sulfatase 2",TRUE
+"233555_s_at",0.835622813065001,0.415052743199017,0.830614118593144,-5.60912231562358,1.5937011763809,"SULF2","sulfatase 2",TRUE
+"203615_x_at",0.776288326324084,0.293789813411942,-1.07534827684316,-5.39162458825461,-0.655854037304369,"SULT1A1","sulfotransferase family 1A member 1",TRUE
+"215299_x_at",0.882059205223864,0.539428153222409,-0.623335773749439,-5.7521878661959,-0.400893231846567,"SULT1A1","sulfotransferase family 1A member 1",TRUE
+"238995_at",0.925511384407886,0.678067854561179,0.420642714197269,-5.85386792653279,0.155734900015629,"SULT1A1","sulfotransferase family 1A member 1",TRUE
+"211385_x_at",0.8920930097751,0.563712707116901,-0.586129046900857,-5.77372543529007,-0.327084596471515,"SULT1A2","sulfotransferase family 1A member 2",TRUE
+"207122_x_at",0.910159094731364,0.626116211633033,-0.494074584113333,-5.82148099390201,-0.228216867275112,"SULT1A2","sulfotransferase family 1A member 2",TRUE
+"207601_at",0.855405088766616,0.468444943756159,0.737688666058105,-5.67805116970751,0.307061159082918,"SULT1B1","sulfotransferase family 1B member 1",TRUE
+"205343_at",0.687659256779784,0.156679882286008,1.46606488360615,-4.94375805217678,0.906552048867532,"SULT1C2","sulfotransferase family 1C member 2",TRUE
+"240200_at",0.763507239677949,0.26335588537881,1.14764608439887,-5.31776310664303,0.379998569168712,"SULT1C2","sulfotransferase family 1C member 2",TRUE
+"211470_s_at",0.89565571257902,0.574936743768491,0.569213747417492,-5.78309324481067,0.738621214096244,"SULT1C2","sulfotransferase family 1C member 2",TRUE
+"205342_s_at",0.932415412515157,0.701923419726604,-0.387719401972975,-5.86672912234727,-0.377358105020059,"SULT1C2","sulfotransferase family 1C member 2",TRUE
+"1553321_a_at",0.915409740314202,0.643373101986989,-0.469395840000383,-5.8329337376845,-0.351341234522569,"SULT1C4","sulfotransferase family 1C member 4",TRUE
+"222940_at",0.934781502857546,0.710336513814471,-0.376213541624035,-5.87098034932815,-0.341409391965299,"SULT1E1","sulfotransferase family 1E member 1",TRUE
+"219934_s_at",0.98661350081953,0.937663245685763,-0.0790998703466992,-5.93663648869908,-0.0614759664807281,"SULT1E1","sulfotransferase family 1E member 1",TRUE
+"206292_s_at",0.819203514175924,0.376083955535988,0.903298277065058,-5.54989270894145,0.714306602178715,"SULT2A1","sulfotransferase family 2A member 1",TRUE
+"206293_at",0.963379172403332,0.833031736558504,0.213315168456044,-5.91754474208018,0.163113495639849,"SULT2A1","sulfotransferase family 2A member 1",TRUE
+"205759_s_at",0.975242094553739,0.879850925610176,-0.152912983673738,-5.92830119832348,-0.139018160936617,"SULT2B1","sulfotransferase family 2B member 1",TRUE
+"219425_at",0.96827357703393,0.851110280426892,0.189908038271352,-5.92213276913842,0.151543199470149,"SULT4A1","sulfotransferase family 4A member 1",TRUE
+"1561686_at",0.988139605576153,0.943372649285345,0.0718414396957367,-5.9371699668204,0.0373743507323798,"SULT4A1","sulfotransferase family 4A member 1",TRUE
+"226850_at",0.737123149977386,0.223153501428928,-1.25332185605935,-5.2022545642794,-0.482550434073245,"SUMF1","sulfatase modifying factor 1",TRUE
+"225002_s_at",0.987742637880475,0.941769077334712,-0.0738796626277154,-5.93702534019466,-0.0284919906028982,"SUMF2","sulfatase modifying factor 2",TRUE
+"208762_at",0.632949074657601,0.104170792618834,-1.6945574807587,-4.63019865075682,-0.855664158606103,"SUMO1","small ubiquitin-like modifier 1",TRUE
+"211069_s_at",0.904381089098038,0.607242390877582,-0.521427278266642,-5.80811827212153,-0.152654500160608,"SUMO1","small ubiquitin-like modifier 1",TRUE
+"208761_s_at",0.942199057522921,0.739858170102002,-0.336233668219799,-5.88476900677617,-0.0945458985910506,"SUMO1","small ubiquitin-like modifier 1",TRUE
+"200739_s_at",0.859064198633089,0.475781758036446,0.72542893342094,-5.68656779090187,0.346714347923484,"SUMO3","small ubiquitin-like modifier 3",TRUE
+"200740_s_at",0.921312278448293,0.664878096386965,0.439048697519772,-5.84622899616142,0.155495890354539,"SUMO3","small ubiquitin-like modifier 3",TRUE
+"215452_x_at",0.808802470779793,0.351967758340441,0.950790635057462,-5.50871530281429,0.329265997910408,"SUMO4","small ubiquitin-like modifier 4",TRUE
+"212074_at",0.803135302652907,0.340961272490152,0.973196621311599,-5.48861753873656,0.323313055404403,"SUN1","Sad1 and UNC84 domain containing 1",TRUE
+"206487_at",0.837368340567858,0.420817183813186,0.820238538563079,-5.61719923222101,0.773451905588475,"SUN1","Sad1 and UNC84 domain containing 1",TRUE
+"214169_at",0.90770249070865,0.617088277634028,0.507109292299843,-5.81520067505159,0.235564651648803,"SUN1","Sad1 and UNC84 domain containing 1",TRUE
+"230210_at",0.94124316592092,0.736967145677342,0.34012321107594,-5.88349470734037,0.285672621466625,"SUN1","Sad1 and UNC84 domain containing 1",TRUE
+"212144_at",0.865187396415238,0.494421339159046,0.694770074936768,-5.70727120575103,0.518165979429734,"SUN2","Sad1 and UNC84 domain containing 2",TRUE
+"231618_s_at",0.993354935415366,0.968744049832364,0.0396287161750933,-5.93891860863834,0.0274382722995417,"SUN3","Sad1 and UNC84 domain containing 3",TRUE
+"242668_x_at",0.862639573412331,0.486256475602614,0.708116056526668,-5.69836353797135,0.237438029436372,"SUN5","Sad1 and UNC84 domain containing 5",TRUE
+"237188_x_at",0.8943345793428,0.570787474095418,-0.575447161177938,-5.77967204571083,-0.36864726750993,"SUN5","Sad1 and UNC84 domain containing 5",TRUE
+"234504_at",0.961395512423249,0.824890629996664,0.223894974013025,-5.91529696484276,0.152983449146328,"SUN5","Sad1 and UNC84 domain containing 5",TRUE
+"233905_at",0.971242929121865,0.863666930275285,0.173714814547135,-5.92499613553065,0.0971649072717682,"SUN5","Sad1 and UNC84 domain containing 5",TRUE
+"1553030_a_at",0.638134354959023,0.109426565357685,-1.66781027366911,-4.6687125804787,-0.674792646248497,"SUOX","sulfite oxidase",TRUE
+"204067_at",0.767727587789514,0.269948499699605,-1.13148695570679,-5.33464067088293,-0.488997286798083,"SUOX","sulfite oxidase",TRUE
+"217815_at",0.725178543391177,0.203620320039165,-1.30998633860864,-5.13672441568906,-0.413511970374518,"SUPT16H","SPT16 homolog, facilitates chromatin remodeling subunit",TRUE
+"233827_s_at",0.885312914741353,0.546595937015146,-0.612263731901348,-5.758730680543,-0.260245286663006,"SUPT16H","SPT16 homolog, facilitates chromatin remodeling subunit",TRUE
+"221774_x_at",0.698684193803792,0.170022737970909,1.41827657591029,-5.00474224998637,0.427422558618762,"SUPT20H","SPT20 homolog, SAGA complex component",TRUE
+"220408_x_at",0.835881746772981,0.41551769539173,0.829773883755218,-5.60977993579627,0.255806030756721,"SUPT20H","SPT20 homolog, SAGA complex component",TRUE
+"226330_s_at",0.854184492233394,0.464117540485882,0.744972977914966,-5.67292676230081,0.256822636498569,"SUPT20H","SPT20 homolog, SAGA complex component",TRUE
+"216682_s_at",0.889169540970342,0.556676239367441,0.596821819450453,-5.76766683358155,0.288564212305521,"SUPT20H","SPT20 homolog, SAGA complex component",TRUE
+"216717_at",0.990918916504081,0.957238064442085,-0.0542298353341485,-5.9382511904553,-0.0320856005517731,"SUPT20H","SPT20 homolog, SAGA complex component",TRUE
+"214027_x_at",0.985498770484702,0.929430270980643,0.0895743223592062,-5.93577625635453,0.0317029763775132,"SUPT20H///DES","SPT20 homolog, SAGA complex component///desmin",TRUE
+"206506_s_at",0.52768025492085,0.0402745259036984,2.17862142478449,-3.85960836158498,1.17975855623405,"SUPT3H","SPT3 homolog, SAGA and STAGA complex component",TRUE
+"211106_at",0.643688366500038,0.114656080506337,1.64225301234455,-4.70507724421388,1.32686718878406,"SUPT3H","SPT3 homolog, SAGA and STAGA complex component",TRUE
+"201484_at",0.757479140651,0.253597630887402,-1.17212179484923,-5.29179894445675,-0.57191568114324,"SUPT4H1","SPT4 homolog, DSIF elongation factor subunit",TRUE
+"201483_s_at",0.805746717966166,0.345884016564221,-0.963115399314885,-5.4977131603868,-0.458230370024708,"SUPT4H1","SPT4 homolog, DSIF elongation factor subunit",TRUE
+"201480_s_at",0.807944276806637,0.34934558350546,0.956084900408189,-5.50400507389839,0.257836654685914,"SUPT5H","SPT5 homolog, DSIF elongation factor subunit",TRUE
+"208831_x_at",0.597654932724127,0.0749051414439984,-1.86896221288442,-4.36805133782632,-0.669049496302879,"SUPT6H","SPT6 homolog, histone chaperone",TRUE
+"208420_x_at",0.864079461576774,0.491224478568614,-0.699980348711789,-5.70381288273426,-0.256912403002003,"SUPT6H","SPT6 homolog, histone chaperone",TRUE
+"208830_s_at",0.894113242104072,0.570302792960904,-0.576176793115514,-5.77926922875615,-0.151529741744232,"SUPT6H","SPT6 homolog, histone chaperone",TRUE
+"1554311_a_at",0.993753494258002,0.970467994555163,0.0374418664718877,-5.93900069324583,0.0187078091915307,"SUPT6H","SPT6 homolog, histone chaperone",TRUE
+"201837_s_at",0.722362743674536,0.198911900988914,1.32427174791499,-5.11981640315541,0.47391082717273,"SUPT7L","SPT7-like STAGA complex gamma subunit",TRUE
+"201836_s_at",0.826140850652187,0.394180176026045,0.868968502722731,-5.57844298741493,0.329986793239449,"SUPT7L","SPT7-like STAGA complex gamma subunit",TRUE
+"201838_s_at",0.912722788750542,0.634318909795872,0.482306203057386,-5.82701394318878,0.15352566807482,"SUPT7L","SPT7-like STAGA complex gamma subunit",TRUE
+"212894_at",0.900867933475689,0.596867694982967,0.53663470578116,-5.80038564671352,0.131493139783684,"SUPV3L1","Suv3 like RNA helicase",TRUE
+"204295_at",0.201203203991061,0.00225733909087767,-3.45133409083375,-1.37368360051434,-1.35093053569633,"SURF1","surfeit 1",TRUE
+"217646_at",0.894729774938685,0.571700727481635,-0.574073219092454,-5.78042923296109,-0.466784020446589,"SURF1","surfeit 1",TRUE
+"205224_at",0.615637099066718,0.0861063366466028,-1.79623636717157,-4.47963738072424,-1.43146150250198,"SURF2","surfeit 2",TRUE
+"222977_at",0.741186481976394,0.231533694958189,-1.23017423495954,-5.22830926030219,-0.336999209481883,"SURF4","surfeit 4",TRUE
+"222978_at",0.819018525257656,0.375040742083487,-0.905310049882765,-5.54818788005709,-0.251011840237016,"SURF4","surfeit 4",TRUE
+"222979_s_at",0.8920930097751,0.564017744259404,-0.585667070573908,-5.77398480734673,-0.159568543459898,"SURF4","surfeit 4",TRUE
+"225038_s_at",0.579042978161571,0.0620094035567278,-1.96553423740406,-4.21509011147718,-0.532426261191167,"SURF6","surfeit 6",TRUE
+"226264_at",0.623667408398064,0.0949151960275396,1.74458314199138,-4.55693403224154,1.76982010949717,"SUSD1","sushi domain containing 1",TRUE
+"227480_at",0.9075549591285,0.616740468330504,-0.507613236908042,-5.81495466310304,-0.576012342875716,"SUSD2","sushi domain containing 2",TRUE
+"234310_s_at",0.985498770484702,0.930005053080246,0.0888427327691204,-5.93583980738253,0.118512322893137,"SUSD2","sushi domain containing 2",TRUE
+"243956_at",0.820536502908875,0.379869994483339,0.896027879743482,-5.55602460171338,0.248917398423369,"SUSD3","sushi domain containing 3",TRUE
+"227182_at",0.957017346544368,0.805462973914704,-0.249250684068478,-5.90946946317262,-0.397795543185224,"SUSD3","sushi domain containing 3",TRUE
+"223821_s_at",0.522667179791589,0.0383269128710947,-2.20251036575616,-3.81831458270604,-2.93818548578952,"SUSD4","sushi domain containing 4",TRUE
+"223822_at",0.607225105608561,0.0809078169978668,-1.8288992523686,-4.42991416796683,-1.93742151002345,"SUSD4","sushi domain containing 4",TRUE
+"219389_at",0.976371465776674,0.887120961279275,-0.14359156093431,-5.92964593887904,-0.17769829088635,"SUSD4","sushi domain containing 4",TRUE
+"214954_at",0.769258076576208,0.276012253573048,1.11687761384605,-5.34971754323022,1.55040801596119,"SUSD5","sushi domain containing 5",TRUE
+"202181_at",0.869990549756968,0.508150858829241,-0.672608676502139,-5.72170498264289,-0.285591552212269,"SUSD6","sushi domain containing 6",TRUE
+"218619_s_at",0.861357981297227,0.481696946612261,-0.71562521787728,-5.69328063183296,-0.213998775793661,"SUV39H1","suppressor of variegation 3-9 homolog 1",TRUE
+"1554572_a_at",0.89316156038085,0.567226584457016,0.580815067403551,-5.77669696266081,0.187706348437919,"SUV39H2","suppressor of variegation 3-9 homolog 2",TRUE
+"219262_at",0.951810226174863,0.779125902705059,0.283896294460376,-5.90050366564259,0.100433890581126,"SUV39H2","suppressor of variegation 3-9 homolog 2",TRUE
+"1566191_at",0.832605695407954,0.408858774414676,0.841864799713795,-5.6002569050074,0.780143387926291,"SUZ12","SUZ12 polycomb repressive complex 2 subunit",TRUE
+"212287_at",0.84571977676742,0.443589549892994,0.780094370688305,-5.64755117135226,0.274220241691419,"SUZ12","SUZ12 polycomb repressive complex 2 subunit",TRUE
+"1566190_at",0.97897951922649,0.898158407868475,-0.129464256163243,-5.93152311462336,-0.0661483253993014,"SUZ12","SUZ12 polycomb repressive complex 2 subunit",TRUE
+"236386_at",0.899808883319249,0.592639448715789,-0.542869262005665,-5.79715303240524,-0.528750524598546,"SUZ12P1","SUZ12 polycomb repressive complex 2 subunit pseudogene 1",TRUE
+"213971_s_at",0.952374805858222,0.78201125180869,0.280084132382679,-5.90154684465828,0.102122553195288,"SUZ12P1///SUZ12","SUZ12 polycomb repressive complex 2 subunit pseudogene 1///SUZ12 polycomb repressive complex 2 subunit",TRUE
+"203069_at",0.42796179417767,0.0185522813184568,2.5411735311676,-3.20536553515697,2.44530023424633,"SV2A","synaptic vesicle glycoprotein 2A",TRUE
+"232426_at",0.703902004301726,0.175407750184424,1.39984030282745,-5.02782616001739,0.654139345747105,"SV2B","synaptic vesicle glycoprotein 2B",TRUE
+"244717_x_at",0.809083788159815,0.352223362154182,0.950275992518106,-5.50917189512368,1.00017498346188,"SV2B","synaptic vesicle glycoprotein 2B",TRUE
+"205551_at",0.959395397489393,0.816473433955483,-0.234861135179145,-5.91285285349006,-0.0827398110594246,"SV2B","synaptic vesicle glycoprotein 2B",TRUE
+"1562372_at",0.724970327905974,0.202698549181323,1.31276259046951,-5.13345060868064,1.2625629776404,"SV2C","synaptic vesicle glycoprotein 2C",TRUE
+"216086_at",0.835087155533826,0.413984569853751,0.832546715150641,-5.60760738258858,0.666058140510792,"SV2C","synaptic vesicle glycoprotein 2C",TRUE
+"243139_at",0.843317145101463,0.437807436108035,0.790164429578169,-5.64007205404327,0.625655121986746,"SV2C","synaptic vesicle glycoprotein 2C",TRUE
+"242530_at",0.867834927246481,0.500825474419937,0.684390094513128,-5.71408738711167,0.42381533645181,"SV2C","synaptic vesicle glycoprotein 2C",TRUE
+"226723_at",0.871451481476429,0.512666683315459,0.66539333272892,-5.72630773886146,0.230223061325709,"SVBP","small vasohibin binding protein",TRUE
+"1553129_at",0.650679328571255,0.120674684804984,1.61402499299277,-4.74474063306086,1.25775680472715,"SVEP1","sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1",TRUE
+"213247_at",0.67368843181164,0.140222058735633,1.52978774033044,-4.8599061307387,1.2392088397921,"SVEP1","sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1",TRUE
+"236927_at",0.819018525257656,0.375121074594658,0.905155002385791,-5.5483193959603,0.205943712128766,"SVEP1","sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1",TRUE
+"224543_at",0.896118635245982,0.578416511320822,0.564003638895575,-5.78592509425921,0.252545629698585,"SVEP1","sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1",TRUE
+"1566721_at",0.945498722604777,0.754279498062022,0.316908842837171,-5.89088517543096,0.19528257375118,"SVEP1","sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1",TRUE
+"219552_at",0.953564723226096,0.786208954791279,0.274545613929564,-5.90303749125037,0.243781236301301,"SVEP1","sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1",TRUE
+"1566722_a_at",0.95442332217412,0.790572364879393,0.268797739580935,-5.90455322940093,0.200614260243812,"SVEP1","sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1",TRUE
+"202565_s_at",0.433660982257499,0.0195840930567914,2.51653447634354,-3.25156102325782,1.34935679263131,"SVIL","supervillin",TRUE
+"1569512_at",0.568543610339737,0.0579930080450793,1.99924645610763,-4.1604547192,1.07520981439781,"SVIL","supervillin",TRUE
+"202566_s_at",0.603702127972549,0.078334870462972,1.84574379571714,-4.40402016656164,1.17559513874637,"SVIL","supervillin",TRUE
+"217634_at",0.96351240321323,0.833799737737837,0.212318413027656,-5.9177509297056,0.136004385042919,"SVIL","supervillin",TRUE
+"230736_at",0.596382916302699,0.0728802169667695,1.88310950019182,-4.34597934553855,0.826729197039071,"SVIL-AS1","SVIL antisense RNA 1",TRUE
+"228786_at",0.929088231432081,0.687532968546534,0.407525220195565,-5.85911572842701,0.153983603294225,"SVIL-AS1///PTCHD3P1","SVIL antisense RNA 1///patched domain containing 3 pseudogene 1",TRUE
+"230737_s_at",0.991367768700244,0.959754688230706,0.05103531505899,-5.93841495409525,0.0225620114131138,"SVIL-AS1///PTCHD3P1","SVIL antisense RNA 1///patched domain containing 3 pseudogene 1",TRUE
+"230006_s_at",0.893605624314683,0.568949344088129,-0.578215930650876,-5.77814083584443,-0.351385305332279,"SVIP","small VCP interacting protein",TRUE
+"230005_at",0.901781358899845,0.598966072648554,-0.533548631458407,-5.80197233787083,-0.352020652986303,"SVIP","small VCP interacting protein",TRUE
+"226278_at",0.902024395176837,0.600425712630376,0.531405035497756,-5.80306921817867,0.316307856491456,"SVIP","small VCP interacting protein",TRUE
+"230285_at",0.920353677062947,0.660971330289048,-0.444529921569409,-5.84389210168562,-0.260405078416603,"SVIP","small VCP interacting protein",TRUE
+"229818_at",0.571677937624457,0.0595819878014163,-1.98566896948111,-4.18253431560414,-0.782851360006649,"SVOP","SV2 related protein",TRUE
+"1568625_at",0.95168059103032,0.778443685811552,-0.284798274825832,-5.90025479604731,-0.19261585548243,"SVOP","SV2 related protein",TRUE
+"1554300_a_at",0.803903145379763,0.342463457762032,0.970109836547443,-5.49141172519243,1.06070283346882,"SVOPL","SVOP like",TRUE
+"210369_at",0.69410086222651,0.163456549470763,-1.44140084292456,-4.97543848451753,-0.60007984768104,"SWAP70","SWAP switching B-cell complex 70kDa subunit",TRUE
+"209307_at",0.729041056651108,0.210545190389044,1.28943576053418,-5.1607753052543,0.668145839656681,"SWAP70","SWAP switching B-cell complex 70kDa subunit",TRUE
+"209306_s_at",0.835289077598304,0.414520320850019,0.83157701221497,-5.60836792954694,0.433339293457587,"SWAP70","SWAP switching B-cell complex 70kDa subunit",TRUE
+"226027_at",0.954449231029359,0.790836055415614,-0.268450681022286,-5.90464373073772,-0.075772080662583,"SWI5","SWI5 homologous recombination repair protein",TRUE
+"227352_at",0.999188340279058,0.997425570187676,-0.00326317505224877,-5.93967829435054,-0.0014922919499103,"SWSAP1","SWIM-type zinc finger 7 associated protein 1",TRUE
+"223548_at",0.360736459722853,0.0103530809619768,2.80165508657097,-2.70384594794111,0.923584019691813,"SWT1","SWT1, RNA endoribonuclease homolog",TRUE
+"225154_at",0.384135218769668,0.0123167456349098,-2.72498969390247,-2.85380613586987,-0.990965276426964,"SYAP1","synapse associated protein 1",TRUE
+"218692_at",0.923392984964514,0.671264433397848,-0.430117867630674,-5.84997563686603,-0.369534228753167,"SYBU","syntabulin",TRUE
+"1554675_a_at",0.820288124919738,0.378744283890141,0.898184599697969,-5.55421039253174,0.817905831062319,"SYCE1","synaptonemal complex central element protein 1",TRUE
+"233084_s_at",0.937623890519979,0.72378790592856,0.357923392804298,-5.87747813574505,0.446266621605274,"SYCE1","synaptonemal complex central element protein 1",TRUE
+"215301_at",0.51531387545335,0.0354971699838546,2.23926294034323,-3.75425003032665,2.00503302080467,"SYCE1L","synaptonemal complex central element protein 1 like",TRUE
+"1559960_x_at",0.671298718565642,0.137264935096006,1.54188046948467,-4.84367240418239,1.63962142698657,"SYCE1L","synaptonemal complex central element protein 1 like",TRUE
+"237304_at",0.725168361556674,0.203581846653212,-1.31010201958252,-5.136588119581,-0.980332105763766,"SYCE2","synaptonemal complex central element protein 2",TRUE
+"239854_at",0.967658787513338,0.8478938672554,0.194064164160613,-5.92135687459203,0.144114109984127,"SYCE3","synaptonemal complex central element protein 3",TRUE
+"229995_at",0.968852422299823,0.852944535802098,0.187539420197464,-5.9225674712846,0.0743748860425999,"SYCN","syncollin",TRUE
+"206740_x_at",0.62986301194198,0.100871245892758,1.71194016051166,-4.60492163169616,0.667900135580833,"SYCP1","synaptonemal complex protein 1",TRUE
+"216917_s_at",0.920119557710459,0.659781729057415,0.44620168528755,-5.84317369166653,0.378719864939292,"SYCP1","synaptonemal complex protein 1",TRUE
+"206546_at",0.594972224548427,0.071623622656473,-1.89206253379098,-4.33195079735214,-2.59863030481442,"SYCP2","synaptonemal complex protein 2",TRUE
+"237920_at",0.944850801239076,0.752091466631865,-0.319832747202315,-5.88998278513784,-0.390700441993434,"SYCP2","synaptonemal complex protein 2",TRUE
+"236337_at",0.304824368772306,0.00603237251050086,3.03612184736546,-2.23473116813831,3.11330742074761,"SYCP2L","synaptonemal complex protein 2 like",TRUE
+"1553599_a_at",0.660460734341314,0.128459380240349,-1.57920972449006,-4.79292479179389,-1.13334928855612,"SYCP3","synaptonemal complex protein 3",TRUE
+"241861_at",0.919372089675945,0.657035978310637,-0.45006527489547,-5.84150326426375,-0.368430753641304,"SYCP3","synaptonemal complex protein 3",TRUE
+"216271_x_at",0.808811461484454,0.352016050068296,0.950693383264384,-5.5088016022332,0.695068384893896,"SYDE1","synapse defective Rho GTPase homolog 1",TRUE
+"44702_at",0.868397087637799,0.503628619470837,0.67987039166722,-5.71702467992152,0.484765689099577,"SYDE1","synapse defective Rho GTPase homolog 1",TRUE
+"216272_x_at",0.888750194607196,0.55527341517521,0.598961960392866,-5.76644150216505,0.638626793742853,"SYDE1","synapse defective Rho GTPase homolog 1",TRUE
+"212962_at",0.972112264314695,0.86625844588433,0.17037881689947,-5.92555443645835,0.184525968824823,"SYDE1","synapse defective Rho GTPase homolog 1",TRUE
+"1560101_at",0.784925710185113,0.309835643656496,-1.03938536500873,-5.42676639356922,-0.564858859706883,"SYDE2","synapse defective Rho GTPase homolog 2",TRUE
+"1559979_at",0.851319596585235,0.45486556224911,0.760683841614818,-5.66171208261257,0.457530881642463,"SYF2","SYF2 pre-mRNA splicing factor",TRUE
+"202553_s_at",0.885312914741353,0.546819892469066,-0.611919035642029,-5.75893255772899,-0.152562756200105,"SYF2","SYF2 pre-mRNA splicing factor",TRUE
+"226068_at",0.714590421965913,0.190015157525549,1.35200281102108,-5.08655431048323,1.68117631847298,"SYK","spleen associated tyrosine kinase",TRUE
+"244023_at",0.748440891167983,0.241390154089734,1.20374865687559,-5.25754040142608,1.18890717300627,"SYK","spleen associated tyrosine kinase",TRUE
+"207540_s_at",0.806325320300355,0.347209394460242,0.96041790795185,-5.50013225254795,1.37475309507805,"SYK","spleen associated tyrosine kinase",TRUE
+"209269_s_at",0.828426831961877,0.398313692129659,0.861271393761047,-5.58470329599583,1.07634991617045,"SYK","spleen associated tyrosine kinase",TRUE
+"1559587_at",0.637485146909712,0.108847386849918,1.67070379612205,-4.66456853019947,0.831822858092105,"SYMPK","symplekin",TRUE
+"32402_s_at",0.793444243545258,0.325170647738794,-1.00622477885995,-5.45821478868121,-0.279273174930262,"SYMPK","symplekin",TRUE
+"202339_at",0.928576500287959,0.685999519513482,-0.40964540149874,-5.85827860640207,-0.170617523694531,"SYMPK","symplekin",TRUE
+"1554595_at",0.950358151876194,0.774462297713798,0.290067035688073,-5.89878541874793,0.104612145789464,"SYMPK","symplekin",TRUE
+"221914_at",0.8520829211781,0.457576710538824,0.756060343366229,-5.66503541474257,0.582707467595409,"SYN1","synapsin I",TRUE
+"1553264_a_at",0.965914344760007,0.84036253439065,0.203809699804049,-5.91947188848086,0.119498987801851,"SYN1","synapsin I",TRUE
+"229039_at",0.560723146946816,0.0543955294267199,2.03125080518228,-4.10801244805295,0.894682741283734,"SYN2","synapsin II",TRUE
+"1553037_a_at",0.813021318305036,0.362169300061177,-0.930443023810781,-5.52659491108595,-0.781984566498271,"SYN2","synapsin II",TRUE
+"210315_at",0.8920930097751,0.563441096746855,0.58654050702527,-5.77349425848882,0.359395936748434,"SYN2","synapsin II",TRUE
+"240197_at",0.899119611740895,0.589365299774704,0.547711983620963,-5.79461704283345,0.305255825731152,"SYN2","synapsin II",TRUE
+"210247_at",0.962351204352784,0.828458746236626,0.21925487058696,-5.91629612884591,0.065900442393243,"SYN2","synapsin II",TRUE
+"206322_at",0.879960488971225,0.535049202734693,0.630138656890921,-5.74811182132505,0.302480396401335,"SYN3","synapsin III",TRUE
+"221276_s_at",0.926209999527899,0.679515268073512,0.418631966005612,-5.85468295843951,0.204112237403386,"SYNC","syncoilin, intermediate filament protein",TRUE
+"217833_at",0.631255973326775,0.102240125060353,1.70467080088217,-4.6155159262844,0.52615918437666,"SYNCRIP","synaptotagmin binding cytoplasmic RNA interacting protein",TRUE
+"236146_at",0.70573152022539,0.178106957949625,1.39076862909387,-5.03909320980589,0.484113578799046,"SYNCRIP","synaptotagmin binding cytoplasmic RNA interacting protein",TRUE
+"209024_s_at",0.734572849833594,0.218873823441044,1.26540016195139,-5.18849390421441,0.458579618371598,"SYNCRIP","synaptotagmin binding cytoplasmic RNA interacting protein",TRUE
+"217834_s_at",0.75987662331021,0.257670097780911,1.16182380425441,-5.30278175208908,0.417303154132489,"SYNCRIP","synaptotagmin binding cytoplasmic RNA interacting protein",TRUE
+"1555427_s_at",0.838303520227789,0.423174106380774,0.81602196994547,-5.62045445704557,0.464761092021432,"SYNCRIP","synaptotagmin binding cytoplasmic RNA interacting protein",TRUE
+"217832_at",0.871451481476429,0.512307075756084,0.665966606636073,-5.7259437792749,0.217231048404644,"SYNCRIP","synaptotagmin binding cytoplasmic RNA interacting protein",TRUE
+"209025_s_at",0.871744769522775,0.514341372108554,0.662726546468845,-5.7279968771983,0.322422372684386,"SYNCRIP","synaptotagmin binding cytoplasmic RNA interacting protein",TRUE
+"219310_at",0.891653456393983,0.561598872011937,0.589333980902031,-5.77192061057878,0.294275950966854,"SYNDIG1","synapse differentiation inducing 1",TRUE
+"237053_at",0.942502815705589,0.742454417107157,-0.332745218578875,-5.88589956673066,-0.199348585383761,"SYNDIG1L","synapse differentiation inducing 1 like",TRUE
+"244070_at",0.528056136690037,0.0405943846083628,2.17479862636348,-3.86619055586965,1.78932066690358,"SYNE1","spectrin repeat containing nuclear envelope protein 1",TRUE
+"232027_at",0.722160153958635,0.198374332541809,1.32591946469327,-5.11785624159881,0.974683220753763,"SYNE1","spectrin repeat containing nuclear envelope protein 1",TRUE
+"215350_at",0.774230543658252,0.287113515294064,1.09072588205461,-5.376271930043,0.982066473564989,"SYNE1","spectrin repeat containing nuclear envelope protein 1",TRUE
+"209447_at",0.936992192746977,0.717732065575265,-0.366141879836191,-5.87459796314121,-0.43797627080991,"SYNE1","spectrin repeat containing nuclear envelope protein 1",TRUE
+"244144_at",0.956312775124107,0.801903462297484,-0.253913982198831,-5.90833009171755,-0.15707179504031,"SYNE1","spectrin repeat containing nuclear envelope protein 1",TRUE
+"1558392_at",0.731557732513697,0.215272654017611,1.27570477716994,-5.17666478382613,0.796554588448412,"SYNE2","spectrin repeat containing nuclear envelope protein 2",TRUE
+"243841_at",0.839519981963042,0.426728978040752,0.809689946496808,-5.62531327350783,0.331187416993407,"SYNE2","spectrin repeat containing nuclear envelope protein 2",TRUE
+"242774_at",0.929088231432081,0.687595212497238,0.407439200488269,-5.85914960179399,0.16259360972035,"SYNE2","spectrin repeat containing nuclear envelope protein 2",TRUE
+"240777_at",0.95930712748485,0.815555809780536,-0.236058399231384,-5.91257897197007,-0.0994625622703613,"SYNE2","spectrin repeat containing nuclear envelope protein 2",TRUE
+"202761_s_at",0.998038817582822,0.990838271558692,0.011613045498968,-5.93961779425248,0.00434278828672063,"SYNE2","spectrin repeat containing nuclear envelope protein 2",TRUE
+"1553644_at",0.465776708318531,0.0241166116719383,2.42090403693651,-3.42860551810809,0.770713321735902,"SYNE3","spectrin repeat containing nuclear envelope family member 3",TRUE
+"219563_at",0.899808883319249,0.593080817788743,0.542217448473801,-5.79749269650791,0.440756357047457,"SYNE3///LINC00341","spectrin repeat containing nuclear envelope family member 3///long intergenic non-protein coding RNA 341",TRUE
+"235515_at",0.296090407530139,0.00535589232825437,-3.08705707310821,-2.13096645514544,-2.19450320357444,"SYNE4","spectrin repeat containing nuclear envelope family member 4",TRUE
+"230297_x_at",0.740610299769501,0.230640506757514,-1.23261072247509,-5.2255864790149,-0.433945279174064,"SYNGAP1","synaptic Ras GTPase activating protein 1",TRUE
+"234285_at",0.835289077598304,0.414414700124535,-0.831768121736961,-5.60821810616896,-0.244333988611324,"SYNGAP1","synaptic Ras GTPase activating protein 1",TRUE
+"204287_at",0.658590024406624,0.126766024554483,-1.58663026945292,-4.78272345810797,-0.971983140812778,"SYNGR1","synaptogyrin 1",TRUE
+"210613_s_at",0.849303815076661,0.450183639154764,0.768707492238673,-5.65589929621492,0.50082009981752,"SYNGR1","synaptogyrin 1",TRUE
+"213854_at",0.959120911159536,0.814542428753273,0.237381011501197,-5.91227480600993,0.110165830090184,"SYNGR1","synaptogyrin 1",TRUE
+"201079_at",0.888750194607196,0.55529273254711,-0.598932470770807,-5.76645841515018,-0.350870765094378,"SYNGR2","synaptogyrin 2",TRUE
+"243103_at",0.954577684533304,0.792243842066152,0.266598379253455,-5.9051247857256,0.142541526032906,"SYNGR2","synaptogyrin 2",TRUE
+"205691_at",0.943824539742785,0.748269934382045,-0.324946375289641,-5.88838486754159,-0.426736587877238,"SYNGR3","synaptogyrin 3",TRUE
+"206719_at",0.970353888480813,0.858883821537572,-0.179877331517223,-5.92393641355132,-0.0900100507204238,"SYNGR4","synaptogyrin 4",TRUE
+"212990_at",0.827768017240356,0.39664486230214,-0.864372724895907,-5.58218711448569,-0.318772788465646,"SYNJ1","synaptojanin 1",TRUE
+"207594_s_at",0.939142373216553,0.727438125390416,-0.352981759779418,-5.8791788430833,-0.117054636514664,"SYNJ1","synaptojanin 1",TRUE
+"232993_at",0.988065316951061,0.942898059885347,-0.0724446344954015,-5.93712758707674,-0.0643897141690308,"SYNJ1","synaptojanin 1",TRUE
+"240257_at",0.644755894025997,0.114988838091404,1.6406602404722,-4.7073293303066,0.612623208921756,"SYNJ2","synaptojanin 2",TRUE
+"1555009_a_at",0.657571067962164,0.126345186572524,1.58848722556405,-4.78016478090262,0.697638882946771,"SYNJ2","synaptojanin 2",TRUE
+"210612_s_at",0.69794616906853,0.168911984772718,1.42213735951073,-4.99987675597726,1.0791491212771,"SYNJ2","synaptojanin 2",TRUE
+"212828_at",0.723649742218726,0.200184758117132,1.32038409717983,-5.12443309880653,0.591606873973411,"SYNJ2","synaptojanin 2",TRUE
+"216180_s_at",0.725225714005638,0.203995524963917,1.30885907072998,-5.13805203739091,0.630465875222344,"SYNJ2","synaptojanin 2",TRUE
+"216182_at",0.8794780023158,0.533992340976271,0.631785019151378,-5.74711898012824,0.245740382114382,"SYNJ2","synaptojanin 2",TRUE
+"216181_at",0.952697366942815,0.783527639253584,0.278082362534956,-5.90208901460824,0.0876205383832556,"SYNJ2","synaptojanin 2",TRUE
+"217645_at",0.695739345331756,0.165195942955589,-1.43520353262794,-4.98332992698111,-0.525320351805457,"SYNJ2BP-COX16///COX16","SYNJ2BP-COX16 readthrough///COX16, cytochrome c oxidase assembly homolog",TRUE
+"227274_at",0.737123149977386,0.222750296983663,-1.25445219181833,-5.20097158550396,-0.455921666560167,"SYNJ2BP-COX16///SYNJ2BP","SYNJ2BP-COX16 readthrough///synaptojanin 2 binding protein",TRUE
+"219156_at",0.869698482173109,0.507296277886873,-0.673978151967209,-5.7208260113265,-0.238024692469139,"SYNJ2BP-COX16///SYNJ2BP","SYNJ2BP-COX16 readthrough///synaptojanin 2 binding protein",TRUE
+"235722_at",0.947778780715578,0.761844271500124,-0.306821408094334,-5.89393539120458,-0.141240476078096,"SYNJ2BP-COX16///SYNJ2BP","SYNJ2BP-COX16 readthrough///synaptojanin 2 binding protein",TRUE
+"212730_at",0.906476756086155,0.613354601876007,-0.512526046166984,-5.81254387914663,-0.406902057244451,"SYNM","synemin",TRUE
+"235128_at",0.871451481476429,0.51284270618003,-0.665112804851983,-5.72648573069862,-0.47643149793369,"SYNPO","synaptopodin",TRUE
+"235914_at",0.893914276642775,0.569946068761507,0.576714002369337,-5.77897232902205,0.502917353355211,"SYNPO","synaptopodin",TRUE
+"202796_at",0.923124080520773,0.670555583258745,0.431107377486798,-5.84956424486407,0.27683104067169,"SYNPO","synaptopodin",TRUE
+"225894_at",0.824399995824329,0.391795868367175,-0.873432123911956,-5.574788864353,-0.60945634690514,"SYNPO2","synaptopodin 2",TRUE
+"225720_at",0.890944566293907,0.560096689311719,-0.591615335863599,-5.77063009146806,-0.60508126961743,"SYNPO2","synaptopodin 2",TRUE
+"227662_at",0.923050713409153,0.670235887566062,-0.431553795537331,-5.84937834112816,-0.591143721765683,"SYNPO2","synaptopodin 2",TRUE
+"225895_at",0.923935703779429,0.672939979640534,-0.427780643396203,-5.85094365821571,-0.405971747267568,"SYNPO2","synaptopodin 2",TRUE
+"232119_at",0.937623890519979,0.723491452745389,-0.358325125736218,-5.87733884924147,-0.190776919101169,"SYNPO2","synaptopodin 2",TRUE
+"225721_at",0.942502815705589,0.742391111259071,-0.332830229293217,-5.8858721545612,-0.0925702207812709,"SYNPO2","synaptopodin 2",TRUE
+"244108_at",0.955892698633978,0.799482116082043,-0.257089460853376,-5.9075422234434,-0.188193870512773,"SYNPO2","synaptopodin 2",TRUE
+"243313_at",0.738061563377262,0.224857967048213,-1.24856076678378,-5.20764770315769,-1.11815738121535,"SYNPO2L","synaptopodin 2 like",TRUE
+"219804_at",0.953983577550391,0.787804537595789,-0.272442683926141,-5.90359573623012,-0.267807706677709,"SYNPO2L","synaptopodin 2 like",TRUE
+"230303_at",0.905462783815257,0.611725170970676,0.514894864840127,-5.81137337740294,0.323634323225129,"SYNPR","synaptoporin",TRUE
+"240184_at",0.849935057946582,0.452129215364885,-0.765367167750955,-5.6583262185922,-0.371857716717963,"SYNPR-AS1","SYNPR antisense RNA 1",TRUE
+"222715_s_at",0.863399554037892,0.487720077301514,-0.705714273486719,-5.69997850996332,-0.341828713274101,"SYNRG","synergin, gamma",TRUE
+"64418_at",0.870433264908839,0.508751211520519,-0.67164737684342,-5.72232095196283,-0.324655156694854,"SYNRG","synergin, gamma",TRUE
+"221937_at",0.87106619978761,0.5115031321818,-0.667249037554688,-5.7251285036098,-0.384313472085056,"SYNRG","synergin, gamma",TRUE
+"1553165_at",0.896118635245982,0.578339924560532,0.564118138881266,-5.7858631314342,0.462819970296767,"SYNRG","synergin, gamma",TRUE
+"232981_s_at",0.908375053779996,0.619259995670913,-0.503965667327718,-5.81672992467944,-0.175293829992968,"SYNRG","synergin, gamma",TRUE
+"232387_at",0.93280832378428,0.703201841452522,0.385967617101827,-5.86738452577199,0.29660636683938,"SYNRG","synergin, gamma",TRUE
+"213200_at",0.984304383572197,0.923713684996133,-0.0968532560238373,-5.93511559173053,-0.0649021317979717,"SYP","synaptophysin",TRUE
+"201259_s_at",0.725836505745628,0.204840791835116,1.30632544062145,-5.14103244989928,0.576145991540747,"SYPL1","synaptophysin like 1",TRUE
+"201260_s_at",0.789795896476304,0.318266737252502,1.02101519602863,-5.44430187078896,0.3195594155008,"SYPL1","synaptophysin like 1",TRUE
+"230611_at",0.919485127002411,0.657946941366451,-0.448782675724882,-5.84205936368661,-0.123037947479599,"SYPL2","synaptophysin like 2",TRUE
+"238470_at",0.755685495730197,0.249908000299317,1.18155849674373,-5.28166028778173,0.428277181006502,"SYS1","Sys1 golgi trafficking protein",TRUE
+"224669_at",0.829459856894727,0.400738638536167,0.856779776483313,-5.58833252227791,0.25910689434957,"SYS1","Sys1 golgi trafficking protein",TRUE
+"224670_at",0.955552865298326,0.796390177703048,-0.261148324344376,-5.90652101306702,-0.104665590549461,"SYS1","Sys1 golgi trafficking protein",TRUE
+"224668_at",0.99679212827105,0.983764722079469,-0.0205802325445882,-5.9394771892279,-0.0153436398847049,"SYS1","Sys1 golgi trafficking protein",TRUE
+"218094_s_at",0.567293479905907,0.0575008603892758,2.00351873460572,-4.15348630582967,1.59485304339584,"SYS1-DBNDD2///SYS1///DBNDD2","SYS1-DBNDD2 readthrough (NMD candidate)///Sys1 golgi trafficking protein///dysbindin domain containing 2",TRUE
+"203998_s_at",0.931370027472813,0.695567240012766,0.396447586816361,-5.86342002268244,0.557674701106093,"SYT1","synaptotagmin 1",TRUE
+"203999_at",0.932830928398943,0.703369998188775,-0.385737288314568,-5.86747048213891,-0.426654335878073,"SYT1","synaptotagmin 1",TRUE
+"232677_at",0.643515428391208,0.113877784118129,1.64599362575523,-4.69978165233078,1.10577708870184,"SYT11","synaptotagmin 11",TRUE
+"209198_s_at",0.708894565317004,0.181266234584261,1.38028856708757,-5.05203394981734,0.747567287487287,"SYT11","synaptotagmin 11",TRUE
+"209197_at",0.892895911526563,0.566499642288719,-0.581913020941547,-5.77608514397571,-0.304943220942927,"SYT11","synaptotagmin 11",TRUE
+"215865_at",0.627053909308516,0.0978112730161464,1.72849885258797,-4.58066343099866,0.848559513149524,"SYT12","synaptotagmin 12",TRUE
+"215860_at",0.670164229230396,0.136040688012839,-1.54694973866052,-4.83683712028489,-0.758009449895249,"SYT12","synaptotagmin 12",TRUE
+"228072_at",0.695005304830231,0.164571262954235,-1.43742314342436,-4.9805067425734,-1.79742754356917,"SYT12","synaptotagmin 12",TRUE
+"221859_at",0.736132227107113,0.221541073197554,1.2578515211692,-5.19710722732738,0.458433091043443,"SYT13","synaptotagmin 13",TRUE
+"226086_at",0.776074974591224,0.293554943017003,-1.07588497324565,-5.39109204071716,-0.715469483390253,"SYT13","synaptotagmin 13",TRUE
+"1553654_at",0.47660694009436,0.0264040680666816,2.37882414850488,-3.50532753937546,3.02723238021299,"SYT14","synaptotagmin 14",TRUE
+"1560879_a_at",0.765975788626919,0.266364840771168,1.14023437936566,-5.3255305201413,1.11514284146846,"SYT15","synaptotagmin 15",TRUE
+"1560878_at",0.831013183269159,0.40500181191672,0.8489253901254,-5.5946363708893,0.217141832438662,"SYT15","synaptotagmin 15",TRUE
+"239671_at",0.801587742916188,0.338942559959944,0.977359495307701,-5.48483644544918,1.08479009648268,"SYT16","synaptotagmin 16",TRUE
+"1554797_at",0.990797621966014,0.953412065217325,0.0590875536666255,-5.9379831213114,0.0413798476075709,"SYT16","synaptotagmin 16",TRUE
+"229053_at",0.806221445484273,0.346992112955504,-0.960859652016865,-5.49973652417877,-1.26184117734643,"SYT17","synaptotagmin 17",TRUE
+"205613_at",0.856148000488586,0.469568234059277,-0.735804357499852,-5.67936897742006,-0.891085644476476,"SYT17","synaptotagmin 17",TRUE
+"214903_at",0.89961817630669,0.590644085765639,0.545818989036503,-5.79561095315603,0.40783078317418,"SYT2","synaptotagmin 2",TRUE
+"223901_at",0.77204612088057,0.282365191295159,-1.10182036931699,-5.36507489161886,-0.801677869664107,"SYT3","synaptotagmin 3",TRUE
+"223529_at",0.637485146909712,0.108822940149208,1.67082621550684,-4.6643930830954,1.29260574398374,"SYT4","synaptotagmin 4",TRUE
+"206161_s_at",0.914966942918905,0.641861830535564,-0.47154508024662,-5.83195915003634,-0.400484989191996,"SYT5","synaptotagmin 5",TRUE
+"206162_x_at",0.92070400963176,0.66253402004944,0.442335804298225,-5.84483096848566,0.471892868235946,"SYT5","synaptotagmin 5",TRUE
+"244227_at",0.819018525257656,0.373050410968741,0.909158561027509,-5.54491679294205,0.26691963983945,"SYT6","synaptotagmin 6",TRUE
+"226167_at",0.648804835530704,0.119626914439598,-1.61885304805689,-4.73799429936312,-1.61896433267444,"SYT7","synaptotagmin 7",TRUE
+"232025_at",0.7768734672127,0.294779120022163,-1.07309100694826,-5.39386180819419,-0.881576164755532,"SYT7","synaptotagmin 7",TRUE
+"231025_at",0.843816788557882,0.439587514831599,-0.78705562530302,-5.64239063088047,-0.419785554421009,"SYT7","synaptotagmin 7",TRUE
+"1559392_s_at",0.942303845415102,0.740842571325427,-0.334910478167115,-5.88519920806156,-0.343363649464493,"SYT7","synaptotagmin 7",TRUE
+"1559956_at",0.975475861996229,0.883082579027861,0.14876779162601,-5.92890961542352,0.118256706983533,"SYT7","synaptotagmin 7",TRUE
+"232802_at",0.932091525948902,0.699995439984061,-0.390363597576587,-5.8657342974674,-0.240124655643744,"SYT8","synaptotagmin 8",TRUE
+"1555053_at",0.730791270702543,0.213389714435594,-1.28114565215396,-5.17038594379642,-0.647345413849489,"SYT9","synaptotagmin 9",TRUE
+"1563658_a_at",0.739367922105944,0.22714754270089,-1.24220845766999,-5.21481583190464,-1.14236499020867,"SYT9","synaptotagmin 9",TRUE
+"1555052_a_at",0.807528762746328,0.348862689758161,0.957062815845516,-5.50313241770369,0.471862789292332,"SYT9","synaptotagmin 9",TRUE
+"232445_at",0.895661101269965,0.575238035136622,0.568762008741216,-5.78333977765773,0.30673172319203,"SYT9","synaptotagmin 9",TRUE
+"227134_at",0.958933497686198,0.81415045377655,0.237892712872261,-5.91215667471543,0.189868962916096,"SYTL1","synaptotagmin like 1",TRUE
+"225496_s_at",0.612420348961838,0.0843046093255341,-1.80735878773075,-4.46277823401456,-1.96233219086868,"SYTL2","synaptotagmin like 2",TRUE
+"220613_s_at",0.747716708737985,0.239573163530544,-1.20855803421707,-5.25226136041631,-1.06419525121388,"SYTL2","synaptotagmin like 2",TRUE
+"232914_s_at",0.76469251347209,0.2647366529277,-1.1442372549417,-5.32134103842446,-1.25826701487297,"SYTL2","synaptotagmin like 2",TRUE
+"238423_at",0.479592271100631,0.0269063718860069,2.3700364602251,-3.5212551327409,1.9407158602751,"SYTL3","synaptotagmin like 3",TRUE
+"236864_at",0.534877314927003,0.0425553967980332,2.15194053799802,-3.90539809605196,1.65836330881641,"SYTL3","synaptotagmin like 3",TRUE
+"1562255_at",0.547343369043481,0.0479362197193812,2.09378056316485,-4.00397651347761,1.57078013063898,"SYTL3","synaptotagmin like 3",TRUE
+"1561882_at",0.633411263775153,0.104647266918955,-1.6920860947991,-4.6337766608008,-1.31822275640666,"SYTL3","synaptotagmin like 3",TRUE
+"229991_s_at",0.554642754132296,0.0511882957353176,2.06141569102682,-4.0580814787955,1.71638248611489,"SYTL4","synaptotagmin like 4",TRUE
+"1563513_at",0.923101832489914,0.670339920570271,0.431408515702711,-5.84943886136065,0.448146934450838,"SYTL4","synaptotagmin like 4",TRUE
+"227703_s_at",0.954096423385239,0.78931484030045,-0.270453306193227,-5.90411991464096,-0.268212735175279,"SYTL4","synaptotagmin like 4",TRUE
+"1553033_at",0.752913428584105,0.246036582083875,-1.19157265503092,-5.27082365006033,-1.71830109978253,"SYTL5","synaptotagmin like 5",TRUE
+"242093_at",0.774389765062463,0.290670809663912,-1.08250069681932,-5.38450796767691,-2.04512763304154,"SYTL5","synaptotagmin like 5",TRUE
+"212002_at",0.819018525257656,0.373100154489632,0.909062211518474,-5.54499884267519,0.230252767259472,"SZRD1","SUZ RNA binding domain containing 1",TRUE
+"212004_at",0.931582451098271,0.698217339001905,0.392804750043409,-5.86480994865372,0.116344096851241,"SZRD1","SUZ RNA binding domain containing 1",TRUE
+"212003_at",0.954449231029359,0.790996530061235,-0.268239487431478,-5.90469874617765,-0.115418522677475,"SZRD1","SUZ RNA binding domain containing 1",TRUE
+"212005_at",0.986280972175967,0.932830899866974,-0.0852466754689314,-5.93614461482306,-0.0280165774569454,"SZRD1","SUZ RNA binding domain containing 1",TRUE
+"231249_at",0.757479140651,0.253578688345043,-1.17216998081323,-5.29174735470706,-0.539740084722181,"SZT2","seizure threshold 2 homolog (mouse)",TRUE
+"215364_s_at",0.877857073443889,0.52900301675572,0.63958121236804,-5.74238363992033,0.209019965919842,"SZT2","seizure threshold 2 homolog (mouse)",TRUE
+"1569709_at",0.980009054680439,0.905760467766727,-0.119749897917908,-5.93270138964308,-0.077330787602861,"SZT2","seizure threshold 2 homolog (mouse)",TRUE
+"203900_at",0.980808506518944,0.909718196039424,0.114697208975598,-5.93327797685263,0.0369436400426855,"SZT2","seizure threshold 2 homolog (mouse)",TRUE
+"206524_at",0.693988314656736,0.16334964407722,1.44178346678471,-4.97495035477118,0.794801345832727,"T","T brachyury transcription factor",TRUE
+"1553930_at",0.700963156261921,0.172687705407986,1.40909530107213,-5.01626913757782,1.16372602002119,"TAAR1","trace amine associated receptor 1",TRUE
+"221394_at",0.85492369444809,0.467029920544592,0.740066163698218,-5.67638388381265,0.273908597305407,"TAAR2","trace amine associated receptor 2",TRUE
+"221393_at",0.970893641742918,0.86089744717825,0.177282138354574,-5.92438717832963,0.0938513802348133,"TAAR3","trace amine associated receptor 3 (gene/pseudogene)",TRUE
+"221459_at",0.777812682097981,0.296799377898677,1.06849824128284,-5.39840079731858,0.521194987580175,"TAAR5","trace amine associated receptor 5",TRUE
+"1553552_at",0.00436249027974301,9.57473861123295e-07,6.69438873987411,5.3766414051174,2.45132959891877,"TAAR8","trace amine associated receptor 8",TRUE
+"1553066_at",0.919156359329732,0.655721814840636,0.451916916543134,-5.84069769874937,0.291951658816701,"TAAR9","trace amine associated receptor 9 (gene/pseudogene)",TRUE
+"203901_at",0.676475496596199,0.143475516228644,-1.51672300275915,-4.87733045624112,-0.457184499340905,"TAB1","TGF-beta activated kinase 1 (MAP3K7) binding protein 1",TRUE
+"1561300_at",0.636147339487472,0.107601328051544,1.67697338130612,-4.65557064638116,1.23996840080754,"TAB2","TGF-beta activated kinase 1/MAP3K7 binding protein 2",TRUE
+"210284_s_at",0.951934441578502,0.780090890930029,0.282620863642217,-5.90085423870173,0.0796069133657458,"TAB2","TGF-beta activated kinase 1/MAP3K7 binding protein 2",TRUE
+"212184_s_at",0.99663007923251,0.983250536879393,-0.0212321269911071,-5.93946391350857,-0.0088832305132982,"TAB2","TGF-beta activated kinase 1/MAP3K7 binding protein 2",TRUE
+"1552928_s_at",0.776954388941225,0.295386328381873,1.07170824474998,-5.39523021192007,0.517324523049879,"TAB3","TGF-beta activated kinase 1/MAP3K7 binding protein 3",TRUE
+"1552927_at",0.859276375962637,0.476136783381255,0.724838518549381,-5.68697451961713,0.426947823439597,"TAB3","TGF-beta activated kinase 1/MAP3K7 binding protein 3",TRUE
+"227357_at",0.919372089675945,0.656956691511528,0.450176943755827,-5.84145477409334,0.208104752697997,"TAB3","TGF-beta activated kinase 1/MAP3K7 binding protein 3",TRUE
+"1558518_at",0.986342822130003,0.933655376700206,-0.0841976990611411,-5.93623115701635,-0.0720404464200373,"TAB3","TGF-beta activated kinase 1/MAP3K7 binding protein 3",TRUE
+"206552_s_at",0.790887605610217,0.320938246290754,1.01526564515824,-5.4497321343071,0.936528316330731,"TAC1","tachykinin precursor 1",TRUE
+"219992_at",0.942050821890073,0.739494818924555,0.336722223929255,-5.88460974128414,0.13280154752939,"TAC3","tachykinin 3",TRUE
+"200911_s_at",0.857004292924248,0.471630583809743,-0.732351704947603,-5.68177531921497,-0.361717253569104,"TACC1","transforming acidic coiled-coil containing protein 1",TRUE
+"217433_at",0.895213601869362,0.57328031282316,-0.571699445116038,-5.78173330141288,-0.244469345142473,"TACC1","transforming acidic coiled-coil containing protein 1",TRUE
+"1554690_a_at",0.9116561917482,0.630168158019652,-0.488252533275431,-5.82423454452821,-0.275108962049222,"TACC1","transforming acidic coiled-coil containing protein 1",TRUE
+"1557305_at",0.935318317015903,0.712398135200349,-0.373401972865986,-5.8719999745999,-0.283884417891072,"TACC1","transforming acidic coiled-coil containing protein 1",TRUE
+"217437_s_at",0.936143408699214,0.715069288560038,-0.369763695173583,-5.87330820687754,-0.236746381450748,"TACC1","transforming acidic coiled-coil containing protein 1",TRUE
+"242290_at",0.954449231029359,0.791015479692367,0.268214549482158,-5.90470523961709,0.106851839594592,"TACC1","transforming acidic coiled-coil containing protein 1",TRUE
+"1570025_at",0.892746695408886,0.565767924063791,-0.583018917843669,-5.77546776854985,-0.437466088333013,"TACC2","transforming acidic coiled-coil containing protein 2",TRUE
+"202289_s_at",0.910860516303107,0.627985677824061,0.491386297019096,-5.82275638731355,0.22133195003296,"TACC2","transforming acidic coiled-coil containing protein 2",TRUE
+"211382_s_at",0.924874199396311,0.675024468204063,0.424876360005471,-5.85213932052395,0.19272066031116,"TACC2","transforming acidic coiled-coil containing protein 2",TRUE
+"1570546_a_at",0.926385162475824,0.680043802124,-0.417898163682764,-5.85497943979104,-0.154258175061555,"TACC2","transforming acidic coiled-coil containing protein 2",TRUE
+"218308_at",0.852006864319744,0.457199914448967,-0.756701931781806,-5.66457539163955,-0.297108164569655,"TACC3","transforming acidic coiled-coil containing protein 3",TRUE
+"221069_s_at",0.734203380012717,0.218575521473023,-1.26624877222788,-5.18752284581775,-0.524762349058133,"TACO1","translational activator of cytochrome c oxidase I",TRUE
+"229680_at",0.897449856549225,0.584117980707101,0.555500956584641,-5.79049230738884,0.256704798578737,"TACO1","translational activator of cytochrome c oxidase I",TRUE
+"210637_at",0.838991915745708,0.4244059625355,0.813824009627021,-5.62214506328878,0.413927161460716,"TACR1","tachykinin receptor 1",TRUE
+"230908_at",0.840879524142924,0.430487499647557,-0.803030819786778,-5.63038475726349,-0.59221929052002,"TACR1","tachykinin receptor 1",TRUE
+"208049_s_at",0.899808883319249,0.593490911533629,0.541612035208198,-5.79780782583521,0.484327165171363,"TACR1","tachykinin receptor 1",TRUE
+"208048_at",0.969882914559333,0.856772960263158,0.182599201892958,-5.92345662989403,0.115402073557616,"TACR1","tachykinin receptor 1",TRUE
+"214348_at",0.976660494182006,0.888881625075278,0.141336080587691,-5.92995864342545,0.104299498171748,"TACR2","tachykinin receptor 2",TRUE
+"208183_at",0.863769633081355,0.489458353382067,0.70286714163315,-5.70188616293671,0.539041840488425,"TACR3","tachykinin receptor 3",TRUE
+"227128_s_at",0.623852759019384,0.0954906203935385,1.74135424611298,-4.56171074590587,0.573770894811837,"TACSTD2","tumor-associated calcium signal transducer 2",TRUE
+"202286_s_at",0.721907781985393,0.198173093732396,1.32653718524705,-5.11712085801076,1.66291991492112,"TACSTD2","tumor-associated calcium signal transducer 2",TRUE
+"202287_s_at",0.820536502908875,0.380270409398786,0.895261748008183,-5.55666809208248,0.596591144432257,"TACSTD2","tumor-associated calcium signal transducer 2",TRUE
+"202285_s_at",0.910860516303107,0.628040657438316,0.491307292133844,-5.82279376646615,0.312099865476107,"TACSTD2","tumor-associated calcium signal transducer 2",TRUE
+"225455_at",0.55074985379986,0.0489566823383382,-2.08341829774337,-4.0213586564873,-0.740578662567584,"TADA1","transcriptional adaptor 1",TRUE
+"1559289_at",0.907964244160782,0.617935687525813,0.505882027527132,-5.8157987949535,0.391159569849945,"TADA1","transcriptional adaptor 1",TRUE
+"209938_at",0.774230543658252,0.288590253453048,1.0873025028771,-5.37970657857641,0.456220723306014,"TADA2A","transcriptional adaptor 2A",TRUE
+"210537_s_at",0.961212424803935,0.823013205414012,0.226338455957957,-5.91476243442562,0.167114593057878,"TADA2A","transcriptional adaptor 2A",TRUE
+"235268_at",0.962523595451699,0.828993801734257,0.218559492468454,-5.91644407177042,0.194023014207278,"TADA2A","transcriptional adaptor 2A",TRUE
+"236248_x_at",0.156653457988943,0.00120733316773041,-3.71057792986612,-0.822693761153817,-1.84254650458728,"TADA2B","transcriptional adaptor 2B",TRUE
+"226240_at",0.382348164866486,0.0120869511423317,-2.73333707449229,-2.83756831638105,-0.950210420781143,"TADA2B","transcriptional adaptor 2B",TRUE
+"211221_at",0.6577569288805,0.126446280242918,1.58804067863964,-4.78078028575012,0.961942021052037,"TADA3","transcriptional adaptor 3",TRUE
+"215273_s_at",0.742784083548413,0.233058270750307,-1.22603184160178,-5.2329277218581,-0.451008938871048,"TADA3","transcriptional adaptor 3",TRUE
+"227205_at",0.590570903980459,0.0683312173541602,-1.91619014172695,-4.29391402796317,-0.487980158717665,"TAF1","TATA-box binding protein associated factor 1",TRUE
+"216955_at",0.988403345042769,0.944600852037947,0.0702805417758368,-5.93727798958986,0.0392115284676819,"TAF1","TATA-box binding protein associated factor 1",TRUE
+"216711_s_at",0.996200785753073,0.981023186218874,0.024056120043114,-5.93940162275059,0.00685990394712466,"TAF1","TATA-box binding protein associated factor 1",TRUE
+"235135_at",0.7768734672127,0.295105350535721,1.07234784691361,-5.39459744745807,0.311720972384844,"TAF10","TATA-box binding protein associated factor 10",TRUE
+"235906_at",0.943919772060845,0.748799858684866,0.324236753695148,-5.8886081110116,0.152080478252906,"TAF10","TATA-box binding protein associated factor 10",TRUE
+"200055_at",0.953983577550391,0.788597308972153,-0.271398302264693,-5.90387139452972,-0.079976613096516,"TAF10","TATA-box binding protein associated factor 10",TRUE
+"1558135_at",0.61760967235709,0.0880668799070374,1.78435947527321,-4.49755661985945,1.05412390366609,"TAF11","TATA-box binding protein associated factor 11",TRUE
+"209358_at",0.859064198633089,0.47579828456853,-0.725401443710393,-5.68658673517277,-0.262250290785405,"TAF11","TATA-box binding protein associated factor 11",TRUE
+"1558136_s_at",0.865854896594418,0.49598955497785,-0.692221226226782,-5.7089540235203,-0.248127274049299,"TAF11","TATA-box binding protein associated factor 11",TRUE
+"209463_s_at",0.909052380289506,0.622799323072328,0.49885337616126,-5.81919703433224,0.27708627995983,"TAF12","TATA-box binding protein associated factor 12",TRUE
+"227278_at",0.931582451098271,0.69817319202488,-0.392865390227765,-5.86478691481924,-0.188243274023693,"TAF13","TATA-box binding protein associated factor 13",TRUE
+"205966_at",0.971216837324271,0.862369287509611,0.175385995852567,-5.92471239439184,0.10190715082115,"TAF13","TATA-box binding protein associated factor 13",TRUE
+"234168_at",0.746265133825325,0.238004873771062,1.21273127701912,-5.24766578360394,0.756274702301938,"TAF15","TATA-box binding protein associated factor 15",TRUE
+"227891_s_at",0.767011398042819,0.268718122622569,1.13448054456661,-5.3315299140607,0.562497324490163,"TAF15","TATA-box binding protein associated factor 15",TRUE
+"227884_at",0.864894115958506,0.492961216654121,0.697147394968088,-5.7056963157285,0.414076592008173,"TAF15","TATA-box binding protein associated factor 15",TRUE
+"202840_at",0.904345087496977,0.606984391204394,-0.521803938861787,-5.80792936286373,-0.20904719177231,"TAF15","TATA-box binding protein associated factor 15",TRUE
+"206613_s_at",0.51531387545335,0.0356404816576763,2.2373385610834,-3.75762035818002,0.964993821176044,"TAF1A","TATA-box binding protein associated factor, RNA polymerase I subunit A",TRUE
+"238491_at",0.909706955539583,0.624457462247025,0.496462954842465,-5.82034218760128,0.340802446883643,"TAF1A-AS1","TAF1A antisense RNA 1",TRUE
+"214690_at",0.468732760220321,0.0247194222641597,2.40946795880456,-3.44952971291197,0.865093907083985,"TAF1B","TATA-box binding protein associated factor, RNA polymerase I subunit B",TRUE
+"216941_s_at",0.823074246722209,0.389140242338841,0.878424464704122,-5.57068131230079,0.299125275086881,"TAF1B","TATA-box binding protein associated factor, RNA polymerase I subunit B",TRUE
+"203938_s_at",0.527546822913581,0.0400998492919859,-2.18072070158245,-3.85599073079981,-0.791570143944602,"TAF1C","TATA-box binding protein associated factor, RNA polymerase I subunit C",TRUE
+"203937_s_at",0.96200396340887,0.827540101288692,0.220449034023611,-5.91604097706652,0.107339876336583,"TAF1C","TATA-box binding protein associated factor, RNA polymerase I subunit C",TRUE
+"218750_at",0.675158868445887,0.141346107050349,1.5252460844462,-4.86597678695791,0.727646720816155,"TAF1D","TATA-box binding protein associated factor, RNA polymerase I subunit D",TRUE
+"1553011_at",0.905462783815257,0.611631414766979,-0.515031255548703,-5.8113058226266,-0.281871443009759,"TAF1L","TATA-box binding protein associated factor 1 like",TRUE
+"1554721_a_at",0.727074488271062,0.207283881715117,1.29904781764471,-5.14956620480122,0.33963777052025,"TAF2","TATA-box binding protein associated factor 2",TRUE
+"209523_at",0.760563533925384,0.259679061105799,1.15678818496255,-5.30812130151855,0.354500719841878,"TAF2","TATA-box binding protein associated factor 2",TRUE
+"235119_at",0.697172073261335,0.166931628521518,1.42907153227951,-4.99111084196915,0.496587652887708,"TAF3","TATA-box binding protein associated factor 3",TRUE
+"235154_at",0.726696341943087,0.206896486466652,1.30019735736774,-5.14822093969418,0.654904858150312,"TAF3","TATA-box binding protein associated factor 3",TRUE
+"213090_s_at",0.673366993714442,0.139524162085237,-1.53262263209839,-4.85610956971277,-0.482202512891417,"TAF4","TATA-box binding protein associated factor 4",TRUE
+"208545_x_at",0.864894115958506,0.4938806909072,0.695649870499285,-5.7066889708393,0.644584772084394,"TAF4","TATA-box binding protein associated factor 4",TRUE
+"216226_at",0.689950875648652,0.15925465478007,1.45659415159679,-4.95597466442866,0.648354166804288,"TAF4B","TATA-box binding protein associated factor 4b",TRUE
+"235020_at",0.812302873476553,0.358057893002331,0.938596489574178,-5.51947302616548,0.726363004294339,"TAF4B","TATA-box binding protein associated factor 4b",TRUE
+"210053_at",0.956692845360826,0.803342025118626,0.252028641369774,-5.90879325979885,0.095034564171522,"TAF5","TATA-box binding protein associated factor 5",TRUE
+"1553528_a_at",0.962351204352784,0.828455354351525,0.219259279159912,-5.91629518942198,0.0902526525221639,"TAF5","TATA-box binding protein associated factor 5",TRUE
+"1554415_at",0.846015118644589,0.444002113296305,-0.779378933048409,-5.64807909304103,-0.254901811892069,"TAF5L","TATA-box binding protein associated factor 5 like",TRUE
+"213654_at",0.967106491969364,0.846634481852346,0.195692442906751,-5.92104833340026,0.0575973553141811,"TAF5L","TATA-box binding protein associated factor 5 like",TRUE
+"203572_s_at",0.897949253801113,0.585859352419912,-0.552912283534827,-5.79186944176548,-0.156784482538487,"TAF6","TATA-box binding protein associated factor 6",TRUE
+"213211_s_at",0.420796310589707,0.0174629506854695,-2.5686166866187,-3.15364338449195,-0.967814045584043,"TAF6L","TATA-box binding protein associated factor 6 like",TRUE
+"213961_s_at",0.68272466434042,0.15058432087893,-1.48899973834486,-4.91390857262276,-0.90917028794418,"TAF6L","TATA-box binding protein associated factor 6 like",TRUE
+"213210_at",0.718286618332392,0.194144300790418,-1.33900844784648,-5.10221247601593,-1.01117998745407,"TAF6L","TATA-box binding protein associated factor 6 like",TRUE
+"205955_at",0.856165275878964,0.46963425311177,-0.735693694129531,-5.67944627138699,-0.235364938244787,"TAF6L","TATA-box binding protein associated factor 6 like",TRUE
+"230049_at",0.906476756086155,0.613631648458339,0.512123579677208,-5.81274222650351,0.311018718471495,"TAF6L","TATA-box binding protein associated factor 6 like",TRUE
+"213209_at",0.948429371744093,0.765274285812351,0.302258318225859,-5.89528305245102,0.0876583256649077,"TAF6L","TATA-box binding protein associated factor 6 like",TRUE
+"222053_at",0.94943075115007,0.771488829410901,0.294007435926326,-5.89766903962379,0.201737536680064,"TAF6L","TATA-box binding protein associated factor 6 like",TRUE
+"201023_at",0.909052380289506,0.622816590244616,-0.498828468145089,-5.81920899443351,-0.200036452472864,"TAF7","TATA-box binding protein associated factor 7",TRUE
+"220325_at",0.755049574909504,0.248724418313974,1.18460767122678,-5.27836912509695,0.794167085545918,"TAF7L","TATA-box binding protein associated factor 7 like",TRUE
+"224380_s_at",0.843121215318579,0.437427630828686,-0.790828742512265,-5.63957548708824,-0.592238661775156,"TAF7L","TATA-box binding protein associated factor 7 like",TRUE
+"1556978_a_at",0.757479140651,0.253480907982298,1.1724187567192,-5.29148097612101,0.960964952611773,"TAF8","TATA-box binding protein associated factor 8",TRUE
+"1556178_x_at",0.896907177224677,0.582042207797381,0.558591763828015,-5.78883986832483,0.215481809385622,"TAF8","TATA-box binding protein associated factor 8",TRUE
+"1556176_at",0.898405288322584,0.587715981024111,0.550156473329475,-5.7933286267626,0.194529582966686,"TAF8","TATA-box binding protein associated factor 8",TRUE
+"1552494_at",0.977874971442423,0.892916093447334,-0.136170576266053,-5.93065618229133,-0.109247594284461,"TAF8","TATA-box binding protein associated factor 8",TRUE
+"229412_at",0.995244657656864,0.977933680621077,0.0279735512294803,-5.93930235150582,0.0119063048427215,"TAF8","TATA-box binding protein associated factor 8",TRUE
+"221617_at",0.720018659171833,0.195995140321754,-1.33325419400049,-5.10910579165415,-0.4271981184934,"TAF9B","TATA-box binding protein associated factor 9b",TRUE
+"226037_s_at",0.720241840968346,0.196293071280646,-1.33233190975128,-5.11020832339571,-0.503116245288684,"TAF9B","TATA-box binding protein associated factor 9b",TRUE
+"221618_s_at",0.740681080735184,0.231008577943667,-1.23160581141229,-5.22671003289955,-0.515342382792866,"TAF9B","TATA-box binding protein associated factor 9b",TRUE
+"221616_s_at",0.973493137611142,0.872145928815697,0.162807283995377,-5.92678152257043,0.048986258482639,"TAF9B","TATA-box binding protein associated factor 9b",TRUE
+"228483_s_at",0.995261077491356,0.97807723739713,0.0277915146602999,-5.93930729563539,0.0133428142325993,"TAF9B","TATA-box binding protein associated factor 9b",TRUE
+"234050_at",0.567292616148537,0.0573923497902456,2.00446507075967,-4.1519414125532,0.978992270069353,"TAGAP","T-cell activation RhoGTPase activating protein",TRUE
+"229723_at",0.672164152353115,0.137996285641238,1.53886990304305,-4.8477233741841,1.33097116987496,"TAGAP","T-cell activation RhoGTPase activating protein",TRUE
+"242388_x_at",0.761109548348834,0.260190188718575,1.15551160940576,-5.30947169141458,1.0667759779009,"TAGAP","T-cell activation RhoGTPase activating protein",TRUE
+"1552542_s_at",0.885029460971826,0.545375032185692,0.614144178495723,-5.75762743482357,0.548275825251229,"TAGAP","T-cell activation RhoGTPase activating protein",TRUE
+"1552541_at",0.954577684533304,0.792323166757454,-0.266494035841931,-5.90515178597851,-0.157550623716034,"TAGAP","T-cell activation RhoGTPase activating protein",TRUE
+"226523_at",0.498703893437511,0.0313096913349031,2.29887908002791,-3.6489883819778,0.588672374529247,"TAGLN","transgelin",TRUE
+"205547_s_at",0.649525807450256,0.120092480795878,1.61670339971274,-4.74099996802636,2.4170713263017,"TAGLN","transgelin",TRUE
+"1555724_s_at",0.673366993714442,0.139304914172835,1.533515635428,-4.85491248033143,2.55932710502313,"TAGLN","transgelin",TRUE
+"210978_s_at",0.766550448794594,0.267361184051793,1.13779375365072,-5.32807857379657,0.439318928353687,"TAGLN2","transgelin 2",TRUE
+"200916_at",0.848268984089208,0.447957247457109,0.772540689312312,-5.65310197837873,0.294518832226705,"TAGLN2","transgelin 2",TRUE
+"204743_at",0.429170076412192,0.0187602465957958,2.53610619280292,-3.2148850767242,1.31607209341691,"TAGLN3","transgelin 3",TRUE
+"1561651_s_at",0.743553048228796,0.234022257568407,1.22342320284445,-5.23582925545006,0.781333274460047,"TAL1","TAL bHLH transcription factor 1, erythroid differentiation factor",TRUE
+"216928_at",0.800179799309599,0.335803831908679,0.983865920477666,-5.47889727754436,0.375595725508073,"TAL1","TAL bHLH transcription factor 1, erythroid differentiation factor",TRUE
+"206283_s_at",0.809134610110486,0.352363878678202,-0.949993178785567,-5.50942271183505,-0.473623687609587,"TAL1","TAL bHLH transcription factor 1, erythroid differentiation factor",TRUE
+"216925_s_at",0.860087570848245,0.479541097571795,0.719190098830066,-5.69084972293691,0.502568210190137,"TAL1","TAL bHLH transcription factor 1, erythroid differentiation factor",TRUE
+"231759_at",0.67450217874052,0.140906544821505,1.52701856644296,-4.86360928657232,0.723547342481348,"TAL2","TAL bHLH transcription factor 2",TRUE
+"1553593_a_at",0.682539393883246,0.150245454002745,-1.49029675122306,-4.91220936880264,-1.06812385226166,"TAL2","TAL bHLH transcription factor 2",TRUE
+"201463_s_at",0.677807216574022,0.145181532936413,1.5099690758227,-4.88629135772521,0.551163693546446,"TALDO1","transaldolase 1",TRUE
+"226815_at",0.591331966259927,0.0688094970423252,-1.91262270273704,-4.29955915822309,-0.803991579835022,"TAMM41","TAM41 mitochondrial translocator assembly and maintenance homolog",TRUE
+"234697_x_at",0.904832003218088,0.609896055243583,0.517557539785239,-5.81005139280117,0.165266033017554,"TAMM41","TAM41 mitochondrial translocator assembly and maintenance homolog",TRUE
+"231958_at",0.907255387493016,0.616378865047749,-0.508137309010602,-5.81469857264556,-0.293727396297186,"TAMM41","TAM41 mitochondrial translocator assembly and maintenance homolog",TRUE
+"234039_at",0.812302873476553,0.36075031471817,-0.933250009238867,-5.52414951192146,-0.840564889647704,"TANC1","tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1",TRUE
+"234870_at",0.835083899263907,0.413907246836007,0.832686734412015,-5.60749749570923,0.283962726301731,"TANC1","tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1",TRUE
+"225308_s_at",0.866602763987519,0.497757324106865,-0.689353544378816,-5.71084028354214,-0.292242421792006,"TANC1","tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1",TRUE
+"224952_at",0.920147736488699,0.660140090697591,-0.445697938773283,-5.84339044603772,-0.318951281133705,"TANC2","tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2",TRUE
+"208425_s_at",0.93565329131222,0.713516083598007,0.371878635474353,-5.87254926622889,0.345909840841346,"TANC2","tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2",TRUE
+"231799_at",0.979588787486838,0.901767980045354,0.124850200748314,-5.93209419949713,0.0746080483512226,"TANC2","tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2",TRUE
+"235396_at",0.866667221107408,0.497967091926644,-0.689013643330746,-5.71106336274312,-0.227072745842491,"TANGO2","transport and golgi organization 2 homolog",TRUE
+"226467_at",0.943294768503521,0.744854136818787,-0.329524574625358,-5.886932977354,-0.102535734210203,"TANGO6","transport and golgi organization 6 homolog",TRUE
+"209451_at",0.895457620469779,0.574276144449393,-0.570204630544259,-5.78255181371371,-0.286115650631112,"TANK","TRAF family member associated NFKB activator",TRUE
+"243376_at",0.905462783815257,0.611541337560082,0.515162303601596,-5.81124089765715,0.258166201917549,"TANK","TRAF family member associated NFKB activator",TRUE
+"210458_s_at",0.950926616697165,0.775976990042263,-0.288061591067297,-5.89934785640011,-0.146705398137506,"TANK","TRAF family member associated NFKB activator",TRUE
+"207616_s_at",0.97392941021039,0.873774215781181,-0.160714981381565,-5.9271108034194,-0.0656251872246845,"TANK","TRAF family member associated NFKB activator",TRUE
+"216310_at",0.73957587762701,0.228033541651545,1.23976339499037,-5.21756652776445,0.944922784781737,"TAOK1","TAO kinase 1",TRUE
+"231193_s_at",0.759026759022785,0.25663225728935,1.16443663720364,-5.30000320454969,0.575004147333514,"TAOK1","TAO kinase 1",TRUE
+"224778_s_at",0.886030165085802,0.54871479450947,0.609005520542511,-5.76063452619913,0.188922620343746,"TAOK1","TAO kinase 1",TRUE
+"238420_at",0.912722788750542,0.633919122829429,0.482878163939193,-5.82674804787122,0.191422495252922,"TAOK1","TAO kinase 1",TRUE
+"224769_at",0.976371465776674,0.886798720920488,0.144004445883422,-5.9295881606127,0.0480540138309813,"TAOK1","TAO kinase 1",TRUE
+"227454_at",0.988419329021919,0.944771960868785,0.0700630973291509,-5.93729284974169,0.0307737677982693,"TAOK1","TAO kinase 1",TRUE
+"204986_s_at",0.73957587762701,0.228221306736129,-1.23924615509318,-5.21814782488988,-0.499580735464168,"TAOK2","TAO kinase 2",TRUE
+"204877_s_at",0.861659105448003,0.483030137044133,-0.71342531610388,-5.69477501897428,-0.243946210684271,"TAOK2","TAO kinase 2",TRUE
+"204878_s_at",0.937462538530338,0.722639182612095,-0.359480398561736,-5.87693743979134,-0.100472974230211,"TAOK2","TAO kinase 2",TRUE
+"220761_s_at",0.726696341943087,0.206848572826256,1.30033965018866,-5.14805434933164,0.607454775294631,"TAOK3","TAO kinase 3",TRUE
+"221508_at",0.839519981963042,0.427478820936482,0.808358514642512,-5.62633041555112,0.193326875353192,"TAOK3","TAO kinase 3",TRUE
+"202307_s_at",0.575947811827062,0.0610341403150617,1.97353846619383,-4.20217499712173,1.23711766212267,"TAP1","transporter 1, ATP binding cassette subfamily B member",TRUE
+"204769_s_at",0.232037111848437,0.00296612242815333,3.33715146311529,-1.61357838725391,1.97016986585356,"TAP2","transporter 2, ATP binding cassette subfamily B member",TRUE
+"225973_at",0.375303125240837,0.0114262952083111,2.7582005734557,-2.78907043498684,2.23030764494385,"TAP2","transporter 2, ATP binding cassette subfamily B member",TRUE
+"204770_at",0.517654151778308,0.0368071318786601,2.2219299148828,-3.78454380286052,2.35150462168315,"TAP2","transporter 2, ATP binding cassette subfamily B member",TRUE
+"208428_at",0.957289701021675,0.806768953126962,-0.247541148429418,-5.90988189102043,-0.255840345647527,"TAP2","transporter 2, ATP binding cassette subfamily B member",TRUE
+"1555565_s_at",0.616974366032721,0.0875443462584701,1.7875025017902,-4.49282300654714,0.781671184224402,"TAPBP","TAP binding protein (tapasin)",TRUE
+"208829_at",0.627021415091472,0.097631276840001,1.72948657631742,-4.5792109330241,0.912247090396816,"TAPBP","TAP binding protein (tapasin)",TRUE
+"210294_at",0.657015752622694,0.12572066195703,1.59125246206462,-4.77635026903379,1.01649244647931,"TAPBP","TAP binding protein (tapasin)",TRUE
+"218746_at",0.916008366263392,0.645468626787521,0.466419415075521,-5.83427621973942,0.347775127687417,"TAPBPL","TAP binding protein like",TRUE
+"218747_s_at",0.931582451098271,0.69798911404198,0.393118255478745,-5.86469082760988,0.360102372603257,"TAPBPL","TAP binding protein like",TRUE
+"227407_at",0.624520459874487,0.0961208072394821,-1.73783710279416,-4.56690642104815,-0.739908962599809,"TAPT1","transmembrane anterior posterior transformation 1",TRUE
+"242318_at",0.783844746433788,0.306785436285992,-1.04611809437421,-5.42026905816274,-0.791163030360916,"TAPT1","transmembrane anterior posterior transformation 1",TRUE
+"216373_at",0.837067957688307,0.419363677217587,-0.822846271763979,-5.61517817463148,-0.758409521139802,"TAPT1","transmembrane anterior posterior transformation 1",TRUE
+"226735_at",0.880842449447422,0.536646104516672,-0.627654349534545,-5.7496052667196,-0.237360510022846,"TAPT1","transmembrane anterior posterior transformation 1",TRUE
+"216507_at",0.903906029494077,0.605528748639333,-0.52393050509795,-5.80686031849018,-0.309389298067633,"TAPT1","transmembrane anterior posterior transformation 1",TRUE
+"238798_at",0.904832003218088,0.609611273926305,0.517972441435944,-5.80984480096875,0.297928543081568,"TAPT1","transmembrane anterior posterior transformation 1",TRUE
+"1553145_at",0.728523962638265,0.209961499487143,-1.29114756437793,-5.15878426107814,-0.470634871158187,"TAPT1-AS1","TAPT1 antisense RNA 1 (head to head)",TRUE
+"202813_at",0.940044918888428,0.731354044849548,0.347690362649458,-5.88097402226982,0.135149783797758,"TARBP1","TAR (HIV-1) RNA binding protein 1",TRUE
+"203677_s_at",0.742784083548413,0.233052748666012,-1.22604680841236,-5.23291105918789,-0.43527689303391,"TARBP2","TARBP2, RISC loading complex RNA binding subunit",TRUE
+"239389_at",0.890791272165577,0.559576870813578,0.592405518580502,-5.77018197618055,0.471977149955052,"TARBP2","TARBP2, RISC loading complex RNA binding subunit",TRUE
+"221264_s_at",0.94632739401154,0.757295862247276,-0.312882633685047,-5.89211433134299,-0.107741144678787,"TARDBP","TAR DNA binding protein",TRUE
+"200020_at",0.974451535839172,0.875100042091167,-0.159011874900835,-5.92737569703379,-0.0361479324265268,"TARDBP","TAR DNA binding protein",TRUE
+"1558208_at",0.985498770484702,0.929925093055851,-0.0889445038686871,-5.93583099801115,-0.028400182764245,"TARDBP","TAR DNA binding protein",TRUE
+"216298_at",0.661974206478491,0.129604521358691,-1.57423746267002,-4.79973942749723,-1.14199133273634,"TARP","TCR gamma alternate reading frame protein",TRUE
+"217381_s_at",0.958794064221941,0.813557601672912,-0.238666771522142,-5.91197749486407,-0.151055614678873,"TARP","TCR gamma alternate reading frame protein",TRUE
+"209813_x_at",0.699161781955613,0.17055199893419,-1.41644406123336,-5.00704784729526,-2.01722271738706,"TARP///TRGV9///TRGC2","TCR gamma alternate reading frame protein///T cell receptor gamma variable 9///T cell receptor gamma constant 2",TRUE
+"215806_x_at",0.727286289873957,0.207546262474404,-1.29827018639461,-5.15047566647059,-1.5990678586908,"TARP///TRGV9///TRGC2","TCR gamma alternate reading frame protein///T cell receptor gamma variable 9///T cell receptor gamma constant 2",TRUE
+"211144_x_at",0.772153322615079,0.282496736986508,-1.10151120093537,-5.36538828269654,-1.19018965124906,"TARP///TRGV9///TRGC2","TCR gamma alternate reading frame protein///T cell receptor gamma variable 9///T cell receptor gamma constant 2",TRUE
+"216920_s_at",0.85492369444809,0.46699576095156,-0.740123610780859,-5.67634353449794,-0.84808901235732,"TARP///TRGV9///TRGC2","TCR gamma alternate reading frame protein///T cell receptor gamma variable 9///T cell receptor gamma constant 2",TRUE
+"201263_at",0.422574093216884,0.0176835761368126,2.56293161460936,-3.16438106696019,0.937035802149545,"TARS","threonyl-tRNA synthetase",TRUE
+"240206_at",0.463552233135475,0.0236228710724829,2.43046984398613,-3.41106174426151,0.897788192321438,"TARS","threonyl-tRNA synthetase",TRUE
+"227611_at",0.663325052838397,0.131374589838719,-1.56662296846195,-4.81014265338655,-0.64466329822154,"TARSL2","threonyl-tRNA synthetase like 2",TRUE
+"244615_x_at",0.999503346640971,0.998747021352842,-0.00158818968592664,-5.93968225220721,-0.000671320741752801,"TARSL2","threonyl-tRNA synthetase like 2",TRUE
+"1555417_a_at",0.290430545694223,0.00505298963243215,3.11190733192108,-2.08012673639631,1.52278319553276,"TAS1R1","taste 1 receptor member 1",TRUE
+"1564883_a_at",0.663129351367592,0.131127709760103,1.56767987648958,-4.80870103006661,1.17404714543358,"TAS1R1","taste 1 receptor member 1",TRUE
+"1553529_at",0.97304633500821,0.869054216966037,-0.166782102665184,-5.92614427591177,-0.110492154624128,"TAS1R2","taste 1 receptor member 2",TRUE
+"221324_at",0.871744769522775,0.51363552984944,0.663849944770456,-5.72728611082995,0.183853146764638,"TAS2R1","taste 2 receptor member 1",TRUE
+"221397_at",0.926430328514448,0.680166645415436,0.417727644821844,-5.85504826203634,0.239223054079439,"TAS2R10","taste 2 receptor member 10",TRUE
+"221395_at",0.867026157046741,0.498590766600673,0.688003541560291,-5.71172567870339,0.508725809130549,"TAS2R13","taste 2 receptor member 13",TRUE
+"235762_at",0.633098477100746,0.104385148288178,1.69344447221651,-4.63181052328815,0.97670611927728,"TAS2R14","taste 2 receptor member 14",TRUE
+"221391_at",0.975196332002567,0.879491959155376,-0.15337359237684,-5.92823256189581,-0.0835120632378965,"TAS2R14","taste 2 receptor member 14",TRUE
+"236637_at",0.97928472590149,0.899305616120912,-0.127997491960205,-5.93170690022944,-0.119108834574577,"TAS2R14","taste 2 receptor member 14",TRUE
+"221444_at",0.690381347688918,0.16020441655405,1.45313192065793,-4.96042466195456,0.423650979844771,"TAS2R16","taste 2 receptor member 16",TRUE
+"1570384_at",0.737488397392592,0.223539379268194,1.25224155493853,-5.20347982415306,1.18063679592001,"TAS2R19","taste 2 receptor member 19",TRUE
+"221456_at",0.731054546207485,0.213587548660738,1.28057226169898,-5.17104871755343,0.305450868124247,"TAS2R3","taste 2 receptor member 3",TRUE
+"1553555_at",0.399915701489204,0.0142631114385724,2.65966336117595,-2.98009130902423,1.71609718354177,"TAS2R38","taste 2 receptor member 38",TRUE
+"1553553_at",0.89390639630277,0.569617459452194,0.577209023658915,-5.77869850812993,0.234215678431921,"TAS2R39","taste 2 receptor member 39",TRUE
+"221392_at",0.813021058415276,0.362115936251099,0.930548452706903,-5.52650318558479,0.455130989591527,"TAS2R4","taste 2 receptor member 4",TRUE
+"1553556_at",0.861962516141708,0.484541335472059,0.710935940178056,-5.69646076218415,0.451798162341102,"TAS2R40","taste 2 receptor member 40",TRUE
+"1553558_at",0.971216837324271,0.862774690254607,0.174863839474426,-5.92480133953165,0.128112578903882,"TAS2R41","taste 2 receptor member 41",TRUE
+"234108_at",0.605169025480065,0.0790178632446673,1.84122606286333,-4.41098162577733,0.690694688564465,"TAS2R45","taste 2 receptor member 45",TRUE
+"234042_at",0.94895689004559,0.768246084172723,-0.298310105015579,-5.8964329638069,-0.218818891794923,"TAS2R45///TAS2R43","taste 2 receptor member 45///taste 2 receptor member 43",TRUE
+"231757_at",0.819018525257656,0.374166572245666,0.906998680538926,-5.54675418619713,0.618662111586636,"TAS2R5","taste 2 receptor member 5",TRUE
+"1553561_at",0.663819586595936,0.131881654962,1.56445734245951,-4.81309418229629,0.598944516941327,"TAS2R50","taste 2 receptor member 50",TRUE
+"221396_at",0.936992192746977,0.718914825137264,-0.364534733844438,-5.87516626587369,-0.262542229781679,"TAS2R7","taste 2 receptor member 7",TRUE
+"221398_at",0.990810941805126,0.954038766425261,-0.0582917595769413,-5.93802861021082,-0.0209572695190499,"TAS2R8","taste 2 receptor member 8",TRUE
+"221461_at",0.812302873476553,0.359621746233447,0.935487792823606,-5.52219514250815,0.555386706532288,"TAS2R9","taste 2 receptor member 9",TRUE
+"219443_at",0.87825462101175,0.530564147929877,0.637137558974715,-5.74387390278337,0.218396291130627,"TASP1","taspase 1",TRUE
+"233719_s_at",0.885929137203218,0.548054198598991,0.610020618238685,-5.76004243286785,0.259510137225681,"TASP1","taspase 1",TRUE
+"1555189_a_at",0.73957587762701,0.227964590767216,1.23995341664668,-5.21735292055207,0.867237057940745,"TAT","tyrosine aminotransferase",TRUE
+"214413_at",0.766550448794594,0.267558700061457,-1.13731071599905,-5.32858230250014,-0.764077988503319,"TAT","tyrosine aminotransferase",TRUE
+"206916_x_at",0.842928408549809,0.436878695168742,0.791789506774427,-5.63885663107407,0.352912890933831,"TAT","tyrosine aminotransferase",TRUE
+"223231_at",0.863230457544525,0.487324578007669,0.706362880495305,-5.69954289839279,0.401096769833419,"TATDN1","TatD DNase domain containing 1",TRUE
+"1565580_s_at",0.720021194788968,0.196072532461343,1.33301451102433,-5.10939237898379,0.786169297371852,"TATDN2","TatD DNase domain containing 2",TRUE
+"203648_at",0.895657764833717,0.575151062239836,-0.568892398543179,-5.78326863791967,-0.163193662951713,"TATDN2","TatD DNase domain containing 2",TRUE
+"228867_at",0.630603891142543,0.101735630563054,-1.70734020257459,-4.61162949234712,-0.844552308782951,"TATDN3","TatD DNase domain containing 3",TRUE
+"235069_at",0.806649582904638,0.347630510136086,-0.959562293873975,-5.50089826551257,-0.499604849562102,"TATDN3","TatD DNase domain containing 3",TRUE
+"200976_s_at",0.867834927246481,0.500789181482208,0.684448705839565,-5.71404917422846,0.262568669571699,"TAX1BP1","Tax1 binding protein 1",TRUE
+"200977_s_at",0.893600768892136,0.568835579872097,0.578387443179675,-5.77804575036212,0.177657512707157,"TAX1BP1","Tax1 binding protein 1",TRUE
+"213786_at",0.986421906591669,0.936717428262267,-0.0803027087351574,-5.93654312997233,-0.0369107140598128,"TAX1BP1","Tax1 binding protein 1",TRUE
+"37278_at",0.784498961298069,0.307664662233636,-1.04417253972789,-5.42215046847436,-0.379050259237935,"TAZ","tafazzin",TRUE
+"203977_at",0.812302873476553,0.360420865376076,-0.933902772293828,-5.52357986529437,-0.762684819112941,"TAZ","tafazzin",TRUE
+"1552887_at",0.977916262155425,0.893369208269578,-0.135590673340427,-5.93073287282251,-0.0476883468246792,"TBATA","thymus, brain and testes associated",TRUE
+"227945_at",0.718706241731185,0.194768734707874,1.33706229714765,-5.10454666007156,0.806831714148913,"TBC1D1","TBC1 domain family member 1",TRUE
+"214013_s_at",0.731054546207485,0.213865809355803,1.2797664608777,-5.17197970374554,0.854768167591066,"TBC1D1","TBC1 domain family member 1",TRUE
+"212350_at",0.732963666545614,0.217323818116227,1.26981934787882,-5.18343096541258,1.00183890430066,"TBC1D1","TBC1 domain family member 1",TRUE
+"1569566_at",0.884749233889577,0.544199418569363,-0.615956978639275,-5.75656078877399,-0.646140188896581,"TBC1D1","TBC1 domain family member 1",TRUE
+"1568713_a_at",0.990991141753796,0.957912790885929,-0.0533733042319332,-5.93829607457839,-0.0268514236299673,"TBC1D1","TBC1 domain family member 1",TRUE
+"226133_s_at",0.917166618334994,0.649934060290736,-0.460091035013681,-5.83710276541928,-0.148985784061615,"TBC1D10A","TBC1 domain family member 10A",TRUE
+"1570035_at",0.979588787486838,0.902313959068462,-0.12415252910744,-5.93217874997577,-0.04928582514263,"TBC1D10A","TBC1 domain family member 10A",TRUE
+"220947_s_at",0.580630437263151,0.0631303127952055,-1.95647096640594,-4.22967092787075,-0.55375857275445,"TBC1D10B","TBC1 domain family member 10B",TRUE
+"228258_at",0.275695698477361,0.00442222455536617,3.16863515651373,-1.96356779193777,1.64659923784555,"TBC1D10C","TBC1 domain family member 10C",TRUE
+"1557609_s_at",0.716219454102037,0.191903896687452,-1.34603171649885,-5.09376519334838,-0.494939974342241,"TBC1D12","TBC1 domain family member 12",TRUE
+"221858_at",0.750621910660972,0.243603752771254,-1.19792616,-5.2639070291763,-0.435231317489855,"TBC1D12","TBC1 domain family member 12",TRUE
+"218596_at",0.319095917986488,0.00702535714881205,-2.97052388438507,-2.36744780316834,-1.03857435203188,"TBC1D13","TBC1 domain family member 13",TRUE
+"44696_at",0.399312926596283,0.0141256685543871,-2.66399147549583,-2.97176873511561,-0.676846880190254,"TBC1D13","TBC1 domain family member 13",TRUE
+"224622_at",0.580152731323135,0.0627243630200392,-1.95973678874626,-4.22442222505706,-0.593200731137353,"TBC1D14","TBC1 domain family member 14",TRUE
+"230072_at",0.963414760041184,0.83321500399282,-0.213077293557495,-5.91759403594438,-0.0948709532396803,"TBC1D15","TBC1 domain family member 15",TRUE
+"218268_at",0.988713664405312,0.945623670485514,-0.0689807992928253,-5.93736612930744,-0.0209659663572683,"TBC1D15","TBC1 domain family member 15",TRUE
+"228488_at",0.625075149000452,0.0963764701613865,-1.73641584004871,-4.56900376112766,-1.16582645095201,"TBC1D16","TBC1 domain family member 16",TRUE
+"222116_s_at",0.816800680706682,0.368212893519479,-0.918569463189159,-5.53686396858075,-0.517613947481475,"TBC1D16","TBC1 domain family member 16",TRUE
+"1554701_a_at",0.822862741321714,0.388668288495209,-0.87931401121472,-5.56994713877137,-0.36102769719587,"TBC1D16","TBC1 domain family member 16",TRUE
+"222648_at",0.905306717560218,0.611030974378137,0.515904973763573,-5.81087265337815,0.485270220899214,"TBC1D16","TBC1 domain family member 16",TRUE
+"1558066_s_at",0.932091525948902,0.700657906028534,-0.389454716666681,-5.86607699700598,-0.235022456878388,"TBC1D16","TBC1 domain family member 16",TRUE
+"218466_at",0.743474458360704,0.233838368380943,-1.22392019507685,-5.23527687332564,-0.43156865959287,"TBC1D17","TBC1 domain family member 17",TRUE
+"220260_at",0.805963877180466,0.346268184366729,-0.96233279416509,-5.49841563413168,-0.806083708197499,"TBC1D19","TBC1 domain family member 19",TRUE
+"222173_s_at",0.588653540532996,0.0674626780685462,1.92272494536938,-4.28355442453169,1.84469786548223,"TBC1D2","TBC1 domain family member 2",TRUE
+"226409_at",0.825992937578802,0.393570749682927,-0.870107732297284,-5.5775120157456,-0.311736791092255,"TBC1D20","TBC1 domain family member 20",TRUE
+"226664_at",0.856063712917985,0.469426912849977,-0.736041275801848,-5.67920346230737,-0.208580815487457,"TBC1D20","TBC1 domain family member 20",TRUE
+"231475_at",0.949242806974533,0.770922315517095,0.294758709871144,-5.89745449596192,0.095182416450621,"TBC1D21","TBC1 domain family member 21",TRUE
+"209650_s_at",0.596382916302699,0.0727837627086612,1.88379191743893,-4.34491170696911,1.28496805731653,"TBC1D22A","TBC1 domain family member 22A",TRUE
+"33778_at",0.774230543658252,0.28986227227309,1.08436380780843,-5.38264726900985,0.376965296205778,"TBC1D22A","TBC1 domain family member 22A",TRUE
+"210144_at",0.98904977153777,0.94686478631187,0.067403819565318,-5.93747086131214,0.0315620112724613,"TBC1D22A","TBC1 domain family member 22A",TRUE
+"1561099_at",0.988713664405312,0.945544308497542,0.0690816438373087,-5.93735934956058,0.0409244180584047,"TBC1D22A-AS1","TBC1D22A antisense RNA 1",TRUE
+"216549_s_at",0.698391916012681,0.169381672718813,1.42050233118021,-5.00193860093289,0.575993421214772,"TBC1D22B","TBC1 domain family member 22B",TRUE
+"223375_at",0.89967769475675,0.591035742330602,0.54523962104125,-5.7959144801012,0.154406252814491,"TBC1D22B","TBC1 domain family member 22B",TRUE
+"233430_at",0.934081042629428,0.708441572267913,-0.378800524392161,-5.87003550633561,-0.23186187315242,"TBC1D22B","TBC1 domain family member 22B",TRUE
+"225121_at",0.937865391672415,0.725213955722475,0.355991745588146,-5.8781457100624,0.117357169695461,"TBC1D23","TBC1 domain family member 23",TRUE
+"227908_at",0.567115935569868,0.0571538859358448,-2.00655034509047,-4.14853548208557,-0.824850981805634,"TBC1D24","TBC1 domain family member 24",TRUE
+"227632_at",0.864894115958506,0.493124300821671,-0.696881667329273,-5.70587260566258,-0.280540289047611,"TBC1D24","TBC1 domain family member 24",TRUE
+"226173_at",0.974670398319743,0.876279108907379,-0.157497694680714,-5.92760884180928,-0.0416793143592411,"TBC1D25","TBC1 domain family member 25",TRUE
+"227820_at",0.985498770484702,0.92968403024791,-0.0892513283516362,-5.93580437809616,-0.0267894481538073,"TBC1D25","TBC1 domain family member 25",TRUE
+"233483_at",0.845444642968895,0.44245629670748,0.782061670206624,-5.64609714614845,0.378249216181901,"TBC1D27","TBC1 domain family member 27",TRUE
+"233462_at",0.847634885848566,0.44649080406838,0.77507179891703,-5.65124767423661,0.540620141814742,"TBC1D28","TBC1 domain family member 28",TRUE
+"208008_at",0.790165216824181,0.319274439324734,-1.01884249652943,-5.44635717396682,-0.760354531676324,"TBC1D29","TBC1 domain family member 29",TRUE
+"212796_s_at",0.94333312187812,0.745668741747275,0.328432109496121,-5.88728125841218,0.151153077575573,"TBC1D2B","TBC1 domain family member 2B",TRUE
+"215951_at",0.978928101156583,0.897175695837788,-0.130720934788812,-5.93136398980831,-0.0527825487976781,"TBC1D2B","TBC1 domain family member 2B",TRUE
+"215640_at",0.980953956539862,0.910439610655026,0.113776538379554,-5.93338036571864,0.0346916794536059,"TBC1D2B","TBC1 domain family member 2B",TRUE
+"230377_s_at",0.981508003489034,0.91219656690646,-0.111534727426751,-5.93362623344963,-0.0914021035400507,"TBC1D2B","TBC1 domain family member 2B",TRUE
+"213912_at",0.493378740589161,0.0297474409134768,-2.32300725180019,-3.60592673565056,-2.0158163519714,"TBC1D30","TBC1 domain family member 30",TRUE
+"213913_s_at",0.533077882131304,0.0420222345127741,-2.15805936254989,-3.89492804979913,-1.74837060457794,"TBC1D30","TBC1 domain family member 30",TRUE
+"215186_at",0.73957587762701,0.227747515243479,-1.24055194072856,-5.21667992327827,-0.582584303715786,"TBC1D30","TBC1 domain family member 30",TRUE
+"1556429_a_at",0.683017520100356,0.151457322449937,1.48566924265637,-4.91826636758356,1.59684300506366,"TBC1D31","TBC1 domain family member 31",TRUE
+"214061_at",0.908466056355731,0.619501073585371,0.503617017741555,-5.81689895736675,0.273885311354695,"TBC1D31","TBC1 domain family member 31",TRUE
+"1553726_s_at",0.756584150514497,0.251885482051614,1.17648801989036,-5.2871167667088,0.987584899529024,"TBC1D32","TBC1 domain family member 32",TRUE
+"232038_at",0.852600937296709,0.458652461480011,0.754230353803084,-5.66634550062137,0.372661613678383,"TBC1D32","TBC1 domain family member 32",TRUE
+"209403_at",0.88113080359582,0.537595868759173,0.626178682229318,-5.75048967789549,0.47907189414498,"TBC1D3I///TBC1D3E///LOC101060389///TBC1D3L///TBC1D3K///TBC1D3G///TBC1D3H///TBC1D3///TBC1D3C///TBC1D3F","TBC1 domain family member 3I///TBC1 domain family member 3E///TBC1 domain family member-like///TBC1 domain family member 3L///TBC1 domain family member 3K///TBC1 domain family member 3G///TBC1 domain family member 3H///TBC1 domain family member 3///TBC1 domain family member 3C///TBC1 domain family member 3F",TRUE
+"221194_s_at",0.97928472590149,0.899491907181843,-0.127759336573352,-5.93173654381363,-0.0692474863623911,"TBC1D3P1-DHX40P1///RNFT1","TBC1D3P1-DHX40P1 readthrough, transcribed pseudogene///ring finger protein, transmembrane 1",TRUE
+"203387_s_at",0.693742297578797,0.16297717032241,1.44311816128855,-4.97324680023555,0.567815158444573,"TBC1D4","TBC1 domain family member 4",TRUE
+"203386_at",0.746766793112708,0.238664891501627,1.2109724401144,-5.24960428990006,0.574914923390812,"TBC1D4","TBC1 domain family member 4",TRUE
+"201815_s_at",0.702809964629668,0.174460888008149,1.40304893813612,-5.02382654320371,0.341888941611016,"TBC1D5","TBC1 domain family member 5",TRUE
+"201813_s_at",0.883515015273005,0.541720864255122,0.619785753703217,-5.75429799074887,0.277730983659747,"TBC1D5","TBC1 domain family member 5",TRUE
+"201814_at",0.988065316951061,0.943059204174958,0.0722398198542399,-5.9371420168195,0.0253551993546353,"TBC1D5","TBC1 domain family member 5",TRUE
+"223461_at",0.813375393746656,0.363225854846243,0.928357765410516,-5.5284071685367,0.321060966653745,"TBC1D7","TBC1 domain family member 7",TRUE
+"1563839_at",0.872668627020452,0.516529934794785,0.659248725767122,-5.73018995422728,0.317276646653994,"TBC1D7","TBC1 domain family member 7",TRUE
+"204526_s_at",0.729716671990386,0.211941486076037,1.2853556464614,-5.16551193362778,0.802136327347934,"TBC1D8","TBC1 domain family member 8",TRUE
+"221592_at",0.963737076458538,0.834339567869131,0.211617922622808,-5.91789525699941,0.164926397773485,"TBC1D8","TBC1 domain family member 8",TRUE
+"241017_at",0.97689149311934,0.889249495664581,0.140864918936243,-5.93002334236448,0.0800663841353719,"TBC1D8///RPL31","TBC1 domain family member 8///ribosomal protein L31",TRUE
+"1563272_at",0.612420348961838,0.0843531394384033,1.80705652162868,-4.46323739908002,0.663080758896525,"TBC1D8B","TBC1 domain family member 8B",TRUE
+"219771_at",0.837368340567858,0.420500332112962,0.82080651891522,-5.61675954536447,0.706822084926354,"TBC1D8B","TBC1 domain family member 8B",TRUE
+"238067_at",0.906476756086155,0.613922796816949,0.511700719804748,-5.81295046065772,0.638836313787987,"TBC1D8B","TBC1 domain family member 8B",TRUE
+"212956_at",0.193135146672022,0.00197815605187622,-3.50628311788553,-1.25756291984037,-2.78945103072047,"TBC1D9","TBC1 domain family member 9",TRUE
+"212960_at",0.586395668838578,0.0660667091000574,-1.93338472940685,-4.26660322309831,-1.10343068437517,"TBC1D9","TBC1 domain family member 9",TRUE
+"237091_at",0.647754107214051,0.119201468158018,1.6208235831958,-4.7352363592379,0.578382167478158,"TBC1D9","TBC1 domain family member 9",TRUE
+"212052_s_at",0.250373992456606,0.00353239003886442,-3.26367223533979,-1.76683192525527,-1.09921547365086,"TBC1D9B","TBC1 domain family member 9B",TRUE
+"206431_x_at",0.636147339487472,0.107518432502223,-1.67739264776245,-4.65496801886142,-0.525679583104219,"TBC1D9B","TBC1 domain family member 9B",TRUE
+"215994_x_at",0.73223722457785,0.216123816786157,-1.273257311224,-5.17948175675359,-0.341996358648538,"TBC1D9B","TBC1 domain family member 9B",TRUE
+"212054_x_at",0.740610299769501,0.230679726697636,-1.23250358590881,-5.22570630208427,-0.334555965664871,"TBC1D9B","TBC1 domain family member 9B",TRUE
+"203667_at",0.711902920992134,0.1855034881198,-1.36645766806629,-5.06898779085016,-0.385833366955087,"TBCA","tubulin folding cofactor A",TRUE
+"201804_x_at",0.623667408398064,0.0950077965047586,-1.74406240106059,-4.55770484086939,-0.638187050274434,"TBCB","tubulin folding cofactor B",TRUE
+"216194_s_at",0.639803868019288,0.110290835959429,-1.66351642015478,-4.67485209316455,-0.666645677980181,"TBCB","tubulin folding cofactor B",TRUE
+"211759_x_at",0.673766817862474,0.140360385102032,-1.52922722951613,-4.86065612014595,-0.559075170289578,"TBCB","tubulin folding cofactor B",TRUE
+"202495_at",0.74093672568168,0.231218334038972,-1.23103367733522,-5.22734936171349,-0.334932918151411,"TBCC","tubulin folding cofactor C",TRUE
+"206451_at",0.899061060612873,0.589254129833268,0.547876644714205,-5.79453043005053,0.187260257125256,"TBCCD1","TBCC domain containing 1",TRUE
+"201759_at",0.500605801567359,0.0318525161147914,-2.29075334576709,-3.66343150656372,-1.35739434795006,"TBCD","tubulin folding cofactor D",TRUE
+"211052_s_at",0.868711179765034,0.504813746748873,-0.677963803126592,-5.71825816426942,-0.262483492653068,"TBCD","tubulin folding cofactor D",TRUE
+"229767_at",0.88113080359582,0.537719440197131,-0.625986789841357,-5.75060453743022,-0.380006184583676,"TBCD","tubulin folding cofactor D",TRUE
+"203715_at",0.34587800511312,0.00884384912936702,-2.87063429681772,-2.5673999059457,-1.03909354821805,"TBCE","tubulin folding cofactor E",TRUE
+"203714_s_at",0.606900628956089,0.0804682190320696,-1.83174394924522,-4.4255531291847,-0.558693987556675,"TBCE","tubulin folding cofactor E",TRUE
+"227395_at",0.329882019967271,0.00790992827027146,-2.9191881899032,-2.47054403482402,-1.01305000636592,"TBCEL","tubulin folding cofactor E like",TRUE
+"231997_at",0.657015752622694,0.125649027002182,-1.5915703740029,-4.77591139316715,-0.485532754056576,"TBCEL","tubulin folding cofactor E like",TRUE
+"222365_at",0.819018525257656,0.374799945756638,-0.905774935501272,-5.54779342552331,-0.623523299672098,"TBCEL","tubulin folding cofactor E like",TRUE
+"226126_at",0.615821255316333,0.0867421050019418,-1.79235958074622,-4.485495982915,-0.690985849443376,"TBCK","TBC1 domain containing kinase",TRUE
+"218520_at",0.347515673982638,0.00900846185161342,-2.86258715116864,-2.58338884746266,-0.872911099059428,"TBK1","TANK binding kinase 1",TRUE
+"205424_at",0.606900628956089,0.0806427847615922,-1.83061270094867,-4.42728796192142,-1.26414677699173,"TBKBP1","TBK1 binding protein 1",TRUE
+"201868_s_at",0.559167054471987,0.0528880852159276,-2.04522513967778,-4.08494129014459,-1.19901168098843,"TBL1X","transducin (beta)-like 1X-linked",TRUE
+"213400_s_at",0.731965025847759,0.215665393982554,-1.27457455388108,-5.17796621670066,-1.369574710512,"TBL1X","transducin (beta)-like 1X-linked",TRUE
+"201867_s_at",0.752235160137581,0.245406832215346,-1.1932127558416,-5.26904125131973,-0.891762465554267,"TBL1X","transducin (beta)-like 1X-linked",TRUE
+"201869_s_at",0.761938937378388,0.261323803451661,-1.15268693412592,-5.31245504030111,-0.966822164797955,"TBL1X","transducin (beta)-like 1X-linked",TRUE
+"213401_s_at",0.826140850652187,0.393978952988444,-0.869344532393866,-5.57813582352512,-0.289822482079034,"TBL1X","transducin (beta)-like 1X-linked",TRUE
+"1570293_at",0.878278790222455,0.53099461311652,-0.636464434590231,-5.7442834443649,-0.400717018677586,"TBL1X","transducin (beta)-like 1X-linked",TRUE
+"222633_at",0.604824625238112,0.0788802378131979,1.84213366355741,-4.40958406402912,0.716698260084366,"TBL1XR1","transducin (beta)-like 1 X-linked receptor 1",TRUE
+"235890_at",0.689985677226298,0.159488596045468,1.45573980383656,-4.95707355540505,0.744675155308498,"TBL1XR1","transducin (beta)-like 1 X-linked receptor 1",TRUE
+"222634_s_at",0.691497416459637,0.161154777905008,1.44968406122981,-4.96484762863042,0.652847251983184,"TBL1XR1","transducin (beta)-like 1 X-linked receptor 1",TRUE
+"223013_at",0.731548533938014,0.214890067937389,1.27680730740863,-5.17539429074969,0.429796604308113,"TBL1XR1","transducin (beta)-like 1 X-linked receptor 1",TRUE
+"233633_at",0.800053470634826,0.335485057636512,0.984529058322951,-5.47828993980912,0.701684120738651,"TBL1XR1","transducin (beta)-like 1 X-linked receptor 1",TRUE
+"221428_s_at",0.872010957446544,0.514782470559595,0.662024941852145,-5.72844019230072,0.237962388361652,"TBL1XR1","transducin (beta)-like 1 X-linked receptor 1",TRUE
+"211462_s_at",0.823527444551674,0.39059375751466,0.875689254140396,-5.57293445547262,0.577193023429108,"TBL1Y","transducin (beta)-like 1, Y-linked",TRUE
+"212679_at",0.71105346200454,0.18489796492856,1.36841875452793,-5.06659254618072,0.467076137633351,"TBL2","transducin (beta)-like 2",TRUE
+"212685_s_at",0.871708868449496,0.513299808316992,-0.664384570883323,-5.72694745143237,-0.245167786284375,"TBL2","transducin (beta)-like 2",TRUE
+"1564683_at",0.687734660055697,0.156891236140933,1.4652827370094,-4.94476940072714,1.0728920707183,"TBL3","transducin beta like 3",TRUE
+"209820_s_at",0.954014881715784,0.788844239368796,0.271073063967967,-5.90395702457329,0.0916109640378995,"TBL3","transducin beta like 3",TRUE
+"203135_at",0.945764550538403,0.755135063828875,0.315766303045236,-5.89123556169967,0.0848605407019303,"TBP","TATA-box binding protein",TRUE
+"208398_s_at",0.808257777979515,0.35093244428817,0.952877767792287,-5.50686127163548,0.408832367680258,"TBPL1","TATA-box binding protein like 1",TRUE
+"220025_at",0.724970327905974,0.202634505002316,-1.31295584788674,-5.13322249789254,-0.786323951186387,"TBR1","T-box, brain 1",TRUE
+"226318_at",0.895690630367785,0.576156987854167,0.567384922315094,-5.78409014109682,0.310901908671179,"TBRG1","transforming growth factor beta regulator 1",TRUE
+"230681_at",0.940567117317801,0.733905634862423,0.344247965957421,-5.88212751355991,0.221694064052164,"TBRG1","transforming growth factor beta regulator 1",TRUE
+"225819_at",0.941306621461417,0.737178230408628,0.339839040317156,-5.88358829871371,0.116928220077464,"TBRG1","transforming growth factor beta regulator 1",TRUE
+"225818_s_at",0.962808206628386,0.831048584036568,0.215890041442085,-5.91700765720566,0.108961409699135,"TBRG1","transforming growth factor beta regulator 1",TRUE
+"230320_at",0.979588787486838,0.90259924668517,0.123788003452085,-5.93222273848902,0.0695030648947057,"TBRG1","transforming growth factor beta regulator 1",TRUE
+"242701_at",0.990810941805126,0.954082334603574,0.0582364375258314,-5.93803174958804,0.0179792277238446,"TBRG1","transforming growth factor beta regulator 1",TRUE
+"220961_s_at",0.61760967235709,0.0879615459316549,-1.78499176081835,-4.49660484251764,-0.603400542621599,"TBRG4","transforming growth factor beta regulator 4",TRUE
+"242941_x_at",0.717937808890208,0.193707675128281,1.34037218197119,-5.10057513575014,1.2242262399936,"TBX1","T-box 1",TRUE
+"236926_at",0.85463333818278,0.46636969843627,-0.74117691816801,-5.67560319270939,-0.942309293623343,"TBX1","T-box 1",TRUE
+"211274_at",0.93613089056626,0.714618540363949,0.370377284549698,-5.87308846184359,0.246152428498838,"TBX1","T-box 1",TRUE
+"211273_s_at",0.94895689004559,0.76924330864056,0.296986319319706,-5.89681515895498,0.483881624000516,"TBX1","T-box 1",TRUE
+"207662_at",0.990918916504081,0.957403252495943,-0.0540201336344947,-5.93826224532602,-0.0168200980337971,"TBX1","T-box 1",TRUE
+"207689_at",0.635821858586292,0.106870842749101,-1.68067745691774,-4.65024269100985,-0.425405937485423,"TBX10","T-box 10",TRUE
+"222377_at",0.898251132927101,0.587350274408355,0.550698953629478,-5.79304194638564,0.246737645109853,"TBX10","T-box 10",TRUE
+"230438_at",0.827367352058381,0.396152718967286,0.865288923474268,-5.5814421715857,0.546935253387718,"TBX15","T-box 15",TRUE
+"1559840_s_at",0.724067243569133,0.201413215587422,1.31665030242187,-5.12885630593357,1.15761293749944,"TBX18","T-box 18",TRUE
+"233889_at",0.728343447580122,0.208651914393186,1.29500165558574,-5.15429325180285,0.871047689025603,"TBX18","T-box 18",TRUE
+"242107_x_at",0.812302873476553,0.357326223287013,-0.94005407004037,-5.51819384712356,-1.37737348470021,"TBX18","T-box 18",TRUE
+"1559839_at",0.980009054680439,0.905503230047539,-0.120078413124349,-5.93266304185888,-0.108674086862307,"TBX18","T-box 18",TRUE
+"243494_at",0.957481612329989,0.808172271191891,-0.24570503544105,-5.91032171290222,-0.154959522963941,"TBX18-AS1","TBX18 antisense RNA 1",TRUE
+"206838_at",0.886943633644753,0.550782730833126,0.605832007240593,-5.76247945797487,0.498900881609798,"TBX19","T-box 19",TRUE
+"213417_at",0.743553048228796,0.234257412169373,-1.22278808772621,-5.2365348720439,-1.75029699295819,"TBX2","T-box 2",TRUE
+"40560_at",0.784925710185113,0.310212850206506,-1.0385560145101,-5.4275641353914,-1.37929634649468,"TBX2","T-box 2",TRUE
+"205993_s_at",0.863982129426672,0.490522937442166,-0.701126326739801,-5.7030489325865,-0.577337813623982,"TBX2","T-box 2",TRUE
+"221977_at",0.990810941805126,0.955512629281277,-0.0564203786917313,-5.93813315152236,-0.04286311016816,"TBX2","T-box 2",TRUE
+"228978_at",0.835838027302116,0.4152636341511,-0.8302329349812,-5.60942073084243,-1.02182183336797,"TBX2-AS1","TBX2 antisense RNA 1",TRUE
+"1564945_at",0.896229101808264,0.580159791500684,-0.561399427064551,-5.78733109580314,-0.373683279290226,"TBX20","T-box 20",TRUE
+"220684_at",0.668227498775206,0.134400034372504,1.5538025866492,-4.82756872530779,0.561841128971675,"TBX21","T-box 21",TRUE
+"224017_at",0.664123571602771,0.132156046638301,1.56328831582345,-4.81468611322297,1.05683602216759,"TBX22","T-box 22",TRUE
+"228344_s_at",0.591331966259927,0.0688975948050484,-1.91196796618862,-4.30059442290259,-1.0218329966267,"TBX3","T-box 3",TRUE
+"229576_s_at",0.754513748034606,0.247846928955686,-1.18687528914126,-5.27591674768655,-1.36035695794834,"TBX3","T-box 3",TRUE
+"219682_s_at",0.841967750949524,0.434389289317593,-0.796155902280033,-5.63557929215086,-1.12629609736258,"TBX3","T-box 3",TRUE
+"229565_x_at",0.87579870142401,0.523539633657921,0.648164184262763,-5.73710587621629,0.320848434833285,"TBX3","T-box 3",TRUE
+"222917_s_at",0.89503392190686,0.572494308494316,0.572880223491757,-5.78108527738385,0.573550747416807,"TBX3","T-box 3",TRUE
+"225544_at",0.918041148686074,0.65160179845082,-0.457732426180603,-5.83814655144761,-0.561502341468126,"TBX3","T-box 3",TRUE
+"243234_at",0.990810941805126,0.956370347168339,-0.0553314197456822,-5.93819241483561,-0.0599254864602683,"TBX3","T-box 3",TRUE
+"220634_at",0.941952420964607,0.739227575920861,0.33708160758804,-5.88449243889713,0.137547454280512,"TBX4","T-box 4",TRUE
+"211886_s_at",0.75888724902379,0.256071529167625,1.16585157126889,-5.29849624745599,0.752403661118997,"TBX5","T-box 5",TRUE
+"1563018_at",0.972405051071295,0.866861149149402,0.169603256028105,-5.92568268506105,0.106210700171258,"TBX5","T-box 5",TRUE
+"207155_at",0.981587171772385,0.912501917570726,0.111145171360144,-5.93366845914572,0.0784015061300716,"TBX5","T-box 5",TRUE
+"240715_at",0.993225426079816,0.968271844680672,0.0402277495776271,-5.93889531094051,0.0320866286772805,"TBX5","T-box 5",TRUE
+"233965_at",0.64151921255818,0.111903202368367,1.65558122887107,-4.68616639798729,1.22249573050583,"TBX5-AS1","TBX5 antisense RNA 1",TRUE
+"233947_s_at",0.835513930382091,0.41482463875703,0.831026553202226,-5.60879929078717,0.821168722146301,"TBX5-AS1","TBX5 antisense RNA 1",TRUE
+"239919_at",0.980400508497125,0.908459642651849,-0.116303620648682,-5.93309735243327,-0.089480119136911,"TBX5-AS1","TBX5 antisense RNA 1",TRUE
+"233948_at",0.986342822130003,0.934714954939766,0.0828497466452688,-5.9363407931315,0.0320197972051632,"TBX5-AS1","TBX5 antisense RNA 1",TRUE
+"207684_at",0.640337040581689,0.111136127364041,1.65934424426865,-4.68080608444272,0.442151230450454,"TBX6","T-box 6",TRUE
+"215122_at",0.874162829001327,0.520026402584524,0.653709414614401,-5.73366013424292,0.316047463778879,"TBX6","T-box 6",TRUE
+"336_at",0.760237493549547,0.258388101065184,1.16002074569267,-5.30469597472854,0.778369672192431,"TBXA2R","thromboxane A2 receptor",TRUE
+"207555_s_at",0.762160327460673,0.261497312900499,1.15225539295663,-5.31291025796546,0.805137053331055,"TBXA2R","thromboxane A2 receptor",TRUE
+"207554_x_at",0.841550580403629,0.432835797210697,0.798888544452262,-5.63351959593444,0.267998635821376,"TBXA2R","thromboxane A2 receptor",TRUE
+"211590_x_at",0.897949253801113,0.586215381921628,0.55238349088132,-5.79214998320364,0.337095881256129,"TBXA2R","thromboxane A2 receptor",TRUE
+"208130_s_at",0.708473702007515,0.180511256067415,1.38277973874176,-5.04896521370217,0.958737903295905,"TBXAS1","thromboxane A synthase 1",TRUE
+"236345_at",0.975839239563742,0.884439646590611,0.147027901634107,-5.92916001939559,0.0949386353166952,"TBXAS1","thromboxane A synthase 1",TRUE
+"244272_s_at",0.963379172403332,0.833101552016342,-0.213224548881848,-5.91756352726915,-0.234164326010927,"TC2N","tandem C2 domains, nuclear",TRUE
+"234970_at",0.981944022360435,0.913487974115512,-0.109887313699102,-5.93380379636591,-0.175730250333602,"TC2N","tandem C2 domains, nuclear",TRUE
+"1553132_a_at",0.990810941805126,0.955103871638583,0.0569393620626851,-5.93810450114824,0.0960316096245659,"TC2N","tandem C2 domains, nuclear",TRUE
+"224030_s_at",0.737123149977386,0.222933871546239,-1.25393736846867,-5.2015560547665,-0.389033308793782,"TCAF1","TRPM8 channel associated factor 1",TRUE
+"1555906_s_at",0.789795896476304,0.318537088774297,1.02043182097977,-5.4448541132948,0.386566552795841,"TCAIM","T-cell activation inhibitor, mitochondrial",TRUE
+"226688_at",0.934081042629428,0.708140533169928,-0.379211746303326,-5.8698847276377,-0.177410795256842,"TCAIM","T-cell activation inhibitor, mitochondrial",TRUE
+"241666_at",0.955892698633978,0.799986775249379,0.256427402950656,-5.90770728954125,0.0933040256241098,"TCAIM","T-cell activation inhibitor, mitochondrial",TRUE
+"1555905_a_at",0.992126078367323,0.963386606574649,0.0464260266231743,-5.93863373111934,0.0211708021681929,"TCAIM","T-cell activation inhibitor, mitochondrial",TRUE
+"241663_at",0.994145854504594,0.973223698500385,0.033946598801093,-5.9391222186316,0.0139920022838744,"TCAIM","T-cell activation inhibitor, mitochondrial",TRUE
+"233320_at",0.822812833182588,0.387855417584135,0.880847773605877,-5.56867965248191,1.15589097977249,"TCAM1P","testicular cell adhesion molecule 1, pseudogene",TRUE
+"205766_at",0.685964914818381,0.154218211850892,-1.47523825892325,-4.9318638986574,-1.32106089757326,"TCAP","titin-cap",TRUE
+"1566207_at",0.812302873476553,0.360106612288871,0.934525798954796,-5.5230358273537,0.308767012865939,"TCEA1","transcription elongation factor A1",TRUE
+"216241_s_at",0.921772731877879,0.666592995806483,-0.436646999429355,-5.84724398224028,-0.160882827857193,"TCEA1","transcription elongation factor A1",TRUE
+"1566208_at",0.97689149311934,0.889491771549224,0.140554634432738,-5.9300658322279,0.0717397975190801,"TCEA1","transcription elongation factor A1",TRUE
+"238173_at",0.666864142145238,0.133616765929604,1.5570986185557,-4.82309937183578,1.01593120323075,"TCEA2","transcription elongation factor A2",TRUE
+"241428_x_at",0.69385705848116,0.163282184386284,-1.44202501481179,-4.97464214712237,-1.27954866530334,"TCEA2","transcription elongation factor A2",TRUE
+"203919_at",0.888830748858811,0.555851073529993,-0.598080346776611,-5.7669467806657,-0.409761942460843,"TCEA2","transcription elongation factor A2",TRUE
+"226388_at",0.743323328391634,0.233483667841762,-1.22487967130253,-5.23420991485065,-1.87287831955889,"TCEA3","transcription elongation factor A3",TRUE
+"241976_at",0.776955214137673,0.295607725702924,-1.07120457503827,-5.39572825947326,-0.61424802642409,"TCEA3","transcription elongation factor A3",TRUE
+"204045_at",0.771129599018869,0.279976107363943,-1.1074536313032,-5.35935101078779,-0.538858515530313,"TCEAL1","transcription elongation factor A like 1",TRUE
+"211276_at",0.980663666733946,0.909492684939702,0.114985027432378,-5.93324579912941,0.0890098744595926,"TCEAL2","transcription elongation factor A like 2",TRUE
+"227279_at",0.931370027472813,0.696734157137353,-0.39484286797175,-5.86403386138816,-0.239206662576297,"TCEAL3","transcription elongation factor A like 3",TRUE
+"202371_at",0.51470556386048,0.0350057740635389,-2.24591557924774,-3.74258531058405,-0.767998291789835,"TCEAL4","transcription elongation factor A like 4",TRUE
+"227705_at",0.895702554416613,0.576378655181339,0.567052911160967,-5.78427078752851,0.787071282988717,"TCEAL7","transcription elongation factor A like 7",TRUE
+"224819_at",0.82706053436911,0.395648477546005,0.866228406688217,-5.58067753424118,1.6374295602675,"TCEAL8","transcription elongation factor A like 8",TRUE
+"217975_at",0.626983082753167,0.0974493234137783,1.73048662203288,-4.57773968609016,3.75679692411353,"TCEAL9","transcription elongation factor A like 9",TRUE
+"1553815_a_at",0.61760967235709,0.0882927516057886,-1.78300583449017,-4.49959342382198,-0.67284599213114,"TCEANC","transcription elongation factor A N-terminal and central domain containing",TRUE
+"1563863_x_at",0.822512317941994,0.387539822999611,0.881443816196012,-5.56818653584066,0.319516511660294,"TCEANC","transcription elongation factor A N-terminal and central domain containing",TRUE
+"1563862_at",0.873301865850313,0.518320159894745,0.656409965541221,-5.73197184445815,0.282010439122008,"TCEANC","transcription elongation factor A N-terminal and central domain containing",TRUE
+"1562470_at",0.796378050779806,0.328952491101672,-0.998215333373948,-5.46567223435704,-0.607810389957479,"TCEANC2","transcription elongation factor A N-terminal and central domain containing 2",TRUE
+"238737_at",0.803583569469174,0.342114977861729,-0.970825088880887,-5.49076499312319,-0.445763788928072,"TCEANC2","transcription elongation factor A N-terminal and central domain containing 2",TRUE
+"202823_at",0.702421895253027,0.173846374331286,-1.40513878499862,-5.02121745311064,-0.607312827529272,"TCEB1","transcription elongation factor B subunit 1",TRUE
+"202824_s_at",0.833762648920706,0.411420155141367,-0.837199309828909,-5.60394678522505,-0.273558012684493,"TCEB1","transcription elongation factor B subunit 1",TRUE
+"200085_s_at",0.332429060350567,0.0081311660263122,-2.90720941910131,-2.49449972044678,-0.835054998245084,"TCEB2","transcription elongation factor B subunit 2",TRUE
+"213877_x_at",0.68747436517451,0.156292158810367,-1.46750193795969,-4.94189874089554,-0.833101154391992,"TCEB2","transcription elongation factor B subunit 2",TRUE
+"1570625_at",0.53333138995891,0.0421968025765124,2.1560482494205,-3.89837135731158,1.17148729773034,"TCEB3","transcription elongation factor B subunit 3",TRUE
+"202818_s_at",0.659870891937597,0.127651323573328,1.58274054623068,-4.78807548461,0.537736056263025,"TCEB3","transcription elongation factor B subunit 3",TRUE
+"213604_at",0.767011398042819,0.268168302837021,1.13582154445478,-5.33013407589818,0.316211915288495,"TCEB3","transcription elongation factor B subunit 3",TRUE
+"1570627_at",0.789062620647376,0.315293115194938,1.02745482657061,-5.43818695758846,0.517833189865238,"TCEB3","transcription elongation factor B subunit 3",TRUE
+"202819_s_at",0.822173415758858,0.386487171887203,0.88343417905747,-5.56653763207525,0.328302967679413,"TCEB3","transcription elongation factor B subunit 3",TRUE
+"213685_at",0.868361060481977,0.502941251232485,0.680977364008773,-5.71630699438269,0.387856632368246,"TCEB3-AS1","TCEB3 antisense RNA 1",TRUE
+"220844_at",0.866611803190887,0.497877331408923,0.689159078423269,-5.710967925637,0.360326530388524,"TCEB3B","transcription elongation factor B subunit 3B",TRUE
+"238838_at",0.915353407558177,0.642646826259856,0.470428425414791,-5.83246604871276,0.38695345797476,"TCERG1","transcription elongation regulator 1",TRUE
+"229706_at",0.925511384407886,0.678170250917825,-0.420500407204696,-5.85392573515958,-0.27806337936521,"TCERG1","transcription elongation regulator 1",TRUE
+"202396_at",0.94895689004559,0.768909506855284,0.297429370780967,-5.89668743154077,0.0757552448726688,"TCERG1","transcription elongation regulator 1",TRUE
+"231257_at",0.855405088766616,0.46824308360274,0.738027567708378,-5.67781381658113,0.393523856794278,"TCERG1L","transcription elongation regulator 1 like",TRUE
+"208986_at",0.632949074657601,0.103790923430265,-1.69653467656661,-4.6273332853024,-0.567058577108437,"TCF12","transcription factor 12",TRUE
+"215611_at",0.752913428584105,0.246172543077266,-1.1912189754456,-5.27120773564787,-0.884132359592408,"TCF12","transcription factor 12",TRUE
+"233678_at",0.872143246873812,0.515007167234895,0.661667671050856,-5.72866576407279,0.397214821609174,"TCF12","transcription factor 12",TRUE
+"238041_at",0.988139605576153,0.943405457408792,0.0717997421584469,-5.93717288335188,0.0341553879102552,"TCF12","transcription factor 12",TRUE
+"207306_at",0.897211098401297,0.583310400170803,0.556702785124992,-5.78985083078148,0.394437306542113,"TCF15","transcription factor 15 (basic helix-loop-helix)",TRUE
+"223274_at",0.88767000285873,0.552383010445413,0.603380472945405,-5.76389829549492,0.223895013903981,"TCF19","transcription factor 19",TRUE
+"212931_at",0.624331975868069,0.0957586806723556,1.73985575255372,-4.56392533696897,0.575131055156861,"TCF20","transcription factor 20",TRUE
+"215511_at",0.953564723226096,0.786214655412563,0.274538098436944,-5.90303949390486,0.0764130807122445,"TCF20","transcription factor 20",TRUE
+"204931_at",0.812302873476553,0.3595184744185,0.935692800741876,-5.52201588371645,0.827666609116933,"TCF21","transcription factor 21",TRUE
+"229529_at",0.820288124919738,0.378588255431878,0.898483863108494,-5.55395833673446,0.359604545799165,"TCF21","transcription factor 21",TRUE
+"242522_at",0.831487912516861,0.406121293041632,0.846871656609176,-5.5962757481995,1.02905768252993,"TCF24","transcription factor 24",TRUE
+"221495_s_at",0.594972224548427,0.0717261958067301,-1.89132658625944,-4.33310571591673,-0.763590838791815,"TCF25","transcription factor 25",TRUE
+"213311_s_at",0.716219454102037,0.191946185397428,-1.34589855409926,-5.09392569979248,-0.618072442662088,"TCF25","transcription factor 25",TRUE
+"214704_at",0.980434477155705,0.908630745370451,-0.116085207619889,-5.93312205809609,-0.0380670788934117,"TCF25","transcription factor 25",TRUE
+"209153_s_at",0.673366993714442,0.139524026140829,-1.53262318544631,-4.85610882810989,-0.723363566215786,"TCF3","transcription factor 3",TRUE
+"228052_x_at",0.677013732819214,0.14417225362857,1.5139567935182,-4.88100443884109,0.771206028212648,"TCF3","transcription factor 3",TRUE
+"216647_at",0.687545925823023,0.156385907303853,1.4671542048782,-4.94234878543705,0.86365744970717,"TCF3","transcription factor 3",TRUE
+"202648_at",0.734730148360473,0.219412724824702,-1.26386934151442,-5.19024420204348,-0.936815847407332,"TCF3","transcription factor 3",TRUE
+"215260_s_at",0.822010986888098,0.385420160702135,-0.885455306482758,-5.56485971324314,-0.331342160130159,"TCF3","transcription factor 3",TRUE
+"209152_s_at",0.822819707575556,0.388005314399872,-0.880564784077977,-5.56891366643047,-0.495957376613205,"TCF3","transcription factor 3",TRUE
+"213811_x_at",0.85334340854827,0.460938347250062,-0.750350287301756,-5.66911329075337,-0.404966907851454,"TCF3","transcription factor 3",TRUE
+"213730_x_at",0.854810562588402,0.466814698952919,-0.740428149096582,-5.67612958521298,-0.374826096893083,"TCF3","transcription factor 3",TRUE
+"210776_x_at",0.897710071620737,0.585336857552886,-0.553688607541491,-5.79145710485446,-0.282073678498509,"TCF3","transcription factor 3",TRUE
+"213731_s_at",0.902167005211393,0.600603142618921,0.531144637510565,-5.80320217142069,0.21879606779151,"TCF3","transcription factor 3",TRUE
+"209151_x_at",0.906507435035949,0.614180473223388,-0.511326552958132,-5.81313457643897,-0.234771358770006,"TCF3","transcription factor 3",TRUE
+"216645_at",0.909052380289506,0.622779855835066,0.49888145817007,-5.81918354947331,0.300956413255826,"TCF3","transcription factor 3",TRUE
+"213732_at",0.965992617204023,0.841090884647056,0.202866348358253,-5.91965837293628,0.064709833593243,"TCF3","transcription factor 3",TRUE
+"213809_x_at",0.97979222603145,0.903523442968078,0.122607231283289,-5.93236433940261,0.0715181783283025,"TCF3","transcription factor 3",TRUE
+"222146_s_at",0.109433493286707,0.00052739697300254,4.05027990757276,-0.0922026952062742,3.95237418665747,"TCF4","transcription factor 4",TRUE
+"212382_at",0.150552075411854,0.00107411243289852,3.75872090186115,-0.719618678579666,2.52541866930809,"TCF4","transcription factor 4",TRUE
+"212386_at",0.163850812837738,0.00130397034183204,3.67882860663405,-0.890559536232736,3.42993784710309,"TCF4","transcription factor 4",TRUE
+"212385_at",0.185392143728903,0.00179855283568485,3.54580679851198,-1.17379689468258,2.48552607354067,"TCF4","transcription factor 4",TRUE
+"212387_at",0.287796329902695,0.00490582861397919,3.12450402405734,-2.05430377882495,2.18833618455783,"TCF4","transcription factor 4",TRUE
+"213891_s_at",0.304824368772306,0.00602505124587738,3.0366430404427,-2.2336724828132,2.28485951286303,"TCF4","transcription factor 4",TRUE
+"203753_at",0.327864702134751,0.00771031494497487,2.93027431635423,-2.44833899403552,2.91173872008543,"TCF4","transcription factor 4",TRUE
+"228837_at",0.392585343378161,0.0133267564685869,2.68996416235946,-2.92169224383248,2.02257765060322,"TCF4","transcription factor 4",TRUE
+"237749_at",0.954054753819891,0.789180634553972,0.270630037376073,-5.90407350236525,0.177285234842409,"TCF4-AS1","TCF4 antisense RNA 1",TRUE
+"205255_x_at",0.3006142403197,0.00570163634588987,3.06029668689651,-2.18555771133068,1.12609732279622,"TCF7","transcription factor 7 (T-cell specific, HMG-box)",TRUE
+"205254_x_at",0.308861881799719,0.00647320880676769,3.00580922958137,-2.29619142239813,1.75145222238225,"TCF7","transcription factor 7 (T-cell specific, HMG-box)",TRUE
+"221016_s_at",0.677013732819214,0.143796067259937,1.51544897675062,-4.87902323813394,1.44231039045843,"TCF7L1","transcription factor 7 like 1",TRUE
+"212762_s_at",0.869600078542406,0.507025191759223,0.674412840974839,-5.72054665685329,0.497169731084718,"TCF7L2","transcription factor 7 like 2",TRUE
+"216037_x_at",0.879696065661189,0.534317817001233,0.631277810668206,-5.74742511864378,0.418627371631548,"TCF7L2","transcription factor 7 like 2",TRUE
+"212759_s_at",0.8920930097751,0.562753373846504,0.58758278967137,-5.77290795502723,0.516566946501919,"TCF7L2","transcription factor 7 like 2",TRUE
+"216035_x_at",0.896229101808264,0.579586264340469,0.562255760954665,-5.78686946166299,0.523123824020137,"TCF7L2","transcription factor 7 like 2",TRUE
+"236094_at",0.90126201032556,0.597923674449731,0.535081024426655,-5.80118557759066,0.431133996528876,"TCF7L2","transcription factor 7 like 2",TRUE
+"212761_at",0.908882763411412,0.621568463919953,0.500629724578425,-5.81834258047897,0.456398821977444,"TCF7L2","transcription factor 7 like 2",TRUE
+"216511_s_at",0.913123070637484,0.635236380699905,0.480994226661099,-5.82762269557845,0.342979011226198,"TCF7L2","transcription factor 7 like 2",TRUE
+"204849_at",0.909052380289506,0.622191328140415,-0.499730617177894,-5.81877543700537,-0.256198080248526,"TCFL5","transcription factor like 5",TRUE
+"235694_at",0.959862623175279,0.81843320767825,-0.232305305808973,-5.91343288011518,-0.0987190125507009,"TCFL5","transcription factor like 5",TRUE
+"213780_at",0.88698237223329,0.55107627892598,0.605382028806276,-5.76274030130145,0.428429536824559,"TCHH","trichohyalin",TRUE
+"223456_s_at",0.917102138198416,0.64948047638551,0.460732976842337,-5.83681776852567,0.18898863519909,"TCHP","trichoplein keratin filament binding",TRUE
+"223455_at",0.946727564264032,0.758495056221551,-0.311283431740497,-5.89259822971239,-0.0874024521125847,"TCHP","trichoplein keratin filament binding",TRUE
+"204158_s_at",0.687949239097856,0.157288034071172,1.46381662947476,-4.94666396139449,1.3945561475778,"TCIRG1","T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3",TRUE
+"39318_at",0.654728282657457,0.12366491037958,1.60043635934472,-4.76364445540009,0.916731002273829,"TCL1A","T-cell leukemia/lymphoma 1A",TRUE
+"209995_s_at",0.849935057946582,0.451507761216345,0.766433184537714,-5.65755278577891,0.503247710743704,"TCL1A","T-cell leukemia/lymphoma 1A",TRUE
+"206413_s_at",0.677013732819214,0.144277605009836,1.51353947782036,-4.88155823813868,0.7805020209503,"TCL1B","T-cell leukemia/lymphoma 1B",TRUE
+"221054_s_at",0.554387890519539,0.0507998780338891,-2.06518276116764,-4.0518121443074,-1.41960355982173,"TCL6","T-cell leukemia/lymphoma 6 (non-protein coding)",TRUE
+"207894_s_at",0.700061364939874,0.171659049711238,1.41262567623132,-5.01184411550058,0.788183174745307,"TCL6","T-cell leukemia/lymphoma 6 (non-protein coding)",TRUE
+"219840_s_at",0.728671251879936,0.210230802925098,-1.29035731522658,-5.15970369972312,-1.00829072971265,"TCL6","T-cell leukemia/lymphoma 6 (non-protein coding)",TRUE
+"239964_at",0.792013951867008,0.322860666835151,-1.01114891254272,-5.45360320699416,-0.692970665012639,"TCL6","T-cell leukemia/lymphoma 6 (non-protein coding)",TRUE
+"221624_at",0.849935057946582,0.452459349689732,-0.764801229017145,-5.65873641377101,-0.459672494925325,"TCL6","T-cell leukemia/lymphoma 6 (non-protein coding)",TRUE
+"219839_x_at",0.903925276836898,0.605920617565268,-0.523357778689773,-5.80714864996685,-0.172652357364169,"TCL6","T-cell leukemia/lymphoma 6 (non-protein coding)",TRUE
+"205513_at",0.941345931827527,0.737712662500188,0.339119693822533,-5.88382486902451,0.428323529027248,"TCN1","transcobalamin 1",TRUE
+"204043_at",0.614663663463974,0.0854713549406289,1.80013309676327,-4.47373937990895,0.7138247134772,"TCN2","transcobalamin 2",TRUE
+"202385_s_at",0.831370271469237,0.405589427023998,0.847846935000536,-5.59549770137242,0.284473760267716,"TCOF1","treacle ribosome biogenesis factor 1",TRUE
+"244686_at",0.874406257596174,0.520438024091419,-0.653058653781743,-5.73406596857214,-0.446208220355816,"TCOF1","treacle ribosome biogenesis factor 1",TRUE
+"202384_s_at",0.979302801466611,0.899991364705858,0.127120864978289,-5.9318157434317,0.0498344066754086,"TCOF1","treacle ribosome biogenesis factor 1",TRUE
+"238926_at",0.614110383129587,0.0850349563717809,1.80282569075241,-4.46965851698979,1.4597083537158,"TCONS_00029157","uncharacterized LOC101928399",TRUE
+"207503_at",0.899852720655724,0.593840548957632,0.54109603407855,-5.79807614427072,0.267161773738833,"TCP10","t-complex 10",TRUE
+"220826_at",0.62110896023334,0.0912344081133621,1.76564338438099,-4.52561814713757,0.635302091410374,"TCP10L","t-complex 10-like",TRUE
+"230394_at",0.834950917495714,0.413753757248802,-0.832964727825287,-5.60727927574033,-0.446143686162668,"TCP10L","t-complex 10-like",TRUE
+"220378_at",0.961212424803935,0.823054575836733,0.226284596917117,-5.9147742787311,0.140875029411037,"TCP11","t-complex 11",TRUE
+"205797_s_at",0.571677937624457,0.0595553144238147,1.98589422378562,-4.1821688348394,1.0941433820913,"TCP11L1","t-complex 11 like 1",TRUE
+"205796_at",0.610455440146151,0.0828725690427393,1.81634660678801,-4.44909971771312,0.945171699824807,"TCP11L1","t-complex 11 like 1",TRUE
+"233472_at",0.944850801239076,0.752113334641556,-0.319803510567102,-5.88999184891646,-0.125834690366135,"TCP11L1","t-complex 11 like 1",TRUE
+"1553861_at",0.813065886130395,0.362811798197716,-0.929174479729563,-5.52769782353017,-0.820725921514458,"TCP11L2","t-complex 11 like 2",TRUE
+"1565525_a_at",0.825648186672984,0.3931138545437,0.87096257713233,-5.57681269725651,0.701271622878857,"TCP11L2","t-complex 11 like 2",TRUE
+"1569206_at",0.852006864319744,0.457375280360519,0.756403288537218,-5.66478956673461,0.263180269033288,"TCP11L2","t-complex 11 like 2",TRUE
+"1565000_a_at",0.901020258602596,0.597285381852629,-0.536019996097436,-5.80070240683263,-0.216522671119555,"TCP11L2","t-complex 11 like 2",TRUE
+"1569207_s_at",0.960215182004783,0.819857802314207,0.230448421165097,-5.9138503265212,0.114137768437458,"TCP11L2","t-complex 11 like 2",TRUE
+"1565527_x_at",0.971216837324271,0.862715614006324,0.174939926238036,-5.92478839522119,0.0666808088592798,"TCP11L2","t-complex 11 like 2",TRUE
+"1559413_at",0.983326118527016,0.918722289853913,0.103213176580055,-5.9344961484551,0.0950458872171032,"TCP11L2","t-complex 11 like 2",TRUE
+"203054_s_at",0.643082025527735,0.113615106470087,-1.64726094991345,-4.69798540739674,-0.686126015547615,"TCTA","T-cell leukemia translocation altered",TRUE
+"237280_at",0.763995234099495,0.263978856284239,1.14610647119951,-5.31938025556251,0.33187492655592,"TCTE1","t-complex-associated-testis-expressed 1",TRUE
+"232258_at",0.542397752248982,0.0455480023836695,-2.11882829607282,-3.96173212379127,-1.34385327449358,"TCTE3","t-complex-associated-testis-expressed 3",TRUE
+"1554401_a_at",0.776983560547865,0.296051911349371,1.07019488462079,-5.3967260485633,0.484033716035857,"TCTE3","t-complex-associated-testis-expressed 3",TRUE
+"1554400_at",0.931582451098271,0.698345274140028,0.392629027103088,-5.8648766762448,0.213711615266451,"TCTE3","t-complex-associated-testis-expressed 3",TRUE
+"1557945_at",0.95279845708016,0.783985890509962,0.277477657704671,-5.90225203694698,0.0787828889000126,"TCTE3","t-complex-associated-testis-expressed 3",TRUE
+"1553635_s_at",0.997674669021782,0.988721557355756,-0.0142962820268135,-5.93958393348451,-0.0121191715651001,"TCTEX1D1","Tctex1 domain containing 1",TRUE
+"228606_at",0.871744769522775,0.51416038635109,-0.663014516453089,-5.72781479053805,-0.392277902960444,"TCTEX1D2","Tctex1 domain containing 2",TRUE
+"218584_at",0.709893941953691,0.182652607177782,-1.37573535939518,-5.05763091956287,-0.583905272153979,"TCTN1","tectonic family member 1",TRUE
+"1556864_at",0.772598033801268,0.283090719246178,1.10011647728854,-5.36680108401013,0.677534670247174,"TCTN1","tectonic family member 1",TRUE
+"206438_x_at",0.893600768892136,0.568903934881124,-0.578284388108407,-5.77810288672865,-0.166775539752614,"TCTN2","tectonic family member 2",TRUE
+"239928_at",0.910165867297668,0.626792334837495,0.493101895762316,-5.82194324733982,0.327324550482886,"TCTN2","tectonic family member 2",TRUE
+"212123_at",0.741874791795962,0.232406610587677,-1.22779993141479,-5.23095807794769,-0.348927323791546,"TCTN3","tectonic family member 3",TRUE
+"212121_at",0.936318756756998,0.715656187398421,-0.368964984820904,-5.87359371069954,-0.127975203634149,"TCTN3","tectonic family member 3",TRUE
+"203743_s_at",0.630132423960255,0.101305240175778,-1.70962641711167,-4.60829732395696,-0.731273137456808,"TDG","thymine DNA glycosylase",TRUE
+"206286_s_at",0.798428326317339,0.332925238683258,0.989869983188069,-5.47338485542257,0.557519268398551,"TDGF1P3///TDGF1","teratocarcinoma-derived growth factor 1 pseudogene 3///teratocarcinoma-derived growth factor 1",TRUE
+"1553494_at",0.658849897914525,0.126979259278737,-1.58569132356688,-4.78401633089048,-1.77261501871992,"TDH","L-threonine dehydrogenase (pseudogene)",TRUE
+"1555151_s_at",0.88162573969131,0.53845685094672,-0.624842166444535,-5.75128896160442,-0.475173751223899,"TDH","L-threonine dehydrogenase (pseudogene)",TRUE
+"1553493_a_at",0.990810941805126,0.954807492264584,-0.0573156732165155,-5.93808356294627,-0.0322863521384846,"TDH","L-threonine dehydrogenase (pseudogene)",TRUE
+"205943_at",0.544577979658206,0.0465490570133439,-2.10818874874995,-3.97971554337162,-2.02183773262509,"TDO2","tryptophan 2,3-dioxygenase",TRUE
+"231702_at",0.786851686785014,0.312718343815779,1.03306524699726,-5.43283116182042,0.676724758803989,"TDO2","tryptophan 2,3-dioxygenase",TRUE
+"219715_s_at",0.620223198657182,0.0902125128073144,-1.77161958407826,-4.51668142148377,-0.644013397394229,"TDP1","tyrosyl-DNA phosphodiesterase 1",TRUE
+"226044_at",0.743553048228796,0.233974702142536,-1.22355170121929,-5.23568645448883,-0.450808359717129,"TDP1","tyrosyl-DNA phosphodiesterase 1",TRUE
+"240822_at",0.867834927246481,0.500974131664587,-0.684150045413727,-5.71424385951951,-0.594167783868635,"TDP1","tyrosyl-DNA phosphodiesterase 1",TRUE
+"202266_at",0.947938416246738,0.763118598831279,0.305125346682948,-5.89443864218367,0.0973840111525082,"TDP2","tyrosyl-DNA phosphodiesterase 2",TRUE
+"221018_s_at",0.854163696308241,0.463878324691798,-0.745376824038057,-5.67264126593496,-0.674500468842304,"TDRD1","tudor domain containing 1",TRUE
+"231371_at",0.799008022536007,0.333522058353899,0.988622227329939,-5.47453295052676,0.479695692695924,"TDRD10","tudor domain containing 10",TRUE
+"215356_at",0.841247691968787,0.431388834504248,-0.801439260307789,-5.63159103825581,-1.25008839278601,"TDRD12","tudor domain containing 12",TRUE
+"208089_s_at",0.739065087110387,0.225713924546305,-1.24618020710551,-5.21033767749731,-0.503003785461369,"TDRD3","tudor domain containing 3",TRUE
+"1569069_s_at",0.817857130700434,0.370663591841265,-0.913791689718607,-5.54096182410273,-0.34575968290282,"TDRD3","tudor domain containing 3",TRUE
+"214028_x_at",0.975196332002567,0.87950180692323,-0.153360955736166,-5.92823444766035,-0.0734994666089603,"TDRD3","tudor domain containing 3",TRUE
+"231104_at",0.872668627020452,0.516530198482464,-0.659248307236839,-5.7301902174823,-0.810280803661068,"TDRD5","tudor domain containing 5",TRUE
+"232692_at",0.622489181861932,0.093108669945439,1.75483025483572,-4.54173151632752,1.54856416700932,"TDRD6","tudor domain containing 6",TRUE
+"213361_at",0.819780516863333,0.377463150945257,0.900644226510845,-5.55213645892024,0.4015267159927,"TDRD7","tudor domain containing 7",TRUE
+"228285_at",0.91269009113888,0.63372570376601,0.483154940301596,-5.82661926841192,0.403255739069807,"TDRD9","tudor domain containing 9",TRUE
+"230236_at",0.841738620491136,0.433589218768127,0.797562496244713,-5.63451991762388,0.360306710577485,"TDRG1","testis development related 1 (non-protein coding)",TRUE
+"221053_s_at",0.777826511138126,0.296946918463395,1.06816370617483,-5.3987307346918,0.421671891361243,"TDRKH","tudor and KH domain containing",TRUE
+"221052_at",0.98529096111871,0.927107248981873,0.0925316074049652,-5.93551405859848,0.0295519310605572,"TDRKH","tudor and KH domain containing",TRUE
+"223530_at",0.990810941805126,0.953743653837874,0.05866649289167,-5.93800726665127,0.0320281743914084,"TDRKH","tudor and KH domain containing",TRUE
+"226778_at",0.861659105448003,0.48348610657621,0.712673728653632,-5.69528456643598,0.779965179759588,"TDRP","testis development related protein",TRUE
+"230903_s_at",0.903919439852106,0.605581541841989,0.523853336151268,-5.80689918607028,0.708879873922871,"TDRP","testis development related protein",TRUE
+"242387_at",0.973433731874338,0.871713903227913,0.163362549154274,-5.92669342315125,0.176047181476272,"TDRP","testis development related protein",TRUE
+"214600_at",0.739340500562926,0.226452187192547,1.2441325022709,-5.21264800342917,0.670767141201773,"TEAD1","TEA domain transcription factor 1",TRUE
+"224955_at",0.782206338814045,0.304143478606274,1.05198809813708,-5.41457351158733,0.966008188682096,"TEAD1","TEA domain transcription factor 1",TRUE
+"1553322_s_at",0.79476249846508,0.326884529699876,1.00258703531926,-5.46160852484399,0.810867915242272,"TEAD1","TEA domain transcription factor 1",TRUE
+"238322_s_at",0.787983178144695,0.314088204792017,-1.03007629771696,-5.4356877345926,-0.558888417476421,"TEAD2","TEA domain transcription factor 2",TRUE
+"243766_s_at",0.870852305833096,0.510574753371523,0.668731364788575,-5.72418427671287,0.561511295480295,"TEAD2","TEA domain transcription factor 2",TRUE
+"226408_at",0.889212046119563,0.556751641057357,-0.596706866718702,-5.76773252951573,-0.446332344347631,"TEAD2","TEA domain transcription factor 2",TRUE
+"238323_at",0.987977863996795,0.942598854147175,0.0728249338796845,-5.93710068566328,0.0797664663292572,"TEAD2","TEA domain transcription factor 2",TRUE
+"209454_s_at",0.813318838397609,0.363155972598095,0.928495562345417,-5.52828752730459,0.283673244343836,"TEAD3","TEA domain transcription factor 3",TRUE
+"41037_at",0.980001024522674,0.905057993693081,0.120647051144672,-5.93259641642967,0.0564112237164665,"TEAD4","TEA domain transcription factor 4",TRUE
+"204281_at",0.992342196993659,0.964264260649526,0.0453123492943888,-5.93868348782697,0.0221836584540718,"TEAD4","TEA domain transcription factor 4",TRUE
+"206301_at",0.946416600885596,0.757860294832614,0.312129823231512,-5.89234242831003,0.161205835575067,"TEC","tec protein tyrosine kinase",TRUE
+"227580_s_at",0.862800800218883,0.486648218892984,-0.707472793696671,-5.69879658398685,-0.268108802353307,"TECPR1","tectonin beta-propeller repeat containing 1",TRUE
+"227581_at",0.975265330414469,0.880114425439139,-0.152574894771085,-5.92835144669858,-0.0393490201655968,"TECPR1","tectonin beta-propeller repeat containing 1",TRUE
+"231912_s_at",0.992342196993659,0.96390882240339,0.0457633666665776,-5.93866348286578,0.0119954280661148,"TECPR1","tectonin beta-propeller repeat containing 1",TRUE
+"204307_at",0.818870377846293,0.372808805584818,0.909626653736741,-5.54451805830509,0.575614387082354,"TECPR2","tectonin beta-propeller repeat containing 2",TRUE
+"204308_s_at",0.891857030679378,0.561849539363887,-0.588953601455881,-5.77213531504082,-0.229225301754319,"TECPR2","tectonin beta-propeller repeat containing 2",TRUE
+"1569392_at",0.729273475042162,0.21175940904928,1.28588651383211,-5.16489636940391,0.549804875432339,"TECR","trans-2,3-enoyl-CoA reductase",TRUE
+"208336_s_at",0.774230543658252,0.28749339061827,1.08984404329202,-5.37715759165248,0.387401389487124,"TECR","trans-2,3-enoyl-CoA reductase",TRUE
+"241961_at",0.939389447806415,0.728626021080465,-0.351375533802067,-5.87972660955536,-0.322483305768959,"TECRL","trans-2,3-enoyl-CoA reductase-like",TRUE
+"221296_at",0.739340500562926,0.226783252334906,1.24321588619608,-5.21368111823526,0.812899225784968,"TECTA","tectorin alpha",TRUE
+"236904_x_at",0.933690722965564,0.706488323726069,0.381469866425023,-5.86905388963425,0.293696323827978,"TECTA","tectorin alpha",TRUE
+"1553656_at",0.758349492775124,0.255326482463875,-1.16773517581646,-5.29648765146046,-0.731322550533815,"TECTB","tectorin beta",TRUE
+"1552940_at",0.998870448604467,0.995521411154329,-0.005676781029204,-5.93966778474139,-0.00424150786218291,"TEDDM1","transmembrane epididymal protein 1",TRUE
+"225840_at",0.904832003218088,0.609635302658868,0.517937430103181,-5.8098622403813,0.235556381641887,"TEF","TEF, PAR bZIP transcription factor",TRUE
+"215673_at",0.971216837324271,0.862515388121396,-0.175197813369842,-5.92474448023989,-0.133323568292613,"TEF","TEF, PAR bZIP transcription factor",TRUE
+"210167_s_at",0.986944270343822,0.939874721832578,-0.0762879004616443,-5.93684924693265,-0.0613321257655652,"TEF","TEF, PAR bZIP transcription factor",TRUE
+"215675_at",0.997352239065314,0.986550495651067,0.0170485236855569,-5.93954191578981,0.0104147582792158,"TEF","TEF, PAR bZIP transcription factor",TRUE
+"219146_at",0.903021267024792,0.602994397424741,-0.527638822476086,-5.80498598501348,-0.206433746765528,"TEFM","transcription elongation factor, mitochondrial",TRUE
+"238295_at",0.91994485246627,0.659238701180057,0.44696523949822,-5.84284468810658,0.19377516450493,"TEFM","transcription elongation factor, mitochondrial",TRUE
+"206702_at",0.599670629792675,0.0759747778833538,1.86162334978454,-4.37945480442254,1.60518286931599,"TEK","TEK receptor tyrosine kinase",TRUE
+"217711_at",0.909052380289506,0.622670752796413,-0.499038849738555,-5.81910795700818,-0.308079765536906,"TEK","TEK receptor tyrosine kinase",TRUE
+"239216_at",0.813631136157676,0.364427600061845,0.925990878929532,-5.53045965095317,0.361036701951779,"TEKT1","tektin 1",TRUE
+"210323_at",0.690823350461169,0.160398099921584,1.45242791037216,-4.96132847145955,0.932572443796418,"TEKT2","tektin 2",TRUE
+"223867_at",0.899046682581382,0.589105686112099,-0.548096538333683,-5.79441472516868,-0.26050055722421,"TEKT3","tektin 3",TRUE
+"226558_at",0.678611044120554,0.146209688768131,1.50593003735349,-4.89163495015692,1.48422764980008,"TEKT4P2///MAFIP///LOC389834","tektin 4 pseudogene 2///MAFF interacting protein (pseudogene)///ankyrin repeat domain 57 pseudogene",TRUE
+"1553488_at",0.765419357517701,0.265723362140713,1.14180928943053,-5.32388373401755,0.428927652931517,"TEKT5","tektin 5",TRUE
+"1553489_a_at",0.865345395265289,0.495125081484217,0.693625700073541,-5.7080274828023,0.314515824543757,"TEKT5","tektin 5",TRUE
+"34260_at",0.683017520100356,0.151508634782958,-1.48547397320572,-4.91852162451981,-0.451989790934414,"TELO2","telomere maintenance 2",TRUE
+"209528_s_at",0.845724545411341,0.443638265765756,-0.780009869997825,-5.64761354822695,-0.234973449453326,"TELO2","telomere maintenance 2",TRUE
+"229468_at",0.731054546207485,0.214039992990834,1.27926246272675,-5.17256174673959,0.406904814269904,"TEN1-CDK3///CDK3","TEN1-CDK3 readthrough (NMD candidate)///cyclin dependent kinase 3",TRUE
+"207188_at",0.965707350334601,0.839843050773844,0.204482644982008,-5.91933833212321,0.146517676825425,"TEN1-CDK3///CDK3","TEN1-CDK3 readthrough (NMD candidate)///cyclin dependent kinase 3",TRUE
+"226396_at",0.77204612088057,0.282202821476622,1.10220212679029,-5.36468781217227,0.812625841604095,"TEN1-CDK3///TEN1","TEN1-CDK3 readthrough (NMD candidate)///TEN1 CST complex subunit",TRUE
+"1553007_a_at",0.675662829199842,0.142275375447239,1.52151376855892,-4.87095487537905,0.963416696549803,"TENM1","teneurin transmembrane protein 1",TRUE
+"205728_at",0.941400961503247,0.737924938868511,0.338834020115129,-5.88391868053931,0.515955347385967,"TENM1","teneurin transmembrane protein 1",TRUE
+"231867_at",0.594005743610726,0.0709368491384872,1.89701394526191,-4.32417240293693,2.58022062488937,"TENM2","teneurin transmembrane protein 2",TRUE
+"219523_s_at",0.26338132901877,0.00396938665041548,-3.21441542044328,-1.86901760472221,-3.56703324490988,"TENM3","teneurin transmembrane protein 3",TRUE
+"1559661_at",0.776815407888638,0.29431961777437,-1.07413876265476,-5.39282388168472,-0.994027153916484,"TENM3","teneurin transmembrane protein 3",TRUE
+"227050_at",0.959075430908792,0.814446680513858,0.237505999477356,-5.91224597465689,0.224293412936825,"TENM3","teneurin transmembrane protein 3",TRUE
+"213273_at",0.853768202875953,0.462531154977643,-0.747653446512022,-5.67102907982718,-0.582565232541591,"TENM4","teneurin transmembrane protein 4",TRUE
+"205727_at",0.797960028258877,0.332024814983114,0.991755400792911,-5.47164753204151,0.979562191860784,"TEP1","telomerase associated protein 1",TRUE
+"228670_at",0.935094665155941,0.71138858377294,0.374778380132535,-5.87150175846787,0.168349690288169,"TEP1","telomerase associated protein 1",TRUE
+"240119_at",0.415784938105573,0.0169203747102862,2.58288910569143,-3.12663392484405,1.33025278934802,"TEPP","testis, prostate and placenta expressed",TRUE
+"239681_at",0.597654932724127,0.0748244649363563,-1.86951944094037,-4.36718419546884,-1.14145361681012,"TEPSIN","TEPSIN, adaptor related protein complex 4 accessory protein",TRUE
+"227668_at",0.704092960947689,0.17589768182139,1.39818548818962,-5.02988595897772,0.472702680169936,"TEPSIN","TEPSIN, adaptor related protein complex 4 accessory protein",TRUE
+"236737_at",0.869971289491322,0.508072838730683,0.672733650960318,-5.72162484116184,0.435365395959607,"TEPSIN","TEPSIN, adaptor related protein complex 4 accessory protein",TRUE
+"238980_x_at",0.952082954955992,0.780817044163488,-0.28166141819577,-5.9011169256214,-0.0869396089643892,"TEPSIN","TEPSIN, adaptor related protein complex 4 accessory protein",TRUE
+"1553451_at",0.820802653782978,0.381705135346795,0.892520963598134,-5.55896596439189,0.473183459807114,"TERB1","telomere repeat binding bouquet formation protein 1",TRUE
+"240876_x_at",0.955735662836499,0.797807445264882,-0.259287290105406,-5.90699122237972,-0.239812731290611,"TERB2","telomere repeat binding bouquet formation protein 2",TRUE
+"203449_s_at",0.820288124919738,0.37836629708539,-0.898909720265287,-5.55359952298662,-0.389501330850367,"TERF1","telomeric repeat binding factor 1",TRUE
+"203448_s_at",0.934612165247339,0.709788419993545,-0.376961532272109,-5.87070781724638,-0.144666671392633,"TERF1","telomeric repeat binding factor 1",TRUE
+"235872_at",0.888819796590582,0.555774507651373,-0.598197172988066,-5.76687986547736,-0.169796967038053,"TERF2","telomeric repeat binding factor 2",TRUE
+"1555183_at",0.89205696974366,0.562413534722782,-0.588098077469078,-5.77261772410475,-0.527667100657744,"TERF2","telomeric repeat binding factor 2",TRUE
+"229790_at",0.936143408699214,0.715272623357902,0.369486949229335,-5.87340720036363,0.124433746210277,"TERF2","telomeric repeat binding factor 2",TRUE
+"1555185_x_at",0.95877806139143,0.813314807501249,0.238983819269091,-5.91190393723129,0.0961664388677388,"TERF2","telomeric repeat binding factor 2",TRUE
+"203611_at",0.985498770484702,0.930091952119109,-0.0887321309572687,-5.93584936971851,-0.0262301283308748,"TERF2","telomeric repeat binding factor 2",TRUE
+"201174_s_at",0.315093142651413,0.0067805036340312,-2.98583051998675,-2.33657557692544,-1.00949068647184,"TERF2IP","TERF2 interacting protein",TRUE
+"207199_at",0.682744111897512,0.150704499044426,1.48854032758741,-4.91451015666551,0.994485688498018,"TERT","telomerase reverse transcriptase",TRUE
+"1555271_a_at",0.789378278298554,0.315948776538644,1.02603128757682,-5.4395417038799,0.524695417988209,"TERT","telomerase reverse transcriptase",TRUE
+"244870_at",0.595019326272843,0.0719573440387021,1.88967150212308,-4.33570188092751,1.24643137671446,"TES","testin LIM domain protein",TRUE
+"202720_at",0.776955214137673,0.295596769070349,1.07122949457152,-5.39570362302586,1.17730032994077,"TES","testin LIM domain protein",TRUE
+"202719_s_at",0.832345904876127,0.408523134107926,0.842477535476589,-5.59977087706867,1.06173463111534,"TES","testin LIM domain protein",TRUE
+"218872_at",0.891420607788025,0.561020267288266,0.590212329755323,-5.77142431608839,0.585035101492904,"TESC","tescalcin",TRUE
+"240553_at",0.891859820584895,0.561867608962903,-0.588926184823564,-5.77215078512797,-0.377033911798395,"TESC","tescalcin",TRUE
+"204106_at",0.864829185767069,0.492738044057957,-0.697511111672498,-5.70545491360516,-0.322853980619966,"TESK1","testis-specific kinase 1",TRUE
+"205486_at",0.984798640722849,0.925304774203381,-0.0948267995946693,-5.93530469855261,-0.0596115106640251,"TESK2","testis-specific kinase 2",TRUE
+"238246_at",0.990810941805126,0.956442105408734,0.0552403185839046,-5.93819732040397,0.0497852699134196,"TESMIN","testis expressed metallothionein like protein",TRUE
+"219786_at",0.999886947266554,0.99971554241326,0.000360558751824831,-5.93968341742963,0.000248109339715086,"TESMIN","testis expressed metallothionein like protein",TRUE
+"222920_s_at",0.849935057946582,0.452406861309768,-0.764891191492653,-5.65867122769244,-0.264809072286437,"TESPA1","thymocyte expressed, positive selection associated 1",TRUE
+"219724_s_at",0.951879312464239,0.779432054848214,-0.283491599321986,-5.90061507238477,-0.0947727153082729,"TESPA1","thymocyte expressed, positive selection associated 1",TRUE
+"228906_at",0.900750978800947,0.596269253590113,-0.537515796683115,-5.79993100450682,-0.28348065175833,"TET1","tet methylcytosine dioxygenase 1",TRUE
+"214862_x_at",0.998347572104896,0.99320962262046,-0.00860712332943873,-5.93964739792408,-0.00498975948499947,"TET1","tet methylcytosine dioxygenase 1",TRUE
+"235461_at",0.722990310174628,0.199752933250991,1.32170083899761,-5.12287071208931,0.940350652045002,"TET2","tet methylcytosine dioxygenase 2",TRUE
+"227624_at",0.729789891627758,0.212106079838596,-1.28487605665242,-5.1660678532358,-0.454527673333251,"TET2","tet methylcytosine dioxygenase 2",TRUE
+"1569385_s_at",0.998870448604467,0.995138097496499,-0.0061626517869945,-5.93966498294752,-0.00386174135311368,"TET2","tet methylcytosine dioxygenase 2",TRUE
+"214754_at",0.548924465506383,0.0484970725506982,-2.08806117411003,-4.013577355645,-0.79216465713831,"TET3","tet methylcytosine dioxygenase 3",TRUE
+"1554641_a_at",0.635626505801859,0.106622717764177,-1.68194050279837,-4.64842388743114,-1.10519154041535,"TET3","tet methylcytosine dioxygenase 3",TRUE
+"235542_at",0.725583196024696,0.20446367537439,-1.30745481556478,-5.13970452378569,-0.6118388794336,"TET3","tet methylcytosine dioxygenase 3",TRUE
+"218104_at",0.891444650197327,0.561143529292647,0.590025173049976,-5.77153012538148,0.219246509160669,"TEX10","testis expressed 10",TRUE
+"1558702_at",0.945272089973488,0.75286009958557,0.318805286820693,-5.8903008204429,0.0911442214198539,"TEX10","testis expressed 10",TRUE
+"223906_s_at",0.595019326272843,0.0719096722742315,1.89001246366082,-4.33516717888119,0.946094837416311,"TEX101","testis expressed 101",TRUE
+"234296_s_at",0.49862202680795,0.0312716036565974,2.29945406251011,-3.64796524611227,1.08177812830307,"TEX11","testis expressed 11",TRUE
+"221259_s_at",0.820611742812032,0.380887736616814,0.89408162563514,-5.55765830545826,0.273378656058745,"TEX11","testis expressed 11",TRUE
+"233514_x_at",0.87927534655779,0.533199210496945,-0.63302170059555,-5.74637155821608,-0.23476393017138,"TEX11","testis expressed 11",TRUE
+"221438_s_at",0.935305440291053,0.71226909222494,-0.373577867117391,-5.87193640720643,-0.241693191116844,"TEX12","testis expressed 12",TRUE
+"236848_s_at",0.894136768148992,0.570415920860299,0.576006463774692,-5.77936330881816,0.203040783332796,"TEX13A","testis expressed 13A",TRUE
+"221429_x_at",0.917102138198416,0.649248638905487,0.461061164422693,-5.83667191577248,0.353559530386984,"TEX13A","testis expressed 13A",TRUE
+"221034_s_at",0.635916735157933,0.107194331688536,1.67903450451714,-4.65260701788609,1.08899647591666,"TEX13B","testis expressed 13B",TRUE
+"221035_s_at",0.904381089098038,0.607881427372251,-0.52049466049897,-5.80858544268209,-0.645878529089526,"TEX14","testis expressed 14, intercellular bridge forming factor",TRUE
+"232760_at",0.622434989367596,0.0923893174474779,1.7589581156504,-4.5355889110261,1.81712408070083,"TEX15","testis expressed 15",TRUE
+"221448_s_at",0.930065981387326,0.691275249844009,-0.40235900167598,-5.8611376310122,-0.206737514406449,"TEX15","testis expressed 15",TRUE
+"241367_at",0.682125064335234,0.149655397221419,-1.49256089374785,-4.90924028705163,-0.783673200826317,"TEX19","testis expressed 19",TRUE
+"218099_at",0.956398858120188,0.802400074089223,-0.253263030502914,-5.90849039753954,-0.100031579953651,"TEX2","testis expressed 2",TRUE
+"1558581_at",0.936497309685708,0.716662512296751,-0.367596046222272,-5.87408162887065,-0.135941162101783,"TEX22","testis expressed 22",TRUE
+"243884_at",0.720174137377026,0.196248275679567,1.33247051035288,-5.11004267621014,0.931812410650727,"TEX26","testis expressed 26",TRUE
+"1560842_a_at",0.726480797733202,0.205387694582726,1.3046904627736,-5.14295314563415,0.97501643794823,"TEX26-AS1","TEX26 antisense RNA 1",TRUE
+"1565763_at",0.791211889207316,0.321528052118589,1.01400079088898,-5.45092302527577,0.406977435113439,"TEX26-AS1","TEX26 antisense RNA 1",TRUE
+"1562631_at",0.986342822130003,0.93359189400118,0.0842784642232241,-5.9362245318121,0.0504268202313378,"TEX26-AS1","TEX26 antisense RNA 1",TRUE
+"212083_at",0.832605695407954,0.409366370442737,-0.840938753893719,-5.6009908269278,-0.229032659923787,"TEX261","testis expressed 261",TRUE
+"212084_at",0.987360737469712,0.94068277074306,0.075260596212332,-5.93692505506418,0.0231090207527913,"TEX261","testis expressed 261",TRUE
+"233350_s_at",0.35126806165666,0.00929647709587904,-2.84883882813367,-2.61066271124146,-1.17236598217868,"TEX264","testis expressed 264",TRUE
+"218548_x_at",0.446963972064621,0.0211686283591956,-2.48095880988906,-3.31784847958347,-0.949097318647164,"TEX264","testis expressed 264",TRUE
+"207364_at",0.986342822130003,0.935435930719363,0.0819326405988129,-5.93641437545916,0.0302055958570597,"TEX28","testis expressed 28",TRUE
+"236853_at",0.954449231029359,0.791001243657557,-0.26823328426409,-5.90470036143832,-0.126573436473461,"TEX29","testis expressed 29",TRUE
+"213346_at",0.552420073963858,0.0500547989987968,2.07248163187231,-4.03964382711729,0.833402270571648,"TEX30","testis expressed 30",TRUE
+"231617_at",0.979347742195592,0.900402989282358,-0.126594713574733,-5.9318807124599,-0.116929274010442,"TEX33","testis expressed 33",TRUE
+"223938_at",0.88060408451642,0.536058345780508,0.628568265121158,-5.74905652511954,0.38796123775977,"TEX35","testis expressed 35",TRUE
+"244789_at",0.813454382987859,0.364049662502605,0.926734679376458,-5.52981517226778,0.65265234156675,"TEX36","testis expressed 36",TRUE
+"1556133_s_at",0.901788521024914,0.599724415418141,0.532434630425906,-5.80254290959737,0.353613909655245,"TEX36-AS1","TEX36 antisense RNA 1",TRUE
+"241430_at",0.837067957688307,0.419503250823196,0.822595616873343,-5.61537269938887,0.308441558224898,"TEX37","testis expressed 37",TRUE
+"230969_at",0.824246019586314,0.391670321127842,0.87366764597781,-5.57459557225747,0.444552367863852,"TEX38","testis expressed 38",TRUE
+"219883_at",0.645803111489595,0.117020314095532,1.63101953824603,-4.72092489405278,0.397627348630047,"TEX40","testis expressed 40",TRUE
+"1562475_at",0.889318152488679,0.556872000234566,0.596523391398598,-5.76783736104426,0.52180773308014,"TEX41","testis expressed 41 (non-protein coding)",TRUE
+"237428_at",0.865261053080938,0.494547927000993,-0.694564158329614,-5.70740737657888,-0.391420228252266,"TEX43","testis expressed 43",TRUE
+"243198_at",0.774011928861764,0.285786383052549,-1.09381329806657,-5.37316610314071,-1.13110067371995,"TEX9","testis expressed 9",TRUE
+"1566606_a_at",0.805840793982593,0.346086939860864,-0.962701941628622,-5.49808434893071,-0.634036037167527,"TEX9","testis expressed 9",TRUE
+"1562259_at",0.875891766935648,0.523917043362843,-0.647569703683646,-5.73747360699145,-0.258016841253551,"TEX9","testis expressed 9",TRUE
+"1566605_at",0.897775788064796,0.585446693144257,0.55352538503898,-5.791543845524,0.458512882445562,"TEX9","testis expressed 9",TRUE
+"203400_s_at",0.753209533292557,0.246468619298347,1.19044928907943,-5.27204324908095,1.91721377239121,"TF","transferrin",TRUE
+"214064_at",0.75536453281804,0.249425720630944,1.18279965311586,-5.28032152419566,1.02184180758537,"TF","transferrin",TRUE
+"214063_s_at",0.843600852223733,0.438892240155229,0.788268960362336,-5.64148673766131,1.16127003168033,"TF","transferrin",TRUE
+"220109_at",0.994701128358967,0.975380450365304,-0.0312113319132471,-5.93920902068344,-0.0410016671777442,"TF","transferrin",TRUE
+"208541_x_at",0.89316156038085,0.567207690153755,0.580843595713942,-5.7766810798257,0.231838835166437,"TFAM","transcription factor A, mitochondrial",TRUE
+"238443_at",0.919406408954167,0.657576373293332,0.449304328220509,-5.84183337741336,0.204810728642126,"TFAM","transcription factor A, mitochondrial",TRUE
+"203176_s_at",0.976589025744684,0.888597649582715,-0.141699813397874,-5.92990854890747,-0.0492994679123981,"TFAM","transcription factor A, mitochondrial",TRUE
+"203177_x_at",0.980267546812478,0.90809158744244,0.116773463657278,-5.93304404921988,0.0429583766090769,"TFAM","transcription factor A, mitochondrial",TRUE
+"210669_at",0.811844013927892,0.35601499993985,0.942671230498571,-5.51589244364415,0.499346955075886,"TFAP2A","transcription factor AP-2 alpha",TRUE
+"204653_at",0.871090069138449,0.511580637629123,0.667125353831568,-5.72520719812756,0.438305570391824,"TFAP2A","transcription factor AP-2 alpha",TRUE
+"204654_s_at",0.888830748858811,0.5558170783182,0.598132216519647,-5.76691707250758,0.391611732370196,"TFAP2A","transcription factor AP-2 alpha",TRUE
+"1560503_a_at",0.914588178928864,0.640454277213524,-0.473548847721987,-5.83104660296674,-0.169372208107253,"TFAP2A-AS1","TFAP2A antisense RNA 1",TRUE
+"1557070_at",0.932633693661011,0.702661119069974,-0.386708403210664,-5.86710772899322,-0.246711717509021,"TFAP2A-AS1","TFAP2A antisense RNA 1",TRUE
+"214451_at",0.889389445320988,0.557137077010842,-0.596119381639144,-5.76806808860194,-1.26195033570568,"TFAP2B","transcription factor AP-2 beta",TRUE
+"1553394_a_at",0.912906062613339,0.634692447274256,-0.481771943809419,-5.82726203328643,-0.736602432813776,"TFAP2B","transcription factor AP-2 beta",TRUE
+"215686_x_at",0.983499244849441,0.919605521617521,-0.102087473088561,-5.9346086553313,-0.134528800366046,"TFAP2B","transcription factor AP-2 beta",TRUE
+"205287_s_at",0.68806049531767,0.157465437947673,-1.46316211820616,-4.9475092497459,-1.82200290675366,"TFAP2C","transcription factor AP-2 gamma",TRUE
+"205286_at",0.828381235576304,0.398167175985175,-0.861543341792808,-5.58448299491054,-1.0463341394775,"TFAP2C","transcription factor AP-2 gamma",TRUE
+"233987_at",0.904832003218088,0.610158207562035,0.517175687932873,-5.81024138559983,0.325291105945821,"TFAP2D","transcription factor AP-2 delta",TRUE
+"1555348_at",0.62110896023334,0.0915951031217622,1.76354771270263,-4.52874673477106,0.621645129092857,"TFAP2E","transcription factor AP-2 epsilon",TRUE
+"205688_at",0.727286289873957,0.207488691586237,1.29844074687462,-5.15027623072995,0.777086708843033,"TFAP4","transcription factor AP-4",TRUE
+"232022_at",0.555180272174837,0.0514165618244953,2.05921376295332,-4.06174257229797,0.648736646829922,"TFB1M","transcription factor B1, mitochondrial",TRUE
+"219169_s_at",0.603702127972549,0.0777992535223098,1.84931072088793,-4.39851523559093,0.715655236372305,"TFB1M","transcription factor B1, mitochondrial",TRUE
+"228075_x_at",0.643688366500038,0.114692493213413,1.6420785306789,-4.70532403278115,0.591573336487505,"TFB1M","transcription factor B1, mitochondrial",TRUE
+"234301_s_at",0.992511588832933,0.965115564995507,0.0442321639226638,-5.93873059429714,0.0346263137943881,"TFB1M","transcription factor B1, mitochondrial",TRUE
+"218605_at",0.758966211371161,0.256491851562649,-1.164790719679,-5.29962624405933,-0.40940238720539,"TFB2M","transcription factor B2, mitochondrial",TRUE
+"1566931_at",0.916008366263392,0.645506812969057,0.466365216226149,-5.83430058798672,0.181070407426925,"TFB2M","transcription factor B2, mitochondrial",TRUE
+"1566932_x_at",0.930952156428186,0.694651214006414,0.397708028171552,-5.86293615787579,0.15129374216427,"TFB2M","transcription factor B2, mitochondrial",TRUE
+"1566930_at",0.972819824894874,0.86848346145779,-0.167516185877483,-5.92602491002956,-0.206951276109039,"TFB2M","transcription factor B2, mitochondrial",TRUE
+"207627_s_at",0.773234064853267,0.284304936498061,1.09727196531909,-5.36967753156312,1.4646045732019,"TFCP2","transcription factor CP2",TRUE
+"209338_at",0.783844746433788,0.306511970444327,1.04672402529499,-5.41968246144639,1.17086219094062,"TFCP2","transcription factor CP2",TRUE
+"227637_at",0.9114480626414,0.629690039116491,0.488938626103193,-5.8239117132139,0.513983516744119,"TFCP2","transcription factor CP2",TRUE
+"227642_at",0.668518995965071,0.134676263765131,1.55264398533625,-4.82913799124309,1.40412599510404,"TFCP2L1","transcription factor CP2-like 1",TRUE
+"219735_s_at",0.902681832009074,0.602009750121533,0.52908159935749,-5.80425326978095,0.39102146588459,"TFCP2L1","transcription factor CP2-like 1",TRUE
+"229341_at",0.915766032166572,0.644770880847734,-0.467409997771666,-5.83383035717084,-0.370688072504873,"TFCP2L1","transcription factor CP2-like 1",TRUE
+"212330_at",0.360736459722853,0.0102939556114761,2.80417168093608,-2.69889263247819,0.934594455188744,"TFDP1","transcription factor Dp-1",TRUE
+"204147_s_at",0.403395889022044,0.0149627226874569,2.63822352757273,-3.02122318521135,1.0938814828355,"TFDP1","transcription factor Dp-1",TRUE
+"242939_at",0.910276798053706,0.627116124362729,0.492636254556915,-5.82216422038849,0.259805146228349,"TFDP1","transcription factor Dp-1",TRUE
+"203588_s_at",0.941311073534434,0.737326206946816,0.339639845359588,-5.88365385726659,0.223970527769255,"TFDP2","transcription factor Dp-2",TRUE
+"226157_at",0.986342822130003,0.933557018433162,0.0843228345235277,-5.93622088939394,0.0493718557843383,"TFDP2","transcription factor Dp-2",TRUE
+"244043_at",0.988303954498837,0.944335962133488,-0.0706171697039018,-5.93725489365958,-0.0599279641989776,"TFDP2","transcription factor Dp-2",TRUE
+"203589_s_at",0.999503346640971,0.998565728001725,-0.00181798493550707,-5.93968187097187,-0.00126005413442876,"TFDP2","transcription factor Dp-2",TRUE
+"207385_at",0.550213045400235,0.0487409086571505,2.08559310519648,-4.01771514605373,0.756508772369143,"TFDP3","transcription factor Dp family member 3",TRUE
+"206649_s_at",0.528328646587879,0.0408978302251494,-2.171197118477,-3.8723851721165,-0.64736596609634,"TFE3","transcription factor binding to IGHM enhancer 3",TRUE
+"212457_at",0.552420073963858,0.0499619234015655,-2.07339825855008,-4.03811370103019,-0.671345760598388,"TFE3","transcription factor binding to IGHM enhancer 3",TRUE
+"1567704_at",0.947062793209778,0.759659390338172,-0.309731509911505,-5.89306547296396,-0.1298388445418,"TFE3","transcription factor binding to IGHM enhancer 3",TRUE
+"1565347_s_at",0.995623666221824,0.979216589435983,-0.026346797689058,-5.9393453897071,-0.0135891106160635,"TFE3","transcription factor binding to IGHM enhancer 3",TRUE
+"221866_at",0.366473876333673,0.0107988272642134,2.78311040147538,-2.74028748671225,1.48349501743384,"TFEB","transcription factor EB",TRUE
+"50221_at",0.588467901034655,0.0671235240311193,1.92529679676735,-4.27947058622742,1.36508113130767,"TFEB","transcription factor EB",TRUE
+"206715_at",0.190498595861526,0.00194418320056208,3.51348197697372,-1.242320368272,2.719737793983,"TFEC","transcription factor EC",TRUE
+"232383_at",0.861981304384929,0.48474190866049,0.710605877255278,-5.69668385125805,0.787865237213415,"TFEC","transcription factor EC",TRUE
+"236995_x_at",0.937113154905832,0.720101077517395,0.362923823702107,-5.87573342274538,0.40439887375081,"TFEC","transcription factor EC",TRUE
+"205009_at",0.677013732819214,0.144447661208654,-1.51286638105151,-4.88245121506021,-2.81193539623232,"TFF1","trefoil factor 1",TRUE
+"214476_at",0.330171916405281,0.0079539569238098,2.9167789727116,-2.47536522099989,2.40515308770125,"TFF2","trefoil factor 2",TRUE
+"204623_at",0.589837057564116,0.0680296785251212,-1.91845057671317,-4.29033333114784,-3.10852857094716,"TFF3","trefoil factor 3",TRUE
+"239385_at",0.697172073261335,0.167454320324828,1.42723495290082,-4.99343597611357,1.13951832171263,"TFG","TRK-fused gene",TRUE
+"221871_s_at",0.768852835478002,0.273067578834189,1.12394256650319,-5.34244813335976,0.36283869862946,"TFG","TRK-fused gene",TRUE
+"244614_at",0.779190122533958,0.300303507307463,1.06058479946845,-5.40618068149447,0.535181763833186,"TFG","TRK-fused gene",TRUE
+"217839_at",0.923376218980614,0.671063090038386,0.430398885771826,-5.84985889705308,0.128190522056371,"TFG","TRK-fused gene",TRUE
+"202751_at",0.756952614607938,0.252525405922303,1.17485354304452,-5.28887130154907,0.606633639493058,"TFIP11","tuftelin interacting protein 11",TRUE
+"202750_s_at",0.958283314963904,0.811320249651196,-0.241589322691745,-5.91129576128016,-0.0756601269824415,"TFIP11","tuftelin interacting protein 11",TRUE
+"214378_at",0.597654932724127,0.0747524462001979,1.87001731333602,-4.36640926625752,1.37659237093066,"TFPI","tissue factor pathway inhibitor",TRUE
+"210665_at",0.848376789225697,0.448406906147699,-0.771765578422869,-5.65366868366877,-1.06168779434385,"TFPI","tissue factor pathway inhibitor",TRUE
+"210664_s_at",0.895213601869362,0.573281344776297,0.571697895399869,-5.78173415106276,0.944128137762019,"TFPI","tissue factor pathway inhibitor",TRUE
+"209676_at",0.895657764833717,0.575199887205983,0.568819198907763,-5.78330857706011,0.968442723922183,"TFPI","tissue factor pathway inhibitor",TRUE
+"213258_at",0.909052380289506,0.621922125896331,0.500119160599239,-5.81858847406164,0.824340814646487,"TFPI","tissue factor pathway inhibitor",TRUE
+"209278_s_at",0.637485146909712,0.108265773723101,1.67362260641111,-4.66038273853767,3.50346279836601,"TFPI2","tissue factor pathway inhibitor 2",TRUE
+"209277_at",0.715644762361881,0.191400975040341,1.34761713120017,-5.09185320203243,2.45435546692397,"TFPI2","tissue factor pathway inhibitor 2",TRUE
+"218996_at",0.542397752248982,0.0455476464841838,-2.11883211596087,-3.96172565690141,-1.03684220004027,"TFPT","TCF3 fusion partner",TRUE
+"210215_at",0.854184492233394,0.464281718563927,0.744695882770065,-5.67312256806999,0.735526907250172,"TFR2","transferrin receptor 2",TRUE
+"215863_at",0.918589448829797,0.654151211232727,0.454131986882914,-5.83972976202274,0.193880544542423,"TFR2","transferrin receptor 2",TRUE
+"207883_s_at",0.998709719538178,0.994380607447998,0.00712281590907793,-5.93965876987177,0.0022022083456914,"TFR2","transferrin receptor 2",TRUE
+"237214_at",0.589837057564116,0.0680319878646773,1.91843323172111,-4.29036081804005,1.26926796598158,"TFRC","transferrin receptor",TRUE
+"240686_x_at",0.67565343307767,0.142172739313198,1.52192501198484,-4.87040684328153,1.21271285670864,"TFRC","transferrin receptor",TRUE
+"237215_s_at",0.92466349766724,0.674131884446505,0.42611952591305,-5.85162850219953,0.238781090801078,"TFRC","transferrin receptor",TRUE
+"207332_s_at",0.97127531853221,0.863746658210757,-0.173612152743004,-5.92501347763316,-0.0499817422271782,"TFRC","transferrin receptor",TRUE
+"208691_at",0.972579894639986,0.86746833364451,-0.168822036348668,-5.92581127951612,-0.0449436912120582,"TFRC","transferrin receptor",TRUE
+"203673_at",0.948951323154927,0.767464805182209,0.299347609724222,-5.8961322439297,0.103797930932338,"TG","thyroglobulin",TRUE
+"208249_s_at",0.737123149977386,0.222927957196181,1.25395394983665,-5.20153723345901,0.425480252274683,"TGDS","TDP-glucose 4,6-dehydratase",TRUE
+"237346_at",0.774011928861764,0.285560525175454,1.09433975995489,-5.37263572182079,0.663585209516656,"TGDS","TDP-glucose 4,6-dehydratase",TRUE
+"205015_s_at",0.181358093561736,0.00168558207498227,3.57270239294882,-1.11668608114627,3.86364378297175,"TGFA","transforming growth factor alpha",TRUE
+"211258_s_at",0.250841691547337,0.00355559782257313,3.2609112324903,-1.77257177729919,1.52611114886213,"TGFA","transforming growth factor alpha",TRUE
+"205016_at",0.452515768626633,0.0217673239866858,2.46815946940398,-3.34157561581611,3.07862241566327,"TGFA","transforming growth factor alpha",TRUE
+"203085_s_at",0.760237493549547,0.258318471925318,1.16019543654313,-5.30451062774358,1.63645618483899,"TGFB1","transforming growth factor beta 1",TRUE
+"203084_at",0.93565329131222,0.713396951312767,0.372040924628683,-5.87249085274775,0.267486975521799,"TGFB1","transforming growth factor beta 1",TRUE
+"209651_at",0.497725944448536,0.0304858137487166,2.31146214152822,-3.6265638358715,3.22067257490279,"TGFB1I1","transforming growth factor beta 1 induced transcript 1",TRUE
+"220407_s_at",0.643668420247444,0.114241061630978,1.64424499041358,-4.70225834679174,1.93065785686056,"TGFB2","transforming growth factor beta 2",TRUE
+"209908_s_at",0.666354937030012,0.133166705205765,1.55899972832884,-4.82051811146475,2.29894142807898,"TGFB2","transforming growth factor beta 2",TRUE
+"228121_at",0.689168483917391,0.158291318171643,1.46012296338142,-4.95143024085994,1.9116192411315,"TGFB2","transforming growth factor beta 2",TRUE
+"209909_s_at",0.701510769866251,0.173148382978419,1.40751968977672,-5.01824108859075,1.94533419796012,"TGFB2","transforming growth factor beta 2",TRUE
+"220406_at",0.775341201891078,0.291863603804628,-1.07975893430626,-5.38724098644336,-0.541560705152779,"TGFB2","transforming growth factor beta 2",TRUE
+"209747_at",0.522667179791589,0.0384195379891544,-2.20134956694397,-3.82032749455429,-1.39686309835286,"TGFB3","transforming growth factor beta 3",TRUE
+"1555540_at",0.624988420005843,0.096314436046597,1.73676039915021,-4.56849541638672,1.41989259182277,"TGFB3","transforming growth factor beta 3",TRUE
+"201506_at",0.149201481153625,0.00105607632750714,3.76568752020019,-0.70468738400019,5.90195062575989,"TGFBI","transforming growth factor beta induced",TRUE
+"236561_at",0.729083413548563,0.211051780189896,1.28795304472575,-5.16249807578765,1.33976845482838,"TGFBR1","transforming growth factor beta receptor 1",TRUE
+"206943_at",0.795497760925102,0.327685424262554,1.00089166251304,-5.46318636911547,0.436137878536973,"TGFBR1","transforming growth factor beta receptor 1",TRUE
+"224793_s_at",0.868397087637799,0.503575119750671,0.679956519684864,-5.71696888043169,0.316072045313577,"TGFBR1","transforming growth factor beta receptor 1",TRUE
+"207334_s_at",0.413584432973372,0.0166531453731728,2.59007691649653,-3.113003362037,2.70573958634094,"TGFBR2","transforming growth factor beta receptor 2",TRUE
+"208944_at",0.429284714913652,0.0189456505434914,2.53163264210519,-3.22328104584633,2.17421407128543,"TGFBR2","transforming growth factor beta receptor 2",TRUE
+"204731_at",0.813065886130395,0.362859044915586,-0.929081255487489,-5.52777882105699,-1.13246970033998,"TGFBR3","transforming growth factor beta receptor 3",TRUE
+"226625_at",0.897949253801113,0.586017247787982,-0.552677749852054,-5.79199390155859,-0.660444704405476,"TGFBR3","transforming growth factor beta receptor 3",TRUE
+"225653_at",0.647518308302168,0.118505090235495,-1.62406173650331,-4.73069865063616,-0.513555735726545,"TGFBRAP1","transforming growth factor beta receptor associated protein 1",TRUE
+"205210_at",0.812302873476553,0.360850521417499,-0.933051541378263,-5.52432263627079,-0.406926014644483,"TGFBRAP1","transforming growth factor beta receptor associated protein 1",TRUE
+"221235_s_at",0.839466826665106,0.425742116957332,-0.811444455199472,-5.62397052467052,-0.252828839772317,"TGFBRAP1","transforming growth factor beta receptor associated protein 1",TRUE
+"1566901_at",0.502098735582167,0.0323528824043159,2.28337473836295,-3.67652069838283,1.36186712147439,"TGIF1","TGFB induced factor homeobox 1",TRUE
+"203313_s_at",0.728671251879936,0.210244094240551,1.29031833321701,-5.15974904210634,0.691433768554996,"TGIF1","TGFB induced factor homeobox 1",TRUE
+"244858_at",0.816800680706682,0.368551853600605,0.917907384512133,-5.53743300344783,0.565038398144237,"TGIF1","TGFB induced factor homeobox 1",TRUE
+"218724_s_at",0.819203514175924,0.376038362233673,-0.903386123915247,-5.54981833838632,-0.404130279895702,"TGIF2","TGFB induced factor homeobox 2",TRUE
+"216262_s_at",0.87045636854107,0.509180376754689,-0.670960576306386,-5.72276051470575,-0.341222204363614,"TGIF2","TGFB induced factor homeobox 2",TRUE
+"217835_x_at",0.87889533384278,0.532368645015184,-0.634317818462588,-5.74558670527524,-0.202340865453625,"TGIF2-C20orf24///C20orf24","TGIF2-C20orf24 readthrough///chromosome 20 open reading frame 24",TRUE
+"223880_x_at",0.911393258378799,0.629565625650672,-0.489117196410122,-5.82382761681925,-0.159226671760743,"TGIF2-C20orf24///C20orf24","TGIF2-C20orf24 readthrough///chromosome 20 open reading frame 24",TRUE
+"224376_s_at",0.91876780831279,0.654456573740282,-0.453701144409966,-5.83991839411429,-0.159648158096923,"TGIF2-C20orf24///C20orf24","TGIF2-C20orf24 readthrough///chromosome 20 open reading frame 24",TRUE
+"233178_at",0.68523944045982,0.15382951791868,1.47669756615616,-4.92996623952782,0.591240303017767,"TGIF2LY","TGFB induced factor homeobox 2 like, Y-linked",TRUE
+"206008_at",0.61299046462692,0.0845557540291736,1.80579617403542,-4.4651513635937,1.23155126287467,"TGM1","transglutaminase 1",TRUE
+"201042_at",0.30514766112199,0.00605247964364136,3.03469356539383,-2.23763206546149,4.28913835269907,"TGM2","transglutaminase 2",TRUE
+"211573_x_at",0.398743678334163,0.0140107611534492,2.66764050689551,-2.96474701276038,3.93172781378615,"TGM2","transglutaminase 2",TRUE
+"211003_x_at",0.493058629078403,0.0296691652593658,2.32424654244273,-3.60370795743095,4.14129338574533,"TGM2","transglutaminase 2",TRUE
+"216183_at",0.841175185633249,0.431039922863755,0.802055116874087,-5.63112453254827,0.665795216354819,"TGM2","transglutaminase 2",TRUE
+"206004_at",0.951339758531576,0.777275926633221,-0.286342766487979,-5.89982682926372,-0.275048390247992,"TGM3","transglutaminase 3",TRUE
+"217567_at",0.819018525257656,0.37440235463397,0.906542964016705,-5.54714134513187,0.73785000212845,"TGM4","transglutaminase 4",TRUE
+"206260_at",0.868397087637799,0.50327811014415,0.680434762838767,-5.71665891956503,0.440058637167488,"TGM4","transglutaminase 4",TRUE
+"217566_s_at",0.968035667633768,0.849327430857899,-0.192211340589665,-5.92170484014976,-0.105582788235782,"TGM4","transglutaminase 4",TRUE
+"207911_s_at",0.657015752622694,0.125857965970327,-1.59064353581185,-4.77719069791122,-0.903032601589493,"TGM5","transglutaminase 5",TRUE
+"233983_at",0.62110896023334,0.0911088006546608,1.76637484618705,-4.52452551953903,0.84018048467021,"TGM6","transglutaminase 6",TRUE
+"237288_at",0.646392036827936,0.117410412792362,1.62918436118288,-4.72350592652969,0.988935758534717,"TGM7","transglutaminase 7",TRUE
+"203833_s_at",0.463598473166611,0.023705224516579,2.42886152092236,-3.41401405703754,0.739311707705792,"TGOLN2","trans-golgi network protein 2",TRUE
+"203834_s_at",0.470726957161354,0.0253376225365437,2.39800482317097,-3.47044869057145,0.700334814270096,"TGOLN2","trans-golgi network protein 2",TRUE
+"1554608_at",0.61190373281876,0.0836464288813428,1.8114731444631,-4.45652269567045,1.323297703945,"TGOLN2","trans-golgi network protein 2",TRUE
+"212040_at",0.647382402854918,0.118180590084955,1.62557610843513,-4.72857412471682,0.562856356509409,"TGOLN2","trans-golgi network protein 2",TRUE
+"212043_at",0.892178923218045,0.564355824958603,0.585155200296327,-5.7742719608135,0.200585118547139,"TGOLN2","trans-golgi network protein 2",TRUE
+"236371_s_at",0.627092759817312,0.0984881745215721,1.72479821005544,-4.58609992021706,1.13857063943628,"TGS1","trimethylguanosine synthase 1",TRUE
+"238346_s_at",0.863569008901048,0.488840189853697,0.703878966613765,-5.70120905566502,0.275033452394966,"TGS1","trimethylguanosine synthase 1",TRUE
+"219231_at",0.91876780831279,0.654508354823857,0.45362809402449,-5.83995035973971,0.170956637590129,"TGS1","trimethylguanosine synthase 1",TRUE
+"208291_s_at",0.767965891104819,0.271097763128706,-1.12869974303512,-5.33753044931649,-1.26872478674831,"TH","tyrosine hydroxylase",TRUE
+"237074_at",0.784124901877429,0.307253624102826,1.04508159609292,-5.42127177545372,0.761372556174511,"TH2LCRR","T helper type 2 locus control region associated RNA",TRUE
+"1563389_at",0.976371465776674,0.886431011714982,-0.144475621156698,-5.92952202304161,-0.088544459827486,"TH2LCRR","T helper type 2 locus control region associated RNA",TRUE
+"1554492_at",0.569024683825503,0.0588018191790414,1.992294667564,-4.17177229296523,2.03531283518329,"THADA","THADA, armadillo repeat containing",TRUE
+"1566888_at",0.61760967235709,0.087961188999527,1.78499390447446,-4.49660161526093,1.06386296959901,"THADA","THADA, armadillo repeat containing",TRUE
+"1554493_s_at",0.722288531465626,0.198709620713893,1.32489135437015,-5.11907954604669,0.478985751547913,"THADA","THADA, armadillo repeat containing",TRUE
+"220212_s_at",0.784552021081681,0.30827262567304,1.04282953494007,-5.42344735679368,0.352199343717427,"THADA","THADA, armadillo repeat containing",TRUE
+"1566889_at",0.860085676417428,0.47938861778484,0.719442590494038,-5.69067711192223,0.71073318404601,"THADA","THADA, armadillo repeat containing",TRUE
+"54632_at",0.893928800286346,0.570079970534681,0.576512332743658,-5.77908381729899,0.216560767874453,"THADA","THADA, armadillo repeat containing",TRUE
+"1558306_at",0.918041148686074,0.651650108391668,-0.457664142892303,-5.83817669144543,-0.279722239083108,"THADA","THADA, armadillo repeat containing",TRUE
+"219292_at",0.672434875127089,0.138382035743099,-1.5372872733135,-4.8498504193331,-0.539469179437541,"THAP1","THAP domain containing 1",TRUE
+"219596_at",0.94118897722809,0.736713136461281,-0.340465206367205,-5.88338196893864,-0.16935254302755,"THAP10","THAP domain containing 10",TRUE
+"212910_at",0.595019326272843,0.0719302259374015,-1.88986543397309,-4.33539776178469,-0.543438613578237,"THAP11","THAP domain containing 11",TRUE
+"209323_at",0.991689960875868,0.961554745136388,0.0487507172504235,-5.9385259770123,0.0218667781914164,"THAP12","THAP domain containing 12",TRUE
+"223588_at",0.685859885819241,0.154169510685294,-1.47542093812113,-4.93162642861677,-0.680445367619918,"THAP2","THAP domain containing 2",TRUE
+"244499_at",0.774230543658252,0.286637133348898,-1.09183294076508,-5.37515916880048,-0.749904279910856,"THAP2","THAP domain containing 2",TRUE
+"230380_at",0.937623890519979,0.723749642226452,0.357975241762448,-5.87746016764973,0.188071500342818,"THAP2","THAP domain containing 2",TRUE
+"217658_at",0.729789891627758,0.212184999525691,1.28464620406661,-5.16633422573541,0.649021580059525,"THAP3","THAP domain containing 3",TRUE
+"213192_at",0.90344422113846,0.604058873293329,-0.526080349077577,-5.80577526843064,-0.53535754425734,"THAP3","THAP domain containing 3",TRUE
+"220417_s_at",0.580630437263151,0.0633091930039171,-1.95503777716511,-4.23197240871643,-0.551738376066647,"THAP4","THAP domain containing 4",TRUE
+"224057_s_at",0.594005743610726,0.0708585878841809,-1.8975808449618,-4.32328092814349,-0.567260316053606,"THAP4","THAP domain containing 4",TRUE
+"244190_at",0.853460708803218,0.462075113074486,0.748425020661201,-5.67048163415368,0.598901842727631,"THAP5","THAP domain containing 5",TRUE
+"227636_at",0.980009054680439,0.905462713102496,-0.120130158061916,-5.93265699207637,-0.0389553901470716,"THAP5","THAP domain containing 5",TRUE
+"235653_s_at",0.786851686785014,0.312601481582293,1.03332065912467,-5.43258671543201,0.346952271066537,"THAP6","THAP domain containing 6",TRUE
+"230169_at",0.898726367439655,0.588433589421212,0.549092475245331,-5.79389011268226,0.239307303217723,"THAP6","THAP domain containing 6",TRUE
+"235218_x_at",0.92070400963176,0.662515351584673,-0.442362002990384,-5.84481978490706,-0.148609596571946,"THAP6","THAP domain containing 6",TRUE
+"227813_at",0.955316686567461,0.795459487383086,-0.262370939474215,-5.90621028856581,-0.0899062203829253,"THAP6","THAP domain containing 6",TRUE
+"218492_s_at",0.552420073963858,0.050033744202762,-2.07268929654132,-4.03929721070059,-0.648778931709881,"THAP7","THAP domain containing 7",TRUE
+"239015_at",0.42796179417767,0.0185530112108487,-2.54115565378422,-3.20539913679219,-1.58175458879765,"THAP7-AS1","THAP7 antisense RNA 1",TRUE
+"236403_at",0.906970705662734,0.615350129735812,0.509629045950033,-5.81396821699293,0.299602181300789,"THAP7-AS1","THAP7 antisense RNA 1",TRUE
+"228500_at",0.526634268561088,0.039780680818095,-2.1845779865768,-3.84933796031825,-0.740228601038372,"THAP8","THAP domain containing 8",TRUE
+"230185_at",0.91994485246627,0.659263962731559,0.446929713121211,-5.84286000810588,0.131043724966464,"THAP9","THAP domain containing 9",TRUE
+"220360_at",0.929234395612144,0.688673479913555,0.405949555312953,-5.8597350872057,0.166391958519356,"THAP9","THAP domain containing 9",TRUE
+"215009_s_at",0.927347650285659,0.681954585734531,0.415247225663607,-5.8560462481381,0.231602765640316,"THAP9-AS1","THAP9 antisense RNA 1",TRUE
+"203887_s_at",0.910165867297668,0.626797733358203,0.493094131252371,-5.82194693371014,0.57772789126316,"THBD","thrombomodulin",TRUE
+"237252_at",0.975159323713639,0.879013985370267,-0.153986958388772,-5.92814084297087,-0.156810868884867,"THBD","thrombomodulin",TRUE
+"203888_at",0.994683443051162,0.975262206072247,0.0313612868745511,-5.93920445074934,0.0384634080304629,"THBD","thrombomodulin",TRUE
+"201108_s_at",0.566644160327613,0.0570822664209432,2.00717813967039,-4.14750962616344,1.53206014695395,"THBS1","thrombospondin 1",TRUE
+"201109_s_at",0.578441573439199,0.0617345158361912,1.96777897656954,-4.21147173767352,1.68173671247986,"THBS1","thrombospondin 1",TRUE
+"201110_s_at",0.593904766176258,0.0706877539736863,1.89882021967032,-4.32133130874995,1.71595792164231,"THBS1","thrombospondin 1",TRUE
+"201107_s_at",0.606900628956089,0.0806091286056437,1.83083063940743,-4.42695380080939,2.1120595316281,"THBS1","thrombospondin 1",TRUE
+"235086_at",0.634613664184235,0.105589035264453,1.68722926143475,-4.64079678647239,1.47109256237841,"THBS1","thrombospondin 1",TRUE
+"239336_at",0.710842845257879,0.184536728500557,1.36959109758221,-5.06515929601007,1.46894334162026,"THBS1","thrombospondin 1",TRUE
+"215775_at",0.71454754703986,0.189499558572679,1.35364094673887,-5.08457137829557,0.458799442374063,"THBS1","thrombospondin 1",TRUE
+"203083_at",0.670049132021098,0.135713289218137,1.54831178143701,-4.83499755034422,1.06605517044528,"THBS2","thrombospondin 2",TRUE
+"209561_at",0.591331966259927,0.0687124809286177,-1.91334457181792,-4.29841745880332,-0.895030484121932,"THBS3","thrombospondin 3",TRUE
+"204776_at",0.773754791548713,0.285289831451638,1.09497112814599,-5.37199935361069,0.637607582730239,"THBS4","thrombospondin 4",TRUE
+"236842_at",0.762252900774908,0.261723121334217,1.15169409389533,-5.31350212854124,0.442049853527067,"THCAT158","thyroid cancer-associated transcript 158",TRUE
+"243115_at",0.94895689004559,0.768791349311963,0.2975862145575,-5.8966421697643,0.242594530931648,"THCAT158","thyroid cancer-associated transcript 158",TRUE
+"220808_at",0.937203701144735,0.72117916411642,-0.361460649166519,-5.87624641655076,-0.2188389859608,"THEG","theg spermatid protein",TRUE
+"242084_at",0.983536402415622,0.919676242770895,-0.101997342871263,-5.93461760997793,-0.0645239272056441,"THEG5","testis highly expressed protein 5",TRUE
+"229253_at",0.730048787941067,0.21237541065193,1.28409190569881,-5.16697642639217,0.526312225393504,"THEM4","thioesterase superfamily member 4",TRUE
+"243492_at",0.841088238127348,0.430873414027334,0.80234912702968,-5.63090170380525,0.300917198548093,"THEM4","thioesterase superfamily member 4",TRUE
+"1553118_at",0.888972420461865,0.55638729032977,0.597262408335918,-5.76741492208106,0.234031432995986,"THEM4","thioesterase superfamily member 4",TRUE
+"1562490_at",0.892746695408886,0.565421834748061,0.583542242518365,-5.77517522314635,0.46735988003034,"THEM5","thioesterase superfamily member 5",TRUE
+"218500_at",0.764430688544079,0.264578217861039,-1.14462773195401,-5.32093166605669,-0.684122178446653,"THEM6","thioesterase superfamily member 6",TRUE
+"1558971_at",0.740610299769501,0.230567720224533,1.23280958911634,-5.22536403990731,1.04216364939887,"THEMIS","thymocyte selection associated",TRUE
+"1558972_s_at",0.910165000118714,0.626136920886423,0.494044784074913,-5.8214951690705,0.448843315589594,"THEMIS","thymocyte selection associated",TRUE
+"210785_s_at",0.291020678465228,0.00508853714883873,3.10891765710276,-2.0862504027034,1.24440109290949,"THEMIS2","thymocyte selection associated family member 2",TRUE
+"207571_x_at",0.592111379991983,0.06919241581409,1.9097822079637,-4.30404874446883,1.54453018209847,"THEMIS2","thymocyte selection associated family member 2",TRUE
+"219122_s_at",0.876278327062923,0.524947014103171,0.645948528059131,-5.73847477875975,0.237203861443447,"THG1L","tRNA-histidine guanylyltransferase 1 like",TRUE
+"222931_s_at",0.763391321581193,0.263131512406867,-1.14820125863696,-5.3171795050239,-0.411805706970979,"THNSL1","threonine synthase like 1",TRUE
+"219800_s_at",0.974884920935236,0.876894379116161,-0.1567077027659,-5.92772959682183,-0.109668323790042,"THNSL1","threonine synthase like 1",TRUE
+"219044_at",0.92265243752289,0.669417040726388,0.432697627340915,-5.84890114806062,0.256338958781949,"THNSL2","threonine synthase like 2",TRUE
+"239949_at",0.942502815705589,0.74205964974377,0.333275375632016,-5.88572850157284,0.142472316914367,"THNSL2","threonine synthase like 2",TRUE
+"204064_at",0.873298450403981,0.518021314010094,0.656883467981924,-5.73167513937603,0.254791978158309,"THOC1","THO complex 1",TRUE
+"226626_at",0.662575055303091,0.130303078587127,-1.5712221655793,-4.80386377959958,-0.546180615751434,"THOC2","THO complex 2",TRUE
+"212994_at",0.725934062811456,0.205000858341269,-1.30584656757388,-5.14159521853163,-0.467674342437119,"THOC2","THO complex 2",TRUE
+"226628_at",0.731054546207485,0.213708268536908,-1.28022257587482,-5.17145279023803,-0.59985654787293,"THOC2","THO complex 2",TRUE
+"222122_s_at",0.826140850652187,0.394082000756151,-0.869151949372385,-5.57829315247199,-0.286645963944618,"THOC2","THO complex 2",TRUE
+"209418_s_at",0.819018525257656,0.37409341582324,-0.907140114719603,-5.54663399271564,-0.32241554663114,"THOC5","THO complex 5",TRUE
+"209419_at",0.855405088766616,0.468072413486154,-0.73831417208786,-5.67761300965226,-0.421539577605099,"THOC5","THO complex 5",TRUE
+"218848_at",0.91704891241952,0.648933659870202,0.461507129020443,-5.83647355762235,0.189415256686114,"THOC6","THO complex 6",TRUE
+"218334_at",0.859064198633089,0.475672197510518,-0.725611187088305,-5.68644217527519,-0.405617572681177,"THOC7","THO complex 7",TRUE
+"203235_at",0.990810941805126,0.954806377194092,-0.0573170890309628,-5.93808348390906,-0.0228503737864969,"THOP1","thimet oligopeptidase 1",TRUE
+"211831_s_at",0.713633547141264,0.188686217927936,-1.35623220376745,-5.08143061242886,-0.766683039366948,"THPO","thrombopoietin",TRUE
+"211155_s_at",0.714791050845163,0.190233741828554,-1.35130939178811,-5.08739307631086,-1.10550064378872,"THPO","thrombopoietin",TRUE
+"211154_at",0.942303845415102,0.740635919069067,-0.335188200657058,-5.885109052859,-0.24097982881037,"THPO","thrombopoietin",TRUE
+"214883_at",0.590570903980459,0.0682795150232074,1.91657709633834,-4.29330127072893,0.911610955298294,"THRA","thyroid hormone receptor, alpha",TRUE
+"1316_at",0.745996390953656,0.237527139764186,-1.21400665579637,-5.2462585970359,-0.394245241443901,"THRA","thyroid hormone receptor, alpha",TRUE
+"204100_at",0.856257656023992,0.469784296679262,-0.735442220199922,-5.67962187491228,-0.49927111287294,"THRA","thyroid hormone receptor, alpha",TRUE
+"35846_at",0.935351255251442,0.712646131504514,-0.373063970908221,-5.87212204407682,-0.23797431995332,"THRA","thyroid hormone receptor, alpha",TRUE
+"1560861_at",0.915438698231633,0.643645074301243,-0.46900929558713,-5.8331085564664,-0.685828357498307,"THRA1/BTR","uncharacterized LOC105371807",TRUE
+"242163_at",0.812302873476553,0.357146878365258,0.940411654669445,-5.51787975095181,0.659855716717621,"THRAP3","thyroid hormone receptor associated protein 3",TRUE
+"222439_s_at",0.865573853395686,0.495518273640329,0.692986723899229,-5.70844924190576,0.55028028854754,"THRAP3","thyroid hormone receptor associated protein 3",TRUE
+"222440_s_at",0.896428361916712,0.580789363783883,-0.560459900305395,-5.78783679248923,-0.130171756677932,"THRAP3","thyroid hormone receptor associated protein 3",TRUE
+"217847_s_at",0.95194340202313,0.780296402125248,-0.282349300143177,-5.90092868011508,-0.188807708239035,"THRAP3","thyroid hormone receptor associated protein 3",TRUE
+"207044_at",0.710842845257879,0.18457163154201,1.36947774540109,-5.06529791955198,0.471085977408616,"THRB","thyroid hormone receptor beta",TRUE
+"229657_at",0.923802644326619,0.672690529100607,-0.428128448921902,-5.8507999338204,-0.320004378099402,"THRB","thyroid hormone receptor beta",TRUE
+"228716_at",0.984132887597385,0.922115562513183,-0.0988890885964148,-5.9349215873166,-0.0746535166160092,"THRB","thyroid hormone receptor beta",TRUE
+"231810_at",0.986145735582101,0.932211782635516,0.0860344385835363,-5.93607891913412,0.0419700781214267,"THRIL///BRI3BP","TNF and HNRNPL related immunoregulatory long non-coding RNA///BRI3 binding protein",TRUE
+"229476_s_at",0.565956563686213,0.0568028597543959,-2.00963404408715,-4.14349446512558,-3.45106728970766,"THRSP","thyroid hormone responsive",TRUE
+"1553583_a_at",0.740844137310891,0.231108140941464,-1.23133419263087,-5.22701358411373,-0.886097087548064,"THRSP","thyroid hormone responsive",TRUE
+"229477_at",0.809652358091397,0.35290769610453,-0.948899370798704,-5.51039212450235,-0.926417693630638,"THRSP","thyroid hormone responsive",TRUE
+"1555816_at",0.73293129460207,0.21711120708505,1.27042740548066,-5.18273315003932,1.19551111283549,"THSD4","thrombospondin type 1 domain containing 4",TRUE
+"219153_s_at",0.762729892034689,0.262298402772045,1.15026571340208,-5.31500716330085,0.86061264127524,"THSD4","thrombospondin type 1 domain containing 4",TRUE
+"226506_at",0.942303845415102,0.740594249515334,-0.335244204135356,-5.88509086386622,-0.185953514128592,"THSD4","thrombospondin type 1 domain containing 4",TRUE
+"234323_at",0.957390359236635,0.807112485614487,-0.247091587513768,-5.90998987963396,-0.18328601474256,"THSD4","thrombospondin type 1 domain containing 4",TRUE
+"1555817_s_at",0.99187501204911,0.962649394410133,0.0473615401234709,-5.93859100095632,0.04164242204331,"THSD4","thrombospondin type 1 domain containing 4",TRUE
+"222835_at",0.996862411648832,0.983891160403191,0.0204199328794551,-5.9394803902943,0.0146380507986148,"THSD4","thrombospondin type 1 domain containing 4",TRUE
+"1562524_at",0.768852835478002,0.27195517863291,1.12662595559939,-5.33967646373421,0.362931654280047,"THSD4-AS1","THSD4 antisense RNA 1",TRUE
+"229159_at",0.723762015297204,0.200720684736196,1.31875300152592,-5.12636666209547,1.92111030656426,"THSD7A","thrombospondin type 1 domain containing 7A",TRUE
+"213894_at",0.854400503339099,0.46566041536,0.742371252647263,-5.67476251893891,0.702144074345666,"THSD7A","thrombospondin type 1 domain containing 7A",TRUE
+"214920_at",0.905953010541442,0.612461004648837,0.51382476279892,-5.81190279731116,0.549378519254941,"THSD7A","thrombospondin type 1 domain containing 7A",TRUE
+"230008_at",0.931528703027792,0.697275564663322,-0.394098694688997,-5.86431769093694,-0.320815169913441,"THSD7A","thrombospondin type 1 domain containing 7A",TRUE
+"232327_at",0.908008907845691,0.618323259163487,0.505320987718887,-5.81607175245876,0.444284959426528,"THSD7B","thrombospondin type 1 domain containing 7B",TRUE
+"218540_at",0.51531387545335,0.0356391398358634,-2.23735654624918,-3.75758886730323,-0.89511794667053,"THTPA","thiamine triphosphatase",TRUE
+"213025_at",0.455629352117403,0.0222002120537862,-2.45910714742724,-3.35831718168857,-0.747221123137811,"THUMPD1","THUMP domain containing 1",TRUE
+"206555_s_at",0.739189560382301,0.226105180015084,-1.24509435422383,-5.21156319939598,-0.418713558780832,"THUMPD1","THUMP domain containing 1",TRUE
+"219248_at",0.584247456664678,0.0648614304740219,1.94274908920953,-4.25165878920403,0.703939302563972,"THUMPD2","THUMP domain containing 2",TRUE
+"225741_at",0.623667408398064,0.0949279593640564,-1.74451134123984,-4.55704032292443,-0.605476069087674,"THUMPD3","THUMP domain containing 3",TRUE
+"242377_x_at",0.916790160854655,0.648351318877112,0.462331889719112,-5.83610622184589,0.151759732623836,"THUMPD3","THUMP domain containing 3",TRUE
+"223804_s_at",0.923708852928185,0.672419498041055,-0.428506404737366,-5.85064362024712,-0.140589042639455,"THUMPD3","THUMP domain containing 3",TRUE
+"225730_s_at",0.936992192746977,0.71803028760458,-0.365736560171517,-5.8747415209106,-0.105460967986753,"THUMPD3","THUMP domain containing 3",TRUE
+"232052_at",0.765889357241662,0.266110656049746,1.14085810044663,-5.32487857306325,0.427178988262432,"THUMPD3-AS1","THUMPD3 antisense RNA 1",TRUE
+"1557357_at",0.812766018684251,0.361496918927547,0.931772183395216,-5.52543781336419,0.438493278888714,"THUMPD3-AS1","THUMPD3 antisense RNA 1",TRUE
+"1555858_at",0.861285105384486,0.481547771129371,0.715871592848082,-5.69311299733535,0.268370326854605,"THUMPD3-AS1","THUMPD3 antisense RNA 1",TRUE
+"1555860_x_at",0.93194437316997,0.699192650890392,0.39146544578047,-5.86531778275502,0.167599684163344,"THUMPD3-AS1","THUMPD3 antisense RNA 1",TRUE
+"208850_s_at",0.304824368772306,0.00598127053169195,3.03977251376884,-2.22731430487068,1.08731352142754,"THY1","Thy-1 cell surface antigen",TRUE
+"213869_x_at",0.51470556386048,0.034971958014367,2.24637651450115,-3.74177633992653,1.55247345380439,"THY1","Thy-1 cell surface antigen",TRUE
+"208851_s_at",0.7468442753788,0.238829260097481,1.21053499600054,-5.25008604125906,0.701463196672258,"THY1","Thy-1 cell surface antigen",TRUE
+"223711_s_at",0.946941640414848,0.759228152554035,0.310306208959468,-5.89289271580021,0.119232032232572,"THYN1","thymocyte nuclear protein 1",TRUE
+"218491_s_at",0.969859663161336,0.855671660457397,0.184019842800846,-5.92320336109068,0.0767974614182645,"THYN1","thymocyte nuclear protein 1",TRUE
+"201447_at",0.865854896594418,0.49614349320318,-0.691971275774231,-5.70911872955976,-0.173854776458944,"TIA1","TIA1 cytotoxic granule-associated RNA binding protein",TRUE
+"201448_at",0.865885012497452,0.496389707123527,-0.691571588611827,-5.70938198729705,-0.207608314106333,"TIA1","TIA1 cytotoxic granule-associated RNA binding protein",TRUE
+"1554890_a_at",0.899331416659389,0.589842432877449,-0.547005444274688,-5.79498839992774,-0.19923924604562,"TIA1","TIA1 cytotoxic granule-associated RNA binding protein",TRUE
+"201446_s_at",0.92247975200053,0.668774621121116,-0.433595422064485,-5.84852572980073,-0.112933130138206,"TIA1","TIA1 cytotoxic granule-associated RNA binding protein",TRUE
+"201449_at",0.932249295738588,0.701173500231886,-0.388747569999615,-5.86634308679085,-0.146200807678294,"TIA1","TIA1 cytotoxic granule-associated RNA binding protein",TRUE
+"1554889_at",0.975265330414469,0.88054759026851,0.152019153228735,-5.92843380250965,0.0684971302696038,"TIA1","TIA1 cytotoxic granule-associated RNA binding protein",TRUE
+"201450_s_at",0.994701128358967,0.975574850927114,0.030964798743146,-5.93921648627243,0.00901530612265411,"TIA1","TIA1 cytotoxic granule-associated RNA binding protein",TRUE
+"1560553_at",0.944646698916914,0.751018855678854,0.321267133928111,-5.88953709707479,0.180111621481638,"TIAF1","TGFB1-induced anti-apoptotic factor 1",TRUE
+"202406_s_at",0.945719871629175,0.754898076954954,0.316082737091364,-5.89113864537095,0.105505514254219,"TIAL1","TIA1 cytotoxic granule-associated RNA binding protein-like 1",TRUE
+"202405_at",0.967098812766994,0.846498642768223,-0.195868103613809,-5.92101489410509,-0.0879107619542747,"TIAL1","TIA1 cytotoxic granule-associated RNA binding protein-like 1",TRUE
+"230350_at",0.969946179106301,0.857607994874895,-0.181522290869712,-5.92364731555631,-0.100428457794642,"TIAL1","TIA1 cytotoxic granule-associated RNA binding protein-like 1",TRUE
+"217500_at",0.985498770484702,0.929887163244085,-0.088992780311639,-5.93582681564728,-0.059721842452479,"TIAL1","TIA1 cytotoxic granule-associated RNA binding protein-like 1",TRUE
+"213135_at",0.879207782726786,0.533040321569776,-0.633269566179267,-5.74622158478417,-0.422991996595606,"TIAM1","T-cell lymphoma invasion and metastasis 1",TRUE
+"206409_at",0.954569345112903,0.791707536136174,-0.26730391353402,-5.90494194383981,-0.199129743957088,"TIAM1","T-cell lymphoma invasion and metastasis 1",TRUE
+"222942_s_at",0.597654932724127,0.0740704392240676,1.8747529633517,-4.35903103565742,1.5750808230857,"TIAM2","T-cell lymphoma invasion and metastasis 2",TRUE
+"227866_at",0.623503825356688,0.0944415518003735,1.74725351313408,-4.5529786340283,0.778715555564943,"TIAM2","T-cell lymphoma invasion and metastasis 2",TRUE
+"219950_s_at",0.985709215004606,0.931058174412321,-0.0875024358233575,-5.93595488401069,-0.0494879026183224,"TIAM2","T-cell lymphoma invasion and metastasis 2",TRUE
+"213191_at",0.831732794659972,0.406503223391016,0.846171816792323,-5.59683354384753,0.3368294737813,"TICAM1","toll like receptor adaptor molecule 1",TRUE
+"230021_at",0.886023097762234,0.548575744353501,-0.6092191368614,-5.76051000560305,-0.241589655257235,"TICRR","TOPBP1 interacting checkpoint and replication regulator",TRUE
+"232475_at",0.986421906591669,0.936706865589652,-0.0803161424411613,-5.9365420793597,-0.058287569964059,"TICRR","TOPBP1 interacting checkpoint and replication regulator",TRUE
+"1560657_at",0.936599157163462,0.717040100970246,0.367082583987787,-5.87426417583613,0.288211587980676,"TIE1","tyrosine kinase with immunoglobulin like and EGF like domains 1",TRUE
+"204468_s_at",0.942502815705589,0.74182231428919,-0.333594154702553,-5.88562551179,-0.0962584412349539,"TIE1","tyrosine kinase with immunoglobulin like and EGF like domains 1",TRUE
+"235971_at",0.841420204214686,0.432323561457945,0.799790912724814,-5.63283798946303,0.270913480008692,"TIFA","TRAF interacting protein with forkhead associated domain",TRUE
+"238858_at",0.947969282616012,0.763203680344449,-0.305012140327495,-5.89447213405989,-0.12130890006376,"TIFA","TRAF interacting protein with forkhead associated domain",TRUE
+"226117_at",0.959203345279235,0.815159360458096,0.236575772895245,-5.91246019094295,0.0926404353106349,"TIFA","TRAF interacting protein with forkhead associated domain",TRUE
+"236673_at",0.8943345793428,0.570786587423089,0.575448495673483,-5.77967130941057,0.367485029746056,"TIFAB","TIFA inhibitor",TRUE
+"239529_at",0.956960361976289,0.804995013677279,0.249863431721592,-5.909320950051,0.16769349442051,"TIFAB///DCANP1","TIFA inhibitor///dendritic cell associated nuclear protein",TRUE
+"219099_at",0.902268042923638,0.601082966537734,-0.530440629289422,-5.80356130438613,-0.247876411972763,"TIGAR","TP53 induced glycolysis regulatory phosphatase",TRUE
+"1553099_at",0.358427723880268,0.00997481765398902,-2.8179972542541,-2.67164638201281,-1.1302656409442,"TIGD1","tigger transposable element derived 1",TRUE
+"229983_at",0.643515428391208,0.114062830773041,1.64510231875664,-4.70104431445587,0.681738148005127,"TIGD2","tigger transposable element derived 2",TRUE
+"229789_at",0.67450217874052,0.14092068381807,-1.52696148198648,-4.86368556824573,-1.16939247983508,"TIGD3","tigger transposable element derived 3",TRUE
+"1552523_a_at",0.828535730541669,0.398674837607726,0.860601347976627,-5.5852458139693,0.411483400398248,"TIGD4","tigger transposable element derived 4",TRUE
+"1552522_at",0.860714927752408,0.48059928723097,-0.717439127960195,-5.69204515428292,-0.248114040699549,"TIGD4","tigger transposable element derived 4",TRUE
+"232998_at",0.888312537451395,0.554325643261561,-0.600409474187925,-5.76561033062322,-0.409758820284276,"TIGD4","tigger transposable element derived 4",TRUE
+"229758_at",0.969882914559333,0.856574066038215,-0.182855740429295,-5.92341103950727,-0.0823496961600387,"TIGD5","tigger transposable element derived 5",TRUE
+"220986_s_at",0.83633038614858,0.417735347041097,-0.82577441186415,-5.61290163382517,-0.27645779747683,"TIGD6","tigger transposable element derived 6",TRUE
+"224365_s_at",0.899998627338565,0.59442784858341,-0.54022962109845,-5.79852611618262,-0.31310546542042,"TIGD7","tigger transposable element derived 7",TRUE
+"238793_at",0.994098505325585,0.972830950756279,-0.0344447229390309,-5.9391056266078,-0.0257532506473028,"TIGD7","tigger transposable element derived 7",TRUE
+"240070_at",0.897593464839036,0.584638289343352,-0.554727079489573,-5.79090465247825,-0.457347932307193,"TIGIT","T-cell immunoreceptor with Ig and ITIM domains",TRUE
+"1552280_at",0.581128536542197,0.0636467778986146,1.95234275689998,-4.23629707670995,1.01625131603508,"TIMD4","T-cell immunoglobulin and mucin domain containing 4",TRUE
+"203046_s_at",0.662512980251591,0.130188193138054,-1.57171714187361,-4.8031871717263,-0.611084122981916,"TIMELESS","timeless circadian clock",TRUE
+"215455_at",0.983167907106595,0.918047794454346,0.104072931700557,-5.93440939127721,0.0738235325337655,"TIMELESS","timeless circadian clock",TRUE
+"218408_at",0.821187434813103,0.382555824059572,-0.890899066428681,-5.56032269034076,-0.329565431947348,"TIMM10","translocase of inner mitochondrial membrane 10 homolog (yeast)",TRUE
+"1555764_s_at",0.868397087637799,0.50410379729276,-0.679105639817912,-5.71751984082729,-0.259810175016993,"TIMM10","translocase of inner mitochondrial membrane 10 homolog (yeast)",TRUE
+"222481_at",0.741524051662535,0.232066173717378,-1.22872510306856,-5.2299264643161,-0.588000123053938,"TIMM10B","translocase of inner mitochondrial membrane 10 homolog B (yeast)",TRUE
+"217981_s_at",0.909052380289506,0.622392030613735,-0.499440991176577,-5.81891470966736,-0.206986944121025,"TIMM10B","translocase of inner mitochondrial membrane 10 homolog B (yeast)",TRUE
+"218188_s_at",0.735677568529031,0.22071808590651,-1.26017320881633,-5.19446278173089,-0.554804397058426,"TIMM13","translocase of inner mitochondrial membrane 13",TRUE
+"231749_at",0.812302873476553,0.359947202983804,-0.934841977482913,-5.52275960713317,-0.427907489302197,"TIMM13","translocase of inner mitochondrial membrane 13",TRUE
+"215171_s_at",0.238811487311851,0.00315904717972559,-3.31069062862309,-1.66887508633613,-1.12006746668885,"TIMM17A","translocase of inner mitochondrial membrane 17 homolog A (yeast)",TRUE
+"201821_s_at",0.477266692481162,0.0264901323274809,-2.3773075853891,-3.50807865083901,-0.857382529896556,"TIMM17A","translocase of inner mitochondrial membrane 17 homolog A (yeast)",TRUE
+"201822_at",0.527729326949923,0.040287923377942,-2.17846075370099,-3.85988515326055,-0.899626770023459,"TIMM17A","translocase of inner mitochondrial membrane 17 homolog A (yeast)",TRUE
+"215168_at",0.994304286761558,0.973959296280569,0.0330136596462305,-5.9391526437467,0.027328871709408,"TIMM17A","translocase of inner mitochondrial membrane 17 homolog A (yeast)",TRUE
+"1559909_a_at",0.671298718565642,0.137091206521212,1.54259755631275,-4.84270657915393,0.600485794076295,"TIMM17B","translocase of inner mitochondrial membrane 17 homolog B (yeast)",TRUE
+"203342_at",0.760273588173424,0.258666836528615,-1.15932178212187,-5.30543733006011,-0.410649091213095,"TIMM17B","translocase of inner mitochondrial membrane 17 homolog B (yeast)",TRUE
+"223180_s_at",0.64951423765686,0.120078462080211,-1.6167680260758,-4.74090965153968,-0.657930150996432,"TIMM21","translocase of inner mitochondrial membrane 21",TRUE
+"223181_at",0.834911598596338,0.413691634523519,-0.833077260247533,-5.60719092039094,-0.325645799032575,"TIMM21","translocase of inner mitochondrial membrane 21",TRUE
+"229100_s_at",0.635174103121116,0.106007814349525,-1.68508134625158,-4.64389655087528,-1.14036512233244,"TIMM22","translocase of inner mitochondrial membrane 22 homolog (yeast)",TRUE
+"219184_x_at",0.784708646973769,0.308609882555026,-1.04208533437144,-5.4241653561072,-0.405927849634415,"TIMM22","translocase of inner mitochondrial membrane 22 homolog (yeast)",TRUE
+"222841_s_at",0.95417470629735,0.78949994582873,-0.270209561179463,-5.90418387636636,-0.079448432030981,"TIMM22","translocase of inner mitochondrial membrane 22 homolog (yeast)",TRUE
+"224038_at",0.747904962117709,0.239808356486247,1.20793395948122,-5.25294741094943,0.715739413250463,"TIMM23","translocase of inner mitochondrial membrane 23",TRUE
+"229428_at",0.966313390701604,0.842892181630758,-0.200534134483343,-5.92011571289595,-0.0647123270433028,"TIMM23B","translocase of inner mitochondrial membrane 23 homolog B",TRUE
+"225535_s_at",0.80110325033185,0.337813046474406,-0.979696134686814,-5.48270765530595,-0.226611720821712,"TIMM23B///TIMM23","translocase of inner mitochondrial membrane 23 homolog B///translocase of inner mitochondrial membrane 23",TRUE
+"218118_s_at",0.928295253101366,0.685361609283683,-0.410527952919156,-5.85792888422807,-0.0918844339304439,"TIMM23B///TIMM23","translocase of inner mitochondrial membrane 23 homolog B///translocase of inner mitochondrial membrane 23",TRUE
+"218119_at",0.933548873991014,0.705889944567007,-0.382288185518335,-5.8687516019101,-0.117618912571034,"TIMM23B///TIMM23","translocase of inner mitochondrial membrane 23 homolog B///translocase of inner mitochondrial membrane 23",TRUE
+"203092_at",0.841088238127348,0.430933597786299,0.802242850449602,-5.63098225911928,0.37660402500466,"TIMM44","translocase of inner mitochondrial membrane 44",TRUE
+"203093_s_at",0.89390639630277,0.569829048609312,0.576890266342746,-5.77887485473411,0.180213960460062,"TIMM44","translocase of inner mitochondrial membrane 44",TRUE
+"224913_s_at",0.872070247187429,0.514932160223118,-0.661786923603771,-5.72859048399645,-0.23628527166427,"TIMM50","translocase of inner mitochondrial membrane 50",TRUE
+"217612_at",0.890943934856426,0.560068459826527,0.591658238100819,-5.77060577630913,0.199567240313037,"TIMM50","translocase of inner mitochondrial membrane 50",TRUE
+"205217_at",0.673190784310977,0.138724804299252,-1.53588403021421,-4.8517349183871,-0.610483276592092,"TIMM8A","translocase of inner mitochondrial membrane 8 homolog A (yeast)",TRUE
+"210800_at",0.954577684533304,0.792896553340788,-0.265739895013767,-5.9053466178837,-0.203968114246127,"TIMM8A","translocase of inner mitochondrial membrane 8 homolog A (yeast)",TRUE
+"218357_s_at",0.767011398042819,0.268292299784785,-1.13551894214062,-5.33044917979184,-0.358067596738072,"TIMM8B","translocase of inner mitochondrial membrane 8 homolog B",TRUE
+"223478_at",0.776936981479994,0.295293520771944,-1.07191945858349,-5.3950212934192,-0.394457126726961,"TIMM8B","translocase of inner mitochondrial membrane 8 homolog B",TRUE
+"218316_at",0.527546822913581,0.0402536459427296,-2.17887192719212,-3.85917679028886,-0.630424638349821,"TIMM9","translocase of inner mitochondrial membrane 9",TRUE
+"223004_s_at",0.933298127911264,0.704885466739236,-0.383662466857176,-5.86824250435171,-0.1036549650212,"TIMMDC1","translocase of inner mitochondrial membrane domain containing 1",TRUE
+"201666_at",0.936194651899263,0.71542907993882,0.369274026227512,-5.87348331425635,0.346036951363558,"TIMP1","TIMP metallopeptidase inhibitor 1",TRUE
+"203167_at",0.657015752622694,0.125188757215257,1.59361663347786,-4.77308490712099,1.94041467780208,"TIMP2","TIMP metallopeptidase inhibitor 2",TRUE
+"231579_s_at",0.695812999227098,0.165998081664766,1.43236325449741,-4.98693735320915,2.01541597345154,"TIMP2","TIMP metallopeptidase inhibitor 2",TRUE
+"224560_at",0.697713925841949,0.168662576476051,1.42300705556663,-4.99877923698403,2.58975344615971,"TIMP2","TIMP metallopeptidase inhibitor 2",TRUE
+"201147_s_at",0.6708432030569,0.136594763077009,1.54465082668617,-4.83993911871608,2.90245022813871,"TIMP3","TIMP metallopeptidase inhibitor 3",TRUE
+"201150_s_at",0.687786405532588,0.157118467400129,1.46444278533508,-4.9458550066992,2.71783859836695,"TIMP3","TIMP metallopeptidase inhibitor 3",TRUE
+"201149_s_at",0.729229845942426,0.211365588574091,1.28703595173471,-5.16356280409729,1.56042303934975,"TIMP3","TIMP metallopeptidase inhibitor 3",TRUE
+"201148_s_at",0.747771488910035,0.239634095400744,1.20839630973947,-5.25243917498263,1.33505704556152,"TIMP3","TIMP metallopeptidase inhibitor 3",TRUE
+"206243_at",0.0684692026559493,0.000187844177382577,4.47155266281387,0.817740906696434,3.52798443322479,"TIMP4","TIMP metallopeptidase inhibitor 4",TRUE
+"223782_s_at",0.809411730389276,0.352635734049197,0.94944623948354,-5.50990757737818,0.644826329262322,"TINAG","tubulointerstitial nephritis antigen",TRUE
+"240480_at",0.866807918403275,0.498297282797979,-0.688478777574102,-5.7114141857194,-0.547903124316825,"TINAG","tubulointerstitial nephritis antigen",TRUE
+"231154_x_at",0.997166163635587,0.985493802506611,0.0183881346131877,-5.93951879460328,0.0100261170692981,"TINAG","tubulointerstitial nephritis antigen",TRUE
+"219058_x_at",0.330914759325047,0.00803152968677344,2.9125651018967,-2.48379399938633,3.30022211246885,"TINAGL1","tubulointerstitial nephritis antigen like 1",TRUE
+"235994_s_at",0.693850056112024,0.16308319742952,1.44273798167403,-4.97373217833316,0.769492916270697,"TINCR","tissue differentiation-inducing non-protein coding RNA",TRUE
+"244374_at",0.860085676417428,0.479495590281444,0.719265449564255,-5.69079821690639,0.74233899905761,"TINCR","tissue differentiation-inducing non-protein coding RNA",TRUE
+"229385_s_at",0.983303501876831,0.918584409211984,-0.103388921592152,-5.93447847263114,-0.100303464618403,"TINCR","tissue differentiation-inducing non-protein coding RNA",TRUE
+"220052_s_at",0.516444287133032,0.0363144927802948,-2.2283814662541,-3.77328470997172,-0.903894771826518,"TINF2","TERF1 interacting nuclear factor 2",TRUE
+"224809_x_at",0.612420348961838,0.0843182177414242,-1.80727401357659,-4.4629070179694,-0.565388433285229,"TINF2","TERF1 interacting nuclear factor 2",TRUE
+"223776_x_at",0.614178202960275,0.0852110656794723,-1.80173765696795,-4.4713080600859,-0.580570217434605,"TINF2","TERF1 interacting nuclear factor 2",TRUE
+"212665_at",0.344817137069397,0.00870127305306683,2.87772047994366,-2.55330513442879,1.18187002819551,"TIPARP","TCDD inducible poly(ADP-ribose) polymerase",TRUE
+"1556829_at",0.632977954834093,0.10428680090741,1.6939548846702,-4.63107143678364,0.695526358341149,"TIPARP-AS1","TIPARP antisense RNA 1",TRUE
+"219258_at",0.849619613504567,0.450794037691836,-0.767658571509164,-5.65666246787515,-0.292302669688263,"TIPIN","TIMELESS interacting protein",TRUE
+"228619_x_at",0.855805293258105,0.469155044441247,0.736497168868836,-5.67888482547752,0.432661811043907,"TIPRL","TOR signaling pathway regulator",TRUE
+"214773_x_at",0.8920930097751,0.563220392179672,-0.586874925676782,-5.77330625145007,-0.233680602164572,"TIPRL","TOR signaling pathway regulator",TRUE
+"1554351_a_at",0.933815609540291,0.706771002539822,-0.381083378593927,-5.86919643647267,-0.120580206849437,"TIPRL","TOR signaling pathway regulator",TRUE
+"1553677_a_at",0.988713664405312,0.945675008323288,0.0689155651674582,-5.93737050970386,0.0254613223462474,"TIPRL","TOR signaling pathway regulator",TRUE
+"1552360_a_at",0.812302873476553,0.360358079727394,-0.934027219678752,-5.52347122227424,-0.36214058775669,"TIRAP","TIR domain containing adaptor protein",TRUE
+"239796_x_at",0.864549535575582,0.491880062243249,-0.698910291854172,-5.70452514503164,-0.295794421824555,"TIRAP","TIR domain containing adaptor protein",TRUE
+"1554091_a_at",0.958473780774099,0.811832113171441,-0.240920509812837,-5.91145250104498,-0.0784632507964851,"TIRAP","TIR domain containing adaptor protein",TRUE
+"1552804_a_at",0.991654201885031,0.960662139633973,0.0498835610757431,-5.9384715603058,0.014616652211604,"TIRAP","TIR domain containing adaptor protein",TRUE
+"221857_s_at",0.796327569283512,0.328624397727369,0.998907653595797,-5.4650297631221,0.403379981187486,"TJAP1","tight junction associated protein 1",TRUE
+"47608_at",0.877861946695164,0.529375295743924,0.638998125120307,-5.74273973405982,0.237106016420574,"TJAP1","tight junction associated protein 1",TRUE
+"202011_at",0.623667408398064,0.0948126877405905,1.74516010715238,-4.55607980082134,0.50794625510056,"TJP1","tight junction protein 1",TRUE
+"214168_s_at",0.698391916012681,0.169605822228254,1.41972332602276,-5.00292027709628,0.472186469750385,"TJP1","tight junction protein 1",TRUE
+"242991_at",0.78725170044443,0.313099880226278,1.03223183489083,-5.43362841367395,0.433618404012014,"TJP2","tight junction protein 2",TRUE
+"232017_at",0.8288884913487,0.399492791181444,0.859085212960112,-5.5864719366986,0.629195808462178,"TJP2","tight junction protein 2",TRUE
+"202085_at",0.947778780715578,0.761783060828857,-0.306902899303182,-5.89391114173951,-0.108453007675916,"TJP2","tight junction protein 2",TRUE
+"237132_at",0.987492202135276,0.94115412714266,-0.0746613807429705,-5.9369687988092,-0.0455622385094241,"TJP2","tight junction protein 2",TRUE
+"213412_at",0.654728282657457,0.12365814243067,-1.60046680408809,-4.76360224088041,-2.2452341311716,"TJP3","tight junction protein 3",TRUE
+"35148_at",0.741260241503758,0.231779158423001,-1.22950589646452,-5.22905531792836,-1.22650713495531,"TJP3","tight junction protein 3",TRUE
+"1554408_a_at",0.988737747949649,0.945795178105621,0.068762868647679,-5.93738074690238,0.02920733013773,"TK1","thymidine kinase 1",TRUE
+"202338_at",0.998870448604467,0.995528274212568,-0.0056680817454449,-5.93966783281064,-0.00254207688938735,"TK1","thymidine kinase 1",TRUE
+"240300_at",0.910165867297668,0.626431466376042,0.493620990403363,-5.82169666724042,0.305679829778411,"TK2","thymidine kinase 2, mitochondrial",TRUE
+"204276_at",0.963012049553072,0.83210934169247,0.214512597087191,-5.9172957721352,0.125048292038731,"TK2","thymidine kinase 2, mitochondrial",TRUE
+"204227_s_at",0.96696492045873,0.845877976359325,0.196670800509915,-5.92086170995175,0.0679319421631437,"TK2","thymidine kinase 2, mitochondrial",TRUE
+"204277_s_at",0.981836322577249,0.913055657949117,0.110438772982518,-5.9337446523709,0.0680548176997195,"TK2","thymidine kinase 2, mitochondrial",TRUE
+"218688_at",0.69385705848116,0.163302288587756,-1.44195302074574,-4.97473401368132,-0.75544143288624,"TKFC","triokinase and FMN cyclase",TRUE
+"244627_at",0.776123664575619,0.293656520330605,-1.07565282372679,-5.3913224247766,-0.4084849764232,"TKFC","triokinase and FMN cyclase",TRUE
+"228205_at",0.868397087637799,0.503516208027833,0.680051366340276,-5.71690742460484,0.527897712439728,"TKT","transketolase",TRUE
+"208699_x_at",0.919354071504066,0.656859537783478,-0.450313784626465,-5.8413953373504,-0.19752814073466,"TKT","transketolase",TRUE
+"208700_s_at",0.920853902082982,0.663486394488468,-0.44099969095421,-5.84540046058996,-0.20926614360077,"TKT","transketolase",TRUE
+"216370_s_at",0.846529455216068,0.444758248363023,-0.778068750512729,-5.64904469303348,-0.512641429715543,"TKTL1","transketolase like 1",TRUE
+"214183_s_at",0.966593471043185,0.844214712618099,0.198822523681642,-5.92044800290285,0.100221846590059,"TKTL1","transketolase like 1",TRUE
+"223829_at",0.867159108376357,0.499233054492228,0.686964044106476,-5.71240630003174,0.418440893193667,"TKTL2","transketolase like 2",TRUE
+"227804_at",0.923113737920869,0.670443515503374,0.431263857001854,-5.84949910295677,0.179328553640602,"TLCD1","TLC domain containing 1",TRUE
+"241359_at",0.924452121367105,0.673817108521205,0.426558099870629,-5.8514479416986,0.411412352178874,"TLCD2","TLC domain containing 2",TRUE
+"1557275_a_at",0.936963138658766,0.717678633450214,0.366214507130524,-5.87457222312767,0.375463734499543,"TLCD2","TLC domain containing 2",TRUE
+"233423_at",0.568731573107512,0.058705504200432,1.99311803534438,-4.17043322478802,2.38799183707662,"TLDC1","TBC/LysM-associated domain containing 1",TRUE
+"221843_s_at",0.653206225743412,0.122427949806493,1.60602390099041,-4.75588635537538,0.870251663294448,"TLDC1","TBC/LysM-associated domain containing 1",TRUE
+"222261_at",0.661974206478491,0.129377228035102,1.57522147325639,-4.79839214711949,0.80612089200436,"TLDC1","TBC/LysM-associated domain containing 1",TRUE
+"65438_at",0.70772084164277,0.179253068778665,1.38694976693052,-5.0438181193679,0.729774467112795,"TLDC1","TBC/LysM-associated domain containing 1",TRUE
+"236078_at",0.730101539866086,0.212822546395747,1.2827917728777,-5.16848181218226,0.706463805934277,"TLDC1","TBC/LysM-associated domain containing 1",TRUE
+"233829_at",0.994943851647199,0.976225623772739,0.0301395216650149,-5.93924104678435,0.0195049854483487,"TLDC2","TBC/LysM-associated domain containing 2",TRUE
+"227130_s_at",0.810322384577197,0.354081611155625,0.946542093406052,-5.51247783615051,0.470807965444814,"TLE1","transducin like enhancer of split 1",TRUE
+"203221_at",0.839519981963042,0.426513102084094,-0.810073529128043,-5.62501994558426,-0.445860124964023,"TLE1","transducin like enhancer of split 1",TRUE
+"203220_s_at",0.932411919177942,0.701698785813945,-0.388027338889285,-5.86661361017243,-0.163005691166632,"TLE1","transducin like enhancer of split 1",TRUE
+"203222_s_at",0.968066640321622,0.850174003823669,-0.191117502593834,-5.92190870454691,-0.157436707169762,"TLE1","transducin like enhancer of split 1",TRUE
+"228284_at",0.997325121479245,0.986467670708631,-0.0171535228934322,-5.9395401666793,-0.00773905547386811,"TLE1","transducin like enhancer of split 1",TRUE
+"40837_at",0.808257777979515,0.350834068986855,-0.953076303507323,-5.50668471547475,-0.659384693677236,"TLE2","transducin like enhancer of split 2",TRUE
+"204431_at",0.91339551560427,0.636945879549298,-0.478551936590111,-5.82875159021425,-0.325406226012902,"TLE2","transducin like enhancer of split 2",TRUE
+"212769_at",0.553930058946379,0.0506768752601699,-2.06638107719126,-4.04981628735644,-0.928122400665501,"TLE3","transducin like enhancer of split 3",TRUE
+"206472_s_at",0.783033755750449,0.305524288189363,-1.04891567296082,-5.4175581960287,-0.545078176663203,"TLE3","transducin like enhancer of split 3",TRUE
+"228340_at",0.825648186672984,0.393202873980661,-0.870795972491203,-5.57694904071475,-0.621355758976955,"TLE3","transducin like enhancer of split 3",TRUE
+"212770_at",0.922168942129244,0.667608085598897,-0.435226606718501,-5.84784168479953,-0.405522488016528,"TLE3","transducin like enhancer of split 3",TRUE
+"214688_at",0.564144814478888,0.0559797774586336,2.01693164169418,-4.13154430793493,1.12137579991855,"TLE4","transducin like enhancer of split 4",TRUE
+"233575_s_at",0.584828007864693,0.0649878220693397,1.94175993331406,-4.25323971020309,2.88384077426602,"TLE4","transducin like enhancer of split 4",TRUE
+"216997_x_at",0.627053909308516,0.0977762434476546,1.72869095462526,-4.58038098354861,2.74926299156884,"TLE4","transducin like enhancer of split 4",TRUE
+"204872_at",0.714813484380156,0.190548736169325,1.35031123122109,-5.08859982775726,1.68083433501199,"TLE4","transducin like enhancer of split 4",TRUE
+"235765_at",0.737488397392592,0.223735580195172,1.25169281868731,-5.20410184456026,1.32658618209,"TLE4","transducin like enhancer of split 4",TRUE
+"222219_s_at",0.771623843789204,0.281029312837489,1.10496597891083,-5.36188187681876,0.43061481432738,"TLE6","transducin like enhancer of split 6",TRUE
+"1553813_s_at",0.915078108213431,0.642153028915097,-0.471130780226633,-5.83214735626978,-0.177957085015622,"TLE6","transducin like enhancer of split 6",TRUE
+"1553812_at",0.941952420964607,0.739300157875349,0.336983996185088,-5.88452431138263,0.143378521329097,"TLE6","transducin like enhancer of split 6",TRUE
+"202606_s_at",0.592518526795544,0.0696292448701346,-1.90655860140004,-4.30913824269807,-0.512217020026236,"TLK1","tousled like kinase 1",TRUE
+"222966_at",0.705100208997726,0.176920034289992,1.39474413874816,-5.03416306711488,1.27754984750141,"TLK1","tousled like kinase 1",TRUE
+"210379_s_at",0.718706241731185,0.194728328169691,-1.33718808258941,-5.10439588106127,-0.768984505939887,"TLK1","tousled like kinase 1",TRUE
+"211077_s_at",0.822850703882235,0.388577360033886,-0.879485475442534,-5.56980554414952,-0.50839886336912,"TLK1","tousled like kinase 1",TRUE
+"241643_at",0.884221189678062,0.543163289922769,-0.617556418517889,-5.75561716673819,-0.534424473435883,"TLK1","tousled like kinase 1",TRUE
+"241642_x_at",0.96200396340887,0.827355233123068,0.220689387120024,-5.91598945508902,0.19773508708204,"TLK1","tousled like kinase 1",TRUE
+"244389_at",0.96927731102763,0.854253277322467,-0.185850082497097,-5.9228741860995,-0.056614861184026,"TLK1","tousled like kinase 1",TRUE
+"228627_at",0.854040699678541,0.463335547090913,-0.746293605789284,-5.67199260886662,-0.297951906211612,"TLK2","tousled like kinase 2",TRUE
+"212986_s_at",0.896118635245982,0.578394639570179,-0.564036337179187,-5.78590740049667,-0.202799597100846,"TLK2","tousled like kinase 2",TRUE
+"212997_s_at",0.960553258945741,0.820708650967541,-0.229339779883387,-5.91409797122312,-0.0935082555596143,"TLK2","tousled like kinase 2",TRUE
+"232585_at",0.971242929121865,0.863679712088436,-0.173698355896317,-5.92499891648942,-0.129454698039062,"TLK2","tousled like kinase 2",TRUE
+"206415_at",0.369623435296638,0.0110480286809365,2.77305702341181,-2.75999901310941,2.41383625654581,"TLL1","tolloid like 1",TRUE
+"1555071_at",0.806649582904638,0.347795526778839,0.959227208651005,-5.50119808998804,0.63030071018965,"TLL1","tolloid like 1",TRUE
+"215008_at",0.412728274083545,0.0165563644271355,2.59270678603967,-3.10801153787589,0.981842529609961,"TLL2","tolloid like 2",TRUE
+"208027_s_at",0.93527815307551,0.712203605385609,0.373667134673791,-5.8719041350132,0.373298443469514,"TLL2","tolloid like 2",TRUE
+"215843_s_at",0.952697366942815,0.78371142088834,-0.277839832997443,-5.90215444043974,-0.164591252828845,"TLL2","tolloid like 2",TRUE
+"203254_s_at",0.683449004637821,0.15244006605502,1.48193872534107,-4.92313823774565,0.708804856976364,"TLN1","talin 1",TRUE
+"236132_at",0.861405172272497,0.481985851933306,0.715148194292525,-5.69360504445562,0.282969445148166,"TLN1","talin 1",TRUE
+"232763_at",0.94632739401154,0.757272388275729,0.312913946025454,-5.89210483210425,0.208272624022087,"TLN1","talin 1",TRUE
+"232625_at",0.647518308302168,0.118516247636995,1.6240097291482,-4.73077158510078,0.558942708322832,"TLN2","talin 2",TRUE
+"212701_at",0.674303263287064,0.140681798341391,-1.52792658517397,-4.86239560074814,-1.38357012382731,"TLN2","talin 2",TRUE
+"212703_at",0.805168768064335,0.344451714403746,-0.966038435562372,-5.49508480152375,-0.835860802649075,"TLN2","talin 2",TRUE
+"210176_at",0.0681210092794308,0.000184894272724263,4.47801120928654,0.83167372639276,3.31664853626648,"TLR1","toll like receptor 1",TRUE
+"223751_x_at",0.429960090499345,0.0190346941989789,2.52949865171902,-3.22728344641732,1.47366486727045,"TLR10","toll like receptor 10",TRUE
+"223750_s_at",0.75235436509186,0.245689242796147,1.19247686497304,-5.26984125335148,0.935941508006079,"TLR10","toll like receptor 10",TRUE
+"204924_at",0.42537276038623,0.0180356684061886,2.55399496507764,-3.18123593349031,2.06717324370804,"TLR2","toll like receptor 2",TRUE
+"239587_at",0.51470556386048,0.0353755928046286,2.24090102941853,-3.75137973551428,2.04050303148054,"TLR3","toll like receptor 3",TRUE
+"206271_at",0.51531387545335,0.0359687680746686,2.23295679003837,-3.76528801982236,2.31600469166131,"TLR3","toll like receptor 3",TRUE
+"242667_at",0.778955753047799,0.299956733875964,1.06136497857598,-5.40541597237286,0.908618997151286,"TLR3","toll like receptor 3",TRUE
+"221060_s_at",0.73223722457785,0.215969264778528,1.27370116406436,-5.17897123584537,0.465852969749609,"TLR4","toll like receptor 4",TRUE
+"232068_s_at",0.734916299478162,0.219970832024876,1.26228700198901,-5.19205149953552,1.28236139768337,"TLR4","toll like receptor 4",TRUE
+"1552798_a_at",0.945722406772716,0.754917397735499,-0.316056938004933,-5.89114655062593,-0.114921601615309,"TLR4","toll like receptor 4",TRUE
+"224341_x_at",0.993225426079816,0.968446470193586,-0.0400062201444358,-5.93890396741962,-0.033228138742436,"TLR4","toll like receptor 4",TRUE
+"210166_at",0.872238421308015,0.5151717877798,0.661405977052043,-5.72883091700259,0.278507858870919,"TLR5","toll like receptor 5",TRUE
+"207446_at",0.0823353801878483,0.000298631427486941,4.28244752574602,0.409360704113092,2.44819221927582,"TLR6","toll like receptor 6",TRUE
+"239021_at",0.429284714913652,0.0189501009185554,2.53152576377648,-3.22348154242162,2.04397363956072,"TLR6","toll like receptor 6",TRUE
+"222952_s_at",0.89395381756398,0.57014112740111,-0.576420232343212,-5.7791347202641,-0.37611587667006,"TLR7","toll like receptor 7",TRUE
+"220146_at",0.897011777275924,0.582292566687072,-0.558218690486191,-5.78903979678255,-0.532272098779226,"TLR7","toll like receptor 7",TRUE
+"229560_at",0.683838837468118,0.152839699933432,1.4804272993163,-4.92510927410409,0.951864742685265,"TLR8","toll like receptor 8",TRUE
+"220832_at",0.710739561811938,0.183956105898399,1.37147923761739,-5.06284879934494,0.894259818982095,"TLR8","toll like receptor 8",TRUE
+"1562805_at",0.999639752011996,0.999205344668105,-0.00100725026190638,-5.93968298659771,-0.000712456262068173,"TLR8-AS1","TLR8 antisense RNA 1",TRUE
+"223903_at",0.692948460442636,0.162302311813441,1.44554267376178,-4.97014895494344,0.504398089550876,"TLR9","toll like receptor 9",TRUE
+"207179_at",0.912051899719319,0.631571961138969,0.486239469610823,-5.82517920623024,0.222536059359838,"TLX1","T-cell leukemia homeobox 1",TRUE
+"1560883_s_at",0.883124212410502,0.540890361243539,0.6210707705665,-5.75353552012206,0.224135534630997,"TLX1NB","TLX1 neighbor",TRUE
+"211049_at",0.662575055303091,0.130422524507579,1.57070792434087,-4.8045665446125,0.907344575663849,"TLX2","T-cell leukemia homeobox 2",TRUE
+"207410_s_at",0.680586794685785,0.148294234078211,1.49781179208958,-4.90234059028827,0.786435254733688,"TLX2","T-cell leukemia homeobox 2",TRUE
+"208495_at",0.734042693548791,0.218383738246502,1.26679482738988,-5.18689770458337,0.885961867598516,"TLX3","T-cell leukemia homeobox 3",TRUE
+"213882_at",0.663252754612157,0.131202087191607,-1.56736128896591,-4.80913566408374,-0.646420666695257,"TM2D1","TM2 domain containing 1",TRUE
+"1558802_at",0.711427723123186,0.185070199038854,1.36786042998166,-5.0672747676102,0.607381634318736,"TM2D1","TM2 domain containing 1",TRUE
+"212963_at",0.778397054392363,0.29816971704636,-1.06539567968061,-5.40145716925591,-0.347874123200837,"TM2D1","TM2 domain containing 1",TRUE
+"213883_s_at",0.818895116503733,0.372843881470086,-0.909558684322763,-5.54457596833448,-0.272645061988692,"TM2D1","TM2 domain containing 1",TRUE
+"211703_s_at",0.971735822349954,0.86488326782532,0.172148802648208,-5.92525956210146,0.0518783888438943,"TM2D1","TM2 domain containing 1",TRUE
+"224413_s_at",0.953270403278023,0.785041388783975,-0.276085231824611,-5.90262608146719,-0.134960693637961,"TM2D2","TM2 domain containing 2",TRUE
+"221702_s_at",0.826140850652187,0.394229682126267,-0.868876008678073,-5.57851852324464,-0.30498504707827,"TM2D3","TM2 domain containing 3",TRUE
+"1552426_a_at",0.937985925753626,0.725667428869732,-0.35537778575054,-5.87835714626085,-0.137002413858484,"TM2D3","TM2 domain containing 3",TRUE
+"215033_at",0.646224068018448,0.117178655296087,1.63027402136189,-4.7219736747442,1.69307428809384,"TM4SF1","transmembrane 4 L six family member 1",TRUE
+"209387_s_at",0.755598961025524,0.24958604912887,1.18238684581482,-5.2807669317069,1.70723896958731,"TM4SF1","transmembrane 4 L six family member 1",TRUE
+"215034_s_at",0.756601922352523,0.252047233095559,1.17607458768003,-5.28756076839336,1.97224050806349,"TM4SF1","transmembrane 4 L six family member 1",TRUE
+"209386_at",0.765400039004994,0.265671455919,1.14193684796743,-5.32375026627843,1.68873845003887,"TM4SF1","transmembrane 4 L six family member 1",TRUE
+"238168_at",0.921312278448293,0.664551581147357,-0.439506275661942,-5.84603499842546,-0.301433122890229,"TM4SF1","transmembrane 4 L six family member 1",TRUE
+"230061_at",0.630603891142543,0.101735076041692,1.70734314286897,-4.61162520900085,2.1773141608532,"TM4SF18","transmembrane 4 L six family member 18",TRUE
+"228489_at",0.91704891241952,0.648900122655135,0.461554618445237,-5.83645242399325,0.525353535626983,"TM4SF18","transmembrane 4 L six family member 18",TRUE
+"220639_at",0.413584432973372,0.0166544013851909,2.59004288065385,-3.11306794993468,1.92266841228422,"TM4SF20","transmembrane 4 L six family member 20",TRUE
+"209937_at",0.855280328719381,0.467717099838749,-0.738911044797262,-5.67719457845229,-0.384007558002813,"TM4SF4","transmembrane 4 L six family member 4",TRUE
+"206242_at",0.755483862926893,0.249494147492795,1.18262344617834,-5.280511663142,0.770201150374484,"TM4SF5","transmembrane 4 L six family member 5",TRUE
+"219892_at",0.299994279961527,0.00560198020244898,3.06784603952255,-2.17017369302886,1.54424988816246,"TM6SF1","transmembrane 6 superfamily member 1",TRUE
+"234092_s_at",0.587626678796111,0.0667514115061295,1.9281317573859,-4.27496458840525,1.15838206052505,"TM6SF2","transmembrane 6 superfamily member 2",TRUE
+"216736_at",0.812302873476553,0.360683137474559,0.93338308016321,-5.52403341464364,0.431953885989078,"TM6SF2","transmembrane 6 superfamily member 2",TRUE
+"233403_x_at",0.830635993561085,0.404213584998982,0.850373601306994,-5.59347812095278,0.486077650727072,"TM6SF2","transmembrane 6 superfamily member 2",TRUE
+"210130_s_at",0.867372060429555,0.49968463278814,-0.686233651208632,-5.71288394392421,-0.782222788485093,"TM7SF2","transmembrane 7 superfamily member 2",TRUE
+"217974_at",0.571677937624457,0.0595326879185842,1.98608537271944,-4.18185866898154,1.04502104915216,"TM7SF3","transmembrane 7 superfamily member 3",TRUE
+"226478_at",0.661974206478491,0.12982806430853,1.57327108396419,-4.80106192457068,0.694833538430677,"TM7SF3","transmembrane 7 superfamily member 3",TRUE
+"222477_s_at",0.860714927752408,0.480341309508388,0.717865792654379,-5.69175411514595,0.375451137651563,"TM7SF3","transmembrane 7 superfamily member 3",TRUE
+"209149_s_at",0.744931128252932,0.236497353601131,-1.21676241757541,-5.24321365864852,-0.467848479888215,"TM9SF1","transmembrane 9 superfamily member 1",TRUE
+"238948_at",0.959357995170594,0.816340755133747,0.23503422524555,-5.91281334372748,0.0714957861071319,"TM9SF1","transmembrane 9 superfamily member 1",TRUE
+"201078_at",0.936599157163462,0.71691761806352,-0.367249130786484,-5.87420499243337,-0.15609856520144,"TM9SF2","transmembrane 9 superfamily member 2",TRUE
+"239626_x_at",0.89967769475675,0.591099385802032,0.545145492637731,-5.79596376375184,0.257034544553418,"TM9SF3","transmembrane 9 superfamily member 3",TRUE
+"222399_s_at",0.916349280948806,0.646827867566008,-0.464491073201704,-5.8351415121467,-0.163649338916796,"TM9SF3","transmembrane 9 superfamily member 3",TRUE
+"217758_s_at",0.93950030622033,0.729005922402875,-0.35086204511501,-5.879901202329,-0.116607765438214,"TM9SF3","transmembrane 9 superfamily member 3",TRUE
+"228610_at",0.97070558355376,0.86035193019625,0.1779850856104,-5.92426572677563,0.058367012928854,"TM9SF3","transmembrane 9 superfamily member 3",TRUE
+"224755_at",0.99240560748784,0.964617722421314,-0.0448638494325821,-5.93870318468432,-0.0200976637722405,"TM9SF3","transmembrane 9 superfamily member 3",TRUE
+"212198_s_at",0.708894565317004,0.181102589903367,1.38082783896104,-5.05137004013884,0.414924885472175,"TM9SF4","transmembrane 9 superfamily member 4",TRUE
+"212194_s_at",0.792436690618566,0.3239549202866,1.00881327053991,-5.45579314033083,0.3713717148181,"TM9SF4","transmembrane 9 superfamily member 4",TRUE
+"218513_at",0.832741974897873,0.409513781526149,-0.840669957539711,-5.60120371567853,-0.385217374031463,"TMA16","translation machinery associated 16 homolog",TRUE
+"221791_s_at",0.866602763987519,0.497744520713258,-0.689374293225759,-5.71082666253998,-0.162643841556406,"TMA7","translation machinery associated 7 homolog",TRUE
+"223892_s_at",0.567292616148537,0.0572004223598083,-2.00614279572584,-4.14920132867634,-0.758468075697907,"TMBIM4","transmembrane BAX inhibitor motif containing 4",TRUE
+"222845_x_at",0.597654932724127,0.0739954122974577,-1.87527624947181,-4.35821493883325,-0.728957655783999,"TMBIM4","transmembrane BAX inhibitor motif containing 4",TRUE
+"219206_x_at",0.607377668936197,0.0809620413965526,-1.82854928866115,-4.43045034109731,-0.663905196639323,"TMBIM4","transmembrane BAX inhibitor motif containing 4",TRUE
+"1563222_at",0.748438284778152,0.241105555250934,-1.20450015509531,-5.2567167195394,-0.724552477117126,"TMBIM4","transmembrane BAX inhibitor motif containing 4",TRUE
+"200804_at",0.725168361556674,0.203455948872685,-1.31048068532707,-5.1361419018435,-0.433572303388347,"TMBIM6","transmembrane BAX inhibitor motif containing 6",TRUE
+"200803_s_at",0.776954388941225,0.295437971683756,-1.07159073422722,-5.39534642947359,-0.378763998803151,"TMBIM6","transmembrane BAX inhibitor motif containing 6",TRUE
+"1564591_a_at",0.737161440695888,0.223258277977517,1.25302838314287,-5.20258750615837,0.925210073868137,"TMC1","transmembrane channel like 1",TRUE
+"1553019_at",0.527546822913581,0.0399023046026771,2.18310481582863,-3.85187963681966,1.081791651144,"TMC2","transmembrane channel like 2",TRUE
+"238247_at",0.854040699678541,0.463196398929995,0.746528737813163,-5.67182612250942,0.284268332418774,"TMC3-AS1","TMC3 antisense RNA 1",TRUE
+"226403_at",0.755049574909504,0.248622261917528,-1.18487135702294,-5.27808416504806,-1.04909187715448,"TMC4","transmembrane channel like 4",TRUE
+"236983_at",0.748760747870936,0.241857703665947,1.20251551332428,-5.25889102478526,0.672749079055084,"TMC5","transmembrane channel like 5",TRUE
+"240304_s_at",0.769258076576208,0.276163085252981,1.11651721731116,-5.35008728145485,1.76066962629107,"TMC5","transmembrane channel like 5",TRUE
+"240303_at",0.78187900363728,0.303388644881053,1.05367185749016,-5.41293451058641,0.799991337004935,"TMC5","transmembrane channel like 5",TRUE
+"222904_s_at",0.789795896476304,0.318383828517746,1.02076248936379,-5.44454112646584,0.990770088091771,"TMC5","transmembrane channel like 5",TRUE
+"219580_s_at",0.821424121108148,0.383037096629918,0.889982533293162,-5.5610883648849,1.00490843666532,"TMC5","transmembrane channel like 5",TRUE
+"204328_at",0.933859583363678,0.70693384474759,0.380860762169565,-5.86927847857079,0.219836384245747,"TMC6","transmembrane channel like 6",TRUE
+"214958_s_at",0.993255118943385,0.968566802406685,0.0398535682330054,-5.93890990462789,0.0202279669877203,"TMC6","transmembrane channel like 6",TRUE
+"220021_at",0.869715052099024,0.507353664137145,-0.673886149333965,-5.72088511505106,-0.25275654015777,"TMC7","transmembrane channel like 7",TRUE
+"1561030_at",0.975552150564853,0.883532430202755,0.148190987701504,-5.92899295443844,0.138701392167278,"TMC7","transmembrane channel like 7",TRUE
+"242644_at",0.842917136850585,0.436714587272025,0.792076877773939,-5.63864145685371,0.57856588380552,"TMC8","transmembrane channel like 8",TRUE
+"227353_at",0.890889721009079,0.559973175876619,0.591803055768642,-5.77052368724133,0.469930482771455,"TMC8","transmembrane channel like 8",TRUE
+"236554_x_at",0.92070400963176,0.662529477044462,0.442342179768826,-5.84482824701359,0.338524809265915,"TMC8","transmembrane channel like 8",TRUE
+"239029_at",0.901892339532073,0.599991404952905,0.532042586684902,-5.80274343147416,0.305686315139411,"TMCC1","transmembrane and coiled-coil domain family 1",TRUE
+"213351_s_at",0.912722788750542,0.634155723654513,0.482539647898964,-5.82690545569269,0.297580289999757,"TMCC1","transmembrane and coiled-coil domain family 1",TRUE
+"237943_at",0.936992192746977,0.719090791688639,-0.364295712337628,-5.87525057541535,-0.29246505177753,"TMCC1","transmembrane and coiled-coil domain family 1",TRUE
+"213349_at",0.946727564264032,0.758473050529433,-0.311312770266985,-5.89258937436353,-0.212612285122173,"TMCC1","transmembrane and coiled-coil domain family 1",TRUE
+"239662_x_at",0.947778780715578,0.761543702815202,0.307221582636875,-5.89381624937275,0.163572215761382,"TMCC1","transmembrane and coiled-coil domain family 1",TRUE
+"227112_at",0.957571530817866,0.809222427939059,-0.24433156658129,-5.91064858474665,-0.112049039071806,"TMCC1","transmembrane and coiled-coil domain family 1",TRUE
+"213352_at",0.977930820766623,0.893464312948532,0.135468963044505,-5.9307489271855,0.0784620733242516,"TMCC1","transmembrane and coiled-coil domain family 1",TRUE
+"1558480_at",0.763044089435492,0.262787388665745,-1.14905341550114,-5.31628323096911,-1.10680521875343,"TMCC1-AS1","TMCC1 antisense RNA 1 (head to head)",TRUE
+"1558481_s_at",0.996366493108774,0.982251851905735,0.0224983073022206,-5.9394369451455,0.00917736965452587,"TMCC1-AS1","TMCC1 antisense RNA 1 (head to head)",TRUE
+"1555503_a_at",0.637485146909712,0.108590883361785,1.67198942294787,-4.6627255287241,0.981495831131306,"TMCC2","transmembrane and coiled-coil domain family 2",TRUE
+"213096_at",0.721094750464234,0.19725105563342,1.32937375078531,-5.1137402830306,0.62099085003016,"TMCC2","transmembrane and coiled-coil domain family 2",TRUE
+"235146_at",0.798737990058781,0.333300543999837,0.989085161938803,-5.47410714509514,0.785556334609423,"TMCC3","transmembrane and coiled-coil domain family 3",TRUE
+"226489_at",0.861365125317687,0.481860333296146,0.715355422902937,-5.69346413839895,0.551817115932169,"TMCC3","transmembrane and coiled-coil domain family 3",TRUE
+"210768_x_at",0.910888708415045,0.628517373821051,-0.490622390647732,-5.82311756408526,-0.461545323433461,"TMCO1","transmembrane and coiled-coil domains 1",TRUE
+"211098_x_at",0.931398124704888,0.69682377466558,-0.394719671586665,-5.86408088522951,-0.436735888461163,"TMCO1","transmembrane and coiled-coil domains 1",TRUE
+"208716_s_at",0.9802233499944,0.907329114733195,0.117746888405424,-5.93293293223885,0.176043546735288,"TMCO1","transmembrane and coiled-coil domains 1",TRUE
+"208715_at",0.995111934465262,0.977511517588583,0.0285088789334388,-5.93928762493424,0.0231515026470728,"TMCO1","transmembrane and coiled-coil domains 1",TRUE
+"231264_at",0.969603512618622,0.854864880215467,0.185060808895925,-5.92301653790847,0.124217331222444,"TMCO2","transmembrane and coiled-coil domains 2",TRUE
+"220241_at",0.478602853563251,0.0267159745601288,2.3733494658524,-3.5152542245235,0.940895577566601,"TMCO3","transmembrane and coiled-coil domains 3",TRUE
+"220240_s_at",0.712948021516228,0.186916860952175,1.36189983220781,-5.07454360964699,0.673721131265069,"TMCO3","transmembrane and coiled-coil domains 3",TRUE
+"226050_at",0.720018659171833,0.195963669059578,1.33335168150168,-5.10898921411047,0.617070803983495,"TMCO3","transmembrane and coiled-coil domains 3",TRUE
+"230317_x_at",0.904832003218088,0.610012960606557,-0.517387245459284,-5.81013614069939,-0.347660744117559,"TMCO3","transmembrane and coiled-coil domains 3",TRUE
+"227007_at",0.85629081478032,0.470192558758891,0.7347582105377,-5.68009922864287,0.643338551356771,"TMCO4","transmembrane and coiled-coil domains 4",TRUE
+"1560292_a_at",0.986342822130003,0.933380565583232,0.0845473286085901,-5.93620243100175,0.0839588940689229,"TMCO4","transmembrane and coiled-coil domains 4",TRUE
+"1560184_at",0.536422380101288,0.0432655077545383,2.14389762126791,-3.91913214984268,1.78988796929211,"TMCO5A","transmembrane and coiled-coil domains 5A",TRUE
+"1553637_s_at",0.843816788557882,0.43960401755755,0.787026840444201,-5.6424120586946,0.24548413354233,"TMCO5A","transmembrane and coiled-coil domains 5A",TRUE
+"1553636_at",0.986183732366864,0.932401764014682,0.0857927008745522,-5.93609914312846,0.0463348045201548,"TMCO5A","transmembrane and coiled-coil domains 5A",TRUE
+"243406_at",0.951893068371814,0.779524062873509,0.283369985582422,-5.90064852008067,0.136618415957626,"TMCO5B","transmembrane and coiled-coil domains 5B (pseudogene)",TRUE
+"221096_s_at",0.735677568529031,0.220748597585473,1.26008701558465,-5.19456103210062,0.455685377571015,"TMCO6","transmembrane and coiled-coil domains 6",TRUE
+"213550_s_at",0.969642324744141,0.855213833398954,-0.184610538701214,-5.9230974772407,-0.0853354658580221,"TMCO6///IK","transmembrane and coiled-coil domains 6///IK cytokine, down-regulator of HLA II",TRUE
+"203679_at",0.819018525257656,0.374161903157641,0.90700770679606,-5.54674651602751,0.428387025175065,"TMED1","transmembrane p24 trafficking protein 1",TRUE
+"200929_at",0.700061364939874,0.171837765295472,-1.41201110744449,-5.01261507969858,-0.585709471087895,"TMED10","transmembrane p24 trafficking protein 10",TRUE
+"212352_s_at",0.774230543658252,0.28948241317567,-1.08524040743476,-5.38177081698888,-0.290341070034014,"TMED10","transmembrane p24 trafficking protein 10",TRUE
+"238886_at",0.93613089056626,0.714625525846826,0.370367774326626,-5.87309187048724,0.265492418220658,"TMED10","transmembrane p24 trafficking protein 10",TRUE
+"200087_s_at",0.834881450121645,0.413447859847485,-0.833518950044452,-5.60684401775029,-0.225227063191671,"TMED2","transmembrane p24 trafficking protein 2",TRUE
+"204426_at",0.836221360949212,0.417490643501678,-0.826215069852775,-5.61255838010429,-0.374441638504086,"TMED2","transmembrane p24 trafficking protein 2",TRUE
+"204427_s_at",0.837067957688307,0.419203712298221,-0.823133611127306,-5.61495511201589,-0.425780498643475,"TMED2","transmembrane p24 trafficking protein 2",TRUE
+"208837_at",0.522403182336918,0.0381824982002748,-2.2043252950551,-3.81516605972941,-1.00668010280288,"TMED3","transmembrane p24 trafficking protein 3",TRUE
+"239613_at",0.571830403845452,0.0598552428204394,1.98336648796547,-4.18626854649946,1.59977325976724,"TMED3","transmembrane p24 trafficking protein 3",TRUE
+"242928_at",0.697699759202153,0.168420495857178,-1.42385218660102,-4.9977121907949,-0.797068921834049,"TMED3","transmembrane p24 trafficking protein 3",TRUE
+"239115_at",0.820611742812032,0.380898086105896,0.894061851592672,-5.55767488710333,0.50486354537024,"TMED3","transmembrane p24 trafficking protein 3",TRUE
+"1558487_a_at",0.700240798541278,0.171992806085819,1.41147836568718,-5.01328317018948,0.481439809799834,"TMED4","transmembrane p24 trafficking protein 4",TRUE
+"1558053_s_at",0.808257777979515,0.350900900609878,-0.952941423431233,-5.50680466687335,-0.42706114587797,"TMED4","transmembrane p24 trafficking protein 4",TRUE
+"224680_at",0.859502367311367,0.477231910363579,-0.723018921080326,-5.68822603534883,-0.220013709438167,"TMED4","transmembrane p24 trafficking protein 4",TRUE
+"1558052_at",0.897949253801113,0.586267467720575,-0.552306143826125,-5.79219099644379,-0.176035316619875,"TMED4","transmembrane p24 trafficking protein 4",TRUE
+"224676_at",0.991367768700244,0.959835334498053,0.0509329544947729,-5.93842003719424,0.0212053602093132,"TMED4","transmembrane p24 trafficking protein 4",TRUE
+"239283_at",0.680708651141727,0.148641560573257,1.49646820163329,-4.90410792456168,0.735814972732331,"TMED5","transmembrane p24 trafficking protein 5",TRUE
+"1558814_s_at",0.841967750949524,0.434857599290329,0.795333314568214,-5.63619800808274,0.245658696039958,"TMED5","transmembrane p24 trafficking protein 5",TRUE
+"202195_s_at",0.871744769522775,0.513895290312768,0.663436417693791,-5.72754788073836,0.251470012058702,"TMED5","transmembrane p24 trafficking protein 5",TRUE
+"242263_at",0.92051722798026,0.661924010263606,0.44319203432852,-5.84446512841134,0.242710637451507,"TMED5","transmembrane p24 trafficking protein 5",TRUE
+"1558813_at",0.93763407082406,0.724099524721977,-0.35750117318052,-5.87762435893987,-0.341715397766586,"TMED5","transmembrane p24 trafficking protein 5",TRUE
+"202194_at",0.959203345279235,0.815065479671329,0.236698298712955,-5.91243202302137,0.0871530083956529,"TMED5","transmembrane p24 trafficking protein 5",TRUE
+"236430_at",0.741186481976394,0.231483221367882,1.23031172916388,-5.22815573390795,1.07371349579165,"TMED6","transmembrane p24 trafficking protein 6",TRUE
+"239431_at",0.937623890519979,0.723888717833135,0.357786793134831,-5.877525461628,0.221181729630638,"TMED7-TICAM2///TICAM2","TMED7-TICAM2 readthrough///toll like receptor adaptor molecule 2",TRUE
+"228234_at",0.966593471043185,0.844411102735745,0.198568408835281,-5.92049709454075,0.10258520128353,"TMED7-TICAM2///TICAM2","TMED7-TICAM2 readthrough///toll like receptor adaptor molecule 2",TRUE
+"214658_at",0.931582451098271,0.698150473971807,-0.392896596276643,-5.86477506001111,-0.14944213373551,"TMED7-TICAM2///TMED7","TMED7-TICAM2 readthrough///transmembrane p24 trafficking protein 7",TRUE
+"209404_s_at",0.978257169730337,0.895190167127184,-0.133260661772575,-5.93103771663847,-0.0657005802287873,"TMED7-TICAM2///TMED7","TMED7-TICAM2 readthrough///transmembrane p24 trafficking protein 7",TRUE
+"225343_at",0.552420073963858,0.0499724063071172,-2.07329472216664,-4.03828655644861,-0.772401451556764,"TMED8","transmembrane p24 trafficking protein family member 8",TRUE
+"242617_at",0.726480797733202,0.205496969459641,-1.30436418858,-5.14333619352243,-0.525767177846893,"TMED8","transmembrane p24 trafficking protein family member 8",TRUE
+"232913_at",0.895370220688938,0.573847547269918,-0.570847824544699,-5.78219987592248,-0.182534130043795,"TMED8","transmembrane p24 trafficking protein family member 8",TRUE
+"205812_s_at",0.930065981387326,0.691335621590339,0.402275750128184,-5.86117000526885,0.119161775045036,"TMED9","transmembrane p24 trafficking protein 9",TRUE
+"208757_at",0.933993359946081,0.707460466553398,0.380140968264959,-5.86954342476963,0.112723735994571,"TMED9","transmembrane p24 trafficking protein 9",TRUE
+"233910_at",0.83872852514497,0.424158092734493,-0.814265954693192,-5.62180547563908,-0.600788237736999,"TMEFF2","transmembrane protein with EGF like and two follistatin like domains 2",TRUE
+"224321_at",0.968066640321622,0.849901960555567,0.191468977534907,-5.92184332470806,0.116178003035818,"TMEFF2","transmembrane protein with EGF like and two follistatin like domains 2",TRUE
+"223557_s_at",0.998047179825832,0.991294151452532,-0.0110351649749447,-5.9396241688757,-0.0129307369884701,"TMEFF2","transmembrane protein with EGF like and two follistatin like domains 2",TRUE
+"219230_at",0.816800680706682,0.367905980982864,0.919169294438121,-5.53634810691601,0.679450504479921,"TMEM100","transmembrane protein 100",TRUE
+"225004_at",0.728385463227073,0.209248119983128,1.29324471565699,-5.15634194972846,1.19462239367937,"TMEM101","transmembrane protein 101",TRUE
+"230633_at",0.774230543658252,0.28630371341725,1.09260856180318,-5.37437895356981,0.5674466054433,"TMEM102","transmembrane protein 102",TRUE
+"220097_s_at",0.880203017022901,0.535645626158656,-0.629210331836106,-5.74867054990331,-0.253981327764593,"TMEM104","transmembrane protein 104",TRUE
+"1561243_at",0.987492202135276,0.94110814990369,0.0747198284272224,-5.93696454741112,0.0294999235580038,"TMEM105","transmembrane protein 105",TRUE
+"1552303_a_at",0.760244814241272,0.258551998710559,1.15960968450716,-5.30513201403368,0.863728274732225,"TMEM106A","transmembrane protein 106A",TRUE
+"234589_at",0.77364996239449,0.285037125605388,1.09556093210456,-5.37140458368474,0.871009609106546,"TMEM106A","transmembrane protein 106A",TRUE
+"234580_at",0.788656989718963,0.314856968844728,-1.02840291717205,-5.43728374304978,-0.549776885070834,"TMEM106A","transmembrane protein 106A",TRUE
+"1552302_at",0.79943091106207,0.334286615529151,0.987026034413126,-5.47599973199355,1.15986903204262,"TMEM106A","transmembrane protein 106A",TRUE
+"226529_at",0.71242055183987,0.186604018708711,1.36290633254987,-5.07331805774993,0.559017483314719,"TMEM106B","transmembrane protein 106B",TRUE
+"222787_s_at",0.748184017928985,0.240591315132745,1.20585972783854,-5.25522542171583,0.687182880864306,"TMEM106B","transmembrane protein 106B",TRUE
+"233666_at",0.760244814241272,0.258577113607057,1.1595467125011,-5.30519880055532,0.396038252424638,"TMEM106B","transmembrane protein 106B",TRUE
+"218930_s_at",0.761269771869579,0.26038419759914,1.15502754487,-5.3099834032174,0.417349534542888,"TMEM106B","transmembrane protein 106B",TRUE
+"201764_at",0.826140850652187,0.39408383193489,-0.869148527429509,-5.57829594770414,-0.415114081376053,"TMEM106C","transmembrane protein 106C",TRUE
+"239831_at",0.968035667633768,0.849335192571187,-0.192201310765591,-5.92170671472782,-0.0919611219835321,"TMEM106C","transmembrane protein 106C",TRUE
+"224495_at",0.667600335207197,0.133989574280524,1.55552783693539,-4.82523025160702,0.665171169834731,"TMEM107","transmembrane protein 107",TRUE
+"238590_x_at",0.683019114815084,0.151966855172362,1.4837325943969,-4.92079676591072,0.85932743161371,"TMEM107","transmembrane protein 107",TRUE
+"239824_s_at",0.702794018909517,0.174377753278948,1.40333131994705,-5.02347418794652,0.708479100101089,"TMEM107","transmembrane protein 107",TRUE
+"224496_s_at",0.838610044014507,0.423749397615957,0.814994999545888,-5.62124490457166,0.319307294140118,"TMEM107","transmembrane protein 107",TRUE
+"235490_at",0.955574463869973,0.796495565467696,-0.261009905813205,-5.90655610092566,-0.17106323263196,"TMEM107","transmembrane protein 107",TRUE
+"234818_at",0.756952614607938,0.252426302473426,1.17510646839945,-5.28859993740172,0.378591649591257,"TMEM108","transmembrane protein 108",TRUE
+"223524_s_at",0.897949253801113,0.586432045612285,-0.552061769164642,-5.79232053935204,-0.634928209214954,"TMEM108","transmembrane protein 108",TRUE
+"223523_at",0.907964244160782,0.618014132082631,0.50576845971227,-5.8158540719054,0.532135570613825,"TMEM108","transmembrane protein 108",TRUE
+"234813_at",0.907964244160782,0.618089952267736,-0.505658697726795,-5.81590748493675,-0.331977225248855,"TMEM108","transmembrane protein 108",TRUE
+"1562509_at",0.57982040775718,0.0625050111261238,1.9615092285125,-4.22157113198999,0.575011577618031,"TMEM108-AS1","TMEM108 antisense RNA 1",TRUE
+"201361_at",0.774360462422895,0.290499166962323,-1.08289590079732,-5.38411351397015,-0.412796143093022,"TMEM109","transmembrane protein 109",TRUE
+"203437_at",0.790496569256252,0.320246895455436,1.01675033356609,-5.44833255059534,0.303550717081446,"TMEM11","transmembrane protein 11",TRUE
+"227078_at",0.8920930097751,0.564057760476984,-0.58560647587657,-5.77401881296548,-0.219913701925483,"TMEM110","transmembrane protein 110",TRUE
+"213851_at",0.943988850936011,0.749577338067908,-0.323195938288883,-5.88893467243136,-0.101031114695685,"TMEM110","transmembrane protein 110",TRUE
+"226856_at",0.943400587031071,0.745966297492432,-0.328033159754329,-5.8874081594368,-0.23474996379348,"TMEM110-MUSTN1///MUSTN1///TMEM110","TMEM110-MUSTN1 readthrough///musculoskeletal, embryonic nuclear protein 1///transmembrane protein 110",TRUE
+"227127_at",0.861665593344139,0.483761379580844,-0.71222018745033,-5.69559180258763,-0.567192186668196,"TMEM110-MUSTN1///TMEM110","TMEM110-MUSTN1 readthrough///transmembrane protein 110",TRUE
+"231462_at",0.952082954955992,0.780908278280777,0.28154089228263,-5.90114986178125,0.102842261210353,"TMEM114","transmembrane protein 114",TRUE
+"216267_s_at",0.960857829396113,0.821971615279856,-0.227694700226339,-5.91446325404186,-0.199442175580884,"TMEM115","transmembrane protein 115",TRUE
+"227172_at",0.829485424009328,0.400838306131696,-0.856595540931641,-5.58848100731019,-0.431050831998498,"TMEM116","transmembrane protein 116",TRUE
+"234133_s_at",0.835487689403823,0.414725850762135,0.831205215795247,-5.60865931306491,0.550844064649976,"TMEM116","transmembrane protein 116",TRUE
+"233718_at",0.872238421308015,0.51520189149482,0.661358126797315,-5.72886110813219,0.407128769804412,"TMEM116","transmembrane protein 116",TRUE
+"223594_at",0.851733415458562,0.45666793865946,0.757608292664658,-5.6639248958197,0.945467716296631,"TMEM117","transmembrane protein 117",TRUE
+"227300_at",0.950265723886394,0.774290589833358,0.290294452526721,-5.89872139413318,0.14271951158974,"TMEM119","transmembrane protein 119",TRUE
+"223482_at",0.944963505981344,0.752333486558428,-0.319509192289296,-5.89008304612589,-0.0904412668275185,"TMEM120A","transmembrane protein 120A",TRUE
+"219154_at",0.714795139167042,0.190417929010511,-1.3507255778792,-5.08809898346639,-0.477587061359673,"TMEM120B","transmembrane protein 120B",TRUE
+"236667_at",0.740476003158683,0.229352811984774,-1.2361360144379,-5.2216387338424,-0.319063871755278,"TMEM120B","transmembrane protein 120B",TRUE
+"222914_s_at",0.536468823698363,0.0433296081472697,-2.1431774790836,-3.92036028640417,-1.52620467889742,"TMEM121","transmembrane protein 121",TRUE
+"219663_s_at",0.602351341567358,0.0771699795330439,-1.85352875313975,-4.39199567475789,-1.79511274455148,"TMEM121","transmembrane protein 121",TRUE
+"211967_at",0.726636642789909,0.206373196158806,1.3017528000589,-5.14639905487546,0.701440144583312,"TMEM123","transmembrane protein 123",TRUE
+"225822_at",0.784789297644843,0.309280509016011,1.04060721701234,-5.42559006493918,0.942802490699076,"TMEM125","transmembrane protein 125",TRUE
+"223334_at",0.892746695408886,0.565459125362724,0.58348584714903,-5.77520676111294,0.223325603842724,"TMEM126A","transmembrane protein 126A",TRUE
+"1554537_at",0.841391443291102,0.431994028993761,0.80037177580806,-5.6323988502316,0.255587385463368,"TMEM126B","transmembrane protein 126B",TRUE
+"221622_s_at",0.976371465776674,0.886119214640338,0.144875177972321,-5.92946576941334,0.0512979036927117,"TMEM126B","transmembrane protein 126B",TRUE
+"219460_s_at",0.87045636854107,0.509146292368179,-0.671015110285181,-5.72272562786971,-0.254983269969667,"TMEM127","transmembrane protein 127",TRUE
+"222887_s_at",0.900751557533293,0.596382375541019,-0.537349213189032,-5.80001701706339,-0.178319855297458,"TMEM127","transmembrane protein 127",TRUE
+"235659_at",0.944654135079729,0.751184573768848,0.32104547674258,-5.88960609868295,0.143352032605929,"TMEM127","transmembrane protein 127",TRUE
+"225462_at",0.434309499513877,0.0196874317641646,-2.51413397085545,-3.25604929900288,-0.980619318500288,"TMEM128","transmembrane protein 128",TRUE
+"225588_s_at",0.398419196938932,0.0138453859018559,-2.67294203227631,-2.9545373842871,-0.813677666569205,"TMEM129","transmembrane protein 129",TRUE
+"225587_at",0.462926905857638,0.0235123071713382,-2.43263729400545,-3.40708139243914,-0.905781239499762,"TMEM129","transmembrane protein 129",TRUE
+"238426_at",0.99886461451188,0.99495759725504,-0.00639144610815146,-5.93966358395568,-0.00367933714666346,"TMEM130","transmembrane protein 130",TRUE
+"212507_at",0.937113154905832,0.719802359580095,0.363329385140701,-5.87559086937961,0.111598908129922,"TMEM131","transmembrane protein 131",TRUE
+"235972_at",0.998047179825832,0.991290231904189,-0.0110401334393713,-5.93962411545476,-0.0038839343762529,"TMEM131","transmembrane protein 131",TRUE
+"218834_s_at",0.518874125067442,0.0372504629773383,-2.21619090967887,-3.79454275173273,-1.242197878183,"TMEM132A","transmembrane protein 132A",TRUE
+"229486_s_at",0.883875568487877,0.542232714843616,-0.618994303381599,-5.75476684418711,-0.263233083118661,"TMEM132A","transmembrane protein 132A",TRUE
+"222758_s_at",0.91671872326659,0.648034012211261,-0.462781423347429,-5.83590573592982,-0.347859144711808,"TMEM132A","transmembrane protein 132A",TRUE
+"232419_at",0.993474831312851,0.969236376074744,-0.0390041732355592,-5.93894252633948,-0.0291995220058148,"TMEM132A","transmembrane protein 132A",TRUE
+"236468_at",0.768014035136808,0.271173767867022,1.12851572043912,-5.33772102214146,0.360114374556205,"TMEM132B","transmembrane protein 132B",TRUE
+"236824_at",0.798737990058781,0.333267944338938,0.989153308668562,-5.47404444869321,0.819766286238281,"TMEM132B","transmembrane protein 132B",TRUE
+"1563488_at",0.843475287501313,0.438471300431484,0.789004122720184,-5.64093842892249,0.405976570452525,"TMEM132B","transmembrane protein 132B",TRUE
+"232313_at",0.672164152353115,0.138022722979017,1.53876132149233,-4.84786936258054,0.971327217081582,"TMEM132C","transmembrane protein 132C",TRUE
+"236377_at",0.637485146909712,0.108514191319497,1.67237431133447,-4.66217356535172,0.64975765994073,"TMEM132D","transmembrane protein 132D",TRUE
+"243708_at",0.73719941059815,0.223391309278283,-1.25265592202923,-5.20300996296083,-0.503478386467441,"TMEM132E","transmembrane protein 132E",TRUE
+"223595_at",0.398650588126476,0.0139683326732128,2.66899501146193,-2.96213942736041,2.83113016452902,"TMEM133","transmembrane protein 133",TRUE
+"218531_at",0.835223580564215,0.414259223477954,-0.832049496301918,-5.60799745946256,-0.438683528471525,"TMEM134","transmembrane protein 134",TRUE
+"1558712_at",0.945498722604777,0.753879128603039,-0.317443652069626,-5.89072073316643,-0.180815185260908,"TMEM134","transmembrane protein 134",TRUE
+"233018_at",0.976330538523238,0.885600498373975,-0.14553994788686,-5.92937183284938,-0.0850288725078308,"TMEM134","transmembrane protein 134",TRUE
+"222209_s_at",0.137844713664596,0.000902577183208512,-3.83023218327979,-0.566180477085148,-1.55711357816189,"TMEM135","transmembrane protein 135",TRUE
+"1554866_at",0.645771662212189,0.116953470493372,1.63133451163211,-4.72048168389307,0.606958654259768,"TMEM135","transmembrane protein 135",TRUE
+"208810_at",0.859947009633611,0.478335437859296,-0.721187834912619,-5.68948243380642,-0.307067756783082,"TMEM135///DNAJB6","transmembrane protein 135///DnaJ heat shock protein family (Hsp40) member B6",TRUE
+"208811_s_at",0.98539961718117,0.92833912629299,0.0909632826276895,-5.93565416857183,0.0404328537142167,"TMEM135///DNAJB6","transmembrane protein 135///DnaJ heat shock protein family (Hsp40) member B6",TRUE
+"238497_at",0.380013210154427,0.0117044763767729,-2.74756956432072,-2.80983092689296,-1.979044076219,"TMEM136","transmembrane protein 136",TRUE
+"1554076_s_at",0.988027606799625,0.942759949643099,-0.0726201753534488,-5.93711518725527,-0.025026551072628,"TMEM136","transmembrane protein 136",TRUE
+"230186_at",0.989524702314661,0.948712717332069,-0.065056134932974,-5.93762229335292,-0.0270793454085299,"TMEM136","transmembrane protein 136",TRUE
+"223113_at",0.485660910112228,0.0281970953603035,-2.34813075047823,-3.56081430140286,-0.809866408656537,"TMEM138","transmembrane protein 138",TRUE
+"229634_at",0.690015152288705,0.159581639993149,1.45540029117684,-4.95751010262123,2.16853041052352,"TMEM139","transmembrane protein 139",TRUE
+"227753_at",0.728385463227073,0.209779161675109,1.29168306522318,-5.1581609449202,1.78187108615119,"TMEM139","transmembrane protein 139",TRUE
+"218999_at",0.612420348961838,0.0843741344939402,1.80692580211904,-4.46343595469469,0.770849978428147,"TMEM140","transmembrane protein 140",TRUE
+"225568_at",0.728825906537591,0.210363084244531,-1.28996943311662,-5.1601548175112,-0.665947570057501,"TMEM141","transmembrane protein 141",TRUE
+"219589_s_at",0.769258076576208,0.275219255786998,-1.11877476479109,-5.34776947467389,-0.883660135029005,"TMEM143","transmembrane protein 143",TRUE
+"222905_s_at",0.819780516863333,0.377590780767809,0.900398945745185,-5.55234351267332,0.299419774188582,"TMEM143","transmembrane protein 143",TRUE
+"219750_at",0.826186401654508,0.394408619471135,-0.868541756172327,-5.57879143030147,-0.725962143234955,"TMEM144","transmembrane protein 144",TRUE
+"217613_at",0.877335480350728,0.527155467772878,-0.642478272333622,-5.74060976340817,-0.715703861663805,"TMEM144","transmembrane protein 144",TRUE
+"1558452_at",0.91671872326659,0.647627676396427,-0.46335722745605,-5.8356486562935,-0.18917629722834,"TMEM144","transmembrane protein 144",TRUE
+"228624_at",0.95952608973576,0.817181030497593,-0.233938142994253,-5.91306304803652,-0.179091557938708,"TMEM144","transmembrane protein 144",TRUE
+"1553479_at",0.653593944884398,0.122966251273231,-1.60358654694183,-4.75927311498771,-0.577229097355887,"TMEM145","transmembrane protein 145",TRUE
+"202475_at",0.73759219552868,0.224336556102996,-1.25001428974831,-5.20600308937794,-0.399861885558444,"TMEM147","transmembrane protein 147",TRUE
+"1558381_a_at",0.65284137151906,0.122233875084419,-1.6069048389232,-4.75466128999991,-0.444487192756172,"TMEM147-AS1","TMEM147 antisense RNA 1",TRUE
+"222280_at",0.957243533506016,0.806518163959545,-0.247869374500611,-5.9098029248921,-0.097004430377611,"TMEM147-AS1","TMEM147 antisense RNA 1",TRUE
+"218477_at",0.56861088242915,0.0583117115493095,1.99649696667548,-4.16493407473613,0.8479748142295,"TMEM14A","transmembrane protein 14A",TRUE
+"223133_at",0.683019114815084,0.151874270143185,1.48408410128565,-4.92033768930961,0.572180015401893,"TMEM14B","transmembrane protein 14B",TRUE
+"221452_s_at",0.699278997070299,0.170730230121471,1.41582797790126,-5.0078224287705,0.444831527764444,"TMEM14B","transmembrane protein 14B",TRUE
+"223105_s_at",0.713330901550199,0.188115053594407,1.35805716689547,-5.07921563122176,0.300728868878856,"TMEM14B///TMEM14C","transmembrane protein 14B///transmembrane protein 14C",TRUE
+"223106_at",0.638134354959023,0.109342600258771,1.66822895239281,-4.66811329413397,0.423998740112365,"TMEM14C","transmembrane protein 14C",TRUE
+"226239_at",0.112518135066489,0.000583723221955872,-4.00879395085315,-0.181720963815416,-2.20257496298297,"TMEM150A","transmembrane protein 150A",TRUE
+"1570225_at",0.641310340969603,0.111711745539909,1.65651841107536,-4.68483227538175,0.916701937641953,"TMEM150B","transmembrane protein 150B",TRUE
+"229623_at",0.683254141963065,0.152346616272002,-1.48229261968884,-4.9226764931641,-2.74331314757677,"TMEM150C","transmembrane protein 150C",TRUE
+"231923_at",0.728156825353177,0.208374437904473,-1.29582066855559,-5.15333742627136,-1.34507706360239,"TMEM150C","transmembrane protein 150C",TRUE
+"235614_at",0.683017520100356,0.151157900397341,-1.48680977062467,-4.9167749255192,-1.15847546613839,"TMEM151A","transmembrane protein 151A",TRUE
+"213676_at",0.499515085498997,0.0316095067787512,2.29437522863995,-3.65699746448913,0.748719881906747,"TMEM151B","transmembrane protein 151B",TRUE
+"1564066_at",0.803275622655718,0.341284313309772,0.97253203276931,-5.48921981467129,0.380446875947883,"TMEM151B","transmembrane protein 151B",TRUE
+"1564067_x_at",0.837368340567858,0.421271926158525,0.819423847623177,-5.6178294056171,0.388267529165739,"TMEM151B","transmembrane protein 151B",TRUE
+"213678_at",0.988953916818854,0.946664492812956,0.0676583034237717,-5.93745412408093,0.0366049229385945,"TMEM151B","transmembrane protein 151B",TRUE
+"238063_at",0.617775129514679,0.0883811893846329,1.78247664263621,-4.50038938458032,2.35372342955638,"TMEM154","transmembrane protein 154",TRUE
+"230137_at",0.523369751179323,0.0388764658226093,2.19566016129552,-3.83018394984791,1.06814658619115,"TMEM155","transmembrane protein 155",TRUE
+"220169_at",0.702794018909517,0.174358237592439,1.40339762399594,-5.02339144545626,1.59682743738091,"TMEM156","transmembrane protein 156",TRUE
+"241844_x_at",0.812302873476553,0.359676572051498,0.935378972541165,-5.52229028023255,0.765679197040265,"TMEM156","transmembrane protein 156",TRUE
+"213338_at",0.841967750949524,0.434883327734127,0.795288138335931,-5.63623197032071,1.32267276595676,"TMEM158","transmembrane protein 158 (gene/pseudogene)",TRUE
+"213272_s_at",0.677013732819214,0.144551925287496,-1.51245401590332,-4.88299813056631,-0.797617104565331,"TMEM159","transmembrane protein 159",TRUE
+"219219_at",0.831487912516861,0.406125016741364,-0.846864831366114,-5.59628119022299,-0.264747239461844,"TMEM160","transmembrane protein 160",TRUE
+"43977_at",0.978350741512096,0.895913395995018,0.132335463136607,-5.93115730060487,0.0366929230220148,"TMEM161A","transmembrane protein 161A",TRUE
+"218745_x_at",0.986285942607238,0.932961621504507,-0.0850803526898298,-5.93615840814143,-0.0296994707242195,"TMEM161A","transmembrane protein 161A",TRUE
+"244513_at",0.85829382652909,0.474035641146757,0.728336530783342,-5.68456019628749,0.443145350194124,"TMEM161B","transmembrane protein 161B",TRUE
+"227861_at",0.868313695469383,0.502634212252772,-0.681472111074956,-5.71598587306609,-0.220484603559367,"TMEM161B","transmembrane protein 161B",TRUE
+"236227_at",0.913123070637484,0.635203669751168,-0.481040988336113,-5.8276010261945,-0.205966834664206,"TMEM161B","transmembrane protein 161B",TRUE
+"238783_at",0.944801723928361,0.751822736245087,-0.320192051978871,-5.889871328477,-0.108890408514277,"TMEM161B","transmembrane protein 161B",TRUE
+"229815_at",0.71611852101483,0.191790505603792,-1.34638888614869,-5.09333461550904,-1.39204815628852,"TMEM161B-AS1","TMEM161B antisense RNA 1",TRUE
+"235406_x_at",0.727286289873957,0.207629520473157,1.29802358971373,-5.15076397176355,0.373779458687499,"TMEM161B-AS1","TMEM161B antisense RNA 1",TRUE
+"241035_s_at",0.746836086007095,0.238750409071408,1.21074481867625,-5.24985498518003,0.920515307837985,"TMEM161B-AS1","TMEM161B antisense RNA 1",TRUE
+"239840_at",0.893334037681196,0.567949022025799,0.579724631139703,-5.7773034854564,0.204559739896906,"TMEM161B-AS1","TMEM161B antisense RNA 1",TRUE
+"223503_at",0.792436690618566,0.323853730292065,1.00902902592153,-5.45559103712423,0.624602382600742,"TMEM163","transmembrane protein 163",TRUE
+"1552626_a_at",0.803111243433434,0.340780582626433,0.973568540653729,-5.48828032720415,0.781490128878568,"TMEM163","transmembrane protein 163",TRUE
+"222515_x_at",0.746259710622309,0.237975705789416,-1.21280908967916,-5.2475799658745,-0.881196468141482,"TMEM165","transmembrane protein 165",TRUE
+"226827_at",0.782672765138354,0.305025286165926,-1.05002485854866,-5.41648159061087,-0.664488008204859,"TMEM165","transmembrane protein 165",TRUE
+"218095_s_at",0.784448016670989,0.307459278603042,-1.04462666089711,-5.42171160135415,-0.399323164539993,"TMEM165","transmembrane protein 165",TRUE
+"226825_s_at",0.819018525257656,0.37524701591482,-0.904911970754963,-5.54852550075775,-0.356496369386038,"TMEM165","transmembrane protein 165",TRUE
+"230657_at",0.854184492233394,0.464000386939716,-0.74517074203829,-5.67278697257326,-0.4723229816014,"TMEM165","transmembrane protein 165",TRUE
+"230512_x_at",0.883416982510262,0.541505930532216,-0.620118214449193,-5.75410086955415,-0.394641863568741,"TMEM165","transmembrane protein 165",TRUE
+"224702_at",0.960819760730297,0.821920457779913,-0.227761323134986,-5.91444851154915,-0.0855382618888729,"TMEM167A","transmembrane protein 167A",TRUE
+"226276_at",0.993819570187391,0.970701543476456,-0.0371456208013155,-5.93901145477858,-0.015645753432862,"TMEM167A","transmembrane protein 167A",TRUE
+"222495_at",0.67966398171993,0.146994058324768,-1.50286428607529,-4.89568324743297,-0.701464866812993,"TMEM167B","transmembrane protein 167B",TRUE
+"234726_s_at",0.947778780715578,0.761717874690784,-0.306989685476896,-5.89388530962662,-0.122591361409858,"TMEM168","transmembrane protein 168",TRUE
+"218962_s_at",0.977369242833284,0.891636404531638,-0.137808599659369,-5.93043779355841,-0.0535334924859576,"TMEM168","transmembrane protein 168",TRUE
+"228981_at",0.969603512618622,0.854858600599987,-0.1850689121283,-5.92301507949351,-0.100049713779115,"TMEM169","transmembrane protein 169",TRUE
+"1557137_at",0.201150961341713,0.00225156631625291,3.45240133954985,-1.37143217473709,1.44341846516139,"TMEM17","transmembrane protein 17",TRUE
+"230414_s_at",0.525827459853233,0.0394502833162865,2.18860064229384,-3.84239224933637,0.96776701547385,"TMEM170A","transmembrane protein 170A",TRUE
+"227586_at",0.955752634534966,0.798269772449451,-0.258680404363901,-5.90714383584409,-0.0989037859835982,"TMEM170A","transmembrane protein 170A",TRUE
+"228505_s_at",0.971216837324271,0.86266799333199,-0.175001259659686,-5.92477795674563,-0.0652659158728106,"TMEM170A","transmembrane protein 170A",TRUE
+"235798_at",0.18860161541457,0.00186963101151709,-3.52972159883155,-1.2079111608472,-2.89380919701112,"TMEM170B","transmembrane protein 170B",TRUE
+"240770_at",0.509266881234697,0.0338672954763486,2.26166198202936,-3.7148932811382,1.8306053297774,"TMEM171","transmembrane protein 171",TRUE
+"1553559_at",0.622434989367596,0.0930741405714874,1.75502776873448,-4.54143784124903,0.848285289814874,"TMEM171","transmembrane protein 171",TRUE
+"224929_at",0.698391916012681,0.16936058485818,1.42057566205891,-5.00184616905778,1.1322281976839,"TMEM173","transmembrane protein 173",TRUE
+"224916_at",0.820293495506061,0.379106902519897,0.897489408366637,-5.55479562046189,0.762953188436534,"TMEM173","transmembrane protein 173",TRUE
+"231623_at",0.755049574909504,0.248864860640514,1.18424529399663,-5.27876064877401,0.417687234442909,"TMEM174","transmembrane protein 174",TRUE
+"243569_at",0.852006864319744,0.457338678692951,0.756465614477536,-5.66474487564607,0.216747831284234,"TMEM174","transmembrane protein 174",TRUE
+"240114_s_at",0.937113154905832,0.719881795278409,0.363221531337866,-5.87562879494152,0.119255170979706,"TMEM174","transmembrane protein 174",TRUE
+"223462_at",0.616498361180066,0.0874317017391903,-1.78818217342343,-4.49179857622408,-0.734658174316601,"TMEM175","transmembrane protein 175",TRUE
+"218345_at",0.969882914559333,0.85655677845004,-0.18287803896766,-5.92340707373995,-0.200424891541851,"TMEM176A","transmembrane protein 176A",TRUE
+"236348_at",0.704148059811236,0.176038127662479,1.39771178965672,-5.03047521575063,0.713322910231265,"TMEM176B","transmembrane protein 176B",TRUE
+"220532_s_at",0.946215823740655,0.756176574348864,0.314376027296065,-5.89166023136151,0.398435612433804,"TMEM176B","transmembrane protein 176B",TRUE
+"218897_at",0.707862843310802,0.179519454693143,-1.38606494479373,-5.04491133508062,-0.447381712263184,"TMEM177","transmembrane protein 177",TRUE
+"237506_at",0.908008907845691,0.618326248868967,0.505316660528766,-5.81607385657814,0.223743640362233,"TMEM177","transmembrane protein 177",TRUE
+"229302_at",0.865561991774564,0.495480591845436,0.6930479480034,-5.70840884673348,0.953627356500109,"TMEM178A","transmembrane protein 178A",TRUE
+"238936_at",0.953931868692178,0.787441860023415,0.272920571481098,-5.90346925011619,0.159063162896511,"TMEM178B","transmembrane protein 178B",TRUE
+"231143_at",0.985361089461736,0.927544447761058,0.0919749749008916,-5.93556406062005,0.0399566317689919,"TMEM178B","transmembrane protein 178B",TRUE
+"227318_at",0.992342196993659,0.964183240866008,-0.0454151548527849,-5.93867894529763,-0.0368292639380892,"TMEM178B","transmembrane protein 178B",TRUE
+"231216_at",0.820536502908875,0.380111191407065,0.895566323403952,-5.5564123337047,0.359062680412067,"TMEM179","transmembrane protein 179",TRUE
+"225487_at",0.906476756086155,0.6138348881352,0.51182838720208,-5.81288760948476,0.171553622666819,"TMEM18","transmembrane protein 18",TRUE
+"225489_at",0.97689149311934,0.88935654307529,0.140727820787355,-5.93004212789715,0.0581175346243246,"TMEM18","transmembrane protein 18",TRUE
+"225127_at",0.767011398042819,0.268306433775502,1.13548445605068,-5.33048508592371,0.489857133915828,"TMEM181","transmembrane protein 181",TRUE
+"233348_at",0.902810270244072,0.602450715119092,0.528435324991243,-5.80458172147112,0.364127452470553,"TMEM181","transmembrane protein 181",TRUE
+"238867_at",0.805859691692007,0.346120118836583,-0.962634354927876,-5.49814501216699,-0.356111608591627,"TMEM182","transmembrane protein 182",TRUE
+"1553301_a_at",0.846015118644589,0.444014092978161,0.779358164813147,-5.64809441110771,0.388171719568205,"TMEM182","transmembrane protein 182",TRUE
+"238578_at",0.940044918888428,0.731081344409856,0.348058520499916,-5.8808499870193,0.227040327635621,"TMEM182","transmembrane protein 182",TRUE
+"1555090_x_at",0.993474831312851,0.969217706861845,0.0390278558681795,-5.93894162631097,0.013040123451729,"TMEM182","transmembrane protein 182",TRUE
+"212165_at",0.245363000968222,0.0033115913471923,-3.29085867676883,-1.71024023792948,-1.05350852213346,"TMEM183B///TMEM183A","transmembrane protein 183B///transmembrane protein 183A",TRUE
+"212164_at",0.402463840838386,0.0148079858687213,-2.64288297954272,-3.01229764694677,-0.948794393780208,"TMEM183B///TMEM183A","transmembrane protein 183B///transmembrane protein 183A",TRUE
+"1558281_a_at",0.945432830098469,0.753347883969956,-0.318153428843966,-5.89050206813272,-0.341111903814933,"TMEM184A","transmembrane protein 184A",TRUE
+"235817_at",0.989768753740502,0.950673286808611,0.0625657592139206,-5.93777706451948,0.0342580560743979,"TMEM184A","transmembrane protein 184A",TRUE
+"202027_at",0.635916735157933,0.107129858543326,1.6793616188496,-4.65213641635153,0.527336079487375,"TMEM184B","transmembrane protein 184B",TRUE
+"219074_at",0.603702127972549,0.0775470716191569,-1.85099752160108,-4.39590931606197,-0.51842044040311,"TMEM184C","transmembrane protein 184C",TRUE
+"1554105_at",0.694505490882266,0.163856423580781,-1.43997144276733,-4.97726109668736,-0.378969407418834,"TMEM185A","transmembrane protein 185A",TRUE
+"227880_s_at",0.713005775571409,0.187603649173387,-1.3596948983676,-5.07722577809352,-0.465621497178923,"TMEM185A","transmembrane protein 185A",TRUE
+"231326_s_at",0.7768734672127,0.295053331265126,1.07246630848005,-5.39448021525449,0.697859496873045,"TMEM185A","transmembrane protein 185A",TRUE
+"227604_at",0.812302873476553,0.356910129038691,-0.940883879499929,-5.51746478880964,-0.477807365220339,"TMEM185B","transmembrane protein 185B",TRUE
+"219253_at",0.981215182293986,0.911352787585581,-0.112611284717889,-5.93350877329671,-0.033760437103096,"TMEM185B","transmembrane protein 185B",TRUE
+"204676_at",0.666643938027574,0.133468837572807,-1.55772290048113,-4.8222520172762,-0.447951806747012,"TMEM186","transmembrane protein 186",TRUE
+"204340_at",0.63418824799514,0.105005435066087,-1.69023461934698,-4.63645460100489,-0.789446181073425,"TMEM187","transmembrane protein 187",TRUE
+"223186_at",0.933005936987066,0.704186977516384,0.384618551854968,-5.86788726375364,0.156050117700616,"TMEM189-UBE2V1///TMEM189///UBE2V1","TMEM189-UBE2V1 readthrough///transmembrane protein 189///ubiquitin conjugating enzyme E2 V1",TRUE
+"201003_x_at",0.635916735157933,0.107170240983898,-1.67915671288714,-4.65243121149603,-0.688384441211264,"TMEM189-UBE2V1///TMEM189///UBE2V2///UBE2V1","TMEM189-UBE2V1 readthrough///transmembrane protein 189///ubiquitin conjugating enzyme E2 V2///ubiquitin conjugating enzyme E2 V1",TRUE
+"201002_s_at",0.900692252557887,0.596008055337491,-0.5379004962881,-5.79973227233111,-0.199478284050565,"TMEM189-UBE2V1///TMEM189///UBE2V2///UBE2V1","TMEM189-UBE2V1 readthrough///transmembrane protein 189///ubiquitin conjugating enzyme E2 V2///ubiquitin conjugating enzyme E2 V1",TRUE
+"201001_s_at",0.984161165881616,0.922647085850193,-0.0982119391373618,-5.93498656368256,-0.0399617872650939,"TMEM189-UBE2V1///TMEM189///UBE2V2///UBE2V1","TMEM189-UBE2V1 readthrough///transmembrane protein 189///ubiquitin conjugating enzyme E2 V2///ubiquitin conjugating enzyme E2 V1",TRUE
+"229126_at",0.663789119801086,0.131730707709577,1.56510130164097,-4.81221686637426,0.622613576788313,"TMEM19","transmembrane protein 19",TRUE
+"230676_s_at",0.72050514215489,0.196530325170886,1.33159824286086,-5.11108491702532,0.403916603798537,"TMEM19","transmembrane protein 19",TRUE
+"226860_at",0.859486825765374,0.477099674438339,0.723238506558061,-5.68807516352971,0.227802630510363,"TMEM19","transmembrane protein 19",TRUE
+"219941_at",0.921312278448293,0.664854112669519,0.439082305036117,-5.84621475445447,0.155530636249768,"TMEM19","transmembrane protein 19",TRUE
+"1552594_at",0.606900628956089,0.0803693224093773,1.83238578005371,-4.42456850414867,1.2166726918457,"TMEM190","transmembrane protein 190",TRUE
+"223628_at",0.966925852992772,0.845744187164753,-0.196843845014111,-5.92082860490098,-0.184623703169589,"TMEM191A","transmembrane protein 191A (pseudogene)",TRUE
+"226589_at",0.73223722457785,0.216424184388852,-1.27239539339292,-5.18047270334742,-0.514257395632688,"TMEM192","transmembrane protein 192",TRUE
+"1555790_a_at",0.46584896273628,0.0242220091758227,-2.41888556294506,-3.43230259244849,-1.10289057084952,"TMEM192///ZNF320","transmembrane protein 192///zinc finger protein 320",TRUE
+"236705_at",0.70772084164277,0.179256349723341,-1.38693886265758,-5.04383159533642,-1.22776764594558,"TMEM196","transmembrane protein 196",TRUE
+"1552293_at",0.915569510513076,0.643876400189687,0.468680577534512,-5.83325711173263,0.185429081967445,"TMEM196","transmembrane protein 196",TRUE
+"242782_x_at",0.974292018919448,0.874543885734984,-0.159726233462125,-5.92726493163194,-0.120500534926352,"TMEM198","transmembrane protein 198",TRUE
+"227890_at",0.980264692225439,0.907944734236574,-0.116960937476407,-5.93302272060239,-0.0472265551759978,"TMEM198","transmembrane protein 198",TRUE
+"227106_at",0.784708646973769,0.308533642744897,1.0422535169846,-5.42400313508185,0.337458315429302,"TMEM198B","transmembrane protein 198B (pseudogene)",TRUE
+"1557124_at",0.886742569466783,0.549772283855235,0.607381881954462,-5.76157959557256,0.412596095515108,"TMEM198B","transmembrane protein 198B (pseudogene)",TRUE
+"218113_at",0.869082033398093,0.505951310556764,-0.676136103417052,-5.71943750000652,-0.396480803157768,"TMEM2","transmembrane protein 2",TRUE
+"234994_at",0.0732399021738498,0.000235760819069,4.37886672947529,0.617666616472983,4.2988960825043,"TMEM200A","transmembrane protein 200A",TRUE
+"227386_s_at",0.640067422642767,0.110614343814094,1.66191647856479,-4.67713666951358,2.05052905162369,"TMEM200B","transmembrane protein 200B",TRUE
+"229523_at",0.957571530817866,0.809494217254819,-0.243976179749137,-5.91073286657743,-0.143500328438853,"TMEM200C","transmembrane protein 200C",TRUE
+"238128_at",0.997128956162635,0.985404842829255,0.0185009137891417,-5.93951676829974,0.0118064260634392,"TMEM200C","transmembrane protein 200C",TRUE
+"228671_at",0.618124814816155,0.0890696739855969,1.77837242576145,-4.50655670366703,0.820703962591558,"TMEM201","transmembrane protein 201",TRUE
+"227617_at",0.89967769475675,0.591237607361022,-0.544941080737515,-5.79607076104566,-0.448962665910152,"TMEM201","transmembrane protein 201",TRUE
+"225052_at",0.527329900969895,0.0398619932456987,-2.18359263657443,-3.85103811186267,-0.716412607211273,"TMEM203","transmembrane protein 203",TRUE
+"228947_x_at",0.816941414563225,0.369122939079001,0.916792818851822,-5.53839008190191,0.427576573008964,"TMEM204","transmembrane protein 204",TRUE
+"222865_x_at",0.969946179106301,0.857855636755179,-0.18120295924923,-5.92370364259576,-0.10126611598513,"TMEM204","transmembrane protein 204",TRUE
+"219315_s_at",0.984244246588495,0.923125526494091,0.0976024561425224,-5.93504466565114,0.0421180386351176,"TMEM204","transmembrane protein 204",TRUE
+"225003_at",0.920029531612896,0.659543804143895,-0.446536199503348,-5.84302962264355,-0.260162242017202,"TMEM205","transmembrane protein 205",TRUE
+"218814_s_at",0.827985973549523,0.39754578409551,0.862697421684544,-5.58354737172378,0.237328509667358,"TMEM206","transmembrane protein 206",TRUE
+"222752_s_at",0.939166148226364,0.727747325911106,0.352563580006343,-5.87932169136731,0.130572233106788,"TMEM206","transmembrane protein 206",TRUE
+"237639_at",0.980326403741224,0.90825096716251,-0.116570003253921,-5.93306715794274,-0.0778070967943254,"TMEM207","transmembrane protein 207",TRUE
+"221597_s_at",0.627092759817312,0.0988007729390028,-1.72309654522367,-4.58859686464866,-0.550976691384571,"TMEM208","transmembrane protein 208",TRUE
+"222267_at",0.79814964343286,0.332435036302239,-0.99089599189571,-5.47243980956042,-0.433885127418415,"TMEM209","transmembrane protein 209",TRUE
+"235158_at",0.837368340567858,0.421045944302544,-0.819828635079511,-5.6175163709175,-0.280453037042113,"TMEM209","transmembrane protein 209",TRUE
+"217016_x_at",0.99164669139131,0.960570517266478,-0.0499998467018512,-5.93846590374532,-0.0169308214218908,"TMEM212","transmembrane protein 212",TRUE
+"239593_at",0.404317059691879,0.015048655079524,2.6356554634263,-3.02613927743539,1.24693440141366,"TMEM213","transmembrane protein 213",TRUE
+"240183_at",0.822469863206885,0.387474691110799,0.881566865845424,-5.56808469614809,0.552026829587378,"TMEM213","transmembrane protein 213",TRUE
+"217899_at",0.615821255316333,0.0868030944320366,1.79198896950067,-4.4860555689541,0.562102525496444,"TMEM214","transmembrane protein 214",TRUE
+"223305_at",0.697713925841949,0.168561957724662,-1.42335820887786,-4.998335940657,-0.459564573755245,"TMEM216","transmembrane protein 216",TRUE
+"237016_at",0.65284137151906,0.122062817366849,1.60768226779177,-4.75357973546634,1.29246110659366,"TMEM217","transmembrane protein 217",TRUE
+"235876_at",0.67397614409571,0.140564171412352,1.52840229567764,-4.86175952241954,1.17455070072554,"TMEM218","transmembrane protein 218",TRUE
+"235654_at",0.763494494236835,0.263249580713491,1.14790907440705,-5.31748668133153,0.75632505472472,"TMEM218","transmembrane protein 218",TRUE
+"226073_at",0.901039361385093,0.597314524982217,0.535977113960153,-5.80072449083743,0.276623182523982,"TMEM218","transmembrane protein 218",TRUE
+"224981_at",0.780323446630392,0.301835870140994,-1.05714491439837,-5.40954634460601,-0.373305417981985,"TMEM219","transmembrane protein 219",TRUE
+"228513_at",0.99177641642161,0.962100216745967,-0.0480584681779241,-5.9385586143826,-0.0153129807165433,"TMEM219","transmembrane protein 219",TRUE
+"229693_at",0.49018628652281,0.0293157801382073,2.32987913081666,-3.59361501825592,2.25336035300239,"TMEM220","transmembrane protein 220",TRUE
+"1559687_at",0.878907265409251,0.532472322988862,0.634155966717071,-5.74568479757289,0.322732418663764,"TMEM221","transmembrane protein 221",TRUE
+"239128_at",0.898197048519062,0.587249197867598,0.550848917582461,-5.79296264768252,0.364237250708757,"TMEM221","transmembrane protein 221",TRUE
+"221512_at",0.797508506396963,0.331029194568357,-0.993844268661804,-5.46971923028466,-0.252865952978905,"TMEM222","transmembrane protein 222",TRUE
+"52078_at",0.91269009113888,0.633675636245443,-0.483226591524693,-5.82658591852756,-0.115978470973287,"TMEM222","transmembrane protein 222",TRUE
+"213818_x_at",0.85334340854827,0.461515600960053,0.749372276261787,-5.66980880793789,0.523556660456925,"TMEM223","transmembrane protein 223",TRUE
+"220934_s_at",0.904092974845832,0.606218708972087,-0.522922229175226,-5.80736771596961,-0.190470698707045,"TMEM223","transmembrane protein 223",TRUE
+"238981_at",0.93667390723462,0.717285776351281,0.366748557429094,-5.87438279430605,0.248120019309486,"TMEM223","transmembrane protein 223",TRUE
+"244460_at",0.884221189678062,0.543132906525113,0.617603344919185,-5.75558944593874,0.23380682197039,"TMEM225","transmembrane protein 225",TRUE
+"227544_at",0.587626678796111,0.0666481440644245,-1.9289209704013,-4.2737093679369,-2.90102310154481,"TMEM229B","transmembrane protein 229B",TRUE
+"238820_at",0.901788521024914,0.599670503252818,0.53251380455075,-5.8025023963059,0.366719763810688,"TMEM229B","transmembrane protein 229B",TRUE
+"1558177_at",0.951568785371415,0.777933364416512,0.285473144497092,-5.90006807734094,0.18979043088428,"TMEM229B","transmembrane protein 229B",TRUE
+"220477_s_at",0.883157099275963,0.540975114985849,0.620939584942941,-5.75361342944683,0.271677182770947,"TMEM230","transmembrane protein 230",TRUE
+"224584_at",0.884221189678062,0.543155938620647,0.61756777229287,-5.755610459917,0.251105796621111,"TMEM230","transmembrane protein 230",TRUE
+"219182_at",0.847797601020174,0.447189545026521,0.773865129289898,-5.65213240066421,0.341908849391251,"TMEM231","transmembrane protein 231",TRUE
+"64900_at",0.982243328340126,0.914467437553471,0.108638046272625,-5.93393668647901,0.077235351021649,"TMEM231","transmembrane protein 231",TRUE
+"239776_at",0.631294544151106,0.102349778426756,-1.70409208084901,-4.6163578942149,-1.62236572395851,"TMEM232","transmembrane protein 232",TRUE
+"1562732_at",0.904706869570492,0.609094830706718,-0.518725089382852,-5.80946962351428,-0.414641306391908,"TMEM232","transmembrane protein 232",TRUE
+"1568698_at",0.929972194057784,0.690814056221386,-0.402995074890787,-5.86089006179069,-0.304336680800406,"TMEM232","transmembrane protein 232",TRUE
+"223656_s_at",0.758920166935337,0.256308383555625,1.16525361571543,-5.29913328786679,0.291928296717748,"TMEM234","transmembrane protein 234",TRUE
+"234930_at",0.904381089098038,0.607851795888,-0.520537894714369,-5.80856380363753,-0.337009103234875,"TMEM234","transmembrane protein 234",TRUE
+"223676_at",0.945742372463206,0.755019822874193,0.315920173117061,-5.8911884469133,0.256888976803105,"TMEM234","transmembrane protein 234",TRUE
+"234006_s_at",0.98539961718117,0.927795902755246,-0.0916548410651664,-5.93559268154089,-0.0375775195533956,"TMEM234","transmembrane protein 234",TRUE
+"1564040_a_at",0.868397087637799,0.504052499896269,0.67918817833488,-5.71746642451295,0.546709394098883,"TMEM235","transmembrane protein 235",TRUE
+"1553956_at",0.921388946695144,0.665094722866376,0.438745169936015,-5.84635757221622,0.186453000471396,"TMEM237","transmembrane protein 237",TRUE
+"228255_at",0.970135831114343,0.858261914055798,-0.180679110658543,-5.92379583035292,-0.0938401013380439,"TMEM237","transmembrane protein 237",TRUE
+"229938_at",0.650490742096872,0.120610124775177,-1.61432146538726,-4.74432681560589,-1.1746493240666,"TMEM238","transmembrane protein 238",TRUE
+"1554042_s_at",0.9116561917482,0.630749981473677,-0.487417946507102,-5.82462665034925,-0.338893005034757,"TMEM239","transmembrane protein 239",TRUE
+"1554041_at",0.925091998149497,0.675538556019198,0.424160661693001,-5.8524327365541,0.280901273268703,"TMEM239","transmembrane protein 239",TRUE
+"244495_x_at",0.642791771775834,0.113180729526949,-1.6493620815675,-4.69500503282836,-0.481348278211337,"TMEM241","transmembrane protein 241",TRUE
+"224493_x_at",0.943824539742785,0.748372878765459,-0.324808509163667,-5.88842827736058,-0.110870127691081,"TMEM241","transmembrane protein 241",TRUE
+"222638_s_at",0.608022149123589,0.0811252231889636,1.82749734018038,-4.43206156924321,0.558686846562798,"TMEM242","transmembrane protein 242",TRUE
+"230457_at",0.673190784310977,0.138750344145124,1.53577958820483,-4.85187512523007,1.23886279037661,"TMEM242","transmembrane protein 242",TRUE
+"218453_s_at",0.784925710185113,0.309964882541027,1.03910113189993,-5.42703985840923,0.369027343227126,"TMEM242","transmembrane protein 242",TRUE
+"229769_at",0.960693014177181,0.82145626182895,0.228365898246589,-5.91431453340985,0.145106594451954,"TMEM242","transmembrane protein 242",TRUE
+"204215_at",0.88330056907699,0.54124800326713,0.620517270833635,-5.75386412826053,0.195529829926997,"TMEM243","transmembrane protein 243",TRUE
+"227831_at",0.480603497646452,0.0271378040793533,2.36603841403935,-3.52849059558482,1.55697836818536,"TMEM245","transmembrane protein 245",TRUE
+"223005_s_at",0.682504456039784,0.150063601122,1.49099377614774,-4.91129571175475,0.552848217443346,"TMEM245","transmembrane protein 245",TRUE
+"223007_s_at",0.864894115958506,0.493082656675894,0.696949517080103,-5.70582759864637,0.271160617457113,"TMEM245","transmembrane protein 245",TRUE
+"223006_s_at",0.962351204352784,0.828483141731675,0.219223162886858,-5.91630288489385,0.0829086857981611,"TMEM245","transmembrane protein 245",TRUE
+"223008_s_at",0.996437521591612,0.982495597421195,0.0221892717478559,-5.9394436713502,0.00818196354935097,"TMEM245","transmembrane protein 245",TRUE
+"224458_at",0.090083930472689,0.000350944255888116,4.21659680085972,0.267055296241706,3.0312037146505,"TMEM246","transmembrane protein 246",TRUE
+"213386_at",0.380084968057051,0.0118375614449333,2.74256794787799,-2.81958582961057,1.09467653910739,"TMEM246","transmembrane protein 246",TRUE
+"224688_at",0.995025131654789,0.976767631979749,-0.0294521907778386,-5.93926099565876,-0.0116734061198773,"TMEM248","transmembrane protein 248",TRUE
+"218008_at",0.995375928428862,0.978584969833396,0.0271476943479312,-5.93932452290837,0.0066785880366016,"TMEM248","transmembrane protein 248",TRUE
+"238514_at",0.819018525257656,0.374926325963513,0.905530919060274,-5.54800049631535,0.653820667511121,"TMEM25","transmembrane protein 25",TRUE
+"226647_at",0.978999293602992,0.898415682547022,0.129135292192083,-5.93156451568871,0.078939572965611,"TMEM25","transmembrane protein 25",TRUE
+"213246_at",0.380084968057051,0.0117661120707522,-2.74524650553748,-2.81436269325809,-1.25507891736541,"TMEM251","transmembrane protein 251",TRUE
+"1553809_a_at",0.980264692225439,0.90780807074494,0.117135406892844,-5.93300284078015,0.0598696555684679,"TMEM252","transmembrane protein 252",TRUE
+"1558594_at",0.713724591137462,0.188927507615453,-1.35546255193612,-5.0823640027297,-0.840758997595598,"TMEM253","transmembrane protein 253",TRUE
+"218174_s_at",0.708702460344186,0.180716320606399,-1.38210227909222,-5.04980019314188,-0.770505942640218,"TMEM254","transmembrane protein 254",TRUE
+"222545_s_at",0.859465912277024,0.476789393650029,-0.723753885783704,-5.68772088798162,-0.59645309396335,"TMEM254","transmembrane protein 254",TRUE
+"232294_at",0.904832003218088,0.610002764921137,-0.517402096747769,-5.81012875095657,-0.441159792192509,"TMEM254-AS1","TMEM254 antisense RNA 1",TRUE
+"219895_at",0.0595361125571683,0.000129595979909259,4.62309603607218,1.14424998807405,4.74648473697128,"TMEM255A","transmembrane protein 255A",TRUE
+"238226_at",0.8376750578867,0.42229664612246,0.81759003569173,-5.61924573428683,0.784089931073654,"TMEM255B","transmembrane protein 255B",TRUE
+"227063_at",0.737573517874932,0.223949848564092,1.25109397124515,-5.20478040149158,0.399721057282864,"TMEM256","transmembrane protein 256",TRUE
+"56197_at",0.309481421123565,0.0065134711063697,3.00314037505422,-2.3015918865408,1.07448898881652,"TMEM256-PLSCR3///PLSCR3","TMEM256-PLSCR3 readthrough (NMD candidate)///phospholipid scramblase 3",TRUE
+"218828_at",0.362885168249175,0.0105000374327394,2.79545874144764,-2.71603381582235,1.57637598674725,"TMEM256-PLSCR3///PLSCR3","TMEM256-PLSCR3 readthrough (NMD candidate)///phospholipid scramblase 3",TRUE
+"206711_at",0.76912869907427,0.275077803470738,1.11911359115502,-5.34742124643389,0.519241214430047,"TMEM257","transmembrane protein 257",TRUE
+"218213_s_at",0.918794763792623,0.65521367791997,-0.452633305815062,-5.8403851601465,-0.135439438085054,"TMEM258","transmembrane protein 258",TRUE
+"225247_at",0.737123149977386,0.223165971679482,-1.25328692210196,-5.20229419998752,-0.463852734940527,"TMEM259","transmembrane protein 259",TRUE
+"212575_at",0.922718347740513,0.669555148207721,0.432504666492806,-5.84898173602481,0.413912055036269,"TMEM259","transmembrane protein 259",TRUE
+"213986_s_at",0.925993992481316,0.679178004581512,0.419100335649242,-5.85449345362018,0.20154511579231,"TMEM259","transmembrane protein 259",TRUE
+"212574_x_at",0.94478605487516,0.751595234692182,0.320496265540026,-5.88977686429189,0.127370235020321,"TMEM259","transmembrane protein 259",TRUE
+"213985_s_at",0.958794064221941,0.813611511726405,0.238596377587941,-5.91199381364928,0.128930102625982,"TMEM259","transmembrane protein 259",TRUE
+"230089_s_at",0.996261754016157,0.981970431682341,-0.0228551119632597,-5.93942906353362,-0.0192171481276038,"TMEM259","transmembrane protein 259",TRUE
+"1555025_at",0.748067267263424,0.240021472674178,1.20736886264877,-5.25356836137167,1.03413842079979,"TMEM26","transmembrane protein 26",TRUE
+"1560517_s_at",0.8920930097751,0.563863963594952,0.585899954081906,-5.77385408192454,0.526892698499703,"TMEM26-AS1","TMEM26 antisense RNA 1",TRUE
+"1560516_at",0.948429371744093,0.765529325640398,-0.301919290904297,-5.89538238189611,-0.348353126399458,"TMEM26-AS1","TMEM26 antisense RNA 1",TRUE
+"225675_at",0.947778780715578,0.761870248041268,-0.30678682555399,-5.89394568005589,-0.0960041320324496,"TMEM260","transmembrane protein 260",TRUE
+"219757_s_at",0.968888543030183,0.853029497866373,0.187429733347853,-5.92258746990875,0.0788638561567172,"TMEM260","transmembrane protein 260",TRUE
+"224860_at",0.839519981963042,0.42805582910679,-0.807334960251922,-5.62711128749047,-0.367791938918647,"TMEM261","transmembrane protein 261",TRUE
+"224879_at",0.999488289991365,0.998401719851588,0.00202587071383079,-5.93968148176811,0.0012607737992365,"TMEM261","transmembrane protein 261",TRUE
+"213740_s_at",0.972819824894874,0.868391085623985,0.167635004878638,-5.92600554026023,0.122504742738943,"TMEM262","transmembrane protein 262",TRUE
+"224759_s_at",0.74413941468137,0.23489898780038,-1.22105774558143,-5.23845568502322,-0.441097607657257,"TMEM263","transmembrane protein 263",TRUE
+"213667_at",0.821745015752602,0.384584598549108,0.887040576858964,-5.56354115155685,0.656240864728327,"TMEM265///SRCAP","transmembrane protein 265///Snf2-related CREBBP activator protein",TRUE
+"38766_at",0.978255630670068,0.894844989608524,0.133702275929818,-5.93098034379253,0.0606360076086148,"TMEM265///SRCAP","transmembrane protein 265///Snf2-related CREBBP activator protein",TRUE
+"1552400_a_at",0.929786324276714,0.69010873484378,0.403968173836516,-5.86051057212555,0.168710204711977,"TMEM266","transmembrane protein 266",TRUE
+"1557828_a_at",0.710524994175401,0.183446553372035,1.37314015266002,-5.06081416611951,0.78268953810759,"TMEM267","transmembrane protein 267",TRUE
+"238635_at",0.907964244160782,0.618090177483591,0.505658371699782,-5.81590764357311,0.554929349993942,"TMEM267","transmembrane protein 267",TRUE
+"219029_at",0.953404125808695,0.785372755334781,0.275648204226623,-5.90274309415794,0.100201969914519,"TMEM267","transmembrane protein 267",TRUE
+"221865_at",0.355028107426795,0.00954578509238231,-2.83726199311484,-2.6335864686807,-1.2762859664886,"TMEM268","transmembrane protein 268",TRUE
+"223784_at",0.767945391174396,0.270548589769822,1.1300305251206,-5.33615148145321,0.834543377933201,"TMEM27","transmembrane protein 27",TRUE
+"232591_s_at",0.546010851974392,0.0472760013396758,2.10059074063785,-3.99252260886043,0.872342832826286,"TMEM30A","transmembrane protein 30A",TRUE
+"217743_s_at",0.617775129514679,0.0884685246919267,1.78195449511928,-4.50117458087789,0.630534811748429,"TMEM30A","transmembrane protein 30A",TRUE
+"222391_at",0.804656080879986,0.343574931683149,0.967831861787241,-5.49346857302258,0.484125794265871,"TMEM30A","transmembrane protein 30A",TRUE
+"213285_at",0.932830928398943,0.703644281773304,0.385361640315847,-5.86761056164758,0.490885355773587,"TMEM30B","transmembrane protein 30B",TRUE
+"230471_at",0.956734254923335,0.803762635730555,-0.251477577333098,-5.90892799070863,-0.0736231341320077,"TMEM30B","transmembrane protein 30B",TRUE
+"231569_at",0.771855357662161,0.282031244180319,-1.10260570554652,-5.36427847767379,-0.408963897462548,"TMEM31","transmembrane protein 31",TRUE
+"222642_s_at",0.843257017684317,0.437729892652621,-0.790300031118558,-5.63997072522126,-0.274550309007724,"TMEM33","transmembrane protein 33",TRUE
+"218465_at",0.859465912277024,0.476781683976324,-0.723766694121055,-5.68771208037922,-0.238537152633775,"TMEM33","transmembrane protein 33",TRUE
+"235907_at",0.922047851621144,0.667264148972909,-0.435707767576651,-5.84763942602143,-0.13017291520738,"TMEM33","transmembrane protein 33",TRUE
+"225492_at",0.925511384407886,0.67816740588089,-0.42050436102152,-5.85392412928092,-0.145019368087542,"TMEM33","transmembrane protein 33",TRUE
+"238831_at",0.997171203405,0.985601633858683,0.0182514310835716,-5.93952123414515,0.0161276990108155,"TMEM33","transmembrane protein 33",TRUE
+"219685_at",0.636147339487472,0.107483252177777,1.67757066436034,-4.65471211436488,0.755842850506627,"TMEM35A","transmembrane protein 35A",TRUE
+"213698_at",0.717937808890208,0.193750516450193,1.34023826694675,-5.10073598008807,0.761510640779466,"TMEM35B///ZMYM6","transmembrane protein 35B///zinc finger MYM-type containing 6",TRUE
+"1554483_at",0.772417008567082,0.282705809684763,1.10102003742887,-5.36588599389995,0.617065428695598,"TMEM37","transmembrane protein 37",TRUE
+"1554485_s_at",0.866807918403275,0.49827037582184,0.688522355790655,-5.71138561213587,0.611311130104745,"TMEM37","transmembrane protein 37",TRUE
+"227190_at",0.98586793523628,0.931413044254779,-0.0870508336539695,-5.93599326444101,-0.0536328450367796,"TMEM37","transmembrane protein 37",TRUE
+"243849_at",0.995678148676256,0.979333082621827,0.0261990857206529,-5.93934916999773,0.0115380144459767,"TMEM37","transmembrane protein 37",TRUE
+"222896_at",0.962437545364198,0.828883816013342,-0.218702425010624,-5.91641370081362,-0.184398829740364,"TMEM38A","transmembrane protein 38A",TRUE
+"222735_at",0.514615584352718,0.034778318869379,-2.24902379941118,-3.73712826367,-1.15025837328314,"TMEM38B","transmembrane protein 38B",TRUE
+"222736_s_at",0.596382916302699,0.0729133970459383,-1.88287493250398,-4.34634626282054,-0.826192959973802,"TMEM38B","transmembrane protein 38B",TRUE
+"218772_x_at",0.709902278828277,0.182672430925195,-1.37567045198223,-5.05771059506005,-0.791569951811754,"TMEM38B","transmembrane protein 38B",TRUE
+"241374_at",0.820536502908875,0.379739612900593,-0.896277459151616,-5.55581486468156,-0.264549797733181,"TMEM39A","transmembrane protein 39A",TRUE
+"241392_at",0.913697616562839,0.638210831856602,0.476746651470422,-5.8295824302162,0.19603903358322,"TMEM39A","transmembrane protein 39A",TRUE
+"222690_s_at",0.936143408699214,0.714769321152604,0.370172015282717,-5.87316201503992,0.115598023132909,"TMEM39A","transmembrane protein 39A",TRUE
+"218615_s_at",0.943294768503521,0.745336166826321,0.328878075773673,-5.88713922131591,0.077781901988752,"TMEM39A","transmembrane protein 39A",TRUE
+"218770_s_at",0.813392555634619,0.363262141139007,0.928286221473647,-5.52846927962144,0.429854681904631,"TMEM39B","transmembrane protein 39B",TRUE
+"219503_s_at",0.757361197594703,0.253318364556308,1.17283246294919,-5.29103788771736,0.987466554029898,"TMEM40","transmembrane protein 40",TRUE
+"222892_s_at",0.903919439852106,0.60580195783002,0.523531184197274,-5.80706138369192,0.53138695612941,"TMEM40","transmembrane protein 40",TRUE
+"235037_at",0.582127094566663,0.0642336124649415,1.94768779676899,-4.24375723041059,0.668348121915617,"TMEM41A","transmembrane protein 41A",TRUE
+"225991_at",0.65284137151906,0.121725746932431,1.6092168639775,-4.75144362382053,0.481487269577002,"TMEM41A","transmembrane protein 41A",TRUE
+"212623_at",0.781912175977628,0.303512064211672,1.05339635059561,-5.41320285489273,0.344974105208216,"TMEM41B","transmembrane protein 41B",TRUE
+"212622_at",0.970274748961658,0.858772766352696,0.180020497855701,-5.92391135661123,0.0628454211508398,"TMEM41B","transmembrane protein 41B",TRUE
+"226361_at",0.962741248200658,0.830457882803077,0.216657280191782,-5.91684638063829,0.0840223016695187,"TMEM42","transmembrane protein 42",TRUE
+"233489_at",0.610455440146151,0.0830273346135776,1.81536881270483,-4.45059019097786,0.444713290514622,"TMEM43","transmembrane protein 43",TRUE
+"233480_at",0.908535021486648,0.619631685710391,-0.50342815143916,-5.816990476075,-0.193223860321586,"TMEM43","transmembrane protein 43",TRUE
+"217795_s_at",0.936992192746977,0.718739681587988,0.364772658925665,-5.87508228885258,0.114699919302973,"TMEM43","transmembrane protein 43",TRUE
+"222418_s_at",0.989586772349659,0.949593142774106,0.063937740236267,-5.93769254594765,0.0205647458793727,"TMEM43","transmembrane protein 43",TRUE
+"1560275_at",0.499428826990278,0.0315257858021028,2.29562893964824,-3.65476894347966,0.664671598102799,"TMEM44","transmembrane protein 44",TRUE
+"228054_at",0.721317419960934,0.197618928947629,1.32824078173893,-5.11509126709103,1.40318891940679,"TMEM44","transmembrane protein 44",TRUE
+"229754_at",0.906476756086155,0.613897674661471,0.511737203151409,-5.81293250131963,0.194313689306466,"TMEM44-AS1","TMEM44 antisense RNA 1",TRUE
+"219410_at",0.642592458809121,0.112658945923775,1.65189500392169,-4.69140831823876,2.21913181030927,"TMEM45A","transmembrane protein 45A",TRUE
+"230323_s_at",0.748184017928985,0.240601331034515,1.20583322643759,-5.2552545047162,1.69448161102994,"TMEM45B","transmembrane protein 45B",TRUE
+"226226_at",0.791646964605038,0.322213796924296,1.01253222697581,-5.45230402810174,1.10169883774788,"TMEM45B","transmembrane protein 45B",TRUE
+"209656_s_at",0.954456115752166,0.791269861098217,-0.267879797216476,-5.90479234566368,-0.39587242223848,"TMEM47","transmembrane protein 47",TRUE
+"209655_s_at",0.9882620262439,0.944086276086372,-0.0709344838898766,-5.93723302184347,-0.092202622754451,"TMEM47","transmembrane protein 47",TRUE
+"204807_at",0.258009532763673,0.00381587339558119,-3.23109136641012,-1.83447403244676,-1.37238618507844,"TMEM5","transmembrane protein 5",TRUE
+"204808_s_at",0.506052373093096,0.0331271936624614,-2.27215972102914,-3.69636785395978,-0.927387619405351,"TMEM5","transmembrane protein 5",TRUE
+"217766_s_at",0.816800680706682,0.36794500107705,0.919093014917242,-5.53641372538767,0.334676616352544,"TMEM50A","transmembrane protein 50A",TRUE
+"222401_s_at",0.979588787486838,0.902656930155572,0.123714300607998,-5.9322316167577,0.0338946813943917,"TMEM50A","transmembrane protein 50A",TRUE
+"225182_at",0.474981499638426,0.0261663333682842,-2.38303716939385,-3.49767979357566,-0.911146548387975,"TMEM50B","transmembrane protein 50B",TRUE
+"222907_x_at",0.61591966964196,0.0870182009281647,-1.79068363373612,-4.48802582544627,-0.561576357270098,"TMEM50B","transmembrane protein 50B",TRUE
+"219600_s_at",0.695005304830231,0.16449181062128,-1.43770593890827,-4.9801467911993,-0.537630431878842,"TMEM50B","transmembrane protein 50B",TRUE
+"231696_x_at",0.728385463227073,0.209843128722787,1.29149516189133,-5.15837968701753,0.595289143920107,"TMEM50B","transmembrane protein 50B",TRUE
+"228001_at",0.942303845415102,0.740568428987509,0.335278907224359,-5.88507959137505,0.104378567936338,"TMEM50B","transmembrane protein 50B",TRUE
+"218815_s_at",0.535697382361465,0.0429929604719178,2.14697037401939,-3.91388893867071,1.27318625173118,"TMEM51","transmembrane protein 51",TRUE
+"239120_at",0.0550194051692779,9.44636089965319e-05,4.75239955777034,1.4219721460309,2.77595993909175,"TMEM51-AS1","TMEM51 antisense RNA 1",TRUE
+"238641_at",0.752923567429559,0.246278648009332,1.19094306301231,-5.2715072994496,0.733688374901652,"TMEM51-AS1","TMEM51 antisense RNA 1",TRUE
+"230467_at",0.8877101263145,0.552782564428771,-0.602768961571762,-5.76425134522406,-0.24353893969483,"TMEM52","transmembrane protein 52",TRUE
+"236646_at",0.517348414110187,0.0365146752248086,2.22575034697448,-3.77787885998412,3.41001095579769,"TMEM52B","transmembrane protein 52B",TRUE
+"1554077_a_at",0.553930058946379,0.0505920089579533,2.0672093789714,-4.04843626762448,0.746690130749962,"TMEM53","transmembrane protein 53",TRUE
+"230647_at",0.612420348961838,0.0840921655047637,1.80868375130855,-4.46076485896952,1.004665530196,"TMEM53","transmembrane protein 53",TRUE
+"219462_at",0.732320150624823,0.21664372610791,1.27176599083164,-5.18119596521905,0.789283077013248,"TMEM53","transmembrane protein 53",TRUE
+"225536_at",0.841774087327031,0.433719575932141,0.797333207673013,-5.63469272599111,0.547632738059262,"TMEM54","transmembrane protein 54",TRUE
+"226338_at",0.942684843065067,0.743240340286298,0.331690043955384,-5.88623923685761,0.308694941073867,"TMEM55A","transmembrane protein 55A",TRUE
+"225287_s_at",0.998347572104896,0.992674699013639,-0.00928518383152003,-5.93964148886448,-0.00367714434606015,"TMEM55B","transmembrane protein 55B",TRUE
+"237515_at",0.64513208805899,0.116049866431609,1.63560727422832,-4.71446282831709,1.0365607326542,"TMEM56","transmembrane protein 56",TRUE
+"234980_at",0.756198431607818,0.251046882434712,1.17863464099872,-5.28480923090972,1.1119704235529,"TMEM56","transmembrane protein 56",TRUE
+"218562_s_at",0.647518308302168,0.118682894587826,-1.62323343506627,-4.73186003608414,-0.576561797350003,"TMEM57","transmembrane protein 57",TRUE
+"241364_at",0.819893682360372,0.377953367539293,-0.899702419241165,-5.552931201259,-0.338276778029465,"TMEM57","transmembrane protein 57",TRUE
+"200620_at",0.819018525257656,0.373332589508186,-0.908612114775646,-5.54538203168067,-0.371520238508429,"TMEM59","transmembrane protein 59",TRUE
+"241018_at",0.898647305933017,0.588365388394773,0.54919356934022,-5.79383680937479,0.489255924612086,"TMEM59","transmembrane protein 59",TRUE
+"219005_at",0.620344422814676,0.090246356453003,1.7714207318775,-4.51697913839828,1.17734410714468,"TMEM59L","transmembrane protein 59 like",TRUE
+"223396_at",0.971216837324271,0.862662667977359,-0.175008118534734,-5.92477678919117,-0.059971688674036,"TMEM60","transmembrane protein 60",TRUE
+"230822_at",0.803487298448767,0.341497541541232,0.972093596319318,-5.48961693730151,0.866308591563617,"TMEM61","transmembrane protein 61",TRUE
+"222739_at",0.885029460971826,0.545801358363136,0.61348729450833,-5.75801319513418,0.3790382802045,"TMEM62","transmembrane protein 62",TRUE
+"218776_s_at",0.988224361618126,0.943996012045569,-0.0710491980243284,-5.93722509071222,-0.0457169704798517,"TMEM62","transmembrane protein 62",TRUE
+"202699_s_at",0.837609393049242,0.421743601419635,0.818579403101608,-5.61848197440296,0.291250262696739,"TMEM63A","transmembrane protein 63A",TRUE
+"214833_at",0.866484787547432,0.497504957647894,0.689762578921326,-5.71057169228161,0.324108655495936,"TMEM63A","transmembrane protein 63A",TRUE
+"215583_at",0.910053424070078,0.625593340135913,0.494827132028356,-5.82112274797061,0.246110281699622,"TMEM63A","transmembrane protein 63A",TRUE
+"202700_s_at",0.91554266499988,0.643768408887433,0.468834028501531,-5.83318777639296,0.172352710182853,"TMEM63A","transmembrane protein 63A",TRUE
+"225271_at",0.702630084418366,0.174248390294781,-1.4037709379163,-5.02292551744898,-0.559469626959062,"TMEM63B","transmembrane protein 63B",TRUE
+"227733_at",0.812302873476553,0.359783861692805,-0.93516605236432,-5.52247639940342,-0.858940923867483,"TMEM63C","transmembrane protein 63C",TRUE
+"242338_at",0.936963138658766,0.717666432433923,-0.366231091569893,-5.87456634468995,-0.402327306456893,"TMEM64","transmembrane protein 64",TRUE
+"225974_at",0.946145819241213,0.756051410016435,-0.314543071283768,-5.89160930468881,-0.326126445055742,"TMEM64","transmembrane protein 64",TRUE
+"225972_at",0.95194340202313,0.780333416826784,-0.28230039104043,-5.90094207960851,-0.232707409883643,"TMEM64","transmembrane protein 64",TRUE
+"241342_at",0.892625092437988,0.564991128084292,-0.584193747668071,-5.77481066825939,-0.448935061489706,"TMEM65","transmembrane protein 65",TRUE
+"238045_at",0.950926616697165,0.775937716973805,-0.288113573135827,-5.89933332661773,-0.181208761247133,"TMEM65","transmembrane protein 65",TRUE
+"1569377_at",0.612866720637562,0.0844730426469989,-1.80631035777096,-4.46437064057459,-1.29990387972994,"TMEM67","transmembrane protein 67",TRUE
+"232023_at",0.729083413548563,0.210661969873686,-1.28909371930044,-5.16117287323178,-0.485285179170058,"TMEM67","transmembrane protein 67",TRUE
+"238229_at",0.817055852876968,0.369480127453118,0.916096290553576,-5.53898764710036,0.518331319575553,"TMEM67","transmembrane protein 67",TRUE
+"1563646_a_at",0.886186292065379,0.549005982347298,0.608558274658325,-5.76089509700103,0.250590079895056,"TMEM67","transmembrane protein 67",TRUE
+"1569411_at",0.888686718625571,0.554977778777908,-0.599413341528447,-5.76618252419135,-0.67791055450386,"TMEM67","transmembrane protein 67",TRUE
+"1552765_x_at",0.903636519547706,0.605085260487628,0.524578888410757,-5.80653352791844,0.232113498411188,"TMEM67","transmembrane protein 67",TRUE
+"1552763_at",0.993409125631259,0.96891684394217,-0.039409515508209,-5.93892704648544,-0.0386096893153471,"TMEM67","transmembrane protein 67",TRUE
+"227936_at",0.746259710622309,0.23771830114685,-1.21349609117441,-5.24682208128625,-0.588249838345128,"TMEM68","transmembrane protein 68",TRUE
+"226483_at",0.890353193998525,0.558801460485768,-0.593584937531998,-5.76951204821959,-0.297447518579723,"TMEM68","transmembrane protein 68",TRUE
+"223335_at",0.989586772349659,0.949248324597188,0.0643757489147036,-5.93766517724999,0.0218354170047732,"TMEM69","transmembrane protein 69",TRUE
+"219449_s_at",0.792344934473527,0.323502806991359,-1.00977762179077,-5.4548895059628,-0.390548113462504,"TMEM70","transmembrane protein 70",TRUE
+"226083_at",0.854400503339099,0.465809206235551,-0.742120619951174,-5.67493904186113,-0.232009160913513,"TMEM70","transmembrane protein 70",TRUE
+"219448_at",0.897560972979555,0.584358667211174,-0.555142930745009,-5.79068314372865,-0.397810019239296,"TMEM70","transmembrane protein 70",TRUE
+"238429_at",0.013935242387053,8.41084588518972e-06,5.75577918866928,3.52707384066396,5.31405037281376,"TMEM71","transmembrane protein 71",TRUE
+"1558323_at",0.922168942129244,0.667584708475127,0.435259307565659,-5.84782794575712,0.313923667358816,"TMEM72","transmembrane protein 72",TRUE
+"1558324_a_at",0.926430328514448,0.680136172954158,0.417769942492352,-5.85503119306565,0.246873558107442,"TMEM72","transmembrane protein 72",TRUE
+"1563632_at",0.51470556386048,0.035188343219864,2.24343403154595,-3.74693887582111,1.14619582271069,"TMEM72-AS1","TMEM72 antisense RNA 1",TRUE
+"1552521_a_at",0.69410086222651,0.163515138538646,1.44119123297457,-4.97570584814843,1.62529875881536,"TMEM74","transmembrane protein 74",TRUE
+"1555159_at",0.701591887097885,0.173194068590035,1.40736361826298,-5.01843632044947,0.545261362016777,"TMEM74","transmembrane protein 74",TRUE
+"1552520_at",0.990623482682449,0.952581300192618,0.060142531252644,-5.93792186653651,0.0237281952305493,"TMEM74","transmembrane protein 74",TRUE
+"219958_at",0.953902670233338,0.787234391174877,0.273193975115992,-5.9033967873335,0.181050590426821,"TMEM74B","transmembrane protein 74B",TRUE
+"1559611_at",0.903919439852106,0.605599942213882,0.523826440693328,-5.80691273115936,0.430947916734208,"TMEM75","transmembrane protein 75",TRUE
+"223544_at",0.831875452294783,0.406770788249672,-0.845681787330628,-5.59722385754616,-0.58779303268485,"TMEM79","transmembrane protein 79",TRUE
+"1559132_at",0.646692716816097,0.117747160418916,-1.62760427659596,-4.72572639901413,-0.604105380024803,"TMEM80","transmembrane protein 80",TRUE
+"65630_at",0.874834820370747,0.521454893844119,-0.651452228266312,-5.73506612388757,-0.346131952939745,"TMEM80","transmembrane protein 80",TRUE
+"221951_at",0.895999830738594,0.576884553622195,0.566295422462243,-5.78468255148952,0.231952174088496,"TMEM80","transmembrane protein 80",TRUE
+"242103_at",0.744931128252932,0.236688496753725,-1.21625022434292,-5.24378005131988,-0.628475188253721,"TMEM86A","transmembrane protein 86A",TRUE
+"227570_at",0.849935057946582,0.45224736650436,-0.765164596352594,-5.65847307628478,-0.581223530388627,"TMEM86A","transmembrane protein 86A",TRUE
+"238710_at",0.897401619272848,0.583994660130969,-0.555684426770211,-5.79039446711002,-0.318691814378653,"TMEM86A","transmembrane protein 86A",TRUE
+"229736_at",0.902064015083249,0.600485082633195,0.531317899361952,-5.80311371495134,0.24240387224339,"TMEM86B","transmembrane protein 86B",TRUE
+"223772_s_at",0.894992610442074,0.572435145627057,-0.572969134440132,-5.78103642964588,-0.21331019120245,"TMEM87A","transmembrane protein 87A",TRUE
+"223771_at",0.94630837494651,0.756911437507311,0.313395464774319,-5.89195863496333,0.244550610048423,"TMEM87A","transmembrane protein 87A",TRUE
+"212202_s_at",0.949038895598021,0.77030540665476,0.295577011404578,-5.89722019325282,0.128648358790647,"TMEM87A","transmembrane protein 87A",TRUE
+"212204_at",0.974536463688956,0.875559293139455,0.158422050843673,-5.92746677934515,0.0628412602223083,"TMEM87A","transmembrane protein 87A",TRUE
+"225411_at",0.735677568529031,0.220690903802314,-1.26025000393698,-5.19437523927767,-0.577754562706977,"TMEM87B","transmembrane protein 87B",TRUE
+"225412_at",0.795924451457704,0.328158298058888,-0.999892009377806,-5.46411558761208,-0.480940207743474,"TMEM87B","transmembrane protein 87B",TRUE
+"229452_at",0.936992192746977,0.718474163684551,-0.365133394654742,-5.87495486192809,-0.289498893440666,"TMEM88","transmembrane protein 88",TRUE
+"222718_at",0.920486752529216,0.661403291747108,0.443923198530998,-5.84415217552857,0.15449663389499,"TMEM8A","transmembrane protein 8A",TRUE
+"221882_s_at",0.937271400689562,0.721962552896488,0.360397941604212,-5.87661772238305,0.181059393367496,"TMEM8A","transmembrane protein 8A",TRUE
+"207839_s_at",0.906026109953261,0.612537407490332,-0.513713687152735,-5.81195768912166,-0.253853345811031,"TMEM8B","transmembrane protein 8B",TRUE
+"229729_at",0.979588787486838,0.902795551532407,-0.123537185324405,-5.93225293053328,-0.109258636905384,"TMEM8B","transmembrane protein 8B",TRUE
+"222988_s_at",0.429284714913652,0.018848367412656,-2.5339748300557,-3.21888616932436,-1.2294950646224,"TMEM9","transmembrane protein 9",TRUE
+"222987_s_at",0.547195868806649,0.0476688417581357,-2.09652836641587,-3.99935791141714,-0.941153482670144,"TMEM9","transmembrane protein 9",TRUE
+"229957_at",0.966269294084641,0.842611566591084,-0.200897383255227,-5.92004482725198,-0.137648454234934,"TMEM91","transmembrane protein 91",TRUE
+"235245_at",0.411110107932987,0.016151006562146,2.60388079587217,-3.08677401936306,1.47438350896349,"TMEM92","transmembrane protein 92",TRUE
+"231408_at",0.557502997422893,0.0522058978842683,2.05166634246306,-4.07427207490247,0.637574755559331,"TMEM92","transmembrane protein 92",TRUE
+"216789_at",0.622434989367596,0.0930137251559255,1.75537350639841,-4.54092371985801,0.843620376538026,"TMEM92-AS1","TMEM92 antisense RNA 1",TRUE
+"216427_at",0.959649219607517,0.817911289956755,0.23298580700239,-5.9132790620849,0.127003828973806,"TMEM92-AS1","TMEM92 antisense RNA 1",TRUE
+"1560281_a_at",0.916107385524794,0.646295399644639,0.465246266960945,-5.83480305714341,0.246638165292333,"TMEM95","transmembrane protein 95",TRUE
+"212282_at",0.522832264420585,0.0386422529588219,-2.19856881879099,-3.82514687796481,-0.659592269137564,"TMEM97","transmembrane protein 97",TRUE
+"212281_s_at",0.539114280228505,0.0441853312658111,-2.13365472944306,-3.93657601816614,-0.661044105453716,"TMEM97","transmembrane protein 97",TRUE
+"214283_at",0.607125171829172,0.0808500846106667,-1.82927208029497,-4.42934288400014,-0.514903749165731,"TMEM97","transmembrane protein 97",TRUE
+"212279_at",0.632949074657601,0.104127763423934,-1.6947811374042,-4.62987465223618,-0.512497189207664,"TMEM97","transmembrane protein 97",TRUE
+"223170_at",0.564724082922135,0.056064422900802,2.01617677334938,-4.13278177739521,2.90481378921645,"TMEM98","transmembrane protein 98",TRUE
+"226565_at",0.957174671135192,0.805942354884927,0.248623083210197,-5.90962120053995,0.0840816490432363,"TMEM99","transmembrane protein 99",TRUE
+"222507_s_at",0.819018525257656,0.374389445778526,-0.906567909141575,-5.54712015737772,-0.335772526047046,"TMEM9B","TMEM9 domain family member B",TRUE
+"218065_s_at",0.86688231622194,0.498423639556523,-0.688274149569985,-5.71154833413355,-0.259072022480023,"TMEM9B","TMEM9 domain family member B",TRUE
+"242243_at",0.813065886130395,0.362878831994081,0.929042215285996,-5.52781273876652,0.512114155088333,"TMF1","TATA element modulatory factor 1",TRUE
+"214948_s_at",0.888365275629554,0.55445106941414,-0.600217839011267,-5.76572048003379,-0.304596177688504,"TMF1","TATA element modulatory factor 1",TRUE
+"215855_s_at",0.904204980173804,0.606579670890897,0.522394954881222,-5.80763267860151,0.183245567018707,"TMF1","TATA element modulatory factor 1",TRUE
+"227685_at",0.960116489822537,0.819404767226323,0.231038838571436,-5.91371795612375,0.101952684863342,"TMF1","TATA element modulatory factor 1",TRUE
+"213024_at",0.961690794738111,0.826476330300573,-0.221832259318268,-5.91574370498202,-0.0859017613504012,"TMF1","TATA element modulatory factor 1",TRUE
+"235566_at",0.973493137611142,0.872350329098551,-0.162544594780641,-5.92682309708415,-0.0692432736446911,"TMF1","TATA element modulatory factor 1",TRUE
+"1553601_a_at",0.502810516099457,0.0325167751756957,2.28098060683151,-3.68076241034654,1.68408987448569,"TMIE","transmembrane inner ear",TRUE
+"1553600_at",0.695744345349551,0.16528328062132,1.43489374297838,-4.98372367347172,1.16732629960242,"TMIE","transmembrane inner ear",TRUE
+"244716_x_at",0.901218079288909,0.597878046126517,0.5351481306206,-5.8011510738038,0.28111605571713,"TMIGD2","transmembrane and immunoglobulin domain containing 2",TRUE
+"222744_s_at",0.865885012497452,0.496242415657468,0.691810678110477,-5.70922452618607,0.796375595033087,"TMLHE","trimethyllysine hydroxylase, epsilon",TRUE
+"218790_s_at",0.929829824527542,0.69038842395658,-0.403582252403836,-5.86066118178306,-0.370698035533925,"TMLHE","trimethyllysine hydroxylase, epsilon",TRUE
+"1554206_at",0.942684843065067,0.7430507335907,0.331944573301816,-5.88615739927715,0.263165139220703,"TMLHE","trimethyllysine hydroxylase, epsilon",TRUE
+"203661_s_at",0.760227035076299,0.258114911164696,1.1607063453454,-5.30396841301935,0.496381309070339,"TMOD1","tropomodulin 1",TRUE
+"203662_s_at",0.784925710185113,0.310266382231745,1.03843837324535,-5.42767724660484,0.794190495309662,"TMOD1","tropomodulin 1",TRUE
+"219701_at",0.84571977676742,0.443383235433224,-0.780452298692129,-5.64728688475975,-0.664624877760861,"TMOD2","tropomodulin 2",TRUE
+"226186_at",0.915520482335079,0.643736066262273,0.468879988195303,-5.8331670056242,0.474794345152986,"TMOD2","tropomodulin 2",TRUE
+"223078_s_at",0.705559553212919,0.177586667296622,1.39250869938337,-5.03693673163384,0.639598587250562,"TMOD3","tropomodulin 3",TRUE
+"220800_s_at",0.710824498521146,0.184043621232164,1.37119434296977,-5.06319759154998,0.609072224962826,"TMOD3","tropomodulin 3",TRUE
+"223077_at",0.861388867330702,0.481913443548341,0.715267735172371,-5.69352376682083,0.291471467775395,"TMOD3","tropomodulin 3",TRUE
+"242316_at",0.892856334334787,0.566320227315092,0.582184115494645,-5.77593390831997,0.210025896554689,"TMOD3","tropomodulin 3",TRUE
+"223762_at",0.873301865850313,0.518263341233688,0.656499979504751,-5.73191545589992,0.487631465249022,"TMOD4///VPS72","tropomodulin 4///vacuolar protein sorting 72 homolog",TRUE
+"237863_at",0.620912785033482,0.0905767351630533,-1.76948291425579,-4.51987911152275,-1.68936911961522,"TMPO","thymopoietin",TRUE
+"224944_at",0.726696341943087,0.20660277830376,-1.30107000737058,-5.14719903504694,-0.390182141090616,"TMPO","thymopoietin",TRUE
+"203432_at",0.869715052099024,0.507336011065821,-0.673914450422395,-5.72086693487492,-0.196839535293025,"TMPO","thymopoietin",TRUE
+"209754_s_at",0.97268653850474,0.867937048999191,-0.168219048308639,-5.92591013088437,-0.08297754070907,"TMPO","thymopoietin",TRUE
+"209753_s_at",0.983783029912313,0.92089972891665,-0.100438213465801,-5.93477126253508,-0.0396182923088588,"TMPO","thymopoietin",TRUE
+"227578_at",0.99753019043878,0.987575758054066,-0.0157487893148262,-5.93956267794755,-0.00592698323393748,"TMPO-AS1","TMPO antisense RNA 1",TRUE
+"201576_s_at",0.979588787486838,0.902091176889525,-0.124437200549271,-5.93214430792108,-0.058154940112729,"TMPPE///GLB1","transmembrane protein with metallophosphoesterase domain///galactosidase beta 1",TRUE
+"1560712_at",0.831487912516861,0.405972893940935,0.847143692782625,-5.59605881019255,0.325428269731542,"TMPRSS11B","transmembrane protease, serine 11B",TRUE
+"207602_at",0.861659105448003,0.483536781276484,0.71259022551303,-5.69534114680115,0.357373913393327,"TMPRSS11D","transmembrane protease, serine 11D",TRUE
+"220431_at",0.21219412234776,0.00249637213878491,3.4093338766788,-1.46215563284719,3.61343080546053,"TMPRSS11E","transmembrane protease, serine 11E",TRUE
+"1569176_at",0.674680903837191,0.141046611047935,1.52645327375981,-4.86436458436515,0.735422400205252,"TMPRSS12","transmembrane protease, serine 12",TRUE
+"223956_at",0.662855903464759,0.130559678628148,-1.57011792673091,-4.80537261636986,-1.0112713532905,"TMPRSS13","transmembrane protease, serine 13",TRUE
+"223659_at",0.974895849298463,0.877486502710123,-0.155947526943682,-5.92784522234476,-0.156207322434949,"TMPRSS13","transmembrane protease, serine 13",TRUE
+"207638_at",0.614178202960275,0.0851285263845202,-1.80224735688698,-4.4705354055486,-1.46091090222403,"TMPRSS15","transmembrane protease, serine 15",TRUE
+"217269_s_at",0.920147736488699,0.660023389650072,0.445861971770398,-5.84331989153635,0.135321717452724,"TMPRSS15","transmembrane protease, serine 15",TRUE
+"205102_at",0.585036027492332,0.0654205849933479,-1.93838586906651,-4.25862815800385,-1.49443002447768,"TMPRSS2","transmembrane protease, serine 2",TRUE
+"226553_at",0.725583196024696,0.204556013758369,-1.30717813428015,-5.14002993719869,-1.24230505207739,"TMPRSS2","transmembrane protease, serine 2",TRUE
+"211689_s_at",0.803203434524165,0.341194729120153,-0.972716290246208,-5.48905287099954,-1.31880178365192,"TMPRSS2","transmembrane protease, serine 2",TRUE
+"1570433_at",0.953983577550391,0.788425456295342,0.271624671437505,-5.90381173497167,0.173624049121661,"TMPRSS2","transmembrane protease, serine 2",TRUE
+"223949_at",0.636147339487472,0.10758502980052,1.67705579248793,-4.6554522026876,2.22318856068761,"TMPRSS3","transmembrane protease, serine 3",TRUE
+"223948_s_at",0.654623800601032,0.123609256834112,1.6006867509089,-4.76329724524529,2.07206728470549,"TMPRSS3","transmembrane protease, serine 3",TRUE
+"220177_s_at",0.812302873476553,0.358162259336748,0.938388741687943,-5.51965519824692,1.05638375069655,"TMPRSS3","transmembrane protease, serine 3",TRUE
+"218960_at",0.603702127972549,0.0779199995202282,1.84850475567954,-4.39975976515901,2.62555811144622,"TMPRSS4","transmembrane protease, serine 4",TRUE
+"221032_s_at",0.539551372174552,0.0442594952757726,2.13283726178667,-3.93796591246246,0.919723970236076,"TMPRSS5","transmembrane protease, serine 5",TRUE
+"232941_at",0.588467901034655,0.0671211559081731,1.92531479469932,-4.2794419940505,1.10952967784141,"TMPRSS6","transmembrane protease, serine 6",TRUE
+"234367_x_at",0.716776486570264,0.192792227005072,1.34323929519619,-5.09712823385782,0.497692915501045,"TMPRSS6","transmembrane protease, serine 6",TRUE
+"214955_at",0.872540606821582,0.515769679441242,-0.660455910762608,-5.729429969595,-0.432593155543147,"TMPRSS6","transmembrane protease, serine 6",TRUE
+"217733_s_at",0.699391325858549,0.170891821095039,1.41526985882855,-5.0085238945794,0.372921948055573,"TMSB10","thymosin beta 10",TRUE
+"1570039_at",0.959593724813212,0.817617260028004,-0.233369226753581,-5.9131921981351,-0.211191940614586,"TMSB15B","thymosin beta 15B",TRUE
+"205347_s_at",0.697172073261335,0.166778101831198,-1.42961185553283,-4.99042631937135,-1.32489210034324,"TMSB15B///TMSB15A","thymosin beta 15B///thymosin beta 15a",TRUE
+"214051_at",0.845790310351117,0.443786601250166,0.77975260781787,-5.64780341527114,0.816507114818374,"TMSB15B///TMSB15A","thymosin beta 15B///thymosin beta 15a",TRUE
+"216438_s_at",0.988404376556799,0.944674009685759,-0.0701875728929872,-5.93728434871506,-0.0207042196562401,"TMSB4X","thymosin beta 4, X-linked",TRUE
+"206769_at",0.855557411779543,0.468804470828337,0.737085272424875,-5.67847350640144,0.580551984766668,"TMSB4Y","thymosin beta 4, Y-linked",TRUE
+"226322_at",0.818854105808043,0.37277144386945,-0.909699057247864,-5.54445636602597,-1.66133004960646,"TMTC1","transmembrane and tetratricopeptide repeat containing 1",TRUE
+"226931_at",0.822010986888098,0.385551907080428,-0.88520555562469,-5.5650672462563,-1.07761728549776,"TMTC1","transmembrane and tetratricopeptide repeat containing 1",TRUE
+"224397_s_at",0.833226189657242,0.410601064982809,-0.838689250168888,-5.60277049094093,-1.41981956569728,"TMTC1","transmembrane and tetratricopeptide repeat containing 1",TRUE
+"244506_at",0.941311073534434,0.737372199501064,-0.339577936474587,-5.88367422482306,-0.283735802630322,"TMTC1","transmembrane and tetratricopeptide repeat containing 1",TRUE
+"235775_at",0.98539961718117,0.928619336895401,-0.0906065743316784,-5.93568570189358,-0.0611632118433985,"TMTC2","transmembrane and tetratricopeptide repeat containing 2",TRUE
+"228574_at",0.988419329021919,0.944786589999282,0.0700445068469357,-5.93729411807939,0.0400762980883975,"TMTC2","transmembrane and tetratricopeptide repeat containing 2",TRUE
+"1560017_at",0.612420348961838,0.0842404253728879,1.80775878372623,-4.46217052447542,0.91353197464228,"TMTC3","transmembrane and tetratricopeptide repeat containing 3",TRUE
+"226600_at",0.9116561917482,0.630553548632503,0.487699676976887,-5.82449436094965,0.214557964479789,"TMTC3","transmembrane and tetratricopeptide repeat containing 3",TRUE
+"226604_at",0.949216032237554,0.770669267710619,0.295094341383674,-5.89735847315098,0.155673311836141,"TMTC3","transmembrane and tetratricopeptide repeat containing 3",TRUE
+"1554102_a_at",0.835513930382091,0.414901406374942,0.830887734027188,-5.6089080327474,0.395386198890941,"TMTC4","transmembrane and tetratricopeptide repeat containing 4",TRUE
+"1554101_a_at",0.87927534655779,0.533176006693731,-0.633057895871925,-5.74634966144114,-0.332686344218088,"TMTC4","transmembrane and tetratricopeptide repeat containing 4",TRUE
+"225666_at",0.985425981490741,0.928938622852845,0.0902001377590001,-5.93572148034476,0.0542452763330612,"TMTC4","transmembrane and tetratricopeptide repeat containing 4",TRUE
+"223153_x_at",0.612420348961838,0.0841883347093805,-1.80808360780917,-4.46167695125551,-0.525883113685087,"TMUB1","transmembrane and ubiquitin like domain containing 1",TRUE
+"218419_s_at",0.928591109195268,0.686079002193048,-0.409535460084155,-5.85832212020811,-0.153773877617212,"TMUB2","transmembrane and ubiquitin like domain containing 2",TRUE
+"209476_at",0.906476756086155,0.613595164411067,-0.512176575273813,-5.81271611739539,-0.136163826826253,"TMX1","thioredoxin related transmembrane protein 1",TRUE
+"208097_s_at",0.941408730862225,0.738115514564128,-0.338577574863664,-5.884002827212,-0.159171533460986,"TMX1","thioredoxin related transmembrane protein 1",TRUE
+"201175_at",0.885029460971826,0.545863981665528,-0.613390827351863,-5.75806981271115,-0.215872826431601,"TMX2","thioredoxin related transmembrane protein 2",TRUE
+"208862_s_at",0.589837057564116,0.0680402802388089,1.91837095360449,-4.29045950976974,0.694543164022472,"TMX2-CTNND1///CTNND1","TMX2-CTNND1 readthrough (NMD candidate)///catenin delta 1",TRUE
+"1557944_s_at",0.590117758431162,0.0681266262682669,1.9177228659763,-4.29148639830261,0.827651518315445,"TMX2-CTNND1///CTNND1","TMX2-CTNND1 readthrough (NMD candidate)///catenin delta 1",TRUE
+"208407_s_at",0.622753941247615,0.0932374343167287,1.75409425408073,-4.54282563017827,0.856196882403685,"TMX2-CTNND1///CTNND1","TMX2-CTNND1 readthrough (NMD candidate)///catenin delta 1",TRUE
+"211240_x_at",0.647754107214051,0.119105476086363,1.62126900273274,-4.73461259582234,0.600393437690203,"TMX2-CTNND1///CTNND1","TMX2-CTNND1 readthrough (NMD candidate)///catenin delta 1",TRUE
+"225302_at",0.921462951426584,0.665223041807832,0.438565394778418,-5.84643368486385,0.400912100066366,"TMX3","thioredoxin related transmembrane protein 3",TRUE
+"1552822_at",0.997056683282451,0.984986397565019,-0.0190314036602954,-5.93950707078698,-0.0161427713289815,"TMX3","thioredoxin related transmembrane protein 3",TRUE
+"216027_at",0.860026478479837,0.478559887844707,-0.720815706632155,-5.68973739895362,-0.628932432435358,"TMX4","thioredoxin related transmembrane protein 4",TRUE
+"201581_at",0.901781358899845,0.59904821485911,-0.53342793206225,-5.80203421402275,-0.666882027055014,"TMX4","thioredoxin related transmembrane protein 4",TRUE
+"201580_s_at",0.975475861996229,0.882976002742098,0.148904452429276,-5.92888982276732,0.134541527701973,"TMX4","thioredoxin related transmembrane protein 4",TRUE
+"1555707_at",0.937655803006818,0.724241731715455,0.357308515593763,-5.87769102351719,0.263798649993629,"TNAP","TRAFs and NIK-associated protein",TRUE
+"216005_at",0.817815704063733,0.370414048384715,0.914277227355405,-5.54054628204305,0.629510615416493,"TNC","tenascin C",TRUE
+"201645_at",0.821962235882611,0.38518852045728,0.885894560812573,-5.56449457875647,1.70181953042178,"TNC","tenascin C",TRUE
+"237169_at",0.900535738777606,0.595505442577406,0.538640988674602,-5.79934935177321,0.383990142120752,"TNC","tenascin C",TRUE
+"207113_s_at",0.411110107932987,0.0161479311139408,2.60396657460839,-3.08661081313746,1.56513763887943,"TNF","tumor necrosis factor",TRUE
+"201208_s_at",0.746535697909741,0.238307535832922,1.21192427703102,-5.24855552330816,0.358516441242587,"TNFAIP1","TNF alpha induced protein 1",TRUE
+"201207_at",0.92777930247318,0.683005173030813,0.413790976143424,-5.85662944055196,0.119193449068487,"TNFAIP1","TNF alpha induced protein 1",TRUE
+"202509_s_at",0.314126572995991,0.00667476829318922,2.99260499585845,-2.3228930997333,2.42710969961652,"TNFAIP2","TNF alpha induced protein 2",TRUE
+"202510_s_at",0.396346452385611,0.0136791176159424,2.67833272116174,-2.94414629359026,3.04388591179269,"TNFAIP2","TNF alpha induced protein 2",TRUE
+"202644_s_at",0.00821792329303558,3.15640400829899e-06,6.17365492206702,4.36710209027467,3.95911589457669,"TNFAIP3","TNF alpha induced protein 3",TRUE
+"202643_s_at",0.0560907825756854,0.000109770713042494,4.69095854148453,1.29012406150113,4.00914878550387,"TNFAIP3","TNF alpha induced protein 3",TRUE
+"206026_s_at",0.868397087637799,0.504097556812365,0.67911568062018,-5.71751334306974,0.635029025459457,"TNFAIP6","TNF alpha induced protein 6",TRUE
+"206025_s_at",0.958792863216689,0.813365556461486,0.23891754772004,-5.911919320793,0.117787982544979,"TNFAIP6","TNF alpha induced protein 6",TRUE
+"208296_x_at",0.308621629697291,0.00627170345366633,3.01941067121716,-2.26864149614836,2.02905565232417,"TNFAIP8","TNF alpha induced protein 8",TRUE
+"210260_s_at",0.322131160460075,0.00726687736448107,2.9559187113189,-2.39684929189461,2.22918948827294,"TNFAIP8","TNF alpha induced protein 8",TRUE
+"229814_at",0.65284137151906,0.121812915209072,1.60881966894729,-4.75199665885314,1.17349585693226,"TNFAIP8","TNF alpha induced protein 8",TRUE
+"227420_at",0.813442508625161,0.363672908584295,0.927476664142406,-5.52917179243638,0.472241349152057,"TNFAIP8L1","TNF alpha induced protein 8 like 1",TRUE
+"223583_at",0.642021982677251,0.112340636639657,-1.65344504622619,-4.68920519967681,-0.742744236585768,"TNFAIP8L2","TNF alpha induced protein 8 like 2",TRUE
+"218672_at",0.8111749793648,0.355197339868927,-0.944306543672316,-5.51445144906109,-0.305864861912518,"TNFAIP8L2-SCNM1///SCNM1","TNFAIP8L2-SCNM1 readthrough///sodium channel modifier 1",TRUE
+"234279_at",0.958264946445917,0.811269645013052,-0.241655450012781,-5.9112802405272,-0.135925668700925,"TNFAIP8L3","TNF alpha induced protein 8 like 3",TRUE
+"231775_at",0.809930331505913,0.35356785573308,0.947573087976371,-5.51156620045552,0.433717606147734,"TNFRSF10A","TNF receptor superfamily member 10a",TRUE
+"241371_at",0.812644903778517,0.361268896089251,0.932223313849839,-5.52504473732559,0.281786247892324,"TNFRSF10A","TNF receptor superfamily member 10a",TRUE
+"1552648_a_at",0.83949628091616,0.425996616851443,0.810991745540461,-5.62431725045655,0.34735799175505,"TNFRSF10A","TNF receptor superfamily member 10a",TRUE
+"209294_x_at",0.784515251996446,0.307776448276802,1.04392546113121,-5.42238917553213,0.805890839060304,"TNFRSF10B","TNF receptor superfamily member 10b",TRUE
+"210405_x_at",0.786455312223125,0.312124728913237,1.03436333885804,-5.43158823649962,0.923762068642752,"TNFRSF10B","TNF receptor superfamily member 10b",TRUE
+"209295_at",0.875520432940449,0.522942309621147,0.649105545584742,-5.73652291099672,0.504488727539325,"TNFRSF10B","TNF receptor superfamily member 10b",TRUE
+"1556645_s_at",0.909208120822242,0.62315054250703,0.498346802566576,-5.81944016151581,0.297790450696671,"TNFRSF10B","TNF receptor superfamily member 10b",TRUE
+"234644_x_at",0.852006864319744,0.457209733440257,-0.756685208497128,-5.66458738703049,-0.777439480156519,"TNFRSF10C","TNF receptor superfamily member 10c",TRUE
+"211163_s_at",0.931370027472813,0.696731720652485,0.394846217471742,-5.86403258268811,0.450955206630918,"TNFRSF10C","TNF receptor superfamily member 10c",TRUE
+"206222_at",0.956734254923335,0.803967815301988,0.251208789697386,-5.90899360085936,0.206058566694787,"TNFRSF10C","TNF receptor superfamily member 10c",TRUE
+"234195_at",0.994114182402977,0.972968232807465,0.034270606344784,-5.93911145373291,0.0137506011631432,"TNFRSF10C","TNF receptor superfamily member 10c",TRUE
+"210654_at",0.741057455414442,0.231269563086175,1.23089400404638,-5.22750540012281,1.52676438798394,"TNFRSF10D","TNF receptor superfamily member 10d",TRUE
+"227345_at",0.984236975186631,0.922996992108466,0.097766191682881,-5.93502909225322,0.118098434233269,"TNFRSF10D","TNF receptor superfamily member 10d",TRUE
+"238846_at",0.831487912516861,0.405862671967586,0.847345786058367,-5.59589760678108,0.51864656746848,"TNFRSF11A","TNF receptor superfamily member 11a",TRUE
+"207037_at",0.870433264908839,0.508911677788748,0.671390541935093,-5.72248538059037,0.634275999794272,"TNFRSF11A","TNF receptor superfamily member 11a",TRUE
+"204933_s_at",0.296090407530139,0.00530975618248029,3.09075321805596,-2.1234134717181,5.33150942885592,"TNFRSF11B","TNF receptor superfamily member 11b",TRUE
+"204932_at",0.41173827666364,0.0163845979110028,2.5974099769357,-3.09907805271271,3.70435465234417,"TNFRSF11B","TNF receptor superfamily member 11b",TRUE
+"218368_s_at",0.949217179291784,0.770839488895719,0.294868563661827,-5.89742307916859,0.147029162606779,"TNFRSF12A","TNF receptor superfamily member 12A",TRUE
+"207641_at",0.915939421175188,0.645155861669297,-0.466863385846106,-5.83407650244929,-0.139534875434465,"TNFRSF13B","TNF receptor superfamily member 13B",TRUE
+"1552892_at",0.6287528932499,0.0998049090397421,1.7176613035152,-4.59655996910887,0.510092083422721,"TNFRSF13C","TNF receptor superfamily member 13C",TRUE
+"209354_at",0.747978851178392,0.239859409194527,1.20779855416205,-5.25309622255563,1.11811831833822,"TNFRSF14","TNF receptor superfamily member 14",TRUE
+"206641_at",0.68865058167867,0.157906277908628,1.46153827111965,-4.94960509241122,1.0808226361092,"TNFRSF17","TNF receptor superfamily member 17",TRUE
+"223851_s_at",0.784918343662568,0.309574294259077,1.03996040261237,-5.42621293552757,0.438988139566962,"TNFRSF18","TNF receptor superfamily member 18",TRUE
+"224553_s_at",0.876632890672003,0.525555536429982,0.6449915309607,-5.73906464962346,0.355878909582856,"TNFRSF18","TNF receptor superfamily member 18",TRUE
+"227812_at",0.755049574909504,0.248990718748971,1.18392067761037,-5.27911128572107,1.08126325863921,"TNFRSF19","TNF receptor superfamily member 19",TRUE
+"224090_s_at",0.790240875783718,0.31947840216793,1.01840331764042,-5.44677214200629,0.569622809429172,"TNFRSF19","TNF receptor superfamily member 19",TRUE
+"223827_at",0.902212740485572,0.600753943627097,-0.530923349691396,-5.80331510606456,-0.322180911056987,"TNFRSF19","TNF receptor superfamily member 19",TRUE
+"207643_s_at",0.88113080359582,0.537563651632219,0.62622871565457,-5.75045972420609,0.28573808062459,"TNFRSF1A","TNF receptor superfamily member 1A",TRUE
+"203508_at",0.62179111032845,0.0921560669676193,1.76030249737463,-4.53358606363924,1.4460774302853,"TNFRSF1B","TNF receptor superfamily member 1B",TRUE
+"214581_x_at",0.171589157517339,0.00148837281696855,3.62420151574672,-1.00710234918479,3.59866445732686,"TNFRSF21","TNF receptor superfamily member 21",TRUE
+"218856_at",0.178066946115198,0.00160804325616825,3.59220689658706,-1.07521735772606,3.23020091652955,"TNFRSF21","TNF receptor superfamily member 21",TRUE
+"210847_x_at",0.538502554109027,0.043910230270042,2.1366978568553,-3.93139900439681,1.95288992226933,"TNFRSF25","TNF receptor superfamily member 25",TRUE
+"219423_x_at",0.538508613666048,0.0439795702670498,2.13592921067361,-3.93270707624926,1.39442186538745,"TNFRSF25","TNF receptor superfamily member 25",TRUE
+"211282_x_at",0.696129677967645,0.166179811495136,1.43172130420977,-4.98775188197277,0.679428051701498,"TNFRSF25","TNF receptor superfamily member 25",TRUE
+"216042_at",0.71454754703986,0.18969603544063,1.35301629668525,-5.08532774217221,0.795963188833493,"TNFRSF25","TNF receptor superfamily member 25",TRUE
+"211841_s_at",0.756584150514497,0.251837508024712,1.17661067851942,-5.28698501237843,0.815645879425928,"TNFRSF25","TNF receptor superfamily member 25",TRUE
+"208023_at",0.767965891104819,0.270733009811134,1.12958340953461,-5.33661494658307,0.807083271974903,"TNFRSF4","TNF receptor superfamily member 4",TRUE
+"214228_x_at",0.993952584307899,0.971668195961373,-0.0359195041447983,-5.93905508618729,-0.0158140462611351,"TNFRSF4","TNF receptor superfamily member 4",TRUE
+"206729_at",0.627092759817312,0.0986898431685671,1.72369987755226,-4.58771177285884,0.787661815018854,"TNFRSF8","TNF receptor superfamily member 8",TRUE
+"207536_s_at",0.676475496596199,0.143498176671655,1.51663286252858,-4.87745026171525,0.584161982258677,"TNFRSF9","TNF receptor superfamily member 9",TRUE
+"211786_at",0.71242055183987,0.186595844503064,1.36293264909145,-5.07328600362924,1.05637904105945,"TNFRSF9","TNF receptor superfamily member 9",TRUE
+"238950_at",0.94630837494651,0.756905916679864,0.313402830304373,-5.89195639693613,0.153607187925139,"TNFRSF9","TNF receptor superfamily member 9",TRUE
+"214329_x_at",0.593339168375633,0.070053744449988,1.90344293160735,-4.31405163899873,2.4598209752504,"TNFSF10","tumor necrosis factor superfamily member 10",TRUE
+"202687_s_at",0.597654932724127,0.0743430073816139,1.87285578429722,-4.36198845635967,2.50844300744006,"TNFSF10","tumor necrosis factor superfamily member 10",TRUE
+"202688_at",0.622434989367596,0.0928322791049372,1.75641302179961,-4.53937748238082,2.54750900516175,"TNFSF10","tumor necrosis factor superfamily member 10",TRUE
+"210643_at",0.477266692481162,0.0264894334102267,2.37731988288942,-3.50805634658494,1.87255658024021,"TNFSF11","tumor necrosis factor superfamily member 11",TRUE
+"211153_s_at",0.975196332002567,0.879575649259094,-0.153266202178013,-5.92824858278439,-0.0876121110754853,"TNFSF11","tumor necrosis factor superfamily member 11",TRUE
+"205611_at",0.606900628956089,0.0806605519305391,1.83049768251713,-4.42746430611306,1.54601430852753,"TNFSF12-TNFSF13///TNFSF12","TNFSF12-TNFSF13 readthrough///tumor necrosis factor superfamily member 12",TRUE
+"229326_at",0.978197434639598,0.89417200284425,-0.134563361964167,-5.93086792979878,-0.0835622702190131,"TNFSF12-TNFSF13///TNFSF12///TNFSF13","TNFSF12-TNFSF13 readthrough///tumor necrosis factor superfamily member 12///tumor necrosis factor superfamily member 13",TRUE
+"209499_x_at",0.900171779891306,0.594848818932601,0.539608842488563,-5.79884808669654,0.33246648212678,"TNFSF12-TNFSF13///TNFSF13","TNFSF12-TNFSF13 readthrough///tumor necrosis factor superfamily member 13",TRUE
+"209500_x_at",0.920169584950428,0.660282194035462,0.445498217521644,-5.84347631652431,0.301402678844317,"TNFSF12-TNFSF13///TNFSF13","TNFSF12-TNFSF13 readthrough///tumor necrosis factor superfamily member 13",TRUE
+"211495_x_at",0.939229539590199,0.728038173157243,0.352170280688105,-5.8794558879224,0.197143526430102,"TNFSF12-TNFSF13///TNFSF13","TNFSF12-TNFSF13 readthrough///tumor necrosis factor superfamily member 13",TRUE
+"210314_x_at",0.888583087185673,0.554732629445059,0.599787733698162,-5.76596757533677,0.550537915368647,"TNFSF13","tumor necrosis factor superfamily member 13",TRUE
+"223501_at",0.668518995965071,0.134642603293668,1.55278506387087,-4.82894695700053,0.917416656634557,"TNFSF13B","tumor necrosis factor superfamily member 13b",TRUE
+"223502_s_at",0.839466826665106,0.425937254018716,0.81109732628307,-5.62423640345855,0.539163375157144,"TNFSF13B","tumor necrosis factor superfamily member 13b",TRUE
+"207907_at",0.705853136697393,0.178220405846545,1.39038974878755,-5.03956246230801,0.430490537312664,"TNFSF14","tumor necrosis factor superfamily member 14",TRUE
+"233935_at",0.877948371309952,0.529577703247303,0.638681195045406,-5.74293315378236,0.405387249191488,"TNFSF14","tumor necrosis factor superfamily member 14",TRUE
+"221085_at",0.657015752622694,0.125790680817401,1.59094186797407,-4.77677897664904,1.09486632998869,"TNFSF15","tumor necrosis factor superfamily member 15",TRUE
+"229242_at",0.726082405428554,0.205135709495288,1.305443357047,-5.14206893356017,0.899492632915964,"TNFSF15","tumor necrosis factor superfamily member 15",TRUE
+"221371_at",0.78885145722244,0.315083383335186,1.02791062455778,-5.43775282777209,0.502608647199075,"TNFSF18","tumor necrosis factor superfamily member 18",TRUE
+"207426_s_at",0.72140144244575,0.197664654947961,1.32810007097721,-5.11525898686629,0.805900273380826,"TNFSF4","tumor necrosis factor superfamily member 4",TRUE
+"235735_at",0.663129351367592,0.131139004463488,1.56763148723305,-4.80876704972841,1.15457574381905,"TNFSF8","tumor necrosis factor superfamily member 8",TRUE
+"207216_at",0.762857166457304,0.262643287748092,-1.14941049855368,-5.31590748742996,-0.655640261656,"TNFSF8","tumor necrosis factor superfamily member 8",TRUE
+"241819_at",0.94943075115007,0.771457155165943,0.294049435690299,-5.89765705994798,0.260061473278996,"TNFSF8","tumor necrosis factor superfamily member 8",TRUE
+"206907_at",0.995810088048184,0.979817118914467,-0.0255853398424637,-5.93936464957058,-0.0164710630093481,"TNFSF9","tumor necrosis factor superfamily member 9",TRUE
+"213109_at",0.840872144163754,0.430300239509101,-0.803361739289871,-5.63013366310867,-0.555048750637407,"TNIK","TRAF2 and NCK interacting kinase",TRUE
+"211828_s_at",0.929972194057784,0.691054433927913,0.402663527488355,-5.86101915304243,0.595758646782793,"TNIK","TRAF2 and NCK interacting kinase",TRUE
+"239288_at",0.93423034725099,0.70888012896852,-0.378201571282971,-5.8702548299379,-0.305871711274531,"TNIK","TRAF2 and NCK interacting kinase",TRUE
+"213107_at",0.985872346401724,0.931507369275044,0.0869308001374847,-5.93600343237715,0.0732890021065717,"TNIK","TRAF2 and NCK interacting kinase",TRUE
+"207196_s_at",0.194294573776651,0.00202040475751077,3.49749769808601,-1.27615572218564,1.18670319832221,"TNIP1","TNFAIP3 interacting protein 1",TRUE
+"243423_at",0.662855903464759,0.130856682757095,-1.56884205916836,-4.80711493069458,-1.03688902287217,"TNIP1","TNFAIP3 interacting protein 1",TRUE
+"232160_s_at",0.258009532763673,0.00381764448113052,-3.23089529260659,-1.83488050215173,-1.68718293721098,"TNIP2","TNFAIP3 interacting protein 2",TRUE
+"48531_at",0.528176582660474,0.0407603237064044,-2.17282613540233,-3.86958404135721,-0.67041551629975,"TNIP2","TNFAIP3 interacting protein 2",TRUE
+"218335_x_at",0.567651250567208,0.0577766086594404,-2.00112101330042,-4.15739839919519,-0.587882220109547,"TNIP2","TNFAIP3 interacting protein 2",TRUE
+"220655_at",0.803583569469174,0.341991461938587,0.971078723912562,-5.4905355515241,1.1144635083282,"TNIP3","TNFAIP3 interacting protein 3",TRUE
+"205793_x_at",0.945764550538403,0.755100889717093,0.315811931611337,-5.89122159267194,0.0869874702370286,"TNK1","tyrosine kinase non receptor 1",TRUE
+"217149_x_at",0.969450447163359,0.854588078681891,-0.185418006372637,-5.92295218928439,-0.0566917068923409,"TNK1","tyrosine kinase non receptor 1",TRUE
+"203838_s_at",0.661974206478491,0.129470152027206,1.57481900845878,-4.79894327064122,1.65368163164487,"TNK2","tyrosine kinase non receptor 2",TRUE
+"203839_s_at",0.693850056112024,0.163089373192484,1.44271584348393,-4.97376043910908,0.648567496783603,"TNK2","tyrosine kinase non receptor 2",TRUE
+"1555557_a_at",0.72050514215489,0.196391206849704,-1.33202835822749,-5.11057105948613,-1.03026717441393,"TNK2","tyrosine kinase non receptor 2",TRUE
+"216439_at",0.928167838756364,0.684284972069408,0.412018237970153,-5.85733665903921,0.14047443057559,"TNK2","tyrosine kinase non receptor 2",TRUE
+"1565784_at",0.907189812622248,0.615945201625039,-0.508766008178782,-5.81439101557941,-0.29054551814245,"TNK2-AS1","TNK2 antisense RNA 1",TRUE
+"216695_s_at",0.725181883744124,0.203698854187147,1.30975025653914,-5.13700253759985,0.864705902028773,"TNKS","tankyrase",TRUE
+"217121_at",0.872668627020452,0.516047973260099,0.660013902589587,-5.72970839101396,0.517809975464987,"TNKS","tankyrase",TRUE
+"202561_at",0.916006170428115,0.645401110258844,0.466515246880079,-5.8342331261878,0.172677971437512,"TNKS","tankyrase",TRUE
+"1569391_at",0.997039490727282,0.984845924411869,-0.0192094917238274,-5.9395037538252,-0.0167065580222392,"TNKS","tankyrase",TRUE
+"224792_at",0.971242929121865,0.863634794699015,-0.173756194513792,-5.92498914254654,-0.0779038591534267,"TNKS1BP1","tankyrase 1 binding protein 1",TRUE
+"222562_s_at",0.852994610926182,0.459116672834013,0.753441465674942,-5.6669093371947,0.309693928983139,"TNKS2","tankyrase 2",TRUE
+"222563_s_at",0.88819967763925,0.553671877742957,0.601408712039064,-5.76503543152928,0.218017834254125,"TNKS2","tankyrase 2",TRUE
+"218228_s_at",0.94118897722809,0.736543372082558,0.340693798392128,-5.88330655133578,0.120326888522209,"TNKS2","tankyrase 2",TRUE
+"241909_at",0.972680171456902,0.867894470433791,0.1682738216976,-5.92590116612672,0.167570562340589,"TNKS2","tankyrase 2",TRUE
+"220065_at",0.835083899263907,0.413945017610433,0.832618335688067,-5.60755117707084,0.431864288444103,"TNMD","tenomodulin",TRUE
+"215271_at",0.992869121264064,0.966319973476445,-0.0427040309262241,-5.93879529477293,-0.0295947691604095,"TNN","tenascin N",TRUE
+"209904_at",0.987257510450304,0.9405625324526,-0.0754134545803457,-5.93691384019669,-0.128955705772961,"TNNC1","troponin C1, slow skeletal and cardiac type",TRUE
+"205388_at",0.768040047226182,0.271198557873775,1.12845570706774,-5.33778316573427,0.798793345614857,"TNNC2","troponin C2, fast skeletal type",TRUE
+"205177_at",0.937757781799543,0.724534278953871,0.356912225069235,-5.87782803883093,0.140988240689393,"TNNI1","troponin I1, slow skeletal type",TRUE
+"206393_at",0.937856707467078,0.725076716049337,-0.356177582631461,-5.87808164020648,-0.412185200111721,"TNNI2","troponin I2, fast skeletal type",TRUE
+"205742_at",0.970540753946729,0.859902801246128,0.178563897180272,-5.92416536303675,0.126086435304823,"TNNI3","troponin I3, cardiac type",TRUE
+"241858_at",0.838503236630356,0.423553404467438,-0.815344775054032,-5.62097579112117,-0.473103266472485,"TNNI3K","TNNI3 interacting kinase",TRUE
+"213201_s_at",0.895758940460776,0.576557050864036,-0.566785758611622,-5.78441607013251,-0.678505050624652,"TNNT1","troponin T1, slow skeletal type",TRUE
+"1563655_at",0.334088804451308,0.00823077493545334,2.90191753855979,-2.50507021252121,1.31781710515937,"TNNT2","troponin T2, cardiac type",TRUE
+"215389_s_at",0.51531387545335,0.0358624986353819,-2.23437120910727,-3.76281391669941,-1.31646796775327,"TNNT2","troponin T2, cardiac type",TRUE
+"1569986_x_at",0.636147339487472,0.107542771755708,1.67726951710826,-4.65514501103996,0.900505663318728,"TNNT3","troponin T3, fast skeletal type",TRUE
+"205693_at",0.813442508625161,0.363946085308485,0.926938614667257,-5.52963838585813,0.398720094203972,"TNNT3","troponin T3, fast skeletal type",TRUE
+"206568_at",0.844029183111344,0.440361709692441,0.785705950050972,-5.64339455213186,0.365646892514789,"TNP1","transition protein 1",TRUE
+"207736_s_at",0.81125719016705,0.355309772107594,0.944081529736914,-5.5146498612986,0.433540598957873,"TNP2","transition protein 2",TRUE
+"217460_at",0.997447988915405,0.987012867751077,-0.0164623668263405,-5.93955148286523,-0.0116250538355929,"TNP2","transition protein 2",TRUE
+"225765_at",0.830635993561085,0.404420001087519,-0.849994178163899,-5.59378175385649,-0.241158391194411,"TNPO1","transportin 1",TRUE
+"212635_at",0.913233126230689,0.636159831891238,-0.479674562671073,-5.82823337908355,-0.226073900556996,"TNPO1","transportin 1",TRUE
+"1557278_s_at",0.920606794805399,0.662348596017558,0.442596036071122,-5.84471985309332,0.501979670336504,"TNPO1","transportin 1",TRUE
+"209226_s_at",0.939610295972262,0.729226953616662,0.350563335395008,-5.88000265140258,0.12414357004678,"TNPO1","transportin 1",TRUE
+"243324_x_at",0.954449231029359,0.790840143476468,-0.268445300751227,-5.90464513281959,-0.207638784612636,"TNPO1","transportin 1",TRUE
+"207657_x_at",0.955816406528307,0.798730455394971,0.25807577570538,-5.90729552837324,0.0965002345536075,"TNPO1","transportin 1",TRUE
+"221829_s_at",0.96635324070119,0.843162509481052,0.200184228310726,-5.92018387398233,0.0770747980660627,"TNPO1","transportin 1",TRUE
+"209225_x_at",0.98451040420843,0.92437879415227,-0.096006104058772,-5.93519513303127,-0.0316436908506326,"TNPO1","transportin 1",TRUE
+"225766_s_at",0.991689960875868,0.961445914888488,-0.048888834843257,-5.93851940936008,-0.0141339104269882,"TNPO1","transportin 1",TRUE
+"1556116_s_at",0.993083193605528,0.967251299374921,-0.0415224521043276,-5.93884376326299,-0.0372799605195917,"TNPO1","transportin 1",TRUE
+"215844_at",0.498206796273596,0.0311532954027898,-2.30124417992953,-3.64477891923872,-1.34347027076266,"TNPO2","transportin 2",TRUE
+"221506_s_at",0.683300986833698,0.152387601490573,1.48213738692733,-4.92287904446192,0.576690987470904,"TNPO2","transportin 2",TRUE
+"210585_s_at",0.789595899448337,0.316796237273046,1.0241943911776,-5.44128732580889,0.857690236254165,"TNPO2","transportin 2",TRUE
+"221507_at",0.903919439852106,0.605716295128575,0.523656379006147,-5.80699836193699,0.163870714870326,"TNPO2","transportin 2",TRUE
+"226428_at",0.908013878860707,0.618445886326363,0.505143509679979,-5.81615803768025,0.243102760521312,"TNPO2","transportin 2",TRUE
+"214550_s_at",0.778974960380281,0.300085604316081,1.06107496779367,-5.40570029146239,0.332105988962828,"TNPO3","transportin 3",TRUE
+"212317_at",0.861659105448003,0.482866440358087,0.713695242423151,-5.6945918944958,0.192626293272124,"TNPO3","transportin 3",TRUE
+"212318_at",0.897011777275924,0.582665779076352,0.557662695089276,-5.78933751188744,0.184515188764129,"TNPO3","transportin 3",TRUE
+"1564897_at",0.569521899903848,0.0588844499342744,-1.99158923494738,-4.1729192637853,-1.53033184944623,"TNR","tenascin R",TRUE
+"213841_at",0.622917527985155,0.0936343545130137,1.75183097883878,-4.54618801725061,0.614134600556646,"TNR","tenascin R",TRUE
+"206990_at",0.837368340567858,0.420667820354356,-0.820506250274544,-5.61699202585958,-0.272917950105092,"TNR","tenascin R",TRUE
+"244882_at",0.604682600348682,0.0787387637876249,1.84306808037537,-4.40814469612095,0.677242338496018,"TNRC18","trinucleotide repeat containing 18",TRUE
+"1558949_at",0.867717011547419,0.500687384176047,0.68461311637324,-5.71394196664284,0.26852366547694,"TNRC18","trinucleotide repeat containing 18",TRUE
+"1558238_at",0.886374687477145,0.549197032762538,-0.608264901420791,-5.76106591944356,-0.423939157669023,"TNRC18","trinucleotide repeat containing 18",TRUE
+"242187_s_at",0.915746779716325,0.644659397490241,0.46756831350438,-5.83375901321084,0.277894969826654,"TNRC18","trinucleotide repeat containing 18",TRUE
+"1562896_at",0.925440584489504,0.676913028896282,0.422248264359509,-5.8532143800264,0.108604908731655,"TNRC18","trinucleotide repeat containing 18",TRUE
+"235755_at",0.957243533506016,0.806508461154219,0.247882073828479,-5.90979986753964,0.120700712868022,"TNRC18","trinucleotide repeat containing 18",TRUE
+"229257_at",0.962555471240652,0.829370777561514,0.218069626791411,-5.9165480107132,0.0923784203563542,"TNRC18","trinucleotide repeat containing 18",TRUE
+"226691_at",0.979803152416153,0.903810082531579,0.122241051035445,-5.93240797727819,0.0494352038923811,"TNRC18","trinucleotide repeat containing 18",TRUE
+"233836_at",0.622917527985155,0.0937226132487621,1.75132883728668,-4.54693357901663,1.12384532700953,"TNRC6A","trinucleotide repeat containing 6A",TRUE
+"224705_s_at",0.695739345331756,0.165111904517293,-1.43550174419674,-4.98295083074938,-0.363928119393044,"TNRC6A","trinucleotide repeat containing 6A",TRUE
+"234734_s_at",0.802145448110055,0.33981331264975,-0.97556180095735,-5.48647107707845,-0.296847976640354,"TNRC6A","trinucleotide repeat containing 6A",TRUE
+"224704_at",0.819780516863333,0.377643629090559,-0.900297397093102,-5.55242921970542,-0.220179951928438,"TNRC6A","trinucleotide repeat containing 6A",TRUE
+"243834_at",0.843257017684317,0.437695077987197,0.790360916912491,-5.63992522273082,0.52640696070296,"TNRC6A","trinucleotide repeat containing 6A",TRUE
+"1553346_a_at",0.896458677219354,0.58107640413465,0.560031711878747,-5.78806699069115,0.244200354594875,"TNRC6A","trinucleotide repeat containing 6A",TRUE
+"240044_x_at",0.783844746433788,0.306691162102127,1.04632693883375,-5.42006691205894,0.420347500841752,"TNRC6B","trinucleotide repeat containing 6B",TRUE
+"229036_at",0.797752695752955,0.331342770331118,0.993185901206513,-5.47032738856349,0.334639027913006,"TNRC6B","trinucleotide repeat containing 6B",TRUE
+"228998_at",0.81035488031479,0.354141540329452,0.946421894500415,-5.51258406033589,0.597855068938727,"TNRC6B","trinucleotide repeat containing 6B",TRUE
+"213254_at",0.819479221404744,0.376680921592254,0.902148720906606,-5.55086529955307,0.268059704958524,"TNRC6B","trinucleotide repeat containing 6B",TRUE
+"238468_at",0.893175412268596,0.567572196064292,0.580293317881299,-5.7769873079976,0.300448467900276,"TNRC6B","trinucleotide repeat containing 6B",TRUE
+"1558142_at",0.893462835798285,0.568330936200784,0.579148462401281,-5.77762351668611,0.252553857765482,"TNRC6B","trinucleotide repeat containing 6B",TRUE
+"230779_at",0.93303499530294,0.704225974415481,0.384565163679887,-5.86790712351061,0.216636764787008,"TNRC6B","trinucleotide repeat containing 6B",TRUE
+"222820_at",0.0533112880354026,8.02351310597656e-05,-4.81926071049656,1.56518156861988,-2.55154623287499,"TNRC6C","trinucleotide repeat containing 6C",TRUE
+"1561041_at",0.317600554649094,0.00693092578116442,-2.97636558791901,-2.3556725982136,-1.70576074182939,"TNRC6C","trinucleotide repeat containing 6C",TRUE
+"233359_at",0.6287528932499,0.0998704447924328,-1.71730819096713,-4.5970766599944,-0.933847803221588,"TNRC6C","trinucleotide repeat containing 6C",TRUE
+"1569482_at",0.675334226639578,0.141502128950764,-1.52461803333345,-4.86681514846495,-1.54049938692813,"TNRC6C","trinucleotide repeat containing 6C",TRUE
+"227149_at",0.829485424009328,0.400801442210421,-0.856663680462718,-5.5884260935769,-0.331355204839612,"TNRC6C","trinucleotide repeat containing 6C",TRUE
+"228591_at",0.868055236465056,0.502018654254711,-0.6824645048128,-5.71534107623525,-0.223556805387546,"TNRC6C","trinucleotide repeat containing 6C",TRUE
+"242314_at",0.999614041775554,0.999138688047412,0.00109173962824595,-5.93968290022081,0.000480878886072844,"TNRC6C","trinucleotide repeat containing 6C",TRUE
+"242364_x_at",0.956960361976289,0.80487705709202,0.250017899625382,-5.90928345408992,0.0728360651079232,"TNRC6C-AS1","TNRC6C antisense RNA 1",TRUE
+"239062_at",0.973493137611142,0.8723770088035,0.162510307675041,-5.92682851859301,0.163902543311288,"TNRC6C-AS1","TNRC6C antisense RNA 1",TRUE
+"230526_at",0.986342822130003,0.93470087018184,0.0828676636653559,-5.93633934744048,0.0415147195413299,"TNRC6C-AS1","TNRC6C antisense RNA 1",TRUE
+"218864_at",0.70772084164277,0.179313452089096,-1.38674910741045,-5.04406608896023,-1.1244560278264,"TNS1","tensin 1",TRUE
+"221748_s_at",0.904450326858676,0.608376217117174,-0.519772879200804,-5.80894644093114,-0.640249457951026,"TNS1","tensin 1",TRUE
+"221246_x_at",0.945644577306271,0.75469789702025,-0.316350050743902,-5.89105669855351,-0.19311872182137,"TNS1","tensin 1",TRUE
+"218863_s_at",0.966313390701604,0.843021169146334,-0.200367172807682,-5.92014825151798,-0.133258161338962,"TNS1","tensin 1",TRUE
+"221747_at",0.966593471043185,0.844078428418493,-0.19899887361628,-5.9204138976571,-0.151008654805359,"TNS1","tensin 1",TRUE
+"212494_at",0.513365264670114,0.0344966434823594,-2.25289875296546,-3.73031876179858,-1.20138571415062,"TNS2","tensin 2",TRUE
+"217853_at",0.724067243569133,0.20143102894424,1.31659629095751,-5.12892021256264,1.09274787185719,"TNS3","tensin 3",TRUE
+"234257_at",0.869971289491322,0.507930185956239,0.672962183414952,-5.72147825492259,0.516772577726797,"TNS3","tensin 3",TRUE
+"222265_at",0.585036027492332,0.065337491845581,1.93903218166285,-4.25759648234535,1.26064624995997,"TNS4","tensin 4",TRUE
+"230398_at",0.61760967235709,0.0880592736494254,1.78440511132767,-4.49748793229202,2.40601213498266,"TNS4","tensin 4",TRUE
+"1565242_at",0.51531387545335,0.0358909319437762,2.23399239535924,-3.76347663055987,1.55154560614492,"TNXB","tenascin XB",TRUE
+"217413_s_at",0.726636642789909,0.206256150036364,1.30210112995839,-5.14599080419848,0.799530017177783,"TNXB","tenascin XB",TRUE
+"216654_at",0.849646596450765,0.450973296914267,0.767350692288908,-5.65688628716869,0.555425261042732,"TNXB","tenascin XB",TRUE
+"211611_s_at",0.940227139261806,0.732451506850405,0.346209234155638,-5.88147171498737,0.321510435173375,"TNXB///ATF6B","tenascin XB///activating transcription factor 6 beta",TRUE
+"206093_x_at",0.597575993849919,0.0735343628097348,1.87850211752253,-4.35318045696364,0.9876832947653,"TNXB///TNXA","tenascin XB///tenascin XA (pseudogene)",TRUE
+"208609_s_at",0.700061364939874,0.171925540571171,1.41170945218514,-5.01299339917342,0.691274115507603,"TNXB///TNXA","tenascin XB///tenascin XA (pseudogene)",TRUE
+"216333_x_at",0.8288884913487,0.399560667776605,0.858959488622036,-5.58657352161718,0.457388376491518,"TNXB///TNXA","tenascin XB///tenascin XA (pseudogene)",TRUE
+"216339_s_at",0.918583761142768,0.654114733408382,0.454183460058537,-5.83970721422339,0.171875710223332,"TNXB///TNXA","tenascin XB///tenascin XA (pseudogene)",TRUE
+"213451_x_at",0.954900985681446,0.79458939633403,0.263514317131923,-5.90591839749538,0.167433206802899,"TNXB///TNXA","tenascin XB///tenascin XA (pseudogene)",TRUE
+"202704_at",0.610033432202476,0.0824876087304239,-1.81878562436845,-4.44537934867782,-1.1918383019563,"TOB1","transducer of ERBB2, 1",TRUE
+"228834_at",0.718812966125406,0.194837117993431,-1.33684946676776,-5.10480175272194,-1.30008709978396,"TOB1","transducer of ERBB2, 1",TRUE
+"241405_at",0.622026794278124,0.0922744539606216,-1.75961978787872,-4.53460329863398,-0.783348436765621,"TOB1-AS1","TOB1 antisense RNA 1",TRUE
+"234720_s_at",0.56861088242915,0.0584972468922176,-1.9949024694521,-4.16752986957493,-1.12656754783866,"TOB2","transducer of ERBB2, 2",TRUE
+"221496_s_at",0.863918945062466,0.490085225608722,0.701841812770931,-5.70257135961462,0.49075258350241,"TOB2","transducer of ERBB2, 2",TRUE
+"222243_s_at",0.974688014513995,0.876354606410489,-0.157400752218412,-5.9276236926544,-0.0512712571754772,"TOB2","transducer of ERBB2, 2",TRUE
+"204080_at",0.913299709879835,0.636339833929086,0.479417430249848,-5.82835217785323,0.148696017832965,"TOE1","target of EGR1, member 1 (nuclear)",TRUE
+"237342_at",0.950214160603623,0.774132851181009,-0.290503381733053,-5.89866253047196,-0.177428466558329,"TOLLIP","toll interacting protein",TRUE
+"222469_s_at",0.952914447461733,0.784431155946186,0.276890190074726,-5.90241007496496,0.108825392443148,"TOLLIP","toll interacting protein",TRUE
+"217930_s_at",0.972624640038332,0.867579399993954,0.16867914708614,-5.9258347360813,0.0645555919571681,"TOLLIP","toll interacting protein",TRUE
+"233881_s_at",0.980264692225439,0.907951795924572,-0.116951922378413,-5.93302374701873,-0.044136824539347,"TOLLIP","toll interacting protein",TRUE
+"1555865_at",0.505067985736837,0.0328976601325872,-2.27545903320276,-3.69053506007296,-1.45718619350798,"TOLLIP-AS1","TOLLIP antisense RNA 1 (head to head)",TRUE
+"202807_s_at",0.740476003158683,0.229468274147561,-1.23581930320352,-5.22199379543078,-0.432448304189696,"TOM1","target of myb1 membrane trafficking protein",TRUE
+"240261_at",0.714846001190098,0.190646467332256,-1.35000180261858,-5.08897376777804,-0.843641749665286,"TOM1L1","target of myb1 like 1 membrane trafficking protein",TRUE
+"204485_s_at",0.844608293507187,0.441479602377625,-0.783759660535327,-5.64483939136761,-0.539293904620875,"TOM1L1","target of myb1 like 1 membrane trafficking protein",TRUE
+"214840_at",0.882386660118517,0.539922189561316,-0.62257013005951,-5.75264394514595,-0.382080893039624,"TOM1L2","target of myb1 like 2 membrane trafficking protein",TRUE
+"226198_at",0.915766032166572,0.64473103654235,-0.467466578639935,-5.83380486208537,-0.138610443431737,"TOM1L2","target of myb1 like 2 membrane trafficking protein",TRUE
+"237109_at",0.927552865877291,0.682406127152086,0.414621219285944,-5.85629719535879,0.164309829137934,"TOM1L2","target of myb1 like 2 membrane trafficking protein",TRUE
+"200662_s_at",0.790309297261437,0.319955268716582,-1.01737727881917,-5.44774098730439,-0.347029670843135,"TOMM20","translocase of outer mitochondrial membrane 20",TRUE
+"212773_s_at",0.976371465776674,0.88732690149628,0.143327704162395,-5.92968277573798,0.047558765400014,"TOMM20","translocase of outer mitochondrial membrane 20",TRUE
+"229076_s_at",0.758722841981575,0.255827377365241,1.16646837961018,-5.29783882196347,0.391700825726433,"TOMM22","translocase of outer mitochondrial membrane 22",TRUE
+"217960_s_at",0.899998627338565,0.594256279150081,0.540482685393914,-5.79839475961897,0.271399994659706,"TOMM22","translocase of outer mitochondrial membrane 22",TRUE
+"222474_s_at",0.958931830316768,0.813977155969953,-0.238118964143461,-5.91210436172483,-0.102907291294613,"TOMM22","translocase of outer mitochondrial membrane 22",TRUE
+"201870_at",0.940227139261806,0.732849756058154,0.34567195462829,-5.88165173396977,0.117426788543876,"TOMM34","translocase of outer mitochondrial membrane 34",TRUE
+"202264_s_at",0.8017109011727,0.339065616839939,-0.97710524881267,-5.48506779667193,-0.352180093793889,"TOMM40","translocase of outer mitochondrial membrane 40",TRUE
+"226059_at",0.879665002659836,0.534225845698213,-0.631421118067856,-5.74733864581474,-0.67130270710264,"TOMM40L","translocase of outer mitochondrial membrane 40 like",TRUE
+"225036_at",0.902810270244072,0.602451988661012,0.528433458829565,-5.80458266933216,0.160138627760048,"TOMM5","translocase of outer mitochondrial membrane 5",TRUE
+"228053_s_at",0.937623890519979,0.723667631851867,0.358086372707657,-5.8774216469062,0.117785164911188,"TOMM5","translocase of outer mitochondrial membrane 5",TRUE
+"223516_s_at",0.877333806479767,0.526978739308172,-0.642755682197143,-5.74043950054318,-0.198608714951733,"TOMM6///PRICKLE4","translocase of outer mitochondrial membrane 6///prickle planar cell polarity protein 4",TRUE
+"218233_s_at",0.922253982025599,0.66827871437038,-0.434288709789248,-5.84823530449919,-0.108480600126407,"TOMM6///PRICKLE4","translocase of outer mitochondrial membrane 6///prickle planar cell polarity protein 4",TRUE
+"201519_at",0.794742935157907,0.326851205120452,-1.00265764086114,-5.46154276135653,-0.329969493563333,"TOMM70","translocase of outer mitochondrial membrane 70",TRUE
+"201512_s_at",0.99186228645105,0.962457259941336,-0.0476053635687423,-5.93857972415825,-0.0122319956689552,"TOMM70","translocase of outer mitochondrial membrane 70",TRUE
+"207137_at",0.823074246722209,0.389805522216509,0.877171724956546,-5.57171407234171,0.637502413739379,"TONSL","tonsoku-like, DNA repair protein",TRUE
+"1558329_at",0.925820623036756,0.678883652275583,0.41950919094353,-5.85432785830834,0.16239816872244,"TONSL","tonsoku-like, DNA repair protein",TRUE
+"1558330_x_at",0.929972194057784,0.690843781062795,0.402954073615913,-5.86090603170927,0.272938433135002,"TONSL","tonsoku-like, DNA repair protein",TRUE
+"240617_at",0.771623843789204,0.281085237726663,-1.10483407463903,-5.36201593134177,-0.640795167334241,"TONSL-AS1","TONSL antisense RNA 1",TRUE
+"208901_s_at",0.661974206478491,0.129499257667839,-1.57469299778415,-4.79911580328961,-0.576740275921896,"TOP1","topoisomerase (DNA) I",TRUE
+"208900_s_at",0.745001525353357,0.236735567191493,-1.21612414086923,-5.24391944507007,-0.525324859833818,"TOP1","topoisomerase (DNA) I",TRUE
+"225802_at",0.587626678796111,0.0667400045158149,1.92821888158865,-4.27482603728602,1.15085601769282,"TOP1MT","topoisomerase (DNA) I, mitochondrial",TRUE
+"1560757_at",0.610033432202476,0.0822463887477983,-1.8203189659924,-4.44303861704928,-0.964108482578988,"TOP1MT","topoisomerase (DNA) I, mitochondrial",TRUE
+"1566833_x_at",0.641880516735663,0.112219115172784,1.65403778451535,-4.68836230701658,1.35895573161185,"TOP1P2","topoisomerase (DNA) I pseudogene 2",TRUE
+"1566832_at",0.796466121438385,0.329264265987596,-0.99755789043651,-5.46628196522019,-0.744131303858038,"TOP1P2","topoisomerase (DNA) I pseudogene 2",TRUE
+"201291_s_at",0.868045863234681,0.501934521557649,0.682600195772049,-5.71525284282894,0.24257481784802,"TOP2A","topoisomerase (DNA) II alpha",TRUE
+"237469_at",0.89316156038085,0.567057403947192,0.581070528615048,-5.77655471044007,0.325489542524243,"TOP2A","topoisomerase (DNA) II alpha",TRUE
+"201292_at",0.940227139261806,0.732645739660381,0.345947180961427,-5.88155955213232,0.126800484227987,"TOP2A","topoisomerase (DNA) II alpha",TRUE
+"211987_at",0.899808883319249,0.59334180130349,-0.541832139983314,-5.79769329662917,-0.201575591661143,"TOP2B","topoisomerase (DNA) II beta",TRUE
+"214300_s_at",0.62110896023334,0.0913484026943332,1.76498029732491,-4.52660835213602,0.68327021792437,"TOP3A","topoisomerase (DNA) III alpha",TRUE
+"204946_s_at",0.81035488031479,0.354210446043567,0.946283708476931,-5.51270616511509,0.342458946440052,"TOP3A","topoisomerase (DNA) III alpha",TRUE
+"214299_at",0.823074246722209,0.389735236511234,0.877304009111418,-5.57160508173483,0.299285779341018,"TOP3A","topoisomerase (DNA) III alpha",TRUE
+"213660_s_at",0.771534633613556,0.280885173883454,-1.1053060324274,-5.36153621433589,-0.434443757460627,"TOP3B","topoisomerase (DNA) III beta",TRUE
+"215781_s_at",0.778686132916778,0.299169879139278,-1.06313765040291,-5.40367657699987,-0.307027928123734,"TOP3B","topoisomerase (DNA) III beta",TRUE
+"202633_at",0.975159323713639,0.87901446662949,-0.1539863407763,-5.92814093550848,-0.0412969360762236,"TOPBP1","topoisomerase (DNA) II binding protein 1",TRUE
+"204071_s_at",0.948109877411639,0.764330752854316,-0.303512881989355,-5.89491452487807,-0.126371527508592,"TOPORS","TOP1 binding arginine/serine rich protein",TRUE
+"221979_at",0.85815038001314,0.473799460840542,-0.728730295745635,-5.68428772872615,-0.491854680052761,"TOPORS-AS1","TOPORS antisense RNA 1",TRUE
+"78383_at",0.993432824584085,0.968992809581305,-0.0393131487370478,-5.9389307411917,-0.0135379115387657,"TOPORS-AS1","TOPORS antisense RNA 1",TRUE
+"202349_at",0.300851187527495,0.00572814058008455,-3.05831027438724,-2.18960340732438,-0.994423978453279,"TOR1A","torsin family 1 member A",TRUE
+"202348_s_at",0.562643595171948,0.0552632532209022,-2.02336261902256,-4.1209894108797,-0.648070529314769,"TOR1A","torsin family 1 member A",TRUE
+"1554849_at",0.737123149977386,0.222621846805183,-1.25481261531521,-5.20056228102265,-0.717415311742272,"TOR1A","torsin family 1 member A",TRUE
+"1560724_at",0.947062793209778,0.759783328611334,-0.309566360394167,-5.89311505897282,-0.153079776143696,"TOR1AIP1","torsin 1A interacting protein 1",TRUE
+"212409_s_at",0.954506242294505,0.791572419535756,0.267481687274066,-5.90489579740246,0.0812181717735676,"TOR1AIP1","torsin 1A interacting protein 1",TRUE
+"216100_s_at",0.975196332002567,0.87954722215749,0.153302679307713,-5.92824314223957,0.0595843305573691,"TOR1AIP1","torsin 1A interacting protein 1",TRUE
+"212408_at",0.976335130930535,0.885736976180044,-0.145365035866879,-5.929396590727,-0.0486021990603902,"TOR1AIP1","torsin 1A interacting protein 1",TRUE
+"240310_at",0.985577528508055,0.930507436281054,-0.088203334069224,-5.9358949235839,-0.0261601179217807,"TOR1AIP1","torsin 1A interacting protein 1",TRUE
+"1569676_at",0.7508466884305,0.243915316497344,1.19710983905352,-5.26479749286833,0.51023456884868,"TOR1AIP2","torsin 1A interacting protein 2",TRUE
+"235453_at",0.807084045192774,0.348430028399273,0.957939785797638,-5.50234914736414,0.411672415220258,"TOR1AIP2","torsin 1A interacting protein 2",TRUE
+"230241_at",0.865187396415238,0.494438812318435,0.694741650085349,-5.70729000514533,0.20942353766711,"TOR1AIP2","torsin 1A interacting protein 2",TRUE
+"231719_at",0.932415412515157,0.701984424439197,0.387635780927682,-5.86676047436453,0.12745559316097,"TOR1AIP2","torsin 1A interacting protein 2",TRUE
+"240700_at",0.947778780715578,0.7615276322465,0.307242980294232,-5.89380987442823,0.113965412771091,"TOR1AIP2","torsin 1A interacting protein 2",TRUE
+"214801_at",0.958366102520812,0.811600681827501,0.241222889502147,-5.91138169031285,0.105794301965364,"TOR1AIP2","torsin 1A interacting protein 2",TRUE
+"225880_at",0.998218866709129,0.991635279296052,0.0106027484851707,-5.93962872610028,0.00391985610286305,"TOR1AIP2","torsin 1A interacting protein 2",TRUE
+"230321_at",0.998982279127329,0.996723831700861,0.00415265659722468,-5.93967508156477,0.00209619969307351,"TOR1AIP2","torsin 1A interacting protein 2",TRUE
+"209593_s_at",0.729229845942426,0.21137328941007,-1.28701345956638,-5.16358890899031,-0.454064410689819,"TOR1B","torsin family 1 member B",TRUE
+"227972_at",0.39149295959037,0.0132685501279138,-2.69191343418603,-2.91792482311507,-1.56124074772659,"TOR2A","torsin family 2 member A",TRUE
+"244155_x_at",0.959888304606767,0.818630667681919,-0.232047877306341,-5.91349095163726,-0.109473886851133,"TOR2A","torsin family 2 member A",TRUE
+"233851_s_at",0.617775129514679,0.0884801911415045,-1.78188477907783,-4.50127940593324,-0.700004351253416,"TOR3A","torsin family 3 member A",TRUE
+"218459_at",0.710842845257879,0.184507295905221,-1.36968669695561,-5.06504237576033,-0.468664377293932,"TOR3A","torsin family 3 member A",TRUE
+"229708_at",0.663789119801086,0.131749584395535,1.56502073800351,-4.81232664004558,0.771360934058257,"TOR4A","torsin family 4 member A",TRUE
+"233589_x_at",0.877333806479767,0.527138415668346,0.642505036732737,-5.74059333958936,0.274429239500449,"TOR4A","torsin family 4 member A",TRUE
+"219620_x_at",0.951810226174863,0.779224736025076,0.283765643787861,-5.90053964912789,0.155750150896404,"TOR4A","torsin family 4 member A",TRUE
+"204530_s_at",0.75959865506602,0.257340212093095,1.16265346604658,-5.30190006328725,1.14547045687893,"TOX","thymocyte selection associated high mobility group box",TRUE
+"204529_s_at",0.79279559916191,0.324643496279046,1.00734634620286,-5.45716620507734,1.30970143571038,"TOX","thymocyte selection associated high mobility group box",TRUE
+"228737_at",0.457531863501901,0.0227649441624844,2.44754109524441,-3.37965975757561,4.41117283254154,"TOX2","TOX high mobility group box family member 2",TRUE
+"214774_x_at",0.411110107932987,0.0162564404549118,-2.60094932348184,-3.09234997508323,-6.50077088073109,"TOX3","TOX high mobility group box family member 3",TRUE
+"216623_x_at",0.466300647363886,0.0243832382407563,-2.41581353425927,-3.43792613869851,-5.76355994132212,"TOX3","TOX high mobility group box family member 3",TRUE
+"230745_s_at",0.485417260380271,0.0280818435223191,2.35004879690498,-3.5573588398355,1.60398266797691,"TOX3","TOX high mobility group box family member 3",TRUE
+"215108_x_at",0.591916637879047,0.0690542310197734,-1.91080566923886,-4.30243163185232,-4.65255760613184,"TOX3","TOX high mobility group box family member 3",TRUE
+"201685_s_at",0.208428274543958,0.00239290663914955,-3.42700914573791,-1.4249545637423,-1.00913718246149,"TOX4","TOX high mobility group box family member 4",TRUE
+"217448_s_at",0.630603891142543,0.101830714591069,-1.70683623043839,-4.61236358444967,-0.595394711842079,"TOX4","TOX high mobility group box family member 4",TRUE
+"201683_x_at",0.657015752622694,0.12529477576876,-1.59314474333929,-4.77373697716453,-0.589030650394474,"TOX4","TOX high mobility group box family member 4",TRUE
+"201684_s_at",0.689848451630875,0.158944993573203,-1.45772658857704,-4.9545172786145,-0.389403371950694,"TOX4","TOX high mobility group box family member 4",TRUE
+"232097_at",0.8877101263145,0.55274589738562,-0.602825070269386,-5.764218965853,-0.432379329315671,"TOX4","TOX high mobility group box family member 4",TRUE
+"201746_at",0.8920930097751,0.563476422839761,-0.586486986062165,-5.7735243378514,-0.633895212286083,"TP53","tumor protein p53",TRUE
+"211300_s_at",0.939976205834042,0.729985428273919,-0.349538551777543,-5.88035004381484,-0.413025409493272,"TP53","tumor protein p53",TRUE
+"220402_at",0.69826535129815,0.16917409133003,-1.42122449296504,-5.00102816211528,-1.11725702880285,"TP53AIP1","tumor protein p53 regulated apoptosis inducing protein 1",TRUE
+"223920_s_at",0.812302873476553,0.359475956613808,0.935777215577782,-5.52194206095055,0.663584054078269,"TP53AIP1","tumor protein p53 regulated apoptosis inducing protein 1",TRUE
+"223919_at",0.831661773968529,0.406332459707226,0.846484668104767,-5.59658424410439,0.334125883360414,"TP53AIP1","tumor protein p53 regulated apoptosis inducing protein 1",TRUE
+"220403_s_at",0.919691066792211,0.658546897555395,-0.447938379223435,-5.84242457770107,-0.309685563330778,"TP53AIP1","tumor protein p53 regulated apoptosis inducing protein 1",TRUE
+"1569097_at",0.67368843181164,0.140214253936466,-1.52981937961817,-4.8598637893949,-1.41244956969226,"TP53BP1","tumor protein p53 binding protein 1",TRUE
+"1569098_s_at",0.780557019982346,0.302043801952748,1.05667910238005,-5.41000135186802,0.667299863185572,"TP53BP1","tumor protein p53 binding protein 1",TRUE
+"203050_at",0.90466378569832,0.609025180528261,-0.518826618555543,-5.809418972958,-0.175176301124726,"TP53BP1","tumor protein p53 binding protein 1",TRUE
+"213266_at",0.981508003489034,0.912154378923716,-0.111588550819284,-5.93362038769277,-0.0394718951887967,"TP53BP1","tumor protein p53 binding protein 1",TRUE
+"203120_at",0.72993713735092,0.212285878756598,1.28435249068071,-5.16667454645566,0.619284210650694,"TP53BP2","tumor protein p53 binding protein 2",TRUE
+"214667_s_at",0.112518135066489,0.000584042994929543,-4.00856997061767,-0.182204113979926,-3.37262714123907,"TP53I11","tumor protein p53 inducible protein 11",TRUE
+"203421_at",0.183534093706442,0.00176687496438477,-3.55317745411973,-1.15815436656951,-2.98596014919839,"TP53I11","tumor protein p53 inducible protein 11",TRUE
+"216919_at",0.411431134161297,0.0163443698838287,2.59851815584183,-3.09697195843851,1.45522736317335,"TP53I11","tumor protein p53 inducible protein 11",TRUE
+"225605_at",0.917806614232276,0.650959174279435,0.458640948407252,-5.83774511366729,0.140846296734027,"TP53I13","tumor protein p53 inducible protein 13",TRUE
+"210609_s_at",0.989586772349659,0.94947286900422,0.0640905177144372,-5.93768302095479,0.0522419477913676,"TP53I3","tumor protein p53 inducible protein 3",TRUE
+"225912_at",0.296090407530139,0.00530659621668751,-3.09100750686029,-2.12289372538863,-1.89526915408367,"TP53INP1","tumor protein p53 inducible nuclear protein 1",TRUE
+"235602_at",0.558461161038969,0.0527256792552932,2.04675181617562,-4.08241449259905,1.2144449450168,"TP53INP1","tumor protein p53 inducible nuclear protein 1",TRUE
+"244721_at",0.930374550176682,0.692170472041412,-0.401124802671298,-5.86161690144165,-0.286049854674573,"TP53INP1","tumor protein p53 inducible nuclear protein 1",TRUE
+"224836_at",0.468735421183467,0.0250808835359752,-2.40273372543029,-3.4618256259927,-1.74988400026606,"TP53INP2","tumor protein p53 inducible nuclear protein 2",TRUE
+"235192_at",0.411110107932987,0.0161528779517392,-2.60382860758914,-3.08687331369118,-1.67822448629403,"TP53RK","TP53 regulating kinase",TRUE
+"225402_at",0.597654932724127,0.0741634304226298,-1.8741050248203,-4.36004131309948,-0.707692802765768,"TP53RK","TP53 regulating kinase",TRUE
+"210886_x_at",0.770807031642694,0.279265315147292,-1.10913635298014,-5.35763619393459,-0.602051322484146,"TP53TG1","TP53 target 1 (non-protein coding)",TRUE
+"209917_s_at",0.780553104302868,0.302028010509949,-1.05671447060636,-5.40996681033829,-0.818070246210498,"TP53TG1","TP53 target 1 (non-protein coding)",TRUE
+"210241_s_at",0.897011777275924,0.582685965750205,-0.557632626936797,-5.78935360407258,-0.375923866522442,"TP53TG1","TP53 target 1 (non-protein coding)",TRUE
+"220167_s_at",0.562001544457721,0.0548793094807457,2.02683921384684,-4.11527413825418,0.77915866269537,"TP53TG3B///TP53TG3D///TP53TG3C///TP53TG3","TP53 target 3B///TP53 target 3D///TP53 target 3C///TP53 target 3",TRUE
+"237730_at",0.798136642075741,0.332363512881216,0.991045779906713,-5.47230176693486,0.287706892680025,"TP53TG3HP","TP53 target 3 family member H, pseudogene",TRUE
+"232714_at",0.571677937624457,0.059457056898264,1.98672477199444,-4.18082100812842,1.46661917545101,"TP53TG5","TP53 target 5",TRUE
+"207482_at",0.784515251996446,0.307779646187906,1.04391839378221,-5.42239600267701,0.5807357982313,"TP53TG5","TP53 target 5",TRUE
+"211834_s_at",0.419667703001518,0.0173547083033641,2.57143050711655,-3.14832436503622,1.84868245296495,"TP63","tumor protein p63",TRUE
+"209863_s_at",0.581336273502073,0.0637714562712687,1.95135060927069,-4.23788813808131,1.93415741302116,"TP63","tumor protein p63",TRUE
+"1555581_a_at",0.593339168375633,0.0703532193153406,1.90125484033851,-4.31749890041034,1.40494937413042,"TP63","tumor protein p63",TRUE
+"211194_s_at",0.668620158511127,0.134924742556521,1.55160345539376,-4.83054654826052,2.03976706829528,"TP63","tumor protein p63",TRUE
+"211195_s_at",0.864511525588006,0.491811001223399,0.699022976063838,-5.70445018796652,0.519981108150206,"TP63","tumor protein p63",TRUE
+"207382_at",0.925511384407886,0.677794414451013,0.421022775311832,-5.85371344203473,0.375646917253889,"TP63","tumor protein p63",TRUE
+"211193_at",0.975196332002567,0.879478033135463,0.153391462267976,-5.92822989490924,0.0668412011245216,"TP63","tumor protein p63",TRUE
+"232546_at",0.654826820947014,0.123749831615168,1.60005447020715,-4.76417392783725,0.473142262431309,"TP73","tumor protein p73",TRUE
+"220804_s_at",0.791465219326274,0.321985566958835,1.01302075294394,-5.45184483091618,0.72079845899347,"TP73","tumor protein p73",TRUE
+"1554379_a_at",0.956398858120188,0.802535403963349,-0.253085661423476,-5.90853400622133,-0.218667163450352,"TP73","tumor protein p73",TRUE
+"1569502_s_at",0.739189560382301,0.226371639249578,1.24435566889612,-5.21239637397707,1.04629839677755,"TP73-AS1","TP73 antisense RNA 1",TRUE
+"213340_s_at",0.789503009592599,0.316611164911021,1.02459524662739,-5.44090662962224,0.929177010852955,"TP73-AS1","TP73 antisense RNA 1",TRUE
+"213339_at",0.981944022360435,0.913632425909207,0.10970305985521,-5.93382349167643,0.0907790195324871,"TP73-AS1","TP73 antisense RNA 1",TRUE
+"203476_at",0.812302873476553,0.358601878099595,0.937514098859629,-5.52042175783775,0.576710247054178,"TPBG","trophoblast glycoprotein",TRUE
+"239903_at",0.911393258378799,0.629532090544962,-0.489165332014678,-5.82380494256982,-0.391640809001259,"TPBG","trophoblast glycoprotein",TRUE
+"237393_at",0.843950128127185,0.440169094050953,0.78604160614778,-5.64314503459454,0.406632742576745,"TPBGL","trophoblast glycoprotein-like",TRUE
+"1557186_s_at",0.791592940931356,0.322095439540921,-1.01278554067499,-5.45206594718521,-0.713074315906577,"TPCN1","two pore segment channel 1",TRUE
+"217914_at",0.868100325087973,0.502100757903736,-0.682332098743923,-5.71542715746789,-0.228446574143241,"TPCN1","two pore segment channel 1",TRUE
+"1557185_at",0.92454958509576,0.673978469376528,0.426333266883358,-5.85154052803522,0.272756277726745,"TPCN1","two pore segment channel 1",TRUE
+"231978_at",0.701265550681908,0.172946770651941,1.40820883241622,-5.01737881800842,1.73004357048987,"TPCN2","two pore segment channel 2",TRUE
+"235194_at",0.723655063748891,0.200526272768483,1.31934430234167,-5.12566594444768,0.715960746480063,"TPCN2","two pore segment channel 2",TRUE
+"242554_at",0.851319596585235,0.454881639103395,0.760656375926991,-5.66173188129615,0.509271183156265,"TPCN2","two pore segment channel 2",TRUE
+"229250_at",0.929125618312698,0.688151523134705,0.406670530769267,-5.85945198085154,0.269445223690795,"TPCN2","two pore segment channel 2",TRUE
+"229251_s_at",0.99176128617116,0.96194182294542,0.0482594806571544,-5.93854918535396,0.0273065932032264,"TPCN2","two pore segment channel 2",TRUE
+"236655_at",0.68747436517451,0.15630873825175,1.46744042898551,-4.9419783535805,0.648519439031316,"TPD52","tumor protein D52",TRUE
+"201690_s_at",0.937113154905832,0.719656464519767,-0.36352748556846,-5.87552118065675,-0.134500588548137,"TPD52","tumor protein D52",TRUE
+"201689_s_at",0.961395512423249,0.82478078634782,-0.224037897798713,-5.91526585815159,-0.0781343164361967,"TPD52","tumor protein D52",TRUE
+"201691_s_at",0.975398143273847,0.881871710213244,-0.150320637771013,-5.92868364823626,-0.0686830849519335,"TPD52","tumor protein D52",TRUE
+"201688_s_at",0.99659046136788,0.982975474541056,-0.0215808604669557,-5.93945664165985,-0.00917700189949322,"TPD52","tumor protein D52",TRUE
+"210372_s_at",0.844169896707408,0.440741395813617,-0.785044564409039,-5.64388591427307,-0.690575341379834,"TPD52L1","tumor protein D52-like 1",TRUE
+"203786_s_at",0.91238586368984,0.633014270778617,-0.484173307304237,-5.82614481803083,-0.36540428446815,"TPD52L1","tumor protein D52-like 1",TRUE
+"201379_s_at",0.943464796017993,0.74681950987562,0.32688951064589,-5.88777109417454,0.11164629544508,"TPD52L2","tumor protein D52 like 2",TRUE
+"240051_at",0.709914655587487,0.182909332478481,1.37489521441267,-5.05866197733944,0.98825121005168,"TPD52L3","tumor protein D52 like 3",TRUE
+"231554_at",0.973071267819624,0.870324563435983,-0.165148569254801,-5.92640802101613,-0.0822125269286298,"TPD52L3","tumor protein D52 like 3",TRUE
+"227903_x_at",0.690850498237822,0.160560352649438,-1.45183867412841,-4.96208466003329,-0.969135374374622,"TPGS1","tubulin polyglutamylase complex subunit 1",TRUE
+"243600_at",0.85334340854827,0.461386240937655,0.749591380700976,-5.66965306545336,0.517853594125695,"TPGS1","tubulin polyglutamylase complex subunit 1",TRUE
+"235793_at",0.68747436517451,0.156276433861253,1.46756028169357,-4.94182322256748,0.713806017897987,"TPGS2","tubulin polyglutamylase complex subunit 2",TRUE
+"244233_at",0.805746717966166,0.345604369872207,0.963685452254201,-5.49720114697153,0.335911367435535,"TPGS2","tubulin polyglutamylase complex subunit 2",TRUE
+"236540_at",0.8288884913487,0.399502154587958,0.85906786878554,-5.58648595156692,0.339133931361327,"TPGS2","tubulin polyglutamylase complex subunit 2",TRUE
+"213617_s_at",0.87825462101175,0.530631241893044,-0.637032623728164,-5.743937774756,-0.246142036538192,"TPGS2","tubulin polyglutamylase complex subunit 2",TRUE
+"212055_at",0.904432955312383,0.608260315305252,-0.519941927463409,-5.8088619353652,-0.194051306689955,"TPGS2","tubulin polyglutamylase complex subunit 2",TRUE
+"239601_at",0.990627530017502,0.952796157677739,-0.0598696798996877,-5.93793781289185,-0.0173829581237444,"TPGS2","tubulin polyglutamylase complex subunit 2",TRUE
+"213616_at",0.998870448604467,0.995717920693127,-0.00542769512913523,-5.93966913194064,-0.00257575947733635,"TPGS2","tubulin polyglutamylase complex subunit 2",TRUE
+"1553859_at",0.689848451630875,0.158960438777873,1.45767006291308,-4.95459004593024,0.701194841684114,"TPH1","tryptophan hydroxylase 1",TRUE
+"214601_at",0.854219009487664,0.464900672823493,0.743651752895501,-5.67385976894871,0.578585057070575,"TPH1","tryptophan hydroxylase 1",TRUE
+"231626_at",0.947326616179611,0.760529574587798,0.308572162495508,-5.89341301239743,0.257432812539635,"TPH1","tryptophan hydroxylase 1",TRUE
+"1555332_at",0.976371465776674,0.887275714259343,0.14339328580915,-5.92967362624482,0.0767083131288526,"TPH2","tryptophan hydroxylase 2",TRUE
+"210050_at",0.914966942918905,0.641957876494049,-0.471408422422461,-5.83202124819597,-0.190538821067271,"TPI1","triosephosphate isomerase 1",TRUE
+"213011_s_at",0.919931255639931,0.659037987415128,0.447247532436127,-5.84272291278839,0.143131619094458,"TPI1","triosephosphate isomerase 1",TRUE
+"200822_x_at",0.936599157163462,0.717010765382172,0.367122472249788,-5.8742500037165,0.120944474566542,"TPI1","triosephosphate isomerase 1",TRUE
+"223686_at",0.51470556386048,0.0350764285288122,-2.24495382088538,-3.74427293754805,-1.85593232921193,"TPK1","thiamin pyrophosphokinase 1",TRUE
+"221218_s_at",0.801892820429336,0.339451313838221,-0.976308774107734,-5.48579219247048,-0.572485785585667,"TPK1","thiamin pyrophosphokinase 1",TRUE
+"238688_at",0.768170884271101,0.27130291547979,1.12820311495658,-5.33804469179083,0.710490043923063,"TPM1","tropomyosin 1 (alpha)",TRUE
+"1558532_at",0.782876787164404,0.305304048576487,-1.04940506481877,-5.41708330514417,-0.815406776109708,"TPM1","tropomyosin 1 (alpha)",TRUE
+"210986_s_at",0.841813886364358,0.434105535620147,-0.796654582807868,-5.63520391273148,-0.463179718350483,"TPM1","tropomyosin 1 (alpha)",TRUE
+"206116_s_at",0.916057757219214,0.645990359164957,-0.465679026461303,-5.83460886473245,-0.327878492531442,"TPM1","tropomyosin 1 (alpha)",TRUE
+"206117_at",0.925655603151125,0.678577086966625,0.41993508741351,-5.85415519213767,0.299474024435908,"TPM1","tropomyosin 1 (alpha)",TRUE
+"210987_x_at",0.934096381510989,0.708512318932642,-0.378703893514528,-5.87007091361872,-0.219761713951934,"TPM1","tropomyosin 1 (alpha)",TRUE
+"204083_s_at",0.462451365036068,0.0233361374693098,2.43611045044035,-3.40069919993811,4.92004672302217,"TPM2","tropomyosin 2 (beta)",TRUE
+"212654_at",0.594303508881191,0.071184768309553,1.89522170690767,-4.32698955219088,2.32504348379758,"TPM2","tropomyosin 2 (beta)",TRUE
+"229911_at",0.767011398042819,0.268719039379628,-1.1344783102963,-5.33153223848431,-0.720961785882348,"TPM2","tropomyosin 2 (beta)",TRUE
+"227397_at",0.923376218980614,0.671088599795267,-0.430363279448363,-5.84987369268149,-0.290307873534339,"TPM2","tropomyosin 2 (beta)",TRUE
+"238065_at",0.735165878294211,0.220193441663393,1.26165672041243,-5.19277084716248,0.510360657625935,"TPM3","tropomyosin 3",TRUE
+"238079_at",0.73957587762701,0.227854944334035,1.24025568126365,-5.21701308067587,0.938547144811614,"TPM3","tropomyosin 3",TRUE
+"214365_at",0.771153198056133,0.280012539913174,1.10736746493207,-5.35943875844906,0.556340588856918,"TPM3","tropomyosin 3",TRUE
+"224164_at",0.839519981963042,0.426954540212826,0.809289281910505,-5.62561952487746,0.288853038580957,"TPM3","tropomyosin 3",TRUE
+"222976_s_at",0.992583835836326,0.965423302048999,-0.0438417022647233,-5.93874734257349,-0.00996078048262028,"TPM3","tropomyosin 3",TRUE
+"1559989_at",0.64513208805899,0.115767004633012,1.6369505487569,-4.7125681162672,1.18375529562024,"TPM4","tropomyosin 4",TRUE
+"1567107_s_at",0.739340500562926,0.226670541485196,1.24352783277779,-5.21332959783406,1.06204563622991,"TPM4","tropomyosin 4",TRUE
+"212481_s_at",0.743474458360704,0.233781541742465,1.22407383873738,-5.2351060668113,0.981963707894415,"TPM4","tropomyosin 4",TRUE
+"209344_at",0.748237011093779,0.240739282040186,1.20546830184605,-5.25565492154328,1.10960913179856,"TPM4","tropomyosin 4",TRUE
+"235922_at",0.937504304897146,0.722960501563997,0.359044784470741,-5.87708894751666,0.22926130397783,"TPM4","tropomyosin 4",TRUE
+"238272_at",0.68806049531767,0.157479725464177,1.46310943203766,-4.94757727956184,0.825514238091315,"TPMT","thiopurine S-methyltransferase",TRUE
+"203672_x_at",0.779813064835198,0.301002597768177,1.0590139180351,-5.40771888470641,0.397272244187581,"TPMT","thiopurine S-methyltransferase",TRUE
+"203671_at",0.840775891914531,0.430083587472622,0.80374471063004,-5.62984295189213,0.444209799473821,"TPMT","thiopurine S-methyltransferase",TRUE
+"210342_s_at",0.992784989582189,0.965838616933996,0.0433147552097246,-5.93876970979584,0.0263950838818232,"TPO","thyroid peroxidase",TRUE
+"200743_s_at",0.954449231029359,0.790845353432177,0.268438443973169,-5.90464691963414,0.118453632487693,"TPP1","tripeptidyl peptidase 1",TRUE
+"200742_s_at",0.970740500720217,0.86062559289275,0.177632435382504,-5.9243267157336,0.0881771133486531,"TPP1","tripeptidyl peptidase 1",TRUE
+"214195_at",0.973071267819624,0.870006005861578,-0.165558157767485,-5.92634213336128,-0.0866081676003541,"TPP1","tripeptidyl peptidase 1",TRUE
+"214196_s_at",0.999016635322945,0.996852800761577,-0.00398918292862884,-5.93967572983377,-0.00194925076798391,"TPP1","tripeptidyl peptidase 1",TRUE
+"1569857_s_at",0.289452415034987,0.00497298689743604,3.11871078864351,-2.06618409319506,1.33837039188365,"TPP2","tripeptidyl peptidase 2",TRUE
+"203374_s_at",0.304824368772306,0.00602823695589637,3.03641617830415,-2.23413330968712,1.47815058151128,"TPP2","tripeptidyl peptidase 2",TRUE
+"203375_s_at",0.474859593446097,0.0260749246765068,2.38466648090748,-3.49472013842699,1.18306527336504,"TPP2","tripeptidyl peptidase 2",TRUE
+"1569856_at",0.932739823750021,0.702900736128292,-0.386380102258944,-5.86723046410202,-0.354433666418994,"TPP2","tripeptidyl peptidase 2",TRUE
+"230197_s_at",0.744726124993666,0.236279627251746,1.21734622522304,-5.24256782169418,0.988110029480214,"TPPP","tubulin polymerization promoting protein",TRUE
+"227643_at",0.879948283821082,0.534882064713776,-0.630398904991377,-5.7479550442111,-0.297659198919877,"TPPP","tubulin polymerization promoting protein",TRUE
+"206179_s_at",0.930827859648584,0.693811667573744,0.398863810587656,-5.86249114063815,0.26372801331059,"TPPP","tubulin polymerization promoting protein",TRUE
+"230104_s_at",0.973433731874338,0.871582176837464,0.163531862252096,-5.92666650009183,0.121242889464138,"TPPP","tubulin polymerization promoting protein",TRUE
+"231140_at",0.420127229072219,0.0174198157897891,2.569736039385,-3.15152779974916,1.53094022268224,"TPPP2","tubulin polymerization promoting protein family member 2",TRUE
+"1559785_at",0.792344934473527,0.323489725586755,1.00980553820889,-5.45486333555316,0.574949225982543,"TPPP2","tubulin polymerization promoting protein family member 2",TRUE
+"218876_at",0.892282308639655,0.564532777694796,0.58488734833335,-5.77442212593822,0.328482246073663,"TPPP3","tubulin polymerization promoting protein family member 3",TRUE
+"1557227_s_at",0.547343369043481,0.0477407510040659,2.09578800816521,-4.00060271410404,0.741752951378917,"TPR","translocated promoter region, nuclear basket protein",TRUE
+"215220_s_at",0.548924465506383,0.0485553514624537,2.08747027397092,-4.01456830458246,0.728086566144997,"TPR","translocated promoter region, nuclear basket protein",TRUE
+"201731_s_at",0.579036829255831,0.061929004550263,1.96618986565663,-4.2140335713763,0.50305444664493,"TPR","translocated promoter region, nuclear basket protein",TRUE
+"201730_s_at",0.690015152288705,0.159704145802251,1.4549535175991,-4.9580844404222,0.478064770653218,"TPR","translocated promoter region, nuclear basket protein",TRUE
+"228709_at",0.932091525948902,0.700318599909953,0.389920191368284,-5.86590158504355,0.144877255720503,"TPR","translocated promoter region, nuclear basket protein",TRUE
+"218855_at",0.6708432030569,0.136764997685344,1.54394605098831,-4.84088936520663,0.361327426974093,"TPRA1","transmembrane protein adipocyte associated 1",TRUE
+"229764_at",0.943400587031071,0.746026063260668,-0.327953034974222,-5.88743362774006,-0.558297788045684,"TPRG1","tumor protein p63 regulated 1",TRUE
+"224871_at",0.737123149977386,0.223069681964652,1.25355670529227,-5.20198808215375,0.439684302615827,"TPRG1L","tumor protein p63 regulated 1-like",TRUE
+"219030_at",0.822469863206885,0.387429888251127,0.881651516942099,-5.56801462862931,0.265598532914646,"TPRKB","TP53RK binding protein",TRUE
+"225891_at",0.525405708458677,0.0393242864706766,-2.1901427289816,-3.8397275223284,-1.04393776172113,"TPRN","taperin",TRUE
+"239061_at",0.606103871227474,0.0796084868626919,1.83734659624861,-4.41694984490861,1.4374354664631,"TPRXL","tetrapeptide repeat homeobox like",TRUE
+"205683_x_at",0.673322568613087,0.138988121087588,-1.53480798768561,-4.85317907546588,-0.988179925952521,"TPSAB1","tryptase alpha/beta 1",TRUE
+"207741_x_at",0.732963666545614,0.217277437783427,-1.26995195445301,-5.18327880859826,-0.738337043875933,"TPSAB1","tryptase alpha/beta 1",TRUE
+"216485_s_at",0.818179047799488,0.371162229950996,0.912822137026502,-5.54179099596532,0.308162245678549,"TPSAB1","tryptase alpha/beta 1",TRUE
+"215382_x_at",0.844735153180923,0.441672497923787,0.783424128191132,-5.64508813451359,0.473313578744092,"TPSAB1","tryptase alpha/beta 1",TRUE
+"210084_x_at",0.913627134030439,0.637970888527911,-0.477088964501815,-5.82942512471185,-0.302925906544779,"TPSAB1","tryptase alpha/beta 1",TRUE
+"207134_x_at",0.773754791548713,0.285357231553357,1.09481388315528,-5.37215787442713,0.686449918449003,"TPSB2","tryptase beta 2 (gene/pseudogene)",TRUE
+"217023_x_at",0.841526980254885,0.432623320619994,0.799262768683634,-5.63323701236882,0.503166261591349,"TPSB2///TPSAB1","tryptase beta 2 (gene/pseudogene)///tryptase alpha/beta 1",TRUE
+"216474_x_at",0.858711967211834,0.474506867165765,0.727551236667244,-5.68510316659553,0.462702935246232,"TPSB2///TPSAB1","tryptase beta 2 (gene/pseudogene)///tryptase alpha/beta 1",TRUE
+"214568_at",0.822812833182588,0.387913976274125,-0.88073721244001,-5.56877108768294,-0.276307702763771,"TPSD1","tryptase delta 1",TRUE
+"220339_s_at",0.968066640321622,0.849713233872102,-0.191712823465666,-5.92179789521763,-0.133864886918457,"TPSG1","tryptase gamma 1",TRUE
+"204140_at",0.582527497755585,0.0643599006697487,1.94669094583007,-4.2453532237217,1.06580879524484,"TPST1","tyrosylprotein sulfotransferase 1",TRUE
+"204079_at",0.899798994481376,0.591667887641701,0.544304901820658,-5.79640351278371,0.410666945812949,"TPST2","tyrosylprotein sulfotransferase 2",TRUE
+"227709_at",0.466588527879849,0.0244238933112415,2.41504186894536,-3.43933810662539,0.789521784523089,"TPT1-AS1","TPT1 antisense RNA 1",TRUE
+"226407_at",0.528542240343523,0.0411404001104247,2.16833548175486,-3.87730266169057,1.63806100767691,"TPT1-AS1","TPT1 antisense RNA 1",TRUE
+"228913_at",0.550213045400235,0.0487468128380199,2.085533481493,-4.01781506788747,1.15095697011105,"TPT1-AS1","TPT1 antisense RNA 1",TRUE
+"227710_s_at",0.954387719376857,0.790256744905889,-0.269213189867113,-5.90444474108419,-0.254231749202268,"TPT1-AS1","TPT1 antisense RNA 1",TRUE
+"1563983_at",0.980025041090473,0.906277610653817,-0.11908950174309,-5.93277816066867,-0.0851593896373766,"TPT1-AS1","TPT1 antisense RNA 1",TRUE
+"208588_at",0.960138290470901,0.819583908986142,0.230805362273647,-5.91377034132032,0.0707434310183404,"TPT1P8","tumor protein, translationally-controlled 1 pseudogene 8",TRUE
+"220205_at",0.918649061425129,0.654236070485078,0.45401224839929,-5.83978220371484,0.593284601529157,"TPTE","transmembrane phosphatase with tensin homology",TRUE
+"240409_at",0.765889357241662,0.266077866023465,1.14093859285926,-5.32479441514524,0.37630298656427,"TPTE2P5","transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5",TRUE
+"236770_at",0.781196073006007,0.302900234415713,1.05476290958266,-5.41187120480204,0.5148183452712,"TPTE2P5","transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5",TRUE
+"233675_s_at",0.943988850936011,0.749371307934775,-0.323471716309228,-5.88884824681412,-0.289571699206815,"TPTE2P6","transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6",TRUE
+"243952_at",0.619015527816291,0.0893850496956491,1.77650151116159,-4.50936463896588,1.42607892874761,"TPTEP1","transmembrane phosphatase with tensin homology pseudogene 1",TRUE
+"233469_at",0.720952283360079,0.196900909665732,1.3304536598609,-5.11245166696445,0.524628276838682,"TPTEP1","transmembrane phosphatase with tensin homology pseudogene 1",TRUE
+"210052_s_at",0.463632028061434,0.023776132450369,2.42748086575793,-3.41654760399761,0.755510254929082,"TPX2","TPX2, microtubule nucleation factor",TRUE
+"229574_at",0.635916735157933,0.107189138665339,1.67906084594448,-4.65256912448189,0.766934167782532,"TRA2A","transformer 2 alpha homolog",TRUE
+"227939_s_at",0.730101539866086,0.212904057869372,1.28255498987644,-5.16875583649649,0.94569265070802,"TRA2A","transformer 2 alpha homolog",TRUE
+"213575_at",0.774447611376107,0.290841020656344,1.08210895498649,-5.38489883900524,0.834343301595402,"TRA2A","transformer 2 alpha homolog",TRUE
+"213593_s_at",0.816358096928248,0.367381399641153,0.920195310202671,-5.53546500252454,0.740689787360852,"TRA2A","transformer 2 alpha homolog",TRUE
+"204658_at",0.996917497388089,0.984277660503678,-0.0199299278932,-5.93949002013881,-0.00643614690019056,"TRA2A","transformer 2 alpha homolog",TRUE
+"200893_at",0.752235383514782,0.245553473944312,-1.19283056523804,-5.26945679218123,-0.249104778938291,"TRA2B","transformer 2 beta homolog (Drosophila)",TRUE
+"239447_at",0.89205696974366,0.56247029758967,0.588011998473041,-5.7726662243944,0.479858517199243,"TRA2B","transformer 2 beta homolog (Drosophila)",TRUE
+"200892_s_at",0.957440336789825,0.808073187090327,-0.245834649501297,-5.91029077198476,-0.056165746736994,"TRA2B","transformer 2 beta homolog (Drosophila)",TRUE
+"210180_s_at",0.969882914559333,0.85713189218996,-0.182136274616865,-5.92353873692482,-0.0560096849043976,"TRA2B","transformer 2 beta homolog (Drosophila)",TRUE
+"232706_s_at",0.861596375509409,0.482207408413546,0.714782485777974,-5.69385361486984,0.481749439451873,"TRABD","TraB domain containing",TRUE
+"221807_s_at",0.863230457544525,0.487297892509935,0.70640665485036,-5.6995134853199,0.320680994873605,"TRABD","TraB domain containing",TRUE
+"225360_at",0.96350209729653,0.833396991464379,0.212841092450285,-5.91764292877231,0.0795474017916025,"TRABD","TraB domain containing",TRUE
+"231429_at",0.585036027492332,0.0655286796486035,1.93754617188314,-4.25996817050418,1.37307324104096,"TRABD2A","TraB domain containing 2A",TRUE
+"227867_at",0.820536502908875,0.380553913722593,0.894719626860624,-5.55712312347883,0.318225293770601,"TRABD2A","TraB domain containing 2A",TRUE
+"230920_at",0.683019114815084,0.151986916860684,-1.4836564514709,-4.92089619888891,-0.556013647786471,"TRABD2B","TraB domain containing 2B",TRUE
+"241707_at",0.784124594631274,0.307194377411671,1.04521269765835,-5.42114499606155,0.654673058452159,"TRABD2B","TraB domain containing 2B",TRUE
+"244472_at",0.99574737652189,0.979556806467424,0.0259154082287754,-5.93935637036164,0.0124525468452821,"TRABD2B","TraB domain containing 2B",TRUE
+"209671_x_at",0.896599256925387,0.581343954332805,0.559632692875767,-5.78828135348742,0.278522571925736,"TRAC","T-cell receptor alpha constant",TRUE
+"209670_at",0.957571530817866,0.809536613663337,0.243920745863065,-5.91074600201411,0.203535834450081,"TRAC","T-cell receptor alpha constant",TRUE
+"210972_x_at",0.954672574687803,0.79346777708121,-0.26498875537388,-5.90554012931645,-0.124095180780471,"TRAC///TRAJ17///TRAV20///TRDV2","T-cell receptor alpha constant///T cell receptor alpha joining 17///T cell receptor alpha variable 20///T cell receptor delta variable 2",TRUE
+"1729_at",0.840041055449124,0.428978051626525,0.80570081091486,-5.62835605817481,0.333960087017642,"TRADD","TNFRSF1A associated via death domain",TRUE
+"205641_s_at",0.965301182639184,0.838271607713003,-0.206518900353391,-5.91893153513662,-0.0676528657353526,"TRADD","TNFRSF1A associated via death domain",TRUE
+"213443_at",0.975398143273847,0.880811805240837,-0.15168019494707,-5.92848388580879,-0.0888193522734309,"TRADD","TNFRSF1A associated via death domain",TRUE
+"205599_at",0.766550448794594,0.267307376992149,1.1379253875939,-5.32794126857704,0.513747766239301,"TRAF1","TNF receptor associated factor 1",TRUE
+"235116_at",0.768852835478002,0.273435844478175,1.12305597812892,-5.34336260487295,0.427962188127321,"TRAF1","TNF receptor associated factor 1",TRUE
+"204413_at",0.979347742195592,0.900250862429891,-0.126789162602065,-5.93185673329057,-0.0503238307679776,"TRAF2","TNF receptor associated factor 2",TRUE
+"221571_at",0.729083413548563,0.210991601915009,1.28812903383396,-5.16229368185236,0.486670514592369,"TRAF3","TNF receptor associated factor 3",TRUE
+"208315_x_at",0.956462414390747,0.80276813696036,-0.252780651075204,-5.90860892630193,-0.0672682669433389,"TRAF3","TNF receptor associated factor 3",TRUE
+"238494_at",0.749093407333923,0.242203443161392,-1.20160479158476,-5.25988773767854,-0.406067286097176,"TRAF3IP1","TRAF3 interacting protein 1",TRUE
+"214458_at",0.88113080359582,0.537179559412036,0.626825337656895,-5.75010236482133,0.293712946262505,"TRAF3IP1","TRAF3 interacting protein 1",TRUE
+"215411_s_at",0.864079461576774,0.490981438910671,-0.700377251186316,-5.70354842818085,-0.329067816426159,"TRAF3IP2","TRAF3 interacting protein 2",TRUE
+"202987_at",0.932091525948902,0.700540343190536,0.389615984493711,-5.86601624735632,0.182655851977625,"TRAF3IP2","TRAF3 interacting protein 2",TRUE
+"1562566_at",0.755049574909504,0.24899476904774,1.1839102330149,-5.27912256614057,0.949451222245178,"TRAF3IP2-AS1","TRAF3IP2 antisense RNA 1",TRUE
+"236555_at",0.797334932908547,0.330476331478157,0.995006082462351,-5.468645126888,0.434862594880433,"TRAF3IP2-AS1","TRAF3IP2 antisense RNA 1",TRUE
+"230589_at",0.815100643136321,0.365998842746706,0.922904102997269,-5.53312915105529,0.453545087652382,"TRAF3IP2-AS1","TRAF3IP2 antisense RNA 1",TRUE
+"240577_at",0.886783047600321,0.550036980885571,0.606975731390507,-5.76181562247448,0.346388680111473,"TRAF3IP2-AS1","TRAF3IP2 antisense RNA 1",TRUE
+"243553_x_at",0.896159990898752,0.579237120900666,0.562777275399637,-5.78658798827102,0.301017073189568,"TRAF3IP2-AS1","TRAF3IP2 antisense RNA 1",TRUE
+"215275_at",0.742608239479028,0.232867275095893,1.22654966390736,-5.2323511240233,0.751186959325449,"TRAF3IP3","TRAF3 interacting protein 3",TRUE
+"213888_s_at",0.884749233889577,0.544310649680614,-0.615785370870467,-5.7566618921367,-0.619889386923276,"TRAF3IP3","TRAF3 interacting protein 3",TRUE
+"240265_at",0.915742010892393,0.644542903818513,-0.467733757263459,-5.83368443177416,-0.372696042548864,"TRAF3IP3","TRAF3 interacting protein 3",TRUE
+"205804_s_at",0.928295253101366,0.685243971342247,-0.410690741700461,-5.85786429622118,-0.350390786894585,"TRAF3IP3","TRAF3 interacting protein 3",TRUE
+"242473_at",0.728262401376535,0.208525206024876,1.29537554937916,-5.1538569643185,0.419907488882584,"TRAF4","TNF receptor associated factor 4",TRUE
+"235688_s_at",0.914777625972484,0.641153625826629,0.472553022286287,-5.83150059081506,0.16514371924081,"TRAF4","TNF receptor associated factor 4",TRUE
+"211899_s_at",0.921312278448293,0.664695194903459,-0.439305003742634,-5.8461203553822,-0.142153251075495,"TRAF4","TNF receptor associated factor 4",TRUE
+"202871_at",0.968451827985008,0.851742688454911,0.189091269698406,-5.92228328129133,0.062042768850386,"TRAF4","TNF receptor associated factor 4",TRUE
+"204352_at",0.985498770484702,0.929822147413622,-0.0890755318995186,-5.93581964130112,-0.09286128534964,"TRAF5","TNF receptor associated factor 5",TRUE
+"1569861_at",0.998347572104896,0.992891318725403,0.00901059967340114,-5.9396439357294,0.00484815783957693,"TRAF5","TNF receptor associated factor 5",TRUE
+"205558_at",0.829044392052913,0.400200894641535,0.857774304111146,-5.5875304670744,0.276505435484101,"TRAF6","TNF receptor associated factor 6",TRUE
+"227264_at",0.88113080359582,0.537204796638809,-0.626786128881687,-5.7501258598058,-0.264815286425991,"TRAF6","TNF receptor associated factor 6",TRUE
+"223031_s_at",0.894729774938685,0.571543503610648,-0.574309674621913,-5.78029904588342,-0.20718236955357,"TRAF7","TNF receptor associated factor 7",TRUE
+"223030_at",0.931501755169233,0.69707577618547,-0.394373280746885,-5.86421302453515,-0.203485724859427,"TRAF7","TNF receptor associated factor 7",TRUE
+"223029_s_at",0.953931868692178,0.787519391991931,-0.272818404864989,-5.90349630982378,-0.0790501645637143,"TRAF7","TNF receptor associated factor 7",TRUE
+"242497_at",0.703181475205533,0.175014056051155,-1.40117273372706,-5.02616618037776,-0.532812673020513,"TRAFD1","TRAF-type zinc finger domain containing 1",TRUE
+"243196_s_at",0.91704891241952,0.648857517944977,0.461614949193959,-5.83642557267697,0.142622736885192,"TRAFD1","TRAF-type zinc finger domain containing 1",TRUE
+"202837_at",0.92346045063848,0.67153323725775,0.429742748655591,-5.85013135108006,0.317975469580571,"TRAFD1","TRAF-type zinc finger domain containing 1",TRUE
+"35254_at",0.954723352940649,0.794048867640017,0.264224800992588,-5.9057363840676,0.0821271425893322,"TRAFD1","TRAF-type zinc finger domain containing 1",TRUE
+"205598_at",0.955892698633978,0.800109386588431,-0.256266567912983,-5.90774732552322,-0.111971172904496,"TRAIP","TRAF interacting protein",TRUE
+"214924_s_at",0.620912785033482,0.09099843585551,1.76701825932183,-4.5235641407703,0.615085046615871,"TRAK1","trafficking kinesin protein 1",TRUE
+"226013_at",0.709914655587487,0.182878007006905,1.37499767835979,-5.05853625772963,0.486159495014043,"TRAK1","trafficking kinesin protein 1",TRUE
+"202079_s_at",0.765894215161172,0.266126352073744,1.14081957268949,-5.32491885346615,0.430622159359951,"TRAK1","trafficking kinesin protein 1",TRUE
+"202080_s_at",0.782257848574678,0.304306853467292,1.05162405890659,-5.41492756429499,0.616254139490263,"TRAK1","trafficking kinesin protein 1",TRUE
+"201283_s_at",0.872668627020452,0.516105855140037,0.659921986630745,-5.72976626652907,0.400729302143165,"TRAK1","trafficking kinesin protein 1",TRUE
+"202124_s_at",0.952082954955992,0.780891366022981,-0.281563234099819,-5.90114375748104,-0.142728892026057,"TRAK2","trafficking kinesin protein 2",TRUE
+"202125_s_at",0.978276691813018,0.895487734281809,-0.132879981278206,-5.9310870211377,-0.0459117393354322,"TRAK2","trafficking kinesin protein 2",TRUE
+"210733_at",0.897011777275924,0.582610528651281,0.557744993533601,-5.7892934622477,0.175874295847715,"TRAM1","translocation associated membrane protein 1",TRUE
+"201398_s_at",0.9286288141895,0.686296633402067,-0.4092344562044,-5.85844119598436,-0.142337556474562,"TRAM1","translocation associated membrane protein 1",TRUE
+"201399_s_at",0.978999293602992,0.898488841242498,-0.129041750577091,-5.93157626896774,-0.0464554650561801,"TRAM1","translocation associated membrane protein 1",TRUE
+"244334_at",0.953564723226096,0.786266435296466,-0.274469834453082,-5.90305768172704,-0.160724812637382,"TRAM1L1","translocation associated membrane protein 1-like 1",TRUE
+"1554383_a_at",0.83030603167465,0.402225930756475,0.854033564923573,-5.59054275416967,0.811562410516041,"TRAM2","translocation associated membrane protein 2",TRUE
+"202368_s_at",0.872289159593181,0.515360492802839,0.661106053534193,-5.72902011924784,0.368138532412965,"TRAM2","translocation associated membrane protein 2",TRUE
+"202369_s_at",0.890553592605148,0.55928557310074,0.592848490349888,-5.7699305124807,0.311986141595028,"TRAM2","translocation associated membrane protein 2",TRUE
+"227298_at",0.994701128358967,0.975467640124581,0.0311007601379539,-5.93921237637126,0.00877691074038722,"TRAM2-AS1","TRAM2 antisense RNA 1 (head to head)",TRUE
+"213261_at",0.775341201891078,0.29190631587355,1.07966090554471,-5.38733858800756,0.398238964212513,"TRANK1","tetratricopeptide repeat and ankyrin repeat containing 1",TRUE
+"201391_at",0.697412165374288,0.167863352044892,-1.42580094746633,-4.99524974320555,-0.557032766649249,"TRAP1","TNF receptor associated protein 1",TRUE
+"239622_at",0.854593182713431,0.466202883388028,0.741457714590413,-5.67540565980491,0.569712098582972,"TRAP1","TNF receptor associated protein 1",TRUE
+"225294_s_at",0.939356991756184,0.728431566545811,0.351638403001535,-5.87963713299574,0.143060197390147,"TRAPPC1","trafficking protein particle complex 1",TRUE
+"1555446_s_at",0.621591875129701,0.0919626278541226,1.76141963598579,-4.53192090445968,0.577822719131468,"TRAPPC10","trafficking protein particle complex 10",TRUE
+"215269_at",0.812302873476553,0.358039136056822,0.938633830794659,-5.51944027809032,0.354888115629659,"TRAPPC10","trafficking protein particle complex 10",TRUE
+"234747_at",0.729083413548563,0.211132227156664,1.28771784115419,-5.1627712043751,1.03920838997104,"TRAPPC11","trafficking protein particle complex 11",TRUE
+"218179_s_at",0.755049574909504,0.248704419554253,-1.18465928559472,-5.27831335082031,-0.522504511603305,"TRAPPC11","trafficking protein particle complex 11",TRUE
+"233558_s_at",0.776983560547865,0.29597412164436,-1.0703716321838,-5.39655144512337,-0.469633875349592,"TRAPPC11","trafficking protein particle complex 11",TRUE
+"203122_at",0.683838837468118,0.152769873994279,-1.48069115102334,-4.92476530446199,-0.769017701920964,"TRAPPC12","trafficking protein particle complex 12",TRUE
+"1556449_at",0.725583196024696,0.204411665154057,-1.30761070093733,-5.13952115650885,-0.826322037558499,"TRAPPC12","trafficking protein particle complex 12",TRUE
+"1559369_at",0.122625587810579,0.000690785204310163,-3.93987949913332,-0.330284931588441,-1.95137457106207,"TRAPPC13","trafficking protein particle complex 13",TRUE
+"236526_x_at",0.425751189365875,0.0181714823308458,-2.55059135552546,-3.18764744542269,-1.06318383842873,"TRAPPC13","trafficking protein particle complex 13",TRUE
+"218674_at",0.680160698079016,0.147427241571731,-1.50117689199041,-4.89790861597786,-0.679877154994939,"TRAPPC13","trafficking protein particle complex 13",TRUE
+"219351_at",0.456390294234872,0.0222623304019095,-2.45782163854228,-3.36069196589685,-0.708882412679136,"TRAPPC2","trafficking protein particle complex 2",TRUE
+"1562349_at",0.835083899263907,0.41393084463595,-0.832644000925433,-5.60753103470927,-0.347411961572394,"TRAPPC2","trafficking protein particle complex 2",TRUE
+"209751_s_at",0.947778780715578,0.761486223162046,-0.307298116379271,-5.89379344586039,-0.0985224878043454,"TRAPPC2B///TRAPPC2","trafficking protein particle complex 2B///trafficking protein particle complex 2",TRUE
+"238627_at",0.467361806748287,0.0245009923879428,-2.41358172708814,-3.44200914970475,-1.25162539204016,"TRAPPC2L","trafficking protein particle complex 2 like",TRUE
+"238628_s_at",0.585036027492332,0.0655772539631541,-1.93716923581907,-4.26056956592727,-1.03458669701159,"TRAPPC2L","trafficking protein particle complex 2 like",TRUE
+"218354_at",0.718706241731185,0.194456565586948,-1.33803461083346,-5.1033808378617,-0.556823231266339,"TRAPPC2L","trafficking protein particle complex 2 like",TRUE
+"203511_s_at",0.831875452294783,0.407609679810554,-0.844146737247916,-5.5984451756114,-0.220468707082452,"TRAPPC3","trafficking protein particle complex 3",TRUE
+"203512_at",0.931370027472813,0.6955245948602,-0.396506251540739,-5.86339753572779,-0.111858613232824,"TRAPPC3","trafficking protein particle complex 3",TRUE
+"232368_at",0.904381089098038,0.607340166384907,0.521284553157127,-5.80818981934277,0.228049168982035,"TRAPPC3L","trafficking protein particle complex 3 like",TRUE
+"225870_s_at",0.869971289491322,0.507835423249341,-0.673114014972104,-5.72138084014466,-0.235511222411352,"TRAPPC5","trafficking protein particle complex 5",TRUE
+"204985_s_at",0.724970327905974,0.202894862265906,-1.3121704991792,-5.13414930510851,-1.13819607210726,"TRAPPC6A","trafficking protein particle complex 6A",TRUE
+"225537_at",0.581852599439475,0.0641234053711392,-1.94855912552873,-4.2423617443687,-0.676018735109768,"TRAPPC6B","trafficking protein particle complex 6B",TRUE
+"207305_s_at",0.546044624961573,0.0472889126509931,-2.10045674330449,-3.99274820655047,-0.684019035877663,"TRAPPC8","trafficking protein particle complex 8",TRUE
+"221836_s_at",0.900250794823241,0.595081576901326,0.539265700974202,-5.79902590461866,0.216741491469511,"TRAPPC9","trafficking protein particle complex 9",TRUE
+"56829_at",0.921006039723366,0.663894565993315,-0.440427305217044,-5.84564391147824,-0.165708816442969,"TRAPPC9","trafficking protein particle complex 9",TRUE
+"230039_at",0.954456115752166,0.791143687044086,0.268045831582959,-5.90474915528515,0.149113959310302,"TRAPPC9","trafficking protein particle complex 9",TRUE
+"221672_s_at",0.990810941805126,0.956009094968149,-0.0557900572368271,-5.93816759561162,-0.0557909848888061,"TRAPPC9","trafficking protein particle complex 9",TRUE
+"217147_s_at",0.957430653957785,0.807388717611059,-0.246730136575766,-5.91007656190773,-0.164997918023804,"TRAT1","T cell receptor associated transmembrane adaptor 1",TRUE
+"211667_x_at",0.998870448604467,0.995696757931122,-0.00545451999613553,-5.9396689897603,-0.0045933259055122,"TRAV12-2","T cell receptor alpha variable 12-2",TRUE
+"215797_at",0.871451481476429,0.512622192841362,-0.665464245752121,-5.72626273394528,-0.259462565213713,"TRAV8-3","T cell receptor alpha variable 8-3",TRUE
+"213193_x_at",0.407748633394319,0.0156068926693414,2.61930092846269,-3.05739282055049,1.41886886068442,"TRBC1","T cell receptor beta constant 1",TRUE
+"210915_x_at",0.468735421183467,0.0250670398318334,2.40298998382841,-3.46135807567849,1.8244443131424,"TRBC1","T cell receptor beta constant 1",TRUE
+"211796_s_at",0.559434208511607,0.0540351541865532,2.03455985094524,-4.10255875130689,3.02151978494488,"TRBC1","T cell receptor beta constant 1",TRUE
+"217060_at",0.922635094827638,0.669208139835982,0.432989530975954,-5.84877917064033,0.260194068990184,"TRBV16","T cell receptor beta variable 16 (gene/pseudogene)",TRUE
+"241133_at",0.658033341494832,0.12656385220228,-1.58752171792601,-4.78149543360622,-1.13063564665945,"TRBV27","T cell receptor beta variable 27",TRUE
+"206308_at",0.736484292896758,0.222026057065817,1.25648644924591,-5.19866011863469,0.626212048726282,"TRDMT1","tRNA aspartic acid methyltransferase 1",TRUE
+"232121_at",0.801086839730802,0.337131631320338,-0.98110838216224,-5.48141878490773,-0.409125153208687,"TRDMT1","tRNA aspartic acid methyltransferase 1",TRUE
+"243504_at",0.986280972175967,0.932867566440018,-0.0852000227577435,-5.93614848649656,-0.0414867962252039,"TRDMT1","tRNA aspartic acid methyltransferase 1",TRUE
+"222287_at",0.466300647363886,0.0243632051379058,2.41619421645782,-3.43722948784153,1.68880337832311,"TRDN","triadin",TRUE
+"1552791_a_at",0.756313947022433,0.251593844656665,1.17723393909728,-5.28631534870864,1.33825620596425,"TRDN","triadin",TRUE
+"222919_at",0.78187900363728,0.303431341855154,1.05357653674878,-5.41302736032106,0.992331544848143,"TRDN","triadin",TRUE
+"234440_at",0.925819519240262,0.678849648401319,0.419556427002291,-5.85430871644436,0.149529001290444,"TRDV3","T cell receptor delta variable 3",TRUE
+"216191_s_at",0.974451535839172,0.875083345896903,-0.159033319198303,-5.92737237918299,-0.16921076778641,"TRDV3","T cell receptor delta variable 3",TRUE
+"207378_at",0.979338556459996,0.90013169598142,0.126941485032771,-5.93183792344398,0.0663026594351672,"TREH","trehalase",TRUE
+"219434_at",0.528328646587879,0.0409681158086704,2.17036637067785,-3.87381315939994,1.41593727850747,"TREM1","triggering receptor expressed on myeloid cells 1",TRUE
+"219725_at",0.564871506080311,0.0560997215915152,2.01586227904291,-4.13329724270671,0.893752626345011,"TREM2","triggering receptor expressed on myeloid cells 2",TRUE
+"1555659_a_at",0.755940660414394,0.250642506157879,-1.17967166214933,-5.28369315639289,-0.658423448661111,"TREML1","triggering receptor expressed on myeloid cells like 1",TRUE
+"219748_at",0.974982245454858,0.877663658752357,0.155720110061348,-5.92787970427714,0.0617516688040456,"TREML2","triggering receptor expressed on myeloid cells like 2",TRUE
+"1557446_x_at",0.726854823083796,0.207028992407571,1.29980397733223,-5.14868141181084,1.24327246306206,"TREML3P","triggering receptor expressed on myeloid cells like 3, pseudogene",TRUE
+"1557444_at",0.996261754016157,0.981618417206058,-0.0233014253471085,-5.93941903015417,-0.0170730466223739,"TREML3P","triggering receptor expressed on myeloid cells like 3, pseudogene",TRUE
+"1564052_at",0.673366993714442,0.13922398093684,1.53384557110694,-4.8544700547183,0.487540721928373,"TREML4","triggering receptor expressed on myeloid cells like 4",TRUE
+"1567558_at",0.7768734672127,0.294952546790476,1.07269586380733,-5.39425300922854,0.256079604405516,"TREML4","triggering receptor expressed on myeloid cells like 4",TRUE
+"1567559_s_at",0.806221445484273,0.347040177768127,-0.960761917668198,-5.49982409204807,-0.689745094480082,"TREML4","triggering receptor expressed on myeloid cells like 4",TRUE
+"1567624_at",0.861962516141708,0.484571711804002,0.710885947849432,-5.69649455826982,0.40708731857283,"TREML5P","triggering receptor expressed on myeloid cells like 5, pseudogene",TRUE
+"229016_s_at",0.953564723226096,0.7862435528742,0.274500001318652,-5.90304964481273,0.163046134188186,"TRERF1","transcriptional regulating factor 1",TRUE
+"233324_at",0.965254312438407,0.838107324634449,0.206731827647632,-5.9188887653258,0.177675302579481,"TRERF1","transcriptional regulating factor 1",TRUE
+"238520_at",0.986889306520757,0.93899692941097,-0.0774039677419553,-5.93676572454185,-0.0618478759020586,"TRERF1","transcriptional regulating factor 1",TRUE
+"239237_at",0.834950917495714,0.413730567931086,0.833006732943384,-5.6072462965339,0.582430505397816,"TRG-AS1","T cell receptor gamma locus antisense RNA 1",TRUE
+"206622_at",0.874022755316011,0.519857704670812,-0.653976202796155,-5.73349364488945,-0.684523667145218,"TRH","thyrotropin releasing hormone",TRUE
+"219937_at",0.0882335969288067,0.000334053124174906,4.23672214671628,0.310547202335165,6.70756063769544,"TRHDE","thyrotropin releasing hormone degrading enzyme",TRUE
+"1560698_a_at",0.140294357253668,0.000929501546343321,3.81816168769999,-0.592104928309789,3.07277869920785,"TRHDE-AS1","TRHDE antisense RNA 1",TRUE
+"1560697_at",0.514490373584066,0.0346597508389662,2.25065141437813,-3.7342688892702,1.90853206873064,"TRHDE-AS1","TRHDE antisense RNA 1",TRUE
+"211438_at",0.686025661550069,0.154257184225901,1.47509210638368,-4.93205386951995,0.399056946109675,"TRHR","thyrotropin releasing hormone receptor",TRUE
+"218403_at",0.757015081911646,0.252708278822261,-1.17438702077457,-5.28937170029732,-0.397820760323498,"TRIAP1","TP53 regulated inhibitor of apoptosis 1",TRUE
+"235641_at",0.784498961298069,0.307711042709229,1.04407001812517,-5.4222495225993,0.712439218374591,"TRIB1","tribbles pseudokinase 1",TRUE
+"202241_at",0.955730092376044,0.797188153560011,-0.260100375374658,-5.90678619905124,-0.182690286628008,"TRIB1","tribbles pseudokinase 1",TRUE
+"239818_x_at",0.994490435483257,0.974573343085375,-0.0322349034011978,-5.93917739148232,-0.0272494571643955,"TRIB1","tribbles pseudokinase 1",TRUE
+"202478_at",0.940964444369914,0.735600214989807,0.341964120761406,-5.882886531721,0.426121117395073,"TRIB2","tribbles pseudokinase 2",TRUE
+"202479_s_at",0.973567634886313,0.872841250978908,0.161913724251369,-5.92692266829864,0.110492742928517,"TRIB2","tribbles pseudokinase 2",TRUE
+"218145_at",0.73148417124022,0.214661715000289,-1.27746609182317,-5.17463469827914,-0.797570070704973,"TRIB3","tribbles pseudokinase 3",TRUE
+"1555788_a_at",0.7717895132349,0.281586830111184,-1.10365187063122,-5.36321677255364,-0.816217214945242,"TRIB3","tribbles pseudokinase 3",TRUE
+"205150_s_at",0.456853729334123,0.0223517828252177,-2.45597630454959,-3.3640997807875,-3.1681723380494,"TRIL","TLR4 interactor with leucine rich repeats",TRUE
+"205151_s_at",0.597878176656136,0.0751571414386396,-1.86722502918584,-4.37075352101284,-2.27148941593183,"TRIL","TLR4 interactor with leucine rich repeats",TRUE
+"221627_at",0.61760967235709,0.0882683413150465,1.78315198060025,-4.49937357416496,0.817764145021255,"TRIM10","tripartite motif containing 10",TRUE
+"210578_at",0.700875159747204,0.172504380881905,1.40972324267601,-5.01548273309644,0.693144533244404,"TRIM10","tripartite motif containing 10",TRUE
+"210579_s_at",0.802255823093278,0.339992113283852,-0.975193052653042,-5.48680603834263,-0.440907691420529,"TRIM10","tripartite motif containing 10",TRUE
+"56748_at",0.860085676417428,0.479243551558615,0.719682849512602,-5.6905128100075,0.3864487980392,"TRIM10","tripartite motif containing 10",TRUE
+"238797_at",0.842397669245069,0.436269397400885,0.792856789295385,-5.6380571137239,0.340388322820861,"TRIM11","tripartite motif containing 11",TRUE
+"226566_at",0.957017346544368,0.80538775607373,-0.249349167808126,-5.90944561787903,-0.092180766247413,"TRIM11","tripartite motif containing 11",TRUE
+"203659_s_at",0.758722841981575,0.255943246065076,1.1661756024172,-5.2981509166674,0.532788481836397,"TRIM13","tripartite motif containing 13",TRUE
+"1569142_at",0.759458601980339,0.256986622683827,1.16354361885912,-5.30095347655211,0.888953614142755,"TRIM13","tripartite motif containing 13",TRUE
+"230192_at",0.871619256677111,0.513077444350486,0.66473878574178,-5.72672292982915,0.653357180705758,"TRIM13","tripartite motif containing 13",TRUE
+"229943_at",0.982150737098109,0.914123213707336,0.109077070079253,-5.93389015852867,0.0502516491113081,"TRIM13","tripartite motif containing 13",TRUE
+"203147_s_at",0.664123571602771,0.132157268065069,1.56328311651391,-4.81469319133214,0.571789982357451,"TRIM14","tripartite motif containing 14",TRUE
+"210846_x_at",0.784498961298069,0.307602974413399,1.04430891435337,-5.42201869274181,0.378471498151343,"TRIM14","tripartite motif containing 14",TRUE
+"211044_at",0.843907019670627,0.440004707997267,0.78632813999972,-5.64293195376303,0.551946075647778,"TRIM14","tripartite motif containing 14",TRUE
+"231934_at",0.861113073516266,0.481294185567561,0.716290511123496,-5.69282783763294,0.404077881684739,"TRIM14","tripartite motif containing 14",TRUE
+"203148_s_at",0.874474734833648,0.520660839916294,0.652706507159401,-5.73428541622219,0.31989345024042,"TRIM14","tripartite motif containing 14",TRUE
+"210177_at",0.241793491518511,0.00323252179184985,3.30102475037522,-1.68904458287607,1.47616052654213,"TRIM15","tripartite motif containing 15",TRUE
+"36742_at",0.660460734341314,0.128537042926522,1.57887134830855,-4.79338908010699,0.643229617574514,"TRIM15","tripartite motif containing 15",TRUE
+"210885_s_at",0.705559553212919,0.177255476658568,1.39361845389054,-5.03556024220646,0.770604848676476,"TRIM15","tripartite motif containing 15",TRUE
+"204341_at",0.304824368772306,0.00592130969880997,3.04409449739347,-2.2185294598234,2.03990493868208,"TRIM16","tripartite motif containing 16",TRUE
+"1559682_at",0.646692716816097,0.117684336110491,1.62789877254379,-4.72531267347441,0.493479303457503,"TRIM16L","tripartite motif containing 16-like",TRUE
+"220279_at",0.398934416346185,0.0140477398108772,2.66646313420892,-2.96701309120489,1.99096458374649,"TRIM17","tripartite motif containing 17",TRUE
+"214248_s_at",0.697340169581683,0.167708492622616,1.42634353173065,-4.9945636443167,1.13993725977254,"TRIM2","tripartite motif containing 2",TRUE
+"215945_s_at",0.852470094272058,0.45838557106926,0.754684128202281,-5.66602092457238,0.886742599921336,"TRIM2","tripartite motif containing 2",TRUE
+"202342_s_at",0.853768202875953,0.462557324290654,0.747609184598792,-5.67106046822351,1.11858408096237,"TRIM2","tripartite motif containing 2",TRUE
+"202341_s_at",0.862800800218883,0.486604508355452,0.707544553837029,-5.69874829347686,0.946211131575684,"TRIM2","tripartite motif containing 2",TRUE
+"243945_at",0.893335389917274,0.567976677170631,-0.57968290299337,-5.77732667358017,-0.86018262273814,"TRIM2","tripartite motif containing 2",TRUE
+"214249_at",0.932806828930344,0.703178907296728,-0.385999032276604,-5.86737279802774,-0.317755001092543,"TRIM2","tripartite motif containing 2",TRUE
+"204804_at",0.861113073516266,0.481341339786084,0.716212603580894,-5.69288088169155,0.311797269579994,"TRIM21","tripartite motif containing 21",TRUE
+"213293_s_at",0.575983019059817,0.0610575308754748,1.97334517399046,-4.20248730043996,2.31365889566448,"TRIM22","tripartite motif containing 22",TRUE
+"204732_s_at",0.631316839203356,0.102555681756665,-1.70300680295132,-4.61793626420432,-0.747665808634124,"TRIM23","tripartite motif containing 23",TRUE
+"210994_x_at",0.695405041301046,0.16484946941569,-1.43643378547774,-4.9817655746657,-0.830146210805073,"TRIM23","tripartite motif containing 23",TRUE
+"210995_s_at",0.766550448794594,0.267467682307844,-1.13753327300084,-5.32835023563727,-0.427972149411684,"TRIM23","tripartite motif containing 23",TRUE
+"204390_at",0.447294524001345,0.0212019938147714,2.48023669397824,-3.31918885130976,0.712852938780219,"TRIM24","tripartite motif containing 24",TRUE
+"213301_x_at",0.54295328972902,0.0457603222388587,-2.11655423052106,-3.96558069270819,-0.920634098876196,"TRIM24","tripartite motif containing 24",TRUE
+"204391_x_at",0.60232392327634,0.0771481378089476,-1.85367569540835,-4.39176836451293,-0.866468913079522,"TRIM24","tripartite motif containing 24",TRUE
+"1569316_at",0.663819586595936,0.13184049468807,-1.56463287660432,-4.81285506654946,-0.849559403961341,"TRIM24","tripartite motif containing 24",TRUE
+"206911_at",0.635821858586292,0.10680595653256,1.68100751125163,-4.64976750796201,0.686162842615179,"TRIM25","tripartite motif containing 25",TRUE
+"224806_at",0.688234475234403,0.157686571033587,1.46234710850561,-4.94856139018067,0.448789570375149,"TRIM25","tripartite motif containing 25",TRUE
+"202702_at",0.937842878751575,0.72487833235801,0.356446237744766,-5.87798895930063,0.101973420979897,"TRIM26","tripartite motif containing 26",TRUE
+"210541_s_at",0.790754837130828,0.32043830217596,1.01633906022412,-5.44872043436668,0.320054065132782,"TRIM27","tripartite motif containing 27",TRUE
+"212116_at",0.835513930382091,0.414906972543286,0.830877669334843,-5.60891591611558,0.248137432444972,"TRIM27","tripartite motif containing 27",TRUE
+"212118_at",0.884769004468037,0.544624791076237,0.615300812953256,-5.75694722464588,0.175155059437964,"TRIM27","tripartite motif containing 27",TRUE
+"200990_at",0.851319596585235,0.455267027400249,0.75999815362271,-5.66220615964115,0.319090254235416,"TRIM28","tripartite motif containing 28",TRUE
+"202504_at",0.123615201675097,0.000705403619984092,3.93130332774836,-0.34875885814936,3.4056282147553,"TRIM29","tripartite motif containing 29",TRUE
+"211002_s_at",0.250890890784173,0.00356491743610197,3.25980741078973,-1.77486612183827,3.0610749946399,"TRIM29","tripartite motif containing 29",TRUE
+"211001_at",0.593904766176258,0.0706676237918604,1.89896643394835,-4.32110124528233,0.68148938391397,"TRIM29","tripartite motif containing 29",TRUE
+"213885_at",0.573647621198441,0.0603354286283819,-1.97934284890217,-4.19278717992553,-0.938733370113533,"TRIM3","tripartite motif containing 3",TRUE
+"204911_s_at",0.676020192063893,0.142461904946688,-1.52076700317769,-4.87194972976924,-0.925524466084497,"TRIM3","tripartite motif containing 3",TRUE
+"204910_s_at",0.710493083293363,0.183422219857079,-1.37321956043684,-5.06071683970244,-1.6767006042365,"TRIM3","tripartite motif containing 3",TRUE
+"213884_s_at",0.741186481976394,0.231540285544706,-1.23015628334001,-5.22832930403557,-1.79488721838565,"TRIM3","tripartite motif containing 3",TRUE
+"215444_s_at",0.384135218769668,0.0123133932536128,2.7251104077883,-2.85357147628268,1.44141032423425,"TRIM31","tripartite motif containing 31",TRUE
+"210159_s_at",0.484495305292367,0.0278572415175214,2.35380758733634,-3.55058253930463,1.42361577850446,"TRIM31","tripartite motif containing 31",TRUE
+"208170_s_at",0.683019114815084,0.151960066156508,1.48375836354852,-4.92076311374446,1.01599166320375,"TRIM31","tripartite motif containing 31",TRUE
+"236233_at",0.670152406964446,0.135873279613657,-1.5476458518927,-4.83589711218318,-0.542263028527723,"TRIM32","tripartite motif containing 32",TRUE
+"203846_at",0.73957587762701,0.228003613860103,-1.23984586757955,-5.21747382210941,-0.400999982727036,"TRIM32","tripartite motif containing 32",TRUE
+"214815_at",0.663252754612157,0.131187277729277,1.56742471173095,-4.80904914491092,0.800466744538217,"TRIM33","tripartite motif containing 33",TRUE
+"212436_at",0.767011398042819,0.268715504708646,-1.13448692483444,-5.3315232763254,-0.63186472644856,"TRIM33","tripartite motif containing 33",TRUE
+"210266_s_at",0.819018525257656,0.375300805693146,-0.904808187897093,-5.54861349901167,-0.591926456079431,"TRIM33","tripartite motif containing 33",TRUE
+"212435_at",0.833430578034454,0.410960921514566,-0.838034432294063,-5.60328770435078,-0.439250927026249,"TRIM33","tripartite motif containing 33",TRUE
+"227102_at",0.772742598605889,0.283317752750867,1.0995839420911,-5.3673401018487,0.412822863312673,"TRIM35","tripartite motif containing 35",TRUE
+"219736_at",0.446730129062715,0.0209897292079102,-2.48484881177426,-3.31062442286005,-2.09175912752064,"TRIM36","tripartite motif containing 36",TRUE
+"1565812_at",0.765228531154075,0.265274068535883,-1.14291402806832,-5.32272738226986,-0.325525878655279,"TRIM36","tripartite motif containing 36",TRUE
+"1565814_at",0.830635993561085,0.403595417402213,-0.851510626226918,-5.59256746161914,-0.632208838039741,"TRIM36","tripartite motif containing 36",TRUE
+"231123_at",0.846615322073696,0.445051458114074,0.77756106088976,-5.64941844665146,0.509705444316525,"TRIM36","tripartite motif containing 36",TRUE
+"213009_s_at",0.826234468040568,0.394461789104032,-0.868442454927327,-5.57887248795729,-0.555636700707188,"TRIM37","tripartite motif containing 37",TRUE
+"1554001_at",0.864957292343152,0.49405791019436,-0.695361421344449,-5.70687993944704,-0.566197505580153,"TRIM37","tripartite motif containing 37",TRUE
+"235084_x_at",0.527546822913581,0.0400653124667916,2.18113674853355,-3.85527351193751,0.92017129826444,"TRIM38","tripartite motif containing 38",TRUE
+"203610_s_at",0.538502554109027,0.0439232867228189,2.13655304013979,-3.93164547425471,1.54230393729254,"TRIM38","tripartite motif containing 38",TRUE
+"203568_s_at",0.586972146297368,0.0662787583308779,1.9317528065914,-4.26920249866559,1.46758321407659,"TRIM38","tripartite motif containing 38",TRUE
+"203567_s_at",0.610033432202476,0.0826208974020912,1.81794002530995,-4.44666959520533,2.74741562738294,"TRIM38","tripartite motif containing 38",TRUE
+"218836_at",0.869971289491322,0.508108628747566,0.672676320320146,-5.72166160694269,0.212814404871596,"TRIM39-RPP21///RPP21///TRIM39","TRIM39-RPP21 readthrough///ribonuclease P/MRP subunit p21///tripartite motif containing 39",TRUE
+"222732_at",0.847692162683017,0.446667844093222,0.774765956416513,-5.65147204006759,0.209106987327525,"TRIM39-RPP21///TRIM39","TRIM39-RPP21 readthrough///tripartite motif containing 39",TRUE
+"1554287_at",0.744550562232364,0.23548620525604,1.21947714041587,-5.24020822251898,0.980133089144338,"TRIM4","tripartite motif containing 4",TRUE
+"230173_at",0.813065886130395,0.362908158869187,0.928984355543184,-5.52786300428124,0.532861105380015,"TRIM4","tripartite motif containing 4",TRUE
+"224159_x_at",0.891653456393983,0.561658793979239,0.589243043312609,-5.77197195232296,0.166109107519775,"TRIM4","tripartite motif containing 4",TRUE
+"223384_s_at",0.913572663544659,0.637292812864107,0.478056648064076,-5.82897984087068,0.586955698394862,"TRIM4","tripartite motif containing 4",TRUE
+"1553079_at",0.991249206045988,0.959014343890529,0.0519750260244664,-5.93836781243815,0.0360794217377691,"TRIM40","tripartite motif containing 40",TRUE
+"226445_s_at",0.709158363400091,0.181920622191125,-1.37813596089738,-5.05468192645531,-0.627166068819315,"TRIM41","tripartite motif containing 41",TRUE
+"1566852_at",0.876572652459579,0.525238164924157,0.64549057192199,-5.73875715713667,0.333660308709153,"TRIM42","tripartite motif containing 42",TRUE
+"1566851_at",0.877271158601418,0.526643865883181,0.643281470730068,-5.74011659920073,0.229078330564614,"TRIM42","tripartite motif containing 42",TRUE
+"1553620_at",0.939976205834042,0.730233991431348,0.349202798350886,-5.88046364260797,0.133585033887048,"TRIM42","tripartite motif containing 42",TRUE
+"1553618_at",0.834457927981261,0.412978455843529,0.834369916988037,-5.60617518468621,0.515007841813879,"TRIM43B///TRIM43","tripartite motif containing 43B///tripartite motif containing 43",TRUE
+"1553619_a_at",0.987641938179343,0.941606983849652,0.0740857095357748,-5.93701049462427,0.0484691484598248,"TRIM43B///TRIM43","tripartite motif containing 43B///tripartite motif containing 43",TRUE
+"217759_at",0.734577729521114,0.219108724914546,1.26473253814362,-5.18925746974019,0.53002891962617,"TRIM44","tripartite motif containing 44",TRUE
+"217760_at",0.817815704063733,0.37036592122089,0.914370893529779,-5.54046609545278,0.352267274173556,"TRIM44","tripartite motif containing 44",TRUE
+"1556319_at",0.854184492233394,0.464044968776806,0.745095480994264,-5.67284017504668,0.608332728178594,"TRIM44","tripartite motif containing 44",TRUE
+"242056_at",0.69410086222651,0.163526514997312,-1.44115053924013,-4.97575775052119,-0.566858329401194,"TRIM45","tripartite motif containing 45",TRUE
+"219923_at",0.910165867297668,0.62626050371225,-0.493866961260283,-5.82157973778853,-0.206636156549136,"TRIM45","tripartite motif containing 45",TRUE
+"238147_at",0.830879340233824,0.404733597959715,0.849417977859414,-5.59424261580173,0.425035819223511,"TRIM46","tripartite motif containing 46",TRUE
+"220909_at",0.943464796017993,0.746697648897416,0.327052826307315,-5.88771934306107,0.241403724980405,"TRIM46","tripartite motif containing 46",TRUE
+"225868_at",0.661974206478491,0.129637715045941,1.57409387860438,-4.79993596371311,1.48298230963756,"TRIM47","tripartite motif containing 47",TRUE
+"221154_at",0.865187396415238,0.494391551227043,0.694818534442812,-5.70723915430922,0.459350719641914,"TRIM49C///TRIM49","tripartite motif containing 49C///tripartite motif containing 49",TRUE
+"223830_s_at",0.851319596585235,0.454512301978618,-0.761287498841213,-5.66127676468284,-0.64341566030183,"TRIM5","tripartite motif containing 5",TRUE
+"210705_s_at",0.91671872326659,0.648108594200384,0.462675753104003,-5.83595288058777,0.304655749086605,"TRIM5","tripartite motif containing 5",TRUE
+"1556554_at",0.830592576740524,0.40318287851332,0.852270048751332,-5.59195859758553,0.275911997529385,"TRIM50","tripartite motif containing 50",TRUE
+"231014_at",0.844169896707408,0.440655301988431,0.785194502979047,-5.64377455482852,0.434163319290659,"TRIM50","tripartite motif containing 50",TRUE
+"238941_at",0.929786324276714,0.690148212843127,-0.403913697408073,-5.8605318406803,-0.29983935317611,"TRIM50","tripartite motif containing 50",TRUE
+"223975_at",0.730389679155928,0.21309397463323,1.28200357114201,-5.16939381555171,0.549908268718638,"TRIM51","tripartite motif-containing 51",TRUE
+"221897_at",0.358427723880268,0.0101452226062655,-2.81056356935177,-2.6863031601151,-0.983167920329463,"TRIM52","tripartite motif containing 52",TRUE
+"1568594_s_at",0.729083413548563,0.210634006808673,-1.28917560835923,-5.16107769852384,-0.407531303493101,"TRIM52","tripartite motif containing 52",TRUE
+"1557507_at",0.730101539866086,0.212781413291233,-1.2829112871635,-5.16834348428704,-0.939972463183884,"TRIM52-AS1","TRIM52 antisense RNA 1 (head to head)",TRUE
+"228664_at",0.961690794738111,0.826373063107099,-0.221966561554357,-5.91571474321799,-0.174436456209849,"TRIM52-AS1","TRIM52 antisense RNA 1 (head to head)",TRUE
+"233669_s_at",0.8920930097751,0.563237106513744,-0.586849597217107,-5.77332049450137,-0.414403354702666,"TRIM54","tripartite motif containing 54",TRUE
+"236175_at",0.632216562924782,0.103321924377218,1.69898428159423,-4.62377981444052,1.23647549935945,"TRIM55","tripartite motif containing 55",TRUE
+"232721_at",0.92265243752289,0.669487284189533,0.432599482575757,-5.8489421415479,0.282253345357587,"TRIM55","tripartite motif containing 55",TRUE
+"231876_at",0.687734660055697,0.156993430032942,1.4649048593323,-4.94525785584226,0.538017064284626,"TRIM56","tripartite motif containing 56",TRUE
+"226040_at",0.837609393049242,0.421977712989168,0.818160490852097,-5.61880546688904,0.369969286242236,"TRIM56","tripartite motif containing 56",TRUE
+"241881_at",0.837241546504043,0.419776909269599,0.822104316217303,-5.61575382013248,0.74534756216076,"TRIM58","tripartite motif containing 58",TRUE
+"215047_at",0.932415412515157,0.701962531108583,-0.387665790468973,-5.86674922366162,-0.838918325444833,"TRIM58","tripartite motif containing 58",TRUE
+"227801_at",0.848475456105025,0.448782608757061,0.771118312952257,-5.65414150612313,0.654657961528949,"TRIM59","tripartite motif containing 59",TRUE
+"235476_at",0.861357981297227,0.481756347623849,0.715527124815513,-5.69334735945276,0.579365624613061,"TRIM59///IFT80","tripartite motif containing 59///intraflagellar transport 80",TRUE
+"223599_at",0.682539393883246,0.150171561678003,1.49057989056248,-4.91183827250071,1.60460469477496,"TRIM6","tripartite motif containing 6",TRUE
+"224175_s_at",0.878278790222455,0.531012623477886,0.636436277990309,-5.74430056630127,0.439295743734276,"TRIM6-TRIM34///TRIM34","TRIM6-TRIM34 readthrough///tripartite motif containing 34",TRUE
+"221044_s_at",0.937113154905832,0.720352323092151,0.36258276224834,-5.87585318291312,0.280390657769461,"TRIM6-TRIM34///TRIM34","TRIM6-TRIM34 readthrough///tripartite motif containing 34",TRUE
+"240342_at",0.900867933475689,0.596818570227462,0.53670701642124,-5.80034836180356,0.231655751044547,"TRIM61","tripartite motif containing 61",TRUE
+"238990_x_at",0.943464796017993,0.747066384816868,-0.326558681543442,-5.88787584818095,-0.145974111450766,"TRIM61","tripartite motif containing 61",TRUE
+"219272_at",0.660054711393139,0.127976110888798,-1.58131915502053,-4.79002867257631,-0.565791840261151,"TRIM62","tripartite motif containing 62",TRUE
+"58308_at",0.722361701458388,0.198826177325053,-1.32453426868289,-5.11950423996929,-0.528060372414398,"TRIM62","tripartite motif containing 62",TRUE
+"236845_at",0.925820623036756,0.678901257236629,-0.419484735612312,-5.85433776771468,-0.255987079241486,"TRIM62","tripartite motif containing 62",TRUE
+"236972_at",0.901298810621856,0.597983670501954,0.534992791202324,-5.80123093779299,0.459001574885522,"TRIM63","tripartite motif containing 63",TRUE
+"1561997_at",0.975398143273847,0.882312894559162,-0.14975480915267,-5.92876625766697,-0.128550797464313,"TRIM64EP","tripartite motif containing 64E, pseudogene",TRUE
+"239374_at",0.687545925823023,0.156549884353612,1.46654638515189,-4.94313523295363,0.385992836239806,"TRIM65","tripartite motif containing 65",TRUE
+"235081_x_at",0.957430653957785,0.807316880710365,0.246824132282286,-5.91005403222606,0.0625650977072993,"TRIM65","tripartite motif containing 65",TRUE
+"237679_at",0.267497559720232,0.00409346751999664,3.20138735376295,-1.89596709986147,1.68999477817646,"TRIM66","tripartite motif containing 66",TRUE
+"229466_at",0.522596516335368,0.0382902907076266,2.20297002575472,-3.81751731858608,0.761065526590688,"TRIM66","tripartite motif containing 66",TRUE
+"213748_at",0.735677568529031,0.220707806124119,1.26020225049604,-5.19442967626004,0.501356263481602,"TRIM66","tripartite motif containing 66",TRUE
+"233357_at",0.630603891142543,0.101638372848302,1.70785611055887,-4.61087784604151,0.997635651396241,"TRIM67","tripartite motif containing 67",TRUE
+"219405_at",0.906476756086155,0.614001565923102,0.511586332882975,-5.81300676081409,0.504696297935418,"TRIM68","tripartite motif containing 68",TRUE
+"232792_at",0.468735421183467,0.0249385429757503,2.4053748315905,-3.45700553837632,1.40549962070108,"TRIM69","tripartite motif containing 69",TRUE
+"229037_at",0.56861088242915,0.0586030603107135,1.99399511356045,-4.16900639681847,0.903281702289309,"TRIM69","tripartite motif containing 69",TRUE
+"1568592_at",0.755176183644208,0.249156345253916,1.18349367636311,-5.27957238676427,0.518727100301346,"TRIM69","tripartite motif containing 69",TRUE
+"239694_at",0.715692660338369,0.191492783321262,1.34732746981192,-5.09220267096979,0.873600370487261,"TRIM7","tripartite motif containing 7",TRUE
+"1554735_a_at",0.796378050779806,0.328776801427007,0.998586002186961,-5.46532830502335,0.671650043989233,"TRIM7","tripartite motif containing 7",TRUE
+"223694_at",0.821424121108148,0.383511173814356,0.889080439973457,-5.56184126360598,1.0135004467624,"TRIM7","tripartite motif containing 7",TRUE
+"231310_at",0.886024094987978,0.548686298699948,0.609049295008327,-5.76060901274856,0.519579955853764,"TRIM71","tripartite motif containing 71",TRUE
+"1554803_s_at",0.960664106415106,0.821347661575065,0.228507353247402,-5.91428313496279,0.122015426700875,"TRIM72","tripartite motif containing 72",TRUE
+"1554182_at",0.925091998149497,0.675753585568633,0.423861370539709,-5.85255529328818,0.323784217305055,"TRIM74///TRIM73","tripartite motif containing 74///tripartite motif containing 73",TRUE
+"1554183_s_at",0.996236827336335,0.981204447225635,-0.02382629731276,-5.9394069824731,-0.0175224571874599,"TRIM74///TRIM73","tripartite motif containing 74///tripartite motif containing 73",TRUE
+"232464_at",0.763356510523603,0.26306654542818,1.14836207399405,-5.31701040883298,0.57681237426983,"TRIM78P","tripartite motif containing 78, pseudogene",TRUE
+"223131_s_at",0.704136697708699,0.175970906138571,1.39793847816308,-5.03019324740829,0.70469139992387,"TRIM8","tripartite motif containing 8",TRUE
+"223132_s_at",0.739189560382301,0.225980460201944,1.24544033389892,-5.21117281739849,0.506543010254298,"TRIM8","tripartite motif containing 8",TRUE
+"221012_s_at",0.75710709622615,0.252940097822579,1.17379599459788,-5.2900053942537,0.522400946098028,"TRIM8","tripartite motif containing 8",TRUE
+"228015_s_at",0.841550580403629,0.433281284352226,0.798104299269749,-5.63411139024728,0.434884137839771,"TRIM8","tripartite motif containing 8",TRUE
+"231161_x_at",0.888232641270866,0.553859485879537,0.601121902129724,-5.76520053851376,0.38406439724888,"TRIM8","tripartite motif containing 8",TRUE
+"230280_at",0.973433731874338,0.871484161240807,0.163657848719184,-5.92664644849868,0.10133515299137,"TRIM9","tripartite motif containing 9",TRUE
+"209859_at",0.986342822130003,0.934076146022573,-0.0836623944217321,-5.93627490784568,-0.102450009601261,"TRIM9","tripartite motif containing 9",TRUE
+"1557677_a_at",0.299994279961527,0.00560757483531195,3.06741880970677,-2.17104465146237,1.3101548936792,"TRIML1","tripartite motif family like 1",TRUE
+"1552580_at",0.744573608322482,0.235636668140602,1.21907262144251,-5.2406564279512,0.672640541796549,"TRIML2","tripartite motif family like 2",TRUE
+"209011_at",0.280199223932988,0.00456224093110877,3.15539625232042,-1.99083075505868,1.66124221852184,"TRIO","trio Rho guanine nucleotide exchange factor",TRUE
+"208178_x_at",0.296090407530139,0.00535228016130412,3.08734534810438,-2.13037748303377,1.91884539062192,"TRIO","trio Rho guanine nucleotide exchange factor",TRUE
+"209012_at",0.308621629697291,0.00634519739157559,3.01440188682979,-2.27879213780528,1.60575304412023,"TRIO","trio Rho guanine nucleotide exchange factor",TRUE
+"231403_at",0.33674956679626,0.00834559968923516,2.89589268643135,-2.5170954514484,1.44881893730569,"TRIO","trio Rho guanine nucleotide exchange factor",TRUE
+"209013_x_at",0.396220771188728,0.0136494450982359,2.67930124588487,-2.94227832693864,2.1654725615407,"TRIO","trio Rho guanine nucleotide exchange factor",TRUE
+"216697_at",0.501717436797406,0.0323099605846121,2.28400357032296,-3.67540615552922,1.38041739819155,"TRIO","trio Rho guanine nucleotide exchange factor",TRUE
+"244527_at",0.51470556386048,0.0353722949494926,2.24094553502309,-3.75130173425879,0.793598431129697,"TRIO","trio Rho guanine nucleotide exchange factor",TRUE
+"209010_s_at",0.569936550799515,0.0589481700003888,1.99104584539197,-4.17380258077289,2.24321618151518,"TRIO","trio Rho guanine nucleotide exchange factor",TRUE
+"216700_at",0.895690630367785,0.575517948681369,0.568342429834452,-5.7835685896285,0.494753713146275,"TRIO","trio Rho guanine nucleotide exchange factor",TRUE
+"243690_at",0.73759219552868,0.224164456427542,1.25049461366234,-5.20545925733385,0.444624829402816,"TRIOBP","TRIO and F-actin binding protein",TRUE
+"1552332_at",0.783297797848606,0.305915360753996,1.04804729108359,-5.41840035719759,0.611820521196501,"TRIOBP","TRIO and F-actin binding protein",TRUE
+"202795_x_at",0.831875452294783,0.40687396383169,0.845492882178163,-5.59737426617674,0.299825432943331,"TRIOBP","TRIO and F-actin binding protein",TRUE
+"1552334_at",0.841088238127348,0.43080493757289,0.802470058610853,-5.6308100281269,0.390909246875191,"TRIOBP","TRIO and F-actin binding protein",TRUE
+"216210_x_at",0.852006864319744,0.457171143638825,0.756750934232691,-5.66454024138533,0.306872236713154,"TRIOBP","TRIO and F-actin binding protein",TRUE
+"202734_at",0.812302873476553,0.360346110633104,0.934050945261919,-5.52345050824399,0.541026610904908,"TRIP10","thyroid hormone receptor interactor 10",TRUE
+"236160_at",0.446720401893991,0.0209661576003049,-2.48536365382221,-3.30966787126362,-0.840361752055934,"TRIP11","thyroid hormone receptor interactor 11",TRUE
+"230211_at",0.46584896273628,0.024257181577929,-2.41821378355399,-3.43353266199266,-2.05117332140087,"TRIP11","thyroid hormone receptor interactor 11",TRUE
+"210760_x_at",0.719412173140763,0.195397242126419,-1.3351083837929,-5.10688728606441,-0.409516039105222,"TRIP11","thyroid hormone receptor interactor 11",TRUE
+"209778_at",0.769847953580141,0.278370378311075,-1.11125944918846,-5.35546930746706,-0.379512844267943,"TRIP11","thyroid hormone receptor interactor 11",TRUE
+"235973_at",0.867420080555634,0.499764059580851,0.686105223271561,-5.7129678797938,0.332166232284823,"TRIP11","thyroid hormone receptor interactor 11",TRUE
+"226993_at",0.916107385524794,0.646118583102298,-0.465497104769496,-5.83469052009525,-0.276911400240452,"TRIP12","thyroid hormone receptor interactor 12",TRUE
+"201546_at",0.97928472590149,0.899377707720519,-0.127905328814552,-5.93171837846248,-0.0370948746101707,"TRIP12","thyroid hormone receptor interactor 12",TRUE
+"244659_at",0.980009054680439,0.90535073214038,-0.120273172761162,-5.93264025791077,-0.0532251682288178,"TRIP12","thyroid hormone receptor interactor 12",TRUE
+"204033_at",0.689932696175004,0.159173498482881,1.45689076944938,-4.95559302203822,0.895459357587123,"TRIP13","thyroid hormone receptor interactor 13",TRUE
+"203732_at",0.287796329902695,0.00490526835931111,-3.12455267429957,-2.05420397983926,-1.00123016876287,"TRIP4","thyroid hormone receptor interactor 4",TRUE
+"209129_at",0.914242258486146,0.639364816709512,0.475101135325757,-5.83033706396872,0.4671473853551,"TRIP6","thyroid hormone receptor interactor 6",TRUE
+"224158_s_at",0.838152149721361,0.422747541524755,0.816784008353601,-5.61986732150981,0.578326632045771,"TRIQK","triple QxxK/R motif containing",TRUE
+"225603_s_at",0.899998627338565,0.594469988609179,-0.540167470171948,-5.79855836734272,-0.299249090779142,"TRIQK","triple QxxK/R motif containing",TRUE
+"225599_s_at",0.9075549591285,0.616755593257952,-0.507591319470227,-5.8149653675534,-0.338847681425129,"TRIQK","triple QxxK/R motif containing",TRUE
+"225600_at",0.919375181609246,0.657339453393562,-0.44963790916865,-5.84168873108617,-0.21395127996152,"TRIQK","triple QxxK/R motif containing",TRUE
+"1562066_at",0.970271320001985,0.858591829696106,0.180253759857655,-5.92387048858127,0.0845662229100967,"TRIQK","triple QxxK/R motif containing",TRUE
+"218617_at",0.92658460686878,0.680613889281336,0.41710693163499,-5.85529855165327,0.129845530003777,"TRIT1","tRNA isopentenyltransferase 1",TRUE
+"222195_s_at",0.899808883319249,0.591986742817521,0.543833613921291,-5.79664977513897,0.359689918383585,"TRMO","tRNA methyltransferase O",TRUE
+"222188_at",0.962966981693287,0.83199052463797,0.214666865533905,-5.91726359567134,0.19345302408569,"TRMO","tRNA methyltransferase O",TRUE
+"47530_at",0.996140682541913,0.980696140159201,-0.0244707885381788,-5.93939182206182,-0.00717177423283744,"TRMO","tRNA methyltransferase O",TRUE
+"210463_x_at",0.598790786356002,0.0756554477395356,1.86380481584961,-4.37606845711965,0.924897401838658,"TRMT1","tRNA methyltransferase 1",TRUE
+"203701_s_at",0.657015752622694,0.125255922586169,1.59331764080616,-4.77349808041711,0.634499511365666,"TRMT1","tRNA methyltransferase 1",TRUE
+"216454_at",0.985361089461736,0.927546030019701,0.091972960455869,-5.93556424102919,0.067428890550373,"TRMT1","tRNA methyltransferase 1",TRUE
+"230243_at",0.722192678020526,0.198489225080245,-1.32556701133569,-5.11827570079611,-0.421624441100368,"TRMT10A","tRNA methyltransferase 10A",TRUE
+"231877_at",0.774230543658252,0.290122189507183,-1.08376447383809,-5.38324613842694,-0.356021207879072,"TRMT10A","tRNA methyltransferase 10A",TRUE
+"242442_x_at",0.820536502908875,0.380554291290221,-0.8947189050471,-5.55712372916567,-0.389237205353029,"TRMT10A","tRNA methyltransferase 10A",TRUE
+"240166_x_at",0.875390771321967,0.522704755580215,0.64948008624003,-5.73629073997584,0.313522835758907,"TRMT10B","tRNA methyltransferase 10B",TRUE
+"235303_at",0.911143250035311,0.62909226841828,-0.489796752237585,-5.82350731054545,-0.16309916583595,"TRMT10B","tRNA methyltransferase 10B",TRUE
+"223267_at",0.816966928109267,0.369237589203406,-0.916569198793087,-5.53858197553621,-0.252156784622203,"TRMT10C","tRNA methyltransferase 10C, mitochondrial RNase P subunit",TRUE
+"218877_s_at",0.497871139123625,0.0309106518586103,2.30493519036908,-3.63820453555796,0.89519279958432,"TRMT11","tRNA methyltransferase 11 homolog",TRUE
+"217774_s_at",0.84176002413858,0.433695561319641,-0.797375444392781,-5.63466089687029,-0.254560094830387,"TRMT112","tRNA methyltransferase 11-2 homolog (S. cerevisiae)",TRUE
+"219299_at",0.800652137530934,0.336588740395949,-0.982234939551502,-5.48038943359425,-0.669978223942248,"TRMT12","tRNA methyltransferase 12 homolog",TRUE
+"219130_at",0.869094925545835,0.50603817018293,-0.675996642964091,-5.71952736274634,-0.283538693046006,"TRMT13","tRNA methyltransferase 13 homolog",TRUE
+"232489_at",0.931370027472813,0.696469304182301,0.395206995235695,-5.86389479015639,0.353816182059795,"TRMT13","tRNA methyltransferase 13 homolog",TRUE
+"220992_s_at",0.884757591377679,0.544350445658047,-0.615723978015663,-5.75669805537225,-0.219092808057184,"TRMT1L","tRNA methyltransferase 1 like",TRUE
+"223404_s_at",0.94895689004559,0.767944267110447,-0.298710865336505,-5.89631692645708,-0.101667363172561,"TRMT1L","tRNA methyltransferase 1 like",TRUE
+"233750_s_at",0.989108041907445,0.947001328410815,0.0672303379671835,-5.93748223494167,0.0198938303856711,"TRMT1L","tRNA methyltransferase 1 like",TRUE
+"218475_at",0.813065886130395,0.362476535709225,-0.929836231995662,-5.52712264777089,-0.543657976343637,"TRMT2A","tRNA methyltransferase 2 homolog A",TRUE
+"1554279_a_at",0.897375964261386,0.583701017100556,0.556121371825529,-5.79016132844767,0.388634853051649,"TRMT2B","tRNA methyltransferase 2 homolog B",TRUE
+"205238_at",0.983136574792668,0.917971747228907,0.104169871403155,-5.9343995640713,0.0366923806200443,"TRMT2B","tRNA methyltransferase 2 homolog B",TRUE
+"235097_at",0.805746717966166,0.345224783936059,-0.964459731852514,-5.49650525668487,-0.642237723651906,"TRMT44","tRNA methyltransferase 44 homolog (S. cerevisiae)",TRUE
+"220891_at",0.861357981297227,0.481834656905248,0.715397817946613,-5.69343530690456,0.480918506503707,"TRMT44","tRNA methyltransferase 44 homolog (S. cerevisiae)",TRUE
+"1554192_s_at",0.88767000285873,0.552401486088334,-0.60335219113647,-5.76391463132577,-0.155778438208403,"TRMT44","tRNA methyltransferase 44 homolog (S. cerevisiae)",TRUE
+"221952_x_at",0.846248434359032,0.444246494176194,0.778955336712856,-5.64839144965788,0.227743893678818,"TRMT5","tRNA methyltransferase 5",TRUE
+"227653_at",0.851733415458562,0.455881105087677,-0.758950034614885,-5.66296057442234,-0.236849519873747,"TRMT5","tRNA methyltransferase 5",TRUE
+"222768_s_at",0.914777625972484,0.641172125973522,0.472526685906427,-5.8315125846386,0.234558863523969,"TRMT6","tRNA methyltransferase 6",TRUE
+"233970_s_at",0.970437050110553,0.85914961884959,-0.179534695614973,-5.92399630091406,-0.0947931202978278,"TRMT6","tRNA methyltransferase 6",TRUE
+"221907_at",0.820293495506061,0.379297299417885,-0.897124565593412,-5.55510258574046,-0.298903291027834,"TRMT61A","tRNA methyltransferase 61A",TRUE
+"52741_at",0.838682969007165,0.423890108473536,-0.814743944926208,-5.62143799649811,-0.270670542576596,"TRMT61A","tRNA methyltransferase 61A",TRUE
+"1554317_s_at",0.888232641270866,0.553925483576083,-0.601021018845041,-5.7652585956052,-0.207939628138298,"TRMT61A","tRNA methyltransferase 61A",TRUE
+"221229_s_at",0.625490878792938,0.0966713135736805,1.7347807642287,-4.57141504709837,0.579337531701134,"TRMT61B","tRNA methyltransferase 61B",TRUE
+"213634_s_at",0.868397087637799,0.503421519066063,-0.68020382673538,-5.7168086208159,-0.341539496189169,"TRMU","tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase",TRUE
+"204317_at",0.808257777979515,0.350846237955539,0.953051742708443,-5.50670655901461,0.432885941480725,"TRMU///GTSE1","tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase///G2 and S-phase expressed 1",TRUE
+"228997_at",0.358427723880268,0.00978342083733401,2.82649208623267,-2.65487725952649,2.08400662813097,"TRNAU1AP","tRNA selenocysteine 1 associated protein 1",TRUE
+"222800_at",0.485255613602953,0.0280567492205996,-2.35046738228289,-3.55660452331515,-1.26676872420998,"TRNAU1AP","tRNA selenocysteine 1 associated protein 1",TRUE
+"223965_at",0.822173415758858,0.386305988882166,0.883777118116233,-5.56625317806425,0.311030631864742,"TRNAU1AP","tRNA selenocysteine 1 associated protein 1",TRUE
+"218977_s_at",0.941436486910987,0.738186074629372,0.33848263267125,-5.88403396434956,0.102731268223998,"TRNAU1AP","tRNA selenocysteine 1 associated protein 1",TRUE
+"227862_at",0.774230543658252,0.28985908617306,1.08437115692245,-5.38263992375923,0.786662505578398,"TRNP1","TMF1-regulated nuclear protein 1",TRUE
+"236052_at",0.964685626382167,0.836604043043774,0.208680686341382,-5.91849526697602,0.134715372544943,"TRNP1","TMF1-regulated nuclear protein 1",TRUE
+"223814_at",0.868045863234681,0.501931437602564,-0.68260516988321,-5.71524960808134,-0.301366585219732,"TRNT1","tRNA nucleotidyl transferase 1",TRUE
+"222754_at",0.910165867297668,0.626621981393843,-0.493346925154612,-5.82182688516769,-0.213464986171017,"TRNT1","tRNA nucleotidyl transferase 1",TRUE
+"1552625_a_at",0.920749013376768,0.662839513813989,-0.441907129347433,-5.84501386697213,-0.169954111017114,"TRNT1","tRNA nucleotidyl transferase 1",TRUE
+"211701_s_at",0.565956563686213,0.056844189619418,2.00927009070215,-4.14408969977352,1.35739283816095,"TRO","trophinin",TRUE
+"210882_s_at",0.747751855148757,0.239608824914608,1.20846337853251,-5.25236543597047,0.76024538494338,"TRO","trophinin",TRUE
+"211700_s_at",0.856257656023992,0.470094713652917,0.734922110029971,-5.67998488557226,0.74274518402103,"TRO","trophinin",TRUE
+"205028_at",0.985498770484702,0.930191611169253,0.0886052900813169,-5.93586032138801,0.0700130974002504,"TRO","trophinin",TRUE
+"204649_at",0.635222294679416,0.106073700053463,-1.68474407380465,-4.64438301473109,-0.477802961342602,"TROAP","trophinin associated protein",TRUE
+"1568596_a_at",0.939481320547208,0.728972209289342,-0.35090760911731,-5.8798857201819,-0.112358709371101,"TROAP","trophinin associated protein",TRUE
+"212839_s_at",0.290430545694223,0.00505433570144676,-3.11179375342667,-2.08035941197173,-1.05966769440192,"TROVE2","TROVE domain family member 2",TRUE
+"213027_at",0.561084367279569,0.0546839245152516,-2.02861674231716,-4.1123494981669,-0.62791574273454,"TROVE2","TROVE domain family member 2",TRUE
+"212852_s_at",0.594972224548427,0.0717445933676549,-1.891194683864,-4.33331267639857,-0.585134511808585,"TROVE2","TROVE domain family member 2",TRUE
+"210438_x_at",0.632949074657601,0.103708471380228,-1.69696464572744,-4.62670983819454,-0.54762939285267,"TROVE2","TROVE domain family member 2",TRUE
+"207520_at",0.962555471240652,0.829664818817648,0.217687569307477,-5.91662891393934,0.0937504673232477,"TROVE2","TROVE domain family member 2",TRUE
+"217590_s_at",0.846552177460323,0.444883104068907,0.777852539226666,-5.64920389272375,0.987438886337499,"TRPA1","transient receptor potential cation channel subfamily A member 1",TRUE
+"208349_at",0.942502815705589,0.741772871530768,0.333660568586846,-5.88560404281405,0.11196380200411,"TRPA1","transient receptor potential cation channel subfamily A member 1",TRUE
+"205803_s_at",0.795497760925102,0.327683688584272,1.00089533357159,-5.46318295516356,1.02799428374298,"TRPC1","transient receptor potential cation channel subfamily C member 1",TRUE
+"205802_at",0.805168768064335,0.344397975160626,0.966148267520577,-5.4949859001103,1.31795242966728,"TRPC1","transient receptor potential cation channel subfamily C member 1",TRUE
+"211602_s_at",0.866812325829005,0.498339356229555,0.688410638629204,-5.71145885994205,0.757602405184519,"TRPC1","transient receptor potential cation channel subfamily C member 1",TRUE
+"215288_at",0.89316156038085,0.567249228561678,0.580780877948404,-5.77671599628366,0.454290381252231,"TRPC2","transient receptor potential cation channel subfamily C member 2, pseudogene",TRUE
+"206425_s_at",0.66821692116892,0.134345944820635,1.55402968716482,-4.82726102109431,0.641287262885409,"TRPC3","transient receptor potential cation channel subfamily C member 3",TRUE
+"210814_at",0.951175264030662,0.776893164441103,-0.286849166773031,-5.89968600972778,-0.262101922150523,"TRPC3","transient receptor potential cation channel subfamily C member 3",TRUE
+"220817_at",0.660234446131062,0.128291371846299,1.57994231850355,-4.79191932773761,1.54444184322762,"TRPC4","transient receptor potential cation channel subfamily C member 4",TRUE
+"220818_s_at",0.92265243752289,0.66949044634377,0.432595064488503,-5.84894398669695,0.354932775777013,"TRPC4","transient receptor potential cation channel subfamily C member 4",TRUE
+"224219_s_at",0.93527815307551,0.712155914500694,0.373732145846262,-5.87188062725092,0.369597262019215,"TRPC4","transient receptor potential cation channel subfamily C member 4",TRUE
+"224220_x_at",0.952789431929983,0.783892583749546,0.277600776012236,-5.90221887404866,0.203191152773947,"TRPC4","transient receptor potential cation channel subfamily C member 4",TRUE
+"212059_s_at",0.635174103121116,0.10602227180066,-1.68500732257661,-4.64400332499264,-0.772389344347026,"TRPC4AP","transient receptor potential cation channel subfamily C member 4 associated protein",TRUE
+"220552_at",0.605913415325856,0.0794363511468381,1.83847466777166,-4.41521533344633,1.58800713107882,"TRPC5","transient receptor potential cation channel subfamily C member 5",TRUE
+"231138_at",0.959203345279235,0.815347946043487,-0.236329657010915,-5.91251672761576,-0.177777934787871,"TRPC5OS","TRPC5 opposite strand",TRUE
+"217287_s_at",0.940875142749531,0.73519906216165,0.342504600562982,-5.88270735867181,0.393584733403126,"TRPC6","transient receptor potential cation channel subfamily C member 6",TRUE
+"206528_at",0.962741248200658,0.830494540439148,-0.21660966315432,-5.91685640650187,-0.264232174071381,"TRPC6","transient receptor potential cation channel subfamily C member 6",TRUE
+"234407_s_at",0.838583471723463,0.423639946455853,-0.815190317035467,-5.62109464278137,-0.834382720982987,"TRPC7","transient receptor potential cation channel subfamily C member 7",TRUE
+"208589_at",0.996414653701559,0.982377063084542,0.0223395565909477,-5.93944041199772,0.00902225797350198,"TRPC7","transient receptor potential cation channel subfamily C member 7",TRUE
+"206479_at",0.711977799428804,0.18581612075454,1.36544713558809,-5.07022092429705,1.31343540924192,"TRPM1","transient receptor potential cation channel subfamily M member 1",TRUE
+"237070_at",0.856257656023992,0.470033683009991,0.735024352133823,-5.67991354498896,0.949064132268231,"TRPM1","transient receptor potential cation channel subfamily M member 1",TRUE
+"237069_s_at",0.906507435035949,0.61437367020482,0.511046063916917,-5.81327251018696,0.313660720183179,"TRPM1","transient receptor potential cation channel subfamily M member 1",TRUE
+"214410_at",0.998384473324293,0.993416963870336,-0.00834430204865141,-5.93964956787795,-0.00695732522477632,"TRPM1","transient receptor potential cation channel subfamily M member 1",TRUE
+"205708_s_at",0.704331267592907,0.176227741027361,1.39707273539813,-5.03126990523784,1.00489724538293,"TRPM2","transient receptor potential cation channel subfamily M member 2",TRUE
+"1564242_at",0.90427866743639,0.606771231114838,0.522115194623193,-5.80777315628938,0.371999728490595,"TRPM2-AS","TRPM2 antisense RNA",TRUE
+"220463_at",0.59593805567542,0.0724667899531252,-1.88604009408859,-4.34139252389511,-0.847164979384071,"TRPM3","transient receptor potential cation channel subfamily M member 3",TRUE
+"216452_at",0.676468346171966,0.143370783785083,1.51713976616716,-4.87677646171096,0.803825762591538,"TRPM3","transient receptor potential cation channel subfamily M member 3",TRUE
+"1554722_at",0.709914655587487,0.18283767310625,-1.37512962887406,-5.05837434768152,-0.919138795898403,"TRPM3","transient receptor potential cation channel subfamily M member 3",TRUE
+"1555252_a_at",0.877333806479767,0.527135069166492,0.642510289342835,-5.74059011627836,0.225191013079118,"TRPM3","transient receptor potential cation channel subfamily M member 3",TRUE
+"239684_at",0.950203015588328,0.773752879012776,0.291006719608611,-5.89852054768873,0.21194880628627,"TRPM3","transient receptor potential cation channel subfamily M member 3",TRUE
+"211422_at",0.977063818674184,0.890539736208621,-0.139212660729686,-5.93024852306616,-0.0830057223550043,"TRPM3","transient receptor potential cation channel subfamily M member 3",TRUE
+"239291_at",0.986342822130003,0.935047571226517,-0.0824266382643406,-5.9363748421626,-0.080524643016286,"TRPM3","transient receptor potential cation channel subfamily M member 3",TRUE
+"233022_at",0.994379916442633,0.974301353520773,0.0325798478005999,-5.9391665025267,0.0137515855159984,"TRPM3","transient receptor potential cation channel subfamily M member 3",TRUE
+"219360_s_at",0.722937902375896,0.199524795494528,-1.32239738511593,-5.12204369071122,-1.66534067085409,"TRPM4","transient receptor potential cation channel subfamily M member 4",TRUE
+"223935_at",0.661922323643,0.129176244961515,-1.57609277590838,-4.79719863279226,-0.836977466305183,"TRPM5","transient receptor potential cation channel subfamily M member 5",TRUE
+"221102_s_at",0.482907175487065,0.0275871893435744,2.35836412917402,-3.54235984027105,1.57960109785852,"TRPM6","transient receptor potential cation channel subfamily M member 6",TRUE
+"224412_s_at",0.70772084164277,0.179263312765021,1.38691572140083,-5.04386019400395,0.711713211993346,"TRPM6","transient receptor potential cation channel subfamily M member 6",TRUE
+"234864_s_at",0.844864826163386,0.441894822748868,0.783037516290338,-5.64537462046292,0.340252365104237,"TRPM6","transient receptor potential cation channel subfamily M member 6",TRUE
+"240389_at",0.886023097762234,0.54834675919324,0.60957097845771,-5.7603048192917,0.401666468514573,"TRPM6","transient receptor potential cation channel subfamily M member 6",TRUE
+"223324_s_at",0.725276957219979,0.204086142130935,-1.30858706175682,-5.13837224680073,-0.551228430424473,"TRPM7","transient receptor potential cation channel subfamily M member 7",TRUE
+"239484_at",0.750128656946777,0.243032081008783,-1.19942602524786,-5.26226956223065,-0.960057576870388,"TRPM7","transient receptor potential cation channel subfamily M member 7",TRUE
+"231689_at",0.837609393049242,0.421849993017454,0.818389011093817,-5.6186290181892,0.347220041093492,"TRPM7","transient receptor potential cation channel subfamily M member 7",TRUE
+"223323_x_at",0.87579870142401,0.523681459156452,-0.647940758899054,-5.7372441195461,-0.37531428455563,"TRPM7","transient receptor potential cation channel subfamily M member 7",TRUE
+"237884_x_at",0.928653409465831,0.686362766831536,-0.409142995239116,-5.8584773604644,-0.201257090098821,"TRPM7","transient receptor potential cation channel subfamily M member 7",TRUE
+"243483_at",0.620223198657182,0.0899698695770073,1.77304714361831,-4.51454339358769,1.50582565832182,"TRPM8","transient receptor potential cation channel subfamily M member 8",TRUE
+"220226_at",0.905462783815257,0.611522980613658,0.515189011168584,-5.81122766398641,0.152708556295818,"TRPM8","transient receptor potential cation channel subfamily M member 8",TRUE
+"222651_s_at",0.482907175487065,0.0275921722217026,-2.35827968261639,-3.54251231364791,-2.53649415621643,"TRPS1","transcriptional repressor GATA binding 1",TRUE
+"218502_s_at",0.524357022515583,0.0390426600578132,-2.1936058474913,-3.83373904570514,-2.62864518446075,"TRPS1","transcriptional repressor GATA binding 1",TRUE
+"224218_s_at",0.581813873328156,0.0640181483665695,-1.9493925516275,-4.24102656207226,-2.18379155964119,"TRPS1","transcriptional repressor GATA binding 1",TRUE
+"234351_x_at",0.62524538993269,0.0965159080047289,-1.73564204513673,-4.57014510543541,-1.97420352477967,"TRPS1","transcriptional repressor GATA binding 1",TRUE
+"223436_s_at",0.498703893437511,0.0313001169208201,-2.29902355778106,-3.64873130926843,-0.733926749057659,"TRPT1","tRNA phosphotransferase 1",TRUE
+"222855_s_at",0.637485146909712,0.108594695397512,1.67197029777647,-4.66275295336632,0.821143427450819,"TRPV2","transient receptor potential cation channel subfamily V member 2",TRUE
+"219282_s_at",0.718706241731185,0.194606011777856,1.33756897794905,-5.10393922914941,0.678658299777303,"TRPV2","transient receptor potential cation channel subfamily V member 2",TRUE
+"1555291_at",0.744400501967131,0.235353491203859,1.21983410399882,-5.23981260142505,0.573955812577773,"TRPV3","transient receptor potential cation channel subfamily V member 3",TRUE
+"1552586_at",0.762192206662119,0.261564012320097,1.15208955888299,-5.31308515067795,0.356050434043925,"TRPV3","transient receptor potential cation channel subfamily V member 3",TRUE
+"219516_at",0.511865439796757,0.0341805344434926,2.25728193745549,-3.72260771409232,2.17104673987465,"TRPV4","transient receptor potential cation channel subfamily V member 4",TRUE
+"208267_at",0.610455440146151,0.0829432121559527,1.81590009441138,-4.44978041823684,0.766433314748569,"TRPV5","transient receptor potential cation channel subfamily V member 5",TRUE
+"1555042_at",0.904432955312383,0.608170736919498,0.520072592278179,-5.80879659896408,0.178775366570328,"TRPV5","transient receptor potential cation channel subfamily V member 5",TRUE
+"1559405_a_at",0.868397087637799,0.504289652171553,0.678806635332193,-5.71771329507514,0.409449965554758,"TRPV6","transient receptor potential cation channel subfamily V member 6",TRUE
+"206827_s_at",0.998870448604467,0.995654602592784,-0.00550795402346699,-5.93966870445417,-0.00591204865366635,"TRPV6","transient receptor potential cation channel subfamily V member 6",TRUE
+"202642_s_at",0.920119557710459,0.659880392208307,-0.446062983473944,-5.84323339688436,-0.153763664889631,"TRRAP","transformation/transcription domain associated protein",TRUE
+"214908_s_at",0.97689149311934,0.890072161294492,0.139811382432758,-5.93016723166172,0.0444671263464702,"TRRAP","transformation/transcription domain associated protein",TRUE
+"241605_at",0.698445705579474,0.169667580804863,1.4195088363485,-5.00319049217191,1.01166245512173,"TRUB1","TruB pseudouridine synthase family member 1",TRUE
+"241606_s_at",0.728385463227073,0.20875091339381,-1.2947096495485,-5.15463391210603,-0.448343181095359,"TRUB1","TruB pseudouridine synthase family member 1",TRUE
+"235447_at",0.754682106570676,0.248303180888887,-1.18569548995086,-5.27719318419629,-0.478920242028187,"TRUB1","TruB pseudouridine synthase family member 1",TRUE
+"226339_at",0.839977781712505,0.428812360765508,-0.80599424884626,-5.62813271392822,-0.290272449378604,"TRUB1","TruB pseudouridine synthase family member 1",TRUE
+"236020_s_at",0.97689149311934,0.889826368108694,0.140126137388371,-5.93012435617959,0.100832303130217,"TRUB1","TruB pseudouridine synthase family member 1",TRUE
+"223109_at",0.752155597823425,0.245325848669138,-1.19342389568266,-5.26881163755186,-0.424832620645478,"TRUB2","TruB pseudouridine synthase family member 2",TRUE
+"1568828_at",0.709914655587487,0.182726557740234,-1.37549325701612,-5.05792809047279,-0.681262781176648,"TRY2P","trypsinogen-like pseudogene",TRUE
+"230608_at",0.741771908548523,0.232279411911463,1.22814548632971,-5.23057284506091,0.552763449100202,"TSACC","TSSK6 activating cochaperone",TRUE
+"209390_at",0.499428826990278,0.0315414309940088,-2.29539442333663,-3.65518585957915,-0.581445155812469,"TSC1","tuberous sclerosis 1",TRUE
+"215735_s_at",0.498206796273596,0.0311395280371775,-2.30145289795465,-3.64440731673482,-0.960948008825678,"TSC2","tuberous sclerosis 2",TRUE
+"215624_at",0.854184492233394,0.464515019132937,-0.744302224882239,-5.6734006227098,-0.486462186329873,"TSC2","tuberous sclerosis 2",TRUE
+"239123_at",0.642592458809121,0.112697032665713,-1.65170978351248,-4.6916714716033,-1.27072318939047,"TSC22D1","TSC22 domain family member 1",TRUE
+"235315_at",0.787784580458053,0.313672982470449,1.03098131622965,-5.43482358606399,0.552534526184889,"TSC22D1","TSC22 domain family member 1",TRUE
+"243133_at",0.812302873476553,0.357161913903225,-0.94038167160916,-5.51790609176615,-0.537390291225723,"TSC22D1","TSC22 domain family member 1",TRUE
+"215111_s_at",0.817055852876968,0.369415457076178,-0.916222366589773,-5.5388795150449,-0.370044517397705,"TSC22D1","TSC22 domain family member 1",TRUE
+"229990_at",0.726636642789909,0.206031934804693,-1.30276882438089,-5.14520799216567,-0.62624163849349,"TSC22D1-AS1","TSC22D1 antisense RNA 1",TRUE
+"237745_at",0.908245165368208,0.618869202300733,-0.504530971611947,-5.81645561063874,-0.252961795676804,"TSC22D1-AS1","TSC22D1 antisense RNA 1",TRUE
+"204094_s_at",0.666643938027574,0.133556926821869,1.55735108054397,-4.8227567306541,0.488798482269981,"TSC22D2","TSC22 domain family member 2",TRUE
+"210953_at",0.75017710842651,0.243077746095367,1.19930611882816,-5.26240053469871,0.525969590354088,"TSC22D2","TSC22 domain family member 2",TRUE
+"215547_at",0.774230543658252,0.287395754167129,1.0900706152873,-5.37693009836972,0.589916955058743,"TSC22D2","TSC22 domain family member 2",TRUE
+"210954_s_at",0.778153753138113,0.297544079613422,1.06681090841312,-5.40006399687273,0.404782570031995,"TSC22D2","TSC22 domain family member 2",TRUE
+"238932_at",0.962125056232529,0.827987382364811,-0.219867564297587,-5.91616538952287,-0.1501088278431,"TSC22D2","TSC22 domain family member 2",TRUE
+"240557_at",0.99925604280637,0.997547525229711,0.00310859246397807,-5.93967877409011,0.00134642856631917,"TSC22D2","TSC22 domain family member 2",TRUE
+"207001_x_at",0.412521543656754,0.0165234966732198,-2.59360319580725,-3.10630946695835,-1.91177389550576,"TSC22D3","TSC22 domain family member 3",TRUE
+"208763_s_at",0.494430668301365,0.0300592142923409,-2.31810066768177,-3.6147045997508,-1.91666958408955,"TSC22D3","TSC22 domain family member 3",TRUE
+"235364_at",0.710824498521146,0.18405009356478,1.37117327740058,-5.06322337941356,0.573458918737826,"TSC22D3","TSC22 domain family member 3",TRUE
+"208104_s_at",0.596382916302699,0.0729049918781999,-1.88293434429319,-4.34625333228919,-0.68427502129813,"TSC22D4","TSC22 domain family member 4",TRUE
+"1554501_at",0.954268167568204,0.789664544553376,0.269992833355397,-5.90424070034773,0.0878194837881443,"TSC22D4","TSC22 domain family member 4",TRUE
+"230257_s_at",0.769258076576208,0.275744124030003,-1.11751863597445,-5.34905964425035,-0.396274563186674,"TSEN15","tRNA splicing endonuclease subunit 15",TRUE
+"225399_at",0.851650449893991,0.45568702802453,-0.759281197053245,-5.66272231682785,-0.219155602284427,"TSEN15","tRNA splicing endonuclease subunit 15",TRUE
+"225400_at",0.9181984176728,0.652714178376392,-0.45616070133275,-5.83883918845603,-0.135808787772914,"TSEN15","tRNA splicing endonuclease subunit 15",TRUE
+"1556279_at",0.782471668844017,0.304769005149945,1.05059502220029,-5.4159277765848,0.344934469275786,"TSEN2","tRNA splicing endonuclease subunit 2",TRUE
+"244391_at",0.878278790222455,0.531080943448877,0.636329474286477,-5.74436550666266,0.214120471795147,"TSEN2","tRNA splicing endonuclease subunit 2",TRUE
+"219581_at",0.913627134030439,0.637960027354462,0.477104460866981,-5.82941800094536,0.158718232724187,"TSEN2","tRNA splicing endonuclease subunit 2",TRUE
+"218132_s_at",0.766390367856479,0.266792364599751,-1.13918630355766,-5.32662531821335,-0.325395786446832,"TSEN34","tRNA splicing endonuclease subunit 34",TRUE
+"1558304_s_at",0.597707642267173,0.075105512614425,-1.8675805225991,-4.37020069677431,-0.573365454156802,"TSEN54","tRNA splicing endonuclease subunit 54",TRUE
+"225879_at",0.620702528691386,0.0903779210043369,-1.77064831790118,-4.51813534638616,-0.798051397216652,"TSEN54","tRNA splicing endonuclease subunit 54",TRUE
+"241402_at",0.948549918396036,0.765918277043406,-0.30140232293832,-5.89553363231592,-0.245775914436447,"TSEN54","tRNA splicing endonuclease subunit 54",TRUE
+"214331_at",0.61760967235709,0.0880577667945185,-1.78441415256472,-4.49747432402708,-1.38278565146184,"TSFM","Ts translation elongation factor, mitochondrial",TRUE
+"212656_at",0.658269224872653,0.126621260868508,-1.58726846272273,-4.7818443628026,-0.764030502750986,"TSFM","Ts translation elongation factor, mitochondrial",TRUE
+"214332_s_at",0.812896635201594,0.361809655735255,-0.931153761063866,-5.52597636883191,-0.498525263249338,"TSFM","Ts translation elongation factor, mitochondrial",TRUE
+"201758_at",0.904598219218042,0.608541876562575,-0.51953128370414,-5.80906716567501,-0.153444884627207,"TSG101","tumor susceptibility 101",TRUE
+"223838_at",0.740204718718397,0.228539476116786,-1.23837042714639,-5.21913153060227,-0.667334885691151,"TSGA10","testis specific 10",TRUE
+"220623_s_at",0.937842878751575,0.724899450719814,-0.356417637570899,-5.87799882909997,-0.262917321663935,"TSGA10","testis specific 10",TRUE
+"1555931_at",0.975159323713639,0.87901795551956,-0.153981863394811,-5.92814160634879,-0.109572055186015,"TSGA10","testis specific 10",TRUE
+"1555932_at",0.98427503418599,0.923578867982095,-0.0970249817787813,-5.93509938284762,-0.0871673168118217,"TSGA10","testis specific 10",TRUE
+"1553483_at",0.914242258486146,0.639455434387768,-0.474971976120769,-5.83039618833154,-0.391186565508356,"TSGA10IP","testis specific 10 interacting protein",TRUE
+"1553641_a_at",0.559388432054223,0.0538750273450452,2.03603648874126,-4.10012318740825,0.987490971792544,"TSGA13","testis specific 13",TRUE
+"214529_at",0.54756909892274,0.0480167051202235,2.09295612101507,-4.00536150452642,0.523771794122767,"TSHB","thyroid stimulating hormone beta",TRUE
+"215443_at",0.565795244949651,0.0567163710214116,2.01039643166198,-4.14224737040453,1.1542417907178,"TSHR","thyroid stimulating hormone receptor",TRUE
+"210055_at",0.903383391791809,0.603412369375129,-0.527026722319202,-5.80529625205324,-0.23574219895045,"TSHR","thyroid stimulating hormone receptor",TRUE
+"215442_s_at",0.98453870130544,0.924635824255377,0.0956787431931645,-5.93522568277378,0.0827957868267277,"TSHR","thyroid stimulating hormone receptor",TRUE
+"223282_at",0.364513221153898,0.0106594268973037,-2.78883060533594,-2.72905808640529,-1.29034664329587,"TSHZ1","teashirt zinc finger homeobox 1",TRUE
+"223283_s_at",0.446042644461835,0.0208928251022727,-2.48696880624171,-3.30668490587753,-1.25090911290821,"TSHZ1","teashirt zinc finger homeobox 1",TRUE
+"235616_at",0.580748061056528,0.0634866238854114,1.95361972727393,-4.23424844495063,1.3705422184081,"TSHZ2","teashirt zinc finger homeobox 2",TRUE
+"220213_at",0.585036027492332,0.0655943590324431,1.93703655924314,-4.26078123012603,1.26148414693156,"TSHZ2","teashirt zinc finger homeobox 2",TRUE
+"244521_at",0.604395008363632,0.0785964515790333,1.84400950687684,-4.40669400389903,1.51228696684203,"TSHZ2","teashirt zinc finger homeobox 2",TRUE
+"238577_s_at",0.70573152022539,0.177807275469964,-1.39177039846089,-5.03785198430007,-0.986654868747938,"TSHZ2","teashirt zinc finger homeobox 2",TRUE
+"243940_at",0.71454754703986,0.189679630467367,-1.35306843277902,-5.08526462381771,-1.02305087087843,"TSHZ2","teashirt zinc finger homeobox 2",TRUE
+"235815_at",0.865218946549899,0.494508035861688,-0.694629044786257,-5.7073644718971,-0.211049051146401,"TSHZ2","teashirt zinc finger homeobox 2",TRUE
+"223392_s_at",0.91202803207519,0.631274921295897,-0.486665256652137,-5.82497971706783,-0.207692346757621,"TSHZ3","teashirt zinc finger homeobox 3",TRUE
+"223393_s_at",0.916340239998123,0.646558276701373,-0.464873396847339,-5.83497023355102,-0.39552844227792,"TSHZ3","teashirt zinc finger homeobox 3",TRUE
+"231592_at",0.903615659612912,0.605028064372254,0.524662526170661,-5.80649134513446,0.446394754920317,"TSIX","TSIX transcript, XIST antisense RNA",TRUE
+"220544_at",0.675447258877226,0.141654885691809,1.52400367642958,-4.86763496417883,0.93412220858008,"TSKS","testis specific serine kinase substrate",TRUE
+"220545_s_at",0.787781415608703,0.313599680122971,1.03114117349143,-5.43467087670858,0.465417156473201,"TSKS","testis specific serine kinase substrate",TRUE
+"218245_at",0.986342822130003,0.933836717422961,-0.0839669934900103,-5.93625004693933,-0.0551649676767472,"TSKU","tsukushi, small leucine rich proteoglycan",TRUE
+"235737_at",0.115775110300518,0.000620431775364458,3.98384594745943,-0.235525310605314,3.50757452791376,"TSLP","thymic stromal lymphopoietin",TRUE
+"201515_s_at",0.446963972064621,0.021126092175389,-2.48188094144597,-3.31613654474166,-0.721257812931457,"TSN","translin",TRUE
+"201513_at",0.895366192695711,0.573679307225738,-0.571100368157948,-5.78206158599563,-0.22078877635888,"TSN","translin",TRUE
+"201504_s_at",0.944850801239076,0.751999090825006,-0.319956253019377,-5.8899444874998,-0.139843390552983,"TSN","translin",TRUE
+"231317_at",0.715549750539287,0.191274124460868,1.34801753322963,-5.0913700238084,1.27436168246088,"TSNARE1","t-SNARE domain containing 1",TRUE
+"228862_at",0.744573608322482,0.235899410620252,-1.21836670725343,-5.24143826992169,-0.796679605957034,"TSNARE1","t-SNARE domain containing 1",TRUE
+"1552799_at",0.944705930911859,0.751334933271336,0.320844376721968,-5.88966866007506,0.127645182292876,"TSNARE1","t-SNARE domain containing 1",TRUE
+"203983_at",0.663819586595936,0.131938316370152,-1.56421577559908,-4.81342321450317,-0.672760780583028,"TSNAX","translin associated factor X",TRUE
+"206090_s_at",0.940668681806864,0.734534298349808,-0.343400476923973,-5.88240975282969,-0.246044226504468,"TSNAX-DISC1///DISC1","TSNAX-DISC1 readthrough (NMD candidate)///disrupted in schizophrenia 1",TRUE
+"207759_s_at",0.998131719304097,0.991468379979982,-0.0108143111813027,-5.93962651920465,-0.00488365017385295,"TSNAX-DISC1///DISC1","TSNAX-DISC1 readthrough (NMD candidate)///disrupted in schizophrenia 1",TRUE
+"222220_s_at",0.945272089973488,0.752855208825571,-0.318811823374354,-5.89029880035132,-0.0801955889169745,"TSNAXIP1","translin associated factor X interacting protein 1",TRUE
+"209114_at",0.826140850652187,0.394298075304647,0.868748239577037,-5.57862285437334,1.20438668669977,"TSPAN1","tetraspanin 1",TRUE
+"223795_at",0.777463110382572,0.296391687716917,1.06942326104815,-5.39748800940006,0.715831573772819,"TSPAN10","tetraspanin 10",TRUE
+"1560464_at",0.904540796040532,0.608470861288371,-0.51963484758533,-5.80901542172518,-0.37594862170311,"TSPAN10","tetraspanin 10",TRUE
+"227610_at",0.908351966956255,0.619069494978675,0.504241216344828,-5.81659625193748,0.305724027824265,"TSPAN11","tetraspanin 11",TRUE
+"219274_at",0.876763265334889,0.525782327650464,0.644635021084763,-5.73928417928722,0.661026233400223,"TSPAN12","tetraspanin 12",TRUE
+"230625_s_at",0.941345931827527,0.737693786940002,0.339145097248069,-5.88381652308576,0.441331673833908,"TSPAN12","tetraspanin 12",TRUE
+"230626_at",0.97814499039687,0.893971745224172,0.134819611517313,-5.93083433756334,0.0816943013492821,"TSPAN12","tetraspanin 12",TRUE
+"217979_at",0.89316156038085,0.567205872355149,-0.580846340414659,-5.77667955170279,-0.434327539977843,"TSPAN13","tetraspanin 13",TRUE
+"221002_s_at",0.943824539742785,0.748614413499804,-0.324485063992725,-5.88853004876017,-0.129351308232142,"TSPAN14","tetraspanin 14",TRUE
+"223314_at",0.953404125808695,0.785361398709101,0.275663181169769,-5.90273908717613,0.0939574254920874,"TSPAN14","tetraspanin 14",TRUE
+"218693_at",0.841420204214686,0.432427610169109,-0.799607564192822,-5.63297654085607,-0.627466221680269,"TSPAN15","tetraspanin 15",TRUE
+"242180_at",0.65668125311818,0.124694371648339,1.59582155651605,-4.77003609446481,1.26069698225478,"TSPAN16","tetraspanin 16",TRUE
+"233236_at",0.672310118804972,0.138103883516217,1.53842809168496,-4.84831734062296,0.928559964504749,"TSPAN16","tetraspanin 16",TRUE
+"242179_s_at",0.989586772349659,0.949354180588329,0.0642412829327488,-5.93767359914078,0.0300633461272835,"TSPAN16","tetraspanin 16",TRUE
+"225235_at",0.794090864301234,0.325856838252629,-1.00476673242888,-5.45957637260861,-0.327102617006281,"TSPAN17","tetraspanin 17",TRUE
+"1558119_at",0.991215113882097,0.958721665344129,0.0523465328796191,-5.93834893820976,0.0179838195609738,"TSPAN17","tetraspanin 17",TRUE
+"228819_at",0.954387719376857,0.790239407163135,-0.269236012924155,-5.90443877638009,-0.187770729177085,"TSPAN18","tetraspanin 18",TRUE
+"227307_at",0.955730092376044,0.797761498964022,0.259347608138526,-5.90697603480093,0.136837139293015,"TSPAN18","tetraspanin 18",TRUE
+"227236_at",0.0808717557112272,0.00027955668640918,4.30937030579174,0.467536231943277,3.07789177285173,"TSPAN2","tetraspanin 2",TRUE
+"227233_at",0.29806620002593,0.00546969962390506,3.07806915285986,-2.14932013816447,2.8341413140745,"TSPAN2","tetraspanin 2",TRUE
+"214606_at",0.34698307261505,0.00897538828901183,2.86419264346871,-2.58020035106733,3.68114259986704,"TSPAN2","tetraspanin 2",TRUE
+"200973_s_at",0.90998880119877,0.625331626020873,0.495203915413232,-5.82094318244379,0.403045432383689,"TSPAN3","tetraspanin 3",TRUE
+"1558786_at",0.912457981072444,0.633338461485126,0.483709186443768,-5.82636116996438,0.4845694389528,"TSPAN3","tetraspanin 3",TRUE
+"1558787_a_at",0.920734496427305,0.662767095913335,-0.442008739981258,-5.84497052950744,-0.219256544961943,"TSPAN3","tetraspanin 3",TRUE
+"230282_at",0.927552865877291,0.68252463544497,0.414456950104974,-5.85636298428011,0.208425814222533,"TSPAN3","tetraspanin 3",TRUE
+"200972_at",0.929708688071902,0.689965427109383,0.404165937309482,-5.86043333806113,0.266809120220262,"TSPAN3","tetraspanin 3",TRUE
+"203226_s_at",0.819018525257656,0.375017735307331,-0.905354458648254,-5.54815020738695,-0.453729677698467,"TSPAN31","tetraspanin 31",TRUE
+"203227_s_at",0.85334340854827,0.46065549303491,-0.750829779653454,-5.66877198366848,-0.496000674828096,"TSPAN31","tetraspanin 31",TRUE
+"220558_x_at",0.48580305784244,0.028342124763095,-2.34572736615204,-3.56514186106547,-0.896783779431033,"TSPAN32","tetraspanin 32",TRUE
+"233467_s_at",0.863488263044072,0.488199440474235,0.704928538794857,-5.70050570714567,0.293985267252798,"TSPAN32","tetraspanin 32",TRUE
+"225775_at",0.967701855457407,0.848209344806074,0.193656362629286,-5.92143374635528,0.13086195739718,"TSPAN33","tetraspanin 33",TRUE
+"209264_s_at",0.816358096928248,0.367428651835887,-0.920102850837157,-5.53554462064797,-0.507293643035659,"TSPAN4","tetraspanin 4",TRUE
+"209263_x_at",0.861659105448003,0.483008033323443,-0.713461760752786,-5.69475029790254,-0.365694223381254,"TSPAN4","tetraspanin 4",TRUE
+"225388_at",0.976371465776674,0.886818910587436,-0.14397857621288,-5.9295917856228,-0.116230349649134,"TSPAN5","tetraspanin 5",TRUE
+"225387_at",0.990810941805126,0.953612164377394,0.0588334606886516,-5.93799771269118,0.0735248121503549,"TSPAN5","tetraspanin 5",TRUE
+"209890_at",0.990810941805126,0.955289196884269,0.0567040599696312,-5.9381175234504,0.0616350479860781,"TSPAN5","tetraspanin 5",TRUE
+"209108_at",0.646767005028134,0.117895430031539,1.62690976826716,-4.72670185755416,1.24665745599821,"TSPAN6","tetraspanin 6",TRUE
+"209109_s_at",0.663561605222859,0.131489350449668,1.56613223168193,-4.81081175905686,1.26002823970471,"TSPAN6","tetraspanin 6",TRUE
+"202242_at",0.83242103542195,0.408697032919375,0.842160030590038,-5.60002276623212,0.531847518045382,"TSPAN7","tetraspanin 7",TRUE
+"203824_at",0.93919895813272,0.727941287972458,0.352301287763851,-5.87941120380514,0.456086800090601,"TSPAN8","tetraspanin 8",TRUE
+"220968_s_at",0.493519901382617,0.0298173415720107,-2.32190308613066,-3.60790301734426,-1.09012582832202,"TSPAN9","tetraspanin 9",TRUE
+"205665_at",0.687949239097856,0.157284326417244,-1.46383031481536,-4.94664628377717,-0.981209763152965,"TSPAN9","tetraspanin 9",TRUE
+"1552570_at",0.631360647647282,0.102719047979754,1.70214704713668,-4.61918611095503,1.57609301569466,"TSPEAR","thrombospondin type laminin G domain and EAR repeats",TRUE
+"1555048_a_at",0.931370027472813,0.696496952266487,0.395168981333443,-5.86390931472049,0.285995733162113,"TSPEAR","thrombospondin type laminin G domain and EAR repeats",TRUE
+"1555049_at",0.994943851647199,0.976165084381439,-0.0302162937329647,-5.93923879000784,-0.0209274352793614,"TSPEAR","thrombospondin type laminin G domain and EAR repeats",TRUE
+"1554953_a_at",0.614411830126793,0.0853406898533268,1.80093805684253,-4.47251985543544,1.06126344149672,"TSPEAR-AS2","TSPEAR antisense RNA 2",TRUE
+"1554954_at",0.761748280722165,0.261186205982588,1.15302930794609,-5.31209377559289,0.837549505668933,"TSPEAR-AS2","TSPEAR antisense RNA 2",TRUE
+"202096_s_at",0.677807216574022,0.145171768110966,1.51000754829986,-4.88624040413059,0.691646426452673,"TSPO","translocator protein",TRUE
+"215449_at",0.76170660994474,0.260854038675909,1.15385636544179,-5.31122069531701,0.674271239349237,"TSPO2","translocator protein 2",TRUE
+"205839_s_at",0.817055852876968,0.369502021366912,0.916053611306215,-5.53902424884522,0.648055927781819,"TSPOAP1","TSPO associated protein 1",TRUE
+"228826_at",0.789795896476304,0.318063561681342,1.02145384457322,-5.44388644340136,0.295640229697743,"TSPOAP1-AS1","TSPOAP1 antisense RNA 1",TRUE
+"228828_at",0.964645095638491,0.836343328185668,-0.209018761776674,-5.918426631196,-0.184876738036434,"TSPOAP1-AS1","TSPOAP1 antisense RNA 1",TRUE
+"217162_at",0.398650588126476,0.0139839382973894,2.66849636067359,-2.96309946303341,1.19873879684765,"TSPY1","testis specific protein, Y-linked 1",TRUE
+"217160_at",0.943464796017993,0.746563632222548,0.327232443268404,-5.88766239688595,0.150944928338547,"TSPY1","testis specific protein, Y-linked 1",TRUE
+"207918_s_at",0.801837936177267,0.339375065040295,0.976466180708893,-5.48564907345792,0.470245129976917,"TSPY10///TSPY8///TSPY4///TSPY3///TSPY1","testis specific protein, Y-linked 10///testis specific protein, Y-linked 8///testis specific protein, Y-linked 4///testis specific protein, Y-linked 3///testis specific protein, Y-linked 1",TRUE
+"236369_at",0.632216562924782,0.10317874503932,1.69973399593795,-4.62269148563192,1.0688004464692,"TSPY26P","testis specific protein, Y-linked 26, pseudogene",TRUE
+"233617_at",0.740681080735184,0.231012195216531,-1.23159594153908,-5.22672106411998,-0.832704662524284,"TSPY26P","testis specific protein, Y-linked 26, pseudogene",TRUE
+"1560647_at",0.937856707467078,0.725102530929954,0.356142625574881,-5.87809369465089,0.176851085292006,"TSPYL1","TSPY like 1",TRUE
+"1560648_s_at",0.96287357728432,0.831411358644214,-0.215418913396769,-5.91710640789525,-0.104496270846112,"TSPYL1","TSPY like 1",TRUE
+"221493_at",0.994943851647199,0.976252023536649,-0.0301060432816948,-5.93924202911077,-0.0111282007006146,"TSPYL1","TSPY like 1",TRUE
+"218012_at",0.976433695486417,0.888160475068593,0.142259810971031,-5.9298311729195,0.0594725052829439,"TSPYL2","TSPY like 2",TRUE
+"212928_at",0.768852835478002,0.272814862567704,-1.12455147901484,-5.34181970090974,-0.533654380436376,"TSPYL4","TSPY like 4",TRUE
+"213122_at",0.697412165374288,0.16794016587687,1.42553196222872,-4.99558979626032,2.79987210661988,"TSPYL5","TSPY like 5",TRUE
+"231339_at",0.675622576285316,0.142093556596197,-1.52224244854556,-4.8699837396088,-1.36120775788499,"TSPYL6","TSPY like 6",TRUE
+"239042_at",0.412728274083545,0.0165442334792861,2.59303744166433,-3.10738373459043,0.94072962993161,"TSR1","TSR1, ribosome maturation factor",TRUE
+"218156_s_at",0.462759346061633,0.0234447807698349,2.43396570554534,-3.40464091706032,1.0856727246272,"TSR1","TSR1, ribosome maturation factor",TRUE
+"221987_s_at",0.561084367279569,0.0546526868766604,2.02890145340199,-4.11188089373771,0.836534431239453,"TSR1","TSR1, ribosome maturation factor",TRUE
+"218155_x_at",0.637812558837132,0.109120496712151,1.66933774765484,-4.66652563995408,0.571628053919413,"TSR1","TSR1, ribosome maturation factor",TRUE
+"213079_at",0.710672261019989,0.183721737268351,-1.37224272244379,-5.06191377917091,-0.400293222409328,"TSR2","TSR2, ribosome maturation factor",TRUE
+"214067_at",0.834454640870101,0.41280935462048,0.834676625021254,-5.60593396547149,0.492663147141771,"TSR3","TSR3, acp transferase ribosome maturation factor",TRUE
+"221993_s_at",0.867447813467579,0.499849138665834,-0.68596766879241,-5.71305776379313,-0.313919119293164,"TSR3","TSR3, acp transferase ribosome maturation factor",TRUE
+"213105_s_at",0.87106619978761,0.511438820202575,0.667351674990767,-5.72506318931014,0.186973658964819,"TSR3","TSR3, acp transferase ribosome maturation factor",TRUE
+"213104_at",0.9114480626414,0.629696422393257,0.488929464638329,-5.82391602693027,0.121891650491921,"TSR3","TSR3, acp transferase ribosome maturation factor",TRUE
+"217968_at",0.844169896707408,0.440751858262555,0.785026344526969,-5.64389944482258,0.255807001529922,"TSSC1","tumor suppressing subtransferable candidate 1",TRUE
+"218612_s_at",0.341170383079786,0.00851162912031191,-2.88731966531657,-2.53418939150924,-1.01390041866498,"TSSC4","tumor suppressing subtransferable candidate 4",TRUE
+"211694_at",0.937623890519979,0.723321601699795,-0.358555323248781,-5.87725896694981,-0.167120384827983,"TSSK1B","testis specific serine kinase 1B",TRUE
+"217275_at",0.620071773111622,0.0898097553044523,1.77399096921028,-4.51312915194347,0.781975293727783,"TSSK2","testis specific serine kinase 2",TRUE
+"214371_at",0.725143559947316,0.203218555437621,1.3111951954663,-5.13529962982344,1.0567556423217,"TSSK2","testis specific serine kinase 2",TRUE
+"32032_at",0.831875452294783,0.406815982940359,-0.845599036182205,-5.59728974889821,-0.309413927170482,"TSSK2///DGCR14","testis specific serine kinase 2///DiGeorge syndrome critical region gene 14",TRUE
+"239730_at",0.838245037296515,0.422906722380919,-0.816499582845077,-5.62008652584003,-0.609570968335738,"TSSK2///DGCR14","testis specific serine kinase 2///DiGeorge syndrome critical region gene 14",TRUE
+"204383_at",0.912457981072444,0.633314499383621,-0.483743487597309,-5.82634518727631,-0.150302814266039,"TSSK2///DGCR14","testis specific serine kinase 2///DiGeorge syndrome critical region gene 14",TRUE
+"217285_at",0.937842878751575,0.724961669973598,0.356333377044326,-5.87802790250467,0.195217901867824,"TSSK2///DGCR14","testis specific serine kinase 2///DiGeorge syndrome critical region gene 14",TRUE
+"216285_at",0.939442751103863,0.728712768624418,0.351258274132521,-5.87976650158473,0.200641876759295,"TSSK2///DGCR14","testis specific serine kinase 2///DiGeorge syndrome critical region gene 14",TRUE
+"1552395_at",0.918047479325634,0.652044586459119,0.45710665374555,-5.83842260029417,0.129879335876714,"TSSK3","testis specific serine kinase 3",TRUE
+"242595_at",0.844169896707408,0.440579460137472,0.785326601873111,-5.64367642831821,0.375164744190508,"TSSK4","testis specific serine kinase 4",TRUE
+"239524_at",0.710824498521146,0.184199348478675,1.37068765839494,-5.06381776882394,0.51746777097599,"TSSK6","testis specific serine kinase 6",TRUE
+"224409_s_at",0.945820394457833,0.75540362351708,0.315407751512077,-5.89134526143613,0.201172219658732,"TSSK6","testis specific serine kinase 6",TRUE
+"230989_s_at",0.988158789315145,0.943463468126734,-0.0717260136623117,-5.93717803614474,-0.046025084260493,"TSSK6","testis specific serine kinase 6",TRUE
+"209605_at",0.823933875444718,0.391220168935409,-0.874512517989097,-5.5739017906992,-0.469752066859991,"TST","thiosulfate sulfurtransferase",TRUE
+"36936_at",0.894729774938685,0.571875244530428,0.57381079433363,-5.78057365730918,0.280477944352739,"TSTA3","tissue specific transplantation antigen P35B",TRUE
+"201644_at",0.916790160854655,0.648285808779901,0.462424691037874,-5.83606484934685,0.255874341766972,"TSTA3","tissue specific transplantation antigen P35B",TRUE
+"226482_s_at",0.878788356961452,0.532024399170452,-0.634855343248487,-5.74526075881793,-0.555432629342347,"TSTD1","thiosulfate sulfurtransferase like domain containing 1",TRUE
+"1555430_at",0.791353982620776,0.32189350338474,1.01321788328244,-5.45165947857143,0.59032298442399,"TSTD2","thiosulfate sulfurtransferase like domain containing 2",TRUE
+"213161_at",0.881936082609925,0.538952874113632,-0.624072702385067,-5.75174838235345,-0.235819249198183,"TSTD2///TMOD1","thiosulfate sulfurtransferase like domain containing 2///tropomodulin 1",TRUE
+"230191_at",0.67818193964437,0.14555378843236,1.50850400150178,-4.88823095422565,0.462090941816481,"TTBK1","tau tubulin kinase 1",TRUE
+"240643_at",0.957571530817866,0.80854140362383,-0.245222203157073,-5.91043682979399,-0.151901905125728,"TTBK1","tau tubulin kinase 1",TRUE
+"213922_at",0.567292616148537,0.0574039949806569,2.00436343532402,-4.1521073557335,0.969028499539771,"TTBK2","tau tubulin kinase 2",TRUE
+"240011_at",0.670452734752167,0.136192194083871,1.54632035901799,-4.83768672580344,1.22871219261004,"TTBK2","tau tubulin kinase 2",TRUE
+"1554295_x_at",0.673582826047901,0.139823361806677,1.53140584300239,-4.85773980934003,1.45452317239772,"TTBK2","tau tubulin kinase 2",TRUE
+"226964_at",0.731548533938014,0.214979490772891,1.27654947486363,-5.17569148617139,0.475272365938942,"TTBK2","tau tubulin kinase 2",TRUE
+"231610_at",0.757479140651,0.253543134406782,1.17226043001225,-5.29165051129962,0.866072596956823,"TTBK2","tau tubulin kinase 2",TRUE
+"1554294_s_at",0.776978557113863,0.295844882875833,1.07066535169011,-5.3962612316719,0.876234605460941,"TTBK2","tau tubulin kinase 2",TRUE
+"1557073_s_at",0.814828191169275,0.365692805759701,0.923504631755882,-5.53261044574488,0.433651406348647,"TTBK2","tau tubulin kinase 2",TRUE
+"1554293_at",0.87538158011492,0.522643029049051,0.649577422949666,-5.73623038164942,0.518761399537487,"TTBK2","tau tubulin kinase 2",TRUE
+"201434_at",0.965992617204023,0.840817539574912,0.203220359842543,-5.91958849192932,0.062781736417044,"TTC1","tetratricopeptide repeat domain 1",TRUE
+"219587_at",0.380084968057051,0.0117857227847844,-2.74450979123453,-2.81579949959718,-2.4290692756559,"TTC12","tetratricopeptide repeat domain 12",TRUE
+"1554531_at",0.801086839730802,0.337498434757858,0.980347930814926,-5.48211301169699,0.358995415478824,"TTC12","tetratricopeptide repeat domain 12",TRUE
+"244571_s_at",0.940227139261806,0.732739161292243,-0.345821148039718,-5.88160177346922,-0.229402785293794,"TTC12","tetratricopeptide repeat domain 12",TRUE
+"215598_at",0.976371465776674,0.886849888140857,-0.143938883871542,-5.929597346283,-0.0530856608233901,"TTC12","tetratricopeptide repeat domain 12",TRUE
+"219481_at",0.749701891366977,0.242615041562448,-1.20052186256703,-5.26107206384705,-0.39683813595046,"TTC13","tetratricopeptide repeat domain 13",TRUE
+"225178_at",0.792716268502624,0.324358902340522,1.00795237491915,-5.45659917193202,0.559674705617464,"TTC14","tetratricopeptide repeat domain 14",TRUE
+"225180_at",0.837368340567858,0.420697730620352,0.820452635810165,-5.61703352802696,0.472301641037177,"TTC14","tetratricopeptide repeat domain 14",TRUE
+"241863_x_at",0.978428568803085,0.896217305061313,-0.131946719401077,-5.93120729843639,-0.0870962033909715,"TTC14","tetratricopeptide repeat domain 14",TRUE
+"236833_at",0.897949253801113,0.58660096929558,0.55181097696536,-5.79245342631433,0.29417095606817,"TTC16","tetratricopeptide repeat domain 16",TRUE
+"244416_at",0.620223198657182,0.0901767688313005,1.77182967154355,-4.51636685678872,0.605515219685393,"TTC17","tetratricopeptide repeat domain 17",TRUE
+"232323_s_at",0.64513208805899,0.116003433920861,-1.63582758751883,-4.71415215450557,-0.441578691565651,"TTC17","tetratricopeptide repeat domain 17",TRUE
+"224852_at",0.776955214137673,0.295730107913791,-1.07092627644017,-5.39600336176654,-0.273692498668517,"TTC17","tetratricopeptide repeat domain 17",TRUE
+"224849_at",0.830930599043131,0.404773764516045,-0.849344196781712,-5.59430160702999,-0.23058870735148,"TTC17","tetratricopeptide repeat domain 17",TRUE
+"232646_at",0.967098812766994,0.846589545069115,-0.195750552341185,-5.92103727482398,-0.0751421039015909,"TTC17","tetratricopeptide repeat domain 17",TRUE
+"218972_at",0.997352239065314,0.986573652049404,0.0170191677874839,-5.93954240288884,0.00699983697439066,"TTC17","tetratricopeptide repeat domain 17",TRUE
+"217964_at",0.793593431770853,0.325309761430889,1.00592901150068,-5.45849113315497,0.339787211849261,"TTC19","tetratricopeptide repeat domain 19",TRUE
+"230997_at",0.772417008567082,0.282718046190113,-1.10099129900208,-5.36591510932866,-0.84522283856878,"TTC21A","tetratricopeptide repeat domain 21A",TRUE
+"232308_at",0.87825462101175,0.530583544914331,-0.637107221267835,-5.74389236977449,-0.352289660695095,"TTC21A","tetratricopeptide repeat domain 21A",TRUE
+"235651_at",0.170937109535473,0.0014381540079802,3.63838808949704,-0.976865104943213,3.9359701445349,"TTC22","tetratricopeptide repeat domain 22",TRUE
+"220309_at",0.51531387545335,0.0355503132882989,2.23854851120903,-3.75550147359091,1.38609427012507,"TTC22","tetratricopeptide repeat domain 22",TRUE
+"215107_s_at",0.603702127972549,0.0783727584584345,1.84549228585437,-4.40440804263045,1.70439261024348,"TTC22","tetratricopeptide repeat domain 22",TRUE
+"215106_at",0.613829147339073,0.0848302338782632,1.80409295160668,-4.4677363425166,1.32620846743727,"TTC22","tetratricopeptide repeat domain 22",TRUE
+"1568821_at",0.64513208805899,0.116155331260772,1.63510713886122,-4.7151679726608,0.532722430483284,"TTC23","tetratricopeptide repeat domain 23",TRUE
+"232734_at",0.712148529314333,0.186259373512465,1.36401669531151,-5.07196516323511,1.32773386531856,"TTC23","tetratricopeptide repeat domain 23",TRUE
+"219838_at",0.734730148360473,0.219618475646832,1.26328564011139,-5.1909111126559,0.950293940167309,"TTC23","tetratricopeptide repeat domain 23",TRUE
+"240716_at",0.865376407374788,0.495215309262777,-0.693479045398105,-5.70812431568983,-0.398893990166235,"TTC23","tetratricopeptide repeat domain 23",TRUE
+"1557003_at",0.707898177720919,0.179567254036607,-1.38590628584138,-5.0451073003106,-0.447145544585357,"TTC23L","tetratricopeptide repeat domain 23 like",TRUE
+"239620_at",0.944428703061909,0.750602740975806,0.321823782961976,-5.88936360502801,0.228928255220342,"TTC23L","tetratricopeptide repeat domain 23 like",TRUE
+"223924_at",0.971867994936839,0.865327295531646,0.171577235244216,-5.92535511574293,0.158068369552701,"TTC25","tetratricopeptide repeat domain 25",TRUE
+"233999_s_at",0.775341201891078,0.291878049762959,1.07972577813554,-5.38727399900906,0.301706621322353,"TTC26","tetratricopeptide repeat domain 26",TRUE
+"1554672_at",0.916057757219214,0.645928636251352,0.465766603448432,-5.83456954475155,0.119809442780277,"TTC26","tetratricopeptide repeat domain 26",TRUE
+"235949_at",0.952613441433926,0.782951865657801,0.278842299127,-5.90188364386097,0.118972535105676,"TTC26","tetratricopeptide repeat domain 26",TRUE
+"219758_at",0.982909728377256,0.917244818893384,-0.105096560726034,-5.93430516018761,-0.036459591862652,"TTC26","tetratricopeptide repeat domain 26",TRUE
+"218710_at",0.592605015502039,0.0697740550515296,1.90549388078078,-4.31081793148828,0.654664942876083,"TTC27","tetratricopeptide repeat domain 27",TRUE
+"244248_at",0.819018525257656,0.373162135609666,0.908942170584387,-5.54510105642522,0.285953959790944,"TTC27","tetratricopeptide repeat domain 27",TRUE
+"234004_at",0.606900628956089,0.0802158614987992,1.83338308692444,-4.42303805721822,0.580229415793339,"TTC28","tetratricopeptide repeat domain 28",TRUE
+"215146_s_at",0.837337084923913,0.420013223263286,-0.821680222157687,-5.61608263463454,-0.833101542798183,"TTC28","tetratricopeptide repeat domain 28",TRUE
+"213058_at",0.936318756756998,0.715945962749233,-0.36857071985763,-5.87373441846073,-0.210302465394813,"TTC28","tetratricopeptide repeat domain 28",TRUE
+"1555871_at",0.564144814478888,0.0559965964001267,-2.01678156951196,-4.13179034854375,-1.40607069950267,"TTC28-AS1","TTC28 antisense RNA 1",TRUE
+"232246_at",0.790240875783718,0.31975222871641,1.01781401433087,-5.44732870428708,0.642763331387698,"TTC28-AS1","TTC28 antisense RNA 1",TRUE
+"244189_at",0.953564723226096,0.786309383569246,0.274413214630054,-5.90307276374631,0.1164511565645,"TTC28-AS1","TTC28 antisense RNA 1",TRUE
+"223962_at",0.93565329131222,0.713258316784008,-0.372229793724539,-5.8724228405625,-0.264270281452633,"TTC29","tetratricopeptide repeat domain 29",TRUE
+"213679_at",0.956084625435459,0.80137945222164,0.25460096877672,-5.90816046828122,0.157912428871024,"TTC30A","tetratricopeptide repeat domain 30A",TRUE
+"1554588_a_at",0.934781502857546,0.710341569212707,-0.376206643475355,-5.87098286019932,-0.194327866828572,"TTC30B","tetratricopeptide repeat domain 30B",TRUE
+"243413_at",0.994875434900261,0.975987813474994,0.0304410980908062,-5.93923214868702,0.0138630355448761,"TTC30B","tetratricopeptide repeat domain 30B",TRUE
+"218838_s_at",0.898204958706456,0.587270797692517,-0.550816869556706,-5.79297959596253,-0.148149012446495,"TTC31","tetratricopeptide repeat domain 31",TRUE
+"226838_at",0.696218893963034,0.166303040789341,-1.43128632465785,-4.98830362930691,-0.7248919006186,"TTC32","tetratricopeptide repeat domain 32",TRUE
+"219421_at",0.620437879410052,0.0903029376869056,1.77108842553512,-4.51747660510487,0.907769367634183,"TTC33","tetratricopeptide repeat domain 33",TRUE
+"231479_at",0.723655063748891,0.200660695958721,1.31893540874132,-5.12615052973876,0.738875842515804,"TTC33","tetratricopeptide repeat domain 33",TRUE
+"1565728_at",0.845724545411341,0.443643816862235,-0.780000241637653,-5.64762065530321,-0.45992978113371,"TTC34///LOC284630","tetratricopeptide repeat domain 34///uncharacterized LOC284630",TRUE
+"237350_at",0.789503009592599,0.316590204633146,-1.02464065566823,-5.44086349574604,-0.920685998837479,"TTC36","tetratricopeptide repeat domain 36",TRUE
+"203049_s_at",0.94632739401154,0.757161681939069,-0.313061623444083,-5.89206001844616,-0.119316489037457,"TTC37","tetratricopeptide repeat domain 37",TRUE
+"1554029_a_at",0.958264946445917,0.811267072795099,0.241658811273273,-5.91127945149246,0.108186143155622,"TTC37","tetratricopeptide repeat domain 37",TRUE
+"203048_s_at",0.996625121774816,0.983121266339483,0.02139602028084,-5.93946051073245,0.00807354543454508,"TTC37","tetratricopeptide repeat domain 37",TRUE
+"218272_at",0.823074246722209,0.389836957199412,-0.877112566448072,-5.57176280885689,-0.567332747542505,"TTC38","tetratricopeptide repeat domain 38",TRUE
+"216768_x_at",0.898197048519062,0.587247702409462,0.550851136440595,-5.792961474226,0.451339911631893,"TTC38","tetratricopeptide repeat domain 38",TRUE
+"216434_at",0.970161937857351,0.858310874248867,0.180615985527911,-5.92380692125779,0.0801414229619022,"TTC38","tetratricopeptide repeat domain 38",TRUE
+"210652_s_at",0.623503825356688,0.0942797638194026,-1.74816828981638,-4.55162262302964,-2.12457830194213,"TTC39A","tetratricopeptide repeat domain 39A",TRUE
+"217101_at",0.678126513742682,0.145445623263292,-1.50892938745709,-4.88766794535699,-1.43297114398777,"TTC39A","tetratricopeptide repeat domain 39A",TRUE
+"215562_at",0.912041701968169,0.63143267432165,-0.48643911672953,-5.82508568908602,-0.340733260313709,"TTC39A","tetratricopeptide repeat domain 39A",TRUE
+"232000_at",0.897949253801113,0.585934694884125,-0.552800367883184,-5.79192883834591,-0.447220453151285,"TTC39B","tetratricopeptide repeat domain 39B",TRUE
+"236826_at",0.913627134030439,0.637856264598542,0.477252512131315,-5.82934992953201,0.233845946358288,"TTC39B","tetratricopeptide repeat domain 39B",TRUE
+"242477_at",0.970135831114343,0.858221648032447,0.180731026825379,-5.92378670593563,0.14845464982363,"TTC39B","tetratricopeptide repeat domain 39B",TRUE
+"227881_s_at",0.518537987260825,0.0370980164710934,2.21815731695845,-3.79111848830553,1.04265272761754,"TTC39C","tetratricopeptide repeat domain 39C",TRUE
+"1552307_a_at",0.812302873476553,0.35924854876263,0.936228824924063,-5.52154701401279,0.365983659982783,"TTC39C","tetratricopeptide repeat domain 39C",TRUE
+"230747_s_at",0.88020017258149,0.535553533529325,0.629353636415113,-5.74858435129488,0.355608968752082,"TTC39C","tetratricopeptide repeat domain 39C",TRUE
+"238480_at",0.977128405459525,0.890898052348556,0.138753878300476,-5.93031057857985,0.0992586407854184,"TTC39C","tetratricopeptide repeat domain 39C",TRUE
+"208662_s_at",0.86679822545543,0.498140735451353,-0.68873233853931,-5.71124790537761,-0.23107290804518,"TTC3P1///TTC3","tetratricopeptide repeat domain 3 pseudogene 1///tetratricopeptide repeat domain 3",TRUE
+"1569472_s_at",0.898813992560978,0.588677489778619,-0.548730990103121,-5.79408063291951,-0.177480921124792,"TTC3P1///TTC3","tetratricopeptide repeat domain 3 pseudogene 1///tetratricopeptide repeat domain 3",TRUE
+"208663_s_at",0.9089753392553,0.621765225364092,-0.500345653358239,-5.81847942272472,-0.194287508971067,"TTC3P1///TTC3","tetratricopeptide repeat domain 3 pseudogene 1///tetratricopeptide repeat domain 3",TRUE
+"208073_x_at",0.92777930247318,0.683053918007859,-0.413723431428876,-5.85665644166004,-0.126535690201843,"TTC3P1///TTC3","tetratricopeptide repeat domain 3 pseudogene 1///tetratricopeptide repeat domain 3",TRUE
+"208661_s_at",0.946727564264032,0.758387931280215,-0.311426255955652,-5.89255511280115,-0.118116516213702,"TTC3P1///TTC3","tetratricopeptide repeat domain 3 pseudogene 1///tetratricopeptide repeat domain 3",TRUE
+"210645_s_at",0.948989397056643,0.76986920253139,-0.296155740668519,-5.89705409795991,-0.105558742491938,"TTC3P1///TTC3","tetratricopeptide repeat domain 3 pseudogene 1///tetratricopeptide repeat domain 3",TRUE
+"208664_s_at",0.950766293129613,0.775254922364964,-0.289017453877434,-5.89908026235388,-0.103275381947483,"TTC3P1///TTC3","tetratricopeptide repeat domain 3 pseudogene 1///tetratricopeptide repeat domain 3",TRUE
+"218442_at",0.933846357716735,0.706870879935341,0.380946837045523,-5.8692467625123,0.18066704439893,"TTC4","tetratricopeptide repeat domain 4",TRUE
+"1570008_at",0.724067243569133,0.201390260812845,1.31671990854973,-5.12877394435801,0.845639766386454,"TTC41P","tetratricopeptide repeat domain 41, pseudogene",TRUE
+"1570212_a_at",0.833956476774481,0.411784632445294,0.836536923808456,-5.60446910539361,0.521292929426591,"TTC41P","tetratricopeptide repeat domain 41, pseudogene",TRUE
+"1558606_s_at",0.687734660055697,0.156826137534365,1.46552355312937,-4.94445806191027,0.863814798158629,"TTC5","tetratricopeptide repeat domain 5",TRUE
+"226557_at",0.980123774502516,0.906553989947265,-0.118736585129899,-5.93281901338546,-0.0496514589548909,"TTC5","tetratricopeptide repeat domain 5",TRUE
+"243007_at",0.994050962712312,0.972208390673794,0.035234337690658,-5.93907883015019,0.0147339298758897,"TTC5","tetratricopeptide repeat domain 5",TRUE
+"1562299_at",0.630132423960255,0.101285350233787,1.70973227125261,-4.60814296012205,1.32543655174612,"TTC6","tetratricopeptide repeat domain 6",TRUE
+"1556666_a_at",0.646392036827936,0.117328724092691,-1.62956823299233,-4.72296622595609,-1.76223640330916,"TTC6","tetratricopeptide repeat domain 6",TRUE
+"1556665_at",0.659543761956192,0.127411337676341,-1.58379274680404,-4.78662873215756,-1.09014922708386,"TTC6","tetratricopeptide repeat domain 6",TRUE
+"224924_at",0.782311754252508,0.304508920153551,1.05117399662287,-5.415365128075,0.87941664146853,"TTC7A","tetratricopeptide repeat domain 7A",TRUE
+"240369_at",0.827564951695026,0.396396960658171,-0.864834139222314,-5.58181203939454,-0.25778693013789,"TTC7A","tetratricopeptide repeat domain 7A",TRUE
+"224923_at",0.834156464062358,0.4120359144935,0.836080470656538,-5.60482881370162,0.447653366293075,"TTC7A","tetratricopeptide repeat domain 7A",TRUE
+"224912_at",0.985031563903634,0.926105754586153,0.0938068026898745,-5.9353983721046,0.0590633511431058,"TTC7A","tetratricopeptide repeat domain 7A",TRUE
+"226152_at",0.967438733768155,0.84750641118049,-0.194565054696376,-5.92126223479818,-0.133660714102229,"TTC7B","tetratricopeptide repeat domain 7B",TRUE
+"226120_at",0.528235927681883,0.0408468313964348,-2.17180071389157,-3.87134742840704,-0.766133679406895,"TTC8","tetratricopeptide repeat domain 8",TRUE
+"213174_at",0.895060122261773,0.572560178803942,0.572781237973396,-5.78113965145824,0.479474477949532,"TTC9","tetratricopeptide repeat domain 9",TRUE
+"213172_at",0.910159094731364,0.62600453380945,-0.494235293207872,-5.82140453401831,-0.596027736831549,"TTC9","tetratricopeptide repeat domain 9",TRUE
+"235375_x_at",0.83872852514497,0.424104877409291,0.814360857204825,-5.62173253062941,0.205419804578313,"TTC9B","tetratricopeptide repeat domain 9B",TRUE
+"242484_at",0.992583835836326,0.965425071896479,-0.0438394566744119,-5.93874743846536,-0.0274810981404232,"TTC9B","tetratricopeptide repeat domain 9B",TRUE
+"226175_at",0.651336125611552,0.120939448508614,-1.61281053142624,-4.74643516982638,-0.406834753982441,"TTC9C","tetratricopeptide repeat domain 9C",TRUE
+"1569189_at",0.993807765450058,0.970596196790164,0.0372792476263251,-5.93900661118165,0.0174476992711652,"TTC9C","tetratricopeptide repeat domain 9C",TRUE
+"204772_s_at",0.821137675198948,0.382020596922353,-0.891919238034354,-5.55946957772713,-0.345311312688708,"TTF1","transcription termination factor 1",TRUE
+"204771_s_at",0.918409982899324,0.653734057356319,-0.454720699308244,-5.83947172731283,-0.147102512185146,"TTF1","transcription termination factor 1",TRUE
+"204407_at",0.968035667633768,0.849308751199595,-0.19223547885934,-5.9217003282981,-0.118542370718279,"TTF2","transcription termination factor 2",TRUE
+"1555307_at",0.99783553534859,0.989497113893721,0.0133131423093173,-5.93959715416637,0.00644284734141376,"TTF2","transcription termination factor 2",TRUE
+"212898_at",0.941397317345279,0.737828218434017,-0.338964179341645,-5.88387594764568,-0.0992073455039346,"TTI1","TELO2 interacting protein 1",TRUE
+"219124_at",0.922868429999087,0.669731569556539,-0.432258198594071,-5.84908461927232,-0.100317481510745,"TTI2","TELO2 interacting protein 2",TRUE
+"204822_at",0.545992239117952,0.0472435163237467,2.10092802502971,-3.99195471657215,0.870344386036352,"TTK","TTK protein kinase",TRUE
+"1559680_at",0.815977292327875,0.366954726360453,0.921030549678935,-5.53474543151596,0.680955987571081,"TTL","tubulin tyrosine ligase",TRUE
+"224908_s_at",0.92777930247318,0.683029423286379,-0.413757372916636,-5.85664287403776,-0.154087164607322,"TTL","tubulin tyrosine ligase",TRUE
+"1555374_at",0.968066640321622,0.849721492411104,0.19170215270074,-5.92179988443009,0.0662709706782856,"TTL","tubulin tyrosine ligase",TRUE
+"224896_s_at",0.986183732366864,0.932414848851809,-0.0857760515486957,-5.93610053393295,-0.0322709286287068,"TTL","tubulin tyrosine ligase",TRUE
+"205652_s_at",0.830643604139528,0.404527613121595,-0.84979642051818,-5.59393995908056,-0.413954898263784,"TTLL1","tubulin tyrosine ligase like 1",TRUE
+"1552418_at",0.912244494826693,0.632167137324361,0.485386597909425,-5.82557827918465,0.21419583895493,"TTLL10","tubulin tyrosine ligase like 10",TRUE
+"236418_at",0.929332398252332,0.689360258029064,-0.405001246561984,-5.86010670793544,-0.246599052897024,"TTLL10","tubulin tyrosine ligase like 10",TRUE
+"1552419_s_at",0.958931830316768,0.814038131495749,0.238039355281223,-5.91212277423412,0.0898243551064013,"TTLL10","tubulin tyrosine ligase like 10",TRUE
+"242545_at",0.506305427098933,0.0332443801241,-2.27048333496572,-3.6993295904677,-0.820106368549777,"TTLL11","tubulin tyrosine ligase like 11",TRUE
+"231157_at",0.562462825747979,0.0550606556149284,-2.02519444170753,-4.11797883625055,-0.730272049183135,"TTLL11","tubulin tyrosine ligase like 11",TRUE
+"228172_at",0.932633693661011,0.702592806208781,0.386802007048867,-5.86707271643196,0.248815928198066,"TTLL11","tubulin tyrosine ligase like 11",TRUE
+"216251_s_at",0.963407190044049,0.83317929158148,0.213123646066263,-5.91758443479491,0.0861542542866491,"TTLL12","tubulin tyrosine ligase like 12",TRUE
+"1552257_a_at",0.973615804712521,0.873071119624913,0.161618349363361,-5.92696915499684,0.0538337327742298,"TTLL12","tubulin tyrosine ligase like 12",TRUE
+"1568843_at",0.535243600695458,0.042709059669625,2.15018988773208,-3.90839024571168,1.26247051663548,"TTLL13P","tubulin tyrosine ligase like 13, pseudogene",TRUE
+"223998_at",0.659720905074258,0.127540008534703,1.58322839421895,-4.7874047978704,1.49222262077185,"TTLL2","tubulin tyrosine ligase like 2",TRUE
+"1555475_x_at",0.918141489589102,0.652398889128635,-0.456606067126175,-5.838643159095,-0.267097784573834,"TTLL3","tubulin tyrosine ligase like 3",TRUE
+"230873_at",0.945498722604777,0.754137902152956,0.317097974348538,-5.89082705296828,0.152172191288944,"TTLL3","tubulin tyrosine ligase like 3",TRUE
+"1555474_at",0.979588787486838,0.90156367674222,-0.125111283160394,-5.93206243740485,-0.0779948037236053,"TTLL3","tubulin tyrosine ligase like 3",TRUE
+"203703_s_at",0.657571067962164,0.126350629959321,1.58846317368178,-4.78019793662611,0.63451319443516,"TTLL4","tubulin tyrosine ligase like 4",TRUE
+"203702_s_at",0.687905784847237,0.157158320229115,1.4642955723113,-4.94604522204504,0.9276165986437,"TTLL4","tubulin tyrosine ligase like 4",TRUE
+"1557611_at",0.812302873476553,0.359515088167147,0.935699523558544,-5.52201000467884,0.324028822012309,"TTLL4","tubulin tyrosine ligase like 4",TRUE
+"1566101_at",0.689848451630875,0.158841419184258,-1.45810576027568,-4.95402909938829,-1.00772936191255,"TTLL5","tubulin tyrosine ligase like 5",TRUE
+"1566102_at",0.715966652952345,0.191618473390977,1.34693108607041,-5.09268079569426,0.625290593376037,"TTLL5","tubulin tyrosine ligase like 5",TRUE
+"208099_x_at",0.774230543658252,0.287766353170339,1.08921090947572,-5.37779307652997,0.412311793784061,"TTLL5","tubulin tyrosine ligase like 5",TRUE
+"210539_at",0.789661545166663,0.317349208534821,1.02299766637536,-5.44242306608521,0.64128663199407,"TTLL5","tubulin tyrosine ligase like 5",TRUE
+"215898_at",0.805746717966166,0.345613256274124,0.963667332708956,-5.49721742594897,0.585110315345237,"TTLL5","tubulin tyrosine ligase like 5",TRUE
+"210806_at",0.936456142259101,0.716304438270764,0.368083064571969,-5.8739082505472,0.324123359552025,"TTLL5","tubulin tyrosine ligase like 5",TRUE
+"214672_at",0.937623890519979,0.723401311753819,-0.358447290510079,-5.87729646238217,-0.110277457662381,"TTLL5","tubulin tyrosine ligase like 5",TRUE
+"230924_at",0.838245037296515,0.422917043508447,-0.816481143293126,-5.62010073457603,-0.431726345695578,"TTLL6","tubulin tyrosine ligase like 6",TRUE
+"235351_at",0.65284137151906,0.121867337085554,1.6085718080767,-4.75234171465206,1.27942702083944,"TTLL7","tubulin tyrosine ligase like 7",TRUE
+"219882_at",0.875938621758472,0.524175938181868,0.64716203869828,-5.73772559103705,0.648328110967022,"TTLL7","tubulin tyrosine ligase like 7",TRUE
+"228724_at",0.882059205223864,0.539502657778199,-0.623220284650066,-5.7522566953679,-0.511520078081868,"TTLL7","tubulin tyrosine ligase like 7",TRUE
+"1561682_at",0.84176002413858,0.433685106883443,0.797393832028028,-5.63464703965816,0.315624171928675,"TTLL7-IT1","TTLL7 intronic transcript 1",TRUE
+"234337_at",0.522403182336918,0.0381931424378567,2.20419131112536,-3.8153985480207,1.34728826085173,"TTLL9","tubulin tyrosine ligase like 9",TRUE
+"232357_at",0.790240875783718,0.31942324313693,-1.01852206836577,-5.446659953673,-0.620966587432132,"TTLL9","tubulin tyrosine ligase like 9",TRUE
+"234336_s_at",0.956398858120188,0.802445952496822,-0.253202899383802,-5.9085051850225,-0.0731879749306112,"TTLL9","tubulin tyrosine ligase like 9",TRUE
+"242771_at",0.76711764189372,0.268952059311984,1.13391058813581,-5.33212273744507,0.647716262988156,"TTN","titin",TRUE
+"1557994_at",0.771855357662161,0.28193577022969,1.10283035346193,-5.36405056819778,0.7093743422798,"TTN","titin",TRUE
+"244839_at",0.813838373616733,0.364712515713235,0.925430490951151,-5.53094489421018,0.825891420194956,"TTN","titin",TRUE
+"208195_at",0.8920930097751,0.56391791732485,-0.585818243506983,-5.77389995457074,-0.297586095017338,"TTN","titin",TRUE
+"241791_at",0.933400538871064,0.705399947032004,0.382958484269407,-5.86850351717271,0.199220023632511,"TTN","titin",TRUE
+"240793_at",0.964758017337751,0.83693529986917,0.208251173262402,-5.91858230677476,0.0667635900160208,"TTN","titin",TRUE
+"1556043_a_at",0.728385463227073,0.209265826007439,1.29319259760961,-5.15640268643797,0.813531584031874,"TTN-AS1","TTN antisense RNA 1",TRUE
+"242679_at",0.787475262684958,0.313319375664354,1.03175270207141,-5.43408649511947,0.499745760169414,"TTN-AS1","TTN antisense RNA 1",TRUE
+"210614_at",0.79037866404381,0.320112393901895,1.01703943821932,-5.44805980268307,0.609218950668948,"TTPA","alpha tocopherol transfer protein",TRUE
+"219633_at",0.82979599608837,0.401237693649823,0.855857567984977,-5.5890754799814,0.331004021999949,"TTPAL","alpha tocopherol transfer protein like",TRUE
+"228031_at",0.900774308374385,0.596452150400629,0.537246470334165,-5.80007005366369,0.285721136769302,"TTPAL","alpha tocopherol transfer protein like",TRUE
+"209660_at",0.748440891167983,0.241373023206029,1.2037938730145,-5.25749085476184,0.979592005113319,"TTR","transthyretin",TRUE
+"224293_at",0.82064687791745,0.381326194311478,0.893244204044529,-5.55836023330092,0.493067896998199,"TTTY10","testis-specific transcript, Y-linked 10 (non-protein coding)",TRUE
+"224174_at",0.877330487963663,0.526863634966601,0.642936388249754,-5.74032855254901,0.340026320562367,"TTTY11","testis-specific transcript, Y-linked 11 (non-protein coding)",TRUE
+"224195_at",0.769258076576208,0.275225258385387,1.11876038933838,-5.34778424695727,0.427326277043068,"TTTY12","testis-specific transcript, Y-linked 12 (non-protein coding)",TRUE
+"224292_at",0.87293859951272,0.517292641057227,0.658038637773687,-5.73095042840306,0.379288957349258,"TTTY13","testis-specific transcript, Y-linked 13 (non-protein coding)",TRUE
+"224003_at",0.910888708415045,0.628472456548695,-0.490686913423282,-5.82308707878877,-0.225353165346071,"TTTY14","testis-specific transcript, Y-linked 14 (non-protein coding)",TRUE
+"207063_at",0.986455005400648,0.936955220259402,-0.08000028664758,-5.9365667350776,-0.0446005245144128,"TTTY14","testis-specific transcript, Y-linked 14 (non-protein coding)",TRUE
+"214983_at",0.675447258877226,0.141756966549028,1.52359343085209,-4.86818226132975,0.658906516152958,"TTTY15","testis-specific transcript, Y-linked 15 (non-protein coding)",TRUE
+"216673_at",0.816800680706682,0.368961810165481,0.91710717180888,-5.53812025527153,0.464963611094261,"TTTY1B///TTTY1","testis-specific transcript, Y-linked 1B (non-protein coding)///testis-specific transcript, Y-linked 1 (non-protein coding)",TRUE
+"217261_at",0.833099102740246,0.410204371446609,-0.83941152139434,-5.60219956125488,-0.471119074559364,"TTTY2B///TTTY2","testis-specific transcript, Y-linked 2B (non-protein coding)///testis-specific transcript, Y-linked 2 (non-protein coding)",TRUE
+"234913_at",0.657571067962164,0.126305134272915,1.5886642252109,-4.77992077334351,1.34279408750093,"TTTY4C///TTTY4B///TTTY4","testis-specific transcript, Y-linked 4C (non-protein coding)///testis-specific transcript, Y-linked 4B (non-protein coding)///testis-specific transcript, Y-linked 4 (non-protein coding)",TRUE
+"224040_at",0.801086839730802,0.337348285155953,-0.98065915003117,-5.48182895454763,-0.562040859529477,"TTTY5","testis-specific transcript, Y-linked 5 (non-protein coding)",TRUE
+"224041_at",0.936143408699214,0.71490876058978,0.3699822002716,-5.87322999477356,0.253333873394338,"TTTY6B///TTTY6","testis-specific transcript, Y-linked 6B (non-protein coding)///testis-specific transcript, Y-linked 6 (non-protein coding)",TRUE
+"1561185_at",0.789267479986321,0.315562208189786,-1.02687033419289,-5.43874340946572,-0.36434658802109,"TTTY7","testis-specific transcript, Y-linked 7 (non-protein coding)",TRUE
+"233151_s_at",0.895657764833717,0.575145678439323,0.568900470266523,-5.78326423352598,0.373631660370156,"TTTY7B///TTTY7","testis-specific transcript, Y-linked 7B (non-protein coding)///testis-specific transcript, Y-linked 7 (non-protein coding)",TRUE
+"234309_at",0.923494952314901,0.671710564309697,-0.429495320962307,-5.85023398680207,-0.36171022001149,"TTTY7B///TTTY7","testis-specific transcript, Y-linked 7B (non-protein coding)///testis-specific transcript, Y-linked 7 (non-protein coding)",TRUE
+"224142_s_at",0.77547560202111,0.29268648540545,-1.07787214245131,-5.38911816615583,-0.471797806516515,"TTTY8B///TTTY8","testis-specific transcript, Y-linked 8B (non-protein coding)///testis-specific transcript, Y-linked 8 (non-protein coding)",TRUE
+"224143_at",0.896292432634083,0.580331932467841,0.56114248601977,-5.78746947496455,0.348952189234224,"TTTY8B///TTTY8","testis-specific transcript, Y-linked 8B (non-protein coding)///testis-specific transcript, Y-linked 8 (non-protein coding)",TRUE
+"211460_at",0.765228531154075,0.265144347820952,1.14323324607441,-5.32239306707497,0.354244578195957,"TTTY9B///TTTY9A","testis-specific transcript, Y-linked 9B (non-protein coding)///testis-specific transcript, Y-linked 9A (non-protein coding)",TRUE
+"219415_at",0.839519981963042,0.427458568316784,-0.808394456367152,-5.6263029786495,-0.872877479728039,"TTYH1","tweety family member 1",TRUE
+"223741_s_at",0.893342502624307,0.568030216803549,0.579602121352839,-5.77737155894493,0.569599619863231,"TTYH2","tweety family member 2",TRUE
+"232042_at",0.996771621728225,0.983700103616123,-0.0206621566375333,-5.93947554359936,-0.0134658457868984,"TTYH2","tweety family member 2",TRUE
+"224674_at",0.74371414757151,0.234487214381105,1.22216789475938,-5.23722360437401,0.697563019788525,"TTYH3","tweety family member 3",TRUE
+"210737_at",0.646692716816097,0.117580222819907,1.62838710557355,-4.72462650694112,0.852174321073637,"TUB","tubby bipartite transcription factor",TRUE
+"208431_s_at",0.71242055183987,0.186520962443949,1.36317377138138,-5.07299228739968,0.633826131446587,"TUB","tubby bipartite transcription factor",TRUE
+"228883_at",0.80443445759731,0.343151803466704,0.968698472333107,-5.4926866061313,0.587847658229622,"TUB","tubby bipartite transcription factor",TRUE
+"228882_at",0.85334340854827,0.460216255943571,-0.75157472004144,-5.66824131868832,-0.739849468900657,"TUB","tubby bipartite transcription factor",TRUE
+"209118_s_at",0.839466826665106,0.425519939296628,-0.811839807444954,-5.62366757985295,-1.15337286388502,"TUBA1A","tubulin alpha 1a",TRUE
+"1565668_at",0.822452640841017,0.387266967182487,0.881959395885553,-5.56775973804338,0.275308282715454,"TUBA1B","tubulin alpha 1b",TRUE
+"211058_x_at",0.933843132463653,0.706829819584696,0.381002969413149,-5.86922607557963,0.0842862564500066,"TUBA1B","tubulin alpha 1b",TRUE
+"212639_x_at",0.980475398877931,0.908981417628602,-0.11563759170762,-5.93317254498638,-0.0247514060179661,"TUBA1B","tubulin alpha 1b",TRUE
+"213646_x_at",0.981158705865426,0.911187899601354,0.112821677126461,-5.93348568633084,0.0244414894119132,"TUBA1B","tubulin alpha 1b",TRUE
+"201090_x_at",0.986889306520757,0.93926989242492,-0.0770568987822508,-5.93679182779641,-0.0168359669170162,"TUBA1B","tubulin alpha 1b",TRUE
+"211072_x_at",0.987240458855717,0.940456004737836,0.0755488842966423,-5.9369038850287,0.016316403262957,"TUBA1B","tubulin alpha 1b",TRUE
+"211750_x_at",0.953516309041226,0.785541334209723,0.275425892572061,-5.90280254675373,0.0634674216782667,"TUBA1C","tubulin alpha 1c",TRUE
+"209251_x_at",0.953931868692178,0.787484797042898,0.272863991485904,-5.90348423705771,0.0596654784514676,"TUBA1C","tubulin alpha 1c",TRUE
+"210527_x_at",0.914966942918905,0.641934127447813,0.471442212616253,-5.83200589536261,0.187099464272649,"TUBA3D///TUBA3C","tubulin alpha 3d///tubulin alpha 3c",TRUE
+"216323_x_at",0.918295771595924,0.653122598843161,0.455583921095542,-5.839092781713,0.190466168288234,"TUBA3D///TUBA3C","tubulin alpha 3d///tubulin alpha 3c",TRUE
+"1552698_at",0.565735799092003,0.056615768154597,2.01128453499446,-4.14079423518086,1.38713752888536,"TUBA3FP","tubulin alpha 3f pseudogene",TRUE
+"212242_at",0.5897618614591,0.0679610965900398,1.91896591799315,-4.2895165828632,1.41397135386609,"TUBA4A","tubulin alpha 4a",TRUE
+"207490_at",0.865885012497452,0.496253354582397,0.691792920211942,-5.70923622308448,0.222816557703968,"TUBA4B","tubulin alpha 4b",TRUE
+"220069_at",0.726636642789909,0.205818163539586,1.30340594299786,-5.14446071049656,0.9569586130133,"TUBA8","tubulin alpha 8",TRUE
+"220310_at",0.8115881531789,0.355807371407375,0.943086245745283,-5.51552696016713,0.381859988627285,"TUBAL3","tubulin alpha like 3",TRUE
+"212320_at",0.720174137377026,0.196227290518003,1.33253544837365,-5.10996506117054,0.355027962861213,"TUBB","tubulin beta class I",TRUE
+"209026_x_at",0.743553048228796,0.234042821041708,1.22336764490106,-5.23589099328875,0.337971205331245,"TUBB","tubulin beta class I",TRUE
+"211714_x_at",0.822850703882235,0.388601000506956,0.879440893979307,-5.5698423618463,0.209418926491137,"TUBB","tubulin beta class I",TRUE
+"208601_s_at",0.632216562924782,0.103153245588229,1.69986760863692,-4.62249748779462,1.16614768435592,"TUBB1","tubulin beta 1 class VI",TRUE
+"230690_at",0.944503488452294,0.750763078222431,0.321609282775651,-5.88943049399554,0.120358035667213,"TUBB1","tubulin beta 1 class VI",TRUE
+"204141_at",0.746259710622309,0.237728694170671,1.21346834178346,-5.24685270099641,0.787832754124144,"TUBB2A","tubulin beta 2A class IIa",TRUE
+"214023_x_at",0.695479865801506,0.164956248737338,1.43605441355583,-4.98224808933025,1.355148861561,"TUBB2B","tubulin beta 2B class IIb",TRUE
+"209372_x_at",0.91238586368984,0.633057305583768,0.484111691216562,-5.82617355231239,0.193851194149385,"TUBB2B///TUBB2A","tubulin beta 2B class IIb///tubulin beta 2A class IIa",TRUE
+"213476_x_at",0.716245563733659,0.192020489131203,1.34566463581822,-5.09420761947963,0.395520729587004,"TUBB3","tubulin beta 3 class III",TRUE
+"202154_x_at",0.903383391791809,0.603444368882193,-0.526979868955397,-5.80531998707777,-0.16127331900929,"TUBB3","tubulin beta 3 class III",TRUE
+"212664_at",0.658529993497593,0.126695509860104,1.58694105895934,-4.78229538778754,0.683046304131842,"TUBB4A","tubulin beta 4A class IVa",TRUE
+"213726_x_at",0.965354569120706,0.838374802910921,0.206385154054756,-5.91895837774913,0.044604628262304,"TUBB4B","tubulin beta 4B class IVb",TRUE
+"208977_x_at",0.979588787486838,0.902330139413687,-0.124131854244759,-5.93218124833452,-0.0270855766935902,"TUBB4B","tubulin beta 4B class IVb",TRUE
+"209191_at",0.504875670074508,0.032820472641135,2.27657325576949,-3.68856411833134,3.16763006155607,"TUBB6","tubulin beta 6 class V",TRUE
+"211915_s_at",0.954014881715784,0.788832811481148,-0.271088115269584,-5.90395306405613,-0.14136981603488,"TUBB7P","tubulin beta 7 pseudogene",TRUE
+"222361_at",0.797508506396963,0.331080897635085,-0.993735685905258,-5.46981955739503,-1.30747730223974,"TUBBP5","tubulin beta pseudogene 5",TRUE
+"231853_at",0.782206338814045,0.304202208369247,-1.05185721785657,-5.4147008141597,-0.764551271121437,"TUBD1","tubulin delta 1",TRUE
+"210389_x_at",0.876862063516282,0.525890406978442,-0.644465152774914,-5.73938873883457,-0.492401593893304,"TUBD1","tubulin delta 1",TRUE
+"221326_s_at",0.921797789017863,0.666729133324196,-0.436456452262361,-5.84732427570911,-0.273316141255,"TUBD1","tubulin delta 1",TRUE
+"230891_at",0.566031560451315,0.0569370966096272,-2.00845280380853,-4.14542608534254,-2.05835899241559,"TUBE1","tubulin epsilon 1",TRUE
+"226181_at",0.753862100951903,0.24711342498044,1.18877543066782,-5.2738586392649,0.563286256212676,"TUBE1","tubulin epsilon 1",TRUE
+"201714_at",0.862634144901168,0.485837221084432,-0.708804826130509,-5.69789944104013,-0.229378425330356,"TUBG1","tubulin gamma 1",TRUE
+"203894_at",0.93919895813272,0.727902640573579,-0.352353548102617,-5.87939337417751,-0.17525824561865,"TUBG2","tubulin gamma 2",TRUE
+"213563_s_at",0.909052380289506,0.622037423204306,0.499952740808013,-5.81866857085347,0.238904327848601,"TUBGCP2","tubulin gamma complex associated protein 2",TRUE
+"202476_s_at",0.95168059103032,0.778419147939511,0.284830721607613,-5.90024582890938,0.114380720606427,"TUBGCP2","tubulin gamma complex associated protein 2",TRUE
+"202477_s_at",0.986342822130003,0.93371382367437,0.0841233410517118,-5.93623725102651,0.0375051015430685,"TUBGCP2","tubulin gamma complex associated protein 2",TRUE
+"203690_at",0.508488499910913,0.0336229102028087,2.26510500778397,-3.70882295494103,1.04741853430024,"TUBGCP3","tubulin gamma complex associated protein 3",TRUE
+"215739_s_at",0.607125171829172,0.080840621964492,1.82933321080797,-4.42924920578811,0.734409166021702,"TUBGCP3","tubulin gamma complex associated protein 3",TRUE
+"1554086_at",0.762857166457304,0.262650212060594,1.14939333675402,-5.31592554842153,0.694909694909824,"TUBGCP3","tubulin gamma complex associated protein 3",TRUE
+"211337_s_at",0.842397669245069,0.436194889953815,0.79298736399049,-5.63795922868261,0.305824611106095,"TUBGCP4","tubulin gamma complex associated protein 4",TRUE
+"227907_at",0.95580680599569,0.798367462698074,-0.258552181442784,-5.90717603457543,-0.122997473831004,"TUBGCP4","tubulin gamma complex associated protein 4",TRUE
+"214876_s_at",0.817857130700434,0.370497598381911,0.914114639644641,-5.54068545362162,0.360565174770406,"TUBGCP5","tubulin gamma complex associated protein 5",TRUE
+"227967_at",0.906777991824897,0.614817868037325,0.510401321919328,-5.81358928976643,0.203810210160857,"TUBGCP5","tubulin gamma complex associated protein 5",TRUE
+"225758_s_at",0.919375181609246,0.657190923862169,0.449847063752448,-5.84159798443223,0.233017777985276,"TUBGCP6","tubulin gamma complex associated protein 6",TRUE
+"234308_at",0.998038817582822,0.991101092549373,-0.0112798889953969,-5.93962150902542,-0.00364125427633688,"TUBGCP6","tubulin gamma complex associated protein 6",TRUE
+"201113_at",0.757950630724418,0.254510525296541,-1.16980274492489,-5.29427961473312,-0.395454645526399,"TUFM","Tu translation elongation factor, mitochondrial",TRUE
+"238190_at",0.827030657485171,0.395462085217966,-0.866575881406576,-5.58039453207881,-0.438120806258588,"TUFM","Tu translation elongation factor, mitochondrial",TRUE
+"205807_s_at",0.896118799730606,0.578482177164915,0.56390547214204,-5.78597820847887,0.292307279094619,"TUFT1","tuftelin 1",TRUE
+"212725_s_at",0.662575055303091,0.130252890331745,-1.57143835379865,-4.80356828166314,-0.518086545548298,"TUG1","taurine up-regulated 1 (non-protein coding)",TRUE
+"222244_s_at",0.703948341108555,0.175708356025043,-1.39882452726392,-5.02909076572994,-0.463512601758117,"TUG1","taurine up-regulated 1 (non-protein coding)",TRUE
+"212337_at",0.744550562232364,0.235491776363681,-1.21946215902678,-5.24022482413322,-0.439043426215624,"TUG1","taurine up-regulated 1 (non-protein coding)",TRUE
+"228397_at",0.778686132916778,0.299497918500275,-1.06239822082758,-5.40440244229243,-0.460929539456489,"TUG1","taurine up-regulated 1 (non-protein coding)",TRUE
+"230635_at",0.960664106415106,0.821340105318107,0.228517195670028,-5.91428094954262,0.122654134350467,"TUG1","taurine up-regulated 1 (non-protein coding)",TRUE
+"229301_at",0.977369242833284,0.891648087729009,0.137793643230076,-5.93043979940906,0.0675832055176695,"TUG1","taurine up-regulated 1 (non-protein coding)",TRUE
+"206705_at",0.959649219607517,0.817802805547961,-0.233127268254261,-5.91324703050316,-0.160898996893422,"TULP1","tubby like protein 1",TRUE
+"206733_at",0.773234064853267,0.284232742840869,1.0974408452759,-5.36950694052366,0.63414160570229,"TULP2","tubby like protein 2",TRUE
+"205854_at",0.915421702513799,0.643528400745463,0.469175110606403,-5.83303358214609,0.159131953949831,"TULP3","tubby like protein 3",TRUE
+"221964_at",0.955904644595647,0.80038897032135,0.255899850657624,-5.90783851755154,0.0940742861805912,"TULP3","tubby like protein 3",TRUE
+"224170_s_at",0.957571530817866,0.808506653304735,0.245267654696929,-5.9104260028348,0.211401284674784,"TULP4","tubby like protein 4",TRUE
+"218184_at",0.965137507114453,0.837818129451863,0.20710667727877,-5.91881336420338,0.0794687323395618,"TULP4","tubby like protein 4",TRUE
+"232111_at",0.764430688544079,0.264533999897562,-1.14473674171807,-5.32081735930629,-0.79092202777236,"TUNAR","TCL1 upstream neural differentiation-associated RNA",TRUE
+"227388_at",0.773234064853267,0.284615190766749,-1.09654655182317,-5.37041002928233,-0.785132765630756,"TUSC1","tumor suppressor candidate 1",TRUE
+"203272_s_at",0.927465756048858,0.682244997577119,-0.414844586181098,-5.85620769698412,-0.260087057212152,"TUSC2","tumor suppressor candidate 2",TRUE
+"203273_s_at",0.953564723226096,0.785970299926245,-0.274860262358167,-5.90295359799703,-0.120806912844023,"TUSC2","tumor suppressor candidate 2",TRUE
+"209228_x_at",0.712948021516228,0.187126953071452,1.36122465362437,-5.07536530869017,1.57508015012766,"TUSC3","tumor suppressor candidate 3",TRUE
+"213423_x_at",0.744688669253745,0.236058324487966,1.21794003942077,-5.24191063991881,2.14122041029177,"TUSC3","tumor suppressor candidate 3",TRUE
+"209227_at",0.768852835478002,0.273914932564637,1.12190389292414,-5.34454996929652,1.0986943502198,"TUSC3","tumor suppressor candidate 3",TRUE
+"235801_at",0.840951887142661,0.430605272281481,0.802822741887115,-5.63054259224738,0.88277283928715,"TUSC3","tumor suppressor candidate 3",TRUE
+"232770_at",0.937409179150458,0.72225410852332,0.360002539282037,-5.87675559881311,0.293847190421392,"TUSC3","tumor suppressor candidate 3",TRUE
+"239523_at",0.827302615080557,0.396046065790919,0.865487571168509,-5.58128055825959,0.52378495439608,"TUSC5","tumor suppressor candidate 5",TRUE
+"1558601_at",0.808266620412549,0.351201819343099,0.952334322515752,-5.50734438071243,0.363129851517733,"TUSC7","tumor suppressor candidate 7 (non-protein coding)",TRUE
+"1558602_a_at",0.9071329255217,0.61578854194308,0.508993175046426,-5.81427979525264,0.190391509435225,"TUSC7","tumor suppressor candidate 7 (non-protein coding)",TRUE
+"1569436_at",0.93523910610914,0.711943404971005,0.374021854142103,-5.87177582091622,0.345636222488831,"TUSC8","tumor suppressor candidate 8 (non-protein coding)",TRUE
+"218965_s_at",0.837337084923913,0.419996009750062,-0.821711108828569,-5.61605869251736,-0.256846061321941,"TUT1","terminal uridylyl transferase 1, U6 snRNA-specific",TRUE
+"1563638_at",0.658590024406624,0.126814962962584,1.58641466071953,-4.78302039139217,0.857739304740832,"TVP23A","trans-golgi network vesicle protein 23 homolog A",TRUE
+"218446_s_at",0.579752808738885,0.0624765166728763,1.96173987679104,-4.22119998909484,0.74377813175821,"TVP23B","trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)",TRUE
+"1552377_s_at",0.811263413918865,0.35538630642896,0.943928386824551,-5.51478487447816,0.323741100171427,"TVP23C","trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)",TRUE
+"228482_at",0.411110107932987,0.0162496308761362,2.60113811651118,-3.09199096469018,0.994947139686823,"TVP23C-CDRT4///CDRT4///TVP23C","TVP23C-CDRT4 readthrough///CMT1A duplicated region transcript 4///trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)",TRUE
+"244698_at",0.62110896023334,0.0916974408813645,1.76295441145522,-4.52963196678319,0.722905730942601,"TVP23C-CDRT4///CDRT4///TVP23C","TVP23C-CDRT4 readthrough///CMT1A duplicated region transcript 4///trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)",TRUE
+"214007_s_at",0.812125226040016,0.356314280801915,-0.942073304243753,-5.516418748328,-0.277870897282163,"TWF1","twinfilin actin binding protein 1",TRUE
+"201745_at",0.839519981963042,0.426606086250068,-0.809908293901895,-5.62514631793142,-0.248464717995095,"TWF1","twinfilin actin binding protein 1",TRUE
+"244199_at",0.895213601869362,0.57287386373735,-0.57230993239596,-5.78139842108412,-0.266042761646345,"TWF1","twinfilin actin binding protein 1",TRUE
+"243033_at",0.921006039723366,0.663784178351926,0.440582088899544,-5.84557810847002,0.362586722012144,"TWF1","twinfilin actin binding protein 1",TRUE
+"214008_at",0.997470525710394,0.987271805245169,0.0161341100216917,-5.93955669438147,0.00617157962107928,"TWF1","twinfilin actin binding protein 1",TRUE
+"202009_at",0.900250794823241,0.595055731403363,0.539303800252796,-5.7990061667792,0.267100646107462,"TWF2","twinfilin actin binding protein 2",TRUE
+"213943_at",0.729273475042162,0.211547219523654,1.28650562282995,-5.16417821187952,1.99143892471597,"TWIST1","twist family bHLH transcription factor 1",TRUE
+"1554163_at",0.700061364939874,0.171679635552046,1.41255485938303,-5.01193296788272,0.619178049205628,"TWIST2","twist family bHLH transcription factor 2",TRUE
+"229404_at",0.822341260528993,0.387113294256886,0.882249875594625,-5.56751917647999,0.67126860307504,"TWIST2","twist family bHLH transcription factor 2",TRUE
+"226784_at",0.593339168375633,0.0703950333418174,1.9009499790532,-4.31797897923795,0.653646927902928,"TWISTNB","TWIST neighbor",TRUE
+"214729_at",0.849345634334037,0.450390086442556,0.76835263289354,-5.65615759423549,0.32411948639015,"TWISTNB","TWIST neighbor",TRUE
+"219201_s_at",0.62110896023334,0.0914157231671886,1.76458903932335,-4.52719249963319,1.28329138148155,"TWSG1","twisted gastrulation BMP signaling modulator 1",TRUE
+"225406_at",0.657015752622694,0.125584837375916,1.59185537220653,-4.77551789646399,0.827515095956777,"TWSG1","twisted gastrulation BMP signaling modulator 1",TRUE
+"206828_at",0.748184017928985,0.240497430658333,1.20610818022323,-5.25495273968643,0.967649423299022,"TXK","TXK tyrosine kinase",TRUE
+"1561358_at",0.831661773968529,0.406362035511097,-0.846430477106347,-5.59662743308127,-0.60094421562714,"TXLNA","taxilin alpha",TRUE
+"212300_at",0.863865128741987,0.489930806604469,-0.702094314537387,-5.70240270873249,-0.203462566180225,"TXLNA","taxilin alpha",TRUE
+"227834_at",0.597654932724127,0.0743812662740321,-1.87258997393759,-4.36240264660965,-2.06791953477505,"TXLNB","taxilin beta",TRUE
+"227520_at",0.579036829255831,0.0619265567239194,-1.96620983870112,-4.21400138120409,-0.652419169766675,"TXLNG","taxilin gamma",TRUE
+"1557954_at",0.712975827977365,0.187499720107823,-1.36002815325946,-5.07682062636366,-0.480930201080284,"TXLNG","taxilin gamma",TRUE
+"219969_at",0.714820080026392,0.190618688007038,-1.35008974260149,-5.08886750086688,-0.490646194307968,"TXLNG","taxilin gamma",TRUE
+"214131_at",0.572728296251991,0.0600863921636246,1.98142605424976,-4.18941332800914,1.57332072583597,"TXLNGY","taxilin gamma pseudogene, Y-linked",TRUE
+"223646_s_at",0.663561605222859,0.131498673847091,1.56609237876085,-4.81086609015252,0.702779093266695,"TXLNGY","taxilin gamma pseudogene, Y-linked",TRUE
+"236694_at",0.732074070325545,0.215776840828851,1.27425412183327,-5.1783350096298,0.926739286101256,"TXLNGY","taxilin gamma pseudogene, Y-linked",TRUE
+"223645_s_at",0.920119557710459,0.659846317088614,0.446110885671507,-5.84321277908882,0.164275000982226,"TXLNGY","taxilin gamma pseudogene, Y-linked",TRUE
+"232618_at",0.996168756168935,0.980955204977329,0.0241423145135401,-5.93939959933338,0.0206328966082969,"TXLNGY","taxilin gamma pseudogene, Y-linked",TRUE
+"216609_at",0.565795244949651,0.0566997845741898,2.01054275725606,-4.14200797853117,0.773149929967262,"TXN","thioredoxin",TRUE
+"208864_s_at",0.701308253942732,0.173054069425048,1.40784198849227,-5.01783786455325,0.38744468968161,"TXN","thioredoxin",TRUE
+"209077_at",0.799805845161581,0.335206206969296,-0.985109499813847,-5.47775803419673,-0.351581159936437,"TXN2","thioredoxin 2",TRUE
+"209078_s_at",0.82706053436911,0.395725810908993,-0.866084271974091,-5.58079489436085,-0.235637677470377,"TXN2","thioredoxin 2",TRUE
+"223325_at",0.56861088242915,0.0583078088304753,-1.9965305550991,-4.1648793787982,-0.691277772731315,"TXNDC11","thioredoxin domain containing 11",TRUE
+"223017_at",0.9832781796011,0.918535583413373,-0.103451156585284,-5.9344722060487,-0.03279437596162,"TXNDC12","thioredoxin domain containing 12",TRUE
+"227873_at",0.562870988664324,0.0554036476354929,-2.02209672206418,-4.12306883868412,-0.678702350982601,"TXNDC15","thioredoxin domain containing 15",TRUE
+"220495_s_at",0.664715252213907,0.13246890513256,-1.56195785299827,-4.81649674234554,-0.720412947599632,"TXNDC15","thioredoxin domain containing 15",TRUE
+"226747_at",0.731054546207485,0.214143139743088,-1.27896415792926,-5.17290615239592,-0.65041333124709,"TXNDC16","thioredoxin domain containing 16",TRUE
+"224511_s_at",0.851319596585235,0.455325739392015,0.759897906165842,-5.66227835830767,0.245552015327542,"TXNDC17","thioredoxin domain containing 17",TRUE
+"228743_at",0.959290940418208,0.815506957670568,0.236122148572933,-5.91256435007462,0.0755566219011747,"TXNDC17","thioredoxin domain containing 17",TRUE
+"1552657_a_at",0.656723416459198,0.124874579037561,-1.59501700274344,-4.77114895518421,-1.01555881847237,"TXNDC2","thioredoxin domain containing 2",TRUE
+"224168_at",0.87106619978761,0.511455517630528,-0.667325026367395,-5.72508014833762,-0.260620013115417,"TXNDC2","thioredoxin domain containing 2",TRUE
+"1564386_at",0.952827852442033,0.784149410441668,0.277261903653435,-5.90231011680524,0.153611487493349,"TXNDC8","thioredoxin domain containing 8",TRUE
+"1554047_at",0.84571977676742,0.44359491098557,-0.780085071264629,-5.64755803632986,-0.464373966167023,"TXNDC9","thioredoxin domain containing 9",TRUE
+"211758_x_at",0.910888708415045,0.628228617355421,-0.491037220479562,-5.82292149965757,-0.123164080461263,"TXNDC9","thioredoxin domain containing 9",TRUE
+"203008_x_at",0.96287357728432,0.831400962548481,-0.215432413901461,-5.91710358111398,-0.0552831709493056,"TXNDC9","thioredoxin domain containing 9",TRUE
+"201008_s_at",0.849935057946582,0.452453531676545,0.764811200492098,-5.65872918887834,0.565465101064838,"TXNIP","thioredoxin interacting protein",TRUE
+"201010_s_at",0.856257656023992,0.469913986012085,0.735224898316051,-5.67977358426767,0.483794497592477,"TXNIP","thioredoxin interacting protein",TRUE
+"201009_s_at",0.859465912277024,0.476770900924818,0.723784608566521,-5.68769976133327,0.474236361712061,"TXNIP","thioredoxin interacting protein",TRUE
+"201588_at",0.617775129514679,0.0888320546737093,-1.77978583337562,-4.50443397864671,-0.596281720148387,"TXNL1","thioredoxin like 1",TRUE
+"235561_at",0.986342822130003,0.934068397274607,-0.0836722521871477,-5.93627410468378,-0.0503202795562752,"TXNL1","thioredoxin like 1",TRUE
+"243664_at",0.994943851647199,0.976238823906856,-0.03012278214917,-5.93924153809353,-0.0166448302252142,"TXNL1","thioredoxin like 1",TRUE
+"202836_s_at",0.730101539866086,0.212822365100878,-1.28279229959987,-5.16848120256902,-0.521001980056415,"TXNL4A","thioredoxin like 4A",TRUE
+"1555461_at",0.821962235882611,0.385238326916912,-0.885800099353868,-5.56457311493969,-0.483793627232565,"TXNL4A","thioredoxin like 4A",TRUE
+"202835_at",0.851650449893991,0.455739870381596,-0.759191021356124,-5.66278720422913,-0.4287693642987,"TXNL4A","thioredoxin like 4A",TRUE
+"218794_s_at",0.875604460253057,0.523091405202691,-0.648870521056119,-5.73666853282003,-0.213858858688994,"TXNL4B","thioredoxin like 4B",TRUE
+"222748_s_at",0.951934441578502,0.780081752570277,0.2826329396194,-5.90085092676671,0.103615153079744,"TXNL4B","thioredoxin like 4B",TRUE
+"201266_at",0.879477812623217,0.533976140243993,0.631810270066859,-5.74710373311725,0.282578308710269,"TXNRD1","thioredoxin reductase 1",TRUE
+"1561080_at",0.9116561917482,0.630284210213992,0.488086036118096,-5.82431282062215,0.451393194441148,"TXNRD1","thioredoxin reductase 1",TRUE
+"210803_at",0.734935310038702,0.220016847822834,1.26215667594636,-5.19220026737517,0.622443817059256,"TXNRD2","thioredoxin reductase 2",TRUE
+"211177_s_at",0.847507224225217,0.446206546987601,-0.775563016808684,-5.65088714229989,-0.350131029822094,"TXNRD2","thioredoxin reductase 2",TRUE
+"221906_at",0.955515814503015,0.796128918192327,-0.261491490630357,-5.90643394378153,-0.131150335149903,"TXNRD3NB///TXNRD3","thioredoxin reductase 3 neighbor///thioredoxin reductase 3",TRUE
+"59631_at",0.987114612660816,0.940209742725876,-0.0758619651258813,-5.93688080274525,-0.0379493528756267,"TXNRD3NB///TXNRD3","thioredoxin reductase 3 neighbor///thioredoxin reductase 3",TRUE
+"205546_s_at",0.707694888507328,0.179169799767628,1.38722656594512,-5.04347600987077,0.490747920763987,"TYK2","tyrosine kinase 2",TRUE
+"217497_at",0.562643595171948,0.0553082786594266,2.02295632571903,-4.12165690335425,1.15781364080189,"TYMP","thymidine phosphorylase",TRUE
+"204858_s_at",0.609827382478528,0.081924174466113,1.82237324638711,-4.43990041874608,0.993767872241174,"TYMP","thymidine phosphorylase",TRUE
+"202589_at",0.683019114815084,0.151717925489431,1.48467807300248,-4.91956174859173,0.614889670248278,"TYMS","thymidylate synthetase",TRUE
+"1554696_s_at",0.702778368494677,0.174322455117052,1.40351920943158,-5.02323970755629,0.763578769178899,"TYMS","thymidylate synthetase",TRUE
+"217684_at",0.934081042629428,0.708205779918622,0.379122613052237,-5.86991742294677,0.26502886815724,"TYMS","thymidylate synthetase",TRUE
+"228989_at",0.94630837494651,0.75683166748913,-0.313501890480063,-5.8919262922927,-0.105819482019557,"TYMSOS","TYMS opposite strand",TRUE
+"206630_at",0.91994485246627,0.659264365968604,-0.446929146036818,-5.84286025263936,-0.220889949358352,"TYR","tyrosinase",TRUE
+"1555505_a_at",0.963458159500472,0.833323024467806,-0.212937092544788,-5.9176230635911,-0.17588371938337,"TYR","tyrosinase",TRUE
+"1555504_at",0.97070558355376,0.86031752844547,0.178029418405711,-5.92425805112452,0.176072483023845,"TYR","tyrosinase",TRUE
+"211432_s_at",0.764133949315833,0.264159044828872,1.14566165184434,-5.3198471205393,0.392167189879961,"TYRO3","TYRO3 protein tyrosine kinase",TRUE
+"211431_s_at",0.809411730389276,0.352623268044879,0.949471313298677,-5.50988535486025,0.379037079801275,"TYRO3","TYRO3 protein tyrosine kinase",TRUE
+"1566934_at",0.988224361618126,0.943929547220502,-0.0711336670019573,-5.93721924248857,-0.0394212024711056,"TYRO3P","TYRO3P protein tyrosine kinase pseudogene",TRUE
+"1566935_at",0.997288583476358,0.98620452988744,-0.0174871142739754,-5.93953453834781,-0.0164212703695887,"TYRO3P","TYRO3P protein tyrosine kinase pseudogene",TRUE
+"204122_at",0.921716759218618,0.665886366364717,-0.437636309396697,-5.84682655010056,-0.207009537374955,"TYROBP","TYRO protein tyrosine kinase binding protein",TRUE
+"205694_at",0.663309898243682,0.131267340125324,-1.56708190842365,-4.80951675275427,-1.70287860556052,"TYRP1","tyrosinase related protein 1",TRUE
+"238802_at",0.468732760220321,0.0247146036246729,-2.40955834654916,-3.44936454678141,-1.14848535828315,"TYSND1","trypsin domain containing 1",TRUE
+"225877_at",0.90360437116293,0.604782200491207,-0.52502209557077,-5.80630992137177,-0.203095588451028,"TYSND1","trypsin domain containing 1",TRUE
+"231422_x_at",0.925091998149497,0.675717830343596,-0.423911134098898,-5.85253492150133,-0.29014013068785,"TYSND1","trypsin domain containing 1",TRUE
+"225873_at",0.956938436670832,0.804657113459797,-0.250305939422457,-5.90921347300014,-0.11233460145672,"TYSND1","trypsin domain containing 1",TRUE
+"218347_at",0.673366993714442,0.139495431763844,-1.53273958581452,-4.85595282234801,-0.487063185452088,"TYW1","tRNA-yW synthesizing protein 1 homolog",TRUE
+"227141_at",0.788384937488466,0.314463283334851,1.02925949934458,-5.43646705915326,0.374464021110308,"TYW3","tRNA-yW synthesizing protein 3 homolog",TRUE
+"235181_at",0.888232641270866,0.55383344995625,-0.601161702059264,-5.7651776315546,-0.169511397539363,"TYW5","tRNA-yW synthesizing protein 5",TRUE
+"235686_at",0.925820623036756,0.678888549720629,-0.419502387798654,-5.85433061502919,-0.125870246163037,"TYW5","tRNA-yW synthesizing protein 5",TRUE
+"241825_at",0.966415325553387,0.843481286427209,-0.199771643586888,-5.92026409239535,-0.0604271489557684,"TYW5","tRNA-yW synthesizing protein 5",TRUE
+"232141_at",0.699120404996448,0.170461346483908,1.41675761305314,-5.00665352249676,0.556068128121389,"U2AF1","U2 small nuclear RNA auxiliary factor 1",TRUE
+"231904_at",0.7717895132349,0.281729517396322,1.10331584975705,-5.36355788229489,0.489752199293795,"U2AF1","U2 small nuclear RNA auxiliary factor 1",TRUE
+"242499_at",0.953902670233338,0.787221253335818,0.273211288951363,-5.90339219605666,0.161326174642072,"U2AF1","U2 small nuclear RNA auxiliary factor 1",TRUE
+"202858_at",0.983364220761052,0.918917109500024,-0.10296486181993,-5.93452107188372,-0.0276095651875377,"U2AF1","U2 small nuclear RNA auxiliary factor 1",TRUE
+"226700_at",0.289816987027404,0.0050076104603339,-3.11575351802502,-2.07224581228526,-1.37210635586153,"U2AF1L4","U2 small nuclear RNA auxiliary factor 1 like 4",TRUE
+"218381_s_at",0.762729892034689,0.262302813729902,-1.15025477026566,-5.31501868736423,-0.315088117437172,"U2AF2","U2 small nuclear RNA auxiliary factor 2",TRUE
+"229508_at",0.906053610890338,0.612590916471041,-0.513635898857159,-5.81199612396714,-0.362846790524571,"U2AF2","U2 small nuclear RNA auxiliary factor 2",TRUE
+"214171_s_at",0.940044918888428,0.731671571375967,0.347261749280278,-5.88111826200151,0.216043216897118,"U2AF2","U2 small nuclear RNA auxiliary factor 2",TRUE
+"218382_s_at",0.994986692564685,0.976424526557991,0.0298872875601349,-5.93924842099376,0.0114606461387226,"U2AF2","U2 small nuclear RNA auxiliary factor 2",TRUE
+"236431_at",0.645740804644555,0.116731454539279,1.63238175702896,-4.71900759463117,1.05577884558112,"U2SURP","U2 snRNP associated SURP domain containing",TRUE
+"212058_at",0.771127324207538,0.279961177604383,1.1074889439269,-5.35931504837051,0.335278181785643,"U2SURP","U2 snRNP associated SURP domain containing",TRUE
+"236696_at",0.812302873476553,0.359759297096364,0.935214797932404,-5.52243379304589,0.611263114456716,"U2SURP","U2 snRNP associated SURP domain containing",TRUE
+"212060_at",0.937113154905832,0.71936389952954,0.363924783239379,-5.8753813043337,0.112089123130371,"U2SURP","U2 snRNP associated SURP domain containing",TRUE
+"212061_at",0.966593471043185,0.844396931729034,-0.198586744662215,-5.92049355439443,-0.0710303490511421,"U2SURP","U2 snRNP associated SURP domain containing",TRUE
+"223279_s_at",0.727891850116715,0.208130316384752,1.29654192832418,-5.15249525841143,0.788013673408555,"UACA","uveal autoantigen with coiled-coil domains and ankyrin repeats",TRUE
+"238868_at",0.82706053436911,0.395615212849518,0.866290411366129,-5.58062704202156,0.781905293900423,"UACA","uveal autoantigen with coiled-coil domains and ankyrin repeats",TRUE
+"236715_x_at",0.843816788557882,0.439777162539622,0.7867248724873,-5.64263680298669,0.234556194499154,"UACA","uveal autoantigen with coiled-coil domains and ankyrin repeats",TRUE
+"1558356_at",0.954577684533304,0.79272646071653,-0.265963591149251,-5.90528888330485,-0.214922319017067,"UACA","uveal autoantigen with coiled-coil domains and ankyrin repeats",TRUE
+"209340_at",0.946318134613249,0.75701720764547,-0.313254356528807,-5.89200150085191,-0.149514016913908,"UAP1","UDP-N-acetylglucosamine pyrophosphorylase 1",TRUE
+"214755_at",0.597654932724127,0.0746841463823091,-1.87048986337279,-4.36567361605313,-0.854262231668336,"UAP1L1","UDP-N-acetylglucosamine pyrophosphorylase 1 like 1",TRUE
+"200964_at",0.639705117673934,0.110250412873187,-1.66371661500213,-4.67456611468009,-0.553922992087122,"UBA1","ubiquitin like modifier activating enzyme 1",TRUE
+"1555387_at",0.769258076576208,0.275807074549559,-1.11736809822643,-5.34921417540005,-0.29210947191329,"UBA1","ubiquitin like modifier activating enzyme 1",TRUE
+"229587_at",0.883891176412659,0.542297750576363,0.618893770235013,-5.7548263584794,0.16651790958514,"UBA2","ubiquitin like modifier activating enzyme 2",TRUE
+"201177_s_at",0.937232018318296,0.721430093022959,0.361120204960697,-5.8763654839434,0.11525021948562,"UBA2","ubiquitin like modifier activating enzyme 2",TRUE
+"209115_at",0.937623890519979,0.724016255511118,0.357613990103558,-5.87758530484764,0.131676483069411,"UBA3","ubiquitin like modifier activating enzyme 3",TRUE
+"222579_at",0.931370027472813,0.695877864153608,-0.396020319997731,-5.86358370077609,-0.244964019945513,"UBA5","ubiquitin like modifier activating enzyme 5",TRUE
+"222578_s_at",0.990810941805126,0.954674567607862,0.0574844496256692,-5.93807412732745,0.0367857287204902,"UBA5","ubiquitin like modifier activating enzyme 5",TRUE
+"218289_s_at",0.990980060324272,0.957585922357457,-0.0537882421498808,-5.93827442012335,-0.0338203063046691,"UBA5","ubiquitin like modifier activating enzyme 5",TRUE
+"221700_s_at",0.967701855457407,0.848090794109848,0.19380960304486,-5.9214048789925,0.0521240641386456,"UBA52","ubiquitin A-52 residue ribosomal protein fusion product 1",TRUE
+"222602_at",0.644844656970274,0.115116823175245,1.64004866074169,-4.70819362289156,0.65312498967589,"UBA6","ubiquitin like modifier activating enzyme 6",TRUE
+"218340_s_at",0.789378278298554,0.315959571188828,1.02600786813083,-5.43956397740024,0.52469155081654,"UBA6","ubiquitin like modifier activating enzyme 6",TRUE
+"222600_s_at",0.803583569469174,0.342010774644305,0.971039061909858,-5.49057143390338,0.437041560336082,"UBA6","ubiquitin like modifier activating enzyme 6",TRUE
+"222601_at",0.868608636812693,0.504708550136518,0.678132937398343,-5.71814887527386,0.24300410781775,"UBA6","ubiquitin like modifier activating enzyme 6",TRUE
+"220869_at",0.9116561917482,0.630595033235871,0.48764017505497,-5.82452230690356,0.187976211784234,"UBA6","ubiquitin like modifier activating enzyme 6",TRUE
+"242834_at",0.966111788889917,0.842172209573926,0.201466174902256,-5.9199335745411,0.0978194024466754,"UBA6","ubiquitin like modifier activating enzyme 6",TRUE
+"1555441_at",0.984055193758035,0.921708791127686,0.0994073386969063,-5.93487155693602,0.065750485428393,"UBA6","ubiquitin like modifier activating enzyme 6",TRUE
+"202151_s_at",0.859502367311367,0.477382373213041,-0.722769112015798,-5.68839762009573,-0.238218688372783,"UBAC1","UBA domain containing 1",TRUE
+"224298_s_at",0.959357995170594,0.816199494172432,0.235218519464319,-5.91277124466592,0.127434273385184,"UBAC2","UBA domain containing 2",TRUE
+"1557037_a_at",0.729083413548563,0.210740163371412,1.28886477641233,-5.16143893244712,1.15574247810407,"UBAC2-AS1","UBAC2 antisense RNA 1",TRUE
+"1557038_s_at",0.981055483128003,0.91068146200632,-0.113467909846643,-5.93341450421947,-0.0429964166357788,"UBAC2-AS1","UBAC2 antisense RNA 1",TRUE
+"1558976_x_at",0.648954261038999,0.119774014474626,1.61817309112645,-4.73894535845161,1.20558405832701,"UBALD1","UBA like domain containing 1",TRUE
+"225874_at",0.784552021081681,0.308356968205324,-1.04264336837788,-5.42362701220166,-0.437231873701769,"UBALD1","UBA like domain containing 1",TRUE
+"1558975_at",0.937113154905832,0.719701910296027,-0.363465776422681,-5.87554289301923,-0.26987579369776,"UBALD1","UBA like domain containing 1",TRUE
+"224785_at",0.783844746433788,0.306670043123402,1.04637372968358,-5.42002161697655,0.395576442917799,"UBALD2","UBA like domain containing 2",TRUE
+"224783_at",0.960344430556183,0.820126239625593,0.230098620105331,-5.91392859225283,0.0827070714750349,"UBALD2","UBA like domain containing 2",TRUE
+"46270_at",0.888830748858811,0.555968307857249,-0.597901483854196,-5.76704920449774,-0.205101633992941,"UBAP1","ubiquitin associated protein 1",TRUE
+"221490_at",0.956259177099841,0.801823538621714,-0.25401875548769,-5.90830425164363,-0.0833108944236933,"UBAP1","ubiquitin associated protein 1",TRUE
+"232663_s_at",0.854400503339099,0.465867996403058,0.742021603202798,-5.67500876469771,0.490413986752299,"UBAP1L","ubiquitin associated protein 1 like",TRUE
+"232557_at",0.907964244160782,0.618092095480206,-0.505655595171459,-5.81590899455635,-0.327978925340278,"UBAP1L","ubiquitin associated protein 1 like",TRUE
+"219192_at",0.853946163207709,0.462802760337088,-0.747194134803246,-5.67135471569738,-0.226943942586875,"UBAP2","ubiquitin associated protein 2",TRUE
+"221839_s_at",0.952237574337645,0.781247314509922,-0.281093041753465,-5.9012721234879,-0.0663960970491768,"UBAP2","ubiquitin associated protein 2",TRUE
+"201378_s_at",0.61760967235709,0.0877298085576686,-1.786385104581,-4.49450657895127,-0.594085407467832,"UBAP2L","ubiquitin associated protein 2 like",TRUE
+"201377_at",0.697172073261335,0.167039409835899,-1.42869244411986,-4.99159097321686,-0.543682697835365,"UBAP2L","ubiquitin associated protein 2 like",TRUE
+"214695_at",0.823073978212882,0.388985006651265,-0.878716978024582,-5.57043996702113,-0.283105320382694,"UBAP2L","ubiquitin associated protein 2 like",TRUE
+"209947_at",0.85322715768263,0.459720509157249,-0.752416011083991,-5.66764141838214,-0.281529462830678,"UBAP2L","ubiquitin associated protein 2 like",TRUE
+"220418_at",0.552420073963858,0.0497178692671688,2.07581422165376,-4.0340786276332,0.66326574804307,"UBASH3A","ubiquitin associated and SH3 domain containing A",TRUE
+"238462_at",0.481363249480408,0.027319070199135,2.36292888833497,-3.53411330457048,3.14962231347277,"UBASH3B","ubiquitin associated and SH3 domain containing B",TRUE
+"228353_x_at",0.508720272733199,0.0337285960431248,2.26361325523386,-3.71145370524588,2.81908534848067,"UBASH3B","ubiquitin associated and SH3 domain containing B",TRUE
+"228359_at",0.528328646587879,0.0409388191390675,2.17071248881161,-3.87321825196132,3.15195968198385,"UBASH3B","ubiquitin associated and SH3 domain containing B",TRUE
+"238587_at",0.54775309185967,0.0481345505538598,2.09175122099146,-4.00738500039051,3.01123175184757,"UBASH3B","ubiquitin associated and SH3 domain containing B",TRUE
+"240387_at",0.899808883319249,0.59285754075617,-0.542547154121323,-5.79732093440857,-0.351186083115874,"UBASH3B","ubiquitin associated and SH3 domain containing B",TRUE
+"200633_at",0.928167838756364,0.68430512319677,0.411990336001166,-5.85734776641121,0.0879247106541374,"UBB","ubiquitin B",TRUE
+"217144_at",0.946668227860895,0.758155880201164,-0.311735660487081,-5.8924616400962,-0.0848434390679405,"UBBP1","ubiquitin B pseudogene 1",TRUE
+"217125_at",0.877857073443889,0.529118566321531,0.639400207347251,-5.74249421395838,0.204240714384294,"UBBP2","ubiquitin B pseudogene 2",TRUE
+"208980_s_at",0.87825462101175,0.530599006826191,-0.637083038612553,-5.74390708949307,-0.143293418495578,"UBC","ubiquitin C",TRUE
+"211296_x_at",0.960208099683221,0.819814153148474,-0.230505303235788,-5.91383758834354,-0.0523658459337835,"UBC","ubiquitin C",TRUE
+"205890_s_at",0.863408882018863,0.488055365511959,0.705164648446965,-5.70034734564972,0.883492061789821,"UBD///GABBR1","ubiquitin D///gamma-aminobutyric acid type B receptor subunit 1",TRUE
+"201899_s_at",0.81390353381761,0.364861008026879,-0.925138543884671,-5.53119758578889,-0.267016729873079,"UBE2A","ubiquitin conjugating enzyme E2 A",TRUE
+"201898_s_at",0.955892698633978,0.800105597728133,-0.256271537835088,-5.90774608875537,-0.0729650789889522,"UBE2A","ubiquitin conjugating enzyme E2 A",TRUE
+"228588_s_at",0.743988868190873,0.234757002705371,-1.22144037367472,-5.23803114092206,-0.360615589830994,"UBE2B","ubiquitin conjugating enzyme E2 B",TRUE
+"202335_s_at",0.818593126679085,0.371929421262842,-0.911332094640057,-5.54306371329934,-0.402911232746473,"UBE2B","ubiquitin conjugating enzyme E2 B",TRUE
+"211763_s_at",0.827768017240356,0.396624076863498,-0.864411405266726,-5.5821556790843,-0.360396643399126,"UBE2B","ubiquitin conjugating enzyme E2 B",TRUE
+"202334_s_at",0.835885356387511,0.415550066245431,-0.829715407122397,-5.60982568008103,-0.336191206661587,"UBE2B","ubiquitin conjugating enzyme E2 B",TRUE
+"224118_at",0.90635492207204,0.613088805448785,0.512912250131456,-5.81235340361329,0.221387249388194,"UBE2B","ubiquitin conjugating enzyme E2 B",TRUE
+"202333_s_at",0.906476756086155,0.613717201904864,-0.511999313217626,-5.81280343798508,-0.135910213670643,"UBE2B","ubiquitin conjugating enzyme E2 B",TRUE
+"239163_at",0.912041701968169,0.631452026333406,0.486411377274424,-5.82509868482953,0.170200216434638,"UBE2B","ubiquitin conjugating enzyme E2 B",TRUE
+"202954_at",0.947969282616012,0.763718814809768,0.304326808029553,-5.89467462526784,0.0996171750796613,"UBE2C","ubiquitin conjugating enzyme E2 C",TRUE
+"214590_s_at",0.823074246722209,0.389246675728989,0.878223954263363,-5.57084670527585,0.256155020596951,"UBE2D1","ubiquitin conjugating enzyme E2 D1",TRUE
+"211764_s_at",0.845444642968895,0.442460960473927,0.782053567716758,-5.64610314175403,0.233636967842497,"UBE2D1","ubiquitin conjugating enzyme E2 D1",TRUE
+"215957_at",0.994050962712312,0.972035637885608,0.0354534501482219,-5.9390712866906,0.0304441514628997,"UBE2D1","ubiquitin conjugating enzyme E2 D1",TRUE
+"201344_at",0.843095426822889,0.437375892323892,-0.790919265174129,-5.63950779193802,-0.311271066498797,"UBE2D2","ubiquitin conjugating enzyme E2 D2",TRUE
+"201343_at",0.89604100266743,0.577022545275126,-0.566088863773785,-5.78479474231569,-0.168194594744723,"UBE2D2","ubiquitin conjugating enzyme E2 D2",TRUE
+"201345_s_at",0.997608949249317,0.987943096836302,-0.0152831175214052,-5.93956971626111,-0.00438024814168259,"UBE2D2","ubiquitin conjugating enzyme E2 D2",TRUE
+"223966_at",0.597654932724127,0.0746834861012787,1.870494433539,-4.36566650072938,1.67065900417303,"UBE2D3","ubiquitin conjugating enzyme E2 D3",TRUE
+"200667_at",0.831182446031643,0.40524678703265,0.848475663747957,-5.59499567829014,0.268331329786314,"UBE2D3","ubiquitin conjugating enzyme E2 D3",TRUE
+"200669_s_at",0.854116828440652,0.463537593740834,0.745952263005788,-5.67223420982367,0.195970193822301,"UBE2D3","ubiquitin conjugating enzyme E2 D3",TRUE
+"200668_s_at",0.899998627338565,0.594571457108246,-0.540017826477557,-5.79863600517054,-0.119306937515729,"UBE2D3","ubiquitin conjugating enzyme E2 D3",TRUE
+"240383_at",0.913627134030439,0.637646227936486,0.477552230762198,-5.82921206083446,0.238746566664322,"UBE2D3","ubiquitin conjugating enzyme E2 D3",TRUE
+"229355_at",0.93032716386748,0.691786796709041,-0.401653679322085,-5.86141170287303,-0.15457258774226,"UBE2D3","ubiquitin conjugating enzyme E2 D3",TRUE
+"221949_at",0.653206225743412,0.122481112471193,1.60578279014477,-4.75622156233809,0.526849483153305,"UBE2D4","ubiquitin conjugating enzyme E2 D4 (putative)",TRUE
+"218837_s_at",0.801587742916188,0.338873274624622,0.977502672850532,-5.48470613710791,0.293241329862582,"UBE2D4","ubiquitin conjugating enzyme E2 D4 (putative)",TRUE
+"58900_at",0.821896104057596,0.384969843141934,0.886309392200346,-5.56414959199047,0.241628021785143,"UBE2D4","ubiquitin conjugating enzyme E2 D4 (putative)",TRUE
+"65521_at",0.910658048874353,0.627808574965176,0.491640812748217,-5.82263592974087,0.125906222530267,"UBE2D4","ubiquitin conjugating enzyme E2 D4 (putative)",TRUE
+"51774_s_at",0.920147736488699,0.660122198117566,0.445723087471473,-5.84337963063632,0.10859262668084,"UBE2D4","ubiquitin conjugating enzyme E2 D4 (putative)",TRUE
+"1554763_at",0.784498961298069,0.307591159438202,-1.04433503618737,-5.42199345003473,-0.703305046085005,"UBE2DNL","ubiquitin conjugating enzyme E2 D N-terminal like (pseudogene)",TRUE
+"238958_at",0.710672261019989,0.183858434787172,1.37179731973876,-5.06245930498557,0.989077154715836,"UBE2E1","ubiquitin conjugating enzyme E2 E1",TRUE
+"212519_at",0.94214388523134,0.739650603302824,0.336512748721074,-5.88467805664047,0.116025360391729,"UBE2E1","ubiquitin conjugating enzyme E2 E1",TRUE
+"225651_at",0.889452275006221,0.557471741211348,0.595609454945237,-5.76835908905247,0.364647190048021,"UBE2E2","ubiquitin conjugating enzyme E2 E2",TRUE
+"239880_at",0.892746695408886,0.565626726632157,0.583232403855977,-5.77534845772238,0.423557636679546,"UBE2E2-AS1","UBE2E2 antisense RNA 1 (head to head)",TRUE
+"210024_s_at",0.668249925824654,0.134444429521192,1.55361624549377,-4.82782117714284,0.886250778023504,"UBE2E3","ubiquitin conjugating enzyme E2 E3",TRUE
+"225791_at",0.404674982264786,0.0150693783976425,-2.63503821778423,-3.02732053896329,-1.0825906359032,"UBE2F","ubiquitin conjugating enzyme E2 F (putative)",TRUE
+"225787_at",0.794443786143158,0.326411532969396,-1.00358965254538,-5.46067427239613,-0.269613349544716,"UBE2F","ubiquitin conjugating enzyme E2 F (putative)",TRUE
+"225783_at",0.861659105448003,0.483448616553232,-0.712735508994354,-5.69524270102286,-0.22403215242244,"UBE2F","ubiquitin conjugating enzyme E2 F (putative)",TRUE
+"231948_s_at",0.901003892899679,0.59719213671315,-0.536157206824949,-5.80063173270854,-0.183422790774593,"UBE2F","ubiquitin conjugating enzyme E2 F (putative)",TRUE
+"209142_s_at",0.433660982257499,0.0195640904868703,2.51700049030731,-3.25068945020639,0.738489711648754,"UBE2G1","ubiquitin conjugating enzyme E2 G1",TRUE
+"209141_at",0.526253358601247,0.0396453066472699,2.18622251790107,-3.84649938483217,0.655844110696982,"UBE2G1","ubiquitin conjugating enzyme E2 G1",TRUE
+"226005_at",0.657015752622694,0.125755108126031,1.59109964557743,-4.77656120712256,0.445145967938126,"UBE2G1","ubiquitin conjugating enzyme E2 G1",TRUE
+"232755_at",0.773107052530371,0.283827267023389,-1.09838993692179,-5.3685477983605,-0.886996318733178,"UBE2G2","ubiquitin conjugating enzyme E2 G2",TRUE
+"209041_s_at",0.868039927215454,0.501695579018849,0.682985637430607,-5.71500211690081,0.270094649066767,"UBE2G2","ubiquitin conjugating enzyme E2 G2",TRUE
+"209042_s_at",0.971242929121865,0.86317455367801,0.174348866450384,-5.92488880205508,0.0797285573759954,"UBE2G2","ubiquitin conjugating enzyme E2 G2",TRUE
+"1557053_s_at",0.978995847749076,0.898309781567368,0.129270700588224,-5.93154748688583,0.061383716858229,"UBE2G2","ubiquitin conjugating enzyme E2 G2",TRUE
+"222421_at",0.678772326285111,0.146360269102053,1.50534044483202,-4.89241401489649,0.660485901476802,"UBE2H","ubiquitin conjugating enzyme E2 H",TRUE
+"222419_x_at",0.710824498521146,0.18414132374315,1.37087641192064,-5.06358675853189,0.866187425570499,"UBE2H","ubiquitin conjugating enzyme E2 H",TRUE
+"222420_s_at",0.713330901550199,0.188008232450982,1.35839896263274,-5.07880051277873,0.544972976048895,"UBE2H","ubiquitin conjugating enzyme E2 H",TRUE
+"217799_x_at",0.74552004660471,0.237213317252511,1.21484550377517,-5.24533235733184,0.465137287563785,"UBE2H","ubiquitin conjugating enzyme E2 H",TRUE
+"221962_s_at",0.801086839730802,0.337227795261427,0.980908961578922,-5.48160088621099,0.337739066187554,"UBE2H","ubiquitin conjugating enzyme E2 H",TRUE
+"227950_at",0.847717593536494,0.446733681398886,0.77465223910262,-5.65155544169533,0.540050879658281,"UBE2H","ubiquitin conjugating enzyme E2 H",TRUE
+"226637_at",0.871959063104412,0.514516543564391,0.662447881360485,-5.72817300809954,0.427639881637043,"UBE2H","ubiquitin conjugating enzyme E2 H",TRUE
+"226681_at",0.94333312187812,0.745493175892574,-0.328667526024266,-5.88720630368591,-0.153804356285204,"UBE2H","ubiquitin conjugating enzyme E2 H",TRUE
+"213535_s_at",0.797960028258877,0.332034536186243,-0.99173502650584,-5.47166632204856,-0.291140918388242,"UBE2I","ubiquitin conjugating enzyme E2 I",TRUE
+"208760_at",0.889564853347573,0.557786042383445,-0.595130700354008,-5.76863208145551,-0.269893811434592,"UBE2I","ubiquitin conjugating enzyme E2 I",TRUE
+"233360_at",0.896115372949367,0.577726031661495,-0.565036206609921,-5.78536586884469,-0.35373410538921,"UBE2I","ubiquitin conjugating enzyme E2 I",TRUE
+"211008_s_at",0.990810941805126,0.953556487183819,-0.0589041611554406,-5.93799365900374,-0.0411844300073279,"UBE2I","ubiquitin conjugating enzyme E2 I",TRUE
+"1558088_a_at",0.993225426079816,0.968271056871267,-0.0402287489950828,-5.938895271779,-0.0126149024367717,"UBE2I","ubiquitin conjugating enzyme E2 I",TRUE
+"222435_s_at",0.3432707174245,0.00860766627506153,2.88243333471936,-2.5439232127078,0.985300944271181,"UBE2J1","ubiquitin conjugating enzyme E2 J1",TRUE
+"217825_s_at",0.496742810480539,0.0303252908497145,2.31395005490847,-3.62212166694187,0.775561689411365,"UBE2J1","ubiquitin conjugating enzyme E2 J1",TRUE
+"217824_at",0.536422380101288,0.0433036958441829,2.1434684775467,-3.91986404640104,0.913629595569869,"UBE2J1","ubiquitin conjugating enzyme E2 J1",TRUE
+"217826_s_at",0.565043084457947,0.0563095738195929,2.01399622272298,-4.1363546622479,0.831942004736174,"UBE2J1","ubiquitin conjugating enzyme E2 J1",TRUE
+"217823_s_at",0.593904766176258,0.0706558506751646,1.89905196413698,-4.3209666605456,0.806327647138485,"UBE2J1","ubiquitin conjugating enzyme E2 J1",TRUE
+"228924_s_at",0.796174477255647,0.328428451647308,0.999321354101219,-5.4646456572159,0.348296460766377,"UBE2J1","ubiquitin conjugating enzyme E2 J1",TRUE
+"230929_s_at",0.71454754703986,0.189500878171463,1.35363674969703,-5.08457646130043,0.916149477797839,"UBE2J2","ubiquitin conjugating enzyme E2 J2",TRUE
+"225209_s_at",0.85334340854827,0.461561241915741,-0.749294980325982,-5.66986374067495,-0.264764208127325,"UBE2J2","ubiquitin conjugating enzyme E2 J2",TRUE
+"224347_x_at",0.892643596418532,0.56505523314212,-0.584096763479911,-5.77486496146821,-0.232160394779573,"UBE2J2","ubiquitin conjugating enzyme E2 J2",TRUE
+"226704_at",0.989586772349659,0.949158139447184,-0.0644903096134859,-5.93765798818253,-0.018291684849566,"UBE2J2","ubiquitin conjugating enzyme E2 J2",TRUE
+"225179_at",0.857901663436784,0.473520921795981,-0.729194830380243,-5.68396611188659,-0.231541849169933,"UBE2K","ubiquitin conjugating enzyme E2 K",TRUE
+"202346_at",0.869784729509912,0.507474949664179,-0.673691721487796,-5.72100999270203,-0.218727084796866,"UBE2K","ubiquitin conjugating enzyme E2 K",TRUE
+"202347_s_at",0.959357995170594,0.816138332651709,0.235298315605525,-5.91275300633361,0.0632771211778778,"UBE2K","ubiquitin conjugating enzyme E2 K",TRUE
+"200683_s_at",0.831875452294783,0.407374620394303,-0.844576658720028,-5.59810332982777,-0.308251246304369,"UBE2L3","ubiquitin conjugating enzyme E2 L3",TRUE
+"200682_s_at",0.86481525165637,0.492555453827569,-0.697808759254752,-5.70525727279029,-0.224800153674256,"UBE2L3","ubiquitin conjugating enzyme E2 L3",TRUE
+"200684_s_at",0.901298810621856,0.597997542827955,-0.53497239047084,-5.80124142465813,-0.236489060181922,"UBE2L3","ubiquitin conjugating enzyme E2 L3",TRUE
+"200676_s_at",0.938400005975956,0.726232758060694,-0.354612578262844,-5.87862016457363,-0.132719136740105,"UBE2L3","ubiquitin conjugating enzyme E2 L3",TRUE
+"201649_at",0.774230543658252,0.287997830243322,1.08867433999231,-5.3783313808745,1.09453597468084,"UBE2L6","ubiquitin conjugating enzyme E2 L6",TRUE
+"203109_at",0.892780783477555,0.565908055404937,0.582807070765245,-5.77558612164285,0.316449571680822,"UBE2M","ubiquitin conjugating enzyme E2 M",TRUE
+"201524_x_at",0.878926574713754,0.532500096705864,-0.634112612047114,-5.74571106913033,-0.170996479476512,"UBE2N","ubiquitin conjugating enzyme E2 N",TRUE
+"201523_x_at",0.899521848673386,0.590319953401916,-0.546298613049854,-5.79535944443562,-0.169651370663505,"UBE2N","ubiquitin conjugating enzyme E2 N",TRUE
+"212751_at",0.923749415271371,0.672550397324325,-0.42832385631796,-5.85071913486927,-0.173271784343161,"UBE2N","ubiquitin conjugating enzyme E2 N",TRUE
+"217393_x_at",0.849935057946582,0.451936928681378,0.765696913727877,-5.65808708489501,0.282621530723794,"UBE2NL","ubiquitin conjugating enzyme E2 N like (gene/pseudogene)",TRUE
+"1554814_at",0.585036027492332,0.0655484724512353,1.93739255028646,-4.26021328100095,1.13454014598349,"UBE2O","ubiquitin conjugating enzyme E2 O",TRUE
+"218141_at",0.940652773011431,0.734199489497262,-0.343851794278036,-5.88225953622386,-0.154971675734627,"UBE2O","ubiquitin conjugating enzyme E2 O",TRUE
+"217978_s_at",0.594005743610726,0.0709622716447756,-1.89682991058395,-4.32446176557289,-0.623246978025518,"UBE2Q1","ubiquitin conjugating enzyme E2 Q1",TRUE
+"222480_at",0.682825347106105,0.151056123251049,-1.48719786863016,-4.91626720859819,-0.66228518459974,"UBE2Q1","ubiquitin conjugating enzyme E2 Q1",TRUE
+"231816_s_at",0.982970909614431,0.917426810099382,-0.104864549251397,-5.93432887408506,-0.0455736394920407,"UBE2Q1","ubiquitin conjugating enzyme E2 Q1",TRUE
+"224747_at",0.98539961718117,0.928648469826558,0.0905694887816449,-5.93568897318362,0.0380161266207875,"UBE2Q2","ubiquitin conjugating enzyme E2 Q2",TRUE
+"244498_x_at",0.853460708803218,0.462119160226409,0.748350477777382,-5.67053454700702,0.221617053307717,"UBE2Q2L","ubiquitin conjugating enzyme E2 Q2 like",TRUE
+"226618_at",0.632216562924782,0.103079857909191,-1.70025230399331,-4.62193886858938,-2.82844062119003,"UBE2QL1","ubiquitin conjugating enzyme E2 Q family like 1",TRUE
+"226612_at",0.683017520100356,0.151438126223639,-1.48574230787388,-4.91817084951832,-2.3590714397113,"UBE2QL1","ubiquitin conjugating enzyme E2 Q family like 1",TRUE
+"226954_at",0.42796179417767,0.0184529064666384,-2.5436136951815,-3.20077796753121,-0.71849517462141,"UBE2R2","ubiquitin conjugating enzyme E2 R2",TRUE
+"223014_at",0.824027323790285,0.391357041574666,-0.8742555606954,-5.57411286161225,-0.265070841842274,"UBE2R2","ubiquitin conjugating enzyme E2 R2",TRUE
+"202779_s_at",0.966773610653397,0.845464749698807,-0.197205292534092,-5.92075936300073,-0.0686846166437753,"UBE2S","ubiquitin conjugating enzyme E2 S",TRUE
+"223229_at",0.684874883853079,0.153405091828168,-1.47829445069408,-4.92788794125206,-0.506585439683459,"UBE2T","ubiquitin conjugating enzyme E2 T",TRUE
+"242392_at",0.769847953580141,0.277516779321945,1.11328910871514,-5.3533943491869,0.63412267385765,"UBE2U","ubiquitin conjugating enzyme E2 U (putative)",TRUE
+"1553776_at",0.769847953580141,0.278159902615577,1.11175949027329,-5.35495841795411,0.79101444371294,"UBE2U","ubiquitin conjugating enzyme E2 U (putative)",TRUE
+"228734_at",0.390415895588582,0.013017636764413,-2.70040975806219,-2.90148895725458,-1.03672204277294,"UBE2V2","ubiquitin conjugating enzyme E2 V2",TRUE
+"230411_at",0.700061364939874,0.171792230936597,-1.41216764286733,-5.01241873535145,-0.441633948864382,"UBE2V2","ubiquitin conjugating enzyme E2 V2",TRUE
+"209096_at",0.722160153958635,0.1983433362784,-1.32601457858359,-5.11774302926195,-0.416142378119595,"UBE2V2","ubiquitin conjugating enzyme E2 V2",TRUE
+"1555217_at",0.849935057946582,0.451519134886734,0.766413666648415,-5.657566955837,0.453434602567913,"UBE2W","ubiquitin conjugating enzyme E2 W (putative)",TRUE
+"222657_s_at",0.850693751204364,0.453591599607924,-0.762862140546734,-5.66013970009809,-0.27783410243708,"UBE2W","ubiquitin conjugating enzyme E2 W (putative)",TRUE
+"1562458_at",0.888773817669969,0.555621813776408,0.598430182355275,-5.76674636572458,0.370458790516969,"UBE2W","ubiquitin conjugating enzyme E2 W (putative)",TRUE
+"222656_at",0.942502815705589,0.741981751232177,-0.333380001775059,-5.88569471014384,-0.160971741219516,"UBE2W","ubiquitin conjugating enzyme E2 W (putative)",TRUE
+"218521_s_at",0.954387719376857,0.790109126445907,-0.269407516523436,-5.90439393861641,-0.116358548180187,"UBE2W","ubiquitin conjugating enzyme E2 W (putative)",TRUE
+"241887_at",0.979588787486838,0.902104802500757,0.124419789418257,-5.93214641673423,0.0514716836013251,"UBE2W","ubiquitin conjugating enzyme E2 W (putative)",TRUE
+"217750_s_at",0.840268837320073,0.429318880208883,-0.805097426061957,-5.6288150721508,-0.410068748232595,"UBE2Z","ubiquitin conjugating enzyme E2 Z",TRUE
+"222395_s_at",0.910327933615304,0.627297946536629,-0.492374824788682,-5.82228819418862,-0.274447007978637,"UBE2Z","ubiquitin conjugating enzyme E2 Z",TRUE
+"236107_at",0.943400587031071,0.746004688513227,0.327981690707327,-5.887424519993,0.225399119011049,"UBE2Z","ubiquitin conjugating enzyme E2 Z",TRUE
+"214980_at",0.731140263658803,0.214240478538229,1.27868275154347,-5.17323098534635,0.827675408153208,"UBE3A","ubiquitin protein ligase E3A",TRUE
+"212278_x_at",0.738061563377262,0.224934730180634,1.24834699371846,-5.20788944176155,1.2578684348333,"UBE3A","ubiquitin protein ligase E3A",TRUE
+"211285_s_at",0.867217775796765,0.499346136582236,0.68678110740338,-5.71252597792321,0.223485294385313,"UBE3A","ubiquitin protein ligase E3A",TRUE
+"234163_at",0.929088231432081,0.687700932039082,-0.40729310568085,-5.85920711577653,-0.293212218324078,"UBE3A","ubiquitin protein ligase E3A",TRUE
+"213128_s_at",0.945719871629175,0.754888328959095,0.316095753697615,-5.8911346566309,0.10848912245328,"UBE3A","ubiquitin protein ligase E3A",TRUE
+"234166_at",0.970540753946729,0.859650955114099,0.178888489305407,-5.9241089378199,0.122866194587506,"UBE3A","ubiquitin protein ligase E3A",TRUE
+"213291_s_at",0.982643521157831,0.915768047134452,-0.106979442801247,-5.93411077436907,-0.0325880168176944,"UBE3A","ubiquitin protein ligase E3A",TRUE
+"211575_s_at",0.998347572104896,0.99228128422903,0.00978387287102189,-5.93963685714355,0.00339612096427189,"UBE3A","ubiquitin protein ligase E3A",TRUE
+"227914_s_at",0.451974019443452,0.0217158888479351,2.46924615044446,-3.3395636809536,1.35485836370684,"UBE3B","ubiquitin protein ligase E3B",TRUE
+"213822_s_at",0.700466202059297,0.172221473770924,-1.41069333204545,-5.01426727190398,-0.547314018537879,"UBE3B","ubiquitin protein ligase E3B",TRUE
+"212403_at",0.797076936586489,0.330207527680234,-0.995571445776576,-5.46812203298575,-0.30510349353286,"UBE3B","ubiquitin protein ligase E3B",TRUE
+"228860_at",0.886783047600321,0.550213620501207,0.606704753194816,-5.76197301171244,0.346936702186564,"UBE3B","ubiquitin protein ligase E3B",TRUE
+"232301_at",0.90344422113846,0.604085082952688,0.526041992796895,-5.80579466517487,0.180256360087412,"UBE3B","ubiquitin protein ligase E3B",TRUE
+"212404_s_at",0.978257169730337,0.895201480989812,-0.133246187471926,-5.93103959387792,-0.0408460627214513,"UBE3B","ubiquitin protein ligase E3B",TRUE
+"243519_at",0.899998627338565,0.594198834064469,0.540567424666569,-5.7983507611475,0.349531412262205,"UBE3C","ubiquitin protein ligase E3C",TRUE
+"1555405_at",0.929553571318679,0.689705212185587,-0.404525073659481,-5.86029298668622,-0.306377257399012,"UBE3C","ubiquitin protein ligase E3C",TRUE
+"201817_at",0.937113154905832,0.719866309931241,0.36324255622026,-5.87562140265335,0.129064931746342,"UBE3C","ubiquitin protein ligase E3C",TRUE
+"1554793_at",0.942684843065067,0.743509803154913,0.331328353566207,-5.8863554225613,0.19966702132558,"UBE3C","ubiquitin protein ligase E3C",TRUE
+"1554794_a_at",0.943464796017993,0.746344018791879,0.327526805737355,-5.88756900461877,0.117066925530791,"UBE3C","ubiquitin protein ligase E3C",TRUE
+"233327_at",0.808309985919704,0.351250790223434,-0.952235557532075,-5.50743215317631,-0.617770862630419,"UBE3D","ubiquitin protein ligase E3D",TRUE
+"227790_at",0.894538680437601,0.571117394612738,0.574950684036042,-5.77994585936521,0.266301253530836,"UBE3D","ubiquitin protein ligase E3D",TRUE
+"1569262_x_at",0.986421906591669,0.936126407509556,-0.0810543978201135,-5.93648407243104,-0.0616906668254678,"UBE3D","ubiquitin protein ligase E3D",TRUE
+"202038_at",0.948989397056643,0.769990373878363,0.295994967500072,-5.89710027217473,0.100723773283447,"UBE4A","ubiquitination factor E4A",TRUE
+"202317_s_at",0.780216511409289,0.30160067035594,1.05767208777529,-5.40903118228385,0.408295686421065,"UBE4B","ubiquitination factor E4B",TRUE
+"210685_s_at",0.834454640870101,0.41280832477041,0.834678493159753,-5.60593249596716,0.29501796546419,"UBE4B","ubiquitination factor E4B",TRUE
+"226746_s_at",0.872238421308015,0.51523015940471,0.661313195992077,-5.7288894553283,0.200403181147318,"UBE4B","ubiquitination factor E4B",TRUE
+"202316_x_at",0.894886481545087,0.57221995942017,0.573292559227113,-5.78085867789376,0.369262301934036,"UBE4B","ubiquitination factor E4B",TRUE
+"215533_s_at",0.9116561917482,0.630688740283574,0.487505776352162,-5.82458541696943,0.168750160425397,"UBE4B","ubiquitination factor E4B",TRUE
+"205687_at",0.599731655615302,0.0760906215649102,-1.86083395269993,-4.38067951408738,-0.725926451821607,"UBFD1","ubiquitin family domain containing 1",TRUE
+"224878_at",0.714795139167042,0.190436435541582,-1.35066694272263,-5.08816986691372,-0.506453299618679,"UBFD1","ubiquitin family domain containing 1",TRUE
+"230474_at",0.913233126230689,0.63610134712508,0.479758115061055,-5.82819476330148,0.334947008662847,"UBIAD1","UbiA prenyltransferase domain containing 1",TRUE
+"229348_at",0.917625409342001,0.650653897930877,0.459072675998734,-5.83755407799926,0.128980745680364,"UBIAD1","UbiA prenyltransferase domain containing 1",TRUE
+"219131_at",0.923376218980614,0.671180936346183,-0.430234401524742,-5.84992723575354,-0.17362670392235,"UBIAD1","UbiA prenyltransferase domain containing 1",TRUE
+"201535_at",0.803111243433434,0.3407588359541,-0.973613311578917,-5.48823972641195,-0.613603358960299,"UBL3","ubiquitin like 3",TRUE
+"201534_s_at",0.867026157046741,0.498654059139646,-0.687901073292476,-5.71179281450329,-0.514700736539892,"UBL3","ubiquitin like 3",TRUE
+"221746_at",0.657015752622694,0.125134677731267,-1.59385747026612,-4.77275205462256,-0.564601536383828,"UBL4A","ubiquitin like 4A",TRUE
+"1558584_at",0.970540753946729,0.859756933286913,0.178751896842266,-5.92413269471315,0.0499143673592961,"UBL4B","ubiquitin like 4B",TRUE
+"218011_at",0.943512938262733,0.747307162501885,0.326236058982123,-5.88797790255016,0.119011176395288,"UBL5","ubiquitin like 5",TRUE
+"225063_at",0.917106560962976,0.649692631776867,-0.460432696103769,-5.83695112981155,-0.172757124893691,"UBL7","ubiquitin like 7",TRUE
+"238511_at",0.976371465776674,0.886718342236184,-0.144107438678484,-5.92957372221272,-0.0753956812205887,"UBL7-AS1","UBL7 antisense RNA 1 (head to head)",TRUE
+"239792_at",0.986611998306681,0.937603401793136,-0.0791759729433516,-5.93663062369541,-0.0431705978687118,"UBL7-AS1","UBL7 antisense RNA 1 (head to head)",TRUE
+"243916_x_at",0.728385463227073,0.209727336901819,1.29183533311007,-5.15798366693491,0.424201264748847,"UBLCP1","ubiquitin like domain containing CTD phosphatase 1",TRUE
+"227413_at",0.960138290470901,0.819630487123795,0.230744658917097,-5.91378395273247,0.092724574303217,"UBLCP1","ubiquitin like domain containing CTD phosphatase 1",TRUE
+"207253_s_at",0.584247456664678,0.0648396146822752,-1.94291999412909,-4.25138558400445,-0.528391704745713,"UBN1","ubinuclein 1",TRUE
+"209088_s_at",0.854763246850622,0.466621296255346,-0.740753521303462,-5.67590090712958,-0.22837982506401,"UBN1","ubinuclein 1",TRUE
+"225445_at",0.726696341943087,0.206475767495759,-1.30144767322398,-5.14675659449691,-0.427862964041637,"UBN2","ubinuclein 2",TRUE
+"238349_at",0.770008266045778,0.278610835446893,1.11068851563116,-5.35605237822987,0.717770401566739,"UBN2","ubinuclein 2",TRUE
+"238350_at",0.869060996512026,0.505601030640562,-0.676698644071295,-5.7190748412507,-0.299493674633831,"UBN2","ubinuclein 2",TRUE
+"225444_at",0.982243328340126,0.914747462705523,-0.108280917750774,-5.93397439687862,-0.042985434073243,"UBN2","ubinuclein 2",TRUE
+"240932_at",0.995126858395038,0.977726926495164,-0.0282357266377075,-5.93929517408053,-0.0187406703733348,"UBN2","ubinuclein 2",TRUE
+"215544_s_at",0.769847953580141,0.277809426776925,-1.11259275014955,-5.35410662767786,-0.420165431650464,"UBOX5","U-box domain containing 5",TRUE
+"204598_at",0.848376789225697,0.448432538163936,-0.771721408784821,-5.65370096115633,-0.268611661674603,"UBOX5","U-box domain containing 5",TRUE
+"218082_s_at",0.958512954791761,0.811900355963713,-0.240831350673114,-5.91147336331121,-0.0702011468164301,"UBP1","upstream binding protein 1 (LBP-1a)",TRUE
+"222989_s_at",0.825277018878999,0.392697885480266,-0.871741409527904,-5.57617500640601,-0.295541695836206,"UBQLN1","ubiquilin 1",TRUE
+"222990_at",0.912722788750542,0.634328656804245,-0.482292260400289,-5.82702042105622,-0.141367019029522,"UBQLN1","ubiquilin 1",TRUE
+"222991_s_at",0.971216837324271,0.86207492291153,-0.175765167012395,-5.92464763991489,-0.0643540585025804,"UBQLN1","ubiquilin 1",TRUE
+"215884_s_at",0.90496994347229,0.610571206825969,0.516574269881155,-5.81054034783389,0.147032397359743,"UBQLN2","ubiquilin 2",TRUE
+"239888_at",0.979388236370534,0.900609722480724,-0.126330474553118,-5.93191323913207,-0.0448106491386113,"UBQLN2","ubiquilin 2",TRUE
+"220422_at",0.841813886364358,0.433897666632071,-0.797020028173644,-5.6349286851061,-0.311936105013383,"UBQLN3","ubiquilin 3",TRUE
+"224513_s_at",0.93523910610914,0.711911845561027,-0.374064880982656,-5.87176024847576,-0.142116072612421,"UBQLN4","ubiquilin 4",TRUE
+"222252_x_at",0.994061569423518,0.972372053656084,-0.0350267559960935,-5.93908593350292,-0.0165761832075155,"UBQLN4","ubiquilin 4",TRUE
+"236965_at",0.7768734672127,0.295102698963904,1.07235388487868,-5.3945914724335,0.774274231583208,"UBQLNL","ubiquilin-like",TRUE
+"226921_at",0.865345395265289,0.495050191940476,-0.69374743583696,-5.70794708848388,-0.274479982420894,"UBR1","ubiquitin protein ligase E3 component n-recognin 1",TRUE
+"238528_at",0.943988850936011,0.749788232346586,-0.322913675930808,-5.88902305459497,-0.124933360692527,"UBR1","ubiquitin protein ligase E3 component n-recognin 1",TRUE
+"215558_at",0.657183268009571,0.126100333592874,1.58957001374679,-4.77867174257724,1.6781183340403,"UBR2","ubiquitin protein ligase E3 component n-recognin 2",TRUE
+"1569140_at",0.88698237223329,0.550919851556536,0.605621799864076,-5.76260133418857,0.412225390528369,"UBR2","ubiquitin protein ligase E3 component n-recognin 2",TRUE
+"212756_s_at",0.936992192746977,0.717887730052111,0.365930305267678,-5.87467291906622,0.115677557006736,"UBR2","ubiquitin protein ligase E3 component n-recognin 2",TRUE
+"212760_at",0.986611998306681,0.937557079205783,-0.0792348810242223,-5.93662607995238,-0.0286864843373902,"UBR2","ubiquitin protein ligase E3 component n-recognin 2",TRUE
+"234982_at",0.606900628956089,0.0805134449722462,-1.83145066475803,-4.42600297115853,-0.53252413090377,"UBR3","ubiquitin protein ligase E3 component n-recognin 3 (putative)",TRUE
+"230029_x_at",0.627092759817312,0.0982687519511119,-1.72599541623071,-4.58434209456211,-0.493128738810645,"UBR3","ubiquitin protein ligase E3 component n-recognin 3 (putative)",TRUE
+"244121_at",0.835952408568777,0.41682731149901,-0.827410405880521,-5.61162640141609,-0.385417857981482,"UBR3","ubiquitin protein ligase E3 component n-recognin 3 (putative)",TRUE
+"235265_at",0.924812035112346,0.674773534416535,0.425225784762093,-5.85199588966402,0.306432496947718,"UBR3","ubiquitin protein ligase E3 component n-recognin 3 (putative)",TRUE
+"215636_at",0.606900628956089,0.0805226355342211,1.8313910826076,-4.42609435240445,1.37519475712662,"UBR4","ubiquitin protein ligase E3 component n-recognin 4",TRUE
+"231889_at",0.625932126245264,0.0969401259570077,1.7332937553999,-4.57360651036309,1.01450017279673,"UBR4","ubiquitin protein ligase E3 component n-recognin 4",TRUE
+"211950_at",0.775469938861376,0.2923879796914,1.07855614794039,-5.38843798409701,0.402205488040941,"UBR4","ubiquitin protein ligase E3 component n-recognin 4",TRUE
+"232907_at",0.923351546840065,0.670793671456315,-0.43077497270907,-5.84970254682504,-0.227353883006739,"UBR4","ubiquitin protein ligase E3 component n-recognin 4",TRUE
+"1563113_at",0.957571530817866,0.809583825507252,0.243859016648521,-5.91076062567927,0.189251190432276,"UBR4","ubiquitin protein ligase E3 component n-recognin 4",TRUE
+"208884_s_at",0.611470335211357,0.0835485090152297,-1.81208764332672,-4.45558751924884,-0.565662535454948,"UBR5","ubiquitin protein ligase E3 component n-recognin 5",TRUE
+"208883_at",0.711977799428804,0.185817083372068,-1.36544402616391,-5.07022471749465,-0.456900667496226,"UBR5","ubiquitin protein ligase E3 component n-recognin 5",TRUE
+"208882_s_at",0.741260241503758,0.231803260862406,-1.22944030023336,-5.22912852329773,-0.419571548161965,"UBR5","ubiquitin protein ligase E3 component n-recognin 5",TRUE
+"1555888_at",0.872668627020452,0.516685541721968,-0.659001763954742,-5.73034526504339,-0.262015808089219,"UBR5-AS1","UBR5 antisense RNA 1",TRUE
+"218108_at",0.508488499910913,0.0336760284989011,-2.26435471001727,-3.71014625603283,-0.90805672937959,"UBR7","ubiquitin protein ligase E3 component n-recognin 7 (putative)",TRUE
+"219172_at",0.995093023501737,0.97696567733973,-0.0292010493458831,-5.93926816992727,-0.0119884076644272,"UBTD1","ubiquitin domain containing 1",TRUE
+"224827_at",0.873301865850313,0.518048698303458,-0.656840073014992,-5.73170233997884,-0.297174271386369,"UBTD2","ubiquitin domain containing 2",TRUE
+"224834_at",0.997275650300134,0.986124123381949,0.0175890483765229,-5.93953279690027,0.00652959368137473,"UBTD2","ubiquitin domain containing 2",TRUE
+"225982_at",0.683838837468118,0.152653146201668,-1.48113245010171,-4.92418989548795,-0.411806784539465,"UBTF","upstream binding transcription factor, RNA polymerase I",TRUE
+"214881_s_at",0.813442508625161,0.36377448467518,-0.927276568109527,-5.5293453436638,-0.269752471800592,"UBTF","upstream binding transcription factor, RNA polymerase I",TRUE
+"202692_s_at",0.88767000285873,0.552259141401127,-0.603570099768915,-5.76378874621683,-0.14310997686635,"UBTF","upstream binding transcription factor, RNA polymerase I",TRUE
+"239920_at",0.910276798053706,0.627133643370809,-0.492611063648663,-5.82217616908244,-0.304256939198404,"UBTF","upstream binding transcription factor, RNA polymerase I",TRUE
+"1558215_s_at",0.984397001287044,0.923953203562692,-0.0965481720161396,-5.93514431730165,-0.0231882024815331,"UBTF","upstream binding transcription factor, RNA polymerase I",TRUE
+"201871_s_at",0.841420204214686,0.43231462620416,-0.79980665917799,-5.63282608891343,-0.242926450376245,"UBXN1","UBX domain protein 1",TRUE
+"210623_at",0.855405088766616,0.468316240143513,-0.737904735697373,-5.67789985514581,-0.332513682810315,"UBXN1","UBX domain protein 1",TRUE
+"232109_at",0.820288124919738,0.378623517235946,0.898416223685035,-5.55401531309971,0.691024849603762,"UBXN10","UBX domain protein 10",TRUE
+"230092_at",0.841550580403629,0.432916096859347,0.798747146348292,-5.63362633584545,0.38843183836058,"UBXN10","UBX domain protein 10",TRUE
+"238657_at",0.841967750949524,0.434728855143421,0.795559399484971,-5.63602801645162,0.647849837612901,"UBXN10","UBX domain protein 10",TRUE
+"229716_at",0.839519981963042,0.427060394605811,0.809101298918282,-5.62576316223572,0.491438163185089,"UBXN10-AS1","UBXN10 antisense RNA 1",TRUE
+"227716_at",0.686998148149102,0.155656265372778,1.4698650757045,-4.9388380241384,0.467085675800295,"UBXN11","UBX domain protein 11",TRUE
+"228605_at",0.818715626618207,0.372363996106355,0.910488965058032,-5.54378302121073,0.337112628593099,"UBXN2A","UBX domain protein 2A",TRUE
+"235327_x_at",0.980570785147084,0.909223692583261,0.115328353769235,-5.93320731035913,0.0380907299254591,"UBXN2A","UBX domain protein 2A",TRUE
+"212934_at",0.908801761853008,0.621203235632769,-0.501157127852137,-5.81808831974644,-0.170081916986156,"UBXN2B","UBX domain protein 2B",TRUE
+"238903_at",0.936143408699214,0.715283314301504,0.369472399285635,-5.87341240293136,0.134934140522907,"UBXN2B","UBX domain protein 2B",TRUE
+"212008_at",0.838294736493351,0.423051934300716,-0.816240175575066,-5.62028638641754,-0.232390260940543,"UBXN4","UBX domain protein 4",TRUE
+"212006_at",0.855347208215553,0.46782245373358,-0.738734038333658,-5.67731870038784,-0.196761056583274,"UBXN4","UBX domain protein 4",TRUE
+"1562741_at",0.892571140407054,0.564836847612778,0.584427180931506,-5.77467995304371,0.209854209614468,"UBXN4","UBX domain protein 4",TRUE
+"212007_at",0.984441970220849,0.924110726889522,-0.096347533617061,-5.93516315930983,-0.0330972631977975,"UBXN4","UBX domain protein 4",TRUE
+"217100_s_at",0.304824368772306,0.00597046427318065,3.04054834213334,-2.2257376865644,1.07272615980232,"UBXN7","UBX domain protein 7",TRUE
+"212840_at",0.328663980090165,0.00781162243485927,2.92461403314172,-2.45968042165089,0.888220087772185,"UBXN7","UBX domain protein 7",TRUE
+"242507_at",0.915746779716325,0.644665634225539,0.467559456496105,-5.83376300518899,0.167524569794195,"UBXN7-AS1","UBXN7 antisense RNA 1",TRUE
+"215983_s_at",0.695744345349551,0.16560474515672,-1.43375463024502,-4.98517090237524,-0.467229813403836,"UBXN8","UBX domain protein 8",TRUE
+"227919_at",0.102145050835817,0.000472660226089834,4.09505092156213,0.0044586769849273,5.18108398998828,"UCA1","urothelial cancer associated 1 (non-protein coding)",TRUE
+"201387_s_at",0.11175913050536,0.000559565889772109,4.02607694018068,-0.144434467330141,5.55693044205119,"UCHL1","ubiquitin C-terminal hydrolase L1",TRUE
+"1555834_at",0.467779512429724,0.0246060151394218,2.41159957855649,-3.4456336832864,0.990854396372431,"UCHL1","ubiquitin C-terminal hydrolase L1",TRUE
+"204616_at",0.498206796273596,0.0311544405388098,2.30122682308019,-3.64480982056707,0.782893808118432,"UCHL3","ubiquitin C-terminal hydrolase L3",TRUE
+"1570145_at",0.741260241503758,0.231617048635254,1.22994722249714,-5.22856271061749,0.313897126387606,"UCHL5","ubiquitin C-terminal hydrolase L5",TRUE
+"220083_x_at",0.822173415758858,0.386673382950586,-0.883081832269597,-5.56682978280272,-0.326897735216454,"UCHL5","ubiquitin C-terminal hydrolase L5",TRUE
+"219960_s_at",0.879161148925378,0.532964615804245,-0.633387680678168,-5.74615009861191,-0.210913561105059,"UCHL5","ubiquitin C-terminal hydrolase L5",TRUE
+"229248_at",0.893914276642775,0.570016067990561,-0.576608573432009,-5.77903061762372,-0.212243775816704,"UCHL5","ubiquitin C-terminal hydrolase L5",TRUE
+"223142_s_at",0.567292616148537,0.0573271165804772,-2.00503474398797,-4.15101118609635,-0.794299735901676,"UCK1","uridine-cytidine kinase 1",TRUE
+"223141_at",0.689671882692226,0.15856747454919,-1.45910959898878,-4.95273617085093,-0.50809688154561,"UCK1","uridine-cytidine kinase 1",TRUE
+"218533_s_at",0.779854829728531,0.301194891467373,-1.05858228280628,-5.40814118277187,-0.308360795996652,"UCKL1","uridine-cytidine kinase 1 like 1",TRUE
+"232727_at",0.935094665155941,0.711469953607966,0.374667414430596,-5.87154199158409,0.154619441303184,"UCKL1","uridine-cytidine kinase 1 like 1",TRUE
+"232675_s_at",0.990918916504081,0.957282204362729,0.0541738006730303,-5.93825414863371,0.0169747772599251,"UCKL1","uridine-cytidine kinase 1 like 1",TRUE
+"236800_at",0.863048163988985,0.487079601210939,0.706764787482839,-5.69927278190697,0.521869997457805,"UCMA","upper zone of growth plate and cartilage matrix associated",TRUE
+"206072_at",0.997674669021782,0.98868396751328,0.014343933414799,-5.93958326877361,0.0113432284808797,"UCN","urocortin",TRUE
+"232674_at",0.744931128252932,0.236549630103491,1.21662230474173,-5.24336861850347,0.991119913719431,"UCN2","urocortin 2",TRUE
+"1552676_at",0.921903538483936,0.666873067161219,0.436255010702657,-5.84740912248178,0.236944573938903,"UCN3","urocortin 3",TRUE
+"221384_at",0.7768734672127,0.294601509933759,1.07349585415571,-5.39346086629501,0.460151084672113,"UCP1","uncoupling protein 1",TRUE
+"208998_at",0.560467295493135,0.0543332592564867,-2.03182118445184,-4.10707281427683,-1.12091315153155,"UCP2","uncoupling protein 2",TRUE
+"208997_s_at",0.615637099066718,0.0859569010917372,-1.79715117930813,-4.4782535752526,-1.03485748808781,"UCP2","uncoupling protein 2",TRUE
+"219827_at",0.462049949204478,0.0232723283222899,-2.43737443622916,-3.39837530415166,-1.30175328107001,"UCP3","uncoupling protein 3",TRUE
+"207349_s_at",0.839519981963042,0.427275861847272,-0.808718748066703,-5.62605537171165,-0.609538746555158,"UCP3","uncoupling protein 3",TRUE
+"1554396_at",0.754682106570676,0.248277260157768,1.18576247362857,-5.2771207435281,0.474610306936809,"UEVLD","UEV and lactate/malate dehyrogenase domains",TRUE
+"1554397_s_at",0.901430889731657,0.598181196410813,0.534702329982749,-5.80138021086023,0.167973934878761,"UEVLD","UEV and lactate/malate dehyrogenase domains",TRUE
+"220775_s_at",0.947778780715578,0.76222610302007,0.306313114638574,-5.89408650083254,0.102792592605049,"UEVLD","UEV and lactate/malate dehyrogenase domains",TRUE
+"230176_at",0.974803029853857,0.876511505325566,0.157199291326158,-5.92765452574911,0.050326529873697,"UEVLD","UEV and lactate/malate dehyrogenase domains",TRUE
+"217797_at",0.769258076576208,0.276637444931713,-1.11538471859922,-5.35124844714768,-0.370010553858124,"UFC1","ubiquitin-fold modifier conjugating enzyme 1",TRUE
+"209103_s_at",0.907224306064369,0.616284786248793,0.508273681167635,-5.81463189144574,0.210885124289703,"UFD1L","ubiquitin fusion degradation 1 like (yeast)",TRUE
+"212634_at",0.796969171415842,0.329996983478432,0.996014496644199,-5.46771191821391,0.461638740550113,"UFL1","UFM1 specific ligase 1",TRUE
+"238291_at",0.865345395265289,0.495057406745982,0.693735707442128,-5.70795483450401,0.546628626471219,"UFL1","UFM1 specific ligase 1",TRUE
+"212633_at",0.906970705662734,0.615366601200268,0.50960515197194,-5.81397993195922,0.190036872532973,"UFL1","UFM1 specific ligase 1",TRUE
+"242669_at",0.403630903577261,0.0150014982351028,2.63706301868892,-3.02344505351853,1.05697938474234,"UFM1","ubiquitin fold modifier 1",TRUE
+"218050_at",0.595997098747707,0.0725590418452151,1.88538489795369,-4.34241843932781,0.646845369004142,"UFM1","ubiquitin fold modifier 1",TRUE
+"222502_s_at",0.649220725475646,0.119932175278138,1.61744278604318,-4.7399664958623,0.599404223413183,"UFM1","ubiquitin fold modifier 1",TRUE
+"240280_at",0.515810181619652,0.0361227536469233,-2.23091401970608,-3.76885956907681,-1.62261841274557,"UFSP1","UFM1 specific peptidase 1 (inactive)",TRUE
+"218449_at",0.97589003385521,0.884682021546109,-0.14671720289841,-5.92920442563914,-0.0561693555609981,"UFSP2","UFM1 specific peptidase 2",TRUE
+"1558388_a_at",0.968767226337314,0.852716596704543,-0.187833703420444,-5.92251375856938,-0.169182414027333,"UG0898H09","uncharacterized LOC643763",TRUE
+"1558387_at",0.978255630670068,0.894852909777193,-0.133692142697887,-5.93098166238791,-0.139353664427427,"UG0898H09","uncharacterized LOC643763",TRUE
+"204881_s_at",0.94895689004559,0.769330379996434,0.29687076044319,-5.89684844240932,0.237306621668282,"UGCG","UDP-glucose ceramide glucosyltransferase",TRUE
+"224967_at",0.979347742195592,0.900516294305281,0.12644988998214,-5.931898548017,0.0847542635423615,"UGCG","UDP-glucose ceramide glucosyltransferase",TRUE
+"221765_at",0.993886871642409,0.971091551349047,-0.0366509219925116,-5.93902923485557,-0.0288389781880642,"UGCG","UDP-glucose ceramide glucosyltransferase",TRUE
+"203343_at",0.964685626382167,0.83678217224194,0.208449716090996,-5.91854209474075,0.142816105367213,"UGDH","UDP-glucose 6-dehydrogenase",TRUE
+"222569_at",0.465776708318531,0.0240686211724933,-2.42182581365142,-3.4269166143951,-0.781155186854505,"UGGT1","UDP-glucose glycoprotein glucosyltransferase 1",TRUE
+"218257_s_at",0.517859245504688,0.0369835244757659,-2.21963898711744,-3.78853711924789,-0.780116939638537,"UGGT1","UDP-glucose glycoprotein glucosyltransferase 1",TRUE
+"231968_at",0.534211007350826,0.0423286688883503,-2.1545340614917,-3.90096253498241,-0.749477496156727,"UGGT1","UDP-glucose glycoprotein glucosyltransferase 1",TRUE
+"244814_at",0.76029267756668,0.258878667450763,1.15879096294421,-5.30600008119801,0.572689988235796,"UGGT1","UDP-glucose glycoprotein glucosyltransferase 1",TRUE
+"222568_at",0.942502815705589,0.742378853067586,0.332846690583048,-5.88586684572768,0.0816486268375876,"UGGT1","UDP-glucose glycoprotein glucosyltransferase 1",TRUE
+"1558466_at",0.767011398042819,0.268700889543252,1.1345225451286,-5.33148621801499,0.644164114381033,"UGGT2","UDP-glucose glycoprotein glucosyltransferase 2",TRUE
+"1555561_a_at",0.81761995306166,0.370116028134908,0.914857371049617,-5.54004950551757,0.544877855477588,"UGGT2","UDP-glucose glycoprotein glucosyltransferase 2",TRUE
+"235749_at",0.82706053436911,0.395553622250797,0.866405223804598,-5.58053353802783,0.774167555240711,"UGGT2","UDP-glucose glycoprotein glucosyltransferase 2",TRUE
+"1558467_a_at",0.837207729029712,0.419744641393004,0.822162236463138,-5.61570890026773,0.288109555934461,"UGGT2","UDP-glucose glycoprotein glucosyltransferase 2",TRUE
+"233945_at",0.924696623416105,0.674357348857431,-0.425805440962535,-5.85175769853058,-0.36542690237075,"UGGT2","UDP-glucose glycoprotein glucosyltransferase 2",TRUE
+"218801_at",0.966111788889917,0.842213236532058,0.201413058521927,-5.91994397709414,0.0931609031584415,"UGGT2","UDP-glucose glycoprotein glucosyltransferase 2",TRUE
+"1555560_at",0.991689960875868,0.961070092105575,-0.0493658029342857,-5.93849658612931,-0.0544036715482084,"UGGT2","UDP-glucose glycoprotein glucosyltransferase 2",TRUE
+"205480_s_at",0.690381347688918,0.160024997439396,1.45378469623868,-4.95958630946008,0.400993653336958,"UGP2","UDP-glucose pyrophosphorylase 2",TRUE
+"232180_at",0.913844341298172,0.638612978368917,0.47617306224738,-5.82984576807351,0.462573107925973,"UGP2","UDP-glucose pyrophosphorylase 2",TRUE
+"232655_at",0.96736559784358,0.847246718603386,0.194900805265087,-5.92119866098512,0.156987522237465,"UGT1A1","UDP glucuronosyltransferase family 1 member A1",TRUE
+"207126_x_at",0.678611044120554,0.146040038768959,1.50659489167431,-4.89075614444486,1.86695103630683,"UGT1A1///UGT1A4///UGT1A9///UGT1A6///UGT1A8///UGT1A10","UDP glucuronosyltransferase family 1 member A1///UDP glucuronosyltransferase family 1 member A4///UDP glucuronosyltransferase family 1 member A9///UDP glucuronosyltransferase family 1 member A6///UDP glucuronosyltransferase family 1 member A8///UDP glucuronosyltransferase family 1 member A10",TRUE
+"204532_x_at",0.698391916012681,0.16959059665133,1.41977621459399,-5.0028536426804,1.6879767951831,"UGT1A1///UGT1A4///UGT1A9///UGT1A6///UGT1A8///UGT1A10","UDP glucuronosyltransferase family 1 member A1///UDP glucuronosyltransferase family 1 member A4///UDP glucuronosyltransferase family 1 member A9///UDP glucuronosyltransferase family 1 member A6///UDP glucuronosyltransferase family 1 member A8///UDP glucuronosyltransferase family 1 member A10",TRUE
+"215125_s_at",0.6287528932499,0.0998436206269386,1.71745269811415,-4.59686521993512,2.4955179324017,"UGT1A3///UGT1A1///UGT1A4///UGT1A9///UGT1A5///UGT1A6///UGT1A7///UGT1A8///UGT1A10","UDP glucuronosyltransferase family 1 member A3///UDP glucuronosyltransferase family 1 member A1///UDP glucuronosyltransferase family 1 member A4///UDP glucuronosyltransferase family 1 member A9///UDP glucuronosyltransferase family 1 member A5///UDP glucuronosyltransferase family 1 member A6///UDP glucuronosyltransferase family 1 member A7///UDP glucuronosyltransferase family 1 member A8///UDP glucuronosyltransferase family 1 member A10",TRUE
+"206094_x_at",0.657571067962164,0.126320085703295,1.58859814619168,-4.78001187080967,1.76834032191073,"UGT1A3///UGT1A1///UGT1A4///UGT1A9///UGT1A5///UGT1A6///UGT1A7///UGT1A8///UGT1A10","UDP glucuronosyltransferase family 1 member A3///UDP glucuronosyltransferase family 1 member A1///UDP glucuronosyltransferase family 1 member A4///UDP glucuronosyltransferase family 1 member A9///UDP glucuronosyltransferase family 1 member A5///UDP glucuronosyltransferase family 1 member A6///UDP glucuronosyltransferase family 1 member A7///UDP glucuronosyltransferase family 1 member A8///UDP glucuronosyltransferase family 1 member A10",TRUE
+"208596_s_at",0.692289844352812,0.161849460372707,1.44717415964863,-4.96806198956989,2.12454021710775,"UGT1A3///UGT1A1///UGT1A4///UGT1A9///UGT1A5///UGT1A6///UGT1A7///UGT1A8///UGT1A10","UDP glucuronosyltransferase family 1 member A3///UDP glucuronosyltransferase family 1 member A1///UDP glucuronosyltransferase family 1 member A4///UDP glucuronosyltransferase family 1 member A9///UDP glucuronosyltransferase family 1 member A5///UDP glucuronosyltransferase family 1 member A6///UDP glucuronosyltransferase family 1 member A7///UDP glucuronosyltransferase family 1 member A8///UDP glucuronosyltransferase family 1 member A10",TRUE
+"221304_at",0.631360647647282,0.102665144521861,1.70243059908022,-4.61877395737411,0.874379408219185,"UGT1A3///UGT1A1///UGT1A9///UGT1A5///UGT1A8","UDP glucuronosyltransferase family 1 member A3///UDP glucuronosyltransferase family 1 member A1///UDP glucuronosyltransferase family 1 member A9///UDP glucuronosyltransferase family 1 member A5///UDP glucuronosyltransferase family 1 member A8",TRUE
+"221305_s_at",0.757950630724418,0.25447030989257,1.16990477481794,-5.29417056454614,1.35393697917013,"UGT1A3///UGT1A1///UGT1A9///UGT1A5///UGT1A8","UDP glucuronosyltransferase family 1 member A3///UDP glucuronosyltransferase family 1 member A1///UDP glucuronosyltransferase family 1 member A9///UDP glucuronosyltransferase family 1 member A5///UDP glucuronosyltransferase family 1 member A8",TRUE
+"232654_s_at",0.661974206478491,0.129788331504437,1.57344274840262,-4.80082704689511,1.32628577303987,"UGT1A6","UDP glucuronosyltransferase family 1 member A6",TRUE
+"207958_at",0.784789297644843,0.309196675794116,1.04079186860367,-5.42541218482101,0.391485580432498,"UGT2A2///UGT2A1","UDP glucuronosyltransferase family 2 member A2///UDP glucuronosyltransferase family 2 member A1 complex locus",TRUE
+"219948_x_at",0.91876780831279,0.654618366970541,0.45347290223642,-5.84001825232042,0.486504547131982,"UGT2A3","UDP glucuronosyltransferase family 2 member A3",TRUE
+"207392_x_at",0.904722110947821,0.609171281068735,-0.518613653927985,-5.80952520496749,-0.557882509299287,"UGT2B15","UDP glucuronosyltransferase family 2 member B15",TRUE
+"217175_at",0.9802233499944,0.907054094416123,-0.118098026678886,-5.93289262352466,-0.0881964157198483,"UGT2B15","UDP glucuronosyltransferase family 2 member B15",TRUE
+"216687_x_at",0.988713664405312,0.945559118090465,-0.0690628253688039,-5.93736061547159,-0.0952884434366963,"UGT2B15","UDP glucuronosyltransferase family 2 member B15",TRUE
+"207245_at",0.908230970990122,0.618842918944051,-0.504568997922842,-5.81643714759101,-0.708568270170249,"UGT2B17","UDP glucuronosyltransferase family 2 member B17",TRUE
+"211682_x_at",0.831875452294783,0.407216382187561,-0.84486616395741,-5.59787304244209,-0.982249290253603,"UGT2B28","UDP glucuronosyltransferase family 2 member B28",TRUE
+"206505_at",0.888750194607196,0.555453904949374,-0.598686448175318,-5.76659948349164,-0.836295285177025,"UGT2B4","UDP glucuronosyltransferase family 2 member B4",TRUE
+"236597_at",0.826617572584789,0.394857517008656,0.867703653048305,-5.5794752869204,0.405565183769788,"UGT3A1","UDP glycosyltransferase family 3 member A1",TRUE
+"235904_at",0.928354971916916,0.685496971673155,0.410340650797298,-5.85800316696782,0.258071779256428,"UGT3A1","UDP glycosyltransferase family 3 member A1",TRUE
+"237572_at",0.94895689004559,0.767700392485011,0.299034724705688,-5.89622304240346,0.23497648994304,"UGT3A1","UDP glycosyltransferase family 3 member A1",TRUE
+"208358_s_at",0.524670355423619,0.0391043749126886,2.19284501471558,-3.83505518750607,2.86398530245977,"UGT8","UDP glycosyltransferase 8",TRUE
+"228956_at",0.584828007864693,0.0650638123805159,1.94116603976067,-4.25418863665336,2.68173158300577,"UGT8","UDP glycosyltransferase 8",TRUE
+"224691_at",0.716472449896956,0.192381112451566,-1.34453035367235,-5.09557408068269,-0.39848340872425,"UHMK1","U2AF homology motif (UHM) kinase 1",TRUE
+"235003_at",0.837368340567858,0.420432250196997,-0.820928595894172,-5.61666500549424,-0.506635687204261,"UHMK1","U2AF homology motif (UHM) kinase 1",TRUE
+"227740_at",0.841967750949524,0.43439817982704,-0.79614028098006,-5.63559104744005,-0.432035629462623,"UHMK1","U2AF homology motif (UHM) kinase 1",TRUE
+"1552656_s_at",0.88698237223329,0.550948557675843,-0.605577796592366,-5.76262684169482,-0.254390973824504,"UHMK1","U2AF homology motif (UHM) kinase 1",TRUE
+"225655_at",0.920389295526597,0.661223230561806,-0.444176087704859,-5.84404381610292,-0.175784451601718,"UHRF1","ubiquitin like with PHD and ring finger domains 1",TRUE
+"233245_at",0.712975827977365,0.18737442018389,1.36043012892898,-5.07633181768755,0.396640829184089,"UHRF1BP1","UHRF1 binding protein 1",TRUE
+"226135_at",0.812896635201594,0.361598293558822,0.931571680578858,-5.52561245802409,0.346423714615167,"UHRF1BP1","UHRF1 binding protein 1",TRUE
+"1568789_at",0.945498722604777,0.754255800021289,0.316940495798784,-5.89087545047552,0.10584955415554,"UHRF1BP1","UHRF1 binding protein 1",TRUE
+"213118_at",0.637485146909712,0.108653637338443,-1.67167465535557,-4.66317686111636,-0.953563223591763,"UHRF1BP1L","UHRF1 binding protein 1 like",TRUE
+"213120_at",0.748437803638032,0.240956990081019,-1.20489271445768,-5.25628627620066,-0.531164701151683,"UHRF1BP1L","UHRF1 binding protein 1 like",TRUE
+"1554291_at",0.80168976994612,0.339004434954811,-0.977231648135583,-5.48495278665258,-0.509739301707354,"UHRF1BP1L","UHRF1 binding protein 1 like",TRUE
+"1554292_a_at",0.811598593104225,0.355826792415206,-0.943047419429612,-5.51556115884769,-0.587282180562633,"UHRF1BP1L","UHRF1 binding protein 1 like",TRUE
+"1562098_at",0.997763494670794,0.989063961349253,-0.0138622294668598,-5.93958988644666,-0.00517837504788954,"UHRF1BP1L","UHRF1 binding protein 1 like",TRUE
+"225610_at",0.740610299769501,0.230211567575252,1.23378335406962,-5.22427440396803,0.53265245664101,"UHRF2","ubiquitin like with PHD and ring finger domains 2",TRUE
+"220746_s_at",0.867522420064266,0.500108626575319,-0.685548214974044,-5.71333174659389,-0.25832100127478,"UIMC1","ubiquitin interaction motif containing 1",TRUE
+"221323_at",0.895457620469779,0.574236335286378,-0.57026436175028,-5.78251914666136,-0.21087535637814,"ULBP1","UL16 binding protein 1",TRUE
+"221291_at",0.783297797848606,0.305914220680852,1.04804982148759,-5.41839790410961,0.858235344285084,"ULBP2","UL16 binding protein 2",TRUE
+"238542_at",0.864894115958506,0.493198029023189,0.696761551885655,-5.70595227201445,0.606812114926036,"ULBP2","UL16 binding protein 2",TRUE
+"231748_at",0.994471114396429,0.974494002906668,-0.0323355243098863,-5.93917422712633,-0.0271806123557274,"ULBP3","UL16 binding protein 3",TRUE
+"209333_at",0.52645337190204,0.0397371700363738,-2.18510600348898,-3.84842670992364,-1.03791027885621,"ULK1","unc-51 like autophagy activating kinase 1",TRUE
+"204063_s_at",0.710372201621696,0.183163671070825,1.37406380056197,-5.05968180448406,0.507861601946612,"ULK2","unc-51 like autophagy activating kinase 2",TRUE
+"1554112_a_at",0.728385463227073,0.209607114284482,1.29218867484984,-5.15757222017826,0.545446467866554,"ULK2","unc-51 like autophagy activating kinase 2",TRUE
+"204062_s_at",0.782042580063933,0.303705717466804,1.05296422201796,-5.4136236221397,0.671033314533849,"ULK2","unc-51 like autophagy activating kinase 2",TRUE
+"215154_at",0.986342822130003,0.93532684983554,0.0820713906010734,-5.93640329565612,0.0554217019352263,"ULK2","unc-51 like autophagy activating kinase 2",TRUE
+"225067_at",0.593337376134677,0.0700322025064647,-1.90360064221182,-4.31380306465744,-1.02372078497073,"ULK3","unc-51 like kinase 3",TRUE
+"244168_s_at",0.741186481976394,0.231527198747031,-1.23019192989645,-5.22828950291868,-0.815963273779463,"ULK4","unc-51 like kinase 4",TRUE
+"220958_at",0.871708868449496,0.513291555229291,0.664397716119477,-5.7269391212799,0.494414803227786,"ULK4","unc-51 like kinase 4",TRUE
+"232206_at",0.932091525948902,0.700378963656809,0.389837375378545,-5.86593280896162,0.322945477549705,"ULK4","unc-51 like kinase 4",TRUE
+"231149_s_at",0.955892698633978,0.799924822537859,0.256508671853206,-5.90768705012637,0.154024427919637,"ULK4","unc-51 like kinase 4",TRUE
+"226596_x_at",0.942450624660433,0.741404759340949,0.334155082674905,-5.88544405306709,0.117064201334589,"UMAD1","UBAP1-MVB12-associated (UMA) domain containing 1",TRUE
+"206716_at",0.859696489664632,0.477920481924117,0.721876082454424,-5.68901054857471,0.463305241544504,"UMOD","uromodulin",TRUE
+"1553183_at",0.961212424803935,0.823206826973344,0.226086391149607,-5.91481784260969,0.224530844225164,"UMODL1","uromodulin like 1",TRUE
+"1553282_at",0.835952408568777,0.417046663430959,-0.827014997237073,-5.6119348329078,-0.558360122792838,"UMODL1-AS1","UMODL1 antisense RNA 1",TRUE
+"239800_at",0.17454705536906,0.00154833693377219,-3.60786589978542,-1.04189390433242,-2.23448800293384,"UMPS","uridine monophosphate synthetase",TRUE
+"202706_s_at",0.70772084164277,0.179354000581659,-1.38661439101838,-5.04423255114524,-0.416300578830654,"UMPS","uridine monophosphate synthetase",TRUE
+"215165_x_at",0.811356205298334,0.35549792874489,-0.943705073740721,-5.51498171476792,-0.29467380125811,"UMPS","uridine monophosphate synthetase",TRUE
+"202707_at",0.852006864319744,0.457311006651082,-0.756512736887147,-5.664711084003,-0.231448313372205,"UMPS","uridine monophosphate synthetase",TRUE
+"203271_s_at",0.944963505981344,0.752358684604302,-0.319475507181358,-5.89009347846197,-0.300926976867643,"UNC119","unc-119 lipid binding chaperone",TRUE
+"202365_at",0.897011777275924,0.582342867155932,-0.55814374469408,-5.78907994428786,-0.220410831562484,"UNC119B","unc-119 lipid binding chaperone B",TRUE
+"236272_at",0.943464796017993,0.746717994828573,-0.327025558463836,-5.88772798541548,-0.21876261823168,"UNC119B","unc-119 lipid binding chaperone B",TRUE
+"214817_at",0.842224301155785,0.435717560251628,-0.793824213056186,-5.6373315264835,-0.566705328255315,"UNC13A","unc-13 homolog A",TRUE
+"227453_at",0.984161165881616,0.922701305106751,-0.0981428676039857,-5.93499316642211,-0.0872765648505949,"UNC13A","unc-13 homolog A",TRUE
+"202893_at",0.657015752622694,0.125241960144911,-1.59337978486914,-4.7734122094798,-0.745000114822837,"UNC13B","unc-13 homolog B",TRUE
+"1569969_a_at",0.666354937030012,0.133171609880963,1.55897898178277,-4.82054629378772,1.66565498096372,"UNC13C","unc-13 homolog C",TRUE
+"1562074_a_at",0.770957614026379,0.279490642297519,1.10860257944424,-5.3581803985415,0.79859164105576,"UNC13C","unc-13 homolog C",TRUE
+"1556095_at",0.871165715950006,0.511826540311307,0.666733009838501,-5.72545673689476,0.751419973525759,"UNC13C","unc-13 homolog C",TRUE
+"1556096_s_at",0.951318915881544,0.777184490455984,0.286463731005141,-5.89979321395267,0.314787088063069,"UNC13C","unc-13 homolog C",TRUE
+"228352_at",0.64513208805899,0.115950720569995,1.63607779195687,-4.71379929084246,2.3335536489558,"UNC13D","unc-13 homolog D",TRUE
+"226678_at",0.855405088766616,0.468417137262404,0.737735345059636,-5.67801848374828,0.902024745151341,"UNC13D","unc-13 homolog D",TRUE
+"228350_at",0.994536266629158,0.974709252058286,0.0320625415318171,-5.93918278905542,0.0121393435295878,"UNC13D","unc-13 homolog D",TRUE
+"207499_x_at",0.818301707836664,0.371397473799119,-0.912365028474663,-5.54218163846392,-0.261105634331324,"UNC45A","unc-45 myosin chaperone A",TRUE
+"221708_s_at",0.846506765330126,0.44462356696394,-0.778302018339828,-5.64887288755559,-0.199040238359025,"UNC45A","unc-45 myosin chaperone A",TRUE
+"235261_at",0.99691938672319,0.98437592673349,-0.0198053467289267,-5.93949243118537,-0.0181816329429223,"UNC45B","unc-45 myosin chaperone B",TRUE
+"203583_at",0.822452640841017,0.387288608271518,-0.881918494928554,-5.56779360438199,-0.254171345877467,"UNC50","unc-50 inner nuclear membrane RNA binding protein",TRUE
+"243833_at",0.608709711882903,0.0813935993221825,1.82577124238299,-4.43470392323395,0.881109288612367,"UNC5A","unc-5 netrin receptor A",TRUE
+"236448_at",0.70939075283402,0.182407886076651,-1.37653709148584,-5.05664651547529,-1.47149276567497,"UNC5A","unc-5 netrin receptor A",TRUE
+"213100_at",0.677178016653513,0.144708088897586,1.51183684311448,-4.88381645771073,1.32709459338997,"UNC5B","unc-5 netrin receptor B",TRUE
+"226899_at",0.709135917979769,0.181748909348889,1.37870021486441,-5.05398815489723,1.3330814801085,"UNC5B","unc-5 netrin receptor B",TRUE
+"41856_at",0.839519981963042,0.427659928006875,0.808037156398602,-5.62657568050266,0.39352435605999,"UNC5B","unc-5 netrin receptor B",TRUE
+"239136_at",0.478691006415319,0.0267460142657457,2.3728253165062,-3.51620393905325,1.25358690187208,"UNC5B-AS1","UNC5B antisense RNA 1",TRUE
+"1555341_at",0.180622515496298,0.00167390171878626,3.57558345726841,-1.11056334255585,3.05848687829201,"UNC5C","unc-5 netrin receptor C",TRUE
+"240958_at",0.636147339487472,0.107412630875384,1.67792816538008,-4.65419813319305,0.829881116762941,"UNC5C","unc-5 netrin receptor C",TRUE
+"1555342_a_at",0.653793326711711,0.123063025065339,1.60314931349064,-4.75988023855367,1.25371282629398,"UNC5C","unc-5 netrin receptor C",TRUE
+"206189_at",0.855463536305195,0.468711298636634,-0.737241616858655,-5.67836410683667,-0.58554542274246,"UNC5C","unc-5 netrin receptor C",TRUE
+"227838_at",0.92777930247318,0.683190004314915,-0.413534870343593,-5.85673179631017,-0.363940063948485,"UNC5C","unc-5 netrin receptor C",TRUE
+"231008_at",0.954449231029359,0.790958901807326,0.268289007194945,-5.90468585025335,0.123383378012569,"UNC5CL","unc-5 family C-terminal like",TRUE
+"231325_at",0.647518308302168,0.118620227801675,1.62352524952871,-4.73145092670933,1.1348956528965,"UNC5D","unc-5 netrin receptor D",TRUE
+"229550_at",0.997263441064271,0.986024180823395,0.0177157492742809,-5.93953061822676,0.0125687224235511,"UNC79","unc-79 homolog (C. elegans)",TRUE
+"243836_at",0.787983178144695,0.314020678989495,1.03022341964539,-5.43554730318203,0.492947319020049,"UNC80","unc-80 homolog, NALCN activator",TRUE
+"237660_at",0.864829185767069,0.492739526711979,-0.697508694998005,-5.7054565179707,-0.573092628696751,"UNC80","unc-80 homolog, NALCN activator",TRUE
+"230220_at",0.973071267819624,0.870502766516052,0.164919455522352,-5.92644480595461,0.130512677622825,"UNC80","unc-80 homolog, NALCN activator",TRUE
+"214640_at",0.593339168375633,0.0703605823772666,1.90120114557748,-4.31758345987074,1.54594735359965,"UNC93A","unc-93 homolog A (C. elegans)",TRUE
+"214382_at",0.948109877411639,0.764258245129762,-0.30360931206332,-5.89488613596918,-0.226015757514421,"UNC93A","unc-93 homolog A (C. elegans)",TRUE
+"225869_s_at",0.639656559005154,0.110024859940038,1.66483480197097,-4.67296830216622,0.991002725785568,"UNC93B1","unc-93 homolog B1 (C. elegans)",TRUE
+"220998_s_at",0.793626533839716,0.325390507710744,1.00575737848133,-5.45865146135897,0.633689429888097,"UNC93B1","unc-93 homolog B1 (C. elegans)",TRUE
+"227483_s_at",0.871165715950006,0.511744982234284,0.666863126170696,-5.72537399584328,0.382990047359353,"UNC93B1","unc-93 homolog B1 (C. elegans)",TRUE
+"202330_s_at",0.972644208712919,0.867668013457044,-0.168565146526159,-5.92585343609925,-0.0546753154564037,"UNG","uracil DNA glycosylase",TRUE
+"216586_at",0.954577684533304,0.792701300859978,-0.265996681137051,-5.90528033888865,-0.2094836294901,"UNGP2","uracil-DNA glycosylase pseudogene 2",TRUE
+"226376_at",0.958794064221941,0.813539617022053,0.238690255548428,-5.91197204971097,0.073783502918463,"UNK","unkempt family zinc finger",TRUE
+"1562434_at",0.97689149311934,0.89008848663855,0.139790477227683,-5.93017007593158,0.0506241644775693,"UNK","unkempt family zinc finger",TRUE
+"228357_at",0.993819570187391,0.970740417139648,0.037096311744589,-5.93901323770071,0.0141342427247082,"UNK","unkempt family zinc finger",TRUE
+"229908_s_at",0.839508810008021,0.426195629435622,-0.810637855360098,-5.62458816495676,-0.38316066494521,"UNKL","unkempt family like zinc finger",TRUE
+"221064_s_at",0.847527520228882,0.446356743392605,-0.775303442260235,-5.65107768524751,-0.264015153490332,"UNKL","unkempt family like zinc finger",TRUE
+"235087_at",0.959357995170594,0.81638865004668,-0.234971741679181,-5.91282760964658,-0.168849150874166,"UNKL","unkempt family like zinc finger",TRUE
+"224043_s_at",0.627053909308516,0.0978895799807148,-1.72806962976995,-4.58129443250544,-1.32312707552198,"UPB1","beta-ureidopropionase 1",TRUE
+"220507_s_at",0.701017355736987,0.172770166777429,-1.40881301979059,-5.01662255936159,-1.21791729857328,"UPB1","beta-ureidopropionase 1",TRUE
+"224042_at",0.89961817630669,0.590616880182129,0.545859240608711,-5.79558985399534,0.175191626889119,"UPB1","beta-ureidopropionase 1",TRUE
+"228219_s_at",0.909253608893833,0.62326453478539,0.498182416734771,-5.81951900575605,0.319680313896668,"UPB1","beta-ureidopropionase 1",TRUE
+"211168_s_at",0.854400503339099,0.465947138693405,-0.741888320310996,-5.67510260217813,-0.189048064824028,"UPF1","UPF1, RNA helicase and ATPase",TRUE
+"208947_s_at",0.995056793893123,0.976893708748078,-0.0292923125337679,-5.9392655699499,-0.0101591716765448,"UPF1","UPF1, RNA helicase and ATPase",TRUE
+"203519_s_at",0.668235254207051,0.134426692489421,1.55369068759687,-4.82772032710965,0.433221080877688,"UPF2","UPF2 regulator of nonsense transcripts homolog (yeast)",TRUE
+"217596_at",0.614411830126793,0.0853539129329208,1.80085654788794,-4.47264336049537,1.02239663773228,"UPF3A","UPF3 regulator of nonsense transcripts homolog A (yeast)",TRUE
+"206959_s_at",0.67606695078322,0.142581888208675,1.52028707753812,-4.87258888997317,0.461545777292542,"UPF3A","UPF3 regulator of nonsense transcripts homolog A (yeast)",TRUE
+"206958_s_at",0.681732274610686,0.149341555699938,1.49376812015238,-4.90765571079459,0.573430028577095,"UPF3A","UPF3 regulator of nonsense transcripts homolog A (yeast)",TRUE
+"214323_s_at",0.703902004301726,0.175551782308873,1.39935343164746,-5.02843239250586,0.511827455615441,"UPF3A","UPF3 regulator of nonsense transcripts homolog A (yeast)",TRUE
+"240993_at",0.695744345349551,0.165241762755408,1.43504099182878,-4.98353652701812,0.441002010905554,"UPF3B","UPF3 regulator of nonsense transcripts homolog B (yeast)",TRUE
+"218757_s_at",0.901850934242229,0.599864891185865,-0.532228347227879,-5.8026484368979,-0.235510128550736,"UPF3B","UPF3 regulator of nonsense transcripts homolog B (yeast)",TRUE
+"214624_at",0.981452314383709,0.911911459039905,0.111898474375626,-5.93358667209619,0.074478319737799,"UPK1A","uroplakin 1A",TRUE
+"210064_s_at",0.074696899507382,0.000243183321670123,4.36622341239922,0.590359348429372,3.59379099906029,"UPK1B","uroplakin 1B",TRUE
+"210065_s_at",0.0933337461142551,0.000377261232578882,4.18709000206294,0.203292251148331,4.46913267418661,"UPK1B","uroplakin 1B",TRUE
+"207862_at",0.319419989704434,0.00705148472927757,2.96892087849574,-2.37067747855716,1.54889686228203,"UPK2","uroplakin 2",TRUE
+"206771_at",0.873714994839466,0.519477481098561,-0.654577684413021,-5.73311805073408,-0.439208769455169,"UPK3A","uroplakin 3A",TRUE
+"206658_at",0.268558783291603,0.00414195880915786,3.19639965414199,-1.90627565196553,3.00863228883545,"UPK3B","uroplakin 3B",TRUE
+"1552622_s_at",0.501591596209182,0.0321695318608596,2.28606629659386,-3.67174891094742,0.851753855666393,"UPK3BL///POLR2J3///LOC441259///POLR2J2///POLR2J","uroplakin 3B-like///RNA polymerase II subunit J3///PMS1 homolog 2, mismatch repair system component pseudogene///RNA polymerase II subunit J2///RNA polymerase II subunit J",TRUE
+"1552621_at",0.491581666454407,0.0294814135217924,2.32723138607842,-3.59836121504435,0.8113756135211,"UPK3BL///POLR2J3///POLR2J2///POLR2J","uroplakin 3B-like///RNA polymerase II subunit J3///RNA polymerase II subunit J2///RNA polymerase II subunit J",TRUE
+"214740_at",0.763044089435492,0.26281764655606,1.14897845459953,-5.31636209614662,0.761397471443179,"UPK3BL///POLR2J3///POLR2J2///POLR2J","uroplakin 3B-like///RNA polymerase II subunit J3///RNA polymerase II subunit J2///RNA polymerase II subunit J",TRUE
+"216242_x_at",0.545992239117952,0.0472420182460932,2.10094358424811,-3.9919285178032,1.09102612008901,"UPK3BL///POLR2J3///POLR2J2///POLR2J4///POLR2J","uroplakin 3B-like///RNA polymerase II subunit J3///RNA polymerase II subunit J2///RNA polymerase II subunit J4, pseudogene///RNA polymerase II subunit J",TRUE
+"203234_at",0.623852759019384,0.0955245215465293,1.74116453540841,-4.56199119333294,2.1982398133368,"UPP1","uridine phosphorylase 1",TRUE
+"233155_at",0.774479064996015,0.290895022821497,1.08198470305299,-5.38502278845931,0.452117017334566,"UPP2","uridine phosphorylase 2",TRUE
+"231376_at",0.799805845161581,0.335208979275311,-0.985103727485879,-5.47776332525368,-0.638106104099828,"UPP2","uridine phosphorylase 2",TRUE
+"226199_at",0.466300647363886,0.0243570514603545,-2.41631121085912,-3.43701537526017,-1.1185040979949,"UPRT","uracil phosphoribosyltransferase homolog",TRUE
+"222470_s_at",0.668587404382295,0.134881565818183,-1.55178414866002,-4.83030199871136,-0.870967099614058,"UQCC1","ubiquinol-cytochrome c reductase complex assembly factor 1",TRUE
+"217935_s_at",0.811484718925723,0.355643289161375,-0.943414334629038,-5.51523792400611,-0.484627316197468,"UQCC1","ubiquinol-cytochrome c reductase complex assembly factor 1",TRUE
+"229672_at",0.916349280948806,0.646587273247865,-0.464832271658729,-5.83498866400201,-0.246543106507656,"UQCC1","ubiquinol-cytochrome c reductase complex assembly factor 1",TRUE
+"244795_at",0.937113154905832,0.71943924940932,0.363822453837792,-5.87541734580008,0.279107558864308,"UQCC1","ubiquinol-cytochrome c reductase complex assembly factor 1",TRUE
+"229443_at",0.918134635422754,0.652211398571206,-0.456870953734815,-5.83852647938296,-0.162302802087269,"UQCC2","ubiquinol-cytochrome c reductase complex assembly factor 2",TRUE
+"229099_at",0.694505490882266,0.16388944364751,-1.43985353401255,-4.97741137493179,-0.638815457270354,"UQCC3","ubiquinol-cytochrome c reductase complex assembly factor 3",TRUE
+"228142_at",0.527826453640453,0.0404411184791978,-2.1766269726363,-3.86304335424507,-0.75436931153962,"UQCR10","ubiquinol-cytochrome c reductase, complex III subunit X",TRUE
+"218190_s_at",0.699161781955613,0.170600827160919,-1.41627522776679,-5.00726014365034,-0.358351601438143,"UQCR10","ubiquinol-cytochrome c reductase, complex III subunit X",TRUE
+"202090_s_at",0.625618384908995,0.09682992487336,-1.73390293598593,-4.57270890581358,-0.472774274443051,"UQCR11","ubiquinol-cytochrome c reductase, complex III subunit XI",TRUE
+"223613_at",0.86333554038125,0.487668126733141,0.705799453547957,-5.69992132385374,0.272066982128305,"UQCR11","ubiquinol-cytochrome c reductase, complex III subunit XI",TRUE
+"209066_x_at",0.474859593446097,0.0260783219518181,-2.38460583199251,-3.49483032778675,-0.765626924203097,"UQCRB","ubiquinol-cytochrome c reductase binding protein",TRUE
+"209065_at",0.490107603095446,0.0292426328692986,-2.33105281034527,-3.5915101565316,-0.926846971113436,"UQCRB","ubiquinol-cytochrome c reductase binding protein",TRUE
+"244293_at",0.53124345566328,0.0416347180158602,-2.16255088077126,-3.88723070788368,-1.17599510129856,"UQCRB","ubiquinol-cytochrome c reductase binding protein",TRUE
+"205849_s_at",0.763044089435492,0.262843892206511,-1.14891343877868,-5.31643049459784,-0.324083908800318,"UQCRB","ubiquinol-cytochrome c reductase binding protein",TRUE
+"201903_at",0.831487912516861,0.405971092979523,-0.847146994584932,-5.59605617673756,-0.262585517058346,"UQCRC1","ubiquinol-cytochrome c reductase core protein I",TRUE
+"200883_at",0.8920930097751,0.56394032151988,-0.585784314511868,-5.77391900062681,-0.258837734725411,"UQCRC2","ubiquinol-cytochrome c reductase core protein II",TRUE
+"212600_s_at",0.899331416659389,0.590026109431941,-0.546733530849053,-5.79513119352934,-0.191370827578462,"UQCRC2","ubiquinol-cytochrome c reductase core protein II",TRUE
+"241755_at",0.97689149311934,0.890003901952451,-0.139898791728571,-5.93015533454067,-0.0613726271538821,"UQCRC2","ubiquinol-cytochrome c reductase core protein II",TRUE
+"208909_at",0.816800680706682,0.36865642087592,-0.917703218721571,-5.53760840095881,-0.263458550966078,"UQCRFS1","ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1",TRUE
+"202233_s_at",0.99187501204911,0.962641790459306,-0.0473711896711887,-5.93859055576642,-0.0122129941998725,"UQCRHL///UQCRH","ubiquinol-cytochrome c reductase hinge protein like///ubiquinol-cytochrome c reductase hinge protein",TRUE
+"201568_at",0.707898177720919,0.179745479691533,-1.38531500226359,-5.04583745161385,-0.387461302598211,"UQCRQ","ubiquinol-cytochrome c reductase complex III subunit VII",TRUE
+"217633_at",0.797508583262597,0.331110102241627,-0.993674357844256,-5.46987621822604,-0.65764997567575,"URB1","URB1 ribosome biogenesis 1 homolog (S. cerevisiae)",TRUE
+"208395_s_at",0.909052380289506,0.622556020515411,-0.499204375811181,-5.81902843256652,-0.302595714057988,"URB1","URB1 ribosome biogenesis 1 homolog (S. cerevisiae)",TRUE
+"212996_s_at",0.983326118527016,0.918680230615876,0.10326678564721,-5.93449075982518,0.0328683938534651,"URB1","URB1 ribosome biogenesis 1 homolog (S. cerevisiae)",TRUE
+"227424_x_at",0.605484070618809,0.0790811476596052,-1.84080918110743,-4.4116233930368,-0.760255853521839,"URB1-AS1","URB1 antisense RNA 1 (head to head)",TRUE
+"205284_at",0.89316156038085,0.567303913295261,0.580698314472349,-5.77676195575186,0.186827652396758,"URB2","URB2 ribosome biogenesis 2 homolog (S. cerevisiae)",TRUE
+"218601_at",0.734730148360473,0.219580794774937,1.26339250685279,-5.19078903130655,0.345939109056173,"URGCP","upregulator of cell proliferation",TRUE
+"244046_at",0.835513930382091,0.414895874425651,0.830897736929493,-5.60890019768899,0.393179714027695,"URGCP","upregulator of cell proliferation",TRUE
+"224948_at",0.870808709484996,0.510285393343171,0.66919368893573,-5.72388937054188,0.170074374151971,"URGCP-MRPS24///MRPS24","URGCP-MRPS24 readthrough///mitochondrial ribosomal protein S24",TRUE
+"1556231_a_at",0.635174103121116,0.106051415972302,1.68485812733903,-4.64421851820717,0.792721535671049,"URI1","URI1, prefoldin like chaperone",TRUE
+"211563_s_at",0.893172664248402,0.56754649659475,0.580332109261326,-5.77696572990108,0.323267412035779,"URI1","URI1, prefoldin like chaperone",TRUE
+"214173_x_at",0.901797819916539,0.599813068478918,0.532304444135234,-5.80260951300176,0.288900205899258,"URI1","URI1, prefoldin like chaperone",TRUE
+"210157_at",0.962646556512271,0.830032859874861,-0.217209408132153,-5.91672996879166,-0.148942171655035,"URI1","URI1, prefoldin like chaperone",TRUE
+"208101_s_at",0.7168525499531,0.192852019337177,-1.3430517043289,-5.0973539482508,-0.456950187119501,"URM1","ubiquitin related modifier 1",TRUE
+"228626_at",0.990571290227394,0.952180424859459,-0.0606516225141961,-5.93789191973387,-0.0294268095209089,"URM1","ubiquitin related modifier 1",TRUE
+"1553341_at",0.971216837324271,0.862577541885748,-0.175117759202699,-5.92475811937535,-0.12900382445202,"UROC1","urocanate hydratase 1",TRUE
+"208971_at",0.778006206647445,0.297138429478032,-1.06772964911359,-5.39915868838452,-0.45531538105422,"UROD","uroporphyrinogen decarboxylase",TRUE
+"222074_at",0.819203514175924,0.376091950787926,-0.903282872945414,-5.54990574927737,-0.242458682692582,"UROD","uroporphyrinogen decarboxylase",TRUE
+"208970_s_at",0.843475287501313,0.438776847318012,-0.788470448417667,-5.64133650898998,-0.275464965320644,"UROD","uroporphyrinogen decarboxylase",TRUE
+"203031_s_at",0.7717895132349,0.281423239849743,-1.10403726885551,-5.36282542406187,-0.399362245524028,"UROS","uroporphyrinogen III synthase",TRUE
+"1568781_at",0.84204847460846,0.435277842484845,-0.794595621537302,-5.63675235811158,-0.316386784713111,"UROS","uroporphyrinogen III synthase",TRUE
+"232560_at",0.968066640321622,0.850022014706218,0.19131386672193,-5.9218721925032,0.0855309702582812,"UROS","uroporphyrinogen III synthase",TRUE
+"218060_s_at",0.719796748665147,0.195671496578145,1.33425732049001,-5.10790589010345,0.702862585837023,"USB1","U6 snRNA biogenesis phosphodiesterase 1",TRUE
+"1554016_a_at",0.790240875783718,0.319644287253866,1.01804627347548,-5.44710938398093,0.425432783054967,"USB1","U6 snRNA biogenesis phosphodiesterase 1",TRUE
+"1554119_at",0.834881450121645,0.413646156421495,0.833159648488795,-5.6071262258077,0.323389115871099,"USB1","U6 snRNA biogenesis phosphodiesterase 1",TRUE
+"221706_s_at",0.806649582904638,0.34770643582961,-0.959408104617519,-5.50103624145398,-0.348231204714949,"USE1","unconventional SNARE in the ER 1",TRUE
+"219348_at",0.819018525257656,0.373497825860374,0.90829225705548,-5.54565423546212,0.344138555520768,"USE1","unconventional SNARE in the ER 1",TRUE
+"231768_at",0.966769992359004,0.845333611140506,0.197374927251373,-5.92072682272643,0.104374394037611,"USF1","upstream transcription factor 1",TRUE
+"202152_x_at",0.620912785033482,0.0908078143467617,-1.76813113991043,-4.52190068380152,-0.684589434842716,"USF2","upstream transcription factor 2, c-fos interacting",TRUE
+"214879_x_at",0.823074246722209,0.389515962987595,-0.877716801714512,-5.57126487856194,-0.304300350492021,"USF2","upstream transcription factor 2, c-fos interacting",TRUE
+"215737_x_at",0.93423034725099,0.708805904680547,-0.378302932228398,-5.87021773782659,-0.110812348348036,"USF2","upstream transcription factor 2, c-fos interacting",TRUE
+"242513_x_at",0.784708646973769,0.308536796103166,1.04224656019357,-5.42400984574181,0.47342974058872,"USF3","upstream transcription factor family member 3",TRUE
+"242508_at",0.904701596964947,0.609074734022546,-0.518754383783635,-5.80945501020655,-0.152106687407829,"USF3","upstream transcription factor family member 3",TRUE
+"1559601_at",0.952670965982815,0.783307238696981,0.278373239120369,-5.90201047173484,0.179088957220873,"USF3","upstream transcription factor family member 3",TRUE
+"227435_at",0.959131001044522,0.814641861550869,0.237251217862873,-5.91230472992351,0.08689293893719,"USF3","upstream transcription factor family member 3",TRUE
+"227433_at",0.966121760063838,0.842341551024109,-0.20124693739769,-5.91997649337405,-0.06988002489358,"USF3","upstream transcription factor family member 3",TRUE
+"221173_at",0.358427723880268,0.0100862016139375,2.81312474982453,-2.68125521840344,1.85184211547954,"USH1C","USH1 protein network component harmonin",TRUE
+"211184_s_at",0.716472449896956,0.192345365969093,1.34464271380927,-5.09543876435798,0.625865224612066,"USH1C","USH1 protein network component harmonin",TRUE
+"205137_x_at",0.91202803207519,0.631310447184314,0.486614327829971,-5.82500358715589,0.285725327831723,"USH1C","USH1 protein network component harmonin",TRUE
+"1553263_at",0.745717401914776,0.237372317136943,1.21442039222553,-5.24580182653633,0.638251589851448,"USH1G","USH1 protein network component sans",TRUE
+"207706_at",0.947559391160104,0.761034763785744,-0.307899296454107,-5.89361412627803,-0.301230854943109,"USH2A","usherin",TRUE
+"235510_at",0.91679324405498,0.648387035411394,0.462281295568129,-5.83612877420334,0.16420944889291,"USHBP1","USH1 protein network component harmonin binding protein 1",TRUE
+"225413_at",0.94895689004559,0.767891743580928,-0.298780612506031,-5.89629671587259,-0.0807954273445493,"USMG5","up-regulated during skeletal muscle growth 5 homolog (mouse)",TRUE
+"201831_s_at",0.948989397056643,0.770039590314,0.295929668179167,-5.89711901910531,0.130377833014496,"USO1","USO1 vesicle transport factor",TRUE
+"201832_s_at",0.975265330414469,0.880528919683854,-0.152043106191638,-5.92843025908316,-0.0590897221679274,"USO1","USO1 vesicle transport factor",TRUE
+"202412_s_at",0.769258076576208,0.276636901751126,1.11538601459329,-5.35124711894478,0.395508721717524,"USP1","ubiquitin specific peptidase 1",TRUE
+"202413_s_at",0.807544796225587,0.348927347244931,0.956931823733619,-5.50324935765454,0.311806591943363,"USP1","ubiquitin specific peptidase 1",TRUE
+"209137_s_at",0.797508506396963,0.330945342592442,-0.994020392984596,-5.46955647567522,-0.335362427132976,"USP10","ubiquitin specific peptidase 10",TRUE
+"209136_s_at",0.940323871449272,0.733302418750441,-0.345061391582071,-5.88185597156493,-0.106981973724995,"USP10","ubiquitin specific peptidase 10",TRUE
+"208723_at",0.896229101808264,0.580030759260232,0.561592048208605,-5.78722731671567,0.217769674791942,"USP11","ubiquitin specific peptidase 11",TRUE
+"215886_x_at",0.557512088623721,0.0523300837127194,2.05048820671476,-4.07622518445379,0.525307293810446,"USP12","ubiquitin specific peptidase 12",TRUE
+"213327_s_at",0.836073870069938,0.417341162541358,0.826484332682828,-5.61234855150926,0.276327204094132,"USP12","ubiquitin specific peptidase 12",TRUE
+"227788_at",0.620912785033482,0.0908425401860781,1.76792825515396,-4.52220399919311,0.564395695027029,"USP13","ubiquitin specific peptidase 13 (isopeptidase T-3)",TRUE
+"226902_at",0.68270002258037,0.15055578424985,1.48910887054356,-4.91376564546136,0.593032443510971,"USP13","ubiquitin specific peptidase 13 (isopeptidase T-3)",TRUE
+"205356_at",0.74371414757151,0.234439970190541,1.22229536035996,-5.23708207683404,0.516235194722949,"USP13","ubiquitin specific peptidase 13 (isopeptidase T-3)",TRUE
+"226567_at",0.65623471946388,0.124477554194054,1.59679084471983,-4.76869479261983,0.805342266116599,"USP14","ubiquitin specific peptidase 14",TRUE
+"201671_x_at",0.67386596547729,0.140393364659384,1.5290936604291,-4.86083480953499,0.686566758836006,"USP14","ubiquitin specific peptidase 14",TRUE
+"201672_s_at",0.741716158050666,0.232194124576044,1.22837726298272,-5.2303144024641,0.385704231532538,"USP14","ubiquitin specific peptidase 14",TRUE
+"218386_x_at",0.769258076576208,0.275866106517997,1.11722695392759,-5.34935904716684,0.385668215183488,"USP16","ubiquitin specific peptidase 16",TRUE
+"222616_s_at",0.83766047465051,0.422179385421315,0.817799740972727,-5.61908392084434,0.260497410130226,"USP16","ubiquitin specific peptidase 16",TRUE
+"228822_s_at",0.950629206489271,0.774986659731985,0.289372646107524,-5.89898060209995,0.0993804465867054,"USP16","ubiquitin specific peptidase 16",TRUE
+"219211_at",0.883314886055456,0.541281791356232,0.62046498926237,-5.75389515279891,0.456510758814412,"USP18","ubiquitin specific peptidase 18",TRUE
+"214674_at",0.77204612088057,0.282398726501884,-1.10174154249185,-5.36515480250342,-0.440514153605081,"USP19","ubiquitin specific peptidase 19",TRUE
+"226357_at",0.783844746433788,0.306546471884339,-1.04664755776144,-5.41975650587204,-0.317437655859798,"USP19","ubiquitin specific peptidase 19",TRUE
+"207213_s_at",0.849398303368843,0.450493605010684,-0.768174733352976,-5.65628704286643,-0.652719108500055,"USP2","ubiquitin specific peptidase 2",TRUE
+"207211_at",0.895270475431143,0.573534996195597,0.571317022038524,-5.78194290163325,0.348705076946223,"USP2","ubiquitin specific peptidase 2",TRUE
+"229337_at",0.912329443373872,0.632775573911088,-0.484515101646265,-5.82598535943214,-0.285652734235875,"USP2","ubiquitin specific peptidase 2",TRUE
+"230965_at",0.977860524436236,0.892675543300057,0.136478455255563,-5.93061533338805,0.0837346640105245,"USP2","ubiquitin specific peptidase 2",TRUE
+"1564449_at",0.741260241503758,0.231870791052669,1.22925654033983,-5.22933358132149,0.797343970036413,"USP2-AS1","USP2 antisense RNA 1 (head to head)",TRUE
+"203965_at",0.787784580458053,0.313661956320839,-1.03100536030297,-5.43480061846912,-0.496474862931323,"USP20","ubiquitin specific peptidase 20",TRUE
+"234735_s_at",0.556381379241158,0.0519241290204682,-2.05434876249115,-4.06982242686155,-0.635727574951177,"USP21","ubiquitin specific peptidase 21",TRUE
+"218367_x_at",0.606138724709726,0.0798083450917247,-1.83603950316548,-4.41895866593326,-0.660235514196234,"USP21","ubiquitin specific peptidase 21",TRUE
+"232219_x_at",0.661974206478491,0.129340963234504,-1.57537860547305,-4.79817694490957,-0.51281221396483,"USP21","ubiquitin specific peptidase 21",TRUE
+"216964_at",0.692289844352812,0.161720955786956,1.44763779316051,-4.96746856860316,0.815589598855685,"USP22","ubiquitin specific peptidase 22",TRUE
+"220861_at",0.869698482173109,0.507251613446618,0.674049762817137,-5.72078000221247,0.495146537648118,"USP22","ubiquitin specific peptidase 22",TRUE
+"216957_at",0.93789466363241,0.725391362643249,0.35575153676989,-5.87822847638811,0.317985173697661,"USP22","ubiquitin specific peptidase 22",TRUE
+"200083_at",0.986342822130003,0.933729405829598,0.0841035170443042,-5.93623887479445,0.0197927276408354,"USP22","ubiquitin specific peptidase 22",TRUE
+"230004_at",0.908176111166321,0.618739097228083,0.504719212777076,-5.8163641999724,0.201487992510467,"USP24","ubiquitin specific peptidase 24",TRUE
+"212381_at",0.916057757219214,0.64589064413412,0.465820511283211,-5.8345453378177,0.166445209700735,"USP24","ubiquitin specific peptidase 24",TRUE
+"212388_at",0.956762870061999,0.80432412811156,0.250742060681043,-5.90910736214535,0.100920550380591,"USP24","ubiquitin specific peptidase 24",TRUE
+"220419_s_at",0.366569797255916,0.0108469241874801,2.78115302957743,-2.74412772207786,0.813077331595542,"USP25","ubiquitin specific peptidase 25",TRUE
+"1555559_s_at",0.517654151778308,0.036839365424223,2.22151053167988,-3.78527501641968,0.787329515534891,"USP25","ubiquitin specific peptidase 25",TRUE
+"223167_s_at",0.538128506818324,0.0437786117663997,2.13815988745568,-3.9289101210785,0.921716234678471,"USP25","ubiquitin specific peptidase 25",TRUE
+"1563497_at",0.690330257199992,0.159921774809238,1.45416051626638,-4.95910350909198,0.438739475162669,"USP25","ubiquitin specific peptidase 25",TRUE
+"1555558_at",0.980171602298162,0.906759572825625,-0.118474080501297,-5.93284932171894,-0.0940227719535618,"USP25","ubiquitin specific peptidase 25",TRUE
+"224532_at",0.565043084457947,0.0563169394263148,-2.01393083841484,-4.13646175626528,-1.56265830842535,"USP26","ubiquitin specific peptidase 26",TRUE
+"217605_at",0.821424121108148,0.382774740599989,-0.890482069258067,-5.56067114152281,-0.308174024624084,"USP27X","ubiquitin specific peptidase 27, X-linked",TRUE
+"230620_at",0.839519981963042,0.427562171155978,-0.808210606633174,-5.62644331231245,-0.227326808178369,"USP27X","ubiquitin specific peptidase 27, X-linked",TRUE
+"243017_at",0.958325326717984,0.811548622814255,0.241290911062372,-5.91136574897719,0.141781990598973,"USP27X-AS1","USP27X antisense RNA 1 (head to head)",TRUE
+"231837_at",0.51470556386048,0.0353146349773309,2.24172428647685,-3.74993673120616,0.658397853488394,"USP28","ubiquitin specific peptidase 28",TRUE
+"1552678_a_at",0.744931128252932,0.236671499707615,1.21629575750236,-5.24372970827819,0.334468054495121,"USP28","ubiquitin specific peptidase 28",TRUE
+"230623_x_at",0.807634612901073,0.348992690706918,0.956799458618878,-5.50336750844204,0.274581186077217,"USP28","ubiquitin specific peptidase 28",TRUE
+"220895_at",0.936992192746977,0.718336281194133,0.365320742890239,-5.87488863364865,0.239106903275673,"USP29","ubiquitin specific peptidase 29",TRUE
+"221654_s_at",0.6708432030569,0.136722807749902,-1.54412065096909,-4.84065398466274,-0.617543864128965,"USP3","ubiquitin specific peptidase 3",TRUE
+"226652_at",0.673729302435703,0.140333362214689,-1.52933669297802,-4.86050967013277,-0.526273818172909,"USP3","ubiquitin specific peptidase 3",TRUE
+"1562738_a_at",0.280199223932988,0.00463762056116989,-3.14843072650317,-2.00516022840084,-1.05631193482882,"USP3-AS1","USP3 antisense RNA 1",TRUE
+"227572_at",0.547195868806649,0.0475394750700252,-2.09786281978842,-3.99711351270309,-1.03508179634591,"USP30","ubiquitin specific peptidase 30",TRUE
+"223602_at",0.64513208805899,0.115790513271678,-1.6368388042722,-4.71272577935853,-0.682141893480885,"USP30","ubiquitin specific peptidase 30",TRUE
+"228675_at",0.481218714024581,0.0272420823626062,2.36424724432942,-3.5317299345354,1.06826294152662,"USP30-AS1","USP30 antisense RNA 1",TRUE
+"226033_at",0.735165878294211,0.22017328647584,1.2617137663005,-5.19270575269359,0.400100590828766,"USP31","ubiquitin specific peptidase 31",TRUE
+"226035_at",0.775341201891078,0.291902497298841,1.07966966916232,-5.38732986290279,0.425842143848811,"USP31","ubiquitin specific peptidase 31",TRUE
+"1558117_s_at",0.878278790222455,0.530832793314453,0.636717439725332,-5.74412956009125,0.178440282815705,"USP31","ubiquitin specific peptidase 31",TRUE
+"244441_at",0.933336329621599,0.705102095930867,-0.383366021007562,-5.86835247400584,-0.223536807082717,"USP31","ubiquitin specific peptidase 31",TRUE
+"227256_at",0.95168059103032,0.778348328234368,0.284924369275504,-5.90021994233606,0.0977616445003466,"USP31","ubiquitin specific peptidase 31",TRUE
+"244871_s_at",0.872668627020452,0.516296314075153,-0.659619579705481,-5.72995662458692,-0.396191657032093,"USP32","ubiquitin specific peptidase 32",TRUE
+"211702_s_at",0.937113154905832,0.719992304095666,-0.363071495314868,-5.87568153491104,-0.219191962821922,"USP32","ubiquitin specific peptidase 32",TRUE
+"226505_x_at",0.961561244483099,0.825983373290114,-0.22247340305755,-5.91560528763399,-0.124843333462668,"USP32","ubiquitin specific peptidase 32",TRUE
+"206405_x_at",0.612420348961838,0.0841449019888403,1.80835457606073,-4.46126516342316,0.661221406728664,"USP32///USP6","ubiquitin specific peptidase 32///ubiquitin specific peptidase 6",TRUE
+"242242_at",0.711989638658417,0.185881997569885,1.36523437123064,-5.07048045968576,0.519417570845651,"USP32///USP6","ubiquitin specific peptidase 32///ubiquitin specific peptidase 6",TRUE
+"1555065_x_at",0.784552021081681,0.307997687166291,1.04343664801763,-5.42286127691231,0.470189882835538,"USP32///USP6","ubiquitin specific peptidase 32///ubiquitin specific peptidase 6",TRUE
+"1555063_at",0.902212740485572,0.60070359400661,0.530997230548307,-5.80327740592653,0.131020003430726,"USP32///USP6","ubiquitin specific peptidase 32///ubiquitin specific peptidase 6",TRUE
+"1559324_at",0.641326159307468,0.11184352865106,1.65587318696278,-4.68575084379935,1.05660551111185,"USP32P2","ubiquitin specific peptidase 32 pseudogene 2",TRUE
+"213510_x_at",0.875173069858743,0.522078552291043,0.650467840676891,-5.73567783211281,0.401738528960287,"USP32P2","ubiquitin specific peptidase 32 pseudogene 2",TRUE
+"214843_s_at",0.819479221404744,0.376597341673071,0.902309595396174,-5.55072925936182,0.287084073250135,"USP33","ubiquitin specific peptidase 33",TRUE
+"212513_s_at",0.92654417487241,0.680567243948349,0.417171661176347,-5.85527246791186,0.133787220592128,"USP33","ubiquitin specific peptidase 33",TRUE
+"217441_at",0.977874971442423,0.892922218451632,-0.136162737078279,-5.93065722118028,-0.0529476581745287,"USP33","ubiquitin specific peptidase 33",TRUE
+"212065_s_at",0.348854934125219,0.0091346441916983,2.85651305555037,-2.59544529929658,0.718118241453709,"USP34","ubiquitin specific peptidase 34",TRUE
+"233595_at",0.620912785033482,0.0906639587566241,1.76897232305797,-4.52064283147761,0.805690787586231,"USP34","ubiquitin specific peptidase 34",TRUE
+"212066_s_at",0.686747966354964,0.155245483054835,1.4713958102685,-4.93685330268555,0.371754642535967,"USP34","ubiquitin specific peptidase 34",TRUE
+"242647_at",0.756313947022433,0.251464703746611,1.17756444792636,-5.28596010705258,0.379778588998033,"USP34","ubiquitin specific peptidase 34",TRUE
+"215013_s_at",0.76159330462167,0.2607046972664,1.15422846166177,-5.31082771390071,0.840873376654716,"USP34","ubiquitin specific peptidase 34",TRUE
+"207365_x_at",0.845983519082925,0.443903450918519,0.779549989285403,-5.64795291212777,0.26732168199665,"USP34","ubiquitin specific peptidase 34",TRUE
+"229198_at",0.97545133752419,0.882891482810054,0.149012832841748,-5.92887411308117,0.04982366065755,"USP35","ubiquitin specific peptidase 35",TRUE
+"224979_s_at",0.509163975230892,0.0338209898866315,2.26231261269802,-3.71374658796797,0.811594457753677,"USP36","ubiquitin specific peptidase 36",TRUE
+"224978_s_at",0.68747436517451,0.156189758790991,-1.4678819546352,-4.94140681539427,-0.474988680600369,"USP36","ubiquitin specific peptidase 36",TRUE
+"1554836_at",0.843475287501313,0.438372445917675,0.789176832904862,-5.64080954606488,0.523114245114524,"USP36","ubiquitin specific peptidase 36",TRUE
+"220370_s_at",0.850493643619556,0.453175976936836,0.763573595263374,-5.65962522310808,0.301629177465777,"USP36","ubiquitin specific peptidase 36",TRUE
+"227093_at",0.969946179106301,0.857701923597617,0.181401168489832,-5.92366869202179,0.0623237724785213,"USP36","ubiquitin specific peptidase 36",TRUE
+"226730_s_at",0.616413638398853,0.0873520415238101,-1.78866328102279,-4.49107325870037,-0.582133760406828,"USP37","ubiquitin specific peptidase 37",TRUE
+"226729_at",0.720018659171833,0.195998614723426,-1.33324343221127,-5.10911866038219,-0.403092948719554,"USP37","ubiquitin specific peptidase 37",TRUE
+"232033_at",0.916057757219214,0.645988429398573,-0.465681764499097,-5.83460763552836,-0.16781185214011,"USP37","ubiquitin specific peptidase 37",TRUE
+"223289_s_at",0.62110896023334,0.0914413826864636,-1.76443997460313,-4.52741502796523,-0.535572396993434,"USP38","ubiquitin specific peptidase 38",TRUE
+"223288_at",0.673322568613087,0.138961516521107,-1.53491663086596,-4.8530333018579,-0.506800636507867,"USP38","ubiquitin specific peptidase 38",TRUE
+"241375_at",0.887462893068143,0.551997328433088,-0.603970973615377,-5.76355704807467,-0.19686627355008,"USP38","ubiquitin specific peptidase 38",TRUE
+"217829_s_at",0.603702127972549,0.0778417495381121,-1.84902694099467,-4.39895347779991,-0.592990815740251,"USP39","ubiquitin specific peptidase 39",TRUE
+"202682_s_at",0.972438691973544,0.867177284948114,-0.169196493872051,-5.92574971495824,-0.0687507681490462,"USP4","ubiquitin specific peptidase 4",TRUE
+"211800_s_at",0.98539961718117,0.928353600728969,0.0909448563646264,-5.93565580050179,0.0378561775994868,"USP4","ubiquitin specific peptidase 4",TRUE
+"225085_at",0.908667507590078,0.620097016516112,-0.502755429655965,-5.8173161838673,-0.209744158701731,"USP40","ubiquitin specific peptidase 40",TRUE
+"225089_at",0.983776659131408,0.920494674491899,-0.100954359459826,-5.93472065804416,-0.0381001316696263,"USP40","ubiquitin specific peptidase 40",TRUE
+"228982_s_at",0.820293495506061,0.379300658738495,0.897118129469685,-5.5551079998218,0.33497619739607,"USP42","ubiquitin specific peptidase 42",TRUE
+"226176_s_at",0.920780424288498,0.663082940114054,0.441565608922681,-5.84515945555156,0.16060391360099,"USP42","ubiquitin specific peptidase 42",TRUE
+"226669_at",0.932806828930344,0.703183653611213,0.385992530749158,-5.86737522522024,0.112472696384721,"USP42","ubiquitin specific peptidase 42",TRUE
+"226172_at",0.932830928398943,0.7033385935331,0.385780302499236,-5.86745443352236,0.122089614179833,"USP42","ubiquitin specific peptidase 42",TRUE
+"226174_at",0.997763494670794,0.989060564409561,-0.0138665356249622,-5.93958982828969,-0.00674954944039907,"USP42","ubiquitin specific peptidase 42",TRUE
+"237439_at",0.687545925823023,0.156522044792547,1.46664954269585,-4.94300177777254,0.515202830658358,"USP43","ubiquitin specific peptidase 43",TRUE
+"224048_at",0.689130495692328,0.158093531000802,1.46084962907231,-4.95049332861879,1.56113074590073,"USP44","ubiquitin specific peptidase 44",TRUE
+"234132_at",0.671508325576995,0.137679164695347,1.54017369683743,-4.84596978001842,0.513805617275568,"USP45","ubiquitin specific peptidase 45",TRUE
+"224441_s_at",0.870861660648593,0.510755372736881,0.668442854938389,-5.72436821174525,0.251182647349526,"USP45","ubiquitin specific peptidase 45",TRUE
+"238057_at",0.900376038169601,0.595278625414627,0.538975255022022,-5.79917632945208,0.269545748197387,"USP45","ubiquitin specific peptidase 45",TRUE
+"203870_at",0.6708432030569,0.136628270495734,-1.544512047878,-4.84012626080111,-0.556007605725982,"USP46","ubiquitin specific peptidase 46",TRUE
+"219943_s_at",0.680972290639028,0.148942072467002,1.49530777336271,-4.90563330586084,1.02572175869311,"USP46","ubiquitin specific peptidase 46",TRUE
+"203869_at",0.716280952967285,0.192071124950368,-1.34550526810821,-5.09439966686598,-0.465349533136294,"USP46","ubiquitin specific peptidase 46",TRUE
+"222941_at",0.986409038173422,0.935903328424422,-0.081338133121523,-5.93646163739908,-0.0333498685842342,"USP46","ubiquitin specific peptidase 46",TRUE
+"235667_at",0.737037362362438,0.222418138343508,-1.25538453540641,-5.19991258960253,-0.444154377030683,"USP46-AS1","USP46 antisense RNA 1",TRUE
+"221518_s_at",0.720952283360079,0.197032687973847,1.33004705719698,-5.11293695440965,0.518846999985982,"USP47","ubiquitin specific peptidase 47",TRUE
+"223701_s_at",0.790240875783718,0.31970261649705,1.01792075882406,-5.44722791200298,0.40129379892233,"USP47","ubiquitin specific peptidase 47",TRUE
+"223119_s_at",0.939682421466574,0.729523543557232,0.350162563899808,-5.88013862899715,0.244201838713693,"USP47","ubiquitin specific peptidase 47",TRUE
+"223118_s_at",0.943294768503521,0.745005661279278,0.329321334530323,-5.88699785754474,0.173227102580219,"USP47","ubiquitin specific peptidase 47",TRUE
+"223117_s_at",0.958813918694598,0.813697475786461,0.238484131159748,-5.91201982481402,0.0877748051101062,"USP47","ubiquitin specific peptidase 47",TRUE
+"220078_at",0.75710709622615,0.252840759461592,1.17404920989907,-5.28973393280801,0.464641197715168,"USP48","ubiquitin specific peptidase 48",TRUE
+"229812_at",0.765671638296866,0.265936980544261,-1.1412845192577,-5.32443267622103,-0.562828824232449,"USP48","ubiquitin specific peptidase 48",TRUE
+"220079_s_at",0.867159108376357,0.499202145488018,0.687014050737023,-5.71237358020266,0.219822687318851,"USP48","ubiquitin specific peptidase 48",TRUE
+"225925_s_at",0.900019475989605,0.594629358306474,0.539932440549052,-5.79868029554776,0.167061942252163,"USP48","ubiquitin specific peptidase 48",TRUE
+"232621_at",0.996437521591612,0.98245160353118,0.0222450497424617,-5.93944246421372,0.0190623097426403,"USP48","ubiquitin specific peptidase 48",TRUE
+"244133_at",0.851130153581661,0.454284787230218,0.761676429580614,-5.66099612044688,0.272851243925295,"USP49","ubiquitin specific peptidase 49",TRUE
+"242120_at",0.943294768503521,0.745165651228649,0.329106755010521,-5.88706631462327,0.116102564577827,"USP49","ubiquitin specific peptidase 49",TRUE
+"1564029_at",0.964139757291246,0.835305645416169,-0.210364598227448,-5.91815230380943,-0.0946083901807047,"USP49","ubiquitin specific peptidase 49",TRUE
+"229351_at",0.97304633500821,0.869119847134193,-0.166697697754144,-5.92615796709163,-0.057759145900091,"USP49","ubiquitin specific peptidase 49",TRUE
+"243392_at",0.980832655742,0.910175596737967,0.114113461673056,-5.93334299169481,0.0513954953458278,"USP49","ubiquitin specific peptidase 49",TRUE
+"222964_at",0.986285942607238,0.932892890239425,0.085167802136773,-5.93615115922521,0.0668762481231049,"USP49","ubiquitin specific peptidase 49",TRUE
+"220667_at",0.994145854504594,0.973304220441979,-0.0338444734684427,-5.93912559047344,-0.0179973704501011,"USP49","ubiquitin specific peptidase 49",TRUE
+"206031_s_at",0.871451481476429,0.512444075035419,0.66574818069947,-5.72608248873433,0.267067631022757,"USP5","ubiquitin specific peptidase 5",TRUE
+"229278_at",0.822873158500962,0.388733256715525,-0.879191516324893,-5.57004827898071,-0.660544862905612,"USP51","ubiquitin specific peptidase 51",TRUE
+"237247_at",0.968066640321622,0.850128310775341,-0.191176535456403,-5.92189773187489,-0.135377451724323,"USP51","ubiquitin specific peptidase 51",TRUE
+"237465_at",0.792365216719119,0.32354759962658,1.00968203786299,-5.45497910671238,0.611413990989964,"USP53","ubiquitin specific peptidase 53",TRUE
+"230083_at",0.822862741321714,0.38867331861809,-0.879304526650387,-5.56995497034722,-0.343802228481486,"USP53","ubiquitin specific peptidase 53",TRUE
+"216775_at",0.829519289742569,0.400959042677841,0.856372398813944,-5.58866080934468,0.837219525853938,"USP53","ubiquitin specific peptidase 53",TRUE
+"231817_at",0.849935057946582,0.452261053851881,-0.765141131314582,-5.6584900853022,-0.320222645312912,"USP53","ubiquitin specific peptidase 53",TRUE
+"227334_at",0.86731034667719,0.499605658319124,0.686361359253303,-5.7128004636656,0.190011745793818,"USP54","ubiquitin specific peptidase 54",TRUE
+"204761_at",0.630603891142543,0.101617103481976,1.707968990845,-4.61071336368612,0.604932301217731,"USP6NL","USP6 N-terminal like",TRUE
+"238164_at",0.890816525789205,0.559738778861849,0.592159359309072,-5.77032163594008,0.240372788629447,"USP6NL","USP6 N-terminal like",TRUE
+"239865_at",0.921312278448293,0.664802490803384,0.439154642634533,-5.84618409664359,0.32154875255123,"USP6NL","USP6 N-terminal like",TRUE
+"230967_s_at",0.579111490485788,0.062097099006076,1.96481996530183,-4.21624088312452,1.48456506691955,"USP7","ubiquitin specific peptidase 7",TRUE
+"201498_at",0.618322986548619,0.0892398113736654,-1.77736240678209,-4.50807284458062,-0.663886416769724,"USP7","ubiquitin specific peptidase 7",TRUE
+"201499_s_at",0.73223722457785,0.216447299767074,-1.27232910095792,-5.18054889600402,-0.399050276219695,"USP7","ubiquitin specific peptidase 7",TRUE
+"222032_s_at",0.94549590267404,0.75350878769485,0.317938433598338,-5.89056835402136,0.154344749253961,"USP7","ubiquitin specific peptidase 7",TRUE
+"202745_at",0.493519901382617,0.0298168046227642,-2.3219115588314,-3.60788785461208,-0.850875046067131,"USP8","ubiquitin specific peptidase 8",TRUE
+"229501_s_at",0.739508010556618,0.227603046853909,-1.240950512087,-5.21623160340202,-0.467455753681955,"USP8","ubiquitin specific peptidase 8",TRUE
+"201100_s_at",0.641547541078628,0.111967641809288,-1.65526610144775,-4.68661486714233,-0.594727166448202,"USP9X","ubiquitin specific peptidase 9, X-linked",TRUE
+"201099_at",0.773351178590004,0.284672442986784,-1.09641275143939,-5.37054508925283,-0.394013771977404,"USP9X","ubiquitin specific peptidase 9, X-linked",TRUE
+"229573_at",0.79071406924554,0.32040731969154,-1.01640562027444,-5.44865766928805,-0.489719174100641,"USP9X","ubiquitin specific peptidase 9, X-linked",TRUE
+"230543_at",0.994471114396429,0.974506605884499,-0.0323195409214741,-5.93917473043544,-0.0245490239058501,"USP9X","ubiquitin specific peptidase 9, X-linked",TRUE
+"206624_at",0.803489780415187,0.341586266874255,0.97191121589608,-5.48978208391835,0.738785512107516,"USP9Y","ubiquitin specific peptidase 9, Y-linked",TRUE
+"228492_at",0.899423459651693,0.59020603356897,0.546467212885876,-5.79527098184433,0.32651996916778,"USP9Y","ubiquitin specific peptidase 9, Y-linked",TRUE
+"1562238_at",0.867972140419125,0.501622015417714,0.683104324848064,-5.71492488468277,0.627652133951982,"USPL1","ubiquitin specific peptidase like 1",TRUE
+"204190_at",0.963212667056343,0.83258801827343,-0.213891151875357,-5.91742515651765,-0.0721697037316886,"USPL1","ubiquitin specific peptidase like 1",TRUE
+"205139_s_at",0.72050514215489,0.196505228209923,-1.33167581809873,-5.11099224843666,-0.805956154566434,"UST","uronyl 2-sulfotransferase",TRUE
+"205138_s_at",0.723655063748891,0.200505635356629,-1.3194070969402,-5.12559151450084,-1.02063434541151,"UST","uronyl 2-sulfotransferase",TRUE
+"1557742_a_at",0.909253608893833,0.623231359423842,-0.49823025678,-5.81949606289478,-0.390736188256562,"UST-AS1","UST antisense RNA 1",TRUE
+"1557741_at",0.977128286470696,0.890844523181712,-0.138822414275555,-5.93030132130453,-0.147120470265346,"UST-AS1","UST antisense RNA 1",TRUE
+"208275_x_at",0.0550194051692779,9.72381240351815e-05,-4.74055171446158,1.39656520261379,-1.52063688092589,"UTF1","undifferentiated embryonic cell transcription factor 1",TRUE
+"233760_at",0.835083899263907,0.413874066003752,-0.832746824512414,-5.60745033180109,-0.58839890721163,"UTP11","UTP11, small subunit processome component homolog (S. cerevisiae)",TRUE
+"218235_s_at",0.89961817630669,0.590475650738901,-0.546068208960397,-5.7954802921925,-0.145488460446352,"UTP11","UTP11, small subunit processome component homolog (S. cerevisiae)",TRUE
+"221514_at",0.843753336849204,0.439398637879035,-0.787385120922331,-5.6421452975817,-0.292965833162087,"UTP14A","UTP14A small subunit processome component",TRUE
+"221098_x_at",0.895213601869362,0.57308808390274,-0.571988145946133,-5.78157497889929,-0.269660367727074,"UTP14A","UTP14A small subunit processome component",TRUE
+"228050_at",0.804656080879986,0.343570274189722,-0.96784139685047,-5.49345997274582,-0.305845546308198,"UTP15","UTP15, small subunit processome component",TRUE
+"228043_at",0.919375181609246,0.657342745303496,-0.449633273836082,-5.84169074176586,-0.151404058616178,"UTP15","UTP15, small subunit processome component",TRUE
+"222038_s_at",0.694293001478294,0.163608066411456,1.44085889555917,-4.9761296892271,0.603146267876564,"UTP18","UTP18, small subunit processome component",TRUE
+"203721_s_at",0.819018525257656,0.374201722435554,-0.906930730761621,-5.54681192506807,-0.302454934550163,"UTP18","UTP18, small subunit processome component",TRUE
+"209725_at",0.998347572104896,0.99206533686806,0.0100576068745922,-5.93963421177612,0.00495997270072834,"UTP20","UTP20, small subunit processome component",TRUE
+"227836_at",0.857148066512338,0.471815172473349,-0.732043113058653,-5.68198987063804,-0.309597891763822,"UTP23","UTP23, small subunit processome component",TRUE
+"238562_at",0.940534311798932,0.73369417343459,-0.344533090748646,-5.88203240382981,-0.163035082206152,"UTP23","UTP23, small subunit processome component",TRUE
+"227402_s_at",0.968035667633768,0.849259627400877,0.192298958281806,-5.92168846022373,0.0993200277495223,"UTP23","UTP23, small subunit processome component",TRUE
+"238561_s_at",0.990810941805126,0.953618991085444,-0.0588247919638691,-5.93799820938691,-0.0239202547485124,"UTP23","UTP23, small subunit processome component",TRUE
+"209486_at",0.702809964629668,0.174472260656598,-1.40301031727331,-5.02387472966504,-0.433322761547949,"UTP3","UTP3, small subunit processome component homolog (S. cerevisiae)",TRUE
+"230656_s_at",0.880842449447422,0.536587858239563,0.627744893575727,-5.74955093573461,0.210341904123855,"UTP4","UTP4, small subunit processome component",TRUE
+"224903_at",0.987901191080947,0.942169541979422,-0.0733706216413588,-5.93706183917169,-0.0256201002493235,"UTP4","UTP4, small subunit processome component",TRUE
+"228179_at",0.947326616179611,0.760525254381317,-0.308577917243979,-5.89341129047638,-0.156027659651762,"UTP4///HAS3","UTP4, small subunit processome component///hyaluronan synthase 3",TRUE
+"218715_at",0.718706241731185,0.194607320091612,1.33756490284442,-5.10394411533248,0.501629497166929,"UTP6","UTP6, small subunit processome component",TRUE
+"241025_at",0.94677940770163,0.758739579841877,0.310957445628944,-5.89269656759442,0.205847212579583,"UTP6","UTP6, small subunit processome component",TRUE
+"213023_at",0.948429371744093,0.764998242639335,0.302625306286542,-5.89517540642604,0.146811513287211,"UTRN","utrophin",TRUE
+"213022_s_at",0.962741248200658,0.83038484466438,0.216752155807135,-5.9168263978454,0.11407575234559,"UTRN","utrophin",TRUE
+"225093_at",0.980264692225439,0.907997817042465,0.11689317110382,-5.93303043422511,0.0630392482101563,"UTRN","utrophin",TRUE
+"220784_s_at",0.646692716816097,0.117705704867388,1.62779858932437,-4.72545342332989,1.591998373528,"UTS2","urotensin 2",TRUE
+"220785_at",0.752923567429559,0.246269431662097,1.19096702542399,-5.27148128536323,0.607709773890608,"UTS2","urotensin 2",TRUE
+"243175_at",0.986342822130003,0.935489494760498,0.0818645081750674,-5.93641980927667,0.0456599685287493,"UTS2B","urotensin 2B",TRUE
+"1553262_a_at",0.819018525257656,0.37320740682785,0.908854500622056,-5.54517569871821,0.2444642693389,"UTS2R","urotensin 2 receptor",TRUE
+"210322_x_at",0.754513748034606,0.247875013071211,-1.18680262093116,-5.27599540013587,-0.655544117941703,"UTY","ubiquitously transcribed tetratricopeptide repeat containing, Y-linked",TRUE
+"211149_at",0.864656349564184,0.491986999639789,0.698735824120778,-5.7046411774989,0.671058410459479,"UTY","ubiquitously transcribed tetratricopeptide repeat containing, Y-linked",TRUE
+"208067_x_at",0.93500920855517,0.711140596667681,-0.375116594770576,-5.87137905862134,-0.126878299648115,"UTY","ubiquitously transcribed tetratricopeptide repeat containing, Y-linked",TRUE
+"203241_at",0.994145854504594,0.97313581933091,-0.034058055669156,-5.93911852710053,-0.0139009842658062,"UVRAG","UV radiation resistance associated",TRUE
+"233893_s_at",0.662575055303091,0.130310959873571,-1.57118822284806,-4.80391017149283,-0.6652876525464,"UVSSA","UV stimulated scaffold protein A",TRUE
+"1555107_a_at",0.791707425459848,0.322475068404039,-1.01197327185354,-5.45282918023552,-0.425930224900641,"UVSSA","UV stimulated scaffold protein A",TRUE
+"241201_at",0.7995040428866,0.33501927589604,0.985498792241406,-5.47740113411893,0.640859325198439,"UVSSA","UV stimulated scaffold protein A",TRUE
+"234761_at",0.986889306520757,0.93950992172696,0.076751712628435,-5.93681468415005,0.0215651993387143,"UVSSA","UV stimulated scaffold protein A",TRUE
+"225583_at",0.880842449447422,0.536586130054786,0.627747580125723,-5.74954932355406,0.275694135403803,"UXS1","UDP-glucuronate decarboxylase 1",TRUE
+"219675_s_at",0.997056683282451,0.98505962908675,0.018938562968602,-5.93950878773163,0.00663706853773149,"UXS1","UDP-glucuronate decarboxylase 1",TRUE
+"218495_at",0.93032716386748,0.692034487664424,-0.401312236793026,-5.86154420943082,-0.115008009477428,"UXT","ubiquitously expressed prefoldin like chaperone",TRUE
+"218169_at",0.843753336849204,0.439382116813925,-0.787413946034223,-5.64212383060278,-0.430792258400212,"VAC14","Vac14, PIKFYVE complex component",TRUE
+"216407_at",0.937462538530338,0.722523752282255,-0.359636905476327,-5.87688296197344,-0.162740788249193,"VAC14","Vac14, PIKFYVE complex component",TRUE
+"216501_at",0.951810226174863,0.778863234258487,-0.284243548141253,-5.9004079459988,-0.156053997483719,"VAC14","Vac14, PIKFYVE complex component",TRUE
+"1564158_a_at",0.580630437263151,0.0630644561876435,1.95699951308548,-4.22882187302735,1.33040567888078,"VAC14-AS1","VAC14 antisense RNA 1",TRUE
+"207100_s_at",0.855405088766616,0.468255738231072,-0.73800631939805,-5.67782870108459,-0.675023249709228,"VAMP1","vesicle associated membrane protein 1",TRUE
+"213326_at",0.975265330414469,0.880223326793892,-0.152435171956352,-5.92837218055797,-0.0827990014138607,"VAMP1","vesicle associated membrane protein 1",TRUE
+"207101_at",0.975398143273847,0.881756652035846,0.150468210665496,-5.92866205188684,0.0808977047943538,"VAMP1","vesicle associated membrane protein 1",TRUE
+"201557_at",0.913627134030439,0.637856355410471,-0.477252382553878,-5.82934998911851,-0.188338316977037,"VAMP2","vesicle associated membrane protein 2",TRUE
+"214792_x_at",0.94943075115007,0.771608129550401,0.293849249859947,-5.89771414411648,0.116762248206332,"VAMP2","vesicle associated membrane protein 2",TRUE
+"201556_s_at",0.996118448346386,0.980593246669582,-0.0246012502376791,-5.93938870396363,-0.0126412373222982,"VAMP2","vesicle associated membrane protein 2",TRUE
+"201336_at",0.539609110035715,0.0444596652622134,2.1306370505748,-3.94170513555229,0.754843272060757,"VAMP3","vesicle associated membrane protein 3",TRUE
+"211749_s_at",0.622434989367596,0.0928192158736928,1.75648792906647,-4.53926603476991,0.643074370630563,"VAMP3","vesicle associated membrane protein 3",TRUE
+"201337_s_at",0.643082025527735,0.113529394694867,1.64767501161511,-4.697398306738,0.715548075483239,"VAMP3","vesicle associated membrane protein 3",TRUE
+"213480_at",0.720018659171833,0.195908867826181,-1.33352146676052,-5.10878616432673,-0.493959258192874,"VAMP4","vesicle associated membrane protein 4",TRUE
+"211760_s_at",0.975634784689022,0.883808235040925,0.147837373293688,-5.92904388636977,0.0696193553641073,"VAMP4","vesicle associated membrane protein 4",TRUE
+"207350_s_at",0.996261754016157,0.981486889639715,-0.0234681882322181,-5.93941523143673,-0.00780794369335958,"VAMP4","vesicle associated membrane protein 4",TRUE
+"214115_at",0.595019326272843,0.0718922067885714,1.89013743111919,-4.3349711857273,0.724828239692637,"VAMP5","vesicle associated membrane protein 5",TRUE
+"204929_s_at",0.820291269575398,0.378949390738046,-0.897791327034173,-5.55454150991824,-0.574138476861432,"VAMP5","vesicle associated membrane protein 5",TRUE
+"202829_s_at",0.726636642789909,0.205887492319168,-1.30319926094336,-5.14470316350199,-0.471887522876607,"VAMP7","vesicle associated membrane protein 7",TRUE
+"202546_at",0.597654932724127,0.0743469939266854,-1.87282808150389,-4.36203162526197,-0.964316229248945,"VAMP8","vesicle associated membrane protein 8",TRUE
+"229134_at",0.859483694145165,0.476995389389387,0.723411703088573,-5.68795613369933,0.508871310268256,"VANGL1","VANGL planar cell polarity protein 1",TRUE
+"219330_at",0.92294923958829,0.669908378108117,0.432011217057495,-5.84918765914958,0.244738040990971,"VANGL1","VANGL planar cell polarity protein 1",TRUE
+"229492_at",0.933548873991014,0.70579405726421,-0.382419341806577,-5.86870309328527,-0.240726290669384,"VANGL1","VANGL planar cell polarity protein 1",TRUE
+"229997_at",0.942502815705589,0.742018877087234,0.333330137255065,-5.8857108163509,0.220151873045085,"VANGL1","VANGL planar cell polarity protein 1",TRUE
+"226029_at",0.283622246282531,0.00478903348191733,3.13476391626646,-2.03324577296603,2.90422865286743,"VANGL2","VANGL planar cell polarity protein 2",TRUE
+"225198_at",0.455844917627971,0.0222273900392532,2.4585443017482,-3.35935703612965,0.971858806804075,"VAPA","VAMP associated protein A",TRUE
+"208780_x_at",0.619119851132342,0.0894280170316108,1.77624705434614,-4.509746369829,0.49284557968023,"VAPA","VAMP associated protein A",TRUE
+"242780_at",0.633411263775153,0.104662418405323,1.69200766354267,-4.63389014716442,0.647634868348248,"VAPA","VAMP associated protein A",TRUE
+"228480_at",0.67842163564685,0.14583538259634,1.50739777547993,-4.88969447730878,0.722867647901485,"VAPA","VAMP associated protein A",TRUE
+"239750_x_at",0.830635993561085,0.404155787221398,0.850479864332165,-5.59339306145066,0.613313585525809,"VAPA","VAMP associated protein A",TRUE
+"202550_s_at",0.718958043234793,0.19498893387267,-1.33637717702444,-5.10536770442771,-0.577527965161625,"VAPB","VAMP associated protein B and C",TRUE
+"202549_at",0.940044918888428,0.731522706555951,0.347462686283592,-5.88105066328389,0.303968764885139,"VAPB","VAMP associated protein B and C",TRUE
+"225923_at",0.993225426079816,0.968411382460471,0.0400507321786289,-5.93890223190525,0.0173728454539521,"VAPB","VAMP associated protein B and C",TRUE
+"201796_s_at",0.860567464069796,0.480091976022989,0.718278287681006,-5.69147258500225,0.282553403548174,"VARS","valyl-tRNA synthetase",TRUE
+"201797_s_at",0.936456142259101,0.716494504479156,0.367824543245272,-5.87400031224283,0.142348187894127,"VARS","valyl-tRNA synthetase",TRUE
+"226200_at",0.961212424803935,0.823970305178895,0.225092608434712,-5.91503569455459,0.0824193123573433,"VARS2","valyl-tRNA synthetase 2, mitochondrial",TRUE
+"1556423_at",0.482805047227557,0.0275598454942333,-2.35882778511146,-3.54152262640626,-2.22446746372524,"VASH1","vasohibin 1",TRUE
+"230546_at",0.699391325858549,0.170899578100446,1.41524307753421,-5.00855754863832,0.459870801447414,"VASH1","vasohibin 1",TRUE
+"203940_s_at",0.971494658787945,0.864261549217113,-0.172949198450563,-5.92512522076575,-0.111622161634345,"VASH1","vasohibin 1",TRUE
+"242566_at",0.991880277547267,0.962708928918168,-0.0472859899419236,-5.93859448339258,-0.0323547768728791,"VASH1","vasohibin 1",TRUE
+"239810_at",0.995710500788917,0.979444739615623,0.0260575065467745,-5.93935277338902,0.0125558652569135,"VASH1","vasohibin 1",TRUE
+"235343_at",0.676475496596199,0.143479117826972,-1.51670867529977,-4.87734949926201,-1.50522097333004,"VASH2","vasohibin 2",TRUE
+"219740_at",0.73759219552868,0.224201160753652,-1.25039214959965,-5.20557528418422,-0.77437459663355,"VASH2","vasohibin 2",TRUE
+"1555092_at",0.968271298107834,0.850960537605302,0.190101453683342,-5.92209703233931,0.0508482396244192,"VASH2","vasohibin 2",TRUE
+"225867_at",0.961551569993665,0.82578242284504,0.222734788124516,-5.91554874279153,0.112296490283351,"VASN","vasorin",TRUE
+"202205_at",0.969882914559333,0.857160422139315,0.182099480274951,-5.92354525403539,0.0705307936214581,"VASP","vasodilator-stimulated phosphoprotein",TRUE
+"208626_s_at",0.680708651141727,0.148683514101941,1.49630608296482,-4.90432108641063,0.875680213529336,"VAT1","vesicle amine transport 1",TRUE
+"226415_at",0.87548954903345,0.522879279385909,-0.649204913386695,-5.73646132721347,-0.412501874304418,"VAT1L","vesicle amine transport 1 like",TRUE
+"206219_s_at",0.860085676417428,0.479239931958892,0.719688844844495,-5.69050870941292,0.765234892645737,"VAV1","vav guanine nucleotide exchange factor 1",TRUE
+"205536_at",0.784789297644843,0.309216593095749,1.04074799542517,-5.42545445167217,0.340211921560952,"VAV2","vav guanine nucleotide exchange factor 2",TRUE
+"205537_s_at",0.898609426925686,0.588185762509088,0.54945985573551,-5.7936963604476,0.315556392824506,"VAV2","vav guanine nucleotide exchange factor 2",TRUE
+"226063_at",0.97689149311934,0.889800155135454,0.140159705745119,-5.93011977786581,0.0513200149503401,"VAV2","vav guanine nucleotide exchange factor 2",TRUE
+"224221_s_at",0.588653540532996,0.0673504712477667,-1.92357456420341,-4.28220573369502,-1.83771161577417,"VAV3","vav guanine nucleotide exchange factor 3",TRUE
+"218807_at",0.593339168375633,0.0703214084572258,-1.90148687605576,-4.31713346730128,-1.76597248748873,"VAV3","vav guanine nucleotide exchange factor 3",TRUE
+"218806_s_at",0.748924337581408,0.242037914858726,-1.20204069210264,-5.25941076090021,-1.41821920634484,"VAV3","vav guanine nucleotide exchange factor 3",TRUE
+"220443_s_at",0.859483694145165,0.47693022956397,-0.723519931725013,-5.68788173949173,-0.390401818823354,"VAX2","ventral anterior homeobox 2",TRUE
+"201472_at",0.661121988136487,0.128850771021169,-1.57750616137064,-4.79526147171629,-0.459189425854387,"VBP1","VHL binding protein 1",TRUE
+"203868_s_at",0.980264692225439,0.907644175746319,0.117344645919969,-5.93297896012642,0.0480305214376946,"VCAM1","vascular cell adhesion molecule 1",TRUE
+"221731_x_at",0.695739345331756,0.165077896393584,1.43562245719864,-4.98279735815915,1.52247291740701,"VCAN","versican",TRUE
+"215646_s_at",0.729083413548563,0.211217549596769,1.28746845878365,-5.16306075165265,2.0654780775642,"VCAN","versican",TRUE
+"211571_s_at",0.783904511800646,0.306937865361285,1.04578051619018,-5.42059573233367,1.56393298775431,"VCAN","versican",TRUE
+"204619_s_at",0.805804400675445,0.346035327360929,0.962807086814149,-5.49798996689683,1.24075158173769,"VCAN","versican",TRUE
+"204620_s_at",0.813442508625161,0.363621010709629,0.927578912847407,-5.5290830947783,0.908299957980288,"VCAN","versican",TRUE
+"200931_s_at",0.766390367856479,0.266996555663272,1.13868616429948,-5.32714744046026,0.589872214469757,"VCL","vinculin",TRUE
+"200930_s_at",0.871451481476429,0.512585372738233,0.665522935623461,-5.72622548297128,0.441264203576329,"VCL","vinculin",TRUE
+"208649_s_at",0.94409288114477,0.750093424540716,-0.322505251967154,-5.88915080521618,-0.124770510401419,"VCP","valosin containing protein",TRUE
+"208648_at",0.970353888480813,0.858945841641702,-0.179797380227578,-5.92395039795997,-0.0806811181146294,"VCP","valosin containing protein",TRUE
+"1556227_at",0.77938352158119,0.300624695302789,-1.05986275542514,-5.40688795911074,-0.462079561828237,"VCPIP1","valosin containing protein interacting protein 1",TRUE
+"234988_at",0.77938352158119,0.300644436544189,-1.05981839421657,-5.40693139901227,-0.603216513678348,"VCPIP1","valosin containing protein interacting protein 1",TRUE
+"219810_at",0.849935057946582,0.452203136540039,0.76524042535737,-5.6584181070177,0.535372391626918,"VCPIP1","valosin containing protein interacting protein 1",TRUE
+"1556228_a_at",0.872949023638115,0.517351023556394,-0.657946050474316,-5.7310085592808,-0.225530971182558,"VCPIP1","valosin containing protein interacting protein 1",TRUE
+"218940_at",0.493378740589161,0.0297325959534242,-2.32324205266639,-3.60550640952763,-0.858730463887799,"VCPKMT","valosin containing protein lysine methyltransferase",TRUE
+"237640_at",0.791211889207316,0.321614232067406,1.01381611133873,-5.45109679314812,0.527744452331744,"VCPKMT","valosin containing protein lysine methyltransferase",TRUE
+"211403_x_at",0.83560275910851,0.414986454662344,0.830733959832653,-5.60902846966606,0.514433021592517,"VCX2","variable charge, X-linked 2",TRUE
+"207281_x_at",0.897699110987203,0.585190905703917,0.553905524575619,-5.79134179109615,0.385118182569776,"VCX2","variable charge, X-linked 2",TRUE
+"206922_at",0.873540013139054,0.518906143604705,0.65548194898776,-5.73255276090769,0.364191077667533,"VCY1B///VCY","variable charge, Y-linked 1B///variable charge, Y-linked",TRUE
+"212038_s_at",0.821896104057596,0.384965792796907,-0.886317077166588,-5.56414319951994,-0.221653676328057,"VDAC1","voltage dependent anion channel 1",TRUE
+"217139_at",0.94370161759716,0.748076476056384,0.325205477715752,-5.88830323478814,0.0948621331988662,"VDAC1","voltage dependent anion channel 1",TRUE
+"217140_s_at",0.993892931327222,0.971388305731292,-0.0362745152633276,-5.93904260369928,-0.0136797126939214,"VDAC1","voltage dependent anion channel 1",TRUE
+"211662_s_at",0.892746695408886,0.565389089977967,-0.583591764688003,-5.77514752644515,-0.157246570920652,"VDAC2","voltage dependent anion channel 2",TRUE
+"208844_at",0.659314919342146,0.12723240446235,1.58457833900487,-4.78554807049087,0.608831598089796,"VDAC3","voltage dependent anion channel 3",TRUE
+"208846_s_at",0.729273475042162,0.211739748305783,-1.28594385817024,-5.164829863159,-0.597779660700031,"VDAC3","voltage dependent anion channel 3",TRUE
+"208845_at",0.774230543658252,0.287706701758994,-1.08934923331978,-5.37765426713016,-0.343838632689199,"VDAC3","voltage dependent anion channel 3",TRUE
+"213692_s_at",0.812302873476553,0.360479869655666,0.933785833212423,-5.52368194141525,0.379735205043174,"VDR","vitamin D (1,25- dihydroxyvitamin D3) receptor",TRUE
+"204253_s_at",0.986720888319514,0.938030024914191,-0.0786334530446088,-5.93667231097531,-0.0347400170184535,"VDR","vitamin D (1,25- dihydroxyvitamin D3) receptor",TRUE
+"204254_s_at",0.991689960875868,0.96135009471917,-0.049010442017574,-5.93851361141918,-0.0367847367497873,"VDR","vitamin D (1,25- dihydroxyvitamin D3) receptor",TRUE
+"204255_s_at",0.99886461451188,0.994910034677496,0.00645173443778696,-5.93966320682642,0.00430202873952723,"VDR","vitamin D (1,25- dihydroxyvitamin D3) receptor",TRUE
+"212171_x_at",0.933843132463653,0.706834278808885,0.380996873281849,-5.86922832238355,0.200980386069823,"VEGFA","vascular endothelial growth factor A",TRUE
+"210512_s_at",0.974871801904735,0.876720873242241,-0.156930469710224,-5.92769560688113,-0.0885859846269632,"VEGFA","vascular endothelial growth factor A",TRUE
+"211527_x_at",0.97689149311934,0.889929166668664,0.13999449505221,-5.93014230002309,0.102430665639652,"VEGFA","vascular endothelial growth factor A",TRUE
+"210513_s_at",0.983567332578112,0.91977217958388,0.101875078067067,-5.93462974464121,0.0521230576872611,"VEGFA","vascular endothelial growth factor A",TRUE
+"203683_s_at",0.955735662836499,0.797958432058955,-0.259089082452452,-5.90704110470064,-0.141217288685386,"VEGFB","vascular endothelial growth factor B",TRUE
+"209946_at",0.306787493213918,0.00615551429885895,3.02744549212385,-2.25234564379367,2.26477873037071,"VEGFC","vascular endothelial growth factor C",TRUE
+"207376_at",0.877857073443889,0.528961144499018,-0.639646809343513,-5.74234356000019,-0.346139738002456,"VENTX","VENT homeobox",TRUE
+"216722_at",0.884329174014288,0.543359017317531,0.617254155912167,-5.75579567345746,0.456679733034939,"VENTXP1","VENT homeobox pseudogene 1",TRUE
+"216726_at",0.944785393058556,0.751531363809124,0.320581678805926,-5.88975032585316,0.121030780470794,"VENTXP1","VENT homeobox pseudogene 1",TRUE
+"234940_s_at",0.42796179417767,0.0185406279877104,2.54145904731234,-3.2048288737735,1.41802490811686,"VEPH1","ventricular zone expressed PH domain containing 1",TRUE
+"229760_at",0.615821255316333,0.0863315483986222,1.79486025500186,-4.48171801533299,1.34422018207786,"VEPH1","ventricular zone expressed PH domain containing 1",TRUE
+"229759_s_at",0.695739345331756,0.165101219813644,1.43553966776404,-4.98290261646546,0.767798625494863,"VEPH1","ventricular zone expressed PH domain containing 1",TRUE
+"232122_s_at",0.995814851324975,0.979914597731803,-0.0254617403733352,-5.93936772254631,-0.0215021693910593,"VEPH1","ventricular zone expressed PH domain containing 1",TRUE
+"202172_at",0.899808883319249,0.593177171930113,-0.542075184348928,-5.79756677849855,-0.219642239808291,"VEZF1","vascular endothelial zinc finger 1",TRUE
+"202171_at",0.957390359236635,0.807022383991239,-0.247209493210012,-5.90996157649376,-0.115391767602427,"VEZF1","vascular endothelial zinc finger 1",TRUE
+"202173_s_at",0.970893641742918,0.86090476892404,-0.177272704255057,-5.92438880504554,-0.075617480031875,"VEZF1","vascular endothelial zinc finger 1",TRUE
+"223675_s_at",0.737978661762069,0.224707247572289,1.24898065861676,-5.20717277806558,0.46745662231398,"VEZT","vezatin, adherens junctions transmembrane protein",TRUE
+"207263_x_at",0.73957587762701,0.22817009221839,1.23938720451652,-5.2179893280054,0.792259728406302,"VEZT","vezatin, adherens junctions transmembrane protein",TRUE
+"223090_x_at",0.819018525257656,0.373562676072366,0.908166748270802,-5.54576102117581,0.329097769421736,"VEZT","vezatin, adherens junctions transmembrane protein",TRUE
+"223089_at",0.93423034725099,0.708880201889418,0.378201471703924,-5.87025486637312,0.152563384697117,"VEZT","vezatin, adherens junctions transmembrane protein",TRUE
+"205586_x_at",0.889452275006221,0.557317184397496,-0.595844932826296,-5.76822473852398,-0.231761590329667,"VGF","VGF nerve growth factor inducible",TRUE
+"205487_s_at",0.417065639753029,0.017033517577842,2.57987785639754,-3.13233869579408,4.39222578828984,"VGLL1","vestigial like family member 1",TRUE
+"215729_s_at",0.434309499513877,0.0197195023016816,2.51339137791258,-3.25743729137797,5.75177681565902,"VGLL1","vestigial like family member 1",TRUE
+"215730_at",0.896118635245982,0.578295631465683,0.564184362143227,-5.78582728847906,0.235191417712045,"VGLL1","vestigial like family member 1",TRUE
+"236352_at",0.957152264547499,0.805858921256451,0.248732306354298,-5.9095948205899,0.138672575436495,"VGLL2","vestigial like family member 2",TRUE
+"227399_at",0.117874145553551,0.000647903631702378,3.96611609358688,-0.273747874662771,5.75680677763487,"VGLL3","vestigial like family member 3",TRUE
+"220327_at",0.157585990977258,0.00121918379850718,3.70655240861925,-0.83130354779578,2.65249103691934,"VGLL3","vestigial like family member 3",TRUE
+"212399_s_at",0.789795896476304,0.317893316279826,-1.02182154921335,-5.44353808005492,-0.414461806145226,"VGLL4","vestigial like family member 4",TRUE
+"214004_s_at",0.895213601869362,0.573151935898369,-0.571892243774993,-5.78162757990073,-0.204266183183409,"VGLL4","vestigial like family member 4",TRUE
+"203844_at",0.806422472374043,0.347390951111608,0.960048938441687,-5.50046265961804,0.57339755666478,"VHL","von Hippel-Lindau tumor suppressor",TRUE
+"1559227_s_at",0.949313822701389,0.771118893348223,-0.294498001514131,-5.89752900878392,-0.0924056815505327,"VHL","von Hippel-Lindau tumor suppressor",TRUE
+"1554945_x_at",0.170994566769966,0.00144220897478987,-3.63722463845437,-0.979345662970265,-1.15305549688278,"VIL1","villin 1",TRUE
+"1554943_at",0.757361197594703,0.253378953606611,1.17267822834681,-5.29120309233006,0.458851502115934,"VIL1","villin 1",TRUE
+"228912_at",0.774230543658252,0.286041663437115,-1.09321861565844,-5.37376493959395,-0.79009382385728,"VIL1","villin 1",TRUE
+"205506_at",0.841813886364358,0.433881682917995,-0.797048132918927,-5.63490751368263,-0.646814523420784,"VIL1","villin 1",TRUE
+"209950_s_at",0.133209849616415,0.000830810401814312,3.86423391075743,-0.493102689703291,1.62943495509079,"VILL","villin like",TRUE
+"1555938_x_at",0.859465912277024,0.476737392492429,-0.723840279385303,-5.68766147689314,-0.557701889181172,"VIM","vimentin",TRUE
+"201426_s_at",0.869431261690674,0.506459057550483,0.675321063374014,-5.71996242815129,1.26006264849535,"VIM","vimentin",TRUE
+"223209_s_at",0.815634970791029,0.366517340601094,-0.921887431364613,-5.53400659057077,-0.363242360559147,"VIMP","VCP interacting membrane selenoprotein",TRUE
+"206577_at",0.991880277547267,0.962689581754907,0.0473105417506469,-5.93859335230265,0.0502172390859519,"VIP","vasoactive intestinal peptide",TRUE
+"218431_at",0.819018525257656,0.373711364376332,-0.907879036636183,-5.54600576133424,-0.324287914104834,"VIPAS39","VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog",TRUE
+"233140_s_at",0.894543861393896,0.5711714763273,-0.574869313705899,-5.77999071433621,-0.193464918920263,"VIPAS39","VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog",TRUE
+"205019_s_at",0.48580305784244,0.0285295609571551,-2.34263793816081,-3.57070101324905,-1.44201094578704,"VIPR1","vasoactive intestinal peptide receptor 1",TRUE
+"211598_x_at",0.835952408568777,0.415944245716406,0.829003568490035,-5.61038228545083,0.516594609189017,"VIPR2","vasoactive intestinal peptide receptor 2",TRUE
+"205946_at",0.930065981387326,0.691336288057839,0.402274831097684,-5.86117036261795,0.254556513331734,"VIPR2","vasoactive intestinal peptide receptor 2",TRUE
+"205947_s_at",0.997466539876354,0.987110552713929,-0.016338530725457,-5.93955346125849,-0.0119764121408945,"VIPR2","vasoactive intestinal peptide receptor 2",TRUE
+"227899_at",0.645740804644555,0.116816147022182,1.63198206703697,-4.719570279028,0.843264579989126,"VIT","vitrin",TRUE
+"217949_s_at",0.567292616148537,0.0573553862479294,-2.00478779794864,-4.15141444903659,-0.602162596209588,"VKORC1","vitamin K epoxide reductase complex subunit 1",TRUE
+"1553679_s_at",0.961395512423249,0.825103301782323,0.223618268273574,-5.91535713240171,0.092946506379997,"VKORC1L1","vitamin K epoxide reductase complex subunit 1 like 1",TRUE
+"224881_at",0.967098323798013,0.846107075461533,-0.196374495325194,-5.9209183285782,-0.0610701688796933,"VKORC1L1","vitamin K epoxide reductase complex subunit 1 like 1",TRUE
+"209822_s_at",0.768852835478002,0.274047522817857,-1.12158530709623,-5.34487812056573,-1.05357693232274,"VLDLR","very low density lipoprotein receptor",TRUE
+"235237_at",0.851650449893991,0.455740079798782,0.759190663997356,-5.66278746135799,0.435067757727726,"VMA21","VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)",TRUE
+"225556_at",0.938500267760216,0.726465225255784,-0.354297982383351,-5.87872813548715,-0.144617793395527,"VMA21","VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)",TRUE
+"242474_s_at",0.976371465776674,0.887006824023431,-0.143737801498448,-5.92962549321274,-0.0672546009080044,"VMA21","VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)",TRUE
+"235751_s_at",0.654038356341937,0.123178726685746,-1.60262693869126,-4.76060541718422,-1.75660039196779,"VMO1","vitelline membrane outer layer 1 homolog",TRUE
+"241894_at",0.948137447885351,0.764453528454286,0.303349605943202,-5.89496257278831,0.28987577304024,"VMO1","vitelline membrane outer layer 1 homolog",TRUE
+"1569003_at",0.958770864245184,0.812972278617716,0.239431146123632,-5.91179998862619,0.204906245882396,"VMP1","vacuole membrane protein 1",TRUE
+"221412_at",0.979588787486838,0.902230393842852,-0.124259307660052,-5.93216584019857,-0.0756452234650089,"VN1R1","vomeronasal 1 receptor 1",TRUE
+"233295_at",0.906476756086155,0.613354882243188,0.512525638833314,-5.81254407996947,0.400139800566635,"VN1R108P","vomeronasal 1 receptor 108 pseudogene",TRUE
+"224289_s_at",0.812302873476553,0.360725321286233,0.933299516609149,-5.52410632116074,0.77418630451151,"VN1R10P","vomeronasal 1 receptor 10 pseudogene",TRUE
+"1553549_at",0.641547541078628,0.111962508196747,1.65529120068706,-4.68657914990143,1.03598367779174,"VN1R2","vomeronasal 1 receptor 2",TRUE
+"224290_at",0.9116561917482,0.630679793353703,0.487518608032926,-5.82457939228663,0.423870005940687,"VN1R3","vomeronasal 1 receptor 3 (gene/pseudogene)",TRUE
+"1553560_at",0.975265330414469,0.880192135720269,0.152475190466874,-5.9283662440361,0.0962614149523846,"VN1R4","vomeronasal 1 receptor 4",TRUE
+"1553550_at",0.904722110947821,0.60912691625992,0.518678320080021,-5.8094929523885,0.313235906807279,"VN1R5","vomeronasal 1 receptor 5 (gene/pseudogene)",TRUE
+"1558549_s_at",0.061352539245217,0.000142510699298446,4.58429268891031,1.06073679847509,3.0303891239742,"VNN1","vanin 1",TRUE
+"205844_at",0.425751189365875,0.0181357883696338,2.55148356513093,-3.18596717426621,2.93296016868243,"VNN1","vanin 1",TRUE
+"205922_at",0.83030603167465,0.402590569390888,0.85336127203966,-5.59108282789466,0.364047017609279,"VNN2","vanin 2",TRUE
+"1553514_a_at",0.62524538993269,0.0965358069570378,1.73553169602543,-4.57030783915458,1.03160346157977,"VNN3","vanin 3",TRUE
+"1553513_at",0.942246902934074,0.739993411341312,0.336051846503481,-5.88482822088525,0.274437146917304,"VNN3","vanin 3",TRUE
+"220528_at",0.97741083362203,0.891745489045592,0.137668954651562,-5.93045651330287,0.0451889552933356,"VNN3","vanin 3",TRUE
+"208091_s_at",0.895594830714116,0.574835519250523,0.569365544398025,-5.78301036021406,0.328372915034787,"VOPP1","vesicular, overexpressed in cancer, prosurvival protein 1",TRUE
+"221349_at",0.934447550624693,0.709411045840508,-0.377476666923983,-5.8705198162906,-0.173668839796972,"VPREB1","pre-B lymphocyte 1",TRUE
+"220068_at",0.746728626876669,0.238604667741294,1.21113277413474,-5.24942767839765,0.847343890654153,"VPREB3","pre-B lymphocyte 3",TRUE
+"203292_s_at",0.757950630724418,0.254271171302074,-1.17041018307214,-5.2936302583007,-0.342596167270623,"VPS11","VPS11, CORVET/HOPS core subunit",TRUE
+"213686_at",0.64917450598886,0.119885047772648,1.61766031223514,-4.7396623805915,0.602201922292866,"VPS13A","vacuolar protein sorting 13 homolog A",TRUE
+"214852_x_at",0.670970797333726,0.136898252324503,1.54339487781948,-4.84163227086454,1.03251282752055,"VPS13A","vacuolar protein sorting 13 homolog A",TRUE
+"214785_at",0.717967110215679,0.193901368507231,1.33976691273814,-5.10130201285093,0.555006956886766,"VPS13A","vacuolar protein sorting 13 homolog A",TRUE
+"231585_at",0.836892603674282,0.418959075540352,-0.823573176886685,-5.61461373435619,-0.383486785803226,"VPS13A","vacuolar protein sorting 13 homolog A",TRUE
+"227987_at",0.936361288293618,0.716087339694203,0.368378385637469,-5.87380300602441,0.131273986197922,"VPS13A","vacuolar protein sorting 13 homolog A",TRUE
+"227988_s_at",0.994943851647199,0.97629149777544,-0.0300559848052026,-5.9392434958956,-0.00996447761391472,"VPS13A","vacuolar protein sorting 13 homolog A",TRUE
+"240767_x_at",0.831875452294783,0.407162818857485,0.844964177169412,-5.59779506099312,0.499071404978976,"VPS13A-AS1","VPS13A antisense RNA 1",TRUE
+"213243_at",0.562870988664324,0.0553975036804855,-2.02215206058997,-4.12297795480945,-0.758723649588996,"VPS13B","vacuolar protein sorting 13 homolog B",TRUE
+"220400_at",0.624988420005843,0.0963173740643664,-1.73674407609582,-4.56851950026878,-0.605652699936319,"VPS13B","vacuolar protein sorting 13 homolog B",TRUE
+"236254_at",0.75959865506602,0.25739535331361,-1.16251473112571,-5.30204753651856,-0.4525226692266,"VPS13B","vacuolar protein sorting 13 homolog B",TRUE
+"1553852_at",0.912252515563073,0.632515895523345,-0.484887006299636,-5.82581172838847,-0.40246381291297,"VPS13B","vacuolar protein sorting 13 homolog B",TRUE
+"232386_at",0.908709061737317,0.620856350980306,0.501658175652037,-5.81784652292784,0.251583614767998,"VPS13C","vacuolar protein sorting 13 homolog C",TRUE
+"235023_at",0.913221029035633,0.635878505452791,-0.480076502443212,-5.8280475524888,-0.417951142662966,"VPS13C","vacuolar protein sorting 13 homolog C",TRUE
+"218396_at",0.939976205834042,0.730456498097426,-0.348902276142004,-5.88056522976664,-0.172268524348478,"VPS13C","vacuolar protein sorting 13 homolog C",TRUE
+"220517_at",0.96820875250691,0.850500776687734,0.190695350573383,-5.92198707319701,0.137478617183482,"VPS13C","vacuolar protein sorting 13 homolog C",TRUE
+"212326_at",0.843950128127185,0.440154151679419,0.786067648804476,-5.64312567100118,0.272908324984009,"VPS13D","vacuolar protein sorting 13 homolog D",TRUE
+"1557571_at",0.91671872326659,0.647862075136145,0.463025049899145,-5.83579700203834,0.346012301743551,"VPS13D","vacuolar protein sorting 13 homolog D",TRUE
+"220221_at",0.951102506952277,0.776677178425336,0.287134953404245,-5.89960642935931,0.29437220036333,"VPS13D","vacuolar protein sorting 13 homolog D",TRUE
+"212324_s_at",0.972123107511539,0.866314152544897,-0.170307128875935,-5.92556631543582,-0.0670299536005938,"VPS13D","vacuolar protein sorting 13 homolog D",TRUE
+"212323_s_at",0.989586772349659,0.949638238234263,-0.0638804582344047,-5.93769611136723,-0.0241560481230891,"VPS13D","vacuolar protein sorting 13 homolog D",TRUE
+"203459_s_at",0.819479221404744,0.376537463866698,-0.902424862573769,-5.55063177226757,-0.410599042096889,"VPS16","VPS16, CORVET/HOPS core subunit",TRUE
+"215216_at",0.902424542997102,0.601315954075539,0.530098882697798,-5.80373547110975,0.337490251360821,"VPS16","VPS16, CORVET/HOPS core subunit",TRUE
+"1552276_a_at",0.0500178849078906,6.40375298317758e-05,-4.91175333476906,1.76277287760209,-2.54694081395505,"VPS18","VPS18, CORVET/HOPS core subunit",TRUE
+"223346_at",0.567292616148537,0.0574607500362249,-2.0038683576572,-4.15291560321288,-0.61227982880123,"VPS18","VPS18, CORVET/HOPS core subunit",TRUE
+"224608_s_at",0.650100641070116,0.120377117333221,-1.61539258668567,-4.74283124992094,-0.564037375996355,"VPS25","vacuolar protein sorting 25 homolog",TRUE
+"243316_x_at",0.824399995824329,0.391807743958117,0.873409848268354,-5.57480714338661,0.757840243501366,"VPS26A","VPS26, retromer complex component A",TRUE
+"201807_at",0.935304592897801,0.712251340281534,0.373602065148931,-5.87192765983518,0.101814819416859,"VPS26A","VPS26, retromer complex component A",TRUE
+"225483_at",0.592488489935347,0.0694633201320468,-1.90778095774309,-4.30720906469151,-0.73577011673733,"VPS26B","VPS26, retromer complex component B",TRUE
+"230306_at",0.82847108093969,0.398411958506374,-0.861089038013686,-5.5848509834403,-0.362930156748869,"VPS26B","VPS26, retromer complex component B",TRUE
+"218679_s_at",0.943512938262733,0.747622119908402,0.325814094917911,-5.88811123066875,0.183470383247322,"VPS28","VPS28, ESCRT-I subunit",TRUE
+"1554388_at",0.74413941468137,0.234871385865659,1.22113211486177,-5.23837317776889,0.67071462458775,"VPS29","VPS29, retromer complex component",TRUE
+"223026_s_at",0.902538209397152,0.601689696486743,0.529550809976671,-5.80401456118681,0.139509945366733,"VPS29","VPS29, retromer complex component",TRUE
+"227815_at",0.894538680437601,0.571083090872236,-0.575002298830453,-5.7799174037911,-0.211562023418916,"VPS33A","VPS33A, CORVET/HOPS core subunit",TRUE
+"244400_at",0.937655803006818,0.72426636766242,0.357275140984094,-5.87770256840028,0.253756714022987,"VPS33A","VPS33A, CORVET/HOPS core subunit",TRUE
+"204590_x_at",0.942450624660433,0.741361189002466,-0.334213619763244,-5.88542509909382,-0.10702475417586,"VPS33A","VPS33A, CORVET/HOPS core subunit",TRUE
+"218415_at",0.657015752622694,0.125534759144456,-1.59207780087477,-4.77521075130009,-0.595573986439936,"VPS33B","VPS33B, late endosome and lysosome associated",TRUE
+"44111_at",0.699491435574954,0.171025176237146,-1.41480958153782,-5.00910221796892,-0.462945324542078,"VPS33B","VPS33B, late endosome and lysosome associated",TRUE
+"233864_s_at",0.782930758690314,0.305431861400006,-1.04912102297902,-5.41735895489354,-0.363899619652326,"VPS35","VPS35 retromer complex component",TRUE
+"222387_s_at",0.839519981963042,0.427905912704699,-0.807600814250746,-5.62690855617306,-0.317474915256589,"VPS35","VPS35 retromer complex component",TRUE
+"222388_s_at",0.840041055449124,0.429047627765156,-0.80557761281721,-5.62844980510922,-0.240291558803971,"VPS35","VPS35 retromer complex component",TRUE
+"1561146_at",0.842167419664876,0.435363318027442,0.794445631923914,-5.63686501076441,0.622917326868584,"VPS35","VPS35 retromer complex component",TRUE
+"217727_x_at",0.875638194926234,0.523146342496863,-0.648783930764639,-5.73672217163128,-0.230901899669082,"VPS35","VPS35 retromer complex component",TRUE
+"240086_at",0.736285418018422,0.221781153165896,1.25717548846486,-5.1978764555999,0.918988432442787,"VPS36","vacuolar protein sorting 36 homolog",TRUE
+"222478_at",0.8111749793648,0.3552404884483,-0.944220183475859,-5.51452760467212,-0.525242096603094,"VPS36","vacuolar protein sorting 36 homolog",TRUE
+"225378_at",0.768055385305452,0.271232069126249,-1.12837458708309,-5.33786716049518,-0.352436764870566,"VPS37A","VPS37A, ESCRT-I subunit",TRUE
+"228024_at",0.947778780715578,0.76178187661659,-0.306904475893788,-5.89391067252808,-0.11627142301505,"VPS37A","VPS37A, ESCRT-I subunit",TRUE
+"221704_s_at",0.831875452294783,0.407688985475636,0.844001723568185,-5.59856044448366,0.423368009849126,"VPS37B","VPS37B, ESCRT-I subunit",TRUE
+"1560060_s_at",0.714791050845163,0.190237242385448,-1.3512982920066,-5.08740649977424,-0.532502539056297,"VPS37C","VPS37C, ESCRT-I subunit",TRUE
+"219053_s_at",0.740476003158683,0.229129023997169,-1.23675020744462,-5.22094994519488,-0.535421024028951,"VPS37C","VPS37C, ESCRT-I subunit",TRUE
+"1560059_at",0.906026109953261,0.61255153460306,0.513693149652384,-5.81196783715907,0.212535585443182,"VPS37C","VPS37C, ESCRT-I subunit",TRUE
+"235569_at",0.927973182663162,0.68389120113817,-0.412563534040107,-5.85711943598208,-0.402589063228707,"VPS37D","VPS37D, ESCRT-I subunit",TRUE
+"212156_at",0.885029460971826,0.545983972243671,0.613206005994748,-5.75817826230472,0.197573607535958,"VPS39","VPS39, HOPS complex subunit",TRUE
+"210849_s_at",0.886023097762234,0.548406347573236,-0.609479411912598,-5.76035822989654,-0.229631516292899,"VPS41","VPS41, HOPS complex subunit",TRUE
+"235625_at",0.985709215004606,0.931083800810618,0.087469823420387,-5.93595766229744,0.0379936909107048,"VPS41","VPS41, HOPS complex subunit",TRUE
+"203106_s_at",0.986143546287878,0.931939793443325,-0.0863805345129308,-5.93604986545175,-0.0450377030124267,"VPS41","VPS41, HOPS complex subunit",TRUE
+"209268_at",0.527546822913581,0.0401376507365401,-2.18026569947091,-3.85677500726229,-0.702210831139007,"VPS45","vacuolar protein sorting 45 homolog",TRUE
+"207967_at",0.789503009592599,0.316582096002931,-1.0246582230391,-5.44084680810374,-0.491917576733093,"VPS45","vacuolar protein sorting 45 homolog",TRUE
+"217913_at",0.603702127972549,0.0779099625080324,-1.84857171012248,-4.39965639230037,-0.538764969668438,"VPS4A","vacuolar protein sorting 4 homolog A",TRUE
+"218171_at",0.862800800218883,0.486675685902376,0.707427702666143,-5.69882692530907,0.27091611351921,"VPS4B","vacuolar protein sorting 4 homolog B",TRUE
+"1554216_at",0.757270745916058,0.253085650615648,-1.17342511155178,-5.29040290989702,-0.993943046240414,"VPS50","VPS50, EARP/GARPII complex subunit",TRUE
+"207045_at",0.863488263044072,0.488217529214467,0.704898897855508,-5.70052558409826,0.478470928195404,"VPS50","VPS50, EARP/GARPII complex subunit",TRUE
+"226031_at",0.868728651371711,0.504999771688307,0.677664762311088,-5.71845133078288,0.21180377011836,"VPS50","VPS50, EARP/GARPII complex subunit",TRUE
+"1554217_a_at",0.976371465776674,0.886157684327436,-0.144825879137552,-5.92947271858412,-0.0484758915803694,"VPS50","VPS50, EARP/GARPII complex subunit",TRUE
+"217969_at",0.945723453271709,0.754984211731945,-0.315967722795924,-5.89117388267458,-0.116203944678546,"VPS51","VPS51, GARP complex subunit",TRUE
+"214585_s_at",0.830635993561085,0.403647585079813,-0.851414628714085,-5.59264439122795,-0.226239585635147,"VPS52","VPS52, GARP complex subunit",TRUE
+"227229_at",0.724970327905974,0.203033129803045,1.31175374411912,-5.13464093651394,0.57667547134252,"VPS53","VPS53, GARP complex subunit",TRUE
+"1559109_a_at",0.806193804672023,0.346615414109287,-0.961625945558863,-5.49904965943449,-0.55079830754186,"VPS53","VPS53, GARP complex subunit",TRUE
+"235882_at",0.832792886465252,0.409839383866388,0.840076456699662,-5.60167354774335,0.308117669481674,"VPS53","VPS53, GARP complex subunit",TRUE
+"229653_at",0.845588139978284,0.443052269285567,0.781026693247361,-5.64686252489495,0.370213794921131,"VPS53","VPS53, GARP complex subunit",TRUE
+"1559108_at",0.899808883319249,0.592585508642943,0.542948936976448,-5.79711148607605,0.473508859507788,"VPS53","VPS53, GARP complex subunit",TRUE
+"1557112_a_at",0.932830928398943,0.703289740959579,-0.38584721614094,-5.86742946449848,-0.100665330700211,"VPS53","VPS53, GARP complex subunit",TRUE
+"221707_s_at",0.947778780715578,0.761664956723302,0.307060140076751,-5.89386433332303,0.13979462091329,"VPS53","VPS53, GARP complex subunit",TRUE
+"235710_at",0.952374805858222,0.782001650207295,-0.280096811088861,-5.90154339839007,-0.225959640810522,"VPS53","VPS53, GARP complex subunit",TRUE
+"219794_at",0.974670398319743,0.876087627209544,0.157743573416369,-5.92757113415547,0.157169325954562,"VPS53","VPS53, GARP complex subunit",TRUE
+"218423_x_at",0.702809964629668,0.174447045664146,1.4030959486542,-5.02376788766463,0.478314978612884,"VPS54","VPS54, GARP complex subunit",TRUE
+"233656_s_at",0.703896906014433,0.175351126018649,1.40003179653678,-5.02758767201799,0.459665194215937,"VPS54","VPS54, GARP complex subunit",TRUE
+"222627_at",0.942303845415102,0.740741290233574,0.335046587705072,-5.88515503296558,0.102018373786645,"VPS54","VPS54, GARP complex subunit",TRUE
+"202261_at",0.869940429546468,0.507755628489929,-0.673241876776125,-5.72129878798999,-0.225960694405117,"VPS72","vacuolar protein sorting 72 homolog",TRUE
+"236937_at",0.811263413918865,0.355412758181958,0.943875462821434,-5.51483152843352,0.748899598185569,"VPS8","VPS8, CORVET complex subunit",TRUE
+"1559500_at",0.904381089098038,0.607497983590023,0.521054206955184,-5.80830525023497,0.273854913459376,"VPS8","VPS8, CORVET complex subunit",TRUE
+"209553_at",0.959869386255065,0.818474712200657,0.232251195053301,-5.9134450919046,0.0933196933446663,"VPS8","VPS8, CORVET complex subunit",TRUE
+"205781_at",0.740321726337106,0.22886048105186,-1.2374878343918,-5.22012234161388,-0.432834903861338,"VPS9D1","VPS9 domain containing 1",TRUE
+"1558728_at",0.816966928109267,0.36919077465802,-0.916660502942939,-5.53850363050913,-0.812954729500717,"VPS9D1-AS1","VPS9D1 antisense RNA 1",TRUE
+"203856_at",0.9116561917482,0.630089382990476,-0.488365557798105,-5.82418139290952,-0.201361180302932,"VRK1","vaccinia related kinase 1",TRUE
+"205126_at",0.46584896273628,0.0242524917109324,2.41830330608838,-3.4333687514993,0.83262618950176,"VRK2","vaccinia related kinase 2",TRUE
+"218022_at",0.637485146909712,0.108883177769221,-1.6705246112965,-4.66482531391329,-0.553394072140314,"VRK3","vaccinia related kinase 3",TRUE
+"221998_s_at",0.697464915010884,0.168031155342241,-1.42521346472496,-4.99599237507946,-0.477140105640125,"VRK3","vaccinia related kinase 3",TRUE
+"221999_at",0.847797601020174,0.447146727268875,-0.773939039137628,-5.65207824759026,-0.213257776123001,"VRK3","vaccinia related kinase 3",TRUE
+"1566701_at",0.889452275006221,0.557354851005567,-0.595787542040023,-5.76825748723088,-0.383488280666596,"VRK3","vaccinia related kinase 3",TRUE
+"239190_at",0.940044918888428,0.731426639043035,0.347592365482766,-5.88100701641506,0.167428330831394,"VRK3","vaccinia related kinase 3",TRUE
+"1566700_at",0.979588787486838,0.901629220800355,-0.125027522405679,-5.93207263457305,-0.0744062212455505,"VRK3","vaccinia related kinase 3",TRUE
+"220536_at",0.870808709484996,0.510476267904958,0.668888703215107,-5.7240839359804,0.249324905200877,"VRTN","vertebrae development associated",TRUE
+"234370_at",0.750020866111355,0.242852375792643,1.19989805584028,-5.26175385779226,0.356825171499262,"VSIG1","V-set and immunoglobulin domain containing 1",TRUE
+"243764_at",0.902242032847473,0.600999631208138,-0.530562881242869,-5.80349897373341,-0.363909436294183,"VSIG1","V-set and immunoglobulin domain containing 1",TRUE
+"223845_at",0.895457620469779,0.574327094048256,0.570128186854893,-5.78259361600126,0.218074642738429,"VSIG10","V-set and immunoglobulin domain containing 10",TRUE
+"238654_at",0.99129909965195,0.959243922547522,-0.051683619258632,-5.9383825231669,-0.0323718139425448,"VSIG10L","V-set and immunoglobulin domain containing 10 like",TRUE
+"229369_at",0.643688366500038,0.114685556841471,1.64211176465294,-4.70527702787432,0.959656665466539,"VSIG2","V-set and immunoglobulin domain containing 2",TRUE
+"228232_s_at",0.937271400689562,0.721939639756313,-0.360429018459685,-5.87660687957644,-0.319108206087102,"VSIG2","V-set and immunoglobulin domain containing 2",TRUE
+"204787_at",0.765822707587148,0.266017464334616,1.14108688502749,-5.32463935627451,0.73915196896925,"VSIG4","V-set and immunoglobulin domain containing 4",TRUE
+"203798_s_at",0.289452415034987,0.00496925582333615,3.11903065290762,-2.06552833113446,3.59627179148687,"VSNL1","visinin like 1",TRUE
+"203797_at",0.384436276320932,0.0125086810347497,2.71812971259326,-2.86713371264857,1.90500705911707,"VSNL1","visinin like 1",TRUE
+"235818_at",0.818854105808043,0.372758963005274,-0.909723245066312,-5.5444357554956,-0.579970344189059,"VSTM1","V-set and transmembrane domain containing 1",TRUE
+"230117_at",0.807824562181406,0.34923965723,0.956299334720222,-5.50381379039256,1.08853192635307,"VSTM2A","V-set and transmembrane domain containing 2A",TRUE
+"1554530_at",0.971826767527606,0.865196885892524,-0.171745096842978,-5.92532708579976,-0.174297695300669,"VSTM2A","V-set and transmembrane domain containing 2A",TRUE
+"236308_at",0.996261754016157,0.98186877512509,0.0229840001530082,-5.93942618597897,0.0232413404534215,"VSTM2A","V-set and transmembrane domain containing 2A",TRUE
+"1560692_at",0.975123690889628,0.878785136786121,0.154280652678245,-5.92809679645062,0.0989585673680127,"VSTM2A-OT1///VSTM2A","VSTM2A overlapping transcript 1///V-set and transmembrane domain containing 2A",TRUE
+"226973_at",0.993615552413264,0.970086814780429,0.0379253822293373,-5.93898294527021,0.0478102132143317,"VSTM2L","V-set and transmembrane domain containing 2 like",TRUE
+"213381_at",0.79943091106207,0.33409047004286,0.98743529406894,-5.47562385863158,0.418007803130571,"VSTM4","V-set and transmembrane domain containing 4",TRUE
+"235471_at",0.865345395265289,0.495170129274618,0.693552478264478,-5.70807583201095,0.477165720612526,"VSTM4","V-set and transmembrane domain containing 4",TRUE
+"244057_s_at",0.9037138034254,0.605274687976009,0.524301916032636,-5.80667317244985,0.220095205661217,"VSTM4","V-set and transmembrane domain containing 4",TRUE
+"1553458_at",0.906476756086155,0.613540153276424,-0.512256485552752,-5.81267674336831,-0.357820418171596,"VSTM4","V-set and transmembrane domain containing 4",TRUE
+"244058_at",0.933922051839063,0.707298356562967,-0.380362520618312,-5.86946192705923,-0.208412495618443,"VSTM4","V-set and transmembrane domain containing 4",TRUE
+"230103_at",0.96649413975112,0.843673745135132,-0.199522566457639,-5.9203124403908,-0.102257849946349,"VSTM4","V-set and transmembrane domain containing 4",TRUE
+"222972_at",0.633326968581968,0.104577742355553,1.69244611038835,-4.6332556841962,0.735269490441373,"VSX1","visual system homeobox 1",TRUE
+"224075_s_at",0.753606468220283,0.246860390412899,1.1894318957086,-5.27314693261119,0.945396370696772,"VSX1","visual system homeobox 1",TRUE
+"221124_s_at",0.946727564264032,0.758376359850449,0.31144168394774,-5.89255045410344,0.160939093941105,"VSX1","visual system homeobox 1",TRUE
+"224074_at",0.954577684533304,0.792940231460043,-0.265682454273956,-5.90536143519525,-0.167576035967659,"VSX1","visual system homeobox 1",TRUE
+"223021_x_at",0.664342191754479,0.132321654653979,1.56258372640147,-4.81564514121767,0.48931030237541,"VTA1","vesicle trafficking 1",TRUE
+"223022_s_at",0.682744111897512,0.150679675140216,1.48863519864005,-4.91438593822244,0.427765692506508,"VTA1","vesicle trafficking 1",TRUE
+"224437_s_at",0.83364851657447,0.411146616171963,0.837696672812833,-5.60355433897444,0.240355947891926,"VTA1","vesicle trafficking 1",TRUE
+"237059_at",0.876590919968167,0.525329274507123,0.645347292618958,-5.73884546446875,0.47842848599758,"VTA1","vesicle trafficking 1",TRUE
+"219768_at",0.896115372949367,0.577520827056654,-0.565343196466857,-5.78519941580557,-0.912692921197197,"VTCN1","V-set domain containing T cell activation inhibitor 1",TRUE
+"1552536_at",0.624474658436697,0.0959983448406115,1.73851903212952,-4.5658996543867,0.76823315585464,"VTI1A","vesicle transport through interaction with t-SNAREs 1A",TRUE
+"235034_at",0.854040699678541,0.46328495458254,0.746379091946813,-5.67193208573209,0.238474720086273,"VTI1A","vesicle transport through interaction with t-SNAREs 1A",TRUE
+"242356_at",0.880045467676475,0.53523826130125,0.629844329444767,-5.74828905324507,0.22156531814087,"VTI1A","vesicle transport through interaction with t-SNAREs 1A",TRUE
+"236849_at",0.943673770281716,0.748017878925273,-0.325283962451648,-5.88827849469524,-0.23761464786314,"VTI1A","vesicle transport through interaction with t-SNAREs 1A",TRUE
+"235923_at",0.968451827985008,0.851926683068425,0.188853661438586,-5.92232694577854,0.0577693903835605,"VTI1A","vesicle transport through interaction with t-SNAREs 1A",TRUE
+"225928_at",0.627053909308516,0.0978972504775033,-1.72802760135243,-4.58135621231445,-0.624924545067097,"VTI1B","vesicle transport through interaction with t-SNAREs 1B",TRUE
+"225926_at",0.651040858265466,0.120811651309804,-1.61339645471408,-4.74561775500474,-0.523729789236139,"VTI1B","vesicle transport through interaction with t-SNAREs 1B",TRUE
+"209452_s_at",0.839519981963042,0.427354024656841,-0.808580003769208,-5.62616131876719,-0.243908282655347,"VTI1B","vesicle transport through interaction with t-SNAREs 1B",TRUE
+"225983_s_at",0.628680114171121,0.0997379297726621,-1.71802239807496,-4.59603151650005,-1.09346914246234,"VWA1","von Willebrand factor A domain containing 1",TRUE
+"222723_at",0.812302873476553,0.360447904552192,0.933849182444266,-5.52362664533058,0.698535623071981,"VWA1","von Willebrand factor A domain containing 1",TRUE
+"218731_s_at",0.815775199549376,0.366710143523832,0.921509627553705,-5.53433242756714,0.813633797230741,"VWA1","von Willebrand factor A domain containing 1",TRUE
+"228651_at",0.837368340567858,0.420690020258035,0.820466456486345,-5.61702282988812,0.332015860387171,"VWA1","von Willebrand factor A domain containing 1",TRUE
+"222724_at",0.88166256834198,0.538551338960342,0.624695561081759,-5.75137653670648,0.438039577011939,"VWA1","von Willebrand factor A domain containing 1",TRUE
+"1553657_at",0.833430578034454,0.410906193490041,0.838133995420412,-5.60320908790672,0.417661031206425,"VWA3A","von Willebrand factor A domain containing 3A",TRUE
+"238864_at",0.958723944343516,0.812780593094879,-0.23968150032774,-5.91174172762081,-0.145960986224639,"VWA3A","von Willebrand factor A domain containing 3A",TRUE
+"1558470_at",0.605948005391914,0.0794742230757278,1.8382262963995,-4.41559729211433,1.19658258172884,"VWA3B","von Willebrand factor A domain containing 3B",TRUE
+"1564598_a_at",0.810403302881961,0.35444862995294,0.945806185558771,-5.51312799098393,0.462284942583147,"VWA3B","von Willebrand factor A domain containing 3B",TRUE
+"1562371_s_at",0.813065886130395,0.362656934473797,-0.929480104022588,-5.5274322306127,-0.628133429787712,"VWA3B","von Willebrand factor A domain containing 3B",TRUE
+"1555298_a_at",0.92781038684564,0.683427682536202,0.413205580143821,-5.85686330949553,0.234858310761157,"VWA3B","von Willebrand factor A domain containing 3B",TRUE
+"1561200_at",0.967315591387789,0.847132722711113,-0.195048195173873,-5.92117071845652,-0.161019535350875,"VWA3B","von Willebrand factor A domain containing 3B",TRUE
+"210102_at",0.872698289258946,0.516905983770007,0.658651973636828,-5.73056514777406,0.665286133502687,"VWA5A","von Willebrand factor A domain containing 5A",TRUE
+"205011_at",0.959203345279235,0.815152788403639,0.236584350103183,-5.91245821956852,0.111695114947794,"VWA5A","von Willebrand factor A domain containing 5A",TRUE
+"1552853_at",0.937623890519979,0.72356749156612,0.358222077437105,-5.87737459226376,0.223822865000594,"VWA5B1","von Willebrand factor A domain containing 5B1",TRUE
+"1552854_a_at",0.93935730555901,0.728515186604823,0.351525359921193,-5.87967561919358,0.167492308821157,"VWA5B1","von Willebrand factor A domain containing 5B1",TRUE
+"1554850_at",0.702809964629668,0.174506726196906,1.40289328653849,-5.02402073984066,0.709195644715628,"VWA5B2","von Willebrand factor A domain containing 5B2",TRUE
+"232642_at",0.860085676417428,0.478659659473133,-0.720650322349862,-5.68985067247352,-0.399446046756104,"VWA5B2","von Willebrand factor A domain containing 5B2",TRUE
+"221301_at",0.83176405048326,0.406652502483581,0.845898395463379,-5.59705135287159,0.324314187409149,"VWA7","von Willebrand factor A domain containing 7",TRUE
+"214231_s_at",0.895690630367785,0.576150366139806,0.567394841245059,-5.78408474265515,0.221635068799176,"VWA8","von Willebrand factor A domain containing 8",TRUE
+"212946_at",0.897300940949134,0.583512299139396,0.556402244641946,-5.79001137058643,0.239046472227525,"VWA8","von Willebrand factor A domain containing 8",TRUE
+"1557647_a_at",0.678611044120554,0.146210116136079,1.50592836330542,-4.89163716252499,1.54094240392098,"VWA8-AS1","VWA8 antisense RNA 1 (head to head)",TRUE
+"1557646_at",0.70573152022539,0.178066959746158,1.39090225628523,-5.0389276840281,0.849034209276192,"VWA8-AS1","VWA8 antisense RNA 1 (head to head)",TRUE
+"221265_s_at",0.640067422642767,0.110804538734591,-1.66097769214021,-4.6784763949024,-0.51643680630619,"VWA9","von Willebrand factor A domain containing 9",TRUE
+"1568801_at",0.778112445508562,0.29745456284544,1.0670135743635,-5.39986435392592,0.559894555485268,"VWA9","von Willebrand factor A domain containing 9",TRUE
+"243734_x_at",0.790168416221247,0.319319088365952,-1.01874634010791,-5.44644804335383,-1.1200920522775,"VWC2","von Willebrand factor C domain containing 2",TRUE
+"242957_at",0.895213601869362,0.57309326247868,0.571980367809179,-5.78157924541721,0.45175996985303,"VWCE","von Willebrand factor C and EGF domains",TRUE
+"239552_at",0.769258076576208,0.276630077787521,1.11540229629107,-5.35123043248787,1.65993929992512,"VWDE","von Willebrand factor D and EGF domains",TRUE
+"1562226_at",0.784552021081681,0.308309249691658,1.04274869149763,-5.42352537629123,1.31271635839022,"VWDE","von Willebrand factor D and EGF domains",TRUE
+"233980_s_at",0.719412173140763,0.195429532882014,-1.33500813089818,-5.10700730315112,-0.654284623960824,"VWF","von Willebrand factor",TRUE
+"202112_at",0.97979222603145,0.903468515410345,0.122677402853292,-5.9323559621417,0.0945151962075155,"VWF","von Willebrand factor",TRUE
+"222390_at",0.710372201621696,0.183141856663641,-1.37413507436937,-5.05959439885196,-0.435219145730622,"WAC","WW domain containing adaptor with coiled-coil",TRUE
+"242427_at",0.718706241731185,0.194591897912603,-1.33761294084739,-5.10388651540886,-0.72231142558922,"WAC","WW domain containing adaptor with coiled-coil",TRUE
+"217742_s_at",0.76029267756668,0.2588111463585,-1.15896012658433,-5.3058207659005,-0.329198226024621,"WAC","WW domain containing adaptor with coiled-coil",TRUE
+"222389_s_at",0.801086839730802,0.337428694177919,-0.980492472205404,-5.48198109556137,-0.275665740149121,"WAC","WW domain containing adaptor with coiled-coil",TRUE
+"230154_at",0.860714927752408,0.480591013206746,-0.717452810148522,-5.69203582385968,-0.325881577225445,"WAC","WW domain containing adaptor with coiled-coil",TRUE
+"219679_s_at",0.881970070870254,0.53927669648069,-0.623570572335065,-5.75204789310536,-0.208159888051219,"WAC","WW domain containing adaptor with coiled-coil",TRUE
+"233013_x_at",0.9181984176728,0.652862831427165,-0.455950752094527,-5.8389315333449,-0.139001928758738,"WAC-AS1","WAC antisense RNA 1 (head to head)",TRUE
+"212267_at",0.712975827977365,0.187343909873776,-1.36052804140162,-5.07621273633737,-0.448884762030794,"WAPL","WAPL cohesin release factor",TRUE
+"212264_s_at",0.812302873476553,0.35875375942889,-0.93721209111854,-5.52068629277124,-0.333635528088536,"WAPL","WAPL cohesin release factor",TRUE
+"217218_at",0.899061060612873,0.589252301370635,0.547879353098194,-5.7945290052119,0.377138786181043,"WAPL","WAPL cohesin release factor",TRUE
+"1554441_a_at",0.919695424525124,0.658677270791053,-0.447754953470867,-5.84250383226684,-0.137974361063861,"WAPL","WAPL cohesin release factor",TRUE
+"200629_at",0.835973067952943,0.417222995846378,-0.826697231548665,-5.61218260038793,-0.278402670652049,"WARS","tryptophanyl-tRNA synthetase",TRUE
+"200628_s_at",0.999503346640971,0.998663201120741,-0.00169443455879422,-5.93968208233812,-0.000497529095339289,"WARS","tryptophanyl-tRNA synthetase",TRUE
+"218766_s_at",0.738726167317415,0.225426557130965,-1.24697865407803,-5.20943594357903,-0.45601739918572,"WARS2","tryptophanyl tRNA synthetase 2, mitochondrial",TRUE
+"1561297_at",0.774230543658252,0.287016107233916,1.0909521397101,-5.37604458867134,0.443450132217503,"WARS2","tryptophanyl tRNA synthetase 2, mitochondrial",TRUE
+"222734_at",0.896937351221015,0.582111110575702,0.558489080076383,-5.78889490904919,0.221861573741522,"WARS2","tryptophanyl tRNA synthetase 2, mitochondrial",TRUE
+"205400_at",0.835952408568777,0.416225153575467,-0.828496543916024,-5.61077846874174,-0.627455433753808,"WAS","Wiskott-Aldrich syndrome",TRUE
+"38964_r_at",0.978255630670068,0.894763216237906,-0.133806899354514,-5.93096672374818,-0.0535806504305398,"WAS","Wiskott-Aldrich syndrome",TRUE
+"204165_at",0.947139951418903,0.760006183158038,-0.309269425629341,-5.89320414748527,-0.13694992356587,"WASF1","WAS protein family member 1",TRUE
+"224562_at",0.565043084457947,0.0561548092817226,2.01537182585082,-4.13410100295236,0.634074030091053,"WASF2","WAS protein family member 2",TRUE
+"221725_at",0.62179111032845,0.0921501196049556,1.76033681424537,-4.53353492394577,0.579307678960577,"WASF2","WAS protein family member 2",TRUE
+"224563_at",0.643515428391208,0.11387178559803,1.64602253897697,-4.69974068390364,0.758638823668948,"WASF2","WAS protein family member 2",TRUE
+"204042_at",0.774360462422895,0.290549020171496,-1.08278109745623,-5.38422811260423,-1.12138091139227,"WASF3","WAS protein family member 3",TRUE
+"225995_x_at",0.85334340854827,0.460498723867114,0.751095609367176,-5.66858267466321,0.203538056590062,"WASH1///WASH2P","WAS protein family homolog 1///WAS protein family homolog 2 pseudogene",TRUE
+"1568838_at",0.690381347688918,0.16007774420982,-1.45359272779157,-4.95983288419875,-1.44073510816987,"WASIR2","WASH and IL9R antisense RNA 2",TRUE
+"205810_s_at",0.860085676417428,0.47886159554546,0.720315648968951,-5.69007981834,0.485908577241467,"WASL","Wiskott-Aldrich syndrome like",TRUE
+"224813_at",0.931370027472813,0.696654917930623,0.394951802555394,-5.86399226920907,0.169160963175946,"WASL","Wiskott-Aldrich syndrome like",TRUE
+"205809_s_at",0.979976490833035,0.9045510482495,0.121294551161287,-5.93252016827129,0.0561655278948834,"WASL","Wiskott-Aldrich syndrome like",TRUE
+"230340_s_at",0.985760151191312,0.931274368760771,0.0872273078454515,-5.93597829000563,0.0394847342772131,"WASL","Wiskott-Aldrich syndrome like",TRUE
+"217821_s_at",0.866077812635028,0.496787949749519,0.690925347378644,-5.709807332957,0.24276637977823,"WBP11","WW domain binding protein 11",TRUE
+"217822_at",0.873714994839466,0.519516993514844,0.654515167801064,-5.73315710455144,0.20986580768375,"WBP11","WW domain binding protein 11",TRUE
+"244647_at",0.915123892058533,0.642260732277679,-0.4709775673824,-5.83221691605556,-0.272618667207436,"WBP11","WW domain binding protein 11",TRUE
+"202808_at",0.971216837324271,0.862377951966932,-0.175374835560509,-5.92471429822319,-0.0568688297232889,"WBP1L","WW domain binding protein 1-like",TRUE
+"209117_at",0.995375928428862,0.978475924310999,-0.0272859664159552,-5.93932085708318,-0.0103845034496963,"WBP2","WW domain binding protein 2",TRUE
+"1552514_at",0.938500267760216,0.726485120503726,-0.354271060006598,-5.87873737098671,-0.264372688076312,"WBP2NL","WBP2 N-terminal like",TRUE
+"203598_s_at",0.694819513561858,0.164355972538094,1.43818968351062,-4.97953093112146,0.482522380548362,"WBP4","WW domain binding protein 4",TRUE
+"203597_s_at",0.814439884224271,0.365343714839337,0.924190053662095,-5.53201803457988,0.378632512796225,"WBP4","WW domain binding protein 4",TRUE
+"203599_s_at",0.820536502908875,0.380092687989496,0.895601724874745,-5.5563826011221,0.307514558450864,"WBP4","WW domain binding protein 4",TRUE
+"227434_at",0.726535590042475,0.205556514920422,1.30418645376826,-5.14354482113141,0.591666112587446,"WBSCR17","Williams-Beuren syndrome chromosome region 17",TRUE
+"231415_at",0.668620158511127,0.134959159932854,1.55145945397627,-4.83074142311218,0.753158396001081,"WBSCR22","Williams-Beuren syndrome chromosome region 22",TRUE
+"207628_s_at",0.754513748034606,0.247936148264582,-1.18664445368773,-5.27616657796316,-0.41111990280784,"WBSCR22","Williams-Beuren syndrome chromosome region 22",TRUE
+"1553778_at",0.948429371744093,0.765396884928832,-0.302095341325947,-5.89533081580158,-0.134209392767634,"WBSCR27","Williams Beuren syndrome chromosome region 27",TRUE
+"238258_at",0.775351898377291,0.292209162777401,-1.07896613480754,-5.38803010423577,-0.63357713551835,"WBSCR28","Williams-Beuren syndrome chromosome region 28",TRUE
+"219120_at",0.729083413548563,0.211186846963741,1.28755818817047,-5.16295657616728,0.423464350895816,"WDCP","WD repeat and coiled coil containing",TRUE
+"224800_at",0.858959381971241,0.475251582332182,-0.72631110810893,-5.68595948641899,-0.212602098004396,"WDFY1","WD repeat and FYVE domain containing 1",TRUE
+"233559_s_at",0.9802233499944,0.907287565502961,0.117799936330728,-5.93292685031957,0.0416080682486086,"WDFY1","WD repeat and FYVE domain containing 1",TRUE
+"1560112_at",0.770904853495616,0.279415116263788,1.1087814568896,-5.35799805134671,0.733027632516381,"WDFY2","WD repeat and FYVE domain containing 2",TRUE
+"243514_at",0.828307169151435,0.398102529327141,0.861663352685745,-5.58438575527405,0.488002873152662,"WDFY2","WD repeat and FYVE domain containing 2",TRUE
+"227490_at",0.82935118356643,0.400576242443937,0.857080028698692,-5.58809046964067,0.345411744082766,"WDFY2","WD repeat and FYVE domain containing 2",TRUE
+"228159_at",0.872847039074404,0.517167388486317,0.658237292108424,-5.73082567693249,0.221130669648129,"WDFY2","WD repeat and FYVE domain containing 2",TRUE
+"212602_at",0.522667179791589,0.0383565076369795,-2.20213920083311,-3.8189582809891,-0.619401863926555,"WDFY3","WD repeat and FYVE domain containing 3",TRUE
+"238660_at",0.731604348688953,0.21536665737812,-1.27543411078396,-5.17697654119813,-0.398881917758854,"WDFY3","WD repeat and FYVE domain containing 3",TRUE
+"212606_at",0.927552865877291,0.682563548343977,-0.414403013877308,-5.85638457985674,-0.169982482978558,"WDFY3","WD repeat and FYVE domain containing 3",TRUE
+"212598_at",0.942303845415102,0.740694109650561,0.335109994905958,-5.88513444774869,0.144270160417572,"WDFY3","WD repeat and FYVE domain containing 3",TRUE
+"241401_at",0.0952827619788257,0.000397764395321752,-4.16549081543398,0.156621168420987,-2.51411196587861,"WDFY3-AS2","WDFY3 antisense RNA 2",TRUE
+"238081_at",0.143584894219334,0.000982181077970384,-3.79551310909544,-0.640721550473089,-1.73715620982244,"WDFY3-AS2","WDFY3 antisense RNA 2",TRUE
+"1562953_s_at",0.74377417656369,0.234570847524432,-1.2219422988285,-5.23747405665276,-0.857396500439152,"WDFY3-AS2","WDFY3 antisense RNA 2",TRUE
+"1553863_at",0.908367146600979,0.619159970067866,0.504110344057637,-5.81665974883251,0.293106283291469,"WDFY4","WDFY family member 4",TRUE
+"229597_s_at",0.94118897722809,0.736489002047163,-0.340767012931206,-5.8832823856444,-0.190982433308126,"WDFY4","WDFY family member 4",TRUE
+"204727_at",0.79983887115773,0.335241208228806,-0.985036624719235,-5.4778248312196,-0.44040865666451,"WDHD1","WD repeat and HMG-box DNA binding protein 1",TRUE
+"204728_s_at",0.898405288322584,0.587704277622083,-0.550173831285244,-5.79331945798722,-0.182657668183358,"WDHD1","WD repeat and HMG-box DNA binding protein 1",TRUE
+"216228_s_at",0.914242258486146,0.63947654858224,0.474941882811032,-5.83040996168938,0.163456739035791,"WDHD1","WD repeat and HMG-box DNA binding protein 1",TRUE
+"231770_x_at",0.87045636854107,0.509105029315266,0.6710811326466,-5.72268338797721,0.209827082986103,"WDPCP","WD repeat containing planar cell polarity effector",TRUE
+"224180_x_at",0.927822034838128,0.683474353454787,0.413140925593086,-5.85688911937529,0.133335100632046,"WDPCP","WD repeat containing planar cell polarity effector",TRUE
+"210936_at",0.249915720062876,0.00348305036466231,-3.26960113518697,-1.7545016178676,-1.3012001562733,"WDR1","WD repeat domain 1",TRUE
+"200611_s_at",0.768852835478002,0.27366100353922,-1.12251434424801,-5.34392095898559,-0.400806722450183,"WDR1","WD repeat domain 1",TRUE
+"200609_s_at",0.812302873476553,0.359118908438712,-0.936486363630236,-5.52132165269359,-0.345556463819275,"WDR1","WD repeat domain 1",TRUE
+"210935_s_at",0.909304648717545,0.623402508937576,-0.497983465765074,-5.8196143944769,-0.248034507626102,"WDR1","WD repeat domain 1",TRUE
+"240282_at",0.99186228645105,0.962414005031146,0.0476602555386989,-5.93857717742901,0.0324655987110587,"WDR1","WD repeat domain 1",TRUE
+"229694_at",0.744152356003007,0.234972844608856,1.22085878198467,-5.23867639915528,0.825790621630619,"WDR11","WD repeat domain 11",TRUE
+"218090_s_at",0.807084045192774,0.348306673920354,0.958189950935344,-5.50212559073692,0.32039860085464,"WDR11","WD repeat domain 11",TRUE
+"1563916_at",0.923935703779429,0.672980505311155,0.427724144065739,-5.85096699471521,0.189930355415666,"WDR11-AS1","WDR11 antisense RNA 1",TRUE
+"1562831_a_at",0.980009054680439,0.905920390075823,0.119545669861239,-5.93272517642787,0.0342285136149236,"WDR11-AS1","WDR11 antisense RNA 1",TRUE
+"238826_x_at",0.854040699678541,0.46334822427735,-0.746272186019506,-5.67200777276763,-0.655330885001643,"WDR12","WD repeat domain 12",TRUE
+"241687_at",0.947969282616012,0.763726762514451,-0.304316235609356,-5.89467774550448,-0.132792362768125,"WDR12","WD repeat domain 12",TRUE
+"218512_at",0.994701128358967,0.975333143623311,0.0312713252545746,-5.93920719499205,0.00954495648966791,"WDR12","WD repeat domain 12",TRUE
+"222138_s_at",0.982158015263164,0.9141479513256,-0.109045518938306,-5.93389350858455,-0.0370874887865291,"WDR13","WD repeat domain 13",TRUE
+"238782_at",0.997056683282451,0.985118176961577,-0.018864337879765,-5.93951015437007,-0.00726122281498132,"WDR13","WD repeat domain 13",TRUE
+"1557132_at",0.82706053436911,0.395555765048216,0.86640122917326,-5.58053679147494,1.26893159562328,"WDR17","WD repeat domain 17",TRUE
+"1552430_at",0.937623890519979,0.723754883450825,0.357968139619431,-5.87746262902727,0.410712054135185,"WDR17","WD repeat domain 17",TRUE
+"209461_x_at",0.94895689004559,0.7679765629233,-0.298667979755327,-5.89632935105694,-0.139690294376479,"WDR18","WD repeat domain 18",TRUE
+"220917_s_at",0.804537788156734,0.343272594665374,0.968451005031085,-5.49290996797225,0.44013023010211,"WDR19","WD repeat domain 19",TRUE
+"232163_at",0.842917136850585,0.43671826043464,0.792070444934367,-5.63864627436243,0.705699047016181,"WDR19","WD repeat domain 19",TRUE
+"1555314_at",0.999419542722695,0.998213110352879,-0.00226493963237922,-5.93968098213916,-0.00210871296952986,"WDR19","WD repeat domain 19",TRUE
+"227541_at",0.594005743610726,0.0709465788216176,-1.89694350482019,-4.32428316064066,-0.733765364781638,"WDR20","WD repeat domain 20",TRUE
+"227693_at",0.690381347688918,0.160114908912759,-1.45345749995445,-4.96000656231242,-0.462773115325968,"WDR20","WD repeat domain 20",TRUE
+"1554549_a_at",0.835838027302116,0.41542579285905,-0.82993991762499,-5.60965003669797,-0.328951990472284,"WDR20","WD repeat domain 20",TRUE
+"223293_at",0.51531387545335,0.0359561151459051,-2.23312499751864,-3.7649938405847,-0.733629195494714,"WDR24","WD repeat domain 24",TRUE
+"219609_at",0.366473876333673,0.0107889696387781,-2.78351259296397,-2.739498267598,-1.8531332584599,"WDR25","WD repeat domain 25",TRUE
+"218107_at",0.594303508881191,0.0712022321333208,-1.89509566498267,-4.32718760249209,-0.614920240184274,"WDR26","WD repeat domain 26",TRUE
+"224898_at",0.603702127972549,0.0782515079479066,-1.84629754931608,-4.40316604035149,-0.811507925074407,"WDR26","WD repeat domain 26",TRUE
+"224905_at",0.630132423960255,0.101303725550754,-1.70963447731396,-4.60828557026394,-0.749276164146266,"WDR26","WD repeat domain 26",TRUE
+"224897_at",0.657015752622694,0.125575373377855,-1.59189740206589,-4.77545986123796,-0.758067667564173,"WDR26","WD repeat domain 26",TRUE
+"223863_at",0.782471668844017,0.30485983520284,1.05039290827601,-5.41612412572955,0.741313090553329,"WDR26","WD repeat domain 26",TRUE
+"235298_at",0.590614892048442,0.0683568548126665,1.91599835922734,-4.29421769099312,0.55251122170456,"WDR27","WD repeat domain 27",TRUE
+"238239_at",0.774230543658252,0.289205697478,1.08587950475122,-5.38113142916649,0.689004814250712,"WDR27","WD repeat domain 27",TRUE
+"238074_at",0.846311252145305,0.444323081716159,0.778822613356748,-5.64848928587379,0.358401176141266,"WDR27","WD repeat domain 27",TRUE
+"228326_at",0.85334340854827,0.460894797728493,0.750424100671587,-5.66906076316065,0.476860993358913,"WDR27","WD repeat domain 27",TRUE
+"235576_at",0.956752747974222,0.804127279884031,0.250999902294576,-5.90904454140841,0.140060828358043,"WDR27","WD repeat domain 27",TRUE
+"1557593_at",0.724697226571437,0.202206871514097,-1.31424747984779,-5.13169719562321,-0.440104551200934,"WDR3","WD repeat domain 3",TRUE
+"218882_s_at",0.940567117317801,0.733896301782737,-0.344260549635765,-5.88212331763552,-0.153768114582524,"WDR3","WD repeat domain 3",TRUE
+"229516_at",0.783963982912486,0.307009293970265,1.04562236712623,-5.420748740459,0.566222600553453,"WDR31","WD repeat domain 31",TRUE
+"241919_x_at",0.78969417320323,0.317646209923601,1.02235550749867,-5.4430320063097,0.312381279733247,"WDR31","WD repeat domain 31",TRUE
+"224715_at",0.808363209285429,0.351362627684833,-0.952010037532361,-5.5076325415995,-0.355862779314178,"WDR34","WD repeat domain 34",TRUE
+"226890_at",0.837368340567858,0.420645314052544,-0.82054659463312,-5.61696079421034,-0.386975575879617,"WDR35","WD repeat domain 35",TRUE
+"226889_at",0.99420041915836,0.97359814984137,0.0334716882914581,-5.93913781239585,0.0143967032211183,"WDR35","WD repeat domain 35",TRUE
+"238677_at",0.666473481658155,0.133228539887124,1.55873821675418,-4.82087332989243,0.634555293198893,"WDR36","WD repeat domain 36",TRUE
+"226180_at",0.957345379847178,0.806884129750665,0.247390417698606,-5.90991811965601,0.0802625257181582,"WDR36","WD repeat domain 36",TRUE
+"211383_s_at",0.929234395612144,0.688863338809189,-0.405687358778925,-5.85983792165393,-0.139585462881566,"WDR37","WD repeat domain 37",TRUE
+"1554869_at",0.97689149311934,0.889753777716378,-0.140219097113103,-5.93011167492731,-0.0482820701841344,"WDR37","WD repeat domain 37",TRUE
+"242255_at",0.985498770484702,0.930030420644646,-0.0888104457747682,-5.93584260005962,-0.0329835157306357,"WDR37","WD repeat domain 37",TRUE
+"244109_at",0.858400984062047,0.474173324565925,0.728107035157758,-5.68471893236051,0.429605427864528,"WDR38","WD repeat domain 38",TRUE
+"243900_at",0.871451481476429,0.512357350514304,0.665886446877686,-5.72599468908407,0.209607063940023,"WDR38","WD repeat domain 38",TRUE
+"241937_s_at",0.557512088623721,0.0523470746562335,2.05032720999235,-4.07649202717704,1.46234038308312,"WDR4","WD repeat domain 4",TRUE
+"226882_x_at",0.575270671804438,0.0608160124769882,1.97534416887919,-4.19925651236829,1.27269686842906,"WDR4","WD repeat domain 4",TRUE
+"221632_s_at",0.801917957653237,0.339605094438507,0.9759913860118,-5.4860807077003,0.306736626427433,"WDR4","WD repeat domain 4",TRUE
+"218055_s_at",0.527546822913581,0.0402450604901496,-2.1789749632868,-3.85899926843435,-1.16731477312175,"WDR41","WD repeat domain 41",TRUE
+"222503_s_at",0.689848451630875,0.158742765596877,-1.45846710357704,-4.95356377809121,-0.625717920179682,"WDR41","WD repeat domain 41",TRUE
+"240637_at",0.727063903913962,0.207168332127583,-1.29939051994631,-5.1491652581655,-1.30865958241652,"WDR41","WD repeat domain 41",TRUE
+"214662_at",0.677013732819214,0.143919946145517,1.51495724514624,-4.87967629188152,0.553484256464943,"WDR43","WD repeat domain 43",TRUE
+"219297_at",0.818487964975398,0.371721530101584,0.911735660363524,-5.54271919768899,0.287442194433437,"WDR44","WD repeat domain 44",TRUE
+"235485_at",0.921312278448293,0.664478567284744,0.439608610260612,-5.84599158485882,0.30702003031497,"WDR44","WD repeat domain 44",TRUE
+"209217_s_at",0.727286289873957,0.207461122672265,-1.29852243599391,-5.15018070407264,-0.364811993654527,"WDR45","WD repeat domain 45",TRUE
+"209216_at",0.799150634740328,0.333814471610757,-0.988011448303848,-5.47509446525433,-0.324034593858848,"WDR45","WD repeat domain 45",TRUE
+"209076_s_at",0.830635993561085,0.404476869160135,-0.849889668038148,-5.59386536576211,-0.246410749465808,"WDR45B","WD repeat domain 45B",TRUE
+"209196_at",0.977930820766623,0.893437528827113,0.135503239835211,-5.93074440731438,0.0535855576799769,"WDR46","WD repeat domain 46",TRUE
+"203855_at",0.903383391791809,0.6035443719318,-0.526833453168794,-5.80539414529459,-0.203005323849384,"WDR47","WD repeat domain 47",TRUE
+"221735_at",0.64513208805899,0.115780795701033,1.63688499285078,-4.71266061173867,0.546505093844004,"WDR48","WD repeat domain 48",TRUE
+"65591_at",0.70190082585548,0.173425645865645,1.4065730077262,-5.01942503127966,0.400331589292964,"WDR48","WD repeat domain 48",TRUE
+"56919_at",0.740610299769501,0.23009015334073,-1.23411557708155,-5.22390247911974,-0.502891914900111,"WDR48","WD repeat domain 48",TRUE
+"222157_s_at",0.774230543658252,0.289089182256647,1.08614873780888,-5.38086197323648,0.336750261724834,"WDR48","WD repeat domain 48",TRUE
+"1564238_a_at",0.822241803732333,0.387015861229387,-0.882434086974399,-5.56736658325745,-0.617775477366102,"WDR49","WD repeat domain 49",TRUE
+"1554298_a_at",0.877510999184545,0.52773863986013,0.641563229380086,-5.74117087874969,0.557564609691521,"WDR49","WD repeat domain 49",TRUE
+"223308_s_at",0.834881450121645,0.413531305225547,-0.83336773871421,-5.60696279830239,-0.325509888302271,"WDR5","WD repeat domain 5",TRUE
+"225170_at",0.904832003218088,0.609766096122072,-0.517746867523506,-5.80995714091825,-0.177745033648412,"WDR5","WD repeat domain 5",TRUE
+"227814_at",0.657015752622694,0.125293912733446,1.59314858337936,-4.77373167150457,0.573761979726029,"WDR53","WD repeat domain 53",TRUE
+"225898_at",0.941812807463266,0.73891179129299,0.337506327525144,-5.8843536512674,0.196930326795037,"WDR54","WD repeat domain 54",TRUE
+"222114_x_at",0.73957587762701,0.228081165674275,-1.23963217354632,-5.21771402001011,-0.925436382914868,"WDR55","WD repeat domain 55",TRUE
+"223833_at",0.760227035076299,0.258128345090073,-1.16067261888723,-5.30400421252041,-0.457600206134618,"WDR55","WD repeat domain 55",TRUE
+"219809_at",0.777826511138126,0.29694007361397,-1.06817922363382,-5.39871543254464,-0.325531461715144,"WDR55","WD repeat domain 55",TRUE
+"221981_s_at",0.752913428584105,0.246193231757131,-1.19116517016413,-5.27126615789219,-1.04019505811718,"WDR59","WD repeat domain 59",TRUE
+"218505_at",0.88767000285873,0.552382619704161,-0.603381071082557,-5.76389794999746,-0.202806578957048,"WDR59","WD repeat domain 59",TRUE
+"219586_at",0.94118897722809,0.736634000863605,0.340571762146514,-5.88334682004091,0.123191099877775,"WDR59","WD repeat domain 59",TRUE
+"228295_at",0.971971508470182,0.865734622606116,-0.171052961579088,-5.92544248426057,-0.0763316881337186,"WDR59","WD repeat domain 59",TRUE
+"219538_at",0.886783047600321,0.5501855697316,-0.606747782084397,-5.7619480242531,-0.214194869289679,"WDR5B","WD repeat domain 5B",TRUE
+"233573_s_at",0.892780783477555,0.566081316538291,0.582545176107943,-5.77573237739463,0.380197065995317,"WDR6","WD repeat domain 6",TRUE
+"217734_s_at",0.996261754016157,0.981402361124154,-0.0235753617079818,-5.93941277581721,-0.0149334486727,"WDR6","WD repeat domain 6",TRUE
+"229008_at",0.768852835478002,0.273169393379752,-1.1236973637162,-5.34270111160832,-0.639896746701591,"WDR60","WD repeat domain 60",TRUE
+"219251_s_at",0.819807973515613,0.377729382800832,-0.90013264027972,-5.55256825539528,-0.522773773005252,"WDR60","WD repeat domain 60",TRUE
+"1562516_at",0.880851312840243,0.536759454776376,0.627478161304723,-5.74971096690762,0.630529190170976,"WDR60","WD repeat domain 60",TRUE
+"221532_s_at",0.552420073963858,0.0495230484955289,-2.07775044709916,-4.03084259974874,-0.838686830767321,"WDR61","WD repeat domain 61",TRUE
+"221531_at",0.557512088623721,0.0523396837140313,-2.05039723670926,-4.076375963646,-0.814346038128944,"WDR61","WD repeat domain 61",TRUE
+"237208_at",0.671655467883069,0.137742491813175,-1.53991313964633,-4.84632032181528,-0.833434710685856,"WDR61","WD repeat domain 61",TRUE
+"215156_at",0.819146035424223,0.375451296712044,-0.904517880289339,-5.54885960346681,-0.252470643485583,"WDR61","WD repeat domain 61",TRUE
+"232075_at",0.957571530817866,0.808555152408475,0.245204220635373,-5.91044111283908,0.138113753972467,"WDR61","WD repeat domain 61",TRUE
+"215218_s_at",0.565956563686213,0.0568110150755193,-2.00956220918019,-4.1436119546202,-0.682505297433528,"WDR62","WD repeat domain 62",TRUE
+"1553125_x_at",0.729210170056086,0.211300900305415,1.28722491459237,-5.16334347442389,0.477056154394887,"WDR62","WD repeat domain 62",TRUE
+"1553123_at",0.761006638483723,0.260127170857289,1.15566890042907,-5.30930537620833,0.367845038620294,"WDR62","WD repeat domain 62",TRUE
+"243087_at",0.741143136625128,0.231377320937893,1.23060028460806,-5.22783348399231,0.653509142947257,"WDR63","WD repeat domain 63",TRUE
+"1553373_at",0.7083523771159,0.180337813699223,1.38335320706927,-5.04825813992602,0.508863831719138,"WDR64","WD repeat domain 64",TRUE
+"1555007_s_at",0.404266019372898,0.0150393613791399,2.63593253672707,-3.02560898168855,1.64115039927378,"WDR66","WD repeat domain 66",TRUE
+"230193_at",0.56861088242915,0.0584314737074034,1.99546721236742,-4.16661064382551,2.10321458032782,"WDR66","WD repeat domain 66",TRUE
+"1555006_at",0.997455125469763,0.987038172993435,-0.0164302871190877,-5.93955199680108,-0.0125468323181783,"WDR66","WD repeat domain 66",TRUE
+"237122_at",0.47984873377716,0.0269878365096025,2.36862553599619,-3.5238093365584,1.06839545424651,"WDR7","WD repeat domain 7",TRUE
+"212880_at",0.564004192185035,0.0559512447066606,-2.01718632573474,-4.1311267302237,-0.889932363543984,"WDR7","WD repeat domain 7",TRUE
+"219193_at",0.42327301158031,0.0177360488254319,2.56158927547262,-3.16691466466935,0.835611881840954,"WDR70","WD repeat domain 70",TRUE
+"1563874_at",0.838245037296515,0.422899884219906,0.816511799943071,-5.62007711169723,0.365511018320799,"WDR72","WD repeat domain 72",TRUE
+"227174_at",0.869441836317963,0.506629845978307,0.675047015498679,-5.72013879312531,0.816038785687959,"WDR72","WD repeat domain 72",TRUE
+"236741_at",0.875990189898743,0.524536677221673,0.646594190059488,-5.738076333109,0.733523190059182,"WDR72","WD repeat domain 72",TRUE
+"238253_at",0.943670363202696,0.747997918618718,0.325310697673038,-5.8882700658236,0.232891033708219,"WDR72","WD repeat domain 72",TRUE
+"213031_s_at",0.805746717966166,0.345778076967959,-0.963331317642287,-5.49751925820214,-0.355163243375873,"WDR73","WD repeat domain 73",TRUE
+"240672_at",0.876632890672003,0.525562862795383,0.64498001279126,-5.73907174404023,0.221276548457483,"WDR74","WD repeat domain 74",TRUE
+"221712_s_at",0.935094665155941,0.711513330952465,-0.374608261820012,-5.87156343389342,-0.142425164365299,"WDR74","WD repeat domain 74",TRUE
+"218278_at",0.94895689004559,0.769091461322574,-0.297187857075782,-5.89675708099255,-0.0982527423468564,"WDR74","WD repeat domain 74",TRUE
+"224721_at",0.995111934465262,0.977420969267514,0.0286237006687905,-5.9392844298956,0.00952710449100813,"WDR75","WD repeat domain 75",TRUE
+"205519_at",0.789522739079031,0.316689953191445,1.02442457593754,-5.44106873362676,0.33673821564714,"WDR76","WD repeat domain 76",TRUE
+"239680_at",0.994536266629158,0.974810427801586,-0.0319342295301191,-5.93918678840314,-0.0173352980630295,"WDR76","WD repeat domain 76",TRUE
+"201420_s_at",0.740852596040428,0.231146019906597,-1.23123087798985,-5.22712902961486,-0.495196241392204,"WDR77","WD repeat domain 77",TRUE
+"201421_s_at",0.96479405380661,0.83714302161206,-0.207981858262075,-5.9186367917214,-0.0811292674037603,"WDR77","WD repeat domain 77",TRUE
+"1554141_s_at",0.737037362362438,0.222412225744843,1.25540114126037,-5.19989372184413,1.01856872030609,"WDR78","WD repeat domain 78",TRUE
+"229816_at",0.762857166457304,0.26249181253674,1.1497860110623,-5.31551224059594,1.04208776168811,"WDR78","WD repeat domain 78",TRUE
+"1554140_at",0.837368340567858,0.421060734051211,0.819802138941859,-5.61753686563362,0.912562977658028,"WDR78","WD repeat domain 78",TRUE
+"1559576_at",0.85334340854827,0.460955675023805,0.75032091910525,-5.66913418859655,0.305926722736535,"WDR78","WD repeat domain 78",TRUE
+"220769_s_at",0.864894115958506,0.493962742590838,0.695516312560089,-5.70677740266017,0.262108245438569,"WDR78","WD repeat domain 78",TRUE
+"226738_at",0.938400005975956,0.726277514036904,0.354552007546462,-5.87864096011233,0.176986528828529,"WDR81","WD repeat domain 81",TRUE
+"201934_at",0.740321726337106,0.228849984968393,-1.2375166781354,-5.22008997083967,-0.468190801565909,"WDR82","WD repeat domain 82",TRUE
+"224434_s_at",0.988048777859258,0.942798222033752,0.072571530151637,-5.93711862644999,0.0195722741317343,"WDR83","WD repeat domain 83",TRUE
+"217780_at",0.953564723226096,0.786176229463181,0.27458875812932,-5.90302599355568,0.0984021691082511,"WDR83OS","WD repeat domain 83 opposite strand",TRUE
+"235246_at",0.579900400995893,0.0625242407658124,1.96135362674224,-4.22182149857097,1.43821254112595,"WDR86","WD repeat domain 86",TRUE
+"243526_at",0.633411263775153,0.104666581068037,1.69198611731931,-4.63392132284869,1.5307349329408,"WDR86","WD repeat domain 86",TRUE
+"1560147_at",0.615005518451136,0.0856663892021643,1.79893356633471,-4.47555594970875,1.66768577571841,"WDR86-AS1","WDR86 antisense RNA 1",TRUE
+"224135_at",0.920119557710459,0.65985307267704,0.446101388701115,-5.84321686689423,0.219114396891976,"WDR87","WD repeat domain 87",TRUE
+"1552452_at",0.743474458360704,0.233760208775306,-1.22413152453898,-5.23504193239973,-0.633647476950589,"WDR88","WD repeat domain 88",TRUE
+"1552453_a_at",0.775581183114088,0.29288739881224,1.07741204490469,-5.38957547503215,0.383862028039091,"WDR88","WD repeat domain 88",TRUE
+"235025_at",0.767965891104819,0.270863413783006,-1.12926738738199,-5.3369424269017,-0.368899201742038,"WDR89","WD repeat domain 89",TRUE
+"238650_x_at",0.775803020497764,0.293137898499558,-1.07683871039709,-5.39014509043014,-0.299673043453785,"WDR89","WD repeat domain 89",TRUE
+"244038_at",0.995025131654789,0.976505071733103,-0.0297851465695291,-5.93925138951692,-0.00822288544233452,"WDR89","WD repeat domain 89",TRUE
+"236049_at",0.656693876264681,0.124778515684995,1.59544576662498,-4.77055594231893,0.682171930029083,"WDR90","WD repeat domain 90",TRUE
+"227894_at",0.971216837324271,0.861865629543502,-0.176034773925434,-5.92460151189688,-0.0634262023854273,"WDR90","WD repeat domain 90",TRUE
+"242211_x_at",0.974884920935236,0.876902098054312,-0.15669779248745,-5.92773110782011,-0.0573131027091485,"WDR90","WD repeat domain 90",TRUE
+"222799_at",0.914910510855952,0.641669329619208,-0.471819005274336,-5.83183462376427,-0.338633197636621,"WDR91","WD repeat domain 91",TRUE
+"230888_at",0.968451827985008,0.85160645566821,-0.189267206130819,-5.92225091477784,-0.0646941304476485,"WDR91","WD repeat domain 91",TRUE
+"218971_s_at",0.986361618040699,0.935812276408326,0.0814539445590954,-5.93645245763946,0.0440963541752186,"WDR91","WD repeat domain 91",TRUE
+"235071_at",0.778481681746654,0.298470371995696,1.06471633459869,-5.40212533837646,0.246191493229221,"WDR92","WD repeat domain 92",TRUE
+"232620_at",0.982909728377256,0.917031289314706,0.105368786428352,-5.93427726924251,0.0406505065392002,"WDR93","WD repeat domain 93",TRUE
+"233344_x_at",0.983322116265651,0.918648566561193,-0.103307145128655,-5.93448670116132,-0.067105784783835,"WDR97","WD repeat domain 97",TRUE
+"226668_at",0.984397001287044,0.923913655784301,0.0965985448942245,-5.93513958062036,0.027300452534277,"WDSUB1","WD repeat, sterile alpha motif and U-box domain containing 1",TRUE
+"216036_x_at",0.953998165840919,0.788743174918571,0.271206174909354,-5.90392199091513,0.0774864380440192,"WDTC1","WD and tetratricopeptide repeats 1",TRUE
+"215497_s_at",0.965883239653478,0.840261004314184,-0.203941215477838,-5.91944582163926,-0.141964514896662,"WDTC1","WD and tetratricopeptide repeats 1",TRUE
+"40829_at",0.97928472590149,0.899665798362292,-0.127537040082229,-5.93176416367884,-0.0359737717528841,"WDTC1","WD and tetratricopeptide repeats 1",TRUE
+"219060_at",0.947062793209778,0.759682043376467,-0.309701323758345,-5.893074538289,-0.159228572111866,"WDYHV1","WDYHV motif containing 1",TRUE
+"215711_s_at",0.918134635422754,0.652240829894014,0.456829370974253,-5.83854480053166,0.150305799390324,"WEE1","WEE1 G2 checkpoint kinase",TRUE
+"212533_at",0.935094665155941,0.711467708080236,0.374670476638222,-5.8715408814694,0.157804336860249,"WEE1","WEE1 G2 checkpoint kinase",TRUE
+"1553634_a_at",0.849935057946582,0.452118883642426,0.765384883120586,-5.65831337377725,0.556798077311373,"WEE2-AS1","WEE2 antisense RNA 1",TRUE
+"219478_at",0.988139605576153,0.943427079116246,-0.0717722620858795,-5.93717480451851,-0.034120426084665,"WFDC1","WAP four-disulfide core domain 1",TRUE
+"233913_at",0.98687728101116,0.938590145982351,-0.0779212057275981,-5.93672660522383,-0.0397808709610818,"WFDC10A","WAP four-disulfide core domain 10A",TRUE
+"1552999_a_at",0.75710709622615,0.252877204068631,1.17395630332681,-5.28983353997302,0.841219338671481,"WFDC10B","WAP four-disulfide core domain 10B",TRUE
+"1552608_at",0.535697382361465,0.0429358175070643,2.14761684469898,-3.91278522899515,1.09092305749605,"WFDC11","WAP four-disulfide core domain 11",TRUE
+"1553081_at",0.957417243518445,0.807199510639735,0.246977711208493,-5.91001720278024,0.149730650993313,"WFDC12","WAP four-disulfide core domain 12",TRUE
+"1553052_at",0.935810894498532,0.713734065040273,0.3715817143919,-5.87265607330191,0.227724554611739,"WFDC13","WAP four-disulfide core domain 13",TRUE
+"1553089_a_at",0.228900728752571,0.00288744648573358,3.3484266416749,-1.58998042821469,1.85339009275374,"WFDC2","WAP four-disulfide core domain 2",TRUE
+"203892_at",0.24598805733942,0.00336532358280541,3.2840840552001,-1.72435479087168,3.43345220697942,"WFDC2","WAP four-disulfide core domain 2",TRUE
+"1552261_at",0.61760967235709,0.0880594990876243,1.78440375869383,-4.49748996818161,1.619113341936,"WFDC2","WAP four-disulfide core domain 2",TRUE
+"229566_at",0.808257777979515,0.350535503404173,-0.953679083495079,-5.50614846188658,-1.14246421594763,"WFDC21P","WAP four-disulfide core domain 21, pseudogene",TRUE
+"232602_at",0.29806620002593,0.00546420476872257,3.07849894987012,-2.1484428945682,2.29378321872481,"WFDC3","WAP four-disulfide core domain 3",TRUE
+"242204_at",0.573427332676968,0.06024264469861,1.98011810051912,-4.19153190247163,1.71335314716716,"WFDC5","WAP four-disulfide core domain 5",TRUE
+"1552396_at",0.886940322815928,0.550629286843797,0.606067270976256,-5.76234300591529,0.387944657080554,"WFDC6","WAP four-disulfide core domain 6",TRUE
+"215276_at",0.664032017271959,0.132041263681404,1.56377709590422,-4.81402062705051,0.745449584955804,"WFDC8","WAP four-disulfide core domain 8",TRUE
+"1554157_a_at",0.729789891627758,0.212190586721102,1.28462993393312,-5.16635307939644,0.669817050273356,"WFDC8","WAP four-disulfide core domain 8",TRUE
+"1554156_a_at",0.943464796017993,0.746457691262754,-0.327374439290444,-5.88761735623853,-0.216531744663082,"WFDC8","WAP four-disulfide core domain 8",TRUE
+"1552415_a_at",0.805746717966166,0.345604646905156,0.963684887373872,-5.49720165447602,0.523666050105004,"WFDC9","WAP four-disulfide core domain 9",TRUE
+"1552414_at",0.841813886364358,0.434016396820856,0.796811280586615,-5.63508591357425,0.51872350886863,"WFDC9","WAP four-disulfide core domain 9",TRUE
+"1552811_at",0.900279385985816,0.595197054690979,-0.539095483105645,-5.79911407169543,-0.323897488725296,"WFIKKN1","WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1",TRUE
+"1554773_at",0.822850703882235,0.388239020384842,0.880123713597394,-5.56927826396887,0.338207272874095,"WFIKKN2","WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2",TRUE
+"241358_at",0.950497248455139,0.774757391397379,-0.289676238195439,-5.89889532363311,-0.200791845101977,"WFIKKN2","WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2",TRUE
+"1555270_a_at",0.457531863501901,0.0227757846578084,-2.44732169156318,-3.38006409572331,-1.2284230378783,"WFS1","wolframin ER transmembrane glycoprotein",TRUE
+"202908_at",0.518537987260825,0.0371325652390747,-2.21771102933716,-3.79189580662869,-0.997401773461927,"WFS1","wolframin ER transmembrane glycoprotein",TRUE
+"228953_at",0.392585343378161,0.0133410803474462,-2.68948570227737,-2.92261678550629,-1.62273511102921,"WHAMM","WAS protein homolog associated with actin, golgi membranes and microtubules",TRUE
+"1557450_s_at",0.863408882018863,0.487898505150711,-0.705421756475354,-5.70017484281279,-0.277486544914215,"WHAMMP2","WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 2",TRUE
+"244105_at",0.767965891104819,0.271083376199718,-1.1287345809054,-5.33749436831216,-1.06174071871363,"WHAMMP2///WHAMMP3","WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 2///WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 3",TRUE
+"1557261_at",0.922168942129244,0.66795710250754,-0.434738445358417,-5.8480466620315,-0.384656450909703,"WHAMMP2///WHAMMP3","WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 2///WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 3",TRUE
+"213908_at",0.96696492045873,0.845906394980175,-0.1966340443257,-5.92086873802252,-0.144096832683815,"WHAMMP2///WHAMMP3","WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 2///WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 3",TRUE
+"1560662_s_at",0.991215113882097,0.958767063452622,0.0522889070197087,-5.93835187467042,0.0412182555308638,"WHAMMP2///WHAMMP3","WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 2///WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 3",TRUE
+"222367_at",0.993474831312851,0.969166685910522,0.0390925780732238,-5.93893916383913,0.0244749285451435,"WHAMMP2///WHAMMP3","WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 2///WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 3",TRUE
+"221887_s_at",0.623503825356688,0.0945503747027154,-1.74663896466528,-4.5538893097827,-1.42415374161849,"WHRN","whirlin",TRUE
+"47553_at",0.897699110987203,0.585193017166103,-0.553902386279874,-5.79134345973637,-0.46931355270129,"WHRN","whirlin",TRUE
+"222777_s_at",0.69410086222651,0.163518680366627,-1.44117856356727,-4.97572200733181,-0.595674625055619,"WHSC1","Wolf-Hirschhorn syndrome candidate 1",TRUE
+"223472_at",0.703902004301726,0.175606853636351,-1.39916735842397,-5.02866403744062,-0.754258007298565,"WHSC1","Wolf-Hirschhorn syndrome candidate 1",TRUE
+"209053_s_at",0.935414597731663,0.712782502221937,-0.372878125835381,-5.87218911559012,-0.14359670953205,"WHSC1","Wolf-Hirschhorn syndrome candidate 1",TRUE
+"209054_s_at",0.93565329131222,0.713292988717001,-0.372182557037206,-5.8724398537936,-0.146928255689566,"WHSC1","Wolf-Hirschhorn syndrome candidate 1",TRUE
+"209052_s_at",0.951926058281945,0.779742352418139,-0.28308147377392,-5.90072781315439,-0.106984074695024,"WHSC1","Wolf-Hirschhorn syndrome candidate 1",TRUE
+"222778_s_at",0.95279845708016,0.783945334440139,-0.277531170916629,-5.90223762453056,-0.15629145446486,"WHSC1","Wolf-Hirschhorn syndrome candidate 1",TRUE
+"224076_s_at",0.687659256779784,0.156731709929837,-1.4658730085729,-4.94400619516341,-0.68723861451439,"WHSC1L1","Wolf-Hirschhorn syndrome candidate 1-like 1",TRUE
+"218173_s_at",0.856857560656867,0.471119745567199,-0.733206086073517,-5.68118085479625,-0.314082466806039,"WHSC1L1","Wolf-Hirschhorn syndrome candidate 1-like 1",TRUE
+"238496_at",0.870433264908839,0.508727422358785,-0.67168545654095,-5.72229656778271,-0.401146118890936,"WHSC1L1","Wolf-Hirschhorn syndrome candidate 1-like 1",TRUE
+"221248_s_at",0.879161148925378,0.532995968969904,-0.633338763046494,-5.74617970647588,-0.330199631760536,"WHSC1L1","Wolf-Hirschhorn syndrome candidate 1-like 1",TRUE
+"225318_at",0.915353407558177,0.642706851832598,-0.470343064153443,-5.83250474953841,-0.281867278219551,"WHSC1L1","Wolf-Hirschhorn syndrome candidate 1-like 1",TRUE
+"222544_s_at",0.918373706340477,0.653435279818148,-0.455142452293137,-5.83928667004689,-0.230255975252394,"WHSC1L1","Wolf-Hirschhorn syndrome candidate 1-like 1",TRUE
+"224077_at",0.978316880841318,0.895667825877261,0.132649598156864,-5.93111679121694,0.050513145570253,"WHSC1L1","Wolf-Hirschhorn syndrome candidate 1-like 1",TRUE
+"204712_at",0.959203345279235,0.815215762151594,-0.236502163622245,-5.91247710628066,-0.224599619461674,"WIF1","WNT inhibitory factor 1",TRUE
+"202664_at",0.823074246722209,0.389324231354259,0.878077869257578,-5.57096718284132,1.03527956886942,"WIPF1","WAS/WASL interacting protein family member 1",TRUE
+"202665_s_at",0.854092692629534,0.463439083126474,0.746118678287919,-5.67211643488499,0.63805645870008,"WIPF1","WAS/WASL interacting protein family member 1",TRUE
+"231182_at",0.907189812622248,0.616084038637044,0.508564708025378,-5.81448953116069,0.272386807194008,"WIPF1","WAS/WASL interacting protein family member 1",TRUE
+"202663_at",0.957342505329543,0.806864197313043,0.247416502701815,-5.90991185160787,0.343860925338488,"WIPF1","WAS/WASL interacting protein family member 1",TRUE
+"231251_at",0.624331975868069,0.0956933374888979,1.74022069880547,-4.56338612098064,0.567959627389701,"WIPF2","WAS/WASL interacting protein family member 2",TRUE
+"212050_at",0.769847953580141,0.277907748815276,1.11235891134703,-5.35434572380723,0.357112761565327,"WIPF2","WAS/WASL interacting protein family member 2",TRUE
+"212049_at",0.913342687538603,0.636792377667518,0.478771117514284,-5.82865050824844,0.200220148654186,"WIPF2","WAS/WASL interacting protein family member 2",TRUE
+"212051_at",0.936143408699214,0.715300489545096,0.369449024640888,-5.87342076049037,0.128193005270179,"WIPF2","WAS/WASL interacting protein family member 2",TRUE
+"229849_at",0.51470556386048,0.0351700369996058,2.24368232627438,-3.74650340359138,0.871024639359397,"WIPF3","WAS/WASL interacting protein family member 3",TRUE
+"232389_at",0.64484773720849,0.115208763191124,1.6396096758202,-4.70881384980251,1.10198267894747,"WIPF3","WAS/WASL interacting protein family member 3",TRUE
+"241600_at",0.798428326317339,0.332771961042364,0.990190685917258,-5.47308955513831,0.695653131609567,"WIPF3","WAS/WASL interacting protein family member 3",TRUE
+"241601_at",0.961672030655998,0.826255241190602,-0.222119797765427,-5.9156816771063,-0.158018544344618,"WIPF3","WAS/WASL interacting protein family member 3",TRUE
+"213836_s_at",0.766550448794594,0.267458981551442,-1.13755455104141,-5.32832804628903,-0.720949970266993,"WIPI1","WD repeat domain, phosphoinositide interacting 1",TRUE
+"203827_at",0.78969417320323,0.317737862722971,-1.02215742616306,-5.44321977125047,-0.627981343511737,"WIPI1","WD repeat domain, phosphoinositide interacting 1",TRUE
+"214699_x_at",0.662855903464759,0.130556473734443,1.57013170739826,-4.80535379153499,0.44721267121913,"WIPI2","WD repeat domain, phosphoinositide interacting 2",TRUE
+"204710_s_at",0.689950875648652,0.15921540078408,1.45673760561847,-4.95579009766213,0.440300420764096,"WIPI2","WD repeat domain, phosphoinositide interacting 2",TRUE
+"202031_s_at",0.748438284778152,0.241268102706167,1.20407085828989,-5.25718730625853,0.349416878027565,"WIPI2","WD repeat domain, phosphoinositide interacting 2",TRUE
+"226986_at",0.837337084923913,0.419912857334119,0.821860322648594,-5.61594301603312,0.39526433497611,"WIPI2","WD repeat domain, phosphoinositide interacting 2",TRUE
+"1570033_at",0.901978467243536,0.600345564396113,0.531522674023042,-5.80300913385008,0.174914803119262,"WIPI2","WD repeat domain, phosphoinositide interacting 2",TRUE
+"235821_at",0.784789297644843,0.309362761649596,1.04042608118917,-5.42576453061297,0.862216549725301,"WISP1","WNT1 inducible signaling pathway protein 1",TRUE
+"211312_s_at",0.823074246722209,0.389343910140449,0.878040804994108,-5.57099774710123,0.497929642666847,"WISP1","WNT1 inducible signaling pathway protein 1",TRUE
+"206796_at",0.921071391932863,0.663963178239596,-0.440331103795754,-5.84568479804231,-0.32273776857757,"WISP1","WNT1 inducible signaling pathway protein 1",TRUE
+"229802_at",0.975398143273847,0.881669877604097,-0.15057950926871,-5.92864575006056,-0.150428204825831,"WISP1","WNT1 inducible signaling pathway protein 1",TRUE
+"205792_at",0.88698237223329,0.551022369841048,0.605464656329578,-5.76269241783166,0.680721107908615,"WISP2","WNT1 inducible signaling pathway protein 2",TRUE
+"210861_s_at",0.81836001261482,0.371585886140609,0.911999057907476,-5.54249426482423,1.07461790808585,"WISP3","WNT1 inducible signaling pathway protein 3",TRUE
+"226182_s_at",0.923494952314901,0.671807740893879,0.429359740249187,-5.85029020254246,0.284792532304631,"WISP3","WNT1 inducible signaling pathway protein 3",TRUE
+"221783_at",0.714795139167042,0.190394463062354,-1.35079993265033,-5.08800909303355,-0.7095501732459,"WIZ","widely interspaced zinc finger motifs",TRUE
+"221784_at",0.896428361916712,0.580875628863127,-0.56033120445361,-5.78790599855336,-0.338726327956222,"WIZ","widely interspaced zinc finger motifs",TRUE
+"221785_at",0.953564723226096,0.786049459180692,0.274755893715276,-5.90298143589833,0.146930240797778,"WIZ","widely interspaced zinc finger motifs",TRUE
+"52005_at",0.976589025744684,0.888618357053153,0.141673289369069,-5.92991220623055,0.0490257326727335,"WIZ","widely interspaced zinc finger motifs",TRUE
+"228949_at",0.775351898377291,0.292135318446971,1.07913549575834,-5.38786157326024,1.62627358625783,"WLS","wntless Wnt ligand secretion mediator",TRUE
+"228950_s_at",0.789068917276932,0.315310063185485,1.02741800379223,-5.43822202226257,1.18079681955025,"WLS","wntless Wnt ligand secretion mediator",TRUE
+"221958_s_at",0.841391443291102,0.431881585225532,0.800570041920122,-5.63224889015425,0.917336393538806,"WLS","wntless Wnt ligand secretion mediator",TRUE
+"228712_at",0.792243446641505,0.323101410837427,-1.01063458107479,-5.45408584578068,-0.788799336383254,"WNK1","WNK lysine deficient protein kinase 1",TRUE
+"1555068_at",0.797127506889432,0.330274535662714,-0.995430481023429,-5.46825248376161,-0.378676373260604,"WNK1","WNK lysine deficient protein kinase 1",TRUE
+"211994_at",0.802994404953081,0.340657617245299,-0.97382172116964,-5.48805070646229,-0.433574774478421,"WNK1","WNK lysine deficient protein kinase 1",TRUE
+"39313_at",0.822010986888098,0.385650625736853,-0.885018451753226,-5.56522268656484,-0.34530696310887,"WNK1","WNK lysine deficient protein kinase 1",TRUE
+"211992_at",0.845738161733126,0.443723984391695,-0.779861199498978,-5.64772327862371,-0.366489274141113,"WNK1","WNK lysine deficient protein kinase 1",TRUE
+"202940_at",0.875990189898743,0.524505317768994,0.646643545294228,-5.73804585968115,0.201936279504366,"WNK1","WNK lysine deficient protein kinase 1",TRUE
+"211993_at",0.943512938262733,0.747570355950338,-0.325883441515209,-5.88808933093103,-0.189574815445474,"WNK1","WNK lysine deficient protein kinase 1",TRUE
+"1557536_at",0.622917527985155,0.0938896801550703,-1.75037943098049,-4.54834279223823,-0.532864082916323,"WNK2","WNK lysine deficient protein kinase 2",TRUE
+"1562026_at",0.739007386198624,0.22566043370264,1.24632877200843,-5.21016993185637,0.429527903884596,"WNK2","WNK lysine deficient protein kinase 2",TRUE
+"229547_s_at",0.774230543658252,0.286227261932695,1.09278649962977,-5.37419989219749,0.611375476224353,"WNK2","WNK lysine deficient protein kinase 2",TRUE
+"227217_at",0.797127506889432,0.330339552832204,0.995293723257712,-5.46837902529667,0.534742409593857,"WNK2","WNK lysine deficient protein kinase 2",TRUE
+"239670_at",0.876039291047695,0.524646191971938,0.646421842381912,-5.73818272830346,0.297157904220781,"WNK2","WNK lysine deficient protein kinase 2",TRUE
+"1560866_at",0.919832926184047,0.658931801003211,-0.447396892750773,-5.84265845133929,-0.21032816880668,"WNK2","WNK lysine deficient protein kinase 2",TRUE
+"1555248_a_at",0.863719378931144,0.489168377311536,-0.70334168979622,-5.70156871374438,-0.230506399858462,"WNK3","WNK lysine deficient protein kinase 3",TRUE
+"236236_at",0.865345395265289,0.494987352607966,0.693849591644898,-5.7078796143792,0.563271362598842,"WNK3","WNK lysine deficient protein kinase 3",TRUE
+"232282_at",0.927751423245943,0.68287878943598,-0.41396611189949,-5.85655940955717,-0.342188505712277,"WNK3","WNK lysine deficient protein kinase 3",TRUE
+"244344_at",0.918400220203619,0.653470942232856,-0.455092106989685,-5.83930876945678,-0.308110323435768,"WNK4","WNK lysine deficient protein kinase 4",TRUE
+"229158_at",0.966773610653397,0.845556254024497,0.197086930316992,-5.92078205138919,0.22030614558241,"WNK4","WNK lysine deficient protein kinase 4",TRUE
+"208570_at",0.955904644595647,0.800244796532557,-0.256088952371906,-5.90779150960183,-0.1727605099298,"WNT1","Wnt family member 1",TRUE
+"223709_s_at",0.000138066450792401,7.57566259491912e-09,8.9909332795762,9.28688126858084,5.39401611429295,"WNT10A","Wnt family member 10A",TRUE
+"229154_at",0.696146909796005,0.166222183948548,1.43157170704478,-4.98794165312012,1.04022426585885,"WNT10A","Wnt family member 10A",TRUE
+"206213_at",0.983777183253528,0.920620406401698,-0.100794140899315,-5.93473639408378,-0.0847857617508296,"WNT10B","Wnt family member 10B",TRUE
+"206737_at",0.643852971767472,0.114768926618121,1.64171243008124,-4.70584178369131,2.06333714713901,"WNT11","Wnt family member 11",TRUE
+"224022_x_at",0.308861881799719,0.00639726749774517,3.01088681016116,-2.28591201509178,3.52437031734639,"WNT16","Wnt family member 16",TRUE
+"221113_s_at",0.597346378847428,0.0732677546276277,1.88037559231759,-4.35025380505891,0.834114322185175,"WNT16","Wnt family member 16",TRUE
+"205648_at",0.953768355485382,0.786669186263718,0.273938913368283,-5.90319898369981,0.180601929414165,"WNT2","Wnt family member 2",TRUE
+"206459_s_at",0.73759219552868,0.2241496520371,1.2505359453335,-5.20541245243222,0.71292472999188,"WNT2B","Wnt family member 2B",TRUE
+"206458_s_at",0.753862100951903,0.247178481452454,1.18860673148936,-5.27404147919909,0.997321891779515,"WNT2B","Wnt family member 2B",TRUE
+"236123_at",0.792212765896181,0.323003670299861,1.01084336417402,-5.45388995453717,0.443937140994069,"WNT2B","Wnt family member 2B",TRUE
+"238512_at",0.904927159573989,0.610451365826565,0.516748764937187,-5.81045364202954,0.496372955001906,"WNT2B","Wnt family member 2B",TRUE
+"208606_s_at",0.927973182663162,0.683880015459867,-0.412579025884478,-5.8571132605531,-0.618812328677981,"WNT4","Wnt family member 4",TRUE
+"1556689_a_at",0.929234395612144,0.688926454489945,-0.405600201967226,-5.85987209039545,-0.257872357722534,"WNT4","Wnt family member 4",TRUE
+"230751_at",0.980009054680439,0.905903531816701,0.119567198378583,-5.93272267087707,0.105051869447646,"WNT4","Wnt family member 4",TRUE
+"205990_s_at",0.941345931827527,0.737719076121552,0.339111062185988,-5.88382770468676,0.417202959406664,"WNT5A","Wnt family member 5A",TRUE
+"213425_at",0.954456115752166,0.791408651259706,0.267697170006294,-5.9048398216308,0.346664315636975,"WNT5A","Wnt family member 5A",TRUE
+"223537_s_at",0.536422380101288,0.0432611414490824,2.14394670998213,-3.91904842409193,1.90977792902564,"WNT5B","Wnt family member 5B",TRUE
+"221029_s_at",0.700061364939874,0.171800293407425,1.41213992374753,-5.01245350509631,2.16685815062727,"WNT5B","Wnt family member 5B",TRUE
+"230299_s_at",0.990623482682449,0.952562323448314,0.0601666303833023,-5.93792045461813,0.0428932256751366,"WNT5B","Wnt family member 5B",TRUE
+"222086_s_at",0.498206796273596,0.0310694795138618,2.30251616965493,-3.64251395854959,0.69263375495241,"WNT6","Wnt family member 6",TRUE
+"71933_at",0.768882610729436,0.274240029872586,1.12112295438868,-5.34535420857931,0.324369365714039,"WNT6","Wnt family member 6",TRUE
+"221609_s_at",0.769258076576208,0.276412396600623,1.11592182831047,-5.35069787171407,1.02719985114234,"WNT6","Wnt family member 6",TRUE
+"221608_at",0.848364007856994,0.448357597803712,0.771850551924567,-5.65360658336872,0.58512968431146,"WNT6","Wnt family member 6",TRUE
+"210248_at",0.442846733327149,0.0206158111815121,2.49307998105184,-3.29531882471209,1.62519179892277,"WNT7A","Wnt family member 7A",TRUE
+"217681_at",0.822010986888098,0.385677670245773,0.884967199094888,-5.56526526042853,0.623694685294288,"WNT7B","Wnt family member 7B",TRUE
+"238105_x_at",0.841372027765592,0.431798813812584,0.800716008775317,-5.63213846470558,0.737891304821144,"WNT7B","Wnt family member 7B",TRUE
+"224259_at",0.947062793209778,0.759780764615074,0.309569776866748,-5.89311403344512,0.14451399711861,"WNT8A","Wnt family member 8A",TRUE
+"207612_at",0.931370027472813,0.696533839150561,-0.39511826574375,-5.86392869027341,-0.190472536725197,"WNT8B","Wnt family member 8B",TRUE
+"230643_at",0.690823350461169,0.16050350289727,1.45204507466919,-4.96181980701685,0.853592076956547,"WNT9A","Wnt family member 9A",TRUE
+"1553045_at",0.710739561811938,0.183962428702031,1.37145865096847,-5.06287400528856,1.39805302474082,"WNT9A","Wnt family member 9A",TRUE
+"1552973_at",0.871744769522775,0.514321807513645,-0.662757673363685,-5.72797719896711,-0.282164554729089,"WNT9B","Wnt family member 9B",TRUE
+"44563_at",0.834265235157814,0.412257206200427,0.835678640980043,-5.60514532407288,0.301601093615266,"WRAP53","WD repeat containing antisense to TP53",TRUE
+"220258_s_at",0.873688059772933,0.519339038731053,0.654796748861268,-5.73298117401882,0.244241312633291,"WRAP53","WD repeat containing antisense to TP53",TRUE
+"236381_s_at",0.805127581292656,0.344301563387354,0.966345342653007,-5.49480841226987,0.33629113472116,"WRAP73","WD repeat containing, antisense to TP73",TRUE
+"219322_s_at",0.909253954288789,0.623331627154136,0.498085670766236,-5.81956539607331,0.177010347529066,"WRAP73","WD repeat containing, antisense to TP73",TRUE
+"236382_at",0.980264692225439,0.907582298864729,0.117423643370937,-5.93296993300213,0.100188403486412,"WRAP73","WD repeat containing, antisense to TP73",TRUE
+"202749_at",0.526253358601247,0.039551604364428,-2.1873638012816,-3.84452867660974,-0.739950968563607,"WRB","tryptophan rich basic protein",TRUE
+"205667_at",0.977874971442423,0.893056787548862,-0.135990508803623,-5.93068003068059,-0.0516055555749855,"WRN","Werner syndrome RecQ like helicase",TRUE
+"222489_s_at",0.523369751179323,0.038883432354842,2.19557388867085,-3.83033329014735,0.77831624034026,"WRNIP1","Werner helicase interacting protein 1",TRUE
+"230847_at",0.623667408398064,0.0947138665248262,1.74571682552374,-4.55525534789491,0.939495262740764,"WRNIP1","Werner helicase interacting protein 1",TRUE
+"218015_s_at",0.635916735157933,0.107116710510579,1.67942834785441,-4.65204040845199,0.857640139087494,"WRNIP1","Werner helicase interacting protein 1",TRUE
+"227619_at",0.976422537443518,0.888021597321652,-0.142437715806233,-5.92980652769816,-0.0864331250431096,"WRNIP1","Werner helicase interacting protein 1",TRUE
+"213406_at",0.67818193964437,0.145572423347639,1.5084307412646,-4.88832790315137,0.494916714296036,"WSB1","WD repeat and SOCS box containing 1",TRUE
+"201294_s_at",0.716749536957327,0.192763954019065,1.34332801401784,-5.09702147577218,0.661852503001496,"WSB1","WD repeat and SOCS box containing 1",TRUE
+"201295_s_at",0.745633950719346,0.237307295408639,1.21459421219248,-5.24560988677291,0.89364365549042,"WSB1","WD repeat and SOCS box containing 1",TRUE
+"210561_s_at",0.798932955106764,0.333411124584747,0.988854037172388,-5.47431975540816,0.362218935234068,"WSB1","WD repeat and SOCS box containing 1",TRUE
+"201296_s_at",0.862800800218883,0.486780064377364,0.707256363853154,-5.69894220075129,0.239273660005694,"WSB1","WD repeat and SOCS box containing 1",TRUE
+"201760_s_at",0.895366192695711,0.573636879036703,-0.571164062653183,-5.7820266982762,-0.198793078496193,"WSB2","WD repeat and SOCS box containing 2",TRUE
+"207637_at",0.73957587762701,0.228163685342055,1.23940485133066,-5.21796949723137,0.448687629128802,"WSCD2","WSC domain containing 2",TRUE
+"229032_at",0.940227139261806,0.732893586261217,0.345612829472595,-5.88167152735508,0.223873447561001,"WSCD2","WSC domain containing 2",TRUE
+"216953_s_at",0.985361089461736,0.927427312731634,0.0921241058867894,-5.9355506938206,0.108692749877747,"WT1","Wilms tumor 1",TRUE
+"206067_s_at",0.988802593747325,0.946230279057226,-0.0682100115232253,-5.93741762211901,-0.127257795236614,"WT1","Wilms tumor 1",TRUE
+"206954_at",0.867099100798202,0.498974965240933,0.68738165192696,-5.71213298529399,0.463805219602455,"WT1-AS","WT1 antisense RNA",TRUE
+"214759_at",0.667209925683767,0.13371769503637,1.55667300903135,-4.82367690959524,0.464333432393536,"WTAP","Wilms tumor 1 associated protein",TRUE
+"1560274_at",0.695812999227098,0.166002464781313,1.4323477647416,-4.98695701066458,1.20444467909277,"WTAP","Wilms tumor 1 associated protein",TRUE
+"241626_at",0.772430642757484,0.282896484445184,-1.10057232459525,-5.36633950329135,-0.468497755406186,"WTAP","Wilms tumor 1 associated protein",TRUE
+"210285_x_at",0.784552021081681,0.308106552909364,1.04319620730388,-5.42309342435498,0.363423254995379,"WTAP","Wilms tumor 1 associated protein",TRUE
+"203137_at",0.790361168948463,0.320083890901909,1.01710071495423,-5.44800198380802,0.331098382986799,"WTAP","Wilms tumor 1 associated protein",TRUE
+"229630_s_at",0.807084045192774,0.348376295612923,0.958048749473851,-5.5022517800412,0.312053877469284,"WTAP","Wilms tumor 1 associated protein",TRUE
+"227621_at",0.849935057946582,0.452393241226266,-0.764914536669147,-5.65865431078327,-0.285561769441255,"WTAP","Wilms tumor 1 associated protein",TRUE
+"201047_x_at",0.90343137006939,0.603664374711366,-0.526657770899602,-5.80548310023109,-0.212146833373673,"WTH3DI///RAB6A","RAB6C-like///RAB6A, member RAS oncogene family",TRUE
+"201048_x_at",0.959623505183049,0.817716940492726,-0.233239237821387,-5.91322166311701,-0.133954310877311,"WTH3DI///RAB6A","RAB6C-like///RAB6A, member RAS oncogene family",TRUE
+"201045_s_at",0.966593471043185,0.844455951262773,-0.198510379907454,-5.92050829619234,-0.127066788305608,"WTH3DI///RAB6A","RAB6C-like///RAB6A, member RAS oncogene family",TRUE
+"210406_s_at",0.88587213211399,0.547854510562734,-0.610327593908037,-5.75986319060274,-0.22639800264959,"WTH3DI///RAB6C///RAB6A","RAB6C-like///RAB6C, member RAS oncogene family///RAB6A, member RAS oncogene family",TRUE
+"227411_at",0.735226171133396,0.22022494750163,-1.26156755642492,-5.19287258621244,-1.20674982078388,"WTIP","Wilms tumor 1 interacting protein",TRUE
+"243290_at",0.594005743610726,0.0708418755668711,1.89770197475531,-4.32309042207023,0.701412726295235,"WWC1","WW and C2 domain containing 1",TRUE
+"236725_at",0.756006545489432,0.250829456948189,1.1791920726826,-5.28420941209773,0.552750393379384,"WWC1","WW and C2 domain containing 1",TRUE
+"241950_at",0.757950630724418,0.254320271714279,1.17028554024788,-5.29376352657562,0.598546410839431,"WWC1","WW and C2 domain containing 1",TRUE
+"1554511_at",0.819250502714397,0.376173165288717,-0.90312641258381,-5.55003818893482,-0.566707717157416,"WWC1","WW and C2 domain containing 1",TRUE
+"237238_at",0.859675188316647,0.477806935669212,0.722064471564092,-5.68888130817252,0.500767889610312,"WWC1","WW and C2 domain containing 1",TRUE
+"229180_at",0.923392984964514,0.671247705434565,0.430141213774836,-5.84996594132523,0.297528744263224,"WWC1","WW and C2 domain containing 1",TRUE
+"216074_x_at",0.937462538530338,0.722643514664853,-0.359474525099811,-5.87693948380348,-0.304153783372572,"WWC1","WW and C2 domain containing 1",TRUE
+"213085_s_at",0.969259513938963,0.854118397468299,0.186024161206782,-5.92284270833733,0.0851514583384869,"WWC1","WW and C2 domain containing 1",TRUE
+"237656_at",0.978995847749076,0.898365765865615,-0.129199116956966,-5.93155649138022,-0.076254727900988,"WWC2","WW and C2 domain containing 2",TRUE
+"230572_at",0.930065981387326,0.691332791305941,-0.402279652974616,-5.86116848770565,-0.119765523179054,"WWC2-AS2","WWC2 antisense RNA 2",TRUE
+"1554762_a_at",0.816176177026814,0.367133733841746,0.920680052679228,-5.5350474630275,0.423119250483531,"WWC2///CLDN22","WW and C2 domain containing 2///claudin 22",TRUE
+"218775_s_at",0.84571977676742,0.443575802164452,0.780118217997751,-5.64753356654899,0.594734629559808,"WWC2///CLDN22","WW and C2 domain containing 2///claudin 22",TRUE
+"222738_at",0.913221029035633,0.63596041132414,0.479959472719275,-5.82810167390323,0.292153436976024,"WWC2///CLDN22","WW and C2 domain containing 2///claudin 22",TRUE
+"225273_at",0.661121988136487,0.128833302362406,-1.57758210359056,-4.79515734816671,-0.8990273361939,"WWC3","WWC family member 3",TRUE
+"219520_s_at",0.679582597949812,0.146872391912351,-1.50333894835602,-4.89505689246339,-0.887725538415435,"WWC3","WWC family member 3",TRUE
+"219077_s_at",0.615821255316333,0.0865798493897742,-1.79334664648307,-4.48400520156017,-1.19174700872439,"WWOX","WW domain containing oxidoreductase",TRUE
+"210695_s_at",0.685154158710982,0.153671961764041,-1.47728994602341,-4.92919548613551,-0.626863510219682,"WWOX","WW domain containing oxidoreductase",TRUE
+"223868_s_at",0.699161781955613,0.1705566424564,-1.41642800365148,-5.00706803948374,-0.802871332923882,"WWOX","WW domain containing oxidoreductase",TRUE
+"221147_x_at",0.812896635201594,0.361920910296212,-0.93093384675722,-5.52616780281817,-0.61968926543905,"WWOX","WW domain containing oxidoreductase",TRUE
+"223747_x_at",0.931121627074226,0.694959463722875,-0.397283806972184,-5.86309917901196,-0.297614071524149,"WWOX","WW domain containing oxidoreductase",TRUE
+"212637_s_at",0.577973495635987,0.0616187929778174,-1.96872661641742,-4.2099433618828,-0.910880144146789,"WWP1","WW domain containing E3 ubiquitin protein ligase 1",TRUE
+"212638_s_at",0.615821255316333,0.0868764294064905,-1.79154363603377,-4.48672786676414,-0.797693001918596,"WWP1","WW domain containing E3 ubiquitin protein ligase 1",TRUE
+"1554580_a_at",0.528412182286162,0.0410618508781113,2.16926046429398,-3.87571359515534,0.9090485183097,"WWP2","WW domain containing E3 ubiquitin protein ligase 2",TRUE
+"1552737_s_at",0.776063130338123,0.293434898829081,-1.0761594020882,-5.3908196415604,-0.350553453958364,"WWP2","WW domain containing E3 ubiquitin protein ligase 2",TRUE
+"210200_at",0.931200671428958,0.695177280397179,-0.396984086790415,-5.86321425318327,-0.135295271974961,"WWP2","WW domain containing E3 ubiquitin protein ligase 2",TRUE
+"204022_at",0.946050828306305,0.755728091917237,-0.314974613045316,-5.89147761659584,-0.107445696769426,"WWP2","WW domain containing E3 ubiquitin protein ligase 2",TRUE
+"202132_at",0.630273042704438,0.101382647395981,1.70921462467078,-4.60889776008784,1.20662238631542,"WWTR1","WW domain containing transcription regulator 1",TRUE
+"202133_at",0.695439932196858,0.164904814478879,1.43623712757561,-4.98201571245395,1.40738192138643,"WWTR1","WW domain containing transcription regulator 1",TRUE
+"202134_s_at",0.737123149977386,0.223083770129196,1.25351722770707,-5.20203288014658,1.12478176666237,"WWTR1","WW domain containing transcription regulator 1",TRUE
+"228629_s_at",0.877488742289724,0.527422284417126,0.642059547545204,-5.74086662585482,0.274665479397603,"WWTR1-AS1","WWTR1 antisense RNA 1",TRUE
+"1562765_at",0.900867933475689,0.596744369178285,0.536816244345098,-5.80029203228952,0.196327008717318,"WWTR1-AS1","WWTR1 antisense RNA 1",TRUE
+"218110_at",0.784918343662568,0.309760640341552,1.03955035703637,-5.42660762142897,0.350392061453467,"XAB2","XPA binding protein 2",TRUE
+"228617_at",0.433660982257499,0.019525441975177,2.51790217237168,-3.24900282218696,2.65264676154561,"XAF1","XIAP associated factor 1",TRUE
+"206133_at",0.496922175347448,0.0304106373792878,2.31262578528454,-3.62448649445016,1.77911316588155,"XAF1","XIAP associated factor 1",TRUE
+"242234_at",0.517654151778308,0.0367951086880437,2.22208643140065,-3.78427088781655,0.881638351507134,"XAF1","XIAP associated factor 1",TRUE
+"1565454_at",0.822173415758858,0.386451567864115,0.883501561258577,-5.56648174935816,0.220213960538452,"XAGE-4","XAGE-4 protein",TRUE
+"220057_at",0.662855903464759,0.13087388162601,1.56876824997324,-4.80721568990833,2.54841518232812,"XAGE1B///XAGE1E","X antigen family member 1B///X antigen family member 1E",TRUE
+"229469_at",0.501591596209182,0.0322818468943969,-2.28441586826248,-3.67467530010828,-0.866231845915086,"XAGE2","X antigen family member 2",TRUE
+"236040_at",0.986455005400648,0.936877175090708,0.0800995430665653,-5.93655899757852,0.0550608940095696,"XAGE3","X antigen family member 3",TRUE
+"200670_at",0.446229200741107,0.0209100667827014,-2.48659093745599,-3.30738721674452,-1.81898426331105,"XBP1","X-box binding protein 1",TRUE
+"242021_at",0.812302873476553,0.356760487926232,0.941182465373671,-5.51720231124511,0.645809054155297,"XBP1","X-box binding protein 1",TRUE
+"206366_x_at",0.45016808873778,0.021522439578611,2.47335473030729,-3.33195260154495,1.54548191455646,"XCL1","X-C motif chemokine ligand 1",TRUE
+"206365_at",0.791838559691106,0.322644342620914,1.01161130101865,-5.45316912070642,0.815684982127157,"XCL1","X-C motif chemokine ligand 1",TRUE
+"214567_s_at",0.604682600348682,0.0787563538732528,1.84295182083067,-4.40832380973042,0.91794121845657,"XCL2///XCL1","X-C motif chemokine ligand 2///X-C motif chemokine ligand 1",TRUE
+"1561226_at",0.853460708803218,0.462138385757213,0.748317942916096,-5.67055763969669,0.381417307100041,"XCR1","X-C motif chemokine receptor 1",TRUE
+"221468_at",0.908619002315341,0.619745914324266,0.503262991049835,-5.81707048018344,0.379294447909746,"XCR1","X-C motif chemokine receptor 1",TRUE
+"241994_at",0.194325783329824,0.00207093078563955,3.48722427896666,-1.29788479527451,2.27531713827707,"XDH","xanthine dehydrogenase",TRUE
+"210301_at",0.559434208511607,0.0539784437044003,2.03508236984852,-4.10169704281629,0.92852193291168,"XDH","xanthine dehydrogenase",TRUE
+"1554062_at",0.369623435296638,0.0111005337129781,2.7709663110357,-2.76409432081417,2.90858139228672,"XG","Xg blood group",TRUE
+"241931_at",0.790854069129,0.32078227144168,1.0156004086757,-5.44941672153035,0.645594710051719,"XG","Xg blood group",TRUE
+"1563420_at",0.686108994812404,0.154523782360677,1.47409312465343,-4.93335195099079,1.03814291885583,"XGY2///XG","Xg pseudogene, Y-linked 2///Xg blood group",TRUE
+"225858_s_at",0.758722841981575,0.255892016018051,-1.1663050384313,-5.29801294889705,-0.422081671543731,"XIAP","X-linked inhibitor of apoptosis",TRUE
+"228363_at",0.796327569283512,0.328617874422579,-0.998921423482818,-5.4650169806043,-0.325828325003229,"XIAP","X-linked inhibitor of apoptosis",TRUE
+"235222_x_at",0.819018525257656,0.374869510313986,-0.905640612683297,-5.54790741738359,-0.337006443933806,"XIAP","X-linked inhibitor of apoptosis",TRUE
+"225859_at",0.869431261690674,0.506472531958811,-0.675299440391101,-5.71997634622653,-0.248748099749799,"XIAP","X-linked inhibitor of apoptosis",TRUE
+"206536_s_at",0.896229101808264,0.579595638750009,-0.562241760601584,-5.78687701448833,-0.193667133564071,"XIAP","X-linked inhibitor of apoptosis",TRUE
+"243026_x_at",0.940044918888428,0.730950879543316,-0.348234671273996,-5.88079059456051,-0.114678416473929,"XIAP","X-linked inhibitor of apoptosis",TRUE
+"206537_at",0.992869169400525,0.966338179798437,-0.0426809318634788,-5.9387962553293,-0.0109325160023817,"XIAP","X-linked inhibitor of apoptosis",TRUE
+"235042_at",0.953983577550391,0.788479141242866,0.271553954560116,-5.9038303776974,0.141084442035861,"XIRP1","xin actin binding repeat containing 1",TRUE
+"228794_at",0.795415493257984,0.327530534563947,1.00121931617884,-5.46288161829125,0.822146843326366,"XIRP2","xin actin binding repeat containing 2",TRUE
+"235446_at",0.868397087637799,0.503340246383563,0.680334698248504,-5.71672379106791,0.44525602961993,"XIST","X inactive specific transcript (non-protein coding)",TRUE
+"243712_at",0.920147736488699,0.65997853372267,0.445925023801081,-5.84329276457887,0.319302853182687,"XIST","X inactive specific transcript (non-protein coding)",TRUE
+"221728_x_at",0.932091525948902,0.69978666632407,-0.390650097287849,-5.86562610768485,-0.663726529332645,"XIST","X inactive specific transcript (non-protein coding)",TRUE
+"224590_at",0.942502815705589,0.742258226095878,-0.333008683229522,-5.88581458857802,-0.770405410700663,"XIST","X inactive specific transcript (non-protein coding)",TRUE
+"227671_at",0.95168059103032,0.778430774591964,-0.284815347478615,-5.90025007789887,-0.51098407706021,"XIST","X inactive specific transcript (non-protein coding)",TRUE
+"214218_s_at",0.960052378587415,0.819262255651633,-0.231224583954575,-5.91367624270161,-0.362004623101754,"XIST","X inactive specific transcript (non-protein coding)",TRUE
+"224588_at",0.991059530537351,0.958318408629788,-0.0528584127512514,-5.93832271224063,-0.136647005374909,"XIST","X inactive specific transcript (non-protein coding)",TRUE
+"224589_at",0.996898592071515,0.984117616362197,0.0201328313078322,-5.9394860609422,0.0387290877606246,"XIST","X inactive specific transcript (non-protein coding)",TRUE
+"206698_at",0.60998004334651,0.0821418264308832,1.82098483864801,-4.44202168313041,1.90516095394146,"XK","X-linked Kx blood group",TRUE
+"237802_at",0.901788521024914,0.599513239712028,0.532744777732881,-5.80238417415397,0.380413953570198,"XKR4","XK related 4",TRUE
+"1553640_at",0.612420348961838,0.0842173141512773,-1.80790287796492,-4.46195157985032,-0.920471398074064,"XKR6","XK related 6",TRUE
+"243260_x_at",0.830635993561085,0.404507554432088,0.849833279636724,-5.5939104745547,0.587289941642219,"XKR6","XK related 6",TRUE
+"236047_at",0.948764595648089,0.766959261059977,-0.300019129160606,-5.89593705279301,-0.270406882981736,"XKR6","XK related 6",TRUE
+"1557436_at",0.988713664405312,0.945487591122232,0.0691537145315307,-5.93735449820493,0.0386886697106323,"XKR6","XK related 6",TRUE
+"243101_x_at",0.886023097762234,0.548649008247817,-0.609106581370441,-5.7605756213699,-0.264849262846235,"XKR7","XK related 7",TRUE
+"218753_at",0.971282250892504,0.863773900673991,0.17357707437929,-5.92501940088803,0.0532376064967135,"XKR8","XK related 8",TRUE
+"230349_at",0.936143408699214,0.715030365389817,0.369816674356587,-5.87328924760205,0.214366183237252,"XKRX","XK related, X-linked",TRUE
+"208339_at",0.97589003385521,0.88462099207471,-0.14679543475055,-5.92919325327596,-0.110498847562315,"XKRY2///XKRY","XK related, Y-linked 2///XK related, Y-linked",TRUE
+"205672_at",0.973493137611142,0.872229340341891,0.162700084546793,-5.92679849658083,0.0491918134901166,"XPA","XPA, DNA damage recognition and repair factor",TRUE
+"209375_at",0.936495018406481,0.716613502997269,-0.367662698673725,-5.87405791400908,-0.150800466031027,"XPC","XPC complex subunit, DNA damage recognition and repair factor",TRUE
+"236239_at",0.627053909308516,0.0977888116392834,1.72862202394622,-4.58048233495014,0.528106264954815,"XPNPEP1","X-prolyl aminopeptidase 1",TRUE
+"208453_s_at",0.826140850652187,0.39409619438048,0.869125425867152,-5.57831481807005,0.343218098893628,"XPNPEP1","X-prolyl aminopeptidase 1",TRUE
+"209045_at",0.92051722798026,0.662123213984439,0.442912388375926,-5.84458468864256,0.152068081341152,"XPNPEP1","X-prolyl aminopeptidase 1",TRUE
+"206484_s_at",0.74126098489332,0.231935318400898,1.22908098957112,-5.22952945405801,0.69148414181182,"XPNPEP2","X-prolyl aminopeptidase 2",TRUE
+"216910_at",0.989524702314661,0.948939186142795,0.0647684460442274,-5.93764048102351,0.0445406814550937,"XPNPEP2","X-prolyl aminopeptidase 2",TRUE
+"227910_at",0.724590981430178,0.201768460060446,-1.31557387634526,-5.13012952096077,-1.30044836888005,"XPNPEP3","X-prolyl aminopeptidase 3",TRUE
+"237750_at",0.926209999527899,0.679542531706669,0.418594108202936,-5.85469826680464,0.419397995251727,"XPNPEP3","X-prolyl aminopeptidase 3",TRUE
+"220020_at",0.942373096422033,0.74108533560776,-0.334584258591839,-5.88530501213304,-0.160362380660441,"XPNPEP3","X-prolyl aminopeptidase 3",TRUE
+"226501_at",0.948200794831469,0.764526453394613,0.303252628964803,-5.89499109847028,0.0941835154417436,"XPNPEP3","X-prolyl aminopeptidase 3",TRUE
+"228820_at",0.972278576610345,0.866540907162427,0.170015331355494,-5.92561461594802,0.107934154016799,"XPNPEP3","X-prolyl aminopeptidase 3",TRUE
+"224188_s_at",0.995025131654789,0.976734024682598,-0.0294948084024044,-5.93925977211921,-0.0211411956368144,"XPNPEP3","X-prolyl aminopeptidase 3",TRUE
+"235927_at",0.695439932196858,0.164934057627739,1.43613323918248,-4.98214784134948,0.669891347323148,"XPO1","exportin 1",TRUE
+"208775_at",0.872505590628774,0.515710218455477,0.660550368533039,-5.72937044736996,0.158611884354821,"XPO1","exportin 1",TRUE
+"244012_x_at",0.950980582261399,0.776176088615857,-0.287798075468915,-5.89942147302494,-0.144294490630436,"XPO1","exportin 1",TRUE
+"218479_s_at",0.969882914559333,0.856721009223927,-0.182666208377253,-5.92344472808636,-0.0691214125372319,"XPO4","exportin 4",TRUE
+"222649_at",0.979588787486838,0.901841864275069,-0.124755785115607,-5.93210566936,-0.0479964540678655,"XPO4","exportin 4",TRUE
+"223057_s_at",0.921312278448293,0.664588422987937,-0.439454640771498,-5.84605689981004,-0.136135053119787,"XPO5","exportin 5",TRUE
+"223056_s_at",0.955892698633978,0.799464716477843,-0.257112289332846,-5.90753652424119,-0.0885624193620114,"XPO5","exportin 5",TRUE
+"223055_s_at",0.97888153352884,0.896923264887693,0.131043774737592,-5.93132286298444,0.0519490666347924,"XPO5","exportin 5",TRUE
+"214784_x_at",0.786438645528911,0.311890877536097,-1.03487519250764,-5.43109774896369,-0.233741681180232,"XPO6","exportin 6",TRUE
+"211982_x_at",0.94333312187812,0.745671501811697,-0.328428408672617,-5.88728243630023,-0.0914876882735687,"XPO6","exportin 6",TRUE
+"240168_at",0.80861715520522,0.351784443615589,0.951159883732732,-5.50838756482027,0.377511936480203,"XPO7","exportin 7",TRUE
+"208459_s_at",0.892746695408886,0.565453499567791,0.58349435503294,-5.77520200344032,0.166050473458295,"XPO7","exportin 7",TRUE
+"212166_at",0.901788521024914,0.599499842649803,-0.53276445537242,-5.8023740999737,-0.152511768700981,"XPO7","exportin 7",TRUE
+"212160_at",0.737535792093258,0.223894543886308,-1.25124849745655,-5.2046053337786,-0.357371152620782,"XPOT","exportin for tRNA",TRUE
+"227117_at",0.752913428584105,0.246112728689152,-1.19137455445153,-5.27103879367423,-0.57832596274206,"XPOT","exportin for tRNA",TRUE
+"222581_at",0.812302873476553,0.358455161727822,-0.937805918010559,-5.52016607295372,-0.475604986669426,"XPR1","xenotropic and polytropic retrovirus receptor 1",TRUE
+"226615_at",0.824475333086881,0.391872711128098,-0.873287993827158,-5.57490712751171,-0.419180449582716,"XPR1","xenotropic and polytropic retrovirus receptor 1",TRUE
+"244755_at",0.957283234301336,0.806596149453636,0.247767306217745,-5.90982749208991,0.15046681872632,"XPR1","xenotropic and polytropic retrovirus receptor 1",TRUE
+"203655_at",0.68033297785336,0.14788523826914,-1.49939723999911,-4.90025348433337,-0.617662785158746,"XRCC1","X-ray repair cross complementing 1",TRUE
+"207598_x_at",0.838606419538945,0.423697553421926,0.815087512474378,-5.62117373666833,0.251897104623575,"XRCC2","X-ray repair cross complementing 2",TRUE
+"216299_s_at",0.941106542715586,0.735997839892395,-0.341428496661254,-5.88306381903777,-0.127462447246325,"XRCC3","X-ray repair cross complementing 3",TRUE
+"205071_x_at",0.83083080573017,0.404670084933114,0.849534653115199,-5.59414931903183,0.364949870592918,"XRCC4","X-ray repair cross complementing 4",TRUE
+"210812_at",0.851814807653424,0.456902344824177,-0.757208841922882,-5.66421167267695,-0.389028969659391,"XRCC4","X-ray repair cross complementing 4",TRUE
+"205072_s_at",0.872010957446544,0.514710503914267,0.662139388118128,-5.7283679091328,0.262761507593444,"XRCC4","X-ray repair cross complementing 4",TRUE
+"210813_s_at",0.9802233499944,0.907032569302472,0.118125509985078,-5.93288946353641,0.0412334814513908,"XRCC4","X-ray repair cross complementing 4",TRUE
+"208643_s_at",0.62110896023334,0.0916295605242497,-1.76334788302515,-4.5290449140434,-0.535634597390624,"XRCC5","X-ray repair cross complementing 5",TRUE
+"208642_s_at",0.677013732819214,0.144333773933406,-1.51331708465322,-4.88185331545435,-0.418852654157606,"XRCC5","X-ray repair cross complementing 5",TRUE
+"232633_at",0.835952408568777,0.416821713754408,-0.827420498214828,-5.61161852726411,-0.395751981771099,"XRCC5","X-ray repair cross complementing 5",TRUE
+"215308_at",0.721658263642493,0.197873323078116,1.32745826793766,-5.11602379238669,0.632148404122153,"XRCC6","X-ray repair cross complementing 6",TRUE
+"200792_at",0.945432830098469,0.753387620884036,0.318100332021879,-5.89051844271407,0.076114106969051,"XRCC6","X-ray repair cross complementing 6",TRUE
+"233632_s_at",0.762670173856783,0.262118630739582,1.15071182512143,-5.31453728725167,0.393315259909935,"XRN1","5'-3' exoribonuclease 1",TRUE
+"1555785_a_at",0.792716268502624,0.324425365126382,1.00781081259905,-5.45673165293345,0.38370093398505,"XRN1","5'-3' exoribonuclease 1",TRUE
+"225814_at",0.892746695408886,0.565498188213935,0.583426773638032,-5.77523979361304,0.218980334110741,"XRN1","5'-3' exoribonuclease 1",TRUE
+"1570394_at",0.928295253101366,0.685352922143282,-0.410539973901347,-5.85792411564984,-0.164071750347302,"XRN1","5'-3' exoribonuclease 1",TRUE
+"223002_s_at",0.954096423385239,0.789417722928239,-0.270317829365258,-5.90415547251593,-0.10024608323647,"XRN2","5'-3' exoribonuclease 2",TRUE
+"233878_s_at",0.959290940418208,0.81550504051619,-0.236124650375329,-5.91256377616755,-0.0874586315953074,"XRN2","5'-3' exoribonuclease 2",TRUE
+"237666_at",0.773754791548713,0.285368204843701,-1.09478828491932,-5.37218367843959,-0.721265599554609,"XRRA1","X-ray radiation resistance associated 1",TRUE
+"230557_at",0.944793138991092,0.751724881933817,-0.32032289833227,-5.88983070904372,-0.266764455485746,"XRRA1","X-ray radiation resistance associated 1",TRUE
+"226891_at",0.783459181417518,0.306061356303553,1.0477233076688,-5.41871439738312,0.958276403072698,"XXYLT1","xyloside xylosyltransferase 1",TRUE
+"208318_s_at",0.839781238235762,0.428602345154649,0.806366287050202,-5.62784943490649,0.729247327101986,"XYLB","xylulokinase",TRUE
+"214776_x_at",0.94895689004559,0.769502392562303,-0.296642481892508,-5.89691415382025,-0.10743195627511,"XYLB","xylulokinase",TRUE
+"208317_at",0.976371465776674,0.886085602029808,-0.144918252773158,-5.92945969565114,-0.120633731619402,"XYLB","xylulokinase",TRUE
+"1569683_at",0.998347572104896,0.992232739645974,-0.00984540772113877,-5.93963626883011,-0.00263761641158577,"XYLB","xylulokinase",TRUE
+"232574_at",0.821424121108148,0.38356012702725,0.888987331398428,-5.56191893295959,0.639012160254629,"XYLT1","xylosyltransferase 1",TRUE
+"213725_x_at",0.908709061737317,0.620726681052252,0.501845507156595,-5.81775605948506,0.350014460508599,"XYLT1","xylosyltransferase 1",TRUE
+"219401_at",0.787929163003677,0.313958582221149,-1.03035873269127,-5.43541812766113,-0.445507952903002,"XYLT2","xylosyltransferase 2",TRUE
+"1570528_at",0.870857065562116,0.510680437405366,0.6685625449359,-5.72429191444849,0.312165426455774,"XYLT2","xylosyltransferase 2",TRUE
+"231550_at",0.93789466363241,0.725490867456307,-0.355616816676488,-5.87827487137388,-0.31136903983154,"XYLT2","xylosyltransferase 2",TRUE
+"223433_at",0.854400503339099,0.465933673768621,-0.741910995533201,-5.67508663887395,-0.220956686312293,"YAE1D1","Yae1 domain containing 1",TRUE
+"206238_s_at",0.609970971583967,0.0820434663928394,-1.82161188469828,-4.44106380132844,-0.623818910584021,"YAF2","YY1 associated factor 2",TRUE
+"244783_at",0.745510155593313,0.23713179417602,-1.21506355217348,-5.24509150177021,-0.516263164279529,"YAF2","YY1 associated factor 2",TRUE
+"224895_at",0.819018525257656,0.373245519186688,0.908780699602878,-5.54523852782718,0.482243222544577,"YAP1","Yes associated protein 1",TRUE
+"224894_at",0.839466826665106,0.4257664447103,0.811401173195285,-5.62400368177225,0.432903008435696,"YAP1","Yes associated protein 1",TRUE
+"213342_at",0.868397087637799,0.504094514186746,0.679120576166501,-5.7175101749556,0.396480789596755,"YAP1","Yes associated protein 1",TRUE
+"238760_at",0.690381347688918,0.160095940934159,1.4535265138507,-4.95991792685385,0.461197367737989,"YARS","tyrosyl-tRNA synthetase",TRUE
+"212048_s_at",0.875220799430778,0.522319500600259,-0.650087698995351,-5.73591381826753,-0.170863985658245,"YARS","tyrosyl-tRNA synthetase",TRUE
+"218470_at",0.956462414390747,0.802798658597271,0.252740652484359,-5.90861874454721,0.0897242101167492,"YARS2","tyrosyl-tRNA synthetase 2",TRUE
+"227421_at",0.899998627338565,0.594297136667874,0.540422417464088,-5.79842604795688,0.259808979077716,"YBEY","ybeY metallopeptidase (putative)",TRUE
+"242565_x_at",0.992376456171815,0.964569949891884,0.0449244663903392,-5.93870053400598,0.03469057665429,"YBEY","ybeY metallopeptidase (putative)",TRUE
+"239208_s_at",0.998236374734397,0.991700140218532,0.0105205304777515,-5.93962957198504,0.00565426622748344,"YBEY","ybeY metallopeptidase (putative)",TRUE
+"208627_s_at",0.773107052530371,0.283903248872511,1.09821201259908,-5.36872766299841,0.372438605886515,"YBX1","Y-box binding protein 1",TRUE
+"208628_s_at",0.849935057946582,0.451751918886534,0.766014260851585,-5.65785685101534,0.209192245048872,"YBX1","Y-box binding protein 1",TRUE
+"216940_x_at",0.91214506476306,0.631719890668825,0.48602745638118,-5.82527847472964,0.515457751905635,"YBX1","Y-box binding protein 1",TRUE
+"219704_at",0.0961098855754659,0.000414850169104892,-4.1483229656684,0.119528711543182,-3.7160114610427,"YBX2","Y-box binding protein 2",TRUE
+"228634_s_at",0.571736836402345,0.0597744646733745,1.98404616347423,-4.18516653309884,1.31654929812836,"YBX3","Y-box binding protein 3",TRUE
+"201161_s_at",0.691311047868755,0.161059353045308,1.45002951487423,-4.96440486080163,2.56595863320723,"YBX3","Y-box binding protein 3",TRUE
+"201160_s_at",0.737123149977386,0.222488640928089,1.25518655109623,-5.20013752511861,1.87667637054833,"YBX3","Y-box binding protein 3",TRUE
+"213319_s_at",0.966641191718519,0.845076770869495,0.197707181009589,-5.92066300720041,0.101738539127238,"YBX3","Y-box binding protein 3",TRUE
+"227042_at",0.748437803638032,0.240973575633571,-1.20484888079421,-5.25633434607525,-0.370312680427791,"YDJC","YdjC homolog (bacterial)",TRUE
+"221203_s_at",0.679876113745083,0.147112042356963,1.50240429653097,-4.89629008933783,0.544609331413479,"YEATS2","YEATS domain containing 2",TRUE
+"1557047_at",0.850536169066796,0.453297504572175,0.763365525942467,-5.65977573197718,0.220319460677445,"YEATS2","YEATS domain containing 2",TRUE
+"218911_at",0.84571977676742,0.44356473189098,-0.780137421224355,-5.64751938977898,-0.379280690332363,"YEATS4","YEATS domain containing 4",TRUE
+"202932_at",0.683017520100356,0.151169127856078,1.48676697095677,-4.91683091029772,1.02067643750773,"YES1","YES proto-oncogene 1, Src family tyrosine kinase",TRUE
+"202933_s_at",0.754782975475398,0.248405392971272,1.18543140709447,-5.27747874644225,0.869334766088128,"YES1","YES proto-oncogene 1, Src family tyrosine kinase",TRUE
+"210917_at",0.975514010346705,0.883328199558864,0.148452847996462,-5.92895515982164,0.11856258245543,"YES1","YES proto-oncogene 1, Src family tyrosine kinase",TRUE
+"202418_at",0.97580093550434,0.884349531100763,-0.14714342381877,-5.92914348461889,-0.0505184160534746,"YIF1A","Yip1 interacting factor homolog A, membrane trafficking protein",TRUE
+"231211_s_at",0.761748280722165,0.260957081231229,1.15359971836846,-5.31149168273471,1.03729202645312,"YIF1B","Yip1 interacting factor homolog B, membrane trafficking protein",TRUE
+"226437_at",0.912722788750542,0.634147483560111,0.482551436432095,-5.82689997591311,0.180776479974423,"YIF1B","Yip1 interacting factor homolog B, membrane trafficking protein",TRUE
+"1554553_s_at",0.968870165845344,0.852990805713782,0.187479685000516,-5.92257836393362,0.0721189985618551,"YIF1B","Yip1 interacting factor homolog B, membrane trafficking protein",TRUE
+"220207_at",0.983777183253528,0.920644509961081,-0.100763426351532,-5.93473940789424,-0.0323968691561616,"YIF1B","Yip1 interacting factor homolog B, membrane trafficking protein",TRUE
+"214733_s_at",0.593339168375633,0.0701919776357251,-1.90243192402581,-4.3156447897338,-0.72559527707133,"YIPF1","Yip1 domain family member 1",TRUE
+"219075_at",0.51531387545335,0.0355744706270539,2.23822407503479,-3.75606969911579,0.866526124556122,"YIPF2","Yip1 domain family member 2",TRUE
+"65086_at",0.632949074657601,0.104102556571301,1.69491219372878,-4.62968478351334,0.547044673291623,"YIPF2","Yip1 domain family member 2",TRUE
+"221939_at",0.917601067333473,0.650617636219041,0.459123963883169,-5.83753137185656,0.14060349934536,"YIPF2","Yip1 domain family member 2",TRUE
+"216338_s_at",0.896115372949367,0.577138696517712,-0.565915017120288,-5.78488913508828,-0.23553851530324,"YIPF3","Yip1 domain family member 3",TRUE
+"213999_at",0.705100208997726,0.176854276612304,1.39496500897271,-5.03388881843573,0.842851571867029,"YIPF4","Yip1 domain family member 4",TRUE
+"209551_at",0.772202741217767,0.282559693683783,1.1013632723707,-5.36553820405788,0.467879855808363,"YIPF4","Yip1 domain family member 4",TRUE
+"235220_at",0.922329609270161,0.668362123809489,0.434172086572748,-5.84828419103102,0.199305520018145,"YIPF4","Yip1 domain family member 4",TRUE
+"242818_x_at",0.933846143312497,0.706853637695248,0.380970408240393,-5.86923807598804,0.126637433791262,"YIPF4","Yip1 domain family member 4",TRUE
+"221423_s_at",0.754513748034606,0.247894371468849,1.1867525342758,-5.27604960899136,0.40689893385065,"YIPF5","Yip1 domain family member 5",TRUE
+"224949_at",0.877064332746282,0.526142351161322,0.644069246079864,-5.73963232971434,0.225543476467376,"YIPF5","Yip1 domain family member 5",TRUE
+"224934_at",0.884815577925557,0.544893046943374,0.614887150189693,-5.7571906391168,0.217490620355088,"YIPF5","Yip1 domain family member 5",TRUE
+"224953_at",0.941106542715586,0.73611995114539,0.341264026075603,-5.88311820234829,0.170303078261183,"YIPF5","Yip1 domain family member 5",TRUE
+"212343_at",0.738061563377262,0.224988972598241,-1.24819597082919,-5.20806019985147,-0.750653710118221,"YIPF6","Yip1 domain family member 6",TRUE
+"212340_at",0.947778780715578,0.761362923227166,-0.307462295670477,-5.89374450904398,-0.092130454947938,"YIPF6","Yip1 domain family member 6",TRUE
+"212342_at",0.976371465776674,0.887001865303478,-0.143744155026918,-5.92962460446498,-0.0565577511016055,"YIPF6","Yip1 domain family member 6",TRUE
+"212341_at",0.989143673229517,0.947191999016024,-0.0669880877109727,-5.93749806809352,-0.0230385210604638,"YIPF6","Yip1 domain family member 6",TRUE
+"229961_x_at",0.975449397348071,0.882734346810475,-0.149214334128648,-5.92884487525576,-0.110762821531208,"YJEFN3","YjeF N-terminal domain containing 3",TRUE
+"217785_s_at",0.914745343586712,0.640714909519831,0.473177668084147,-5.83121592975561,0.187352731078972,"YKT6","YKT6 v-SNARE homolog (S. cerevisiae)",TRUE
+"217784_at",0.975398143273847,0.881924165234135,0.150253360425716,-5.92869348682821,0.0478385397374286,"YKT6","YKT6 v-SNARE homolog (S. cerevisiae)",TRUE
+"212787_at",0.809109571194383,0.35232227303039,-0.950076909373005,-5.50934846149858,-0.249389611607896,"YLPM1","YLP motif containing 1",TRUE
+"1557065_at",0.941400961503247,0.738029897767626,-0.338692780922915,-5.88396503276066,-0.25354745120671,"YLPM1","YLP motif containing 1",TRUE
+"214713_at",0.942303845415102,0.740826618160734,-0.334931916862846,-5.88519225119358,-0.0801536051386442,"YLPM1","YLP motif containing 1",TRUE
+"214659_x_at",0.955904644595647,0.800534832652605,0.25570854391486,-5.90788603852752,0.0712313074024742,"YLPM1","YLP motif containing 1",TRUE
+"215769_at",0.67842163564685,0.145858930362305,1.50730534866446,-4.88981671793759,0.687986660440648,"YME1L1","YME1 like 1 ATPase",TRUE
+"217397_at",0.691497416459637,0.161166009656061,1.44964341131022,-4.96489972397334,0.669570027415987,"YME1L1","YME1 like 1 ATPase",TRUE
+"217143_s_at",0.715352956634026,0.190973330801226,1.34896781939873,-5.09022280133532,0.891308552702041,"YME1L1","YME1 like 1 ATPase",TRUE
+"215540_at",0.812302873476553,0.356982019987794,-0.940740462119001,-5.51759083540022,-0.438337099299378,"YME1L1","YME1 like 1 ATPase",TRUE
+"217063_x_at",0.822173415758858,0.386197241566227,0.883983002954566,-5.56608235578893,0.796628997668184,"YME1L1","YME1 like 1 ATPase",TRUE
+"211902_x_at",0.830635993561085,0.404081099890967,-0.850617193726173,-5.59328311982587,-0.329554737287113,"YME1L1","YME1 like 1 ATPase",TRUE
+"234849_at",0.833947935066508,0.41174720113513,0.836604932792131,-5.60441549514998,0.399934518444301,"YME1L1","YME1 like 1 ATPase",TRUE
+"201351_s_at",0.839519981963042,0.428201498101038,-0.807076693868427,-5.62730817273742,-0.205576271387411,"YME1L1","YME1 like 1 ATPase",TRUE
+"234427_at",0.857316604145187,0.47251362782364,-0.730876091595001,-5.68280047696808,-0.420478346337671,"YME1L1","YME1 like 1 ATPase",TRUE
+"201352_at",0.885794891933128,0.547651601314305,-0.610639582035858,-5.75968093244707,-0.177331639935641,"YME1L1","YME1 like 1 ATPase",TRUE
+"216304_x_at",0.909441542080538,0.623657599960806,-0.497615692488982,-5.81979062853244,-0.122076839984519,"YME1L1","YME1 like 1 ATPase",TRUE
+"234964_at",0.910965520291016,0.628587035830254,0.490522326722933,-5.82316483388276,0.132698059047776,"YME1L1","YME1 like 1 ATPase",TRUE
+"234013_at",0.914242258486146,0.639170770028245,0.47537774156096,-5.83021039083313,0.382791220574412,"YME1L1","YME1 like 1 ATPase",TRUE
+"213830_at",0.925511384407886,0.677886187196868,0.420895211094453,-5.8537653087085,0.261347948391467,"YME1L1","YME1 like 1 ATPase",TRUE
+"234402_at",0.937113154905832,0.720421879908445,-0.362488347838504,-5.87588631589856,-0.219190773812636,"YME1L1","YME1 like 1 ATPase",TRUE
+"216540_at",0.940378649752914,0.733469547667362,0.344835997621867,-5.88193127721063,0.116851337606834,"YME1L1","YME1 like 1 ATPase",TRUE
+"224343_x_at",0.955892698633978,0.799708759792358,0.256792114464384,-5.90761641098203,0.12336959287072,"YME1L1","YME1 like 1 ATPase",TRUE
+"232216_at",0.957571530817866,0.809409350114226,0.244087147048375,-5.91070656320385,0.107265466302435,"YME1L1","YME1 like 1 ATPase",TRUE
+"216133_at",0.971216837324271,0.863039585020969,-0.17452268344188,-5.92485930989954,-0.142548263832116,"YME1L1","YME1 like 1 ATPase",TRUE
+"217056_at",0.994943851647199,0.976273798909814,-0.0300784292624355,-5.93924283854279,-0.027409079523224,"YME1L1","YME1 like 1 ATPase",TRUE
+"215150_at",0.724568343940805,0.20173155798802,1.31568562452296,-5.12999738422715,0.986330633842363,"YOD1","YOD1 deubiquitinase",TRUE
+"227309_at",0.879841194727839,0.534663442063694,0.630739385222287,-5.74774984006939,0.754649718937019,"YOD1","YOD1 deubiquitinase",TRUE
+"228296_at",0.854397708228594,0.4653205406113,0.74294393748827,-5.67435895963567,0.204131825323645,"YPEL1","yippee like 1",TRUE
+"213996_at",0.940938843113333,0.735524192333256,0.342066539356177,-5.88285260068547,0.295413960461629,"YPEL1","yippee like 1",TRUE
+"228788_at",0.985498770484702,0.929306333614371,-0.0897320778847809,-5.9357624843421,-0.0605759370024277,"YPEL1","yippee like 1",TRUE
+"227020_at",0.87003623115741,0.508193453648707,-0.672540451642953,-5.72174872669869,-0.495581151870526,"YPEL2","yippee like 2",TRUE
+"1556420_s_at",0.944801723928361,0.751843951656742,0.320163684443527,-5.88988013261694,0.206095085575137,"YPEL2","yippee like 2",TRUE
+"229060_at",0.953983577550391,0.788215973870775,-0.271900627182063,-5.9037389400808,-0.240086021393826,"YPEL2","yippee like 2",TRUE
+"232077_s_at",0.877861946695164,0.529230839218392,0.639224355721937,-5.74260161102949,0.576152311893296,"YPEL3","yippee like 3",TRUE
+"223179_at",0.923494952314901,0.671739413478707,-0.429455069764689,-5.85025067794899,-0.209792888285982,"YPEL3","yippee like 3",TRUE
+"235916_at",0.76469251347209,0.264795476771345,1.14409232227762,-5.32149295315187,0.755717799765212,"YPEL4","yippee like 4",TRUE
+"217783_s_at",0.868039927215454,0.501800854578277,0.682815803109877,-5.71511260909475,0.265993083764942,"YPEL5","yippee like 5",TRUE
+"222408_s_at",0.993225426079816,0.967864044101916,0.0407450922963001,-5.93887490913202,0.0157592100184907,"YPEL5","yippee like 5",TRUE
+"218647_s_at",0.774230543658252,0.286282969068034,-1.09265684006935,-5.37433037302875,-0.441602071381615,"YRDC","yrdC N6-threonylcarbamoyltransferase domain containing",TRUE
+"222703_s_at",0.92777930247318,0.683165701861812,0.413568542685805,-5.8567183423132,0.140625344297716,"YRDC","yrdC N6-threonylcarbamoyltransferase domain containing",TRUE
+"228556_at",0.723973974120865,0.200877829114832,1.31827537581757,-5.12693247617905,0.409444887004001,"YTHDC1","YTH domain containing 1",TRUE
+"239905_at",0.840196220146749,0.429242614970993,0.805232416141954,-5.62871240896386,0.452549806977852,"YTHDC1","YTH domain containing 1",TRUE
+"212455_at",0.841550580403629,0.432816653513461,-0.798922256615147,-5.63349414436226,-0.179250405843606,"YTHDC1","YTH domain containing 1",TRUE
+"240459_at",0.932091525948902,0.700120038648897,0.390192626905201,-5.8657988231984,0.117652557848603,"YTHDC1","YTH domain containing 1",TRUE
+"214814_at",0.96200396340887,0.827389328609182,0.220645057473492,-5.91599896177408,0.1049496989179,"YTHDC1","YTH domain containing 1",TRUE
+"213077_at",0.593339168375633,0.0701240293505242,-1.90292866472178,-4.31486209702583,-0.691148617681216,"YTHDC2","YTH domain containing 2",TRUE
+"205835_s_at",0.64513208805899,0.116176070982514,-1.63500883180873,-4.71530655697394,-0.676502813795773,"YTHDC2","YTH domain containing 2",TRUE
+"205836_s_at",0.655235030401569,0.123929995116033,-1.59924500159359,-4.76529589560661,-0.695583207119022,"YTHDC2","YTH domain containing 2",TRUE
+"1568680_s_at",0.948137447885351,0.76445803594202,-0.303343611713842,-5.89496433624705,-0.126129567100842,"YTHDC2","YTH domain containing 2",TRUE
+"221741_s_at",0.436530985944365,0.0199363122433119,-2.50840048939142,-3.26676032093324,-0.755175257146478,"YTHDF1","YTH N6-methyladenosine RNA binding protein 1",TRUE
+"217812_at",0.711902920992134,0.18554598442168,-1.36632022691306,-5.06915555232201,-0.348605566946336,"YTHDF2","YTH N6-methyladenosine RNA binding protein 2",TRUE
+"222430_s_at",0.896118635245982,0.578097739530527,-0.564480264451885,-5.78566708323202,-0.147547235448847,"YTHDF2","YTH N6-methyladenosine RNA binding protein 2",TRUE
+"1564053_a_at",0.745510155593313,0.237101037701813,-1.21514583070471,-5.24500060744013,-0.539045069572479,"YTHDF3","YTH N6-methyladenosine RNA binding protein 3",TRUE
+"221749_at",0.81390353381761,0.364855625157924,-0.925149125624189,-5.53118842816206,-0.349447410479824,"YTHDF3","YTH N6-methyladenosine RNA binding protein 3",TRUE
+"231071_at",0.904832003218088,0.60940757943623,-0.5182692631085,-5.80969690567531,-0.209101271677777,"YTHDF3-AS1","YTHDF3 antisense RNA 1 (head to head)",TRUE
+"217718_s_at",0.873405654736848,0.518671607858458,-0.655853311401315,-5.73232039142613,-0.187067453322154,"YWHAB","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta",TRUE
+"217717_s_at",0.975265330414469,0.880146396392388,0.152533875018011,-5.92835753569989,0.0520902078097087,"YWHAB","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta",TRUE
+"208743_s_at",0.983569686719305,0.920103132448693,-0.101453313827234,-5.93467149274278,-0.0344146366464546,"YWHAB","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta",TRUE
+"210996_s_at",0.910165867297668,0.626244243763755,-0.493890356710225,-5.8215686131129,-0.124521595815029,"YWHAE","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon",TRUE
+"210317_s_at",0.916611653944398,0.647336548582626,0.463769872173539,-5.83546422994203,0.177355202161879,"YWHAE","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon",TRUE
+"1563945_at",0.848600508270547,0.449032671326478,0.770687684026436,-5.65445586976483,0.38702869894397,"YWHAEP7","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon pseudogene 7",TRUE
+"240979_at",0.985498770484702,0.929894695904979,-0.0889831928470325,-5.93582764642468,-0.0378138257517646,"YWHAEP7","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon pseudogene 7",TRUE
+"222985_at",0.930550700810831,0.692751809329735,0.400323680927405,-5.86192722120047,0.0985339941709515,"YWHAG","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma",TRUE
+"242325_at",0.784789297644843,0.309045282983493,1.04112541699391,-5.42509079618252,0.57667174369035,"YWHAH","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta",TRUE
+"201020_at",0.951810226174863,0.778750103240108,0.284393120924369,-5.90036668084566,0.127153347919835,"YWHAH","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta",TRUE
+"236559_at",0.986342822130003,0.93542173768742,0.081950693927364,-5.93641293488107,0.0616086508264839,"YWHAH","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta",TRUE
+"200693_at",0.819018525257656,0.375266717098755,0.904873957835804,-5.54855773327549,0.19791145397549,"YWHAQ","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta",TRUE
+"212426_s_at",0.891444650197327,0.561119490476129,0.59006167107666,-5.77150949372025,0.172294881618004,"YWHAQ","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta",TRUE
+"213699_s_at",0.893928800286346,0.570069600748248,0.57652794982925,-5.77907518511189,0.12494021038119,"YWHAQ","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta",TRUE
+"214848_at",0.724970327905974,0.203047150368314,1.31171149677863,-5.13469076685777,0.761565566864496,"YWHAZ","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta",TRUE
+"200640_at",0.819780516863333,0.377570549074652,0.900437823651245,-5.55231069736662,0.269916699238346,"YWHAZ","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta",TRUE
+"200641_s_at",0.884749233889577,0.544225837022832,0.615916218464205,-5.7565848052437,0.269401887109249,"YWHAZ","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta",TRUE
+"200638_s_at",0.90344422113846,0.603836974072593,0.526405117439772,-5.80561097810997,0.151632425727957,"YWHAZ","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta",TRUE
+"200639_s_at",0.90344422113846,0.604465282348809,0.525485683347152,-5.80607583565469,0.129897899652301,"YWHAZ","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta",TRUE
+"201902_s_at",0.71611852101483,0.191752172184633,-1.34650966981144,-5.09318898582776,-0.523244458178044,"YY1","YY1 transcription factor",TRUE
+"200047_s_at",0.73759219552868,0.224081846986462,-1.2507252736738,-5.20519803584123,-0.30248391121212,"YY1","YY1 transcription factor",TRUE
+"201901_s_at",0.805168768064335,0.344435476092803,-0.966071622097324,-5.49505491881621,-0.278597854551364,"YY1","YY1 transcription factor",TRUE
+"213494_s_at",0.947926063538122,0.763024427529376,0.305250652324902,-5.8944015563953,0.0823674670804984,"YY1","YY1 transcription factor",TRUE
+"224718_at",0.955892698633978,0.799934810888946,0.256495569122018,-5.90769031369489,0.0857622021297306,"YY1","YY1 transcription factor",TRUE
+"224711_at",0.992342196993659,0.964250914309667,-0.0453292843572853,-5.93868274024847,-0.0136879305426625,"YY1","YY1 transcription factor",TRUE
+"217836_s_at",0.629618998226163,0.100589336067774,-1.71344764401824,-4.60272041336228,-0.602547446919608,"YY1AP1","YY1 associated protein 1",TRUE
+"216531_at",0.99783553534859,0.989894949607965,-0.0128088283404173,-5.93960357052483,-0.00405632957214053,"YY2///MBTPS2","YY2 transcription factor///membrane bound transcription factor peptidase, site 2",TRUE
+"1555550_at",0.820480477433428,0.379574452605416,-0.896593693630058,-5.55554903565542,-0.403758237643726,"ZACN","zinc activated ion channel",TRUE
+"243417_at",0.304824368772306,0.00598800422007383,-3.03928975451134,-2.22829528337841,-1.14069694065777,"ZADH2","zinc binding alcohol dehydrogenase domain containing 2",TRUE
+"227049_at",0.5897618614591,0.0679733043292496,-1.91887415266501,-4.28966202998312,-0.810595406436784,"ZADH2","zinc binding alcohol dehydrogenase domain containing 2",TRUE
+"227978_s_at",0.597654932724127,0.0744215308103509,-1.87231035789255,-4.36283830435399,-0.799059721275806,"ZADH2","zinc binding alcohol dehydrogenase domain containing 2",TRUE
+"227977_at",0.728262401376535,0.208525070104072,-1.29537595055169,-5.15385649614272,-0.594629237819236,"ZADH2","zinc binding alcohol dehydrogenase domain containing 2",TRUE
+"234977_at",0.804264099955266,0.342932034060487,-0.969148870860843,-5.4922799466185,-0.2802842682238,"ZADH2","zinc binding alcohol dehydrogenase domain containing 2",TRUE
+"237776_at",0.854400503339099,0.465703971280189,-0.742297879397256,-5.67481420224684,-0.590168815543907,"ZADH2","zinc binding alcohol dehydrogenase domain containing 2",TRUE
+"1554239_s_at",0.928295253101366,0.685361722060682,-0.410527796862419,-5.85792894613299,-0.230436421167076,"ZADH2","zinc binding alcohol dehydrogenase domain containing 2",TRUE
+"225662_at",0.914785556066135,0.641228284156097,0.472446742497751,-5.83154898757685,0.397162690895492,"ZAK","sterile alpha motif and leucine zipper containing kinase AZK",TRUE
+"223519_at",0.922168942129244,0.66758927104646,0.435252925222184,-5.84783062733569,0.332128771866165,"ZAK","sterile alpha motif and leucine zipper containing kinase AZK",TRUE
+"238613_at",0.935999751372286,0.714098904965563,0.3710848277106,-5.87283462275261,0.255042005495529,"ZAK","sterile alpha motif and leucine zipper containing kinase AZK",TRUE
+"1555259_at",0.940227139261806,0.732759072483391,-0.345794287059288,-5.88161076999731,-0.261526834995397,"ZAK","sterile alpha motif and leucine zipper containing kinase AZK",TRUE
+"225665_at",0.954449231029359,0.790918108651078,0.268342692826702,-5.90467186678397,0.216715108763994,"ZAK","sterile alpha motif and leucine zipper containing kinase AZK",TRUE
+"218833_at",0.97689149311934,0.8900317213577,0.139863167537873,-5.93016018418079,0.0651015299572721,"ZAK","sterile alpha motif and leucine zipper containing kinase AZK",TRUE
+"222757_s_at",0.988404412848227,0.944710339398676,0.0701414052578992,-5.93728750348145,0.0329226521000656,"ZAK","sterile alpha motif and leucine zipper containing kinase AZK",TRUE
+"224264_x_at",0.712948021516228,0.186953699863242,1.3617813987376,-5.07468776894087,0.464581699887597,"ZAN","zonadhesin (gene/pseudogene)",TRUE
+"224267_x_at",0.746259710622309,0.237827529706848,1.21320449648544,-5.24714380740605,0.49754930961674,"ZAN","zonadhesin (gene/pseudogene)",TRUE
+"224265_s_at",0.835952408568777,0.416922170976395,-0.827239393997419,-5.61175981313216,-0.309574697064442,"ZAN","zonadhesin (gene/pseudogene)",TRUE
+"224263_x_at",0.852855949428146,0.458967948616705,0.75369415792706,-5.66672879299943,0.531555891507154,"ZAN","zonadhesin (gene/pseudogene)",TRUE
+"224268_x_at",0.858641716553081,0.474439200120679,0.727663975049336,-5.6850252509114,0.241011222174873,"ZAN","zonadhesin (gene/pseudogene)",TRUE
+"214032_at",0.932249295738588,0.701188927897378,0.388726413791459,-5.86635104024518,0.278151486805912,"ZAP70","zeta chain of T cell receptor associated protein kinase 70",TRUE
+"1555613_a_at",0.957289701021675,0.806659190159047,-0.247684799807029,-5.90984734351561,-0.154487120034954,"ZAP70","zeta chain of T cell receptor associated protein kinase 70",TRUE
+"1555775_a_at",0.789661545166663,0.317276533957128,1.02315486318315,-5.44227394838273,0.379624555257594,"ZAR1","zygote arrest 1",TRUE
+"1555774_at",0.895370220688938,0.573773110697127,0.570959555986665,-5.78213870040308,0.287872664238441,"ZAR1","zygote arrest 1",TRUE
+"220269_at",0.943464796017993,0.746640657076565,0.327129208726827,-5.88769513038451,0.203108664548279,"ZBBX","zinc finger B-box domain containing",TRUE
+"203043_at",0.903906029494077,0.605496750078063,-0.523977279643017,-5.80683675690375,-0.208194465449386,"ZBED1","zinc finger BED-type containing 1",TRUE
+"1554821_a_at",0.997056683282451,0.985022470882718,0.018985670985992,-5.93950791759115,0.00762373618836243,"ZBED1","zinc finger BED-type containing 1",TRUE
+"219836_at",0.0823353801878483,0.000293211056947728,4.28991918538789,0.425506247255033,3.92433301805571,"ZBED2","zinc finger BED-type containing 2",TRUE
+"228402_at",0.854184492233394,0.464297772325324,-0.744668790812041,-5.67314170855348,-0.345300765750956,"ZBED3","zinc finger BED-type containing 3",TRUE
+"235109_at",0.862634144901168,0.486009733873536,-0.708521373006235,-5.69809048543561,-0.499215263931445,"ZBED3","zinc finger BED-type containing 3",TRUE
+"1564475_s_at",0.189644672791897,0.00190830767541237,-3.521219065709,-1.22593083005898,-1.75617919456913,"ZBED3-AS1","ZBED3 antisense RNA 1",TRUE
+"241423_at",0.805746717966166,0.345712488280634,0.963465018284876,-5.49739917044972,0.584366046722418,"ZBED3-AS1","ZBED3 antisense RNA 1",TRUE
+"1564474_at",0.838350471423215,0.423384238078423,0.815646756091054,-5.62074336312174,0.679540854575691,"ZBED3-AS1","ZBED3 antisense RNA 1",TRUE
+"1570204_at",0.984916798133038,0.925764033404195,-0.0942419500606952,-5.93535853323068,-0.0939178029744294,"ZBED3-AS1","ZBED3 antisense RNA 1",TRUE
+"214747_at",0.774230543658252,0.286736445051994,-1.09160204192178,-5.37539134000244,-0.44870542046502,"ZBED4","zinc finger BED-type containing 4",TRUE
+"204799_at",0.962351204352784,0.828449991582292,-0.21926624938132,-5.91629370409738,-0.0942386498093484,"ZBED4","zinc finger BED-type containing 4",TRUE
+"218263_s_at",0.677013732819214,0.144555029062039,-1.51244174418748,-4.88301440458734,-0.54358504015838,"ZBED5","zinc finger BED-type containing 5",TRUE
+"242552_x_at",0.729747638370823,0.212007048725525,-1.28516457695314,-5.16573343423792,-0.829704132890762,"ZBED5","zinc finger BED-type containing 5",TRUE
+"240381_at",0.839519981963042,0.427935975269042,0.807547498208138,-5.62694921821733,0.411443805572171,"ZBED5","zinc finger BED-type containing 5",TRUE
+"235010_at",0.914966942918905,0.641937000717126,-0.471438124492911,-5.83200775289004,-0.229009794081939,"ZBED5-AS1","ZBED5 antisense RNA 1",TRUE
+"243648_at",0.97070558355376,0.860541374208519,0.177740959729933,-5.92430795987731,0.12412822363499,"ZBED6","zinc finger BED-type containing 6",TRUE
+"1565866_a_at",0.986455005400648,0.937201199056513,-0.0796874606924261,-5.93659105858508,-0.0320102152388584,"ZBED6","zinc finger BED-type containing 6",TRUE
+"227598_at",0.980993120443541,0.910497976955243,0.113702055620379,-5.93338861300026,0.0947665171175238,"ZBED6CL","ZBED6 C-terminal like",TRUE
+"220770_s_at",0.859064198633089,0.475828078489337,-0.725351886859032,-5.68662088507891,-0.26911304268052,"ZBED8","zinc finger BED-type containing 8",TRUE
+"244758_at",0.813065886130395,0.362518257775815,0.929753857279042,-5.52719426599161,0.680158487899452,"ZBED9","zinc finger BED-type containing 9",TRUE
+"208087_s_at",0.911028479628096,0.628843355531438,0.490154187601271,-5.82333866024554,0.295785286493653,"ZBP1","Z-DNA binding protein 1",TRUE
+"242020_s_at",0.99753019043878,0.98755671608594,0.0157729287285949,-5.93956230733796,0.00678369259705702,"ZBP1","Z-DNA binding protein 1",TRUE
+"213376_at",0.767011398042819,0.268310217069575,-1.13547522526626,-5.33049469664314,-0.426467637882748,"ZBTB1","zinc finger and BTB domain containing 1",TRUE
+"1557036_at",0.904832003218088,0.610190431478716,0.517128755854405,-5.8102647275218,0.385296667917725,"ZBTB1","zinc finger and BTB domain containing 1",TRUE
+"205092_x_at",0.929088231432081,0.687892354089264,-0.40702860073126,-5.8593111933154,-0.199034388562945,"ZBTB1","zinc finger and BTB domain containing 1",TRUE
+"222863_at",0.68041487556515,0.148121958919612,-1.49847917081246,-4.90146225943554,-1.4571081856904,"ZBTB10","zinc finger and BTB domain containing 10",TRUE
+"219312_s_at",0.739189560382301,0.226255885157728,-1.24467648394627,-5.21203457395675,-1.25879800366007,"ZBTB10","zinc finger and BTB domain containing 10",TRUE
+"228562_at",0.746259710622309,0.237870199432662,-1.21309061357346,-5.24726944002034,-1.4085762243834,"ZBTB10","zinc finger and BTB domain containing 10",TRUE
+"233899_x_at",0.757479140651,0.253623193785657,-1.17205677229585,-5.2918685571667,-1.37856820565789,"ZBTB10","zinc finger and BTB domain containing 10",TRUE
+"236105_at",0.79279559916191,0.324621078977812,-1.00739406932192,-5.45712156396342,-0.93088493602406,"ZBTB10","zinc finger and BTB domain containing 10",TRUE
+"235491_at",0.931370027472813,0.695735476578517,-0.396216166307536,-5.86350869722119,-0.164100709102831,"ZBTB10","zinc finger and BTB domain containing 10",TRUE
+"235726_at",0.958284323245298,0.811338630221273,-0.241565304259721,-5.91130139760406,-0.126542799917615,"ZBTB10","zinc finger and BTB domain containing 10",TRUE
+"204847_at",0.457032025390949,0.0226246510147347,-2.45038930672372,-3.37440903081137,-0.636574560145695,"ZBTB11","zinc finger and BTB domain containing 11",TRUE
+"242433_at",0.954577684533304,0.79235260558869,0.266455312879091,-5.90516180339216,0.122337408094376,"ZBTB11","zinc finger and BTB domain containing 11",TRUE
+"232259_s_at",0.558021698679157,0.0526413796023824,-2.04754592033631,-4.08109968379176,-1.01032658351944,"ZBTB11-AS1","ZBTB11 antisense RNA 1",TRUE
+"232260_at",0.873301865850313,0.518250398001337,0.656520485355364,-5.73190260912959,0.514843300003993,"ZBTB11-AS1","ZBTB11 antisense RNA 1",TRUE
+"233843_at",0.928777626237599,0.686624447234088,0.408781132249614,-5.85862036632299,0.236700505709527,"ZBTB12","zinc finger and BTB domain containing 12",TRUE
+"209724_s_at",0.932249295738588,0.701194696624668,0.388718503088464,-5.86635401408133,0.105270272272953,"ZBTB14","zinc finger and BTB domain containing 14",TRUE
+"208199_s_at",0.995025131654789,0.976783477608031,-0.0294320968565045,-5.93926157193569,-0.00720885776363733,"ZBTB14","zinc finger and BTB domain containing 14",TRUE
+"205883_at",0.896118635245982,0.577895534034246,-0.564782669318262,-5.78550327325779,-0.418607403766961,"ZBTB16","zinc finger and BTB domain containing 16",TRUE
+"203601_s_at",0.60921532501728,0.0815686513003312,-1.82464802891845,-4.4364224035063,-1.24315566553463,"ZBTB17","zinc finger and BTB domain containing 17",TRUE
+"203602_s_at",0.670055900335625,0.135726915340047,-1.54825504006997,-4.83507421056337,-0.463841421246158,"ZBTB17","zinc finger and BTB domain containing 17",TRUE
+"207164_s_at",0.871165715950006,0.511785659123831,0.666798229525474,-5.72541526559111,0.717851541188558,"ZBTB18","zinc finger and BTB domain containing 18",TRUE
+"212774_at",0.931038852978249,0.694803093586167,0.397498998304628,-5.86301650598377,0.538736808775688,"ZBTB18","zinc finger and BTB domain containing 18",TRUE
+"226284_at",0.874623344533688,0.521084535695854,-0.652037111045414,-5.73470225144002,-0.210954242697312,"ZBTB2","zinc finger and BTB domain containing 2",TRUE
+"226252_at",0.280199223932988,0.00457877143697374,3.15385926031272,-1.99399352898553,1.55018067921523,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"226250_at",0.346088453194087,0.00885556005520856,2.87005710402997,-2.56854734676861,1.14604799525211,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"235308_at",0.399312926596283,0.0141758827713468,2.66240563423366,-2.9748189076603,1.63487893245462,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"205383_s_at",0.471793372004737,0.0257577177034136,2.39036172987764,-3.48436583429002,1.52659752242579,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"232125_at",0.561683712684032,0.0548174538798719,2.02740133880361,-4.11434943465871,2.37962580081749,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"227082_at",0.57460012602512,0.0605047587637,1.9779307366725,-4.19507280016944,2.23382738818559,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"213158_at",0.579119470758542,0.0622242340180248,1.96378604295282,-4.21790614303833,1.78637932793126,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"232929_at",0.585036027492332,0.0655264347357361,1.9375635983276,-4.25994036494706,1.13401649494548,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"227121_at",0.603702127972549,0.0783434610100438,1.84568676027399,-4.4041081293717,1.19325622652011,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"213156_at",0.622434989367596,0.0928031785915623,1.75657990252098,-4.53912919116346,2.39208661820364,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"244581_at",0.630603891142543,0.101696997202495,1.70754508474717,-4.611331011962,0.939679513311885,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"222357_at",0.697699759202153,0.168503797931795,1.42356125968438,-4.99807956816464,1.12410260738284,"ZBTB20","zinc finger and BTB domain containing 20",TRUE
+"231497_at",0.627092759817312,0.0987385101907548,1.72343511287859,-4.58810021251141,0.622001015169933,"ZBTB20-AS1","ZBTB20 antisense RNA 1",TRUE
+"225539_at",0.728156825353177,0.20833875263346,-1.29592606022136,-5.15321439213119,-0.408226784596502,"ZBTB21","zinc finger and BTB domain containing 21",TRUE
+"233952_s_at",0.728385463227073,0.208853463665511,-1.29440728179486,-5.15498659185735,-0.494824547731502,"ZBTB21","zinc finger and BTB domain containing 21",TRUE
+"213081_at",0.999096141648529,0.99706779831569,0.00371666479860337,-5.93967675265744,0.00123101121026536,"ZBTB22","zinc finger and BTB domain containing 22",TRUE
+"1554037_a_at",0.724275694298914,0.2015387364072,1.31626979294795,-5.12930647947219,0.661613106735178,"ZBTB24","zinc finger and BTB domain containing 24",TRUE
+"205340_at",0.945644577306271,0.754684349286099,0.316368142788768,-5.89105114983528,0.112462068337907,"ZBTB24","zinc finger and BTB domain containing 24",TRUE
+"1554036_at",0.953718791969982,0.78661086280542,0.274015792504644,-5.90317853952275,0.124417253026801,"ZBTB24","zinc finger and BTB domain containing 24",TRUE
+"214482_at",0.945498722604777,0.754211638489566,-0.31699948228524,-5.89085732508816,-0.157914207571955,"ZBTB25","zinc finger and BTB domain containing 25",TRUE
+"227162_at",0.502394860388381,0.0324071008653519,-2.28258149379458,-3.67792638920369,-0.857299408970327,"ZBTB26","zinc finger and BTB domain containing 26",TRUE
+"1554973_a_at",0.890004112942188,0.558247610042986,-0.594427878490331,-5.76903245576788,-0.320864500679882,"ZBTB26","zinc finger and BTB domain containing 26",TRUE
+"220391_at",0.863918945062466,0.490288814747934,-0.701508979236623,-5.702793577285,-0.269728403257521,"ZBTB3","zinc finger and BTB domain containing 3",TRUE
+"1553858_at",0.917106560962976,0.6496509295191,0.460491717298144,-5.83692492392608,0.253134131977389,"ZBTB3","zinc finger and BTB domain containing 3",TRUE
+"220118_at",0.880842449447422,0.536625928200251,-0.627685713090693,-5.74958644786031,-0.31764778931176,"ZBTB32","zinc finger and BTB domain containing 32",TRUE
+"226255_at",0.861659105448003,0.482993499670076,-0.713485724390547,-5.69473404227376,-0.229393097662152,"ZBTB33","zinc finger and BTB domain containing 33",TRUE
+"214631_at",0.885029460971826,0.545951959773943,-0.613255312661419,-5.75814933318984,-0.242797708980871,"ZBTB33","zinc finger and BTB domain containing 33",TRUE
+"227111_at",0.975398143273847,0.882374291798356,-0.149676069816354,-5.92877772875508,-0.0476208966822309,"ZBTB34","zinc finger and BTB domain containing 34",TRUE
+"223953_s_at",0.411281725160037,0.01631754253535,-2.59925860369668,-3.09556449064293,-1.29711700450975,"ZBTB37","zinc finger and BTB domain containing 37",TRUE
+"231547_at",0.599731655615302,0.0760835748694367,-1.86088194127848,-4.38060507274179,-0.703265188202836,"ZBTB37","zinc finger and BTB domain containing 37",TRUE
+"228216_at",0.744706562599365,0.236235417884535,-1.21746481710609,-5.2424365967064,-0.562387614137488,"ZBTB37","zinc finger and BTB domain containing 37",TRUE
+"236557_at",0.565043084457947,0.0562005575925976,2.0149648476144,-4.13476786467137,0.935994057701382,"ZBTB38","zinc finger and BTB domain containing 38",TRUE
+"230754_at",0.640067422642767,0.110731888078423,1.66133612917718,-4.67796494383498,1.02863501363938,"ZBTB38","zinc finger and BTB domain containing 38",TRUE
+"219221_at",0.67842163564685,0.145826847750043,1.50743127843052,-4.88965016594084,0.930417145361272,"ZBTB38","zinc finger and BTB domain containing 38",TRUE
+"1558733_at",0.700963156261921,0.172667453205841,1.40916464476846,-5.01618230896905,0.820566830145241,"ZBTB38","zinc finger and BTB domain containing 38",TRUE
+"225512_at",0.783317087571455,0.305991520006422,1.04787826997438,-5.41856420184461,0.660342459009536,"ZBTB38","zinc finger and BTB domain containing 38",TRUE
+"205256_at",0.702809964629668,0.17446935728825,-1.40302017675499,-5.02386242829521,-0.425921332413527,"ZBTB39","zinc finger and BTB domain containing 39",TRUE
+"227047_x_at",0.610660880283135,0.0832643714613437,1.81387429102353,-4.45286720520851,0.557731047915496,"ZBTB4","zinc finger and BTB domain containing 4",TRUE
+"225629_s_at",0.801560848966415,0.338612096287931,0.97804257619535,-5.48421460530648,0.33245117543745,"ZBTB4","zinc finger and BTB domain containing 4",TRUE
+"1559728_at",0.708473702007515,0.180532467289247,1.38270963616213,-5.04905163195392,0.847920076069782,"ZBTB40","zinc finger and BTB domain containing 40",TRUE
+"203959_s_at",0.753862100951903,0.247092073398,-1.18883080510876,-5.27379861828058,-0.387180450266344,"ZBTB40","zinc finger and BTB domain containing 40",TRUE
+"203958_s_at",0.761269771869579,0.260364076545124,-1.15507773578363,-5.30993035440796,-0.433283372829844,"ZBTB40","zinc finger and BTB domain containing 40",TRUE
+"226962_at",0.73759219552868,0.224006077970442,-1.25093689115152,-5.20495834355506,-0.551983206054537,"ZBTB41","zinc finger and BTB domain containing 41",TRUE
+"229691_at",0.821424121108148,0.383530156971843,-0.889044333253708,-5.56187138402034,-0.748163924104276,"ZBTB42","zinc finger and BTB domain containing 42",TRUE
+"227991_x_at",0.843816788557882,0.439631135892477,-0.786979540762725,-5.64244726757472,-0.265756107882032,"ZBTB43","zinc finger and BTB domain containing 43",TRUE
+"204182_s_at",0.932269331146744,0.70129916035753,-0.388575255483942,-5.86640785421142,-0.23528946689606,"ZBTB43","zinc finger and BTB domain containing 43",TRUE
+"204180_s_at",0.944646698916914,0.751061874045374,-0.321209592886678,-5.8895550140614,-0.101019679136657,"ZBTB43","zinc finger and BTB domain containing 43",TRUE
+"204181_s_at",0.95194340202313,0.78033978965582,-0.282291970420772,-5.90094438635027,-0.0785311258335231,"ZBTB43","zinc finger and BTB domain containing 43",TRUE
+"231393_x_at",0.98898980125289,0.946735019803841,-0.0675686944984249,-5.93746002479058,-0.0322454736532425,"ZBTB43","zinc finger and BTB domain containing 43",TRUE
+"226148_at",0.933314818367461,0.704981580751364,0.383530935481809,-5.86829130761873,0.193311153591292,"ZBTB44","zinc finger and BTB domain containing 44",TRUE
+"220243_at",0.971826767527606,0.865178518307321,-0.171768739766503,-5.92532313565025,-0.137332307369228,"ZBTB44","zinc finger and BTB domain containing 44",TRUE
+"225845_at",0.984132887597385,0.922251774049913,-0.0987155534860604,-5.93493828151056,-0.0498017421836838,"ZBTB44","zinc finger and BTB domain containing 44",TRUE
+"1554469_at",0.988737747949649,0.945777274701117,0.0687856179173677,-5.93737922316707,0.0257374911093899,"ZBTB44","zinc finger and BTB domain containing 44",TRUE
+"1554470_s_at",0.990980060324272,0.957662716484888,-0.0536907562313525,-5.93827952270903,-0.0251397127706898,"ZBTB44","zinc finger and BTB domain containing 44",TRUE
+"240551_at",0.828070400350931,0.397824157580158,0.862180269038868,-5.58396677624666,0.528006712729267,"ZBTB45","zinc finger and BTB domain containing 45",TRUE
+"229862_x_at",0.903021267024792,0.602911406038395,0.527760383713231,-5.80492432519203,0.204215585031868,"ZBTB45","zinc finger and BTB domain containing 45",TRUE
+"243214_at",0.855405088766616,0.468481938326979,0.737626565493862,-5.67809465124019,0.398930903199375,"ZBTB46","zinc finger and BTB domain containing 46",TRUE
+"227329_at",0.948668195792872,0.766586365950158,-0.300514539798863,-5.89579277341611,-0.194699204821926,"ZBTB46","zinc finger and BTB domain containing 46",TRUE
+"227358_at",0.994057527155985,0.972298260306766,-0.035120351482595,-5.9390827359026,-0.0335042921869553,"ZBTB46","zinc finger and BTB domain containing 46",TRUE
+"224119_at",0.922244100278602,0.668165218111312,0.434447410279878,-5.84816875915748,0.18319110549696,"ZBTB46-AS1","ZBTB46 antisense RNA 1",TRUE
+"226500_at",0.773107052530371,0.283913478344442,1.09818806119602,-5.36875187361923,0.426017647519947,"ZBTB47","zinc finger and BTB domain containing 47",TRUE
+"234338_s_at",0.997263441064271,0.986016917282525,-0.0177249575466896,-5.93953045927725,-0.00797302523957288,"ZBTB47","zinc finger and BTB domain containing 47",TRUE
+"226484_at",0.99783553534859,0.989401218746014,0.0134347037211333,-5.93959557049137,0.0072678395446033,"ZBTB47","zinc finger and BTB domain containing 47",TRUE
+"205025_at",0.819807973515613,0.377754128904086,-0.900085100688311,-5.55260836893735,-0.338746109597931,"ZBTB48","zinc finger and BTB domain containing 48",TRUE
+"229089_at",0.327864702134751,0.00770979829420139,-2.93030336477537,-2.44828076804245,-1.04743995820984,"ZBTB49","zinc finger and BTB domain containing 49",TRUE
+"203026_at",0.822850703882235,0.388467855503464,-0.879692003316787,-5.56963496007125,-0.289485888423389,"ZBTB5","zinc finger and BTB domain containing 5",TRUE
+"206098_at",0.547343369043481,0.0477546670298047,-2.09564484815818,-4.00084338384908,-0.801722217643277,"ZBTB6","zinc finger and BTB domain containing 6",TRUE
+"226554_at",0.61299046462692,0.0845311825417515,-1.80594887977751,-4.46491951601268,-0.632986886527195,"ZBTB7A","zinc finger and BTB domain containing 7A",TRUE
+"213303_x_at",0.62986301194198,0.100978745057375,-1.71136626445132,-4.60575925012548,-0.47291198607827,"ZBTB7A","zinc finger and BTB domain containing 7A",TRUE
+"219186_at",0.744931128252932,0.236681260271705,-1.21626960975579,-5.24375861833394,-0.38707303796822,"ZBTB7A","zinc finger and BTB domain containing 7A",TRUE
+"213299_at",0.842397669245069,0.436199268936501,0.792979689420129,-5.63796498232744,0.543147388074261,"ZBTB7A","zinc finger and BTB domain containing 7A",TRUE
+"222082_at",0.873628468770492,0.519063937960849,0.655232150550979,-5.73270899415617,0.229312927294421,"ZBTB7A","zinc finger and BTB domain containing 7A",TRUE
+"230709_x_at",0.902229953331547,0.600932677835051,0.530661106986592,-5.8034488828131,0.33258880844523,"ZBTB7A","zinc finger and BTB domain containing 7A",TRUE
+"235145_at",0.501591596209182,0.0321639231961356,-2.28614885206225,-3.67160249853873,-1.6697942756394,"ZBTB7B","zinc finger and BTB domain containing 7B",TRUE
+"205853_at",0.950887541143339,0.775697288460148,-0.288431823434271,-5.89924431409282,-0.211651729005785,"ZBTB7B","zinc finger and BTB domain containing 7B",TRUE
+"217675_at",0.841967750949524,0.434627355284685,-0.795737670407251,-5.63589394377627,-0.81117281341771,"ZBTB7C","zinc finger and BTB domain containing 7C",TRUE
+"227782_at",0.872238421308015,0.515133148636606,-0.661467396757868,-5.72879216115587,-0.884638672172816,"ZBTB7C","zinc finger and BTB domain containing 7C",TRUE
+"235142_at",0.932091525948902,0.700435498003797,0.389759815647358,-5.86596204519807,0.124489067260582,"ZBTB8A","zinc finger and BTB domain containing 8A",TRUE
+"1563770_at",0.535243600695458,0.0427005518837408,2.15028666633301,-3.90822487498759,0.945141617682476,"ZBTB8B","zinc finger and BTB domain containing 8B",TRUE
+"228970_at",0.929332398252332,0.689380217801885,-0.404973691600754,-5.86011749331111,-0.12016129593245,"ZBTB8OS","zinc finger and BTB domain containing 8 opposite strand",TRUE
+"226163_at",0.992820830895496,0.966118277858306,0.0429599315303341,-5.93878461858218,0.0122383443977423,"ZBTB9","zinc finger and BTB domain containing 9",TRUE
+"1560197_at",0.947778780715578,0.761955156082711,-0.306673790236362,-5.89397930182875,-0.23054052874572,"ZC2HC1A","zinc finger C2HC-type containing 1A",TRUE
+"205308_at",0.976392182310915,0.88754884060484,0.143043360795401,-5.92972239701927,0.0685451087816968,"ZC2HC1A","zinc finger C2HC-type containing 1A",TRUE
+"241808_at",0.991124129532655,0.958512656116482,-0.0526118400343877,-5.93833537714903,-0.0509850806909551,"ZC2HC1A","zinc finger C2HC-type containing 1A",TRUE
+"237592_at",0.936318756756998,0.715580261410989,0.369068298682253,-5.8735568148478,0.228583950877687,"ZC2HC1B","zinc finger C2HC-type containing 1B",TRUE
+"220107_s_at",0.942684843065067,0.742983175442543,0.332035269232936,-5.88612822324706,0.214665300847511,"ZC2HC1C","zinc finger C2HC-type containing 1C",TRUE
+"243662_at",0.393258278493143,0.013447689722269,-2.68593978987574,-2.92946626774637,-1.71034287632529,"ZC3H10","zinc finger CCCH-type containing 10",TRUE
+"227430_at",0.93613089056626,0.714411018261191,0.370659826562185,-5.8729871540458,0.114676572240606,"ZC3H10","zinc finger CCCH-type containing 10",TRUE
+"240677_at",0.962798893634104,0.830861385858737,-0.216133171472108,-5.916956611975,-0.0644489434110129,"ZC3H10","zinc finger CCCH-type containing 10",TRUE
+"234878_at",0.818686885011389,0.372285329016936,0.91064154071392,-5.54365289828255,0.554601822723503,"ZC3H12B","zinc finger CCCH-type containing 12B",TRUE
+"229234_at",0.854617134545613,0.46623721790995,-0.741399915106516,-5.67544632602193,-0.627781709436184,"ZC3H12B","zinc finger CCCH-type containing 12B",TRUE
+"231899_at",0.456898036702485,0.0224614559678328,2.45372316800217,-3.36825883301047,3.20326563603211,"ZC3H12C","zinc finger CCCH-type containing 12C",TRUE
+"1559763_at",0.731054546207485,0.213894030984598,1.27968478047391,-5.17207404574718,0.972595494018946,"ZC3H12C","zinc finger CCCH-type containing 12C",TRUE
+"1559263_s_at",0.686747966354964,0.155188869039631,1.47160703363911,-4.93657930326838,1.51113759083192,"ZC3H12D","zinc finger CCCH-type containing 12D",TRUE
+"227536_at",0.888773817669969,0.555656489484941,-0.598377264629176,-5.76677668867037,-0.282367873083182,"ZC3H13","zinc finger CCCH-type containing 13",TRUE
+"212402_at",0.899825513763341,0.593725097433916,0.541266403050763,-5.79798758060754,0.181417552232203,"ZC3H13","zinc finger CCCH-type containing 13",TRUE
+"209851_at",0.986447777082985,0.936760037200287,-0.0802485184422451,-5.93654736626064,-0.0426057175529104,"ZC3H13","zinc finger CCCH-type containing 13",TRUE
+"243948_at",0.528412182286162,0.0411129913757441,-2.16865806072041,-3.87674853749511,-0.942765864460127,"ZC3H14","zinc finger CCCH-type containing 14",TRUE
+"213064_at",0.537586664847644,0.0436460394194548,-2.13963652716388,-3.92639527901274,-0.73745944958987,"ZC3H14","zinc finger CCCH-type containing 14",TRUE
+"213063_at",0.622434989367596,0.0930606043649574,-1.75510521528512,-4.5413226825919,-0.687431275281666,"ZC3H14","zinc finger CCCH-type containing 14",TRUE
+"242443_at",0.769847953580141,0.278302254309694,-1.11142126579105,-5.35530400254869,-0.604093751568504,"ZC3H14","zinc finger CCCH-type containing 14",TRUE
+"1559568_at",0.812302873476553,0.356709978625138,0.941283267968953,-5.51711368155889,0.466655381015139,"ZC3H14","zinc finger CCCH-type containing 14",TRUE
+"204216_s_at",0.816800680706682,0.368055603901354,-0.918876829149947,-5.53659966913696,-0.301251275527468,"ZC3H14","zinc finger CCCH-type containing 14",TRUE
+"210709_at",0.636147339487472,0.107395488801466,1.67801497243913,-4.65407331769286,1.55213171697585,"ZC3H15","zinc finger CCCH-type containing 15",TRUE
+"201593_s_at",0.756584150514497,0.25189663362537,1.17645951035735,-5.28714738863542,0.334350843036416,"ZC3H15","zinc finger CCCH-type containing 15",TRUE
+"201595_s_at",0.886284607901624,0.549099310618374,0.608414954886789,-5.76097855773734,0.182263284074837,"ZC3H15","zinc finger CCCH-type containing 15",TRUE
+"226108_at",0.841813886364358,0.433944600522119,-0.796937506305554,-5.63499084512141,-0.269426366577763,"ZC3H18","zinc finger CCCH-type containing 18",TRUE
+"238416_x_at",0.943464796017993,0.746415196938495,0.327431397707551,-5.88759928379086,0.100209290263964,"ZC3H18","zinc finger CCCH-type containing 18",TRUE
+"241056_at",0.773234064853267,0.284448825750228,-1.09693546300143,-5.37001737367404,-0.527151406541646,"ZC3H3","zinc finger CCCH-type containing 3",TRUE
+"213445_at",0.789378278298554,0.315753335767569,1.0264554016698,-5.43913826248941,0.504062320230561,"ZC3H3","zinc finger CCCH-type containing 3",TRUE
+"240022_at",0.797612393661522,0.331215143022452,0.993453808910186,-5.47007995653419,0.779547627058364,"ZC3H4","zinc finger CCCH-type containing 4",TRUE
+"213390_at",0.85334340854827,0.461579884218012,-0.749263409683536,-5.66988617578051,-0.188414281243446,"ZC3H4","zinc finger CCCH-type containing 4",TRUE
+"241372_at",0.861659105448003,0.483033622613314,-0.713419569180386,-5.69477891710784,-0.333932039688634,"ZC3H6","zinc finger CCCH-type containing 6",TRUE
+"227809_at",0.989638901366417,0.94980136731696,-0.0636732471767352,-5.93770898218456,-0.035207999097695,"ZC3H6","zinc finger CCCH-type containing 6",TRUE
+"218348_s_at",0.661974206478491,0.129810710382569,-1.57334605574143,-4.80095934786496,-0.392652580014712,"ZC3H7A","zinc finger CCCH-type containing 7A",TRUE
+"226897_s_at",0.789503009592599,0.316551901072759,-1.02472364321831,-5.4407846617255,-0.283866387991813,"ZC3H7A","zinc finger CCCH-type containing 7A",TRUE
+"213323_s_at",0.579042978161571,0.0620048277263881,1.9655715316668,-4.21503001847064,0.733765584014082,"ZC3H7B","zinc finger CCCH-type containing 7B",TRUE
+"206169_x_at",0.65284137151906,0.121851244846443,1.60864508949515,-4.75223970131347,0.602110283124407,"ZC3H7B","zinc finger CCCH-type containing 7B",TRUE
+"206168_at",0.729041056651108,0.210536662075363,1.28946074528253,-5.16074626098401,1.04698906702724,"ZC3H7B","zinc finger CCCH-type containing 7B",TRUE
+"205877_s_at",0.82064687791745,0.38155150379,0.892814125401682,-5.55872048913962,0.324270182563184,"ZC3H7B","zinc finger CCCH-type containing 7B",TRUE
+"216844_at",0.871744769522775,0.513921536278442,0.66339464175393,-5.72757431694908,0.355413572488554,"ZC3H7B","zinc finger CCCH-type containing 7B",TRUE
+"223506_at",0.811844013927892,0.355971509575464,-0.942758147066662,-5.51581591272344,-0.347743143573979,"ZC3H8","zinc finger CCCH-type containing 8",TRUE
+"239644_at",0.981726750626341,0.912830810212015,0.110725600939476,-5.93371377317385,0.0632431036492971,"ZC3H8","zinc finger CCCH-type containing 8",TRUE
+"213051_at",0.557589172116298,0.0524546781711365,2.0493087014791,-4.07817982753956,0.586969266793014,"ZC3HAV1","zinc finger CCCH-type containing, antiviral 1",TRUE
+"225634_at",0.637485146909712,0.108248464834778,1.67370967356443,-4.66025779260113,0.439951408171352,"ZC3HAV1","zinc finger CCCH-type containing, antiviral 1",TRUE
+"220104_at",0.965914344760007,0.84038460926643,0.203781105885463,-5.91947755367362,0.0999532445422933,"ZC3HAV1","zinc finger CCCH-type containing, antiviral 1",TRUE
+"228280_at",0.851124330077654,0.45423508214188,0.761761414797544,-5.66093477886175,0.864092481361528,"ZC3HAV1L","zinc finger CCCH-type containing, antiviral 1 like",TRUE
+"1553781_at",0.883952384679702,0.542509733202855,0.618566129120013,-5.75502025303112,0.773827879540749,"ZC3HAV1L","zinc finger CCCH-type containing, antiviral 1 like",TRUE
+"223163_s_at",0.954387719376857,0.790242430953074,-0.269232032457171,-5.90443981669352,-0.0757338021343035,"ZC3HC1","zinc finger C3HC-type containing 1",TRUE
+"225784_s_at",0.303059342222774,0.00583213142167122,3.05060100149745,-2.20529602307618,2.59587842316393,"ZC4H2","zinc finger C4H2-type containing",TRUE
+"220040_x_at",0.77938352158119,0.30059928169042,1.0599198662643,-5.40683203196638,0.753355960369927,"ZC4H2","zinc finger C4H2-type containing",TRUE
+"234809_at",0.917368611505791,0.650220133547031,0.459686266220653,-5.83728226668637,0.28100733921939,"ZC4H2","zinc finger C4H2-type containing",TRUE
+"1559399_s_at",0.610033432202476,0.082342974555612,-1.81970454054416,-4.4439767423128,-0.672519070345885,"ZCCHC10","zinc finger CCHC-type containing 10",TRUE
+"221193_s_at",0.64513208805899,0.116349749530421,-1.63418616686481,-4.71646602394646,-0.586534747982837,"ZCCHC10","zinc finger CCHC-type containing 10",TRUE
+"223803_s_at",0.740270784944871,0.228775428017188,-1.2377215932059,-5.21985997992052,-0.391810495213551,"ZCCHC10","zinc finger CCHC-type containing 10",TRUE
+"217594_at",0.71737572552437,0.193123974467182,1.3421990553512,-5.09837954537897,1.16957267019786,"ZCCHC11","zinc finger CCHC-type containing 11",TRUE
+"212704_at",0.728385463227073,0.209480951864879,1.29255964272223,-5.15714014589673,0.884940601684148,"ZCCHC11","zinc finger CCHC-type containing 11",TRUE
+"228715_at",0.971242929121865,0.863562368195694,0.17384945697347,-5.92497337562035,0.056853625855009,"ZCCHC12","zinc finger CCHC-type containing 12",TRUE
+"1554210_at",0.896118635245982,0.577869872315208,0.564821051054794,-5.78548247613516,0.338819149848953,"ZCCHC13","zinc finger CCHC-type containing 13",TRUE
+"212655_at",0.272829633065398,0.00433134195703275,-3.17744713502109,-1.94540118758133,-1.04870468497203,"ZCCHC14","zinc finger CCHC-type containing 14",TRUE
+"215426_at",0.747480715667991,0.239262185732154,1.20938391009886,-5.2513529957192,0.543691985837165,"ZCCHC14","zinc finger CCHC-type containing 14",TRUE
+"215427_s_at",0.980009054680439,0.905545918595709,-0.120023895155672,-5.93266941303576,-0.0409971334435522,"ZCCHC14","zinc finger CCHC-type containing 14",TRUE
+"223107_s_at",0.863334742737547,0.487572934362139,-0.705955548043027,-5.69981651187278,-0.208756992198319,"ZCCHC17","zinc finger CCHC-type containing 17",TRUE
+"223108_s_at",0.959360897375394,0.816408666357244,-0.234945628741075,-5.91283357049735,-0.0619744941392888,"ZCCHC17","zinc finger CCHC-type containing 17",TRUE
+"230224_at",0.681870837658861,0.149494023429662,1.49318137793191,-4.90842598306331,0.596219950507894,"ZCCHC18","zinc finger CCHC-type containing 18",TRUE
+"219062_s_at",0.62986301194198,0.100867576566631,-1.71195975879866,-4.60489302369904,-0.91559162662729,"ZCCHC2","zinc finger CCHC-type containing 2",TRUE
+"222816_s_at",0.824725394917053,0.392187659219815,-0.872697453009935,-5.57539149508013,-0.647790581690153,"ZCCHC2","zinc finger CCHC-type containing 2",TRUE
+"232222_at",0.889810959543386,0.558068254944243,0.594700943796865,-5.76887695382726,0.370765167840824,"ZCCHC2","zinc finger CCHC-type containing 2",TRUE
+"224503_s_at",0.940668681806864,0.734347390919833,-0.343652416387686,-5.88232592127341,-0.265721137011579,"ZCCHC2","zinc finger CCHC-type containing 2",TRUE
+"212423_at",0.708894565317004,0.181169828951207,-1.38060621379199,-5.05164291389872,-0.862857480620205,"ZCCHC24","zinc finger CCHC-type containing 24",TRUE
+"212419_at",0.910888708415045,0.628310099327919,-0.490920153985717,-5.82297684615244,-0.273739759962239,"ZCCHC24","zinc finger CCHC-type containing 24",TRUE
+"225072_at",0.757685936631556,0.253827858666298,-1.17153635630531,-5.2924255893018,-0.818466199014035,"ZCCHC3","zinc finger CCHC-type containing 3",TRUE
+"229993_at",0.831875452294783,0.407650191863034,-0.844072657043362,-5.5985040629973,-0.416039212018544,"ZCCHC3","zinc finger CCHC-type containing 3",TRUE
+"225091_at",0.922400451868516,0.668471982106104,-0.434018491856879,-5.84834855573468,-0.15611086383778,"ZCCHC3","zinc finger CCHC-type containing 3",TRUE
+"220473_s_at",0.775341201891078,0.291768603350403,1.0799770074473,-5.38702383525989,0.501334642215983,"ZCCHC4","zinc finger CCHC-type containing 4",TRUE
+"219917_at",0.89316156038085,0.566808823238052,0.581445954327491,-5.77634554675404,0.168004531558477,"ZCCHC4","zinc finger CCHC-type containing 4",TRUE
+"220472_at",0.957208446914964,0.806345280833865,0.248095655458773,-5.90974842461132,0.170949146657233,"ZCCHC4","zinc finger CCHC-type containing 4",TRUE
+"1552935_at",0.886782011834068,0.549910271810409,0.607170140680334,-5.76170266411485,0.188360750042944,"ZCCHC5","zinc finger CCHC-type containing 5",TRUE
+"236243_at",0.631294544151106,0.102285912689322,1.70442908234358,-4.61586762373196,0.49405187777669,"ZCCHC6","zinc finger CCHC-type containing 6",TRUE
+"238800_s_at",0.818268955967428,0.371334495557443,0.912487384338795,-5.54207709149444,0.350852191208504,"ZCCHC6","zinc finger CCHC-type containing 6",TRUE
+"220933_s_at",0.943464796017993,0.747019625138381,-0.326621339817272,-5.8878560160711,-0.130466790822368,"ZCCHC6","zinc finger CCHC-type containing 6",TRUE
+"236155_at",0.971867994936839,0.865293455829338,0.171620792785814,-5.92534784502329,0.0565262830183011,"ZCCHC6","zinc finger CCHC-type containing 6",TRUE
+"242776_at",0.975398143273847,0.881983987048062,0.150176635503951,-5.92870470166333,0.0641447010678498,"ZCCHC6","zinc finger CCHC-type containing 6",TRUE
+"226496_at",0.707818577910656,0.179426933283274,-1.38637214375601,-5.0445318500379,-0.414959941882401,"ZCCHC7","zinc finger CCHC-type containing 7",TRUE
+"230332_at",0.865561991774564,0.495464698380664,0.693073771963516,-5.70839180727045,0.33884605100344,"ZCCHC7","zinc finger CCHC-type containing 7",TRUE
+"1555562_a_at",0.953983577550391,0.788013284052788,-0.272167655410384,-5.90366843032687,-0.096776262431181,"ZCCHC7","zinc finger CCHC-type containing 7",TRUE
+"230786_at",0.808233282592165,0.350275841754992,-0.954203602533219,-5.50568157931948,-0.46296109768705,"ZCCHC8","zinc finger CCHC-type containing 8",TRUE
+"218478_s_at",0.942303845415102,0.740396762365808,-0.335509639833831,-5.88500461390527,-0.0968353858256101,"ZCCHC8","zinc finger CCHC-type containing 8",TRUE
+"225538_at",0.973071267819624,0.870453577582133,-0.164982696288118,-5.9264346575377,-0.0573185981797959,"ZCCHC9","zinc finger CCHC-type containing 9",TRUE
+"227416_s_at",0.805746717966166,0.345837367378683,-0.963210470718257,-5.49762778784737,-0.250684686175086,"ZCRB1","zinc finger CCHC-type and RNA binding motif containing 1",TRUE
+"225394_s_at",0.811026626942307,0.355027184073839,-0.944647172843114,-5.51415100738916,-0.310227836078722,"ZCRB1","zinc finger CCHC-type and RNA binding motif containing 1",TRUE
+"223992_x_at",0.687949239097856,0.157312178343179,1.46372751681699,-4.9467790666499,0.788294864243206,"ZCWPW1","zinc finger CW-type and PWWP domain containing 1",TRUE
+"220618_s_at",0.807944276806637,0.349549564345736,0.955672091318118,-5.50437320466254,0.597673439095403,"ZCWPW1","zinc finger CW-type and PWWP domain containing 1",TRUE
+"243863_at",0.82979599608837,0.401310307573212,0.855723445418101,-5.58918347090111,0.82385422696658,"ZCWPW2","zinc finger CW-type and PWWP domain containing 2",TRUE
+"228749_at",0.763391321581193,0.263124449389207,1.14821874058753,-5.31716112388782,1.10728025692184,"ZDBF2","zinc finger DBF-type containing 2",TRUE
+"228637_at",0.856257656023992,0.469936112081796,-0.735187824948081,-5.67979946041654,-0.760621508626063,"ZDHHC1","zinc finger DHHC-type containing 1",TRUE
+"237228_at",0.925819519240262,0.678822644429943,0.419593939924585,-5.8542935132589,0.195446823616509,"ZDHHC1","zinc finger DHHC-type containing 1",TRUE
+"232417_x_at",0.790615408732319,0.320323960388447,1.01658472441299,-5.44848875844415,1.03864281684001,"ZDHHC11","zinc finger DHHC-type containing 11",TRUE
+"1552283_s_at",0.946999149987826,0.759331371476292,0.310168642164105,-5.89293409789367,0.287497093146682,"ZDHHC11B///ZDHHC11","zinc finger DHHC-type containing 11B///zinc finger DHHC-type containing 11",TRUE
+"221646_s_at",0.950656555227597,0.775026342802285,0.289320101478255,-5.89899535278628,0.301798165122335,"ZDHHC11B///ZDHHC11","zinc finger DHHC-type containing 11B///zinc finger DHHC-type containing 11",TRUE
+"226088_at",0.861665593344139,0.483813774403922,0.712133878430574,-5.69565024862364,0.317952003806301,"ZDHHC12","zinc finger DHHC-type containing 12",TRUE
+"232440_at",0.429170076412192,0.0187380724099002,2.53664398855857,-3.21387522984644,0.993842759445712,"ZDHHC13","zinc finger DHHC-type containing 13",TRUE
+"219296_at",0.562638706929609,0.0551782120998,2.02413080414423,-4.11972712943929,0.721395176836239,"ZDHHC13","zinc finger DHHC-type containing 13",TRUE
+"219247_s_at",0.68747436517451,0.156133855049933,1.46808950422272,-4.94113810223653,1.12800613466708,"ZDHHC14","zinc finger DHHC-type containing 14",TRUE
+"235133_at",0.805746717966166,0.345709381532172,0.963471351730331,-5.49739348147371,0.844837795540652,"ZDHHC14","zinc finger DHHC-type containing 14",TRUE
+"239281_at",0.841550580403629,0.433149519312563,0.798336209337953,-5.6339364469568,0.568698559269252,"ZDHHC14","zinc finger DHHC-type containing 14",TRUE
+"1556967_at",0.961362864777978,0.824577151842319,0.224302870800995,-5.91520813575942,0.167014642010264,"ZDHHC14","zinc finger DHHC-type containing 14",TRUE
+"1552557_a_at",0.802255823093278,0.339971766958582,-0.975235007061782,-5.48676793388239,-0.845309010784965,"ZDHHC15","zinc finger DHHC-type containing 15",TRUE
+"223212_at",0.997275650300134,0.986117297981267,0.0175977011813523,-5.93953264860925,0.0070663399866504,"ZDHHC16","zinc finger DHHC-type containing 16",TRUE
+"216871_at",0.721907781985393,0.198164623032147,1.32656319757106,-5.11708988454599,0.449071864731492,"ZDHHC17","zinc finger DHHC-type containing 17",TRUE
+"217486_s_at",0.723649742218726,0.200358661137761,-1.31985444942346,-5.12506118461556,-0.938090466529414,"ZDHHC17","zinc finger DHHC-type containing 17",TRUE
+"212982_at",0.892780783477555,0.566052735497073,-0.582588375243143,-5.77570825710665,-0.231629750536385,"ZDHHC17","zinc finger DHHC-type containing 17",TRUE
+"231908_at",0.314126572995991,0.00667602729931853,2.99252372707977,-2.32305730736713,1.33990180951,"ZDHHC18","zinc finger DHHC-type containing 18",TRUE
+"1558327_at",0.933609099853387,0.706140530199054,-0.381945462444726,-5.86887828182035,-0.114413734609543,"ZDHHC18","zinc finger DHHC-type containing 18",TRUE
+"212860_at",0.937113154905832,0.719403614406606,0.363870847695074,-5.87540030223365,0.111495873404419,"ZDHHC18","zinc finger DHHC-type containing 18",TRUE
+"231900_at",0.991059530537351,0.958253041689401,0.0529413886028613,-5.93831843697354,0.018506641404791,"ZDHHC18","zinc finger DHHC-type containing 18",TRUE
+"1553952_at",0.88166256834198,0.538545209791706,0.624705070536305,-5.75137085680878,0.371494894209554,"ZDHHC19","zinc finger DHHC-type containing 19",TRUE
+"231122_x_at",0.957868442073393,0.810484445265716,-0.242681646639698,-5.9110388404043,-0.0910962038053134,"ZDHHC19","zinc finger DHHC-type containing 19",TRUE
+"222730_s_at",0.64790483160958,0.119291335580214,1.62040685521348,-4.7358198233241,1.27066508822115,"ZDHHC2","zinc finger DHHC-type containing 2",TRUE
+"222731_at",0.65284137151906,0.121823777237493,1.60877019116226,-4.7520655419024,2.47506382187413,"ZDHHC2","zinc finger DHHC-type containing 2",TRUE
+"1563502_at",0.80110325033185,0.337659268080746,-0.980014672627538,-5.4824170932698,-0.623832237348952,"ZDHHC2","zinc finger DHHC-type containing 2",TRUE
+"244779_at",0.813065886130395,0.362597804547867,0.929596820252534,-5.52733078094812,1.32919403454767,"ZDHHC2","zinc finger DHHC-type containing 2",TRUE
+"225365_at",0.673190784310977,0.138778559621659,-1.53566422293265,-4.85202998707688,-0.632406047585871,"ZDHHC20","zinc finger DHHC-type containing 20",TRUE
+"243786_at",0.96351240321323,0.833724493288792,-0.212416059797254,-5.91773077309564,-0.0689703309059873,"ZDHHC20","zinc finger DHHC-type containing 20",TRUE
+"243550_at",0.664094349733756,0.132093946826946,-1.56355271169475,-4.81432615201568,-1.27564741746724,"ZDHHC21","zinc finger DHHC-type containing 21",TRUE
+"241946_at",0.73957587762701,0.228223579466354,-1.23923989634655,-5.21815485746795,-0.732589242352981,"ZDHHC21","zinc finger DHHC-type containing 21",TRUE
+"233216_at",0.77547560202111,0.292464106039182,-1.07838166201133,-5.38861153130808,-0.990905093451373,"ZDHHC21","zinc finger DHHC-type containing 21",TRUE
+"229923_at",0.843095426822889,0.437286835058489,0.791075096872724,-5.63939123994438,0.279624136440374,"ZDHHC21","zinc finger DHHC-type containing 21",TRUE
+"235068_at",0.919177722942441,0.655907066494729,-0.451655802008488,-5.84081149428833,-0.257583944119154,"ZDHHC21","zinc finger DHHC-type containing 21",TRUE
+"243835_at",0.948668195792872,0.766415505651202,0.300741562276289,-5.89572657838369,0.136349162715559,"ZDHHC21","zinc finger DHHC-type containing 21",TRUE
+"233247_x_at",0.960506476261889,0.820580841448429,0.229506294714902,-5.91406085150744,0.141159295847984,"ZDHHC21","zinc finger DHHC-type containing 21",TRUE
+"229240_at",0.966769992359004,0.845335744380241,-0.197372167744635,-5.92072735229338,-0.083881144746365,"ZDHHC21","zinc finger DHHC-type containing 21",TRUE
+"233215_s_at",0.991689960875868,0.960986001452836,0.0494725265346006,-5.93849144900589,0.0380805645848108,"ZDHHC21","zinc finger DHHC-type containing 21",TRUE
+"229805_at",0.726432421917557,0.20529387044186,-1.30497071157965,-5.14262406705434,-0.418760625688149,"ZDHHC22","zinc finger DHHC-type containing 22",TRUE
+"229875_at",0.836752569023453,0.418567585967836,-0.824276945200439,-5.61406681509151,-0.833252315696471,"ZDHHC22","zinc finger DHHC-type containing 22",TRUE
+"226912_at",0.997470525710394,0.987245861692916,-0.0161669987550448,-5.93955617696009,-0.00631608123715921,"ZDHHC23","zinc finger DHHC-type containing 23",TRUE
+"232091_s_at",0.819018525257656,0.374942065740026,0.90550053231358,-5.54802627870636,0.50080882637088,"ZDHHC24","zinc finger DHHC-type containing 24",TRUE
+"205634_x_at",0.927432565450488,0.682118806665943,-0.41501953412082,-5.85613756595036,-0.154472699910205,"ZDHHC24","zinc finger DHHC-type containing 24",TRUE
+"227549_x_at",0.952041062962677,0.780597798642957,-0.28195107251983,-5.9010377144715,-0.13028403419637,"ZDHHC24","zinc finger DHHC-type containing 24",TRUE
+"236507_at",0.604682600348682,0.0787543028322992,1.84296537577535,-4.40830292691341,0.497210409867916,"ZDHHC3","zinc finger DHHC-type containing 3",TRUE
+"218077_s_at",0.805654356268614,0.345006036245305,0.964906197032127,-5.49610376022747,0.337096488987267,"ZDHHC3","zinc finger DHHC-type containing 3",TRUE
+"226171_at",0.821600429533552,0.384238678194964,0.887697533180292,-5.56299408221982,0.394849685882579,"ZDHHC3","zinc finger DHHC-type containing 3",TRUE
+"218078_s_at",0.981587171772385,0.912659619528956,0.110943987429897,-5.93369020857436,0.0411203727877165,"ZDHHC3","zinc finger DHHC-type containing 3",TRUE
+"220261_s_at",0.769847953580141,0.278238460856256,1.11157282206243,-5.3551491597876,1.3805506646961,"ZDHHC4","zinc finger DHHC-type containing 4",TRUE
+"223137_at",0.777792695650153,0.296763299935214,1.06858006294287,-5.39832008611295,0.555912082585662,"ZDHHC4","zinc finger DHHC-type containing 4",TRUE
+"224868_at",0.869487815945782,0.506754614050718,0.674846844905724,-5.72026757069008,0.225474629443283,"ZDHHC5","zinc finger DHHC-type containing 5",TRUE
+"224858_at",0.958723944343516,0.812866742078581,-0.239568982015819,-5.91176791973339,-0.0622294607309009,"ZDHHC5","zinc finger DHHC-type containing 5",TRUE
+"218249_at",0.880203017022901,0.535652216746848,0.629200076785058,-5.74867671765685,0.20643618546457,"ZDHHC6","zinc finger DHHC-type containing 6",TRUE
+"218606_at",0.769847953580141,0.278061049863897,-1.11199443631751,-5.3547183043596,-0.3900566204664,"ZDHHC7","zinc finger DHHC-type containing 7",TRUE
+"230731_x_at",0.71789173952175,0.19357016589911,1.34080217059421,-5.10005858846758,0.903684454053684,"ZDHHC8","zinc finger DHHC-type containing 8",TRUE
+"225744_at",0.79279559916191,0.324643816545697,1.00734566441913,-5.45716684281692,1.45191037844547,"ZDHHC8","zinc finger DHHC-type containing 8",TRUE
+"222274_at",0.734861913384601,0.219837459353767,-1.26266485850662,-5.19162010007104,-1.01110534432298,"ZDHHC8P1","zinc finger DHHC-type containing 8 pseudogene 1",TRUE
+"222451_s_at",0.704906176852943,0.176732581112028,-1.39537393854318,-5.03338096671464,-0.591039722478634,"ZDHHC9","zinc finger DHHC-type containing 9",TRUE
+"235015_at",0.885312914741353,0.546453434856728,-0.612483099983774,-5.75860214682847,-0.227393534310001,"ZDHHC9","zinc finger DHHC-type containing 9",TRUE
+"239952_at",0.687734660055697,0.156900283786831,-1.46524927389916,-4.9448126601866,-1.0894628068142,"ZEB1","zinc finger E-box binding homeobox 1",TRUE
+"212758_s_at",0.830592576740524,0.403130667126808,0.852366197582037,-5.59188147455587,0.886661729025297,"ZEB1","zinc finger E-box binding homeobox 1",TRUE
+"210875_s_at",0.937612755058333,0.723286569183271,-0.358602804942139,-5.87724248372415,-0.527561886070438,"ZEB1","zinc finger E-box binding homeobox 1",TRUE
+"212764_at",0.954577684533304,0.792710540482899,-0.265984529243576,-5.90528347684371,-0.370964874894497,"ZEB1","zinc finger E-box binding homeobox 1",TRUE
+"229090_at",0.746535697909741,0.23845073510658,-1.2115427285235,-5.24897601232295,-0.454408413704908,"ZEB1-AS1","ZEB1 antisense RNA 1",TRUE
+"235593_at",0.841550580403629,0.432966607319251,0.7986582117642,-5.63369346250898,0.698665509770398,"ZEB2","zinc finger E-box binding homeobox 2",TRUE
+"228333_at",0.893176496495633,0.567744964960389,-0.58003255980124,-5.77713232107191,-0.556644361608613,"ZEB2","zinc finger E-box binding homeobox 2",TRUE
+"203603_s_at",0.924804503175258,0.674553334917774,0.425532456431308,-5.85186991249472,0.448026903388392,"ZEB2","zinc finger E-box binding homeobox 2",TRUE
+"233031_at",0.934200936091995,0.708742385733138,0.378389677128497,-5.87018598653862,0.286789262832027,"ZEB2","zinc finger E-box binding homeobox 2",TRUE
+"233033_at",0.973433731874338,0.871674541255936,-0.163413142128825,-5.92668538110216,-0.0536504687559325,"ZEB2","zinc finger E-box binding homeobox 2",TRUE
+"202456_s_at",0.144614324102004,0.000991867792194811,-3.79147949063271,-0.649376156071976,-2.46619506363441,"ZER1","zyg-11 related cell cycle regulator",TRUE
+"202452_at",0.647518308302168,0.118724452752182,-1.62303998629357,-4.73213121038123,-0.549574038988558,"ZER1","zyg-11 related cell cycle regulator",TRUE
+"202448_s_at",0.838999550222784,0.424632749040053,-0.813419796762193,-5.62245550636503,-0.271190052427825,"ZER1","zyg-11 related cell cycle regulator",TRUE
+"230358_at",0.990797621966014,0.953361489038759,-0.0591517777142278,-5.93797942327027,-0.016163346959881,"ZER1","zyg-11 related cell cycle regulator",TRUE
+"218919_at",0.941311073534434,0.737409084059266,0.339528288505702,-5.88369055597752,0.10268803663665,"ZFAND1","zinc finger AN1-type containing 1",TRUE
+"226650_at",0.415590231477955,0.0168853363612724,2.58382546397338,-3.12485933237067,0.823461968761306,"ZFAND2A","zinc finger AN1-type containing 2A",TRUE
+"226168_at",0.662946889292072,0.130921725101262,-1.56856297128114,-4.80749590262649,-0.5116173678247,"ZFAND2B","zinc finger AN1-type containing 2B",TRUE
+"218020_s_at",0.895690630367785,0.575761843804085,-0.567976925074104,-5.78376777956621,-0.172940603483674,"ZFAND3","zinc finger AN1-type containing 3",TRUE
+"222493_s_at",0.960344430556183,0.820124150108764,0.230101342844401,-5.91392798351429,0.0768588459464272,"ZFAND3","zinc finger AN1-type containing 3",TRUE
+"223624_at",0.908375053779996,0.619227736338688,0.504012325937414,-5.81670729493935,0.45593074493417,"ZFAND4","zinc finger AN1-type containing 4",TRUE
+"244206_at",0.935316549043744,0.712295049685024,-0.373542484389796,-5.87194919673866,-0.278071442485045,"ZFAND4","zinc finger AN1-type containing 4",TRUE
+"228317_at",0.818999571709518,0.37299432401599,0.909267207493762,-5.54482426168441,0.594787120336121,"ZFAND5","zinc finger AN1-type containing 5",TRUE
+"210275_s_at",0.831875452294783,0.406903248693344,-0.845439269812548,-5.59741694729675,-0.317993792288643,"ZFAND5","zinc finger AN1-type containing 5",TRUE
+"217741_s_at",0.839519981963042,0.426409304093668,-0.810258007317853,-5.62487882758364,-0.29491665825311,"ZFAND5","zinc finger AN1-type containing 5",TRUE
+"229368_s_at",0.963120895816356,0.83242111664974,0.214107823277738,-5.91738008814423,0.059065992736766,"ZFAND5","zinc finger AN1-type containing 5",TRUE
+"217649_at",0.968917934155285,0.853178883825936,-0.18723688032898,-5.9226226035073,-0.0795826212095889,"ZFAND5","zinc finger AN1-type containing 5",TRUE
+"221613_s_at",0.757950630724418,0.254491163229819,-1.1698518666351,-5.29422711418161,-0.393842979277084,"ZFAND6","zinc finger AN1-type containing 6",TRUE
+"239757_at",0.966064677476069,0.841912904113759,-0.201801903680519,-5.91986776068119,-0.202697357840075,"ZFAND6","zinc finger AN1-type containing 6",TRUE
+"229899_s_at",0.908667507590078,0.619966529592884,0.502944048915643,-5.81722490405514,0.219997267830003,"ZFAS1","ZNFX1 antisense RNA 1",TRUE
+"226227_x_at",0.968532482108794,0.852344012970219,0.188314768220804,-5.92242577364495,0.0678934794639723,"ZFAS1","ZNFX1 antisense RNA 1",TRUE
+"224915_x_at",0.978316880841318,0.895795190621802,0.132486670576337,-5.93113781356707,0.048576852448754,"ZFAS1","ZNFX1 antisense RNA 1",TRUE
+"226835_s_at",0.980001024522674,0.904863931720177,-0.120894912054827,-5.93256727702555,-0.0501617886731864,"ZFAS1","ZNFX1 antisense RNA 1",TRUE
+"226564_at",0.874474734833648,0.520749429924658,0.652566519192447,-5.73437262114575,0.196430650973866,"ZFAT","zinc finger and AT-hook domain containing",TRUE
+"213065_at",0.919354071504066,0.656279941949806,0.451130326024986,-5.84104030491989,0.124924356758866,"ZFC3H1","zinc finger C3H1-type containing",TRUE
+"1553736_at",0.929810116186681,0.690312798102419,-0.403686596532816,-5.86062047443149,-0.210029899390854,"ZFC3H1","zinc finger C3H1-type containing",TRUE
+"231946_at",0.889452275006221,0.557556497051102,-0.59548033804682,-5.76843273416086,-0.423048936430425,"ZFHX2","zinc finger homeobox 2",TRUE
+"207699_at",0.906476756086155,0.613814757340195,-0.511857623822903,-5.81287321402745,-0.158516908476697,"ZFHX2","zinc finger homeobox 2",TRUE
+"233751_at",0.709135917979769,0.181681900445236,1.3789205229504,-5.05371721377291,0.574806027967331,"ZFHX3","zinc finger homeobox 3",TRUE
+"242738_s_at",0.821424121108148,0.383486272744517,-0.889127804571166,-5.56180175009293,-0.32962177071462,"ZFHX3","zinc finger homeobox 3",TRUE
+"208033_s_at",0.863835356219448,0.48979072976155,-0.702323403984137,-5.70224964535324,-0.30623814864462,"ZFHX3","zinc finger homeobox 3",TRUE
+"226137_at",0.884729701742031,0.544035533565557,-0.616209854996189,-5.75641175622267,-0.223437598865996,"ZFHX3","zinc finger homeobox 3",TRUE
+"233752_s_at",0.930499673921727,0.692493858244211,-0.400679121878032,-5.86178961420567,-0.220949679307984,"ZFHX3","zinc finger homeobox 3",TRUE
+"243323_s_at",0.986280597793838,0.932721973235036,-0.0853852694038288,-5.93613310052464,-0.062212581723518,"ZFHX3","zinc finger homeobox 3",TRUE
+"241700_at",0.634202341398092,0.105314627690879,1.68864061536728,-4.63875836769994,1.10271062713404,"ZFHX4","zinc finger homeobox 4",TRUE
+"219779_at",0.704449222279154,0.176422301372802,1.39641757748279,-5.03208430855034,1.19364082792266,"ZFHX4","zinc finger homeobox 4",TRUE
+"1559270_at",0.774230543658252,0.28749876839748,1.08983156540377,-5.37717011905424,0.797297688280635,"ZFHX4","zinc finger homeobox 4",TRUE
+"1559965_at",0.744931128252932,0.236655687733977,1.2163381182053,-5.24368287134938,1.43923779443947,"ZFHX4-AS1","ZFHX4 antisense RNA 1",TRUE
+"1559966_a_at",0.899155703544461,0.58941573656324,-0.547637283434392,-5.79465632726753,-0.362223761073547,"ZFHX4-AS1","ZFHX4 antisense RNA 1",TRUE
+"226807_at",0.626252720246384,0.0970620128279444,-1.73262066570443,-4.57459801005297,-0.664206770112795,"ZFP1","ZFP1 zinc finger protein",TRUE
+"234455_at",0.940044918888428,0.731150620352927,0.347964990218698,-5.88088151039407,0.324959885713497,"ZFP1","ZFP1 zinc finger protein",TRUE
+"234810_at",0.983498417373669,0.919440385955712,-0.102297932774618,-5.93458771490603,-0.0762921338894893,"ZFP1","ZFP1 zinc finger protein",TRUE
+"232911_at",0.952952008650351,0.784489953719326,-0.27681262179425,-5.90243091720232,-0.190902524146054,"ZFP14","ZFP14 zinc finger protein",TRUE
+"207757_at",0.876632890672003,0.525555255215376,-0.644991973074917,-5.73906437730845,-0.649373337222301,"ZFP2","ZFP2 zinc finger protein",TRUE
+"240565_at",0.869784729509912,0.507513288642354,0.673630267272183,-5.72104945651127,0.35600418858302,"ZFP28","ZFP28 zinc finger protein",TRUE
+"234300_s_at",0.946727564264032,0.758557101419928,0.31120071306697,-5.89262319252361,0.170404748378965,"ZFP28","ZFP28 zinc finger protein",TRUE
+"231943_at",0.993474831312851,0.969480189185366,0.0386948887858329,-5.93895423015652,0.0204955445718848,"ZFP28","ZFP28 zinc finger protein",TRUE
+"234937_x_at",0.997589781442354,0.9877443291637,-0.0155350929256087,-5.93956593404925,-0.0095239854730611,"ZFP28","ZFP28 zinc finger protein",TRUE
+"235728_at",0.731314021977412,0.214443883648133,-1.27809502545949,-5.17390921261178,-1.2875099338683,"ZFP3","ZFP3 zinc finger protein",TRUE
+"207090_x_at",0.0681210092794308,0.000183726059733871,-4.48059750236847,0.837252685319417,-1.91852368137887,"ZFP30","ZFP30 zinc finger protein",TRUE
+"201531_at",0.859122424227944,0.475971290664691,-0.725113704428318,-5.68678498699784,-0.522644635843253,"ZFP36","ZFP36 ring finger protein",TRUE
+"213277_at",0.786455312223125,0.311967381970419,-1.03470770993603,-5.43125826444635,-0.737641414842731,"ZFP36L1","ZFP36 ring finger protein like 1",TRUE
+"213284_at",0.854040699678541,0.463253879803511,-0.746431601755373,-5.6718949061852,-0.572273027961932,"ZFP36L1","ZFP36 ring finger protein like 1",TRUE
+"211965_at",0.872005986651814,0.514686880571389,0.662176957506242,-5.72834417805526,0.463515642798615,"ZFP36L1","ZFP36 ring finger protein like 1",TRUE
+"211962_s_at",0.878942349297988,0.532526918772419,0.63407074406129,-5.74573643816441,0.26634377412481,"ZFP36L1","ZFP36 ring finger protein like 1",TRUE
+"201367_s_at",0.760439386481756,0.259198657642243,1.15798972107796,-5.30684909421798,0.851995786039019,"ZFP36L2","ZFP36 ring finger protein like 2",TRUE
+"201369_s_at",0.805859691692007,0.346164846227554,0.962543250693858,-5.49822677768067,0.573710070044086,"ZFP36L2","ZFP36 ring finger protein like 2",TRUE
+"201368_at",0.888830748858811,0.556096259116769,0.597706292695515,-5.76716094473801,0.383117378926498,"ZFP36L2","ZFP36 ring finger protein like 2",TRUE
+"227681_at",0.952143625584695,0.781027699384508,0.281383136052287,-5.9011929507445,0.103031355604712,"ZFP36L2","ZFP36 ring finger protein like 2",TRUE
+"207068_at",0.806649582904638,0.347593085949876,-0.959638303017929,-5.50083024142304,-0.863624574935832,"ZFP37","ZFP37 zinc finger protein",TRUE
+"237362_at",0.61760967235709,0.0879391794863797,-1.78512610326726,-4.4964025855997,-0.825578272935869,"ZFP41","ZFP41 zinc finger protein",TRUE
+"227902_at",0.845588139978284,0.443022971169369,0.781077553003778,-5.64682493577399,0.614557942263141,"ZFP41","ZFP41 zinc finger protein",TRUE
+"227898_s_at",0.985709215004606,0.930977413994843,-0.0876052129499883,-5.93594612154344,-0.047446328707883,"ZFP41","ZFP41 zinc finger protein",TRUE
+"227023_at",0.856528422017685,0.470454837977743,0.734318968184909,-5.6804055429291,0.457823324975183,"ZFP41///GLI4","ZFP41 zinc finger protein///GLI family zinc finger 4",TRUE
+"1554777_at",0.407748633394319,0.0156340002906301,2.61852083572854,-3.05888122338012,2.27037037945597,"ZFP42","ZFP42 zinc finger protein",TRUE
+"1554776_at",0.505411134618713,0.0330002960689908,2.27398115238614,-3.69314839644191,2.17515911116349,"ZFP42","ZFP42 zinc finger protein",TRUE
+"243161_x_at",0.69866353626144,0.169979364016545,1.41842695645675,-5.00455293843798,1.66980052199766,"ZFP42","ZFP42 zinc finger protein",TRUE
+"231236_at",0.00102963252639748,1.31823094371876e-07,7.59571105123335,7.01808280401561,3.25468735590188,"ZFP57","ZFP57 zinc finger protein",TRUE
+"227796_at",0.801560848966415,0.338543309931458,-0.97818481768917,-5.48408506648086,-0.478565104122591,"ZFP62","ZFP62 zinc finger protein",TRUE
+"222897_s_at",0.517654151778308,0.036775548720711,2.22234116026789,-3.78382669676632,1.35564656010582,"ZFP64","ZFP64 zinc finger protein",TRUE
+"219536_s_at",0.5897618614591,0.067979779868751,1.91882548204336,-4.28973917047245,0.916490365959218,"ZFP64","ZFP64 zinc finger protein",TRUE
+"229186_s_at",0.739189560382301,0.226075394425565,1.24517696786766,-5.211469991761,0.448615754539332,"ZFP64","ZFP64 zinc finger protein",TRUE
+"218968_s_at",0.778397054392363,0.298273831172706,-1.06516037322031,-5.40168864788078,-0.36741114583727,"ZFP64","ZFP64 zinc finger protein",TRUE
+"1569107_s_at",0.978255630670068,0.894883091404021,-0.133653527815197,-5.93098668626771,-0.149166279574134,"ZFP69","ZFP69 zinc finger protein",TRUE
+"235939_at",0.156242460469172,0.00118920722695409,-3.71681107356322,-0.809359504846652,-1.36835296471769,"ZFP69B","ZFP69 zinc finger protein B",TRUE
+"207219_at",0.826134344333512,0.393930671033219,0.869434776368618,-5.57806208838407,0.565858438077638,"ZFP69B","ZFP69 zinc finger protein B",TRUE
+"1555793_a_at",0.871592576046691,0.513006073079422,0.664852494783052,-5.72665083023237,0.915216211652603,"ZFP82","ZFP82 zinc finger protein",TRUE
+"235176_at",0.998038817582822,0.990743504445976,-0.011733174283818,-5.93961642826708,-0.00904162348732651,"ZFP82","ZFP82 zinc finger protein",TRUE
+"242400_at",0.725583196024696,0.204721162224724,-1.30668352798991,-5.14061151370193,-0.425465066806306,"ZFP90","ZFP90 zinc finger protein",TRUE
+"226124_at",0.773234064853267,0.284517398128617,-1.0967751415627,-5.37017925369204,-0.477561022986565,"ZFP90","ZFP90 zinc finger protein",TRUE
+"235698_at",0.807944276806637,0.349666712980912,-0.955435084005833,-5.50458449492272,-0.479836600698636,"ZFP90","ZFP90 zinc finger protein",TRUE
+"224636_at",0.821424121108148,0.383070545955346,-0.889918860598271,-5.5611415301326,-0.269487111367996,"ZFP91","ZFP91 zinc finger protein",TRUE
+"224631_at",0.937113154905832,0.72043671248149,-0.362468214967328,-5.87589338005405,-0.171012041128705,"ZFP91","ZFP91 zinc finger protein",TRUE
+"233116_at",0.971987285195444,0.86576645247404,0.171011995191694,-5.92544929994642,0.0731951575061691,"ZFP92","ZFP92 zinc finger protein",TRUE
+"214311_at",0.593339168375633,0.0704602019787824,-1.90047515826764,-4.31872659398951,-1.2244364305037,"ZFPL1","zinc finger protein like 1",TRUE
+"214310_s_at",0.891653456393983,0.561539998876508,-0.58942333166829,-5.77187015726458,-0.190894749061835,"ZFPL1","zinc finger protein like 1",TRUE
+"209428_s_at",0.976335130930535,0.885764087783215,-0.145330289779319,-5.92940150531585,-0.0503326110088924,"ZFPL1","zinc finger protein like 1",TRUE
+"237463_at",0.555096042605915,0.0513380273584849,2.0599703434431,-4.06048491192258,0.660184238984522,"ZFPM1","zinc finger protein, FOG family member 1",TRUE
+"242282_at",0.737161440695888,0.223325710750939,-1.25283956362467,-5.20280168450793,-0.455648163467943,"ZFPM1","zinc finger protein, FOG family member 1",TRUE
+"219778_at",0.942199057522921,0.739836107942998,0.336263330236489,-5.8847593437037,0.441951537985177,"ZFPM2","zinc finger protein, FOG family member 2",TRUE
+"213286_at",0.689950875648652,0.159298132594574,1.45643529496215,-4.95617903084281,0.476397791755565,"ZFR","zinc finger RNA binding protein",TRUE
+"201857_at",0.731631029652938,0.215401274518945,1.27533445964241,-5.17709130657604,0.326230479679783,"ZFR","zinc finger RNA binding protein",TRUE
+"201856_s_at",0.812486825020947,0.361030954071951,0.93269427237087,-5.52463419823673,0.304047815251721,"ZFR","zinc finger RNA binding protein",TRUE
+"33148_at",0.830592576740524,0.403227147111632,0.852188533048329,-5.59202397671923,0.293553717241524,"ZFR","zinc finger RNA binding protein",TRUE
+"233064_at",0.89390639630277,0.569621428292832,0.577203044077643,-5.7787018170911,0.513500163263067,"ZFR2","zinc finger RNA binding protein 2",TRUE
+"215419_at",0.956762870061999,0.804291666323409,0.250784579551402,-5.90909700723259,0.175001991344816,"ZFR2","zinc finger RNA binding protein 2",TRUE
+"214678_x_at",0.471793372004737,0.0257505141577096,-2.39049181563784,-3.48412917015961,-0.911899561241512,"ZFX","zinc finger protein, X-linked",TRUE
+"229022_at",0.740258721846281,0.228637385200149,-1.2381011293408,-5.21943391259417,-0.377672070533041,"ZFX","zinc finger protein, X-linked",TRUE
+"217176_s_at",0.928596293858875,0.686175464534056,0.409402039090836,-5.85837491158054,0.206555775281062,"ZFX","zinc finger protein, X-linked",TRUE
+"207920_x_at",0.957017346544368,0.805325908074869,0.249430148120425,-5.90942600357306,0.106642334558565,"ZFX","zinc finger protein, X-linked",TRUE
+"230760_at",0.775341201891078,0.29173391212436,1.08005665372168,-5.38694451594815,1.03234617098905,"ZFY","zinc finger protein, Y-linked",TRUE
+"207246_at",0.97689149311934,0.890068105602864,0.139816575905339,-5.93016652499495,0.117132335167634,"ZFY","zinc finger protein, Y-linked",TRUE
+"207247_s_at",0.9855380892974,0.930324331871014,-0.0884363723600583,-5.93587488174253,-0.039560054183319,"ZFY///ZFX","zinc finger protein, Y-linked///zinc finger protein, X-linked",TRUE
+"223387_at",0.70573152022539,0.178114115182262,-1.39074472051529,-5.03912282429178,-0.473314377076333,"ZFYVE1","zinc finger FYVE-type containing 1",TRUE
+"223388_s_at",0.721499527275875,0.197797099484922,-1.32769264837111,-5.11574452867803,-0.422724157751446,"ZFYVE1","zinc finger FYVE-type containing 1",TRUE
+"1555011_at",0.668518995965071,0.13478673510778,-1.55218117987934,-4.82976457928599,-1.15625009306285,"ZFYVE16","zinc finger FYVE-type containing 16",TRUE
+"203651_at",0.730048787941067,0.21254433949965,-1.28360046462323,-5.16754560430325,-0.447732876425254,"ZFYVE16","zinc finger FYVE-type containing 16",TRUE
+"1554638_at",0.740476003158683,0.229084537204581,-1.23687235717352,-5.22081292486187,-0.540497443184226,"ZFYVE16","zinc finger FYVE-type containing 16",TRUE
+"240859_at",0.964685626382167,0.836699696267818,0.208556656668915,-5.91852041963139,0.141137079474031,"ZFYVE16","zinc finger FYVE-type containing 16",TRUE
+"1555982_at",0.990918916504081,0.957219911232362,-0.0542528804873575,-5.93824997296973,-0.0226297977649832,"ZFYVE16","zinc finger FYVE-type containing 16",TRUE
+"225843_at",0.854184492233394,0.46431013198506,-0.744647933314591,-5.67315644393745,-0.392239267938841,"ZFYVE19","zinc finger FYVE-type containing 19",TRUE
+"219929_s_at",0.755049574909504,0.248925648232499,-1.18408849380369,-5.27893002820848,-0.490865979928186,"ZFYVE21","zinc finger FYVE-type containing 21",TRUE
+"224445_s_at",0.812302873476553,0.357070501955978,-0.940563973514681,-5.51774592340656,-0.405752948695811,"ZFYVE21","zinc finger FYVE-type containing 21",TRUE
+"37943_at",0.904639751569488,0.60863599929554,-0.519394030330885,-5.80913572652922,-0.203531809532882,"ZFYVE26","zinc finger FYVE-type containing 26",TRUE
+"213073_at",0.996455602606062,0.982584192393399,-0.0220769461440961,-5.93944609308276,-0.007926965491734,"ZFYVE26","zinc finger FYVE-type containing 26",TRUE
+"225218_at",0.627092759817312,0.0989450093307148,1.72231292605207,-4.5897460932808,0.489961044128055,"ZFYVE27","zinc finger FYVE-type containing 27",TRUE
+"1569383_s_at",0.767965891104819,0.271024266054144,-1.12887773001207,-5.33734610083009,-0.747701625467063,"ZFYVE28","zinc finger FYVE-type containing 28",TRUE
+"232408_at",0.860714927752408,0.48053739792957,-0.71754147339267,-5.69197535679746,-0.742510113922951,"ZFYVE28","zinc finger FYVE-type containing 28",TRUE
+"1569369_at",0.998870448604467,0.996014978680888,-0.00505115958568927,-5.93967105372421,-0.00424474362529814,"ZFYVE28","zinc finger FYVE-type containing 28",TRUE
+"208446_s_at",0.821424121108148,0.382937204711682,-0.890172704921032,-5.56092955494113,-0.295046391723664,"ZFYVE9","zinc finger FYVE-type containing 9",TRUE
+"204893_s_at",0.966676135540784,0.845160861779909,0.197598396805431,-5.92068391300794,0.0607746080535314,"ZFYVE9","zinc finger FYVE-type containing 9",TRUE
+"214142_at",0.868397087637799,0.503792112996876,-0.679607219042926,-5.71719513886434,-0.649071776844812,"ZG16","zymogen granule protein 16",TRUE
+"228058_at",0.83872852514497,0.424119636453664,-0.814334535650558,-5.6217527629902,-0.930135281956019,"ZG16B","zymogen granule protein 16B",TRUE
+"239720_at",0.962050375516713,0.827657242610691,-0.220296741667152,-5.91607359346403,-0.127664682584251,"ZGLP1","zinc finger, GATA-like protein 1",TRUE
+"221848_at",0.676515789388387,0.143519097231201,-1.51654965368043,-4.87756084963898,-0.543860496391812,"ZGPAT","zinc finger CCCH-type and G-patch domain containing",TRUE
+"57539_at",0.768852835478002,0.273180629444541,-1.12367030768325,-5.34272902260651,-0.298085917656781,"ZGPAT///LIME1","zinc finger CCCH-type and G-patch domain containing///Lck interacting transmembrane adaptor 1",TRUE
+"228859_at",0.57460012602512,0.0605850120406112,-1.97726269412156,-4.19615369790035,-0.59588767897178,"ZGRF1","zinc finger GRF-type containing 1",TRUE
+"1565935_at",0.834881450121645,0.413576031449966,-0.833286698292172,-5.60702644943265,-0.426978669341551,"ZGRF1","zinc finger GRF-type containing 1",TRUE
+"231204_at",0.901788521024914,0.599442278056447,-0.532849008818198,-5.80233080780313,-0.215763472709522,"ZGRF1","zinc finger GRF-type containing 1",TRUE
+"1565934_at",0.959573917194453,0.817321798179963,0.233754549783974,-5.91310475985281,0.212573106039612,"ZGRF1","zinc finger GRF-type containing 1",TRUE
+"223214_s_at",0.55937703282623,0.0538266592311014,-2.03648329342764,-4.09938599877092,-1.11752724402192,"ZHX1","zinc fingers and homeoboxes 1",TRUE
+"223213_s_at",0.610404195568275,0.082786792094107,-1.81688921848805,-4.44827235305226,-0.982736950294404,"ZHX1","zinc fingers and homeoboxes 1",TRUE
+"1554063_at",0.975265330414469,0.880424308245818,-0.152177316523243,-5.92841039468189,-0.0768972053226484,"ZHX1-C8orf76","ZHX1-C8orf76 readthrough",TRUE
+"203556_at",0.937655803006818,0.724238638706131,-0.357312705759415,-5.87768957398759,-0.412073611374609,"ZHX2","zinc fingers and homeoboxes 2",TRUE
+"1557706_at",0.998870448604467,0.995961339031085,-0.00511915041101439,-5.93967071692643,-0.00302102149528238,"ZHX2","zinc fingers and homeoboxes 2",TRUE
+"212545_s_at",0.712975827977365,0.187516558249451,-1.35997415084006,-5.07688628496071,-0.978518094325858,"ZHX3","zinc fingers and homeoboxes 3",TRUE
+"217367_s_at",0.843475287501313,0.438520781067647,-0.788917683352446,-5.64100292326796,-0.594682551177519,"ZHX3","zinc fingers and homeoboxes 3",TRUE
+"206373_at",0.748789806497411,0.241940936837371,1.20229617715794,-5.25913113083674,2.71428053674008,"ZIC1","Zic family member 1",TRUE
+"236896_at",0.908667507590078,0.620170837116582,0.502648729930687,-5.81736780500013,0.476691109545035,"ZIC1","Zic family member 1",TRUE
+"234716_at",0.95852392877631,0.812019877642125,0.240675200527792,-5.91150988224084,0.179510896454503,"ZIC1","Zic family member 1",TRUE
+"223642_at",0.387357699611418,0.0127714119878656,-2.70889904095046,-2.88504288404132,-2.7382452797782,"ZIC2","Zic family member 2",TRUE
+"207197_at",0.597879550155311,0.0752623879796392,1.86650100696974,-4.37187921061293,1.50962648090936,"ZIC3","Zic family member 3",TRUE
+"236711_at",0.838349550050823,0.423261106165577,0.815866607876605,-5.6205740973936,0.277540146355264,"ZIC4","Zic family member 4",TRUE
+"211463_at",0.924336085471855,0.67361996023093,0.426832827809055,-5.8513347434849,0.359677306362638,"ZIC4","Zic family member 4",TRUE
+"1552938_at",0.708772314163123,0.180800136545644,1.38182555693496,-5.05014115981006,1.03714339779144,"ZIC5","Zic family member 5",TRUE
+"235773_at",0.579625094592471,0.0624415511138482,1.96202303246266,-4.22074431439941,1.26326999594119,"ZIK1","zinc finger protein interacting with K protein 1",TRUE
+"232774_x_at",0.698480416742743,0.169780570401428,1.41911658142701,-5.00368457001864,1.56280614845032,"ZIK1","zinc finger protein interacting with K protein 1",TRUE
+"220653_at",0.998870448604467,0.996198431795842,0.00481862415801578,-5.93967217156901,0.00198878373276834,"ZIM2///PEG3","zinc finger imprinted 2///paternally expressed 3",TRUE
+"1553022_at",0.599747222491044,0.0762473083655691,1.85976790188212,-4.38233285374324,1.57910241294872,"ZIM3","zinc finger imprinted 3",TRUE
+"225221_at",0.670970797333726,0.136930812192953,-1.54326026963203,-4.84181367230405,-0.623817758493788,"ZKSCAN1","zinc finger with KRAB and SCAN domains 1",TRUE
+"1557953_at",0.784789297644843,0.309155712029291,-1.040882108516,-5.42532524381785,-0.514240600274132,"ZKSCAN1","zinc finger with KRAB and SCAN domains 1",TRUE
+"214670_at",0.826134344333512,0.393945580712635,-0.869406907869945,-5.578084859502,-0.360298508932042,"ZKSCAN1","zinc finger with KRAB and SCAN domains 1",TRUE
+"214900_at",0.991294074866043,0.959220929581397,-0.0517128042814849,-5.93838105358137,-0.0187962307964398,"ZKSCAN1","zinc finger with KRAB and SCAN domains 1",TRUE
+"232019_at",0.930827859648584,0.693650176710132,0.399086194359481,-5.86240536910769,0.223428016126963,"ZKSCAN2","zinc finger with KRAB and SCAN domains 2",TRUE
+"1562303_at",0.799039781143356,0.333704149293596,0.988241841008435,-5.47488269267183,0.856971727855144,"ZKSCAN3","zinc finger with KRAB and SCAN domains 3",TRUE
+"211773_s_at",0.832605695407954,0.408940728765609,0.841715234710505,-5.60037549128538,0.292062352771739,"ZKSCAN3","zinc finger with KRAB and SCAN domains 3",TRUE
+"235840_at",0.89316156038085,0.567183367517389,-0.580880320924052,-5.77666063234166,-0.229008560642863,"ZKSCAN3","zinc finger with KRAB and SCAN domains 3",TRUE
+"1562305_x_at",0.934081042629428,0.708174753627661,0.379164997520235,-5.86990187668303,0.148769575170654,"ZKSCAN3","zinc finger with KRAB and SCAN domains 3",TRUE
+"213625_at",0.973433731874338,0.871660246803802,-0.163431515270983,-5.926682459969,-0.0556964558311073,"ZKSCAN4","zinc finger with KRAB and SCAN domains 4",TRUE
+"203731_s_at",0.729083413548563,0.210782789014949,1.28874000036727,-5.16158392032346,0.511677640720209,"ZKSCAN5","zinc finger with KRAB and SCAN domains 5",TRUE
+"203730_s_at",0.869487815945782,0.506823533501455,0.674736286444677,-5.72033868160118,0.196041169690565,"ZKSCAN5","zinc finger with KRAB and SCAN domains 5",TRUE
+"206314_at",0.644953768720197,0.115413400515014,1.6386336522082,-4.71019238393425,2.27060115176562,"ZKSCAN7","zinc finger with KRAB and SCAN domains 7",TRUE
+"234292_s_at",0.800393752157075,0.336189705193456,-0.983063777489423,-5.47963142588139,-0.645318398644141,"ZKSCAN7","zinc finger with KRAB and SCAN domains 7",TRUE
+"1557402_at",0.686747966354964,0.155286883306714,1.47124138805865,-4.93705359938414,0.986132128718221,"ZKSCAN8","zinc finger with KRAB and SCAN domains 8",TRUE
+"206579_at",0.812302873476553,0.356898560947107,0.94090695884463,-5.51744450320038,0.438103425152081,"ZKSCAN8","zinc finger with KRAB and SCAN domains 8",TRUE
+"226102_at",0.812302873476553,0.357710231301777,0.939288826432824,-5.51886565549196,0.461451746543144,"ZKSCAN8","zinc finger with KRAB and SCAN domains 8",TRUE
+"226344_at",0.48580305784244,0.0282719073879137,-2.34688957078084,-3.56304949754633,-2.33656858990113,"ZMAT1","zinc finger matrin-type 1",TRUE
+"241328_at",0.895213601869362,0.572955152042961,0.572187819642497,-5.78146543324688,0.325115000963578,"ZMAT1","zinc finger matrin-type 1",TRUE
+"224782_at",0.784708646973769,0.308583677839844,-1.04214313783311,-5.42410960426829,-0.314186181679402,"ZMAT2","zinc finger matrin-type 2",TRUE
+"225725_at",0.8288884913487,0.399691844446847,-0.858716555705491,-5.58676977152871,-0.5170568566071,"ZMAT3","zinc finger matrin-type 3",TRUE
+"227221_at",0.855439520086837,0.468593437517802,-0.73743941604812,-5.67822566841363,-0.307664139217978,"ZMAT3","zinc finger matrin-type 3",TRUE
+"228315_at",0.884024105338928,0.542630848436418,-0.618378963597972,-5.75513097120354,-0.213747094231532,"ZMAT3","zinc finger matrin-type 3",TRUE
+"219628_at",0.936992192746977,0.718193403460394,-0.365514892481898,-5.87481996567879,-0.168182792150839,"ZMAT3","zinc finger matrin-type 3",TRUE
+"1555609_a_at",0.940668681806864,0.734343241217124,0.34365801018329,-5.88232405927701,0.115957257186283,"ZMAT3","zinc finger matrin-type 3",TRUE
+"219877_at",0.947001578829888,0.759371232686255,-0.310115518085412,-5.8929500735235,-0.27948281572453,"ZMAT4","zinc finger matrin-type 4",TRUE
+"218752_at",0.76912869907427,0.274851770272136,-1.11965528143079,-5.34686433121625,-0.60688018001638,"ZMAT5","zinc finger matrin-type 5",TRUE
+"212124_at",0.461822652528876,0.0232283913023212,-2.43824664749485,-3.39677132326522,-0.97755618450546,"ZMIZ1","zinc finger MIZ-type containing 1",TRUE
+"233060_at",0.989768753740502,0.950695087109759,-0.0625380701092578,-5.93777875139437,-0.0373506040680454,"ZMIZ1","zinc finger MIZ-type containing 1",TRUE
+"232508_at",0.999630252558032,0.99917317425325,-0.00104802727509193,-5.93968294577789,-0.000551032313063082,"ZMIZ1","zinc finger MIZ-type containing 1",TRUE
+"1563745_a_at",0.93565329131222,0.713424796352502,0.372002991531874,-5.8725045084337,0.164616020762307,"ZMIZ1-AS1","ZMIZ1 antisense RNA 1",TRUE
+"236309_x_at",0.711977799428804,0.185761876340741,1.36562237516834,-5.07000713727543,0.782789923798163,"ZMIZ2","zinc finger MIZ-type containing 2",TRUE
+"221525_at",0.749865605544857,0.242713701350294,1.20026249058138,-5.26135558368654,1.00007224712699,"ZMIZ2","zinc finger MIZ-type containing 2",TRUE
+"221924_at",0.789795896476304,0.317910785731656,1.02178381145777,-5.4435738380188,0.461691838898391,"ZMIZ2","zinc finger MIZ-type containing 2",TRUE
+"54970_at",0.937856707467078,0.725085947002206,0.356165082543331,-5.87808595081855,0.165881279679033,"ZMIZ2","zinc finger MIZ-type containing 2",TRUE
+"202939_at",0.671298718565642,0.137343289248703,-1.54155729745965,-4.84410755969854,-0.570077335692675,"ZMPSTE24","zinc metallopeptidase STE24",TRUE
+"220206_at",0.93613089056626,0.714626997904976,0.370365770231759,-5.87309258878169,0.113037825158523,"ZMYM1","zinc finger MYM-type containing 1",TRUE
+"202778_s_at",0.632216562924782,0.103047534238138,-1.70042181723877,-4.62169268689346,-0.782129582359685,"ZMYM2","zinc finger MYM-type containing 2",TRUE
+"210281_s_at",0.640067422642767,0.110782161163824,-1.6610880753768,-4.6783188988639,-0.852427818701653,"ZMYM2","zinc finger MYM-type containing 2",TRUE
+"226512_at",0.646767005028134,0.117911228101645,-1.6268358118473,-4.72680571274859,-0.711786369384237,"ZMYM2","zinc finger MYM-type containing 2",TRUE
+"242597_at",0.76524135343539,0.26536444174549,-1.1426917047041,-5.32296017168608,-0.829169857779255,"ZMYM2","zinc finger MYM-type containing 2",TRUE
+"241800_x_at",0.94632739401154,0.757101008345316,-0.313142562382143,-5.89203544812141,-0.16154307622941,"ZMYM2","zinc finger MYM-type containing 2",TRUE
+"210282_at",0.955515814503015,0.79608806629977,0.26154515279101,-5.90642031817067,0.214438029326725,"ZMYM2","zinc finger MYM-type containing 2",TRUE
+"240642_at",0.959623505183049,0.817723550218862,-0.233230618512047,-5.91322361630442,-0.242291073740196,"ZMYM2","zinc finger MYM-type containing 2",TRUE
+"1554172_a_at",0.708894565317004,0.181408128482765,-1.37982128487004,-5.05260905734389,-0.437722702737099,"ZMYM3","zinc finger MYM-type containing 3",TRUE
+"207559_s_at",0.727294834785485,0.207676602071242,-1.29788417558884,-5.15092694540983,-0.362624484980792,"ZMYM3","zinc finger MYM-type containing 3",TRUE
+"1554171_at",0.993892931327222,0.971415787581116,0.0362396572361777,-5.93904383477123,0.0128842115901229,"ZMYM3","zinc finger MYM-type containing 3",TRUE
+"202050_s_at",0.76029267756668,0.258841256978661,-1.15888468505141,-5.30590073758306,-0.325676281979044,"ZMYM4","zinc finger MYM-type containing 4",TRUE
+"202049_s_at",0.843095426822889,0.437213575376289,-0.791203300724067,-5.6392953355826,-0.208953166497837,"ZMYM4","zinc finger MYM-type containing 4",TRUE
+"202051_s_at",0.951810226174863,0.779129490451067,-0.283891551625153,-5.90050497219003,-0.0736392535256787,"ZMYM4","zinc finger MYM-type containing 4",TRUE
+"235620_x_at",0.348854934125219,0.00918760202445876,-2.85398759448882,-2.60045496787803,-1.39438893465901,"ZMYM5","zinc finger MYM-type containing 5",TRUE
+"206652_at",0.672434875127089,0.138340110140807,-1.5374591067886,-4.84961956010488,-0.609397207616261,"ZMYM5","zinc finger MYM-type containing 5",TRUE
+"215948_x_at",0.683171064712775,0.152265616727753,-1.48259950785228,-4.92227600806736,-0.65285148818382,"ZMYM5","zinc finger MYM-type containing 5",TRUE
+"206744_s_at",0.767011398042819,0.26859287551081,-1.13478584260018,-5.33121225920002,-0.605639643546562,"ZMYM5","zinc finger MYM-type containing 5",TRUE
+"227594_at",0.637485146909712,0.108949893037103,-1.67019073863702,-4.66530371974255,-0.452104361251346,"ZMYM6","zinc finger MYM-type containing 6",TRUE
+"219924_s_at",0.769847953580141,0.27811264703888,1.11187179631786,-5.3548436473932,0.665304238191883,"ZMYM6","zinc finger MYM-type containing 6",TRUE
+"1561892_at",0.82064687791745,0.381424463859138,-0.893056603191144,-5.55851739710549,-0.652297783998227,"ZMYM6","zinc finger MYM-type containing 6",TRUE
+"1552970_s_at",0.859502367311367,0.477304477568602,-0.72289843412356,-5.68830880048827,-0.321933271347983,"ZMYM6","zinc finger MYM-type containing 6",TRUE
+"1552969_a_at",0.898609426925686,0.588068986639492,0.549632991672731,-5.79360500691466,0.233382078552189,"ZMYM6","zinc finger MYM-type containing 6",TRUE
+"227595_at",0.971242929121865,0.863250965269643,0.174250463574736,-5.9249054854359,0.0573197993828076,"ZMYM6","zinc finger MYM-type containing 6",TRUE
+"219925_at",0.990810941805126,0.955744601807525,0.0561258594456988,-5.93814929375629,0.0213583622184412,"ZMYM6","zinc finger MYM-type containing 6",TRUE
+"205714_s_at",0.778007390824139,0.297314787582248,1.06733011268948,-5.39955246921935,0.78231529814982,"ZMYND10","zinc finger MYND-type containing 10",TRUE
+"216663_s_at",0.831875452294783,0.407023307741532,0.84521950109294,-5.59759188007353,0.655887017168324,"ZMYND10","zinc finger MYND-type containing 10",TRUE
+"202137_s_at",0.702621412021935,0.174060215617305,-1.40441088260073,-5.02212657349866,-0.47359953827827,"ZMYND11","zinc finger MYND-type containing 11",TRUE
+"1554159_a_at",0.805859691692007,0.346201699770339,-0.962468190549121,-5.4982941384039,-0.668342463238282,"ZMYND11","zinc finger MYND-type containing 11",TRUE
+"202136_at",0.812302873476553,0.359314656192329,-0.936097522363223,-5.52166188946313,-0.334271297009119,"ZMYND11","zinc finger MYND-type containing 11",TRUE
+"1554158_at",0.94895689004559,0.769284251807183,-0.296931980082024,-5.89683081142978,-0.111803707643103,"ZMYND11","zinc finger MYND-type containing 11",TRUE
+"223636_at",0.884122836669679,0.542876486011421,0.617999435698439,-5.75535538263171,0.384539283505724,"ZMYND12","zinc finger MYND-type containing 12",TRUE
+"223683_at",0.62986301194198,0.100934245589948,1.7116037666133,-4.60541263413177,1.17320453193208,"ZMYND15","zinc finger MYND-type containing 15",TRUE
+"227477_at",0.335132216913431,0.008262610487413,-2.90023912292419,-2.50842123178588,-1.13322637652654,"ZMYND19","zinc finger MYND-type containing 19",TRUE
+"209049_s_at",0.565956563686213,0.056746609411453,-2.01012976653227,-4.14268361050339,-0.801229593327754,"ZMYND8","zinc finger MYND-type containing 8",TRUE
+"209048_s_at",0.774479064996015,0.290902065973449,-1.08196849890199,-5.38503895222653,-0.426427603236244,"ZMYND8","zinc finger MYND-type containing 8",TRUE
+"230533_at",0.868397087637799,0.503928746535716,-0.679387319421852,-5.71733752114747,-0.230786529566261,"ZMYND8","zinc finger MYND-type containing 8",TRUE
+"214795_at",0.914242258486146,0.639323847922857,-0.475159531655505,-5.83031032710013,-0.200970437403349,"ZMYND8","zinc finger MYND-type containing 8",TRUE
+"207130_at",0.918515815942389,0.653962566043047,-0.454398194024723,-5.83961312309034,-0.264835290977748,"ZMYND8","zinc finger MYND-type containing 8",TRUE
+"216350_s_at",0.812498481719966,0.361059012122533,0.932638726265728,-5.52468262822633,0.376559218049768,"ZNF10","zinc finger protein 10",TRUE
+"229848_at",0.943512938262733,0.747452681449763,0.326041092523537,-5.88803952739087,0.230036895448475,"ZNF10","zinc finger protein 10",TRUE
+"235366_at",0.952613441433926,0.782984418821552,0.278799329262364,-5.90189527118522,0.103706270209117,"ZNF10","zinc finger protein 10",TRUE
+"238791_at",0.599675851559629,0.0760018372551579,-1.86143886443597,-4.3797410570684,-0.694848002597839,"ZNF100","zinc finger protein 100",TRUE
+"1552633_at",0.654810179364368,0.123704331827244,-1.60025905467397,-4.76389029271495,-0.80712825437049,"ZNF101","zinc finger protein 101",TRUE
+"239231_at",0.680586794685785,0.148260579298906,-1.49794211796896,-4.90216909429378,-0.542461692528336,"ZNF101","zinc finger protein 101",TRUE
+"1552634_a_at",0.69385705848116,0.163282300466766,-1.44202459910177,-4.9746426775914,-0.531881806336641,"ZNF101","zinc finger protein 101",TRUE
+"217781_s_at",0.86486291642905,0.492881773215987,-0.697276857512602,-5.70561040401618,-0.266642786938643,"ZNF106","zinc finger protein 106",TRUE
+"222407_s_at",0.909052380289506,0.622804306640206,0.498846187297085,-5.81920048627453,0.214463496274925,"ZNF106","zinc finger protein 106",TRUE
+"205739_x_at",0.453601396285638,0.0219105859641586,-2.46514527621026,-3.34715377426146,-1.14250264984748,"ZNF107","zinc finger protein 107",TRUE
+"243312_at",0.774230543658252,0.288503793032856,1.08750258728632,-5.37950610029754,0.458505025288439,"ZNF107","zinc finger protein 107",TRUE
+"1560854_s_at",0.844169896707408,0.440783007969469,0.784972100288791,-5.64393972622694,0.344809037313386,"ZNF107","zinc finger protein 107",TRUE
+"222237_s_at",0.993773193220256,0.970532807171305,-0.0373596544156076,-5.93900368828092,-0.031852186921209,"ZNF112","zinc finger protein 112",TRUE
+"1552947_x_at",0.668407131834285,0.134558615142254,1.55313720400252,-4.82847006479682,1.15393897805918,"ZNF114","zinc finger protein 114",TRUE
+"1552946_at",0.683838837468118,0.152835889994611,1.48044169342754,-4.92509051053077,1.02285124388336,"ZNF114","zinc finger protein 114",TRUE
+"235408_x_at",0.747801520625535,0.239706802935219,-1.20820337100884,-5.25265128232921,-0.506669536955973,"ZNF117","zinc finger protein 117",TRUE
+"235564_at",0.857148066512338,0.471974182198184,-0.731777340586031,-5.68217458264338,-0.419303732956289,"ZNF117","zinc finger protein 117",TRUE
+"207605_x_at",0.901015420810252,0.597236533203172,-0.536091875850851,-5.80066538540118,-0.184061608168017,"ZNF117","zinc finger protein 117",TRUE
+"207117_at",0.975794187312778,0.884224580456074,-0.147303605794307,-5.92912053621008,-0.0744863565193681,"ZNF117","zinc finger protein 117",TRUE
+"226015_at",0.946727564264032,0.758602907659555,-0.311139645598959,-5.89264161722464,-0.139051176431966,"ZNF12","zinc finger protein 12",TRUE
+"1554021_a_at",0.94960065125426,0.772020551031677,-0.29330245837661,-5.89786986845757,-0.110135860404899,"ZNF12","zinc finger protein 12",TRUE
+"219571_s_at",0.957481612329989,0.808155953270686,-0.245726380971374,-5.9103166185038,-0.0920947133170174,"ZNF12","zinc finger protein 12",TRUE
+"1559881_s_at",0.967098323798013,0.846398662046094,-0.195997398004036,-5.92099026214183,-0.0832427710295107,"ZNF12","zinc finger protein 12",TRUE
+"1553979_at",0.78885145722244,0.315165454623996,1.02773223845813,-5.43792275427602,0.369753515887469,"ZNF121","zinc finger protein 121",TRUE
+"206928_at",0.86219003266709,0.485144514952044,-0.709943587603591,-5.69713119431186,-0.437076383601191,"ZNF124","zinc finger protein 124",TRUE
+"234394_at",0.94791820805579,0.762599548231221,-0.305816064679931,-5.89423402779249,-0.180344159018886,"ZNF124","zinc finger protein 124",TRUE
+"207402_at",0.814709480171015,0.365579924764804,0.923726219952761,-5.53241897099996,0.722981328957875,"ZNF132","zinc finger protein 132",TRUE
+"37254_at",0.873709858086966,0.519415916365043,0.654675097466532,-5.73305719015005,0.207460370584458,"ZNF133","zinc finger protein 133",TRUE
+"216960_s_at",0.909732972837956,0.624538553084875,0.496346127234484,-5.82039801727686,0.182258351233832,"ZNF133","zinc finger protein 133",TRUE
+"206182_at",0.993225426079816,0.968132479088778,0.0404045498542403,-5.93888836800361,0.0188492212643574,"ZNF134","zinc finger protein 134",TRUE
+"206142_at",0.840872144163754,0.430269054292067,0.803416857382311,-5.63009183131808,1.28172712432369,"ZNF135","zinc finger protein 135",TRUE
+"1567410_at",0.901788521024914,0.599722566807188,0.532437345194996,-5.80254152055078,0.166183742937903,"ZNF135","zinc finger protein 135",TRUE
+"206240_s_at",0.986455005400648,0.937216718734797,0.079667723662475,-5.93659259002647,0.0353622706311345,"ZNF136","zinc finger protein 136",TRUE
+"207394_at",0.740476003158683,0.229592663547698,1.23547824023522,-5.22237606981246,0.749955196373643,"ZNF137P","zinc finger protein 137, pseudogene",TRUE
+"244743_x_at",0.279325273101419,0.00452719677640194,-3.15867251407155,-1.98408731858107,-1.31205580509419,"ZNF138","zinc finger protein 138",TRUE
+"1559709_at",0.937623890519979,0.723614276466424,-0.358158676203395,-5.87739657837894,-0.200584548826617,"ZNF138","zinc finger protein 138",TRUE
+"219854_at",0.597317657494274,0.0732076016985666,-1.88079911484221,-4.34959191423129,-0.806633000766127,"ZNF14","zinc finger protein 14",TRUE
+"204523_at",0.833947935066508,0.411725745044336,-0.836643918151949,-5.60438476186417,-0.336492220132728,"ZNF140","zinc finger protein 140",TRUE
+"235580_at",0.661221664662217,0.128961625786912,-1.57702443701203,-4.79592186732679,-0.738295632052449,"ZNF141","zinc finger protein 141",TRUE
+"206931_at",0.812302873476553,0.360058006502099,-0.934622195580505,-5.52295162232851,-0.383246548469942,"ZNF141","zinc finger protein 141",TRUE
+"37586_at",0.847572140249536,0.446411246872719,-0.775209260631035,-5.65114680521021,-0.244214238173072,"ZNF142","zinc finger protein 142",TRUE
+"204474_at",0.958458152287023,0.811766285467858,-0.241006515533282,-5.91143236936809,-0.0689309759220009,"ZNF142","zinc finger protein 142",TRUE
+"206428_s_at",0.789406360796076,0.316139913923998,1.02561669002164,-5.43993594709394,0.439578320537576,"ZNF143","zinc finger protein 143",TRUE
+"221873_at",0.944247754024473,0.750320766737032,0.322201047263241,-5.8892458531623,0.0846263745041593,"ZNF143","zinc finger protein 143",TRUE
+"200050_at",0.55937703282623,0.0538534482827024,-2.03623578300377,-4.09979438249522,-0.635865901843882,"ZNF146","zinc finger protein 146",TRUE
+"1554433_a_at",0.673190784310977,0.138782342528743,-1.5356487571405,-4.85205074705224,-0.499597729841827,"ZNF146","zinc finger protein 146",TRUE
+"238711_s_at",0.762729892034689,0.26227114439365,-1.15033334167187,-5.31493594278053,-0.420063314914952,"ZNF148","zinc finger protein 148",TRUE
+"239024_at",0.7717895132349,0.281773012222719,-1.10321344632369,-5.36366181823044,-0.481774544145852,"ZNF148","zinc finger protein 148",TRUE
+"203319_s_at",0.962741248200658,0.830444204443023,-0.21667504805311,-5.91684263901711,-0.069064834033183,"ZNF148","zinc finger protein 148",TRUE
+"228545_at",0.965707350334601,0.839789221490208,-0.204552381586485,-5.91932446674336,-0.0813205468529645,"ZNF148","zinc finger protein 148",TRUE
+"230821_at",0.978951900396372,0.89769025026201,-0.13006290291227,-5.93144750338598,-0.0798906898272733,"ZNF148","zinc finger protein 148",TRUE
+"235166_at",0.982723176827697,0.916028142524207,-0.106647792970026,-5.93414526355086,-0.0440779897512495,"ZNF148","zinc finger protein 148",TRUE
+"203318_s_at",0.990810941805126,0.9554225156246,-0.0565347910588077,-5.93812685794501,-0.0211515900990502,"ZNF148","zinc finger protein 148",TRUE
+"216677_at",0.571677937624457,0.059331134814623,1.98779094284749,-4.17909025283774,0.540724541700287,"ZNF154","zinc finger protein 154",TRUE
+"217242_at",0.808266620412549,0.351202379536185,0.952333192659739,-5.50734538486287,0.571621061689999,"ZNF154","zinc finger protein 154",TRUE
+"221201_s_at",0.65086850539757,0.120745482400504,-1.61370002890932,-4.74519415178,-0.451490822383806,"ZNF155","zinc finger protein 155",TRUE
+"208019_at",0.956643574784498,0.803242752203475,0.252158715654211,-5.90876141487973,0.259077250990316,"ZNF157","zinc finger protein 157",TRUE
+"219548_at",0.952041062962677,0.780664965263936,0.281862333302851,-5.90106199038054,0.104352522443909,"ZNF16","zinc finger protein 16",TRUE
+"1567031_at",0.820293495506061,0.379368109934896,0.89698890762506,-5.55521669391756,0.534970539154804,"ZNF160","zinc finger protein 160",TRUE
+"239954_at",0.838991915745708,0.4244554038293,0.813735876449846,-5.62221276355671,0.511392270638009,"ZNF160","zinc finger protein 160",TRUE
+"214715_x_at",0.900535738777606,0.59548878921049,0.538665529061922,-5.79933665277389,0.169083725528505,"ZNF160","zinc finger protein 160",TRUE
+"224014_at",0.959203345279235,0.815092894894058,0.236662518138025,-5.91244025025202,0.131151273373406,"ZNF160","zinc finger protein 160",TRUE
+"1567032_s_at",0.971216837324271,0.862177995736152,-0.175632395866895,-5.92467033030356,-0.060674231624958,"ZNF160","zinc finger protein 160",TRUE
+"206683_at",0.304824368772306,0.00598157879294756,3.03975040213588,-2.22735923745781,1.40123560798986,"ZNF165","zinc finger protein 165",TRUE
+"1560921_at",0.662855903464759,0.130692007971415,1.56954917073642,-4.80614944224024,0.512455537176004,"ZNF169","zinc finger protein 169",TRUE
+"1570354_s_at",0.724970327905974,0.202960527421182,1.31197254891475,-5.1343828365904,0.612045045972757,"ZNF169","zinc finger protein 169",TRUE
+"1560922_s_at",0.806649582904638,0.34759647156305,0.95963142655245,-5.50083639569198,0.322318613509671,"ZNF169","zinc finger protein 169",TRUE
+"1558183_at",0.255716413540338,0.00370888186442594,-3.24310302775872,-1.80955940327964,-1.77557834006615,"ZNF17","zinc finger protein 17",TRUE
+"1558184_s_at",0.722442821599878,0.198970752357407,-1.32409157221566,-5.12003061972993,-0.810660147288887,"ZNF17","zinc finger protein 17",TRUE
+"210291_s_at",0.232037111848437,0.0029792627134142,-3.33529674248456,-1.61745814099443,-1.5357924813505,"ZNF174","zinc finger protein 174",TRUE
+"205252_at",0.317600554649094,0.00691462961489811,-2.97738141538083,-2.35362409193462,-0.811765787655162,"ZNF174","zinc finger protein 174",TRUE
+"210290_at",0.446963972064621,0.0211453427942259,-2.48146339819216,-3.31691175432202,-0.985740522905137,"ZNF174","zinc finger protein 174",TRUE
+"205497_at",0.757270745916058,0.253090127387433,-1.17341370680785,-5.29041513185869,-1.11253734509136,"ZNF175","zinc finger protein 175",TRUE
+"243128_at",0.89967769475675,0.591115612849219,0.545121493706023,-5.79597632776454,0.360521468494564,"ZNF175","zinc finger protein 175",TRUE
+"226787_at",0.522403182336918,0.0382207435591441,-2.20384404099564,-3.81600108934183,-1.14539734108246,"ZNF18","zinc finger protein 18",TRUE
+"219495_s_at",0.498703893437511,0.0313368717932738,-2.29846914785933,-3.64971773278137,-0.831566342890986,"ZNF180","zinc finger protein 180",TRUE
+"230065_at",0.588709322600978,0.0675185711186473,-1.92230219220373,-4.28422535231168,-1.45375405561372,"ZNF180","zinc finger protein 180",TRUE
+"235810_at",0.819723837900625,0.377155425079618,-0.90123584312943,-5.551636831252,-0.286633893522898,"ZNF182","zinc finger protein 182",TRUE
+"244024_at",0.854163696308241,0.463845816466403,-0.745431714264539,-5.67260245033037,-0.273706843200037,"ZNF182","zinc finger protein 182",TRUE
+"213452_at",0.944801723928361,0.751838296352581,0.32017124623339,-5.88987778581756,0.109164597139854,"ZNF184","zinc finger protein 184",TRUE
+"203585_at",0.722314275419786,0.19877349040633,1.32469566135772,-5.11931230222111,0.765194175803485,"ZNF185","zinc finger protein 185 (LIM domain)",TRUE
+"207513_s_at",0.90998880119877,0.625268014402875,-0.495295506474784,-5.82089951226987,-0.166819421621639,"ZNF189","zinc finger protein 189",TRUE
+"240836_at",0.581406183553129,0.0639201201524986,1.95016982796708,-4.23978098194432,0.759390998034279,"ZNF19","zinc finger protein 19",TRUE
+"228958_at",0.789795896476304,0.318258241690791,1.02103353370384,-5.4442845071026,0.290774325104742,"ZNF19","zinc finger protein 19",TRUE
+"234953_x_at",0.884122836669679,0.542839040158468,0.618057286352333,-5.75532118463838,0.19742780981497,"ZNF19","zinc finger protein 19",TRUE
+"204234_s_at",0.604522328036066,0.0786734718255498,-1.84349981723619,-4.40747947633052,-0.632298659617678,"ZNF195","zinc finger protein 195",TRUE
+"205855_at",0.831013183269159,0.404934912583137,0.849048234424691,-5.59453819396768,0.299868497395195,"ZNF197","zinc finger protein 197",TRUE
+"233070_at",0.936992192746977,0.717828257208487,0.36601113699442,-5.87464428732317,0.326792119008571,"ZNF197","zinc finger protein 197",TRUE
+"223792_at",0.849935057946582,0.45200334578629,-0.765583007682979,-5.6581697012234,-0.181162878878414,"ZNF2","zinc finger protein 2",TRUE
+"214706_at",0.274882222151803,0.00440116086101313,-3.17066178839469,-1.95939113644914,-1.07019193609933,"ZNF200","zinc finger protein 200",TRUE
+"207338_s_at",0.632216562924782,0.10341751848399,-1.6984842237515,-4.62450552668103,-0.556085686308588,"ZNF200","zinc finger protein 200",TRUE
+"204329_s_at",0.84772210282622,0.446895511051058,-0.774372762570995,-5.65176036401895,-0.385483649534033,"ZNF202","zinc finger protein 202",TRUE
+"204327_s_at",0.994347107169621,0.974232833726007,0.0326667470637912,-5.93916374107836,0.00991949955775162,"ZNF202","zinc finger protein 202",TRUE
+"214823_at",0.64513208805899,0.116025560490615,1.63572259198694,-4.71430021749962,1.4370230783815,"ZNF204P","zinc finger protein 204, pseudogene",TRUE
+"206416_at",0.804120194657066,0.342797137577812,-0.969425427275137,-5.49203016158327,-0.472289435252661,"ZNF205","zinc finger protein 205",TRUE
+"208136_s_at",0.344817137069397,0.00870990452845606,-2.87728834717538,-2.55416507301722,-1.76252083956654,"ZNF205-AS1","ZNF205 antisense RNA 1",TRUE
+"1556035_s_at",0.769847953580141,0.277427302078986,1.1135021277124,-5.35317638130419,0.797513747930095,"ZNF207","zinc finger protein 207",TRUE
+"228157_at",0.83571453859698,0.415113588280143,0.83050412907019,-5.60920843569754,0.60659778365017,"ZNF207","zinc finger protein 207",TRUE
+"231848_x_at",0.852153111602676,0.457837949973912,0.755615704772606,-5.665354006927,0.40219841525751,"ZNF207","zinc finger protein 207",TRUE
+"229765_at",0.870808709484996,0.51041609908819,0.668984836070497,-5.72402261725594,0.504807290090017,"ZNF207","zinc finger protein 207",TRUE
+"239937_at",0.899808883319249,0.593137603625243,0.54213360444615,-5.79753635936226,0.324887369691305,"ZNF207","zinc finger protein 207",TRUE
+"200828_s_at",0.940900986249919,0.735249850545637,0.342436166790282,-5.8827300604431,0.0760874305551749,"ZNF207","zinc finger protein 207",TRUE
+"200829_x_at",0.96261149778695,0.829920014366756,0.217356012190344,-5.9166990089211,0.0481294496347981,"ZNF207","zinc finger protein 207",TRUE
+"238772_at",0.982884736081404,0.91677001784472,-0.105701888660828,-5.93424304312701,-0.0795757862984336,"ZNF207","zinc finger protein 207",TRUE
+"244153_at",0.986455005400648,0.93685872530837,0.0801230072829617,-5.9365571670326,0.0253899515003244,"ZNF207","zinc finger protein 207",TRUE
+"1568646_x_at",0.708473702007515,0.180477634833259,1.38289086951116,-5.04882821091441,1.17083893379706,"ZNF208","zinc finger protein 208",TRUE
+"1568644_at",0.9941582295447,0.973411370104178,-0.0337085769831909,-5.9391300615753,-0.0303654167734049,"ZNF208","zinc finger protein 208",TRUE
+"205437_at",0.714323967815743,0.189284419674705,-1.35432551344769,-5.08374212852511,-0.577717126753462,"ZNF211","zinc finger protein 211",TRUE
+"203985_at",0.64484773720849,0.115322111278658,-1.639068879045,-4.70957774808801,-0.598549528046854,"ZNF212","zinc finger protein 212",TRUE
+"227207_x_at",0.896118635245982,0.578319981506036,-0.564147955721853,-5.78584699374771,-0.201649684741179,"ZNF213","zinc finger protein 213",TRUE
+"222170_at",0.561084367279569,0.0546946723549233,-2.02851881614191,-4.11251066426845,-1.61605419633977,"ZNF213-AS1","ZNF213 antisense RNA 1 (head to head)",TRUE
+"220497_at",0.823074246722209,0.389480504762535,-0.87778356766106,-5.57120983942852,-1.11712951858813,"ZNF214","zinc finger protein 214",TRUE
+"243456_at",0.857750641191636,0.473342147320917,0.729493066880111,-5.68375952761739,0.418912324579601,"ZNF214","zinc finger protein 214",TRUE
+"243457_s_at",0.951810226174863,0.778831875378997,0.28428500767979,-5.90039651001812,0.246974152530151,"ZNF214","zinc finger protein 214",TRUE
+"220214_at",0.528328646587879,0.0409778519672661,2.17025139487659,-3.87401076663882,2.34468072716063,"ZNF215","zinc finger protein 215",TRUE
+"1555510_at",0.84155387670388,0.433353961965159,0.797976403344154,-5.63420784915896,0.953006438851229,"ZNF215","zinc finger protein 215",TRUE
+"203739_at",0.380817197915441,0.0119590874411678,-2.73804704033234,-2.82839632721961,-1.3668773741795,"ZNF217","zinc finger protein 217",TRUE
+"222864_s_at",0.402799969339577,0.0149111502138693,2.63977142589254,-3.01825890475409,1.89308594463243,"ZNF219","zinc finger protein 219",TRUE
+"219314_s_at",0.727822268767891,0.20808191946329,1.29668499541805,-5.15232816105132,0.827217072731248,"ZNF219","zinc finger protein 219",TRUE
+"218005_at",0.871451481476429,0.512475597674376,0.665697926924546,-5.72611439578109,0.567914734400233,"ZNF22","zinc finger protein 22",TRUE
+"218006_s_at",0.899998627338565,0.594287552377378,0.540436554835883,-5.79841870878803,0.507662246135522,"ZNF22","zinc finger protein 22",TRUE
+"220847_x_at",0.871744769522775,0.51382821450265,0.663543188256196,-5.7274803080652,0.409552437143454,"ZNF221","zinc finger protein 221",TRUE
+"233848_x_at",0.94514040407998,0.752620446508169,0.319125602424801,-5.89020178015237,0.215006611991896,"ZNF221","zinc finger protein 221",TRUE
+"206175_x_at",0.955730092376044,0.797397299009495,-0.259825762499232,-5.9068555153212,-0.142724854352857,"ZNF222","zinc finger protein 222",TRUE
+"207128_s_at",0.943464796017993,0.746949894935125,0.326714781221656,-5.88782643372834,0.168904246816834,"ZNF223","zinc finger protein 223",TRUE
+"220019_s_at",0.399312926596283,0.0141418980770919,-2.66347834232312,-2.97275577818474,-0.864458952766571,"ZNF224","zinc finger protein 224",TRUE
+"244462_at",0.627053909308516,0.0978401007082571,-1.72834080567302,-4.58089578971822,-0.730690244237923,"ZNF224","zinc finger protein 224",TRUE
+"232427_at",0.756313947022433,0.251596700669999,1.1772266311651,-5.28632320252758,1.1004408541599,"ZNF224","zinc finger protein 224",TRUE
+"229123_at",0.791211889207316,0.321639083399643,-1.01376286252538,-5.45114689046754,-0.398750092031332,"ZNF224","zinc finger protein 224",TRUE
+"216991_at",0.801086839730802,0.33710589411325,0.981161761488591,-5.48137003574891,0.844044882671534,"ZNF224","zinc finger protein 224",TRUE
+"216983_s_at",0.976746068767032,0.888999555433962,0.141185034065384,-5.92997940830294,0.088217468505368,"ZNF224","zinc finger protein 224",TRUE
+"207125_at",0.386792041573721,0.0127197456012721,-2.71069999776558,-2.88155089012123,-0.990246619715709,"ZNF225","zinc finger protein 225",TRUE
+"235702_at",0.774230543658252,0.288983290362906,-1.08639349120454,-5.3806169655458,-0.622708556945405,"ZNF225","zinc finger protein 225",TRUE
+"233461_x_at",0.340590124506342,0.00847815563700287,-2.889035158778,-2.53077046247114,-1.11080769688692,"ZNF226","zinc finger protein 226",TRUE
+"219603_s_at",0.490107603095446,0.0292537112473038,-2.3308748797344,-3.59182929408676,-0.956654802730576,"ZNF226","zinc finger protein 226",TRUE
+"224004_at",0.724317760087277,0.201603432519583,-1.31607374236088,-5.12953838031454,-0.75654682683286,"ZNF226","zinc finger protein 226",TRUE
+"231717_s_at",0.999041264195616,0.99697648755448,-0.00383240485973076,-5.93967632709616,-0.00308047301526404,"ZNF226","zinc finger protein 226",TRUE
+"217403_s_at",0.638101654979046,0.109298554817466,-1.66844868665742,-4.66779872621725,-0.660027040564751,"ZNF227","zinc finger protein 227",TRUE
+"227689_at",0.645740804644555,0.116929742168205,-1.63144635807427,-4.72032428497819,-0.649433492496758,"ZNF227","zinc finger protein 227",TRUE
+"235717_at",0.632216562924782,0.103239400051217,1.69941628689037,-4.62315273457985,2.09349385245869,"ZNF229","zinc finger protein 229",TRUE
+"1562789_at",0.689932696175004,0.15917232922828,1.45689504384717,-4.95558752193693,1.08434574573821,"ZNF229","zinc finger protein 229",TRUE
+"213934_s_at",0.640473934798837,0.111191195045461,-1.65907337199859,-4.68119224458647,-0.760637295134133,"ZNF23","zinc finger protein 23",TRUE
+"1557322_at",0.54295328972902,0.0456850258799425,-2.1173596082266,-3.96421799331402,-0.74490942566811,"ZNF230","zinc finger protein 230",TRUE
+"205791_x_at",0.822241803732333,0.387002599921722,-0.882459161752426,-5.56734581004574,-0.562605917677446,"ZNF230","zinc finger protein 230",TRUE
+"1570135_at",0.935094665155941,0.711592688134603,0.374500047918811,-5.87160265185166,0.188813610925908,"ZNF230","zinc finger protein 230",TRUE
+"219123_at",0.976120892129083,0.885230513311906,0.146014149740389,-5.92930456260366,0.0552952101297013,"ZNF232","zinc finger protein 232",TRUE
+"230919_at",0.547195868806649,0.0476421340748466,-2.09680359696718,-3.99889508002149,-1.06314742118001,"ZNF233","zinc finger protein 233",TRUE
+"232986_at",0.797462038839093,0.330813653459707,-0.994297057690251,-5.46930075986044,-0.477128710346371,"ZNF233","zinc finger protein 233",TRUE
+"217663_at",0.597346378847428,0.0734386443298102,-1.87917405415712,-4.352131026062,-0.852604153124903,"ZNF234","zinc finger protein 234",TRUE
+"242953_at",0.961212424803935,0.823643619458985,0.225517811029936,-5.91494260071479,0.0680176478104784,"ZNF234","zinc finger protein 234",TRUE
+"210595_at",0.723973974120865,0.200977265318653,-1.31797329922684,-5.12729023862018,-0.78496607620835,"ZNF235","zinc finger protein 235",TRUE
+"220350_at",0.740476003158683,0.229767224575747,-1.23499984865042,-5.22291211331208,-0.853303535259213,"ZNF235","zinc finger protein 235",TRUE
+"219171_s_at",0.500677386446044,0.0319023438758614,-2.29001382570398,-3.66474448519025,-1.07193939131095,"ZNF236","zinc finger protein 236",TRUE
+"47571_at",0.643515428391208,0.11392386176133,-1.64577157150456,-4.70009627248907,-0.402681315129467,"ZNF236","zinc finger protein 236",TRUE
+"206261_at",0.975475861996229,0.883094293170626,-0.148752770974042,-5.92891178976631,-0.063147831833307,"ZNF239","zinc finger protein 239",TRUE
+"203248_at",0.399719600134805,0.0142212607212268,-2.66097707584446,-2.97756583062536,-0.985538330644378,"ZNF24","zinc finger protein 24",TRUE
+"203247_s_at",0.54613142770476,0.0473501747672889,-2.09982139489269,-3.99381775247352,-1.05495684437531,"ZNF24","zinc finger protein 24",TRUE
+"212534_at",0.622434989367596,0.0929251006515991,-1.75588102406344,-4.54016889196138,-0.646635944212996,"ZNF24","zinc finger protein 24",TRUE
+"242210_at",0.797963285726587,0.332208362321363,-0.991370780669811,-5.47200218535499,-0.512975022456389,"ZNF24","zinc finger protein 24",TRUE
+"1554045_at",0.945498722604777,0.75374333980085,0.317625058742662,-5.89066489217263,0.268618344970178,"ZNF24","zinc finger protein 24",TRUE
+"213269_at",0.986367034463604,0.935835455798171,0.08142446197946,-5.93645479580597,0.029183849968331,"ZNF248","zinc finger protein 248",TRUE
+"1569557_at",0.993474831312851,0.969348346633627,-0.0388621346462913,-5.93894791287416,-0.0170195330500418,"ZNF248","zinc finger protein 248",TRUE
+"228185_at",0.731548533938014,0.215114703507112,-1.27615977329721,-5.17614058566586,-0.608624129156455,"ZNF25","zinc finger protein 25",TRUE
+"235164_at",0.995678148676256,0.97936340902453,0.0261606323023458,-5.93935015062318,0.0173972571003773,"ZNF25","zinc finger protein 25",TRUE
+"241738_at",0.647470619495973,0.118255905007532,-1.6252243197576,-4.7290677883198,-0.793715772865393,"ZNF250","zinc finger protein 250",TRUE
+"213858_at",0.990810941805126,0.956112334451074,-0.0556589855148018,-5.93817470947643,-0.0233715891912176,"ZNF250","zinc finger protein 250",TRUE
+"226754_at",0.948988685362499,0.769818190442586,-0.296223427165009,-5.89703465089351,-0.19140000749603,"ZNF251","zinc finger protein 251",TRUE
+"233399_x_at",0.734203380012717,0.21853009108645,1.26637809072297,-5.18737481874127,0.375094147989458,"ZNF252P","zinc finger protein 252, pseudogene",TRUE
+"1558722_at",0.912241810302154,0.63193604241815,0.485717707391703,-5.82542342883633,0.233460794608135,"ZNF252P","zinc finger protein 252, pseudogene",TRUE
+"239753_at",0.96351240321323,0.833759663685801,0.212370417952876,-5.91774019580377,0.0737711358087578,"ZNF252P","zinc finger protein 252, pseudogene",TRUE
+"228200_at",0.990714197980362,0.953006356261164,0.0596027494763584,-5.93795334306633,0.0234202819180265,"ZNF252P","zinc finger protein 252, pseudogene",TRUE
+"1558790_s_at",0.528056136690037,0.0405389166712196,2.17545959297758,-3.86505299806799,1.01704870012796,"ZNF252P-AS1","ZNF252P antisense RNA 1",TRUE
+"242919_at",0.580137756009815,0.0626982132748278,-1.95994780005091,-4.22408289070342,-1.23120842611154,"ZNF253","zinc finger protein 253",TRUE
+"206900_x_at",0.80110325033185,0.337700554933638,-0.979929140890187,-5.48249512155045,-0.336975778701698,"ZNF253","zinc finger protein 253",TRUE
+"236133_x_at",0.582256319535811,0.0642691703410813,-1.94740694738377,-4.24420693673373,-1.00819694105781,"ZNF254","zinc finger protein 254",TRUE
+"1559449_a_at",0.662855903464759,0.130595266199997,1.56996492318488,-4.80558161542382,0.71677612187617,"ZNF254","zinc finger protein 254",TRUE
+"206862_at",0.796378050779806,0.328836737334593,-0.998459534420679,-5.46544566262666,-0.603819901724781,"ZNF254","zinc finger protein 254",TRUE
+"242602_x_at",0.920867548532508,0.66354675463256,-0.440915037486002,-5.84543648551628,-0.165594064920889,"ZNF254","zinc finger protein 254",TRUE
+"223714_at",0.922168942129244,0.667495139126682,0.435384605184735,-5.84777529341793,0.326920141852214,"ZNF256","zinc finger protein 256",TRUE
+"210697_at",0.990029426019097,0.951114251597063,-0.0620056885857952,-5.93781103998078,-0.085501569113478,"ZNF257","zinc finger protein 257",TRUE
+"217186_at",0.821424121108148,0.383224829789477,-0.889625219648202,-5.5613866680415,-0.602561943186199,"ZNF259P1","zinc finger protein 259 pseudogene 1",TRUE
+"217185_s_at",0.904885221062616,0.610399994971101,-0.51682356869046,-5.81041646364349,-0.168592024684935,"ZNF259P1///ZPR1","zinc finger protein 259 pseudogene 1///ZPR1 zinc finger",TRUE
+"1555325_s_at",0.907189812622248,0.615914864809352,-0.508809996443769,-5.81436948281606,-0.194840732547361,"ZNF26","zinc finger protein 26",TRUE
+"219595_at",0.995111934465262,0.977548459078723,0.0284620345996008,-5.93928892474019,0.0079544363268198,"ZNF26","zinc finger protein 26",TRUE
+"1558700_s_at",0.26338132901877,0.00395638830809231,-3.21580296734095,-1.86614540633218,-1.3379779949437,"ZNF260","zinc finger protein 260",TRUE
+"228920_at",0.309559393680685,0.00652240368578234,-3.00255041156269,-2.30278544795984,-1.0272285651914,"ZNF260","zinc finger protein 260",TRUE
+"230063_at",0.905462783815257,0.611685685348621,0.514952304867514,-5.8113449292901,0.585814304692457,"ZNF264","zinc finger protein 264",TRUE
+"205917_at",0.91238586368984,0.63301346561932,0.484174460127988,-5.82614428038453,0.383625790841695,"ZNF264","zinc finger protein 264",TRUE
+"1558698_at",0.944052844220435,0.750027753950567,-0.322593131016486,-5.88912333111036,-0.326156102918802,"ZNF264","zinc finger protein 264",TRUE
+"214686_at",0.769847953580141,0.278122662655262,1.11184799237508,-5.35486797456362,0.644938854786561,"ZNF266","zinc finger protein 266",TRUE
+"219540_at",0.88734438113787,0.551801576745923,-0.604270763215396,-5.76338367781877,-0.193021550502293,"ZNF267","zinc finger protein 267",TRUE
+"238030_at",0.796466121438385,0.329189643216486,-0.997715208984734,-5.46613609681836,-0.418757384717068,"ZNF268","zinc finger protein 268",TRUE
+"209989_at",0.836262350782426,0.417542312098938,-0.826122012372892,-5.61263088217723,-0.387187212481008,"ZNF268","zinc finger protein 268",TRUE
+"238192_at",0.925504446660705,0.67723938796895,-0.42179441423432,-5.85339936991924,-0.33935075812965,"ZNF268","zinc finger protein 268",TRUE
+"236231_at",0.457032025390949,0.0225502308749974,-2.45190683454969,-3.37161010202433,-1.84780395071501,"ZNF271P","zinc finger protein 271, pseudogene",TRUE
+"238007_at",0.635368778245437,0.106154441762927,-1.684330994634,-4.64497871792664,-0.615774545109137,"ZNF271P","zinc finger protein 271, pseudogene",TRUE
+"211009_s_at",0.729083413548563,0.211110366051008,-1.28778174982508,-5.16269699505312,-0.403451638866267,"ZNF271P","zinc finger protein 271, pseudogene",TRUE
+"215239_x_at",0.438807740024285,0.0201599002178882,-2.50330629314452,-3.27626639158634,-0.9247968769427,"ZNF273","zinc finger protein 273",TRUE
+"232436_at",0.630603891142543,0.101954478167111,1.70618084784713,-4.61331797980857,0.654225340456772,"ZNF274","zinc finger protein 274",TRUE
+"204937_s_at",0.778397054392363,0.298191827774483,1.06534570271769,-5.40150633705141,0.350924434336184,"ZNF274","zinc finger protein 274",TRUE
+"225382_at",0.875604460253057,0.523104601549261,-0.648849720968896,-5.7366814181706,-0.318155398556364,"ZNF275","zinc finger protein 275",TRUE
+"225383_at",0.96736913635524,0.847286203964878,0.194849754071281,-5.92120833448433,0.0695304851054424,"ZNF275","zinc finger protein 275",TRUE
+"213778_x_at",0.783844746433788,0.306726275719906,-1.04624914674955,-5.42014221332544,-0.320217903477249,"ZNF276","zinc finger protein 276",TRUE
+"231922_at",0.808257777979515,0.350688167095062,-0.953370824287065,-5.50642273855272,-0.328826435874638,"ZNF276","zinc finger protein 276",TRUE
+"215887_at",0.517859245504688,0.036994635508822,-2.21949501374469,-3.78878799583977,-0.885397094271883,"ZNF277","zinc finger protein 277",TRUE
+"1555192_at",0.910967291330762,0.628651832163477,0.490429256512112,-5.82320879142194,0.270506753929033,"ZNF277","zinc finger protein 277",TRUE
+"218645_at",0.983567332578112,0.919991539007597,-0.101595525692861,-5.934657435314,-0.0359029190656965,"ZNF277","zinc finger protein 277",TRUE
+"1555193_a_at",0.985031563903634,0.926152650621866,0.0937470867804379,-5.93540382487651,0.0333376413120892,"ZNF277","zinc finger protein 277",TRUE
+"1567853_at",0.789795896476304,0.317996238912197,1.02159923521975,-5.44374871385736,0.580200123482285,"ZNF28","zinc finger protein 28",TRUE
+"216034_at",0.843950128127185,0.440170747048312,0.786038725216526,-5.64314717662694,0.292185209848895,"ZNF280A","zinc finger protein 280A",TRUE
+"229360_at",0.51531387545335,0.0358125801918123,2.23503692915075,-3.7616491121257,2.4614014866648,"ZNF280B","zinc finger protein 280B",TRUE
+"230789_at",0.597879550155311,0.0753541468700548,1.86587049055853,-4.37285926849833,2.15650899373061,"ZNF280B","zinc finger protein 280B",TRUE
+"215048_at",0.920749013376768,0.662905608826029,0.441814394578329,-5.84505341030041,0.176528407818708,"ZNF280B","zinc finger protein 280B",TRUE
+"235520_at",0.973071267819624,0.870109695167327,-0.165424835050723,-5.92636359792826,-0.0605031379569718,"ZNF280C","zinc finger protein 280C",TRUE
+"222619_at",0.908030744859333,0.618474019725606,-0.50510279458812,-5.81617782813209,-0.205730181529919,"ZNF281","zinc finger protein 281",TRUE
+"218401_s_at",0.954387719376857,0.790246048354021,0.269227270576327,-5.90444106121301,0.0901495422017167,"ZNF281","zinc finger protein 281",TRUE
+"228785_at",0.954577684533304,0.791785373429569,-0.267201506525045,-5.90496851277941,-0.102467820738918,"ZNF281","zinc finger protein 281",TRUE
+"212892_at",0.605530510193664,0.0791093632247525,-1.84062340643652,-4.41190934982013,-0.609687092466695,"ZNF282","zinc finger protein 282",TRUE
+"243188_at",0.619415519928971,0.0896354018048106,-1.77502037830071,-4.51158604258026,-0.674734665371216,"ZNF283","zinc finger protein 283",TRUE
+"239462_at",0.975475861996229,0.882978031915162,0.148901850431019,-5.92889019978546,0.0867956307246613,"ZNF284","zinc finger protein 284",TRUE
+"1557684_at",0.588653540532996,0.0674264582712665,1.92299906218477,-4.28311933461704,0.686922820121916,"ZNF286A","zinc finger protein 286A",TRUE
+"239898_x_at",0.783884379328576,0.306860397186435,1.04595206682394,-5.42042973475386,0.550040782504863,"ZNF286A","zinc finger protein 286A",TRUE
+"220250_at",0.957289701021675,0.806705204905191,-0.247624577739768,-5.90986182907521,-0.106050214310998,"ZNF286A","zinc finger protein 286A",TRUE
+"227077_at",0.728385463227073,0.209347639919987,1.29295182098821,-5.15668325283857,0.411857124884948,"ZNF286B///ZNF286A","zinc finger protein 286B///zinc finger protein 286A",TRUE
+"216453_at",0.789378278298554,0.316011188941907,1.02589588901267,-5.43967047097745,0.63192364320854,"ZNF287","zinc finger protein 287",TRUE
+"216710_x_at",0.937842878751575,0.724807235393882,-0.356542525164668,-5.87795572516783,-0.377441230254714,"ZNF287","zinc finger protein 287",TRUE
+"220055_at",0.949976632131345,0.772943035335986,0.292079751916303,-5.89821705027378,0.242895194549377,"ZNF287","zinc finger protein 287",TRUE
+"212368_at",0.740270784944871,0.228700271520564,1.23792820752149,-5.21962804860902,0.389450266053309,"ZNF292","zinc finger protein 292",TRUE
+"1562991_at",0.772430642757484,0.282921496873057,1.10051361051797,-5.36639896538138,1.41047151023256,"ZNF292","zinc finger protein 292",TRUE
+"212366_at",0.803135302652907,0.341128690141902,0.97285214094186,-5.48892976707385,0.250979835368479,"ZNF292","zinc finger protein 292",TRUE
+"240809_at",0.874305976196739,0.520223338881819,-0.653398029038037,-5.73385437219149,-0.546072209724064,"ZNF295-AS1","ZNF295 antisense RNA 1",TRUE
+"238607_at",0.607162764223238,0.0808773006280355,-1.82909629418247,-4.42961225134265,-1.35549778572553,"ZNF296","zinc finger protein 296",TRUE
+"1567856_x_at",0.428576491758086,0.0186559131300273,2.53864181314347,-3.21012285324263,1.77290835631711,"ZNF29P","zinc finger protein 29, pseudogene",TRUE
+"1567855_at",0.675675845619713,0.142302832415382,1.52140379499296,-4.87110140859286,1.36525666917289,"ZNF29P","zinc finger protein 29, pseudogene",TRUE
+"232497_at",0.580630437263151,0.0629683700183611,-1.95777154877203,-4.2275813975339,-1.29957846905827,"ZNF3","zinc finger protein 3",TRUE
+"219605_at",0.789488409459128,0.316277124643616,1.02531917363288,-5.44021876848493,0.58219605682596,"ZNF3","zinc finger protein 3",TRUE
+"212684_at",0.876278327062923,0.524871231998129,-0.646067749829086,-5.73840123437709,-0.226153500172048,"ZNF3","zinc finger protein 3",TRUE
+"219604_s_at",0.97689149311934,0.89006576693488,-0.139819570663428,-5.93016611749152,-0.0849635022893507,"ZNF3","zinc finger protein 3",TRUE
+"232014_at",0.378791239547349,0.0116321991989026,-2.75030850908434,-2.80448566256003,-1.0365639306208,"ZNF30","zinc finger protein 30",TRUE
+"228144_at",0.83633038614858,0.417669677059777,0.825892653290522,-5.61280954563974,1.02739246589192,"ZNF300","zinc finger protein 300",TRUE
+"244289_at",0.981372324306002,0.911750328341409,-0.112104055336577,-5.9335642560736,-0.0811064054586064,"ZNF300P1","zinc finger protein 300 pseudogene 1",TRUE
+"218490_s_at",0.682825347106105,0.15097261519706,-1.48751646173659,-4.91585033953452,-0.720968951509649,"ZNF302","zinc finger protein 302",TRUE
+"228393_s_at",0.855405088766616,0.468410715870638,-0.737746124938582,-5.67801093509277,-0.346847780614068,"ZNF302","zinc finger protein 302",TRUE
+"228392_at",0.898197048519062,0.58722299937819,-0.550887789507371,-5.79294208936609,-0.289797118767913,"ZNF302","zinc finger protein 302",TRUE
+"207753_at",0.817198365370225,0.369611310054692,-0.91584059279585,-5.53920691012661,-0.366075375999952,"ZNF304","zinc finger protein 304",TRUE
+"236550_s_at",0.812302873476553,0.36042921176548,0.933886230017125,-5.52359430576051,0.688950894104396,"ZNF311","zinc finger protein 311",TRUE
+"236551_at",0.944793138991092,0.751658196045319,0.320412070951095,-5.88980301722724,0.206688853838474,"ZNF311","zinc finger protein 311",TRUE
+"227170_at",0.805859691692007,0.346206461786073,-0.96245849207952,-5.49830284168626,-0.269774888528531,"ZNF316","zinc finger protein 316",TRUE
+"235910_x_at",0.976371465776674,0.886317075870017,0.144621623077125,-5.92950148539875,0.0560579990377863,"ZNF316","zinc finger protein 316",TRUE
+"243075_at",0.983783029912313,0.920857028492988,0.100492623728699,-5.93476594020947,0.0349699978009661,"ZNF316","zinc finger protein 316",TRUE
+"1555337_a_at",0.717937808890208,0.19369591291667,1.34040895280324,-5.10053096821824,0.481651515564755,"ZNF317","zinc finger protein 317",TRUE
+"225296_at",0.75067385436597,0.24367543277577,1.19773828347779,-5.2641120164401,0.38894450194895,"ZNF317","zinc finger protein 317",TRUE
+"203520_s_at",0.348854934125219,0.00915989771772565,2.85530702603462,-2.59783788620884,0.867270971074936,"ZNF318","zinc finger protein 318",TRUE
+"203521_s_at",0.432151440378733,0.0192437035458917,2.5245259917064,-3.23660317753783,0.909909272005553,"ZNF318","zinc finger protein 318",TRUE
+"228460_at",0.973071267819624,0.870578568699055,-0.164822000232816,-5.92646043727098,-0.0706835691837746,"ZNF319","zinc finger protein 319",TRUE
+"209538_at",0.471777506776789,0.0257185054030492,-2.39107025492925,-3.48307673290366,-0.906313290553657,"ZNF32","zinc finger protein 32",TRUE
+"1557881_at",0.886404465314046,0.549257793936037,0.608171609044526,-5.76112022414255,0.603824236880199,"ZNF32-AS3","ZNF32 antisense RNA 3",TRUE
+"1562812_at",0.958931830316768,0.814001243813301,0.23808751517704,-5.91211163619928,0.188092096901055,"ZNF32-AS3","ZNF32 antisense RNA 3",TRUE
+"241704_x_at",0.779793852551727,0.300949795751147,-1.05913247530698,-5.40760286504677,-0.839713080939145,"ZNF320","zinc finger protein 320",TRUE
+"229614_at",0.937462538530338,0.722834507928026,-0.359215586380509,-5.87702956378663,-0.520214748865458,"ZNF320","zinc finger protein 320",TRUE
+"219376_at",0.953393289289654,0.785286264654955,-0.275762268426622,-5.90271257159292,-0.0951536917053701,"ZNF322","zinc finger protein 322",TRUE
+"227980_at",0.97922824128613,0.89881915623597,0.128619420399793,-5.93162922787834,0.0383425598220413,"ZNF322","zinc finger protein 322",TRUE
+"205182_s_at",0.881212599079924,0.537873077222356,0.625748242022761,-5.75074727588318,0.589947925690708,"ZNF324","zinc finger protein 324",TRUE
+"236406_at",0.80861715520522,0.351748447026611,0.95123240653193,-5.50832318128841,0.715620926103695,"ZNF324B","zinc finger protein 324B",TRUE
+"222318_at",0.883154480220886,0.5409573578893,0.620967069260106,-5.75359710820455,0.202324994289223,"ZNF324B","zinc finger protein 324B",TRUE
+"234093_at",0.819203514175924,0.376050526510794,0.90336268571901,-5.54983818165991,0.301737154712784,"ZNF326","zinc finger protein 326",TRUE
+"236196_at",0.916912399329188,0.648544373311574,0.462058433611368,-5.8362280862044,0.246574984084402,"ZNF326","zinc finger protein 326",TRUE
+"241720_at",0.925271562705333,0.676410533581819,0.422947234134702,-5.85292909656839,0.154255290158066,"ZNF326","zinc finger protein 326",TRUE
+"227680_at",0.96037751636593,0.820230927796304,-0.229962208753012,-5.91395908135542,-0.0785644020307874,"ZNF326","zinc finger protein 326",TRUE
+"219765_at",0.906476756086155,0.613829368744307,0.511836403151449,-5.81288366269059,0.299763783053562,"ZNF329","zinc finger protein 329",TRUE
+"213760_s_at",0.641209837140528,0.111676672239896,-1.65669024178193,-4.68458760386246,-0.576224593559189,"ZNF330","zinc finger protein 330",TRUE
+"209814_at",0.746836086007095,0.238752571453881,-1.21073906387703,-5.24986132281011,-0.417752799082372,"ZNF330","zinc finger protein 330",TRUE
+"219228_at",0.615637099066718,0.0860362375143511,-1.7966653280991,-4.47898856969339,-0.590475131423089,"ZNF331","zinc finger protein 331",TRUE
+"227613_at",0.635821858586292,0.106744187932413,-1.68132186510057,-4.64931486344628,-0.699099270693615,"ZNF331","zinc finger protein 331",TRUE
+"1569250_at",0.591843008270235,0.0690294076586975,1.91098971308741,-4.3021407708233,1.28971886027483,"ZNF333","zinc finger protein 333",TRUE
+"1559674_at",0.713633547141264,0.188687046307544,1.35622956012381,-5.08143381924835,0.55332150846351,"ZNF333","zinc finger protein 333",TRUE
+"1569251_a_at",0.728622545366091,0.210076796607025,1.2908091383839,-5.15917807134179,0.779454444279405,"ZNF333","zinc finger protein 333",TRUE
+"1552375_at",0.768852835478002,0.273439615229207,1.12304690467441,-5.34337196038722,0.78850342027264,"ZNF333","zinc finger protein 333",TRUE
+"1563783_a_at",0.907189812622248,0.616058067803746,0.508602361586788,-5.81447110653236,0.318838703105163,"ZNF333","zinc finger protein 333",TRUE
+"231369_at",0.909069952277897,0.6229394573762,0.498651240686801,-5.81929407704585,0.398720530914084,"ZNF333","zinc finger protein 333",TRUE
+"238566_at",0.933005936987066,0.704153533796247,0.384664338432409,-5.86787022953437,0.317650936287183,"ZNF334","zinc finger protein 334",TRUE
+"220022_at",0.939166148226364,0.72753269907147,-0.352853846330012,-5.87922255549006,-0.49611794069261,"ZNF334","zinc finger protein 334",TRUE
+"221890_at",0.6181505942496,0.0891384889590008,-1.77796370651571,-4.50717030855579,-0.717412724403489,"ZNF335","zinc finger protein 335",TRUE
+"222059_at",0.795745814800525,0.327976807252489,1.00027556195181,-5.46375915942478,0.69572246977402,"ZNF335","zinc finger protein 335",TRUE
+"78330_at",0.967438733768155,0.847495996154411,-0.194578519603667,-5.92125968734241,-0.0749760359701384,"ZNF335","zinc finger protein 335",TRUE
+"214760_at",0.345766760173066,0.00879673641336507,-2.87296371659809,-2.56276813658938,-1.14661044920189,"ZNF337","zinc finger protein 337",TRUE
+"37860_at",0.863719378931144,0.489173042155467,-0.703334054460409,-5.70157382302221,-0.211751762022914,"ZNF337","zinc finger protein 337",TRUE
+"232873_at",0.902212740485572,0.600683501565521,0.531026714162916,-5.80326235951702,0.23937742451195,"ZNF33A","zinc finger protein 33A",TRUE
+"231864_at",0.9089753392553,0.621809650842551,0.500281520551607,-5.81851030616762,0.181774187566679,"ZNF33A","zinc finger protein 33A",TRUE
+"224276_at",0.971216837324271,0.862742398889525,0.174905428739096,-5.9247942648265,0.0754960217919898,"ZNF33A","zinc finger protein 33A",TRUE
+"215022_x_at",0.806196632812812,0.346631375293344,0.961593465284996,-5.49907878318299,0.391647596323111,"ZNF33B","zinc finger protein 33B",TRUE
+"1558586_at",0.912241810302154,0.632081872157216,0.485508758215294,-5.82552116035148,0.192529383472435,"ZNF33B","zinc finger protein 33B",TRUE
+"1562743_at",0.996261754016157,0.981477041048074,-0.0234806752203407,-5.9394149459036,-0.013790216789892,"ZNF33B","zinc finger protein 33B",TRUE
+"219801_at",0.994825233837873,0.975859134388748,-0.0306042822158434,-5.9392272969588,-0.0135248099561487,"ZNF34","zinc finger protein 34",TRUE
+"233362_at",0.716617653514423,0.192592223150268,1.34386711416173,-5.09637263290798,0.843944005398944,"ZNF341","zinc finger protein 341",TRUE
+"1553532_a_at",0.900831880406409,0.596633084515501,-0.536980073724908,-5.80020752356775,-0.317107082937355,"ZNF341","zinc finger protein 341",TRUE
+"240449_at",0.916349280948806,0.646809024230941,-0.464517793827389,-5.83512954595986,-0.150090789096357,"ZNF341","zinc finger protein 341",TRUE
+"207296_at",0.798030358990077,0.332260870453591,0.99126077782491,-5.47210359457874,0.597790467976344,"ZNF343","zinc finger protein 343",TRUE
+"227986_at",0.953774206775359,0.786711528475094,-0.273883100988292,-5.90321382210609,-0.121991957820063,"ZNF343","zinc finger protein 343",TRUE
+"240199_x_at",0.595936234743389,0.072410111426129,-1.886443001124,-4.34076152211743,-1.19664890937191,"ZNF345","zinc finger protein 345",TRUE
+"207236_at",0.86655256862895,0.497600081292629,0.68960838903817,-5.71067295845779,0.415926947279644,"ZNF345","zinc finger protein 345",TRUE
+"232753_at",0.499515085498997,0.0316199672777691,-2.29421879782825,-3.65727547655144,-1.0958447322612,"ZNF346","zinc finger protein 346",TRUE
+"222884_at",0.716219454102037,0.191917261024395,-1.34598963121016,-5.09381592201898,-0.414066301483839,"ZNF346","zinc finger protein 346",TRUE
+"236267_at",0.803988341675731,0.342645435627113,-0.969736526052829,-5.49174910022063,-0.345964754280318,"ZNF346","zinc finger protein 346",TRUE
+"238819_at",0.856692622546542,0.470894986472633,0.733582170526805,-5.6809189728152,0.66221177048294,"ZNF347","zinc finger protein 347",TRUE
+"237061_at",0.884332704164424,0.543419137912543,0.617161323067171,-5.75585048068709,0.817196500022178,"ZNF347","zinc finger protein 347",TRUE
+"206096_at",0.864079461576774,0.491144245027749,-0.70011136379192,-5.70372560371056,-0.244760146190449,"ZNF35","zinc finger protein 35",TRUE
+"219266_at",0.7994347047598,0.334846998899985,-0.98585769934879,-5.47707197735639,-0.483090717992622,"ZNF350","zinc finger protein 350",TRUE
+"233169_at",0.894771301727207,0.57211357909614,-0.573452471626888,-5.78077075537962,-0.340965685282991,"ZNF350","zinc finger protein 350",TRUE
+"205427_at",0.617775129514679,0.0886968477230803,-1.7805915251464,-4.50322339980261,-0.710371160545719,"ZNF354A","zinc finger protein 354A",TRUE
+"1553612_at",0.950887541143339,0.77569716975115,0.28843198057445,-5.89924427011766,0.0880500845311527,"ZNF354B","zinc finger protein 354B",TRUE
+"234409_at",0.812302873476553,0.35742362225651,0.939859922933987,-5.51836433666694,0.650704171162649,"ZNF354C","zinc finger protein 354C",TRUE
+"228208_x_at",0.879419229950485,0.533578938145069,0.632429489840334,-5.74672965227934,0.323594259397888,"ZNF354C","zinc finger protein 354C",TRUE
+"226260_x_at",0.936992192746977,0.719135459313528,0.364235042185506,-5.87527196677989,0.13131751740676,"ZNF358","zinc finger protein 358",TRUE
+"219379_x_at",0.984161165881616,0.922475741021068,0.0984302236618824,-5.93496566675053,0.0428134130883215,"ZNF358","zinc finger protein 358",TRUE
+"228957_at",0.812896635201594,0.361963135203317,0.93085039361778,-5.52624043735659,0.297725027664543,"ZNF362","zinc finger protein 362",TRUE
+"226820_at",0.970190697775564,0.858400975908137,0.180499818034321,-5.92382732145727,0.0822981153207643,"ZNF362","zinc finger protein 362",TRUE
+"214915_at",0.994881960699796,0.97601241166924,-0.0304099040367177,-5.93923307318387,-0.0164171763742926,"ZNF362","zinc finger protein 362",TRUE
+"206448_at",0.499265335405817,0.0314170796117606,2.29726136044273,-3.65186618566722,2.05753539397715,"ZNF365","zinc finger protein 365",TRUE
+"1570121_at",0.837712946644982,0.422372799271371,0.817453865375038,-5.61935078562127,0.325400067841129,"ZNF365","zinc finger protein 365",TRUE
+"1556314_a_at",0.773234064853267,0.284447699373212,1.09693809669137,-5.37001471420471,0.531779404775436,"ZNF366","zinc finger protein 366",TRUE
+"236570_at",0.956960361976289,0.805007986676388,0.249846443545554,-5.90932507240135,0.145288935572912,"ZNF366","zinc finger protein 366",TRUE
+"229551_x_at",0.822178297049143,0.386721424582273,-0.882990946315648,-5.56690512397547,-0.338238757331878,"ZNF367","zinc finger protein 367",TRUE
+"215358_x_at",0.68806049531767,0.157373434708425,1.46350147902992,-4.94707101021238,0.861319673668082,"ZNF37BP","zinc finger protein 37B, pseudogene",TRUE
+"242208_at",0.966313390701604,0.842714662626919,-0.200763924943403,-5.92007088562694,-0.0743277778234308,"ZNF37BP","zinc finger protein 37B, pseudogene",TRUE
+"236310_at",0.993225426079816,0.968467911680333,-0.0399790196764785,-5.93890502700999,-0.0188832454324421,"ZNF37BP","zinc finger protein 37B, pseudogene",TRUE
+"1561687_a_at",0.778481681746654,0.298441061975706,-1.06478254058011,-5.40206023834333,-1.3610457588178,"ZNF382","zinc finger protein 382",TRUE
+"1557260_a_at",0.835952408568777,0.415768840723366,-0.829320275281727,-5.61013469926266,-0.947770773170693,"ZNF382","zinc finger protein 382",TRUE
+"235414_at",0.786455312223125,0.311961279715856,-1.0347210678551,-5.43124546306114,-0.341526570946366,"ZNF383","zinc finger protein 383",TRUE
+"220616_at",0.793899058670723,0.325705528761646,1.0050880576446,-5.4592764596299,0.419008588804755,"ZNF384","zinc finger protein 384",TRUE
+"212369_at",0.961212424803935,0.823216698116511,0.226073540875614,-5.91482066567527,0.0724120625349975,"ZNF384","zinc finger protein 384",TRUE
+"226111_s_at",0.850206060456713,0.452783749915853,-0.764245362926646,-5.65913902912252,-0.382792179688293,"ZNF385A","zinc finger protein 385A",TRUE
+"229019_at",0.769017612409316,0.274376495040212,1.1207953434766,-5.34569144681081,1.25054888446649,"ZNF385B","zinc finger protein 385B",TRUE
+"1555800_at",0.87799769105223,0.529769434436453,0.638381042671218,-5.74311624916528,1.12136440736661,"ZNF385B","zinc finger protein 385B",TRUE
+"1555801_s_at",0.961123450264505,0.822501759623198,0.22700435008417,-5.91461576390924,0.36438577124543,"ZNF385B","zinc finger protein 385B",TRUE
+"241383_at",0.773107052530371,0.283932236738955,1.09814414169806,-5.36879626722267,0.648043697857663,"ZNF385C","zinc finger protein 385C",TRUE
+"220117_at",0.687545925823023,0.156518980424321,1.46666089840612,-4.94298708639632,0.885086000405415,"ZNF385D","zinc finger protein 385D",TRUE
+"230773_at",0.905462783815257,0.611748048898701,-0.514861584951242,-5.81138985839686,-0.237904385087452,"ZNF385D","zinc finger protein 385D",TRUE
+"215523_at",0.580630437263151,0.0631160768931772,1.95658517850565,-4.22948747135324,1.01425492778414,"ZNF391","zinc finger protein 391",TRUE
+"1562446_at",0.767727587789514,0.269862767810499,1.13169522238123,-5.33442448755968,0.477704522526029,"ZNF391","zinc finger protein 391",TRUE
+"1556236_at",0.961475152596758,0.825295369206061,0.223368386064934,-5.91541140375938,0.101054045369761,"ZNF391","zinc finger protein 391",TRUE
+"1558658_at",0.96200396340887,0.82728590194671,-0.220779530257834,-5.91597011763929,-0.17567492904138,"ZNF391","zinc finger protein 391",TRUE
+"214714_at",0.95522318970695,0.795276810159312,-0.262610964037629,-5.90614911763433,-0.100847884051625,"ZNF394","zinc finger protein 394",TRUE
+"243024_at",0.966641191718519,0.845058644832342,0.197730630076842,-5.92065849933038,0.0507386583543923,"ZNF394","zinc finger protein 394",TRUE
+"232694_at",0.579036829255831,0.0619534977639536,1.96599005164827,-4.21435559554614,1.54007039316101,"ZNF395","zinc finger protein 395",TRUE
+"218149_s_at",0.917166618334994,0.649911484164138,-0.460122981592168,-5.83708859160173,-0.20842547793003,"ZNF395","zinc finger protein 395",TRUE
+"222536_s_at",0.954577684533304,0.791932157139055,0.267008397774477,-5.90501858628115,0.208728912906229,"ZNF395","zinc finger protein 395",TRUE
+"1555166_a_at",0.663566587754224,0.131536070929681,-1.56593254821323,-4.81108397465228,-1.32870974799989,"ZNF396","zinc finger protein 396",TRUE
+"1552825_at",0.7768734672127,0.294449331037735,-1.07384287220467,-5.39311708808988,-0.491891891984607,"ZNF396","zinc finger protein 396",TRUE
+"1554231_a_at",0.817560991958296,0.37001824828726,-0.91504778260701,-5.53988639293566,-0.684300983492629,"ZNF396","zinc finger protein 396",TRUE
+"1570030_at",0.881038735550884,0.536970348143797,0.627150408219602,-5.74990751903985,0.566556102284789,"ZNF396","zinc finger protein 396",TRUE
+"1554985_at",0.922635094827638,0.669274372871196,-0.432896977381616,-5.84881785464581,-0.205002579923829,"ZNF396","zinc finger protein 396",TRUE
+"239339_at",0.246981768922011,0.00339695902311608,-3.28014442583116,-1.73255903386069,-2.09717000649606,"ZNF397","zinc finger protein 397",TRUE
+"235271_s_at",0.670609044001682,0.13624371761812,-1.54610645389585,-4.83797541610941,-1.16832640380463,"ZNF397","zinc finger protein 397",TRUE
+"228927_at",0.812505689959838,0.36115873493504,-0.93244132991349,-5.52485471431116,-0.597476606793337,"ZNF397","zinc finger protein 397",TRUE
+"235270_at",0.896732654614547,0.5817322455697,0.559053766377703,-5.78859210344383,0.462841111521235,"ZNF397","zinc finger protein 397",TRUE
+"229133_s_at",0.923573053923573,0.671952843544043,-0.429157308342482,-5.85037410429753,-0.385837687884941,"ZNF397","zinc finger protein 397",TRUE
+"226202_at",0.236926796662401,0.00307725794401411,-3.32171100774498,-1.64585958151466,-1.24554693539826,"ZNF398","zinc finger protein 398",TRUE
+"228145_s_at",0.413914506615876,0.0166901598627106,-2.58907489353478,-3.11490466856868,-1.23108015988071,"ZNF398","zinc finger protein 398",TRUE
+"1555015_a_at",0.567651250567208,0.0576117250766669,-2.00255350497761,-4.15506153993524,-0.864681223694905,"ZNF398","zinc finger protein 398",TRUE
+"239043_at",0.951008334819225,0.776356762987129,0.287558963110332,-5.89948821443597,0.352001842837443,"ZNF404","zinc finger protein 404",TRUE
+"220836_at",0.750807729565285,0.24374632069476,1.19755252385168,-5.26431466652348,1.21567980512128,"ZNF407","zinc finger protein 407",TRUE
+"220835_s_at",0.846321019035727,0.444374646812577,-0.778733260825069,-5.64855514269535,-0.461774030747429,"ZNF407","zinc finger protein 407",TRUE
+"234844_at",0.892625092437988,0.564944289978742,-0.584264612355385,-5.77477099162569,-0.467317154935287,"ZNF407","zinc finger protein 407",TRUE
+"227768_at",0.899808883319249,0.593651244776811,-0.541375394098356,-5.79793090908941,-0.172045095869956,"ZNF407","zinc finger protein 407",TRUE
+"219224_x_at",0.84772210282622,0.446837995179294,-0.77447208426553,-5.65168754574448,-0.27562967561453,"ZNF408","zinc finger protein 408",TRUE
+"1553217_s_at",0.768852835478002,0.274134271117504,-1.12137693052204,-5.34509270897242,-0.407478173911754,"ZNF41","zinc finger protein 41",TRUE
+"1553216_at",0.784552021081681,0.308030621589273,-1.04336390276189,-5.42293151812014,-0.335567054285019,"ZNF41","zinc finger protein 41",TRUE
+"214904_at",0.988139605576153,0.943345973420731,0.0718753435249941,-5.93716759417181,0.0292609514158588,"ZNF41","zinc finger protein 41",TRUE
+"239145_at",0.755940660414394,0.250495029937427,-1.18005017487413,-5.28328557564746,-0.470912454064226,"ZNF414","zinc finger protein 414",TRUE
+"227071_at",0.806248215548257,0.347105472116978,0.960629163758952,-5.49994302364349,0.363053745881879,"ZNF414","zinc finger protein 414",TRUE
+"205514_at",0.984441970220849,0.924129315610537,0.0963238573198983,-5.93516538017423,0.122759076293074,"ZNF415","zinc finger protein 415",TRUE
+"223589_at",0.659382629906731,0.127310135180179,-1.58423695563872,-4.78601772933524,-0.976006665289803,"ZNF416","zinc finger protein 416",TRUE
+"234902_s_at",0.862634144901168,0.48561479338732,-0.709170379596241,-5.69765295441873,-0.26294919158176,"ZNF416","zinc finger protein 416",TRUE
+"1552783_at",0.877223961993707,0.526530962368721,-0.643458782937317,-5.74000764964927,-0.613279364878675,"ZNF417","zinc finger protein 417",TRUE
+"1558251_a_at",0.800342373547779,0.336045651545862,-0.983363158211608,-5.47935748630455,-0.477004633978967,"ZNF417///ZNF587","zinc finger protein 417///zinc finger protein 587",TRUE
+"1558253_x_at",0.99176128617116,0.961880314077635,-0.0483375401323296,-5.93854551315852,-0.0161236241936695,"ZNF417///ZNF587","zinc finger protein 417///zinc finger protein 587",TRUE
+"243439_at",0.862634144901168,0.485845092886836,0.70879189082526,-5.69790816088361,0.340475782359182,"ZNF418","zinc finger protein 418",TRUE
+"219826_at",0.822452640841017,0.387308042725677,-0.881881765709472,-5.56782401524497,-0.332095007576029,"ZNF419","zinc finger protein 419",TRUE
+"58367_s_at",0.95168059103032,0.778455644773842,-0.284782461430837,-5.9002591659406,-0.0842655104282457,"ZNF419","zinc finger protein 419",TRUE
+"238937_at",0.335661229817476,0.00829407080902441,-2.89858654812562,-2.51171990223795,-1.42441198580306,"ZNF420","zinc finger protein 420",TRUE
+"242761_s_at",0.399719600134805,0.0142079539362942,-2.66139554561562,-2.97676124253497,-1.34235094631554,"ZNF420","zinc finger protein 420",TRUE
+"214761_at",0.878278790222455,0.531013871623376,-0.636434326714212,-5.74430175283889,-0.60803809744463,"ZNF423","zinc finger protein 423",TRUE
+"242684_at",0.62282585384278,0.093375464544111,-1.75330625802611,-4.54399666327635,-0.744893249572657,"ZNF425","zinc finger protein 425",TRUE
+"235565_at",0.968396410536907,0.851444942795248,0.189475798191446,-5.92221250183816,0.113881154354935,"ZNF425","zinc finger protein 425",TRUE
+"205964_at",0.743323328391634,0.233509300385161,1.22481029745529,-5.23428708431003,1.70072703357376,"ZNF426","zinc finger protein 426",TRUE
+"233354_at",0.827825169467994,0.396916215167809,0.86386787448255,-5.58259728464704,0.453438013899405,"ZNF426","zinc finger protein 426",TRUE
+"215429_s_at",0.640067422642767,0.110585339581287,-1.66205976073381,-4.67693214337206,-0.980046441666719,"ZNF428","zinc finger protein 428",TRUE
+"1565848_at",0.974982245454858,0.878538241667738,0.154597522684015,-5.92804918026638,0.0594067448523417,"ZNF428","zinc finger protein 428",TRUE
+"1561270_at",0.853460708803218,0.462113926421004,-0.748359334948763,-5.67052826017314,-0.349387839914287,"ZNF429","zinc finger protein 429",TRUE
+"206695_x_at",0.488294327273387,0.028971683542293,-2.33542394882569,-3.58366567099523,-1.22556184283156,"ZNF43","zinc finger protein 43",TRUE
+"206829_x_at",0.392184803070819,0.0133059498801348,-2.69066002953614,-2.92034746415427,-0.993878599900741,"ZNF430","zinc finger protein 430",TRUE
+"238614_x_at",0.557589172116298,0.052541370182774,-2.04848948481054,-4.0795369763796,-0.872811361188794,"ZNF430","zinc finger protein 430",TRUE
+"232338_at",0.36270015472629,0.0104680538483418,-2.79680026774356,-2.7133960943188,-1.28676277843713,"ZNF431","zinc finger protein 431",TRUE
+"244663_at",0.478053785909413,0.0266328638661193,-2.37480246482422,-3.51262089787804,-1.51695508026116,"ZNF431","zinc finger protein 431",TRUE
+"243491_at",0.520481716530016,0.0377379550916903,-2.20995148746308,-3.80539573356728,-1.11246816952751,"ZNF431","zinc finger protein 431",TRUE
+"219848_s_at",0.784925710185113,0.310178911823839,-1.0386306044673,-5.42749241171684,-0.516491036369059,"ZNF432","zinc finger protein 432",TRUE
+"226113_at",0.643515428391208,0.11405564294031,-1.64513691739394,-4.70099531037474,-0.61254808252335,"ZNF436","zinc finger protein 436",TRUE
+"226114_at",0.756313947022433,0.251438384578284,-1.17763182178954,-5.28588768073865,-0.481843720585802,"ZNF436","zinc finger protein 436",TRUE
+"229086_at",0.915569510513076,0.644172435855821,0.468259982210616,-5.83344703974937,0.180607812495739,"ZNF436-AS1","ZNF436 antisense RNA 1",TRUE
+"229743_at",0.713724591137462,0.188942839179216,1.35541367438167,-5.0824232637178,0.713748444342777,"ZNF438","zinc finger protein 438",TRUE
+"244752_at",0.870433264908839,0.508906569617136,0.671398717139888,-5.72248014765904,0.232313292274535,"ZNF438","zinc finger protein 438",TRUE
+"236562_at",0.903919439852106,0.605724705601405,0.523644086845708,-5.80700455033145,0.655280765536809,"ZNF439","zinc finger protein 439",TRUE
+"223968_at",0.299994279961527,0.00555647497083842,3.07133635612551,-2.16305669286094,1.32845344932957,"ZNF44","zinc finger protein 44",TRUE
+"228718_at",0.785175995766517,0.310688383400288,-1.0375114901454,-5.42856803424711,-0.745225815573813,"ZNF44","zinc finger protein 44",TRUE
+"215892_at",0.524469554180848,0.0390676770926064,2.19329730119756,-3.8342728244857,1.18813015316699,"ZNF440","zinc finger protein 440",TRUE
+"241731_x_at",0.807944276806637,0.349692728435479,0.955382458581467,-5.50463140359035,0.458562246461477,"ZNF440","zinc finger protein 440",TRUE
+"216291_at",0.980570785147084,0.909274899702237,-0.115262994861617,-5.9332146462839,-0.0667333944773469,"ZNF440","zinc finger protein 440",TRUE
+"1553193_at",0.910159094731364,0.625909888768339,0.494371501741352,-5.82133971164746,0.522070531128493,"ZNF441","zinc finger protein 441",TRUE
+"1553192_at",0.986342822130003,0.935046221317774,-0.0824283554001034,-5.93637470433068,-0.0830443609757632,"ZNF441","zinc finger protein 441",TRUE
+"208081_s_at",0.653206225743412,0.122570940494127,-1.60537558785353,-4.75678759107189,-1.10951889845819,"ZNF442","zinc finger protein 442",TRUE
+"216788_at",0.80110325033185,0.337602317918138,-0.980132664982239,-5.48230944186652,-0.786454704631189,"ZNF443","zinc finger protein 443",TRUE
+"216780_at",0.816800680706682,0.368869241785886,-0.917287808507105,-5.53796516617131,-0.651860891259602,"ZNF443","zinc finger protein 443",TRUE
+"205928_at",0.996666735634539,0.983414303685636,0.0210244990962822,-5.93946818674016,0.0103742179948831,"ZNF443","zinc finger protein 443",TRUE
+"218707_at",0.484495305292367,0.0278419688070528,-2.35406419344681,-3.55011970918032,-1.54974638391624,"ZNF444","zinc finger protein 444",TRUE
+"50376_at",0.627092759817312,0.0983273915386797,-1.72567524568356,-4.58481228138131,-0.559541430531375,"ZNF444","zinc finger protein 444",TRUE
+"229766_at",0.941284052518374,0.737050806701722,0.340010579823766,-5.8835318115923,0.142559636466455,"ZNF445","zinc finger protein 445",TRUE
+"233992_x_at",0.97689149311934,0.889264360238974,0.140845881359265,-5.93002595203267,0.0376236135804593,"ZNF445","zinc finger protein 445",TRUE
+"219900_s_at",0.778170595080965,0.29759766638835,-1.06668960880111,-5.40018347091412,-0.484423269443503,"ZNF446","zinc finger protein 446",TRUE
+"1554160_a_at",0.91876780831279,0.655057035602779,-0.452854194153149,-5.84028869546029,-0.342848181062085,"ZNF446","zinc finger protein 446",TRUE
+"228968_at",0.468735421183467,0.024875164809114,-2.40655529157868,-3.45485022449086,-0.624696624924486,"ZNF449","zinc finger protein 449",TRUE
+"241066_at",0.686108994812404,0.154846605561497,-1.47288533066248,-4.93492041495986,-0.902710059887573,"ZNF449","zinc finger protein 449",TRUE
+"207304_at",0.625932126245264,0.0969241904264908,-1.73338180881338,-4.57347678147598,-0.815353318008721,"ZNF45","zinc finger protein 45",TRUE
+"222028_at",0.730819267705703,0.213473592297731,-1.28090249571688,-5.1706670356884,-0.501730497892423,"ZNF45","zinc finger protein 45",TRUE
+"1556060_a_at",0.586972146297368,0.0662644972396243,1.93186241515851,-4.26902796494388,0.782992549106503,"ZNF451","zinc finger protein 451",TRUE
+"232029_at",0.718706241731185,0.194426122603557,1.33812949712703,-5.10326702932191,0.528154777265457,"ZNF451","zinc finger protein 451",TRUE
+"231885_at",0.752908639736305,0.245970811576953,1.19174379845913,-5.27063775769957,0.622989376082224,"ZNF451","zinc finger protein 451",TRUE
+"215012_at",0.897949253801113,0.585964203983983,0.552756536245764,-5.79195209776754,0.298389185554687,"ZNF451","zinc finger protein 451",TRUE
+"212557_at",0.949038895598021,0.770296274898627,0.295589125809834,-5.89721671971992,0.101335854163297,"ZNF451","zinc finger protein 451",TRUE
+"216273_at",0.834881450121645,0.413488240604367,-0.833445773682534,-5.60690150225954,-0.626994320317464,"ZNF460","zinc finger protein 460",TRUE
+"216279_at",0.89961817630669,0.59046760340565,-0.546080116835286,-5.79547404768396,-0.141554868979448,"ZNF460","zinc finger protein 460",TRUE
+"233175_at",0.929088231432081,0.687504787577301,-0.407564166675155,-5.85910038952952,-0.129716819590903,"ZNF460","zinc finger protein 460",TRUE
+"232391_at",0.807518027624374,0.348676462664037,-0.957440192676455,-5.50279544204822,-0.770916716348378,"ZNF461","zinc finger protein 461",TRUE
+"232393_at",0.705559553212919,0.177584756231417,1.39251509825959,-5.03692879735634,0.555386867846955,"ZNF462","zinc finger protein 462",TRUE
+"226575_at",0.80613219453588,0.346574181339925,0.961709857055145,-5.49897441522521,0.952860898976871,"ZNF462","zinc finger protein 462",TRUE
+"244007_at",0.869850840015332,0.50767151906519,0.673376664533266,-5.72121227512548,0.458779850053304,"ZNF462","zinc finger protein 462",TRUE
+"214746_s_at",0.249014722180944,0.00346461515569619,-3.27183735842704,-1.74984929245632,-2.47025342934045,"ZNF467","zinc finger protein 467",TRUE
+"213559_s_at",0.774230543658252,0.288636295477494,-1.08719597126746,-5.37981330647971,-0.73938275037792,"ZNF467","zinc finger protein 467",TRUE
+"214751_at",0.64513208805899,0.116201182827969,-1.63488982044743,-4.71547431976515,-0.84744876451516,"ZNF468","zinc finger protein 468",TRUE
+"230440_at",0.95168059103032,0.778345266406007,0.284928418109657,-5.90021882294595,0.193252070806578,"ZNF469","zinc finger protein 469",TRUE
+"234921_at",0.73759219552868,0.224021278061723,1.25089443399184,-5.20500643620111,0.99483130332189,"ZNF470","zinc finger protein 470",TRUE
+"211923_s_at",0.811108294782947,0.355122274540726,0.944456800859924,-5.51431893149692,0.74772841851342,"ZNF471","zinc finger protein 471",TRUE
+"232117_at",0.813583749541436,0.364196840786953,0.92644496367542,-5.53006625803136,0.871565135914247,"ZNF471","zinc finger protein 471",TRUE
+"230578_at",0.973433731874338,0.871565697733782,-0.163553043834896,-5.92666312997761,-0.17410428329965,"ZNF471","zinc finger protein 471",TRUE
+"213124_at",0.517654151778308,0.0367785655835171,-2.22230186371538,-3.783895223312,-0.577943258455822,"ZNF473","zinc finger protein 473",TRUE
+"213130_at",0.593339168375633,0.0704398967300571,-1.90062306166861,-4.31849373112211,-0.559750641702875,"ZNF473","zinc finger protein 473",TRUE
+"1556907_at",0.955615519046701,0.796627677431129,0.260836394510417,-5.90660005838464,0.101643807125563,"ZNF474","zinc finger protein 474",TRUE
+"227470_at",0.787983178144695,0.31410296687174,-1.03004413777888,-5.43571842961539,-0.289931905950214,"ZNF48","zinc finger protein 48",TRUE
+"222283_at",0.741734366005262,0.232247106169642,-1.2282332727382,-5.23047496376432,-0.398146865793597,"ZNF480","zinc finger protein 480",TRUE
+"1559988_at",0.872668627020452,0.516477773578003,-0.659331519406728,-5.73013787398108,-0.383590408588933,"ZNF483","zinc finger protein 483",TRUE
+"243770_at",0.976371465776674,0.885862770818463,-0.145203819668736,-5.9294193837199,-0.100043863832106,"ZNF483","zinc finger protein 483",TRUE
+"1570534_a_at",0.9874689345458,0.94091649787578,0.074963465271588,-5.93694678980916,0.0447089890486874,"ZNF483","zinc finger protein 483",TRUE
+"214922_at",0.884686243932645,0.543966751687749,0.61631599825019,-5.75634918317996,0.306241731516182,"ZNF484","zinc finger protein 484",TRUE
+"1552427_at",0.614663663463974,0.0854739429961882,-1.8001171638277,-4.47376351451352,-0.851234829234308,"ZNF485","zinc finger protein 485",TRUE
+"1553901_x_at",0.708894565317004,0.181485095024402,-1.3795679414108,-5.05292079219351,-0.734033529818864,"ZNF486","zinc finger protein 486",TRUE
+"229901_at",0.163850812837738,0.00131567616917112,3.67514123630444,-0.89843545157643,4.56986753746219,"ZNF488","zinc finger protein 488",TRUE
+"231988_x_at",0.990390614845554,0.95176391220912,0.0611805897744924,-5.93786053644116,0.02309041400685,"ZNF490","zinc finger protein 490",TRUE
+"1562211_a_at",0.926263798296325,0.679784991777638,0.418257459759304,-5.85483433573321,0.153144993219168,"ZNF491","zinc finger protein 491",TRUE
+"215532_x_at",0.85334340854827,0.460959202864655,-0.750314939980377,-5.66913844313179,-0.684534200410205,"ZNF492","zinc finger protein 492",TRUE
+"235604_x_at",0.731054546207485,0.213633410782967,-1.28043939624974,-5.17120225872921,-0.853181559961926,"ZNF493","zinc finger protein 493",TRUE
+"240155_x_at",0.904381089098038,0.60800745722255,0.520310786172307,-5.8086774535836,0.341878290752675,"ZNF493","zinc finger protein 493",TRUE
+"1558486_at",0.975242094553739,0.879867644062456,-0.152891532176177,-5.92830438984387,-0.142898589954076,"ZNF493","zinc finger protein 493",TRUE
+"211064_at",0.998870448604467,0.995746381657623,0.00539161942923383,-5.93966932204809,0.00265693649318699,"ZNF493","zinc finger protein 493",TRUE
+"238145_at",0.650490742096872,0.120627812238138,1.6142402278709,-4.74444021313283,0.639074946608686,"ZNF496","zinc finger protein 496",TRUE
+"225349_at",0.826379603754428,0.394605513467244,-0.86817407418677,-5.57909151877735,-0.349293855770031,"ZNF496","zinc finger protein 496",TRUE
+"1557616_at",0.878788356961452,0.532081501035027,0.634766168169322,-5.74531485153679,0.340142384931538,"ZNF496","zinc finger protein 496",TRUE
+"225335_at",0.918079643145802,0.65213053318636,-0.456985210572935,-5.83847612999771,-0.208890973620978,"ZNF496","zinc finger protein 496",TRUE
+"225333_at",0.946416600885596,0.757811511827671,-0.312194880161518,-5.89232273794524,-0.104067641359944,"ZNF496","zinc finger protein 496",TRUE
+"230857_s_at",0.854040699678541,0.463350987298585,-0.746267517578943,-5.67201107768635,-0.549024592303667,"ZNF497","zinc finger protein 497",TRUE
+"213641_at",0.697699759202153,0.16847132984767,-1.42367463857235,-4.99793640262896,-1.06180296736023,"ZNF500","zinc finger protein 500",TRUE
+"41113_at",0.839508810008021,0.426124696068794,-0.810763979391823,-5.62449162561317,-0.228582756855736,"ZNF500","zinc finger protein 500",TRUE
+"213639_s_at",0.984617370576969,0.924865007786399,-0.0953868575501976,-5.93525283400252,-0.0307368726708148,"ZNF500","zinc finger protein 500",TRUE
+"1562386_s_at",0.923124080520773,0.670559936540779,0.431101299246735,-5.84956677474691,0.409456867352345,"ZNF501","zinc finger protein 501",TRUE
+"229532_at",0.493378740589161,0.0297159033109121,2.32350620673082,-3.60503350787554,2.08683018544965,"ZNF502","zinc finger protein 502",TRUE
+"232247_at",0.559434208511607,0.0539728967864045,2.03513350430425,-4.10161270693176,1.30219959298318,"ZNF502","zinc finger protein 502",TRUE
+"232178_at",0.409854205952965,0.0158094653928633,2.61350188850364,-3.06845212314565,1.71842116159568,"ZNF503","zinc finger protein 503",TRUE
+"227195_at",0.918094485138241,0.652161931665277,-0.456940846099283,-5.8384956814875,-0.517241290030974,"ZNF503","zinc finger protein 503",TRUE
+"228684_at",0.920169584950428,0.660384715937263,0.445354138018863,-5.84353824030349,0.316238194881473,"ZNF503","zinc finger protein 503",TRUE
+"227225_at",0.968271298107834,0.851081588692787,-0.189945097393859,-5.92212592464047,-0.131000747805335,"ZNF503","zinc finger protein 503",TRUE
+"232684_at",0.928777626237599,0.686610395041118,-0.408800562819262,-5.85861269065384,-0.284708915818431,"ZNF503-AS1","ZNF503 antisense RNA 1",TRUE
+"228048_at",0.711031110506526,0.184764482403322,1.36885174250447,-5.06606331494385,0.735032193549314,"ZNF503-AS2","ZNF503 antisense RNA 2",TRUE
+"235929_s_at",0.859781203630624,0.478039499449995,0.721678643819185,-5.68914596280036,0.383184617901939,"ZNF503-AS2","ZNF503 antisense RNA 2",TRUE
+"237044_s_at",0.867083896534332,0.498729846880872,0.687778385479435,-5.71187318530523,0.405166796630072,"ZNF503-AS2","ZNF503 antisense RNA 2",TRUE
+"235928_at",0.88698237223329,0.551047417914798,-0.605426264121775,-5.76271466728163,-0.488339342656672,"ZNF503-AS2","ZNF503 antisense RNA 2",TRUE
+"221625_at",0.769847953580141,0.277644963999618,1.11298402579712,-5.35370645544354,0.703089898969856,"ZNF506","zinc finger protein 506",TRUE
+"1568720_at",0.847515494238763,0.44626229108939,-0.775466671747018,-5.65095787225052,-0.793609365282785,"ZNF506","zinc finger protein 506",TRUE
+"238493_at",0.853768202875953,0.462386279134511,-0.747898511757454,-5.67085525961634,-1.12274737481585,"ZNF506","zinc finger protein 506",TRUE
+"221626_at",0.881466832418197,0.538311431814241,-0.625067822277551,-5.75115412682324,-0.267529873483284,"ZNF506","zinc finger protein 506",TRUE
+"226327_at",0.72050514215489,0.196524502646798,-1.33161623971529,-5.11106341903484,-0.348145657008756,"ZNF507","zinc finger protein 507",TRUE
+"235618_at",0.870235011564094,0.508484644068369,-0.672074132755943,-5.72204760485063,-0.184194955145017,"ZNF507","zinc finger protein 507",TRUE
+"206225_at",0.956398858120188,0.802443692135728,-0.253205861932505,-5.90850445655237,-0.098292196645354,"ZNF507","zinc finger protein 507",TRUE
+"228917_at",0.218155630903764,0.00264063572440293,-3.38584740367925,-1.5115148492785,-1.04255272753109,"ZNF510","zinc finger protein 510",TRUE
+"206053_at",0.6287528932499,0.099764246024386,-1.71788049885648,-4.59623919225672,-0.475545132047691,"ZNF510","zinc finger protein 510",TRUE
+"225307_at",0.943400587031071,0.746053067814913,0.32791683212591,-5.88744513308586,0.142203029976464,"ZNF511","zinc finger protein 511",TRUE
+"225050_at",0.496742810480539,0.0303633191152439,2.3133595718252,-3.62317622468714,1.613113634406,"ZNF512","zinc finger protein 512",TRUE
+"1553218_a_at",0.668739504090464,0.135032174214151,1.55115406447914,-4.83115465466521,1.47204824120279,"ZNF512","zinc finger protein 512",TRUE
+"221869_at",0.213766936771743,0.00256090248898934,-3.39866869418549,-1.4845800224479,-1.43096650880365,"ZNF512B","zinc finger protein 512B",TRUE
+"55872_at",0.234010800532132,0.00302170324966959,-3.32936030633322,-1.62987227724369,-1.3151764124349,"ZNF512B","zinc finger protein 512B",TRUE
+"225753_at",0.990810941805126,0.955904170585582,-0.0559232691153206,-5.938160348451,-0.0372837479029835,"ZNF513","zinc finger protein 513",TRUE
+"235729_at",0.778686132916778,0.299402157161032,1.06261401559787,-5.40419065288061,0.366466665364163,"ZNF514","zinc finger protein 514",TRUE
+"203604_at",0.860714927752408,0.480383503016466,-0.717796000445035,-5.6918017334974,-0.593368952805661,"ZNF516","zinc finger protein 516",TRUE
+"241112_at",0.823274744098629,0.390055697513961,0.876700997812871,-5.5721017867263,0.377595129076571,"ZNF517","zinc finger protein 517",TRUE
+"215644_at",0.731548533938014,0.215030296351956,1.27640302411299,-5.17586027252051,0.88569102396233,"ZNF518A","zinc finger protein 518A",TRUE
+"244132_x_at",0.773156930607264,0.28402239260882,1.09793308679461,-5.36900957841003,0.484157708240518,"ZNF518A","zinc finger protein 518A",TRUE
+"204291_at",0.995517970857919,0.978893676573674,0.0267562504932155,-5.9393347997598,0.0110978050965951,"ZNF518A","zinc finger protein 518A",TRUE
+"241580_at",0.827768017240356,0.396714652157158,0.864242860007311,-5.58229264565283,0.565324037565984,"ZNF518B","zinc finger protein 518B",TRUE
+"230715_at",0.864894115958506,0.493489413761171,0.696286938485238,-5.70626693032142,0.548968779277882,"ZNF518B","zinc finger protein 518B",TRUE
+"226909_at",0.900750978800947,0.596349043084347,0.537398296998041,-5.7999916761669,0.51971351981388,"ZNF518B","zinc finger protein 518B",TRUE
+"1568873_at",0.578441573439199,0.0617076754300272,1.96799862925211,-4.21111752114918,1.09767593907251,"ZNF519","zinc finger protein 519",TRUE
+"1557283_a_at",0.837642003916702,0.422115088798359,-0.81791474248231,-5.61899516650679,-0.488314531400824,"ZNF519","zinc finger protein 519",TRUE
+"1564190_x_at",0.99783553534859,0.989397391388814,0.0134395554719011,-5.93959550698512,0.00741395872292738,"ZNF519","zinc finger protein 519",TRUE
+"226676_at",0.713633547141264,0.188729874916564,-1.35609289179264,-5.08159959494285,-1.61337595783532,"ZNF521","zinc finger protein 521",TRUE
+"226677_at",0.720507507563255,0.196643949400797,-1.33124712494967,-5.11150429307104,-1.72990251969789,"ZNF521","zinc finger protein 521",TRUE
+"238683_at",0.841247691968787,0.431432744084221,-0.801361778307525,-5.63164970631344,-0.591981893786425,"ZNF524","zinc finger protein 524",TRUE
+"228229_at",0.30050033261608,0.00569397978217209,-3.06087217851718,-2.18438544454439,-0.930065158405093,"ZNF526","zinc finger protein 526",TRUE
+"1570238_at",0.857148066512338,0.472038926066511,0.731669141321273,-5.68224976294638,0.418132512070481,"ZNF527","zinc finger protein 527",TRUE
+"244861_at",0.897011777275924,0.582634818698641,-0.557708811737651,-5.78931282906606,-0.360002497631335,"ZNF527","zinc finger protein 527",TRUE
+"215019_x_at",0.983935461205724,0.921262090411758,-0.0999764931972135,-5.93481631137704,-0.0665631002352551,"ZNF528","zinc finger protein 528",TRUE
+"231940_at",0.731054546207485,0.21366059747157,-1.28036064508824,-5.17129325826704,-0.657559742409914,"ZNF529","zinc finger protein 529",TRUE
+"237453_at",0.97304633500821,0.869134929307455,0.166678301216996,-5.92616111239486,0.0811475347986823,"ZNF529","zinc finger protein 529",TRUE
+"215307_at",0.990810941805126,0.954949590639088,0.0571352506883941,-5.93809361898131,0.0573468478039549,"ZNF529","zinc finger protein 529",TRUE
+"237364_at",0.980174445251813,0.906842302368461,0.118368447224691,-5.93286149905332,0.0925971871968558,"ZNF529-AS1","ZNF529 antisense RNA 1",TRUE
+"232228_at",0.740476003158683,0.229208363731011,1.2365324049261,-5.22119423423594,0.694123744481596,"ZNF530","zinc finger protein 530",TRUE
+"244664_at",0.933859583363678,0.707052420152848,-0.380698673819611,-5.86933818417187,-0.213207983779692,"ZNF530","zinc finger protein 530",TRUE
+"225021_at",0.812302873476553,0.360889786915756,0.932973782808957,-5.52439045617112,1.12187206883386,"ZNF532","zinc finger protein 532",TRUE
+"220617_s_at",0.868397087637799,0.503627780091599,0.679871742925444,-5.71702380453827,0.889287603089832,"ZNF532","zinc finger protein 532",TRUE
+"206403_at",0.784918343662568,0.309681092902894,1.03972537603228,-5.426439175517,0.487363477741128,"ZNF536","zinc finger protein 536",TRUE
+"242715_at",0.8920930097751,0.563899788814541,0.585845697897503,-5.77388454225563,0.409329671642687,"ZNF536","zinc finger protein 536",TRUE
+"239340_at",0.906507435035949,0.614360281057413,0.511065501334042,-5.81326295399092,0.327362421567734,"ZNF536","zinc finger protein 536",TRUE
+"242697_at",0.889220679867655,0.556773310554903,0.596673832249435,-5.76775140658193,0.228563655315551,"ZNF540","zinc finger protein 540",TRUE
+"238454_at",0.986889306520757,0.939194724010676,-0.0771524734842022,-5.93678465126572,-0.0486660871370708,"ZNF540","zinc finger protein 540",TRUE
+"232604_at",0.941322235848309,0.737511122396598,-0.339390945691915,-5.88373572108672,-0.167413950938193,"ZNF541","zinc finger protein 541",TRUE
+"239250_at",0.773156930607264,0.284071817577771,1.09781740350529,-5.36912648293999,1.85476761859483,"ZNF542P","zinc finger protein 542, pseudogene",TRUE
+"235121_at",0.774441945744807,0.290782235101877,1.08224423172942,-5.38476387713763,1.46666970498943,"ZNF542P","zinc finger protein 542, pseudogene",TRUE
+"240191_at",0.555886273252387,0.051567538691104,-2.05776218939262,-4.06415467165894,-0.643041334972472,"ZNF543","zinc finger protein 543",TRUE
+"235697_at",0.693742297578797,0.162966197164161,1.44315751893782,-4.97319654607941,0.500300294464288,"ZNF544","zinc finger protein 544",TRUE
+"218735_s_at",0.784448016670989,0.307481082413949,1.0445784405835,-5.42175821008006,0.487712264970641,"ZNF544","zinc finger protein 544",TRUE
+"244466_at",0.863835356219448,0.489877989116419,0.702180690765153,-5.70234500307839,0.54560146711228,"ZNF544","zinc finger protein 544",TRUE
+"240429_at",0.508488499910913,0.0335649367127398,-2.26592512222461,-3.70737622074622,-1.90492047199335,"ZNF546","zinc finger protein 546",TRUE
+"1559134_a_at",0.527546822913581,0.0401551686340944,-2.18005497460633,-3.85713819450142,-1.55668705067843,"ZNF546","zinc finger protein 546",TRUE
+"236253_at",0.961690794738111,0.826467937312536,-0.221843174507619,-5.91574135181446,-0.144289031784083,"ZNF546","zinc finger protein 546",TRUE
+"1559133_at",0.9832781796011,0.918511892770969,0.103481353619891,-5.93446916408351,0.0834317278286818,"ZNF546","zinc finger protein 546",TRUE
+"1558995_at",0.660460734341314,0.128477169762299,1.57913220057728,-4.79303116976927,0.548382233352018,"ZNF547","zinc finger protein 547",TRUE
+"1552794_a_at",0.978252879257852,0.894517653378991,-0.134121089404997,-5.93092575806082,-0.111744811734987,"ZNF547","zinc finger protein 547",TRUE
+"1558622_a_at",0.774360462422895,0.290398377702376,-1.08312804436009,-5.38388175121994,-0.378003627071909,"ZNF548","zinc finger protein 548",TRUE
+"1553719_s_at",0.785461218411795,0.311009600683986,-1.0368065637491,-5.42924502911678,-0.378231245096576,"ZNF548","zinc finger protein 548",TRUE
+"1553718_at",0.955217267938193,0.795254409131753,0.262640398440609,-5.90614161236961,0.0687624344912727,"ZNF548","zinc finger protein 548",TRUE
+"215315_at",0.7994347047598,0.334571977030843,0.986430919957571,-5.47654604566204,0.884682277679392,"ZNF549","zinc finger protein 549",TRUE
+"215124_at",0.751579819725748,0.244837882439192,1.19469722577808,-5.26742614628714,0.624709739375022,"ZNF550","zinc finger protein 550",TRUE
+"228099_at",0.923351546840065,0.670808354678266,0.430754474471056,-5.84971107199232,0.142972615237836,"ZNF550","zinc finger protein 550",TRUE
+"211721_s_at",0.773754791548713,0.285236162536552,1.09509635736575,-5.3718730938351,0.502677700413964,"ZNF551","zinc finger protein 551",TRUE
+"242992_at",0.897699110987203,0.585146429976705,0.55397163077724,-5.79130664011959,0.164779616183503,"ZNF551","zinc finger protein 551",TRUE
+"243195_s_at",0.90934735616805,0.623522258827006,0.497810809670221,-5.81969714574803,0.384553694833521,"ZNF551","zinc finger protein 551",TRUE
+"243194_at",0.973936963444057,0.87391581941592,0.160533059569227,-5.92713923301944,0.10538385403433,"ZNF551","zinc finger protein 551",TRUE
+"232328_at",0.627092759817312,0.0985335940604812,1.72455067781073,-4.58646325178015,0.481576551234651,"ZNF552","zinc finger protein 552",TRUE
+"219741_x_at",0.731054546207485,0.213582162271532,-1.28058786785051,-5.17103068197497,-0.713407883173053,"ZNF552","zinc finger protein 552",TRUE
+"242864_at",0.594972224548427,0.0717442712679788,-1.89119699292193,-4.33330905347515,-0.664156875667932,"ZNF554","zinc finger protein 554",TRUE
+"232214_x_at",0.722442821599878,0.199062040505449,1.32381217242749,-5.12036275837874,0.995012031426687,"ZNF554","zinc finger protein 554",TRUE
+"1556187_at",0.280199223932988,0.00461333450810942,-3.15066287626662,-2.00056936182818,-2.54178178435119,"ZNF555","zinc finger protein 555",TRUE
+"1553286_at",0.807528762746328,0.348795167036522,-0.957199630343994,-5.50301026432514,-0.288927608945126,"ZNF555","zinc finger protein 555",TRUE
+"239839_at",0.848376789225697,0.448560085095821,-0.771501639966245,-5.65386153390535,-0.431937845856225,"ZNF555","zinc finger protein 555",TRUE
+"1556188_a_at",0.860714927752408,0.480485180763084,0.717627830128396,-5.6919164559068,0.266177293090302,"ZNF555","zinc finger protein 555",TRUE
+"220709_at",0.758920166935337,0.256327560875245,1.16520521917669,-5.29918483527798,1.01026806534574,"ZNF556","zinc finger protein 556",TRUE
+"220444_at",0.384436276320932,0.0125021900491832,-2.71836007630868,-2.86668640983814,-1.69699845651305,"ZNF557","zinc finger protein 557",TRUE
+"239259_at",0.865345395265289,0.49490339321388,-0.693986093193208,-5.70778944004643,-0.251240195360742,"ZNF557","zinc finger protein 557",TRUE
+"227810_at",0.552420073963858,0.0498608216213813,2.07439780923053,-4.0364446493586,0.725634946452905,"ZNF558","zinc finger protein 558",TRUE
+"224518_s_at",0.759576632581869,0.257159545733953,1.16310817583095,-5.3014166051537,1.29054005062118,"ZNF559","zinc finger protein 559",TRUE
+"207417_s_at",0.974070871527453,0.874053791092974,-0.160355809160445,-5.92716690170905,-0.156279144709472,"ZNF559-ZNF177///ZNF177","ZNF559-ZNF177 readthrough///zinc finger protein 177",TRUE
+"1553276_at",0.873099882222,0.517536242943444,-0.657652354084546,-5.73119290446532,-0.463585160414305,"ZNF560","zinc finger protein 560",TRUE
+"1557114_a_at",0.997658807362705,0.988537557700293,-0.0145295325708642,-5.93958065868165,-0.00447161939757645,"ZNF561-AS1","ZNF561 antisense RNA 1 (head to head)",TRUE
+"230205_at",0.905934790589647,0.612401972250931,0.5139105895065,-5.81186037519985,0.2353844738014,"ZNF561///ZNF562","zinc finger protein 561///zinc finger protein 562",TRUE
+"235200_at",0.994943851647199,0.976285517656104,0.0300635683703974,-5.93924327384318,0.01139145986145,"ZNF561///ZNF562","zinc finger protein 561///zinc finger protein 562",TRUE
+"241089_at",0.314126572995991,0.00664614811329136,2.99445640666801,-2.31915178385436,2.25772421421279,"ZNF562","zinc finger protein 562",TRUE
+"219163_at",0.813065886130395,0.362921638292086,0.928957762694017,-5.52788610579026,0.277848603222189,"ZNF562","zinc finger protein 562",TRUE
+"1552770_s_at",0.843816788557882,0.439779901616727,0.786720096073726,-5.64264035725328,0.295300269154547,"ZNF563","zinc finger protein 563",TRUE
+"1553957_at",0.894305133027606,0.57071961045449,0.575549303117507,-5.77961568470107,0.232619416645493,"ZNF564","zinc finger protein 564",TRUE
+"228305_at",0.55937703282623,0.0532972848052735,-2.04139698672855,-4.09127180312773,-0.547031928934175,"ZNF565","zinc finger protein 565",TRUE
+"240239_at",0.632949074657601,0.10385318322083,-1.69621019769805,-4.62780369477285,-0.707884837512604,"ZNF566","zinc finger protein 566",TRUE
+"242429_at",0.496847720880538,0.0303926053465852,-2.31290529285402,-3.62398742628462,-0.82191590649906,"ZNF567","zinc finger protein 567",TRUE
+"235648_at",0.497725944448536,0.0305351555341838,-2.31069981760588,-3.62792441124057,-0.812119202722455,"ZNF567","zinc finger protein 567",TRUE
+"238315_s_at",0.616413638398853,0.0873305417078512,-1.78879319390572,-4.49087737775219,-0.607503384564872,"ZNF567","zinc finger protein 567",TRUE
+"238316_at",0.88587213211399,0.547848666860532,-0.610336578182679,-5.7598579433988,-0.285604930994625,"ZNF567","zinc finger protein 567",TRUE
+"1568900_a_at",0.812302873476553,0.358920967302342,-0.936879706727239,-5.5209773447727,-0.690011772177364,"ZNF568","zinc finger protein 568",TRUE
+"1564356_at",0.85334340854827,0.460259513724892,-0.751501336541587,-5.66829361620854,-0.547583768346794,"ZNF568","zinc finger protein 568",TRUE
+"1562282_at",0.913572663544659,0.637363192012327,0.477956188271641,-5.82902610894249,0.388604336272176,"ZNF568","zinc finger protein 568",TRUE
+"1561425_a_at",0.97339814920954,0.871242528173155,0.163968448596044,-5.92659694864827,0.0999849920755445,"ZNF568","zinc finger protein 568",TRUE
+"1560779_a_at",0.997654912087849,0.988406396434069,0.0146958020635284,-5.93957829192912,0.0126919374251591,"ZNF568","zinc finger protein 568",TRUE
+"1553696_s_at",0.936318756756998,0.71564541691396,-0.368979640164469,-5.87358847754624,-0.426714470604225,"ZNF569","zinc finger protein 569",TRUE
+"1569366_a_at",0.983783029912313,0.920959959449217,-0.100361466298376,-5.93477876492563,-0.095247925510864,"ZNF569","zinc finger protein 569",TRUE
+"1554628_at",0.740610299769501,0.230333535827,-1.23344974914396,-5.22464778900223,-0.415190139137367,"ZNF57","zinc finger protein 57",TRUE
+"231215_at",0.814642346108203,0.365505100912306,-0.923873126193152,-5.53229200575039,-0.978401631270708,"ZNF570","zinc finger protein 570",TRUE
+"1552562_at",0.954672574687803,0.793567164095451,0.264858080775809,-5.90557373864335,0.148806102552153,"ZNF570","zinc finger protein 570",TRUE
+"206648_at",0.668227498775206,0.134403252017027,-1.55378907941937,-4.82758702547639,-0.583982060251016,"ZNF571","zinc finger protein 571",TRUE
+"229328_at",0.993225426079816,0.968311288461867,-0.0401777111280753,-5.93889727042042,-0.0278297892553603,"ZNF571-AS1","ZNF571 antisense RNA 1",TRUE
+"1553229_at",0.945498722604777,0.754233633648512,0.316970103243602,-5.8908663531075,0.310940550066684,"ZNF572","zinc finger protein 572",TRUE
+"1556513_at",0.695925610637694,0.166050372829551,1.43217848107473,-4.98717183074327,0.833439989076953,"ZNF573","zinc finger protein 573",TRUE
+"217627_at",0.919354071504066,0.656209434402436,-0.451229679127621,-5.84099706312472,-0.252118502142555,"ZNF573","zinc finger protein 573",TRUE
+"218762_at",0.343267812511059,0.00860131510087152,-2.88275486902128,-2.54328290481397,-1.0961106145833,"ZNF574","zinc finger protein 574",TRUE
+"1557119_a_at",0.805746717966166,0.345431862345543,-0.964037261337051,-5.49688501891391,-0.347976758634417,"ZNF575","zinc finger protein 575",TRUE
+"219088_s_at",0.209327687796492,0.00243114918611381,-3.42039063780425,-1.43888991929344,-1.06814807772079,"ZNF576","zinc finger protein 576",TRUE
+"219089_s_at",0.676475496596199,0.143412950221688,-1.51697194262254,-4.87699956050119,-0.399834595148917,"ZNF576","zinc finger protein 576",TRUE
+"223581_at",0.736715608368239,0.222164890761741,-1.25609609779985,-5.1991039125031,-0.769637483110056,"ZNF577","zinc finger protein 577",TRUE
+"1556905_at",0.850493643619556,0.453182041650068,-0.763563210977187,-5.65963273559677,-0.521125475100376,"ZNF577","zinc finger protein 577",TRUE
+"1562244_at",0.754513748034606,0.247928310925545,1.18666472859949,-5.27614463638116,0.835148815256021,"ZNF578","zinc finger protein 578",TRUE
+"1562245_a_at",0.778295711796067,0.297870585671727,1.06607206764577,-5.40079152940932,1.16614148400718,"ZNF578","zinc finger protein 578",TRUE
+"229140_at",0.895089479199145,0.572611700300841,-0.572703818924333,-5.78118217243751,-0.218313613803133,"ZNF579","zinc finger protein 579",TRUE
+"220748_s_at",0.769258076576208,0.275615438193575,-1.11782644892817,-5.34874360837234,-0.620693776744393,"ZNF580","zinc finger protein 580",TRUE
+"223389_s_at",0.744706562599365,0.236194655114378,-1.21757417833726,-5.24231557586779,-0.404102473346459,"ZNF581","zinc finger protein 581",TRUE
+"241602_at",0.774230543658252,0.287819056523802,1.08908871447169,-5.37791568740598,0.32364677284016,"ZNF582","zinc finger protein 582",TRUE
+"231260_at",0.963863600435941,0.834784326866815,-0.211040879102057,-5.91801379286422,-0.235092227810132,"ZNF582-AS1","ZNF582 antisense RNA 1 (head to head)",TRUE
+"238708_at",0.981587171772385,0.912556356499495,-0.111075721865318,-5.93367597158335,-0.0604979426293735,"ZNF582-AS1","ZNF582 antisense RNA 1 (head to head)",TRUE
+"1563725_at",0.743323328391634,0.233406463098504,1.22508865891055,-5.23397742026233,0.995587079855504,"ZNF583","zinc finger protein 583",TRUE
+"1553221_at",0.950368936943548,0.774508693141268,0.290005590394455,-5.89880270888809,0.141391151668261,"ZNF583","zinc finger protein 583",TRUE
+"228148_at",0.959584210327095,0.817477938211921,0.233550917126857,-5.91315098646655,0.204513927888831,"ZNF584","zinc finger protein 584",TRUE
+"227674_at",0.39149295959037,0.0132397963994626,-2.6928793481999,-2.91605750098513,-1.87777160174736,"ZNF585A","zinc finger protein 585A",TRUE
+"229794_at",0.412444326023181,0.0164825142354042,-2.59472326491452,-3.10418231140081,-1.80778922294127,"ZNF585A","zinc finger protein 585A",TRUE
+"243790_at",0.6708432030569,0.136643616222316,-1.5444484993333,-4.8402119510526,-0.80169616306202,"ZNF585A","zinc finger protein 585A",TRUE
+"1554824_at",0.940227139261806,0.732121099353481,-0.34665506702824,-5.88132212598284,-0.142522306074562,"ZNF585A","zinc finger protein 585A",TRUE
+"235262_at",0.580213855105644,0.0628233383123075,-1.95893882604415,-4.22570523056845,-1.64378043750489,"ZNF585B","zinc finger protein 585B",TRUE
+"1557302_at",0.682125064335234,0.149643329470063,-1.492607275522,-4.90917942647178,-0.736442417225308,"ZNF585B","zinc finger protein 585B",TRUE
+"219711_at",0.70239414369209,0.173803207499045,-1.40528580889859,-5.02103377912051,-0.499525179652437,"ZNF586","zinc finger protein 586",TRUE
+"1554665_at",0.849935057946582,0.45244387963438,0.764827743268346,-5.65871720251311,0.50042805066941,"ZNF586","zinc finger protein 586",TRUE
+"231820_x_at",0.923376218980614,0.671084194125509,-0.430369428808099,-5.849871137501,-0.200177552398323,"ZNF587","zinc finger protein 587",TRUE
+"219981_x_at",0.929088231432081,0.687889450444108,-0.407032612736508,-5.85930961516656,-0.166614063300447,"ZNF587","zinc finger protein 587",TRUE
+"221963_x_at",0.811844013927892,0.355994506691593,-0.942712185870154,-5.51585638283013,-0.388767026952911,"ZNF587B","zinc finger protein 587B",TRUE
+"1569108_a_at",0.715994230654393,0.191687579723213,1.34671323527213,-5.09294352080851,0.866176227380367,"ZNF589","zinc finger protein 589",TRUE
+"210061_at",0.728385463227073,0.208969213578731,1.29406613320373,-5.15538442133652,0.370512340630573,"ZNF589","zinc finger protein 589",TRUE
+"210062_s_at",0.736689183725895,0.222131831420304,1.25618903208276,-5.19899826545217,0.379348669538658,"ZNF589","zinc finger protein 589",TRUE
+"219968_at",0.813970831648786,0.364950726420454,-0.924962189216164,-5.53135019208447,-0.425029893850343,"ZNF589","zinc finger protein 589",TRUE
+"213389_at",0.793016712530949,0.324861765504068,-1.00688180308951,-5.45760064741925,-0.398860421506178,"ZNF592","zinc finger protein 592",TRUE
+"204473_s_at",0.837345289209351,0.420242427725736,-0.821269030153705,-5.61640129398035,-0.25397349653038,"ZNF592","zinc finger protein 592",TRUE
+"227507_at",0.854400503339099,0.465568242965936,-0.742526537473744,-5.67465312204868,-0.225426032610052,"ZNF592","zinc finger protein 592",TRUE
+"204175_at",0.769487370840268,0.27698730581632,-1.1145503577721,-5.3521032601617,-0.289271779762625,"ZNF593","zinc finger protein 593",TRUE
+"235690_at",0.82849258297242,0.398572531512842,0.860791120360862,-5.58509220028492,0.397736965718815,"ZNF594","zinc finger protein 594",TRUE
+"243980_at",0.998870448604467,0.995498001089911,0.00570645450847438,-5.93966762022136,0.00411603105406844,"ZNF594","zinc finger protein 594",TRUE
+"227952_at",0.773156930607264,0.28401648720955,1.09794690985144,-5.36899560869371,1.72635119607271,"ZNF595","zinc finger protein 595",TRUE
+"1570038_at",0.819807973515613,0.377747144276055,0.900098518607818,-5.55259704719833,0.84054724824295,"ZNF595","zinc finger protein 595",TRUE
+"232641_at",0.931370027472813,0.695934868824309,0.395941917614777,-5.86361371641628,0.25095129463015,"ZNF596","zinc finger protein 596",TRUE
+"236117_at",0.043795211728206,5.01628511678275e-05,-5.0121303818683,1.97644795235189,-3.37115274477189,"ZNF597","zinc finger protein 597",TRUE
+"230542_at",0.183534093706442,0.0017518631280003,-3.556715727485,-1.15064288655473,-1.95498576720572,"ZNF597","zinc finger protein 597",TRUE
+"232367_x_at",0.636147339487472,0.10744792515207,-1.67774947290616,-4.65445505070985,-1.2399967544456,"ZNF598","zinc finger protein 598",TRUE
+"225104_at",0.720018659171833,0.195985105977921,-1.33328527572845,-5.10906862426752,-0.503361265649319,"ZNF598","zinc finger protein 598",TRUE
+"1558390_at",0.603702127972549,0.0777183033531852,1.84985166327957,-4.3976797239081,0.83028419789574,"ZNF599","zinc finger protein 599",TRUE
+"1558391_s_at",0.760237493549547,0.258276125172622,-1.16030169633951,-5.3043978741284,-1.06320244168653,"ZNF599","zinc finger protein 599",TRUE
+"228093_at",0.924071812782474,0.673325961580996,-0.427242579654871,-5.85116577730297,-0.285817887580585,"ZNF599","zinc finger protein 599",TRUE
+"243747_at",0.931582451098271,0.69773579125702,0.393466283972727,-5.86455847935665,0.228566049542499,"ZNF599","zinc finger protein 599",TRUE
+"242463_x_at",0.927934056345262,0.683777507015898,-0.412721001929805,-5.85705665479608,-0.147633324498234,"ZNF600","zinc finger protein 600",TRUE
+"1559849_at",0.907293104315614,0.616444887775334,0.508041611431146,-5.8147453549833,0.505905864083878,"ZNF605","zinc finger protein 605",TRUE
+"227822_at",0.955730092376044,0.797192032315819,0.260095282291464,-5.90678748528134,0.156951933418927,"ZNF605","zinc finger protein 605",TRUE
+"229707_at",0.812302873476553,0.358922219444119,0.936877218048089,-5.52097952362405,0.505675173406087,"ZNF606","zinc finger protein 606",TRUE
+"219635_at",0.947969282616012,0.76362668719801,0.304449363207446,-5.89463844773734,0.152885967822854,"ZNF606","zinc finger protein 606",TRUE
+"223680_at",0.714782078270721,0.190136597546778,-1.35161748701518,-5.08702044612801,-0.995614723147987,"ZNF607","zinc finger protein 607",TRUE
+"232303_at",0.91339551560427,0.636910200031475,0.478602880226124,-5.82872810004178,0.285993302604975,"ZNF608","zinc finger protein 608",TRUE
+"229817_at",0.965592860493733,0.839125362112468,0.205412506310929,-5.91915306525565,0.127092211386643,"ZNF608","zinc finger protein 608",TRUE
+"212620_at",0.0292355916753786,2.88746584448184e-05,-5.24014268031814,2.4584292007679,-2.09453037204923,"ZNF609","zinc finger protein 609",TRUE
+"212618_at",0.0796131074879114,0.000269381342208754,-4.32449313608948,0.50021111654342,-2.56101571017794,"ZNF609","zinc finger protein 609",TRUE
+"212617_at",0.455844917627971,0.0222236326706914,-2.45862207732539,-3.35921335373967,-0.734492937599405,"ZNF609","zinc finger protein 609",TRUE
+"235953_at",0.972473496102009,0.867268275720372,-0.16907942427748,-5.92576897698501,-0.104373993037997,"ZNF610","zinc finger protein 610",TRUE
+"208137_x_at",0.96635324070119,0.843356401157714,0.199933275117485,-5.92023268618955,0.0649301898632029,"ZNF611","zinc finger protein 611",TRUE
+"1559059_s_at",0.975913043793143,0.884845675719387,0.146507424139994,-5.92923435500147,0.0514029510310339,"ZNF611","zinc finger protein 611",TRUE
+"219851_at",0.657015752622694,0.125668160508354,-1.59148544580174,-4.77602864282018,-1.3443637741205,"ZNF613","zinc finger protein 613",TRUE
+"210599_at",0.844169896707408,0.440735952799272,-0.785054043277364,-5.6438788749065,-0.542891143267219,"ZNF614","zinc finger protein 614",TRUE
+"227045_at",0.961904506047105,0.827017961047322,-0.221127919748834,-5.91589530745227,-0.109559736780472,"ZNF614","zinc finger protein 614",TRUE
+"220721_at",0.991359510893995,0.959429685252982,-0.0514478319299011,-5.9383943656068,-0.0218831696355917,"ZNF614","zinc finger protein 614",TRUE
+"241827_at",0.85334340854827,0.460344794104429,-0.751356677014197,-5.66839669517665,-0.443475706832002,"ZNF615","zinc finger protein 615",TRUE
+"232137_at",0.753523115318527,0.246787449833321,-1.18962122401605,-5.27294160869646,-0.554726325146168,"ZNF616","zinc finger protein 616",TRUE
+"239007_at",0.781196073006007,0.302905473209462,-1.05475120009784,-5.41188262174933,-0.511472355373934,"ZNF616","zinc finger protein 616",TRUE
+"238444_at",0.772430642757484,0.282852678595985,-1.10067516333711,-5.36623534759685,-1.25836064504419,"ZNF618","zinc finger protein 618",TRUE
+"226592_at",0.917806614232276,0.651038665769373,-0.458528544562317,-5.83779482248392,-0.427203492247106,"ZNF618","zinc finger protein 618",TRUE
+"226590_at",0.991754150288374,0.961756555224731,0.048494600550666,-5.93853810649744,0.0470221014188654,"ZNF618","zinc finger protein 618",TRUE
+"1552836_at",0.880424050551021,0.535838878941669,0.628909655901348,-5.74885134696802,0.192425607365396,"ZNF619","zinc finger protein 619",TRUE
+"1558743_at",0.649509378726358,0.120061486240066,-1.61684629325174,-4.74080026803881,-1.24072682455722,"ZNF620","zinc finger protein 620",TRUE
+"1558620_at",0.68747436517451,0.156278048859952,-1.46755428940059,-4.94183097891855,-0.476720407025489,"ZNF621","zinc finger protein 621",TRUE
+"241499_at",0.916700610296353,0.647449671096552,0.463609522556239,-5.83553591528271,0.192546146836768,"ZNF621","zinc finger protein 621",TRUE
+"230164_at",0.936992192746977,0.719140827118156,-0.364227751416489,-5.87527453715641,-0.127871141828123,"ZNF621","zinc finger protein 621",TRUE
+"225152_at",0.488346123638981,0.0290266650998185,2.33453391869059,-3.58526360946153,0.852179590871893,"ZNF622","zinc finger protein 622",TRUE
+"206188_at",0.77204612088057,0.282292221316195,-1.10199191374806,-5.3649009704776,-0.651074549362995,"ZNF623","zinc finger protein 623",TRUE
+"232272_at",0.804537788156734,0.343460750130157,0.968065645651379,-5.49325768625867,0.417733047767202,"ZNF624","zinc finger protein 624",TRUE
+"1552769_at",0.748360379918568,0.240885127136477,1.20508266600281,-5.25607794964816,0.320643679784916,"ZNF625","zinc finger protein 625",TRUE
+"213916_at",0.841967750949524,0.434794193652548,0.795444654725946,-5.63611429789428,0.593908268991095,"ZNF625-ZNF20///ZNF20","ZNF625-ZNF20 readthrough (NMD candidate)///zinc finger protein 20",TRUE
+"244406_at",0.84571977676742,0.443574903460401,-0.780119776938166,-5.64753241567447,-0.884020416338196,"ZNF625-ZNF20///ZNF625","ZNF625-ZNF20 readthrough (NMD candidate)///zinc finger protein 625",TRUE
+"1552643_at",0.915123892058533,0.642268845175347,-0.47096602688644,-5.83222215463083,-0.36467230628069,"ZNF626","zinc finger protein 626",TRUE
+"1559616_x_at",0.931121627074226,0.695038887336438,0.397174514172943,-5.86314115065362,0.371639261750105,"ZNF626","zinc finger protein 626",TRUE
+"235687_at",0.968770511919929,0.852748393729683,-0.187792650511041,-5.92252125660383,-0.128287956102878,"ZNF626","zinc finger protein 626",TRUE
+"1563204_at",0.67368843181164,0.140253267587462,1.52966123958086,-4.86007541368109,0.910123639204443,"ZNF627","zinc finger protein 627",TRUE
+"224492_s_at",0.926312120590894,0.679909653949372,-0.418084389254334,-5.85490424668905,-0.207929977720903,"ZNF627","zinc finger protein 627",TRUE
+"1563344_at",0.730048787941067,0.21242982905111,1.28393356092426,-5.16715983862092,0.541308950377067,"ZNF628","zinc finger protein 628",TRUE
+"236269_at",0.983567332578112,0.919834437481375,-0.10179573555256,-5.93463761152947,-0.026383790943866,"ZNF628","zinc finger protein 628",TRUE
+"213196_at",0.55937703282623,0.0535970347148821,-2.03860936751712,-4.09587670144203,-0.593285838949493,"ZNF629","zinc finger protein 629",TRUE
+"233082_at",0.928295253101366,0.685144665425524,-0.410828171195465,-5.85780975014207,-0.342117780317619,"ZNF630","zinc finger protein 630",TRUE
+"1554248_at",0.804351886842858,0.343091598958726,0.968821836705702,-5.4925752390573,0.330541941221625,"ZNF638","zinc finger protein 638",TRUE
+"211257_x_at",0.92051722798026,0.661952099248659,-0.443152600305822,-5.84448199257457,-0.110171557911038,"ZNF638","zinc finger protein 638",TRUE
+"239243_at",0.752913428584105,0.246179432240107,1.19120105834646,-5.27122719044577,0.615713381272887,"ZNF638-IT1///ZNF638","ZNF638 intronic transcript 1///zinc finger protein 638",TRUE
+"213775_x_at",0.896229101808264,0.579810051075762,0.561921574277593,-5.78704969686834,0.156767345489923,"ZNF638-IT1///ZNF638","ZNF638 intronic transcript 1///zinc finger protein 638",TRUE
+"1554249_a_at",0.937271400689562,0.721899595596433,0.360483330808746,-5.8765879276207,0.100438946407076,"ZNF638-IT1///ZNF638","ZNF638 intronic transcript 1///zinc finger protein 638",TRUE
+"222623_s_at",0.77204612088057,0.282304233843392,1.10196367140251,-5.36492960576921,0.328038957582617,"ZNF639","zinc finger protein 639",TRUE
+"218413_s_at",0.842928408549809,0.436862752740645,0.791817420807012,-5.63883573316083,0.525126979405114,"ZNF639","zinc finger protein 639",TRUE
+"222624_s_at",0.893600768892136,0.568767135790235,0.578490638878317,-5.77798852615049,0.177825925944864,"ZNF639","zinc finger protein 639",TRUE
+"1554958_at",0.76029267756668,0.258844121390145,-1.15887750866653,-5.30590834466104,-0.775428754029945,"ZNF641","zinc finger protein 641",TRUE
+"226509_at",0.893395477698951,0.568084680773059,-0.579519949050444,-5.77741721080155,-0.239996607616225,"ZNF641","zinc finger protein 641",TRUE
+"235179_at",0.91876780831279,0.654392317578558,-0.453791797551428,-5.83987871880132,-0.23425514044268,"ZNF641","zinc finger protein 641",TRUE
+"229897_at",0.984161165881616,0.92246541944514,0.0984433729766034,-5.93496440645308,0.0660315521686234,"ZNF641","zinc finger protein 641",TRUE
+"229684_s_at",0.933609099853387,0.706330752747396,-0.381685328363226,-5.86897435976975,-0.103065294856215,"ZNF644","zinc finger protein 644",TRUE
+"222580_at",0.975736035786165,0.884131955828408,0.147422349591881,-5.92910350834447,0.041510114021035,"ZNF644","zinc finger protein 644",TRUE
+"1553725_s_at",0.999509719152342,0.998905537603066,-0.00138726522864078,-5.93968254339381,-0.000492663490669898,"ZNF644","zinc finger protein 644",TRUE
+"1552967_at",0.850450293594674,0.453064854514591,0.763763879127668,-5.65948754557448,0.343344522346668,"ZNF645","zinc finger protein 645",TRUE
+"204876_at",0.640337040581689,0.111025651831635,-1.65988800360852,-4.68003074678661,-0.776195238931529,"ZNF646","zinc finger protein 646",TRUE
+"223616_at",0.906476756086155,0.613638692944907,0.512113347245416,-5.8127472673674,0.588719809684272,"ZNF649","zinc finger protein 649",TRUE
+"237055_at",0.552420073963858,0.0496670793772155,2.0763183407784,-4.03323627788226,1.17390319292654,"ZNF649-AS1","ZNF649 antisense RNA 1",TRUE
+"205594_at",0.40221114169538,0.0145914708702127,-2.64948020753559,-2.99964726826941,-1.47018946849754,"ZNF652","zinc finger protein 652",TRUE
+"243495_s_at",0.415590231477955,0.0168755816550396,-2.58408647100469,-3.12436461314577,-2.19544469047703,"ZNF652","zinc finger protein 652",TRUE
+"225266_at",0.536440072751377,0.0433174745532204,-2.14331372132996,-3.92012795762364,-1.21714040120519,"ZNF652","zinc finger protein 652",TRUE
+"235577_at",0.637485146909712,0.108626414655233,-1.67181118269941,-4.6629811080554,-1.04061948694849,"ZNF652","zinc finger protein 652",TRUE
+"228864_at",0.688170188042602,0.157545976108445,1.46286517894742,-4.94789263985782,0.528973922027679,"ZNF653","zinc finger protein 653",TRUE
+"244085_at",0.95726903979743,0.806557162438925,0.247818332520283,-5.90981521163511,0.108584872532083,"ZNF653","zinc finger protein 653",TRUE
+"1556744_a_at",0.774421352016308,0.290760338622602,1.08229462471883,-5.38471359759589,0.300016544255775,"ZNF654","zinc finger protein 654",TRUE
+"241348_at",0.778028733502341,0.297347481632424,-1.06725606345579,-5.39962543723196,-0.451634304973503,"ZNF654","zinc finger protein 654",TRUE
+"242017_at",0.818268955967428,0.371327557652243,0.912500864333729,-5.54206557272172,0.404765454023199,"ZNF654","zinc finger protein 654",TRUE
+"222851_at",0.895758940460776,0.576544556422367,-0.566804468031923,-5.78440589775753,-0.236926836140416,"ZNF654","zinc finger protein 654",TRUE
+"1556743_at",0.908801761853008,0.621088802325987,0.501322403453211,-5.81800858672592,0.55806717811769,"ZNF654","zinc finger protein 654",TRUE
+"219239_s_at",0.95018792835023,0.773672158745359,0.291113657237453,-5.89849035105992,0.113899235212444,"ZNF654","zinc finger protein 654",TRUE
+"1554726_at",0.694449308437732,0.163708406702404,1.44050021982501,-4.97658703095093,2.49511503162478,"ZNF655","zinc finger protein 655",TRUE
+"225945_at",0.754682106570676,0.248271010158913,1.18577862549507,-5.27710327527594,1.72104834515115,"ZNF655","zinc finger protein 655",TRUE
+"223302_s_at",0.756207119282867,0.251103573322237,1.17848935707315,-5.28496552153238,1.72050649520901,"ZNF655","zinc finger protein 655",TRUE
+"231950_at",0.652992478303356,0.122333826342227,-1.60645099754174,-4.75529248394452,-1.11340794585353,"ZNF658","zinc finger protein 658",TRUE
+"1561361_at",0.999503346640971,0.998572400096151,-0.00180952783599049,-5.93968188591411,-0.00161902245101686,"ZNF660","zinc finger protein 660",TRUE
+"228538_at",0.55937703282623,0.0535971018884662,2.03860874437548,-4.09587773035303,1.68236092012328,"ZNF662","zinc finger protein 662",TRUE
+"1553911_at",0.90323329640112,0.60322933366414,0.527294744365345,-5.80516043768573,0.167962404411001,"ZNF663P","zinc finger protein 663, pseudogene",TRUE
+"224593_at",0.841978122235322,0.43502587974441,-0.795037863034407,-5.63642008747475,-0.302972882783113,"ZNF664","zinc finger protein 664",TRUE
+"1569935_at",0.866807918403275,0.498263544061705,0.688533420640591,-5.71137835680459,0.233891225210813,"ZNF664","zinc finger protein 664",TRUE
+"1569936_a_at",0.896229101808264,0.57951181779039,-0.56236694830816,-5.78680947250873,-0.361742478127619,"ZNF664","zinc finger protein 664",TRUE
+"1558816_at",0.965815966108792,0.840043498277158,0.204222971503884,-5.91938992028852,0.0846897438264431,"ZNF664","zinc finger protein 664",TRUE
+"227320_at",0.90998880119877,0.625395017237353,0.495112645968068,-5.82098669142669,0.525616905342008,"ZNF664-FAM101A///FAM101A","filamin-interacting protein FAM101A///family with sequence similarity 101 member A",TRUE
+"220760_x_at",0.993863709454116,0.970996209746877,0.0367718555449695,-5.93902491036788,0.0152726053446752,"ZNF665","zinc finger protein 665",TRUE
+"207120_at",0.824027323790285,0.391409350530583,0.874157374090784,-5.57419349924514,1.2321021022639,"ZNF667","zinc finger protein 667",TRUE
+"236635_at",0.947062793209778,0.75947261167411,0.309980411755813,-5.89299069088234,0.281618765935683,"ZNF667","zinc finger protein 667",TRUE
+"244741_s_at",0.837368340567858,0.420760392765147,0.820340321015445,-5.617120461019,1.24227378339228,"ZNF667-AS1","ZNF667 antisense RNA 1 (head to head)",TRUE
+"219047_s_at",0.500677386446044,0.0320063674923074,-2.28847335897764,-3.66747870476603,-2.00229684079015,"ZNF668","zinc finger protein 668",TRUE
+"222813_at",0.825019652722105,0.392387947862563,-0.872322063354947,-5.57569923525824,-0.486454221021964,"ZNF668","zinc finger protein 668",TRUE
+"220215_at",0.583669389655723,0.0646706751263717,-1.94424518543,-4.24926660020633,-0.997545851906873,"ZNF669","zinc finger protein 669",TRUE
+"223898_at",0.979794616772313,0.903696954350021,0.122385569531354,-5.93239077050871,0.0498193304909353,"ZNF670","zinc finger protein 670",TRUE
+"208273_at",0.88734438113787,0.551812707427896,0.604253715312494,-5.76339353895793,0.339847414308427,"ZNF670-ZNF695///ZNF670///ZNF695","ZNF670-ZNF695 readthrough (NMD candidate)///zinc finger protein 670///zinc finger protein 695",TRUE
+"219849_at",0.906476756086155,0.613986656506455,0.511607983509326,-5.81299610552308,0.300644037905354,"ZNF671","zinc finger protein 671",TRUE
+"222509_s_at",0.340661724554519,0.00848616861167362,-2.88862391129432,-2.53159014144336,-1.07913341132336,"ZNF672","zinc finger protein 672",TRUE
+"218068_s_at",0.584828007864693,0.0650592197628314,-1.9412019154773,-4.25413131988669,-0.733972963936132,"ZNF672","zinc finger protein 672",TRUE
+"227011_at",0.994379916442633,0.974294127144385,0.0325890125383812,-5.93916621164045,0.0236097964441306,"ZNF672","zinc finger protein 672",TRUE
+"215309_at",0.93990349909644,0.729832703322165,0.349744869461206,-5.88028018478351,0.344426848758618,"ZNF674","zinc finger protein 674",TRUE
+"241972_at",0.841247691968787,0.431382737244581,-0.801450019801334,-5.63158289092813,-0.520091123525399,"ZNF674-AS1","ZNF674 antisense RNA 1 (head to head)",TRUE
+"1554465_s_at",0.96882227301574,0.852900273746075,-0.187596563874099,-5.92255704795997,-0.0785551958878967,"ZNF674///KRBOX4","zinc finger protein 674///KRAB box domain containing 4",TRUE
+"217547_x_at",0.972438691973544,0.867199609607285,0.169167770528836,-5.92575444217973,0.0830689652481258,"ZNF675","zinc finger protein 675",TRUE
+"238254_at",0.652139736047968,0.121266760608549,1.61131223141043,-4.74852438545798,0.995566307466205,"ZNF677","zinc finger protein 677",TRUE
+"228974_at",0.699547441386804,0.171064458917999,1.41467405153732,-5.00927247751834,2.4377970013377,"ZNF677","zinc finger protein 677",TRUE
+"1560562_a_at",0.772532966757283,0.283008793060842,1.10030872123342,-5.36660644284851,2.00610817409678,"ZNF677","zinc finger protein 677",TRUE
+"1569039_s_at",0.918530321945653,0.65403390880048,0.454297514590516,-5.8396572437663,0.423874253124458,"ZNF677","zinc finger protein 677",TRUE
+"232028_at",0.497871139123625,0.0309015660089875,-2.30507391653315,-3.63795731872336,-0.852370235927609,"ZNF678","zinc finger protein 678",TRUE
+"242923_at",0.603702127972549,0.0779893826436017,-1.84804212299686,-4.4004739639878,-0.646692929514487,"ZNF678","zinc finger protein 678",TRUE
+"1554922_at",0.723854608607992,0.200772842058348,-1.31859444188003,-5.12655451722872,-0.724457669714246,"ZNF678","zinc finger protein 678",TRUE
+"230534_at",0.792305111661886,0.323338136927083,-1.01012909389611,-5.4545599685677,-0.614720338714662,"ZNF678","zinc finger protein 678",TRUE
+"229533_x_at",0.232037111848437,0.00298257240383628,-3.33483084334261,-1.61843263119736,-1.44435139970518,"ZNF680","zinc finger protein 680",TRUE
+"238962_at",0.382928576778789,0.012150892522166,-2.73099940020339,-2.8421179616147,-2.2149396721569,"ZNF681","zinc finger protein 681",TRUE
+"236672_at",0.901507587832957,0.598315183087614,0.534505329495308,-5.80148140795351,0.177494914468419,"ZNF681","zinc finger protein 681",TRUE
+"216468_s_at",0.074257558926502,0.000240394840969197,-4.37092737845341,0.600519402015828,-3.63462451985626,"ZNF682","zinc finger protein 682",TRUE
+"242915_at",0.0784999806891434,0.000257200696188267,-4.34336583071435,0.540984198331008,-2.77345169925622,"ZNF682","zinc finger protein 682",TRUE
+"230756_at",0.676468346171966,0.143372934530238,1.51713120516481,-4.87678784288667,0.926000578781788,"ZNF683","zinc finger protein 683",TRUE
+"244398_x_at",0.640067422642767,0.110566148853802,-1.66215458119413,-4.6767967858404,-0.634683803190785,"ZNF684","zinc finger protein 684",TRUE
+"232563_at",0.790361168948463,0.320047804352405,-1.01717830053676,-5.44792877187718,-0.492732886728305,"ZNF684","zinc finger protein 684",TRUE
+"234924_s_at",0.91671872326659,0.648045563954707,-0.462765056102945,-5.8359130388474,-0.203601673478584,"ZNF687","zinc finger protein 687",TRUE
+"235951_s_at",0.514138533321383,0.0346036098524704,-2.25142384939293,-3.7329114524091,-1.60506010966647,"ZNF688","zinc finger protein 688",TRUE
+"213527_s_at",0.552281323843226,0.0494957199237642,-2.07802259763391,-4.03038759587848,-0.780898446097718,"ZNF688","zinc finger protein 688",TRUE
+"235950_at",0.683300986833698,0.152375860144844,-1.48218185416038,-4.92282102433552,-0.774703322291031,"ZNF688","zinc finger protein 688",TRUE
+"213529_at",0.894739995320804,0.572077197191123,-0.573507164883974,-5.78074067865967,-0.236486637131318,"ZNF688","zinc finger protein 688",TRUE
+"228631_s_at",0.982683819649865,0.915877495779018,-0.106839882413201,-5.93412530067492,-0.0792488583780919,"ZNF688","zinc finger protein 688",TRUE
+"227294_at",0.365243500989124,0.0107084651501704,-2.78681029763238,-2.733025320917,-1.06436661565392,"ZNF689","zinc finger protein 689",TRUE
+"227445_at",0.589107392040311,0.0677190664649905,-1.92078825032534,-4.28662720702598,-0.8543553158483,"ZNF689","zinc finger protein 689",TRUE
+"232780_s_at",0.789378278298554,0.315903337487677,-1.02612987565901,-5.43944793473054,-0.404229923256406,"ZNF691","zinc finger protein 691",TRUE
+"220661_s_at",0.568522113294759,0.0579388242392025,-1.99971523911682,-4.15969058482443,-0.876257460633116,"ZNF692","zinc finger protein 692",TRUE
+"232162_at",0.724067243569133,0.20121693001612,1.31724570202641,-5.12815167952976,0.424402882946368,"ZNF696","zinc finger protein 696",TRUE
+"220967_s_at",0.834747247306943,0.41332011850194,0.833750467496042,-5.60666211554785,0.363037506179065,"ZNF696","zinc finger protein 696",TRUE
+"227080_at",0.713633547141264,0.188556660007783,1.35664578019355,-5.08092886743523,0.596238215753628,"ZNF697","zinc finger protein 697",TRUE
+"1553702_at",0.979588787486838,0.902724593879764,-0.123627846771535,-5.93224202428604,-0.0615264972489173,"ZNF697","zinc finger protein 697",TRUE
+"234920_at",0.78187900363728,0.303481043941823,-1.05346558913429,-5.4131354223347,-0.784383896306225,"ZNF7","zinc finger protein 7",TRUE
+"1559980_at",0.789503009592599,0.316408425417304,1.02503455664782,-5.44048925825753,0.557645149931729,"ZNF7","zinc finger protein 7",TRUE
+"234914_at",0.908709061737317,0.620579679989534,0.502057898611682,-5.81765345457761,0.326338211008676,"ZNF7","zinc finger protein 7",TRUE
+"205089_at",0.967701855457407,0.848010037466218,-0.193913993017701,-5.92138520102669,-0.0913056360430815,"ZNF7","zinc finger protein 7",TRUE
+"243816_at",0.405811824873907,0.015178512699902,-2.63180075813619,-3.03351408595861,-0.949130088106179,"ZNF70","zinc finger protein 70",TRUE
+"1554578_at",0.866077812635028,0.496800900524892,0.69090433669201,-5.7098211554822,0.250659737254683,"ZNF70","zinc finger protein 70",TRUE
+"223590_at",0.994701128358967,0.975587682995712,-0.0309485255542454,-5.93921697697913,-0.0122843717553405,"ZNF700","zinc finger protein 700",TRUE
+"220242_x_at",0.912244494826693,0.632238368968853,-0.485284549322398,-5.82562598355455,-0.236578142627366,"ZNF701","zinc finger protein 701",TRUE
+"236589_at",0.921797789017863,0.666681567310949,0.436523026966292,-5.84729622612528,0.200724039823314,"ZNF701","zinc finger protein 701",TRUE
+"206557_at",0.911393258378799,0.629523345120396,-0.489177885210811,-5.8237990290354,-0.542112494859166,"ZNF702P","zinc finger protein 702, pseudogene",TRUE
+"222760_at",0.25025917061226,0.00349649357712018,-3.26797768691692,-1.757878533346,-4.18874048609189,"ZNF703","zinc finger protein 703",TRUE
+"230586_s_at",0.888686718625571,0.555006236833203,-0.599369885971927,-5.76620746482646,-0.41416410092839,"ZNF703","zinc finger protein 703",TRUE
+"223366_at",0.840575764979183,0.429735231507967,-0.804360743417065,-5.62937505209173,-0.73016878305892,"ZNF704","zinc finger protein 704",TRUE
+"241963_at",0.932609903725425,0.702284681411672,-0.38722425040394,-5.86691467228138,-0.245783601034998,"ZNF704","zinc finger protein 704",TRUE
+"1558941_at",0.939290937475152,0.728234340370166,0.351905044783635,-5.87954630475789,0.295798285468118,"ZNF704","zinc finger protein 704",TRUE
+"235732_at",0.942502815705589,0.742521559829951,-0.332655058222248,-5.88592863186014,-0.343093535203038,"ZNF704","zinc finger protein 704",TRUE
+"235079_at",0.962741248200658,0.830368693678155,-0.216773136007995,-5.91682197779954,-0.275362796963806,"ZNF704","zinc finger protein 704",TRUE
+"235905_at",0.98529096111871,0.926992776960201,0.0926773557720386,-5.93550091629544,0.0573981912794537,"ZNF704","zinc finger protein 704",TRUE
+"237711_at",0.942502815705589,0.742109891607058,-0.333207897377406,-5.8857502896671,-0.209693769815537,"ZNF705G","zinc finger protein 705G",TRUE
+"218059_at",0.951965886159476,0.780411796057431,0.282196827543339,-5.9009704450143,0.105933363562471,"ZNF706","zinc finger protein 706",TRUE
+"227132_at",0.954456115752166,0.791362768695195,-0.267757543607558,-5.904824130402,-0.138191353183405,"ZNF706","zinc finger protein 706",TRUE
+"239482_x_at",0.42796179417767,0.0185671351152297,-2.5408098438449,-3.20604908400373,-0.927530436312705,"ZNF708","zinc finger protein 708",TRUE
+"1562267_s_at",0.677013732819214,0.14453707028464,1.51251275265913,-4.88292023590687,0.614597961438117,"ZNF709","zinc finger protein 709",TRUE
+"1570364_at",0.897949253801113,0.586638420373528,0.551755380145538,-5.79248287739505,0.43373478813229,"ZNF709","zinc finger protein 709",TRUE
+"1553247_a_at",0.906878681039516,0.615178447394048,0.509878111169414,-5.81384607104106,0.279215369824035,"ZNF709","zinc finger protein 709",TRUE
+"1570366_x_at",0.912252515563073,0.632539036877605,0.484853861037759,-5.8258272081959,0.263784128222675,"ZNF709","zinc finger protein 709",TRUE
+"242028_at",0.989524702314661,0.948581672917335,0.0652226064375486,-5.93761173223474,0.0285019894887046,"ZNF709","zinc finger protein 709",TRUE
+"233754_x_at",0.522667179791589,0.0385071938423412,-2.20025338185412,-3.82222776532031,-1.13032968590107,"ZNF71","zinc finger protein 71",TRUE
+"234575_at",0.896328858604647,0.580404698857593,0.561033884932755,-5.78752794510982,0.229233933749289,"ZNF71","zinc finger protein 71",TRUE
+"234570_at",0.913160385122315,0.635632979429157,0.480427358627555,-5.82788521865574,0.300076311003006,"ZNF71","zinc finger protein 71",TRUE
+"226514_at",0.976422537443518,0.888059573643788,-0.14238906700261,-5.92981327008833,-0.128689197954065,"ZNF71","zinc finger protein 71",TRUE
+"213542_at",0.722080068577879,0.198263413969699,-1.32625987857655,-5.11745102156835,-0.881567280611254,"ZNF710","zinc finger protein 710",TRUE
+"235090_at",0.768852835478002,0.272000993782998,1.12651527956976,-5.33979089640751,0.581297791678275,"ZNF710","zinc finger protein 710",TRUE
+"39891_at",0.863408882018863,0.487826514313412,-0.705539771794311,-5.7000956421087,-0.291723765744614,"ZNF710","zinc finger protein 710",TRUE
+"239335_at",0.903488560782255,0.604622641983757,-0.525255483148699,-5.80619209893502,-0.170867465642045,"ZNF710","zinc finger protein 710",TRUE
+"239700_at",0.980663666733946,0.90947489862429,0.115007728422472,-5.9332432577619,0.0915339842803204,"ZNF710","zinc finger protein 710",TRUE
+"228988_at",0.680600405327108,0.148356573034997,-1.49757045241338,-4.90265813786522,-2.00694693002517,"ZNF711","zinc finger protein 711",TRUE
+"207781_s_at",0.817755229158552,0.370239812442487,-0.914616367616217,-5.54025591182517,-1.29251414446774,"ZNF711","zinc finger protein 711",TRUE
+"1560201_at",0.949503174041699,0.771831173486556,0.293553525195811,-5.89779840120271,0.267674116861389,"ZNF713","zinc finger protein 713",TRUE
+"221370_at",0.849130638531986,0.449872285438611,-0.76924286022713,-5.65550939488678,-0.454669023113096,"ZNF717","zinc finger protein 717",TRUE
+"229986_at",0.931528703027792,0.69736223571166,-0.393979584991302,-5.86436307070354,-0.260164302551853,"ZNF717","zinc finger protein 717",TRUE
+"1569479_at",0.523369751179323,0.0387366467528489,-2.19739463548996,-3.82718076362154,-1.27073994550144,"ZNF718","zinc finger protein 718",TRUE
+"1553269_at",0.80110325033185,0.337818683852787,-0.979684459262912,-5.48271830368943,-0.574685684288611,"ZNF718","zinc finger protein 718",TRUE
+"1559746_a_at",0.910159094731364,0.626015479218355,-0.494219541719985,-5.82141202911039,-0.277857071044833,"ZNF718///ZNF595","zinc finger protein 718///zinc finger protein 595",TRUE
+"208542_x_at",0.942387644677023,0.741207057778619,-0.334420705820073,-5.88535801945448,-0.308349443670547,"ZNF718///ZNF595///ZNF208","zinc finger protein 718///zinc finger protein 595///zinc finger protein 208",TRUE
+"242091_at",0.809109571194383,0.352267273860362,0.950187604439715,-5.50925029048678,0.29899468594234,"ZNF720","zinc finger protein 720",TRUE
+"238510_at",0.847797601020174,0.447374745797441,-0.773545494615797,-5.65236653789126,-0.353296047922614,"ZNF720","zinc finger protein 720",TRUE
+"228029_at",0.185043390364233,0.00179036037499185,-3.54770069934473,-1.1697781467224,-1.6837177833663,"ZNF721","zinc finger protein 721",TRUE
+"215978_x_at",0.943988850936011,0.749634459149292,-0.323119484395312,-5.88895861927076,-0.121817901107356,"ZNF721","zinc finger protein 721",TRUE
+"222136_x_at",0.246981768922011,0.00339698747561687,-3.28014089865405,-1.73256637793116,-2.43925845041653,"ZNF729///ZNF43","zinc finger protein 729///zinc finger protein 43",TRUE
+"1559274_at",0.90998880119877,0.625400431282109,0.49510485112895,-5.82099040693508,0.416105563520794,"ZNF732","zinc finger protein 732",TRUE
+"1559275_x_at",0.917724754910316,0.65082652026257,-0.458828539351242,-5.8376621279599,-0.325828751289395,"ZNF732","zinc finger protein 732",TRUE
+"1554996_at",0.688234475234403,0.157686447886489,1.46234756211985,-4.94856080471754,0.97170399930926,"ZNF733P///LOC285902///ZNF479///ZNF273","zinc finger protein 733, pseudogene///uncharacterized LOC285902///zinc finger protein 479///zinc finger protein 273",TRUE
+"244551_at",0.468735421183467,0.0250935268002562,-2.40249980240585,-3.46225240079654,-2.85391610231341,"ZNF736","zinc finger protein 736",TRUE
+"235027_at",0.610033432202476,0.082600200456933,-1.81807125165184,-4.44646939349606,-1.33803895549358,"ZNF736","zinc finger protein 736",TRUE
+"1569637_at",0.984916798133038,0.925751064493273,0.0942584650240096,-5.93535701761438,0.0866486153414492,"ZNF736","zinc finger protein 736",TRUE
+"241826_x_at",0.75959865506602,0.25736736520417,-1.16258514625651,-5.30197268817258,-1.15939825849779,"ZNF738","zinc finger protein 738",TRUE
+"229700_at",0.985709215004606,0.930885528716748,-0.0877221489455938,-5.93593613943388,-0.0659996606246942,"ZNF738","zinc finger protein 738",TRUE
+"235997_at",0.686998148149102,0.155539063802422,-1.47030147989925,-4.93827236103711,-1.58300989764442,"ZNF74","zinc finger protein 74",TRUE
+"205881_at",0.971943273048675,0.865691696587551,-0.171108209656596,-5.92543328991415,-0.0637611209666824,"ZNF74","zinc finger protein 74",TRUE
+"236810_at",0.686998148149102,0.15560156194443,1.47006873267788,-4.93857406275117,0.991528816087535,"ZNF740","zinc finger protein 740",TRUE
+"227331_at",0.912686134671598,0.633577054608418,-0.483367678407152,-5.82652023585358,-0.1672699561865,"ZNF740","zinc finger protein 740",TRUE
+"1558277_at",0.9832781796011,0.918530307565658,-0.103457881381988,-5.93447152868817,-0.0463509283061203,"ZNF740","zinc finger protein 740",TRUE
+"225848_at",0.0937850904634684,0.000382516235452281,-4.18144456448918,0.191093307087289,-1.42469408489625,"ZNF746","zinc finger protein 746",TRUE
+"1570373_at",0.839519981963042,0.426481039259868,0.810130510787136,-5.62497636024748,0.247139671651166,"ZNF746","zinc finger protein 746",TRUE
+"238606_at",0.769847953580141,0.277939045896215,-1.11228449029031,-5.35442180870235,-0.57169780814778,"ZNF747","zinc finger protein 747",TRUE
+"206180_x_at",0.812302873476553,0.356808179252254,-0.941087295498004,-5.51728598042403,-0.360227066467361,"ZNF747","zinc finger protein 747",TRUE
+"228856_at",0.820291269575398,0.378940761613373,-0.897807869729452,-5.55452758443629,-0.651734865067834,"ZNF747","zinc finger protein 747",TRUE
+"215289_at",0.837580896549225,0.421555575880047,0.818915955934045,-5.61822196909711,0.550362210762719,"ZNF749","zinc finger protein 749",TRUE
+"219995_s_at",0.918041148686074,0.651698441574619,0.457595828963499,-5.83820684055833,0.633138434540582,"ZNF750","zinc finger protein 750",TRUE
+"239204_at",0.581852599439475,0.064152805610967,-1.94832654972817,-4.24273427046752,-1.4215200965599,"ZNF75A","zinc finger protein 75a",TRUE
+"227670_at",0.898407712535128,0.587764862869346,-0.550083975838326,-5.79336691816636,-0.281593976653895,"ZNF75A","zinc finger protein 75a",TRUE
+"242633_x_at",0.953307828415665,0.785121137736241,-0.275980048743129,-5.90265426070321,-0.0956421882494922,"ZNF75A","zinc finger protein 75a",TRUE
+"213659_at",0.343377371300472,0.00862290134056786,-2.88166296695915,-2.54545721615067,-1.30988855468168,"ZNF75D","zinc finger protein 75D",TRUE
+"214813_at",0.643688366500038,0.114659091443745,-1.64223858282944,-4.70509765422301,-0.734665037047339,"ZNF75D","zinc finger protein 75D",TRUE
+"1553225_s_at",0.865345395265289,0.495125980544622,-0.693624238680993,-5.70802844782437,-0.399655345841667,"ZNF75D","zinc finger protein 75D",TRUE
+"207494_s_at",0.819203514175924,0.376058386204301,-0.90334754188424,-5.54985100249836,-0.730423427314524,"ZNF76","zinc finger protein 76",TRUE
+"1558755_x_at",0.856631989847095,0.470684878228402,0.733933835801393,-5.68067397950852,0.42607376639035,"ZNF763","zinc finger protein 763",TRUE
+"1558754_at",0.96351240321323,0.83382798105737,0.212281761448217,-5.91775849307931,0.275078047906229,"ZNF763","zinc finger protein 763",TRUE
+"57516_at",0.123006402791315,0.000699679767134866,-3.93464015716387,-0.341571409603701,-1.6857425426279,"ZNF764","zinc finger protein 764",TRUE
+"222120_at",0.505067985736837,0.0329004023584135,-2.27541949241473,-3.69060499308398,-0.606501776359124,"ZNF764","zinc finger protein 764",TRUE
+"223897_at",0.946249475978621,0.756292759877474,-0.314220974564707,-5.89170747828205,-0.185988887019955,"ZNF765","zinc finger protein 765",TRUE
+"1558943_x_at",0.952697366942815,0.783403633790528,-0.278246017388415,-5.90204483434016,-0.0981126179398473,"ZNF765","zinc finger protein 765",TRUE
+"1558942_at",0.989524702314661,0.94896640587411,0.0647338685290236,-5.93764266158737,0.0228930524556041,"ZNF765","zinc finger protein 765",TRUE
+"227284_at",0.919375181609246,0.65733266525404,-0.449647467567522,-5.84168458485163,-0.166852073683852,"ZNF766","zinc finger protein 766",TRUE
+"219627_at",0.528176582660474,0.0407263602829927,-2.17322926055206,-3.86889065759108,-0.915802418256712,"ZNF767P","zinc finger family member 767, pseudogene",TRUE
+"218916_at",0.400714774069951,0.0143062686599825,-2.65831243239906,-2.98268771165369,-1.05963002753317,"ZNF768///ZNF747","zinc finger protein 768///zinc finger protein 747",TRUE
+"229000_at",0.00206433892657929,3.39808876803175e-07,-7.15920871691385,6.2403278279078,-3.52023142061423,"ZNF77","zinc finger protein 77",TRUE
+"1558673_s_at",0.609499207369658,0.0816852736407447,-1.82390088598199,-4.43756508719455,-0.747259553580196,"ZNF77","zinc finger protein 77",TRUE
+"238687_x_at",0.792716268502624,0.324455372114213,1.00774690586893,-5.45679145447964,0.507339812824585,"ZNF770","zinc finger protein 770",TRUE
+"225517_at",0.945266590617502,0.752772796014205,-0.318921971120154,-5.89026475353295,-0.111451558918555,"ZNF770","zinc finger protein 770",TRUE
+"220608_s_at",0.970893641742918,0.860976884199305,0.177179784306398,-5.92440482256311,0.0759323316646059,"ZNF770","zinc finger protein 770",TRUE
+"219781_s_at",0.0463876491281208,5.76929152393637e-05,-4.95461164350601,1.85410821681182,-1.55688570370473,"ZNF771","zinc finger protein 771",TRUE
+"219782_s_at",0.933128615754618,0.704501438129582,0.384188076221087,-5.86804731810313,0.318520869972108,"ZNF771","zinc finger protein 771",TRUE
+"232561_at",0.976746068767032,0.88904229128372,-0.141130298341529,-5.92998692753816,-0.0497816922656784,"ZNF771","zinc finger protein 771",TRUE
+"221968_s_at",0.978940727614819,0.897563761780171,0.130224655757031,-5.93142701365878,0.041502836762151,"ZNF771","zinc finger protein 771",TRUE
+"219780_at",0.980815405241671,0.909884557279612,-0.114484889490226,-5.93330166226816,-0.0874145228124816,"ZNF771","zinc finger protein 771",TRUE
+"228294_s_at",0.809707978333974,0.35308065317406,-0.948551732240777,-5.51070001290602,-0.44674564588508,"ZNF775","zinc finger protein 775",TRUE
+"229931_at",0.984244246588495,0.923465064370547,-0.0971699436360401,-5.93508567783102,-0.06154413418286,"ZNF775","zinc finger protein 775",TRUE
+"228226_s_at",0.991689960875868,0.960802371819131,0.0497055820202268,-5.93848019236181,0.0188953630880242,"ZNF775","zinc finger protein 775",TRUE
+"230517_at",0.998140407342617,0.991495976492476,-0.0107793296217235,-5.93962688711995,-0.00546315016752263,"ZNF775","zinc finger protein 775",TRUE
+"228652_at",0.634743115037769,0.105693610129881,-1.68669222219062,-4.64157209439385,-0.665243478865898,"ZNF776","zinc finger protein 776",TRUE
+"239838_at",0.761748280722165,0.261129938458835,1.15316935274819,-5.31194597648344,0.34162949842838,"ZNF776","zinc finger protein 776",TRUE
+"226983_at",0.429284714913652,0.0189107688301184,-2.53247115959586,-3.22170789271818,-1.61821882840407,"ZNF777","zinc finger protein 777",TRUE
+"1553172_at",0.564004192185035,0.055951263823816,-2.01718615505586,-4.13112701007903,-0.702083632326366,"ZNF777","zinc finger protein 777",TRUE
+"228687_at",0.609827382478528,0.0819086597964594,1.82247233687829,-4.43974897990954,1.09362196412981,"ZNF777","zinc finger protein 777",TRUE
+"237855_at",0.961123450264505,0.822507152545792,0.226997328039395,-5.91461731282871,0.110603459552536,"ZNF777","zinc finger protein 777",TRUE
+"1556581_at",0.682504456039784,0.15008232418777,-1.49092198062719,-4.91138983686193,-0.412699461251026,"ZNF778","zinc finger protein 778",TRUE
+"239441_at",0.823332010829602,0.39015471547479,0.876514740878466,-5.57225514389714,0.515673457919969,"ZNF780A","zinc finger protein 780A",TRUE
+"238907_at",0.868397087637799,0.503846828790271,-0.679519154764468,-5.7172521646848,-0.268884842319857,"ZNF780A","zinc finger protein 780A",TRUE
+"215570_s_at",0.906053610890338,0.612603289827538,0.513617911636187,-5.81200501056408,0.20180388564583,"ZNF780A///ZNF780B","zinc finger protein 780A///zinc finger protein 780B",TRUE
+"243294_at",0.752235383514782,0.245553417032539,1.19283071353333,-5.26945663096805,0.808590424854312,"ZNF780B","zinc finger protein 780B",TRUE
+"242969_at",0.773234064853267,0.284208297012436,-1.09749803753187,-5.36944916350527,-0.459764388324253,"ZNF780B","zinc finger protein 780B",TRUE
+"214899_at",0.820536502908875,0.380270638947139,0.895261308955089,-5.55666846070651,0.459981776962063,"ZNF780B","zinc finger protein 780B",TRUE
+"244818_at",0.947062793209778,0.759597165136818,-0.309814429194749,-5.89304056663552,-0.130383080647479,"ZNF780B","zinc finger protein 780B",TRUE
+"1559789_a_at",0.837015771520825,0.419098186733407,0.823323200725902,-5.61480789296798,0.686613040123584,"ZNF781","zinc finger protein 781",TRUE
+"1552785_at",0.998140407342617,0.991513521784952,-0.0107570890760639,-5.93962712041298,-0.0087067035777304,"ZNF781","zinc finger protein 781",TRUE
+"1569443_s_at",0.552420073963858,0.0502069927598136,-2.07098285805001,-4.04214478563661,-1.17811247208964,"ZNF782","zinc finger protein 782",TRUE
+"235290_at",0.623667408398064,0.0951807337620765,-1.74309104654644,-4.5591421993844,-1.00055064272844,"ZNF782","zinc finger protein 782",TRUE
+"238109_at",0.68033297785336,0.147594112306831,1.50052795501071,-4.89876391329145,0.80008039152137,"ZNF782","zinc finger protein 782",TRUE
+"221876_at",0.861962516141708,0.484314600068979,-0.711309150924994,-5.69620839071399,-0.308327085709109,"ZNF783","zinc finger family member 783",TRUE
+"78495_at",0.937113154905832,0.720438791900748,-0.362465392496881,-5.87589437036222,-0.159269241875807,"ZNF783","zinc finger family member 783",TRUE
+"1556224_a_at",0.689848451630875,0.158987526487898,-1.45757093925724,-4.95471764548668,-0.817853606326913,"ZNF783///LOC155060","zinc finger family member 783///AI894139 pseudogene",TRUE
+"1569473_s_at",0.873330973137109,0.518480889328417,0.656155362287557,-5.73213129855949,0.242356813104171,"ZNF783///LOC155060","zinc finger family member 783///AI894139 pseudogene",TRUE
+"228364_at",0.271686396298414,0.00429165057308625,-3.18135188515323,-1.93734616193083,-1.20087174124988,"ZNF784","zinc finger protein 784",TRUE
+"1554769_at",0.912722788750542,0.634193606778237,-0.482485452026404,-5.82693064640802,-0.285172567600466,"ZNF785","zinc finger protein 785",TRUE
+"242272_at",0.931370027472813,0.695975042360682,-0.39588666574761,-5.86363486557557,-0.28203731767063,"ZNF785","zinc finger protein 785",TRUE
+"1554770_x_at",0.986455005400648,0.937046384118126,-0.079884347161073,-5.93657576095848,-0.0695624820152663,"ZNF785","zinc finger protein 785",TRUE
+"239083_at",0.515810181619652,0.0361610363523867,-2.23040739282342,-3.76974504293543,-0.747252320723765,"ZNF786","zinc finger protein 786",TRUE
+"1557888_at",0.824127945402254,0.391541792588367,-0.873908811586642,-5.57439759837392,-0.414709493648644,"ZNF787","zinc finger protein 787",TRUE
+"213402_at",0.97897951922649,0.898082315109343,-0.129561554884094,-5.93151084914647,-0.0538094744117812,"ZNF787","zinc finger protein 787",TRUE
+"244552_at",0.812302873476553,0.357875022146629,0.938960603962274,-5.51915364852222,1.11969558588116,"ZNF788","zinc finger family member 788",TRUE
+"242307_at",0.652992478303356,0.122299044197189,1.60660889514899,-4.75507289864781,0.860988340500718,"ZNF789","zinc finger protein 789",TRUE
+"1569194_at",0.730768621354511,0.213362070931717,1.28122580501455,-5.17029327612123,0.509314374500581,"ZNF789","zinc finger protein 789",TRUE
+"1558762_a_at",0.771623843789204,0.281043099442759,1.1049334600974,-5.36191492706105,0.553103763541935,"ZNF789","zinc finger protein 789",TRUE
+"235231_at",0.960138290470901,0.819455730387412,0.230972416708128,-5.91373286459423,0.124464911802559,"ZNF789","zinc finger protein 789",TRUE
+"214138_at",0.698391916012681,0.169456347613557,-1.42024271568438,-5.0022658087791,-0.542503172071288,"ZNF79","zinc finger protein 79",TRUE
+"216486_x_at",0.842224301155785,0.435767419815289,-0.793736773410921,-5.63739714219418,-0.202678109896858,"ZNF79","zinc finger protein 79",TRUE
+"216482_x_at",0.898275196327427,0.587410755571052,0.550609225815368,-5.79308938309013,0.19818343194693,"ZNF79","zinc finger protein 79",TRUE
+"1558809_s_at",0.95004228833184,0.77320497020924,0.291732653377392,-5.89831534516031,0.207116731413198,"ZNF790-AS1","ZNF790 antisense RNA 1",TRUE
+"235779_at",0.997519336907877,0.987411575639599,0.0159569229090466,-5.93955946384528,0.0186730559638004,"ZNF790-AS1","ZNF790 antisense RNA 1",TRUE
+"227122_at",0.808257777979515,0.350740028904637,-0.95326612538357,-5.50651587696277,-0.378375824282832,"ZNF791","zinc finger protein 791",TRUE
+"1553704_x_at",0.94079969729523,0.735043317071055,0.342714466510076,-5.88263771114905,0.140007947072847,"ZNF791","zinc finger protein 791",TRUE
+"1553703_at",0.975398143273847,0.881963209542675,0.150203283746636,-5.92870080715376,0.0558892823421786,"ZNF791","zinc finger protein 791",TRUE
+"235052_at",0.907964244160782,0.618198602690032,-0.50550141963256,-5.81598400082552,-0.402176015700248,"ZNF792","zinc finger protein 792",TRUE
+"244180_at",0.771158062322823,0.280129562101619,-1.1070907516236,-5.35972050890561,-0.776929775771324,"ZNF793","zinc finger protein 793",TRUE
+"229205_at",0.716961986612042,0.192894573810025,-1.34291822287859,-5.09751454063835,-1.144564156216,"ZNF793-AS1","ZNF793 antisense RNA 1 (head to head)",TRUE
+"214901_at",0.807944276806637,0.349641156058992,0.955486784472668,-5.50453840843057,0.326600262627538,"ZNF8","zinc finger protein 8",TRUE
+"207272_at",0.989930879646579,0.950913027874501,0.0622612608741831,-5.9377955741288,0.068778427152183,"ZNF80","zinc finger protein 80",TRUE
+"236531_at",0.910057872239721,0.625630457135334,0.494773701476116,-5.82114820082737,0.139573566088668,"ZNF800","zinc finger protein 800",TRUE
+"227101_at",0.933609099853387,0.706315552342509,0.381706114310128,-5.86896668505857,0.12567937780455,"ZNF800","zinc finger protein 800",TRUE
+"227104_x_at",0.986421906591669,0.936401293524111,-0.0807047784238107,-5.93651160918781,-0.0517398693026028,"ZNF800","zinc finger protein 800",TRUE
+"227097_at",0.998870448604467,0.995605911534103,-0.0055696724279612,-5.9396683714528,-0.00381148249431984,"ZNF800","zinc finger protein 800",TRUE
+"215767_at",0.686025661550069,0.154280137071066,1.4750060436309,-4.93216572782766,1.70831619599143,"ZNF804A","zinc finger protein 804A",TRUE
+"1564022_at",0.979588787486838,0.902234382869908,0.124254210499818,-5.93216645670906,0.0900689616816752,"ZNF804B","zinc finger protein 804B",TRUE
+"238436_s_at",0.767945391174396,0.270442804921054,-1.13028709507076,-5.33588545643562,-0.454096787349441,"ZNF805","zinc finger protein 805",TRUE
+"235398_at",0.812302873476553,0.36054123797424,-0.933664222522984,-5.52378808292318,-0.467439543862504,"ZNF805","zinc finger protein 805",TRUE
+"238437_at",0.861962516141708,0.484336897066992,-0.711272445158309,-5.6962332173716,-0.36280888427958,"ZNF805","zinc finger protein 805",TRUE
+"236328_at",0.854763246850622,0.466629600219431,0.7407395494357,-5.67591072879499,0.392416492780296,"ZNF806///ZNF285","zinc finger protein 806///zinc finger protein 285",TRUE
+"1554476_x_at",0.963737076458538,0.834269897771165,-0.211708321328686,-5.91787665816427,-0.0652626234386107,"ZNF808","zinc finger protein 808",TRUE
+"240079_at",0.51531387545335,0.0359233728164482,-2.2335605230025,-3.764232084996,-1.34837104645686,"ZNF81","zinc finger protein 81",TRUE
+"234111_at",0.760563533925384,0.259720260654917,-1.15668521746944,-5.30823027135122,-0.340276910507388,"ZNF81","zinc finger protein 81",TRUE
+"1561039_a_at",0.850493643619556,0.453192168508681,0.763545871482223,-5.65964527960048,0.483911391322221,"ZNF81","zinc finger protein 81",TRUE
+"215901_at",0.864894115958506,0.49369246656849,0.695956296755624,-5.70648601764675,0.553707194803471,"ZNF81","zinc finger protein 81",TRUE
+"242083_at",0.94895689004559,0.768218973834995,-0.298346100767352,-5.89642254780188,-0.130314612897361,"ZNF81","zinc finger protein 81",TRUE
+"1561038_at",0.972438691973544,0.867217890844775,-0.169144249639545,-5.92575831259732,-0.111461305312883,"ZNF81","zinc finger protein 81",TRUE
+"217665_at",0.791211889207316,0.321586846793655,-1.01387479294009,-5.45104158181812,-0.754680913119299,"ZNF813","zinc finger protein 813",TRUE
+"222135_at",0.559167054471987,0.0528912142938166,2.0451957662988,-4.08498989378825,1.6350798840662,"ZNF814","zinc finger protein 814",TRUE
+"241912_at",0.830592576740524,0.403163234266729,-0.852306223283667,-5.59192958217243,-0.601880873163916,"ZNF814","zinc finger protein 814",TRUE
+"1556204_a_at",0.831943055644609,0.407991728806827,0.843448310067356,-5.59900017345599,0.53136051354968,"ZNF814","zinc finger protein 814",TRUE
+"1557248_at",0.852153111602676,0.457846492568566,-0.755601167549894,-5.66536442013542,-0.591701431734124,"ZNF814","zinc finger protein 814",TRUE
+"60794_f_at",0.984161165881616,0.922838704764707,-0.0979678322577915,-5.93500987775461,-0.061404956380601,"ZNF814","zinc finger protein 814",TRUE
+"1558888_x_at",0.659642261650716,0.127512740071082,-1.58334795463291,-4.78724040320436,-1.64686824271628,"ZNF816-ZNF321P///ZNF321P","ZNF816-ZNF321P readthrough///zinc finger protein 321, pseudogene",TRUE
+"1558887_at",0.683300986833698,0.152394553881118,-1.48211105790548,-4.92291339748228,-1.74916722960578,"ZNF816-ZNF321P///ZNF321P","ZNF816-ZNF321P readthrough///zinc finger protein 321, pseudogene",TRUE
+"217541_x_at",0.907189812622248,0.615992301619424,-0.508697715384855,-5.81442444209246,-0.151404239800424,"ZNF816-ZNF321P///ZNF816","ZNF816-ZNF321P readthrough///zinc finger protein 816",TRUE
+"238149_at",0.973071267819624,0.870449422688523,0.164988038144186,-5.92643380013786,0.134692232774374,"ZNF818P","zinc finger protein 818, pseudogene",TRUE
+"238148_s_at",0.995261077491356,0.978056383448078,0.0278179583632331,-5.93930657942582,0.0169403569677193,"ZNF818P","zinc finger protein 818, pseudogene",TRUE
+"41397_at",0.599731655615302,0.0761746485390271,-1.86026202031276,-4.38156660829995,-1.2082070039011,"ZNF821","zinc finger protein 821",TRUE
+"205494_at",0.60998004334651,0.0821014621099707,-1.82124208277385,-4.4416287431392,-1.45782951699248,"ZNF821","zinc finger protein 821",TRUE
+"242704_at",0.856857560656867,0.471124694504762,-0.733197806315771,-5.68118661887382,-0.46927082324157,"ZNF821","zinc finger protein 821",TRUE
+"229732_at",0.973433731874338,0.871650036155603,-0.163444639397264,-5.92668037317269,-0.0697514366662837,"ZNF823","zinc finger protein 823",TRUE
+"1569191_at",0.64513208805899,0.11614950834313,-1.63513474235725,-4.71512905861935,-1.46233999768414,"ZNF826P","zinc finger protein 826, pseudogene",TRUE
+"1560853_x_at",0.988788646552704,0.946090338468371,0.0683878233931855,-5.93740579464002,0.0664036377685191,"ZNF826P","zinc finger protein 826, pseudogene",TRUE
+"228046_at",0.747587302711183,0.239392889644077,1.20903669611661,-5.25173495514223,1.19188148905693,"ZNF827","zinc finger protein 827",TRUE
+"243617_at",0.81479942420583,0.36565009002861,0.923588478429498,-5.53253799866264,0.811315566408081,"ZNF827","zinc finger protein 827",TRUE
+"231902_at",0.826140850652187,0.394302503857826,0.868739966844623,-5.57862960906359,0.619222199488163,"ZNF827","zinc finger protein 827",TRUE
+"226764_at",0.837368340567858,0.42128099273037,0.819407610070261,-5.61784195959847,0.857716439719215,"ZNF827","zinc finger protein 827",TRUE
+"243618_s_at",0.871744769522775,0.51429755868063,0.662796253704702,-5.7279528074838,0.706244051748293,"ZNF827","zinc finger protein 827",TRUE
+"238952_x_at",0.663707160474585,0.131600353483401,-1.56565790038768,-4.8114583397643,-0.903114867454784,"ZNF829","zinc finger protein 829",TRUE
+"237306_at",0.955816406528307,0.798525775908979,0.258344397513774,-5.90722817861122,0.118593685701745,"ZNF829","zinc finger protein 829",TRUE
+"236429_at",0.947778780715578,0.761367596494996,0.307456072851408,-5.89374636434794,0.148691339483694,"ZNF83","zinc finger protein 83",TRUE
+"221645_s_at",0.969450447163359,0.854555707309503,-0.185459781497399,-5.92294465547656,-0.0848157769045699,"ZNF83","zinc finger protein 83",TRUE
+"226315_at",0.660460734341314,0.128552284169204,-1.57880496217325,-4.79348015984917,-0.485389538232081,"ZNF830","zinc finger protein 830",TRUE
+"226323_at",0.675622576285316,0.142024856907594,-1.5225179771988,-4.86961643701467,-0.564566860905131,"ZNF830","zinc finger protein 830",TRUE
+"1558826_at",0.65284137151906,0.122220384556917,1.6069661181118,-4.75457605347628,1.26267825278389,"ZNF831","zinc finger protein 831",TRUE
+"1558827_a_at",0.788413816943444,0.314594606775977,1.02897368168074,-5.43673963207707,0.701265999257635,"ZNF831","zinc finger protein 831",TRUE
+"215826_x_at",0.99176128617116,0.961813561834072,-0.0484222542021837,-5.93854152119332,-0.0503518635704645,"ZNF835","zinc finger protein 835",TRUE
+"1569076_a_at",0.822812833182588,0.387865703962522,-0.880828351721907,-5.56869571534698,-0.836357929547054,"ZNF836","zinc finger protein 836",TRUE
+"1569077_x_at",0.823074246722209,0.389708967703442,-0.877353453401972,-5.5715643400351,-0.264774819993848,"ZNF836","zinc finger protein 836",TRUE
+"241277_x_at",0.500677386446044,0.031998360558845,-2.28859176922723,-3.66726857318676,-0.843042741083758,"ZNF837","zinc finger protein 837",TRUE
+"1556822_s_at",0.995126858395038,0.977619757451604,-0.0283716235751907,-5.93929142736274,-0.0173497640555751,"ZNF837","zinc finger protein 837",TRUE
+"221709_s_at",0.821424121108148,0.383407562445846,-0.88927753353136,-5.56167682715673,-0.388923869852659,"ZNF839","zinc finger protein 839",TRUE
+"219086_at",0.861665593344139,0.483694547431865,-0.712330286677003,-5.69551723670534,-0.202757553878428,"ZNF839","zinc finger protein 839",TRUE
+"228630_at",0.680708651141727,0.148417655607966,-1.49733405698463,-4.90296914013664,-0.767316175121003,"ZNF84","zinc finger protein 84",TRUE
+"204453_at",0.772420279152863,0.28276184997035,-1.10088842965133,-5.36601932262316,-0.468981664869776,"ZNF84","zinc finger protein 84",TRUE
+"1555078_at",0.596689559015396,0.0730542278564071,1.88188036180027,-4.34790164107614,0.736347919076623,"ZNF843","zinc finger protein 843",TRUE
+"1564362_x_at",0.817916967564753,0.37100241441532,0.913132788449345,-5.54152541192878,0.230683849191431,"ZNF843","zinc finger protein 843",TRUE
+"1558537_x_at",0.791980119714276,0.322745478689598,1.01139509790136,-5.45337211268455,0.666846985760039,"ZNF844","zinc finger protein 844",TRUE
+"228346_at",0.914910510855952,0.641692304766588,0.471786310165495,-5.83184949067525,0.534159648087496,"ZNF844","zinc finger protein 844",TRUE
+"1554445_at",0.523176111047337,0.0387059418232552,-2.19777629499738,-3.82651973732641,-2.17313222690257,"ZNF85","zinc finger protein 85",TRUE
+"206572_x_at",0.547343369043481,0.0478751458543147,-2.0944069953078,-4.00292392747772,-0.922798415754546,"ZNF85","zinc finger protein 85",TRUE
+"244640_at",0.849276510852753,0.450129736816676,-0.768800160434516,-5.65583182555701,-0.479991636813253,"ZNF850","zinc finger protein 850",TRUE
+"1564662_at",0.950214160603623,0.774066994940834,-0.290590614050437,-5.89863794123047,-0.284653211240581,"ZNF852","zinc finger protein 852",TRUE
+"228270_at",0.841550580403629,0.433327361501662,0.798023212518776,-5.6341725474373,0.730457932226541,"ZNF853","zinc finger protein 853",TRUE
+"232884_s_at",0.989638901366417,0.949920417018709,-0.0635220287675101,-5.93771834866099,-0.098321669149585,"ZNF853","zinc finger protein 853",TRUE
+"226808_at",0.536559328842429,0.0433665846016885,-2.14276250065134,-3.92106787629786,-0.978658695678917,"ZNF862","zinc finger protein 862",TRUE
+"213444_at",0.9116561917482,0.630781046800812,-0.487373395252633,-5.82464756300158,-0.393535469602027,"ZNF862","zinc finger protein 862",TRUE
+"238665_at",0.398934416346185,0.01405739170705,-2.66615630580486,-2.96760356357029,-1.84423113878839,"ZNF865","zinc finger protein 865",TRUE
+"241964_at",0.740610299769501,0.230104300211234,1.23407686046499,-5.22394582695415,0.861693728417983,"ZNF865","zinc finger protein 865",TRUE
+"1569468_at",0.916912399329188,0.648524616148698,0.462086417426677,-5.83621561859994,0.506741664156967,"ZNF876P","zinc finger protein 876, pseudogene",TRUE
+"230421_at",0.894978775129642,0.57239354285323,-0.573031658579291,-5.78100207444148,-0.263017180581276,"ZNF879","zinc finger protein 879",TRUE
+"235913_at",0.795635030181504,0.327858385550787,1.00052590714013,-5.46352645144697,1.21572122168345,"ZNF880","zinc finger protein 880",TRUE
+"232315_at",0.960138290470901,0.819496104411722,0.23091979674839,-5.91374467218264,0.36996131401319,"ZNF880","zinc finger protein 880",TRUE
+"230876_at",0.890816525789205,0.559632183924023,0.592321418330642,-5.77022969721066,0.881331077236629,"ZNF883","zinc finger protein 883",TRUE
+"232863_at",0.90227173306771,0.601134932244307,0.530364400347426,-5.80360016294471,0.273337079245111,"ZNF890P///ZNF815P","zinc finger protein 890, pseudogene///zinc finger protein 815, pseudogene",TRUE
+"1569283_at",0.99164669139131,0.960570353940405,0.0500000539932904,-5.93846589365014,0.024576695878423,"ZNF891","zinc finger protein 891",TRUE
+"1562133_x_at",0.986342822130003,0.935257845494518,0.0821591644172175,-5.93639627685284,0.0549537554987216,"ZNF90","zinc finger protein 90",TRUE
+"244259_s_at",0.635821858586292,0.106871566171157,1.68067377806985,-4.65024798709192,0.643426209966106,"ZNF91","zinc finger protein 91",TRUE
+"233671_at",0.812302873476553,0.357484193252051,0.939739203640552,-5.51847032955742,0.5765661007294,"ZNF91","zinc finger protein 91",TRUE
+"1569277_at",0.896428361916712,0.58068913586349,0.560609438846078,-5.78775635892415,0.261087773715827,"ZNF91","zinc finger protein 91",TRUE
+"233672_s_at",0.910860516303107,0.628102081390113,0.491219030581231,-5.8228355182314,0.180145205771144,"ZNF91","zinc finger protein 91",TRUE
+"236128_at",0.962901358483638,0.831731915081971,-0.215002654735024,-5.91719347899052,-0.109182044410014,"ZNF91","zinc finger protein 91",TRUE
+"1562055_at",0.996074388710409,0.980443262500742,-0.0247914203869878,-5.93938412910851,-0.00902687547426773,"ZNF91","zinc finger protein 91",TRUE
+"206059_at",0.998347572104896,0.992156311562222,0.00994228762451661,-5.93963533511988,0.00505052389978822,"ZNF91","zinc finger protein 91",TRUE
+"1564963_x_at",0.296656068775839,0.00537299454698007,-3.08569474137838,-2.1337495687654,-0.936657737022364,"ZNF92","zinc finger protein 92",TRUE
+"235170_at",0.362897608186913,0.0105334888741222,-2.79405979341495,-2.71878385844791,-1.17297516109716,"ZNF92","zinc finger protein 92",TRUE
+"1564962_at",0.757950630724418,0.254076722253047,-1.17090397351498,-5.29310217482141,-0.356895089066482,"ZNF92","zinc finger protein 92",TRUE
+"215758_x_at",0.558021698679157,0.0526464007335696,-2.04749858940346,-4.08117805962917,-0.763343969114239,"ZNF93","zinc finger protein 93",TRUE
+"208119_s_at",0.656641058207682,0.124664472895579,-1.59595513615973,-4.76985128449617,-1.00712842134177,"ZNF93","zinc finger protein 93",TRUE
+"1569241_a_at",0.806735395676905,0.348028674491653,-0.958753959612477,-5.50162137624897,-0.673697189707982,"ZNF93","zinc finger protein 93",TRUE
+"1569240_at",0.886654797568109,0.549652998788724,-0.607564946376886,-5.761473161252,-0.207532075139198,"ZNF93","zinc finger protein 93",TRUE
+"1553883_at",0.48580305784244,0.0282954649523899,-2.34649936135543,-3.56375207292655,-1.992622524804,"ZNF99","zinc finger protein 99",TRUE
+"1553885_x_at",0.923494952314901,0.671791606038501,-0.42938225102348,-5.85028087012229,-0.454310715402853,"ZNF99","zinc finger protein 99",TRUE
+"225076_s_at",0.98539961718117,0.928334314212587,-0.0909694085149414,-5.9356536259568,-0.0437622524613666,"ZNFX1","zinc finger NFX1-type containing 1",TRUE
+"201541_s_at",0.849990777966633,0.452551102818632,-0.764643983849169,-5.65885033494149,-0.37041334974516,"ZNHIT1","zinc finger HIT-type containing 1",TRUE
+"222814_s_at",0.82021287131881,0.37816051321819,-0.899304691396678,-5.55326659229592,-0.307481770489215,"ZNHIT2","zinc finger HIT-type containing 2",TRUE
+"227734_s_at",0.858822368789154,0.474688833741348,-0.727248113486293,-5.68531260402849,-0.385735837123695,"ZNHIT2","zinc finger HIT-type containing 2",TRUE
+"219050_s_at",0.895213601869362,0.573474087434667,-0.571408472536812,-5.78189279138178,-0.378055691594463,"ZNHIT2","zinc finger HIT-type containing 2",TRUE
+"212544_at",0.77204612088057,0.282165257008518,-1.10229046954955,-5.36459822087382,-0.381508461585678,"ZNHIT3","zinc finger HIT-type containing 3",TRUE
+"233005_at",0.84421131646729,0.440889070514988,0.784787420110488,-5.64407684881555,0.362652096220899,"ZNHIT6","zinc finger HIT-type containing 6",TRUE
+"218932_at",0.898098183774511,0.587030802451089,0.551172987332947,-5.79279121281584,0.231650286832586,"ZNHIT6","zinc finger HIT-type containing 6",TRUE
+"234115_s_at",0.562414216355319,0.0549882048425851,2.02585097571627,-4.1168993923339,1.66735923107329,"ZNRD1","zinc ribbon domain containing 1",TRUE
+"234114_at",0.734730148360473,0.219546060991792,1.26349102781492,-5.19067647609429,0.699324738613928,"ZNRD1","zinc ribbon domain containing 1",TRUE
+"227673_at",0.816199380744005,0.367163020832073,-0.92062271953157,-5.53509685827255,-0.609643761589048,"ZNRD1","zinc ribbon domain containing 1",TRUE
+"234530_s_at",0.859276375962637,0.47630707135436,0.724555417470259,-5.68716943242539,0.391517008463289,"ZNRD1","zinc ribbon domain containing 1",TRUE
+"223639_s_at",0.868397087637799,0.504308716669368,-0.678775967763304,-5.71773313221528,-0.266249457869383,"ZNRD1","zinc ribbon domain containing 1",TRUE
+"228009_x_at",0.893623865544737,0.569002643854984,-0.578135581198626,-5.77818537169056,-0.185488706206854,"ZNRD1","zinc ribbon domain containing 1",TRUE
+"242557_at",0.726696341943087,0.206878522310496,-1.30025070390761,-5.14815848565305,-1.09894993266023,"ZNRD1ASP","zinc ribbon domain containing 1 antisense, pseudogene",TRUE
+"234445_at",0.916107385524794,0.646276550188266,-0.465273005981585,-5.83479106365273,-0.307315564696118,"ZNRD1ASP","zinc ribbon domain containing 1 antisense, pseudogene",TRUE
+"234866_s_at",0.967098323798013,0.846327142099971,0.196089889209406,-5.92097263164275,0.159947788660427,"ZNRD1ASP","zinc ribbon domain containing 1 antisense, pseudogene",TRUE
+"225962_at",0.42796179417767,0.0185810953510132,-2.54046828264878,-3.2066910014557,-2.56421164572996,"ZNRF1","zinc and ring finger 1, E3 ubiquitin protein ligase",TRUE
+"223383_at",0.657015752622694,0.125575437701269,-1.59189711639505,-4.77546025569898,-0.94059977269174,"ZNRF1","zinc and ring finger 1, E3 ubiquitin protein ligase",TRUE
+"225959_s_at",0.659642261650716,0.127510262055609,-1.58335882071189,-4.78722546194693,-0.765362723781942,"ZNRF1","zinc and ring finger 1, E3 ubiquitin protein ligase",TRUE
+"231092_s_at",0.673366993714442,0.139452770927267,-1.53291328361568,-4.85572000612676,-0.757535977202799,"ZNRF1","zinc and ring finger 1, E3 ubiquitin protein ligase",TRUE
+"223382_s_at",0.743013407304127,0.233211761915796,-1.22561593353081,-5.23339068536573,-0.641471199520776,"ZNRF1","zinc and ring finger 1, E3 ubiquitin protein ligase",TRUE
+"225960_at",0.986342822130003,0.935172041480196,-0.082268308412006,-5.93638753873258,-0.0510041642231212,"ZNRF1","zinc and ring finger 1, E3 ubiquitin protein ligase",TRUE
+"229188_s_at",0.632216562924782,0.103149215974318,-1.69988872568201,-4.62246682602917,-1.01289255582197,"ZNRF2","zinc and ring finger 2, E3 ubiquitin protein ligase",TRUE
+"226261_at",0.835777619799517,0.415175494353084,-0.83039223204516,-5.6092960383686,-0.51666573559217,"ZNRF2","zinc and ring finger 2, E3 ubiquitin protein ligase",TRUE
+"1556404_a_at",0.84396230746828,0.440236681387075,-0.785923816771151,-5.64323260741992,-0.584009826168151,"ZNRF2P1","zinc and ring finger 2 pseudogene 1",TRUE
+"226360_at",0.997623421895415,0.98820611291506,-0.0149496967362268,-5.9395746259245,-0.00694619474844238,"ZNRF3","zinc and ring finger 3",TRUE
+"215461_at",0.973071267819624,0.870754181057941,-0.164596229986369,-5.92649661422818,-0.0821458782498254,"ZNRF4","zinc and ring finger 4",TRUE
+"237335_at",0.973516231900274,0.872659521117147,0.162147252562281,-5.92688585520851,0.122106967723418,"ZP1","zona pellucida glycoprotein 1",TRUE
+"207933_at",0.995111934465262,0.977470017817889,-0.0285615035564885,-5.93928616219135,-0.0159144383542906,"ZP2","zona pellucida glycoprotein 2",TRUE
+"231756_at",0.690015152288705,0.159591377693678,1.45536476804964,-4.95755577366916,0.377386459689353,"ZP4","zona pellucida glycoprotein 4",TRUE
+"207021_at",0.849935057946582,0.452307057652886,0.765062267392301,-5.65854724749683,0.499600484207644,"ZPBP","zona pellucida binding protein",TRUE
+"231442_at",0.892000472179706,0.562200937746916,0.588420513558572,-5.77243598991004,0.260899267327087,"ZPBP2","zona pellucida binding protein 2",TRUE
+"1569777_a_at",0.635174103121116,0.10595498677871,1.68535190174541,-4.64350626282693,1.27781200303983,"ZPLD1","zona pellucida like domain containing 1",TRUE
+"1561969_at",0.708894565317004,0.181480845245709,1.37958192778116,-5.05290358344022,1.36064128591134,"ZPLD1","zona pellucida like domain containing 1",TRUE
+"200054_at",0.962808206628386,0.830951475427112,-0.216016162904499,-5.91698118510209,-0.0723805035893044,"ZPR1","ZPR1 zinc finger",TRUE
+"225130_at",0.835952408568777,0.416343247600754,0.828283454586942,-5.61094490665508,0.286584782029299,"ZRANB1","zinc finger RANBP2-type containing 1",TRUE
+"225131_at",0.919354071504066,0.656663903273081,0.450589362025029,-5.84127558672967,0.132910741236646,"ZRANB1","zinc finger RANBP2-type containing 1",TRUE
+"225138_at",0.949976632131345,0.772932837169884,0.292093266583241,-5.89821322070859,0.0846739841962574,"ZRANB1","zinc finger RANBP2-type containing 1",TRUE
+"223716_s_at",0.70215456577829,0.173614394577546,1.40592923836687,-5.02022976933266,0.405318450436425,"ZRANB2","zinc finger RANBP2-type containing 2",TRUE
+"223016_x_at",0.859483694145165,0.476921005216468,0.723535253805824,-5.68787120654384,0.223064776096722,"ZRANB2","zinc finger RANBP2-type containing 2",TRUE
+"231030_at",0.917102138198416,0.649464717106696,0.460755283943976,-5.83680785805173,0.161037760551214,"ZRANB2-AS1","ZRANB2 antisense RNA 1",TRUE
+"244092_at",0.909052380289506,0.622040898494584,0.49994772480655,-5.81867098461924,0.163168562404786,"ZRANB3","zinc finger RANBP2-type containing 3",TRUE
+"224124_at",0.926262519929636,0.679614947407357,0.418493556051811,-5.85473891995211,0.218534251775666,"ZRANB3","zinc finger RANBP2-type containing 3",TRUE
+"239538_at",0.968980656821882,0.853609671368962,0.186680786542475,-5.92272370979246,0.103000121858551,"ZRANB3","zinc finger RANBP2-type containing 3",TRUE
+"206512_at",0.820536502908875,0.380291358356042,-0.895221680023224,-5.55670173202253,-0.64998933455498,"ZRSR1///SRP19","zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1///signal recognition particle 19",TRUE
+"208174_x_at",0.54295328972902,0.0462203585782846,-2.11165937674763,-3.97385568303413,-0.556799467377347,"ZRSR2","zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2",TRUE
+"213876_x_at",0.55937703282623,0.0534171582823689,-2.04028051110204,-4.09311661874012,-0.544178066612446,"ZRSR2","zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2",TRUE
+"1562651_at",0.916443520723728,0.647060611296692,0.464161061295157,-5.83528924442774,0.227858216879051,"ZSCAN1","zinc finger and SCAN domain containing 1",TRUE
+"1553875_s_at",0.477266692481162,0.0265049864496219,2.37704629678963,-3.50855254061582,0.927400111165005,"ZSCAN10","zinc finger and SCAN domain containing 10",TRUE
+"1553874_a_at",0.904432955312383,0.608116877953346,-0.520151158855638,-5.80875730557417,-0.168223737919708,"ZSCAN10","zinc finger and SCAN domain containing 10",TRUE
+"217098_s_at",0.700261997243562,0.172033272006868,1.41133938234041,-5.01345742962039,1.03111930971392,"ZSCAN12","zinc finger and SCAN domain containing 12",TRUE
+"206507_at",0.744365670919682,0.235324382658376,1.21991241818174,-5.2397257927789,0.590414015579917,"ZSCAN12","zinc finger and SCAN domain containing 12",TRUE
+"240181_at",0.761685250899646,0.260804930628117,1.15397870473912,-5.31109150158273,1.04730097929725,"ZSCAN12","zinc finger and SCAN domain containing 12",TRUE
+"239157_at",0.725168361556674,0.203541425560375,1.3102235752026,-5.13644489095776,0.883183579994842,"ZSCAN12P1","zinc finger and SCAN domain containing 12 pseudogene 1",TRUE
+"219676_at",0.896428361916712,0.580683674005,-0.560617588227464,-5.78775197494903,-0.166224490331008,"ZSCAN16","zinc finger and SCAN domain containing 16",TRUE
+"236777_at",0.606900628956089,0.0801532444704521,1.83379049626681,-4.42241268351248,1.20859595474478,"ZSCAN16-AS1","ZSCAN16 antisense RNA 1",TRUE
+"1557062_at",0.740610299769501,0.230415680149029,1.23322514540356,-5.22489912616539,0.583540519241877,"ZSCAN16-AS1","ZSCAN16 antisense RNA 1",TRUE
+"244730_x_at",0.841420204214686,0.432490754440701,0.799496308376043,-5.63306059922991,0.354426669173282,"ZSCAN16-AS1","ZSCAN16 antisense RNA 1",TRUE
+"232866_at",0.773162317209202,0.284093844585878,1.09776585213446,-5.36917857499707,0.603511790369605,"ZSCAN18","zinc finger and SCAN domain containing 18",TRUE
+"218312_s_at",0.877857073443889,0.52886382138912,0.63979928640371,-5.7422503808595,0.893058215362997,"ZSCAN18","zinc finger and SCAN domain containing 18",TRUE
+"217593_at",0.989524702314661,0.948509475883375,-0.0653143223233146,-5.93760590216101,-0.0593429823268394,"ZSCAN18","zinc finger and SCAN domain containing 18",TRUE
+"220516_at",0.851497182527604,0.455533472134109,-0.75954327650501,-5.66253369188787,-0.556518104937433,"ZSCAN2","zinc finger and SCAN domain containing 2",TRUE
+"231188_at",0.926430328514448,0.680287883240468,-0.417559366858401,-5.85511615276753,-0.157671237220817,"ZSCAN2","zinc finger and SCAN domain containing 2",TRUE
+"1552498_at",0.697412165374288,0.1678248951778,1.42593565210884,-4.99507942887723,0.897404699119849,"ZSCAN20","zinc finger and SCAN domain containing 20",TRUE
+"1552499_a_at",0.871225851789576,0.511973147223198,0.666499144805758,-5.72560541292303,0.275178160429798,"ZSCAN20","zinc finger and SCAN domain containing 20",TRUE
+"1554790_at",0.949738851691975,0.77243689541909,0.292750558460765,-5.89802675597338,0.205469535021498,"ZSCAN20","zinc finger and SCAN domain containing 20",TRUE
+"223424_s_at",0.999369827418759,0.998091692467057,0.00241884097979936,-5.9396806310446,0.000708557576119873,"ZSCAN21","zinc finger and SCAN domain containing 21",TRUE
+"228769_at",0.839519981963042,0.426347005899553,0.810368742152825,-5.62479410564286,0.270642267046931,"ZSCAN22","zinc finger and SCAN domain containing 22",TRUE
+"1564039_at",0.61190373281876,0.0836462277300719,1.81147440615544,-4.45652077579587,1.39625514447566,"ZSCAN23","zinc finger and SCAN domain containing 23",TRUE
+"1563670_at",0.877857073443889,0.528740825885129,0.639992006490697,-5.74213257855473,0.591416519623488,"ZSCAN23","zinc finger and SCAN domain containing 23",TRUE
+"242621_at",0.971216837324271,0.862430993405735,0.17530651580072,-5.92472595024041,0.0465129667415738,"ZSCAN25","zinc finger and SCAN domain containing 25",TRUE
+"228138_at",0.979963746464018,0.904291008694085,0.121626709302291,-5.93248089591431,0.0344909045804513,"ZSCAN25","zinc finger and SCAN domain containing 25",TRUE
+"213218_at",0.860085676417428,0.47909769615412,0.719924458350928,-5.69034753239449,0.231844030208333,"ZSCAN26","zinc finger and SCAN domain containing 26",TRUE
+"226562_at",0.949347776420105,0.771167903944529,-0.29443300520259,-5.89754757513909,-0.103706036337078,"ZSCAN29","zinc finger and SCAN domain containing 29",TRUE
+"1562988_at",0.631316839203356,0.102522547357398,-1.70318132303898,-4.61768250248393,-1.18265678030107,"ZSCAN30","zinc finger and SCAN domain containing 30",TRUE
+"1557105_a_at",0.704665987011002,0.176620808157271,1.39574972329567,-5.03291416923093,0.790244784698259,"ZSCAN30","zinc finger and SCAN domain containing 30",TRUE
+"1557104_at",0.728385463227073,0.209352275684064,1.29293818021272,-5.1566991465056,1.14888432050215,"ZSCAN30","zinc finger and SCAN domain containing 30",TRUE
+"228130_at",0.789795896476304,0.318294590742509,-1.02095507665677,-5.4443587949987,-0.340524028405738,"ZSCAN30","zinc finger and SCAN domain containing 30",TRUE
+"228125_at",0.851861294910063,0.4569902814999,-0.757059021082411,-5.66431919635099,-0.422090564303748,"ZSCAN30","zinc finger and SCAN domain containing 30",TRUE
+"222016_s_at",0.730382735086021,0.213070043431587,1.28207303392376,-5.1693134615432,0.772973388075962,"ZSCAN31","zinc finger and SCAN domain containing 31",TRUE
+"218937_at",0.542397752248982,0.0454851157800174,-2.11950367876681,-3.96058861762135,-0.50453244402291,"ZSCAN32","zinc finger and SCAN domain containing 32",TRUE
+"220292_at",0.724590981430178,0.201789444358529,-1.31551033804443,-5.13020464765505,-0.442727250750973,"ZSCAN32","zinc finger and SCAN domain containing 32",TRUE
+"1552851_at",0.595936234743389,0.0724497147204263,1.8861614466883,-4.34120248081027,1.59181995775047,"ZSCAN4","zinc finger and SCAN domain containing 4",TRUE
+"1552852_a_at",0.92218645993289,0.668039124253534,-0.434623739143453,-5.84809479399256,-0.28970163776623,"ZSCAN4","zinc finger and SCAN domain containing 4",TRUE
+"1565583_at",0.575270671804438,0.0607899154957034,1.97556058830209,-4.1989066010833,0.825882378903644,"ZSCAN5A","zinc finger and SCAN domain containing 5A",TRUE
+"219904_at",0.757950630724418,0.254473988012433,1.1698954426176,-5.29418053920604,0.518925446481603,"ZSCAN5A","zinc finger and SCAN domain containing 5A",TRUE
+"239406_at",0.647754107214051,0.119185043441964,1.62089977536616,-4.73512966946315,0.858876245619525,"ZSCAN9","zinc finger and SCAN domain containing 9",TRUE
+"205181_at",0.959357995170594,0.81614720279122,-0.235286742825474,-5.91275565180802,-0.101466392922619,"ZSCAN9","zinc finger and SCAN domain containing 9",TRUE
+"223607_x_at",0.698391916012681,0.169509298156292,-1.42005868283872,-5.00249772587463,-0.567827191235534,"ZSWIM1","zinc finger SWIM-type containing 1",TRUE
+"217592_at",0.972278576610345,0.866514905671882,-0.170048790415911,-5.92560908174609,-0.0569798864970066,"ZSWIM1","zinc finger SWIM-type containing 1",TRUE
+"1554932_at",0.870517518639056,0.509327986382473,0.670724428992247,-5.72291155309095,0.374718538790971,"ZSWIM2","zinc finger SWIM-type containing 2",TRUE
+"228223_at",0.963969049134093,0.835051962947198,-0.210693675443326,-5.91808495989436,-0.0937720489861409,"ZSWIM3","zinc finger SWIM-type containing 3",TRUE
+"231915_at",0.847506138098347,0.446163080112819,0.77563814766469,-5.65083198061417,0.427364445890984,"ZSWIM4","zinc finger SWIM-type containing 4",TRUE
+"232336_at",0.683861743647864,0.15286498933505,-1.48033176227304,-4.92523380854736,-0.889115572700979,"ZSWIM5","zinc finger SWIM-type containing 5",TRUE
+"226208_at",0.87293859951272,0.517296947859389,0.658031807529691,-5.73095471703546,0.358424628692351,"ZSWIM6","zinc finger SWIM-type containing 6",TRUE
+"228719_at",0.854184492233394,0.463941467330247,0.745270214064707,-5.67271664740091,0.832638477505942,"ZSWIM7","zinc finger SWIM-type containing 7",TRUE
+"229119_s_at",0.901788521024914,0.599238188656987,0.533148816126572,-5.80217724973215,0.238250326420749,"ZSWIM7","zinc finger SWIM-type containing 7",TRUE
+"212359_s_at",0.851733415458562,0.456658320271838,-0.757624685956193,-5.66391312356093,-0.31653833309483,"ZSWIM8","zinc finger SWIM-type containing 8",TRUE
+"216345_at",0.95168059103032,0.77831027178307,0.284974693885302,-5.90020602785904,0.18171613956373,"ZSWIM8","zinc finger SWIM-type containing 8",TRUE
+"214867_at",0.998870448604467,0.995696192509343,-0.00545523669678174,-5.93966898595195,-0.00261187823887798,"ZSWIM8-AS1///NDST2","ZSWIM8 antisense RNA 1///N-deacetylase and N-sulfotransferase 2",TRUE
+"210593_at",0.89205696974366,0.562417919549071,0.588091427866319,-5.77262147099702,0.301724614729852,"ZSWIM8///SAT1","zinc finger SWIM-type containing 8///spermidine/spermine N1-acetyltransferase 1",TRUE
+"228330_at",0.956960361976289,0.805047374041244,-0.249794866149354,-5.90933758646395,-0.090981144713016,"ZUFSP","zinc finger with UFM1 specific peptidase domain",TRUE
+"204812_at",0.880842449447422,0.536690069792365,0.627586008859267,-5.74964626957062,0.164318368273326,"ZW10","zw10 kinetochore protein",TRUE
+"222606_at",0.919372089675945,0.656964876652981,-0.45016541539595,-5.84145978061988,-0.138668031036243,"ZWILCH","zwilch kinetochore protein",TRUE
+"218349_s_at",0.992768542166819,0.965768143041038,-0.04340417083677,-5.9387659334373,-0.0159612014715549,"ZWILCH","zwilch kinetochore protein",TRUE
+"204026_s_at",0.884562540015067,0.543825975675655,-0.61653326411731,-5.75622106929097,-0.167437710628288,"ZWINT","ZW10 interacting kinetochore protein",TRUE
+"243521_at",0.465776708318531,0.0240600139625696,-2.42199131647464,-3.42661333855838,-0.651070918230173,"ZXDA","zinc finger, X-linked, duplicated A",TRUE
+"228005_at",0.748659576527171,0.241610523454174,-1.20316721774941,-5.2581773832176,-0.347401357021504,"ZXDB","zinc finger, X-linked, duplicated B",TRUE
+"216013_at",0.867580082241907,0.500277139510873,0.68527588536143,-5.71350954368068,0.478066278831836,"ZXDB","zinc finger, X-linked, duplicated B",TRUE
+"215263_at",0.76029267756668,0.258868259163546,-1.15881703716566,-5.30597244373713,-0.368453742779172,"ZXDB///ZXDA","zinc finger, X-linked, duplicated B///zinc finger, X-linked, duplicated A",TRUE
+"216014_s_at",0.958640117088134,0.812577814196202,0.23994636027499,-5.91168002500676,0.161938584078462,"ZXDB///ZXDA","zinc finger, X-linked, duplicated B///zinc finger, X-linked, duplicated A",TRUE
+"218639_s_at",0.854219009487664,0.464910746507991,-0.743634766175747,-5.67387175420303,-0.293597140613365,"ZXDC","ZXD family zinc finger C",TRUE
+"235448_at",0.896421670648767,0.580612357067851,-0.560724000386554,-5.7876947246529,-0.340554906244024,"ZXDC","ZXD family zinc finger C",TRUE
+"225964_at",0.90360437116293,0.604886722844611,-0.524869225843293,-5.8063870678673,-0.146224122880195,"ZXDC","ZXD family zinc finger C",TRUE
+"234991_at",0.911028479628096,0.628863755823392,-0.490124890637032,-5.82335248808373,-0.197076372511442,"ZXDC","ZXD family zinc finger C",TRUE
+"230106_at",0.914910510855952,0.64174407526408,-0.471712639338557,-5.83188298610707,-0.148294504844487,"ZXDC","ZXD family zinc finger C",TRUE
+"230209_at",0.944565550971921,0.750866987506037,-0.321470280497121,-5.88947381638881,-0.117744179453467,"ZXDC","ZXD family zinc finger C",TRUE
+"231517_at",0.877333806479767,0.527061247597846,0.64262616299719,-5.74051900293735,0.702541544874086,"ZYG11A","zyg-11 family member A, cell cycle regulator",TRUE
+"225338_at",0.64513208805899,0.116308761168194,-1.6343802238646,-4.71619255972108,-0.415904418987287,"ZYG11B","zyg-11 family member B, cell cycle regulator",TRUE
+"227918_s_at",0.834881450121645,0.413455180361461,-0.833505683771723,-5.60685443956934,-0.412749083888865,"ZYG11B","zyg-11 family member B, cell cycle regulator",TRUE
+"225350_s_at",0.884214815581313,0.542997652454653,-0.617812258422452,-5.75546600997737,-0.17307015511008,"ZYG11B","zyg-11 family member B, cell cycle regulator",TRUE
+"200808_s_at",0.889452275006221,0.557519806923586,0.595536230469445,-5.76840085638928,0.358257846892517,"ZYX","zyxin",TRUE
+"215706_x_at",0.913627134030439,0.637917269400645,0.477165467661437,-5.82938995357807,0.304640423167506,"ZYX","zyxin",TRUE
+"207189_s_at",0.559624975779079,0.0540740511575834,2.0342017447439,-4.10314923535295,0.715957635561053,"ZZEF1","zinc finger ZZ-type and EF-hand domain containing 1",TRUE
+"207190_at",0.909441642299191,0.624092371633574,-0.496989027853315,-5.8200906284238,-0.235314257032096,"ZZEF1","zinc finger ZZ-type and EF-hand domain containing 1",TRUE
+"212601_at",0.929125618312698,0.688207211530455,0.406593598311122,-5.85948221358191,0.127258028578874,"ZZEF1","zinc finger ZZ-type and EF-hand domain containing 1",TRUE
+"229325_at",0.809422592494997,0.352666940986115,0.949383473245071,-5.50996320372505,0.254512392138853,"ZZZ3","zinc finger ZZ-type containing 3",TRUE
+"212893_at",0.920177077739411,0.660407591579123,0.445321990964774,-5.84355205407101,0.134546679019993,"ZZZ3","zinc finger ZZ-type containing 3",TRUE
diff --git a/Examples/GSE31625_transcriptomics_DEGs.csv b/Examples/GSE31625_transcriptomics_DEGs.csv
new file mode 100644
index 0000000..acd422e
--- /dev/null
+++ b/Examples/GSE31625_transcriptomics_DEGs.csv
@@ -0,0 +1,13300 @@
+"Gene","Log2FC"
+"A1CF",-0.878706018474742
+"A2M",1.15608748643816
+"A4GALT",-0.0988857133336909
+"A4GNT",-0.014621310295249
+"AAAS",-1.33696640162136
+"AACS",-0.168473355262499
+"AADAC",-6.12320605950847
+"AAGAB",-0.708258338774981
+"AAK1",0.158066788343271
+"AAMDC",0.440407759209181
+"AAMP",0.0709419651860603
+"AANAT",0.43508070321215
+"AAR2",0.178590328466097
+"AARS",-0.257526983069926
+"AASDHPPT",0.114043526340535
+"AASS",-0.859779988219253
+"AATF",-0.600770036897385
+"AATK",-0.300070794072499
+"ABAT",2.01808735579684
+"ABCA1",0.0705751544157503
+"ABCA11P",0.954750094323349
+"ABCA12",1.52713231972229
+"ABCA2",0.060792460658276
+"ABCA3",-1.50433556948075
+"ABCA4",1.24710132681883
+"ABCA5",-0.920346787752724
+"ABCA6",-0.228698075463809
+"ABCA7",0.442529172871852
+"ABCA8",-1.2862781971938
+"ABCB1",-1.1708819246287
+"ABCB11",0.634298829869136
+"ABCB4",0.10120775397955
+"ABCB4///ABCB1",-0.944665131729453
+"ABCB6",-1.94830066833565
+"ABCB7",-0.703014475665947
+"ABCB8",-0.248147872216927
+"ABCB8///ASIC3",-0.432468309325297
+"ABCB9",0.356021496145663
+"ABCC1",-0.614464256633108
+"ABCC10",0.0155148825753197
+"ABCC2",-4.95621522100665
+"ABCC3",-0.761364167229518
+"ABCC4",-2.10799205962833
+"ABCC5",0.330100526897189
+"ABCC8",-0.578922631898801
+"ABCC9",-0.433568594106598
+"ABCD1",1.04399768681198
+"ABCD2",-0.384639374418329
+"ABCD3",0.243679265459251
+"ABCD4",-0.488705874561105
+"ABCE1",0.0474664421370374
+"ABCF1",0.297754469174892
+"ABCF2",-0.124579490377982
+"ABCF3",0.190576277662114
+"ABCG1",-0.719976342062395
+"ABCG2",-1.36853065801475
+"ABCG4",-0.151729436644407
+"ABCG5",-0.250989132345147
+"ABHD10",0.0347704129483883
+"ABHD11",0.760678070238573
+"ABHD14A-ACY1///ACY1",-0.0645308342442288
+"ABHD14A///ACY1",0.0483735246779471
+"ABHD17A",-0.0137443849513126
+"ABHD17B",-0.427007843588495
+"ABHD18",-0.222413360971291
+"ABHD2",-0.00381910753506749
+"ABHD3",0.0669137277911807
+"ABHD4",-0.953524009051256
+"ABHD5",0.697752941144034
+"ABHD6",-0.295659367988897
+"ABHD8",2.48885009579004
+"ABI1",0.0751033273122917
+"ABI2",-0.221212619389837
+"ABI3BP",0.0931202137837315
+"ABL1",-0.58563318310328
+"ABL2",0.0603883987428668
+"ABLIM1",-0.13044525848868
+"ABLIM3",2.9769373887742
+"ABO",-0.170991128188202
+"ABR",-0.233253941838079
+"ABT1",0.332559518210562
+"ABTB2",0.525682155308058
+"ACAA1",0.20750020803824
+"ACAA2",-0.433284049547963
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diff --git a/Examples/Inputs/CCLE_metabolomics_20190502.csv b/Examples/Inputs/CCLE_metabolomics_20190502.csv
new file mode 100644
index 0000000..ae54783
--- /dev/null
+++ b/Examples/Inputs/CCLE_metabolomics_20190502.csv
@@ -0,0 +1,929 @@
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+HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE,ACH-000004,5.7706131,6.0587042,6.5450633,5.5138873,5.8387302,6.3183262,6.0587362,5.8403158,7.1333914,5.6706984,5.7125753,7.1110453,6.2981007,6.9198549,6.2715942,5.8312579,5.7207067,5.5443761,5.1176648,6.2469389,5.527735,5.9992594,6.1432667,6.9480535,5.9788566,4.9944298,5.5924647,5.4699589,6.3073894,5.6694614,5.7746991,6.2211332,5.745758,6.2465971,6.0249876,5.7364338,6.3460962,5.8532815,5.3315586,5.6777453,7.0511468,6.118178,7.3131583,6.0845461,5.3727417,5.4693104,6.8097763,5.0669923,6.1666193,5.5755789,4.6049098,4.5118814,6.1575769,5.3418148,6.0273757,5.595196,6.2110379,5.9155961,5.8888329,5.3548924,5.7865061,5.4661218,5.2788089,5.9017279,5.9542944,6.0463709,5.7452901,5.4810017,5.4267912,5.0486766,5.2287728,5.4099784,5.4003681,5.3016378,5.3296284,5.4699912,6.04241,6.1193216,5.2826748,5.6539319,6.0050774,6.3125091,6.5492561,6.2922848,6.1491633,5.8620173,5.2600129,5.2618758,5.0863399,5.3631084,5.6530305,5.3152182,6.938004,5.1929815,5.6212985,5.2639589,5.1770243,5.7806999,6.2228051,5.4326807,4.4383214,5.0319008,5.4093709,5.441416,6.2136853,5.1197764,5.3519912,6.3599032,5.2459274,5.5788171,5.5141612,6.0293098,5.6863821,6.4675665,5.2335087,5.1313893,5.8024773,5.4464907,5.4125424,5.7625485,5.8603737,5.4246529,6.0639999,5.9382601,5.793278,5.7414276,5.3961365,6.1066918,6.8318745,7.046718,6.6687315,6.6119541,6.1810009,5.5336103,5.6681111,5.729481,6.0113544,5.9250604,5.9522868,6.0064798,5.8827471,6.1140061,5.9230694,6.1636033,5.8484062,6.3231179,6.1486149,6.5115192,5.8839763,5.9218423,5.8926979,6.1598218,5.9429411,6.0904047,5.9285576,6.0036912,6.0862958,6.0912683,6.0929338,5.9921158,6.1064755,6.1408851,6.1704086,6.1059361,6.0370604,6.1235571,6.0957945,5.9206522,5.8752002,6.1656207,6.1696125,5.8996675,5.916032,5.9946009,6.0624711,6.1252305,6.4712578,7.2895837,6.2729871,5.9548972,6.2636608,6.0830436,5.8125028,5.8430267,5.9176641,5.7578383,5.8335168,6.1660724,5.3919593,5.6737155,5.743037,6.1137419,5.9220299,5.9213961,6.1929403,5.6133479,5.757999,6.0320774,6.3266654,5.6582822,5.7230918,5.9614331,6.3779857,5.8710761,5.7200342,5.8183737,5.6226995,6.0185739,6.0455032,5.9539905,5.7516315,5.6505291,5.5342585,5.7333231,6.1767396,5.8499188,6.1062439,5.8552448,5.2763218,5.491813,5.6647513,5.912525,5.7417219,5.4166278,5.6811216
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+WM115_SKIN,ACH-000304,6.7254162,6.0387923,5.3541281,6.2080356,6.0950458,5.6634663,5.6888608,6.0282724,5.5948196,6.3505116,6.1893611,5.5235192,6.1079523,6.3984158,5.6976337,6.135232,5.7701591,5.8629607,5.702643,5.7468833,6.1548198,6.1379023,5.8702869,6.2528725,6.7018059,6.0378708,6.1275808,6.5247467,5.4610585,5.9070959,6.0229575,5.7821604,5.973249,6.3383826,5.9074266,6.1259607,6.0495769,6.038667,5.8396649,5.8951136,5.67531,5.6558204,5.6730825,6.1237602,5.8339274,5.9636907,6.1089221,5.7652754,5.2566405,6.1833673,3.6278418,5.1103852,5.74717,6.7775798,5.8688179,5.9648188,5.8185441,5.9657524,5.4702039,5.7490446,5.7469206,6.2142143,5.8243816,5.8284863,5.9964209,5.6586244,5.9514436,6.0967973,5.8280821,5.983638,6.1391709,5.7926358,5.7940657,6.0473202,5.9953503,6.1187287,5.7599727,5.3226773,5.6896806,5.8458605,5.9977907,5.9178754,6.606885,5.152096,5.8728621,5.7080627,5.8114122,5.8140625,5.8293934,5.8035069,5.8229099,5.6531916,5.814963,5.8737436,6.4348765,5.6798104,5.8102516,5.8036377,5.6838967,6.4659269,5.8559891,5.8135059,5.7166372,5.8131852,5.9593322,5.7647598,6.789005,6.1032641,5.8811951,5.5311542,6.1887095,5.830435,6.0694267,6.2595673,5.776208,6.562011,5.774486,5.2439561,5.771055,5.617305,5.5287305,5.7212676,5.5039434,5.4866969,5.7323363,5.638403,5.7343624,5.6079355,5.6231313,5.7377657,5.7601997,5.8206954,5.7353716,5.7776622,5.9845262,5.5366551,6.2976351,6.287442,6.2786049,6.3865595,6.2211384,6.3945828,6.065978,6.3049276,5.9557075,5.786339,5.6148599,5.7130728,5.881505,6.1534015,5.706561,5.7687515,6.1521476,6.1293871,5.8839763,5.7437922,5.8578236,5.9719103,6.0714786,5.9450845,5.7520313,5.7538132,6.0192351,6.0992302,5.9455883,5.5503324,5.9475073,5.8179882,5.8468845,5.9048801,5.7759987,6.2630627,6.434378,5.8080403,5.7658759,6.0684538,5.9458436,5.4596746,6.015121,5.6758887,5.8167537,5.9481968,5.8088503,5.9109437,5.9974668,5.9068898,5.975973,6.0740919,6.263375,6.0182004,6.2778217,6.3780833,5.760961,6.0237159,6.1360592,5.5108013,5.8328437,6.0814858,6.1732833,5.8749996,5.9158563,6.1446374,6.170061,6.0988006,6.0081713,5.9781187,6.0159831,6.04407,6.012732,6.1453915,6.1351172,6.1451357,5.8325761,5.8802235,5.7369959,5.8391261,6.2685937,6.2567593,6.1992787,5.8655675,5.6623093,5.6288559,6.0333855,6.222328,5.8863727
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+OE33_OESOPHAGUS,ACH-000383,5.702115,6.3976772,5.6521837,5.6178885,6.0813065,5.7141263,5.8144577,6.2197528,5.8198739,6.0930725,6.0993524,5.9466636,6.3687706,5.9249793,5.7928351,6.3159681,6.0898154,6.0838138,5.8849321,6.1257923,5.914848,6.0623848,6.0458111,6.0819784,6.0185826,5.8209703,4.8296154,5.7848477,6.297339,6.0886864,5.6915338,6.0986216,6.1649886,6.0841584,5.7413351,5.7711349,6.2969338,6.6207665,5.7985989,5.8521504,6.2418544,6.2438921,5.9319165,5.9935307,6.0184024,4.6721517,5.6614157,6.1635025,5.9367873,5.9110534,6.4539187,6.6571393,5.6944617,6.2992984,5.6873478,6.4193563,5.8232939,6.0952407,5.6973964,6.0276454,5.65695,5.6050922,5.8183872,5.8839763,5.8687039,6.1880381,5.799295,5.6147965,5.8631874,5.7427337,5.6934975,5.7675106,5.7639839,5.6237046,5.670424,5.5786448,6.0146532,6.2314605,5.8075144,5.6522573,5.7836039,5.8625467,5.8173056,6.2486985,5.8069177,5.8451164,6.1663154,5.7974063,5.9013221,5.9096595,6.2990896,5.8680269,5.7026524,5.9950461,5.696543,5.9370181,5.9688108,5.8554351,5.7151915,5.1035128,4.9051582,6.1067357,6.0616415,5.9690881,5.6843157,5.9125361,5.9995895,5.9794355,6.0954522,6.6164504,5.8850524,5.7868749,6.0075765,6.1339221,5.7541439,4.2639108,6.0422948,6.0719584,5.9018395,5.7994452,5.7095244,5.7153897,5.7484174,6.3070706,5.9467594,6.3855967,5.5865013,6.3549342,6.7583365,6.6269981,6.373503,7.034311,5.9192766,5.9642087,6.0364842,5.9157842,5.7397837,5.7580761,5.5219326,5.8284074,5.7045545,5.7155173,5.8935199,5.9485368,5.7306429,5.4068992,5.4140088,5.8912695,5.7319796,5.7859461,6.3779897,5.8591858,5.8683837,6.1237965,6.22088,6.0146011,5.7879774,5.9666675,5.8041023,5.6995228,5.8840297,5.8111715,5.2727176,5.5465078,5.812568,5.7548974,5.3424062,5.853474,5.6315472,5.883654,5.911445,5.8280249,5.7848242,5.7986917,5.9507398,5.901238,6.1346107,5.8978522,6.0054113,6.1661328,5.9743305,5.5603912,5.781772,5.6809696,5.9031224,5.7386956,5.7476855,5.8817261,5.7925953,5.7288016,5.648228,5.6160657,6.4205693,6.1466567,5.8427139,6.5070928,6.3194984,5.9853548,5.7688088,6.3795142,6.1934188,5.9173195,5.7591903,6.0172507,6.0862786,6.2022036,6.0842982,5.9610311,5.6070686,5.7306159,5.7401573,5.8984441,6.1142786,6.1687693,6.0875316,5.5802369,5.5816115,5.5210201,5.7072948,5.7699711,5.8456869,6.0262528,5.6618782,5.2747221,5.400903
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+SNU182_LIVER,ACH-000483,5.7423468,5.7827714,5.4542794,6.0194757,5.8363485,5.4812983,5.8769563,5.9243248,5.6613099,5.89298,5.9185062,5.7181954,5.6280468,5.7808287,5.8812231,5.8565777,5.730337,5.9346847,6.0272284,6.010308,5.8733805,5.6928358,5.6110704,5.5418107,5.7058676,5.7334989,6.7506999,5.9706235,6.1366657,5.8710185,5.8969011,6.023936,5.6768519,5.5805147,6.0520444,5.3864488,6.0628372,5.853434,5.948803,5.8971778,5.7639319,5.8544181,5.4984049,6.0045478,5.9346808,5.8970536,6.4684606,5.9402539,5.7903345,5.8839763,6.3099081,5.0078292,5.9828814,5.6049258,5.8471789,5.6389677,5.7551038,5.8877381,5.7799345,5.6997966,6.0349644,5.7481506,5.9039639,6.417086,6.0770687,6.0235132,5.999971,5.8462283,6.1051963,5.940559,5.9037728,5.9213286,5.9127033,5.8580061,5.7659247,5.9059926,6.0137761,5.9064106,6.4205241,6.0575061,5.5306112,5.6181651,5.8641064,6.4027328,6.0873731,5.9871535,5.7137078,5.8186877,5.6833201,6.0553245,6.276957,5.9084383,5.9364797,6.0484946,5.6172987,5.823554,5.5045089,5.8312429,6.0551024,5.8760586,5.9833161,5.5801332,5.8092827,5.6627093,5.9265073,6.1229215,6.0351064,6.1248107,5.8522349,5.2877667,4.7622511,5.8780579,5.7525498,5.1642343,5.8072286,7.2212809,5.9718018,5.8392899,5.8476418,6.0571158,6.0972762,5.8585029,6.1629765,6.4390281,5.5848253,6.5248203,6.3422102,6.3715998,6.3377438,6.1592175,6.3080534,6.227131,6.0435547,5.4801245,5.788174,5.9041405,6.2290044,6.0431387,6.1080788,6.2869025,6.1823523,6.2356218,6.0979528,6.1377712,6.2938534,6.5820139,6.3060802,6.0131536,6.2634035,6.7609199,6.084946,5.9011516,5.9148614,6.0129742,5.9132251,5.9516386,5.8319978,5.950862,6.0050966,5.9550369,5.8363096,5.6330752,6.1726576,6.1445207,5.9398373,5.4752009,5.7825485,5.7996826,5.7805708,5.6695032,6.1265834,6.0567628,5.9338435,5.8571375,5.8147123,5.4970479,5.2839855,6.0902287,5.9924519,5.2167942,5.4444571,5.8705675,5.9246195,5.8911276,5.9332553,5.988231,5.9105556,5.7421625,6.1169812,5.9651427,6.0225469,6.1270519,5.6409904,5.4185624,5.7655473,5.6019735,5.4696162,5.4140488,5.8429542,5.6327173,5.5379978,5.4961434,5.5853542,5.678126,5.5635848,5.5851897,5.5584943,5.2406474,5.7694094,5.7877328,5.7602986,5.5574946,5.429028,5.0814322,5.2825123,6.0409865,5.8908321,5.747059,5.6292163,5.4275038,5.2490926,5.3470254,6.0274726,5.7241946,5.6295693
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+HH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE,ACH-000061,5.5773232,5.7338814,5.4341817,5.8420741,5.4556727,6.0713626,5.9538988,5.6613194,6.5553649,5.5308518,5.4438696,6.0665411,6.4139177,5.484084,5.842046,6.0838257,5.9991619,5.6847526,5.3107344,6.1001148,5.6754079,6.1338053,5.9697366,6.0742838,6.0515816,5.2083946,6.1819458,6.1712456,5.6602195,5.6659647,5.1564506,5.9957555,5.7346929,5.8860153,6.2326225,5.3491752,6.0553441,5.3504047,5.7247214,5.3367681,5.5695601,6.0212891,6.4431183,5.9478451,5.1111911,5.6089706,5.0990411,5.0078841,6.0700695,5.3609267,5.2542117,4.088188,6.1359286,6.2233173,6.2164745,5.645009,5.3674455,5.8529615,5.7352943,5.1294329,5.6424177,5.47471,5.1457726,6.0142577,5.8907532,5.7533575,5.6134102,5.2285367,5.7311758,5.2304394,5.2947755,5.2391449,5.2250969,5.2339696,5.1519527,5.2898484,5.9127779,5.9124065,5.7837317,5.7700731,5.9084705,5.8451083,5.5602963,6.0271534,6.2254045,5.6266426,5.4954813,5.413907,5.2639073,5.2507051,5.6543649,4.7488938,6.3988445,5.3235751,5.4535371,5.6460428,5.2776097,5.4174955,5.838851,6.7565686,5.9798497,5.2725271,5.2614907,5.4485092,6.008325,5.4826107,5.4545169,5.0614611,5.4645416,5.1814818,6.1149061,5.9794963,6.2536656,5.041309,5.1832517,4.5638702,5.5671054,6.0328079,5.3702314,5.5671475,5.7787335,5.8153369,5.478122,6.4174923,5.3830253,5.9063091,5.5927282,6.255292,6.5319381,6.7745183,6.3311299,6.1603772,6.3621576,5.7984595,5.6317249,5.61568,5.9719852,5.8784866,5.7532672,6.1998548,5.4028911,5.7313441,5.4006378,6.0460245,5.574087,6.3303792,6.0092453,5.9610463,6.290144,6.3486414,5.7525533,5.9512747,6.5427869,5.934627,5.5085761,5.8569599,6.1945735,6.1814997,5.9616511,6.0871623,6.0297649,6.021107,6.2235052,6.2674499,6.2277254,6.3969523,6.0539596,5.9204431,5.7868215,6.4329773,6.2153761,6.2498981,5.8839763,6.0019367,6.0355553,6.3860461,6.3381439,6.7562313,6.2114676,5.5723652,6.1303814,5.7642538,5.1915616,5.2005767,5.231209,5.0050207,5.1291855,5.4326369,5.2189043,5.1347723,5.3995044,5.4794695,6.1424223,6.4588227,6.389045,5.9034567,6.1356701,6.4495691,6.5316566,5.8502888,6.0838749,6.4507832,6.3821619,6.1731378,5.8884394,5.8065332,6.2282297,6.1678772,6.0728414,6.4204374,6.0267461,6.1470581,6.0215218,6.2620784,6.0507483,6.1801796,6.2207778,6.2782303,6.2212322,6.2280519,6.2560792,6.4917878,6.4740652,6.285917,6.4697688
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+MESSA_SOFT_TISSUE,ACH-000449,6.5960396,6.4028606,6.53427,6.2357237,6.1591645,6.0526395,5.7919388,6.4951626,6.1764353,6.2017948,6.31311,6.4964135,6.4892056,5.5451536,6.2258037,6.8809777,6.2929701,6.2455498,5.7354146,5.9213634,5.8245243,6.5250935,6.4098132,6.7762376,6.1588345,5.687059,5.3606791,5.6548291,5.7081811,5.9833551,5.7502325,5.8715044,6.032857,6.6170853,5.7988607,5.9363472,6.4670557,6.1304873,5.7492037,5.5713243,5.8686846,6.0814356,6.3691073,6.3155417,6.0049743,5.6261135,5.2577056,5.9788879,6.211759,6.2514045,4.0571333,5.9634235,5.6775968,5.6525728,5.9208454,6.2437998,6.3875435,5.9743342,6.6933342,5.9669398,5.5283352,5.5452452,5.7213803,5.5315118,5.971972,6.6155529,5.5922964,5.5034425,5.3081673,5.5098055,5.4641823,5.4318054,5.4127115,5.8380382,5.5537905,5.3639982,6.2925053,7.0435197,5.5563376,6.0734045,6.1826121,5.6617338,5.8972789,6.5956068,5.8670094,5.6470522,5.628522,5.9232351,5.8439199,5.5856261,5.8141195,5.435132,6.3028807,5.4453817,5.2440783,4.6570252,5.2749499,5.776994,5.7443936,5.6200877,4.2851763,5.6284344,5.5652134,5.7172043,5.7485789,5.7631471,5.711012,6.4459645,5.8839763,6.1638596,6.4544692,6.0241391,5.4942616,6.6575596,5.6202354,3.6388918,5.4882729,6.2045394,6.5205776,5.1388422,5.3890006,5.2715403,5.3765633,5.4731473,5.1382558,5.3077055,5.5046158,4.976402,4.7501094,4.6246306,4.8474635,4.7926938,5.4996916,5.8957379,6.4353619,5.519129,5.5415451,5.7913532,5.3737414,5.8208808,5.64714,5.2957864,5.68814,5.3646123,5.3994731,5.6016675,5.721116,5.5757498,5.5074636,5.1836594,6.5154833,5.9150736,5.5198938,6.2832635,6.3615326,6.0356808,5.7820189,6.0181273,5.8356685,6.0025698,5.9086791,5.792918,5.7961592,5.8620547,5.8478521,6.0720284,6.0517168,5.9404451,5.9914681,5.8344882,5.8750305,6.0993803,5.9512396,5.9991813,6.0054979,5.941153,5.7482855,5.3354763,6.0260735,6.1410101,5.8954906,6.2762514,6.2393233,5.8879057,5.9742709,6.1103271,6.123953,6.5125655,6.1546326,5.9136261,6.6822378,6.2490498,6.37546,6.2700788,5.8106727,6.3956817,6.3954319,6.0180425,5.7030122,6.4703411,6.2633495,6.0413496,5.4344201,6.2381883,6.3995316,6.2776594,6.1744791,5.7543543,5.746143,5.8255338,6.2071271,6.420847,6.2496349,5.9401303,5.85336,5.7508554,5.8770414,5.829222,6.3174368,6.3211358,6.2127499,6.1894938,5.6479658,5.75409,6.0878846
+SW1271_LUNG,ACH-000890,6.2983233,5.7416969,5.1084218,5.8839763,5.8876628,5.9384734,5.8936704,6.0570696,5.4808095,5.7969699,5.8684106,5.7858129,5.0229712,6.0093357,5.6619503,5.6916316,6.12325,5.9189062,6.0031535,5.6209142,5.6615036,5.6918822,5.6184451,6.335346,6.0649659,6.4098935,6.1222027,5.8112962,6.1502764,5.5125523,5.9873131,5.41656,5.6063861,5.5399144,5.7428966,6.2864591,6.1010546,5.3861271,6.5490214,5.9603709,6.2979079,5.7983342,5.7220608,5.3674945,5.9393061,6.2885371,5.8167612,5.7886855,5.7128912,6.1625857,4.1917133,5.6902318,5.8952731,5.8474,6.008475,5.8174417,5.6605602,5.6628093,6.8288078,6.4865053,6.9251561,6.94402,6.7513183,5.9258447,5.552696,6.7298052,6.2139322,7.1910627,6.5938142,6.5205377,6.6549219,6.3732204,6.5514279,6.8307125,7.0352758,6.497446,5.4365785,4.9132422,5.7688301,5.8994255,6.1059506,5.9547828,6.6220201,5.2659849,6.0868909,5.8631246,5.8947948,6.1481072,5.8679814,6.0579459,5.8405097,6.0275161,5.7263113,6.1160131,6.7048224,5.8675581,5.9848972,5.6881128,5.9733822,6.510513,6.1323885,5.4621374,5.8371294,5.9973486,6.0919249,5.9516314,6.2490324,5.4134735,5.9053134,5.5328032,5.4508432,5.878368,6.4327411,6.4878704,5.8547924,7.2306746,5.5902452,5.5420884,5.8544025,5.8091406,5.9785036,5.8134809,5.9153867,6.0190675,5.6569914,6.0503075,5.9044452,5.9868902,6.0166698,5.8539074,6.0060564,6.0333268,5.7520983,6.3571733,5.7788671,6.0354557,5.7494104,5.8085585,5.6301704,6.0291093,5.7305616,5.8853437,6.0169602,5.8528495,6.1337128,5.8078212,5.9488955,5.8106549,5.9330344,5.760714,5.2294737,5.5009581,6.2316235,5.763411,5.7904373,5.6238563,5.7787323,5.9564683,6.1122187,5.9063141,5.606207,5.7774199,6.2110812,6.2547401,6.1005088,5.8124684,6.0834214,5.8070701,5.895008,5.786973,5.7628886,5.8029771,5.8706378,5.8232562,5.9105349,5.709671,5.7079243,4.693887,5.425612,5.7782234,5.6745392,5.9798377,6.0407644,6.1240157,6.0824955,6.0780651,5.9147295,5.8722811,6.0426445,6.1199713,5.9672452,6.0436473,5.8560435,5.4320827,5.7021253,5.5621666,5.3822062,5.3293093,5.7016127,5.4815776,5.2850256,5.6318967,5.768662,5.8651328,5.5191506,5.1666496,5.5310145,5.8023304,6.0724922,6.042098,6.0823801,5.7172186,5.389623,5.5486947,5.5736023,6.0840675,6.2733637,6.280822,6.2611749,5.6146022,5.5970763,5.7260356,6.3940144,6.4335468,6.2828411
+NCIH1792_LUNG,ACH-000496,6.1024784,6.0021785,5.6668142,5.6541119,5.9097164,5.953206,5.9273075,5.9632438,5.9190001,5.9122782,5.9291511,5.7517418,5.7611297,5.8371143,5.9604192,6.3607209,5.868951,5.7435829,6.0934238,5.9944289,6.1148569,6.1768779,6.2438138,5.9800909,5.7826648,6.0884969,5.8484751,5.7701973,6.2362242,5.8572829,5.6524938,5.9112261,5.9146125,6.2061141,5.9415447,5.9770478,6.0080422,6.1884908,5.9028013,5.9791958,5.4404775,5.9228228,6.1056172,5.9623303,5.8193461,5.676981,5.9191831,6.1472978,5.5000997,6.1448259,6.2936547,6.3050117,5.9428972,5.8289015,5.8897244,5.6632878,5.9154508,5.773751,5.709718,5.2707444,6.1162387,5.8824,5.9519271,6.0024466,5.7908853,6.0011756,6.0299916,5.7454391,6.0729417,6.0276557,6.0138581,5.9192077,5.9084266,5.943068,5.9234876,5.9052239,5.8516573,6.3758661,6.0936164,6.1617748,6.0398428,5.9440209,5.909433,5.2374136,5.8652761,5.9117172,6.1764662,5.9123785,5.8358013,5.8958345,6.39894,5.6096428,6.1448174,6.0425013,6.6904273,5.9478198,5.8214633,5.8385497,5.9864865,6.5769001,6.1750807,6.0118632,5.8542218,5.7917377,5.2580876,6.0044097,6.0041315,5.7110056,6.0197456,5.7292801,5.9220581,5.8984396,5.4414795,6.3511383,6.0109515,7.3456906,5.6442076,5.819453,5.6420358,5.7621671,5.8427558,5.7598478,5.9611045,5.8185905,5.5788986,5.8839763,6.0707841,5.8089855,5.6475238,5.6278243,5.6622887,5.6897586,5.8485768,5.4583792,6.0482519,5.9604874,5.1814631,5.7541304,5.6280278,5.8854948,5.6693181,5.8679104,5.9570675,5.8601001,5.7387278,5.7758231,5.7745617,5.9164621,5.966317,5.9304805,5.3554456,5.6095972,5.8733719,5.6115744,5.8592616,5.623146,5.853454,5.7914491,5.6375096,5.8167098,5.8804453,6.0219302,5.8516003,5.7784806,5.8290549,5.8582855,5.9794533,5.8580729,5.8185362,5.8301453,5.7454281,5.8721447,5.8335435,5.8494476,5.7449636,5.9317147,6.0486122,6.4634874,5.7364508,5.6549781,6.0616486,5.7902653,5.6804914,5.6736205,5.898682,5.7442943,5.534216,5.1143984,5.7413329,5.7632003,5.6916444,5.5223794,6.3495405,6.0231332,5.7982732,5.9602852,5.7968852,5.9338647,6.0538303,5.7030247,5.859436,5.9456236,6.341374,5.6793604,5.7784496,5.8542017,5.9416746,6.1055674,5.6621832,5.4920343,5.6327853,5.8976795,6.0129746,6.2248401,6.6885142,6.079744,5.8533128,5.7525263,5.6717716,5.7049032,5.9274582,6.4303329,5.6729245,6.0077269,5.7101738
+GCT_SOFT_TISSUE,ACH-000835,5.7979874,5.8682164,5.4804281,6.2997851,5.409834,6.1241793,5.9884265,5.7525547,5.5776294,5.3392815,5.4860452,5.1892502,5.3680932,6.1768331,5.9868352,6.3724195,5.9351948,5.788377,6.1753297,5.9631219,5.8261421,5.8485617,5.6884994,5.5526861,6.486022,5.9543936,6.6303858,6.2516018,5.8359099,5.9143439,5.8253446,5.8264439,5.6202972,5.4033201,6.0191094,5.5739647,5.8689762,6.0583951,6.1270584,5.8227443,5.7196795,6.247711,5.5098114,5.5586376,6.1529768,6.0278197,5.8343727,6.1599189,6.8901853,6.5423592,5.2714723,5.7881489,5.8276694,5.4667876,5.9883906,5.8129731,5.6743484,6.1228903,6.1762622,5.9082905,6.2768731,5.9012496,5.9369576,5.7367112,5.9187534,6.1110851,6.0283905,5.9604167,5.8289086,6.0639701,6.0212315,5.9298969,5.8515151,6.0164512,5.7266519,5.8116385,6.0668406,6.5399194,6.0074313,6.1989069,5.8329317,5.9155273,5.6597601,6.1224487,5.808365,5.9495623,5.4661459,5.8894265,5.8824197,6.0214514,6.5705065,6.0337763,5.6123222,6.1149396,5.9973752,5.2511824,5.6446238,5.8199245,6.1630132,5.9209921,6.3896716,5.9159836,5.9322106,5.5788041,6.0687655,6.4110264,6.5279526,6.1567053,6.1102385,6.5835258,5.3618227,5.6918353,6.0885309,5.6047767,5.8771044,7.2988088,5.4872366,5.715501,6.6439424,5.6348451,5.5743338,5.5702383,5.6856496,6.2683296,5.1502857,5.7384219,5.9599078,5.6221669,5.6559746,5.9663033,5.943418,5.8071853,5.974281,5.9814728,6.122205,5.8627035,5.9918261,5.8683694,5.9319672,6.6682799,5.8683262,6.1819553,5.917796,6.1248627,6.2132427,5.8697864,6.0984413,5.6365121,5.6477679,6.2007971,5.5795502,5.688263,5.9900033,5.763095,5.6694829,5.7212197,5.8839763,5.9841876,6.0469499,5.742311,5.6558595,5.6401578,6.1887746,6.1796428,5.9969253,5.372568,5.99169,5.8825297,5.8693753,5.6991859,6.0593643,5.9463895,5.7858521,5.8700122,5.608237,5.3748612,5.1017073,5.5963041,5.6395177,5.7399887,5.7698838,5.8917355,6.0538592,6.0208932,6.0056127,6.1323061,6.0697119,5.9754504,6.10883,6.0578726,5.9631452,5.9671734,5.8774419,5.4994471,5.7922632,5.6801894,5.653647,5.3506556,5.6628391,5.5181708,5.722625,5.70342,5.6927716,6.1467349,5.9592848,5.7883534,5.9200682,5.7926525,6.1661146,5.9003733,5.5489342,6.0394973,5.7393946,5.6482584,5.6063503,6.0675146,5.7962414,6.3777161,6.1364959,5.8764358,5.5028278,5.5885904,5.7544838,6.2938382,6.3239149
+SKBR3_BREAST,ACH-000017,5.9930355,5.9611823,6.2394435,5.9776763,5.8878468,5.7043758,5.9475389,5.824698,5.5638499,5.7441205,5.7101585,5.7938727,5.0963522,6.5205911,5.4538162,5.8810374,6.1333462,6.0045896,6.2129365,5.752199,5.6417614,5.8613217,5.2444303,6.1431233,6.0413674,6.1559198,6.4644747,6.2041172,5.5638942,5.9222056,6.4046757,5.7570693,5.7246074,6.4049601,5.8413243,5.8031497,6.1822685,6.1858142,5.8731825,6.0125985,6.3358404,6.6409911,6.2880435,5.7271923,6.2699656,6.227791,6.1598447,6.3289288,6.2792943,6.6988883,4.3731,6.4134474,6.1121121,6.8004948,5.589908,5.9944636,5.8035185,5.9409429,6.2714583,6.2300282,6.3335405,5.9426572,6.0967123,5.9913141,5.5643397,6.2854082,5.9801993,6.0990464,5.8822834,6.1822351,6.0195682,5.9551579,5.8911677,6.122618,5.9775052,5.8433293,6.0249586,6.4913685,5.8776284,5.9677395,5.1824458,5.8536064,6.3878924,5.2817933,5.8132535,6.0735134,5.4142785,6.0837259,6.1193382,6.064768,6.1937296,6.1130126,5.6746364,6.1304083,5.7329492,5.3551371,5.9747984,5.8380246,6.1624523,5.3401038,4.8127582,5.7456066,6.0347534,6.1431601,5.7898082,6.060414,6.6355691,5.4721402,6.2113143,6.1085623,5.6461637,5.55215,5.260207,6.2163678,6.0489299,4.3597316,5.6466241,5.1946141,6.6152429,5.8848263,6.0484949,5.6582846,6.039244,6.5247423,6.3659084,6.1843843,6.0522729,7.3174194,7.880633,7.8642977,7.6618497,7.4501235,6.64804,5.6914295,5.2313537,6.0337392,6.1822473,5.9362928,6.0579164,5.9416122,5.7949446,6.1241788,5.8576946,6.0799355,5.8403902,5.8793331,5.5210438,5.6104009,5.6685319,5.899632,5.5212665,5.7340958,5.6253505,5.69702,5.5690552,5.6375254,5.8254304,5.6323165,5.6943943,5.6754309,5.5159509,5.7505177,5.4389175,5.6514327,5.5732074,5.2429729,5.7843955,5.8542576,5.6782058,5.8781596,5.7714227,5.8820619,5.775502,5.902005,5.4851938,5.6547019,6.243249,5.2945913,5.4826167,5.4430731,5.7316821,5.9168959,5.8360802,5.8839763,6.0528468,5.8759507,5.8361447,5.868104,5.9102314,5.9236698,5.8702368,5.7034914,6.2507627,6.7176896,6.6649238,5.9126029,6.1118884,6.4382046,6.5444679,5.7911136,5.8929145,6.1210592,6.3424415,5.9983224,5.7430264,5.6415853,5.7125942,5.9356168,5.4383385,5.7305383,5.8069425,5.4828315,5.3666018,5.6245608,6.0277527,5.1231846,4.9482943,5.757572,5.702686,5.3654282,5.107086,5.5314461,5.306199,5.2126183,5.4405442
+SNU16_STOMACH,ACH-000581,5.1571133,6.3187617,6.3448286,6.0906245,5.498283,5.7984455,5.6815369,5.6448287,6.5303709,5.5904561,5.4532958,6.5330017,6.0119658,6.2741107,5.9180334,6.0038187,5.5122815,6.1392417,4.8272,5.8453756,5.9913504,6.0510994,6.095564,6.4241308,6.5998713,4.8708512,6.3056615,6.2885591,6.2100784,5.5727668,5.329079,5.7378557,6.0569377,6.0384935,5.8842115,5.8672485,6.5459213,6.3916658,5.1100032,5.4446449,5.34743,5.7328956,7.2082246,6.1428537,5.8171073,5.5564567,6.8227277,4.7357975,5.5420959,4.9867023,5.3003864,6.2344587,5.4728892,6.0966214,5.971,5.6487377,6.0586702,6.0992165,6.250641,6.2181118,5.7136769,5.6250439,5.3768138,5.4097265,5.448698,6.0939322,3.9449192,5.3343488,5.6431055,4.9263786,5.409805,5.4982267,5.5902065,5.4332643,5.642248,5.6290278,5.9285409,6.5795088,5.9686755,5.6726913,6.0577741,5.6002386,5.5975062,6.5174009,5.6101753,5.3234172,6.0197715,5.703787,5.6005357,5.2725402,5.3064623,5.0512118,6.67705,4.8015602,4.7988047,5.7733885,5.4157665,5.6710488,5.3146968,5.4876348,6.0492471,6.2720071,5.4465165,5.3126835,5.836234,4.9313539,6.0813833,5.9799069,5.3057475,5.683943,4.9117903,5.7537972,5.8159932,5.8112348,4.5337331,3.6680575,6.050333,5.7895229,5.7327956,6.0285877,6.2369274,6.3085629,6.019301,6.0105491,6.0949046,6.3936829,6.1231595,6.5410979,7.0171946,7.1474707,6.8783114,6.6221504,5.8867952,6.2989245,6.1287698,5.3504059,5.9978517,5.8812785,6.0950828,5.9051761,5.8422248,5.8719881,5.8460738,5.9662365,5.4107036,6.1945045,6.1263494,6.7626839,6.4019941,6.0964969,5.9242036,6.0170034,6.2622265,5.6307251,5.3301564,5.9679997,6.0386357,5.848244,5.5972188,5.7366597,5.9779805,6.0788329,5.3084948,5.401027,5.6223458,5.616235,5.8706504,6.0075307,5.8418807,6.1761871,5.8194245,5.9098706,5.8306641,5.5493114,6.0244924,5.5437014,5.7892771,6.4588682,6.4412972,5.9208779,6.2306355,5.4836056,5.0949724,5.1737601,5.4759968,4.6522654,4.67883,5.2656166,5.0308428,4.9454497,5.0759818,5.1106392,6.4979736,7.0184621,6.6858377,6.3191546,6.9037295,7.1417573,6.9624738,6.5332972,6.902209,7.1605866,6.8334137,5.9396086,5.9994278,6.486321,6.9548796,6.8690041,5.9113602,6.2077946,6.0377803,5.8839763,6.6900998,6.8926976,6.804566,5.7685091,5.9010519,5.705338,5.6362347,5.6709993,6.0703235,6.6171615,5.5040871,5.5205872,5.9685022
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+BICR31_UPPER_AERODIGESTIVE_TRACT,ACH-000228,6.0503,5.7587004,5.3944643,6.2185061,5.796051,5.7452354,6.0032317,5.9962917,5.5476499,5.8997614,5.8205206,5.7288445,6.0445529,5.7521995,5.6735912,6.0914688,5.6884832,5.9076563,6.1196836,5.8596915,6.1853779,6.1575635,5.8941582,5.8426597,5.7585336,6.3431633,5.3139073,6.0904515,6.2752923,6.0750246,6.1787976,5.8617166,5.9970795,5.7929609,5.7306556,5.7874199,5.6378991,6.1709031,5.9835575,6.10204,6.4302464,6.4028958,5.714202,5.8415421,6.2387733,6.1305468,5.5492861,6.2460128,6.1972503,6.0915284,6.3644125,6.1483939,6.0091134,5.4130694,5.8744307,5.6164578,5.9063647,6.0895907,6.2064755,6.0403493,6.1879725,6.4951694,6.2219377,5.8755278,5.9192446,5.028765,6.1544198,6.0543557,5.5634488,6.4964935,6.5056378,6.15528,6.1903898,6.431162,6.3662623,6.2414717,5.4754162,5.3921173,6.0381616,6.1581092,5.4161525,5.7937478,5.5039763,6.1727525,5.9674137,6.1111598,6.3046452,6.0346539,6.2248267,6.1628639,6.3169062,6.1363537,5.7741722,6.160993,6.0201899,6.2991583,6.4879248,5.9639548,6.0933629,6.2904959,5.1594712,5.7298503,6.0253259,6.2326178,5.8944775,6.2229304,5.9525806,4.8946298,6.1944539,5.4973928,4.5538746,5.8289798,5.403883,6.2618518,6.2705092,7.0739309,5.928396,5.983228,6.1224431,5.9488853,6.1334556,5.9810249,5.945442,6.0381318,5.7627054,6.1088651,6.1720985,5.9086571,5.8839763,6.2178653,6.180578,6.4172951,6.1205887,6.0152545,5.7275038,6.1243022,5.5915161,5.5507836,5.6437003,5.6367875,5.6198579,5.9728628,5.595212,5.8841237,5.688631,5.5839229,5.4446646,5.8258683,5.510545,5.6835747,5.4117528,5.5526486,5.8380127,5.505943,5.7708636,5.651215,5.7734684,5.7986556,5.8332158,5.8302852,5.7627621,5.9766882,5.8018546,5.8619364,5.9492208,5.7821275,5.8290749,5.8635993,5.8794631,5.8953556,5.7483068,5.8908199,5.917699,5.8055848,5.7449425,5.87532,6.147035,4.9700482,5.3295201,5.6370093,5.6739616,6.0979594,6.0309065,6.0496854,6.1393183,6.1258442,5.961504,6.0701762,6.1422234,6.217733,6.2259916,6.2062131,5.5476124,5.4571605,5.7388733,5.4804534,5.3361754,5.5192963,5.6127034,5.4208805,5.5637166,5.6639105,5.6793319,5.7124533,5.7452303,5.5498543,5.5046636,5.5992694,5.9493804,5.8032237,5.8054993,5.7396495,5.3991102,5.5770485,5.7525838,5.7572384,5.7734982,5.8062124,5.7859712,5.5980263,5.4008277,5.6358669,5.577647,5.8565749,5.8397392
+COV362_OVARY,ACH-000278,5.7149653,5.0300495,6.1042009,6.2278942,5.5013086,6.0713129,5.9174865,5.8192669,5.764489,5.5413868,5.3961949,5.821424,6.2411373,5.466894,5.6604042,6.0449995,5.8604846,5.9446304,6.1669967,5.7896407,5.8241086,6.1852807,5.8736068,5.4030083,5.552448,6.231453,5.1641371,5.8657069,5.8089569,6.1342754,6.3463348,5.8078909,5.8933934,5.7312595,5.6756816,5.912037,5.0110977,5.6866393,6.0431792,6.1543907,6.2479946,5.8635076,5.9783156,6.0030284,5.9370502,6.1133469,5.4423312,5.9200294,6.0878473,5.8853667,6.4201694,5.26417,5.89051,5.8572251,5.7516807,5.8839763,5.5164422,6.1166355,5.8215949,5.9962346,6.3839213,6.4662183,6.2206414,5.4944749,5.9928451,5.2431507,6.1162208,6.1037886,5.8465001,6.5897779,6.4762259,6.143509,6.1977218,6.4096102,6.3339361,6.34021,5.7273457,5.0678297,5.8749445,5.8556911,5.3244842,5.6932151,5.77638,6.0529155,5.9046242,5.9215347,5.6363325,5.9142532,6.0986899,6.0083076,5.983926,5.9947974,5.4651905,5.9957026,5.3028808,6.3750757,6.5720858,5.8567155,6.0511087,6.5887725,6.3657609,5.556021,5.7910598,6.1044049,5.8279321,6.4259905,6.411745,6.0796858,5.9795506,6.0017363,5.457389,5.9403867,5.9282242,6.1029587,6.2737116,6.6556221,5.667665,5.76044,6.0280639,5.4722572,5.2982342,5.5866015,5.566847,5.1473296,5.3883266,5.6770009,5.9467691,5.4816332,5.1474655,5.5084041,5.9961303,5.6227667,5.8608349,5.8510906,5.4977397,5.8392957,5.3968951,5.3618289,5.4524532,5.8401183,5.6106531,5.8126608,5.6185081,5.7641573,5.9494446,5.6810568,5.5601808,5.5507637,5.459065,5.5227679,5.3340671,5.5424283,5.9210887,5.5597851,5.7794357,5.6479648,5.809375,6.0452952,5.8582233,5.8479996,5.7585777,5.9479521,5.9387036,5.9351976,5.8855583,5.6981083,5.9212694,5.846434,5.8842016,5.9022128,5.8195017,6.0373444,5.9441702,5.816762,5.7235214,5.9726038,6.2573512,5.538994,5.460904,5.4934081,5.6380358,5.8648672,5.8940836,6.0049903,6.0215419,5.8848285,5.8622105,6.0693623,5.9363086,5.9879761,5.7818365,5.8806921,5.9768348,5.8517173,5.9393347,6.1336731,5.6006271,5.7400079,5.8258487,5.6338885,5.5810161,5.8120995,6.0566242,6.0725962,5.8852043,5.7635797,5.7653279,6.0652925,6.2596482,6.2131383,6.1741831,6.0081523,5.7217004,5.957403,6.1943077,6.0586004,6.4880931,6.2954763,6.2400387,6.2381077,5.8481066,5.9985381,6.4759965,6.6314381,6.4827586
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+HT55_LARGE_INTESTINE,ACH-000926,5.4618301,6.1058425,5.3430676,5.8679124,5.8463352,5.6360198,5.5855955,5.6565406,5.6177981,6.1454781,5.7784899,5.9021648,5.2325271,4.9379827,5.7864861,5.6195056,6.6467455,6.2005912,5.7067705,5.584761,5.8938918,5.776041,5.8738717,5.6501654,5.0693485,5.7278275,4.9298819,5.3791284,5.8128377,5.7353518,5.6673393,5.5884567,5.8951598,6.4459472,5.5653396,6.1641601,5.9509891,5.7493581,5.8893441,5.5393568,5.3133688,6.0678946,5.6543307,5.5048359,6.0836241,6.1766607,5.4227042,6.0017502,5.4998061,6.2031421,4.8558258,6.2372706,5.9156397,5.7942842,5.8246193,5.5769654,6.0421069,5.7370556,5.9227916,6.3351034,5.6186771,6.0729742,5.7782453,6.417993,5.9212998,5.7329812,6.3053003,6.079251,5.8839763,6.1658785,6.202584,5.9107114,5.94624,6.1669175,6.0360587,6.1498455,6.0001175,5.545398,5.8220115,5.684107,6.3844037,6.5354705,5.8660243,5.9427729,5.7787735,6.0241994,6.6356526,5.9777662,6.1684945,6.043311,5.7837984,6.1468865,6.039239,6.0537917,5.647376,6.1326454,6.1072046,5.9321497,5.2764404,6.6191223,5.5944032,5.9556926,6.0656509,6.1530928,5.9977935,5.8494312,5.8197999,6.316511,6.0152704,6.8343814,5.3661758,6.1818803,5.9004477,5.5260329,6.2562435,4.9138186,6.1323507,5.9876278,5.5635212,6.3618936,5.8828636,5.7295868,5.8193786,6.3624975,5.4698522,5.6570123,6.0379191,5.7574498,5.3935609,5.7015569,5.8048457,5.5828306,5.4537655,6.0513639,6.3003875,6.0827949,5.6502672,5.8989295,5.8532465,5.7464343,6.0574365,5.69975,6.0698349,5.6700057,5.547755,5.8556186,6.0257699,6.0781631,5.623787,5.1445289,6.2035047,5.9639403,5.7738225,5.8039849,5.8726605,6.1074723,5.940682,5.7907652,5.7545136,6.0164615,6.0895361,5.9859241,5.6642462,5.6523847,5.7950619,5.7510686,5.2807532,6.1104556,6.0912703,6.2373712,5.4345253,5.706424,5.6613474,5.8852224,6.205659,5.957323,6.1701422,6.0826517,5.4088443,5.8439907,5.6248813,5.6822217,5.7168533,5.8435687,5.6573119,5.6894529,5.6717528,5.9067204,5.5593077,5.6701683,5.334296,5.4143548,5.888113,5.8699763,5.6534146,6.1989519,6.3058106,5.8768994,5.45432,6.3134197,6.3175277,5.9388352,5.7333521,5.9504267,6.0003648,6.4496495,6.2879557,6.1906396,6.2419726,5.7279092,5.6994257,6.1122465,6.5598963,6.626807,6.1538186,5.7065987,6.2055669,5.8232903,5.8841973,6.0894462,6.4601476,6.462613,6.3381294,6.4396523,6.1421016
+OAW42_OVARY,ACH-000704,5.7239713,6.3166117,5.7701956,5.766469,6.1952778,5.6148818,5.629189,6.2308433,5.6192839,5.9146322,5.8990924,5.9107521,5.8699491,6.0452203,5.7755853,6.1019054,5.9396234,5.9580094,5.9934864,5.8599676,5.8429856,6.1095003,5.950195,5.502059,5.780751,5.6173724,5.0978574,5.6398741,5.1485709,6.0232672,6.2206147,5.8904645,5.8587771,6.3601346,5.5362113,5.5703359,5.8239072,5.969704,6.4993515,5.7231037,6.065715,6.0474297,5.8300424,5.831686,5.9073594,5.764297,6.1388713,5.8931226,6.3730488,5.5806162,5.9519723,5.9401545,5.7028286,5.6264029,5.6845566,5.4541686,5.5410165,6.1777243,6.2610951,6.2570782,5.9278439,6.3755467,6.1882502,5.7366232,5.986773,5.0388609,6.3961393,6.0539511,5.5700387,6.356238,6.31624,6.1357209,6.126634,6.3381611,6.2542561,6.2682782,5.9650314,5.0930785,5.5673789,5.8848268,6.1329942,5.7976933,4.7650541,7.1874958,5.8472232,6.1487505,6.266738,5.793535,5.9309922,5.857184,5.7700341,5.9863898,6.1145341,5.7812205,5.9162788,6.1875078,6.3202774,5.8918525,5.8332629,4.8472125,4.4514618,6.1663835,5.8809712,5.6208855,5.5948959,5.6710554,5.6950578,6.4172261,5.9840398,5.4700776,5.9332852,6.4217204,4.987243,5.3452012,6.2436027,7.3240673,6.3102468,6.179589,6.0940212,6.4416882,6.3164064,6.2524994,6.2545434,5.5968511,5.7164315,6.1936701,5.9046388,5.9982366,6.0562654,6.0191823,5.5717582,6.0275315,5.4526081,6.1342513,6.4815248,5.8338756,5.7375352,5.7593057,5.3540882,5.649382,5.485308,5.3095995,5.5384454,5.3645673,5.6412884,5.5526487,5.5085119,5.5136169,5.6405312,5.1718399,6.132936,5.8090512,5.9487832,5.8984475,5.864556,5.8503221,5.7379696,5.8891806,5.6572954,5.6307625,5.7898695,5.5039433,5.6180345,5.6228391,5.6397853,5.8314113,5.4646307,5.9803028,5.6378782,5.8169494,5.5071603,6.1730188,6.5036776,5.7384349,5.80759,6.0522545,6.2864165,6.6522463,6.4722274,6.2463727,6.1836689,5.642893,5.5426295,5.721839,5.4577623,5.5346989,5.6652432,5.6584242,5.534758,5.5634328,5.4272355,5.6580862,6.071761,6.0523364,5.9799161,6.3180816,6.1710633,6.1454187,5.9224999,6.2152185,6.149741,6.0645503,5.8839763,5.7027907,5.9766957,6.0920048,5.9709436,5.9770737,5.7724539,5.5919554,5.7447337,5.9265164,5.9359613,6.0338723,5.9990739,5.3917929,5.8589105,5.6220439,5.5492255,5.922211,6.1324032,6.2697845,5.6517836,5.5021712,5.5065768
+MDST8_LARGE_INTESTINE,ACH-000935,6.1349444,6.2291072,5.6372181,6.1190807,6.0402659,6.6135528,5.4992553,6.8760553,5.7051553,6.083387,6.0926508,5.7671575,6.3692303,5.5799922,5.715184,6.3149692,6.1001098,6.1880637,6.0669306,5.9916966,6.1072004,5.8658168,5.9023117,5.8134044,6.2139567,6.0778975,4.5278443,5.8723425,5.5898403,6.0044043,6.1601321,5.9764038,6.0665267,5.8898106,5.6964235,5.8810337,6.3028761,6.7424537,5.8582388,5.8925484,6.1251795,5.6650422,5.8322642,5.8839763,5.9089946,6.0965745,5.3001962,6.0086455,6.0159599,6.0676011,6.3027977,6.6203262,5.6852278,6.7254989,5.8862959,5.8964925,5.5311387,6.1287055,6.2218294,5.8136615,6.0833897,6.457314,6.1939018,5.6381243,6.0562977,4.5839402,6.2367727,5.832275,5.5406842,6.3226601,6.2994982,6.0172638,6.0165822,6.2754523,6.2123816,6.1320236,5.6838615,5.1851913,5.5578823,6.0569209,5.8206444,5.8827822,6.5432043,6.2429668,5.7767189,5.932527,6.0675374,5.8211688,5.8982699,6.0303258,5.8039382,5.9228385,6.0174728,5.9381035,5.7582331,6.2556871,6.3503399,5.7986985,5.8873943,5.0312334,3.7298156,6.2201676,6.0880296,5.9559183,5.7196766,5.9979788,5.8800206,5.8494982,6.0354471,5.9924633,5.7602548,6.0645114,5.6014629,5.7938482,6.0914979,6.7119342,5.9202897,6.0154739,5.8550763,6.037178,5.9501763,5.8127101,5.878447,5.7361133,5.4795743,5.9846773,6.0364182,5.4075261,5.3630101,5.3010899,5.0676814,5.2919202,5.5576947,5.8840019,6.0642885,6.0204484,5.6977477,6.1254485,6.0650214,6.0290413,5.9570477,6.0421302,5.8568326,6.0038428,5.896049,6.2751177,6.120072,6.3193889,5.8277432,6.2157165,6.0403852,5.8077853,6.1288823,5.782948,5.9296327,5.7897435,5.7375049,5.6580027,5.6384233,5.6611505,5.6681796,5.7661015,5.5906578,5.6755741,5.6386468,5.4279685,5.5980479,6.0154983,5.8839436,5.879274,5.6814855,5.9419748,6.2214356,5.6077561,5.6709716,5.8220764,5.996504,5.1381779,5.6337103,5.5490772,5.7289638,5.7609145,5.9106144,5.9660472,6.0504832,5.9876831,5.8721549,5.9652216,5.9777748,6.0066435,5.8768655,5.9425862,5.7612628,5.6992468,5.9170202,4.9982928,5.5162542,5.792181,6.3546843,5.4436812,5.4547448,5.9469346,6.2295295,5.5440761,5.5868351,5.3601093,5.4725608,5.6952012,5.6727821,5.6702151,5.506487,5.249428,5.0750958,5.2551825,5.5932245,5.876027,5.4486804,5.4343674,5.0415176,5.0641384,4.8843718,5.2239045,5.0256956,4.4793966,5.236515
+OAW28_OVARY,ACH-000116,5.6975258,5.7654683,4.965903,5.6685515,6.0386833,5.5100743,6.098071,5.8916935,5.8910777,6.1273189,6.0155067,6.1782846,6.3860553,6.2387681,5.3989237,5.7779524,5.9630597,6.0283595,6.2558148,5.9460727,5.9140659,5.7358878,5.723745,5.8461148,6.293468,5.5939116,5.7336346,6.1287124,6.365295,5.8163097,6.2831501,5.9203354,5.6479491,6.2490648,5.9111898,6.0408458,5.5755549,5.866126,5.6305612,5.7041531,6.1050975,5.941568,5.9962447,6.0880561,5.7299081,4.1577951,6.8400244,5.8508063,5.8066801,6.1014814,6.1946861,4.9580705,5.8784228,5.6790264,5.9587255,6.0527256,5.8005542,5.8450749,5.8199695,5.9749937,5.9855567,5.8154265,5.9518398,6.0100015,5.8107665,6.1690401,5.9708231,5.7822917,6.1651725,5.9220741,5.8870028,5.9185639,5.9412507,5.8102919,5.8296185,5.8924161,5.780518,6.0109133,6.0538091,5.9808224,5.9441888,6.0558153,5.693314,6.0887533,5.8723975,5.9740793,6.0953659,5.8559354,5.8217731,5.9736359,5.7912486,5.8839763,5.7078221,5.9180948,5.5308177,5.9196528,6.0662681,5.9720367,5.9711584,5.5469303,5.8619732,5.9262734,5.9908541,6.1422357,5.8777497,6.1968822,5.557088,5.6219429,5.9663524,6.1815027,5.4191199,5.7347556,5.913847,5.1852844,5.8407124,3.8338559,5.9088285,5.7680911,5.959704,6.0749804,5.9795902,5.7601622,5.9511919,5.8102363,5.4541843,6.013804,5.9722833,5.6986136,5.4415716,5.5266155,5.7208021,5.0536367,5.7405283,6.01186,5.7942247,5.9130096,5.755219,6.2029122,5.8521968,6.0873759,5.77423,5.7526138,5.735129,5.7597519,5.8258965,5.4706818,5.7169728,5.758112,5.6003647,5.0568701,6.3873842,6.0198473,5.5235487,6.0781745,6.1872915,6.0123083,5.6965314,5.8280771,5.9877755,5.9021336,5.7778284,5.1652887,5.4715434,5.7943229,5.8797816,5.4497079,6.1118172,5.8739016,5.5736496,5.58375,5.8285045,5.685609,5.8874027,6.0619975,5.7381513,5.5332823,5.6142872,6.1467995,6.0539026,6.4043595,5.9553296,5.547515,5.5061725,5.6543843,5.5561052,5.5908985,5.5975763,5.5525565,5.0453664,5.4594518,5.4544712,5.2968439,6.6713666,5.8847952,5.7715022,6.9105985,6.5325849,5.9035845,5.5561789,6.7586273,6.1927904,5.5639014,5.4033779,6.8301197,6.8894046,6.440451,5.8513807,5.4733346,6.2798946,7.0845583,6.3852337,6.596713,6.1604733,5.5217643,5.4319775,5.3247596,6.3368739,6.5765746,6.676023,6.4376065,5.9604359,5.5690756,6.0937158,6.136057,6.6277248
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+SNU899_UPPER_AERODIGESTIVE_TRACT,ACH-000692,5.7188332,6.1844717,5.2400952,5.7812586,6.1624456,5.9349394,5.9498277,5.7947665,5.4627396,6.2665147,6.270567,5.6212352,5.8704248,5.4603287,5.4706099,6.1448447,6.0158357,6.1010295,5.8875297,5.8743033,5.6615917,5.8422075,5.7889284,5.6908445,5.662838,5.8451115,5.2182712,5.8530255,6.1041592,5.8839763,5.8716775,5.9101427,6.0061539,6.2616664,5.8402721,5.6701029,6.0431739,6.2397516,5.7850253,5.7112583,5.5976879,5.7768983,5.4154771,5.823909,5.7445556,5.9213601,5.5641062,5.9306843,5.9187635,6.112056,6.1358641,6.4534156,5.9927913,8.0512748,5.6315117,5.9879125,5.681927,5.8672289,5.8593021,5.6966465,5.691763,5.7204951,5.9233168,6.0155765,5.8146314,6.1739184,6.0912427,5.8293317,6.1710072,5.7695784,5.8117835,5.88522,5.9747002,5.8457923,5.8091501,5.9214999,5.9635843,6.0689212,5.8239842,5.9444918,6.025838,5.8228231,5.8142176,5.7477327,5.8225293,5.9667331,6.4017601,5.9605038,6.0169103,5.9916959,6.5854104,6.0387483,5.9796001,5.9304856,5.7657595,6.0070214,5.8872827,5.90466,5.8015095,5.8773237,5.7716452,5.9946012,6.042326,6.1362733,5.839322,5.9723122,5.6787367,5.3408957,5.899747,6.3766173,5.4285782,5.2644052,5.9238772,5.1287455,5.8643241,7.4579672,5.9943666,5.8028451,6.0817483,5.9313966,6.2049343,6.5993073,6.3177901,6.3807622,6.1225858,6.6225975,6.2460967,6.7482056,6.5969356,6.2132598,6.1662872,5.7717435,5.7163032,6.2156957,6.1899619,5.9605402,6.0269808,6.0697451,6.1639793,6.3355924,6.11116,6.1969723,6.095675,6.1791055,6.0212369,5.9113996,5.9064505,6.2743366,5.5527677,5.4786838,6.098328,5.9711791,5.773063,5.7315106,6.042493,6.0331397,5.9287081,5.8034538,5.7561727,5.7959744,6.0515802,5.9599216,5.6286134,5.604914,5.7655238,5.9293765,5.9230426,6.0132632,6.034697,5.8241984,5.1964669,5.5316438,5.0864021,5.9686312,6.1115238,5.7514899,5.6273946,5.5900395,5.7177599,5.8789607,5.7400831,5.9540591,6.0796816,6.0662226,6.2699141,6.1172369,6.0239065,6.0342,6.1153438,6.2567149,6.1948,6.0688029,5.6852059,5.7386836,5.8449163,5.6139986,5.841818,5.8661182,5.8694797,5.691832,5.8978288,5.8264121,5.8620625,5.7623081,5.5461061,5.7925074,5.7504519,5.7091895,5.6968552,5.8348297,5.311764,5.7975131,5.855989,5.7410081,5.724298,6.0867802,5.477444,5.7554521,5.6095327,5.5875862,5.768567,5.7502236,5.1542106,5.0596366,5.3697435
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+786O_KIDNEY,ACH-000649,5.6542144,6.370851,5.9898268,5.7705223,6.2346027,6.3297374,6.0071991,6.5848669,5.785369,6.0967976,6.3156905,5.7662499,5.2824619,5.5305946,5.6749052,6.613015,5.7853763,5.8457283,5.8470658,6.0295785,5.9147278,6.1591749,6.0370677,5.8880601,5.767266,5.8839763,6.5824525,5.7802901,5.8342691,6.1586594,6.0129512,6.0612467,6.060565,6.2862686,5.8860678,5.89718,6.5075256,6.3640788,6.087791,5.9162823,5.9067996,5.6055754,5.7897017,6.0928239,5.7638712,5.9399335,5.1357271,5.9188042,5.8647355,5.8465781,6.1820833,4.8002755,6.0026409,5.7563714,5.6661743,6.7913029,5.9758289,6.2369018,5.5334839,5.8712573,5.5354356,5.5477098,5.7766603,5.6852268,6.1314855,6.0106185,5.5451061,5.630068,6.0524768,5.6734613,5.7210505,5.7673018,5.7869777,5.6704418,5.711089,5.6644286,6.1036427,5.9136593,6.1968265,5.8623575,6.1928434,5.7625382,5.9890129,5.8851527,5.8484197,5.9865585,6.0356116,5.8232467,5.7428909,5.9178664,6.5446573,5.8951754,5.9873661,5.8508928,6.3695138,5.8859946,5.6525916,5.8276873,6.0074129,6.2236419,5.3327736,6.1996795,5.8600819,5.6473481,5.8785412,5.868838,5.9649213,5.5773007,5.8954526,6.1444689,6.3563943,6.2067538,5.8002245,5.1975344,5.8733346,7.6340033,6.0069489,6.0680165,5.9133173,6.0509573,5.9507388,5.7722485,5.7741806,6.2172088,7.0693492,5.9655719,5.9797068,5.2880176,5.2820459,5.3222519,5.5675119,5.2827174,6.2894154,5.6677671,6.4085505,5.8949727,5.7703341,5.6381692,5.6322154,5.9862612,5.8497977,5.8279011,5.8319596,5.7846776,5.9052402,5.4312332,5.5740007,5.8370008,5.7705446,5.1964506,5.9514072,5.8962364,5.7520821,5.7282319,5.7512047,5.9067564,5.9410109,5.8649735,5.7960861,5.8595612,5.9326282,6.1432636,5.91886,5.9206544,5.9155419,6.2892754,5.846466,5.9999175,5.9266074,5.9511413,5.8714042,5.9266529,5.8572676,5.9505909,5.9598314,6.2836013,6.2992248,5.5063223,5.2247172,5.2057703,5.6565571,5.8714069,6.0034299,6.0233642,6.054698,6.1013582,5.937214,6.0097853,6.1145762,6.0529665,6.0289727,5.9926522,5.6671868,5.357768,5.5803089,5.4455667,5.4013098,5.1130609,5.26859,5.482087,5.4960405,5.2326224,5.436263,5.7932574,5.5727908,5.70345,5.7392515,5.3099629,5.3963397,5.6760636,6.0343678,5.8546658,5.9417634,5.9027848,5.8857158,5.1447455,5.5878459,5.7713993,5.8887784,6.1333411,5.9952942,6.0083312,5.8764089,5.6330734,6.1953252
+CAOV3_OVARY,ACH-000713,6.7458683,5.5832281,5.5810702,6.5259859,5.9633016,6.1048213,5.8928064,5.7951505,5.885665,5.8215225,5.8529989,5.487865,6.609159,5.1060698,5.154965,6.1877479,6.0688784,6.0653828,6.1447695,5.835883,6.0274579,6.1211075,5.9915013,5.924174,5.8253207,5.7804825,6.344918,5.6708941,5.900054,5.970026,6.1556782,5.8238306,5.9047614,6.0372993,5.8612961,5.4799612,5.4742448,6.1179324,5.9084347,5.9127765,5.9629717,6.0000786,5.9645276,5.8904044,5.8680064,5.8287976,6.2019095,5.7853419,5.8106304,5.6711473,6.1160302,5.9738364,5.8430241,6.0435808,5.7328398,6.243041,5.3400924,5.7203787,6.2150244,5.8428847,6.2529724,6.4633211,6.2044471,5.6799299,5.9267654,5.2804404,6.184949,6.1124861,5.760424,6.5224304,6.4976805,6.1697394,6.1564004,6.4228846,6.3435021,6.3342886,5.5858485,4.7843299,5.8092672,5.9048151,5.6115872,5.9648756,5.9354416,5.9519091,5.7081207,5.8281194,6.3708698,5.8042957,5.9582369,5.8774668,5.5403929,5.8837225,6.1329866,6.0737498,5.0435126,6.3445082,6.3541422,5.9741349,5.9653928,6.0565184,5.5105233,5.8193344,5.8535709,5.8656826,5.7705303,6.3782926,6.5807621,4.7954431,5.9288876,5.7084708,4.6917413,5.7823866,6.1094477,5.8583435,6.199512,7.795489,6.2484149,5.909491,6.0962812,6.1678046,6.1075523,5.9864959,5.8515049,6.6714273,7.0332591,6.1532491,5.8815571,7.2150687,7.6040337,7.9327642,8.0771157,8.0618591,5.9508466,5.9199642,6.0185171,6.0367633,5.3832993,5.7203154,5.7064803,6.1845016,5.7594794,5.7544297,5.7130822,5.6208154,5.8937532,5.9109523,5.918883,5.636818,5.628506,5.5720549,6.0782179,6.0166597,5.8173148,5.9762855,5.6200336,5.8138067,5.9326263,5.8621141,5.8839763,5.8360508,5.8964645,5.8340513,6.0621243,5.8713242,5.7408676,6.2725051,5.8596511,6.1358496,6.0815222,5.9786587,5.7952928,6.0832347,5.9583123,5.8204698,5.9042045,6.3102926,5.8951959,5.1677597,5.6002622,5.5938427,5.6932899,6.0535084,5.9560701,6.0309079,5.9205765,6.0204976,5.8576903,5.8200719,5.976976,5.993963,5.8302356,6.1684022,5.7466956,5.5174641,5.5149096,5.5121826,5.6460807,5.569252,5.4611008,5.6062244,5.7362051,5.5592899,5.3677527,5.6663004,5.5097331,5.6826248,5.7900338,5.5632352,5.8661999,5.8218346,4.9741027,5.6151038,5.7591894,5.6584515,5.4190981,5.2565231,6.0372721,5.641139,5.6365057,5.8648504,5.770647,5.422721,5.881577,5.4997024,5.7396044
+HEPG2_LIVER,ACH-000739,6.4694717,5.5488126,6.5454702,5.7204296,6.1679431,5.799731,6.8725235,6.4119602,5.7321113,5.9628045,6.0480324,5.9820242,6.7762135,5.5420962,5.9517383,5.4005716,6.4849718,6.60962,5.5660399,5.9810056,5.7789172,5.806314,5.9058737,5.6249567,5.644965,5.7121371,5.3349148,5.3624466,5.7789007,5.703234,5.6538066,5.936406,5.6014308,5.7168059,5.5624638,5.8493343,5.9796482,6.2411375,5.8790049,5.55418,5.9737234,5.7829168,5.7409598,5.7826214,5.8449009,6.0259137,5.9512743,5.906154,5.7216569,5.7191208,3.5103601,6.1775543,6.3506008,6.2452583,5.2995289,6.1915951,5.3522178,5.5542478,5.9185216,5.9821728,5.7985986,6.2118461,5.6961,5.7351076,5.9506436,5.3858662,5.817534,6.0956724,5.7651701,5.9358933,5.8563049,5.4671221,5.612869,5.8264725,6.1622461,5.9301527,6.0968783,5.5257019,5.9942972,6.0437587,5.833504,6.4702266,5.6907289,4.4106487,6.0994202,5.9502938,6.4270618,6.0021414,6.1813923,5.9091278,6.1225123,6.0773222,6.5261775,5.8562347,5.4057517,5.8046363,5.9295396,6.0177825,4.9372723,6.0581655,3.6871829,6.2987474,6.0189812,5.8399378,5.8192614,5.2151727,4.4614629,5.4662639,5.9464564,5.5218,5.7573753,5.8440785,5.2360249,6.7829234,5.7581596,3.4228594,6.1804858,5.4307393,5.4197799,6.1374418,6.2108248,6.5038942,6.2168174,6.3792629,5.6424242,5.8742442,5.6567992,6.3833454,5.9029216,5.1432064,4.6317477,5.544427,5.677494,5.6242918,5.2070671,5.9255307,5.8482569,5.9552145,5.7786517,6.0610827,5.8452209,5.6594745,5.8545602,5.6157124,5.7994631,6.1377434,6.1947926,5.6783556,5.6178388,5.5511267,6.2921933,5.9201194,5.865092,6.1444817,6.2633868,6.0154893,5.7960747,5.8578076,5.8839763,6.02241,5.958704,5.6847266,5.8882701,5.850812,5.8549291,6.0680867,5.8038465,5.8749731,5.7516495,5.6924866,5.610881,5.8428682,5.9236985,6.0525755,6.016617,5.7981884,5.3744328,5.5014309,6.5749474,6.5736389,6.0475352,6.0906571,6.04763,5.7019464,5.4823844,5.6950062,6.1184117,5.7517246,5.7897622,5.6895771,5.6193659,5.9471106,6.5621515,6.4464028,5.9820436,6.761301,6.543315,6.3185271,5.9806592,6.5149981,6.4285937,6.283941,5.4970261,5.961111,6.2366222,6.3188687,6.4038123,5.9388695,6.0654971,5.8392336,5.9467906,6.1918453,6.4350411,6.2443793,5.8582883,5.658104,5.9979929,5.7864168,6.0005517,6.1073141,6.4480486,6.2758557,6.0409883,6.4446899,5.6044332
+NCIH524_LUNG,ACH-000816,5.8149919,5.7149778,5.6948272,6.0288335,5.5811466,6.0793679,5.580887,5.7786733,6.4819144,5.8091232,5.7016441,6.3062953,5.9406063,6.279817,6.170397,5.6848414,5.7074621,6.0927304,5.2857139,5.7980661,5.5537595,5.154806,5.8081563,5.9304816,5.5477472,5.280214,5.619527,6.1056044,5.8427823,5.5092817,6.5479237,5.8746981,5.7823338,5.9096161,6.3623589,6.3605441,5.5769022,5.6402752,5.2745017,5.3182318,6.4029076,6.1426908,6.5146179,5.6035625,5.2572665,4.8105222,5.3799901,5.5577407,6.3420553,5.5461226,5.8196697,5.9270757,6.0554317,6.0712887,6.2006621,6.2386225,5.2560269,5.7234859,5.8583815,5.7250116,6.1665175,5.8839763,5.3831602,5.9015988,6.0745252,5.7427926,5.9045651,5.0825166,5.2213575,5.2220796,5.8570155,5.409947,5.4248524,5.4852313,5.3601005,5.472478,5.4858089,5.6140303,5.2171385,5.2688469,6.2899274,6.0415768,6.2111151,6.5743569,4.9719731,5.4839287,5.9876229,4.9707625,4.9366107,5.2720417,5.8491109,4.7788318,5.7160629,5.0603659,5.7362624,5.2931706,5.9805801,5.3599424,5.6367652,5.0268702,5.9740881,5.7697599,5.386408,5.4507985,6.3323703,5.7556923,5.785384,6.1819499,5.8596564,5.519492,6.3983351,6.0673012,5.4598992,6.3001333,5.3869954,4.8501059,5.4481093,5.974918,5.4824004,5.410644,5.2363453,5.2740569,5.361917,6.0642374,6.0400663,5.5717305,6.0790883,5.8572634,5.8218081,5.8847292,5.9289615,6.0547101,6.0565399,5.9262181,5.8458313,5.5158857,5.9464917,6.1352135,5.9265866,5.8897292,5.948674,5.8120064,5.3809247,5.9162476,5.739367,6.024971,6.2565949,5.7233768,6.2394891,5.7040608,6.5973776,6.3677477,6.1429829,6.3993924,6.1012899,6.2293098,6.2660904,5.9269249,6.1927816,6.2075485,6.1451252,6.2717593,6.3509146,6.2179183,6.1387511,6.2211669,6.2962679,6.0765173,6.4125708,6.2851343,6.098313,6.5395524,6.5550396,6.2269073,6.226095,5.4877207,5.1900748,6.1923476,6.4982992,6.2077875,6.3541155,5.6917754,5.3975191,5.1112355,5.5483923,5.4347907,5.0392715,5.3679209,5.4352677,5.4039824,5.2279099,5.6109092,6.4892305,6.5029252,6.4192651,6.4092299,6.288155,6.4977841,6.3848844,6.2236371,6.1730765,6.2714925,6.3781708,5.9085671,5.9144367,5.9695114,6.0403753,6.2108924,6.189159,5.9012607,5.8856127,5.855561,5.6752031,5.8880695,6.0298084,6.3117622,6.1088602,5.7492817,5.968263,5.7968046,5.5495174,5.7890033,5.9905315,5.6792265,5.9043005
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+HUH1_LIVER,ACH-000475,5.9918659,5.6911512,6.451276,5.9923625,5.8287477,6.2993811,6.050444,5.8270782,6.115613,5.8955214,5.6498564,6.0072861,5.6587389,5.1530639,5.4989257,5.8535704,5.8580551,6.6118627,6.12986,5.7655053,6.3039839,6.8747955,6.4319329,5.8675655,5.724937,6.2659182,5.9850536,6.085756,5.6158008,5.8429365,5.9308497,5.6611367,5.964413,6.0594669,5.9024246,6.1395075,6.1618137,5.7432451,5.9386603,6.3543999,6.1717946,6.1622656,6.0611838,5.692568,6.1058693,5.9583037,6.0096446,6.0530939,6.2825774,6.5316168,6.3610585,5.8076295,6.0913779,5.1244875,5.5170631,5.992085,5.5329833,6.0091073,5.8094148,5.8306109,6.1852411,6.513865,6.1964848,5.5693908,5.7145353,4.7566527,6.1968597,6.2089399,5.7022529,6.6472143,6.5294436,6.1639195,6.1553791,6.5016071,6.4446645,6.2567838,5.154306,4.8813931,6.0231067,5.7965422,5.787341,5.4276031,4.7272158,4.7832969,5.6565474,5.8108459,6.2887884,5.7989003,5.9412167,6.023487,6.025582,5.8797972,5.9644842,5.9765023,4.8379414,6.4170332,6.6099187,5.7846007,5.8487693,6.2447919,6.184178,5.6697907,5.7862836,6.0565889,5.9400526,6.426963,6.0149624,5.8200506,5.99946,5.5423788,5.6685612,5.9931571,5.3310473,5.5535407,6.2117432,6.2740988,5.6747997,5.3266975,6.0545792,5.7206244,5.9446151,5.9446886,5.6822813,5.499214,5.4133569,5.8839763,5.6506617,6.0754173,6.1523372,6.0806226,6.0336129,6.1204657,5.8014018,5.7871471,5.9372953,6.0715049,5.7574482,5.9692327,5.9341335,5.9551214,5.9428631,5.7214021,6.088584,5.2643878,5.8566753,5.4676878,5.9471721,5.4719286,5.6495269,5.3687057,5.6484912,5.7313282,5.3038428,5.5287448,5.3298538,5.7401373,5.5590238,5.60313,5.7340848,5.7957125,5.7414978,5.4040415,5.6769021,5.6370641,5.6364151,5.3390093,5.6226267,5.210579,5.4191383,5.0492519,5.872636,5.3591973,5.9088106,5.769708,5.7546646,5.2747426,5.4570473,6.4170826,6.4594309,6.5945023,6.2156035,5.5776652,5.5300817,5.4333574,5.3158143,5.3291125,5.6246603,5.440288,5.4236524,5.3764179,5.4924031,5.6679348,6.2678957,5.8741255,5.7197531,6.460327,6.1911585,5.8658411,5.6643541,6.3510371,6.0320205,5.9402935,5.8278565,5.7439346,6.1346175,6.1685242,5.9445262,6.0154752,6.1115319,5.5785516,5.9254028,6.0088673,6.018396,6.0205391,5.9648498,5.7771711,6.05133,5.5954547,5.9237117,6.1390778,6.1646242,6.1742901,6.3520632,6.0650074,5.822052
+MDAMB453_BREAST,ACH-000910,5.6738042,5.983045,6.5334485,6.0817591,5.9335927,5.4465847,5.9184212,5.9224041,5.9882742,5.896858,5.983143,5.9855267,6.9985504,6.3204308,5.8840224,5.798838,6.0927023,6.2395141,6.0430889,5.9062457,5.5894358,6.1990102,6.0690694,5.9745024,5.5879644,5.9320033,5.6962275,5.5512172,5.8391071,5.4620707,5.6553552,5.8438425,5.5919651,5.9791748,5.8656838,6.2067678,6.3309176,6.078146,5.7393958,5.885125,5.6699004,5.8752349,6.1027447,5.7526679,5.8822753,5.3782949,6.0406334,5.7814468,5.7764373,5.6885035,6.1078159,6.1981483,5.844504,6.5580511,5.92867,6.4019984,5.4788135,5.5440706,5.998036,5.3515302,6.2197945,5.8576074,5.9357915,6.0640179,5.8898664,6.206278,6.2310834,6.0053353,6.1716228,5.9440813,5.8525971,5.9146401,5.9172961,5.8430505,5.886691,5.8641576,5.6703667,6.1268521,5.8988572,5.8084232,5.6753008,5.7909199,4.4793148,5.3547871,5.9233368,5.8831799,6.1486431,5.7930145,5.8253181,5.9486372,6.108545,5.8101526,5.7249942,5.8509933,5.4317255,6.0138398,6.0080826,5.8219735,5.8726107,5.7872565,6.5337998,6.0293229,5.747528,5.8541081,5.9810475,6.0606045,5.4874815,5.1017346,5.6939654,6.5984117,5.6151563,6.1470406,6.1111596,5.1790375,5.9872843,4.2171824,5.8040754,5.7531862,6.0269893,5.8499522,5.8078255,5.6174674,5.74107,6.4174,6.7111372,6.3604407,6.1624704,7.1723645,7.044028,7.0123363,6.8112014,6.6936815,6.0765561,6.6448341,5.3563504,5.6890432,6.3509322,5.9540856,6.0838204,5.9330693,5.8795328,5.8052981,5.8508987,5.76873,5.7537822,6.4497977,6.2843189,6.1674002,5.6196495,5.324547,6.0233528,6.1436373,5.7499864,5.8523474,5.9557029,6.0030647,6.0848983,5.9235525,5.6678638,5.8466363,6.0131648,6.0389571,5.3685771,5.3998948,5.6710825,5.7821183,5.5515714,5.7634426,5.7465582,5.8839763,5.9488819,5.991575,5.6936386,5.6787794,6.0003783,5.5939812,5.9380928,5.976605,5.95592,5.422735,5.8643198,5.816221,5.8723034,5.9631803,5.8596309,5.9621864,5.894579,5.7549212,5.8965796,5.9893313,5.8083983,5.7130729,6.328065,6.7520897,6.7041796,6.0086772,6.3301018,6.5888243,6.8229583,5.8101603,6.1059504,6.3989401,6.6901729,5.7454682,5.6873157,5.7182523,5.8487555,6.2280148,5.538693,5.3691574,5.5155179,5.2049016,5.4788648,5.6345517,5.8162367,6.0597754,5.0331596,5.4114974,5.2524506,5.352476,5.187338,5.51416,5.2472332,5.1354081,5.1395198
+PANC0403_PANCREAS,ACH-000235,5.7790887,6.2304597,6.2966666,5.1682629,5.9537345,6.2700539,5.6751204,6.1509113,5.8114802,5.9479165,5.8460346,5.7859301,5.2138546,5.7171117,5.7362438,6.4930272,6.0541688,6.0508351,5.4906499,6.1123824,6.0999617,6.3391267,6.0286826,5.9021295,5.5070302,5.6355084,6.3613876,5.4871468,5.6080202,5.9750803,6.0492168,6.0508241,6.1283473,6.1879921,5.6192103,5.0305512,6.366346,6.254774,5.8778952,5.7879893,5.8324063,6.2524259,5.8438524,6.1185944,6.0025921,6.0812456,5.4307051,5.9877175,6.6053955,5.7704281,5.5749032,6.2576068,5.770976,5.9671465,5.8513775,5.5722239,5.7232532,5.9351066,5.6174554,5.9708614,5.4252449,5.4467743,5.6440552,5.7147199,5.6791754,6.1349151,5.1518006,5.5928783,5.8343391,5.3191354,5.4085134,5.6431659,5.7071098,5.5696135,5.6458446,5.6872076,6.1312578,6.2449092,6.0519645,5.9642049,6.0690419,5.6639031,5.7463263,6.5962518,6.131247,5.8904322,6.0756817,5.8933513,5.8986493,5.8855918,5.9256594,5.8233747,6.3279442,6.1412442,6.0792378,5.6602095,5.7487551,6.0064744,5.6723159,6.4905137,4.3794779,6.2678263,5.9420773,5.9886641,5.7647728,5.3238297,4.334549,5.7603704,6.0171333,5.9980342,4.8109804,6.2047754,5.2437695,6.3699714,5.6628966,6.5764759,6.0989596,5.8474872,5.7260984,6.0689867,6.1463128,6.1338184,6.0828148,5.7162438,5.9151794,5.7461259,6.0303919,5.58185,5.2341907,5.0296145,5.4659934,5.1056285,5.5749595,6.0606129,6.0814836,6.1125258,5.5505708,5.8465457,5.6637035,5.768318,5.734137,5.8368687,5.7615249,5.7911309,5.8395339,5.6734471,5.6116641,5.9360202,5.7763113,5.5839244,6.4464496,5.914059,5.6653739,6.3543771,6.2869078,6.0670633,5.8712396,6.0712075,5.7147523,5.8188575,5.9570815,6.0191523,5.6214829,5.5978922,5.6830567,5.8273222,5.5685579,6.0998029,5.8753128,5.9344908,6.0655065,5.7164078,5.7741944,5.8839763,6.0428747,6.0876515,6.4614149,5.6938122,6.0072561,6.1131469,5.9966775,5.9303071,5.95856,5.7423725,5.797567,5.8166183,5.926987,5.9472749,5.9734657,5.7322411,5.8522382,5.8812379,6.469832,6.1629091,5.9243038,6.9702289,6.4389915,6.0696237,5.5797096,6.5256,6.3065047,5.882001,5.8467422,6.1315187,6.1409665,6.2184786,6.063366,5.9634021,6.130284,5.7346851,5.7034913,5.8927758,6.1621235,6.1134216,6.0152924,5.6298706,5.7270397,5.5469355,5.3986697,5.5357929,5.948775,6.1773906,5.6809054,5.8340878,5.6405762
+TYKNU_OVARY,ACH-000430,6.0146871,6.020838,5.6124656,6.4322893,6.0588238,5.5015836,5.9198053,6.1896478,5.7352658,5.884605,5.9903915,5.5738568,6.5197578,5.5625314,5.8512272,6.1881881,5.8564154,5.7014319,5.6337188,5.9059148,5.9440752,5.9079841,6.0064322,5.4775901,5.4615222,5.9856836,6.1594188,5.7107901,5.6900131,6.0432921,6.2492865,5.9181172,5.840314,5.9106979,5.8999321,6.1365259,6.3108332,5.9665569,6.0258271,5.9852812,5.7698775,6.1993428,5.4519011,5.6818249,5.6998791,6.236452,5.1752394,6.0338371,5.8591467,5.9543916,4.9548347,5.0871503,5.9997495,5.4291019,5.9013077,6.3237876,5.1921595,5.9996977,5.8088933,6.0189501,5.6292075,6.2912492,6.0394974,5.7479901,6.0359891,5.8310413,6.0257322,6.1806008,5.9727007,6.2568135,6.2943641,6.0277051,5.9984222,6.2873487,6.2044617,6.2522601,5.8637399,5.576057,5.6313984,6.2409523,5.7640201,6.1152021,6.6035032,6.3907357,5.9249246,6.0342726,6.4139627,5.9079892,5.9612606,6.02767,5.829489,6.1556959,6.0242958,5.8931691,6.754791,5.952559,6.0171168,5.8684544,5.8115995,6.410135,6.4894757,5.7640294,5.8794122,6.0254503,6.257561,5.7457123,5.7555656,6.806947,5.8912943,6.1801212,6.5415569,5.8873383,5.8839763,5.513421,5.9884924,7.5465126,5.414212,6.1274197,5.7906367,5.2883959,5.2362633,5.4856559,5.3327771,5.7463986,5.0635591,5.4871261,5.7718129,5.2511046,5.144934,4.9576751,5.261175,5.2735925,5.7115399,5.848287,6.0728586,5.8567385,6.3962941,6.1568824,6.5863829,6.2590469,6.4379807,6.7848773,6.3296298,6.5943872,6.2220984,6.3547324,6.1087924,6.8369779,5.9661296,6.2262392,5.5801217,5.7863005,5.8195788,5.6595694,5.7602927,5.7498802,5.8104722,5.7693865,5.9924502,6.0472678,5.7847118,6.1175825,6.1011231,6.0983961,6.0460136,5.6224701,5.8402355,5.913975,5.982113,6.0322286,5.3548993,6.1013426,5.8434992,5.9897509,5.7984323,5.7596041,6.5020608,5.3722551,5.8325634,5.8411023,5.829264,5.8812936,5.9748263,6.0126105,5.8498084,6.0487479,5.8941331,5.9337585,5.951493,6.0392506,6.1508419,5.8659332,5.4718609,5.3738204,5.6890542,4.9412956,4.7769789,4.9302807,5.8103229,4.9399229,5.1246174,5.4857574,5.7820463,5.5624676,5.304847,5.0866416,5.3481483,5.4863753,5.4531198,5.526179,5.2305994,5.0686019,5.125391,5.2330095,5.5932076,6.0182679,5.7439978,5.7878405,5.4627189,5.167394,5.1248535,5.2874379,5.5669991,5.3218991,5.6704336
+OVISE_OVARY,ACH-000527,5.860331,6.2272449,5.7885479,5.5385206,6.1193595,5.796206,5.9772821,5.9383962,5.7345729,6.0214929,5.8542702,5.9097515,5.3550647,5.8424481,5.5080098,6.1737937,6.1843678,5.8005597,5.7618005,5.6119991,5.594912,6.3756664,6.0747825,6.1438251,5.8335823,5.8196203,6.6235355,5.5714929,6.4757912,5.9190939,5.5843159,5.6197403,5.8561516,6.5015727,5.626642,6.1117497,6.1890831,6.0124247,5.7182782,5.9352392,5.8393474,5.6886113,6.1028381,5.8432557,5.9060568,5.9939523,5.9951999,5.7448911,5.34457,5.8024485,5.5510419,6.0925254,5.6937839,5.5568445,5.7736089,5.7877923,6.0125826,5.873825,5.9657841,5.7716718,5.1989615,5.9702134,5.8048628,5.5565888,5.6042134,6.1602136,4.4317498,6.2885532,5.9727067,5.9410799,5.9423623,5.780703,5.6763508,6.0565327,6.0400456,6.1762378,6.1849654,6.2644259,6.5201129,6.336098,6.1685496,5.8648555,5.9290221,5.5973568,5.8723852,5.9280098,6.4349906,6.1001793,6.1289364,5.8776949,6.1039545,6.0139453,6.0849933,5.9846365,5.8915951,5.5581286,5.705565,5.859092,5.7443358,6.3000833,6.4356462,6.0606587,5.8733302,5.9563994,5.7704852,5.8915082,5.950256,5.858463,5.7843249,5.6542309,5.5028258,5.6926306,5.7881468,5.9174684,5.8313382,4.323785,5.9175868,5.9203683,6.1447191,5.8256409,5.8055657,5.8112597,5.8904554,6.1774806,5.5954804,5.7116417,5.8253892,6.0209348,6.0047438,5.9389172,5.9702056,5.9813515,5.7332905,5.7570485,6.3475379,5.8978179,6.1723457,6.0927597,5.8736426,5.9149572,5.8719367,5.6922525,5.9299214,5.6720924,5.9151662,5.7889526,5.7927637,5.462217,5.8527597,5.4861907,6.4024702,5.9820599,5.9264704,6.1862073,6.2889717,6.0761318,5.8397071,5.6831225,6.0061282,5.8839763,5.9276616,5.7186277,5.9948053,5.9935069,5.8989388,6.2794641,5.6943065,6.2165726,6.1943426,6.1088291,5.3775142,6.0407655,6.0478281,5.925559,5.967383,6.2332579,6.1511865,6.4707129,6.1409273,6.3515868,5.949146,5.8260958,5.9510566,5.9763923,6.1195093,5.9912681,5.8511266,5.9241455,6.0155237,6.0331279,5.9150379,5.7640465,5.8912068,5.7537635,5.7850357,6.0612914,5.8854341,5.5470176,5.7061797,5.8578223,5.6870165,5.4399257,5.4761589,5.6237969,5.7497861,5.7669612,5.5541253,5.3319403,5.5953419,5.7537763,5.2815713,5.617521,5.676748,5.6330105,5.5501464,5.8477219,5.5271182,5.6445743,5.5497387,5.508075,5.9448777,5.9001775,5.6685462,5.5341823,5.5483328
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+BDCM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE,ACH-000080,6.0450258,5.1583255,6.1829198,6.4293454,5.734062,5.8467892,5.8973321,5.9624956,7.3693195,5.8786846,5.7803493,7.314794,5.4500878,7.0442669,5.7816949,5.2736224,5.8225465,5.5023672,4.8399516,6.0171892,5.7630028,5.9196849,6.1222475,7.06849,5.9384446,5.5015543,6.1516961,6.0021334,5.1180593,6.2079778,5.7535263,6.0711769,6.327106,5.8197628,6.075514,6.8645547,5.6097227,5.6805657,5.3974017,5.7948246,6.2797841,5.844454,7.3282043,6.335843,5.3657429,5.5570561,6.8931666,4.9291798,4.8874133,5.500576,5.4628036,4.9208127,6.1834777,6.1598751,5.9726796,6.1065677,6.2220323,6.3923676,6.2800245,5.4381177,5.9811806,5.6851439,5.2535552,6.0821057,6.2484009,6.3758851,5.7643748,4.9657158,5.4984453,4.7951389,5.3289965,5.2304298,5.2285715,5.1350712,5.1194393,5.2078827,6.2593615,6.4300121,5.253607,5.4776805,6.2071342,6.1473915,6.2094776,6.2461801,6.055857,5.5106531,5.321153,5.2863073,5.0823674,5.3900002,5.7428039,4.3889188,6.1309888,4.7597311,5.7866302,5.0446009,5.4828934,5.6397492,5.6100517,4.4681835,4.4825108,5.2242836,5.0437015,5.3596772,6.0576107,5.0404167,6.0935787,5.2871768,5.710476,5.2793706,6.878821,5.9512671,6.3668061,6.1152595,5.3914561,5.0253534,6.0344155,6.2541533,5.2592391,5.8957518,6.0391036,6.2907774,5.6396587,6.4989999,6.5130773,6.16094,6.6326888,5.6333999,5.4865129,5.6641651,5.7247623,5.2758855,6.0695263,5.3755739,5.9783185,5.4429924,6.1479244,6.0043228,5.7473525,5.6081265,5.6147826,5.8839763,5.824919,5.9921149,5.4323991,6.2816212,6.1649215,6.4152628,5.8383884,6.2307224,6.2364065,6.2136639,6.2770583,6.0354327,6.1558096,6.1417419,6.0716158,6.2826632,6.0154623,6.0845569,6.0436764,6.1571202,5.9280789,6.0052626,6.0584328,6.0189989,6.103122,5.6212583,6.1128613,5.6551807,6.2174609,5.7939445,5.3152932,6.4392671,6.0508076,5.6975949,5.6612503,5.8839326,6.123209,6.2560332,6.1128193,5.5815396,5.3556195,5.1874784,5.4463923,5.1565459,5.393946,5.4612994,5.2182678,5.0425389,5.4688608,5.4265365,5.9992259,6.1364027,6.0951748,5.1549843,6.1678118,6.1172025,6.080042,6.027695,5.9425093,6.0354737,6.0380928,5.8594996,5.8600873,5.9313666,5.9394646,5.9667873,5.8793233,5.8476133,5.8786036,5.9394135,5.794967,5.9302364,5.9029988,5.9595791,5.8631101,5.8047478,5.8872083,5.9344955,5.8851314,5.7475226,5.7183607,5.1594902,5.8907544
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+EFO21_OVARY,ACH-000308,6.0299429,5.9139845,5.8132914,6.1063995,6.1012419,6.9599959,5.9367561,6.0002505,5.789341,6.0879543,6.1834037,5.7315025,5.5535168,5.5235504,5.6587464,5.7647069,6.1323368,6.1972392,6.0105272,6.1100924,5.859841,6.2822292,6.2048598,5.8839763,5.5638919,6.2117369,5.9847434,5.8678892,7.1266074,5.7048944,6.1092238,6.1459926,5.9075156,6.0470627,5.9867548,6.4000783,5.8959108,5.9550461,5.9706075,5.9038582,5.9984455,5.8444819,6.0135036,6.24602,6.1883299,6.1378671,6.216562,6.151181,5.7969571,6.222079,5.9471757,5.5923904,5.9407288,5.5558093,5.736091,6.2491647,6.1794641,5.8133765,6.0143383,6.238045,6.2026324,5.7069877,5.7702285,6.4042586,6.1142125,6.1289738,6.1526419,5.5835084,5.9460521,5.6460077,5.7349601,5.794582,5.7518547,5.7296695,5.6564694,5.0573249,5.8509219,6.0933842,5.8885078,5.9786937,5.6844887,6.004224,6.3370006,5.9521398,5.7871505,6.0362477,5.7677493,5.9105955,5.6942813,6.0143844,5.8779021,6.0741773,6.063162,5.9753451,6.7155949,5.6864581,5.0062357,5.9745769,6.0166721,6.6879803,5.9970622,6.0120178,5.9070454,6.18046,5.8713749,5.9707881,5.9693457,5.7977369,5.9755451,5.6522301,5.6277908,5.9060356,5.7679349,5.2873267,5.9832444,7.2669726,6.01264,5.9544025,5.8680461,6.1170153,6.0479022,5.7067208,5.8140714,5.444727,5.8942751,5.7173236,5.7243473,5.8363338,5.9577477,5.9418824,5.6474786,5.997387,6.0663467,6.0696848,5.6649393,5.8886676,5.8183389,5.6040461,5.5949019,5.7848741,5.6783306,5.3996184,5.7602738,5.3637811,5.844097,6.0234368,5.8589567,5.491277,5.8417531,6.1123548,5.7507776,5.7719676,6.0046755,5.8767714,5.7853681,5.836771,5.8265103,5.7155954,6.0942057,5.8584891,5.9391023,5.5626856,6.0843635,6.1453104,6.0199088,5.6462747,5.8829234,5.7026769,5.8661967,5.5824666,6.0688907,5.8900086,5.4544705,5.9838368,5.9091412,5.560573,5.2369482,5.7205717,5.7892535,5.7815864,5.6812001,5.739549,5.9166307,5.8023791,5.8552378,6.0527582,5.9302347,5.5401414,5.9507917,6.0466662,5.9554111,5.9079473,5.7502274,5.4756462,5.7505021,5.5549246,5.3692755,5.3982653,5.747628,5.3886294,5.391246,5.7175924,5.5332345,5.8925863,5.5911146,5.6304449,5.5846896,5.4323856,5.8150374,5.9816169,5.123252,6.0083774,5.816291,5.5358467,5.5331127,6.3613625,5.8390793,6.209981,5.5910399,5.8487051,5.6773706,5.5575958,6.3773849,6.8585041,6.2104327
+A375_SKIN,ACH-000219,6.1253675,5.7572242,5.7957193,6.1358768,5.8072896,5.8446653,6.3890432,5.7792072,5.6687277,5.8477353,5.7942976,5.5690577,5.8504943,5.985414,6.0482534,6.3242616,6.2287679,6.1194651,6.3550136,5.8609442,5.8839763,5.7986952,5.8757621,5.4326328,5.6995481,6.2977405,6.0043006,6.0413072,5.7184789,5.9889097,5.9776227,5.7663521,5.5887095,5.266971,6.1255642,6.3151651,6.1658921,6.1351378,6.0718119,6.2509642,6.2209125,6.0663558,5.709424,5.9477827,6.0429575,6.3223268,5.7036887,6.0534837,6.2637796,6.334555,6.5198255,5.5612896,6.0891404,6.2871036,5.8630348,5.8086613,5.9820523,6.1882727,6.1227756,5.6344849,6.5141197,6.7870052,6.4627429,5.5518346,5.9831294,4.7618979,6.4727726,6.3771821,5.9850031,6.8775989,6.7769578,6.3975116,6.42119,6.7455275,6.6516642,6.6463659,5.3809691,4.9724747,6.0894042,6.0015677,5.4324064,6.3149076,6.6320621,5.1234294,5.9168892,6.0671428,5.9290628,5.989971,6.0274117,6.3352354,6.1076545,6.1117158,5.8988015,6.1704821,6.5157229,6.6567829,6.8531687,5.9978247,6.1989328,6.1023377,6.3320029,5.9753982,6.032295,6.0585934,6.1218344,6.5829329,5.7060752,6.5113264,6.1909994,6.0582125,6.6346368,5.9941283,5.8399366,5.6580797,6.4370404,7.0165969,5.8009699,5.8192532,6.2729501,5.8533996,5.6415969,5.9512122,5.60156,5.6396382,5.7396484,6.1385371,6.1640238,5.8170666,5.9257915,5.8360648,5.9668097,6.0782247,5.9909207,5.7283492,5.6148785,6.231135,5.8602032,5.6755873,5.6893115,5.9411638,5.8677636,5.8505402,5.9663905,5.6995098,6.2120671,5.345381,5.5841814,5.6590704,6.1467988,5.5773304,5.5008896,5.5286918,5.5373047,5.5445486,5.8034353,5.6700173,5.5878781,5.6326683,5.793726,5.7976665,5.7848285,5.3091076,5.8985357,5.9931888,5.6574549,5.2170484,5.9997027,5.3368821,5.5909772,5.1511669,6.1161056,5.8765979,5.7364658,5.8579259,5.7607036,5.274832,5.1804184,6.253972,5.4236105,5.7102585,5.2357025,6.2070278,6.1046798,5.7409246,6.1005957,6.1166207,6.2809126,6.0526903,6.3035239,6.2483024,6.3011136,6.3644599,5.6912439,5.6164969,5.8254769,5.2565611,5.6218442,5.4362076,5.6391882,5.6007914,5.5484275,5.4576127,5.6154001,5.7698532,5.8028973,5.80451,5.4504475,5.7966654,5.5931923,5.6879674,5.8596108,5.7728492,5.8372443,5.3537109,5.5438363,5.5294545,5.8448698,5.5530706,5.7746589,5.8323619,5.8277145,5.6593595,5.9064466,6.0275749,5.9893225
+HT29_LARGE_INTESTINE,ACH-000552,5.8839763,5.9005559,5.3598427,6.1720832,5.7287259,6.3460752,5.7252445,5.7124654,5.727702,5.8939681,5.6379211,5.3881735,5.4710224,6.0623046,5.8500953,6.4065624,6.0506389,5.9478747,6.0415122,6.0080901,5.9669336,6.2821538,6.1182367,6.0186512,5.9742105,5.931789,5.0203137,5.8128792,5.7431271,5.7342786,5.7969258,5.9289652,5.9494631,6.2049887,5.6035437,5.9250996,5.8392393,6.4010555,5.8108857,5.8703238,5.6698868,5.9726712,5.7368911,5.8415427,6.0842347,5.9834939,5.1595818,6.1241339,6.730769,6.5196357,4.6758182,6.6727514,5.6355051,6.4040162,5.8675632,5.8511107,5.8190292,5.7610948,6.0644787,6.022308,5.9288785,5.6894759,5.7182266,5.8533483,5.6208357,6.013221,5.2743895,5.5266616,5.6195322,5.6718625,5.761851,5.676245,5.64539,5.8293571,5.5521598,5.4581984,6.0004231,6.4568721,5.5676923,5.9247098,5.9568747,5.9980604,5.8501348,7.1403273,5.6961635,5.8855505,6.4129125,5.8711923,5.8411071,5.9530073,6.2086442,5.9797628,5.9809512,5.8585413,5.4870306,5.3359314,5.777864,5.9368169,5.940077,6.3947473,6.3413514,6.1061917,5.9455489,5.7265127,5.9019287,6.2176741,5.6078081,5.5232825,6.2039174,6.7595322,5.6367227,5.5616665,5.6106678,5.3587991,5.7490495,7.123459,5.9784009,5.9915599,6.4009692,5.7993486,5.7743863,5.5108142,5.8530855,6.849971,6.1654728,6.4171147,6.1270035,6.0602378,6.0407223,5.9036692,5.959799,5.5802534,5.8362298,5.9261001,6.1988406,5.7000489,5.7956606,5.8508556,6.0581547,6.258124,5.9383581,6.2203923,5.910195,6.1267721,6.0707157,6.1753973,5.8047279,6.3640797,5.7253089,5.5584687,5.8085209,5.9384268,6.0425977,5.7280987,5.5046707,5.7693938,5.9111115,5.872205,5.633709,5.4974893,5.7464164,5.9531836,5.8407596,5.6279111,5.4917365,5.6533567,5.5092727,5.872655,5.9546461,5.9434261,5.4233757,6.1134584,5.6407888,5.681421,5.7123929,5.7189061,6.1876119,5.3180948,5.7157431,5.8112362,5.9388741,5.5395867,5.8478627,6.0590746,5.996265,5.9051584,5.8374214,5.9912731,6.0191237,5.9734029,5.7385571,5.93823,5.6392207,6.0281722,5.8384913,5.2213927,5.9125162,6.012299,6.3255689,5.6311144,5.9664398,6.1429365,6.3799145,6.05625,5.8046092,5.6514526,5.9179469,6.2075906,6.2994283,5.7634965,5.6096213,5.3640317,5.656147,6.0514111,6.2356841,5.7924383,5.4054276,6.0631634,5.53149,5.2691017,5.3956763,6.0693025,5.9474983,6.0158346,6.1837367
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+DOV13_OVARY,ACH-001063,6.2913131,6.0255594,7.1435122,5.5386337,6.2414873,5.7710654,5.9475929,6.4263201,6.0547389,6.220788,6.1642727,6.475432,6.6908373,6.0405384,6.4653519,5.8085586,5.8007372,5.6333743,5.7247502,6.0002167,5.566326,6.1964292,5.9499195,6.7736097,6.2940535,5.9160887,5.3077211,5.850147,6.2331333,6.0893003,7.2956639,6.0767453,5.8794186,6.0322662,5.7456354,6.1762071,6.2710451,6.1419592,5.45291,5.8698882,6.3635917,5.4658341,6.1056259,6.0457489,5.8546726,5.9107024,5.5905088,5.9904023,5.695764,6.0454346,6.2824372,6.762632,5.7069591,5.5932641,5.8603897,6.7754958,6.2822803,6.0457409,6.0714397,6.2457397,5.3187698,5.7672308,5.6899752,5.8567744,6.1859117,6.3221855,6.0400354,5.8081119,6.1153193,5.6014592,5.6290991,5.8178446,5.8839763,5.7238007,5.8651187,5.778133,6.2284275,6.3940012,6.2043263,6.1351624,5.8838664,5.775735,5.5894844,5.89616,5.8982584,5.9824521,6.6294365,6.1531488,6.2631175,5.9337502,5.7262189,5.8711983,6.2417296,5.8232367,6.2541468,5.9657913,6.0648267,5.8792185,5.0808322,5.3142621,6.8707755,6.2589468,6.0672361,5.8819418,5.2107445,5.5514265,5.9999079,6.5574218,5.987557,6.793819,7.653215,5.7340137,5.6794509,6.4694833,5.9622222,4.2529509,6.3398344,5.6046955,5.9023776,6.1606056,6.293015,6.5391984,6.2308873,5.7977016,6.0141905,6.0310361,5.7969784,5.8453571,5.6925192,5.7321926,5.6606951,5.6962633,5.8706425,6.1329013,6.1080624,5.9703743,6.0092216,6.3343916,6.1074077,5.9135726,6.1732474,5.7478883,5.9310702,5.7212456,5.9459744,6.1230069,6.1833233,5.764229,5.796742,5.7180288,6.1817229,5.9357296,5.6191313,6.0421852,6.0496414,6.0058071,5.7541646,5.9402399,5.6979778,5.688735,5.9550904,5.5879283,5.2456909,5.4286194,5.7519242,5.9445804,5.4104763,5.5535412,5.7524019,5.4165019,5.7185627,5.6472256,5.7286968,5.7410037,5.7146414,5.424467,5.2284236,6.3671965,6.3556667,6.3735544,6.0855937,6.0636037,6.1229283,5.9573522,6.2055093,6.1814178,5.9868808,5.8183029,6.2145474,6.1928315,6.1464152,6.0344846,5.3258849,5.7035386,5.5644209,5.7154809,5.6526142,5.5096473,5.5686036,5.690735,5.4486242,5.3755874,5.2595842,5.7487869,5.5021271,5.3537237,5.2736271,5.0034148,5.3738238,5.5964116,5.4195901,5.1533093,5.3480133,5.1055929,4.8371014,5.9303669,5.3970012,5.3968468,5.0818623,5.3430752,4.9758586,5.172536,5.3177372,5.0913448,5.1221851
+RMGI_OVARY,ACH-000719,6.2687758,6.0422646,5.5207524,5.7999585,5.8503414,5.8174721,5.9076475,5.8472288,5.7323876,5.6563391,6.0181449,5.8856528,5.9367959,5.3685887,5.9124177,5.9732666,6.0226912,6.0396118,5.9995613,6.0789625,5.8839763,5.9938869,6.0005929,5.8450205,5.4234463,5.8500338,6.8995429,5.7899364,5.7048578,5.9601135,5.8605809,6.0792559,5.468853,5.7274188,6.035819,6.0791216,5.8369841,5.8650911,5.9989957,5.8857656,5.7058036,6.4476346,5.495351,5.7884319,5.9874629,6.3624474,5.7844328,5.9749024,5.484084,5.904504,4.6663716,6.2880802,6.0145612,5.5478772,5.7433023,5.7048142,6.2646495,6.1003687,6.139699,6.4762386,5.8875009,5.9517759,5.5518224,6.294236,5.9216651,5.8234023,6.0398396,6.2364585,5.8433193,6.0257481,5.9753839,5.4586686,4.6302609,5.7341273,5.6604901,5.9224209,6.158514,5.7277932,6.8672229,6.1119998,5.7964941,5.9402609,6.5495056,6.5387352,5.7388854,5.9377369,5.434085,6.0615043,6.1476049,5.949808,5.7995318,5.9217471,5.8227217,6.2865435,5.002266,5.6868992,4.4652074,6.3013984,6.3438634,6.160042,5.9780259,6.0790792,5.9145766,5.6959657,6.0944126,6.0744658,5.7394258,7.0209283,5.896015,6.0180883,5.337705,5.9267086,5.9047527,5.8110744,5.722037,6.0902386,6.599571,5.5228734,5.7473516,6.3510589,6.6900366,5.9155002,6.4620807,7.0804677,5.8033356,6.3693301,6.071649,6.1675854,6.0764719,6.0235983,6.0726052,5.6418416,6.2428762,6.0495365,6.1372989,6.2624811,5.9089045,5.6417318,5.9814951,6.0005176,5.8360496,5.8514805,5.7934749,5.9601885,6.1145583,6.1698289,5.9130812,6.1957606,6.0929751,6.3106647,5.2674537,5.7933496,5.8776733,5.6365214,5.6802166,5.6909268,5.9906451,5.8729737,6.1104022,5.8856436,5.7871557,5.9568758,6.3195541,6.1639301,5.8208589,5.9604273,5.7255283,5.8470403,5.8553051,6.0345888,5.8922016,6.0837532,6.062491,6.0045077,5.7746329,5.9249961,5.9445162,5.7328056,5.9611732,5.3274039,5.8495536,5.8176461,5.8224734,5.9389703,5.6713872,5.8810556,5.827409,5.8701707,5.8334874,5.9416079,5.8555645,5.8293216,5.6237931,5.5140099,5.7906315,5.3744805,5.3148445,5.7110812,6.0652379,5.165348,5.4393192,5.8373389,6.0843458,5.3480421,5.2309949,5.2628131,5.7341342,5.6946003,5.566983,5.5929869,5.6513325,5.1362902,5.4255838,5.5919414,5.6425074,5.6203282,5.4256006,5.6452044,5.3855794,5.3200133,5.5013651,5.5795672,5.2073085,5.0066703,5.4401037
+PC3_PROSTATE,ACH-000090,5.8986655,5.9939537,5.8655358,5.6457277,5.9894042,5.6347722,5.9321697,6.0741022,5.6217762,5.8565935,5.9217643,5.6874931,5.8583757,5.6072716,5.7428756,6.0579984,5.8776052,5.8876948,5.9676947,5.9997218,6.1487019,5.7188182,5.9030846,5.7568931,6.0957262,6.236252,6.9616804,6.410071,6.0562785,6.0548362,5.7774644,5.9861933,5.7121896,5.263695,5.7203987,5.9352763,5.7548386,5.8119784,5.9442275,6.049575,6.1446491,6.8175612,5.782203,5.89181,6.1008214,6.375085,5.3853009,6.3494978,5.9584807,6.1149096,4.0643905,6.1481708,5.609724,5.0611075,5.825357,5.923751,6.0874832,6.059604,5.7593585,6.1345439,5.5769466,5.5376284,5.1284814,5.7924822,5.8301884,5.6888032,5.6260006,5.7949097,5.8820399,5.9281979,5.6657218,5.1639474,4.1381174,5.2380669,5.1257815,5.3463288,6.1240649,6.0221353,6.3146369,5.8419845,5.5959568,6.267337,6.7740786,6.5448768,5.7069132,5.9297313,5.5886221,6.0208075,6.1456917,6.060752,5.8174505,6.0978874,5.3507239,6.2470024,5.8887216,5.6075673,5.0556842,6.0149285,6.3235118,6.1815892,5.2806297,5.9023859,6.0619406,6.0785708,5.8839763,6.2195593,5.4740951,6.4520463,6.1570454,6.5102493,5.2401917,5.7170575,5.4484583,5.9665796,5.6946154,5.7414477,5.9744367,6.0703309,5.4928641,5.6324003,6.4610343,5.7763947,6.0534893,6.8564121,5.444581,5.8794494,5.7464671,5.3911168,5.3320607,5.0844001,5.2102616,5.099555,5.7180527,5.7883919,5.7930609,6.1417855,5.7371859,5.6844035,5.7854989,5.6895718,5.6744338,5.5543644,5.9673549,5.7104515,5.8663155,5.6903021,5.6529891,5.9298259,5.8190227,5.4813822,5.7742142,5.9032139,5.74671,5.7893882,5.588253,5.7033915,5.7934135,5.7919183,5.9111743,5.8037994,5.6160288,5.6682625,6.0601311,5.9134863,5.6879114,5.69984,5.8130366,5.8622363,5.9340992,5.8518154,5.8090654,5.8378931,5.7536564,5.8418989,5.6201402,5.7075348,6.0822387,5.754825,5.6469963,5.6351793,5.5571259,6.0082033,6.058716,6.051136,6.1478996,6.0930112,6.0224092,6.2242391,6.1044526,6.0511317,6.1931564,6.0967271,6.0684726,5.9358033,6.0045791,6.089283,5.7894981,6.0005398,6.2826444,5.9332086,5.9535233,6.1155699,6.3898244,6.0081671,6.0511975,5.8656923,5.894472,6.0768352,5.8943713,6.1003419,6.2671169,6.1105004,5.7500636,5.8553347,6.0564116,5.9255445,6.1923223,6.1627341,6.192947,6.138554,5.7930969,5.8482485,6.04623,6.1024559,6.1820227
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+MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE,ACH-000045,5.8023977,5.4164186,6.3655095,5.8932095,5.509919,6.0759674,5.8099411,5.8884388,6.6585258,5.485582,5.5859972,6.6496493,5.0118991,6.2188308,5.4474748,5.6350724,6.2034174,6.1332345,5.8354387,5.9744552,6.7646025,5.2772733,5.4438159,6.2241331,5.663562,5.3537154,6.8031928,5.9737453,5.6971609,5.628686,5.0782754,6.0401949,5.5678919,5.2728807,6.1114139,5.7726772,5.2512356,5.6541278,5.2778443,5.5607287,5.9647835,5.9583309,6.8232771,5.8488966,5.5511689,5.5333837,6.2384211,5.449777,5.7489633,5.6610983,6.0798914,5.1591345,6.01595,6.2980187,6.1491775,5.8734254,6.0488042,5.7362923,6.0383218,5.7466854,6.1733982,6.3824453,5.6273508,5.6555764,5.9930725,5.3701324,6.0282742,5.4276131,5.1094755,5.8468694,6.3175118,5.6116167,5.5932615,5.9384453,5.9090999,5.886313,5.6485995,4.5870478,5.0857477,5.2533139,5.9135161,6.0902602,5.9871896,6.2645549,6.0818484,5.3927696,5.1122648,5.3081592,5.1708954,5.5405989,5.925881,4.888248,5.8668409,5.2195787,6.3124553,5.8008456,6.2451165,5.4010464,5.9580885,4.9946817,6.0612136,5.3076958,5.238258,5.4098061,5.7874439,6.1841779,5.686291,5.4652482,5.7221764,5.1033962,6.3415904,6.0915655,6.219292,6.3709143,5.7484937,5.007006,5.5057269,5.7742055,5.4159143,5.5048919,5.7808814,5.6099374,5.7360223,6.2240945,6.1588783,5.9725863,5.9850728,6.0267605,5.9273497,5.9223339,6.025999,5.8995983,6.0488245,5.8145826,5.6673683,5.5264253,5.9336198,5.9521378,5.8178479,5.8233561,5.7542714,5.8559319,5.5899456,5.9043221,5.4926295,6.1821121,5.8024094,6.0184072,6.0818796,5.7832806,5.8254825,5.993322,5.7784513,6.0834204,5.9426695,5.9266082,5.7466036,6.0702453,6.0544236,5.8281553,5.7017032,5.4671008,5.9958935,5.9951025,5.8266187,5.4500168,5.8145955,5.7014751,5.9235744,5.8248418,5.943013,6.1083446,5.9142287,5.8206182,6.0818862,5.5545586,5.0129804,5.8839763,5.634484,5.9991707,5.9831536,5.691866,5.0740383,5.2349666,5.325777,4.8747888,4.8292429,5.3077376,4.9757524,4.7961551,5.4684061,5.1892536,6.7152133,6.8388788,6.8236732,6.9131806,6.7254682,6.7646236,6.7369424,6.5927587,6.5114267,6.5540911,6.5583745,6.6218494,6.5333837,6.2720386,6.26552,6.4416222,6.438062,6.566348,6.5086216,6.3875241,6.1470463,6.2371228,6.4576024,6.2784156,6.4798529,6.2877511,6.3641391,6.158393,5.9777558,5.7834286,6.1439115,6.2649313,6.0633805
+WM2664_SKIN,ACH-001239,6.0859653,5.9122495,5.9364248,6.156555,6.056827,5.3265282,5.9989883,6.1370137,5.5189617,6.1504126,6.1038649,5.6936525,6.1697173,6.6492983,5.4128932,6.1731428,5.7365739,5.4302151,5.6533318,5.8086026,6.0491032,5.7134725,5.865726,5.663304,7.0135405,6.0365712,5.7821078,6.275127,5.7874057,6.039304,5.7633506,5.8274031,5.9356953,5.9101767,6.0015701,6.2520494,5.9791285,5.9606413,5.9024824,5.866658,6.1817557,5.5078427,5.6382483,6.0722378,5.7976677,6.0470401,6.0930916,5.8601138,5.8364333,5.9301195,3.7421592,5.9269814,5.9766407,6.0973139,5.7101687,6.2091014,5.740094,6.0244645,5.5934867,5.6663759,5.7968065,6.1459887,5.8471496,5.7311122,6.0089331,5.6385184,5.9910875,6.1688749,5.916506,6.0354152,6.1655273,5.857423,5.8689592,6.06489,6.0838174,5.9667444,5.9803595,5.3368126,5.8266179,5.9650453,6.2111069,5.8975048,6.6082594,5.4030014,5.7180987,5.7842769,6.0071418,5.9035495,5.9730278,5.8225242,5.6209517,5.4621825,6.1717525,6.0517823,6.7056885,5.8455626,5.8949532,5.8839763,5.7181325,5.7725389,3.9067857,6.2883856,5.8492156,6.1607809,6.0662063,5.7201093,6.2733,5.6921978,5.8833257,5.7144258,5.2792872,5.4544802,6.2549004,6.4823903,5.7687308,6.2406488,6.0458552,4.8124301,5.581567,6.0262708,6.0245217,5.9897222,5.9475353,5.9962673,5.8651171,5.7390488,6.0824383,6.0611467,5.900926,5.5621381,5.3695952,5.7597722,6.153307,5.5972769,6.0744497,5.936612,5.8749176,6.2287464,6.291854,6.1790751,6.1103615,6.4044728,6.0940035,6.2972802,5.8305076,5.9812142,5.863559,5.9746549,5.8090313,6.075905,5.8576099,6.0237241,5.934503,5.9353485,5.9061839,5.863262,5.9270995,5.56718,5.9688105,5.8363754,5.848708,5.8847193,6.1272297,5.8613066,5.7985429,5.7717684,5.980154,5.8623907,5.9145721,5.8132636,5.9687916,6.3292854,6.3047211,5.8369075,5.8327036,5.9863173,5.4666459,4.9800329,6.1320647,5.7955343,5.8249686,6.2025897,6.0212266,6.017758,6.0718768,6.1051459,6.0772955,6.1027498,6.2037508,6.163402,6.3635886,6.5516762,5.7757012,5.7743048,6.0357768,5.5026493,5.6088868,5.5506712,5.7243759,5.4854933,5.6811206,5.6638119,5.5432044,5.4563892,5.5574706,5.5965388,5.6610174,5.592804,5.5823386,5.5540491,5.7176131,5.4242639,5.5592382,5.3879809,5.1620673,5.5603188,5.5933013,5.5572059,5.3367251,5.3161001,5.3275941,5.3717794,5.5653822,5.7795278,5.5037147
+KMRC1_KIDNEY,ACH-000684,6.0417801,6.0629196,5.7629489,5.972402,5.8451541,5.5747315,5.7823072,6.4408747,5.6724062,5.782251,5.9142767,5.8538404,5.6559131,5.5491902,5.8023458,6.6968053,6.0254407,6.1803706,6.1267451,5.9858576,6.0178818,5.9941319,5.999818,5.6540306,5.8382042,5.9668741,6.2974269,6.0124939,5.3036828,6.1157297,6.5146761,5.9640797,5.9499547,5.5761078,5.7642713,5.8076571,5.9296407,6.5372624,6.2322067,5.94945,6.407222,6.1931321,5.8112002,6.0055771,5.868046,5.9311906,5.4241583,5.9071614,6.2677542,5.8421285,6.3217343,4.4188651,5.6268678,6.342571,5.7813573,6.3095814,5.8205102,6.1232323,5.922632,5.8956048,5.9846618,6.3796474,6.1667888,5.4991714,6.1587,4.8180624,6.0535502,5.9767562,5.7917472,6.5042698,6.424863,6.1368081,6.1433744,6.4074417,6.3155814,6.1954891,5.8868389,4.8022982,5.6276207,5.8839763,6.2089823,5.8246441,6.3566458,5.4545332,5.640227,5.8981948,6.3309486,5.8740524,6.0245424,5.9943606,5.843066,5.8711672,6.1010754,5.9105142,5.7351303,6.3893826,6.4620792,5.8097078,5.9743442,5.7429544,4.6838118,5.8809177,5.9641481,5.891771,5.8418919,6.0915424,5.972224,5.7074138,6.1262357,5.4802451,5.7099476,5.8191528,5.6785859,5.3082988,6.2040158,7.5230424,5.8615961,5.8454434,5.8896014,5.9624148,5.785236,5.9817014,5.9417933,5.5533281,5.7206964,5.8845062,6.1412108,5.4880871,5.2402448,4.835472,4.4363688,5.227631,5.5312467,5.8140862,6.3715247,5.9584686,5.8054794,5.9155449,6.0293675,5.971077,6.0262452,5.9770788,5.9713657,5.9805598,5.9764875,6.1607653,5.9640508,6.4538341,5.8748541,5.8805431,5.8408347,5.8213766,5.8664771,5.7851495,5.9306832,5.8121612,5.7848284,5.6411054,5.7176219,5.7710767,5.847387,5.9061343,5.6986567,5.6947418,5.8031647,5.8414181,5.6344335,5.9513462,5.8745874,5.876802,5.8887051,5.9245695,6.0966239,5.7822185,5.8759024,6.0798647,6.2030056,4.9970127,5.6209512,5.526181,5.8252118,6.1529333,6.0947968,6.0827291,6.1459378,6.1498895,6.06825,6.2701304,6.0858584,6.1849574,6.2229922,6.0545328,5.5725213,5.6758697,5.7978678,5.760635,5.499491,5.7426946,6.0249825,5.4947702,5.6381671,5.9039529,6.3933832,5.5372125,5.6124052,5.6061706,5.7194951,6.0196076,5.5007771,5.5172089,5.6622879,5.0990906,5.510936,5.7600159,6.0524296,5.5075174,5.3198328,5.4747364,5.2816082,5.4437018,5.5240771,5.966939,5.0340916,4.8467728,5.0509731
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+CAL29_URINARY_TRACT,ACH-000142,6.4295825,5.9249747,5.6450822,6.0157601,5.5161827,5.2454859,5.9050759,6.0106455,5.6259853,5.6573731,5.6508357,5.9149953,5.3619686,4.8024325,5.9334937,6.1284873,5.6895686,5.6666167,6.1823372,5.9858133,5.9279248,5.8414296,6.0130879,5.8868644,6.015853,5.9883836,5.886388,5.8436011,5.7022525,5.9197442,6.3033656,5.9467654,5.6268361,6.0571165,5.9830937,5.8122624,5.7641194,5.926093,5.7538314,5.8598106,6.2790932,6.0085754,5.5769595,5.8839763,6.0400264,6.0046887,6.0120319,5.8039718,5.8972479,6.0150594,6.3424959,5.9581759,5.889817,5.894286,5.9048943,5.8240643,5.6264141,5.855864,6.0152633,5.6655498,6.2866032,6.4173557,6.1934202,5.9440405,5.9465379,4.8180595,6.2464748,6.1834087,5.819369,6.5218155,6.4328313,6.1851924,6.1635941,6.3932256,6.2935052,6.2558501,5.3318816,4.9558058,5.7447124,5.8731118,5.4254022,6.3093594,5.6934297,5.2247387,5.6356796,5.7247835,5.5655844,5.806272,5.9475816,5.789807,5.7299892,5.8504481,5.3533652,5.8867327,5.5494812,6.3274147,6.3734628,5.8245849,6.020805,5.3808583,4.2469865,5.6320788,5.776395,5.9277339,5.931098,6.3051342,5.9612993,5.7458579,5.8276034,6.1001883,4.9616733,5.9472568,6.1828597,6.2214034,6.16073,5.1491611,5.7267813,5.2326138,5.9700644,5.877844,5.3629142,6.4107976,6.1340351,5.7065907,6.2470397,5.841401,5.8729459,5.8352399,6.179448,6.2626635,6.0998457,6.1756212,5.8214318,5.9964402,5.354947,5.9189335,5.9621822,5.9426485,6.2047162,6.2361525,6.1135614,6.3376812,6.072787,6.2838616,6.1738831,5.6470619,5.7949257,5.8016674,5.7917292,5.9874995,5.54257,5.7073694,5.7373713,5.6503968,5.7232515,5.8214703,5.8828061,5.5623878,5.9788103,5.9809772,5.9184319,5.9014412,5.9702597,6.0351245,5.9588942,6.1769869,6.2472281,5.9502273,5.9132868,6.0332844,5.4730869,5.9692492,5.5388297,5.870787,5.9213708,5.9644286,5.7382829,6.0435119,5.6490935,5.9669086,5.7225865,6.1561713,6.3895328,5.9032018,6.0258435,6.3381419,6.1278701,6.0715457,6.1740524,6.2323309,6.1793607,6.1928047,5.6370976,5.5569544,5.7213538,5.3056532,5.5931767,5.2935438,5.1580127,5.5887403,5.5006521,5.2651835,5.2812751,5.7722015,5.5424524,5.6019213,5.5171729,5.2945613,5.8620947,5.6608411,5.6465282,5.5841325,5.7272033,5.3633467,4.9209119,5.6344409,5.4807881,5.8312181,5.5622434,5.565983,5.6493925,5.4387978,5.6821094,5.566787,5.7833444
+KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE,ACH-001106,5.4366629,5.8126322,5.3576502,5.7284106,5.6482975,6.5334579,6.307087,5.8193241,6.345763,5.6016545,5.1820384,6.2211567,6.1511673,5.6587124,6.00569,6.0053686,5.7316713,5.3575038,5.786792,6.121474,5.6700128,5.7812571,5.5370465,5.9086532,6.4530982,5.2842553,6.2901565,5.7439982,6.5458503,5.5425096,5.0230144,5.8628579,5.4785943,6.1091927,6.3996161,5.0293223,6.0769577,5.6201641,5.7231437,5.854458,5.5603428,5.9096149,6.1105181,5.3656206,5.5351899,5.5653635,5.552436,5.3818066,6.617344,5.719742,5.298952,3.934177,6.1742497,6.4725802,6.4089673,6.0304317,6.2766087,6.0624198,5.7266617,5.6159825,6.258364,5.8510517,5.4996497,5.8607172,6.1115576,6.0643659,6.1258173,5.3897968,6.0967534,5.6664899,5.7056402,5.5256508,5.5392261,5.5083602,5.4785161,5.5908498,5.8624806,6.2217761,6.2033167,5.9023739,5.8803947,6.1601039,5.4808203,6.1681814,6.3049135,5.8839763,6.3692935,5.5999892,5.3685614,5.644836,6.1151592,5.4428081,5.8506478,5.6435346,5.0874284,5.3676271,5.8753217,5.7817999,5.7980401,4.531034,5.9041862,5.8176523,5.475248,5.907841,6.3497507,5.8692958,6.2931715,5.9995761,5.4815026,6.3353717,6.8075529,5.6167984,6.6606403,5.5781757,5.6064998,4.5360601,5.5019337,6.5446754,5.8188524,5.198286,5.2697243,6.0113969,5.0454604,5.8137752,6.2686469,5.7749132,6.2692073,6.1259887,6.8732513,7.0724868,6.3696238,6.7382068,6.1323155,5.8455694,5.7811356,5.9057996,6.2446424,6.3739635,5.9150377,6.1147703,5.6419033,6.1184478,5.9500384,6.1008094,5.9983567,6.5886443,6.4395468,6.1008062,6.3077842,6.840347,5.5889253,5.9099121,5.7635799,6.0602095,5.7578327,5.7382267,5.7112434,6.3800494,6.3291373,6.0454858,5.8844495,5.83357,6.3177655,6.3720009,6.3515308,5.3814046,6.4911119,5.9043941,5.7544196,5.9043513,5.6946271,5.9155603,5.6783389,5.8917098,5.8256517,5.4595105,5.4877192,6.5799753,5.6131049,6.1557242,5.9538624,5.9754298,5.3782539,5.4793549,5.4796263,5.4821022,5.2855138,5.8792925,5.3977597,5.4059435,5.4475528,5.4964922,6.2922516,5.9731228,6.135205,6.1479718,5.7853684,5.6687989,6.0930439,5.8982566,5.7013431,5.807779,6.1821538,6.2859224,6.0694072,5.8658084,5.8303487,6.154769,6.3785692,6.5162821,6.4684695,6.2107424,5.9990051,6.0077235,6.0353768,6.4471094,6.5698908,6.6309517,6.4760827,6.1304546,5.883627,5.8508103,6.8192253,6.4981491,6.6780557
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+TT2609C02_THYROID,ACH-000716,5.9328384,6.0015144,6.5172397,6.1147998,5.9965106,5.7774685,5.9386182,5.6603593,5.8771345,5.8866882,5.9549935,5.8244761,5.4165072,4.8617673,5.6406764,6.3075592,5.8250866,5.6940408,5.8868469,5.717764,6.0196488,6.0089462,6.0564279,5.8567511,5.9291016,6.0091013,6.120105,5.8979523,7.1867997,5.8142089,5.4909069,5.6817726,5.559737,6.1140562,5.853293,5.7092212,5.5780434,5.8065486,6.1559466,5.9508746,5.7149283,6.3246093,5.865327,5.8199173,5.9687528,6.2543838,6.3379643,6.1232918,6.1040028,5.9224153,5.9018777,5.4034233,5.9484464,5.6987488,5.9606198,5.5212103,5.847381,5.6746656,5.7510675,5.4390826,5.8680433,5.7541544,5.8090267,5.7059892,5.79491,5.9115782,5.9354666,5.7823442,5.9289117,5.8236435,5.7938218,5.787425,5.7940916,5.7809105,5.737895,5.3267601,5.8488386,5.9270438,6.0138844,6.0931875,6.1953207,5.8907939,6.4675505,5.5208902,5.5385804,6.0249193,5.5358354,5.9115985,5.8693773,5.8938274,6.2049178,6.1680845,5.6226759,6.0282614,6.8439652,5.6973771,5.9196056,5.9137444,6.1078923,6.0566899,6.3822945,5.7469846,5.9684894,6.0415751,5.935745,5.9480349,6.6319419,6.7861458,6.0073061,6.8420785,5.5107089,5.7105411,5.8556048,5.67617,5.8195827,3.6645003,5.8263888,5.7133988,5.8727869,5.9654587,6.0422563,5.726557,6.0828568,5.5948522,5.6501284,5.7835362,5.9308478,5.4480547,5.7264193,6.0316722,6.1364341,5.7054697,5.8927587,6.1094458,6.0211066,5.9932504,5.7483678,5.4956058,5.4458082,5.8999057,5.5465829,5.781376,5.4783053,5.7452292,5.5589189,5.5082543,5.5048508,5.1482503,5.8787795,5.2163071,5.3533422,5.4522835,5.4164111,5.6663369,5.8156354,5.6953107,5.8670114,5.7938181,6.027518,5.9312128,5.7583154,6.124676,5.9852446,6.0197281,6.0678195,5.736378,5.7517394,6.0842951,5.94711,5.9614582,5.5907477,6.2163364,6.141881,5.8845501,5.7503101,5.7230819,5.6930604,6.1013749,5.4395485,5.3209621,5.7396415,5.874513,5.8540454,5.939732,6.0435775,5.9101126,5.8634613,5.8419892,5.9247478,5.9966296,5.9810585,5.8818752,5.7347347,5.6043205,5.9505289,5.5667747,5.734834,5.4657297,5.7007787,5.8064275,5.7956477,5.7647473,6.1801996,6.3607276,6.1645575,5.9121949,5.8331658,6.1090901,6.3708384,6.2920218,6.5452612,6.329305,5.8839763,6.039796,6.2502251,6.2085538,6.2688339,6.5453202,6.6218591,6.4167768,5.9654677,5.9169476,6.7386545,6.6825122,6.6966667
+CL34_LARGE_INTESTINE,ACH-000895,5.8702365,5.9607851,6.366081,6.486757,5.9198803,5.9774314,5.79823,5.8195079,6.0450279,5.971124,5.9571855,5.6520751,5.4895084,5.4312589,5.7224471,5.8353293,6.3238195,6.2246282,5.9635334,5.6196709,6.0226486,5.9613603,5.8020437,5.913768,5.714777,6.1304384,6.1927317,5.6168069,5.9612034,5.7889751,5.6870809,5.5809519,6.0335696,6.0796711,5.8224246,6.0957068,5.873882,5.9150125,5.9235176,5.9182477,5.6223908,6.3225555,5.8551214,5.8476868,6.3463698,6.3594068,5.9584115,6.1550626,5.5957675,5.9311827,5.564246,6.7183697,6.0295018,5.5582408,5.8214775,5.5667988,6.4783999,5.4104339,6.2183257,6.4865571,5.6595717,6.3504833,5.4363867,5.3029896,5.4386311,4.3161481,4.7951549,5.5789734,5.5587815,5.9877303,5.9696441,5.5377406,5.5935905,5.9404424,5.8681813,5.7181758,5.9644983,5.7169628,6.0359275,5.8053138,6.2406663,6.107348,5.1441933,6.596376,5.8892579,5.9890214,6.5512523,6.0108378,6.2460477,5.931674,5.6654382,6.1162094,5.9981128,5.8558601,4.8557559,6.1343076,6.1248766,6.211245,6.0463577,6.1658656,6.0060961,6.0795136,6.1081123,6.1197607,5.8200629,5.965438,5.981698,5.673267,6.0339354,6.3413294,5.6183015,5.742858,5.8209594,5.5025032,5.6765451,3.6853689,6.403895,5.9326625,5.5792274,6.1982076,6.5633179,6.2139507,6.0628945,6.0478906,6.2370021,6.1251896,5.852658,5.6707647,5.982467,6.0321039,5.9822897,5.6133874,6.1600234,6.4352724,6.4833355,5.984781,5.9851948,5.9793812,6.1099532,5.7985484,6.1570521,6.1583381,6.0821681,6.1031949,5.804683,5.8631296,5.8260217,6.2706782,5.8839763,5.414924,5.68974,5.774057,5.5518722,5.6242958,5.4969594,5.8039962,5.7875157,5.868903,5.660756,5.7139376,5.8208241,5.9194329,5.705182,5.5148456,5.4816857,5.4185775,5.3235088,5.8118749,5.8995917,5.9191639,5.7605754,5.7781553,5.7128648,5.6202178,5.8464215,5.4524568,5.3124272,5.7493376,5.8446658,5.7677098,5.7909589,6.0933512,5.9165456,5.7423793,5.9805652,5.9497001,5.902338,5.7229303,6.048416,6.0395482,5.8087724,6.1210929,5.7290494,5.8563189,5.9712319,5.577379,6.0193487,5.8952496,5.9962927,5.8157918,6.0201285,5.9215281,6.2466308,5.3976086,5.3761764,5.9686238,5.958764,6.1212973,5.7273112,5.7300437,5.0491072,5.3966443,5.9628048,6.0453651,5.8897116,4.8578999,5.7283371,5.6759272,4.8253758,5.2134069,5.6166803,5.8649271,5.5966876,5.4498244,5.2289623
+RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE,ACH-000922,5.4563819,5.3901941,6.8288981,5.2607804,6.2068726,6.3124926,5.5652514,5.6238732,7.4963494,5.8877121,6.000146,7.3827354,6.7074027,7.4304436,6.5710777,5.4561003,5.6184448,5.5630022,4.7902767,5.9229059,5.0940357,5.8287912,5.8702437,7.2259138,5.6386252,4.867763,4.7614067,5.2027325,5.8609042,5.4287727,5.3449919,5.9390112,5.6739884,5.3291963,5.7080564,5.4775089,5.8580259,5.367121,5.4156933,5.9147572,5.4910191,5.9519639,7.7622721,6.3997869,5.1117673,5.3339368,7.3084511,5.0212208,5.2722845,5.2209387,4.3806057,5.8188019,5.6774792,5.7420202,5.7656597,6.0721867,6.481443,5.6031012,5.9518247,6.3775667,5.3532891,5.5798099,5.2508622,5.6476494,5.9727293,6.5072721,4.027561,5.4802919,5.9857945,4.7651231,5.1276122,5.5708668,5.6926733,5.2920241,5.5948191,5.6253879,6.119441,6.7863586,5.9256896,5.7291546,6.2362967,5.6077863,5.881357,6.4240934,5.4807647,5.5539648,6.0132873,5.78938,5.8964478,5.3925113,5.7110076,5.0760098,6.7736674,5.0604547,5.7582134,5.695401,5.7992442,5.8327702,5.8839763,6.0506873,5.5726123,6.1812965,5.5325012,5.4098295,5.5645176,4.83973,5.258209,4.2760204,4.987531,5.194448,5.0898133,5.9120295,5.0547191,6.445067,5.2486472,3.6751974,6.2581774,6.3742987,5.5112232,5.8505672,6.4476779,6.3430055,7.2721553,5.7625181,6.0742531,6.5519749,6.8270485,6.3960359,6.344258,6.6156843,6.4743759,6.7180705,5.8514559,6.0484184,6.3350124,5.3490275,5.8654929,5.6375702,5.4850551,5.9525395,5.605668,5.6347049,5.7823239,5.608857,5.1539185,5.8305515,5.8490109,6.1337816,5.9280764,5.9399313,6.2129764,5.9510512,6.1458513,5.897557,5.9958307,5.9484149,5.8900266,5.4891956,5.6700817,6.1268575,5.98593,6.033304,5.6593204,5.6384066,5.9628993,6.2201269,5.9609387,5.793979,6.0567715,5.9481461,6.0187897,5.8609778,5.9814172,5.9802801,6.0758091,5.9741733,5.905059,5.6306042,6.372332,6.3560177,6.325926,5.6068869,4.8281662,4.9374606,4.8766829,4.7829254,5.0921591,5.4503102,4.5943232,4.5083288,5.0178644,5.139373,6.5431779,6.7834158,6.4755959,6.7089102,6.6324871,6.7473874,6.8329343,6.5549142,6.6588953,6.7674128,6.6777374,6.2890987,6.3304626,6.5264251,6.6844353,6.6582995,6.1328843,6.1132987,6.3515529,6.5607181,6.6075684,6.8296021,6.9553692,5.8645705,6.2813559,6.1958621,6.5970225,6.9347437,6.8633355,6.9263319,6.2980409,6.6064207,6.4143193
+CAL120_BREAST,ACH-000212,5.5956755,5.8619824,5.8839763,5.4988265,5.9629962,5.8879702,5.7939302,6.0604592,5.7166574,5.9116307,5.8940643,5.9753709,6.4465935,5.4423942,5.8011697,5.9347166,6.0488458,6.1157833,6.1053593,5.7697584,5.7651344,5.9892815,5.8571703,5.7718319,6.7836343,5.7301569,6.3763386,6.0813371,5.8336384,5.8733574,6.1453492,5.8338765,5.9220794,6.0046752,5.7113932,5.929216,6.2115409,6.0369083,5.784812,5.8638242,6.1399745,5.9462369,5.8137835,6.144641,5.7664457,5.7256245,5.8727456,5.740159,6.415096,5.5691826,5.7653235,6.3005334,5.678508,5.8059855,6.0279108,5.8513155,5.9286127,5.9772992,6.2376823,5.8919431,6.1708485,6.3811557,6.1295737,5.7651122,5.9880785,4.9728443,6.112035,5.9747867,5.7492361,6.4086888,6.2540597,6.0871714,6.0858198,6.3538055,6.2828557,6.2822259,5.8674388,5.0135879,5.6457229,5.797246,5.890963,5.9809678,5.7777414,5.2643491,5.5889713,5.8613963,6.0928694,5.7927849,5.9582158,5.7749656,5.6114826,6.1901493,5.6891056,5.7532399,6.3928404,6.35261,6.3259694,5.8628447,5.8476419,6.7523928,6.9969689,6.1552263,5.9643724,5.667012,5.866052,5.8237472,4.5433704,6.2797178,5.8311542,5.7439569,5.0479482,6.2917219,5.2605271,6.1174943,6.1047832,5.122785,5.8959281,6.1183671,6.0221447,5.8561249,5.7621093,6.5454891,5.7840373,5.5976008,6.2306887,5.7076511,5.5688827,6.0051727,5.9836322,6.1540542,5.7535798,5.8978013,5.3565899,5.6618737,5.7106904,5.761011,6.0269272,6.1735081,5.908176,5.8777263,5.9284434,5.9219558,5.9332728,5.9121593,6.011554,6.1414827,6.1640236,6.3147472,6.0408691,6.388446,5.8199814,5.8851657,5.701445,6.0188942,5.8085549,5.8626842,5.8979799,5.9257269,5.7819317,5.8422316,5.9782643,5.9962875,5.8450173,5.8414757,5.8546377,5.9658417,5.5385906,5.9471674,5.9552344,5.9472434,6.042323,5.9012356,5.8493355,5.8475433,5.9639931,5.9047639,5.9658672,5.3674866,6.3336818,6.0748533,6.2464039,6.0650649,6.0886612,5.9864446,6.057091,6.1971097,5.9978415,5.8914006,6.0237913,6.0935453,6.1679137,6.1263399,5.6657481,5.8082812,5.9426806,4.895499,5.6347448,5.7485161,5.860862,5.474077,5.4624476,5.7332697,5.7539824,5.6563874,5.3645801,5.5929957,5.6095733,5.7711654,5.7036884,5.7402838,5.5824199,5.4058551,5.4991478,5.5128018,5.6612466,5.8789624,5.5156358,5.6262813,5.3465811,5.2221293,5.2839527,5.4381765,5.3214681,5.0495372,5.1911306
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\ No newline at end of file
diff --git a/Examples/Inputs/gmt_HMDB_in_CCLE_2sets.rds b/Examples/Inputs/gmt_HMDB_in_CCLE_2sets.rds
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diff --git a/Examples/Inputs/gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds b/Examples/Inputs/gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds
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diff --git a/Examples/Simulations/DMEA_using_cell_corr_simulation.R b/Examples/Simulations/DMEA_using_cell_corr_simulation.R
new file mode 100644
index 0000000..9e9daaf
--- /dev/null
+++ b/Examples/Simulations/DMEA_using_cell_corr_simulation.R
@@ -0,0 +1,305 @@
+# Author: Belinda B. Garana, belinda.garana@pnnl.gov
+# Created: 2024-01-17
+# Last edit: 2024-01-17
+### We will perturb gene expression and drug AUC in the same directions, then
+### leave out 1 cell line 100 different times to run mDMEA_cell_corr
+### for 2 different cases: 200 cell lines and 20 cell lines
+
+### Step 1: Simulate gene expression for 200 OR 20 cell lines representative of
+###         CCLE normalized RNAseq version 19Q4, then perturb 1 set of 25 genes
+### Step 2: Simulate drug AUC for 200 cell lines representative of PRISM, then 
+###         perturb 1 drug set of 10 drugs +/- Y
+### Step 3: 100 times: remove 1 random cell line to create input lists
+### Step 4: Run mDMEA_cell_corr across the perturbations
+### Step 5: Repeat 20 times
+
+rm(list=ls(all=TRUE))
+library(DMEA);library(dplyr);library(GSA);library(reshape2);library(data.table);
+library(ggplot2);library(stringr);library(dostats);
+
+### Step 0: Prep rows, columns, values
+# Import pathways
+drug.sets <- GSA.read.gmt(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Simulations/DMEA_using_WGV/MOA_gmt_file_n6_w_synthetic_set.gmt")
+pathway.names <- drug.sets$geneset.names
+num.pathways <- length(pathway.names)
+
+# Import CCLE RNAseq data for gene list
+download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin", 
+              destfile = "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin")
+load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin")
+download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin", 
+              destfile = "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin")
+load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin")
+CCLE.RNAseq <- rbind(RNA.first200, RNA.rest)
+gene.names <- unique(colnames(CCLE.RNAseq[,2:ncol(CCLE.RNAseq)]))
+num.genes <- length(gene.names) #19144
+
+# Make a synthetic gene set of size 25 genes
+gene.set.size <- 25
+#synthetic.gene.set <- sample(gene.names,gene.set.size) #we did this once and now we want to use the same gene set for each time, so lets save it separately
+synthetic.gene.set <-  c("HDAC11","FSBP","PGF","NBEAL2","SMIM15","PRSS33","USP29","ZCCHC7","PIK3C2B","ZFAND2B","CLMP","APOL4","TXNIP",
+                         "LRRC41","ARHGEF38","KRT85","TMEM121","DPYSL2","DAZ4","C1QA","CILP","AFF2","CHAC2","BLVRA","RNF114")
+
+#Import PRISM data for drug list
+prism <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/PRISM_drug_mean_AUC_6-23-21.csv",header=T)
+prism$X <- NULL
+
+#Make a synthetic drug set of size 10 drugs - already done in "Metabolic Pathways and the drugs that target them - filtered - gmt.gmt"
+drug.set.size <- 10
+#synthetic.drug.set <- sample(drug.names,drug.set.size) # we did this once and now we want to use the same gene set for each time, so lets save it separately
+
+synthetic.drug.set <-  c("blebbistatin....","BI.D1870","PF.05212384","oligomycin.a","levonorgestrel","norfloxacin","poziotinib",
+                         "estradiol","CGP.54626","epirubicin")
+
+# Make synthetic cell line names
+synthetic.cell.names <- seq(from = 1, to = 200, by = 1)
+synthetic.cell.names <- paste("Cell_No_", synthetic.cell.names, sep = "")
+
+# How far do we want to vary values here?
+values.to.vary <- seq(from = 0, to = 0.1, by = 0.01)
+
+# Import drug info
+drug.info <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/PRISM_secondary-screen-replicate-treatment-info.csv",header=T) #481 cell lines
+colnames(drug.info)[colnames(drug.info)=="name"] <- "Drug"
+drug.info$Drug <- gsub("[[:punct:][:blank:]]",".",drug.info$Drug)
+drug.moa <- na.omit(distinct(drug.info[,c("Drug","moa")]))
+Drug <- unique(drug.moa$Drug)
+moa.drugs <- data.frame(Drug)
+Drug <- unique(colnames(prism[,2:ncol(prism)]))
+prism.drugs <- data.frame(Drug)
+overlap.drugs <- merge(moa.drugs,prism.drugs,by="Drug")
+
+# reduce PRISM data to drugs with moa
+prism <- prism %>% select("CCLE_ID",overlap.drugs$Drug)
+drug.names <- unique(colnames(prism[,2:ncol(prism)]))
+num.drugs <- length(drug.names) #1351
+
+# set drug AUC parameters
+frac.low.AUC <- 0.72
+num.drugs.low <- round(frac.low.AUC*num.drugs,digits=0) #973
+num.drugs.high <- round((1-frac.low.AUC)*num.drugs,digits=0) #378
+num.synth.drugs.low <- round(frac.low.AUC*drug.set.size,digits=0) #7
+num.synth.drugs.high <- round((1-frac.low.AUC)*drug.set.size,digits=0) #3
+low.mean.AUC <- 0.83
+low.sd.AUC <- 0.1657471
+high.mean.AUC <- 1.31
+high.sd.AUC <- 0.1580992
+half.low.sd.AUC <- 0.08
+half.high.sd.AUC <- 0.08
+
+# Run simulations (N replicates)
+N.max <- 20
+for (N in 1:N.max){
+  loop.start.time <- Sys.time()
+  
+  ### Step 1: Generate gene expression matrix for 200 cell lines and 25 genes in synthetic gene set
+  # Step 1a: make gene expression matrix
+  expr.matrix <- matrix(data = NA, nrow = gene.set.size, ncol = length(synthetic.cell.names)+1)
+  row.names(expr.matrix) <- synthetic.gene.set
+  colnames(expr.matrix) <- c("Gene",synthetic.cell.names)
+  expr.matrix[,"Gene"] <- synthetic.gene.set
+  expr.matrix <- as.data.frame(expr.matrix)
+  
+  # Step 1b: make list of varied value expression matrices
+  expr.matrices <- list()
+  varied.value.names.all <- paste("value_added_",values.to.vary, sep = "")
+  
+  # Step 1c: replace values of synthetic gene set with varied values (perturbation); Need to do 0 separately
+  varied.value <- values.to.vary[1]
+  varied.value.name <- paste("value_added_",varied.value, sep = "")
+  for (k in 1:length(synthetic.cell.names)){
+    expr.matrix[expr.matrix$Gene %in% synthetic.gene.set, synthetic.cell.names[k]] <- rnorm(length(synthetic.gene.set), mean = 0, sd = 0.5)
+  }
+  expr.matrices[[varied.value.names.all[1]]] <- expr.matrix
+  
+  for(j in 2:length(values.to.vary)){
+    varied.value <- values.to.vary[j]
+    varied.value.name <- paste("value_added_",varied.value, sep = "")
+    
+    range.to.vary <- seq(from = -varied.value, to = varied.value, by = 2*varied.value / (length(synthetic.cell.names)-1))
+    for (k in 1:length(synthetic.cell.names)){
+      expr.matrix[expr.matrix$Gene %in% synthetic.gene.set, synthetic.cell.names[k]] <- rnorm(length(synthetic.gene.set), mean = range.to.vary[k], sd = 0.5)
+    }
+    expr.matrices[[varied.value.names.all[j]]] <- expr.matrix
+  }
+  
+  ### Step 3: Generate drug AUC that have a normal distribution for each cell line, then perturb synthetic drug set
+  AUC.matrix <- matrix(data = NA, nrow = length(drug.names), ncol = length(synthetic.cell.names)+1)
+  row.names(AUC.matrix) <- drug.names
+  colnames(AUC.matrix) <- c("Drug",synthetic.cell.names)
+  AUC.matrix[,"Drug"] <- drug.names
+  AUC.matrix <- as.data.frame(AUC.matrix)
+  # Fill out matrix with normal distribution of rank values
+  # And replace synthetic drug set with a value of X
+  
+  for(i in 1:length(synthetic.cell.names)){
+    temp.cell <- synthetic.cell.names[i]
+    normal.low <- rnorm(num.drugs.low, mean=low.mean.AUC, sd=half.low.sd.AUC)
+    normal.high<- rnorm(num.drugs.high, mean=high.mean.AUC, sd=half.high.sd.AUC)
+    normal <- c(normal.low,normal.high)
+    AUC.matrix[,temp.cell] <- normal
+  }
+  
+  
+  AUC.matrices <- list()
+  
+  ## Need to do 0 separately
+  varied.value <- values.to.vary[1]
+  varied.value.name <- paste("value_added_",varied.value, sep = "")
+  for (k in 1:length(synthetic.cell.names)){
+    normal.low <- rnorm(num.synth.drugs.low, mean=low.mean.AUC, sd=half.low.sd.AUC)
+    normal.high<- rnorm(num.synth.drugs.high, mean=high.mean.AUC, sd=half.high.sd.AUC)
+    normal <- c(normal.low,normal.high)
+    AUC.matrix[synthetic.drug.set, synthetic.cell.names[k]] <- normal
+  }
+  AUC.matrices[[varied.value.name]] <- AUC.matrix
+  
+  for(j in 2:length(values.to.vary)){
+    varied.value <- values.to.vary[j]
+    varied.value.name <- paste("value_added_",varied.value, sep = "")
+    
+    range.to.vary <- seq(from = -varied.value, to = varied.value, by = 2*varied.value / (length(synthetic.cell.names)-1)) #from0 BG 20210913
+    for (k in 1:length(synthetic.cell.names)){
+      normal.low <- rnorm(num.synth.drugs.low, mean=low.mean.AUC+range.to.vary[k], sd=half.low.sd.AUC)
+      normal.high<- rnorm(num.synth.drugs.high, mean=high.mean.AUC+range.to.vary[k], sd=half.high.sd.AUC)
+      normal <- c(normal.low,normal.high)
+      AUC.matrix[synthetic.drug.set, synthetic.cell.names[k]] <- normal
+    }
+    AUC.matrices[[varied.value.name]] <- AUC.matrix
+  }
+  
+  ### Step 4: Generate data lists for mDMEA_cell_corr input
+  expr.matrix.names <- names(expr.matrices)
+  AUC.matrix.names <- names(AUC.matrices)
+  
+  correlation.matrices <- list()
+  print("Generating Correlation Coefficients")
+  for(i in 1:length(expr.matrix.names)){
+    for (j in 1:length(AUC.matrix.names)){
+      expr.value <- paste("expr_",expr.matrix.names[i],sep = "")
+      AUC.value <- paste("AUC_",AUC.matrix.names[j], sep = "")
+      
+      corr.name <- paste(expr.value,"WGV", AUC.value,"correlation", sep = "_")
+      
+      temp.WGV.results <- WGV.scores.all.var[[expr.matrix.names[i]]]
+      temp.AUC.matrix <- AUC.matrices[[AUC.matrix.names[j]]]
+      temp.AUC.matrix$Drug <- NULL
+      temp.AUC.matrix <- t(temp.AUC.matrix)
+      input.df <- cbind(temp.WGV.results,temp.AUC.matrix)
+      
+      temp.corr <- rank.corr(data=input.df,variable="Drug",value="AUC",plots=F)$result
+      correlation.matrices[[corr.name]] <- temp.corr
+    }
+  }
+  
+  ##### Step 5: Run mDMEA_cell_corr
+  print("Running DMEA")
+  result.matrices <- list()
+  Correlation <- names(correlation.matrices)
+  synthetic.results <- as.data.frame(Correlation)
+  synthetic.results$ES <- NA
+  synthetic.results$NES <- NA
+  synthetic.results$p <- NA
+  synthetic.results$q <- NA
+  drugSEA.start.time <- Sys.time()
+  
+  corr.name <- names(correlation.matrices[i])
+  temp.corr <- correlation.matrices[[corr.name]]
+  temp.result <- panSEA::mDMEA_cell_corr(gmt = drug.sets, expression = expr,
+                                         weights = weights, types = perts,
+                                         scatter.plots = FALSE)
+  result.matrices[[corr.name]] <- temp.result$compiled.results$results
+  # store synth drug set results in a separate df and save that
+  synthetic.results[synthetic.results$Correlation==corr.name,]$ES <- temp.result[temp.result$Drug.Set=="Synthetic_Drug_Set",]$ES
+  synthetic.results[synthetic.results$Correlation==corr.name,]$NES <- temp.result[temp.result$Drug.Set=="Synthetic_Drug_Set",]$NES
+  synthetic.results[synthetic.results$Correlation==corr.name,]$p <- temp.result[temp.result$Drug.Set=="Synthetic_Drug_Set",]$p_value
+  synthetic.results[synthetic.results$Correlation==corr.name,]$q <- temp.result[temp.result$Drug.Set=="Synthetic_Drug_Set",]$FDR_q_value
+  
+  all.results <- rbindlist(result.matrices,use.names=TRUE,idcol="correlation",fill=TRUE)
+  write.csv(all.results,file=paste0(N,"_", drugSEA.start.time,"_all_drugSEA_results.csv"))
+  write.csv(synthetic.results,file=paste0(N,"_", drugSEA.start.time,"_Synthetic_Drug_Set_drugSEA_results.csv"))
+}
+
+#### Run mDMEA_cell_corr
+mDMEA.results <- panSEA::mDMEA_cell_corr(expression = expr, weights = weights,
+                                         types = seq(1, length(weights)))
+#utils::write.csv(mDMEA.results$compiled.results$)
+
+
+## Generate tile plots
+# Load themes for plots
+ng.theme <- theme(panel.grid.major = element_blank(), panel.grid.minor = element_blank(),
+                  panel.border = element_rect(fill=NA), panel.background = element_blank(),
+                  axis.line = element_line(colour = "black"), axis.text.x = element_text(colour = "black"),
+                  axis.text.y = element_text(colour = "black"), axis.ticks.x = element_line(colour="black"),
+                  axis.ticks.y = element_line(colour="black"), legend.title = element_blank(),
+                  axis.title.y = element_text(size=8, colour="black"))
+
+bg.theme <- theme(legend.background = element_rect(), legend.position="top", legend.text = element_text(size=14), legend.key = element_blank(),
+                  axis.title.x = element_text(size=20), axis.text.x  = element_text(size=16),
+                  axis.title.y = element_text(size=20), axis.text.y  = element_text(size=16),
+                  plot.title = element_text(lineheight=.8, face="bold", size=36))
+
+# import results
+sim.results <- import_list(dir(pattern = "Synthetic_Drug_Set_drugSEA_results.csv$"))
+
+# rbind all dataframes in sim.resuls; make sure you only use N.max replicates
+plot.data <- rbindlist(sim.results,use.names=TRUE,idcol="file",fill=TRUE)
+
+# formatting: make columns for replicate number N, expr.value, and AUC.value
+expr.values <- seq(0,0.1,0.01)
+AUC.values <- seq(0,0.1,0.01)
+for (i in 1:nrow(plot.data)){
+  plot.data$N[i] <- substring(plot.data$file[i],1,2)
+  plot.data$expr.string[i] <- substring(plot.data$Correlation[i],1,23)
+  for (j in 1:length(expr.values)){
+    if (grepl(expr.values[j], plot.data$expr.string[i], fixed=TRUE)==TRUE) {
+      plot.data$expr.value[i] <- expr.values[j]
+    }
+  }
+  plot.data$AUC.string[i] <- substring(plot.data$Correlation[i],24,50)
+  for (k in 1:length(AUC.values)){
+    if (grepl(AUC.values[k], plot.data$AUC.string[i], fixed=TRUE)==TRUE){
+      plot.data$AUC.value[i] <- AUC.values[k]
+    }
+  }
+}
+
+#For each correlation, average NES and count nrow q<0.05 and divide by N.max for percent
+plot.data[,c("Average.NES","SD.NES",
+             "Average.q","SD.q",
+             "percent.q0.05","percent.q0.25")] <- NA
+Correlations <- unique(plot.data$Correlation)
+for(i in 1:length(Correlations)){
+  temp.data <- plot.data[plot.data$Correlation==Correlations[i],]
+  reps.q0.05 <- nrow(temp.data[temp.data$q<0.05,])
+  reps.q0.25 <- nrow(temp.data[temp.data$q<0.25,])
+  for(j in 1:nrow(plot.data)){
+    if(plot.data$Correlation[j]==Correlations[i]){
+      plot.data$Average.NES[j] <- mean(temp.data$NES)
+      plot.data$SD.NES[j] <- sd(temp.data$NES)
+      plot.data$Average.q[j] <- mean(temp.data$q)
+      plot.data$SD.q[j] <- sd(temp.data$q)
+      plot.data$percent.q0.05[j] <- as.numeric(reps.q0.05*100/N.max)
+      plot.data$percent.q0.25[j] <- as.numeric(reps.q0.25*100/N.max)
+    }
+  }
+}
+write.csv(plot.data,file="WGV_drugSEA_sim_N50.csv")
+plot.data <- read.csv(file = "WGV_drugSEA_sim_N50.csv")
+plot.data$X <- NULL
+
+q0.05.tile.plot <- ggplot(plot.data, aes(x = expr.value, y = AUC.value, fill = percent.q0.05)) +
+  geom_tile() + ng.theme + theme_light() + scale_fill_gradient2()+
+  labs(x = "Expression Value Added", y = "AUC Value Added", fill = "% q<0.05")
+ggsave(a0.05.tile.plot, file = paste0("WGV_drugSEA_sim_q0.05_N50_",Sys.Date(),".pdf"))
+
+q0.25.tile.plot <- ggplot(plot.data, aes(x = expr.value, y = AUC.value, fill = percent.q0.25)) +
+  geom_tile() + ng.theme + theme_light() + scale_fill_gradient2() + 
+  labs(x = "Expression Value Added", y = "AUC Value Added", fill = "% q<0.25")
+ggsave(q0.25.tile.plot, file = paste0("WGV_drugSEA_sim_q0.25_N50_",Sys.Date(),".pdf"))
+
+NES.tile.plot <- ggplot(plot.data, aes(x = expr.value, y = AUC.value, fill = Average.NES)) +
+  geom_tile() + ng.theme + theme_light() + scale_fill_gradient2() +
+  labs(x = "Expression Value Added", y = "AUC Value Added", fill = "Mean NES")
+ggsave(NES.tile.plot, file = paste0("WGV_drugSEA_sim_NES_N50_",Sys.Date(),".pdf"))
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diff --git a/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_interactive_network.graph.html b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
index 0000000..d83ff52
--- /dev/null
+++ b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_interactive_network.graph.html	
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
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+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
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+      cel.style.right = pad.right + "px";
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+
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+      el.style.height = px(sizing.height);
+
+      return {
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+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
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+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
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+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
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+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
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+            .css("left", el.offsetLeft)
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+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
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+              return;
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+            errorDiv
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+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
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+        }
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+    },
+    clearError: function(el) {
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+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
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+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
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+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
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+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
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+  // - renderValue (required) - A function(el, data, initValue) that will be
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+  window.HTMLWidgets.widget = function(definition) {
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+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
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+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-cd8648a27760ab985f7d" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..7b177bc
--- /dev/null
+++ b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_mean_results.csv	
@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"estrogen receptor antagonist",0.938666666666667,0.812267570484385,0.0755446994908814,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.169465136695761
+"RAF inhibitor",0.833583333333333,1.26394558702885,0.000634798367640633,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, HCC15",0.00463403912041291
+"HMGCR inhibitor",0.771583333333333,1.84500926128907,5.70283908159064e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,8,"HCC95, H1975, H1648, H2126, H520, H1299, HCC44, H1703",0.000788892739620038
+"MEK inhibitor",0.528666666666667,1.53185415477948,0.000837391696407067,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"H1650, H520, H1299, HCC44, H1703",0.00534642390782974
+"retinoid receptor agonist",0.481916666666667,1.16933076884588,0.0437670250085092,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"A549, HCC15",0.125264243989871
+"MDM inhibitor",0.4485,1.59347148190244,4.25355268913963e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,6,"H1650, HCC95, H1975, H1648, H460, A549",0.000706089746397179
+"phosphatase inhibitor",0.4395,1.07369146575558,0.248207912880679,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.420433811614211
+"FGFR inhibitor",0.387666666666667,1.281455375262,0.00664508424083666,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0290285258941812
+"TGF beta receptor inhibitor",0.358583333333333,1.21224678393119,0.0626923178535714,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.15768067823777
+"proteasome inhibitor",0.320916666666667,1.26328341729963,0.0459586121813373,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.127152160368367
+"BCL inhibitor",0.301666666666667,1.09352817923814,0.381650911659745,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.586611586439978
+"benzodiazepine receptor agonist",0.283416666666667,0.64442567218392,0.999978960984347,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"Bcr.Abl kinase inhibitor",0.259333333333333,1.20547857967722,0.107871548259925,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.213174726323185
+"dopamine receptor antagonist",0.252083333333333,0.753093916433865,0.999339740354943,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"cytochrome P450 inhibitor",0.252,1.30330984246055,0.027640697076093,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, H520",0.0943968065736886
+"sterol demethylase inhibitor",0.243083333333333,1.02981070266983,0.613435386057225,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.834674377749995
+"glutamate receptor antagonist",0.242666666666667,0.780693320456926,0.996581379921905,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"antioxidant",0.194666666666667,1.46971842283624,0.000357615200054215,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC95, H520",0.00296820616044998
+"glycogen synthase kinase inhibitor",0.17875,1.00492850265805,0.71681209770462,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.915313909376668
+"EGFR inhibitor",0.164,2.01796999707402,1.02226994967334e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,8,"H1650, HCC95, H1648, H2126, H460, H1299, HCC44, H1703",4.24242029114436e-05
+"CC chemokine receptor antagonist",0.142083333333333,1.21710277883276,0.107213326185498,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.213174726323185
+"p38 MAPK inhibitor",0.136916666666667,1.26161876235064,0.0616777878375922,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.15768067823777
+"bromodomain inhibitor",0.122583333333333,1.56627075671269,0.00228372303283276,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1975, H2126, H520, A549",0.0118468132328199
+"FLT3 inhibitor",0.117166666666667,1.22305495552834,0.10069845007875,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.213174726323185
+"acetylcholine receptor agonist",0.116416666666667,1.01375032414149,0.75980822126336,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.953314960428649
+"HDAC inhibitor",0.1095,1.15191843934763,0.239902583893652,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414831551316106
+"Abl kinase inhibitor",0.0981666666666666,1.23109048728304,0.125656508375152,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.242546283607851
+"ALK tyrosine kinase receptor inhibitor",0.0893333333333333,0.9524480738252,0.854388021410793,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"RET tyrosine kinase inhibitor",0.0759166666666666,1.13713887041384,0.374133295791199,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.585906859446594
+"KIT inhibitor",0.06825,1.05696487642684,0.655695650715209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.877786113054231
+"progesterone receptor agonist",0.0576666666666666,1.07865491434584,0.591637672409614,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.818432113499966
+"thymidylate synthase inhibitor",0.0526666666666666,1.17178367017849,0.186244240454619,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.336049390385507
+"DNA methyltransferase inhibitor",0.0505833333333332,1.30340675701886,0.028432773064364,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0943968065736886
+"adenosine receptor antagonist",0.0469166666666666,1.32520636186035,0.0390165275184611,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, H1299",0.11565613514401
+"PPAR receptor agonist",0.0341666666666667,1.26272568339887,0.104276690416759,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.213174726323185
+"PDGFR tyrosine kinase receptor inhibitor",0.0330833333333333,1.08845256783391,0.575118498540578,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.80906500642149
+"NFkB pathway inhibitor",0.0246666666666666,0.943177447233391,0.840310215094819,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"ribonucleotide reductase inhibitor",0.0115,1.4155775242892,0.00066998155957777,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.00463403912041291
+"DNA inhibitor",-0.0166666666666667,1.08916184066075,0.516155512514938,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.739773128304602
+"CHK inhibitor",-0.0320833333333334,1.2437361937714,0.0941909562139649,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.205732878046292
+"glucocorticoid receptor agonist",-0.0551666666666667,1.23375036765829,0.0729791077069916,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1648",0.169465136695761
+"acetylcholine receptor antagonist",-0.0606666666666666,1.26701541451004,0.0480719193509948,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, HCC44",0.128708687294599
+"AKT inhibitor",-0.0868333333333334,1.37173478972188,0.00902883832716294,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.0374696790577262
+"histamine receptor antagonist",-0.0944166666666667,0.64817063667095,0.999995436991143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"bacterial DNA gyrase inhibitor",-0.121666666666667,0.992845894233828,0.856983740217977,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"PI3K inhibitor",-0.13025,1.0086634833914,0.769543401791801,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.953314960428649
+"AP inhibitor",-0.137916666666667,1.44355932953197,0.0349841869698851,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, H520",0.107543982166684
+"src inhibitor",-0.138166666666667,1.58534090588705,1.08615873888801e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H1648, H1299",0.000300503917759017
+"JAK inhibitor",-0.15575,1.03324863900225,0.684255729282274,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.89465605220786
+"tyrosine kinase inhibitor",-0.163,1.0740078719874,0.516949896887553,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.739773128304602
+"adrenergic receptor agonist",-0.19025,0.877261350609228,0.96655412806198,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"opioid receptor agonist",-0.219583333333333,1.30280937406495,0.0184367518084397,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0728690666714521
+"calcium channel blocker",-0.224333333333333,0.858048455225666,0.982951592666599,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"adrenergic receptor antagonist",-0.239583333333333,0.798094031636206,0.99600164766268,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"estrogen receptor agonist",-0.247916666666667,0.863468213694405,0.974966016321922,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"protein synthesis inhibitor",-0.250833333333333,1.07899825876794,0.417290974443844,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.627257032595461
+"phosphodiesterase inhibitor",-0.25275,0.953819129509459,0.833992240948792,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"potassium channel blocker",-0.25475,1.19312219331543,0.0743316828226574,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.169465136695761
+"growth factor receptor inhibitor",-0.292666666666667,1.18552974989192,0.423209564160793,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.627257032595461
+"HCV inhibitor",-0.292833333333333,1.08417726102946,0.174514851331837,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.328305876406098
+"androgen receptor antagonist",-0.304916666666667,1.35770698795856,0.00194866276969976,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"A549, HCC15",0.0107826006590053
+"VEGFR inhibitor",-0.3315,0.79681895970506,0.991670553209632,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"mTOR inhibitor",-0.331666666666667,0.970972833000101,0.689855269172325,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.89465605220786
+"sodium channel blocker",-0.343583333333333,0.759390240837205,0.991572234561469,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"vitamin D receptor agonist",-0.352333333333333,1.5597269186002,0.00422355207943146,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, H1648, H2126, H1299",0.0194752679218228
+"MET inhibitor",-0.353666666666667,1.23811112244223,0.0748132377914362,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.169465136695761
+"DNA polymerase inhibitor",-0.373166666666667,0.784563321893527,0.974974764496359,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"PARP inhibitor",-0.376333333333333,1.24471386513552,0.0211405037498602,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0797573550562907
+"serotonin receptor antagonist",-0.41125,1.04687206173265,0.3392220471014,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.552067253125807
+"DNA alkylating agent",-0.458333333333333,1.01224892135674,0.3574509793029,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.570546755425783
+"DNA synthesis inhibitor",-0.479166666666667,1.08029969186445,0.177997161906921,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.328305876406098
+"Aurora kinase inhibitor",-0.50125,1.22597324047617,0.00288287002929136,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H520, H460",0.0140751889665402
+"protein tyrosine kinase inhibitor",-0.525416666666667,1.40441644033342,0.000155906453236167,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, HCC95, H1648, H2126",0.00177371350651608
+"CDK inhibitor",-0.52975,1.02307843163304,0.238796469601602,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414831551316106
+"cyclooxygenase inhibitor",-0.5975,0.509132506417444,0.999228103756499,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999995436991143
+"PLK inhibitor",-0.67075,1.50143126413069,9.93557130269627e-09,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, HCC95, H460, H1299",8.2465241812379e-07
+"topoisomerase inhibitor",-0.67075,1.29210308658545,0.000961733121658294,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H520, H1299, H1703",0.00570170350697417
+"tubulin polymerization inhibitor",-0.696,1.23871164742023,0.000192330380224635,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, H1299",0.00177371350651608
+"ATPase inhibitor",-0.702833333333333,1.06228115036663,0.022769525011834,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.0821682859122704
+"microtubule inhibitor",-0.7275,1.23460715135699,0.00017633888442379,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1975, H460, H1299",0.00177371350651608
+"serotonin receptor agonist",-0.857916666666667,1.24817950765638,3.16381470352771e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.000656491550982
+"bacterial 50S ribosomal subunit inhibitor",-0.96125,0.562682879362144,0.323019942674153,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.536213104839093
+"HSP inhibitor",-1.065,0.670547808613497,0.0348763103016587,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.107543982166684
diff --git a/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..d79ee1c
--- /dev/null
+++ b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_results.csv	
@@ -0,0 +1,997 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H1650","Pearson.est","EGFR inhibitor",-0.80693,-2.22,0,1340,0.0199,"AEE788, rociletinib, WZ8040, TAK.285, vandetanib, CP.724714, brigatinib, pelitinib, gefitinib, afatinib, GW.583340, ARRY.334543, erlotinib, icotinib, dacomitinib, PD.168393, BMS.599626, XL.647, tucatinib, neratinib, AZD8931, lapatinib, BMS.690514, osimertinib, canertinib, poziotinib",Inf,1.70114692359029,TRUE
+"H1650","Pearson.est","Abl kinase inhibitor",0.49473,1.18,0.276,122,0.676,"bafetinib, tozasertib, ponatinib, KW.2449, GZD824",0.559090917934782,0.170053304058364,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.63145,1.51,0.062,396,0.432,"oxiracetam, xanomeline, tremorine",1.20760831050175,0.364516253185088,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.23994,-0.661,0.862,346,1,"diphemanil, iododexetimide, hyoscyamine, dicycloverine, methscopolamine, darifenacin",0.0644927341752872,0,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",-0.41868,-1.15,0.292,1377,0.636,"theophylline, MRS.1220, CGS.15943",0.534617148551582,0.196542884351586,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.29781,-0.801,0.712,1296,0.987,"isoxsuprine, lidamidine, xylazine",0.147520006363144,0.00568284733036327,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.25222,0.624,0.891,467,1,"carvedilol, oxprenolol, idazoxan, atipamezole, atenolol......, atenolol....",0.0501222959631252,0,FALSE
+"H1650","Pearson.est","AKT inhibitor",-0.50358,-1.42,0.109,1229,0.442,"AZD5363, GSK2110183, CCT128930, triciribine, GDC.0068",0.962573502059376,0.354577730650908,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24489,-0.687,0.851,1203,1,"SB.505124, GW.788388, AP26113, brigatinib",0.0700704399154121,0,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.43636,-1.17,0.251,1250,0.667,"flutamide, RU.58841",0.600326278518962,0.175874166083451,FALSE
+"H1650","Pearson.est","antioxidant",0.4516,1.08,0.37,321,0.677,"mesna, trolox, benfotiamine",0.431798275933005,0.169411331314856,FALSE
+"H1650","Pearson.est","AP inhibitor",-0.55744,-1.53,0.079,1349,0.358,"birinapant, tanshinone.i, GDC.0152",1.10237290870956,0.446116973356126,FALSE
+"H1650","Pearson.est","ATPase inhibitor",-0.41549,-1.12,0.323,1357,0.631,"omeprazole, digitoxigenin, k.strophanthidin",0.490797477668897,0.199970640755866,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.6135,1.5,0.054,377,0.407,"tozasertib, SNS.314, KW.2449, barasertib, AMG900, AT.9283, GSK1070916, hesperadin, barasertib.HQPA, alisertib, danusertib, MK.8745, CCT137690, CCT129202, ENMD.2076",1.26760624017703,0.39040559077478,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.38406,-1.05,0.378,1249,0.709,"radezolid, tedizolid, josamycin",0.422508200162775,0.149353764816933,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.29783,0.727,0.768,374,1,"novobiocin, finafloxacin, norfloxacin",0.114638779968488,0,FALSE
+"H1650","Pearson.est","BCL inhibitor",0.45486,1.11,0.354,432,0.681,"TW.37, gossypol, ABT.737, venetoclax",0.450996737974212,0.166852888087215,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.52214,1.28,0.197,122,0.526,"bafetinib, tozasertib, ponatinib, GZD824",0.705533773838407,0.279014255846261,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",0.15989,0.384,0.999,372,0.998,"zaleplon, ZK.93423",0.000434511774017692,0.000869458712628891,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.53865,1.29,0.165,570,0.558,"bromosporine, I.BET.762, PFI.1, JQ1...., I.BET151",0.782516055786094,0.253365801062421,FALSE
+"H1650","Pearson.est","calcium channel blocker",-0.34515,-0.977,0.473,1209,0.8,"SKF.96365, SR.33805, fendiline, efonidipine.monoethanolate",0.325138859262188,0.0969100130080564,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",0.65863,1.62,0.0366,338,0.242,"SB.225002, PF.04136309, UNBS.5162, navarixin",1.43651891460559,0.616184634019569,TRUE
+"H1650","Pearson.est","CDK inhibitor",0.50274,1.21,0.244,352,0.635,"palbociclib, abemaciclib, indisulam, ribociclib, PHA.848125, dinaciclib, AZD5438, TG.02, alvocidib, P276.00, R547",0.612610173661271,0.197226274708024,FALSE
+"H1650","Pearson.est","CHK inhibitor",0.29829,0.742,0.785,753,1,"SB.218078, CHIR.124, AZD7762, PF.477736, LY2606368, SCH.900776",0.105130343254747,0,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",-0.19869,-0.551,0.965,1323,0.962,"AM.404, amfenac, FK.3311, tryptanthrin",0.0154726866562074,0.0168249279621871,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",0.40667,0.99,0.478,391,0.777,"morin, cobicistat",0.320572103387881,0.109578981199086,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.44459,1.08,0.374,437,0.677,"carmustine, melphalan, carboplatin, cyclophosphamide, TH.302, mitomycin.c, satraplatin",0.42712839779952,0.169411331314856,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.55439,1.33,0.141,160,0.595,"mechlorethamine, pibenzimol, carmustine, melphalan, carboplatin, oxaliplatin, bendamustine",0.85078088734462,0.22548303427145,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.27051,0.642,0.887,307,1,"disulfiram, fdcyd",0.0520763801682736,0,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",0.45897,1.12,0.311,326,0.683,"idoxuridine, famciclovir, trifluridine, adefovir.dipivoxil",0.507239610973163,0.165579296318467,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",0.37837,0.92,0.552,161,0.848,"floxuridine, cyclocytidine, anisomycin",0.258060922270801,0.0716041477432862,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",0.48066,1.16,0.294,328,0.667,"domperidone, amisulpride, paliperidone, sertindole, UH.232...., thioproperazine, isofloxythepin",0.531652669587843,0.175874166083451,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",-0.33895,-0.945,0.502,1325,0.809,"estradiol.cypionate, levonorgestrel",0.299296282854981,0.0920514783877277,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",0.44156,1.08,0.354,687,0.677,"toremifene, fulvestrant, danazol, raloxifene",0.450996737974212,0.169411331314856,FALSE
+"H1650","Pearson.est","FGFR inhibitor",0.56919,1.38,0.103,98,0.543,"regorafenib, dovitinib, erdafitinib",0.987162775294828,0.265200170411153,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.60291,1.47,0.0771,377,0.437,"tozasertib, dovitinib, ponatinib, KW.2449, lestaurtinib, TG.101348, TG.02, gilteritinib, sorafenib, pacritinib, ENMD.2076",1.11294562194904,0.359518563029578,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",0.19069,0.46,0.987,691,1,"prednisolone, hydrocortisone, triamcinolone, prednisolone.acetate, fluticasone.propionate, difluprednate, rimexolone, methylprednisolone, deflazacort, ciclesonide",0.00568284733036327,0,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",-0.21812,-0.575,0.934,313,0.991,"diazooxonorleucine, felbamate, SIB.1757, kynurenic.acid, CPP, JNJ.16259685, MTPG, ACDPP, IEM1754, latrepirdine, tiletamine, CGP.37849, LY456236",0.0296531237699066,0.00392634551472468,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.47378,1.14,0.302,547,0.663,"CHIR.99021, AZD2858, tideglusib, GSK.3.inhibitor.IX",0.519993057042849,0.178486471595227,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.57335,1.39,0.11,279,0.558,"GSK1838705A, lestaurtinib, PHA.848125, danusertib",0.958607314841775,0.253365801062421,FALSE
+"H1650","Pearson.est","HCV inhibitor",0.25381,0.61,0.908,1082,0.999,"mericitabine, embelin, Ro.9187, narlaprevir, daclatasvir, PSI.7976",0.0419141514789149,0.000434511774017692,FALSE
+"H1650","Pearson.est","HDAC inhibitor",0.41091,1.01,0.458,413,0.78,"resminostat, panobinostat, M.344, givinostat, PCI.24781, trichostatin.a, R306465, entinostat, nexturastat.a, vorinostat, belinostat, AR.42",0.339134521996131,0.10790539730952,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",0.20643,0.501,0.972,16,1,"pheniramine",0.0123337350737254,0,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",0.47124,1.15,0.309,239,0.664,"atorvastatin, mevastatin",0.510041520575165,0.177831920631982,FALSE
+"H1650","Pearson.est","HSP inhibitor",-0.46995,-1.26,0.203,1208,0.567,"guanidine, XL888, VER.49009, tanespimycin, alvespimycin, KW.2478",0.692503962086787,0.246416941107093,FALSE
+"H1650","Pearson.est","JAK inhibitor",0.53189,1.28,0.182,202,0.526,"atiprimod, tozasertib, lestaurtinib, TG.101348, AT.9283, AZ960, TG.02, TG.101209",0.739928612014925,0.279014255846261,FALSE
+"H1650","Pearson.est","KIT inhibitor",0.41179,1,0.461,180,0.78,"regorafenib, KI.8751, OSI.930, pazopanib",0.336299074610352,0.10790539730952,FALSE
+"H1650","Pearson.est","MDM inhibitor",0.93066,2.25,0,77,0.001,"idasanutlin, nutlin.3, AMG.232, serdemetan, CGM097",Inf,3,TRUE
+"H1650","Pearson.est","MEK inhibitor",0.77356,1.86,0.00423,228,0.0789,"cobimetinib, MEK162, AS.703026, AZD8330, selumetinib, PD.0325901, trametinib, Ro.4987655, TAK.733, PD.318088, U.0126, refametinib, PD.198306, PD.184352",2.37365963262496,1.10292299679058,TRUE
+"H1650","Pearson.est","MET inhibitor",0.3947,0.95,0.537,538,0.812,"PHA.665752, AMG458, NVP.BVU972, LY2801653",0.270025714300444,0.0904439707588247,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.28584,0.693,0.854,495,1,"vinflunine, vinblastine, D.64131, podophyllotoxin",0.068542129310995,0,FALSE
+"H1650","Pearson.est","mTOR inhibitor",-0.32115,-0.883,0.599,1155,0.88,"torin.2, NVP.BEZ235, LY3023414, GSK2126458, PI.103, deforolimus, temsirolimus, everolimus, GDC.0980, PF.05212384, sirolimus",0.222573177610689,0.0555173278498314,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",0.22361,0.535,0.96,544,1,"bortezomib, curcumin, parthenolide...., BAY.11.7082, parthenolide",0.0177287669604316,0,FALSE
+"H1650","Pearson.est","opioid receptor agonist",0.51521,1.25,0.202,329,0.568,"trimebutine, salvinorin.a",0.694648630553376,0.245651664288981,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.58534,1.4,0.116,353,0.578,"skepinone.l, SB.242235",0.935542010773082,0.238072161579471,FALSE
+"H1650","Pearson.est","PARP inhibitor",0.48205,1.16,0.311,470,0.667,"talazoparib, niraparib, AG.14361, olaparib, AZD2461",0.507239610973163,0.175874166083451,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.36518,0.886,0.612,180,0.868,"regorafenib, KI.8751, dovitinib, ponatinib, pazopanib",0.213248577854439,0.0614802748235081,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",0.53788,1.31,0.173,225,0.575,"GSK2830371, CID.5458317, sodium.stibogluconate, bis.maltolato.oxovanadium.IV.",0.761953896871205,0.24033215531037,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",0.35029,0.859,0.624,195,0.876,"anagrelide, GSK256066",0.204815410317576,0.0574958938319193,FALSE
+"H1650","Pearson.est","PI3K inhibitor",-0.24215,-0.668,0.898,1176,1,"NVP.BEZ235, LY3023414, GSK2126458, PI.103, TG100.115, CH5132799, GDC.0980, alpelisib, taselisib, PF.05212384",0.0467236633326956,0,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.76718,1.84,0.00556,227,0.0719,"rigosertib, volasertib, NMS.1286937, GSK461364",2.25492520841794,1.14327110961712,TRUE
+"H1650","Pearson.est","potassium channel blocker",0.26422,0.643,0.879,1067,1,"meglitinide, ML133, mepivacaine, ibutilide, oleoylethanolamide, dofetilide",0.0560111249262281,0,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",0.40215,0.981,0.483,524,0.774,"clofibrate, ciprofibrate, GW.501516",0.316052869248488,0.111259039317107,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",0.25694,0.617,0.899,701,1,"nomegestrol.acetate, tanaproget, norethindrone, danazol, norethindrone.acetate",0.0462403082667712,0,FALSE
+"H1650","Pearson.est","proteasome inhibitor",0.42625,1.03,0.444,402,0.761,"bortezomib, ixazomib, MG.132",0.35261702988538,0.118615343229427,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.3727,0.906,0.591,145,0.854,"brefeldin.a, homoharringtonine, cycloheximide",0.228412519118745,0.068542129310995,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",-0.63167,-1.71,0.0407,1317,0.232,"AV.412, mubritinib, CP.724714, BMS.599626",1.39040559077478,0.6345120151091,TRUE
+"H1650","Pearson.est","RAF inhibitor",0.85831,2.06,0,51,0.00752,"dabrafenib, AZ.628, vemurafenib, regorafenib, TAK.632, GDC.0879, SB.590885, LGX818, CEP.32496",Inf,2.12378215940836,TRUE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.36771,0.878,0.615,19,0.863,"regorafenib",0.211124884224583,0.0639892042847904,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.26604,0.651,0.881,609,1,"tamibarotene, adarotene, CD.437, fenretinide, bexarotene",0.0550240915879521,0,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.73194,1.75,0.00823,222,0.127,"cladribine, clofarabine, triapine, LY2334737, fludarabine.phosphate, fludarabine, pentostatin",2.08460016478773,0.896196279044043,TRUE
+"H1650","Pearson.est","serotonin receptor agonist",0.29702,0.715,0.827,686,1,"NAN.190, zolmitriptan, SR.57227A, aripiprazole",0.0824944904474534,0,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",0.55486,1.33,0.15,251,0.595,"pirenperone, lerisetron, paliperidone, SB.200646, SB.216641, sertindole",0.823908740944319,0.22548303427145,FALSE
+"H1650","Pearson.est","sodium channel blocker",0.19405,0.47,0.989,408,1,"mexiletine, quinidine, ajmaline, benzethonium",0.0048037084028206,0,FALSE
+"H1650","Pearson.est","src inhibitor",-0.63439,-1.73,0.0177,1387,0.285,"bosutinib, dasatinib, ZM.306416, saracatinib",1.75202673363819,0.54515513999149,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",0.29869,0.73,0.802,424,1,"posaconazole, chlormidazole",0.0958256317158365,0,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.49787,-1.39,0.135,1054,0.422,"SB.431542, D.4476, LY2109761, repsox",0.869666231504994,0.374687549038326,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.69187,1.68,0.0161,196,0.187,"carmofur, raltitrexed, trifluridine",1.79317412396815,0.728158393463501,TRUE
+"H1650","Pearson.est","topoisomerase inhibitor",0.53856,1.31,0.159,577,0.575,"topotecan, nemorubicin, amsacrine, teniposide, daunorubicin, doxorubicin, voreloxin, etoposide.phosphate, rubitecan, valrubicin, idarubicin, TAS.103, irinotecan, SN.38, fleroxacin, amonafide, exatecan.mesylate, genz.644282",0.798602875679548,0.24033215531037,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.5329,1.3,0.167,600,0.566,"verubulin, albendazole, fosbretabulin, indibulin, taltobulin, vindesine, BNC105, vinblastine, combretastatin.A.4, oxibendazole, vincristine, parbendazole, vinorelbine, CYT.997, podophyllotoxin, nocodazole, dolastatin.10, KX2.391, ABT.751, plinabulin, fenbendazole",0.777283528852417,0.247183568811729,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",-0.2925,-0.797,0.703,1317,0.936,"AV.412, mubritinib, vandetanib, CP.724714, dasatinib, BMS.599626",0.153044674980176,0.0287241512618947,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",-0.24596,-0.659,0.874,1307,0.954,"linifanib, MGCD.265, AEE788, vandetanib, ZM.306416, XL.647, BMS.690514",0.058488567365597,0.0204516252959049,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.81696,-2.22,0,1277,0.0199,"paricalcitol, ercalcitriol, calcitriol, tacalcitol, maxacalcitol",Inf,1.70114692359029,TRUE
+"HCC95","Pearson.est","EGFR inhibitor",-0.82258,-1.99,0,1339,0.0352,"GW.583340, TAK.285, CNX.2006, CUDC.101, PD.168393, brigatinib, WZ8040, WZ.3146, BMS.599626, AST.1306, icotinib, BIBX.1382, WZ.4002, ARRY.334543, CP.724714, AEE788, rociletinib, BMS.690514, tucatinib, pelitinib, neratinib, lapatinib, AZD8931, osimertinib, dacomitinib, erlotinib, canertinib, XL.647, gefitinib, afatinib, poziotinib",Inf,1.45345733652187,TRUE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.40989,-0.962,0.504,1397,0.833,"bosutinib, ZM.306416",0.297569463554475,0.0793549985932124,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.39656,1.08,0.348,504,0.512,"nefiracetam, tremorine, oxiracetam, nicotine, pilocarpine",0.458420756053419,0.290730039024169,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",0.4861,1.34,0.168,15,0.341,"iododexetimide",0.774690718274137,0.467245621007502,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",-0.55151,-1.3,0.172,1441,0.491,"CGS.15943",0.764471553092451,0.308918507877032,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",0.33077,0.905,0.518,974,0.716,"ritodrine, isoxsuprine, isoetharine, xylazine, norepinephrine, epinephrine, oxymetazoline, metaraminol, methyldopa, terbutaline, buphenine, lidamidine, midodrine, A61603, clenbuterol",0.285670240254767,0.145086977692144,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",-0.28586,-0.702,0.82,807,0.993,"atenolol......, prazosin, idazoxan, dronedarone, practolol, dihydroergocristine, carvedilol, RS.17053, vincamine, imiloxan",0.0861861476162833,0.00305075150461883,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.60449,-1.45,0.0873,1313,0.425,"CCT128930, GDC.0068, triciribine, uprosertib",1.05898575629443,0.371611069949688,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.6994,-1.64,0.0242,1232,0.281,"NVP.TAE684, CEP.37440, alectinib, SB.505124, brigatinib, AZD3463",1.61618463401957,0.55129368009492,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",0.64869,1.75,0.0534,368,0.192,"bicalutamide, enzalutamide, flutamide",1.27245874297144,0.71669877129645,FALSE
+"HCC95","Pearson.est","antioxidant",0.64578,1.77,0.0208,117,0.22,"benfotiamine, trolox, chlorogenic.acid",1.68193666503724,0.657577319177794,TRUE
+"HCC95","Pearson.est","AP inhibitor",0.45306,1.25,0.238,313,0.365,"idronoxil, birinapant, GDC.0152",0.623423042943488,0.437707135543525,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",-0.47937,-1.13,0.32,1039,0.637,"digoxin, digitoxigenin, evodiamine, oligomycin.a, rabeprazole, NMS.873, k.strophanthidin",0.494850021680094,0.19586056766465,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",-0.65237,-1.56,0.0538,961,0.308,"AMG900, SNS.314, AT.9283, barasertib, aurora.a.inhibitor.i, CCT137690, PF.03814735, MK.5108, GSK1070916, alisertib, ENMD.2076, hesperadin, MK.8745, MLN.8054, ZM.447439, CCT129202, TAK.901, barasertib.HQPA, danusertib, CYC116, PHA.680632",1.26921772433361,0.511449283499556,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.63074,-1.51,0.0637,1146,0.374,"valnemulin, tedizolid, azithromycin, radezolid",1.19586056766465,0.42712839779952,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.54674,1.5,0.108,135,0.258,"nadifloxacin, sparfloxacin, novobiocin",0.96657624451305,0.58838029403677,FALSE
+"HCC95","Pearson.est","BCL inhibitor",0.57806,1.58,0.062,274,0.278,"oridonin, ABT.737, venetoclax, navitoclax",1.20760831050175,0.555955204081924,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.2711,-0.645,0.881,1227,1,"metatinib, bosutinib",0.0550240915879521,0,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.21704,-0.519,0.967,1058,1,"ZK.93423, bentazepam, ivermectin",0.0145735259169983,0,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",-0.51158,-1.23,0.223,1037,0.533,"I.BET151, JQ1...., OTX015, I.BET.762",0.651695136951839,0.273272790973428,FALSE
+"HCC95","Pearson.est","calcium channel blocker",-0.43596,-1.03,0.413,840,0.723,"mibefradil, fendiline, tetrandrine, carboxyamidotriazole, efonidipine.monoethanolate, penfluridol",0.384049948343599,0.140861702705469,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.25263,-0.594,0.937,980,1,"MK.0812, SB.225002, ZK811752",0.0282604091122217,0,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.59551,-1.42,0.115,1022,0.417,"dinaciclib, ribociclib, palbociclib, PHA.848125, alvocidib, TG.02, R547, aminopurvalanol.a, arcyriaflavin.a, indisulam, JNJ.7706621, BMS.265246, PHA.793887, AT.7519, BMS.387032",0.939302159646388,0.379863945026242,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.38498,-0.924,0.561,1088,0.857,"LY2603618, SB.218078",0.251037138743839,0.0670191780768018,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.2133,-0.518,0.976,839,1,"curcumin, indoprofen, phenazone, aspirin, piroxicam, FK.3311, FR.122047, ramifenazone, amfenac, tryptanthrin",0.0105501823333082,0,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.57248,1.54,0.0797,206,0.282,"metyrapone, clotrimazole, morin",1.09854167860389,0.549750891680639,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.29434,-0.708,0.815,1073,1,"cyclophosphamide, mitomycin.c, estramustine, dacarbazine",0.0888423912600234,0,FALSE
+"HCC95","Pearson.est","DNA inhibitor",0.3543,0.936,0.511,193,0.73,"nimorazole, carboplatin, pibenzimol, bendamustine, metronidazole, nithiamide",0.291579099865287,0.136677139879544,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.66795,-1.59,0.0352,1132,0.288,"fdcyd, SGI.1027, azacitidine, decitabine",1.45345733652187,0.540607512240769,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",-0.30702,-0.742,0.8,918,1,"idoxuridine, trifluridine, cidofovir, cephalomannine",0.0969100130080564,0,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.39352,-0.951,0.528,1191,0.829,"mitomycin.c, cyclocytidine, anisomycin, enocitabine",0.277366077466188,0.0814454694497265,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",0.20647,0.564,0.959,125,0.989,"amisulpride, clebopride, ziprasidone",0.0181813928293364,0.0048037084028206,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.3294,-0.769,0.744,1351,1,"levonorgestrel",0.128427064454121,0,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",0.49537,1.4,0.0819,47,0.302,"danazol, toremifene",1.08671609823958,0.519993057042849,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",0.3212,0.848,0.576,250,0.75,"erdafitinib, orantinib, dovitinib",0.239577516576788,0.1249387366083,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",-0.15575,-0.367,0.999,1100,0.999,"TG.02, ENMD.2076, pacritinib",0.000434511774017692,0.000434511774017692,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.52912,-1.25,0.212,1030,0.517,"betamethasone, rimexolone, desonide, methylprednisolone, difluprednate, deflazacort, beclomethasone.dipropionate, halcinonide, clobetasol.propionate, flumethasone.pivalate, triamcinolone.acetonide, halobetasol.propionate, fluorometholone, flumethasone, ciclesonide",0.673664139071249,0.286509456906058,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",-0.15638,-0.372,0.999,893,1,"CPP, SIB.1757, CGP.37849, LY456236",0.000434511774017692,0,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.70409,1.91,0.0148,167,0.141,"CHIR.98014, CHIR.99021, GSK.3.inhibitor.IX, tideglusib, LY2090314",1.82973828460504,0.85078088734462,TRUE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.57559,-1.35,0.145,863,0.469,"lestaurtinib, GSK1904529A, PHA.848125, GSK1838705A, danusertib, AZD3463",0.838631997765025,0.328827157284917,FALSE
+"HCC95","Pearson.est","HCV inhibitor",-0.30609,-0.734,0.783,994,1,"PSI.7976, narlaprevir",0.106238237942057,0,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.35522,-0.84,0.659,793,0.993,"resminostat, romidepsin, R306465, chidamide, RGFP966, M.344, ACY.1215, belinostat, NSC.3852, trichostatin.a, AR.42, scriptaid, vorinostat, givinostat, PCI.24781, JNJ.26481585, SB.939, dacinostat",0.18111458540599,0.00305075150461883,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",0.14755,0.409,1,1237,0.999,"epinastine, lafutidine, chloropyramine, famotidine, nizatidine, ICI.162846, cimetidine, tecastemizole, cyproheptadine, astemizole, pheniramine, ranitidine, tiotidine, BF2.649, zolantidine, terfenadine, levocetirizine, ebastine",0,0.000434511774017692,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.92748,2.54,0,10,0.00125,"pitavastatin, fluvastatin, lovastatin, mevastatin, atorvastatin",Inf,2.90308998699194,TRUE
+"HCC95","Pearson.est","HSP inhibitor",-0.55835,-1.31,0.164,1012,0.499,"ganetespib, VER.49009, alvespimycin, NVP.AUY922, KW.2478, BIIB021, PU.H71, tanespimycin",0.785156151952302,0.30189945437661,FALSE
+"HCC95","Pearson.est","JAK inhibitor",-0.54278,-1.28,0.206,863,0.507,"lestaurtinib, CEP.33779, ruxolitinib, AT.9283, baricitinib, LY2784544, TG.02, AZD1480, WHI.P154, AZ960, PRT062070, pacritinib, filgotinib",0.686132779630847,0.294992040666664,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.15802,-0.38,0.999,876,1,"lenvatinib, imatinib, cediranib, vatalanib, OSI.930",0.000434511774017692,0,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.81246,2.28,0,98,0.00939,"AMG.232, idasanutlin, CGM097, nutlin.3",Inf,2.02733440773389,TRUE
+"HCC95","Pearson.est","MEK inhibitor",0.27506,0.761,0.734,290,0.864,"BIX.02188, U.0126, refametinib, cobimetinib, MEK1.2.inhibitor",0.134303940083929,0.0634862575211067,FALSE
+"HCC95","Pearson.est","MET inhibitor",0.61519,1.69,0.0563,187,0.212,"NVP.BVU972, AMG458, PHA.665752",1.24949160514865,0.673664139071249,FALSE
+"HCC95","Pearson.est","microtubule inhibitor",-0.59401,-1.42,0.0886,1168,0.417,"colchicine, podophyllotoxin, vinflunine, cabazitaxel, D.64131",1.05256627811295,0.379863945026242,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.4901,-1.17,0.279,1057,0.632,"AZD2014, torin.2, deforolimus, MLN0128, torin.1, PP242, WYE.125132, PI.103, AZD8055, GDC.0980, GSK2126458, WYE.354, PF.05212384",0.554395796726402,0.199282921717615,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",-0.29437,-0.682,0.838,839,0.997,"curcumin, parthenolide...., IKK.2.inhibitor.V, parthenolide, Ro.106.9920, EVP4593",0.0767559813697235,0.00130484168834428,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",0.48571,1.33,0.135,121,0.328,"BW.180C, ADL5859",0.869666231504994,0.484126156288321,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",-0.59319,-1.41,0.104,1237,0.406,"CMPD.1, SB.239063, talmapimod",0.98296666070122,0.391473966422806,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.30692,-0.732,0.792,809,0.998,"endo.IWR.1, olaparib, AZD2461, PJ.34, niraparib, talazoparib",0.101274818410506,0.000869458712628891,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.25136,0.686,0.871,474,0.939,"orantinib, KI.8751, ponatinib, linifanib, dovitinib, pazopanib, telatinib, trapidil, regorafenib, tandutinib, nintedanib, masitinib, CP.673451",0.0599818449923368,0.0273344077338891,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.46615,1.29,0.192,236,0.344,"bis.maltolato.oxovanadium.IV., BVT.948, GSK2830371, menadione, CID.5458317",0.71669877129645,0.46344155742847,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.40609,1.08,0.325,79,0.512,"anagrelide, enoximone, GSK256066",0.488116639021126,0.290730039024169,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.47691,-1.13,0.341,1184,0.637,"PI.103, PIK.75, TG.100713, GDC.0980, CH5132799, GSK2126458, PF.05212384, alpelisib, taselisib",0.467245621007502,0.19586056766465,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.78624,-1.89,0.00418,1195,0.079,"rigosertib, HMN.214, GW.843682X, BI.2536, volasertib, NMS.1286937",2.37882371822496,1.10237290870956,TRUE
+"HCC95","Pearson.est","potassium channel blocker",0.34357,0.927,0.561,231,0.711,"meglitinide, ML133",0.251037138743839,0.148130399270234,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.51159,1.43,0.101,124,0.298,"fenofibrate, clofibrate, S26948",0.995678626217357,0.525783735923745,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",0.55773,1.53,0.0931,166,0.259,"norethindrone, danazol, nomegestrol.acetate, norethindrone.acetate, norgestrel",1.03105031901866,0.586700235918748,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",-0.46498,-1.1,0.348,1201,0.649,"carfilzomib",0.458420756053419,0.187755303199631,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",-0.52955,-1.25,0.22,1054,0.517,"chloramphenicol.palmitate, emetine, thiostrepton, anguidine, cycloheximide, harringtonine, puromycin, homoharringtonine, tedizolid.phosphate, bruceantin",0.657577319177794,0.286509456906058,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.73593,-1.77,0.0111,1400,0.124,"BMS.599626, NVP.TAE226, CP.724714, AV.412",1.95467702121334,0.906578314837765,TRUE
+"HCC95","Pearson.est","RAF inhibitor",0.43855,1.22,0.234,58,0.376,"dabrafenib, vemurafenib",0.630784142589857,0.424812155072339,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.4612,-1.1,0.351,1049,0.649,"cabozantinib, vandetanib",0.454692883534176,0.187755303199631,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.34089,-0.823,0.678,898,0.998,"bexarotene, adapalene, tamibarotene, adarotene, CD.437",0.168770306132937,0.000869458712628891,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.33818,0.9,0.54,211,0.693,"pentostatin, hydroxyurea, fludarabine",0.267606240177031,0.159266765388193,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.62769,-1.47,0.0785,1229,0.417,"zolmitriptan, pardoprunox, aripiprazole",1.10513034325475,0.379863945026242,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",-0.31242,-0.742,0.788,1061,1,"sertindole, RS.16566, SB.228357, aripiprazole",0.103473782510445,0,FALSE
+"HCC95","Pearson.est","sodium channel blocker",-0.23778,-0.562,0.942,1094,1,"lappaconite, benzethonium, A.803467, brivaracetam",0.0259490972071227,0,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.76153,-1.82,0.00821,1397,0.107,"bosutinib, saracatinib, ZM.306416",2.08565684288056,0.97061622231479,TRUE
+"HCC95","Pearson.est","sterol demethylase inhibitor",0.23786,0.665,0.885,1105,0.931,"posaconazole, terconazole, chlormidazole, ketoconazole, sulconazole, lanoconazole",0.0530567293021746,0.0310503190186574,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.55703,-1.31,0.166,960,0.499,"SB.525334, adaprev, D.4476, repsox",0.779891911959945,0.30189945437661,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.32746,-0.787,0.711,1338,1,"carmofur",0.148130399270234,0,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",-0.43831,-1.05,0.41,816,0.729,"valrubicin, licochalcone.a, teniposide, daunorubicin, etoposide, beta.lapachone, idarubicin, irinotecan, amsacrine, TAS.103, mitoxantrone, genz.644282, amonafide, camptothecin, SN.38, exatecan.mesylate, dexrazoxane",0.387216143280265,0.137272471682025,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.67484,-1.62,0.0288,1121,0.272,"combretastatin.A.4, flubendazole, podophyllotoxin, CYT.997, indibulin, mebendazole, vincristine, fenbendazole, taltobulin, albendazole, dolastatin.10, plinabulin, fosbretabulin, nocodazole, ABT.751, vinorelbine, epothilone.b, parbendazole, paclitaxel, docetaxel",1.54060751224077,0.565431095965801,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.48879,-1.14,0.318,1314,0.667,"vandetanib, BMS.599626, NVP.TAE226, CP.724714, AV.412, tivantinib",0.497572880015567,0.175874166083451,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.44053,-1.03,0.43,1010,0.723,"golvatinib, semaxanib, cabozantinib, cediranib, SU014813, vatalanib, PD.173074, ENMD.2076, lucitanib, OSI.930, vandetanib, AEE788, ZM.306416, BMS.690514, XL.647",0.366531544420413,0.140861702705469,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",-0.5881,-1.4,0.112,913,0.398,"doxercalciferol, calcitriol, ercalcitriol, paricalcitol, tacalcitol, maxacalcitol",0.950781977329818,0.400116927926312,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.70857,1.73,0.00972,249,0.295,"neratinib, AZD8931, AST.1306, gefitinib, poziotinib, erlotinib, afatinib, tucatinib, dacomitinib, CUDC.101, lapatinib, pelitinib, XL.647, BIBU.1361, BMS.690514, ARRY.334543, osimertinib, dovitinib, BIBX.1382, canertinib, AEE788, WZ.4002, CNX.2006, CP.724714, WZ.3146, vandetanib",2.01233373507373,0.530177984021837,FALSE
+"H1975","Pearson.est","Abl kinase inhibitor",0.48988,1.22,0.242,98,0.597,"ZM.306416, bafetinib",0.616184634019569,0.224025668870631,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",0.36708,0.913,0.573,505,0.725,"xanomeline, pilocarpine, tremorine, oxiracetam",0.24184537803261,0.139661993429006,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",-0.63911,-1.78,0.0257,1277,0.163,"methscopolamine, iododexetimide",1.59006687666871,0.787812395596042,TRUE
+"H1975","Pearson.est","adenosine receptor antagonist",0.44599,1.1,0.345,444,0.613,"CGS.15943, MRS.1220, istradefylline, sulmazole, PSB.1115, SCH.58261",0.462180904926726,0.212539525481585,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",-0.56444,-1.54,0.0838,1086,0.275,"ritodrine, buphenine, epinephrine, A61603, clenbuterol, norepinephrine, isoxsuprine, midodrine, lidamidine, xylazine",1.07675598136972,0.560667306169737,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.28701,0.715,0.804,42,0.9,"atenolol......, dihydroergocristine",0.0947439512515487,0.0457574905606751,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.41933,1.03,0.406,445,0.646,"uprosertib, GDC.0068, GSK2110183, A.674563, triciribine, palomid.529",0.391473966422806,0.189767482004916,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.46751,1.16,0.27,518,0.598,"alectinib, CEP.37440, NVP.TAE684, crizotinib, DMH1, brigatinib, SB.505124, AZD3463",0.568636235841013,0.223298816011589,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",-0.43961,-1.18,0.272,940,0.476,"RU.58841, bicalutamide, cyproterone.acetate, flutamide, enzalutamide",0.565431095965801,0.322393047279507,FALSE
+"H1975","Pearson.est","antioxidant",-0.58277,-1.55,0.0962,1076,0.294,"benfotiamine, chlorogenic.acid, taurine, rutin",1.01682492796219,0.531652669587843,FALSE
+"H1975","Pearson.est","AP inhibitor",-0.91447,-2.44,0,1431,0,"LCL.161, GDC.0152, birinapant",Inf,Inf,TRUE
+"H1975","Pearson.est","ATPase inhibitor",-0.44021,-1.19,0.243,1216,0.514,"omeprazole, digitoxin, blebbistatin...., digitoxigenin, ouabain",0.614393726401688,0.289036881004724,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",0.3713,0.916,0.549,276,0.74,"ENMD.2076, CCT137690, PHA.680632, danusertib, barasertib.HQPA, hesperadin",0.260427655549908,0.130768280269024,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.28974,-0.776,0.739,1157,0.863,"tedizolid, josamycin, dirithromycin",0.131355561605174,0.0639892042847904,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.46848,-1.27,0.193,1340,0.492,"sarafloxacin, sparfloxacin",0.714442690992226,0.30803489723264,FALSE
+"H1975","Pearson.est","BCL inhibitor",0.48751,1.21,0.25,219,0.585,"TW.37, obatoclax, gossypol",0.602059991327962,0.23284413391782,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",0.32739,0.814,0.679,98,0.824,"bafetinib",0.168130225719498,0.0840727883028842,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",-0.27776,-0.718,0.804,1217,0.869,"nefiracetam, lorazepam, indiplon, CGS.20625",0.0947439512515487,0.0609802235513335,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",0.76144,1.88,0.0031,350,0.125,"I.BET151, JQ1...., bromosporine, OTX015, I.BET.762, PFI.1",2.50863830616573,0.903089986991944,TRUE
+"H1975","Pearson.est","calcium channel blocker",0.34357,0.859,0.633,335,0.775,"tetrandrine, cinnarazine, mibefradil",0.198596289982645,0.11069829749369,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",0.38259,0.954,0.511,462,0.695,"ZK811752, UNBS.5162, SB.225002",0.291579099865287,0.158015195409886,FALSE
+"H1975","Pearson.est","CDK inhibitor",0.4781,1.17,0.281,442,0.605,"TG.02, R547, P276.00, indisulam, indirubin, ribociclib, arcyriaflavin.a, abemaciclib, PHA.848125, NU6027, JNJ.7706621",0.55129368009492,0.218244625347531,FALSE
+"H1975","Pearson.est","CHK inhibitor",0.59221,1.47,0.0837,384,0.514,"AZD7762, PF.477736, SB.218078, CHIR.124",1.07727454200674,0.289036881004724,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.29134,-0.776,0.71,1178,0.863,"AM.404, phenylbutazone, indoprofen, amfenac, acetylsalicylsalicylic.acid, suxibuzone, metoxibutropate",0.148741651280925,0.0639892042847904,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.64187,-1.77,0.0279,1118,0.15,"morin, eplerenone, clotrimazole",1.5543957967264,0.823908740944319,TRUE
+"H1975","Pearson.est","DNA alkylating agent",-0.2485,-0.675,0.851,1235,0.873,"carboplatin, streptozotocin, cisplatin",0.0700704399154121,0.0589857562944303,FALSE
+"H1975","Pearson.est","DNA inhibitor",0.39292,0.967,0.502,488,0.692,"mechlorethamine, bendamustine, valrubicin, oxaliplatin, nimorazole, nithiamide, melphalan",0.299296282854981,0.159893905543242,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.57599,1.46,0.109,267,0.478,"fdcyd, disulfiram, azacitidine",0.962573502059376,0.320572103387881,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",-0.30178,-0.807,0.642,1319,0.872,"foscarnet, cephalomannine",0.192464971931147,0.0594835150674328,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",-0.34883,-0.954,0.466,1432,0.729,"cisplatin, altretamine",0.33161408331,0.137272471682025,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",0.28061,0.705,0.82,164,0.836,"mesoridazine, sertindole, domperidone",0.0861861476162833,0.0777937225609836,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.275,-0.747,0.759,1242,0.882,"estradiol.cypionate, estradiol",0.11975822410452,0.0545314148681803,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",0.44179,1.11,0.342,45,0.642,"clomifene",0.465973893943865,0.192464971931147,FALSE
+"H1975","Pearson.est","FGFR inhibitor",0.50863,1.28,0.192,112,0.506,"regorafenib, dovitinib",0.71669877129645,0.295849483160201,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",0.55149,1.38,0.136,236,0.477,"pacritinib, TG.02, ENMD.2076, dovitinib, sorafenib, TG.101348",0.866461091629782,0.321481620959886,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",0.65972,1.63,0.0382,297,0.342,"hydrocortisone, ciclesonide, difluprednate, triamcinolone.acetonide, desonide, rimexolone, methylprednisolone, deflazacort, halobetasol.propionate, halcinonide, triamcinolone, fludroxycortide, beclomethasone.dipropionate, prednisolone.acetate, clobetasol.propionate, prednisolone, flumethasone.pivalate",1.41793663708829,0.465973893943865,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",0.28824,0.709,0.807,111,0.849,"CPP, CGP.37849",0.0931264652779296,0.0710923097560473,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.41589,-1.1,0.325,1334,0.542,"tideglusib, CHIR.98014",0.488116639021126,0.266000713461613,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",0.48444,1.19,0.232,518,0.596,"danusertib, GSK1838705A, PHA.848125, lestaurtinib, AZD3463",0.6345120151091,0.224753740259764,FALSE
+"H1975","Pearson.est","HCV inhibitor",-0.42954,-1.16,0.279,932,0.478,"mericitabine, daclatasvir, narlaprevir, PSI.7976",0.554395796726402,0.320572103387881,FALSE
+"H1975","Pearson.est","HDAC inhibitor",0.55686,1.38,0.116,394,0.477,"PCI.24781, M.344, givinostat, scriptaid, vorinostat, R306465, trichostatin.a, NSC.3852, RGFP966, AR.42, SB.939, resminostat, dacinostat, ACY.1215, belinostat, nexturastat.a",0.935542010773082,0.321481620959886,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",-0.469,-1.28,0.187,1264,0.512,"nizatidine, ebastine, lafutidine, zolantidine, tiotidine, cimetidine, chloropyramine",0.728158393463501,0.290730039024169,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.80608,-2.1,0.00565,1397,0.0581,"pitavastatin, mevastatin, fluvastatin",2.24795155218056,1.23582386760967,TRUE
+"H1975","Pearson.est","HSP inhibitor",-0.6217,-1.71,0.0488,1022,0.176,"XL888, VER.49009, guanidine, ganetespib, KW.2478, BIIB021, NVP.AUY922, PU.H71, alvespimycin",1.31158017799729,0.75448733218585,TRUE
+"H1975","Pearson.est","JAK inhibitor",0.44456,1.11,0.336,41,0.642,"atiprimod, pacritinib, TG.02, AZ960",0.473660722610156,0.192464971931147,FALSE
+"H1975","Pearson.est","KIT inhibitor",0.34818,0.864,0.625,61,0.787,"OSI.930, regorafenib",0.204119982655925,0.104025267640935,FALSE
+"H1975","Pearson.est","MDM inhibitor",0.81415,2.02,0.00152,274,0.0524,"idasanutlin, nutlin.3, RITA, CGM097, AMG.232, serdemetan",2.81815641205523,1.28066871301627,TRUE
+"H1975","Pearson.est","MEK inhibitor",0.4434,1.09,0.353,508,0.607,"cobimetinib, AS.703026, trametinib, PD.0325901, selumetinib, MEK162, AZD8330, MEK1.2.inhibitor, Ro.4987655, PD.198306, TAK.733, U.0126",0.452225294612177,0.216811308924742,FALSE
+"H1975","Pearson.est","MET inhibitor",-0.72939,-2.01,0.0139,1404,0.0851,"PF.04217903, LY2801653",1.8569851997459,1.07007043991541,TRUE
+"H1975","Pearson.est","microtubule inhibitor",-0.6915,-1.89,0.0131,1328,0.111,"cabazitaxel, vinblastine, cytochalasin.b",1.88272870434424,0.954677021213343,TRUE
+"H1975","Pearson.est","mTOR inhibitor",0.52818,1.31,0.167,454,0.545,"GSK2126458, WAY.600, WYE.125132, voxtalisib, XL388, PP242, AZD8055, torin.2, AZD2014, GDC.0980, OSI.027, PF.04691502, WYE.354, LY303511, palomid.529, PKI.179",0.777283528852417,0.263603497723358,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",0.16239,0.408,0.997,264,0.997,"EVP4593, curcumin",0.00130484168834428,0.00130484168834428,FALSE
+"H1975","Pearson.est","opioid receptor agonist",-0.56681,-1.53,0.0769,1270,0.258,"ADL5859, BW.180C, spiradoline",1.11407366019857,0.58838029403677,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",0.57292,1.42,0.126,328,0.476,"SB.242235, talmapimod, skepinone.l, CMPD.1",0.899629454882437,0.322393047279507,FALSE
+"H1975","Pearson.est","PARP inhibitor",-0.28559,-0.744,0.718,1266,0.859,"olaparib, E7449",0.1438755557577,0.0660068361687577,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30189,-0.814,0.649,1387,0.892,"linifanib, SU014813, CP.673451",0.187755303199631,0.0496351456238769,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",0.41646,1.02,0.441,330,0.642,"mycophenolate.mofetil, alexidine, mycophenolic.acid, CID.5458317",0.355561410532161,0.192464971931147,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",-0.31464,-0.858,0.62,1148,0.842,"EMD.53998, zardaverine, GSK256066, YM.976",0.207608310501746,0.0746879085003505,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.52651,1.31,0.169,454,0.545,"GSK2126458, taselisib, YM.201636, PI3K.IN.2, alpelisib, GDC.0941, voxtalisib, CUDC.907, CH5132799, buparlisib, PI.828, GDC.0980, BGT226, PF.04691502, PIK.75, pilaralisib, LY303511, PKI.179",0.772113295386326,0.263603497723358,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.28684,0.711,0.813,208,0.865,"NMS.1286937",0.0899094544059319,0.0629838925351858,FALSE
+"H1975","Pearson.est","potassium channel blocker",-0.45178,-1.22,0.248,1138,0.501,"meglitinide, mepivacaine, dofetilide",0.605548319173784,0.300162274132754,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",-0.51554,-1.38,0.158,1282,0.406,"clofibrate, S26948, fenofibrate",0.801342913045577,0.391473966422806,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.43137,-1.18,0.236,1349,0.476,"norgestrel, dienogest",0.627087997029893,0.322393047279507,FALSE
+"H1975","Pearson.est","proteasome inhibitor",-0.44693,-1.22,0.239,1312,0.501,"ONX.0914, delanzomib",0.621602099051862,0.300162274132754,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.4036,0.998,0.456,441,0.66,"azomycin..2.nitroimidazole., brefeldin.a, cycloheximide, clindamycin.phosphate, homoharringtonine, anguidine, bruceantin, thiostrepton, clofoctol",0.341035157335565,0.180456064458131,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.58408,1.45,0.0787,316,0.453,"NVP.TAE226, tyrphostin.A9, CP.724714, AV.412, BMS.599626",1.10402526764094,0.343901797987168,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.66789,1.67,0.0321,338,0.335,"SB.590885, regorafenib, AZ.628, CEP.32496, sorafenib, TAK.632, LGX818, dabrafenib",1.49349496759513,0.474955192963155,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.62506,1.55,0.0641,249,0.454,"regorafenib, sorafenib, vandetanib",1.19314197048118,0.342944147142896,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.5109,1.28,0.186,346,0.506,"CD.437, fenretinide, tamibarotene, adarotene, bexarotene",0.730487055782084,0.295849483160201,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.4279,1.08,0.365,269,0.603,"cytarabine, fludarabine.phosphate, pentostatin",0.437707135543525,0.219682687859849,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.74427,-1.98,0.00289,1272,0.0784,"SR.57227A, pardoprunox, ipsapirone, aripiprazole",2.53910215724345,1.10568393731556,TRUE
+"H1975","Pearson.est","serotonin receptor antagonist",-0.35201,-0.943,0.475,1447,0.718,"aripiprazole",0.323306390375133,0.1438755557577,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.25186,-0.687,0.859,1141,0.884,"lappaconite, mepivacaine, brivaracetam, cibenzoline",0.0660068361687577,0.0535477349869269,FALSE
+"H1975","Pearson.est","src inhibitor",0.32452,0.812,0.711,96,0.807,"ZM.306416",0.148130399270234,0.0931264652779296,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",0.30121,0.739,0.777,591,0.891,"posaconazole, lanoconazole, sulconazole",0.109578981199086,0.0501222959631252,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.4375,1.06,0.386,354,0.616,"SB.525334, D.4476, SB.431542",0.413412695328245,0.210419287835575,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.28819,0.711,0.811,521,0.865,"carmofur, raltitrexed, trifluridine",0.090979145788844,0.0629838925351858,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",-0.21785,-0.599,0.947,310,0.927,"valrubicin, amsacrine, nemorubicin, idarubicin, voreloxin, SN.38, beta.lapachone, doxorubicin, dexrazoxane, exatecan.mesylate, topotecan, teniposide, TAS.103, mitoxantrone, camptothecin, licochalcone.a, epirubicin, amonafide, daunorubicin, irinotecan, rubitecan, etoposide, etoposide.phosphate, genz.644282, fleroxacin",0.0236500209967266,0.0329202658555029,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",-0.38131,-1.05,0.379,1144,0.591,"vindesine, dolastatin.10, verubulin, epothilone.b, epothilone.d, vinblastine, paclitaxel, docetaxel, BNC105",0.421360790031928,0.228412519118745,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",0.52909,1.3,0.165,316,0.53,"regorafenib, hypericin, bafetinib, NVP.TAE226, tyrphostin.A9, CP.724714, AV.412, sorafenib, vandetanib, BMS.599626",0.782516055786094,0.275724130399211,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",0.44578,1.1,0.346,249,0.613,"OSI.930, ENMD.2076, XL.647, regorafenib, BMS.690514, ZM.306416, golvatinib, dovitinib, AEE788, sorafenib, vandetanib",0.460923901207223,0.212539525481585,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.59868,1.47,0.0929,477,0.514,"tacalcitol, maxacalcitol, calcitriol, alfacalcidol, ercalcitriol",1.03198428600636,0.289036881004724,FALSE
+"H1648","Pearson.est","EGFR inhibitor",-0.89195,-2.17,0,1379,0.0176,"brigatinib, WZ.4002, CUDC.101, rociletinib, icotinib, TAK.285, CP.724714, BIBU.1361, WZ8040, PD.153035, AEE788, AST.1306, GW.583340, vandetanib, BIBX.1382, BMS.599626, ARRY.334543, PD.168393, pelitinib, erlotinib, gefitinib, BMS.690514, osimertinib, lapatinib, tucatinib, afatinib, dacomitinib, canertinib, neratinib, XL.647, AZD8931, poziotinib",Inf,1.75448733218585,TRUE
+"H1648","Pearson.est","Abl kinase inhibitor",-0.39874,-0.94,0.518,1393,0.801,"dasatinib, bosutinib, ZM.306416",0.285670240254767,0.0963674839157623,FALSE
+"H1648","Pearson.est","acetylcholine receptor agonist",0.46642,1.12,0.326,58,0.623,"oxiracetam",0.486782399932061,0.20551195334083,FALSE
+"H1648","Pearson.est","acetylcholine receptor antagonist",0.59632,1.46,0.0741,193,0.639,"iododexetimide, diphemanil",1.13018179202067,0.1944991418416,FALSE
+"H1648","Pearson.est","adenosine receptor antagonist",-0.46448,-1.14,0.299,1167,0.742,"PSB.1115, theophylline, MRS.1220, CGS.15943",0.52432881167557,0.129596094720973,FALSE
+"H1648","Pearson.est","adrenergic receptor agonist",-0.20377,-0.497,0.978,292,0.98,"buphenine, metaraminol, norepinephrine, isoetharine, clenbuterol, xylazine, epinephrine, lidamidine, oxymetazoline, midodrine, isoxsuprine, ritodrine, methyldopa, terbutaline, A61603",0.00966114521239857,0.00877392430750515,FALSE
+"H1648","Pearson.est","adrenergic receptor antagonist",0.17302,0.414,0.997,608,0.996,"metoprolol, oxprenolol, carvedilol, levobunolol, pindolol, idazoxan, naftidrofuryl, atipamezole, practolol",0.00130484168834428,0.00174066157630127,FALSE
+"H1648","Pearson.est","AKT inhibitor",-0.66645,-1.66,0.0511,1304,0.243,"GSK2110183, CCT128930, GDC.0068, uprosertib, triciribine",1.29157909986529,0.614393726401688,FALSE
+"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.36312,-0.907,0.522,1107,0.825,"CEP.37440, AZD3463, SB.505124, AP26113, GW.788388, brigatinib",0.282329496997738,0.0835460514500749,FALSE
+"H1648","Pearson.est","androgen receptor antagonist",0.51742,1.22,0.242,282,0.531,"nilutamide, bicalutamide",0.616184634019569,0.274905478918531,FALSE
+"H1648","Pearson.est","antioxidant",0.54248,1.32,0.162,311,0.599,"trolox, benfotiamine, chlorogenic.acid",0.790484985457369,0.222573177610689,FALSE
+"H1648","Pearson.est","AP inhibitor",0.43392,1.04,0.407,521,0.638,"idronoxil, embelin, GDC.0152, birinapant, LCL.161",0.39040559077478,0.195179321278838,FALSE
+"H1648","Pearson.est","ATPase inhibitor",0.36488,0.887,0.597,606,0.756,"digoxin, blebbistatin...., digitoxin, ouabain, oligomycin.a, thonzonium, digitoxigenin, evodiamine",0.224025668870631,0.121478204498793,FALSE
+"H1648","Pearson.est","Aurora kinase inhibitor",0.35299,0.836,0.66,394,0.798,"barasertib, tozasertib, AT.9283, AMG900, SNS.314, KW.2449, PF.03814735, hesperadin",0.180456064458131,0.0979971086492706,FALSE
+"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.60627,-1.57,0.0718,1155,0.314,"josamycin, tilmicosin, tedizolid, azithromycin",1.1438755557577,0.503070351926785,FALSE
+"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.25104,0.604,0.906,397,0.998,"novobiocin, sparfloxacin, norfloxacin",0.0428718023231869,0.000869458712628891,FALSE
+"H1648","Pearson.est","BCL inhibitor",0.58942,1.43,0.109,351,0.649,"venetoclax, oridonin, TW.37, ABT.737",0.962573502059376,0.187755303199631,FALSE
+"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.44858,1.07,0.394,194,0.67,"GZD824, bafetinib, tozasertib, ponatinib, nilotinib",0.404503778174426,0.173925197299174,FALSE
+"H1648","Pearson.est","benzodiazepine receptor agonist",0.23587,0.565,0.935,255,0.985,"indiplon, temazepam",0.0291883891274822,0.00656376950238827,FALSE
+"H1648","Pearson.est","bromodomain inhibitor",-0.26344,-0.643,0.864,1062,0.966,"I.BET151, OTX015, JQ1....",0.0634862575211067,0.0150228735845067,FALSE
+"H1648","Pearson.est","calcium channel blocker",-0.32252,-0.796,0.692,1152,0.914,"efonidipine.monoethanolate, tetrandrine, fendiline, SKF.96365",0.159893905543242,0.0390538042661686,FALSE
+"H1648","Pearson.est","CC chemokine receptor antagonist",0.62746,1.52,0.0638,378,0.648,"UNBS.5162, MK.0812, SB.225002, PF.04136309, navarixin",1.19517932127884,0.188424994129407,FALSE
+"H1648","Pearson.est","CDK inhibitor",-0.39396,-1.02,0.41,1143,0.824,"TG.02, P276.00, arcyriaflavin.a, alvocidib, aminopurvalanol.a, indirubin, BMS.387032, AT.7519",0.387216143280265,0.0840727883028842,FALSE
+"H1648","Pearson.est","CHK inhibitor",-0.31962,-0.764,0.723,1341,0.896,"LY2603618",0.140861702705469,0.0476919903378748,FALSE
+"H1648","Pearson.est","cyclooxygenase inhibitor",-0.28072,-0.711,0.802,1295,0.91,"aspirin, FK.3311, ramifenazone, amfenac, tryptanthrin",0.0958256317158365,0.0409586076789064,FALSE
+"H1648","Pearson.est","cytochrome P450 inhibitor",0.51581,1.22,0.237,400,0.531,"metyrapone, morin, cobicistat",0.625251653989896,0.274905478918531,FALSE
+"H1648","Pearson.est","DNA alkylating agent",0.38057,0.909,0.557,291,0.757,"melphalan, carboplatin, carmustine, dianhydrogalactitol, TH.302",0.254144804826271,0.120904120499927,FALSE
+"H1648","Pearson.est","DNA inhibitor",0.46745,1.13,0.315,368,0.628,"melphalan, carboplatin, chlorambucil, pibenzimol, bendamustine, carmustine, mechlorethamine, valrubicin",0.501689446210399,0.202040356262804,FALSE
+"H1648","Pearson.est","DNA methyltransferase inhibitor",-0.53335,-1.33,0.147,1337,0.608,"SGI.1027, decitabine, azacitidine",0.832682665251824,0.216096420727265,FALSE
+"H1648","Pearson.est","DNA polymerase inhibitor",-0.21458,-0.536,0.958,309,0.993,"foscarnet, famciclovir, menadione, idoxuridine, trifluridine, adefovir.dipivoxil, cidofovir, cephalomannine",0.0186344909214556,0.00305075150461883,FALSE
+"H1648","Pearson.est","DNA synthesis inhibitor",0.42421,1.02,0.453,655,0.632,"azodicarbonamide, nelarabine, artemisinin, floxuridine, artesunate, estramustine.phosphate, mitomycin.c, CB.10.277, cisplatin, anisomycin, enocitabine",0.343901797987168,0.199282921717615,FALSE
+"H1648","Pearson.est","dopamine receptor antagonist",0.24329,0.583,0.926,214,0.993,"raclopride, amisulpride, paliperidone",0.0333890133180656,0.00305075150461883,FALSE
+"H1648","Pearson.est","estrogen receptor agonist",-0.44743,-1.13,0.32,1350,0.708,"erteberel, levonorgestrel",0.494850021680094,0.149966742310231,FALSE
+"H1648","Pearson.est","estrogen receptor antagonist",0.50921,1.24,0.23,168,0.633,"toremifene, danazol, fulvestrant",0.638272163982407,0.198596289982645,FALSE
+"H1648","Pearson.est","FGFR inhibitor",0.6934,1.6,0.0202,295,0.661,"erdafitinib, dovitinib, regorafenib, nintedanib, orantinib, MK.2461, lenvatinib",1.69464863055338,0.17979854051436,FALSE
+"H1648","Pearson.est","FLT3 inhibitor",0.59841,1.42,0.1,387,0.545,"dovitinib, TG.101348, midostaurin, tozasertib, ponatinib, quizartinib, sunitinib, lestaurtinib, KW.2449, tyrphostin.AG.1296, sorafenib",1,0.263603497723358,FALSE
+"H1648","Pearson.est","glucocorticoid receptor agonist",-0.72553,-1.86,0.00948,1183,0.14,"beclomethasone.dipropionate, difluprednate, dexamethasone.acetate, fluocinolone.acetonide, methylprednisolone, fluorometholone, flumethasone.pivalate, fludroxycortide, betamethasone, halcinonide, desonide, halobetasol.propionate, clobetasol.propionate, ciclesonide, flumethasone, triamcinolone.acetonide",2.02319166266193,0.853871964321762,TRUE
+"H1648","Pearson.est","glutamate receptor antagonist",0.27994,0.677,0.869,348,0.964,"MTPG, ACDPP, felbamate",0.0609802235513335,0.0159229660971692,FALSE
+"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.45216,1.06,0.388,324,0.645,"tideglusib, CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.411168274405793,0.190440285364732,FALSE
+"H1648","Pearson.est","growth factor receptor inhibitor",-0.31056,-0.761,0.735,1348,0.868,"GSK1904529A",0.133712660915805,0.0614802748235081,FALSE
+"H1648","Pearson.est","HCV inhibitor",0.35215,0.841,0.656,412,0.809,"narlaprevir, mericitabine, embelin",0.18309616062434,0.0920514783877277,FALSE
+"H1648","Pearson.est","HDAC inhibitor",0.40851,0.995,0.446,568,0.652,"entinostat, resminostat, R306465, nexturastat.a, RG2833, trichostatin.a, M.344, dacinostat, chidamide, ACY.1215, scriptaid, vorinostat, belinostat, NSC.3852",0.350665141287858,0.18575240426808,FALSE
+"H1648","Pearson.est","histamine receptor antagonist",0.22304,0.531,0.959,407,0.985,"lafutidine, famotidine, epinastine, pheniramine, ICI.162846, tiotidine, cimetidine",0.0181813928293364,0.00656376950238827,FALSE
+"H1648","Pearson.est","HMGCR inhibitor",0.91748,2.21,0,7,0,"mevastatin, pitavastatin, atorvastatin, fluvastatin",Inf,Inf,TRUE
+"H1648","Pearson.est","HSP inhibitor",-0.29883,-0.765,0.761,1261,0.931,"VER.49009, alvespimycin, tanespimycin, KW.2478",0.118615343229427,0.0310503190186574,FALSE
+"H1648","Pearson.est","JAK inhibitor",0.36811,0.896,0.574,347,0.76,"TG.101348, tozasertib, AT.9283, TG.101209, lestaurtinib, PRT062070, AZ960",0.241088107602027,0.119186407719209,FALSE
+"H1648","Pearson.est","KIT inhibitor",0.51462,1.22,0.235,424,0.531,"pazopanib, midostaurin, regorafenib, KI.8751, masitinib, sunitinib, lenvatinib, sorafenib, telatinib, motesanib",0.628932137728264,0.274905478918531,FALSE
+"H1648","Pearson.est","MDM inhibitor",0.83688,1.96,0.00162,120,0.0379,"idasanutlin, AMG.232, nutlin.3, CGM097, serdemetan",2.79048498545737,1.42136079003193,TRUE
+"H1648","Pearson.est","MEK inhibitor",-0.57024,-1.4,0.128,1189,0.536,"cobimetinib, PD.198306, MEK162, PD.184352, PD.318088, TAK.733, PD.0325901, selumetinib, AZD8330, Ro.4987655, AS.703026, trametinib",0.892790030352132,0.27083521030723,FALSE
+"H1648","Pearson.est","MET inhibitor",-0.39786,-0.979,0.46,1408,0.81,"INC.280",0.337242168318426,0.0915149811213502,FALSE
+"H1648","Pearson.est","microtubule inhibitor",0.53761,1.28,0.184,169,0.655,"vinblastine, secnidazole, vinflunine",0.735182176990464,0.183758700008217,FALSE
+"H1648","Pearson.est","mTOR inhibitor",-0.23566,-0.581,0.935,1217,0.994,"WYE.354, PP242, PF.05212384, GDC.0980, GSK2126458",0.0291883891274822,0.00261361560268669,FALSE
+"H1648","Pearson.est","NFkB pathway inhibitor",-0.34086,-0.846,0.629,1098,0.899,"Ro.106.9920, tyloxapol, EVP4593, IKK.2.inhibitor.V",0.201349354554731,0.0462403082667712,FALSE
+"H1648","Pearson.est","opioid receptor agonist",0.50229,1.21,0.249,527,0.528,"BW.180C, cebranopadol, spiradoline, salvinorin.a",0.603800652904264,0.277366077466188,FALSE
+"H1648","Pearson.est","p38 MAPK inhibitor",-0.52411,-1.3,0.179,1087,0.599,"VX.702, CMPD.1, talmapimod, SB.239063",0.747146969020107,0.222573177610689,FALSE
+"H1648","Pearson.est","PARP inhibitor",0.54602,1.27,0.206,421,0.637,"talazoparib, AG.14361, PJ.34, olaparib, niraparib",0.686132779630847,0.19586056766465,FALSE
+"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.57471,1.39,0.146,455,0.523,"dovitinib, axitinib, pazopanib, regorafenib, KI.8751, ponatinib, nintedanib, orantinib, masitinib, sunitinib, lenvatinib, linifanib, trapidil, sorafenib, telatinib, motesanib, CP.673451, SU014813",0.835647144215563,0.281498311132726,FALSE
+"H1648","Pearson.est","phosphatase inhibitor",0.60583,1.46,0.0836,210,0.639,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, sodium.stibogluconate, CID.5458317",1.07779372256098,0.1944991418416,FALSE
+"H1648","Pearson.est","phosphodiesterase inhibitor",0.50895,1.23,0.232,31,0.59,"anagrelide, GSK256066",0.6345120151091,0.229147988357856,FALSE
+"H1648","Pearson.est","PI3K inhibitor",-0.44701,-1.12,0.317,1262,0.68,"PF.05212384, TG.100713, GDC.0980, CH5132799, GSK2126458, alpelisib, taselisib",0.498940737782249,0.167491087293764,FALSE
+"H1648","Pearson.est","PLK inhibitor",0.45519,1.08,0.365,404,0.675,"rigosertib, volasertib, GSK461364",0.437707135543525,0.170696227168975,FALSE
+"H1648","Pearson.est","potassium channel blocker",0.55655,1.33,0.159,523,0.621,"dofetilide, meglitinide, mepivacaine",0.798602875679548,0.20690839982342,FALSE
+"H1648","Pearson.est","PPAR receptor agonist",0.49215,1.17,0.274,632,0.578,"GW.501516, clofibrate, fenofibrate, ciprofibrate, pterostilbene",0.562249437179612,0.238072161579471,FALSE
+"H1648","Pearson.est","progesterone receptor agonist",0.4263,1.02,0.448,192,0.632,"norethindrone, danazol, tanaproget",0.348721986001856,0.199282921717615,FALSE
+"H1648","Pearson.est","proteasome inhibitor",0.53722,1.26,0.197,367,0.623,"ixazomib, delanzomib, MG.132, ONX.0914, oprozomib",0.705533773838407,0.20551195334083,FALSE
+"H1648","Pearson.est","protein synthesis inhibitor",0.33743,0.805,0.716,582,0.827,"brefeldin.a, mercaptopurine, anguidine, harringtonine, homoharringtonine, methacycline, clofoctol, clindamycin.phosphate, cycloheximide, azomycin..2.nitroimidazole.",0.145086977692144,0.0824944904474534,FALSE
+"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.72814,-1.82,0.0172,1232,0.143,"tyrphostin.A9, NVP.TAE226, CP.724714, AV.412, BMS.599626",1.76447155309245,0.844663962534938,TRUE
+"H1648","Pearson.est","RAF inhibitor",0.58757,1.42,0.106,147,0.545,"dabrafenib, vemurafenib, regorafenib, TAK.632",0.97469413473523,0.263603497723358,FALSE
+"H1648","Pearson.est","RET tyrosine kinase inhibitor",-0.39978,-0.994,0.449,1422,0.826,"vandetanib",0.347753658996677,0.0830199526796178,FALSE
+"H1648","Pearson.est","retinoid receptor agonist",0.29503,0.715,0.827,44,0.937,"fenretinide",0.0824944904474534,0.0282604091122217,FALSE
+"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.65129,1.56,0.0513,299,0.642,"pentostatin, cladribine, clofarabine, triapine, fludarabine, hydroxyurea",1.28988263488818,0.192464971931147,FALSE
+"H1648","Pearson.est","serotonin receptor agonist",0.58453,1.4,0.115,399,0.546,"NAN.190, aripiprazole, SR.57227A",0.939302159646388,0.262807357295263,FALSE
+"H1648","Pearson.est","serotonin receptor antagonist",0.40648,0.992,0.463,382,0.64,"lerisetron, SB.200646, paliperidone, aripiprazole, pirenperone",0.334419008982047,0.193820026016113,FALSE
+"H1648","Pearson.est","sodium channel blocker",0.26406,0.629,0.901,313,0.995,"oxcarbazepine, quinidine, cibenzoline, triamterene",0.045275209020937,0.00217691925427455,FALSE
+"H1648","Pearson.est","src inhibitor",-0.73062,-1.79,0.0188,1393,0.142,"dasatinib, bosutinib, ZM.306416, saracatinib",1.72584215073632,0.847711655616944,TRUE
+"H1648","Pearson.est","sterol demethylase inhibitor",0.43852,1.06,0.379,441,0.645,"chlormidazole, ketoconazole, posaconazole, lanoconazole",0.421360790031928,0.190440285364732,FALSE
+"H1648","Pearson.est","TGF beta receptor inhibitor",-0.49566,-1.26,0.236,1402,0.615,"repsox",0.627087997029893,0.211124884224583,FALSE
+"H1648","Pearson.est","thymidylate synthase inhibitor",-0.3288,-0.814,0.68,1231,0.921,"carmofur, capecitabine",0.167491087293764,0.0357403698031511,FALSE
+"H1648","Pearson.est","topoisomerase inhibitor",0.50685,1.23,0.218,457,0.59,"nemorubicin, etoposide.phosphate, topotecan, epirubicin, doxorubicin, teniposide, daunorubicin, voreloxin, etoposide, amonafide, amsacrine, valrubicin, rubitecan, TAS.103, idarubicin, mitoxantrone",0.661543506395395,0.229147988357856,FALSE
+"H1648","Pearson.est","tubulin polymerization inhibitor",0.4393,1.05,0.411,343,0.642,"vinblastine, verubulin, BNC105, taltobulin, combretastatin.A.4, vindesine, CYT.997, KX2.391, vincristine",0.386158178123931,0.192464971931147,FALSE
+"H1648","Pearson.est","tyrosine kinase inhibitor",-0.47166,-1.16,0.273,1283,0.76,"aminopurvalanol.a, NVP.TAE226, tivantinib, dasatinib, CP.724714, vandetanib, AV.412, BMS.599626",0.563837352959244,0.119186407719209,FALSE
+"H1648","Pearson.est","VEGFR inhibitor",-0.36842,-0.964,0.468,1416,0.796,"AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.329754146925876,0.0990869322623309,FALSE
+"H1648","Pearson.est","vitamin D receptor agonist",-0.80381,-1.99,0.0092,1296,0.0677,"paricalcitol, calcitriol, ercalcitriol, tacalcitol, maxacalcitol",2.03621217265444,1.16941133131486,TRUE
+"H2126","Pearson.est","EGFR inhibitor",-0.86724,-2.17,0.00216,1354,0.00217,"icotinib, rociletinib, WZ.4002, pelitinib, WZ8040, TAK.285, BIBU.1361, AST.1306, AEE788, vandetanib, ARRY.334543, PD.153035, BIBX.1382, erlotinib, CP.724714, BMS.599626, GW.583340, CUDC.101, afatinib, dacomitinib, PD.168393, gefitinib, canertinib, osimertinib, BMS.690514, lapatinib, XL.647, neratinib, poziotinib, AZD8931, tucatinib",2.66554624884907,2.66354026615147,TRUE
+"H2126","Pearson.est","Abl kinase inhibitor",0.45125,1.11,0.324,246,0.633,"ponatinib, GZD824, tozasertib, KW.2449, bafetinib, nilotinib",0.489454989793388,0.198596289982645,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",-0.26374,-0.666,0.871,1099,0.965,"pilocarpine, nefiracetam, nicotine",0.0599818449923368,0.0154726866562074,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",0.32382,0.789,0.69,152,0.807,"iododexetimide",0.161150909262745,0.0931264652779296,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.7266,-1.76,0.0281,1366,0.145,"SCH.58261, MRS.1220, CGS.15943",1.55129368009492,0.838631997765025,TRUE
+"H2126","Pearson.est","adrenergic receptor agonist",-0.26169,-0.641,0.877,375,0.963,"midodrine, buphenine, clenbuterol, lidamidine, terbutaline, norepinephrine, methyldopa, isoetharine, oxymetazoline, xylazine, epinephrine, ritodrine, metaraminol, A61603, isoxsuprine",0.0570004066339595,0.0163737128754655,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",0.21324,0.528,0.979,229,1,"metoprolol, idazoxan, oxprenolol, carvedilol",0.00921730819686218,0,FALSE
+"H2126","Pearson.est","AKT inhibitor",-0.70537,-1.71,0.0375,1209,0.167,"palomid.529, A.674563, CCT128930, triciribine, GSK2110183, uprosertib, GDC.0068",1.42596873227228,0.777283528852417,TRUE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.2547,-0.622,0.884,1087,0.953,"SB.505124, AP26113, GW.788388, CEP.37440, brigatinib",0.0535477349869269,0.0209070993616736,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",0.43757,1.04,0.413,406,0.661,"nilutamide, bicalutamide, cyproterone.acetate",0.384049948343599,0.17979854051436,FALSE
+"H2126","Pearson.est","antioxidant",0.50052,1.25,0.203,707,0.512,"benfotiamine, trolox, chlorogenic.acid, taurine, rutin",0.692503962086787,0.290730039024169,FALSE
+"H2126","Pearson.est","AP inhibitor",0.3872,0.941,0.524,511,0.745,"idronoxil, GDC.0152, LCL.161, embelin, birinapant",0.280668713016273,0.127843727251707,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.52196,1.27,0.211,281,0.527,"ouabain, digitoxin, thonzonium, digoxin, digitoxigenin, blebbistatin....",0.675717544702307,0.278189384787453,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.41638,1.02,0.414,275,0.674,"barasertib, tozasertib, AMG900, AT.9283, KW.2449, SNS.314, barasertib.HQPA, PF.03814735, hesperadin",0.382999658879101,0.17134010346468,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45003,-1.09,0.338,1045,0.742,"azalomycin.b, tilmicosin, tedizolid, azithromycin",0.471083299722345,0.129596094720973,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.47933,1.15,0.307,141,0.612,"sparfloxacin, novobiocin",0.512861624522813,0.213248577854439,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.28421,0.681,0.839,644,0.913,"ABT.737, venetoclax, TW.37, obatoclax, navitoclax",0.0762380391712997,0.039529222465701,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.5544,1.37,0.15,246,0.488,"ponatinib, GZD824, tozasertib, bafetinib, nilotinib",0.823908740944319,0.311580177997289,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",-0.16585,-0.407,0.998,238,0.998,"indiplon, temazepam, piperazine, gamma.aminobutyric.acid, CL.218872, zaleplon, bentazepam, eprinomectin, ZK.93423, CGS.20625, ivermectin, nefiracetam, lorazepam",0.000869458712628891,0.000869458712628891,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",-0.72706,-1.77,0.0169,1257,0.17,"I.BET151, OTX015, JQ1....",1.77211329538633,0.769551078621726,TRUE
+"H2126","Pearson.est","calcium channel blocker",-0.38939,-0.934,0.521,1037,0.839,"SR.33805, mibefradil, tetrandrine, SKF.96365, fendiline",0.283162276700476,0.0762380391712997,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.5135,1.27,0.22,330,0.527,"UNBS.5162, SB.225002, MK.0812",0.657577319177794,0.278189384787453,FALSE
+"H2126","Pearson.est","CDK inhibitor",-0.40547,-0.99,0.449,1278,0.814,"TG.02, aminopurvalanol.a, AT.7519, BMS.387032, arcyriaflavin.a, indirubin",0.347753658996677,0.0893755951107988,FALSE
+"H2126","Pearson.est","CHK inhibitor",0.54258,1.32,0.183,185,0.521,"SCH.900776, PF.477736, LY2606368",0.737548910269571,0.283162276700476,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.27752,-0.69,0.825,1107,0.965,"meloxicam, FR.122047, ramifenazone, FK.3311, aspirin, amfenac, tryptanthrin",0.0835460514500749,0.0154726866562074,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",0.56422,1.35,0.151,523,0.496,"metyrapone, morin, itraconazole, clotrimazole, cobicistat",0.821023052706831,0.304518323509803,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.35312,0.843,0.61,404,0.763,"melphalan, carboplatin, carmustine, estramustine, temozolomide, streptozotocin",0.214670164989233,0.11747546204512,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.37844,0.922,0.548,125,0.757,"melphalan, chlorambucil, carboplatin",0.261219441515631,0.120904120499927,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",-0.45724,-1.12,0.31,1170,0.729,"fdcyd, decitabine, SGI.1027, azacitidine",0.508638306165727,0.137272471682025,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",-0.19931,-0.49,0.983,287,1,"trifluridine, foscarnet, adefovir.dipivoxil, famciclovir, idoxuridine, menadione, cephalomannine, cidofovir",0.00744648216786438,0,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",0.45866,1.11,0.333,636,0.633,"nelarabine, floxuridine, artemisinin, azodicarbonamide, cisplatin, anisomycin, altretamine, artesunate, cyclocytidine, capecitabine",0.47755576649368,0.198596289982645,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.29074,-0.715,0.768,1053,0.998,"piperacetazine, mesoridazine, acetophenazine, oxiperomide, ziprasidone, lurasidone, nemonapride, clebopride, remoxipride",0.114638779968488,0.000869458712628891,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",-0.29167,-0.692,0.815,420,0.997,"estrone, estradiol, PPT, estradiol.cypionate, equol, ethinyl.estradiol, levonorgestrel, erteberel",0.0888423912600234,0.00130484168834428,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",0.33035,0.809,0.669,357,0.797,"toremifene, danazol, fulvestrant",0.174573882232177,0.0985416786038876,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.7074,1.74,0.0197,215,0.443,"erdafitinib, dovitinib, regorafenib, lenvatinib, MK.2461",1.70553377383841,0.35359627377693,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.5369,1.3,0.19,198,0.529,"ponatinib, dovitinib, tozasertib, lestaurtinib, midostaurin, tyrphostin.AG.1296, KW.2449, gilteritinib, sunitinib",0.721246399047171,0.276544327964814,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",-0.56321,-1.4,0.118,1068,0.489,"betamethasone, fluocinolone.acetonide, beclomethasone.dipropionate, flumethasone.pivalate, desonide, difluprednate, rimexolone, fludroxycortide, ciclesonide, halobetasol.propionate, halcinonide, methylprednisolone, flumethasone, clobetasol.propionate, triamcinolone.acetonide",0.928117992693875,0.31069114087638,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.40577,-0.994,0.457,1125,0.851,"LY456236, CPP, latrepirdine, tiletamine, CGP.37849",0.34008379993015,0.0700704399154121,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.31878,-0.783,0.718,1417,1,"indirubin",0.1438755557577,0,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.39608,0.971,0.462,236,0.738,"lestaurtinib, PHA.848125, GSK1838705A",0.335358024443874,0.131943638176958,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.3922,0.961,0.479,532,0.732,"narlaprevir, mericitabine, embelin, Ro.9187",0.319664486585437,0.135488918941608,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.60432,-1.5,0.0887,1214,0.359,"M.344, AR.42, tacedinaline, mocetinostat, pyroxamide, PCI.24781, givinostat, romidepsin, JNJ.26481585, SB.939",1.05207638016827,0.444905551421681,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",0.20735,0.505,0.969,378,0.997,"cimetidine, pheniramine, tiotidine, famotidine, lafutidine, astemizole",0.0136762229492347,0.00130484168834428,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",0.9542,2.32,0,6,0,"atorvastatin, mevastatin, fluvastatin, pitavastatin",Inf,Inf,TRUE
+"H2126","Pearson.est","HSP inhibitor",0.34524,0.848,0.636,165,0.776,"NMS.E973, SNX.2112, NVP.AUY922, ganetespib",0.196542884351586,0.110138278741812,FALSE
+"H2126","Pearson.est","JAK inhibitor",0.30446,0.731,0.787,228,0.868,"tozasertib, lestaurtinib, AT.9283, PRT062070",0.104025267640935,0.0614802748235081,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.58701,1.44,0.0951,396,0.422,"KI.8751, midostaurin, pazopanib, regorafenib, lenvatinib, motesanib, sunitinib, telatinib, cediranib, sorafenib",1.02181948306259,0.374687549038326,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.37397,-0.904,0.541,1410,0.858,"RITA",0.266802734893431,0.0665127121512946,FALSE
+"H2126","Pearson.est","MEK inhibitor",-0.46812,-1.15,0.3,1060,0.716,"AZD8330, PD.0325901, TAK.733, MEK162, PD.184352, Ro.4987655, AS.703026, selumetinib, PD.198306, trametinib",0.522878745280338,0.145086977692144,FALSE
+"H2126","Pearson.est","MET inhibitor",0.35939,0.873,0.581,292,0.796,"LY2801653, AMG458, PHA.665752",0.235823867609669,0.0990869322623309,FALSE
+"H2126","Pearson.est","microtubule inhibitor",0.67072,1.66,0.0394,223,0.53,"vinblastine, vinflunine, podophyllotoxin, cabazitaxel, secnidazole",1.40450377817443,0.275724130399211,FALSE
+"H2126","Pearson.est","mTOR inhibitor",-0.50166,-1.22,0.253,1077,0.631,"LY303511, AZD8055, torin.2, voxtalisib, WYE.354, XL388, palomid.529, PF.05212384, WYE.125132, PP242, PI.103, GDC.0980, GSK2126458",0.596879478824182,0.199970640755866,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.31237,-0.762,0.742,1142,0.96,"IKK.2.inhibitor.V, Ro.106.9920, EVP4593, tyloxapol",0.129596094720973,0.0177287669604316,FALSE
+"H2126","Pearson.est","opioid receptor agonist",0.44966,1.09,0.36,461,0.643,"spiradoline, BW.180C, cebranopadol",0.443697499232713,0.191789027075778,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",-0.51297,-1.27,0.189,884,0.581,"TAK.715, talmapimod, CMPD.1, VX.702, SB.239063",0.723538195826756,0.235823867609669,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.6418,1.56,0.0664,341,0.472,"talazoparib, olaparib, niraparib, AZD2461",1.17783192063198,0.326058001365912,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.61003,1.52,0.0811,198,0.35,"ponatinib, dovitinib, axitinib, SU014813, KI.8751, pazopanib, CP.673451, regorafenib, lenvatinib, motesanib, sunitinib",1.09097914578884,0.455931955649724,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.50164,1.22,0.25,139,0.515,"bis.maltolato.oxovanadium.IV., BVT.948, GSK2830371, sodium.stibogluconate",0.602059991327962,0.288192770958809,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",0.35648,0.861,0.593,78,0.774,"anagrelide, GSK256066",0.226945306635737,0.111259039317107,FALSE
+"H2126","Pearson.est","PI3K inhibitor",-0.53664,-1.37,0.155,1176,0.493,"voxtalisib, PI3K.IN.2, CUDC.907, PI.828, TG.100713, PF.05212384, PI.103, GDC.0980, CH5132799, GSK2126458, alpelisib, taselisib",0.809668301829709,0.30715308072277,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.66608,1.65,0.0264,137,0.424,"rigosertib, volasertib, GSK461364",1.57839607313017,0.372634143407267,FALSE
+"H2126","Pearson.est","potassium channel blocker",0.26828,0.657,0.861,148,0.922,"dofetilide",0.0649968485463452,0.0352690789463706,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",0.51265,1.23,0.229,362,0.521,"fenofibrate, clofibrate",0.640164517660112,0.283162276700476,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",0.42929,1.06,0.362,389,0.672,"norethindrone, danazol, tanaproget, norgestrel",0.441291429466834,0.172630726946175,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.6389,1.55,0.081,508,0.428,"ixazomib, delanzomib, bortezomib, MG.132, ONX.0914, carfilzomib, oprozomib",1.09151498112135,0.368556230986828,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.35243,0.866,0.607,464,0.786,"mercaptopurine, brefeldin.a, methacycline, homoharringtonine, anguidine, harringtonine, clofoctol, cycloheximide",0.216811308924742,0.104577453960592,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.77092,-1.94,0.00858,1243,0.0561,"NVP.TAE226, mubritinib, tyrphostin.A9, AV.412, CP.724714, BMS.599626",2.06651271215129,1.25103713874384,TRUE
+"H2126","Pearson.est","RAF inhibitor",0.61355,1.51,0.069,423,0.335,"dabrafenib, vemurafenib, RAF265, regorafenib, GDC.0879, LGX818, sorafenib, AZ.628",1.16115090926274,0.474955192963155,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",-0.38902,-0.958,0.501,1415,0.832,"vandetanib",0.300162274132754,0.0798766737092761,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",-0.31062,-0.768,0.731,1306,0.988,"CD.437, AM.580",0.13608262304214,0.00524305541237188,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.6275,1.53,0.0739,400,0.417,"cladribine, clofarabine, triapine, pentostatin, fludarabine.phosphate, gemcitabine, fludarabine, hydroxyurea",1.13135556160517,0.379863945026242,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",0.57007,1.39,0.141,203,0.485,"aripiprazole, NAN.190, SR.57227A",0.85078088734462,0.314258261397736,FALSE
+"H2126","Pearson.est","serotonin receptor antagonist",0.36068,0.884,0.618,104,0.799,"lerisetron, aripiprazole, paliperidone",0.209011524911184,0.0974532206860086,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.16836,0.412,0.998,556,0.997,"quinidine, cibenzoline, oxcarbazepine, mexiletine, mepivacaine, benzocaine",0.000869458712628891,0.00130484168834428,FALSE
+"H2126","Pearson.est","src inhibitor",-0.64915,-1.58,0.058,1379,0.286,"bosutinib, saracatinib, ZM.306416",1.23657200643706,0.543633966870957,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.42516,1.04,0.397,347,0.661,"chlormidazole, ketoconazole, posaconazole",0.401209493236885,0.17979854051436,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",-0.41244,-1.01,0.404,1300,0.866,"repsox",0.393618634889395,0.0624821079826534,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.5018,1.26,0.203,636,0.521,"trifluridine, raltitrexed, ftorafur, capecitabine",0.692503962086787,0.283162276700476,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.6422,1.6,0.0594,373,0.455,"topotecan, etoposide.phosphate, nemorubicin, teniposide, irinotecan, daunorubicin, rubitecan, doxorubicin, etoposide, voreloxin, dexrazoxane, mitoxantrone, TAS.103, amonafide, SN.38, idarubicin, amsacrine",1.22621355501881,0.341988603342888,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.63468,1.52,0.0797,356,0.35,"verubulin, BNC105, vinblastine, taltobulin, vindesine, CYT.997, podophyllotoxin, vincristine, combretastatin.A.4, dolastatin.10, KX2.391, docetaxel, plinabulin, paclitaxel, ABT.751, fosbretabulin",1.09854167860389,0.455931955649724,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",-0.52153,-1.27,0.191,1243,0.581,"NVP.TAE226, aminopurvalanol.a, GTP.14564, mubritinib, tyrphostin.A9, AV.412, vandetanib, CP.724714, BMS.599626",0.718966632752272,0.235823867609669,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",-0.37074,-0.902,0.563,1393,0.824,"semaxanib, AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.249491605148654,0.0840727883028842,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.88006,-2.19,0,1320,0.00434,"alfacalcidol, ercalcitriol, paricalcitol, calcitriol, maxacalcitol, tacalcitol",Inf,2.36251027048749,TRUE
+"H520","Pearson.est","EGFR inhibitor",0.49961,1.35,0.162,216,0.479,"PD.153035, icotinib, vandetanib, poziotinib, erlotinib, osimertinib, pelitinib, canertinib, XL.647, gefitinib, tyrphostin.AG.494, BIBU.1361, PD.168393, dacomitinib, AZD8931, lapatinib, afatinib",0.790484985457369,0.319664486585437,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",0.64733,1.71,0.0522,368,0.246,"dasatinib, ponatinib, GZD824, ZM.306416, bosutinib, metatinib, nilotinib, bafetinib",1.28232949699774,0.609064892896621,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",-0.33752,-0.83,0.677,1360,0.944,"xanomeline",0.169411331314856,0.025028005701931,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",-0.34912,-0.843,0.626,1302,1,"diphemanil",0.20342566678957,0,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",-0.2738,-0.668,0.869,1152,0.933,"sulmazole",0.0609802235513335,0.0301183562535,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.5232,1.42,0.133,91,0.424,"isoxsuprine, ritodrine, oxymetazoline, epinephrine",0.876148359032914,0.372634143407267,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",-0.35943,-0.897,0.589,939,0.922,"RS.17053, atipamezole, practolol, carvedilol, propranolol, metoprolol, pindolol, dihydroergocristine",0.229884705212898,0.0352690789463706,FALSE
+"H520","Pearson.est","AKT inhibitor",-0.46606,-1.14,0.276,1146,0.782,"ONC201, GSK2110183, uprosertib, A.674563, GDC.0068",0.559090917934782,0.106793246940152,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.27771,0.726,0.765,62,1,"GW.788388, lorlatinib",0.116338564846382,0,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.24341,0.65,0.893,1097,1,"bicalutamide, RU.58841, nilutamide, cyproterone.acetate, enzalutamide, flutamide",0.0491485411114536,0,FALSE
+"H520","Pearson.est","antioxidant",0.60798,1.63,0.0354,290,0.215,"mesna, chlorogenic.acid, rutin",1.45099673797421,0.667561540084395,TRUE
+"H520","Pearson.est","AP inhibitor",0.76211,2,0.00556,96,0.114,"GDC.0152, birinapant, LCL.161",2.25492520841794,0.943095148663527,TRUE
+"H520","Pearson.est","ATPase inhibitor",-0.4592,-1.11,0.369,1148,0.814,"NMS.873, rabeprazole, digoxin, evodiamine, oligomycin.a",0.43297363384094,0.0893755951107988,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.75696,-1.86,0.00312,1252,0.13,"ENMD.2076, alisertib, AMG900, PF.03814735, MK.8745, SNS.314, TAK.901, AT.9283, danusertib, ZM.447439, barasertib, CCT137690, barasertib.HQPA, PHA.680632",2.50584540598156,0.886056647693163,TRUE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.22639,0.595,0.955,1122,0.991,"tedizolid, dirithromycin, tilmicosin, azithromycin, azalomycin.b, valnemulin, radezolid, josamycin",0.0199966284162537,0.00392634551472468,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.30754,0.837,0.638,385,1,"finafloxacin, sparfloxacin, novobiocin, sarafloxacin, trovafloxacin",0.195179321278838,0,FALSE
+"H520","Pearson.est","BCL inhibitor",-0.2786,-0.685,0.834,915,0.954,"ABT.737, oridonin, navitoclax, TW.37",0.0788339493622613,0.0204516252959049,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.65125,1.71,0.0395,368,0.246,"dasatinib, ponatinib, GZD824, bosutinib, metatinib, nilotinib, bafetinib",1.40340290437354,0.609064892896621,TRUE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.20279,0.539,0.961,1157,0.997,"piperazine, lorazepam, eprinomectin, CGS.20625, gamma.aminobutyric.acid, CL.218872, temazepam, indiplon, nefiracetam, ivermectin, ZK.93423, zaleplon, bentazepam",0.0172766123314547,0.00130484168834428,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.85229,-2.09,0,1229,0.0145,"JQ1...., PFI.1, I.BET.762, bromosporine, I.BET151, OTX015",Inf,1.83863199776503,TRUE
+"H520","Pearson.est","calcium channel blocker",0.24339,0.639,0.877,1098,1,"SKF.96365, efonidipine.monoethanolate, cinnarazine, fendiline, SR.33805, pranidipine, mibefradil, carboxyamidotriazole, tetrandrine, penfluridol",0.0570004066339595,0,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",0.30934,0.833,0.651,29,1,"navarixin",0.186419011431808,0,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.409,-0.998,0.459,1210,0.829,"PHA.793887, abemaciclib, TG.02, R547, arcyriaflavin.a, indisulam",0.338187314462739,0.0814454694497265,FALSE
+"H520","Pearson.est","CHK inhibitor",-0.59313,-1.47,0.0864,1338,0.477,"SB.218078, PF.477736",1.06348625752111,0.321481620959886,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",-0.26814,-0.655,0.866,949,0.927,"meloxicam, suxibuzone, FR.122047, pterostilbene, piroxicam, tepoxalin, AM.404, sulfasalazine, naproxen",0.0624821079826534,0.0329202658555029,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.61072,1.7,0.0452,105,0.215,"morin, metyrapone",1.34486156518862,0.667561540084395,TRUE
+"H520","Pearson.est","DNA alkylating agent",-0.43159,-1.07,0.386,1167,0.836,"dianhydrogalactitol, melphalan, TH.302, satraplatin, mitomycin.c",0.413412695328245,0.0777937225609836,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.46315,-1.14,0.3,1206,0.782,"pibenzimol, melphalan, tirapazamine, chlorambucil, primaquine, bendamustine, mechlorethamine, valrubicin",0.522878745280338,0.106793246940152,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.64775,-1.6,0.0359,1115,0.348,"disulfiram, fdcyd, SGI.1027",1.44490555142168,0.458420756053419,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",-0.27711,-0.671,0.858,1055,0.95,"cephalomannine, famciclovir, idoxuridine",0.0665127121512946,0.0222763947111523,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.29304,-0.723,0.813,1164,1,"artemisinin, enocitabine, azodicarbonamide, mitomycin.c",0.0899094544059319,0,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",0.34358,0.906,0.54,299,1,"clebopride, acetophenazine, isofloxythepin, oxiperomide, piperacetazine",0.267606240177031,0,FALSE
+"H520","Pearson.est","estrogen receptor agonist",-0.25278,-0.626,0.9,364,0.935,"PPT, estradiol, levonorgestrel, erteberel, estrone, ethinyl.estradiol, estradiol.cypionate, equol",0.0457574905606751,0.0291883891274822,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",-0.22649,-0.56,0.948,1040,0.969,"danazol, toremifene",0.0231916626619338,0.0136762229492347,FALSE
+"H520","Pearson.est","FGFR inhibitor",-0.47952,-1.17,0.262,1037,0.893,"erdafitinib, dovitinib, lenvatinib, regorafenib, nintedanib",0.581698708680255,0.0491485411114536,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.44257,-1.08,0.393,1129,0.85,"quizartinib, sorafenib, dovitinib, pacritinib, TG.02, ENMD.2076, TG.101348",0.405607449624573,0.0705810742857073,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",0.30408,0.782,0.681,77,1,"hydrocortisone, fluocinolone.acetonide, dexamethasone.acetate",0.166852888087215,0,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",0.29937,0.79,0.718,173,1,"SIB.1757, diazooxonorleucine, latrepirdine, MTPG",0.1438755557577,0,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.40645,1.08,0.34,183,0.785,"LY2090314, CHIR.98014, tideglusib",0.468521082957745,0.105130343254747,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.29785,-0.726,0.808,1385,1,"danusertib",0.0925886392254138,0,FALSE
+"H520","Pearson.est","HCV inhibitor",-0.41349,-1.01,0.44,1187,0.866,"mericitabine, narlaprevir",0.356547323513813,0.0624821079826534,FALSE
+"H520","Pearson.est","HDAC inhibitor",-0.56194,-1.38,0.137,1131,0.547,"NSC.3852, vorinostat, ACY.1215, trichostatin.a, R306465, resminostat, RGFP966, chidamide, dacinostat, PCI.24781, pyroxamide, SB.939, scriptaid, givinostat, M.344",0.863279432843593,0.262012673666569,FALSE
+"H520","Pearson.est","histamine receptor antagonist",0.15643,0.418,0.994,227,0.997,"astemizole, ranitidine, terfenadine",0.00261361560268669,0.00130484168834428,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.75698,1.97,0.00282,214,0.0928,"fluvastatin, lovastatin, pitavastatin, mevastatin",2.54975089168064,1.03245202378114,TRUE
+"H520","Pearson.est","HSP inhibitor",-0.40548,-1,0.479,809,0.856,"PU.H71, guanidine, SNX.2112, KW.2478, VER.49009, tanespimycin, NMS.E973",0.319664486585437,0.0675262353228468,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.46296,-1.14,0.298,1153,0.782,"pacritinib, TG.02, AZ960, LY2784544, TG.101348, AT.9283",0.525783735923745,0.106793246940152,FALSE
+"H520","Pearson.est","KIT inhibitor",-0.36927,-0.902,0.598,1132,0.942,"sorafenib, vatalanib, OSI.930, lenvatinib, masitinib, regorafenib, pazopanib",0.223298816011589,0.0259490972071227,FALSE
+"H520","Pearson.est","MDM inhibitor",0.27601,0.71,0.803,1050,1,"idasanutlin, nutlin.3, AMG.232, CGM097, RITA, serdemetan",0.095284454721319,0,FALSE
+"H520","Pearson.est","MEK inhibitor",0.79186,2.17,0,63,0.058,"TAK.733, refametinib, AZD8330, cobimetinib, trametinib, Ro.4987655, PD.0325901, AS.703026, PD.318088, selumetinib, MEK162",Inf,1.23657200643706,TRUE
+"H520","Pearson.est","MET inhibitor",-0.38068,-0.932,0.527,1046,0.941,"INC.280, NVP.BVU972, AMG458",0.278189384787453,0.0264103765727431,FALSE
+"H520","Pearson.est","microtubule inhibitor",-0.45925,-1.14,0.312,827,0.782,"secnidazole, vinblastine, estramustine.phosphate, cabazitaxel, D.64131, colchicine, vinflunine",0.505845405981557,0.106793246940152,FALSE
+"H520","Pearson.est","mTOR inhibitor",0.46906,1.24,0.231,419,0.578,"WAY.600, LY3023414, temsirolimus, torin.1, SB.2343, OSI.027, AZD2014, NVP.BEZ235, everolimus, PP242, MLN0128, XL388, LY303511, sirolimus, PF.04691502, AZD8055",0.636388020107856,0.238072161579471,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",-0.28545,-0.696,0.824,1423,0.962,"BAY.11.7082",0.0840727883028842,0.0168249279621871,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.47643,1.28,0.167,100,0.554,"ADL5859, BW.180C",0.777283528852417,0.25649023527157,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.32939,-0.815,0.669,1312,0.945,"talmapimod",0.174573882232177,0.0245681914907371,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.61147,-1.54,0.064,1208,0.37,"olaparib, AZD2461, PJ.34, niraparib, talazoparib",1.19382002601611,0.431798275933005,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37252,-0.914,0.559,1132,0.948,"sorafenib, vatalanib, dovitinib, linifanib, trapidil, crenolanib, lenvatinib, masitinib, regorafenib, pazopanib, nintedanib",0.252588192113577,0.0231916626619338,FALSE
+"H520","Pearson.est","phosphatase inhibitor",-0.28858,-0.709,0.812,1103,0.967,"AS.1949490, CID.5458317, mycophenolate.mofetil",0.0904439707588247,0.0145735259169983,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",-0.29976,-0.748,0.785,1043,1,"enoximone, avanafil, cilostamide",0.105130343254747,0,FALSE
+"H520","Pearson.est","PI3K inhibitor",-0.14543,-0.355,1,882,0.999,"PKI.179, PI.103, YM.201636, PF.05212384, idelalisib, alpelisib, PI3K.IN.2, CH5132799, CUDC.907, taselisib",0,0.000434511774017692,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.67592,-1.64,0.0368,974,0.328,"GW.843682X, rigosertib, GSK461364, HMN.214, BI.2536, NMS.1286937, volasertib",1.43415218132648,0.484126156288321,FALSE
+"H520","Pearson.est","potassium channel blocker",0.2337,0.619,0.915,1111,1,"meglitinide, mepivacaine, oleoylethanolamide, ML133, ibutilide, dofetilide",0.0385789059335517,0,FALSE
+"H520","Pearson.est","PPAR receptor agonist",-0.50435,-1.22,0.233,1358,0.81,"ciprofibrate, GW.501516",0.632644078973981,0.0915149811213502,FALSE
+"H520","Pearson.est","progesterone receptor agonist",0.28006,0.736,0.749,1045,1,"norethindrone, nomegestrol.acetate, levonorgestrel, dienogest, melengestrol.acetate, norethindrone.acetate, norgestrel, danazol, tanaproget",0.125518182300534,0,FALSE
+"H520","Pearson.est","proteasome inhibitor",-0.34265,-0.836,0.64,1022,0.959,"delanzomib, oprozomib, MG.132",0.193820026016113,0.0181813928293364,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.50392,-1.24,0.22,1310,0.811,"azomycin..2.nitroimidazole., clofoctol, harringtonine, bruceantin, homoharringtonine, anguidine",0.657577319177794,0.090979145788844,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.42566,-1.06,0.388,874,0.791,"rheochrysidin, NVP.TAE226, AV.412, tyrphostin.A9, mubritinib, CP.724714",0.411168274405793,0.101823516502323,FALSE
+"H520","Pearson.est","RAF inhibitor",0.368,0.969,0.456,203,0.986,"dabrafenib, LGX818, vemurafenib, CEP.32496, AZ.628",0.341035157335565,0.0061230850587888,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",0.364,0.962,0.476,24,0.942,"vandetanib",0.322393047279507,0.0259490972071227,FALSE
+"H520","Pearson.est","retinoid receptor agonist",-0.6489,-1.58,0.0494,1332,0.336,"bexarotene, adarotene, fenretinide",1.30627305107635,0.473660722610156,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.58793,-1.45,0.0909,859,0.472,"fludarabine, cladribine, fludarabine.phosphate, hydroxyurea, gemcitabine, LY2334737, clofarabine, cytarabine, pentostatin",1.04143611677803,0.326058001365912,FALSE
+"H520","Pearson.est","serotonin receptor agonist",-0.6719,-1.69,0.0241,1403,0.281,"zolmitriptan, aripiprazole",1.61798295742513,0.55129368009492,FALSE
+"H520","Pearson.est","serotonin receptor antagonist",-0.55509,-1.36,0.138,1306,0.552,"SB.200646, aripiprazole",0.860120913598763,0.258060922270801,FALSE
+"H520","Pearson.est","sodium channel blocker",-0.29237,-0.709,0.818,854,0.967,"butamben, cibenzoline, lappaconite, oxcarbazepine, brivaracetam, triamterene, benzethonium",0.087246696328677,0.0145735259169983,FALSE
+"H520","Pearson.est","src inhibitor",0.45039,1.22,0.22,112,0.565,"dasatinib, PP.2, saracatinib",0.657577319177794,0.247951552180562,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",-0.34192,-0.842,0.652,1192,0.974,"posaconazole, chlormidazole",0.18575240426808,0.0114410431213845,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",0.31641,0.85,0.635,246,1,"repsox, LY2109761",0.197226274708024,0,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",0.61616,1.63,0.0663,322,0.215,"capecitabine, carmofur, ftorafur",1.17848647159523,0.667561540084395,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",-0.71823,-1.75,0.00995,1215,0.232,"dexrazoxane, SN.38, genz.644282, doxorubicin, TAS.103, topotecan, teniposide, daunorubicin, nemorubicin, epirubicin, mitoxantrone, amsacrine, voreloxin, etoposide, etoposide.phosphate, valrubicin, amonafide",2.00217691925427,0.6345120151091,TRUE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.58163,-1.43,0.0929,937,0.476,"indibulin, epothilone.b, nocodazole, paclitaxel, vindesine, mebendazole, plinabulin, dolastatin.10, verubulin, parbendazole, flubendazole, CYT.997, vincristine, vinorelbine, fosbretabulin, ABT.751, fenbendazole, combretastatin.A.4, taltobulin, albendazole, KX2.391",1.03198428600636,0.322393047279507,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",0.26214,0.69,0.859,24,1,"dasatinib, vandetanib",0.0660068361687577,0,FALSE
+"H520","Pearson.est","VEGFR inhibitor",-0.28481,-0.713,0.805,1070,1,"axitinib, AEE788, sorafenib, vatalanib, dovitinib, linifanib, OSI.930, ENMD.2076, lenvatinib, regorafenib, pazopanib, nintedanib",0.0942041196321315,0,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",-0.42643,-1.06,0.389,957,0.791,"maxacalcitol, doxercalciferol, calcitriol",0.410050398674292,0.101823516502323,FALSE
+"H460","Pearson.est","EGFR inhibitor",0.66977,1.97,0.00714,148,0.223,"AZD8931, canertinib, BMS.690514, poziotinib, tucatinib, XL.647, lapatinib, neratinib, gefitinib, osimertinib, dacomitinib, PD.168393, afatinib, icotinib, erlotinib, vandetanib, tyrphostin.AG.494, ARRY.334543, pelitinib, brigatinib",2.14630178822383,0.651695136951839,TRUE
+"H460","Pearson.est","Abl kinase inhibitor",-0.27007,-0.657,0.882,852,1,"bosutinib, metatinib, GZD824, flumatinib, tozasertib, nilotinib, KW.2449",0.0545314148681803,0,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.38353,-0.931,0.577,603,0.921,"pilocarpine, nicotine, xanomeline, tremorine, oxiracetam",0.238824186844269,0.0357403698031511,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.30879,0.919,0.582,191,0.949,"darifenacin, iododexetimide",0.235077015350112,0.0227337875727074,FALSE
+"H460","Pearson.est","adenosine receptor antagonist",0.38977,1.18,0.232,65,0.745,"CGS.15943, MRS.1220",0.6345120151091,0.127843727251707,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",-0.23025,-0.564,0.953,1019,1,"midodrine, buphenine, norepinephrine, clenbuterol",0.0209070993616736,0,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",-0.45597,-1.09,0.355,1122,0.689,"idazoxan, oxprenolol, imiloxan, atipamezole, carvedilol, vincamine",0.449771646944906,0.161780778092374,FALSE
+"H460","Pearson.est","AKT inhibitor",0.34694,0.992,0.428,94,0.842,"GDC.0068, GSK2110183, MK.2206",0.368556230986828,0.0746879085003505,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.24846,0.744,0.75,5,0.97,"GW.788388",0.1249387366083,0.0132282657337552,FALSE
+"H460","Pearson.est","androgen receptor antagonist",-0.45317,-1.11,0.339,829,0.662,"RU.58841, cyproterone.acetate, nilutamide",0.469800301796918,0.1791420105603,FALSE
+"H460","Pearson.est","antioxidant",-0.626,-1.52,0.0438,970,0.314,"trolox, rutin, chlorogenic.acid, mesna, taurine",1.3585258894959,0.503070351926785,FALSE
+"H460","Pearson.est","AP inhibitor",-0.35833,-0.867,0.643,523,0.941,"tanshinone.i, idronoxil, GDC.0152, birinapant, LCL.161",0.191789027075778,0.0264103765727431,FALSE
+"H460","Pearson.est","ATPase inhibitor",-0.49737,-1.24,0.199,737,0.493,"thonzonium, ouabain, rabeprazole, blebbistatin...., NMS.873, oligomycin.a, evodiamine, digitoxigenin, digitoxin, digoxin",0.701146923590293,0.30715308072277,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.71095,-1.7,0.0151,1115,0.153,"CCT129202, PHA.680632, tozasertib, ZM.447439, barasertib.HQPA, alisertib, KW.2449, MLN.8054, MK.8745, barasertib, CCT137690, danusertib, ENMD.2076, MK.5108, AT.9283, AMG900, SNS.314, hesperadin, PF.03814735",1.82102305270683,0.815308569182401,TRUE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.374,-0.901,0.597,1155,0.941,"radezolid, valnemulin",0.224025668870631,0.0264103765727431,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.33707,-0.813,0.738,1370,0.935,"finafloxacin",0.131943638176958,0.0291883891274822,FALSE
+"H460","Pearson.est","BCL inhibitor",-0.48225,-1.18,0.253,1114,0.564,"venetoclax, gossypol, TW.37",0.596879478824182,0.248720896016658,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.29297,-0.71,0.832,762,0.985,"ponatinib, bosutinib, metatinib, GZD824, flumatinib, tozasertib, nilotinib",0.0798766737092761,0.00656376950238827,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.28436,0.798,0.684,129,0.936,"CL.218872, indiplon, piperazine",0.164943898279884,0.0287241512618947,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.45897,-1.12,0.315,681,0.659,"OTX015, JQ1...., I.BET.762, PFI.1, bromosporine",0.501689446210399,0.18111458540599,FALSE
+"H460","Pearson.est","calcium channel blocker",-0.21667,-0.526,0.967,633,1,"penfluridol, pranidipine, SR.33805, cinnarazine, tetrandrine, mibefradil, carboxyamidotriazole",0.0145735259169983,0,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.46912,-1.13,0.297,676,0.657,"RS.504393, UNBS.5162, PF.04136309, ZK811752, MK.0812, SB.225002, navarixin",0.527243550682788,0.182434630440219,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.56059,-1.37,0.1,869,0.353,"arcyriaflavin.a, dinaciclib, CR8..R., PHA.848125, aminopurvalanol.a, BMS.387032, JNJ.7706621, PHA.793887, alvocidib, kenpaullone, NU6027, TG.02, AZD5438, R547, BMS.265246, ribociclib, palbociclib, abemaciclib",1,0.452225294612177,FALSE
+"H460","Pearson.est","CHK inhibitor",-0.26895,-0.652,0.89,1199,0.992,"SB.218078",0.0506099933550872,0.00348832784582135,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.3881,-0.935,0.561,1132,0.937,"piroxicam, suxibuzone, ketoprofen, tepoxalin, FR.122047, indoprofen",0.251037138743839,0.0282604091122217,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",0.36711,1.15,0.25,919,0.57,"metyrapone, PF.4981517, eplerenone, morin, clotrimazole, itraconazole, cobicistat",0.602059991327962,0.244125144327509,FALSE
+"H460","Pearson.est","DNA alkylating agent",-0.62009,-1.49,0.051,1046,0.338,"streptozotocin, TH.302, carboplatin, carmustine, satraplatin, dianhydrogalactitol, melphalan, mitomycin.c",1.29242982390206,0.471083299722345,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.51302,-1.23,0.191,931,0.493,"tirapazamine, pibenzimol, mechlorethamine, primaquine, chlorambucil, carboplatin, carmustine, valrubicin, teroxirone, oxaliplatin, melphalan",0.718966632752272,0.30715308072277,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",0.29334,0.894,0.583,1025,0.928,"SGI.1027, azacitidine, fdcyd, disulfiram, RG108, decitabine",0.234331445240986,0.0324520237811379,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",-0.5996,-1.44,0.0673,1233,0.415,"foscarnet, trifluridine, idoxuridine",1.17198493577602,0.381951903287907,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.52475,-1.26,0.2,1277,0.467,"enocitabine, floxuridine, cyclocytidine, anisomycin, mitomycin.c",0.698970004336019,0.330683119433888,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",-0.34803,-0.837,0.681,793,0.953,"acetophenazine, thioproperazine, amisulpride, remoxipride, mesoridazine, isofloxythepin, sertindole, domperidone, oxiperomide, piperacetazine, raclopride, paliperidone, UH.232....",0.166852888087215,0.0209070993616736,FALSE
+"H460","Pearson.est","estrogen receptor agonist",0.3919,1.22,0.241,104,0.751,"levonorgestrel, ethinyl.estradiol, erteberel, equol",0.617982957425132,0.124360062995832,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",0.38053,1.16,0.238,260,0.613,"toremifene, tamoxifen, raloxifene, danazol",0.623423042943488,0.212539525481585,FALSE
+"H460","Pearson.est","FGFR inhibitor",-0.26343,-0.628,0.921,582,0.994,"orantinib, PD.173074, nintedanib, MK.2461, dovitinib, regorafenib",0.0357403698031511,0.00261361560268669,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.55936,-1.36,0.114,1014,0.336,"dovitinib, pacritinib, midostaurin, TG.101348, lestaurtinib, tozasertib, sunitinib, KW.2449, TG.02, ENMD.2076, quizartinib",0.943095148663527,0.473660722610156,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",0.21293,0.656,0.905,1145,1,"piretanide, triamcinolone.acetonide, dexamethasone.acetate, betamethasone, clobetasol.propionate, fludroxycortide, difluprednate, methylprednisolone, prednisolone.hemisuccinate, prednisolone.acetate, deflazacort, hydrocortisone, desonide, triamcinolone, flumethasone.pivalate, fluocinolone.acetonide, halcinonide, fluorometholone, ciclesonide, fluticasone.propionate, halobetasol.propionate, flumethasone, prednisolone, beclomethasone.dipropionate, rimexolone",0.0433514207947967,0,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",-0.19301,-0.467,0.987,1303,1,"ACDPP",0.00568284733036327,0,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",0.16817,0.494,0.985,1206,0.984,"CHIR.98014, CHIR.99021, LY2090314, AZD2858, indirubin, GSK.3.inhibitor.IX, TWS.119, tideglusib, kenpaullone",0.00656376950238827,0.00700490156865849,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.57027,-1.38,0.1,1138,0.374,"lestaurtinib, GSK1838705A, danusertib, AZD3463",1,0.42712839779952,FALSE
+"H460","Pearson.est","HCV inhibitor",-0.67933,-1.62,0.0129,1332,0.203,"narlaprevir, mericitabine",1.88941028970075,0.692503962086787,TRUE
+"H460","Pearson.est","HDAC inhibitor",-0.34307,-0.837,0.656,897,0.953,"R306465, belinostat, resminostat, scriptaid, AR.42, trichostatin.a, PCI.24781, RG2833, entinostat, givinostat, dacinostat, SB.939",0.18309616062434,0.0209070993616736,FALSE
+"H460","Pearson.est","histamine receptor antagonist",-0.2111,-0.512,0.966,1345,1,"pheniramine, tiotidine",0.0150228735845067,0,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.46879,1.35,0.136,772,0.571,"lovastatin, pitavastatin, simvastatin, fluvastatin, atorvastatin, mevastatin",0.866461091629782,0.243363891754152,FALSE
+"H460","Pearson.est","HSP inhibitor",-0.50421,-1.21,0.229,1272,0.518,"SNX.2112, ganetespib, NVP.AUY922, PU.H71, tanespimycin",0.640164517660112,0.285670240254767,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.53356,-1.27,0.18,1050,0.467,"TG.101209, PRT062070, pacritinib, TG.101348, WHI.P154, lestaurtinib, tozasertib, AZ960, TG.02, filgotinib, AT.9283",0.744727494896694,0.330683119433888,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.36422,-0.884,0.624,1078,0.953,"OSI.930, midostaurin, sunitinib, regorafenib, vatalanib, KI.8751",0.204815410317576,0.0209070993616736,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.74823,-1.83,0.0071,1217,0.227,"RITA, idasanutlin, CGM097, nutlin.3, serdemetan",2.14874165128092,0.643974142806877,TRUE
+"H460","Pearson.est","MEK inhibitor",-0.54398,-1.31,0.143,1110,0.408,"MEK162, AS.703026, AZD8330, PD.0325901, PD.198306, selumetinib, arctigenin, TAK.733, PD.318088, Ro.4987655, PD.184352, nobiletin",0.844663962534938,0.38933983691012,FALSE
+"H460","Pearson.est","MET inhibitor",0.45839,1.4,0.126,787,0.574,"INC.280, NVP.BVU972, PF.04217903, AMG458, LY2801653, PHA.665752",0.899629454882437,0.241088107602027,FALSE
+"H460","Pearson.est","microtubule inhibitor",-0.73347,-1.78,0.00473,1255,0.0942,"cabazitaxel, secnidazole, podophyllotoxin, D.64131, vinflunine, vinblastine",2.32513885926219,1.02594909720712,TRUE
+"H460","Pearson.est","mTOR inhibitor",-0.36299,-0.877,0.623,663,0.944,"torin.2, palomid.529, sirolimus, PI.103, voxtalisib, SB.2343, LY303511, WAY.600, PKI.179, AZD2014, AZD8055, NVP.BEZ235, PP242, XL388, deforolimus, torin.1, MLN0128, WYE.354, ku.0063794",0.20551195334083,0.025028005701931,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",0.28691,0.848,0.625,1036,0.895,"bindarit, parthenolide...., tyloxapol, curcumin, BAY.11.7085, IKK.2.inhibitor.V, BAY.11.7082, bortezomib, Ro.106.9920, parthenolide, betulinic.acid, EVP4593",0.204119982655925,0.048176964684088,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.64839,-1.57,0.0301,1097,0.253,"cebranopadol, spiradoline, salvinorin.a, trimebutine",1.52143350440616,0.596879478824182,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",0.37266,1.16,0.271,911,0.613,"talmapimod, TAK.715, VX.702, SB.239063, CMPD.1, SB.242235, skepinone.l",0.567030709125594,0.212539525481585,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.74241,-1.8,0.00703,1101,0.106,"AG.14361, niraparib, PJ.34, olaparib, E7449, AZD2461, talazoparib",2.15304467498018,0.97469413473523,TRUE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.32057,-0.768,0.783,948,0.965,"CP.673451, axitinib, dovitinib, trapidil, SU014813, sunitinib, regorafenib, vatalanib, crenolanib, KI.8751",0.106238237942057,0.0154726866562074,FALSE
+"H460","Pearson.est","phosphatase inhibitor",-0.18902,-0.455,0.993,1107,0.99,"bis.maltolato.oxovanadium.IV., GSK2830371",0.00305075150461883,0.00436480540245009,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",-0.29501,-0.715,0.823,778,0.998,"anagrelide, YM.976, zardaverine, EMD.53998, GSK256066",0.0846001647877302,0.000869458712628891,FALSE
+"H460","Pearson.est","PI3K inhibitor",0.21516,0.645,0.876,138,0.99,"TG100.115, taselisib, alpelisib, buparlisib, PI3K.IN.2, PI.828, pilaralisib",0.0574958938319193,0.00436480540245009,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.75573,-1.82,0.00117,1089,0.124,"GW.843682X, NMS.1286937, BI.2536, GSK461364, HMN.214, rigosertib, volasertib",2.93181413825384,0.906578314837765,TRUE
+"H460","Pearson.est","potassium channel blocker",-0.42649,-1.03,0.443,615,0.787,"mepivacaine, dofetilide, meglitinide, oleoylethanolamide, ibutilide, ML133",0.35359627377693,0.104025267640935,FALSE
+"H460","Pearson.est","PPAR receptor agonist",-0.39634,-0.954,0.549,934,0.919,"oleoylethanolamide, clofibrate, ciprofibrate, GW.501516",0.260427655549908,0.0366844886138887,FALSE
+"H460","Pearson.est","progesterone receptor agonist",-0.33588,-0.819,0.728,1159,0.945,"tanaproget, dienogest",0.137868620686963,0.0245681914907371,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.29167,0.867,0.59,1028,0.922,"delanzomib, ONX.0914, carfilzomib, oprozomib, ixazomib.citrate, bortezomib, MG.132, ixazomib",0.229147988357856,0.0352690789463706,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.58105,-1.43,0.093,1265,0.404,"emetine, cycloheximide, mercaptopurine, harringtonine, bruceantin, anguidine, homoharringtonine",1.03151705144606,0.393618634889395,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.43293,-1.04,0.417,952,0.787,"tyrphostin.A9, mubritinib, NVP.TAE226",0.379863945026242,0.104025267640935,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.58609,-1.42,0.0886,899,0.394,"CEP.32496, SB.590885, vemurafenib, PLX.4720, TAK.632, AZ.628, regorafenib, LGX818, RAF265, dabrafenib, GDC.0879",1.05256627811295,0.404503778174426,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.37626,-0.915,0.574,1007,0.933,"cabozantinib, sunitinib, regorafenib",0.241088107602027,0.0301183562535,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.32481,-0.79,0.751,1381,0.95,"adarotene",0.124360062995832,0.0222763947111523,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.57427,-1.39,0.0957,1051,0.403,"fludarabine, gemcitabine, triapine, cladribine, LY2334737, clofarabine",1.01908806222316,0.39469495385889,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.58604,-1.4,0.095,1447,0.408,"aripiprazole",1.02227639471115,0.38933983691012,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.57541,-1.38,0.087,1374,0.374,"paliperidone, SB.200646, aripiprazole",1.06048074738138,0.42712839779952,FALSE
+"H460","Pearson.est","sodium channel blocker",-0.41985,-1.02,0.441,867,0.788,"quinidine, butamben, mexiletine, ajmaline, benzethonium, A.803467, triamterene",0.355561410532161,0.103473782510445,FALSE
+"H460","Pearson.est","src inhibitor",0.47523,1.43,0.0867,117,0.678,"saracatinib, dasatinib, ZM.306416, PP.1",1.06198090252379,0.168770306132937,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.33845,-0.827,0.711,751,0.95,"lanoconazole, chlormidazole, ketoconazole",0.148130399270234,0.0222763947111523,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",0.52966,1.6,0.0494,213,0.553,"LY2109761, repsox, D.4476, SB.431542",1.30627305107635,0.257274868695302,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.55687,-1.36,0.105,803,0.336,"capecitabine, ftorafur, doxifluridine, trifluridine, carmofur, raltitrexed",0.978810700930062,0.473660722610156,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.56549,-1.37,0.105,1070,0.353,"irinotecan, mitoxantrone, doxorubicin, topotecan, rubitecan, dexrazoxane, genz.644282, valrubicin, nemorubicin, daunorubicin, voreloxin, idarubicin, teniposide, amsacrine, amonafide, TAS.103",0.978810700930062,0.452225294612177,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.67938,-1.66,0.0164,992,0.18,"mebendazole, indibulin, fenbendazole, epothilone.d, paclitaxel, flubendazole, nocodazole, plinabulin, vindesine, vincristine, KX2.391, docetaxel, vinorelbine, podophyllotoxin, CYT.997, ABT.751, parbendazole, dolastatin.10, albendazole, vinblastine, BNC105, epothilone.b, verubulin, combretastatin.A.4, fosbretabulin, taltobulin",1.7851561519523,0.744727494896694,TRUE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.3094,-0.76,0.778,901,0.957,"tivantinib, aminopurvalanol.a, tyrphostin.A9, mubritinib, AMG.208, cabozantinib, sunitinib, regorafenib, NVP.TAE226, UNC2250",0.109020403010311,0.0190880622231565,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.27627,-0.662,0.885,991,1,"axitinib, cabozantinib, dovitinib, OSI.930, TG.100572, SU014813, sunitinib, regorafenib, SAR131675, vatalanib, ENMD.2076, RAF265, KI.8751",0.0530567293021746,0,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",0.20472,0.637,0.917,1153,0.948,"maxacalcitol, calcitriol, alfacalcidol, paricalcitol, tacalcitol, ercalcitriol, doxercalciferol",0.0376306643299789,0.0231916626619338,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.8553,2.37,0,86,0.00903,"AZD8931, poziotinib, XL.647, canertinib, gefitinib, neratinib, lapatinib, dacomitinib, BMS.690514, osimertinib, erlotinib, tucatinib, CUDC.101, afatinib, ARRY.334543, vandetanib, BMS.599626, PD.168393, pelitinib, icotinib, WZ8040, AST.1306, BIBU.1361, PD.153035, CP.724714, AEE788, WZ.4002, rociletinib",Inf,2.04431224968649,TRUE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.28354,-0.663,0.881,1087,1,"flumatinib, KW.2449, tozasertib, nilotinib, GZD824",0.0550240915879521,0,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.45459,-1.06,0.401,1183,0.822,"xanomeline, oxiracetam",0.396855627379818,0.0851281824599496,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",-0.50474,-1.19,0.25,1191,0.685,"methscopolamine, iododexetimide",0.602059991327962,0.164309428507574,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",0.63192,1.78,0.0453,130,0.121,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",1.34390179798717,0.91721462968355,TRUE
+"H1299","Pearson.est","adrenergic receptor agonist",0.26518,0.722,0.791,1068,0.973,"isoxsuprine, methyldopa, oxymetazoline, isoetharine, ritodrine, norepinephrine, metaraminol, terbutaline, epinephrine, xylazine, A61603, buphenine, clenbuterol, lidamidine, midodrine",0.101823516502323,0.0118871597316481,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",-0.33515,-0.794,0.741,962,0.986,"metoprolol, pindolol, oxprenolol, atipamezole, vincamine, idazoxan, carvedilol",0.130181792020672,0.0061230850587888,FALSE
+"H1299","Pearson.est","AKT inhibitor",0.48453,1.38,0.119,239,0.361,"GDC.0068, uprosertib, CCT128930, GSK2110183, AZD5363, triciribine",0.924453038607469,0.442492798094342,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.29576,0.835,0.679,1023,0.998,"GW.788388, brigatinib, SB.505124, NVP.TAE684, CEP.37440, alectinib, AZD3463, AP26113, crizotinib, DMH1, lorlatinib",0.168130225719498,0.000869458712628891,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",-0.34817,-0.829,0.696,592,1,"cyproterone.acetate, RU.58841, bicalutamide, flutamide, nilutamide",0.157390760389438,0,FALSE
+"H1299","Pearson.est","antioxidant",0.5215,1.49,0.102,696,0.32,"mesna, taurine, trolox, rutin, chlorogenic.acid, benfotiamine",0.991399828238082,0.494850021680094,FALSE
+"H1299","Pearson.est","AP inhibitor",-0.55903,-1.3,0.153,911,0.578,"LCL.161, birinapant, GDC.0152, idronoxil",0.815308569182401,0.238072161579471,FALSE
+"H1299","Pearson.est","ATPase inhibitor",-0.69374,-1.62,0.0181,1126,0.227,"evodiamine, k.strophanthidin, digitoxin, ouabain, NMS.873, thonzonium, digitoxigenin, oligomycin.a, digoxin",1.74232142513082,0.643974142806877,TRUE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.6313,-1.47,0.0553,1035,0.368,"TAK.901, aurora.a.inhibitor.i, GSK1070916, alisertib, ZM.447439, KW.2449, tozasertib, barasertib.HQPA, CCT137690, hesperadin, MK.8745, AT.9283, barasertib, PF.03814735, AMG900, danusertib, MK.5108, SNS.314",1.2572748686953,0.434152181326482,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30898,-0.73,0.817,985,0.996,"josamycin, radezolid, valnemulin",0.0877779434675845,0.00174066157630127,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.33572,-0.795,0.716,727,1,"sparfloxacin, sarafloxacin, trovafloxacin, norfloxacin, novobiocin, lomefloxacin",0.145086977692144,0,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.40199,-0.939,0.553,1142,0.9,"gossypol, TW.37",0.257274868695302,0.0457574905606751,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.33095,-0.767,0.779,787,0.986,"metatinib, bafetinib, ponatinib, flumatinib, tozasertib, nilotinib, GZD824",0.108462542327436,0.0061230850587888,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.28502,0.8,0.7,1039,1,"CL.218872, gamma.aminobutyric.acid, piperazine, nefiracetam, eprinomectin, lorazepam, bentazepam, zaleplon, CGS.20625, indiplon, ZK.93423, temazepam, ivermectin",0.154901959985743,0,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",-0.40445,-0.95,0.55,610,0.902,"I.BET151, OTX015, PFI.1, bromosporine",0.259637310505756,0.0447934624580583,FALSE
+"H1299","Pearson.est","calcium channel blocker",-0.36853,-0.876,0.641,938,0.958,"pranidipine, SR.33805, penfluridol, carboxyamidotriazole",0.193141970481183,0.0186344909214556,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.59519,-1.37,0.111,912,0.545,"RS.504393, PF.04136309, MK.0812, SB.225002, UNBS.5162",0.954677021213343,0.263603497723358,FALSE
+"H1299","Pearson.est","CDK inhibitor",-0.28394,-0.666,0.875,815,1,"JNJ.7706621, AZD5438, palbociclib, kenpaullone, PHA.848125, dinaciclib, R547, BMS.387032, indisulam, BMS.265246, abemaciclib, PHA.793887",0.0579919469776868,0,FALSE
+"H1299","Pearson.est","CHK inhibitor",-0.42873,-1.01,0.469,1184,0.839,"LY2606368, PF.477736",0.328827157284917,0.0762380391712997,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",-0.32707,-0.757,0.817,849,0.98,"metoxibutropate, sulfasalazine, FR.122047, ketoprofen, indoprofen, piroxicam, naproxen, AM.404, suxibuzone, tepoxalin",0.0877779434675845,0.00877392430750515,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",-0.47519,-1.11,0.339,1016,0.752,"clotrimazole, cobicistat, metyrapone",0.469800301796918,0.123782159408358,FALSE
+"H1299","Pearson.est","DNA alkylating agent",-0.44138,-1.04,0.438,1157,0.818,"TH.302, satraplatin, carboplatin, cisplatin, dianhydrogalactitol, melphalan",0.3585258894959,0.087246696328677,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.40894,-0.978,0.51,954,0.888,"teroxirone, tirapazamine, pibenzimol, carboplatin, valrubicin, melphalan, chlorambucil",0.292429823902064,0.051587034221399,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",0.32605,0.927,0.517,170,0.925,"azacitidine, fdcyd",0.286509456906058,0.0338582672609674,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",-0.38664,-0.906,0.584,737,0.92,"foscarnet, menadione, adefovir.dipivoxil, trifluridine, idoxuridine, cephalomannine",0.233587152887601,0.0362121726544447,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",-0.54103,-1.29,0.149,1065,0.569,"azodicarbonamide, cyclocytidine, enocitabine, artesunate, CB.10.277, cisplatin, anisomycin, artemisinin",0.826813731587726,0.244887733604929,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",0.20958,0.571,0.941,229,0.997,"lurasidone, clebopride, ziprasidone, domperidone, mesoridazine, remoxipride, acetophenazine",0.0264103765727431,0.00130484168834428,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",0.27778,0.785,0.665,1048,0.922,"erteberel, levonorgestrel, ethinyl.estradiol, equol, estradiol.cypionate, PPT, estrone, estradiol",0.177178354696895,0.0352690789463706,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.34811,-0.825,0.698,1112,1,"fulvestrant, toremifene",0.156144577376839,0,FALSE
+"H1299","Pearson.est","FGFR inhibitor",-0.48127,-1.13,0.32,1050,0.727,"MK.2461, dovitinib, nintedanib, erdafitinib, regorafenib",0.494850021680094,0.138465589140962,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.49651,-1.16,0.299,1043,0.705,"lestaurtinib, dovitinib, TG.101348, KW.2449, tozasertib, tyrphostin.AG.1296, midostaurin, quizartinib, sorafenib",0.52432881167557,0.151810883008601,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",0.22069,0.6,0.94,343,1,"triamcinolone.acetonide, hydrocortisone, ciclesonide, fludroxycortide, desonide, methylprednisolone, betamethasone, fluocinolone.acetonide, flumethasone, flumethasone.pivalate, difluprednate, dexamethasone.acetate, clobetasol.propionate",0.0268721464003014,0,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.37983,1.07,0.368,188,0.732,"diazooxonorleucine, latrepirdine, CGP.37849, kynurenic.acid, SIB.1757",0.434152181326482,0.135488918941608,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.26609,-0.615,0.915,908,0.969,"kenpaullone, TWS.119, GSK.3.inhibitor.IX, AZD2858, tideglusib",0.0385789059335517,0.0136762229492347,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",-0.38734,-0.914,0.589,914,0.928,"GSK1838705A, PHA.848125, lestaurtinib, danusertib",0.229884705212898,0.0324520237811379,FALSE
+"H1299","Pearson.est","HCV inhibitor",-0.65863,-1.55,0.0227,1133,0.321,"Ro.9187, mericitabine, narlaprevir",1.64397414280688,0.493494967595128,FALSE
+"H1299","Pearson.est","HDAC inhibitor",-0.29847,-0.701,0.859,660,1,"nexturastat.a, NSC.3852, M.344, R306465, ACY.1215, SB.939, trichostatin.a, resminostat, givinostat, AR.42, RG2833, scriptaid, dacinostat, chidamide, entinostat, belinostat",0.0660068361687577,0,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",-0.25626,-0.603,0.928,1121,0.945,"ICI.162846, nizatidine, cimetidine, tiotidine",0.0324520237811379,0.0245681914907371,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",-0.85383,-2.03,0,1420,0.0101,"mevastatin, pitavastatin, fluvastatin, atorvastatin",Inf,1.99567862621736,TRUE
+"H1299","Pearson.est","HSP inhibitor",-0.63124,-1.5,0.0486,1241,0.386,"BIIB021, PU.H71, ganetespib, SNX.2112, NVP.AUY922, NMS.E973",1.31336373073771,0.413412695328245,FALSE
+"H1299","Pearson.est","JAK inhibitor",-0.34295,-0.803,0.737,1043,1,"lestaurtinib, AZ960, TG.101348, tozasertib, PRT062070, AT.9283",0.132532512140949,0,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.50271,-1.18,0.287,1010,0.681,"telatinib, OSI.930, motesanib, cediranib, vatalanib, midostaurin, KI.8751, sorafenib, pazopanib, regorafenib",0.542118103266008,0.166852888087215,FALSE
+"H1299","Pearson.est","MDM inhibitor",-0.24383,-0.574,0.938,1202,0.948,"serdemetan",0.0277971616209356,0.0231916626619338,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.65261,1.79,0.0286,189,0.194,"trametinib, AS.703026, selumetinib, cobimetinib, AZD8330, PD.0325901, TAK.733, Ro.4987655, MEK162, MEK1.2.inhibitor, PD.318088, PD.198306",1.54363396687096,0.712198270069774,TRUE
+"H1299","Pearson.est","MET inhibitor",-0.26184,-0.613,0.931,946,0.954,"AMG458, PHA.665752, LY2801653",0.0310503190186574,0.0204516252959049,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.73203,-1.71,0.00765,1274,0.12,"D.64131, podophyllotoxin, secnidazole, cabazitaxel, vinflunine, vinblastine",2.11633856484638,0.920818753952375,TRUE
+"H1299","Pearson.est","mTOR inhibitor",0.18822,0.51,0.991,981,0.982,"GSK2126458, GDC.0980, WAY.600, WYE.125132, LY303511, voxtalisib, PP242, XL388, OSI.027, PI.103, PF.04691502, torin.2, SB.2343, WYE.354, everolimus, AZD2014, palomid.529, torin.1, AZD8055, temsirolimus, MLN0128, PF.05212384, ku.0063794, NVP.BEZ235, sirolimus, PKI.179, LY3023414",0.00392634551472468,0.00788851221305034,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.3243,-0.768,0.758,788,1,"BAY.11.7082, betulinic.acid, bortezomib, parthenolide, IKK.2.inhibitor.V, EVP4593",0.120330794367946,0,FALSE
+"H1299","Pearson.est","opioid receptor agonist",-0.41169,-0.954,0.543,828,0.918,"cebranopadol, salvinorin.a, trimebutine, spiradoline",0.265200170411153,0.0371573187987575,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",0.53019,1.46,0.0933,684,0.301,"SB.239063, talmapimod, SB.242235, TAK.715, skepinone.l, VX.702, CMPD.1",1.0301183562535,0.521433504406157,FALSE
+"H1299","Pearson.est","PARP inhibitor",-0.52559,-1.25,0.215,917,0.612,"E7449, AG.14361, olaparib, AZD2461, talazoparib",0.667561540084395,0.213248577854439,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49134,-1.15,0.292,1010,0.703,"telatinib, motesanib, dovitinib, SU014813, nintedanib, trapidil, vatalanib, crenolanib, axitinib, CP.673451, KI.8751, sorafenib, pazopanib, regorafenib",0.534617148551582,0.153044674980176,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.43489,-1.02,0.445,1117,0.84,"BVT.948, CID.5458317, GSK2830371, bis.maltolato.oxovanadium.IV.",0.351639989019068,0.0757207139381184,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",-0.27589,-0.654,0.889,974,1,"papaverine, zardaverine, YM.976, GSK256066",0.0510982390297863,0,FALSE
+"H1299","Pearson.est","PI3K inhibitor",0.37286,1.06,0.365,124,0.692,"alpelisib, taselisib, GSK2126458, CH5132799, PI.828, GDC.0980",0.437707135543525,0.159893905543242,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.78765,-1.84,0.00382,1135,0.054,"GW.843682X, HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib",2.41793663708829,1.26760624017703,TRUE
+"H1299","Pearson.est","potassium channel blocker",-0.55774,-1.32,0.133,879,0.602,"ibutilide, meglitinide, mepivacaine, dofetilide",0.876148359032914,0.220403508742175,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",-0.44533,-1.05,0.406,839,0.82,"ciprofibrate, clofibrate, GW.501516",0.391473966422806,0.0861861476162833,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.26273,-0.618,0.945,895,0.984,"norgestrel, dienogest, norethindrone, tanaproget",0.0245681914907371,0.00700490156865849,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.53586,-1.24,0.21,878,0.609,"bortezomib, ONX.0914, carfilzomib, delanzomib, MG.132, ixazomib",0.677780705266081,0.215382707367125,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.55341,-1.26,0.17,1176,0.617,"cycloheximide, bruceantin, puromycin, thiostrepton, harringtonine, mercaptopurine, homoharringtonine, anguidine",0.769551078621726,0.209714835966758,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.47486,1.25,0.162,143,0.459,"BMS.599626, AV.412, CP.724714, NVP.TAE226",0.790484985457369,0.338187314462739,FALSE
+"H1299","Pearson.est","RAF inhibitor",-0.61097,-1.43,0.0728,1266,0.427,"PLX.4720, TAK.632, RAF265, sorafenib, regorafenib",1.13786862068696,0.369572124974976,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.45603,-1.06,0.395,1351,0.822,"sorafenib, regorafenib",0.40340290437354,0.0851281824599496,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",0.3445,0.918,0.557,56,0.878,"CD.437, tamibarotene",0.254144804826271,0.0565054840938974,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.62492,-1.49,0.0442,944,0.364,"fludarabine, hydroxyurea, LY2334737, fludarabine.phosphate, triapine, pentostatin, gemcitabine, cladribine, clofarabine",1.35457773065091,0.438898616350944,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",-0.55265,-1.3,0.14,1294,0.578,"pardoprunox, aripiprazole",0.853871964321762,0.238072161579471,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",-0.51825,-1.21,0.251,1320,0.659,"paliperidone, lerisetron, aripiprazole",0.600326278518962,0.18111458540599,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.55743,-1.32,0.133,994,0.602,"butamben, quinidine, mepivacaine, brivaracetam, triamterene, benzethonium, cibenzoline",0.876148359032914,0.220403508742175,FALSE
+"H1299","Pearson.est","src inhibitor",0.63965,1.78,0.0415,36,0.121,"saracatinib, dasatinib, ZM.306416",1.38195190328791,0.91721462968355,TRUE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.2768,-0.649,0.882,740,0.992,"lanoconazole, ketoconazole, posaconazole, chlormidazole",0.0545314148681803,0.00348832784582135,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",0.494,1.32,0.18,234,0.399,"repsox, LY2109761, SB.431542",0.744727494896694,0.399027104313252,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",0.23509,0.611,0.935,1109,1,"carmofur, capecitabine, ftorafur, doxifluridine, raltitrexed, trifluridine",0.0291883891274822,0,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.78678,-1.84,0,1228,0.054,"genz.644282, dexrazoxane, SN.38, amonafide, amsacrine, nemorubicin, valrubicin, irinotecan, idarubicin, voreloxin, mitoxantrone, rubitecan, doxorubicin, TAS.103, epirubicin, etoposide, etoposide.phosphate, daunorubicin, teniposide, topotecan",Inf,1.26760624017703,TRUE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.75495,-1.78,0.00251,1111,0.0757,"flubendazole, parbendazole, mebendazole, epothilone.b, albendazole, plinabulin, fosbretabulin, epothilone.d, fenbendazole, ABT.751, vinorelbine, dolastatin.10, podophyllotoxin, KX2.391, paclitaxel, CYT.997, docetaxel, combretastatin.A.4, vincristine, vindesine, verubulin, taltobulin, BNC105, vinblastine",2.60032627851896,1.12090412049993,TRUE
+"H1299","Pearson.est","tyrosine kinase inhibitor",0.28712,0.794,0.766,69,0.961,"vandetanib, BMS.599626, dasatinib, AV.412, CP.724714",0.115771230367396,0.0172766123314547,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.26478,-0.632,0.899,1045,0.99,"OSI.930, MK.2461, motesanib, dovitinib, cediranib, SU014813, SAR131675, nintedanib, vatalanib, tivozanib, axitinib, KI.8751, RAF265, sorafenib, pazopanib, regorafenib",0.0462403082667712,0.00436480540245009,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.71111,1.95,0.00476,324,0.132,"maxacalcitol, paricalcitol, tacalcitol, calcitriol, ercalcitriol, alfacalcidol",2.32239304727951,0.87942606879415,TRUE
+"HCC44","Pearson.est","EGFR inhibitor",-0.77667,-1.87,0.0105,1319,0.13,"rociletinib, ARRY.334543, TAK.285, BIBU.1361, WZ8040, BMS.690514, vandetanib, CUDC.101, BMS.599626, PD.153035, AST.1306, PD.168393, canertinib, icotinib, osimertinib, lapatinib, neratinib, pelitinib, dacomitinib, afatinib, AZD8931, gefitinib, erlotinib, XL.647, poziotinib",1.97881070093006,0.886056647693163,TRUE
+"HCC44","Pearson.est","Abl kinase inhibitor",-0.63537,-1.53,0.0623,1344,0.705,"ZM.306416, bosutinib, dasatinib",1.20551195334083,0.151810883008601,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",0.32455,0.834,0.633,980,0.927,"nefiracetam, nicotine, oxiracetam, tremorine, xanomeline, pilocarpine",0.198596289982645,0.0329202658555029,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",0.74645,1.98,0.00484,141,0.0671,"iododexetimide, diphemanil, darifenacin",2.31515463835559,1.17327747983101,TRUE
+"HCC44","Pearson.est","adenosine receptor antagonist",-0.44804,-1.09,0.35,1126,0.821,"SCH.58261, PSB.1115, CGS.15943",0.455931955649724,0.0856568428805592,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",0.21407,0.569,0.942,33,0.969,"xylazine",0.0259490972071227,0.0136762229492347,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",0.35932,0.931,0.504,207,0.833,"metoprolol, pindolol, propranolol, oxprenolol, practolol",0.297569463554475,0.0793549985932124,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.36686,-0.894,0.561,1151,0.945,"uprosertib, AT7867, triciribine",0.251037138743839,0.0245681914907371,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.21412,0.57,0.947,317,0.995,"DMH1, CEP.37440, NVP.TAE684",0.0236500209967266,0.00217691925427455,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",0.43812,1.12,0.304,201,0.712,"flutamide, enzalutamide",0.517126416391246,0.147520006363144,FALSE
+"HCC44","Pearson.est","antioxidant",-0.41309,-0.994,0.444,1376,0.915,"mesna",0.35261702988538,0.0385789059335517,FALSE
+"HCC44","Pearson.est","AP inhibitor",0.20943,0.541,0.956,1146,0.963,"idronoxil, embelin, GDC.0152, LCL.161, tanshinone.i, birinapant",0.0195421077238999,0.0163737128754655,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",0.35126,0.909,0.541,278,0.844,"oligomycin.a, rabeprazole, omeprazole, digoxin",0.266802734893431,0.073657553374345,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.31203,-0.766,0.744,879,1,"PF.03814735, CCT129202, PHA.680632, MLN.8054, MK.8745, danusertib, CYC116, hesperadin, ENMD.2076, MK.5108, alisertib, GSK1070916",0.128427064454121,0,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.56313,-1.4,0.127,983,0.44,"radezolid, azalomycin.b, valnemulin, tilmicosin, azithromycin, tedizolid",0.896196279044043,0.356547323513813,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.38464,-0.942,0.538,1305,0.913,"lomefloxacin, finafloxacin",0.269217724333611,0.039529222465701,FALSE
+"HCC44","Pearson.est","BCL inhibitor",0.41904,1.09,0.33,77,0.73,"ABT.737, oridonin",0.481486060122112,0.136677139879544,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.61142,-1.51,0.0597,1374,0.447,"bosutinib, dasatinib",1.22402566887063,0.349692476868064,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",0.37599,1,0.442,383,0.801,"indiplon, nefiracetam, bentazepam, temazepam, gamma.aminobutyric.acid, piperazine",0.354577730650908,0.0963674839157623,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",0.66177,1.72,0.0203,144,0.323,"PFI.1, I.BET151",1.69250396208679,0.490797477668897,FALSE
+"HCC44","Pearson.est","calcium channel blocker",0.29237,0.752,0.756,216,1,"fendiline, SR.33805, pranidipine",0.121478204498793,0,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.36492,-0.889,0.602,1193,0.922,"RS.504393, navarixin, ZK811752",0.220403508742175,0.0352690789463706,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.59206,-1.42,0.103,1144,0.441,"BMS.387032, dinaciclib, BMS.265246, P276.00, JNJ.7706621, PHA.848125, aminopurvalanol.a, AT.7519, alvocidib, AZD5438",0.987162775294828,0.355561410532161,FALSE
+"HCC44","Pearson.est","CHK inhibitor",-0.61325,-1.52,0.0633,1122,0.595,"LY2606368, SCH.900776, AZD7762, CHIR.124, LY2603618",1.19859628998265,0.22548303427145,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",0.36084,0.942,0.495,211,0.846,"naproxen, sulfasalazine, tepoxalin, pterostilbene, AM.404, metoxibutropate, suxibuzone",0.305394801066431,0.0726296369609765,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.2556,-0.617,0.887,1205,1,"eplerenone, itraconazole",0.0520763801682736,0,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",0.23654,0.621,0.891,15,0.979,"dianhydrogalactitol",0.0501222959631252,0.00921730819686218,FALSE
+"HCC44","Pearson.est","DNA inhibitor",0.29091,0.758,0.737,169,1,"chlorambucil, pibenzimol, bendamustine",0.132532512140949,0,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.53214,-1.31,0.174,1371,0.481,"azacitidine, decitabine",0.7594507517174,0.317854923626168,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.34445,-0.827,0.683,893,0.944,"foscarnet, idoxuridine, trifluridine, cephalomannine, adefovir.dipivoxil, cidofovir",0.165579296318467,0.025028005701931,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",0.2788,0.728,0.824,183,0.955,"artemisinin, azodicarbonamide, nelarabine, estramustine.phosphate",0.0840727883028842,0.0199966284162537,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.23435,-0.572,0.943,982,1,"oxiperomide, domperidone, UH.232...., mesoridazine, clebopride, piperacetazine, acetophenazine",0.0254883072626717,0,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",0.24343,0.632,0.88,177,0.995,"equol, estradiol.cypionate",0.0555173278498314,0.00217691925427455,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",0.61534,1.6,0.0685,74,0.393,"toremifene, danazol",1.16430942850757,0.405607449624573,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",0.61005,1.56,0.0835,302,0.348,"erdafitinib, nintedanib, lenvatinib, dovitinib, regorafenib, orantinib",1.0783135245164,0.458420756053419,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",0.29026,0.721,0.779,218,0.935,"TG.101348, dovitinib, sorafenib, sunitinib",0.108462542327436,0.0291883891274822,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.47051,-1.15,0.31,1019,0.73,"prednisolone.acetate, rimexolone, flumethasone.pivalate, flumethasone, halobetasol.propionate, ciclesonide, dexamethasone.acetate, desonide, methylprednisolone, triamcinolone.acetonide, fluocinolone.acetonide, hydrocortisone",0.508638306165727,0.136677139879544,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",0.28545,0.728,0.798,371,0.955,"felbamate, IEM1754, MTPG, ACDPP, CPP, LY456236",0.0979971086492706,0.0199966284162537,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.17152,-0.413,0.99,938,1,"kenpaullone, TWS.119, indirubin, LY2090314",0.00436480540245009,0,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.4931,-1.19,0.273,973,0.684,"AZD3463, danusertib, GSK1838705A, PHA.848125, GSK1904529A",0.563837352959244,0.164943898279884,FALSE
+"HCC44","Pearson.est","HCV inhibitor",0.4741,1.24,0.227,43,0.606,"narlaprevir",0.643974142806877,0.217527375833714,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",-0.12509,-0.302,1,178,1,"ACY.1215, scriptaid, mocetinostat, vorinostat, nexturastat.a, RG2833, entinostat, R306465, M.344, SB.939, resminostat, pyroxamide, JNJ.26481585, PCI.24781, RGFP966, chidamide, NSC.3852, dacinostat, trichostatin.a, AR.42, belinostat, tacedinaline, panobinostat, givinostat, romidepsin",0,0,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",-0.29786,-0.717,0.795,1020,1,"zolantidine, pheniramine, astemizole, terfenadine, levocetirizine, ebastine, ranitidine",0.0996328713435297,0,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",0.77078,2.01,0.00726,82,0.0758,"mevastatin, pitavastatin, atorvastatin",2.13906337929991,1.12033079436795,TRUE
+"HCC44","Pearson.est","HSP inhibitor",-0.60212,-1.45,0.0864,1228,0.419,"XL888, SNX.2112, ganetespib, PU.H71, NVP.AUY922, SNX.5422, BIIB021",1.06348625752111,0.377785977033705,FALSE
+"HCC44","Pearson.est","JAK inhibitor",-0.24363,-0.591,0.934,1136,1,"CEP.33779, baricitinib, WHI.P154, filgotinib",0.0296531237699066,0,FALSE
+"HCC44","Pearson.est","KIT inhibitor",0.34529,0.903,0.528,267,0.823,"pazopanib, motesanib, lenvatinib, sorafenib, sunitinib, masitinib, regorafenib, telatinib",0.277366077466188,0.0846001647877302,FALSE
+"HCC44","Pearson.est","MDM inhibitor",0.51852,1.35,0.15,443,0.598,"AMG.232, CGM097, serdemetan, nutlin.3, idasanutlin",0.823908740944319,0.223298816011589,FALSE
+"HCC44","Pearson.est","MEK inhibitor",-0.76889,-1.89,0.0106,1339,0.213,"PD.184352, PD.318088, cobimetinib, TAK.733, PD.0325901, Ro.4987655, refametinib, selumetinib, AS.703026, AZD8330, trametinib",1.97469413473523,0.671620396561262,TRUE
+"HCC44","Pearson.est","MET inhibitor",-0.41253,-1.01,0.449,1090,0.924,"INC.280, LY2801653, PHA.665752, PF.04217903",0.347753658996677,0.0343280287798933,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",-0.28214,-0.673,0.875,1068,1,"vinflunine, D.64131, podophyllotoxin, cytochalasin.b, vinblastine",0.0579919469776868,0,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",-0.21918,-0.53,0.973,1012,1,"AZD8055, WYE.354, OSI.027, PF.04691502, voxtalisib, XL388, WAY.600, PP242, GSK2126458",0.0118871597316481,0,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",-0.23599,-0.567,0.941,1114,1,"betulinic.acid, bortezomib, curcumin, BAY.11.7085",0.0264103765727431,0,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.41828,-1.01,0.457,878,0.924,"spiradoline, cebranopadol, ADL5859, trimebutine",0.34008379993015,0.0343280287798933,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",-0.35563,-0.879,0.592,810,0.909,"SB.242235, skepinone.l, TAK.715, CMPD.1, SB.239063",0.22767829327708,0.0414361167780325,FALSE
+"HCC44","Pearson.est","PARP inhibitor",0.39246,1.02,0.415,249,0.839,"AZD2461, PJ.34, AG.14361",0.381951903287907,0.0762380391712997,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.46181,1.18,0.282,302,0.636,"nintedanib, trapidil, pazopanib, motesanib, lenvatinib, axitinib, dovitinib, sorafenib, sunitinib, masitinib, regorafenib, linifanib, telatinib, orantinib",0.549750891680639,0.196542884351586,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",0.49542,1.26,0.193,337,0.666,"GSK2830371, BVT.948, bis.maltolato.oxovanadium.IV., menadione, CID.5458317, sodium.stibogluconate",0.714442690992226,0.176525770829699,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.3008,-0.716,0.799,1069,1,"cilostamide, zardaverine, EMD.53998, papaverine, YM.976",0.0974532206860086,0,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",-0.34926,-0.832,0.664,1022,0.966,"GDC.0941, taselisib, PF.04691502, buparlisib, voxtalisib, CH5132799, AZD6482, GSK2126458, alpelisib, TG.100713",0.177831920631982,0.0150228735845067,FALSE
+"HCC44","Pearson.est","PLK inhibitor",-0.61739,-1.47,0.106,927,0.478,"GSK461364, BI.2536, GW.843682X, rigosertib, NMS.1286937",0.97469413473523,0.320572103387881,FALSE
+"HCC44","Pearson.est","potassium channel blocker",0.37933,0.977,0.458,901,0.813,"dofetilide, mepivacaine, ibutilide, ML133, meglitinide, oleoylethanolamide",0.339134521996131,0.0899094544059319,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",0.61732,1.59,0.0784,131,0.348,"GW.501516, clofibrate, pterostilbene",1.10568393731556,0.458420756053419,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",0.52195,1.37,0.138,140,0.62,"danazol, norethindrone.acetate, norethindrone",0.860120913598763,0.207608310501746,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",0.64055,1.67,0.0554,134,0.346,"delanzomib, oprozomib, MG.132, ONX.0914",1.25649023527157,0.460923901207223,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",-0.15624,-0.371,0.998,1120,1,"cycloheximide, brefeldin.a, thiostrepton, tedizolid.phosphate",0.000869458712628891,0,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.60716,-1.46,0.104,1260,0.443,"PP.121, NVP.TAE226, AV.412, BMS.599626",0.98296666070122,0.35359627377693,FALSE
+"HCC44","Pearson.est","RAF inhibitor",0.46046,1.23,0.228,331,0.583,"sorafenib, regorafenib, TAK.632, RAF265, vemurafenib, PLX.4720, dabrafenib",0.642065152999546,0.234331445240986,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.39285,-0.954,0.512,1406,0.925,"vandetanib",0.290730039024169,0.0338582672609674,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",0.51703,1.32,0.164,289,0.6,"fenretinide, adapalene, LE.135, bexarotene, adarotene",0.785156151952302,0.221848749616356,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.48175,1.24,0.203,61,0.606,"pentostatin, cladribine",0.692503962086787,0.217527375833714,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.54996,-1.34,0.153,944,0.489,"pardoprunox, SR.57227A, aripiprazole, ipsapirone",0.815308569182401,0.31069114087638,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.40432,-0.975,0.493,1164,0.918,"aripiprazole, RS.16566, pirenperone, SB.228357",0.30715308072277,0.0371573187987575,FALSE
+"HCC44","Pearson.est","sodium channel blocker",0.39294,1.01,0.425,66,0.82,"oxcarbazepine, cibenzoline, triamterene",0.371611069949688,0.0861861476162833,FALSE
+"HCC44","Pearson.est","src inhibitor",-0.69916,-1.69,0.0218,1344,0.365,"ZM.306416, bosutinib, saracatinib, dasatinib",1.6615435063954,0.437707135543525,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",0.79065,2.06,0.00477,124,0.0971,"ketoconazole, chlormidazole, lanoconazole, posaconazole",2.32148162095989,1.012780770092,TRUE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",0.26929,0.693,0.829,203,0.947,"SB.525334, adaprev",0.0814454694497265,0.0236500209967266,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.57027,-1.34,0.168,1086,0.489,"trifluridine, ftorafur, capecitabine, raltitrexed, carmofur",0.774690718274137,0.31069114087638,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",-0.38544,-0.94,0.522,1013,0.882,"genz.644282, voreloxin, teniposide, amsacrine, TAS.103, mitoxantrone, rubitecan, licochalcone.a, camptothecin, idarubicin, SN.38, fleroxacin, exatecan.mesylate",0.282329496997738,0.0545314148681803,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.6189,-1.51,0.0775,996,0.447,"oxibendazole, ABT.751, epothilone.d, dolastatin.10, vindesine, plinabulin, BNC105, podophyllotoxin, albendazole, vinblastine, verubulin, fosbretabulin, indibulin, paclitaxel, docetaxel, epothilone.b, parbendazole, nocodazole",1.11069829749369,0.349692476868064,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.55177,-1.33,0.142,1372,0.475,"aminopurvalanol.a, NVP.TAE226, tivantinib, vandetanib, AV.412, BMS.599626, dasatinib",0.847711655616944,0.323306390375133,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",0.2805,0.739,0.774,302,1,"nintedanib, tivozanib, pazopanib, motesanib, lenvatinib, axitinib, dovitinib, sorafenib, sunitinib, regorafenib, linifanib, SAR131675, telatinib, RAF265, orantinib",0.111259039317107,0,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",-0.24834,-0.595,0.945,872,1,"alfacalcidol, tacalcitol, ercalcitriol",0.0245681914907371,0,FALSE
+"A549","Pearson.est","EGFR inhibitor",0.33888,0.978,0.431,150,0.718,"CUDC.101, tucatinib, canertinib, AST.1306, AZD8931, BIBX.1382, lapatinib, neratinib",0.365522729839268,0.1438755557577,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",-0.60157,-1.48,0.0814,1088,0.469,"KW.2449, flumatinib, bosutinib, GZD824, metatinib, ponatinib, nilotinib, dasatinib",1.0893755951108,0.328827157284917,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",0.3301,0.945,0.496,972,0.69,"xanomeline, oxiracetam, nefiracetam, tremorine, nicotine, pilocarpine",0.304518323509803,0.161150909262745,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",-0.30649,-0.751,0.786,1062,0.991,"dicycloverine, methscopolamine",0.104577453960592,0.00392634551472468,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.35878,0.991,0.412,931,0.739,"MRS.1220, CGS.15943, SCH.58261, istradefylline, sulmazole, PSB.1115, theophylline",0.385102783966865,0.131355561605174,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",-0.3005,-0.736,0.805,1238,0.991,"isoetharine, isoxsuprine, buphenine, clenbuterol",0.0942041196321315,0.00392634551472468,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",-0.37354,-0.909,0.582,1092,0.92,"carvedilol, vincamine, dronedarone, imiloxan, levobunolol, atipamezole, pindolol",0.235077015350112,0.0362121726544447,FALSE
+"A549","Pearson.est","AKT inhibitor",0.51381,1.45,0.102,80,0.27,"GDC.0068, uprosertib, GSK2110183, MK.2206",0.991399828238082,0.568636235841013,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33285,-0.831,0.667,1428,0.885,"AZD3463",0.175874166083451,0.0530567293021746,FALSE
+"A549","Pearson.est","androgen receptor antagonist",-0.78373,-1.95,0.00137,1411,0.0473,"nilutamide, RU.58841, cyproterone.acetate",2.86327943284359,1.32513885926219,TRUE
+"A549","Pearson.est","antioxidant",-0.64661,-1.59,0.0298,1004,0.372,"chlorogenic.acid, taurine, trolox, rutin",1.52578373592374,0.429457060118102,FALSE
+"A549","Pearson.est","AP inhibitor",0.40985,1.21,0.236,857,0.494,"embelin, tanshinone.i, birinapant, idronoxil, LCL.161, GDC.0152",0.627087997029893,0.306273051076353,FALSE
+"A549","Pearson.est","ATPase inhibitor",-0.65379,-1.61,0.032,1274,0.389,"blebbistatin...., digoxin, digitoxin, ouabain, digitoxigenin",1.49485002168009,0.410050398674292,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.36789,-0.909,0.589,868,0.92,"alisertib, MK.8745, SNS.314, MK.5108, hesperadin, KW.2449, CYC116, MLN.8054, AT.9283, CCT129202, AMG900, PF.03814735",0.229884705212898,0.0362121726544447,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42893,-1.06,0.402,972,0.803,"tilmicosin, tedizolid, dirithromycin, valnemulin, radezolid",0.39577394691553,0.095284454721319,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.34546,-0.869,0.638,1362,0.882,"finafloxacin",0.195179321278838,0.0545314148681803,FALSE
+"A549","Pearson.est","BCL inhibitor",-0.38822,-0.962,0.507,1072,0.941,"TW.37, navitoclax, gossypol",0.294992040666664,0.0264103765727431,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.62275,-1.54,0.0637,1138,0.376,"flumatinib, bosutinib, GZD824, metatinib, ponatinib, nilotinib, dasatinib",1.19586056766465,0.424812155072339,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",-0.2374,-0.582,0.935,1119,0.966,"lorazepam, CGS.20625, ivermectin, eprinomectin",0.0291883891274822,0.0150228735845067,FALSE
+"A549","Pearson.est","bromodomain inhibitor",0.77989,2.22,0,248,0.0603,"I.BET151, OTX015, JQ1...., I.BET.762, PFI.1",Inf,1.21968268785985,TRUE
+"A549","Pearson.est","calcium channel blocker",0.21198,0.629,0.905,244,0.908,"fendiline, penfluridol",0.0433514207947967,0.0419141514789149,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",-0.36392,-0.889,0.591,1341,0.911,"navarixin",0.228412519118745,0.0404816230270017,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.51895,-1.27,0.192,1283,0.597,"NU6027, kenpaullone, R547, AZD5438, palbociclib, PHA.848125, abemaciclib, BMS.265246",0.71669877129645,0.224025668870631,FALSE
+"A549","Pearson.est","CHK inhibitor",0.5306,1.52,0.086,211,0.274,"PF.477736, LY2606368",1.06550154875643,0.562249437179612,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",-0.23348,-0.588,0.929,908,0.997,"meloxicam, piroxicam, suxibuzone, FR.122047, acetylsalicylsalicylic.acid, tryptanthrin, ketoprofen, indoprofen, tepoxalin",0.0319842860063582,0.00130484168834428,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",-0.50773,-1.24,0.199,978,0.641,"metyrapone, itraconazole, cobicistat, eplerenone",0.701146923590293,0.193141970481183,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.58601,-1.43,0.0994,1087,0.499,"carmustine, TH.302, melphalan, ifosfamide, carboplatin, dianhydrogalactitol, streptozotocin, mitomycin.c",1.00261361560269,0.30189945437661,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.35469,-0.885,0.594,1055,0.896,"nimorazole, carmustine, melphalan, carboplatin, tirapazamine, valrubicin, teroxirone",0.226213555018806,0.0476919903378748,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.56793,1.6,0.0839,61,0.288,"SGI.1027, azacitidine",1.0762380391713,0.540607512240769,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",0.2253,0.65,0.906,230,0.967,"cephalomannine, cidofovir, menadione",0.0428718023231869,0.0145735259169983,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.56393,-1.41,0.109,1247,0.507,"artesunate, azodicarbonamide, floxuridine, cyclocytidine, anisomycin, mitomycin.c",0.962573502059376,0.294992040666664,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",-0.34429,-0.835,0.663,1073,0.899,"amisulpride, nemonapride, piperacetazine, mesoridazine, acetophenazine, remoxipride, UH.232...., raclopride",0.178486471595227,0.0462403082667712,FALSE
+"A549","Pearson.est","estrogen receptor agonist",-0.37469,-0.925,0.545,1091,0.94,"estradiol.cypionate, estradiol, estrone",0.263603497723358,0.0268721464003014,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.65731,1.87,0.0294,273,0.166,"toremifene, clomifene, raloxifene, tamoxifen",1.53165266958784,0.779891911959945,TRUE
+"A549","Pearson.est","FGFR inhibitor",-0.26314,-0.638,0.881,970,1,"lucitanib, nintedanib, AZD4547",0.0550240915879521,0,FALSE
+"A549","Pearson.est","FLT3 inhibitor",-0.47559,-1.15,0.298,1083,0.734,"TG.101348, KW.2449, GTP.14564, ponatinib, midostaurin, quizartinib",0.525783735923745,0.134303940083929,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.53713,-1.33,0.151,1146,0.588,"ciclesonide, flumethasone, flumethasone.pivalate, fludroxycortide, deflazacort, desonide, rimexolone, fluticasone.propionate, triamcinolone, prednisolone.acetate, beclomethasone.dipropionate, halobetasol.propionate, fluocinolone.acetonide",0.821023052706831,0.230622673923862,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.34427,0.942,0.517,95,0.657,"felbamate, CPP, CGP.37849",0.286509456906058,0.182434630440219,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.28529,-0.707,0.797,1300,0.991,"TWS.119, kenpaullone",0.0985416786038876,0.00392634551472468,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",-0.82708,-2.06,0,1415,0.0193,"PHA.848125, AZD3463",Inf,1.71444269099223,TRUE
+"A549","Pearson.est","HCV inhibitor",-0.24908,-0.611,0.905,1103,1,"Ro.9187, mericitabine",0.0433514207947967,0,FALSE
+"A549","Pearson.est","HDAC inhibitor",0.49376,1.45,0.122,281,0.27,"M.344, tacedinaline, PCI.24781, vorinostat, romidepsin, nexturastat.a, JNJ.26481585, R306465, trichostatin.a, panobinostat, NSC.3852",0.913640169325252,0.568636235841013,FALSE
+"A549","Pearson.est","histamine receptor antagonist",-0.17076,-0.424,0.992,965,0.994,"tiotidine, zolantidine, famotidine, terfenadine, pheniramine, BF2.649, nizatidine",0.00348832784582135,0.00261361560268669,FALSE
+"A549","Pearson.est","HMGCR inhibitor",0.21845,0.629,0.911,1133,0.908,"simvastatin, pitavastatin, atorvastatin, lovastatin, mevastatin, fluvastatin",0.0404816230270017,0.0419141514789149,FALSE
+"A549","Pearson.est","HSP inhibitor",-0.2821,-0.693,0.829,929,0.989,"BIIB021, XL888, PU.H71, NVP.AUY922, SNX.2112, ganetespib, tanespimycin",0.0814454694497265,0.0048037084028206,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.45014,-1.11,0.332,1083,0.801,"TG.101348, AT.9283, CEP.33779, WHI.P154, filgotinib, TG.101209, AZ960",0.478861916295964,0.0963674839157623,FALSE
+"A549","Pearson.est","KIT inhibitor",-0.3727,-0.927,0.575,1366,0.963,"dasatinib, midostaurin, KI.8751",0.24033215531037,0.0163737128754655,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.69487,-1.75,0.00811,1002,0.174,"AMG.232, nutlin.3, serdemetan, CGM097, idasanutlin, RITA",2.09097914578884,0.7594507517174,TRUE
+"A549","Pearson.est","MEK inhibitor",0.27388,0.783,0.726,289,0.904,"MEK162, BIX.02188, cobimetinib, AS.703026, MEK1.2.inhibitor, trametinib, PD.98059",0.139063379299906,0.0438315695246367,FALSE
+"A549","Pearson.est","MET inhibitor",-0.52257,-1.29,0.17,1173,0.581,"LY2801653, NVP.BVU972, PF.04217903",0.769551078621726,0.235823867609669,FALSE
+"A549","Pearson.est","microtubule inhibitor",-0.42385,-1.06,0.378,788,0.803,"vinblastine, cabazitaxel, D.64131, secnidazole, podophyllotoxin, estramustine.phosphate, cytochalasin.b",0.422508200162775,0.095284454721319,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.62381,-1.55,0.0622,1060,0.405,"palomid.529, everolimus, voxtalisib, PKI.179, PI.103, PP242, deforolimus, WYE.125132, XL388, AZD2014, temsirolimus, sirolimus, WAY.600, LY3023414, AZD8055, NVP.BEZ235, ku.0063794, GDC.0980, WYE.354, MLN0128, SB.2343, torin.1",1.20620961530918,0.392544976785331,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",0.50287,1.41,0.109,209,0.283,"parthenolide...., bortezomib, Ro.106.9920, curcumin, tyloxapol, parthenolide",0.962573502059376,0.54821356447571,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.53415,-1.31,0.166,931,0.564,"spiradoline, BW.180C, salvinorin.a, trimebutine, cebranopadol",0.779891911959945,0.248720896016658,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",-0.25429,-0.633,0.898,1194,1,"skepinone.l",0.0467236633326956,0,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.44298,-1.1,0.358,1434,0.795,"E7449",0.446116973356126,0.0996328713435297,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.39754,-0.978,0.49,887,0.936,"trapidil, tandutinib, motesanib, vatalanib, linifanib, nintedanib, telatinib, ponatinib, CP.673451, dasatinib, KI.8751, crenolanib",0.309803919971486,0.0287241512618947,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.24031,-0.592,0.92,1207,1,"GSK2830371, mycophenolic.acid",0.0362121726544447,0,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",-0.54342,-1.34,0.124,1174,0.601,"anagrelide, GSK256066, zardaverine, YM.976",0.906578314837765,0.22112552799726,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.36035,-0.882,0.615,1022,0.88,"GSK2126458, TG.100713, GDC.0941, voxtalisib, PKI.179, PI.103, BGT226, ZSTK.474, LY3023414, PI3K.IN.2, NVP.BEZ235, GDC.0980, SB.2343",0.211124884224583,0.0555173278498314,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.57832,-1.43,0.0989,859,0.499,"BI.2536, HMN.214, rigosertib, GSK461364, GW.843682X, volasertib",1.00480370840282,0.30189945437661,FALSE
+"A549","Pearson.est","potassium channel blocker",-0.70541,-1.81,0.00551,1297,0.137,"ML133, ibutilide",2.25884840114822,0.863279432843593,TRUE
+"A549","Pearson.est","PPAR receptor agonist",0.33765,0.963,0.513,259,0.699,"pterostilbene, clofibrate",0.289882634888184,0.155522824254319,FALSE
+"A549","Pearson.est","progesterone receptor agonist",-0.40909,-1.01,0.466,830,0.89,"norethindrone.acetate, norethindrone, norgestrel, dienogest, melengestrol.acetate, tanaproget",0.33161408331,0.0506099933550872,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.59865,1.66,0.037,292,0.282,"carfilzomib, ONX.0914, bortezomib, oprozomib, delanzomib",1.431798275933,0.549750891680639,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.3832,-0.934,0.55,1180,0.976,"emetine, cycloheximide, methacycline, mercaptopurine, florfenicol",0.259637310505756,0.0105501823333082,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.29917,-0.733,0.797,1204,0.975,"BMS.599626, mubritinib",0.0985416786038876,0.0109953843014632,FALSE
+"A549","Pearson.est","RAF inhibitor",0.55808,1.54,0.0913,328,0.298,"AZ.628, vemurafenib, regorafenib, GDC.0879, TAK.632, dabrafenib, LGX818",1.0395292224657,0.525783735923745,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",0.40707,1.15,0.278,861,0.544,"regorafenib, sorafenib, vandetanib, sunitinib, cabozantinib, apatinib",0.555955204081924,0.26440110030182,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.67559,1.97,0.00791,216,0.156,"fenretinide, adapalene, adarotene, tamibarotene, CD.437, AM.580",2.10182351650232,0.806875401645538,TRUE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.46328,-1.15,0.298,1112,0.734,"triapine, cladribine, clofarabine, gemcitabine",0.525783735923745,0.134303940083929,FALSE
+"A549","Pearson.est","serotonin receptor agonist",-0.56292,-1.4,0.118,1336,0.493,"ipsapirone, aripiprazole",0.928117992693875,0.30715308072277,FALSE
+"A549","Pearson.est","serotonin receptor antagonist",0.23767,0.672,0.871,5,0.986,"lurasidone",0.0599818449923368,0.0061230850587888,FALSE
+"A549","Pearson.est","sodium channel blocker",-0.34226,-0.856,0.66,1246,0.884,"ajmaline, A.803467, butamben",0.180456064458131,0.0535477349869269,FALSE
+"A549","Pearson.est","src inhibitor",-0.47127,-1.18,0.28,1152,0.724,"bosutinib, KX2.391, dasatinib",0.552841968657781,0.140261433802853,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",-0.48612,-1.19,0.246,994,0.734,"lanoconazole, ketoconazole",0.609064892896621,0.134303940083929,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",0.38538,1.08,0.309,280,0.623,"LY2109761, D.4476, SB.525334",0.510041520575165,0.20551195334083,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",-0.42848,-1.06,0.394,720,0.803,"trifluridine, carmofur, capecitabine, ftorafur, raltitrexed",0.404503778174426,0.095284454721319,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.53261,-1.32,0.164,1293,0.574,"exatecan.mesylate, valrubicin, amonafide, teniposide, voreloxin, amsacrine, fleroxacin, idarubicin, TAS.103",0.785156151952302,0.241088107602027,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",-0.36098,-0.892,0.606,780,0.929,"plinabulin, vinblastine, docetaxel, albendazole, dolastatin.10, parbendazole, fenbendazole, podophyllotoxin, ABT.751, BNC105, CYT.997, taltobulin, combretastatin.A.4, verubulin, KX2.391, epothilone.d, epothilone.b",0.217527375833714,0.0319842860063582,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",-0.23105,-0.562,0.952,1167,0.962,"GTP.14564, BMS.599626, UNC2250, mubritinib, dasatinib",0.0213630516155257,0.0168249279621871,FALSE
+"A549","Pearson.est","VEGFR inhibitor",-0.237,-0.587,0.94,683,0.98,"TG.100572, PD.173074, SU014813, SAR131675, ENMD.2076, cabozantinib, tivozanib, foretinib, cediranib, motesanib, vatalanib, RAF265, lucitanib, linifanib, nintedanib, telatinib, MGCD.265, KI.8751",0.0268721464003014,0.00877392430750515,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",0.23942,0.68,0.867,1103,1,"maxacalcitol, paricalcitol, calcitriol, doxercalciferol, alfacalcidol, ercalcitriol, tacalcitol",0.0619809025237897,0,FALSE
+"H1703","Pearson.est","EGFR inhibitor",0.84369,2.2,0,44,0.0248,"AZD8931, poziotinib, gefitinib, dacomitinib, XL.647, neratinib, canertinib, lapatinib, osimertinib, afatinib, erlotinib, BMS.690514, CUDC.101, BIBU.1361, pelitinib, tucatinib, AST.1306, PD.153035, vandetanib, ARRY.334543, BMS.599626, PD.168393, icotinib, WZ8040",Inf,1.60554831917378,TRUE
+"H1703","Pearson.est","Abl kinase inhibitor",0.31258,0.83,0.65,157,0.97,"dasatinib, ZM.306416, bosutinib",0.187086643357144,0.0132282657337552,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",-0.23569,-0.573,0.941,875,1,"nefiracetam, xanomeline, oxiracetam",0.0264103765727431,0,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.51067,-1.23,0.231,1070,0.601,"darifenacin, methscopolamine, iododexetimide",0.636388020107856,0.22112552799726,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",0.61096,1.55,0.103,93,0.434,"CGS.15943, MRS.1220, SCH.58261",0.987162775294828,0.362510270487489,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",-0.15985,-0.385,0.992,791,0.998,"A61603, buphenine, metaraminol, lidamidine, clenbuterol, midodrine, xylazine",0.00348832784582135,0.000869458712628891,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",-0.25644,-0.625,0.904,931,1,"idazoxan, vincamine, atipamezole, levobunolol, metoprolol, pindolol, carvedilol",0.0438315695246367,0,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.4773,1.25,0.206,258,0.901,"uprosertib, triciribine, GDC.0068, AZD5363, MK.2206, GSK2110183, CCT128930",0.686132779630847,0.045275209020937,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.24274,0.664,0.882,352,0.993,"GW.788388, SB.505124, brigatinib, NVP.TAE684, alectinib",0.0545314148681803,0.00305075150461883,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",-0.46463,-1.11,0.327,670,0.669,"cyproterone.acetate, enzalutamide, bicalutamide, RU.58841, nilutamide, flutamide",0.485452247339714,0.174573882232177,FALSE
+"H1703","Pearson.est","antioxidant",0.38276,1.02,0.405,60,0.769,"mesna",0.392544976785331,0.114073660198569,FALSE
+"H1703","Pearson.est","AP inhibitor",-0.53653,-1.29,0.181,907,0.59,"LCL.161, birinapant, GDC.0152, idronoxil",0.742321425130815,0.229147988357856,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.59625,-1.47,0.0734,965,0.458,"blebbistatin...., evodiamine, omeprazole, ouabain, k.strophanthidin, thonzonium, digitoxin, digitoxigenin, oligomycin.a, digoxin",1.13430394008393,0.339134521996131,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.58796,-1.41,0.105,1022,0.554,"alisertib, hesperadin, KW.2449, CCT137690, tozasertib, MK.5108, MK.8745, barasertib.HQPA, aurora.a.inhibitor.i, danusertib, ZM.447439, AT.9283, SNS.314, AMG900, barasertib, PF.03814735",0.978810700930062,0.25649023527157,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34253,-0.843,0.652,914,0.941,"radezolid, dirithromycin, valnemulin, josamycin",0.18575240426808,0.0264103765727431,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.26605,-0.647,0.888,1092,1,"sparfloxacin, lomefloxacin, norfloxacin",0.051587034221399,0,FALSE
+"H1703","Pearson.est","BCL inhibitor",-0.31789,-0.765,0.732,630,1,"gossypol, ABT.737, venetoclax, navitoclax, HA14.1, oridonin, TW.37",0.135488918941608,0,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.24403,0.63,0.873,157,0.958,"dasatinib, bosutinib",0.0589857562944303,0.0186344909214556,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.25366,0.667,0.862,1084,1,"piperazine, CL.218872, zaleplon, gamma.aminobutyric.acid, lorazepam, ivermectin, eprinomectin, ZK.93423, bentazepam, temazepam, nefiracetam, CGS.20625, indiplon",0.0644927341752872,0,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",0.31137,0.804,0.641,999,0.929,"JQ1...., OTX015, I.BET.762, I.BET151, PFI.1, bromosporine",0.193141970481183,0.0319842860063582,FALSE
+"H1703","Pearson.est","calcium channel blocker",-0.48858,-1.2,0.231,1073,0.581,"penfluridol, pranidipine, SR.33805, carboxyamidotriazole",0.636388020107856,0.235823867609669,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.43989,-1.08,0.369,986,0.706,"SB.225002, PF.04136309, MK.0812, UNBS.5162",0.43297363384094,0.151195298948196,FALSE
+"H1703","Pearson.est","CDK inhibitor",-0.20165,-0.491,0.987,1180,1,"BMS.265246, R547, abemaciclib, PHA.793887",0.00568284733036327,0,FALSE
+"H1703","Pearson.est","CHK inhibitor",-0.27209,-0.667,0.866,1030,1,"SB.218078, PF.477736",0.0624821079826534,0,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",-0.37698,-0.911,0.578,1367,0.892,"suxibuzone, naproxen, tepoxalin, AM.404",0.238072161579471,0.0496351456238769,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",-0.48054,-1.16,0.284,1150,0.612,"metyrapone, clotrimazole, cobicistat",0.546681659952962,0.213248577854439,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.57471,-1.39,0.126,1110,0.555,"mitomycin.c, TH.302, carboplatin, dianhydrogalactitol, satraplatin, cisplatin, melphalan",0.899629454882437,0.255707016877324,FALSE
+"H1703","Pearson.est","DNA inhibitor",-0.52905,-1.32,0.152,1050,0.555,"pibenzimol, teroxirone, tirapazamine, carboplatin, valrubicin, melphalan, chlorambucil",0.818156412055227,0.255707016877324,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",0.44829,1.19,0.239,196,0.754,"azacitidine, fdcyd, decitabine",0.621602099051862,0.122628654130226,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",-0.25521,-0.619,0.917,889,1,"idoxuridine, foscarnet, menadione, cephalomannine",0.0376306643299789,0,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.54212,-1.32,0.17,1015,0.555,"anisomycin, nelarabine, estramustine.phosphate, mitomycin.c, CB.10.277, enocitabine, cisplatin, azodicarbonamide, artemisinin",0.769551078621726,0.255707016877324,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.28806,0.749,0.787,86,0.944,"domperidone, clebopride, lurasidone",0.104025267640935,0.025028005701931,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",0.35275,0.937,0.502,154,0.843,"erteberel, levonorgestrel, ethinyl.estradiol",0.299296282854981,0.0741724253752577,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",0.38931,1.03,0.401,103,0.799,"clomifene, raloxifene",0.396855627379818,0.0974532206860086,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.63655,-1.53,0.0448,1168,0.579,"lenvatinib, MK.2461, regorafenib, dovitinib, nintedanib, erdafitinib",1.34872198600186,0.237321436272564,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",-0.41195,-0.998,0.473,1057,0.769,"KW.2449, tozasertib, dovitinib, sorafenib, TG.101348, quizartinib, midostaurin",0.325138859262188,0.114073660198569,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",0.46794,1.19,0.268,334,0.754,"hydrocortisone, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, flumethasone.pivalate, desonide, fludroxycortide, methylprednisolone, difluprednate, dexamethasone.acetate, betamethasone, prednisolone",0.571865205971211,0.122628654130226,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.40901,1.07,0.336,213,0.768,"diazooxonorleucine, SIB.1757, CGP.37849, kynurenic.acid, IEM1754, latrepirdine",0.473660722610156,0.114638779968488,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.30028,0.793,0.699,123,0.908,"indirubin, LY2090314",0.155522824254319,0.0419141514789149,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",0.24111,0.646,0.882,90,0.977,"GSK1904529A",0.0545314148681803,0.0101054362812269,FALSE
+"H1703","Pearson.est","HCV inhibitor",-0.5096,-1.24,0.214,1041,0.609,"Ro.9187, mericitabine, narlaprevir",0.669586226650809,0.215382707367125,FALSE
+"H1703","Pearson.est","HDAC inhibitor",0.19747,0.519,0.963,1167,1,"JNJ.26481585, panobinostat, romidepsin, PCI.24781, tacedinaline, vorinostat, M.344, givinostat, R306465, mocetinostat, trichostatin.a, ACY.1215, nexturastat.a, AR.42, RGFP966, dacinostat, NSC.3852, pyroxamide, SB.939, belinostat, resminostat, RG2833, entinostat, scriptaid, chidamide",0.0163737128754655,0,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",-0.2244,-0.546,0.97,1231,1,"tiotidine, cimetidine, ICI.162846, nizatidine",0.0132282657337552,0,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.95639,-2.34,0,1419,0,"mevastatin, fluvastatin, atorvastatin, pitavastatin",Inf,Inf,TRUE
+"H1703","Pearson.est","HSP inhibitor",-0.55061,-1.34,0.141,1172,0.589,"PU.H71, SNX.2112, NVP.AUY922, ganetespib, NMS.E973",0.85078088734462,0.229884705212898,FALSE
+"H1703","Pearson.est","JAK inhibitor",-0.22983,-0.554,0.95,1284,1,"PRT062070, TG.101348, AT.9283",0.0222763947111523,0,FALSE
+"H1703","Pearson.est","KIT inhibitor",-0.49022,-1.21,0.251,1168,0.586,"lenvatinib, telatinib, regorafenib, motesanib, cediranib, sorafenib, midostaurin, pazopanib",0.600326278518962,0.232102383981909,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.46747,-1.13,0.322,873,0.649,"CGM097, AMG.232, serdemetan",0.492144128304169,0.187755303199631,FALSE
+"H1703","Pearson.est","MEK inhibitor",0.82206,2.15,0,106,0.0292,"trametinib, AS.703026, cobimetinib, AZD8330, selumetinib, PD.0325901, TAK.733, Ro.4987655, MEK162, PD.318088, refametinib, PD.198306, PD.184352",Inf,1.53461714855158,TRUE
+"H1703","Pearson.est","MET inhibitor",-0.33129,-0.803,0.702,776,0.986,"PF.04217903, PHA.665752, AMG458, LY2801653",0.153662887870195,0.0061230850587888,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.62854,-1.53,0.0586,936,0.579,"triclabendazole, cytochalasin.b, D.64131, estramustine.phosphate, podophyllotoxin, cabazitaxel, secnidazole, vinflunine, vinblastine",1.23210238398191,0.237321436272564,FALSE
+"H1703","Pearson.est","mTOR inhibitor",0.18141,0.487,0.984,293,0.984,"GSK2126458, LY303511, PP242, GDC.0980, WAY.600, PF.04691502, OSI.027, XL388",0.00700490156865849,0.00700490156865849,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.16966,-0.404,0.994,1304,1,"BAY.11.7082",0.00261361560268669,0,FALSE
+"H1703","Pearson.est","opioid receptor agonist",-0.35173,-0.861,0.639,745,0.934,"BW.180C, cebranopadol, salvinorin.a, spiradoline",0.1944991418416,0.0296531237699066,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.4594,1.23,0.222,786,0.838,"SB.239063, SB.242235, talmapimod, skepinone.l, TAK.715, CMPD.1, VX.702",0.653647025549361,0.0767559813697235,FALSE
+"H1703","Pearson.est","PARP inhibitor",-0.55247,-1.34,0.143,1273,0.589,"olaparib, AZD2461, talazoparib",0.844663962534938,0.229884705212898,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49928,-1.21,0.239,1168,0.586,"lenvatinib, telatinib, crenolanib, regorafenib, motesanib, dovitinib, trapidil, sorafenib, axitinib, CP.673451, nintedanib, pazopanib",0.621602099051862,0.232102383981909,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.41229,-1.01,0.461,1019,0.77,"menadione, AS.1949490, BVT.948, bis.maltolato.oxovanadium.IV., GSK2830371",0.336299074610352,0.113509274827518,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",-0.38346,-0.952,0.514,1217,0.835,"YM.976, zardaverine, GSK256066",0.289036881004724,0.0783135245163979,FALSE
+"H1703","Pearson.est","PI3K inhibitor",0.41176,1.12,0.316,288,0.777,"alpelisib, taselisib, GSK2126458, CH5132799, TG.100713, LY303511, PI.828, GDC.0980, TG100.115, GDC.0941, PF.04691502, PIK.75",0.500312917381596,0.109578981199086,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.66503,-1.65,0.0201,1195,0.445,"GSK461364, HMN.214, BI.2536, rigosertib, volasertib",1.69680394257951,0.351639989019068,FALSE
+"H1703","Pearson.est","potassium channel blocker",-0.52198,-1.25,0.221,1424,0.618,"dofetilide",0.655607726314889,0.209011524911184,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",-0.42413,-1.03,0.409,935,0.783,"pterostilbene, clofibrate, GW.501516",0.388276691992658,0.106238237942057,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.35313,-0.864,0.644,953,0.955,"danazol, norgestrel, norethindrone, dienogest, tanaproget",0.191114132640188,0.0199966284162537,FALSE
+"H1703","Pearson.est","proteasome inhibitor",-0.40969,-1.01,0.451,837,0.77,"oprozomib, ixazomib, ONX.0914, delanzomib, MG.132",0.345823458122039,0.113509274827518,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.49598,-1.19,0.259,1124,0.577,"clofoctol, thiostrepton, bruceantin, puromycin, homoharringtonine, mercaptopurine, harringtonine, anguidine",0.586700235918748,0.238824186844269,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.56713,1.53,0.074,153,0.393,"BMS.599626, AV.412, NVP.TAE226, CP.724714",1.13076828026902,0.405607449624573,FALSE
+"H1703","Pearson.est","RAF inhibitor",-0.29377,-0.696,0.839,1200,1,"regorafenib, PLX.4720, RAF265, sorafenib",0.0762380391712997,0,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.36254,0.932,0.522,32,0.808,"vandetanib",0.282329496997738,0.0925886392254138,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",0.42019,1.11,0.329,43,0.739,"CD.437, tamibarotene",0.482804102050026,0.131355561605174,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.61434,-1.48,0.058,1278,0.65,"gemcitabine, fludarabine, cladribine, pentostatin, clofarabine",1.23657200643706,0.187086643357144,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",-0.61085,-1.47,0.0695,1100,0.458,"SR.57227A, pardoprunox, aripiprazole",1.15801519540989,0.339134521996131,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",-0.53052,-1.28,0.173,1259,0.58,"paliperidone, lerisetron, aripiprazole",0.761953896871205,0.236572006437063,FALSE
+"H1703","Pearson.est","sodium channel blocker",-0.2486,-0.608,0.914,1294,1,"butamben, cibenzoline",0.0390538042661686,0,FALSE
+"H1703","Pearson.est","src inhibitor",0.61949,1.65,0.0552,157,0.356,"saracatinib, dasatinib, ZM.306416, bosutinib",1.2580609222708,0.448550002027125,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.28998,-0.698,0.829,1133,1,"posaconazole, chlormidazole",0.0814454694497265,0,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.41788,1.12,0.321,346,0.777,"repsox, LY2109761, D.4476, SB.431542",0.493494967595128,0.109578981199086,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",0.30513,0.804,0.703,1008,0.929,"carmofur, capecitabine, raltitrexed, ftorafur, trifluridine, doxifluridine",0.153044674980176,0.0319842860063582,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.75302,-1.82,0.00611,1232,0.167,"dexrazoxane, amsacrine, idarubicin, rubitecan, doxorubicin, voreloxin, valrubicin, nemorubicin, mitoxantrone, amonafide, TAS.103, daunorubicin, topotecan, etoposide, etoposide.phosphate, teniposide, epirubicin",2.21395878975745,0.777283528852417,TRUE
+"H1703","Pearson.est","tubulin polymerization inhibitor",-0.60635,-1.47,0.0696,1090,0.458,"plinabulin, epothilone.b, vinorelbine, podophyllotoxin, ABT.751, docetaxel, epothilone.d, dolastatin.10, paclitaxel, CYT.997, vindesine, vincristine, KX2.391, combretastatin.A.4, vinblastine, taltobulin, verubulin, BNC105",1.15739076038944,0.339134521996131,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.37091,0.969,0.453,153,0.825,"vandetanib, BMS.599626, dasatinib, AV.412, NVP.TAE226, hypericin, CP.724714",0.343901797987168,0.0835460514500749,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",-0.29519,-0.718,0.799,1168,1,"lenvatinib, telatinib, MK.2461, regorafenib, motesanib, dovitinib, cediranib, SAR131675, RAF265, sorafenib, axitinib, tivozanib, nintedanib, pazopanib",0.0974532206860086,0,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.64785,1.69,0.0452,362,0.394,"tacalcitol, maxacalcitol, calcitriol, paricalcitol, ercalcitriol, alfacalcidol",1.34486156518862,0.404503778174426,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",0.70426,1.79,0.0128,140,0.252,"gefitinib, CUDC.101, poziotinib, XL.647, AZD8931, afatinib, pelitinib, erlotinib, lapatinib, dacomitinib, osimertinib, neratinib, BIBU.1361, canertinib, icotinib, tucatinib, vandetanib, PD.153035, AST.1306, WZ.4002, WZ.3146",1.89279003035213,0.598599459218456,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",0.54588,1.36,0.145,355,0.449,"tozasertib, ZM.306416, dasatinib, GZD824, bafetinib, ponatinib, nilotinib",0.838631997765025,0.347753658996677,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",-0.36518,-0.945,0.496,1362,0.771,"nefiracetam",0.304518323509803,0.112945621949043,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.28903,-0.761,0.745,1098,0.942,"darifenacin, dicycloverine, methscopolamine",0.127843727251707,0.0259490972071227,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",0.42122,1.07,0.365,518,0.677,"sulmazole, istradefylline, CGS.15943, PSB.1115, MRS.1220, SCH.58261",0.437707135543525,0.169411331314856,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",-0.28056,-0.735,0.762,1129,0.952,"norepinephrine, lidamidine, isoetharine, midodrine, xylazine, clenbuterol",0.1180450286604,0.0213630516155257,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",-0.41922,-1.07,0.349,1180,0.703,"prazosin, atenolol...., vincamine, levobunolol, metoprolol, propranolol, pindolol",0.45717457304082,0.153044674980176,FALSE
+"HCC15","Pearson.est","AKT inhibitor",0.45043,1.13,0.312,116,0.621,"uprosertib, MK.2206, GSK2110183",0.505845405981557,0.20690839982342,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.42216,1.06,0.391,457,0.67,"CEP.37440, lorlatinib, SB.505124, alectinib, crizotinib, GW.788388",0.407823242604133,0.173925197299174,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.79972,-2.09,0.0023,1386,0.0654,"enzalutamide, RU.58841, cyproterone.acetate",2.63827216398241,1.18442225167573,TRUE
+"HCC15","Pearson.est","antioxidant",-0.61264,-1.57,0.0685,1436,0.403,"taurine, rutin",1.16430942850757,0.39469495385889,FALSE
+"HCC15","Pearson.est","AP inhibitor",-0.47323,-1.21,0.227,1286,0.747,"birinapant, LCL.161, GDC.0152",0.643974142806877,0.126679398184601,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",-0.37987,-1.01,0.438,1225,0.715,"digitoxin, rabeprazole, oligomycin.a, digitoxigenin",0.3585258894959,0.145693958198919,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",-0.23658,-0.612,0.913,980,0.909,"hesperadin, AT.9283, aurora.a.inhibitor.i, KW.2449, MK.5108, MLN.8054, CYC116, MK.8745, ZM.447439, PF.03814735",0.039529222465701,0.0414361167780325,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.46994,-1.2,0.249,857,0.66,"tilmicosin, azalomycin.b, tedizolid, dirithromycin, josamycin, radezolid",0.603800652904264,0.180456064458131,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",-0.36423,-0.942,0.491,1245,0.745,"trovafloxacin, nadifloxacin",0.308918507877032,0.127843727251707,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.42031,1.05,0.415,410,0.64,"obatoclax, ABT.737, venetoclax, gossypol",0.381951903287907,0.193820026016113,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.55859,1.41,0.126,355,0.428,"tozasertib, dasatinib, GZD824, bafetinib, ponatinib, nilotinib",0.899629454882437,0.368556230986828,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.33971,0.874,0.603,207,0.787,"bentazepam, ZK.93423, piperazine, CL.218872",0.219682687859849,0.104025267640935,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.5447,1.36,0.147,389,0.449,"I.BET.762, JQ1...., I.BET151, OTX015",0.832682665251824,0.347753658996677,FALSE
+"HCC15","Pearson.est","calcium channel blocker",0.30435,0.768,0.747,357,0.845,"penfluridol, SKF.96365, efonidipine.monoethanolate",0.126679398184601,0.0731432910503077,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.57888,1.46,0.106,177,0.412,"ZK811752, PF.04136309",0.97469413473523,0.385102783966865,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.36157,0.908,0.564,198,0.775,"indisulam, P276.00, alvocidib, dinaciclib, AT.7519, TG.02",0.248720896016658,0.11069829749369,FALSE
+"HCC15","Pearson.est","CHK inhibitor",0.62723,1.57,0.0645,411,0.537,"PF.477736, LY2606368, LY2603618, AZD7762",1.19044028536473,0.270025714300444,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.38956,-1.02,0.425,1019,0.729,"amfenac, acetylsalicylsalicylic.acid, pterostilbene, tryptanthrin, indoprofen, AM.404, sulfasalazine, metoxibutropate, suxibuzone, naproxen",0.371611069949688,0.137272471682025,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",0.38543,0.971,0.477,215,0.688,"metyrapone, morin",0.321481620959886,0.162411561764489,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",-0.45028,-1.15,0.278,1218,0.627,"satraplatin, melphalan, cisplatin, streptozotocin, dianhydrogalactitol, mitomycin.c",0.555955204081924,0.202732459169284,FALSE
+"HCC15","Pearson.est","DNA inhibitor",-0.26157,-0.69,0.809,1223,0.876,"melphalan, nimorazole, primaquine, tirapazamine",0.0920514783877277,0.0574958938319193,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.33138,0.844,0.631,372,0.791,"azacitidine, decitabine, disulfiram",0.199970640755866,0.101823516502323,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.3126,0.79,0.704,57,0.834,"cidofovir",0.152427340857888,0.0788339493622613,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",-0.62832,-1.62,0.0364,1322,0.634,"cisplatin, artemisinin, floxuridine, estramustine.phosphate, mitomycin.c",1.43889861635094,0.197910742118267,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",0.29617,0.746,0.761,268,0.835,"clebopride, lurasidone, thioproperazine, domperidone, sertindole",0.118615343229427,0.0783135245163979,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.27324,-0.715,0.789,1425,0.924,"estradiol.cypionate",0.10292299679058,0.0343280287798933,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",0.53082,1.35,0.163,361,0.438,"raloxifene, clomifene, toremifene, tamoxifen",0.787812395596042,0.3585258894959,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.5292,1.34,0.187,214,0.428,"regorafenib, PD.173074, MK.2461, lucitanib",0.728158393463501,0.368556230986828,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.4777,1.23,0.215,319,0.504,"tozasertib, gilteritinib, pacritinib, tyrphostin.AG.1296, sorafenib, TG.02, sunitinib, ponatinib, lestaurtinib, ENMD.2076",0.667561540084395,0.297569463554475,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",0.39731,1.01,0.449,71,0.686,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate",0.347753658996677,0.163675884293248,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",-0.25626,-0.666,0.837,1319,0.88,"latrepirdine, ACDPP",0.07727454200674,0.0555173278498314,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.2738,-0.714,0.793,1169,0.897,"CHIR.98014, kenpaullone, indirubin",0.100726812682396,0.0472075569559079,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",0.26463,0.672,0.849,541,0.909,"lestaurtinib, GSK1838705A, PHA.848125, GSK1904529A, danusertib",0.0710923097560473,0.0414361167780325,FALSE
+"HCC15","Pearson.est","HCV inhibitor",0.30263,0.759,0.74,72,0.837,"embelin",0.130768280269024,0.07727454200674,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.61057,1.52,0.0518,178,0.429,"M.344, PCI.24781, R306465, vorinostat, romidepsin, dacinostat, NSC.3852, givinostat, trichostatin.a, tacedinaline, belinostat, panobinostat, JNJ.26481585, nexturastat.a",1.28567024025477,0.367542707815276,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",0.22815,0.585,0.911,397,0.951,"ranitidine, chloropyramine, pheniramine, ebastine, astemizole, tecastemizole, lafutidine",0.0404816230270017,0.0218194830625861,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",0.60472,1.55,0.0599,576,0.424,"pitavastatin, lovastatin, mevastatin, simvastatin, fluvastatin, atorvastatin",1.22257317761069,0.372634143407267,FALSE
+"HCC15","Pearson.est","HSP inhibitor",-0.53441,-1.39,0.134,1202,0.503,"KW.2478, XL888, alvespimycin, PU.H71, VER.49009, tanespimycin",0.872895201635192,0.298432014944073,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.33521,0.862,0.614,198,0.785,"atiprimod, tozasertib, pacritinib, TG.02",0.211831628858832,0.105130343254747,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.35174,0.875,0.606,273,0.809,"regorafenib, dasatinib, sorafenib, sunitinib, pazopanib",0.217527375833714,0.0920514783877277,FALSE
+"HCC15","Pearson.est","MDM inhibitor",0.38981,1,0.43,159,0.681,"idasanutlin, nutlin.3",0.366531544420413,0.166852888087215,FALSE
+"HCC15","Pearson.est","MEK inhibitor",0.59336,1.49,0.0823,239,0.396,"MEK162, cobimetinib, AZD8330, TAK.733, AS.703026, MEK1.2.inhibitor, trametinib, PD.0325901, Ro.4987655, BIX.02188",1.08460016478773,0.402304814074488,FALSE
+"HCC15","Pearson.est","MET inhibitor",-0.58926,-1.52,0.0831,1261,0.375,"PF.04217903, NVP.BVU972",1.08039897621589,0.425968732272281,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",-0.44819,-1.16,0.29,1253,0.691,"D.64131, cytochalasin.b, estramustine.phosphate",0.537602002101044,0.160521952625802,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",-0.27999,-0.716,0.762,1184,0.952,"voxtalisib, deforolimus, sirolimus, everolimus, palomid.529, temsirolimus, GDC.0980, SB.2343",0.1180450286604,0.0213630516155257,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.71644,1.82,0.0124,190,0.3,"curcumin, parthenolide...., Ro.106.9920, bortezomib, parthenolide",1.90657831483776,0.522878745280338,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",-0.6001,-1.56,0.0615,976,0.361,"salvinorin.a, trimebutine, cebranopadol, BW.180C, spiradoline",1.21112488422458,0.442492798094342,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",0.50735,1.28,0.193,602,0.474,"SB.242235, talmapimod, SB.239063, CMPD.1, TAK.715",0.714442690992226,0.324221658325915,FALSE
+"HCC15","Pearson.est","PARP inhibitor",-0.38577,-1.02,0.405,1074,0.729,"olaparib, AZD2461, E7449",0.392544976785331,0.137272471682025,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.22807,0.569,0.933,404,0.942,"regorafenib, dasatinib, sorafenib, sunitinib, pazopanib, ponatinib, axitinib, dovitinib, SU014813",0.0301183562535,0.0259490972071227,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.59487,1.5,0.0802,322,0.418,"GSK2830371, CID.5458317, bis.maltolato.oxovanadium.IV., alexidine, sodium.stibogluconate",1.09582563171584,0.378823718224965,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.41628,-1.08,0.34,1096,0.72,"cilostamide, enoximone, zardaverine, papaverine, GSK256066, YM.976",0.468521082957745,0.142667503568732,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",0.25768,0.659,0.843,445,0.902,"buparlisib, YM.201636, LY303511, GSK2126458, CUDC.907, taselisib, TG.100713, pilaralisib, TG100.115, PF.05212384, GDC.0941, AZD6482",0.0741724253752577,0.0447934624580583,FALSE
+"HCC15","Pearson.est","PLK inhibitor",-0.60323,-1.59,0.0584,1148,0.549,"volasertib, GSK461364, HMN.214, BI.2536, GW.843682X",1.2335871528876,0.260427655549908,FALSE
+"HCC15","Pearson.est","potassium channel blocker",-0.60538,-1.58,0.0605,919,0.461,"oleoylethanolamide, ibutilide, meglitinide, dofetilide, ML133",1.21824462534753,0.336299074610352,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.50694,-1.32,0.166,919,0.58,"oleoylethanolamide, S26948, clofibrate, pterostilbene, ciprofibrate, GW.501516",0.779891911959945,0.236572006437063,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.43211,-1.15,0.271,1380,0.627,"norgestrel, dienogest",0.567030709125594,0.202732459169284,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.48506,1.22,0.238,115,0.496,"carfilzomib, bortezomib",0.623423042943488,0.304518323509803,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.43125,1.09,0.325,331,0.667,"clindamycin.phosphate, brefeldin.a, tedizolid.phosphate, azomycin..2.nitroimidazole., homoharringtonine, chloramphenicol.palmitate, bruceantin",0.488116639021126,0.175874166083451,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.40273,0.998,0.445,398,0.662,"AV.412, PP.121, NVP.TAE226",0.351639989019068,0.1791420105603,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.76297,1.93,0.00559,275,0.228,"AZ.628, dabrafenib, vemurafenib, regorafenib, CEP.32496, sorafenib, LGX818, SB.590885, TAK.632",2.25258819211358,0.642065152999546,TRUE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.57292,1.42,0.111,265,0.442,"vandetanib, regorafenib, sorafenib, sunitinib",0.954677021213343,0.354577730650908,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",0.70912,1.78,0.0156,248,0.202,"tamibarotene, CD.437, adarotene, AM.580, fenretinide",1.80687540164554,0.694648630553376,TRUE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.37586,-0.962,0.476,1172,0.772,"hydroxyurea, clofarabine, gemcitabine",0.322393047279507,0.112382699664264,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",-0.68449,-1.75,0.0262,1447,0.46,"aripiprazole",1.58169870868025,0.337242168318426,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",-0.36261,-0.923,0.547,1447,0.749,"aripiprazole",0.262012673666569,0.125518182300534,FALSE
+"HCC15","Pearson.est","sodium channel blocker",-0.33154,-0.882,0.563,1301,0.794,"butamben, lappaconite, oxcarbazepine",0.249491605148654,0.100179497572904,FALSE
+"HCC15","Pearson.est","src inhibitor",0.49409,1.24,0.216,240,0.512,"saracatinib, ZM.306416, dasatinib, PP.2",0.665546248849069,0.290730039024169,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",0.32958,0.829,0.674,646,0.792,"terconazole, sulconazole, lanoconazole, posaconazole, ketoconazole",0.17134010346468,0.101274818410506,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.61759,1.55,0.0537,420,0.424,"repsox, D.4476, LY2109761, SB.525334, SB.431542",1.27002571430044,0.372634143407267,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",-0.27094,-0.703,0.806,1161,0.885,"doxifluridine, raltitrexed",0.0936649581949093,0.0530567293021746,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",-0.5804,-1.5,0.0709,1133,0.361,"valrubicin, rubitecan, etoposide, teniposide, camptothecin, genz.644282, amsacrine, exatecan.mesylate, amonafide, voreloxin, mitoxantrone, TAS.103, idarubicin",1.14935376481693,0.442492798094342,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",-0.31622,-0.81,0.701,1265,0.891,"fenbendazole, CYT.997, ABT.751, epothilone.b, epothilone.d, KX2.391",0.154281982033341,0.0501222959631252,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.50387,1.31,0.164,265,0.452,"tivantinib, vandetanib, regorafenib, dasatinib, AV.412, sorafenib, bafetinib, PP.121, sunitinib",0.785156151952302,0.344861565188618,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.41892,1.05,0.394,319,0.64,"XL.647, vandetanib, ZM.306416, regorafenib, PD.173074, sorafenib, MK.2461, lucitanib, BMS.690514, sunitinib, pazopanib, axitinib, ENMD.2076",0.404503778174426,0.193820026016113,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",-0.45801,-1.2,0.257,962,0.66,"paricalcitol, maxacalcitol, tacalcitol, ercalcitriol, doxercalciferol",0.590066876668705,0.180456064458131,FALSE
diff --git a/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_venn_diagram.pdf b/Examples/cell_corr/Fig4 - Coldren/DMEA/DMEA_venn_diagram.pdf
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--- /dev/null
+++ b/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_interactive_network.graph.html	
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-b0594fe434d057f43f57" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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diff --git a/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_mean_results.csv
new file mode 100644
index 0000000..ba0e91f
--- /dev/null
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+"KEGG_HOMOLOGOUS_RECOMBINATION",1.18275,1.01842115997799,1.62474463133865e-07,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1299, HCC44, H1703",7.55506253572471e-06
+"KEGG_DNA_REPLICATION",1.04791666666667,1.53399872338061,5.18696097500436e-08,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,6,"H2126, H460, H1299, HCC44, H1703, HCC15",3.21591580450271e-06
+"KEGG_MISMATCH_REPAIR",1.03566666666667,1.44466663869894,4.40852347906153e-08,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H460, HCC44, A549, H1703",3.21591580450271e-06
+"KEGG_PHENYLALANINE_METABOLISM",1.03283333333333,1.09196876689711,4.39011978278975e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.000680468566332411
+"KEGG_BASE_EXCISION_REPAIR",0.984083333333333,0.910691890650713,0.00385519218170664,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.02353817641561
+"KEGG_PYRIMIDINE_METABOLISM",0.960333333333333,0.735403455542767,0.0575556683431852,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.175497611669384
+"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.95575,0.241440798314844,0.705125447449297,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.922999363061497
+"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.951166666666667,0.651452340171675,0.159811080572889,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.377825235366307
+"KEGG_PROTEASOME",0.9135,1.10131850731088,0.00137332360738408,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.0106981626914189
+"KEGG_O_GLYCAN_BIOSYNTHESIS",0.860833333333333,1.09987154897398,0.000441836979103135,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.00391341324348491
+"KEGG_SELENOAMINO_ACID_METABOLISM",0.822416666666667,0.961451219235639,0.0275998402701993,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0950661164862421
+"KEGG_RNA_POLYMERASE",0.7885,1.13492582857367,0.00512348170900914,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0277285086897416
+"KEGG_ONE_CARBON_POOL_BY_FOLATE",0.771416666666667,1.26351792147115,6.28560007409116e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.000835086866986397
+"KEGG_PURINE_METABOLISM",0.7655,0.773114304144431,0.417144666625491,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.686627504357003
+"KEGG_ETHER_LIPID_METABOLISM",0.747333333333333,0.853898688192557,0.17373314610447,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.394077624090627
+"KEGG_HISTIDINE_METABOLISM",0.741833333333333,1.13190256835225,0.00206560546850457,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.014777023736225
+"KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.7295,0.918118382147076,0.148050939649012,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.362335194404161
+"KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.724666666666667,0.86145493559478,0.193542911654831,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.413781397331018
+"KEGG_OOCYTE_MEIOSIS",0.712,1.00645263628792,0.0197732493725514,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.072114203594011
+"KEGG_CALCIUM_SIGNALING_PATHWAY",0.706666666666667,0.425593346951873,0.998346846426198,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_ASTHMA",0.704916666666667,1.10983868265399,0.0118763758905152,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0471613911971242
+"KEGG_TYPE_I_DIABETES_MELLITUS",0.6985,0.843247887634472,0.593095271824138,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.875521591740394
+"KEGG_TASTE_TRANSDUCTION",0.69725,0.882656128347326,0.198553570390263,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414954652725718
+"KEGG_VIRAL_MYOCARDITIS",0.680833333333333,0.506877577712685,0.982410393274909,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_TYROSINE_METABOLISM",0.6645,0.93556531281651,0.162505477576906,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.377825235366307
+"KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.658333333333333,1.31386199173784,0.000148532918380909,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.00153484015660272
+"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.658166666666667,1.05997271262762,0.0323073288579678,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.107306485135393
+"KEGG_ALLOGRAFT_REJECTION",0.6395,1.11048437425051,0.206200320144664,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, A549",0.424597927062589
+"KEGG_SPLICEOSOME",0.626333333333333,1.18741180214734,0.00366824597966207,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, H1703",0.0235273707661084
+"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.623,1.42288254162904,0.000129204824688151,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1648, H460",0.00145713690081867
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.62125,0.920005447118262,0.181702152579352,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.394335477996203
+"KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.6165,1.23118040181696,0.000744626347212879,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.00629547729916344
+"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.603583333333333,1.14805736777261,0.176127393056238,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.394335477996203
+"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.597583333333333,1.14971359740616,0.00555856187450555,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0277285086897416
+"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.596916666666667,1.17332917634422,0.00548852272377495,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.0277285086897416
+"KEGG_RNA_DEGRADATION",0.592,1.17083839425198,0.00542506995369291,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0277285086897416
+"KEGG_BETA_ALANINE_METABOLISM",0.58475,1.14564417171381,0.0113183135866127,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0467823628246658
+"KEGG_LINOLEIC_ACID_METABOLISM",0.584083333333333,1.1729841863875,0.0055194143572287,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.0277285086897416
+"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.583916666666667,0.870315873517753,0.584069890300629,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.869095996767337
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.583666666666667,1.66131204081885,1.32004223058374e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1648, H460, H1299, HCC44",0.000313770381199524
+"KEGG_AUTOIMMUNE_THYROID_DISEASE",0.581,1.09163130639008,0.0384793998439777,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.123399454672066
+"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.577166666666667,1.0303212944014,0.0842770264726543,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.244930108186151
+"KEGG_GLUTATHIONE_METABOLISM",0.56975,1.25965212549844,0.00392302940260166,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.02353817641561
+"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.566666666666667,0.611396662395109,0.992143276843358,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_CELL_CYCLE",0.560416666666667,1.19718939477833,0.00617626737248941,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0292555330442391
+"KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.5525,1.38885908048821,2.69543597839784e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.000455773719983634
+"KEGG_MAPK_SIGNALING_PATHWAY",0.5465,0.69266737393145,0.990857642751396,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_GLYCEROLIPID_METABOLISM",0.545583333333333,0.901938463768035,0.506832248307051,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.785589984875929
+"KEGG_ABC_TRANSPORTERS",0.535083333333333,0.946116412050608,0.373795087889975,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.643758206921623
+"KEGG_APOPTOSIS",0.534583333333333,0.862019875148778,0.744240553789745,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92905196647579
+"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.53025,0.988659802229996,0.182327156492868,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.394335477996203
+"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.529916666666667,0.914248370703133,0.477770720338107,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.753096220193964
+"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.52925,0.76735426510955,0.846556426123929,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.999213161238356
+"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.52925,0.832234574121766,0.7940475067109,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.968950478899731
+"KEGG_REGULATION_OF_AUTOPHAGY",0.51675,0.96702732169732,0.318599502765129,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.575335024410815
+"KEGG_PYRUVATE_METABOLISM",0.513166666666667,1.19599390644034,0.026745781359501,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0945785775978492
+"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.505083333333333,1.22176098379149,0.00629151248263206,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0292555330442391
+"KEGG_SULFUR_METABOLISM",0.4995,1.44666189428064,2.8834712876383e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, HCC44",0.000107265131900145
+"KEGG_ARACHIDONIC_ACID_METABOLISM",0.499333333333333,1.26575815105797,0.00417677136115664,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.024277483536723
+"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.49225,0.724787006330449,0.99135428234984,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_LYSINE_DEGRADATION",0.45975,1.08796667103029,0.100513599347604,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.27146421146697
+"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.45525,1.04721137268983,0.275558524263209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.524107405623711
+"KEGG_RIBOFLAVIN_METABOLISM",0.437583333333333,1.30028545525647,0.0028348312314032,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0195288373718887
+"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.429166666666667,1.51441833018089,1.34955002666462e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.000313770381199524
+"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.426333333333333,1.06286194548093,0.143619606101405,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.356176623131485
+"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.412,0.959973863280568,0.555912435869098,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.833868653803646
+"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39925,1.08205252141054,0.226933557191868,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.458800452583558
+"KEGG_GALACTOSE_METABOLISM",0.382416666666667,1.16035946298263,0.0507775631792728,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.157410445855746
+"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.381833333333333,1.01490741479509,0.416290478907209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.686627504357003
+"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.37,1.26955009926566,0.241552912744442,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.47796640181347
+"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.365,0.968116634596172,0.600336099664643,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.879232397934045
+"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.363166666666667,1.00323085654058,0.519301279374631,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.791721622653125
+"KEGG_SMALL_CELL_LUNG_CANCER",0.358916666666667,0.867649118263969,0.943731678224006,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_ALZHEIMERS_DISEASE",0.358166666666667,0.929554324622419,0.669238502119766,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.915282069075563
+"KEGG_FATTY_ACID_METABOLISM",0.354333333333333,1.02587384775866,0.405930836397402,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.680953112192685
+"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.3525,1.31083398158299,0.00946191798560483,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.0409282964028488
+"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.348416666666667,0.743872479092697,0.999213161238356,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.339166666666667,0.931094159219857,0.723493096669306,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251
+"KEGG_NITROGEN_METABOLISM",0.339,1.19549495265274,0.0354634091883509,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.11572270366725
+"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.3375,0.904073659509103,0.881249808502836,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.322583333333333,0.943056679905906,0.73448508160118,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251
+"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.322583333333333,1.04987033470661,0.379890329637474,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.648253223051102
+"KEGG_LONG_TERM_DEPRESSION",0.320083333333333,0.81127446967812,0.992881235392838,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_OLFACTORY_TRANSDUCTION",0.315,0.874280483389835,0.953690880365227,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.3105,0.786003296315087,0.996198943201011,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.309333333333333,1.79860599219271,8.10053586511452e-10,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1648, H460, HCC44, A549",1.5066996709113e-07
+"KEGG_JAK_STAT_SIGNALING_PATHWAY",0.306916666666667,0.855172864857088,0.966891345898313,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_MTOR_SIGNALING_PATHWAY",0.30525,1.10630540950088,0.197312720155791,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414954652725718
+"KEGG_INSULIN_SIGNALING_PATHWAY",0.3015,0.965583337583133,0.767469942629711,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.945360326682955
+"KEGG_WNT_SIGNALING_PATHWAY",0.2925,0.943532386108905,0.851937140685304,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.28775,1.09179669477759,0.262957498050279,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.509480152472416
+"KEGG_PARKINSONS_DISEASE",0.287583333333333,1.11482387180734,0.160489998856461,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.377825235366307
+"KEGG_BUTANOATE_METABOLISM",0.287416666666667,1.14377735105565,0.13011616548941,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.327048740284192
+"KEGG_HUNTINGTONS_DISEASE",0.2855,1.04759234784945,0.296822232124013,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.541264070343788
+"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.281,1.14436755061872,0.113207051516311,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.29245154975047
+"KEGG_PRIMARY_IMMUNODEFICIENCY",0.28025,1.06666584398643,0.281686560678008,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.529229295819287
+"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.280083333333333,1.07041745962909,0.352450544891725,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.612671040652905
+"KEGG_N_GLYCAN_BIOSYNTHESIS",0.277333333333333,1.06797091663953,0.406375244373054,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.680953112192685
+"KEGG_TIGHT_JUNCTION",0.276416666666667,0.868400667720246,0.972872406410684,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_RETINOL_METABOLISM",0.274666666666667,1.0159725598776,0.506506914224674,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.785589984875929
+"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.27025,1.2747465434352,0.0175175011643979,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"A549, HCC15",0.0651651043315602
+"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.250916666666667,1.32457989623697,0.00909902061782124,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0402956627360655
+"KEGG_LEISHMANIA_INFECTION",0.243833333333333,1.07423527415666,0.276142611565181,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.524107405623711
+"KEGG_LONG_TERM_POTENTIATION",0.242333333333333,1.00751235799624,0.646188930598406,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205
+"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.241583333333333,1.00715968385747,0.678583512001726,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919231361206546
+"KEGG_PRION_DISEASES",0.239916666666667,0.973569482820198,0.812301128237938,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.981090973066601
+"KEGG_OXIDATIVE_PHOSPHORYLATION",0.238083333333333,1.09213522791851,0.247144074456024,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.483882082619162
+"KEGG_PATHWAYS_IN_CANCER",0.231166666666667,0.83136370263598,0.996313232939234,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_CELL_ADHESION_MOLECULES_CAMS",0.223916666666667,0.882907434490608,0.973843970930251,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_PEROXISOME",0.223833333333333,1.03663580291189,0.528050223036226,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.798514971420634
+"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.21025,0.92877134136743,0.913389731129389,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.209083333333333,1.36246404178294,0.00138040808921534,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0106981626914189
+"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.204166666666667,0.918985689208323,0.946055925044637,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_SPHINGOLIPID_METABOLISM",0.20275,1.01269425745923,0.687425674117467,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919231361206546
+"KEGG_TYPE_II_DIABETES_MELLITUS",0.201083333333333,1.10981197902522,0.286138204712022,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.532217060764361
+"KEGG_STARCH_AND_SUCROSE_METABOLISM",0.196416666666667,0.911158848373705,0.946888207906333,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.196166666666667,0.957382495361307,0.797039910062682,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.968950478899731
+"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.191166666666667,1.30139043357713,0.0144677380404855,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0555303641650227
+"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.188916666666667,1.43690389748447,0.000431357873981221,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.00391341324348491
+"KEGG_TRYPTOPHAN_METABOLISM",0.186,1.13953507265822,0.207733394423095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.424597927062589
+"KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.1765,0.821239473434681,0.997457802953366,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.17,1.3775385822018,0.00187024998002767,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0139146598514059
+"KEGG_PROPANOATE_METABOLISM",0.166666666666667,1.34942636522024,0.00341820436087332,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0227066432543728
+"KEGG_FOLATE_BIOSYNTHESIS",0.159833333333333,1.39932203281273,0.000412499562031675,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1648",0.00391341324348491
+"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.15625,0.960023875176597,0.922959320748554,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_VEGF_SIGNALING_PATHWAY",0.152916666666667,1.00859573470276,0.735733156747589,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251
+"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.14975,0.996067917089264,0.691894572951164,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919231361206546
+"KEGG_NON_HOMOLOGOUS_END_JOINING",0.142833333333333,1.49627475802914,1.22446234115451e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, H1703",0.000313770381199524
+"KEGG_GNRH_SIGNALING_PATHWAY",0.138166666666667,1.00859955413735,0.756241030392057,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.937738877686151
+"KEGG_ENDOCYTOSIS",0.138,1.01969585483302,0.690967933686218,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919231361206546
+"KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.133916666666667,1.02967801307305,0.709617789880614,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.922999363061497
+"KEGG_TGF_BETA_SIGNALING_PATHWAY",0.120416666666667,0.952269772541883,0.92165679067392,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_P53_SIGNALING_PATHWAY",0.119833333333333,1.0361028233752,0.615275040243121,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.889995455352405
+"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.11525,1.27101499347426,0.0269498097456237,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0945785775978492
+"KEGG_GAP_JUNCTION",0.11475,0.92768108989321,0.955761270126232,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_COLORECTAL_CANCER",0.113333333333333,1.04936936328733,0.61725491258312,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.889995455352405
+"KEGG_PPAR_SIGNALING_PATHWAY",0.1045,0.976940260572402,0.87749211149283,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_ACUTE_MYELOID_LEUKEMIA",0.09925,1.17302577860537,0.167986704572275,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.385747247536335
+"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.0965,1.21318195442623,0.0792350539049792,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.237705161714938
+"KEGG_ERBB_SIGNALING_PATHWAY",0.09275,1.01311527882162,0.73347718963101,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251
+"KEGG_PROTEIN_EXPORT",0.0808333333333334,1.3605329726607,0.00566496414091495,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0277285086897416
+"KEGG_GLIOMA",0.0746666666666667,1.01783382581328,0.731796143214532,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.92463761591251
+"KEGG_FOCAL_ADHESION",0.0729166666666667,0.892656959290464,0.984067631681609,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_PROSTATE_CANCER",0.065,0.984801595154162,0.865506518106912,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.0590833333333333,1.24789112712268,0.0317833641287381,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.107306485135393
+"KEGG_NOTCH_SIGNALING_PATHWAY",0.0584166666666667,1.16298178351506,0.156893667486884,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.377825235366307
+"KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.0521666666666666,1.04341770885466,0.642201876905927,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205
+"KEGG_MELANOGENESIS",0.04625,0.950312113800705,0.925367574526933,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_BASAL_CELL_CARCINOMA",0.0403333333333334,1.05262367732282,0.630672075296952,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205
+"KEGG_RENAL_CELL_CARCINOMA",0.0395833333333333,1.11696394166047,0.339992697115245,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602272777747006
+"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.0379166666666667,1.01578947875606,0.699579691555084,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.922849805881174
+"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.037,0.978491510624204,0.865445282094194,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_MELANOMA",0.0361666666666667,1.05180233481161,0.6375351509243,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205
+"KEGG_BASAL_TRANSCRIPTION_FACTORS",0.0290833333333333,1.30190332404196,0.0097505292275326,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0412181462800242
+"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.0199166666666667,0.956031899271276,0.924384489444331,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_CHRONIC_MYELOID_LEUKEMIA",0.0126666666666666,1.09718510357877,0.450379706907766,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.729171722886162
+"KEGG_LYSOSOME",0.00900000000000008,1.19592497484355,0.0877809320301828,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.251188513194062
+"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.00649999999999999,1.41954445317695,0.0119171257326067,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, HCC15",0.0471613911971242
+"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.00641666666666663,0.968380415326476,0.872451745403344,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_VIBRIO_CHOLERAE_INFECTION",0.000916666666666695,1.09969321823972,0.338036487531776,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602272777747006
+"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.031,1.03686529325831,0.632772697738134,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.896948814114205
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.04225,1.20752166364907,0.0834943715058576,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.244930108186151
+"KEGG_PANCREATIC_CANCER",-0.0475833333333334,1.08774198631287,0.472813214836201,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.75165177743191
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.0519166666666668,1.21322451331028,0.106685898879174,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.279487002697553
+"KEGG_DILATED_CARDIOMYOPATHY",-0.0535,0.909920526000136,0.968805279292055,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999213161238356
+"KEGG_ENDOMETRIAL_CANCER",-0.0724166666666667,1.11867937224157,0.295554169652486,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.541264070343788
+"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.09325,1.02480296332337,0.669234436109921,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.915282069075563
+"KEGG_THYROID_CANCER",-0.0981666666666667,1.20495317399273,0.0941710235271367,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265391066303749
+"KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.13075,1.19859244153678,0.0971475852293205,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.269693296308263
+"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.132833333333333,1.05591750997831,0.45083197920381,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.729171722886162
+"KEGG_ECM_RECEPTOR_INTERACTION",-0.136333333333333,1.08363322655637,0.517255367933033,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.791721622653125
+"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.141666666666667,1.18635640308952,0.100704465544198,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.27146421146697
+"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.155583333333333,1.376243005652,0.0082984260285914,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1648, HCC44",0.0376465180809268
+"KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.165416666666667,1.08005003742111,0.45715206423882,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.733019689210521
+"KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.184333333333333,1.46042835144247,0.0146289669036888,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0555303641650227
+"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.192916666666667,1.26959631797121,0.0397732491078706,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.125386853119727
+"KEGG_ADHERENS_JUNCTION",-0.220333333333333,1.12136080750402,0.238264989921619,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.476529979843237
+"KEGG_OTHER_GLYCAN_DEGRADATION",-0.2505,1.52869483844583,2.54193253950788e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.000455773719983634
+"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.292666666666667,1.09985266230886,0.180217714576813,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.394335477996203
+"KEGG_AXON_GUIDANCE",-0.316166666666667,1.05479027069438,0.346730221455237,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.608413407459189
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.316416666666667,1.4338357620119,0.000133179179107083,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1703",0.00145713690081867
+"KEGG_STEROID_BIOSYNTHESIS",-0.34275,1.45436328617778,1.86239428967547e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.000384894819866263
+"KEGG_RIBOSOME",-0.448833333333333,1.42171694109835,0.104518943866503,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H1648, H460",0.277721765130995
+"KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.561166666666667,1.48246335740908,7.97270759520263e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.000988615741805126
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.569666666666667,1.51132737163145,5.06720602382141e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC95, H1703",0.000725000246485218
+"KEGG_BLADDER_CANCER",-0.59425,1.02532293139106,0.121035286332093,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.308391277503689
diff --git a/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..75301dd
--- /dev/null
+++ b/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_results.csv	
@@ -0,0 +1,2233 @@
+"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H1650","Input","KEGG_ABC_TRANSPORTERS",0.21787,0.626,0.962,3673,1,"ABCG2, ABCA5, ABCB8, ABCC1, TAP2, ABCA12, ABCB9, ABCB11, ABCC6",0.0168249279621871,0,FALSE
+"H1650","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.25175,0.732,0.865,4849,0.984,"TCF7L1, MAP2K1, AKT2, STAT3, JUP, MTOR, TCF7L2, MAPK3, PIK3R3, RUNX1, AKT3, BAD, RAF1, SOS1, CCNA1, GRB2",0.0629838925351858,0.00700490156865849,FALSE
+"H1650","Input","KEGG_ADHERENS_JUNCTION",0.41444,1.19,0.209,5643,1,"TCF7L1, CDH1, SNAI1, CTNND1, ACTB, CSNK2A2, TJP1, ACTN4, RAC1, BAIAP2, SMAD2, NECTIN4, TGFBR2, PARD3, ERBB2, PTPN1, TCF7L2, AFDN, CTNNA1, NECTIN1, EGFR, PTPRJ, MAPK3, PTPRM, ACP1, EP300, SSX2IP, PTPRF, PTPN6, RHOA, NECTIN2, MET, CDC42, IQGAP1, ACTN1",0.679853713888946,0,FALSE
+"H1650","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.2253,-0.843,0.645,17522,0.891,"IRS2, PCK2, PRKCQ, PRKAG1, PRKAA2, PPARGC1A, RXRB, LEPR, IRS1, NFKBIE, CAMKK1, IKBKB",0.190440285364732,0.0501222959631252,FALSE
+"H1650","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.31265,0.906,0.608,2867,0.963,"GLS, ABAT, GOT2, GAD1, GPT2, GFPT1",0.216096420727265,0.0163737128754655,FALSE
+"H1650","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.25839,-0.993,0.413,14636,0.872,"FXYD4, KCNJ1, KRAS, PIK3CG, ATP1B2, PIK3R1, IGF1, FXYD2, PIK3CD, PRKCG, HSD11B1, IRS2, SGK1, NR3C2, IRS1, SLC9A3R2, INSR",0.384049948343599,0.0594835150674328,FALSE
+"H1650","Input","KEGG_ALLOGRAFT_REJECTION",0.40437,1.17,0.23,2640,1,"CD40, IL12A, IL12B",0.638272163982407,0,FALSE
+"H1650","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.34113,0.989,0.486,1909,0.963,"PLA2G12A, ACOX1, PLA2G4B",0.313363730737707,0.0163737128754655,FALSE
+"H1650","Input","KEGG_ALZHEIMERS_DISEASE",0.29454,0.867,0.689,4938,0.969,"CHP1, NDUFAB1, UQCRC2, CALM3, PPP3R1, PSENEN, CACNA1D, CYCS, PPP3CA, CYC1, CAPN1, UQCRFS1, NAE1, BID, GAPDH, MME, GNAQ, CASP7, NDUFS6, APP, NDUFB8, COX6B1, ADAM10, EIF2AK3, MAPK3, UQCR10, CASP8, NDUFA8, GRIN2A, SDHA, ITPR2, NDUFB1, BAD, NDUFV2, CALML6, COX6C, SDHB, NDUFB3, NDUFB9, CALM1, COX8A, NDUFB6, NDUFB7",0.161780778092374,0.0136762229492347,FALSE
+"H1650","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29986,-1.11,0.261,16497,0.782,"AARS2, MARS2, TARS2, CARS2, PARS2, FARS2, WARS2",0.583359492661719,0.106793246940152,FALSE
+"H1650","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.34794,1,0.445,6162,1,"NAGK, UGP2, PGM1, GPI, GFPT1, GNE, NANP, GALT, GMPPB, GMPPA, HK2, HK1, PMM2, FPGT, HEXA, NPL, UAP1, UXS1, CYB5R3, GFPT2, PGM2",0.351639989019068,0,FALSE
+"H1650","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.3911,1.14,0.264,5709,1,"CHP1, MAP3K5, PPP3R1, MAPK11, TOMM40, CYCS, PPP3CA, BID, RAC1, MAPK13, DERL1, GRIN2A, BCL2L1, BAD, CASP1, MAP2K3, SOD1, GPX1, RAB5A, NEFH, CCS",0.578396073130169,0,FALSE
+"H1650","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.25511,0.735,0.848,3229,1,"IFNA5, HSPA2, NFYC, IFI30, HSPA4, TAP2, HSPA1A, TAPBP, HSPA1B, NFYB",0.0716041477432862,0,FALSE
+"H1650","Input","KEGG_APOPTOSIS",0.34533,1,0.448,4883,1,"CHP1, PPP3R1, TRADD, ENDOD1, CYCS, PPP3CA, NGF, CAPN1, MAP3K14, BID, ENDOG, AKT2, CASP7, MYD88, IL1R1, PRKACG, IL1RAP, PRKAR1B, CASP8, PIK3R3, PRKACA, AKT3, BCL2L1, BAD, CFLAR, DFFA, PRKAR2A, EXOG",0.348721986001856,0,FALSE
+"H1650","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.20615,0.597,0.965,2208,0.995,"PTGES, CYP2E1, CYP4F3, PLA2G12A, PLA2G4B, GPX7",0.0154726866562074,0.00217691925427455,FALSE
+"H1650","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.23496,-0.791,0.712,17420,0.929,"ARG2, ALDH1B1, NAGS, GLUD2, ALDH2, PRODH, CPS1, ODC1, GLS2, ACY1, MAOA, AMD1",0.147520006363144,0.0319842860063582,FALSE
+"H1650","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.39501,1.17,0.221,2136,1,"TCF7L1, ITGA4, DAG1, CACNA1D, CACNG4, ITGA1, DSC2, SLC8A1, ITGA6, ACTB, ITGB8, DSG2, JUP, PKP2, DSP, ACTN4",0.655607726314889,0,FALSE
+"H1650","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.27217,-1,0.38,16230,0.909,"MIOX, UGT2B7, ALDH1B1, ALDH2, UGDH",0.42021640338319,0.0414361167780325,FALSE
+"H1650","Input","KEGG_ASTHMA",-0.29495,-1.08,0.342,13707,0.74,"IL4, IL13, PRG2, IL10, FCER1G, EPX, RNASE3, IL5, TNF",0.465973893943865,0.130768280269024,FALSE
+"H1650","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.31921,0.922,0.604,1349,0.977,"IFNA5, CD40",0.218963061378868,0.0101054362812269,FALSE
+"H1650","Input","KEGG_AXON_GUIDANCE",0.37843,1.12,0.29,5824,1,"CHP1, NTN1, SEMA3E, SEMA3D, PAK4, PPP3R1, RHOD, PPP3CA, NTN4, PTK2, SEMA5A, NFAT5, SRGAP2, EFNA5, LIMK2, RAC1, SRGAP1, NFATC1, PLXNA2, ROBO3, PLXNB1, SEMA3F, SEMA4F, EFNA1, RASA1, PAK6, NFATC3, MAPK3, SEMA7A, SLIT3, EPHB3, PLXNB2, ROBO1, EPHA1, GNAI1, SEMA6B, ITGB1, EPHB4, RHOA, EPHA2, ABLIM1, MET, UNC5C, CFL2, PAK2, EFNA2, ROCK1, UNC5B, UNC5A, CDC42, SEMA3C, SEMA4B, CFL1, LIMK1, CDK5, NCK2",0.537602002101044,0,FALSE
+"H1650","Input","KEGG_BASAL_CELL_CARCINOMA",0.25186,0.732,0.877,3854,0.984,"TCF7L1, WNT9A, GLI3, WNT7B, WNT7A, WNT6, FZD6, TCF7L2, FZD9, FZD2",0.0570004066339595,0.00700490156865849,FALSE
+"H1650","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.33366,-1.24,0.154,18005,0.774,"GTF2F2, STON1, GTF2F1, GTF2H1, TBPL1, GTF2H2",0.812479279163537,0.111259039317107,FALSE
+"H1650","Input","KEGG_BASE_EXCISION_REPAIR",0.27924,0.818,0.771,6434,0.972,"XRCC1, POLE4, POLD1, NEIL3, SMUG1, LIG1, POLE, TDG, POLD2, PARP3, APEX2, MBD4, UNG, POLD3, LIG3",0.112945621949043,0.0123337350737254,FALSE
+"H1650","Input","KEGG_BETA_ALANINE_METABOLISM",0.38435,1.12,0.262,6187,1,"ABAT, GAD1, SMS, ECHS1, UPB1, SRM, HADHA, DPYD, ALDH3A2, ALDH9A1",0.581698708680255,0,FALSE
+"H1650","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.54217,1.55,0.035,5019,0.766,"ACOT4, SCD5, HACD2, ACAA1, TECR, ACOX1, HACD1, ELOVL6, HADHA, ACOT2, YOD1, ACOT1",1.45593195564972,0.115771230367396,FALSE
+"H1650","Input","KEGG_BLADDER_CANCER",0.29146,0.847,0.7,4165,0.971,"E2F1, CDH1, MAP2K1, TYMP, DAPK2, ERBB2, EGF, DAPK1, EGFR, MAPK3, RAF1, CDKN1A",0.154901959985743,0.0127807700919951,FALSE
+"H1650","Input","KEGG_BUTANOATE_METABOLISM",0.32002,0.936,0.567,7337,0.979,"ABAT, ACSM1, GAD1, ECHS1, HADHA, OXCT1, ACSM4, HMGCS1, ALDH3A2, PDHA1, ACAT2, AACS, ALDH9A1, PDHB, OXCT2, ALDH5A1, HADH",0.246416941107093,0.00921730819686218,FALSE
+"H1650","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35091,1.02,0.406,4157,1,"CHP1, PPP3R1, MAP2K1, PPP3CA, VAV3, PLCG2, NFAT5, DAPP1, LILRB3, AKT2, MALT1, RAC1, VAV1, NFATC1, NFKBIB, NFATC3, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1",0.391473966422806,0,FALSE
+"H1650","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.31627,0.917,0.609,4692,0.962,"ADORA2A, TNNC1, CHP1, CAMK2G, PLCD1, PLCE1, CALM3, GNAS, PPP3R1, CACNA1D, PPP3CA, P2RX2, PLCG2, SLC8A1, PHKB, RYR1, ADRA1B, SPHK2, PHKG2, GNAQ, P2RX5, OXTR, CAMK2D, PRKACG, HTR6, ADCY1, MYLK2, ERBB2, P2RX4, ADCY7, GNA15, PTK2B, ADRB1, EGFR, ADORA2B, PRKACA, GRIN2A, ITPR2, CALML6, PHKG1, TBXA2R, TRPC1, PLCD3, PTAFR, CALM1",0.215382707367125,0.0168249279621871,FALSE
+"H1650","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.31587,0.916,0.616,5320,0.955,"TNNC1, UQCRC2, CACNA1D, CACNG4, CYC1, SLC8A1, TNNI3, UQCRFS1, SLC9A1, TPM2, TPM1, COX6B1, UQCR10, CACNA2D2, COX6C, CACNB1, MYL3, COX8A, TNNT2, CACNG1, ATP1B1",0.210419287835575,0.0199966284162537,FALSE
+"H1650","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.30497,0.886,0.645,2668,0.959,"ITGA4, GLG1, CDH3, ITGB2, CDH1, PVR, SDC4, NFASC, SDC1, CD226, ITGA6, CD40, ITGB8, F11R, OCLN, CLDN7, CLDN23, CLDN4, SDC2",0.190440285364732,0.0181813928293364,FALSE
+"H1650","Input","KEGG_CELL_CYCLE",0.28974,0.842,0.725,8040,0.974,"E2F1, YWHAZ, PLK1, RBL2, E2F4, RAD21, ORC6, YWHAB, CHEK2, CCNE1, SFN, PKMYT1, ANAPC2, SMAD2, CCND3, ANAPC10, CDC23, CHEK1, SMC1B, RBL1, SKP2, RBX1, ANAPC7, CDKN1A, CCNB1, MAD1L1, CDC25A, CDC25B, EP300, CDKN2D, CCNE2, CCNA1, CDC20, CCNA2, HDAC1, CDC6, MCM5, YWHAE, BUB1, MAD2L2, ZBTB17, CUL1, CDC14A, PRKDC, YWHAQ, ESPL1, CDC45, CDK7, WEE2, TGFB3, CDK2, CDC7, MCM6, GADD45A, ORC3, E2F2, SMAD4, TGFB2, BUB1B, CCNB2, MAD2L1, MCM4, CREBBP, CDC14B, TGFB1, DBF4, GADD45B, ORC1, PTTG1, YWHAG, CCNH, CDKN1B, ABL1, YWHAH",0.139661993429006,0.0114410431213845,FALSE
+"H1650","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.328,0.948,0.543,4238,1,"CCR3, CCR2, CCL5, CCL28, STAT1, BCAR1, GNG13, MAP2K1, VAV3, STAT2, PRKCD, PTK2, RAP1A, GSK3A, PXN, GRK3, AKT2, STAT3, TIAM1, CXCR1, RAC1, VAV1, CCR1, PRKACG, ADCY1, PARD3, NFKBIB, ADCY7, CXCL16, PTK2B, VAV2, MAPK3, PIK3R3, CCR5, PRKACA, CCL17, AKT3, PRKCZ, CCR4, RAF1, GNG10, SOS1, TIAM2",0.265200170411153,0,FALSE
+"H1650","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.21409,-0.779,0.769,17589,0.917,"SHC3, STAT5B, MYC, CDK4, SHC2, RB1, TP53, CDKN2A, GAB2, HDAC2, MECOM, IKBKB",0.114073660198569,0.0376306643299789,FALSE
+"H1650","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.44307,-1.63,0.0575,15827,0.422,"PER2, BHLHE41, ARNTL, NPAS2",1.24033215531037,0.374687549038326,FALSE
+"H1650","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.44968,1.29,0.129,6590,1,"PC, MDH1, OGDH, ACO2, IDH3B, SDHA, SUCLG1, MDH2, SDHB, IDH2, IDH3A, PDHA1, IDH1, PDHB, SDHC",0.889410289700751,0,FALSE
+"H1650","Input","KEGG_COLORECTAL_CANCER",0.26134,0.767,0.832,3976,0.997,"TCF7L1, MAP2K1, CYCS, AKT2, RAC1, SMAD2, TGFBR2, TCF7L2, MAPK3, PIK3R3, AKT3, BAD, RAF1",0.0798766737092761,0.00130484168834428,FALSE
+"H1650","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.34221,-1.27,0.143,13893,0.807,"FGA, SERPIND1, F7, CPB2, FGB, F2, SERPING1, F13A1, C6, F5, C4BPA, C7, CR2, MASP1, C1S, THBD, SERPINF2, C4B, PLG, F10, VWF, F2R, C4A, A2M, KLKB1, SERPINA5, MASP2, C3AR1, BDKRB1, C1R, PROS1, CFH, BDKRB2, C2, SERPINE1, PLAT",0.844663962534938,0.0931264652779296,FALSE
+"H1650","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.27313,0.79,0.786,4360,0.975,"LDHAL6B, GOT2, SMS, ADI1, TAT, AHCYL2, AHCY, CBS, SRM, DNMT1, DNMT3B, ENOPH1",0.104577453960592,0.0109953843014632,FALSE
+"H1650","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.27248,0.792,0.789,3741,0.979,"CCR3, IFNL1, CCR2, IFNL3, CCL5, CSF1R, IL20RB, IFNA5, CCL28, PDGFB, IFNL2, IL6, IFNB1, BMP7, CD40, IL12A, PDGFA, PDGFC, CXCR1, IL9R, CTF1, CCR1, IL1R1, TGFBR2, TNFRSF25, IL12B, OSMR, IL18, PRLR, EGF, CXCL16, IL1RAP, EGFR, ACVR2A, TNFRSF12A, CCR5, TNFRSF18, CCL17",0.10292299679058,0.00921730819686218,FALSE
+"H1650","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.3743,1.09,0.32,3310,0.988,"CCL5, IFNA5, DDX58, IRF3, POLR3H, IL6, IFNB1, PYCARD, POLR3K, NFKBIB, IL18, ADAR",0.494850021680094,0.00524305541237188,FALSE
+"H1650","Input","KEGG_DILATED_CARDIOMYOPATHY",0.38677,1.12,0.286,5099,1,"TNNC1, ITGA4, DAG1, GNAS, CACNA1D, CACNG4, ITGA1, SLC8A1, ITGA6, ACTB, TNNI3, ITGB8, TPM2, TPM1, PRKACG, ADCY1, ADCY7, ADRB1, PRKACA, CACNA2D2, ITGAV, LMNA, CACNB1, ITGA3, ITGB1, ITGB4, MYL3, ADCY6, TNNT2, CACNG1",0.543633966870957,0,FALSE
+"H1650","Input","KEGG_DNA_REPLICATION",0.35107,1.02,0.438,6811,1,"POLE4, POLD1, DNA2, LIG1, POLE, POLA2, RNASEH2A, POLD2, RPA3, RNASEH2C, RPA1, MCM5, RNASEH1, POLD3, RFC2, MCM6, RFC5",0.3585258894959,0,FALSE
+"H1650","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43449,1.27,0.144,5338,1,"ETV7, MAP2K1, NOTCH3, SPIRE1, EGFR, MAPK3, SOS1, ETS2, GRB2, SPIRE2",0.84163750790475,0,FALSE
+"H1650","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.23165,-0.823,0.663,16157,0.897,"GSTM3, GSTO1, ALDH3A1, CYP3A4, UGT2B7, MAOB, GSTT2, GSTM1, CYP3A5, MAOA, GSTM2, GSTZ1, GSTA4, GSTP1",0.178486471595227,0.0472075569559079,FALSE
+"H1650","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.3639,1.05,0.382,3951,1,"UGT2B17, XDH, CDA, TYMP, TK1, UPP1, CES2, UPB1, UCKL1, NAT2, TK2",0.417936637088291,0,FALSE
+"H1650","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.31659,0.929,0.566,4794,0.989,"CHAD, ITGA4, DAG1, SDC4, ITGA1, LAMA5, SDC1, ITGA6, ITGB8, COL5A1, LAMA3, SDC2, HSPG2, LAMB2, LAMB1, LAMC2, LAMB3, ITGAV, TNC, ITGA3, ITGB1, COL11A2, ITGB4",0.247183568811729,0.0048037084028206,FALSE
+"H1650","Input","KEGG_ENDOCYTOSIS",0.45307,1.31,0.125,5492,1,"CSF1R, HSPA2, STAMBP, SH3GL2, CBLC, RAB22A, VPS28, VPS4A, EHD2, DNM3, EPN3, AGAP1, FGFR2, SH3GLB2, EHD1, EPN1, AP2S1, ITCH, NEDD4L, CHMP4B, CHMP2A, GRK3, AP2A1, CHMP5, DNAJC6, VPS37B, CXCR1, IQSEC2, CHMP3, RAB11FIP4, HSPA1A, ARAP2, PLD2, VPS4B, PARD3, HSPA1B, ASAP3, ACAP1, PARD6B, ASAP2, VTA1, ARFGAP1, PSD4, EGF, WWP1, CLTB, RAB11A, PIP5K1A, ADRB1, EGFR, CHMP6, RUFY1, TFRC, DAB2, EPN2, CCR5, PRKCI, RAB4A, PRKCZ, IQSEC1, SNF8, EPS15, SH3KBP1, NEDD4, CHMP2B, PLD1, PSD, ASAP1, RAB5C, DNM1, USP8, EHD3, LDLRAP1, CHMP4C, EHD4, SH3GLB1, ARFGAP3, GRK5, MET, RAB11FIP5, STAM2, SH3GL1, ARRB1, CDC42, DNM2, RAB5A",0.903089986991944,0,FALSE
+"H1650","Input","KEGG_ENDOMETRIAL_CANCER",0.34995,1.02,0.434,4157,1,"TCF7L1, CDH1, MAP2K1, AKT2, ERBB2, TCF7L2, EGF, PTEN, CTNNA1, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1",0.362510270487489,0,FALSE
+"H1650","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37836,1.09,0.313,3705,0.988,"CCL5, ATP6V0D1, MAPK11, ATP6V1C1, PLCG2, NOD1, MAP3K14, TJP1, CXCR1, F11R, RAC1, MAPK13, ATP6V0A1, ADAM10, ATP6V0C, EGFR, ATP6AP1",0.504455662453552,0.00524305541237188,FALSE
+"H1650","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.33392,0.979,0.485,4165,0.947,"CAMK2G, GAB1, PAK4, CBLC, MAP2K1, PLCG2, PTK2, TGFA, AKT2, MTOR, CAMK2D, ERBB2, EGF, EGFR, PAK6, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CDKN1A",0.314258261397736,0.0236500209967266,FALSE
+"H1650","Input","KEGG_ETHER_LIPID_METABOLISM",0.38083,1.1,0.316,6715,1,"PLA2G12A, PAFAH1B3, PLA2G4B, LPCAT2, PAFAH1B1, PLD2, LPCAT1, PLA2G7, PLD1, CHPT1, AGPS, PLA2G10, PLA2G4E, LPCAT4, PAFAH1B2, PLPP1",0.500312917381596,0,FALSE
+"H1650","Input","KEGG_FATTY_ACID_METABOLISM",0.23978,0.693,0.903,6379,0.989,"ACAA1, ACOX1, ACSL1, ECHS1, HADHA, ACSL3, CPT1A, ECI1, ALDH3A2, ACAT2, ACADVL, HADHB, CPT1B, ALDH9A1, ACAA2, ACOX3",0.0443122496864942,0.0048037084028206,FALSE
+"H1650","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.29266,0.85,0.7,4400,0.974,"MAPK11, MAP2K1, VAV3, PRKCD, PLCG2, PLA2G12A, AKT2, PLA2G4B, RAC1, VAV1, MAPK13, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1, PRKCE, MAP2K3",0.154901959985743,0.0114410431213845,FALSE
+"H1650","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.34365,0.998,0.445,5642,0.985,"VASP, DNM3, MAP2K1, VAV3, PRKCD, PLCG2, AKT2, PLA2G4B, SPHK2, LIMK2, RAC1, VAV1, PLD2, ASAP3, ASAP2, ARPC3, PIP5K1A, VAV2, MAPK3, PIK3R3, AKT3, ARPC5L, RAF1, PRKCE, PLD1, ASAP1, DNM1, SCIN, CFL2, CDC42, DNM2, PLCG1, CFL1, PLA2G4F, LIMK1",0.351639989019068,0.00656376950238827,FALSE
+"H1650","Input","KEGG_FOCAL_ADHESION",0.3476,1.01,0.448,5345,1,"CHAD, ITGA4, PAK4, ARHGAP35, PDGFB, MYL9, VASP, BCAR1, MAP2K1, ITGA1, VAV3, LAMA5, PTK2, RAP1A, ITGA6, ACTB, PXN, AKT2, PDGFA, FLNB, PDGFC, ITGB8, RAPGEF1, PDGFD, COL5A1, ACTN4, RAC1, VAV1, LAMA3, MYLK2, ERBB2, CCND3, PPP1CB, EGF, PTEN, EGFR, LAMB2, PAK6, VAV2, MAPK3, PIK3R3, AKT3, ARHGAP5, LAMB1, CAV2, MYL5, LAMC2, BAD, RAF1, LAMB3, SOS1, ITGAV, MYL7, TNC, ITGA3, ITGB1, MYL12B, COL11A2, ITGB4, GRB2, RHOA, CAV1, LAMC1, MET, PAK2, ROCK1, CDC42",0.348721986001856,0,FALSE
+"H1650","Input","KEGG_FOLATE_BIOSYNTHESIS",0.59623,1.72,0.014,771,0.512,"ALPP, SPR",1.85387196432176,0.290730039024169,FALSE
+"H1650","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.3083,-1.18,0.247,17725,0.671,"PFKFB1, PFKFB3, GMDS, PFKM, SORD, ALDOC, KHK, MTMR6",0.607303046740334,0.173277479831008,FALSE
+"H1650","Input","KEGG_GALACTOSE_METABOLISM",0.34964,1.02,0.424,7455,1,"B4GALT1, UGP2, PGM1, B4GALT2, GALT, HK2, HK1, AKR1B1, GLB1, PGM2, PFKP, PFKL, GALK1, MGAM",0.372634143407267,0,FALSE
+"H1650","Input","KEGG_GAP_JUNCTION",0.31075,0.898,0.628,6281,0.965,"PDGFB, GNAS, MAP2K1, TJP1, PDGFA, PDGFC, PDGFD, GNAQ, TUBA4A, PRKACG, ADCY1, ADCY7, TUBB8, EGF, ADRB1, EGFR, MAPK3, PRKACA, ITPR2, RAF1, GUCY1B1, SOS1, GJD2, GNAI1, GUCY1A1, ADCY6, GRB2, TUBB6, GUCY1A2, MAPK7, HRAS, MAP3K2, TUBA8, PRKACB, SRC, TUBB4B",0.202040356262804,0.0154726866562074,FALSE
+"H1650","Input","KEGG_GLIOMA",0.37403,1.09,0.33,4849,0.988,"CAMK2G, E2F1, CALM3, PDGFB, MAP2K1, PLCG2, TGFA, AKT2, PDGFA, MTOR, CAMK2D, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, RAF1, SOS1, CDKN1A, CALML6, CALM1, GRB2",0.481486060122112,0.00524305541237188,FALSE
+"H1650","Input","KEGG_GLUTATHIONE_METABOLISM",-0.23609,-0.857,0.634,16990,0.899,"PGD, GSTT2, GPX3, GSTM1, GPX2, ODC1, RRM1, GSTM2, GSTZ1, GSTA4, GSTP1",0.197910742118267,0.0462403082667712,FALSE
+"H1650","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.22898,-0.88,0.602,16976,0.884,"AGPAT1, DGKI, ALDH1B1, MBOAT1, ALDH2, DGAT2, GPAT4, DGKG, AGPAT3, AKR1A1",0.220403508742175,0.0535477349869269,FALSE
+"H1650","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.25138,0.736,0.86,3291,1,"ACHE, CHKA, LCAT, CDS1, PLA2G12A, PLA2G4B, MBOAT7, LPCAT2, PLD2, DGKE, PLA2G15, DGKA, CHKB, ETNK2, LPCAT1",0.0655015487564323,0,FALSE
+"H1650","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.25031,-0.901,0.538,17033,0.917,"MAOB, AMT, SARDH, CTH, MAOA, SHMT2",0.269217724333611,0.0376306643299789,FALSE
+"H1650","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.2593,0.756,0.846,6578,1,"ALDH3B2, PGAM1, PGM1, GAPDH, FBP2, GALM, PGAM4, LDHAL6B, ACSS2, GPI, ALDOA, ACSS1, HK2, HK1, ALDH1A3, ALDH3B1, ALDH3A2, PDHA1, ENO1, PGM2, ALDH9A1, PKM, PFKP, PDHB",0.0726296369609765,0,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.46894,1.38,0.0727,4591,1,"CHST14, XYLT1, CHST7, CHST12, B4GALT7, CHPF, DSE, CHST11, CHST15, CSGALNACT1, CHST3",1.13846558914096,0,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.39462,1.14,0.239,3145,1,"XYLT1, NDST1, EXT2, HS2ST1, B4GALT7, EXT1",0.621602099051862,0,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.53584,1.56,0.0371,2510,0.864,"CHST6, B4GALT4, B4GALT1, ST3GAL1, B4GALT2, B3GNT2",1.43062609038495,0.0634862575211067,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.35799,1.05,0.383,764,1,"HPSE, GALNS",0.416801226031377,0,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.34124,0.982,0.467,5398,0.949,"ST6GALNAC5, ST3GAL1, B4GALNT1, B3GALT4, HEXA, GLB1",0.330683119433888,0.0227337875727074,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.46931,1.36,0.0791,1325,1,"FUT9, FUT1, ST3GAL1",1.10182351650232,0,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62171,1.78,0.00867,2766,0.527,"B3GNT3, B4GALT4, B4GALT1, FUT9, FUT1, FUT3, ST3GAL4, B4GALT2, B3GNT2, ABO",2.06198090252379,0.278189384787453,FALSE
+"H1650","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.45711,1.32,0.111,4292,1,"GPAA1, PIGQ, PIGT, PIGO, PIGK, PIGG, PIGX, GPLD1, PIGU, PIGV, PIGN, PIGL",0.954677021213343,0,FALSE
+"H1650","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.57196,1.68,0.0122,4273,0.503,"MDH1, MTHFD2, ACO2, PGP, GRHPR, MTHFD1L, MDH2",1.91364016932525,0.298432014944073,FALSE
+"H1650","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.33254,0.958,0.529,6405,0.992,"CAMK2G, CALM3, GNAS, CACNA1D, MAPK11, MAP2K1, PRKCD, PLA2G12A, PLA2G4B, GNAQ, PLD2, CAMK2D, PRKACG, ADCY1, MAPK13, ADCY7, PTK2B, EGFR, MAPK3, PRKACA, ITPR2, RAF1, SOS1, CALML6, PLD1, MAP2K3, CALM1, ADCY6, GRB2, CDC42, MMP2, MAPK7, CGA, HRAS, PLA2G10, MAP3K2, PRKACB, SRC, PLA2G4E, HBEGF",0.276544327964814,0.00348832784582135,FALSE
+"H1650","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.24724,-0.889,0.608,11132,0.903,"IFNG, FASLG, KIR3DL2, IL2, FAS, CD28, KIR3DL1, KIR2DL3, PRF1, KLRD1, GZMB, CD86, TNF, IL1B, IL1A",0.216096420727265,0.0443122496864942,FALSE
+"H1650","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.2994,0.861,0.692,3717,0.966,"BMP5, WNT9A, BMP7, GLI3, WNT7B, WNT7A, WNT6, PRKACG, PRKACA, GAS1",0.159893905543242,0.0150228735845067,FALSE
+"H1650","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.27752,0.809,0.767,3762,0.981,"CSF1R, ITGA4, ITGA1, IL6, ANPEP, ITGA6, MME, IL9R, IL1R1, CD14, TFRC, CD59, CD9, CD55",0.115204636051019,0.0083309926200515,FALSE
+"H1650","Input","KEGG_HISTIDINE_METABOLISM",-0.35664,-1.35,0.107,15605,0.718,"DDC, HAL, AOC1, AMDHD1, ALDH3A1, MAOB, ACY3, ALDH1B1, ALDH2, HNMT, METTL2B, MAOA",0.97061622231479,0.1438755557577,FALSE
+"H1650","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.49845,1.45,0.043,6516,1,"POLD1, RAD51, XRCC3, POLD2, RPA3, NBN, RPA1, RAD52, EME1, XRCC2, RAD51C, RAD54B, POLD3, BLM",1.36653154442041,0,FALSE
+"H1650","Input","KEGG_HUNTINGTONS_DISEASE",0.21549,0.624,0.948,5129,1,"DNAI1, NDUFAB1, UQCRC2, POLR2K, CYCS, CYC1, POLR2I, POLR2C, AP2S1, UQCRFS1, DCTN1, DNAL1, AP2A1, DNAL4, GNAQ, NDUFS6, PPARG, NDUFB8, TAF4, TBPL2, TGM2, COX6B1, HAP1, CLTB, UQCR10, CASP8, NDUFA8, HTT, POLR2A, SDHA, NDUFB1, NDUFV2, COX6C, SDHB, EP300, NDUFB3, NDUFB9, SOD1, COX8A, NDUFB6, HDAC1, NDUFB7, TBP, CREB3, VDAC2",0.0231916626619338,0,FALSE
+"H1650","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.37839,1.11,0.29,2500,1,"TNNC1, ITGA4, DAG1, CACNA1D, CACNG4, ITGA1, IL6, SLC8A1, PRKAA1, ITGA6, PRKAG2, ACTB, TNNI3, ITGB8, TPM2, TPM1",0.537602002101044,0,FALSE
+"H1650","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.34387,0.992,0.478,5527,0.992,"PLCD1, PLCE1, PLCG2, PIK3C2B, INPP4B, IMPA2, INPP5A, MINPP1, INPP1, ITPK1, PIP4K2C, INPP5E, PTEN, PIP5K1A, SYNJ1, INPP4A, INPPL1, PLCD3, IPPK, PIK3C2G, ISYNA1, CDIPT, PLCG1",0.320572103387881,0.00348832784582135,FALSE
+"H1650","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.28638,0.834,0.735,4861,0.974,"CBLC, CALM3, GYS1, MAP2K1, PRKAA1, PPP1R3C, PRKAG2, PHKB, PPP1R3D, AKT2, RAPGEF1, FBP2, SOCS1, MTOR, PHKG2, SH2B2, PRKACG, PTPN1, PPP1CB, PRKAR1B, MAPK3, FLOT2, PIK3R3, PRKACA, AKT3, PRKCI, PRKCZ, BAD, RAF1, SOS1, CALML6, PHKG1, TSC1, HK2, HK1, PTPRF, CALM1, RPTOR, GRB2, PRKAR2A",0.133712660915805,0.0114410431213845,FALSE
+"H1650","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.39617,1.13,0.262,1524,1,"ITGA4, CCL28, IL6, CD40, MAP3K14",0.581698708680255,0,FALSE
+"H1650","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30651,0.899,0.62,6363,0.972,"IFNL1, IFNL3, IL20RB, IFNA5, CBLC, STAT1, IFNL2, STAT4, STAT2, IL6, IFNB1, IL12A, AKT2, STAT3, IL9R, SOCS1, CTF1, IRF9, IL12B, CCND3, OSMR, SPRED2, PRLR, PIAS1, PIK3R3, AKT3, BCL2L1, TYK2, IFNLR1, SOS1, EP300, IL11RA, PTPN6, GRB2, JAK1, STAM2, SPRY3, IL3RA, JAK2, PIM1, IFNE, CLCF1, IL22, CSF3R, PIK3CB, IL4R, STAM, IL15",0.207608310501746,0.0123337350737254,FALSE
+"H1650","Input","KEGG_LEISHMANIA_INFECTION",0.36569,1.05,0.366,2960,1,"ITGA4, ITGB2, STAT1, FCGR3B, MAPK11, IL12A, NCF4, MYD88, TAB2, IL12B, NFKBIB, MAPK13",0.436518914605589,0,FALSE
+"H1650","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.4217,1.22,0.181,5643,1,"ITGA4, ARHGAP35, ITGB2, MYL9, CTNND1, VASP, MAPK11, BCAR1, VAV3, RASSF5, PLCG2, PTK2, RAP1A, ACTB, PXN, F11R, OCLN, ACTN4, RAC1, CLDN7, VAV1, NCF4, CLDN23, CLDN4, MAPK13, AFDN, PTK2B, CTNNA1, VAV2, PIK3R3, ARHGAP5, MYL5, MYL7, GNAI1, CLDN9, ITGB1, MYL12B, RHOA, EZR, CLDN8, ESAM, ROCK1, CDC42, MMP2, PLCG1, CLDN1, ACTN1",0.742321425130815,0,FALSE
+"H1650","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.27111,0.792,0.797,6187,0.979,"ECHS1, HADHA, YOD1, ALDH3A2, ALDH9A1",0.0985416786038876,0.00921730819686218,FALSE
+"H1650","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.2528,0.718,0.879,1909,0.992,"CYP2E1, PLA2G12A, PLA2G4B",0.0560111249262281,0.00348832784582135,FALSE
+"H1650","Input","KEGG_LONG_TERM_DEPRESSION",0.23816,0.685,0.902,4678,0.983,"GNAO1, GNAS, PPP2R1A, MAP2K1, PLA2G12A, RYR1, PLA2G4B, GNAQ, MAPK3, ITPR2, RAF1, GUCY1B1, GNAI1, GUCY1A1, GNA12",0.0447934624580583,0.00744648216786438,FALSE
+"H1650","Input","KEGG_LONG_TERM_POTENTIATION",0.38026,1.11,0.298,4692,1,"CHP1, CAMK2G, CALM3, PPP3R1, MAP2K1, PPP3CA, RAP1A, RPS6KA1, GNAQ, CAMK2D, PRKACG, ADCY1, PPP1CB, MAPK3, PRKACA, GRIN2A, ITPR2, RAF1, CALML6, EP300, CALM1",0.525783735923745,0,FALSE
+"H1650","Input","KEGG_LYSINE_DEGRADATION",0.33936,0.991,0.472,6687,0.982,"BBOX1, OGDH, PLOD2, KMT5A, KMT5C, SETD2, ECHS1, HADHA, PLOD1, AASDHPPT, AADAT, NSD2, KMT5B, ALDH3A2, SETD1A, ACAT2, ALDH9A1, SETD1B, NSD1, PLOD3, TMLHE, EHMT1",0.326058001365912,0.00788851221305034,FALSE
+"H1650","Input","KEGG_LYSOSOME",0.32758,0.943,0.552,5502,0.981,"AP1G1, AP3S1, GGA2, CTSV, ATP6V0D1, GALNS, MFSD8, GM2A, AP4E1, MANBA, LAPTM4A, CTSA, ARSA, AP1M2, GNPTAB, DNASE2, ACP2, CTSH, PPT1, ABCB9, PLA2G15, AP1S1, ATP6V0A1, LAMP3, ATP6V0C, CLTB, CTSZ, GALC, ATP6AP1, AP4M1, PPT2, AP1B1, NAGPA, CTSL, CD68, ATP6V0A4, HEXA, GLB1, PSAP, NAGLU, SLC11A1",0.258060922270801,0.0083309926200515,FALSE
+"H1650","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.30049,0.879,0.675,4157,0.967,"CHP1, DUSP14, NTF4, HSPA2, STK3, MAP3K5, HSPB1, PDGFB, PPP3R1, CACNA1D, CACNG4, MAPK11, MAP2K1, PPP3CA, FGFR2, TAOK3, RAP1A, PLA2G12A, NGF, MAP3K14, FGF11, FGF2, MAPK8IP2, JUND, AKT2, PDGFA, FLNB, PLA2G4B, MAPKAPK3, RPS6KA1, RAC1, MAP3K6, MAP3K8, ECSIT, HSPA1A, PPP5C, MAP4K2, IL1R1, TGFBR2, TAB2, PRKACG, RPS6KA4, RASGRP4, HSPA1B, RRAS, CD14, MAPK13, NF1, MAP3K20, TAOK2, EGF, NFKB2, MAPK8IP3, EGFR, STK4, RASA1, MAPK3, DUSP9, PRKACA, AKT3, RAF1, CACNA2D2, MAP4K3, RAPGEF2, SOS1",0.170696227168975,0.0145735259169983,FALSE
+"H1650","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.50536,-1.87,0.0385,15732,0.276,"HNF4A, BHLHA15, HNF1A, HHEX, ONECUT1, FOXA3, HNF1B, FOXA2, GCK, HNF4G",1.4145392704915,0.559090917934782,FALSE
+"H1650","Input","KEGG_MELANOGENESIS",0.35633,1.04,0.385,5327,1,"TCF7L1, CAMK2G, GNAO1, CALM3, GNAS, WNT9A, MAP2K1, WNT7B, GNAQ, WNT7A, MITF, WNT6, CAMK2D, PRKACG, ADCY1, FZD6, TCF7L2, ADCY7, FZD9, MAPK3, PRKACA, FZD2, RAF1, CALML6, EP300, GNAI1, CALM1, FZD1, ADCY6, CREB3, KITLG, WNT9B",0.414539270491499,0,FALSE
+"H1650","Input","KEGG_MELANOMA",0.33754,0.983,0.502,4165,0.957,"E2F1, CDH1, PDGFB, MAP2K1, FGF11, FGF2, AKT2, PDGFA, PDGFC, PDGFD, MITF, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, CDKN1A",0.299296282854981,0.0190880622231565,FALSE
+"H1650","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.25715,-0.943,0.484,16157,0.9,"GSTM3, GSTO1, ALDH3A1, CYP3A4, UGT2B7, GSTT2, GSTM1, CYP3A5, AKR1C2, AKR1C1, AKR1C3, GSTM2, GSTZ1, GSTA4, GSTP1",0.315154638355588,0.0457574905606751,FALSE
+"H1650","Input","KEGG_MISMATCH_REPAIR",0.43736,1.26,0.137,6811,1,"POLD1, EXO1, LIG1, PMS2, POLD2, RPA3, RPA1, POLD3, RFC2, RFC5",0.863279432843593,0,FALSE
+"H1650","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.27644,0.801,0.791,7014,0.988,"PRKAA1, AKT2, RPS6KA1, MTOR, ULK2, DDIT4, MAPK3, PIK3R3, RICTOR, AKT3, CAB39, ULK1, TSC1, RPTOR, MLST8, RHEB, TSC2, PIK3CB, EIF4E, VEGFB, BRAF, VEGFC",0.101823516502323,0.00524305541237188,FALSE
+"H1650","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.34616,1.02,0.417,3669,1,"CHP1, IFNA5, RAET1E, HCST, ITGB2, RAET1G, RAET1L, FCGR3B, PPP3R1, MAP2K1, PPP3CA, VAV3, PLCG2, IFNB1, NFAT5, BID, RAC1, VAV1, NFATC1, PTK2B, ULBP2, NFATC3, VAV2, MAPK3, PIK3R3",0.379863945026242,0,FALSE
+"H1650","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.18027,0.518,0.99,5211,0.998,"GRIN3B, ADORA2A, ADRA2A, OPRK1, MLNR, THRB, CHRM4, P2RY2, P2RX2, S1PR5, TRPV1, LPAR2, ADRA1B, HTR1D, ADRA2B, S1PR1, P2RX5, OXTR, HTR6, PARD3, P2RX4, GABRE, PRLR, S1PR2, ADRB1, P2RY13, F2RL1, ADORA2B, GRIN2A, GALR2, VIPR1, GRM4, S1PR3, GABBR2, TBXA2R, GABRB3, PTAFR, GALR3, CHRNA4, P2RY6, NR3C1, GPR156, GLRB, C5AR1",0.00436480540245009,0.000869458712628891,FALSE
+"H1650","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31006,0.911,0.622,4851,0.959,"NTF4, CAMK2G, GAB1, MAP3K5, CALM3, YWHAZ, MAPK11, MAP2K1, PRKCD, PLCG2, RAP1A, YWHAB, NGF, ZNF274, AKT2, RAPGEF1, RPS6KA1, RAC1, TP73, CAMK2D, SH2B2, RPS6KA4, NFKBIB, ARHGDIB, MAPK13, RIPK2, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CALML6, CALM1, SH2B1, GRB2, RHOA",0.206209615309181,0.0181813928293364,FALSE
+"H1650","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.31926,-1.18,0.198,18057,0.671,"PNP, NAMPT, NMNAT3, NNT, NADSYN1",0.703334809738469,0.173277479831008,FALSE
+"H1650","Input","KEGG_NITROGEN_METABOLISM",-0.42922,-1.55,0.0435,15897,0.426,"CA7, HAL, CA3, CA14, AMT, CA8, GLUD2, CTH, CPS1, CA12, GLS2, CA13",1.36151074304536,0.370590400897281,FALSE
+"H1650","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34318,0.999,0.451,4230,0.995,"CCL5, MAPK11, IL6, NOD1, TAB3, PYCARD, TAB2, NFKBIB, IL18, MAPK13, RIPK2, MAPK3, CASP8, NLRC4, ERBIN, CARD8, CASP1",0.345823458122039,0.00217691925427455,FALSE
+"H1650","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.23973,0.694,0.91,5915,0.995,"XRCC4, XRCC6, NHEJ1, PRKDC",0.0409586076789064,0.00217691925427455,FALSE
+"H1650","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.33667,0.983,0.492,4157,0.957,"E2F1, MAP2K1, RASSF5, PLCG2, TGFA, AKT2, ERBB2, EGF, RXRA, EGFR, STK4, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1",0.30803489723264,0.0190880622231565,FALSE
+"H1650","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.36217,1.06,0.379,5177,1,"DTX4, PSENEN, KAT2B, DTX3L, NOTCH3, JAG2, DTX2, NUMBL, KAT2A, CTBP2, LFNG, EP300, HDAC1, DLL3, MAML2, HES5",0.421360790031928,0,FALSE
+"H1650","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.33265,0.968,0.487,4716,0.971,"ERCC4, POLE4, POLD1, RAD23A, GTF2H5, LIG1, POLE, ERCC2, ERCC1, RBX1, POLD2, RPA3, ERCC6, CETN2, RAD23B, RPA1",0.312471038785366,0.0127807700919951,FALSE
+"H1650","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.30488,0.893,0.63,5036,0.959,"MGAT5B, MAN1B1, B4GALT1, RPN2, MGAT3, DPM1, STT3A, B4GALT2, STT3B, ALG12, MAN2A1, RFT1, MGAT4A, MOGS, DOLPP1, MGAT1, MGAT2, DDOST",0.200659450546418,0.0181813928293364,FALSE
+"H1650","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.17232,-0.651,0.939,10204,1,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR6A2, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, ADCY3, OR5B3, OR10G3, OR10H1, OR1D2, OR52M1, OR2A7, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51E1, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR1N1, OR2C1, OR10G4, PDC, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR4D5, OR5K2, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, CAMK2B, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR51E2, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR11H6, OR52N4, OR10V1, CLCA4, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR51I1, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, ARRB2, OR8D2, OR2T33, OR1J2, OR2A5, OR52H1, CALM2, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, CALML3, OR4D1, OR8G1, OR4F15, OR52B6, OR2A25, GUCY2D, OR1Q1, OR8A1, CALML5, OR2B2, OR1K1, OR4F3, OR11H4, OR51B4, OR13A1, OR10AD1, OR6B2, OR2K2, OR13H1, OR7D2, OR2A14, OR13J1, OR4F16, OR4F17, OR2W3, PDE1C, OR56B4, OR1L8, OR2AE1, OR2H2, PRKX, OR52W1, GUCA1B, PRKG1, PRKG2",0.0273344077338891,0,FALSE
+"H1650","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.29854,0.862,0.706,6661,0.972,"MTHFD2, MTHFS, MTHFR, MTHFD1L, SHMT1, DHFR, ATIC, MTHFD2L",0.151195298948196,0.0123337350737254,FALSE
+"H1650","Input","KEGG_OOCYTE_MEIOSIS",0.39828,1.16,0.243,5310,1,"CHP1, CAMK2G, CALM3, YWHAZ, PLK1, PPP2R1A, PPP3R1, MAP2K1, PPP3CA, AURKA, YWHAB, PPP2R5E, CCNE1, PKMYT1, RPS6KA1, ANAPC2, SPDYA, CAMK2D, PRKACG, ADCY1, PPP1CB, ANAPC10, ADCY7, CDC23, SMC1B, SGO1, FBXO5, REC8, MAPK3, PRKACA, ITPR2, RBX1, ANAPC7, CCNB1, CALML6, CCNE2, CALM1, CDC20, ADCY6, YWHAE, BUB1, MAD2L2, PPP2CA",0.614393726401688,0,FALSE
+"H1650","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.23116,0.673,0.928,5738,0.987,"MANBA, NEU2, MAN2C1, HEXA, GLB1, FUCA2",0.0324520237811379,0.00568284733036327,FALSE
+"H1650","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.25352,0.736,0.879,5038,1,"NDUFAB1, UQCRC2, ATP6V0D1, ATP6V1C1, CYC1, UQCRFS1, LHPP, NDUFS6, NDUFB8, COX17, ATP6V0A1, COX6B1, ATP6V0C, COX15, UQCR10, NDUFA8, ATP6AP1, SDHA, NDUFB1, NDUFV2, ATP5MG, COX6C, SDHB, NDUFB3, NDUFB9, COX8A, NDUFB6, ATP6V1B1, NDUFB7, ATP6V0A4",0.0560111249262281,0,FALSE
+"H1650","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.46457,1.34,0.102,5221,1,"C1GALT1, GALNT7, GALNT3, B4GALT5, ST3GAL1, GALNT6, GALNT2, GALNT14, GALNT12, GALNT10, GCNT4, C1GALT1C1, GALNT9, GALNT13, GCNT1",0.991399828238082,0,FALSE
+"H1650","Input","KEGG_P53_SIGNALING_PATHWAY",0.36095,1.06,0.366,4216,1,"TP53AIP1, SIAH1, TP53I3, CYCS, EI24, CHEK2, BID, CCNE1, SFN, PERP, IGFBP3, GTSE1, SERPINB5, TP73, CCND3, CHEK1, SHISA5, PTEN, CASP8, RRM2, CDKN1A, CCNB1",0.436518914605589,0,FALSE
+"H1650","Input","KEGG_PANCREATIC_CANCER",0.35285,1.01,0.45,4020,1,"E2F1, STAT1, MAP2K1, TGFA, AKT2, STAT3, RAC1, SMAD2, TGFBR2, ERBB2, EGF, RAD51, RALA, EGFR, MAPK3, RALBP1, PIK3R3, AKT3, BCL2L1, BAD, RAF1, RALB",0.346787486224656,0,FALSE
+"H1650","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.19433,0.559,0.98,5637,1,"PPCS, UPB1, PANK4, DPYD, PPCDC",0.00877392430750515,0,FALSE
+"H1650","Input","KEGG_PARKINSONS_DISEASE",0.20965,0.613,0.97,4938,1,"NDUFAB1, UQCRC2, PINK1, UBE2G1, CYCS, CYC1, UQCRFS1, UBE2L6, TH, UBA7, NDUFS6, NDUFB8, COX6B1, UQCR10, NDUFA8, UBE2G2, SDHA, NDUFB1, NDUFV2, COX6C, SDHB, NDUFB3, NDUFB9, COX8A, NDUFB6, PARK7, NDUFB7",0.0132282657337552,0,FALSE
+"H1650","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.32728,0.955,0.523,6605,0.99,"CDH1, YWHAZ, ACTB, OCLN, TUBA4A, KRT18, CD14, ARPC3, TUBB8, ARPC5L, ITGB1, RHOA, TUBB6, EZR, ROCK1, CDC42, CLDN1, NCK2, YWHAQ, TUBA8, TUBB4B, TUBB3, TUBA1B",0.281498311132726,0.00436480540245009,FALSE
+"H1650","Input","KEGG_PATHWAYS_IN_CANCER",0.28172,0.821,0.745,5527,0.975,"CSF1R, TCF7L1, E2F1, CBLC, STAT1, CDH1, PDGFB, WNT9A, MAP2K1, CYCS, TFG, IL6, RASSF5, LAMA5, PLCG2, PTK2, FGFR2, EGLN3, ITGA6, EPAS1, GLI3, TGFA, BID, CCNE1, FGF11, FGF2, TRAF4, WNT7B, AKT2, PDGFA, STAT3, JUP, MTOR, RAC1, DAPK2, SMAD2, WNT7A, EGLN2, LAMA3, MITF, PPARG, TGFBR2, WNT6, ERBB2, CUL2, FZD6, TCF7L2, EGF, PTEN, RAD51, NFKB2, DAPK1, FZD9, CTNNA1, RALA, RXRA, EGFR, STK4, CTBP2, LAMB2, PIAS1, MAPK3, RALBP1, CASP8, PIK3R3, RUNX1, AKT3, LAMB1, BCL2L1, FZD2, LAMC2, BAD, RAF1, SKP2, RBX1, RALB, LAMB3, SOS1, CDKN1A, ITGAV, PLD1, EP300, BMP2, CCNE2, CCNA1, ITGA3, ITGB1, FZD1, GRB2, RHOA, HDAC1, LAMC1, MET, FOS, ELOC, PML, JAK1, KITLG, WNT9B, RALGDS, CDC42, FGF1, APPL1, MMP2, PLCG1",0.127843727251707,0.0109953843014632,FALSE
+"H1650","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.31844,0.925,0.574,4890,0.99,"UGT2B17, UGP2, RPEL1, RPE, DHDH, AKR1B1",0.241088107602027,0.00436480540245009,FALSE
+"H1650","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.36285,1.04,0.374,3657,1,"PGM1, PGLS, RPEL1, FBP2, GPI, RBKS, RPE, ALDOA, DERA",0.42712839779952,0,FALSE
+"H1650","Input","KEGG_PEROXISOME",0.31307,0.918,0.612,5734,0.979,"PXMP4, XDH, ACAA1, ECH1, SLC25A17, NUDT19, ACOX1, PEX10, PEX13, PRDX5, ACOT8, ACSL1, MPV17L, PEX3, MVK, DECR2, ACSL3, PEX14, SOD1, PRDX1, GSTK1, IDH2, ABCD1, IDH1, AGPS",0.213248577854439,0.00921730819686218,FALSE
+"H1650","Input","KEGG_PHENYLALANINE_METABOLISM",0.32357,0.923,0.591,5986,0.985,"ALDH3B2, GOT2, TAT, PRDX6, ALDH1A3, ALDH3B1, MIF, GOT1",0.228412519118745,0.00656376950238827,FALSE
+"H1650","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.34337,1,0.437,4869,1,"PLCD1, PLCE1, CALM3, CDS1, PLCG2, PIK3C2B, INPP4B, IMPA2, INPP5A, INPP1, ITPK1, DGKE, PIP4K2C, DGKA, INPP5E, PTEN, PIP5K1A, PIK3R3, SYNJ1, ITPR2, INPP4A, CALML6, INPPL1, PLCD3, IPPK, CALM1, PIK3C2G",0.359518563029578,0,FALSE
+"H1650","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.45732,1.32,0.11,3279,1,"EARS2, UGT2B17, BLVRB, HMOX2, FTH1, ALAS1, UROS, HMOX1, ALAS2, COX15",0.958607314841775,0,FALSE
+"H1650","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.2677,0.777,0.813,3351,0.988,"SLC27A6, SCD5, ANGPTL4, SLC27A4, ACAA1, ACOX1, PPARG, ACSL1, FABP5, RXRA",0.0899094544059319,0.00524305541237188,FALSE
+"H1650","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.37845,1.09,0.304,245,0.988,"CYP7B1",0.517126416391246,0.00524305541237188,FALSE
+"H1650","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.24562,-0.922,0.588,15016,0.909,"ZAP70, LCK, CD3D, IL2RG, CD19, RAG1, BTK, TNFRSF13C, IGLL1, CD4, DCLRE1C, JAK3, RFXAP",0.230622673923862,0.0414361167780325,FALSE
+"H1650","Input","KEGG_PRION_DISEASES",0.36312,1.07,0.351,3687,1,"CCL5, MAP2K1, IL6, HSPA1A, PRKACG, STIP1, MAPK3, PRKACA",0.454692883534176,0,FALSE
+"H1650","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.32122,0.94,0.571,5242,0.979,"PLK1, MAPK11, MAP2K1, AKT2, PKMYT1, RPS6KA1, ANAPC2, SPDYA, PRKACG, ADCY1, ANAPC10, MAPK13, ADCY7, CDC23, MAPK3, PIK3R3, PRKACA, AKT3, RAF1, ANAPC7, CCNB1, CDC25A, CDC25B, GNAI1, CCNA1, ADCY6, CCNA2, BUB1, MAD2L2",0.243363891754152,0.00921730819686218,FALSE
+"H1650","Input","KEGG_PROPANOATE_METABOLISM",-0.26429,-0.96,0.439,16336,0.906,"SUCLA2, LDHC, EHHADH, PCCB, ACADM, ALDH1B1, ALDH2, ACSS3, ALDH6A1, PCCA",0.357535479757879,0.0428718023231869,FALSE
+"H1650","Input","KEGG_PROSTATE_CANCER",0.289,0.839,0.717,4535,0.972,"TCF7L1, E2F1, PDGFB, MAP2K1, FGFR2, TGFA, CCNE1, AKT2, PDGFA, PDGFC, PDGFD, MTOR, ERBB2, TCF7L2, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CDKN1A, EP300, CCNE2",0.1444808443322,0.0123337350737254,FALSE
+"H1650","Input","KEGG_PROTEASOME",0.29886,0.876,0.685,6227,0.966,"PSMA2, PSMB10, PSMC4, PSMA7, PSMB6, PSMD11, PSMB3, PSMD8, PSMD12, PSMF1, PSMD7, PSMB1, PSMB11, PSMB2, PSMC3, PSMA6, PSMA4, PSMB9, PSMB7",0.164309428507574,0.0150228735845067,FALSE
+"H1650","Input","KEGG_PROTEIN_EXPORT",-0.33128,-1.19,0.188,17269,0.805,"SPCS2, SEC62, IMMP2L, OXA1L, SEC63",0.72584215073632,0.0942041196321315,FALSE
+"H1650","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.24015,0.694,0.905,2164,0.995,"GLS, MDH1, SLC25A10",0.0433514207947967,0.00217691925427455,FALSE
+"H1650","Input","KEGG_PURINE_METABOLISM",0.20608,0.601,0.965,6278,1,"POLR2K, XDH, GDA, POLR3H, PAPSS2, POLR2I, POLE4, POLR2C, POLD1, DGUOK, ADK, NME4, NUDT9, ENTPD6, POLR3K, ADCY1, PAPSS1, NPR1, NME3, POLE, ADCY7, ADA, AK2, PDE8A, PDE5A, POLA2, RRM2, POLR2A, POLD2, NME6, GUCY1B1, PDE6G, GUCY1A1, ADCY6, ENTPD2, POLR1A, GUCY1A2, AK4, AK1, POLR2F, NT5C3A, PDE9A, DCK, NT5C2, ENTPD5, ATIC, PNPT1, POLD3, PKM, PAICS",0.0154726866562074,0,FALSE
+"H1650","Input","KEGG_PYRIMIDINE_METABOLISM",0.35272,1.02,0.429,4082,1,"DHODH, POLR2K, CDA, POLR3H, POLR2I, POLE4, POLR2C, POLD1, DTYMK, CMPK2, TYMP, NME4, TK1, ENTPD6, POLR3K, UPP1, CTPS1, NME3, POLE, UPB1, UCKL1, DUT, POLA2, RRM2, POLR2A, TK2, POLD2, NME6",0.367542707815276,0,FALSE
+"H1650","Input","KEGG_PYRUVATE_METABOLISM",0.32653,0.943,0.546,6578,0.981,"PC, MDH1, LDHAL6B, ACSS2, GRHPR, ACSS1, MDH2, AKR1B1, ALDH3A2, PDHA1, ACAT2, ALDH9A1, PKM, ME3, PDHB",0.262807357295263,0.0083309926200515,FALSE
+"H1650","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.3528,1.03,0.428,5643,1,"PFN4, SSH2, ITGA4, PAK4, ARHGAP35, ITGB2, PDGFB, MYL9, CHRM4, MYH14, BCAR1, MAP2K1, ITGA1, VAV3, PTK2, FGFR2, ITGA6, ACTB, ARHGEF1, FGD3, PXN, FGF11, FGF2, PDGFA, PDGFC, ITGB8, PDGFD, TIAM1, SLC9A1, LIMK2, ACTN4, RAC1, BAIAP2, VAV1, RDX, PFN1, MYLK2, PIP4K2C, RRAS, PPP1CB, CD14, ARPC3, EGF, PIP5K1A, EGFR, CYFIP1, PAK6, VAV2, MAPK3, SSH3, PIK3R3, MYL5, ARPC5L, RAF1, BRK1, SOS1, TIAM2, ITGAV, MYL7, MRAS, GNA12, ITGA3, ITGB1, MYH9, MYL12B, ITGB4, SCIN, NCKAP1, RHOA, CFL2, EZR, PAK2, ROCK1, CDC42, ITGAE, FGF1, IQGAP1, CFL1, LIMK1, ACTN1",0.368556230986828,0,FALSE
+"H1650","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.45218,1.32,0.0937,3126,1,"IFNA5, GABARAPL2, ATG12, PRKAA1, ATG4B, ULK2, ATG7, ATG4D",1.02826040911222,0,FALSE
+"H1650","Input","KEGG_RENAL_CELL_CARCINOMA",0.40227,1.16,0.243,7564,1,"GAB1, PAK4, PDGFB, MAP2K1, EGLN3, RAP1A, EPAS1, TGFA, AKT2, RAPGEF1, RAC1, EGLN2, CUL2, PAK6, MAPK3, PIK3R3, AKT3, RAF1, RBX1, SOS1, EP300, GRB2, MET, PAK2, ELOC, CDC42, SLC2A1, HRAS, PIK3CB, TGFB3, VEGFB, BRAF, CRKL, VEGFC, SOS2, CRK, TGFB2, FLCN, CREBBP, ETS1, TGFB1",0.614393726401688,0,FALSE
+"H1650","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.4735,1.38,0.0795,1966,1,"ACE2, ANPEP, MME, CTSA",1.09963287134353,0,FALSE
+"H1650","Input","KEGG_RETINOL_METABOLISM",0.17876,0.516,0.992,1040,0.992,"DHRS9, UGT2B17, CYP26B1",0.00348832784582135,0.00348832784582135,FALSE
+"H1650","Input","KEGG_RIBOFLAVIN_METABOLISM",0.23988,0.689,0.914,4592,0.986,"MTMR2, ACP2, MTMR1, ACP1, PHPT1",0.0390538042661686,0.0061230850587888,FALSE
+"H1650","Input","KEGG_RIBOSOME",-0.68738,-2.46,0,16978,0.0188,"RPL34, RPL4, RPL35A, RPL19, RPL26, RPL39, RPS17, RPL17, RPL37A, RPS7, RPL18A, RPS4Y1, RPS3, RPS29, RPL9, RPL38, RPL7, RPL5, RPS3A, RPLP0, RPL22L1, RPL31, RPL23A, RPS27A, RPS23, RPL27, RPS8, RPS25, RPS4X, RPS27, RPL36A, RPS15, RPS18, RPL3, RPS28, RPS10, RPL10A, RPL21, RPL10, RPL36, RPLP2, RPS12, RPL27A, RPS13, RPL30",Inf,1.72584215073632,TRUE
+"H1650","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38733,1.12,0.295,4825,1,"IFNA5, DDX58, IRF3, IFIH1, TRADD, ISG15, MAPK11, ATG12, IFNB1, IL12A, CYLD, TANK, IL12B, NFKBIB, MAPK13, CASP8, AZI2, DHX58, TKFC, TRIM25, TBK1, TBKBP1",0.530177984021837,0,FALSE
+"H1650","Input","KEGG_RNA_DEGRADATION",0.37899,1.09,0.332,4271,0.988,"PARN, EXOSC6, LSM4, EDC4, DCPS, TENT4A, CNOT3, PATL1, CNOT1, EXOSC1, C1D, SKIV2L, EXOSC4, CNOT8, CNOT4, LSM5, LSM3, PAPOLB, EXOSC3, EXOSC5, EXOSC10",0.478861916295964,0.00524305541237188,FALSE
+"H1650","Input","KEGG_RNA_POLYMERASE",0.30447,0.889,0.643,1179,0.96,"POLR2K, POLR3H, POLR2I, POLR2C",0.191789027075778,0.0177287669604316,FALSE
+"H1650","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.32823,0.945,0.538,5641,0.997,"PAPSS2, PAPSS1, AHCYL2, AHCY, CBS, LCMT1, GGT1, GGT7, MAT2B, MAT2A",0.269217724333611,0.00130484168834428,FALSE
+"H1650","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.24963,0.732,0.876,4699,0.984,"E2F1, CYCS, LAMA5, PTK2, ITGA6, CCNE1, TRAF4, AKT2, LAMA3, PTEN, RXRA, LAMB2, PIAS1, PIK3R3, AKT3, LAMB1, BCL2L1, LAMC2, SKP2, LAMB3, ITGAV, CCNE2, ITGA3, ITGB1",0.0574958938319193,0.00700490156865849,FALSE
+"H1650","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.18256,0.528,0.99,3492,1,"STX11, YKT6, STX16, VAMP8, VTI1A",0.00436480540245009,0,FALSE
+"H1650","Input","KEGG_SPHINGOLIPID_METABOLISM",0.28335,0.825,0.742,4756,0.983,"SPTLC1, SMPD4, SPHK2, ARSA, DEGS1, GALC, NEU2, SMPD3, B4GALT6, SGMS2",0.129596094720973,0.00744648216786438,FALSE
+"H1650","Input","KEGG_SPLICEOSOME",0.29423,0.86,0.681,6805,0.96,"SF3B3, DHX38, HSPA2, CTNNBL1, PCBP1, LSM4, PRPF31, AQR, SRSF6, PUF60, TRA2A, SNRNP70, USP39, PHF5A, HSPA1A, U2AF2, SRSF9, SNRPA, HSPA1B, SNRPD3, PRPF40B, PRPF38A, SNRNP27, CHERP, U2SURP, LSM5, LSM3, SMNDC1, SNRPD2, TXNL4A, PPIE, BCAS2, SNRPG, PRPF4, ALYREF, SF3B4, BUD31, PRPF6, ZMAT2, DHX15, LSM6, SRSF4, PRPF38B, PLRG1, SNRPA1, RBM22, DDX46, DDX42, RBM25, HSPA6, HNRNPK, CWC15, PRPF8, SRSF8, SF3B5, PQBP1, WBP11",0.166852888087215,0.0177287669604316,FALSE
+"H1650","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.27188,0.799,0.788,6169,0.983,"UGT2B17, GYS1, UGP2, PGM1, AMY1A, GPI, HK2, HK1, AMY1B, UXS1, PYGL, PGM2, AGL",0.103473782510445,0.00744648216786438,FALSE
+"H1650","Input","KEGG_STEROID_BIOSYNTHESIS",0.24322,0.713,0.88,7038,0.99,"DHCR24, SQLE, MSMO1, SOAT1, SC5D, EBP, LIPA",0.0555173278498314,0.00436480540245009,FALSE
+"H1650","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.39955,1.16,0.241,1208,1,"SULT2B1, SULT1E1, CYP7B1, SRD5A1, UGT2B17, CYP1B1",0.617982957425132,0,FALSE
+"H1650","Input","KEGG_SULFUR_METABOLISM",0.72982,2.13,0.00107,4125,0.0607,"SULT2B1, SULT1E1, PAPSS2, SULT1A4, CHST12, PAPSS1, SULT1A3, CHST11, SULT1A2, SUOX",2.97061622231479,1.21681130892474,TRUE
+"H1650","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.16749,-0.598,0.964,14929,0.975,"FCGR2C, C7, GRIN2B, CD86, CTSG, C1S, C4B, ACTN2, C4A, FCGR2A, TNF, SNRPD1, C1R, C2",0.0159229660971692,0.0109953843014632,FALSE
+"H1650","Input","KEGG_TASTE_TRANSDUCTION",0.44181,1.3,0.119,4814,1,"KCNB1, TAS2R1, GNAS, GNG13, TAS2R43, TAS2R20, PRKACG, SCNN1G, TAS2R46, PRKACA, GRM4, TAS2R5, ASIC2, ADCY6",0.924453038607469,0,FALSE
+"H1650","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.42673,1.23,0.178,4965,1,"CSAD, GAD1, GGT1, GGT7",0.749579997691106,0,FALSE
+"H1650","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.29894,-1.1,0.213,17791,0.745,"IDI1, FDPS, PDSS2",0.671620396561262,0.127843727251707,FALSE
+"H1650","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.25714,0.749,0.848,5940,1,"BMP5, PPP2R1A, RBL2, E2F4, BMP7, SMAD2, NOG, ZFYVE16, TGFBR2, SMAD6, GDF6, ACVR2A, MAPK3, RBL1, ID1, RBX1, EP300, BMP2, AMH, SMAD1, RHOA, ID4, BMPR1A, ROCK1, PPP2CA, CUL1, ID3, THBS1, SMURF1",0.0716041477432862,0,FALSE
+"H1650","Input","KEGG_THYROID_CANCER",0.38796,1.14,0.253,3590,1,"TCF7L1, CDH1, MAP2K1, TFG, PPARG, TCF7L2, RXRA, MAPK3",0.596879478824182,0,FALSE
+"H1650","Input","KEGG_TIGHT_JUNCTION",0.43013,1.27,0.142,6038,1,"MYH15, SPTAN1, EPB41L1, MYL9, MYH14, PPP2R1A, SYMPK, CGN, PRKCD, ACTB, CSNK2A2, MYH3, TJP3, TJP1, AKT2, F11R, OCLN, ACTN4, AMOTL1, CLDN7, CLDN23, LLGL2, CLDN4, EXOC3, PARD3, RRAS, PARD6B, MAP3K20, AFDN, PTEN, CTNNA1, YBX3, TJP2, AKT3, PRKCI, CASK, MYL5, PRKCZ, PRKCE, PPP2R2D, MYL7, GNAI1, MRAS, CLDN9, MYH9, MYL12B, RHOA, VAPA, PATJ, PPP2R2C, MPDZ, CLDN8, PPP2CA, CDC42, CLDN1, ACTN1, PRKCH, MYH7B, MAGI1, HRAS",0.847711655616944,0,FALSE
+"H1650","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.40139,1.17,0.219,3889,1,"CCL5, TLR1, IFNA5, TLR6, STAT1, IRF3, MAPK11, MAP2K1, IL6, IFNB1, CD40, IL12A, AKT2, RAC1, MAP3K8, MYD88, TAB2, IL12B, CD14, MAPK13, TLR3, TIRAP, MAPK3, CASP8, PIK3R3, AKT3, TICAM2",0.659555885159882,0,FALSE
+"H1650","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.20627,-0.762,0.798,16293,0.916,"IDO1, AOC1, AFMID, EHHADH, MAOB, ALDH1B1, KYNU, ALDH2, TPH1, MAOA, WARS2",0.0979971086492706,0.0381045263321496,FALSE
+"H1650","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.19465,-0.699,0.885,15050,0.985,"CACNA1A, SLC2A4, PIK3CG, MAPK8, CACNA1B, PIK3R1, PIK3CD, CACNA1G, TNF, CACNA1C, GCK, IRS2, KCNJ11, IRS1, INSR, IKBKB",0.0530567293021746,0.00656376950238827,FALSE
+"H1650","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.21764,0.634,0.955,2786,1,"IL12A, IL12B, GAD1",0.0199966284162537,0,FALSE
+"H1650","Input","KEGG_TYROSINE_METABOLISM",-0.16285,-0.608,0.976,18363,1,"FAH, METTL2B, MAOA, GSTZ1",0.0105501823333082,0,FALSE
+"H1650","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31339,0.894,0.652,5345,0.966,"CHP1, PAK4, CBLC, PPP3R1, MAPK11, MAP2K1, PPP3CA, VAV3, NFAT5, MAP3K14, AKT2, MALT1, VAV1, MAP3K8, NFATC1, NFKBIB, MAPK13, PAK6, NFATC3, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1, PTPN6, GRB2, RHOA, FOS, PAK2, CDC42",0.18575240426808,0.0150228735845067,FALSE
+"H1650","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.41684,1.23,0.159,5940,1,"FBXO2, UBE2D4, SIAH1, FBXW7, UBR5, CBLC, WWP2, UBE2G1, HUWE1, ITCH, NEDD4L, UBE2E2, UBA2, UBE2L6, HERC3, SOCS1, ANAPC2, UBA7, SAE1, UBE2M, CUL2, UBE2E1, UBE2S, ANAPC10, CDC23, MID1, FANCL, WWP1, UBE4B, NHLRC1, PIAS1, HERC1, UBE2C, UBE2G2, UBE2D3, SKP2, RBX1, UBE3B, ANAPC7, UBE3A, NEDD4, KEAP1, FBXW8, UBE2K, CDC20, UBE2R2, UBE2Z, ELOC, PML, TRIP12, BIRC6, FBXO4, UBE2H, BRCA1, CUL1, BIRC2, UBE2B, SMURF1",0.798602875679548,0,FALSE
+"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.43174,1.25,0.145,6890,1,"PDHA1, PDHB, BCAT2, IARS2",0.838631997765025,0,FALSE
+"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.28153,0.824,0.743,7002,0.977,"ABAT, ACAA1, BCKDHA, HIBADH, ACAD8, MCEE, AOX1, ECHS1, HADHA, OXCT1, HMGCS1, MCCC2, ALDH3A2, ACAT2, HSD17B10, HADHB, ALDH9A1, ACAA2, BCAT2, MCCC1, OXCT2",0.129011186239425,0.0101054362812269,FALSE
+"H1650","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.31606,0.917,0.597,4851,0.962,"ADORA2A, CALM3, MYL9, GNAS, CACNA1D, MAP2K1, PRKCD, PLA2G12A, ARHGEF1, KCNMB4, ADRA1B, PLA2G4B, GNAQ, PRKACG, ADCY1, MYLK2, NPR1, PPP1CB, ADCY7, KCNMA1, MAPK3, ADORA2B, PRKACA, KCNMB3, ITPR2, RAF1, GUCY1B1, PRKCE, CALML6, GUCY1A1, GNA12, CALM1, ADCY6, RHOA",0.224025668870631,0.0168249279621871,FALSE
+"H1650","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33906,0.989,0.47,6295,0.963,"DYNC1LI2, GNAS, DCTN1, DCTN5, DYNLL2, PRKACG, ARHGDIB, RAB11A, PRKACA, DYNC1H1, AQP3, RAB5C, ADCY6, CREB3, RAB5A, DYNLL1, STX4, PRKACB, CREB3L1",0.327902142064283,0.0163737128754655,FALSE
+"H1650","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.41642,1.21,0.181,3976,1,"CHP1, HSPB1, PPP3R1, MAPK11, MAP2K1, PPP3CA, PLCG2, PTK2, PLA2G12A, NFAT5, PXN, AKT2, PLA2G4B, SPHK2, MAPKAPK3, RAC1, NFATC1, MAPK13, NFATC3, MAPK3, PIK3R3, AKT3, BAD, RAF1",0.742321425130815,0,FALSE
+"H1650","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.42622,1.23,0.178,5632,1,"ATP6V0D1, ERO1A, GNAS, ATP6V1C1, PLCG2, ACTB, TJP1, KDELR1, PRKACG, ATP6V0A1, ATP6V0C, PRKACA, TJP2, ATP6AP1, KDELR2, SEC61G, ARF1, ATP6V1B1, ATP6V0A4, PLCG1, ATP6V1E1, SEC61A2",0.749579997691106,0,FALSE
+"H1650","Input","KEGG_VIRAL_MYOCARDITIS",0.50373,1.47,0.0502,2152,1,"MYH15, DAG1, ITGB2, MYH14, CYCS, ACTB, CD40, MYH3, BID, EIF4G1, CXADR, RAC1",1.29929628285498,0,FALSE
+"H1650","Input","KEGG_WNT_SIGNALING_PATHWAY",0.2983,0.867,0.687,4006,0.969,"CHP1, TCF7L1, CAMK2G, SIAH1, WNT9A, PPP2R1A, PPP3R1, PPP3CA, NFAT5, CSNK2A2, PPP2R5E, CTNNBIP1, WNT7B, RAC1, SMAD2, WNT7A, NFATC1, WNT6, CAMK2D, VANGL2, PRKACG, CCND3, FZD6, TCF7L2, FZD9, CTBP2, NFATC3, DAAM1, PRKACA, LRP5, FZD2, RBX1",0.16304326294045,0.0136762229492347,FALSE
+"HCC95","Input","KEGG_ABC_TRANSPORTERS",0.30702,1.02,0.399,1853,0.813,"ABCG1, ABCC1, ABCA4, ABCB6, ABCA13, TAP2, ABCC5",0.399027104313252,0.0899094544059319,FALSE
+"HCC95","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.30346,0.993,0.45,4099,0.819,"EIF4EBP1, IKBKB, GRB2, BAD, PIK3CA, JUP, PIK3R2, CEBPA, MYC, LEF1, BRAF, PIK3CB, CCNA1, KRAS, PML, HRAS, MAPK1, PIM1, RUNX1, AKT2",0.346787486224656,0.0867160982395816,FALSE
+"HCC95","Input","KEGG_ADHERENS_JUNCTION",0.27962,0.913,0.556,5098,0.863,"NECTIN1, RAC3, YES1, NLK, PTPN6, EGFR, SNAI2, LEF1, CDH1, CSNK2A2, MET, MAP3K7, IGF1R, WASF3, PTPRB, CSNK2A1, TJP1, MAPK1, SRC, PTPN1, SMAD2, TGFBR1, BAIAP2, RAC1, ERBB2",0.254925208417942,0.0639892042847904,FALSE
+"HCC95","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.44892,1.47,0.0673,4121,0.508,"ADIPOR1, ACSL6, ADIPOR2, POMC, IKBKB, CAMKK1, RXRA, IRS1, CPT1A, MAPK9, MAPK10, ACSL3, SLC2A4, NFKBIB, PRKAA1, PRKCQ, SLC2A1, ACACB, PRKAG2, MAPK8, TRADD, AKT2, CAMKK2",1.17198493577602,0.294136287716081,FALSE
+"HCC95","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.49111,1.61,0.0408,3522,0.475,"GLS2, GLUL, GOT2, ASNS, ALDH4A1, CAD, ASS1, GOT1, ALDH5A1, GPT2, GAD1",1.38933983691012,0.323306390375133,FALSE
+"HCC95","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.29786,0.976,0.455,3156,0.821,"ATP1B3, SFN, SCNN1A, PIK3CA, PIK3R2, IRS1, ATP1A1, PIK3CB, KRAS",0.341988603342888,0.0856568428805592,FALSE
+"HCC95","Input","KEGG_ALLOGRAFT_REJECTION",0.21337,0.697,0.882,15037,1,"CD40, CD86, IL12A, FAS, IFNG, CD40LG, IL2, CD28, FASLG, IL12B, GZMB, CD80, IL4, PRF1, IL10, TNF, IL5",0.0545314148681803,0,FALSE
+"HCC95","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.33598,1.1,0.314,2278,0.707,"FADS2, PLA2G4B, PLA2G4A, PLA2G12A",0.503070351926785,0.150580586203101,FALSE
+"HCC95","Input","KEGG_ALZHEIMERS_DISEASE",0.2159,0.708,0.871,4348,1,"CALML3, NDUFB5, NDUFB7, PPP3R2, NOS1, SNCA, GAPDH, NDUFS6, BAD, ATP5MC1, ATP5PD, PLCB1, NDUFA9, COX5A, ITPR3, NDUFV2, ATP2A3, NDUFB10, CAPN1, NAE1, NDUFA4L2, IL1B, BID, UQCRFS1, ADAM17, SDHD, NDUFA2, ATP2A2, SDHA, MAPK1, NDUFS4, NDUFA8, CDK5, PLCB3, CACNA1D, COX7C",0.0599818449923368,0,FALSE
+"HCC95","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.39923,-1.46,0.092,16276,0.358,"PARS2, LARS2, TARS2, FARSA, PSTK, CARS2, YARS2, FARS2",1.03621217265444,0.446116973356126,FALSE
+"HCC95","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.33085,-1.21,0.186,16584,0.49,"FPGT, HK2, RENBP, GNE, GMDS, GALE, GMPPA, GALT, PGM1, PMM1, UAP1, NAGK",0.730487055782084,0.309803919971486,FALSE
+"HCC95","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.37768,1.22,0.186,2891,0.588,"CAT, NEFL, PPP3R2, CASP1, NOS1, BCL2, NEFM, BAD, MAPK13, DAXX, MAPK12, MAP2K6, BID",0.730487055782084,0.230622673923862,FALSE
+"HCC95","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26382,0.873,0.607,4226,0.886,"CANX, HSP90AB1, HSPA1B, RFXANK, PSME3, TAP2, RFXAP, IFI30, CD8A, KIR2DL3, TAP1, TAPBP, HSPA4, PDIA3",0.216811308924742,0.0525662781129492,FALSE
+"HCC95","Input","KEGG_APOPTOSIS",0.23221,0.754,0.811,3028,0.982,"IL1A, IL1RAP, PPP3R2, IKBKB, BCL2, NGF, BAD, PIK3CA, PIK3R2, PRKACA, ENDOD1, ENDOG, CAPN1, TNFSF10, IL1B, BID, PIK3CB",0.090979145788844,0.00788851221305034,FALSE
+"HCC95","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.46762,1.53,0.0536,2278,0.496,"CYP4F3, AKR1C3, GPX2, ALOX12B, PTGES2, GPX3, CBR1, EPHX2, CBR3, PLA2G4B, LTC4S, TBXAS1, PLA2G4A, PLA2G12A",1.27083521030723,0.304518323509803,FALSE
+"HCC95","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.41436,1.36,0.123,3357,0.496,"GLS2, PYCR2, GLUL, CKMT1B, CKMT1A, NOS1, GOT2, PYCR1, ALDH3A2, ALDH4A1, ASS1, NOS2, GOT1, GAMT, GATM, PYCR3, OAT, CKB, ALDH2",0.910094888560602,0.304518323509803,FALSE
+"HCC95","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.18401,0.599,0.976,3704,0.994,"CACNA2D3, CACNG4, JUP, ITGB4, PKP2, ITGA2, LEF1, CACNB1, DSG2, ITGA6, ITGA2B, CDH2, SLC8A1, ATP2A2, GJA1",0.0105501823333082,0.00261361560268669,FALSE
+"HCC95","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.43946,-1.58,0.0556,18925,0.456,"ALDH9A1, ALDH7A1",1.25492520841794,0.341035157335565,FALSE
+"HCC95","Input","KEGG_ASTHMA",0.23332,0.762,0.807,622,1,"EPX",0.0931264652779296,0,FALSE
+"HCC95","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.23195,-0.84,0.656,8962,0.959,"IFNA4, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, CD28, FASLG, TPO, GZMB, TSHB, CD80, IFNA13, IL4, CTLA4, PRF1, IL10, IFNA21, CGA, IFNA1, IFNA5, TSHR, IL5",0.18309616062434,0.0181813928293364,FALSE
+"HCC95","Input","KEGG_AXON_GUIDANCE",0.22644,0.742,0.812,3156,0.986,"PAK2, SEMA4D, RAC3, PPP3R2, EFNB1, SEMA4A, SEMA3F, NTN1, EFNB3, EPHA1, DPYSL5, EPHB4, SEMA4F, PAK6, NCK1, UNC5B, GNAI1, NFATC1, PAK1, ABLIM1, EPHA8, EPHB3, RHOD, EPHB6, MET, SEMA4B, KRAS",0.0904439707588247,0.0061230850587888,FALSE
+"HCC95","Input","KEGG_BASAL_CELL_CARCINOMA",0.55164,1.79,0.0188,2279,0.317,"WNT3A, FZD1, WNT5A, WNT8B, GLI2, FZD10, DVL3, WNT10A, SMO, WNT7B, WNT11, WNT10B, FZD9, WNT9A, AXIN1, PTCH1, WNT7A, WNT16, WNT4, LEF1",1.72584215073632,0.498940737782249,FALSE
+"HCC95","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.39984,1.31,0.135,5303,0.511,"STON1, TAF6, TAF11, GTF2H4, GTF2F2, TAF4B, GTF2IRD1, GTF2H3, TAF7, TAF5L, TAF6L, GTF2A2, TAF4, TAF9B, GTF2I, TAF1, GTF2H2, GTF2A1L, TAF5",0.869666231504994,0.291579099865287,FALSE
+"HCC95","Input","KEGG_BASE_EXCISION_REPAIR",0.37934,1.25,0.18,2468,0.574,"POLB, UNG, PCNA, FEN1, POLE2, POLD2, POLE3, PARP1, HMGB1, NTHL1",0.744727494896694,0.241088107602027,FALSE
+"HCC95","Input","KEGG_BETA_ALANINE_METABOLISM",-0.34586,-1.25,0.185,17649,0.506,"DPYD, ACADM, ALDH9A1, SMS, ALDH7A1",0.732828271596986,0.295849483160201,FALSE
+"HCC95","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.36381,1.19,0.213,2850,0.633,"TECR, SCD, FADS2, FADS1, HADHA, ELOVL5, SCD5",0.671620396561262,0.198596289982645,FALSE
+"HCC95","Input","KEGG_BLADDER_CANCER",-0.25625,-0.939,0.475,16469,0.926,"MDM2, MMP1, RAF1, DAPK3, TYMP, DAPK1, CDKN2A, RASSF1, ARAF",0.323306390375133,0.0333890133180656,FALSE
+"HCC95","Input","KEGG_BUTANOATE_METABOLISM",0.33926,1.08,0.299,3522,0.723,"AKR1B10, HMGCS1, EHHADH, ALDH3A2, BDH1, L2HGDH, HADHA, ACAT2, ALDH5A1, OXCT1, ALDH2, GAD1",0.52432881167557,0.140861702705469,FALSE
+"HCC95","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.25356,0.849,0.657,3328,0.897,"SYK, RAC3, PPP3R2, IKBKB, PTPN6, GRB2, PIK3CA, PIK3R2, LYN, NFATC1, IFITM1, MALT1, NFKBIB, PIK3CB, KRAS, FOS, HRAS",0.182434630440219,0.0472075569559079,FALSE
+"HCC95","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.23852,0.792,0.77,2808,0.968,"CALML3, VDAC3, ADCY3, PPP3R2, NOS1, CHRNA7, VDAC2, ADRA1A, EGFR, PLCB1, PHKB, ADORA2B, ADCY1, GNAL, CAMK4, GNA15, PRKACA, PTAFR, ADRB2, ATP2B4, ITPR3, ATP2A3, CHRM3, PLCD1, TACR1, NOS2, HTR2C",0.113509274827518,0.0141246426916063,FALSE
+"HCC95","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.19759,0.65,0.932,5223,0.995,"TNNI3, CACNA2D3, ATP1B3, CACNG4, COX5A, ATP1A1, CACNB1, UQCRFS1, SLC8A1, ATP2A2, CACNA1D, COX7C, MYL2, TPM4, COX5B, CYC1, UQCRHL, UQCRC1, COX8A",0.0305840876460186,0.00217691925427455,FALSE
+"HCC95","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.18793,0.621,0.963,3590,0.996,"CLDN8, CLDN11, NECTIN1, CNTN1, SDC1, CDH3, CNTNAP2, JAM3, CLDN4, CLDN7, CDH1, ITGA6, CLDN1, F11R, CD8A, ICOSLG, CDH2, NEO1, CD40",0.0163737128754655,0.00174066157630127,FALSE
+"HCC95","Input","KEGG_CELL_CYCLE",0.33735,1.1,0.298,5745,0.707,"YWHAG, MCM7, ANAPC1, CCNB2, SFN, MCM3, CDC6, SKP2, E2F4, TFDP1, ORC3, MCM4, ANAPC11, PCNA, GADD45G, ORC5, MYC, RB1, CDC23, CCND2, CCND3, CDC45, CUL1, RBL1, BUB1, CDC26, TFDP2, CCNA1, PKMYT1, BUB1B, DBF4, CDC14B, CDC25C, STAG1, CCNA2, TGFB2, CHEK1, PTTG1, MAD2L2, ANAPC7, HDAC1, CDC27, SMAD2, CDKN1B, ATR, PTTG2, CCND1, PRKDC, SKP1, CCNB1, TTK, CREBBP, E2F2, PLK1, BUB3, MAD2L1, ANAPC4, MCM6",0.525783735923745,0.150580586203101,FALSE
+"HCC95","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.23257,0.76,0.789,3156,1,"GRK7, CXCR2, ADCY3, GRK6, ELMO1, IKBKB, GRB2, GNB2, GNG4, CCL19, CX3CL1, XCL2, PIK3CA, PIK3R2, PLCB1, ADCY1, CCL26, LYN, PRKACA, GNAI1, PAK1, GNB4, NFKBIB, CXCL14, BRAF, GNB5, CXCL16, ARRB2, PIK3CB, KRAS",0.10292299679058,0,FALSE
+"HCC95","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.20635,0.677,0.914,4942,1,"IKBKB, GRB2, BAD, PIK3CA, PIK3R2, MYC, RB1, BCR, BRAF, CBLC, PIK3CB, KRAS, HRAS, CRKL, TGFB2, MAPK1, RUNX1, AKT2, HDAC1, MECOM, CDKN1B, TGFBR1, SHC1, CCND1",0.0390538042661686,0,FALSE
+"HCC95","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.57348,-2.18,0,15139,0.149,"BHLHE41, CRY1, PER1, NR1D1, NPAS2, CLOCK, CRY2",Inf,0.826813731587726,TRUE
+"HCC95","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.35315,-1.23,0.196,17455,0.512,"ACO2, SDHC, PDHB, ACO1, SUCLG1, IDH3G, SUCLG2, PDHA1",0.707743928643524,0.290730039024169,FALSE
+"HCC95","Input","KEGG_COLORECTAL_CANCER",0.28377,0.949,0.497,5155,0.83,"RAC3, BCL2, BAD, PIK3CA, PIK3R2, MSH6, AXIN1, MAPK9, MYC, MAPK10, LEF1, BRAF, PIK3CB, KRAS, FOS, TGFB2, BIRC5, MAPK1, MAPK8, AKT2, SMAD2, TGFBR1, CCND1, RAC1, MSH2",0.303643611266668,0.0809219076239261,FALSE
+"HCC95","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.1956,-0.702,0.882,11767,1,"C9, C5AR1, C2, SERPINF2, FGB, F2, MASP1, C4BPA, F13A1, CFI, SERPINC1, F7, A2M, FGG, C7, SERPIND1, F10, F5, C3, PLG, CD55, MASP2, SERPINA5, C3AR1, C4BPB, SERPINA1, KLKB1, CD59, PLAUR, SERPING1, F2R, THBD, C4A, C8G, PROS1, C4B, CFB, TFPI",0.0545314148681803,0,FALSE
+"HCC95","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.43542,1.44,0.0782,1547,0.499,"APIP, LDHC, GOT2, MAT2B, AHCY, ENOPH1",1.10679324694015,0.30189945437661,FALSE
+"HCC95","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.12362,0.41,1,3613,1,"CXCR2, BMP7, FLT4, IL1A, IL1RAP, NGFR, PDGFA, EDAR, CCL19, CX3CL1, EGFR, XCL2, CCL26, IFNLR1, LTB, IL17RA, IL22RA1, TNFSF10, CXCL14, LTBR, IL1B, CXCL16, MET, TNFRSF21, PDGFB, TNFSF18, IL20RB, TNFSF15, IL10RB, CD40, TGFB2",0,0,FALSE
+"HCC95","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.18491,-0.677,0.886,18304,1,"TBK1, DDX58, POLR3C, RIPK1",0.0525662781129492,0,FALSE
+"HCC95","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.18254,-0.662,0.944,14293,0.981,"TNF, IGF1, ADCY5, CACNG7, SGCD, LAMA2, LMNA, SGCA, TNNC1, CACNB2, DES, RYR2, ITGA9, CACNA2D1, ADCY4, ITGA10, ITGB7, ITGB5, CACNA1C, DMD, CACNA2D4, CACNG6, PRKACB, CACNG8, ITGA7, ITGA1, ITGB3, ITGB1, ADCY6, ACTB, TGFB3, TPM2",0.025028005701931,0.0083309926200515,FALSE
+"HCC95","Input","KEGG_DNA_REPLICATION",0.61576,2.06,0.00414,4130,0.479,"RFC4, MCM7, MCM3, RFC2, MCM4, PCNA, RNASEH2B, FEN1, POLE2, POLD2, POLE3, RFC3, RPA3, PRIM1, SSBP1, RPA1, POLA2, RFC5, RNASEH2C, DNA2, PRIM2",2.3829996588791,0.319664486585437,FALSE
+"HCC95","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.24456,0.811,0.705,3940,0.936,"GRB2, ETV7, EGFR, KRAS, SPIRE2, MAPK1, NOTCH1",0.151810883008601,0.0287241512618947,FALSE
+"HCC95","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.32068,1.05,0.357,2955,0.767,"ADH7, ALDH3A1, UGT2B17, GSTM3, GSTP1, ADH5, GSTA4, GSTA1",0.447331783887807,0.115204636051019,FALSE
+"HCC95","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.34161,1.11,0.285,1986,0.744,"GMPS, TPMT, IMPDH1, TK1, UGT2B17, HPRT1, CES1",0.54515513999149,0.128427064454121,FALSE
+"HCC95","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.25009,0.822,0.706,3315,0.929,"LAMA1, VWF, CD44, COL4A6, SDC1, ITGB4, LAMC2, ITGA2, SPP1, LAMB3, SV2A, ITGA6, ITGA2B, THBS4, GP1BA, LAMA3",0.151195298948196,0.0319842860063582,FALSE
+"HCC95","Input","KEGG_ENDOCYTOSIS",0.25311,0.828,0.689,3027,0.925,"GRK7, TRAF6, CXCR2, FGFR2, GRK6, ACAP2, PRKCI, RAB4A, EPN3, AP2M1, FGFR3, TFRC, MVB12A, GIT1, HSPA1B, SNF8, CHMP6, VPS4B, EGFR, AP2B1, SH3GL3, PIP4K2B, ADRB2, RAB5C, CLTCL1, PLD1, RAB31, RUFY1, RAB11FIP1, ITCH, CHMP1B, CBLC, ARAP3, MET, ARRB2, VPS25",0.161780778092374,0.0338582672609674,FALSE
+"HCC95","Input","KEGG_ENDOMETRIAL_CANCER",-0.25355,-0.936,0.549,16363,0.896,"PIK3R3, PIK3R1, SOS1, RAF1, AXIN2, TCF7, TCF7L2, ILK, SOS2, GSK3B, ELK1, ARAF",0.260427655549908,0.0476919903378748,FALSE
+"HCC95","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.3968,1.32,0.13,5491,0.504,"CXCR2, ATP6V1C2, PTPRZ1, ATP6V1E2, GIT1, IKBKB, EGFR, JAM3, MAPK13, LYN, MAPK9, PAK1, MAPK10, MAPK12, MET, F11R, ADAM17, HBEGF, ATP6V0A2, TJP1, MAPK8, ATP6V1G2, SRC, MAPK14, MAPK11, ATP6V0C, ATP6V0E2, RAC1, PLCG2, ATP6AP1, CSK, MAP3K14, IKBKG, ADAM10",0.886056647693163,0.297569463554475,FALSE
+"HCC95","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.29124,0.962,0.478,4125,0.836,"NRG1, PAK2, NRG4, EIF4EBP1, GRB2, EGFR, BAD, PIK3CA, PIK3R2, PAK6, NCK1, MAPK9, MYC, PAK1, MAPK10, BRAF, CBLC, PIK3CB, KRAS, HBEGF, HRAS, CRKL, NCK2, MAPK1, MAPK8, PAK4, SRC, AKT2, CAMK2G",0.320572103387881,0.0777937225609836,FALSE
+"HCC95","Input","KEGG_ETHER_LIPID_METABOLISM",0.30781,0.992,0.419,3292,0.81,"PLA2G4B, PLD1, PLA2G4A, PLA2G12A, PLPP1, PLPP2, PAFAH1B2, LPCAT2",0.377785977033705,0.0915149811213502,FALSE
+"HCC95","Input","KEGG_FATTY_ACID_METABOLISM",0.35809,1.17,0.24,3440,0.656,"ADH7, ACSL6, EHHADH, ALDH3A2, ECI1, CPT1A, ACSL3, HADHA, ADH5, ACAT2, ALDH2, HADHB",0.619788758288394,0.18309616062434,FALSE
+"HCC95","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.26261,0.862,0.632,4493,0.894,"SYK, RAC3, GRB2, PIK3CA, PIK3R2, PLA2G4B, MAPK13, LYN, MAPK9, PLA2G4A, MAPK10, PLA2G12A, MAPK12, MAP2K6, PIK3CB, KRAS, HRAS, MAPK1, MAPK8, AKT2, MAPK14, MAPK11, VAV2",0.199282921717615,0.0486624812040823,FALSE
+"HCC95","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.24326,-0.875,0.593,15255,0.96,"PLCG1, PLPP3, PLA2G4F, AMPH, INPP5D, PIP5K1B, FCGR1A, FCGR2A, PIK3R3, PIK3R1, ARPC3, ARPC4, RAF1, DOCK2, PIP5K1C, PLA2G6, ARF6, CDC42, LAT, PRKCA, ASAP2, CFL2, DNM2, GAB2, PIP5K1A, VASP, DNM1L, MARCKSL1",0.226945306635737,0.0177287669604316,FALSE
+"HCC95","Input","KEGG_FOCAL_ADHESION",0.22127,0.726,0.852,4105,0.995,"PDGFD, LAMA1, VWF, PAK2, FLT4, RAC3, COL4A6, CAV1, PDGFA, BCL2, GRB2, CAV2, EGFR, BAD, PIK3CA, PIK3R2, ITGB4, LAMC2, ITGA2, DIAPH1, PAK6, MAPK9, SPP1, LAMB3, PAK1, MAPK10, CCND2, CCND3, BRAF, ITGA6, ITGA2B, MET, PIK3CB, THBS4, PDGFB, MYL12B, LAMA3, HRAS, IGF1R, PPP1CB, CRKL, LAMA5, MAPK1, MAPK8, PAK4, TNC, SRC, AKT2, COL4A1",0.0695604052332999,0.00217691925427455,FALSE
+"HCC95","Input","KEGG_FOLATE_BIOSYNTHESIS",0.35829,1.18,0.223,4694,0.645,"DHFR, SPR, GGH",0.651695136951839,0.190440285364732,FALSE
+"HCC95","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.36988,1.21,0.188,5217,0.599,"AKR1B10, ALDOC, TPI1, SORD, KHK, MPI, AKR1B1, MTMR1, PFKM, HK1, PFKFB2, MTMR2, ALDOA, FBP2",0.72584215073632,0.222573177610689,FALSE
+"HCC95","Input","KEGG_GALACTOSE_METABOLISM",0.26782,0.876,0.626,4310,0.888,"GLA, B4GALT2, GANC, AKR1B1, GAA, GCK, PFKM, GALK2, HK1",0.20342566678957,0.051587034221399,FALSE
+"HCC95","Input","KEGG_GAP_JUNCTION",0.25971,0.855,0.641,4826,0.892,"PDGFD, ADCY3, PDGFA, GRB2, EGFR, PLCB1, ADCY1, PRKACA, GNAI1, ITPR3, HTR2C, LPAR1, TUBAL3, KRAS, PDGFB, HRAS, TUBA4A, MAP2K5, GJA1, TJP1, MAPK1, SRC, PLCB3, TUBB, PDGFC, GUCY1B1, ADCY9",0.193141970481183,0.0496351456238769,FALSE
+"HCC95","Input","KEGG_GLIOMA",0.22471,0.736,0.855,4125,0.988,"CALML3, PDGFA, GRB2, EGFR, PIK3CA, PIK3R2, RB1, BRAF, PIK3CB, KRAS, PDGFB, HRAS, IGF1R, MAPK1, AKT2, CAMK2G",0.0680338852718274,0.00524305541237188,FALSE
+"HCC95","Input","KEGG_GLUTATHIONE_METABOLISM",0.44028,1.43,0.0848,1394,0.499,"GCLC, GCLM, PGD, GPX2, GSR, G6PD, GPX3, GGCT, GSTM3",1.07160414774329,0.30189945437661,FALSE
+"HCC95","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.24477,-0.87,0.575,18025,0.94,"AGPAT4, LIPG, GK, MGLL, ALDH9A1, ALDH7A1",0.24033215531037,0.0268721464003014,FALSE
+"HCC95","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.41499,1.33,0.134,3494,0.526,"LPCAT3, DGKH, LCLAT1, PTDSS1, PCYT1A, GNPAT, PCYT2, PCYT1B, PLA2G4B, DGKE, PLD1, PLA2G4A, PLA2G12A, ETNK2, PEMT, PLPP1, CDS1, ETNK1, CDIPT, PLPP2, PGS1, CDS2, AGPAT3, LPCAT2, GPD2, DGKA",0.872895201635192,0.279014255846261,FALSE
+"HCC95","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.42973,1.4,0.085,3249,0.483,"GNMT, AOC2, PIPOX, PSAT1, SHMT1, AOC3, GAMT, GATM, PHGDH, GCAT",1.07058107428571,0.316052869248488,FALSE
+"HCC95","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.39925,1.33,0.107,4582,0.526,"ADH7, LDHC, ALDH3A1, ALDOC, TPI1, GAPDH, ACSS1, GPI, ALDH3A2, BPGM, ACSS2, ADH5, DLAT, PGAM4, ALDH2, LDHB, ALDH1A3, PGAM1, GCK, PFKM, HK1, PKM, PCK2",0.97061622231479,0.279014255846261,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36743,1.22,0.211,5286,0.588,"B4GALT7, XYLT2, CHST14, CHST7, CHST15, B3GAT3, CHPF, CHSY1, CHST3, CHST12, B3GALT6",0.675717544702307,0.230622673923862,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.47807,1.56,0.0393,3874,0.503,"HS6ST1, B4GALT7, XYLT2, HS6ST2, HS3ST3B1, GLCE, NDST2, B3GAT3, NDST1, HS3ST3A1",1.40560744962457,0.298432014944073,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.56397,-2,0.0115,14254,0.193,"ST3GAL3, CHST4, CHST2, CHST6, B3GNT7, FUT8, B4GALT4, B4GALT3, ST3GAL1",1.93930215964639,0.714442690992226,TRUE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.38633,1.26,0.166,2073,0.564,"HPSE, HGSNAT, HS3ST3B1, HEXB, NAGLU",0.779891911959945,0.248720896016658,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.44391,1.48,0.0688,2469,0.515,"SLC33A1, B4GALNT1, B3GALT4, HEXB, ST6GALNAC4",1.16241156176449,0.288192770958809,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.2793,0.913,0.579,1845,0.863,"GLA, FUT1, HEXB",0.237321436272564,0.0639892042847904,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.33183,-1.22,0.184,14254,0.5,"ST3GAL3, B3GALT2, FUT7, FUT9, FUT3, FUT4, B3GALT1, B3GALT5, ST3GAL6, B3GNT3, B4GALT4, B4GALT3",0.735182176990464,0.301029995663981,FALSE
+"HCC95","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.56763,1.87,0.0119,788,0.367,"PIGX, PIGS, PIGW, PIGU, PIGV, PIGN",1.92445303860747,0.435333935747911,FALSE
+"HCC95","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.32728,-1.2,0.192,17087,0.483,"GLYCTK, ACO2, ACO1, MTHFD2L, HYI",0.71669877129645,0.316052869248488,FALSE
+"HCC95","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28819,0.938,0.522,4347,0.848,"CALML3, ADCY3, GRB2, EGFR, PLA2G4B, MAPK13, PLCB1, ADCY1, MAPK9, PRKACA, PLD1, ITPR3, PLA2G4A, MAPK10, PLA2G12A, MAPK12, MAP2K6, KRAS, HBEGF, HRAS, MMP14, MAPK1, MAPK8, SRC, CAMK2G, PLCB3, MAPK14, CACNA1D, ATF4, MAPK11",0.282329496997738,0.0716041477432862,FALSE
+"HCC95","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.32068,1.06,0.345,4253,0.753,"IL1A, IL1B, KIR2DL3, CD86",0.462180904926726,0.123205023799299,FALSE
+"HCC95","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.55523,1.82,0.024,2277,0.382,"WNT3A, BMP7, WNT5A, WNT8B, GLI2, WNT10A, SMO, WNT7B, WNT11, FBXW11, WNT10B, WNT9A, PTCH1, WNT7A, WNT16, PRKACA, WNT4, CSNK1A1",1.61978875828839,0.417936637088291,FALSE
+"HCC95","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.19165,0.63,0.961,3166,0.996,"CD44, IL1A, CD1D, TFRC, CD9, ITGA2, ITGA6, IL1B, CD1E, ITGA2B, CD8A, GP1BA",0.0172766123314547,0.00174066157630127,FALSE
+"HCC95","Input","KEGG_HISTIDINE_METABOLISM",0.2761,0.914,0.542,1399,0.88,"ALDH3A1, BUD23, METTL2B, ALDH3A2",0.266000713461613,0.0555173278498314,FALSE
+"HCC95","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.46057,1.52,0.0604,3916,0.458,"SEM1, RAD51, EME1, POLD2, XRCC3, RPA3, BLM, SSBP1, RPA1, RAD51B, RAD51C, RAD51D, XRCC2",1.21896306137887,0.339134521996131,FALSE
+"HCC95","Input","KEGG_HUNTINGTONS_DISEASE",0.20404,0.654,0.936,2542,1,"HAP1, VDAC3, POLR2H, NDUFB5, NDUFB7, POLR2J, AP2M1, VDAC2, NRF1, NDUFS6, AP2B1, ATP5MC1, ATP5PD, PLCB1, POLR2G, NDUFA9, SIN3A, COX5A, TAF4B, CLTCL1, NDUFV2, NDUFB10, NDUFA4L2",0.0287241512618947,0,FALSE
+"HCC95","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.21308,-0.765,0.817,14891,1,"SGCD, LAMA2, LMNA, SGCA, PRKAB1, TNNC1, CACNB2, DES, RYR2, ITGA9, CACNA2D1, ITGA10, ITGB7, ITGB5, CACNA1C, DMD, CACNA2D4, CACNG6, CACNG8, PRKAA2, ITGA7, ITGA1, ACE, ITGB3, ITGB1, ACTB, TGFB3, TPM2",0.0877779434675845,0,FALSE
+"HCC95","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.21705,-0.782,0.737,17006,1,"ALDH6A1, PIK3C2A, PIP5K1C, PI4KA, SYNJ1, INPPL1, PIK3C3, PIP4K2A, PIP5K1A, PI4KB",0.132532512140949,0,FALSE
+"HCC95","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.29416,0.964,0.478,4615,0.841,"CALML3, PRKCI, ACACA, EIF4EBP1, IKBKB, GRB2, SREBF1, BAD, PIK3CA, PIK3R2, PHKB, IRS1, MAPK9, PRKACA, SOCS1, MAPK10, FLOT2, SLC2A4, FOXO1, RHEB, BRAF, PRKAA1, CBLC, FASN, PIK3CB, KRAS, EXOC7, HRAS, PHKA1, ACACB, PPP1CB, CRKL, PRKAG2, SH2B2, RPTOR, MAPK1, MAPK8, GCK, AKT2, PYGL, HK1, PRKCZ, PTPN1, PCK2, RAPGEF1",0.320572103387881,0.0752040042020878,FALSE
+"HCC95","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.18783,-0.68,0.928,11300,1,"CD80, PIGR, TNFSF13, IL4, AICDA, IL10, CCR9, CCL25, TNFRSF13C, IL6, CXCL12, IL5, CCR10, ITGB7, TNFSF13B, CXCR4, IL15, CCL28",0.0324520237811379,0,FALSE
+"HCC95","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.20593,-0.743,0.853,16363,1,"PIK3R3, PIK3R1, CSF2RA, IL3RA, CNTF, SOS1, IL15, IL11RA, STAT1, IL6ST, PIAS3, SPRY4, JAK2, LIF, SPRY2, SPRY3, IL11, STAM, JAK1, SOCS4, CLCF1, TYK2, IRF9, SOS2, STAT2, STAT5A",0.069050968832477,0,FALSE
+"HCC95","Input","KEGG_LEISHMANIA_INFECTION",0.24501,0.791,0.749,4896,0.961,"TRAF6, IL1A, PTPN6, MAPK13, MAPK12, NFKBIB, NOS2, IL1B, MAP3K7, FOS, TGFB2, MAPK1, MAPK14, PTGS2, MAPK11, NCF2, IL12A, ITGB2",0.125518182300534,0.0172766123314547,FALSE
+"HCC95","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.2144,-0.769,0.789,13995,1,"ESAM, VAV3, VCL, CXCL12, CLDN14, CTNNA2, CLDN2, CDH5, MYL5, ARHGAP5, CLDN15, VCAM1, PRKCG, RAPGEF3, PLCG1, CLDN10, JAM2, CYBB, PIK3R3, PIK3R1, CXCR4, CLDN9, GNAI3, RHOA, MYLPF, ROCK1, AFDN, EZR, TXK, CD99, CDC42, ITGB1, CLDN23, ACTB, PRKCA, BCAR1, RAP1B, RAP1A, MYL9, ICAM1, ROCK2, VASP, CYBA",0.10292299679058,0,FALSE
+"HCC95","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.45478,-1.61,0.046,18062,0.507,"YOD1, ALDH9A1, ALDH7A1",1.33724216831843,0.294992040666664,FALSE
+"HCC95","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.27548,0.895,0.593,2278,0.861,"AKR1B10, PLA2G4B, PLA2G4A, PLA2G12A",0.226945306635737,0.0649968485463452,FALSE
+"HCC95","Input","KEGG_LONG_TERM_DEPRESSION",0.22976,0.757,0.805,3896,0.993,"PPP2CA, NOS1, GNA13, PLA2G4B, PLCB1, LYN, GNAI1, ITPR3, PLA2G4A, PLA2G12A, BRAF, KRAS, HRAS, IGF1R, GNAZ, MAPK1, PPP2R1B",0.0942041196321315,0.00305075150461883,FALSE
+"HCC95","Input","KEGG_LONG_TERM_POTENTIATION",0.20946,0.678,0.899,4481,1,"CALML3, PPP3R2, PLCB1, ADCY1, CAMK4, PRKACA, ITPR3, RPS6KA1, BRAF, KRAS, HRAS, PPP1CB, MAPK1, CAMK2G, PLCB3, ATF4, CHP1",0.0462403082667712,0,FALSE
+"HCC95","Input","KEGG_LYSINE_DEGRADATION",0.2755,0.898,0.57,3357,0.872,"NSD3, EHHADH, PIPOX, ALDH3A2, NSD1, HADHA, EHMT2, NSD2, ACAT2, SETDB2, ALDH2",0.244125144327509,0.0594835150674328,FALSE
+"HCC95","Input","KEGG_LYSOSOME",0.21187,0.695,0.867,5662,1,"PSAPL1, AP3M2, SLC11A1, M6PR, ARSG, CTSV, LAMP3, AP3B1, GLA, HGSNAT, AP1S1, HEXB, LIPA, NAGLU, CLTCL1, GM2A, CD68, NAGPA, CTSH, AP3B2, GNPTAB, LAMP1, CLN5, AP3M1, PPT1, ATP6V0A2, AP1S3, NPC1, GAA, DNASE2, AP1M2, ATP6V0C, LAPTM4B, ABCA2, CTSZ, HEXA, NAGA, GGA2, CLTB, ATP6AP1, NPC2, CTSB, CLTC, PPT2, CTSF, LGMN, CTSL",0.0619809025237897,0,FALSE
+"HCC95","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.27399,0.895,0.589,3498,0.861,"TRAF6, NTRK2, MAP3K13, MAP4K1, PAK2, NTF4, FGFR2, RAC3, IL1A, CACNA2D3, NF1, HSPB1, PPP3R2, NLK, FGFR3, IKBKB, PDGFA, DUSP14, GRB2, HSPA1B, NGF, CACNG4, EGFR, PLA2G4B, MAPK13, GADD45G, MAPK9, PPM1B, PRKACA, MYC, PAK1, PLA2G4A, FGF1, MAPK10, PLA2G12A, SRF, CACNB1, DAXX, MAPK12, MAP2K6, DUSP9, RPS6KA1, BRAF, FGF12, DUSP3, IL1B, JUND, ARRB2, MAP3K7, RPS6KA5, CACNA1B, KRAS, PDGFB, FOS, HRAS, TAOK1, RPS6KA4, MAP2K5, CRKL",0.229884705212898,0.0649968485463452,FALSE
+"HCC95","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26424,0.856,0.651,4735,0.898,"MAFA, ONECUT1, HHEX, MNX1, GCK, FOXA2, HES1",0.186419011431808,0.0467236633326956,FALSE
+"HCC95","Input","KEGG_MELANOGENESIS",0.43383,1.42,0.0877,2279,0.499,"CALML3, WNT3A, FZD1, ADCY3, WNT5A, WNT8B, FZD10, DVL3, WNT10A, POMC, WNT7B, EDN1, WNT11, WNT10B, FZD9, PLCB1, WNT9A, ADCY1, WNT7A, WNT16, PRKACA, GNAI1, WNT4, LEF1",1.05700040663396,0.30189945437661,FALSE
+"HCC95","Input","KEGG_MELANOMA",0.27659,0.911,0.558,3418,0.849,"PDGFD, PDGFA, EGFR, BAD, PIK3CA, PIK3R2, RB1, FGF1, CDH1, BRAF, FGF12, MET, PIK3CB, KRAS, PDGFB, HRAS, IGF1R",0.253365801062421,0.0710923097560473,FALSE
+"HCC95","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.53409,1.74,0.0228,1394,0.364,"ADH7, AKR1C2, ALDH3A1, AKR1C1, DHDH, AKR1C3, CYP2S1, CYP1B1, EPHX1, UGT2B17, GSTM3",1.64206515299955,0.438898616350944,FALSE
+"HCC95","Input","KEGG_MISMATCH_REPAIR",0.58449,1.94,0.00923,4009,0.495,"RFC4, RFC2, PMS2, MSH6, PCNA, POLD2, RFC3, RPA3, SSBP1, RPA1, RFC5, EXO1",2.03479829897409,0.305394801066431,FALSE
+"HCC95","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.30304,0.988,0.413,4169,0.81,"EIF4EBP1, DDIT4, PIK3CA, PIK3R2, ULK2, RHEB, RPS6KA1, BRAF, PRKAA1, PIK3CB, EIF4B, RPTOR, MAPK1, AKT2, MLST8",0.384049948343599,0.0915149811213502,FALSE
+"HCC95","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.1681,0.541,0.996,3348,1,"SYK, RAC3, PPP3R2, ULBP1, MICB, PTPN6, GRB2, PIK3CA, PIK3R2, NFATC1, PAK1, MICA, TNFSF10, BRAF, LCK, BID, PIK3CB, KRAS, KIR2DL3, HRAS, ULBP3",0.00174066157630127,0,FALSE
+"HCC95","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.13459,0.436,1,2847,1,"P2RY1, ADRA2C, GABRB3, S1PR5, CHRNA7, CHRNB4, ADRA1A, CHRNA5, SSTR5, VIPR1, LPAR2, ADORA2B, PTAFR, ADRB2, MTNR1A, GRM4, P2RY13, CHRM3, TACR1, P2RY2, LPAR6, PTH2R, HTR2C, NMUR2, F2RL2, LPAR1",0,0,FALSE
+"HCC95","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.32583,1.07,0.344,4347,0.739,"CALML3, TRAF6, NTRK2, NTF4, YWHAG, NGFR, TP73, IKBKB, BCL2, GRB2, NGF, BAD, PIK3CA, PIK3R2, MAPK13, IRS1, CAMK4, MAPK9, MAPK10, MAPK12, NFKBIB, RPS6KA1, BRAF, PIK3CB, RPS6KA5, KRAS, HRAS, RPS6KA4, MAP2K5, CRKL, SH2B2, MAPK1, MAPK8, AKT2, CAMK2G, MAPK14, ATF4, MAPK11",0.46344155742847,0.131355561605174,FALSE
+"HCC95","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.37484,-1.35,0.124,16890,0.484,"AOX1, NMNAT2, NMNAT1, NT5E, NNT, NNMT, QPRT",0.906578314837765,0.315154638355588,FALSE
+"HCC95","Input","KEGG_NITROGEN_METABOLISM",0.38858,1.29,0.122,1305,0.54,"GLS2, GLUL, ASNS",0.913640169325252,0.267606240177031,FALSE
+"HCC95","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.33633,1.09,0.298,4347,0.709,"TRAF6, HSP90AB1, CASP1, IKBKB, MAPK13, MAPK9, MAPK10, TRIP6, MAPK12, NFKBIB, IL1B, PYCARD, MAP3K7, MAPK1, MAPK8, SUGT1, IL18, MAPK14, MAPK11",0.525783735923745,0.149353764816933,FALSE
+"HCC95","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.40163,-1.46,0.0733,16335,0.358,"POLM, RAD50, NHEJ1, DCLRE1C, LIG4",1.13489602535887,0.446116973356126,FALSE
+"HCC95","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.20338,-0.737,0.867,14914,1,"MAP2K2, PRKCG, PLCG1, TP53, E2F3, PIK3R3, PIK3R1, SOS1, RAF1, FHIT, PRKCA, CDKN2A, SOS2, RASSF1, ARAF",0.0619809025237897,0,FALSE
+"HCC95","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.23284,0.757,0.793,4735,0.993,"DLL1, DVL3, JAG2, MAML1, KAT2A, DLL3, JAG1, DVL2, DTX2, ADAM17, NOTCH1, HDAC1, MFNG, NUMBL, LFNG, HES1",0.100726812682396,0.00305075150461883,FALSE
+"HCC95","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.42598,1.4,0.097,3688,0.483,"RFC4, RAD23B, RFC2, GTF2H4, PCNA, POLE2, XPA, POLD2, POLE3, RFC3, RPA3, GTF2H3, RPA1, ERCC3, ERCC8, RFC5",1.01322826573376,0.316052869248488,FALSE
+"HCC95","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.42909,1.4,0.0901,4377,0.483,"ALG3, ALG12, MOGS, DOLPP1, MGAT1, B4GALT2, TUSC3, ALG2, ALG1, ALG14, DPAGT1, GANAB, DPM1, STT3A, RFT1, MGAT4B, ALG5, ALG11, MAN1B1, ALG10B, MGAT2, RPN2",1.04527520902094,0.316052869248488,FALSE
+"HCC95","Input","KEGG_OLFACTORY_TRANSDUCTION",0.33325,1.1,0.305,458,0.707,"OR10S1, CALML3, OR11H4, OR8A1, OR8G1, OR1G1, OR10H2, OR8D2, OR6C70, ADCY3, OR8G5",0.515700160653214,0.150580586203101,FALSE
+"HCC95","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.30475,0.998,0.407,5546,0.816,"MTFMT, TYMS, SHMT1, DHFR, MTHFD2, SHMT2, MTHFD1L, GART, MTHFD1",0.39040559077478,0.0883098412461389,FALSE
+"HCC95","Input","KEGG_OOCYTE_MEIOSIS",0.26634,0.868,0.637,4187,0.888,"CALML3, ADCY3, YWHAG, PPP3R2, ANAPC1, PPP2CA, CCNB2, FBXW11, PPP2R5D, ANAPC11, ADCY1, PRKACA, ITPR3, CDC23, MAPK12, CUL1, RPS6KA1, BUB1, CDC26, PKMYT1, CDC25C, IGF1R, PPP1CB, PTTG1, MAD2L2, MAPK1, PPP2R1B, CAMK2G, ANAPC7",0.19586056766465,0.051587034221399,FALSE
+"HCC95","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.34108,-1.25,0.175,13292,0.506,"FUCA2, MAN2C1, NEU4, GLB1, FUCA1, NEU1, GBA, AGA, MAN2B1, MANBA",0.756961951313706,0.295849483160201,FALSE
+"HCC95","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.20225,0.651,0.934,6278,1,"ATP6V1C2, ATP6V1E2, NDUFB5, NDUFB7, NDUFS6, ATP5MC1, ATP5PD, NDUFA9, COX5A, NDUFV2, NDUFB10, NDUFA4L2, COX10, COX11, LHPP, UQCRFS1, SDHD, NDUFA2, ATP6V0A2, ATP5MG, SDHA, ATP6V1G2, NDUFS4, NDUFA8, COX7C, ATP6V0C, COX5B, ATP6V0E2, CYC1, UQCRHL, NDUFV1, ATP5PO, UQCRC1, COX8A, ATP6AP1, ATP5F1A, NDUFA10, UQCRQ, PPA1, NDUFB8, ATP12A, ATP5MF, COX15, NDUFB9, NDUFB2, COX7A2L, ATP6V0A1, ATP5MC3",0.0296531237699066,0,FALSE
+"HCC95","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.35234,1.15,0.241,2264,0.68,"GCNT1, GALNT11, GALNT18, GALNT13, GALNT14, GALNT12",0.617982957425132,0.167491087293764,FALSE
+"HCC95","Input","KEGG_P53_SIGNALING_PATHWAY",0.31099,1.01,0.406,977,0.804,"TP53AIP1, SESN3, SERPINB5, TP73, EI24, CCNB2, SFN",0.391473966422806,0.0947439512515487,FALSE
+"HCC95","Input","KEGG_PANCREATIC_CANCER",0.28446,0.934,0.527,5488,0.848,"RAC3, IKBKB, RALBP1, RAD51, EGFR, BAD, PIK3CA, PIK3R2, MAPK9, PLD1, RB1, MAPK10, BRAF, PIK3CB, KRAS, TGFB2, MAPK1, MAPK8, AKT2, SMAD2, TGFBR1, TGFA, CCND1, RAC1, ERBB2, VEGFC, IKBKG, E2F2",0.278189384787453,0.0716041477432862,FALSE
+"HCC95","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3738,1.23,0.181,3596,0.605,"COASY, PANK2, PPCDC, PANK3, BCAT1, BCAT2",0.742321425130815,0.218244625347531,FALSE
+"HCC95","Input","KEGG_PARKINSONS_DISEASE",0.19697,0.645,0.961,2542,0.992,"VDAC3, SNCAIP, NDUFB5, NDUFB7, SNCA, VDAC2, NDUFS6, ATP5MC1, ATP5PD, UCHL1, NDUFA9, COX5A, NDUFV2, NDUFB10, NDUFA4L2",0.0172766123314547,0.00348832784582135,FALSE
+"HCC95","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.41106,-1.49,0.0615,16465,0.455,"YWHAQ, ARPC3, CD14, RHOA, ARPC4, TLR4, TUBA1A, ROCK1, EZR, TUBA8, CDC42, ITGB1, ACTB, PRKCA, TUBB2B, TUBB2A, ROCK2, ARHGEF2",1.21112488422458,0.341988603342888,FALSE
+"HCC95","Input","KEGG_PATHWAYS_IN_CANCER",0.30119,0.999,0.434,3708,0.824,"TRAF6, WNT3A, LAMA1, FZD1, FGFR2, RAC3, WNT5A, WNT8B, GLI2, COL4A6, FZD10, DVL3, WNT10A, HSP90AB1, SMO, WNT7B, FGFR3, IKBKB, WNT11, PDGFA, BCL2, GRB2, RALBP1, SKP2, RAD51, WNT10B, EGFR, BAD, PIK3CA, JUP, RXRA, PIK3R2, FZD9, LAMC2, WNT9A, MSH6, AXIN1, ITGA2, PTCH1, WNT7A, WNT16, MAPK9, CEBPA, MYC, LAMB3, PLD1, WNT4, RB1, FGF1, MAPK10, LEF1, GSTP1, FOXO1, CDH1, BCR, BRAF, FGF12, ITGA6, NOS2, CBLC, FZD6, BID, ITGA2B, MET, SLC2A1, PIK3CB, CCNA1, DVL2, KRAS, PDGFB, PML, FOS, TRAF4, LAMA3, HRAS, IGF1R, CRKL, ARNT2, TGFB2, BIRC5, LAMA5, EGLN3",0.362510270487489,0.0840727883028842,FALSE
+"HCC95","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.46084,1.52,0.0439,4360,0.458,"DHDH, DCXR, UGT2B17, AKR1B1, UGDH, RPEL1",1.35753547975788,0.339134521996131,FALSE
+"HCC95","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50449,1.65,0.0257,1720,0.435,"ALDOC, PGD, G6PD, TKT, TALDO1, GPI, PGLS, DERA",1.59006687666871,0.361510743045363,FALSE
+"HCC95","Input","KEGG_PEROXISOME",0.33945,1.11,0.267,2716,0.744,"CAT, ACSL6, PEX6, EHHADH, GNPAT, PRDX1, SLC27A2, PEX11G, PEX5, PIPOX, PXMP2, EPHX2, PEX2, PAOX, PEX10, ACSL3, CROT, NOS2",0.573488738635425,0.128427064454121,FALSE
+"HCC95","Input","KEGG_PHENYLALANINE_METABOLISM",0.44089,1.44,0.0735,2780,0.499,"ALDH3A1, AOC2, GOT2, AOC3, GOT1",1.1337126609158,0.30189945437661,FALSE
+"HCC95","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25236,0.813,0.714,3123,0.941,"CALML3, DGKH, PIK3CA, PIK3R2, PLCB1, DGKE, PIP4K2B, IMPA2, ITPR3, IPPK, PLCD1, CDS1, CDIPT, PIK3CB, CDS2",0.146301788223826,0.0264103765727431,FALSE
+"HCC95","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.25238,-0.902,0.535,18193,0.92,"CPOX, UROD, HMOX1, PPOX, HCCS",0.271646217978772,0.0362121726544447,FALSE
+"HCC95","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.31381,1.02,0.409,3022,0.813,"ACSL6, ME1, SCD, EHHADH, FADS2, OLR1, SLC27A2, PLTP, RXRA, CPT1A, SLC27A5, ACSL3, FABP6, SCD5, SLC27A6",0.388276691992658,0.0899094544059319,FALSE
+"HCC95","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.42226,-1.5,0.0747,15755,0.513,"CYP46A1, CYP7B1, CYP27A1, ACOX2, HSD3B7, SCP2",1.1266793981846,0.289882634888184,FALSE
+"HCC95","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.54243,1.8,0.00985,3590,0.354,"RAG1, RAG2, RFXANK, UNG, ADA, TAP2, RFXAP, LCK, CD8A, TAP1, CD40",2.00656376950239,0.450996737974212,FALSE
+"HCC95","Input","KEGG_PRION_DISEASES",-0.19563,-0.731,0.862,15964,1,"NCAM2, CCL5, PRKACB, NCAM1, C8G, HSPA1A, ELK1",0.0644927341752872,0,FALSE
+"HCC95","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.35234,1.15,0.264,4415,0.68,"ADCY3, HSP90AB1, ANAPC1, CCNB2, PIK3CA, PIK3R2, MAPK13, ANAPC11, ADCY1, MAPK9, PRKACA, GNAI1, MAPK10, CDC23, MAPK12, RPS6KA1, BRAF, BUB1, PIK3CB, CDC26, CCNA1, PKMYT1, KRAS, CDC25C, IGF1R, CCNA2, MAD2L2, MAPK1, MAPK8, AKT2, ANAPC7, MAPK14, MAPK11, CDC27",0.578396073130169,0.167491087293764,FALSE
+"HCC95","Input","KEGG_PROPANOATE_METABOLISM",0.31198,1.02,0.403,3769,0.813,"LDHC, EHHADH, ACACA, ACSS1, ALDH3A2, PCCB, ACSS2, HADHA, ACAT2, ALDH2, ACACB, LDHB",0.39469495385889,0.0899094544059319,FALSE
+"HCC95","Input","KEGG_PROSTATE_CANCER",0.28298,0.924,0.553,3418,0.864,"PDGFD, FGFR2, HSP90AB1, IKBKB, PDGFA, BCL2, GRB2, EGFR, BAD, PIK3CA, PIK3R2, RB1, LEF1, GSTP1, FOXO1, BRAF, PIK3CB, KRAS, PDGFB, HRAS, IGF1R",0.257274868695302,0.0634862575211067,FALSE
+"HCC95","Input","KEGG_PROTEASOME",0.41552,1.36,0.132,5428,0.496,"PSMD11, PSMD2, SEM1, PSME3, PSMC5, PSMD12, PSMD3, PSMC2, PSMA4, PSMB3, PSMD8, PSMF1, PSME4, PSMC1, PSMB9, PSMA7, PSMB6, PSMB8, PSMB10, PSMA2, PSMD7",0.87942606879415,0.304518323509803,FALSE
+"HCC95","Input","KEGG_PROTEIN_EXPORT",-0.29128,-1.08,0.312,17904,0.663,"SRPRB, SEC61A2, SEC63, SEC61A1",0.505845405981557,0.178486471595227,FALSE
+"HCC95","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.47173,1.54,0.0568,2389,0.51,"GLS2, SLC9A3, ATP1B3, SLC25A10, MDH1, ATP1A1",1.24565166428898,0.292429823902064,FALSE
+"HCC95","Input","KEGG_PURINE_METABOLISM",0.23092,0.754,0.809,5795,0.982,"ADCY10, POLR2H, GMPS, ADCY3, IMPDH1, NME2, POLR2J, POLR1D, ADA, ADK, AK7, ADCY1, POLR2G, HPRT1, POLE2, POLD2, POLE3, POLR3G, PRIM1, PAICS, NT5C, POLR1B, POLA2, POLR2D, PDE8B, NT5M, PFAS, ITPA, PRIM2, ENTPD2, PKM, PDE9A, POLR3F, NME3, GUCY1B1, POLR2J2, ADCY9, NME1, ENTPD6, POLR1C, POLR2I, PPAT, POLD1, POLR2C, GART, CANT1, POLD3, POLR3GL, POLR2F, RRM1, AK4",0.0920514783877277,0.00788851221305034,FALSE
+"HCC95","Input","KEGG_PYRIMIDINE_METABOLISM",0.27634,0.911,0.572,5758,0.849,"POLR2H, TK1, NME2, POLR2J, POLR1D, TXNRD1, TYMS, POLR2G, CAD, POLE2, POLD2, POLE3, POLR3G, DUT, PRIM1, NT5C, POLR1B, POLA2, POLR2D, NT5M, DTYMK, ITPA, PRIM2, DHODH, POLR3F, UPP1, NME3, POLR2J2, NME1, ENTPD6, POLR1C, POLR2I, POLD1, POLR2C, DCTD, CANT1, POLD3, POLR3GL, POLR2F, RRM1",0.242603971206976,0.0710923097560473,FALSE
+"HCC95","Input","KEGG_PYRUVATE_METABOLISM",0.33581,1.1,0.302,3776,0.707,"LDHC, ME1, ACACA, ACSS1, ALDH3A2, MDH2, MDH1, ACSS2, DLAT, ACAT2, AKR1B1, ALDH2, ACACB, LDHB, GLO1",0.519993057042849,0.150580586203101,FALSE
+"HCC95","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.19717,0.65,0.932,5149,0.995,"PDGFD, PAK2, FGFR2, RAC3, FGFR3, GIT1, FGD3, ENAH, PDGFA, GNA13, PFN2, EGFR, ARPC2, PIK3CA, PIK3R2, ITGB4, ITGA2, PIP4K2B, DIAPH1, PAK6, PAK1, FGF1, CHRM3, BRAF, FGF12, ITGA6, MYH14, ITGA2B, PIK3CB, KRAS, PDGFB, MYL12B, CYFIP1, HRAS, PPP1CB, CRKL, IQGAP2, SSH1, BDKRB2, MAPK1, PAK4, MSN, LIMK1, BDKRB1, MYL2, VAV2, PFN4, ARHGEF4, PDGFC, ITGB8, ITGAE, BAIAP2, ITGB2, FGFR4, ITGA3, SSH3, RAC1, ARHGAP35, MYH10, ITGB6",0.0305840876460186,0.00217691925427455,FALSE
+"HCC95","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.35227,-1.31,0.143,16573,0.472,"ATG4C, PRKAA2, ATG4A, ULK3, GABARAP, ATG7, ATG4B, PIK3C3, PIK3R4, ATG3",0.844663962534938,0.326058001365912,FALSE
+"HCC95","Input","KEGG_RENAL_CELL_CARCINOMA",0.22785,0.746,0.83,4107,0.988,"PAK2, GRB2, PIK3CA, PIK3R2, PAK6, PAK1, BRAF, MET, SLC2A1, PIK3CB, KRAS, PDGFB, HRAS, CRKL, ARNT2, TGFB2, EGLN3, MAPK1, PAK4, AKT2, ELOC",0.0809219076239261,0.00524305541237188,FALSE
+"HCC95","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.34171,1.14,0.257,2098,0.693,"CMA1, NLN, LNPEP",0.590066876668705,0.159266765388193,FALSE
+"HCC95","Input","KEGG_RETINOL_METABOLISM",0.42286,1.38,0.0989,197,0.506,"ADH7, RDH16, CYP26A1",1.00480370840282,0.295849483160201,FALSE
+"HCC95","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.40067,-1.47,0.0902,14086,0.432,"FLAD1, ACP4, PHPT1, ACP5, ACP2, ACP1",1.04479346245806,0.364516253185088,FALSE
+"HCC95","Input","KEGG_RIBOSOME",0.40256,1.32,0.132,4872,0.504,"RPL35A, RPS2, RPL12, RPLP1, RPL38, RPS17, RPL37, RPL13, RPL18A, RPS10, RPL23A, RPL27, RPL26L1, RPL22, RPS21, RPS16, RPL31, RPL22L1, RSL24D1, RPL26, RPL23, RPS18, RPL4, RPL8, RPL17, RPL19, RPS27A, RPL21, RPL7A, RPL10A, RPL3L, RPL35, FAU, RPS24, RPS23, UBA52, RPLP0, RPS3",0.87942606879415,0.297569463554475,FALSE
+"HCC95","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21245,0.694,0.894,4347,1,"TRAF6, IKBKB, MAPK13, MAPK9, MAPK10, NLRX1, MAPK12, NFKBIB, TKFC, MAVS, MAP3K7, ATG5, MAPK8, TRADD, MAPK14, MAPK11",0.0486624812040823,0,FALSE
+"HCC95","Input","KEGG_RNA_DEGRADATION",0.31295,1.01,0.405,3669,0.804,"LSM1, LSM4, LSM2, CNOT6, CNOT1, EXOSC8, EDC3, TENT4A, EXOSC2, EXOSC1, CNOT8, WDR61, HSPA9, XRN2, DCP2, LSM6, CNOT9",0.392544976785331,0.0947439512515487,FALSE
+"HCC95","Input","KEGG_RNA_POLYMERASE",0.41478,1.37,0.0984,5730,0.508,"POLR2H, POLR2J, POLR1D, POLR2G, POLR3G, POLR1B, POLR2D, POLR3F, POLR2J2, POLR1C, POLR2I, POLR2C, POLR3GL, POLR2F",1.00700490156866,0.294136287716081,FALSE
+"HCC95","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.38287,1.26,0.165,1510,0.564,"BUD23, METTL2B, MAT2B, AHCY",0.782516055786094,0.248720896016658,FALSE
+"HCC95","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.33346,1.1,0.303,5488,0.707,"TRAF6, LAMA1, COL4A6, IKBKB, BCL2, SKP2, PIK3CA, RXRA, PIK3R2, LAMC2, ITGA2, MYC, LAMB3, RB1, ITGA6, NOS2, ITGA2B, PIK3CB, TRAF4, LAMA3, LAMA5, AKT2, COL4A1, PTGS2, PTEN, CDKN1B, TRAF3, CCND1, PIAS2, ITGA3, COL4A4, ITGAV, IKBKG, COL4A2, E2F2",0.518557371497695,0.150580586203101,FALSE
+"HCC95","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.22491,-0.829,0.653,15588,0.958,"SNAP29, SNAP25, VTI1B, STX1A, BET1L, STX11, STX7, STX2, STX4, STX1B, VAMP5, SEC22B, STX12",0.185086818724926,0.0186344909214556,FALSE
+"HCC95","Input","KEGG_SPHINGOLIPID_METABOLISM",0.2859,0.95,0.498,3379,0.837,"SPTLC1, UGT8, GLA, KDSR, PLPP1, ACER3, PLPP2, SMPD4, ASAH2",0.302770657240282,0.07727454200674,FALSE
+"HCC95","Input","KEGG_SPLICEOSOME",0.36969,1.22,0.181,4681,0.588,"THOC3, NCBP2, DHX8, PPIL1, WBP11, LSM4, LSM2, TRA2B, SNRPE, NCBP1, HSPA1B, U2SURP, ZMAT2, CHERP, EFTUD2, DHX16, PRPF19, SF3B6, THOC1, SNRPC, SNRPB, ALYREF, EIF4A3, SART1, MAGOHB, DDX46, SRSF2, CDC5L, SNRPG, USP39, CRNKL1, AQR, CTNNBL1, SRSF8, TXNL4A, SNRNP200, PRPF4, DDX42, HNRNPA3, LSM6, PRPF6, PHF5A, HNRNPK, SRSF3, SNRPA, SRSF1, SNRNP40, HNRNPM, SNU13, SNRPD1, SRSF7, BUD31, SNRPF, HSPA2, SLU7",0.742321425130815,0.230622673923862,FALSE
+"HCC95","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.17776,-0.649,0.926,14597,0.972,"HK3, GBE1, PYGM, TREH, UGT2B7, GYS1, HK2, PGM2L1, PGM1, AMY2B",0.0333890133180656,0.0123337350737254,FALSE
+"HCC95","Input","KEGG_STEROID_BIOSYNTHESIS",0.59816,1.93,0.00134,4575,0.351,"CYP51A1, FDFT1, DHCR7, LIPA, LSS, SQLE, HSD17B7, NSDHL, TM7SF2, DHCR24, SC5D, CEL",2.87289520163519,0.454692883534176,FALSE
+"HCC95","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.45133,1.46,0.0881,1244,0.504,"AKR1C2, AKR1C1, SRD5A1, AKR1C3, HSD17B8, CYP1B1, UGT2B17",1.05502409158795,0.297569463554475,FALSE
+"HCC95","Input","KEGG_SULFUR_METABOLISM",-0.36818,-1.32,0.115,16790,0.495,"SULT2B1, CHST11, PAPSS2",0.939302159646388,0.305394801066431,FALSE
+"HCC95","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.22706,-0.851,0.683,11300,0.961,"CD80, C6, C9, ACTN2, C2, IL10, FCGR2B, FCGR2C, C7, SSB, C3, CTSG, TNF, GRIN2B, FCGR1A, ELANE, FCGR2A, TRIM21, C4A, C8G, C4B",0.165579296318467,0.0172766123314547,FALSE
+"HCC95","Input","KEGG_TASTE_TRANSDUCTION",-0.14525,-0.538,0.996,13138,0.996,"TAS2R1, SCNN1G, TAS2R9, TAS2R40, ASIC2, SCNN1B, PDE1A, TAS2R43, PLCB2, TAS1R3, ADCY4, KCNB1, TAS2R10, CACNA1A, GNG13, PRKACB, GNB1, ADCY6",0.00174066157630127,0.00174066157630127,FALSE
+"HCC95","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.27527,-1.02,0.37,13917,0.772,"ADO, CDO1, GGT5, CSAD",0.431798275933005,0.112382699664264,FALSE
+"HCC95","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.50713,1.65,0.0202,4441,0.435,"HMGCS1, HMGCR, ACAT2, MVK, IDI1",1.69464863055338,0.361510743045363,FALSE
+"HCC95","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.18184,-0.664,0.942,16691,1,"RHOA, ZFYVE9, ROCK1, NOG, INHBA, RBX1, ZFYVE16, ACVR2A, TGFB3, CDKN2B, PPP2R1A, ROCK2, THBS3, E2F5",0.0259490972071227,0,FALSE
+"HCC95","Input","KEGG_THYROID_CANCER",-0.27302,-0.982,0.447,17381,0.838,"TFG, PAX8, TCF7, PPARG, TCF7L2, TPR",0.349692476868064,0.0767559813697235,FALSE
+"HCC95","Input","KEGG_TIGHT_JUNCTION",0.28847,0.956,0.469,4552,0.841,"CLDN8, CLDN11, PPP2R2C, PRKCI, YES1, PPP2CA, EPB41L1, YBX3, JAM3, EXOC4, PRKCH, VAPA, GNAI1, CLDN4, CLDN7, CSNK2A2, MYH14, PRKCQ, CRB3, EXOC3, CLDN1, AMOTL1, F11R, KRAS, MYL12B, TJAP1, HRAS, PATJ, CSNK2A1, LLGL2, TJP1, PPP2R1B, SRC, AKT2, PRKCZ, CLDN16, MYL2, PTEN",0.328827157284917,0.0752040042020878,FALSE
+"HCC95","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.20404,0.661,0.92,4347,1,"TRAF6, IKBKB, PIK3CA, IRF5, PIK3R2, MAPK13, MAPK9, SPP1, MAPK10, MAPK12, MAP2K6, IL1B, TLR6, PIK3CB, MAP3K7, FOS, CD40, MAPK1, MAPK8, AKT2, CD86, MAPK14, MAPK11",0.0362121726544447,0,FALSE
+"HCC95","Input","KEGG_TRYPTOPHAN_METABOLISM",0.32699,1.09,0.297,1664,0.709,"CAT, EHHADH, CYP1B1, ALDH3A2, AFMID, KYNU",0.527243550682788,0.149353764816933,FALSE
+"HCC95","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.3788,1.26,0.17,4419,0.564,"IKBKB, MAFA, PIK3CA, PIK3R2, IRS1, MAPK9, SOCS1, MAPK10, SLC2A4, PIK3CB, CACNA1B, MAPK1, MAPK8, GCK, CACNA1D, HK1, PRKCZ, PKM",0.769551078621726,0.248720896016658,FALSE
+"HCC95","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.28898,0.951,0.511,4858,0.844,"IL1A, IL1B, GAD1, CD86, IL12A",0.291579099865287,0.073657553374345,FALSE
+"HCC95","Input","KEGG_TYROSINE_METABOLISM",0.48802,1.59,0.0399,2780,0.478,"ADH7, ALDH3A1, BUD23, AOC2, GOT2, METTL2B, AOC3, ADH5, GOT1",1.39902710431325,0.320572103387881,FALSE
+"HCC95","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29421,0.985,0.443,4493,0.807,"DLG1, PAK2, PPP3R2, IKBKB, PTPN6, GRB2, PIK3CA, PIK3R2, MAPK13, PAK6, NCK1, MAPK9, NFATC1, PAK1, MALT1, MAPK12, NFKBIB, LCK, PRKCQ, CBLC, PIK3CB, MAP3K7, CD8A, KRAS, FOS, HRAS, NCK2, MAPK1, PAK4, AKT2, NFATC3, MAPK14, MAPK11, CHP1, VAV2",0.35359627377693,0.0931264652779296,FALSE
+"HCC95","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.27263,0.891,0.596,3547,0.862,"TRAF6, UBA2, KLHL13, ANAPC1, FBXW11, FBXO2, UBE3C, UBE2H, HERC2, SKP2, UBE2S, UBE2D2, ANAPC11, UBE2B, PRPF19, TRIM37, BRCA1, SOCS1, CDC23, CUL1, UBE2O, KEAP1, UBE3A, ITCH, CBLC, UBR5, CDC26, RNF7, PML, FBXO4, UBE2Z, FANCL, ERCC8",0.224753740259764,0.0644927341752872,FALSE
+"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.44179,-1.61,0.0467,16289,0.507,"LARS2, PDHB, PDHA1",1.33068311943389,0.294992040666664,FALSE
+"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.31015,1.01,0.419,3596,0.804,"HMGCS1, EHHADH, AUH, MCCC1, ALDH3A2, PCCB, MCCC2, HADHA, ACAT2, BCAT1, IVD, OXCT1, ALDH2, HADHB, BCAT2",0.377785977033705,0.0947439512515487,FALSE
+"HCC95","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.20647,0.673,0.926,2730,1,"CALML3, ADCY3, ADRA1A, GNA13, PLA2G4B, PLCB1, ADORA2B, ADCY1, PRKCH, PRKACA, ITPR3, PLA2G4A, PLA2G12A, KCNMB3, BRAF, PRKCQ",0.0333890133180656,0,FALSE
+"HCC95","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.29995,-1.12,0.258,16613,0.607,"PRKACB, RAB11B, RAB5B, STX4, ADCY6, CREB3, CREB3L1, DCTN6, DYNC1I2, DYNC1LI1, RAB5A",0.58838029403677,0.216811308924742,FALSE
+"HCC95","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.25659,0.843,0.679,4481,0.901,"RAC3, HSPB1, PPP3R2, BAD, PIK3CA, PIK3R2, PLA2G4B, MAPK13, NFATC1, PLA2G4A, PLA2G12A, MAPK12, PIK3CB, KRAS, HRAS, MAPK1, SRC, AKT2, NFATC3, MAPK14, PTGS2, MAPK11, CHP1",0.168130225719498,0.045275209020937,FALSE
+"HCC95","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25168,-0.931,0.536,17767,0.874,"ACTB, PRKCA, KDELR1, ATP6V0B, SEC61A2, ATP6V1D, ATP6V1A, SEC61A1, ATP6V0D1",0.27083521030723,0.058488567365597,FALSE
+"HCC95","Input","KEGG_VIRAL_MYOCARDITIS",0.18653,0.602,0.961,924,1,"EIF4G1, RAC3, CAV1",0.0172766123314547,0,FALSE
+"HCC95","Input","KEGG_WNT_SIGNALING_PATHWAY",0.39701,1.32,0.135,2533,0.504,"WNT3A, SENP2, TBL1XR1, FZD1, RAC3, WNT5A, WNT8B, SFRP5, FZD10, DVL3, WNT10A, PPP3R2, WNT7B, NLK, PRICKLE1, PPP2CA, WNT11, FBXW11, WNT10B, PPP2R5D, FZD9, PLCB1, WNT9A, AXIN1, WNT7A, VANGL1, WNT16, MAPK9, PRKACA, MYC, NFATC1, WNT4, MAPK10, CSNK1A1, LEF1, CCND2, CCND3, CSNK2A2, CUL1",0.869666231504994,0.297569463554475,FALSE
+"H1975","Input","KEGG_ABC_TRANSPORTERS",0.22788,0.708,0.885,2824,0.95,"ABCA1, ABCB8, ABCG2, ABCB9, ABCB7, ABCA3, ABCA7",0.0530567293021746,0.0222763947111523,FALSE
+"H1975","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.27617,0.863,0.667,4088,0.898,"RPS6KB2, MAP2K2, CCNA1, MYC, ARAF, PPARD, PIM2, PIK3R2, CHUK, IKBKG, PIK3CA, RARA, STAT5B, MAPK1, PIK3CB",0.175874166083451,0.0467236633326956,FALSE
+"H1975","Input","KEGG_ADHERENS_JUNCTION",0.2968,0.933,0.552,6665,0.851,"SNAI1, RAC2, FER, ACTN1, RAC1, ACTB, INSR, MET, SORBS1, CDH1, PTPN1, WASL, MAPK1, RHOA, SNAI2, VCL, EGFR, IQGAP1, CSNK2A1, SMAD4, EP300, SMAD3, TJP1, PTPN6, PTPRF, ACTG1, PARD3, TGFBR1, TGFBR2, NECTIN4, ERBB2, TCF7, NECTIN1, BAIAP2",0.258060922270801,0.0700704399154121,FALSE
+"H1975","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.346,-1.31,0.148,17878,1,"MAPK10, PRKCQ, ADIPOR2, PRKAG1, PPARGC1A, JAK2, AKT3, PCK2, PRKAA2, NFKBIB, ADIPOR1, NFKBIE, PRKAB1, AKT2",0.829738284605043,0,FALSE
+"H1975","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.29001,0.912,0.587,3808,0.874,"ASL, GFPT2, GLS, GLUD1, GOT2, ASS1, CPS1, ADSL",0.231361898752386,0.058488567365597,FALSE
+"H1975","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.1833,0.571,0.99,4088,0.978,"ATP1A2, INSR, PRKCA, SFN, PIK3R2, FXYD4, IRS1, PIK3CA, MAPK1, PIK3CB",0.00436480540245009,0.00966114521239857,FALSE
+"H1975","Input","KEGG_ALLOGRAFT_REJECTION",0.35646,1.11,0.295,2347,0.681,"IL12B, CD40",0.530177984021837,0.166852888087215,FALSE
+"H1975","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.22711,-0.832,0.611,12217,0.974,"PLA2G4E, PLA2G12B, PLA2G2F, PLA2G5, PLA2G2A, ACOX3, PLA2G1B, PLA2G3, PLA2G10, PLA2G4A, PLA2G4B",0.213958789757446,0.0114410431213845,FALSE
+"H1975","Input","KEGG_ALZHEIMERS_DISEASE",0.28996,0.904,0.593,5115,0.875,"NDUFV1, COX8C, GRIN2A, UQCR11, NDUFS8, CALM1, UQCR10, NDUFA7, ATP5F1B, GRIN1, NDUFB7, COX6B2, BACE1, GRIN2D, NDUFA6, SDHA, FADD, APH1A, NDUFS2, CASP8, NDUFB2, NDUFS7, NDUFA3, SDHC, UQCRC1, ITPR1, ATP5F1D, PSEN1, NDUFB6, NDUFA8, EIF2AK3, CAPN2, HSD17B10, PPP3CA, GSK3B, NAE1, CYCS, MAPK1, COX7B, NDUFA5, APBB1, NDUFV3, ATP2A3, CDK5, NDUFB10, IDE, TNFRSF1A, ITPR3, NDUFA4, PSEN2, NDUFS6, ATF6",0.226945306635737,0.0579919469776868,FALSE
+"H1975","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.56287,1.74,0.0199,2635,0.461,"FARS2, FARSA, TARS2, DARS2, LARS2, IARS2, CARS2, EARS2",1.70114692359029,0.336299074610352,FALSE
+"H1975","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.43562,1.37,0.101,5221,0.496,"GCK, GFPT2, GNPDA1, GMPPA, CYB5R3, HK2, RENBP, GMPPB, NANP, GALK1, PGM2, AMDHD2, NANS, UAP1, UGDH, HEXB, HK1, NAGK, PMM1, GNPNAT1, UGP2",0.995678626217357,0.304518323509803,FALSE
+"H1975","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28289,0.884,0.631,3910,0.877,"CCS, GRIN2A, GRIN1, TP53, GRIN2D, RAC1, TOMM40L, GPX1, MAPK12, CAT, PPP3CA, CYCS, MAPK13",0.199970640755866,0.0570004066339595,FALSE
+"H1975","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.33851,1.07,0.333,5574,0.733,"HSP90AA1, LGMN, CIITA, KLRC1, IFI30, CD74, HSPA1A, CTSL, HSPA2, NFYA, HSPA1B, HSPA8, KIR2DL1, CTSS, CTSB, TAP2, PSME1, CALR, CREB1, RFXANK, RFX5, PSME2, PSME3",0.47755576649368,0.134896025358872,FALSE
+"H1975","Input","KEGG_APOPTOSIS",0.24908,0.78,0.79,4699,0.96,"PRKAR1B, IL1RAP, TP53, ENDOD1, AIFM1, FADD, IRAK1, TRADD, CASP8, CASP10, IL1R1, IRAK4, PRKACA, PIK3R2, XIAP, CHUK, IKBKG, PRKAR2A, PIK3CA, CAPN2, PPP3CA, MYD88, CYCS, PIK3CB, RIPK1, DFFA, TNFRSF1A",0.102372908709559,0.0177287669604316,FALSE
+"H1975","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.32602,1.03,0.412,2668,0.755,"CYP2C9, CYP2E1, GPX4, CYP2C8, PLA2G2C, PTGES2, PTGES, GPX3, GPX1",0.385102783966865,0.122053048370812,FALSE
+"H1975","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.4526,1.41,0.0961,3980,0.465,"NOS3, ASL, ALDH9A1, SAT2, SMS, GLS, OAT, GLUD1, MAOB, ALDH1B1, GOT2, P4HA1, P4HA3, ASS1, SRM, NAGS, CPS1, MAOA",1.01727661233145,0.332547047110046,FALSE
+"H1975","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.25699,-0.962,0.455,15938,1,"CACNG7, ITGA7, SGCD, ITGA9, ACTN2, CACNA2D3, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, ITGA4, ATP2A2, SLC8A1, DMD, LEF1, PKP2, CACNA2D1, ITGB8, CDH2",0.341988603342888,0,FALSE
+"H1975","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.31672,0.982,0.473,4264,0.833,"ALDH9A1, ALDH1B1, UGDH",0.325138859262188,0.0793549985932124,FALSE
+"H1975","Input","KEGG_ASTHMA",0.51364,1.6,0.0301,16,0.363,"RNASE3",1.52143350440616,0.440093374963888,FALSE
+"H1975","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.39029,-1.43,0.0698,10027,1,"IFNA4, TSHR, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, FASLG, TSHB, CD80, IFNA13, CTLA4, IL10, IFNA21, PRF1, TPO, IFNA8, CGA, IFNA1, IFNA5, CD86, GZMB, FAS, TG, IL5",1.15614457737684,0,FALSE
+"H1975","Input","KEGG_AXON_GUIDANCE",0.30621,0.962,0.501,5502,0.835,"SEMA5B, LIMK1, PAK6, NGEF, RAC2, ABLIM3, NTN1, EPHB4, PAK2, SEMA4B, EFNA4, RASA1, RAC1, EFNA1, SEMA7A, PAK1, SEMA3A, SEMA3B, MET, GNAI2, ABLIM1, CFL2, ABLIM2, UNC5A, PLXNB3, PPP3CA, GSK3B, NFATC3, NRP1, EPHA1, MAPK1, SRGAP1, RHOA, EPHB2, SEMA6C, EPHA6, CDK5, ROCK2, ABL1, EFNB2, SEMA3C, SEMA6B, RHOD, SEMA3E, ITGB1, ROBO3, SRGAP2, GNAI1, SEMA4C, EFNA5",0.300162274132754,0.0783135245163979,FALSE
+"H1975","Input","KEGG_BASAL_CELL_CARCINOMA",-0.21862,-0.805,0.712,15646,0.982,"WNT2B, FZD5, GLI1, WNT7A, DVL3, WNT8B, FZD7, WNT6, HHIP, WNT10A, AXIN2, WNT4, WNT11, WNT5A, FZD8, FZD1, LEF1, WNT5B, SMO",0.147520006363144,0.00788851221305034,FALSE
+"H1975","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.26325,-0.947,0.411,17864,1,"TAF13, GTF2F2, GTF2B, STON1, GTF2A2, GTF2H2",0.386158178123931,0,FALSE
+"H1975","Input","KEGG_BASE_EXCISION_REPAIR",0.37222,1.17,0.219,4598,0.597,"POLD4, POLD2, NTHL1, SMUG1, APEX2, APEX1, OGG1, MBD4, PARP2, POLE3, POLE2, PCNA, PARP3, POLE4",0.659555885159882,0.224025668870631,FALSE
+"H1975","Input","KEGG_BETA_ALANINE_METABOLISM",0.54922,1.69,0.02,4373,0.298,"AOC2, ALDH9A1, SMS, AOC3, ECHS1, ALDH1B1, HADHA, SRM, EHHADH",1.69897000433602,0.525783735923745,FALSE
+"H1975","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.34961,1.09,0.323,4115,0.7,"ELOVL6, HACD1, ACAA1, HADHA, ACOT4, ACOT1, SCD",0.490797477668897,0.154901959985743,FALSE
+"H1975","Input","KEGG_BLADDER_CANCER",-0.26046,-0.984,0.456,17226,1,"FGFR3, EGF, E2F2, HRAS, CXCL8, MMP2, MDM2, VEGFC, KRAS, RB1",0.341035157335565,0,FALSE
+"H1975","Input","KEGG_BUTANOATE_METABOLISM",0.36894,1.15,0.245,3682,0.624,"ALDH9A1, ECHS1, PDHA1, ACAT1, ALDH1B1, HADHA, L2HGDH, OXCT1, PDHB, ACSM3",0.610833915635468,0.204815410317576,FALSE
+"H1975","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.2891,0.903,0.589,4395,0.868,"CD79A, CD19, VAV1, MAP2K2, RAC2, LILRB3, CARD11, RAC1, LYN, PIK3R2, IFITM1, CHUK, IKBKG, PIK3CA, PPP3CA, GSK3B, NFATC3, MAPK1, PIK3CB, VAV2, PLCG2",0.229884705212898,0.0614802748235081,FALSE
+"H1975","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.27157,0.85,0.68,2913,0.891,"NOS3, P2RX6, GRIN2A, MYLK2, PTGER1, P2RX5, GNA15, CALM1, GRIN1, CACNA1B, CACNA1A, ADCY7, GNA11, PHKA1, ADORA2B, EDNRA, ADORA2A, HRH1, MYLK, GRIN2D, TBXA2R, SPHK1, PRKCA, F2R, TRPC1, ITPR1, PRKACA, SLC25A5, ATP2B1, ATP2B4",0.167491087293764,0.0501222959631252,FALSE
+"H1975","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.24677,-0.904,0.587,16714,1,"CACNA2D3, CACNA2D4, ATP1B1, CACNB4, UQCRFS1, CACNA1C, RYR2, CACNA1D, SLC9A1, TPM2, UQCRHL, ATP2A2, TNNC1, SLC8A1, COX7A2, ATP1A3, CYC1, COX6A1, CACNA2D1, COX6B1",0.231361898752386,0,FALSE
+"H1975","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.19139,-0.719,0.879,16314,0.968,"NRXN2, CD6, ITGA9, NLGN4X, SDC2, CNTN1, CD4, ESAM, JAM2, CNTNAP2, CDH4, ITGAM, NRXN3, NCAM2, NEGR1, MPZL1, NLGN1, NCAM1, ITGA4, NFASC, NECTIN2, NRCAM, JAM3, CLDN1, ITGB8, CDH2",0.0560111249262281,0.0141246426916063,FALSE
+"H1975","Input","KEGG_CELL_CYCLE",0.37701,1.18,0.23,5773,0.606,"SMC1B, YWHAH, CCNA1, ATR, DBF4, MYC, CDC25B, FZR1, CDK7, TP53, CCNB1, CUL1, PLK1, YWHAQ, CDKN1C, RBL1, BUB3, GADD45B, SFN, CDC20, ESPL1, SMC1A, MCM7, TFDP2, STAG2, BUB1, YWHAE, CCNH, TGFB2, CHEK1, GSK3B, ORC5, CDC45, PCNA, MCM2, E2F4, CDKN2B, TGFB3, MCM6, CDC27, ORC2, ABL1, CDC25C, SMAD4, PKMYT1, ANAPC2, MCM5, SMC3, CHEK2, EP300, ORC6, SMAD3, CDK4, ANAPC1, CDKN2A, SKP1, TTK, E2F1, CDC6, YWHAG",0.638272163982407,0.217527375833714,FALSE
+"H1975","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.20737,-0.746,0.8,16907,0.998,"ADCY5, GNG5, XCL1, NFKBIA, CXCL1, SHC2, CSK, CXCL3, ELMO1, GNG2, CXCR4, PIK3CD, HRAS, CXCL8, PRKACB, CCL20, JAK2, ADCY1, PTK2, GNB1, AKT3, PLCB4, PIK3R1, KRAS, ADCY6, GNG4, NFKBIB, PLCB1, CXCL16, AKT2, GSK3A",0.0969100130080564,0.000869458712628891,FALSE
+"H1975","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.20631,0.645,0.938,5841,0.977,"MAP2K2, MYC, ARAF, TP53, MECOM, CRK, SHC3, PIK3R2, CHUK, IKBKG, TGFB2, PIK3CA, BCR, STAT5B, MAPK1, CTBP2, PIK3CB, TGFB3, RUNX1, ABL1, SMAD4, BRAF, CBLC, SMAD3, AKT1, CDK4, CDKN2A, E2F1, TGFBR1",0.0277971616209356,0.0101054362812269,FALSE
+"H1975","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.43941,-1.57,0.0483,16670,1,"PER2, CRY2, CSNK1D, CRY1",1.31605286924849,0,FALSE
+"H1975","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.47633,1.49,0.046,3635,0.424,"PC, IDH3G, IDH3B, MDH2, DLD, PDHA1, SDHA, SDHC, OGDH, CS, PDHB, ACO2",1.33724216831843,0.372634143407267,FALSE
+"H1975","Input","KEGG_COLORECTAL_CANCER",0.24649,0.769,0.809,5841,0.962,"RAC2, MYC, ARAF, TP53, RAC1, MLH1, PIK3R2, MSH6, APPL1, APC, TGFB2, PIK3CA, GSK3B, CYCS, MAPK1, RHOA, PIK3CB, TGFB3, SMAD4, RALGDS, BRAF, SMAD3, AKT1, AXIN1, FOS, TGFBR1",0.0920514783877277,0.0168249279621871,FALSE
+"H1975","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.33882,1.06,0.35,2604,0.738,"C4B, C4A, SERPINA5, PROS1, SERPINA1, CFB, F8, C3, SERPINE1, PLAU, F2R, TFPI",0.455931955649724,0.131943638176958,FALSE
+"H1975","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.41449,1.3,0.134,3574,0.474,"LDHC, LDHA, SMS, DNMT1, ADI1, AHCY, LDHAL6B, GOT2, MTR, SRM",0.872895201635192,0.324221658325915,FALSE
+"H1975","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20255,0.639,0.948,3472,0.975,"CRLF2, CSF1R, IL12B, EPOR, TNFRSF18, TNFRSF11A, CLCF1, TNFRSF6B, TNFSF9, AMH, IL7R, BMP2, IL11, IL13RA1, IL1RAP, CCL26, IL24, TNFSF12, CD70, OSMR, IL4R, IL15RA, CD40, IL1R1, CX3CL1, CCL28, MET, ACVR1B, IL6R, LIFR, CSF1, KITLG, CTF1, CCR4, TGFB2",0.0231916626619338,0.0109953843014632,FALSE
+"H1975","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.27408,0.859,0.668,3898,0.889,"AIM2, MAVS, ADAR, POLR3H, POLR3G, POLR3A, DDX58, POLR3GL, CHUK, IKBKG, POLR1C",0.175223537524454,0.0510982390297863,FALSE
+"H1975","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22818,-0.839,0.69,14422,0.986,"IGF1, CACNG1, ADRB1, ACTC1, ADCY2, ITGA1, TGFB1, TNNT2, SGCG, CACNA2D2, ADCY4, TNF, CACNG7, ITGA7, SGCD, ITGA9, CACNA2D3, ADCY5, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, TPM2, ITGA4, ATP2A2, PRKACB, TNNC1, SLC8A1, ADCY1, DMD, CACNA2D1, ADCY6, ITGB8",0.161150909262745,0.0061230850587888,FALSE
+"H1975","Input","KEGG_DNA_REPLICATION",0.48318,1.52,0.0563,5008,0.469,"POLD4, POLD2, RPA3, RNASEH2A, RNASEH1, PRIM1, SSBP1, RFC2, MCM7, POLE3, RNASEH2C, POLE2, RPA1, PCNA, MCM2, MCM6, POLE4, MCM5",1.24949160514865,0.328827157284917,FALSE
+"H1975","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.19145,-0.718,0.868,12053,0.946,"SOS2, MAP2K1, ETV6, NOTCH4, PIWIL4, PIWIL3, PIWIL2, PIWIL1, ETV7, NOTCH3, CPEB1, FMN2, KRAS",0.0614802748235081,0.0241088635982073,FALSE
+"H1975","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.40864,1.29,0.14,4256,0.483,"CYP2C9, GSTT2, CYP2E1, ALDH3B1, CYP2C8, GSTZ1, GSTO2, ALDH3B2, GSTK1, MAOB, AOX1, MGST1, MGST3, MAOA, FMO4, GSTP1",0.853871964321762,0.316052869248488,FALSE
+"H1975","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.42535,1.33,0.12,3217,0.519,"IMPDH2, CDA, HPRT1, UPP1, IMPDH1, UMPS, TYMP, UCK2, ITPA, TK2",0.920818753952375,0.284832642151542,FALSE
+"H1975","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.20917,-0.791,0.74,15893,0.987,"CD36, ITGA7, COL11A1, COL5A3, THBS2, HSPG2, ITGA9, SDC2, VWF, LAMA5, COL4A4, COL3A1, LAMA2, LAMC3, LAMA1, SV2A, COL5A2, ITGA4, LAMA4, ITGB8, COL4A1, COL4A2, LAMB1",0.130768280269024,0.00568284733036327,FALSE
+"H1975","Input","KEGG_ENDOCYTOSIS",0.24636,0.762,0.811,5364,0.966,"CSF1R, CHMP2A, RABEP1, EPN1, SMURF1, CHMP3, SH3KBP1, RAB31, LDLR, DNM2, GRK5, PIP5K1C, RAB11B, GRK3, HSPA1A, PLD2, F2R, RBSN, HSPA2, MET, STAM, SH3GL1, AP2M1, EHD2, GRK2, IQSEC1, PDCD6IP, ITCH, AGAP1, HSPA1B, CHMP4C, AP2B1, HSPA8, EPN3, MVB12A, ARF6, ARFGAP3, PSD4, CLTCL1, VPS45, ACAP1, ARRB1, CLTC, RNF41, EGFR, EEA1, ADRB2, STAM2, CHMP2B, CBLC, RAB11FIP2, SNF8, RAB11FIP1, ARFGAP1",0.090979145788844,0.0150228735845067,FALSE
+"H1975","Input","KEGG_ENDOMETRIAL_CANCER",0.24916,0.778,0.782,4970,0.955,"MAP2K2, MYC, ARAF, PTEN, TP53, MLH1, ELK1, PIK3R2, APC, CDH1, PIK3CA, GSK3B, FOXO3, MAPK1, PIK3CB, EGFR, PDPK1, BRAF",0.106793246940152,0.0199966284162537,FALSE
+"H1975","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23816,0.74,0.833,4626,0.984,"ATP6V0D2, NOD1, ATP6V0D1, RAC1, MAP2K4, LYN, PAK1, ATP6V1D, MET, ATP6V1F, ATP6V1E2, MAPK12, CHUK, IKBKG, MAPK13, TCIRG1, F11R, ATP6V0E2, PLCG2, EGFR",0.0793549985932124,0.00700490156865849,FALSE
+"H1975","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.24386,0.755,0.814,5113,0.969,"RPS6KB2, MAP2K2, PAK6, MYC, ARAF, PAK2, MAP2K4, CRK, ABL2, PRKCA, ELK1, PAK1, SHC3, MAP2K7, PIK3R2, PIK3CA, GSK3B, STAT5B, MAPK1, PIK3CB, NRG1, PLCG2, EGFR, ABL1, BRAF, CBLC, CAMK2D",0.0893755951107988,0.0136762229492347,FALSE
+"H1975","Input","KEGG_ETHER_LIPID_METABOLISM",0.29926,0.94,0.52,4032,0.842,"LPCAT1, PLA2G2C, PAFAH1B1, PLPP2, PLD2, AGPS, PLA2G12A, LPCAT2",0.283996656365201,0.0746879085003505,FALSE
+"H1975","Input","KEGG_FATTY_ACID_METABOLISM",0.41741,1.3,0.132,4656,0.474,"GCDH, ALDH9A1, ACSL4, ACAA1, ECHS1, ACSL5, ACAT1, ALDH1B1, HADHA, ACADVL, CPT1C, ACADSB, EHHADH, ACAA2",0.87942606879415,0.324221658325915,FALSE
+"H1975","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.2102,-0.763,0.801,16759,1,"MAPK11, INPP5D, PLA2G10, IL13, PLCG1, PLA2G4A, MAPK10, PIK3CD, HRAS, PLA2G4B, AKT3, PIK3R1, GAB2, KRAS, MAP2K6, AKT2",0.0963674839157623,0,FALSE
+"H1975","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.27975,0.872,0.628,4395,0.887,"RPS6KB2, VAV1, LIMK1, RAC2, PLA2G4D, ARPC1A, DNM2, PIP5K1C, RAC1, CRK, LYN, ARPC1B, MYO10, SPHK1, PRKCA, PAK1, PLPP2, PLD2, PIK3R2, CFL2, PIK3CA, WASL, ARF6, MAPK1, PRKCD, PIK3CB, VAV2, PLCG2",0.202040356262804,0.0520763801682736,FALSE
+"H1975","Input","KEGG_FOCAL_ADHESION",0.22691,0.711,0.874,5199,0.954,"PPP1CA, VAV1, MYLK2, THBS3, PAK6, RAC2, COL5A1, PTEN, ARHGAP5, ITGA5, ITGA2B, PAK2, LAMB3, PIP5K1C, ITGB3, ACTN1, TNC, MYLK, RAC1, ACTB, CRK, CAV2, PRKCA, FLNA, ELK1, ZYX, PAK1, SHC3, CAV1, DIAPH1, MYL9, MET, VTN, MYL7, PIK3R2, XIAP, LAMA3, PIK3CA, COL1A1, PPP1CB, CAPN2, GSK3B, MAPK1, BCAR1, ITGA3, RHOA, PIK3CB, FN1, VAV2, COL1A2, VCL, EGFR, ROCK2, LAMB2, PDPK1, FLNB, ITGA2, LAMC2, BRAF, DOCK1, LAMC1, ITGB1",0.058488567365597,0.0204516252959049,FALSE
+"H1975","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.3703,-1.34,0.142,12122,1,"ALPI, ALPL, ALPG, QDPR, ALPP, PTS, GGH, GCH1",0.847711655616944,0,FALSE
+"H1975","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.44997,1.39,0.0985,7631,0.472,"ALDOA, FBP1, PFKFB4, ALDOC, GMPPA, AKR1B1, HK2, GMPPB, PFKP, HK1, PFKFB3, PMM1, SORD, MTMR2, PFKFB1, MPI, PFKFB2, PFKL, PFKM, PMM2, FBP2, GMDS, MTMR1",1.00656376950239,0.326058001365912,FALSE
+"H1975","Input","KEGG_GALACTOSE_METABOLISM",0.4783,1.5,0.038,6884,0.451,"GCK, AKR1B1, HK2, GALK1, PGM2, PFKP, GLA, HK1, UGP2, GAA, PGM1, B4GALT1, GALE, PFKL",1.42021640338319,0.345823458122039,FALSE
+"H1975","Input","KEGG_GAP_JUNCTION",-0.22836,-0.842,0.636,15831,1,"TUBB4A, GNAI3, DRD2, GUCY1B1, HTR2C, PDGFD, ADCY5, PDGFRA, GUCY1A2, PRKG1, PRKG2, GUCY1A1, TUBB1, EGF, CSNK1D, HRAS, PRKACB, MAP2K5, ADCY1, PLCB4, KRAS, ADCY6, LPAR1, PLCB1",0.196542884351586,0,FALSE
+"H1975","Input","KEGG_GLIOMA",-0.26745,-1,0.446,17036,1,"PDGFRA, CALML6, CAMK2B, SHC2, EGF, PLCG1, E2F2, PIK3CD, HRAS, AKT3, PIK3R1, MDM2, KRAS, RB1, AKT2",0.350665141287858,0,FALSE
+"H1975","Input","KEGG_GLUTATHIONE_METABOLISM",0.41165,1.3,0.126,4822,0.474,"GSTT2, GPX4, ANPEP, GSTZ1, GSTO2, SMS, GSTK1, GPX3, GPX1, RRM2, MGST1, SRM, MGST3, GSTP1, G6PD, GGCT, ODC1, GGT7, GSTM2, GSS",0.899629454882437,0.324221658325915,FALSE
+"H1975","Input","KEGG_GLYCEROLIPID_METABOLISM",0.40366,1.27,0.139,4681,0.49,"GPAT2, DGKI, LIPG, AWAT2, ALDH9A1, DGKD, AKR1B1, AGK, DGKG, ALDH1B1, PLPP2, GPAT3, MGLL, MBOAT2, GK, AGPAT4, GLA, DGKE, GPAM",0.856985199745905,0.309803919971486,FALSE
+"H1975","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33238,1.04,0.389,4681,0.77,"GPAT2, DGKI, LPCAT1, PLA2G2C, MBOAT7, CDS2, PEMT, CRLS1, DGKD, DGKG, CHKA, PLPP2, PLD2, GPAT3, CHAT, PISD, CDIPT, MBOAT2, PLA2G12A, LPCAT2, AGPAT4, PCYT1A, DGKE, GPAM",0.410050398674292,0.113509274827518,FALSE
+"H1975","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.47415,1.47,0.0645,3268,0.442,"SARDH, AOC2, SRR, AOC3, DLD, SHMT1, MAOB, GCAT, PSPH, SHMT2",1.19044028536473,0.354577730650908,FALSE
+"H1975","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.50151,1.57,0.0294,2784,0.393,"GCK, LDHC, ALDH3B1, ALDOA, PGK1, LDHA, FBP1, ALDH9A1, ALDH3B2, ALDOC, DLD, PDHA1, GALM, PGAM1, LDHAL6B, ALDH1B1, HK2",1.53165266958784,0.405607449624573,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36869,1.17,0.227,5040,0.597,"CHST15, CHPF2, CHPF, CHST3, DSE, CHST11, CHST12, UST",0.643974142806877,0.224025668870631,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.19621,-0.729,0.752,12537,0.975,"HS3ST1, HS2ST1, NDST4, HS3ST2, HS6ST1, NDST2, EXTL1, HS3ST5, HS6ST3, NDST3, B3GAT1, B3GAT2, XYLT1",0.123782159408358,0.0109953843014632,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.48123,1.49,0.0596,1059,0.424,"CHST4, CHST6, FUT8, B3GNT7",1.22475374025976,0.372634143407267,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.41649,1.28,0.131,4328,0.48,"IDS, HYAL2, HYAL3, GALNS, HS3ST3B1, HYAL1, NAGLU, HEXB",0.882728704344236,0.318758762624413,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.24119,-0.911,0.531,14944,1,"B3GALT4, ST8SIA5, ST6GALNAC5, ST6GALNAC3, HEXA, ST3GAL5",0.274905478918531,0,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.43308,1.36,0.115,6501,0.502,"FUT2, B3GALNT1, ST3GAL2, GLA, HEXB, A4GALT, NAGA, ST8SIA1, GBGT1, B3GALT5",0.939302159646388,0.299296282854981,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.23892,-0.88,0.62,15377,1,"ST3GAL4, ST3GAL3, B3GALT2, FUT9, B3GALT1, B3GNT2, B4GAT1, B4GALT4, ST3GAL6",0.207608310501746,0,FALSE
+"H1975","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.27147,0.829,0.702,6205,0.925,"PIGQ, PIGL, PIGW, DPM2, PIGX, PIGH, PIGA, PIGG, PIGM, PIGB, PIGV, PIGN, PGAP1",0.153662887870195,0.0338582672609674,FALSE
+"H1975","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.35487,1.09,0.316,4253,0.7,"MTHFD1, MDH2, CS, ACO2, HYI",0.500312917381596,0.154901959985743,FALSE
+"H1975","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.22997,-0.851,0.636,16759,1,"MAPK11, ADCY5, PLA2G10, CACNA1C, CALML6, CAMK2B, CACNA1D, PLA2G4A, MAPK10, HRAS, PRKACB, PLA2G4B, MMP2, GNRH1, ADCY1, PLCB4, KRAS, ADCY6, ATF4, PLCB1, MAP2K6",0.196542884351586,0,FALSE
+"H1975","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.26642,-1,0.396,14812,1,"KLRD1, CD86, GZMB, FAS, TNF, IL1A, IL1B",0.402304814074488,0,FALSE
+"H1975","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.23504,-0.84,0.606,17337,1,"HHIP, WNT10A, WNT4, WNT11, GAS1, CSNK1D, WNT5A, BMP6, BMP7, PRKACB, WNT5B, SMO",0.217527375833714,0,FALSE
+"H1975","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.31328,0.97,0.489,3553,0.844,"CSF1R, CD19, EPOR, ANPEP, IL7R, IL11, ITGA5, ITGA2B, ITGB3, IL4R, IL1R1, IL6R, CSF1, KITLG, CD44",0.31069114087638,0.073657553374345,FALSE
+"H1975","Input","KEGG_HISTIDINE_METABOLISM",0.54462,1.71,0.0153,3072,0.387,"FTCD, ALDH3B1, ALDH9A1, ALDH3B2, HEMK1, MAOB, HNMT, METTL6, ALDH1B1, METTL2B",1.8153085691824,0.412289034981089,FALSE
+"H1975","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.53981,1.67,0.0306,3919,0.3,"POLD4, POLD2, NBN, RPA3, RAD51B, XRCC2, XRCC3, SSBP1, RAD51D, TOP3B, MRE11, TOP3A, RPA1",1.51427857351842,0.522878745280338,FALSE
+"H1975","Input","KEGG_HUNTINGTONS_DISEASE",0.37717,1.16,0.261,3032,0.611,"DNAH2, NDUFV1, CREB3L3, COX8C, DNAH3, UQCR11, NDUFS8, CREB3L1, UQCR10, HIP1, TBPL2, NDUFA7, ATP5F1B, GRIN1, NDUFB7, COX6B2, TP53, RCOR1, POLR2E, DNAH1, PPARG, DNAL1, POLR2J, IFT57, NDUFA6, SDHA, POLR2F, NDUFS2, CASP8, NDUFB2, NDUFS7, TGM2, NDUFA3, SDHC, UQCRC1, GPX1, ITPR1, ATP5F1D, SLC25A5, NDUFB6, AP2M1, NDUFA8, TFAM, POLR2H",0.583359492661719,0.213958789757446,FALSE
+"H1975","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.22257,-0.839,0.634,15780,0.986,"TNF, CACNG7, ITGA7, SGCD, ITGA9, CACNA2D3, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, TPM2, ITGA4, ATP2A2, PRKAG1, TNNC1, SLC8A1, DMD, CACNA2D1, ITGB8, PRKAA2, PRKAB1",0.197910742118267,0.0061230850587888,FALSE
+"H1975","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.23056,0.718,0.853,5131,0.967,"PTEN, PIP5K1C, IMPA2, IPMK, PIP4K2C, INPP5J, PIP4K2A, PI4KB, PIK3CA, CDIPT, INPP5K, PIK3C2A, PIK3CB, PLCG2, PIK3C3, PLCE1, SYNJ2",0.069050968832477,0.0145735259169983,FALSE
+"H1975","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.3059,0.968,0.496,4088,0.839,"GCK, PPP1CA, RPS6KB2, MAP2K2, PRKAR1B, CALM1, FBP1, ARAF, PYGL, PHKA1, CRK, INSR, ELK1, PRKAG2, SHC3, PPP1R3B, PRKAB2, PRKAA1, HK2, PPP1R3C, PRKACA, TRIP10, PIK3R2, SORBS1, PYGB, IRS1, PRKAR2A, MKNK2, PIK3CA, PHKB, PPP1CB, GSK3B, TSC1, PTPN1, INPP5K, MAPK1, RHEB, PIK3CB",0.304518323509803,0.0762380391712997,FALSE
+"H1975","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.20136,-0.737,0.82,14917,0.986,"TGFB1, CD86, ICOSLG, CCL27, IL5, CXCL12, TNFSF13B, TNFRSF13C, CXCR4, ITGA4",0.0861861476162833,0.0061230850587888,FALSE
+"H1975","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.21942,0.678,0.908,4091,0.969,"CRLF2, IL12B, EPOR, TYK2, CLCF1, IL7R, MYC, IL11, IL13RA1, IL24, OSMR, IL4R, IL15RA, PIAS4, STAM, PIAS2, PIAS3, PIK3R2, IL6R, LIFR, JAK3, STAT6, CTF1, PIK3CA, STAT5B, IRF9, PIK3CB, IFNGR1",0.0419141514789149,0.0136762229492347,FALSE
+"H1975","Input","KEGG_LEISHMANIA_INFECTION",0.22892,0.707,0.874,4133,0.944,"IL12B, C3, IRAK1, ELK1, ITGB2, IRAK4, MAPK12, TGFB2, TAB1, CYBA, MYD88, MAPK1, MAPK13, IFNGR1, TGFB3",0.058488567365597,0.025028005701931,FALSE
+"H1975","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19732,0.615,0.958,5361,0.978,"VAV1, RAC2, ARHGAP5, CLDN9, ACTN1, RAC1, ACTB, CLDN4, PRKCA, ITGB2, MYL9, MSN, MYL7, GNAI2, PIK3R2, ICAM1, MAPK12, CLDN23, CLDN7, PIK3CA, CYBA, MAPK13, BCAR1, RHOA, PIK3CB, F11R, VAV2, PLCG2, SIPA1, VCL, ROCK2, PTK2B, CLDN15, ITGB1, GNAI1, NCF2, CLDN22",0.0186344909214556,0.00966114521239857,FALSE
+"H1975","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.6488,2.02,0.00348,4373,0.451,"ALDH9A1, NAA80, ECHS1, ALDH1B1, HADHA, EHHADH",2.45842075605342,0.345823458122039,FALSE
+"H1975","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.46749,1.45,0.072,606,0.461,"CYP2C9, CYP2E1, CYP2C8, PLA2G2C",1.14266750356873,0.336299074610352,FALSE
+"H1975","Input","KEGG_LONG_TERM_DEPRESSION",0.23549,0.723,0.86,2875,0.976,"PPP2R1A, MAP2K2, PLA2G2C, GNA12, ARAF, CACNA1A, GNA11, LYN, PRKCA, ITPR1, GNAI2",0.0655015487564323,0.0105501823333082,FALSE
+"H1975","Input","KEGG_LONG_TERM_POTENTIATION",0.25539,0.782,0.783,2802,0.973,"PPP1CA, GRIN2A, MAP2K2, CALM1, RPS6KA3, GRIN1, ARAF, GRIN2D, RPS6KA2, PRKCA, ITPR1, PRKACA",0.106238237942057,0.0118871597316481,FALSE
+"H1975","Input","KEGG_LYSINE_DEGRADATION",0.29949,0.945,0.519,5620,0.839,"GCDH, ALDH9A1, AADAT, SUV39H1, ECHS1, ACAT1, PLOD2, SETMAR, ALDH1B1, HADHA, OGDH, KMT5C, EHHADH, KMT5B, SETD2, PLOD1, ASH1L, PLOD3, DLST",0.284832642151542,0.0762380391712997,FALSE
+"H1975","Input","KEGG_LYSOSOME",0.42113,1.32,0.115,4887,0.511,"AP3S1, ACP5, NPC1, ATP6V0D2, LIPA, NAGPA, AP1B1, CTNS, LGMN, GALC, ATP6V0D1, CTSA, ABCB9, AP1S1, IDS, CD68, DNASE2, AP3D1, PSAP, CTSG, SUMF1, CTSF, LAMP2, CTSD, TPP1, GALNS, CTSL, AP1M1, AP1S3, GBA, AP3B1, NPC2, AP4S1, NAPSA, HYAL1, MAN2B1, NAGLU, AGA, CTSS, CLTCL1, GLA, TCIRG1, CTSC, HEXB, CTSB, CLTC, AP1G1, NAGA, NEU1, CTSV, MCOLN1",0.939302159646388,0.291579099865287,FALSE
+"H1975","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.22854,0.712,0.89,4176,0.96,"ECSIT, MAP2K2, CACNG8, PLA2G2C, RAC2, MAPKAPK3, MAX, MYC, RPS6KA3, CDC25B, GNA12, CACNA1B, DUSP9, PPM1A, CACNA1A, PAK2, TP53, MECOM, RASA1, HSPB1, RAC1, MAP2K4, CRK, HSPA1A, MAP3K20, RPS6KA2, PRKCA, FLNA, ELK1, PAK1, IL1R1, GADD45B, MAP3K3, MAP2K7, HSPA2, PRKACA, RRAS2, DUSP10, MAP4K4, FGF1, MAPK12, MRAS, CHUK, MAPK8IP2, DUSP2, IKBKG, TGFB2, MKNK2, HSPA1B, HSPA8, PPP3CA, RPS6KA4, TAB1, FGF13, MAPK1, MAPK13, PLA2G12A, DUSP3, TGFB3, MAP3K6",0.0506099933550872,0.0177287669604316,FALSE
+"H1975","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.38632,1.21,0.193,11,0.591,"GCK",0.714442690992226,0.228412519118745,FALSE
+"H1975","Input","KEGG_MELANOGENESIS",-0.18683,-0.709,0.882,15583,0.936,"NRAS, WNT2B, EDNRB, FZD5, GNAI3, WNT7A, TYRP1, DVL3, WNT8B, FZD7, KIT, ADCY5, WNT6, CALML6, CAMK2B, WNT10A, WNT4, WNT11, WNT5A, HRAS, PRKACB, FZD8, FZD1, ADCY1, LEF1, PLCB4, WNT5B, KRAS, ADCY6, PLCB1",0.0545314148681803,0.0287241512618947,FALSE
+"H1975","Input","KEGG_MELANOMA",-0.27622,-1.03,0.375,14247,1,"PIK3R3, FGF19, FGF20, IGF1, CDKN1A, HGF, PIK3CG, FGF18, FGF9, FGF7, FGF21, NRAS, FGF14, CDK6, E2F3, PDGFD, PDGFRA, FGF17, FGF5, EGF, E2F2, PIK3CD, HRAS, FGF12, AKT3, PIK3R1, MDM2, KRAS, FGF2, RB1, AKT2",0.425968732272281,0,FALSE
+"H1975","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41512,1.3,0.13,1829,0.474,"CYP2C9, GSTT2, CYP2E1, ALDH3B1, CYP1B1, CYP2C8, GSTZ1, GSTO2, ALDH3B2, GSTK1",0.886056647693163,0.324221658325915,FALSE
+"H1975","Input","KEGG_MISMATCH_REPAIR",0.5466,1.7,0.0187,4075,0.356,"POLD4, POLD2, RPA3, PMS2, MLH1, SSBP1, RFC2, MSH6, EXO1, RPA1, PCNA",1.7281583934635,0.448550002027125,FALSE
+"H1975","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.25271,0.78,0.767,4088,0.96,"RPS6KB2, RPS6KA3, CAB39, HIF1A, MLST8, RPS6KA2, PRKAA1, RICTOR, PIK3R2, PIK3CA, STK11, TSC1, MAPK1, RHEB, PIK3CB",0.115204636051019,0.0177287669604316,FALSE
+"H1975","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.21448,0.667,0.918,4488,0.972,"VAV1, MAP2K2, RAC2, ARAF, KLRC1, RAC1, ICAM2, PRKCA, PAK1, ITGB2, SHC3, RAET1E, PIK3R2, ULBP3, RAET1L, ICAM1, PIK3CA, PPP3CA, NFATC3, SH3BP2, MAPK1, KIR2DL1, PIK3CB, IFNGR1, VAV2, PLCG2, RAET1G",0.0371573187987575,0.0123337350737254,FALSE
+"H1975","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.19263,0.6,0.977,2791,0.972,"GLP2R, P2RX6, GRIN2A, PTGER1, P2RX5, GIPR, GRIN1, CALCR, GABRD, TRPV1, P2RY6, F2RL1, FPR1, P2RY14, ADORA2B, EDNRA, ADORA2A, HRH1, GRIN2D, GABRB3, GRM6, NR3C1, CTSG, TBXA2R, P2RY2, MCHR1, F2R, LPAR2, TSPO",0.0101054362812269,0.0123337350737254,FALSE
+"H1975","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.25301,-0.903,0.563,17113,1,"FRS2, NFKBIA, IRAK3, CALML6, NTF3, TRAF6, CAMK2B, SHC2, CSK, PLCG1, NGFR, MAPK10, BCL2, PIK3CD, HRAS, TP73, MAP2K5, CAMK4, AKT3, PIK3R1, KRAS, ATF4, NFKBIB, NFKBIE, SORT1, AKT2, BEX3",0.249491605148654,0,FALSE
+"H1975","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.43901,1.35,0.121,4413,0.507,"NAMPT, NNMT, NT5C2, PNP, NT5M, AOX1, NMRK1, BST1, NT5E, NMNAT1",0.91721462968355,0.294992040666664,FALSE
+"H1975","Input","KEGG_NITROGEN_METABOLISM",0.31586,0.981,0.462,2132,0.825,"CA9, GLS, CA12, GLUD1",0.335358024443874,0.0835460514500749,FALSE
+"H1975","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23487,-0.901,0.53,15780,1,"TNF, BIRC2, TNFAIP3, SUGT1, NOD2, TAB2, IKBKB, MAPK11, MAP3K7, IL1B, NFKBIA, TRAF6, NLRP3, CXCL1, NLRC4, MAPK10, CXCL8, BIRC3, HSP90B1, NFKBIB",0.275724130399211,0,FALSE
+"H1975","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.34581,1.06,0.351,3926,0.738,"XRCC4, XRCC6, MRE11, NHEJ1",0.454692883534176,0.131943638176958,FALSE
+"H1975","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.33082,-1.21,0.209,17577,1,"EGF, PLCG1, E2F2, PIK3CD, HRAS, RARB, FHIT, AKT3, CASP9, PIK3R1, KRAS, RB1, AKT2",0.679853713888946,0,FALSE
+"H1975","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.19857,0.617,0.946,6732,0.983,"SNW1, DTX3L, APH1A, DVL2, LFNG, MFNG, PSEN1, NOTCH1, CTBP2, JAG1, PSEN2, DVL1, EP300, NUMB, NOTCH2, RBPJ, DTX3, NCSTN, HES1, KAT2A, MAML1",0.0241088635982073,0.00744648216786438,FALSE
+"H1975","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.3761,1.17,0.242,4644,0.597,"ERCC6, POLD4, RAD23A, CETN2, CUL4B, POLD2, RPA3, CDK7, RFC2, POLE3, CCNH, POLE2, RPA1, MNAT1, PCNA, RAD23B, POLE4, ERCC8",0.616184634019569,0.224025668870631,FALSE
+"H1975","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.2515,0.782,0.785,5039,0.973,"FUT8, ALG10, MGAT5B, RFT1, MGAT2, MAN1B1, ALG1, ALG10B, DPM2, STT3A, MGAT4B, DAD1, ST6GAL1, ALG2, TUSC3, ALG12",0.105130343254747,0.0118871597316481,FALSE
+"H1975","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.23366,-0.897,0.576,9443,1,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, CAMK2A, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR2AE1, OR5AK2, GUCA1A, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR2A7, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, PDC, OR2T4, OR2T6, OR1L6, OR13C4, ADCY3, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, CAMK2G, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR2A1, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR8B12, OR9A4, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, CALM3, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR51E2, OR11H6, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR13A1, OR5M11, OR13G1, OR2L13, OR5K1, OR1M1, OR51B2, OR52D1, OR51I1, OR1J1, OR5P3, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, CALM2, OR8D2, OR2T33, OR1J2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, CALML5, OR4D1, OR8G1, OR4F15, OR52B6, CALML3, OR2A25, OR2D3, OR1Q1, OR8A1, OR10A6, OR2A2, OR8G5, OR11H4, OR10A4, OR51B4, CLCA2, OR2D2, OR2AG1, OR10A3, OR10A2, OR2A14, OR4F17, OR2W3, OR6A2, OR56B4, OR1L8, OR2L2, PDE1C, CALML6, PRKG1, CAMK2B, GNAL, PRKG2, OR2AG2, PRKACB",0.239577516576788,0,FALSE
+"H1975","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.54479,1.69,0.0251,3558,0.298,"FTCD, MTHFD1, SHMT1, SHMT2, MTR",1.60032627851896,0.525783735923745,FALSE
+"H1975","Input","KEGG_OOCYTE_MEIOSIS",0.3253,1.02,0.421,5253,0.772,"SMC1B, PPP2R1A, PPP1CA, PPP2R5E, YWHAH, CALM1, RPS6KA3, ADCY7, CCNB1, CUL1, PLK1, YWHAQ, PPP2R5C, RPS6KA2, CDC20, ITPR1, ESPL1, PRKACA, SMC1A, MAPK12, BUB1, YWHAE, PPP1CB, PPP3CA, SPDYA, MAPK1, SLK, AURKA, CDC27, ITPR3, CDC25C, PKMYT1, ANAPC2, SMC3, CAMK2D, BTRC",0.375717904164332,0.112382699664264,FALSE
+"H1975","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.29778,0.931,0.553,4918,0.846,"GBA, MAN2B1, AGA, HEXB, NEU1, FUCA2, NEU3",0.257274868695302,0.0726296369609765,FALSE
+"H1975","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.34869,1.08,0.336,2987,0.717,"NDUFV1, COX8C, ATP6V0D2, UQCR11, NDUFS8, UQCR10, NDUFA7, ATP5F1B, LHPP, NDUFB7, COX6B2, ATP6V0D1, COX10, NDUFA11, NDUFA6, SDHA, NDUFS2, NDUFB2, NDUFS7, NDUFA3, COX15, SDHC, UQCRC1, ATP6V1D, ATP5F1D, ATP6V1F, NDUFB6, NDUFA8, ATP6V1E2",0.473660722610156,0.1444808443322,FALSE
+"H1975","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.55449,1.71,0.0163,3554,0.387,"GALNT15, GALNT9, GCNT1, GALNT6, GALNT10, GALNT12, GALNT18, GALNT2, C1GALT1, GALNT11, C1GALT1C1, B4GALT5, GALNT7, ST3GAL2",1.78781239559604,0.412289034981089,FALSE
+"H1975","Input","KEGG_P53_SIGNALING_PATHWAY",-0.23845,-0.913,0.532,16247,1,"MDM4, CDK6, CCNG1, RCHY1, APAF1, GADD45G, SESN3, CCND2, COP1, BID, GADD45A, ZMAT3, PIDD1, SESN2, BBC3, TP73, CASP9, CD82, SESN1, MDM2",0.274088367704952,0,FALSE
+"H1975","Input","KEGG_PANCREATIC_CANCER",-0.2403,-0.868,0.543,15778,1,"RAD51, VEGFD, CDC42, RAC3, BRCA2, CDK6, E2F3, IKBKB, EGF, E2F2, MAPK10, PIK3CD, ARHGEF6, AKT3, CASP9, PIK3R1, VEGFC, KRAS, RB1, AKT2",0.265200170411153,0,FALSE
+"H1975","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.33383,-1.29,0.127,15433,1,"PPCDC, PPCS, VNN2, VNN1, PANK4, PANK3",0.896196279044043,0,FALSE
+"H1975","Input","KEGG_PARKINSONS_DISEASE",0.2865,0.9,0.604,2969,0.867,"NDUFV1, COX8C, UQCR11, NDUFS8, UQCR10, NDUFA7, ATP5F1B, NDUFB7, COX6B2, PINK1, UBA7, NDUFA6, SDHA, NDUFS2, NDUFB2, NDUFS7, NDUFA3, SDHC, UQCRC1, ATP5F1D, SLC25A5, NDUFB6, UBE2L3, NDUFA8",0.218963061378868,0.0619809025237897,FALSE
+"H1975","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.38604,1.19,0.212,5708,0.604,"TLR5, TUBB3, ARPC1A, LY96, YWHAQ, ACTB, ARPC1B, TUBA4A, PRKCA, TUBB4B, TUBA1B, CDH1, WASL, TUBA1A, TUBA1C, RHOA, NCL, KRT18, ROCK2, ABL1, TUBB6, ITGB1, ARPC5L, ARPC4, CTTN, ACTG1",0.673664139071249,0.218963061378868,FALSE
+"H1975","Input","KEGG_PATHWAYS_IN_CANCER",0.19395,0.609,0.957,5225,0.974,"WNT9A, CSF1R, MAP2K2, FZD9, CCNA1, RAC2, EGLN3, MAX, MYC, BMP2, HSP90AA1, RALB, ARAF, PTEN, ITGA2B, LAMB3, TP53, MECOM, PPARD, DAPK3, FZD2, HIF1A, PPARG, TRAF3, EGLN1, RAC1, MLH1, CRK, FADD, NCOA4, RALA, DVL2, CASP8, PRKCA, PIAS4, MET, PIAS2, PIAS3, PIK3R2, TPM3, WNT7B, XIAP, LAMA3, MSH6, MITF, FGF1, APPL1, KITLG, CHUK, IKBKG, CKS1B, APC, TGFB2, CDH1, PIK3CA, EPAS1, RARA, GSK3B, BCR, STAT5B, RXRA, PTCH1, FGF13, CYCS, MAPK1, CTBP2, ITGA3, RHOA, PIK3CB, CDKN2B, TGFB3, FN1, DAPK1, GSTP1, FZD4, ETS1, PLCG2, BMP4, EGFR, RALBP1, RUNX1, ABL1, LAMB2, FH, SMAD4, ITGA2, RALGDS, LAMC2, BRAF, DVL1, CBLC, LAMC1, GLI3, ITGB1, EP300",0.0190880622231565,0.0114410431213845,FALSE
+"H1975","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39142,1.24,0.163,2379,0.534,"RPEL1, XYLB, AKR1B1, DHDH",0.787812395596042,0.272458742971444,FALSE
+"H1975","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.48807,1.5,0.0629,1867,0.451,"ALDOA, PRPS2, FBP1, RBKS, PGLS, RPEL1, ALDOC, PRPS1",1.20134935455473,0.345823458122039,FALSE
+"H1975","Input","KEGG_PEROXISOME",0.25755,0.791,0.757,4950,0.974,"ACOX2, HACL1, ACSL4, PEX11G, PMVK, PEX19, DHRS4, ACAA1, PEX26, GSTK1, ACSL5, PEX11B, PXMP4, PAOX, DECR2, SLC25A17, CAT, PEX3, AGPS, AMACR, FAR1, EHHADH, CROT, CRAT, EPHX2, PEX2",0.120904120499927,0.0114410431213845,FALSE
+"H1975","Input","KEGG_PHENYLALANINE_METABOLISM",0.58904,1.86,0.0116,2497,0.586,"ALDH3B1, AOC2, NAA80, ALDH3B2, AOC3, MIF, MAOB, GOT2",1.93554201077308,0.232102383981909,FALSE
+"H1975","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.2887,0.893,0.605,5637,0.874,"DGKI, CALM1, CDS2, PTEN, PIP5K1C, DGKD, IMPA2, DGKG, PRKCA, PIP4K2C, INPP5J, PIP4K2A, ITPR1, PIK3R2, PI4KB, PIK3CA, CDIPT, INPP5K, PIK3C2A, PIK3CB, PLCG2, DGKE, PIK3C3, ITPR3, PLCE1, SYNJ2, DGKA, DGKZ, PI4KA",0.218244625347531,0.058488567365597,FALSE
+"H1975","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.44685,1.4,0.0862,5437,0.468,"HMOX1, COX10, HMOX2, UROS, COX15, EARS2, CPOX, ALAD, HCCS, PPOX, HMBS, BLVRA, FTH1, UROD",1.06449273417529,0.329754146925876,FALSE
+"H1975","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.30184,0.956,0.502,4836,0.831,"ACOX2, PLTP, ACSL4, SLC27A5, SLC27A4, ANGPTL4, PPARD, ACAA1, PPARG, ACSL5, FABP5, SORBS1, CPT1C, RXRA, NR1H3, GK, SCD, EHHADH, CYP27A1, PDPK1",0.299296282854981,0.080398976215889,FALSE
+"H1975","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45483,1.42,0.0739,995,0.464,"ACOX2, HSD3B7, SLC27A5",1.13135556160517,0.333482019445119,FALSE
+"H1975","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.386,1.2,0.207,5218,0.592,"CD79A, CD19, IL7R, CIITA, CD40, JAK3, IKBKG, ADA, TAP2, RFXANK, RFX5, LCK",0.684029654543082,0.22767829327708,FALSE
+"H1975","Input","KEGG_PRION_DISEASES",0.23302,0.718,0.851,3888,0.967,"MAP2K2, HSPA1A, ELK1, PRKACA, NOTCH1, PRNP, MAPK1",0.0700704399154121,0.0145735259169983,FALSE
+"H1975","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21291,-0.816,0.691,17438,0.985,"CDC16, CPEB1, MAPK10, PIK3CD, PRKACB, ADCY1, ANAPC7, AKT3, ANAPC13, PDE3B, PIK3R1, ANAPC10, KRAS, ADCY6, AKT2",0.160521952625802,0.00656376950238827,FALSE
+"H1975","Input","KEGG_PROPANOATE_METABOLISM",0.41945,1.31,0.125,4878,0.504,"LDHC, LDHA, ALDH9A1, ECHS1, ACAT1, LDHAL6B, ALDH1B1, HADHA, PCCB, EHHADH, ACACA, SUCLG1",0.903089986991944,0.297569463554475,FALSE
+"H1975","Input","KEGG_PROSTATE_CANCER",-0.281,-0.992,0.456,16569,1,"E2F3, IKBKB, PDGFD, PDGFRA, NFKBIA, AR, FOXO1, EGF, E2F2, BCL2, PIK3CD, HRAS, FGFR2, AKT3, CASP9, LEF1, PIK3R1, MDM2, KRAS, HSP90B1, ATF4, RB1, AKT2",0.341035157335565,0,FALSE
+"H1975","Input","KEGG_PROTEASOME",0.40843,1.26,0.161,5843,0.5,"PSMC1, PSMF1, PSMA3, PSMC2, PSMB9, PSMD11, PSMD4, PSMD2, PSMB6, PSMA2, PSMB4, PSMD7, PSMB8, PSMD6, PSMD12, PSMB7, PSMD1, PSME1, PSMC5, SEM1, PSMB5, PSME2, PSME3, PSME4",0.79317412396815,0.301029995663981,FALSE
+"H1975","Input","KEGG_PROTEIN_EXPORT",-0.44499,-1.64,0.0465,15662,1,"SPCS3, SEC62, SEC11A, IMMP1L, SEC63, SRP14, SEC11C, IMMP2L, SPCS2",1.33254704711005,0,FALSE
+"H1975","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23675,-0.92,0.537,14779,1,"ATP1B2, MDH1, ATP1A1, FXYD2, SLC38A3, GLS2, CA2, ATP1B1, ATP1A3, PCK2",0.270025714300444,0,FALSE
+"H1975","Input","KEGG_PURINE_METABOLISM",0.32959,1.03,0.378,5239,0.755,"POLD4, IMPDH2, NME5, GUCY2D, PRPS2, HPRT1, PDE4A, POLD2, APRT, IMPDH1, ADCY7, AK4, AK7, POLR2E, PDE2A, NME7, PAPSS2, PFAS, ADK, PRPS1, POLR3H, POLR2J, AK1, NT5C2, PNP, POLR2F, GUK1, POLR3G, PRIM1, NT5M, POLR3A, NME2, PDE5A, ITPA, POLR2H, POLR3GL, POLE3, RRM2, POLE2, ENTPD5, ADSL, ADA, POLR1C, NT5E, NME3, NME6, POLR1E, POLE4, PDE6D, POLR1A, PKM, GMPR2, POLR3C, NPR1, NME1, ENTPD6, ENTPD3",0.422508200162775,0.122053048370812,FALSE
+"H1975","Input","KEGG_PYRIMIDINE_METABOLISM",0.41103,1.28,0.135,5239,0.48,"POLD4, CDA, NME5, UPP1, POLD2, POLR2E, NME7, POLR3H, POLR2J, NT5C2, PNP, POLR2F, UMPS, UPRT, CMPK2, POLR3G, TYMP, PRIM1, NT5M, UCK2, POLR3A, NME2, ITPA, POLR2H, DHODH, TK2, POLR3GL, POLE3, RRM2, POLE2, ENTPD5, POLR1C, NT5E, NME3, NME6, POLR1E, POLE4, POLR1A, CAD, POLR3C, DTYMK, NME1, ENTPD6, ENTPD3",0.869666231504994,0.318758762624413,FALSE
+"H1975","Input","KEGG_PYRUVATE_METABOLISM",0.51518,1.63,0.0319,3486,0.337,"LDHC, PC, LDHD, LDHA, ALDH9A1, MDH2, DLD, AKR1B1, PDHA1, ACAT1, LDHAL6B, ALDH1B1, ME3, HAGHL, PDHB",1.49620931694282,0.472370099128661,FALSE
+"H1975","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.27955,0.879,0.63,5366,0.88,"PPP1CA, VAV1, MAP2K2, MYLK2, LIMK1, PAK6, RAC2, GNA12, ARAF, ITGA5, ITGA2B, PAK2, ARPC1A, PIP5K1C, ITGB3, ACTN1, MYLK, RAC1, ACTB, CRK, ARPC1B, PIP4K2C, PAK1, ENAH, ITGB2, F2R, DIAPH1, TMSB4X, DIAPH2, IQGAP3, MYH9, MYL9, SSH3, MSN, PIP4K2A, ITGAE, RRAS2, MYL7, PIK3R2, FGF1, FGD1, MRAS, SSH2, CFL2, APC, TIAM1, PIK3CA, PPP1CB, WASL, FGF13, MAPK1, BCAR1, ITGA3, RHOA, PIK3CB, FN1, MYH10, VAV2, VCL, EGFR, ROCK2, IQGAP1, ITGA2, BRAF, DOCK1, GNA13, ITGB1, ITGAX, TIAM2, ARPC5L, ARPC4",0.200659450546418,0.0555173278498314,FALSE
+"H1975","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.22708,0.712,0.876,5419,0.96,"ATG7, ATG12, ATG4A, PIK3R4, PRKAA1, GABARAP, ATG3, PIK3C3, BECN1, ULK2",0.0574958938319193,0.0177287669604316,FALSE
+"H1975","Input","KEGG_RENAL_CELL_CARCINOMA",0.26049,0.817,0.741,4320,0.941,"MAP2K2, PAK6, EGLN3, ARAF, PAK2, HIF1A, FLCN, EGLN1, RAC1, CRK, PAK1, MET, PIK3R2, TGFB2, PIK3CA, EPAS1, MAPK1, PIK3CB, TGFB3, ETS1",0.130181792020672,0.0264103765727431,FALSE
+"H1975","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.5803,1.8,0.00946,1975,0.55,"ANPEP, THOP1, AGT, CTSA, NLN, CTSG",2.02410886359821,0.259637310505756,FALSE
+"H1975","Input","KEGG_RETINOL_METABOLISM",0.30349,0.951,0.513,2503,0.834,"CYP2C9, CYP2C8, AWAT2, RDH11, DHRS4, CYP26B1, RETSAT, DHRS4L2",0.289882634888184,0.0788339493622613,FALSE
+"H1975","Input","KEGG_RIBOFLAVIN_METABOLISM",0.42251,1.32,0.132,2422,0.511,"ACP5, ACP6, FLAD1",0.87942606879415,0.291579099865287,FALSE
+"H1975","Input","KEGG_RIBOSOME",-0.18877,-0.688,0.9,16443,0.92,"RPS20, RPLP0, RPL9, RPL11, RPL6, RPS6, RSL24D1, RPL18, RPS27A, RPS8, RPL4, RPS4Y1, RPL21, RPL13A, RPS11, RPS16, RPS19",0.0457574905606751,0.0362121726544447,FALSE
+"H1975","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.36806,1.14,0.249,4513,0.638,"IL12B, MAVS, TRIM25, PIN1, ATG12, CYLD, TRAF3, FADD, ISG15, TRADD, CASP8, CASP10, DDX58, DHX58, RNF125, MAPK12, CHUK, IKBKG, MAPK13, TBKBP1, AZI2, DDX3X, NLRX1, RIPK1",0.603800652904264,0.195179321278838,FALSE
+"H1975","Input","KEGG_RNA_DEGRADATION",0.31907,0.984,0.463,7135,0.839,"LSM7, CNOT3, PAPOLA, LSM5, EDC4, CNOT4, HSPD1, MPHOSPH6, CNOT10, CNOT7, ENO1, XRN2, EXOSC7, CNOT6, PARN, EXOSC2, EXOSC3, SKIV2L, TTC37, LSM8, ENO2, EXOSC5, PATL1, LSM3, CNOT1, HSPA9, LSM4, EXOSC1, DCP1A, CNOT6L, ZCCHC7, PAPOLB",0.334419008982047,0.0762380391712997,FALSE
+"H1975","Input","KEGG_RNA_POLYMERASE",0.33649,1.05,0.371,4966,0.754,"POLR2E, POLR3H, POLR2J, POLR2F, POLR3G, POLR3A, POLR2H, POLR3GL, POLR1C, POLR1E, POLR1A, POLR3C",0.430626090384954,0.122628654130226,FALSE
+"H1975","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.31331,0.96,0.495,4567,0.83,"PAPSS2, HEMK1, AHCY, METTL6, METTL2B, SEPHS1, SCLY, GGT7",0.305394801066431,0.0809219076239261,FALSE
+"H1975","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.32651,-1.23,0.167,16569,1,"E2F3, IKBKB, APAF1, PTGS2, PIAS1, LAMA5, COL4A4, NFKBIA, TRAF6, LAMA2, LAMC3, LAMA1, E2F2, BCL2, PIK3CD, RARB, FHIT, PTK2, AKT3, LAMA4, CASP9, BIRC3, PIK3R1, COL4A1, RB1, COL4A2, LAMB1, AKT2",0.777283528852417,0,FALSE
+"H1975","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.42031,1.31,0.121,4374,0.504,"VTI1B, STX10, USE1, STX8, VTI1A, VAMP7, YKT6, SNAP47, VAMP8, STX4, SNAP29, STX1A, SNAP23, STX3, STX1B",0.91721462968355,0.297569463554475,FALSE
+"H1975","Input","KEGG_SPHINGOLIPID_METABOLISM",0.35951,1.13,0.271,7055,0.652,"SPTLC2, GALC, SGPP1, SPHK1, PLPP2, SGMS2, SGMS1, GBA, GLA, SMPD4, UGCG, NEU1, NEU3, KDSR, PLPP3, B4GALT6, ASAH2, SPTLC1, SGPL1, SMPD1, ARSA",0.567030709125594,0.18575240426808,FALSE
+"H1975","Input","KEGG_SPLICEOSOME",0.33022,1.03,0.389,5449,0.755,"PRPF31, SNW1, CTNNBL1, LSM7, RBM8A, ISY1, PQBP1, PRPF8, DHX38, HNRNPM, SNU13, HSPA1A, LSM5, PLRG1, U2AF2, SNRPB, RBM25, SRSF6, NCBP1, HSPA2, SF3B3, EFTUD2, CRNKL1, PRPF4, U2SURP, HSPA1B, HSPA8, BUD31, PPIL1, SLU7, DDX46, PRPF19, SNRPB2, SF3B4, SRSF1, SRSF5, SMNDC1, PRPF3, SF3A2, HNRNPK, XAB2, LSM8, PRPF6, SNRPD3",0.410050398674292,0.122053048370812,FALSE
+"H1975","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.38786,1.2,0.199,4362,0.592,"GCK, PGM2L1, PYGL, HK2, PYGB, GBE1, PGM2, UGDH, HK1",0.701146923590293,0.22767829327708,FALSE
+"H1975","Input","KEGG_STEROID_BIOSYNTHESIS",0.35022,1.09,0.321,1600,0.7,"LIPA, SOAT1, NSDHL",0.493494967595128,0.154901959985743,FALSE
+"H1975","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.29429,0.911,0.572,1748,0.867,"CYP11B1, CYP1B1, HSD17B6, STS",0.242603971206976,0.0619809025237897,FALSE
+"H1975","Input","KEGG_SULFUR_METABOLISM",0.30808,0.966,0.485,5223,0.835,"SULT1A4, PAPSS2, CHST11, SUOX, CHST12, SULT2B1, BPNT1",0.314258261397736,0.0783135245163979,FALSE
+"H1975","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.37457,1.18,0.229,3754,0.606,"GRIN2A, C4B, C4A, C3, ACTN1, CTSG, CD40, SNRPB, TRIM21, C1R",0.640164517660112,0.217527375833714,FALSE
+"H1975","Input","KEGG_TASTE_TRANSDUCTION",-0.1951,-0.755,0.79,12258,1,"TAS2R41, TAS2R8, PLCB2, PRKACG, GRM4, TAS1R2, TAS2R20, SCNN1A, ADCY8, TAS2R39, SCNN1G, GNAS, SCNN1B, TAS2R3, TAS2R38, TAS2R1, ASIC2, ADCY4, PDE1A, TAS2R46, TAS2R31, TAS2R10, TAS2R43, PRKACB, GNB1, ADCY6",0.102372908709559,0,FALSE
+"H1975","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.28783,-1.09,0.321,13732,1,"BAAT, GGT5, GGT6, CDO1",0.493494967595128,0,FALSE
+"H1975","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.31798,0.987,0.459,2018,0.841,"PMVK, ACAT1",0.338187314462739,0.0752040042020878,FALSE
+"H1975","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28547,0.888,0.599,6241,0.877,"PPP2R1A, RPS6KB2, THBS3, AMH, SMURF1, NOG, MYC, BMP2, CUL1, RBL1, TGFB2, LTBP1, MAPK1, RHOA, E2F4, CDKN2B, TGFB3, BMPR1B, BMP4, ID4, ROCK2, SMAD4, BMPR2, EP300, SMAD3, SKP1, TGFBR1, ACVR2B, THBS1, BMPR1A, PPP2R1B, TGFBR2, ACVR1",0.222573177610689,0.0570004066339595,FALSE
+"H1975","Input","KEGG_THYROID_CANCER",0.35496,1.11,0.286,3888,0.681,"MAP2K2, MYC, TP53, PPARG, NCOA4, TPM3, CDH1, RXRA, MAPK1",0.543633966870957,0.166852888087215,FALSE
+"H1975","Input","KEGG_TIGHT_JUNCTION",-0.18358,-0.692,0.909,16463,0.937,"EPB41, SYMPK, ACTN2, VAPA, IGSF5, MAGI2, CSNK2B, PARD6B, HCLS1, JAM2, PPP2CA, PPP2R2B, PRKCQ, EPB41L3, HRAS, PPP2R2C, MYL12B, AMOTL1, JAM3, RAB3B, AKT3, PARD6A, CLDN1, KRAS, MPDZ, AKT2",0.0414361167780325,0.0282604091122217,FALSE
+"H1975","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.27278,0.859,0.66,4088,0.889,"IL12B, TLR5, MAP2K2, TICAM2, LY96, TRAF3, RAC1, MAP2K4, FADD, IRAK1, IRF5, CASP8, CD40, MAP2K7, IRAK4, PIK3R2, MAPK12, CHUK, IKBKG, PIK3CA, TAB1, MYD88, MAPK1, MAPK13, TICAM1, PIK3CB",0.180456064458131,0.0510982390297863,FALSE
+"H1975","Input","KEGG_TRYPTOPHAN_METABOLISM",0.43105,1.34,0.12,4414,0.513,"GCDH, CYP1B1, ALDH9A1, AADAT, ECHS1, ACAT1, MAOB, ALDH1B1, HADHA, AOX1, OGDH, CAT, MAOA, EHHADH, KYNU",0.920818753952375,0.289882634888184,FALSE
+"H1975","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29726,0.915,0.581,4362,0.876,"GCK, CACNA1B, CACNA1A, INSR, HK2, PIK3R2, IRS1, PIK3CA, MAPK1, PRKCD, PIK3CB, HK1",0.235823867609669,0.0574958938319193,FALSE
+"H1975","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.23394,0.723,0.846,112,0.976,"IL12B",0.0726296369609765,0.0105501823333082,FALSE
+"H1975","Input","KEGG_TYROSINE_METABOLISM",0.44898,1.42,0.0792,3072,0.464,"ALDH3B1, GSTZ1, AOC2, NAA80, ALDH3B2, AOC3, MIF, HEMK1, MAOB, METTL6, GOT2, AOX1, METTL2B",1.10127481841051,0.333482019445119,FALSE
+"H1975","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17955,-0.625,0.923,15555,0.96,"FYN, NRAS, PAK3, TNF, CDC42, IL5, PPP3R1, IKBKB, MAPK11, CD4, MAP3K7, NFKBIA, PLCG1, NCK2, PRKCQ, PIK3CD, HRAS, AKT3, PIK3R1, PAK4, KRAS, NFKBIB, NFKBIE, AKT2",0.0347982989740879,0.0177287669604316,FALSE
+"H1975","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.25737,0.809,0.731,6465,0.948,"UBA6, KEAP1, CUL4B, SMURF1, FZR1, PPIL2, HUWE1, STUB1, UBE2D1, UBA7, CUL1, FBXO2, UBE2F, BRCA1, UBE2S, UBE2D4, WWP2, PIAS4, TRIM37, CDC20, UBE2M, HERC4, PIAS2, PIAS3, UBE2L3, XIAP, UBE2C, ITCH, UBE2H, NHLRC1, UBE3C, MID1, PRPF19, UBE2E3, UBE2O, UBA1, UBE2Q1, CDC27, ERCC8, UBE2L6, ANAPC2, CBLC, BTRC, CUL7, CDC34, FBXO4, TRIM32, ANAPC1, UBE2K, SKP1, SIAH1, TRIP12, SOCS3, NEDD4L, MGRN1, BIRC6, UBE4A, UBE2I, CDC26, UBE2G1, CDC23",0.13608262304214,0.0231916626619338,FALSE
+"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.56066,1.75,0.0211,3486,0.544,"LARS2, IARS2, PDHA1, PDHB",1.67571754470231,0.26440110030182,FALSE
+"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.45051,1.43,0.0725,4656,0.483,"ALDH9A1, HIBADH, ACAA1, DLD, ECHS1, ACAT1, ALDH1B1, HADHA, AOX1, IVD, OXCT1, HSD17B10, PCCB, ACADSB, EHHADH, MCCC2, ACAA2",1.13966199342901,0.316052869248488,FALSE
+"H1975","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.23538,0.73,0.874,4060,0.982,"PPP1CA, RAMP1, MAP2K2, MYLK2, PLA2G2C, CALM1, GNA12, ARAF, ADCY7, GNA11, ADORA2B, EDNRA, ADORA2A, MYLK, PRKCA, MYL9, ITPR1, PRKACA, PPP1CB, CALD1, MYL6, MAPK1, PRKCD, PLA2G12A, RHOA",0.058488567365597,0.00788851221305034,FALSE
+"H1975","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.3188,1,0.43,6423,0.815,"CREB3L3, CREB3L1, DYNC1H1, RAB11B, DYNC2H1, DYNLL2, PRKACA, CREB5, STX4, DCTN2, CREB3L2, CREB3L4, NSF, CREB1, DYNC1LI1, DYNC1I2, RAB5C, DCTN1, RAB5B, PRKX, ADCY9",0.366531544420413,0.0888423912600234,FALSE
+"H1975","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23242,0.737,0.844,4088,0.98,"NOS3, MAP2K2, PLA2G2C, RAC2, MAPKAPK3, HSPB1, RAC1, SPHK1, PRKCA, PIK3R2, MAPK12, PIK3CA, PPP3CA, NFATC3, MAPK1, MAPK13, PLA2G12A, PIK3CB",0.073657553374345,0.00877392430750515,FALSE
+"H1975","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.27487,0.851,0.669,6423,0.897,"ATP6V0D2, ERO1A, ATP6V0D1, TJP2, ACTB, PRKCA, ATP6V1D, PRKACA, ATP6V1F, ATP6V1E2, TCIRG1, ATP6V0E2, PLCG2, KDELR3, SEC61G, ARF1, ATP6V1E1, SEC61A1, TJP1, ATP6V0E1, ACTG1, PDIA4, ATP6V1C1, ATP6V1B2, PRKX, KDELR2, ADCY9",0.174573882232177,0.0472075569559079,FALSE
+"H1975","Input","KEGG_VIRAL_MYOCARDITIS",0.32969,1.03,0.413,4251,0.755,"MYH15, RAC2, RAC1, ACTB, ABL2, CASP8, CD40, ITGB2, CAV1, MYH9, EIF4G1, ICAM1, CYCS, DAG1, MYH10",0.384049948343599,0.122053048370812,FALSE
+"H1975","Input","KEGG_WNT_SIGNALING_PATHWAY",0.20679,0.653,0.934,4060,0.978,"WNT9A, PPP2R1A, PPP2R5E, PRICKLE2, FZD9, RAC2, MYC, DAAM1, TP53, PPARD, FZD2, CUL1, PRICKLE1, TBL1X, RAC1, PPP2R5C, DVL2, PRKCA, RUVBL1, PRKACA, PSEN1, WNT7B, APC, PPP3CA, GSK3B, NFATC3, CTBP2, FOSL1, DKK1, RHOA",0.0296531237699066,0.00966114521239857,FALSE
+"H1648","Input","KEGG_ABC_TRANSPORTERS",0.39832,1.18,0.211,4466,0.672,"ABCC5, ABCA12, ABCC2, ABCB9, ABCA7, ABCA13, ABCC3, ABCB6, ABCD1, TAP2, ABCA1, ABCB11, ABCC1, ABCG1",0.675717544702307,0.172630726946175,FALSE
+"H1648","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.38703,1.15,0.24,5702,0.673,"IKBKB, PML, JUP, BRAF, PIK3CB, RUNX1, EIF4EBP1, MAP2K1, RPS6KB2, BAD, NFKB1, PIK3CA, MYC, MTOR, IKBKG, PIM1, STAT5A, CEBPA, RELA, RAF1, STAT5B, TCF7, CCND1, MAP2K2",0.619788758288394,0.171984935776023,FALSE
+"H1648","Input","KEGG_ADHERENS_JUNCTION",-0.25687,-0.907,0.567,17254,0.803,"FER, RHOA, CTNNA1, SSX2IP, TCF7L1, PTPRM, FYN, WASF3, NECTIN3, TGFBR1, FGFR1, WASF2, CDC42, SMAD2",0.246416941107093,0.095284454721319,FALSE
+"H1648","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.30752,0.924,0.564,5333,1,"NFKBIA, IKBKB, TRADD, NFKBIE, MAPK9, ACSL5, TRAF2, TNFRSF1B, MAPK10, TNF, NFKB1, CAMKK1, STK11, RXRA, MTOR, IKBKG, RELA, IRS1, PRKAB1, CPT1C, CAMKK2, CPT1A, ACSL1",0.248720896016658,0,FALSE
+"H1648","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39667,1.21,0.197,4648,0.645,"IL4I1, NIT2, GLUD1, GAD1, ASL, DDO, ACY3, GLUL, ASS1, CAD, GLS2",0.705533773838407,0.190440285364732,FALSE
+"H1648","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.42261,1.26,0.157,5399,0.571,"SCNN1G, SCNN1B, SCNN1A, PIK3CB, SLC9A3R2, SFN, PIK3CA, HSD11B1, HSD11B2, INSR, ATP1B3, IRS1, ATP1A3, ATP1B1",0.804100347590766,0.243363891754152,FALSE
+"H1648","Input","KEGG_ALLOGRAFT_REJECTION",0.27671,0.835,0.713,2957,1,"CD40, TNF",0.146910470148134,0,FALSE
+"H1648","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.37999,1.14,0.25,5121,0.675,"PLA2G4E, PLA2G4B, PLA2G10, PLA2G12A, PLA2G2F, ACOX1",0.602059991327962,0.170696227168975,FALSE
+"H1648","Input","KEGG_ALZHEIMERS_DISEASE",-0.25911,-0.923,0.504,17647,0.788,"UQCRQ, ITPR2, NDUFB3, PLCB4, COX7A2, ATF6, NDUFA8, NDUFA7, NDUFA4, NDUFS4, GNAQ, CALM3, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APBB1, APAF1, COX6B1, PPP3CB, BACE1, NDUFB2, SDHC, PPP3R1, ATP5MC2, NDUFS5",0.297569463554475,0.103473782510445,FALSE
+"H1648","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.33516,-1.17,0.261,16304,0.673,"VARS2, IARS2, NARS2, SARS2, WARS2, PSTK, RARS2, FARS2",0.583359492661719,0.171984935776023,FALSE
+"H1648","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.22266,-0.85,0.656,16450,0.863,"PMM2, NANP, GMPPA, NANS, PMM1, CYB5R3, GNPDA2, GFPT1, UGP2, UAP1",0.18309616062434,0.0639892042847904,FALSE
+"H1648","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.2113,-0.802,0.807,18004,0.851,"BCL2, ALS2, MAP2K6, MAPK14, APAF1, PPP3CB, PPP3R1",0.0931264652779296,0.0700704399154121,FALSE
+"H1648","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32656,0.984,0.472,5251,0.942,"PSME2, CD74, CTSS, PSME1, CIITA, CANX, IFI30, B2M, TAP2, HSPA1B, HSPA1A, LGMN, TAPBP, PSME3, HSPA4, CTSB, TAP1",0.326058001365912,0.0259490972071227,FALSE
+"H1648","Input","KEGG_APOPTOSIS",0.36086,1.1,0.307,4360,0.716,"NFKBIA, IRAK2, BIRC3, IKBKB, IL1A, TRADD, DFFA, CAPN1, PIK3CB, TNFRSF10A, CHP2, TRAF2, IRAK1, MAP3K14, BAD, TNF, MYD88, NFKB1, IL1R1, PRKAR1B, PIK3CA, TNFSF10, TNFRSF10D, TNFRSF10C, CYCS, IKBKG, CFLAR, TNFRSF10B",0.512861624522813,0.145086977692144,FALSE
+"H1648","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.54704,1.66,0.021,4164,0.573,"CYP4F3, PLA2G4E, CYP2E1, GPX2, GGT6, CYP2J2, PTGS1, AKR1C3, LTC4S, GGT1, GPX3, PLA2G4B, PLA2G10, CYP2C18, LTA4H, GGT7, PTGES2, ALOX12B, EPHX2, CBR3, CBR1, PLA2G12A",1.67778070526608,0.24184537803261,FALSE
+"H1648","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.33383,1,0.461,4888,0.918,"PYCR3, AMD1, CKMT1A, CKMT1B, SAT1, GLUD1, AZIN2, ASL, NOS3, PRODH, GLUL, OAT, MAOA, AOC1, ASS1, GLS2, ALDH3A2, NAGS",0.336299074610352,0.0371573187987575,FALSE
+"H1648","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.25143,0.766,0.817,3332,1,"ITGB6, CACNB1, ITGA2, JUP, ITGB4, ITGB8, DSC2, LAMA2, PKP2, CACNA1F, CACNB4, DSP, ITGAV, DSG2",0.0877779434675845,0,FALSE
+"H1648","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32225,-1.14,0.218,18443,0.625,"ALDH1B1, ALDH9A1",0.661543506395395,0.204119982655925,FALSE
+"H1648","Input","KEGG_ASTHMA",0.29661,0.902,0.606,2957,1,"CD40, TNF",0.217527375833714,0,FALSE
+"H1648","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.24092,0.723,0.88,1371,1,"CD40, TSHB",0.0555173278498314,0,FALSE
+"H1648","Input","KEGG_AXON_GUIDANCE",0.26975,0.813,0.748,3063,1,"RND1, PLXNA1, NCK1, MET, SEMA4A, NFATC4, PAK6, SEMA7A, SRGAP3, EPHB3, SEMA4B, EPHA1, PLXNB3, PAK2, RAC2, CHP2, PLXNA2, UNC5A, SEMA3B, EPHA2, PLXNB1, PAK1, ABLIM3, RHOD, EFNA1, LIMK2, PTK2, PLXNB2",0.126098402135539,0,FALSE
+"H1648","Input","KEGG_BASAL_CELL_CARCINOMA",0.23492,0.707,0.882,2540,1,"WNT9A, DVL1, DVL3, WNT7A, WNT10A, BMP2, FZD5",0.0545314148681803,0,FALSE
+"H1648","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.3335,-1.14,0.265,17073,0.625,"GTF2B, GTF2A1, TAF9, STON1, TAF1, TAF11, TAF9B, TAF12",0.576754126063192,0.204119982655925,FALSE
+"H1648","Input","KEGG_BASE_EXCISION_REPAIR",0.4702,1.42,0.0763,5907,0.487,"MUTYH, POLB, NEIL1, MBD4, POLL, PARP3, POLD4, SMUG1, PARP2, POLE2, UNG, POLE, APEX1, OGG1",1.11747546204512,0.312471038785366,FALSE
+"H1648","Input","KEGG_BETA_ALANINE_METABOLISM",-0.36707,-1.34,0.117,18214,0.659,"HIBCH, SMS, ACADM, ALDH1B1, ALDH9A1",0.931814138253838,0.18111458540599,FALSE
+"H1648","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.32236,-1.23,0.159,17624,0.734,"ELOVL2, FADS2, ACOT7, HACD1",0.798602875679548,0.134303940083929,FALSE
+"H1648","Input","KEGG_BLADDER_CANCER",0.45711,1.37,0.0917,1484,0.521,"MMP9, FGFR3, E2F1, CXCL8, MMP1, CDH1, EGF, VEGFC, BRAF",1.03763066432998,0.283162276700476,FALSE
+"H1648","Input","KEGG_BUTANOATE_METABOLISM",0.24511,0.729,0.851,2914,1,"AKR1B10, BDH1, L2HGDH, GAD1, AACS",0.0700704399154121,0,FALSE
+"H1648","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39009,1.18,0.227,4804,0.672,"NFKBIA, CARD11, IKBKB, DAPP1, LYN, PLCG2, NFATC4, NFKBIE, PIK3CB, RAC2, PTPN6, CHP2, PIK3AP1, MAP2K1, VAV1, SYK, NFKB1, PIK3CA, BLNK, BCL10, IKBKG, NFATC2, VAV3, RAC1, RELA, NFAT5, CD72",0.643974142806877,0.172630726946175,FALSE
+"H1648","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.27697,0.821,0.721,3884,1,"DRD5, HTR7, LTB4R2, VDAC3, GNA15, PTAFR, P2RX5, PLCG2, ADRA1B, ADRB2, CALML6, GRIN2D, RYR3, ADCY4, CHP2, PLCB3, GRIN1, CHRM3, PTK2B, ADORA2A, P2RX6, SLC25A5, NOS3, CACNA1F, SLC25A31, ADCY3, SPHK1, CALML5, ERBB3, PHKG2, P2RX4, ATP2A2, ITPR3",0.142064735280571,0,FALSE
+"H1648","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.20876,0.626,0.958,2974,1,"UQCRFS1, COX6B2, CACNB1, TNNI3, COX5A, CYC1, UQCRHL, CACNA1F, CACNB4, UQCRB",0.0186344909214556,0,FALSE
+"H1648","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.42651,1.28,0.154,2286,0.601,"CLDN18, CD6, ITGAM, CLDN9, SELL, SELP, CLDN10, CLDN8, NECTIN1, ICOSLG, CDH3, CLDN20, CD40, ITGB2, CDH1, CLDN7, CLDN3, ITGB8, CLDN23, CLDN4, NRCAM, ICAM2, CLDN1, OCLN, SDC1",0.812479279163537,0.22112552799726,FALSE
+"H1648","Input","KEGG_CELL_CYCLE",-0.28219,-1.03,0.397,16874,0.791,"MAD2L2, CDC23, CDC25B, CCND2, E2F2, CDKN2D, SMC3, YWHAE, ABL1, ORC3, BUB3, SMC1A, SKP1, SKP2, CCNH, CDKN2B, RBX1, DBF4, CDKN2A, ORC2, CDKN2C, TFDP1, ANAPC13, CDC25C, CDC16, ANAPC10, SMAD2",0.401209493236885,0.101823516502323,FALSE
+"H1648","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.41843,1.27,0.149,3342,0.578,"CXCL10, CXCL9, CXCL11, CXCL6, CXCL3, CX3CL1, CCL5, NFKBIA, CCL22, CCR3, CXCL1, CXCL2, CCL20, IKBKB, LYN, CCL28, PF4, CCL17, CXCL8, GRK6, CCL19, FOXO3, CXCL16, BRAF, PIK3CB, GRK7, PPBP, CCL3, RAC2, GRK2, ADCY4, PLCB3, MAP2K1, PTK2B, VAV1, PAK1, CCL26, ADCY6, PRKCZ, TIAM1, PTK2, CSK, ADCY3, NFKB1, CXCR6, STAT2, CCR7, CCL3L3",0.826813731587726,0.238072161579471,FALSE
+"H1648","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.33339,1.01,0.415,5756,0.901,"NFKBIA, IKBKB, E2F1, BCR, SMAD3, BRAF, PIK3CB, RUNX1, CBLC, MAP2K1, HDAC2, MECOM, BAD, TGFB3, NFKB1, PIK3CA, MYC, TGFBR2, IKBKG, STAT5A, RELA, TGFB2, CDK6, RAF1, HDAC1, STAT5B, BCL2L1, TGFB1, CCND1, MAP2K2, SHC2",0.381951903287907,0.045275209020937,FALSE
+"H1648","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.47974,1.44,0.0573,3056,0.545,"NR1D1, BHLHE41, BHLHE40, PER1, CSNK1E",1.24184537803261,0.263603497723358,FALSE
+"H1648","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.31856,-1.17,0.262,18284,0.673,"MDH1, OGDH, ACO1, SDHC",0.581698708680255,0.171984935776023,FALSE
+"H1648","Input","KEGG_COLORECTAL_CANCER",-0.23639,-0.849,0.628,17100,0.84,"AXIN2, RHOA, APC, TCF7L1, BCL2, PIK3R1, AKT3, TGFBR1, MAPK8, SMAD2",0.202040356262804,0.0757207139381184,FALSE
+"H1648","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.37195,1.12,0.286,4100,0.719,"C9, CFB, THBD, PROC, C5AR1, PLAU, SERPINF2, VWF, PLAT, C3, F5, F3, F12, FGG, PLAUR, SERPINA5, CFH, SERPINA1",0.543633966870957,0.143271109617117,FALSE
+"H1648","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.28336,0.864,0.662,879,1,"AHCY, IL4I1, AMD1, SDS",0.1791420105603,0,FALSE
+"H1648","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.51645,1.56,0.0309,3922,0.498,"CXCL10, IFNL1, IFNL3, CRLF2, IFNB1, CXCL9, CXCL11, IFNL2, CXCL6, CXCL3, CX3CL1, CCL5, IL23A, CCL22, IFNGR1, CSF2, CCR3, IL1R2, LTB, CXCL1, TNFSF18, CD27, TNFRSF18, CXCL2, CCL20, CSF3, IL20RA, CCL28, PF4, IL9R, CCL17, MET, CXCL8, IL1A, BMPR1B, IL4R, CD40, CCL19, TNFRSF21, CXCL16, BMP7, EGF, VEGFC, IL15RA, TNFRSF10A, TNFSF13, CSF2RA, PPBP, CCL3, IL6, BMP2, IL18, IL10RB, INHBE, TNFRSF14, TNFRSF1B, IFNLR1, CSF1, IL19, CCL26, PDGFB, AMH, NGFR, TNFSF15, TNF, PDGFA, TGFB3, CXCR6, IL1R1, CCR7, IL20RB, CSF1R, CCL3L3, TNFSF14, LTBR, IL22RA1, IFNAR2, LIF, RELT, TGFBR2, INHBB, TNFSF10, TNFRSF10D",1.51004152057517,0.302770657240282,FALSE
+"H1648","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.56446,1.7,0.016,2184,0.762,"CXCL10, IFNB1, RIPK3, CCL5, NFKBIA, DDX58, IKBKE, IKBKB, IRF7, IL6, IRF3, IL18",1.79588001734408,0.1180450286604,FALSE
+"H1648","Input","KEGG_DILATED_CARDIOMYOPATHY",0.22268,0.664,0.936,3111,1,"ITGB6, CACNB1, TNNI3, ITGA2, ITGB4, ITGB8, ADCY4, LAMA2, ADCY6, CACNA1F, CACNB4, TNF, ITGAV, TGFB3, ADCY3",0.0287241512618947,0,FALSE
+"H1648","Input","KEGG_DNA_REPLICATION",0.272,0.815,0.746,5279,1,"RNASEH2C, RNASEH1, RFC4, POLD4, MCM2, RPA4, MCM5, MCM7, POLE2, RFC5, POLA2, POLE",0.127261172527331,0,FALSE
+"H1648","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.39202,1.17,0.25,2350,0.671,"ETV6, ETV7, PIWIL4, NOTCH3, MAP2K1",0.602059991327962,0.173277479831008,FALSE
+"H1648","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.31734,0.949,0.538,5269,0.973,"ADH7, CYP2E1, ALDH3A1, CYP2D6, ALDH1A3, GSTM1, GSTO2, CYP2C18, GSTT2, GSTK1, ALDH3B2, MGST1, MAOA, ADH1A, GSTP1, MGST2, GSTM3",0.269217724333611,0.0118871597316481,FALSE
+"H1648","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.33408,0.999,0.423,4726,0.908,"XDH, UMPS, NAT1, UPP1, HPRT1, GMPS, GUSB, UCKL1, TYMP, CDA, IMPDH1",0.373659632624958,0.0419141514789149,FALSE
+"H1648","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.28407,0.856,0.672,3805,1,"ITGB6, LAMC2, CHAD, LAMA3, ITGA2, AGRN, LAMB3, CD47, ITGB4, ITGB8, VWF, SDC1, THBS4, LAMA2, ITGAV, SDC4, LAMA5, THBS1, HMMR",0.172630726946175,0,FALSE
+"H1648","Input","KEGG_ENDOCYTOSIS",0.323,0.97,0.483,4228,0.973,"ITCH, SRC, RAB11FIP1, CHMP4B, EPN3, TFRC, MET, FGFR3, CLTB, HGS, GRK6, SMURF1, ARAP1, ACAP3, EGF, ADRB2, ACAP2, ARAP3, RUFY1, GRK7, CHMP6, GRK2, VPS37B, PSD4, CBLC, RAB11FIP4, CHMP4C, IGF1R, IQSEC1, CLTA, ASAP2, ARAP2, VPS37C, PRKCZ, LDLR, CHMP4A, SH3GLB2, GIT1, ARF6, RAB11A, CSF1R, ERBB3, HSPA1B, AP2M1, HSPA1A, RAB22A, FGFR2, WWP1, ACAP1, AGAP2, DNM2",0.316052869248488,0.0118871597316481,FALSE
+"H1648","Input","KEGG_ENDOMETRIAL_CANCER",0.18238,0.552,0.991,3622,1,"CDH1, FOXO3, EGF, BRAF, PIK3CB, MAP2K1, BAD, PIK3CA, MYC",0.00392634551472468,0,FALSE
+"H1648","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.51814,1.56,0.0269,4862,0.498,"ATP6V0D2, CCL5, SRC, NFKBIA, ATP6V1C2, CXCL1, IKBKB, LYN, MET, CXCL8, PLCG2, ADAM17, MAPK9, TCIRG1, MAPK13, PTPRZ1, ATP6V0E1, HBEGF, TJP1, ATP6V0A2, PAK1, MAPK10, MAP3K14, ATP6V0B, F11R, ATP6V1H, CSK, NFKB1, GIT1, ATP6V0E2, NOD1, ATP6V1C1, ATP6V1A, IKBKG, ADAM10, RAC1, RELA, MAPK12, EGFR",1.57024771999759,0.302770657240282,FALSE
+"H1648","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.39761,1.18,0.214,3664,0.672,"SRC, EREG, NCK1, BTC, AREG, PLCG2, PAK6, EGF, BRAF, PIK3CB, MAPK9, PAK2, EIF4EBP1, HBEGF, CBLC, TGFA, MAP2K1, PAK1, MAPK10, RPS6KB2, BAD, PTK2, ERBB3, PIK3CA, MYC, MTOR",0.669586226650809,0.172630726946175,FALSE
+"H1648","Input","KEGG_ETHER_LIPID_METABOLISM",0.2868,0.861,0.66,5129,1,"PLA2G4E, LPCAT4, PLA2G4B, PLA2G10, PLPP3, PLPP2, PLA2G12A, AGPS, PLD2, PLA2G2F, LPCAT2, PLD1",0.180456064458131,0,FALSE
+"H1648","Input","KEGG_FATTY_ACID_METABOLISM",-0.23858,-0.879,0.59,18120,0.842,"HADH, ACADM, ALDH1B1, ACAA2, ECI2, ALDH9A1",0.229147988357856,0.0746879085003505,FALSE
+"H1648","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.31999,0.967,0.502,4757,0.969,"PLA2G4E, CSF2, LYN, PLCG2, PIK3CB, MAPK9, MAPK13, RAC2, PLA2G4B, PLA2G10, MAP2K1, VAV1, MAPK10, SYK, TNF, PIK3CA, PLA2G12A, LAT, PLA2G2F, VAV3, RAC1, PRKCD, MAPK12",0.299296282854981,0.0136762229492347,FALSE
+"H1648","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.26203,0.788,0.799,5129,1,"PLA2G4F, PLA2G4E, LYN, PLCG2, PIK3CB, RAC2, PLA2G4B, MAP2K1, VAV1, PAK1, ASAP2, SYK, PLPP3, RPS6KB2, LIMK2, PLPP2, SPHK1, ARF6, PIK3CA, MYO10, DNM2, LAT, PLD2, PLA2G4D, VAV3, RAC1, PRKCD, WASL, RAF1, PLD1",0.0974532206860086,0,FALSE
+"H1648","Input","KEGG_FOCAL_ADHESION",0.25253,0.763,0.809,3032,1,"SRC, BIRC3, DIAPH1, ITGB6, MET, LAMC2, CHAD, LAMA3, ITGA2, LAMB3, PAK6, EGF, VEGFC, BRAF, PIK3CB, MAPK9, ITGB4, ITGB8, PAK2, RAC2, ARHGAP5, VWF, MAP2K1, VAV1, THBS4, LAMA2, CAV2, PAK1, IGF1R, MAPK10, PDGFB, BAD, ITGAV, PDGFA, PTK2",0.0920514783877277,0,FALSE
+"H1648","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.48535,-1.73,0.00769,12183,0.2,"GGH, ALPI, GCH1, DHFR, ALPG, ALPP, ALPL",2.11407366019857,0.698970004336019,TRUE
+"H1648","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.46895,1.42,0.0672,5512,0.487,"AKR1B10, MTMR1, PFKL, FBP2, MPI, PFKFB4, ALDOC, GMPPB, PFKFB2, TPI1, KHK, ALDOA, GMDS, HK2, PFKFB3, AKR1B1, PFKP, HK1",1.17263072694617,0.312471038785366,FALSE
+"H1648","Input","KEGG_GALACTOSE_METABOLISM",0.39746,1.19,0.224,6475,0.689,"GLA, GALT, PFKL, GANC, GAA, GALE, HK2, AKR1B1, PGM2, PFKP, HK1, B4GALT2, HK3, B4GALT1",0.649751981665837,0.161780778092374,FALSE
+"H1648","Input","KEGG_GAP_JUNCTION",-0.2056,-0.734,0.821,14131,0.914,"PRKCB, MAPK1, TUBB6, DRD1, GNAS, TUBB2B, ADCY2, GUCY1B1, ADCY1, TUBB8, PDGFRA, DRD2, KRAS, GUCY1A2, MAPK7, TUBA3D, CDK1, TUBB4A, PRKG1, PDGFD, TUBA1B, PRKACA, PDGFRB, TUBA8, TUBB2A, ADCY9, PRKACB, ITPR2, PLCB4, TUBB3, LPAR1, TUBB, NRAS, GNAQ, GNAI1, TUBA1A",0.0856568428805592,0.0390538042661686,FALSE
+"H1648","Input","KEGG_GLIOMA",0.24531,0.738,0.843,3664,1,"E2F1, PLCG2, EGF, BRAF, PIK3CB, CALML6, TGFA, MAP2K1, IGF1R, PDGFB, PDGFA, CALML5, PIK3CA, MTOR",0.0741724253752577,0,FALSE
+"H1648","Input","KEGG_GLUTATHIONE_METABOLISM",0.44987,1.36,0.107,3859,0.525,"G6PD, GPX2, GSS, GGT6, GSR, OPLAH, GGT1, PGD, GPX3, GSTM1, GSTO2, GSTT2, GCLM, GGCT, GGT7, GSTK1, MGST1",0.97061622231479,0.279840696594043,FALSE
+"H1648","Input","KEGG_GLYCEROLIPID_METABOLISM",0.36643,1.1,0.299,5958,0.716,"DGAT1, LIPG, GLA, MBOAT2, DGKQ, AGPAT3, DGKA, DGAT2, AKR1A1, PLPP3, GPAT3, PLPP2, DGKG, DGKE, MBOAT1, CEL, DGKH, ALDH3A2, AGPAT2, AKR1B1, AGPAT4, TKFC, GLYCTK, GPAT4",0.52432881167557,0.145086977692144,FALSE
+"H1648","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40692,1.21,0.198,4873,0.645,"PLA2G4E, PISD, LPCAT4, LYPLA1, PTDSS1, PCYT1A, CHKB, MBOAT2, PGS1, PLA2G4B, PLA2G10, DGKQ, AGPAT3, DGKA, PLPP3, GPAT3, PLPP2, DGKG, DGKE, MBOAT1, CDS1, PLA2G12A, GPD2, PCYT2, ACHE, DGKH, PLD2, PLA2G2F, LPCAT2, LYPLA2, AGPAT2",0.703334809738469,0.190440285364732,FALSE
+"H1648","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.32615,-1.17,0.235,16750,0.673,"CTH, DMGDH, PHGDH, PSPH, GNMT, GLDC, PSAT1, SRR",0.628932137728264,0.171984935776023,FALSE
+"H1648","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.3453,1.04,0.39,6874,0.846,"ADH7, ALDH3A1, ALDH1A3, PFKL, FBP2, AKR1A1, ALDOC, PKM, DLAT, ALDH3B2, GPI, TPI1, LDHAL6B, ALDOA, GAPDH, HK2, ALDH3A2, ADH1A, ACSS2, GALM, PGM2, PFKP, LDHB, HK1, ADH6, PGAM1, LDHA, HK3, ALDH2, PCK2, ALDH3B1, FBP1",0.408935392973501,0.0726296369609765,FALSE
+"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36842,1.1,0.317,3293,0.716,"B4GALT7, CHST11, B3GALT6, DSE, XYLT2, CHST15, CSGALNACT1",0.498940737782249,0.145086977692144,FALSE
+"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.28866,0.873,0.644,3227,1,"HS3ST1, B4GALT7, HS6ST2, B3GALT6, XYLT2, EXT1",0.191114132640188,0,FALSE
+"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.34764,1.04,0.397,3626,0.846,"B3GNT7, CHST6, CHST4, FUT8, B4GALT4",0.401209493236885,0.0726296369609765,FALSE
+"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.43688,1.32,0.106,5562,0.569,"HYAL4, IDS, SGSH, GUSB, HGSNAT, HYAL3, HEXA, HYAL1, IDUA, NAGLU, HPSE",0.97469413473523,0.244887733604929,FALSE
+"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.19525,-0.705,0.913,14842,0.911,"ST3GAL2, ST8SIA1, ST8SIA5, B4GALNT1, ST6GALNAC3",0.039529222465701,0.0404816230270017,FALSE
+"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.53022,1.6,0.0339,2720,0.673,"GLA, FUT2, B3GALT5, FUT1, A4GALT",1.46980030179692,0.171984935776023,FALSE
+"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.49605,1.51,0.0481,3986,0.46,"ABO, B3GNT3, FUT3, FUT2, B3GALT5, B3GNT4, B3GNT5, FUT1, FUT4, B4GALT4, ST3GAL4, GCNT2",1.31785492362617,0.337242168318426,FALSE
+"H1648","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.38619,1.16,0.242,4959,0.685,"PIGU, PIGB, PIGZ, PIGX, GPAA1, PIGQ, PIGS, PIGO, PIGL, PIGH, PIGW",0.616184634019569,0.164309428507574,FALSE
+"H1648","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.60637,-2.27,0,17388,0.0907,"MTHFD2, HYI, MDH1, ACO1, GRHPR",Inf,1.0423927129399,TRUE
+"H1648","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.26855,0.819,0.732,5175,1,"MAP3K4, SRC, PLA2G4E, MAPK9, MAPK13, CALML6, ADCY4, PLA2G4B, PLCB3, PLA2G10, HBEGF, MAP2K1, PTK2B, MAPK10, ADCY6, CACNA1F, ADCY3, MMP14, CALML5, MAP3K2, ITPR3, PLA2G12A, LHB, PLD2, PLA2G2F, PRKCD, MAPK12, CAMK2G, EGFR, ADCY7, RAF1, PLD1, MAP3K1",0.135488918941608,0,FALSE
+"H1648","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.38487,1.15,0.257,2957,0.673,"IL1A, IL6, TNF",0.590066876668705,0.171984935776023,FALSE
+"H1648","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.21478,-0.767,0.709,16454,0.878,"BMP8A, BMP8B, HHIP, BMP6, PRKACA, WNT2B, GAS1, PRKACB, GLI2, SUFU, WNT5A, GLI3, CSNK1G3, RAB23",0.149353764816933,0.0565054840938974,FALSE
+"H1648","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.42186,1.27,0.136,3286,0.578,"ITGAM, CSF2, IL1R2, CSF3, TFRC, IL9R, IL1A, ITGA2, IL4R, CSF2RA, IL6, CD9, CSF1, TNF, IL1R1, CSF1R",0.866461091629782,0.238072161579471,FALSE
+"H1648","Input","KEGG_HISTIDINE_METABOLISM",0.42285,1.27,0.139,4814,0.578,"LCMT1, ALDH3A1, ALDH1A3, TRMT11, HNMT, ACY3, ALDH3B2, HEMK1, MAOA, HAL, AOC1, ALDH3A2",0.856985199745905,0.238072161579471,FALSE
+"H1648","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.41424,1.23,0.184,3359,0.618,"EME1, RAD51B, RAD51, MUS81, XRCC2, RAD51D, MRE11, RAD54L, POLD4, RAD54B, RPA4",0.735182176990464,0.209011524911184,FALSE
+"H1648","Input","KEGG_HUNTINGTONS_DISEASE",-0.21836,-0.789,0.789,17299,0.856,"POLR2G, DCTN2, CLTCL1, CREB3L1, UQCRQ, RCOR1, HIP1, NDUFB3, PLCB4, PPARGC1A, COX7A2, AP2S1, BDNF, NDUFA8, CREB3L2, NDUFA7, NDUFA4, NDUFS4, GNAQ, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APAF1, COX6B1, NDUFB2, SDHC, DCTN1, ATP5MC2, NDUFS5",0.10292299679058,0.0675262353228468,FALSE
+"H1648","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.25701,0.773,0.81,3041,1,"ITGB6, CACNB1, TNNI3, ACE, ITGA2, ITGB4, ITGB8, IL6, LAMA2, CACNA1F, CACNB4, TNF, ITGAV, TGFB3",0.0915149811213502,0,FALSE
+"H1648","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.27439,0.818,0.74,5554,1,"INPP4A, PLCG2, IPMK, PIK3CB, INPP4B, PLCB3, SYNJ2, PIK3C2B, IPPK, PIK3C2G, PIK3CA, OCRL, TPI1, ISYNA1, INPP5K, PIP4K2C, PLCD3, INPP5E, INPPL1",0.130768280269024,0,FALSE
+"H1648","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.21936,0.666,0.924,7068,1,"IKBKB, PYGL, BRAF, PIK3CB, MAPK9, MKNK1, CALML6, FOXO1, EIF4EBP1, FBP2, CBLC, MAP2K1, MAPK10, RPS6KB2, BAD, SH2B2, PRKCZ, CALML5, TRIP10, PTPRF, PRKAR1B, PHKG2, PIK3CA, MTOR, SOCS2, ACACA, INSR, MKNK2, IRS1, HK2, PRKAB1, INPP5K, SOCS1, PPP1R3D, PHKG1, RAF1, EXOC7, HK1, SOCS3, MAP2K2, SHC2, FASN, PHKA1, TSC2, SOS1, PRKCI, HK3, PRKAA1, CRKL, SOS2, GYS1, LIPE, INPP5D, PYGM, PRKAG2, PCK2, FBP1, FLOT2, PHKA2, CALM2",0.0343280287798933,0,FALSE
+"H1648","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.51136,1.56,0.0337,4573,0.498,"PIGR, CCL28, ICOSLG, CD40, IL15RA, TNFSF13, IL6, MAP3K14, LTBR, MADCAM1, IL15",1.47237009912866,0.302770657240282,FALSE
+"H1648","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.40928,1.24,0.166,4604,0.607,"IFNL1, IFNL3, CRLF2, IFNB1, IFNL2, IL23A, IFNGR1, CSF2, CSF3, IL20RA, IL9R, SPRY3, IRF9, IL4R, PIK3CB, IL15RA, CSF2RA, SPRY1, PTPN6, IL6, CBLC, IL10RB, IFNLR1, IL19, STAT6, TYK2, STAT2, IL20RB, PIK3CA, IL22RA1, MYC, IFNAR2, LIF, SOCS2, CCND3, IFNGR2, PIM1, JAK3, CLCF1, OSMR, STAT5A, IL15, SOCS7",0.779891911959945,0.216811308924742,FALSE
+"H1648","Input","KEGG_LEISHMANIA_INFECTION",0.46633,1.4,0.0794,3125,0.513,"ITGAM, NFKBIA, IFNGR1, TLR2, IL1A, NCF4, ITGB2, TAB2, MAPK13, PTPN6, C3, IRAK1, CYBA, TNF, TGFB3, MYD88, NFKB1",1.1001794975729,0.289882634888184,FALSE
+"H1648","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.42995,1.3,0.136,3977,0.566,"MMP9, CLDN18, ITGAM, CLDN9, CLDN10, CLDN8, NCF4, CLDN20, PLCG2, ITGB2, CLDN7, CTNND1, PIK3CB, CLDN3, AFDN, MAPK13, CLDN23, RAC2, CLDN4, ARHGAP5, CLDN1, OCLN, PTK2B, VAV1, EZR, RAPGEF3, F11R, CYBA, PTK2, SIPA1, PIK3CA, NOX1, NCF2, RASSF5, TXK, PXN",0.866461091629782,0.247183568811729,FALSE
+"H1648","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.5,-1.81,0.0142,18443,0.213,"ALDH1B1, ALDH9A1",1.84771165561694,0.671620396561262,TRUE
+"H1648","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.61142,1.82,0.00349,2088,0.549,"AKR1B10, PLA2G4E, CYP2E1, CYP2J2, PLA2G4B, PLA2G10, CYP2C18",2.45717457304082,0.260427655549908,FALSE
+"H1648","Input","KEGG_LONG_TERM_DEPRESSION",0.18565,0.56,0.991,2608,1,"PLA2G4E, LYN, BRAF, PLA2G4B, PLCB3, PLA2G10, MAP2K1, IGF1R",0.00392634551472468,0,FALSE
+"H1648","Input","KEGG_LONG_TERM_POTENTIATION",-0.27282,-1.01,0.393,16947,0.773,"CALM1, RAP1B, PRKACA, PRKACB, ITPR2, CAMK4, RPS6KA2, PLCB4, RPS6KA1, ATF4, NRAS, GNAQ, CALM3, PPP3CB, PPP3R1",0.405607449624573,0.111820506081675,FALSE
+"H1648","Input","KEGG_LYSINE_DEGRADATION",-0.29843,-1.11,0.289,17259,0.626,"SETDB1, EHMT1, HADH, ALDH1B1, AASS, OGDH, ALDH9A1, NSD1",0.539102157243452,0.20342566678957,FALSE
+"H1648","Input","KEGG_LYSOSOME",0.42184,1.26,0.165,6147,0.571,"CTSE, ATP6V0D2, AP3M2, GGA2, NAPSA, LAMP3, CTSS, GLA, LAPTM5, IDS, ABCB9, MANBA, CLTB, IGF2R, CD164, CTSH, GGA3, TCIRG1, AP3B2, GM2A, AP1S3, CTSV, ATP6V0A2, SGSH, CLTA, ATP6V0B, GUSB, SLC11A2, CTSA, ATP6V1H, AP4S1, AP1M2, HGSNAT, GAA, ENTPD4, MFSD8, SUMF1, CTSD, LGMN, ACP5, GNPTG, SORT1, HEXA, CTSB, HYAL1, IDUA, M6PR, MAN2B1, ATP6V0C, CTSC, NAGLU, ARSA, ARSG, NPC1, NPC2, AP3D1, PSAP, LAPTM4B, LIPA, GGA1, FUCA1, CLN5, CTSZ",0.782516055786094,0.243363891754152,FALSE
+"H1648","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.28446,0.85,0.671,3822,1,"MAP3K4, PLA2G4E, IL1R2, FGF17, IKBKB, DUSP5, CACNB1, DUSP10, NFKB2, FGFR3, DUSP9, NTF4, IL1A, GADD45A, FGF11, FGF13, NFATC4, RELB, RASGRP1, TAB2, EGF, BRAF, MAPK9, MAPK13, MKNK1, MAP3K13, PAK2, RAC2, MAP3K8, RPS6KA4, PLA2G4B, CHP2, PLA2G10, MAP2K1, RASA2, TRAF2, DUSP7, PAK1, MAPK10, MAP3K14, MAPKAPK5, MAPKAPK3, MECOM, CACNA1F, MAPK8IP3, CACNB4, PDGFB, GADD45B, TNF, PDGFA, TGFB3, NFKB1, IL1R1, STK3, MAP3K2, MAP3K5, MAP4K1, HSPA1B, MYC, MAP4K4, TGFBR2, HSPA1A, FGFR2",0.173277479831008,0,FALSE
+"H1648","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.43762,1.32,0.109,2498,0.569,"HES1, MNX1, HNF1B, HNF4G, FOXA2",0.962573502059376,0.244887733604929,FALSE
+"H1648","Input","KEGG_MELANOGENESIS",0.20532,0.619,0.956,3376,1,"WNT9A, DVL1, DVL3, WNT7A, WNT10A, CALML6, ADCY4, PLCB3, MAP2K1, FZD5, ADCY6, ASIP, ADCY3, CALML5, CREB3, FZD6",0.0195421077238999,0,FALSE
+"H1648","Input","KEGG_MELANOMA",0.30215,0.91,0.595,3017,1,"FGF17, MET, E2F1, FGF11, FGF13, CDH1, EGF, BRAF, PIK3CB, MAP2K1, IGF1R, PDGFB, BAD, PDGFA",0.22548303427145,0,FALSE
+"H1648","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43184,1.3,0.13,4142,0.566,"ADH7, CYP2E1, AKR1C2, CYP1A1, ALDH3A1, AKR1C3, ALDH1A3, GSTM1, GSTO2, CYP2C18, AKR1C1, GSTT2, CYP1B1, GSTK1, ALDH3B2, MGST1, CYP2S1",0.886056647693163,0.247183568811729,FALSE
+"H1648","Input","KEGG_MISMATCH_REPAIR",-0.19457,-0.712,0.825,19056,0.924,"RPA2",0.0835460514500749,0.0343280287798933,FALSE
+"H1648","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.26238,0.787,0.778,4058,1,"ULK1, RICTOR, VEGFC, BRAF, PIK3CB, EIF4EBP1, RPS6KB2, ULK3, STK11, PIK3CA, MTOR, HIF1A",0.109020403010311,0,FALSE
+"H1648","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.32157,0.965,0.501,4750,0.949,"IFNB1, IFNGR1, CSF2, PLCG2, ITGB2, NFATC4, BRAF, PIK3CB, SH3BP2, TNFRSF10A, RAC2, ICAM2, PTPN6, CHP2, MAP2K1, PTK2B, VAV1, PAK1, SYK, TNF, LCK, PIK3CA, IFNAR2, TNFSF10, TNFRSF10D, IFNGR2, TNFRSF10C, TNFRSF10B, LAT, NFATC2, CD244, VAV3, RAC1, NFAT5",0.300162274132754,0.0227337875727074,FALSE
+"H1648","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34881,1.04,0.405,2809,0.846,"DRD5, GALR2, NPBWR1, GABRP, S1PR4, HTR7, P2RY6, MC3R, P2RY2, LTB4R2, LTB4R, GABRG2, MTNR1A, PTAFR, P2RX5, C5AR1, GABRE, S1PR5, TSHB, ADRA1B, ADRB2, GRIN2D, SSTR2, GRIN1, VIPR1, CHRM3, ADORA2A, PRSS1, P2RX6, GRIN3B, GIPR, CHRNB1, GABRA3",0.392544976785331,0.0726296369609765,FALSE
+"H1648","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24207,0.728,0.86,4853,1,"NFKBIA, IRAK2, IKBKB, NTF4, PLCG2, FOXO3, BRAF, NFKBIE, PIK3CB, MAPK9, MAPK13, CALML6, RPS6KA4, MAP2K1, IRAK1, PRDM4, MAPK10, BAD, NGFR, SH2B2, CSK, NFKB1, CALML5, PSEN1, MAP3K5, RIPK2, PIK3CA, ZNF274, SORT1, RAC1, RELA, IRS1, PRKCD, MAPK12, IRAK3, CAMK2G, YWHAZ",0.0655015487564323,0,FALSE
+"H1648","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.32396,0.965,0.485,4624,0.949,"NADK, NAMPT, NADSYN1, NMNAT3, PNP, NT5C1B, NT5C2, QPRT, NT5E",0.314258261397736,0.0227337875727074,FALSE
+"H1648","Input","KEGG_NITROGEN_METABOLISM",0.28304,0.862,0.671,4648,1,"CA13, CA7, GLUD1, GLUL, HAL, GLS2",0.173277479831008,0,FALSE
+"H1648","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.48837,1.47,0.062,3916,0.497,"CCL5, NFKBIA, BIRC3, CXCL1, TNFAIP3, CXCL2, IKBKB, CXCL8, TAB2, MAPK9, MAPK13, IL6, PSTPIP1, IL18, CARD6, MAPK10, NOD2, TNF, NFKB1, NLRP1, TAB3, RIPK2, NOD1, CARD9",1.20760831050175,0.303643611266668,FALSE
+"H1648","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.3414,-1.28,0.118,15827,0.665,"XRCC6, XRCC4, NHEJ1, RAD50, XRCC5",0.928117992693875,0.177178354696895,FALSE
+"H1648","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26511,0.808,0.749,5702,1,"E2F1, PLCG2, FOXO3, EGF, BRAF, PIK3CB, TGFA, MAP2K1, BAD, RXRA, PIK3CA, RASSF5, CDK6, EGFR, RAF1, CCND1, ERBB2, MAP2K2",0.125518182300534,0,FALSE
+"H1648","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.51853,1.56,0.0392,2688,0.498,"DVL1, DVL3, DTX4, RFNG, DTX3L, JAG1, ADAM17, DLL1, HES1, HES5, NOTCH3, DTX2, JAG2, KAT2A, HDAC2",1.40671393297954,0.302770657240282,FALSE
+"H1648","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.38986,-1.37,0.0811,15123,0.674,"RFC1, XPA, GTF2H1, ERCC4, RAD23B, GTF2H4, RPA1, RFC2, ERCC1, RAD23A, ERCC6, ERCC2, ERCC8, CCNH, RBX1, XPC, CUL4A, RPA2",1.09097914578884,0.17134010346468,FALSE
+"H1648","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.26447,0.79,0.79,4552,1,"ALG3, MGAT4B, RFT1, RPN2, RPN1, MGAT1, ALG10, ALG10B, FUT8, MAN2A2, MOGS, DPAGT1, MGAT2, TUSC3, ALG8",0.102372908709559,0,FALSE
+"H1648","Input","KEGG_OLFACTORY_TRANSDUCTION",0.38106,1.14,0.255,1976,0.675,"OR4C6, OR2J3, OR5M11, OR8S1, OR6B2, OR13D1, OR1J1, OR4D2, OR13H1, OR10AD1, OR2A5, OR4L1, OR2D2, OR11H4, OR10K2, OR2A7, OR4X2, OR1G1, OR10H1, OR8G1, OR2A12, OR8B4, GUCY2D, CALML6, OR8G5, OR6A2, OR10G3, OR8B8, OR4K1",0.593459819566045,0.170696227168975,FALSE
+"H1648","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.22828,-0.803,0.726,14026,0.872,"ATIC, DHFR, FTCD, TYMS, MTHFD2, MTR",0.139063379299906,0.0594835150674328,FALSE
+"H1648","Input","KEGG_OOCYTE_MEIOSIS",-0.31904,-1.13,0.311,16772,0.613,"CPEB1, MAD2L2, CDC23, CALM1, PRKACA, SMC3, YWHAE, ADCY9, FBXO43, PRKACB, ITPR2, RPS6KA2, RPS6KA1, SMC1A, SKP1, PPP2R1A, RBX1, CALM3, SGO1, ANAPC13, PPP3CB, PPP2R5C, CDC25C, PPP2R5D, CDC16, PPP3R1, ANAPC10",0.507239610973163,0.212539525481585,FALSE
+"H1648","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.49486,1.49,0.042,6273,0.477,"MANBA, ENGASE, MAN2C1, FUCA2, HEXA, MAN2B1, MAN2B2, FUCA1, NEU1",1.3767507096021,0.321481620959886,FALSE
+"H1648","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.23704,-0.817,0.661,18279,0.863,"NDUFA8, NDUFA7, NDUFA4, NDUFS4, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, ATP5ME, COX6B1, NDUFB2, ATP6V1E1, SDHC, ATP5MC2, NDUFS5",0.17979854051436,0.0639892042847904,FALSE
+"H1648","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.51195,1.52,0.0492,3145,0.47,"ST6GALNAC1, GCNT3, B4GALT5, GALNT7, GALNT5, GALNT12, GALNT10, GALNT3, GALNT6, GALNT18, GALNT14",1.30803489723264,0.327902142064283,FALSE
+"H1648","Input","KEGG_P53_SIGNALING_PATHWAY",0.24741,0.746,0.834,6303,1,"ATR, GADD45A, SERPINB5, CD82, PERP, TP53I3, GADD45B, PMAIP1, SFN, EI24, RPRM, THBS1, CCND3, CYCS, TNFRSF10B, GADD45G, CDK6, IGFBP3, STEAP3, CCND1, BID, TP73, PIDD1, CHEK1, TSC2, CDKN1A, FAS",0.0788339493622613,0,FALSE
+"H1648","Input","KEGG_PANCREATIC_CANCER",0.29184,0.897,0.605,5629,1,"IKBKB, E2F1, SMAD3, EGF, VEGFC, BRAF, PIK3CB, MAPK9, RAD51, RAC2, TGFA, MAP2K1, MAPK10, BAD, TGFB3, NFKB1, PIK3CA, RALB, TGFBR2, IKBKG, RALGDS, RAC1, RELA, TGFB2, CDK6, EGFR, BRCA2, RAF1, PLD1, BCL2L1, TGFB1, CCND1, ERBB2",0.218244625347531,0,FALSE
+"H1648","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.22684,0.685,0.895,5025,1,"PPCDC, COASY, PANK4, PANK3, PANK2",0.048176964684088,0,FALSE
+"H1648","Input","KEGG_PARKINSONS_DISEASE",-0.26648,-0.986,0.397,18279,0.739,"NDUFA8, PINK1, NDUFA7, NDUFA4, NDUFS4, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APAF1, COX6B1, NDUFB2, SDHC, PARK7, ATP5MC2, NDUFS5",0.401209493236885,0.131355561605174,FALSE
+"H1648","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.31553,-1.15,0.219,16110,0.678,"TUBA3D, ROCK1, YWHAQ, TUBB4A, CD14, ACTB, TUBA1B, ARHGEF2, TUBA8, RHOA, TUBB2A, ABL1, TLR4, TUBB3, FYN, TUBB, ARPC5, TUBA1A, CDC42",0.659555885159882,0.168770306132937,FALSE
+"H1648","Input","KEGG_PATHWAYS_IN_CANCER",0.28487,0.85,0.679,3822,1,"MMP9, WNT9A, NFKBIA, DVL1, BIRC3, FGF17, IKBKB, TRAF4, DVL3, NFKB2, MET, FGFR3, E2F1, BCR, CXCL8, LAMC2, SMAD3, LAMA3, WNT7A, ITGA2, PLCG2, FGF11, FGF13, LAMB3, MMP1, PML, CDH1, EGLN3, EGF, VEGFC, WNT10A, JUP, BRAF, PIK3CB, MAPK9, CSF2RA, FOXO1, RUNX1, RAD51, RAC2, TRAF1, IL6, BMP2, CBLC, TGFA, PAX8, MAP2K1, TRAF2, VHL, LAMA2, FZD5, IGF1R, MAPK10, HDAC2, MECOM, PDGFB, BAD, ITGAV, PDGFA, PTK2, TGFB3, NFKB1, CSF1R, FZD6, LAMA5, RXRA, PIK3CA, MYC, MTOR, ELOC, TFG, RALB, TGFBR2, WNT3, FGFR2",0.168130225719498,0,FALSE
+"H1648","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.26823,0.809,0.758,2843,1,"UGDH, RPEL1, GUSB",0.120330794367946,0,FALSE
+"H1648","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50757,1.52,0.0525,5444,0.47,"G6PD, PGD, TKT, TALDO1, RPEL1, PFKL, FBP2, ALDOC, DERA, GPI, ALDOA, PGM2, PFKP",1.27984069659404,0.327902142064283,FALSE
+"H1648","Input","KEGG_PEROXISOME",0.23246,0.707,0.884,5121,1,"XDH, SOD2, ACSL5, PRDX5, PEX2, SLC27A2, PEX5, PRDX1, DDO, ACAA1, MVK, PAOX, ABCD1, GSTK1, EPHX2, PEX3, MLYCD, EHHADH, AGPS, DHRS4, SOD1, PEX7, PEX16, NUDT19, ACOT8, ACOX1",0.0535477349869269,0,FALSE
+"H1648","Input","KEGG_PHENYLALANINE_METABOLISM",0.55315,1.66,0.0255,4365,0.573,"IL4I1, ALDH3A1, AOC2, ALDH1A3, ALDH3B2, MAOA, AOC3",1.59345981956604,0.24184537803261,FALSE
+"H1648","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25378,0.764,0.8,3949,1,"INPP4A, PLCG2, PIK3CB, INPP4B, CALML6, PLCB3, DGKQ, DGKA, SYNJ2, PIK3C2B, CALML5, DGKG, DGKE, IPPK, PIK3C2G, PIK3CA, CDS1, ITPR3, OCRL",0.0969100130080564,0,FALSE
+"H1648","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.34428,1.03,0.399,3373,0.865,"CP, EARS2, FTH1, GUSB, ALAS1, HMOX2",0.399027104313252,0.0629838925351858,FALSE
+"H1648","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.18465,0.562,0.988,5588,1,"FABP6, MMP1, ACSL5, SLC27A4, ME1, SLC27A2, ACAA1, RXRA, CPT2, UBC, CYP27A1, EHHADH, ANGPTL4, CPT1C, ACOX1, CPT1A, ACSL1, SLC27A1, PPARG",0.00524305541237188,0,FALSE
+"H1648","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.28189,0.843,0.694,4036,1,"CH25H, CYP7B1, AKR1D1, CYP27A1",0.158640529545145,0,FALSE
+"H1648","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.38015,1.15,0.244,5251,0.673,"CD40, CIITA, ADA, TAP2, LCK, BLNK, IKBKG, JAK3, RAG2, UNG, TAP1",0.612610173661271,0.171984935776023,FALSE
+"H1648","Input","KEGG_PRION_DISEASES",0.30397,0.937,0.526,2350,0.983,"CCL5, C9, IL1A, IL6, MAP2K1",0.279014255846261,0.00744648216786438,FALSE
+"H1648","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28281,-1,0.36,16258,0.734,"CDK1, PDE3A, ARAF, CPEB1, MAD2L2, CDC23, CDC25B, PRKACA, ADCY9, PRKACB, RPS6KA2, RPS6KA1, PDE3B, PIK3R1, AKT3, MAPK14, GNAI1, ANAPC13, CDC25C, CDC16, MAPK8, ANAPC10",0.443697499232713,0.134303940083929,FALSE
+"H1648","Input","KEGG_PROPANOATE_METABOLISM",-0.28276,-1,0.418,14863,0.734,"ABAT, PCCA, SUCLA2, SUCLG1, ACSS1, LDHC, ACACB, HIBCH, ACADM, ALDH1B1, ALDH9A1",0.378823718224965,0.134303940083929,FALSE
+"H1648","Input","KEGG_PROSTATE_CANCER",0.23981,0.717,0.872,5702,1,"NFKBIA, IKBKB, E2F1, EGF, BRAF, PIK3CB, FOXO1, TGFA, MAP2K1, IGF1R, PDGFB, BAD, PDGFA, NFKB1, CREB3, PIK3CA, MTOR, FGFR2, IKBKG, RELA, CREB5, EGFR, GSTP1, RAF1, TCF7, CCND1, ERBB2, MAP2K2",0.0594835150674328,0,FALSE
+"H1648","Input","KEGG_PROTEASOME",0.27494,0.823,0.731,3211,1,"PSME4, PSME2, PSMB11, PSME1, PSMD11, PSMF1, PSMA5, PSMD2, PSMB5, PSMB10, PSMA6",0.13608262304214,0,FALSE
+"H1648","Input","KEGG_PROTEIN_EXPORT",0.271,0.807,0.739,4969,1,"OXA1L, SRPRA, SEC63, SRP54, SRPRB, SEC11A, SEC62, SRP68, SEC61A1",0.131355561605174,0,FALSE
+"H1648","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.16518,0.503,0.994,5399,0.996,"SLC25A10, GLUD1, ATP1B3, GLS2, ATP1A3, ATP1B1",0.00261361560268669,0.00174066157630127,FALSE
+"H1648","Input","KEGG_PURINE_METABOLISM",-0.19398,-0.665,0.914,16712,0.937,"POLR2D, NME7, NPR2, RRM2B, PDE1C, PDE7B, POLA1, PDE6B, PDE6G, POLR2G, PAPSS1, ADSL, ADCY9, PDE10A, PDE8B, PDE6D, APRT, PRUNE1, AK5, PDE3B, PDE4B, PRIM2, AK7, ENPP1, PAPSS2, NT5M, DCK, POLR3GL, DGUOK, POLR1E",0.0390538042661686,0.0282604091122217,FALSE
+"H1648","Input","KEGG_PYRIMIDINE_METABOLISM",0.21269,0.636,0.95,5377,1,"ENTPD3, POLR2H, UMPS, CMPK2, TXNRD1, POLR1B, PNP, UPP1, NME6, NT5C1B, POLD4, ENTPD4, UCKL1, PNPT1, DUT, NT5C2, TYMP, CDA, POLE2, POLR1C, NT5E, CAD, CMPK1, POLA2, NT5C, POLE, ENTPD5, NME5",0.0222763947111523,0,FALSE
+"H1648","Input","KEGG_PYRUVATE_METABOLISM",-0.23207,-0.861,0.617,18284,0.861,"MDH1, ALDH1B1, ALDH9A1, GRHPR",0.209714835966758,0.0649968485463452,FALSE
+"H1648","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.25971,0.778,0.801,3219,1,"ITGAM, FGF17, PFN4, DIAPH1, ITGB6, ARHGEF4, FGFR3, TMSB4Y, ITGA2, FGF11, FGF13, ITGB2, PAK6, EGF, BRAF, PIK3CB, BAIAP2, ITGB4, ITGB8, SSH3, MYH14, PAK2, RAC2, CHRM3, SSH1, MAP2K1, VAV1, FGD3, EZR, PAK1, ITGAX, PDGFB, ITGAV, TIAM1, LIMK2, PDGFA, PTK2, CSK, GIT1",0.0963674839157623,0,FALSE
+"H1648","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.24812,0.753,0.859,1482,1,"ULK1, ATG5, PIK3R4, BECN1",0.0660068361687577,0,FALSE
+"H1648","Input","KEGG_RENAL_CELL_CARCINOMA",0.22262,0.669,0.933,5045,1,"MET, PAK6, EGLN3, VEGFC, BRAF, PIK3CB, PAK2, TGFA, MAP2K1, VHL, PAK1, PDGFB, TGFB3, PIK3CA, ELOC, HIF1A, RAC1, TGFB2, ETS1, RAF1",0.0301183562535,0,FALSE
+"H1648","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.25357,0.765,0.812,5920,1,"ACE, CTSA, REN, THOP1, ACE2",0.0904439707588247,0,FALSE
+"H1648","Input","KEGG_RETINOL_METABOLISM",0.46555,1.39,0.0915,5135,0.515,"RDH16, ADH7, CYP1A1, DHRS9, DGAT1, RDH10, CYP26A1, CYP2C18, DHRS3, DGAT2, ALDH1A2, CYP26B1, LRAT, DHRS4, BCO1, ADH1A, DHRS4L2, ALDH1A1, RDH11",1.03857890593355,0.288192770958809,FALSE
+"H1648","Input","KEGG_RIBOFLAVIN_METABOLISM",0.24282,0.733,0.866,5743,1,"MTMR1, ACP6, ACP4, ACP5, ACP1, FLAD1",0.0624821079826534,0,FALSE
+"H1648","Input","KEGG_RIBOSOME",-0.51374,-1.88,0.0222,16296,0.202,"RPL9, RPL26, RPL24, RPS4X, RPL10A, RPL3, RPS24, RPS18, RPS13, RPS15, RPL7A, RPL34, UBA52, RPL21, RPL13A, RPS23, RPL27A, RPL6, RPL29, RPL5, RPL11, RPSA, RPL37A, RPL18, RPL35, RPS19, RPS16, RSL24D1, RPS9, RPS5, RPS11, RPS6, RPS27L, RPS10, RPS15A, RPS27, RPL17",1.65364702554936,0.694648630553376,TRUE
+"H1648","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.46961,1.43,0.0733,3125,0.54,"CXCL10, IFNB1, NFKBIA, DDX58, IKBKE, IKBKB, CXCL8, ATG5, DDX3Y, TRADD, ISG15, DHX58, IRF7, MAPK9, MAPK13, IRF3, IFIH1, TRAF2, MAPK10, TNF, NFKB1",1.13489602535887,0.267606240177031,FALSE
+"H1648","Input","KEGG_RNA_DEGRADATION",-0.35043,-1.28,0.138,17144,0.665,"PAPOLG, DCP2, PAPOLA, EXOSC8, MPHOSPH6, XRN2, LSM3, LSM7, TTC37, LSM2, ENO1, EXOSC3, C1D, ZCCHC7",0.860120913598763,0.177178354696895,FALSE
+"H1648","Input","KEGG_RNA_POLYMERASE",-0.25521,-0.942,0.527,14661,0.821,"POLR2C, POLR2L, POLR2J3, POLR2I, POLR2F, POLR2D, POLR2G, POLR3GL, POLR1E",0.278189384787453,0.0856568428805592,FALSE
+"H1648","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.45765,1.38,0.0967,4199,0.519,"LCMT1, AHCY, GGT6, GGT1, TRMT11, GGT7, AHCYL1, HEMK1, MAT2B",1.014573525917,0.284832642151542,FALSE
+"H1648","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.30031,0.897,0.604,3622,1,"NFKBIA, BIRC3, IKBKB, TRAF4, E2F1, LAMC2, LAMA3, ITGA2, LAMB3, PIK3CB, TRAF1, TRAF2, LAMA2, ITGAV, PTK2, NFKB1, LAMA5, RXRA, PIK3CA, MYC",0.218963061378868,0,FALSE
+"H1648","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.25951,-0.926,0.476,17365,0.806,"USE1, STX8, SNAP25, VAMP5, STX2, SEC22B, VAMP3, STX12",0.322393047279507,0.0936649581949093,FALSE
+"H1648","Input","KEGG_SPHINGOLIPID_METABOLISM",0.32506,0.964,0.497,3712,0.939,"SMPD2, GLA, SGPP2, ACER3, DEGS2, PLPP3, PLPP2, SPHK1, UGT8, SGMS2",0.303643611266668,0.0273344077338891,FALSE
+"H1648","Input","KEGG_SPLICEOSOME",0.24679,0.756,0.836,1835,1,"LSM8, SRSF6, CTNNBL1, PRPF40B, SART1, SRSF5, THOC3, U2SURP, AQR, RBM22, ACIN1, PRPF38B, NCBP2, TCERG1, TRA2B, RBM25, ZMAT2, PRPF38A, SRSF2, ISY1",0.0777937225609836,0,FALSE
+"H1648","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.20729,0.628,0.962,3831,1,"UGDH, PYGL, GANC, GUSB, UXS1, GAA, GPI",0.0168249279621871,0,FALSE
+"H1648","Input","KEGG_STEROID_BIOSYNTHESIS",-0.23238,-0.824,0.635,14250,0.872,"MSMO1, HSD17B7, SOAT1, CYP27B1, LSS, CYP51A1",0.197226274708024,0.0594835150674328,FALSE
+"H1648","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.47261,1.42,0.0843,4006,0.487,"AKR1C2, CYP1A1, AKR1C3, HSD17B3, AKR1C1, SRD5A1, CYP7B1, CYP1B1, AKR1D1, SRD5A3, HSD11B1, HSD11B2, HSD17B8, SULT2B1",1.07417242537526,0.312471038785366,FALSE
+"H1648","Input","KEGG_SULFUR_METABOLISM",0.4448,1.34,0.106,4113,0.558,"SULT1A4, SULT1A1, CHST11, SULT1A2, SULT2B1, SUOX",0.97469413473523,0.253365801062421,FALSE
+"H1648","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.22043,0.666,0.932,2957,1,"C9, CD40, C3, TNF",0.0305840876460186,0,FALSE
+"H1648","Input","KEGG_TASTE_TRANSDUCTION",0.39248,1.17,0.235,5194,0.671,"SCNN1G, SCNN1B, TAS1R3, TAS2R31, SCNN1A, ADCY4, ADCY6, ITPR3, GNB1, TAS2R20, TAS2R4, TAS2R5, GNG3, TAS2R13, TAS2R19, TAS2R10",0.628932137728264,0.173277479831008,FALSE
+"H1648","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.63202,1.92,0.00348,3251,0.56,"GGT6, GGT1, GAD1, GGT7",2.45842075605342,0.2518119729938,FALSE
+"H1648","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.61874,-2.2,0,17922,0.0644,"HMGCR, IDI1, DHDDS, FDPS, GGPS1, PMVK",Inf,1.19111413264019,TRUE
+"H1648","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.28043,-1.01,0.376,16153,0.773,"ROCK1, SMAD5, BMP8A, THBS2, RBL2, BMP8B, NOG, ID4, BMPR1A, CHRD, BMP6, ACVR2A, DCN, RHOA, SMAD9, SKP1, PPP2R1A, CDKN2B, ZFYVE16, RBX1, TFDP1, TGFBR1, BMPR2, LTBP1, SMAD2",0.424812155072339,0.111820506081675,FALSE
+"H1648","Input","KEGG_THYROID_CANCER",0.25693,0.773,0.821,5702,1,"CDH1, BRAF, PAX8, MAP2K1, RXRA, MYC, TFG, TCF7, PPARG, CCND1, CCDC6, MAP2K2",0.0856568428805592,0,FALSE
+"H1648","Input","KEGG_TIGHT_JUNCTION",0.33873,1.02,0.408,2982,0.883,"CLDN18, SRC, CLDN9, CLDN10, CLDN8, CGN, PRKCH, CLDN20, HCLS1, PPP2R2C, TJP3, CLDN7, CLDN3, AFDN, MYH14, CLDN23, EPB41L1, CRB3, CLDN4, CLDN1, OCLN, TJP1, MYH7B, YBX3, LLGL2, F11R, PPP2R2A, PRKCZ",0.38933983691012,0.0540392964224314,FALSE
+"H1648","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.50914,1.54,0.0322,3623,0.504,"CXCL10, IFNB1, CXCL9, CXCL11, CCL5, NFKBIA, IRF5, TLR6, IKBKE, TLR1, TLR2, IKBKB, CXCL8, CD40, TAB2, IRF7, PIK3CB, MAPK9, MAPK13, CCL3, MAP3K8, IL6, TICAM1, IRF3, TLR5, MAP2K1, IRAK1, MAPK10, TNF, MYD88, NFKB1, TLR3, PIK3CA, IFNAR2",1.49214412830417,0.297569463554475,FALSE
+"H1648","Input","KEGG_TRYPTOPHAN_METABOLISM",0.3607,1.1,0.308,517,0.716,"KYNU, IL4I1, CYP1A1, IDO1, KMO",0.511449283499556,0.145086977692144,FALSE
+"H1648","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29189,0.861,0.68,5887,1,"IKBKB, PIK3CB, MAPK9, MAPK10, TNF, PRKCZ, PKM, PIK3CA, MTOR, SOCS2, INSR, IRS1, HK2, PRKCD, SOCS1, HK1, SOCS3, PRKCE",0.167491087293764,0,FALSE
+"H1648","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.25809,0.764,0.812,2957,1,"IL1A, GAD1, TNF",0.0904439707588247,0,FALSE
+"H1648","Input","KEGG_TYROSINE_METABOLISM",0.44025,1.31,0.121,4885,0.576,"LCMT1, ADH7, IL4I1, ALDH3A1, AOC2, ALDH1A3, TRMT11, ALDH3B2, HEMK1, MAOA, AOC3, FAH, ADH1A",0.91721462968355,0.239577516576788,FALSE
+"H1648","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3545,1.06,0.361,4757,0.824,"NFKBIA, CSF2, CARD11, IKBKB, NCK1, DLG1, NFATC4, PAK6, RASGRP1, NFKBIE, PIK3CB, MAPK9, MAPK13, PAK2, MAP3K8, PTPN6, CHP2, CBLC, MAP2K1, VAV1, PAK1, MAP3K14, TNF, NFKB1, TEC, LCK, PIK3CA, BCL10, IKBKG, LAT, NFATC2, VAV3, RELA, NFAT5, MAPK12",0.442492798094342,0.0840727883028842,FALSE
+"H1648","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.19754,0.594,0.972,6114,1,"ITCH, BIRC3, UBE2J2, SMURF1, UBR5, PML, FBXO2, SYVN1, UBE2G2, UBE3C, CBLC, FBXW11, VHL, ANAPC7, UBE2L6, UBE2Z, UBE2K, ANAPC5, BRCA1, UBE2H, RNF7, BIRC6, HERC2, ANAPC4, ELOC, WWP1, UBA7, UBE2W, UBE2O, FZR1, ANAPC2, UBE4A, DDB1, UBE3B, SOCS1, UBA6, MAP3K1, ANAPC1, CDC34, HERC1, SOCS3, RHOBTB2, KEAP1, UBE3A, KLHL13, PIAS1, UBE2C, UBE2A, XIAP",0.0123337350737254,0,FALSE
+"H1648","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.48196,-1.75,0.0227,14636,0.223,"BCAT2, VARS2, IARS2, PDHB",1.64397414280688,0.651695136951839,TRUE
+"H1648","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.26043,-0.938,0.5,14302,0.804,"HMGCS2, HADHB, BCAT2, ACADSB, ABAT, OXCT1, PCCA, HMGCL, HSD17B10, BCKDHB, HIBADH, AOX1, HADH, HIBCH, ACADM, ALDH1B1, ACAA2, ALDH9A1",0.301029995663981,0.0947439512515487,FALSE
+"H1648","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.17472,0.535,0.991,3255,0.998,"PLA2G4E, KCNMB3, PRKCH, ADRA1B, BRAF, CALML6, ADCY4, PLA2G4B, PLCB3, PLA2G10, MAP2K1, ADORA2A, ADCY6, CACNA1F, ADCY3, CALML5",0.00392634551472468,0.000869458712628891,FALSE
+"H1648","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.3318,-1.22,0.168,15891,0.697,"AVPR2, DCTN4, DYNC1LI1, RAB5B, PRKACA, DCTN2, ADCY9, PRKACB, CREB3L1, ARHGDIA, DYNLL1, CREB3L2, DCTN6, DYNC1I2, DCTN1",0.774690718274137,0.156767221901991,FALSE
+"H1648","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.31218,0.939,0.54,5910,0.99,"SRC, PLA2G4E, PLCG2, NFATC4, PIK3CB, MAPK13, RAC2, PLA2G4B, CHP2, PLA2G10, MAP2K1, NOS3, MAPKAPK3, BAD, PTK2, SPHK1, PIK3CA, PXN, PLA2G12A, NFATC2, PLA2G2F, RAC1, NFAT5, MAPK12, RAF1, PTGS2, CHP1, MAPK11, MAP2K2, SHC2, PLA2G6",0.267606240177031,0.00436480540245009,FALSE
+"H1648","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.36553,1.1,0.305,4492,0.716,"ATP6V0D2, ATP6V1C2, KCNQ1, ERO1A, PLCG2, TCIRG1, ATP6V0E1, TJP1, ATP6V0A2, ATP6V0B, ATP6V1H, ADCY3, ATP6V0E2, SLC12A2, ATP6V1C1, ATP6V1A, TJP2",0.515700160653214,0.145086977692144,FALSE
+"H1648","Input","KEGG_VIRAL_MYOCARDITIS",0.20176,0.606,0.972,4621,1,"EIF4G1, CD40, ITGB2, MYH14, RAC2, MYH7B, LAMA2, MYH11, CXADR, CYCS, CAV1, RAC1",0.0123337350737254,0,FALSE
+"H1648","Input","KEGG_WNT_SIGNALING_PATHWAY",0.25713,0.769,0.816,4389,1,"MMP7, TBL1Y, WNT9A, DVL1, DVL3, CHD8, CSNK1A1, SENP2, PORCN, TBL1XR1, SMAD3, WNT7A, NKD2, NFATC4, WNT10A, MAPK9, CTNNBIP1, RAC2, CHP2, PLCB3, FBXW11, FZD5, RUVBL1, MAPK10, CSNK1E, FRAT2, SFRP5, FZD6, PSEN1, CSNK1A1L, MYC, WNT3, VANGL1, CCND3, VANGL2, LRP5, WNT7B, NFATC2",0.0883098412461389,0,FALSE
+"H2126","Input","KEGG_ABC_TRANSPORTERS",0.36567,1.09,0.341,3789,0.917,"ABCG2, ABCG1, ABCC2, ABCC3, ABCD1, ABCB8, ABCD4, ABCB7, ABCA12, ABCB6",0.467245621007502,0.0376306643299789,FALSE
+"H2126","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.22193,-0.757,0.795,15187,0.943,"PIK3CD, MAP2K1, PPARD, CEBPA, EIF4EBP1, CCNA1, LEF1, PIK3R1, RAF1, PIM1, PIM2, TCF7, BAD, HRAS, PML, NRAS, AKT3",0.0996328713435297,0.0254883072626717,FALSE
+"H2126","Input","KEGG_ADHERENS_JUNCTION",-0.23621,-0.87,0.603,17317,0.805,"SNAI2, VCL, CDC42, RHOA, TCF7, ACTN1, ACTG1, CSNK2B, FER, NECTIN3, ACTB, FYN, WASF1",0.219682687859849,0.0942041196321315,FALSE
+"H2126","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.42392,1.24,0.175,4364,0.766,"PRKAB1, IRS2, CPT1B, PRKAG1, TRAF2, STAT3, ADIPOR1, PRKAA2, ACSL1, PPARA, ACSL3, IKBKB, RELA, CAMKK2, RXRA, ACACB, TRADD, AKT1, PRKAB2, IKBKG, PRKAA1, CPT1C, TNFRSF1B, MTOR, TNFRSF1A",0.756961951313706,0.115771230367396,FALSE
+"H2126","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.37403,1.1,0.302,4731,0.917,"AGXT, GPT, GLUL, GFPT1, CPS1, ALDH5A1, CAD, GLS2, ALDH4A1",0.519993057042849,0.0376306643299789,FALSE
+"H2126","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.30824,0.904,0.604,4356,1,"IRS2, INS, SCNN1A, FXYD4, PIK3R3, ATP1B1, MAPK3, PRKCG, KCNJ1, MAPK1",0.218963061378868,0,FALSE
+"H2126","Input","KEGG_ALLOGRAFT_REJECTION",-0.32815,-1.19,0.242,10722,0.714,"CD28, CD40LG, IL2, FASLG, IL12B, CD80, IL4, IL10, PRF1, CD86, TNF, GZMB, FAS, IL12A",0.616184634019569,0.146301788223826,FALSE
+"H2126","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.52753,1.54,0.0458,4629,0.451,"PLA2G6, PLA2G12A, PLA2G10, ACOX3, PLA2G2D, PLA2G2C, PLA2G4A, PLA2G4B",1.33913452199613,0.345823458122039,FALSE
+"H2126","Input","KEGG_ALZHEIMERS_DISEASE",0.18914,0.556,0.986,4587,1,"CASP9, ATP2A3, UQCR11, GRIN2D, EIF2AK3, GRIN1, CALML6, ITPR1, CACNA1D, NDUFV2, APH1A, NDUFA3, PSEN1, ERN1, APAF1, NDUFV1, IDE, COX6A1, NDUFA10, ATP5MC2, MAPK3, NDUFB1, ADAM10, NDUFA5, PLCB1, SDHA, UQCRHL, PSENEN, BID, MAPK1, TNFRSF1A, COX6A2, CACNA1F, GNAQ, SDHD",0.0061230850587888,0,FALSE
+"H2126","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29099,-1.09,0.277,16444,0.609,"WARS2, FARSB, LARS2, CARS2, RARS2, YARS2, PSTK",0.557520230935551,0.215382707367125,FALSE
+"H2126","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.58332,1.72,0.0147,5813,0.652,"NANS, GMPPA, HK2, FPGT, GNPDA2, UGDH, GNPNAT1, GFPT1, GALK2, NANP, GMDS, PGM1, GNE, NPL, GMPPB, PGM3, PMM2, MPI, PGM2, CHIT1, HEXB, UGP2, GALT, GALE",1.83268266525182,0.18575240426808,FALSE
+"H2126","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.21727,0.636,0.943,4364,1,"CASP9, GRIN2D, GRIN1, SLC1A2, MAP3K5, CCS, APAF1, BAX, MAPK13, DERL1, TNFRSF1B, BID, TNFRSF1A",0.0254883072626717,0,FALSE
+"H2126","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.30656,0.909,0.593,4038,1,"CTSL, HSPA1L, CD4, LGMN, NFYC, TAPBP, IFI30, HSPA1A, CREB1, HSPA1B, HSPA2, KLRC3, PDIA3",0.226945306635737,0,FALSE
+"H2126","Input","KEGG_APOPTOSIS",0.25302,0.73,0.87,4364,1,"CASP9, IRAK4, ATM, TRAF2, XIAP, IKBKB, AIFM1, RELA, CSF2RB, TRADD, PIK3R3, APAF1, BAX, AKT1, BIRC3, MYD88, IL1R1, IKBKG, BIRC2, BID, TNFRSF1A",0.0604807473813815,0,FALSE
+"H2126","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.43071,1.28,0.141,3980,0.789,"CYP4A22, PTGES, PLA2G6, ALOX15B, PLA2G12A, CYP4F3, CYP2J2, PLA2G10, PTGES2, LTA4H, PTGDS, ALOX5, PLA2G2D, PTGS1, GPX2, EPHX2, ALOX12B, PLA2G2C, LTC4S, PLA2G4A, GPX3",0.85078088734462,0.10292299679058,FALSE
+"H2126","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.2584,0.775,0.797,6291,1,"GLUL, SAT1, PYCR1, ALDH18A1, GATM, CKMT1A, CKMT1B, ALDH2, CPS1, ALDH3A2, P4HA3, ARG1, GLS2, AGMAT, MAOA, ALDH4A1, GAMT, ASS1, P4HA2, ASL, PYCR3, ODC1",0.0985416786038876,0,FALSE
+"H2126","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.18921,0.554,0.987,4525,1,"CACNB2, CACNG1, CACNA1D, ITGB6, ITGB5, ITGA1, CACNG6, ITGA2B, JUP, DMD, ITGB1, DSP, CACNG8, CACNG4, CACNA1F",0.00568284733036327,0,FALSE
+"H2126","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.25981,0.753,0.816,3745,1,"UGDH, ALDH2, ALDH3A2",0.0883098412461389,0,FALSE
+"H2126","Input","KEGG_ASTHMA",0.25981,0.757,0.824,14150,1,"CD40, EPX, IL5, IL13, IL9, MS4A2, FCER1A, FCER1G, CD40LG, IL3, CCL11, PRG2, IL4, IL10, TNF, RNASE3",0.0840727883028842,0,FALSE
+"H2126","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.27766,0.817,0.749,170,1,"CGA",0.125518182300534,0,FALSE
+"H2126","Input","KEGG_AXON_GUIDANCE",0.21615,0.633,0.943,3790,1,"FES, RND1, SEMA4C, EFNA1, SRGAP1, EPHA1, SEMA3E, EFNA3, SEMA4B, NTN4, PLXNB2, PLXNA3, SEMA3B, PAK4, PAK6, EPHB6, EFNA4, RHOD, MAPK3, SRGAP3, EFNA5, ARHGEF12, ROCK1, ITGB1, SEMA4G",0.0254883072626717,0,FALSE
+"H2126","Input","KEGG_BASAL_CELL_CARCINOMA",0.36601,1.08,0.337,1246,0.935,"WNT3A, FZD10, WNT4, WNT7B, WNT11",0.472370099128661,0.0291883891274822,FALSE
+"H2126","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.3626,-1.27,0.135,17299,0.629,"GTF2H1, STON1, TAF9, GTF2E2, GTF2H3, TAF5, TAF7, GTF2B, TBPL1",0.869666231504994,0.201349354554731,FALSE
+"H2126","Input","KEGG_BASE_EXCISION_REPAIR",0.27861,0.823,0.729,1281,1,"LIG3, SMUG1, NEIL1, MUTYH",0.137272471682025,0,FALSE
+"H2126","Input","KEGG_BETA_ALANINE_METABOLISM",0.28488,0.841,0.723,3745,1,"AOC2, ACADM, AOC3, ALDH2, ALDH3A2",0.140861702705469,0,FALSE
+"H2126","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.27539,0.806,0.727,2367,1,"ACOT4, ACOX3, ACOT1, ACOT2",0.138465589140962,0,FALSE
+"H2126","Input","KEGG_BLADDER_CANCER",-0.31965,-1.19,0.18,15388,0.714,"MAP2K1, EGF, PGF, RASSF1, CXCL8, THBS1, CDKN1A, MMP1, RAF1, E2F2, E2F3, MMP2, TP53, CDKN2A, VEGFB, HRAS, NRAS, CDK4",0.744727494896694,0.146301788223826,FALSE
+"H2126","Input","KEGG_BUTANOATE_METABOLISM",-0.27931,-1,0.388,16610,0.628,"PDHB, ACSM3, ALDH1B1, ECHS1, ACAT1, ALDH9A1, BDH2, OXCT1",0.411168274405793,0.202040356262804,FALSE
+"H2126","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.23363,0.679,0.91,4005,1,"BLNK, VAV1, IKBKB, RELA, SOS2, CD72, PTPN6, PLCG2, PIK3R3, RASGRP3, AKT1, CD22, VAV2, MAPK3, CD19, IKBKG, SOS1",0.0409586076789064,0,FALSE
+"H2126","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.32819,0.97,0.501,3057,1,"BDKRB2, CD38, ATP2A3, BDKRB1, CACNA1I, ADCY4, PHKA1, P2RX4, GRIN2D, RYR1, GRIN1, CALML6, ITPR1, ADRA1D, ATP2B1, SLC8A2, CACNA1D, PTAFR, P2RX2, ERBB2, GNA14, PHKA2, CAMK2G, LTB4R2, PLCG2, TACR3, TRHR, ERBB3, CACNA1A",0.300162274132754,0,FALSE
+"H2126","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27836,0.821,0.733,1492,1,"CACNB2, CACNG1, TNNI3, UQCR11, CACNA1D, SLC9A1",0.134896025358872,0,FALSE
+"H2126","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.24197,0.706,0.882,3758,1,"CDH5, ITGB2, ICAM3, CD4, PTPRF, CNTN1, ICOSLG, CDH3, NRXN3, CLDN3, ITGAL, CLDN20, CLDN7, CDH1, CD40, F11R, CD22, CLDN4, PTPRM, OCLN, ITGB1",0.0545314148681803,0,FALSE
+"H2126","Input","KEGG_CELL_CYCLE",-0.46269,-1.61,0.0347,16390,0.664,"GSK3B, MAD2L2, TTK, CCNA1, TFDP1, PTTG2, YWHAE, CCNE2, CDC20, MAD1L1, MCM5, CDKN1A, CDC25C, E2F2, MCM3, ANAPC13, TFDP2, E2F3, MCM2, RBL1, PRKDC, SKP1, PKMYT1, CCNH, MCM6, CDKN2B, TP53, CDK6, MAD2L1, CDKN2D, BUB1, CDKN2A, YWHAQ, CDC14A, GADD45A, CCNB2, CDKN1C, CDKN2C, PLK1, HDAC2, CDK1, CCNA2, CDC25A, MCM4, CDC7, ORC3, HDAC1, ORC6, BUB3, PTTG1, CDK4, CCNB1, SMC3, TGFB1",1.45967052520913,0.177831920631982,FALSE
+"H2126","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.24171,0.711,0.875,4024,1,"CCL22, ADCY5, CCR7, CCL17, ADCY4, ARRB1, VAV1, JAK3, STAT3, CCR3, ARRB2, IKBKB, RELA, CXCL16, WASL, GRK2, SOS2, ADCY6, PIK3R3, STAT2, AKT1, CXCL3, VAV2, MAPK3, PREX1, STAT5B, CXCL2, PRKCD, ROCK1, IKBKG, CCL28, SOS1, TIAM1",0.0579919469776868,0,FALSE
+"H2126","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.32338,-1.15,0.25,16866,0.566,"CDKN1A, PIK3R1, RAF1, E2F2, SHC2, E2F3, TP53, CDK6, CDKN2A, MECOM, BAD, HDAC2, HRAS, NRAS, AKT3, HDAC1, CDK4, TGFB1",0.602059991327962,0.247183568811729,FALSE
+"H2126","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.57486,1.68,0.0148,5204,0.417,"CSNK1E, PER2, CSNK1D, NPAS2, CLOCK, CRY1, BHLHE40, BHLHE41",1.82973828460504,0.379863945026242,FALSE
+"H2126","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.28756,0.845,0.708,4824,1,"SUCLG2, IDH3G, PC, IDH2, IDH3B, DLAT, SDHA, DLST, ACO2, SDHD, MDH2, PDHA1, IDH1",0.149966742310231,0,FALSE
+"H2126","Input","KEGG_COLORECTAL_CANCER",-0.27994,-0.952,0.45,15119,0.667,"RAC1, PIK3CD, MSH6, MAP2K1, MLH1, SMAD3, TGFB3, GSK3B, LEF1, MAPK10, BIRC5, PIK3R1, RAF1, RHOA, TP53, BCL2, JUN, TCF7, BAD, AKT3, TGFB1",0.346787486224656,0.175874166083451,FALSE
+"H2126","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.45314,1.33,0.109,1849,0.779,"FGA, BDKRB2, FGG, FGB, BDKRB1, CD55, C8G, PLG, TFPI",0.962573502059376,0.108462542327436,FALSE
+"H2126","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.259,0.76,0.812,1369,1,"LDHC, TAT, CTH, AHCYL1",0.0904439707588247,0,FALSE
+"H2126","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.19403,0.575,0.983,4429,1,"CCL22, CCR7, CCL17, INHBB, EPO, TNFSF11, IFNL3, IL9R, TNFRSF18, IL13RA1, TGFBR1, CCR3, BMP7, CXCL16, CSF2RB, GH2, PDGFB, CD40, TNFRSF25, TNFSF13, TNFSF15, CLCF1, EPOR, CXCL3, LTBR, KITLG, VEGFC, CXCL2, OSMR, IL20RA, IL1R1, CCL28, TNFRSF1B, VEGFA, TNFRSF1A, VEGFD, IFNL2, TPO",0.00744648216786438,0,FALSE
+"H2126","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.2581,0.748,0.833,4933,1,"RIPK3, IRF3, IKBKB, RELA, ADAR, POLR3F, POLR3GL, TBK1, IKBKG, MAVS, CCL5, NFKBIB",0.0793549985932124,0,FALSE
+"H2126","Input","KEGG_DILATED_CARDIOMYOPATHY",0.273,0.799,0.76,2736,1,"ADCY5, CACNB2, CACNG1, TNNI3, ADCY4, CACNA1D, ITGB6, ITGB5, ITGA1, ADCY6, CACNG6, ITGA2B",0.119186407719209,0,FALSE
+"H2126","Input","KEGG_DNA_REPLICATION",-0.6495,-2.4,0,16205,0.0669,"POLE3, PCNA, RPA2, POLE, RFC1, MCM5, PRIM1, POLA2, POLA1, MCM3, RPA3, RNASEH2C, RFC5, MCM2, MCM6, RFC4, RFC2, FEN1, MCM4, PRIM2",Inf,1.17457388223218,TRUE
+"H2126","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43235,1.27,0.153,4847,0.713,"PIWIL2, ETS2, SPIRE2, NOTCH3, SOS2, MAPK3, SOS1, MAPK1, ETV7",0.815308569182401,0.146910470148134,FALSE
+"H2126","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.42313,1.27,0.147,3429,0.713,"GSTA3, ALDH3B2, GSTK1, ALDH3B1, CYP2A7, CYP2A6, CYP2D6, GSTM5, GSTZ1, GSTA4, GSTO2, GSTM3, MGST1, FMO5, ALDH1A3",0.832682665251824,0.146910470148134,FALSE
+"H2126","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.35672,1.04,0.369,1174,1,"CES1, TYMP, CYP2A7, GUSB, CYP2A6",0.43297363384094,0,FALSE
+"H2126","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.24668,-0.859,0.646,14988,0.787,"COL4A4, GP1BB, ITGA7, ITGA9, COL11A1, ITGA11, RELN, COL5A3, COL6A3, THBS2, COL3A1, LAMA4, ITGAV, COL11A2, ITGB3, THBS1, COL1A2, COL4A6, SPP1, ITGA4, LAMA1, ITGB8, LAMA2, COL4A2, COL5A2, THBS4, SV2A, COL5A1, ITGA6, SDC2, FN1, TNC, COL6A2, HMMR, COL4A1",0.189767482004916,0.104025267640935,FALSE
+"H2126","Input","KEGG_ENDOCYTOSIS",0.30523,0.903,0.604,3795,1,"CHMP1B, HSPA1L, ARFGAP3, PLD1, ARRB1, CHMP2A, ARFGAP1, USP8, PLD2, RAB11B, STAM2, ARRB2, CBLC, CHMP5, VPS45, EPN3, PIP5K1B, SMURF1, IQSEC2, VPS36, GRK2, ARAP2, SH3GLB2, AP2A1, TFRC, IGF1R, VPS28, CHMP3, RAB11FIP4, RAB31, ERBB3, HSPA1A, WWP1, PSD4, RAB5B, FGFR3, VPS37C, ASAP2, HSPA1B, CHMP2B, HSPA2, ITCH, CHMP4B",0.218963061378868,0,FALSE
+"H2126","Input","KEGG_ENDOMETRIAL_CANCER",-0.21223,-0.721,0.852,15187,0.934,"PIK3CD, FOXO3, MAP2K1, MLH1, EGF, GSK3B, ELK1, LEF1, PIK3R1, RAF1, TP53, TCF7, BAD, HRAS, NRAS, AKT3",0.0695604052332999,0.0296531237699066,FALSE
+"H2126","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.19245,0.57,0.982,5904,1,"ATP6V1B1, ATP6V0A4, ATP6AP1, IKBKB, RELA, TCIRG1, PLCG2, MAPK13, F11R, ATP6V0B, ADAM10, IKBKG, ATP6V0E2, ATP6V1G1, MAPK11, CCL5, PAK1, ATP6V1F, ATP6V1E2, IGSF5, NFKBIA, ADAM17, EGFR",0.00788851221305034,0,FALSE
+"H2126","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.18735,0.553,0.984,4693,1,"GAB1, CBLC, ERBB2, BTC, CAMK2G, SOS2, PAK4, PAK6, PLCG2, PIK3R3, ERBB3, AKT1, MAP2K7, MAPK3, STAT5B, SOS1, PRKCG, MTOR, MAPK1, NRG4, AREG",0.00700490156865849,0,FALSE
+"H2126","Input","KEGG_ETHER_LIPID_METABOLISM",0.49491,1.46,0.064,4713,0.587,"PLA2G6, PLD1, PAFAH2, PLD2, PLA2G12A, PLA2G10, PLPP3, PLA2G2D, PLA2G2C, PLA2G4A, PAFAH1B2, PLA2G4B, LPCAT1",1.19382002601611,0.231361898752386,FALSE
+"H2126","Input","KEGG_FATTY_ACID_METABOLISM",0.3501,1.03,0.414,4233,1,"CYP4A22, CPT1B, ACADM, ACSL1, CPT2, ACSL3, ACOX3, ACADS, ALDH2, ALDH3A2, ACAA1, CPT1C, HADHB",0.382999658879101,0,FALSE
+"H2126","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.27487,0.803,0.748,4709,1,"PLA2G6, VAV1, PLA2G12A, PLA2G10, SOS2, PLCG2, PLA2G2D, PIK3R3, MAPK13, AKT1, MAP2K7, PLA2G2C, VAV2, MAPK3, PRKCD, PLA2G4A, SOS1, MAPK1, PLA2G4B, VAV3, MAPK11",0.126098402135539,0,FALSE
+"H2126","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.22207,0.648,0.936,4703,1,"PLA2G6, PLD1, VAV1, PLD2, PIP5K1B, PLPP3, WASL, ARPC1A, PLCG2, PIK3R3, AKT1, ARPC1B, VAV2, ASAP2, MAPK3, VASP, PRKCD, PLA2G4A, PRKCG, MYO10, MAPK1, PLA2G4F, WASF3, PLA2G4B, VAV3",0.0287241512618947,0,FALSE
+"H2126","Input","KEGG_FOCAL_ADHESION",-0.27255,-0.997,0.419,14988,0.613,"COL4A4, ITGA7, ITGA9, RAC1, PIK3CD, COL11A1, CAV1, ACTN2, ITGA11, MAP2K1, RELN, EGF, COL5A3, SHC4, PGF, COL6A3, PDGFRA, THBS2, MYLK2, PRKCA, COL3A1, LAMA4, MYLPF, CCND2, SHC3, ITGAV, PAK3, MYL5, GSK3B, COL11A2, ITGB3, DOCK1, THBS1, PDGFRB, COL1A2, ELK1, COL4A6, SPP1, ITGA4, MAPK10, LAMA1, ITGB8, PIK3R1, RAF1, LAMA2, COL4A2, SHC2, VCL, FLNC, COL5A2, THBS4, CDC42, PARVA, COL5A1, RHOA, PPP1CC, MYL9, ITGA6, BCL2, JUN, MYLK, FN1, TNC, VEGFB, COL6A2, ACTN1, BAD, ACTG1, COL4A1, HRAS, PDGFC, AKT3, ACTB, FYN, FLNA",0.377785977033705,0.212539525481585,FALSE
+"H2126","Input","KEGG_FOLATE_BIOSYNTHESIS",0.37341,1.11,0.291,3757,0.92,"PTS, GCH1, SPR, QDPR",0.536107011014093,0.0362121726544447,FALSE
+"H2126","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.33426,0.99,0.472,3315,1,"GMPPA, FBP1, HK2, FPGT, PHPT1, GMDS, PFKFB2, GMPPB",0.326058001365912,0,FALSE
+"H2126","Input","KEGG_GALACTOSE_METABOLISM",0.38366,1.13,0.271,5813,0.931,"HK2, B4GALT1, GAA, GALK2, PGM1, B4GALT2, GLA, MGAM, PGM2, GLB1, UGP2, GALT, G6PC2, GALE",0.567030709125594,0.0310503190186574,FALSE
+"H2126","Input","KEGG_GAP_JUNCTION",-0.29855,-1.05,0.296,15131,0.667,"TUBA4A, DRD2, GNAI3, PLCB3, MAP2K1, EGF, PDGFRA, MAPK7, GUCY1A2, PRKCA, PRKG1, GUCY1A1, MAP3K2, PDGFRB, TUBB4A, ADCY1, RAF1, PRKACA, GUCY1B1, TUBB4B, TUBA1B, GJA1, TUBB2B, GNAI1, TUBA1A, HRAS, CDK1, NRAS, PDGFC, TUBB, ADCY7, TUBB6, GNAI2, TUBB2A",0.528708288941061,0.175874166083451,FALSE
+"H2126","Input","KEGG_GLIOMA",-0.27635,-0.985,0.388,15187,0.616,"PIK3CD, MAP2K1, EGF, SHC4, PDGFRA, PRKCA, SHC3, PDGFRB, CDKN1A, PIK3R1, RAF1, E2F2, SHC2, E2F3, TP53, CDK6, CDKN2A, HRAS, CALM2, NRAS, AKT3, CDK4",0.411168274405793,0.210419287835575,FALSE
+"H2126","Input","KEGG_GLUTATHIONE_METABOLISM",0.38098,1.12,0.286,3980,0.947,"GSTA3, GSTK1, TXNDC12, G6PD, GSTM5, GSTZ1, OPLAH, GSTA4, GSTO2, GSTM3, GCLC, MGST1, GPX2, IDH2, GSR, MGST2, GPX3",0.543633966870957,0.0236500209967266,FALSE
+"H2126","Input","KEGG_GLYCEROLIPID_METABOLISM",0.26236,0.762,0.814,5940,1,"AKR1A1, DGAT1, PLPP3, TKFC, DGKE, MBOAT1, DGAT2, ALDH2, ALDH3A2, GLA, LCLAT1, GPAT4, DGKQ, AGPAT4, MGLL, GPAT2, PLPP2, AGK",0.0893755951107988,0,FALSE
+"H2126","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40279,1.19,0.209,4713,0.87,"PISD, LPGAT1, PLA2G6, PLD1, CHKB, PLD2, PLA2G12A, CDS1, PLA2G10, PLPP3, PEMT, PLA2G2D, CRLS1, DGKE, MBOAT1, PLA2G2C, PLA2G4A, LCLAT1, GPAT4, DGKQ, PTDSS2, PLA2G4B, AGPAT4, LPCAT1",0.679853713888946,0.0604807473813815,FALSE
+"H2126","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.395,1.14,0.272,5552,0.99,"AGXT, AOC2, CTH, AOC3, DMGDH, GATM, MAOA, AMT, SRR, GAMT, DLD, GCAT",0.565431095965801,0.00436480540245009,FALSE
+"H2126","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.2415,0.711,0.882,5481,1,"ALDH3B2, ALDH3B1, LDHC, AKR1A1, FBP1, HK2, PGM1, GALM, ACSS2, PGAM2, ALDH2, ALDH1A3, ALDH3A2, DLAT, BPGM, PDHA1, PGM2, PGK2, LDHA, DLD, LDHAL6B",0.0545314148681803,0,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.27556,0.8,0.77,5075,1,"CSGALNACT1, XYLT1, B4GALT7, CHST11, CHST15, CHST12, XYLT2, CHSY1, CHPF",0.113509274827518,0,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.29535,0.848,0.688,2944,1,"XYLT1, HS6ST1, HS6ST2, HS6ST3, B4GALT7",0.162411561764489,0,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.50905,1.52,0.0412,2407,0.459,"B3GNT7, B4GALT4, ST3GAL1, B4GALT1, B3GNT2, CHST6",1.38510278396687,0.338187314462739,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.60147,1.79,0.00925,5672,0.661,"HGSNAT, NAGLU, HYAL1, IDUA, GUSB, HYAL4, GNS, HYAL2, GALNS, IDS, HEXB, GLB1, HPSE",2.03385826726097,0.17979854051436,FALSE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.23299,0.689,0.902,5605,1,"ST3GAL1, B3GALT4, SLC33A1, ST6GALNAC4, HEXB, GLB1",0.0447934624580583,0,FALSE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.45542,1.33,0.112,5491,0.779,"FUT2, ST3GAL1, NAGA, GBGT1, A4GALT, GLA, HEXB, FUT1",0.950781977329818,0.108462542327436,FALSE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.53373,1.56,0.0333,2364,0.485,"B4GALT4, ST3GAL4, FUT2, FUT3, B3GNT3, B4GALT1, ABO, B3GNT2",1.47755576649368,0.314258261397736,FALSE
+"H2126","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.54041,1.59,0.0366,4759,0.458,"PIGO, PIGT, PIGF, PIGU, DPM2, GPAA1, PIGL, PIGH, PIGZ, PIGV, PIGK, GPLD1, PIGS, PIGB, PIGP",1.43651891460559,0.339134521996131,FALSE
+"H2126","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.24867,0.727,0.858,5325,1,"MTHFD2L, AFMID, ACO2, MTHFD2, MDH2, GRHPR",0.0665127121512946,0,FALSE
+"H2126","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.35081,1.03,0.396,4746,1,"ADCY5, CGA, MAP3K4, ADCY4, PLA2G6, PLD1, CALML6, ITPR1, CACNA1D, PLD2, PLA2G12A, PLA2G10, CAMK2G, SOS2, ADCY6, ATF4, PLA2G2D, MAPK13, MAP2K7, PLA2G2C, MAPK3, PRKCD, PLA2G4A, SOS1, PLCB1, MAPK1, CACNA1F, GNAQ, PLA2G4B, MAPK11, LHB",0.402304814074488,0,FALSE
+"H2126","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.49648,-1.74,0.00787,10721,0.598,"KIR2DL1, CD28, KIR3DL2, IL2, KLRC1, KIR3DL1, KIR2DL3, FASLG, CD80, IL6, PRF1, CD86, TNF, GZMB, IL1A, IL1B, FAS",2.10402526764094,0.223298816011589,FALSE
+"H2126","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.37973,1.11,0.282,1742,0.92,"WNT3A, CSNK1E, WNT4, WNT7B, BMP6, WNT11, BMP7, BMP8B",0.549750891680639,0.0362121726544447,FALSE
+"H2126","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.32319,0.951,0.543,5962,1,"CD38, CD14, EPO, CD4, IL9R, CD55, ITGA1, TFRC, ITGA2B, EPOR, CD22, KITLG, CD19, IL1R1, GP1BA, TPO, CD37, CD5, IL1R2, IL4R, CD59, DNTT, IL7, FCGR1A, ITGA3",0.265200170411153,0,FALSE
+"H2126","Input","KEGG_HISTIDINE_METABOLISM",0.52547,1.54,0.0431,636,0.451,"HAL, AMDHD1, ALDH3B2, ALDH3B1, BUD23",1.36552272983927,0.345823458122039,FALSE
+"H2126","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.27595,0.813,0.766,7114,1,"RAD52, BLM, POLD4, MRE11, SEM1, XRCC3, NBN, TOP3B, BRCA2, EME1, RAD50, RAD54B, MUS81, XRCC2, POLD3, RAD51D",0.115771230367396,0,FALSE
+"H2126","Input","KEGG_HUNTINGTONS_DISEASE",-0.28479,-1.02,0.381,16178,0.684,"NDUFB3, CLTB, DNALI1, DNAH1, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, DCTN4, VDAC2, NDUFB8, ATP5F1C, NDUFA9, NDUFAB1, SDHB, TFAM, POLR2D, AP2S1, COX4I1, TP53, BDNF, AP2M1, UQCRC1, NDUFB5, NDUFA1, CREB5, CLTA, HDAC2, ATP5MC3, ATP5PF, NDUFS3, COX8A, BBC3, ATP5PO, IFT57, HDAC1, NDUFS4, NDUFB6, TBPL1, ATP5F1A, HIP1, POLR2E, GPX1",0.419075024324381,0.164943898279884,FALSE
+"H2126","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.28411,0.826,0.709,2736,1,"CACNB2, CACNG1, PRKAB1, TNNI3, PRKAG1, PRKAA2, CACNA1D, ITGB6, ITGB5, ITGA1, CACNG6, ITGA2B",0.149353764816933,0,FALSE
+"H2126","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.24748,0.726,0.865,4850,1,"OCRL, ALDH6A1, INPP4A, PIP4K2C, PIP5K1B, ITPK1, PLCG2, PI4KB, INPP5B, INPPL1, INPP5K, IMPA2, PLCB1, PIK3C2A, IPMK",0.0629838925351858,0,FALSE
+"H2126","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.35765,1.06,0.354,4207,0.99,"PRKAB1, IRS2, INS, PHKA1, PPP1R3B, PRKAG1, GYS1, CALML6, FBP1, HK2, PRKAA2, PTPRF, MKNK1, CBLC, PPP1R3D, IKBKB, SOCS2, TSC1, ACACB, PHKA2, SOS2, SREBF1, PPP1R3C, PIK3R3, PYGL, AKT1, RPTOR, FOXO1, FASN, ACACA, MAPK3, SOCS4, MKNK2, PRKAB2, PHKG1, PRKAA1, SOS1, INPP5K, MTOR",0.450996737974212,0.00436480540245009,FALSE
+"H2126","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.23361,-0.809,0.653,15219,0.857,"MAP3K14, CXCL12, CCL27, IL15, CXCR4, ITGA4, CCR10, MADCAM1, TGFB1",0.185086818724926,0.0670191780768018,FALSE
+"H2126","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27339,0.805,0.755,4429,1,"EPO, SPRY3, IFNL3, JAK1, JAK3, IL9R, IL13RA1, STAT3, PIAS3, STAM2, CBLC, SOCS2, CSF2RB, SOS2, GH2, PTPN6, PIK3R3, SOCS7, STAT2, TYK2, AKT1, CLCF1, EPOR, STAT5B, SOCS4, EP300, OSMR, IL20RA, SOS1, IFNL2, STAT6, TPO",0.122053048370812,0,FALSE
+"H2126","Input","KEGG_LEISHMANIA_INFECTION",0.23567,0.68,0.912,3758,1,"NCF4, ITGB2, JAK1, IRAK4, RELA, PTPN6, MAPK13, TAB1, MAPK3, MYD88, ITGB1",0.0400051616715838,0,FALSE
+"H2126","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.25033,0.737,0.851,5306,1,"CDH5, NCF4, ITGB2, VAV1, RAPGEF4, RAPGEF3, CLDN3, CTNND1, ITGAL, CLDN20, CLDN7, PLCG2, PIK3R3, TXK, MAPK13, ARHGAP35, F11R, VAV2, CLDN4, VASP, RASSF5, OCLN, ROCK1, ITGB1, SIPA1, PRKCG, CLDN9, VAV3, MAPK11, PXN, CTNNA1, AFDN, CLDN8, CYBB",0.0700704399154121,0,FALSE
+"H2126","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.41231,-1.47,0.0486,17832,0.557,"ALDH1B1, ECHS1, ALDH9A1",1.31336373073771,0.254144804826271,FALSE
+"H2126","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.45089,1.32,0.115,5251,0.742,"PLA2G6, PLA2G12A, CYP2J2, PLA2G10, PLA2G2D, PLA2G2C, PLA2G4A, CYP3A43, PLA2G4B, ALOX15, CYP3A7",0.939302159646388,0.129596094720973,FALSE
+"H2126","Input","KEGG_LONG_TERM_DEPRESSION",0.28697,0.84,0.704,4629,1,"PLA2G6, RYR1, ITPR1, PLA2G12A, PLA2G10, PRKG2, IGF1R, GNAO1, PLA2G2D, CACNA1A, PLA2G2C, MAPK3, PPP2R1B, PLA2G4A, PRKCG, PLCB1, MAPK1, GNAQ, PLA2G4B",0.152427340857888,0,FALSE
+"H2126","Input","KEGG_LONG_TERM_POTENTIATION",0.24903,0.735,0.86,4541,1,"GRIN2D, GRIN1, CALML6, ITPR1, RPS6KA2, RPS6KA6, RAPGEF3, CAMK2G, ATF4, MAPK3, EP300, PRKCG, PLCB1, MAPK1, GNAQ",0.0655015487564323,0,FALSE
+"H2126","Input","KEGG_LYSINE_DEGRADATION",0.23752,0.7,0.895,3759,1,"SETDB1, SETD7, EHMT1, KMT5B, ASH1L, KMT5C, AASDH, ALDH2, ALDH3A2, AASDHPPT",0.048176964684088,0,FALSE
+"H2126","Input","KEGG_LYSOSOME",0.4666,1.35,0.0936,5816,0.787,"SLC11A1, HGSNAT, PPT1, GM2A, CTSL, NAGLU, ARSA, FUCA1, HYAL1, ATP6V0A4, IDUA, GUSB, SLC11A2, CLN3, ATP6AP1, LGMN, AP3S2, NAGA, CTSA, GGA1, AP4M1, AGA, GAA, GALC, LAMP1, GNPTG, ASAH1, SLC17A5, GNS, TCIRG1, CTSH, DNASE2, CD63, CTSF, LAPTM4A, MFSD8, CTSD, AP1M2, ARSG, AP1G1, ATP6V0B, MAN2B1, CLN5, GALNS, LIPA, LAMP3, GLA, SORT1, AP3M1, NPC1, AP3D1, IDS, GGA3, NAGPA, CD68, ACP2, PSAP, MANBA, HEXB, GBA, CTSC, GLB1, ABCA2, CTSS, LAMP2, AP3B1",1.02872415126189,0.104025267640935,FALSE
+"H2126","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26325,0.768,0.813,4631,1,"CACNB2, CACNG1, CACNA1I, CD14, MAP3K4, HSPA1L, PLA2G6, ARRB1, DUSP16, NR4A1, RPS6KA2, TGFBR1, TRAF2, CACNA1D, FGF12, MAP3K8, PLA2G12A, RPS6KA6, FGF19, DUSP8, ARRB2, MKNK1, IKBKB, RELA, MAPK8IP2, PLA2G10, GADD45B, DUSP4, SOS2, ATF4, MAP3K5, FGF11, PDGFB, CACNG6, PLA2G2D, RASGRP3, MAPK13, AKT1, TAOK1, CACNA1A, RPS6KA5, MAP4K3, HSPA1A, MAP2K7, TAB1, PLA2G2C, FGFR3, MAP3K11, MAPK3, HSPA1B, STK3, MKNK2, HSPA2, TAOK3, IL1R1, IKBKG, PLA2G4A, DUSP1, MAPKAPK2, SOS1, RRAS, PRKCG, MAPK1, TNFRSF1A, CACNG8, NLK, CACNG4, CACNA1F, PLA2G4B, GADD45G",0.0899094544059319,0,FALSE
+"H2126","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.31047,0.919,0.586,1738,1,"INS, BHLHA15, FOXA3",0.232102383981909,0,FALSE
+"H2126","Input","KEGG_MELANOGENESIS",0.32653,0.956,0.514,1246,1,"WNT3A, FZD10, ADCY5, MC1R, ADCY4, WNT4, CREB3L4, CALML6, WNT7B, WNT11",0.289036881004724,0,FALSE
+"H2126","Input","KEGG_MELANOMA",-0.3336,-1.16,0.272,15187,0.609,"PIK3CD, FGF18, MAP2K1, EGF, PDGFRA, FGFR1, FGF5, PDGFRB, FGF13, CDKN1A, FGF1, PIK3R1, RAF1, E2F2, FGF22, E2F3, TP53, CDK6, CDKN2A, FGF2, BAD, HRAS, NRAS, PDGFC, AKT3, CDK4",0.565431095965801,0.215382707367125,FALSE
+"H2126","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41418,1.21,0.193,4313,0.847,"GSTA3, ALDH3B2, GSTK1, ALDH3B1, CYP1B1, GSTM5, GSTZ1, GSTA4, GSTO2, GSTM3, MGST1, ALDH1A3, AKR1C2, MGST2, DHDH, CYP2F1, CYP3A43",0.714442690992226,0.0721165896692931,FALSE
+"H2126","Input","KEGG_MISMATCH_REPAIR",-0.37099,-1.32,0.15,14311,0.719,"RPA1, POLD2, RFC3, MSH6, MLH1, PCNA, RPA2, RFC1, RPA3, RFC5, RFC4, RFC2",0.823908740944319,0.143271109617117,FALSE
+"H2126","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.43345,1.27,0.149,4516,0.713,"INS, CAB39, RPS6KA2, RICTOR, PRKAA2, RPS6KA6, TSC1, PIK3R3, CAB39L, AKT1, RPTOR, MAPK3, VEGFC, PRKAA1, ULK3, VEGFA, MTOR, EIF4B, MAPK1, VEGFD, ULK1",0.826813731587726,0.146910470148134,FALSE
+"H2126","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.14128,-0.486,1,12416,0.998,"IFNA13, RAET1G, HCST, CHP2, PLCG1, ICAM1, IFNA21, PPP3CB, IFNGR1, PRKCB, PRF1, NFAT5, IFNA8, PPP3CC, PIK3CG, TNFRSF10C, IFNA1, CD247, TNF, IFNA5, CASP3, IFNB1, GZMB, PPP3R2, LCK, NFATC1, RAC1, PIK3CD, MAP2K1, ULBP1, SHC4, RAET1L, PRKCA, CSF2, SHC3, PPP3R1, ICAM2, PIK3R1, RAF1, TNFRSF10B, NFATC2, SHC2, FAS, ULBP2, ULBP3, HRAS, MICB, NRAS, FYN",0,0.000869458712628891,FALSE
+"H2126","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34377,1.01,0.418,2843,1,"VIPR2, BDKRB2, GHSR, GALR3, P2RY6, CGA, MLNR, BDKRB1, MC1R, SSTR1, F2RL3, P2RX4, GRIN2D, ADORA1, GRIN1, ADRA1D, TRPV1, PTAFR, S1PR4, GABRR2, P2RX2, GABRA3, GABRB3, P2RY2, PLG, GLP2R, DRD4, GH2, LTB4R2, OPRL1, TACR3, LTB4R, TRHR, GRM3",0.378823718224965,0,FALSE
+"H2126","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.20862,-0.725,0.872,14936,0.952,"NTRK2, NTRK3, RAC1, IRAK3, PIK3CD, FOXO3, MAPK14, MAP2K1, SHC4, YWHAG, KIDINS220, MAPK7, NTF3, SHC3, GSK3B, NGF, NGFR, RPS6KA4, YWHAE, NFKBIE, CSK, MAPK10, TP73, PIK3R1, RAF1, IRS1, SHC2, CAMK4, CDC42, RHOA, TP53, BDNF, BCL2, JUN, YWHAQ, SH2B3, BAD, HRAS, CALM2, NRAS, AKT3, ARHGDIA, MAP3K3",0.0594835150674328,0.0213630516155257,FALSE
+"H2126","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38503,1.13,0.276,2820,0.931,"CD38, NADK, NADSYN1, NT5C2, NMRK1, NAMPT, NMNAT1",0.559090917934782,0.0310503190186574,FALSE
+"H2126","Input","KEGG_NITROGEN_METABOLISM",0.42711,1.25,0.149,1139,0.756,"HAL, GLUL, CTH",0.826813731587726,0.121478204498793,FALSE
+"H2126","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.25334,0.746,0.859,6235,1,"NOD2, TAB3, XIAP, IKBKB, RELA, MAPK13, BIRC3, TAB1, MAPK3, CXCL2, IKBKG, CARD8, BIRC2, MAPK1, MAPK11, CCL5, NFKBIB, NFKBIA, CASP8, ERBIN, CASP1, MAPK12, NLRP1",0.0660068361687577,0,FALSE
+"H2126","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.41668,-1.51,0.0611,17589,0.726,"PRKDC, XRCC5, XRCC4, FEN1, NHEJ1",1.21395878975745,0.139063379299906,FALSE
+"H2126","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.24966,-0.893,0.56,17114,0.777,"PIK3R1, RAF1, E2F2, E2F3, TP53, CDK6, CDKN2A, BAD, HRAS, NRAS, AKT3, CDK4",0.2518119729938,0.109578981199086,FALSE
+"H2126","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.23814,0.693,0.903,4437,1,"NUMB, MAML3, APH1A, RFNG, NOTCH3, PSEN1, DTX1, KAT2A, EP300, DVL1, CTBP1, PSENEN, DTX3",0.0443122496864942,0,FALSE
+"H2126","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.32406,-1.15,0.239,16205,0.566,"POLE3, PCNA, RPA2, POLE, RFC1, GTF2H1, RPA3, RFC5, ERCC8, CCNH, GTF2H3, RFC4, RFC2",0.621602099051862,0.247183568811729,FALSE
+"H2126","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.57278,1.7,0.0194,4082,0.44,"MGAT4A, DPAGT1, MAN2A2, ST6GAL1, MOGS, RPN2, ALG2, MGAT5B, ALG13, STT3A, MAN1B1, B4GALT1, DPM2, ALG6, ALG8, ALG3, DOLPP1, ALG12, ALG10B, ALG11, RPN1, DDOST, ALG5, B4GALT2, DPM3",1.71219827006977,0.356547323513813,FALSE
+"H2126","Input","KEGG_OLFACTORY_TRANSDUCTION",0.26721,0.794,0.757,2307,1,"OR1I1, OR10H2, OR6Q1, OR1F1, OR8B8, OR2A14, OR52B4, GUCA1B, OR6B1, OR10AD1, CALML6, OR52K1, OR2A12, GUCY2D, ARRB2, CNGB1, PRKG2, OR10A3, CAMK2G, OR11H1, OR2A2",0.120904120499927,0,FALSE
+"H2126","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.3714,-1.36,0.137,17549,0.72,"SHMT2, TYMS, MTR, DHFR",0.863279432843593,0.142667503568732,FALSE
+"H2126","Input","KEGG_OOCYTE_MEIOSIS",0.22124,0.652,0.92,2630,1,"ADCY5, ADCY4, SMC1B, INS, CALML6, ANAPC2, ITPR1, RPS6KA2, RPS6KA6, SLK, CDC16, CAMK2G, ADCY6, IGF1R, STAG3, ANAPC5",0.0362121726544447,0,FALSE
+"H2126","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.65357,1.91,0.00462,5781,0.585,"FUCA1, MAN2C1, AGA, MAN2B2, ENGASE, MAN2B1, MANBA, HEXB, GBA, GLB1, NEU3",2.33535802444387,0.23284413391782,FALSE
+"H2126","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.28498,-1.01,0.398,15908,0.631,"COX7C, ATP5MF, NDUFB3, NDUFA11, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, ATP6V1G2, NDUFB8, ATP6V0A2, ATP6V0D1, ATP5F1C, NDUFA9, NDUFAB1, PPA1, SDHB, COX4I1, UQCRC1, NDUFB5, NDUFA1, ATP6V1A, ATP6V0E1, ATP5MC3, ATP5PF, ATP6V1B2, NDUFS3, COX8A, ATP5PO, NDUFS4, NDUFB6, ATP5F1A, ATP6V1H",0.400116927926312,0.199970640755866,FALSE
+"H2126","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.44008,1.29,0.128,3870,0.82,"GCNT3, GALNT6, GALNT12, B3GNT6, ST3GAL1, ST6GALNAC1, GALNT3, GALNT14, GALNT4, C1GALT1C1, C1GALT1, GALNT7, GALNT10",0.892790030352132,0.0861861476162833,FALSE
+"H2126","Input","KEGG_P53_SIGNALING_PATHWAY",-0.35516,-1.29,0.138,15946,0.713,"CCND2, COP1, PMAIP1, RRM2, THBS1, PPM1D, CCNE2, CDKN1A, SESN1, TP73, TNFRSF10B, SERPINE1, FAS, SESN3, TP53, CDK6, STEAP3, CDKN2A, GADD45A, CCNB2, SESN2, CDK1, BBC3, CDK4, CCNG1, CCNB1",0.860120913598763,0.146910470148134,FALSE
+"H2126","Input","KEGG_PANCREATIC_CANCER",0.23745,0.695,0.899,4562,1,"CASP9, JAK1, PLD1, TGFBR1, STAT3, IKBKB, RELA, ERBB2, PIK3R3, AKT1, MAPK3, VEGFC, SMAD2, IKBKG, VEGFA, RALBP1, MAPK1, VEGFD, RALB",0.0462403082667712,0,FALSE
+"H2126","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3343,0.987,0.454,5018,1,"PPCS, BCAT2, COASY, PPCDC, ENPP1, PANK2",0.342944147142896,0,FALSE
+"H2126","Input","KEGG_PARKINSONS_DISEASE",-0.20922,-0.756,0.853,15759,0.921,"UBE2J2, NDUFB10, COX7C, HTRA2, NDUFB3, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, VDAC2, NDUFB8, ATP5F1C, NDUFA9, NDUFAB1, SDHB, COX4I1, UQCRC1, NDUFB5, NDUFA1, ATP5MC3, ATP5PF, NDUFS3, COX8A, ATP5PO, NDUFS4, NDUFB6, ATP5F1A",0.069050968832477,0.0357403698031511,FALSE
+"H2126","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.4175,-1.47,0.089,16563,0.557,"ARHGEF2, TLR4, TUBB4A, LY96, TUBB4B, ARPC5L, NCL, CDC42, RHOA, TUBA1B, YWHAQ, TUBB2B, TUBA1A, ACTG1, ARPC4, TUBB, ARPC2, TUBB6, ACTB, FYN, TUBB2A",1.05060999335509,0.254144804826271,FALSE
+"H2126","Input","KEGG_PATHWAYS_IN_CANCER",0.1848,0.546,0.992,4372,0.996,"WNT3A, FZD10, CASP9, ARNT2, JAK1, WNT4, PLD1, TRAF4, EPAS1, WNT7B, TGFBR1, TRAF2, STAT3, PIAS3, FGF12, WNT11, FGF19, CBLC, XIAP, IKBKB, EGLN2, RELA, ARNT, ERBB2, RXRA, SOS2, IGF1R, FGF11, PDGFB, PLCG2, PIK3R3, CDH1, ITGA2B, BAX, JUP, LAMA3, AKT1, BIRC3, LAMA5, FOXO1, FGFR3, KITLG, MAPK3, STAT5B, VEGFC, RASSF5, EP300, ITGB1, WNT9A, SMAD2, IKBKG, DVL1, CTBP1, SOS1, PRKCG, VEGFA, MTOR, RALBP1, BIRC2, BID, MAPK1, VEGFD",0.00348832784582135,0.00174066157630127,FALSE
+"H2126","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.32989,0.967,0.477,6463,1,"GUSB, UGDH, DHDH, CRYL1, UGP2, DCXR, RPEL1",0.321481620959886,0,FALSE
+"H2126","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.39083,1.17,0.218,5330,0.919,"G6PD, FBP1, PRPS1, TKTL1, H6PD, PGM1, PRPS1L1, PRPS2, TKT, PGLS, PGM2, PGD, RBKS",0.661543506395395,0.0366844886138887,FALSE
+"H2126","Input","KEGG_PEROXISOME",0.39474,1.16,0.246,4935,0.933,"AGXT, PEX11A, GSTK1, ECH1, PEX1, ABCD1, ACSL1, SLC27A2, ACSL3, SCP2, PXMP4, ACOX3, PEX11G, AMACR, PEX12, PEX2, CROT, PEX11B, PEX13, ABCD4, EPHX2, HMGCL, IDH2, ACAA1, PEX7, XDH, PMVK, MPV17, NUDT19, MLYCD, CRAT, IDH1, PEX26, SLC25A17",0.609064892896621,0.0301183562535,FALSE
+"H2126","Input","KEGG_PHENYLALANINE_METABOLISM",0.55039,1.62,0.0311,4471,0.439,"ALDH3B2, ALDH3B1, AOC2, TAT, AOC3, ALDH1A3, NAA80, MAOA",1.50723961097316,0.357535479757879,FALSE
+"H2126","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.27493,0.798,0.758,4316,1,"OCRL, CALML6, ITPR1, CDS1, INPP4A, PIP4K2C, PIP5K1B, ITPK1, PLCG2, PIK3R3, PI4KB, DGKE, INPP5B, INPPL1, INPP5K, PRKCG, IMPA2, PLCB1, DGKQ",0.120330794367946,0,FALSE
+"H2126","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.27303,0.805,0.756,5228,1,"GUSB, HMBS, CP, COX15, BLVRB, ALAD, BLVRA, PPOX",0.121478204498793,0,FALSE
+"H2126","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.37557,1.13,0.267,1877,0.931,"PLIN1, CYP4A22, CPT1B, ANGPTL4, ACADM, ACSL1, CPT2, SLC27A2, PPARA, ACSL3, SCP2, ACOX3, RXRA",0.573488738635425,0.0310503190186574,FALSE
+"H2126","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.26912,0.799,0.788,2706,1,"SCP2, AMACR, SLC27A5",0.103473782510445,0,FALSE
+"H2126","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.40324,1.19,0.196,3895,0.87,"BLNK, CD4, JAK3, CD40, ADA, CD19, IKBKG",0.707743928643524,0.0604807473813815,FALSE
+"H2126","Input","KEGG_PRION_DISEASES",-0.36092,-1.27,0.19,15924,0.629,"SOD1, IL1A, NCAM2, IL1B, ELK1, NOTCH1, NCAM1, PRKACA, C5, EGR1, STIP1, FYN",0.721246399047171,0.201349354554731,FALSE
+"H2126","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28673,-1.03,0.322,16429,0.688,"MAD2L2, CCNA1, HSP90AA1, MAPK10, ADCY1, CDC25C, PIK3R1, RAF1, PRKACA, ANAPC13, CPEB1, PDE3B, PKMYT1, MAD2L1, BUB1, GNAI1, CCNB2, PLK1, CDK1, CCNA2, CDC25A, HSP90AB1, AKT3, ADCY7, GNAI2, CCNB1",0.492144128304169,0.162411561764489,FALSE
+"H2126","Input","KEGG_PROPANOATE_METABOLISM",0.37599,1.09,0.32,5481,0.917,"MCEE, LDHC, ACADM, ALDH6A1, ACACB, SUCLG2, ACSS2, ALDH2, ACACA, ALDH3A2, PCCB, MLYCD, LDHA, LDHAL6B",0.494850021680094,0.0376306643299789,FALSE
+"H2126","Input","KEGG_PROSTATE_CANCER",0.22319,0.655,0.932,4356,1,"CASP9, INS, CREB3L4, IKBKB, RELA, ERBB2, CREB3L2, SOS2, ATF4, IGF1R, PDGFB, PIK3R3, AKT1, FOXO1, MAPK3, CREB1, EP300, IKBKG, SOS1, MTOR, SRD5A2, MAPK1",0.0305840876460186,0,FALSE
+"H2126","Input","KEGG_PROTEASOME",-0.33383,-1.18,0.221,14960,0.688,"PSMB6, PSMB11, PSMD2, PSMC5, PSMD8, PSMD13, PSMA4, PSMB2, PSMD1, PSMD14, PSMA1, PSMB1, PSMC3, PSMA2, PSMB7, PSMD6",0.655607726314889,0.162411561764489,FALSE
+"H2126","Input","KEGG_PROTEIN_EXPORT",0.47612,1.4,0.0774,6187,0.738,"SRPRA, SRP54, SPCS2, IMMP1L, SEC61A1, OXA1L, SEC62, SPCS3, SPCS1, SRP72, HSPA5, SRPRB, SRP68, SEC61B, IMMP2L",1.11125903931711,0.131943638176958,FALSE
+"H2126","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.28306,-1.01,0.378,15771,0.631,"PCK2, ATP1A3, SLC38A3, MDH1, CA2, ATP1A1, GLS",0.422508200162775,0.199970640755866,FALSE
+"H2126","Input","KEGG_PURINE_METABOLISM",0.27774,0.822,0.729,4157,1,"ADCY5, ENTPD8, PDE4D, ADCY4, CANT1, PRUNE1, PDE8B, PDE4A, GUCY2D, PRPS1, POLR2J2, NT5C2, ENTPD2, ENTPD5, ADCY6, ENTPD6, POLR3F, POLR3GL, NME3, AK7, GMPR2, NUDT9, GDA, PRPS1L1, ADA, POLD4, PDE10A, POLR2J3, PAPSS2, PDE5A, PRPS2, ITPA, ENPP1, XDH, AMPD3, POLR2K",0.137272471682025,0,FALSE
+"H2126","Input","KEGG_PYRIMIDINE_METABOLISM",0.18309,0.529,0.995,4292,0.992,"ENTPD8, TYMP, CANT1, CMPK1, POLR2J2, NT5C2, ENTPD5, ENTPD6, POLR3F, POLR3GL, NME3, TXNRD1, POLD4, POLR2J3, ITPA, CAD, POLR2K, CTPS2, CDA",0.00217691925427455,0.00348832784582135,FALSE
+"H2126","Input","KEGG_PYRUVATE_METABOLISM",0.28879,0.851,0.702,5481,1,"LDHC, ACACB, LDHD, ACSS2, ALDH2, ACACA, PC, ALDH3A2, HAGH, DLAT, MDH2, PDHA1, ME1, LDHA, GRHPR, DLD, LDHAL6B",0.153662887870195,0,FALSE
+"H2126","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.20719,0.609,0.957,4066,1,"BDKRB2, BDKRB1, CD14, ITGB2, INS, VAV1, ARHGEF4, FGF12, FGF19, SLC9A1, ITGB6, SSH3, RDX, PIP4K2C, PIP5K1B, WASL, ITGB5, SOS2, ITGA1, MYH14, PAK4, PAK6, ARPC1A, ITGAL, FGF11, PDGFB, PIK3R3, ITGA2B, ARHGAP35, IQGAP1, ARPC1B, VAV2, FGFR3, ARHGEF1, MAPK3, ARHGEF12, ARHGEF7, ROCK1, ITGB1, FGD3, SOS1, TIAM1, RRAS",0.0190880622231565,0,FALSE
+"H2126","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.24372,0.72,0.874,5460,1,"INS, PRKAA2, ATG4C, PRKAA1, ULK3, ULK1, GABARAPL1, ULK2, BECN2",0.058488567365597,0,FALSE
+"H2126","Input","KEGG_RENAL_CELL_CARCINOMA",0.25122,0.735,0.87,4372,1,"ARNT2, GAB1, EPAS1, EGLN2, ARNT, SOS2, PAK4, PAK6, PDGFB, PIK3R3, AKT1, MAPK3, VEGFC, EP300, SOS1, VEGFA, MAPK1, VEGFD",0.0604807473813815,0,FALSE
+"H2126","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32455,0.947,0.526,2328,1,"CTSA, ACE2, NLN",0.279014255846261,0,FALSE
+"H2126","Input","KEGG_RETINOL_METABOLISM",0.4369,1.27,0.126,4313,0.713,"CYP4A22, CYP2A7, RDH10, DGAT1, CYP2A6, RDH16, CYP26B1, PNPLA4, DHRS3, ALDH1A2, DGAT2, RDH11, CYP26C1, CYP3A43",0.899629454882437,0.146910470148134,FALSE
+"H2126","Input","KEGG_RIBOFLAVIN_METABOLISM",0.55933,1.63,0.0197,5192,0.473,"RFK, ACP6, PHPT1, ACP1, FLAD1, ENPP1, ACP2",1.70553377383841,0.325138859262188,FALSE
+"H2126","Input","KEGG_RIBOSOME",-0.24649,-0.866,0.597,17221,0.792,"RPS12, RPL29, RPS26, RPL22L1, FAU, RPL24, RPL35, RPL5, RPL15, RPL35A, RPL26L1, RPL32, RPL14, RPSA, RPS20, RPL17",0.224025668870631,0.101274818410506,FALSE
+"H2126","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.22133,0.648,0.942,6603,1,"IRF3, TRAF2, NLRX1, DHX58, IKBKB, RELA, TKFC, TRADD, MAPK13, TBK1, IKBKG, MAVS, TRAF3, OTUD5, MAPK11, NFKBIB, FADD, NFKBIA, DDX3X, CASP8, IFIH1, TRIM25, MAPK12, RIPK1, CASP10, TBKBP1",0.0259490972071227,0,FALSE
+"H2126","Input","KEGG_RNA_DEGRADATION",-0.3358,-1.17,0.242,17314,0.625,"EXOSC9, EXOSC7, LSM1, CNOT10, PATL1, EXOSC3, HSPD1, DCP2, LSM6, LSM5, LSM3, ENO2, DCP1B",0.616184634019569,0.204119982655925,FALSE
+"H2126","Input","KEGG_RNA_POLYMERASE",-0.19769,-0.715,0.858,17487,0.92,"POLR1E, POLR2D, POLR2E",0.0665127121512946,0.0362121726544447,FALSE
+"H2126","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.33451,0.98,0.484,3468,1,"BUD23, CTH, AHCYL1, METTL2B, HEMK1, AHCYL2, PAPSS2",0.315154638355588,0,FALSE
+"H2126","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.21519,0.626,0.96,3187,1,"CASP9, TRAF4, TRAF2, PIAS3, XIAP, IKBKB, RELA, RXRA, PIK3R3, APAF1, ITGA2B, LAMA3, AKT1, BIRC3, LAMA5",0.0177287669604316,0,FALSE
+"H2126","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.33582,0.99,0.463,4565,1,"GOSR2, BET1, BET1L, STX19, GOSR1, STX17, VAMP7, STX16, SNAP23, VAMP8, YKT6, VTI1B, SEC22B, VAMP4, STX1A",0.334419008982047,0,FALSE
+"H2126","Input","KEGG_SPHINGOLIPID_METABOLISM",0.28133,0.823,0.739,2479,1,"SGPP1, ARSA, DEGS2, PLPP3, GALC, ASAH1, ENPP7",0.131355561605174,0,FALSE
+"H2126","Input","KEGG_SPLICEOSOME",-0.31632,-1.17,0.27,16081,0.625,"PRPF18, SNRPD2, SF3B6, RBMX, CDC5L, SRSF3, MAGOHB, HNRNPU, SF3A2, LSM2, SNRPD1, HSPA8, SRSF1, HSPA6, HNRNPC, HNRNPA1, PPIL1, SYF2, SF3B3, ALYREF, HNRNPM, SRSF10, SNRPB, HNRNPK, U2SURP, PQBP1, HNRNPA1L2, TRA2B, SMNDC1, SF3B5, HNRNPA3, ISY1, SNRPE, SNRPC, U2AF1, LSM6, BCAS2, PRPF19, LSM5, LSM3, TXNL4A",0.568636235841013,0.204119982655925,FALSE
+"H2126","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.3691,1.1,0.31,5886,0.917,"GYS1, HK2, GUSB, UGDH, GAA, PGM1, PYGL, ENPP1, MGAM, PGM2, UGP2, G6PC2, PYGB",0.508638306165727,0.0376306643299789,FALSE
+"H2126","Input","KEGG_STEROID_BIOSYNTHESIS",0.45101,1.32,0.115,5705,0.742,"MSMO1, CYP27B1, LIPA, NSDHL, DHCR7, DHCR24, SC5D, TM7SF2",0.939302159646388,0.129596094720973,FALSE
+"H2126","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38017,1.11,0.301,4720,0.92,"SRD5A3, SULT2B1, CYP1B1, CYP11B1, HSD17B8, SRD5A1, COMT, AKR1C2, SRD5A2, CYP3A43, HSD17B2",0.521433504406157,0.0362121726544447,FALSE
+"H2126","Input","KEGG_SULFUR_METABOLISM",0.56845,1.7,0.0149,4359,0.44,"SULT2B1, SULT1A3, SUOX, SULT1A4, PAPSS2, CHST11, SULT1A2, CHST12",1.82681373158773,0.356547323513813,FALSE
+"H2126","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.31191,-1.1,0.263,11837,0.614,"CTSG, FCGR2B, CD80, C9, IL10, C6, C7, CD86, FCGR2C, TNF, GRIN2A, SNRPD3, GRIN2B, ELANE, ACTN2, FCGR2A, SNRPD1, SSB, C5, C1R, SNRPB, ACTN1",0.580044251510242,0.211831628858832,FALSE
+"H2126","Input","KEGG_TASTE_TRANSDUCTION",0.43734,1.28,0.13,3465,0.789,"TAS2R3, TAS1R3, TAS2R4, ADCY4, SCNN1A, TAS2R38, ADCY6, TAS2R10, TAS2R5, TAS2R39, CACNA1A, TAS2R41",0.886056647693163,0.10292299679058,FALSE
+"H2126","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.28006,0.83,0.73,1945,1,"CSAD",0.136677139879544,0,FALSE
+"H2126","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.31235,0.919,0.592,4183,1,"DHDDS, MVD, PDSS2, PMVK",0.22767829327708,0,FALSE
+"H2126","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.22574,0.658,0.926,3917,1,"INHBB, TGFBR1, BMP6, SP1, BMP7, ID1, THBS3, BMP8B, SMURF1, LTBP1, ID3, RBL2, BMP8A, MAPK3, EP300, ROCK1, PPP2R1B, SMAD2, E2F5",0.0333890133180656,0,FALSE
+"H2126","Input","KEGG_THYROID_CANCER",-0.32728,-1.11,0.289,17604,0.622,"PAX8, NCOA4, TP53, TCF7, HRAS, NRAS",0.539102157243452,0.206209615309181,FALSE
+"H2126","Input","KEGG_TIGHT_JUNCTION",-0.22937,-0.85,0.675,15576,0.785,"CLDN11, CASK, CLDN22, JAM2, PARD3, PRKCA, MYLPF, PPP2R2A, MYL5, RAB3B, CSNK2A2, MYH9, PPP2R2B, MYH15, RRAS2, MRAS, LLGL1, MAGI2, JAM3, CDC42, TJAP1, RHOA, MYL9, GNAI1, ACTN1, ACTG1, HRAS, PARD6G, NRAS, MPDZ, CSNK2B, AKT3, CDK4, GNAI2, PPP2R2D, ACTB, EPB41L2",0.170696227168975,0.105130343254747,FALSE
+"H2126","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.26952,0.79,0.759,3895,1,"LBP, CD14, TIRAP, IRAK4, IRF3, MAP3K8, IKBKB, RELA, PIK3R3, CD40, MAPK13, AKT1, MAP2K7, TAB1, TBK1, MAPK3, TLR3, MYD88, IKBKG",0.11975822410452,0,FALSE
+"H2126","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.28315,-1.01,0.419,16065,0.631,"TPH1, WARS2, AOX1, KYNU, OGDHL, CYP1A1, ALDH1B1, ECHS1, ACAT1, ALDH9A1, AADAT",0.377785977033705,0.199970640755866,FALSE
+"H2126","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.37967,1.13,0.254,4356,0.931,"IRS2, INS, HK2, CACNA1D, IKBKB, SOCS2, PIK3R3, CACNA1A, MAPK3, SOCS4, PRKCD, MTOR, MAPK1",0.595166283380062,0.0310503190186574,FALSE
+"H2126","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.46804,1.37,0.0908,1507,0.755,"CPE, INS, ICA1, PTPRN2",1.04191415147891,0.122053048370812,FALSE
+"H2126","Input","KEGG_TYROSINE_METABOLISM",0.48019,1.39,0.0829,2664,0.727,"TH, ALDH3B2, ALDH3B1, BUD23, HGD, AOC2, TAT, GSTZ1, METTL2B, AOC3, COMT, HEMK1",1.08144546944973,0.138465589140962,FALSE
+"H2126","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17101,-0.629,0.985,15187,0.987,"PIK3CD, MAP3K14, MAPK14, MAP2K1, CD8A, MAP3K7, CARD11, CSF2, RASGRP1, PAK3, GSK3B, PPP3R1, NFKBIE, DLG1, PIK3R1, RAF1, NFATC2, CDC42, RHOA, JUN, HRAS, NRAS, BCL10, AKT3, MALT1, CDK4, FYN",0.00656376950238827,0.00568284733036327,FALSE
+"H2126","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.22621,0.655,0.938,4294,1,"RHOBTB2, PPIL2, CUL7, ANAPC2, CUL5, PIAS3, CBLC, XIAP, FBXW8, UBOX5, UBE4A, CDC16, UBE2Q1, SMURF1, SYVN1, HERC1, UBE2Q2, FBXO4, UBE2H, NHLRC1, UBE2M, ANAPC5, DET1, UBE2G2, WWP1, BIRC3, MID1, HUWE1, ITCH, ANAPC11, BTRC, DDB2, UBE2G1, BIRC2",0.0277971616209356,0,FALSE
+"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3008,0.894,0.636,2403,1,"BCAT2, VARS2",0.196542884351586,0,FALSE
+"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30329,0.887,0.624,4339,1,"MCEE, ACAD8, ACADM, ALDH6A1, BCAT2, BCKDHA, AUH, OXCT2, ACADS, HMGCL, ALDH2, ALDH3A2, ACAA1, HADHB, PCCB",0.204815410317576,0,FALSE
+"H2126","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28432,0.834,0.73,4652,1,"ADCY5, CYP4A22, ADCY4, PLA2G6, CALML6, ITPR1, ADRA1D, CACNA1D, PLA2G12A, PPP1R14A, PLA2G10, ADCY6, PRKCH, PLA2G2D, PLA2G2C, ARHGEF1, MAPK3, PRKCD, ARHGEF12, ROCK1, PLA2G4A, PRKCG, PLCB1, KCNMB3, MAPK1, CACNA1F, GNAQ, PLA2G4B, NPR2",0.136677139879544,0,FALSE
+"H2126","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.25984,0.757,0.834,3924,1,"AQP3, CREB3L4, RAB11B, NSF, CREB3L2, ADCY6, DYNC1LI2, RAB5B, CREB1, DYNC2LI1",0.0788339493622613,0,FALSE
+"H2126","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.25173,0.739,0.842,4798,1,"CASP9, PLA2G6, PLA2G12A, PLA2G10, PLCG2, PLA2G2D, PIK3R3, MAPK13, AKT1, PLA2G2C, MAPK3, PLA2G4A, MAPKAPK2, PRKCG, VEGFA, MAPK1, PLA2G4B, MAPK11, PXN",0.0746879085003505,0,FALSE
+"H2126","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.28025,0.83,0.721,4398,1,"ATP6V1B1, ATP6V0A4, ATP6AP1, KDELR3, PDIA4, ERO1A, TCIRG1, PLCG2, KDELR1, KDELR2, ATP6V0B, ATP6V0E2, PRKCG, SEC61A1, ATP6V1G1, ARF1, TJP2",0.142064735280571,0,FALSE
+"H2126","Input","KEGG_VIRAL_MYOCARDITIS",0.22878,0.673,0.916,2655,1,"CASP9, ITGB2, CD55, MYH14, ITGAL, CD40",0.0381045263321496,0,FALSE
+"H2126","Input","KEGG_WNT_SIGNALING_PATHWAY",0.2155,0.622,0.954,1426,1,"WNT3A, FZD10, CSNK1E, FRAT1, WNT4, WNT7B, WNT11, LRP5, FRAT2",0.0204516252959049,0,FALSE
+"H520","Input","KEGG_ABC_TRANSPORTERS",0.22153,0.618,0.959,3230,1,"ABCC5, ABCB7, ABCA7, ABCA3, ABCC2, ABCD4, ABCC8",0.0181813928293364,0,FALSE
+"H520","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.46206,1.28,0.134,3881,0.641,"ZBTB16, EIF4EBP1, TCF7, RUNX1, MAP2K1, MAP2K2, LEF1, TCF7L2, PIK3CA, BRAF, RAF1, MTOR, SOS1, PIK3CB, RPS6KB2, SOS2, PIK3R2, AKT2",0.872895201635192,0.193141970481183,FALSE
+"H520","Input","KEGG_ADHERENS_JUNCTION",-0.31888,-1.12,0.276,17653,0.785,"MET, PTPRB, SNAI2, PTPN1, SNAI1, RAC2, VCL, NECTIN2, PTPRM, IQGAP1, PTPRJ, CDC42, ACTB, ERBB2, RHOA, EGFR, INSR, TGFBR2, IGF1R, BAIAP2",0.559090917934782,0.105130343254747,FALSE
+"H520","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.26156,0.724,0.864,4366,1,"ADIPOQ, PRKCQ, PCK2, PTPN11, STK11, MAPK9, MTOR, CAMKK2, PRKAG1, NFKBIB, SLC2A1, ADIPOR1, AKT2, PRKAB2, ACACB",0.0634862575211067,0,FALSE
+"H520","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.41546,1.17,0.228,3710,0.773,"GPT2, GLUD2, GOT2, ASNS, CAD, GAD1, GLUL, PPAT, ASS1",0.642065152999546,0.111820506081675,FALSE
+"H520","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.26264,0.732,0.875,2852,1,"IGF1, KCNJ1, PIK3CA, PDPK1, SCNN1A, PIK3CB",0.0579919469776868,0,FALSE
+"H520","Input","KEGG_ALLOGRAFT_REJECTION",-0.31593,-1.1,0.287,17766,0.757,"CD40, IL12A, FAS",0.542118103266008,0.120904120499927,FALSE
+"H520","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.30686,0.863,0.68,3580,1,"PLA2G12A, FADS2, PLA2G3",0.167491087293764,0,FALSE
+"H520","Input","KEGG_ALZHEIMERS_DISEASE",0.3064,0.856,0.697,5666,0.999,"NDUFS5, ITPR1, NDUFS7, ADAM10, CASP7, ATP2A1, NDUFB10, COX4I1, UQCR11, SDHB, NDUFA2, NDUFA10, ATP5F1D, NAE1, LPL, NDUFA9, COX7C, ERN1, COX7A2L, NDUFA7, PPP3R1, ATP5F1C, UQCRQ, CALML5, NDUFA4L2, COX5A, NDUFAB1, GSK3B, NDUFC2, ATP5MC3, NDUFB6, APH1A, PSEN2, MME, CDK5R1, PLCB1, NDUFB7, UQCRC2, NDUFS6, NDUFA4, ATP2A2, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, CALML6, RYR3, NDUFB1, ADAM17, NDUFC1, PSEN1, UQCRB, MAPK1, ATP5F1A, NDUFV1, NDUFB5, CALML3",0.156767221901991,0.000434511774017692,FALSE
+"H520","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.50499,1.41,0.0633,7188,0.564,"WARS2, RARS2, EARS2, SEPSECS, HARS2, FARSB, MARS2, MTFMT, CARS2, LARS2, IARS2, PARS2, FARSA, TARS2",1.19859628998265,0.248720896016658,FALSE
+"H520","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.45499,-1.61,0,16174,0.72,"GCK, NPL, RENBP, FPGT, UGDH, UAP1, GMPPA, UXS1, CYB5R1, HEXB, CYB5R3, NAGK, GALK1, CMAS, GALE, NANP, PGM1",Inf,0.142667503568732,FALSE
+"H520","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28112,0.783,0.801,1987,1,"SLC1A2, SOD1, NEFL, DERL1, MAP2K6",0.0963674839157623,0,FALSE
+"H520","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.29611,0.825,0.739,1328,1,"IFNA5, NFYC, RFXAP, NFYB, CANX, CREB1",0.131355561605174,0,FALSE
+"H520","Input","KEGG_APOPTOSIS",-0.2831,-0.978,0.468,14862,0.725,"BCL2, IRAK4, PPP3R2, TNF, CASP8, PIK3R1, PRKAR2B, PRKAR2A, NFKBIA, TNFRSF10C, IRAK3, AKT3, IKBKB, IL1A, TNFRSF1A, IL1B, NGF, BAX, ENDOD1, BID, BIRC3, TP53, PIK3CD, CASP10, TRADD, TNFRSF10D, CAPN2, FAS, IL1RAP, CAPN1, MAP3K14",0.329754146925876,0.139661993429006,FALSE
+"H520","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.17423,-0.62,0.979,13977,0.968,"ALOX15, CYP2C8, PLA2G1B, CYP4A22, CYP4F3, GGT6, GGT7, PTGS1, PTGIS, GGT5, CBR3, PTGDS, ALOX5, PTGES2, PTGS2, CYP2E1, GPX1, PTGES, EPHX2",0.00921730819686218,0.0141246426916063,FALSE
+"H520","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.36736,1.04,0.389,3744,0.843,"SMS, GLUD2, ARG2, GOT2, MAOB, PYCR1, CKB, ALDH2, ALDH9A1, PYCR2, SAT1, GLUL, ASS1, ALDH3A2",0.410050398674292,0.0741724253752577,FALSE
+"H520","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.23383,-0.792,0.759,14536,0.899,"ITGA7, SGCD, ITGA10, TCF7L1, ACTN1, ITGA1, SGCA, ACTN2, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, ITGB6, GJA1, ITGB3, CACNA2D1, ITGA5, LMNA, DAG1, ITGB1, ACTB, ITGA3, CACNB3",0.11975822410452,0.0462403082667712,FALSE
+"H520","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.55198,1.54,0.0306,4712,0.683,"UGT2A1, MIOX, ALDH2, ALDH9A1, ALDH3A2, ALDH7A1",1.51427857351842,0.165579296318467,FALSE
+"H520","Input","KEGG_ASTHMA",0.64109,1.79,0.00557,55,0.995,"EPX",2.25414480482627,0.00217691925427455,FALSE
+"H520","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.62081,1.73,0.00768,438,0.489,"CTLA4, IFNA5, PRF1",2.11463877996849,0.31069114087638,FALSE
+"H520","Input","KEGG_AXON_GUIDANCE",-0.26297,-0.872,0.494,17072,0.8,"CDK5, EPHB6, SEMA3E, EFNB3, NFATC2, SLIT2, CFL1, NGEF, MET, SEMA4A, EFNB2, EFNB1, EPHA2, NRP1, NFATC1, EFNA3, SEMA7A, RAC2, ABLIM3, ITGB1, NTN4, CDC42, L1CAM, SEMA3A, EFNA1, EPHB2, EFNA5, RHOA, SEMA4B, PLXNB2, SRGAP1, SEMA3C",0.306273051076353,0.0969100130080564,FALSE
+"H520","Input","KEGG_BASAL_CELL_CARCINOMA",0.39497,1.09,0.304,4056,0.91,"DVL3, AXIN2, TCF7, SHH, APC, FZD1, LEF1, WNT11, TCF7L2, FZD3, PTCH2, AXIN1, CTNNB1, FZD10, GSK3B, BMP4, WNT8B",0.517126416391246,0.0409586076789064,FALSE
+"H520","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.43897,1.23,0.17,4856,0.712,"GTF2F1, TAF1, GTF2A2, TBP, TAF6L, GTF2A1, GTF2H3, TAF7, TAF2, TAF5, TAF1L, TAF9B, TAF11, GTF2IRD1",0.769551078621726,0.147520006363144,FALSE
+"H520","Input","KEGG_BASE_EXCISION_REPAIR",0.33446,0.938,0.547,6120,0.942,"MUTYH, MBD4, POLD3, TDG, LIG3, NEIL1, POLL, NTHL1, POLE, FEN1, POLE4, XRCC1, POLE3, POLD2, OGG1, NEIL3",0.262012673666569,0.0259490972071227,FALSE
+"H520","Input","KEGG_BETA_ALANINE_METABOLISM",0.5122,1.43,0.0671,5769,0.666,"SMS, ALDH2, ALDH9A1, CNDP1, HADHA, GAD1, HIBCH, ALDH3A2, ALDH7A1, AOC3, EHHADH, MLYCD, AOC2",1.17327747983101,0.176525770829699,FALSE
+"H520","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.26181,0.735,0.854,3576,1,"HACD2, PECR, HADHA, FADS2, HSD17B12, TECR",0.068542129310995,0,FALSE
+"H520","Input","KEGG_BLADDER_CANCER",-0.2505,-0.872,0.607,17931,0.8,"CXCL8, PGF, TYMP, VEGFC, DAPK1, CDKN1A, TP53, ERBB2, EGFR",0.216811308924742,0.0969100130080564,FALSE
+"H520","Input","KEGG_BUTANOATE_METABOLISM",0.38102,1.06,0.343,5901,0.879,"OXCT2, ALDH2, PDHA1, ALDH9A1, HADH, HADHA, GAD1, L2HGDH, ALDH3A2, AACS, ALDH7A1, EHHADH, BDH1, ACAT1",0.464705879957229,0.0560111249262281,FALSE
+"H520","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.24486,0.689,0.904,4278,1,"SYK, MALT1, NFATC3, MAP2K1, MAP2K2, PIK3CA, RAF1, SOS1, PPP3R1, PIK3CB, NFKBIB, GSK3B, SOS2, PIK3R2, AKT2, RAC3, PTPN6",0.0438315695246367,0,FALSE
+"H520","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.28608,0.782,0.776,3460,1,"CACNA1E, CHRM3, HTR2C, SLC8A1, PHKB, ADCY7, ITPR1, SLC25A4, MYLK2, CHRNA7, GNAL, ATP2A1, VDAC2, GNA11, PHKA2, LTB4R2, ADRB1, VDAC1, PHKA1, ERBB4, PPP3R1, SLC25A5, PRKX, CACNA1B, ADCY1, PRKACB, PPID, CALML5",0.110138278741812,0,FALSE
+"H520","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.16116,0.456,0.999,5367,0.999,"SLC8A1, CACNA2D3, COX4I1, UQCR11, COX7C, COX7A2L, UQCRQ, COX5A, UQCRC2, ATP2A2, UQCRHL, CYC1, ATP1B3, ATP1B1, UQCRB",0.000434511774017692,0.000434511774017692,FALSE
+"H520","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.29701,0.831,0.739,1475,1,"CTLA4, SELE, NRXN3, MADCAM1, CNTN1, NRCAM, NLGN3, CADM1",0.131355561605174,0,FALSE
+"H520","Input","KEGG_CELL_CYCLE",0.44489,1.24,0.169,5198,0.702,"RAD21, GADD45G, CDC14A, ORC6, CDC23, FZR1, ORC3, STAG2, ORC2, ESPL1, TGFB2, CDC20, CCNB2, CDK1, CHEK1, MCM2, PLK1, CREBBP, BUB1B, CDKN2D, SMAD4, CDC25C, ATM, RBL1, E2F2, MAD2L1, PKMYT1, TTK, ANAPC7, STAG1, BUB3, SKP2, E2F4, ANAPC1, ORC5, ZBTB17, ORC4, CDKN2A, GSK3B, RBL2, E2F1, CDC27, BUB1, MAD2L2, MCM6, RB1, CCNH, SKP1, ATR, CDK6, SMAD2, ANAPC11, CCNA2, EP300, HDAC2, MCM3, CDC14B",0.772113295386326,0.153662887870195,FALSE
+"H520","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.20211,0.564,0.975,4667,1,"CXCL14, CCL27, XCL1, ADCY7, CXCR4, GRK6, PAK1, ELMO1, MAP2K1, GNB1, XCL2, PIK3CA, BRAF, RAF1, SOS1, TIAM1, GNG2, PIK3CB, PRKX, WAS, NFKBIB, ADCY1, PRKACB, GSK3B, GSK3A, SOS2, PIK3R2, AKT2, CXCR2, GRK2, GNG7, PTK2, PLCB1, PRKCZ, GNAI1, CRKL, GNB3",0.0109953843014632,0,FALSE
+"H520","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.31649,0.893,0.667,5613,0.973,"RUNX1, MAP2K1, MAP2K2, CTBP1, PIK3CA, PTPN11, TGFB2, BRAF, RAF1, CBL, SOS1, SMAD4, E2F2, PIK3CB, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, TGFBR1, RB1, CRKL, CDK6, BCL2L1, HDAC2, MAPK1, CTBP2, CRK, MYC, E2F3",0.175874166083451,0.0118871597316481,FALSE
+"H520","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.22889,-0.853,0.705,17633,0.804,"PER1, BHLHE41",0.151810883008601,0.0947439512515487,FALSE
+"H520","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2508,0.697,0.9,5651,1,"PCK2, PDHA1, SDHB, IDH1, FH, DLAT, DLST, SUCLA2, SUCLG1",0.0457574905606751,0,FALSE
+"H520","Input","KEGG_COLORECTAL_CANCER",0.36715,1.03,0.424,4149,0.823,"AXIN2, TCF7, APC, MAP2K1, LEF1, TCF7L2, PIK3CA, TGFB2, BRAF, RAF1, MAPK9, SMAD4, AXIN1, PIK3CB, CTNNB1, BIRC5, GSK3B, APPL1, PIK3R2, AKT2, TGFBR1, RAC3",0.372634143407267,0.0846001647877302,FALSE
+"H520","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.3245,-1.11,0.272,15340,0.77,"VWF, A2M, C4A, C3AR1, CD55, C1S, C4BPB, SERPING1, CFB, PROS1, THBD, BDKRB1, CFI, SERPINA1, BDKRB2, CFH, F3, C3, PLAT, SERPINE1, F2R, PLAU, TFPI, CD59, PLAUR",0.565431095965801,0.113509274827518,FALSE
+"H520","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.4262,1.19,0.218,5408,0.744,"SMS, GOT2, CBS, MAT2A, MAT2B, APIP, DNMT3B, ADI1, DNMT3A, MTAP, AHCY, DNMT1",0.661543506395395,0.128427064454121,FALSE
+"H520","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.24216,-0.853,0.646,16314,0.804,"PDGFC, IL18R1, TNFRSF6B, IL1A, CSF2, CCL5, VEGFB, CXCR6, PDGFRB, TNFRSF11A, PDGFA, LEPR, IFNAR2, IL7, TNFSF15, TNFRSF1A, IL1B, CCL20, CSF2RA, CCL26, CD70, CXCL16, CX3CL1, BMP2, CCR10, IL7R, CCL28, IL6, TNFRSF25, INHBA, IL17RA, CXCL3, MET, IFNGR1, CXCL1, CD40, ACVR2A, TGFB3, CXCL2, CXCL8, CTF1, IL12A, TNFSF12, VEGFC, TNFSF13, TNFSF9, ACVR1, IL18, TNFRSF14, IL6R, TNFRSF10D, PLEKHO2, TGFB1, CSF1, OSMR, LIF, FAS, IL6ST, CLCF1, EGFR, IL1RAP, TGFBR2, IL4R, TNFRSF12A",0.189767482004916,0.0947439512515487,FALSE
+"H520","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.27384,-0.971,0.452,15432,0.718,"CXCL10, AIM2, POLR3H, NFKBIA, RIPK3, IKBKB, DDX58, CCL5, IL1B, IL6, CASP1, POLR1C, IRF3, TBK1, IL18, POLR3F, IKBKE",0.344861565188618,0.1438755557577,FALSE
+"H520","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.29087,-1.05,0.348,15170,0.683,"ITGA1, TNF, SGCA, TNNC1, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, ADCY4, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, ITGB6, GNAS, ITGB3, TNNI3, CACNA2D1, TGFB3, TPM1, ITGA5, LMNA, ADCY9, DAG1, ITGB1, TGFB1, TPM2, ACTB, ITGA3, CACNB3",0.458420756053419,0.165579296318467,FALSE
+"H520","Input","KEGG_DNA_REPLICATION",0.48576,1.33,0.0969,6012,0.603,"RFC4, RNASEH1, DNA2, POLA1, POLD3, MCM2, RNASEH2C, MCM6, RNASEH2B, RFC1, POLE, RFC5, RPA4, FEN1, POLE4, PRIM2, MCM3, MCM7, POLE3, POLD2, RNASEH2A, RPA2, RFC3, POLA2",1.01367622294923,0.219682687859849,FALSE
+"H520","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.40979,-1.45,0.0833,18696,0.797,"ETV6, EGFR, ETS2, ETS1, SPIRE1",1.07935499859321,0.0985416786038876,FALSE
+"H520","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.21311,-0.749,0.855,16067,0.878,"GSTM1, GSTM3, GSTT2, FMO4, CYP2E1, AOX1, GSTM4, MAOA, GSTO1, ALDH3B1, GSTK1, MGST3",0.0680338852718274,0.0565054840938974,FALSE
+"H520","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.26675,0.732,0.869,1088,1,"UCK2, UGT2A1, CES1, GMPS",0.0609802235513335,0,FALSE
+"H520","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43593,-1.5,0.0659,15170,0.819,"ITGA1, GP6, RELN, VWF, LAMC3, COL11A1, ITGA2, COL5A1, COL5A3, ITGB5, THBS2, ITGA2B, CD36, COL6A3, ITGA11, COL6A2, SDC3, ITGA4, COL3A1, LAMA1, COL1A2, LAMC2, SDC2, COL5A2, ITGAV, ITGB8, COL4A2, ITGB6, ITGB3, LAMA4, LAMB2, COL6A1, COL1A1, AGRN, LAMA3, ITGA5, TNC, COL4A1, DAG1, LAMA5, ITGB1, LAMB3, SDC4, ITGA3, HSPG2, LAMB1",1.18111458540599,0.0867160982395816,FALSE
+"H520","Input","KEGG_ENDOCYTOSIS",-0.20867,-0.761,0.832,17598,0.896,"ADRB2, ARFGAP1, VPS37D, LDLRAP1, MET, FGFR2, STAM, PARD6B, ASAP3, CHMP4B, ARAP2, ACAP1, HSPA1B, ARAP3, DAB2, F2R, SMURF1, CDC42, PLD1, EHD1, RAB31, CLTCL1, EHD2, EGFR, ARAP1, ARRB1, IQSEC2, IGF1R, RAB11FIP5",0.0798766737092761,0.0476919903378748,FALSE
+"H520","Input","KEGG_ENDOMETRIAL_CANCER",0.48157,1.34,0.0976,3881,0.625,"CTNNA2, AXIN2, TCF7, APC, MAP2K1, MAP2K2, LEF1, TCF7L2, PIK3CA, PDPK1, BRAF, RAF1, CTNNA1, SOS1, AXIN1, PIK3CB, CTNNB1, GSK3B, SOS2, PIK3R2, AKT2",1.01055018233331,0.204119982655925,FALSE
+"H520","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.24316,0.681,0.915,3902,1,"PTPRZ1, ATP6V0B, PAK1, ATP6V0A2, ATP6V1E2, ADAM10, PTPN11, MAPK9, GIT1, ATP6V1G2, ATP6V0C, ATP6V1H, F11R, CXCR2",0.0385789059335517,0,FALSE
+"H520","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.30689,0.859,0.684,4593,1,"EIF4EBP1, PAK2, PAK1, MAP2K1, MAP2K7, MAP2K2, NRG3, PIK3CA, BRAF, RAF1, MAPK9, MTOR, CBL, SOS1, ERBB4, PIK3CB, RPS6KB2, NCK1, GSK3B, SOS2, PIK3R2, AKT2, PTK2, CAMK2G, MAP2K4, TGFA, CRKL",0.164943898279884,0,FALSE
+"H520","Input","KEGG_ETHER_LIPID_METABOLISM",0.31444,0.874,0.651,3580,0.999,"PLA2G7, CHPT1, PLA2G12A, PAFAH1B2, PAFAH2, PLA2G3",0.186419011431808,0.000434511774017692,FALSE
+"H520","Input","KEGG_FATTY_ACID_METABOLISM",0.37333,1.04,0.395,6710,0.843,"ECI1, ACAA2, ALDH2, ALDH9A1, HADH, HADHA, ADH5, ALDH3A2, ALDH7A1, CPT1B, ADH6, ACADSB, EHHADH, CPT1A, ACAT1, ECI2, CPT2, GCDH, ACSL5, ECHS1, ADH1C",0.40340290437354,0.0741724253752577,FALSE
+"H520","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.31452,0.896,0.617,4149,0.977,"SYK, MAP2K1, MAP2K7, MAP2K2, PIK3CA, PDPK1, MAP2K6, RAF1, MAPK9, FYN, SOS1, PLA2G12A, PIK3CB, PLA2G3, SOS2, PIK3R2, AKT2, RAC3",0.209714835966758,0.0101054362812269,FALSE
+"H520","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.21642,-0.754,0.813,17280,0.888,"PLCG2, ARPC5, CFL1, VAV3, PLPP1, PRKCA, ARPC1B, VAV2, ASAP3, PLPP3, ARPC2, GSN, RAC2, PIK3CD, CDC42, PLD1, SPHK1, PRKCD, VASP",0.0899094544059319,0.051587034221399,FALSE
+"H520","Input","KEGG_FOCAL_ADHESION",-0.34036,-1.17,0.233,15230,0.692,"PIK3R1, ACTN2, RELN, VWF, LAMC3, FLT4, PDGFRA, COL11A1, ITGA2, COL5A1, COL5A3, MYLK, ITGB5, THBS2, ITGA2B, COL6A3, ITGA11, CCND2, PRKCG, AKT3, COL6A2, PDGFC, ACTG1, VEGFB, ITGA4, COL3A1, PDGFRB, PDGFA, LAMA1, BCAR1, COL1A2, LAMC2, RAP1B, COL5A2, ITGAV, ITGB8, COL4A2, ITGB6, ITGB3, LAMA4, CCND3, LAMB2, VAV3, MET, COL6A1, PRKCA, DOCK1, COL1A1, FLNC, RAP1A, PGF, VAV2, LAMA3, VEGFC, SHC1, BIRC3, ITGA5, MYL12A, TNC, ILK, COL4A1, MYL9, RAC2, VCL, LAMA5, FLNA, PIK3CD, ITGB1, MYL12B, PARVA, CDC42, LAMB3, CAPN2, ACTB, ERBB2, CAV2, RHOA, EGFR, CAV1, ITGA3, PXN, FLNB, IGF1R, LAMB1, VASP, ZYX",0.632644078973981,0.159893905543242,FALSE
+"H520","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.27945,-1.02,0.404,15141,0.727,"ALPG, ALPL, ALPP, QDPR, SPR, FPGS",0.393618634889395,0.138465589140962,FALSE
+"H520","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.22115,-0.776,0.737,16567,0.91,"FPGT, PFKFB4, MTMR6, PFKL, PHPT1, GMPPA, PFKFB2, PFKP",0.132532512140949,0.0409586076789064,FALSE
+"H520","Input","KEGG_GALACTOSE_METABOLISM",-0.38693,-1.39,0.121,17740,0.727,"GLB1, B4GALT1, GALK1, GALE, PFKP, PGM1",0.91721462968355,0.138465589140962,FALSE
+"H520","Input","KEGG_GAP_JUNCTION",0.32333,0.896,0.625,3267,0.977,"HTR2C, TUBB2B, MAP2K5, ADCY7, ITPR1, MAP2K1, TUBB2A, MAP2K2, MAP3K2, GNA11, CDK1, RAF1, ADRB1, PRKG2, SOS1, PRKX, ADCY1, PRKACB",0.204119982655925,0.0101054362812269,FALSE
+"H520","Input","KEGG_GLIOMA",0.31251,0.877,0.642,6125,1,"IGF1, MAP2K1, MAP2K2, PIK3CA, BRAF, RAF1, MTOR, SOS1, E2F2, PIK3CB, CALML5, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, RB1, CAMK2G, TGFA, CDK6, CALML6, EGF, MAPK1, E2F3, CALML3, CAMK2A, CALM3, PIK3R3",0.192464971931147,0,FALSE
+"H520","Input","KEGG_GLUTATHIONE_METABOLISM",0.24475,0.681,0.921,2025,1,"SMS, GPX2, GSTA4, GCLC, TXNDC12, IDH1",0.0357403698031511,0,FALSE
+"H520","Input","KEGG_GLYCEROLIPID_METABOLISM",0.40483,1.13,0.271,2416,0.838,"AKR1A1, LIPC, LCLAT1, DGKQ, DGKG, ALDH2, AGPAT4, GK, ALDH9A1, LPL",0.567030709125594,0.0767559813697235,FALSE
+"H520","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.23019,-0.811,0.689,17148,0.878,"DGKH, LCAT, ACHE, AGPAT3, PISD, GPD2, PLPP1, LYPLA2, PCYT2, PLPP3, MBOAT7, AGPAT2, PLD1, DGKA, GPD1L",0.161780778092374,0.0565054840938974,FALSE
+"H520","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.46351,1.29,0.12,2770,0.631,"PIPOX, PSPH, PHGDH, SHMT2, MAOB, CBS, CHDH, PSAT1",0.920818753952375,0.199970640755866,FALSE
+"H520","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.22013,0.609,0.953,4876,1,"AKR1A1, PCK2, ALDH3A1, ALDH2, PDHA1, ALDH9A1, HK2, ADH5, ALDH3A2, DLAT, ENO3, ALDOB, ALDH7A1, ADH6",0.0209070993616736,0,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.23729,-0.872,0.628,16826,0.8,"XYLT1, CHST11, UST, CHST3, CHPF2",0.202040356262804,0.0969100130080564,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.26186,0.73,0.873,3513,1,"NDST2, B3GAT3, HS6ST1, GLCE, HS2ST1",0.0589857562944303,0,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.34902,-1.23,0.184,17016,0.698,"B3GNT7, ST3GAL1, B4GAT1, B3GNT2, FUT8, B4GALT1",0.735182176990464,0.156144577376839,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.28559,-1,0.333,12993,0.722,"NAGLU, HEXA, GUSB, HYAL4, SGSH, HYAL2, IDS, HGSNAT, HPSE, GLB1, HEXB, GNS, GALNS",0.47755576649368,0.141462802430361,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51121,-1.79,0.0198,16108,1,"ST3GAL5, ST8SIA1, ST3GAL1, GLB1, HEXB, ST6GALNAC4, ST6GALNAC6",1.70333480973847,0,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.30192,-1.05,0.33,16360,0.683,"ST8SIA1, B3GALT5, GBGT1, ST3GAL1, NAGA, HEXB",0.481486060122112,0.165579296318467,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.50207,1.42,0.0773,2431,0.65,"B3GALT2, FUT1, B4GALT2, ST3GAL3, FUT7, FUT4, FUT9",1.11182050608168,0.187086643357144,FALSE
+"H520","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50654,1.41,0.072,5032,0.564,"PIGM, PIGX, PIGG, PIGQ, PIGH, PIGS, PIGA, PIGP, PIGN, PIGO, PGAP1, PIGV, PIGW",1.14266750356873,0.248720896016658,FALSE
+"H520","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.61907,1.72,0.00777,4790,0.388,"HAO2, MTHFD2, PGP, MTHFD1L, AFMID, MTHFD2L, HYI, GRHPR",2.10957898119909,0.411168274405793,FALSE
+"H520","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.26844,0.749,0.818,4479,1,"ADCY7, ITPR1, MAP2K1, ATF4, MAP2K7, MAP2K2, MAP3K4, MAP3K2, GNA11, MAP2K6, RAF1, MAPK9, SOS1, PLA2G12A, PRKX, ADCY1, PRKACB, CALML5, PLA2G3, SOS2, PLCB1, CAMK2G, MAP2K4",0.087246696328677,0,FALSE
+"H520","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.26891,0.74,0.863,438,1,"PRF1",0.0639892042847904,0,FALSE
+"H520","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.34723,0.965,0.521,5660,0.909,"BMP8A, SHH, CSNK1G3, BMP8B, WNT11, CSNK1G2, PTCH2, BMP7, CSNK1G1, PRKX, PRKACB, GSK3B, BMP4, WNT8B, FBXW11, RAB23, PRKACA, WNT5A, PTCH1, STK36, CSNK1E",0.283162276700476,0.0414361167780325,FALSE
+"H520","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.29731,-1.07,0.337,15170,0.762,"ITGA1, TNF, CD1D, CSF1R, ITGA2, ITGAM, FCGR1A, CD55, ITGA2B, CD22, CD36, IL1A, CSF2, ANPEP, ITGA4, IL7, CD9, IL1B, CSF2RA, CD37, IL7R, IL6, ITGB3, ITGA5, IL6R, CD59, CSF1, ITGA3, IL4R",0.472370099128661,0.1180450286604,FALSE
+"H520","Input","KEGG_HISTIDINE_METABOLISM",0.43296,1.21,0.188,2218,0.738,"LCMT1, MAOB, ALDH3A1, ALDH2, ALDH9A1, LCMT2, CNDP1",0.72584215073632,0.131943638176958,FALSE
+"H520","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.50465,1.4,0.0763,5713,0.533,"POLD3, MUS81, RAD51C, RAD54B, RAD51B, RAD51, EME1, RAD50, BLM, XRCC2, RAD54L, RAD52, MRE11, RPA4, XRCC3, BRCA2, POLD2, RPA2",1.11747546204512,0.273272790973428,FALSE
+"H520","Input","KEGG_HUNTINGTONS_DISEASE",0.3802,1.06,0.361,5916,0.879,"UCP1, NDUFS5, SOD1, ITPR1, SLC25A4, POLR2D, AP2B1, NDUFS7, POLR2G, CREB1, NDUFB10, POLR2H, COX4I1, UQCR11, NRF1, SDHB, NDUFA2, SP1, TBP, VDAC2, TFAM, NDUFA10, VDAC1, POLR2C, CREBBP, ATP5F1D, DCTN4, NDUFA9, POLR2E, COX7C, COX7A2L, NDUFA7, SIN3A, SLC25A5, ATP5F1C, UQCRQ, PPID, AP2M1, NDUFA4L2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, POLR2J, PLCB1, NDUFB7, CREB3L4, UQCRC2, NDUFS6, POLR2K, NDUFA4, NDUFS3, REST, NDUFA1, UQCRHL, NDUFB9, CYC1, EP300, HDAC2, NDUFB1, NDUFC1, UQCRB, ATP5F1A, DNAH1, NDUFV1, NDUFB5, AP2A2, CREB3, DCTN1, POLR2I, HAP1, HIP1, TBPL1",0.442492798094342,0.0560111249262281,FALSE
+"H520","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34828,-1.26,0.172,14536,0.68,"ITGA7, SGCD, ITGA10, TNNT2, ACE, ITGA1, TNF, SGCA, TNNC1, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, IL6, ITGB6, ITGB3, TNNI3, CACNA2D1, TGFB3, TPM1, ITGA5, LMNA, DAG1, ITGB1, TGFB1, TPM2, ACTB, ITGA3, CACNB3, PRKAG2",0.764471553092451,0.167491087293764,FALSE
+"H520","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.29103,0.815,0.748,5884,1,"PIP4K2B, MIOX, PIK3CA, OCRL, INPPL1, PIK3CB, PIKFYVE, PIK3C3, CDIPT, INPP5J, PLCD4, PIK3C2A, ITPKB, PLCB1, ALDH6A1, IMPA1, PIK3C2B, PI4KB, PIP5K1A, INPP5B, PIP5K1C, INPP5E, IPMK, INPP4A",0.126098402135539,0,FALSE
+"H520","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.36694,1.03,0.41,4093,0.823,"EIF4EBP1, PHKB, PPP1R3B, MKNK2, MAP2K1, MAP2K2, SOCS4, SORBS1, PCK2, TSC2, PYGM, PIK3CA, PPP1CC, PDPK1, FLOT2, ACACA, BRAF, PHKA2, EIF4E, RAF1, MAPK9, MTOR, PHKA1, CBL, SOS1, EIF4E2, PIK3CB, PRKX, PRKAG1, HK2, PRKACB, RPS6KB2, PDE3B, CALML5, RPS6, SOCS1, PPP1CB, GSK3B, SOS2, PIK3R2, AKT2, PRKAB2, PHKG2",0.387216143280265,0.0846001647877302,FALSE
+"H520","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.33611,0.929,0.576,597,0.944,"CCL27, MADCAM1, CXCR4",0.239577516576788,0.025028005701931,FALSE
+"H520","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.20307,-0.725,0.853,16023,0.878,"IL13RA2, CCND2, AKT3, IL15, STAM2, CSF2, JAK3, CBLC, LEPR, IFNAR2, IL7, CSF2RA, SOCS2, STAT4, IL7R, IL6, CCND3, IFNGR1, STAT5A, STAM, CTF1, IL12A, PIAS3, JAK1, SPRY1, STAT5B, CISH, PIK3CD, IL6R, OSMR, LIF, IL6ST, CLCF1, SOCS3, IL4R, STAT6",0.069050968832477,0.0565054840938974,FALSE
+"H520","Input","KEGG_LEISHMANIA_INFECTION",-0.36403,-1.36,0.0706,15651,0.715,"ITGAM, STAT1, NFKBIA, FCGR1A, FOS, FCGR2A, IL1A, ITGA4, TLR4, NCF2, IL1B, PTGS2, ITGB2, IFNGR1, MAPK11, TGFB3, C3, IL12A, JAK1, ITGB1, TGFB1",1.1511952989482,0.145693958198919,FALSE
+"H520","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.35323,-1.3,0.117,14879,0.708,"CLDN4, CLDN14, ACTN1, CDH5, VCAM1, CLDN22, PIK3R1, ACTN2, MMP9, CYBB, JAM2, CLDN16, CXCL12, ITGAM, EZR, PRKCG, ESAM, ACTG1, ITGA4, BCAR1, NCF2, THY1, RAPGEF3, RAP1B, CLDN9, ITGB2, PLCG2, RASSF5, SIPA1, VAV3, PRKCA, MAPK11, PTK2B, RAP1A, VAV2, MYL12A, MYL9, RAC2, VCL, CLDN1, ICAM1, PIK3CD, ITGB1, MYL12B, CDC42, ACTB, RHOA, PXN, VASP, CD99",0.931814138253838,0.149966742310231,FALSE
+"H520","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.63758,1.75,0.011,5612,0.639,"ALDH2, ALDH9A1, HADHA, ALDH3A2, ALDH7A1, EHHADH, YOD1, NAA80",1.95860731484178,0.1944991418416,FALSE
+"H520","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.16716,0.476,0.998,14427,1,"PLA2G12A, PLA2G3, CYP3A4, PLA2G6, CYP3A7, PLA2G4B, PLA2G4E, CYP2J2, PLA2G10, PLA2G4A, CYP2C9, PLA2G2E, PLA2G2D, PLA2G2A, CYP2C18, PLA2G12B, CYP1A2, CYP3A43, PLA2G5, PLA2G2C, PLA2G2F, CYP3A5, CYP2C19, ALOX15, CYP2C8, PLA2G1B, AKR1B10",0.000869458712628891,0,FALSE
+"H520","Input","KEGG_LONG_TERM_DEPRESSION",0.38407,1.07,0.359,2535,0.91,"IGF1, ITPR1, PPP2CA, MAP2K1, MAP2K2, BRAF, GNA11, RAF1, PRKG2, PPP2R1B, PLA2G12A",0.444905551421681,0.0409586076789064,FALSE
+"H520","Input","KEGG_LONG_TERM_POTENTIATION",0.34937,0.991,0.48,6008,0.892,"ITPR1, MAP2K1, ATF4, MAP2K2, RPS6KA6, PPP1CC, BRAF, RAF1, CREBBP, PPP3R1, RPS6KA2, PRKX, ADCY1, PRKACB, CALML5, PPP1CB, PLCB1, CAMK2G, PRKACA, CALML6, EP300, MAPK1, CALML3, CAMK2A, CALM3",0.318758762624413,0.0496351456238769,FALSE
+"H520","Input","KEGG_LYSINE_DEGRADATION",0.54166,1.52,0.0445,6899,0.593,"PIPOX, NSD3, KMT5A, NSD2, DOT1L, NSD1, ALDH2, SETD1A, ALDH9A1, HADH, HADHA, SETDB1, SETD1B, ALDH3A2, SUV39H2, ALDH7A1, DLST, EHHADH, KMT5C, ASH1L, ACAT1, SETDB2, AASDH, GCDH, KMT5B, PLOD3, EHMT2, ECHS1, EHMT1, SUV39H1",1.35163998901907,0.226945306635737,FALSE
+"H520","Input","KEGG_LYSOSOME",-0.3038,-1.05,0.354,16611,0.683,"NAGPA, AP3B1, PLA2G15, LAMP1, SUMF1, ACP5, SLC11A1, M6PR, AP1S3, LAPTM4A, CLN5, GM2A, CTSV, NAGA, SMPD1, CTSL, LGMN, GLB1, HEXB, GNS, CTSS, CTSH, TPP1, NEU1, GALNS, FUCA1, NPC2, AP1S1, ABCA2, CTSB, CTSD, CD68, CD63, CLTCL1, CTSA, LIPA, TCIRG1",0.450996737974212,0.165579296318467,FALSE
+"H520","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.30889,0.85,0.701,3881,1,"CACNA1E, FGF3, FGF19, FGF4, FGF21, CACNA2D3, MAP2K5, FGF20, TAOK1, GADD45G, PAK2, FGF9, PAK1, MKNK2, MAP2K1, FGFR1, NLK, ATF4, MAP2K7, MAP2K2, MAP3K13, RPS6KA6, ATF2, TGFB2, BRAF, MAP3K4, MAP3K2, DUSP16, MAPKAPK5, MAP2K6, RAF1, MAPK8IP3, MAPK9, IL1R2, ECSIT, SOS1, MAP3K7, FGFR3, PLA2G12A, DUSP14, DUSP6, PPP3R1, MAP4K3, NF1, RPS6KA2, PRKX, CACNA1B, PRKACB, FGF22, FGF13, TAOK2, PLA2G3, MAP4K1, HSPA1L, MAP4K2, SOS2, AKT2",0.154281982033341,0,FALSE
+"H520","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.38264,1.07,0.35,445,0.91,"FOXA2, ONECUT1",0.455931955649724,0.0409586076789064,FALSE
+"H520","Input","KEGG_MELANOGENESIS",0.36435,1.02,0.422,6351,0.828,"KITLG, DVL3, TCF7, ADCY7, FZD1, MAP2K1, MAP2K2, LEF1, WNT11, CREB1, TCF7L2, MC1R, RAF1, FZD3, CREBBP, DCT, CTNNB1, PRKX, ADCY1, PRKACB, FZD10, CALML5, GSK3B, WNT8B, PLCB1, CAMK2G, GNAI1, CREB3L4, PRKACA, WNT5A, CALML6, EP300, MAPK1, CALML3, CREB3, CAMK2A, CALM3, FZD8, FZD6, WNT16, WNT2B, DVL1",0.374687549038326,0.0819696632151199,FALSE
+"H520","Input","KEGG_MELANOMA",0.48653,1.35,0.101,3954,0.656,"FGF3, FGF19, FGF4, IGF1, FGF21, FGF20, FGF9, MAP2K1, FGFR1, MAP2K2, PIK3CA, BRAF, RAF1, E2F2, PIK3CB, FGF22, FGF13, CDKN2A, PIK3R2, AKT2, E2F1",0.995678626217357,0.18309616062434,FALSE
+"H520","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.23149,0.648,0.953,3224,1,"UGT2A1, AKR1C1, AKR1C2, ALDH3A1, GSTA4, AKR1C3, CYP1A1, EPHX1, ADH5",0.0209070993616736,0,FALSE
+"H520","Input","KEGG_MISMATCH_REPAIR",0.37097,1.03,0.402,7112,0.823,"RFC4, POLD3, EXO1, RFC1, PMS2, RFC5, RPA4, MSH6, POLD2, RPA2, RFC3, RPA3, MSH2, RFC2",0.39577394691553,0.0846001647877302,FALSE
+"H520","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.53531,1.48,0.0511,3881,0.663,"IGF1, EIF4EBP1, RPS6KA6, TSC2, PIK3CA, PDPK1, BRAF, STK11, MLST8, EIF4E, ULK1, MTOR, DDIT4, EIF4E2, PIK3CB, ULK3, RPS6KA2, VEGFA, RPS6KB2, RPS6, PIK3R2, EIF4B, AKT2",1.29157909986529,0.178486471595227,FALSE
+"H520","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.25675,0.711,0.87,2852,1,"IFNA5, SYK, PRF1, PAK1, NFATC3, MAP2K1, ULBP1, MAP2K2, PIK3CA, PTPN11, BRAF, IFNAR1, RAF1, FYN, SOS1, PPP3R1, PIK3CB",0.0604807473813815,0,FALSE
+"H520","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.39605,1.1,0.318,2107,0.892,"GPR50, GRM8, GRIK3, GPR83, GRM3, NMUR2, CHRM3, OPRD1, GABRA3, PTH2R, ADRA2C, HTR2C, GABRR2, LPAR6, SCTR, GABRG2, MCHR2, GABRR1, CHRNA7, P2RY11, GALR2, PTGER4, GABRQ, GALR3, LTB4R2, MC1R, LTB4R, P2RY14, ADRB1",0.497572880015567,0.0496351456238769,FALSE
+"H520","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.21165,0.592,0.961,5375,1,"MAP2K5, SH2B1, MAP2K1, ATF4, MAP2K7, MAP2K2, RPS6KA6, PIK3CA, PTPN11, PDPK1, BRAF, RAF1, MAPK9, SOS1, PIK3CB, RPS6KA2, RIPK2, NFKBIB, CALML5, GSK3B, SOS2, PIK3R2, AKT2, CAMK2G, PRDM4, IRAK1, CRKL, NTRK2, BEX3, FASLG, CALML6, TP73, PSEN1, MAPK1",0.0172766123314547,0,FALSE
+"H520","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.27808,-1.01,0.365,15820,0.725,"NT5M, PNP, BST1, NAMPT, NT5C2, AOX1, ENPP1, QPRT, NMNAT2, NNMT, NT5E",0.437707135543525,0.139661993429006,FALSE
+"H520","Input","KEGG_NITROGEN_METABOLISM",0.56754,1.58,0.0328,1340,0.754,"CA6, CA7, GLUD2, CA8, ASNS",1.48412615628832,0.122628654130226,FALSE
+"H520","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29362,-1.09,0.253,16189,0.746,"NLRP3, NOD1, IKBKB, CCL5, IL1B, TNFAIP3, TAB3, IL6, CXCL1, MAPK11, CXCL2, CASP1, CXCL8, BIRC3, CARD6, IL18, NLRP1, TRIP6",0.596879478824182,0.127261172527331,FALSE
+"H520","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.46733,1.31,0.117,7316,0.592,"XRCC5, RAD50, POLL, DNTT, MRE11, FEN1, LIG4, DCLRE1C, NHEJ1, XRCC6",0.931814138253838,0.22767829327708,FALSE
+"H520","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26708,0.751,0.857,5613,1,"MAP2K1, MAP2K2, PIK3CA, PDPK1, BRAF, RAF1, SOS1, E2F2, PIK3CB, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, RB1, TGFA, CDK6, EGF, MAPK1, E2F3",0.0670191780768018,0,FALSE
+"H520","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.37491,1.03,0.409,5494,0.823,"DVL3, MAML1, MAML2, CTBP1, LFNG, CREBBP, CIR1, RFNG, APH1A, PSEN2, DTX3, MAML3, KAT2A, EP300, HDAC2, ADAM17, PSEN1, SNW1, CTBP2",0.388276691992658,0.0846001647877302,FALSE
+"H520","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.33699,0.93,0.562,5873,0.953,"RFC4, POLD3, ERCC4, RAD23A, GTF2H3, ERCC3, CUL4B, RFC1, CCNH, POLE, RFC5, RPA4, POLE4, XPC, DDB2, POLE3, POLD2, RPA2, DDB1, RFC3",0.250263684430939,0.0209070993616736,FALSE
+"H520","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.38059,1.05,0.382,6489,0.867,"MGAT5, MAN1A1, MAN2A1, B4GALT2, ALG3, RPN1, ST6GAL1, MOGS, ALG9, ALG13, STT3B, MAN2A2, B4GALT3, RPN2, ALG1, GANAB, DOLPP1, ALG10B, MGAT4A, ALG5, ALG12, RFT1, MAN1C1, MGAT4B, STT3A",0.417936637088291,0.0619809025237897,FALSE
+"H520","Input","KEGG_OLFACTORY_TRANSDUCTION",0.37001,1.02,0.412,1297,0.828,"OR10S1, OR6T1, OR4D5, OR2B3, OR6B2, OR5M11, OR10AD1, OR11H6, OR8S1, OR10AG1, OR13J1, GNAL, OR1J1",0.385102783966865,0.0819696632151199,FALSE
+"H520","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.56465,1.56,0.0245,6339,0.711,"MTHFD2, SHMT2, ALDH1L1, GART, MTHFD1L, MTHFD2L, MTHFR, MTFMT, FTCD, DHFR, MTHFS",1.61083391563547,0.148130399270234,FALSE
+"H520","Input","KEGG_OOCYTE_MEIOSIS",0.41586,1.16,0.238,5042,0.77,"IGF1, ADCY7, ITPR1, PPP2CA, MAP2K1, CDC23, RPS6KA6, PPP1CC, ESPL1, CDC20, CCNB2, CDK1, PLK1, PPP2R1B, CDC25C, STAG3, PPP3R1, MAD2L1, PKMYT1, RPS6KA2, PRKX, ANAPC7, ADCY1, PRKACB, ANAPC1, PPP2R5E, CALML5, SGO1, PPP1CB, CDC27, BUB1, AR, MAD2L2, CAMK2G, FBXW11, PPP2R5D, SKP1, ANAPC11, PRKACA, CALML6",0.623423042943488,0.113509274827518,FALSE
+"H520","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.46682,-1.71,0.0426,17370,0.725,"MAN2B2, GLB1, HEXB, NEU1, FUCA1",1.37059040089728,0.139661993429006,FALSE
+"H520","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.40796,1.14,0.242,5601,0.821,"ATP4A, NDUFS5, ATP6V0B, ATP5ME, ATP6V0A2, ATP6V1E2, NDUFS7, NDUFB10, PPA1, COX4I1, COX11, UQCR11, SDHB, NDUFA2, NDUFA10, ATP5F1D, NDUFA11, NDUFA9, COX7C, COX7A2L, NDUFA7, ATP6V1G2, ATP5F1C, ATP6V0C, UQCRQ, ATP6V1H, NDUFA4L2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, NDUFB7, UQCRC2, NDUFS6, NDUFA4, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, ATP6V0E2, ATP6V0A1, NDUFB1, NDUFC1, UQCRB, ATP6V1A, ATP5F1A, NDUFV1, NDUFB5",0.616184634019569,0.0856568428805592,FALSE
+"H520","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.38591,1.08,0.349,1096,0.928,"GALNT10, GALNT13, GCNT1, GALNT6",0.45717457304082,0.0324520237811379,FALSE
+"H520","Input","KEGG_P53_SIGNALING_PATHWAY",0.29023,0.806,0.756,2571,1,"IGF1, GADD45G, SESN2, SIAH1, RPRM, COP1, TSC2, CCNB2, CDK1, TP53AIP1, CHEK1, CCNG1, ATM",0.121478204498793,0,FALSE
+"H520","Input","KEGG_PANCREATIC_CANCER",-0.29123,-1.06,0.374,17729,0.751,"RALBP1, RALGDS, TGFB3, PGF, VEGFC, JAK1, RAC2, TP53, PIK3CD, CDC42, PLD1, TGFB1, ERBB2, EGFR, TGFBR2, RALB",0.42712839779952,0.124360062995832,FALSE
+"H520","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.28974,0.811,0.761,6096,1,"PANK3, PPCDC, COASY, PPCS, PANK4, PANK1, PANK2",0.118615343229427,0,FALSE
+"H520","Input","KEGG_PARKINSONS_DISEASE",0.40031,1.11,0.296,6850,0.873,"NDUFS5, SLC18A2, SLC25A4, NDUFS7, NDUFB10, COX4I1, UQCR11, SDHB, NDUFA2, VDAC2, NDUFA10, VDAC1, ATP5F1D, NDUFA9, COX7C, COX7A2L, NDUFA7, SLC25A5, ATP5F1C, UQCRQ, PPID, UCHL1, NDUFA4L2, UBE2J2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, NDUFB7, UQCRC2, PARK7, NDUFS6, NDUFA4, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, NDUFB1, NDUFC1, UQCRB, ATP5F1A, NDUFV1, NDUFB5, UBE2J1, UBE2L6, PINK1, CASP9, UQCRFS1, COX8A, NDUFS1, NDUFA6, CASP3, COX6A1, SNCA, COX7B, ATP5MC2",0.528708288941061,0.0589857562944303,FALSE
+"H520","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.32967,-1.18,0.214,16265,0.766,"TUBB8, ACTG1, TLR4, TUBB4B, TLR5, TUBB, ARPC5, PRKCA, ARPC1B, ARPC2, CLDN1, ITGB1, CDC42, TUBB6, ACTB, RHOA, TUBA4A",0.669586226650809,0.115771230367396,FALSE
+"H520","Input","KEGG_PATHWAYS_IN_CANCER",0.28208,0.787,0.795,4222,1,"FGF3, FGF19, FGF4, IGF1, ZBTB16, FGF21, KITLG, CTNNA2, DVL3, AXIN2, TCF7, FGF20, SHH, FGF9, APC, FZD1, RUNX1, MAP2K1, FGFR1, DAPK2, MAP2K2, LEF1, VHL, WNT11, CTBP1, TCF7L2, LAMC1, PIK3CA, TGFB2, BRAF, RAF1, FZD3, PIAS4, MAPK9, CREBBP, PTCH2, MTOR, CTNNA1, EGLN2, CBL, SOS1, SMAD4, FGFR3, XIAP, EGLN1, E2F2, AXIN1, PIK3CB, CTNNB1, RAD51, ELOB, FH, VEGFA, SKP2, FGF22, TRAF4, SLC2A1, FZD10, FGF13, CKS1B, BIRC5, ARNT, ARNT2, CDKN2A, GSK3B, APPL1, SOS2, PIK3R2, AKT2, TPR, BMP4, E2F1, EPAS1, TGFBR1, WNT8B, AR, RAC3, RB1, PTK2",0.0996328713435297,0,FALSE
+"H520","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.25667,0.725,0.878,2705,1,"UGT2A1, DCXR",0.0565054840938974,0,FALSE
+"H520","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.323,-1.17,0.185,18666,0.692,"DERA, PFKP, PGM1",0.732828271596986,0.159893905543242,FALSE
+"H520","Input","KEGG_PEROXISOME",0.35016,0.974,0.495,2893,0.906,"HAO2, PIPOX, PRDX1, SOD1, MPV17L, PEX12, PEX2, IDH1, PECR, SLC27A2, PEX14, PEX5, PEX11G, ABCD4, PEX16",0.305394801066431,0.0428718023231869,FALSE
+"H520","Input","KEGG_PHENYLALANINE_METABOLISM",0.50311,1.4,0.0756,1326,0.533,"PAH, GOT2, MAOB, ALDH3A1",1.12147820449879,0.273272790973428,FALSE
+"H520","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.27782,0.779,0.799,6125,1,"DGKQ, ITPR1, PIP4K2B, DGKG, PIK3CA, OCRL, INPPL1, PIK3CB, PIKFYVE, PIK3C3, CDIPT, CALML5, INPP5J, PLCD4, PIK3C2A, PIK3R2, ITPKB, PLCB1, IMPA1, DGKE, PIK3C2B, PI4KB, CALML6, PIP5K1A, INPP5B, CDS1, PIP5K1C, CALML3, INPP5E, INPP4A, CALM3, PIK3R3",0.0974532206860086,0,FALSE
+"H520","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.40398,1.12,0.287,2577,0.855,"UROD, UGT2A1, EARS2, FECH, HMBS",0.542118103266008,0.0680338852718274,FALSE
+"H520","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.32613,0.91,0.601,3610,0.962,"ADIPOQ, UCP1, SORBS1, PCK2, PDPK1, GK, ME1, LPL, SLC27A2, FADS2, NR1H3, SLC27A5",0.22112552799726,0.0168249279621871,FALSE
+"H520","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.27586,-0.959,0.429,17295,0.723,"ACOX2, CYP39A1, SCP2",0.367542707815276,0.140861702705469,FALSE
+"H520","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.19981,0.552,0.983,4361,1,"RFXAP, TNFRSF13C, RAG1, RFX5, IGLL1, CD8A",0.00744648216786438,0,FALSE
+"H520","Input","KEGG_PRION_DISEASES",0.35537,0.984,0.499,5375,0.888,"SOD1, MAP2K1, MAP2K2, LAMC1, FYN, PRKX, PRKACB, NCAM1, STIP1, PRKACA, MAPK1",0.30189945437661,0.051587034221399,FALSE
+"H520","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.43344,1.2,0.196,4986,0.731,"IGF1, ADCY7, MAP2K1, CDC23, FZR1, RPS6KA6, PIK3CA, BRAF, CCNB2, CDK1, RAF1, PLK1, MAPK9, CDC25C, MAD2L1, PKMYT1, PIK3CB, RPS6KA2, PRKX, ANAPC7, ADCY1, PRKACB, ANAPC1, PDE3B, PIK3R2, AKT2, CDC27, BUB1, MAD2L2, GNAI1, ANAPC11, PRKACA, CCNA2",0.707743928643524,0.13608262304214,FALSE
+"H520","Input","KEGG_PROPANOATE_METABOLISM",0.44919,1.27,0.153,5901,0.649,"ACSS3, ALDH2, ACACA, ALDH9A1, HADHA, HIBCH, ALDH3A2, ACACB, ALDH6A1, ALDH7A1, PCCB, EHHADH, MLYCD, SUCLA2, SUCLG1, MCEE, ACAT1",0.815308569182401,0.187755303199631,FALSE
+"H520","Input","KEGG_PROSTATE_CANCER",0.3433,0.949,0.524,4584,0.933,"IGF1, TCF7, MAP2K1, FGFR1, ATF4, MAP2K2, LEF1, CREB1, TCF7L2, PIK3CA, PDPK1, BRAF, RAF1, CREBBP, MTOR, SOS1, E2F2, PIK3CB, CTNNB1, GSK3B, SOS2, PIK3R2, AKT2, E2F1, AR, RB1, CREB3L4, TGFA",0.280668713016273,0.0301183562535,FALSE
+"H520","Input","KEGG_PROTEASOME",0.28788,0.803,0.774,7640,1,"PSMD7, PSMD2, PSMB11, PSMD11, PSMD14, PSME4, PSMC3, PSME3, PSMD8, PSMA3, PSMA4, PSMD1, PSMC5, PSMB1, PSME2, PSMC6, PSMD3, PSMD6, PSMD4, PSMA2, PSMC2, PSMC1",0.111259039317107,0,FALSE
+"H520","Input","KEGG_PROTEIN_EXPORT",0.46945,1.31,0.111,3508,0.592,"SRPRB, IMMP1L, SRP19, SEC63, SEC61A1, SEC11A, SRP9, SEC62, SEC11C",0.954677021213343,0.22767829327708,FALSE
+"H520","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.37818,1.05,0.364,1596,0.867,"GLUD2, PCK2, SLC25A10",0.438898616350944,0.0619809025237897,FALSE
+"H520","Input","KEGG_PURINE_METABOLISM",0.34935,0.986,0.478,4730,0.895,"PDE8B, ENTPD8, ENTPD3, ENTPD1, PDE6B, ADCY7, PAPSS1, POLR2D, ALLC, GMPS, POLR3A, POLR2G, PDE4D, POLA1, POLD3, PDE5A, POLR2H, GART, NUDT2, PDE7A, POLR2C, POLR2E, RRM1, PRUNE1, PRPS2, ADCY1, NPR2, PDE3B, PPAT, POLR1E, POLR3G, GMPR, NME2, PAICS, NT5C3A, POLR2J, APRT, POLR1D, PDE11A, PRPS1, ADK, POLE, NT5C, POLR2K",0.320572103387881,0.048176964684088,FALSE
+"H520","Input","KEGG_PYRIMIDINE_METABOLISM",0.32743,0.918,0.588,4135,0.963,"ENTPD8, ENTPD3, ENTPD1, UCK2, POLR2D, POLR3A, POLR2G, DUT, POLA1, POLD3, POLR2H, CTPS1, NUDT2, CTPS2, POLR2C, DTYMK, POLR2E, RRM1, CAD, DHODH, UMPS, POLR1E, UCK1, POLR3G, NME2, NT5C3A, POLR2J, POLR1D",0.230622673923862,0.0163737128754655,FALSE
+"H520","Input","KEGG_PYRUVATE_METABOLISM",0.37537,1.04,0.39,4790,0.843,"PCK2, ALDH2, PDHA1, ACACA, HAGH, ACYP1, ALDH9A1, ME1, ALDH3A2, DLAT, ACACB, ALDH7A1, GRHPR",0.408935392973501,0.0741724253752577,FALSE
+"H520","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.2637,0.734,0.86,3904,1,"FGF3, FGF19, FGF4, CHRM3, FGF21, FGF20, PAK2, FGF9, APC, PAK1, PIP4K2B, MAP2K1, FGFR1, MYL5, MAP2K2, MYLK2, PIK3CA, PPP1CC, BRAF, RAF1, IQGAP3, SOS1, FGFR3, CYFIP2, GIT1, TIAM1, PIK3CB, PFN2, PIKFYVE, WAS, FGF22, FGF13, ACTN4, NCKAP1, CYFIP1, PPP1CB, SOS2, PIK3R2, DIAPH1",0.0655015487564323,0,FALSE
+"H520","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.47332,1.34,0.0905,3806,0.625,"IFNA5, ATG4D, ULK1, GABARAPL2, ATG4B, ULK3, PIK3C3, ATG12, IFNA21",1.0433514207948,0.204119982655925,FALSE
+"H520","Input","KEGG_RENAL_CELL_CARCINOMA",0.36288,1.01,0.434,4593,0.846,"PAK2, PAK1, MAP2K1, MAP2K2, VHL, PIK3CA, PTPN11, TGFB2, BRAF, RAF1, CREBBP, EGLN2, SOS1, EGLN1, PIK3CB, ELOB, FH, VEGFA, SLC2A1, ARNT, ARNT2, SOS2, PIK3R2, AKT2, EPAS1, VEGFD, TGFA, CRKL",0.362510270487489,0.0726296369609765,FALSE
+"H520","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.28008,0.77,0.813,4171,1,"THOP1, CMA1, NLN, MME",0.0899094544059319,0,FALSE
+"H520","Input","KEGG_RETINOL_METABOLISM",0.3055,0.862,0.674,4876,1,"UGT2A1, RDH11, CYP1A1, RDH12, ALDH1A1, ADH5, PNPLA4, CYP3A4, DHRS4, DHRS4L2, ALDH1A2, ADH6",0.17134010346468,0,FALSE
+"H520","Input","KEGG_RIBOFLAVIN_METABOLISM",0.50449,1.41,0.0691,2284,0.564,"MTMR2, RFK, ACP1, ACP4",1.1605219526258,0.248720896016658,FALSE
+"H520","Input","KEGG_RIBOSOME",0.18726,0.519,0.994,5341,1,"RPS8, RPS28, RSL24D1, RPL22, RPL35A, MRPL13, RPLP0, RPL23A, RPS15, RPS6, RPL36, RPS2, RPS24, RPL18A, RPL4, RPS15A, RPL17, RPL26L1, FAU, RPLP1",0.00261361560268669,0,FALSE
+"H520","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.20526,-0.769,0.835,17783,0.903,"MAPK11, CXCL8, IL12A, IRF3, TBK1, CASP10, TRADD, TBKBP1, IKBKE",0.0783135245163979,0.0443122496864942,FALSE
+"H520","Input","KEGG_RNA_DEGRADATION",0.54896,1.52,0.0483,4748,0.593,"CNOT1, EXOSC6, CNOT8, LSM1, CNOT6, DCP2, HSPA9, PAPOLG, EDC4, CNOT9, LSM7, EXOSC3, DCP1A, PARN, LSM3, EXOSC8, HSPD1, DCPS, DDX6, LSM4, XRN1, TENT4A, EDC3, CNOT7, CNOT6L, TTC37, EXOSC1, ENO3, EXOSC5, ZCCHC7",1.31605286924849,0.226945306635737,FALSE
+"H520","Input","KEGG_RNA_POLYMERASE",0.41161,1.16,0.247,4730,0.77,"POLR2D, POLR3A, POLR2G, POLR2H, POLR2C, POLR2E, POLR1E, POLR3G, POLR2J, POLR1D, POLR2K",0.607303046740334,0.113509274827518,FALSE
+"H520","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.51987,1.44,0.0633,2788,0.683,"LCMT1, PAPSS1, CBS, MAT2A, SEPHS2, MAT2B, LCMT2, SEPHS1, SCLY",1.19859628998265,0.165579296318467,FALSE
+"H520","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.28067,-0.998,0.477,15230,0.702,"PIK3R1, LAMC3, TRAF3, ITGA2, NFKBIA, ITGA2B, CCNE1, AKT3, IKBKB, MAX, LAMA1, LAMC2, PTGS2, ITGAV, COL4A2, TRAF5, LAMA4, LAMB2, RXRA, LAMA3, BIRC3, PIAS3, COL4A1, TP53, LAMA5, PIK3CD, ITGB1, LAMB3, ITGA3, LAMB1",0.321481620959886,0.153662887870195,FALSE
+"H520","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.37511,1.05,0.376,3953,0.867,"GOSR1, STX5, SEC22B, USE1, TSNARE1, VAMP1, STX6, SNAP47, VAMP2, STX10, BNIP1, STX17",0.424812155072339,0.0619809025237897,FALSE
+"H520","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.3388,-1.26,0.146,17158,0.68,"SPTLC1, SGMS1, PLPP1, SMPD1, GLB1, PLPP3, SGMS2, NEU1, UGCG, SPHK1, SMPD2",0.835647144215563,0.167491087293764,FALSE
+"H520","Input","KEGG_SPLICEOSOME",0.46757,1.31,0.108,5966,0.592,"PPIE, TRA2B, CTNNBL1, RBM17, ISY1, XAB2, PPIH, THOC3, SF3A2, LSM7, NCBP2, SNRPA, DHX8, SRSF5, HNRNPA1L2, LSM3, HNRNPM, SLU7, HNRNPU, HNRNPA1, USP39, RBMX, RBM22, SRSF3, SRSF10, SF3B1, THOC1, ZMAT2, DDX5, LSM4, BUD31, SRSF9, DHX38, TXNL4A, PRPF40A, U2SURP, DDX46, HSPA1L, THOC2, SRSF1, SMNDC1, AQR, CDC40, ALYREF, CHERP, SNRPF, SNRNP200, PRPF40B, HNRNPA3, SRSF8, SNRPG, SRSF2, PRPF3, DHX16, SART1, RBM8A, SNW1, MAGOHB, SRSF7, BCAS2, SF3A1, DDX42, SNRPD1, PLRG1, LSM5, HNRNPK, TCERG1, SNRPA1",0.96657624451305,0.22767829327708,FALSE
+"H520","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.23507,-0.88,0.636,16846,0.85,"UGDH, GYS1, ENPP1, UXS1, AMY2B, PYGB, PGM1",0.196542884351586,0.0705810742857073,FALSE
+"H520","Input","KEGG_STEROID_BIOSYNTHESIS",-0.39516,-1.4,0.121,16365,0.815,"SQLE, DHCR24, MSMO1, LIPA",0.91721462968355,0.0888423912600234,FALSE
+"H520","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38192,1.07,0.356,4734,0.91,"UGT2A1, AKR1C1, AKR1C2, SRD5A3, AKR1C3, CYP1A1, HSD17B12, CYP3A4, SRD5A1, HSD11B2, AKR1C4, HSD17B8, SULT1E1",0.448550002027125,0.0409586076789064,FALSE
+"H520","Input","KEGG_SULFUR_METABOLISM",0.42826,1.18,0.215,5228,0.759,"PAPSS1, SUOX, SULT1A3, BPNT1, SULT1E1, SULT1A4, SULT1A1",0.667561540084395,0.11975822410452,FALSE
+"H520","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.38175,-1.34,0.141,13039,0.687,"IL10, FCGR2B, FCGR2C, GRIN2A, C1R, C6, C4B, C2, GRIN2B, C7, SNRPB, ACTN1, TNF, ACTN2, C4A, FCGR1A, ELANE, C1S, TRIM21, FCGR2A, CD40, C3",0.85078088734462,0.16304326294045,FALSE
+"H520","Input","KEGG_TASTE_TRANSDUCTION",0.20059,0.561,0.982,5077,1,"GNB1, SCNN1A, PRKX, CACNA1B, PRKACB, TAS1R3, GNB3, GNG3, PRKACA, TAS2R46, TAS2R14",0.00788851221305034,0,FALSE
+"H520","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.53476,1.47,0.0499,2943,0.636,"ADO, CSAD, GAD1",1.30189945437661,0.196542884351586,FALSE
+"H520","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.25099,-0.899,0.578,4793,0.823,"GGPS1, ACAT1, ACAT2, PDSS1, MVD, IDI2, FDPS, PMVK, DHDDS, HMGCS1, MVK, HMGCR, HMGCS2, IDI1, PDSS2",0.238072161579471,0.0846001647877302,FALSE
+"H520","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.3788,1.06,0.373,6086,0.879,"BMP8A, NODAL, INHBE, INHBC, PPP2CA, AMH, BMP8B, ID4, SP1, TGFB2, THBS4, SMAD9, SMAD5, CREBBP, BMP7, SMAD4, PPP2R1B, SMAD1, INHBB, RBL1, ID3, RPS6KB2, E2F4, RBL2, BMP4, TGFBR1, SKP1, SMAD2, SMAD6, EP300, BMPR1A, MAPK1, SMAD7, MYC, BMPR2, ROCK2, CDKN2B, ACVR2B, RPS6KB1",0.428291168191312,0.0560111249262281,FALSE
+"H520","Input","KEGG_THYROID_CANCER",0.43985,1.24,0.178,1729,0.702,"TCF7, MAP2K1, MAP2K2, LEF1, TCF7L2, BRAF",0.749579997691106,0.153662887870195,FALSE
+"H520","Input","KEGG_TIGHT_JUNCTION",0.23182,0.649,0.941,4500,1,"MYH7B, CTNNA2, PRKCQ, PPP2CA, CSNK2A2, MYL5, RAB3B, MYH11, PPP2R2C, EPB41L3, PATJ, CTNNA1, PPP2R1B, CTNNB1, CRB3, ACTN4, PARD6A, MAGI1, LLGL2, F11R, AKT2, CLDN7, AFDN, PRKCZ, GNAI1, TJAP1, MYH3",0.0264103765727431,0,FALSE
+"H520","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.18983,0.528,0.997,4567,1,"IFNA5, MAP2K1, MAP2K7, MAP2K2, PIK3CA, MAP2K6, IFNAR1, MAPK9, MAP3K7, PIK3CB, SPP1, TIRAP, IFNA21, PIK3R2, AKT2, TAB1, MAP2K4, IRAK1",0.00130484168834428,0,FALSE
+"H520","Input","KEGG_TRYPTOPHAN_METABOLISM",0.35087,0.97,0.508,2805,0.906,"MAOB, WARS2, ALDH2, ALDH9A1, CYP1A1, HADH, HADHA, AFMID",0.294136287716081,0.0428718023231869,FALSE
+"H520","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.43421,1.21,0.194,3844,0.738,"CACNA1E, ADIPOQ, SOCS4, PIK3CA, MAPK9, MTOR, PIK3CB, KCNJ11, CACNA1B, HK2, ABCC8, SOCS1, PIK3R2",0.712198270069774,0.131943638176958,FALSE
+"H520","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.30032,0.832,0.735,4971,1,"PRF1, ICA1, HSPD1, GAD1, LTA, CPE, FASLG",0.133712660915805,0,FALSE
+"H520","Input","KEGG_TYROSINE_METABOLISM",0.33098,0.913,0.586,3224,0.965,"LCMT1, GOT2, MAOB, DBH, ALDH3A1, LCMT2, DCT, ADH5",0.232102383981909,0.0154726866562074,FALSE
+"H520","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.34281,0.944,0.55,4425,0.936,"CTLA4, MALT1, PAK2, PAK1, PRKCQ, NFATC3, MAP2K1, MAP2K7, MAP2K2, PIK3CA, PDPK1, RAF1, MAPK9, FYN, CBL, SOS1, MAP3K7, PPP3R1, PIK3CB, NFKBIB, NCK1, GSK3B, SOS2, PIK3R2, AKT2, PTPN6, CD8A, DLG1",0.259637310505756,0.0287241512618947,FALSE
+"H520","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.43433,1.2,0.188,5850,0.731,"UBE2NL, UBE2D2, UBE2QL1, CDC34, KEAP1, UBE2R2, UBE2I, UBE2B, SIAH1, CDC23, FZR1, WWP1, VHL, COP1, CDC20, MGRN1, CUL5, PIAS4, CBL, UBE3A, XIAP, UBE2N, WWP2, CUL3, UBA2, CUL4B, ELOB, ANAPC7, SYVN1, HERC2, HERC1, KLHL9, SKP2, ANAPC1, UBE2Q1, SOCS1, UBE2J2, UBE2A, CDC27, STUB1, FANCL, UBE4B, FBXW11, RNF7, PIAS2, UBE2D3, SKP1, UBE2W, TRIM37, UBE2K, FBXW7, UBR5, ANAPC11, UBE2S, UBE4A, UBE2O, DDB2, PIAS1, BIRC6, MID1, TRIP12, BRCA1, UBE2J1, DDB1, UBE2M, FBXW8",0.72584215073632,0.13608262304214,FALSE
+"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.47841,1.33,0.0952,7811,0.603,"PDHA1, LARS2, IARS2, BCAT2, BCAT1, VARS2",1.02136305161553,0.219682687859849,FALSE
+"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37206,1.04,0.403,6698,0.843,"OXCT2, ACAA2, ALDH2, ALDH9A1, HADH, HADHA, HIBCH, BCKDHA, ALDH3A2, IVD, ACAD8, ALDH6A1, DBT, MCCC2, MCCC1, ALDH7A1, ACADSB, PCCB, EHHADH, MCEE, ACAT1, BCKDHB, HSD17B10, OXCT1, ECHS1",0.39469495385889,0.0741724253752577,FALSE
+"H520","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.24862,0.697,0.905,3711,1,"ADCY7, ITPR1, PRKCQ, MAP2K1, MAP2K2, MYLK2, MYH11, PPP1CC, BRAF, GNA11, RAF1, KCNMA1, PLA2G12A, PRKX, ARHGEF11, KCNMB3, ADCY1, NPR2, PRKACB, CALML5, PLA2G3, PPP1CB",0.0433514207947967,0,FALSE
+"H520","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.34212,0.964,0.52,5771,0.9,"DYNC1I1, DYNC1LI2, RAB11B, DCTN5, CREB1, DCTN4, PRKX, VAMP2, PRKACB, RAB11A, CREB3L4, DYNLL2, PRKACA, DYNC1H1, RAB5A, CREB3, DCTN1",0.283996656365201,0.0457574905606751,FALSE
+"H520","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.21206,-0.746,0.778,16861,0.865,"SH2D2A, PTGS2, NOS3, NFATC2, PLCG2, PRKCA, MAPK11, NFATC1, RAC2, PIK3CD, CDC42, HSPB1, SPHK1, PXN",0.109020403010311,0.0629838925351858,FALSE
+"H520","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25291,-0.922,0.532,17236,0.79,"ATP6V1E1, PDIA4, PLCG2, ERO1A, GNAS, ATP6V1B1, PRKCA, ATP6V1G1, ADCY9, ATP6V1F, ACTB, KDELR3, TCIRG1",0.274088367704952,0.102372908709559,FALSE
+"H520","Input","KEGG_VIRAL_MYOCARDITIS",0.24931,0.698,0.897,2208,1,"MYH7B, PRF1, MYH11, SGCG, FYN",0.0472075569559079,0,FALSE
+"H520","Input","KEGG_WNT_SIGNALING_PATHWAY",0.37476,1.06,0.378,6720,0.879,"NKD1, WIF1, DKK2, DVL3, TBL1XR1, AXIN2, TCF7, SENP2, APC, PPP2CA, CSNK2A2, SIAH1, NFATC3, FZD1, NLK, TBL1X, LEF1, WNT11, CTBP1, TCF7L2, FZD3, MAPK9, CREBBP, SMAD4, MAP3K7, LRP6, PPP2R1B, NKD2, PPP3R1, AXIN1, CACYBP, CTNNB1, PRKX, RUVBL1, PRKACB, PPP2R5E, FZD10, GSK3B, WNT8B, RAC3, PLCB1, CAMK2G, FBXW11, PPP2R5D, SKP1, FRAT2, LRP5, SMAD2, CSNK2A1, PRKACA, WNT5A, PPARD, EP300, FRAT1, PSEN1, SFRP5, CTBP2, MYC, CSNK1E, ROCK2, CAMK2A, VANGL1, PPP2R5C, FZD8, FZD6, PPP2R5A, WNT16, WNT2B, DVL1, JUN, NFATC4, DVL2, NFAT5, CHD8, MAPK8, WNT6",0.422508200162775,0.0560111249262281,FALSE
+"H460","Input","KEGG_ABC_TRANSPORTERS",0.42084,1.55,0.0687,3238,0.202,"ABCC9, ABCB10, ABCC2, ABCA8, ABCG2, ABCB6, ABCB7, TAP2, ABCB1, ABCC3, ABCB8, ABCA2, ABCC1",1.16304326294045,0.694648630553376,FALSE
+"H460","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.49963,-1.72,0.0358,16075,0.31,"LEF1, TCF7, SOS1, RARA, RUNX1, RAF1, STAT5A, PIM1, KRAS, PIK3CD, RPS6KB2, PIK3R3, AKT2, NRAS, RELA, BRAF, MAPK3, MAPK1, TCF7L1, SOS2, PPARD, STAT3, PIK3CA",1.44611697335613,0.508638306165727,FALSE
+"H460","Input","KEGG_ADHERENS_JUNCTION",-0.51863,-1.8,0.0127,16075,0.493,"LEF1, PTPRF, TCF7, PTPRB, AFDN, CDH1, BAIAP2, RAC1, SORBS1, EP300, MAP3K7, RAC2, MAPK3, INSR, CTNND1, MAPK1, PTPN1, CDC42, NECTIN2, TCF7L1, CREBBP, NLK, SMAD3, WASF2, NECTIN3, TGFBR2, LMO7, CSNK2B, FYN, CSNK2A1",1.89619627904404,0.30715308072277,FALSE
+"H460","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.24182,-0.844,0.663,16420,0.835,"MAPK10, PRKAB1, ACSL5, AKT2, RELA, ADIPOR2, NFKBIE, PPARA, CPT1B, MAPK8, STAT3, RXRB",0.178486471595227,0.0783135245163979,FALSE
+"H460","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.31223,1.12,0.26,2951,0.407,"CPS1, GOT2, CAD, ADSL, ASS1, PPAT, GOT1",0.585026652029182,0.39040559077478,FALSE
+"H460","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.3695,-1.28,0.17,11790,0.427,"FXYD2, SCNN1G, KCNJ1, ATP1B2, PIK3R2, HSD11B1, SCNN1B, PDPK1, PIK3CB, PRKCG, PIK3R1, ATP1A1, NR3C2, NEDD4L, SCNN1A, KRAS, PIK3CD, PIK3R3, MAPK3, INSR, MAPK1, PIK3CA",0.769551078621726,0.369572124974976,FALSE
+"H460","Input","KEGG_ALLOGRAFT_REJECTION",0.34225,1.23,0.207,12576,0.338,"CD40, FAS, IL12A, CD86, CD80, PRF1, IFNG, CD40LG, IL2, CD28, GZMB, FASLG, IL5, IL4, IL10, IL12B, TNF",0.684029654543082,0.471083299722345,FALSE
+"H460","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.24553,-0.842,0.662,18188,0.827,"PLA2G6, ACOX3",0.1791420105603,0.0824944904474534,FALSE
+"H460","Input","KEGG_ALZHEIMERS_DISEASE",0.39065,1.37,0.123,3200,0.276,"CASP7, ATP5F1B, NDUFB10, SNCA, CASP9, NAE1, NDUFS2, ATP5MC1, HSD17B10, UQCRC2, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, NDUFB8, COX7C, CALM1, NDUFA5, NDUFA1, PLCB1, COX5A, COX7B, ITPR1, MAPT, IDE, GAPDH, NDUFB3, UQCRQ, NDUFB1, COX5B, CASP8, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, TNFRSF1A, NDUFS7, ATF6, NDUFV3, ATP5MC2, ATP5F1D, NDUFS4, NDUFA7, NDUFC1, COX6A1, COX6B1, UQCRH, PSEN2, CYCS, BACE2, SDHD, NDUFS5",0.910094888560602,0.559090917934782,FALSE
+"H460","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.6345,2.32,0.00617,1069,0.0689,"IARS2, MARS2, FARSB, EARS2, DARS2, MTFMT, HARS2, LARS2, TARS2",2.20971483596676,1.16178077809237,TRUE
+"H460","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.23375,0.845,0.59,4169,0.741,"UGDH, GPI, GALK2, PMM2, GNPDA1, GNPDA2, GNPNAT1, NANS, PGM2, HK1, HK2, NPL, NANP, GALE",0.229147988357856,0.130181792020672,FALSE
+"H460","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.28873,-0.998,0.418,16132,0.657,"DERL1, CCS, PPP3CB, APAF1, MAPK13, CASP1, PPP3CA, RAC1, MAPK14, BCL2L1, RAB5A, CAT",0.378823718224965,0.182434630440219,FALSE
+"H460","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.35367,1.27,0.167,1789,0.329,"HSP90AA1, CTSL, CANX, IFNA21, HSP90AB1, HSPA5, PSME3, HSPA1A, HSPA8, HSPA1B, TAP2, HSPA4",0.777283528852417,0.482804102050026,FALSE
+"H460","Input","KEGG_APOPTOSIS",0.22691,0.825,0.658,1947,0.755,"CASP7, CASP9, AIFM1, NTRK1, IKBKG, ENDOG, TNFRSF10A, IRAK1, TRADD, BCL2, AKT1, PRKX, PRKAR1A, CHUK, CASP8",0.181774106386044,0.122053048370812,FALSE
+"H460","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.46452,1.68,0.0538,656,0.169,"HPGDS, PLA2G4A, AKR1C3, GGT1, PTGES2, GPX3",1.26921772433361,0.772113295386326,FALSE
+"H460","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.42754,1.51,0.0717,1837,0.21,"CPS1, GOT2, ALDH9A1, ODC1, ALDH18A1, CKB, SRM, LAP3, PYCR2, ALDH3A2, P4HA3, AGMAT, ALDH1B1, PYCR1",1.1444808443322,0.677780705266081,FALSE
+"H460","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.26891,-0.929,0.527,11469,0.718,"SGCG, CACNG6, SGCA, CTNNA2, DAG1, SGCD, ITGB8, CACNG7, ITGA11, LAMA2, ITGA9, ACTN4, ITGB7, CACNA2D4, PKP2, CTNNB1, ITGA10, ITGA1, CACNA1D, CACNB4, ITGA4, ITGB1, CACNB3, LEF1, TCF7, ITGB6, ITGB3, ITGB4, ITGAV, ITGA7, ITGA2, CDH2, TCF7L1, DSP, ITGA3",0.278189384787453,0.1438755557577,FALSE
+"H460","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56121,2,0.00326,1779,0.0953,"UGDH, ALDH9A1, ALDH3A2, ALDH1B1",2.48678239993206,1.02090709936167,TRUE
+"H460","Input","KEGG_ASTHMA",-0.30735,-1.06,0.341,7286,0.617,"CD40LG, IL3, CCL11, IL5, IL4, IL10, PRG2, EPX, FCER1G, RNASE3, TNF, IL13",0.467245621007502,0.209714835966758,FALSE
+"H460","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.33144,1.19,0.187,11222,0.333,"IFNA21, TPO, CD40, FAS, CD86, CD80, IFNA4, PRF1, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, CD28, GZMB, TSHR, FASLG, IL5, TSHB, IFNA13, IL4, CTLA4, IL10, CGA, IFNA8, IFNA1, IFNA5",0.728158393463501,0.47755576649368,FALSE
+"H460","Input","KEGG_AXON_GUIDANCE",-0.37738,-1.32,0.124,15092,0.389,"PAK4, SEMA6A, SLIT3, SEMA4D, RASA1, EPHB6, PLXNB2, PLXNC1, PLXNA3, CXCR4, ITGB1, CDK5, PLXNA1, SRGAP1, NCK2, SEMA3F, PTK2, SLIT2, EFNB3, RND1, GNAI3, PPP3CB, GSK3B, SEMA4A, KRAS, SEMA3B, PAK6, ABLIM3, PAK2, CFL1, SEMA4B, PPP3CA, RAC1, NRAS, ROCK1, RAC2, EPHA1, MAPK3, SEMA4C, MAPK1, EFNB2, EPHB3, NRP1, CDC42, SRGAP3, SEMA7A, ARHGEF12, SEMA3C, NFAT5, PLXNB1, EPHB2, FYN",0.906578314837765,0.410050398674292,FALSE
+"H460","Input","KEGG_BASAL_CELL_CARCINOMA",-0.33368,-1.16,0.244,12943,0.527,"WNT8B, WNT6, WNT16, PTCH1, PTCH2, HHIP, FZD1, WNT7A, WNT5B, CTNNB1, WNT4, AXIN2, APC2, STK36, WNT2B, WNT10A, LEF1, TCF7, FZD2, SUFU, APC, FZD6, GSK3B, WNT9A, BMP4, WNT7B, TCF7L1, DVL3",0.612610173661271,0.278189384787453,FALSE
+"H460","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.21663,0.796,0.736,1987,0.786,"GTF2H2, GTF2E2, GTF2A2, TAF9, TAF9B, TAF5",0.133122185662501,0.104577453960592,FALSE
+"H460","Input","KEGG_BASE_EXCISION_REPAIR",0.56649,2.02,0.0177,2985,0.0963,"NEIL3, APEX1, POLE3, PARP1, MPG, POLD2, NTHL1, POLE2, PARP2, LIG3, HMGB1, NEIL2, APEX2, LIG1, TDG, PCNA, SMUG1, UNG, POLE, POLD1",1.75202673363819,1.01637371287547,TRUE
+"H460","Input","KEGG_BETA_ALANINE_METABOLISM",0.36169,1.32,0.138,1898,0.311,"ALDH9A1, SRM, ECHS1, ALDH3A2, AOC3, ALDH1B1, HADHA",0.860120913598763,0.507239610973163,FALSE
+"H460","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29982,1.08,0.327,3570,0.436,"ELOVL6, HADHA, FADS1, ACOT2, SCD, HSD17B12, ACOT1, ACOT4, FADS2, HACD1",0.485452247339714,0.360513510731414,FALSE
+"H460","Input","KEGG_BLADDER_CANCER",-0.42156,-1.47,0.0697,16325,0.434,"DAPK2, DAPK3, RAF1, KRAS, CDH1, MMP2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, DAPK1, VEGFA, VEGFB, THBS1",1.15676722190199,0.362510270487489,FALSE
+"H460","Input","KEGG_BUTANOATE_METABOLISM",0.40645,1.45,0.0872,2010,0.235,"AKR1B10, PDHA1, ALDH9A1, L2HGDH, HADH, ECHS1, ALDH3A2, ALDH1B1, HADHA, ACAT1",1.05948351506743,0.628932137728264,FALSE
+"H460","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.4405,-1.53,0.0568,15329,0.388,"DAPP1, RASGRP3, SYK, CD22, SOS1, LILRB3, RAF1, PPP3CB, GSK3B, KRAS, PIK3CD, JUN, PIK3R3, PPP3CA, RAC1, AKT2, NRAS, RELA, CD72, NFKBIE, RAC2, MAPK3, IFITM1, MAPK1, SOS2, NFAT5, BCL10, PIK3CA",1.24565166428898,0.411168274405793,FALSE
+"H460","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.20838,0.75,0.815,1786,0.844,"PDE1A, P2RX5, SLC25A6, VDAC1, SLC25A5, ADCY7, PHKA1, VDAC2, TBXA2R, PDE1C, NTSR1, CALM1, PTK2B, PLCB1, P2RX6, PPID, ITPR1, ADCY3, PRKX, PHKB, ATP2B1, BST1",0.0888423912600234,0.073657553374345,FALSE
+"H460","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.25388,0.897,0.52,3067,0.66,"CACNA2D3, UQCRC2, TPM3, COX7C, COX5A, COX7B, UQCRQ, COX5B, CACNB2, UQCRHL, ATP1B3, COX6A1, COX6B1, RYR2, UQCRH",0.283996656365201,0.180456064458131,FALSE
+"H460","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.19249,0.688,0.916,734,0.934,"CD226, MPZ, NRCAM, CNTN1",0.0381045263321496,0.0296531237699066,FALSE
+"H460","Input","KEGG_CELL_CYCLE",0.26094,0.972,0.452,3732,0.572,"YWHAE, GADD45G, ANAPC1, SMAD2, ANAPC5, MCM6, ANAPC7, E2F4, BUB3, CDC25A, SMC1A, YWHAG, PTTG1, PLK1, ORC1, CDC26, MCM7, CCNB1, MCM4, CCNH, BUB1, PKMYT1, SKP2, BUB1B, CUL1, ORC2, STAG2, CDK1, PCNA, SFN, ORC6, CDK7, E2F2, MYC, CDC45, CDC6, SMC3, ORC5, CDC25B, MAD2L1, CHEK2, CCND3, ESPL1, CDC23, ANAPC2, CCNA2, ORC4, CDC7, ANAPC11, CCNB2",0.344861565188618,0.242603971206976,FALSE
+"H460","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.26526,-0.921,0.526,13226,0.725,"ADCY4, WASL, GNG3, VAV3, ROCK2, DOCK2, CXCL12, GRK4, PIK3CB, VAV1, XCL1, PRKCD, PRKCZ, NFKBIA, PIK3R1, CXCR6, ARRB1, GRK3, ADCY5, CCL26, JAK2, PXN, RASGRP2, CCL5, GNB1, GNG7, CX3CL1, CXCR4, CCL2, GNG2, GSK3A, SOS1, GNG4, SHC2, PTK2, TIAM1, RAF1, GNAI3, GNG5, GSK3B, CRKL, KRAS, PIK3CD, CCL28, PIK3R3, GRK5, RAC1, PRKACA, PREX1, AKT2, NRAS, RELA, BRAF, ROCK1, RAC2, MAPK3, MAPK1, CDC42, RAP1A, ADCY6, SOS2, BCAR1, TIAM2, STAT3, STAT2, PIK3CA, FOXO3",0.279014255846261,0.139661993429006,FALSE
+"H460","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.50074,-1.75,0.023,16534,0.375,"SHC2, RUNX1, RAF1, STAT5A, CRKL, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, RELA, BRAF, MAPK3, CBLB, MAPK1, CDKN2A, SMAD3, CBL, MECOM, BCL2L1, GAB2, TGFBR2, SOS2, HDAC1, PIK3CA, CDKN1B",1.63827216398241,0.425968732272281,FALSE
+"H460","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.55384,-1.93,0.0149,17307,0.764,"NR1D1, CSNK1E, ARNTL, PER3, CRY2",1.82681373158773,0.11690664142431,FALSE
+"H460","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.64971,2.28,0.00817,3190,0.059,"FH, PDHA1, IDH3A, CS, SUCLG1, DLD, DLAT, MDH2, DLST, IDH1, IDH3B, IDH3G, ACLY, SDHC, SDHB, OGDH, ACO2, PDHB, SDHD",2.08777794346758,1.22914798835786,TRUE
+"H460","Input","KEGG_COLORECTAL_CANCER",-0.40113,-1.4,0.0999,16075,0.397,"LEF1, TCF7, MAPK10, APC, RAF1, GSK3B, KRAS, PIK3CD, JUN, PIK3R3, RAC1, AKT2, BRAF, RAC2, MAPK3, MAPK1, TCF7L1, SMAD3, MAPK8, TGFBR2, PIK3CA",1.00043451177402,0.401209493236885,FALSE
+"H460","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.23859,-0.839,0.671,13582,0.823,"SERPINA5, VWF, C3, C3AR1, MASP2, C4BPB, F8, SERPINF2, C2, BDKRB1, C1R, CFI, SERPING1, SERPINE1, C4B, SERPINA1, F2R, BDKRB2, C4A, F3, C5, CFB, CD59",0.173277479831008,0.0846001647877302,FALSE
+"H460","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.43015,1.56,0.0642,3562,0.211,"GOT2, AHCY, SRM, AHCYL2, MAT2A, LDHA, ENOPH1, LDHB, DNMT1, GOT1, MTAP, CTH, MTR, SMS, AHCYL1",1.19246497193115,0.675717544702307,FALSE
+"H460","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.1737,0.61,0.948,1310,0.99,"TNFRSF8, IL18RAP, CXCL5, OSM, FLT4, IL18R1, CD70, CXCL1, IFNA21, EGF, CSF2RA, PF4V1, TNFSF9, IL22RA1, EDA2R, TNFRSF10A, CXCL8, IL6, CXCL2",0.0231916626619338,0.00436480540245009,FALSE
+"H460","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.28,1.02,0.367,3016,0.512,"POLR3K, POLR3G, IFNA21, IKBKG, TREX1, IL6, POLR3B, CHUK, POLR3D, POLR3GL, POLR3A, TBK1, ADAR",0.435333935747911,0.290730039024169,FALSE
+"H460","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.19571,-0.676,0.924,10525,0.983,"CACNB1, CACNG8, MYL3, CACNG1, ACTC1, CACNA2D2, ADCY2, TNNI3, IGF1, MYL2, SGCG, CACNG6, SGCA, DAG1, SGCD, ITGB8, CACNG7, ITGA11, TNF, LAMA2, ITGA9, ADCY4, ITGB7, CACNA2D4, ADCY5, TNNT2, ITGA10, ITGA1, TPM4, CACNA1D, CACNB4, ITGA4, ITGB1, CACNB3, TNNC1, ITGB6, ITGB3, ITGB4, ITGAV, ITGA7, PRKACA, ITGA2, TPM1, ITGA3, ADCY6",0.0343280287798933,0.00744648216786438,FALSE
+"H460","Input","KEGG_DNA_REPLICATION",0.66538,2.45,0,3867,0.0761,"RNASEH1, POLE3, PRIM1, MCM6, RFC2, POLA1, POLD2, RFC5, RPA4, POLE2, SSBP1, MCM7, MCM4, LIG1, PCNA, DNA2, RFC3, RPA2, POLE, POLD1, FEN1, RNASEH2A, RPA1, MCM5",Inf,1.11861534322943,TRUE
+"H460","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.44443,-1.55,0.0634,12777,0.387,"PIWIL2, NOTCH4, ETV7, ETS1, EGFR, SPIRE1, NOTCH2, SOS1, PIWIL4, KRAS, ETS2, MAPK3, MAPK1, SOS2, ETV6",1.19791074211827,0.412289034981089,FALSE
+"H460","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.25493,0.891,0.522,2218,0.655,"ALDH3A1, GSTM1, GSTM3, GSTO2, MGST1, ALDH3B1, GSTM4, GSTO1, MGST2",0.282329496997738,0.183758700008217,FALSE
+"H460","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.24597,0.892,0.584,2401,0.662,"UCK2, IMPDH1, CES2, HPRT1, IMPDH2, CES1, ITPA",0.233587152887601,0.1791420105603,FALSE
+"H460","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.2311,0.835,0.635,255,0.744,"COL4A6, TNXB, LAMC3, LAMA1, SPP1, COL5A2",0.197226274708024,0.128427064454121,FALSE
+"H460","Input","KEGG_ENDOCYTOSIS",-0.39122,-1.37,0.105,13552,0.412,"GRK4, MDM2, AP2A1, SMAP2, VPS37C, PLD2, KIT, IL2RG, PDGFRA, USP8, SH3GL3, CSF1R, EGFR, PRKCZ, ARRB1, GRK3, DNM3, ACAP1, STAM, SH3GL1, DNM1, STAM2, ARAP2, CHMP2A, EPN3, AGAP2, VPS36, CHMP3, CBLC, CXCR4, RAB11B, VTA1, CLTCL1, SH3GLB2, VPS4B, AP2A2, SMURF1, RAB11FIP1, RAB11FIP4, PIP5K1C, FGFR2, F2R, NEDD4L, SMAP1, ASAP1, PDCD6IP, RAB11A, DNM1L, ADRB2, PARD6A, AP2M1, CHMP5, TSG101, ARF6, GRK5, CBLB, CDC42, CHMP2B, ARFGAP3, ERBB3, ACAP2, PSD4, CBL, DAB2, PARD6B, CHMP4B, DNM2, ARAP1, ITCH, VPS37B, EHD2, TRAF6, RAB22A, ARFGAP2, RAB5A, PRKCI, SH3GLB1, SMURF2, VPS28, EPS15, RAB5B",0.978810700930062,0.385102783966865,FALSE
+"H460","Input","KEGG_ENDOMETRIAL_CANCER",-0.44705,-1.55,0.0545,14135,0.387,"EGFR, PIK3R1, CTNNB1, ERBB2, CCND1, AXIN2, APC2, LEF1, TCF7, SOS1, APC, RAF1, GSK3B, KRAS, PIK3CD, CDH1, PIK3R3, AKT2, NRAS, BRAF, MAPK3, MAPK1, TCF7L1, ILK, SOS2, PIK3CA, FOXO3",1.26360349772336,0.412289034981089,FALSE
+"H460","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.26959,-0.93,0.531,13744,0.727,"PTPRZ1, IGSF5, EGFR, JAM2, NFKBIA, ATP6V1G2, ADAM10, CCL5, ATP6V1B2, MAPK11, F11R, PLCG1, MAPK10, ATP6V1A, HBEGF, MAPK13, ATP6V1E1, JUN, RAC1, ATP6V1C1, RELA, CDC42, MAPK14, MAPK8, ATP6V1H",0.274905478918531,0.138465589140962,FALSE
+"H460","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.39252,-1.35,0.12,16073,0.413,"PLCG1, SOS1, MAPK10, NCK2, SHC2, PTK2, RAF1, BTC, STAT5A, GSK3B, CRKL, KRAS, PIK3CD, PAK6, HBEGF, PAK2, JUN, RPS6KB2, PIK3R3, AKT2, NRAS, BRAF, MAPK3, CBLB, MAPK1, ERBB3, TGFA, CBL, GAB1, MAPK8, SOS2, PIK3CA, CDKN1B",0.920818753952375,0.384049948343599,FALSE
+"H460","Input","KEGG_ETHER_LIPID_METABOLISM",0.23702,0.842,0.635,1308,0.738,"PLA2G7, PLA2G4A, CHPT1",0.197226274708024,0.131943638176958,FALSE
+"H460","Input","KEGG_FATTY_ACID_METABOLISM",0.30319,1.09,0.282,2664,0.428,"ALDH9A1, HADH, ECHS1, ALDH3A2, ACADSB, ALDH1B1, HADHA, ACAT1, ACAA2, ECI2, ACADS",0.549750891680639,0.368556230986828,FALSE
+"H460","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.39513,-1.37,0.117,15701,0.412,"SYK, MAPK11, PLCG1, SOS1, MAPK10, PRKCE, RAF1, KRAS, PIK3CD, MAPK13, PIK3R3, RAC1, AKT2, NRAS, RAC2, MAPK3, MAPK1, MAPK14, PLA2G6, GAB2, MAPK8, SOS2, FYN, PIK3CA",0.931814138253838,0.385102783966865,FALSE
+"H460","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.41854,-1.46,0.0808,13117,0.377,"LIMK2, PLA2G4F, WASL, AMPH, FCGR1A, VAV3, DOCK2, ARPC3, LAT, PIK3CB, VAV1, PLD2, SPHK1, PRKCD, PRKCG, PIK3R1, DNM3, SPHK2, DNM1, SYK, VASP, PLCG1, PLPP3, PIP5K1C, PRKCE, RAF1, ASAP1, DNM1L, CRKL, PIK3CD, CFL1, ARF6, RPS6KB2, PIK3R3, RAC1, AKT2, RAC2, MAPK3, MARCKSL1, MAPK1, CDC42, WASF2, PLA2G6, DNM2, GAB2, GSN, MARCKS, PIK3CA",1.09258863922541,0.423658649794207,FALSE
+"H460","Input","KEGG_FOCAL_ADHESION",-0.30502,-1.06,0.354,13444,0.617,"VAV3, XIAP, ROCK2, THBS4, PGF, VWF, ACTN4, PIK3CB, VAV1, ITGB7, PDGFRA, PRKCG, COL5A1, LAMB3, THBS2, EGFR, PDGFA, PIK3R1, CTNNB1, ERBB2, CCND2, CCND1, ITGA10, ITGA1, PXN, LAMA3, MYLPF, CHAD, MYLK2, COL1A2, PAK4, PDGFC, ITGA4, RASGRF1, PPP1CA, PDGFD, ITGB1, VASP, COL11A2, SOS1, MYL9, ITGB6, ITGB3, LAMC2, PIP5K1C, MAPK10, COL6A2, SHC2, ITGB4, PTK2, FLNC, RAF1, ITGAV, ITGA7, LAMA4, MYL12A, GSK3B, CRKL, MYL12B, PIK3CD, BIRC3, PAK6, PARVA, PAK2, JUN, PIK3R3, RAC1, PPP1CB, ITGA2, AKT2, BRAF, ROCK1, RAC2, ARHGAP35, MAPK3, BIRC2, MAPK1, CDC42, VEGFA, TNC, PDGFB, ILK, ARHGAP5, MYLK, RAP1A, ITGA3, VEGFB, MAPK8, THBS1, TLN2, SOS2, BCAR1, FYN, PIK3CA",0.450996737974212,0.209714835966758,FALSE
+"H460","Input","KEGG_FOLATE_BIOSYNTHESIS",0.39893,1.4,0.123,3512,0.256,"SPR, QDPR, PTS, DHFR",0.910094888560602,0.59176003468815,FALSE
+"H460","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.40984,1.52,0.0712,4560,0.21,"AKR1B10, SORD, ALDOA, PFKM, PMM2, PFKP, PHPT1, KHK, AKR1B1, PFKL, ALDOC, HK1, HK2, MTMR2, TPI1, GMPPB, GMDS",1.14752000636314,0.677780705266081,FALSE
+"H460","Input","KEGG_GALACTOSE_METABOLISM",0.3813,1.35,0.115,3880,0.289,"GLA, PFKM, GALK2, PFKP, G6PC2, AKR1B1, PFKL, PGM2, HK1, B4GALT2, HK2",0.939302159646388,0.539102157243452,FALSE
+"H460","Input","KEGG_GAP_JUNCTION",0.18685,0.679,0.926,2889,0.936,"TUBB4A, EGF, ADCY7, SRC, TUBA1B, PLCB1, TUBB3, ITPR1, TUBA1A, ADCY3, PRKX, TUBA4A, CDK1, TUBAL3, GJA1, PRKCB, TUBB4B, TUBA1C",0.0333890133180656,0.0287241512618947,FALSE
+"H460","Input","KEGG_GLIOMA",-0.33716,-1.16,0.25,13607,0.527,"MDM2, PIK3CB, E2F3, PDGFRA, PRKCG, EGFR, PDGFA, PIK3R1, CCND1, CALML6, PLCG1, SOS1, CALM3, SHC2, RAF1, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, PDGFB, TGFA, SOS2, PIK3CA",0.602059991327962,0.278189384787453,FALSE
+"H460","Input","KEGG_GLUTATHIONE_METABOLISM",0.53525,1.91,0.0224,2592,0.0995,"G6PD, GSTM1, PGD, GSR, ODC1, GGT1, GPX3, GCLM, GCLC, GSTM3, GSTO2, RRM2, SRM, LAP3, IDH1, MGST1, GSTM4, GSTO1, MGST2, GGCT, GSTM2",1.64975198166584,1.00217691925427,TRUE
+"H460","Input","KEGG_GLYCEROLIPID_METABOLISM",0.27647,0.982,0.415,1938,0.563,"GLA, DGKD, DGKG, ALDH9A1, GPAT3, ALDH3A2, ALDH1B1, AGK",0.381951903287907,0.249491605148654,FALSE
+"H460","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.237,-0.828,0.673,17294,0.823,"DGKA, CDS1, ETNK1, LPCAT2, MBOAT2, CDS2, DGKH, PLA2G6, CHKA, ETNK2, CHKB",0.171984935776023,0.0846001647877302,FALSE
+"H460","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.22591,-0.801,0.747,13271,0.845,"GCAT, MAOB, PIPOX, DMGDH, SRR, SARDH, GNMT, AMT, GATM, PSPH",0.126679398184601,0.0731432910503077,FALSE
+"H460","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.44645,1.62,0.0442,3658,0.185,"ALDH3A1, PDHA1, ALDH9A1, ALDOA, PFKM, PGAM1, DLD, GPI, ENO1, DLAT, ALDH3A2, PGK1, GAPDH, ALDH3B1, ALDH1B1, LDHA, PFKP, G6PC2, PGAM4, LDHB, PDHB, PKM, PFKL, ALDOC, PGM2, HK1",1.35457773065091,0.732828271596986,TRUE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.34649,1.24,0.178,1325,0.334,"CHSY3, CSGALNACT1, XYLT1, CHST15",0.749579997691106,0.476253533188435,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34926,1.24,0.183,1267,0.334,"GLCE, HS6ST2, XYLT1, HS3ST3B1, HS3ST3A1",0.737548910269571,0.476253533188435,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.40258,-1.42,0.0952,15626,0.381,"B3GNT7, CHST2, FUT8, ST3GAL3, B4GALT4, B3GNT2",1.02136305161553,0.419075024324381,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.26732,0.959,0.456,1267,0.578,"HYAL1, HS3ST3B1, HS3ST3A1",0.341035157335565,0.238072161579471,FALSE
+"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.30879,1.09,0.276,965,0.428,"ST6GALNAC4, B4GALNT1, ST3GAL1",0.559090917934782,0.368556230986828,FALSE
+"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.33252,1.2,0.205,965,0.334,"GLA, ST3GAL1",0.688246138944246,0.476253533188435,FALSE
+"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.41974,-1.46,0.0672,10585,0.377,"FUT5, FUT9, B4GAT1, FUT6, B3GALT2, B4GALT1, FUT4, B3GALT1, B3GNT4, ABO, FUT2, B3GNT5, FUT3, B3GALT5, ST8SIA1, B3GNT3, FUT1, ST3GAL6, ST3GAL3, B4GALT4, B3GNT2",1.17263072694617,0.423658649794207,FALSE
+"H460","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.13232,0.472,1,3367,0.999,"PIGF, PIGB, DPM2, PIGH, PIGO, PIGW",0,0.000434511774017692,FALSE
+"H460","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.59993,2.14,0.00583,2690,0.079,"MTHFD2L, CS, MTHFD1, PGP, MDH2, AFMID, MTHFD2, ACO2",2.23433144524099,1.10237290870956,TRUE
+"H460","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31803,-1.1,0.304,14994,0.609,"PLA2G12A, LHB, CACNA1D, GNRH1, MAP3K3, MAPK11, CALML6, GNRHR, SOS1, CALM3, MAPK10, RAF1, MAP3K4, KRAS, ITPR2, HBEGF, MAPK13, MMP2, JUN, PRKACA, MAP3K2, NRAS, MAPK3, MAPK1, CDC42, MAPK14, PLA2G6, MAPK8, ADCY6, SOS2, MAP3K1, MMP14",0.517126416391246,0.215382707367125,FALSE
+"H460","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.34229,1.19,0.21,12576,0.333,"IL6, IL1A, FAS, CD86, CD80, PRF1, IFNG, KIR2DL1, KIR3DL2, IL2, CD28, KIR3DL1, KIR2DL3, GZMB, FASLG, KLRC1, KLRD1, IL1B, TNF",0.677780705266081,0.47755576649368,FALSE
+"H460","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30046,-1.04,0.377,12943,0.603,"WNT8B, WNT6, WNT16, PTCH1, PTCH2, HHIP, WNT7A, WNT5B, WNT4, BMP8A, CSNK1G2, FBXW11, STK36, WNT2B, WNT10A, BMP7, CSNK1G1, SUFU, CSNK1A1, GSK3B, RAB23, WNT9A, PRKACA, BMP4, CSNK1E, WNT7B",0.423658649794207,0.219682687859849,FALSE
+"H460","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.26207,-0.917,0.518,11009,0.722,"CD19, GP5, CD3D, CD1D, CD33, CD38, CD7, IL11RA, CD36, CD44, THPO, CD34, IL1B, TNF, CD4, ITGAM, CD8A, IL1R2, GP1BA, FCGR1A, KIT, IL3RA, CSF1R, CSF2, ITGA1, ITGA4, CD9, ANPEP, CD22, IL7, IL7R, ITGB3, EPOR, IL11, MME, ITGA2, IL4R, CD59, FLT3LG, ITGA3",0.285670240254767,0.141462802430361,FALSE
+"H460","Input","KEGG_HISTIDINE_METABOLISM",0.45304,1.6,0.059,1779,0.191,"ALDH3A1, BUD23, ALDH9A1, AMDHD1, ALDH3A2, ALDH3B1, ALDH1B1",1.22914798835786,0.718966632752272,FALSE
+"H460","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.4106,1.49,0.0867,3688,0.212,"XRCC3, RAD51D, POLD2, RAD51B, RPA4, SSBP1, XRCC2, RAD51C, RPA2, POLD1, EME1, SEM1, RPA1",1.06198090252379,0.673664139071249,FALSE
+"H460","Input","KEGG_HUNTINGTONS_DISEASE",0.40269,1.41,0.0976,3200,0.253,"ATP5F1B, NDUFB10, SLC25A6, CASP9, NDUFS2, ATP5MC1, VDAC1, UQCRC2, SLC25A5, ATP5MC3, POLR2C, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, POLR2D, VDAC2, NDUFB8, COX7C, SOD1, NDUFA5, POLR2L, NDUFA1, PLCB1, COX5A, PPID, TFAM, COX7B, POLR2J3, ITPR1, NDUFB3, UQCRQ, POLR2I, NDUFB1, COX5B, CASP8, NDUFS6, BDNF, SDHC, ATP5F1A, CREB1, UQCRHL, AP2B1, SDHB, ATP5F1C, NDUFS7, POLR2A, DNAL1, NDUFV3, ATP5MC2, ATP5F1D, NDUFS4, VDAC3, NDUFA7, NDUFC1, POLR2E, COX6A1, COX6B1, UQCRH, CYCS, SDHD, NDUFS5",1.01055018233331,0.596879478824182,FALSE
+"H460","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.20689,-0.711,0.859,10525,0.96,"CACNB1, CACNG8, MYL3, CACNG1, ACTC1, CACNA2D2, TNNI3, IGF1, MYL2, SGCG, CACNG6, SGCA, DAG1, SGCD, ITGB8, CACNG7, ITGA11, TNF, LAMA2, ITGA9, ITGB7, CACNA2D4, TNNT2, ITGA10, ITGA1, TPM4, CACNA1D, CACNB4, ITGA4, ACE, ITGB1, PRKAA1, CACNB3, TNNC1, ITGB6, ITGB3, ITGB4, PRKAB1, ITGAV, ITGA7, ITGA2, TPM1, ITGA3",0.0660068361687577,0.0177287669604316,FALSE
+"H460","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.38151,-1.3,0.156,16073,0.407,"PLCG1, PIP5K1C, PIP4K2A, INPP1, PIK3CD, INPPL1, INPP4B, INPP5J, SYNJ2, SYNJ1, ALDH6A1, PIK3C2A, PLCD1, INPP5B, ISYNA1, PIK3CA",0.806875401645538,0.39040559077478,FALSE
+"H460","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.28842,-0.994,0.423,15520,0.654,"PPP1CA, INPP5K, CBLC, CALML6, PRKAA1, PTPRF, SOS1, TSC1, CALM3, MAPK10, SHC2, PRKAB1, RAF1, GSK3B, CRKL, SOCS1, KRAS, PIK3CD, LIPE, RPS6KB2, PIK3R3, PPP1CB, PRKACA, SORBS1, AKT2, NRAS, BRAF, MAPK3, CBLB, INSR, MKNK1, MAPK1, PTPN1, CBL, MAPK8, SOS2, PRKCI, PHKG1, PIK3CA",0.373659632624958,0.184422251675733,FALSE
+"H460","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.1641,-0.576,0.994,13425,0.997,"TNFSF13, CXCL12, ITGB7, MADCAM1, ITGA4, CXCR4, CCL28",0.00261361560268669,0.00130484168834428,FALSE
+"H460","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.30244,-1.07,0.308,13730,0.661,"PIK3CB, IL13, IL2RG, SPRED1, IL3RA, PIK3R1, CLCF1, CCND2, SPRED2, IL20RA, CSF2, CCND1, JAK2, IL20RB, STAM, CISH, STAM2, CBLC, IL23A, PIAS2, IFNAR2, TYK2, JAK1, IL7, IL7R, SPRY2, SOS1, IL10RB, EPOR, STAT5A, PIM1, SOCS5, IL11, SOCS1, PIK3CD, PIK3R3, IL6ST, AKT2, EP300, PIAS1, IFNGR2, CBLB, SPRY1, CREBBP, IFNGR1, IL4R, CBL, BCL2L1, SOS2, STAT3, IRF9, STAT2, PIK3CA",0.511449283499556,0.17979854051436,FALSE
+"H460","Input","KEGG_LEISHMANIA_INFECTION",-0.4185,-1.46,0.0731,14672,0.377,"JAK2, NCF2, TLR2, TLR4, ITGA4, MAPK11, ITGB1, IRAK4, ITGB2, JAK1, MAPK13, JUN, RELA, MAP3K7, IFNGR2, MAPK3, MARCKSL1, MAPK1, IFNGR1, MAPK14, TRAF6, TAB2",1.13608262304214,0.423658649794207,FALSE
+"H460","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.39162,-1.36,0.111,12132,0.413,"NCF1, PIK3R2, CLDN14, VAV2, PECAM1, CDH5, CLDN7, VCAM1, CLDN23, CLDN10, CLDN3, ITGAM, MMP9, CYBB, VAV3, ROCK2, CXCL12, ACTN4, PIK3CB, VAV1, PRKCG, JAM2, PIK3R1, CTNNB1, NCF2, PXN, CLDN9, MYLPF, THY1, ITGA4, CXCR4, MAPK11, ITGB1, ITGB2, F11R, VASP, PLCG1, MYL9, ESAM, SIPA1, PTK2, GNAI3, MYL12A, AFDN, MYL12B, PIK3CD, MAPK13, MMP2, PIK3R3, RAC1, RASSF5, ROCK1, RAC2, ARHGAP35, CTNND1, CDC42, ICAM1, MAPK14, ARHGAP5, RAP1A, OCLN, BCAR1, PIK3CA",0.954677021213343,0.384049948343599,FALSE
+"H460","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.70752,2.48,0.0029,1898,0.102,"ALDH9A1, ECHS1, ALDH3A2, ALDH1B1, HADHA",2.53760200210104,0.991399828238082,TRUE
+"H460","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.31205,1.21,0.185,292,0.335,"AKR1B10, PLA2G4A",0.732828271596986,0.474955192963155,FALSE
+"H460","Input","KEGG_LONG_TERM_DEPRESSION",-0.20412,-0.702,0.867,14374,0.962,"GNAO1, CACNA1A, GNAQ, GNA13, PLA2G12A, PPP2CB, RAF1, GNAI3, PPP2R1A, KRAS, ITPR2, NRAS, BRAF, MAPK3, MAPK1, PLA2G6",0.0619809025237897,0.0168249279621871,FALSE
+"H460","Input","KEGG_LONG_TERM_POTENTIATION",-0.31608,-1.12,0.274,16365,0.595,"CALM3, RAF1, PPP3CB, KRAS, ITPR2, PPP3CA, PPP1CB, PRKACA, NRAS, BRAF, EP300, MAPK3, RPS6KA2, MAPK1, CREBBP, RAP1A",0.562249437179612,0.22548303427145,FALSE
+"H460","Input","KEGG_LYSINE_DEGRADATION",0.34846,1.26,0.194,3207,0.333,"ALDH9A1, SUV39H1, SETD7, AADAT, DLST, HADH, ECHS1, ALDH3A2, ALDH1B1, HADHA, ACAT1, OGDH, PLOD3, KMT5A, ASH1L, TMLHE",0.712198270069774,0.47755576649368,FALSE
+"H460","Input","KEGG_LYSOSOME",-0.30037,-1.04,0.384,13756,0.603,"AP1S2, PLA2G15, AP3D1, M6PR, LAMP1, DNASE2, CTSA, MCOLN1, CTSK, LAPTM4A, IDUA, NPC1, ACP5, AP3M2, LAPTM5, LAMP2, LAMP3, GNPTG, CLTCL1, CTSO, HEXA, SUMF1, SCARB2, FUCA1, SMPD1, GLB1, SLC17A5, AP1G1, PSAP, AP3S1, ARSA, ACP2, HGSNAT, ENTPD4, CTSB, CTSS, CTSV, MAN2B1, MANBA, MFSD8, NEU1, ATP6V1H, NPC2, CTSH, CD164, SORT1, TPP1",0.415668775632469,0.219682687859849,FALSE
+"H460","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.29299,-1.01,0.406,15225,0.642,"MAP3K11, RASA1, CACNA1D, CACNB4, RASGRP3, RASGRF1, HSPB1, MAP3K3, STK3, MAPK8IP2, FGF1, MAPK11, CACNB3, TAOK1, RRAS, SOS1, DUSP16, FGFR2, MAPK10, GADD45A, NTF4, ATF2, FLNC, RAF1, PTPRR, PPP3CB, MAP3K4, CRKL, MAP3K6, KRAS, PAK2, MAPK13, DUSP8, JUN, PPP3CA, DDIT3, RAC1, PRKACA, FGF11, MAP3K2, AKT2, NRAS, RELA, BRAF, MAP3K7, RAC2, MAPK3, PPM1A, RPS6KA2, MKNK1, MAPK1, CDC42, STMN1, MRAS, MAPKAPK2, NLK, MAPK14, PDGFB, MAPK8IP1, SRF, PLA2G6, MECOM, RAP1A, RASA2, MAPK8, TGFBR2, DUSP10, TRAF6, LAMTOR3, SOS2, MAP4K3, RELB, MAP3K1, PPM1B, TAB2",0.391473966422806,0.192464971931147,FALSE
+"H460","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.21355,-0.739,0.83,11298,0.939,"PDX1, HNF1A, HNF4A, MAFA, GCK, FOXA3, HNF1B, NR5A2, FOXA2, HES1",0.0809219076239261,0.0273344077338891,FALSE
+"H460","Input","KEGG_MELANOGENESIS",-0.26768,-0.933,0.511,12802,0.731,"CAMK2A, CREB3L2, WNT8B, WNT6, WNT16, ADCY4, FZD1, WNT7A, WNT5B, KIT, PRKCG, CREB3L4, CTNNB1, ADCY5, WNT4, GNAO1, GNAQ, CREB3, WNT2B, WNT10A, CALML6, LEF1, TCF7, CALM3, FZD2, CREB3L1, RAF1, FZD6, GNAI3, GSK3B, KRAS, WNT9A, PRKACA, NRAS, EP300, MAPK3, WNT7B, MAPK1, TCF7L1, CREBBP, ADCY6, DVL3",0.291579099865287,0.13608262304214,FALSE
+"H460","Input","KEGG_MELANOMA",-0.27922,-0.965,0.452,11042,0.684,"FGF7, PIK3CG, FGF8, HGF, IGF1, MET, FGF22, AKT3, FGF17, FGF21, MITF, PIK3R2, FGF9, RB1, FGF18, MDM2, PIK3CB, E2F3, PDGFRA, EGFR, PDGFA, PIK3R1, CCND1, FGF5, PDGFC, PDGFD, FGF1, RAF1, KRAS, PIK3CD, CDH1, PIK3R3, FGF11, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, PDGFB, PIK3CA",0.344861565188618,0.164943898279884,FALSE
+"H460","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43887,1.53,0.0806,2218,0.21,"ALDH3A1, GSTM1, AKR1C2, AKR1C1, EPHX1, AKR1C3, CYP1B1, GSTM3, GSTO2, MGST1, ALDH3B1, GSTM4, GSTO1, MGST2",1.09366495819491,0.677780705266081,FALSE
+"H460","Input","KEGG_MISMATCH_REPAIR",0.64874,2.32,0.00296,2985,0.0689,"EXO1, RFC2, POLD2, RFC5, RPA4, SSBP1, LIG1, PCNA, RFC3, RPA2, POLD1",2.52870828894106,1.16178077809237,TRUE
+"H460","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38178,-1.32,0.13,15817,0.389,"PRKAA1, TSC1, HIF1A, CAB39L, PIK3CD, RPS6KB2, PIK3R3, AKT2, CAB39, BRAF, MAPK3, RPS6KA2, MAPK1, VEGFA, VEGFB, RICTOR, PIK3CA",0.886056647693163,0.410050398674292,FALSE
+"H460","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.30396,-1.05,0.336,12133,0.614,"PIK3R2, PPP3R2, SH2D1B, VAV2, CHP1, TNF, ULBP2, TNFRSF10D, NFATC2, KLRC3, ULBP1, KLRK1, VAV3, LCK, LAT, PIK3CB, VAV1, KLRC2, PRKCG, PIK3R1, RAET1L, CSF2, ICAM2, HCST, SYK, ITGB2, IFNAR2, PLCG1, SOS1, SHC2, RAF1, PPP3CB, KRAS, PIK3CD, TNFSF10, PIK3R3, PPP3CA, RAC1, NRAS, BRAF, IFNGR2, RAC2, MAPK3, MAPK1, IFNGR1, ICAM1, SH3BP2, SOS2, NFAT5, FYN, PIK3CA",0.473660722610156,0.211831628858832,FALSE
+"H460","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.13822,-0.48,1,8151,0.999,"NPY2R, GABRG1, TAAR1, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CRHR2, PRL, GPR83, P2RY10, P2RY4, HTR4, GABRB3, HCRTR1, APLNR, GRM1, P2RX3, TSHB, ADRA1A, HCRTR2, CCKAR, GABRA4, GLP1R, GPR50, CALCR, S1PR4, HTR2B, RXFP1, TRHR, HRH3, NR3C1, CHRNA4, MC5R, DRD5, CHRNB2, CCKBR, FPR2, HTR1F, AVPR1A, FPR3, GABRB2, GRM7, P2RX7, AVPR1B, TACR3, THRA, HTR2A, NPY5R, GRM5, NMUR2, F2, P2RY8, ADCYAP1R1, CGA, CHRNB4, PTGER2, CYSLTR1, GRIA1, GABRG3, UTS2R, NPFFR1, CHRM2, GRM3, GRIN2C, P2RX1, LPAR6, GHSR, GRIN2D, P2RY13, GABRA2, GHRHR, GABRR1, SSTR2, GABRD, F2RL3, CHRNA1, CHRM1, GABRB1, GRIK3, CRHR1, ADORA3, PTGER3, GABRA5, PRSS1, GRIA3, MCHR2, CHRNA9, CHRNA3, CALCRL, MCHR1, PTGER1, GRM2, GRM8, P2RX2, GRIA2, EDNRB, GRID2, DRD1, CTSG, GRM4, HRH2, GRIA4, PRSS2, PTGIR, KISS1R, PLG, LPAR4, AGTR1, OPRD1, GRIN2A, GABRP, GRIN2B, SSTR1, P2RY14, PTH2R, ADRA2B, LPAR3, NPY1R, CNR1, DRD2, NPFFR2, ADRA2A, GABRG2, NPBWR1, TRPV1, FPR1, GRIK5, GRID1, HTR2C, PTGER4, OXTR, GALR3, PRLR, NMBR, GRIK4, GRIN1, GABRQ, HRH1, P2RY6, PTGFR, EDNRA, NPY4R, GRPR, GRIN3B, C3AR1, GPR156, ADRA1B, CHRNA10, CHRNE, GPR35, TACR2, CHRM4, GABRR2, LHB, GRIK2, GIPR, PRSS3, PTAFR, BDKRB1, S1PR1, HTR7, CHRM3, OPRL1, DRD4, GABRA3, P2RY2, GNRHR, ADORA2B, F2R, BDKRB2, VIPR1, P2RX4, ADORA2A, ADRB2, ADORA1, THRB, LPAR1, CHRNB1, P2RY11, F2RL1, S1PR2, LPAR2",0,0.000434511774017692,FALSE
+"H460","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.40897,-1.43,0.0716,15435,0.385,"NGFR, MAP3K3, MAPK11, IRAK4, CALML6, PSEN1, PLCG1, SOS1, CALM3, MAPK10, FRS2, SHC2, NTF4, RAF1, GSK3B, CRKL, KRAS, PIK3CD, MAPK13, JUN, TP73, PIK3R3, RAC1, AKT2, NRAS, RELA, BRAF, NFKBIE, MAPK3, RPS6KA2, MAPK1, CDC42, MAPKAPK2, MAPK14, GAB1, ARHGDIB, RAP1A, MAPK8, TRAF6, YWHAZ, SOS2, MAP3K1, PIK3CA, SORT1, FOXO3",1.14508697769214,0.414539270491499,FALSE
+"H460","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.35394,1.27,0.178,1786,0.329,"NAMPT, PNP, NT5M, NT5C, BST1",0.749579997691106,0.482804102050026,FALSE
+"H460","Input","KEGG_NITROGEN_METABOLISM",0.29713,1.07,0.307,887,0.443,"CPS1, CA12",0.512861624522813,0.35359627377693,FALSE
+"H460","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.30548,-1.06,0.327,16420,0.617,"MAPK10, TAB3, BIRC3, MAPK13, CASP1, RELA, MAP3K7, PYCARD, MAPK3, BIRC2, MAPK1, NLRP1, ERBIN, MAPK14, MAPK8, TRAF6, TAB2",0.485452247339714,0.209714835966758,FALSE
+"H460","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.36945,-1.26,0.167,16071,0.423,"MRE11, LIG4, POLM, DCLRE1C",0.777283528852417,0.373659632624958,FALSE
+"H460","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.4574,-1.59,0.0434,16073,0.437,"PLCG1, SOS1, FHIT, RAF1, KRAS, PIK3CD, PIK3R3, RASSF5, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, TGFA, SOS2, RXRB, PIK3CA, FOXO3",1.36251027048749,0.359518563029578,FALSE
+"H460","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.4997,-1.75,0.0103,15409,0.375,"MAML2, NOTCH2, DLL1, RBPJ, MFNG, PSEN1, NUMB, KAT2B, DTX3L, DTX4, EP300, JAG1, MAML1, CREBBP, LFNG, RFNG, DVL3, HES1, CIR1, HDAC1, DTX2",1.98716277529483,0.425968732272281,FALSE
+"H460","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.39236,1.41,0.104,3841,0.253,"GTF2H2, POLE3, RFC2, CUL4A, POLD2, RFC5, RPA4, POLE2, CCNH, ERCC8, LIG1, PCNA, RFC3, CDK7, RPA2, POLE, POLD1, XPA, GTF2H3, ERCC3, RAD23B, RPA1, XPC",0.98296666070122,0.596879478824182,FALSE
+"H460","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.23208,-0.802,0.763,15016,0.854,"MAN2A2, ALG2, ALG8, MAN1C1, MGAT3, ALG6, ALG11, FUT8, DDOST, MGAT5B, MGAT4A, MAN1A1, MAN1A2",0.11747546204512,0.068542129310995,FALSE
+"H460","Input","KEGG_OLFACTORY_TRANSDUCTION",0.2195,0.813,0.752,11747,0.77,"PDE1C, CALM1, ARRB2, ADCY3, PRKX, OR6A2, OR10AD1, OR10A2, GNAL, CAMK2D, OR1F1, CALM2, OR1L8, OR2AT4, PRKG2, OR2AG1, OR7C1, PRKACB, OR1Q1, OR6C6, OR52J3, OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR52D1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR13J1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR2AE1, OR5AK2, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2H2, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR7D2, OR1B1, OR2L3, OR8D1, OR51E2, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, OR13D1, OR8D2, OR2T33, OR1J2, OR2S2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, CALML3, OR4D1, OR2C1, OR8G1, CALML5, OR4F15, OR52B6, OR2A25, OR2D3, OR10H1, OR8A1, OR2B2, OR1K1, OR56B4, OR2J3, OR10A6, OR2A2, OR1J1, OR8G5, OR4F3, OR11H4, OR10A4, GUCY2D, OR51B4, OR13A1, OR6B2, OR2A12, OR2D2, OR10A3, OR2K2, PRKG1, CNGB1, OR13H1, OR2A14",0.123782159408358,0.113509274827518,FALSE
+"H460","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.50003,1.78,0.0329,3512,0.126,"MTHFD2L, MTFMT, ATIC, MTHFD1, SHMT2, SHMT1, MTHFD2, MTHFS, MTR, DHFR",1.48280410205003,0.899629454882437,TRUE
+"H460","Input","KEGG_OOCYTE_MEIOSIS",0.22185,0.804,0.722,2884,0.779,"YWHAE, ADCY7, ANAPC1, ANAPC5, CALM1, AR, ANAPC7, MAPK12, SMC1A, ITPR1, YWHAG, PTTG1, AURKA, ADCY3, PLK1, PRKX, CDC26, CCNB1, BUB1, PKMYT1, CUL1, CDK1, PPP2R5C, PPP2R1B, PPP2CA, PPP1CC, CAMK2D, SLK, SMC3",0.141462802430361,0.108462542327436,FALSE
+"H460","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.55136,-1.92,0.00574,15891,0.4,"HEXA, FUCA1, GLB1, MAN2B2, MAN2B1, MANBA, NEU1",2.24108810760203,0.397940008672038,FALSE
+"H460","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.46153,1.63,0.054,3200,0.187,"ATP5F1B, NDUFB10, NDUFS2, ATP5MC1, COX10, UQCRC2, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, COX15, ATP5ME, NDUFB8, COX7C, COX11, PPA1, NDUFA5, NDUFA1, COX5A, COX7B, NDUFB3, UQCRQ, NDUFB1, COX5B, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, NDUFS7, NDUFV3, ATP6V0D1, ATP5MC2, ATP5F1D, NDUFS4, ATP6V0E2, NDUFA7, NDUFC1, COX6A1, COX6B1, ATP6AP1, UQCRH, PPA2, SDHD, NDUFS5",1.26760624017703,0.728158393463501,FALSE
+"H460","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.3466,1.2,0.231,1859,0.334,"GALNT16, GALNT13, GALNT14, ST3GAL1, C1GALT1C1, GALNT18, GALNT11",0.636388020107856,0.476253533188435,FALSE
+"H460","Input","KEGG_P53_SIGNALING_PATHWAY",-0.25547,-0.88,0.592,13371,0.781,"ADGRB1, GADD45B, MDM2, CCNE2, DDB2, PMAIP1, CCND2, CCNE1, CCND1, SESN1, RRM2B, BBC3, SERPINE1, ATM, GADD45A, ZMAT3, APAF1, TP73, SESN2, CDKN2A, THBS1, SIAH1, CD82, CCNG2",0.22767829327708,0.1073489661227,FALSE
+"H460","Input","KEGG_PANCREATIC_CANCER",-0.44057,-1.51,0.0665,16420,0.392,"MAPK10, RAF1, KRAS, PIK3CD, RALB, PIK3R3, RAC1, AKT2, RELA, BRAF, RAC2, MAPK3, MAPK1, CDKN2A, CDC42, VEGFA, SMAD3, TGFA, RALA, BCL2L1, VEGFB, MAPK8, TGFBR2, STAT3, PIK3CA",1.1771783546969,0.406713932979543,FALSE
+"H460","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.38375,-1.32,0.134,10754,0.389,"DPYS, ENPP1, ENPP3, UPB1, VNN2, VNN1, PANK4, PANK3, PPCS, DPYD",0.872895201635192,0.410050398674292,FALSE
+"H460","Input","KEGG_PARKINSONS_DISEASE",0.55018,1.99,0.00619,3200,0.0918,"PRKN, ATP5F1B, NDUFB10, SLC25A6, SNCA, CASP9, NDUFS2, ATP5MC1, VDAC1, UQCRC2, SLC25A5, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, UCHL1, VDAC2, NDUFB8, COX7C, NDUFA5, NDUFA1, COX5A, PPID, COX7B, NDUFB3, UQCRQ, NDUFB1, COX5B, HTRA2, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, NDUFS7, NDUFV3, UBB, ATP5MC2, ATP5F1D, NDUFS4, UBA1, VDAC3, NDUFA7, NDUFC1, COX6A1, COX6B1, PARK7, UQCRH, CYCS, SDHD, NDUFS5",2.20830935097988,1.03715731879876,TRUE
+"H460","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.25758,0.921,0.471,4082,0.631,"NCL, ARHGEF2, TUBB4A, HCLS1, TUBA1B, CD14, TUBB3, TUBA1A, ARPC5L, TUBA4A, RHOA, TUBAL3, TUBB4B, TUBA1C, TUBB2B, EZR, TUBB2A, KRT18, ACTG1, ACTB, TUBA3D, TUBB6, ABL1",0.326979092871104,0.199970640755866,FALSE
+"H460","Input","KEGG_PATHWAYS_IN_CANCER",-0.29691,-1.03,0.404,16043,0.612,"JAK1, FADD, PLCG1, LEF1, TCF7, SOS1, LAMC2, HIF1A, DAPK2, FGFR2, DAPK3, RARA, FZD2, MAPK10, NCOA4, PTK2, SUFU, RUNX1, ELOC, RBX1, APC, RAF1, ITGAV, FZD6, STAT5A, ARNT2, LAMA4, GSK3B, CRKL, KRAS, PIK3CD, BIRC3, CDH1, MMP2, WNT9A, CUL2, RALB, JUN, PIK3R3, CDKN2B, RAC1, RASSF5, FGF11, ITGA2, AKT2, NRAS, RELA, BRAF, BMP4, EP300, PIAS1, RAC2, MAPK3, BIRC2, CBLB, WNT7B, MAPK1, CDKN2A, CDC42, TCF7L1, CREBBP, DAPK1, VEGFA, EGLN2, SMAD3, PDGFB, TGFA, CBL, MECOM, RALA, FLT3LG, BCL2L1, ITGA3, VEGFB, MAPK8, TGFBR2, TRAF6, SOS2, DVL3, PPARD, HDAC1, STAT3, RXRB, PIK3CA, CDKN1B",0.393618634889395,0.213248577854439,FALSE
+"H460","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.35682,1.28,0.142,1865,0.332,"UGDH, RPE, DCXR",0.847711655616944,0.478861916295964,FALSE
+"H460","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.5638,2.03,0.0092,2290,0.109,"G6PD, PGD, TKT, PRPS1, TALDO1, ALDOA, PFKM, PRPS2, GPI, RPE, PFKP, RPIA",2.03621217265444,0.962573502059376,TRUE
+"H460","Input","KEGG_PEROXISOME",-0.30624,-1.06,0.347,16111,0.617,"ACOX1, PEX7, XDH, PAOX, ACSL5, IDH2, PRDX5, PEX11G, PEX5, MLYCD, FAR2, ACOX3, ACOT8, PEX2, HMGCL, SCP2, CAT",0.459670525209126,0.209714835966758,FALSE
+"H460","Input","KEGG_PHENYLALANINE_METABOLISM",0.56433,2.02,0.0132,1596,0.0963,"ALDH3A1, GOT2, HPD, PRDX6, AOC3, ALDH3B1",1.87942606879415,1.01637371287547,TRUE
+"H460","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.31731,-1.1,0.295,15535,0.609,"INPP5K, CALML6, PLCG1, PIP5K1C, CALM3, PIP4K2A, INPP1, PIK3CD, ITPR2, PIK3R3, DGKA, INPPL1, INPP4B, INPP5J, CDS1, SYNJ2, SYNJ1, CDS2, DGKH, PIK3C2A, PLCD1, INPP5B, PIK3CA",0.530177984021837,0.215382707367125,FALSE
+"H460","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.52074,1.87,0.0189,1873,0.108,"COX10, EARS2, HCCS, COX15, MMAB, BLVRB, FECH, BLVRA, UROD",1.72353819582676,0.96657624451305,TRUE
+"H460","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.23813,-0.83,0.674,15730,0.83,"ACAA1, CYP27A1, ACOX1, ACSL5, SLC27A1, SORBS1, PPARA, CPT1B, ILK, ACOX3, SCP2, PPARD, RXRB",0.17134010346468,0.0809219076239261,FALSE
+"H460","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.28596,0.998,0.428,1362,0.541,"SLC27A5, ACOX2, CYP39A1",0.368556230986828,0.266802734893431,FALSE
+"H460","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.18797,-0.652,0.948,10646,0.975,"CD79A, ZAP70, CD19, CD3D, IGLL1, JAK3, CD4, CD8A, CIITA, LCK, RFXAP, BLNK, IL2RG, RAG1, IL7R, RFXANK, DCLRE1C",0.0231916626619338,0.0109953843014632,FALSE
+"H460","Input","KEGG_PRION_DISEASES",0.30639,1.09,0.304,2117,0.428,"SOD1, HSPA5, IL6, LAMC1, NCAM2, HSPA1A, PRKX, STIP1",0.517126416391246,0.368556230986828,FALSE
+"H460","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.27052,0.968,0.467,2295,0.571,"PDE3A, HSP90AA1, PDE3B, HSP90AB1, ADCY7, ANAPC1, ANAPC5, ANAPC7, CDC25A, MAPK12, ARAF, AKT1, ADCY3, PLK1, PRKX, CDC26, CCNB1, BUB1, PKMYT1, CDK1, MAPK9",0.330683119433888,0.243363891754152,FALSE
+"H460","Input","KEGG_PROPANOATE_METABOLISM",0.45661,1.64,0.0531,2859,0.188,"ALDH9A1, ACSS3, SUCLG1, MCEE, ECHS1, ALDH3A2, ALDH1B1, HADHA, LDHA, ACAT1, ACACA, HIBCH, LDHB",1.27490547891853,0.72584215073632,FALSE
+"H460","Input","KEGG_PROSTATE_CANCER",-0.33808,-1.16,0.235,13607,0.527,"MDM2, PIK3CB, E2F3, PDGFRA, CCNE2, CREB3L4, EGFR, NFKBIA, PDGFA, PIK3R1, CTNNB1, ERBB2, CCNE1, CCND1, CREB3, PDGFC, PDGFD, LEF1, TCF7, SOS1, FGFR2, CREB3L1, RAF1, GSK3B, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, RELA, BRAF, EP300, MAPK3, MAPK1, TCF7L1, CREBBP, PDGFB, TGFA, SOS2, PIK3CA, CDKN1B",0.628932137728264,0.278189384787453,FALSE
+"H460","Input","KEGG_PROTEASOME",0.66446,2.4,0.00311,3881,0.0724,"PSMB10, PSMB5, PSMA3, PSMD4, PSMD11, PSMC1, PSME3, PSMD14, PSMB6, PSMD1, PSMA6, PSMA4, PSMC5, PSMB4, POMP, PSMD7, PSMB7, PSMB3, PSMD12, PSMA7, PSMF1, PSMC6, PSMC2, PSMC4, PSMD3, PSMB8, SEM1, PSMB9, PSME2, PSMA1",2.50723961097316,1.14026143380285,TRUE
+"H460","Input","KEGG_PROTEIN_EXPORT",0.21314,0.753,0.791,2667,0.848,"HSPA5, OXA1L, SRP68, SRP19, SPCS1, SEC11A",0.101823516502323,0.0716041477432862,FALSE
+"H460","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23093,-0.817,0.701,8788,0.835,"ATP1A2, ATP1B4, ATP1A4, CA4, MDH1, PCK1, GLS, FXYD2, ATP1B2, SLC38A3, GLUD1, AQP1, GLS2, PCK2, ATP1A1, SLC4A4, GLUD2",0.154281982033341,0.0783135245163979,FALSE
+"H460","Input","KEGG_PURINE_METABOLISM",0.50449,1.82,0.0248,3031,0.121,"PDE1A, PDE3A, GDA, PDE10A, PNPT1, PDE7B, PDE4D, POLR3K, NPR1, PFAS, POLR3G, PAPSS2, POLR2C, PDE3B, PRPS1, POLE3, NME1, ADCY7, IMPDH1, PNP, NT5M, POLR2D, ATIC, PRIM1, PDE4B, NT5C, PDE8B, PDE1C, PRPS2, NME2, POLA1, RRM2, POLR2L, NME4, HPRT1, AK2, POLD2, DGUOK, POLR2J3, POLE2, IMPDH2, ADCY3, POLR3B, NME3, GUK1, POLR2I, POLR1B, ADSL, POLR3D, NUDT9, ENTPD6, POLR1E, PAICS, POLR2A, POLR3GL, ITPA, POLR3A, NME5, PPAT, POLR2E, POLE, POLD1, POLR1A, PDE4A",1.60554831917378,0.91721462968355,TRUE
+"H460","Input","KEGG_PYRIMIDINE_METABOLISM",0.49961,1.79,0.0279,3137,0.127,"UCK2, PNPT1, POLR3K, POLR3G, POLR2C, TXNRD1, DHODH, POLE3, NME1, PNP, NT5M, POLR2D, PRIM1, NT5C, DTYMK, NME2, POLA1, RRM2, CAD, POLR2L, NME4, POLD2, CTPS1, POLR2J3, POLE2, POLR3B, NME3, POLR2I, POLR1B, POLR3D, ENTPD6, POLR1E, POLR2A, POLR3GL, ITPA, POLR3A, NME5, POLR2E, POLE, POLD1, POLR1A, TXNRD2, NT5C3A",1.5543957967264,0.896196279044043,TRUE
+"H460","Input","KEGG_PYRUVATE_METABOLISM",0.53128,1.94,0.0213,3525,0.0943,"PDHA1, ALDH9A1, ME1, HAGHL, DLD, ACYP1, DLAT, ME2, MDH2, ALDH3A2, ALDH1B1, LDHA, ACAT1, ACACA, LDHB, AKR1B1, PDHB, PKM, LDHD, GRHPR",1.67162039656126,1.02548830726267,TRUE
+"H460","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.33182,-1.16,0.246,13444,0.527,"VAV3, ROCK2, ARPC3, IQGAP2, ACTN4, PIK3CB, VAV1, ITGB7, PDGFRA, ITGAX, EGFR, PDGFA, PIK3R1, MYH9, RRAS2, FGF5, CHRM4, ITGA10, ITGA1, PXN, APC2, GNA13, MYLPF, MYLK2, PAK4, PDGFC, BDKRB1, ITGA4, CHRM3, PPP1CA, PDGFD, FGF1, ITGB1, ITGB2, RRAS, SOS1, MYL9, ITGB6, ITGB3, PIP5K1C, FGFR2, PIP4K2A, F2R, BDKRB2, ITGB4, PTK2, TIAM1, APC, SSH2, RAF1, ITGAV, ITGA7, MYL12A, CRKL, MYL12B, KRAS, PIK3CD, PAK6, PAK2, CFL1, BAIAP2, PIK3R3, RAC1, PPP1CB, FGF11, ITGA2, NRAS, BRAF, ROCK1, RAC2, ARHGAP35, MAPK3, ARHGEF7, BRK1, MAPK1, CDC42, MRAS, WASF2, PDGFB, ARHGEF12, MYLK, PFN4, ITGA3, SOS2, BCAR1, GSN, TIAM2, PIK3CA",0.609064892896621,0.278189384787453,FALSE
+"H460","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.18999,-0.653,0.926,15784,0.985,"ATG12, PRKAA1, ATG5, GABARAP, GABARAPL2",0.0333890133180656,0.00656376950238827,FALSE
+"H460","Input","KEGG_RENAL_CELL_CARCINOMA",-0.5016,-1.74,0.0206,16164,0.327,"SOS1, FLCN, HIF1A, ELOC, RBX1, RAF1, ARNT2, CRKL, KRAS, PIK3CD, PAK6, PAK2, CUL2, JUN, PIK3R3, RAC1, AKT2, NRAS, BRAF, EP300, MAPK3, MAPK1, CDC42, CREBBP, VEGFA, EGLN2, PDGFB, TGFA, GAB1, RAP1A, VEGFB, SOS2, PIK3CA",1.68613277963085,0.485452247339714,FALSE
+"H460","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.25803,0.911,0.521,1166,0.642,"NLN, THOP1",0.283162276700476,0.192464971931147,FALSE
+"H460","Input","KEGG_RETINOL_METABOLISM",-0.17394,-0.601,0.982,8288,0.998,"ADH1B, RDH8, UGT2B4, ADH4, UGT2B17, CYP1A2, ADH1A, AWAT2, UGT2A3, CYP2C19, UGT2B15, CYP2A7, CYP2C9, CYP26C1, CYP26B1, CYP2B6, CYP2C18, CYP3A4, ADH1C, CYP4A22, CYP2A6, CYP2C8, LRAT, CYP26A1, ADH6, DHRS9, UGT2B7, RDH5, RDH16, BCO1, RETSAT, RDH12, CYP3A5, ALDH1A2, DGAT2, DHRS3, RDH10, CYP1A1, DGAT1",0.00788851221305034,0.000869458712628891,FALSE
+"H460","Input","KEGG_RIBOFLAVIN_METABOLISM",0.40671,1.49,0.0839,2443,0.212,"RFK, FLAD1, ACP1, PHPT1",1.0762380391713,0.673664139071249,FALSE
+"H460","Input","KEGG_RIBOSOME",0.60489,2.14,0.0151,4206,0.079,"RPS4Y1, RPS4X, RPL31, RPL22L1, RPL36AL, RPS23, RPS26, RPL38, RPL13, RPLP1, RPL23A, RPS2, RPL26L1, RPL3, RPL7A, RPL17, RPLP0, RPS29, RPL36A, RPS9, RPL35, RPS7, RPL27, RPS15A, RPL19, RPL26, RPL9, RPS15, RPS24, RPL14, RPL10, RPS27A, RPL23, RPL13A, RPL39, RPS21, RPS17, RPL4, RPL37A, RPS12, RPS10, RPL6, RPL29, RPL37, RPL36, RPL41, RPS27, RPL10A, RPS25, RPSA, RPL34, RPS27L, RPL12",1.82102305270683,1.10237290870956,TRUE
+"H460","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.30382,-1.06,0.348,15508,0.617,"AZI2, MAPK11, ATG12, IFIH1, TKFC, FADD, MAPK10, ATG5, MAPK13, RELA, IRF7, MAP3K7, MAPK14, ISG15, RIPK1, MAPK8, TRAF6, CYLD, MAP3K1",0.458420756053419,0.209714835966758,FALSE
+"H460","Input","KEGG_RNA_DEGRADATION",0.3458,1.21,0.218,1464,0.335,"HSPD1, PNPT1, HSPA9, EDC4, EXOSC2, MTREX, EXOSC8, ENO1, WDR61, EXOSC7, EXOSC1, CNOT1, EXOSC9",0.661543506395395,0.474955192963155,FALSE
+"H460","Input","KEGG_RNA_POLYMERASE",0.6485,2.29,0.00917,3017,0.0657,"POLR3K, POLR3G, POLR2C, POLR2D, POLR2L, POLR2J3, POLR3B, POLR2I, POLR1B, POLR3D, POLR1E, POLR2A, POLR3GL, POLR3A, POLR2E, POLR1A",2.03763066432998,1.18243463044022,TRUE
+"H460","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.55174,1.94,0.0185,1843,0.0943,"SCLY, BUD23, MARS2, PAPSS2, GGT1, AHCY, AHCYL2, MAT2A",1.73282827159699,1.02548830726267,TRUE
+"H460","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.27722,-0.963,0.484,15761,0.677,"ITGB1, TRAF1, PIAS2, LAMC2, PTK2, FHIT, ITGAV, LAMA4, PIK3CD, BIRC3, APAF1, PIK3R3, CDKN2B, ITGA2, AKT2, RELA, PIAS1, BIRC2, BCL2L1, ITGA3, TRAF6, RXRB, PIK3CA, CDKN1B",0.315154638355588,0.169411331314856,FALSE
+"H460","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.43415,-1.55,0.0422,17822,0.387,"SNAP29, SNAP23, VAMP5, STX7, VAMP3, TSNARE1, BET1, STX3, STX12, STX5",1.37468754903833,0.412289034981089,FALSE
+"H460","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2283,-0.789,0.74,12862,0.858,"DEGS2, ASAH1, SGPP2, GAL3ST1, SPHK1, ACER3, SPHK2, KDSR, SMPD3, CERK, PLPP3, SMPD1, GLB1, SGPL1, ARSA, SPTLC2, UGCG, NEU1",0.130768280269024,0.0665127121512946,FALSE
+"H460","Input","KEGG_SPLICEOSOME",0.43261,1.55,0.0581,3540,0.202,"SNRPF, HNRNPU, HNRNPM, SNRPB, PQBP1, HNRNPA3, PRPF4, HNRNPC, SRSF7, USP39, PRPF8, SNRPE, RBM8A, HSPA1A, HSPA8, HSPA1B, SNRPD3, PCBP1, HNRNPA1, ALYREF, SNRNP200, EIF4A3, SNRPG, SNRPA, SRSF1, CCDC12, PPIH, SRSF2, SRSF3, EFTUD2, SF3B4, U2AF2, SNRNP70, DDX46, ZMAT2, PHF5A, SNRPA1, SNRPD1, CTNNBL1, DDX23, LSM8, LSM6, HSPA6, TXNL4A, TCERG1, NCBP1, RBMX, HNRNPK, THOC3, PRPF6, LSM4, LSM7, PRPF40A, SRSF9, SNRPB2",1.23582386760967,0.694648630553376,FALSE
+"H460","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.21776,0.781,0.735,2120,0.805,"UGDH, PYGB, GPI, PYGL, GBE1",0.133712660915805,0.0942041196321315,FALSE
+"H460","Input","KEGG_STEROID_BIOSYNTHESIS",-0.27849,-0.972,0.458,13959,0.69,"SQLE, CEL, MSMO1, SC5D, DHCR24, TM7SF2",0.339134521996131,0.161150909262745,FALSE
+"H460","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.2603,0.933,0.519,959,0.618,"AKR1C2, AKR1C1, AKR1C3, CYP1B1",0.284832642151542,0.209011524911184,FALSE
+"H460","Input","KEGG_SULFUR_METABOLISM",0.36449,1.31,0.146,1528,0.314,"PAPSS2, SULT1A4, SULT1A1",0.835647144215563,0.503070351926785,FALSE
+"H460","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.1358,0.485,1,1409,1,"SNRPB, SSB, SNRPD3",0,0,FALSE
+"H460","Input","KEGG_TASTE_TRANSDUCTION",-0.20982,-0.72,0.852,13045,0.958,"TAS2R13, ADCY4, GNG3, TAS2R3, KCNB1, TAS2R20, CACNA1A, TAS2R10, GNB1, TAS2R4, TAS2R46, TAS2R31, SCNN1A, TAS2R14, TAS2R19, PRKACA, TAS2R5, ADCY6",0.0695604052332999,0.0186344909214556,FALSE
+"H460","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.37443,-1.27,0.15,12475,0.43,"CDO1, GGT6, GGT5, ADO, CSAD, GGT7, GAD1",0.823908740944319,0.366531544420413,FALSE
+"H460","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.33549,1.21,0.202,4809,0.335,"PMVK, PDSS1, ACAT1, FDPS, MVK, IDI1, ACAT2, GGPS1",0.694648630553376,0.474955192963155,FALSE
+"H460","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.41502,-1.44,0.0852,15342,0.39,"BMP7, INHBE, INHBA, INHBB, PPP2CB, SMURF1, ID4, SP1, BMPR1B, ACVR1, RBX1, PPP2R1A, ACVR2B, RPS6KB2, CDKN2B, BMP4, EP300, ROCK1, RBL2, MAPK3, MAPK1, ACVR2A, CREBBP, SMAD3, LTBP1, THBS1, TGFBR2, ZFYVE9, SMAD7, BMPR2, SMURF2",1.0695604052333,0.408935392973501,FALSE
+"H460","Input","KEGG_THYROID_CANCER",-0.46805,-1.65,0.0416,14209,0.374,"CTNNB1, CCND1, TFG, LEF1, TCF7, NCOA4, KRAS, CDH1, NRAS, BRAF, MAPK3, MAPK1, TCF7L1, RXRB",1.38090666937326,0.42712839779952,FALSE
+"H460","Input","KEGG_TIGHT_JUNCTION",-0.29923,-1.04,0.382,13637,0.603,"MYH7B, ACTN4, MAGI3, EXOC4, IGSF5, PRKCD, PRKCG, YES1, PRKCZ, JAM2, PPP2R2A, CTNNB1, MYH9, MAGI2, PRKCQ, RRAS2, PPP2R2B, CLDN9, MYLPF, LLGL1, AMOTL1, TJP3, PPP2CB, EPB41L2, F11R, RRAS, MYL9, CTTN, MYH3, PRKCE, VAPA, GNAI3, MYL12A, PARD6A, AFDN, MYL12B, PPP2R1A, KRAS, CRB3, TJAP1, AKT2, NRAS, CGN, CDC42, MRAS, PARD6B, MAGI1, OCLN, PRKCI, CSNK2B, CSNK2A1",0.417936637088291,0.219682687859849,FALSE
+"H460","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.27974,-0.968,0.447,15735,0.688,"MAPK11, IRAK4, TLR5, LY96, IFNAR2, FADD, MAPK10, TICAM2, PIK3CD, MAPK13, JUN, PIK3R3, RAC1, AKT2, RELA, IRF7, MAP3K7, MAPK3, MAPK1, MAPK14, TOLLIP, RIPK1, MAPK8, TRAF6, PIK3CA, TAB2",0.349692476868064,0.162411561764489,FALSE
+"H460","Input","KEGG_TRYPTOPHAN_METABOLISM",0.35466,1.28,0.161,2420,0.332,"KYNU, ALDH9A1, TDO2, CYP1B1, AADAT, HADH, ECHS1, ALDH3A2, AFMID, ALDH1B1, HADHA, ACAT1, OGDH",0.79317412396815,0.478861916295964,FALSE
+"H460","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.37996,-1.32,0.12,11667,0.389,"ABCC8, CACNA1B, HK3, MAFA, GCK, PIK3R2, CACNA1G, KCNJ11, TNF, SLC2A4, PIK3CB, PRKCD, PRKCZ, PIK3R1, CACNA1A, CACNA1D, MAPK10, PRKCE, SOCS1, PIK3CD, PIK3R3, MAPK3, INSR, MAPK1, MAPK8, PIK3CA",0.920818753952375,0.410050398674292,FALSE
+"H460","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.31748,1.15,0.25,1387,0.374,"HSPD1, PTPRN",0.602059991327962,0.42712839779952,FALSE
+"H460","Input","KEGG_TYROSINE_METABOLISM",0.34995,1.24,0.182,2003,0.334,"ALDH3A1, GOT2, BUD23, HPD, AOC3, ALDH3B1, FAH",0.739928612014925,0.476253533188435,FALSE
+"H460","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.36309,-1.25,0.16,16073,0.428,"PLCG1, SOS1, NCK2, RAF1, PPP3CB, GSK3B, KRAS, PIK3CD, PAK6, PAK2, MAPK13, JUN, PIK3R3, PPP3CA, AKT2, NRAS, RELA, MAP3K7, NFKBIE, MAPK3, CBLB, MAPK1, CDC42, MAPK14, CBL, DLG1, SOS2, NFAT5, BCL10, FYN, PIK3CA",0.795880017344075,0.368556230986828,FALSE
+"H460","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.39165,-1.33,0.122,15969,0.429,"PIAS2, SMURF1, FZR1, FBXW8, TRIM37, UBE3B, UBE2B, CDC16, UBE2H, UBE2E3, NEDD4L, ELOC, RBX1, CDC34, HUWE1, UBE2E1, SOCS1, FBXO2, BIRC3, CUL5, CUL2, UBE2J1, TRIM32, PIAS1, BIRC2, CBLB, UBR5, UBE2R2, HERC3, FBXW7, UBA7, CBL, SYVN1, UBOX5, ITCH, RNF7, TRAF6, SIAH1, UBE2Q2, CUL7, MAP3K1, SMURF2, UBE2W",0.913640169325252,0.367542707815276,FALSE
+"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.73972,2.7,0,1031,0.0613,"IARS2, PDHA1, LARS2",Inf,1.21253952548158,TRUE
+"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.33712,1.22,0.175,3266,0.343,"HSD17B10, ALDH9A1, DLD, MCEE, HADH, ECHS1, ALDH3A2, ACADSB, ALDH1B1, HADHA, ACAT1, ACAA2, MCCC2, ACADS, HIBCH, IVD, OXCT1",0.756961951313706,0.464705879957229,FALSE
+"H460","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.26289,-0.912,0.517,13226,0.722,"ADCY4, PRKCH, PLA2G10, ROCK2, EDNRA, ACTG2, PRKCD, PRKCG, ADCY5, NPR2, PPP1R14A, PRKCQ, ADRA1B, GNAQ, GNA13, PLA2G12A, MYLK2, CACNA1D, PPP1CA, KCNMB4, CALML6, RAMP1, ADORA2B, MYL9, CALM3, KCNMA1, PRKCE, RAF1, ADORA2A, ITPR2, PPP1CB, KCNMB3, PRKACA, BRAF, ROCK1, MAPK3, MYL6B, MAPK1, ARHGEF12, PLA2G6, MYLK, ADCY6",0.286509456906058,0.141462802430361,FALSE
+"H460","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.30143,-1.05,0.342,16619,0.614,"CREB3L1, RAB11A, PRKACA, DYNLL2, ARHGDIB, ADCY6, RAB5A, RAB5B",0.465973893943865,0.211831628858832,FALSE
+"H460","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.34561,-1.19,0.223,16534,0.522,"SHC2, PTK2, RAF1, PPP3CB, KRAS, PIK3CD, MAPK13, PIK3R3, PPP3CA, RAC1, AKT2, NRAS, RAC2, MAPK3, MAPK1, CDC42, MAPKAPK2, VEGFA, MAPK14, PLA2G6, NFAT5, PIK3CA",0.651695136951839,0.282329496997738,FALSE
+"H460","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.2502,-0.866,0.619,11911,0.799,"TJP2, ATP6V1G1, CFTR, ATP6V0D2, TJP1, ATP6V1D, ATP6V1C2, KDELR2, KCNQ1, PRKCG, SEC61A2, ATP6V1G2, ERO1A, SEC61A1, ATP6V1B2, KDELR3, KDELR1, PLCG1, ATP6V1A, ATP6V1E1, PRKACA, ATP6V1C1, ATP6V1H, SEC61G",0.208309350979882,0.0974532206860086,FALSE
+"H460","Input","KEGG_VIRAL_MYOCARDITIS",-0.19476,-0.672,0.912,11242,0.977,"ABL2, SGCG, SGCA, DAG1, SGCD, MYH11, MYH15, LAMA2, EIF4G2, MYH7B, MYH9, CCND1, ITGB2, MYH3, EIF4G3, RAC1, RAC2, ICAM1, FYN",0.0400051616715838,0.0101054362812269,FALSE
+"H460","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.36756,-1.26,0.162,16027,0.423,"PSEN1, LEF1, TCF7, FZD2, MAPK10, RBX1, CSNK1A1, APC, FZD6, PPP3CB, GSK3B, PPP2R1A, PRICKLE2, PORCN, WNT9A, JUN, VANGL2, PPP3CA, RAC1, PRKACA, EP300, MAP3K7, LRP6, ROCK1, FRAT1, RAC2, CSNK1E, PPP2R5E, WNT7B, TCF7L1, CREBBP, NLK, SMAD3, CTNNBIP1, MAPK8, SIAH1, NFAT5, CSNK2B, SENP2, DVL3, PPARD, TBL1XR1, CSNK2A1, PPP2R5B, DAAM1",0.790484985457369,0.373659632624958,FALSE
+"H1299","Input","KEGG_ABC_TRANSPORTERS",-0.27792,-1.03,0.38,13038,0.664,"ABCA9, ABCA10, ABCC8, ABCB11, ABCC9, ABCA8, ABCB4, ABCA6, ABCC2, ABCG1, ABCA13, ABCA4, ABCA12, ABCB10, ABCB6, ABCC6, ABCG2, ABCD3, ABCA2, ABCA5, ABCC3, ABCC1",0.42021640338319,0.177831920631982,FALSE
+"H1299","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.29126,-1.03,0.351,17481,0.664,"PPARD, IKBKB, STAT3, MAPK3, STAT5A, RARA, JUP, STAT5B, ARAF",0.454692883534176,0.177831920631982,FALSE
+"H1299","Input","KEGG_ADHERENS_JUNCTION",-0.36884,-1.36,0.106,15231,0.356,"BAIAP2, LMO7, CREBBP, ACP1, RAC1, TGFBR1, SRC, PTPRB, ERBB2, IGF1R, CTNNA1, NECTIN4, CDH1, NLK, FER, CTNND1, SORBS1, EP300, MAPK3, NECTIN1, PTPN6, SNAI2, RAC2, PTPRM",0.97469413473523,0.448550002027125,FALSE
+"H1299","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.1888,-0.694,0.899,17457,0.952,"SLC2A1, ADIPOR1, CPT1C, IKBKB, ACSL5, PPARA, STAT3, RXRA, IRS2",0.0462403082667712,0.0213630516155257,FALSE
+"H1299","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.41181,-1.52,0.0708,14401,0.295,"GLS2, IL4I1, GLUD2, GLS, GFPT2, ACY3, GPT, DDO, GLUL, CPS1, ABAT, GFPT1, NIT2, ASS1",1.14996674231023,0.530177984021837,FALSE
+"H1299","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.25321,0.866,0.618,2526,1,"PIK3CG, SCNN1G, SCNN1B, ATP1A3, PIK3CB, SGK1, PRKCG",0.209011524911184,0,FALSE
+"H1299","Input","KEGG_ALLOGRAFT_REJECTION",0.22332,0.75,0.771,14847,1,"CD40, IL12A, IFNG, CD28, CD40LG, IL2, FASLG, IL12B, CD80, PRF1, FAS, IL4, IL10, CD86, GZMB, IL5, TNF",0.112945621949043,0,FALSE
+"H1299","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.42904,-1.55,0.0665,10518,0.302,"PLA2G12B, PLA2G4B, PLA2G5, PLA2G2C, PLA2G2F, PLA2G4E, PLA2G2A, PLA2G3, PLA2G6, PLA2G10, ACOX1, FADS2, PLA2G4A, PLA2G12A",1.1771783546969,0.519993057042849,FALSE
+"H1299","Input","KEGG_ALZHEIMERS_DISEASE",-0.19494,-0.714,0.845,14669,0.95,"UQCRQ, NDUFA4, NDUFA4L2, ITPR3, TNF, CYCS, LPL, GRIN2C, CACNA1D, CAPN1, ADAM10, NDUFC2, BID, CDK5R1, NDUFV1, CACNA1C, NDUFB8, ITPR1, ATP2A3, COX6B2, BACE1, IL1B, GNAQ, NDUFS4, GSK3B, LRP1, NDUFB4, PSEN2, ATP5F1C, PLCB2, IDE, CASP8, NDUFA3, NDUFA1, UQCRC2, SNCA, BACE2, APH1A, MAPK3, ATF6, FADD, CASP7, EIF2AK3, PPP3CB",0.0731432910503077,0.0222763947111523,FALSE
+"H1299","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.41419,1.39,0.114,2864,0.585,"VARS2, DARS2, YARS2, RARS2, PSTK, FARSA, AARS2",0.943095148663527,0.23284413391782,FALSE
+"H1299","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.37932,-1.35,0.131,16173,0.358,"GFPT2, GMPPA, HEXA, RENBP, PGM1, GALE, NPL, NANP, HK1, MPI, GFPT1, NAGK, CYB5R1, PMM2",0.882728704344236,0.446116973356126,FALSE
+"H1299","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.24191,-0.885,0.605,17291,0.766,"RAB5A, MAPK13, CCS, MAP2K6, CASP1, CAT, PPP3CB, GPX1",0.218244625347531,0.115771230367396,FALSE
+"H1299","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.23634,0.811,0.694,1584,1,"HSP90AA1, IFNA13, HSP90AB1, HSPA1L, HSPA8, NFYC, HSPA1A, HSPA1B",0.158640529545145,0,FALSE
+"H1299","Input","KEGG_APOPTOSIS",-0.20417,-0.758,0.786,14618,0.958,"EXOG, CASP6, IL1R1, TNF, BAX, CYCS, ENDOD1, IL3RA, CAPN1, BID, IKBKG, IL1A, IL1B, CHUK, PRKACB, NGF, TNFRSF10B, CASP8, IKBKB, TNFSF10, XIAP, FADD, CASP10, CASP7, PPP3CB, MYD88",0.104577453960592,0.0186344909214556,FALSE
+"H1299","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.46892,-1.66,0.049,11297,0.277,"PLA2G5, CBR1, PLA2G2C, PLA2G2F, ALOX15B, CYP2C19, CYP2C9, CYP2E1, PLA2G4E, CYP2B6, PLA2G2A, CYP4A22, CYP4F2, PLA2G3, CYP2C18, PLA2G6, ALOX15, CYP2J2, GGT6, GGT5, PTGES, PTGIS, PLA2G10, TBXAS1, CYP4F3, ALOX5, GPX2, LTC4S, PTGS1, GPX7, PTGS2, GPX3, GGT1, PLA2G4A, AKR1C3, PLA2G12A, GPX1",1.30980391997149,0.557520230935551,FALSE
+"H1299","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.23539,-0.888,0.573,14340,0.777,"AOC1, GLS2, CKMT2, SAT2, CKMT1B, GLUD2, MAOB, GLS, GLUL, AGMAT, PRODH, PYCR2, ALDH18A1, CPS1, P4HA2, ALDH2, P4HA1, ASS1",0.24184537803261,0.109578981199086,FALSE
+"H1299","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.28537,0.961,0.499,1220,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, ITGA6, CACNA2D1",0.30189945437661,0,FALSE
+"H1299","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.43031,-1.54,0.0669,9337,0.299,"UGT2B10, UGT2B11, UGT2B17, ALDH1B1, UGT2B4, UGDH, ALDH9A1, UGT2A1, UGT2A3, UGT2B15, MIOX, UGT2B7, ALDH2",1.17457388223218,0.52432881167557,FALSE
+"H1299","Input","KEGG_ASTHMA",0.2233,0.76,0.804,14847,1,"CD40, EPX, IL13, IL9, MS4A2, FCER1A, CD40LG, IL3, CCL11, IL4, IL10, PRG2, RNASE3, FCER1G, IL5, TNF",0.0947439512515487,0,FALSE
+"H1299","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.22689,0.783,0.741,1138,1,"IFNA13, CD40",0.130181792020672,0,FALSE
+"H1299","Input","KEGG_AXON_GUIDANCE",-0.40171,-1.49,0.0608,15000,0.27,"EFNB1, ABLIM2, PLXNC1, SRGAP3, CXCL12, UNC5A, SEMA4D, EPHB1, RAC1, FES, EPHA6, SLIT2, NTNG1, EPHB6, NTN4, CXCR4, GSK3B, EFNA5, NFATC2, SEMA3A, EFNA3, SEMA5A, EPHA1, EPHA4, EFNA1, PAK6, NRP1, EPHB2, EPHB3, SEMA7A, UNC5B, SEMA3F, ABLIM3, NCK2, PLXNB2, SEMA3B, L1CAM, LIMK2, MAPK3, RHOD, PLXNB1, RAC2, PLXNA2, PLXNB3, ABLIM1, PLXNA3, EFNA4, PPP3CB",1.21609642072727,0.568636235841013,FALSE
+"H1299","Input","KEGG_BASAL_CELL_CARCINOMA",0.17837,0.608,0.972,4094,1,"WNT16, FZD9, APC2, WNT5B, DVL1, PTCH2, GLI1, SMO, WNT9A, STK36, FZD7, SHH, FZD1, DVL2",0.0123337350737254,0,FALSE
+"H1299","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.34503,1.19,0.201,1899,0.843,"TBP, GTF2H4, TAF9, TAF9B, TAF6, TBPL1, TAF2, TAF5",0.696803942579511,0.0741724253752577,FALSE
+"H1299","Input","KEGG_BASE_EXCISION_REPAIR",0.29973,1.03,0.365,2724,1,"XRCC1, POLE3, POLE2, NEIL2, UNG, POLD1, POLE",0.437707135543525,0,FALSE
+"H1299","Input","KEGG_BETA_ALANINE_METABOLISM",0.18782,0.646,0.925,1279,1,"SMS, GAD1",0.0338582672609674,0,FALSE
+"H1299","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29646,0.997,0.438,3901,1,"ELOVL2, ACOT7, ACOT2, ELOVL5, ACOX3, SCD",0.3585258894959,0,FALSE
+"H1299","Input","KEGG_BLADDER_CANCER",-0.45861,-1.68,0.0351,16909,0.319,"ERBB2, DAPK2, FGFR3, EGF, CDH1, MMP2, CXCL8, MAPK3, VEGFA, VEGFB, DAPK1, ARAF",1.45469288353418,0.496209316942819,FALSE
+"H1299","Input","KEGG_BUTANOATE_METABOLISM",-0.37555,-1.36,0.129,15843,0.356,"HMGCL, OXCT1, HADH, AKR1B10, AACS, HMGCS1, ACSM3, ABAT, ALDH2, BDH1, BDH2",0.889410289700751,0.448550002027125,FALSE
+"H1299","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.25418,-0.927,0.506,15494,0.755,"RASGRP3, IKBKG, VAV1, RAC1, BLNK, SOS2, CD81, PLCG2, CHUK, GSK3B, DAPP1, NFATC2, CARD11, SYK, IKBKB, VAV3, MAPK3, PTPN6, IFITM1, RAC2, PPP3CB",0.295849483160201,0.122053048370812,FALSE
+"H1299","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.22894,0.771,0.764,2526,1,"PTGER1, NTSR1, CACNA1A, P2RX5, CACNA1B, GRIN2D, PLCD4, ADORA2A, ADRA1B, TBXA2R, SLC8A1, TRPC1, CALM1, MYLK2, PHKA1, F2R, PLCB4, SLC25A31, NOS3, PHKG2, ADORA2B, PRKCG",0.11690664142431,0,FALSE
+"H1299","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.41512,1.42,0.1,2224,0.679,"COX7B2, CACNG7, CACNB4, CACNG8, CACNG6, COX8C, SLC8A1, UQCRFS1, TPM2, CACNA2D1, CYC1, ATP1A3, UQCRB, COX6B1, COX4I1",1,0.168130225719498,FALSE
+"H1299","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.2909,-1.07,0.317,13596,0.622,"CLDN14, CD22, ITGA9, ITGB7, CADM3, SELL, VCAM1, CDH5, CDH4, CLDN16, CLDN3, CD34, CLDN2, ITGB2, ESAM, ITGAV, NLGN4X, CD6, SDC3, CNTNAP2, NRXN2, CLDN9, CD8A, MPZ, CD276, F11R, NRXN3, CLDN11, VCAN, PDCD1LG2, SELPLG, NCAM1, MPZL1, CD58, NRCAM, CDH3, ICAM2, CLDN23, CLDN4, CD99, SDC2, CDH1, CLDN7, SDC1, CADM1, L1CAM, ITGB8, NECTIN1, ALCAM, PTPRM",0.498940737782249,0.206209615309181,FALSE
+"H1299","Input","KEGG_CELL_CYCLE",0.47877,1.65,0.0365,4683,0.4,"CCNA1, E2F5, PRKDC, MCM7, BUB1, ANAPC4, DBF4, ESPL1, CDC20, CDKN2D, CCNB1, TTK, ANAPC13, MCM4, CDK7, PLK1, ORC3, RAD21, YWHAQ, MAD2L2, PTTG1, CCNB2, TGFB1, CDKN2A, CDC14A, E2F2, YWHAZ, MCM2, CDKN2B, E2F3, CDC25C, CDC25A, CDK6, ANAPC1, CCNA2, HDAC2, CHEK1, SMC1A, SMC1B, ATR, FZR1, MCM6, HDAC1, CDKN2C, ANAPC7, MCM5, ANAPC5, E2F4, GADD45B, CCNE2, TGFB3, ORC1, CCNH, CDC45, YWHAB, CUL1, E2F1, CDC7, PTTG2, CHEK2, MAD1L1, ZBTB17, ORC2",1.43770713554353,0.397940008672038,FALSE
+"H1299","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.19879,-0.732,0.855,15596,0.968,"ADCY4, CXCL5, ADCY9, IKBKG, VAV1, RAC1, PRKCD, CXCL16, ADCY5, GRK7, CCL26, SHC3, CCL5, CXCR4, SOS2, CCL20, CHUK, GSK3B, PRKACB, ADCY6, CX3CL1, GRK2, CCL2, ADCY1, GNG2, ARRB1, PLCB2, STAT2, STAT1, IKBKB, VAV3, ADCY7, FOXO3, STAT3, RAP1A, CXCL8, MAPK3, RAC2, PTK2B, STAT5B",0.0680338852718274,0.0141246426916063,FALSE
+"H1299","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.25172,0.858,0.624,3777,1,"PIK3CG, MECOM, TGFB1, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, HDAC2, CRK, CTBP1, PTPN11, CBL, AKT2, HDAC1, PIK3CD, NRAS, NFKB1, SHC1, RUNX1",0.204815410317576,0,FALSE
+"H1299","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.37612,-1.41,0.101,16225,0.314,"CLOCK, BHLHE40, PER2, NR1D1, CRY2",0.995678626217357,0.503070351926785,FALSE
+"H1299","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.38307,-1.41,0.0926,17118,0.314,"IDH3G, SUCLA2, FH, ACLY, MDH1, IDH1, PC, IDH2",1.03338901331807,0.503070351926785,FALSE
+"H1299","Input","KEGG_COLORECTAL_CANCER",0.25852,0.887,0.585,5438,1,"PIK3CG, FOS, TGFB1, APC2, AKT1, APPL1, PIK3CB, AKT2, RAC3, PIK3CD, MSH3, BIRC5, MSH6, TGFB3, BAD, MLH1, RHOA, MSH2, MAPK9, PIK3R3, RAF1, MYC, JUN, MAPK10, SMAD4, CASP9",0.23284413391782,0,FALSE
+"H1299","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.36445,-1.31,0.155,11642,0.375,"C5, F7, MASP1, FGA, F13A1, C6, PROS1, C4BPA, CR2, SERPIND1, FGG, FGB, F5, C5AR1, SERPING1, PLG, F8, A2M, C3AR1, VWF, SERPINA5, KLKB1, C4BPB, SERPINF2, TFPI, BDKRB1, PROC, CFI, PLAT, THBD, C2, BDKRB2, CD55, CFH, C3, C1S, CFB, F3, C1R, CD46",0.809668301829709,0.425968732272281,FALSE
+"H1299","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.29925,1.02,0.369,5315,1,"CDO1, SMS, DNMT1, AHCY, CBS, LDHB, SRM, MTAP, ADI1, DNMT3A, APIP, TRDMT1, AMD1, AHCYL2",0.43297363384094,0,FALSE
+"H1299","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.25288,-0.95,0.466,11532,0.732,"OSM, CX3CR1, IL10, IFNW1, CXCL9, CCL24, IL19, PF4, PDGFB, PPBP, IL12RB2, CCR9, IFNA21, CCL3L3, IL18RAP, IL1RAP, CCL25, TNFSF9, TNFSF4, IFNL2, LIF, IFNA8, IFNL3, IL10RB, CCL15, LIFR, IL2RA, CLCF1, IL23A, CCL3, TPO, IL2RB, LEPR, IL17B, IL13RA1, TNFRSF4, CCL22, EGFR, IFNA1, CCR3, IFNA5, CSF3, IFNL1, MET, KIT, IFNB1, CCR1, PRLR, KDR, EDAR, RELT, CXCL11, CCL17, TNFSF18, HGF, CXCL1, CCR7, CRLF2, FLT1, TNFSF14, CXCL3, CNTFR, IL20RA, IL12RB1, TSLP, IL5, TNFSF13B, IFNGR1, CXCL6, CXCL14, IL1R1, TNF, CXCL10, BMPR1A, IL21R, ACVRL1, IL3RA, IL2RG, IL24, IL17RB, IL7R, CXCL12, TNFSF15, PDGFRA, CD27, IL20RB, CXCL5, TNFRSF18, CSF2, CSF2RA, CSF1R, CXCL16, EDA2R, CCL26, IL1A, CCL5, IL1B, CXCR4, NGFR, IL22RA1, IL11, CCL20, TGFBR1, PDGFRB, IL1R2, TNFRSF11B, INHBE, TNFRSF10B, INHBB, CX3CL1, BMP2, IL15, CCL2, IFNLR1, IL6, EGF, INHBA, TNFRSF19, IL15RA, TNFSF10, TNFRSF21, TNFSF13, IL6R, CSF1, CXCL8, TNFSF12, IL18, VEGFA, TNFRSF14, KITLG, FLT3LG, VEGFB, PDGFA, LTBR",0.33161408331,0.135488918941608,FALSE
+"H1299","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.30995,-1.12,0.263,15724,0.57,"IKBKG, AIM2, POLR3B, CCL5, IL1B, CHUK, IL6, IKBKB, PYCARD, POLR1D, CASP1, MAVS, IKBKE, IL18, TREX1",0.580044251510242,0.244125144327509,FALSE
+"H1299","Input","KEGG_DILATED_CARDIOMYOPATHY",0.25915,0.893,0.593,1574,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, TPM2, ITGA6, CACNA2D1, TGFB1",0.226945306635737,0,FALSE
+"H1299","Input","KEGG_DNA_REPLICATION",0.59819,2.02,0.00448,3534,0.184,"MCM7, RFC1, MCM4, POLA1, PRIM1, RPA2, POLE3, POLE2, MCM2, POLD1, POLE, RFC2, RNASEH2A, RNASEH1, PRIM2, RPA1, MCM6, RFC5, MCM5",2.34872198600186,0.735182176990464,TRUE
+"H1299","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.2771,-1.01,0.383,16413,0.687,"SOS2, FMN2, NOTCH1, ETV7, ETS2, MAPK3",0.416801226031377,0.16304326294045,FALSE
+"H1299","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.41269,-1.47,0.0811,9885,0.284,"UGT2B11, UGT2B17, GSTA3, CYP2A13, FMO2, UGT2B4, ADH7, ADH4, CYP1A2, FMO1, UGT2A1, UGT2A3, GSTM5, CYP2C19, UGT2B15, GSTP1, GSTA2, CYP2A7, GSTM3, FMO3, CYP2C9, CYP2E1, CYP2B6, CYP3A4, GSTA1, MAOA, ADH1C, GSTM4, CYP2C18, CYP2A6, GSTO1, CYP3A7, UGT2B7, GSTM1, MAOB, ALDH3B2, FMO5, MGST3, CYP3A5, MGST1, GSTZ1, ALDH1A3, CYP2D6, ALDH3A1, GSTO2, GSTT2, FMO4, MGST2",1.09097914578884,0.546681659952962,FALSE
+"H1299","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.17863,-0.67,0.937,11225,0.964,"UGT2A1, CES5A, UPB1, UGT2A3, UGT2B15, CYP2A7, TYMP, DPYS, CYP3A4, CYP2A6, NAT2, TK2, CES1, CYP3A7, UPP1, UGT2B7, CES2, CYP3A5, CDA, NAT1",0.0282604091122217,0.0159229660971692,FALSE
+"H1299","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.38238,-1.41,0.1,14594,0.314,"VTN, THBS2, ITGAV, VWF, CD36, COL5A3, SDC3, ITGA11, HSPG2, COL6A3, THBS1, ITGA1, COL1A2, COL3A1, COL4A4, CHAD, LAMA4, FN1, COL4A6, LAMA1, LAMC1, ITGB6, GP1BB, ITGB4, AGRN, TNC, COL5A2, SDC2, LAMB1, COL5A1, SV2A, LAMA3, SDC1, ITGB8, COL1A1, COL4A1, COL4A2",1,0.503070351926785,FALSE
+"H1299","Input","KEGG_ENDOCYTOSIS",-0.22064,-0.799,0.703,15437,0.902,"VPS37C, PDGFRA, MDM2, ERBB3, AGAP2, PIP4K2B, PSD, CSF1R, NEDD4L, TFRC, RAB22A, GRK7, ARAP2, STAM, CXCR4, ARF6, SRC, EPS15, CHMP6, STAMBP, DNM1, GRK2, EPN3, CBLC, RAB5A, CHMP4B, IGF1R, LDLRAP1, ARRB1, ARFGAP2, FGFR3, CHMP2B, RAB11FIP1, ARAP1, EGF, RAB5B, FGFR2, RAB11FIP4, PARD6B, PARD6G, ACAP3, CBLB, TSG101, RAB5C, VPS25, PSD4, TRAF6",0.153044674980176,0.0447934624580583,FALSE
+"H1299","Input","KEGG_ENDOMETRIAL_CANCER",-0.24859,-0.922,0.52,16413,0.758,"SOS2, GSK3B, ERBB2, PDPK1, CTNNA1, EGF, CDH1, FOXO3, MAPK3, ARAF",0.283996656365201,0.120330794367946,FALSE
+"H1299","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.23971,-0.887,0.564,15427,0.77,"ADAM10, ATP6V0A1, IKBKG, ATP6V1E1, RAC1, ATP6V1A, ATP6V0A4, ATP6V1B2, CCL5, ATP6V1G2, F11R, PLCG2, CHUK, SRC, MAPK13, IKBKB, ATP6V1B1, ATP6AP1, ATP6V0E1, CXCL8",0.248720896016658,0.113509274827518,FALSE
+"H1299","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.26719,-0.997,0.417,15648,0.695,"RPS6KB2, ERBB3, CAMK2B, SHC3, SOS2, NRG4, PLCG2, SRC, GSK3B, ERBB2, EREG, CBLC, BTC, PAK6, EGF, AREG, NCK2, GAB1, MAPK3, CBLB, STAT5A, STAT5B, ARAF",0.379863945026242,0.158015195409886,FALSE
+"H1299","Input","KEGG_ETHER_LIPID_METABOLISM",-0.192,-0.688,0.91,16979,0.951,"LPCAT2, PLPP3, PLA2G4A, PLA2G12A",0.0409586076789064,0.0218194830625861,FALSE
+"H1299","Input","KEGG_FATTY_ACID_METABOLISM",-0.21241,-0.79,0.749,13073,0.91,"ACSL6, CYP4A22, ADH1C, ACSL4, ECHS1, CPT2, CPT1B, EHHADH, ACSL1, ACOX1, ACAA1, HADHB, HADH, CPT1C, ACSL5, ALDH2",0.125518182300534,0.0409586076789064,FALSE
+"H1299","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.18973,-0.698,0.92,13586,0.965,"PLA2G3, FCER1G, PLA2G6, GAB2, PRKCA, MAPK8, INPP5D, IL5, TNF, PLA2G10, CSF2, VAV1, RAC1, PRKCD, SOS2, PLCG2, PDPK1, SYK, MAPK13, VAV3, MAP2K6, PLA2G4A, MAPK3, RAC2, PLA2G12A",0.0362121726544447,0.0154726866562074,FALSE
+"H1299","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.18159,0.625,0.956,4882,1,"PIK3CG, VASP, ARPC1A, DNM1L, PIKFYVE, ASAP1, AKT1, ARPC1B, PIK3CB, PLPP2, CRK, PRKCG, WASF1, AKT2, PLD2, MYO10, PIK3CD, CFL2, ASAP3, WASF2, PRKCE, ASAP2, GSN, ARPC5L, LIMK1, FCGR3A, WASF3, PIK3R3",0.0195421077238999,0,FALSE
+"H1299","Input","KEGG_FOCAL_ADHESION",-0.20704,-0.761,0.796,15701,0.963,"COL6A3, VAV1, RAC1, THBS1, ITGA1, COL1A2, COL3A1, COL4A4, SHC3, SOS2, CHAD, SRC, GSK3B, PDGFRB, LAMA4, FN1, ERBB2, RASGRF1, COL4A6, LAMA1, LAMC1, PDPK1, ITGB6, ITGB4, IGF1R, PAK6, EGF, TNC, COL5A2, VAV3, LAMB1, COL5A1, LAMA3, XIAP, RAP1A, ITGB8, MAPK3, COL1A1, VEGFA, ARHGAP5, RAC2, VEGFB, COL4A1, COL4A2, PDGFA, PPP1CB",0.0990869322623309,0.0163737128754655,FALSE
+"H1299","Input","KEGG_FOLATE_BIOSYNTHESIS",0.24073,0.828,0.681,4660,1,"GGH, SPR, DHFR, PTS",0.166852888087215,0,FALSE
+"H1299","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.55088,-1.95,0.0205,15333,0.308,"FPGT, ALDOA, FBP1, PFKFB3, GMPPA, AKR1B10, PFKFB4, PFKFB2, MTMR6, HK1, MPI, ALDOC, PMM2",1.68824613894425,0.511449283499556,FALSE
+"H1299","Input","KEGG_GALACTOSE_METABOLISM",-0.3003,-1.08,0.291,16980,0.612,"PGM1, GALE, GLB1, HK1, B4GALT1",0.536107011014093,0.213248577854439,FALSE
+"H1299","Input","KEGG_GAP_JUNCTION",-0.26765,-0.979,0.431,14284,0.695,"PRKCA, GUCY1A1, DRD2, TUBAL3, ITPR3, HTR2C, PDGFRA, ADCY4, ADCY9, TUBA8, ITPR1, ADCY5, LPAR1, TUBA3D, GNAQ, SOS2, SRC, PDGFRB, PRKACB, ADCY6, ADCY1, PLCB2, EGF, ADCY7, GJA1, MAPK3, PDGFA, TUBA4A",0.365522729839268,0.158015195409886,FALSE
+"H1299","Input","KEGG_GLIOMA",0.22609,0.785,0.755,3610,1,"PIK3CG, CALM1, MTOR, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, PRKCG, AKT2, PIK3CD, NRAS, SHC1",0.122053048370812,0,FALSE
+"H1299","Input","KEGG_GLUTATHIONE_METABOLISM",-0.41264,-1.51,0.0595,16112,0.282,"GGCT, GPX2, GSR, MGST3, MGST1, GSTZ1, GCLC, GPX7, GSTO2, GSTT2, GPX3, GGT1, IDH1, G6PD, IDH2, MGST2, GPX1",1.22548303427145,0.549750891680639,FALSE
+"H1299","Input","KEGG_GLYCEROLIPID_METABOLISM",0.21209,0.733,0.827,2239,1,"GPAT2, AGPAT1, GPAT3, DGAT2, DGKE, PLPP2",0.0824944904474534,0,FALSE
+"H1299","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.23145,0.787,0.745,2728,1,"GPAT2, PEMT, AGPAT1, LYPLA1, GPAT3, CHPT1, ACHE, DGKE, PLPP2, ETNK1, PTDSS1, LPCAT3",0.127843727251707,0,FALSE
+"H1299","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.21311,0.713,0.876,804,1,"GLDC, ALAS1",0.0574958938319193,0,FALSE
+"H1299","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.2349,-0.85,0.652,15309,0.809,"PCK2, ALDH3B2, ALDOA, FBP1, ALDH1A3, LDHA, PGM1, ALDH3A1, HK1, ALDH2, ACSS1, ALDOC, AKR1A1",0.18575240426808,0.0920514783877277,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.18115,-0.665,0.945,14570,0.96,"B3GAT1, B3GAT3, CHPF, B4GALT7, XYLT1, CHST15",0.0245681914907371,0.0177287669604316,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35545,-1.3,0.136,13971,0.37,"EXTL1, B3GAT1, B3GAT3, B4GALT7, EXT1, GLCE, XYLT1, HS6ST1, HS3ST1, HS6ST2, EXT2",0.866461091629782,0.431798275933005,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.57759,-2.1,0.00773,15489,0.299,"CHST1, CHST6, ST3GAL3, B3GNT7, B3GNT2, ST3GAL1, B4GALT4, B4GALT1",2.11182050608168,0.52432881167557,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.41674,-1.51,0.0653,16808,0.282,"HEXA, GLB1, IDUA, IDS, HGSNAT, NAGLU",1.18508681872493,0.549750891680639,FALSE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.33653,1.14,0.27,4284,0.871,"ST6GALNAC4, ST6GALNAC6, ST8SIA5, B4GALNT1, ST3GAL2, ST6GALNAC3, ST8SIA1",0.568636235841013,0.0599818449923368,FALSE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.52051,-1.9,0.012,16808,0.258,"HEXA, GBGT1, FUT2, ST3GAL1, FUT1, B3GALNT1",1.92081875395238,0.58838029403677,FALSE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.40077,-1.45,0.0889,15219,0.297,"B3GALT5, ST3GAL4, ABO, ST3GAL3, FUT3, B3GNT3, B3GNT2, FUT2, B4GALT4, FUT1, B4GALT1",1.05109823902979,0.527243550682788,FALSE
+"H1299","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.27392,-1.01,0.391,14781,0.687,"PIGY, PIGK, PIGM, PIGQ, PIGC, PIGB, PIGV, PIGS",0.407823242604133,0.16304326294045,FALSE
+"H1299","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.4312,1.45,0.0734,3418,0.679,"MDH2, MTHFD1L, MTHFD2L, MTHFD1, CS, GRHPR",1.13430394008393,0.168130225719498,FALSE
+"H1299","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.24188,-0.867,0.597,14832,0.789,"ITPR3, PLA2G10, ATF4, CACNA1D, ADCY4, CACNA1C, ADCY9, ITPR1, PRKCD, CAMK2B, ADCY5, GNAQ, SOS2, SRC, PRKACB, ADCY6, ADCY1, MAPK13, PLCB2, MMP2, ADCY7, MAP2K6, PLA2G4A, MAPK3, PLA2G12A, MAP3K1, PTK2B",0.224025668870631,0.10292299679058,FALSE
+"H1299","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.45297,-1.62,0.0408,8677,0.269,"IFNG, CD28, KIR2DL1, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, FAS, KLRC1, CD86, GZMB, TNF, IL1A, IL1B, IL6",1.38933983691012,0.570247719997592,FALSE
+"H1299","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.20398,-0.715,0.852,16658,0.958,"GSK3B, PRKACB, WNT11, GAS1, BMP2, SUFU, GLI2, BMP4, WNT5A, BTRC, WNT7B",0.0695604052332999,0.0186344909214556,FALSE
+"H1299","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.24664,-0.898,0.563,13245,0.764,"CD3D, THPO, CD7, CSF3, KIT, CD22, CD33, CD34, IL5, CD1D, IL1R1, TNF, IL3RA, CD36, IL7R, FCGR1A, CSF2, CD14, CSF2RA, CSF1R, TFRC, ITGA1, CD8A, IL1A, IL1B, IL11, IL1R2, GP1BB, IL6, CD55, IL6R, CSF1, KITLG, FLT3LG",0.249491605148654,0.11690664142431,FALSE
+"H1299","Input","KEGG_HISTIDINE_METABOLISM",0.27812,0.959,0.471,397,1,"FTCD, BUD23",0.326979092871104,0,FALSE
+"H1299","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.6082,2.05,0.00158,3832,0.243,"XRCC3, EME1, RAD54L, RAD51C, RAD54B, RAD52, RPA2, TOP3A, RAD51B, SEM1, POLD1, RAD51, RPA1, NBN, XRCC2",2.80134291304558,0.614393726401688,TRUE
+"H1299","Input","KEGG_HUNTINGTONS_DISEASE",0.27481,0.94,0.512,3801,1,"COX7B2, DNAI1, TBP, POLR2D, COX8C, NDUFB9, UQCRFS1, IFT57, TBPL1, POLR2I, POLR2A, NDUFA9, CYC1, PLCB4, TGM2, SLC25A31, SDHB, DLG4, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, HIP1, HDAC2, ATP5F1B, CLTA, RCOR1, TFAM, DNAL1, POLR2K, COX8A, NDUFS6, NDUFV2, SLC25A6, COX6C, HDAC1, HTT, POLR2J, TAF4B, NDUFB1, POLR2E, CLTC",0.290730039024169,0,FALSE
+"H1299","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30585,1.04,0.356,1574,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, TPM2, PRKAG2, ITGA6, CACNA2D1, TGFB1",0.448550002027125,0,FALSE
+"H1299","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.26101,0.901,0.565,2189,1,"PIK3CG, ISYNA1, IMPA1, PLCD4, INPP5E, PIKFYVE, PLCB4, PIK3CB",0.247951552180562,0,FALSE
+"H1299","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.1952,-0.716,0.876,16279,0.965,"SHC3, EIF4E2, PRKAB2, SOS2, GSK3B, PRKACB, PHKB, GYS1, MKNK1, PPP1R3B, PDPK1, PPP1R3D, CBLC, IKBKB, SOCS4, PHKG1, FLOT2, SORBS1, HK1, MAPK3, FOXO1, CBLB, PPP1CB, IRS2, ARAF",0.0574958938319193,0.0154726866562074,FALSE
+"H1299","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.29015,0.974,0.467,1574,1,"MAP3K14, ITGA4, MADCAM1, CD40, TGFB1",0.330683119433888,0,FALSE
+"H1299","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.19629,-0.724,0.897,14369,0.972,"CNTFR, IL20RA, IL12RB1, TSLP, IL5, SPRY3, IFNGR1, IL21R, IL3RA, IL2RG, IL24, SOCS1, IL7R, PIAS1, IL20RB, CREBBP, CSF2, CSF2RA, STAT6, STAM, SOS2, IL22RA1, IL11, SOCS5, CISH, IL15, CBLC, STAT4, IFNLR1, IL6, STAT2, STAT1, IL15RA, SOCS4, STAT3, EP300, IL6R, PTPN6, IRF9, CBLB, STAT5A, STAT5B",0.0472075569559079,0.0123337350737254,FALSE
+"H1299","Input","KEGG_LEISHMANIA_INFECTION",-0.24432,-0.903,0.567,15945,0.761,"FCGR2A, IL1A, IL1B, TAB1, TLR2, TLR4, NCF2, PTGS2, MAPK13, STAT1, C3, MAPK3, PTPN6, TRAF6, MYD88",0.246416941107093,0.118615343229427,FALSE
+"H1299","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19773,0.675,0.908,4294,1,"PIK3CG, ITGAM, ITGA4, VASP, CLDN20, PXN, JAM3, BCAR1, MAPK11, MAPK12, PIK3CB, PTK2, CYBB, PRKCG, CLDN15, EZR, PTPN11, SIPA1, ICAM1, MYL9, PIK3CD, ACTG1, VCL, MYL12A, GNAI2, OCLN, MYL12B, MMP9, AFDN, CYBA",0.0419141514789149,0,FALSE
+"H1299","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.47181,-1.71,0.0387,14291,0.377,"ECHS1, EHHADH, YOD1, ALDH2",1.41228903498109,0.423658649794207,FALSE
+"H1299","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.49029,-1.79,0.0274,10518,0.35,"PLA2G12B, CYP1A2, PLA2G4B, PLA2G5, PLA2G2C, PLA2G2F, CYP2C19, CYP2C9, CYP2E1, PLA2G4E, CYP3A4, PLA2G2A, PLA2G3, CYP2C18, PLA2G6, ALOX15, CYP2J2, PLA2G10, CYP3A7, CYP3A5, AKR1B10, PLA2G4A, PLA2G12A",1.56224943717961,0.455931955649724,FALSE
+"H1299","Input","KEGG_LONG_TERM_DEPRESSION",-0.17187,-0.623,0.961,11611,0.967,"PLA2G2F, GNA12, PPP2CB, GNAI3, PRKG2, GNA13, PRKCB, NOS1, PLA2G4E, GRID2, PLA2G2A, CRHR1, IGF1, PLA2G3, GRIA3, PLCB1, PLA2G6, PRKCA, GUCY1A1, PPP2R1A, ITPR3, PLA2G10, ITPR1, GNAO1, GNAQ, RYR1, IGF1R, PLCB2, PLA2G4A, MAPK3, PLA2G12A, ARAF",0.0172766123314547,0.0145735259169983,FALSE
+"H1299","Input","KEGG_LONG_TERM_POTENTIATION",-0.29678,-1.09,0.308,14832,0.6,"ITPR3, ATF4, GRIN2C, CREBBP, CACNA1C, ITPR1, RPS6KA1, CAMK2B, GNAQ, PRKACB, ADCY1, PLCB2, EP300, RAP1A, MAPK3, RPS6KA2, PPP1CB, PPP3CB, ARAF",0.511449283499556,0.221848749616356,FALSE
+"H1299","Input","KEGG_LYSINE_DEGRADATION",0.20615,0.714,0.874,3083,1,"EHMT2, NSD2, KMT5A, SETD1A, DLST, ACAT2, EHMT1, DOT1L",0.058488567365597,0,FALSE
+"H1299","Input","KEGG_LYSOSOME",-0.35284,-1.29,0.127,14720,0.375,"AP3S2, SLC11A2, NPC2, GNS, TPP1, PPT1, HYAL1, ATP6V0A1, GM2A, CD63, SMPD1, ATP6V0A4, GBA, GGA2, ACP5, GNPTAB, HEXA, CTSO, CTSH, ACP2, CTSB, ABCA2, GLB1, AGA, IDUA, CLN5, ARSA, ATP6AP1, FUCA1, GNPTG, SCARB2, LIPA, CTSS, LAMP1, IDS, CTSD, ASAH1, LAPTM4A, LAMP2, PSAP, HGSNAT, NAGLU, SUMF1",0.896196279044043,0.425968732272281,FALSE
+"H1299","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.20847,0.703,0.871,3714,1,"CACNA1A, CACNG7, CACNB4, MAP3K14, CACNG8, CACNG6, CACNA1B, RELB, FLNC, NFKB2, NR4A1, DAXX, FOS, MEF2C, HSPA1L, HSPA8, FGF5, MAP3K12, CACNA2D1, SRF, STK4, MAP2K3, MAPK8IP2, FGF12, PAK2, HSPA1A, MECOM, TGFB1, MAP3K7, HSPA1B, MAPK11, RASGRP2, AKT1, MAP3K5, MAP2K2, DUSP1, MAPK12, FGF11, CRK, MAPKAPK3, PRKCG, TNFRSF1A, AKT2, RAC3, TRAF2, ECSIT, RRAS, HSPB1, JUND, MAPK7, MAP3K3, FGF1, PPP3R2, NRAS, NFKB1, MAP4K4, RPS6KA4, MAPK8IP1, ARRB2",0.0599818449923368,0,FALSE
+"H1299","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.22963,0.798,0.731,208,1,"GCK",0.13608262304214,0,FALSE
+"H1299","Input","KEGG_MELANOGENESIS",-0.22376,-0.812,0.678,15411,0.883,"WNT4, WNT7A, ADCY4, CREBBP, ADCY9, GNAO1, CAMK2B, ADCY5, DVL3, GNAQ, GSK3B, PRKACB, WNT11, ADCY6, ADCY1, PLCB2, CREB3L2, MITF, ADCY7, WNT5A, EP300, EDN1, MAPK3, WNT7B, KITLG",0.168770306132937,0.0540392964224314,FALSE
+"H1299","Input","KEGG_MELANOMA",0.19777,0.666,0.913,3514,1,"PIK3CG, FGF5, FGF12, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, FGF11, AKT2, PIK3CD, FGF1, NRAS",0.039529222465701,0,FALSE
+"H1299","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.44672,-1.66,0.0193,11789,0.277,"AKR1C4, CYP2C19, UGT2B15, GSTP1, GSTA2, GSTM3, CYP2C9, CYP2E1, CYP1B1, CYP2B6, CYP2F1, CYP3A4, GSTA1, ADH1C, GSTM4, CYP2C18, GSTO1, AKR1C2, CYP3A7, UGT2B7, GSTM1, CYP1A1, ALDH3B2, MGST3, CYP3A5, MGST1, GSTZ1, ALDH1A3, ALDH3A1, AKR1C1, GSTO2, GSTT2, DHDH, EPHX1, CYP2S1, AKR1C3, MGST2",1.71444269099223,0.557520230935551,FALSE
+"H1299","Input","KEGG_MISMATCH_REPAIR",0.51204,1.78,0.0193,4775,0.418,"RFC1, RPA2, POLD1, RFC2, RPA1, RFC5, MSH3, MSH6, MLH1, POLD2, RFC4, MSH2",1.71444269099223,0.378823718224965,FALSE
+"H1299","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.24636,-0.916,0.532,17065,0.752,"PDPK1, MLST8, HIF1A, MAPK3, VEGFA, DDIT4, VEGFB, RPS6KA2",0.274088367704952,0.123782159408358,FALSE
+"H1299","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.17933,-0.648,0.96,14477,0.967,"KLRK1, SHC2, LCK, IFNGR1, ITGB2, TNF, KLRC2, RAET1G, BID, CSF2, VAV1, RAC1, SHC3, RAET1L, ULBP2, SOS2, SH3BP2, PLCG2, NFATC2, TNFRSF10B, ICAM2, SYK, VAV3, TNFSF10, MAPK3, PTPN6, RAC2, PTK2B, PPP3CB, ARAF",0.0177287669604316,0.0145735259169983,FALSE
+"H1299","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.27024,0.922,0.512,949,1,"PTGER1, GABRA4, NTSR1, MC5R, S1PR1, NPFFR2, P2RX5, NMUR1, CHRNB1, GABRD, F2RL1, GRIN2D, ADORA2A, GABRB3, ADRA1B, TBXA2R, P2RY1, ADRA2C, MC1R",0.290730039024169,0,FALSE
+"H1299","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.2068,0.704,0.877,3664,1,"PIK3CG, NFKBIB, CALM1, YWHAQ, ZNF274, SH2B3, IRAK2, MAPK11, AKT1, MAP3K5, MAP2K2, YWHAZ, PRDM4, MAPK12, NFKBIE, PSEN1, PIK3CB, CRK, RAPGEF1, PTPN11, AKT2, IRAK1, PIK3CD, TP73, MAPK7, MAP3K3, NRAS, NFKB1, SHC1, RPS6KA4",0.0570004066339595,0,FALSE
+"H1299","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48124,-1.72,0.0304,16535,0.404,"NT5C1B, NMNAT2, NAMPT, NT5C3A, NNMT, NMRK1, NADSYN1, QPRT, NUDT12, NNT",1.51712641639125,0.393618634889395,FALSE
+"H1299","Input","KEGG_NITROGEN_METABOLISM",-0.44836,-1.69,0.0289,14401,0.336,"GLS2, HAL, GLUD2, CA14, GLS, CA8, CTH, GLUL, CA9, AMT, CPS1, CA12",1.53910215724345,0.473660722610156,FALSE
+"H1299","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.27656,0.957,0.481,809,1,"HSP90AA1, CXCL2, CARD18, CARD8, NFKBIB, NLRP1, HSP90AB1, BIRC3",0.317854923626168,0,FALSE
+"H1299","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.2977,1,0.409,3035,1,"PRKDC, XRCC4, XRCC5",0.388276691992658,0,FALSE
+"H1299","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.23522,0.788,0.74,3514,1,"PIK3CG, STK4, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, PRKCG, AKT2, PIK3CD, NRAS",0.130768280269024,0,FALSE
+"H1299","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.26416,-0.966,0.452,16297,0.706,"CTBP2, DVL3, DTX1, MFNG, NOTCH1, MAML2, PSEN2, LFNG, DTX4, EP300, APH1A, CIR1, DTX3L",0.344861565188618,0.151195298948196,FALSE
+"H1299","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.40729,1.4,0.0978,3479,0.611,"ERCC1, RFC1, GTF2H4, CDK7, GTF2H5, RPA2, POLE3, ERCC3, POLE2, RAD23A, ERCC2, POLD1, POLE, RFC2, RPA1, RFC5",1.0096611452124,0.213958789757446,FALSE
+"H1299","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.2575,-0.948,0.484,14460,0.727,"ST6GAL1, MGAT3, MOGS, MAN2A1, MGAT5, MGAT1, ALG9, ALG5, STT3A, ALG2, MGAT4A, MAN1C1, ALG11, MAN1A2, B4GALT1",0.315154638355588,0.138465589140962,FALSE
+"H1299","Input","KEGG_OLFACTORY_TRANSDUCTION",0.20492,0.701,0.873,1072,1,"OR3A2, OR8G1, OR3A1, OR8D2, OR52H1, OR2J2, OR8G5, OR8A1, OR1F1, OR2W3, CALM1",0.0589857562944303,0,FALSE
+"H1299","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.50595,1.71,0.0295,4076,0.445,"FTCD, MTHFD1L, TYMS, MTHFD2L, MTHFD1, GART, DHFR, ATIC",1.53017798402184,0.351639989019068,FALSE
+"H1299","Input","KEGG_OOCYTE_MEIOSIS",0.33974,1.17,0.224,4362,0.861,"STAG3, FBXO43, BUB1, ANAPC4, ESPL1, CDC20, CCNB1, AURKA, CPEB1, ANAPC13, CALM1, PLK1, YWHAQ, MAD2L2, PTTG1, CCNB2, PPP2R5D, PPP2R5C, YWHAZ, MAPK12, CDC25C, ANAPC1, FBXO5, PPP1CC, SMC1A, SMC1B, SGO1, ITPR2, ANAPC7, PPP3R2, ANAPC5, CALM3, CCNE2, PRKX, PPP2R5E, YWHAB, CUL1, PTTG2",0.649751981665837,0.0649968485463452,FALSE
+"H1299","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.46715,-1.69,0.0385,15905,0.336,"MAN2C1, GBA, HEXA, ENGASE, GLB1, AGA, FUCA1",1.4145392704915,0.473660722610156,FALSE
+"H1299","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22936,0.786,0.74,3724,1,"COX7B2, COX8C, NDUFB9, UQCRFS1, ATP5ME, ATP6V1C1, NDUFA9, CYC1, SDHB, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, ATP6V1D, ATP5F1B, ATP6V0E2, NDUFA11, ATP6V1H, COX8A, NDUFS6, NDUFV2, COX6C, NDUFB1, COX10",0.130768280269024,0,FALSE
+"H1299","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.4609,-1.67,0.0345,15740,0.304,"ST6GALNAC1, GCNT4, GALNT6, GALNT9, GALNT2, GCNT3, GALNT5, GCNT1, GALNT1, ST3GAL1, GALNT7, GALNT3, GALNT12, B4GALT5",1.46218090492673,0.517126416391246,FALSE
+"H1299","Input","KEGG_P53_SIGNALING_PATHWAY",-0.20368,-0.751,0.842,14685,0.952,"PTEN, SESN3, BAX, TSC2, CYCS, MDM2, BID, CCNE1, DDB2, THBS1, TNFRSF10B, SERPINB5, GADD45G, ZMAT3, CASP8, MDM4, SIAH1, CCNG2, SFN, IGFBP3, COP1",0.0746879085003505,0.0213630516155257,FALSE
+"H1299","Input","KEGG_PANCREATIC_CANCER",-0.25745,-0.928,0.482,15724,0.763,"IKBKG, RAC1, ARHGEF6, TGFBR1, CHUK, ERBB2, EGF, STAT1, IKBKB, STAT3, MAPK3, VEGFA, RAC2, VEGFB, RALA, ARAF",0.31695296176115,0.11747546204512,FALSE
+"H1299","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41051,-1.5,0.0674,17871,0.281,"PANK2, PANK1, PPCS",1.17134010346468,0.55129368009492,FALSE
+"H1299","Input","KEGG_PARKINSONS_DISEASE",0.29047,0.991,0.429,3628,1,"COX7B2, COX8C, LRRK2, NDUFB9, UQCRFS1, NDUFA9, CYC1, UCHL1, SLC25A31, SDHB, HTRA2, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, ATP5F1B, UBE2G1, GPR37, COX8A, UBE2J2, NDUFS6, NDUFV2, SLC25A6, COX6C, PARK7, NDUFB1, UBB",0.367542707815276,0,FALSE
+"H1299","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.20995,0.716,0.842,4841,1,"ARPC1A, TUBB3, YWHAQ, NCL, YWHAZ, ARPC1B, TUBB6, EZR, TUBB4B, TUBA1C, ACTG1, TUBB, OCLN, TUBB4A, TUBA1A, TUBB2B, ARPC5L, ARHGEF2, RHOA, TUBA1B, TUBB2A",0.0746879085003505,0,FALSE
+"H1299","Input","KEGG_PATHWAYS_IN_CANCER",-0.27059,-0.993,0.405,16579,0.684,"TGFBR1, PLCG2, CHUK, GSK3B, PDGFRB, LAMA4, BCR, FN1, WNT11, ERBB2, RASSF5, COL4A6, LAMA1, LAMC1, BMP2, PPARG, ELOB, CBLC, PTGS2, IGF1R, CUL2, CTNNA1, DAPK2, SUFU, SLC2A1, PPARD, FGFR3, IL6, FGF13, EGF, STAT1, CASP8, FH, IKBKB, CDH1, LAMB1, MITF, MMP2, FGFR2, HIF1A, GLI2, BMP4, ARNT2, WNT5A, LAMA3, STAT3, XIAP, RXRA, EP300, CXCL8, MAPK3, WNT7B, EGLN3, FADD, VEGFA, FOXO1, RAC2, CBLB, KITLG, TRAF4, FLT3LG, VEGFB, COL4A1, NCOA4, EPAS1, STAT5A, DAPK1, RARA, COL4A2, PDGFA, TRAF6, RALA, JUP, STAT5B, ARAF",0.392544976785331,0.164943898279884,FALSE
+"H1299","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.32055,-1.15,0.218,9885,0.557,"UGT2B11, UGT2B17, UGT2B4, UGDH, AKR1B1, UGP2, UGT2A1, UGT2A3, UGT2B15, CRYL1, UGT2B7, DCXR, DHDH",0.661543506395395,0.254144804826271,FALSE
+"H1299","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.32056,-1.16,0.216,16980,0.56,"PGM1, H6PD, RBKS, TKT, G6PD, TALDO1, ALDOC",0.665546248849069,0.2518119729938,FALSE
+"H1299","Input","KEGG_PEROXISOME",-0.24,-0.877,0.592,14162,0.774,"PEX11B, SLC25A17, PXMP2, SLC27A2, EHHADH, ACSL1, PHYH, ACOX1, ACAA1, PEX11A, FAR1, PEX6, HMGCL, PIPOX, DDO, MVK, MPV17L, PRDX5, ABCD3, ACSL5, SCP2, IDH1, CAT, PEX12, NUDT12, DHRS4, IDH2",0.22767829327708,0.111259039317107,FALSE
+"H1299","Input","KEGG_PHENYLALANINE_METABOLISM",-0.4242,-1.53,0.0597,11410,0.297,"TAT, AOC3, PAH, AOC2, DDC, MAOA, IL4I1, PRDX6, MAOB, ALDH3B2, ALDH1A3, ALDH3A1",1.22402566887063,0.527243550682788,FALSE
+"H1299","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.1855,0.629,0.96,4331,1,"PIK3CG, IMPA1, PLCD4, INPP5E, CALM1, PIKFYVE, PLCB4, PIK3CB, DGKE, PRKCG, ITPR2, ITPKA, PIK3CD, DGKD, CALM3, INPP5K, SYNJ2, SYNJ1",0.0177287669604316,0,FALSE
+"H1299","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.40441,-1.49,0.0501,14919,0.27,"BLVRA, UGT2B7, HMBS, EARS2, HMOX2, COX15, CP, MMAB, UROS, FTH1",1.30016227413275,0.568636235841013,FALSE
+"H1299","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2951,-1.09,0.291,14313,0.6,"CPT2, CPT1B, SLC27A2, EHHADH, FABP3, AQP7, ACSL1, NR1H3, ACOX1, ACAA1, LPL, CD36, PCK2, OLR1, UBC, PLIN1, PDPK1, PPARG, FADS2, CYP27A1, PPARD, CPT1C, FABP6, ACSL5, SCP2, ME1, PPARA, SORBS1, RXRA",0.536107011014093,0.221848749616356,FALSE
+"H1299","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.27212,-0.994,0.398,13901,0.691,"CH25H, HSD17B4, CYP7B1, CYP27A1, HSD3B7, SCP2",0.400116927926312,0.160521952625802,FALSE
+"H1299","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.16392,0.56,0.981,15984,1,"CD40, TAP2, CD19, UNG, TAP1, RFX5, RFXANK, TNFRSF13C, BTK, JAK3, ADA, ZAP70, RAG2, TNFRSF13B, CD40LG, CD8B, ICOS, CD3E, CD4, AICDA, AIRE, RFXAP, RAG1, DCLRE1C, PTPRC, CD3D, CD79A, CIITA, IGLL1, LCK, IL2RG, IL7R, IKBKG, BLNK, CD8A",0.0083309926200515,0,FALSE
+"H1299","Input","KEGG_PRION_DISEASES",-0.31305,-1.15,0.255,16130,0.557,"IL1A, CCL5, IL1B, PRKACB, NOTCH1, NCAM1, LAMC1, IL6, MAPK3",0.593459819566045,0.254144804826271,FALSE
+"H1299","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.3711,1.26,0.178,3712,0.691,"PIK3CG, HSP90AA1, CCNA1, BUB1, ANAPC4, CCNB1, CPEB1, HSP90AB1, ANAPC13, PLK1, MAD2L2, CCNB2, MAPK11, AKT1, MAPK12, PIK3CB, CDC25C, CDC25A, ANAPC1, CCNA2, PDE3B, AKT2, FZR1, PIK3CD, ANAPC7, ANAPC5, GNAI2",0.749579997691106,0.160521952625802,FALSE
+"H1299","Input","KEGG_PROPANOATE_METABOLISM",-0.46552,-1.64,0.0543,14291,0.281,"ECHS1, EHHADH, ACACA, HIBCH, ACSS3, LDHA, SUCLA2, ABAT, ALDH6A1, ALDH2, PCCA, ACSS1, MCEE",1.26520017041115,0.55129368009492,FALSE
+"H1299","Input","KEGG_PROSTATE_CANCER",-0.23597,-0.864,0.622,15482,0.786,"PDGFRA, MDM2, CCNE1, CREBBP, IKBKG, AR, SOS2, CHUK, GSK3B, PDGFRB, ERBB2, PDPK1, IGF1R, EGF, CREB3L2, IKBKB, FGFR2, EP300, MAPK3, FOXO1, PDGFA, ARAF",0.206209615309181,0.104577453960592,FALSE
+"H1299","Input","KEGG_PROTEASOME",0.39336,1.35,0.14,2638,0.589,"PSMB1, PSMC4, PSMB7, PSMD8, PSMC1, PSMB6, PSMC5, PSMD7, PSMD4, PSMD14, PSMD1, SEM1",0.853871964321762,0.229884705212898,FALSE
+"H1299","Input","KEGG_PROTEIN_EXPORT",-0.55924,-2.01,0.0165,15585,0.31,"SEC61B, SEC62, IMMP1L, SRP9, SRP54, SEC61G, OXA1L, SRP72, SPCS2",1.78251605578609,0.508638306165727,FALSE
+"H1299","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.43501,-1.59,0.0497,13639,0.286,"ATP1B2, ATP1A2, FXYD2, GLS2, GLUD2, PCK2, AQP1, GLS, SLC38A3, ATP1A1, SLC4A4, MDH1",1.30364361126667,0.543633966870957,FALSE
+"H1299","Input","KEGG_PURINE_METABOLISM",0.28487,0.96,0.442,3713,1,"AK5, POLR2D, NPR2, NME2, APRT, NT5E, AK4, POLR1E, POLA1, PRIM1, POLR3G, NME6, PFAS, PDE6D, PDE4A, PDE4C, POLR2I, POLR2A, POLE3, ENTPD5, AMPD2, POLE2, GMPS, NT5M, IMPDH2, NME1, POLR2K, POLD1, PDE3B, POLE, RRM2, PDE6B, RRM2B, GART, PRIM2, NUDT2, NME4, PNPT1, POLR2J, POLR2E",0.354577730650908,0,FALSE
+"H1299","Input","KEGG_PYRIMIDINE_METABOLISM",0.37526,1.29,0.151,4271,0.653,"POLR2D, DHODH, NME2, DTYMK, NT5E, POLR1E, POLA1, PRIM1, POLR3G, TYMS, NME6, POLR2I, POLR2A, DUT, POLE3, ENTPD5, POLE2, CAD, NT5M, NME1, POLR2K, POLD1, POLE, UMPS, RRM2, RRM2B, PRIM2, NUDT2, NME4, PNPT1, POLR2J, POLR2E, TXNRD2, UCK2, POLR3H, POLR1C, CTPS1",0.821023052706831,0.185086818724926,FALSE
+"H1299","Input","KEGG_PYRUVATE_METABOLISM",-0.27126,-0.985,0.44,17768,0.691,"HAGH, MDH1, ME1, PC, ALDH2, ACSS1",0.356547323513813,0.160521952625802,FALSE
+"H1299","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.16551,0.564,0.988,4043,1,"PIK3CG, ITGAM, PAK4, ITGA4, ITGA10, PXN, PFN1, ARPC1A, FGF5, MYLK2, ITGA6, FGF12, PIKFYVE, PAK2, F2R, BCAR1, APC2, MAP2K2, ARPC1B, PIK3CB, PTK2, TIAM1, FGF11, CRK, EZR, PPP1CC, WASF1, RAC3, RRAS, PPP1R12A, MYH10, MYL9, PIK3CD, FGF1, NRAS, ACTG1, VCL, MYL12A, CFL2, FGD1, FGFR1, ITGA2, MYL12B, WASF2",0.00524305541237188,0,FALSE
+"H1299","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.26931,0.923,0.523,4083,1,"IFNA13, PIK3R4, ATG7, ATG12, GABARAPL2, ATG5, ATG4B, ULK3",0.281498311132726,0,FALSE
+"H1299","Input","KEGG_RENAL_CELL_CARCINOMA",-0.31509,-1.13,0.278,17178,0.562,"ELOB, CUL2, SLC2A1, PAK6, FH, HIF1A, ARNT2, EP300, RAP1A, GAB1, MAPK3, EGLN3, VEGFA, VEGFB, EPAS1, ARAF",0.555955204081924,0.250263684430939,FALSE
+"H1299","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.31974,1.09,0.299,4412,0.989,"THOP1, MME, ANPEP, ENPEP, NLN",0.52432881167557,0.0048037084028206,FALSE
+"H1299","Input","KEGG_RETINOL_METABOLISM",-0.28171,-1.03,0.364,11816,0.664,"CYP2C19, UGT2B15, CYP2A7, CYP2C9, RPE65, CYP26C1, CYP2B6, CYP26A1, CYP3A4, CYP4A22, ADH1C, CYP2C18, DHRS3, CYP2A6, PNPLA4, CYP3A7, UGT2B7, CYP1A1, DHRS9, BCO1, RETSAT, RDH12, RDH16, CYP3A5, ALDH1A1, CYP26B1, DHRS4, DHRS4L2",0.438898616350944,0.177831920631982,FALSE
+"H1299","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.51304,-1.92,0.0113,13276,0.282,"ENPP3, ACP4, MTMR7, FLAD1, ACP1, ACP5, ACP2, ACP6, MTMR6",1.94692155651658,0.549750891680639,FALSE
+"H1299","Input","KEGG_RIBOSOME",0.33746,1.14,0.25,5670,0.871,"RPS20, RPL7, RPL13, RPS12, RPS16, RPL26L1, RPL8, RPL35A, RPL30, RPS4X, RPS10, RPSA, RPS19, RPS28, RPL18A, RPS15, UBA52, RPL9, RPL22, RPL29, RPL17, RPL11, MRPL13, RPL35, RPL14, RPS26, RPL41, RPL6, RPL31, RPL5, RPS21, RPS6, RPL3, RPS23, RPS7, RPLP0, RPS27A, RPL4, RPL38, RPL32, RPL37A, RPS9, RPL34, RPL26, RPS25",0.602059991327962,0.0599818449923368,FALSE
+"H1299","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.2561,-0.921,0.546,16349,0.75,"DDX3Y, CYLD, OTUD5, CHUK, MAPK13, CASP8, IKBKB, MAVS, CXCL8, IKBKE, FADD, DHX58, CASP10, MAP3K1, TRAF6",0.262807357295263,0.1249387366083,FALSE
+"H1299","Input","KEGG_RNA_DEGRADATION",0.38539,1.31,0.164,5451,0.645,"HSPD1, PAPOLA, SKIV2L, LSM7, EDC4, LSM2, DCP2, EXOSC10, EXOSC3, EXOSC5, EXOSC2, ENO1, CNOT9, CNOT7, PNPT1, EXOSC4, HSPA9, LSM3, CNOT3, LSM6, MTREX, ZCCHC7, MPHOSPH6, DCP1B, LSM4, LSM1, EXOSC7, EXOSC6",0.785156151952302,0.190440285364732,FALSE
+"H1299","Input","KEGG_RNA_POLYMERASE",0.40475,1.37,0.114,4238,0.585,"POLR2D, POLR1E, POLR3G, POLR2I, POLR2A, POLR2K, POLR2J, POLR2E, POLR3H, POLR1C",0.943095148663527,0.23284413391782,FALSE
+"H1299","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.31319,-1.13,0.237,14276,0.562,"GGT6, GGT5, MAT1A, HEMK1, CTH, LCMT1, GGT1, LCMT2, AHCYL1",0.625251653989896,0.250263684430939,FALSE
+"H1299","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.21331,0.718,0.845,3546,1,"PIK3CG, LAMC3, TRAF3, BIRC3, PIAS3, ITGA6, TRAF1, E2F2, AKT1, CDKN2B, PIK3CB, E2F3, PTK2, CDK6, CKS1B, AKT2, TRAF2, PIAS4, PIK3CD, NFKB1",0.0731432910503077,0,FALSE
+"H1299","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.35173,-1.3,0.145,15917,0.37,"STX3, STX19, SNAP23, BNIP1, STX17, SEC22B, SNAP47, GOSR2, STX12, GOSR1, VAMP8, VAMP5, BET1L, STX6",0.838631997765025,0.431798275933005,FALSE
+"H1299","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2691,-0.999,0.413,14043,0.701,"NEU4, GLA, KDSR, DEGS2, GAL3ST1, SGPP2, SMPD1, DEGS1, GBA, ACER3, PLPP3, GLB1, SGPL1, ARSA, ASAH1",0.384049948343599,0.154281982033341,FALSE
+"H1299","Input","KEGG_SPLICEOSOME",0.49538,1.68,0.0364,4233,0.415,"SNRPD2, SF3B5, SNRPC, BUD31, DHX16, DHX38, MAGOHB, HSPA1L, HSPA8, PUF60, WBP11, SNW1, RBM8A, HNRNPA1, SART1, HSPA1A, LSM7, ALYREF, HSPA1B, CTNNBL1, U2SURP, PRPF8, PRPF6, DDX39B, LSM2, XAB2, HNRNPM, RBM22, SNRPF, CDC40, PRPF31, TRA2B, HNRNPU, RBM25, SNRNP200, TCERG1, SF3B4, SRSF9, DHX15, SNRNP40, SYF2, ISY1, SNRPA, SNRPG, SNRPB, PPIL1, HNRNPK, DDX23, SF3A1, SF3A3, SF3A2, PRPF4, TXNL4A, SRSF1, HNRNPA3, CDC5L, LSM3, HSPA2, SNRPA1, U2AF1",1.43889861635094,0.381951903287907,FALSE
+"H1299","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.17176,-0.633,0.965,9337,0.969,"UGT2B10, SI, AMY2B, UGT2B11, GBA3, UGT2B17, AMY1C, AMY1A, UGT2B4, UGDH, HK3, GAA, GBE1, UGP2, G6PC2, UGT2A1, UGT2A3, UGT2B15, MGAM, ENPP3, PYGM, TREH, HK2, UXS1, PGM2L1, UGT2B7, AGL, PGM1, GYS1, HK1",0.0154726866562074,0.0136762229492347,FALSE
+"H1299","Input","KEGG_STEROID_BIOSYNTHESIS",-0.58004,-2.11,0.0028,15796,0.565,"DHCR7, NSDHL, DHCR24, LIPA, SC5D, MSMO1",2.55284196865778,0.247951552180562,FALSE
+"H1299","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.30917,-1.14,0.241,14742,0.566,"AKR1C2, CYP3A7, CYP19A1, SRD5A1, UGT2B7, CYP1A1, CYP7B1, HSD17B2, CYP3A5, HSD11B2, SRD5A3, STS, AKR1C1, HSD17B12, AKR1C3",0.617982957425132,0.247183568811729,FALSE
+"H1299","Input","KEGG_SULFUR_METABOLISM",-0.35104,-1.31,0.131,16556,0.375,"SULT1A2, BPNT1, SULT1A1",0.882728704344236,0.425968732272281,FALSE
+"H1299","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.26652,-0.967,0.441,11568,0.713,"IL10, C5, FCGR2B, FCGR2C, ACTN2, C6, CD86, CTSG, GRIN2A, SNRPD3, TNF, FCGR1A, ELANE, FCGR2A, C2, SNRPD1, C3, TRIM21, C1S, C1R",0.355561410532161,0.146910470148134,FALSE
+"H1299","Input","KEGG_TASTE_TRANSDUCTION",0.46914,1.62,0.0578,2683,0.395,"CACNA1A, SCNN1G, CACNA1B, TAS2R43, TAS2R8, SCNN1B, TAS2R14, TAS2R40, TAS2R46, TAS2R50, TAS2R19, GNB3, TAS2R20, TAS2R10",1.23807216157947,0.40340290437354,FALSE
+"H1299","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.40719,1.41,0.0863,1279,0.64,"CDO1, GAD1",1.06398920428479,0.193820026016113,FALSE
+"H1299","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.34964,-1.28,0.156,16796,0.381,"MVK, HMGCS1, GGPS1",0.806875401645538,0.419075024324381,FALSE
+"H1299","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.19662,-0.737,0.884,14662,0.969,"THBS2, CHRD, PPP2R1A, TNF, BMPR1A, RBL2, ACVRL1, CREBBP, RPS6KB2, THBS1, TGFBR1, INHBE, INHBB, BMP2, SMAD7, TFDP1, SKP1, INHBA, SMAD6, LTBP1, FST, BMP4, EP300, MAPK3, SMAD5",0.0535477349869269,0.0136762229492347,FALSE
+"H1299","Input","KEGG_THYROID_CANCER",-0.35324,-1.32,0.114,17134,0.379,"PPARG, CDH1, RXRA, MAPK3, NCOA4",0.943095148663527,0.421360790031928,FALSE
+"H1299","Input","KEGG_TIGHT_JUNCTION",0.18362,0.634,0.952,4356,1,"MYH15, PARD6A, CSNK2B, CLDN20, PPP2R2C, JAM3, AKT1, YBX3, RAB3B, PRKCG, CLDN15, EPB41L2, MPDZ, SYMPK, AKT2, RRAS, LLGL1, MYH10, MYL9, TJAP1, SPTAN1, MYH3, NRAS, ACTG1, CGN, MYL12A, GNAI2, PRKCZ, OCLN, MYL12B, PRKCE, AFDN, MAGI1",0.0213630516155257,0,FALSE
+"H1299","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29954,-1.1,0.293,16314,0.602,"CCL5, IL1B, TAB1, CHUK, TLR2, LY96, TLR4, TLR1, IRF5, MAPK13, IL6, TLR5, TIRAP, STAT1, CASP8, IKBKB, TOLLIP, TICAM2, MAP2K6, TLR3, CXCL8, MAPK3, IKBKE, FADD, MAP3K8, TRAF6, MYD88",0.533132379645891,0.220403508742175,FALSE
+"H1299","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.43404,-1.62,0.0245,12346,0.269,"INMT, GCDH, CYP1B1, WARS2, ACMSD, DDC, MAOA, AANAT, ECHS1, AOC1, AADAT, EHHADH, IL4I1, IDO1, HAAO, KMO, MAOB, CYP1A1, HADH, TDO2, KYNU, CAT, ALDH2",1.61083391563547,0.570247719997592,FALSE
+"H1299","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29037,1.01,0.391,403,1,"PIK3CG, CACNA1A, GCK, CACNA1B",0.407823242604133,0,FALSE
+"H1299","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.25106,0.838,0.654,1279,1,"HSPD1, GAD1",0.184422251675733,0,FALSE
+"H1299","Input","KEGG_TYROSINE_METABOLISM",-0.2501,-0.906,0.55,11110,0.764,"DBH, DCT, TAT, AOC3, COMT, TYR, AOC2, TPO, DDC, MAOA, ADH1C, TH, IL4I1, TYRP1, HEMK1, MAOB, ALDH3B2, HGD, GSTZ1, LCMT1, ALDH1A3, ALDH3A1, LCMT2",0.259637310505756,0.11690664142431,FALSE
+"H1299","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.19907,0.697,0.897,2189,1,"PIK3CG, MAP3K14, PAK4, NFKBIB, FOS, PAK2, MAP3K7, MAPK11, AKT1, MAP2K2, MAPK12, NFKBIE, PIK3CB",0.0472075569559079,0,FALSE
+"H1299","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.28473,-1.06,0.363,16976,0.632,"CDC16, TRIM32, KLHL9, FBXW8, UBOX5, ELOB, CBLC, CUL2, SKP1, ANAPC10, MGRN1, SIAH1, BTRC, UBE2I, XIAP, UBE2F, UBE2H, MID1, SYVN1, DET1, UBE2A, UBE2L6, CBLB, MAP3K1, UBA7, FBXW7, TRAF6, COP1, UBE2E1",0.440093374963888,0.199282921717615,FALSE
+"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.62788,2.18,0,4488,0.248,"VARS2, PDHB, BCAT1, PDHA1",Inf,0.605548319173784,TRUE
+"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.43423,-1.57,0.0503,14291,0.293,"ECHS1, EHHADH, IL4I1, DBT, HIBCH, ACAA1, HADHB, HMGCL, OXCT1, MCCC1, HADH, HMGCS1, ABAT, ALDH6A1, ALDH2, PCCA, MCEE, HIBADH",1.29843201494407,0.533132379645891,FALSE
+"H1299","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.19437,-0.719,0.871,14244,0.97,"ADRA1D, EDNRA, PRKCA, MYLK3, GUCY1A1, ITPR3, CALCRL, PLA2G10, MYL6, CACNA1D, PRKCH, ADCY4, ACTG2, CACNA1C, ADCY9, ITPR1, PRKCD, ADCY5, GNAQ, PRKACB, PPP1R12B, ADCY6, ADCY1, RAMP2, PLCB2, RAMP1, ADCY7, PLA2G4A, MAPK3, PLA2G12A, PPP1CB, ARAF",0.0599818449923368,0.0132282657337552,FALSE
+"H1299","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.32427,-1.2,0.215,16749,0.498,"PRKACB, ADCY6, ARHGDIB, RAB5A, AQP3, CREB3L2, RAB5B, DYNLL2, DCTN5, DCTN6, RAB5C",0.667561540084395,0.302770657240282,FALSE
+"H1299","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.20612,-0.754,0.814,16606,0.956,"PLCG2, SRC, NFATC2, PTGS2, MAPK13, PLA2G4A, MAPK3, VEGFA, RAC2, PLA2G12A, MAPKAPK2, PPP3CB",0.0893755951107988,0.0195421077238999,FALSE
+"H1299","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.35939,-1.34,0.108,12681,0.362,"MUC2, CFTR, ATP6V0D1, ATP6V1G3, KCNQ1, PDIA4, ATP6V0D2, PRKCA, ATP6V1C2, ACTB, SLC12A2, ATP6V0A1, SEC61B, ADCY9, ATP6V1E1, ERO1A, ATP6V1A, ATP6V0A4, ATP6V1B2, ATP6V1G2, PLCG2, PRKACB, TJP2, ATP6V1B1, ATP6AP1, SEC61G, ATP6V0E1, KDELR2, ARF1",0.96657624451305,0.441291429466834,FALSE
+"H1299","Input","KEGG_VIRAL_MYOCARDITIS",0.14034,0.486,0.994,3926,0.998,"MYH15, CD40, ICAM1, RAC3, MYH10, MYH3, ACTG1, EIF4G3, EIF4G1",0.00261361560268669,0.000869458712628891,FALSE
+"H1299","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.19241,-0.697,0.902,14778,0.957,"PPP2R1A, NKD1, FZD4, APC, WNT10A, WNT4, WNT7A, CREBBP, RAC1, CAMK2B, DAAM2, CTBP2, DVL3, MMP7, GSK3B, PRKACB, NFATC2, WNT11, LRP5, FRAT1, PORCN, PPARD, PLCB2, SKP1, NLK, PRICKLE2, WNT5A, VANGL2, SIAH1, BTRC, EP300, WNT7B, FRAT2, TBL1XR1, RAC2, DAAM1, PPP3CB",0.0447934624580583,0.0190880622231565,FALSE
+"HCC44","Input","KEGG_ABC_TRANSPORTERS",-0.14437,-0.417,1,10995,0.999,"ABCC6, ABCB4, ABCA13, ABCB1, ABCG4, ABCA12, ABCD3, ABCA2, ABCB8, ABCC10, ABCB6, ABCB10, ABCD4, ABCB9",0,0.000434511774017692,FALSE
+"HCC44","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.39866,-1.16,0.222,14933,0.504,"MAPK1, LEF1, EIF4EBP1, PIK3CA, RPS6KB1, PIM1, TCF7L1, GRB2, KRAS, RELA, IKBKB, PML, SOS1, RPS6KB2, HRAS, MAPK3, PIK3R2, BAD",0.653647025549361,0.297569463554475,FALSE
+"HCC44","Input","KEGG_ADHERENS_JUNCTION",-0.26087,-0.761,0.867,12186,1,"WASL, TCF7L2, NECTIN1, CSNK2A1, SSX2IP, PARD3, RAC3, CREBBP, RHOA, INSR, IQGAP1, LMO7, ACP1, SORBS1, CDC42, MAPK1, LEF1, WASF2, CTNND1, TCF7L1, WASF3, FARP2, PTPN1, ERBB2, SRC, MAPK3",0.0619809025237897,0,FALSE
+"HCC44","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.26187,-0.77,0.838,11172,1,"PRKAB2, PRKAB1, TNFRSF1B, SLC2A4, MTOR, AKT2, PTPN11, PPARA, STK11, PRKCQ, AKT1, ACACB, RXRA, PPARGC1A, MAPK10, CPT1C, NFKBIE, ACSL3, MAPK9, CAMKK1, TRADD, CAMKK2, ADIPOR1, RXRB, RELA, IKBKB, CPT1B, ACSL1, PRKAG1",0.0767559813697235,0,FALSE
+"HCC44","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.23418,-0.679,0.934,14681,1,"GPT, GFPT1, CPS1, ABAT, ALDH5A1, GLUL, NIT2, GOT1",0.0296531237699066,0,FALSE
+"HCC44","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.27633,-0.801,0.808,8977,1,"PIK3CG, FXYD2, NEDD4L, PIK3R5, IGF1, HSD11B1, SCNN1G, ATP1B2, PIK3CD, KCNJ1, SCNN1A, PRKCA, SCNN1B, PIK3CB, PRKCG, PIK3R3, INSR, NR3C2, PIK3R1, MAPK1, PDPK1, PIK3CA, KRAS, MAPK3, PIK3R2",0.0925886392254138,0,FALSE
+"HCC44","Input","KEGG_ALLOGRAFT_REJECTION",0.53632,2.07,0,362,0.0756,"TNF, IL2, IL12B",Inf,1.12147820449879,TRUE
+"HCC44","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.56047,-1.64,0.0137,17652,0.11,"PLA2G4B, PLA2G6, ACOX1, PLA2G12A",1.86327943284359,0.958607314841775,TRUE
+"HCC44","Input","KEGG_ALZHEIMERS_DISEASE",-0.57556,-1.68,0.00636,15313,0.106,"GAPDH, LRP1, NDUFB2, PPP3CB, PPP3CC, PSEN2, UQCRC1, SDHB, APBB1, IDE, NDUFA9, ADAM10, NDUFS4, COX7B, NDUFV2, ATP5PF, GSK3B, NDUFS5, CASP3, NDUFA3, ATP5PB, NDUFB9, SDHD, SDHC, FADD, COX6B1, COX7A2L, UQCRQ, CALM2, UQCRFS1, APH1A, UQCRC2, CYC1, NDUFB7, CHP1, NDUFB1, UQCR11, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, GNAQ, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, HSD17B10, NDUFV1, CDK5, NDUFB8, NDUFB4, NDUFC2, ATP5F1C, MAPK3, CALM3, CAPN1, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, PLCB3, NDUFA2, NDUFS3, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, BAD, COX8A, NDUFB3",2.19654288435159,0.97469413473523,TRUE
+"HCC44","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.50591,-1.47,0.0467,13716,0.196,"VARS2, EARS2, CARS2, TARS2, DARS2, FARS2, PARS2, IARS2, AARS2, SEPSECS, HARS2, MTFMT, NARS2",1.33068311943389,0.707743928643524,TRUE
+"HCC44","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.47665,-1.41,0.0612,14409,0.249,"NPL, CMAS, GNE, GALK1, GPI, GFPT1, UXS1, CYB5R3, GMPPB, CYB5R1, GNPDA1, GALK2, AMDHD2, NAGK, PMM1, UGP2, GMPPA, MPI, GALT, FPGT",1.21324857785444,0.603800652904264,FALSE
+"HCC44","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.40414,-1.18,0.217,14202,0.501,"MAPK14, DERL1, ALS2, BCL2L1, BAX, PPP3CB, PPP3CC, DAXX, TOMM40L, CAT, CASP3, MAP2K6, SOD1, CHP1, MAPK11, TP53, APAF1, CCS, BAD",0.66354026615147,0.300162274132754,FALSE
+"HCC44","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.29309,1.09,0.25,1630,0.69,"KLRC2, CD74, HSPA6, KLRC3, HSPA1B, HSPA5, HSPA1A, IFNA1, PSME1, TAPBP, TAP2, LGMN",0.602059991327962,0.161150909262745,FALSE
+"HCC44","Input","KEGG_APOPTOSIS",-0.27951,-0.818,0.799,14098,1,"PRKACA, PIK3R1, FAS, AIFM1, BCL2L1, PRKAR1A, BAX, PPP3CB, PPP3CC, PRKAR2B, TRADD, PIK3CA, CASP3, IRAK4, FADD, RELA, IKBKB, CHP1, ENDOG, PRKX, CASP6, TP53, PIK3R2, CAPN1, APAF1, BAD",0.0974532206860086,0,FALSE
+"HCC44","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.17975,-0.521,0.992,17627,1,"PTGES2, PLA2G4B, LTA4H, PLA2G6, PLA2G12A",0.00348832784582135,0,FALSE
+"HCC44","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.29107,-0.843,0.756,11735,1,"GLUD1, GLUD2, GOT2, PYCR1, P4HA1, GLS2, ALDH18A1, GATM, ALDH7A1, CKMT1A, CKMT1B, PRODH, NOS3, SAT2, LAP3, CPS1, SMS, PYCR2, OAT, ALDH9A1, GLUL, AZIN2, GOT1, GAMT, PYCR3",0.121478204498793,0,FALSE
+"HCC44","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.20439,-0.607,0.976,9327,1,"LAMA2, SGCG, CACNA2D3, ITGA11, SGCB, CTNNA2, CTNNA1, SGCD, SGCA, CACNG7, ITGA10, CACNA1C, CACNB2, ITGA9, ACTN2, CACNA2D2, ITGA6, RYR2, DAG1, CACNG6, TCF7L2, CACNA1D, CACNB4, CACNG8, ITGA4, ITGB6, ITGA2B, SLC8A1, LMNA, CACNG4, LEF1, ITGA7, CACNA2D1, PKP2, DMD, ITGB8, EMD, CDH2, TCF7L1, CACNB3",0.0105501823333082,0,FALSE
+"HCC44","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.15866,-0.459,1,16830,1,"ALDH9A1",0,0,FALSE
+"HCC44","Input","KEGG_ASTHMA",0.44335,1.61,0.0678,2492,0.241,"TNF, IL13, CD40, PRG2, FCER1A",1.16877030613294,0.617982957425132,FALSE
+"HCC44","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.33423,1.24,0.188,9163,0.481,"IL2, IFNA1, CD40, IFNA4, IFNA17, IFNA6, IFNA16, CD28, FASLG, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, CD80, IL10, TSHB, IFNA13, IL4, CTLA4, CD86, IFNA21, CGA, PRF1, IFNA8, GZMB, TPO, IFNA5, TSHR",0.72584215073632,0.317854923626168,FALSE
+"HCC44","Input","KEGG_AXON_GUIDANCE",-0.3119,-0.905,0.626,11084,1,"EPHB1, NRAS, CXCL12, ROBO2, PLXNB1, GNAI2, EPHA3, NTN1, DPYSL5, ABLIM2, SEMA3C, EPHA6, SEMA6D, UNC5A, ARHGEF12, UNC5B, NGEF, ROBO1, FES, SLIT3, SEMA6A, EFNA2, RAC3, RHOA, EPHB4, SLIT2, CXCR4, SEMA3D, NFATC3, SEMA4A, SEMA3E, PLXNB2, EFNB3, PLXNB3, PTK2, SEMA5A, GNAI3, PAK4, EPHA1, ROBO3, CDC42, SEMA6C, MAPK1, RASA1, PAK6, NFATC4, EFNB1, PPP3CB, SEMA4D, PPP3CC, SEMA4C, SRGAP3, SEMA4G, DPYSL2, EPHA4, EPHB3, GSK3B, PAK1, EFNA4, RGS3, KRAS, LIMK2, EFNA3, CHP1, NCK2, SEMA4F, CFL1, CDK5, HRAS, MAPK3, SRGAP2",0.20342566678957,0,FALSE
+"HCC44","Input","KEGG_BASAL_CELL_CARCINOMA",-0.29998,-0.885,0.654,12191,1,"HHIP, FZD8, WNT4, TCF7L2, PTCH1, FZD3, WNT10A, FZD7, AXIN2, WNT10B, GLI1, BMP4, FZD4, LEF1, DVL3, APC, FZD2, GSK3B, AXIN1, STK36, TCF7L1, DVL2, SMO, SUFU, TP53",0.184422251675733,0,FALSE
+"HCC44","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.40519,-1.18,0.203,13676,0.501,"TBPL1, GTF2E1, TAF11, TAF2, TAF7, TAF9B, STON1, GTF2E2, GTF2B, TAF6, TAF10, TAF1, TAF6L, TAF5, GTF2A2",0.692503962086787,0.300162274132754,FALSE
+"HCC44","Input","KEGG_BASE_EXCISION_REPAIR",-0.57625,-1.69,0.0128,12329,0.115,"NEIL1, XRCC1, APEX1, PARP2, POLD1, POLE, PCNA, LIG3, POLE4, MUTYH, FEN1, PARP3, APEX2, POLD3, SMUG1, POLD4, MPG, NEIL3, UNG, LIG1, POLL, NEIL2, OGG1, NTHL1, POLB",1.89279003035213,0.939302159646388,TRUE
+"HCC44","Input","KEGG_BETA_ALANINE_METABOLISM",-0.40672,-1.18,0.213,15448,0.501,"ABAT, SMS, HADHA, EHHADH, ALDH9A1, ECHS1, HIBCH",0.671620396561262,0.300162274132754,FALSE
+"HCC44","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.44375,-1.31,0.0985,13525,0.353,"HSD17B12, ELOVL2, HACD2, ACOT7, TECR, ACAA1, HADHA, SCD5, ACOX1, PECR",1.00656376950239,0.452225294612177,FALSE
+"HCC44","Input","KEGG_BLADDER_CANCER",-0.31503,-0.927,0.58,14933,0.975,"MAPK1, CDK4, DAPK1, MDM2, KRAS, E2F1, E2F2, ERBB2, HRAS, TP53, MAPK3, VEGFB",0.236572006437063,0.0109953843014632,FALSE
+"HCC44","Input","KEGG_BUTANOATE_METABOLISM",-0.49672,-1.44,0.0547,12914,0.223,"L2HGDH, BDH2, ALDH7A1, AACS, ACAT2, ABAT, ALDH5A1, HADHA, EHHADH, HMGCL, ALDH9A1, HMGCS1, PDHB, ECHS1, ACADS, HADH, PDHA1, ACAT1",1.26201267366657,0.651695136951839,FALSE
+"HCC44","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31521,-0.92,0.609,11376,0.975,"PIK3CB, CD81, BLNK, BCL10, VAV2, MAP2K1, AKT2, INPP5D, PIK3R3, RAC3, SOS2, IFITM1, AKT1, NFATC3, SYK, PIK3AP1, PIK3R1, LILRB3, MAPK1, VAV3, CD72, NFATC4, NFKBIE, PPP3CB, PPP3CC, PLCG2, PIK3CA, GSK3B, GRB2, KRAS, RELA, IKBKB, CHP1, SOS1, HRAS, MAPK3, PIK3R2",0.215382707367125,0.0109953843014632,FALSE
+"HCC44","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.19988,-0.579,0.981,12473,1,"F2R, P2RX6, PDE1C, PRKCG, PLCD4, CAMK2B, RYR1, ATP2A1, CACNA1D, CACNA1H, PDGFRB, TBXA2R, CALML6, ADRA1B, TNNC1, CHRM3, PRKACA, CALM1, SLC8A1, CHRNA7, VDAC1, PLCB4, NOS3, GNA11, CAMK4, PHKB, GNAL, ERBB3, PPID, ITPKA, P2RX4, PHKG2, PPP3CB, PPP3CC, PLCG2, CAMK2D, ITPKB, VDAC2, ADCY9, SLC25A4, PHKA2, CAMK2G, CALM2, SLC25A6, CHP1, ERBB2, PLCD1, PLCG1, GNAQ, PRKX, SPHK2, VDAC3, CALM3, PLCB3",0.0083309926200515,0,FALSE
+"HCC44","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.44629,-1.29,0.116,13704,0.362,"TNNC1, CACNB4, CACNG8, UQCRH, COX7A2, SLC8A1, TNNI3, CACNG4, CACNA2D1, UQCRC1, COX7B, SLC9A6, TPM3, COX6B1, COX7A2L, UQCRQ, UQCRFS1, UQCRC2, CYC1, UQCR11, UQCRHL, COX5A, COX7C, UQCR10, COX6A1, CACNB3, COX5B, COX6C, UQCRB, COX8A",0.935542010773082,0.441291429466834,FALSE
+"HCC44","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.18511,0.695,0.92,1943,0.978,"ITGB2, CD274, PVR, ICAM1, PDCD1LG2, ICAM2, SELPLG, CLDN1, PTPRF, CD58, NEGR1, SDC4, ITGAV, ALCAM, ITGB1, CD40, CLDN4",0.0362121726544447,0.00966114521239857,FALSE
+"HCC44","Input","KEGG_CELL_CYCLE",-0.50846,-1.48,0.0424,12645,0.197,"TFDP2, STAG2, DBF4, ANAPC4, ORC5, TGFB3, SKP2, RBL2, CREBBP, PTTG2, CDK7, CDC14B, ANAPC1, ORC6, MAD2L2, RBL1, CDC26, ANAPC10, CHEK2, MCM4, BUB3, HDAC1, PCNA, YWHAQ, WEE1, ZBTB17, MCM2, CDK2, CDC20, CCND3, SMC1A, MCM6, CDC14A, CDK4, YWHAH, ANAPC5, ANAPC7, SKP1, MCM3, YWHAE, GSK3B, CDKN2C, PTTG1, MDM2, CDC45, ORC2, CCNB1, MCM5, YWHAZ, CDKN1B, ANAPC11, FZR1, SMC3, CDC23, ORC3, ORC4, E2F1, TTK, ORC1, CHEK1, E2F2, CDC27, CDC25B, PLK1, CCNA2, YWHAB, BUB1, CCNB2, MAD2L1, CDKN2D, TP53, CDK1, BUB1B, ESPL1, RBX1, CDC25C, RAD21, PKMYT1",1.37263414340727,0.705533773838407,TRUE
+"HCC44","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.19876,-0.584,0.975,11825,1,"ADCY5, VAV2, MAP2K1, PREX1, JAK3, PRKCD, AKT2, CXCR6, WASL, GRK7, GRK4, GNG2, GNG13, GNG5, CCL28, PIK3R3, PARD3, SHC3, CCL27, SOS2, RHOA, GNG7, GNB5, SHC2, CXCR4, AKT1, RASGRP2, CCL2, PRKACA, TIAM2, PIK3R1, RAP1A, PTK2, PLCB4, GNAI3, PRKCZ, ADCY6, CDC42, MAPK1, VAV3, CCR10, GRK5, CRKL, PIK3CA, ARRB1, GSK3B, ADCY9, STAT1, GRK2, PAK1, GRB2, KRAS, RELA, STAT2, IKBKB, GNB2, SOS1, GRK6, PRKX, ARRB2, HRAS, CSK, MAPK3, PIK3R2, PLCB3",0.0109953843014632,0,FALSE
+"HCC44","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.37997,-1.1,0.295,12387,0.617,"ARAF, PTPN11, PIK3R3, SHC3, SOS2, TGFB3, CBLC, SHC2, AKT1, CTBP2, PIK3R1, HDAC1, CBL, BCR, MAPK1, BCL2L1, CDK4, CRKL, PIK3CA, GAB2, MDM2, CDKN1B, GRB2, KRAS, RELA, E2F1, IKBKB, E2F2, SOS1, CTBP1, HRAS, TP53, MAPK3, PIK3R2, BAD",0.530177984021837,0.209714835966758,FALSE
+"HCC44","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.19943,-0.581,0.974,17357,1,"CRY2",0.0114410431213845,0,FALSE
+"HCC44","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.52036,-1.51,0.0391,14250,0.19,"DLAT, OGDH, OGDHL, SUCLA2, IDH2, SDHB, FH, SDHD, SDHC, PDHB, IDH1, IDH3A, MDH1, ACO2, PDHA1, SUCLG1",1.40782324260413,0.721246399047171,TRUE
+"HCC44","Input","KEGG_COLORECTAL_CANCER",-0.36807,-1.08,0.326,12342,0.647,"TCF7L2, ARAF, PIK3R3, CASP9, RAC3, MLH1, BCL2, TGFB3, RHOA, AXIN2, AKT1, MSH3, PIK3R1, APPL1, MAPK10, RALGDS, MSH6, MAPK1, LEF1, BAX, APC, MAPK9, PIK3CA, GSK3B, AXIN1, CASP3, TCF7L1, KRAS, BIRC5, TP53, MAPK3, PIK3R2, BAD",0.486782399932061,0.1890957193313,FALSE
+"HCC44","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.43012,1.62,0.04,1345,0.276,"THBD, CFB, PLAUR, C3, F3, SERPINE1, BDKRB1, TFPI, PLAU, C1S, CD55, C4A, BDKRB2",1.39794000867204,0.559090917934782,FALSE
+"HCC44","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.31599,-0.924,0.588,15274,0.974,"MTR, LDHA, SMS, ADI1, DNMT3B, DNMT3A, ENOPH1, MPST, GOT1, MAT2B",0.230622673923862,0.0114410431213845,FALSE
+"HCC44","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.42205,1.6,0.0408,1980,0.216,"OSM, TNFRSF9, TNFSF11, IL24, IL11, CSF3, CXCL5, TNFRSF18, TNFRSF6B, CXCL6, TNF, CXCL8, IL2, IFNE, CSF2, CXCL2, CCL20, VEGFC, CCL5, CXCL3, IL12B, IL6, TGFB2, BMP2, TNFRSF10D, IL1B, IL15RA, TNFRSF25, IL1A, IL13, TNFRSF10A, INHBE, IL6ST, TGFBR1, CSF1, IL20RB, CCL26, CLCF1, IL6R, IL7R, TNFSF14, CD70, OSMR, CXCR3, IFNA1, XCL1, TNFSF9, TGFB1, KITLG, TNFRSF4, CX3CL1, LTB, IFNGR1, TGFBR2, EGFR, PF4V1, IL2RG, VEGFA, RELT, IL22, TNFRSF12A, MET, IL1RAP, CXCL1, CD40, IL7, IL23A",1.38933983691012,0.665546248849069,TRUE
+"HCC44","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.22063,0.802,0.66,1635,0.895,"CCL5, IL6, IL1B, RIPK1, AIM2, IFNA1, NFKB1, NFKBIA, IKBKG",0.180456064458131,0.048176964684088,FALSE
+"HCC44","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.16076,-0.466,0.997,9251,1,"MYL2, LAMA2, SGCG, CACNA2D3, ADCY4, ITGA11, IGF1, SGCB, TPM1, SGCD, SGCA, CACNG7, ITGA10, CACNA1C, ADRB1, CACNB2, ITGA9, CACNA2D2, ITGA6, ADCY5, RYR2, DAG1, CACNG6, TNNT2, CACNA1D, TGFB3, TNNC1, CACNB4, CACNG8, ITGA4, ITGB6, PRKACA, ITGA2B, SLC8A1, LMNA, TNNI3, CACNG4, ADCY6, ITGA7, CACNA2D1, DMD, ITGB8, EMD, ADCY9, TPM3, PRKX, CACNB3",0.00130484168834428,0,FALSE
+"HCC44","Input","KEGG_DNA_REPLICATION",-0.58861,-1.74,0.00529,13452,0.103,"POLD1, POLA1, POLE, MCM4, RPA3, PCNA, MCM2, RFC4, MCM6, RFC2, POLE4, RPA2, MCM3, FEN1, RNASEH2A, POLD3, MCM5, RPA1, RFC5, POLD4, PRIM2, LIG1, DNA2, RNASEH2C, POLA2",2.27654432796481,0.987162775294828,TRUE
+"HCC44","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.36954,-1.08,0.344,11539,0.647,"NOTCH4, MAP2K1, SPIRE2, NOTCH3, SOS2, FMN2, CPEB1, MAPK1, GRB2, KRAS, SOS1, MAPK3",0.46344155742847,0.1890957193313,FALSE
+"HCC44","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.19587,-0.574,0.985,5790,1,"UGT2B11, GSTA3, CYP2A7, UGT2B4, CYP2A13, FMO2, ADH1B, ADH7, ADH4, UGT2B17, CYP1A2, FMO1, ADH1A, CYP3A43, UGT2A3, GSTM5, CYP2C19, UGT2B15, CYP2A6, GSTA2, FMO3, CYP2B6, ADH1C, CYP2C9, GSTK1, CYP2C18, CYP2C8, GSTA1, GSTM4, ADH6, MGST2, MAOA, CYP3A5, CYP3A7, CYP3A4, MAOB, UGT2B7, ALDH3B2, CYP2E1, CYP2D6, GSTM1, GSTM2, GSTT2, FMO5, GSTO1, GSTP1, FMO4, GSTA4, ADH5, MGST3",0.00656376950238827,0,FALSE
+"HCC44","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.20452,-0.602,0.972,18592,1,"UCK1, TK1",0.0123337350737254,0,FALSE
+"HCC44","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.26823,1.03,0.339,1952,0.675,"COL4A6, ITGA2, AGRN, TNXB, LAMC2, LAMB3, ITGA1, ITGA5, HSPG2, COL4A2, COL4A1, COL5A1, LAMB1, COL6A2, LAMA5, SDC4, LAMA3, COL6A1, THBS1, RELN, ITGAV, ITGB1, CD44, ITGA3",0.469800301796918,0.170696227168975,FALSE
+"HCC44","Input","KEGG_ENDOCYTOSIS",-0.43834,-1.28,0.124,13127,0.375,"ITCH, CBLC, SH3GL3, CLTB, VPS37B, AP2M1, ACAP1, RAB5A, CXCR4, RAB11FIP5, RAB11FIP3, HSPA1L, CHMP2B, PIP5K1A, AP2A1, EPN3, CBL, RUFY1, PARD6G, CLTC, PDCD6IP, WWP1, DNM3, EEA1, PRKCZ, IQSEC1, RAB4A, MVB12A, CDC42, FGFR2, ERBB3, SH3GLB1, VPS4A, RAB5C, VPS37C, FGFR4, SH3GL1, GRK5, RBSN, PIP4K2B, USP8, PSD, PARD6B, EPN1, ARRB1, RAB11FIP4, CHMP4B, CHMP2A, PARD6A, MDM2, RAB11B, AGAP1, GRK2, STAM2, SH3GLB2, VPS25, STAMBP, IQSEC2, MVB12B, VPS37A, VPS37D, CLTA, PIKFYVE, RNF41, ASAP3, TSG101, SRC, GIT2, SMAP1, CHMP3, GRK6, DNM1L, GIT1, SNF8, CHMP5, ARRB2, HRAS, EPS15, ARFGAP2, PLD2, ARAP1, VPS28, RAB5B, RAB11A",0.906578314837765,0.425968732272281,FALSE
+"HCC44","Input","KEGG_ENDOMETRIAL_CANCER",-0.44413,-1.27,0.134,11157,0.38,"NRAS, APC2, EGF, FOXO3, PIK3CB, MAP2K1, AKT2, TCF7L2, ARAF, PIK3R3, CASP9, MLH1, SOS2, AXIN2, AKT1, PIK3R1, MAPK1, PDPK1, LEF1, APC, PIK3CA, ELK1, GSK3B, AXIN1, TCF7L1, GRB2, KRAS, ERBB2, SOS1, ILK, HRAS, TP53, MAPK3, PIK3R2, BAD",0.872895201635192,0.42021640338319,FALSE
+"HCC44","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.43152,-1.26,0.141,14005,0.387,"JAM3, MAPK14, ATP6V0D1, MAPK10, ATP6V0B, ATP6V1G1, ATP6V0A1, ATP6V1G2, CDC42, ATP6V1B1, ATP6V0E2, PLCG2, MAPK9, ADAM10, ATP6V1A, ATP6V1H, ATP6V0C, CASP3, ATP6V1B2, PAK1, RELA, ATP6V1E1, IKBKB, ATP6V0E1, ATP6V1E2, MAPK11, SRC, PLCG1, ATP6V1C1, GIT1, CSK, ATP6V1F",0.85078088734462,0.412289034981089,FALSE
+"HCC44","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.39089,-1.14,0.238,12707,0.539,"PRKCG, PIK3R3, CAMK2B, SHC3, SOS2, CBLC, SHC2, AKT1, MAP2K7, PIK3R1, PTK2, MAPK10, NRG2, CBL, NRG4, PAK4, MAPK1, ERBB3, PAK6, EIF4EBP1, PLCG2, CRKL, MAPK9, CAMK2D, PIK3CA, ELK1, GSK3B, RPS6KB1, GAB1, PAK1, CDKN1B, CAMK2G, GRB2, KRAS, ERBB2, SOS1, NCK2, SRC, PLCG1, RPS6KB2, HRAS, MAPK3, PIK3R2, BAD",0.623423042943488,0.268411234813261,FALSE
+"HCC44","Input","KEGG_ETHER_LIPID_METABOLISM",-0.40118,-1.18,0.211,17652,0.501,"PLA2G4B, PAFAH1B3, PLA2G6, PAFAH2, PLD2, PLA2G12A",0.675717544702307,0.300162274132754,FALSE
+"HCC44","Input","KEGG_FATTY_ACID_METABOLISM",-0.53442,-1.56,0.0337,14150,0.149,"ECI1, ACADM, ACAT2, CPT1C, ACAA1, ACSL3, HADHA, EHHADH, GCDH, ALDH9A1, ECHS1, ACADS, CPT1B, ACOX1, ACADSB, HADHB, ACSL1, HADH, ADH5, ACAT1",1.47237009912866,0.826813731587726,TRUE
+"HCC44","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.29177,-0.852,0.735,13644,1,"AKT1, SYK, MAP2K7, PIK3R1, MAPK14, MAPK10, MAPK1, VAV3, PDPK1, PLCG2, MAPK9, PIK3CA, GAB2, MAP2K6, GRB2, KRAS, PLA2G4B, SOS1, PLA2G6, MAPK11, PLCG1, HRAS, MAPK3, PIK3R2, PLA2G12A",0.133712660915805,0,FALSE
+"HCC44","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.37069,-1.07,0.328,11163,0.66,"ARPC1A, PLA2G4F, FCGR2A, PIK3CB, WAS, DNM2, VAV2, MAP2K1, PRKCD, AKT2, WASL, SCIN, INPP5D, PRKCG, PIK3R3, MARCKSL1, MARCKS, PLPP1, AKT1, SYK, PIP5K1A, PIK3R1, VASP, ARPC4, DNM3, CDC42, MAPK1, VAV3, PLCG2, CRKL, PIP4K2B, PIK3CA, WASF2, GAB2, RPS6KB1, WASF3, PAK1, ARPC5, LIMK2, ARPC2, PIKFYVE, ASAP3, PLA2G4B, PLA2G6, PLCG1, GSN, RPS6KB2, DNM1L, SPHK2, CFL1, MAPK3, PIK3R2, PLD2, ARPC3",0.484126156288321,0.180456064458131,FALSE
+"HCC44","Input","KEGG_FOCAL_ADHESION",-0.20819,-0.607,0.966,10402,1,"COL6A3, PAK3, VEGFD, XIAP, RASGRF1, CAV1, MYLK3, MAPK8, ROCK1, ITGA10, LAMC3, PTEN, ARHGAP35, COL11A1, COL5A3, PXN, MYL9, MYLK2, ITGA9, ACTN2, EGF, PIK3CB, FLT4, COL1A1, ITGA6, VAV2, MAP2K1, AKT2, THBS2, COL3A1, CCND2, LAMA1, PRKCG, PIK3R3, RAC3, SHC3, SOS2, BCL2, COL11A2, PDGFRB, RHOA, COL1A2, MYLPF, PGF, PDGFC, SHC2, AKT1, TLN1, ITGA4, SPP1, ITGB6, THBS4, ITGA2B, CHAD, PIK3R1, RAP1A, MYL5, VASP, PTK2, MAPK10, PDGFD, PPP1CC, PAK4, CDC42, PDGFB, LAMA4, MAPK1, VAV3, PDPK1, CCND3, COL5A2, PAK6, ITGA7, FN1, CRKL, MAPK9, ITGB8, THBS3, PIK3CA, ELK1, GSK3B, RAPGEF1, PAK1, GRB2, ERBB2, SOS1, ILK, SRC, TLN2, PPP1CB, HRAS, MAPK3, PIK3R2, VEGFB, PPP1CA, BAD",0.0150228735845067,0,FALSE
+"HCC44","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.47339,-1.37,0.0705,14562,0.291,"GGH, QDPR, FPGS, SPR, DHFR",1.1518108830086,0.536107011014093,FALSE
+"HCC44","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.48366,-1.42,0.0389,15857,0.243,"PHPT1, GMPPB, MTMR6, TPI1, PFKL, ALDOA, PMM1, KHK, GMPPA, MPI, FPGT",1.41005039867429,0.614393726401688,TRUE
+"HCC44","Input","KEGG_GALACTOSE_METABOLISM",-0.44266,-1.3,0.106,11743,0.358,"GCK, PGM1, PGM2, HK1, GALE, PFKM, GALK1, B4GALT2, GAA, GLA, GALK2, PFKL, UGP2, GALT, GANC",0.97469413473523,0.446116973356126,FALSE
+"HCC44","Input","KEGG_GAP_JUNCTION",-0.34838,-1.03,0.406,10956,0.753,"DRD2, ADRB1, NRAS, EGF, TUBB8, GNAI2, GUCY1A2, ADCY5, TUBB2A, MAP2K1, PRKG1, PRKCG, GUCY1A1, SOS2, PDGFRB, PDGFC, TUBB4A, TUBA1A, PRKACA, PDGFD, GUCY1B1, PLCB4, GNAI3, TUBB2B, GNA11, ADCY6, PDGFB, MAPK1, MAP3K2, TUBB4B, TUBB, MAPK7, TUBA1B, ADCY9, GRB2, KRAS, SOS1, SRC, MAP2K5, GNAQ, PRKX, HRAS, CDK1, MAPK3, PLCB3",0.391473966422806,0.123205023799299,FALSE
+"HCC44","Input","KEGG_GLIOMA",-0.39728,-1.17,0.221,11127,0.494,"RB1, NRAS, EGF, PIK3CB, MAP2K1, MTOR, AKT2, ARAF, PRKCG, PIK3R3, CAMK2B, SHC3, SOS2, PDGFRB, SHC2, CALML6, AKT1, PIK3R1, CALM1, PDGFB, MAPK1, CDK4, PLCG2, CAMK2D, PIK3CA, MDM2, CAMK2G, GRB2, KRAS, E2F1, CALM2, E2F2, SOS1, PLCG1, HRAS, TP53, MAPK3, PIK3R2, CALM3",0.655607726314889,0.306273051076353,FALSE
+"HCC44","Input","KEGG_GLUTATHIONE_METABOLISM",-0.28621,-0.827,0.754,12431,1,"GPX7, GSTM2, GPX2, OPLAH, GPX4, GSTT2, GSTO1, RRM1, LAP3, IDH2, GSTP1, TXNDC12, SMS, RRM2, GSS, IDH1, RRM2B, GSTA4, MGST3",0.122628654130226,0,FALSE
+"HCC44","Input","KEGG_GLYCEROLIPID_METABOLISM",0.26218,0.96,0.48,1263,0.768,"GPAT2, AKR1B1, DGKH, GPAT3, PLPP3, DGKG, DGKE, DGAT2, DGKD, GK, DGKI",0.318758762624413,0.114638779968488,FALSE
+"HCC44","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.28063,-0.821,0.768,11448,1,"GPD1, PHOSPHO1, AGPAT3, CHKA, PLA2G10, PCYT1A, PCYT1B, LPCAT3, CDS1, PGS1, LCLAT1, PLPP1, LPCAT4, GPD2, PLA2G15, AGPAT2, ACHE, MBOAT1, ETNK1, LYPLA1, PTDSS2, DGKZ, GNPAT, LPGAT1, DGKQ, ETNK2, DGKA, CHKB, PLA2G4B, PLA2G6, PCYT2, CDS2, LYPLA2, PLD2, PLA2G12A, CDIPT",0.114638779968488,0,FALSE
+"HCC44","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.28303,-0.826,0.773,10800,1,"MAOA, MAOB, SHMT2, GNMT, SARDH, DLD, PSPH, PIPOX, GCAT, GATM, GLYCTK, SRR, GLDC, AMT, PHGDH, ALAS1, SHMT1, GAMT",0.111820506081675,0,FALSE
+"HCC44","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.4332,-1.27,0.122,13390,0.38,"PGK1, ALDH7A1, PFKM, DLAT, BPGM, GALM, PGAM4, GPI, GAPDH, LDHA, AKR1A1, ENO3, TPI1, ALDH9A1, ACSS1, PKM, PDHB, PFKL, ALDOA, ACSS2, PGAM1, PDHA1, ADH5",0.913640169325252,0.42021640338319,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.33629,1.3,0.0377,750,0.414,"CSGALNACT1, CHSY1, B3GALT6, CHST11, CHPF2, DSE",1.42365864979421,0.382999658879101,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.25001,-0.729,0.883,11027,1,"NDST3, B3GAT1, GLCE, EXT2, HS3ST3A1, NDST1, XYLT1, HS3ST3B1, EXTL3, B4GALT7, HS6ST1, XYLT2, NDST2, B3GAT3",0.0540392964224314,0,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.29609,-0.866,0.698,13130,1,"B3GNT7, CHST6, B4GALT2, B4GALT3, B4GAT1, B4GALT4",0.156144577376839,0,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.34584,-1.01,0.438,11770,0.806,"IDUA, HYAL1, HS3ST3A1, HYAL2, HS3ST3B1, HEXB, GALNS, HYAL3",0.3585258894959,0.0936649581949093,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.26843,1.04,0.441,13985,0.73,"ST3GAL1, SLC33A1, ST3GAL2, GLB1, ST6GALNAC4, ST3GAL5, HEXA, ST8SIA5, ST6GALNAC6, B4GALNT1, ST6GALNAC5, ST6GALNAC3, ST8SIA1, B3GALT4, HEXB",0.355561410532161,0.136677139879544,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.27799,-0.813,0.808,10376,1,"FUT9, FUT2, FUT1, GBGT1, ST8SIA1, HEXB, GLA, NAGA",0.0925886392254138,0,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.21628,-0.637,0.97,9786,1,"B3GNT2, B3GALT2, FUT9, ST3GAL6, FUT2, FUT1, ABO, B3GALT1, FUT3, ST8SIA1, B4GALT2, B3GNT4, B4GALT3, B4GAT1, B4GALT4",0.0132282657337552,0,FALSE
+"HCC44","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.53049,-1.57,0.0149,12054,0.145,"PIGB, PIGP, PIGZ, PIGN, PIGT, PIGA, PIGG, PIGK, PIGO, GPLD1, DPM2, PGAP1, PIGM, PIGF, PIGQ, PIGC, PIGV, PIGU, GPAA1",1.82681373158773,0.838631997765025,TRUE
+"HCC44","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.4592,-1.36,0.0791,12685,0.293,"AFMID, ACO1, GLYCTK, CS, GRHPR, PGP, MDH1, ACO2",1.10182351650232,0.533132379645891,FALSE
+"HCC44","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.40387,-1.19,0.189,13640,0.51,"CALML6, ATF4, MAP2K7, PRKACA, MAPK14, MAPK10, CALM1, PLCB4, GNA11, MAP3K1, ADCY6, CDC42, MAPK1, MAP3K2, MAPK9, CAMK2D, MAP3K3, MAPK7, ELK1, ADCY9, GNRH1, MAP2K6, CAMK2G, GRB2, KRAS, CALM2, PLA2G4B, SOS1, PLA2G6, MAPK11, SRC, GNAQ, PRKX, HRAS, MAPK3, PLD2, CALM3, PLA2G12A, PLCB3",0.723538195826756,0.292429823902064,FALSE
+"HCC44","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.6556,2.61,0,565,0.0206,"TNF, IL2, IL6, IL1B, IL1A",Inf,1.68613277963085,TRUE
+"HCC44","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.2018,-0.595,0.979,12191,1,"HHIP, WNT4, PTCH1, CSNK1G2, WNT10A, CSNK1G3, GAS1, WNT10B, BMP7, GLI1, PRKACA, BMP4, FBXW11, CSNK1G1, GSK3B, STK36, SMO, PRKX, BTRC, SUFU",0.00921730819686218,0,FALSE
+"HCC44","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.41787,1.74,0.0182,1254,0.22,"IL11, CSF3, CD38, TNF, CSF2, ITGA2, IL6, IL1B, IL1A, ITGA1, CSF1, ITGA5, IL6R, IL7R, CD55, KITLG, TFRC",1.73992861201493,0.657577319177794,TRUE
+"HCC44","Input","KEGG_HISTIDINE_METABOLISM",-0.28659,-0.831,0.753,10163,1,"AMDHD1, AOC1, MAOA, MAOB, ALDH3B2, ACY3, FTCD, ALDH7A1, LCMT2, ALDH9A1, HEMK1, LCMT1",0.123205023799299,0,FALSE
+"HCC44","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.64738,-1.89,0.00107,15780,0.0903,"BRCA2, RAD52, RPA2, MRE11, POLD3, RPA1, POLD4, RAD51C, EME1, BLM, RAD54L, MUS81, RAD51, RAD54B, SEM1",2.97061622231479,1.04431224968649,TRUE
+"HCC44","Input","KEGG_HUNTINGTONS_DISEASE",-0.57084,-1.68,0.00536,16086,0.106,"NDUFA9, NDUFS4, COX7B, POLR2E, CREB1, NDUFV2, ATP5PF, VDAC2, NDUFS5, CASP3, SLC25A4, NDUFA3, ATP5PB, POLR2J, NDUFB9, SDHD, SOD1, SDHC, COX6B1, COX7A2L, POLR2F, UQCRQ, CLTA, UQCRFS1, CREB3L4, UQCRC2, CYC1, DCTN2, SLC25A6, NDUFB7, NDUFB1, UQCR11, POLR2K, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, GNAQ, COX5A, DNAL4, NDUFA4, NDUFA10, NDUFS8, CREB3, NDUFS2, COX7C, POLR2G, NDUFV1, NDUFB8, VDAC3, NDUFB4, TP53, NDUFC2, ATP5F1C, DCTN1, POLR2L, SP1, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, PLCB3, NDUFA2, NDUFS3, SIN3A, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, COX8A, NDUFB3",2.27083521030723,0.97469413473523,TRUE
+"HCC44","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.17222,0.68,0.931,1065,0.91,"CACNA2D4, TNF, ITGA2, IL6, TGFB2, ITGA1, ITGA5, TPM4, TGFB1",0.0310503190186574,0.0409586076789064,FALSE
+"HCC44","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.47716,-1.4,0.0771,14947,0.258,"PIP4K2C, INPP5K, ITPKA, PLCG2, INPP4B, PIP4K2B, PI4KB, ITPKB, IPMK, PIK3CA, PI4KA, INPP5E, TPI1, PIKFYVE, INPPL1, INPP4A, PIK3C2B, PLCD1, PLCG1, CDIPT, PLCB3, INPP5B",1.11294562194904,0.58838029403677,FALSE
+"HCC44","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.42708,-1.26,0.136,11029,0.387,"PDE3A, RPTOR, NRAS, PRKAB2, FBP2, PRKAB1, PIK3CB, PRKCI, SLC2A4, GCK, MAP2K1, MTOR, SH2B2, AKT2, PRKAR2A, ARAF, INPP5D, PIK3R3, PPP1R3D, HK1, SHC3, SOS2, PDE3B, CBLC, FLOT2, INSR, TRIP10, FASN, SHC2, CALML6, AKT1, ACACB, TSC1, PPARGC1A, PRKACA, PIK3R1, MAPK10, CALM1, SORBS1, CBL, PPP1CC, LIPE, PHKB, PRKCZ, MAPK1, PDPK1, PRKAR1A, INPP5K, EIF4EBP1, EIF4E, PHKG2, PRKAR2B, CRKL, TSC2, MAPK9, PIK3CA, ELK1, FLOT1, GSK3B, RPS6KB1, MKNK1, RAPGEF1, PHKA2, GRB2, GYS1, KRAS, CALM2, PTPN1, IKBKB, EXOC7, SOS1, RPS6KB2, PRKX, PPP1CB, HRAS, PRKAG1, MAPK3, PIK3R2, CALM3, EIF4E2, PPP1CA, BAD",0.866461091629782,0.412289034981089,FALSE
+"HCC44","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.26305,1.01,0.386,1065,0.69,"IL2, IL6, IL15RA, MAP3K14, TGFB1",0.413412695328245,0.161150909262745,FALSE
+"HCC44","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30773,1.17,0.213,1020,0.546,"OSM, IL24, IL11, CSF3, IL2, IFNE, CSF2, SPRY2, IL12B, IL6, MYC, IL15RA, IL13, IL6ST, SPRY4, IL20RB, SOCS4, CLCF1, SOCS3, IL6R, SPRED1, IL7R, OSMR, IFNA1",0.671620396561262,0.262807357295263,FALSE
+"HCC44","Input","KEGG_LEISHMANIA_INFECTION",0.39455,1.41,0.06,1864,0.331,"NCF2, ITGB2, PTGS2, TNF, C3, IL12B, TGFB2, IL1B, IL1A, FOS, TLR2, CYBA, TGFB1, NFKB1, IFNGR1, NFKBIA, JUN, ITGB1",1.22184874961636,0.480172006224281,FALSE
+"HCC44","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.18632,0.704,0.84,1058,0.998,"ITK, NCF2, ITGB2, ICAM1, ARHGAP5, MYL12A, CLDN1, RAC2, CYBA, VCL",0.0757207139381184,0.000869458712628891,FALSE
+"HCC44","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.59875,-1.76,0.00624,15905,0.1,"HADHA, EHHADH, ALDH9A1, ECHS1, NAA80",2.20481541031758,1,TRUE
+"HCC44","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.28516,-0.824,0.772,17652,1,"PLA2G4B, PLA2G6, PLA2G12A",0.112382699664264,0,FALSE
+"HCC44","Input","KEGG_LONG_TERM_DEPRESSION",-0.31732,-0.937,0.559,11495,0.965,"GNAI2, GUCY1A2, PLA2G10, MAP2K1, CACNA1A, ARAF, PRKG1, PRKCG, GUCY1A1, RYR1, GNAO1, GUCY1B1, PPP2CB, PLCB4, GNAI3, GNA11, MAPK1, PPP2R1B, GNAZ, PPP2CA, PPP2R1A, KRAS, PLA2G4B, PLA2G6, GNAQ, HRAS, MAPK3, PLA2G12A, PLCB3",0.252588192113577,0.0154726866562074,FALSE
+"HCC44","Input","KEGG_LONG_TERM_POTENTIATION",-0.40745,-1.19,0.181,13640,0.51,"CALML6, ATF4, RPS6KA6, PRKACA, RAP1A, CALM1, PLCB4, PPP1CC, RAPGEF3, CAMK4, MAPK1, PPP3CB, PPP3CC, CAMK2D, RPS6KA1, CAMK2G, KRAS, CALM2, CHP1, GNAQ, PRKX, PPP1CB, HRAS, MAPK3, CALM3, PPP1CA, PLCB3",0.742321425130815,0.292429823902064,FALSE
+"HCC44","Input","KEGG_LYSINE_DEGRADATION",-0.50729,-1.5,0.0337,11803,0.186,"KMT5B, NSD1, SUV39H2, SETDB1, PIPOX, PLOD1, ALDH7A1, SETDB2, OGDH, SETD1A, ACAT2, OGDHL, AASDHPPT, KMT5A, NSD2, HADHA, EHHADH, GCDH, EHMT1, SETD1B, AADAT, KMT5C, ALDH9A1, NSD3, AASDH, ECHS1, EHMT2, SUV39H1, HADH, ACAT1",1.47237009912866,0.730487055782084,TRUE
+"HCC44","Input","KEGG_LYSOSOME",-0.38981,-1.14,0.244,13233,0.539,"SLC11A1, CLTB, AP3B2, GNPTG, ENTPD4, ACP2, PLA2G15, MCOLN1, ABCA2, GGA3, HEXB, AP1M1, ATP6V0D1, ATP6V0B, AP1S1, CLN3, GNPTAB, AP4E1, ATP6V0A1, SORT1, CLTC, AP3S1, AP1S2, AP4B1, NPC2, AP3B1, CTSA, GM2A, SCARB2, GAA, CTSH, GGA2, ATP6V1H, ATP6V0C, GLA, GGA1, AP1M2, GALNS, ARSA, SMPD1, LAPTM4A, AP3M2, CLTA, GALC, AP1B1, ASAH1, SLC17A5, AP3M1, SLC11A2, AP4M1, CTSV, AP3S2, ABCB9, NAGA",0.612610173661271,0.268411234813261,FALSE
+"HCC44","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.2661,-0.784,0.82,12927,1,"RAC3, CACNA1D, SOS2, CACNA1H, TGFB3, MAPT, PDGFRB, RASGRF2, FGF1, MAP4K1, RRAS, AKT1, ATF4, CACNB4, CACNG8, DUSP9, RASGRP2, HSPA1L, RAPGEF2, MAP2K7, RPS6KA6, PRKACA, MAPK14, RAP1A, FGF13, MAPK10, FAS, RPS6KA4, FGF12, DDIT3, CACNG4, MAP3K13, MAP3K1, FGF11, LAMTOR3, DUSP3, CDC42, PDGFB, MAPK8IP1, MAPK1, MAP3K2, RASA1, FGFR2, MAP3K6, NFATC4, MAPK8IP2, CACNA2D1, PPP3CB, FGFR4, STMN1, PPP3CC, CRKL, HSPB1, DAXX, MAPK9, MAP3K3, RPS6KA1, DUSP14, MAPK7, MAX, ARRB1, ELK1, CASP3, MAP2K6, STK4, MKNK1, PAK1, GRB2, KRAS, RELA, IKBKB, TAOK2, PLA2G4B, CHP1, CDC25B, SOS1, PLA2G6, MAP3K12, MAPK11, MAP2K5, TAOK3, PRKX, MAP3K11, ATF2, STK3, ARRB2, HRAS, TP53, MAPK3, PLA2G12A, PPM1B, TAB1, CACNB3, MAP4K2",0.0861861476162833,0,FALSE
+"HCC44","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26932,0.919,0.507,11955,0.834,"BHLHA15, HHEX, PAX4, NEUROD1, NEUROG3, IAPP, PKLR, INS, FOXA3, HNF4G, SLC2A2, HNF4A, HNF1A, PDX1, ONECUT1, HES1, MAFA, MNX1, HNF1B, GCK, FOXA2, NR5A2",0.294992040666664,0.0788339493622613,FALSE
+"HCC44","Input","KEGG_MELANOGENESIS",-0.3308,-0.972,0.508,11495,0.897,"GNAI2, WNT7A, KIT, WNT6, ADCY5, MAP2K1, FZD8, WNT4, TCF7L2, FZD3, PRKCG, CAMK2B, WNT10A, FZD7, CREBBP, GNAO1, CALML6, WNT10B, PRKACA, CALM1, PLCB4, GNAI3, FZD4, ADCY6, MAPK1, LEF1, DVL3, FZD2, CAMK2D, CREB1, GSK3B, ADCY9, TCF7L1, CAMK2G, KRAS, DVL2, CALM2, CREB3L4, GNAQ, PRKX, CREB3, HRAS, MAPK3, CALM3, PLCB3",0.294136287716081,0.0472075569559079,FALSE
+"HCC44","Input","KEGG_MELANOMA",-0.27923,-0.829,0.757,13205,1,"PDGFRB, FGF1, PDGFC, AKT1, PIK3R1, FGF13, PDGFD, FGF12, FGF11, PDGFB, MAPK1, CDK4, PIK3CA, MDM2, KRAS, E2F1, E2F2, HRAS, TP53, MAPK3, PIK3R2, BAD",0.120904120499927,0,FALSE
+"HCC44","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.1842,-0.534,0.991,18060,1,"GSTA4, ADH5, MGST3",0.00392634551472468,0,FALSE
+"HCC44","Input","KEGG_MISMATCH_REPAIR",-0.59309,-1.72,0.00426,12953,0.0972,"MLH1, POLD1, MSH3, RPA3, PCNA, MSH6, EXO1, RFC4, RFC2, RPA2, POLD3, RPA1, RFC5, POLD4, PMS2, LIG1",2.37059040089728,1.01233373507373,TRUE
+"HCC44","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38148,-1.12,0.263,12016,0.577,"MTOR, AKT2, EIF4B, STK11, PIK3R3, PGF, AKT1, ULK3, TSC1, RPS6KA6, PIK3R1, MAPK1, PDPK1, EIF4EBP1, EIF4E, TSC2, RPS6KA1, PIK3CA, RPS6KB1, ULK1, RPS6KB2, STRADA, MLST8, MAPK3, PIK3R2, VEGFB, EIF4E2",0.580044251510242,0.238824186844269,FALSE
+"HCC44","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.21614,0.772,0.783,1373,0.92,"SH2D1B, ITGB2, KLRC2, TNF, CSF2, ICAM1, ICAM2, TNFRSF10D, TNFRSF10A, RAET1E, KLRC3, RAC2, IFNA1, ULBP2, ULBP3, IFNGR1, LAT",0.106238237942057,0.0362121726544447,FALSE
+"HCC44","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.17276,0.684,0.873,14215,0.96,"GLP2R, PTGER2, SSTR1, P2RY11, ADRA2B, P2RX5, CHRNA9, ADORA2B, GABRE, HTR7, HRH1, NR3C1, BDKRB1, CHRNA10, GHSR, S1PR3, LHB, F2RL1, BDKRB2, PRSS3, HTR2C, TRPV1, PTGER4, GCGR, GLRB, LHCGR, P2RY13, MC1R, GALR2, PLG, LTB4R, ADRB2, CALCR, GIPR, LEPR, P2RY6, AVPR2, GRIN2D, C3AR1, C5AR1, LTB4R2, LPAR2, PTGDR, P2RY14, GLRA1, GRIN1, P2RX1, TAAR2, CHRNA1, TAAR5, NPBWR2, GPR156, HTR1A, CHRNB3, HTR5A, TAAR6, LPAR1, P2RY1, TAAR8, CSH1, SSTR4, GALR1, CHRM2, HTR1D, SSTR3, FSHB, AGTR2, PRLHR, GABRA6, TAAR9, CHRNA2, MAS1, BRS3, HTR4, ADRB3, GH2, ADORA2A, RXFP2, TACR1, THRB, NTSR2, CNR2, GLRA2, F2RL3, OPRM1, GLRA3, DRD3, CHRNA3, GRM1, LEP, ADRA1A, GZMA, GRIK1, MTNR1B, HTR2B, CCKAR, NPY2R, GABRG1, TAAR1, P2RX3, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CHRND, GABRA1, PRL, FPR1, P2RY10, P2RX2, GH1, NPY4R, HCRTR1, APLNR, TSHB, HCRTR2, GABRA4, GLP1R, GPR50, GABRB2, FPR3, OPRK1, CHRM5, F2, DRD5, RXFP1, MC3R, CCKBR, FPR2, HTR1F, AVPR1A, CRHR2, S1PR4, GRM7, AVPR1B, TACR3, HRH3, ADCYAP1R1, HTR2A, GABRR2, NPY5R, GRM5, NMUR2, ADRA1D, CGA, CHRNB4, CHRNG, CYSLTR1, VIPR2, GRIA1, HTR6, UTS2R, NPFFR1, GABRA5, GRM3, GRIK3, KISS1R, P2RY8, CRHR1, NMUR1, HTR1B, CHRNA4, GRM2, PTGER3, GHRHR, CHRNA6, GABRR1, PRSS1, CHRNB2, MC5R, P2RY4, F2RL2, NPBWR1, ADORA3, MC4R, MCHR2, AGTR1, MCHR1, PRSS2, GABRB1, OXTR, GABRG3, GRIA2, TRHR, SCTR, GRIK5, P2RY2, EDNRA, EDNRB, TSHR, CHRM1, GRID2, DRD1, CTSG, PTGER1, CNR1, GRM4, GRIN3A, GRIA4, OPRD1, GRIA3, GRM8, TSPO, NTSR1, GRPR, GABRA2, GABRP, PTGIR, LPAR4, GRIN2A, GRIN2B, PTH2R, NPFFR2, HRH2, MLNR, MTNR1A, SSTR2, GPR83, SSTR5, ADRA2A, GABRG2, GNRHR, TACR2, PRLR, NPY1R, GRIK4, DRD2, ADRB1, GABRD, P2RX7, GALR3, NMBR, PTGFR, CHRM4, GABBR2, CALCRL, GRIN2C, GRID1, GRIN3B, GABRQ, PTH1R, PTAFR, GABRB3, GHR, F2R, GRIK2, P2RX6, CHRNE, GPR35, PARD3, HRH4, S1PR1, CHRNA5, TBXA2R, ADRA1B, LPAR3, DRD4, CHRM3, VIPR1, GABRA3, ADRA2C, LPAR6, OPRL1",0.0589857562944303,0.0177287669604316,FALSE
+"HCC44","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.44127,-1.29,0.113,12681,0.362,"RIPK2, PIK3R3, CAMK2B, SHC3, SOS2, BCL2, RHOA, NGFR, SHC2, CALML6, AKT1, ATF4, MAP2K7, RPS6KA6, MAGED1, PIK3R1, MAPK14, RAP1A, MAPK10, KIDINS220, CALM1, RPS6KA4, YWHAQ, SORT1, MAP3K1, CAMK4, CDC42, ARHGDIB, MAPK1, PDPK1, TP73, NFKBIE, BAX, YWHAH, PLCG2, CRKL, MAPK9, CAMK2D, MAP3K3, RPS6KA1, MAPK7, PIK3CA, SH2B1, YWHAE, GSK3B, PRDM4, GAB1, IRAK4, RAPGEF1, YWHAZ, ARHGDIA, CAMK2G, GRB2, KRAS, RELA, CALM2, IKBKB, SOS1, MAPK11, PLCG1, MAP2K5, YWHAB, HRAS, TP53, CSK, MAPK3, PIK3R2, CALM3, BAD",0.94692155651658,0.441291429466834,FALSE
+"HCC44","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.42565,1.52,0.146,1602,0.252,"CD38, NAMPT, PNP, NT5E, NADK, NNMT, BST1, AOX1",0.835647144215563,0.598599459218456,FALSE
+"HCC44","Input","KEGG_NITROGEN_METABOLISM",-0.21551,-0.634,0.952,9246,1,"CA14, CA7, CA3, CA9, GLUD1, GLUD2, GLS2, CA13, AMT, CPS1, GLUL, CA5B",0.0213630516155257,0,FALSE
+"HCC44","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.22184,0.81,0.817,1146,0.913,"TNF, CXCL8, CXCL2, CCL5, IL6, IL1B, TNFAIP3, BIRC3, NFKB1",0.0877779434675845,0.039529222465701,FALSE
+"HCC44","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.67389,-1.98,0.00105,14399,0.0613,"RAD50, DCLRE1C, MRE11, FEN1, XRCC6, XRCC4, XRCC5, POLL, NHEJ1",2.97881070093006,1.21253952548158,TRUE
+"HCC44","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.39943,-1.17,0.208,11127,0.494,"RB1, NRAS, EGF, FOXO3, PIK3CB, MAP2K1, AKT2, ARAF, PRKCG, PIK3R3, CASP9, SOS2, RARB, AKT1, RXRA, PIK3R1, MAPK1, PDPK1, CDK4, PLCG2, PIK3CA, STK4, GRB2, RXRB, KRAS, E2F1, E2F2, ERBB2, SOS1, PLCG1, HRAS, TP53, MAPK3, PIK3R2, BAD",0.681936665037238,0.306273051076353,FALSE
+"HCC44","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.37977,-1.12,0.282,12365,0.577,"DTX4, DLL3, ADAM17, NOTCH3, DTX1, CREBBP, DLL1, CTBP2, HDAC1, PSENEN, RBPJ, DTX2, MAML2, DVL3, KAT2B, PSEN2, DVL2, APH1A, RFNG, CTBP1, CIR1",0.549750891680639,0.238824186844269,FALSE
+"HCC44","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.56433,-1.65,0.0127,13330,0.109,"CDK7, ERCC1, POLD1, ERCC4, POLE, RAD23B, RPA3, PCNA, CETN2, RFC4, RFC2, POLE4, ERCC5, RPA2, CUL4B, XPA, POLD3, RPA1, ERCC6, RFC5, POLD4, GTF2H5, LIG1, XPC, ERCC3, DDB1, RBX1, DDB2",1.89619627904404,0.962573502059376,TRUE
+"HCC44","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.29312,-0.858,0.724,11502,1,"TUSC3, MGAT5, ALG6, MGAT5B, MGAT1, MAN1C1, ALG8, ALG1, MGAT3, DPAGT1, B4GALT2, DPM2, B4GALT3, ALG12, MAN1B1, ALG10B, RPN2, MGAT4A, ALG14, ALG10, DPM1, DPM3",0.140261433802853,0,FALSE
+"HCC44","Input","KEGG_OLFACTORY_TRANSDUCTION",0.22342,0.847,0.571,9653,0.862,"OR4F16, OR2K2, OR5B21, OR4F3, OR2B6, OR2A7, OR13H1, OR2A42, OR13A1, CNGA3, OR4F17, OR1N1, OR2A12, CNGB1, OR2A1, OR51M1, OR51I2, OR6C6, OR52J3, OR4C16, OR10AD1, OR51I1, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR51E2, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR51B4, OR2AE1, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, CALML5, OR2V2, OR56A3, OR10H2, OR52B2, OR1B1, OR2L3, OR8D1, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5M11, OR13G1, PRKACB, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR5P3, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, OR10H1, OR8D2, OR2T33, OR1J2, OR2S2, OR2A5, OR52H1, CALML3, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, ADCY3, OR4D1, OR2C1, OR8G1, OR4F15, OR52B6, OR2A25, OR2D3, OR1Q1, OR8A1, OR2B2, OR1K1, OR2J3, CLCA2, OR10A6, OR2A2, OR8G5, OR11H4, OR10A4, GUCY2D, OR2L2, OR6B2, OR2D2, PRKG2, OR2AG1, OR10A3, OR10A2, OR7D2, OR2A14, OR13J1",0.243363891754152,0.0644927341752872,FALSE
+"HCC44","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53347,-1.58,0.0244,15010,0.149,"AMT, MTR, MTHFS, SHMT1, MTHFR, MTFMT, DHFR",1.61261017366127,0.826813731587726,TRUE
+"HCC44","Input","KEGG_OOCYTE_MEIOSIS",-0.53935,-1.57,0.0158,13899,0.145,"MAD2L2, CDC26, ANAPC10, RPS6KA6, PRKACA, CPEB1, PPP2CB, CALM1, YWHAQ, FBXW11, PPP1CC, ADCY6, MAPK1, CDK2, CDC20, PPP2R1B, SMC1A, PPP3CB, YWHAH, PPP3CC, ANAPC5, ANAPC7, CAMK2D, SKP1, RPS6KA1, STAG3, PPP2R5A, YWHAE, ADCY9, PTTG1, FBXO43, PPP2CA, CCNB1, PPP2R1A, YWHAZ, CAMK2G, ANAPC11, SMC3, CDC23, CALM2, SGO1, CDC27, CHP1, PLK1, PRKX, YWHAB, BUB1, CCNB2, MAD2L1, BTRC, PPP1CB, CDK1, PPP2R5B, MAPK3, ESPL1, RBX1, CALM3, PPP1CA, CDC25C, PKMYT1, PPP2R5D",1.80134291304558,0.838631997765025,TRUE
+"HCC44","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.26845,1.03,0.323,13985,0.675,"FUCA2, FUCA1, MANBA, GLB1, MAN2B1, NEU1, MAN2B2, NEU4, NEU2, HEXA, AGA, GBA, MAN2C1, NEU3, ENGASE, HEXB",0.490797477668897,0.170696227168975,FALSE
+"HCC44","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.63494,-1.85,0.00317,16086,0.0636,"NDUFA9, NDUFS4, COX7B, ATP6V1A, NDUFV2, ATP5PF, ATP6V1H, ATP6V0C, NDUFS5, NDUFA3, ATP6V1B2, ATP5PB, NDUFB9, SDHD, SDHC, COX6B1, COX7A2L, UQCRQ, UQCRFS1, ATP6V1E1, UQCRC2, ATP6V0E1, CYC1, ATP6V1E2, NDUFB7, NDUFB1, UQCR11, ATP5PD, UQCRHL, ATP5F1E, ATP6V1C1, NDUFA8, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, NDUFV1, ATP5MG, NDUFB8, NDUFB4, NDUFC2, ATP5F1C, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, ATP5ME, COX6A1, NDUFA2, ATP6V1F, NDUFS3, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, COX15, UQCRB, COX8A, NDUFB3",2.49894073778225,1.19654288435159,TRUE
+"HCC44","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.2893,1.04,0.347,1723,0.73,"GALNT14, GALNT18, GALNT5, GALNT3, GCNT4, ST3GAL1, ST3GAL2, GALNT6",0.459670525209126,0.136677139879544,FALSE
+"HCC44","Input","KEGG_P53_SIGNALING_PATHWAY",-0.45955,-1.34,0.0875,13819,0.32,"PPM1D, CHEK2, SHISA5, FAS, BBC3, CDK2, EI24, CCND3, TP73, CDK4, BAX, TSC2, SESN3, SESN1, MDM2, RRM2, CASP3, CCNB1, RCHY1, GTSE1, PIDD1, CHEK1, TP53I3, COP1, RRM2B, CCNB2, CCNG2, TP53, CDK1, DDB2, APAF1",1.05799194697769,0.494850021680094,FALSE
+"HCC44","Input","KEGG_PANCREATIC_CANCER",-0.35801,-1.06,0.351,14157,0.672,"PIK3R1, MAPK10, RALGDS, CDC42, MAPK1, BCL2L1, CDK4, MAPK9, BRCA2, PIK3CA, RALBP1, STAT1, KRAS, RELA, E2F1, IKBKB, E2F2, ERBB2, RALB, TP53, MAPK3, PIK3R2, VEGFB, RAD51, BAD",0.454692883534176,0.172630726946175,FALSE
+"HCC44","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.26331,-0.767,0.851,15876,1,"PPCS, COASY, PPCDC",0.0700704399154121,0,FALSE
+"HCC44","Input","KEGG_PARKINSONS_DISEASE",-0.62627,-1.82,0.0042,16086,0.0705,"NDUFA9, NDUFS4, COX7B, NDUFV2, ATP5PF, VDAC2, NDUFS5, CASP3, SLC25A4, NDUFA3, ATP5PB, NDUFB9, SDHD, SDHC, COX6B1, COX7A2L, UQCRQ, UQCRFS1, UQCRC2, CYC1, SLC25A6, HTRA2, NDUFB7, NDUFB1, UQCR11, UBE2L3, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, UBA1, NDUFV1, NDUFB8, VDAC3, NDUFB4, NDUFC2, ATP5F1C, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, NDUFA2, NDUFS3, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, COX8A, NDUFB3",2.3767507096021,1.1518108830086,TRUE
+"HCC44","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.32696,-0.958,0.535,13176,0.932,"TLR5, RHOA, TLR4, TUBB4A, CTTN, TUBA1A, YWHAQ, ARPC4, TUBB2B, CDC42, TUBB4B, TUBB, TUBA1B, YWHAZ, ARPC5, ARPC2, NCK2, ARPC3",0.271646217978772,0.0305840876460186,FALSE
+"HCC44","Input","KEGG_PATHWAYS_IN_CANCER",-0.24669,-0.725,0.899,12842,1,"WNT10A, TFG, CASP9, RAC3, MLH1, FZD7, SOS2, BCL2, TGFB3, SKP2, CBLC, PDGFRB, CREBBP, RHOA, FGF1, PGF, RARB, CSF2RA, AXIN2, AKT1, CKS1B, WNT10B, DAPK2, RXRA, CCDC6, GLI1, CTBP2, MSH3, ITGA2B, PIK3R1, APPL1, HDAC1, PTK2, FGF13, MAPK10, BMP4, FAS, RALGDS, CBL, FGF12, MSH6, TRAF5, FGF11, FZD4, BCR, CDC42, PDGFB, LAMA4, MAPK1, BCL2L1, CDK2, FGFR2, LEF1, CDK4, BAX, DVL3, APC, FN1, DAPK1, PLCG2, CRKL, FZD2, MAPK9, GSTP1, BRCA2, NCOA4, FH, MAX, PIK3CA, RALBP1, GSK3B, AXIN1, MDM2, CASP3, STAT1, STK36, TPM3, TCF7L1, STK4, PIAS3, CDKN1B, ELOC, FADD, GRB2, RXRB, KRAS, BIRC5, DVL2, RELA, E2F1, SMO, IKBKB, PIAS1, E2F2, PML, ERBB2, SOS1, EGLN2, PLCG1, RALB, ARNT, CTBP1, SUFU, HRAS, TP53, MAPK3, PIK3R2, RBX1, VEGFB, ELOB, RAD51, BAD",0.0462403082667712,0,FALSE
+"HCC44","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.39454,-1.16,0.222,14856,0.504,"XYLB, RPEL1, RPE, UGP2, DCXR",0.653647025549361,0.297569463554475,FALSE
+"HCC44","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.33773,-0.98,0.481,14924,0.891,"GPI, DERA, RPEL1, PRPS2, PFKL, ALDOA, RPE",0.317854923626168,0.0501222959631252,FALSE
+"HCC44","Input","KEGG_PEROXISOME",-0.56653,-1.65,0.0187,14879,0.109,"FAR2, AGPS, ACAA1, IDH2, SLC25A17, ACSL3, GNPAT, PEX1, DECR2, EHHADH, PEX16, NUDT12, CAT, ABCD4, AMACR, PEX14, PAOX, SOD1, HMGCL, PEX6, CROT, FAR1, IDH1, PMVK, MPV17, PHYH, ACOX1, PEX26, ACSL1, PXMP4, PECR, PEX13, PEX19, ACOT8, PEX11A, PEX2, PEX11B, MVK, PRDX5",1.7281583934635,0.962573502059376,TRUE
+"HCC44","Input","KEGG_PHENYLALANINE_METABOLISM",-0.30137,-0.869,0.685,18020,1,"GOT1, NAA80",0.164309428507574,0,FALSE
+"HCC44","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.40758,-1.19,0.183,12578,0.51,"CDS1, INPP5D, PRKCG, PIK3R3, PLCD4, PIK3C2A, PIK3C3, IMPA2, CALML6, PIP5K1A, PIK3R1, CALM1, PLCB4, PIP4K2C, INPP5K, ITPKA, PLCG2, DGKZ, INPP4B, PIP4K2B, PI4KB, ITPKB, PIK3CA, PI4KA, INPP5E, DGKQ, CALM2, DGKA, PIKFYVE, INPPL1, INPP4A, PIK3C2B, PLCD1, PLCG1, CDS2, PIK3R2, CALM3, CDIPT, PLCB3, INPP5B",0.737548910269571,0.292429823902064,FALSE
+"HCC44","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.4969,-1.47,0.0305,13076,0.196,"BLVRB, UROS, HCCS, EARS2, BLVRA, CPOX, ALAS1, HMBS, HMOX2, MMAB, PPOX, ALAD, COX15",1.51570016065321,0.707743928643524,TRUE
+"HCC44","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.28413,-0.827,0.761,13748,1,"SCP2, RXRA, ACADM, SORBS1, NR1H3, CPT1C, PDPK1, ACAA1, ACSL3, EHHADH, UBC, SCD5, RXRB, SLC27A4, CPT1B, ILK, ACOX1, SLC27A1, ACSL1, DBI",0.118615343229427,0,FALSE
+"HCC44","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.30544,-0.904,0.642,11696,1,"CYP7B1, CYP46A1, CYP27A1, HSD17B4, SCP2, AMACR",0.192464971931147,0,FALSE
+"HCC44","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.20933,-0.61,0.977,8705,1,"CD79A, PTPRC, CD3D, LCK, ZAP70, BTK, IGLL1, CD19, CD8A, RFXAP, BLNK, JAK3, CD4, TNFRSF13C, RAG1, DCLRE1C, ADA, RFXANK, RFX5, UNG",0.0101054362812269,0,FALSE
+"HCC44","Input","KEGG_PRION_DISEASES",0.24129,0.911,0.517,1251,0.782,"CCL5, IL6, IL1B, IL1A, HSPA5, HSPA1A, EGR1",0.286509456906058,0.106793246940152,FALSE
+"HCC44","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.46708,-1.36,0.0792,13899,0.293,"MAD2L2, CDC26, ANAPC10, RPS6KA6, PRKACA, PIK3R1, MAPK14, CPEB1, MAPK10, GNAI3, ADCY6, MAPK1, CDK2, ANAPC5, ANAPC7, MAPK9, RPS6KA1, PIK3CA, ADCY9, CCNB1, KRAS, ANAPC11, FZR1, CDC23, CDC27, CDC25B, MAPK11, PLK1, CCNA2, PRKX, BUB1, CCNB2, MAD2L1, CDK1, MAPK3, PIK3R2, CDC25C, PKMYT1",1.10127481841051,0.533132379645891,FALSE
+"HCC44","Input","KEGG_PROPANOATE_METABOLISM",-0.56638,-1.65,0.0125,13553,0.109,"ALDH7A1, ACACB, ACADM, ACAT2, SUCLA2, LDHA, ABAT, HADHA, EHHADH, ALDH9A1, ACSS1, ECHS1, MCEE, ACSS2, SUCLG1, ACAT1, HIBCH",1.90308998699194,0.962573502059376,TRUE
+"HCC44","Input","KEGG_PROSTATE_CANCER",-0.3657,-1.09,0.32,12908,0.636,"CASP9, SOS2, BCL2, PDGFRB, CREBBP, PDGFC, AKT1, ATF4, PIK3R1, PDGFD, PDGFB, MAPK1, CDK2, FGFR2, PDPK1, LEF1, GSTP1, PIK3CA, CREB1, GSK3B, MDM2, TCF7L1, CDKN1B, GRB2, KRAS, RELA, E2F1, CREB3L4, IKBKB, E2F2, ERBB2, SOS1, CREB3, HRAS, TP53, MAPK3, PIK3R2, BAD",0.494850021680094,0.196542884351586,FALSE
+"HCC44","Input","KEGG_PROTEASOME",-0.4455,-1.31,0.112,11249,0.353,"PSMD7, PSMD2, PSMD3, PSMC5, PSMB7, PSMA5, PSMB1, PSMD6, PSMF1, PSMB10, PSMB2, PSMA1, PSMB5, PSMA2, PSMB4, PSMC2, PSMB3, PSMA4, PSMD1, PSMD4, PSMD13, PSMB6, PSMD14, PSMC3, SEM1",0.950781977329818,0.452225294612177,FALSE
+"HCC44","Input","KEGG_PROTEIN_EXPORT",-0.39777,-1.17,0.217,14823,0.494,"SPCS1, SRP68, SEC61A2, SEC11A, SPCS2, SRP9, IMMP1L, SRP14",0.66354026615147,0.306273051076353,FALSE
+"HCC44","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23545,-0.69,0.92,17617,1,"SLC25A10, MDH1",0.0362121726544447,0,FALSE
+"HCC44","Input","KEGG_PURINE_METABOLISM",-0.28405,-0.832,0.735,11825,1,"ADCY5, POLR2C, PDE6B, POLR1B, ITPA, NME1, POLR2A, ADCY10, PDE4C, NUDT5, ENTPD2, AK5, PDE1C, ENTPD8, NME5, PDE8B, POLR3B, GUCY1A1, PDE3B, POLR3GL, NT5C, ENTPD4, POLD1, PDE5A, POLA1, POLR2D, POLE, ENTPD6, PRUNE1, GUCY1B1, POLR2H, NT5M, ADCY6, DCK, RRM1, NPR2, POLE4, PRPS2, ADA, GMPR, POLR2I, PDE9A, POLR2E, POLR3K, ADCY9, RRM2, DGUOK, POLR2J, POLD3, AK1, NME6, PKM, GUK1, POLR2F, POLD4, RRM2B, PRIM2, POLR2K, NUDT2, NUDT9, POLR2G, POLR2L, POLA2, PAPSS1, PDE6D",0.133712660915805,0,FALSE
+"HCC44","Input","KEGG_PYRIMIDINE_METABOLISM",-0.36115,-1.06,0.354,13319,0.672,"POLR3GL, NT5C, ENTPD4, POLD1, POLA1, POLR2D, POLE, ENTPD6, POLR2H, NT5M, TXNRD2, DCK, RRM1, POLE4, POLR2I, POLR2E, POLR3K, RRM2, POLR2J, POLD3, NME6, POLR2F, POLD4, RRM2B, PRIM2, POLR2K, NUDT2, DUT, CTPS2, POLR2G, UPRT, UCK1, DTYMK, POLR2L, POLA2, TK1",0.450996737974212,0.172630726946175,FALSE
+"HCC44","Input","KEGG_PYRUVATE_METABOLISM",-0.45442,-1.33,0.101,13327,0.331,"HAGHL, ALDH7A1, ACACB, DLAT, ACAT2, LDHA, GLO1, GRHPR, ALDH9A1, ACYP2, ACSS1, PKM, PDHB, ACSS2, MDH1, HAGH, PDHA1, ACAT1",0.995678626217357,0.480172006224281,FALSE
+"HCC44","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.29494,-0.871,0.713,13205,1,"PDGFRB, RHOA, FGD3, FGF1, MYLPF, PDGFC, RRAS, IQGAP2, CHRM3, ITGA4, IQGAP1, PIP5K1A, ITGAE, ITGB6, ITGA2B, TIAM2, PIK3R1, MYL5, PTK2, FGF13, PDGFD, ARPC4, FGF12, PPP1CC, FGF11, PAK4, CDC42, PDGFB, MAPK1, PIP4K2C, MYH14, VAV3, FGFR2, PAK6, ITGA7, APC, FGFR4, FN1, CRKL, SSH2, PFN1, PIP4K2B, NCKAP1, ITGB8, PIK3CA, WASF2, IQGAP3, BRK1, SSH3, FGD1, PAK1, ARPC5, KRAS, CYFIP2, LIMK2, CYFIP1, ARPC2, PIKFYVE, SOS1, ABI2, GSN, CFL1, GIT1, PPP1CB, HRAS, CSK, MAPK3, PIK3R2, ARPC3, PPP1CA",0.146910470148134,0,FALSE
+"HCC44","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.3692,-1.07,0.326,11925,0.66,"ATG5, GABARAPL2, PIK3R4, PIK3C3, GABARAPL1, ATG12, ULK3, BECN1, ATG4C, ATG4D, ATG3, GABARAP, ULK1, ATG4B",0.486782399932061,0.180456064458131,FALSE
+"HCC44","Input","KEGG_RENAL_CELL_CARCINOMA",-0.40483,-1.17,0.217,11880,0.494,"MAP2K1, CUL2, AKT2, ARNT2, ARAF, PTPN11, PIK3R3, SOS2, TGFB3, CREBBP, PGF, AKT1, PIK3R1, RAP1A, FLCN, PAK4, CDC42, PDGFB, MAPK1, PAK6, CRKL, FH, PIK3CA, GAB1, RAPGEF1, PAK1, ELOC, GRB2, KRAS, SOS1, EGLN2, ARNT, HRAS, MAPK3, PIK3R2, RBX1, VEGFB, ELOB",0.66354026615147,0.306273051076353,FALSE
+"HCC44","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.24293,-0.711,0.902,7767,1,"CPA3, MME, AGTR1, CMA1, CTSG, ACE2, NLN, LNPEP, THOP1, CTSA",0.0447934624580583,0,FALSE
+"HCC44","Input","KEGG_RETINOL_METABOLISM",-0.21094,-0.621,0.965,17948,1,"RETSAT, ADH5, DGAT1",0.0154726866562074,0,FALSE
+"HCC44","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.26854,-0.787,0.817,8605,1,"ACP5, ENPP1, ENPP3, ACP4, MTMR2, ACP2, ACP1, PHPT1, MTMR6",0.0877779434675845,0,FALSE
+"HCC44","Input","KEGG_RIBOSOME",-0.26248,-0.764,0.851,15502,1,"RPL8, RPL37A, RPLP2, RPL41, RPL38, RPS2, RPL30, RPS27L, RPS4X, RPS26, MRPL13, RPLP1, FAU",0.0700704399154121,0,FALSE
+"HCC44","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.20584,-0.603,0.966,14164,1,"PIN1, MAPK14, MAPK10, MAP3K1, NLRX1, SIKE1, TBKBP1, MAPK9, TRADD, TANK, FADD, RELA, MAVS, IKBKB, MAPK11, OTUD5, TKFC",0.0150228735845067,0,FALSE
+"HCC44","Input","KEGG_RNA_DEGRADATION",-0.52036,-1.51,0.0319,15192,0.19,"PAPOLG, XRN1, LSM8, CNOT7, DCP2, MTREX, LSM6, CNOT9, ZCCHC7, ENO3, EDC3, C1D, EXOSC3, LSM1, CNOT6, DDX6, LSM2, WDR61, EXOSC4, LSM3, CNOT6L, LSM4, EXOSC1, PARN, CNOT8",1.49620931694282,0.721246399047171,TRUE
+"HCC44","Input","KEGG_RNA_POLYMERASE",-0.44571,-1.3,0.102,11507,0.358,"POLR3D, POLR2C, POLR1B, POLR2A, POLR3B, POLR3GL, POLR2D, POLR2H, POLR2I, POLR2E, POLR3K, POLR2J, POLR2F, POLR2K, POLR2G, POLR2L",0.991399828238082,0.446116973356126,FALSE
+"HCC44","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.37925,-1.11,0.27,17182,0.597,"HEMK1, SEPHS2, MAT2B, PAPSS1, LCMT1",0.568636235841013,0.224025668870631,FALSE
+"HCC44","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.22876,0.858,0.654,1952,0.87,"PTGS2, COL4A6, FHIT, TRAF1, ITGA2, LAMC2, MYC, CDKN2B, LAMB3, E2F3, TRAF3, COL4A2, COL4A1, BIRC3, NFKB1, LAMB1, LAMA5, NFKBIA, IKBKG, LAMA3, ITGAV, ITGB1, ITGA3",0.184422251675733,0.0604807473813815,FALSE
+"HCC44","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.40795,-1.2,0.167,13791,0.511,"VTI1B, VAMP2, STX12, STX3, STX2, VAMP4, BNIP1, STX18, STX17, STX6, STX5, SNAP47, STX4, STX10, TSNARE1, SNAP29, STX7, SNAP23",0.777283528852417,0.291579099865287,FALSE
+"HCC44","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.27985,-0.817,0.799,13121,1,"NEU3, CERK, PLPP1, SMPD3, ACER2, SGPL1, ACER3, GLA, ARSA, SMPD1, GALC, SMPD4, ASAH1, SPHK2",0.0974532206860086,0,FALSE
+"HCC44","Input","KEGG_SPLICEOSOME",-0.50857,-1.49,0.0392,13455,0.192,"HNRNPM, SF3A3, SNRNP40, LSM5, LSM7, MAGOH, HSPA1L, PRPF31, PRPF18, U2AF1, DDX23, PHF5A, SMNDC1, AQR, CRNKL1, DHX8, PRPF8, HNRNPK, SNRPB2, PRPF19, HNRNPU, PPIE, SF3B4, SNRPD2, SNRPF, LSM8, SF3B6, SNRNP200, PLRG1, SNRPE, SRSF3, LSM6, SF3A1, RBM17, PRPF38A, SNRPD1, SNRNP27, SF3B1, PRPF40A, WBP11, LSM2, CCDC12, SNRPC, USP39, PPIH, SNRPA, SYF2, SART1, SLU7, SNRPG, SF3B2, LSM3, CWC15, PRPF40B, SRSF9, LSM4, ZMAT2, XAB2, PUF60, PQBP1, PCBP1, CTNNBL1, THOC3, HNRNPA3, SNRPD3",1.40671393297954,0.71669877129645,TRUE
+"HCC44","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.21969,-0.644,0.956,8696,1,"PYGB, PYGM, ENPP1, AMY2B, ENPP3, AGL, MGAM, HK3, TREH, UGT2B7, GCK, PGM1, PGM2, HK1, PGM2L1, GPI, UXS1, GAA, GYS1, UGP2, GANC",0.0195421077238999,0,FALSE
+"HCC44","Input","KEGG_STEROID_BIOSYNTHESIS",-0.63231,-1.85,0.00419,15389,0.0636,"TM7SF2, EBP, NSDHL, SQLE, LSS, MSMO1, FDFT1, SC5D, HSD17B7",2.3777859770337,1.19654288435159,TRUE
+"HCC44","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.19263,0.682,0.901,1142,0.934,"SRD5A2, CYP1B1, HSD11B2, AKR1C3, AKR1C1",0.045275209020937,0.0296531237699066,FALSE
+"HCC44","Input","KEGG_SULFUR_METABOLISM",-0.67475,-1.98,0.00106,17252,0.0613,"CHST12, BPNT1, SULT1A3, SUOX, PAPSS1",2.97469413473523,1.21253952548158,TRUE
+"HCC44","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.17888,-0.529,0.995,16160,1,"SSB, TRIM21, SNRPD1, SNRPD3",0.00217691925427455,0,FALSE
+"HCC44","Input","KEGG_TASTE_TRANSDUCTION",0.33855,1.22,0.204,1532,0.479,"TAS2R46, TAS2R14, TAS2R43, TAS2R9, TAS1R3, TAS2R4, ITPR3, TAS2R13, TAS2R10, TAS2R5",0.690369832574101,0.319664486585437,FALSE
+"HCC44","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.35056,1.31,0.125,12415,0.44,"GGT1, GAD1, GAD2, BAAT, GGT5, GGT7, ADO, GGT6, CDO1, CSAD",0.903089986991944,0.356547323513813,FALSE
+"HCC44","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.63339,-1.87,0.00106,13801,0.0794,"HMGCR, GGPS1, ACAT2, PDSS2, MVD, HMGCS1, IDI1, PMVK, ACAT1, MVK",2.97469413473523,1.1001794975729,TRUE
+"HCC44","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.26954,-0.791,0.815,12104,1,"ACVR1C, DCN, ID1, THBS2, ZFYVE16, SMAD9, CHRD, TGFB3, RBL2, CREBBP, RHOA, ID4, ACVR2A, RBL1, BMP7, ID2, THBS4, BMPR1A, BMP4, PPP2CB, SMAD6, MAPK1, PPP2R1B, ACVR1, SKP1, ZFYVE9, THBS3, ACVR2B, PPP2CA, SMAD5, RPS6KB1, PPP2R1A, BMPR2, RPS6KB2, MAPK3, RBX1, SP1",0.0888423912600234,0,FALSE
+"HCC44","Input","KEGG_THYROID_CANCER",-0.42694,-1.25,0.144,13926,0.401,"RXRA, CCDC6, MAPK1, LEF1, NCOA4, TPM3, TCF7L1, RXRB, KRAS, HRAS, TP53, MAPK3",0.84163750790475,0.396855627379818,FALSE
+"HCC44","Input","KEGG_TIGHT_JUNCTION",-0.30876,-0.898,0.642,11065,1,"MYL9, NRAS, ACTN2, CLDN9, MAGI2, PRKCI, CRB3, PATJ, GNAI2, MAP3K20, IGSF5, JAM2, PRKCD, AKT2, CSNK2A1, PRKCG, PARD3, CLDN22, EPB41L3, RHOA, PPP2R2B, EPB41, MYLPF, TJP3, RRAS, PRKCQ, CTTN, AKT1, MYH11, CLDN3, JAM3, MYL5, PPP2CB, LLGL1, PARD6G, SPTAN1, GNAI3, PRKCZ, PPP2R2D, CDC42, MYH14, CASK, PPP2R1B, CDK4, MAGI3, LLGL2, TJAP1, PARD6B, PARD6A, PPP2CA, PPP2R2A, CGN, PPP2R1A, KRAS, MPDZ, EPB41L1, SRC, HRAS",0.192464971931147,0,FALSE
+"HCC44","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.18443,-0.548,0.99,13969,1,"SPP1, MAP2K7, PIK3R1, MAPK14, MAPK10, MAPK1, TICAM1, IRF5, MAPK9, IFNAR1, TLR3, PIK3CA, STAT1, MAP2K6, IRAK4, FADD, RELA, IKBKB, MAPK11, TOLLIP, MAPK3, PIK3R2, TAB1",0.00436480540245009,0,FALSE
+"HCC44","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.30515,-0.894,0.641,14333,1,"OGDH, ACAT2, OGDHL, HADHA, EHHADH, GCDH, CAT, AADAT, ALDH9A1, ECHS1, HADH, ACAT1",0.193141970481183,0,FALSE
+"HCC44","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.2847,-0.824,0.766,9549,1,"PIK3R5, PIK3CD, HK3, CACNA1B, PDX1, MAPK8, CACNA1C, MAFA, PIK3CB, CACNA1G, SLC2A4, GCK, MTOR, PRKCD, CACNA1A, PIK3R3, HK1, CACNA1D, INSR, KCNJ11, PIK3R1, MAPK10, PRKCZ, MAPK1, MAPK9, PIK3CA, PKM, IKBKB, MAPK3, PIK3R2",0.115771230367396,0,FALSE
+"HCC44","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.59358,2.09,0.0238,1735,0.0997,"TNF, IL2, IL12B, IL1B, IL1A, GAD1, CPE, ICA1",1.62342304294349,1.00130484168834,TRUE
+"HCC44","Input","KEGG_TYROSINE_METABOLISM",-0.32666,-0.948,0.548,17182,0.942,"HEMK1, GOT1, NAA80, ADH5, LCMT1",0.261219441515631,0.0259490972071227,FALSE
+"HCC44","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26296,-0.771,0.854,13042,1,"SOS2, CBLC, RHOA, PRKCQ, AKT1, NFATC3, MAP2K7, PIK3R1, MAPK14, CBL, PAK4, CDC42, MAPK1, VAV3, PDPK1, PAK6, NFATC4, CDK4, NFKBIE, PPP3CB, PPP3CC, MAPK9, PIK3CA, GSK3B, PAK1, GRB2, KRAS, RELA, IKBKB, CHP1, SOS1, NCK2, MAPK11, PLCG1, HRAS, MAPK3, PIK3R2",0.068542129310995,0,FALSE
+"HCC44","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.49681,-1.46,0.0451,13127,0.202,"ITCH, SKP2, CBLC, UBE2B, ANAPC1, UBE2D3, PRKN, FANCL, TRIP12, UBE2Q2, CDC26, ANAPC10, UBE2D2, UBE2N, UBE2Q1, KLHL9, CBL, FBXW11, PRPF19, WWP1, MAP3K1, UBE2Z, MID1, UBE2K, CDC20, SAE1, ANAPC5, UBE2G1, RNF7, ANAPC7, UBE2D1, SKP1, KLHL13, UBE2F, HUWE1, CUL4B, UBE2W, UBA6, HERC3, MDM2, FBXO4, UBR5, PIAS3, CDC34, UBE4B, ELOC, CUL3, ANAPC11, MGRN1, HERC2, FZR1, RCHY1, CDC23, RHOBTB2, UBA3, BRCA1, UBE3B, PIAS1, PPIL2, CDC27, PML, COP1, UBE2L3, STUB1, UBOX5, UBE2I, DDB1, UBE2R2, UBA1, BTRC, CUL7, UBE2C, HERC1, RBX1, ELOB, DDB2",1.34582345812204,0.694648630553376,TRUE
+"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.59423,-1.73,0.00642,17102,0.0998,"PDHB, IARS2, PDHA1",2.19246497193115,1.00086945871263,TRUE
+"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.5125,-1.5,0.0298,12913,0.186,"IVD, BCKDHB, ALDH7A1, DBT, ACADM, ACAT2, ACAA1, ABAT, HADHA, EHHADH, HMGCL, ALDH9A1, HMGCS1, AUH, ECHS1, ACADS, MCEE, ACADSB, HADHB, HSD17B10, HADH, ACAT1, HIBCH",1.52578373592374,0.730487055782084,TRUE
+"HCC44","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.31717,-0.931,0.574,11672,0.973,"GUCY1A2, ACTG2, PLA2G10, ADCY5, MAP2K1, PRKCD, ARAF, ARHGEF12, PRKG1, PRKCG, GUCY1A1, CACNA1D, RHOA, RAMP2, PRKCQ, CALML6, ADRA1B, MYH11, KCNMA1, KCNMB4, PRKACA, MYL6B, GUCY1B1, CALM1, PLCB4, PPP1CC, GNA11, KCNMB3, ADCY6, MAPK1, NPR2, ACTA2, ARHGEF11, ADCY9, PPP1R12B, MYL6, CALM2, PLA2G4B, PLA2G6, GNAQ, PRKX, PPP1CB, MAPK3, CALM3, PLA2G12A, PPP1CA, PLCB3",0.241088107602027,0.0118871597316481,FALSE
+"HCC44","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.55176,-1.61,0.0128,13038,0.128,"DCTN4, DCTN6, RAB5A, VAMP2, DYNLL2, PRKACA, DYNC1I1, ADCY6, ARHGDIB, RAB5C, CREB1, ADCY9, RAB11B, DCTN5, ARHGDIA, STX4, CREB3L4, DYNLL1, DCTN2, DYNC2LI1, PRKX, CREB3, DCTN1, DYNC1I2, RAB5B, RAB11A",1.89279003035213,0.892790030352132,TRUE
+"HCC44","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32871,-0.973,0.502,13572,0.904,"SHC2, AKT1, NFATC3, PIK3R1, MAPK14, PTK2, NOS3, CDC42, MAPK1, NFATC4, PPP3CB, PPP3CC, PLCG2, HSPB1, PIK3CA, KRAS, PLA2G4B, CHP1, PLA2G6, MAPK11, SRC, PLCG1, SPHK2, HRAS, MAPK3, PIK3R2, PLA2G12A, BAD",0.299296282854981,0.0438315695246367,FALSE
+"HCC44","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.47245,-1.38,0.0679,14098,0.282,"PRKACA, ATP6V0D1, ARF1, ATP6V0B, ATP6V1G1, ATP6V0A1, ATP6V1G2, ATP6V1B1, ATP6V0E2, PLCG2, ATP6V1A, ATP6V1H, ATP6V0C, ADCY9, SEC61A2, ATP6V1B2, ATP6V1E1, ATP6V0E1, ATP6V1E2, PLCG1, ATP6V1C1, PRKX, ATP6V1F",1.1681302257195,0.549750891680639,FALSE
+"HCC44","Input","KEGG_VIRAL_MYOCARDITIS",0.24298,0.915,0.652,2365,0.807,"ITGB2, ICAM1, RAC2, CD55, ABL2, EIF4G1, CD40, EIF4G3, MYH9, CYCS",0.18575240426808,0.0931264652779296,FALSE
+"HCC44","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.32111,-0.948,0.548,10108,0.942,"PPP3R2, PPP3CA, DAAM1, WNT11, WNT2B, PRKCA, CAMK2A, LRP5, PPARD, NKD1, MAPK8, ROCK1, PLCB2, PRICKLE2, FZD5, WNT9A, APC2, CSNK1A1, SIAH1, PPP2R5C, LRP6, WNT7A, CXXC4, WNT6, PPP2R5E, FZD8, WNT4, VANGL2, TCF7L2, CCND2, FZD3, CSNK2A1, FRAT2, DAAM2, PRKCG, CAMK2B, WNT10A, RAC3, FZD7, CREBBP, RHOA, SFRP1, AXIN2, WNT10B, NFATC3, CTBP2, PRKACA, MAPK10, PPP2CB, PLCB4, FBXW11, FZD4, CCND3, LEF1, PPP2R1B, TBL1XR1, NFATC4, DVL3, PPP3CB, APC, PPP3CC, FZD2, MAPK9, CAMK2D, SKP1, PPP2R5A, FRAT1, GSK3B, AXIN1, PPP2CA, TCF7L1, PPP2R1A, CAMK2G, DVL2, CACYBP, CHP1, PRKX, CTNNBIP1, BTRC, CTBP1, TP53, PPP2R5B, RBX1, PLCB3, PPP2R5D",0.261219441515631,0.0259490972071227,FALSE
+"A549","Input","KEGG_ABC_TRANSPORTERS",0.2741,0.996,0.429,1809,0.627,"ABCG2, ABCC2, ABCC1, ABCC4, ABCC3, ABCD3, ABCB10",0.367542707815276,0.202732459169284,FALSE
+"A549","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.36552,-1.31,0.133,16954,0.839,"BRAF, LEF1, PIK3CA, AKT1, RUNX1, PIK3R3, MAPK3, MTOR, PPARD, PML, PIK3R2",0.876148359032914,0.0762380391712997,FALSE
+"A549","Input","KEGG_ADHERENS_JUNCTION",0.2964,1.08,0.312,2211,0.56,"PARD3, ACP1, SRC, TGFBR1, TJP1, PTPRJ, IGF1R, ACTG1, ACTN4, PTPRM, VCL, SMAD3, RHOA, SNAI1, SMAD2, NECTIN3, MET, CSNK2A1, FGFR1",0.505845405981557,0.2518119729938,FALSE
+"A549","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.20579,0.754,0.815,3746,0.906,"PRKCQ, TRAF2, TNFRSF1A, STAT3, AKT2, CHUK, ACSL3, NFKBIB, ADIPOR2, AKT3, PTPN11, PRKAA2, CAMKK1, CPT1C, ACACB, MAPK9, MAPK8",0.0888423912600234,0.0428718023231869,FALSE
+"A549","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.30172,-1.06,0.324,16316,0.637,"GLS2, ABAT, GLUL, GPT, ASS1, IL4I1, ASL, GAD1, GPT2",0.489454989793388,0.19586056766465,FALSE
+"A549","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.27822,-0.984,0.426,15843,0.72,"NR3C2, PIK3R1, INSR, PIK3CA, ATP1A1, PIK3R3, MAPK3, PIK3R2",0.370590400897281,0.142667503568732,FALSE
+"A549","Input","KEGG_ALLOGRAFT_REJECTION",0.58561,2.12,0.00439,6,0.0847,"IL5",2.35753547975788,1.07211658966929,TRUE
+"A549","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.31057,-1.12,0.288,17771,0.7,"PLA2G12A, PLA2G6, PLA2G4B",0.540607512240769,0.154901959985743,FALSE
+"A549","Input","KEGG_ALZHEIMERS_DISEASE",0.19008,0.685,0.916,2930,0.921,"GRIN2B, ATP2A2, UQCRFS1, CALM2, TNFRSF1A, PSENEN, COX6B1, IDE, PLCB4, CHP1, NAE1, ATP5F1B, ATP5MC1, PPP3R1, CAPN2, NDUFB10, ADAM17, ATP5F1C, CASP8, GRIN2D, PSEN2, PPP3CA, APAF1, PSEN1, NDUFA9, ADAM10, ATP5MC3, GAPDH, FAS",0.0381045263321496,0.0357403698031511,FALSE
+"A549","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.40949,1.48,0.0722,1993,0.318,"EARS2, MTFMT, IARS2, YARS2, FARSB, DARS2, NARS2, SARS2",1.14146280243036,0.497572880015567,FALSE
+"A549","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.30292,-1.07,0.332,15267,0.646,"GMPPB, GNPDA1, RENBP, PMM1, GALE, GMPPA, CYB5R1, GALT, UAP1, PGM2, NPL, CYB5R3, GMDS, AMDHD2, HK2",0.478861916295964,0.189767482004916,FALSE
+"A549","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.31316,1.14,0.243,3073,0.516,"GRIN2B, TNFRSF1A, TOMM40, CHP1, PPP3R1, MAP2K6, GRIN2D, PPP3CA, APAF1, DERL1, BCL2L1, CYCS",0.614393726401688,0.287350298372789,FALSE
+"A549","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.22718,0.849,0.684,1332,0.743,"IFNA13, HSPA2, PSME3, CTSL, HSPA4, HSP90AA1",0.164943898279884,0.129011186239425,FALSE
+"A549","Input","KEGG_APOPTOSIS",0.34892,1.28,0.16,3073,0.435,"MAP3K14, TRAF2, TNFRSF1A, AIFM1, CFLAR, IL1R1, AKT2, TNFRSF10D, CHP1, BIRC3, PRKX, PPP3R1, TNFRSF10A, CHUK, TNFRSF10B, CAPN2, IRAK2, CASP8, AKT3, PPP3CA, APAF1, EXOG, FAS, BCL2L1, TNFRSF10C, CYCS",0.795880017344075,0.361510743045363,FALSE
+"A549","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.26509,0.956,0.464,885,0.693,"AKR1C3, GPX2, GGT1, CYP4F3, LTA4H, PLA2G4A",0.333482019445119,0.159266765388193,FALSE
+"A549","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.29593,1.07,0.351,793,0.561,"P4HA3, AGMAT, ALDH3A2, AMD1, GLS, ALDH1B1, GOT2",0.454692883534176,0.251037138743839,FALSE
+"A549","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.36983,1.36,0.128,1975,0.396,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, ITGA11, GJA1, ACTG1, ACTN4, ITGB5, SGCA, CDH2, CACNG8",0.892790030352132,0.402304814074488,FALSE
+"A549","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.63856,2.3,0.0022,739,0.104,"UGDH, ALDH3A2, ALDH1B1",2.65757731917779,0.98296666070122,TRUE
+"A549","Input","KEGG_ASTHMA",0.61896,2.28,0.00223,6,0.0807,"IL5",2.65169513695184,1.09312646527793,TRUE
+"A549","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.56491,2.03,0.00622,29,0.0981,"IL5, IFNA13",2.20620961530918,1.00833099262005,TRUE
+"A549","Input","KEGG_AXON_GUIDANCE",-0.34891,-1.28,0.146,14908,0.812,"RAC3, EPHB1, UNC5A, NFATC1, CXCR4, PLXNC1, NTNG1, SEMA6D, SEMA3F, ABLIM2, EFNB3, SRGAP3, SEMA3D, SEMA6C, EPHB6, EPHA4, EFNA4, PLXNB2, SEMA6A, ARHGEF12, NTN1, EFNA3, SEMA5A, SEMA7A, SLIT2, NCK2, PLXNA2, EFNB1, SEMA3B, UNC5B, LIMK1, SEMA4A, ROBO3, PLXNB3, PAK6, EPHA1, PAK2, PLXNA1, EPHB3, MAPK3, NFATC4, SEMA4C, RAC2, PLXNB1, EFNB2, FYN, SRGAP2, LIMK2, GNAI2, PLXNA3",0.835647144215563,0.0904439707588247,FALSE
+"A549","Input","KEGG_BASAL_CELL_CARCINOMA",-0.31089,-1.12,0.273,15378,0.7,"AXIN2, FZD7, AXIN1, DVL2, WNT10A, DVL1, PTCH1, WNT2B, SUFU, STK36, BMP2, LEF1, WNT5A, FZD4, FZD1, GLI3, DVL3",0.563837352959244,0.154901959985743,FALSE
+"A549","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.39787,-1.43,0.0967,16587,0.866,"STON1, TAF1, TAF13, GTF2B, TAF4, GTF2H2, TAF11, TAF12, TAF6L, GTF2H4, GTF2IRD1",1.014573525917,0.0624821079826534,FALSE
+"A549","Input","KEGG_BASE_EXCISION_REPAIR",0.34063,1.25,0.161,3558,0.45,"NEIL3, TDG, UNG, PCNA, POLE4, LIG3, POLE2, APEX2, POLD4, NEIL2, POLE3, APEX1",0.79317412396815,0.346787486224656,FALSE
+"A549","Input","KEGG_BETA_ALANINE_METABOLISM",0.3133,1.14,0.253,3467,0.516,"ALDH3A2, ALDH1B1, HADHA, HIBCH, ALDH2, ECHS1",0.596879478824182,0.287350298372789,FALSE
+"A549","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.64676,2.35,0,2949,0.154,"BAAT, ELOVL2, HACD2, HACD1, FADS2, ACOT1, PECR, HADHA, ACOT2, FADS1, YOD1, HSD17B12",Inf,0.812479279163537,TRUE
+"A549","Input","KEGG_BLADDER_CANCER",-0.31765,-1.14,0.25,16340,0.722,"RPS6KA5, MMP1, E2F2, BRAF, RASSF1, MAPK3, CDKN2A, VEGFA, VEGFB",0.602059991327962,0.141462802430361,FALSE
+"A549","Input","KEGG_BUTANOATE_METABOLISM",0.24206,0.884,0.566,2903,0.713,"AKR1B10, ALDH3A2, ALDH1B1, HADHA, ACSM3, ALDH2, HMGCS1",0.247183568811729,0.146910470148134,FALSE
+"A549","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26891,-0.975,0.438,14885,0.699,"BLNK, RAC3, VAV2, CD72, NFATC1, JUN, CD22, DAPP1, PIK3R1, BCL10, SYK, PIK3CA, AKT1, PIK3R3, MAPK3, IFITM1, NFATC4, RAC2, FOS, PIK3R2",0.3585258894959,0.155522824254319,FALSE
+"A549","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2841,1.05,0.367,3051,0.562,"CD38, ATP2A2, CACNA1G, BST1, PHKA1, PLCE1, VDAC1, CALM2, VDAC2, ATP2B1, VDAC3, ADRA1B, GNAL, PLCB4, CHP1, TRPC1, PDE1A, PDE1C, PRKX, PPP3R1, CACNA1H, AGTR1, PLCD3, HRH2, P2RX5, PRKCA, PPID, OXTR, PHKB, GRIN2D, PPP3CA, CAMK2D, HTR2B, SLC25A5, RYR1, ADRA1D",0.435333935747911,0.250263684430939,FALSE
+"A549","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.28927,1.06,0.326,1190,0.552,"ATP2A2, UQCRFS1, CACNG7, FXYD2, CACNA2D1, CACNG6, COX6B1, TPM1, TPM2, ATP1B1",0.486782399932061,0.258060922270801,FALSE
+"A549","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.2094,0.759,0.808,2687,0.906,"CNTN1, NRCAM, ITGAV, ESAM, ITGAM, CDH4, ITGB1, PVR, PTPRM, CDH2, MPZL1, NEO1, NECTIN3, CLDN1, CLDN2, CADM1, CLDN23, SDC1",0.0925886392254138,0.0428718023231869,FALSE
+"A549","Input","KEGG_CELL_CYCLE",0.24874,0.921,0.548,3925,0.686,"YWHAQ, CCND3, ORC4, ORC2, TGFB2, CDC27, ORC5, SMAD3, PCNA, ANAPC5, SMC3, CUL1, MCM6, SMAD2, RBL1, CCNE1, CCNB1, CCNB3, SFN, YWHAG, CDKN1A, CCNB2, SKP1, CDC23, CDC6, PRKDC, CDC26, ORC1, BUB1, PLK1, ANAPC7, SMAD4, STAG2, ANAPC1, CDK1, YWHAB, CDK7, GADD45B, ANAPC11, E2F5, SMC1A, YWHAZ, TTK",0.261219441515631,0.163675884293248,FALSE
+"A549","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.18309,-0.661,0.943,14653,0.951,"ADCY4, GNGT1, XCL1, GNB1, VAV2, JAK3, GRK7, BCAR1, CCL5, CXCR4, PRKCD, GNG13, PLCB2, SHC4, PLCB1, SHC3, GNB2, CCL27, GNG7, GNB3, CX3CL1, PIK3R1, RAP1A, PLCB3, SHC2, CCR10, CCL28, BRAF, PIK3CA, AKT1, PRKACA, CRKL, PIK3R3, TIAM2, MAPK3, GRK6, RAC2, GRK4, TIAM1, GRK2, STAT2, GNAI2, FOXO3, PIK3R2",0.0254883072626717,0.0218194830625861,FALSE
+"A549","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.33335,-1.2,0.211,15325,0.818,"SHC4, GAB2, SHC3, CBLC, CBL, PIK3R1, HDAC1, SHC2, E2F2, TGFB3, BRAF, PIK3CA, AKT1, CDKN1B, CRKL, RUNX1, PIK3R3, MAPK3, CDKN2A, MECOM, CTBP1, BCR, PIK3R2",0.675717544702307,0.087246696328677,FALSE
+"A549","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.54545,-1.96,0.00348,15631,0.362,"CLOCK, CSNK1D, PER1, BHLHE41, CRY2, PER3, NR1D1, CSNK1E",2.45842075605342,0.441291429466834,FALSE
+"A549","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29894,1.09,0.296,4429,0.561,"ACLY, IDH3A, DLD, PC, SUCLG1, MDH1, IDH1, IDH3B, SUCLA2, SDHC, ACO1, CS",0.528708288941061,0.251037138743839,FALSE
+"A549","Input","KEGG_COLORECTAL_CANCER",-0.26368,-0.947,0.469,14908,0.707,"RAC3, MAPK10, JUN, AXIN2, AXIN1, PIK3R1, BCL2, TGFB3, BRAF, LEF1, PIK3CA, AKT1, PIK3R3, MAPK3, RAC2, RALGDS, FOS, PIK3R2",0.328827157284917,0.150580586203101,FALSE
+"A549","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.46565,1.71,0.0252,2571,0.241,"FGA, C5, FGB, FGG, PLG, F2, SERPINE1, PROC, C1S, C4BPA, C4BPB, THBD, F13B, CD59, C5AR1, CFH",1.59859945921846,0.617982957425132,TRUE
+"A549","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.30639,1.12,0.283,2736,0.544,"AMD1, GOT2, LDHA, TRDMT1, LDHB, DNMT3B, ADI1, MAT2A, SDS",0.54821356447571,0.26440110030182,FALSE
+"A549","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20573,0.749,0.822,3249,0.887,"IL5, IFNA13, CXCL5, BMPR1B, EDA2R, IL15, TNFRSF1A, TGFBR1, CCL2, CCR7, TGFB2, IL18, CCL26, BMPR1A, IL1R1, TNFRSF10D, IL11, IL13RA1, INHBB, TNFRSF10A, IFNE, CLCF1, TNFRSF10B, PF4, MET, TNFRSF9, FLT4, AMHR2, IL18R1, BMPR2, VEGFD, IL6ST, CSF2RA, TNFSF12, TGFBR2, IFNAR2, TNFSF15, FAS, TNFRSF10C, IL22RA1, TNFSF9, OSMR, EGFR",0.0851281824599496,0.0520763801682736,FALSE
+"A549","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26521,0.954,0.471,2989,0.678,"IFNA13, TBK1, IL18, CHUK, PYCARD, NFKBIB, POLR3K, POLR3G, POLR3F, POLR3D",0.326979092871104,0.168770306132937,FALSE
+"A549","Input","KEGG_DILATED_CARDIOMYOPATHY",0.3531,1.28,0.141,1975,0.435,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, TGFB2, TPM1, ITGA11, TPM2, ACTG1, PRKX, ITGB5, SGCA, TPM4, CACNG8",0.85078088734462,0.361510743045363,FALSE
+"A549","Input","KEGG_DNA_REPLICATION",0.43957,1.61,0.051,4206,0.242,"PRIM1, RNASEH1, RFC5, PCNA, RPA1, POLE4, MCM6, POLE2, POLA1, POLD4, DNA2, RNASEH2B, RFC3, SSBP1, POLE3, FEN1, MCM4",1.29242982390206,0.616184634019569,FALSE
+"A549","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.30842,-1.1,0.291,15132,0.665,"SPIRE1, NOTCH2, PIWIL4, NOTCH1, ETV7, NOTCH4, MAPK3",0.536107011014093,0.177178354696895,FALSE
+"A549","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.12039,0.444,1,1539,1,"ALDH3A1, MGST1, ALDH3B1",0,0,FALSE
+"A549","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.27049,0.976,0.454,2345,0.66,"CES1, UMPS, CDA, UCK2, GMPS, CES5A, HPRT1",0.342944147142896,0.180456064458131,FALSE
+"A549","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.20132,0.75,0.827,961,0.895,"VTN, COL4A4, ITGAV, COL5A2, SPP1, ITGB1, COL4A6, ITGA11",0.0824944904474534,0.048176964684088,FALSE
+"A549","Input","KEGG_ENDOCYTOSIS",-0.20255,-0.729,0.857,14554,0.898,"CSF1R, EPS15, KIT, SH3GL3, EHD4, ARFGAP3, IQSEC1, GRK7, CXCR4, CHMP4B, FGFR3, LDLR, ACAP2, ADRB2, EPN3, ARFGAP1, AGAP2, CBLC, PARD6A, CBL, ASAP3, VPS28, RAB11FIP4, RAB11FIP3, HGS, LDLRAP1, RAB5B, AP2A1, FGFR2, SH3GLB2, AP2M1, VPS4A, RAB22A, PSD, RAB11B, ARAP2, VPS37C, ARAP1, GRK6, SH3GL1, VPS37B, MVB12A, SMAP2, GRK4, ACAP3, GRK2, PIP5K1C, DNM2, ARFGAP2",0.0670191780768018,0.0467236633326956,FALSE
+"A549","Input","KEGG_ENDOMETRIAL_CANCER",-0.34472,-1.26,0.174,15378,0.772,"AXIN2, AXIN1, ELK1, PIK3R1, BRAF, LEF1, PIK3CA, AKT1, PIK3R3, MAPK3, FOXO3, PIK3R2",0.7594507517174,0.112382699664264,FALSE
+"A549","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23325,0.859,0.654,3746,0.739,"ATP6V1E2, MAP3K14, MAP2K4, SRC, TJP1, CHUK, ATP6V0E1, MET, ADAM17, PTPN11, LYN, ADAM10, EGFR, ATP6V0E2, ATP6V1C1, MAPK9, MAPK8",0.184422251675733,0.131355561605174,FALSE
+"A549","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.26041,-0.931,0.497,14851,0.73,"HBEGF, CAMK2B, MAPK10, JUN, RPS6KB2, SHC4, SHC3, CBLC, ELK1, CBL, PIK3R1, SHC2, BRAF, PIK3CA, AKT1, NCK2, GAB1, CDKN1B, CRKL, PAK6, PAK2, PLCG1, PIK3R3, MAPK3, MTOR, MAP2K7, PIK3R2",0.303643611266668,0.136677139879544,FALSE
+"A549","Input","KEGG_ETHER_LIPID_METABOLISM",0.25985,0.935,0.508,3570,0.71,"CHPT1, PLA2G4A, PAFAH1B1, PLPP1, PAFAH1B3, AGPS, PLPP2, LPCAT2",0.294136287716081,0.148741651280925,FALSE
+"A549","Input","KEGG_FATTY_ACID_METABOLISM",-0.20678,-0.732,0.848,16436,0.906,"ACADVL, ECI1, ACSL5, HADH, GCDH, CPT2",0.0716041477432862,0.0428718023231869,FALSE
+"A549","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.25351,-0.883,0.575,14908,0.773,"RAC3, VAV2, MAPK10, PRKCD, GAB2, MAPK12, PIK3R1, SYK, MAPK14, PIK3CA, AKT1, PLA2G12A, LAT, PLCG1, PIK3R3, PLA2G6, MAPK3, PLA2G4B, RAC2, MAPK13, FYN, MAP2K7, PIK3R2",0.24033215531037,0.111820506081675,FALSE
+"A549","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.29224,-1.05,0.353,17036,0.644,"MARCKS, PIK3CA, ARPC5L, AKT1, LIMK1, CRKL, LAT, PLCG1, PIK3R3, WASF3, PLA2G6, MAPK3, PLA2G4B, RAC2, PIP5K1C, LIMK2, DNM2, WASF2, PIK3R2",0.452225294612177,0.191114132640188,FALSE
+"A549","Input","KEGG_FOCAL_ADHESION",0.23857,0.877,0.596,4730,0.719,"PDGFD, VTN, ROCK2, FLNB, COL4A4, CCND3, ITGAV, COL5A2, SRC, CRK, SPP1, ITGB1, COL4A6, PPP1CC, VAV1, ARHGAP5, ITGA11, AKT2, BIRC3, IGF1R, ACTG1, ACTN4, ITGB5, VCL, CAV1, RHOA, CAPN2, CAV2, RAP1B, PRKCA, HRAS, MET, COL4A1, FLT4, AKT3, COL5A1, ACTB, VEGFD, PPP1R12A, COL4A2, LAMC2, EGFR, COL11A1, PPP1CB, SOS1, PTK2, MAP2K1, ILK, ACTN1, VAV3, FLNA, MAPK9, MAPK8, PXN, ITGB6, LAMC1, DOCK1, ITGA2B, SOS2, FN1, ROCK1, ITGA5, LAMC3, LAMB1, LAMB4, ZYX, VEGFC, LAMA5, ITGA3, PARVA, MYL2, CTNNB1, ARHGAP35, PIK3CB",0.224753740259764,0.143271109617117,FALSE
+"A549","Input","KEGG_FOLATE_BIOSYNTHESIS",0.29043,1.08,0.303,179,0.56,"SPR",0.518557371497695,0.2518119729938,FALSE
+"A549","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.29031,1.04,0.359,1301,0.564,"AKR1B10, PFKFB3, AKR1B1, PMM2, PFKP",0.444905551421681,0.248720896016658,FALSE
+"A549","Input","KEGG_GALACTOSE_METABOLISM",0.29664,1.07,0.32,1897,0.561,"GLA, AKR1B1, B4GALT1, UGP2, PFKP, MGAM, GALK1",0.494850021680094,0.251037138743839,FALSE
+"A549","Input","KEGG_GAP_JUNCTION",0.25132,0.907,0.569,4331,0.69,"PDGFD, TUBA4A, SRC, TJP1, PLCB4, GJA1, PRKX, MAP3K2, TUBAL3, PRKCA, HRAS, TUBA1C, TUBA1B, HTR2B, PRKG2, LPAR1, EGFR, SOS1, CDK1, TUBB4A, MAP2K1, TUBB4B, GNAI1, DRD1, TUBB3, KRAS, SOS2, TUBA1A, ADRB1",0.244887733604929,0.161150909262745,FALSE
+"A549","Input","KEGG_GLIOMA",-0.28577,-1.01,0.418,15006,0.721,"CAMK2B, SHC4, SHC3, PDGFRB, CALML6, PIK3R1, SHC2, E2F2, BRAF, PIK3CA, AKT1, PLCG1, PIK3R3, MAPK3, CDKN2A, MTOR, PIK3R2",0.378823718224965,0.142064735280571,FALSE
+"A549","Input","KEGG_GLUTATHIONE_METABOLISM",0.4543,1.68,0.0414,2898,0.252,"PGD, G6PD, GPX2, GSR, GCLM, GCLC, GGT1, MGST1, RRM2B, IDH1, RRM1, MGST2, GPX3",1.3829996588791,0.598599459218456,FALSE
+"A549","Input","KEGG_GLYCEROLIPID_METABOLISM",0.34439,1.27,0.148,3410,0.44,"GLA, LCLAT1, DGKG, AKR1B1, ALDH3A2, ALDH1B1, DGKD, GPAT3, AGK, PLPP1, ALDH2, GPAT4, MBOAT2, PLPP2, MGLL",0.829738284605043,0.356547323513813,FALSE
+"A549","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.2477,0.916,0.555,2061,0.687,"LCLAT1, CDS2, DGKG, CHPT1, CRLS1, PLA2G4A, DGKD, LPGAT1, GPAT3, GPD1L, ETNK1, GNPAT, PTDSS1, PLPP1",0.255707016877324,0.16304326294045,FALSE
+"A549","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.25122,-0.907,0.565,15637,0.759,"SARDH, GNMT, DMGDH, CTH, SHMT2, AMT, GCAT",0.247951552180562,0.11975822410452,FALSE
+"A549","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.32423,1.17,0.222,2953,0.502,"ALDH3A1, ENO3, GPI, ALDH3A2, ALDH1B1, LDHA, GALM, PFKP, ALDH3B1, DLD, LDHB, TPI1, PKM, ALDH2, PGAM1, GAPDH, ENO1",0.653647025549361,0.299296282854981,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.30104,-1.08,0.292,15581,0.675,"B3GAT3, CHSY3, CHST14, B3GALT6, CHST12, B4GALT7, UST, CHPF",0.534617148551582,0.170696227168975,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.50018,-1.8,0.0142,12935,0.504,"EXTL1, HS6ST3, EXTL2, HS3ST5, NDST3, HS3ST3B1, EXTL3, B3GAT1, EXT1, HS3ST1, XYLT2, B3GAT3, B3GALT6, HS3ST3A1, HS6ST2, HS6ST1, B4GALT7, NDST2",1.84771165561694,0.297569463554475,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.2953,-1.06,0.328,15219,0.637,"CHST6, B4GAT1, CHST2, B4GALT2, B4GALT3, ST3GAL3",0.484126156288321,0.19586056766465,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.47606,-1.69,0.0289,16275,0.614,"HS3ST3A1, SGSH, HYAL2, IDUA, GUSB",1.53910215724345,0.211831628858832,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.34925,-1.24,0.185,13218,0.784,"ST6GALNAC4, ST8SIA5, ST3GAL1, HEXB, SLC33A1, ST6GALNAC6, ST6GALNAC5, B3GALT4",0.732828271596986,0.105683937315562,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.36646,-1.31,0.127,13444,0.839,"FUT9, ST3GAL1, HEXB, B3GALT5, FUT2, FUT1, B3GALNT1, NAGA",0.896196279044043,0.0762380391712997,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.31284,-1.14,0.229,13041,0.722,"FUT7, FUT9, ABO, FUT4, ST3GAL4, B3GALT1, B3GALT5, ST3GAL6, B4GAT1, FUT2, FUT3, FUT1, B4GALT2, B3GNT4, B4GALT3, ST3GAL3",0.640164517660112,0.141462802430361,FALSE
+"A549","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.29279,1.06,0.333,4601,0.552,"PIGB, PIGO, PIGF, PIGW, PIGA, PIGN, PIGH, GPLD1, PIGU, PIGC, PIGL, PIGX",0.47755576649368,0.258060922270801,FALSE
+"A549","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.30715,1.1,0.29,4623,0.552,"MDH1, MTHFD2, AFMID, MTHFD1, PGP, ACO1, CS, MTHFD2L",0.537602002101044,0.258060922270801,FALSE
+"A549","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.27279,-0.968,0.444,14653,0.701,"ADCY4, HBEGF, CACNA1C, CAMK2B, MAPK10, JUN, PRKCD, PLCB2, PLCB1, CALML6, MAPK12, ELK1, GNAS, ITPR3, MAP3K3, PLCB3, MAPK14, LHB, GNA11, PRKACA, MAP3K1, PLA2G12A, ATF4, MAP3K4, PLA2G6, MAPK3, PLA2G4B, MAPK13, MMP14, MAP2K7",0.35261702988538,0.154281982033341,FALSE
+"A549","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.2782,-0.991,0.428,8202,0.718,"KIR2DL1, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, KLRC1, CD86, GZMB, TNF, IL1A, IL6, IL1B",0.368556230986828,0.1438755557577,FALSE
+"A549","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.25644,-0.91,0.549,15926,0.765,"CSNK1D, WNT10A, GAS1, BMP7, PTCH1, WNT2B, SUFU, STK36, BMP2, WNT5A, PRKACA, GLI3, CSNK1G2, CSNK1E",0.260427655549908,0.116338564846382,FALSE
+"A549","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.25929,0.927,0.499,1152,0.682,"IL5, CD38, ITGAM, IL1R1, IL11",0.30189945437661,0.166215625343521,FALSE
+"A549","Input","KEGG_HISTIDINE_METABOLISM",0.4112,1.48,0.071,2752,0.318,"ALDH3A1, AMDHD1, ALDH3A2, ALDH1B1, ALDH3B1, METTL6, METTL2B, BUD23, ALDH2",1.14874165128092,0.497572880015567,FALSE
+"A549","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.33074,1.21,0.204,3298,0.474,"RAD50, RAD51C, NBN, RPA1, RAD54B, BLM, POLD4, RAD51D, SSBP1",0.690369832574101,0.324221658325915,FALSE
+"A549","Input","KEGG_HUNTINGTONS_DISEASE",-0.2219,-0.799,0.729,14500,0.867,"TBP, NDUFA1, HDAC2, BBC3, GRIN1, NDUFS8, HTT, DNAH2, ATP5PB, PLCB2, DNALI1, PLCB1, NDUFA2, NDUFV3, UQCRB, NDUFA5, CREB3L1, SDHD, COX8A, COX7C, POLR2J, CREB3L2, UQCR10, SP1, EP300, HDAC1, ATP5PO, PLCB3, PPARGC1A, AP2A1, NDUFA3, DNAH1, NDUFA6, AP2M1, POLR2F, NDUFS6, TAF4, CREBBP, CREB3L4, NDUFC1, UQCRHL, CREB5, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, NDUFS7, DNAL4, NDUFV1, POLR2H, COX5B",0.137272471682025,0.0619809025237897,FALSE
+"A549","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.35307,1.29,0.147,1975,0.457,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, TGFB2, TPM1, ITGA11, TPM2, ACTG1, ITGB5, SGCA, TPM4, CACNG8",0.832682665251824,0.34008379993015,FALSE
+"A549","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.32577,-1.19,0.213,15324,0.807,"PLCB2, PLCB1, INPP5J, PLCB3, ITPKB, PIK3CA, INPP5B, ITPKA, PI4KB, SYNJ1, PLCG1, INPPL1, INPP5E, PI4KA, ALDH6A1, PIP5K1C",0.671620396561262,0.0931264652779296,FALSE
+"A549","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.26916,-0.979,0.44,15123,0.717,"MAPK10, GYS1, FASN, PYGM, RPS6KB2, SHC4, SHC3, PHKG1, PHKA2, CALML6, CBLC, ELK1, CBL, PIK3R1, MKNK1, PPP1R3D, SHC2, PPARGC1A, INSR, BRAF, PIK3CA, AKT1, FLOT1, TSC1, SORBS1, MKNK2, PRKACA, CRKL, SOCS1, SH2B2, PIK3R3, PTPN1, MAPK3, MTOR, TSC2, PIK3R2, HK2",0.356547323513813,0.1444808443322,FALSE
+"A549","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.38221,1.38,0.112,445,0.38,"IL5, MAP3K14, IL15",0.950781977329818,0.42021640338319,FALSE
+"A549","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.20203,0.734,0.834,3248,0.887,"IL5, STAT4, IFNA13, CCND3, SOCS5, JAK1, IL15, STAT3, AKT2, IL11, IL13RA1, IFNE, CLCF1, STAT1, AKT3, PTPN11, IL6ST, CSF2RA, PIAS1, IFNAR2, BCL2L1, STAM, SOCS4, STAM2, IL22RA1, OSMR",0.0788339493622613,0.0520763801682736,FALSE
+"A549","Input","KEGG_LEISHMANIA_INFECTION",-0.24077,-0.886,0.606,13721,0.779,"TNF, MAPK11, MARCKSL1, TAB2, IL1A, ITGA4, FCGR2A, JUN, IFNGR2, IL1B, MAPK12, ELK1, TLR4, TLR2, MAPK14, ITGB2, TGFB3, MAPK3, MAPK13, TAB1, FOS",0.217527375833714,0.108462542327436,FALSE
+"A549","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.20889,-0.742,0.844,14723,0.901,"ITGA4, SIPA1, JAM2, VAV2, BCAR1, CLDN20, CXCR4, CLDN11, CLDN22, CLDN9, CLDN4, RAPGEF4, MAPK12, MYLPF, PIK3R1, RAP1A, RASSF5, TXK, MAPK14, ITGB2, RAPGEF3, PIK3CA, CLDN7, ICAM1, AFDN, PLCG1, PIK3R3, RAC2, MAPK13, MYL5, GNAI2, PIK3R2",0.073657553374345,0.045275209020937,FALSE
+"A549","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.56669,2.04,0.00671,3467,0.107,"ALDH3A2, ALDH1B1, HADHA, ALDH2, YOD1, ECHS1",2.17327747983101,0.97061622231479,TRUE
+"A549","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.24918,0.893,0.588,885,0.702,"AKR1B10, PLA2G4A",0.230622673923862,0.153662887870195,FALSE
+"A549","Input","KEGG_LONG_TERM_DEPRESSION",-0.19783,-0.72,0.856,14941,0.9,"GUCY1B1, PRKG1, PLCB2, PLCB1, GUCY1A1, GNAS, ITPR3, GNAO1, PLCB3, BRAF, GNA11, PLA2G12A, PLA2G6, MAPK3, PLA2G4B, GNAI2",0.0675262353228468,0.0457574905606751,FALSE
+"A549","Input","KEGG_LONG_TERM_POTENTIATION",0.31951,1.15,0.269,2778,0.528,"GRIN2B, CALM2, RPS6KA3, RPS6KA6, PPP1CC, PLCB4, CHP1, PRKX, PPP3R1, RAP1B, PRKCA, HRAS, GRIN2D, PPP3CA, CAMK2D, PPP1R12A",0.570247719997592,0.277366077466188,FALSE
+"A549","Input","KEGG_LYSINE_DEGRADATION",-0.36247,-1.27,0.158,17133,0.791,"KMT5C, OGDHL, KMT5B, SETDB2, PLOD3, OGDH, SETD1B, HADH, DOT1L, AASS, EHMT2, GCDH",0.801342913045577,0.101823516502323,FALSE
+"A549","Input","KEGG_LYSOSOME",-0.3232,-1.16,0.243,16365,0.784,"CD164, AP3B2, MANBA, ACP5, ABCB9, TPP1, LAMP3, PPT1, AP4M1, SORT1, MCOLN1, CTSA, NEU1, SGSH, SMPD1, AP3D1, MAN2B1, ATP6V0B, CTSO, ARSG, LAMP1, ATP6V0C, IGF2R, IDUA, AP1B1, PPT2, GUSB, NAGA, GGA1, GNPTG",0.614393726401688,0.105683937315562,FALSE
+"A549","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.1989,0.716,0.849,2968,0.897,"CACNA1G, MAP3K14, FLNB, CACNG7, TRAF2, HSPA2, MAP2K4, RPS6KA3, PPM1B, TNFRSF1A, CACNA2D1, CACNG6, TGFBR1, CRK, MAP3K8, TGFB2, FGF2, RPS6KA6, PLA2G4A, IL1R1, ARRB2, AKT2, CHP1, DUSP1, PRKX, BDNF, PPP3R1, CHUK, MAP3K20, CACNA1H, MAP3K2, MAP2K6, NFKB2, RAP1B, CACNG8, PRKCA, TAOK1, HRAS, FGFR1, FGFR4, DUSP5, AKT3, HSPA8, PPP3CA, NF1, PPM1A, GNG12, HSPA1A, TGFBR2, CACNG4, FAS, RASGRP4, RRAS",0.0710923097560473,0.0472075569559079,FALSE
+"A549","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.62782,2.27,0,1038,0.0504,"NR5A2, HNF4A, FOXA2, HNF1A, HNF1B, HHEX",Inf,1.29756946355447,TRUE
+"A549","Input","KEGG_MELANOGENESIS",-0.2357,-0.839,0.675,14514,0.819,"WNT6, KIT, ADCY4, CAMK2B, PLCB2, PLCB1, FZD7, CREB3L1, DVL2, CALML6, MC1R, WNT10A, GNAS, CREB3L2, DVL1, EP300, GNAO1, PLCB3, WNT2B, LEF1, WNT5A, FZD4, PRKACA, CREBBP, CREB3L4, FZD1, MAPK3, GNAI2, DVL3",0.170696227168975,0.0867160982395816,FALSE
+"A549","Input","KEGG_MELANOMA",-0.23597,-0.847,0.668,15856,0.827,"PDGFRB, FGF22, PDGFC, PIK3R1, FGF12, E2F2, FGF13, BRAF, PIK3CA, AKT1, FGF11, PIK3R3, MAPK3, CDKN2A, PIK3R2",0.175223537524454,0.0824944904474534,FALSE
+"A549","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.40668,1.5,0.0635,1756,0.323,"AKR1C2, AKR1C3, ALDH3A1, AKR1C1, MGST1, CYP2S1, ALDH3B1, AKR1C4, EPHX1",1.19722627470802,0.490797477668897,FALSE
+"A549","Input","KEGG_MISMATCH_REPAIR",0.62679,2.27,0,3298,0.0504,"MSH6, MLH3, RFC5, PCNA, RPA1, EXO1, MSH2, MSH3, POLD4, MLH1, RFC3, SSBP1",Inf,1.29756946355447,TRUE
+"A549","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.35255,-1.28,0.165,15990,0.812,"MLST8, PIK3R1, STK11, BRAF, PIK3CA, AKT1, TSC1, PIK3R3, MAPK3, MTOR, VEGFA, TSC2, RPS6KA2, VEGFB, PIK3R2",0.782516055786094,0.0904439707588247,FALSE
+"A549","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.19789,-0.706,0.886,14362,0.909,"KLRK1, ULBP2, ULBP3, RAET1L, RAC3, VAV2, NFATC1, SHC4, SHC3, IFNGR2, ICAM2, PIK3R1, SYK, SHC2, HCST, ITGB2, BRAF, PIK3CA, TNFSF10, ICAM1, IFNAR1, LAT, PLCG1, PIK3R3, MAPK3, NFATC4, RAC2, FYN, SH3BP2, PIK3R2",0.0525662781129492,0.0414361167780325,FALSE
+"A549","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.25888,0.928,0.509,427,0.706,"NPY4R, GABRA5, GRIN2B, GLP2R, GABRB3, CHRNA5, HTR1D, PARD3, F2RL2, S1PR3, PLG, P2RY6",0.293282217663241,0.151195298948196,FALSE
+"A549","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.29635,-1.07,0.319,15006,0.646,"CAMK2B, MAPK10, RPS6KA1, JUN, PRKCD, SHC4, SHC3, CALML6, MAPK12, NGFR, MAPKAPK2, PIK3R1, RAP1A, RPS6KA5, MAP3K3, ARHGDIB, SHC2, MAPK14, BCL2, CAMK4, SORT1, BRAF, PIK3CA, AKT1, GAB1, CRKL, MAP3K1, ATF4, TP73, PLCG1, SH2B2, PIK3R3, MAPK3, SH2B1, SH2B3, MAPK13, RPS6KA2, MAP2K7, FOXO3, PIK3R2",0.496209316942819,0.189767482004916,FALSE
+"A549","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38506,1.41,0.0941,3284,0.379,"CD38, BST1, NAMPT, NT5C2, NNMT, PNP, AOX1, NT5C",1.02641037657274,0.421360790031928,FALSE
+"A549","Input","KEGG_NITROGEN_METABOLISM",0.28161,1.01,0.371,3214,0.606,"CA12, CA8, GLS, GLUD2, CPS1, GLUD1",0.430626090384954,0.217527375833714,FALSE
+"A549","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.22647,-0.799,0.737,12898,0.867,"MAP3K7, IKBKB, CXCL8, XIAP, MEFV, TRIP6, TNF, MAPK11, PSTPIP1, TAB2, NOD2, TAB3, NLRP3, MAPK10, CCL5, TNFAIP3, IL6, IL1B, MAPK12, CARD9, NLRP1, NAIP, MAPK14, CASP1, MAPK3, MAPK13, TAB1",0.132532512140949,0.0619809025237897,FALSE
+"A549","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.38921,1.41,0.0963,2998,0.379,"RAD50, NHEJ1, XRCC5, XRCC4, PRKDC",1.01637371287547,0.421360790031928,FALSE
+"A549","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.40776,-1.45,0.0783,16138,0.918,"PIK3R1, RASSF5, E2F2, BRAF, PIK3CA, RASSF1, AKT1, PLCG1, FHIT, PIK3R3, MAPK3, CDKN2A, FOXO3, RXRB, PIK3R2",1.10623823794206,0.0371573187987575,FALSE
+"A549","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.39712,-1.41,0.105,16295,0.83,"DVL1, EP300, HDAC1, DLL1, NOTCH1, DTX3L, RBPJ, MAML2, NOTCH4, CREBBP, HES1, MAML1, RFNG, CTBP1, NCSTN, APH1A, DVL3",0.978810700930062,0.0809219076239261,FALSE
+"A549","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.34276,1.23,0.183,3591,0.472,"DDB2, RFC5, PCNA, CETN2, ERCC8, RPA1, POLE4, ERCC1, ERCC4, POLE2, GTF2H1, POLD4, RFC3, MNAT1, ERCC3, CDK7, POLE3, XPC",0.737548910269571,0.326058001365912,FALSE
+"A549","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.26796,-0.949,0.474,12011,0.716,"ALG6, DPM1, ST6GAL1, MGAT5, STT3A, RPN2, ALG14, MAN2A2, DPM3, MGAT4B, MAN1A2, MGAT3, ALG3, ALG11, RPN1, GANAB, ALG12, DPM2, MAN1C1, MAN1B1, MGAT2, DDOST, B4GALT2, MOGS, MAN1A1, B4GALT3, MGAT1",0.324221658325915,0.145086977692144,FALSE
+"A549","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.21007,-0.763,0.78,6799,0.887,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, CNGA3, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR4C6, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR51E2, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, CAMK2A, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, CNGA4, OR3A2, OR5P2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR1M1, OR51B2, OR52D1, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, OR13D1, OR8D2, OR2T33, OR2S2, OR2A5, OR52H1, CALML3, OR52A1, OR1C1, OR1F1, OR14I1, OR5C1, OR1J4, OR2B11, CALML5, OR2T8, OR2C1, OR8G1, OR4F15, OR52B6, OR51B4, OR2A25, OR2D3, CAMK2G, OR10H1, OR8A1, OR1K1, OR2J3, OR10A6, OR2A2, OR8G5, OR4F3, OR11H4, OR10A4, GUCY2D, OR13A1, OR2A12, OR2D2, OR2H2, OR2AG1, OR10A3, OR2K2, OR7C1, OR10A2, OR7D2, OR2A14, OR13J1, OR4F16, CLCA2, OR2B6, OR4F17, OR2W3, OR2AG2, OR6A2, OR56B4, OR5K2, OR2A42, OR1L8, OR2AE1, OR10AD1, OR2A1, GUCA1B, OR52W1, OR52I1, CAMK2B, PRKG1, CALML6, OR2L2, OR2A7, PRKACA",0.10790539730952,0.0520763801682736,FALSE
+"A549","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.32718,1.19,0.207,728,0.487,"MTHFS, ATIC, MTFMT",0.684029654543082,0.312471038785366,FALSE
+"A549","Input","KEGG_OOCYTE_MEIOSIS",0.3606,1.32,0.125,3914,0.43,"YWHAQ, CALM2, RPS6KA3, RPS6KA6, PPP1CC, CDC27, CHP1, PPP2CB, IGF1R, SGO1, PRKX, PPP3R1, SLK, ANAPC5, SMC3, CUL1, AURKA, CCNE1, CCNB1, PPP3CA, CAMK2D, YWHAG, CCNB2, SKP1, CDC23, CDC26, BUB1, AR, PLK1, ANAPC7, ANAPC1, PPP2R5E, FBXW11, PPP1CB, CDK1, YWHAB, MAP2K1, ANAPC11, FBXO43, SMC1A, YWHAZ, PPP2R1A",0.903089986991944,0.366531544420413,FALSE
+"A549","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.55522,-1.97,0.0108,16382,0.685,"MAN2C1, MANBA, MAN2B2, NEU1, MAN2B1, NEU3",1.96657624451305,0.164309428507574,FALSE
+"A549","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.26587,-0.953,0.459,15105,0.72,"ATP6V1B1, ATP5PB, LHPP, NDUFA2, NDUFV3, UQCRB, NDUFA5, ATP6AP1, SDHD, COX8A, COX7C, UQCR10, ATP5PO, ATP6V1G2, NDUFA11, NDUFA3, NDUFA6, ATP5MG, NDUFS6, ATP5ME, NDUFC1, ATP6V0B, UQCRHL, ATP6V0C, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, NDUFS7, NDUFV1, COX5B",0.338187314462739,0.142667503568732,FALSE
+"A549","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.4791,1.78,0.0132,3741,0.194,"GCNT3, GALNT13, GALNT10, GALNT14, GALNT1, GALNT18, GALNT4, C1GALT1C1, GALNT16, GALNT2, GALNT7, C1GALT1",1.87942606879415,0.712198270069774,TRUE
+"A549","Input","KEGG_P53_SIGNALING_PATHWAY",0.25453,0.933,0.533,3564,0.705,"TP53I3, CCND3, SERPINE1, DDB2, RRM2B, TNFRSF10B, CASP8, CCNE1, CCNB1, CCNB3, APAF1, SFN, CDKN1A, CCNB2, FAS, CYCS, CDK1, IGFBP3, GADD45B, STEAP3",0.273272790973428,0.151810883008601,FALSE
+"A549","Input","KEGG_PANCREATIC_CANCER",-0.27333,-0.975,0.458,16063,0.699,"ARHGEF6, PIK3R1, E2F2, RALA, TGFB3, BRAF, PIK3CA, AKT1, PIK3R3, MAPK3, CDKN2A, VEGFA, RAC2, RALGDS, VEGFB, PIK3R2",0.339134521996131,0.155522824254319,FALSE
+"A549","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.17439,-0.618,0.977,11352,0.972,"VNN1, DPYS, ENPP3, UPB1, VNN2, PPCS, PANK4",0.0101054362812269,0.0123337350737254,FALSE
+"A549","Input","KEGG_PARKINSONS_DISEASE",-0.23122,-0.843,0.667,15433,0.823,"NDUFA2, NDUFV3, UQCRB, NDUFA5, SDHD, COX8A, COX7C, PRKN, UQCR10, SNCA, ATP5PO, NDUFA3, NDUFA6, UBE2J2, UBE2L6, UBE2G2, NDUFS6, NDUFC1, UQCRHL, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, UBA7, NDUFS7, NDUFV1, COX5B",0.175874166083451,0.0846001647877302,FALSE
+"A549","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.38862,1.4,0.0907,2529,0.38,"YWHAQ, ROCK2, TUBA4A, ARPC3, NCL, ITGB1, KRT18, ACTG1, TUBAL3, RHOA, PRKCA, EZR, CLDN1, ARPC4, TUBA1C, TUBA1B, ACTB",1.0423927129399,0.42021640338319,FALSE
+"A549","Input","KEGG_PATHWAYS_IN_CANCER",-0.21416,-0.756,0.789,15302,0.888,"LAMA4, IL6, AXIN2, PIAS4, CCNA1, FGFR3, RXRA, FZD7, AXIN1, DVL2, ARNT, RBX1, PDGFRB, CBLC, FGF22, WNT10A, CBL, PIK3R1, LAMA1, SKP2, RASSF5, DVL1, EP300, HDAC1, MMP1, FGF12, PTCH1, WNT2B, PAX8, TRAF4, E2F2, SUFU, STK36, BMP2, FGF13, BCL2, RALA, ELOB, TGFB3, FGFR2, BRAF, LEF1, PIK3CA, RASSF1, AKT1, CCNE2, WNT5A, FGF11, FZD4, CDKN1B, CRKL, CREBBP, CDKN2B, PIAS3, RUNX1, PLCG1, PIK3R3, FZD1, MAPK3, CDKN2A, GLI3, MTOR, FLT3LG, VEGFA, RAC2, RALGDS, MAX, MECOM, CTBP1, VEGFB, FOS, BCR, PPARD, DVL3, PML, RXRB, PIK3R2",0.10292299679058,0.051587034221399,FALSE
+"A549","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.53474,1.91,0.0136,1276,0.132,"UGDH, AKR1B1, RPE, RPEL1, UGP2",1.86646109162978,0.87942606879415,TRUE
+"A549","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.45145,1.65,0.0349,1965,0.246,"PGD, G6PD, TKT, GPI, RPE, RPEL1, RBKS, PFKP, PRPS1, TALDO1",1.45717457304082,0.609064892896621,TRUE
+"A549","Input","KEGG_PEROXISOME",-0.27864,-0.997,0.413,15908,0.736,"PAOX, PMVK, PEX3, PEX6, PEX11G, PEX1, PXMP2, PEX11B, PEX19, PEX10, PRDX5, ACSL5, IDH2, FAR2, PEX16, PEX26, ABCD4, PEX7, ACOT8, ABCD1, HMGCL, PEX14",0.384049948343599,0.133122185662501,FALSE
+"A549","Input","KEGG_PHENYLALANINE_METABOLISM",0.3522,1.26,0.193,1539,0.446,"ALDH3A1, GOT2, ALDH3B1",0.714442690992226,0.350665141287858,FALSE
+"A549","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.3203,-1.15,0.243,15324,0.751,"PLCB2, PLCB1, INPP5J, CALML6, CDS1, PIK3R1, ITPR3, PLCB3, ITPKB, PIK3CA, INPP5B, ITPKA, PI4KB, DGKZ, DGKQ, SYNJ1, PLCG1, INPPL1, PIK3R3, INPP5E, PI4KA, PIP5K1C, PIK3R2",0.614393726401688,0.124360062995832,FALSE
+"A549","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.33456,1.22,0.187,2727,0.478,"HMOX1, EARS2, COX15, COX10, BLVRB, HCCS, FECH, FTH1, ALAS1",0.728158393463501,0.320572103387881,FALSE
+"A549","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.22384,-0.798,0.753,17311,0.856,"ACSL5, SORBS1, PLTP, SLC27A1, PPARA, PPARD, CPT2, RXRB",0.123205023799299,0.0675262353228468,FALSE
+"A549","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45993,1.65,0.0432,3031,0.246,"BAAT, AKR1C4, HSD3B7, SLC27A5, ACOX2",1.36451625318509,0.609064892896621,TRUE
+"A549","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.33263,-1.18,0.217,12250,0.763,"CD3D, CD19, IL2RG, IGLL1, LCK, RAG1, BLNK, JAK3, DCLRE1C, CIITA, TAP2, IL7R, TNFRSF13C, RFXAP, RFXANK",0.66354026615147,0.11747546204512,FALSE
+"A549","Input","KEGG_PRION_DISEASES",-0.29271,-1.07,0.352,15251,0.646,"CCL5, IL6, IL1B, NCAM2, ELK1, NCAM1, NOTCH1, PRKACA, MAPK3, FYN, EGR1",0.453457336521869,0.189767482004916,FALSE
+"A549","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21174,-0.77,0.804,15123,0.886,"MAPK10, RPS6KA1, CCNA1, ANAPC2, MAPK12, PKMYT1, PIK3R1, MAPK14, BRAF, PIK3CA, AKT1, PRKACA, FZR1, PIK3R3, MAD2L2, MAPK3, MAPK13, RPS6KA2, GNAI2, PIK3R2",0.0947439512515487,0.0525662781129492,FALSE
+"A549","Input","KEGG_PROPANOATE_METABOLISM",0.35508,1.29,0.155,3700,0.457,"ALDH3A2, ALDH1B1, LDHA, LDHB, SUCLG1, HADHA, ACACA, HIBCH, ALDH2, ACACB, ECHS1, SUCLA2, ACAT1",0.809668301829709,0.34008379993015,FALSE
+"A549","Input","KEGG_PROSTATE_CANCER",-0.2988,-1.09,0.309,15622,0.67,"CREB3L1, PDGFRB, PDGFC, PIK3R1, CREB3L2, EP300, E2F2, BCL2, FGFR2, BRAF, LEF1, PIK3CA, AKT1, CCNE2, CDKN1B, CREBBP, ATF4, CREB3L4, PIK3R3, MAPK3, MTOR, CREB5, PIK3R2",0.510041520575165,0.173925197299174,FALSE
+"A549","Input","KEGG_PROTEASOME",0.49313,1.8,0.0226,3432,0.195,"PSMA4, PSMC4, PSMB6, PSMD12, PSME3, PSMD8, PSMD1, PSMD11, PSMD14, PSME4, PSMC5, PSMA1, PSMB5, PSMA6, POMP, PSMC6, PSMC1, PSMA3, PSMA2, PSMF1, PSMB3",1.6458915608526,0.709965388637482,TRUE
+"A549","Input","KEGG_PROTEIN_EXPORT",0.29925,1.1,0.269,3377,0.552,"SEC11A, OXA1L, SRP68, SEC61A2, SEC62, SEC11C, SRP72",0.570247719997592,0.258060922270801,FALSE
+"A549","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.31653,1.14,0.27,3303,0.516,"FXYD2, GLS, ATP1B1, GLUD2, MDH1, GLUD1, ATP1B3",0.568636235841013,0.287350298372789,FALSE
+"A549","Input","KEGG_PURINE_METABOLISM",0.36439,1.32,0.129,2835,0.43,"PDE11A, PDE4D, PDE3A, ATIC, PDE10A, PDE8A, NME1, PDE7B, PDE4B, POLR2I, PRIM1, DGUOK, NT5C2, ADA, PDE1A, POLR1E, PDE1C, PRPS1, RRM2B, NME2, PAPSS2, POLE4, POLR2C, GMPS, POLE2, PNP, PKM, NME4, PFAS, HPRT1, POLA1, PNPT1, POLR3K, POLR3G, POLR3F, ADPRM, POLD4, RRM1, PDE6G, PAICS",0.889410289700751,0.366531544420413,FALSE
+"A549","Input","KEGG_PYRIMIDINE_METABOLISM",0.38387,1.39,0.101,4771,0.381,"CTPS1, TXNRD1, NME1, UMPS, POLR2I, PRIM1, NT5C2, CDA, POLR1E, RRM2B, NME2, POLE4, POLR2C, UCK2, POLE2, PNP, NME4, POLA1, PNPT1, POLR3K, POLR3G, DTYMK, POLR3F, POLD4, RRM1, CMPK1, POLR3D, NT5C, POLR1B, AK3, POLR2D, UPRT, POLE3, DHODH, TK1, NME7, POLR2L, ITPA, NT5C3A, POLR3H, POLR3C, POLR3B, CTPS2, POLR1D, POLR1A, TXNRD2",0.995678626217357,0.419075024324381,FALSE
+"A549","Input","KEGG_PYRUVATE_METABOLISM",0.44128,1.62,0.05,2894,0.259,"AKR1B1, ME1, ALDH3A2, ALDH1B1, LDHA, DLD, LDHB, PC, ME2, MDH1, PKM, ACACA, ALDH2, ME3",1.30102999566398,0.586700235918748,FALSE
+"A549","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.19725,0.718,0.889,4136,0.903,"PDGFD, ROCK2, ITGAV, ITGAM, ARPC3, ITGAE, F2, CRK, ITGB1, FGF2, PPP1CC, GNA13, VAV1, ITGA11, NCKAP1, TMSB4Y, ACTG1, ACTN4, CFL2, ITGB5, VCL, RHOA, CFL1, TMSB4X, HRAS, CYFIP2, EZR, FGFR1, FGFR4, ARPC4, ACTB, RDX, ENAH, PFN1, GNG12, PPP1R12A, RRAS, SSH2, MSN, EGFR, CYFIP1, PPP1CB, SOS1, PTK2, RRAS2, MAP2K1, F2R, ACTN1, VAV3, BRK1, APC, PXN, ITGB6, BDKRB2, DOCK1, ITGA2B, KRAS, PFN4, SOS2, FN1",0.0510982390297863,0.0443122496864942,FALSE
+"A549","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.33093,1.2,0.221,3285,0.48,"IFNA13, ULK1, ULK2, PRKAA2, ATG7, ATG4C",0.655607726314889,0.318758762624413,FALSE
+"A549","Input","KEGG_RENAL_CELL_CARCINOMA",-0.30778,-1.1,0.293,15797,0.665,"ARNT, RBX1, PIK3R1, RAP1A, EP300, ELOB, TGFB3, BRAF, PIK3CA, AKT1, GAB1, CRKL, CREBBP, PAK6, PAK2, PIK3R3, MAPK3, VEGFA, VEGFB, PIK3R2",0.533132379645891,0.177178354696895,FALSE
+"A549","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.23516,0.874,0.611,1808,0.717,"NLN, AGTR1",0.213958789757446,0.1444808443322,FALSE
+"A549","Input","KEGG_RETINOL_METABOLISM",0.29618,1.1,0.296,3817,0.552,"ALDH1A1, CYP26A1, BCO1, CYP26B1, DHRS3, DHRS4, CYP2C9, DHRS4L2, RDH11, RDH5, PNPLA4",0.528708288941061,0.258060922270801,FALSE
+"A549","Input","KEGG_RIBOFLAVIN_METABOLISM",0.43987,1.61,0.0401,409,0.242,"RFK, ACP1",1.39685562737982,0.616184634019569,TRUE
+"A549","Input","KEGG_RIBOSOME",-0.31709,-1.11,0.282,16409,0.681,"RPS23, RPL9, RPL38, RPS21, RPL28, RPS25, RPS8, RPL18A, RPS15, RPS10, RPL3, RPL22, RPS18, RPL13, RPS28, RPS12, RPL35A, RPL37, RPL36, FAU",0.549750891680639,0.166852888087215,FALSE
+"A549","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.2012,0.735,0.853,2264,0.894,"IFNA13, TBK1, DDX3Y, TRAF2, DDX3X, CHUK, IFNE, NFKBIB, CASP8",0.069050968832477,0.0486624812040823,FALSE
+"A549","Input","KEGG_RNA_DEGRADATION",0.27831,1.01,0.396,3655,0.606,"PARN, ENO3, HSPD1, XRN2, EXOSC5, PAPOLA, HSPA9, WDR61, LSM5, PNPT1, CNOT7, C1D, PAPOLG, EXOSC1, ENO1, MPHOSPH6, CNOT9, CNOT1, LSM1, EXOSC3",0.402304814074488,0.217527375833714,FALSE
+"A549","Input","KEGG_RNA_POLYMERASE",0.32365,1.18,0.209,4747,0.494,"POLR2I, POLR1E, POLR2C, POLR3K, POLR3G, POLR3F, POLR3D, POLR1B, POLR2D, POLR2L, POLR3H, POLR3C, POLR3B, POLR1D, POLR1A",0.679853713888946,0.306273051076353,FALSE
+"A549","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.25081,0.927,0.531,4652,0.682,"GGT1, METTL6, PAPSS2, METTL2B, MAT2A, BUD23, SEPHS1, AHCYL1, AHCY, MARS2, MAT2B",0.274905478918531,0.166215625343521,FALSE
+"A549","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.23175,0.85,0.613,3074,0.749,"RARB, COL4A4, ITGAV, TRAF2, ITGB1, COL4A6, AKT2, BIRC3, CHUK, CKS1B, COL4A1, CCNE1, AKT3, APAF1, PTGS2, TRAF3, PIAS1, COL4A2, BCL2L1, CYCS, LAMC2",0.212539525481585,0.125518182300534,FALSE
+"A549","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.45204,-1.66,0.0388,16460,0.556,"VAMP4, STX10, STX16, STX12, SEC22B, STX5, VAMP5, TSNARE1, VAMP2, STX3, SNAP29, USE1, SNAP23",1.41116827440579,0.254925208417942,FALSE
+"A549","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33046,1.21,0.187,3275,0.474,"GLA, GAL3ST1, SGMS1, DEGS1, ASAH2, GALC, PLPP1, ACER3, SPTLC2, SGPP1, SPTLC1, PLPP2",0.728158393463501,0.324221658325915,FALSE
+"A549","Input","KEGG_SPLICEOSOME",-0.30687,-1.12,0.27,17451,0.7,"DHX16, PRPF6, SNU13, TRA2B, LSM4, PRPF38B, SRSF4, CCDC12, PPIH, SYF2, SF3A1, HNRNPA1L2, SNRPD1, LSM7, MAGOH, SNRPD3, LSM6, CWC15, SRSF5, NCBP2, DDX39B, CHERP, XAB2, PRPF38A, SF3A2",0.568636235841013,0.154901959985743,FALSE
+"A549","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.25014,0.911,0.54,1700,0.69,"UGDH, PGM2L1, GPI, UGP2, MGAM",0.267606240177031,0.161150909262745,FALSE
+"A549","Input","KEGG_STEROID_BIOSYNTHESIS",-0.44337,-1.62,0.0409,15767,0.541,"CEL, SC5D, CYP27B1, TM7SF2, DHCR24, LSS",1.38827669199266,0.266802734893431,FALSE
+"A549","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.42547,1.55,0.0601,1711,0.279,"AKR1C2, AKR1C3, SULT2B1, AKR1C1, SRD5A2, HSD17B6, AKR1C4",1.22112552799726,0.554395796726402,FALSE
+"A549","Input","KEGG_SULFUR_METABOLISM",0.36038,1.28,0.166,2967,0.435,"SULT2B1, CHST11, PAPSS2, SULT1A4",0.779891911959945,0.361510743045363,FALSE
+"A549","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.43534,1.58,0.0342,1426,0.26,"GRIN2B, C5, SNRPB, SSB, C1S, ACTN4",1.46597389394386,0.585026652029182,FALSE
+"A549","Input","KEGG_TASTE_TRANSDUCTION",0.24979,0.899,0.55,1430,0.698,"TAS2R50, TAS2R9, PDE1A, ASIC2, TAS2R14, PRKX",0.259637310505756,0.156144577376839,FALSE
+"A549","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.53176,1.95,0.00875,374,0.124,"BAAT, GGT1",2.05799194697769,0.906578314837765,TRUE
+"A549","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.32003,-1.15,0.242,15900,0.751,"DHDDS, PMVK, FDPS, MVD",0.616184634019569,0.124360062995832,FALSE
+"A549","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28987,1.06,0.316,3397,0.552,"BMPR1B, ROCK2, TGFBR1, TGFB2, BMPR1A, BMP6, PPP2CB, INHBB, SMAD3, RHOA, CUL1, SMAD2, RBL1, SMAD6, LTBP1, SMAD7, RPS6KB1, AMHR2, ZFYVE16, BMPR2, SKP1, TGFBR2, ID3, SMAD4, ID2",0.500312917381596,0.258060922270801,FALSE
+"A549","Input","KEGG_THYROID_CANCER",-0.30502,-1.11,0.291,16623,0.681,"PAX8, BRAF, LEF1, MAPK3, RXRB",0.536107011014093,0.166852888087215,FALSE
+"A549","Input","KEGG_TIGHT_JUNCTION",0.20647,0.741,0.83,2568,0.892,"PRKCQ, PARD3, PPP2R2C, SRC, TJP1, AKT2, PPP2CB, ACTG1, ACTN4, PPP2R2A, MAP3K20, RAB3B, RHOA, PRKCA, HRAS, CSNK2A1, MPDZ, CLDN1, CLDN2, AKT3, ACTB, CLDN23",0.0809219076239261,0.0496351456238769,FALSE
+"A549","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23446,-0.837,0.674,15123,0.81,"MAPK10, JUN, CCL5, IL6, IL1B, TLR5, MAPK12, TLR4, PIK3R1, TLR2, MAPK14, TIRAP, LY96, PIK3CA, AKT1, TLR3, TOLLIP, IFNAR1, PIK3R3, MAPK3, IRF7, MAPK13, TICAM1, TAB1, FOS, MAP2K7, PIK3R2",0.17134010346468,0.0915149811213502,FALSE
+"A549","Input","KEGG_TRYPTOPHAN_METABOLISM",0.25942,0.955,0.463,3700,0.685,"KYNU, ALDH3A2, ALDH1B1, IDO2, HADHA, ALDH2, AFMID, AADAT, TDO2, AOX1, ECHS1, ACAT1",0.334419008982047,0.164309428507574,FALSE
+"A549","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.3654,-1.31,0.135,12793,0.839,"MAFA, CACNA1B, PDX1, IKBKB, CACNA1A, GCK, TNF, SLC2A4, HK1, CACNA1C, MAPK10, PRKCD, KCNJ11, PIK3R1, INSR, PIK3CA, SOCS1, PIK3R3, MAPK3, MTOR, PIK3R2, HK2",0.869666231504994,0.0762380391712997,FALSE
+"A549","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.2424,-0.858,0.616,11839,0.816,"PTPRN2, IL12A, CD86, GZMB, TNF, IL1A, IL1B, CPE, ICA1, GAD1",0.210419287835575,0.0883098412461389,FALSE
+"A549","Input","KEGG_TYROSINE_METABOLISM",0.27577,1.04,0.368,1856,0.564,"HGD, ALDH3A1, GOT2, ALDH3B1, METTL6, METTL2B",0.434152181326482,0.248720896016658,FALSE
+"A549","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.21793,-0.784,0.789,15885,0.873,"CBLC, MAPK12, CBL, PIK3R1, BCL10, MAPK14, PIK3CA, AKT1, NCK2, PAK6, LAT, PAK2, PLCG1, PIK3R3, MAPK3, NFATC4, DLG1, MAPK13, FYN, FOS, MAP2K7, PIK3R2",0.10292299679058,0.0589857562944303,FALSE
+"A549","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.26016,0.927,0.491,3348,0.682,"NEDD4, UBA2, CUL3, UBE2G1, HERC4, UBE2A, BIRC6, CDC27, UBE2Q2, UBE2S, DDB2, BIRC3, MID1, BRCA1, ANAPC5, ERCC8, WWP1, CUL1, FANCL, UBE2D1, SAE1, TRIM32, UBE2E1, CUL2, KLHL9, UBE2N, SKP1, CDC23, PIAS1, UBE2D2, CDC26, TRIM37, UBE2M, ANAPC7, ANAPC1, FBXW11, ELOC",0.308918507877032,0.166215625343521,FALSE
+"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.33611,-1.2,0.2,18726,0.818,"VARS2",0.698970004336019,0.087246696328677,FALSE
+"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.38891,-1.38,0.105,18177,0.839,"PCCB, BCKDHB, ACAD8, HADH, MCCC1, ALDH6A1, IVD, OXCT1, HMGCL",0.978810700930062,0.0762380391712997,FALSE
+"A549","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.19282,0.703,0.878,2257,0.907,"PPP1R14A, PRKCQ, ROCK2, CALM2, PPP1CC, ADRA1B, GNA13, PLA2G4A, PLCB4, PRKX, RHOA, AGTR1, PRKCA, CALD1",0.0565054840938974,0.0423927129399047,FALSE
+"A549","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.27591,-0.995,0.412,15622,0.724,"CREB3L1, GNAS, CREB3L2, ARHGDIB, RAB5B, DYNC1I1, PRKACA, CREB3L4, RAB11B, VAMP2, CREB5, DYNLL2",0.385102783966865,0.140261433802853,FALSE
+"A549","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.33062,-1.18,0.212,15995,0.763,"MAPK12, MAPKAPK2, PIK3R1, SHC2, MAPK14, PIK3CA, AKT1, PLA2G12A, MAPKAPK3, PLCG1, PIK3R3, PLA2G6, MAPK3, NFATC4, PLA2G4B, VEGFA, RAC2, MAPK13, PIK3R2",0.673664139071249,0.11747546204512,FALSE
+"A549","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.21946,0.783,0.773,2529,0.869,"ATP6V1E2, TJP1, KDELR1, ACTG1, PRKX, ATP6V0E1, PRKCA, SLC12A2, SEC61A2, ACTB",0.111820506081675,0.0609802235513335,FALSE
+"A549","Input","KEGG_VIRAL_MYOCARDITIS",0.20678,0.752,0.794,2529,0.9,"SGCD, EIF4G2, ACTG1, SGCA, CAV1, CASP8, ACTB",0.100179497572904,0.0457574905606751,FALSE
+"A549","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24656,-0.891,0.593,14908,0.781,"RAC3, CAMK2B, MAPK10, NFATC1, CCND2, JUN, PLCB2, PLCB1, DAAM2, AXIN2, CHD8, LRP5, FZD7, AXIN1, DVL2, RBX1, WNT10A, PPP2R5D, DVL1, EP300, PLCB3, SENP2, WNT2B, LEF1, WNT5A, FZD4, PRKACA, PRICKLE1, CREBBP, FRAT2, PORCN, PPP2R5B, FZD1, FRAT1, NFATC4, RAC2, CSNK2B, CTBP1, TBL1XR1, CSNK1E, PPARD, CTNNBIP1, DVL3",0.226945306635737,0.1073489661227,FALSE
+"H1703","Input","KEGG_ABC_TRANSPORTERS",-0.3575,-1.33,0.119,14274,0.534,"ABCB11, ABCC2, ABCA8, ABCC9, ABCA6, CFTR, ABCA4, ABCB4, ABCB9, ABCA13, ABCA12, ABCD3, ABCB1, ABCA10, ABCA1, ABCC1, ABCG2, ABCC6, ABCG1, ABCD4, ABCC3, ABCA5, ABCB6",0.924453038607469,0.272458742971444,FALSE
+"H1703","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.38364,1.25,0.162,3007,0.599,"EIF4EBP1, STAT3, GRB2, FLT3, MTOR, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, RPS6KB1",0.790484985457369,0.222573177610689,FALSE
+"H1703","Input","KEGG_ADHERENS_JUNCTION",0.29159,0.93,0.523,3288,0.739,"RAC1, SMAD2, VCL, FGFR1, WASF1, MAP3K7, TGFBR2, EP300, MAPK1, CSNK2B, CTNNA1, SMAD4, AFDN, YES1, IQGAP1, WASF2, NLK, SSX2IP, NECTIN2, RHOA",0.281498311132726,0.131355561605174,FALSE
+"H1703","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.39435,1.27,0.148,3697,0.625,"STAT3, ADIPOR2, MAPK9, SOCS3, PRKAG2, PRKAA1, NFKBIE, STK11, MAPK8, MTOR, PTPN11, TNFRSF1A, CHUK, NFKB1, IKBKG, AKT1, PCK2, LEPR, CPT1A, CAMKK2, AKT3, NFKBIB",0.829738284605043,0.204119982655925,FALSE
+"H1703","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.25462,0.834,0.704,3341,0.819,"ADSL, CAD, ASNS, GOT1, NIT2, GLUD1, ASL",0.152427340857888,0.0867160982395816,FALSE
+"H1703","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.17903,0.578,0.985,3422,1,"SGK1, NEDD4L, MAPK1, KRAS, ATP1A3, PRKCA",0.00656376950238827,0,FALSE
+"H1703","Input","KEGG_ALLOGRAFT_REJECTION",0.24222,0.768,0.798,14486,0.89,"CD40, IL12B, IL5, IL12A, IFNG, CD28, CD40LG, IL2, FASLG, CD80, IL4, IL10, PRF1, TNF, FAS, CD86, GZMB",0.0979971086492706,0.0506099933550872,FALSE
+"H1703","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.47522,-1.75,0.0196,12060,0.408,"PLA2G2A, PLA2G5, PLA2G2C, PLA2G2F, PLA2G4B, PLA2G4E, PLA2G6, PLA2G3, ACOX1, PLA2G10, FADS2, PLA2G4A",1.70774392864352,0.38933983691012,FALSE
+"H1703","Input","KEGG_ALZHEIMERS_DISEASE",0.27885,0.902,0.581,4485,0.774,"GRIN2B, NDUFS6, ITPR2, SDHA, APH1A, NDUFA9, ATP2A1, GAPDH, NDUFA1, ATP5F1A, COX7A2L, IDE, TNFRSF1A, PLCB3, CALML6, PLCB4, MAPK1, NDUFS4, NDUFA3, PPP3R2, CYCS, BID, CYC1, PPP3CB, ATP5F1D, SDHB, NAE1, NDUFS3, ADAM17, CALM3, NDUFA6, NDUFA10, NDUFB8, ATP2A3, ATP5F1C, UQCRHL, UQCRFS1, NDUFC1, PSEN2, BAD, LRP1",0.235823867609669,0.111259039317107,FALSE
+"H1703","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.48167,1.56,0.0459,3842,0.434,"YARS2, RARS2, IARS2, HARS2, TARS2, FARSA, AARS2, FARS2",1.33818731446274,0.362510270487489,FALSE
+"H1703","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.23372,-0.84,0.629,16354,0.773,"GCK, NPL, GFPT2, RENBP, GFPT1, MPI, GALE, UGDH, HK2, NAGK",0.201349354554731,0.111820506081675,FALSE
+"H1703","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.34517,1.1,0.323,2986,0.599,"GRIN2B, MAPK11, NEFH, MAPK12, RAC1, DAXX, TNFRSF1A, PPP3R2, CYCS, BID, PPP3CB, MAPK14",0.490797477668897,0.222573177610689,FALSE
+"H1703","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.45574,1.47,0.0709,3014,0.417,"NFYB, HSPA4, KLRC2, KLRC4, HSPA1L, HSP90AB1, TAP2, RFX5, KLRC3, TAP1, PSME3, NFYC, HSPA1A, TAPBP, RFXANK",1.14935376481693,0.379863945026242,FALSE
+"H1703","Input","KEGG_APOPTOSIS",0.34432,1.11,0.285,5095,0.616,"MAP3K14, AIFM1, BIRC3, PRKAR2A, BIRC2, TNFRSF1A, DFFA, CHUK, PRKAR2B, NFKB1, IKBKG, AKT1, XIAP, PPP3R2, CYCS, RIPK1, IRAK1, BID, PPP3CB, PRKACA, AKT3, BAX, MYD88, TRAF2, NFKBIA, BAD, ATM, PIK3CB, IRAK2, PRKAR1B, IKBKB, EXOG, TRADD",0.54515513999149,0.210419287835575,FALSE
+"H1703","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.44904,-1.6,0.0529,15113,0.41,"PTGIS, GGT6, CYP2J2, GGT5, PLA2G10, CYP4F3, ALOX5, PTGS1, GPX2, PTGS2, LTC4S, GPX3, GPX7, AKR1C3, PLA2G4A, TBXAS1, PTGES, EPHX2, GGT7, CBR3, GPX1",1.27654432796481,0.387216143280265,FALSE
+"H1703","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.33675,-1.2,0.188,17949,0.554,"AGMAT, CPS1, CKMT1A, MAOA, CKMT1B, NAGS, ALDH2, ARG2, ASS1, SAT2",0.72584215073632,0.25649023527157,FALSE
+"H1703","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.31601,-1.18,0.216,16215,0.572,"DSC2, CACNA1C, ITGA11, TCF7L2, CACNA2D3, CACNG6, RYR2, SLC8A1, CACNA1D, ITGB3, LEF1, ITGA7, ITGB6, DSG2, ITGA1, GJA1, ITGB4, ACTN4, ITGB8, ITGA2",0.665546248849069,0.242603971206976,FALSE
+"H1703","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.23666,-0.909,0.617,18008,0.695,"UGDH, ALDH2",0.209714835966758,0.158015195409886,FALSE
+"H1703","Input","KEGG_ASTHMA",0.2476,0.815,0.725,14383,0.831,"CD40, IL13, IL5, IL9, MS4A2, EPX, FCER1A, FCER1G, CD40LG, IL3, CCL11, IL4, IL10, TNF, PRG2, RNASE3",0.139661993429006,0.080398976215889,FALSE
+"H1703","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.28368,-1.01,0.414,9594,0.633,"IFNA4, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD28, CD40LG, IL2, TPO, FASLG, TSHB, CD80, IFNA13, IL4, CTLA4, IL10, IFNA21, TG, PRF1, TSHR, CGA, FAS, IFNA5, CD86, GZMB",0.382999658879101,0.198596289982645,FALSE
+"H1703","Input","KEGG_AXON_GUIDANCE",-0.25682,-0.937,0.531,15670,0.681,"EPHA7, CXCL12, SEMA3G, ABLIM1, EPHB6, ROBO2, EPHA1, EPHA3, PLXNC1, EPHA5, PAK3, EPHA6, FES, SEMA6D, NTNG1, FYN, PLXNB1, SEMA4F, SEMA4A, ABLIM2, RND1, NFATC2, SLIT2, SEMA5A, SEMA7A, EPHB2, EFNB3, PAK6, HRAS, EPHA4, EPHB3, PLXNA2, SEMA3B, RAC2, NFATC4, NRP1, PLXNB3, ABLIM3, NTN4, EFNB2, PLXNA3, RGS3",0.274905478918531,0.166852888087215,FALSE
+"H1703","Input","KEGG_BASAL_CELL_CARCINOMA",-0.225,-0.834,0.659,15333,0.772,"HHIP, PTCH1, WNT7B, TP53, WNT7A, SHH, WNT10A, TCF7L2, WNT11, WNT3, LEF1, FZD9, FZD4, FZD8, BMP2, WNT5A, FZD7, BMP4, GLI3, FZD3",0.18111458540599,0.112382699664264,FALSE
+"H1703","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.48489,1.54,0.0523,3630,0.441,"TAF9, TBP, GTF2H2, TAF9B, TAF1, TAF5, TAF4B, TAF6, TAF7, TAF2, TAF11, TBPL1, GTF2A1L, TAF5L, TAF1L, GTF2A2",1.28149831113273,0.355561410532161,FALSE
+"H1703","Input","KEGG_BASE_EXCISION_REPAIR",0.51093,1.66,0.0228,7134,0.393,"OGG1, POLD2, POLD1, UNG, PARP1, NEIL2, POLL, POLE, LIG1, POLE2, MPG, MBD4, LIG3, NEIL3, NTHL1, PARP4, POLD3, TDG, NEIL1, POLE3, MUTYH, APEX2, FEN1, PARP3, HMGB1, POLB",1.64206515299955,0.405607449624573,FALSE
+"H1703","Input","KEGG_BETA_ALANINE_METABOLISM",0.46985,1.51,0.0483,3228,0.412,"AOC2, AOC3, SMS, ALDH3A2, DPYS, HADHA, SRM, ALDH9A1",1.31605286924849,0.385102783966865,FALSE
+"H1703","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.2599,-0.946,0.464,16509,0.692,"PECR, FADS2, HSD17B12, ACOT4, TECR, ELOVL6",0.333482019445119,0.159893905543242,FALSE
+"H1703","Input","KEGG_BLADDER_CANCER",0.28469,0.934,0.519,2591,0.764,"VEGFD, E2F2, MAPK1, E2F3, E2F1, CDKN2A, KRAS, RAF1, NRAS, MAP2K2",0.284832642151542,0.11690664142431,FALSE
+"H1703","Input","KEGG_BUTANOATE_METABOLISM",-0.3172,-1.15,0.247,17676,0.568,"ABAT, ACSM3, ALDH2, BDH2, BDH1, ACADS",0.607303046740334,0.245651664288981,FALSE
+"H1703","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.36606,1.18,0.209,2705,0.565,"LILRB3, MALT1, NFATC1, RAC1, NFKBIE, GRB2, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, PPP3CB",0.679853713888946,0.247951552180562,FALSE
+"H1703","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.25934,0.842,0.682,2936,0.812,"PDGFRA, TBXA2R, CACNA1A, GNAL, ITPR2, ATP2A1, PHKA1, CACNA1G, ADORA2A, VDAC2, HRH1, PPID, PLCE1, TRHR, PLCB3, CALML6, PLCB4, ADCY3, CACNA1H, VDAC1, SLC25A5, PPP3R2, CACNA1B, PPP3CB, PLCD4, PRKACA, PHKA2",0.166215625343521,0.0904439707588247,FALSE
+"H1703","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.17124,0.549,0.985,6539,1,"CACNB1, SLC9A6, COX7A2L, TPM2, TPM3, CYC1, ATP1A3, CACNB4, CACNA2D1, UQCRHL, UQCRFS1, TNNC1, COX7C, UQCRC1, TPM1, UQCR11, COX6C, UQCRB, ATP1B3, UQCRC2, CACNB3, CACNG4, UQCR10, COX7B",0.00656376950238827,0,FALSE
+"H1703","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.27553,-1.04,0.365,14211,0.677,"ITGAL, CD86, PECAM1, CDH15, ITGB2, CLDN10, CLDN2, CADM3, NRXN2, CLDN9, CLDN14, CD34, CLDN16, CDH5, NCAM2, VCAM1, SELL, JAM2, NLGN4X, CD6, CNTNAP2, MPZ, CD22, CLDN22, CD4, PDCD1LG2, CNTN1, NLGN1, CLDN11, SDC2, NRXN3, ICAM2, GLG1, NCAM1, CDH1, CLDN3, VCAN, CDH3, NRCAM, CD274, CLDN23, CADM1, NECTIN3, CLDN7, CLDN4, ICAM3, ITGB8, ICAM1, F11R",0.437707135543525,0.169411331314856,FALSE
+"H1703","Input","KEGG_CELL_CYCLE",0.47154,1.52,0.0522,6373,0.419,"CCNB3, CCND2, SMAD2, MCM5, CHEK2, MAD2L2, ORC3, YWHAH, E2F2, MCM3, ESPL1, EP300, E2F3, ORC5, E2F1, CDKN2A, CDC25B, CDC45, HDAC2, YWHAE, CDC25A, SMAD4, CDC20, CCNB1, PRKDC, E2F5, SMC1B, CDC27, TTK, PTTG2, ANAPC1, ANAPC7, CCNA2, ANAPC4, CHEK1, FZR1, PKMYT1, RAD21, STAG2, CDC23, CDC6, MCM2, YWHAQ, RB1, TGFB1, PLK1, BUB1B, BUB1, ATM, CREBBP, CCNE2, SMC3, SMAD3, SMC1A, GADD45B, STAG1, CDKN1B, MAD2L1, CDK2, CCND3, TFDP1, MAD1L1, RBX1, YWHAG, MCM6, TFDP2, ATR, E2F4, CDC16, ABL1, MCM7, CDC7, CDK7, CDK1, ORC1, YWHAB, CDKN2C, YWHAZ, CDKN2B, PTTG1",1.28232949699774,0.377785977033705,FALSE
+"H1703","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.26517,0.861,0.639,2894,0.821,"RAC1, CCR10, STAT3, SHC1, GRK3, ROCK1, GRK6, GNG13, GRB2, CCL28, CRKL, CCL2, PLCB3, XCL1, CHUK, PLCB4, ADCY3, CSK, MAPK1, CRK, NFKB1, IKBKG, AKT1, KRAS, SOS1, RAF1, CCL5, NRAS, GNB5, GNB2, ARRB2, GNB4, PRKACA",0.1944991418416,0.0856568428805592,FALSE
+"H1703","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.37914,1.22,0.19,2591,0.576,"SHC1, GRB2, E2F2, CRKL, CBL, PTPN11, TGFBR2, CHUK, MAPK1, CRK, E2F3, NFKB1, E2F1, IKBKG, CDKN2A, AKT1, KRAS, HDAC2, SOS1, RAF1, CTBP1, NRAS, SMAD4, MAP2K2",0.721246399047171,0.239577516576788,FALSE
+"H1703","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.36992,1.2,0.199,3869,0.556,"CLOCK, CRY1, PER3, CSNK1D, PER1, CSNK1E",0.701146923590293,0.254925208417942,FALSE
+"H1703","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.33418,1.08,0.311,4539,0.625,"PDHA1, SDHA, ACO2, PCK2, SDHB, OGDH, ACLY, IDH3B, IDH3G, SUCLA2, IDH3A",0.507239610973163,0.204119982655925,FALSE
+"H1703","Input","KEGG_COLORECTAL_CANCER",0.4612,1.48,0.0715,5062,0.42,"APC2, RAC1, SMAD2, MAPK9, APC, MAPK8, TGFBR2, MAPK1, MSH6, AKT1, KRAS, MSH2, RAF1, SMAD4, CYCS, MLH1, RHOA, FOS, AKT3, BAX, TGFB1, MSH3, BAD, SMAD3, CTNNB1, PIK3CB, AXIN1, BIRC5, APPL1, AXIN2",1.14569395819892,0.3767507096021,FALSE
+"H1703","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.33426,-1.22,0.186,14193,0.564,"C5, MASP1, C4A, SERPIND1, F10, VWF, KLKB1, PROC, A2M, PLAUR, SERPINA5, C4BPB, C1R, CFI, BDKRB1, SERPING1, SERPINA1, THBD, C2, CFB, CD46, C3, BDKRB2, CFH, CD55, PLAU, CD59, PLAT, F3",0.730487055782084,0.248720896016658,FALSE
+"H1703","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.26228,0.844,0.674,2883,0.816,"SMS, GOT1, CBS, DNMT1, AHCY, LDHB, SRM, MPST",0.17134010346468,0.0883098412461389,FALSE
+"H1703","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20201,0.656,0.925,1765,0.991,"PDGFRA, VEGFD, FLT4, PDGFC, GHR, PDGFB, CCR10, IL17RA, TNFSF12, LIFR, BMPR1A, OSMR, IL13RA1, CCL28, FLT3, CCL2, TNFRSF1A, TGFBR2, XCL1, IFNAR2, IFNGR2, IL6ST",0.0338582672609674,0.00392634551472468,FALSE
+"H1703","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26593,0.854,0.66,4584,0.803,"POLR3C, POLR3G, CHUK, NFKB1, IKBKG, POLR1C, CCL5, RIPK1, POLR3H, POLR3GL, NFKBIB, POLR3A, POLR3K, NFKBIA, IKBKE, IRF3, IL18",0.180456064458131,0.095284454721319,FALSE
+"H1703","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22761,-0.852,0.688,15983,0.762,"ADCY4, TNNT2, CACNA1C, ITGA11, CACNA2D3, CACNG6, RYR2, SLC8A1, TNNI3, ADCY9, CACNA1D, ITGB3, TGFB3, ADCY7, ITGA7, ITGB6, ITGA1, ITGB4, TGFB2, ITGB8, ITGA2",0.162411561764489,0.1180450286604,FALSE
+"H1703","Input","KEGG_DNA_REPLICATION",0.61996,2,0.00376,4068,0.147,"MCM5, RNASEH1, RPA1, POLA1, MCM3, POLD2, DNA2, RFC4, POLD1, PRIM2, RFC2, POLE, RNASEH2B, RFC1, LIG1, RNASEH2A, MCM2, POLE2",2.42481215507234,0.832682665251824,TRUE
+"H1703","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43423,1.41,0.087,5357,0.451,"SPIRE1, ETS1, CPEB1, GRB2, MAPK1, KRAS, SOS1, NOTCH2, SPIRE2, EGFR, NOTCH3, ETV6, FMN2",1.06048074738138,0.345823458122039,FALSE
+"H1703","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.25836,-0.971,0.466,14488,0.655,"CYP3A7, ADH1C, CYP2A6, GSTA1, GSTM2, UGT2B7, MAOB, CYP3A5, ALDH3B2, GSTM1, ALDH3A1, ALDH1A3, FMO4, AOX1, GSTT2, ALDH3B1, MAOA, MGST1, MGST2",0.33161408331,0.183758700008217,FALSE
+"H1703","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.19701,0.634,0.94,4066,0.992,"DPYS, HPRT1, UCK2, UPP2, IMPDH2, UMPS, GMPS, UPP1, CYP3A43",0.0268721464003014,0.00348832784582135,FALSE
+"H1703","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43845,-1.54,0.078,14804,0.456,"CHAD, COL4A1, VWF, RELN, ITGA10, VTN, THBS2, CD36, COL11A1, THBS4, ITGA11, COL4A4, COL3A1, COL6A3, COL4A6, COL4A2, LAMA1, SDC2, HSPG2, COL1A2, ITGB3, SPP1, ITGA7, ITGB6, COL5A1, ITGA1, LAMA4, SV2A, ITGB4, LAMA3, LAMC2, COL6A1, COL1A1, THBS1, FN1, TNC, ITGB8, ITGA2, LAMB3, LAMB1, CD44",1.10790539730952,0.341035157335565,FALSE
+"H1703","Input","KEGG_ENDOCYTOSIS",0.3005,0.952,0.503,4613,0.748,"PDGFRA, VTA1, GIT1, NEDD4, HSPA1L, PLD2, SMAP1, GRK3, PIP4K2B, GRK6, DNM1L, EPN2, NEDD4L, RAB31, PIP5K1A, SMURF2, CBL, RUFY1, SNF8, AP2B1, PDCD6IP, RAB4A, VPS4B, RAB5C, RAB11FIP2, ARRB2, STAM2, HSPA1A, RAB11B, ARFGAP3, RABEP1, IQSEC1, ACAP2, CLTB, AP2A1, ASAP1, SH3KBP1, RAB11FIP3, PARD6A, RBSN, CLTC, PRKCI, VPS36, RAB11A, RET, EPN1, CHMP3, SH3GLB2, CLTCL1, VPS45, PSD, CHMP4A, MVB12B, SH3GLB1, HSPA8, RAB11FIP1, CHMP6, CLTA, EGFR, HGS, FGFR3, HSPA1B",0.298432014944073,0.126098402135539,FALSE
+"H1703","Input","KEGG_ENDOMETRIAL_CANCER",0.36401,1.17,0.226,5062,0.565,"APC2, APC, GRB2, MAPK1, AKT1, KRAS, SOS1, RAF1, CTNNA1, NRAS, MAP2K2, PTEN, MLH1, AKT3, BAD, EGFR, CTNNB1, PIK3CB, AXIN1, AXIN2",0.645891560852599,0.247951552180562,FALSE
+"H1703","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37919,1.22,0.174,2474,0.576,"MAPK11, ATP6V1E2, MAPK12, GIT1, RAC1, MAP3K14, MAPK9, MAPK8, ATP6V1C1, PTPN11, CHUK, CSK, HBEGF, NFKB1, IKBKG, CCL5, JAM3",0.7594507517174,0.239577516576788,FALSE
+"H1703","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.31112,0.985,0.448,2591,0.699,"NRG2, EIF4EBP1, SHC1, PAK2, MAPK9, GRB2, CRKL, MAPK8, CBL, MTOR, MAPK1, CRK, HBEGF, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2",0.348721986001856,0.155522824254319,FALSE
+"H1703","Input","KEGG_ETHER_LIPID_METABOLISM",0.27546,0.892,0.613,2722,0.788,"PLD2, PAFAH1B1, PAFAH1B3, CHPT1, LPCAT1, LPCAT4",0.212539525481585,0.103473782510445,FALSE
+"H1703","Input","KEGG_FATTY_ACID_METABOLISM",0.23773,0.77,0.803,3816,0.895,"ALDH3A2, ECI1, HADHA, ADH5, ACAA2, CPT1A, ACADVL, ALDH9A1, ACAT1, HADHB, ACAT2",0.095284454721319,0.048176964684088,FALSE
+"H1703","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.3071,0.993,0.442,3676,0.698,"MAPK11, MAPK12, RAC1, MAPK9, GRB2, MAPK8, MAPK1, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, MAPK14, PRKCA, AKT3, MAP2K3",0.354577730650908,0.156144577376839,FALSE
+"H1703","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.21447,0.699,0.899,3567,0.963,"RAC1, PLD2, PIP4K2B, DNM1L, PIP5K1A, WASF1, CRKL, MAPK1, CRK, ARPC1B, VASP, AKT1, RAF1, RPS6KB1, WASF2, ASAP1, ARPC5, PRKCA, AKT3",0.0462403082667712,0.0163737128754655,FALSE
+"H1703","Input","KEGG_FOCAL_ADHESION",0.25566,0.823,0.719,2361,0.825,"PDGFRA, LAMC3, VEGFD, FLT4, PDGFC, CCND2, PDGFB, RAC1, SHC1, PAK2, MAPK9, COL5A2, MYL12B, VCL, ROCK1, BIRC3, GRB2, CRKL, MAPK8, BIRC2, TLN1, MAPK1, CRK, LAMB2, RAPGEF1, VASP, AKT1, XIAP, SOS1, RAF1, CAV2",0.143271109617117,0.0835460514500749,FALSE
+"H1703","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.40759,-1.51,0.0612,15242,0.405,"ALPG, PTS, ALPP, QDPR",1.21324857785444,0.392544976785331,FALSE
+"H1703","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.22928,-0.832,0.69,16156,0.762,"FBP1, AKR1B10, PFKFB4, MTMR7, MPI, HK2, ALDOC",0.161150909262745,0.1180450286604,FALSE
+"H1703","Input","KEGG_GALACTOSE_METABOLISM",-0.24419,-0.897,0.54,16354,0.706,"GCK, GLB1, B4GALT1, GALE, HK2, GAA",0.267606240177031,0.151195298948196,FALSE
+"H1703","Input","KEGG_GAP_JUNCTION",0.32643,1.05,0.367,3882,0.638,"PDGFRA, PDGFC, PDGFB, ITPR2, TUBB3, GRB2, PLCB3, PLCB4, ADCY3, MAPK1, TUBB4A, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKACA, TUBB6, CSNK1D, PRKCA, TUBB, GNA11, TUBB2B, TUBB2A, GNAI2",0.435333935747911,0.195179321278838,FALSE
+"H1703","Input","KEGG_GLIOMA",0.38173,1.23,0.166,3587,0.597,"PDGFRA, PDGFB, SHC1, GRB2, E2F2, MTOR, CALML6, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PTEN, PRKCA, AKT3, CALM3",0.779891911959945,0.224025668870631,FALSE
+"H1703","Input","KEGG_GLUTATHIONE_METABOLISM",-0.30408,-1.09,0.313,16922,0.651,"GPX2, ANPEP, GPX3, GPX7, GSTT2, RRM1, GGT7, MGST1, MGST2, GPX1",0.504455662453552,0.186419011431808,FALSE
+"H1703","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.27729,-1.02,0.403,18253,0.682,"DGKG, LIPG, GK, ALDH2, DGKA, PLPP3, MGLL",0.39469495385889,0.166215625343521,FALSE
+"H1703","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.27262,0.878,0.618,4530,0.802,"PLD2, PEMT, GNPAT, AGPAT1, LPCAT3, LCLAT1, LPGAT1, CHPT1, DGKZ, ETNK1, LPCAT1, LPCAT4, ETNK2, PTDSS1, MBOAT2, DGKH, ACHE, PCYT1A, PGS1, GPAT3, DGKQ, AGPAT4",0.209011524911184,0.0958256317158365,FALSE
+"H1703","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.38859,1.24,0.174,4438,0.589,"AOC2, AOC3, CBS, PSAT1, GCAT, PHGDH, PSPH, SRR, AMT, ALAS1",0.7594507517174,0.229884705212898,FALSE
+"H1703","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.27207,-1.01,0.393,16071,0.633,"LDHC, ALDH3B2, FBP1, GCK, AKR1A1, ALDH3A1, LDHAL6B, ALDH1A3, LDHA, ALDH3B1, HK2, ACSS1, ALDOC, ALDH2, GALM, ACSS2, ENO2",0.405607449624573,0.198596289982645,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.28899,0.938,0.523,2370,0.764,"CHST7, CHST13, CSGALNACT2, CHST3, B3GAT1",0.281498311132726,0.11690664142431,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.36305,-1.32,0.122,14466,0.519,"EXTL1, HS6ST3, HS6ST1, HS3ST5, NDST3, GLCE, EXT1, HS3ST3B1, HS3ST1, B3GALT6, EXTL3, EXTL2, EXT2",0.913640169325252,0.284832642151542,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.55485,-2.05,0,17207,0.227,"B3GNT7, B4GALT1, CHST6, B4GALT3, ST3GAL1, B4GAT1, B4GALT4",Inf,0.643974142806877,TRUE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.35272,-1.31,0.137,14399,0.506,"HYAL1, GNS, HEXA, GLB1, HGSNAT, HS3ST3B1, HPSE, NAGLU",0.863279432843593,0.295849483160201,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.36302,-1.4,0.107,15441,0.518,"HEXA, SLC33A1, ST6GALNAC3, GLB1, ST8SIA1, ST6GALNAC5, ST3GAL1, ST3GAL5",0.97061622231479,0.285670240254767,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.44206,-1.67,0.0343,16571,0.37,"FUT2, ST8SIA1, B3GALT5, GBGT1, ST3GAL1, FUT1, B3GALNT1",1.46470587995723,0.431798275933005,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.55655,-2.05,0.00939,14036,0.227,"FUT9, B3GALT2, FUT7, ST3GAL6, B3GALT1, ABO, FUT2, FUT3, ST8SIA1, B3GALT5, B4GALT1, B4GALT3, B3GNT3, FUT1, B4GAT1, B4GALT4, B3GNT5",2.02733440773389,0.643974142806877,TRUE
+"H1703","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.28154,-1.03,0.404,17741,0.679,"PIGM, PGAP1, PIGP, PIGH",0.393618634889395,0.168130225719498,FALSE
+"H1703","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.47917,1.53,0.0417,4607,0.429,"MTHFD1L, ACO2, MTHFD2, PGP, MTHFD1, GRHPR",1.37986394502624,0.367542707815276,FALSE
+"H1703","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.34007,1.07,0.354,3676,0.61,"MAPK11, MAPK12, ITPR2, PLD2, MAPK9, GRB2, GNRH2, MAPK8, PLCB3, CALML6, PLCB4, ADCY3, MAPK1, HBEGF, MAP3K4, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKACA, MAPK14, ATF4, PRKCA, CALM3, GNA11, MAP2K3",0.450996737974212,0.214670164989233,FALSE
+"H1703","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.50601,-1.87,0.0104,9878,0.347,"KLRD1, IFNG, KIR2DL1, CD28, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, TNF, FAS, CD86, GZMB, IL1A, IL6, IL1B",1.98296666070122,0.459670525209126,FALSE
+"H1703","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.33871,1.1,0.29,4313,0.599,"GLI1, BTRC, WNT5B, BMP6, RAB23, FBXW11, PTCH2, CSNK1A1, WNT6, PRKACA, BMP7, CSNK1D, CSNK1G3, ZIC2, CSNK1E, STK36, BMP8A, WNT2B",0.537602002101044,0.222573177610689,FALSE
+"H1703","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.35053,-1.28,0.147,15494,0.507,"KIT, CSF1R, CD36, FCGR1A, KITLG, CSF2, CD22, CD4, IL1A, IL6, IL1B, IL1R2, ANPEP, CD14, CSF2RA, ITGB3, IL11, ITGA1, IL6R, CD55, CD59, ITGA2, FLT3LG, CD44",0.832682665251824,0.294992040666664,FALSE
+"H1703","Input","KEGG_HISTIDINE_METABOLISM",-0.2891,-1.07,0.327,14856,0.672,"ACY3, AOC1, DDC, HEMK1, MAOB, ALDH3B2, ALDH3A1, ALDH1A3, LCMT2, ALDH3B1, MAOA, HNMT, ALDH2",0.485452247339714,0.172630726946175,FALSE
+"H1703","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.58066,1.87,0.00745,6162,0.195,"RPA1, RAD52, POLD2, RAD50, POLD1, RAD51, MUS81, MRE11, RAD54L, XRCC3, RAD51D, BRCA2, NBN, XRCC2, RAD54B, BLM, TOP3B, SEM1, EME1, RAD51C, POLD3",2.12784372725171,0.709965388637482,TRUE
+"H1703","Input","KEGG_HUNTINGTONS_DISEASE",0.32908,1.05,0.35,4251,0.638,"GRIN2B, NDUFS6, SDHA, NDUFA9, TBP, DLG4, TFAM, NDUFA1, ATP5F1A, VDAC2, TAF4B, COX7A2L, PPID, HIP1, POLR2J, PLCB3, EP300, AP2B1, PLCB4, TBPL1, NDUFS4, VDAC1, NDUFA3, POLR2E, SLC25A5, HDAC2, CYCS, SIN3A, CYC1, ATP5F1D, POLR2H, SDHB, POLR2F, TGM2, CLTB, AP2A1, POLR2B, NDUFS3, POLR2J2, SP1, NDUFA6, BAX, SOD2, NDUFA10, CLTC, NDUFB8, ATP5F1C, UQCRHL, CLTCL1, UQCRFS1, NDUFC1, DCTN1, POLR2A",0.455931955649724,0.195179321278838,FALSE
+"H1703","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.24638,-0.873,0.58,16198,0.744,"TNNT2, CACNA1C, ITGA11, CACNA2D3, CACNG6, RYR2, PRKAB1, SLC8A1, TNNI3, IL6, CACNA1D, ITGB3, ACE, TGFB3, ITGA7, ITGB6, ITGA1, ITGB4, TGFB2, ITGB8, ITGA2",0.236572006437063,0.128427064454121,FALSE
+"H1703","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.36842,1.19,0.22,4909,0.555,"OCRL, PIP4K2B, IMPA1, PIP5K1A, INPP5B, TPI1, PLCE1, PI4KB, PLCB3, PLCB4, INPP4B, PLCD4, PTEN, PIK3C3, INPP5J, ISYNA1, INPPL1, PLCG2, INPP5E, PIK3CB, IPMK",0.657577319177794,0.255707016877324,FALSE
+"H1703","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.34774,1.12,0.293,5499,0.636,"EIF4EBP1, SHC1, MAPK9, SOCS3, PRKAG2, PRKAA1, PHKA1, GRB2, PRKAR2A, CRKL, MAPK8, CBL, MTOR, FLOT1, CALML6, MAPK1, CRK, PRKAR2B, HK3, RAPGEF1, AKT1, KRAS, SOS1, RAF1, NRAS, RHOQ, ACACA, MAP2K2, PCK2, PRKACA, SOCS2, PHKA2, RPS6KB1, FLOT2, MKNK2, TRIP10, AKT3, CALM3, PRKCI, SREBF1, PPP1CC, BAD, EXOC7, FASN, PIK3CB, G6PC2, PRKAR1B, PDE3B, IKBKB, PYGL, RPTOR, TSC2, CALM1, ACACB, SH2B2, PRKAR1A, PRKCZ",0.533132379645891,0.196542884351586,FALSE
+"H1703","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.29937,0.951,0.507,2595,0.742,"CCR10, MAP3K14, CCL28, CD40, MADCAM1",0.294992040666664,0.129596094720973,FALSE
+"H1703","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.28043,0.883,0.619,2964,0.799,"CCND2, GHR, STAT3, PIAS3, LIFR, SOCS3, OSMR, IL13RA1, GRB2, CBL, PTPN11, EP300, IFNAR2, IFNGR2, IL6ST, SOCS7, PIAS2, LIF, TYK2, AKT1, SOS1, STAM2, SPRY3, SPRY4, IFNW1, SOCS2, LEPR",0.208309350979882,0.0974532206860086,FALSE
+"H1703","Input","KEGG_LEISHMANIA_INFECTION",0.29456,0.931,0.552,4257,0.753,"MAPK11, MAPK12, ITGAM, MAP3K7, IFNGR2, MAPK1, NFKB1, TAB1, IRAK1, MAPK14, JAK1, FOS, NFKBIB, TAB2, TGFB1, MYD88, NFKBIA",0.258060922270801,0.123205023799299,FALSE
+"H1703","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19966,0.643,0.941,4070,0.994,"MAPK11, MAPK12, RAC1, ITGAM, MYL12B, VCL, ROCK1, THY1, PTPN11, VASP, OCLN, CTNNA1, JAM3, AFDN, CLDN15, MAPK14, MYL12A, RHOA, PRKCA, PXN, MSN, GNAI2, BCAR1, SIPA1",0.0264103765727431,0.00261361560268669,FALSE
+"H1703","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.39056,1.24,0.171,4604,0.589,"ALDH3A2, HADHA, ALDH9A1, ALDH1B1",0.767003889607846,0.229884705212898,FALSE
+"H1703","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.27636,-0.999,0.422,11712,0.626,"CYP1A2, PLA2G2A, PLA2G5, PLA2G2C, CYP2E1, PLA2G2F, PLA2G4B, ALOX15, PLA2G4E, PLA2G6, CYP3A7, PLA2G3, CYP2J2, PLA2G10, CYP3A5, AKR1B10, PLA2G4A",0.374687549038326,0.20342566678957,FALSE
+"H1703","Input","KEGG_LONG_TERM_DEPRESSION",0.28316,0.908,0.593,2591,0.77,"CACNA1A, ITPR2, PPP2CA, GNA13, PLCB3, PLCB4, MAPK1, GNAZ, KRAS, RAF1, NRAS, MAP2K2",0.226945306635737,0.113509274827518,FALSE
+"H1703","Input","KEGG_LONG_TERM_POTENTIATION",0.35671,1.15,0.248,3587,0.6,"GRIN2B, ITPR2, RPS6KA6, PLCB3, EP300, CALML6, PLCB4, MAPK1, KRAS, PPP3R2, RAF1, NRAS, MAP2K2, PPP3CB, PRKACA, ATF4, PRKCA, CALM3",0.605548319173784,0.221848749616356,FALSE
+"H1703","Input","KEGG_LYSINE_DEGRADATION",0.3071,0.989,0.434,4958,0.698,"NSD3, ALDH3A2, HADHA, SETD2, NSD2, NSD1, TMLHE, SETDB2, ALDH9A1, OGDH, ACAT1, ACAT2, EHMT2, ALDH1B1, KMT5A, DOT1L",0.362510270487489,0.156144577376839,FALSE
+"H1703","Input","KEGG_LYSOSOME",-0.28575,-1.05,0.339,15828,0.697,"ATP6V0B, ATP6V0D1, GBA, SCARB2, ATP6V0A4, ABCB9, SORT1, LAPTM5, ACP5, GLB1, PLA2G15, HGSNAT, SLC11A2, CTSC, CTSB, CTSS, ATP6V1H, NEU1, AP1S3, NAGLU, CTSD, NPC2, CD63, GAA, FUCA1, ENTPD4, AP1M2, TPP1, MANBA, AP3S2, SMPD1, CTSH, ASAH1, CTSZ",0.469800301796918,0.156767221901991,FALSE
+"H1703","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.39106,1.26,0.162,3426,0.592,"PDGFRA, MAPK11, CACNA1A, FGF17, MAP3K20, PDGFB, NFKB2, MAPK12, RAC1, MEF2C, MAP3K14, RPS6KA6, MAPK8IP2, PAK2, CACNB1, HSPA1L, MAPK9, RELB, SRF, FGF2, FGF5, CACNA1G, FGFR1, MAP3K12, PPM1B, MAP3K7, DAXX, GRB2, ELK4, HSPB1, CRKL, MAPK8, TNFRSF1A, TGFBR2, FGF12, DUSP16, CHUK, CACNA1H, MAPK1, CRK, RPS6KA4, NFKB1, IKBKG, MAP3K4, CDC25B, TAB1, MAP4K2, AKT1, TAOK1, KRAS, FGF8, PPP3R2, SOS1, RAF1, NRAS, STK3, CACNA1B, ARRB2, MAP2K2, RRAS, HSPA1A, PPP3CB, MRAS, MAPK8IP1, PRKACA, NF1, MAPK14, NLK, MKNK2, ATF4, MAP3K6, FOS, PRKCA, CACNB4",0.790484985457369,0.22767829327708,FALSE
+"H1703","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.37293,-1.37,0.128,14279,0.535,"NR5A2, HNF4A, ONECUT1, FOXA3, HNF1B, BHLHA15, GCK, HNF4G, FOXA2, PAX6, HES1",0.892790030352132,0.271646217978772,FALSE
+"H1703","Input","KEGG_MELANOGENESIS",-0.20407,-0.756,0.821,15276,0.866,"EDNRB, CAMK2B, CAMK2A, KIT, TYRP1, WNT7B, WNT7A, ADCY4, KITLG, WNT10A, TCF7L2, WNT11, WNT3, ADCY9, CREB3L4, LEF1, ADCY7, FZD9, MITF, FZD4, CREB3L1, FZD8, PLCB2, WNT5A, FZD7, EDN1, HRAS, PLCB1, CREB3L2, FZD3",0.0856568428805592,0.0624821079826534,FALSE
+"H1703","Input","KEGG_MELANOMA",0.42035,1.33,0.12,2759,0.541,"PDGFRA, FGF17, PDGFC, PDGFB, FGF2, FGF5, FGFR1, E2F2, FGF12, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, FGF8, RAF1, NRAS, MAP2K2, PTEN",0.920818753952375,0.266802734893431,FALSE
+"H1703","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.31784,-1.17,0.237,14488,0.569,"CYP3A7, ADH1C, GSTA1, DHDH, GSTM2, UGT2B7, CYP3A5, ALDH3B2, AKR1C1, GSTM1, ALDH3A1, ALDH1A3, AKR1C2, CYP1B1, GSTT2, AKR1C3, ALDH3B1, CYP1A1, CYP2S1, MGST1, MGST2",0.625251653989896,0.244887733604929,FALSE
+"H1703","Input","KEGG_MISMATCH_REPAIR",0.66301,2.15,0.0025,4127,0.152,"PMS2, RPA1, POLD2, MSH6, RFC4, POLD1, MSH2, RFC2, EXO1, MLH1, RFC1, LIG1, MSH3",2.60205999132796,0.818156412055227,TRUE
+"H1703","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.39377,1.26,0.153,3567,0.592,"VEGFD, EIF4EBP1, RPS6KA6, PRKAA1, STK11, ULK2, MTOR, MAPK1, AKT1, ULK1, RPS6KB1, MLST8, RICTOR, AKT3",0.815308569182401,0.22767829327708,FALSE
+"H1703","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.28633,0.93,0.547,2705,0.739,"KLRK1, NFATC1, RAC1, KLRC2, SHC1, KLRC3, MICA, GRB2, PTPN11, IFNAR2, IFNGR2, MAPK1, MICB, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, BID, PPP3CB",0.262012673666569,0.131355561605174,FALSE
+"H1703","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.26553,0.865,0.645,1739,0.821,"GRIN2B, GRIN3B, S1PR1, GABRD, TBXA2R, CHRM4, GHR, C5AR1, AVPR2, P2RY4, GABRQ, S1PR5, GHSR, MC5R, ADORA2A, HRH1, LPAR2, GABRR2, TRHR, TRPV1, PTGER4, CRHR2, GRM6, GABBR1, CHRNA5",0.190440285364732,0.0856568428805592,FALSE
+"H1703","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.35215,1.13,0.276,5783,0.624,"MAPK11, MAPK12, RAC1, SHC1, RPS6KA6, MAPK9, NFKBIE, YWHAH, GRB2, CRKL, MAPK8, PTPN11, CALML6, CSK, MAPK1, CRK, RPS6KA4, NFKB1, RAPGEF1, AKT1, KRAS, YWHAE, SOS1, RAF1, NRAS, IRAK1, MAP2K2, MAPK14, RHOA, ATF4, AKT3, CALM3, BAX, NFKBIB, YWHAQ, RIPK2, NFKBIA, PLCG2, BAD, CAMK2G, MAPK7, PIK3CB, IRAK2, IKBKB, ZNF274, YWHAG, CALM1, SH2B2, NTF4, CDC42, KIDINS220, ABL1, BEX3",0.559090917934782,0.204815410317576,FALSE
+"H1703","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.23279,-0.854,0.669,14031,0.772,"QPRT, ENPP3, ENPP1, BST1, NMNAT2, AOX1, NMNAT3, NNT",0.174573882232177,0.112382699664264,FALSE
+"H1703","Input","KEGG_NITROGEN_METABOLISM",-0.27506,-1.01,0.405,17266,0.633,"CA9, GLS2, CA12, CPS1, CTH",0.392544976785331,0.198596289982645,FALSE
+"H1703","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.41774,1.35,0.108,3992,0.517,"NLRC4, MAPK11, MAPK12, MAPK9, HSP90AB1, ERBIN, BIRC3, MAP3K7, MAPK8, CCL2, BIRC2, CHUK, MAPK1, NFKB1, IKBKG, TAB1, XIAP, CCL5, MAPK14, SUGT1, NFKBIB, NAIP, TAB2, RIPK2",0.96657624451305,0.286509456906058,FALSE
+"H1703","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.62191,2.02,0.00247,4017,0.192,"XRCC6, RAD50, PRKDC, MRE11, POLL, XRCC4, LIG4",2.60730304674033,0.71669877129645,TRUE
+"H1703","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.31299,1.02,0.409,4830,0.671,"GRB2, E2F2, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKCA, AKT3, RB1, PLCG2, BAD, EGFR, PIK3CB",0.388276691992658,0.173277479831008,FALSE
+"H1703","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.31269,1.01,0.44,4661,0.676,"APH1A, NUMBL, EP300, KAT2A, HDAC2, CTBP1, KAT2B, NOTCH2, DVL1, DVL2, MAML1, JAG2, ADAM17, NCOR2, CTBP2, DLL3, PSEN2, DVL3, CREBBP, NOTCH3, MFNG",0.356547323513813,0.170053304058364,FALSE
+"H1703","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.43379,1.39,0.0898,6239,0.451,"GTF2H5, RPA1, GTF2H2, CUL4A, POLD2, RFC4, POLD1, RFC2, POLE, CUL4B, RFC1, LIG1, POLE2, ERCC2, ERCC8, CETN2, RBX1, RAD23A, CDK7, POLD3, ERCC1",1.0467236633327,0.345823458122039,FALSE
+"H1703","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.26286,-0.93,0.52,17042,0.682,"ALG9, RPN2, B4GALT1, B4GALT3, MAN1C1, ALG10B, MAN1B1, MOGS, MAN1A1, DOLPP1",0.283996656365201,0.166215625343521,FALSE
+"H1703","Input","KEGG_OLFACTORY_TRANSDUCTION",0.23183,0.756,0.809,700,0.901,"OR4A47, OR2V2, OR4S1, GNAL, OR2H2, OR2A5, GRK3, OR4F16",0.0920514783877277,0.045275209020937,FALSE
+"H1703","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.53985,1.71,0.0183,2373,0.345,"FTCD, MTHFD1L, ATIC, TYMS, GART, MTHFD2",1.73754891026957,0.462180904926726,FALSE
+"H1703","Input","KEGG_OOCYTE_MEIOSIS",0.4335,1.4,0.0955,4685,0.45,"PPP2R5A, MAPK12, ITPR2, BTRC, RPS6KA6, PPP2CA, CPEB1, MAD2L2, YWHAH, ESPL1, FBXW11, FBXO43, CALML6, PPP2R5D, ADCY3, MAPK1, SLK, SGO1, PPP3R2, YWHAE, CDC20, CCNB1, PPP3CB, PRKACA, SMC1B, CDC27, PTTG2, PPP2R5E, ANAPC1, ANAPC7, ANAPC4, PKMYT1, CDC23, CALM3, YWHAQ, FBXO5, PLK1, PPP1CC, BUB1, CCNE2, SMC3, CAMK2G, SMC1A",1.01999662841625,0.346787486224656,FALSE
+"H1703","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.4118,-1.51,0.0952,15441,0.405,"HEXA, GBA, GLB1, NEU1, FUCA1, MANBA",1.02136305161553,0.392544976785331,FALSE
+"H1703","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.21251,0.685,0.896,4989,0.97,"ATP6V1E2, NDUFS6, SDHA, NDUFA9, NDUFA1, ATP5F1A, COX7A2L, ATP6V1C1, NDUFS4, COX15, NDUFA3, CYC1, COX10, ATP5F1D, SDHB, COX11, NDUFS3, NDUFA6, NDUFA10, NDUFB8, ATP5F1C, UQCRHL, UQCRFS1, NDUFC1, TCIRG1, ATP6V0A1, COX7C, ATP5PD, UQCRC1",0.0476919903378748,0.0132282657337552,FALSE
+"H1703","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.33721,1.07,0.328,301,0.61,"GALNT8, GALNT13",0.484126156288321,0.214670164989233,FALSE
+"H1703","Input","KEGG_P53_SIGNALING_PATHWAY",0.34936,1.11,0.282,5416,0.616,"CCNB3, ADGRB1, CCND2, CHEK2, SHISA5, TP53I3, EI24, CDKN2A, SERPINE1, CYCS, GTSE1, CCNB1, BID, PTEN, SESN2, RRM2, COP1, CHEK1, RRM2B, BAX, SIAH1, IGFBP3, ATM, CCNE2, STEAP3, GADD45B, CDK2, CCND3, TSC2, ATR",0.549750891680639,0.210419287835575,FALSE
+"H1703","Input","KEGG_PANCREATIC_CANCER",0.4332,1.41,0.0831,2400,0.451,"VEGFD, RAC1, SMAD2, STAT3, MAPK9, RALBP1, E2F2, MAPK8, TGFBR2, CHUK, MAPK1, E2F3, NFKB1, E2F1, RAD51, IKBKG, CDKN2A, AKT1, KRAS, RAF1, SMAD4",1.08039897621589,0.345823458122039,FALSE
+"H1703","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.18878,-0.689,0.878,14406,0.922,"ENPP3, VNN1, ENPP1, VNN2, DPYD, BCAT1",0.0565054840938974,0.0352690789463706,FALSE
+"H1703","Input","KEGG_PARKINSONS_DISEASE",0.2881,0.925,0.553,5778,0.742,"NDUFS6, UBE2G1, SDHA, NDUFA9, NDUFA1, ATP5F1A, VDAC2, COX7A2L, PPID, UBE2J1, UCHL1, NDUFS4, VDAC1, NDUFA3, SLC25A5, CYCS, CYC1, ATP5F1D, SDHB, NDUFS3, NDUFA6, NDUFA10, NDUFB8, ATP5F1C, UBE2J2, UBE2L3, UQCRHL, UQCRFS1, NDUFC1, UBE2G2, COX7C, ATP5PD, UQCRC1, UBB, UQCR11, NDUFV3, COX6C, VDAC3, UQCRB, ATP5MC1, NDUFAB1",0.257274868695302,0.129596094720973,FALSE
+"H1703","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.25677,0.824,0.723,6351,0.831,"ROCK1, TUBB3, ARPC1B, TUBB4A, OCLN, NCL, TUBB6, RHOA, ARPC5, PRKCA, TUBB, TUBB2B, YWHAQ, TUBB2A, ARPC1A, CTNNB1, ROCK2, ACTB, CDC42, CLDN1, ABL1, TUBA1A, ITGB1, ARPC5L, YWHAZ",0.140861702705469,0.080398976215889,FALSE
+"H1703","Input","KEGG_PATHWAYS_IN_CANCER",0.29938,0.954,0.509,4615,0.753,"PDGFRA, LAMC3, FGF17, VEGFD, APC2, GLI1, PDGFB, NFKB2, RAC1, SMAD2, STAT3, WNT5B, PIAS3, ARNT, MAPK9, HSP90AB1, ETS1, RALBP1, FGF2, FGF5, FGFR1, BIRC3, TRAF3, APC, GRB2, FLT3, E2F2, CRKL, MAPK8, CBL, MTOR, EGLN1, BIRC2, PTCH2, TGFBR2, EP300, FGF12, VHL, CHUK, MAPK1, CRK, MSH6, E2F3, NFKB1, CCDC6, LAMB2, E2F1, RAD51, IKBKG, PIAS2, CDKN2A, TPM3, AKT1, XIAP, KRAS, FGF8, HDAC2, SOS1, MSH2, RAF1, CTNNA1, CTBP1, NRAS, SMAD4, CYCS, MAP2K2, BID, DVL1, PTEN, DVL2, WNT6, MLH1, RHOA, BRCA2, JAK1, FOS, PRKCA, AKT3, BAX, TRAF1, TRAF5, RB1, LAMA5, TGFB1, CTBP2, RET, STK36, MSH3, DAPK3, TRAF2, NFKBIA, WNT2B, DVL3, PLCG2, ELOC, BAD, CUL2, CREBBP, CCNE2, EGFR, SMAD3, CTNNB1, FGFR3, EGLN2",0.293282217663241,0.123205023799299,FALSE
+"H1703","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.19084,-0.688,0.9,11600,0.908,"UGT2B4, UGT2B17, UGT2A3, UGT2A1, UGT2B15, UGP2, DHDH, UGT2B7, DCXR, UGDH",0.0457574905606751,0.0419141514789149,FALSE
+"H1703","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.27662,-1.04,0.386,17989,0.677,"H6PD, ALDOC, TALDO1",0.413412695328245,0.169411331314856,FALSE
+"H1703","Input","KEGG_PEROXISOME",0.21494,0.7,0.873,4109,0.97,"PEX5, PEX16, HACL1, SLC25A17, DECR2, GNPAT, PEX26, AMACR, MPV17, PHYH, PEX6, PEX3, PXMP2, ABCD2, SOD2, PXMP4, AGPS, CRAT",0.0589857562944303,0.0132282657337552,FALSE
+"H1703","Input","KEGG_PHENYLALANINE_METABOLISM",0.37676,1.2,0.197,1522,0.556,"AOC2, AOC3, GOT1",0.705533773838407,0.254925208417942,FALSE
+"H1703","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.34267,1.11,0.304,4486,0.616,"OCRL, ITPR2, PIP4K2B, IMPA1, PIP5K1A, INPP5B, PLCE1, PI4KB, PLCB3, CALML6, PLCB4, DGKZ, INPP4B, PLCD4, PTEN, PIK3C3, INPP5J, PRKCA, CALM3, INPPL1, DGKH, PLCG2, INPP5E, DGKQ",0.517126416391246,0.210419287835575,FALSE
+"H1703","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.3162,1.03,0.383,3089,0.657,"HMOX1, FECH, COX15, COX10, FTH1",0.416801226031377,0.182434630440219,FALSE
+"H1703","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.3797,-1.35,0.126,13054,0.535,"CYP8B1, CYP7A1, PCK1, APOA1, CPT1B, FABP1, ACSL1, HMGCS2, RXRG, ACSL6, FABP4, CYP4A22, DBI, APOA2, SLC27A6, ACSL3, FABP7, AQP7, EHHADH, ACOX1, LPL, PPARA, OLR1, SORBS1, ACADL, CD36, CYP27A1, FABP3, FADS2, SCP2, ILK, ACOX2, FABP6, ACSL5, CPT1C, SLC27A2, CPT2, GK, PLTP, ME1",0.899629454882437,0.271646217978772,FALSE
+"H1703","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.32686,-1.21,0.211,16280,0.56,"CYP7B1, CYP27A1, SCP2, CYP39A1, ACOX2",0.675717544702307,0.2518119729938,FALSE
+"H1703","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.37858,1.22,0.183,3722,0.576,"TAP2, RFX5, TAP1, IKBKG, ADA, UNG, CD40, RFXANK, RFXAP",0.737548910269571,0.239577516576788,FALSE
+"H1703","Input","KEGG_PRION_DISEASES",0.1923,0.619,0.961,3665,0.994,"MAPK1, CCL5, MAP2K2, HSPA1A, PRKACA, BAX",0.0172766123314547,0.00261361560268669,FALSE
+"H1703","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.45689,1.48,0.0605,3567,0.42,"CCNB3, MAPK11, MAPK12, RPS6KA6, MAPK9, HSP90AB1, CPEB1, MAD2L2, MAPK8, ADCY3, MAPK1, CDC25B, AKT1, KRAS, RAF1, CDC25A, CCNB1, PRKACA, CDC27, MAPK14, ANAPC1, ANAPC7, CCNA2, ANAPC4, FZR1, PKMYT1, CDC23, AKT3",1.21824462534753,0.3767507096021,FALSE
+"H1703","Input","KEGG_PROPANOATE_METABOLISM",-0.39651,-1.42,0.0686,16714,0.521,"HIBCH, LDHAL6B, ACSS3, LDHA, ABAT, ACSS1, MLYCD, ALDH2, MCEE, ACSS2, ALDH6A1",1.16367588429325,0.283162276700476,FALSE
+"H1703","Input","KEGG_PROSTATE_CANCER",0.3573,1.14,0.273,2759,0.612,"PDGFRA, PDGFC, PDGFB, HSP90AB1, SRD5A2, FGFR1, GRB2, E2F2, MTOR, EP300, CHUK, MAPK1, E2F3, NFKB1, E2F1, IKBKG, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PTEN",0.563837352959244,0.213248577854439,FALSE
+"H1703","Input","KEGG_PROTEASOME",0.38944,1.26,0.149,5852,0.592,"PSMD4, PSMB4, PSMB9, PSME3, PSMC5, PSMD12, PSMF1, PSMD1, PSMA2, PSMD14, PSMD3, PSMB10, PSMD11, PSMD2, PSMA5, PSMB8, PSMA4, PSMC2, PSMB1, SEM1, PSME2",0.826813731587726,0.22767829327708,FALSE
+"H1703","Input","KEGG_PROTEIN_EXPORT",0.37758,1.21,0.209,3938,0.571,"SEC63, SRP19, SRP9, SRP72, SEC61A2, SEC11C, SRP68, SRPRB",0.679853713888946,0.243363891754152,FALSE
+"H1703","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.14865,0.478,0.998,4853,0.998,"PCK2, ATP1A3, GLUD1, SLC25A10, SLC9A3",0.000869458712628891,0.000869458712628891,FALSE
+"H1703","Input","KEGG_PURINE_METABOLISM",0.36229,1.17,0.216,4293,0.565,"PDE4A, NT5C2, POLR3C, PFAS, ADSL, POLR3G, ADK, PRPS1, PDE6C, POLA1, ATIC, HPRT1, NME4, NME2, ENTPD8, POLR1E, POLD2, POLR2J, GART, ADCY3, POLD1, NME1, POLR1C, ADA, POLR2E, NUDT5, PRUNE1, PRIM2, AMPD2, NME6, POLR3H, IMPDH2, GUK1, POLR2H, POLR2F, RRM2, PDE9A, GMPS, POLE, ENTPD1, POLR2B, POLR2J2, DCK, POLR3GL, RRM2B, PDE10A, PAICS, POLR3A, POLR3K, POLE2, PAPSS2, NUDT2, POLR2A, NME3",0.665546248849069,0.247951552180562,FALSE
+"H1703","Input","KEGG_PYRIMIDINE_METABOLISM",0.50444,1.61,0.0298,4293,0.452,"NT5C2, TXNRD1, POLR3C, POLR3G, CAD, POLA1, CTPS1, DPYS, NME4, NME2, TYMS, ENTPD8, POLR1E, POLD2, POLR2J, UCK2, POLD1, NME1, POLR1C, UPP2, POLR2E, PRIM2, NME6, POLR3H, UMPS, POLR2H, POLR2F, RRM2, DCTD, DUT, POLE, UPRT, ENTPD1, POLR2B, POLR2J2, DCK, POLR3GL, RRM2B, POLR3A, UPP1, POLR3K, POLE2, NUDT2, POLR2A, NME3",1.52578373592374,0.344861565188618,FALSE
+"H1703","Input","KEGG_PYRUVATE_METABOLISM",-0.27456,-1,0.43,18483,0.639,"ACSS1, ALDH2, ACSS2, ME1, PC",0.366531544420413,0.1944991418416,FALSE
+"H1703","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.34257,1.1,0.299,3352,0.599,"PDGFRA, FGF17, APC2, PDGFC, CHRM4, PDGFB, GIT1, RAC1, ITGAM, PFN1, PAK2, PFN4, ENAH, MYL12B, PIP4K2B, VCL, ROCK1, FGF2, FGF5, SSH1, FGFR1, PIP5K1A, WASF1, APC, GNA13, CRKL, FGF12, TMSB4Y, CSK, MAPK1, CRK, CYFIP1, ARPC1B, KRAS, FGF8, SOS1, RAF1, NRAS, MYH9, MAP2K2, RRAS, MRAS, FGD1, DIAPH3, IQGAP1, WASF2, MYL12A, DOCK1, RHOA, ARPC5",0.52432881167557,0.222573177610689,FALSE
+"H1703","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.45818,1.46,0.0764,3091,0.395,"ATG5, ATG7, PRKAA1, ULK2, ULK1, GABARAPL1, BECN1, PIK3C3",1.11690664142431,0.40340290437354,FALSE
+"H1703","Input","KEGG_RENAL_CELL_CARCINOMA",0.39768,1.28,0.139,2591,0.62,"VEGFD, PDGFB, RAC1, ARNT, PAK2, ETS1, GRB2, CRKL, EGLN1, PTPN11, EP300, VHL, MAPK1, CRK, RAPGEF1, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2",0.856985199745905,0.207608310501746,FALSE
+"H1703","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32245,1.01,0.432,1261,0.676,"NLN, LNPEP",0.364516253185088,0.170053304058364,FALSE
+"H1703","Input","KEGG_RETINOL_METABOLISM",-0.22451,-0.831,0.633,11025,0.751,"UGT2B11, CYP4A11, DHRS4L2, ADH6, CYP2A13, ADH1B, RDH8, UGT2B4, ADH7, UGT2B17, CYP1A2, ADH1A, UGT2A3, AWAT2, UGT2A1, UGT2B15, CYP2A7, RDH10, CYP2B6, RPE65, CYP4A22, CYP3A7, ADH1C, CYP2A6, RDH16, RDH5, UGT2B7, RETSAT, DHRS9, CYP3A5, BCO1, LRAT, ALDH1A2, CYP1A1, CYP26B1, RDH11, DHRS3",0.198596289982645,0.124360062995832,FALSE
+"H1703","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.20606,-0.744,0.836,3935,0.872,"MTMR1, ACP6, MTMR6, RFK, ACP1, FLAD1, ACP2, ACP4, PHPT1, MTMR2, TYR, ENPP3, ENPP1, ACP5, MTMR7",0.0777937225609836,0.0594835150674328,FALSE
+"H1703","Input","KEGG_RIBOSOME",-0.25121,-0.927,0.528,15661,0.673,"RPS8, RPL10A, RPL18, RPL7A, RPL35, RPL31, RPS3, RPL37A, RPL24, RPS15A, RPL29, RPS21, RPS6, RPS19, RPS27, RPS11, RPL13A, RPS9, RPLP2, RPS13, RPL27A",0.277366077466188,0.171984935776023,FALSE
+"H1703","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38127,1.21,0.198,4518,0.571,"MAPK11, MAPK12, ATG5, DDX3Y, MAPK9, MAP3K7, TRAF3, MAPK8, CHUK, TBKBP1, AZI2, NFKB1, IKBKG, RIPK1, IFNW1, MAPK14, TRIM25, DHX58, NFKBIB, TRAF2, NFKBIA, IKBKE, SIKE1, ATG12, IRF3",0.703334809738469,0.243363891754152,FALSE
+"H1703","Input","KEGG_RNA_DEGRADATION",0.48273,1.56,0.0354,6697,0.434,"LSM1, EXOSC1, TENT4A, MTREX, HSPA9, EXOSC7, EXOSC3, DCP1B, CNOT10, LSM4, EDC4, ENO1, LSM2, EXOSC10, DCP2, EXOSC2, LSM6, EXOSC8, ZCCHC7, PAPOLB, LSM5, LSM3, PAPOLA, XRN1, SKIV2L, LSM7, EXOSC6, TTC37, EXOSC4, PARN, CNOT8, EXOSC9, CNOT9, XRN2, ENO3, CNOT1, PATL1, CNOT6",1.45099673797421,0.362510270487489,FALSE
+"H1703","Input","KEGG_RNA_POLYMERASE",0.53681,1.75,0.0214,4251,0.322,"POLR3C, POLR3G, POLR1E, POLR2J, POLR1C, POLR2E, POLR3H, POLR2H, POLR2F, POLR2B, POLR2J2, POLR3GL, POLR3A, POLR3K, POLR2A",1.66958622665081,0.492144128304169,FALSE
+"H1703","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.2498,0.807,0.746,4494,0.838,"SEPHS1, CBS, BUD23, AHCY, PAPSS2, METTL6, SCLY",0.127261172527331,0.0767559813697235,FALSE
+"H1703","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.26392,0.857,0.649,6164,0.805,"LAMC3, PIAS3, BIRC3, TRAF3, E2F2, BIRC2, CHUK, E2F3, NFKB1, LAMB2, E2F1, IKBKG, PIAS2, AKT1, XIAP, CYCS, PTEN, AKT3, TRAF1, TRAF5, RB1, LAMA5, TRAF2, NFKBIA, CCNE2, PIK3CB, CDKN1B, IKBKB, CDK2, PIAS4, PIAS1, ITGAV, ITGA3, RELA, CKS1B, TRAF4, ITGB1",0.187755303199631,0.0942041196321315,FALSE
+"H1703","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.3296,1.07,0.331,4551,0.61,"VAMP7, VAMP1, STX10, SNAP29, STX6, STX4, STX8, SNAP47, STX2, STX11, VTI1B, YKT6, GOSR2, VAMP2, STX1B, STX7",0.480172006224281,0.214670164989233,FALSE
+"H1703","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.20482,-0.774,0.765,18902,0.849,"PLPP3, SMPD1, ASAH1",0.116338564846382,0.0710923097560473,FALSE
+"H1703","Input","KEGG_SPLICEOSOME",0.58676,1.89,0.00623,4883,0.218,"MAGOHB, WBP11, SF3B4, TXNL4A, HSPA1L, PLRG1, RBM8A, PRPF8, THOC1, SNU13, RBM22, SNRPC, RBM17, SNRPD1, DHX16, HNRNPU, PRPF3, U2SURP, EFTUD2, DDX39B, ZMAT2, BUD31, SF3B5, ALYREF, PHF5A, SRSF1, HNRNPM, DDX46, PPIH, SF3A1, SNRPD3, LSM4, SRSF7, DDX42, CDC5L, SRSF3, CDC40, CCDC12, PPIL1, HSPA1A, SNRNP40, TCERG1, HNRNPA3, RBM25, LSM2, PUF60, THOC2, PRPF18, SMNDC1, LSM6, U2AF2, PRPF31, SNRPE, SRSF9, LSM5, TRA2A, NCBP1, DHX38, SART1, PRPF40A, PRPF40B, HSPA8, LSM3, U2AF1, SRSF2, HSPA1B, EIF4A3, SRSF4, AQR, SNRNP70, PRPF4, PQBP1",2.20551195334083,0.661543506395395,TRUE
+"H1703","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.33823,-1.23,0.193,11025,0.574,"UGT2B11, AMY1C, AMY1A, PGM2, GBE1, UGT2B4, UGT2B17, MGAM, UGT2A3, UGT2A1, AMY2B, UGT2B15, PYGB, UXS1, PYGM, GYS1, TREH, UGP2, GANC, ENPP3, ENPP1, AGL, UGT2B7, GCK, UGDH, HK2, PGM2L1, GAA",0.714442690992226,0.241088107602027,FALSE
+"H1703","Input","KEGG_STEROID_BIOSYNTHESIS",0.34437,1.1,0.304,1535,0.599,"SOAT1, CYP27B1, NSDHL",0.517126416391246,0.222573177610689,FALSE
+"H1703","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.31975,-1.16,0.271,15701,0.568,"CYP19A1, UGT2B7, CYP11A1, CYP3A5, AKR1C1, CYP7B1, HSD17B2, HSD11B2, HSD17B7, AKR1C2, STS, CYP1B1, HSD17B12, AKR1C3, CYP1A1, HSD17B8",0.567030709125594,0.245651664288981,FALSE
+"H1703","Input","KEGG_SULFUR_METABOLISM",-0.25162,-0.972,0.468,16233,0.669,"BPNT1, SULT1A2, SULT1A4, SULT1A1",0.329754146925876,0.174573882232177,FALSE
+"H1703","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.33097,1.08,0.322,2327,0.625,"GRIN2B, ELANE, SNRPD1, CD40, SNRPD3",0.492144128304169,0.204119982655925,FALSE
+"H1703","Input","KEGG_TASTE_TRANSDUCTION",0.49432,1.6,0.0281,1140,0.429,"TAS2R9, TAS2R7, TAS2R10, CACNA1A, TAS2R8, GNG13, TAS2R13",1.55129368009492,0.367542707815276,FALSE
+"H1703","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.45807,-1.71,0.0273,15251,0.372,"GGT6, GGT5, CDO1, GGT7",1.56383735295924,0.429457060118102,FALSE
+"H1703","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.34401,1.11,0.283,4402,0.616,"PDSS2, ACAT1, ACAT2, GGPS1, HMGCS1",0.54821356447571,0.210419287835575,FALSE
+"H1703","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28573,0.931,0.545,5434,0.753,"SMAD2, NOG, BMPR1A, PPP2CA, ROCK1, BMP6, SMURF2, TGFBR2, EP300, MAPK1, SMAD4, SMAD1, CHRD, ZFYVE16, E2F5, BMP7, RPS6KB1, RHOA, SP1, ID3, TGFB1, BMP8A, CREBBP, SMAD3, SMURF1, SMAD5, ID1, ROCK2, BMPR2, TFDP1, RBX1, E2F4",0.263603497723358,0.123205023799299,FALSE
+"H1703","Input","KEGG_THYROID_CANCER",0.2996,0.961,0.496,2591,0.746,"MAPK1, CCDC6, TPM3, KRAS, NRAS, MAP2K2",0.304518323509803,0.127261172527331,FALSE
+"H1703","Input","KEGG_TIGHT_JUNCTION",0.26716,0.857,0.66,4727,0.805,"MYH2, MAP3K20, PPP2R2C, EXOC3, MYL12B, PPP2CA, VAPA, TJAP1, YBX3, AKT1, KRAS, OCLN, CSNK2B, CTNNA1, NRAS, MYH3, JAM3, MYH9, RRAS, AFDN, MRAS, PTEN, CLDN15, YES1, RAB3B, MYL12A, RHOA, EPB41L2, PRKCA, PARD6A, AKT3, PRKCI, GNAI2, MYH1, LLGL1, MYH10, SYMPK, PRKCQ, CTNNB1, CGN",0.180456064458131,0.0942041196321315,FALSE
+"H1703","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31496,1,0.422,4518,0.69,"MAPK11, MAPK12, RAC1, MAPK9, MAP3K7, TRAF3, MAPK8, IFNAR2, CHUK, MAPK1, NFKB1, IKBKG, TAB1, CD40, AKT1, CCL5, RIPK1, IRAK1, MAP2K2, MAPK14, TICAM1, FOS, AKT3, MAP2K3, TAB2, MYD88, CTSK, NFKBIA, IKBKE, IRF5, IRF3",0.374687549038326,0.161150909262745,FALSE
+"H1703","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.29761,-1.1,0.311,14864,0.651,"EHHADH, AADAT, AOC1, AFMID, IDO1, DDC, IL4I1, KMO, MAOB, OGDHL, AOX1, CYP1B1, CYP1A1, MAOA, ALDH2, CAT",0.507239610973163,0.186419011431808,FALSE
+"H1703","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.36991,1.2,0.203,3347,0.556,"CACNA1A, MAPK9, SOCS3, CACNA1G, MAPK8, MTOR, MAPK1, HK3, CACNA1B, SOCS2, MAFA",0.692503962086787,0.254925208417942,FALSE
+"H1703","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.25506,-0.939,0.481,14053,0.692,"TNF, FAS, CD86, CPE, GZMB, IL1A, PTPRN2, IL1B",0.317854923626168,0.159893905543242,FALSE
+"H1703","Input","KEGG_TYROSINE_METABOLISM",0.27013,0.859,0.639,1909,0.817,"AOC2, AOC3, GOT1, BUD23, ADH5",0.1944991418416,0.0877779434675845,FALSE
+"H1703","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.37218,1.19,0.21,3697,0.555,"MALT1, MAPK11, MAPK12, NFATC1, MAP3K14, PAK2, MAPK9, NFKBIE, MAP3K7, GRB2, CBL, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, PPP3CB, MAPK14, RHOA, FOS, AKT3, NFKBIB",0.677780705266081,0.255707016877324,FALSE
+"H1703","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.39987,1.29,0.145,5645,0.617,"HERC4, UBE2G1, BTRC, NEDD4, TRIM37, PIAS3, FBXO2, SOCS3, UBE2K, NEDD4L, UBE2D2, BIRC3, SMURF2, TRIP12, UBE2A, CUL4A, CBL, FBXW11, BIRC2, CDC34, VHL, UBE2J1, PIAS2, BRCA1, XIAP, CDC20, BIRC6, UBE2R2, UBA2, CDC27, UBE2D1, COP1, UBE2Z, ANAPC1, NHLRC1, CUL4B, ANAPC7, ANAPC4, FZR1, PPIL2, CDC23, UBE2E1, UBE2E2, SIAH1, UBE2S, UBE2J2, UBE2L3, UBE2Q1, CUL7, ELOC, CUL2, UBE2B, UBE2G2, SMURF1, ERCC8, UBE2M, UBE4B, UBR5, ELOB, RBX1, PIAS4, FBXW7, UBE2D4, PIAS1, CDC16, ITCH, UBE2D3, CUL3",0.838631997765025,0.209714835966758,FALSE
+"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.45454,1.46,0.0591,4778,0.395,"PDHA1, IARS2, BCAT2, VARS2",1.22841251911874,0.40340290437354,FALSE
+"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.33547,-1.28,0.121,17618,0.507,"AOX1, ABAT, DBT, BCAT1, ALDH2, MCEE, ACADS, ALDH6A1",0.91721462968355,0.294992040666664,FALSE
+"H1703","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.1626,0.534,0.996,3616,1,"ITPR2, KCNMA1, ROCK1, ADORA2A, GNA13, PLCB3, CALML6, PLCB4, ADCY3, MAPK1, RAF1, MAP2K2, PRKACA, RHOA, PRKCA, CALM3, GNA11",0.00174066157630127,0,FALSE
+"H1703","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.27399,-1.01,0.415,17000,0.633,"RAB5B, ADCY9, CREB3L4, CREB3L1, DYNC1I1, AQP3, CREB5, ARHGDIB, CREB3L2, DCTN6",0.381951903287907,0.198596289982645,FALSE
+"H1703","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.33163,1.07,0.348,4409,0.61,"MAPK11, MAPK12, NFATC1, RAC1, HSPB1, MAPK1, AKT1, KRAS, PPP3R2, RAF1, NRAS, MAP2K2, PPP3CB, MAPK14, PRKCA, AKT3, PXN, NFAT5, PLCG2, BAD",0.458420756053419,0.214670164989233,FALSE
+"H1703","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.19574,-0.714,0.828,15082,0.903,"ATP6V0D2, CFTR, ATP6V1C2, ATP6V1G1, ATP6V1F, PDIA4, ATP6V0B, ATP6V0D1, PLCG1, ATP6V0A4, SEC61B, ADCY9, ATP6V1H, ATP6V1A, ATP6V1B2, TJP2",0.0819696632151199,0.0443122496864942,FALSE
+"H1703","Input","KEGG_VIRAL_MYOCARDITIS",0.31847,1.04,0.381,2602,0.652,"MYH2, RAC1, CXADR, DAG1, CD40, CYCS, MYH3, MYH9, EIF4G1, BID",0.419075024324381,0.18575240426808,FALSE
+"H1703","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31753,1.03,0.39,3422,0.657,"APC2, CCND2, PPP2R5A, NFATC1, RAC1, SMAD2, BTRC, WNT5B, MAPK9, PPP2CA, ROCK1, NKD2, RUVBL1, MAP3K7, APC, MAPK8, FBXW11, PLCB3, EP300, PPP2R5D, PLCB4, CACYBP, CSNK1A1, PPP3R2, LRP6, CSNK2B, CTBP1, VANGL1, SMAD4, DVL1, PPP3CB, DVL2, WNT6, PRKACA, PPP2R5E, NLK, RHOA, PRKCA",0.408935392973501,0.182434630440219,FALSE
+"HCC15","Input","KEGG_ABC_TRANSPORTERS",0.44979,1.41,0.0884,2887,0.382,"ABCG2, ABCC2, ABCG1, ABCB10, ABCC1, ABCC3, ABCB6, ABCA3, ABCD1, ABCC6, ABCA7",1.05354773498693,0.417936637088291,FALSE
+"HCC15","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.28805,0.9,0.59,5403,0.942,"KIT, CHUK, PPARD, AKT1, ARAF, IKBKG, MAP2K1, MTOR, RELA, LEF1, JUP, HRAS, AKT2, NRAS, PML, SOS1, PIK3R1, SOS2, PIM1, TCF7, TCF7L2",0.229147988357856,0.0259490972071227,FALSE
+"HCC15","Input","KEGG_ADHERENS_JUNCTION",-0.23557,-0.872,0.553,18295,1,"PTPRF, CTNNB1, CSNK2A1, SNAI2, WASF3, TGFBR1, ACTN1, NECTIN3, EP300, INSR, FYN",0.257274868695302,0,FALSE
+"HCC15","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.45547,1.44,0.068,4975,0.368,"PRKAB1, TNFRSF1B, POMC, CHUK, PRKAA2, SLC2A1, MAPK8, TRAF2, PPARA, ADIPOR1, PRKCQ, AKT1, G6PC2, IKBKG, NFKBIA, IRS1, TNFRSF1A, MTOR, RELA, CPT1A, LEPR, MAPK9, AKT2, NFKBIB, ADIPOR2, RXRA, PRKAA1, ACACB",1.16749108729376,0.434152181326482,FALSE
+"HCC15","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.21768,-0.812,0.712,17925,0.966,"IL4I1, GFPT2, ABAT, GLUL",0.147520006363144,0.0150228735845067,FALSE
+"HCC15","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.21922,0.694,0.89,1535,0.997,"PDPK1, INS, ATP1B1, SGK1, FXYD4",0.0506099933550872,0.00130484168834428,FALSE
+"HCC15","Input","KEGG_ALLOGRAFT_REJECTION",-0.21117,-0.786,0.774,4032,0.958,"FAS, CD40, IL10, GZMB, IL5, IFNG, FASLG, PRF1, CD40LG, IL2, CD28, CD80, IL4, CD86, TNF, IL12B, IL12A",0.111259039317107,0.0186344909214556,FALSE
+"HCC15","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.68384,2.18,0,1,0.119,"PLA2G1B",Inf,0.924453038607469,TRUE
+"HCC15","Input","KEGG_ALZHEIMERS_DISEASE",0.24113,0.767,0.824,4667,1,"NDUFS3, IDE, ITPR1, CASP9, CALM3, CHP1, APAF1, CALM1, CASP7, ATP5F1B, CAPN1, NDUFA9, NAE1, ATP2A2, NDUFV3, CASP8, COX5A, ITPR3, TNFRSF1A, NDUFB10, ATP5PO, NDUFA2, PPP3R1, COX7A2, NDUFB1, GAPDH, ATP5F1C, NDUFS1, PSEN2, BID, NDUFAB1, CAPN2, ATP5MC3, ATP5F1D, ADAM17, COX8A, FAS, ATF6, NCSTN, CALML6, ATP5MC2, CYC1, COX4I1, SDHD",0.0840727883028842,0,FALSE
+"HCC15","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.49543,1.55,0.0376,3522,0.336,"IARS2, EARS2, PSTK, FARSB, SEPSECS, RARS2, MTFMT, SARS2, YARS2",1.42481215507234,0.473660722610156,FALSE
+"HCC15","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.34327,1.09,0.333,5776,0.702,"GNPNAT1, UGDH, PGM3, GNPDA2, PMM2, GALK2, GPI, GFPT1, GALE, FPGT, HK3, NANS, GMDS, HK1, HEXB, PGM2, UXS1, PGM1, CMAS, HEXA",0.47755576649368,0.153662887870195,FALSE
+"HCC15","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.41376,1.32,0.124,3725,0.387,"TNFRSF1B, TOMM40, CASP9, CHP1, APAF1, SOD1, MAPK14, BCL2L1, MAP2K6, MAPK13, TNFRSF1A, MAP3K5, PPP3R1, BID",0.906578314837765,0.412289034981089,FALSE
+"HCC15","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.18466,0.583,0.981,6720,1,"NFYC, PSME2, B2M, CTSL, KLRC3, HSP90AA1, LGMN, HSP90AB1, KLRC2, PSME1, HSPA2, HSPA1A, HSPA8, PDIA3, CANX, IFI30, NFYA, HSPA5, HSPA4",0.0083309926200515,0,FALSE
+"HCC15","Input","KEGG_APOPTOSIS",0.43088,1.39,0.103,4034,0.382,"CHUK, IL3RA, CASP9, IRAK3, CHP1, APAF1, IRAK4, TRAF2, IRAK2, CASP7, ATM, AKT1, BCL2L1, CAPN1, IKBKG, NFKBIA, TNFRSF10A, MAP3K14, CASP8, CASP10, PRKACB, TNFRSF1A, RELA, PPP3R1, RIPK1, BID, CAPN2, AKT2, ENDOD1, FAS, PRKAR2A",0.987162775294828,0.417936637088291,FALSE
+"HCC15","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.53006,1.66,0.0233,1901,0.25,"PLA2G1B, LTA4H, CYP4F3, GGT5, PTGES, AKR1C3, PLA2G4A, GPX4, CBR1, GGT1",1.63264407897398,0.602059991327962,FALSE
+"HCC15","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31591,1.02,0.404,4880,0.81,"CPS1, AZIN2, SAT1, ALDH9A1, SRM, GLUD1, GAMT, ALDH3A2, ARG2, ALDH2, GOT2, MAOA, ODC1, AGMAT, CKB, OAT, ALDH18A1, ALDH7A1, ALDH4A1",0.393618634889395,0.0915149811213502,FALSE
+"HCC15","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.22285,-0.863,0.639,15744,1,"CACNA1C, ACTN2, CACNA2D2, LAMA2, CACNA2D3, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, DMD, CACNA2D1, CTNNB1, ACTN1, ITGB8, CACNB1, CACNB3",0.1944991418416,0,FALSE
+"HCC15","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.41692,1.32,0.119,3177,0.387,"UGDH, ALDH9A1, ALDH3A2, ALDH2",0.924453038607469,0.412289034981089,FALSE
+"HCC15","Input","KEGG_ASTHMA",-0.18282,-0.677,0.93,3491,0.942,"IL13, CD40, FCER1A, IL10, IL5, IL9, MS4A2, CD40LG, IL3, FCER1G, CCL11, IL4, PRG2, RNASE3, TNF, EPX",0.0315170514460649,0.0259490972071227,FALSE
+"HCC15","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.25945,0.817,0.745,14161,1,"FAS, CD40, IL10, GZMB, TPO, IL5, CTLA4, IFNA4, IFNA17, IFNA6, IFNA16, FASLG, IFNA10, IFNA2, IFNA7, PRF1, IFNA14, CD40LG, IL2, CD28, TSHB, IFNA1, CD80, IFNA13, IL4, CGA, IFNA21, TG, IFNA8, IFNA5, TSHR, CD86",0.127843727251707,0,FALSE
+"HCC15","Input","KEGG_AXON_GUIDANCE",-0.33687,-1.26,0.141,15481,1,"EPHA7, FES, UNC5A, EPHA6, PAK3, SEMA3G, EFNA4, ROBO2, CXCL12, DPYSL5, EPHA3, EPHA4, EPHA5, DPYSL2, PAK2, EPHB2, EPHA1, SEMA6D, NTNG1, EPHB1, SRGAP1, PLXNC1, CXCR4, SEMA3D, SEMA3E, NFATC2, SEMA5A, SEMA6C, SLIT2, SEMA6A, SEMA4A, NTN1, EFNB3, PLXNB2, EFNB1, PLXNA2, UNC5B, EFNA3, PLXNB3, SEMA3A, SRGAP3, LIMK2, NFATC1, SEMA7A, L1CAM, ROBO1, FYN, ROBO3, PLXNB1, GSK3B",0.85078088734462,0,FALSE
+"HCC15","Input","KEGG_BASAL_CELL_CARCINOMA",-0.18834,-0.719,0.869,15472,0.912,"WNT2B, WNT7A, PTCH2, APC2, HHIP, GLI1, DVL2, WNT10A, WNT10B, WNT5A, DVL3, FZD8, WNT7B, CTNNB1, GSK3B",0.0609802235513335,0.0400051616715838,FALSE
+"HCC15","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.46988,1.49,0.0561,2124,0.37,"TAF1L, GTF2H1, GTF2A1, TAF12, TAF9, TBPL1, GTF2H3, TBP, GTF2IRD1",1.25103713874384,0.431798275933005,FALSE
+"HCC15","Input","KEGG_BASE_EXCISION_REPAIR",0.35265,1.12,0.285,6586,0.675,"POLE2, TDG, POLE3, PARP4, POLD3, OGG1, LIG1, FEN1, POLD1, UNG, NEIL1, POLL, POLE4, LIG3, NEIL3, APEX2, NTHL1",0.54515513999149,0.170696227168975,FALSE
+"HCC15","Input","KEGG_BETA_ALANINE_METABOLISM",0.3441,1.09,0.322,4736,0.702,"HADHA, ALDH9A1, HIBCH, SRM, ALDH3A2, ALDH2, ECHS1, GAD1, ALDH7A1",0.492144128304169,0.153662887870195,FALSE
+"HCC15","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29902,0.931,0.538,4664,0.922,"HADHA, HACD1, ACOT7, ACOX1, PECR, YOD1, FADS1",0.269217724333611,0.0352690789463706,FALSE
+"HCC15","Input","KEGG_BLADDER_CANCER",-0.30586,-1.08,0.356,15843,0.909,"RAF1, MMP9, VEGFA, ERBB2, FGFR3, CDKN1A, DAPK2, MMP1, MAP2K2, VEGFB, PGF, MMP2, CDKN2A, DAPK3, DAPK1, RB1",0.448550002027125,0.0414361167780325,FALSE
+"HCC15","Input","KEGG_BUTANOATE_METABOLISM",0.35252,1.11,0.296,4736,0.681,"HADHA, ALDH9A1, ALDH3A2, ACAT1, AACS, ALDH2, ACADS, ALDH5A1, L2HGDH, ECHS1, GAD1, ACSM4, ALDH7A1",0.528708288941061,0.166852888087215,FALSE
+"HCC15","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.2376,0.751,0.824,4450,1,"NFAT5, CHUK, SYK, IFITM1, CHP1, LYN, AKT1, NFATC3, IKBKG, NFKBIA, MAP2K1, RELA, CD22, PPP3R1, HRAS, AKT2, NRAS, PTPN6, NFKBIB, SOS1",0.0840727883028842,0,FALSE
+"HCC15","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.16516,0.514,0.997,3531,1,"NTSR1, ITPR1, GNAL, CALM3, VDAC2, CHP1, ADCY9, ADCY7, CALM1, GNA15, P2RX5, MYLK2, PLCD4, PHKB, ATP2A2, PHKA1, PRKACB, ITPR3, PTK2B, PPP3R1, VDAC1, ITPKA, ITPKB",0.00130484168834428,0,FALSE
+"HCC15","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.36529,-1.33,0.139,14113,1,"COX7B2, ATP1B2, MYL2, TPM4, ATP1A2, UQCR11, FXYD2, TNNC1, UQCRHL, COX8C, CACNG7, CACNA1C, TNNT2, CACNA2D2, CACNA2D3, RYR2, CACNB4, COX6B2, UQCRC1, CACNA1D, CACNG4, COX5B, UQCR10, COX6C, SLC8A1, TPM1, ATP1A3, COX7C, UQCRB, CACNA2D1, TPM2, CACNB1, CACNB3",0.856985199745905,0,FALSE
+"HCC15","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.25305,-0.95,0.45,15177,1,"VCAM1, CDH4, CLDN10, ITGA9, CDH3, CLDN16, NLGN4X, CNTNAP2, CLDN11, JAM2, NCAM2, NLGN3, CNTN1, ITGAM, NRXN2, JAM3, CD8A, CLDN22, SELL, PDCD1LG2, CADM1, NCAM1, NRXN3, NFASC, NLGN1, NECTIN1, ITGA4, NRCAM, ICOSLG, SDC2, PTPRF, NEO1, NECTIN3, ITGB8, L1CAM, SDC1",0.346787486224656,0,FALSE
+"HCC15","Input","KEGG_CELL_CYCLE",0.455,1.42,0.0814,5635,0.389,"PTTG1, CCND3, CDC25C, CDC23, ORC1, TTK, PLK1, BUB3, ANAPC4, SMAD2, BUB1, CCNB1, ORC4, ORC3, PTTG2, CCNB2, MCM6, ANAPC5, PRKDC, CHEK1, SKP1, CDC6, ATM, E2F3, ABL1, MCM3, CDC7, SMC3, YWHAQ, CDK1, BUB1B, MCM4, HDAC1, CDC45, CDC20, SMC1A, ORC2, YWHAG, E2F2, CDC25B, ANAPC7, ESPL1, ORC6, E2F4, SFN, CDC27, CCNE2, CDK2, TGFB1, CDC14A, DBF4, CDC14B, CDK6, YWHAZ, CCNH, CDKN2C, CUL1, CCNA2, ANAPC2, RBL1, MCM7, WEE2, MAD2L2, CDK7, CDKN1C, ORC5, HDAC2, STAG2, CDKN1B, WEE1, RAD21",1.0893755951108,0.410050398674292,FALSE
+"HCC15","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.20526,0.648,0.935,5017,1,"CCL5, CHUK, SHC1, ROCK2, SHC3, GNG11, GNB5, ADCY9, ADCY7, WASL, ARRB1, GSK3A, LYN, AKT1, IKBKG, NFKBIA, CCL28, MAP2K1, CDC42, CCL22, PRKACB, PTK2B, CXCL5, CCL2, RELA, HRAS, GNAI1, PXN, CXCL8, GNB1, GRK5, AKT2, GNAI3, NRAS, NFKBIB, SOS1, CCL14, PIK3R1, STAT2, GNG10, SOS2, RAP1B",0.0291883891274822,0,FALSE
+"HCC15","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.26224,0.828,0.719,5826,1,"CHUK, SHC1, SHC3, E2F3, ABL1, AKT1, ARAF, HDAC1, BCL2L1, CTBP2, IKBKG, NFKBIA, MAP2K1, CBL, E2F2, RELA, HRAS, AKT2, NRAS, TGFB1, TGFBR2, SOS1, CDK6, PIK3R1, SOS2, HDAC2, CRK, CDKN1B, MAPK3, TGFB2",0.143271109617117,0,FALSE
+"HCC15","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.33336,1.06,0.369,6488,0.742,"NPAS2, CSNK1E, ARNTL, PER2, NR1D1, PER1, CRY2",0.43297363384094,0.129596094720973,FALSE
+"HCC15","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2438,0.778,0.791,1292,1,"PC, DLAT, IDH3A",0.101823516502323,0,FALSE
+"HCC15","Input","KEGG_COLORECTAL_CANCER",0.22631,0.706,0.897,5403,0.998,"CASP9, SMAD2, AXIN2, MAPK8, MSH2, AKT1, ARAF, APC, MAP2K1, MSH3, MSH6, APPL1, LEF1, MAPK9, AKT2, TGFB1, TGFBR2, PIK3R1, BIRC5, TCF7, TCF7L2",0.0472075569559079,0.000869458712628891,FALSE
+"HCC15","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.3153,0.994,0.453,3883,0.83,"THBD, SERPIND1, C3AR1, CFH, CD46, TFPI, PLAUR, MASP2, F13A1, C5, PLAU, SERPINC1, CD59, CFD",0.343901797987168,0.0809219076239261,FALSE
+"HCC15","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.46262,1.45,0.0802,3195,0.364,"BHMT, ADI1, MAT2A, MAT2B, TRDMT1, LDHA, SRM, AHCYL2, AHCYL1, APIP, GOT2",1.09582563171584,0.438898616350944,FALSE
+"HCC15","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.17804,0.563,0.987,672,1,"TNFSF15, TNFRSF1B, CSF2RA, CCL5, EGF, TNFSF8, KIT, FLT4, CNTF, IL3RA, IFNGR1",0.00568284733036327,0,FALSE
+"HCC15","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.34791,1.1,0.313,4369,0.697,"CCL5, CHUK, TBK1, IKBKG, POLR3K, NFKBIA, POLR3A, RELA, ZBP1, RIPK1, RIPK3, ADAR, POLR3B, POLR1C, NFKBIB, IL18",0.504455662453552,0.156767221901991,FALSE
+"HCC15","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22816,-0.853,0.669,14773,1,"SGCD, TNF, TNNC1, DES, CACNG7, ITGA9, ADCY1, CACNA1C, TNNT2, CACNA2D2, LAMA2, CACNA2D3, ADCY5, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, TPM1, DMD, CACNA2D1, ITGB8, GNAS, TPM2, CACNB1, CACNB3",0.174573882232177,0,FALSE
+"HCC15","Input","KEGG_DNA_REPLICATION",0.60201,1.89,0.00358,4243,0.23,"DNA2, MCM6, POLE2, RFC5, POLE3, MCM3, MCM4, POLA1, RFC2, PRIM1, POLA2, PRIM2, POLD3, RFC1, RPA2, RNASEH1, RPA1, LIG1, FEN1, POLD1",2.44611697335613,0.638272163982407,TRUE
+"HCC15","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.15222,-0.592,0.971,16707,0.979,"ETV7, FMN2, NOTCH4, CPEB1",0.0127807700919951,0.00921730819686218,FALSE
+"HCC15","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.15554,0.49,0.999,3621,0.997,"ALDH3A1, ALDH3B1, GSTM2, GSTM4, GSTM3, CYP3A5, MAOA, MGST1",0.000434511774017692,0.00130484168834428,FALSE
+"HCC15","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.30544,-1.14,0.28,17562,0.962,"ITPA, XDH, UMPS, GMPS, NAT1, IMPDH2, UCKL1",0.552841968657781,0.0168249279621871,FALSE
+"HCC15","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.2005,-0.758,0.844,15298,0.954,"COL11A1, LAMC1, ITGA9, RELN, COL5A3, COL6A1, LAMA2, COL6A3, THBS2, ITGA7, CHAD, COL1A2, COL4A2, FN1, THBS4, ITGA4, LAMA4, ITGB3, COL6A2, SV2A, SDC2, THBS3, LAMB1, ITGB8, SDC1, CD47",0.073657553374345,0.0204516252959049,FALSE
+"HCC15","Input","KEGG_ENDOCYTOSIS",0.27333,0.87,0.645,4500,0.968,"DNM3, EGF, STAM, AP2S1, KIT, IQSEC2, RAB11FIP2, RAB11A, USP8, ARRB1, STAM2, SH3KBP1, SMAP1, AP2A2, VTA1, SMURF2, SMAP2, NEDD4, TSG101, GIT2, ASAP1, CBL, PIKFYVE, EEA1, CDC42, STAMBP, RUFY1, ACAP3, CHMP4C, VPS4A, ARAP2, ASAP2, CHMP4A, SH3GLB2, LDLRAP1, VPS37A, WWP1, DNAJC6, SH3GLB1, HRAS, CLTCL1, GRK5, CHMP1B, DNM1L, AP2B1, DNM1, ARFGAP2, RAB31, IGF1R, CLTB, RAB11FIP3",0.190440285364732,0.0141246426916063,FALSE
+"HCC15","Input","KEGG_ENDOMETRIAL_CANCER",0.29474,0.93,0.543,5551,0.914,"EGF, PDPK1, CASP9, AXIN2, AKT1, CTNNA1, ARAF, APC, MAP2K1, LEF1, HRAS, AKT2, ILK, NRAS, SOS1, PIK3R1, ELK1, SOS2, TCF7, PTEN, TCF7L2, CDH1",0.265200170411153,0.0390538042661686,FALSE
+"HCC15","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.44259,1.4,0.0749,4447,0.375,"CCL5, ATP6V0A4, CHUK, MAPK8, TJP1, LYN, MAPK14, ATP6V0E1, ATP6V1E1, ATP6V1C1, ATP6V0A1, ATP6V1H, IKBKG, ATP6V0B, NFKBIA, TCIRG1, ATP6V0D1, CDC42, MAP3K14, ATP6V0C, MAPK13, MAP2K4, RELA, ATP6V1A, ATP6V0E2, CXCL8, MAPK9, ADAM17, HBEGF, ATP6V1G1, ATP6V0A2",1.12551818230053,0.425968732272281,FALSE
+"HCC15","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.19345,-0.742,0.875,17973,0.901,"SHC2, MAPK10, EIF4EBP1, PIK3CD, MAP2K7, AKT3, PLCG1, PIK3R2, JUN, GSK3B, GAB1",0.0579919469776868,0.045275209020937,FALSE
+"HCC15","Input","KEGG_ETHER_LIPID_METABOLISM",0.60914,1.94,0.00359,2363,0.218,"PLA2G1B, PAFAH2, PAFAH1B2, PAFAH1B3, PLA2G4A, PLPP3, CHPT1",2.44490555142168,0.661543506395395,TRUE
+"HCC15","Input","KEGG_FATTY_ACID_METABOLISM",0.35784,1.12,0.279,3417,0.675,"HADHA, ECI1, HADHB, ACADSB, ALDH9A1, ALDH3A2, ACOX1, ACAT1, ALDH2, CPT1A, ACADS",0.554395796726402,0.170696227168975,FALSE
+"HCC15","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.34356,1.07,0.348,3845,0.725,"PLA2G1B, SYK, PDPK1, MAPK8, LYN, MAPK14, AKT1, PLA2G4A, PRKCE, MAP2K1, MAP2K6, MAPK13, MAP2K4, IL13, HRAS, MAPK9, AKT2",0.458420756053419,0.139661993429006,FALSE
+"HCC15","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.26261,0.818,0.727,4238,1,"DNM3, SYK, CFL2, ARPC2, WASL, ARPC5L, LYN, AKT1, PLA2G4A, WASF2, PLPP3, PRKCE, ARPC3, ASAP1, MAP2K1, PIKFYVE, CDC42, ASAP2, CFL1, MYO10, DNM1L, AKT2, LIMK1, DNM1, ARPC4",0.138465589140962,0,FALSE
+"HCC15","Input","KEGG_FOCAL_ADHESION",0.18106,0.56,0.986,5638,1,"COL4A6, ITGA10, EGF, CCND3, FLT4, PDPK1, FLNB, SHC1, ROCK2, ITGA1, SHC3, COL3A1, MAPK8, DIAPH1, COL5A2, MYLK2, AKT1, ITGB5, MAP2K1, PARVA, CDC42, ARHGAP35, ITGB7, PPP1CC, COL4A4, ITGB4, ACTN4, ITGA2, HRAS, ARHGAP5, LAMB3, PXN, CAPN2, MAPK9, AKT2, ILK, PPP1CA, IGF1R, PPP1CB, SOS1, XIAP, ITGA6, ITGB1, PIK3R1, ELK1, SOS2, RAP1B, PTEN, BIRC2, LAMA1, RAPGEF1, PAK1, PRKCA, ITGA11, CRK, VCL, BIRC3, LAMB2, BCAR1",0.0061230850587888,0,FALSE
+"HCC15","Input","KEGG_FOLATE_BIOSYNTHESIS",0.49637,1.57,0.0406,4914,0.323,"PTS, SPR, DHFR, GCH1, GGH, FPGS",1.39147396642281,0.490797477668897,FALSE
+"HCC15","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.27561,0.882,0.63,6028,0.958,"PFKP, PMM2, MTMR2, ALDOA, FPGT, SORD, HK3, GMDS, HK1, KHK, MTMR7, MTMR6, PHPT1",0.200659450546418,0.0186344909214556,FALSE
+"HCC15","Input","KEGG_GALACTOSE_METABOLISM",0.35175,1.12,0.282,3599,0.675,"GLA, PFKP, B4GALT1, G6PC2, GALK2, GALE, HK3",0.549750891680639,0.170696227168975,FALSE
+"HCC15","Input","KEGG_GAP_JUNCTION",0.23255,0.727,0.859,5227,1,"TUBAL3, EGF, ITPR1, ADCY9, ADCY7, MAP3K2, TJP1, CDK1, LPAR1, MAP2K1, PRKACB, ITPR3, TUBB3, HRAS, GNAI1, GNAI3, NRAS, SOS1, TUBB2A, SOS2, TUBA1C, TUBB, TUBA4A, TUBA1B",0.0660068361687577,0,FALSE
+"HCC15","Input","KEGG_GLIOMA",0.23961,0.765,0.812,4999,1,"EGF, SHC1, SHC3, CALM3, CALM1, E2F3, AKT1, ARAF, TGFA, MAP2K1, E2F2, MTOR, HRAS, AKT2, NRAS, IGF1R, SOS1, CALML6, CDK6, PIK3R1, CALM2, SOS2",0.0904439707588247,0,FALSE
+"HCC15","Input","KEGG_GLUTATHIONE_METABOLISM",0.5227,1.64,0.0332,4965,0.259,"GCLC, PGD, GSR, GCLM, G6PD, GGT5, RRM1, TXNDC12, GPX4, SRM, GGT1, GSTM2, GSTM4, GSS, GSTM3, RRM2, ODC1, GPX7, MGST1, GPX3, MGST2, GSTO1, GSTK1, RRM2B",1.47886191629596,0.586700235918748,FALSE
+"HCC15","Input","KEGG_GLYCEROLIPID_METABOLISM",0.35194,1.11,0.291,3355,0.681,"GLA, AGPAT3, DGKG, AKR1A1, ALDH9A1, PLPP3, GPAT3, ALDH3A2, DGKD, MBOAT1, ALDH2, TKFC",0.536107011014093,0.166852888087215,FALSE
+"HCC15","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.43918,1.38,0.103,2870,0.368,"PLA2G1B, AGPAT3, PTDSS2, DGKG, PTDSS1, GPD2, LYPLA2, MBOAT7, PLA2G4A, ETNK1, PLPP3, GPAT3, LYPLA1, CHPT1, DGKD, GNPAT, MBOAT1",0.987162775294828,0.434152181326482,FALSE
+"HCC15","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.25618,0.805,0.765,3612,1,"BHMT, DMGDH, GAMT, SHMT1, MAOA, DLD",0.116338564846382,0,FALSE
+"HCC15","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.39976,1.25,0.153,4179,0.484,"ALDH3A1, ENO3, ENO1, PFKP, DLAT, AKR1A1, ALDH3B1, ALDH9A1, G6PC2, LDHA, ALDH3A2, GPI, PGAM1, GALM, PKM, ALDOA, ALDH2, GAPDH, HK3, DLD, ACSS2, LDHAL6B",0.815308569182401,0.315154638355588,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.29443,0.924,0.565,4809,0.91,"CHST15, CSGALNACT1, B3GAT3, DSE, CSGALNACT2, B3GAT2, CHST7",0.247951552180562,0.0409586076789064,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.27858,-1.02,0.385,15306,0.969,"HS3ST5, NDST3, B3GAT1, HS3ST3B1, B4GALT7, HS3ST1, HS3ST3A1, NDST1, XYLT1, HS6ST2, XYLT2, EXT1",0.414539270491499,0.0136762229492347,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.45621,-1.72,0.0244,17191,0.54,"B3GNT7, CHST2, FUT8, ST3GAL1, B3GNT2, B4GALT4, B4GALT2",1.61261017366127,0.267606240177031,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.44304,1.37,0.0947,6089,0.348,"HYAL1, GUSB, GALNS, GNS, ARSB, HGSNAT, NAGLU, HEXB, SGSH, HEXA, HYAL3",1.02365002099673,0.458420756053419,FALSE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.27762,-0.998,0.401,14743,0.981,"GLB1, B3GALT4, ST6GALNAC6, ST8SIA1, ST6GALNAC5, ST3GAL1, SLC33A1",0.396855627379818,0.0083309926200515,FALSE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3276,1.02,0.392,71,0.81,"GLA",0.406713932979543,0.0915149811213502,FALSE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.32609,-1.23,0.192,16056,0.996,"B3GALT1, ABO, B3GALT5, FUT3, ST8SIA1, B3GNT2, ST3GAL6, B4GALT4, B4GALT2",0.71669877129645,0.00174066157630127,FALSE
+"HCC15","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.3429,1.07,0.335,2640,0.725,"PIGN, PIGB, DPM2, PGAP1, PIGP, PIGU",0.474955192963155,0.139661993429006,FALSE
+"HCC15","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.27868,0.869,0.642,2851,0.96,"PGP, CS",0.192464971931147,0.0177287669604316,FALSE
+"HCC15","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.33809,1.07,0.347,3080,0.725,"PLA2G1B, ITPR1, CALM3, ADCY9, ADCY7, CALM1, MAPK8, MAP3K2, MAPK14, PLA2G4A, MAP2K1, CDC42, MAP2K6, PRKACB, MAPK13, ITPR3, PTK2B, MAP2K4",0.459670525209126,0.139661993429006,FALSE
+"HCC15","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.23138,-0.852,0.658,9778,0.977,"IFNG, FASLG, PRF1, KIR2DL1, KIR3DL2, IL2, KLRD1, CD28, KIR3DL1, KIR2DL3, CD80, KLRC1, CD86, IL6, TNF, IL1B",0.181774106386044,0.0101054362812269,FALSE
+"HCC15","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.19735,0.618,0.969,2636,1,"BTRC, CSNK1E, BMP4, CSNK1G1, GLI2, CSNK1G2, WNT3, PRKACB",0.0136762229492347,0,FALSE
+"HCC15","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.2343,0.739,0.838,675,1,"CD14, CSF2RA, KIT, IL3RA, ITGA1",0.0767559813697235,0,FALSE
+"HCC15","Input","KEGG_HISTIDINE_METABOLISM",0.4684,1.47,0.0548,5111,0.343,"AMDHD1, ALDH3A1, TRMT11, ALDH3B1, ALDH9A1, HAL, ALDH3A2, METTL2B, ALDH2, MAOA, BUD23, ALDH7A1, HDC, LCMT2, LCMT1",1.26121944151563,0.464705879957229,FALSE
+"HCC15","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.43939,1.38,0.0858,5951,0.368,"XRCC3, RAD51, BLM, MRE11, RAD54B, POLD3, RPA2, MUS81, RAD54L, RPA1, NBN, XRCC2, POLD1, RAD50, RAD51D, RPA3, RPA4, TOP3A, EME1, RAD52",1.06651271215129,0.434152181326482,FALSE
+"HCC15","Input","KEGG_HUNTINGTONS_DISEASE",0.26277,0.816,0.735,4667,1,"NDUFS3, RCOR1, AP2S1, POLR2J2, ITPR1, BDNF, CASP9, VDAC2, APAF1, SOD1, TGM2, ATP5F1B, AP2A2, POLR2E, TBPL1, HDAC1, DCTN4, TBP, SP1, NDUFA9, POLR2D, POLR2A, NDUFV3, CASP8, POLR2C, CREB3L2, COX5A, NDUFB10, ATP5PO, POLR2L, NDUFA2, VDAC1, COX7A2, NDUFB1, ATP5F1C, CLTCL1, NDUFS1, NDUFAB1, POLR2G, ATP5MC3, DNAH1, TFAM, ATP5F1D, COX8A, SIN3A, AP2B1, CLTB, ATP5MC2, CYC1, COX4I1, SDHD",0.133712660915805,0,FALSE
+"HCC15","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.21991,-0.827,0.692,14165,1,"MYL2, SGCG, TPM4, PRKAG1, IGF1, IL6, SGCD, TNF, TNNC1, DES, CACNG7, PRKAG2, ITGA9, CACNA1C, ACE, TNNT2, CACNA2D2, LAMA2, CACNA2D3, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, TPM1, DMD, CACNA2D1, ITGB8, TPM2, CACNB1, CACNB3",0.159893905543242,0,FALSE
+"HCC15","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.23102,-0.862,0.619,17903,1,"PIP5K1C, PIK3C3, PLCE1, PIK3CD, ALDH6A1, INPP5J, PLCG1, PLCB1, INPP4B",0.208309350979882,0,FALSE
+"HCC15","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.2936,0.925,0.571,4999,0.917,"PRKAB1, PDE3A, PPP1R3C, PRKAA2, PDPK1, MKNK2, SHC1, INS, SHC3, CALM3, CALM1, MAPK8, MKNK1, AKT1, ARAF, G6PC2, PHKB, MAP2K1, CBL, PHKA1, PRKACB, PPP1CC, IRS1, MTOR, SORBS1, ACACA, HRAS, HK3, MAPK9, AKT2, PRKAR2A, SOCS4, PPP1CA, NRAS, PPP1CB, SOS1, PHKG2, CALML6, HK1, TSC1, PIK3R1, PRKAA1, CALM2, ELK1, ACACB, SOS2",0.243363891754152,0.0376306643299789,FALSE
+"HCC15","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.19757,-0.752,0.775,17241,0.937,"CXCR4, ITGA4, CCR10, ICOSLG, IL15",0.11069829749369,0.0282604091122217,FALSE
+"HCC15","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.17092,0.536,0.987,5338,1,"CSF2RA, CCND3, STAM, CNTF, IL3RA, IFNGR1, STAM2, AKT1, SPRED2, BCL2L1, SPRED1, IL10RB, CBL, IL22RA1, SPRY4, PIAS1, IFNLR1, LEPR, IL13, AKT2, SOCS4, PTPN6, IL13RA1, IFNAR1, SPRY1, SOS1, PIK3R1, STAT2, OSMR, SOS2, PIM1, MPL, IFNAR2, IL4R, IL20RA",0.00568284733036327,0,FALSE
+"HCC15","Input","KEGG_LEISHMANIA_INFECTION",0.18164,0.566,0.984,6037,1,"IFNGR1, IRAK4, MAPK14, NFKBIA, MAPK13, PTGS2, RELA, MAP3K7, TGFB1, PTPN6, NFKBIB, ITGB2, ITGB1, ELK1, TAB2, TRAF6, CYBA, MAPK3, TGFB2, IL10",0.00700490156865849,0,FALSE
+"HCC15","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.20078,0.631,0.932,5638,1,"CLDN2, TXK, ROCK2, RASSF5, MAPK14, CTNNA1, SIPA1, CD99, CDC42, ARHGAP35, MAPK13, PTK2B, CLDN4, ACTN4, ARHGAP5, CTNND1, GNAI1, PXN, CLDN23, MSN, GNAI3, NOX1, ITGB2, ITGB1, PIK3R1, CLDN3, ESAM, CLDN20, RAP1B, EZR, PRKCA, ICAM1, CYBA, VCL, BCAR1",0.0305840876460186,0,FALSE
+"HCC15","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.57214,1.75,0.0173,4736,0.353,"HADHA, ALDH9A1, ALDH3A2, ALDH2, ECHS1, YOD1, ALDH7A1",1.7619538968712,0.452225294612177,FALSE
+"HCC15","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.59268,1.84,0.0105,1,0.243,"PLA2G1B",1.97881070093006,0.614393726401688,TRUE
+"HCC15","Input","KEGG_LONG_TERM_DEPRESSION",0.41246,1.28,0.152,1786,0.443,"PLA2G1B, PPP2R1B, ITPR1, GNA13, PPP2R1A, LYN, ARAF, PLA2G4A",0.818156412055227,0.35359627377693,FALSE
+"HCC15","Input","KEGG_LONG_TERM_POTENTIATION",0.22951,0.722,0.846,6597,1,"ITPR1, CALM3, CHP1, CALM1, ARAF, MAP2K1, PRKACB, PPP1CC, ITPR3, PPP3R1, HRAS, RPS6KA1, PPP1CA, NRAS, PPP1CB, CALML6, CALM2, RAP1B, PPP3CB, PRKCA, MAPK3, RAP1A, PPP1R12A, RPS6KA3, PLCB3, PPP3CC, GRIN1",0.0726296369609765,0,FALSE
+"HCC15","Input","KEGG_LYSINE_DEGRADATION",0.43876,1.38,0.0995,4736,0.368,"HADHA, KMT5A, SUV39H1, AASDHPPT, ALDH9A1, EHMT1, ALDH3A2, SETD1B, ACAT1, ALDH2, SETD1A, TMLHE, PLOD1, ECHS1, SUV39H2, SETD7, EHMT2, ASH1L, NSD1, ALDH7A1",1.00217691925427,0.434152181326482,FALSE
+"HCC15","Input","KEGG_LYSOSOME",0.40725,1.27,0.153,5776,0.453,"GLA, HYAL1, ATP6V0A4, AP1S3, AP4E1, AP3M1, AP3B1, AP4B1, FUCA1, ARSG, SLC11A2, CLN3, ACP2, CD164, SLC17A5, GUSB, ATP6V0A1, SORT1, SLC11A1, ATP6V1H, ATP6V0B, GALNS, TCIRG1, ATP6V0D1, AP1G1, ATP6V0C, MFSD8, GNS, NAGPA, ARSB, CTSL, CTSF, CLTCL1, HGSNAT, AP3S1, GM2A, GNPTAB, LGMN, GNPTG, ATP6V0A2, CLTB, PPT1, NAGLU, PPT2, SMPD1, HEXB, ABCA2, PLA2G15, IGF2R, CTSV, TPP1, SGSH, GBA, M6PR, HEXA",0.815308569182401,0.343901797987168,FALSE
+"HCC15","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.23077,0.719,0.87,3405,1,"PLA2G1B, FGF9, FGF19, CD14, EGF, PPP5C, CHUK, FLNB, BDNF, RPS6KA5, MKNK2, CHP1, MEF2C, MAPK8, MAP3K2, MKNK1, TRAF2, ARRB1, DUSP4, MAPK14, AKT1, PLA2G4A, MAP4K3, MAP3K8, IKBKG, NR4A1, MAP2K1, CDC42, MAP3K14, MAP2K6, PRKACB, MAPK13, ATF2, TAOK2, MAPKAPK5, TNFRSF1A, MAP2K4, STK3, CDC25B, RELA, MAP3K5, PPP3R1",0.0604807473813815,0,FALSE
+"HCC15","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.24869,-0.943,0.471,13942,0.983,"ONECUT1, HNF4A, HNF1A, BHLHA15, FOXA2, PDX1, GCK, HNF1B, NR5A2, HNF4G",0.326979092871104,0.00744648216786438,FALSE
+"HCC15","Input","KEGG_MELANOGENESIS",0.16347,0.521,0.995,5572,1,"POMC, KIT, CALM3, ADCY9, ADCY7, CALM1, FZD3, MAP2K1, WNT3, PRKACB, CREB3L2, LEF1, HRAS, DVL1, GNAI1, GNAI3, MC1R, NRAS, CALML6, FZD9, FZD6, EDN1, CALM2, TCF7, TCF7L2, PRKCA, FZD1",0.00217691925427455,0,FALSE
+"HCC15","Input","KEGG_MELANOMA",-0.24001,-0.885,0.634,16661,1,"FGF11, PIK3CA, CDKN1A, FGF2, FGF22, FGF1, PDGFRB, MAP2K2, PDGFD, FGF13, FGF12, MITF, PIK3CD, CDKN2A, AKT3, PDGFC, PIK3R2, RB1",0.197910742118267,0,FALSE
+"HCC15","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.36037,1.14,0.245,3651,0.666,"ALDH3A1, CYP2S1, EPHX1, AKR1C2, AKR1C1, AKR1C3, ALDH3B1, GSTM2, GSTM4, GSTM3, CYP3A5, MGST1, CYP1B1",0.610833915635468,0.176525770829699,FALSE
+"HCC15","Input","KEGG_MISMATCH_REPAIR",0.55307,1.73,0.0224,5582,0.299,"MSH2, RFC5, RFC2, MSH3, POLD3, RFC1, MSH6, RPA2, RPA1, LIG1, POLD1, EXO1, RPA3, RPA4",1.64975198166584,0.52432881167557,FALSE
+"HCC15","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.29786,0.933,0.54,1866,0.927,"MLST8, PRKAA2, PDPK1, CAB39, INS, AKT1, EIF4B, ULK3, RICTOR",0.267606240177031,0.0329202658555029,FALSE
+"HCC15","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.32687,1.01,0.417,4493,0.806,"RAET1G, RAET1E, SH2D1B, NFAT5, ULBP3, SYK, SHC1, IFNGR1, SHC3, CHP1, ARAF, ICAM2, NFATC3, MAP2K1, TNFRSF10A, MICB, PTK2B, MICA, KLRC3, PPP3R1, HRAS, BID, FAS, KLRC2, NRAS, PTPN6, IFNAR1, SOS1, ITGB2",0.379863945026242,0.0936649581949093,FALSE
+"HCC15","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.2196,-0.823,0.686,11147,0.974,"OPRK1, GRIN2A, HTR2B, NPY2R, GABRG1, TAAR1, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CHRND, GABRA1, PRL, P2RY10, HTR4, GH1, GRM1, P2RX3, HTR1F, TSHB, ADRA1A, HCRTR2, GABRA4, NMUR1, GPR50, F2, CHRNG, RXFP1, MC5R, DRD5, MCHR1, GCGR, CHRM1, MC3R, HTR6, AVPR1A, CYSLTR1, GABRB2, GRIN3A, CALCR, GRM7, P2RX4, AVPR1B, TACR3, HRH3, ADCYAP1R1, HTR2A, GABRR2, GRIA1, CGA, NPY5R, GRM5, NMUR2, THRB, P2RY8, UTS2R, LHB, NPFFR1, CHRNB1, GRM3, NPY4R, HTR1B, GHSR, CHRNA4, PRSS2, P2RY13, GHRHR, GABRR1, GRIK3, CHRM2, F2RL3, GRIA4, CHRNA1, P2RX2, P2RX1, GABRD, PTGER3, GABRA5, PRSS1, MC4R, MCHR2, GRIA2, TACR2, CHRNA3, ADRA2C, GABRB1, P2RX6, GABRG3, TRHR, SCTR, CRHR1, CHRNB2, TSHR, PLG, GRID2, OPRD1, GRIA3, DRD1, CTSG, GRM2, GRM4, LPAR4, GRIN2C, TBXA2R, GABRA2, GABRG2, ADRA2A, GABRP, PTGIR, PTGER4, ADRA1D, NPBWR1, GRIN2B, CHRNA9, AGTR1, SSTR2, GRIN2D, CHRNB4, GRIK5, P2RY14, MLNR, MTNR1A, PTH2R, ADRA2B, GRM8, EDNRB, SSTR1, NPFFR2, NPY1R, CNR1, DRD2, PTAFR, DRD4, CHRNE, PTGER1, S1PR3, HTR2C, GALR3, GRID1, PRLR, NMBR, GABBR2, GRIK4, GPR83, GRPR, AVPR2, S1PR5, GPR35, GABRQ, PTGFR, PTGER2, PTH1R, OXTR, VIPR1, GHR, LPAR2, P2RX7, CHRM4, PRSS3, P2RY1, LPAR3, HRH4, GRIK2, BDKRB1, ADORA1, ADRA1B, BDKRB2, GABRA3, OPRL1, ADORA2A, ADORA2B, GLRB, S1PR2, GABBR1",0.163675884293248,0.0114410431213845,FALSE
+"HCC15","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.23263,0.738,0.858,5017,1,"PDPK1, BDNF, RPS6KA5, SHC1, SHC3, CALM3, IRAK3, IRAK4, CALM1, MAPK8, IRAK2, ABL1, MAPK14, PRDM4, AKT1, YWHAQ, SORT1, NFKBIA, KIDINS220, MAP2K1, CDC42, YWHAG, MAPK13, IRS1, RELA, MAP3K5, HRAS, MAPK9, AKT2, RPS6KA1, NRAS, NFKBIB, SOS1, CALML6, YWHAZ, ZNF274, PIK3R1, CALM2, SOS2, RAP1B",0.0665127121512946,0,FALSE
+"HCC15","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.46767,1.48,0.0538,3025,0.354,"NMNAT1, NAMPT, NNMT, NADK, NT5C2, NT5M, NT5E, NMRK1, NNT",1.26921772433361,0.450996737974212,FALSE
+"HCC15","Input","KEGG_NITROGEN_METABOLISM",0.28502,0.909,0.576,1956,0.929,"CA12, CPS1, HAL, GLUD1",0.239577516576788,0.0319842860063582,FALSE
+"HCC15","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31908,1.01,0.418,5819,0.806,"CCL5, CHUK, MAPK8, MAPK14, IKBKG, NFKBIA, CASP8, MAPK13, CCL2, RELA, MAP3K7, CXCL8, HSP90AA1, MAPK9, HSP90AB1, NFKBIB, IL18, XIAP, PYCARD, NOD1, ERBIN, TAB2, TAB3, BIRC2, CARD6, TRAF6, BIRC3, SUGT1, MAPK3",0.378823718224965,0.0936649581949093,FALSE
+"HCC15","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.53642,1.71,0.023,4654,0.297,"XRCC5, NHEJ1, PRKDC, XRCC4, MRE11, DCLRE1C, FEN1, RAD50",1.63827216398241,0.527243550682788,FALSE
+"HCC15","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.22852,0.715,0.862,4999,1,"EGF, PDPK1, CASP9, RASSF5, E2F3, AKT1, ARAF, TGFA, MAP2K1, E2F2, HRAS, AKT2, NRAS, SOS1, CDK6, PIK3R1, RXRA, SOS2",0.0644927341752872,0,FALSE
+"HCC15","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.20514,-0.78,0.784,16674,0.939,"DTX1, DLL1, DVL2, SNW1, CTBP1, DVL3, APH1A, MFNG, NOTCH4, DTX4, EP300",0.105683937315562,0.0273344077338891,FALSE
+"HCC15","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.54037,1.67,0.0178,5582,0.255,"XPA, GTF2H1, ERCC3, POLE2, RFC5, POLE3, GTF2H3, RFC2, DDB2, DDB1, CUL4B, ERCC8, POLD3, RFC1, ERCC4, RPA2, RPA1, ERCC6, LIG1, POLD1, CCNH, GTF2H5, CDK7, RPA3, RPA4",1.74957999769111,0.593459819566045,FALSE
+"HCC15","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.38251,1.2,0.218,5764,0.546,"ALG9, MGAT5, MGAT5B, DPAGT1, GANAB, ALG1, B4GALT1, DPM2, STT3A, ALG6, ALG13, MAN2A2, ALG8, DPM3, DOLPP1, ALG2, ALG10, TUSC3, MAN1A1, RFT1, MGAT4B, STT3B, DDOST, MGAT2",0.661543506395395,0.262807357295263,FALSE
+"HCC15","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.28237,-1.08,0.346,8964,0.909,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR2AT4, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR2A42, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, ARRB2, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR51E2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, CNGA3, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2T33, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR56A3, OR10H2, OR10AD1, OR52B2, OR51M1, OR1B1, OR2L3, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR5M11, OR8G5, OR13G1, GUCA1B, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, CALML3, OR13D1, OR8D2, OR1J2, OR2S2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, ADCY3, OR2T8, OR2C1, OR8G1, OR4F15, OR52B6, OR2A25, OR2D3, OR1Q1, OR10H1, PRKACA, OR8A1, CALML5, OR2B2, OR1K1, OR2J3, OR10A6, OR2A2, OR4F3, OR10A4, GUCY2D, OR51B4, CAMK2A, OR13A1, OR6B2, OR2A12, OR2D2, OR2AG1, OR10A3, OR2K2, OR7C1, OR13H1, OR10A2, OR2A14, OR13J1, OR4F16, CLCA2, OR2H2, OR4F17, CNGB1, OR2W3, OR6A2, OR56B4, OR5K2, OR1L8, OR2AE1, OR1J1, OR2L2, CNGA4, CAMK2B, PDE1C, PRKG1, OR2AG2, PRKG2, GRK3",0.460923901207223,0.0414361167780325,FALSE
+"HCC15","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.47145,1.5,0.0579,3375,0.37,"ATIC, MTHFS, MTFMT, SHMT1, GART, DHFR",1.23732143627256,0.431798275933005,FALSE
+"HCC15","Input","KEGG_OOCYTE_MEIOSIS",0.53585,1.69,0.013,5147,0.272,"PPP2R1B, PTTG1, CDC25C, SLK, CDC23, ITPR1, INS, PLK1, CALM3, CHP1, ANAPC4, PPP2R5C, BUB1, CCNB1, BTRC, ADCY9, ADCY7, CALM1, PPP2R1A, PTTG2, CCNB2, ANAPC5, PPP2R5D, SKP1, SMC3, YWHAQ, CDK1, CDC20, FBXO5, MAP2K1, SMC1A, YWHAG, PRKACB, PPP1CC, PPP2R5A, ITPR3, PPP3R1, SGO1, ANAPC7, ESPL1, REC8, RPS6KA1, CDC27, PPP1CA, CCNE2, CDK2, IGF1R, PPP1CB, CALML6, YWHAZ, CUL1, ANAPC2, PPP2CB, CALM2, FBXW11, MAD2L2, PPP3CB",1.88605664769316,0.565431095965801,FALSE
+"HCC15","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.32405,1.01,0.423,2279,0.806,"FUCA1, FUCA2, MAN2C1",0.373659632624958,0.0936649581949093,FALSE
+"HCC15","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.24662,0.779,0.778,4667,1,"NDUFS3, ATP6V0A4, ATP5F1B, ATP6V0E1, ATP6V1E1, ATP6V1C1, ATP6V0A1, ATP6V1H, NDUFA9, ATP6V0B, ATP5MG, TCIRG1, ATP6V0D1, NDUFV3, PPA1, ATP6V0C, COX5A, NDUFB10, ATP5PO, COX15, NDUFA2, ATP6V1A, COX7A2, NDUFB1, ATP6V0E2, ATP5F1C, NDUFS1, NDUFAB1, ATP5MC3, ATP5F1D, COX8A, ATP6V1G1, ATP6V0A2, ATP5MC2, CYC1, COX4I1, SDHD",0.109020403010311,0,FALSE
+"HCC15","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.30754,-1.18,0.189,14442,0.924,"GALNT3, GALNTL6, ST6GALNAC1, GALNT15, GALNT9, GALNT13, GCNT4, GCNT1, GALNT16, GALNT14, ST3GAL1, GALNT18, GALNT7",0.723538195826756,0.0343280287798933,FALSE
+"HCC15","Input","KEGG_P53_SIGNALING_PATHWAY",0.30407,0.947,0.501,4224,0.898,"CCND3, CASP9, APAF1, CCNB1, CCNB2, PMAIP1, CHEK1, EI24, ATM, CDK1, DDB2, CASP8, RRM2, SERPINB5, PIDD1, CCNG1, BID, SFN, COP1, FAS, CCNE2, CDK2",0.300162274132754,0.0467236633326956,FALSE
+"HCC15","Input","KEGG_PANCREATIC_CANCER",0.28222,0.884,0.604,4555,0.973,"EGF, CHUK, CASP9, SMAD2, MAPK8, E2F3, AKT1, ARAF, TGFA, RAD51, BCL2L1, IKBKG, MAP2K1, CDC42, E2F2, RELA, MAPK9, AKT2, RALB, TGFB1, TGFBR2, CDK6",0.218963061378868,0.0118871597316481,FALSE
+"HCC15","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.24745,0.793,0.778,2722,1,"BCAT1, PPCDC, COASY",0.109020403010311,0,FALSE
+"HCC15","Input","KEGG_PARKINSONS_DISEASE",0.21586,0.682,0.896,4757,1,"NDUFS3, CASP9, VDAC2, APAF1, SLC18A2, ATP5F1B, PARK7, UCHL1, NDUFA9, UBE2J1, NDUFV3, COX5A, NDUFB10, UBE2G2, ATP5PO, NDUFA2, VDAC1, COX7A2, NDUFB1, ATP5F1C, NDUFS1, NDUFAB1, UBA1, ATP5MC3, ATP5F1D, COX8A, ATP5MC2, CYC1, COX4I1, SDHD, UBE2J2",0.0476919903378748,0,FALSE
+"HCC15","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.43743,1.4,0.0894,5551,0.375,"TUBAL3, CD14, ROCK2, ARPC2, WASL, ARPC5L, KRT18, ABL1, YWHAQ, LY96, ARPC3, CDC42, NCL, TUBB3, ARPC4, ARPC1A, TUBB2A, YWHAZ, ITGB1, TUBA1C, TUBB, TUBA4A, CTTN, TUBA1B, EZR, PRKCA, CDH1",1.04866248120408,0.425968732272281,FALSE
+"HCC15","Input","KEGG_PATHWAYS_IN_CANCER",0.2259,0.712,0.883,5626,0.998,"FGF9, COL4A6, FGF19, CSF2RA, EGF, KIT, CHUK, CASP9, EGLN1, RASSF5, SMAD2, SLC2A1, AXIN2, BMP4, PPARD, MAPK8, TRAF2, MSH2, TPR, E2F3, ABL1, CKS1B, AKT1, CTNNA1, ARAF, TGFA, CUL2, FZD3, RAD51, NCOA4, HDAC1, BCL2L1, GLI2, EGLN3, CTBP2, IKBKG, APC, NFKBIA, MAP2K1, CBL, CDC42, CASP8, WNT3, MSH3, E2F2, MSH6, PIAS1, COL4A4, PTGS2, MTOR, RELA, SUFU, APPL1, LEF1, JUP, ITGA2, HRAS, DVL1, LAMB3, CXCL8, BID, HSP90AA1, MAPK9, AKT2, RALB, FAS, HSP90AB1, CCNE2, NRAS, CDK2, TGFB1, PML, IGF1R, TGFBR2, ELOC, SOS1, XIAP, CDK6, TPM3, ITGA6, ITGB1, FZD9, VHL, FGF3, FZD6, PIK3R1, CCDC6, RXRA, SOS2, BIRC5, ELOB, TCF7, PTEN, BIRC2, LAMA1, TCF7L2, TRAF6, TRAF3, PRKCA, CDH1, FZD1, HDAC2, CRK, BIRC3, CDKN1B, LAMB2",0.0540392964224314,0.000869458712628891,FALSE
+"HCC15","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.48286,1.52,0.044,3070,0.353,"UGDH, RPEL1, GUSB, DCXR, RPE",1.35654732351381,0.452225294612177,FALSE
+"HCC15","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.53817,1.69,0.0211,3070,0.272,"PGD, TALDO1, G6PD, PFKP, RBKS, RPEL1, H6PD, GPI, TKT, ALDOA, RPE",1.67571754470231,0.565431095965801,FALSE
+"HCC15","Input","KEGG_PEROXISOME",0.28942,0.91,0.589,6744,0.936,"PRDX1, SCP2, SLC27A2, MPV17L, NUDT19, SOD1, DECR2, ABCD1, ACOX1, GNPAT, PEX6, PEX1, DHRS4, PECR, MPV17, PEX13, PEX14, PEX7, CRAT, GSTK1, FAR1, CROT, PEX16, PHYH, EPHX2, PEX3, ABCD3, ACSL3, SOD2, PEX11B, IDH1, PMVK, AGPS, ECI2, ACSL1",0.229884705212898,0.0287241512618947,FALSE
+"HCC15","Input","KEGG_PHENYLALANINE_METABOLISM",0.45266,1.41,0.085,3387,0.382,"ALDH3A1, PAH, PRDX6, ALDH3B1, GOT2, MAOA",1.07058107428571,0.417936637088291,FALSE
+"HCC15","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.22546,0.704,0.873,5224,0.992,"ITPR1, SYNJ1, CALM3, DGKG, CALM1, IPPK, PLCD4, IMPA1, PIKFYVE, DGKD, PIK3C2A, INPP5A, ITPK1, ITPR3, ITPKA, ITPKB, PLCD3, IMPA2, CALML6, PIK3R1, CALM2, DGKA, CDIPT, INPP1, PTEN",0.0589857562944303,0.00348832784582135,FALSE
+"HCC15","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.39101,1.23,0.167,1990,0.518,"HMBS, EARS2, BLVRA, UROS, GUSB, BLVRB",0.777283528852417,0.285670240254767,FALSE
+"HCC15","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.2493,0.794,0.776,1391,1,"SCP2, SLC27A2, PDPK1, ME1, PPARD, PPARA, CYP27A1",0.110138278741812,0,FALSE
+"HCC15","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.64526,2.01,0.00352,1700,0.212,"CYP39A1, SCP2, CYP27A1, HSD3B7",2.45345733652187,0.673664139071249,TRUE
+"HCC15","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.25478,-0.945,0.525,11935,1,"CD79A, CD8B, TAP2, AICDA, AIRE, RFXAP, BTK, CD3D, IL2RG, CIITA, IGLL1, LCK, RAG1, BLNK, CD8A, JAK3, RFX5, IL7R, RFXANK",0.279840696594043,0,FALSE
+"HCC15","Input","KEGG_PRION_DISEASES",0.24516,0.771,0.781,3165,1,"CCL5, STIP1, SOD1, MAP2K1, PRKACB, C5",0.1073489661227,0,FALSE
+"HCC15","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.42902,1.35,0.111,4818,0.363,"PDE3A, CDC25C, CDC23, INS, PLK1, ANAPC4, BUB1, CCNB1, ADCY9, ADCY7, MAPK8, CCNB2, ANAPC5, MAPK14, AKT1, ARAF, CDK1, MAP2K1, PRKACB, MAPK13, CDC25B, ANAPC7, GNAI1, HSP90AA1, MAPK9, AKT2, RPS6KA1, CDC27, GNAI3, HSP90AB1, CDK2, IGF1R, CCNA2, PIK3R1, ANAPC2",0.954677021213343,0.440093374963888,FALSE
+"HCC15","Input","KEGG_PROPANOATE_METABOLISM",0.32908,1.05,0.372,5284,0.76,"HADHA, ALDH9A1, LDHA, HIBCH, MCEE, ALDH3A2, ACAT1, ALDH2, ACACA, ECHS1, ACSS2, LDHAL6B, ALDH7A1, ACACB, LDHB",0.429457060118102,0.119186407719209,FALSE
+"HCC15","Input","KEGG_PROSTATE_CANCER",0.23815,0.752,0.821,4450,1,"EGF, CHUK, PDPK1, INS, CASP9, E2F3, AKT1, ARAF, TGFA, IKBKG, NFKBIA, MAP2K1, CREB3L2, E2F2, MTOR, RELA, LEF1, HRAS, HSP90AA1, AKT2, HSP90AB1, CCNE2, NRAS, CDK2, IGF1R, SOS1",0.0856568428805592,0,FALSE
+"HCC15","Input","KEGG_PROTEASOME",0.48553,1.52,0.0441,4892,0.353,"PSMC6, PSMA6, PSMA1, PSMC1, PSMA4, PSMC3, PSMB1, PSMA5, PSMB2, PSME2, PSMD1, PSMD14, PSMD8, PSMD13, PSMC2, PSMD4, PSMB7, PSME1, PSMD12, PSME4, PSMA2, PSMD7",1.35556141053216,0.452225294612177,FALSE
+"HCC15","Input","KEGG_PROTEIN_EXPORT",0.4637,1.48,0.0583,5209,0.354,"SRP54, SEC11A, SEC63, SRP9, SRPRA, SRP72, SRP19, SRP68, SEC61A2, SRP14, SPCS2, SEC61B",1.23433144524099,0.450996737974212,FALSE
+"HCC15","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.20006,-0.75,0.803,11762,0.912,"ATP1B4, ATP1A4, SLC9A3, ATP1B3, PCK1, GLS, GLS2, ATP1B2, PCK2, ATP1A2, FXYD2, SLC4A4, AQP1, ATP1A3, CA2",0.095284454721319,0.0400051616715838,FALSE
+"HCC15","Input","KEGG_PURINE_METABOLISM",0.39136,1.22,0.196,4668,0.53,"PDE7B, PDE8B, PDE4D, PDE3A, PDE8A, PDE10A, ADCY10, PDE4B, POLR2J2, PDE2A, ENTPD8, RRM1, ADCY9, ADCY7, POLE2, POLE3, ATIC, ADK, POLR2E, PDE9A, POLA1, PRIM1, POLR3K, POLR2D, NT5C2, POLR2A, NT5M, POLR1A, NT5E, NUDT5, RRM2, POLA2, PRIM2, POLR2C, POLD3, POLR3A, PKM, POLR2L, GART, NME3, PDE6D, PDE7A, AMPD3, POLR2G, AK2, NT5C3A, POLR3B, POLR1C, POLR1B, POLD1, GMPR2, APRT, GUK1, PRPS1, ADA",0.707743928643524,0.275724130399211,FALSE
+"HCC15","Input","KEGG_PYRIMIDINE_METABOLISM",0.38203,1.21,0.205,4243,0.534,"POLR2J2, CTPS1, ENTPD8, TXNRD1, DTYMK, RRM1, POLE2, POLE3, CMPK1, DHODH, POLR2E, POLA1, CDA, PRIM1, POLR3K, POLR2D, NT5C2, DUT, POLR2A, NT5M, POLR1A, NT5E, RRM2, POLA2, PRIM2, POLR2C, POLD3, POLR3A, POLR2L, CAD, NME3, POLR2G, UCK2, NT5C3A, POLR3B, POLR1C, POLR1B, POLD1",0.688246138944246,0.272458742971444,FALSE
+"HCC15","Input","KEGG_PYRUVATE_METABOLISM",0.38381,1.21,0.18,5284,0.534,"PC, ME1, DLAT, ME3, ALDH9A1, LDHA, ALDH3A2, ACAT1, GLO1, PKM, ALDH2, ACACA, DLD, ACSS2, LDHAL6B, ALDH7A1, ACACB, LDHB",0.744727494896694,0.272458742971444,FALSE
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+"HCC15","Input","KEGG_RNA_POLYMERASE",0.42722,1.36,0.107,4194,0.355,"POLR2J2, POLR2E, POLR3K, POLR2D, POLR2A, POLR1A, POLR2C, POLR3A, POLR2L, POLR2G, POLR3B, POLR1C, POLR1B",0.97061622231479,0.449771646944906,FALSE
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+"HCC15","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.25956,0.817,0.74,4869,1,"VAMP1, GOSR1, VTI1A, STX12, VAMP8, VAMP2, VAMP7, VAMP3, STX17, BNIP1, STX7, STX1A, STX4",0.130768280269024,0,FALSE
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+"HCC15","Input","KEGG_STEROID_BIOSYNTHESIS",-0.39613,-1.49,0.0647,16101,0.877,"CEL, SQLE, DHCR7, DHCR24, FDFT1, MSMO1",1.1890957193313,0.0570004066339595,FALSE
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+"HCC15","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.51342,1.6,0.0243,2030,0.298,"GGT5, GGT1, CSAD",1.61439372640169,0.525783735923745,FALSE
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+"HCC15","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.23666,0.741,0.855,5880,1,"PPP2R1B, ROCK2, SMAD2, BMP4, PPP2R1A, ZFYVE16, SKP1, BMPR1A, SMURF2, ID1, SP1, SMAD5, ID3, ZFYVE9, E2F4, ID2, TGFB1, TGFBR2, ACVR2A, SMAD6, BMPR2, CUL1, BMP8B, RBL1, PPP2CB, BMP6, SMAD7, BMP8A, MAPK3, TGFB2, ID4",0.0680338852718274,0,FALSE
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+"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.55596,1.73,0.015,1835,0.299,"IARS2, BCAT1",1.82390874094432,0.52432881167557,FALSE
+"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30615,0.966,0.493,3959,0.857,"HADHA, HADHB, ACADSB, AUH, ALDH9A1, HIBCH, BCAT1, MCEE, ALDH3A2, ACAT1, ALDH2, MCCC2, ACADS, DLD, ECHS1",0.30715308072277,0.0670191780768018,FALSE
+"HCC15","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.35015,1.12,0.275,2665,0.675,"PLA2G1B, ITPR1, ROCK2, GNA13, CALM3, RAMP1, ADCY9, ADCY7, CALM1, PRKCQ, MYLK2, PPP1R14A, ARAF, PLA2G4A, PRKCE, MAP2K1, ARHGEF12, PRKACB, PPP1CC",0.560667306169737,0.170696227168975,FALSE
+"HCC15","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.30806,0.983,0.467,2913,0.84,"DYNC1LI2, ADCY9, DYNC1H1, RAB11A, DCTN4, PRKACB, DCTN5, CREB3L2, VAMP2",0.330683119433888,0.0757207139381184,FALSE
+"HCC15","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.35817,1.14,0.261,3845,0.666,"PLA2G1B, NFAT5, CASP9, CHP1, MAPK14, AKT1, PLA2G4A, NFATC3, MAP2K1, CDC42, MAPK13, PTGS2, PPP3R1, HRAS, PXN, AKT2",0.583359492661719,0.176525770829699,FALSE
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+"HCC15","Input","KEGG_VIRAL_MYOCARDITIS",0.18245,0.57,0.979,5510,1,"CASP9, ABL1, CXADR, CASP8, EIF4G3, EIF4G2, BID, ITGB2, CD55, MYH10, CD40, ICAM1",0.00921730819686218,0,FALSE
+"HCC15","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31282,0.985,0.448,2177,0.845,"WIF1, PPP2R1B, NKD1, CCND3, NFAT5, NKD2, ROCK2, CHP1, VANGL1, SMAD2, PPP2R5C, TBL1X, AXIN2, BTRC, CSNK1E, PPARD, PPP2R1A, MAPK8, PPP2R5D, CACYBP, SKP1, FZD3, LRP5, NFATC3, CTBP2, APC",0.348721986001856,0.0731432910503077,FALSE
diff --git a/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_venn_diagram.pdf b/Examples/cell_corr/Fig4 - Coldren/GSEA/GSEA_venn_diagram.pdf
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diff --git a/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_correlation_matrix.pdf b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_correlation_matrix.pdf
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diff --git a/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_dot_plot.pdf b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_dot_plot.pdf
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diff --git a/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_interactive_network.graph.html b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
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--- /dev/null
+++ b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_interactive_network.graph.html	
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-eb7c39f33339e8d2effc" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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diff --git a/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..4ddc1a8
--- /dev/null
+++ b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_mean_results.csv	
@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"PPAR receptor agonist",0.760733333333333,1.23032280704042,0.000167330222373428,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2009, H2126, A549",0.000992029175499609
+"BCL inhibitor",0.635533333333333,0.752433657888727,0.836561136257018,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"estrogen receptor antagonist",0.6348,0.7965995767726,0.619806679699137,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.843343515000466
+"glutamate receptor antagonist",0.5856,0.638297042360149,0.984847949720954,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"bromodomain inhibitor",0.552333333333333,1.53481793553441,1.67475661741983e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,7,"H1650, H1975, H2126, H3255, A549, HCC15, H520",4.63349330819487e-06
+"NFkB pathway inhibitor",0.551266666666667,0.897440763398634,0.574122739243052,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466
+"progesterone receptor agonist",0.452733333333333,1.12256469534637,0.0792067067259401,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.156527539482215
+"RAF inhibitor",0.436466666666667,1.45366963562008,8.20395628825395e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H2009, H3255, H358",0.000619025792659162
+"MEK inhibitor",0.3912,1.29333330142366,0.0059568926836002,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, A549, H1299, H1703",0.0164807364246272
+"calcium channel blocker",0.324666666666667,0.894768658582179,0.936575671507874,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"AP inhibitor",0.305666666666667,1.14347419651483,0.179090655280002,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H1299",0.323141834526961
+"HCV inhibitor",0.291133333333333,1.16472607856751,0.125385739920975,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.236523100305476
+"dopamine receptor antagonist",0.2814,1.08058831859581,0.296291719929497,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.496090517959968
+"sodium channel blocker",0.2742,0.998864226437779,0.688490569239473,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.892886206982442
+"glucocorticoid receptor agonist",0.2734,1.00843271607834,0.686856431286151,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.892886206982442
+"glycogen synthase kinase inhibitor",0.2528,0.929019006417907,0.924657451668142,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"DNA inhibitor",0.230533333333333,1.03882583901707,0.60109875844015,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466
+"MDM inhibitor",0.219,1.52620547203093,0.00173738654258836,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H1975, H2009, H2126, H358",0.00721015415174168
+"acetylcholine receptor agonist",0.215,1.04121165681417,0.611873052665853,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466
+"acetylcholine receptor antagonist",0.212466666666667,1.55783127028143,6.62298560136289e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H1975, H2009, H3255, H520",0.000587172288938228
+"CC chemokine receptor antagonist",0.193866666666667,1.04814024870357,0.55328735014189,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.834960910214125
+"phosphatase inhibitor",0.179266666666667,1.23307521880788,0.0535737707699486,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.111165574347643
+"adenosine receptor antagonist",0.1662,1.44916508967849,0.0019634659533549,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, A549, HCC44, H1299",0.00776036543468841
+"TGF beta receptor inhibitor",0.164666666666667,1.47375345227594,0.00124386255483483,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"A549, HCC44, H1299, H520",0.00543371537112055
+"AKT inhibitor",0.135733333333333,1.39017144197946,0.00279190287394992,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"A549, H1299",0.00965533077241016
+"ribonucleotide reductase inhibitor",0.1266,1.42980846869182,0.000192611444883826,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H2126",0.00106578332835717
+"cytochrome P450 inhibitor",0.0991999999999999,1.65722863324803,0.000210499844621686,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1975, H2009, H3255, H460, H520",0.001091967943975
+"FGFR inhibitor",0.0948666666666667,1.25242809127292,0.0316161189959459,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0690562599121975
+"serotonin receptor antagonist",0.0828,1.19390052229776,0.0976336162332552,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.18845558482233
+"benzodiazepine receptor agonist",0.0255333333333334,0.769114041949443,0.99985851150393,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"ATPase inhibitor",0.0237333333333334,1.39353530206279,0.000122762043908677,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, A549, H1299",0.000783788434186171
+"proteasome inhibitor",0.0144,1.05288825889279,0.616305582678248,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466
+"FLT3 inhibitor",0.00433333333333337,1.06886693456647,0.532191529275925,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.817998091294478
+"HDAC inhibitor",-0.0038,1.27422380855394,0.00487149818162925,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, HCC15",0.0144405124669724
+"PARP inhibitor",-0.0094666666666666,1.28083231124289,0.00770212473874496,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H2126",0.0206218178488978
+"thymidylate synthase inhibitor",-0.0208666666666668,1.09927104851135,0.360719516250298,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.575763843245669
+"DNA alkylating agent",-0.0276666666666666,1.13523513402458,0.308551743330339,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.50215283718467
+"HMGCR inhibitor",-0.038,2.06637086976868,2.81192824270463e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,13,"HCC827, HCC95, H1975, H2009, H2126, H3255, H358, A549, HCC44, H1299, H1703, H460, H520",5.83475110361212e-06
+"opioid receptor agonist",-0.0645333333333334,1.13473576953697,0.260174734379682,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.4498854781982
+"CHK inhibitor",-0.0728,1.07417358267381,0.598640858831536,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.843343515000466
+"PI3K inhibitor",-0.0841333333333333,0.943188200176604,0.918379844835189,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"p38 MAPK inhibitor",-0.0984,1.40553760939669,0.0026088777916596,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC827, H3255, H1299",0.00941464594381506
+"retinoid receptor agonist",-0.0984,1.33723412844786,0.00335406356611246,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.0111354910394934
+"DNA polymerase inhibitor",-0.107733333333333,1.06385535178604,0.4938917724513,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.773453153084112
+"bacterial DNA gyrase inhibitor",-0.120266666666667,0.892620017273921,0.977915690015317,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"vitamin D receptor agonist",-0.137866666666667,1.98002257803385,2.37713878693295e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,11,"HCC827, H1650, H1975, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460",3.9460503863087e-05
+"serotonin receptor agonist",-0.146,1.48735527507241,1.32871492582267e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1975, A549, H1299",0.000183805564738803
+"DNA synthesis inhibitor",-0.1472,1.11410266262008,0.298849709614438,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.496090517959968
+"adrenergic receptor antagonist",-0.1498,0.697358198591554,0.999999633811902,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"mTOR inhibitor",-0.151933333333333,1.00343029273635,0.727742360780241,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.92927101453477
+"DNA methyltransferase inhibitor",-0.169733333333333,1.26712393500662,0.0261159889968523,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.0585845158578038
+"androgen receptor antagonist",-0.178866666666667,1.52011225462683,0.0022259745008619,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, HCC15, H520",0.00839799470779716
+"phosphodiesterase inhibitor",-0.1834,1.01448050041107,0.687697031419794,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.892886206982442
+"PDGFR tyrosine kinase receptor inhibitor",-0.191133333333333,0.986673622884101,0.80759389131879,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"estrogen receptor agonist",-0.199,0.848302675093877,0.98788418925686,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"protein tyrosine kinase inhibitor",-0.199466666666667,1.6350492725938,1.89078965213184e-09,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,9,"HCC827, HCC95, H1975, H2009, H3255, H358, A549, H1299, H1703",7.84677705634712e-08
+"antioxidant",-0.220733333333333,1.37947000519696,0.00113092001697756,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC15",0.00521479785606321
+"CDK inhibitor",-0.237933333333333,0.895274137319056,0.94493251729883,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"protein synthesis inhibitor",-0.238466666666667,1.2845231392381,0.00469548729435226,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H460, H520",0.0144342757567125
+"KIT inhibitor",-0.2428,0.910896983355261,0.91935815178424,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"Aurora kinase inhibitor",-0.2624,1.2426476227337,0.0125481218134206,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0306321797209974
+"VEGFR inhibitor",-0.263266666666667,0.883200225370917,0.967312380279596,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"tyrosine kinase inhibitor",-0.264933333333333,1.21988919090844,0.0740706728392538,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.149947947455075
+"histamine receptor antagonist",-0.2666,0.82455241538321,0.993197023505866,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"growth factor receptor inhibitor",-0.272,1.25695169812868,0.0144970697625136,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0343787654368179
+"potassium channel blocker",-0.2886,1.25660186898749,0.00961603897481951,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC44",0.0249416010909381
+"adrenergic receptor agonist",-0.328666666666667,0.786901216042728,0.994281906885891,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"microtubule inhibitor",-0.350066666666667,1.27105785339089,0.00367780830499553,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0117406957428703
+"JAK inhibitor",-0.353133333333333,0.962050478826098,0.74287148996616,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.934217176775626
+"EGFR inhibitor",-0.3608,1.91312799960095,0.0186105572783557,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,10,"HCC827, HCC95, H1975, H2009, H3255, H358, A549, HCC44, H1299, H1703",0.0429076737250979
+"topoisomerase inhibitor",-0.3652,1.35373410556558,6.13480429899034e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2126, H1299, H460",0.000587172288938228
+"cyclooxygenase inhibitor",-0.369666666666667,0.56398362016066,0.99999917867605,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"tubulin polymerization inhibitor",-0.428,1.35204506476036,7.0743649269666e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC15, H520",0.000587172288938228
+"MET inhibitor",-0.533,1.2487478871711,0.00105207995905694,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, HCC44",0.00513662568245446
+"src inhibitor",-0.594266666666667,1.45039051227428,5.4738702562375e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC827, HCC95, H2009, H358",0.000587172288938228
+"ALK tyrosine kinase receptor inhibitor",-0.612133333333333,0.963681769247998,0.224211661180687,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.395948252723341
+"bacterial 50S ribosomal subunit inhibitor",-0.6286,0.742863167557987,0.876568096064847,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999999633811902
+"RET tyrosine kinase inhibitor",-0.6768,1.16309968863992,0.0117308929723585,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H520",0.0295049732335076
+"HSP inhibitor",-0.6854,1.25184354339624,0.000104530131970241,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, HCC44",0.000723000079460835
+"PLK inhibitor",-0.703,1.6465416137208,1.64234033436046e-09,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,9,"HCC95, H1650, H1975, H2009, H2126, HCC15, H1299, H460, H520",7.84677705634712e-08
+"Abl kinase inhibitor",-0.719533333333333,0.999682654407792,0.0403688093965156,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0859131071771998
+"sterol demethylase inhibitor",-0.742533333333333,0.914146508003634,0.152412234108965,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.281115898467647
+"Bcr.Abl kinase inhibitor",-0.785066666666667,0.990250218499393,0.00515745474666957,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, A549",0.0147609911715026
diff --git a/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..9171bb8
--- /dev/null
+++ b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_results.csv	
@@ -0,0 +1,1246 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"HCC827","Pearson.est","EGFR inhibitor",-0.87589,-2.19,0,1339,0.00899,"brigatinib, GW.583340, BIBX.1382, CUDC.101, PD.153035, rociletinib, WZ8040, icotinib, AEE788, TAK.285, BIBU.1361, CP.724714, gefitinib, WZ.4002, ARRY.334543, AST.1306, BMS.599626, tucatinib, vandetanib, PD.168393, XL.647, erlotinib, neratinib, lapatinib, BMS.690514, dacomitinib, AZD8931, osimertinib, poziotinib, canertinib, pelitinib, afatinib",Inf,2.04624030826677,TRUE
+"HCC827","Pearson.est","Abl kinase inhibitor",-0.53942,-1.35,0.172,1415,0.436,"dasatinib, bosutinib, ZM.306416",0.764471553092451,0.360513510731414,FALSE
+"HCC827","Pearson.est","acetylcholine receptor agonist",0.35021,0.857,0.63,434,0.894,"tremorine, nicotine, nefiracetam",0.200659450546418,0.0486624812040823,FALSE
+"HCC827","Pearson.est","acetylcholine receptor antagonist",0.65991,1.57,0.0344,444,0.36,"dicycloverine, methscopolamine, iododexetimide, darifenacin, diphemanil",1.46344155742847,0.443697499232713,FALSE
+"HCC827","Pearson.est","adenosine receptor antagonist",-0.50206,-1.25,0.224,1354,0.514,"MRS.1220, CGS.15943",0.649751981665837,0.289036881004724,FALSE
+"HCC827","Pearson.est","adrenergic receptor agonist",-0.33107,-0.828,0.649,1133,0.965,"epinephrine, midodrine, metaraminol, isoxsuprine",0.187755303199631,0.0154726866562074,FALSE
+"HCC827","Pearson.est","adrenergic receptor antagonist",0.2948,0.737,0.797,406,0.947,"metoprolol, atenolol......, levobunolol, carvedilol, idazoxan, oxprenolol, atenolol....",0.0985416786038876,0.0236500209967266,FALSE
+"HCC827","Pearson.est","AKT inhibitor",-0.53725,-1.32,0.183,1070,0.446,"palomid.529, GSK2110183, AZD5363, A.674563, CCT128930, GDC.0068, uprosertib, triciribine",0.737548910269571,0.350665141287858,FALSE
+"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.61832,-1.53,0.071,1280,0.326,"NVP.TAE684, CEP.37440, brigatinib, GW.788388, AP26113, AZD3463",1.14874165128092,0.486782399932061,FALSE
+"HCC827","Pearson.est","androgen receptor antagonist",0.44791,1.1,0.342,553,0.757,"nilutamide, flutamide, bicalutamide",0.465973893943865,0.120904120499927,FALSE
+"HCC827","Pearson.est","antioxidant",0.44847,1.11,0.328,496,0.768,"taurine, chlorogenic.acid",0.484126156288321,0.114638779968488,FALSE
+"HCC827","Pearson.est","AP inhibitor",0.48078,1.16,0.287,351,0.694,"idronoxil, GDC.0152, LCL.161, birinapant",0.542118103266008,0.158640529545145,FALSE
+"HCC827","Pearson.est","ATPase inhibitor",0.62145,1.54,0.058,417,0.336,"digoxin, oligomycin.a, digitoxigenin, digitoxin, blebbistatin...., evodiamine, ouabain, NMS.873",1.23657200643706,0.473660722610156,FALSE
+"HCC827","Pearson.est","Aurora kinase inhibitor",0.26912,0.644,0.902,227,1,"MK.5108, barasertib, barasertib.HQPA, SNS.314",0.0447934624580583,0,FALSE
+"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.24339,0.6,0.929,426,1,"valnemulin, radezolid, josamycin",0.0319842860063582,0,FALSE
+"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.24101,-0.606,0.912,1331,0.94,"finafloxacin",0.0400051616715838,0.0268721464003014,FALSE
+"HCC827","Pearson.est","BCL inhibitor",0.4275,1.03,0.397,265,0.751,"ABT.737, TW.37, gossypol, venetoclax",0.401209493236885,0.124360062995832,FALSE
+"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.44138,-1.11,0.329,1415,0.68,"dasatinib, bosutinib",0.482804102050026,0.167491087293764,FALSE
+"HCC827","Pearson.est","benzodiazepine receptor agonist",0.24458,0.587,0.927,529,1,"bentazepam, indiplon, zaleplon, nefiracetam, CL.218872, lorazepam",0.0329202658555029,0,FALSE
+"HCC827","Pearson.est","bromodomain inhibitor",-0.26859,-0.659,0.849,919,0.944,"PFI.1, OTX015, I.BET151, I.BET.762, JQ1....",0.0710923097560473,0.025028005701931,FALSE
+"HCC827","Pearson.est","calcium channel blocker",0.49347,1.2,0.266,103,0.674,"carboxyamidotriazole, pranidipine, mibefradil",0.575118363368933,0.17134010346468,FALSE
+"HCC827","Pearson.est","CC chemokine receptor antagonist",0.35363,0.871,0.612,326,0.893,"SB.225002, UNBS.5162",0.213248577854439,0.0491485411114536,FALSE
+"HCC827","Pearson.est","CDK inhibitor",0.17028,0.423,0.996,693,0.995,"abemaciclib, dinaciclib, NU6027, palbociclib, P276.00, R547, indirubin, BMS.387032, AZD5438, PHA.848125, ribociclib",0.00174066157630127,0.00217691925427455,FALSE
+"HCC827","Pearson.est","CHK inhibitor",-0.45868,-1.1,0.35,1210,0.658,"CHIR.124, LY2603618",0.455931955649724,0.181774106386044,FALSE
+"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.2862,-0.697,0.815,1240,0.926,"tryptanthrin, FK.3311, ketoprofen, aspirin, phenazone, ramifenazone",0.0888423912600234,0.0333890133180656,FALSE
+"HCC827","Pearson.est","cytochrome P450 inhibitor",0.67592,1.64,0.0409,474,0.825,"metyrapone, clotrimazole, cobicistat, morin, itraconazole, eplerenone, PF.4981517",1.38827669199266,0.0835460514500749,FALSE
+"HCC827","Pearson.est","DNA alkylating agent",0.47989,1.17,0.288,244,0.705,"carboplatin, carmustine, dianhydrogalactitol, TH.302, temozolomide, streptozotocin, cisplatin",0.540607512240769,0.151810883008601,FALSE
+"HCC827","Pearson.est","DNA inhibitor",0.51846,1.26,0.206,153,0.618,"pibenzimol, carboplatin, chlorambucil, carmustine, valrubicin",0.686132779630847,0.209011524911184,FALSE
+"HCC827","Pearson.est","DNA methyltransferase inhibitor",-0.43421,-1.08,0.346,1262,0.655,"azacitidine, SGI.1027, fdcyd, decitabine",0.460923901207223,0.183758700008217,FALSE
+"HCC827","Pearson.est","DNA polymerase inhibitor",0.27659,0.681,0.861,206,1,"menadione, foscarnet",0.0649968485463452,0,FALSE
+"HCC827","Pearson.est","DNA synthesis inhibitor",0.56241,1.39,0.115,430,0.522,"altretamine, artemisinin, cisplatin, cyclocytidine, azodicarbonamide, nelarabine, artesunate, estramustine.phosphate",0.939302159646388,0.282329496997738,FALSE
+"HCC827","Pearson.est","dopamine receptor antagonist",0.3726,0.922,0.531,151,0.852,"raclopride, paliperidone, amisulpride, isofloxythepin",0.274905478918531,0.0695604052332999,FALSE
+"HCC827","Pearson.est","estrogen receptor agonist",-0.23101,-0.588,0.923,1167,0.926,"ethinyl.estradiol, levonorgestrel",0.0347982989740879,0.0333890133180656,FALSE
+"HCC827","Pearson.est","estrogen receptor antagonist",0.30921,0.742,0.776,222,0.962,"fulvestrant, danazol",0.110138278741812,0.0168249279621871,FALSE
+"HCC827","Pearson.est","FGFR inhibitor",0.53219,1.29,0.185,479,0.627,"erdafitinib, dovitinib, orantinib, regorafenib, lenvatinib, nintedanib",0.732828271596986,0.202732459169284,FALSE
+"HCC827","Pearson.est","FLT3 inhibitor",0.32677,0.777,0.732,671,0.932,"dovitinib, TG.101348, GTP.14564, ENMD.2076, ponatinib, tyrphostin.AG.1296, tozasertib, sunitinib, KW.2449, sorafenib, gilteritinib",0.135488918941608,0.0305840876460186,FALSE
+"HCC827","Pearson.est","glucocorticoid receptor agonist",0.32466,0.778,0.708,404,0.954,"piretanide, dexamethasone.acetate, halcinonide, triamcinolone, prednisolone.hemisuccinate, flumethasone.pivalate, deflazacort, fluticasone.propionate",0.149966742310231,0.0204516252959049,FALSE
+"HCC827","Pearson.est","glutamate receptor antagonist",0.43596,1.08,0.353,237,0.766,"felbamate, MTPG, CPP, ACDPP",0.452225294612177,0.115771230367396,FALSE
+"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.30594,-0.755,0.735,1403,0.94,"LY2090314",0.133712660915805,0.0268721464003014,FALSE
+"HCC827","Pearson.est","growth factor receptor inhibitor",-0.48037,-1.2,0.241,1047,0.559,"GSK1904529A, GSK1838705A, AZD3463",0.617982957425132,0.252588192113577,FALSE
+"HCC827","Pearson.est","HCV inhibitor",0.55059,1.34,0.158,201,0.598,"mericitabine, Ro.9187",0.801342913045577,0.223298816011589,FALSE
+"HCC827","Pearson.est","HDAC inhibitor",-0.31618,-0.786,0.659,999,0.921,"chidamide, trichostatin.a, belinostat, vorinostat, RG2833, SB.939, PCI.24781, mocetinostat, tacedinaline, givinostat, panobinostat, JNJ.26481585",0.18111458540599,0.0357403698031511,FALSE
+"HCC827","Pearson.est","histamine receptor antagonist",-0.29748,-0.752,0.746,1326,0.91,"ebastine, terfenadine, zolantidine, ranitidine",0.127261172527331,0.0409586076789064,FALSE
+"HCC827","Pearson.est","HMGCR inhibitor",0.92284,2.27,0,26,0.00108,"atorvastatin, mevastatin, fluvastatin, pitavastatin",Inf,2.96657624451305,TRUE
+"HCC827","Pearson.est","HSP inhibitor",-0.62481,-1.6,0.0696,1223,0.315,"guanidine, XL888, KW.2478, PU.H71, alvespimycin, VER.49009, BIIB021, tanespimycin",1.15739076038944,0.501689446210399,FALSE
+"HCC827","Pearson.est","JAK inhibitor",-0.32706,-0.792,0.67,1327,0.949,"LY2784544, CEP.33779, ruxolitinib",0.173925197299174,0.0227337875727074,FALSE
+"HCC827","Pearson.est","KIT inhibitor",0.23204,0.556,0.949,409,0.991,"pazopanib, motesanib, cediranib, regorafenib, KI.8751, lenvatinib",0.0227337875727074,0.00392634551472468,FALSE
+"HCC827","Pearson.est","MDM inhibitor",0.65014,1.58,0.0556,70,0.48,"AMG.232, idasanutlin, nutlin.3",1.25492520841794,0.318758762624413,FALSE
+"HCC827","Pearson.est","MEK inhibitor",-0.57674,-1.46,0.0989,1087,0.316,"PD.98059, PD.0325901, selumetinib, MEK1.2.inhibitor, PD.198306, refametinib, AS.703026, AZD8330, PD.184352, TAK.733, Ro.4987655, trametinib",1.00480370840282,0.500312917381596,FALSE
+"HCC827","Pearson.est","MET inhibitor",-0.57239,-1.47,0.0804,1150,0.333,"PF.04217903, LY2801653, INC.280",1.09474395125155,0.47755576649368,FALSE
+"HCC827","Pearson.est","microtubule inhibitor",0.41152,1.01,0.434,430,0.738,"secnidazole, vinblastine, triclabendazole, vinflunine, estramustine.phosphate",0.362510270487489,0.131943638176958,FALSE
+"HCC827","Pearson.est","mTOR inhibitor",0.25857,0.635,0.882,551,1,"ku.0063794, XL388, OSI.027, SB.2343, torin.1, deforolimus, AZD2014, WAY.600, MLN0128, PF.04691502, LY3023414, PI.103",0.0545314148681803,0,FALSE
+"HCC827","Pearson.est","NFkB pathway inhibitor",0.49243,1.21,0.233,506,0.688,"BAY.11.7082, betulinic.acid, parthenolide, tyloxapol, curcumin, IKK.2.inhibitor.V, EVP4593",0.632644078973981,0.162411561764489,FALSE
+"HCC827","Pearson.est","opioid receptor agonist",-0.28724,-0.701,0.823,1350,0.954,"ADL5859",0.0846001647877302,0.0204516252959049,FALSE
+"HCC827","Pearson.est","p38 MAPK inhibitor",-0.77205,-1.92,0.00227,1128,0.0562,"talmapimod, CMPD.1, SB.242235, VX.702, SB.239063, TAK.715",2.64397414280688,1.25026368443094,TRUE
+"HCC827","Pearson.est","PARP inhibitor",0.42298,1.01,0.441,466,0.738,"AG.14361, endo.IWR.1, AZD2461, talazoparib",0.355561410532161,0.131943638176958,FALSE
+"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.36762,0.886,0.609,505,0.893,"pazopanib, dovitinib, motesanib, orantinib, CP.673451, SU014813, axitinib, regorafenib, KI.8751, linifanib, lenvatinib, ponatinib, nintedanib, telatinib",0.215382707367125,0.0491485411114536,FALSE
+"HCC827","Pearson.est","phosphatase inhibitor",0.59026,1.43,0.112,164,0.478,"bis.maltolato.oxovanadium.IV., GSK2830371, menadione, BVT.948",0.950781977329818,0.320572103387881,FALSE
+"HCC827","Pearson.est","phosphodiesterase inhibitor",0.41996,1.03,0.421,61,0.751,"anagrelide, GSK256066",0.375717904164332,0.124360062995832,FALSE
+"HCC827","Pearson.est","PI3K inhibitor",-0.25894,-0.654,0.878,1303,0.92,"PIK.75, TG.100713, CH5132799, alpelisib, taselisib",0.0565054840938974,0.0362121726544447,FALSE
+"HCC827","Pearson.est","PLK inhibitor",-0.33737,-0.835,0.617,1145,0.996,"BI.2536, HMN.214, NMS.1286937",0.209714835966758,0.00174066157630127,FALSE
+"HCC827","Pearson.est","potassium channel blocker",0.42736,1.04,0.421,253,0.788,"mepivacaine, dofetilide",0.375717904164332,0.103473782510445,FALSE
+"HCC827","Pearson.est","PPAR receptor agonist",0.44061,1.07,0.383,21,0.756,"clofibrate",0.416801226031377,0.121478204498793,FALSE
+"HCC827","Pearson.est","progesterone receptor agonist",0.52352,1.28,0.188,261,0.609,"norethindrone, tanaproget, norethindrone.acetate, danazol, norgestrel",0.72584215073632,0.215382707367125,FALSE
+"HCC827","Pearson.est","proteasome inhibitor",0.53942,1.32,0.161,144,0.598,"MG.132, oprozomib",0.79317412396815,0.223298816011589,FALSE
+"HCC827","Pearson.est","protein synthesis inhibitor",0.32788,0.811,0.686,432,0.95,"mercaptopurine, florfenicol, brefeldin.a, harringtonine, thiostrepton, clofoctol, methacycline",0.163675884293248,0.0222763947111523,FALSE
+"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.77439,-1.88,0.0136,1334,0.0654,"NVP.TAE226, CP.724714, BMS.599626, AV.412",1.86646109162978,1.18442225167573,TRUE
+"HCC827","Pearson.est","RAF inhibitor",0.66353,1.61,0.0344,78,0.667,"dabrafenib, vemurafenib, SB.590885, TAK.632, AZ.628",1.46344155742847,0.175874166083451,FALSE
+"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.59339,-1.5,0.0776,1430,0.327,"vandetanib",1.11013827874181,0.485452247339714,FALSE
+"HCC827","Pearson.est","retinoid receptor agonist",-0.32268,-0.797,0.652,1273,0.982,"adarotene, tamibarotene, CD.437",0.18575240426808,0.00788851221305034,FALSE
+"HCC827","Pearson.est","ribonucleotide reductase inhibitor",0.65337,1.59,0.0536,148,0.568,"cladribine, triapine, pentostatin, clofarabine, hydroxyurea",1.27083521030723,0.245651664288981,FALSE
+"HCC827","Pearson.est","serotonin receptor agonist",0.64701,1.57,0.0552,1,0.36,"aripiprazole",1.2580609222708,0.443697499232713,FALSE
+"HCC827","Pearson.est","serotonin receptor antagonist",0.62152,1.54,0.0617,89,0.336,"aripiprazole, lerisetron, paliperidone, pirenperone",1.20971483596676,0.473660722610156,FALSE
+"HCC827","Pearson.est","sodium channel blocker",0.60362,1.51,0.0669,186,0.357,"cibenzoline, butamben, mepivacaine, benzethonium, quinidine, oxcarbazepine",1.17457388223218,0.447331783887807,FALSE
+"HCC827","Pearson.est","src inhibitor",-0.82886,-2.09,0,1415,0.0189,"dasatinib, bosutinib, ZM.306416, saracatinib",Inf,1.72353819582676,TRUE
+"HCC827","Pearson.est","sterol demethylase inhibitor",0.40715,0.997,0.472,74,0.738,"posaconazole",0.326058001365912,0.131943638176958,FALSE
+"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.33738,-0.853,0.609,1110,1,"D.4476, SB.431542, repsox",0.215382707367125,0,FALSE
+"HCC827","Pearson.est","thymidylate synthase inhibitor",0.22798,0.563,0.955,436,1,"doxifluridine, ftorafur",0.0199966284162537,0,FALSE
+"HCC827","Pearson.est","topoisomerase inhibitor",0.32487,0.797,0.706,290,0.949,"doxorubicin, etoposide.phosphate, epirubicin, valrubicin, beta.lapachone, voreloxin, dexrazoxane, nemorubicin, teniposide",0.151195298948196,0.0227337875727074,FALSE
+"HCC827","Pearson.est","tubulin polymerization inhibitor",0.19021,0.459,0.995,309,1,"taltobulin, vindesine, vinblastine, vinorelbine, BNC105, verubulin",0.00217691925427455,0,FALSE
+"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.62052,-1.55,0.0748,1334,0.339,"NVP.TAE226, aminopurvalanol.a, tivantinib, dasatinib, CP.724714, BMS.599626, vandetanib, AV.412",1.12609840213554,0.469800301796918,FALSE
+"HCC827","Pearson.est","VEGFR inhibitor",-0.41588,-1.01,0.451,1411,0.744,"AEE788, ZM.306416, vandetanib, XL.647, BMS.690514",0.345823458122039,0.128427064454121,FALSE
+"HCC827","Pearson.est","vitamin D receptor agonist",-0.81049,-1.95,0,1246,0.0569,"calcitriol, paricalcitol, tacalcitol, ercalcitriol, maxacalcitol",Inf,1.24488773360493,TRUE
+"HCC95","Pearson.est","EGFR inhibitor",-0.79651,-1.91,0.00531,1326,0.0578,"WZ.4002, BMS.599626, icotinib, GW.583340, BIBX.1382, rociletinib, tucatinib, CP.724714, TAK.285, brigatinib, ARRY.334543, AEE788, PD.168393, vandetanib, gefitinib, AST.1306, osimertinib, canertinib, neratinib, pelitinib, dacomitinib, BMS.690514, AZD8931, erlotinib, afatinib, poziotinib, lapatinib, XL.647",2.27490547891853,1.23807216157947,TRUE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.64044,-1.54,0.0724,1237,0.2,"metatinib, imatinib, tozasertib, ZM.306416, dasatinib, bosutinib",1.14026143380285,0.698970004336019,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.32434,0.896,0.543,191,0.706,"nicotine, nefiracetam",0.265200170411153,0.151195298948196,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",0.56651,1.57,0.0556,287,0.252,"diphemanil, dicycloverine, iododexetimide",1.25492520841794,0.598599459218456,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",-0.49369,-1.19,0.259,1406,0.479,"CGS.15943",0.586700235918748,0.319664486585437,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",-0.295,-0.701,0.812,773,0.959,"metaraminol, oxymetazoline, norepinephrine, A61603, epinephrine, clenbuterol, midodrine, isoxsuprine, buphenine",0.0904439707588247,0.0181813928293364,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",-0.27045,-0.631,0.883,869,0.973,"dihydroergocristine, pindolol, atipamezole, dronedarone, vincamine, idazoxan, naftidrofuryl, RS.17053, practolol",0.0540392964224314,0.0118871597316481,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.46959,-1.09,0.384,1058,0.612,"ONC201, A.674563, CCT128930, uprosertib, triciribine",0.415668775632469,0.213248577854439,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.65596,-1.56,0.0427,1096,0.287,"alectinib, SB.505124, NVP.TAE684, lorlatinib, GW.788388, crizotinib, AZD3463, AP26113, brigatinib",1.36957212497498,0.542118103266008,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",0.47349,1.34,0.142,355,0.328,"bicalutamide, nilutamide, RU.58841, flutamide",0.847711655616944,0.484126156288321,FALSE
+"HCC95","Pearson.est","antioxidant",0.51443,1.44,0.131,340,0.273,"trolox, benfotiamine, mesna, taurine",0.882728704344236,0.563837352959244,FALSE
+"HCC95","Pearson.est","AP inhibitor",0.6975,1.96,0.0198,251,0.098,"idronoxil, GDC.0152, LCL.161",1.70333480973847,1.00877392430751,TRUE
+"HCC95","Pearson.est","ATPase inhibitor",-0.19584,-0.469,0.989,1158,1,"digitoxigenin, k.strophanthidin",0.0048037084028206,0,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",-0.56769,-1.36,0.146,903,0.356,"ZM.447439, MLN.8054, KW.2449, AT.9283, alisertib, MK.8745, ENMD.2076, aurora.a.inhibitor.i, TAK.901, CCT129202, PF.03814735, CYC116, barasertib, PHA.680632, danusertib, tozasertib, GSK1070916, hesperadin",0.835647144215563,0.448550002027125,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.43856,-1.06,0.379,1129,0.628,"azithromycin, tedizolid",0.421360790031928,0.202040356262804,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.42097,1.14,0.311,278,0.471,"sparfloxacin, norfloxacin, sarafloxacin, nadifloxacin",0.507239610973163,0.326979092871104,FALSE
+"HCC95","Pearson.est","BCL inhibitor",0.2468,0.674,0.841,20,0.908,"ABT.737",0.0752040042020878,0.0419141514789149,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.64196,-1.54,0.0461,1237,0.2,"metatinib, imatinib, tozasertib, dasatinib, bosutinib",1.33629907461035,0.698970004336019,TRUE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",0.4647,1.27,0.18,191,0.381,"indiplon, zaleplon, temazepam, nefiracetam",0.744727494896694,0.419075024324381,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",0.52547,1.45,0.128,246,0.288,"bromosporine, I.BET151, PFI.1",0.892790030352132,0.540607512240769,FALSE
+"HCC95","Pearson.est","calcium channel blocker",-0.35359,-0.843,0.666,1223,0.819,"SKF.96365, penfluridol",0.176525770829699,0.0867160982395816,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",0.22396,0.62,0.902,84,0.936,"SB.225002",0.0447934624580583,0.0287241512618947,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.55669,-1.33,0.154,959,0.368,"dinaciclib, ribociclib, BMS.387032, AZD5438, JNJ.7706621, BMS.265246, R547, palbociclib, alvocidib, PHA.793887, AT.7519, aminopurvalanol.a, PHA.848125, indisulam",0.812479279163537,0.434152181326482,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.38846,-0.93,0.569,782,0.779,"LY2606368, AZD7762, CHIR.124, LY2603618",0.244887733604929,0.108462542327436,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.19378,-0.464,0.985,1062,0.988,"AM.404, ramifenazone, FK.3311, amfenac, aspirin, phenazone",0.00656376950238827,0.00524305541237188,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.55149,1.48,0.0952,339,0.284,"metyrapone, clotrimazole, cobicistat, morin",1.02136305161553,0.546681659952962,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.43797,-1.05,0.403,1189,0.608,"estramustine, cyclophosphamide, mitomycin.c, dacarbazine",0.39469495385889,0.216096420727265,FALSE
+"HCC95","Pearson.est","DNA inhibitor",0.44048,1.19,0.276,258,0.431,"pibenzimol, chlorambucil, bendamustine, melphalan, carboplatin",0.559090917934782,0.365522729839268,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.64487,-1.54,0.045,1317,0.2,"fdcyd, azacitidine, decitabine",1.34678748622466,0.698970004336019,TRUE
+"HCC95","Pearson.est","DNA polymerase inhibitor",0.29477,0.79,0.646,29,0.86,"menadione",0.189767482004916,0.0655015487564323,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.29483,-0.703,0.812,875,0.979,"altretamine, floxuridine, cyclocytidine, CB.10.277, enocitabine, capecitabine, anisomycin, mitomycin.c",0.0904439707588247,0.00921730819686218,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",0.341,0.942,0.497,343,0.66,"amisulpride, raclopride, sertindole, domperidone, paliperidone, remoxipride, nemonapride, lurasidone",0.303643611266668,0.180456064458131,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.433,-1.03,0.417,1112,0.623,"ethinyl.estradiol, levonorgestrel",0.379863945026242,0.20551195334083,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",0.49594,1.34,0.158,250,0.328,"toremifene, fulvestrant, danazol",0.801342913045577,0.484126156288321,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",-0.38835,-0.911,0.568,923,0.769,"nintedanib, AZD4547, MK.2461, PD.173074, dovitinib, lenvatinib, lucitanib",0.245651664288981,0.114073660198569,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",-0.45795,-1.11,0.338,850,0.596,"tyrphostin.AG.1296, quizartinib, ponatinib, lestaurtinib, KW.2449, sunitinib, dovitinib, gilteritinib, ENMD.2076, midostaurin, pacritinib, sorafenib, tozasertib",0.471083299722345,0.224753740259764,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.24566,-0.592,0.925,777,0.966,"rimexolone, fluocinolone.acetonide, methylprednisolone, fludroxycortide, fluticasone.propionate, flumethasone.pivalate, desonide, prednisolone.acetate, clobetasol.propionate, halobetasol.propionate, difluprednate, hydrocortisone, fluorometholone, triamcinolone.acetonide, betamethasone, ciclesonide, flumethasone",0.0338582672609674,0.0150228735845067,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",0.34253,0.949,0.503,269,0.677,"MTPG, ACDPP, JNJ.16259685, felbamate, IEM1754",0.298432014944073,0.169411331314856,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.2467,0.676,0.839,1093,0.937,"CHIR.98014, CHIR.99021, GSK.3.inhibitor.IX, indirubin, tideglusib, kenpaullone, AZD2858, TWS.119, LY2090314",0.0762380391712997,0.0282604091122217,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.64875,-1.57,0.0431,1185,0.306,"GSK1838705A, danusertib, AZD3463, PHA.848125",1.36552272983927,0.51427857351842,FALSE
+"HCC95","Pearson.est","HCV inhibitor",0.57327,1.57,0.0686,120,0.252,"mericitabine, Ro.9187",1.16367588429325,0.598599459218456,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.35418,-0.856,0.65,860,0.818,"RGFP966, trichostatin.a, JNJ.26481585, SB.939, romidepsin, panobinostat, tacedinaline, givinostat, resminostat, dacinostat, belinostat, vorinostat, chidamide",0.187086643357144,0.087246696328677,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",-0.28589,-0.684,0.839,1027,0.938,"terfenadine, BF2.649, ranitidine, zolantidine, ebastine, levocetirizine",0.0762380391712997,0.0277971616209356,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.7865,2.15,0.0134,285,0.101,"atorvastatin, mevastatin, fluvastatin, simvastatin, pitavastatin",1.87289520163519,0.995678626217357,TRUE
+"HCC95","Pearson.est","HSP inhibitor",-0.70905,-1.73,0.0231,1220,0.162,"alvespimycin, XL888, tanespimycin, ganetespib, NVP.AUY922, VER.49009, PU.H71, BIIB021",1.63638802010786,0.790484985457369,TRUE
+"HCC95","Pearson.est","JAK inhibitor",-0.56921,-1.38,0.125,910,0.412,"lestaurtinib, TG.101209, filgotinib, PRT062070, AT.9283, AZ960, LY2784544, baricitinib, WHI.P154, AZD1480, pacritinib, tozasertib, CEP.33779, ruxolitinib",0.903089986991944,0.385102783966865,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.50623,-1.2,0.261,1184,0.48,"lenvatinib, midostaurin, sorafenib, imatinib, dasatinib",0.583359492661719,0.318758762624413,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.74932,2.04,0.00397,150,0.0742,"AMG.232, idasanutlin, CGM097, nutlin.3",2.40120949323688,1.12959609472097,TRUE
+"HCC95","Pearson.est","MEK inhibitor",0.57934,1.58,0.0584,220,0.313,"U.0126, cobimetinib, selumetinib, MEK1.2.inhibitor, BIX.02188, MEK162, refametinib, AS.703026, PD.318088",1.2335871528876,0.504455662453552,FALSE
+"HCC95","Pearson.est","MET inhibitor",-0.6514,-1.57,0.048,1388,0.306,"INC.280, LY2801653",1.31875876262441,0.51427857351842,FALSE
+"HCC95","Pearson.est","microtubule inhibitor",-0.58123,-1.38,0.118,958,0.412,"vinblastine, cytochalasin.b, triclabendazole, colchicine, vinflunine, podophyllotoxin, D.64131, cabazitaxel",0.928117992693875,0.385102783966865,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.37838,-0.903,0.584,905,0.762,"PKI.179, MLN0128, temsirolimus, WYE.354, NVP.BEZ235, torin.1, voxtalisib, GSK2126458, AZD8055, GDC.0980, PF.05212384, sirolimus, deforolimus, everolimus, torin.2",0.233587152887601,0.1180450286604,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",0.35237,0.951,0.492,942,0.704,"tyloxapol, BAY.11.7082, parthenolide, parthenolide...., IKK.2.inhibitor.V, bindarit, bortezomib, betulinic.acid, Ro.106.9920, curcumin, BAY.11.7085, EVP4593",0.30803489723264,0.152427340857888,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",0.39186,1.09,0.336,42,0.522,"BW.180C",0.473660722610156,0.282329496997738,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",-0.51498,-1.23,0.235,879,0.464,"skepinone.l, CMPD.1, SB.239063, SB.242235, talmapimod",0.628932137728264,0.333482019445119,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.56036,-1.36,0.138,1279,0.356,"niraparib, olaparib, talazoparib",0.860120913598763,0.448550002027125,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.44813,-1.08,0.369,1184,0.611,"lenvatinib, axitinib, crenolanib, sorafenib, imatinib, CP.673451, dasatinib",0.43297363384094,0.213958789757446,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.56564,1.55,0.0752,56,0.244,"bis.maltolato.oxovanadium.IV., menadione, BVT.948, GSK2830371",1.12378215940836,0.612610173661271,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.36521,0.998,0.403,143,0.649,"anagrelide, enoximone, GSK256066",0.39469495385889,0.187755303199631,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.38275,-0.924,0.539,1033,0.768,"NVP.BEZ235, GDC.0941, voxtalisib, GSK2126458, GDC.0980, PF.05212384, TG.100713, taselisib, PIK.75, CH5132799, alpelisib",0.268411234813261,0.114638779968488,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.79433,-1.9,0,1264,0.0431,"HMN.214, GSK461364, BI.2536, rigosertib, volasertib, NMS.1286937",Inf,1.36552272983927,TRUE
+"HCC95","Pearson.est","potassium channel blocker",-0.33921,-0.819,0.689,1261,0.837,"ibutilide",0.161780778092374,0.07727454200674,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.60692,1.68,0.0435,265,0.312,"GW.501516, fenofibrate, pterostilbene, clofibrate",1.36151074304536,0.505845405981557,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",0.59248,1.67,0.0365,40,0.268,"norethindrone.acetate, norgestrel, norethindrone, tanaproget",1.43770713554353,0.571865205971211,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",0.44129,1.23,0.198,238,0.406,"oprozomib, ONX.0914, MG.132",0.703334809738469,0.391473966422806,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",-0.507,-1.2,0.251,1162,0.48,"anguidine, thiostrepton, bruceantin, tedizolid.phosphate, homoharringtonine, puromycin, cycloheximide",0.600326278518962,0.318758762624413,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.71356,-1.7,0.00997,1293,0.167,"NVP.TAE226, BMS.599626, CP.724714, AV.412",2.00130484168834,0.777283528852417,TRUE
+"HCC95","Pearson.est","RAF inhibitor",0.79542,2.14,0,92,0.0553,"dabrafenib, vemurafenib, AZ.628, GDC.0879, LGX818, PLX.4720, SB.590885, TAK.632",Inf,1.2572748686953,TRUE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.65561,-1.55,0.0442,1200,0.245,"cabozantinib, sorafenib, vandetanib",1.35457773065091,0.610833915635468,TRUE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.2603,-0.619,0.902,1126,0.964,"tamibarotene, CD.437",0.0447934624580583,0.0159229660971692,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.2533,0.703,0.776,170,0.935,"pentostatin, triapine",0.110138278741812,0.0291883891274822,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.5594,-1.34,0.156,1179,0.37,"pardoprunox, aripiprazole",0.806875401645538,0.431798275933005,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",-0.28985,-0.691,0.827,1192,0.95,"RS.16566, SB.200646, SB.228357, aripiprazole",0.0824944904474534,0.0222763947111523,FALSE
+"HCC95","Pearson.est","sodium channel blocker",0.27707,0.747,0.74,63,0.9,"cibenzoline, benzethonium",0.130768280269024,0.0457574905606751,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.83057,-1.99,0,1414,0.0308,"ZM.306416, dasatinib, bosutinib, saracatinib",Inf,1.51144928349956,TRUE
+"HCC95","Pearson.est","sterol demethylase inhibitor",-0.53227,-1.28,0.212,999,0.397,"ketoconazole, terconazole, lanoconazole",0.673664139071249,0.401209493236885,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.43307,-1.05,0.405,1149,0.608,"D.4476, repsox",0.392544976785331,0.216096420727265,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.57623,-1.36,0.109,1151,0.356,"capecitabine, raltitrexed, carmofur",0.962573502059376,0.448550002027125,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",-0.54554,-1.3,0.175,1040,0.4,"amonafide, licochalcone.a, daunorubicin, topotecan, idarubicin, TAS.103, etoposide, rubitecan, mitoxantrone, dexrazoxane, amsacrine, exatecan.mesylate, SN.38, genz.644282, camptothecin, irinotecan",0.756961951313706,0.397940008672038,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.65453,-1.55,0.051,1068,0.245,"albendazole, flubendazole, vincristine, fenbendazole, ABT.751, CYT.997, epothilone.d, podophyllotoxin, BNC105, nocodazole, dolastatin.10, vinorelbine, plinabulin, indibulin, mebendazole, epothilone.b, parbendazole, fosbretabulin, paclitaxel, docetaxel",1.29242982390206,0.610833915635468,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.57025,-1.37,0.118,1293,0.404,"NVP.TAE226, sorafenib, BMS.599626, aminopurvalanol.a, CP.724714, vandetanib, dasatinib, tivantinib, AV.412",0.928117992693875,0.393618634889395,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.53907,-1.28,0.188,984,0.397,"sunitinib, OSI.930, MK.2461, PD.173074, dovitinib, linifanib, ENMD.2076, TG.100572, lenvatinib, golvatinib, cabozantinib, axitinib, foretinib, sorafenib, lucitanib, tivozanib, ZM.306416, AEE788, vandetanib, BMS.690514, XL.647",0.72584215073632,0.401209493236885,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",0.19292,0.544,0.945,1170,0.964,"doxercalciferol, tacalcitol, alfacalcidol, paricalcitol, calcitriol, ercalcitriol, maxacalcitol",0.0245681914907371,0.0159229660971692,FALSE
+"H1650","Pearson.est","EGFR inhibitor",-0.54931,-1.61,0.0588,1198,0.294,"ARRY.334543, BMS.599626, FERb.033, gefitinib, neratinib, PD.153035, brigatinib, tyrphostin.AG.494, poziotinib, afatinib, AZD8931, WZ8040, WZ.4002, dacomitinib, pelitinib, BIBU.1361, vandetanib, erlotinib, icotinib, lapatinib, osimertinib, PD.168393, XL.647, BMS.690514, canertinib",1.23062267392386,0.531652669587843,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",-0.36567,-1.05,0.374,1268,0.728,"ponatinib, bosutinib, ZM.306416, dasatinib",0.42712839779952,0.137868620686963,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.40273,0.968,0.507,455,0.838,"xanomeline, tremorine, oxiracetam",0.294992040666664,0.0767559813697235,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.73677,-2.08,0.00976,1305,0.095,"iododexetimide, hyoscyamine, dicycloverine",2.01055018233331,1.02227639471115,TRUE
+"H1650","Pearson.est","adenosine receptor antagonist",0.40564,0.96,0.549,581,0.83,"SCH.58261, sulmazole, PSB.1115, istradefylline, MRS.1220",0.260427655549908,0.0809219076239261,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.34497,-0.941,0.513,1310,0.811,"oxymetazoline, xylazine, ritodrine, isoetharine, midodrine, isoxsuprine",0.289882634888184,0.090979145788844,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.3147,0.755,0.779,389,0.971,"carvedilol, oxprenolol, atipamezole, atenolol......, dihydroergocristine, idazoxan",0.108462542327436,0.0127807700919951,FALSE
+"H1650","Pearson.est","AKT inhibitor",0.32673,0.779,0.734,572,0.959,"uprosertib, GDC.0068, A.674563, ONC201, MK.2206",0.134303940083929,0.0181813928293364,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34001,-0.997,0.427,1255,0.739,"AP26113, brigatinib, lorlatinib, GW.788388",0.369572124974976,0.131355561605174,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.68867,-2.03,0,1102,0.0857,"cyproterone.acetate, flutamide, bicalutamide, RU.58841",Inf,1.0670191780768,TRUE
+"H1650","Pearson.est","antioxidant",-0.43481,-1.26,0.187,627,0.547,"taurine, mesna, chlorogenic.acid, rutin, trolox, benfotiamine",0.728158393463501,0.262012673666569,FALSE
+"H1650","Pearson.est","AP inhibitor",0.30252,0.71,0.828,673,1,"idronoxil, tanshinone.i, birinapant",0.0819696632151199,0,FALSE
+"H1650","Pearson.est","ATPase inhibitor",0.66106,1.57,0.0373,139,0.216,"NMS.873, evodiamine, oligomycin.a, digoxin, thonzonium",1.42829116819131,0.665546248849069,TRUE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.6765,1.6,0.0295,446,0.262,"danusertib, TAK.901, barasertib.HQPA, PHA.680632, barasertib, SNS.314, CCT137690, AMG900, GSK1070916, MK.5108, KW.2449, alisertib, aurora.a.inhibitor.i, CCT129202, MK.8745, tozasertib, AT.9283, ENMD.2076, ZM.447439, hesperadin, CYC116",1.53017798402184,0.581698708680255,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30536,-0.873,0.574,1415,0.765,"dirithromycin",0.241088107602027,0.116338564846382,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.26145,0.623,0.904,677,0.981,"trovafloxacin, lomefloxacin, novobiocin, nadifloxacin",0.0438315695246367,0.0083309926200515,FALSE
+"H1650","Pearson.est","BCL inhibitor",0.2884,0.684,0.851,63,0.979,"TW.37",0.0700704399154121,0.00921730819686218,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",-0.37112,-1.12,0.259,1268,0.642,"ponatinib, bosutinib, dasatinib",0.586700235918748,0.192464971931147,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",-0.23066,-0.682,0.844,331,0.889,"bentazepam, ZK.93423, piperazine, zaleplon, nefiracetam, indiplon, CL.218872, gamma.aminobutyric.acid, lorazepam, ivermectin, temazepam, CGS.20625, eprinomectin",0.073657553374345,0.0510982390297863,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.84397,1.99,0,231,0.0297,"OTX015, JQ1...., bromosporine, I.BET151, I.BET.762, PFI.1",Inf,1.52724355068279,TRUE
+"H1650","Pearson.est","calcium channel blocker",0.33712,0.805,0.738,623,0.984,"carboxyamidotriazole, tetrandrine, penfluridol, mibefradil, pranidipine, cinnarazine",0.131943638176958,0.00700490156865849,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",0.50737,1.2,0.236,451,0.553,"SB.225002, RS.504393, PF.04136309, UNBS.5162",0.627087997029893,0.257274868695302,FALSE
+"H1650","Pearson.est","CDK inhibitor",0.51548,1.23,0.204,539,0.531,"indisulam, BMS.387032, dinaciclib, arcyriaflavin.a, JNJ.7706621, PHA.793887, abemaciclib, indirubin, PHA.848125, P276.00, palbociclib, aminopurvalanol.a, AT.7519, TG.02, R547, BMS.265246",0.690369832574101,0.274905478918531,FALSE
+"H1650","Pearson.est","CHK inhibitor",0.37845,0.888,0.611,302,0.954,"SB.218078, PF.477736",0.213958789757446,0.0204516252959049,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",0.17886,0.426,0.988,502,0.994,"piroxicam, sulfasalazine, meloxicam, FR.122047, amfenac, suxibuzone, ramifenazone",0.00524305541237188,0.00261361560268669,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",-0.53336,-1.54,0.0761,1279,0.316,"eplerenone, clotrimazole, metyrapone",1.11861534322943,0.500312917381596,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.56164,1.34,0.149,475,0.465,"mitomycin.c, satraplatin, estramustine, carmustine, cisplatin, dianhydrogalactitol, melphalan, TH.302",0.826813731587726,0.332547047110046,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.35751,0.845,0.664,172,0.985,"valrubicin, chlorambucil, pibenzimol, oxaliplatin",0.177831920631982,0.00656376950238827,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.56059,1.33,0.145,470,0.434,"fdcyd, disulfiram, SGI.1027, decitabine",0.838631997765025,0.362510270487489,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",0.52097,1.23,0.222,482,0.531,"cephalomannine, idoxuridine, trifluridine, adefovir.dipivoxil",0.653647025549361,0.274905478918531,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",0.42102,0.994,0.489,399,0.804,"floxuridine, cyclocytidine, mitomycin.c, anisomycin, cisplatin, enocitabine",0.31069114087638,0.0947439512515487,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",-0.17648,-0.51,0.988,1254,0.982,"clebopride, oxiperomide, remoxipride, ziprasidone",0.00524305541237188,0.00788851221305034,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",-0.30406,-0.899,0.557,1402,0.798,"equol",0.254144804826271,0.0979971086492706,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",-0.2972,-0.842,0.617,1413,0.782,"raloxifene",0.209714835966758,0.106793246940152,FALSE
+"H1650","Pearson.est","FGFR inhibitor",0.5928,1.41,0.0903,357,0.402,"dovitinib, regorafenib, erdafitinib, nintedanib, PD.173074",1.04431224968649,0.39577394691553,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.54129,1.27,0.172,512,0.489,"dovitinib, lestaurtinib, TG.101348, KW.2449, pacritinib, tyrphostin.AG.1296, tozasertib, ENMD.2076, GTP.14564, sorafenib, TG.02",0.764471553092451,0.31069114087638,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",-0.28599,-0.807,0.668,1339,0.81,"fluocinolone.acetonide, prednisolone.acetate, hydrocortisone",0.175223537524454,0.0915149811213502,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",0.26338,0.622,0.91,194,0.964,"ACDPP, felbamate",0.0409586076789064,0.0159229660971692,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.25884,0.609,0.923,60,0.957,"AZD2858",0.0347982989740879,0.0190880622231565,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.63447,1.51,0.047,421,0.288,"danusertib, lestaurtinib, GSK1838705A, AZD3463, PHA.848125",1.32790214206428,0.540607512240769,FALSE
+"H1650","Pearson.est","HCV inhibitor",0.36008,0.837,0.67,176,0.976,"mericitabine",0.173925197299174,0.0105501823333082,FALSE
+"H1650","Pearson.est","HDAC inhibitor",0.67571,1.59,0.0338,381,0.241,"M.344, resminostat, PCI.24781, R306465, trichostatin.a, givinostat, NSC.3852, SB.939, AR.42, dacinostat, pyroxamide, nexturastat.a, belinostat, scriptaid, ACY.1215, chidamide, entinostat, vorinostat, panobinostat, RGFP966",1.47108329972235,0.617982957425132,TRUE
+"H1650","Pearson.est","histamine receptor antagonist",-0.25758,-0.728,0.76,1229,0.903,"cimetidine, zolantidine, lafutidine, terfenadine, ranitidine, famotidine, chloropyramine",0.119186407719209,0.0443122496864942,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.49704,-1.43,0.125,1277,0.398,"pitavastatin, lovastatin, simvastatin",0.903089986991944,0.400116927926312,FALSE
+"H1650","Pearson.est","HSP inhibitor",0.33506,0.794,0.742,592,0.978,"NMS.E973, SNX.2112, SNX.5422, PU.H71, KW.2478, BIIB021",0.129596094720973,0.00966114521239857,FALSE
+"H1650","Pearson.est","JAK inhibitor",0.51186,1.21,0.242,423,0.553,"WHI.P154, lestaurtinib, AZ960, TG.101348, TG.101209, pacritinib, tozasertib, AT.9283, baricitinib",0.616184634019569,0.257274868695302,FALSE
+"H1650","Pearson.est","KIT inhibitor",0.33804,0.789,0.756,201,0.964,"OSI.930, regorafenib, pazopanib",0.121478204498793,0.0159229660971692,FALSE
+"H1650","Pearson.est","MDM inhibitor",-0.31068,-0.889,0.55,448,0.775,"serdemetan, idasanutlin, nutlin.3, AMG.232, RITA, CGM097",0.259637310505756,0.11069829749369,FALSE
+"H1650","Pearson.est","MEK inhibitor",0.426,1.01,0.452,712,0.817,"PD.198306, MEK162, selumetinib, PD.318088, PD.0325901, PD.98059, U.0126, trametinib, Ro.4987655, AS.703026, AZD8330, cobimetinib, arctigenin, TAK.733",0.344861565188618,0.0877779434675845,FALSE
+"H1650","Pearson.est","MET inhibitor",0.60259,1.42,0.0902,291,0.413,"PHA.665752, AMG458, NVP.BVU972",1.04479346245806,0.384049948343599,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.55804,1.35,0.13,313,0.473,"D.64131, vinflunine, vinblastine, triclabendazole, cabazitaxel",0.886056647693163,0.325138859262188,FALSE
+"H1650","Pearson.est","mTOR inhibitor",0.29581,0.703,0.851,538,0.998,"GSK2126458, PF.04691502, PI.103, deforolimus, PKI.179, ku.0063794, AZD2014, OSI.027, PP242, AZD8055, PF.05212384",0.0700704399154121,0.000869458712628891,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",0.44286,1.04,0.446,652,0.827,"EVP4593, parthenolide, BAY.11.7082, betulinic.acid, Ro.106.9920, parthenolide...., curcumin, bindarit",0.350665141287858,0.0824944904474534,FALSE
+"H1650","Pearson.est","opioid receptor agonist",-0.31711,-0.907,0.526,1285,0.828,"BW.180C, ADL5859, cebranopadol",0.279014255846261,0.0819696632151199,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.45445,1.08,0.38,69,0.784,"talmapimod",0.42021640338319,0.105683937315562,FALSE
+"H1650","Pearson.est","PARP inhibitor",0.67308,1.57,0.0272,335,0.216,"talazoparib, niraparib, olaparib, PJ.34, AZD2461",1.5654310959658,0.665546248849069,TRUE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.27382,0.649,0.869,282,0.996,"dovitinib, regorafenib, axitinib, pazopanib, nintedanib",0.0609802235513335,0.00174066157630127,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",0.42984,1,0.496,631,0.816,"alexidine, CID.5458317, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., mycophenolate.mofetil, GSK2830371, menadione",0.304518323509803,0.0883098412461389,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",-0.33727,-1,0.425,485,0.785,"enoximone, cilostamide, zardaverine, anagrelide, avanafil, EMD.53998, papaverine, GSK256066, YM.976, trequinsin",0.371611069949688,0.105130343254747,FALSE
+"H1650","Pearson.est","PI3K inhibitor",0.42922,1.02,0.45,690,0.82,"CUDC.907, GSK2126458, PF.04691502, buparlisib, PI.103, AZD6482, PKI.179, taselisib, PIK.75, alpelisib, GDC.0941, ZSTK.474, BGT226, CH5132799, pilaralisib, PF.05212384, YM.201636, SB.2343, TG.100713, idelalisib, PI3K.IN.2, voxtalisib",0.346787486224656,0.0861861476162833,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.80299,1.87,0.00498,56,0.0722,"BI.2536, volasertib, NMS.1286937, GW.843682X, rigosertib",2.30277065724028,1.14146280243036,TRUE
+"H1650","Pearson.est","potassium channel blocker",-0.3828,-1.15,0.297,552,0.633,"dofetilide, mepivacaine, ML133, ibutilide, oleoylethanolamide, meglitinide",0.527243550682788,0.198596289982645,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",0.2374,0.564,0.942,578,0.969,"ciprofibrate, clofibrate, GW.501516",0.0259490972071227,0.0136762229492347,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",0.37721,0.878,0.644,684,0.948,"tanaproget, dienogest, norgestrel, danazol, nomegestrol.acetate, norethindrone",0.191114132640188,0.0231916626619338,FALSE
+"H1650","Pearson.est","proteasome inhibitor",-0.24792,-0.701,0.822,357,0.903,"MG.132, ONX.0914, delanzomib, carfilzomib, bortezomib, ixazomib, oprozomib, ixazomib.citrate",0.0851281824599496,0.0443122496864942,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.6642,1.6,0.0271,343,0.262,"anguidine, homoharringtonine, bruceantin, tedizolid.phosphate, harringtonine, azomycin..2.nitroimidazole., thiostrepton, clofoctol, cycloheximide, puromycin, emetine",1.56703070912559,0.581698708680255,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.44188,1.05,0.405,429,0.831,"tyrphostin.A9, mubritinib, NVP.TAE226, PP.121, CP.724714",0.392544976785331,0.080398976215889,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.67913,1.6,0.0211,286,0.262,"TAK.632, GDC.0879, regorafenib, SB.590885, AZ.628, RAF265, dabrafenib, PLX.4720, CEP.32496",1.67571754470231,0.581698708680255,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.29413,0.691,0.82,79,0.992,"regorafenib",0.0861861476162833,0.00348832784582135,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.5364,1.28,0.168,532,0.491,"adarotene, adapalene, fenretinide, AM.580, bexarotene",0.774690718274137,0.308918507877032,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.57151,1.36,0.126,554,0.482,"clofarabine, LY2334737, fludarabine.phosphate, pentostatin, triapine, fludarabine, hydroxyurea, gemcitabine",0.899629454882437,0.31695296176115,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",0.46256,1.1,0.317,1,0.76,"aripiprazole",0.498940737782249,0.119186407719209,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",0.55302,1.33,0.141,422,0.434,"aripiprazole, SB.200646, sertindole, pirenperone, lurasidone, lerisetron",0.85078088734462,0.362510270487489,FALSE
+"H1650","Pearson.est","sodium channel blocker",0.43239,1.02,0.432,653,0.82,"brivaracetam, benzethonium, lappaconite, cibenzoline, butamben, mexiletine, triamterene, ajmaline, quinidine, mepivacaine",0.364516253185088,0.0861861476162833,FALSE
+"H1650","Pearson.est","src inhibitor",-0.58628,-1.67,0.0319,1407,0.29,"ZM.306416, saracatinib, dasatinib",1.49620931694282,0.537602002101044,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",-0.44502,-1.3,0.162,1275,0.542,"sulconazole, ketoconazole, terconazole, lanoconazole",0.790484985457369,0.266000713461613,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.44969,-1.22,0.217,1188,0.561,"LY2109761, SB.431542, repsox",0.66354026615147,0.251037138743839,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.56056,1.31,0.141,371,0.451,"doxifluridine, raltitrexed, trifluridine, carmofur",0.85078088734462,0.345823458122039,FALSE
+"H1650","Pearson.est","topoisomerase inhibitor",0.64315,1.49,0.0688,397,0.294,"doxorubicin, valrubicin, epirubicin, teniposide, voreloxin, amsacrine, daunorubicin, dexrazoxane, etoposide.phosphate, etoposide, mitoxantrone, idarubicin, topotecan, nemorubicin, TAS.103, amonafide, genz.644282, SN.38, irinotecan, exatecan.mesylate",1.16241156176449,0.531652669587843,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.70647,1.68,0.0145,363,0.29,"fosbretabulin, taltobulin, vinorelbine, vindesine, KX2.391, fenbendazole, parbendazole, albendazole, vincristine, nocodazole, vinblastine, flubendazole, ABT.751, paclitaxel, verubulin, BNC105, indibulin, combretastatin.A.4, dolastatin.10, plinabulin, CYT.997, epothilone.b, docetaxel, oxibendazole",1.83863199776503,0.537602002101044,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.34384,0.816,0.695,478,0.989,"regorafenib, UNC2250, tivantinib, tyrphostin.A9, mubritinib, NVP.TAE226, PP.121, bafetinib, tyrphostin.AG.99, CP.724714, GTP.14564, sorafenib, aminopurvalanol.a",0.158015195409886,0.0048037084028206,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.26944,0.644,0.907,419,0.981,"OSI.930, dovitinib, regorafenib, RAF265, axitinib, pazopanib, semaxanib, nintedanib, PD.173074, SAR131675, ENMD.2076",0.0423927129399047,0.0083309926200515,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.72905,-2.08,0,1156,0.095,"ercalcitriol, maxacalcitol, alfacalcidol, paricalcitol, doxercalciferol",Inf,1.02227639471115,TRUE
+"H1975","Pearson.est","EGFR inhibitor",0.82838,2.01,0,88,0.0404,"poziotinib, afatinib, AZD8931, neratinib, tucatinib, dacomitinib, canertinib, osimertinib, BMS.690514, pelitinib, CUDC.101, lapatinib, CP.724714, ARRY.334543, BMS.599626, AST.1306, BIBX.1382, AEE788, gefitinib, erlotinib, rociletinib, TAK.285, XL.647, CNX.2006, PD.168393, GW.583340, WZ.4002",Inf,1.3936186348894,TRUE
+"H1975","Pearson.est","Abl kinase inhibitor",0.28732,0.729,0.769,257,1,"ZM.306416, bosutinib, imatinib",0.114073660198569,0,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",-0.46045,-1.21,0.237,1252,0.556,"nefiracetam, nicotine",0.625251653989896,0.254925208417942,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",-0.66193,-1.68,0.0393,1067,0.176,"hyoscyamine, methscopolamine, iododexetimide, dicycloverine",1.40560744962457,0.75448733218585,TRUE
+"H1975","Pearson.est","adenosine receptor antagonist",0.57734,1.42,0.116,224,0.361,"CGS.15943, MRS.1220, SCH.58261",0.935542010773082,0.442492798094342,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",0.18387,0.475,0.988,272,1,"lidamidine, metaraminol, A61603",0.00524305541237188,0,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",-0.36797,-0.946,0.518,1377,0.709,"metoprolol, atenolol...., levobunolol",0.285670240254767,0.149353764816933,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.5968,1.47,0.0917,313,0.366,"uprosertib, GDC.0068, A.674563, triciribine, CCT128930, GSK2110183, AZD5363",1.03763066432998,0.436518914605589,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33128,0.82,0.668,477,0.959,"AZD3463, crizotinib, AP26113, NVP.TAE684, brigatinib, SB.505124, CEP.37440",0.175223537524454,0.0181813928293364,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",-0.6156,-1.6,0.0763,1086,0.234,"cyproterone.acetate, flutamide, nilutamide, bicalutamide",1.11747546204512,0.630784142589857,FALSE
+"H1975","Pearson.est","antioxidant",-0.75324,-1.96,0.0118,1089,0.0679,"chlorogenic.acid, taurine, mesna, benfotiamine, trolox",1.92811799269387,1.1681302257195,TRUE
+"H1975","Pearson.est","AP inhibitor",-0.47985,-1.24,0.227,1131,0.543,"embelin, idronoxil, LCL.161, GDC.0152",0.643974142806877,0.265200170411153,FALSE
+"H1975","Pearson.est","ATPase inhibitor",0.24677,0.609,0.915,90,1,"k.strophanthidin, NMS.873",0.0385789059335517,0,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",0.59561,1.5,0.0872,397,0.383,"PHA.680632, TAK.901, danusertib, aurora.a.inhibitor.i, CCT137690, barasertib, CCT129202, GSK1070916, ENMD.2076, CYC116, barasertib.HQPA, ZM.447439",1.05948351506743,0.416801226031377,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.371,0.942,0.504,370,0.905,"azithromycin, azalomycin.b, tedizolid",0.297569463554475,0.0433514207947967,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.26078,-0.674,0.858,1345,0.899,"sparfloxacin",0.0665127121512946,0.0462403082667712,FALSE
+"H1975","Pearson.est","BCL inhibitor",-0.29114,-0.744,0.759,1082,0.88,"ABT.737, gossypol, venetoclax",0.11975822410452,0.0555173278498314,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.40485,-1.04,0.411,1205,0.688,"dasatinib, flumatinib, nilotinib, ponatinib",0.386158178123931,0.162411561764489,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",-0.32425,-0.847,0.619,1252,0.825,"nefiracetam, CGS.20625, lorazepam",0.208309350979882,0.0835460514500749,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",0.80793,2.02,0.00189,151,0.0739,"I.BET151, OTX015, JQ1...., PFI.1",2.72353819582676,1.13135556160517,TRUE
+"H1975","Pearson.est","calcium channel blocker",0.35786,0.895,0.574,268,0.907,"SR.33805, tetrandrine, fendiline",0.241088107602027,0.0423927129399047,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",0.48945,1.19,0.266,518,0.669,"ZK811752, RS.504393, PF.04136309, SB.225002, UNBS.5162",0.575118363368933,0.174573882232177,FALSE
+"H1975","Pearson.est","CDK inhibitor",0.34675,0.874,0.604,299,0.887,"indisulam, arcyriaflavin.a, BMS.387032, aminopurvalanol.a, PHA.793887, AT.7519, TG.02",0.218963061378868,0.0520763801682736,FALSE
+"H1975","Pearson.est","CHK inhibitor",0.27227,0.685,0.863,347,1,"PF.477736, CHIR.124, SB.218078",0.0639892042847904,0,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",0.23137,0.579,0.942,430,1,"ramifenazone, phenazone, pterostilbene, FR.122047, tryptanthrin, amfenac, AM.404, aspirin, meloxicam",0.0259490972071227,0,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.79362,-2.02,0.00444,1229,0.0606,"PF.4981517, cobicistat, morin, clotrimazole, eplerenone, metyrapone",2.35261702988538,1.21752737583371,TRUE
+"H1975","Pearson.est","DNA alkylating agent",0.28129,0.697,0.839,204,1,"dacarbazine, mitomycin.c, satraplatin, estramustine",0.0762380391712997,0,FALSE
+"H1975","Pearson.est","DNA inhibitor",-0.36787,-0.965,0.5,1163,0.732,"metronidazole, sangivamycin, pibenzimol, carmustine, carboplatin",0.301029995663981,0.135488918941608,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.64463,1.59,0.0548,175,0.341,"SGI.1027, decitabine, fdcyd, azacitidine",1.26121944151563,0.467245621007502,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",0.40126,0.981,0.472,128,0.893,"cephalomannine, cidofovir",0.326058001365912,0.0491485411114536,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",-0.29204,-0.756,0.723,926,0.888,"cyclocytidine, capecitabine, cisplatin, artesunate, artemisinin, azodicarbonamide, CB.10.277, estramustine.phosphate, altretamine, nelarabine",0.140861702705469,0.051587034221399,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",-0.38458,-0.998,0.427,1143,0.702,"nemonapride, UH.232...., paliperidone, isofloxythepin, amisulpride, raclopride",0.369572124974976,0.153662887870195,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.42262,-1.05,0.359,1038,0.703,"equol, PPT, estradiol.cypionate, estradiol",0.444905551421681,0.153044674980176,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",0.37583,0.937,0.524,515,0.882,"clomifene, tamoxifen, danazol",0.280668713016273,0.0545314148681803,FALSE
+"H1975","Pearson.est","FGFR inhibitor",-0.19439,-0.49,0.971,976,0.983,"MK.2461, AZD4547, erdafitinib, orantinib",0.0127807700919951,0.00744648216786438,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",0.24811,0.617,0.91,442,1,"pacritinib, sorafenib, TG.02, ENMD.2076, lestaurtinib, tyrphostin.AG.1296, dovitinib",0.0409586076789064,0,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",-0.26524,-0.68,0.834,1161,0.918,"flumethasone.pivalate, prednisolone.hemisuccinate, dexamethasone.acetate, hydrocortisone, fluocinolone.acetonide, fluticasone.propionate, piretanide",0.0788339493622613,0.0371573187987575,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",0.13612,0.337,1,558,1,"CGP.37849, tiletamine, ACDPP, felbamate, LY456236, CPP",0,0,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.52838,-1.34,0.172,1316,0.494,"CHIR.99021, tideglusib, CHIR.98014",0.764471553092451,0.306273051076353,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",0.58961,1.48,0.105,474,0.384,"danusertib, AZD3463, lestaurtinib, GSK1838705A, GW.441756",0.978810700930062,0.415668775632469,FALSE
+"H1975","Pearson.est","HCV inhibitor",-0.30711,-0.791,0.727,1131,0.893,"embelin, Ro.9187",0.138465589140962,0.0491485411114536,FALSE
+"H1975","Pearson.est","HDAC inhibitor",0.65305,1.65,0.0335,373,0.281,"PCI.24781, SB.939, givinostat, M.344, trichostatin.a, vorinostat, AR.42, scriptaid, R306465, chidamide, JNJ.26481585, dacinostat, pyroxamide, belinostat, tacedinaline, NSC.3852, resminostat, panobinostat",1.47495519296315,0.55129368009492,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",-0.20588,-0.539,0.964,977,0.992,"ICI.162846, famotidine, pheniramine, cimetidine, tiotidine, BF2.649, nizatidine, chloropyramine, lafutidine",0.0159229660971692,0.00348832784582135,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.88112,-2.35,0,1303,0,"simvastatin, atorvastatin, fluvastatin, mevastatin, pitavastatin",Inf,Inf,TRUE
+"H1975","Pearson.est","HSP inhibitor",0.58885,1.42,0.12,250,0.361,"tanespimycin, KW.2478, BIIB021, VER.49009, alvespimycin",0.920818753952375,0.442492798094342,FALSE
+"H1975","Pearson.est","JAK inhibitor",0.39335,0.957,0.488,628,0.907,"LY2784544, pacritinib, CEP.33779, TG.02, WHI.P154, lestaurtinib, AZD1480, TG.101348, baricitinib, ruxolitinib, PRT062070, TG.101209",0.311580177997289,0.0423927129399047,FALSE
+"H1975","Pearson.est","KIT inhibitor",0.19981,0.493,0.976,257,1,"OSI.930, sorafenib, imatinib",0.0105501823333082,0,FALSE
+"H1975","Pearson.est","MDM inhibitor",-0.73553,-1.88,0.0166,1348,0.0806,"CGM097, nutlin.3, AMG.232, idasanutlin",1.77989191195995,1.09366495819491,TRUE
+"H1975","Pearson.est","MEK inhibitor",0.20079,0.492,0.985,653,1,"PD.198306, PD.98059, PD.0325901, trametinib, TAK.733, Ro.4987655, MEK162, AS.703026, AZD8330, selumetinib, MEK1.2.inhibitor, PD.184352",0.00656376950238827,0,FALSE
+"H1975","Pearson.est","MET inhibitor",0.46069,1.12,0.326,316,0.74,"INC.280, NVP.BVU972, AMG458",0.486782399932061,0.130768280269024,FALSE
+"H1975","Pearson.est","microtubule inhibitor",-0.29117,-0.738,0.759,1159,0.861,"vinblastine, estramustine.phosphate, secnidazole",0.11975822410452,0.0649968485463452,FALSE
+"H1975","Pearson.est","mTOR inhibitor",0.19739,0.482,0.974,555,1,"GSK2126458, PF.05212384, PKI.179, AZD8055, sirolimus, torin.2, PI.103, everolimus, voxtalisib, WYE.125132, PP242, deforolimus, GDC.0980, PF.04691502",0.0114410431213845,0,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",0.24686,0.62,0.9,505,1,"EVP4593, Ro.106.9920, parthenolide...., bindarit, tyloxapol",0.0457574905606751,0,FALSE
+"H1975","Pearson.est","opioid receptor agonist",-0.66214,-1.7,0.0278,1217,0.211,"spiradoline, BW.180C, cebranopadol",1.55595520408192,0.675717544702307,TRUE
+"H1975","Pearson.est","p38 MAPK inhibitor",0.62102,1.53,0.0585,339,0.368,"talmapimod, SB.239063, SB.242235, TAK.715",1.23284413391782,0.434152181326482,FALSE
+"H1975","Pearson.est","PARP inhibitor",0.3551,0.877,0.61,193,0.912,"PJ.34, niraparib",0.214670164989233,0.0400051616715838,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.34107,-0.884,0.605,1093,0.789,"telatinib, pazopanib, dasatinib, ponatinib, orantinib, KI.8751, SU014813, CP.673451",0.218244625347531,0.10292299679058,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",-0.50199,-1.29,0.192,1360,0.538,"bis.maltolato.oxovanadium.IV., BVT.948, GSK2830371",0.71669877129645,0.269217724333611,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",-0.41842,-1.08,0.363,1299,0.68,"YM.976, anagrelide, GSK256066",0.440093374963888,0.167491087293764,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.40705,1.01,0.426,221,0.866,"taselisib, alpelisib, CH5132799, CUDC.907, GSK2126458, PF.05212384, PIK.75, GDC.0941",0.370590400897281,0.0624821079826534,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.75172,1.87,0.0054,201,0.0698,"BI.2536, NMS.1286937, HMN.214, volasertib",2.26760624017703,1.15614457737684,TRUE
+"H1975","Pearson.est","potassium channel blocker",-0.63988,-1.68,0.035,1233,0.176,"ibutilide, meglitinide, mepivacaine",1.45593195564972,0.75448733218585,TRUE
+"H1975","Pearson.est","PPAR receptor agonist",-0.36532,-0.949,0.513,1314,0.732,"clofibrate, fenofibrate",0.289882634888184,0.135488918941608,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.52475,-1.39,0.131,1202,0.498,"norgestrel, norethindrone.acetate, norethindrone",0.882728704344236,0.302770657240282,FALSE
+"H1975","Pearson.est","proteasome inhibitor",-0.48543,-1.28,0.181,1048,0.515,"bortezomib, ixazomib, MG.132, oprozomib, ixazomib.citrate",0.742321425130815,0.288192770958809,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.52566,1.28,0.199,216,0.532,"bruceantin, anguidine, homoharringtonine, thiostrepton, tedizolid.phosphate, puromycin, clofoctol, cycloheximide",0.701146923590293,0.274088367704952,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.77353,1.91,0.00678,228,0.0825,"CP.724714, BMS.599626, AV.412, tyrphostin.A9, mubritinib, NVP.TAE226",2.16877030613294,1.08354605145007,TRUE
+"H1975","Pearson.est","RAF inhibitor",-0.4286,-1.11,0.329,1265,0.66,"LGX818, dabrafenib, vemurafenib",0.482804102050026,0.180456064458131,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.45105,1.1,0.346,202,0.746,"vandetanib, sorafenib",0.460923901207223,0.127261172527331,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.59722,1.45,0.111,341,0.37,"adarotene, tamibarotene, fenretinide, CD.437, bexarotene, adapalene",0.954677021213343,0.431798275933005,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.52379,-1.34,0.173,937,0.494,"fludarabine, pentostatin, cytarabine, gemcitabine, hydroxyurea, triapine, clofarabine, cladribine",0.761953896871205,0.306273051076353,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.72293,-1.92,0.00939,1407,0.0748,"ipsapirone, SR.57227A",2.02733440773389,1.12609840213554,TRUE
+"H1975","Pearson.est","serotonin receptor antagonist",0.28969,0.707,0.809,223,1,"SB.200646, lurasidone, SB.228357",0.0920514783877277,0,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.3868,-1,0.421,1187,0.729,"quinidine, mepivacaine, butamben, cibenzoline, oxcarbazepine",0.375717904164332,0.137272471682025,FALSE
+"H1975","Pearson.est","src inhibitor",0.45394,1.14,0.303,303,0.736,"ZM.306416, saracatinib, bosutinib, KX2.391",0.518557371497695,0.133122185662501,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",-0.43594,-1.13,0.323,1085,0.66,"ketoconazole, terconazole, sulconazole",0.490797477668897,0.180456064458131,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",-0.29958,-0.781,0.702,432,0.879,"repsox, D.4476, SB.431542, adaprev, SB.525334, LY2109761",0.153662887870195,0.0560111249262281,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.28988,0.725,0.804,1030,1,"carmofur, raltitrexed, trifluridine, doxifluridine, capecitabine, ftorafur",0.0947439512515487,0,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",0.42143,1.06,0.357,499,0.799,"amonafide, exatecan.mesylate, camptothecin, irinotecan, amsacrine, genz.644282, valrubicin, mitoxantrone, SN.38, idarubicin, teniposide, daunorubicin, doxorubicin",0.447331783887807,0.0974532206860086,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",0.54913,1.38,0.12,317,0.397,"nocodazole, albendazole, fosbretabulin, parbendazole, fenbendazole, plinabulin, indibulin, paclitaxel, vinorelbine, mebendazole, vincristine, KX2.391, docetaxel, dolastatin.10, oxibendazole",0.920818753952375,0.401209493236885,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",0.61601,1.53,0.0929,228,0.368,"CP.724714, BMS.599626, AV.412, tivantinib, tyrphostin.A9, mubritinib, vandetanib, aminopurvalanol.a, sorafenib, NVP.TAE226",1.03198428600636,0.434152181326482,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",0.36187,0.898,0.574,471,0.933,"BMS.690514, AEE788, ZM.306416, OSI.930, XL.647, vandetanib, sorafenib, PD.173074, ENMD.2076, tivozanib, axitinib, foretinib, dovitinib, TG.100572, regorafenib, golvatinib, vatalanib",0.241088107602027,0.0301183562535,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.75925,1.9,0.00693,264,0.0678,"maxacalcitol, tacalcitol, calcitriol, ercalcitriol, paricalcitol",2.15926676538819,1.16877030613294,TRUE
+"H2009","Pearson.est","EGFR inhibitor",-0.85853,-2.14,0,1319,0.0146,"GW.583340, PD.153035, WZ8040, CUDC.101, AEE788, BIBX.1382, brigatinib, BMS.599626, WZ.4002, BIBU.1361, icotinib, AST.1306, TAK.285, CP.724714, rociletinib, PD.168393, tucatinib, gefitinib, ARRY.334543, vandetanib, lapatinib, XL.647, erlotinib, neratinib, BMS.690514, dacomitinib, osimertinib, AZD8931, pelitinib, poziotinib, canertinib, afatinib",Inf,1.83564714421556,TRUE
+"H2009","Pearson.est","Abl kinase inhibitor",-0.57232,-1.37,0.147,1408,0.471,"dasatinib, ZM.306416, bosutinib",0.832682665251824,0.326979092871104,FALSE
+"H2009","Pearson.est","acetylcholine receptor agonist",0.4241,1.08,0.344,75,0.69,"nefiracetam, nicotine",0.46344155742847,0.161150909262745,FALSE
+"H2009","Pearson.est","acetylcholine receptor antagonist",0.68339,1.73,0.0234,409,0.194,"dicycloverine, iododexetimide, diphemanil, methscopolamine",1.63078414258986,0.712198270069774,TRUE
+"H2009","Pearson.est","adenosine receptor antagonist",-0.39966,-0.982,0.462,1429,0.75,"CGS.15943",0.335358024443874,0.1249387366083,FALSE
+"H2009","Pearson.est","adrenergic receptor agonist",-0.42,-1.03,0.407,1023,0.753,"metaraminol, lidamidine, A61603, clenbuterol, buphenine, epinephrine, isoxsuprine",0.39040559077478,0.123205023799299,FALSE
+"H2009","Pearson.est","adrenergic receptor antagonist",-0.23291,-0.577,0.941,1010,0.955,"naftidrofuryl, imiloxan, prazosin, propranolol, dronedarone, practolol, RS.17053, pindolol",0.0264103765727431,0.0199966284162537,FALSE
+"H2009","Pearson.est","AKT inhibitor",-0.39427,-0.966,0.468,1107,0.723,"CCT128930, A.674563, uprosertib, triciribine",0.329754146925876,0.140861702705469,FALSE
+"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.5675,-1.42,0.13,1171,0.421,"crizotinib, GW.788388, NVP.TAE684, AZD3463, AP26113, brigatinib",0.886056647693163,0.375717904164332,FALSE
+"H2009","Pearson.est","androgen receptor antagonist",0.32216,0.846,0.628,347,0.824,"nilutamide, RU.58841",0.202040356262804,0.0840727883028842,FALSE
+"H2009","Pearson.est","antioxidant",0.44778,1.12,0.33,283,0.683,"trolox, taurine",0.481486060122112,0.165579296318467,FALSE
+"H2009","Pearson.est","AP inhibitor",0.56126,1.44,0.113,157,0.518,"GDC.0152, idronoxil, LCL.161",0.94692155651658,0.285670240254767,FALSE
+"H2009","Pearson.est","ATPase inhibitor",0.34868,0.876,0.578,112,0.857,"digoxin, blebbistatin...., oligomycin.a",0.238072161579471,0.0670191780768018,FALSE
+"H2009","Pearson.est","Aurora kinase inhibitor",-0.4014,-1,0.454,972,0.777,"PF.03814735, alisertib, KW.2449, ZM.447439, CYC116, hesperadin, TAK.901, danusertib, PHA.680632, aurora.a.inhibitor.i, GSK1070916, MLN.8054",0.342944147142896,0.109578981199086,FALSE
+"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.49043,-1.24,0.241,1120,0.598,"azalomycin.b, azithromycin, tedizolid",0.617982957425132,0.223298816011589,FALSE
+"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.20565,-0.505,0.977,1119,0.973,"lomefloxacin, finafloxacin",0.0101054362812269,0.0118871597316481,FALSE
+"H2009","Pearson.est","BCL inhibitor",0.48647,1.24,0.248,186,0.658,"ABT.737, gossypol, TW.37",0.605548319173784,0.181774106386044,FALSE
+"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.48573,-1.17,0.276,1408,0.659,"dasatinib, bosutinib",0.559090917934782,0.18111458540599,FALSE
+"H2009","Pearson.est","benzodiazepine receptor agonist",0.2133,0.544,0.963,515,0.982,"nefiracetam, lorazepam, CL.218872, zaleplon, indiplon, temazepam, eprinomectin",0.0163737128754655,0.00788851221305034,FALSE
+"H2009","Pearson.est","bromodomain inhibitor",0.49086,1.23,0.228,207,0.634,"bromosporine",0.642065152999546,0.197910742118267,FALSE
+"H2009","Pearson.est","calcium channel blocker",0.41574,1.06,0.389,156,0.694,"carboxyamidotriazole, mibefradil, pranidipine",0.410050398674292,0.158640529545145,FALSE
+"H2009","Pearson.est","CC chemokine receptor antagonist",0.22137,0.568,0.961,1129,1,"SB.225002, UNBS.5162, PF.04136309, MK.0812, RS.504393, navarixin, ZK811752",0.0172766123314547,0,FALSE
+"H2009","Pearson.est","CDK inhibitor",0.16,0.408,0.998,15,0.997,"abemaciclib",0.000869458712628891,0.00130484168834428,FALSE
+"H2009","Pearson.est","CHK inhibitor",-0.44925,-1.11,0.327,979,0.67,"PF.477736, LY2606368, CHIR.124, LY2603618",0.485452247339714,0.173925197299174,FALSE
+"H2009","Pearson.est","cyclooxygenase inhibitor",-0.40752,-0.995,0.445,1292,0.755,"ketoprofen, AM.404, phenazone, FK.3311, aspirin, ramifenazone",0.351639989019068,0.122053048370812,FALSE
+"H2009","Pearson.est","cytochrome P450 inhibitor",0.7995,2.01,0,277,0.0619,"metyrapone, cobicistat, clotrimazole, itraconazole, eplerenone, morin",Inf,1.20830935097988,TRUE
+"H2009","Pearson.est","DNA alkylating agent",0.31846,0.828,0.674,261,0.804,"carboplatin, TH.302, carmustine, temozolomide, streptozotocin, melphalan",0.17134010346468,0.0947439512515487,FALSE
+"H2009","Pearson.est","DNA inhibitor",0.49624,1.3,0.186,261,0.636,"pibenzimol, carboplatin, chlorambucil, carmustine, oxaliplatin, metronidazole, melphalan",0.730487055782084,0.196542884351586,FALSE
+"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.4607,-1.13,0.309,1351,0.702,"azacitidine, SGI.1027, decitabine",0.510041520575165,0.153662887870195,FALSE
+"H2009","Pearson.est","DNA polymerase inhibitor",-0.27401,-0.665,0.807,1397,0.941,"cephalomannine",0.0931264652779296,0.0264103765727431,FALSE
+"H2009","Pearson.est","DNA synthesis inhibitor",0.34516,0.897,0.533,331,0.914,"altretamine, artesunate, nelarabine, azodicarbonamide, cyclocytidine",0.273272790973428,0.0390538042661686,FALSE
+"H2009","Pearson.est","dopamine receptor antagonist",0.48243,1.21,0.267,324,0.593,"paliperidone, raclopride, nemonapride, isofloxythepin, amisulpride, remoxipride, domperidone",0.573488738635425,0.226945306635737,FALSE
+"H2009","Pearson.est","estrogen receptor agonist",-0.24614,-0.609,0.904,1365,0.976,"ethinyl.estradiol",0.0438315695246367,0.0105501823333082,FALSE
+"H2009","Pearson.est","estrogen receptor antagonist",0.21775,0.56,0.951,1134,0.998,"fulvestrant, danazol, toremifene, tamoxifen, raloxifene, clomifene",0.0218194830625861,0.000869458712628891,FALSE
+"H2009","Pearson.est","FGFR inhibitor",0.52991,1.39,0.138,179,0.564,"erdafitinib, orantinib, dovitinib",0.860120913598763,0.248720896016658,FALSE
+"H2009","Pearson.est","FLT3 inhibitor",0.33656,0.886,0.586,179,0.902,"TG.101348, GTP.14564, dovitinib",0.232102383981909,0.0447934624580583,FALSE
+"H2009","Pearson.est","glucocorticoid receptor agonist",0.41901,1.09,0.363,279,0.706,"dexamethasone.acetate, piretanide, prednisolone.hemisuccinate, halcinonide, triamcinolone, fluticasone.propionate, deflazacort, flumethasone.pivalate",0.440093374963888,0.151195298948196,FALSE
+"H2009","Pearson.est","glutamate receptor antagonist",0.32368,0.82,0.659,240,0.793,"MTPG, CPP, ACDPP",0.18111458540599,0.100726812682396,FALSE
+"H2009","Pearson.est","glycogen synthase kinase inhibitor",0.33159,0.858,0.632,483,0.83,"CHIR.98014, GSK.3.inhibitor.IX, CHIR.99021, indirubin, TWS.119",0.199282921717615,0.0809219076239261,FALSE
+"H2009","Pearson.est","growth factor receptor inhibitor",-0.59576,-1.45,0.103,1050,0.405,"lestaurtinib, GSK1838705A, danusertib, AZD3463",0.987162775294828,0.392544976785331,FALSE
+"H2009","Pearson.est","HCV inhibitor",0.47552,1.22,0.234,117,0.613,"Ro.9187, mericitabine",0.630784142589857,0.212539525481585,FALSE
+"H2009","Pearson.est","HDAC inhibitor",-0.5424,-1.34,0.155,1134,0.487,"givinostat, chidamide, AR.42, belinostat, tacedinaline, PCI.24781, SB.939, trichostatin.a, vorinostat, panobinostat, JNJ.26481585",0.809668301829709,0.312471038785366,FALSE
+"H2009","Pearson.est","histamine receptor antagonist",-0.34167,-0.849,0.622,1284,0.844,"levocetirizine, terfenadine, ranitidine, ebastine, zolantidine",0.206209615309181,0.073657553374345,FALSE
+"H2009","Pearson.est","HMGCR inhibitor",0.7293,1.82,0.0155,258,0.151,"mevastatin, fluvastatin, atorvastatin, pitavastatin",1.80966830182971,0.821023052706831,TRUE
+"H2009","Pearson.est","HSP inhibitor",-0.6319,-1.58,0.0557,1002,0.307,"guanidine, SNX.2112, ganetespib, NVP.AUY922, SNX.5422, XL888, alvespimycin, PU.H71, KW.2478, tanespimycin, BIIB021, VER.49009",1.25414480482627,0.512861624522813,FALSE
+"H2009","Pearson.est","JAK inhibitor",-0.45301,-1.12,0.318,1214,0.686,"AZD1480, WHI.P154, LY2784544, ruxolitinib, CEP.33779",0.497572880015567,0.163675884293248,FALSE
+"H2009","Pearson.est","KIT inhibitor",0.25702,0.655,0.864,383,0.958,"pazopanib, cediranib, KI.8751, telatinib, motesanib, sunitinib",0.0634862575211067,0.0186344909214556,FALSE
+"H2009","Pearson.est","MDM inhibitor",0.82381,2.12,0,97,0.0387,"idasanutlin, AMG.232, nutlin.3, CGM097",Inf,1.41228903498109,TRUE
+"H2009","Pearson.est","MEK inhibitor",-0.37827,-0.9,0.538,913,0.812,"PD.0325901, PD.198306, AS.703026, refametinib, MEK1.2.inhibitor, trametinib, PD.184352, AZD8330, PD.98059, TAK.733, Ro.4987655",0.269217724333611,0.0904439707588247,FALSE
+"H2009","Pearson.est","MET inhibitor",-0.71592,-1.74,0.0206,1361,0.189,"LY2801653, INC.280",1.68613277963085,0.723538195826756,TRUE
+"H2009","Pearson.est","microtubule inhibitor",-0.28182,-0.683,0.825,939,0.969,"colchicine, cytochalasin.b, D.64131, podophyllotoxin, cabazitaxel",0.0835460514500749,0.0136762229492347,FALSE
+"H2009","Pearson.est","mTOR inhibitor",-0.24386,-0.596,0.904,1158,0.963,"torin.2, deforolimus, everolimus, AZD8055, temsirolimus, GSK2126458, PF.05212384, sirolimus",0.0438315695246367,0.0163737128754655,FALSE
+"H2009","Pearson.est","NFkB pathway inhibitor",0.47912,1.25,0.229,299,0.688,"tyloxapol, BAY.11.7082, betulinic.acid, parthenolide...., parthenolide",0.640164517660112,0.162411561764489,FALSE
+"H2009","Pearson.est","opioid receptor agonist",0.33533,0.865,0.6,190,0.847,"cebranopadol, BW.180C",0.221848749616356,0.0721165896692931,FALSE
+"H2009","Pearson.est","p38 MAPK inhibitor",-0.68503,-1.66,0.0265,1208,0.264,"CMPD.1, SB.242235, TAK.715, SB.239063, talmapimod",1.57675412606319,0.578396073130169,FALSE
+"H2009","Pearson.est","PARP inhibitor",0.25625,0.665,0.857,1079,0.972,"AG.14361, endo.IWR.1, AZD2461, E7449, olaparib, niraparib, talazoparib, PJ.34",0.0670191780768018,0.0123337350737254,FALSE
+"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3746,0.97,0.491,508,0.803,"pazopanib, orantinib, SU014813, dovitinib, linifanib, KI.8751, axitinib, telatinib, motesanib, sunitinib, ponatinib, CP.673451, regorafenib, lenvatinib",0.308918507877032,0.095284454721319,FALSE
+"H2009","Pearson.est","phosphatase inhibitor",0.57569,1.45,0.0917,92,0.56,"GSK2830371, menadione, bis.maltolato.oxovanadium.IV.",1.03763066432998,0.2518119729938,FALSE
+"H2009","Pearson.est","phosphodiesterase inhibitor",-0.29278,-0.72,0.8,1317,0.945,"EMD.53998, papaverine",0.0969100130080564,0.0245681914907371,FALSE
+"H2009","Pearson.est","PI3K inhibitor",-0.27893,-0.679,0.823,1121,0.948,"PIK.75, CUDC.907, GDC.0941, GSK2126458, PF.05212384, PI.828, TG.100713, CH5132799, taselisib, alpelisib",0.0846001647877302,0.0231916626619338,FALSE
+"H2009","Pearson.est","PLK inhibitor",-0.72235,-1.77,0.0288,1373,0.188,"HMN.214, BI.2536, NMS.1286937",1.54060751224077,0.72584215073632,TRUE
+"H2009","Pearson.est","potassium channel blocker",0.3229,0.845,0.616,113,0.8,"mepivacaine",0.210419287835575,0.0969100130080564,FALSE
+"H2009","Pearson.est","PPAR receptor agonist",0.66616,1.68,0.0393,104,0.22,"clofibrate, fenofibrate, GW.501516",1.40560744962457,0.657577319177794,TRUE
+"H2009","Pearson.est","progesterone receptor agonist",0.40932,1.04,0.403,356,0.701,"norethindrone, norethindrone.acetate, norgestrel, tanaproget",0.39469495385889,0.154281982033341,FALSE
+"H2009","Pearson.est","proteasome inhibitor",-0.29843,-0.735,0.784,1097,0.979,"ONX.0914, ixazomib, carfilzomib, delanzomib",0.105683937315562,0.00921730819686218,FALSE
+"H2009","Pearson.est","protein synthesis inhibitor",-0.36018,-0.894,0.583,1074,0.796,"emetine, thiostrepton, bruceantin, tedizolid.phosphate, homoharringtonine, cycloheximide, puromycin",0.234331445240986,0.0990869322623309,FALSE
+"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.81453,-1.97,0.00172,1321,0.0586,"tyrphostin.A9, NVP.TAE226, BMS.599626, CP.724714, AV.412",2.76447155309245,1.23210238398191,TRUE
+"H2009","Pearson.est","RAF inhibitor",0.77208,2,0.00236,60,0.0449,"dabrafenib, vemurafenib, SB.590885, AZ.628, TAK.632",2.62708799702989,1.34775365899668,TRUE
+"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.62262,-1.53,0.0694,1431,0.348,"vandetanib",1.15864052954514,0.458420756053419,FALSE
+"H2009","Pearson.est","retinoid receptor agonist",-0.43973,-1.05,0.406,1186,0.751,"tamibarotene, CD.437, adarotene",0.391473966422806,0.124360062995832,FALSE
+"H2009","Pearson.est","ribonucleotide reductase inhibitor",0.70612,1.79,0.0133,355,0.15,"cladribine, pentostatin, triapine, hydroxyurea, clofarabine, cytarabine, fludarabine",1.87614835903291,0.823908740944319,TRUE
+"H2009","Pearson.est","serotonin receptor agonist",0.51619,1.36,0.137,544,0.57,"aripiprazole, NAN.190, zolmitriptan, SR.57227A, ipsapirone",0.863279432843593,0.244125144327509,FALSE
+"H2009","Pearson.est","serotonin receptor antagonist",0.33329,0.881,0.572,161,0.879,"lerisetron, paliperidone, aripiprazole",0.242603971206976,0.0560111249262281,FALSE
+"H2009","Pearson.est","sodium channel blocker",0.4611,1.2,0.266,321,0.577,"cibenzoline, benzethonium, butamben, mepivacaine, oxcarbazepine, quinidine, mexiletine",0.575118363368933,0.238824186844269,FALSE
+"H2009","Pearson.est","src inhibitor",-0.75769,-1.84,0.00525,1408,0.149,"dasatinib, ZM.306416, bosutinib, saracatinib",2.27984069659404,0.826813731587726,TRUE
+"H2009","Pearson.est","sterol demethylase inhibitor",-0.34066,-0.846,0.641,1385,0.823,"lanoconazole",0.193141970481183,0.0846001647877302,FALSE
+"H2009","Pearson.est","TGF beta receptor inhibitor",-0.50408,-1.22,0.233,1166,0.6,"SB.431542, D.4476, repsox",0.632644078973981,0.221848749616356,FALSE
+"H2009","Pearson.est","thymidylate synthase inhibitor",0.27182,0.704,0.806,398,0.947,"ftorafur, doxifluridine, trifluridine",0.0936649581949093,0.0236500209967266,FALSE
+"H2009","Pearson.est","topoisomerase inhibitor",-0.29219,-0.728,0.773,1006,0.961,"rubitecan, licochalcone.a, fleroxacin, mitoxantrone, irinotecan, amonafide, SN.38, genz.644282, camptothecin, exatecan.mesylate",0.111820506081675,0.0172766123314547,FALSE
+"H2009","Pearson.est","tubulin polymerization inhibitor",-0.50291,-1.24,0.226,1118,0.598,"epothilone.d, dolastatin.10, fenbendazole, fosbretabulin, podophyllotoxin, indibulin, epothilone.b, nocodazole, parbendazole, plinabulin, paclitaxel, docetaxel, mebendazole",0.645891560852599,0.223298816011589,FALSE
+"H2009","Pearson.est","tyrosine kinase inhibitor",-0.65417,-1.65,0.0521,1321,0.24,"tyrphostin.A9, NVP.TAE226, aminopurvalanol.a, BMS.599626, dasatinib, tivantinib, CP.724714, vandetanib, AV.412",1.28316227670048,0.619788758288394,FALSE
+"H2009","Pearson.est","VEGFR inhibitor",-0.39278,-0.972,0.45,1379,0.739,"AEE788, ZM.306416, vandetanib, XL.647, BMS.690514",0.346787486224656,0.131355561605174,FALSE
+"H2009","Pearson.est","vitamin D receptor agonist",-0.58912,-1.45,0.0963,1196,0.405,"calcitriol, ercalcitriol, maxacalcitol",1.01637371287547,0.392544976785331,FALSE
+"H2126","Pearson.est","EGFR inhibitor",-0.49026,-1.36,0.142,1291,0.285,"poziotinib, AZD8931, lapatinib, dacomitinib, CP.724714, osimertinib, AST.1306, WZ.4002, PD.153035, WZ8040, PD.168393, BIBU.1361, tucatinib, BMS.599626",0.847711655616944,0.54515513999149,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",0.62316,1.51,0.0556,145,0.357,"GZD824, ponatinib, metatinib, nilotinib, tozasertib, KW.2449",1.25492520841794,0.447331783887807,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",0.42976,1.02,0.434,181,0.71,"xanomeline, tremorine",0.362510270487489,0.148741651280925,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",0.37364,0.903,0.587,293,0.798,"methscopolamine, darifenacin",0.231361898752386,0.0979971086492706,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.66578,-1.93,0.026,1348,0.109,"SCH.58261, MRS.1220, CGS.15943",1.58502665202918,0.962573502059376,TRUE
+"H2126","Pearson.est","adrenergic receptor agonist",0.35324,0.853,0.627,421,0.845,"clenbuterol, A61603, norepinephrine, terbutaline, epinephrine",0.202732459169284,0.0731432910503077,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",0.24683,0.594,0.922,220,0.96,"idazoxan, carvedilol, atenolol......",0.0352690789463706,0.0177287669604316,FALSE
+"H2126","Pearson.est","AKT inhibitor",-0.51211,-1.44,0.118,1189,0.266,"GSK2110183, CCT128930, palomid.529, AZD5363, AT7867",0.928117992693875,0.575118363368933,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.55189,1.32,0.156,597,0.392,"alectinib, crizotinib, NVP.TAE684, DMH1, brigatinib, AP26113, GW.788388, lorlatinib",0.806875401645538,0.406713932979543,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",-0.59497,-1.65,0.0595,1431,0.162,"RU.58841",1.22548303427145,0.790484985457369,FALSE
+"H2126","Pearson.est","antioxidant",-0.49307,-1.37,0.124,711,0.303,"taurine, rutin, benfotiamine, chlorogenic.acid, mesna, trolox",0.906578314837765,0.518557371497695,FALSE
+"H2126","Pearson.est","AP inhibitor",0.3115,0.752,0.762,114,0.966,"idronoxil",0.1180450286604,0.0150228735845067,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.61822,1.47,0.0727,331,0.405,"k.strophanthidin, digoxin, digitoxigenin, thonzonium, digitoxin, NMS.873, oligomycin.a, ouabain",1.13846558914096,0.392544976785331,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.63705,1.55,0.0444,454,0.396,"danusertib, barasertib.HQPA, barasertib, MK.5108, tozasertib, KW.2449, TAK.901, GSK1070916, AMG900, MK.8745, hesperadin, alisertib, PF.03814735, SNS.314, ENMD.2076, CCT137690, AT.9283, aurora.a.inhibitor.i, PHA.680632",1.35261702988538,0.402304814074488,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30824,0.745,0.781,558,0.958,"valnemulin, tedizolid, radezolid, azithromycin",0.1073489661227,0.0186344909214556,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",-0.21268,-0.592,0.946,1389,1,"nadifloxacin",0.0241088635982073,0,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.58705,1.41,0.0903,364,0.384,"TW.37, oridonin, gossypol",1.04431224968649,0.415668775632469,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.63411,1.53,0.0564,142,0.351,"GZD824, ponatinib, metatinib, nilotinib, tozasertib",1.24872089601666,0.454692883534176,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",0.29498,0.707,0.826,4,0.918,"bentazepam",0.0830199526796178,0.0371573187987575,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",-0.65274,-1.74,0.0289,979,0.133,"I.BET.762, OTX015, JQ1...., I.BET151",1.53910215724345,0.876148359032914,TRUE
+"H2126","Pearson.est","calcium channel blocker",-0.2597,-0.721,0.759,1210,0.927,"SR.33805, cinnarazine, fendiline",0.11975822410452,0.0329202658555029,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.57285,1.38,0.127,27,0.375,"UNBS.5162",0.896196279044043,0.425968732272281,FALSE
+"H2126","Pearson.est","CDK inhibitor",0.3081,0.744,0.781,537,0.94,"PHA.848125, indisulam, abemaciclib, palbociclib, alvocidib, R547, P276.00, PHA.793887, JNJ.7706621, aminopurvalanol.a, dinaciclib",0.1073489661227,0.0268721464003014,FALSE
+"H2126","Pearson.est","CHK inhibitor",0.56244,1.34,0.14,369,0.39,"PF.477736, LY2606368, SCH.900776, SB.218078",0.853871964321762,0.408935392973501,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.21233,-0.591,0.935,303,0.982,"indoprofen, suxibuzone, tepoxalin, amfenac, FK.3311, AM.404, ramifenazone, sulfasalazine, meloxicam, piroxicam, curcumin, ketoprofen, pterostilbene, metoxibutropate, FR.122047, phenazone, aspirin, acetylsalicylsalicylic.acid, tryptanthrin, phenylbutazone, naproxen",0.0291883891274822,0.00788851221305034,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",-0.29632,-0.802,0.68,427,0.838,"PF.4981517, cobicistat, morin, metyrapone, clotrimazole, itraconazole, eplerenone",0.167491087293764,0.0767559813697235,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.55048,1.34,0.145,351,0.39,"cisplatin, dianhydrogalactitol, carmustine, estramustine, melphalan, satraplatin",0.838631997765025,0.408935392973501,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.25614,0.621,0.921,251,0.955,"chlorambucil, valrubicin, carmustine, melphalan",0.0357403698031511,0.0199966284162537,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",0.41384,0.995,0.459,51,0.739,"disulfiram",0.338187314462739,0.131355561605174,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",0.26623,0.64,0.905,126,0.955,"cephalomannine",0.0433514207947967,0.0199966284162537,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",0.47255,1.14,0.313,559,0.565,"cisplatin, artemisinin, floxuridine, altretamine, cyclocytidine, capecitabine, enocitabine, anisomycin, mitomycin.c",0.504455662453552,0.247951552180562,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.57258,-1.61,0.065,1307,0.164,"piperacetazine, nemonapride, thioproperazine, acetophenazine, clebopride, oxiperomide, remoxipride",1.18708664335714,0.785156151952302,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",0.19794,0.479,0.982,695,0.984,"PPT, ethinyl.estradiol, estradiol, estradiol.cypionate",0.00788851221305034,0.00700490156865849,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",-0.32008,-0.872,0.556,1148,0.761,"clomifene, raloxifene, tamoxifen",0.254925208417942,0.118615343229427,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.51763,1.23,0.215,324,0.449,"erdafitinib, dovitinib, regorafenib, MK.2461, lenvatinib",0.667561540084395,0.347753658996677,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.52035,1.24,0.199,352,0.463,"dovitinib, ponatinib, tyrphostin.AG.1296, gilteritinib, tozasertib, KW.2449, lestaurtinib, midostaurin, sorafenib, ENMD.2076",0.701146923590293,0.334419008982047,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",0.36276,0.875,0.62,507,0.827,"fluticasone.propionate, flumethasone.pivalate, betamethasone, halobetasol.propionate, difluprednate, desonide, fludroxycortide, prednisolone.hemisuccinate, ciclesonide, halcinonide, clobetasol.propionate, triamcinolone, dexamethasone.acetate, prednisolone.acetate, rimexolone",0.207608310501746,0.0824944904474534,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.37609,-1.06,0.357,1195,0.56,"kynurenic.acid, LY456236, JNJ.16259685, IEM1754, latrepirdine",0.447331783887807,0.2518119729938,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.38176,-1.03,0.39,1313,0.568,"GSK.3.inhibitor.IX, indirubin, LY2090314",0.408935392973501,0.245651664288981,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.53989,1.28,0.184,176,0.425,"PHA.848125, danusertib, lestaurtinib",0.735182176990464,0.371611069949688,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.58566,1.42,0.0936,528,0.39,"narlaprevir, mericitabine, daclatasvir, embelin, Ro.9187",1.02872415126189,0.408935392973501,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.18304,-0.496,0.988,1347,0.985,"JNJ.26481585, romidepsin, mocetinostat, RG2833",0.00524305541237188,0.00656376950238827,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",-0.38881,-1.1,0.324,556,0.535,"pheniramine, zolantidine, tiotidine, lafutidine, ebastine, BF2.649, famotidine, cyproheptadine, terfenadine, ICI.162846, astemizole, epinastine, cimetidine, levocetirizine, nizatidine, tecastemizole, ranitidine, chloropyramine",0.489454989793388,0.271646217978772,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",0.88529,2.12,0,72,0.00397,"atorvastatin, pitavastatin, fluvastatin, mevastatin",Inf,2.40120949323688,TRUE
+"H2126","Pearson.est","HSP inhibitor",0.5824,1.42,0.1,206,0.39,"NMS.E973, SNX.5422, PU.H71, SNX.2112, BIIB021, ganetespib, NVP.AUY922",1,0.408935392973501,FALSE
+"H2126","Pearson.est","JAK inhibitor",0.3861,0.923,0.568,425,0.799,"ruxolitinib, baricitinib, tozasertib, AZ960, lestaurtinib, WHI.P154, TG.101209, AT.9283, AZD1480",0.245651664288981,0.0974532206860086,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.40606,0.978,0.497,338,0.733,"pazopanib, OSI.930, regorafenib, midostaurin, dasatinib, motesanib, lenvatinib, sorafenib",0.303643611266668,0.134896025358872,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.64693,-1.79,0.0272,1133,0.162,"idasanutlin, AMG.232, CGM097, RITA",1.5654310959658,0.790484985457369,TRUE
+"H2126","Pearson.est","MEK inhibitor",-0.64276,-1.78,0.0226,1154,0.137,"Ro.4987655, PD.184352, refametinib, cobimetinib, AZD8330, TAK.733, nobiletin, PD.198306, trametinib, AS.703026, selumetinib",1.6458915608526,0.863279432843593,TRUE
+"H2126","Pearson.est","MET inhibitor",0.46719,1.13,0.333,274,0.568,"LY2801653, PHA.665752",0.47755576649368,0.245651664288981,FALSE
+"H2126","Pearson.est","microtubule inhibitor",0.63841,1.53,0.0489,335,0.351,"vinblastine, triclabendazole, D.64131, cabazitaxel, vinflunine, podophyllotoxin",1.31069114087638,0.454692883534176,FALSE
+"H2126","Pearson.est","mTOR inhibitor",0.55385,1.33,0.16,413,0.39,"deforolimus, OSI.027, temsirolimus, AZD8055, PF.04691502, SB.2343, LY3023414, NVP.BEZ235, PKI.179, torin.1, everolimus, GSK2126458, AZD2014, MLN0128, PP242, sirolimus, WAY.600, torin.2",0.795880017344075,0.408935392973501,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",0.20427,0.495,0.977,586,0.996,"bindarit, EVP4593, betulinic.acid, BAY.11.7082, BAY.11.7085",0.0101054362812269,0.00174066157630127,FALSE
+"H2126","Pearson.est","opioid receptor agonist",0.37936,0.913,0.579,347,0.797,"spiradoline, trimebutine",0.237321436272564,0.0985416786038876,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",0.31103,0.738,0.787,94,0.896,"talmapimod",0.104025267640935,0.0476919903378748,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.79064,1.9,0.00271,52,0.0709,"talazoparib, olaparib, niraparib, AZD2461",2.56703070912559,1.14935376481693,TRUE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.42714,1.04,0.422,338,0.69,"dovitinib, CP.673451, ponatinib, pazopanib, regorafenib, axitinib, dasatinib, motesanib, lenvatinib, sorafenib",0.374687549038326,0.161150909262745,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.38758,0.933,0.561,699,0.798,"bis.maltolato.oxovanadium.IV., sodium.stibogluconate, BVT.948, CID.5458317, mycophenolic.acid, GSK2830371, alexidine",0.251037138743839,0.0979971086492706,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",0.50702,1.22,0.242,508,0.452,"zardaverine, GSK256066, enoximone, anagrelide, papaverine, YM.976",0.616184634019569,0.344861565188618,FALSE
+"H2126","Pearson.est","PI3K inhibitor",0.52189,1.27,0.181,260,0.426,"buparlisib, BGT226, GDC.0941, PF.04691502, AZD6482, SB.2343, LY3023414, NVP.BEZ235, PKI.179, ZSTK.474, GSK2126458, PI3K.IN.2",0.742321425130815,0.370590400897281,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.72529,1.77,0.0123,296,0.136,"volasertib, rigosertib, GSK461364, BI.2536, HMN.214, NMS.1286937",1.9100948885606,0.866461091629782,TRUE
+"H2126","Pearson.est","potassium channel blocker",0.46312,1.11,0.336,687,0.589,"ibutilide, dofetilide, mepivacaine, ML133",0.473660722610156,0.229884705212898,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",-0.71731,-1.94,0.00877,1393,0.158,"S26948, fenofibrate, GW.501516",2.05700040663396,0.801342913045577,TRUE
+"H2126","Pearson.est","progesterone receptor agonist",0.59145,1.42,0.0846,317,0.39,"nomegestrol.acetate, tanaproget, norethindrone, danazol",1.07262963696098,0.408935392973501,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.31107,0.741,0.781,355,0.926,"MG.132, delanzomib",0.1073489661227,0.0333890133180656,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.58536,1.39,0.114,391,0.377,"clofoctol, cycloheximide, thiostrepton, mercaptopurine, homoharringtonine, puromycin, emetine, harringtonine, tedizolid.phosphate, anguidine",0.943095148663527,0.423658649794207,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.36486,-1.01,0.414,1359,0.561,"CP.724714, BMS.599626",0.382999658879101,0.251037138743839,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.50868,1.23,0.224,585,0.449,"RAF265, regorafenib, sorafenib, LGX818, SB.590885, PLX.4720, CEP.32496",0.649751981665837,0.347753658996677,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.533,1.3,0.16,389,0.408,"regorafenib, sorafenib, cabozantinib",0.795880017344075,0.38933983691012,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.64758,1.58,0.0252,340,0.385,"adapalene, fenretinide, adarotene, LE.135",1.59859945921846,0.414539270491499,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.68695,1.69,0.0244,198,0.208,"fludarabine.phosphate, clofarabine, triapine, gemcitabine, cladribine",1.61261017366127,0.681936665037238,TRUE
+"H2126","Pearson.est","serotonin receptor agonist",0.47908,1.15,0.289,1,0.563,"aripiprazole",0.539102157243452,0.249491605148654,FALSE
+"H2126","Pearson.est","serotonin receptor antagonist",0.56619,1.36,0.129,490,0.391,"aripiprazole, pirenperone, SB.200646, sertindole, RS.16566, lerisetron",0.889410289700751,0.407823242604133,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.30856,0.738,0.815,341,0.896,"butamben, cibenzoline, quinidine, brivaracetam",0.0888423912600234,0.0476919903378748,FALSE
+"H2126","Pearson.est","src inhibitor",0.35082,0.835,0.674,726,0.857,"PP.1, dasatinib, KX2.391, PP.2, masitinib, TG.100572, saracatinib",0.17134010346468,0.0670191780768018,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.45453,1.1,0.351,487,0.592,"chlormidazole, lanoconazole, posaconazole, ketoconazole",0.454692883534176,0.22767829327708,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",-0.4681,-1.3,0.199,675,0.313,"adaprev, D.4476, SB.431542, LY2109761, SB.525334, repsox",0.701146923590293,0.504455662453552,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.56721,1.39,0.104,476,0.377,"doxifluridine, raltitrexed, capecitabine, trifluridine",0.98296666070122,0.423658649794207,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.73992,1.78,0.00543,256,0.166,"topotecan, doxorubicin, etoposide.phosphate, mitoxantrone, teniposide, TAS.103, nemorubicin, etoposide, voreloxin, daunorubicin, dexrazoxane, SN.38, valrubicin, idarubicin, amsacrine, rubitecan, irinotecan, exatecan.mesylate, camptothecin, genz.644282",2.26520017041115,0.779891911959945,TRUE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.59468,1.46,0.0801,442,0.393,"BNC105, vinblastine, verubulin, taltobulin, fosbretabulin, paclitaxel, mebendazole, vindesine, ABT.751, parbendazole, vinorelbine, vincristine, KX2.391, podophyllotoxin, CYT.997, flubendazole, dolastatin.10, plinabulin, epothilone.b, docetaxel, epothilone.d",1.09636748391576,0.405607449624573,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",0.28711,0.681,0.849,578,0.931,"tivantinib, regorafenib, NVP.TAE226, dasatinib, UNC2250, sorafenib, cabozantinib, PP.121, tyrphostin.AG.99, mubritinib, tyrphostin.A9, aminopurvalanol.a, bafetinib, AMG.208",0.0710923097560473,0.0310503190186574,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",0.40622,0.988,0.488,389,0.733,"RAF265, dovitinib, pazopanib, OSI.930, regorafenib, axitinib, foretinib, SAR131675, MK.2461, motesanib, tivozanib, lenvatinib, sorafenib, ENMD.2076, cabozantinib",0.311580177997289,0.134896025358872,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.91214,-2.58,0,1409,0,"ercalcitriol, maxacalcitol, alfacalcidol, doxercalciferol, paricalcitol, tacalcitol",Inf,Inf,TRUE
+"H3255","Pearson.est","EGFR inhibitor",-0.86237,-2.2,0,1354,0.00812,"icotinib, AST.1306, AEE788, BIBX.1382, WZ8040, TAK.285, BIBU.1361, rociletinib, CUDC.101, vandetanib, WZ.4002, gefitinib, PD.168393, BMS.599626, XL.647, lapatinib, ARRY.334543, neratinib, CP.724714, dacomitinib, tucatinib, erlotinib, BMS.690514, pelitinib, AZD8931, canertinib, poziotinib, osimertinib, afatinib",Inf,2.09044397075882,TRUE
+"H3255","Pearson.est","Abl kinase inhibitor",-0.34308,-0.849,0.623,1389,0.918,"bosutinib, ZM.306416",0.20551195334083,0.0371573187987575,FALSE
+"H3255","Pearson.est","acetylcholine receptor agonist",0.29084,0.725,0.793,236,0.903,"tremorine, nicotine",0.100726812682396,0.0443122496864942,FALSE
+"H3255","Pearson.est","acetylcholine receptor antagonist",0.68859,1.76,0.015,181,0.206,"dicycloverine, iododexetimide, methscopolamine",1.82390874094432,0.686132779630847,TRUE
+"H3255","Pearson.est","adenosine receptor antagonist",-0.67191,-1.67,0.0501,1341,0.243,"SCH.58261, MRS.1220, CGS.15943",1.30016227413275,0.614393726401688,FALSE
+"H3255","Pearson.est","adrenergic receptor agonist",0.18702,0.468,0.977,1180,0.988,"terbutaline, norepinephrine, xylazine, clenbuterol, A61603, isoetharine, ritodrine, lidamidine, midodrine, epinephrine, oxymetazoline, isoxsuprine, buphenine, methyldopa, metaraminol",0.0101054362812269,0.00524305541237188,FALSE
+"H3255","Pearson.est","adrenergic receptor antagonist",0.24896,0.625,0.912,351,0.938,"atenolol......, levobunolol, metoprolol, idazoxan, atenolol...., carvedilol",0.0400051616715838,0.0277971616209356,FALSE
+"H3255","Pearson.est","AKT inhibitor",-0.64833,-1.61,0.0426,1132,0.251,"palomid.529, AZD5363, triciribine, CCT128930, GSK2110183, A.674563, GDC.0068, uprosertib",1.37059040089728,0.600326278518962,FALSE
+"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24367,-0.603,0.919,1055,0.992,"NVP.TAE684, CEP.37440, AZD3463, brigatinib",0.0366844886138887,0.00348832784582135,FALSE
+"H3255","Pearson.est","androgen receptor antagonist",0.59939,1.46,0.0933,307,0.571,"bicalutamide, nilutamide, cyproterone.acetate",1.0301183562535,0.243363891754152,FALSE
+"H3255","Pearson.est","antioxidant",0.2778,0.692,0.835,487,0.905,"chlorogenic.acid, taurine, mesna, trolox",0.0783135245163979,0.0433514207947967,FALSE
+"H3255","Pearson.est","AP inhibitor",0.38888,1,0.438,273,0.735,"LCL.161, idronoxil, GDC.0152",0.3585258894959,0.133712660915805,FALSE
+"H3255","Pearson.est","ATPase inhibitor",0.49063,1.25,0.226,189,0.712,"ouabain, digitoxin, digitoxigenin, digoxin",0.645891560852599,0.147520006363144,FALSE
+"H3255","Pearson.est","Aurora kinase inhibitor",-0.18526,-0.464,0.988,264,0.989,"tozasertib, barasertib.HQPA, MK.5108, hesperadin, AMG900, barasertib, SNS.314, KW.2449, AT.9283, PF.03814735, ENMD.2076, alisertib, MK.8745, CCT137690, CYC116, CCT129202, danusertib, GSK1070916, TAK.901, ZM.447439, aurora.a.inhibitor.i, MLN.8054, PHA.680632",0.00524305541237188,0.0048037084028206,FALSE
+"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34296,-0.853,0.622,1153,0.949,"azalomycin.b, azithromycin, tedizolid",0.206209615309181,0.0227337875727074,FALSE
+"H3255","Pearson.est","bacterial DNA gyrase inhibitor",0.3999,1.01,0.444,426,0.771,"sparfloxacin, novobiocin, norfloxacin",0.35261702988538,0.112945621949043,FALSE
+"H3255","Pearson.est","BCL inhibitor",0.42699,1.08,0.351,241,0.787,"TW.37, ABT.737, obatoclax, gossypol",0.454692883534176,0.104025267640935,FALSE
+"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.28738,0.726,0.793,417,0.925,"nilotinib, tozasertib, bafetinib, ponatinib, GZD824",0.100726812682396,0.0338582672609674,FALSE
+"H3255","Pearson.est","benzodiazepine receptor agonist",-0.21394,-0.536,0.954,307,1,"indiplon, lorazepam, eprinomectin, CGS.20625, CL.218872, bentazepam, nefiracetam, zaleplon, temazepam, ZK.93423, gamma.aminobutyric.acid, ivermectin, piperazine",0.0204516252959049,0,FALSE
+"H3255","Pearson.est","bromodomain inhibitor",-0.68296,-1.72,0.0418,1250,0.222,"JQ1...., OTX015, I.BET151",1.37882371822496,0.653647025549361,TRUE
+"H3255","Pearson.est","calcium channel blocker",0.28955,0.728,0.788,274,0.947,"pranidipine, carboxyamidotriazole, mibefradil",0.103473782510445,0.0236500209967266,FALSE
+"H3255","Pearson.est","CC chemokine receptor antagonist",-0.45357,-1.14,0.289,1380,0.656,"ZK811752",0.539102157243452,0.18309616062434,FALSE
+"H3255","Pearson.est","CDK inhibitor",-0.21009,-0.532,0.969,1327,0.988,"aminopurvalanol.a, indisulam, arcyriaflavin.a",0.0136762229492347,0.00524305541237188,FALSE
+"H3255","Pearson.est","CHK inhibitor",0.28871,0.73,0.786,464,0.97,"SCH.900776, LY2606368, SB.218078, AZD7762",0.104577453960592,0.0132282657337552,FALSE
+"H3255","Pearson.est","cyclooxygenase inhibitor",-0.36669,-0.906,0.547,1113,0.886,"aspirin, FR.122047, tryptanthrin, pterostilbene, phenazone, ketoprofen, FK.3311, AM.404, ramifenazone",0.262012673666569,0.0525662781129492,FALSE
+"H3255","Pearson.est","cytochrome P450 inhibitor",0.79098,2.01,0,272,0.0411,"itraconazole, eplerenone, metyrapone, clotrimazole, cobicistat, morin",Inf,1.38615817812393,TRUE
+"H3255","Pearson.est","DNA alkylating agent",0.41804,1.05,0.375,277,0.818,"carboplatin, carmustine, temozolomide, cisplatin, TH.302, dianhydrogalactitol, streptozotocin",0.425968732272281,0.087246696328677,FALSE
+"H3255","Pearson.est","DNA inhibitor",0.38807,0.996,0.45,203,0.716,"carboplatin, carmustine, pibenzimol, chlorambucil",0.346787486224656,0.145086977692144,FALSE
+"H3255","Pearson.est","DNA methyltransferase inhibitor",-0.47916,-1.18,0.281,1405,0.666,"SGI.1027, fdcyd",0.55129368009492,0.176525770829699,FALSE
+"H3255","Pearson.est","DNA polymerase inhibitor",-0.45588,-1.16,0.264,1135,0.659,"adefovir.dipivoxil, famciclovir, cephalomannine, cidofovir",0.578396073130169,0.18111458540599,FALSE
+"H3255","Pearson.est","DNA synthesis inhibitor",0.47593,1.19,0.256,453,0.752,"cyclocytidine, altretamine, cisplatin, artesunate, estramustine.phosphate, nelarabine, CB.10.277, azodicarbonamide",0.59176003468815,0.123782159408358,FALSE
+"H3255","Pearson.est","dopamine receptor antagonist",0.42752,1.08,0.348,226,0.787,"raclopride, isofloxythepin, amisulpride, paliperidone, domperidone",0.458420756053419,0.104025267640935,FALSE
+"H3255","Pearson.est","estrogen receptor agonist",0.30939,0.794,0.708,643,0.917,"estradiol, PPT, estrone, estradiol.cypionate",0.149966742310231,0.0376306643299789,FALSE
+"H3255","Pearson.est","estrogen receptor antagonist",-0.26584,-0.65,0.861,1288,0.971,"raloxifene",0.0649968485463452,0.0127807700919951,FALSE
+"H3255","Pearson.est","FGFR inhibitor",0.29662,0.736,0.788,609,0.987,"erdafitinib, dovitinib, AZD4547, lenvatinib, nintedanib, MK.2461",0.103473782510445,0.00568284733036327,FALSE
+"H3255","Pearson.est","FLT3 inhibitor",0.40101,1,0.441,347,0.735,"gilteritinib, sunitinib, dovitinib, tozasertib, tyrphostin.AG.1296, ponatinib, TG.101348",0.355561410532161,0.133712660915805,FALSE
+"H3255","Pearson.est","glucocorticoid receptor agonist",0.55433,1.38,0.118,473,0.702,"fluticasone.propionate, dexamethasone.acetate, prednisolone.hemisuccinate, halcinonide, flumethasone.pivalate, hydrocortisone, piretanide, triamcinolone, desonide, flumethasone, fluocinolone.acetonide, halobetasol.propionate, clobetasol.propionate, difluprednate, prednisolone.acetate, prednisolone, deflazacort",0.928117992693875,0.153662887870195,FALSE
+"H3255","Pearson.est","glutamate receptor antagonist",-0.26837,-0.674,0.837,1094,0.971,"ACDPP, diazooxonorleucine, IEM1754, LY456236, latrepirdine",0.07727454200674,0.0127807700919951,FALSE
+"H3255","Pearson.est","glycogen synthase kinase inhibitor",0.38135,0.95,0.501,371,0.748,"CHIR.98014, CHIR.99021, tideglusib, TWS.119",0.300162274132754,0.126098402135539,FALSE
+"H3255","Pearson.est","growth factor receptor inhibitor",-0.38118,-0.942,0.529,1221,0.852,"AZD3463, GW.441756",0.276544327964814,0.0695604052332999,FALSE
+"H3255","Pearson.est","HCV inhibitor",0.45154,1.14,0.317,498,0.774,"Ro.9187, daclatasvir, mericitabine, embelin",0.498940737782249,0.111259039317107,FALSE
+"H3255","Pearson.est","HDAC inhibitor",-0.64377,-1.61,0.0529,1202,0.251,"trichostatin.a, R306465, scriptaid, RG2833, belinostat, vorinostat, M.344, panobinostat, givinostat, PCI.24781, SB.939, JNJ.26481585",1.27654432796481,0.600326278518962,FALSE
+"H3255","Pearson.est","histamine receptor antagonist",-0.29447,-0.719,0.773,1147,1,"cyproheptadine, terfenadine, ebastine, tecastemizole, zolantidine, levocetirizine, ranitidine",0.111820506081675,0,FALSE
+"H3255","Pearson.est","HMGCR inhibitor",0.87185,2.18,0,56,0.00986,"mevastatin, atorvastatin, pitavastatin, fluvastatin",Inf,2.00612308505879,TRUE
+"H3255","Pearson.est","HSP inhibitor",-0.43214,-1.07,0.354,1092,0.754,"VER.49009, BIIB021, XL888, guanidine, KW.2478, alvespimycin, tanespimycin",0.450996737974212,0.122628654130226,FALSE
+"H3255","Pearson.est","JAK inhibitor",-0.32917,-0.816,0.675,941,0.943,"lestaurtinib, AZD1480, WHI.P154, pacritinib, atiprimod, ruxolitinib, TG.02, CEP.33779, LY2784544",0.170696227168975,0.0254883072626717,FALSE
+"H3255","Pearson.est","KIT inhibitor",0.21685,0.546,0.945,233,0.979,"telatinib, cediranib, sunitinib",0.0245681914907371,0.00921730819686218,FALSE
+"H3255","Pearson.est","MDM inhibitor",0.52168,1.3,0.176,118,0.651,"idasanutlin, AMG.232, nutlin.3",0.75448733218585,0.186419011431808,FALSE
+"H3255","Pearson.est","MEK inhibitor",0.38106,0.957,0.48,480,0.76,"cobimetinib, PD.318088, MEK162, PD.0325901, refametinib, selumetinib, BIX.02188",0.318758762624413,0.119186407719209,FALSE
+"H3255","Pearson.est","MET inhibitor",-0.30289,-0.753,0.746,1182,1,"NVP.BVU972, INC.280",0.127261172527331,0,FALSE
+"H3255","Pearson.est","microtubule inhibitor",0.52519,1.33,0.176,311,0.694,"secnidazole, vinblastine, estramustine.phosphate, triclabendazole",0.75448733218585,0.158640529545145,FALSE
+"H3255","Pearson.est","mTOR inhibitor",-0.54284,-1.33,0.16,1132,0.447,"palomid.529, PI.103, deforolimus, GDC.0980, PP242, WYE.125132, PKI.179, voxtalisib, GSK2126458, AZD8055, temsirolimus, torin.2, everolimus, PF.05212384, sirolimus",0.795880017344075,0.349692476868064,FALSE
+"H3255","Pearson.est","NFkB pathway inhibitor",0.31596,0.804,0.671,184,0.928,"betulinic.acid, BAY.11.7082",0.173277479831008,0.0324520237811379,FALSE
+"H3255","Pearson.est","opioid receptor agonist",0.47813,1.19,0.274,230,0.752,"cebranopadol, BW.180C, trimebutine",0.562249437179612,0.123782159408358,FALSE
+"H3255","Pearson.est","p38 MAPK inhibitor",-0.81599,-2.03,0,1178,0.041,"CMPD.1, VX.702, talmapimod, SB.242235, TAK.715, SB.239063",Inf,1.38721614328026,TRUE
+"H3255","Pearson.est","PARP inhibitor",0.28433,0.707,0.804,508,0.907,"AG.14361, olaparib, endo.IWR.1, AZD2461",0.0947439512515487,0.0423927129399047,FALSE
+"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.41323,1.02,0.412,383,0.78,"CP.673451, SU014813, telatinib, sunitinib, dovitinib, linifanib, ponatinib, pazopanib, axitinib",0.385102783966865,0.10790539730952,FALSE
+"H3255","Pearson.est","phosphatase inhibitor",0.44294,1.11,0.32,42,0.802,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.494850021680094,0.0958256317158365,FALSE
+"H3255","Pearson.est","phosphodiesterase inhibitor",-0.29334,-0.723,0.767,1091,1,"cilostamide, EMD.53998, avanafil, papaverine",0.115204636051019,0,FALSE
+"H3255","Pearson.est","PI3K inhibitor",-0.37309,-0.95,0.482,1136,0.921,"PI.103, PI.828, GDC.0980, TG.100713, PKI.179, voxtalisib, GSK2126458, CUDC.907, PF.05212384, taselisib, CH5132799, alpelisib",0.31695296176115,0.0357403698031511,FALSE
+"H3255","Pearson.est","PLK inhibitor",-0.61349,-1.56,0.074,1284,0.233,"BI.2536, HMN.214, NMS.1286937",1.13076828026902,0.632644078973981,FALSE
+"H3255","Pearson.est","potassium channel blocker",0.65813,1.67,0.0323,285,0.252,"mepivacaine, dofetilide, ibutilide, ML133",1.4907974776689,0.598599459218456,FALSE
+"H3255","Pearson.est","PPAR receptor agonist",0.55181,1.37,0.129,29,0.656,"clofibrate, fenofibrate",0.889410289700751,0.18309616062434,FALSE
+"H3255","Pearson.est","progesterone receptor agonist",0.51023,1.31,0.181,520,0.682,"norethindrone, norethindrone.acetate, nomegestrol.acetate, norgestrel, danazol",0.742321425130815,0.166215625343521,FALSE
+"H3255","Pearson.est","proteasome inhibitor",0.42006,1.02,0.443,544,0.78,"MG.132, oprozomib, ixazomib, ixazomib.citrate, bortezomib",0.35359627377693,0.10790539730952,FALSE
+"H3255","Pearson.est","protein synthesis inhibitor",-0.38205,-0.95,0.492,1166,0.921,"azomycin..2.nitroimidazole., homoharringtonine, cycloheximide, puromycin, bruceantin, tedizolid.phosphate, anguidine, chloramphenicol.palmitate",0.30803489723264,0.0357403698031511,FALSE
+"H3255","Pearson.est","protein tyrosine kinase inhibitor",-0.76721,-1.9,0.00191,1391,0.0816,"tyrphostin.A9, AV.412, BMS.599626, CP.724714",2.71896663275227,1.08830984124614,TRUE
+"H3255","Pearson.est","RAF inhibitor",0.75916,1.92,0.0124,137,0.0749,"vemurafenib, dabrafenib, AZ.628, SB.590885, TAK.632, LGX818",1.90657831483776,1.12551818230053,TRUE
+"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.58773,-1.47,0.0895,1422,0.286,"vandetanib",1.04817696468409,0.543633966870957,FALSE
+"H3255","Pearson.est","retinoid receptor agonist",-0.64321,-1.6,0.0581,1258,0.212,"bexarotene, CD.437, tamibarotene, adarotene",1.23582386760967,0.673664139071249,FALSE
+"H3255","Pearson.est","ribonucleotide reductase inhibitor",0.60642,1.5,0.0813,268,0.546,"cladribine, clofarabine, hydroxyurea, gemcitabine, fludarabine.phosphate",1.08990945440593,0.262807357295263,FALSE
+"H3255","Pearson.est","serotonin receptor agonist",0.66765,1.68,0.0338,231,0.285,"aripiprazole, SR.57227A",1.47108329972235,0.54515513999149,FALSE
+"H3255","Pearson.est","serotonin receptor antagonist",0.4461,1.14,0.303,207,0.774,"aripiprazole, lerisetron, pirenperone, paliperidone, RS.16566",0.518557371497695,0.111259039317107,FALSE
+"H3255","Pearson.est","sodium channel blocker",0.41024,1.03,0.411,106,0.826,"cibenzoline, mepivacaine, butamben, oxcarbazepine",0.386158178123931,0.0830199526796178,FALSE
+"H3255","Pearson.est","src inhibitor",-0.6385,-1.6,0.0573,1261,0.212,"TG.100572, bosutinib, ZM.306416, saracatinib",1.24184537803261,0.673664139071249,FALSE
+"H3255","Pearson.est","sterol demethylase inhibitor",0.34476,0.872,0.606,228,0.862,"posaconazole, sulconazole",0.217527375833714,0.0644927341752872,FALSE
+"H3255","Pearson.est","TGF beta receptor inhibitor",-0.27847,-0.699,0.803,1016,0.967,"repsox, SB.431542, D.4476",0.095284454721319,0.0145735259169983,FALSE
+"H3255","Pearson.est","thymidylate synthase inhibitor",0.32995,0.84,0.654,370,0.892,"doxifluridine, ftorafur",0.184422251675733,0.0496351456238769,FALSE
+"H3255","Pearson.est","topoisomerase inhibitor",0.2633,0.659,0.865,414,0.924,"etoposide.phosphate, doxorubicin, nemorubicin, topotecan, teniposide, TAS.103, valrubicin, voreloxin, beta.lapachone",0.0629838925351858,0.0343280287798933,FALSE
+"H3255","Pearson.est","tubulin polymerization inhibitor",-0.28647,-0.715,0.797,1199,0.976,"nocodazole, parbendazole, fenbendazole, plinabulin, indibulin, mebendazole",0.0985416786038876,0.0105501823333082,FALSE
+"H3255","Pearson.est","tyrosine kinase inhibitor",-0.60066,-1.54,0.0727,1327,0.232,"aminopurvalanol.a, tivantinib, tyrphostin.A9, vandetanib, AV.412, BMS.599626, CP.724714",1.13846558914096,0.6345120151091,FALSE
+"H3255","Pearson.est","VEGFR inhibitor",-0.38772,-0.942,0.538,1386,0.852,"AEE788, ZM.306416, vandetanib, XL.647, BMS.690514",0.269217724333611,0.0695604052332999,FALSE
+"H3255","Pearson.est","vitamin D receptor agonist",-0.77633,-1.96,0.00204,1143,0.0574,"paricalcitol, tacalcitol, calcitriol, ercalcitriol, maxacalcitol",2.6903698325741,1.24108810760203,TRUE
+"H358","Pearson.est","EGFR inhibitor",-0.86277,-2.13,0,1343,0.014,"CUDC.101, PD.153035, BIBX.1382, WZ.4002, rociletinib, brigatinib, CP.724714, BMS.599626, AEE788, icotinib, WZ8040, GW.583340, TAK.285, ARRY.334543, vandetanib, gefitinib, AST.1306, PD.168393, erlotinib, tucatinib, XL.647, neratinib, BMS.690514, lapatinib, AZD8931, dacomitinib, canertinib, pelitinib, osimertinib, poziotinib, afatinib",Inf,1.85387196432176,TRUE
+"H358","Pearson.est","Abl kinase inhibitor",-0.44464,-1.1,0.352,1416,0.647,"dasatinib, bosutinib, ZM.306416",0.453457336521869,0.1890957193313,FALSE
+"H358","Pearson.est","acetylcholine receptor agonist",0.59246,1.52,0.0747,240,0.479,"nefiracetam, nicotine, tremorine",1.1266793981846,0.319664486585437,FALSE
+"H358","Pearson.est","acetylcholine receptor antagonist",0.46153,1.17,0.275,399,0.709,"iododexetimide, diphemanil, methscopolamine, dicycloverine",0.560667306169737,0.149353764816933,FALSE
+"H358","Pearson.est","adenosine receptor antagonist",-0.47403,-1.15,0.31,1434,0.627,"CGS.15943",0.508638306165727,0.202732459169284,FALSE
+"H358","Pearson.est","adrenergic receptor agonist",-0.53014,-1.31,0.181,836,0.523,"norepinephrine, terbutaline, epinephrine, A61603, metaraminol, oxymetazoline, isoetharine, methyldopa, midodrine, lidamidine, isoxsuprine",0.742321425130815,0.281498311132726,FALSE
+"H358","Pearson.est","adrenergic receptor antagonist",-0.1899,-0.472,0.975,1044,1,"practolol, dihydroergocristine, vincamine, dronedarone, prazosin, RS.17053",0.0109953843014632,0,FALSE
+"H358","Pearson.est","AKT inhibitor",-0.50123,-1.23,0.249,1326,0.589,"uprosertib, CCT128930, triciribine",0.603800652904264,0.229884705212898,FALSE
+"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.56418,-1.37,0.174,1160,0.495,"CEP.37440, SB.505124, NVP.TAE684, crizotinib, AZD3463, brigatinib, AP26113",0.7594507517174,0.305394801066431,FALSE
+"H358","Pearson.est","androgen receptor antagonist",0.37786,0.931,0.529,371,0.865,"nilutamide, bicalutamide",0.276544327964814,0.0629838925351858,FALSE
+"H358","Pearson.est","antioxidant",0.65133,1.63,0.0349,353,0.476,"trolox, mesna, taurine, benfotiamine",1.45717457304082,0.322393047279507,FALSE
+"H358","Pearson.est","AP inhibitor",0.39994,0.983,0.461,78,0.792,"idronoxil",0.336299074610352,0.101274818410506,FALSE
+"H358","Pearson.est","ATPase inhibitor",0.42489,1.06,0.385,280,0.774,"oligomycin.a, digoxin, blebbistatin...., NMS.873",0.414539270491499,0.111259039317107,FALSE
+"H358","Pearson.est","Aurora kinase inhibitor",-0.1713,-0.423,0.993,1027,0.995,"tozasertib, PHA.680632, danusertib, ZM.447439, TAK.901, GSK1070916, aurora.a.inhibitor.i, MLN.8054",0.00305075150461883,0.00217691925427455,FALSE
+"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.2541,-0.622,0.895,1360,0.967,"azithromycin",0.048176964684088,0.0145735259169983,FALSE
+"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.23109,0.574,0.926,151,1,"nadifloxacin",0.0333890133180656,0,FALSE
+"H358","Pearson.est","BCL inhibitor",0.47855,1.21,0.26,283,0.664,"gossypol, ABT.737, TW.37, venetoclax",0.585026652029182,0.177831920631982,FALSE
+"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.35469,-0.861,0.612,1416,0.838,"dasatinib, bosutinib",0.213248577854439,0.0767559813697235,FALSE
+"H358","Pearson.est","benzodiazepine receptor agonist",0.35095,0.866,0.611,470,0.835,"nefiracetam, lorazepam, bentazepam, indiplon, temazepam, zaleplon",0.213958789757446,0.0783135245163979,FALSE
+"H358","Pearson.est","bromodomain inhibitor",0.26962,0.675,0.85,193,0.98,"bromosporine",0.0705810742857073,0.00877392430750515,FALSE
+"H358","Pearson.est","calcium channel blocker",0.32481,0.821,0.646,197,0.86,"carboxyamidotriazole, pranidipine, mibefradil",0.189767482004916,0.0655015487564323,FALSE
+"H358","Pearson.est","CC chemokine receptor antagonist",0.35561,0.901,0.552,105,0.8,"SB.225002",0.258060922270801,0.0969100130080564,FALSE
+"H358","Pearson.est","CDK inhibitor",-0.26815,-0.659,0.854,1108,1,"alvocidib, BMS.265246, kenpaullone, BMS.387032, aminopurvalanol.a, PHA.793887, CR8..R., AT.7519",0.068542129310995,0,FALSE
+"H358","Pearson.est","CHK inhibitor",-0.58873,-1.44,0.126,1000,0.455,"AZD7762, PF.477736, CHIR.124, SCH.900776, LY2606368, LY2603618",0.899629454882437,0.341988603342888,FALSE
+"H358","Pearson.est","cyclooxygenase inhibitor",-0.41056,-1,0.429,1245,0.768,"FK.3311, AM.404, aspirin, ramifenazone, amfenac, tryptanthrin, phenazone",0.367542707815276,0.114638779968488,FALSE
+"H358","Pearson.est","cytochrome P450 inhibitor",0.49933,1.28,0.215,463,0.774,"morin, PF.4981517, metyrapone, cobicistat, clotrimazole",0.667561540084395,0.111259039317107,FALSE
+"H358","Pearson.est","DNA alkylating agent",0.27336,0.676,0.838,402,1,"carboplatin, streptozotocin, carmustine, melphalan, TH.302, temozolomide, dianhydrogalactitol",0.0767559813697235,0,FALSE
+"H358","Pearson.est","DNA inhibitor",0.4898,1.24,0.238,438,0.642,"carboplatin, pibenzimol, oxaliplatin, chlorambucil, carmustine, melphalan, teroxirone, bendamustine, mechlorethamine, metronidazole",0.623423042943488,0.192464971931147,FALSE
+"H358","Pearson.est","DNA methyltransferase inhibitor",-0.53313,-1.32,0.156,1255,0.544,"fdcyd, SGI.1027, azacitidine, decitabine",0.806875401645538,0.26440110030182,FALSE
+"H358","Pearson.est","DNA polymerase inhibitor",-0.38778,-0.952,0.5,1261,0.764,"cidofovir, cephalomannine",0.301029995663981,0.11690664142431,FALSE
+"H358","Pearson.est","DNA synthesis inhibitor",0.23119,0.578,0.936,573,1,"altretamine, artesunate, nelarabine, cyclocytidine, artemisinin, estramustine.phosphate, azodicarbonamide",0.0287241512618947,0,FALSE
+"H358","Pearson.est","dopamine receptor antagonist",0.36593,0.909,0.566,437,0.842,"raclopride, thioproperazine, amisulpride, sertindole, domperidone, paliperidone, isofloxythepin, nemonapride, UH.232....",0.247183568811729,0.0746879085003505,FALSE
+"H358","Pearson.est","estrogen receptor agonist",-0.2643,-0.655,0.872,1223,0.985,"equol, levonorgestrel",0.0594835150674328,0.00656376950238827,FALSE
+"H358","Pearson.est","estrogen receptor antagonist",0.50946,1.27,0.204,238,0.731,"danazol, fulvestrant, toremifene",0.690369832574101,0.13608262304214,FALSE
+"H358","Pearson.est","FGFR inhibitor",0.49484,1.25,0.229,190,0.667,"erdafitinib, regorafenib, orantinib",0.640164517660112,0.175874166083451,FALSE
+"H358","Pearson.est","FLT3 inhibitor",0.19092,0.477,0.984,122,0.985,"TG.101348, GTP.14564",0.00700490156865849,0.00656376950238827,FALSE
+"H358","Pearson.est","glucocorticoid receptor agonist",0.39694,0.991,0.458,361,0.809,"dexamethasone.acetate, piretanide, triamcinolone, halcinonide, prednisolone.hemisuccinate, flumethasone.pivalate, deflazacort, fluticasone.propionate, rimexolone, desonide",0.339134521996131,0.0920514783877277,FALSE
+"H358","Pearson.est","glutamate receptor antagonist",0.30937,0.757,0.73,372,0.916,"MTPG, ACDPP, IEM1754, felbamate, JNJ.16259685",0.136677139879544,0.0381045263321496,FALSE
+"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.32297,-0.808,0.678,1180,0.844,"kenpaullone, AZD2858, LY2090314",0.168770306132937,0.073657553374345,FALSE
+"H358","Pearson.est","growth factor receptor inhibitor",-0.34075,-0.839,0.625,937,0.849,"GW.441756, danusertib, AZD3463",0.204119982655925,0.0710923097560473,FALSE
+"H358","Pearson.est","HCV inhibitor",0.51406,1.26,0.21,157,0.697,"mericitabine, narlaprevir",0.677780705266081,0.156767221901991,FALSE
+"H358","Pearson.est","HDAC inhibitor",0.20852,0.522,0.978,416,1,"NSC.3852, nexturastat.a, M.344, entinostat, scriptaid, R306465, RGFP966, ACY.1215",0.00966114521239857,0,FALSE
+"H358","Pearson.est","histamine receptor antagonist",-0.44366,-1.1,0.333,1189,0.647,"cimetidine, terfenadine, ranitidine, ebastine, levocetirizine, zolantidine",0.47755576649368,0.1890957193313,FALSE
+"H358","Pearson.est","HMGCR inhibitor",0.80884,2.03,0,68,0.0305,"atorvastatin, mevastatin, fluvastatin, pitavastatin",Inf,1.51570016065321,TRUE
+"H358","Pearson.est","HSP inhibitor",-0.79524,-1.99,0.00377,1299,0.0348,"guanidine, XL888, ganetespib, NVP.AUY922, tanespimycin, alvespimycin, PU.H71, KW.2478, VER.49009, BIIB021",2.42365864979421,1.45842075605342,TRUE
+"H358","Pearson.est","JAK inhibitor",-0.23519,-0.574,0.935,1143,0.985,"LY2784544, pacritinib, CEP.33779, AZD1480, ruxolitinib",0.0291883891274822,0.00656376950238827,FALSE
+"H358","Pearson.est","KIT inhibitor",-0.31418,-0.762,0.73,1165,0.891,"OSI.930, imatinib, midostaurin, tandutinib, dasatinib",0.136677139879544,0.0501222959631252,FALSE
+"H358","Pearson.est","MDM inhibitor",0.83963,2.14,0,63,0.0161,"idasanutlin, AMG.232, nutlin.3, CGM097",Inf,1.79317412396815,TRUE
+"H358","Pearson.est","MEK inhibitor",0.35837,0.906,0.546,502,0.819,"cobimetinib, U.0126, PD.318088, selumetinib, MEK162, arctigenin, MEK1.2.inhibitor, BIX.02188, refametinib, PD.0325901",0.262807357295263,0.0867160982395816,FALSE
+"H358","Pearson.est","MET inhibitor",-0.63762,-1.56,0.06,1377,0.331,"LY2801653, INC.280",1.22184874961636,0.480172006224281,FALSE
+"H358","Pearson.est","microtubule inhibitor",-0.49197,-1.2,0.268,1148,0.573,"colchicine, cytochalasin.b, podophyllotoxin, cabazitaxel",0.571865205971211,0.24184537803261,FALSE
+"H358","Pearson.est","mTOR inhibitor",0.31414,0.795,0.71,427,0.879,"ku.0063794, XL388, LY303511, SB.2343, AZD2014, PF.04691502, WAY.600, WYE.125132, PP242, OSI.027, PI.103, torin.1, MLN0128",0.148741651280925,0.0560111249262281,FALSE
+"H358","Pearson.est","NFkB pathway inhibitor",0.43885,1.1,0.341,275,0.732,"parthenolide...., tyloxapol, BAY.11.7082, betulinic.acid",0.467245621007502,0.135488918941608,FALSE
+"H358","Pearson.est","opioid receptor agonist",0.4146,1.05,0.387,230,0.759,"BW.180C, trimebutine",0.412289034981089,0.11975822410452,FALSE
+"H358","Pearson.est","p38 MAPK inhibitor",-0.60835,-1.53,0.0846,1002,0.341,"TAK.715, CMPD.1, talmapimod, SB.239063, SB.242235",1.07262963696098,0.467245621007502,FALSE
+"H358","Pearson.est","PARP inhibitor",0.33832,0.859,0.64,285,0.821,"AG.14361, endo.IWR.1",0.193820026016113,0.0856568428805592,FALSE
+"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.20056,0.511,0.971,190,0.996,"KI.8751, pazopanib, regorafenib, orantinib",0.0127807700919951,0.00174066157630127,FALSE
+"H358","Pearson.est","phosphatase inhibitor",0.54531,1.37,0.137,159,0.696,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948",0.863279432843593,0.157390760389438,FALSE
+"H358","Pearson.est","phosphodiesterase inhibitor",0.43093,1.1,0.329,31,0.732,"anagrelide, GSK256066",0.482804102050026,0.135488918941608,FALSE
+"H358","Pearson.est","PI3K inhibitor",-0.31741,-0.809,0.674,1308,0.87,"TG.100713, PIK.75, CH5132799, PF.05212384, alpelisib, taselisib",0.17134010346468,0.0604807473813815,FALSE
+"H358","Pearson.est","PLK inhibitor",-0.67078,-1.65,0.0517,1091,0.274,"rigosertib, HMN.214, BI.2536, NMS.1286937",1.28650945690606,0.562249437179612,FALSE
+"H358","Pearson.est","potassium channel blocker",0.36712,0.927,0.538,608,0.84,"mepivacaine, meglitinide, ML133, ibutilide",0.269217724333611,0.0757207139381184,FALSE
+"H358","Pearson.est","PPAR receptor agonist",0.63054,1.62,0.0404,440,0.404,"clofibrate, fenofibrate, GW.501516, pterostilbene, S26948",1.3936186348894,0.393618634889395,FALSE
+"H358","Pearson.est","progesterone receptor agonist",0.63394,1.61,0.0261,164,0.357,"norethindrone, norethindrone.acetate, tanaproget, danazol, norgestrel",1.58335949266172,0.447331783887807,FALSE
+"H358","Pearson.est","proteasome inhibitor",-0.39174,-0.931,0.516,1025,0.772,"ixazomib.citrate, ixazomib, bortezomib, ONX.0914, carfilzomib",0.287350298372789,0.112382699664264,FALSE
+"H358","Pearson.est","protein synthesis inhibitor",0.25116,0.627,0.909,268,1,"mercaptopurine, clofoctol, brefeldin.a, clindamycin.phosphate",0.0414361167780325,0,FALSE
+"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.7263,-1.76,0.0174,1399,0.161,"CP.724714, BMS.599626, AV.412",1.7594507517174,0.79317412396815,TRUE
+"H358","Pearson.est","RAF inhibitor",0.79479,1.99,0.00789,179,0.0354,"dabrafenib, SB.590885, AZ.628, vemurafenib, LGX818, TAK.632, RAF265, regorafenib, GDC.0879",2.10292299679058,1.45099673797421,TRUE
+"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.49567,-1.21,0.241,1426,0.589,"vandetanib",0.617982957425132,0.229884705212898,FALSE
+"H358","Pearson.est","retinoid receptor agonist",-0.37036,-0.92,0.521,1290,0.763,"adarotene, CD.437, tamibarotene",0.283162276700476,0.11747546204512,FALSE
+"H358","Pearson.est","ribonucleotide reductase inhibitor",0.50951,1.28,0.207,451,0.774,"triapine, cladribine, pentostatin, clofarabine, fludarabine, hydroxyurea, fludarabine.phosphate",0.684029654543082,0.111259039317107,FALSE
+"H358","Pearson.est","serotonin receptor agonist",0.55504,1.4,0.146,175,0.694,"aripiprazole, NAN.190",0.835647144215563,0.158640529545145,FALSE
+"H358","Pearson.est","serotonin receptor antagonist",0.41361,1.01,0.426,83,0.804,"aripiprazole, lerisetron",0.370590400897281,0.0947439512515487,FALSE
+"H358","Pearson.est","sodium channel blocker",0.44857,1.14,0.318,119,0.731,"cibenzoline, benzethonium, butamben, quinidine",0.497572880015567,0.13608262304214,FALSE
+"H358","Pearson.est","src inhibitor",-0.79685,-1.94,0.00398,1416,0.0434,"dasatinib, bosutinib, ZM.306416, saracatinib",2.40011692792631,1.36251027048749,TRUE
+"H358","Pearson.est","sterol demethylase inhibitor",-0.39822,-0.961,0.491,1293,0.809,"lanoconazole",0.308918507877032,0.0920514783877277,FALSE
+"H358","Pearson.est","TGF beta receptor inhibitor",-0.67317,-1.63,0.0435,1133,0.261,"SB.431542, D.4476, repsox",1.36151074304536,0.583359492661719,FALSE
+"H358","Pearson.est","thymidylate synthase inhibitor",-0.26428,-0.654,0.862,1195,0.959,"capecitabine, carmofur",0.0644927341752872,0.0181813928293364,FALSE
+"H358","Pearson.est","topoisomerase inhibitor",-0.38764,-0.956,0.496,1198,0.786,"etoposide, rubitecan, fleroxacin, licochalcone.a, SN.38, genz.644282, irinotecan, exatecan.mesylate, camptothecin",0.304518323509803,0.104577453960592,FALSE
+"H358","Pearson.est","tubulin polymerization inhibitor",-0.56515,-1.4,0.145,1168,0.482,"fosbretabulin, mebendazole, vincristine, oxibendazole, indibulin, dolastatin.10, podophyllotoxin, nocodazole, parbendazole, epothilone.b, plinabulin, paclitaxel, docetaxel",0.838631997765025,0.31695296176115,FALSE
+"H358","Pearson.est","tyrosine kinase inhibitor",-0.52248,-1.29,0.204,1399,0.522,"CP.724714, BMS.599626, dasatinib, tivantinib, vandetanib, AV.412",0.690369832574101,0.282329496997738,FALSE
+"H358","Pearson.est","VEGFR inhibitor",-0.43401,-1.07,0.368,1341,0.67,"foretinib, AEE788, ZM.306416, vandetanib, XL.647, BMS.690514",0.434152181326482,0.173925197299174,FALSE
+"H358","Pearson.est","vitamin D receptor agonist",-0.84099,-2.08,0,1302,0.0154,"tacalcitol, ercalcitriol, calcitriol, paricalcitol, maxacalcitol",Inf,1.81247927916354,TRUE
+"A549","Pearson.est","EGFR inhibitor",0.8388,2.26,0,100,0.0178,"tucatinib, BMS.599626, osimertinib, poziotinib, AZD8931, CUDC.101, dacomitinib, AST.1306, afatinib, canertinib, WZ8040, pelitinib, BMS.690514, CP.724714, neratinib, ARRY.334543, lapatinib, AEE788, gefitinib, BIBU.1361, PD.168393, PD.153035, rociletinib, erlotinib, BIBX.1382, XL.647, CNX.2006, GW.583340, WZ.4002",Inf,1.74957999769111,TRUE
+"A549","Pearson.est","Abl kinase inhibitor",-0.58184,-1.43,0.0924,1290,0.466,"metatinib, flumatinib, dasatinib, ponatinib, GZD824, nilotinib",1.03432802877989,0.33161408331,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",-0.38662,-0.952,0.526,871,0.787,"nefiracetam, xanomeline, pilocarpine, nicotine",0.279014255846261,0.104025267640935,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",-0.51821,-1.24,0.231,1192,0.509,"darifenacin, iododexetimide, methscopolamine",0.636388020107856,0.293282217663241,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.67812,1.76,0.0251,86,0.107,"CGS.15943, MRS.1220, SCH.58261",1.60032627851896,0.97061622231479,TRUE
+"A549","Pearson.est","adrenergic receptor agonist",-0.16272,-0.396,0.998,1160,0.998,"buphenine, clenbuterol",0.000869458712628891,0.000869458712628891,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",-0.29013,-0.716,0.826,1112,0.985,"imiloxan, naftidrofuryl, carvedilol, levobunolol, idazoxan",0.0830199526796178,0.00656376950238827,FALSE
+"A549","Pearson.est","AKT inhibitor",0.73638,1.88,0.0138,111,0.0874,"uprosertib, GDC.0068, AZD5363, CCT128930, GSK2110183",1.86012091359876,1.0584885673656,TRUE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.29121,-0.7,0.804,1433,0.984,"lorlatinib",0.0947439512515487,0.00700490156865849,FALSE
+"A549","Pearson.est","androgen receptor antagonist",-0.52332,-1.29,0.192,923,0.46,"bicalutamide, cyproterone.acetate, flutamide, nilutamide",0.71669877129645,0.337242168318426,FALSE
+"A549","Pearson.est","antioxidant",-0.63843,-1.59,0.0386,1041,0.328,"taurine, chlorogenic.acid, trolox, rutin, benfotiamine",1.41341269532825,0.484126156288321,FALSE
+"A549","Pearson.est","AP inhibitor",-0.37272,-0.91,0.572,1415,0.779,"idronoxil",0.242603971206976,0.108462542327436,FALSE
+"A549","Pearson.est","ATPase inhibitor",-0.73068,-1.77,0.0129,1321,0.205,"ouabain, digitoxin, k.strophanthidin, digoxin, digitoxigenin",1.88941028970075,0.688246138944246,TRUE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.27432,-0.663,0.851,847,0.987,"barasertib, CYC116, danusertib, PF.03814735, AT.9283, alisertib, KW.2449, AMG900, tozasertib, hesperadin, MK.8745, MK.5108",0.0700704399154121,0.00568284733036327,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.39151,-0.971,0.492,921,0.799,"dirithromycin, radezolid, tedizolid, valnemulin",0.30803489723264,0.0974532206860086,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.3102,-0.78,0.733,1254,0.912,"lomefloxacin, sparfloxacin",0.134896025358872,0.0400051616715838,FALSE
+"A549","Pearson.est","BCL inhibitor",-0.33043,-0.799,0.707,1362,0.902,"gossypol",0.150580586203101,0.0447934624580583,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.74309,-1.81,0.00759,1290,0.221,"metatinib, flumatinib, dasatinib, ponatinib, GZD824, nilotinib",2.11975822410452,0.655607726314889,TRUE
+"A549","Pearson.est","benzodiazepine receptor agonist",-0.22882,-0.556,0.957,871,1,"nefiracetam, CGS.20625, indiplon, lorazepam, bentazepam",0.0190880622231565,0,FALSE
+"A549","Pearson.est","bromodomain inhibitor",0.78246,2.05,0.00277,186,0.0307,"I.BET151, PFI.1, JQ1...., OTX015",2.55752023093555,1.51286162452281,TRUE
+"A549","Pearson.est","calcium channel blocker",0.21734,0.571,0.947,376,1,"fendiline, mibefradil, SR.33805, efonidipine.monoethanolate",0.0236500209967266,0,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",0.31668,0.83,0.62,373,0.9,"PF.04136309, ZK811752, RS.504393, SB.225002",0.207608310501746,0.0457574905606751,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.23091,-0.555,0.937,1359,1,"palbociclib, abemaciclib, PHA.848125",0.0282604091122217,0,FALSE
+"A549","Pearson.est","CHK inhibitor",-0.23297,-0.567,0.947,1079,1,"LY2606368, SCH.900776",0.0236500209967266,0,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",-0.27802,-0.67,0.854,1193,0.999,"FK.3311, suxibuzone, acetylsalicylsalicylic.acid, AM.404, tepoxalin",0.068542129310995,0.000434511774017692,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",-0.58317,-1.41,0.113,925,0.44,"PF.4981517, clotrimazole, cobicistat, metyrapone",0.94692155651658,0.356547323513813,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.52919,-1.31,0.154,1263,0.492,"temozolomide, carmustine, cisplatin, dianhydrogalactitol, carboplatin",0.812479279163537,0.30803489723264,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.46743,-1.15,0.293,1266,0.568,"carmustine, chlorambucil, teroxirone, carboplatin",0.533132379645891,0.245651664288981,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.59335,1.56,0.0932,77,0.202,"SGI.1027, fdcyd, azacitidine",1.03058408764602,0.694648630553376,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",0.35205,0.935,0.474,461,0.832,"cidofovir, cephalomannine, famciclovir, menadione, idoxuridine, adefovir.dipivoxil",0.324221658325915,0.0798766737092761,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.66192,-1.62,0.0351,1165,0.383,"altretamine, floxuridine, CB.10.277, cyclocytidine, azodicarbonamide, nelarabine, artemisinin, cisplatin",1.45469288353418,0.416801226031377,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",0.33839,0.864,0.586,148,0.88,"lurasidone, oxiperomide, domperidone, acetophenazine",0.232102383981909,0.0555173278498314,FALSE
+"A549","Pearson.est","estrogen receptor agonist",0.23125,0.605,0.909,1115,1,"erteberel, equol, levonorgestrel, estrone, estradiol, ethinyl.estradiol, PPT, estradiol.cypionate",0.0414361167780325,0,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.52714,1.36,0.137,74,0.319,"tamoxifen, clomifene",0.863279432843593,0.496209316942819,FALSE
+"A549","Pearson.est","FGFR inhibitor",-0.57331,-1.42,0.117,1046,0.452,"MK.2461, AZD4547, lenvatinib, nintedanib, regorafenib, erdafitinib",0.931814138253838,0.344861565188618,FALSE
+"A549","Pearson.est","FLT3 inhibitor",-0.39978,-0.95,0.502,879,0.769,"lestaurtinib, dovitinib, tyrphostin.AG.1296, TG.101348, KW.2449, tozasertib, quizartinib, sorafenib, midostaurin, ponatinib, gilteritinib",0.299296282854981,0.114073660198569,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.19133,-0.461,0.989,1002,1,"desonide, dexamethasone.acetate, flumethasone.pivalate, difluprednate, fluocinolone.acetonide, halobetasol.propionate, fluticasone.propionate",0.0048037084028206,0,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.46861,1.22,0.236,325,0.455,"latrepirdine, CGP.37849, CPP, IEM1754, LY456236, kynurenic.acid",0.627087997029893,0.341988603342888,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",0.18157,0.467,0.989,246,0.99,"indirubin, LY2090314",0.0048037084028206,0.00436480540245009,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",0.37361,1.01,0.404,175,0.778,"GSK1904529A, GW.441756, AZD3463",0.393618634889395,0.109020403010311,FALSE
+"A549","Pearson.est","HCV inhibitor",-0.36372,-0.895,0.586,1022,0.785,"embelin, Ro.9187, mericitabine",0.232102383981909,0.105130343254747,FALSE
+"A549","Pearson.est","HDAC inhibitor",0.38293,1,0.411,275,0.749,"givinostat, R306465, PCI.24781, SB.939, pyroxamide, romidepsin, RG2833, JNJ.26481585",0.386158178123931,0.125518182300534,FALSE
+"A549","Pearson.est","histamine receptor antagonist",0.22816,0.612,0.915,212,1,"chloropyramine, terfenadine, cyproheptadine, astemizole",0.0385789059335517,0,FALSE
+"A549","Pearson.est","HMGCR inhibitor",-0.89094,-2.16,0,1437,0.00103,"atorvastatin, pitavastatin, mevastatin, fluvastatin",Inf,2.98716277529483,TRUE
+"A549","Pearson.est","HSP inhibitor",-0.24376,-0.593,0.921,1043,1,"NVP.AUY922, PU.H71, ganetespib, SNX.2112, NMS.E973",0.0357403698031511,0,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.33766,-0.82,0.668,874,0.889,"PRT062070, lestaurtinib, AT.9283, baricitinib, TG.101348, WHI.P154, ruxolitinib, tozasertib, TG.101209, AZ960",0.175223537524454,0.0510982390297863,FALSE
+"A549","Pearson.est","KIT inhibitor",-0.47634,-1.14,0.322,1155,0.567,"lenvatinib, sorafenib, midostaurin, regorafenib, dasatinib, pazopanib, KI.8751",0.492144128304169,0.246416941107093,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.57364,-1.36,0.151,1174,0.446,"CGM097, AMG.232, nutlin.3, idasanutlin",0.821023052706831,0.350665141287858,FALSE
+"A549","Pearson.est","MEK inhibitor",0.80533,2.06,0.0138,142,0.0378,"trametinib, AS.703026, selumetinib, AZD8330, MEK162, PD.318088, TAK.733, PD.0325901, cobimetinib, PD.198306, Ro.4987655, PD.184352",1.86012091359876,1.42250820016277,TRUE
+"A549","Pearson.est","MET inhibitor",-0.43916,-1.09,0.356,1418,0.638,"LY2801653",0.448550002027125,0.195179321278838,FALSE
+"A549","Pearson.est","microtubule inhibitor",-0.52195,-1.26,0.216,1010,0.493,"cabazitaxel, D.64131, vinflunine, vinblastine, secnidazole",0.665546248849069,0.30715308072277,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.54871,-1.32,0.159,1049,0.499,"everolimus, voxtalisib, torin.2, AZD8055, XL388, ku.0063794, SB.2343, AZD2014, PKI.179, temsirolimus, NVP.BEZ235, MLN0128, sirolimus, torin.1, WAY.600, LY3023414, deforolimus",0.798602875679548,0.30189945437661,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",0.25653,0.68,0.846,283,1,"tyloxapol, Ro.106.9920, curcumin, parthenolide....",0.0726296369609765,0,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.50313,-1.23,0.231,1168,0.505,"salvinorin.a, BW.180C, spiradoline",0.636388020107856,0.296708621881339,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",0.51478,1.39,0.122,375,0.313,"skepinone.l, SB.239063, TAK.715, talmapimod",0.913640169325252,0.504455662453552,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.47245,-1.15,0.305,856,0.568,"niraparib, E7449, endo.IWR.1, AZD2461, olaparib, talazoparib, AG.14361",0.515700160653214,0.245651664288981,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52221,-1.29,0.188,1155,0.46,"lenvatinib, nintedanib, sorafenib, crenolanib, regorafenib, dasatinib, ponatinib, pazopanib, KI.8751, CP.673451",0.72584215073632,0.337242168318426,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.47463,-1.18,0.286,1278,0.556,"BVT.948, GSK2830371, bis.maltolato.oxovanadium.IV.",0.543633966870957,0.254925208417942,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",-0.59434,-1.43,0.0951,1231,0.466,"YM.976, anagrelide, zardaverine, GSK256066",1.02181948306259,0.33161408331,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.22358,-0.54,0.962,1042,0.996,"GDC.0941, voxtalisib, BGT226, AZD6482, SB.2343, idelalisib, ZSTK.474, PKI.179, NVP.BEZ235, LY3023414",0.0168249279621871,0.00174066157630127,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.61436,-1.52,0.0656,1304,0.434,"volasertib, rigosertib",1.18309616062434,0.362510270487489,FALSE
+"A549","Pearson.est","potassium channel blocker",-0.59778,-1.45,0.0734,862,0.507,"ML133, mepivacaine, oleoylethanolamide, meglitinide, dofetilide, ibutilide",1.13430394008393,0.294992040666664,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.6468,1.71,0.0373,157,0.121,"ciprofibrate, GW.501516, pterostilbene, S26948",1.42829116819131,0.91721462968355,TRUE
+"A549","Pearson.est","progesterone receptor agonist",-0.53175,-1.29,0.19,1053,0.46,"norethindrone.acetate, norgestrel, tanaproget, nomegestrol.acetate, norethindrone",0.721246399047171,0.337242168318426,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.25378,0.657,0.857,241,1,"carfilzomib, ONX.0914",0.0670191780768018,0,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.37338,-0.917,0.547,974,0.787,"methacycline, emetine, thiostrepton, florfenicol, harringtonine, cycloheximide, mercaptopurine",0.262012673666569,0.104025267640935,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",0.71444,1.86,0.016,46,0.0812,"BMS.599626, CP.724714, AV.412",1.79588001734408,1.09044397075882,TRUE
+"A549","Pearson.est","RAF inhibitor",-0.39851,-0.991,0.464,1178,0.782,"LGX818, sorafenib, RAF265, regorafenib",0.333482019445119,0.106793246940152,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.60093,-1.47,0.07,1200,0.505,"sorafenib, apatinib, regorafenib",1.15490195998574,0.296708621881339,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.53837,1.43,0.127,170,0.297,"adarotene, tamibarotene, CD.437, AM.580",0.896196279044043,0.527243550682788,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.63612,-1.59,0.0574,1271,0.328,"gemcitabine, triapine, fludarabine.phosphate, cladribine, clofarabine",1.24108810760203,0.484126156288321,FALSE
+"A549","Pearson.est","serotonin receptor agonist",-0.71849,-1.72,0.019,1315,0.226,"SR.57227A, aripiprazole",1.72124639904717,0.645891560852599,TRUE
+"A549","Pearson.est","serotonin receptor antagonist",-0.4146,-1,0.44,1103,0.788,"RS.16566, pirenperone, lerisetron, SB.216641, aripiprazole",0.356547323513813,0.103473782510445,FALSE
+"A549","Pearson.est","sodium channel blocker",-0.37723,-0.919,0.556,1255,0.805,"oxcarbazepine, quinidine, butamben, cibenzoline",0.254925208417942,0.0942041196321315,FALSE
+"A549","Pearson.est","src inhibitor",0.22599,0.597,0.944,43,1,"ZM.306416",0.025028005701931,0,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",-0.57159,-1.4,0.106,996,0.428,"posaconazole, chlormidazole, ketoconazole, lanoconazole",0.97469413473523,0.368556230986828,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",0.67721,1.83,0.0163,234,0.0828,"repsox, D.4476, SB.431542",1.78781239559604,1.08196966321512,TRUE
+"A549","Pearson.est","thymidylate synthase inhibitor",-0.49813,-1.19,0.244,737,0.558,"capecitabine, trifluridine, doxifluridine, ftorafur",0.612610173661271,0.253365801062421,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.56253,-1.36,0.117,1045,0.446,"amsacrine, SN.38, mitoxantrone, etoposide, idarubicin, nemorubicin, daunorubicin, dexrazoxane, voreloxin, rubitecan, doxorubicin, epirubicin, teniposide, TAS.103, topotecan, etoposide.phosphate",0.931814138253838,0.350665141287858,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",-0.38607,-0.954,0.529,1189,0.806,"vindesine, epothilone.d, mebendazole, vinblastine, verubulin, BNC105",0.276544327964814,0.0936649581949093,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",0.31846,0.865,0.613,122,0.927,"BMS.599626, CP.724714, AV.412, hypericin",0.212539525481585,0.0329202658555029,FALSE
+"A549","Pearson.est","VEGFR inhibitor",0.19483,0.522,0.978,84,1,"BMS.690514, AEE788, ZM.306416, XL.647",0.00966114521239857,0,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",0.86079,2.25,0,145,0.00891,"maxacalcitol, tacalcitol, paricalcitol, alfacalcidol, calcitriol, ercalcitriol",Inf,2.05012229596313,TRUE
+"HCC15","Pearson.est","EGFR inhibitor",-0.37293,-1.13,0.248,1256,0.693,"BMS.599626, PD.153035, brigatinib, FERb.033, erlotinib, dacomitinib, pelitinib, BIBU.1361, icotinib, canertinib, lapatinib, XL.647, BMS.690514, WZ.4002, PD.168393, vandetanib",0.605548319173784,0.159266765388193,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",-0.22761,-0.71,0.81,1446,0.899,"dasatinib",0.0915149811213502,0.0462403082667712,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",0.51058,1.19,0.248,201,0.586,"xanomeline, oxiracetam, tremorine",0.605548319173784,0.232102383981909,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.33703,-0.993,0.4,486,0.862,"darifenacin, diphemanil, methscopolamine, hyoscyamine, iododexetimide, dicycloverine",0.397940008672038,0.0644927341752872,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",0.56939,1.33,0.125,250,0.557,"MRS.1220, SCH.58261, sulmazole",0.903089986991944,0.254144804826271,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",-0.23866,-0.734,0.834,342,0.908,"A61603, metaraminol, norepinephrine, buphenine, terbutaline, methyldopa, clenbuterol, epinephrine, oxymetazoline, xylazine, lidamidine, ritodrine, midodrine, isoxsuprine, isoetharine",0.0788339493622613,0.0419141514789149,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",-0.23314,-0.668,0.809,1305,0.874,"metoprolol, naftidrofuryl, levobunolol, practolol",0.0920514783877277,0.058488567365597,FALSE
+"HCC15","Pearson.est","AKT inhibitor",0.45118,1.07,0.405,557,0.711,"uprosertib, GDC.0068, MK.2206, AZD5363, ONC201, CCT128930, A.674563, GSK2110183",0.392544976785331,0.148130399270234,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34379,-0.984,0.437,1257,0.815,"AP26113, brigatinib, GW.788388, lorlatinib",0.359518563029578,0.0888423912600234,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.64216,-1.95,0.00641,926,0.106,"flutamide, bicalutamide, enzalutamide, nilutamide, cyproterone.acetate, RU.58841",2.19314197048118,0.97469413473523,TRUE
+"HCC15","Pearson.est","antioxidant",-0.70687,-2.04,0.0061,1340,0.202,"mesna, benfotiamine, trolox",2.21467016498923,0.694648630553376,TRUE
+"HCC15","Pearson.est","AP inhibitor",0.38283,0.898,0.599,633,0.924,"idronoxil, birinapant, tanshinone.i",0.222573177610689,0.0343280287798933,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",0.63423,1.49,0.0581,242,0.456,"NMS.873, thonzonium, oligomycin.a, evodiamine, digoxin",1.23582386760967,0.341035157335565,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",0.6275,1.44,0.0711,403,0.478,"TAK.901, barasertib, PHA.680632, danusertib, barasertib.HQPA, AMG900, SNS.314, GSK1070916, ZM.447439, CCT137690, aurora.a.inhibitor.i, MK.5108, alisertib, tozasertib, AT.9283, ENMD.2076, KW.2449",1.14813039927023,0.320572103387881,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.27431,-0.796,0.717,395,1,"azalomycin.b, valnemulin, azithromycin, radezolid, tedizolid, tilmicosin, josamycin, dirithromycin",0.1444808443322,0,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",-0.25972,-0.784,0.767,374,0.965,"trovafloxacin, novobiocin, sarafloxacin, sparfloxacin, nadifloxacin, lomefloxacin, norfloxacin, finafloxacin",0.115204636051019,0.0154726866562074,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.4201,0.992,0.476,189,0.839,"TW.37, oridonin",0.322393047279507,0.0762380391712997,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.26327,-0.76,0.783,1446,0.912,"dasatinib",0.106238237942057,0.0400051616715838,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.22155,0.524,0.972,220,0.986,"ZK.93423, bentazepam",0.0123337350737254,0.0061230850587888,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.75211,1.81,0.00248,271,0.114,"PFI.1, I.BET151, OTX015, JQ1...., bromosporine",2.60554831917378,0.943095148663527,TRUE
+"HCC15","Pearson.est","calcium channel blocker",0.51456,1.22,0.225,579,0.561,"mibefradil, penfluridol, carboxyamidotriazole, pranidipine, SR.33805, tetrandrine, efonidipine.monoethanolate",0.647817481888638,0.251037138743839,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.58015,1.36,0.11,450,0.614,"SB.225002, UNBS.5162, PF.04136309, MK.0812, RS.504393",0.958607314841775,0.211831628858832,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.37946,0.892,0.621,578,0.913,"indisulam, arcyriaflavin.a, BMS.387032, PHA.793887, dinaciclib, AT.7519, TG.02, JNJ.7706621, indirubin, R547, P276.00",0.20690839982342,0.039529222465701,FALSE
+"HCC15","Pearson.est","CHK inhibitor",0.47034,1.1,0.359,229,0.666,"PF.477736, SB.218078",0.444905551421681,0.176525770829699,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",0.15596,0.366,0.999,813,0.999,"curcumin, piroxicam, pterostilbene, sulfasalazine, FR.122047, suxibuzone, meloxicam, amfenac, tepoxalin, AM.404, metoxibutropate, ketoprofen",0.000434511774017692,0.000434511774017692,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",-0.56262,-1.65,0.0427,1248,0.263,"clotrimazole, itraconazole, metyrapone, eplerenone",1.36957212497498,0.580044251510242,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",0.31065,0.744,0.812,434,1,"estramustine, melphalan, satraplatin, cisplatin, mitomycin.c",0.0904439707588247,0,FALSE
+"HCC15","Pearson.est","DNA inhibitor",0.33459,0.789,0.756,676,0.984,"valrubicin, chlorambucil, melphalan, pibenzimol, teroxirone, bendamustine, mechlorethamine, primaquine, tirapazamine, sangivamycin, oxaliplatin, busulfan",0.121478204498793,0.00700490156865849,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.61969,1.46,0.0687,414,0.478,"fdcyd, SGI.1027, disulfiram, azacitidine",1.16304326294045,0.320572103387881,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.60732,1.43,0.0763,485,0.458,"cephalomannine, adefovir.dipivoxil, menadione, cidofovir, trifluridine, idoxuridine",1.11747546204512,0.339134521996131,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",0.22956,0.539,0.967,664,1,"floxuridine, enocitabine, cisplatin, mitomycin.c, estramustine.phosphate, artemisinin, anisomycin, altretamine",0.0145735259169983,0,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",-0.27274,-0.788,0.681,1187,1,"remoxipride, piperacetazine, raclopride, ziprasidone, clebopride, acetophenazine, oxiperomide",0.166852888087215,0,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.35436,-0.972,0.456,1327,0.784,"ethinyl.estradiol, equol",0.341035157335565,0.105683937315562,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",0.24712,0.58,0.935,457,1,"danazol, fulvestrant",0.0291883891274822,0,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.48614,1.15,0.304,374,0.613,"dovitinib, erdafitinib, regorafenib, PD.173074, MK.2461",0.517126416391246,0.212539525481585,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.54249,1.27,0.17,433,0.548,"dovitinib, GTP.14564, lestaurtinib, tyrphostin.AG.1296, tozasertib, ENMD.2076, pacritinib, quizartinib, KW.2449, TG.101348, TG.02, sunitinib",0.769551078621726,0.261219441515631,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.42288,-1.24,0.215,1303,0.601,"prednisolone.acetate, flumethasone, fluticasone.propionate, fluocinolone.acetonide, beclomethasone.dipropionate, hydrocortisone",0.667561540084395,0.22112552799726,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",0.29186,0.695,0.839,277,1,"ACDPP, felbamate, CGP.37849",0.0762380391712997,0,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.3692,0.869,0.651,22,0.934,"AZD2858",0.186419011431808,0.0296531237699066,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",0.52399,1.23,0.211,142,0.563,"danusertib, lestaurtinib",0.675717544702307,0.249491605148654,FALSE
+"HCC15","Pearson.est","HCV inhibitor",0.39243,0.914,0.586,443,0.915,"narlaprevir, mericitabine",0.232102383981909,0.0385789059335517,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.74271,1.74,0.00357,212,0.114,"R306465, PCI.24781, M.344, SB.939, givinostat, trichostatin.a, entinostat, ACY.1215, dacinostat, vorinostat, RGFP966, AR.42, belinostat, resminostat, nexturastat.a, scriptaid, chidamide, pyroxamide",2.44733178388781,0.943095148663527,TRUE
+"HCC15","Pearson.est","histamine receptor antagonist",0.23387,0.551,0.961,915,1,"chloropyramine, cyproheptadine, epinastine, astemizole, tecastemizole, ICI.162846, ebastine, lafutidine, tiotidine, cimetidine, pheniramine, zolantidine, levocetirizine",0.0172766123314547,0,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",-0.45697,-1.35,0.158,1373,0.481,"lovastatin, simvastatin",0.801342913045577,0.317854923626168,FALSE
+"HCC15","Pearson.est","HSP inhibitor",0.52679,1.26,0.188,492,0.518,"NMS.E973, SNX.5422, SNX.2112, KW.2478, NVP.AUY922, BIIB021, PU.H71, ganetespib",0.72584215073632,0.285670240254767,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.41719,0.983,0.504,563,0.836,"lestaurtinib, WHI.P154, AZ960, baricitinib, tozasertib, AT.9283, pacritinib, TG.101348, TG.02, PRT062070, TG.101209, LY2784544",0.297569463554475,0.0777937225609836,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.25092,0.595,0.93,718,1,"OSI.930, regorafenib, pazopanib, sunitinib, motesanib, midostaurin, masitinib, vatalanib, cediranib, lenvatinib, sorafenib",0.0315170514460649,0,FALSE
+"HCC15","Pearson.est","MDM inhibitor",-0.40695,-1.15,0.257,1251,0.719,"RITA, AMG.232, CGM097",0.590066876668705,0.143271109617117,FALSE
+"HCC15","Pearson.est","MEK inhibitor",-0.37439,-1.12,0.342,535,0.649,"PD.318088, U.0126, PD.198306, MEK162, arctigenin, MEK1.2.inhibitor, PD.98059, PD.0325901, nobiletin, BIX.02188, TAK.733, PD.184352, AZD8330, Ro.4987655, selumetinib, cobimetinib, refametinib, trametinib, AS.703026",0.465973893943865,0.187755303199631,FALSE
+"HCC15","Pearson.est","MET inhibitor",0.3856,0.918,0.58,57,0.931,"AMG458",0.236572006437063,0.0310503190186574,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.64551,1.52,0.0473,320,0.442,"vinblastine, vinflunine, D.64131, cabazitaxel, podophyllotoxin, colchicine, triclabendazole",1.32513885926219,0.354577730650908,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",0.47276,1.12,0.318,522,0.662,"GSK2126458, PF.04691502, deforolimus, PF.05212384, OSI.027, PI.103, PKI.179, AZD8055, SB.2343, torin.1, AZD2014, ku.0063794, PP242, XL388",0.497572880015567,0.1791420105603,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.55577,1.31,0.146,479,0.575,"EVP4593, curcumin, parthenolide, BAY.11.7082, bindarit, Ro.106.9920, tyloxapol, betulinic.acid",0.835647144215563,0.24033215531037,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",-0.24202,-0.686,0.851,349,0.891,"trimebutine, spiradoline, salvinorin.a, BW.180C, cebranopadol, ADL5859",0.0700704399154121,0.0501222959631252,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",0.44171,1.04,0.421,325,0.755,"talmapimod, SB.239063",0.375717904164332,0.122053048370812,FALSE
+"HCC15","Pearson.est","PARP inhibitor",0.54456,1.28,0.16,327,0.552,"talazoparib, niraparib, PJ.34, AZD2461, olaparib",0.795880017344075,0.258060922270801,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.22912,0.53,0.964,745,1,"dovitinib, axitinib, regorafenib, pazopanib, SU014813, sunitinib, nintedanib, motesanib, trapidil, masitinib, vatalanib, lenvatinib, sorafenib, linifanib, crenolanib",0.0159229660971692,0,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.5427,1.28,0.155,419,0.552,"CID.5458317, sodium.stibogluconate, menadione, mycophenolate.mofetil, bis.maltolato.oxovanadium.IV., alexidine",0.809668301829709,0.258060922270801,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",0.36838,0.862,0.669,700,0.926,"enoximone, avanafil, papaverine, cilostamide, GSK256066, EMD.53998, anagrelide",0.174573882232177,0.0333890133180656,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",0.50487,1.19,0.249,477,0.586,"CUDC.907, GSK2126458, PF.04691502, PF.05212384, buparlisib, BGT226, AZD6482, PI.103, PKI.179, taselisib, pilaralisib, GDC.0941, SB.2343, ZSTK.474, YM.201636",0.603800652904264,0.232102383981909,FALSE
+"HCC15","Pearson.est","PLK inhibitor",0.8626,2.03,0,205,0.00767,"BI.2536, volasertib, rigosertib, NMS.1286937, HMN.214, GW.843682X, GSK461364",Inf,2.11520463605102,TRUE
+"HCC15","Pearson.est","potassium channel blocker",-0.32247,-0.943,0.523,465,0.793,"mepivacaine, ML133, dofetilide, oleoylethanolamide, meglitinide, ibutilide",0.281498311132726,0.100726812682396,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",0.39903,0.937,0.549,365,0.915,"ciprofibrate, pterostilbene",0.260427655549908,0.0385789059335517,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",0.3528,0.836,0.701,297,0.951,"tanaproget, danazol",0.154281982033341,0.0218194830625861,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.28564,0.67,0.892,690,1,"MG.132, carfilzomib, ONX.0914, oprozomib, delanzomib",0.0496351456238769,0,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.66551,1.59,0.0337,170,0.317,"anguidine, azomycin..2.nitroimidazole., homoharringtonine, bruceantin, thiostrepton, puromycin, tedizolid.phosphate, harringtonine",1.47237009912866,0.498940737782249,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.3562,0.831,0.713,607,0.939,"tyrphostin.A9, mubritinib, PP.121, NVP.TAE226, CP.724714",0.146910470148134,0.0273344077338891,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.56771,1.33,0.13,508,0.557,"TAK.632, RAF265, regorafenib, PLX.4720, AZ.628, GDC.0879, dabrafenib, SB.590885, CEP.32496",0.886056647693163,0.254144804826271,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",-0.26818,-0.766,0.76,1433,0.948,"vandetanib",0.119186407719209,0.0231916626619338,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",0.55668,1.28,0.164,618,0.552,"adarotene, fenretinide, bexarotene, adapalene, AM.580, CD.437, LE.135",0.785156151952302,0.258060922270801,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.50173,1.18,0.269,429,0.588,"fludarabine.phosphate, LY2334737, clofarabine, pentostatin, triapine",0.570247719997592,0.230622673923862,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",0.57019,1.33,0.131,98,0.557,"aripiprazole, pardoprunox",0.882728704344236,0.254144804826271,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",0.46909,1.1,0.358,370,0.666,"aripiprazole, SB.200646, sertindole, lurasidone, lerisetron",0.446116973356126,0.176525770829699,FALSE
+"HCC15","Pearson.est","sodium channel blocker",0.28152,0.662,0.862,609,1,"brivaracetam, benzethonium, lappaconite, mexiletine, mepivacaine, triamterene, quinidine",0.0644927341752872,0,FALSE
+"HCC15","Pearson.est","src inhibitor",-0.5108,-1.42,0.117,1445,0.521,"saracatinib, dasatinib",0.931814138253838,0.283162276700476,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",-0.46603,-1.38,0.144,1314,0.507,"lanoconazole, ketoconazole, sulconazole, terconazole",0.84163750790475,0.294992040666664,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.24709,0.582,0.95,708,1,"adaprev, D.4476, LY2109761, SB.431542",0.0222763947111523,0,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.49429,1.15,0.297,493,0.613,"doxifluridine, raltitrexed, trifluridine, carmofur",0.527243550682788,0.212539525481585,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",0.53439,1.26,0.171,467,0.518,"doxorubicin, valrubicin, epirubicin, daunorubicin, etoposide, dexrazoxane, teniposide, beta.lapachone, voreloxin, etoposide.phosphate, nemorubicin, mitoxantrone, topotecan, SN.38, irinotecan, genz.644282, amonafide, camptothecin",0.767003889607846,0.285670240254767,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.73581,1.74,0.0159,285,0.114,"taltobulin, vincristine, vinorelbine, albendazole, vinblastine, fosbretabulin, vindesine, parbendazole, dolastatin.10, nocodazole, fenbendazole, ABT.751, flubendazole, BNC105, KX2.391, CYT.997, plinabulin, paclitaxel, combretastatin.A.4, verubulin, mebendazole, podophyllotoxin, oxibendazole",1.79860287567955,0.943095148663527,TRUE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.32283,0.759,0.797,211,1,"tyrphostin.A9, GTP.14564, regorafenib, tivantinib, bafetinib, UNC2250, mubritinib",0.0985416786038876,0,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.27293,0.644,0.896,433,1,"OSI.930, dovitinib, RAF265, axitinib, regorafenib, pazopanib, PD.173074, semaxanib, ENMD.2076, MK.2461, SU014813, sunitinib",0.0476919903378748,0,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",-0.65771,-2.02,0.0194,1153,0.119,"tacalcitol, paricalcitol, ercalcitriol, alfacalcidol, doxercalciferol",1.71219827006977,0.924453038607469,TRUE
+"HCC44","Pearson.est","EGFR inhibitor",0.65137,1.96,0,105,0.0897,"tucatinib, poziotinib, osimertinib, AZD8931, dacomitinib, ARRY.334543, CNX.2006, CUDC.101, BMS.599626, CP.724714, canertinib, BMS.690514, afatinib, WZ8040, lapatinib, neratinib, gefitinib, WZ.4002",Inf,1.04720755695591,TRUE
+"HCC44","Pearson.est","Abl kinase inhibitor",-0.62716,-1.49,0.0534,1051,0.411,"ponatinib, metatinib, GZD824, nilotinib, flumatinib, dasatinib, tozasertib, KW.2449, bosutinib",1.27245874297144,0.386158178123931,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",-0.50033,-1.2,0.231,848,0.695,"nicotine, tremorine, xanomeline, pilocarpine",0.636388020107856,0.158015195409886,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.37815,-0.903,0.592,1064,0.87,"iododexetimide, methscopolamine",0.22767829327708,0.0604807473813815,FALSE
+"HCC44","Pearson.est","adenosine receptor antagonist",0.62099,1.86,0,40,0.0988,"CGS.15943, MRS.1220, SCH.58261",Inf,1.00524305541237,TRUE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.47449,-1.14,0.293,1059,0.662,"isoetharine, A61603, isoxsuprine, norepinephrine, epinephrine, buphenine, clenbuterol",0.533132379645891,0.1791420105603,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",-0.35574,-0.836,0.695,1165,0.882,"vincamine, propranolol, carvedilol, levobunolol, idazoxan",0.158015195409886,0.0545314148681803,FALSE
+"HCC44","Pearson.est","AKT inhibitor",0.39214,1.19,0.23,133,0.595,"uprosertib, GDC.0068, GSK2110183, MK.2206",0.638272163982407,0.22548303427145,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.46079,-1.1,0.327,1062,0.628,"AZD3463, AP26113, crizotinib, lorlatinib",0.485452247339714,0.202040356262804,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",-0.51779,-1.23,0.211,994,0.642,"bicalutamide, flutamide, nilutamide, cyproterone.acetate",0.675717544702307,0.192464971931147,FALSE
+"HCC44","Pearson.est","antioxidant",-0.4681,-1.12,0.305,675,0.642,"trolox, benfotiamine, rutin, taurine, chlorogenic.acid, mesna",0.515700160653214,0.192464971931147,FALSE
+"HCC44","Pearson.est","AP inhibitor",-0.37328,-0.897,0.611,651,0.863,"idronoxil, birinapant, GDC.0152, LCL.161",0.213958789757446,0.0639892042847904,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",-0.51157,-1.23,0.206,1358,0.642,"ouabain, digitoxigenin, digitoxin",0.686132779630847,0.192464971931147,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.45528,-1.09,0.357,1293,0.632,"alisertib, MK.8745, PF.03814735, tozasertib, KW.2449, MK.5108, hesperadin",0.447331783887807,0.199282921717615,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.52885,-1.29,0.158,948,0.615,"josamycin, tilmicosin, valnemulin, tedizolid, dirithromycin",0.801342913045577,0.211124884224583,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.55546,-1.32,0.13,1004,0.707,"norfloxacin, lomefloxacin, novobiocin, sparfloxacin, finafloxacin",0.886056647693163,0.150580586203101,FALSE
+"HCC44","Pearson.est","BCL inhibitor",0.26875,0.824,0.667,1061,0.907,"ABT.737, oridonin, HA14.1, venetoclax, navitoclax, obatoclax, gossypol, TW.37",0.175874166083451,0.0423927129399047,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.68021,-1.63,0.0151,1051,0.253,"ponatinib, metatinib, GZD824, nilotinib, flumatinib, dasatinib, tozasertib, bosutinib",1.82102305270683,0.596879478824182,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.25111,-0.597,0.939,999,0.985,"ZK.93423, lorazepam, CGS.20625",0.0273344077338891,0.00656376950238827,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",0.49098,1.53,0.0803,740,0.263,"I.BET151, OTX015, PFI.1, JQ1...., I.BET.762, bromosporine",1.09528445472132,0.580044251510242,FALSE
+"HCC44","Pearson.est","calcium channel blocker",0.25939,0.783,0.729,1075,0.923,"efonidipine.monoethanolate, fendiline, SR.33805, mibefradil, SKF.96365, pranidipine, penfluridol, tetrandrine, cinnarazine, carboxyamidotriazole",0.137272471682025,0.0347982989740879,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.31789,-0.762,0.786,686,0.943,"PF.04136309, navarixin, MK.0812, UNBS.5162, RS.504393",0.104577453960592,0.0254883072626717,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.49302,-1.17,0.263,1047,0.633,"PHA.793887, CR8..R., JNJ.7706621, R547, BMS.265246, kenpaullone, aminopurvalanol.a, abemaciclib, alvocidib, PHA.848125, palbociclib, AZD5438",0.580044251510242,0.198596289982645,FALSE
+"HCC44","Pearson.est","CHK inhibitor",-0.48915,-1.17,0.269,1246,0.633,"AZD7762, SCH.900776, LY2606368",0.570247719997592,0.198596289982645,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.25133,-0.607,0.935,611,0.995,"piroxicam, meloxicam, acetylsalicylsalicylic.acid, amfenac, FK.3311, metoxibutropate, phenylbutazone, FR.122047, aspirin, phenazone, tepoxalin, ramifenazone, ketoprofen, suxibuzone, indoprofen",0.0291883891274822,0.00217691925427455,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.46565,-1.12,0.311,671,0.642,"itraconazole, metyrapone, morin, clotrimazole, PF.4981517, eplerenone, cobicistat",0.507239610973163,0.192464971931147,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",-0.50519,-1.19,0.239,820,0.634,"streptozotocin, ifosfamide, TH.302, dacarbazine, mitomycin.c, dianhydrogalactitol, melphalan, satraplatin, temozolomide, carmustine, cisplatin, carboplatin",0.621602099051862,0.197910742118267,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.40504,-0.974,0.506,807,0.819,"primaquine, nimorazole, tirapazamine, sangivamycin, teroxirone, chlorambucil, melphalan, valrubicin, carmustine, carboplatin",0.295849483160201,0.0867160982395816,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.48851,-1.16,0.289,1364,0.636,"decitabine",0.539102157243452,0.196542884351586,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.45867,-1.11,0.32,1111,0.625,"idoxuridine, trifluridine, foscarnet",0.494850021680094,0.204119982655925,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",-0.54524,-1.3,0.152,924,0.625,"artesunate, artemisinin, mitomycin.c, nelarabine, anisomycin, cisplatin, floxuridine, CB.10.277, cyclocytidine",0.818156412055227,0.204119982655925,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.20333,-0.486,0.985,1226,1,"isofloxythepin, piperacetazine, raclopride",0.00656376950238827,0,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",-0.50864,-1.23,0.196,894,0.642,"estradiol.cypionate, estrone, estradiol, ethinyl.estradiol, PPT",0.707743928643524,0.192464971931147,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",0.36612,1.13,0.243,170,0.643,"raloxifene, danazol",0.614393726401688,0.191789027075778,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",0.36231,1.09,0.344,927,0.657,"PD.173074, orantinib, lenvatinib, dovitinib, erdafitinib, lucitanib, AZD4547, regorafenib, nintedanib, MK.2461",0.46344155742847,0.182434630440219,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.44517,-1.07,0.377,822,0.659,"lestaurtinib, tandutinib, pacritinib, quizartinib, tyrphostin.AG.1296, ponatinib, midostaurin, tozasertib, KW.2449, gilteritinib",0.423658649794207,0.18111458540599,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.24454,-0.578,0.96,866,0.98,"dexamethasone.acetate, prednisolone.acetate, halobetasol.propionate, beclomethasone.dipropionate, fluorometholone, fluocinolone.acetonide, methylprednisolone, difluprednate, flumethasone, fluticasone.propionate",0.0177287669604316,0.00877392430750515,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",0.23611,0.681,0.883,196,0.907,"CGP.37849, MTPG, CPP, IEM1754",0.0540392964224314,0.0423927129399047,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.38344,-0.925,0.576,892,0.865,"AZD2858, TWS.119, CHIR.99021, kenpaullone, tideglusib",0.239577516576788,0.0629838925351858,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.47499,-1.13,0.3,822,0.662,"lestaurtinib, GSK1904529A, danusertib, AZD3463, GSK1838705A, PHA.848125",0.522878745280338,0.1791420105603,FALSE
+"HCC44","Pearson.est","HCV inhibitor",-0.59475,-1.43,0.0761,1140,0.467,"Ro.9187, daclatasvir, mericitabine",1.11861534322943,0.330683119433888,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",0.39447,1.21,0.223,789,0.635,"scriptaid, SB.939, R306465, vorinostat, PCI.24781, M.344, JNJ.26481585, ACY.1215, entinostat, givinostat, nexturastat.a, RGFP966, tacedinaline, NSC.3852, romidepsin, pyroxamide, AR.42, panobinostat, dacinostat, RG2833, chidamide, resminostat, mocetinostat, belinostat",0.651695136951839,0.197226274708024,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",-0.29664,-0.721,0.829,1153,0.942,"tiotidine, cimetidine, nizatidine, BF2.649, pheniramine",0.0814454694497265,0.0259490972071227,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",-0.78833,-1.87,0.00116,1217,0.128,"simvastatin, atorvastatin, pitavastatin, fluvastatin, mevastatin",2.93554201077308,0.892790030352132,TRUE
+"HCC44","Pearson.est","HSP inhibitor",-0.70256,-1.68,0.0127,1162,0.206,"XL888, NMS.E973, SNX.5422, SNX.2112, BIIB021, ganetespib, NVP.AUY922, PU.H71",1.89619627904404,0.686132779630847,TRUE
+"HCC44","Pearson.est","JAK inhibitor",-0.43277,-1.03,0.432,910,0.711,"AZD1480, pacritinib, TG.101209, CEP.33779, baricitinib, ruxolitinib, AZ960, filgotinib, tozasertib, WHI.P154",0.364516253185088,0.148130399270234,FALSE
+"HCC44","Pearson.est","KIT inhibitor",-0.36232,-0.862,0.676,718,0.873,"cediranib, pazopanib, motesanib, regorafenib, tandutinib, telatinib, KI.8751, midostaurin, dasatinib",0.170053304058364,0.0589857562944303,FALSE
+"HCC44","Pearson.est","MDM inhibitor",0.2337,0.671,0.848,1111,0.873,"RITA, serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3",0.0716041477432862,0.0589857562944303,FALSE
+"HCC44","Pearson.est","MEK inhibitor",-0.36344,-0.875,0.644,602,0.868,"PD.198306, AS.703026, PD.318088, AZD8330, TAK.733, U.0126, PD.98059, trametinib, MEK162, arctigenin, PD.0325901, nobiletin, refametinib, Ro.4987655, PD.184352",0.191114132640188,0.0614802748235081,FALSE
+"HCC44","Pearson.est","MET inhibitor",-0.7618,-1.81,0.00462,1332,0.128,"PF.04217903, PHA.665752, LY2801653",2.33535802444387,0.892790030352132,TRUE
+"HCC44","Pearson.est","microtubule inhibitor",-0.5274,-1.26,0.172,799,0.663,"triclabendazole, cytochalasin.b, secnidazole, podophyllotoxin, cabazitaxel, vinflunine, vinblastine, D.64131",0.764471553092451,0.178486471595227,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",0.23451,0.706,0.854,1115,0.982,"PF.05212384, OSI.027, AZD2014, WYE.125132, XL388, GSK2126458, PF.04691502, SB.2343, PKI.179, temsirolimus, everolimus, PI.103, torin.2, WYE.354, sirolimus, GDC.0980, AZD8055, LY303511, voxtalisib, ku.0063794, torin.1, deforolimus, PP242, MLN0128, WAY.600, NVP.BEZ235, LY3023414, palomid.529",0.068542129310995,0.00788851221305034,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",0.33098,1.02,0.369,111,0.74,"tyloxapol, parthenolide...., Ro.106.9920",0.43297363384094,0.130768280269024,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.63672,-1.53,0.0356,1224,0.365,"salvinorin.a, trimebutine, spiradoline",1.44855000202712,0.437707135543525,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",0.22831,0.683,0.862,1119,0.956,"talmapimod, TAK.715, skepinone.l, SB.239063, VX.702, SB.242235, CMPD.1",0.0644927341752872,0.0195421077238999,FALSE
+"HCC44","Pearson.est","PARP inhibitor",-0.4962,-1.19,0.259,927,0.634,"AZD2461, AG.14361, niraparib, E7449, talazoparib, olaparib",0.586700235918748,0.197910742118267,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.40254,-0.969,0.52,780,0.809,"pazopanib, motesanib, trapidil, regorafenib, tandutinib, nintedanib, telatinib, ponatinib, KI.8751, dasatinib, crenolanib, CP.673451",0.283996656365201,0.0920514783877277,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",-0.26797,-0.638,0.919,906,0.989,"BVT.948, mycophenolic.acid, AS.1949490, GSK2830371",0.0366844886138887,0.0048037084028206,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.38736,-0.929,0.582,1121,0.877,"EMD.53998, YM.976, zardaverine",0.235077015350112,0.0570004066339595,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",0.26572,0.836,0.594,108,0.945,"taselisib, PF.05212384, CUDC.907, alpelisib, pilaralisib, CH5132799",0.226213555018806,0.0245681914907371,FALSE
+"HCC44","Pearson.est","PLK inhibitor",-0.58084,-1.4,0.0959,930,0.506,"NMS.1286937, BI.2536, GW.843682X, GSK461364, volasertib, rigosertib",1.01818139282934,0.295849483160201,FALSE
+"HCC44","Pearson.est","potassium channel blocker",-0.73145,-1.75,0.00804,1158,0.152,"meglitinide, dofetilide, oleoylethanolamide, ML133, ibutilide",2.09474395125155,0.818156412055227,TRUE
+"HCC44","Pearson.est","PPAR receptor agonist",0.30997,0.909,0.518,128,0.853,"pterostilbene, S26948",0.285670240254767,0.069050968832477,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",-0.31466,-0.761,0.794,1180,0.927,"nomegestrol.acetate, dienogest",0.100179497572904,0.0329202658555029,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",-0.45951,-1.11,0.316,1200,0.625,"bortezomib, MG.132, ixazomib",0.500312917381596,0.204119982655925,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",-0.33869,-0.804,0.757,1301,0.915,"emetine, cycloheximide, mercaptopurine",0.120904120499927,0.0385789059335517,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.3213,0.957,0.51,48,0.816,"BMS.599626, CP.724714",0.292429823902064,0.0883098412461389,FALSE
+"HCC44","Pearson.est","RAF inhibitor",-0.33067,-0.787,0.745,850,0.924,"regorafenib, PLX.4720, GDC.0879, LGX818, RAF265",0.127843727251707,0.0343280287798933,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.27527,-0.657,0.903,641,0.99,"apatinib, regorafenib, cabozantinib",0.0443122496864942,0.00436480540245009,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",0.53751,1.69,0.0217,152,0.173,"adarotene, fenretinide, CD.437, bexarotene",1.66354026615147,0.761953896871205,TRUE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.54032,-1.3,0.16,1212,0.625,"triapine, gemcitabine, fludarabine.phosphate, clofarabine",0.795880017344075,0.204119982655925,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.49721,-1.19,0.217,1258,0.634,"aripiprazole, SR.57227A",0.66354026615147,0.197910742118267,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.36528,-0.885,0.626,953,0.868,"lerisetron, SB.228357, SB.216641, pirenperone, aripiprazole, RS.16566",0.20342566678957,0.0614802748235081,FALSE
+"HCC44","Pearson.est","sodium channel blocker",-0.36466,-0.857,0.673,1007,0.863,"ajmaline, butamben, oxcarbazepine, quinidine, cibenzoline",0.171984935776023,0.0639892042847904,FALSE
+"HCC44","Pearson.est","src inhibitor",-0.59672,-1.43,0.06,1340,0.467,"dasatinib, bosutinib, PP.2",1.22184874961636,0.330683119433888,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",-0.38134,-0.92,0.561,592,0.855,"ketoconazole, sulconazole, posaconazole, lanoconazole, chlormidazole",0.251037138743839,0.0680338852718274,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",0.83634,2.45,0,242,0.00915,"SB.431542, SB.525334, LY2109761, adaprev, repsox, D.4476",Inf,2.03857890593355,TRUE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.53981,-1.3,0.135,1025,0.625,"ftorafur, trifluridine, doxifluridine, raltitrexed",0.869666231504994,0.204119982655925,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",-0.66926,-1.6,0.0289,1168,0.265,"valrubicin, irinotecan, amonafide, camptothecin, nemorubicin, etoposide.phosphate, mitoxantrone, exatecan.mesylate, etoposide, voreloxin, amsacrine, teniposide, genz.644282, idarubicin, topotecan, rubitecan, TAS.103, SN.38",1.53910215724345,0.576754126063192,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.44242,-1.05,0.408,1071,0.686,"KX2.391, vindesine, parbendazole, podophyllotoxin, verubulin, paclitaxel, docetaxel, epothilone.b, fosbretabulin, vinblastine, epothilone.d, BNC105",0.38933983691012,0.163675884293248,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.32014,-0.751,0.817,1065,0.923,"tivantinib, AMG.208, cabozantinib, UNC2250, NVP.TAE226, aminopurvalanol.a, dasatinib",0.0877779434675845,0.0347982989740879,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",-0.15056,-0.362,1,827,0.999,"motesanib, regorafenib, nintedanib, MGCD.265, MK.2461, telatinib, KI.8751, foretinib, cabozantinib, RAF265, SAR131675",0,0.000434511774017692,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",0.47351,1.5,0.0606,113,0.25,"maxacalcitol, paricalcitol",1.21752737583371,0.602059991327962,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.84454,2.34,0,64,0.00999,"osimertinib, BMS.690514, afatinib, AZD8931, BMS.599626, canertinib, poziotinib, lapatinib, ARRY.334543, tucatinib, dacomitinib, AST.1306, CUDC.101, neratinib, erlotinib, WZ.4002, WZ8040, pelitinib, PD.168393, XL.647, gefitinib, BIBU.1361, CP.724714, vandetanib, PD.153035, AEE788, rociletinib",Inf,2.00043451177402,TRUE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.40379,-0.964,0.513,1111,0.751,"metatinib, ponatinib, tozasertib, GZD824, nilotinib",0.289882634888184,0.124360062995832,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.27613,-0.67,0.865,602,1,"tremorine, nicotine, pilocarpine, oxiracetam, xanomeline",0.0629838925351858,0,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",-0.52362,-1.25,0.198,933,0.468,"darifenacin, diphemanil, methscopolamine, iododexetimide",0.703334809738469,0.329754146925876,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",0.66956,1.8,0.017,37,0.105,"CGS.15943, MRS.1220, SCH.58261",1.76955107862173,0.978810700930062,TRUE
+"H1299","Pearson.est","adrenergic receptor agonist",-0.24015,-0.579,0.936,827,0.974,"buphenine, lidamidine, norepinephrine, clenbuterol, xylazine",0.0287241512618947,0.0114410431213845,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",-0.27809,-0.659,0.868,851,0.994,"naftidrofuryl, propranolol, metoprolol, oxprenolol, levobunolol, vincamine, carvedilol, idazoxan",0.0614802748235081,0.00261361560268669,FALSE
+"H1299","Pearson.est","AKT inhibitor",0.71864,1.94,0.0157,125,0.0844,"GDC.0068, AZD5363, GSK2110183, uprosertib, CCT128930",1.80410034759077,1.07365755337434,TRUE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.21507,-0.521,0.979,1085,0.972,"crizotinib, lorlatinib",0.00921730819686218,0.0123337350737254,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",-0.4668,-1.12,0.328,803,0.586,"cyproterone.acetate, flutamide, nilutamide",0.484126156288321,0.232102383981909,FALSE
+"H1299","Pearson.est","antioxidant",0.35298,1.01,0.421,939,0.658,"trolox, benfotiamine, mesna, taurine, rutin, chlorogenic.acid",0.375717904164332,0.181774106386044,FALSE
+"H1299","Pearson.est","AP inhibitor",-0.6823,-1.65,0.0214,1192,0.201,"birinapant, LCL.161, GDC.0152, idronoxil",1.66958622665081,0.696803942579511,TRUE
+"H1299","Pearson.est","ATPase inhibitor",-0.77125,-1.84,0.00381,1256,0.0567,"thonzonium, oligomycin.a, evodiamine, ouabain, digitoxin, digitoxigenin, k.strophanthidin, digoxin",2.41907502432438,1.24641694110709,TRUE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.59139,-1.41,0.101,997,0.334,"KW.2449, CCT137690, GSK1070916, aurora.a.inhibitor.i, alisertib, SNS.314, MK.8745, TAK.901, AMG900, PF.03814735, barasertib.HQPA, barasertib, hesperadin, danusertib, tozasertib, MK.5108",0.995678626217357,0.476253533188435,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.41408,-1,0.474,806,0.718,"josamycin, tilmicosin, radezolid, tedizolid, valnemulin",0.324221658325915,0.1438755557577,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.41106,-0.987,0.483,1223,0.725,"sparfloxacin, lomefloxacin",0.316052869248488,0.139661993429006,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.31768,-0.75,0.785,1140,0.958,"TW.37, gossypol",0.105130343254747,0.0186344909214556,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.62225,-1.48,0.0533,1111,0.319,"metatinib, ponatinib, tozasertib, GZD824, nilotinib",1.27327279097343,0.496209316942819,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",-0.25011,-0.596,0.941,869,1,"ZK.93423, indiplon, CGS.20625, bentazepam",0.0264103765727431,0,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",0.36333,0.999,0.38,187,0.632,"PFI.1, I.BET151",0.42021640338319,0.199282921717615,FALSE
+"H1299","Pearson.est","calcium channel blocker",-0.29862,-0.718,0.832,1302,0.982,"penfluridol, carboxyamidotriazole",0.0798766737092761,0.00788851221305034,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.3578,-0.853,0.653,992,0.915,"MK.0812, SB.225002, UNBS.5162",0.185086818724926,0.0385789059335517,FALSE
+"H1299","Pearson.est","CDK inhibitor",-0.35365,-0.845,0.666,820,0.909,"alvocidib, AT.7519, aminopurvalanol.a, P276.00, AZD5438, BMS.387032, kenpaullone, BMS.265246, palbociclib, abemaciclib, dinaciclib, R547, PHA.848125, PHA.793887",0.176525770829699,0.0414361167780325,FALSE
+"H1299","Pearson.est","CHK inhibitor",-0.31622,-0.768,0.772,819,0.952,"AZD7762, SB.218078, SCH.900776, LY2606368",0.112382699664264,0.0213630516155257,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",-0.23908,-0.566,0.946,917,0.966,"amfenac, piroxicam, sulfasalazine, AM.404, indoprofen, metoxibutropate, suxibuzone, tepoxalin",0.0241088635982073,0.0150228735845067,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",-0.55642,-1.34,0.127,926,0.387,"itraconazole, eplerenone, clotrimazole, cobicistat, metyrapone",0.896196279044043,0.412289034981089,FALSE
+"H1299","Pearson.est","DNA alkylating agent",-0.47786,-1.13,0.295,772,0.602,"streptozotocin, satraplatin, mitomycin.c, cyclophosphamide, estramustine, TH.302, temozolomide, melphalan, carmustine, dianhydrogalactitol, carboplatin, cisplatin",0.530177984021837,0.220403508742175,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.55085,-1.32,0.153,1157,0.405,"melphalan, sangivamycin, carmustine, carboplatin, chlorambucil, valrubicin",0.815308569182401,0.392544976785331,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",0.321,0.859,0.621,171,0.748,"SGI.1027, fdcyd, azacitidine",0.20690839982342,0.126098402135539,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",-0.56752,-1.34,0.131,1127,0.387,"trifluridine, cephalomannine, foscarnet, menadione",0.882728704344236,0.412289034981089,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",-0.49073,-1.18,0.255,817,0.554,"enocitabine, mitomycin.c, azodicarbonamide, anisomycin, nelarabine, artemisinin, floxuridine, altretamine, CB.10.277, cyclocytidine, cisplatin",0.593459819566045,0.25649023527157,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",0.23102,0.646,0.905,145,0.934,"lurasidone, oxiperomide, remoxipride, clebopride",0.0433514207947967,0.0296531237699066,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",-0.24099,-0.579,0.93,690,0.974,"estrone, estradiol.cypionate, estradiol, ethinyl.estradiol, PPT",0.0315170514460649,0.0114410431213845,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",0.38195,1.05,0.392,87,0.633,"clomifene, raloxifene",0.406713932979543,0.198596289982645,FALSE
+"H1299","Pearson.est","FGFR inhibitor",-0.67164,-1.62,0.0232,1177,0.215,"nintedanib, MK.2461, regorafenib, lenvatinib, dovitinib, erdafitinib",1.6345120151091,0.667561540084395,TRUE
+"H1299","Pearson.est","FLT3 inhibitor",-0.46666,-1.13,0.303,866,0.602,"midostaurin, TG.101348, lestaurtinib, KW.2449, sunitinib, ponatinib, sorafenib, tyrphostin.AG.1296, dovitinib, tozasertib, gilteritinib",0.518557371497695,0.220403508742175,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",0.26801,0.766,0.763,183,0.862,"hydrocortisone, triamcinolone.acetonide, betamethasone, ciclesonide, fludroxycortide",0.11747546204512,0.0644927341752872,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.3749,1.07,0.335,328,0.644,"latrepirdine, kynurenic.acid, IEM1754, JNJ.16259685, diazooxonorleucine, MTPG, CGP.37849",0.474955192963155,0.191114132640188,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.27692,0.751,0.803,103,0.842,"LY2090314, indirubin",0.095284454721319,0.0746879085003505,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",-0.43285,-1.05,0.408,1310,0.675,"PHA.848125, danusertib",0.38933983691012,0.170696227168975,FALSE
+"H1299","Pearson.est","HCV inhibitor",-0.50682,-1.21,0.229,1268,0.531,"Ro.9187, mericitabine",0.640164517660112,0.274905478918531,FALSE
+"H1299","Pearson.est","HDAC inhibitor",0.31797,0.922,0.558,275,0.724,"JNJ.26481585, M.344, R306465, SB.939, PCI.24781, mocetinostat, vorinostat, scriptaid, panobinostat, tacedinaline",0.253365801062421,0.140261433802853,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",-0.36718,-0.876,0.647,1075,0.895,"cimetidine, pheniramine, ICI.162846, tiotidine, BF2.649, lafutidine",0.1890957193313,0.048176964684088,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",-0.92619,-2.22,0,1413,0,"fluvastatin, pitavastatin, atorvastatin, mevastatin",Inf,Inf,TRUE
+"H1299","Pearson.est","HSP inhibitor",-0.60298,-1.45,0.0795,1339,0.304,"ganetespib, PU.H71, SNX.2112, NVP.AUY922, NMS.E973",1.09963287134353,0.517126416391246,FALSE
+"H1299","Pearson.est","JAK inhibitor",-0.32679,-0.782,0.746,812,0.951,"TG.101209, AT.9283, AZD1480, TG.101348, PRT062070, lestaurtinib, ruxolitinib, WHI.P154, baricitinib, AZ960, tozasertib",0.127261172527331,0.0218194830625861,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.62171,-1.49,0.0644,1122,0.328,"cediranib, sorafenib, KI.8751, regorafenib, OSI.930, lenvatinib, telatinib, motesanib, pazopanib",1.19111413264019,0.484126156288321,FALSE
+"H1299","Pearson.est","MDM inhibitor",0.55404,1.52,0.0877,15,0.187,"RITA",1.05700040663396,0.728158393463501,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.60757,1.66,0.0494,264,0.14,"trametinib, AS.703026, selumetinib, cobimetinib, AZD8330, TAK.733, MEK1.2.inhibitor, PD.0325901, PD.318088, PD.198306, refametinib",1.30627305107635,0.853871964321762,TRUE
+"H1299","Pearson.est","MET inhibitor",-0.58922,-1.42,0.0758,1258,0.338,"PHA.665752, LY2801653",1.12033079436795,0.471083299722345,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.66218,-1.6,0.0201,1130,0.217,"secnidazole, triclabendazole, podophyllotoxin, D.64131, cabazitaxel, vinflunine, vinblastine",1.69680394257951,0.66354026615147,TRUE
+"H1299","Pearson.est","mTOR inhibitor",-0.24537,-0.582,0.929,586,1,"temsirolimus, everolimus, AZD8055, PF.05212384, PI.103, PP242, PF.04691502, SB.2343, AZD2014, sirolimus, XL388, OSI.027, torin.1, PKI.179, WAY.600, NVP.BEZ235, MLN0128, ku.0063794, LY3023414, deforolimus",0.0319842860063582,0,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.42866,-1.03,0.432,888,0.68,"bindarit, IKK.2.inhibitor.V, BAY.11.7082, BAY.11.7085, EVP4593, betulinic.acid, parthenolide, bortezomib",0.364516253185088,0.167491087293764,FALSE
+"H1299","Pearson.est","opioid receptor agonist",-0.34234,-0.83,0.708,914,0.895,"trimebutine, salvinorin.a, spiradoline",0.149966742310231,0.048176964684088,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",0.58603,1.63,0.0378,355,0.14,"SB.239063, TAK.715, talmapimod, skepinone.l, VX.702, SB.242235",1.42250820016277,0.853871964321762,TRUE
+"H1299","Pearson.est","PARP inhibitor",-0.48475,-1.18,0.237,1119,0.554,"olaparib, AZD2461, AG.14361, talazoparib",0.625251653989896,0.25649023527157,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.61028,-1.45,0.0701,1079,0.304,"axitinib, SU014813, ponatinib, sorafenib, KI.8751, nintedanib, regorafenib, lenvatinib, telatinib, motesanib, crenolanib, dovitinib, pazopanib, CP.673451",1.15428198203334,0.517126416391246,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.49167,-1.17,0.265,1031,0.557,"AS.1949490, BVT.948, menadione, bis.maltolato.oxovanadium.IV., GSK2830371",0.576754126063192,0.254144804826271,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",-0.25295,-0.606,0.927,1050,1,"zardaverine, YM.976, GSK256066",0.0329202658555029,0,FALSE
+"H1299","Pearson.est","PI3K inhibitor",0.22272,0.64,0.913,84,0.897,"taselisib, alpelisib, LY303511, CH5132799",0.039529222465701,0.0472075569559079,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.80575,-1.98,0.00131,1222,0.0241,"NMS.1286937, GSK461364, GW.843682X, BI.2536, volasertib, rigosertib",2.88272870434424,1.61798295742513,TRUE
+"H1299","Pearson.est","potassium channel blocker",-0.62462,-1.49,0.0546,1036,0.328,"ML133, mepivacaine, ibutilide, dofetilide",1.26280735729526,0.484126156288321,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",0.41649,1.15,0.284,79,0.553,"pterostilbene, S26948",0.546681659952962,0.257274868695302,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.28417,-0.688,0.851,924,1,"norgestrel, nomegestrol.acetate, tanaproget, norethindrone",0.0700704399154121,0,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.54181,-1.29,0.174,784,0.408,"ixazomib.citrate, oprozomib, delanzomib, ixazomib, bortezomib, carfilzomib, MG.132",0.7594507517174,0.38933983691012,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.56551,-1.36,0.12,1148,0.386,"puromycin, emetine, thiostrepton, tedizolid.phosphate, anguidine, cycloheximide, homoharringtonine, harringtonine, mercaptopurine",0.920818753952375,0.413412695328245,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.61708,1.72,0.0285,39,0.129,"BMS.599626, CP.724714, AV.412",1.54515513999149,0.889410289700751,TRUE
+"H1299","Pearson.est","RAF inhibitor",-0.57021,-1.39,0.113,876,0.349,"LGX818, dabrafenib, PLX.4720, vemurafenib, SB.590885, sorafenib, regorafenib, TAK.632, RAF265",0.94692155651658,0.45717457304082,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.44006,-1.04,0.432,1001,0.678,"sunitinib, cabozantinib, sorafenib, regorafenib",0.364516253185088,0.168770306132937,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",-0.45906,-1.12,0.323,1227,0.586,"adapalene, LE.135, fenretinide",0.490797477668897,0.232102383981909,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.61119,-1.47,0.0852,1226,0.313,"cladribine, triapine, fludarabine.phosphate, gemcitabine, clofarabine",1.0695604052333,0.504455662453552,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",-0.71659,-1.74,0.00651,1241,0.115,"SR.57227A, pardoprunox, aripiprazole",2.18641901143181,0.939302159646388,TRUE
+"H1299","Pearson.est","serotonin receptor antagonist",-0.46235,-1.11,0.331,1110,0.589,"RS.16566, pirenperone, lerisetron, aripiprazole",0.480172006224281,0.229884705212898,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.54434,-1.3,0.149,1025,0.408,"oxcarbazepine, brivaracetam, mepivacaine, quinidine, butamben, cibenzoline",0.826813731587726,0.38933983691012,FALSE
+"H1299","Pearson.est","src inhibitor",0.52773,1.49,0.0813,25,0.189,"saracatinib, ZM.306416",1.08990945440593,0.723538195826756,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.55249,-1.31,0.16,1323,0.407,"chlormidazole, posaconazole",0.795880017344075,0.39040559077478,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",0.66757,1.89,0.0084,296,0.0833,"SB.431542, D.4476, repsox, LY2109761",2.07572071393812,1.07935499859321,TRUE
+"H1299","Pearson.est","thymidylate synthase inhibitor",-0.4528,-1.1,0.347,1127,0.592,"trifluridine, doxifluridine",0.459670525209126,0.22767829327708,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.78856,-1.91,0.00263,1293,0.0412,"irinotecan, amsacrine, mitoxantrone, rubitecan, nemorubicin, voreloxin, idarubicin, daunorubicin, dexrazoxane, valrubicin, SN.38, etoposide, TAS.103, doxorubicin, epirubicin, etoposide.phosphate, teniposide, topotecan",2.58004425151024,1.38510278396687,TRUE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.64247,-1.53,0.0549,1183,0.31,"combretastatin.A.4, dolastatin.10, fosbretabulin, mebendazole, podophyllotoxin, CYT.997, KX2.391, epothilone.d, docetaxel, vincristine, paclitaxel, verubulin, vinorelbine, taltobulin, vindesine, vinblastine, BNC105",1.26042765554991,0.508638306165727,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",0.3266,0.906,0.544,46,0.709,"BMS.599626, CP.724714, AV.412, vandetanib",0.26440110030182,0.149353764816933,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.34936,-0.831,0.684,1122,0.913,"cediranib, SU014813, sorafenib, KI.8751, nintedanib, MK.2461, regorafenib, OSI.930, lenvatinib, telatinib, motesanib, foretinib, dovitinib, SAR131675, RAF265, pazopanib",0.164943898279884,0.039529222465701,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.87641,2.43,0,131,0.00555,"maxacalcitol, paricalcitol, tacalcitol, alfacalcidol, ercalcitriol",Inf,2.25570701687732,TRUE
+"H1703","Pearson.est","EGFR inhibitor",0.86993,2.3,0,49,0.0206,"canertinib, pelitinib, afatinib, dacomitinib, osimertinib, AZD8931, poziotinib, lapatinib, erlotinib, neratinib, ARRY.334543, BMS.690514, BMS.599626, XL.647, PD.168393, vandetanib, gefitinib, BIBU.1361, tucatinib, icotinib, AST.1306, TAK.285, rociletinib, PD.153035, CUDC.101, WZ.4002, WZ8040, CP.724714",Inf,1.68613277963085,TRUE
+"H1703","Pearson.est","Abl kinase inhibitor",0.41252,1.12,0.325,137,0.808,"ZM.306416, dasatinib, bosutinib",0.488116639021126,0.0925886392254138,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",-0.28447,-0.68,0.878,607,0.966,"tremorine, xanomeline, oxiracetam, nefiracetam, nicotine",0.0565054840938974,0.0150228735845067,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.528,-1.27,0.192,1176,0.535,"iododexetimide, diphemanil, methscopolamine",0.71669877129645,0.271646217978772,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",0.40176,1.07,0.354,88,0.856,"CGS.15943, MRS.1220",0.450996737974212,0.0675262353228468,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",0.27559,0.745,0.761,125,0.921,"epinephrine, methyldopa, isoxsuprine",0.118615343229427,0.0357403698031511,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",-0.30058,-0.725,0.816,994,0.953,"naftidrofuryl, imiloxan, idazoxan, oxprenolol, vincamine, metoprolol, carvedilol",0.0883098412461389,0.0209070993616736,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.60526,1.62,0.0644,235,0.263,"triciribine, uprosertib, AZD5363, palomid.529",1.19111413264019,0.580044251510242,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.46874,1.26,0.199,286,0.638,"NVP.TAE684, brigatinib, GW.788388, CEP.37440, AP26113, AZD3463, SB.505124",0.701146923590293,0.195179321278838,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",-0.50436,-1.2,0.252,996,0.581,"RU.58841, flutamide, nilutamide",0.598599459218456,0.235823867609669,FALSE
+"H1703","Pearson.est","antioxidant",-0.27257,-0.653,0.879,602,0.975,"rutin, benfotiamine, chlorogenic.acid, trolox, taurine",0.0560111249262281,0.0109953843014632,FALSE
+"H1703","Pearson.est","AP inhibitor",-0.50977,-1.2,0.249,758,0.581,"embelin, birinapant, LCL.161, GDC.0152, idronoxil",0.603800652904264,0.235823867609669,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.62319,-1.48,0.0569,1095,0.5,"blebbistatin...., k.strophanthidin, ouabain, evodiamine, NMS.873, digitoxigenin, oligomycin.a, digoxin",1.24488773360493,0.301029995663981,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.53733,-1.3,0.161,1126,0.557,"MK.8745, PHA.680632, TAK.901, AT.9283, danusertib, AMG900, CCT137690, barasertib.HQPA, SNS.314, barasertib, MK.5108",0.79317412396815,0.254144804826271,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45412,-1.1,0.333,1027,0.573,"josamycin, tilmicosin, radezolid, valnemulin",0.47755576649368,0.24184537803261,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.38991,-0.924,0.572,894,0.783,"lomefloxacin, norfloxacin, sparfloxacin, nadifloxacin",0.242603971206976,0.106238237942057,FALSE
+"H1703","Pearson.est","BCL inhibitor",0.32225,0.888,0.588,23,0.972,"navitoclax",0.230622673923862,0.0123337350737254,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.28265,0.756,0.72,137,0.944,"dasatinib, bosutinib",0.142667503568732,0.025028005701931,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",-0.30909,-0.738,0.786,1039,0.957,"temazepam, nefiracetam, lorazepam, bentazepam, indiplon",0.104577453960592,0.0190880622231565,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",-0.57067,-1.38,0.101,971,0.551,"I.BET151, JQ1...., OTX015, bromosporine",0.995678626217357,0.258848401148215,FALSE
+"H1703","Pearson.est","calcium channel blocker",-0.48247,-1.17,0.261,1112,0.596,"mibefradil, pranidipine, carboxyamidotriazole",0.583359492661719,0.224753740259764,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.40593,-0.981,0.49,983,0.715,"PF.04136309, UNBS.5162, MK.0812, SB.225002",0.309803919971486,0.145693958198919,FALSE
+"H1703","Pearson.est","CDK inhibitor",-0.3806,-0.909,0.575,707,0.789,"BMS.265246, JNJ.7706621, kenpaullone, indisulam, arcyriaflavin.a, AT.7519, palbociclib, NU6027, PHA.848125, BMS.387032, dinaciclib, PHA.793887, abemaciclib, R547",0.24033215531037,0.10292299679058,FALSE
+"H1703","Pearson.est","CHK inhibitor",0.46095,1.27,0.194,316,0.692,"LY2603618, CHIR.124, SCH.900776, LY2606368, AZD7762",0.712198270069774,0.159893905543242,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",0.21178,0.574,0.943,128,1,"aspirin, ramifenazone, phenazone, FK.3311",0.0254883072626717,0,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",-0.42948,-1.04,0.437,745,0.645,"eplerenone, PF.4981517, clotrimazole, metyrapone, cobicistat",0.359518563029578,0.190440285364732,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.54256,-1.32,0.148,1158,0.544,"mitomycin.c, temozolomide, TH.302, dianhydrogalactitol, carmustine, melphalan, carboplatin, cisplatin",0.829738284605043,0.26440110030182,FALSE
+"H1703","Pearson.est","DNA inhibitor",-0.52598,-1.27,0.192,1054,0.535,"teroxirone, tirapazamine, oxaliplatin, sangivamycin, pibenzimol, carmustine, melphalan, carboplatin, valrubicin, chlorambucil",0.71669877129645,0.271646217978772,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",-0.36463,-0.873,0.62,1209,0.812,"RG108, disulfiram",0.207608310501746,0.0904439707588247,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",-0.51414,-1.24,0.21,888,0.545,"idoxuridine, trifluridine, foscarnet, menadione",0.677780705266081,0.263603497723358,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.48735,-1.15,0.306,841,0.571,"nelarabine, anisomycin, artesunate, enocitabine, estramustine.phosphate, CB.10.277, azodicarbonamide, mitomycin.c, artemisinin, altretamine, cyclocytidine, cisplatin",0.51427857351842,0.243363891754152,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",-0.4681,-1.15,0.283,939,0.571,"UH.232...., thioproperazine, sertindole, amisulpride, isofloxythepin, paliperidone, nemonapride, raclopride",0.54821356447571,0.243363891754152,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",0.33472,0.884,0.602,966,0.926,"ethinyl.estradiol, PPT, equol, levonorgestrel, estradiol, erteberel, estrone, estradiol.cypionate",0.220403508742175,0.0333890133180656,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",0.25024,0.666,0.849,151,0.996,"clomifene, raloxifene",0.0710923097560473,0.00174066157630127,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.56275,-1.34,0.126,1230,0.527,"orantinib, dovitinib, nintedanib, erdafitinib",0.899629454882437,0.278189384787453,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",-0.32943,-0.799,0.734,1239,0.91,"dovitinib, TG.101348, GTP.14564",0.134303940083929,0.0409586076789064,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",-0.28479,-0.681,0.862,793,0.986,"halobetasol.propionate, clobetasol.propionate, beclomethasone.dipropionate, desonide, prednisolone.hemisuccinate, rimexolone, deflazacort, piretanide, flumethasone.pivalate, triamcinolone, fluticasone.propionate, dexamethasone.acetate, halcinonide",0.0644927341752872,0.0061230850587888,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.19528,0.55,0.974,292,1,"diazooxonorleucine, latrepirdine, IEM1754, SIB.1757, tiletamine",0.0114410431213845,0,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.37111,1.02,0.413,28,0.847,"LY2090314",0.384049948343599,0.0721165896692931,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",0.18979,0.531,0.972,272,1,"GSK1838705A, AZD3463, GSK1904529A",0.0123337350737254,0,FALSE
+"H1703","Pearson.est","HCV inhibitor",-0.48989,-1.16,0.302,1200,0.595,"Ro.9187, mericitabine",0.519993057042849,0.22548303427145,FALSE
+"H1703","Pearson.est","HDAC inhibitor",-0.2421,-0.593,0.939,717,1,"SB.939, belinostat, givinostat, romidepsin, scriptaid, pyroxamide, resminostat, chidamide, dacinostat, R306465, NSC.3852, entinostat, AR.42, nexturastat.a, ACY.1215, RGFP966",0.0273344077338891,0,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.27575,0.763,0.719,203,0.974,"ranitidine, zolantidine, terfenadine, levocetirizine, ebastine, famotidine",0.143271109617117,0.0114410431213845,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.82678,-1.98,0,1258,0.0339,"fluvastatin, pitavastatin, mevastatin, atorvastatin",Inf,1.46980030179692,TRUE
+"H1703","Pearson.est","HSP inhibitor",-0.32247,-0.772,0.746,1445,0.93,"NMS.E973",0.127261172527331,0.0315170514460649,FALSE
+"H1703","Pearson.est","JAK inhibitor",0.18176,0.494,0.993,106,0.983,"atiprimod, CEP.33779",0.00305075150461883,0.00744648216786438,FALSE
+"H1703","Pearson.est","KIT inhibitor",-0.2165,-0.52,0.977,812,0.988,"sorafenib, lenvatinib, regorafenib, KI.8751, motesanib, cediranib, pazopanib",0.0101054362812269,0.00524305541237188,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.46936,-1.13,0.314,1157,0.535,"idasanutlin, nutlin.3, AMG.232",0.503070351926785,0.271646217978772,FALSE
+"H1703","Pearson.est","MEK inhibitor",0.75632,2.06,0.00345,172,0.0797,"trametinib, AS.703026, Ro.4987655, AZD8330, PD.0325901, cobimetinib, TAK.733, selumetinib, refametinib, PD.184352, MEK162, PD.318088",2.46218090492673,1.09854167860389,TRUE
+"H1703","Pearson.est","MET inhibitor",0.36875,1.05,0.406,64,0.837,"INC.280",0.391473966422806,0.07727454200674,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.47108,-1.13,0.298,890,0.535,"cytochalasin.b, estramustine.phosphate, D.64131, secnidazole, triclabendazole, vinflunine, vinblastine",0.525783735923745,0.271646217978772,FALSE
+"H1703","Pearson.est","mTOR inhibitor",-0.22373,-0.549,0.965,897,0.993,"WAY.600, PP242, PF.04691502, PI.103, torin.1, deforolimus, XL388, OSI.027, ku.0063794",0.0154726866562074,0.00305075150461883,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.62203,-1.49,0.0834,1048,0.55,"bindarit, IKK.2.inhibitor.V, parthenolide, betulinic.acid, EVP4593, tyloxapol, BAY.11.7082",1.07883394936226,0.259637310505756,FALSE
+"H1703","Pearson.est","opioid receptor agonist",0.33079,0.889,0.545,971,1,"ADL5859, salvinorin.a, BW.180C, spiradoline, trimebutine, cebranopadol",0.263603497723358,0,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.3449,0.928,0.541,951,1,"TAK.715, SB.239063, SB.242235, CMPD.1, talmapimod, VX.702, skepinone.l",0.266802734893431,0,FALSE
+"H1703","Pearson.est","PARP inhibitor",-0.46748,-1.13,0.316,706,0.535,"niraparib, olaparib, E7449, talazoparib, endo.IWR.1, AG.14361, AZD2461",0.500312917381596,0.271646217978772,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.36549,-0.874,0.638,812,0.83,"sorafenib, lenvatinib, regorafenib, linifanib, KI.8751, axitinib, CP.673451, motesanib, orantinib, dovitinib, SU014813, nintedanib, pazopanib",0.195179321278838,0.0809219076239261,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.64821,-1.56,0.0406,1384,0.429,"menadione, bis.maltolato.oxovanadium.IV., GSK2830371",1.39147396642281,0.367542707815276,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",-0.24739,-0.588,0.937,1399,0.989,"GSK256066",0.0282604091122217,0.0048037084028206,FALSE
+"H1703","Pearson.est","PI3K inhibitor",-0.20314,-0.481,0.98,925,0.984,"PF.04691502, PI.103, CUDC.907, YM.201636, idelalisib, BGT226, buparlisib, ZSTK.474, AZD6482",0.00877392430750515,0.00700490156865849,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.56264,-1.35,0.13,1107,0.543,"GSK461364, rigosertib, volasertib, GW.843682X",0.886056647693163,0.265200170411153,FALSE
+"H1703","Pearson.est","potassium channel blocker",-0.45254,-1.07,0.388,777,0.61,"meglitinide, ML133, ibutilide, dofetilide, mepivacaine",0.411168274405793,0.214670164989233,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",-0.66131,-1.59,0.0315,1330,0.582,"GW.501516, clofibrate",1.5016894462104,0.235077015350112,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.42051,-1,0.455,1324,0.7,"tanaproget, norethindrone",0.341988603342888,0.154901959985743,FALSE
+"H1703","Pearson.est","proteasome inhibitor",-0.52828,-1.26,0.192,1429,0.528,"MG.132",0.71669877129645,0.277366077466188,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.47875,-1.18,0.281,1160,0.6,"homoharringtonine, methacycline, bruceantin, thiostrepton, anguidine, mercaptopurine, harringtonine",0.55129368009492,0.221848749616356,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.662,1.76,0.0169,49,0.225,"BMS.599626, AV.412, CP.724714",1.77211329538633,0.647817481888638,TRUE
+"H1703","Pearson.est","RAF inhibitor",-0.39021,-0.927,0.565,759,0.797,"dabrafenib, sorafenib, regorafenib, LGX818, SB.590885, PLX.4720, RAF265, TAK.632",0.247951552180562,0.0985416786038876,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.47445,1.33,0.157,19,0.65,"vandetanib",0.804100347590766,0.187086643357144,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",-0.5624,-1.38,0.114,1229,0.551,"bexarotene, LE.135, adapalene, fenretinide",0.943095148663527,0.258848401148215,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.66801,-1.59,0.0323,1026,0.582,"LY2334737, gemcitabine, hydroxyurea, fludarabine.phosphate, clofarabine, fludarabine, triapine, pentostatin, cladribine",1.4907974776689,0.235077015350112,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",-0.57141,-1.38,0.115,1447,0.551,"aripiprazole",0.939302159646388,0.258848401148215,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",-0.63751,-1.57,0.0274,1260,0.503,"paliperidone, pirenperone, lerisetron, aripiprazole",1.56224943717961,0.298432014944073,FALSE
+"H1703","Pearson.est","sodium channel blocker",-0.47412,-1.13,0.324,1194,0.535,"quinidine, mepivacaine, butamben, cibenzoline",0.489454989793388,0.271646217978772,FALSE
+"H1703","Pearson.est","src inhibitor",0.60815,1.62,0.0601,137,0.263,"saracatinib, ZM.306416, dasatinib, bosutinib",1.22112552799726,0.580044251510242,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.56512,-1.36,0.119,1307,0.558,"chlormidazole, posaconazole",0.924453038607469,0.253365801062421,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.30253,0.861,0.592,295,0.876,"repsox, SB.431542, LY2109761, D.4476",0.22767829327708,0.0574958938319193,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",0.31623,0.869,0.573,992,0.907,"capecitabine, carmofur, raltitrexed, doxifluridine, ftorafur, trifluridine",0.24184537803261,0.0423927129399047,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.58964,-1.44,0.0773,1079,0.552,"idarubicin, SN.38, amsacrine, mitoxantrone, nemorubicin, daunorubicin, topotecan, dexrazoxane, etoposide, TAS.103, voreloxin, etoposide.phosphate, teniposide, doxorubicin, valrubicin, epirubicin",1.11182050608168,0.258060922270801,FALSE
+"H1703","Pearson.est","tubulin polymerization inhibitor",-0.53891,-1.29,0.183,1137,0.548,"epothilone.d, flubendazole, combretastatin.A.4, ABT.751, KX2.391, vinorelbine, vincristine, vindesine, BNC105, verubulin, vinblastine, taltobulin",0.737548910269571,0.261219441515631,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.43488,1.18,0.275,49,0.739,"BMS.599626, vandetanib, AV.412, dasatinib, CP.724714",0.560667306169737,0.131355561605174,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",0.29093,0.784,0.688,77,0.978,"BMS.690514, XL.647, vandetanib, ZM.306416, golvatinib",0.162411561764489,0.00966114521239857,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.76649,2.03,0.0076,270,0.0686,"maxacalcitol, paricalcitol, ercalcitriol, tacalcitol, calcitriol",2.11918640771921,1.16367588429325,TRUE
+"H460","Pearson.est","EGFR inhibitor",-0.28934,-0.706,0.848,908,0.877,"OSI.420, dovitinib, CGP.52411, CP.724714, osimertinib, TAK.285, WZ.3146, pelitinib, ARRY.334543, neratinib, brigatinib, afatinib, tyrphostin.AG.1478, vandetanib, erlotinib, rociletinib, salvianolic.acid.B",0.0716041477432862,0.0570004066339595,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.61097,-1.5,0.0623,1163,0.382,"tozasertib, flumatinib, KW.2449, bosutinib, metatinib, GZD824",1.20551195334083,0.417936637088291,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.48976,-1.2,0.265,1412,0.505,"xanomeline",0.576754126063192,0.296708621881339,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.58377,1.65,0.0541,111,0.237,"hyoscyamine, dicycloverine",1.26680273489343,0.625251653989896,FALSE
+"H460","Pearson.est","adenosine receptor antagonist",0.46695,1.3,0.171,267,0.427,"theophylline, CGS.15943, MRS.1220",0.767003889607846,0.369572124974976,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",-0.29593,-0.735,0.779,1368,0.876,"buphenine, clenbuterol",0.108462542327436,0.0574958938319193,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",0.24559,0.716,0.832,159,0.905,"prazosin, atenolol...., atenolol......, RS.17053, dihydroergocristine",0.0798766737092761,0.0433514207947967,FALSE
+"H460","Pearson.est","AKT inhibitor",0.30594,0.873,0.622,273,0.862,"GSK2110183, AZD5363, AT7867, CCT128930, MK.2206",0.206209615309181,0.0644927341752872,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41935,-1.04,0.408,868,0.694,"AZD3463, AP26113, alectinib, brigatinib, GW.788388, lorlatinib, crizotinib",0.38933983691012,0.158640529545145,FALSE
+"H460","Pearson.est","androgen receptor antagonist",0.5527,1.58,0.0508,651,0.202,"RU.58841, bicalutamide, enzalutamide, cyproterone.acetate, flutamide, nilutamide",1.29413628771608,0.694648630553376,FALSE
+"H460","Pearson.est","antioxidant",-0.5591,-1.37,0.13,933,0.378,"mesna, benfotiamine, chlorogenic.acid, rutin, taurine",0.886056647693163,0.422508200162775,FALSE
+"H460","Pearson.est","AP inhibitor",0.23648,0.679,0.849,1107,0.882,"LCL.161, GDC.0152, birinapant, tanshinone.i, embelin, idronoxil",0.0710923097560473,0.0545314148681803,FALSE
+"H460","Pearson.est","ATPase inhibitor",-0.51948,-1.28,0.169,1181,0.436,"rabeprazole, digitoxin, digoxin, thonzonium, digitoxigenin, k.strophanthidin",0.772113295386326,0.360513510731414,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.55904,-1.38,0.12,972,0.382,"PF.03814735, CYC116, AT.9283, AMG900, TAK.901, PHA.680632, GSK1070916, ENMD.2076, tozasertib, barasertib, KW.2449, alisertib, MK.5108, danusertib, MLN.8054, MK.8745, hesperadin",0.920818753952375,0.417936637088291,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.33301,-0.821,0.689,799,0.846,"azithromycin, radezolid, valnemulin, azalomycin.b, tedizolid",0.161780778092374,0.0726296369609765,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.29638,0.821,0.694,287,0.842,"nadifloxacin, norfloxacin, trovafloxacin, sparfloxacin, sarafloxacin",0.158640529545145,0.0746879085003505,FALSE
+"H460","Pearson.est","BCL inhibitor",0.35363,1.02,0.391,5,0.695,"ABT.737",0.407823242604133,0.158015195409886,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.59297,-1.46,0.0788,1163,0.33,"tozasertib, flumatinib, bosutinib, metatinib, GZD824",1.10347378251044,0.481486060122112,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",-0.25024,-0.613,0.917,1150,0.913,"ZK.93423, ivermectin, bentazepam",0.0376306643299789,0.039529222465701,FALSE
+"H460","Pearson.est","bromodomain inhibitor",0.62603,1.79,0.0302,149,0.423,"I.BET151",1.51999305704285,0.373659632624958,FALSE
+"H460","Pearson.est","calcium channel blocker",0.41089,1.12,0.29,240,0.696,"mibefradil, pranidipine, fendiline, efonidipine.monoethanolate",0.537602002101044,0.157390760389438,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.33402,-0.816,0.709,1132,0.834,"navarixin, UNBS.5162",0.149353764816933,0.0788339493622613,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.34273,-0.84,0.657,1046,0.874,"alvocidib, indisulam, palbociclib, R547, PHA.793887, ribociclib, aminopurvalanol.a, JNJ.7706621, PHA.848125",0.182434630440219,0.058488567365597,FALSE
+"H460","Pearson.est","CHK inhibitor",-0.42276,-1.05,0.402,659,0.695,"AZD7762, CHIR.124, SB.218078, PF.477736, SCH.900776, LY2606368",0.39577394691553,0.158015195409886,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.24999,-0.619,0.912,1215,0.942,"suxibuzone, FK.3311, ketoprofen, AM.404",0.0400051616715838,0.0259490972071227,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",0.59268,1.77,0.0377,307,0.226,"itraconazole, eplerenone, metyrapone, morin, cobicistat",1.42365864979421,0.645891560852599,TRUE
+"H460","Pearson.est","DNA alkylating agent",-0.4506,-1.1,0.328,1122,0.638,"cisplatin, dianhydrogalactitol, mitomycin.c, satraplatin, dacarbazine",0.484126156288321,0.195179321278838,FALSE
+"H460","Pearson.est","DNA inhibitor",0.16308,0.468,0.988,130,0.991,"pibenzimol, metronidazole",0.00524305541237188,0.00392634551472468,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.31047,-0.757,0.753,1058,0.883,"decitabine, fdcyd, disulfiram",0.123205023799299,0.0540392964224314,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",-0.25361,-0.616,0.91,1310,0.927,"cephalomannine",0.0409586076789064,0.0329202658555029,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.51639,-1.29,0.18,1004,0.438,"artemisinin, CB.10.277, enocitabine, cisplatin, cyclocytidine, mitomycin.c, anisomycin, floxuridine",0.744727494896694,0.3585258894959,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",0.62825,1.77,0.0121,211,0.226,"paliperidone, remoxipride, acetophenazine, domperidone, lurasidone, isofloxythepin, clebopride, raclopride, mesoridazine, nemonapride",1.91721462968355,0.645891560852599,TRUE
+"H460","Pearson.est","estrogen receptor agonist",0.30944,0.855,0.603,206,0.856,"equol, erteberel",0.219682687859849,0.0675262353228468,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",0.54142,1.54,0.0431,123,0.212,"tamoxifen, clomifene",1.36552272983927,0.673664139071249,TRUE
+"H460","Pearson.est","FGFR inhibitor",-0.37248,-0.912,0.55,699,0.831,"erdafitinib, lenvatinib, lucitanib, AZD4547, dovitinib, MK.2461, PD.173074, regorafenib",0.259637310505756,0.080398976215889,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.38983,-0.953,0.521,1093,0.799,"midostaurin, gilteritinib, ENMD.2076, quizartinib, tozasertib, KW.2449, lestaurtinib",0.283162276700476,0.0974532206860086,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",0.5849,1.62,0.0598,229,0.226,"hydrocortisone, piretanide, prednisolone.hemisuccinate, deflazacort, triamcinolone, triamcinolone.acetonide, dexamethasone.acetate, halcinonide, methylprednisolone",1.22329881601159,0.645891560852599,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.25087,0.687,0.815,1088,0.907,"MTPG, CPP, CGP.37849, IEM1754, kynurenic.acid, latrepirdine, JNJ.16259685, SIB.1757, diazooxonorleucine, LY456236, ACDPP, tiletamine, felbamate",0.0888423912600234,0.0423927129399047,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",0.37568,1.05,0.389,34,0.728,"CHIR.98014",0.410050398674292,0.137868620686963,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.61776,-1.52,0.0592,1358,0.439,"danusertib, PHA.848125, lestaurtinib",1.22767829327708,0.357535479757879,FALSE
+"H460","Pearson.est","HCV inhibitor",0.36893,1.02,0.386,916,0.695,"Ro.9187, daclatasvir, PSI.7976, embelin, narlaprevir, mericitabine",0.413412695328245,0.158015195409886,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.60371,-1.49,0.066,1095,0.304,"NSC.3852, entinostat, SB.939, givinostat, dacinostat, AR.42, PCI.24781, JNJ.26481585, M.344, vorinostat, tacedinaline, belinostat, resminostat, trichostatin.a, panobinostat, chidamide",1.18045606445813,0.517126416391246,FALSE
+"H460","Pearson.est","histamine receptor antagonist",0.25468,0.733,0.778,1,0.918,"chloropyramine",0.109020403010311,0.0371573187987575,FALSE
+"H460","Pearson.est","HMGCR inhibitor",-0.71271,-1.75,0.00535,1204,0.205,"mevastatin, atorvastatin, pitavastatin, fluvastatin",2.27164621797877,0.688246138944246,TRUE
+"H460","Pearson.est","HSP inhibitor",-0.61184,-1.49,0.0671,1044,0.304,"ganetespib, NVP.AUY922, KW.2478, SNX.5422, BIIB021, VER.49009, SNX.2112, PU.H71, NMS.E973",1.17327747983101,0.517126416391246,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.49242,-1.21,0.253,1116,0.505,"LY2784544, tozasertib, TG.101209, ruxolitinib, CEP.33779, AZ960, lestaurtinib, WHI.P154",0.596879478824182,0.296708621881339,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.36153,-0.88,0.61,932,0.869,"dasatinib, sorafenib, OSI.930, midostaurin, pazopanib, masitinib, regorafenib, KI.8751",0.214670164989233,0.0609802235513335,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.28585,-0.706,0.829,1337,0.877,"serdemetan",0.0814454694497265,0.0570004066339595,FALSE
+"H460","Pearson.est","MEK inhibitor",0.25845,0.759,0.761,354,0.913,"cobimetinib, PD.318088, selumetinib, AS.703026, BIX.02188, trametinib, PD.0325901, U.0126, AZD8330",0.118615343229427,0.039529222465701,FALSE
+"H460","Pearson.est","MET inhibitor",-0.44703,-1.09,0.368,883,0.636,"AMG458, INC.280, LY2801653",0.434152181326482,0.196542884351586,FALSE
+"H460","Pearson.est","microtubule inhibitor",-0.63341,-1.56,0.044,1341,0.403,"vinflunine, D.64131, vinblastine, cabazitaxel",1.35654732351381,0.39469495385889,FALSE
+"H460","Pearson.est","mTOR inhibitor",-0.57367,-1.4,0.126,949,0.39,"PF.05212384, WYE.125132, torin.2, PF.04691502, GSK2126458, torin.1, LY3023414, everolimus, PI.103, MLN0128, AZD8055, NVP.BEZ235, voxtalisib, PP242, temsirolimus, WAY.600, AZD2014, PKI.179, deforolimus, sirolimus",0.899629454882437,0.408935392973501,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",0.39266,1.1,0.307,239,0.681,"tyloxapol, betulinic.acid, curcumin, parthenolide....",0.512861624522813,0.166852888087215,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.33272,-0.831,0.681,1010,0.848,"trimebutine, spiradoline, salvinorin.a",0.166852888087215,0.0716041477432862,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",-0.34903,-0.865,0.626,774,0.852,"TAK.715, VX.702, SB.239063, talmapimod, SB.242235, CMPD.1",0.20342566678957,0.0695604052332999,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.56807,-1.38,0.117,1145,0.382,"niraparib, AG.14361, olaparib, talazoparib",0.931814138253838,0.417936637088291,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.3031,-0.746,0.777,1208,0.88,"crenolanib, pazopanib, masitinib, regorafenib, KI.8751",0.109578981199086,0.0555173278498314,FALSE
+"H460","Pearson.est","phosphatase inhibitor",-0.39621,-0.973,0.517,1264,0.783,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV.",0.286509456906058,0.106238237942057,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",-0.59326,-1.49,0.0679,969,0.304,"trequinsin, YM.976, anagrelide, EMD.53998, GSK256066, zardaverine, papaverine",1.1681302257195,0.517126416391246,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.33872,-0.831,0.668,861,0.848,"PI.828, GDC.0980, LY303511, CH5132799, alpelisib, PF.05212384, PF.04691502, GSK2126458, TG.100713, LY3023414, GDC.0941, PI.103, NVP.BEZ235, voxtalisib, PKI.179, CUDC.907",0.175223537524454,0.0716041477432862,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.88802,-2.17,0,1425,0.00175,"BI.2536, rigosertib, volasertib, HMN.214, NMS.1286937",Inf,2.75696195131371,TRUE
+"H460","Pearson.est","potassium channel blocker",-0.35791,-0.869,0.622,903,0.866,"ibutilide, meglitinide, oleoylethanolamide",0.206209615309181,0.0624821079826534,FALSE
+"H460","Pearson.est","PPAR receptor agonist",0.56622,1.59,0.0735,113,0.22,"fenofibrate, GW.501516, S26948",1.1337126609158,0.657577319177794,FALSE
+"H460","Pearson.est","progesterone receptor agonist",0.35094,0.988,0.446,943,0.716,"melengestrol.acetate, norethindrone.acetate, danazol, levonorgestrel, dienogest, norgestrel, norethindrone, tanaproget, nomegestrol.acetate",0.350665141287858,0.145086977692144,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.33056,0.925,0.537,972,0.799,"oprozomib, carfilzomib, MG.132, ONX.0914, ixazomib.citrate, ixazomib, bortezomib, delanzomib",0.270025714300444,0.0974532206860086,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.72718,-1.79,0.0116,1210,0.218,"tedizolid.phosphate, mercaptopurine, bruceantin, harringtonine, puromycin, thiostrepton, emetine, anguidine, homoharringtonine, cycloheximide",1.93554201077308,0.661543506395395,TRUE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.54713,-1.31,0.142,963,0.466,"CP.724714, mubritinib, AV.412, PP.121, NVP.TAE226, tyrphostin.A9",0.847711655616944,0.33161408331,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.38598,-0.938,0.561,921,0.805,"CEP.32496, sorafenib, LGX818, regorafenib, RAF265",0.251037138743839,0.0942041196321315,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.60142,-1.5,0.0597,964,0.382,"sorafenib, apatinib, cabozantinib, vandetanib, regorafenib",1.22402566887063,0.417936637088291,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.47069,-1.16,0.3,1162,0.542,"adapalene, adarotene",0.522878745280338,0.266000713461613,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.48552,-1.21,0.223,886,0.505,"hydroxyurea, fludarabine, gemcitabine, clofarabine, triapine, fludarabine.phosphate",0.651695136951839,0.296708621881339,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.53627,-1.29,0.167,1447,0.438,"aripiprazole",0.777283528852417,0.3585258894959,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.50929,-1.25,0.203,1276,0.47,"SB.228357, SB.200646, SB.216641, aripiprazole",0.692503962086787,0.327902142064283,FALSE
+"H460","Pearson.est","sodium channel blocker",0.29858,0.835,0.649,173,0.853,"benzethonium, lappaconite, mepivacaine",0.187755303199631,0.069050968832477,FALSE
+"H460","Pearson.est","src inhibitor",-0.57958,-1.42,0.0892,932,0.378,"dasatinib, saracatinib, KX2.391, masitinib, bosutinib, TG.100572",1.04963514562388,0.422508200162775,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.4141,-1.01,0.443,1169,0.733,"ketoconazole, chlormidazole, lanoconazole",0.35359627377693,0.134896025358872,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",0.59553,1.66,0.041,393,0.274,"adaprev, repsox, SB.431542, LY2109761, SB.525334",1.38721614328026,0.562249437179612,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.48419,-1.19,0.255,939,0.506,"raltitrexed, trifluridine, carmofur",0.593459819566045,0.295849483160201,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.6876,-1.67,0.0215,1097,0.232,"nemorubicin, exatecan.mesylate, valrubicin, etoposide.phosphate, doxorubicin, idarubicin, etoposide, voreloxin, rubitecan, camptothecin, genz.644282, teniposide, daunorubicin, dexrazoxane, irinotecan, SN.38, amonafide, amsacrine, TAS.103, topotecan, mitoxantrone",1.66756154008439,0.6345120151091,TRUE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.69769,-1.69,0.0144,1168,0.253,"CYT.997, vincristine, combretastatin.A.4, dolastatin.10, taltobulin, fenbendazole, indibulin, plinabulin, vinorelbine, epothilone.b, epothilone.d, docetaxel, verubulin, paclitaxel, vindesine, ABT.751, vinblastine, parbendazole, BNC105, fosbretabulin, mebendazole",1.84163750790475,0.596879478824182,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.52616,-1.29,0.174,932,0.438,"dasatinib, CP.724714, sorafenib, mubritinib, apatinib, AMG.208, AV.412, UNC2250, cabozantinib, PP.121, vandetanib, NVP.TAE226, regorafenib, aminopurvalanol.a, tyrphostin.A9, tivantinib",0.7594507517174,0.3585258894959,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.32047,-0.782,0.732,877,0.866,"axitinib, dovitinib, SAR131675, MK.2461, sorafenib, foretinib, OSI.930, tivozanib, PD.173074, cabozantinib, ENMD.2076, pazopanib, vandetanib, regorafenib, KI.8751, TG.100572, RAF265",0.135488918941608,0.0624821079826534,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",0.73212,2.08,0.0119,157,0.206,"paricalcitol, alfacalcidol, tacalcitol, doxercalciferol, maxacalcitol",1.92445303860747,0.686132779630847,TRUE
+"H520","Pearson.est","EGFR inhibitor",-0.3734,-0.906,0.572,840,0.735,"XL.647, GW.583340, brigatinib, dacomitinib, gefitinib, CGP.52411, lapatinib, poziotinib, AZD8931, afatinib, tyrphostin.AG.1478, WZ.4002, BMS.599626, AEE788, CP.724714, rociletinib, CNX.2006, ARRY.334543, tucatinib, WZ.3146, BIBX.1382, TAK.285, neratinib, dovitinib, CUDC.101",0.242603971206976,0.133712660915805,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",-0.33234,-0.799,0.705,727,0.805,"bafetinib, flumatinib, nilotinib, ponatinib, KW.2449, bosutinib, tozasertib, metatinib, imatinib, GZD824",0.151810883008601,0.0942041196321315,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",0.32596,0.881,0.558,122,0.798,"nefiracetam, nicotine",0.253365801062421,0.0979971086492706,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",0.85162,2.25,0,85,0.0244,"dicycloverine, hyoscyamine, iododexetimide",Inf,1.61261017366127,TRUE
+"H520","Pearson.est","adenosine receptor antagonist",-0.34437,-0.835,0.665,910,0.789,"sulmazole, SCH.58261, MRS.1220, CGS.15943",0.177178354696895,0.10292299679058,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.33357,0.923,0.559,970,0.829,"midodrine, isoetharine, isoxsuprine, norepinephrine, terbutaline, ritodrine, xylazine, buphenine, epinephrine, oxymetazoline, A61603, clenbuterol, metaraminol, methyldopa, lidamidine",0.252588192113577,0.0814454694497265,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",0.19685,0.556,0.959,276,1,"atenolol...., imiloxan, metoprolol, levobunolol, RS.17053",0.0181813928293364,0,FALSE
+"H520","Pearson.est","AKT inhibitor",-0.4742,-1.13,0.322,1249,0.452,"ONC201, A.674563, GDC.0068, uprosertib",0.492144128304169,0.344861565188618,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31646,-0.757,0.756,968,0.828,"NVP.TAE684, CEP.37440, alectinib, crizotinib, AZD3463",0.121478204498793,0.0819696632151199,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.77514,2.13,0,236,0.0334,"bicalutamide, RU.58841, cyproterone.acetate",Inf,1.47625353318844,TRUE
+"H520","Pearson.est","antioxidant",0.40014,1.05,0.347,871,0.732,"benfotiamine, trolox, taurine, chlorogenic.acid, mesna, rutin",0.459670525209126,0.135488918941608,FALSE
+"H520","Pearson.est","AP inhibitor",0.3158,0.9,0.543,156,0.835,"LCL.161, GDC.0152",0.265200170411153,0.0783135245163979,FALSE
+"H520","Pearson.est","ATPase inhibitor",-0.60996,-1.44,0.0715,1153,0.337,"digitoxigenin, oligomycin.a, evodiamine, rabeprazole, NMS.873, digoxin, k.strophanthidin",1.14569395819892,0.472370099128661,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.64433,-1.58,0.0504,967,0.308,"CCT129202, PF.03814735, MK.5108, tozasertib, aurora.a.inhibitor.i, hesperadin, AT.9283, MK.8745, GSK1070916, CYC116, SNS.314, alisertib, AMG900, barasertib.HQPA, CCT137690, ENMD.2076, barasertib, TAK.901, danusertib, PHA.680632",1.29756946355447,0.511449283499556,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45588,-1.09,0.357,1047,0.494,"azalomycin.b, radezolid, valnemulin, tedizolid",0.447331783887807,0.306273051076353,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.43329,1.2,0.221,398,0.586,"sparfloxacin, sarafloxacin, norfloxacin, novobiocin, trovafloxacin, nadifloxacin",0.655607726314889,0.232102383981909,FALSE
+"H520","Pearson.est","BCL inhibitor",0.28681,0.774,0.741,1035,0.892,"ABT.737, obatoclax, venetoclax, HA14.1, navitoclax, oridonin, gossypol, TW.37",0.130181792020672,0.0496351456238769,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.33735,-0.807,0.711,727,0.812,"bafetinib, flumatinib, nilotinib, ponatinib, bosutinib, tozasertib, metatinib, imatinib, GZD824",0.148130399270234,0.0904439707588247,FALSE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.3781,1.05,0.35,157,0.732,"lorazepam, nefiracetam, gamma.aminobutyric.acid, indiplon",0.455931955649724,0.135488918941608,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.73355,-1.76,0.0188,1309,0.152,"JQ1...., I.BET.762, I.BET151, OTX015",1.72584215073632,0.818156412055227,TRUE
+"H520","Pearson.est","calcium channel blocker",-0.36026,-0.881,0.626,1128,0.756,"carboxyamidotriazole, tetrandrine, penfluridol",0.20342566678957,0.121478204498793,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",-0.60963,-1.46,0.0862,1108,0.327,"RS.504393, ZK811752, SB.225002, UNBS.5162",1.06449273417529,0.485452247339714,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.54595,-1.3,0.18,1169,0.385,"JNJ.7706621, BMS.265246, dinaciclib, TG.02, AT.7519, PHA.793887, arcyriaflavin.a, ribociclib, aminopurvalanol.a, BMS.387032, indisulam",0.744727494896694,0.414539270491499,FALSE
+"H520","Pearson.est","CHK inhibitor",0.3817,1.03,0.414,290,0.73,"LY2606368, AZD7762, SCH.900776, LY2603618",0.382999658879101,0.136677139879544,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",-0.15721,-0.375,1,810,0.999,"curcumin, FK.3311, ramifenazone, FR.122047, ketoprofen, meloxicam, tepoxalin, suxibuzone, amfenac, piroxicam, AM.404",0,0.000434511774017692,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.80005,2.22,0,247,0.0244,"eplerenone, morin, metyrapone, clotrimazole, itraconazole, cobicistat",Inf,1.61261017366127,TRUE
+"H520","Pearson.est","DNA alkylating agent",-0.47069,-1.16,0.304,1120,0.447,"cyclophosphamide, estramustine, dacarbazine, satraplatin, mitomycin.c",0.517126416391246,0.349692476868064,FALSE
+"H520","Pearson.est","DNA inhibitor",0.15828,0.428,0.986,978,0.996,"carboplatin, nithiamide, sangivamycin, metronidazole, nimorazole, carmustine, tirapazamine, melphalan, busulfan, bendamustine, pibenzimol, chlorambucil, mechlorethamine, primaquine, teroxirone, oxaliplatin",0.0061230850587888,0.00174066157630127,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.54092,-1.3,0.168,1092,0.385,"azacitidine, SGI.1027, disulfiram, decitabine, fdcyd",0.774690718274137,0.414539270491499,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",-0.49607,-1.22,0.247,927,0.446,"famciclovir, cidofovir, adefovir.dipivoxil, idoxuridine, trifluridine, cephalomannine",0.607303046740334,0.350665141287858,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.3802,-0.937,0.54,1230,0.702,"floxuridine, enocitabine, anisomycin, mitomycin.c",0.267606240177031,0.153662887870195,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",0.51328,1.42,0.108,309,0.421,"acetophenazine, isofloxythepin, paliperidone, ziprasidone, UH.232...., raclopride, remoxipride, clebopride",0.96657624451305,0.375717904164332,FALSE
+"H520","Pearson.est","estrogen receptor agonist",0.35694,1.01,0.41,934,0.73,"equol, estrone, PPT, estradiol, estradiol.cypionate, levonorgestrel, erteberel, ethinyl.estradiol",0.387216143280265,0.136677139879544,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",0.25728,0.711,0.807,1077,0.961,"tamoxifen, clomifene, raloxifene, toremifene, danazol, fulvestrant",0.0931264652779296,0.0172766123314547,FALSE
+"H520","Pearson.est","FGFR inhibitor",-0.59586,-1.43,0.11,1027,0.331,"erdafitinib, PD.173074, nintedanib, dovitinib, lenvatinib, regorafenib",0.958607314841775,0.480172006224281,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.59935,-1.46,0.0793,1164,0.327,"tyrphostin.AG.1296, TG.02, lestaurtinib, pacritinib, dovitinib, TG.101348, ENMD.2076, sorafenib",1.1007268126824,0.485452247339714,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",0.60788,1.64,0.0712,373,0.293,"hydrocortisone, piretanide, dexamethasone.acetate, prednisolone.acetate, fluocinolone.acetonide, prednisolone.hemisuccinate, flumethasone.pivalate, triamcinolone, clobetasol.propionate, halobetasol.propionate, flumethasone, prednisolone, beclomethasone.dipropionate, desonide",1.14752000636314,0.533132379645891,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",0.38509,1.05,0.354,113,0.732,"JNJ.16259685, latrepirdine, kynurenic.acid",0.450996737974212,0.135488918941608,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.50278,1.4,0.136,228,0.369,"CHIR.98014, CHIR.99021, LY2090314, tideglusib",0.866461091629782,0.43297363384094,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.59028,-1.42,0.1,1283,0.325,"AZD3463, lestaurtinib, danusertib",1,0.488116639021126,FALSE
+"H520","Pearson.est","HCV inhibitor",-0.36561,-0.868,0.628,1275,0.759,"mericitabine, narlaprevir",0.202040356262804,0.11975822410452,FALSE
+"H520","Pearson.est","HDAC inhibitor",-0.63293,-1.52,0.0484,1198,0.281,"entinostat, scriptaid, NSC.3852, AR.42, R306465, resminostat, vorinostat, dacinostat, trichostatin.a, givinostat, chidamide, SB.939, PCI.24781, M.344",1.31515463835559,0.55129368009492,FALSE
+"H520","Pearson.est","histamine receptor antagonist",0.51537,1.41,0.126,357,0.392,"chloropyramine, cimetidine, famotidine, nizatidine, terfenadine, BF2.649, zolantidine, astemizole, lafutidine, ICI.162846",0.899629454882437,0.406713932979543,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.69819,1.97,0.0109,375,0.0796,"simvastatin, pitavastatin, atorvastatin, fluvastatin, mevastatin",1.96257350205938,1.09908693226233,TRUE
+"H520","Pearson.est","HSP inhibitor",-0.51165,-1.22,0.238,887,0.446,"XL888, NVP.AUY922, KW.2478, SNX.2112, VER.49009, BIIB021, PU.H71, NMS.E973",0.623423042943488,0.350665141287858,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.55235,-1.34,0.146,978,0.379,"ruxolitinib, tozasertib, LY2784544, WHI.P154, AT.9283, TG.101209, TG.02, baricitinib, lestaurtinib, pacritinib, TG.101348, AZ960",0.835647144215563,0.421360790031928,FALSE
+"H520","Pearson.est","KIT inhibitor",-0.57923,-1.4,0.114,1269,0.339,"imatinib, pazopanib, lenvatinib, OSI.930, regorafenib, sorafenib",0.943095148663527,0.469800301796918,FALSE
+"H520","Pearson.est","MDM inhibitor",0.30444,0.819,0.662,1009,0.882,"idasanutlin, nutlin.3, AMG.232, CGM097, RITA, serdemetan",0.1791420105603,0.0545314148681803,FALSE
+"H520","Pearson.est","MEK inhibitor",0.19404,0.519,0.968,268,1,"nobiletin, PD.184352, cobimetinib, MEK1.2.inhibitor",0.0141246426916063,0,FALSE
+"H520","Pearson.est","MET inhibitor",-0.47057,-1.13,0.316,1173,0.452,"AMG458, NVP.BVU972, INC.280",0.500312917381596,0.344861565188618,FALSE
+"H520","Pearson.est","microtubule inhibitor",-0.48566,-1.18,0.274,1094,0.433,"triclabendazole, vinblastine, cabazitaxel, D.64131, vinflunine",0.562249437179612,0.363512103646635,FALSE
+"H520","Pearson.est","mTOR inhibitor",-0.56926,-1.37,0.112,1095,0.368,"XL388, NVP.BEZ235, WAY.600, everolimus, voxtalisib, PI.103, WYE.125132, PF.05212384, AZD8055, PF.04691502, AZD2014, torin.2, PP242, deforolimus, sirolimus, GSK2126458, PKI.179",0.950781977329818,0.434152181326482,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",-0.32545,-0.791,0.725,999,0.799,"BAY.11.7082, Ro.106.9920, parthenolide...., EVP4593",0.139661993429006,0.0974532206860086,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.53234,1.45,0.116,99,0.428,"cebranopadol, BW.180C",0.935542010773082,0.368556230986828,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.5281,-1.26,0.21,833,0.415,"VX.702, SB.239063, SB.242235, TAK.715, talmapimod",0.677780705266081,0.381951903287907,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.67364,-1.62,0.0391,1303,0.282,"olaparib, PJ.34, talazoparib, niraparib",1.40782324260413,0.549750891680639,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.48347,-1.18,0.288,1189,0.433,"nintedanib, crenolanib, imatinib, pazopanib, axitinib, dovitinib, lenvatinib, regorafenib, sorafenib",0.540607512240769,0.363512103646635,FALSE
+"H520","Pearson.est","phosphatase inhibitor",-0.26084,-0.623,0.901,812,0.92,"CID.5458317, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., alexidine, mycophenolate.mofetil",0.045275209020937,0.0362121726544447,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",0.22462,0.605,0.916,1125,1,"YM.976, trequinsin, GSK256066, anagrelide, cilostamide, zardaverine, EMD.53998, enoximone, papaverine, avanafil",0.0381045263321496,0,FALSE
+"H520","Pearson.est","PI3K inhibitor",-0.57436,-1.36,0.126,1058,0.366,"buparlisib, idelalisib, NVP.BEZ235, BGT226, voxtalisib, GDC.0941, PI3K.IN.2, PI.103, PIK.75, PF.05212384, PF.04691502, alpelisib, CH5132799, taselisib, GSK2126458, PKI.179, CUDC.907",0.899629454882437,0.436518914605589,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.80291,-1.95,0.00141,1157,0.0773,"GSK461364, GW.843682X, HMN.214, rigosertib, volasertib, BI.2536, NMS.1286937",2.85078088734462,1.11182050608168,TRUE
+"H520","Pearson.est","potassium channel blocker",0.47712,1.3,0.186,760,0.467,"meglitinide, mepivacaine, oleoylethanolamide, ibutilide, ML133, dofetilide",0.730487055782084,0.330683119433888,FALSE
+"H520","Pearson.est","PPAR receptor agonist",0.595,1.61,0.0482,139,0.282,"fenofibrate, S26948",1.31695296176115,0.549750891680639,FALSE
+"H520","Pearson.est","progesterone receptor agonist",0.31828,0.888,0.577,990,0.821,"norethindrone.acetate, melengestrol.acetate, norgestrel, levonorgestrel, norethindrone, dienogest, danazol, nomegestrol.acetate, tanaproget",0.238824186844269,0.0856568428805592,FALSE
+"H520","Pearson.est","proteasome inhibitor",0.34834,0.96,0.446,274,0.792,"ixazomib, ixazomib.citrate, oprozomib",0.350665141287858,0.101274818410506,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.72971,-1.78,0.013,1383,0.17,"harringtonine, thiostrepton, cycloheximide, emetine, tedizolid.phosphate, bruceantin, homoharringtonine, anguidine",1.88605664769316,0.769551078621726,TRUE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.64324,-1.55,0.0564,952,0.287,"AV.412, PP.121, BMS.599626, CP.724714, NVP.TAE226, mubritinib, tyrphostin.A9",1.24872089601666,0.542118103266008,FALSE
+"H520","Pearson.est","RAF inhibitor",-0.47551,-1.13,0.332,1172,0.452,"RAF265, CEP.32496, regorafenib, sorafenib",0.478861916295964,0.344861565188618,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.77201,-1.88,0,1416,0.0918,"regorafenib, sorafenib",Inf,1.03715731879876,TRUE
+"H520","Pearson.est","retinoid receptor agonist",-0.64411,-1.54,0.0603,1197,0.273,"bexarotene, fenretinide, adapalene, adarotene",1.21968268785985,0.563837352959244,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.29074,-0.694,0.821,936,0.886,"clofarabine, pentostatin, LY2334737, fludarabine.phosphate",0.0856568428805592,0.0525662781129492,FALSE
+"H520","Pearson.est","serotonin receptor agonist",-0.49282,-1.2,0.236,1447,0.446,"aripiprazole",0.627087997029893,0.350665141287858,FALSE
+"H520","Pearson.est","serotonin receptor antagonist",-0.55159,-1.32,0.169,1411,0.39,"SB.200646, aripiprazole",0.772113295386326,0.408935392973501,FALSE
+"H520","Pearson.est","sodium channel blocker",0.16028,0.437,1,1218,1,"oxcarbazepine, mepivacaine, benzethonium, lappaconite, quinidine, butamben, mexiletine, ajmaline, triamterene, A.803467, cibenzoline, benzocaine, brivaracetam",0,0,FALSE
+"H520","Pearson.est","src inhibitor",0.29531,0.804,0.701,105,0.873,"dasatinib, PP.2",0.154281982033341,0.0589857562944303,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",-0.51159,-1.21,0.233,1101,0.446,"ketoconazole, posaconazole, chlormidazole",0.632644078973981,0.350665141287858,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",0.71859,1.95,0.00339,408,0.0732,"LY2109761, SB.431542, adaprev, SB.525334, repsox",2.46980030179692,1.13548891894161,TRUE
+"H520","Pearson.est","thymidylate synthase inhibitor",-0.44037,-1.07,0.378,819,0.51,"ftorafur, raltitrexed, trifluridine, doxifluridine, carmofur",0.422508200162775,0.292429823902064,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",-0.64769,-1.56,0.0668,1148,0.304,"exatecan.mesylate, irinotecan, nemorubicin, epirubicin, dexrazoxane, valrubicin, etoposide, SN.38, etoposide.phosphate, daunorubicin, TAS.103, voreloxin, mitoxantrone, teniposide, amonafide, amsacrine, idarubicin, doxorubicin",1.17522353752445,0.517126416391246,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.71085,-1.72,0.0127,1069,0.171,"verubulin, CYT.997, vinblastine, dolastatin.10, flubendazole, BNC105, vincristine, plinabulin, combretastatin.A.4, nocodazole, ABT.751, docetaxel, taltobulin, paclitaxel, parbendazole, vindesine, indibulin, KX2.391, fenbendazole, albendazole, vinorelbine, fosbretabulin, mebendazole",1.89619627904404,0.767003889607846,TRUE
+"H520","Pearson.est","tyrosine kinase inhibitor",-0.52838,-1.27,0.213,1052,0.417,"PP.121, UNC2250, BMS.599626, CP.724714, tyrphostin.AG.99, NVP.TAE226, mubritinib, aminopurvalanol.a, tyrphostin.A9, regorafenib, tivantinib, sorafenib",0.671620396561262,0.379863945026242,FALSE
+"H520","Pearson.est","VEGFR inhibitor",-0.48641,-1.18,0.286,1028,0.433,"linifanib, KI.8751, PD.173074, AEE788, RAF265, golvatinib, nintedanib, foretinib, tivozanib, pazopanib, axitinib, dovitinib, lenvatinib, OSI.930, ENMD.2076, regorafenib, sorafenib",0.543633966870957,0.363512103646635,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",-0.28259,-0.682,0.837,1090,0.881,"calcitriol, maxacalcitol",0.07727454200674,0.0550240915879521,FALSE
diff --git a/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_venn_diagram.pdf b/Examples/cell_corr/Fig5 - Coldren prot/DMEA/DMEA_venn_diagram.pdf
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--- /dev/null
+++ b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_interactive_network.graph.html	
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNVQxNDoxMjoyNSswMTowMDwveG1wOk1ld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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-1978b53d889d051742b1" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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diff --git a/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_mean_results.csv
new file mode 100644
index 0000000..2889312
--- /dev/null
+++ b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_mean_results.csv	
@@ -0,0 +1,182 @@
+"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.672466666666667,1.25558175854102,0.000500902490448373,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.00237269600738703
+"KEGG_O_GLYCAN_BIOSYNTHESIS",0.597333333333333,1.72334585976842,6.29964077415202e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2126, H3255, H1299, H1703",5.66967669673682e-05
+"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.5966,1.16305378821691,0.131233783810938,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1650",0.241041643734376
+"KEGG_SPLICEOSOME",0.545733333333333,1.11641789837387,0.0584208765996686,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.127674486094202
+"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.524466666666667,1.51136810618094,4.6745523473771e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, H2009, H1703",5.25887139079924e-05
+"KEGG_ETHER_LIPID_METABOLISM",0.506933333333333,1.35497277076841,0.00048229690721715,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H2009",0.0023463092783537
+"KEGG_SPHINGOLIPID_METABOLISM",0.500466666666667,1.19246586454088,0.0149998744158875,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H460",0.040908748406966
+"KEGG_VIRAL_MYOCARDITIS",0.4722,1.13090154933386,0.0615437159070151,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.131879391229318
+"KEGG_MISMATCH_REPAIR",0.443066666666667,1.30684912598786,0.00598004614674568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H2009, H358",0.0188843562528811
+"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.4406,1.12519228832866,0.0971748312056591,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1650",0.197930497114806
+"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.440133333333333,1.75886009622575,5.49128974491639e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"HCC95, H2009, HCC15, H1299, H460, H520",1.00243076619302e-05
+"KEGG_CELL_ADHESION_MOLECULES_CAMS",0.431933333333333,1.3744170954921,0.00052659565934736,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2009, H1299, H460",0.00243044150468012
+"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.419333333333333,1.12305505949916,0.100780850160188,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.201561700320376
+"KEGG_ABC_TRANSPORTERS",0.417666666666667,1.43609782131335,0.000127881591164287,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, H358, HCC15, H460",0.000852543941095244
+"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.3892,0.924497485123675,0.736958168918568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.861379677956768
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3855,1.68689486015898,3.93671322667305e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,6,"H1650, H2009, H2126, H358, A549, HCC15",1.59025956229216e-06
+"KEGG_HOMOLOGOUS_RECOMBINATION",0.3756,1.16966166048136,0.0588721241434374,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.127674486094202
+"KEGG_PROTEASOME",0.3662,0.977887314571572,0.614913616422301,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.768642020527876
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.365866666666667,1.25963043711052,0.0189674660830448,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, HCC15",0.0474186652076121
+"KEGG_SELENOAMINO_ACID_METABOLISM",0.352533333333333,1.14550162852454,0.114279589238038,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.218833255987732
+"KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.3522,1.25217098330403,0.0124285162566258,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0360827891321395
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.348538461538461,1.51866633461647,0.000156293697932313,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1703, H460, H520",13,3,"H2009, H2126, H460",0.00100474520099344
+"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.337866666666667,1.11619653074093,0.177021253496053,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.300602128578203
+"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.337,1.24563334435597,0.0220053125676506,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.0535264359753664
+"KEGG_OTHER_GLYCAN_DEGRADATION",0.3186,1.38038766811563,0.00134148542210353,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H3255",0.00536594168841411
+"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.313133333333333,1.01014057484708,0.491903279318528,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.651260540392598
+"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.3126,1.42674458621216,0.000417573693523436,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, A549",0.00214752185240624
+"KEGG_DILATED_CARDIOMYOPATHY",0.290533333333333,1.42279874425959,0.00034186055014046,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.00180984997133185
+"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.285666666666667,1.35629751617444,0.0315973762789953,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0748358911870942
+"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.279090909090909,1.75446547156366,7.43455023563206e-07,"HCC827, HCC95, H1650, H1975, H2009, H3255, H358, H1299, H1703, H460, H520",11,2,"H358, H1299",1.11518253534481e-05
+"KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.2766,1.0493978409409,0.459467442308323,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.621835636206753
+"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.271933333333333,1.16884390175364,0.097865634684543,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.197930497114806
+"KEGG_PYRIMIDINE_METABOLISM",0.269,0.774216654801115,0.999358715563287,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_ARACHIDONIC_ACID_METABOLISM",0.262,1.53702960283789,5.69533906513128e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1299, H1703",5.66967669673682e-05
+"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.258466666666667,1.09405483452722,0.290135685402503,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.435203528103754
+"KEGG_PROTEIN_EXPORT",0.234066666666667,1.05876420325549,0.521478530048017,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H520",0.680189387019153
+"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.233466666666667,1.16404349861449,0.119553500985217,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.226522422919359
+"KEGG_FATTY_ACID_METABOLISM",0.231533333333333,1.16745118384739,0.151131438689147,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.264113193825694
+"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.226466666666667,1.18532695107822,0.0866870294138956,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.179352474649439
+"KEGG_PARKINSONS_DISEASE",0.225,0.946624378666488,0.821673374053166,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.930196272513018
+"KEGG_HUNTINGTONS_DISEASE",0.2226,0.765188286819469,0.998242457247393,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_RNA_DEGRADATION",0.221466666666667,0.864226067205853,0.972753012668788,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.2105,1.66062057677243,0.00103759332982502,"H1975, H2009, H2126, H3255, A549, H1703",6,2,"H2009, H2126",0.00424469998564782
+"KEGG_DNA_REPLICATION",0.206266666666667,1.35642126129578,0.0036669292793307,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0132009454055905
+"KEGG_RIBOSOME",0.204133333333333,1.43509088147589,0.00066677007542013,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00300046533939058
+"KEGG_RIBOFLAVIN_METABOLISM",0.200666666666667,1.5668825585796,3.74679243414228e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H2126, H3255",4.74193122806455e-05
+"KEGG_BASAL_TRANSCRIPTION_FACTORS",0.193533333333333,1.15056233870143,0.197774990012114,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.326600900937437
+"KEGG_ADHERENS_JUNCTION",0.174666666666667,1.01930765485112,0.674131699242546,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.82525522817797
+"KEGG_TRYPTOPHAN_METABOLISM",0.170866666666667,1.3582344036425,0.00426190723965305,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H358, H1299, H520",0.0148072325025254
+"KEGG_TASTE_TRANSDUCTION",0.162333333333333,1.43649288530219,0.000720358012438812,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H1650, H1299, H460",0.00308724862473777
+"KEGG_N_GLYCAN_BIOSYNTHESIS",0.157533333333333,1.09824443458423,0.328691478142679,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.473315728525458
+"KEGG_TIGHT_JUNCTION",0.147666666666667,1.11873459553108,0.272206621331278,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.419639614643691
+"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.142466666666667,1.42883158393076,0.0106360318796106,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.0319080956388317
+"KEGG_LYSOSOME",0.140533333333333,1.23712846466939,0.0538840101293896,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.119742244731977
+"KEGG_PURINE_METABOLISM",0.136466666666667,0.843261937501092,0.995864837135482,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.136066666666667,1.15453289668325,0.192112079070541,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.320186798450901
+"KEGG_FOCAL_ADHESION",0.134333333333333,1.13425354098548,0.251356571294139,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.400390998521638
+"KEGG_GLYCEROLIPID_METABOLISM",0.1306,1.14914538431206,0.215589479816782,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.349604561865053
+"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.119,1.4198468227242,0.000699608559764023,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00307145221359815
+"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.112666666666667,1.54452015972907,0.00043946544653623,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H1703",0.00219732723268115
+"KEGG_CALCIUM_SIGNALING_PATHWAY",0.109666666666667,0.993170080864204,0.807599844192115,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.920050455408738
+"KEGG_ECM_RECEPTOR_INTERACTION",0.101333333333333,1.6218854401444,3.64022213759701e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2009, H1703, H460",9.36057121096375e-06
+"KEGG_RNA_POLYMERASE",0.0995333333333333,1.32231760106838,0.0144541419844746,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0400268547262374
+"KEGG_BASAL_CELL_CARCINOMA",0.0876666666666666,1.46760123363003,0.000223725390327427,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.00134235234196456
+"KEGG_OXIDATIVE_PHOSPHORYLATION",0.0764,0.960801064588443,0.857556532808406,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.962122526998545
+"KEGG_NOTCH_SIGNALING_PATHWAY",0.0738666666666667,1.11540158473892,0.298581848556822,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.441468672114004
+"KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.0522,1.71280464235042,7.26321988954105e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H358, HCC15, H1299",1.11518253534481e-05
+"KEGG_PEROXISOME",0.0457333333333333,1.22158003460779,0.0861926660845922,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.179352474649439
+"KEGG_NON_HOMOLOGOUS_END_JOINING",0.0443333333333335,1.3346889775025,0.00539599643706583,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0173442742619973
+"KEGG_LONG_TERM_POTENTIATION",0.0418,0.921603974445795,0.952099382214413,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_LEISHMANIA_INFECTION",0.0296,1.30123023108354,0.012817604651115,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0366217275746144
+"KEGG_BETA_ALANINE_METABOLISM",0.0198666666666667,1.30399155708631,0.0155232995929428,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0417043869661149
+"KEGG_GNRH_SIGNALING_PATHWAY",-0.00126666666666664,0.936276322663856,0.945947703781824,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.0073333333333333,0.858830239891669,0.994088183674746,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.0124000000000001,1.3125574708506,0.0178351278296087,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H1299",0.0458617572761367
+"KEGG_PHENYLALANINE_METABOLISM",-0.0186000000000001,1.59528214253332,7.85987090755877e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, HCC15, H1299, H520",6.57876531627429e-05
+"KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.0221333333333333,1.29401285413502,0.0174018767922613,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H1299",0.0453962003276383
+"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.0311333333333334,1.17335732388894,0.138514842974093,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.249412963811021
+"KEGG_GAP_JUNCTION",-0.0363333333333333,0.994244269114319,0.807426641030979,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.920050455408738
+"KEGG_APOPTOSIS",-0.0479333333333333,0.951766813177822,0.894386966862529,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.987666589173345
+"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.0579999999999999,1.70118530106847,4.41738767303379e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, HCC15, H1299, H520",1.59025956229216e-06
+"KEGG_LONG_TERM_DEPRESSION",-0.0587333333333334,0.914511771904758,0.972142412341298,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_BASE_EXCISION_REPAIR",-0.0721333333333333,1.12844398979091,0.302796209255759,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.443116403788916
+"KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.0748666666666666,0.890866581855368,0.985357875887122,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_LYSINE_DEGRADATION",-0.076,1.10629639531444,0.387677508380549,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.540945360530999
+"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.0786,0.975603461599903,0.87001614080591,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.966684600895455
+"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.0826,1.14990507682777,0.273000829547311,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.419639614643691
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.0871333333333334,1.34746910203996,0.00720901437328106,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1703, H520",0.022372803227424
+"KEGG_PYRUVATE_METABOLISM",-0.0904666666666667,1.05404783482309,0.609448929852799,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.767138513101425
+"KEGG_SMALL_CELL_LUNG_CANCER",-0.0954000000000001,1.16362302437565,0.1544797215928,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.267368748910616
+"KEGG_ALZHEIMERS_DISEASE",-0.0971333333333334,0.84996528220415,0.992945589270559,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_PRIMARY_IMMUNODEFICIENCY",-0.105066666666667,1.47856699286199,0.000214481722820739,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0013312658657839
+"KEGG_HISTIDINE_METABOLISM",-0.110466666666667,1.38952987253483,0.00225233480124444,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1299, H520",0.00844625550466666
+"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.1122,1.12677512016754,0.299217655543936,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.441468672114004
+"KEGG_OOCYTE_MEIOSIS",-0.124266666666667,1.00400515555497,0.694177112701672,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.838603223397993
+"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.1264,1.42966928243663,0.000294050572850866,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.00160391221555018
+"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.1266,1.39693796774026,0.000986005386901424,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H358",0.00412746441028503
+"KEGG_PANCREATIC_CANCER",-0.1344,0.94337174917572,0.91927466695173,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.135133333333333,1.06864633109012,0.49206351940774,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.651260540392598
+"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.1354,1.24082339021888,0.0431903679961617,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0996700799911424
+"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.136066666666667,1.17018212664688,0.12380227554322,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.232129266643537
+"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.149133333333333,1.08176640379564,0.390807756038077,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.541118431437337
+"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.171733333333333,1.22675905578576,0.0503123936759265,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.113202885770835
+"KEGG_GLUTATHIONE_METABOLISM",-0.172866666666667,1.33162322355981,0.00449320594102581,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0152599447053707
+"KEGG_ENDOCYTOSIS",-0.177933333333333,0.99941114567291,0.722849146881948,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.854041392805905
+"KEGG_MAPK_SIGNALING_PATHWAY",-0.1786,0.920283325938268,0.938647598914148,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_PATHWAYS_IN_CANCER",-0.180866666666667,0.914254721200878,0.953985812142981,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.189933333333333,1.03581965244001,0.557435029426145,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.721858311487094
+"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.192133333333333,0.969695376811462,0.799982751977542,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.920050455408738
+"KEGG_OLFACTORY_TRANSDUCTION",-0.1978,1.18894972860204,0.112746934755932,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.218833255987732
+"KEGG_TYROSINE_METABOLISM",-0.202,1.51690097614464,4.05733068740359e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.000292127809493058
+"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.2034,1.11598821038319,0.26031303266817,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.411020577897111
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.212066666666667,1.67432794477864,6.01024237406851e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2126, H1299, H1703, H520",5.66967669673682e-05
+"KEGG_RENAL_CELL_CARCINOMA",-0.2204,0.902843982725065,0.947458763274857,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.222866666666667,1.44972799747631,0.000245648202857858,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, HCC15",0.00138177114107545
+"KEGG_BLADDER_CANCER",-0.227666666666667,1.20031886636526,0.0687365930445618,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.145559844094366
+"KEGG_WNT_SIGNALING_PATHWAY",-0.234333333333333,0.882469883473705,0.973589770774693,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_PROPANOATE_METABOLISM",-0.239933333333333,1.24058761806462,0.0330158472644251,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0771799026960586
+"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.239933333333333,1.12201607237449,0.237410048316255,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.381551863365409
+"KEGG_CELL_CYCLE",-0.2414,0.901784722488846,0.942204852693699,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_P53_SIGNALING_PATHWAY",-0.241466666666667,1.07226328501024,0.383286612107163,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.540945360530999
+"KEGG_ENDOMETRIAL_CANCER",-0.245733333333333,1.0943073782513,0.275097080710864,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.419639614643691
+"KEGG_RETINOL_METABOLISM",-0.247266666666667,1.45355006138501,0.000243037101879537,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.00138177114107545
+"KEGG_AXON_GUIDANCE",-0.253733333333333,1.13440711177165,0.183271886161668,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.308307845879442
+"KEGG_VIBRIO_CHOLERAE_INFECTION",-0.253866666666667,1.09722948938723,0.278079211768368,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.420624017800893
+"KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.26,1.87014132391875,1.10407926508619e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,7,"HCC95, H2126, H358, HCC44, H1299, H1703, H460",6.62447559051712e-07
+"KEGG_VEGF_SIGNALING_PATHWAY",-0.2644,1.15344742898347,0.146441959805773,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.258426987892541
+"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.272,1.06757937142196,0.386926042887952,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.540945360530999
+"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.276666666666667,1.57274857979211,3.95160935672046e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC15, H1299, H520",4.74193122806455e-05
+"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.295933333333333,1.01091538904575,0.592292149000059,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.750792864929652
+"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.299133333333333,1.28948460726794,0.00503906090386486,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0167968696795495
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.326333333333333,1.36110048262776,0.00199494835292233,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H358",0.00780631964186998
+"KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.3408,1.33415239009642,0.00261866809934526,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00961959709963565
+"KEGG_MELANOGENESIS",-0.3648,1.02314341963522,0.463669447659153,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.622839556557072
+"KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.3684,1.60445299089752,2.57688292181552e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H358",7.73064876544657e-06
+"KEGG_BUTANOATE_METABOLISM",-0.368533333333333,1.25607380735521,0.0135588420451466,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0381342432519748
+"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.373333333333333,1.22760042746971,0.0181010826865845,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0458900687828902
+"KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.3742,0.922040841983539,0.767565887597776,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.891366837210321
+"KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.374266666666667,1.12830368674564,0.113906497442392,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.218833255987732
+"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.382266666666667,1.29509025977048,0.00517100200515832,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H1299",0.016923279289609
+"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.390666666666667,1.0743129809103,0.213427372510628,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.349244791381027
+"KEGG_INSULIN_SIGNALING_PATHWAY",-0.396266666666667,0.88325683586103,0.860565149148699,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.962122526998545
+"KEGG_THYROID_CANCER",-0.3978,1.25931036682781,0.0101030288735249,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0308227999531268
+"KEGG_SULFUR_METABOLISM",-0.4,2.04643028786151,1.19572476198374e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,7,"HCC95, H1650, H2126, H358, HCC15, HCC44, H1299",9.35784596335104e-05
+"KEGG_TYPE_II_DIABETES_MELLITUS",-0.403533333333333,1.23808491900462,0.0202899206961409,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0500299414425391
+"KEGG_MELANOMA",-0.416933333333333,1.0923707158984,0.138562757672789,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.249412963811021
+"KEGG_ERBB_SIGNALING_PATHWAY",-0.419733333333333,0.916319849543088,0.71030482518822,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.846720983668077
+"KEGG_MTOR_SIGNALING_PATHWAY",-0.429666666666667,1.10164770533355,0.113889082322761,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.218833255987732
+"KEGG_COLORECTAL_CANCER",-0.432266666666667,0.778052189460199,0.978980800784636,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999358715563287
+"KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.436333333333333,0.916668865798228,0.725935183885019,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.854041392805905
+"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.4488,0.920264496140725,0.663299471668763,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.817766471920393
+"KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.450666666666667,0.922043976846059,0.708672773067062,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.846720983668077
+"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.470066666666667,0.970082946870794,0.436500452392577,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.595227889626242
+"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.489466666666667,1.21064804763321,0.0122229442037023,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0360677042076463
+"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.49,1.95793258310903,9.27721093641987e-05,"H1975, H3255, H358, A549, H1299",5,2,"H1975, H1299",0.000642268449444452
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.507142857142857,1.77050809122661,5.69515359142858e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,5,"H2009, H2126, H1299, H1703, H520",5.66967669673682e-05
+"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.517,0.977805852771544,0.33304824077881,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.475783201112586
+"KEGG_PROSTATE_CANCER",-0.525666666666667,0.909425145483725,0.583921056863997,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.750755644539424
+"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.531733333333333,0.892335256237144,0.588682540518253,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.750792864929652
+"KEGG_ACUTE_MYELOID_LEUKEMIA",-0.533666666666667,0.900569951805654,0.625309408167842,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.776246161863528
+"KEGG_GLIOMA",-0.534466666666667,0.949296345922048,0.4364529919426,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.595227889626242
+"KEGG_GALACTOSE_METABOLISM",-0.537666666666667,1.03971704026121,0.161343318269021,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.276588545604036
+"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.551066666666667,0.856866256163925,0.678543187612998,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.82525522817797
+"KEGG_PRION_DISEASES",-0.553266666666667,1.18850058396925,0.0158805767090788,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H460",0.0420368207005027
+"KEGG_REGULATION_OF_AUTOPHAGY",-0.57,1.22758875151947,0.00427764494517401,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H358",0.0148072325025254
+"KEGG_PPAR_SIGNALING_PATHWAY",-0.573733333333333,1.12748275036958,0.0272427021859196,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.065382485246207
+"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.585266666666667,0.993933129876788,0.145892608654356,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.258426987892541
+"KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.617933333333333,0.92948560787034,0.271447178008282,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.419639614643691
+"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.6494,0.894009092315541,0.313361883556529,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.4548801535498
+"KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.657333333333333,1.01798418923076,0.0437791676616006,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0997500022669382
+"KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.671666666666667,0.821736807592541,0.497959745751588,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.654253680549531
+"KEGG_NITROGEN_METABOLISM",-0.678,1.37687638204327,2.46248764504406e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, HCC44",0.000184686573378305
+"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.712866666666667,0.931559818389617,0.126674459768679,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.235066007818167
+"KEGG_STEROID_BIOSYNTHESIS",-0.732666666666667,1.55873330746781,7.6032554449495e-09,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H2126, A549, HCC44, H1299, H1703",6.62447559051712e-07
+"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.824857142857143,1.50804712521464,2.41916465052312e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,5,"H1975, H358, HCC15, HCC44, H1299",3.34961259303202e-05
+"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.869166666666667,1.52003264518373,4.42753468165306e-07,"HCC827, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",12,3,"H1975, H358, H520",9.96195303371939e-06
+"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.994466666666667,1.21069135306277,8.04071316433524e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",6.57876531627429e-05
+"KEGG_LINOLEIC_ACID_METABOLISM",-1.0025,1.61471101645671,0.00212062380868656,"H1975, H3255, H358, H1299",4,1,"H1299",0.00812153799071449
+"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-1.0076,1.28774358583421,5.56905981218346e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2126, A549, HCC44",1.00243076619302e-05
+"KEGG_FOLATE_BIOSYNTHESIS",-1.04933333333333,1.42717736742678,8.357376828612e-10,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"HCC95, H1650, H358, A549, H1299, H1703",1.50432782915016e-07
+"KEGG_TYPE_I_DIABETES_MELLITUS",-1.75,NA,NA,"HCC15",1,0,"",NA
diff --git a/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..e6d329f
--- /dev/null
+++ b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_results.csv	
@@ -0,0 +1,2659 @@
+"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"HCC827","Input","KEGG_ABC_TRANSPORTERS",0.54049,1.55,0.0721,1185,0.411,"ABCA12, ABCC3, ABCC2, ABCA3, ABCG2, ABCB7, ABCD3, TAP2",1.14206473528057,0.386158178123931,FALSE
+"HCC827","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.39562,-1.17,0.299,5858,0.601,"RELA, BRAF, STAT5A, BAD, SOS1, CCND1, IKBKG, RPS6KB2, MAP2K1, MTOR, AKT1, CHUK, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, RPS6KB1, TCF7L1, AKT2, MAPK1, PIK3CB",0.52432881167557,0.22112552799726,FALSE
+"HCC827","Input","KEGG_ADHERENS_JUNCTION",0.43356,1.24,0.202,1419,0.599,"EGFR, CDH1, CTNNB1, CTNND1, RAC2, TGFBR2, CTNNA1, CTNNA2, MET, LMO7, TJP1, PTPRF, PTPRJ, AFDN, RAC3, PARD3, SRC, NECTIN4",0.694648630553376,0.222573177610689,FALSE
+"HCC827","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.38221,-1.13,0.251,5467,0.614,"STAT3, PTPN11, PRKAA1, PRKAG1, RELA, RXRG, ACACB, ADIPOR2, PRKCQ, IKBKG, ACSL1, MTOR, STK11, MAPK8, AKT1, NFKBIB, CHUK, AKT3, IKBKB, MAPK9, IRS2, AKT2, CPT1A",0.600326278518962,0.211831628858832,FALSE
+"HCC827","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.30791,-0.904,0.51,6277,0.766,"ASS1, ADSL, ASL, CAD, PPAT, CPS1, NIT2, GLUD2",0.292429823902064,0.115771230367396,FALSE
+"HCC827","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.26484,-0.797,0.686,7350,0.815,"MAPK3, IRS2, MAPK1, PIK3CB, ATP1B3",0.163675884293248,0.0888423912600234,FALSE
+"HCC827","Input","KEGG_ALZHEIMERS_DISEASE",-0.24201,-0.743,0.786,6859,0.865,"NDUFS5, NDUFB3, NAE1, NDUFA6, ITPR2, NDUFA9, CASP3, NDUFB4, CAPN1, NDUFV3, MAPK3, NDUFS7, NDUFA2, IDE, GSK3B, NDUFB7, CASP9, MAPK1, ITPR1, ATP2A1, PSEN2, ATP2A3, MAPT, SNCA, MME, BID",0.104577453960592,0.0629838925351858,FALSE
+"HCC827","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.3628,1.01,0.397,1945,0.728,"PARS2, MARS2, TARS2, AARS2, YARS2, WARS2, FARS2",0.401209493236885,0.137868620686963,FALSE
+"HCC827","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.39724,-1.2,0.22,7420,0.612,"UAP1, GALK1, NPL, GNPDA2, HK3, PGM3, GCK, GNE",0.657577319177794,0.213248577854439,FALSE
+"HCC827","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.59984,-1.74,0.0367,7111,0.312,"CASP3, ALS2, MAPK14, BCL2L1, BAX, SOD1, CASP9, NEFL, NEFM, PRPH, PRPH2, NEFH, BID",1.43533393574791,0.505845405981557,FALSE
+"HCC827","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.48545,1.36,0.129,1185,0.51,"CTSS, B2M, IFI30, LGMN, TAPBP, CREB1, PSME2, TAP2",0.889410289700751,0.292429823902064,FALSE
+"HCC827","Input","KEGG_APOPTOSIS",-0.27932,-0.84,0.6,5858,0.773,"RELA, ATM, PRKACB, BIRC2, BAD, RIPK1, APAF1, IKBKG, IRAK4, PRKAR2B, PRKAR1A, DFFB, AKT1, CHUK, CASP3, XIAP, CAPN1, TNFRSF10D, BCL2L1, AKT3, BAX, IKBKB, AKT2, CASP9, PIK3CB, BID",0.221848749616356,0.111820506081675,FALSE
+"HCC827","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.62342,1.78,0.0311,1027,1,"PTGS2, PTGES, GGT7, EPHX2, ALOX5, GGT1, GPX6, GPX7, PLA2G12A",1.50723961097316,0,FALSE
+"HCC827","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34364,0.975,0.454,796,0.788,"PRODH, PRODH2, OAT, GATM, AGMAT, ALDH1B1, LAP3",0.342944147142896,0.103473782510445,FALSE
+"HCC827","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.60072,1.69,0.0556,545,0.439,"ITGB6, ITGA1, DSC2, ITGA3, ITGA2, ITGA5, DSG2, CTNNB1, ITGB1, CTNNA1, GJA1, CTNNA2, ITGAV",1.25492520841794,0.357535479757879,FALSE
+"HCC827","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.52864,1.52,0.0668,786,0.375,"UGDH, ALDH1B1",1.17522353752445,0.425968732272281,FALSE
+"HCC827","Input","KEGG_AXON_GUIDANCE",0.4022,1.15,0.275,1664,0.637,"EPHB2, SEMA4B, ITGB1, RAC2, NRP1, EPHA1, EFNA5, EFNB2, MET, CFL2, SEMA3A, CXCR4, EFNA1, PLXNB3, PLXNB2, RAC3, PLXNB1, GNAI1, GNAI3, ROBO1, SLIT1, SLIT3, GNAI2, KRAS, NRAS, NTN4",0.560667306169737,0.19586056766465,FALSE
+"HCC827","Input","KEGG_BASAL_CELL_CARCINOMA",0.42377,1.2,0.242,338,0.638,"CTNNB1, TP53",0.616184634019569,0.195179321278838,FALSE
+"HCC827","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.24193,-0.713,0.832,4917,0.885,"TAF6, GTF2A1, TAF6L, TAF1, GTF2F1, TAF10, GTF2H2, TAF12, GTF2H4, GTF2H1, GTF2F2, GTF2IRD1, TAF2, TBPL1",0.0798766737092761,0.0530567293021746,FALSE
+"HCC827","Input","KEGG_BASE_EXCISION_REPAIR",-0.37347,-1.13,0.267,6755,0.614,"MUTYH, LIG3, NTHL1, PARP1, FEN1, HMGB1, MPG",0.573488738635425,0.211831628858832,FALSE
+"HCC827","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29755,-0.878,0.539,6702,0.785,"ALDH7A1, ALDH2, SRM, EHHADH",0.268411234813261,0.105130343254747,FALSE
+"HCC827","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.2539,0.72,0.816,2400,0.975,"ACOX3, SCD5, PECR, ACAA1, FADS1, ELOVL6, ACOT2, HADHA, ACOX1",0.0883098412461389,0.0109953843014632,FALSE
+"HCC827","Input","KEGG_BLADDER_CANCER",0.4753,1.35,0.135,338,0.503,"CDKN2A, EGFR, CDH1, CDK4, TP53",0.869666231504994,0.298432014944073,FALSE
+"HCC827","Input","KEGG_BUTANOATE_METABOLISM",0.36724,1.04,0.37,786,0.695,"ACSM3, ACADS, HMGCL, BDH2, ALDH1B1",0.431798275933005,0.158015195409886,FALSE
+"HCC827","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.286,-0.876,0.555,6577,0.777,"MAP2K1, BLNK, NFAT5, AKT1, SYK, NFKBIB, CHUK, CD22, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, AKT2, MAPK1, PIK3CB, CD81, PLCG2",0.255707016877324,0.109578981199086,FALSE
+"HCC827","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.23319,0.676,0.885,615,0.972,"TNNC1, EGFR, PLCB4, P2RX4, CAMK2D, ERBB3",0.0530567293021746,0.0123337350737254,FALSE
+"HCC827","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.45321,1.26,0.186,2323,0.605,"TNNC1, COX6A1, COX7A2, COX7C, COX5B, COX5A, UQCRH, COX6B1, COX6C, COX7A2L, ATP2A2, COX4I1, SLC9A6, UQCRFS1, COX7B, UQCRB, ATP1B1, UQCRC2, UQCRC1",0.730487055782084,0.218244625347531,FALSE
+"HCC827","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.39319,1.11,0.302,592,0.664,"ITGB2, CDH1, CDH15, CDH3, OCLN, CLDN6, CD274, CLDN3, CLDN4, ICAM1, ALCAM, ITGB1, F11R, SDC1, ITGAV, CD276, CNTN1",0.519993057042849,0.177831920631982,FALSE
+"HCC827","Input","KEGG_CELL_CYCLE",0.25369,0.723,0.804,926,0.999,"CDKN2A, FZR1, CDK4, TP53, ZBTB17, TFDP2, TGFB2, E2F3, CDC20, CCNA2, CCNB1",0.0947439512515487,0.000434511774017692,FALSE
+"HCC827","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.29394,0.855,0.607,1649,0.861,"CXCL5, CX3CL1, PLCB4, RAC2, LYN, GNG12, STAT1, GNG4, ARRB1, CXCR4, GNB3, GNAI1, PIK3R3, STAT2, GNAI3, GNB2, PARD3, PRKCB, RAP1A, GNAI2, KRAS, NRAS, ADCY9",0.216811308924742,0.0649968485463452,FALSE
+"HCC827","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.26282,0.75,0.794,704,0.967,"CDKN2A, CDK4, TGFBR2, TP53, TGFB2, E2F3",0.100179497572904,0.0145735259169983,FALSE
+"HCC827","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.36444,1.05,0.37,2236,0.689,"DLST, DLAT, SUCLG2, SDHC, OGDHL, PDHB, PDHA1, OGDH, SUCLG1, CS, MDH2, SDHA, SDHB",0.431798275933005,0.161780778092374,FALSE
+"HCC827","Input","KEGG_COLORECTAL_CANCER",-0.25449,-0.768,0.719,6269,0.839,"MSH2, CCND1, APPL1, MAP2K1, SMAD4, MAPK8, AKT1, MSH6, SMAD2, CASP3, MAPK3, RAF1, AKT3, BAX, GSK3B, MAPK9, TCF7L1, AKT2, CASP9, MAPK1, PIK3CB",0.143271109617117,0.0762380391712997,FALSE
+"HCC827","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.59971,1.72,0.0326,706,0.677,"CFB, SERPINA1, CFI, MBL2, SERPINC1, PROS1, PLAU, TFPI, SERPINF2, F3, F8",1.48678239993206,0.169411331314856,FALSE
+"HCC827","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.27524,-0.835,0.631,7177,0.772,"SRM, MAT1A, AHCY, SDS, APIP",0.199970640755866,0.112382699664264,FALSE
+"HCC827","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.52324,1.48,0.0911,993,0.409,"CXCL5, EGFR, CX3CL1, TGFBR2, TNFRSF10B, IL6ST, IL10RB, OSMR, MET, TNFRSF10A, LTBR, IL18, TGFB2, CXCR4, TNFRSF21, IL1RAP",1.040481623027,0.388276691992658,FALSE
+"HCC827","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.25404,-0.755,0.754,5858,0.854,"RELA, POLR3A, POLR3B, IRF3, RIPK1, POLR3D, IKBKG, NFKBIB, CHUK, TREX1, POLR3C, IKBKB, PYCARD",0.122628654130226,0.068542129310995,FALSE
+"HCC827","Input","KEGG_DILATED_CARDIOMYOPATHY",0.51379,1.47,0.0779,660,0.401,"ITGB6, TNNC1, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, ITGAV, TGFB2",1.10846254232744,0.396855627379818,FALSE
+"HCC827","Input","KEGG_DNA_REPLICATION",-0.22458,-0.672,0.869,5811,0.925,"POLA2, MCM7, MCM2, PRIM1, RNASEH2A, PRIM2, RNASEH1, FEN1, RNASEH2C, RNASEH2B",0.0609802235513335,0.0338582672609674,FALSE
+"HCC827","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.5855,1.67,0.0392,412,0.333,"EGFR, ETS2, ETS1, ETV6",1.40671393297954,0.47755576649368,FALSE
+"HCC827","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.35448,-1.03,0.358,7065,0.667,"MGST2, GSTM2, GSTO1, GSTA4, ALDH3A1, GSTT2, GSTM4, MAOA, GSTM3, MAOB",0.446116973356126,0.175874166083451,FALSE
+"HCC827","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.32803,-0.997,0.392,6831,0.705,"UMPS, GMPS, IMPDH1, CES1, CES2, TPMT, UCK2",0.406713932979543,0.151810883008601,FALSE
+"HCC827","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.58515,1.69,0.0261,1235,0.439,"ITGB6, TNC, ITGA1, LAMB3, ITGA3, ITGA2, LAMC2, ITGA5, ITGB1, CD47, SDC1, ITGAV, LAMB1, ITGA6, SDC4, LAMA5, COL5A1, AGRN",1.58335949266172,0.357535479757879,FALSE
+"HCC827","Input","KEGG_ENDOCYTOSIS",0.22512,0.65,0.898,1759,0.942,"EGFR, RAB11FIP1, RAB31, EPN3, EPN2, MET, ERBB3, RAB11A, ACAP1, ARRB1, CXCR4, RAB11B, EHD1, RAB11FIP5, STAM2, PLD2, PARD3, RAB5B, PSD, SRC, LDLR, CHMP2B, EHD4, PLD1, EHD3, CLTA, AGAP1, RAB22A, RUFY1, RAB5A",0.0467236633326956,0.0259490972071227,FALSE
+"HCC827","Input","KEGG_ENDOMETRIAL_CANCER",0.38834,1.11,0.296,425,0.664,"EGFR, CDH1, CTNNB1, TP53, CTNNA1, CTNNA2",0.528708288941061,0.177831920631982,FALSE
+"HCC827","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.26233,0.75,0.78,810,0.967,"EGFR, LYN, F11R, JUN, MET, TCIRG1, TJP1, ADAM17",0.10790539730952,0.0145735259169983,FALSE
+"HCC827","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.28031,-0.851,0.571,5895,0.783,"BRAF, PAK3, STAT5A, NCK2, PTK2, CRK, BAD, CAMK2G, SOS1, NCK1, RPS6KB2, HBEGF, MAP2K1, MTOR, MAPK8, CBL, AKT1, SHC1, PLCG1, ABL2, MAPK3, RAF1, MAP2K2, AKT3, GSK3B, MAPK9, RPS6KB1, AKT2, MAPK1, CRKL, PIK3CB, PLCG2",0.243363891754152,0.106238237942057,FALSE
+"HCC827","Input","KEGG_ETHER_LIPID_METABOLISM",0.58793,1.67,0.0486,1722,0.333,"LPCAT1, PLPP2, PLPP1, PAFAH2, PLA2G12A, PLD2, LPCAT4, PLD1, PLPP3, AGPS",1.31336373073771,0.47755576649368,FALSE
+"HCC827","Input","KEGG_FATTY_ACID_METABOLISM",0.30824,0.88,0.597,1362,0.825,"ACADS, ACSL4, CPT2, ACADVL, ALDH1B1, ACOX3, ACAA1, ACADM",0.224025668870631,0.0835460514500749,FALSE
+"HCC827","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34275,-0.99,0.41,6577,0.706,"MAP2K1, MAPK8, AKT1, SYK, PLCG1, PRKCD, MAPK14, MAPK3, RAF1, MAP2K2, AKT3, MAPK9, AKT2, MAPK1, PIK3CB, PLCG2",0.387216143280265,0.151195298948196,FALSE
+"HCC827","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.2418,0.695,0.861,552,0.985,"MARCKS, PLPP2, RAC2, LYN, MARCKSL1, AMPH, PLPP1, CFL2",0.0649968485463452,0.00656376950238827,FALSE
+"HCC827","Input","KEGG_FOCAL_ADHESION",0.33014,0.937,0.505,545,0.792,"ITGB6, TNC, EGFR, ITGA1, LAMB3, ITGA3, ITGA2, LAMC2, ITGA5, CTNNB1, ITGB1, RAC2, JUN, MET, ITGAV",0.296708621881339,0.101274818410506,FALSE
+"HCC827","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.61361,-1.81,0.0267,6548,0.354,"ALPI, ALPP, GGH, DHFR",1.57348873863542,0.450996737974212,FALSE
+"HCC827","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.49287,-1.52,0.0786,6011,0.42,"GMDS, ALDOA, PMM1, PFKFB4, ALDOC, PMM2, PFKL, PFKM, PFKFB3, MTMR6, PFKP, MTMR2, AKR1B1, HK3",1.10457745396059,0.3767507096021,FALSE
+"HCC827","Input","KEGG_GALACTOSE_METABOLISM",-0.40012,-1.18,0.233,7624,0.597,"GALK1, PFKP, AKR1B1, HK3, GCK",0.632644078973981,0.224025668870631,FALSE
+"HCC827","Input","KEGG_GAP_JUNCTION",-0.29238,-0.848,0.594,6779,0.778,"CDK1, ADCY5, ADCY6, ITPR2, CSNK1D, TUBA1B, TUBB1, TUBA3C, TUBB, MAPK3, RAF1, TUBB2A, MAP2K2, TUBB6, TUBAL3, MAPK1, ITPR1, TUBB2B",0.226213555018806,0.109020403010311,FALSE
+"HCC827","Input","KEGG_GLIOMA",0.31413,0.894,0.565,704,0.81,"CDKN2A, EGFR, CDK4, TP53, CAMK2D, E2F3",0.247951552180562,0.0915149811213502,FALSE
+"HCC827","Input","KEGG_GLUTATHIONE_METABOLISM",-0.37778,-1.14,0.278,6961,0.624,"GGCT, MGST2, GSTM2, SRM, PGD, GSTO1, GSTA4, IDH2, RRM2B, GCLM, ANPEP, RRM2, RRM1, GSTT2, GSTM4, GSTM3",0.555955204081924,0.204815410317576,FALSE
+"HCC827","Input","KEGG_GLYCEROLIPID_METABOLISM",0.38497,1.1,0.323,1248,0.667,"LPL, PLPP2, MGLL, PLPP1, ALDH1B1, GLA, GPAT3, MBOAT2, MBOAT1",0.490797477668897,0.175874166083451,FALSE
+"HCC827","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33079,0.95,0.476,1567,0.811,"LPCAT1, PEMT, PLPP2, PLPP1, GPD2, GPAT3, PLA2G12A, CDS1, PLD2, LPCAT4, MBOAT2, MBOAT1, PISD, PLD1, PLPP3",0.322393047279507,0.090979145788844,FALSE
+"HCC827","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.33729,-1.01,0.384,7312,0.693,"PHGDH, SDS, GCAT, MAOA, MAOB",0.415668775632469,0.159266765388193,FALSE
+"HCC827","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.27023,-0.808,0.701,6478,0.804,"ALDOC, BPGM, GPI, PFKL, ALDH7A1, ALDH2, PKLR, PFKM, PKM, PFKP, ACSS2, HK3, ALDH3A1, ACSS1, GCK",0.154281982033341,0.0947439512515487,FALSE
+"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.6485,-1.92,0.0242,7319,0.611,"CHST14, CHPF, CHST12",1.61618463401957,0.213958789757446,FALSE
+"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.31616,-0.944,0.465,5041,0.735,"HS3ST1, EXT1, B3GALT6, EXTL2, EXT2, GLCE",0.332547047110046,0.133712660915805,FALSE
+"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.40808,-1.23,0.214,6954,0.631,"B3GNT2, B4GAT1, B4GALT4, ST3GAL1",0.669586226650809,0.199970640755866,FALSE
+"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.63815,1.83,0.0189,1502,1,"GNS, HPSE, IDS, HEXB, SGSH, HEXA",1.72353819582676,0,FALSE
+"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.3095,-0.904,0.536,7834,0.766,"ST3GAL1",0.27083521030723,0.115771230367396,FALSE
+"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.59506,1.65,0.0482,1502,0.329,"B3GALT5, GLA, HEXB, HEXA",1.31695296176115,0.482804102050026,FALSE
+"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.44013,-1.32,0.16,6954,0.514,"B3GNT2, B4GAT1, B4GALT4, FUT3, ST3GAL4",0.795880017344075,0.289036881004724,FALSE
+"HCC827","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.64256,-1.91,0.0228,7997,0.476,"PGAP1, PIGM, PIGX",1.64206515299955,0.322393047279507,FALSE
+"HCC827","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.25109,-0.74,0.778,2075,0.86,"CS, MDH2, MTHFD1L, MTHFD1, ACO2, MTHFD2, ACO1, PGP, MDH1, GRHPR",0.109020403010311,0.0655015487564323,FALSE
+"HCC827","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.22789,0.651,0.912,1649,0.965,"EGFR, PLCB4, JUN, CAMK2D, GNAQ, PLA2G12A, PLD2, MAP2K4, PRKCB, ITPR3, SRC, PLD1, KRAS, NRAS, ADCY9",0.0400051616715838,0.0154726866562074,FALSE
+"HCC827","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.24669,0.701,0.844,929,0.991,"CSNK1G1, LRP2",0.073657553374345,0.00392634551472468,FALSE
+"HCC827","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.42532,1.22,0.219,201,0.619,"ITGA1, ITGA3, ITGA2, ITGA5",0.659555885159882,0.208309350979882,FALSE
+"HCC827","Input","KEGG_HISTIDINE_METABOLISM",-0.49187,-1.45,0.107,7840,0.4,"METTL2B, ALDH3A1, BUD23, LCMT1, MAOA, MAOB",0.97061622231479,0.397940008672038,FALSE
+"HCC827","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.20486,-0.599,0.933,6866,0.984,"BLM, TOP3B, MUS81",0.0301183562535,0.00700490156865849,FALSE
+"HCC827","Input","KEGG_HUNTINGTONS_DISEASE",0.23112,0.657,0.893,2330,0.983,"PLCB4, SOD2, COX6A1, TP53, COX7A2, CREB1, COX7C, ATP5PF, COX5B, COX5A, GNAQ, UQCRH, COX6B1, NDUFB1, DLG4, COX6C, COX7A2L, ATP5MC2, RCOR1, COX4I1, HTT, NDUFB10, CLTA, SDHC, POLR2D, SLC25A5, SLC25A31, UQCRFS1, CREB5, GPX1, CASP8, POLR2K, COX7B, TFAM, POLR2L, UQCRB, AP2B1, SDHA, SDHB, TAF4, UQCRC2, UQCRC1, CLTB",0.0491485411114536,0.00744648216786438,FALSE
+"HCC827","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.53826,1.54,0.0647,660,0.37,"ITGB6, TNNC1, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, ACE, ITGAV, TGFB2",1.1890957193313,0.431798275933005,FALSE
+"HCC827","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.37439,-1.12,0.275,7479,0.618,"CDIPT, PLCD3, PIP5K1A, OCRL, IMPA2, ITPKB, PIK3CB, ITPK1, PLCG2, ITPKA",0.560667306169737,0.209011524911184,FALSE
+"HCC827","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.39484,-1.19,0.233,5975,0.595,"TSC1, ACACB, PRKACB, EIF4E2, CRK, PHKG2, BAD, ACACA, INPP5D, PRKCI, SOS1, RPS6KB2, MAP2K1, PRKAR2B, MTOR, MAPK8, PRKAR1A, PHKB, CBL, AKT1, SHC1, PKLR, GYS1, RPTOR, MAPK3, RAF1, PPP1R3D, MAP2K2, AKT3, IKBKB, GSK3B, MAPK9, RPS6KB1, IRS2, AKT2, MAPK1, CRKL, PIK3CB, HK3, SORBS1, GCK",0.632644078973981,0.22548303427145,FALSE
+"HCC827","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.5027,-1.48,0.0916,8256,0.394,"CD40",1.03810452633215,0.404503778174426,FALSE
+"HCC827","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.25171,0.721,0.821,1605,0.988,"IRF9, IL6ST, STAT1, IL10RB, OSMR, STAM2, PIK3R3, STAT2, JAK1, IFNGR1, SPRY1, IL13RA1",0.0856568428805592,0.00524305541237188,FALSE
+"HCC827","Input","KEGG_LEISHMANIA_INFECTION",0.59025,1.68,0.0369,1357,0.401,"PTGS2, ITGB2, ITGB1, MARCKSL1, JUN, STAT1, CYBA, TGFB2, NCF2, JAK1, PRKCB, IFNGR1",1.43297363384094,0.396855627379818,FALSE
+"HCC827","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.37798,1.08,0.31,434,0.66,"ITGB2, OCLN, CLDN6, CLDN3, CLDN4, ICAM1, CTNNB1, CTNND1, ITGB1, RAC2, F11R, CTNNA1, CTNNA2, CYBA",0.508638306165727,0.180456064458131,FALSE
+"HCC827","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.46478,-1.38,0.118,6702,0.444,"ALDH7A1, ALDH2, EHHADH",0.928117992693875,0.35261702988538,FALSE
+"HCC827","Input","KEGG_LONG_TERM_DEPRESSION",0.28927,0.824,0.658,1585,0.88,"PLCB4, LYN, GNAQ, PLA2G12A, GNAI1, GNAI3, PRKCB, ITPR3, GNAI2, KRAS, NRAS",0.181774106386044,0.0555173278498314,FALSE
+"HCC827","Input","KEGG_LONG_TERM_POTENTIATION",-0.17933,-0.551,0.99,6899,0.99,"RPS6KA1, ITPR2, MAPK3, RAF1, MAP2K2, MAPK1, ITPR1, CAMK4",0.00436480540245009,0.00436480540245009,FALSE
+"HCC827","Input","KEGG_LYSINE_DEGRADATION",0.2399,0.681,0.884,2365,0.979,"TMLHE, PLOD2, DLST, PIPOX, ALDH1B1, SETDB1, EHMT1, SETD2, EHMT2, SETD1B, GCDH, OGDHL, OGDH, SETD1A, ECHS1, HADH, HADHA",0.0535477349869269,0.00921730819686218,FALSE
+"HCC827","Input","KEGG_LYSOSOME",0.53598,1.54,0.0865,1582,0.37,"GNS, CTSS, NAPSA, CTSK, CTSO, CTSH, CTSC, AP1M2, IDS, NPC2, FUCA1, LGMN, GAA, AGA, SUMF1, CTSV, AP1B1, TCIRG1, AP1S1, GLA, AP1S3, GALC, PSAP, HEXB, CLN5, IGF2R, LAMP2, GGA3, CD63, ASAH1, SCARB2, M6PR, SGSH, HEXA, AP1G1, LAMP1",1.06298389253519,0.431798275933005,FALSE
+"HCC827","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.26069,-0.792,0.703,7088,0.814,"RPS6KA5, CASP3, RELB, NFKB2, MAPK14, MAPKAPK2, MAPK3, RASA1, CD14, TAOK2, RAF1, FLNA, MAP3K11, PPP5C, MAP2K2, AKT3, IKBKB, MAPK9, STK4, AKT2, NLK, MAPK1, CRKL, HSPA2, HSPA1L, STMN1, FGFR1, MAPT, FLNB",0.153044674980176,0.0893755951107988,FALSE
+"HCC827","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.63536,-1.94,0.0155,6310,0.836,"IAPP, PKLR, MNX1, GCK",1.80966830182971,0.0777937225609836,FALSE
+"HCC827","Input","KEGG_MELANOGENESIS",0.23385,0.655,0.892,1649,0.973,"CTNNB1, PLCB4, CAMK2D, CREB1, GNAQ, GNAI1, GNAI3, ASIP, PRKCB, GNAI2, KRAS, NRAS, ADCY9",0.0496351456238769,0.0118871597316481,FALSE
+"HCC827","Input","KEGG_MELANOMA",0.40989,1.19,0.209,704,0.635,"CDKN2A, EGFR, CDH1, CDK4, TP53, MET, E2F3",0.679853713888946,0.197226274708024,FALSE
+"HCC827","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.35663,-1.07,0.328,7065,0.657,"MGST2, GSTM2, GSTO1, GSTA4, AKR1C3, AKR1C1, ALDH3A1, GSTT2, GSTM4, GSTM3",0.484126156288321,0.182434630440219,FALSE
+"HCC827","Input","KEGG_MISMATCH_REPAIR",-0.18696,-0.564,0.974,1543,0.994,"POLD4, SSBP1, RFC1, POLD3, RFC4, LIG1, RFC5, POLD2, POLD1, RFC2, MSH3, RFC3, RPA2, RPA1, PCNA, PMS2, RPA3, MLH3, MLH1, MSH2, MSH6",0.0114410431213845,0.00261361560268669,FALSE
+"HCC827","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.4814,-1.47,0.0933,5510,0.391,"PRKAA1, RHEB, MLST8, TSC2, RPS6, BRAF, TSC1, EIF4E2, RPS6KB2, MTOR, STK11, AKT1, RPS6KA1, RICTOR, RPTOR, MAPK3, AKT3, RPS6KB1, AKT2, MAPK1, PIK3CB",1.0301183562535,0.407823242604133,FALSE
+"HCC827","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.27935,-0.831,0.627,7315,0.77,"TNFRSF10D, MAPK3, IFNAR1, RAF1, MAP2K2, MAPK1, PIK3CB, PRF1, ZAP70, BID, PLCG2",0.202732459169284,0.113509274827518,FALSE
+"HCC827","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.31793,0.927,0.529,538,0.784,"P2RX4, CHRNE",0.276544327964814,0.105683937315562,FALSE
+"HCC827","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.38899,-1.15,0.274,6253,0.622,"MAP3K3, CAMK2G, SOS1, MAGED1, IRAK4, MAP2K1, MAP3K5, MAPK8, AKT1, SHC1, PLCG1, NFKBIB, RPS6KA1, PRKCD, RPS6KA5, ARHGDIA, MAPK14, MAPKAPK2, MAPK3, RAF1, MAP2K2, AKT3, BAX, IKBKB, GSK3B, MAPK9, IRS2, AKT2, MAPK1, CRKL, PIK3CB, CSK, CAMK4, NGFR, PLCG2",0.562249437179612,0.206209615309181,FALSE
+"HCC827","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.32533,-0.987,0.369,8169,0.699,"NMNAT3, QPRT",0.43297363384094,0.155522824254319,FALSE
+"HCC827","Input","KEGG_NITROGEN_METABOLISM",-0.58679,-1.79,0.0276,7138,0.336,"CPS1, CA12, CA1, CA8, GLUD2, CA2",1.55909091793478,0.473660722610156,FALSE
+"HCC827","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.38359,-1.19,0.234,5818,0.595,"MAP3K7, RELA, BIRC2, TAB1, IKBKG, MAPK8, SUGT1, NFKBIB, CHUK, HSP90AB1, XIAP, MAPK14, MAPK3, IKBKB, TAB3, MAPK9, MAPK1, PYCARD",0.630784142589857,0.22548303427145,FALSE
+"HCC827","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.50889,-1.51,0.0877,6148,0.411,"LIG4, PRKDC, NHEJ1, XRCC6, XRCC5, FEN1",1.05700040663396,0.386158178123931,FALSE
+"HCC827","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.29756,0.849,0.659,338,0.858,"CDKN2A, EGFR, CDK4, TP53",0.18111458540599,0.0665127121512946,FALSE
+"HCC827","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.45648,1.28,0.176,1537,0.615,"DLL3, DTX3L, RBPJ, NUMB, ADAM17, MAML3, NCSTN, DTX2, NOTCH2, NOTCH3",0.75448733218585,0.211124884224583,FALSE
+"HCC827","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.29662,-0.868,0.557,5133,0.77,"PCNA, ERCC2, RAD23B, GTF2H5, RPA3, GTF2H2, CUL4B, GTF2H4, CETN2, CDK7, GTF2H1, ERCC1, ERCC6, CCNH, ERCC4, RAD23A, CUL4A, DDB2, XPC, XPA",0.254144804826271,0.113509274827518,FALSE
+"HCC827","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.24031,0.681,0.877,2078,0.979,"ST6GAL1, FUT8, DOLPP1, MAN1A2, B4GALT1, RPN2, DPM1, ALG6, STT3A, ALG13, MAN2A1",0.0570004066339595,0.00921730819686218,FALSE
+"HCC827","Input","KEGG_OLFACTORY_TRANSDUCTION",0.4055,1.15,0.268,2497,0.637,"CAMK2D, PDC, CAMK2B, PRKACA, CNGB1",0.571865205971211,0.19586056766465,FALSE
+"HCC827","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.42156,-1.22,0.221,7990,0.63,"DHFR, TYMS",0.655607726314889,0.200659450546418,FALSE
+"HCC827","Input","KEGG_OOCYTE_MEIOSIS",-0.36914,-1.06,0.364,5763,0.623,"SMC3, CDC26, SKP1, SMC1A, MAD2L1, ANAPC4, PRKACB, CCNB2, YWHAZ, PLK1, CAMK2G, PPP2R5C, PPP2R1B, ANAPC1, MAP2K1, PPP2R5A, SMC1B, CDC27, CDK1, ADCY5, PPP2CB, RPS6KA1, PPP2R5D, ADCY6, ITPR2, ANAPC7, PKMYT1, CUL1, MAPK3, CDC23, CDC16, ANAPC5, MAPK1, STAG3, ITPR1, CDK2, MAD2L2",0.438898616350944,0.20551195334083,FALSE
+"HCC827","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.60295,1.71,0.0457,1907,0.565,"FUCA1, AGA, FUCA2, MAN2B2, HEXB, HEXA, MANBA, GBA",1.34008379993015,0.247951552180562,FALSE
+"HCC827","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22541,0.65,0.911,2323,0.942,"COX6A1, PPA2, COX7A2, COX11, COX17, TCIRG1, COX7C, ATP5PF, COX5B, COX5A, UQCRH, COX6B1, NDUFB1, COX6C, LHPP, COX7A2L, ATP5MC2, COX4I1, NDUFB10, SDHC, UQCRFS1, COX7B, UQCRB, SDHA, SDHB, ATP6V1C1, ATP6AP1, UQCRC2, UQCRC1",0.0404816230270017,0.0259490972071227,FALSE
+"HCC827","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.62067,1.74,0.035,1051,0.83,"GALNT4, GALNT8, GALNT13, GALNT7, GALNT5, GALNT3, GALNT6, GALNT15, GALNT2, C1GALT1C1",1.45593195564972,0.0809219076239261,FALSE
+"HCC827","Input","KEGG_P53_SIGNALING_PATHWAY",0.26742,0.758,0.737,559,0.982,"CDKN2A, CDK4, TP53, TNFRSF10B, RCHY1",0.132532512140949,0.00788851221305034,FALSE
+"HCC827","Input","KEGG_PANCREATIC_CANCER",0.37719,1.08,0.33,751,0.66,"CDKN2A, EGFR, CDK4, RAC2, TGFBR2, TP53, STAT1, TGFB2, E2F3, RALB",0.481486060122112,0.180456064458131,FALSE
+"HCC827","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.5803,-1.69,0.0461,6522,0.317,"PPCDC, COASY, ENPP1, PANK4, PANK1",1.33629907461035,0.498940737782249,FALSE
+"HCC827","Input","KEGG_PARKINSONS_DISEASE",0.175,0.503,0.987,1852,0.992,"UBE2L6, UBA7, COX6A1, COX7A2, COX7C, ATP5PF, COX5B, COX5A, UQCRH, COX6B1, NDUFB1, COX6C, HTRA2, COX7A2L, ATP5MC2, COX4I1, NDUFB10, SDHC, SLC25A5, SLC25A31, UQCRFS1",0.00568284733036327,0.00348832784582135,FALSE
+"HCC827","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.3019,-0.901,0.548,6006,0.761,"NCK2, ARPC4, YWHAZ, ROCK2, ARPC1B, EZR, NCK1, ACTB, ARPC3, ARPC2, ROCK1, ARPC5, TUBA1B, TUBB1, TUBA3C, TUBB, ACTG1, CD14, TUBB2A, TUBB6, WAS, TUBAL3, ARHGEF2, HCLS1, TUBB2B",0.261219441515631,0.118615343229427,FALSE
+"HCC827","Input","KEGG_PATHWAYS_IN_CANCER",0.33588,0.971,0.465,751,0.78,"PTGS2, CDKN2A, EGFR, PML, CDH1, CDK4, LAMB3, ITGA3, ITGA2, ETS1, LAMC2, CTNNB1, ITGB1, RAC2, TGFBR2, TP53, CTNNA1, JUN, CTNNA2, STAT1, MET, ITGAV, TGFB2, E2F3, LAMB1, RALB",0.332547047110046,0.10790539730952,FALSE
+"HCC827","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.50903,-1.56,0.0649,7333,0.39,"CRYL1, DCXR, AKR1B1",1.18775530319963,0.408935392973501,FALSE
+"HCC827","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.56712,-1.7,0.0375,6180,0.329,"ALDOA, PGM2, ALDOC, PGLS, GPI, PFKL, PRPS1, PRPS1L1, PRPS2, PFKM, PGD, PFKP, TALDO1",1.42596873227228,0.482804102050026,FALSE
+"HCC827","Input","KEGG_PEROXISOME",0.39293,1.13,0.298,1309,0.659,"SOD2, ACSL4, ACOT8, SCP2, HMGCL, DHRS4, NUDT12, EPHX2, PIPOX, PEX13, SLC27A2, ACOX3, PAOX, HACL1, PECR, ABCD3, ACAA1, PEX3, ECH1",0.525783735923745,0.18111458540599,FALSE
+"HCC827","Input","KEGG_PHENYLALANINE_METABOLISM",-0.5462,-1.68,0.0447,7974,0.288,"ALDH3A1, MAOA, MAOB",1.34969247686806,0.540607512240769,FALSE
+"HCC827","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.36504,-1.06,0.326,6827,0.623,"SYNJ1, PLCG1, INPP5A, ITPR2, PIP5K1C, DGKH, CDIPT, PLCD3, PIP5K1A, OCRL, IMPA2, ITPKB, ITPR1, DGKQ, PIK3CB, ITPK1, PLCG2, ITPKA",0.486782399932061,0.20551195334083,FALSE
+"HCC827","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.36031,1.03,0.389,1755,0.701,"CP, ALAD, HMOX2, FTH1, ALAS1, HCCS",0.410050398674292,0.154281982033341,FALSE
+"HCC827","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.33219,-0.969,0.437,7762,0.709,"ME1, FABP7, FADS2, SORBS1, GK, CPT1A, CYP27A1, EHHADH",0.359518563029578,0.149353764816933,FALSE
+"HCC827","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.60303,-1.86,0.0325,7800,0.388,"AKR1D1, CYP27A1",1.48811663902113,0.411168274405793,FALSE
+"HCC827","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.54231,-1.62,0.0703,6426,0.336,"IKBKG, RFX5, JAK3, BLNK, ZAP70, CD40",1.15304467498018,0.473660722610156,FALSE
+"HCC827","Input","KEGG_PRION_DISEASES",-0.59536,-1.82,0.0236,7092,0.392,"NOTCH1, MAPK3, MAP2K2, BAX, SOD1, MAPK1, C9, NCAM1",1.62708799702989,0.406713932979543,FALSE
+"HCC827","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.35668,-1.06,0.338,6539,0.623,"ANAPC1, MAP2K1, MAPK8, AKT1, CDC27, CDK1, ADCY5, RPS6KA1, ADCY6, ANAPC7, HSP90AB1, PKMYT1, MAPK14, MAPK3, CDC23, RAF1, AKT3, MAPK9, CDC16, ANAPC5, AKT2, MAPK1, CDK2, PIK3CB, MAD2L2",0.471083299722345,0.20551195334083,FALSE
+"HCC827","Input","KEGG_PROPANOATE_METABOLISM",-0.36247,-1.06,0.354,7705,0.623,"ACAT2, ACSS2, ACSS1, ACSS3, EHHADH",0.450996737974212,0.20551195334083,FALSE
+"HCC827","Input","KEGG_PROSTATE_CANCER",-0.26497,-0.787,0.694,6273,0.813,"SOS1, CCND1, IKBKG, MAP2K1, MTOR, AKT1, CHUK, RB1, HSP90AB1, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, TCF7L1, AKT2, CASP9, MAPK1, CDK2, PIK3CB, FGFR1",0.158640529545145,0.0899094544059319,FALSE
+"HCC827","Input","KEGG_PROTEASOME",0.36334,1.05,0.374,474,0.689,"PSMB10, PSMB9, PSMB8",0.42712839779952,0.161780778092374,FALSE
+"HCC827","Input","KEGG_PROTEIN_EXPORT",0.19957,0.579,0.973,1782,0.977,"OXA1L, SRPRA, HSPA5, SRPRB",0.0118871597316481,0.0101054362812269,FALSE
+"HCC827","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.59592,-1.75,0.0408,7909,0.325,"ATP1B3, GLUD2, CA2",1.38933983691012,0.488116639021126,FALSE
+"HCC827","Input","KEGG_PURINE_METABOLISM",-0.35688,-1.07,0.327,6266,0.657,"PRIM1, NT5C2, POLR3D, ADSL, PAPSS1, NT5C, AMPD3, PRIM2, PRPS1, PRPS1L1, ADCY5, PKLR, AMPD2, POLR3C, PRPS2, ADCY6, PAICS, NME7, GMPS, PPAT, ENPP1, DCK, AK5, IMPDH1, ENTPD4, NT5C3A, PKM, ENTPD8, GMPR, NUDT2, PDE4D, PDE8A, NME4, RRM2B, RRM2, NUDT5, RRM1, POLR2F",0.485452247339714,0.182434630440219,FALSE
+"HCC827","Input","KEGG_PYRIMIDINE_METABOLISM",-0.23456,-0.703,0.81,6831,0.89,"UMPS, POLR3C, NME7, DCK, CTPS2, ENTPD4, NT5C3A, ENTPD8, NUDT2, DUT, NME4, RRM2B, RRM2, UCK2, RRM1, TYMS, POLR2F",0.0915149811213502,0.0506099933550872,FALSE
+"HCC827","Input","KEGG_PYRUVATE_METABOLISM",-0.36411,-1.07,0.33,6232,0.657,"ACACA, MDH1, GRHPR, PC, ALDH7A1, ALDH2, PKLR, GLO1, PKM, ACYP2, HAGH, ACAT2, ACSS2, ME1, AKR1B1, ACSS1",0.481486060122112,0.182434630440219,FALSE
+"HCC827","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.32198,0.922,0.507,552,0.78,"ITGB6, PIP4K2C, ITGB2, EGFR, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, RAC2, GNG12, ITGAV, CFL2",0.294992040666664,0.10790539730952,FALSE
+"HCC827","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.24024,-0.715,0.828,5510,0.892,"PRKAA1, ATG3, ATG7, ATG4B",0.0819696632151199,0.0496351456238769,FALSE
+"HCC827","Input","KEGG_RENAL_CELL_CARCINOMA",-0.21373,-0.64,0.907,7197,0.954,"EGLN1, MAPK3, RAF1, MAP2K2, AKT3, AKT2, MAPK1, CRKL, PIK3CB",0.0423927129399047,0.0204516252959049,FALSE
+"HCC827","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.40697,-1.2,0.212,7860,0.612,"ANPEP, MME",0.673664139071249,0.213248577854439,FALSE
+"HCC827","Input","KEGG_RETINOL_METABOLISM",0.54332,1.55,0.07,1049,0.411,"RDH10, DHRS3, DHRS4, PNPLA4, RDH11",1.15490195998574,0.386158178123931,FALSE
+"HCC827","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.43527,-1.31,0.161,6704,0.513,"ACP2, ENPP1, MTMR6, TYR, MTMR2",0.79317412396815,0.289882634888184,FALSE
+"HCC827","Input","KEGG_RIBOSOME",-0.5251,-1.5,0.0964,5682,0.387,"RPS25, RPL21, RPL34, RPL32, RPS28, RPL5, RPL36, RPS2, RPL28, RPS7, RPS8, RPS6, RPL17, RPL7, RPL10, RPL15, RPL6, RPL26, RPL35A, RPL3, RPL23A, RPL10A, RPL12, RPL19, RPLP0, RPL13A, RPS10, UBA52, RPL4, RPS26, RPS17, RPL30, RPS15, RPL7A, RPS11, RPS3A, RPL31, RPS24, RPL18A, RPS19, RPL9, RPS15A, RPS13, RPS9, RPS5, RPS16, RPS3, RPL14, RPS4X, RPS27L, RPL22, RPL8, RPL27A, RPS20, RPL35, RPS18, RPL26L1",1.01592296609717,0.412289034981089,FALSE
+"HCC827","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.39221,-1.2,0.214,8272,0.612,"DDX3Y",0.669586226650809,0.213248577854439,FALSE
+"HCC827","Input","KEGG_RNA_DEGRADATION",-0.14669,-0.434,1,1866,0.999,"HSPD1, LSM6, LSM2, LSM3, LSM8, HSPA9, XRN2, CNOT2, LSM7, PATL1, EXOSC5, DCP1B, ENO1, DCP1A, EXOSC1, DCP2, EDC3, LSM4, EXOSC2, TTC37, MTREX, SKIV2L, WDR61, EXOSC4, CNOT3, EXOSC3, EDC4, EXOSC7, ENO3, EXOSC8, CNOT7, DIS3, PAPOLG, CNOT10, ENO2, MPHOSPH6, EXOSC9, C1D, PAPOLA, EXOSC6, ZCCHC7, EXOSC10, CNOT4, CNOT1, PARN, XRN1, DCPS, CNOT9, DDX6, LSM1",0,0.000434511774017692,FALSE
+"HCC827","Input","KEGG_RNA_POLYMERASE",-0.30648,-0.907,0.553,8204,0.784,"POLR2F",0.257274868695302,0.105683937315562,FALSE
+"HCC827","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.33493,-0.98,0.44,7042,0.701,"SEPHS2, MAT1A, AHCY, SEPHS1, METTL2B, BUD23, LCMT1",0.356547323513813,0.154281982033341,FALSE
+"HCC827","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.43864,1.25,0.189,1123,0.603,"PTGS2, CDK4, LAMB3, ITGA3, ITGA2, LAMC2, ITGB1, TP53, ITGAV, E2F3, LAMB1, ITGA6, MAX, LAMA5, PIK3R3",0.723538195826756,0.219682687859849,FALSE
+"HCC827","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.41152,1.16,0.277,2182,0.656,"STX17, VAMP8, STX18, STX3, STX6, BNIP1, STX8, STX12, GOSR1, VTI1B, SEC22B, SNAP47, STX7",0.557520230935551,0.18309616062434,FALSE
+"HCC827","Input","KEGG_SPHINGOLIPID_METABOLISM",0.49217,1.4,0.123,2056,0.465,"PLPP2, PLPP1, UGT8, GLA, GALC, ASAH1, PLPP3, SPHK2, GBA, SMPD1, SPTLC1",0.910094888560602,0.332547047110046,FALSE
+"HCC827","Input","KEGG_SPLICEOSOME",0.27832,0.789,0.706,3534,0.936,"HNRNPA1, SRSF7, SNRNP27, ACIN1, HNRNPM, SF3B5, PRPF40A, NCBP2, ZMAT2, HNRNPU, SART1, PRPF19, PRPF4, WBP11, SRSF5, TRA2A, SNRNP40, DHX38, CWC15, LSM6, SRSF6, LSM2, LSM3, U2AF2, CDC5L, U2AF1, SNRPF, SNRPG, SNRNP70, HNRNPA3, SRSF10, LSM8, BCAS2, SNRPB, RBM25, PRPF31, PRPF38B, SF3B6, SF3A1, PRPF38A, HSPA6, SRSF9, HNRNPC, SNRPC, TRA2B, SF3B2, SF3B3, HNRNPK, LSM7, PQBP1, DDX5, SNW1, SNRPA, TCERG1, DDX23, PUF60, SLU7, XAB2, PLRG1, EFTUD2, SRSF3, SF3A2, DDX39B, SNU13, SRSF1, SNRPD3, TXNL4A, RBM8A, PPIL1, PPIH, PHF5A, SF3A3",0.151195298948196,0.0287241512618947,FALSE
+"HCC827","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.33452,0.939,0.498,846,0.803,"PGM2L1, GAA, UGDH, UXS1, PYGL",0.302770657240282,0.095284454721319,FALSE
+"HCC827","Input","KEGG_STEROID_BIOSYNTHESIS",-0.36869,-1.1,0.319,6533,0.642,"CYP51A1, LSS, CEL, LIPA, MSMO1, SOAT2, SQLE",0.496209316942819,0.192464971931147,FALSE
+"HCC827","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.46991,-1.39,0.13,6750,0.446,"SRD5A1, CYP21A2, COMT, HSD17B2, SULT2B1, AKR1C3, AKR1D1, AKR1C1",0.886056647693163,0.350665141287858,FALSE
+"HCC827","Input","KEGG_SULFUR_METABOLISM",-0.55821,-1.68,0.0422,7685,0.288,"SULT2B1, SULT1A1, CHST12",1.37468754903833,0.540607512240769,FALSE
+"HCC827","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.51444,-1.5,0.0913,6007,0.387,"ACTN4, ACTN1, ACTN2, C4A, C9, CD40",1.0395292224657,0.412289034981089,FALSE
+"HCC827","Input","KEGG_TASTE_TRANSDUCTION",0.48765,1.4,0.116,2777,0.465,"SCNN1A, GNB3, ITPR3, GNB1, PRKACA, KCNB1, CACNA1A",0.935542010773082,0.332547047110046,FALSE
+"HCC827","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.64977,-1.96,0.016,6772,1,"GGPS1, MVK, ACAT2, PMVK, HMGCS1, FDPS, IDI1",1.79588001734408,0,FALSE
+"HCC827","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.31245,-0.926,0.461,6369,0.759,"PPP2R1B, RPS6KB2, SMAD1, SMAD4, ROCK1, SMAD5, PPP2CB, SMAD2, SMAD9, CUL1, MAPK3, INHBE, RPS6KB1, THBS2, MAPK1, ID1",0.336299074610352,0.11975822410452,FALSE
+"HCC827","Input","KEGG_THYROID_CANCER",0.40571,1.17,0.244,338,0.656,"CDH1, CTNNB1, TP53",0.612610173661271,0.18309616062434,FALSE
+"HCC827","Input","KEGG_TIGHT_JUNCTION",0.45473,1.27,0.188,1351,0.61,"CDK4, OCLN, EPB41L1, CLDN6, RAB3B, CLDN3, CLDN4, CTNNB1, CGN, F11R, TJP2, CTNNA1, CTNNA2, TJP3, TJP1, MPDZ, AFDN, PATJ, LLGL1, GNAI1, GNAI3, CASK, EXOC4, CLDN1, PARD3, PRKCB, SRC",0.72584215073632,0.214670164989233,FALSE
+"HCC827","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.32552,-0.957,0.428,6198,0.721,"TAB1, IRF3, RIPK1, IKBKG, IRAK4, TRAF3, MAP2K1, MAPK8, AKT1, CHUK, MAPK14, MAPK3, IFNAR1, CD14, MAP2K2, AKT3, IKBKB, MAPK9, AKT2, MAPK1, PIK3CB, LBP, CD40",0.368556230986828,0.142064735280571,FALSE
+"HCC827","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.47167,-1.42,0.116,7705,0.421,"ACAT2, AADAT, MAOA, MAOB, EHHADH",0.935542010773082,0.375717904164332,FALSE
+"HCC827","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.63282,-1.88,0.031,6598,0.432,"MTOR, MAPK8, PKLR, PRKCD, MAPK3, PKM, IKBKB, MAPK9, IRS2, MAPK1, PIK3CB, HK3, GCK",1.50863830616573,0.364516253185088,FALSE
+"HCC827","Input","KEGG_TYROSINE_METABOLISM",-0.59036,-1.76,0.0353,7770,0.342,"TYR, METTL2B, DCT, ALDH3A1, BUD23, LCMT1, MAOA, MAOB",1.45222529461218,0.465973893943865,FALSE
+"HCC827","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.29288,-0.87,0.583,6273,0.778,"SOS1, NCK1, PRKCQ, IKBKG, MAP2K1, NFAT5, CBL, AKT1, PLCG1, NFKBIB, CHUK, MAPK14, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, MAPK9, AKT2, MAPK1, PIK3CB, ZAP70",0.234331445240986,0.109020403010311,FALSE
+"HCC827","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.30347,-0.883,0.513,6766,0.786,"CDC27, FANCL, CUL7, HUWE1, UBE2F, UBE2E1, CDC34, CUL4A, ANAPC7, SAE1, MID1, DDB2, CUL1, UBE2Q1, PIAS1, PPIL2, XIAP, UBA1, UBE2E3, UBE2G2, CDC23, PIAS4, UBE2S, UBE2B, FBXW7, UBE3A, HERC1, PIAS2, RNF7, CDC16, UBE2L3, ANAPC5, UBA2, UBE2M, HERC4, FBXO2",0.289882634888184,0.104577453960592,FALSE
+"HCC827","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.29309,0.84,0.655,2807,0.862,"PDHB, PDHA1, IARS2",0.183758700008217,0.0644927341752872,FALSE
+"HCC827","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37663,1.08,0.314,1450,0.66,"ACADS, IVD, HMGCL, ACAD8, DBT, ALDH1B1, MCCC1, AUH, ACAA1, HIBCH, HIBADH, MCCC2, ACADM, ALDH6A1",0.503070351926785,0.180456064458131,FALSE
+"HCC827","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.29063,-0.845,0.587,6004,0.774,"ACTA2, PRKACB, PLCB1, ROCK2, MYH11, PRKCQ, MAP2K1, ROCK1, ADCY5, ADCY6, ITPR2, PRKCD, MAPK3, RAF1, MAP2K2, MAPK1, ITPR1, ARHGEF1, ARHGEF11, KCNMA1",0.231361898752386,0.111259039317107,FALSE
+"HCC827","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33272,0.941,0.498,2090,0.815,"ARHGDIB, RAB11A, CREB1, RAB11B, DYNC1LI2, RAB5B, DYNLL2, ADCY9, RAB5A, CREB5, RAB5C",0.302770657240282,0.0888423912600234,FALSE
+"HCC827","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.28054,-0.855,0.602,7259,0.786,"MAPK14, MAPKAPK2, MAPK3, RAF1, MAP2K2, AKT3, AKT2, CASP9, MAPK1, PIK3CB, PLCG2",0.220403508742175,0.104577453960592,FALSE
+"HCC827","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.20452,0.582,0.972,1059,0.988,"ERO1A, TJP2, TCIRG1, TJP1, SLC12A2, PDIA4",0.0123337350737254,0.00524305541237188,FALSE
+"HCC827","Input","KEGG_VIRAL_MYOCARDITIS",0.32775,0.927,0.52,255,0.784,"ITGB2, CXADR, ICAM1, RAC2",0.283996656365201,0.105683937315562,FALSE
+"HCC827","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31177,0.898,0.571,678,0.817,"CTNNB1, LRP5, PLCB4, RAC2, TP53, JUN, CAMK2D, DAAM1, DAAM2, CHD8",0.243363891754152,0.0877779434675845,FALSE
+"HCC95","Input","KEGG_ABC_TRANSPORTERS",0.39284,1.15,0.275,1732,0.659,"ABCC5, ABCC8, ABCC3, ABCC1, ABCC4, TAP1, ABCB10, TAP2, ABCB6, ABCC2",0.560667306169737,0.18111458540599,FALSE
+"HCC95","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.28754,0.841,0.635,1460,0.785,"PML, IKBKB, KRAS, NRAS, RARA, HRAS, BAD, MYC, EIF4EBP1, STAT3",0.197226274708024,0.105130343254747,FALSE
+"HCC95","Input","KEGG_ADHERENS_JUNCTION",0.34188,1.01,0.403,1106,0.724,"NECTIN1, EGFR, YES1, IGF1R, PTPN6, RAC2, SMAD3, RAC3, SRC, CTNND1, ACTN4, MET",0.39469495385889,0.140261433802853,FALSE
+"HCC95","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.29338,0.882,0.559,822,0.818,"SLC2A1, RXRA, IKBKB, IRS1, PCK2",0.252588192113577,0.087246696328677,FALSE
+"HCC95","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32401,-0.938,0.502,7877,0.831,"CPS1, GPT, GLS, GLS2, GLUD2",0.299296282854981,0.080398976215889,FALSE
+"HCC95","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.28782,0.859,0.593,1227,0.786,"ATP1B3, IRS1, KRAS, ATP1A3, ATP1B1, ATP1A1, ATP1A4, SFN",0.226945306635737,0.104577453960592,FALSE
+"HCC95","Input","KEGG_ALZHEIMERS_DISEASE",-0.32101,-0.914,0.514,6408,0.856,"FADD, COX7A2, COX4I1, NDUFS2, UQCRQ, NDUFA3, LPL, GSK3B, NDUFAB1, APH1A, NCSTN, CASP3, COX5A, NDUFB4, PPP3CC, MME, MAPK1, NDUFB7, COX6C, NDUFA2, EIF2AK3, MAPK3, COX7C, CAPN2, HSD17B10, CYCS, CALM2, PPP3R1, PPP3R2, PSEN2, COX7B, APOE, PSEN1, BACE2, ATP5MC2",0.289036881004724,0.0675262353228468,FALSE
+"HCC95","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.34247,-1.02,0.378,5695,0.786,"PARS2, FARSB, TARS2, AARS2, LARS2, FARS2, YARS2, FARSA, EARS2, MARS2, CARS2",0.422508200162775,0.104577453960592,FALSE
+"HCC95","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.40248,-1.16,0.248,6876,0.717,"UGP2, GMPPB, GALK1, CYB5R3, GALK2, GNPNAT1, PMM2, GMDS, AMDHD2, RENBP, NAGK, GALT, GNE, GCK, PGM1, UAP1",0.605548319173784,0.1444808443322,FALSE
+"HCC95","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.32409,-0.945,0.467,7912,0.845,"NEFL, RAB5A, TOMM40L, MAP3K5, CYCS, PPP3R1, PPP3R2, NEFH, PRPH, PRPH2",0.330683119433888,0.0731432910503077,FALSE
+"HCC95","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.38863,1.14,0.265,2128,0.64,"CTSB, TAPBP, B2M, NFYB, HSPA5, NFYA, TAP1, PSME1, TAP2, PSME2, HSPA1A, CANX, CTSL, NFYC, HSPA6, PSME3",0.576754126063192,0.193820026016113,FALSE
+"HCC95","Input","KEGG_APOPTOSIS",-0.30823,-0.904,0.518,7082,0.837,"CASP3, AKT3, PPP3CC, IRAK4, CASP6, PRKACA, PRKAR2B, AIFM1, AKT1, EXOG, MYD88, CAPN2, PIK3CB, CYCS, PPP3R1, PPP3R2, PRKACB, RIPK1",0.285670240254767,0.07727454200674,FALSE
+"HCC95","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.43307,1.3,0.16,1264,0.578,"AKR1C3, CYP4F3, CBR1, EPHX2, GPX2, PTGS2, ALOX5, CBR3, PTGES2",0.795880017344075,0.238072161579471,FALSE
+"HCC95","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34959,1.05,0.362,1592,0.72,"CKMT1A, CKMT2, ODC1, ASS1, PYCR2, SAT2, GATM, PYCR1, ARG1, P4HA2, OTC, ALDH4A1, GOT2, ALDH2, MAOA, GLUL, SAT1, PRODH, PRODH2, ALDH3A2",0.441291429466834,0.142667503568732,FALSE
+"HCC95","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.31875,0.925,0.494,622,0.783,"ITGB4, GJA1, ITGA2, ITGA6, ITGA5, ITGA3, CDH2, ITGB8",0.306273051076353,0.106238237942057,FALSE
+"HCC95","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.69405,-2.05,0.00929,8524,0.235,"ALDH9A1, ALDH7A1",2.03198428600636,0.628932137728264,TRUE
+"HCC95","Input","KEGG_AXON_GUIDANCE",0.36922,1.09,0.301,1256,0.689,"EFNA5, EFNB1, UNC5B, SEMA4D, SEMA4B, SEMA5B, PLXNB2, EFNB2, EPHA2, ROBO2, RAC2, NTN4, EFNB3, PLXNA2, EPHB3, KRAS, NRAS, RAC3, SEMA3C, NCK1, HRAS, MET, EPHA6, SLIT1, SLIT3, NTN1",0.521433504406157,0.161780778092374,FALSE
+"HCC95","Input","KEGG_BASAL_CELL_CARCINOMA",0.50903,1.51,0.0805,1596,0.365,"FZD1, WNT5A, FZD6, FZD2, DVL3, TP53",1.09420411963213,0.437707135543525,FALSE
+"HCC95","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.50586,1.5,0.0789,2318,0.36,"TAF7, TAF1, GTF2A2, TAF2, GTF2F2, GTF2B, GTF2H1, GTF2H4, GTF2H3, TAF9, TAF6, TBPL1",1.10292299679058,0.443697499232713,FALSE
+"HCC95","Input","KEGG_BASE_EXCISION_REPAIR",0.51717,1.53,0.0847,3256,0.359,"POLB, PARP2, POLD3, APEX1, POLD4, POLE, POLD1, LIG3, TDG, POLE4, POLD2, HMGB1, PARP1, XRCC1, POLE3, FEN1, MPG, MBD4, PCNA",1.07211658966929,0.444905551421681,FALSE
+"HCC95","Input","KEGG_BETA_ALANINE_METABOLISM",-0.6157,-1.73,0.0406,8121,0.266,"SRM, SMS, ALDH9A1, ALDH7A1",1.39147396642281,0.575118363368933,FALSE
+"HCC95","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.54086,-1.59,0.0621,7833,0.275,"ACOT7, ACOT2, PECR, ACOX3, YOD1, ACAA1, ACOT1, ACOT4",1.20690839982342,0.560667306169737,FALSE
+"HCC95","Input","KEGG_BLADDER_CANCER",0.43275,1.27,0.183,1129,0.588,"EGFR, KRAS, NRAS, THBS1, RPS6KA5, RB1, HRAS, MYC",0.737548910269571,0.230622673923862,FALSE
+"HCC95","Input","KEGG_BUTANOATE_METABOLISM",-0.33985,-0.984,0.42,7232,0.804,"AACS, PDHA1, PDHB, BDH2, ACAT1, ALDH9A1, ALDH7A1",0.3767507096021,0.0947439512515487,FALSE
+"HCC95","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.25152,-0.747,0.775,6772,0.895,"NFKBIB, GSK3B, AKT2, NFAT5, AKT3, CD81, PPP3CC, MAPK1, PIK3AP1, MAPK3, SOS1, AKT1, INPP5D, PIK3CB, PPP3R1, PPP3R2, PRKCB, NFATC2",0.11069829749369,0.048176964684088,FALSE
+"HCC95","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.29773,-0.872,0.605,8274,0.853,"MYLK, CALM2, PPP3R1, ERBB3, PPP3R2, PRKACB, PRKCB, SPHK2, CACNA1A, BST1, PDE1C",0.218244625347531,0.069050968832477,FALSE
+"HCC95","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.27473,-0.816,0.659,6417,0.857,"COX7A2, COX4I1, CACNB2, UQCRQ, TPM4, TPM1, SLC8A1, COX5A, COX6C, MYL3, SLC9A6, CACNA2D1, COX7C, TPM3, TPM2, COX7B",0.18111458540599,0.0670191780768018,FALSE
+"HCC95","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.50287,1.48,0.0902,444,0.349,"NECTIN1, CLDN11, SDC1, JAM3, CDH4, CNTN1, CLDN6, CD40, ITGA6, CD274, CLDN1, CNTNAP1, CDH2, ALCAM, CDH15, CDH3",1.04479346245806,0.45717457304082,FALSE
+"HCC95","Input","KEGG_CELL_CYCLE",0.2799,0.82,0.67,2343,0.801,"TGFB2, CDC23, SMAD3, ANAPC4, CDC16, ANAPC7, ANAPC5, RBL1, CDC26, RB1, ORC3, CDC27, MYC, SFN, TFDP2, CDKN1B, CDK7, ANAPC1, ATM, SMC1B, TP53, BUB3, CCNB1, BUB1B, ORC4, MAD1L1, YWHAG, MCM5, MCM4, MCM3, RAD21, RBX1, CUL1, PRKDC, FZR1, SMC3, MCM6",0.173925197299174,0.0963674839157623,FALSE
+"HCC95","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.22284,-0.643,0.922,6849,1,"GSK3B, AKT2, GNB1, GSK3A, CXCL14, AKT3, ROCK1, ROCK2, RAP1A, MAPK1, PRKACA, GRK2, CCL13, GNG7, RAP1B, MAPK3, ARRB2, ADCY5, SOS1, AKT1, STAT2, CCL15, TIAM1, CSK, PIK3CB, PRKACB, ARRB1, ADCY6, PRKCB",0.0352690789463706,0,FALSE
+"HCC95","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.19649,0.59,0.981,1405,0.973,"IKBKB, TGFB2, SMAD3, KRAS, NRAS, RB1, HRAS, BAD, GAB2, MYC, BCL2L1, CDKN1B",0.0083309926200515,0.0118871597316481,FALSE
+"HCC95","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.20983,-0.615,0.925,5925,1,"ACO1, DLD, IDH1, IDH3G, MDH1, CS, SUCLG1, PDHA1, PDHB, SUCLG2, IDH2",0.0338582672609674,0,FALSE
+"HCC95","Input","KEGG_COLORECTAL_CANCER",-0.20102,-0.59,0.935,6480,0.983,"CCND1, PIK3R1, BAX, CTNNB1, GSK3B, AKT2, CASP3, APPL1, AKT3, MAPK1, MAPK3, AKT1, TGFB3, PIK3CB, CYCS, SMAD2",0.0291883891274822,0.00744648216786438,FALSE
+"HCC95","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.56546,1.68,0.0474,795,0.294,"C9, PLAU, PLAT, F3, C3, VWF, CFH, MBL2",1.32422165832591,0.531652669587843,FALSE
+"HCC95","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.29591,-0.864,0.575,7600,0.858,"DNMT1, MTR, LDHA, SRM, SMS, ADI1, AMD1",0.24033215531037,0.0665127121512946,FALSE
+"HCC95","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.55509,1.65,0.0553,611,0.302,"EGFR, NGFR, IFNGR1, IL1RAP, CD40, IL1R2, LTBR, ACVR1, TGFB2, IL18, PLEKHO2, CXCL6",1.2572748686953,0.519993057042849,FALSE
+"HCC95","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.35365,1.02,0.388,905,0.734,"ZBP1, CASP1, IKBKB, IL18, MAVS",0.411168274405793,0.134303940083929,FALSE
+"HCC95","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.3576,-1.06,0.331,7283,0.801,"SGCD, DMD, PRKACA, MYL3, ITGB1, ACTG1, ADCY5, CACNA2D1, TPM3, TGFB3, TPM2, ITGA1, ITGA7, PRKACB, ADCY6, ITGA4, ITGB5, DES, ITGB3",0.480172006224281,0.0963674839157623,FALSE
+"HCC95","Input","KEGG_DNA_REPLICATION",0.42673,1.29,0.168,2505,0.573,"RFC2, SSBP1, POLD3, RFC4, RFC5, POLD4, RNASEH2A, POLE, POLD1, RPA3, MCM5, RPA2, MCM4, MCM3, POLE4, POLD2, MCM6, RPA1",0.774690718274137,0.24184537803261,FALSE
+"HCC95","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.38939,1.14,0.268,1183,0.64,"EGFR, KRAS, ETV6",0.571865205971211,0.193820026016113,FALSE
+"HCC95","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.59062,1.73,0.0385,162,0.29,"ADH4, ADH7, ALDH3A1, GSTM3",1.4145392704915,0.537602002101044,FALSE
+"HCC95","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.34528,1.02,0.392,2331,0.734,"CES1, CES2, GMPS, TPMT, IMPDH1, NAT2, NAT1, XDH, IMPDH2, HPRT1, UCKL1, GUSB",0.406713932979543,0.134303940083929,FALSE
+"HCC95","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.40015,1.2,0.233,741,0.596,"CD44, SDC1, ITGB4, LAMA1, ITGA2, ITGA6, LAMB3, TNC, ITGA5, ITGA3, LAMC2, VWF, ITGB8, LAMA5, THBS1",0.632644078973981,0.224753740259764,FALSE
+"HCC95","Input","KEGG_ENDOCYTOSIS",-0.2701,-0.79,0.699,7143,0.872,"RABEP1, SH3GLB1, DNM1L, ASAP1, CBLB, VPS4A, EHD1, NEDD4L, CHMP2B, GRK2, PLD1, STAM, VPS37A, DNM2, MVB12B, PIP4K2B, RAB5B, SMAP2, ARRB2, SH3GL1, RAB5A, HSPA1L, RAB11B, ASAP2, RAB11FIP5, HSPA2, IQSEC1, PARD6B, ACAP1, DAB2, ERBB3, WWP1, PARD6G, ITCH, ARRB1, DNAJC6, SH3KBP1",0.155522824254319,0.0594835150674328,FALSE
+"HCC95","Input","KEGG_ENDOMETRIAL_CANCER",0.27796,0.83,0.661,1596,0.794,"EGFR, KRAS, NRAS, HRAS, BAD, MYC, MLH1, FOXO3, TP53",0.17979854051436,0.100179497572904,FALSE
+"HCC95","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.39358,1.16,0.261,1106,0.659,"EGFR, PTPRZ1, JAM3, IKBKB, LYN, ADAM17, JUN, MAPK12, SRC, F11R, MET",0.583359492661719,0.18111458540599,FALSE
+"HCC95","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.2687,0.784,0.737,1129,0.821,"NRG1, EGFR, JUN, KRAS, NRAS, NCK1, SRC, HRAS, BAD, MYC",0.132532512140949,0.0856568428805592,FALSE
+"HCC95","Input","KEGG_ETHER_LIPID_METABOLISM",-0.4131,-1.21,0.224,7460,0.699,"PLD1, AGPS, PAFAH1B3, PAFAH2, PLA2G12A",0.649751981665837,0.155522824254319,FALSE
+"HCC95","Input","KEGG_FATTY_ACID_METABOLISM",0.32621,0.964,0.476,4,0.759,"ADH4, ADH7",0.322393047279507,0.11975822410452,FALSE
+"HCC95","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.22993,-0.673,0.882,6376,0.989,"VAV2, MAP2K2, PIK3R1, MAP2K3, MAP2K4, AKT2, AKT3, PRKCE, MAPK14, MAPK1, PRKCA, PLCG1, MAPK3, SOS1, MAP2K7, AKT1, INPP5D, PIK3CB, PLA2G12A, PRKCB",0.0545314148681803,0.0048037084028206,FALSE
+"HCC95","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.45128,-1.31,0.156,7113,0.562,"ARPC3, AKT3, DNM1L, PRKCE, ASAP1, MAPK1, PRKCA, PLD1, WASF2, DNM2, PIP4K2B, PLCG1, MAPK3, GSN, AKT1, MARCKS, PRKCG, VASP, INPP5D, ASAP2, PIK3CB, SCIN, PRKCB, SPHK2, CFL2, PTPRC, AMPH, MARCKSL1",0.806875401645538,0.250263684430939,FALSE
+"HCC95","Input","KEGG_FOCAL_ADHESION",0.30851,0.945,0.48,823,0.769,"EGFR, CAV1, CAV2, ITGB4, LAMA1, ITGA2, ITGA6, LAMB3, VAV1, TNC, ITGA5, ITGA3, IGF1R, LAMC2, RAC2, VWF, JUN, ITGB8, LAMA5, RAC3, THBS1, SRC",0.318758762624413,0.114073660198569,FALSE
+"HCC95","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.6915,-2.02,0.00568,6964,0.206,"GGH, PTS, ALPI, ALPP, ALPL",2.24565166428898,0.686132779630847,TRUE
+"HCC95","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.31105,0.909,0.521,267,0.802,"AKR1B10, ALDOC, AKR1B1",0.283162276700476,0.0958256317158365,FALSE
+"HCC95","Input","KEGG_GALACTOSE_METABOLISM",-0.3265,-0.954,0.465,6547,0.857,"HK2, GALE, GLB1, UGP2, GALK1, PFKL, GALK2, PFKP, GALT, GCK, PGM1",0.332547047110046,0.0670191780768018,FALSE
+"HCC95","Input","KEGG_GAP_JUNCTION",0.24179,0.716,0.825,1246,0.891,"EGFR, GJA1, KRAS, NRAS, SRC, PLCB4, ADCY3, ADCY8, HRAS, MAP3K2, TUBA4A",0.0835460514500749,0.0501222959631252,FALSE
+"HCC95","Input","KEGG_GLIOMA",-0.26594,-0.782,0.703,7341,0.876,"MAPK1, PRKCA, PLCG1, MAPK3, SOS1, AKT1, PRKCG, CDK6, PIK3CB, CALM2, PRKCB, CDKN2A",0.153044674980176,0.0574958938319193,FALSE
+"HCC95","Input","KEGG_GLUTATHIONE_METABOLISM",0.34949,1.01,0.383,897,0.724,"GCLC, GCLM, GSTM3, ODC1, PGD, GPX2, GSS, GSTP1, GSR, G6PD",0.416801226031377,0.140261433802853,FALSE
+"HCC95","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.54756,-1.64,0.0487,8387,0.252,"CEL, GK, ALDH9A1, ALDH7A1, MGLL",1.31247103878537,0.598599459218456,FALSE
+"HCC95","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33046,0.964,0.454,1358,0.759,"LPCAT3, PCYT1B, PCYT1A, PLPP1, DGKA, LCLAT1, DGKZ, LPCAT2, CDIPT, PISD",0.342944147142896,0.11975822410452,FALSE
+"HCC95","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.40043,1.2,0.247,1202,0.596,"PIPOX, GATM, PHGDH, PSAT1, MAOA, PSPH",0.607303046740334,0.224753740259764,FALSE
+"HCC95","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.36729,1.08,0.339,175,0.675,"ADH4, ADH7, ALDH3A1, ALDOC",0.469800301796918,0.170696227168975,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.41301,1.21,0.231,1065,0.639,"XYLT2, CHST14, B4GALT7",0.636388020107856,0.1944991418416,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.57653,1.74,0.0273,1478,0.31,"HS6ST2, XYLT2, B4GALT7, EXTL2",1.56383735295924,0.508638306165727,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.55906,-1.64,0.0592,6606,0.252,"FUT8, B4GALT3, B4GAT1, B4GALT4, ST3GAL2",1.22767829327708,0.598599459218456,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.27533,0.801,0.684,3109,0.813,"IDS, HPSE, HEXB, ARSB, GUSB, SGSH, HEXA",0.164943898279884,0.0899094544059319,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.26283,-0.779,0.755,8275,0.87,"ST3GAL2",0.122053048370812,0.0604807473813815,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.41618,1.23,0.195,1786,0.622,"GLA, FUT1, HEXB",0.709965388637482,0.206209615309181,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.59234,-1.7,0.0471,8249,0.257,"B4GALT4, GCNT2, ST3GAL6, ST3GAL4, B3GNT3",1.3269790928711,0.590066876668705,FALSE
+"HCC95","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.29889,0.864,0.559,6214,0.801,"PIGB, PIGS, PIGX, PGAP1, PIGU, PIGT, PIGO, PIGG, GPAA1, PIGK, PIGW, PIGA",0.252588192113577,0.0963674839157623,FALSE
+"HCC95","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.55036,-1.66,0.0375,6527,0.28,"MDH1, CS, PGP, HYI",1.42596873227228,0.552841968657781,FALSE
+"HCC95","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.27382,0.816,0.719,1177,0.797,"EGFR, MMP14, JUN, MAPK12, KRAS, NRAS, SRC, PLCB4, ADCY3, ADCY8, ATF4, HRAS, MAP3K2, CALML3",0.143271109617117,0.0985416786038876,FALSE
+"HCC95","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.29688,-0.861,0.601,6745,0.85,"WNT11, GSK3B, PRKACA, CSNK1G2, SHH, CSNK1D, PRKACB",0.22112552799726,0.0705810742857073,FALSE
+"HCC95","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.52269,1.54,0.0737,442,0.368,"CD44, ITGA2, ITGA6, IL1R2, ITGA5, ITGA3, CD9",1.13253251214095,0.434152181326482,FALSE
+"HCC95","Input","KEGG_HISTIDINE_METABOLISM",-0.34838,-1.04,0.356,8524,0.792,"ALDH9A1, ALDH7A1",0.448550002027125,0.101274818410506,FALSE
+"HCC95","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.62976,1.86,0.0275,2505,0.237,"TOP3B, RAD54L, SSBP1, POLD3, BLM, POLD4, POLD1, RPA3, RPA2, MUS81, RAD51, POLD2, RPA1",1.56066730616974,0.625251653989896,TRUE
+"HCC95","Input","KEGG_HUNTINGTONS_DISEASE",-0.21332,-0.627,0.935,5918,1,"NDUFB1, AP2A2, SLC25A31, NDUFA8, DCTN4, NDUFB8, DCTN1, COX5B, NDUFS7, CLTB, CREB5, CLTA, COX7A2, COX4I1, NDUFS2, UQCRQ, HTT, POLR2H, DCTN2, NDUFA3, BAX, SLC25A6, NDUFAB1, CASP3, TBP, GPX1, COX5A, NDUFB4, HDAC2, NDUFB7, COX6C, NDUFA2, COX7C, SLC25A4, CYCS, COX7B, TGM2, ATP5MC2",0.0291883891274822,0,FALSE
+"HCC95","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34948,-1.04,0.374,7768,0.792,"ITGB1, ACTG1, CACNA2D1, TPM3, TGFB3, TPM2, ITGA1, ITGA7, ITGA4, ITGB5, DES, ITGB3, ACE",0.42712839779952,0.101274818410506,FALSE
+"HCC95","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42159,-1.24,0.207,6918,0.657,"PIP4K2C, PI4KA, INPP1, OCRL, INPPL1, PIP4K2A, PIP4K2B, PLCG1, PIK3C2B, ITPKB, SYNJ1, INPP4B, PIK3CB, PI4KB",0.684029654543082,0.182434630440219,FALSE
+"HCC95","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.18628,-0.547,0.974,6195,0.982,"PYGB, MAP2K1, RPS6KB1, EIF4E, RPS6, MAP2K2, PRKAR1A, PIK3R1, HK2, RHEB, PPP1R3D, TRIP10, GSK3B, AKT2, AKT3, FBP1, CBLB, MAPK1, PRKACA, GYS1, PRKAR2B, MAPK3, SOS1, AKT1, INPP5D, SORBS1, PIK3CB, CALM2, PDE3A, GCK, PRKACB",0.0114410431213845,0.00788851221305034,FALSE
+"HCC95","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.26382,-0.762,0.752,6243,0.879,"STAT1, OSM, PTPN11, EPO, CCND1, PIK3R1, STAT5B, PIM1, STAM2, SPRY2, AKT2, IL13RA2, AKT3, CBLB, STAM, SOS1, AKT1, STAT2, PIK3CB, SPRY1, SPRY4",0.123782159408358,0.0560111249262281,FALSE
+"HCC95","Input","KEGG_LEISHMANIA_INFECTION",-0.33228,-0.992,0.435,7269,0.819,"MAPK14, IRAK4, MAPK1, ITGB2, MAPK3, ITGB1, MYD88, TGFB3, PRKCB, ITGA4, CYBA, MARCKSL1",0.361510743045363,0.0867160982395816,FALSE
+"HCC95","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.3173,0.938,0.479,966,0.769,"THY1, CLDN11, JAM3, CLDN6, CLDN1, VAV1, RAC2, MAPK12, CTNND1, F11R, OCLN",0.319664486585437,0.114073660198569,FALSE
+"HCC95","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.74901,-2.25,0,8438,0.21,"YOD1, ALDH9A1, ALDH7A1",Inf,0.677780705266081,TRUE
+"HCC95","Input","KEGG_LONG_TERM_DEPRESSION",-0.28569,-0.831,0.647,7341,0.838,"MAPK1, PRKCA, PRKG1, MAPK3, PPP2CB, PRKCG, PLA2G12A, PRKCB, CACNA1A",0.1890957193313,0.0767559813697235,FALSE
+"HCC95","Input","KEGG_LONG_TERM_POTENTIATION",-0.31122,-0.911,0.543,7247,0.849,"RAP1A, PPP3CC, MAPK1, PRKACA, PRKCA, RAP1B, MAPK3, PRKCG, CALM2, PPP3R1, RPS6KA3, PPP3R2, PRKACB, PRKCB",0.265200170411153,0.0710923097560473,FALSE
+"HCC95","Input","KEGG_LYSINE_DEGRADATION",-0.35242,-1.03,0.376,7895,0.78,"ACAT1, DOT1L, GCDH, ALDH9A1, ALDH7A1",0.424812155072339,0.10790539730952,FALSE
+"HCC95","Input","KEGG_LYSOSOME",-0.33836,-0.994,0.44,6094,0.831,"GGA2, SLC11A2, AP1G1, NAGPA, PLA2G15, AP3M1, PSAPL1, AP3M2, CLTB, CLTA, ARSA, ATP6AP1, FUCA1, GLB1, AP1B1, SMPD1, DNASE2, CTSC, CTSF, CLN3, AP3S1, ACP5, AP1M2, ATP6V0A2, LGMN, GGA3, AP3D1, AGA, ATP6V1H, ATP6V0A1, TCIRG1, CTSK, CTSO, AP3S2, PPT2, IGF2R, SCARB2, NAPSA, GNS, GGA1, ASAH1, MANBA, ATP6V0D1, LIPA, AP1S2, SORT1, CD63, SLC17A5, MCOLN1",0.356547323513813,0.080398976215889,FALSE
+"HCC95","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.21082,-0.606,0.93,7247,0.994,"RAP1A, PPP3CC, MAPK14, MAPK1, PRKACA, PRKCA, PPP5C, CD14, RAP1B, MAPK3, ARRB2, CACNA2D1, SOS1, MAP2K7, AKT1, PRKCG, RASA2, MOS, HSPA1L, MAPKAPK2, TGFB3, MAP3K5, HSPA2, PPP3R1, MAP4K4, RPS6KA3, PPP3R2, PLA2G12A, STMN1, PRKACB, ARRB1, PRKCB, NFATC2, CACNA1A",0.0315170514460649,0.00261361560268669,FALSE
+"HCC95","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.60038,-1.73,0.0307,8205,0.266,"FOXA2, GCK, HNF1A, HNF4A",1.51286162452281,0.575118363368933,FALSE
+"HCC95","Input","KEGG_MELANOGENESIS",-0.29709,-0.88,0.583,7341,0.848,"MAPK1, PRKACA, PRKCA, MAPK3, ADCY5, PRKCG, TYR, CALM2, PRKACB, TYRP1, DCT, ADCY6, PRKCB, MITF",0.234331445240986,0.0716041477432862,FALSE
+"HCC95","Input","KEGG_MELANOMA",0.34645,1.02,0.39,1106,0.734,"EGFR, IGF1R, FGF13, FGF2, KRAS, NRAS, RB1, HRAS, BAD, MET",0.408935392973501,0.134303940083929,FALSE
+"HCC95","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.73845,2.22,0.00226,162,0.104,"ADH4, ADH7, AKR1C2, AKR1C1, AKR1C3, CYP2S1, ALDH3A1, GSTM3",2.6458915608526,0.98296666070122,TRUE
+"HCC95","Input","KEGG_MISMATCH_REPAIR",0.64059,1.86,0.0267,2505,0.237,"MSH3, RFC2, SSBP1, POLD3, MLH1, RFC4, RFC5, POLD4, MSH2, PMS2, POLD1, RPA3, RPA2, POLD2, MSH6, RPA1",1.57348873863542,0.625251653989896,TRUE
+"HCC95","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.44542,-1.34,0.124,6130,0.552,"RPS6KA2, RPS6KB1, EIF4E, RPS6, PIK3R1, RHEB, RPS6KA6, AKT2, AKT3, MAPK1, MAPK3, AKT1, PIK3CB, RPS6KA3, ULK3",0.906578314837765,0.258060922270801,FALSE
+"HCC95","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.29347,0.87,0.605,873,0.815,"IFNGR1, MICA, VAV1, RAET1L, ULBP2, PTPN6, RAC2, KRAS, NRAS, RAC3, LAT, TNFRSF10A",0.218244625347531,0.0888423912600234,FALSE
+"HCC95","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.40838,1.2,0.218,2491,0.596,"GRIN1, NR3C1, PRSS3, F2RL1, HRH1, P2RX4, LTB4R2, CGA, CTSG, F2",0.661543506395395,0.224753740259764,FALSE
+"HCC95","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.20035,-0.598,0.952,6414,0.989,"PTPN11, MAP2K2, PIK3R1, FRS2, RPS6KA6, CAMK2D, BAX, NFKBIB, YWHAQ, GSK3B, AKT2, AKT3, RIPK2, ARHGDIA, RAP1A, MAPK14, IRAK4, ARHGDIB, MAPK1, PLCG1, RAP1B, MAPK3, SOS1, MAP2K7, AKT1, CSK, MAPKAPK2, MAP3K5, PIK3CB, CALM2, RPS6KA3, SORT1, MAGED1, PSEN1",0.0213630516155257,0.0048037084028206,FALSE
+"HCC95","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.62232,-1.86,0.022,8340,0.253,"ENPP1, NT5E, NNMT, NNT, QPRT, BST1",1.65757731917779,0.596879478824182,FALSE
+"HCC95","Input","KEGG_NITROGEN_METABOLISM",-0.67522,-1.98,0.0121,7877,0.197,"CPS1, CA2, GLS, GLS2, CA14, CA8, GLUD2",1.91721462968355,0.705533773838407,TRUE
+"HCC95","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38109,1.1,0.319,684,0.705,"TRAF6, CASP1, IKBKB, IL18, TRIP6, MAPK12",0.496209316942819,0.151810883008601,FALSE
+"HCC95","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.50282,1.48,0.0783,3006,0.349,"XRCC4, POLM, PRKDC, XRCC5, LIG4, FEN1",1.10623823794206,0.45717457304082,FALSE
+"HCC95","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.31675,-0.91,0.532,7718,0.837,"PLCG1, MAPK3, SOS1, AKT1, PRKCG, CDK6, PIK3CB, PRKCB, CDKN2A, RASSF5, FHIT",0.274088367704952,0.07727454200674,FALSE
+"HCC95","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.2818,-0.838,0.642,6983,0.86,"APH1A, NCSTN, LFNG, HDAC2, CIR1, DTX3L, NOTCH2, CTBP2, PSEN2, PSEN1",0.192464971931147,0.0655015487564323,FALSE
+"HCC95","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.58293,1.72,0.0358,2715,0.275,"XPA, DDB2, ERCC5, ERCC8, RAD23B, RFC2, POLD3, RFC4, CUL4A, RFC5, ERCC1, CDK7, GTF2H1, MNAT1, POLD4, POLE, GTF2H4, ERCC4, ERCC3, POLD1, RPA3, GTF2H3, RPA2, GTF2H5, DDB1, POLE4, RBX1, POLD2, XPC, CCNH, RPA1, ERCC2, GTF2H2",1.44611697335613,0.560667306169737,FALSE
+"HCC95","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.29047,0.871,0.606,1414,0.827,"ALG13, ALG12, ST6GAL1, MAN2A1, ALG2, MGAT1, MGAT4B, B4GALT1, MAN1A1",0.217527375833714,0.0824944904474534,FALSE
+"HCC95","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.58963,-1.73,0.0344,7045,0.266,"PDC, PRKACA, PRKG1, ARRB2, CALM2, PRKACB, PDE1C",1.46344155742847,0.575118363368933,FALSE
+"HCC95","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.38196,-1.12,0.275,6210,0.706,"ATIC, MTHFS, GART, MTHFR, MTR, TYMS",0.560667306169737,0.151195298948196,FALSE
+"HCC95","Input","KEGG_OOCYTE_MEIOSIS",-0.19859,-0.582,0.958,6621,0.977,"CCNB2, PPP2R5B, RPS6KA6, CAMK2D, YWHAQ, MAD2L1, PPP2R5A, PLK1, PPP3CC, MAPK1, PRKACA, MAPK3, PPP2CB, ADCY5, MOS, SGO1, CALM2, PPP3R1, CDK2, RPS6KA3, PPP3R2, PRKACB, ADCY6",0.0186344909214556,0.0101054362812269,FALSE
+"HCC95","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.20024,-0.613,0.953,6439,0.999,"FUCA1, GLB1, FUCA2, AGA, MANBA",0.0209070993616736,0.000434511774017692,FALSE
+"HCC95","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.43404,-1.27,0.167,6417,0.619,"COX7A2, ATP6AP1, COX4I1, NDUFS2, UQCRQ, NDUFA3, NDUFAB1, ATP6V1B1, PPA1, COX5A, ATP6V0A2, NDUFB4, ATP6V1F, ATP6V1H, PPA2, NDUFB7, ATP6V1B2, ATP6V1A, ATP6V1C2, COX6C, ATP6V0A1, TCIRG1, NDUFA2, ATP6V1C1, ATP6V1D, ATP6V1E1, COX7C, ATP6V1G1, ATP6V0D1, COX7B, ATP5MC2, COX17",0.777283528852417,0.208309350979882,FALSE
+"HCC95","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.46048,-1.32,0.14,7735,0.566,"GALNT6, B4GALT5, ST3GAL2, C1GALT1C1, C1GALT1, GALNT16, GALNT17",0.853871964321762,0.247183568811729,FALSE
+"HCC95","Input","KEGG_P53_SIGNALING_PATHWAY",-0.31951,-0.941,0.484,7931,0.84,"CD82, RCHY1, CDK6, CYCS, CDK2, COP1, RRM2, CDKN2A, TP53I3",0.315154638355588,0.0757207139381184,FALSE
+"HCC95","Input","KEGG_PANCREATIC_CANCER",0.24554,0.748,0.789,1105,0.851,"EGFR, IKBKB, TGFB2, RAC2, SMAD3, KRAS, RAC3, RB1, BAD",0.10292299679058,0.0700704399154121,FALSE
+"HCC95","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.42371,1.25,0.186,320,0.605,"BCAT2, BCAT1",0.730487055782084,0.218244625347531,FALSE
+"HCC95","Input","KEGG_PARKINSONS_DISEASE",-0.2927,-0.881,0.581,6229,0.86,"COX5B, NDUFS7, PARK7, COX7A2, COX4I1, NDUFS2, UQCRQ, NDUFA3, SLC25A6, UBE2G2, NDUFAB1, UBE2G1, UBE2L6, UBE2L3, CASP3, COX5A, NDUFB4, NDUFB7, COX6C, NDUFA2, UBA1, COX7C, UBE2J1, SLC25A4, CYCS, COX7B, SLC18A1, ATP5MC2",0.235823867609669,0.0655015487564323,FALSE
+"HCC95","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.34548,-0.988,0.411,5571,0.812,"EZR, NCK2, FYN, ARPC4, TUBB1, ACTB, WASL, TUBA1B, ARPC5, TUBB3, NCL, TUBA1C, TUBB, TUBB2A, CTNNB1, YWHAQ, TUBA3C, ARPC3, ROCK1, ROCK2, ARHGEF2, TUBB6, PRKCA, HCLS1, CD14, ITGB1, ACTG1, TUBB2B",0.386158178123931,0.0904439707588247,FALSE
+"HCC95","Input","KEGG_PATHWAYS_IN_CANCER",0.29121,0.864,0.613,1460,0.801,"EGFR, SLC2A1, FZD1, TRAF6, LAMA1, WNT5A, RXRA, ITGA2, ITGA6, AR, LAMB3, PML, IKBKB, ITGA3, IGF1R, FZD6, LAMC2, TGFB2, RAC2, JUN, GSTP1, FGF13, FGF2, SMAD3, LAMA5, KRAS, NRAS, RAC3, RB1, RARA, HRAS, MSH3, BAD, MET, PTGS2, MYC, MLH1, FZD2, BCL2L1, DVL3, CDKN1B, FH, STAT3",0.212539525481585,0.0963674839157623,FALSE
+"HCC95","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.30188,0.898,0.563,771,0.812,"AKR1B1, UGDH",0.249491605148654,0.0904439707588247,FALSE
+"HCC95","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.26871,-0.796,0.713,7036,0.872,"RPE, FBP1, PFKL, DERA, PFKP, RBKS, RPIA, PGM1",0.146910470148134,0.0594835150674328,FALSE
+"HCC95","Input","KEGG_PEROXISOME",-0.38494,-1.14,0.259,7196,0.681,"PEX26, PEX11A, ECI2, AMACR, ABCD4, PEX16, AGPS, ABCD3, HSD17B4, ACSL6, PEX6, SCP2, PEX12, PEX1, ABCD1, DECR2, PECR, IDH2, PEX19, ACOX3, ACOT8, ACAA1, ACSL1, HACL1, ACSL5, FAR2",0.586700235918748,0.166852888087215,FALSE
+"HCC95","Input","KEGG_PHENYLALANINE_METABOLISM",0.64089,1.94,0.0149,1060,0.223,"ALDH3A1, GOT2, MAOA",1.82681373158773,0.651695136951839,TRUE
+"HCC95","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.41044,-1.19,0.239,6918,0.696,"PIP4K2C, PI4KA, INPP1, PRKCA, OCRL, INPPL1, PIP4K2A, PIP4K2B, PLCG1, PIK3C2B, ITPKB, PRKCG, SYNJ1, INPP4B, INPP5D, PIK3CB, CALM2, PI4KB, PRKCB",0.621602099051862,0.157390760389438,FALSE
+"HCC95","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.3439,-1.03,0.378,7114,0.78,"EARS2, UROD, CPOX, PPOX, HMOX1, HCCS, UROS",0.422508200162775,0.10790539730952,FALSE
+"HCC95","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.37255,-1.09,0.309,7286,0.751,"ACADM, GK2, SLC27A4, FABP6, FABP5, ILK, DBI, ACSL6, FABP3, SCP2, SORBS1, FABP4, ACOX3, GK, ACAA1, ACSL1, CYP27A1, ACSL5",0.510041520575165,0.124360062995832,FALSE
+"HCC95","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.46461,1.35,0.134,37,0.515,"AKR1D1",0.872895201635192,0.288192770958809,FALSE
+"HCC95","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.31845,0.95,0.511,1341,0.773,"CD40, TAP1, TAP2",0.291579099865287,0.111820506081675,FALSE
+"HCC95","Input","KEGG_PRION_DISEASES",0.33232,0.977,0.441,563,0.762,"C9, PRNP",0.355561410532161,0.1180450286604,FALSE
+"HCC95","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21599,-0.635,0.934,6530,1,"PIK3R1, CCNB2, RPS6KA6, AKT2, MAD2L1, PLK1, AKT3, MAPK14, MAPK1, PRKACA, MAPK3, ADCY5, AKT1, MOS, PIK3CB, CDK2, PDE3A, RPS6KA3, PRKACB, ADCY6",0.0296531237699066,0,FALSE
+"HCC95","Input","KEGG_PROPANOATE_METABOLISM",-0.46237,-1.38,0.12,7870,0.5,"LDHA, ACAT1, SUCLG2, ACSS3, ALDH9A1, ALDH7A1",0.920818753952375,0.301029995663981,FALSE
+"HCC95","Input","KEGG_PROSTATE_CANCER",0.37258,1.09,0.301,1105,0.689,"EGFR, AR, IKBKB, IGF1R, GSTP1, KRAS, NRAS, RB1, ATF4, HRAS, BAD",0.521433504406157,0.161780778092374,FALSE
+"HCC95","Input","KEGG_PROTEASOME",0.52184,1.58,0.058,3172,0.341,"PSMB9, PSMB8, PSMB10, PSME1, PSMB4, PSME2, PSME4, POMP, PSMB3, PSMB7, PSMA4, PSME3, PSMA8, PSMC2, PSMA2, PSMF1, PSMB2, PSMA6, PSMB5, PSMA1, PSMD12, PSMD4, PSMC4, PSMA7, PSMB1, PSMC3, PSMC5, PSMC1",1.23657200643706,0.467245621007502,FALSE
+"HCC95","Input","KEGG_PROTEIN_EXPORT",-0.28253,-0.836,0.672,7078,0.852,"SPCS2, SEC11A, IMMP1L, SEC11C",0.172630726946175,0.0695604052332999,FALSE
+"HCC95","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.39349,-1.14,0.259,7991,0.681,"CA2, GLS, GLS2, GLUD2",0.586700235918748,0.166852888087215,FALSE
+"HCC95","Input","KEGG_PURINE_METABOLISM",-0.36054,-1.05,0.35,7213,0.806,"AK2, AMPD2, APRT, NPR1, POLA2, GDA, PDE4D, POLA1, ADCY5, GMPR, PRUNE1, AK1, ENPP1, PDE3A, NPR2, PAPSS2, RRM2, NT5E, ADCY6, NME4, FHIT, PDE4A, PDE1C",0.455931955649724,0.0936649581949093,FALSE
+"HCC95","Input","KEGG_PYRIMIDINE_METABOLISM",-0.27985,-0.832,0.645,7477,0.848,"POLA2, TYMP, CMPK1, CTPS1, UMPS, POLA1, TYMS, CTPS2, RRM2, NT5E, NME4, TK1, TK2",0.190440285364732,0.0716041477432862,FALSE
+"HCC95","Input","KEGG_PYRUVATE_METABOLISM",-0.40539,-1.2,0.227,7239,0.697,"PDHA1, ACYP2, PDHB, HAGH, LDHA, ACAT1, ME3, ACYP1, ALDH9A1, ALDH7A1",0.643974142806877,0.156767221901991,FALSE
+"HCC95","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.23428,0.678,0.865,733,0.911,"EGFR, ITGB4, PFN2, ITGA2, IQGAP2, ITGA6, VAV1, ITGA5, ITGA3, RAC2, GNA13, ITGB8, FGF13, FGF2, KRAS, NRAS, RAC3",0.0629838925351858,0.0404816230270017,FALSE
+"HCC95","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.62807,-1.83,0.0293,6893,0.225,"ATG4C, ATG4A, GABARAPL1, ATG4B, ATG3, ULK3, GABARAPL2",1.53313237964589,0.647817481888638,TRUE
+"HCC95","Input","KEGG_RENAL_CELL_CARCINOMA",0.20618,0.61,0.942,1106,0.971,"SLC2A1, TGFB2, JUN, KRAS, NRAS, HRAS, MET",0.0259490972071227,0.0127807700919951,FALSE
+"HCC95","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.55799,-1.64,0.0443,7272,0.252,"MME, ANPEP, CPA3, ACE",1.35359627377693,0.598599459218456,FALSE
+"HCC95","Input","KEGG_RETINOL_METABOLISM",0.71108,2.17,0.00407,314,0.101,"ADH4, ADH7, DHRS3",2.39040559077478,0.995678626217357,TRUE
+"HCC95","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.65588,-1.93,0.00938,6852,0.209,"ACP1, ACP5, PHPT1, TYR, MTMR6, ENPP1",2.02779716162094,0.679853713888946,TRUE
+"HCC95","Input","KEGG_RIBOSOME",0.2264,0.69,0.883,3922,0.906,"RPL22L1, RPL37, RPL29, RPL26L1, RPL32, RPL4, RPS27A, RPL37A, RPL14, RPL27, RPL24, RSL24D1, RPSA, RPL34, RPS12, RPS16, RPL36A, RPL36AL, RPL35A, RPL27A, RPL7A, RPL35, RPL13A, RPS3A, RPL10A, FAU, RPS8, RPS11, RPS15A, UBA52, RPS3, RPL21, RPL19, RPL36, RPL23, RPL23A, RPLP0, RPS26, RPL30",0.0540392964224314,0.0428718023231869,FALSE
+"HCC95","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.27389,-0.802,0.694,5873,0.872,"ATG12, MAPK8, TKFC, TBK1, FADD, MAP3K7, PIN1, DHX58, NFKBIB, IRF3, CYLD, OTUD5, MAPK14, TRAF3, DDX58, ISG15, RIPK1, DDX3Y",0.158640529545145,0.0594835150674328,FALSE
+"HCC95","Input","KEGG_RNA_DEGRADATION",0.2515,0.749,0.77,3336,0.861,"PAPOLG, EXOSC1, LSM4, DIS3, EXOSC3, EXOSC8, EXOSC6, EXOSC9, PARN, EXOSC4, LSM6, EXOSC5, C1D, HSPA9, SKIV2L, PNPT1, CNOT6, XRN2, EXOSC2, LSM3, MTREX, EDC3, EXOSC7, LSM8, XRN1, ZCCHC7, LSM7, LSM2, TTC37",0.113509274827518,0.0649968485463452,FALSE
+"HCC95","Input","KEGG_RNA_POLYMERASE",0.24366,0.705,0.853,6706,0.896,"POLR3G, POLR1E, POLR1B, POLR1A, POLR2G, POLR2K, POLR1C, POLR1D, POLR2J, POLR2L, POLR2E, POLR2I, POLR2A, POLR2D, POLR2C, POLR3C, POLR2B, POLR2F, POLR3H, POLR3F, POLR3K, POLR3A, POLR3D, POLR2H, POLR3B, POLR3GL",0.069050968832477,0.0476919903378748,FALSE
+"HCC95","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.25909,0.765,0.738,1348,0.844,"BUD23, SCLY, MAT1A, METTL2B, MAT2B",0.131943638176958,0.073657553374345,FALSE
+"HCC95","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.30067,0.889,0.557,431,0.817,"TRAF6, LAMA1, RXRA, ITGA2, ITGA6, LAMB3, IKBKB, ITGA3, LAMC2",0.254144804826271,0.0877779434675845,FALSE
+"HCC95","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.48851,-1.43,0.1,6947,0.461,"STX18, STX6, VTI1B, VTI1A, SNAP47, SEC22B, SNAP29, VAMP7, VAMP4, STX12, YKT6, STX7, STX3",1,0.336299074610352,FALSE
+"HCC95","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33855,0.99,0.406,1337,0.75,"PLPP1, KDSR, GLA, GALC, NEU3, SGPL1, UGT8",0.391473966422806,0.1249387366083,FALSE
+"HCC95","Input","KEGG_SPLICEOSOME",0.27153,0.784,0.714,3431,0.821,"DHX8, NCBP1, DHX38, CRNKL1, SLU7, LSM4, DDX42, EFTUD2, SNU13, HSPA1A, TXNL4A, LSM6, PRPF6, PRPF38A, PRPF19, AQR, SNRPB, HSPA6, PPIE, ZMAT2, BCAS2, PPIL1, DDX46, PRPF18, THOC3, ISY1, CCDC12, SF3A2, SNRPD3, EIF4A3, SNRPF, NCBP2, SNRNP200, LSM3, PRPF8, TCERG1, HNRNPK, SF3B5, PLRG1, DDX39B, USP39, SNRPG, SNRPD1, SNRPD2, PRPF40B, LSM8, SF3B6, SF3A1, SNW1, HNRNPA3, ALYREF, SNRNP70, DDX23, SMNDC1, THOC2, LSM7, LSM2, CDC5L, SF3B1, TRA2B, SF3A3, DDX5, SNRNP40, HNRNPC, SNRPC",0.146301788223826,0.0856568428805592,FALSE
+"HCC95","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.29046,-0.858,0.591,7465,0.844,"GYS1, GBE1, ENPP1, GCK, PGM1",0.228412519118745,0.073657553374345,FALSE
+"HCC95","Input","KEGG_STEROID_BIOSYNTHESIS",-0.38885,-1.15,0.266,7136,0.719,"HSD17B7, CYP51A1, SOAT1, TM7SF2, CEL, LIPA",0.575118363368933,0.143271109617117,FALSE
+"HCC95","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.79115,2.35,0,37,0.0912,"AKR1C2, AKR1C1, AKR1C3, AKR1D1",Inf,1.04000516167158,TRUE
+"HCC95","Input","KEGG_SULFUR_METABOLISM",-0.75757,-2.22,0.00712,8250,0.133,"CHST11, PAPSS2, SULT1A3, SULT1A1",2.14752000636314,0.876148359032914,TRUE
+"HCC95","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.68017,2,0.013,224,0.209,"C9, C3, CD40",1.88605664769316,0.679853713888946,TRUE
+"HCC95","Input","KEGG_TASTE_TRANSDUCTION",-0.6437,-1.85,0.0314,8551,0.233,"PRKACB, ADCY6, CACNA1A",1.50307035192679,0.632644078973981,TRUE
+"HCC95","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.54274,-1.59,0.062,7115,0.275,"IDI1, HMGCR, MVD, FDPS, ACAT1",1.20760831050175,0.560667306169737,FALSE
+"HCC95","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.30931,-0.885,0.549,7152,0.866,"ROCK1, ROCK2, SMAD5, MAPK1, MAPK3, PPP2CB, TGFB3, ZFYVE9, INHBE, SMAD2",0.260427655549908,0.0624821079826534,FALSE
+"HCC95","Input","KEGG_THYROID_CANCER",0.28918,0.855,0.582,1129,0.781,"RXRA, KRAS, NRAS, HRAS, MYC",0.235077015350112,0.1073489661227,FALSE
+"HCC95","Input","KEGG_TIGHT_JUNCTION",0.28629,0.861,0.628,1088,0.794,"CLDN11, JAM3, MYH4, CLDN6, CLDN1, YES1, EPB41L1, YBX3, KRAS, NRAS, PATJ, SRC, F11R, OCLN, HRAS, ACTN4",0.202040356262804,0.100179497572904,FALSE
+"HCC95","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29647,-0.847,0.614,6156,0.855,"TLR9, MAP2K1, STAT1, TBK1, FADD, MAP3K7, MAP2K2, PIK3R1, MAP2K3, MAP2K4, AKT2, IRF3, AKT3, MAPK14, IRAK4, MAPK1, TRAF3, TOLLIP, CD14, CTSK, MAPK3, MAP2K7, AKT1, MYD88, PIK3CB, RIPK1",0.211831628858832,0.0680338852718274,FALSE
+"HCC95","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.38548,-1.14,0.266,7805,0.681,"KMO, ACAT1, GCDH, ALDH9A1, ALDH7A1",0.575118363368933,0.166852888087215,FALSE
+"HCC95","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.28783,0.854,0.618,498,0.771,"PDX1, ABCC8, IKBKB, IRS1",0.209011524911184,0.112945621949043,FALSE
+"HCC95","Input","KEGG_TYROSINE_METABOLISM",0.54225,1.61,0.0533,1060,0.326,"ADH4, ADH7, ALDH3A1, BUD23, GOT2, METTL2B, MAOA",1.27327279097343,0.486782399932061,FALSE
+"HCC95","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26284,-0.769,0.754,6772,0.877,"NFKBIB, GSK3B, AKT2, NFAT5, AKT3, PPP3CC, MAPK14, CBLB, MAPK1, PLCG1, MAPK3, SOS1, MAP2K7, AKT1, PIK3CB, PPP3R1, PPP3R2, NFATC2, PTPRC, GRAP2",0.122628654130226,0.0570004066339595,FALSE
+"HCC95","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18932,0.553,0.984,1462,0.98,"TRAF6, PML, UBE2H, DDB2, CDC23, ANAPC4, CDC16, ANAPC7, FBXO4, NEDD4, ANAPC5, CDC26, ERCC8, CDC27, CUL4A, UBE2Z, FBXO2, UBE3C, FBXW11, ANAPC1",0.00700490156865849,0.00877392430750515,FALSE
+"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.61955,1.81,0.0213,320,0.26,"BCAT2, BCAT1",1.67162039656126,0.585026652029182,FALSE
+"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.31255,-0.919,0.501,7895,0.86,"ACAT1, ACAA2, HSD17B10, ALDH9A1, ACAA1, ALDH7A1",0.300162274132754,0.0655015487564323,FALSE
+"HCC95","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.48012,-1.41,0.102,7096,0.472,"ARHGEF1, ROCK1, ROCK2, PRKCE, MAPK1, PRKACA, PRKCA, NPR1, PRKG1, MAPK3, ADCY5, PRKCG, PPP1R12B, ARHGEF11, KCNMA1, MYLK, CALM2, CALD1, NPR2, PLA2G12A, PRKACB, ADCY6, PRKCB",0.991399828238082,0.326058001365912,FALSE
+"HCC95","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.40177,-1.18,0.242,5979,0.695,"RAB5C, DCTN4, DCTN1, NSF, CREB5, RAB11A, DCTN2, ARHGDIA, ARHGDIB, PRKACA, RAB5B, DYNC1LI1, RAB5A, RAB11B, PRKACB, ADCY6",0.616184634019569,0.158015195409886,FALSE
+"HCC95","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32187,-0.947,0.485,6854,0.857,"AKT2, NFAT5, MAPKAPK3, AKT3, PPP3CC, MAPK14, MAPK1, PRKCA, PLCG1, MAPK3, AKT1, PRKCG, MAPKAPK2, PIK3CB, PPP3R1, PPP3R2, PLA2G12A, PRKCB, NFATC2, SPHK2",0.314258261397736,0.0670191780768018,FALSE
+"HCC95","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.58265,-1.72,0.028,7120,0.255,"ATP6V0A2, ATP6V1F, ATP6V1H, PRKACA, PRKCA, ATP6V1B2, ATP6V1A, ATP6V1C2, ATP6V0A1, TCIRG1, ATP6V1C1, ATP6V1D, PLCG1, KDELR3, ATP6V1E1, ACTG1, ATP6V1G1, PRKCG, TJP2, ATP6V0D1, PRKACB, PRKCB",1.55284196865778,0.593459819566045,FALSE
+"HCC95","Input","KEGG_VIRAL_MYOCARDITIS",0.36306,1.08,0.317,733,0.675,"CAV1, MYH4, CD40, RAC2, RAC3",0.498940737782249,0.170696227168975,FALSE
+"HCC95","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24695,-0.72,0.861,6641,0.93,"PPP2R5B, CAMK2D, CTNNB1, DAAM2, WNT11, CXXC4, GSK3B, NFAT5, PPP2R5A, ROCK1, ROCK2, PPP3CC, CACYBP, PRKACA, PRKCA, DAAM1, PPP2CB, CTBP2, PRKCG, VANGL2, NKD1, NKD2, FOSL1, PPP3R1, PPP3R2, PRKACB, PRKCB, NFATC2, PSEN1, SMAD2",0.0649968485463452,0.0315170514460649,FALSE
+"H1650","Input","KEGG_ABC_TRANSPORTERS",-0.42713,-1.31,0.159,7453,0.456,"ABCC10, ABCC2, ABCD4, ABCA10, ABCB1, ABCA3, ABCC5, ABCB6, ABCC4, ABCB4",0.798602875679548,0.341035157335565,FALSE
+"H1650","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.18586,-0.576,0.951,7475,0.985,"STAT5A, STAT5B, PIM1, IKBKB, EIF4EBP1, MYC",0.0218194830625861,0.00656376950238827,FALSE
+"H1650","Input","KEGG_ADHERENS_JUNCTION",0.37331,1.13,0.293,2728,0.479,"ERBB2, CTNNA1, CTNNB1, NECTIN1, TGFBR2, CTNND1, CTNNA2, EGFR, PTPRM, SMAD3, PTPRJ, PTPRF, MAPK3, MAP3K7, NECTIN2, CDH1, BAIAP2, ACTN4, PTPN1, CREBBP, EP300, ACTG1, SRC, CDC42, SMAD2, RAC1, NECTIN4, FYN, ACTN1, CSNK2A1, CSNK2A2, VCL, ACTB, RHOA, PTPN6",0.533132379645891,0.319664486585437,FALSE
+"H1650","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.44472,1.39,0.101,2213,0.368,"CD36, PRKCQ, RXRA, SLC2A1, ACSL1, TRADD, ACSL5, ACSL6, STAT3, AKT2, AKT3, PRKAA1, MTOR, CHUK, ACACB, CPT1A, NFKB1",0.995678626217357,0.434152181326482,FALSE
+"H1650","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.49748,1.52,0.0607,1055,0.335,"ABAT, GLUL, ASS1, GLS, GLS2, GPT2",1.21681130892474,0.474955192963155,FALSE
+"H1650","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.32604,0.993,0.422,1661,0.628,"ATP1B3, SFN, ATP1B1, MAPK3, ATP1A3, PIK3R3, ATP1A1, ATP1A4, PRKCA",0.374687549038326,0.202040356262804,FALSE
+"H1650","Input","KEGG_ALZHEIMERS_DISEASE",0.19217,0.604,0.962,1731,0.977,"NDUFA2, PPP3R2, MME, PPP3R1, CAPN2, PPP3CA, CAPN1, PPP3CB, CYC1, UQCR10, SDHD, ITPR2, FAS, GAPDH, CASP7, MAPK3, ATP2A2, EIF2AK3, SDHC, CYCS, GNAQ, COX6A1, CASP8",0.0168249279621871,0.0101054362812269,FALSE
+"H1650","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.45506,-1.41,0.111,6631,0.423,"MARS2, MTFMT, PARS2, HARS2, AARS2, NARS2, CARS2, TARS2, WARS2",0.954677021213343,0.373659632624958,FALSE
+"H1650","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.24495,0.77,0.763,1750,0.837,"PGM1, MPI, NAGK, GNE, UGP2, UAP1, CYB5R3, GMPPB, GMPPA, HEXA, HK1",0.11747546204512,0.07727454200674,FALSE
+"H1650","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.30793,-0.954,0.478,8445,0.656,"NEFH, NEFM, PRPH, PRPH2, NEFL, TP53",0.320572103387881,0.18309616062434,FALSE
+"H1650","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.60892,1.87,0.0208,1015,0.182,"CD74, HSPA2, HSPA1L, TAPBP, CTSL, B2M, TAP1, HSPA6, TAP2",1.68193666503724,0.739928612014925,TRUE
+"H1650","Input","KEGG_APOPTOSIS",0.39026,1.15,0.265,1731,0.483,"PPP3R2, ENDOD1, PPP3R1, PRKACB, CAPN2, PPP3CA, CAPN1, PPP3CB, PRKAR1B, TRADD, ENDOG, PRKAR1A, FAS, MYD88, CASP7, AKT2, AKT3, PIK3R3, CYCS, PRKACA, CASP8",0.576754126063192,0.316052869248488,FALSE
+"H1650","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.45723,1.33,0.157,485,0.357,"PTGES, GGT1, CYP4F3, GPX6, GPX7",0.804100347590766,0.447331783887807,FALSE
+"H1650","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.29352,0.896,0.566,1107,0.704,"GLUL, ALDH7A1, GATM, P4HA1, PYCR3, ASS1, AOC1, DAO, GLS, GLS2, OAT, P4HA2",0.247183568811729,0.152427340857888,FALSE
+"H1650","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.46079,1.41,0.121,1475,0.362,"ITGA4, ITGA6, ITGA3, ITGB4, ITGA1, ITGB1, ITGA2, ITGA5, SLC8A1, CTNNA1, CTNNB1, ITGB5, DSC2, CTNNA2, DSG2, DAG1, ITGAV, ITGB8, PKP2, ACTN4, ATP2A2, LMNA",0.91721462968355,0.441291429466834,FALSE
+"H1650","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.57795,-1.77,0.0333,8393,0.366,"UGDH, ALDH2, ALDH1B1",1.47755576649368,0.436518914605589,FALSE
+"H1650","Input","KEGG_AXON_GUIDANCE",0.25901,0.824,0.676,1221,0.795,"ITGB1, PPP3R2, EPHB2, NFAT5, PPP3R1, SEMA3C, EFNA5, PPP3CA, PPP3CB, EPHB4, NTN4, SEMA4B, PTK2, SRGAP2, SRGAP3, RASA1, LIMK2, CFL2, MAPK3",0.170053304058364,0.0996328713435297,FALSE
+"H1650","Input","KEGG_BASAL_CELL_CARCINOMA",0.44841,1.37,0.123,763,0.358,"FZD2, FZD1, CTNNB1, APC",0.910094888560602,0.446116973356126,FALSE
+"H1650","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.57937,-1.82,0.0245,6190,0.498,"TAF12, GTF2E1, TAF7, TAF10, TAF9, GTF2E2, GTF2IRD1, GTF2H3, GTF2H4, GTF2H2, GTF2H1, GTF2F2, GTF2F1, TAF9B",1.61083391563547,0.302770657240282,FALSE
+"H1650","Input","KEGG_BASE_EXCISION_REPAIR",-0.49377,-1.53,0.0873,7094,0.331,"MBD4, POLE3, APEX1, MPG, FEN1, PARP1, PARP2, HMGB1, POLB",1.05898575629443,0.480172006224281,FALSE
+"H1650","Input","KEGG_BETA_ALANINE_METABOLISM",0.43588,1.33,0.154,330,0.357,"ABAT, ALDH7A1",0.812479279163537,0.447331783887807,FALSE
+"H1650","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.76918,2.38,0,966,0.0373,"ACOT4, SCD5, ACOT1, ACOX3, FADS2, SCD, ACOT2, ACAA1, TECR, ACOX1",Inf,1.42829116819131,TRUE
+"H1650","Input","KEGG_BLADDER_CANCER",-0.35229,-1.09,0.305,8588,0.604,"E2F3, RB1, TP53, MYC",0.515700160653214,0.218963061378868,FALSE
+"H1650","Input","KEGG_BUTANOATE_METABOLISM",0.31998,0.986,0.424,2397,0.626,"ABAT, ALDH7A1, ALDH3A2, OXCT1, AKR1B10, ACAT2, AACS, HMGCS1, ALDH5A1, EHHADH",0.372634143407267,0.20342566678957,FALSE
+"H1650","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31122,0.951,0.442,1393,0.646,"PPP3R2, NFAT5, MALT1, PPP3R1, PPP3CA, PPP3CB, VAV2, MAPK3, AKT2, AKT3, PIK3R3, SOS1",0.354577730650908,0.189767482004916,FALSE
+"H1650","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.47802,1.48,0.106,1687,0.349,"GNA15, CAMK2G, ERBB4, BST1, PPP3R2, CAMK2B, ERBB2, PTK2B, PPP3R1, PRKACB, SLC8A1, PPP3CA, PPP3CB, PLCD1, PHKB, PHKA1, CAMK2D, EGFR, ATP2B1, TACR1, ITPR2, GNAS, ATP2B2, ATP2B4, ADCY3, ADCY8, P2RX4, SPHK2, VDAC2, ATP2A2, TNNC1, PRKACA, PRKCA, GNAQ",0.97469413473523,0.45717457304082,FALSE
+"H1650","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.5211,1.59,0.0626,2768,0.317,"TPM2, SLC8A1, CYC1, UQCR10, TPM1, SLC9A6, SLC9A1, ATP1B3, ATP1B1, ATP1A3, ATP2A2, ATP1A1, ATP1A4, TNNC1, COX6A1, UQCRC2, UQCRFS1, CACNA2D2, UQCRC1, UQCRQ, COX6B1, COX7A2, COX7A2L, COX4I1, UQCRH, TPM4",1.20342566678957,0.498940737782249,FALSE
+"H1650","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.50982,1.57,0.0522,1325,0.326,"ITGA4, CD40, SDC1, CLDN6, SDC4, ITGA6, ITGB2, CD99, GLG1, ITGB1, CLDN4, CD274, CDH15, CDH3, F11R, SDC2, NECTIN1, OCLN, PVR, SDC3, ITGAV, PTPRM, CD276, PTPRF, ITGB8, NECTIN2, CDH1",1.28232949699774,0.486782399932061,FALSE
+"H1650","Input","KEGG_CELL_CYCLE",-0.3834,-1.17,0.238,6889,0.512,"ORC4, MCM5, CDK7, ORC5, MCM2, MCM4, CDK6, STAG1, ORC3, MCM6, MCM7, CDKN2C, TGFB2, ORC1, TGFB3, MCM3, ORC2, HDAC2, ATM, ORC6, TFDP1, CDC20, ABL1, E2F3, RB1, TP53, MYC, CDKN1B",0.623423042943488,0.290730039024169,FALSE
+"H1650","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.35263,1.1,0.333,1817,0.511,"STAT1, STAT2, PTK2B, PRKACB, ADCY6, TIAM1, ADCY5, PRKCD, PRKCZ, CCL15, VAV2, PTK2, ADCY3, ADCY8, GNG10, STAT3, TIAM2, MAPK3, ARRB1, AKT2, AKT3, PIK3R3, SOS1, PXN, CXCL6, GNG12, LYN, PRKACA, CXCR4, GNG5, ROCK1, RAP1A",0.47755576649368,0.291579099865287,FALSE
+"H1650","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.41892,-1.3,0.167,7475,0.427,"STAT5A, CTBP1, TGFB2, STAT5B, TGFB3, TGFBR1, HDAC2, IKBKB, ABL1, E2F3, RB1, GAB2, TP53, MYC, CDKN1B",0.777283528852417,0.369572124974976,FALSE
+"H1650","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.34031,1.01,0.409,2573,0.606,"SDHD, ACLY, OGDHL, PC, SDHC, OGDH, ACO2, SUCLG2, SDHB, IDH1, MDH1, DLD, SDHA, IDH2",0.388276691992658,0.217527375833714,FALSE
+"H1650","Input","KEGG_COLORECTAL_CANCER",-0.21185,-0.653,0.915,7444,0.934,"MAPK8, TGFB2, TGFB3, TGFBR1, JUN, TP53, MYC",0.0385789059335517,0.0296531237699066,FALSE
+"H1650","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.36354,1.09,0.33,973,0.52,"SERPINA1, PLAU, CD59, F8, CD55, PROC, C3, MBL2, PLAUR",0.481486060122112,0.283996656365201,FALSE
+"H1650","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.53674,-1.66,0.0454,7781,0.306,"MPST, APIP, AMD1, CTH, MTAP",1.3429441471429,0.51427857351842,FALSE
+"H1650","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.428,1.35,0.125,1738,0.356,"CD40, IFNGR1, IL18, TGFBR2, CCL15, KITLG, EGFR, LTBR, FAS, TNFRSF12A, HGF, CXCL6, FLT3, CXCR4, EPO",0.903089986991944,0.448550002027125,FALSE
+"H1650","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.40082,1.23,0.187,640,0.407,"DDX58, CASP1, IL18, IRF3, ZBP1",0.728158393463501,0.39040559077478,FALSE
+"H1650","Input","KEGG_DILATED_CARDIOMYOPATHY",0.48962,1.54,0.0732,1200,0.337,"ITGA4, ITGA6, ITGA3, ITGB4, TPM2, ITGA1, ITGB1, ITGA2, ITGA5, PRKACB, ADCY6, SLC8A1, ITGB5, ADCY5, TPM1, DAG1, GNAS, ITGAV, ADCY3, ADCY8, ITGB8",1.13548891894161,0.472370099128661,FALSE
+"H1650","Input","KEGG_DNA_REPLICATION",-0.53658,-1.69,0.0382,5305,0.31,"SSBP1, POLD3, RFC2, RFC3, RFC5, RPA3, POLD2, RPA2, RPA1, RNASEH1, DNA2, PRIM1, RFC1, POLA1, MCM5, RFC4, MCM2, MCM4, POLE3, MCM6, PRIM2, MCM7, POLA2, FEN1, MCM3, RNASEH2A, RNASEH2C, RNASEH2B",1.41793663708829,0.508638306165727,FALSE
+"H1650","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.48056,1.47,0.0934,2564,0.35,"EGFR, NOTCH3, MAPK3, SOS1, NOTCH2, SPIRE1",1.02965312376991,0.455931955649724,FALSE
+"H1650","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.588,-1.79,0.0434,7630,0.421,"ADH4, ADH7, GSTZ1, FMO3, ALDH3A1, GSTM4, ADH1C, GSTM3, MAOA, GSTM2, GSTM1, GSTP1",1.36251027048749,0.375717904164332,FALSE
+"H1650","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.37646,1.16,0.232,1024,0.475,"CDA, TYMP, TK1, TK2, CES1, CES2",0.6345120151091,0.323306390375133,FALSE
+"H1650","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.52697,1.63,0.0351,1250,0.299,"ITGA4, SDC1, SDC4, ITGA6, ITGA3, ITGB4, CD36, ITGA1, ITGB1, LAMA5, ITGA2, ITGA5, SDC2, ITGB5, LAMA3, LAMA4, DAG1, SDC3, ITGAV, LAMB1, ITGB8, COL5A1",1.45469288353418,0.52432881167557,FALSE
+"H1650","Input","KEGG_ENDOCYTOSIS",0.52654,1.64,0.0393,2260,0.319,"DNM3, HSPA2, TRAF6, EHD2, HSPA1L, EPN3, ERBB4, ASAP3, DAB2, EHD1, RAB31, PLD2, ASAP2, DNAJC6, PRKCZ, RAB11FIP5, RAB11A, EHD3, LDLRAP1, EGFR, HSPA6, AP2A1, PRKCI, SH3GLB2, PARD6B, ITCH, WWP1, PARD6G, RAB22A, AP2B1, TFRC, PSD, AP2S1, AP2M1, IQSEC1, ARRB1, PIKFYVE, VPS4A, EPN1, DNM1, VPS4B, ASAP1, RAB11B, NEDD4, PDCD6IP, HSPA1A, CHMP5, VPS45, CXCR4, SH3KBP1, RAB11FIP2, USP8, CBLB, EHD4, CLTC, SRC, ARF6, RBSN, CDC42, CHMP2A, EPN2, DNM2, RAB5B, RAB5C, ARFGAP1, ARFGAP3, VPS37B, STAMBP, RUFY1, EPS15, RAB4A",1.40560744962457,0.496209316942819,FALSE
+"H1650","Input","KEGG_ENDOMETRIAL_CANCER",0.38149,1.17,0.24,1393,0.467,"ERBB2, CTNNA1, CTNNB1, CTNNA2, APC, EGFR, MAPK3, AKT2, CDH1, AKT3, PIK3R3, SOS1",0.619788758288394,0.330683119433888,FALSE
+"H1650","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.27897,-0.865,0.588,6538,0.701,"ATP6V1B2, ATP6V0A2, PAK1, ATP6V1A, ATP6V1D, ATP6V1F, GIT1, MAPK8, ATP6V1G1, ATP6V1H, ATP6V1B1, IKBKB, JUN, JAM3",0.230622673923862,0.154281982033341,FALSE
+"H1650","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.22638,0.682,0.869,1393,0.927,"CAMK2G, ERBB4, CAMK2B, ERBB2, CAMK2D, PTK2, EGFR, GAB1, MAPK3, AKT2, AKT3, PIK3R3, SOS1",0.0609802235513335,0.0329202658555029,FALSE
+"H1650","Input","KEGG_ETHER_LIPID_METABOLISM",0.63829,1.94,0.019,1323,0.16,"PLPP3, PLD2, LPCAT2, LPCAT4, PAFAH2, PLPP1, LPCAT1",1.72124639904717,0.795880017344075,TRUE
+"H1650","Input","KEGG_FATTY_ACID_METABOLISM",0.28502,0.877,0.601,1307,0.725,"ACOX3, ALDH7A1, ACSL1, ACSL5, ACAA1, ACOX1, ACSL6, ALDH3A2",0.22112552799726,0.139661993429006,FALSE
+"H1650","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.2185,0.673,0.901,2710,0.931,"PRKCD, VAV2, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SOS1, PRKCE, MAPK14, LYN, PRKCA, MAPK13, PLCG2, RAC1, FYN, HRAS, AKT1, MAP2K6, PLA2G12A, PIK3CB",0.045275209020937,0.0310503190186574,FALSE
+"H1650","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3819,1.17,0.25,1661,0.467,"PLPP3, DNM3, ASAP3, PLD2, ASAP2, PRKCD, AMPH, VAV2, LIMK2, VASP, CFL2, PLPP1, MAPK3, GSN, PIKFYVE, AKT2, DNM1, AKT3, PIK3R3, SPHK2, ASAP1, PRKCE, LYN, ARPC1B, PRKCA",0.602059991327962,0.330683119433888,FALSE
+"H1650","Input","KEGG_FOCAL_ADHESION",0.38179,1.18,0.215,1958,0.466,"ITGA4, ITGA6, ITGA3, ITGB4, CAV2, CAV1, ITGA1, ITGB1, ARHGAP35, ERBB2, LAMA5, ITGA2, ITGA5, CAPN2, CTNNB1, ITGB5, FLNC, LAMA3, LAMA4, VAV2, PTK2, EGFR, ITGAV, LAMB1, VASP, ITGB8, MAPK3, COL5A1, AKT2, ACTN4, AKT3, PIK3R3, HGF, SOS1, PXN, MYL9, TNC, PRKCA, ROCK1, RAP1A, MYL12A, ACTG1, SRC, FLT4, CDC42",0.667561540084395,0.33161408331,FALSE
+"H1650","Input","KEGG_FOLATE_BIOSYNTHESIS",0.70452,2.17,0.0053,12,0.0964,"ALPI, ALPP",2.27572413039921,1.01592296609717,TRUE
+"H1650","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.25161,0.776,0.758,2497,0.834,"MPI, PFKFB4, AKR1B1, PFKP, PFKFB2, GMPPB, MTMR1, GMPPA, AKR1B10, HK1, PFKL, PMM2, ALDOA, PHPT1, HK2",0.120330794367946,0.0788339493622613,FALSE
+"H1650","Input","KEGG_GALACTOSE_METABOLISM",0.42858,1.35,0.131,998,0.356,"PGM1, B4GALT1, UGP2, GLB1, AKR1B1, PFKP",0.882728704344236,0.448550002027125,FALSE
+"H1650","Input","KEGG_GAP_JUNCTION",0.3026,0.923,0.535,2086,0.684,"PRKACB, ADCY6, ADCY5, TUBA4A, EGFR, ITPR2, GNAS, ADCY3, ADCY8, MAPK3, SOS1, PRKACA, PRKCA, GNAQ, CDK1, SRC, MAPK7, GNA11",0.271646217978772,0.164943898279884,FALSE
+"H1650","Input","KEGG_GLIOMA",-0.27733,-0.872,0.577,8588,0.705,"E2F3, CALM2, RB1, CALML3, TP53",0.238824186844269,0.151810883008601,FALSE
+"H1650","Input","KEGG_GLUTATHIONE_METABOLISM",-0.31026,-0.965,0.46,7811,0.654,"GPX4, GSTZ1, GCLC, GPX3, GSTM4, GSTM3, GPX2, GSTM2, GSTM1, GSTP1",0.337242168318426,0.184422251675733,FALSE
+"H1650","Input","KEGG_GLYCEROLIPID_METABOLISM",0.42595,1.3,0.178,1307,0.379,"PLPP3, MGLL, DGKA, CEL, ALDH7A1, MBOAT2, AKR1B1, AGPAT4, PLPP1, ALDH3A2",0.749579997691106,0.421360790031928,FALSE
+"H1650","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40271,1.24,0.183,1709,0.414,"PLPP3, PEMT, DGKA, MBOAT7, PLD2, LPCAT2, LPCAT3, LPCAT4, MBOAT2, PLA2G15, AGPAT4, PISD, PLPP1, LPCAT1, DGKB, CDS1, AGPAT2",0.737548910269571,0.382999658879101,FALSE
+"H1650","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.2957,-0.92,0.509,6701,0.683,"GLDC, CHDH, GAMT, SHMT2, PSPH, PIPOX, MAOA, CTH",0.293282217663241,0.165579296318467,FALSE
+"H1650","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.263,-0.81,0.664,7561,0.786,"PGK2, ADH4, ADH7, FBP2, ENO2, PCK2, FBP1, GCK, ALDH3A1, ALDOC, ADH1C, ALDH2, ALDH1B1",0.177831920631982,0.104577453960592,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.61807,1.9,0.019,2827,0.174,"B3GALT6, CHST14, CHSY1, XYLT2, B3GAT3, B4GALT7",1.72124639904717,0.7594507517174,TRUE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.3413,-1.07,0.373,8794,0.597,"HS6ST2",0.428291168191312,0.224025668870631,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66224,2.02,0.0182,1356,0.126,"B4GALT1, ST3GAL2, B4GALT4",1.73992861201493,0.899629454882437,TRUE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.53564,1.67,0.032,1663,0.303,"GALNS, ARSB, GLB1, HPSE, NAGLU, HEXA",1.49485002168009,0.518557371497695,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.56792,1.72,0.0366,1663,0.281,"ST3GAL2, GLB1, HEXA",1.43651891460559,0.55129368009492,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.69372,2.12,0.00887,2389,0.0816,"ST3GAL2, HEXA, FUT1, NAGA",2.05207638016827,1.08830984124614,TRUE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.56773,1.74,0.0504,1356,0.278,"B3GNT3, B4GALT1, ST3GAL4, FUT3, B4GALT4",1.29756946355447,0.555955204081924,FALSE
+"H1650","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.56312,1.74,0.0252,1311,0.278,"GPAA1, PIGT, PIGW, PIGS, PIGU, PIGK",1.59859945921846,0.555955204081924,FALSE
+"H1650","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.37042,1.13,0.27,2268,0.479,"MTHFD2, GRHPR, ACO2, MDH1",0.568636235841013,0.319664486585437,FALSE
+"H1650","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.40632,1.27,0.185,2086,0.389,"CAMK2G, CAMK2B, PTK2B, PRKACB, ADCY6, PLD2, ADCY5, PRKCD, CAMK2D, MMP2, EGFR, ITPR2, GNAS, MAPK12, ADCY3, ADCY8, MAPK3, SOS1, MAPK14, PRKACA, PRKCA, GNAQ, MAPK13, SRC, CDC42, MAPK7, GNA11",0.732828271596986,0.410050398674292,FALSE
+"H1650","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.24094,-0.739,0.763,8187,0.898,"SHH, FBXW11",0.11747546204512,0.0467236633326956,FALSE
+"H1650","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.702,2.15,0.0149,853,0.0898,"ITGA4, ANPEP, ITGA6, ITGA3, CD36, CD9, ITGA1, CD14, ITGA2, MME, ITGA5, CD59, CD55, KITLG",1.82681373158773,1.0467236633327,TRUE
+"H1650","Input","KEGG_HISTIDINE_METABOLISM",-0.51952,-1.58,0.0791,8386,0.329,"ALDH3A1, ALDH2, HNMT, ALDH1B1, MAOA, DDC",1.10182351650232,0.482804102050026,FALSE
+"H1650","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.39924,-1.28,0.195,5027,0.414,"TOP3A, MRE11, SSBP1, POLD3, RPA3, POLD2, RPA2, RPA1, TOP3B, RAD51, MUS81, BLM",0.709965388637482,0.382999658879101,FALSE
+"H1650","Input","KEGG_HUNTINGTONS_DISEASE",0.13224,0.408,0.998,1932,1,"TGM2, NDUFA2, DNAH2, CYC1, UQCR10, SDHD, AP2A1, AP2B1, AP2S1, AP2M1, VDAC2, CREBBP, SDHC, EP300, CYCS, GNAQ, COX6A1, CASP8, UQCRC2, CLTC, UQCRFS1",0.000869458712628891,0,FALSE
+"H1650","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.45307,1.4,0.107,731,0.366,"ITGA4, ITGA6, ITGA3, ITGB4, TPM2, ITGA1, ITGB1, ITGA2, ITGA5, SLC8A1, ITGB5, ACE, TPM1, DAG1",0.97061622231479,0.436518914605589,FALSE
+"H1650","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25755,0.78,0.715,3028,0.835,"INPP4B, MINPP1, PLCD1, IMPA2, ITPK1, PI4KA, PIKFYVE, PIK3C2B, ISYNA1, INPP5K, PLCG2, INPP4A, PIK3C3, INPP1, INPPL1, PIP4K2C, PIK3CB, INPP5A, PIK3CA, PIK3CD, SYNJ1, PLCD3",0.145693958198919,0.0783135245163979,FALSE
+"H1650","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.25849,0.788,0.708,1790,0.837,"PRKACB, PRKCZ, PRKAR1B, PHKB, PHKA1, PPP1R3D, PRKAR1A, PRKCI, FASN, GYS1, PTPRF, PKLR, MAPK3, AKT2, AKT3, PIK3R3, PTPN1, SOS1, PRKAA1, PPP1R3A, EXOC7, TRIP10, MTOR, ACACA, PRKACA, INPP5K, HK1, CBLB",0.149966742310231,0.07727454200674,FALSE
+"H1650","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27213,0.816,0.66,1790,0.802,"IFNGR1, STAT1, STAT2, IRF9, STAT3, AKT2, AKT3, PIK3R3, SOS1, CREBBP, EP300, EPO, CBLB",0.180456064458131,0.0958256317158365,FALSE
+"H1650","Input","KEGG_LEISHMANIA_INFECTION",0.49823,1.52,0.0591,1829,0.335,"ITGA4, TRAF6, IFNGR1, STAT1, ITGB2, ITGB1, C3, MYD88, MAPK12, MAPK3, MAP3K7, MAPK14, CR1, CYBA, MAPK13",1.22841251911874,0.474955192963155,FALSE
+"H1650","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.36077,1.13,0.267,1958,0.479,"ITGA4, CLDN6, ITGB2, CD99, ITGB1, CLDN4, ARHGAP35, PTK2B, F11R, CTNNA1, CTNNB1, OCLN, CTNND1, MMP2, CTNNA2, VAV2, PTK2, MAPK12, VASP, EZR, ACTN4, PIK3R3, PXN, MYL9, MAPK14, PRKCA, CXCR4, CYBA, ROCK1, RAP1A, MAPK13, MYL12A, ACTG1, MSN, CDC42",0.573488738635425,0.319664486585437,FALSE
+"H1650","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.4291,-1.34,0.145,8635,0.465,"ALDH2, ALDH1B1",0.838631997765025,0.332547047110046,FALSE
+"H1650","Input","KEGG_LONG_TERM_DEPRESSION",0.22147,0.692,0.883,2091,0.922,"GNAO1, ITPR2, GNAS, MAPK3, LYN, PRKCA, GNAQ, CACNA1A, GNA11, GNA12",0.0540392964224314,0.0352690789463706,FALSE
+"H1650","Input","KEGG_LONG_TERM_POTENTIATION",0.41177,1.25,0.212,1817,0.408,"CAMK2G, PPP3R2, CAMK2B, PPP3R1, PRKACB, PPP3CA, PPP3CB, CAMK2D, ITPR2, ADCY8, MAPK3, CREBBP, EP300, RPS6KA1, PRKACA, PRKCA, GNAQ, RAP1A",0.673664139071249,0.38933983691012,FALSE
+"H1650","Input","KEGG_LYSINE_DEGRADATION",-0.36126,-1.12,0.313,7926,0.574,"KMT5A, NSD2, SETMAR, KMT5C, PIPOX, SETDB2, NSD3, AASS, ALDH2, ALDH1B1",0.504455662453552,0.241088107602027,FALSE
+"H1650","Input","KEGG_LYSOSOME",0.48056,1.49,0.0807,1219,0.348,"GALC, AP1M2, CTSH, AP1S1, LIPA, GM2A, CTSL, CTSZ, AP1G1, CTSK, CTSO, GALNS, CTSV, ARSB, GGA2, LAMP3, PLA2G15, TCIRG1, GLB1, CTSA, ARSA, MANBA, AP1B1, NAPSA, CTSF, AP1S3",1.09312646527793,0.458420756053419,FALSE
+"H1650","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.33128,1.01,0.412,1661,0.606,"HSPA2, TRAF6, HSPA1L, HSPB1, CD14, PPP3R2, MAP3K5, TAOK3, PPP3R1, PRKACB, RRAS, PPP3CA, PPP3CB, TGFBR2, FLNC, MAP3K20, FGF13, FGF2, EGFR, MAPKAPK3, HSPA6, NFKB2, CDC25B, FAS, RASA1, MAPK12, MAPK8IP3, MAPK3, STK3, MAP3K7, ARRB1, AKT2, AKT3, SOS1, GNG12, HSPA1A, RPS6KA1, MAPK14, PRKACA, PRKCA",0.385102783966865,0.217527375833714,FALSE
+"H1650","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.48931,-1.53,0.0732,6087,0.331,"HNF1A, HNF4A, PDX1, HES1, GCK, FOXA2",1.13548891894161,0.480172006224281,FALSE
+"H1650","Input","KEGG_MELANOGENESIS",0.44204,1.37,0.136,1687,0.358,"CAMK2G, GNAO1, CAMK2B, FZD2, PRKACB, ADCY6, FZD1, CTNNB1, ADCY5, CAMK2D, KITLG, GNAS, ADCY3, ADCY8, MAPK3, CREBBP, EP300, PRKACA, PRKCA, GNAQ",0.866461091629782,0.446116973356126,FALSE
+"H1650","Input","KEGG_MELANOMA",0.23353,0.718,0.843,1392,0.916,"FGF13, FGF2, EGFR, MAPK3, AKT2, CDH1, AKT3, PIK3R3, HGF",0.0741724253752577,0.0381045263321496,FALSE
+"H1650","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.54792,-1.69,0.0407,7630,0.31,"ADH4, ADH7, GSTZ1, ALDH3A1, GSTM4, ADH1C, AKR1C2, AKR1C1, GSTM3, AKR1C3, GSTM2, GSTM1, GSTP1",1.39040559077478,0.508638306165727,FALSE
+"H1650","Input","KEGG_MISMATCH_REPAIR",-0.40526,-1.29,0.181,5305,0.42,"SSBP1, POLD3, RFC2, RFC3, RFC5, RPA3, POLD2, RPA2, RPA1, MSH2, RFC1, MSH6, RFC4",0.742321425130815,0.3767507096021,FALSE
+"H1650","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.30813,0.965,0.442,3004,0.65,"MAPK3, AKT2, AKT3, PIK3R3, PRKAA1, CAB39, RICTOR, RPS6KA1, MTOR, RPTOR, TSC2, AKT1, RPS6KA3, RHEB, PIK3CB, PIK3CA, RPS6KA6, PIK3CD, RPS6KA2, PDPK1",0.354577730650908,0.187086643357144,FALSE
+"H1650","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.4509,1.37,0.122,1393,0.358,"IFNGR1, ITGB2, RAET1L, ULBP2, PPP3R2, NFAT5, PTK2B, PPP3R1, PPP3CA, PPP3CB, VAV2, FAS, MAPK3, PIK3R3, SOS1",0.913640169325252,0.446116973356126,FALSE
+"H1650","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.34133,-1.05,0.364,7011,0.614,"PARD3, P2RY11, GRIN1, CHRM3, CGA, LTB4R2, F2",0.438898616350944,0.211831628858832,FALSE
+"H1650","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.21656,0.67,0.892,2954,0.927,"TRAF6, CAMK2G, CAMK2B, MAP3K5, ARHGDIB, PRKCD, CAMK2D, SH2B1, YWHAZ, GAB1, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SOS1, RPS6KA1, MAPK14, YWHAB, RAP1A, MAPK13, CDC42, MAPK7, PLCG2, NFKB1, RAC1, YWHAE, HRAS, MAPKAPK2, MAP3K3, AKT1, RPS6KA3, RIPK2, PIK3CB, RHOA, BCL2, RPS6KA4, IRS1, PIK3CA, RPS6KA6, MAGED1, PIK3CD, RPS6KA2",0.0496351456238769,0.0329202658555029,FALSE
+"H1650","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.44745,1.35,0.128,205,0.356,"NNMT, QPRT, BST1",0.892790030352132,0.448550002027125,FALSE
+"H1650","Input","KEGG_NITROGEN_METABOLISM",-0.4414,-1.36,0.133,7821,0.466,"GLUD2, CPS1, CA14, CA1, ASNS, CTH, CA8",0.876148359032914,0.33161408331,FALSE
+"H1650","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37018,1.12,0.293,1987,0.488,"TRAF6, CASP1, IL18, NAIP, MAPK12, MAPK3, MAP3K7, MAPK14, CASP8, CASP5, MAPK13, CHUK, PYCARD",0.533132379645891,0.311580177997289,FALSE
+"H1650","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.46852,-1.44,0.114,4762,0.413,"NHEJ1, MRE11, PRKDC, XRCC4, POLM, FEN1",0.943095148663527,0.384049948343599,FALSE
+"H1650","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.30704,-0.947,0.487,8588,0.652,"E2F3, RB1, FOXO3, FHIT, TP53",0.312471038785366,0.18575240426808,FALSE
+"H1650","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.22704,-0.709,0.827,7053,0.911,"HES1, SNW1, LFNG, KAT2A, CTBP1, DLL3, HDAC2, JAG1",0.0824944904474534,0.0404816230270017,FALSE
+"H1650","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.42132,-1.3,0.182,5584,0.427,"RFC3, RFC5, RPA3, POLD2, XPC, RPA2, RPA1, CCNH, ERCC8, RFC1, CDK7, RFC4, POLE3, ERCC6, ERCC3, GTF2H5, CUL4A, GTF2H3, GTF2H4, GTF2H2, GTF2H1, MNAT1, ERCC5",0.739928612014925,0.369572124974976,FALSE
+"H1650","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.33445,1.05,0.325,2219,0.55,"B4GALT1, MAN2A2, MAN1B1, MAN2A1, TUSC3, STT3B, ALG2, MGAT1, DPM1, GANAB, MAN1A2, RFT1, DDOST",0.488116639021126,0.259637310505756,FALSE
+"H1650","Input","KEGG_OLFACTORY_TRANSDUCTION",0.36076,1.08,0.312,668,0.515,"CAMK2G, CAMK2B, PRKACB, CAMK2D",0.505845405981557,0.288192770958809,FALSE
+"H1650","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.22552,-0.683,0.827,5223,0.932,"TYMS, ATIC, MTHFD1L, MTR, MTFMT, SHMT2",0.0824944904474534,0.0305840876460186,FALSE
+"H1650","Input","KEGG_OOCYTE_MEIOSIS",0.41873,1.28,0.158,1812,0.383,"CAMK2G, PPP3R2, CAMK2B, PPP3R1, PRKACB, ADCY6, PPP3CA, PPP3CB, ADCY5, CAMK2D, AR, ITPR2, PPP2R5E, YWHAZ, MAPK12, ADCY3, ADCY8, PLK1, MAPK3, SKP1, RPS6KA1, PRKACA, PPP2R5A, CDK1, YWHAB",0.801342913045577,0.416801226031377,FALSE
+"H1650","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.35693,1.08,0.323,1663,0.515,"GLB1, MANBA, MAN2B2, HEXA",0.490797477668897,0.288192770958809,FALSE
+"H1650","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.13403,0.408,1,2760,1,"NDUFA2, CYC1, UQCR10, LHPP, TCIRG1, SDHD, COX15, SDHC, COX6A1, ATP12A, ATP6V1C2, UQCRC2, UQCRFS1, SDHB, ATP6V1C1, UQCRC1, NDUFA3, UQCRQ, SDHA, COX17, COX6B1, COX7A2, COX7A2L, COX4I1, NDUFA4, UQCRH",0,0,FALSE
+"H1650","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.81624,2.48,0,683,0.0195,"GALNT6, C1GALT1, C1GALT1C1, GALNT14, GALNT15, GALNT10, GALNT13, GALNT7, GALNT3, GALNT12, GALNT2, ST3GAL2, B4GALT5",Inf,1.70996538863748,TRUE
+"H1650","Input","KEGG_P53_SIGNALING_PATHWAY",0.44078,1.34,0.15,1793,0.36,"TP53I3, SERPINB5, CD82, EI24, RRM2, DDB2, FAS, RRM2B, SFN, IGFBP3, CYCS, CHEK2, CASP8, CDK1",0.823908740944319,0.443697499232713,FALSE
+"H1650","Input","KEGG_PANCREATIC_CANCER",0.2311,0.712,0.846,2235,0.909,"STAT1, ERBB2, TGFBR2, EGFR, SMAD3, RALA, STAT3, MAPK3, AKT2, AKT3, PIK3R3, RALB, CDC42, JAK1, CHUK, SMAD2, NFKB1, RAC1",0.0726296369609765,0.0414361167780325,FALSE
+"H1650","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3653,1.14,0.253,1470,0.491,"PPCS, BCAT2, PANK4",0.596879478824182,0.308918507877032,FALSE
+"H1650","Input","KEGG_PARKINSONS_DISEASE",0.19018,0.579,0.968,837,0.985,"UBE2L6, UBA7, NDUFA2, CYC1, UQCR10, SDHD",0.0141246426916063,0.00656376950238827,FALSE
+"H1650","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.31159,0.96,0.459,1958,0.652,"ITGB1, CD14, CTNNB1, OCLN, TUBA4A, YWHAZ, CDH1, EZR, ARPC1B, PRKCA, ROCK1, ACTG1, CDC42",0.338187314462739,0.18575240426808,FALSE
+"H1650","Input","KEGG_PATHWAYS_IN_CANCER",0.27649,0.847,0.635,1661,0.766,"TRAF6, ITGA6, STAT1, ITGA3, ITGB1, ERBB2, LAMA5, ITGA2, FZD2, RXRA, FZD1, CTNNA1, CTNNB1, SLC2A1, TGFBR2, MMP2, LAMA3, LAMA4, CTNNA2, APC, FGF13, FGF2, KITLG, AR, PTK2, EGFR, NFKB2, ITGAV, FAS, LAMB1, SMAD3, RARA, RALA, STAT3, MAPK3, AKT2, CDH1, AKT3, PIK3R3, HGF, SOS1, DAPK1, CKS1B, CREBBP, FLT3, EP300, MTOR, CYCS, PRKCA",0.197226274708024,0.115771230367396,FALSE
+"H1650","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.42783,-1.32,0.168,8393,0.467,"UGDH, CRYL1",0.774690718274137,0.330683119433888,FALSE
+"H1650","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.27629,0.829,0.654,998,0.793,"PGM1, RBKS, H6PD, PFKP",0.184422251675733,0.100726812682396,FALSE
+"H1650","Input","KEGG_PEROXISOME",0.48695,1.5,0.0873,2573,0.348,"PXMP4, ACOX3, SLC25A17, DECR2, MVK, ECH1, ACSL1, ACSL5, ACOT8, ACAA1, ABCD1, CROT, DAO, AMACR, ACOX1, GSTK1, HACL1, ACSL6, PEX13, HSD17B4, ABCD3, CAT, CRAT, PXMP2, PEX3, PEX14, PEX11A, AGPS, SCP2, ECI2, IDH1, PRDX1, EHHADH, ACSL3, PRDX5, NUDT19, PEX26, IDH2",1.05898575629443,0.458420756053419,FALSE
+"H1650","Input","KEGG_PHENYLALANINE_METABOLISM",-0.59458,-1.82,0.0289,8386,0.498,"ALDH3A1, MAOA, DDC",1.53910215724345,0.302770657240282,FALSE
+"H1650","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25482,0.785,0.712,1672,0.835,"INPP4B, DGKA, PLCD1, IMPA2, ITPR2, ITPK1, PI4KA, PIKFYVE, PIK3R3, PIK3C2B, DGKB, CDS1, PRKCA, INPP5K",0.147520006363144,0.0783135245163979,FALSE
+"H1650","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.53052,1.6,0.0613,1730,0.32,"CP, EARS2, FTH1, BLVRB, COX15, HCCS, HMOX1, UROS, FECH",1.21253952548158,0.494850021680094,FALSE
+"H1650","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.39589,1.23,0.198,1093,0.407,"SCD5, CD36, SLC27A6, ACOX3, FADS2, SCD, RXRA, ACSL1, ACSL5, SLC27A4, ACAA1, ACOX1, ACSL6",0.703334809738469,0.39040559077478,FALSE
+"H1650","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.41756,1.29,0.149,1109,0.385,"CYP7B1, AMACR, HSD17B4",0.826813731587726,0.414539270491499,FALSE
+"H1650","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.52972,1.63,0.0531,1156,0.299,"CD40, TAP1, TAP2, ADA",1.27490547891853,0.52432881167557,FALSE
+"H1650","Input","KEGG_PRION_DISEASES",-0.32333,-1.01,0.406,8618,0.627,"C9, NCAM1",0.391473966422806,0.202732459169284,FALSE
+"H1650","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.40222,1.21,0.22,1829,0.428,"PRKACB, ADCY6, ADCY5, CDC25B, MAPK12, ADCY3, ADCY8, PLK1, MAPK3, AKT2, FZR1, AKT3, PIK3R3, RPS6KA1, MAPK14, PRKACA, CDK1, MAPK13",0.657577319177794,0.368556230986828,FALSE
+"H1650","Input","KEGG_PROPANOATE_METABOLISM",-0.28258,-0.878,0.53,8180,0.71,"ACSS3, PCCB, ALDH6A1, PCCA, ALDH2, ALDH1B1",0.275724130399211,0.148741651280925,FALSE
+"H1650","Input","KEGG_PROSTATE_CANCER",-0.31824,-0.976,0.452,8368,0.652,"IKBKB, E2F3, RB1, TP53, GSTP1, CDKN1B",0.344861565188618,0.18575240426808,FALSE
+"H1650","Input","KEGG_PROTEASOME",0.31048,0.967,0.465,263,0.654,"PSMB10, PSMB9",0.332547047110046,0.184422251675733,FALSE
+"H1650","Input","KEGG_PROTEIN_EXPORT",-0.16757,-0.505,0.995,1481,0.992,"SEC62, SRP19, SRP54, SRPRA, SRP68, SRP72, SPCS1, HSPA5, SPCS3, SRPRB, SPCS2, SEC11A, OXA1L, IMMP1L, SEC61B, SRP14, SEC61A1, SRP9, SEC63, SEC11C",0.00217691925427455,0.00348832784582135,FALSE
+"H1650","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.43619,1.31,0.14,2268,0.373,"GLS, GLS2, ATP1B3, ATP1B1, ATP1A3, ATP1A1, ATP1A4, CA2, MDH1",0.853871964321762,0.428291168191312,FALSE
+"H1650","Input","KEGG_PURINE_METABOLISM",-0.22859,-0.717,0.81,5972,0.917,"APRT, POLR3F, GMPS, POLR1B, POLR1A, POLR2I, PRPS1, PRPS1L1, POLR3H, POLR3G, POLR2D, POLR1E, NME2, PDE6D, GUK1, POLR3C, ITPA, PRIM1, POLR2C, POLR2H, NUDT2, POLA1, POLR2L, PNP, PFAS, AK2, POLR2E, NME7, POLE3, AK1, NT5C, PRIM2, NUDT5, NME1, AK5, POLA2, GMPR2, PDE3A, PDE4A, PDE1C, POLR1C, POLR1D, GMPR, XDH, IMPDH1, NPR2, FHIT",0.0915149811213502,0.0376306643299789,FALSE
+"H1650","Input","KEGG_PYRIMIDINE_METABOLISM",0.19702,0.616,0.954,1078,0.976,"CDA, CMPK2, NME3, TYMP, RRM2, NME4, TK1, TK2, DHODH, RRM2B",0.0204516252959049,0.0105501823333082,FALSE
+"H1650","Input","KEGG_PYRUVATE_METABOLISM",0.23467,0.708,0.83,2433,0.907,"ALDH7A1, ACSS2, AKR1B1, ME3, PKLR, ALDH3A2, PC, ACACA, GRHPR, ACAT2, ACSS1, ACACB, MDH1, DLD, ME2",0.0809219076239261,0.0423927129399047,FALSE
+"H1650","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.40176,1.23,0.201,1645,0.407,"ITGA4, ITGA6, ITGA3, ITGB4, ITGB2, ITGA1, ITGB1, CD14, MYH14, ARHGAP35, ITGA2, ITGA5, RDX, RRAS, TIAM1, ITGB5, FGD3, APC, FGF13, FGF2, VAV2, PTK2, EGFR, SLC9A1, ITGAV, LIMK2, CFL2, MYH9, ITGB8, TIAM2, MAPK3, GSN, PIKFYVE, BAIAP2, EZR, ACTN4, PIK3R3, SOS1, PXN, GNG12, MYL9, ARPC1B, CYFIP2, NCKAP1",0.696803942579511,0.39040559077478,FALSE
+"H1650","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.28536,0.868,0.61,2369,0.735,"GABARAPL2, GABARAPL1, PRKAA1, PIK3R4, ATG4B, ATG4A, PIK3C3",0.214670164989233,0.133712660915805,FALSE
+"H1650","Input","KEGG_RENAL_CELL_CARCINOMA",0.22774,0.715,0.826,3477,0.912,"SLC2A1, GAB1, MAPK3, AKT2, AKT3, PIK3R3, HGF, SOS1, CREBBP, EP300, RAP1A, CDC42, RAC1, HRAS, PAK5, PAK6, AKT1, CUL2, PAK4, PIK3CB, PIK3CA, PIK3CD, ELOB, CRKL, PIK3R2, RBX1, MAPK1, MAP2K1, FLCN, PAK2, KRAS, NRAS",0.0830199526796178,0.0400051616715838,FALSE
+"H1650","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.6738,2.12,0.00742,843,0.0816,"CPA3, ANPEP, MME, ACE, CTSA",2.12959609472097,1.08830984124614,TRUE
+"H1650","Input","KEGG_RETINOL_METABOLISM",-0.33223,-1.04,0.344,7630,0.613,"ADH4, ADH7, ADH1C, ALDH1A1, ALDH1A2",0.46344155742847,0.212539525481585,FALSE
+"H1650","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.32563,-1.03,0.389,5705,0.612,"ACP1, FLAD1, TYR, MTMR6, ACP5, RFK",0.410050398674292,0.213248577854439,FALSE
+"H1650","Input","KEGG_RIBOSOME",-0.37685,-1.17,0.241,4360,0.512,"RPS2, RPS19, RPL3, RPL23, RPL21, RPS17, RPL7A, RPL9, RPS9, RPSA, RPL17, MRPL13, RPL13, RPL6, RPS13, RPLP2, RPS5, RPS7, RPL31, RPL4, RPL32, RPL19, RPL22, RPL27A, RPS29, RPS27A, RPL29, RPLP1, RPS25, RPS28, UBA52, RPS27L, RPS20, FAU, RPS11, RPS12, RPS10, RPL24, RSL24D1, RPL36A, RPL36AL, RPS21, RPS6, RPS23, RPL38, RPL37, RPL22L1",0.617982957425132,0.290730039024169,FALSE
+"H1650","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.46886,1.45,0.108,2213,0.343,"TRAF6, DDX58, ISG15, PIN1, IRF3, TRADD, CYLD, MAPK12, TRIM25, MAP3K7, MAPK14, CASP8, TKFC, MAPK13, CASP10, CHUK, TBK1, NFKB1",0.96657624451305,0.464705879957229,FALSE
+"H1650","Input","KEGG_RNA_DEGRADATION",-0.28274,-0.897,0.55,5355,0.692,"EXOSC6, XRN2, DCP2, EXOSC9, EXOSC10, EXOSC5, LSM6, DIS3, LSM8, EDC3, EXOSC8, EXOSC1, MPHOSPH6, EXOSC4, LSM1, PAPOLG, HSPD1, LSM2, DDX6, CNOT2, LSM7, ENO2, LSM4, DCP1B",0.259637310505756,0.159893905543242,FALSE
+"H1650","Input","KEGG_RNA_POLYMERASE",-0.53795,-1.64,0.0554,5344,0.294,"POLR3D, POLR2G, POLR3K, POLR3GL, POLR2J, POLR3F, POLR1B, POLR1A, POLR2I, POLR3H, POLR3G, POLR2D, POLR1E, POLR3C, POLR2C, POLR2H, POLR2L, POLR2E, POLR1C, POLR1D",1.25649023527157,0.531652669587843,FALSE
+"H1650","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.36514,1.13,0.257,123,0.479,"GGT1, PAPSS2",0.590066876668705,0.319664486585437,FALSE
+"H1650","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.29059,-0.904,0.559,8190,0.696,"FN1, LAMA1, IKBKB, E2F3, RB1, PTGS2, FHIT, TP53, MYC, ITGA2B, CDKN1B",0.252588192113577,0.157390760389438,FALSE
+"H1650","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.28169,0.881,0.564,2752,0.724,"VAMP8, BET1L, YKT6, STX16, VAMP3, STX4, GOSR1, STX8, VAMP2, SNAP47, VAMP4, STX10",0.248720896016658,0.140261433802853,FALSE
+"H1650","Input","KEGG_SPHINGOLIPID_METABOLISM",0.54486,1.68,0.0334,1396,0.31,"PLPP3, GALC, SPTLC2, GLB1, ARSA, DEGS1, SPTLC1, PLPP1, SPHK2",1.47625353318844,0.508638306165727,FALSE
+"H1650","Input","KEGG_SPLICEOSOME",-0.39623,-1.24,0.21,5458,0.449,"DHX15, PRPF31, SRSF10, ALYREF, EFTUD2, SRSF5, PRPF4, PHF5A, HNRNPK, SF3B6, EIF4A3, U2AF2, TRA2A, LSM6, RBMX, NCBP1, PLRG1, SRSF4, SF3B4, SMNDC1, HSPA8, U2SURP, CDC5L, LSM8, SNRPG, MAGOHB, DHX16, RBM25, SF3A1, PPIH, U2AF1, CHERP, PRPF19, ISY1, RBM22, SF3A2, SF3B3, PRPF18, SF3B2, RBM8A, SYF2, ZMAT2, HNRNPC, SNRPC, BCAS2, CRNKL1, NCBP2, PRPF40A, SRSF1, TCERG1, PPIE, TRA2B, PPIL1, SNW1, SRSF3, CDC40, BUD31, LSM2, SLU7, TXNL4A, LSM7, SNRNP40, DDX5, RBM17, SRSF2, SNRNP27, HNRNPM, SRSF8, HNRNPU, SART1, WBP11, PQBP1, HNRNPA3, CCDC12, ACIN1, HNRNPA1, CWC15, LSM4, SNU13",0.677780705266081,0.347753658996677,FALSE
+"H1650","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.31163,0.959,0.465,1077,0.646,"PGM1, SI, UGP2, GYS1",0.332547047110046,0.189767482004916,FALSE
+"H1650","Input","KEGG_STEROID_BIOSYNTHESIS",0.47462,1.46,0.081,759,0.351,"CEL, LIPA, DHCR24, SQLE, MSMO1",1.09151498112135,0.454692883534176,FALSE
+"H1650","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.55675,-1.73,0.0311,8521,0.356,"HSD11B2, AKR1D1, AKR1C2, AKR1C1, AKR1C3, HSD17B8",1.50723961097316,0.448550002027125,FALSE
+"H1650","Input","KEGG_SULFUR_METABOLISM",0.89874,2.66,0,196,0.00879,"SULT1A3, SULT2B1, PAPSS2, SULT1A1",Inf,2.05601112492623,TRUE
+"H1650","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.47555,1.41,0.102,1378,0.362,"CD40, C3, TRIM21, ACTN4",0.991399828238082,0.441291429466834,FALSE
+"H1650","Input","KEGG_TASTE_TRANSDUCTION",0.70438,2.19,0.00556,2081,0.109,"PRKACB, ADCY6, GNAS, ADCY8, PRKACA, CACNA1A",2.25492520841794,0.962573502059376,TRUE
+"H1650","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.34493,1.05,0.355,2017,0.55,"MVK, MVD, HMGCR, ACAT2, HMGCS1",0.449771646944906,0.259637310505756,FALSE
+"H1650","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21329,-0.67,0.909,6297,0.931,"SP1, INHBE, AMH, RPS6KB2, SMURF2, ACVR1, CHRD, TGFB2, TGFB3, TGFBR1, TFDP1, SMAD5, MYC",0.0414361167780325,0.0310503190186574,FALSE
+"H1650","Input","KEGG_THYROID_CANCER",-0.319,-1,0.427,8756,0.626,"TP53, MYC",0.369572124974976,0.20342566678957,FALSE
+"H1650","Input","KEGG_TIGHT_JUNCTION",0.41238,1.28,0.16,1993,0.383,"CLDN6, EPB41L1, MYH14, MYH7B, CLDN4, MYH4, PRKCQ, RRAS, F11R, CTNNA1, CTNNB1, OCLN, PRKCD, PRKCZ, MAP3K20, CTNNA2, TJP3, PRKCI, PARD6B, LLGL2, PARD6G, MYH11, CGN, MYH9, CASK, AKT2, VAPA, ACTN4, AKT3, MYH3, PRKCE, TJP2, MAGI3, EXOC3, MYL9, PRKCA, AMOTL1, MYL12A, ACTG1, SRC, CDC42, EXOC4",0.795880017344075,0.416801226031377,FALSE
+"H1650","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45925,1.43,0.112,2235,0.358,"CD40, TRAF6, STAT1, CD14, CTSK, IRF3, MYD88, TICAM2, MAPK12, TLR9, MAPK3, MAP3K7, AKT2, AKT3, PIK3R3, MAPK14, CASP8, MAPK13, CHUK, TBK1, NFKB1, RAC1",0.950781977329818,0.446116973356126,FALSE
+"H1650","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.34755,-1.07,0.311,8197,0.597,"HAAO, WARS2, ALDH2, ALDH1B1, MAOA, DDC",0.507239610973163,0.224025668870631,FALSE
+"H1650","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29609,0.915,0.539,1750,0.692,"PRKCD, PRKCZ, ABCC8, PKLR, MAPK3, PIK3R3, PRKCE, MTOR, HK1",0.268411234813261,0.159893905543242,FALSE
+"H1650","Input","KEGG_TYROSINE_METABOLISM",-0.61024,-1.88,0.0226,7263,1,"BUD23, METTL2B, ADH4, ADH7, TYRP1, GSTZ1, FAH, ALDH3A1, DCT, ADH1C, MAOA, DDC",1.6458915608526,0,FALSE
+"H1650","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3151,0.958,0.456,2728,0.641,"PPP3R2, NFAT5, PRKCQ, MALT1, PPP3R1, PPP3CA, PPP3CB, VAV2, MAPK12, MAPK3, MAP3K7, AKT2, AKT3, PIK3R3, SOS1, MAPK14, CBLB, MAPK13, CDC42, CHUK, NFKB1, FYN, HRAS, PAK5, PAK6, AKT1, CHP1, PAK4, PIK3CB, BCL10, RHOA, PTPN6",0.341035157335565,0.193141970481183,FALSE
+"H1650","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.30281,0.926,0.541,1790,0.686,"UBE2L6, TRAF6, UBA7, FBXO2, KEAP1, WWP2, FBXO4, UBE3B, DDB2, HERC4, ITCH, WWP1, HUWE1, FZR1, SYVN1, NEDD4, MID1, SKP1, TRIM32, SKP2, CBLB",0.266802734893431,0.163675884293248,FALSE
+"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.33149,0.986,0.445,5924,0.626,"BCAT2, IARS2, LARS2, BCAT1, PDHB, PDHA1, VARS2",0.351639989019068,0.20342566678957,FALSE
+"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30165,0.902,0.531,2929,0.701,"ABAT, ALDH7A1, ACAA1, HIBADH, ALDH3A2, BCAT2, OXCT1, ACAT2, HMGCS1, AUH, ACAD8, DLD, EHHADH, BCKDHB, MCCC2, HADH, HADHA, HADHB, ALDH9A1, ACADSB, MCCC1, MCEE",0.274905478918531,0.154281982033341,FALSE
+"H1650","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.34902,1.08,0.314,1760,0.515,"KCNMA1, PRKCQ, PRKACB, ADCY6, ADCY5, PRKCD, ITPR2, GNAS, MYL6, MYH11, ADCY3, ADCY8, MAPK3, PRKCE, MYL9, PRKACA, PRKCA, PPP1R12B, GNAQ, ROCK1",0.503070351926785,0.288192770958809,FALSE
+"H1650","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.50687,1.54,0.0745,2693,0.337,"PRKACB, ARHGDIB, ADCY6, RAB11A, GNAS, DYNC1LI2, ADCY3, RAB11B, DYNC1I2, DYNC1H1, PRKACA, STX4, RAB5B, RAB5C, DYNC2H1, DCTN1, RAB5A, VAMP2, DCTN4, DCTN6, DYNLL2",1.12784372725171,0.472370099128661,FALSE
+"H1650","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.44319,1.37,0.134,2710,0.358,"HSPB1, PPP3R2, NFAT5, PPP3R1, PPP3CA, PPP3CB, PTK2, MAPKAPK3, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SPHK2, PXN, MAPK14, PRKCA, MAPK13, SRC, CDC42, SH2D2A, PLCG2, RAC1, HRAS, MAPKAPK2, AKT1, PLA2G12A, CHP1, PIK3CB",0.872895201635192,0.446116973356126,FALSE
+"H1650","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.25989,0.806,0.696,2193,0.813,"PRKACB, ERO1A, KDELR3, TCIRG1, GNAS, ADCY3, TJP2, PRKACA, PRKCA, ATP6V1C2, ACTG1, PLCG2, ATP6V1C1",0.157390760389438,0.0899094544059319,FALSE
+"H1650","Input","KEGG_VIRAL_MYOCARDITIS",0.46071,1.45,0.0917,1185,0.343,"CD40, ITGB2, CAV1, MYH14, MYH7B, MYH4, CD55, DAG1, CXADR, MYH11, MYH9",1.03763066432998,0.464705879957229,FALSE
+"H1650","Input","KEGG_WNT_SIGNALING_PATHWAY",0.28828,0.91,0.53,1803,0.693,"CAMK2G, PPP3R2, CAMK2B, NFAT5, FZD2, PPP3R1, PRKACB, FZD1, PPP3CA, CTNNB1, PPP3CB, CAMK2D, APC, PPP2R5E, SMAD3, MAP3K7, PORCN, CREBBP, SKP1, EP300, PRKACA, PRKCA, PPP2R5A, ROCK1, VANGL1",0.275724130399211,0.159266765388193,FALSE
+"H1975","Input","KEGG_ABC_TRANSPORTERS",0.3515,1.06,0.342,1220,0.596,"ABCG2, ABCA3, TAP1, ABCB8, ABCA1",0.465973893943865,0.224753740259764,FALSE
+"H1975","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36108,1.09,0.315,2283,0.587,"MYC, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, STAT5A, RPS6KB2, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, RUNX1, TCF7L1, NFKB1, BRAF",0.501689446210399,0.231361898752386,FALSE
+"H1975","Input","KEGG_ADHERENS_JUNCTION",0.18147,0.547,0.981,2134,1,"RAC2, SORBS1, WASF1, ACTN3, FER, VCL, ACTN1, MAP3K7, FYN, MAPK1, SMAD4, TGFBR1, TCF7L1",0.0083309926200515,0,FALSE
+"H1975","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.31622,-0.969,0.447,8785,0.71,"PCK2, RXRB, PRKAB1, ACSL6, CPT1A, SLC2A1, ADIPOR2, ADIPOR1, PRKAA2",0.349692476868064,0.148741651280925,FALSE
+"H1975","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39596,1.2,0.238,1268,0.549,"GFPT2, ADSL, ASL, ASNS, ASS1, CPS1",0.623423042943488,0.260427655549908,FALSE
+"H1975","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.25709,0.774,0.762,2963,0.837,"PRKCA, PRKCB, PIK3R2, NR3C2, PIK3CA, MAPK1, IRS1, PDPK1, IRS2, SFN, NEDD4L, INSR",0.1180450286604,0.07727454200674,FALSE
+"H1975","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.62443,-1.9,0.0171,8351,0.246,"PLA2G12A, ACOX3, PLA2G2D, ACOX1, PLA2G4A, PLA2G2A",1.76700388960785,0.609064892896621,TRUE
+"H1975","Input","KEGG_ALZHEIMERS_DISEASE",-0.22158,-0.685,0.863,7249,0.909,"APOE, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, ADAM10, COX5B, BID, ATP5F1D, UQCRFS1, BAD, UQCRC2, COX5A, ATP5PF, NCSTN, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, PLCB2, APP, CYC1, ATP5PD, ATP2A2, UQCRB, CASP7, PLCB4, SNCA, BACE2, MME, PLCB1",0.0639892042847904,0.0414361167780325,FALSE
+"H1975","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.20376,0.609,0.953,7903,0.994,"LARS2, FARS2, HARS2, FARSB, FARSA, SEPSECS, CARS2, RARS2, TARS2, DARS2, MTFMT, YARS2, NARS2, VARS2, MARS2, PARS2, IARS2, EARS2, SARS2, WARS2, AARS2",0.0209070993616736,0.00261361560268669,FALSE
+"H1975","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.42705,1.3,0.158,2528,0.609,"GFPT2, RENBP, UAP1, AMDHD2, GMPPA, UGDH, GMPPB, HK2, GNPDA1, GPI, NAGK, GNE, PGM2, CYB5R3, HK3, PGM3",0.801342913045577,0.215382707367125,FALSE
+"H1975","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.48166,1.46,0.1,505,0.833,"NEFH, PRPH, PRPH2, TP53, NEFM, CCS",1,0.0793549985932124,FALSE
+"H1975","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.15472,0.461,0.998,2208,0.998,"CD74, TAP1, LGMN, CTSB, CTSL, HSPA2",0.000869458712628891,0.000869458712628891,FALSE
+"H1975","Input","KEGG_APOPTOSIS",0.47654,1.43,0.0954,2233,0.752,"TP53, IL1RAP, PRKACA, PRKAR1B, AKT1, CASP8, ENDOG, TRADD, PIK3R2, IRAK4, IRAK1, MYD88, TNFRSF10D, CAPN2, PIK3CA, IKBKG, PPP3CA, XIAP, CHUK, IKBKB, PRKAR1A, PPP3CB, IRAK2, PRKACB, PRKAR2A, FADD, ENDOD1, NFKB1",1.0204516252959,0.123782159408358,FALSE
+"H1975","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.40931,-1.24,0.191,8863,0.444,"PLA2G2D, TBXAS1, ALOX5, CYP2J2, CYP4F3, AKR1C3, PLA2G4A, PTGS2, PLA2G2A",0.718966632752272,0.35261702988538,FALSE
+"H1975","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34722,1.04,0.373,1902,0.59,"NOS3, MAOB, ASL, ARG1, ASS1, GATM, CPS1, CKB, MAOA, SMS, OAT, GLS, GLS2",0.428291168191312,0.229147988357856,FALSE
+"H1975","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.32182,-0.966,0.448,9580,0.68,"ITGA1, CACNA2D1, ITGB8, PKP2, CDH2, SGCD",0.348721986001856,0.167491087293764,FALSE
+"H1975","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32282,-0.998,0.399,7529,0.67,"ALDH7A1, ALDH3A2, ALDH2",0.399027104313252,0.173925197299174,FALSE
+"H1975","Input","KEGG_AXON_GUIDANCE",0.42478,1.28,0.188,1781,0.611,"RAC2, ABLIM3, SEMA3B, PAK5, PAK6, SRGAP1, DPYSL2, LIMK1, RGS3, EPHB2, SEMA7A, RASA1, PLXNA3, GNAI2, EPHB4, ABLIM1, NRP1, ROBO1, SRGAP2, SRGAP3, SEMA4C, PAK1, FYN, PPP3CA, MAPK1",0.72584215073632,0.213958789757446,FALSE
+"H1975","Input","KEGG_BASAL_CELL_CARCINOMA",0.41379,1.25,0.176,919,0.544,"FZD2, TP53, WNT5B, DVL1, DVL2",0.75448733218585,0.26440110030182,FALSE
+"H1975","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.18977,0.58,0.968,8043,1,"STON1, TAF11, GTF2E2, GTF2IRD1, GTF2E1, TAF1, TAF7, GTF2F1, TAF4, GTF2H3, GTF2A2, GTF2H4, TAF6L, GTF2H2, TAF2, TAF6, TBPL1, GTF2F2, TBP, TAF5, TAF5L, GTF2A1, TAF9, TAF9B, TAF10, GTF2B, GTF2I, TAF12, GTF2H1",0.0141246426916063,0,FALSE
+"H1975","Input","KEGG_BASE_EXCISION_REPAIR",-0.43785,-1.34,0.15,6637,0.416,"POLB, PCNA, PARP1, PARP2, MBD4, POLE3, MPG, XRCC1, LIG1, UNG, TDG, FEN1, POLD1, HMGB1, POLD3, MUTYH, POLE, POLD2, APEX2, POLE2",0.823908740944319,0.380906669373257,FALSE
+"H1975","Input","KEGG_BETA_ALANINE_METABOLISM",-0.2739,-0.849,0.611,7467,0.777,"ACADM, ALDH7A1, HADHA, ABAT, ALDH3A2, HIBCH, ALDH2",0.213958789757446,0.109578981199086,FALSE
+"H1975","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.24323,0.736,0.799,1537,0.886,"ACOT4, HACD2, HACD1, ACAA1",0.0974532206860086,0.0525662781129492,FALSE
+"H1975","Input","KEGG_BLADDER_CANCER",0.33074,1.01,0.391,2283,0.596,"TP53, MYC, THBS1, ARAF, TYMP, MAP2K2, RAF1, CDKN1A, MAPK1, VEGFA, DAPK3, CDK4, BRAF",0.407823242604133,0.224753740259764,FALSE
+"H1975","Input","KEGG_BUTANOATE_METABOLISM",-0.49108,-1.48,0.089,7529,0.38,"ALDH7A1, HADH, HADHA, ACADS, OXCT1, ABAT, ALDH3A2, HMGCS1, L2HGDH, ACAT2, ALDH2, BDH1, ALDH5A1",1.05060999335509,0.42021640338319,FALSE
+"H1975","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.37051,1.12,0.269,1904,0.589,"RAC2, CD79A, CARD11, CD81, VAV2, VAV1, AKT1, MALT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, PIK3CA, IKBKG, LYN, PPP3CA, MAPK1, CHUK, IKBKB, PPP3CB",0.570247719997592,0.229884705212898,FALSE
+"H1975","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.40289,1.2,0.215,2506,0.549,"NOS3, TNNC1, MYLK, PRKACA, PRKCA, CACNA1A, F2R, ITPR1, GNA15, ADCY7, PHKA1, PRKCB, PLCG2, GNA11, PHKB, CACNA1F, PTK2B, ATP2B1, PPP3CA, PPP3CB, ATP2A3, PRKACB, PHKG2, ITPR3, ATP2B2, ATP2B4, PLCD1, PHKA2, GNAS, CAMK2G, GRIN1",0.667561540084395,0.260427655549908,FALSE
+"H1975","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.31443,0.947,0.484,257,0.636,"MYH7, TNNC1, TPM4",0.315154638355588,0.196542884351586,FALSE
+"H1975","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.327,0.988,0.427,1763,0.606,"VCAN, ICAM2, CD274, SDC4, ICAM1, CD40, CNTNAP1, CLDN4, CADM1, MPZ, CDH15, CDH3, PVR, CLDN16, CLDN6, SPN, CD276, CLDN3, SDC1, ALCAM",0.369572124974976,0.217527375833714,FALSE
+"H1975","Input","KEGG_CELL_CYCLE",-0.37917,-1.15,0.248,7661,0.509,"ATR, ORC4, ANAPC7, ORC1, CDC25C, ORC2, CDC25B, CDC45, MCM2, MCM7, CDC26, RB1, RAD21, MCM4, MCM6, MCM3, ESPL1, DBF4, STAG1, TFDP2, PLK1, ORC3, ZBTB17, CDC7, E2F3, MAD2L1, TFDP1, MDM2, BUB1B, MAD2L2, CHEK1, TTK, BUB1, PTTG1, ORC6, TGFB1, CCNB2, WEE1, CDC20, SKP2, CCNA2, CDC14B",0.605548319173784,0.293282217663241,FALSE
+"H1975","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.28638,0.865,0.633,2283,0.701,"RAC2, PRKACA, GNG10, VAV2, VAV1, AKT1, ADCY7, PRKCB, RAF1, PIK3R2, GNAI2, BCAR1, PRKCD, GNB4, PTK2B, GRK2, PIK3CA, IKBKG, PAK1, STAT2, LYN, GNG5, HCK, MAPK1, CHUK, IKBKB, FOXO3, PRKACB, ARRB1, NFKB1, CRK, BRAF",0.198596289982645,0.154281982033341,FALSE
+"H1975","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.35431,1.07,0.346,2845,0.595,"TP53, MYC, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, CDKN1B, STAT5A, BCR, CDKN1A, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, SMAD4, TGFBR1, CDK4, RUNX1, NFKB1, CRK, BRAF, CRKL, TGFB2, CBL, SOS2, CCND1",0.460923901207223,0.22548303427145,FALSE
+"H1975","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.26691,-0.819,0.638,6745,0.802,"CLOCK, CSNK1E, BHLHE40",0.195179321278838,0.0958256317158365,FALSE
+"H1975","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.34781,-1.06,0.34,6653,0.59,"MDH2, OGDH, OGDHL, IDH3G, SDHB, DLST, IDH3B, IDH3A, PCK2, DLAT, IDH2",0.468521082957745,0.229147988357856,FALSE
+"H1975","Input","KEGG_COLORECTAL_CANCER",0.32619,0.987,0.421,2283,0.601,"RAC2, TP53, MYC, AKT1, ARAF, RAF1, PIK3R2, MAPK10, MAPK8, PIK3CA, APPL1, MAPK1, APC, SMAD4, TGFBR1, TCF7L1, BRAF",0.375717904164332,0.22112552799726,FALSE
+"H1975","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.38026,1.15,0.242,868,0.575,"SERPINE1, PROS1, C4A, PLAU, F2R, TFPI, A2M, C3",0.616184634019569,0.24033215531037,FALSE
+"H1975","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.38729,1.17,0.226,2745,0.56,"TAT, LDHA, CTH, SMS, LDHB, SDS, MPST, SRM, MTR, AHCY",0.645891560852599,0.2518119729938,FALSE
+"H1975","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.31713,-0.966,0.45,8918,0.68,"IL1R1, TNFSF13B, LIF, TGFB1, IL6, TNFRSF21, INHBA, CXCR4, TNFRSF11B, CX3CL1, CXCL5, NGFR",0.346787486224656,0.167491087293764,FALSE
+"H1975","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.25405,-0.772,0.719,9336,0.843,"TREX1, IL6, ZBP1",0.143271109617117,0.0741724253752577,FALSE
+"H1975","Input","KEGG_DILATED_CARDIOMYOPATHY",0.40717,1.25,0.191,257,0.544,"MYH7, TNNC1, ITGB3, DES, PRKACA, ITGA5, TPM4",0.718966632752272,0.26440110030182,FALSE
+"H1975","Input","KEGG_DNA_REPLICATION",-0.61634,-1.92,0.0224,7089,0.375,"RPA3, POLE3, MCM5, RNASEH2B, LIG1, RFC3, PRIM1, POLA1, MCM2, FEN1, POLD1, MCM7, POLD3, POLA2, RFC4, MCM4, MCM6, MCM3, POLE, POLD2, RNASEH2C, PRIM2, POLE2",1.64975198166584,0.425968732272281,FALSE
+"H1975","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.15728,0.471,0.998,2797,1,"ETS1, MAPK1, SPIRE1, SOS2",0.000869458712628891,0,FALSE
+"H1975","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47746,1.42,0.112,895,0.733,"ALDH3B1, MAOB, GSTP1, GSTA5, GSTM2, CYP3A4, GSTZ1",0.950781977329818,0.134896025358872,FALSE
+"H1975","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.48953,1.49,0.0718,1671,0.813,"UPP1, CDA, IMPDH1, CYP3A4, TYMP, UCKL1, DPYD, IMPDH2",1.1438755557577,0.0899094544059319,FALSE
+"H1975","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.41838,1.3,0.158,580,0.609,"FN1, COL5A1, TNC, ITGB3, COL1A2, ITGA5, THBS2, CD44, SDC4, COL6A1, THBS1, COL1A1",0.801342913045577,0.215382707367125,FALSE
+"H1975","Input","KEGG_ENDOCYTOSIS",0.31138,0.925,0.495,3371,0.633,"EHD2, SH3KBP1, ASAP3, F2R, EPN1, CHMP2A, RAB31, ITCH, IQSEC2, SH3GL1, RABEP1, EHD4, PSD3, DNM2, SMURF1, ASAP2, PLD2, STAM, ARFGAP1, ARFGAP3, IQSEC1, RBSN, GRK2, RAB11FIP5, PDCD6IP, GIT2, RAB5B, DNM1, CHMP3, ACAP2, DNAJC6, VPS37A, DNM1L, VPS4A, SH3GLB1, HSPA2, ARRB1, EEA1, AGAP1, PSD4, CHMP2B, PSD, RAB5A, SMURF2, CBL, ASAP1, RAB11FIP1, RAB11FIP2, WWP1, TSG101, PLD1, NEDD4L, STAM2, RAB22A, VPS4B, RAB5C, RNF41, GIT1, TRAF6, VPS25, ARF6, EPN3, EHD3",0.305394801066431,0.198596289982645,FALSE
+"H1975","Input","KEGG_ENDOMETRIAL_CANCER",0.41013,1.23,0.224,2283,0.542,"TP53, MYC, PTEN, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, PIK3CA, ILK, MAPK1, FOXO3, APC, TCF7L1, PDPK1, BRAF",0.649751981665837,0.266000713461613,FALSE
+"H1975","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.35618,1.09,0.307,3667,0.587,"PLCG2, MAPK10, MAPK8, MAP2K4, IKBKG, PAK1, LYN, CHUK, IKBKB, ATP6V1C1, NFKB1, ATP6V1G1, ATP6V1D, ATP6V1E1, ATP6V1B2, TCIRG1, MAPK14, ATP6V1B1, MAPK9, GIT1, ATP6V1H, PLCG1, RELA, CASP3, ATP6V1F, TJP1, ADAM17, ATP6V1A",0.512861624522813,0.231361898752386,FALSE
+"H1975","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.41338,1.27,0.183,2804,0.548,"PAK5, PAK6, PRKCA, MYC, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, CDKN1B, STAT5A, MAPK10, RPS6KB2, MAPK8, CDKN1A, MAP2K4, PIK3CA, PAK1, MAPK1, CRK, BRAF, ABL2, PAK3, CRKL, CAMK2G, AREG, CBL, CAMK2D, SOS2, PAK2",0.737548910269571,0.261219441515631,FALSE
+"H1975","Input","KEGG_ETHER_LIPID_METABOLISM",-0.30959,-0.949,0.488,8863,0.696,"PLA2G2D, PAFAH1B3, PLA2G4A, PLA2G2A",0.311580177997289,0.157390760389438,FALSE
+"H1975","Input","KEGG_FATTY_ACID_METABOLISM",-0.31974,-0.948,0.459,7467,0.682,"ACADM, ALDH7A1, HADH, HADHA, ACADS, ECI1, ALDH3A2, ACAT2, ACOX3, ACSL6, CPT1A, ACOX1, ALDH2, ACADL, ADH1C",0.338187314462739,0.166215625343521,FALSE
+"H1975","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.36516,1.11,0.301,1781,0.597,"RAC2, PLA2G6, PRKCA, VAV2, VAV1, AKT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, MAPK10, PRKCD, MAPK8, MAP2K4, PIK3CA, FYN, LYN, MAPK1",0.521433504406157,0.224025668870631,FALSE
+"H1975","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.42379,1.28,0.187,2241,0.611,"RAC2, PLA2G6, PRKCA, ASAP3, LIMK1, WASF1, VAV2, VAV1, AKT1, PLPP2, MYO10, DNM2, PRKCB, PLCG2, RAF1, PIK3R2, ASAP2, PLD2, PLPP1, PRKCD, RPS6KB2, PIK3CA, PAK1, DNM1, LYN, HCK, MAPK1, DNM1L, MARCKS, ARPC4, ARPC5L, CRK, ARPC1A",0.728158393463501,0.213958789757446,FALSE
+"H1975","Input","KEGG_FOCAL_ADHESION",0.44046,1.33,0.147,1658,0.63,"FN1, COL5A1, TNC, ITGB3, RAC2, CAV2, MYLK, CAV1, PAK5, PAK6, PRKCA, COL1A2, ITGA5, THBS2, FLNA, MYL9, COL6A1, THBS1, ZYX, PARVA, VAV2, VAV1, PTEN, AKT1, COL1A1, TLN2, FLNC, ACTN3, MYL12A, PRKCB, RAF1, PIK3R2, ARHGAP5, BCAR1, MAPK10, TLN1, MAPK8, VCL, CAPN2, ACTN1, PIK3CA, ITGA3, PAK1, ILK, FYN",0.832682665251824,0.200659450546418,FALSE
+"H1975","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.35669,-1.08,0.305,7275,0.591,"ALPI, ALPP, ALPL, GGH, DHFR",0.515700160653214,0.228412519118745,FALSE
+"H1975","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.52992,1.62,0.0353,2937,1,"AKR1B1, ALDOB, ALDOC, FBP2, FBP1, PFKFB4, MTMR1, GMPPA, MTMR6, GMPPB, HK2, PFKP, SORD, HK3, PFKM, PHPT1, ALDOA",1.45222529461218,0,FALSE
+"H1975","Input","KEGG_GALACTOSE_METABOLISM",0.31091,0.942,0.467,3748,0.631,"AKR1B1, HK2, B4GALT1, PFKP, PGM2, MGAM, HK3, PFKM, GAA, GLB1, GALK1, PFKL, UGP2, GALE",0.330683119433888,0.199970640755866,FALSE
+"H1975","Input","KEGG_GAP_JUNCTION",0.35606,1.09,0.304,1189,0.587,"TUBA4A, PRKACA, PRKCA, GJA1, TUBB6, ITPR1, ADCY7, PRKCB, MAP2K2, RAF1, GNA11, GNAI2, TUBA3C",0.517126416391246,0.231361898752386,FALSE
+"H1975","Input","KEGG_GLIOMA",0.39706,1.2,0.246,1471,0.549,"TP53, PRKCA, PTEN, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, CDKN1A, PIK3CA",0.609064892896621,0.260427655549908,FALSE
+"H1975","Input","KEGG_GLUTATHIONE_METABOLISM",0.43351,1.34,0.137,1882,0.657,"ANPEP, GSTP1, GSTA5, GGT1, GSTM2, GPX4, GSS, GSTZ1, SMS, GGT7, RRM1, GPX3, G6PD",0.863279432843593,0.182434630440219,FALSE
+"H1975","Input","KEGG_GLYCEROLIPID_METABOLISM",0.34322,1.04,0.37,1674,0.59,"AKR1B1, AGPAT4, MGLL, PLPP2, DGKA, PLPP1, CEL, DGKB, GPAT3, DGKQ, GPAM",0.431798275933005,0.229147988357856,FALSE
+"H1975","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.31557,0.944,0.472,1674,0.634,"PLA2G6, AGPAT4, PLPP2, DGKA, PTDSS1, LPCAT1, MBOAT7, PLD2, PLPP1, DGKB, CHKB, GPAT3, CDS2, DGKQ, CHKA, GPAM",0.326058001365912,0.197910742118267,FALSE
+"H1975","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.57847,1.71,0.0453,1465,1,"SARDH, MAOB, SHMT1, SRR, CTH, GATM, MAOA, PSAT1",1.34390179798717,0,FALSE
+"H1975","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.32299,0.986,0.442,2937,0.595,"ALDH3B1, ALDOB, LDHA, ALDOC, GALM, PGK2, FBP2, ACSS1, FBP1, PGAM1, PGAM4, PGK1, PKM, LDHB, HK2, GPI, PFKP, PGM2, HK3, ALDH9A1, PFKM, ENO2, PKLR, ALDH1B1, ALDOA",0.354577730650908,0.22548303427145,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.42066,-1.26,0.168,8932,0.451,"CHSY3, XYLT1",0.774690718274137,0.345823458122039,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.46541,-1.45,0.0998,7497,0.368,"HS2ST1, GLCE, EXTL2, XYLT1",1.00086945871263,0.434152181326482,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.3595,-1.1,0.316,9017,0.574,"B4GAT1, B4GALT4, B3GNT2",0.500312917381596,0.241088107602027,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.23143,-0.716,0.831,7944,0.91,"HPSE, ARSB, GUSB, HEXA",0.080398976215889,0.0409586076789064,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.28895,0.858,0.627,4039,0.707,"B4GALNT1, ST3GAL2, GLB1, HEXB, SLC33A1, ST3GAL1",0.202732459169284,0.150580586203101,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3233,0.977,0.433,526,0.589,"B3GALT5",0.363512103646635,0.229884705212898,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.42236,-1.3,0.153,7885,0.45,"B4GALT3, B3GNT3, B4GAT1, ST3GAL4, B4GALT4, B3GNT2",0.815308569182401,0.346787486224656,FALSE
+"H1975","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.14942,-0.467,0.998,6278,1,"PIGU, PIGS, PIGX, PIGT, GPAA1, PIGK, PIGO",0.000869458712628891,0,FALSE
+"H1975","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.309,0.94,0.516,2512,0.627,"MTHFD1, HYI, PGP",0.287350298372789,0.202732459169284,FALSE
+"H1975","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.25085,0.761,0.759,1424,0.852,"PLA2G6, PRKACA, PRKCA, ITPR1, ADCY7, PRKCB, MAP2K2, MMP14, RAF1, GNA11, PLD2, MAPK10, PRKCD, MAPK8, CACNA1F, MAP2K4, PTK2B",0.11975822410452,0.0695604052332999,FALSE
+"H1975","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36442,1.1,0.296,1117,0.597,"PRKACA, WNT5B, FBXW11",0.528708288941061,0.224025668870631,FALSE
+"H1975","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.4457,1.35,0.127,286,0.661,"ANPEP, ITGB3, ITGA5, CD44, CSF1",0.896196279044043,0.17979854051436,FALSE
+"H1975","Input","KEGG_HISTIDINE_METABOLISM",0.38017,1.18,0.226,1308,0.564,"ALDH3B1, MAOB, HNMT, TRMT11, MAOA",0.645891560852599,0.248720896016658,FALSE
+"H1975","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.5707,-1.73,0.0292,7933,0.343,"BRCA2, POLD1, POLD3, EME1, RAD52, POLD2, MUS81, RAD54B, MRE11, BLM, RAD51",1.53461714855158,0.464705879957229,FALSE
+"H1975","Input","KEGG_HUNTINGTONS_DISEASE",-0.15189,-0.448,0.998,6482,0.998,"TBP, POLR2J, SOD1, BBC3, SIN3A, COX7B, CASP9, ATP5PB, ATP5F1C, UQCRH, VDAC1, NDUFB10, POLR2G, ATP5F1B, CREB1, SDHB, SP1, UQCRQ, HDAC2, COX7A2, ATP5PO, NDUFA4, POLR2D, COX6B1, RCOR1, SLC25A5, GRM5, COX5B, VDAC3, POLR2K, ATP5F1D, POLR2E, POLR2L, UQCRFS1, UQCRC2, POLR2C, COX5A, ATP5PF, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, PLCB2, CYC1, ATP5PD, SLC25A4, POLR2I, SOD2, UQCRB, REST, POLR2F, PLCB4, PLCB1",0.000869458712628891,0.000869458712628891,FALSE
+"H1975","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.3829,1.17,0.229,468,0.56,"MYH7, TNNC1, ITGB3, DES, ITGA5, PRKAB2, TPM4, ACE",0.640164517660112,0.2518119729938,FALSE
+"H1975","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.23182,-0.71,0.833,8770,0.903,"ITPK1, ISYNA1, INPP1, PLCB4, INPP5B, PLCB1, ITPKA",0.0793549985932124,0.0443122496864942,FALSE
+"H1975","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.39026,1.16,0.243,2488,0.567,"PYGL, PYGB, PRKACA, PRKAB2, SORBS1, PRKAR1B, AKT1, ARAF, PHKA1, PRKAG2, TRIP10, MAP2K2, FBP2, EIF4E2, RAF1, FBP1, PIK3R2, PHKB, MAPK10, RPS6KB2, MAPK8, RHEB, PIK3CA, ACACA, TSC1, TSC2, EXOC7, ACACB, MAPK1, IRS1, IKBKB, HK2, PRKAR1A, PRKACB, RAPGEF1, PRKAR2A, PDPK1, PHKG2, CRK, BRAF, PHKA2, IRS2, HK3, CRKL",0.614393726401688,0.246416941107093,FALSE
+"H1975","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.63372,-1.9,0.0177,9030,0.246,"TNFSF13B, TGFB1, IL6, CXCR4",1.75202673363819,0.609064892896621,TRUE
+"H1975","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.20607,0.634,0.932,1618,0.98,"MYC, STAT6, AKT1, OSMR, TYK2, PIK3R2, STAT5A, STAM, PIK3CA, LIFR, STAT2",0.0305840876460186,0.00877392430750515,FALSE
+"H1975","Input","KEGG_LEISHMANIA_INFECTION",-0.23201,-0.694,0.834,8989,0.912,"TLR2, TGFB1, PTGS2, FOS",0.0788339493622613,0.0400051616715838,FALSE
+"H1975","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.39867,1.22,0.221,1471,0.548,"RAC2, PRKCA, MSN, MYL9, ICAM1, VAV2, VAV1, CYBA, CLDN4, ACTN3, MYL12A, PRKCB, PLCG2, PIK3R2, ARHGAP5, GNAI2, BCAR1, CLDN16, CLDN6, VCL, ACTN1, PTK2B, PIK3CA",0.655607726314889,0.261219441515631,FALSE
+"H1975","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.40122,-1.24,0.212,7529,0.444,"ALDH7A1, HADHA, ALDH3A2, YOD1, ALDH2",0.673664139071249,0.35261702988538,FALSE
+"H1975","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.51809,-1.6,0.0729,8351,0.314,"PLA2G12A, PLA2G2D, CYP2J2, PLA2G4A, PLA2G2A",1.13727247168203,0.503070351926785,FALSE
+"H1975","Input","KEGG_LONG_TERM_DEPRESSION",0.35499,1.07,0.34,1076,0.595,"PLA2G6, PRKCA, CACNA1A, ITPR1, ARAF, GNA13, PRKCB, MAP2K2, RAF1, GNA11, GNA12, GNAI2",0.468521082957745,0.22548303427145,FALSE
+"H1975","Input","KEGG_LONG_TERM_POTENTIATION",0.42164,1.27,0.168,932,0.548,"PRKACA, PRKCA, RPS6KA6, ITPR1, RPS6KA3, RPS6KA2, ARAF, PRKCB, MAP2K2, RAF1",0.774690718274137,0.261219441515631,FALSE
+"H1975","Input","KEGG_LYSINE_DEGRADATION",-0.48523,-1.53,0.0853,7368,0.373,"SETD1A, DLST, ASH1L, ALDH7A1, HADH, HADHA, SETD1B, DOT1L, EHMT1, ALDH3A2, EHMT2, ACAT2, SETDB2, NSD3, SUV39H2, SETDB1, AADAT, NSD1, KMT5A, ALDH2, SUV39H1, NSD2, AASS, BBOX1, TMLHE",1.06905096883248,0.428291168191312,FALSE
+"H1975","Input","KEGG_LYSOSOME",0.32882,0.992,0.418,2438,0.614,"ACP5, GALC, AP3S1, CTSF, AP3D1, AP3M2, AP1M2, IGF2R, AP3B1, IDS, LIPA, AP1S2, AP3M1, CTSA, AP1M1, LGMN, AP1S3, CTSB, LAMP2, CD63, NPC2, NAGPA, CTSL, AP1S1, AP1B1, AP4E1, SMPD1, LAMP3, AP1G1, GALNS, GGA1, AP4B1",0.378823718224965,0.211831628858832,FALSE
+"H1975","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.29461,0.885,0.569,2237,0.671,"RAC2, TP53, PLA2G6, PRKACA, PRKCA, MOS, CACNA1A, FLNA, RPS6KA6, RAPGEF2, RPS6KA3, MYC, HSPB1, RPS6KA2, AKT1, RASA1, PPM1B, FLNC, RRAS2, PTPN7, PRKCB, MAP2K2, DUSP9, RAF1, MAPT, GNA12, MAPKAPK3, TAB1, MAPK10, MAPK8, CACNA1F, MAP2K4, CD14, MAP3K7, IKBKG, MAP4K3, PAK1, MAPK7, PPP3CA, PPM1A, MAPK1, MAP3K5, CHUK, IKBKB, MAP3K4, PPP3CB, TAB2, PRKACB, TGFBR1, MAPK8IP3, HSPA2, ARRB1, NFKB1, CRK, TAOK3",0.244887733604929,0.173277479831008,FALSE
+"H1975","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.72945,-2.26,0,8319,0.211,"HES1, PDX1, HNF1A, HNF4A, PAX6",Inf,0.675717544702307,TRUE
+"H1975","Input","KEGG_MELANOGENESIS",0.34859,1.07,0.335,1076,0.595,"FZD2, PRKACA, PRKCA, MITF, WNT5B, ADCY7, DVL1, PRKCB, MAP2K2, DVL2, RAF1, GNAI2",0.474955192963155,0.22548303427145,FALSE
+"H1975","Input","KEGG_MELANOMA",-0.33141,-1.01,0.374,9908,0.665,"FGF13, FGF2",0.42712839779952,0.177178354696895,FALSE
+"H1975","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.38893,1.18,0.246,895,0.564,"ALDH3B1, GSTP1, GSTA5, CYP1B1, GSTM2, CYP3A4, GSTZ1",0.609064892896621,0.248720896016658,FALSE
+"H1975","Input","KEGG_MISMATCH_REPAIR",-0.37846,-1.16,0.251,6634,0.528,"RFC2, PCNA, MSH3, RPA3, MSH6, MSH2, LIG1, RFC3, POLD1, POLD3, RFC4, POLD2, EXO1",0.600326278518962,0.277366077466188,FALSE
+"H1975","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.45627,1.38,0.111,2440,0.754,"RPS6KA6, RPS6KA3, RPS6KA2, AKT1, CAB39, EIF4E2, PIK3R2, RICTOR, STRADA, RPS6KB2, RHEB, PIK3CA, TSC1, TSC2, MAPK1, EIF4B, VEGFA, PDPK1, BRAF, ULK1",0.954677021213343,0.122628654130226,FALSE
+"H1975","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.52797,1.56,0.056,1904,1,"ICAM2, RAC2, PRKCA, ICAM1, MICA, VAV2, VAV1, ARAF, ULBP1, RAET1L, ULBP2, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, PRF1, TNFRSF10D, PTK2B, PIK3CA, PAK1, FYN, PPP3CA, MAPK1, ULBP3, PPP3CB",1.2518119729938,0,FALSE
+"H1975","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.4103,1.24,0.194,818,0.536,"F2R, F2RL1, NR3C1",0.712198270069774,0.27083521030723,FALSE
+"H1975","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.34476,1.03,0.368,2495,0.583,"TP53, RPS6KA6, RPS6KA3, RPS6KA2, RIPK2, AKT1, MAP2K2, PLCG2, RAF1, PIK3R2, YWHAH, IRAK4, MAPK10, PRKCD, IRAK1, MAPK8, PIK3CA, MAPK7, MAGED1, MAPK1, IRS1, MAP3K5, IKBKB, FOXO3, IRAK2, RAPGEF1, PDPK1, NFKB1, CRK, BRAF, IRS2, CRKL, CAMK2G",0.434152181326482,0.234331445240986,FALSE
+"H1975","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.4539,1.36,0.118,1122,0.731,"NNMT, NAMPT, ENPP1, NT5C2, NT5E",0.928117992693875,0.13608262304214,FALSE
+"H1975","Input","KEGG_NITROGEN_METABOLISM",0.34057,1.03,0.396,1268,0.583,"CA12, CA9, ASNS, CTH, CPS1",0.402304814074488,0.234331445240986,FALSE
+"H1975","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.49777,1.52,0.0696,2233,0.977,"TRIP6, RIPK2, CASP8, PYDC1, TAB1, MAPK10, MAPK8, ERBIN, TAB3, MAP3K7, IKBKG, XIAP, MAPK1, CHUK, IKBKB, TAB2, NFKB1",1.15739076038944,0.0101054362812269,FALSE
+"H1975","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.45163,-1.38,0.118,8146,0.407,"FEN1, LIG4, MRE11",0.928117992693875,0.39040559077478,FALSE
+"H1975","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.30867,0.926,0.515,949,0.638,"TP53, PRKCA, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2",0.288192770958809,0.195179321278838,FALSE
+"H1975","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.22824,0.695,0.871,1347,0.94,"DVL1, DVL2, DTX3L, JAG1",0.0599818449923368,0.0268721464003014,FALSE
+"H1975","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.37218,-1.17,0.238,7879,0.53,"LIG1, RFC3, GTF2H1, POLD1, CUL4A, POLD3, RFC4, POLE, POLD2, ERCC1, POLE2, GTF2H5, DDB2",0.623423042943488,0.275724130399211,FALSE
+"H1975","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.25682,-0.775,0.707,7008,0.853,"DPAGT1, GANAB, ALG9, MOGS, MAN1A2, B4GALT3, ALG8, MAN2A2, ALG6, MGAT5, ALG5, ALG13, ALG14, MGAT4A",0.150580586203101,0.069050968832477,FALSE
+"H1975","Input","KEGG_OLFACTORY_TRANSDUCTION",0.35894,1.1,0.309,2730,0.597,"PRKACA, PRKACB, CAMK2G, CAMK2D",0.510041520575165,0.224025668870631,FALSE
+"H1975","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44693,-1.38,0.109,9163,0.407,"DHFR, TYMS, ALDH1L1",0.962573502059376,0.39040559077478,FALSE
+"H1975","Input","KEGG_OOCYTE_MEIOSIS",0.22653,0.694,0.86,1904,0.933,"PRKACA, MOS, RPS6KA6, ITPR1, RPS6KA3, SMC1B, RPS6KA2, AR, ADCY7, YWHAH, FBXW11, PPP2R5E, PPP2R5B, SLK, PPP3CA, MAPK1, PPP2CB, PPP3CB",0.0655015487564323,0.0301183562535,FALSE
+"H1975","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.43007,-1.29,0.158,7313,0.445,"GBA, MAN2B2, MANBA, HEXA, FUCA1",0.801342913045577,0.351639989019068,FALSE
+"H1975","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.17496,-0.539,0.989,6631,1,"COX7B, ATP5ME, ATP5PB, ATP5F1C, UQCRH, ATP5MG, NDUFB10, ATP5F1B, COX11, SDHB, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, COX5B, ATP5F1D, UQCRFS1, UQCRC2, ATP12A, COX5A, ATP5PF, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, CYC1, ATP5PD, UQCRB, PPA2",0.0048037084028206,0,FALSE
+"H1975","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.2724,0.81,0.694,1894,0.78,"GALNT12, GALNT6, GALNT13, GALNT7, GALNT10, GALNT16, GALNT17",0.158640529545145,0.10790539730952,FALSE
+"H1975","Input","KEGG_P53_SIGNALING_PATHWAY",0.32705,0.999,0.406,586,0.608,"SERPINE1, TP53, STEAP3, THBS1, TP53I3, PTEN, CASP8",0.391473966422806,0.216096420727265,FALSE
+"H1975","Input","KEGG_PANCREATIC_CANCER",0.34523,1.04,0.362,2364,0.59,"RAC2, TP53, AKT1, RALB, ARAF, RAF1, PIK3R2, MAPK10, MAPK8, PIK3CA, RALA, IKBKG, MAPK1, CHUK, IKBKB, VEGFA, SMAD4, TGFBR1, CDK4, NFKB1, BRAF, RALBP1",0.441291429466834,0.229147988357856,FALSE
+"H1975","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.35781,1.12,0.282,2175,0.589,"ENPP1, PANK2, DPYD, PANK1",0.549750891680639,0.229884705212898,FALSE
+"H1975","Input","KEGG_PARKINSONS_DISEASE",-0.27786,-0.864,0.583,6631,0.799,"COX7B, CASP9, ATP5PB, ATP5F1C, UQCRH, VDAC1, NDUFB10, UBE2J1, ATP5F1B, SDHB, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, SLC25A5, COX5B, VDAC3, ATP5F1D, UQCRFS1, UQCRC2, COX5A, HTRA2, ATP5PF, COX7A2L, PARK7, UQCRC1, NDUFA5, ATP5F1E, CYC1, ATP5PD, SLC25A4, UBE2J2, UQCRB, UBE2G2, UCHL1, SNCA",0.234331445240986,0.0974532206860086,FALSE
+"H1975","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.34842,1.06,0.31,3542,0.596,"LY96, TUBA4A, PRKCA, TUBB6, TUBA3C, CD14, FYN, ARHGEF2, ARPC4, ARPC5L, CTTN, TUBB4B, ARPC1A, ARPC2, TUBA1C, TUBB3, TUBB1, CTNNB1, CDH1, ROCK2, ARPC3, ARPC1B, YWHAQ, ABL1, ARPC5, TUBA1B",0.508638306165727,0.224753740259764,FALSE
+"H1975","Input","KEGG_PATHWAYS_IN_CANCER",-0.31115,-0.938,0.467,9314,0.684,"TGFB1, AXIN2, LAMA5, IL6, SLC2A1, COL4A1, RET, WNT10A, RASSF5, TGFA, RAD51, MMP1, FZD1, SKP2, CEBPA, PML, BIRC5, FGFR2, PTGS2, FOS, LAMB4, LAMB1, MMP2, COL4A2, FGF13, FGF2",0.330683119433888,0.164943898279884,FALSE
+"H1975","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.44533,1.35,0.123,2209,0.661,"AKR1B1, XYLB, UGDH, CRYL1",0.910094888560602,0.17979854051436,FALSE
+"H1975","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.55606,1.64,0.0524,2962,1,"ALDOB, RBKS, ALDOC, FBP2, FBP1, PGLS, PRPS1, PRPS1L1, GPI, G6PD, PFKP, PGM2, PFKM, PRPS2, ALDOA, DERA",1.28066871301627,0,FALSE
+"H1975","Input","KEGG_PEROXISOME",-0.29213,-0.915,0.517,8264,0.715,"PEX11A, PRDX5, ACOX3, PHYH, SOD2, ABCD3, PEX2, ACSL6, ACOX1, PEX14, HSD17B4, SLC27A2, IDH2, NUDT19, ECH1",0.286509456906058,0.145693958198919,FALSE
+"H1975","Input","KEGG_PHENYLALANINE_METABOLISM",0.60139,1.8,0.0265,375,0.979,"ALDH3B1, MAOB, TAT, MIF",1.57675412606319,0.00921730819686218,FALSE
+"H1975","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.3277,0.98,0.446,2600,0.591,"PRKCA, ITPR1, IMPA2, PIP4K2A, PTEN, PIP4K2C, DGKA, SYNJ2, PRKCB, PLCG2, PIK3R2, PI4KA, DGKB, CDS2, PIK3CA, DGKQ, INPP4A, INPP5E, INPP5A, ITPR3, PLCD1, CDIPT, PI4KB, PIK3C3, INPPL1, INPP5K",0.350665141287858,0.228412519118745,FALSE
+"H1975","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.25598,-0.784,0.703,7977,0.853,"UROS, FECH, GUSB, MMAB, BLVRB, CP",0.153044674980176,0.069050968832477,FALSE
+"H1975","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.33577,1.01,0.384,574,0.596,"CYP27A1, ANGPTL4, PLTP, ACSL4, SORBS1, ME1, PPARG",0.415668775632469,0.224753740259764,FALSE
+"H1975","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.46509,1.41,0.0953,24,0.716,"CYP27A1",1.02090709936167,0.145086977692144,FALSE
+"H1975","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.44325,1.35,0.136,653,0.661,"CD79A, CD40, ADA, TAP1",0.866461091629782,0.17979854051436,FALSE
+"H1975","Input","KEGG_PRION_DISEASES",-0.28228,-0.862,0.617,9350,0.786,"IL6, NCAM1, C9",0.209714835966758,0.104577453960592,FALSE
+"H1975","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.29922,0.913,0.525,1471,0.648,"PRKACA, MOS, RPS6KA6, RPS6KA3, RPS6KA2, AKT1, ARAF, ADCY7, RAF1, PIK3R2, GNAI2, MAPK10, MAPK8, PIK3CA",0.279840696594043,0.188424994129407,FALSE
+"H1975","Input","KEGG_PROPANOATE_METABOLISM",-0.27114,-0.823,0.664,7467,0.811,"ACADM, ALDH6A1, ALDH7A1, HADHA, ABAT, ALDH3A2, ACAT2, HIBCH, ACSS3, ALDH2, MCEE",0.177831920631982,0.090979145788844,FALSE
+"H1975","Input","KEGG_PROSTATE_CANCER",0.30764,0.931,0.514,2391,0.636,"GSTP1, TP53, PTEN, AKT1, ARAF, AR, MAP2K2, RAF1, PIK3R2, CDKN1B, CREB5, CDKN1A, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, TCF7L1, PDPK1, NFKB1, BRAF, CCNE1",0.289036881004724,0.196542884351586,FALSE
+"H1975","Input","KEGG_PROTEASOME",0.33695,1.04,0.382,3414,0.59,"PSMB9, PSMB10, PSMF1, SEM1, PSMB8, PSME4, PSMB4, PSMD14, PSMD11, PSMD3, PSMD7, PSMD6, PSMD12, PSMD13",0.417936637088291,0.229147988357856,FALSE
+"H1975","Input","KEGG_PROTEIN_EXPORT",-0.54391,-1.67,0.0476,7537,0.33,"HSPA5, SEC61A2, SRPRA, SPCS3, SEC11A, SPCS2, SRPRB, IMMP2L, SRP14, SPCS1, SRP9",1.32239304727951,0.481486060122112,FALSE
+"H1975","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.58648,-1.8,0.0312,7805,0.307,"ATP1A4, ATP1A1, ATP1A3, PCK2, SLC4A4, ATP1B1, CA2, GLUD2",1.50584540598156,0.512861624522813,FALSE
+"H1975","Input","KEGG_PURINE_METABOLISM",0.26498,0.815,0.694,1198,0.778,"PDE5A, PDE4A, PDE4D, PAPSS2, ADSL, NME7, PFAS, ENPP1, AMPD3, ADA, ENTPD3, NT5C2, IMPDH1, AMPD1, ADCY7, ADK, NT5E, NME4, GMPR",0.158640529545145,0.109020403010311,FALSE
+"H1975","Input","KEGG_PYRIMIDINE_METABOLISM",0.21891,0.654,0.91,1128,0.968,"UPP1, CDA, NME7, ENTPD3, NT5C2, TYMP, NT5E, NME4",0.0409586076789064,0.0141246426916063,FALSE
+"H1975","Input","KEGG_PYRUVATE_METABOLISM",0.29567,0.889,0.588,1756,0.671,"AKR1B1, ME1, LDHA, HAGHL, ACSS1, ACACA, PKM, LDHB, ACACB",0.230622673923862,0.173277479831008,FALSE
+"H1975","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.36929,1.13,0.272,1675,0.602,"FN1, ITGB3, RAC2, MYLK, PAK5, PAK6, ITGA5, MOS, MSN, MYL9, DIAPH2, MYH9, LIMK1, F2R, WASF1, VAV2, PIP4K2A, VAV1, ARAF, ENAH, PIP4K2C, ACTN3, GNA13, RRAS2, MYL12A, MYH10, MAP2K2, RAF1, PIK3R2, GNA12, SSH3, BCAR1, VCL, ACTN1, CD14, PIK3CA, ITGA3, PAK1, ARHGEF4, SSH2",0.565431095965801,0.220403508742175,FALSE
+"H1975","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.38118,-1.15,0.252,9894,0.509,"PRKAA2",0.598599459218456,0.293282217663241,FALSE
+"H1975","Input","KEGG_RENAL_CELL_CARCINOMA",0.33092,1.01,0.402,3029,0.596,"PAK5, PAK6, AKT1, ARAF, ETS1, MAP2K2, RAF1, PIK3R2, FLCN, PIK3CA, PAK1, MAPK1, VEGFA, RAPGEF1, CRK, BRAF, PAK3, CRKL, TGFB2, SOS2, PAK2, VHL, EGLN1",0.39577394691553,0.224753740259764,FALSE
+"H1975","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.67973,2.05,0.00921,518,0.4,"ANPEP, CPA3, ACE, THOP1",2.03574036980315,0.397940008672038,FALSE
+"H1975","Input","KEGG_RETINOL_METABOLISM",-0.65655,-1.98,0.0198,8808,0.436,"DHRS3, RDH10, DGAT1, ADH1C, DHRS9, ALDH1A1",1.70333480973847,0.360513510731414,FALSE
+"H1975","Input","KEGG_RIBOFLAVIN_METABOLISM",0.69332,2.12,0.00367,1404,0.533,"ACP5, ENPP1, MTMR1, MTMR6",2.43533393574791,0.273272790973428,FALSE
+"H1975","Input","KEGG_RIBOSOME",0.42905,1.27,0.171,4061,0.548,"RPS25, RPL37, RPL22L1, RPL29, RPS10, FAU, RPS7, RPS15, RPL27, RPS16, RPS26, RPS15A, RPL4, RPL37A, RPL21, RPS24, RPS8, RPL24, RSL24D1, RPL28, RPS9, RPL35A, RPS13, RPL14, UBA52, RPL35, RPL30, RPS21, RPL10, RPL36, RPS11, RPS5, RPS19, RPL8, RPL9, RPL3, RPL32, RPS3A, RPS3, RPL18A, RPL6, RPS18, RPL31, RPL26, RPS2, RPS20, RPS4X, RPL13A, RPL12, RPL5, RPL22, RPS23, RPL34, RPS28, RPL18, RPL15, RPLP0, RPL17, RPL11, RPL36A, RPL36AL, RPL23A, RPS27L, RPL7A, RPL7, RPL10A",0.767003889607846,0.261219441515631,FALSE
+"H1975","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.48878,1.49,0.082,3047,0.813,"TBKBP1, CASP8, DHX58, TRADD, DDX58, IFIH1, MAPK10, ISG15, MAPK8, TRIM25, IRF7, MAVS, MAP3K7, IKBKG, OTUD5, ATG12, CHUK, IKBKB, FADD, NFKB1, RIPK1, TRAF3, MAPK14, CASP10, MAPK9, ATG5",1.08618614761628,0.0899094544059319,FALSE
+"H1975","Input","KEGG_RNA_DEGRADATION",0.1707,0.514,0.997,7870,1,"EDC3, TTC37, PATL1, SKIV2L, PAPOLA, EDC4, CNOT4, XRN1, ZCCHC7, C1D, ENO2, DCP1A, MPHOSPH6, CNOT1, DCP1B, CNOT7, DDX6, ENO1, CNOT9, CNOT3, PARN, CNOT10, EXOSC7, EXOSC10, CNOT2, XRN2, MTREX, LSM1, DIS3, CNOT6L, HSPD1, HSPA9, LSM7, EXOSC3, CNOT6, WDR61, EXOSC2, CNOT8, EXOSC4, TENT4A, PAPOLG, LSM2, LSM6, LSM4, EXOSC1, EXOSC9, EXOSC5, EXOSC6, DCPS, ENO3, EXOSC8, LSM8, DCP2, LSM3",0.00130484168834428,0,FALSE
+"H1975","Input","KEGG_RNA_POLYMERASE",-0.51817,-1.6,0.0615,5450,0.314,"POLR1A, POLR2H, POLR3G, POLR3H, POLR3C, POLR3GL, POLR2B, POLR1B, POLR3K, POLR2J, POLR3F, POLR2G, POLR2D, POLR1C, POLR1D, POLR2K, POLR2E, POLR2L, POLR2C, POLR1E, POLR2I, POLR2F",1.21112488422458,0.503070351926785,FALSE
+"H1975","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.50335,1.5,0.0826,1497,0.943,"GGT1, PAPSS2, CTH, TRMT11, SCLY, GGT7",1.08301995267962,0.0254883072626717,FALSE
+"H1975","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.35355,-1.07,0.323,8221,0.591,"PIK3R1, COL4A6, RB1, CKS1B, TRAF4, PIAS1, ITGA6, RXRB, E2F3, BCL2L1, LAMA5, COL4A1, SKP2, PTGS2, FHIT, LAMB4, LAMB1, COL4A2",0.490797477668897,0.228412519118745,FALSE
+"H1975","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.30308,0.908,0.553,2934,0.65,"STX2, STX8, STX10, YKT6, VTI1B, SNAP29, STX3, BET1, VTI1A, STX4, VAMP7, STX12, USE1",0.257274868695302,0.187086643357144,FALSE
+"H1975","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.28537,-0.861,0.575,9899,0.771,"SMPD3",0.24033215531037,0.112945621949043,FALSE
+"H1975","Input","KEGG_SPLICEOSOME",-0.48324,-1.5,0.0773,5796,0.381,"SRSF6, CDC5L, SNRPD3, PPIL1, SRSF5, BUD31, SNRPE, PCBP1, SF3B1, PRPF8, EIF4A3, RBMX, DDX46, U2SURP, CRNKL1, LSM7, EFTUD2, HNRNPK, DDX5, RBM17, SRSF10, PRPF6, SRSF8, XAB2, SNRPB, CDC40, SF3A2, SNRNP200, HSPA8, SF3A1, SRSF2, LSM2, U2AF1, LSM6, DHX8, SNRNP70, SART1, LSM4, DDX42, TCERG1, DDX39B, SRSF7, TXNL4A, ACIN1, SRSF1, AQR, ALYREF, PQBP1, ISY1, DHX15, TRA2B, CCDC12, USP39, PRPF19, U2AF2, SF3B3, SF3B5, PRPF40B, SNRPG, SF3B4, WBP11, SF3B2, LSM8, MAGOHB, LSM3, PPIH, ZMAT2, PHF5A, SF3A3, BCAS2, HNRNPA1, SNRNP40, PRPF18, PRPF38A, THOC3, RBM8A, PPIE, SNU13, CWC15, HNRNPC, SNRPC, SNRNP27, SYF2, DDX23, HSPA1L, PUF60, SLU7, SNRPF, TRA2A, SRSF3, HNRNPA3, SRSF4, PRPF38B, SRSF9",1.11182050608168,0.419075024324381,FALSE
+"H1975","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.50195,1.53,0.0718,2472,1,"PGM2L1, PYGL, PYGB, ENPP1, GBE1, UGDH, HK2, GPI, PGM2, MGAM, HK3",1.1438755557577,0,FALSE
+"H1975","Input","KEGG_STEROID_BIOSYNTHESIS",-0.55301,-1.67,0.0438,8363,0.33,"SQLE, SOAT2, CYP27B1, DHCR24, MSMO1, FDFT1, HSD17B7, DHCR7, CYP51A1, TM7SF2",1.3585258894959,0.481486060122112,FALSE
+"H1975","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44592,-1.36,0.117,9071,0.411,"HSD17B7, AKR1D1, AKR1C3, AKR1C1, HSD11B2, HSD17B2",0.931814138253838,0.386158178123931,FALSE
+"H1975","Input","KEGG_SULFUR_METABOLISM",-0.47961,-1.47,0.0964,9330,0.367,"SUOX, SULT1A1",1.01592296609717,0.435333935747911,FALSE
+"H1975","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.4798,1.44,0.104,1782,0.829,"C4A, CD40, ACTN3, C3, ACTN1, C1R, TRIM21",0.98296666070122,0.0814454694497265,FALSE
+"H1975","Input","KEGG_TASTE_TRANSDUCTION",0.42289,1.27,0.176,209,0.548,"PRKACA, CACNA1A",0.75448733218585,0.261219441515631,FALSE
+"H1975","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.54759,-1.66,0.0522,7326,0.307,"PDSS1, MVK, HMGCS1, ACAT2, IDI1, DHDDS, HMGCR",1.28232949699774,0.512861624522813,FALSE
+"H1975","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.30038,0.903,0.547,2687,0.652,"THBS2, MYC, AMH, THBS1, SMURF1, RPS6KB2, RBL2, ZFYVE16, E2F4, MAPK1, PPP2CB, SMAD4, TGFBR1, ACVR1, E2F5, SMAD1, SMURF2, TGFB2",0.262012673666569,0.18575240426808,FALSE
+"H1975","Input","KEGG_THYROID_CANCER",0.42462,1.27,0.191,3100,0.548,"TP53, MYC, PPARG, MAP2K2, NCOA4, MAPK1, TCF7L1, BRAF, RXRG, PAX8, TPM3, CCND1, CTNNB1, CDH1, TFG",0.718966632752272,0.261219441515631,FALSE
+"H1975","Input","KEGG_TIGHT_JUNCTION",0.32384,0.984,0.445,1251,0.591,"MYH7, PRKCA, MYH11, MYL9, MYH9, PTEN, AKT1, PRKCH, LLGL1, CLDN4, ACTN3, RRAS2, MYL12A, MYH10, EPB41L2, PRKCB, GNAI2, CASK, PRKCD, CLDN16, CLDN6, EPB41L1, TJP2",0.351639989019068,0.228412519118745,FALSE
+"H1975","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.3736,1.12,0.285,2278,0.589,"LY96, IRF5, CD40, AKT1, CASP8, MAP2K2, PIK3R2, IRAK4, TAB1, MAPK10, IRAK1, MYD88, MAPK8, IRF7, MAP2K4, CD14, PIK3CA, MAP3K7, IKBKG, TOLLIP, MAPK1, CHUK, IKBKB, TAB2, FADD, NFKB1, LBP",0.54515513999149,0.229884705212898,FALSE
+"H1975","Input","KEGG_TRYPTOPHAN_METABOLISM",0.40515,1.24,0.205,1308,0.536,"MAOB, CYP1B1, KYNU, GCDH, EHHADH, MAOA",0.688246138944246,0.27083521030723,FALSE
+"H1975","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.45913,1.37,0.121,2992,0.741,"CACNA1A, PIK3R2, MAPK10, PRKCD, MAPK8, PIK3CA, PKM, MAPK1, IRS1, IKBKB, HK2, IRS2, HK3, ABCC8, PKLR, MTOR, INSR, MAPK9",0.91721462968355,0.130181792020672,FALSE
+"H1975","Input","KEGG_TYROSINE_METABOLISM",0.45094,1.33,0.166,1308,0.63,"ALDH3B1, MAOB, TAT, MIF, GSTZ1, TRMT11, MAOA",0.779891911959945,0.200659450546418,FALSE
+"H1975","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35193,1.05,0.364,3051,0.606,"PAK5, PAK6, CARD11, VAV2, VAV1, AKT1, MALT1, MAP2K2, RAF1, PIK3R2, PIK3CA, MAP3K7, IKBKG, PAK1, FYN, PPP3CA, MAPK1, CHUK, IKBKB, PPP3CB, CDK4, PDPK1, NFKB1, PAK3, NFATC3, CBL, SOS2, PAK2, MAPK14, BCL10, MAPK9, NFAT5",0.438898616350944,0.217527375833714,FALSE
+"H1975","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.21391,0.655,0.912,1755,0.976,"UBA7, ITCH, UBE2O, CUL4B, UBE3C, HUWE1, UBA6, CUL7, KEAP1, MGRN1, SMURF1, FBXW11, HERC1, UBE2M, HERC4, WWP2, STUB1, UBA1, ERCC8, BIRC6, FBXW8, XIAP",0.0400051616715838,0.0105501823333082,FALSE
+"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.25119,-0.765,0.749,8873,0.84,"BCAT1",0.125518182300534,0.0757207139381184,FALSE
+"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.42544,-1.28,0.184,7467,0.441,"ACADM, ALDH6A1, ALDH7A1, HADH, HADHA, ACADS, OXCT1, ABAT, ALDH3A2, HMGCS1, ACAT2, HIBCH, BCAT1, ALDH2, DBT, AUH, MCEE",0.735182176990464,0.355561410532161,FALSE
+"H1975","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.43447,1.31,0.15,1381,0.651,"CALD1, MYLK, PLA2G6, PRKACA, PRKCA, MYH11, MYL9, ITPR1, PRKCH, ARAF, ADCY7, GNA13, MYL6, PRKCB, MAP2K2, RAF1, GNA11, GNA12, PRKCD, MYL6B, CACNA1F",0.823908740944319,0.186419011431808,FALSE
+"H1975","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.41656,1.26,0.196,2604,0.552,"PRKACA, DYNC1I2, DYNC1H1, DYNC1LI2, DCTN1, DYNC1LI1, DYNC2LI1, CREB5, DCTN2, RAB5B, DCTN4, DCTN5, DYNC2H1, PRKACB, GNAS, STX4, RAB5A",0.707743928643524,0.258060922270801,FALSE
+"H1975","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.43332,1.3,0.174,1074,0.609,"NOS3, RAC2, PLA2G6, PRKCA, HSPB1, AKT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, MAPKAPK3",0.7594507517174,0.215382707367125,FALSE
+"H1975","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.34744,1.03,0.358,2785,0.583,"PRKACA, PRKCA, KDELR1, PRKCB, PLCG2, TJP2, PRKACB, ATP6V1C1, ATP6V1G1, GNAS, ATP6V1D, ATP6V1E1, ATP6V1B2, TCIRG1",0.446116973356126,0.234331445240986,FALSE
+"H1975","Input","KEGG_VIRAL_MYOCARDITIS",0.47521,1.43,0.101,825,0.752,"MYH7, RAC2, CAV1, MYH11, MYH9, ICAM1, CD40, CASP8, MYH10",0.995678626217357,0.123782159408358,FALSE
+"H1975","Input","KEGG_WNT_SIGNALING_PATHWAY",0.32988,0.989,0.435,2201,0.612,"RAC2, FZD2, TP53, PRKACA, PRKCA, PRICKLE1, MYC, WNT5B, DVL1, PRKCB, DVL2, FBXW11, MAPK10, PPP2R5E, MAPK8, DAAM1, MAP3K7, PPP2R5B, PPP3CA, PPP2CB, PPP3CB, APC, SMAD4, PRKACB, TCF7L1, PPP2R5C",0.361510743045363,0.213248577854439,FALSE
+"H2009","Input","KEGG_ABC_TRANSPORTERS",0.32322,1.09,0.298,1760,0.498,"ABCG2, ABCD1, ABCC1, ABCA1, ABCC3",0.525783735923745,0.302770657240282,FALSE
+"H2009","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.46475,-1.51,0.0914,7134,0.344,"RPS6KB1, MTOR, PIK3CB, MAP2K2, IKBKG, STAT5A, NFKB1, SOS1, RPS6KB2, PIK3R2, MAPK1, ARAF, RELA, AKT1, BRAF, MAPK3, PIK3CA, PIK3R1, AKT2, CEBPA, IKBKB, EIF4EBP1, RAF1, CCND1",1.03905380426617,0.46344155742847,FALSE
+"H2009","Input","KEGG_ADHERENS_JUNCTION",0.26174,0.875,0.581,1714,0.657,"RAC2, CTNNB1, CDH1, CTNND1, CTNNA1, CTNNA2, LMO7, NECTIN4, TJP1, NECTIN1, ACTN4, BAIAP2, MET, AFDN, SSX2IP, ERBB2, IGF1R, SORBS1, PTPRJ, YES1, NECTIN2",0.235823867609669,0.182434630440219,FALSE
+"H2009","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.49211,-1.57,0.0657,6982,0.332,"ACSL5, MAPK10, ACACB, MTOR, NFKBIB, IKBKG, PRKCQ, NFKB1, STK11, PRKAG2, TRAF2, PRKAB2, CPT1A, PCK2, MAPK8, PRKAB1, NFKBIE, RELA, AKT1, CAMKK2, PTPN11, PRKAA1, AKT2, PRKAG1, IKBKB",1.18243463044022,0.478861916295964,FALSE
+"H2009","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.41557,-1.3,0.157,8405,0.373,"CAD, ADSL, ASL, NIT2, ASNS, CPS1, ASS1",0.804100347590766,0.428291168191312,FALSE
+"H2009","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.24436,-0.773,0.719,6160,0.84,"IRS2, INSR, PRKCA, HSD11B2, PRKCB, PIK3CB, PIK3R2, MAPK1, NEDD4L, MAPK3, PIK3CA, PIK3R1",0.143271109617117,0.0757207139381184,FALSE
+"H2009","Input","KEGG_ALZHEIMERS_DISEASE",-0.1856,-0.612,0.958,6977,0.971,"CDK5, ATP5PB, CAPN2, NDUFAB1, CASP9, COX6C, CASP8, CASP3, MAPK1, BACE2, ATP2A3, APAF1, IDE, FADD, GAPDH, APBB1, MAPK3, MME, CAPN1, GSK3B, PLCB4, CASP7, PLCB2",0.0186344909214556,0.0127807700919951,FALSE
+"H2009","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.23689,-0.765,0.739,5956,0.837,"NARS2, FARS2, SARS2, EARS2, WARS2, MTFMT, FARSB, VARS2, FARSA, SEPSECS",0.131355561605174,0.07727454200674,FALSE
+"H2009","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.6384,-2.05,0.00699,6681,0.374,"NANS, GFPT2, GMPPA, UGP2, GCK, CYB5R1, GNE, HK3, NAGK, GALE, PGM2, GALK1, PGM1, GFPT1, GALK2, PMM2, GMDS, MPI, PGM3, PMM1, GNPDA2, GMPPB, GALT, UAP1, FPGT, GNPNAT1, GNPDA1, GPI, AMDHD2",2.15552282425432,0.42712839779952,FALSE
+"H2009","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.25587,-0.821,0.66,7014,0.779,"CCS, CASP9, MAPK14, MAPK12, CASP1, CASP3, NEFM, PRPH, PRPH2, APAF1, BAX, SOD1, MAP2K3",0.180456064458131,0.108462542327436,FALSE
+"H2009","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.2992,0.992,0.408,2758,0.534,"CTSS, CTSL, CD74, RFXAP, RFXANK, CTSB, CALR, HSPA5, CREB1, RFX5, TAPBP, PSME3, NFYB, HSPA1L, IFI30, PDIA3",0.38933983691012,0.272458742971444,FALSE
+"H2009","Input","KEGG_APOPTOSIS",-0.33497,-1.07,0.311,7026,0.482,"CAPN2, IRAK4, PIK3CB, CASP9, CASP6, IKBKG, NFKB1, BIRC2, CASP8, CASP3, TRAF2, PIK3R2, APAF1, IL1A, MYD88, RIPK1, BAX, RELA, AKT1, FADD, DFFB, PIK3CA, CAPN1, PIK3R1, AKT2, CASP7, IKBKB",0.507239610973163,0.31695296176115,FALSE
+"H2009","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.31385,1.02,0.388,356,0.541,"GPX1, PLA2G12A, GGT5",0.411168274405793,0.266802734893431,FALSE
+"H2009","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.25409,0.847,0.572,575,0.684,"GLUD2, GATM, ARG1, ALDH1B1, OAT, MAOA, PYCR1",0.242603971206976,0.164943898279884,FALSE
+"H2009","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.7275,2.34,0,765,0.226,"ITGB6, ITGB4, ITGA2B, DSC2, GJA1, ITGA6, DSG2, PKP2, ITGA3, CTNNB1, LMNA, ITGA4, ITGB8, CTNNA1, CTNNA2, ITGA5, ITGA2, ITGAV, ACTN4",Inf,0.645891560852599,TRUE
+"H2009","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56676,1.82,0.0312,2597,0.186,"ALDH1B1, ALDH2, UGDH, ALDH7A1, ALDH3A2",1.50584540598156,0.730487055782084,TRUE
+"H2009","Input","KEGG_AXON_GUIDANCE",0.23453,0.798,0.705,1058,0.747,"RAC2, SEMA4B, EFNB2, EPHA1, SEMA4D, EPHA2, HRAS, ROBO1, EPHB2, KRAS, NRAS, MET, PLXNB2, SEMA7A",0.151810883008601,0.126679398184601,FALSE
+"H2009","Input","KEGG_BASAL_CELL_CARCINOMA",0.32696,1.08,0.312,2067,0.502,"TP53, CTNNB1, FZD6, DVL1, WNT5B, FZD7, APC",0.505845405981557,0.299296282854981,FALSE
+"H2009","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.15908,0.526,0.99,6214,1,"TAF12, GTF2H1, TAF4, TAF11, TAF5, GTF2I, GTF2B, GTF2H2, TAF5L, TAF6, TAF9, TAF10, GTF2F2, TAF1, GTF2H3, TAF2, GTF2E2, GTF2H4, GTF2F1, TAF7, TAF6L, GTF2E1, GTF2A2, TAF9B, TBP, GTF2A1",0.00436480540245009,0,FALSE
+"H2009","Input","KEGG_BASE_EXCISION_REPAIR",-0.25731,-0.826,0.645,5421,0.779,"POLE4, UNG, PARP1, POLE2, POLL, MUTYH, POLE, FEN1, PARP4, MPG, NTHL1, NEIL2, SMUG1, HMGB1, APEX1",0.190440285364732,0.108462542327436,FALSE
+"H2009","Input","KEGG_BETA_ALANINE_METABOLISM",0.40571,1.32,0.143,2236,0.351,"ACADM, ALDH1B1, ECHS1, HADHA, ALDH2, SMS, ALDH7A1",0.844663962534938,0.454692883534176,FALSE
+"H2009","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.46174,1.51,0.0791,1789,0.261,"FADS2, ACAA1, ACOX1, PECR, HADHA, ELOVL6, ELOVL5, FADS1",1.10182351650232,0.583359492661719,FALSE
+"H2009","Input","KEGG_BLADDER_CANCER",0.33547,1.11,0.29,1410,0.492,"TP53, MMP1, CDH1, VEGFA, CDKN2A, HRAS, KRAS, NRAS, CXCL8, ERBB2, VEGFC, MYC",0.537602002101044,0.30803489723264,FALSE
+"H2009","Input","KEGG_BUTANOATE_METABOLISM",0.44758,1.5,0.0806,2315,0.237,"ALDH1B1, OXCT1, ACAT1, ECHS1, HADH, HADHA, PDHA1, PDHB, ALDH2, ALDH7A1, HMGCL",1.09366495819491,0.625251653989896,FALSE
+"H2009","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.34974,-1.1,0.303,6569,0.466,"BTK, BCL10, VAV3, PPP3CC, PTPN6, PIK3AP1, MAP2K1, PRKCB, PIK3CB, NFKBIB, PLCG2, MAP2K2, IKBKG, NFKB1, SOS1, NFATC2, PIK3R2, MAPK1, VAV2, NFKBIE, RELA, AKT1, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, MALT1, IKBKB, RAF1",0.518557371497695,0.33161408331,FALSE
+"H2009","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.19421,-0.621,0.932,7972,0.972,"PHKG2, ATP2A3, PHKB, SLC8A1, PDGFRA, PDGFRB, PPID, P2RX4, PLCG1, PLCB4, PLCB2",0.0305840876460186,0.0123337350737254,FALSE
+"H2009","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.34627,1.12,0.287,1871,0.502,"TNNC1, ATP1A2, SLC9A6, ATP1B1, SLC9A1, UQCRH, CACNA2D1, UQCRB, UQCRFS1",0.542118103266008,0.299296282854981,FALSE
+"H2009","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.57772,1.93,0.0205,843,0.235,"CDH15, CDH3, CNTN1, ITGB2, CD274, CLDN7, ITGA6, F11R, SDC4, ALCAM, CDH1, ITGA4, ITGB8, NLGN2, CD276, ITGAV, CD58, CD99, NECTIN1, ICAM2, PVR, ICAM1",1.68824613894425,0.628932137728264,TRUE
+"H2009","Input","KEGG_CELL_CYCLE",-0.22933,-0.745,0.788,7610,0.847,"CCND3, TFDP2, CDK1, ABL1, YWHAQ, YWHAG, BUB1B, CDKN1A, SMAD2, TGFB3, ORC6, CDK6, GSK3B, PTTG1, CDKN1B, CDKN2C, CCND1, RB1",0.103473782510445,0.0721165896692931,FALSE
+"H2009","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.4488,-1.47,0.0777,7050,0.362,"PRKCB, ROCK1, PXN, PIK3CB, NFKBIB, PTK2B, IKBKG, CRKL, NFKB1, SOS1, GNAI1, PTK2, PIK3R2, MAPK1, VAV2, GSK3A, CRK, ROCK2, FOXO3, PRKCZ, ADCY5, RELA, PREX1, AKT1, BRAF, GRK2, MAPK3, ADCY6, PIK3CA, CCL13, CCL20, GSK3B, PIK3R1, AKT2, PLCB4, STAT2, IKBKB, ELMO1, CSK, PLCB2, RAF1, CXCR4, WAS",1.10957898119909,0.441291429466834,FALSE
+"H2009","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.44086,-1.41,0.124,7329,0.344,"MAP2K2, IKBKG, CRKL, STAT5A, NFKB1, SOS1, ABL1, PIK3R2, MAPK1, CRK, ARAF, CDKN1A, RELA, CBL, AKT1, BRAF, TGFB3, MAPK3, PTPN11, PIK3CA, CDK6, PIK3R1, AKT2, CBLB, IKBKB, CDKN1B, GAB2, RAF1, CCND1, RB1",0.906578314837765,0.46344155742847,FALSE
+"H2009","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.65024,2.12,0.00676,1274,0.156,"BHLHE41, BHLHE40, CLOCK",2.17005330405836,0.806875401645538,TRUE
+"H2009","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.30027,0.988,0.404,3184,0.53,"SDHA, SDHB, IDH3A, PDHA1, PDHB, SUCLG2, SUCLG1, DLST, MDH2, ACO2, IDH3G, FH, PC, DLD, IDH3B, SDHD",0.393618634889395,0.275724130399211,FALSE
+"H2009","Input","KEGG_COLORECTAL_CANCER",-0.29448,-0.934,0.514,6980,0.623,"MAP2K1, APPL1, MAPK10, PIK3CB, CASP9, CASP3, PIK3R2, MAPK1, MAPK8, ARAF, SMAD2, BAX, AKT1, BRAF, TGFB3, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, RAF1, CCND1",0.289036881004724,0.20551195334083,FALSE
+"H2009","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.56122,1.84,0.0353,587,0.193,"PLAT, F3, SERPINA1, PLAU, THBD, MBL2, CFI, PLAUR, TFPI, CD55, PROS1",1.45222529461218,0.714442690992226,TRUE
+"H2009","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.42514,-1.34,0.159,6006,0.359,"AHCYL1, AHCYL2, LDHB, TAT, MPST, MAT2A, CTH, ADI1, MTR, MAT1A, ENOPH1, SDS, LDHA, AHCY, CDO1, CBS, SRM",0.798602875679548,0.444905551421681,FALSE
+"H2009","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.28406,0.951,0.487,2322,0.55,"LIFR, OSMR, TNFRSF1A, VEGFA, TNFSF9, IL13RA1, EPO, IL1R1, LTBR, MET, IL1RAP, TGFB2, CXCL8, VEGFC, TNFRSF10B, PDGFC, TNFRSF12A, TNFRSF10A, ACVR1, TNFSF13B, IL10RB, IL25, CD40",0.312471038785366,0.259637310505756,FALSE
+"H2009","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.38272,-1.24,0.209,7218,0.416,"NFKBIB, IKBKG, NFKB1, CASP1, IRF3, IL18, DDX58, RIPK1, TBK1, RELA, PYCARD, IKBKB",0.679853713888946,0.380906669373257,FALSE
+"H2009","Input","KEGG_DILATED_CARDIOMYOPATHY",0.53846,1.77,0.037,1330,0.188,"ITGB6, TNNC1, ITGB4, ITGA2B, ITGA6, ITGA3, LMNA, ITGA4, ITGB8, ITGA5, ITGA2, ITGAV, TTN, SGCB, TGFB2, CACNA2D1, DAG1",1.431798275933,0.72584215073632,TRUE
+"H2009","Input","KEGG_DNA_REPLICATION",0.30351,0.995,0.406,3899,0.539,"POLA2, MCM3, POLD4, RFC4, SSBP1, RFC1, RFC2, RNASEH2A, RPA3, MCM4, RFC3, RFC5, MCM7, POLD3, MCM2, POLE3, POLA1, PRIM2, RPA2, PCNA, MCM6, POLD2, MCM5, RPA1, LIG1",0.391473966422806,0.268411234813261,FALSE
+"H2009","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.3217,1.06,0.327,866,0.511,"NOTCH3, ETV6, KRAS",0.485452247339714,0.291579099865287,FALSE
+"H2009","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.43435,-1.41,0.119,8535,0.344,"ALDH3A1, GSTZ1, GSTO1, GSTP1, GSTM3, ADH5",0.924453038607469,0.46344155742847,FALSE
+"H2009","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42153,-1.38,0.139,6255,0.333,"GUSB, UCK2, UCK1, TK1, TK2, IMPDH1, GMPS, UPP1, NAT1, DPYD, XDH, HPRT1, IMPDH2, UMPS, TPMT, ITPA",0.856985199745905,0.47755576649368,FALSE
+"H2009","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.64879,2.15,0.00926,772,0.181,"ITGB6, LAMC2, COL6A1, TNC, ITGB4, ITGA2B, LAMB3, ITGA6, ITGA3, SDC4, ITGA4, ITGB8, LAMA3, LAMA4, ITGA5, ITGA2, LAMB1, ITGAV, COL6A6, CD47",2.03338901331807,0.742321425130815,TRUE
+"H2009","Input","KEGG_ENDOCYTOSIS",-0.37891,-1.21,0.23,6772,0.416,"EHD4, SMAP2, VPS37C, SH3GLB2, PARD6G, CLTC, SH3GLB1, PARD6B, CHMP6, F2R, VPS36, RABEP1, ASAP1, DNM3, VPS4A, EHD2, MVB12A, PDCD6IP, ASAP2, VTA1, DNM2, SH3GL1, USP8, CHMP4A, CHMP4B, VPS28, LDLRAP1, PRKCZ, NEDD4L, VPS37A, VPS4B, ACAP2, PDGFRA, TSG101, NEDD4, CBL, SNF8, PRKCI, ARFGAP2, EHD1, SMAP1, GRK2, FGFR2, CHMP5, IQSEC1, EHD3, TRAF6, CHMP2A, VPS25, ARAP2, CBLB, ARAP1, ACAP3, CXCR4, ARFGAP1, ARFGAP3",0.638272163982407,0.380906669373257,FALSE
+"H2009","Input","KEGG_ENDOMETRIAL_CANCER",-0.30712,-0.998,0.418,7206,0.572,"PIK3CB, CASP9, MAP2K2, SOS1, PTEN, PIK3R2, MAPK1, FOXO3, ARAF, AKT1, BRAF, ILK, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, RAF1, CCND1",0.378823718224965,0.242603971206976,FALSE
+"H2009","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.35331,-1.13,0.262,7031,0.459,"MAPK10, ATP6V1E1, ATP6V1G1, PLCG2, IKBKG, NFKB1, MAPK14, MAPK12, CASP3, ATP6V1H, MAPK8, MAP2K4, ATP6V1B2, ATP6V1B1, ATP6V1A, ATP6V1C1, RELA, PTPN11, JAM3, PLCG1, IKBKB, CSK",0.581698708680255,0.338187314462739,FALSE
+"H2009","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.41731,-1.33,0.128,6980,0.363,"MAP2K1, PAK3, MAPK10, PRKCB, RPS6KB1, MTOR, CAMK2B, PIK3CB, PAK2, PLCG2, MAP2K2, NCK1, CRKL, STAT5A, SOS1, RPS6KB2, MAP2K7, PTK2, ABL1, PIK3R2, MAPK1, MAPK8, MAP2K4, CRK, ARAF, CDKN1A, CBL, AKT1, BRAF, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, PLCG1, CBLB, CDKN1B, EIF4EBP1, RAF1",0.892790030352132,0.440093374963888,FALSE
+"H2009","Input","KEGG_ETHER_LIPID_METABOLISM",0.58448,1.89,0.0208,795,0.202,"LPCAT1, PLPP2, PLA2G12A, CHPT1, PLPP3, LPCAT2, AGPS",1.68193666503724,0.694648630553376,TRUE
+"H2009","Input","KEGG_FATTY_ACID_METABOLISM",0.49933,1.62,0.0523,1776,0.226,"ACADM, ALDH1B1, ACAA1, ACOX1, ACADVL, CPT2, ACAT1, ECHS1, HADHB, HADH, HADHA, ACSL4, ACADSB, ECI2, ACSL3, ALDH2",1.28149831113273,0.645891560852599,FALSE
+"H2009","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34406,-1.13,0.29,6980,0.459,"MAP2K1, MAPK10, PRKCB, PIK3CB, PLCG2, MAP2K2, MAPK14, MAPK12, SOS1, MAP2K7, PIK3R2, MAPK1, VAV2, MAPK8, MAP2K4, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, MAP2K3, GAB2, RAF1",0.537602002101044,0.338187314462739,FALSE
+"H2009","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.33471,-1.1,0.306,6267,0.466,"ARPC2, PRKCA, PAK1, ARPC4, DNM1L, PIP4K2B, ARPC1A, VAV3, CFL1, WASL, MAP2K1, PRKCB, RPS6KB1, PIK3CB, PLCG2, AMPH, CRKL, ASAP1, LIMK2, DNM3, RPS6KB2, ASAP2, DNM2, PIK3R2, MAPK1, VAV2, CRK, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, GAB2, RAF1, WAS",0.51427857351842,0.33161408331,FALSE
+"H2009","Input","KEGG_FOCAL_ADHESION",0.33848,1.1,0.318,765,0.495,"ITGB6, LAMC2, RAC2, COL6A1, TNC, ITGB4, ITGA2B, LAMB3, ITGA6, ITGA3, CAV2, CTNNB1, VEGFA, ITGA4, ITGB8, LAMA3, LAMA4, PIK3R3, ITGA5, FLNB, ITGA2, HRAS, LAMB1, ITGAV, COL6A6, JUN, ACTN4",0.497572880015567,0.305394801066431,FALSE
+"H2009","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.54975,-1.76,0.0243,5955,0.376,"QDPR, PTS, SPR, DHFR",1.61439372640169,0.424812155072339,FALSE
+"H2009","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.52604,-1.73,0.032,7189,0.349,"HK3, TPI1, ALDOA, SORD, KHK, PMM2, GMDS, MPI, PMM1, PHPT1, PFKFB3, GMPPB, PFKP, MTMR2, MTMR6, FPGT, PFKM, PFKL",1.49485002168009,0.45717457304082,FALSE
+"H2009","Input","KEGG_GALACTOSE_METABOLISM",-0.48625,-1.6,0.0545,6911,0.331,"UGP2, GCK, HK3, GALE, PGM2, GALK1, PGM1, GALK2, PFKP, GALT, PFKM, PFKL",1.26360349772336,0.480172006224281,FALSE
+"H2009","Input","KEGG_GAP_JUNCTION",-0.45665,-1.45,0.105,7537,0.339,"SOS1, GNAI1, CDK1, TUBB4B, MAPK1, MAPK7, ADCY5, PDGFRA, PDGFRB, TUBA1C, TUBB1, TUBB3, MAP2K5, MAPK3, TUBB, TUBB6, ADCY6, TUBA3C, TUBA1B, TUBB2A, TUBAL3, PLCB4, PLCB2, RAF1, TUBB2B",0.978810700930062,0.469800301796918,FALSE
+"H2009","Input","KEGG_GLIOMA",-0.39128,-1.25,0.189,6980,0.419,"MAP2K1, PRKCB, MTOR, CAMK2B, PIK3CB, PLCG2, MAP2K2, SOS1, PTEN, PIK3R2, MAPK1, ARAF, CDKN1A, PDGFRA, PDGFRB, AKT1, BRAF, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, PLCG1, RAF1, CCND1, RB1",0.723538195826756,0.377785977033705,FALSE
+"H2009","Input","KEGG_GLUTATHIONE_METABOLISM",-0.44793,-1.47,0.0836,8007,0.362,"RRM2B, GCLC, OPLAH, PGD, GGCT, GSTZ1, GSTO1, GSTP1, RRM2, GSTM3, SRM, LAP3, RRM1",1.07779372256098,0.441291429466834,FALSE
+"H2009","Input","KEGG_GLYCEROLIPID_METABOLISM",0.30294,1,0.395,483,0.542,"ALDH1B1, PLPP2, DGKE, PLPP3, GPAT3, GLA",0.40340290437354,0.266000713461613,FALSE
+"H2009","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32367,1.11,0.27,380,0.492,"PEMT, LPCAT1, PLPP2, DGKE, PLA2G12A, CHPT1, PLPP3, GPAT3",0.568636235841013,0.30803489723264,FALSE
+"H2009","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.36317,1.19,0.204,713,0.426,"PIPOX, GATM, MAOA, BHMT",0.690369832574101,0.370590400897281,FALSE
+"H2009","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.44311,-1.41,0.112,6930,0.344,"GCK, BPGM, PKM, HK3, TPI1, PGM2, ALDOA, PGM1, ENO1, LDHA, PCK2, PGAM1, PGAM4, ENO3, PKLR, ACSS2, PGK1, GAPDH, ALDH3A1, PFKP, GPI, PFKM, AKR1A1, ADH5, PFKL",0.950781977329818,0.46344155742847,FALSE
+"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.3152,1.03,0.368,2826,0.536,"CHST11, CHST3, CHST12, XYLT2, DSE, CHST7",0.434152181326482,0.27083521030723,FALSE
+"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.4217,1.35,0.152,2292,0.343,"HS6ST1, EXTL2, HS6ST2, XYLT2",0.818156412055227,0.464705879957229,FALSE
+"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.40924,1.34,0.147,455,0.343,"B4GALT3, B4GALT1",0.832682665251824,0.464705879957229,FALSE
+"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.25099,-0.827,0.669,8293,0.785,"HGSNAT, HYAL1",0.174573882232177,0.105130343254747,FALSE
+"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.77325,-2.45,0.00347,8777,0.127,"ST3GAL2, B4GALNT1",2.45967052520913,0.896196279044043,TRUE
+"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.5863,1.93,0.0186,483,0.235,"B3GALNT1, GLA",1.73048705578208,0.628932137728264,TRUE
+"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.67762,2.25,0.00688,944,0.174,"B3GNT3, B4GALT3, B4GALT1, ST3GAL4",2.16241156176449,0.7594507517174,TRUE
+"H2009","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.51447,-1.64,0.0627,5557,0.338,"PIGT, PIGK, GPAA1, PIGO, PIGH, PIGM, PIGQ, PIGU",1.20273245916928,0.471083299722345,FALSE
+"H2009","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.36586,-1.18,0.256,6932,0.442,"PGP, GRHPR, MDH1, HYI, ACO1, MTHFD1",0.59176003468815,0.354577730650908,FALSE
+"H2009","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.37235,-1.22,0.21,5995,0.419,"ITPR2, CDC42, PRKCD, GNAS, PRKACA, PRKCA, MAP3K3, MAPK9, MAP3K2, ATF4, PLCB3, MAP2K1, MAPK10, PRKCB, CAMK2B, PTK2B, MAP2K2, MAPK14, MAPK12, SOS1, MAP2K7, MAPK1, MAPK8, MAP2K4, MAPK7, MAP3K4, ADCY5, MAPK3, ADCY6, PLCB4, MAP2K3, PLCB2, RAF1",0.677780705266081,0.377785977033705,FALSE
+"H2009","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.4298,-1.4,0.127,8848,0.338,"GSK3B, GLI3",0.896196279044043,0.471083299722345,FALSE
+"H2009","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.56575,1.85,0.0207,819,0.206,"ITGA2B, ITGA6, ITGA3, ITGA4, CD55, ITGA5, ITGA2, EPO, IL1R1",1.68402965454308,0.686132779630847,TRUE
+"H2009","Input","KEGG_HISTIDINE_METABOLISM",0.24155,0.793,0.681,473,0.744,"ALDH1B1, HNMT, MAOA",0.166852888087215,0.128427064454121,FALSE
+"H2009","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.35613,1.19,0.196,3718,0.426,"EME1, RAD51, POLD4, SSBP1, MUS81, RPA3, TOP3A, NBN, POLD3, BRCA2, RAD54L, RPA2, TOP3B, POLD2",0.707743928643524,0.370590400897281,FALSE
+"H2009","Input","KEGG_HUNTINGTONS_DISEASE",0.16114,0.548,0.99,2692,1,"TP53, GPX1, SDHA, RCOR1, POLR2D, NDUFA8, POLR2L, UQCRH, SDHB, POLR2I, SIN3A, POLR2K, CREB5, NDUFS6, POLR2G, UQCRB, CREB1, POLR2J, CLTA, UQCRFS1, NDUFA7, POLR2C, NDUFB1, NDUFA2, NDUFV2, POLR2F, TAF4, UQCRC1, DLG4, VDAC1, POLR2E, NDUFS8, IFT57, NDUFS4, NDUFS5, EP300, HIP1, CLTB, NDUFV3, NDUFB10, NDUFB8, VDAC2, GNAQ, AP2A1",0.00436480540245009,0,FALSE
+"H2009","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.48698,1.57,0.0673,1330,0.225,"ITGB6, TNNC1, ITGB4, ITGA2B, ITGA6, ITGA3, LMNA, ITGA4, ITGB8, ITGA5, ITGA2, ITGAV, TTN, SGCB, TGFB2, CACNA2D1, DAG1",1.17198493577602,0.647817481888638,FALSE
+"H2009","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.51927,-1.65,0.0407,6581,0.347,"PIP4K2B, PI4KB, CDIPT, INPP4A, PLCB3, IMPA2, PIK3CB, MINPP1, TPI1, PLCG2, INPP5B, PTEN, SYNJ1, PIK3C2B, OCRL, PIK3CA, IMPA1, ITPK1, ISYNA1, INPPL1, PIK3C3, PLCG1, PLCB4, INPP1, PLCB2",1.39040559077478,0.459670525209126,FALSE
+"H2009","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.42533,-1.38,0.135,6930,0.333,"GCK, MAP2K1, MAPK10, PHKA1, TSC1, ACACB, RPS6KB1, RPS6, MTOR, HK3, RAPGEF1, PIK3CB, MAP2K2, CRKL, MKNK2, SOS1, RPS6KB2, PRKAG2, PRKAB2, PIK3R2, MAPK1, PCK2, MAPK8, CRK, PHKG2, PRKAB1, ARAF, PRKCZ, PHKB, MKNK1, GYS1, PKLR, CBL, AKT1, BRAF, PRKCI, MAPK3, PPP1R3D, PRKAA1, PIK3CA, TSC2, GSK3B, PIK3R1, AKT2, PRKAG1, SOCS2, CBLB, IKBKB, FOXO1, EIF4EBP1, RAF1",0.869666231504994,0.47755576649368,FALSE
+"H2009","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.38142,-1.23,0.212,8592,0.421,"ICOSLG, CXCR4",0.673664139071249,0.375717904164332,FALSE
+"H2009","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.34591,-1.08,0.324,8325,0.481,"CBL, AKT1, PTPN11, PIK3CA, PIK3R1, STAT6, AKT2, SOCS2, CBLB, STAT2, PIAS4, CCND1, SPRY4",0.489454989793388,0.317854923626168,FALSE
+"H2009","Input","KEGG_LEISHMANIA_INFECTION",-0.30183,-0.948,0.458,6703,0.614,"STAT1, PTPN6, MAP3K7, PRKCB, IRAK4, C3, NFKBIB, NFKB1, MAPK14, MAPK12, MAPK1, IL1A, MYD88, RELA, TGFB3, MAPK3, TAB2, TRAF6",0.339134521996131,0.211831628858832,FALSE
+"H2009","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.29643,0.968,0.44,958,0.542,"ITGB2, RAC2, CLDN7, F11R, CTNNB1, SIPA1, CTNND1, ITGA4, CTNNA1, CTNNA2, PIK3R3, CD99, ACTN4, ICAM1, PIK3CD",0.356547323513813,0.266000713461613,FALSE
+"H2009","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.37952,1.24,0.21,2597,0.397,"ALDH1B1, ECHS1, HADHA, ALDH2, ALDH7A1, ALDH3A2",0.677780705266081,0.401209493236885,FALSE
+"H2009","Input","KEGG_LONG_TERM_DEPRESSION",-0.27573,-0.882,0.58,6833,0.7,"PLCB3, PPP2CA, MAP2K1, PRKCB, GUCY1A1, MAP2K2, GNAI1, PPP2R1B, MAPK1, GNA12, ARAF, BRAF, MAPK3, PPP2CB, PLCB4, GNA13, PLCB2, RAF1",0.236572006437063,0.154901959985743,FALSE
+"H2009","Input","KEGG_LONG_TERM_POTENTIATION",-0.29808,-0.952,0.484,6292,0.614,"PRKACA, PRKCA, ATF4, PPP3CC, PLCB3, MAP2K1, PRKCB, CAMK2B, MAP2K2, MAPK1, ARAF, BRAF, MAPK3, PLCB4, PLCB2, RAF1",0.315154638355588,0.211831628858832,FALSE
+"H2009","Input","KEGG_LYSINE_DEGRADATION",0.4429,1.5,0.0874,2236,0.237,"PIPOX, ALDH1B1, NSD2, ACAT1, ECHS1, DOT1L, PLOD2, EHMT1, HADH, HADHA, ASH1L, ALDH2, SETD2, AASS, DLST, SUV39H1, ALDH7A1",1.0584885673656,0.625251653989896,FALSE
+"H2009","Input","KEGG_LYSOSOME",-0.20063,-0.627,0.913,7680,0.975,"SMPD1, ATP6V1H, AP3M2, CLN3, MANBA, GALC, AP3B1, AP1M1, HGSNAT, HYAL1, AP3M1, AP3S2, AP4E1, AP4M1, AP3S1, AP3D1, CTSG, CLN5",0.039529222465701,0.0109953843014632,FALSE
+"H2009","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.3404,-1.08,0.325,7329,0.481,"MAP2K2, IKBKG, CRKL, NFKB1, HSPB1, MAPK14, MAPK12, MKNK2, SOS1, MAP2K7, CASP3, MAP4K2, TRAF2, RAPGEF2, NFATC2, MAP3K20, MAPK1, MAPK8, GNA12, MAP2K4, CRK, MAPK7, MAP3K4, IL1A, MKNK1, PDGFRA, MAPKAPK2, RELA, PDGFRB, RASA2, AKT1, BRAF, TGFB3, MAP2K5, MAPK3, FGFR2, PPM1A, DUSP3, MEF2C, NLK, NFKB2, TAB2, STK4, TRAF6, AKT2, STMN1, IKBKB, PPP5C, MAP2K3, FGFR1, RAF1",0.488116639021126,0.317854923626168,FALSE
+"H2009","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.44743,-1.45,0.107,6930,0.339,"GCK, IAPP, PKLR, MNX1",0.97061622231479,0.469800301796918,FALSE
+"H2009","Input","KEGG_MELANOGENESIS",-0.25611,-0.815,0.669,6744,0.782,"MITF, PLCB3, MAP2K1, PRKCB, CAMK2B, DCT, MAP2K2, DVL3, GNAI1, MAPK1, ADCY5, MAPK3, ADCY6, GSK3B, PLCB4, PLCB2, RAF1",0.174573882232177,0.106793246940152,FALSE
+"H2009","Input","KEGG_MELANOMA",-0.3888,-1.26,0.171,7715,0.415,"PTEN, PIK3R2, MAPK1, ARAF, CDKN1A, PDGFRA, PDGFRB, AKT1, BRAF, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, FGFR1, RAF1, CCND1, RB1",0.767003889607846,0.381951903287907,FALSE
+"H2009","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.52225,-1.68,0.0432,7659,0.385,"AKR1C1, AKR1C3, GSTT2, ALDH3A1, GSTZ1, GSTO1, GSTP1, GSTM3, ADH5",1.36451625318509,0.414539270491499,FALSE
+"H2009","Input","KEGG_MISMATCH_REPAIR",0.55276,1.81,0.0352,3899,0.177,"POLD4, RFC4, SSBP1, RFC1, RFC2, MSH6, RPA3, MSH2, RFC3, MLH1, RFC5, PMS2, POLD3, RPA2, PCNA, POLD2, RPA1, LIG1",1.45345733652187,0.752026733638193,TRUE
+"H2009","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.53238,-1.73,0.0479,7054,0.349,"TSC1, RPS6KB1, RPS6, MTOR, PIK3CB, RPS6KB2, STK11, PIK3R2, MAPK1, EIF4B, AKT1, BRAF, MAPK3, PRKAA1, PIK3CA, CAB39L, TSC2, STRADA, PIK3R1, AKT2, EIF4EBP1",1.31966448658544,0.45717457304082,FALSE
+"H2009","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.35859,1.16,0.226,958,0.456,"ITGB2, RAC2, RAET1L, ULBP2, ULBP3, MICA, MICB, PIK3R3, HRAS, ICAM2, ICAM1, KRAS, NRAS, PIK3CD",0.645891560852599,0.341035157335565,FALSE
+"H2009","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.41258,-1.32,0.162,5764,0.358,"HTR2B, NR3C1, F2, PLG, TACR1, CHRNE, PRSS1, F2R, HCRTR1, TSPO, P2RX4, CTSG",0.790484985457369,0.446116973356126,FALSE
+"H2009","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.4355,-1.38,0.139,6980,0.333,"MAP2K1, YWHAE, MAPK10, IRAK4, CAMK2B, RAPGEF1, PIK3CB, NFKBIB, PLCG2, MAP2K2, CRKL, NFKB1, YWHAB, MAPK14, MAPK12, SOS1, MAP2K7, RIPK2, ABL1, PIK3R2, MAPK1, YWHAQ, MAPK8, YWHAG, ARHGDIA, CRK, MAPK7, FOXO3, NFKBIE, MAPKAPK2, BAX, RELA, AKT1, BRAF, NGFR, MAP2K5, MAPK3, PTPN11, PIK3CA, TRAF6, GSK3B, PIK3R1, AKT2, PLCG1, IKBKB, CSK, RAF1",0.856985199745905,0.47755576649368,FALSE
+"H2009","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.34527,-1.1,0.314,6958,0.466,"NT5C3A, NT5C2, NADSYN1, NT5C, PNP, NAMPT, NNMT, NMRK1",0.503070351926785,0.33161408331,FALSE
+"H2009","Input","KEGG_NITROGEN_METABOLISM",-0.45186,-1.46,0.106,8377,0.363,"CA1, CA12, CA9, ASNS, CPS1, CA8",0.97469413473523,0.440093374963888,FALSE
+"H2009","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.56179,-1.79,0.0249,6749,0.421,"MAP3K7, SUGT1, MAPK10, NFKBIB, IKBKG, TRIP6, NFKB1, MAPK14, BIRC2, MAPK12, CASP8, CASP1, RIPK2, MAPK1, MAPK8, HSP90AB1, CARD6, IL18, HSP90AA1, RELA, PYCARD, MAPK3, CCL13, TAB2, TRAF6, IKBKB",1.60380065290426,0.375717904164332,FALSE
+"H2009","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.257,-0.801,0.643,8909,0.798,"NHEJ1",0.191789027075778,0.0979971086492706,FALSE
+"H2009","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.34885,-1.1,0.279,6980,0.466,"MAP2K1, PRKCB, PIK3CB, CASP9, PLCG2, MAP2K2, SOS1, PIK3R2, MAPK1, FOXO3, ARAF, AKT1, BRAF, MAPK3, PIK3CA, CDK6, STK4, PIK3R1, AKT2, PLCG1, RAF1, CCND1, RB1",0.554395796726402,0.33161408331,FALSE
+"H2009","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.38446,1.27,0.172,2904,0.384,"NOTCH3, DTX2, HES1, CTBP1, JAG1, DVL1, CTBP2, RBPJ, DTX3L, NUMB, EP300, NCOR2, SNW1, CREBBP",0.764471553092451,0.415668775632469,FALSE
+"H2009","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.26599,0.878,0.555,3545,0.663,"ERCC5, ERCC8, GTF2H5, MNAT1, POLD4, RFC4, GTF2H1, RFC1, RFC2, RPA3, RFC3, RFC5, RBX1, RAD23B, POLD3, POLE3, CUL4A, GTF2H2, RPA2, PCNA",0.255707016877324,0.178486471595227,FALSE
+"H2009","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.24801,0.831,0.633,2528,0.701,"B4GALT3, B4GALT1, TUSC3, ALG2, ALG10, ALG10B, MAN2A1, FUT8, MGAT2, MAN1A1, MOGS, MAN2A2",0.198596289982645,0.154281982033341,FALSE
+"H2009","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.42598,-1.37,0.135,6177,0.336,"PRKG1, PRKACA, ARRB2, CAMK2B, CLCA2",0.869666231504994,0.473660722610156,FALSE
+"H2009","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.51467,-1.66,0.061,8150,0.358,"TYMS, DHFR, ATIC, GART, MTHFD1, MTHFR",1.21467016498923,0.446116973356126,FALSE
+"H2009","Input","KEGG_OOCYTE_MEIOSIS",-0.35419,-1.13,0.261,5425,0.459,"CCNB2, ANAPC4, PRKACB, ANAPC7, PKMYT1, PPP3CB, CDK2, MOS, PPP1CA, CDC25C, CDC23, RPS6KA1, FBXW11, ITPR2, YWHAH, ESPL1, CUL1, PRKACA, YWHAZ, PPP2R1A, MAD2L1, CCNB1, PPP3CC, PPP2CA, MAP2K1, YWHAE, PPP2R5C, CAMK2B, YWHAB, MAPK12, PPP2R1B, CDK1, FBXO5, MAPK1, PPP2R5B, YWHAQ, YWHAG, ADCY5, PPP2R5E, MAPK3, ADCY6, PPP2CB, STAG3, PPP2R5A, PPP2R5D, PTTG1",0.583359492661719,0.338187314462739,FALSE
+"H2009","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.26005,0.857,0.592,301,0.678,"NEU1",0.22767829327708,0.168770306132937,FALSE
+"H2009","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.087514,-0.281,1,5656,1,"ATP6V1G2, NDUFA6, NDUFC2, ATP6V0A1, NDUFB5, NDUFA9, COX7A2, ATP5F1A, NDUFA4, ATP6V0C, NDUFS7, ATP5F1C, ATP6V1C2, ATP6V1D, ATP5PB, ATP6V1E1, ATP6V1G1, NDUFAB1, ATP5MG, COX6C, ATP6V1H, ATP6V1B2, LHPP, ATP6V1B1, ATP6V1A, ATP6V1C1, PPA1",0,0,FALSE
+"H2009","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.52575,1.71,0.0501,373,0.202,"GALNT3, GALNT6, GALNT12, GALNT13, GALNT15, GALNT7",1.30016227413275,0.694648630553376,FALSE
+"H2009","Input","KEGG_P53_SIGNALING_PATHWAY",-0.36936,-1.17,0.246,7610,0.447,"CCND3, CASP8, CASP3, CDK1, PTEN, RRM2B, SIAH1, CDKN1A, APAF1, BAX, SESN2, DDB2, CDK6, TSC2, SERPINE1, RRM2, CCND1",0.609064892896621,0.349692476868064,FALSE
+"H2009","Input","KEGG_PANCREATIC_CANCER",-0.27715,-0.878,0.576,7828,0.7,"PIK3R2, MAPK1, MAPK8, ARAF, SMAD2, RELA, AKT1, BRAF, TGFB3, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, IKBKB, RAF1, CCND1, RB1",0.239577516576788,0.154901959985743,FALSE
+"H2009","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.62371,-1.99,0.015,7354,0.295,"PPCDC, PANK2, PANK4, DPYD, PPCS",1.82390874094432,0.530177984021837,FALSE
+"H2009","Input","KEGG_PARKINSONS_DISEASE",0.13281,0.432,0.998,3435,1,"SDHA, UBE2J1, UBE2G2, NDUFA8, UQCRH, SDHB, HTRA2, NDUFS6, UBE2J2, UQCRB, UQCRFS1, NDUFA7, NDUFB1, NDUFA2, NDUFV2, UQCRC1, VDAC1, NDUFS8, NDUFS4, NDUFS5, NDUFV3, LRRK2, NDUFB10, NDUFB8, VDAC2, NDUFA5, NDUFS1, UQCRC2, NDUFA3, NDUFV1, NDUFA10, NDUFB9, SDHD, COX5A, SLC25A5, COX7A2L, NDUFS3, SNCA, SLC25A4",0.000869458712628891,0,FALSE
+"H2009","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.50904,-1.63,0.0488,7773,0.332,"TUBB4B, ABL1, YWHAQ, ROCK2, TUBA1C, TUBB1, TUBB3, TUBB, TUBB6, TUBA3C, TUBA1B, TUBB2A, TUBAL3, TUBB2B, CLDN1, WAS",1.31158017799729,0.478861916295964,FALSE
+"H2009","Input","KEGG_PATHWAYS_IN_CANCER",-0.22836,-0.742,0.788,7329,0.843,"MAP2K2, IKBKG, DVL3, CRKL, STAT5A, NFKB1, BIRC2, HGF, SOS1, PTK2, CASP8, CASP3, TRAF2, PTEN, ABL1, PIK3R2, PIAS2, MAPK1, MAPK8, CRK, HSP90AB1, EGLN1, ARAF, CDKN1A, CUL2, SMAD2, PDGFRA, HSP90AA1, BAX, RELA, PDGFRB, CBL, AKT1, BRAF, FADD, TGFB3, MAPK3, FGFR2, PIK3CA, NFKB2, TFG, CDK6, STK4, TRAF6, GSK3B, PIK3R1, GSTP1, DAPK1, AKT2, PLCG1, CEBPA, CBLB, IKBKB, CDKN1B, FOXO1, PIAS4, FGFR1, COL4A1, RAF1, CCND1, RB1, GLI3",0.103473782510445,0.0741724253752577,FALSE
+"H2009","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.48909,-1.62,0.0611,5337,0.325,"AKR1B1, UGT2B11, UGT2B4, DCXR, GUSB, UGP2, RPE, XYLB, CRYL1",1.21395878975745,0.488116639021126,FALSE
+"H2009","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.57749,-1.83,0.0256,7160,0.41,"PRPS2, PGM2, ALDOA, RBKS, PGM1, PRPS1, PRPS1L1, RPE, PGLS, DERA, TALDO1, PGD, PFKP, GPI, PFKM, PFKL",1.59176003468815,0.387216143280265,FALSE
+"H2009","Input","KEGG_PEROXISOME",0.30176,0.982,0.411,2320,0.53,"PIPOX, ACAA1, SLC25A17, ACOX1, PEX2, AGPS, PECR, PEX6, ABCD1, PEX26, ACSL4, PEX1, PEX13, ECI2, SCP2, ACSL3, FAR1, CROT, GSTK1, HSD17B4, HACL1, HMGCL, ACOT8",0.386158178123931,0.275724130399211,FALSE
+"H2009","Input","KEGG_PHENYLALANINE_METABOLISM",-0.33871,-1.07,0.328,6402,0.482,"TAT, MAOB, DDC, MIF, PRDX6, NAA80, ALDH3A1",0.484126156288321,0.31695296176115,FALSE
+"H2009","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.44934,-1.44,0.088,6581,0.34,"PIP4K2B, PI4KB, CDIPT, INPP4A, PLCB3, IMPA2, PRKCB, DGKZ, PIK3CB, DGKA, PLCG2, INPP5B, PTEN, PIK3R2, DGKB, SYNJ1, PIK3C2B, OCRL, PIK3CA, IMPA1, ITPK1, PIK3R1, INPPL1, PIK3C3, PLCG1, PLCB4, INPP1, DGKH, PLCB2",1.05551732784983,0.468521082957745,FALSE
+"H2009","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.29433,-0.934,0.482,7805,0.623,"BLVRB, CP, HMBS, UROD, BLVRA, UROS",0.31695296176115,0.20551195334083,FALSE
+"H2009","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.36098,1.19,0.237,1984,0.426,"FADS2, CYP27A1, ACADM, MMP1, ACAA1, APOA1, ACOX1, CPT2, ACSL4, SORBS1, SLC27A4, SCP2, ACSL3, FABP2, RXRA, APOC3",0.625251653989896,0.370590400897281,FALSE
+"H2009","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45448,1.49,0.0966,2446,0.235,"CYP27A1, SCP2, HSD17B4, AMACR",1.01502287358451,0.628932137728264,FALSE
+"H2009","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.17553,0.573,0.974,933,1,"RFXAP, RFXANK",0.0114410431213845,0,FALSE
+"H2009","Input","KEGG_PRION_DISEASES",-0.48858,-1.55,0.0663,6110,0.313,"PRNP, PRKACA, STIP1, NCAM2, MAP2K1, MAP2K2, C9, MAPK1, IL1A, BAX, MAPK3, SOD1, NCAM1",1.17848647159523,0.504455662453552,FALSE
+"H2009","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.30465,-0.971,0.427,7495,0.603,"MAPK14, MAPK12, GNAI1, CDK1, PIK3R2, MAPK1, MAPK8, HSP90AB1, ARAF, ADCY5, HSP90AA1, AKT1, BRAF, MAPK3, ADCY6, PIK3CA, PIK3R1, AKT2, RAF1",0.369572124974976,0.219682687859849,FALSE
+"H2009","Input","KEGG_PROPANOATE_METABOLISM",0.42598,1.37,0.111,2236,0.332,"ACADM, ALDH1B1, ACSS3, MCEE, ACAT1, ECHS1, HADHA, PCCB, SUCLG2, ALDH2, PCCA, SUCLG1, ALDH7A1",0.954677021213343,0.478861916295964,FALSE
+"H2009","Input","KEGG_PROSTATE_CANCER",-0.41227,-1.32,0.162,7178,0.358,"MTOR, PIK3CB, CASP9, MAP2K2, IKBKG, NFKB1, SOS1, PTEN, PIK3R2, MAPK1, HSP90AB1, ARAF, CDKN1A, PDGFRA, HSP90AA1, RELA, PDGFRB, AKT1, BRAF, MAPK3, FGFR2, PIK3CA, GSK3B, PIK3R1, GSTP1, AKT2, IKBKB, CDKN1B, FOXO1, FGFR1, RAF1, CCND1, RB1",0.790484985457369,0.446116973356126,FALSE
+"H2009","Input","KEGG_PROTEASOME",-0.20163,-0.645,0.906,2341,0.965,"PSMD4, PSME3, PSMB10, PSMB6, PSMC5, PSMB7, PSMC6, PSMC3, PSMC4, PSMA1, PSMC2, PSMD14, PSMA4, PSMB9, PSMB2, PSMB3, PSMB4, PSMC1, PSMA3, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB5, PSMA2, PSME4, PSMD2, PSMD11, PSMD6, PSMD7, PSMD13, PSMD1, PSMD8, SEM1, PSMD12, PSMD3, POMP, PSME1, PSME2, PSMF1",0.0428718023231869,0.0154726866562074,FALSE
+"H2009","Input","KEGG_PROTEIN_EXPORT",-0.23798,-0.772,0.739,5254,0.833,"SEC63, SRP68, SRPRB, SPCS1, OXA1L, SRP14, SEC61B, SEC61A1, SRP19, SRP54, SEC11C",0.131355561605174,0.0793549985932124,FALSE
+"H2009","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.39199,1.28,0.172,1189,0.384,"GLUD2, ATP1A2, ATP1B1, GLS, GLS2",0.764471553092451,0.415668775632469,FALSE
+"H2009","Input","KEGG_PURINE_METABOLISM",-0.29485,-0.983,0.467,6958,0.59,"NT5C3A, GMPS, PKM, PRPS2, NUDT9, GUCY1A1, NT5C2, DCK, GMPR2, PDE5A, PDE2A, NT5C, PAICS, PNP, PRPS1, PRPS1L1, PDE8A, XDH, RRM2B, HPRT1, IMPDH2, ADCY5, PKLR, NME3, ADSL, ADCY6, ATIC, NME1, APRT, NUDT5, GART, ADA, AMPD2, ITPA, RRM2, PFAS, RRM1, NUDT2",0.330683119433888,0.229147988357856,FALSE
+"H2009","Input","KEGG_PYRIMIDINE_METABOLISM",-0.23517,-0.749,0.764,7236,0.857,"NT5C2, DCK, UPP1, NT5C, DPYD, PNP, DUT, CTPS2, RRM2B, TYMS, DCTD, NME3, CAD, UPRT, NME1, UMPS, CTPS1, ITPA, RRM2, RRM1, NUDT2",0.11690664142431,0.0670191780768018,FALSE
+"H2009","Input","KEGG_PYRUVATE_METABOLISM",-0.22973,-0.732,0.808,6465,0.852,"HAGHL, ACSS1, ACACA, GRHPR, PKM, HAGH, ACACB, ACAT2, ACYP1, LDHA, PCK2, MDH1, PKLR, ACSS2",0.0925886392254138,0.0695604052332999,FALSE
+"H2009","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.23404,-0.748,0.743,6428,0.85,"ARPC4, ACTG1, ARHGEF6, GIT1, IQGAP1, PIP4K2B, ARPC1A, ITGA1, VAV3, MSN, CFL1, WASL, SSH1, DIAPH1, MAP2K1, ARHGEF7, PAK3, MYH14, ROCK1, PXN, PIK3CB, CYFIP2, F2R, PAK2, MAP2K2, CRKL, LIMK2, IQGAP3, MYH10, SOS1, PTK2, ARHGEF1, MYH9, CYFIP1, PIK3R2, MAPK1, VAV2, GNA12, CRK, ROCK2, ARAF, PDGFRA, ITGB3, PFN1, PDGFRB, BRAF, MAPK3, DIAPH3, FGFR2, VCL, PIK3CA, SSH3, ARHGAP35, PIK3R1, DOCK1, GNA13, CSK, FGFR1, RAF1, WAS",0.129011186239425,0.0705810742857073,FALSE
+"H2009","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.62889,-2.01,0.00526,8159,0.334,"ATG7, ATG4B, PRKAA1, PIK3R4, PIK3C3, ATG3",2.27901425584626,0.476253533188435,FALSE
+"H2009","Input","KEGG_RENAL_CELL_CARCINOMA",-0.3157,-1.02,0.382,6980,0.544,"MAP2K1, PAK3, RAPGEF1, PIK3CB, PAK2, MAP2K2, CRKL, HGF, SOS1, PIK3R2, MAPK1, CRK, EGLN1, FLCN, ARAF, CUL2, AKT1, BRAF, TGFB3, MAPK3, PTPN11, PIK3CA, PIK3R1, AKT2, RAF1",0.417936637088291,0.26440110030182,FALSE
+"H2009","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.58364,-1.91,0.0223,8618,0.346,"MME, ACE, CTSG, ACE2",1.65169513695184,0.460923901207223,FALSE
+"H2009","Input","KEGG_RETINOL_METABOLISM",-0.38306,-1.22,0.22,9074,0.419,"ADH5, ALDH1A1",0.657577319177794,0.377785977033705,FALSE
+"H2009","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.35905,-1.14,0.282,6823,0.467,"ACP2, RFK, ACP1, PHPT1, MTMR2, MTMR6",0.549750891680639,0.330683119433888,FALSE
+"H2009","Input","KEGG_RIBOSOME",-0.6532,-2.1,0.0121,6319,0.436,"RPL35, RPLP0, RPS4Y1, RPL23, RPL22L1, RPS15A, RPL23A, RPL36, RPL24, RSL24D1, RPL22, RPS7, RPL3, RPS19, RPL17, RPS8, RPL10, RPL15, RPS6, RPS15, RPL5, RPS4X, RPL7, RPS20, RPL30, RPS17, RPL31, RPS3, RPS24, RPS3A, RPL18A, RPL9, RPL27A, RPS25, RPS26, RPL35A, RPS5, RPL10A, RPL27, RPS13, RPL8, RPL4, RPL37A, RPL18, RPL21, RPL26, RPS2, RPL32, RPL29, RPS16, RPL6, RPL7A, RPL13A, RPL14, RPL28, RPS9, RPL37, RPS10, RPS18, RPL34, UBA52, RPL19, RPS11, FAU, RPS27L, RPS23, RPL36A, RPL36AL, RPL38, RPL26L1",1.91721462968355,0.360513510731414,FALSE
+"H2009","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.55481,-1.76,0.0357,6379,0.376,"ATG5, MAPK9, MAVS, TRAF3, MAP3K7, TRIM25, MAPK10, NFKBIB, DHX58, IKBKG, TBKBP1, NFKB1, MAPK14, MAPK12, CASP8, TANK, TRAF2, IRF3, MAPK8, DDX58, RIPK1, TBK1, RELA, FADD, PIN1, DDX3Y, TRAF6, CYLD, IKBKB, TKFC",1.44733178388781,0.424812155072339,FALSE
+"H2009","Input","KEGG_RNA_DEGRADATION",-0.17392,-0.564,0.962,6984,0.984,"CNOT4, CNOT6L, XRN1, CNOT7, XRN2, DCP2, DIS3, ENO1, PATL1, LSM1, ENO3, TTC37, SKIV2L, DCP1B",0.0168249279621871,0.00700490156865849,FALSE
+"H2009","Input","KEGG_RNA_POLYMERASE",0.4584,1.5,0.0979,3369,0.237,"POLR2D, POLR2L, POLR1E, POLR2I, POLR2K, POLR2G, POLR3K, POLR2J, POLR2C, POLR2F, POLR2E, POLR3H, POLR3F, POLR3D, POLR1C, POLR1D, POLR2A, POLR2H",1.00921730819686,0.625251653989896,FALSE
+"H2009","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.38989,-1.21,0.225,5400,0.416,"MAT2B, GGT1, TRMT11, SEPHS2, AHCYL1, AHCYL2, PAPSS2, MAT2A, BUD23, METTL2B, CTH, SCLY, MAT1A, LCMT1, AHCY, CBS, LCMT2",0.647817481888638,0.380906669373257,FALSE
+"H2009","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.31011,1.04,0.377,586,0.532,"LAMC2, TP53, ITGA2B, LAMB3, ITGA6, ITGA3, LAMA3, LAMA4, PIK3R3, ITGA2, LAMB1, ITGAV",0.423658649794207,0.274088367704952,FALSE
+"H2009","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.29441,0.958,0.467,2020,0.548,"VAMP8, GOSR1, STX17, VAMP4, STX10, STX6, GOSR2, STX12",0.330683119433888,0.261219441515631,FALSE
+"H2009","Input","KEGG_SPHINGOLIPID_METABOLISM",0.48509,1.63,0.0462,483,0.246,"PLPP2, NEU1, UGT8, PLPP3, GLA",1.33535802444387,0.609064892896621,TRUE
+"H2009","Input","KEGG_SPLICEOSOME",0.5245,1.74,0.0414,2839,0.194,"ISY1, PHF5A, HNRNPA3, SNRNP70, SRSF1, SNRPB, PRPF4, PRPF40B, SF3B4, HNRNPC, SNRPC, U2AF1, PPIE, SNRPG, U2AF2, SRSF9, NCBP2, SNRPD3, TRA2A, SF3B5, SNRPF, DHX8, TCERG1, PUF60, THOC3, SRSF10, RBM25, SRSF3, SF3B2, PRPF40A, SRSF7, LSM8, SRSF8, PRPF3, DDX5, LSM4, SF3B6, RBMX, TRA2B, LSM6, SNRPA1, SNRPA, HNRNPA1, SRSF4, SF3A1, HNRNPK, DDX23, SF3B1, SRSF5, BCAS2, U2SURP, DDX46, SRSF6, LSM7, DHX38, PPIH, ALYREF, DDX42, PRPF19, ZMAT2, RBM17, RBM8A, SNRNP40, PQBP1, SNRPB2, THOC1, LSM2, HSPA1L, SF3A3, SRSF2, PRPF38A, SNW1, SF3B3",1.3829996588791,0.712198270069774,TRUE
+"H2009","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.389,-1.24,0.199,5667,0.416,"UGT2B11, UGT2B4, PYGB, GUSB, AGL, PYGL, UGP2, GCK, HK3, PGM2, PGM1, GYS1, GBE1, GPI",0.701146923590293,0.380906669373257,FALSE
+"H2009","Input","KEGG_STEROID_BIOSYNTHESIS",0.4863,1.62,0.0605,1862,0.226,"MSMO1, SOAT1, FDFT1, HSD17B7, SQLE, CYP27B1, DHCR24, NSDHL",1.21824462534753,0.645891560852599,FALSE
+"H2009","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.34609,-1.12,0.308,7659,0.465,"AKR1C1, AKR1C3, AKR1D1, CYP21A2",0.511449283499556,0.332547047110046,FALSE
+"H2009","Input","KEGG_SULFUR_METABOLISM",0.47416,1.58,0.0698,2177,0.229,"CHST11, SULT1A3, CHST12, PAPSS1",1.15614457737684,0.640164517660112,FALSE
+"H2009","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.27638,-0.883,0.55,7154,0.706,"C3, C9, C4A, TRIM21, CTSG",0.259637310505756,0.151195298948196,FALSE
+"H2009","Input","KEGG_TASTE_TRANSDUCTION",-0.3025,-0.967,0.45,8567,0.603,"ADCY6, PLCB2",0.346787486224656,0.219682687859849,FALSE
+"H2009","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.47856,-1.57,0.0664,6679,0.332,"FDPS, PMVK, MVK, ACAT2, IDI1, MVD, GGPS1",1.17783192063198,0.478861916295964,FALSE
+"H2009","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.32172,-1.02,0.362,6779,0.544,"ZFYVE16, BMPR2, PPP2CA, ROCK1, RPS6KB1, ID3, AMH, RPS6KB2, PPP2R1B, MAPK1, ROCK2, SMAD2, SMAD5, SMAD9, SMAD1, TGFB3, MAPK3, PPP2CB",0.441291429466834,0.26440110030182,FALSE
+"H2009","Input","KEGG_THYROID_CANCER",0.38556,1.24,0.18,1410,0.397,"TP53, CTNNB1, CDH1, HRAS, KRAS, NRAS, NCOA4, TPR, MYC",0.744727494896694,0.401209493236885,FALSE
+"H2009","Input","KEGG_TIGHT_JUNCTION",0.30393,1,0.365,1297,0.542,"CLDN7, CGN, F11R, CTNNB1, AMOTL1, CTNNA1, TJP3, CTNNA2, CASK, MYH2, MPDZ, PATJ, HRAS, TJP1, VAPA, SPTAN1, ACTN4, KRAS, NRAS, LLGL2, TJP2, AFDN, RAB3B, ASH1L",0.437707135543525,0.266000713461613,FALSE
+"H2009","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.48209,-1.56,0.0701,6703,0.328,"STAT1, TRAF3, MAP3K7, SPP1, MAP2K1, MAPK10, IRAK4, PIK3CB, MAP2K2, IKBKG, NFKB1, MAPK14, MAPK12, MAP2K7, CASP8, IRF3, PIK3R2, MAPK1, MAPK8, MAP2K4, MYD88, RIPK1, TBK1, RELA, AKT1, FADD, MAPK3, PIK3CA, TAB2, TRAF6, PIK3R1, AKT2, IKBKB, MAP2K3",1.15428198203334,0.484126156288321,FALSE
+"H2009","Input","KEGG_TRYPTOPHAN_METABOLISM",0.32458,1.07,0.324,1258,0.506,"ALDH1B1, MAOA, ACAT1, ECHS1, HADH, HADHA",0.489454989793388,0.295849483160201,FALSE
+"H2009","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.44209,-1.45,0.102,6930,0.339,"GCK, PKM, MAPK10, MTOR, HK3, PIK3CB, PIK3R2, MAPK1, MAPK8, PRKCZ, PKLR, MAPK3, PIK3CA, PIK3R1, SOCS2, IKBKB",0.991399828238082,0.469800301796918,FALSE
+"H2009","Input","KEGG_TYROSINE_METABOLISM",-0.52439,-1.67,0.0403,6402,0.371,"TAT, MAOB, FAH, BUD23, METTL2B, DDC, DCT, MIF, PNMT, LCMT1, NAA80, ALDH3A1, GSTZ1, ADH5, LCMT2",1.39469495385889,0.430626090384954,FALSE
+"H2009","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.43728,-1.4,0.134,6633,0.338,"BCL10, VAV3, PPP3CC, PTPN6, MAP3K7, NCK2, MAP2K1, PAK3, PIK3CB, NFKBIB, PAK2, MAP2K2, NCK1, IKBKG, PRKCQ, NFKB1, MAPK14, MAPK12, SOS1, MAP2K7, NFATC2, PIK3R2, MAPK1, VAV2, NFKBIE, RELA, CBL, AKT1, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, PLCG1, MALT1, CBLB, IKBKB, RAF1",0.872895201635192,0.471083299722345,FALSE
+"H2009","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.3559,-1.15,0.27,7777,0.46,"UBE2O, PIAS2, UBE2M, CDC34, UBE2L3, SIAH1, FBXW8, CUL2, BIRC6, NEDD4L, CUL7, UBE2R2, UBE2G1, NEDD4, CBL, HERC1, UBE2D2, UBE2N, DDB2, UBE3C, UBE2E1, UBE2D4, UBA1, TRAF6, UBE2NL, HERC4, UBE3B, CBLB, UBE3A, PIAS4",0.568636235841013,0.337242168318426,FALSE
+"H2009","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.48592,1.61,0.0591,1659,0.221,"PDHA1, PDHB, BCAT2",1.22841251911874,0.655607726314889,FALSE
+"H2009","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.58129,1.92,0.0265,2597,0.209,"ACADM, ALDH1B1, OXCT1, ACAA1, DBT, MCEE, ACAT1, ECHS1, HADHB, HADH, HADHA, MCCC2, PCCB, ACADSB, BCAT2, ALDH2, PCCA, AUH, ALDH7A1, BCKDHA, HMGCL, BCKDHB, ALDH3A2",1.57675412606319,0.679853713888946,TRUE
+"H2009","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.46886,-1.55,0.0787,5982,0.313,"ARHGEF11, ITPR2, PRKCD, PRKG1, MYL6, ARHGEF12, GNAS, PRKACA, PRKCA, PLCB3, MAP2K1, PRKCB, ROCK1, GUCY1A1, MAP2K2, PRKCQ, ARHGEF1, MAPK1, GNA12, ROCK2, ARAF, MYH11, ADCY5, BRAF, KCNMA1, MAPK3, ADCY6, CALD1, PLCB4, GNA13, PLCB2, RAF1",1.10402526764094,0.504455662453552,FALSE
+"H2009","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.35698,-1.16,0.244,7018,0.453,"DYNC2LI1, DCTN4, DCTN5, DCTN6, ARHGDIA, DCTN2, DYNC1LI2, DCTN1, DYNC1I2, ADCY6, DYNC1LI1, DYNC1H1",0.612610173661271,0.343901797987168,FALSE
+"H2009","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.30473,-0.962,0.44,6980,0.604,"MAP2K1, PRKCB, PXN, PIK3CB, CASP9, PLCG2, MAP2K2, HSPB1, MAPK14, MAPK12, PTK2, NFATC2, PIK3R2, MAPK1, MAPKAPK2, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, RAF1",0.356547323513813,0.218963061378868,FALSE
+"H2009","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.37068,-1.2,0.215,6251,0.422,"GNAS, ATP6V0C, PRKACA, PRKCA, ACTG1, SEC61B, ATP6V1C2, ATP6V1D, SEC61A1, SLC12A2, PRKCB, ATP6V1E1, ATP6V1G1, PLCG2, ATP6V1H, ATP6V1B2, ATP6V1B1, ATP6V1A, ATP6V1C1, PLCG1",0.667561540084395,0.374687549038326,FALSE
+"H2009","Input","KEGG_VIRAL_MYOCARDITIS",0.30864,1.01,0.408,425,0.546,"ITGB2, RAC2, CD55, MYH2",0.38933983691012,0.262807357295263,FALSE
+"H2009","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.18723,-0.6,0.967,6125,0.971,"WNT5A, DVL2, SMAD4, CUL1, PRKACA, PRKCA, NFAT5, CSNK2A1, CSNK2A2, MAPK9, PPP2R1A, PPP3CC, MAP3K7, PLCB3, PPP2CA, MAPK10, PRKCB, CACYBP, ROCK1, PPP2R5C, CAMK2B, DVL3, PPP2R1B, CCND3, NFATC2, PPP2R5B, MAPK8, ROCK2, SIAH1, SMAD2, PPP2R5E, PPP2CB, NLK, PPP2R5A, GSK3B, PPP2R5D, PLCB4, PLCB2, CCND1",0.0145735259169983,0.0127807700919951,FALSE
+"H2126","Input","KEGG_ABC_TRANSPORTERS",0.59912,1.75,0.023,1103,0.201,"ABCG2, ABCB6, ABCD1, ABCC3, ABCC2, ABCB8",1.63827216398241,0.696803942579511,TRUE
+"H2126","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.22995,-0.68,0.868,7987,1,"TCF7L2, MYC, CCND1, PIK3R3, PML",0.0614802748235081,0,FALSE
+"H2126","Input","KEGG_ADHERENS_JUNCTION",0.25036,0.726,0.83,1346,1,"NECTIN4, LMO7, PTPRM, CDH1, RAC2, WASL, CTNNA1, PTPRF, TGFBR1, IQGAP1, CTNNA2, RAC3",0.0809219076239261,0,FALSE
+"H2126","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.51611,1.51,0.0621,2311,0.305,"PRKAB2, PRKAB1, PRKAG1, ACSL1, PRKAA1, ADIPOR1, PRKAG2, ACSL3, IRS2, NFKBIB, PRKAA2, CPT1A, IKBKG, SLC2A1, IKBKB, TRAF2, ACSL5, ACACB, ACSL6, AKT1, RELA, MTOR, CHUK, RXRG, RXRA",1.20690839982342,0.515700160653214,FALSE
+"H2126","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32409,-0.993,0.394,8469,0.79,"GFPT2, GLS, GLS2, DDO",0.404503778174426,0.102372908709559,FALSE
+"H2126","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.20958,-0.634,0.928,7781,1,"PRKCB, IRS1, PIK3R3",0.0324520237811379,0,FALSE
+"H2126","Input","KEGG_ALZHEIMERS_DISEASE",0.25428,0.74,0.799,2827,1,"ATP2A3, ITPR1, CASP9, NDUFA2, BID, UQCRH, EIF2AK3, CACNA1F, CAPN2, CYC1, CDK5, PSEN2, UQCR10, IDE, SNCA, CHP1, NDUFB1, NDUFAB1, ATP2A2, NDUFA9, MAPK3, UQCRQ, NDUFC2, ATP5MC2, NDUFB7, CYCS, NDUFV2, NDUFS6, UQCRB, NDUFA5, NDUFB6, PSEN1, CASP7, FAS, NDUFA7, NDUFC1, CASP3, NDUFS4",0.0974532206860086,0,FALSE
+"H2126","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.21908,0.631,0.921,1725,1,"TARS2, NARS2, SEPSECS, VARS2, PARS2",0.0357403698031511,0,FALSE
+"H2126","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51946,1.52,0.0742,2147,0.308,"GNPNAT1, FPGT, GFPT1, GNPDA2, GALK2, NANS, PMM2, GNE, UGDH, PGM3, UXS1, GMDS, HK1, PGM2, PGM1, PMM1, MPI, GMPPA, GALE, CYB5R3, AMDHD2, NAGK, CYB5R1",1.12959609472097,0.511449283499556,FALSE
+"H2126","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.32373,-1,0.389,7922,0.791,"NEFH, PRPH, PRPH2, GRIN1, BCL2L1, MAP2K6, TOMM40L, CASP1, TP53, GPX1",0.410050398674292,0.101823516502323,FALSE
+"H2126","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.24207,-0.753,0.743,7492,1,"RFXANK, HSPA4, RFX5, CD74, TAP1, CTSS, CTSB",0.129011186239425,0,FALSE
+"H2126","Input","KEGG_APOPTOSIS",0.22094,0.621,0.925,2238,1,"CASP9, MYD88, BID, CAPN2, BIRC2, BAX, AIFM1, IKBKG, XIAP, CHP1, IKBKB, TRAF2, AKT1, IRAK4, RELA, ENDOG, CYCS, CHUK",0.0338582672609674,0,FALSE
+"H2126","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.5093,1.48,0.0724,812,0.325,"PTGES, PLA2G12A, PLA2G4A, GPX2, LTA4H",1.14026143380285,0.488116639021126,FALSE
+"H2126","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.33614,0.977,0.457,989,0.755,"AGMAT, GLUL, CKMT1A, PYCR1, CKMT2, GAMT, CPS1, GATM, OAT, ODC1, SRM, ALDH18A1",0.34008379993015,0.122053048370812,FALSE
+"H2126","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.53299,-1.63,0.0741,7855,0.593,"LAMA2, TCF7L2, ITGB8, CACNA2D2, ITGA2B, ITGA2, DSC2, ITGA6, ACTN1, LMNA, ITGA10, ITGB4, ACTG1, SGCB, CDH2, ITGB3, GJA1, CACNA2D1",1.13018179202067,0.226945306635737,FALSE
+"H2126","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.37229,-1.15,0.266,7617,0.667,"ALDH1B1, ALDH9A1",0.575118363368933,0.175874166083451,FALSE
+"H2126","Input","KEGG_AXON_GUIDANCE",-0.42414,-1.28,0.16,7255,0.685,"ROBO1, EFNA5, ABLIM1, SEMA4B, PAK3, SRGAP2, SRGAP3, EPHA7, DPYSL5, PLXNA1, ABLIM2, CXCR4, CFL2, GNAI1, EPHB3, PLXNA2, ABLIM3, PAK2, EPHB2, NFAT5, EPHA2, EPHA6, EPHA5, SEMA3A, DPYSL2, EFNB1, EPHA4, PLXNB3, NFATC2, EFNB2, SEMA5A",0.795880017344075,0.164309428507574,FALSE
+"H2126","Input","KEGG_BASAL_CELL_CARCINOMA",-0.6756,-2.1,0.00862,7503,0.778,"WNT5A, SUFU, FZD1, TCF7L2, GLI2, GLI3, FZD7, TP53",2.06449273417529,0.109020403010311,FALSE
+"H2126","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.54803,-1.66,0.0506,5616,0.691,"GTF2F1, GTF2E1, GTF2E2, GTF2IRD1, TAF5, TAF4, GTF2F2, TAF9, TAF6L, GTF2I, GTF2A1, TAF7, GTF2H2, TAF5L, GTF2H1, GTF2B, GTF2A2",1.2958494831602,0.160521952625802,FALSE
+"H2126","Input","KEGG_BASE_EXCISION_REPAIR",-0.16099,-0.491,0.997,6400,1,"POLD3, MBD4, POLL, POLE3, POLD2, LIG1, FEN1, POLD1, POLE, POLE2",0.00130484168834428,0,FALSE
+"H2126","Input","KEGG_BETA_ALANINE_METABOLISM",0.31702,0.907,0.554,900,0.809,"ACADM, SRM",0.25649023527157,0.0920514783877277,FALSE
+"H2126","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.35363,1.02,0.387,2304,0.694,"ACOX3, HACD1, ELOVL5, ACAA1, ACOT2, SCD, FADS2, ACOT1, TECR",0.412289034981089,0.158640529545145,FALSE
+"H2126","Input","KEGG_BLADDER_CANCER",-0.40679,-1.22,0.234,7877,0.651,"DAPK1, MMP1, MYC, CCND1, CDKN2A, TP53, THBS1",0.630784142589857,0.186419011431808,FALSE
+"H2126","Input","KEGG_BUTANOATE_METABOLISM",-0.52691,-1.62,0.0582,7606,0.502,"ALDH5A1, ALDH1B1, BDH1, ALDH9A1, BDH2, HMGCS2, ACSM3, OXCT1",1.23507701535011,0.299296282854981,FALSE
+"H2126","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.24858,-0.752,0.748,7781,1,"PRKCB, CARD11, BTK, LYN, NFAT5, JUN, PIK3R3, NFATC2, CD79A",0.126098402135539,0,FALSE
+"H2126","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2744,0.791,0.717,2265,0.985,"ATP2A3, ITPR1, CACNA1A, CD38, PHKA1, ATP2B1, SLC25A5, CACNA1F, VDAC2, LTB4R2, P2RX4, GNA11, PHKB, CHP1, ERBB3, ATP2A2, PHKG2, HRH1, SLC25A31, PHKA2, TACR1, SLC25A6, PPID, SPHK2",0.1444808443322,0.00656376950238827,FALSE
+"H2126","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.2875,-0.89,0.543,7402,0.919,"COX6B1, COX7C, TPM2, CACNA2D2, COX6A1, COX7A2, CACNA2D1",0.265200170411153,0.0366844886138887,FALSE
+"H2126","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.31486,0.907,0.56,449,0.809,"CLDN3, CDH5, CLDN7, PTPRM, CD40, ITGB2, CDH1",0.2518119729938,0.0920514783877277,FALSE
+"H2126","Input","KEGG_CELL_CYCLE",-0.29725,-0.913,0.514,6666,0.896,"SMC1A, PRKDC, WEE1, CDK4, CREBBP, SMAD4, E2F3, PLK1, RBL1, MCM2, RAD21, SMC1B, CCNA2, MAD2L1, SMC3, HDAC1, MCM7, MCM6, SMAD3, MCM3, CDKN2D, ORC6, MAD1L1, CDC25C, MCM4, MYC, ATR, PTTG1, CCND1, TGFB2, CDKN2A, TP53, CDK6, CDKN2C",0.289036881004724,0.0476919903378748,FALSE
+"H2126","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.17888,-0.557,0.979,7139,1,"PLCB2, PLCB3, PREX1, VAV1, ELMO1, GRK6, CXCR4, PRKCB, GNB4, GNAI1, CXCL5, LYN, ADCY3, ADCY8, WAS, GNG7, CCL5, PIK3R3, GNG4",0.00921730819686218,0,FALSE
+"H2126","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.37521,-1.18,0.233,6791,0.629,"CDK4, NFKB1, SMAD4, E2F3, CTBP2, RUNX1, HDAC1, BAD, SMAD3, TGFBR2, BCL2L1, MYC, CCND1, TGFB2, MECOM, CDKN2A, GAB2, TP53, CDK6, PIK3R3",0.632644078973981,0.201349354554731,FALSE
+"H2126","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.67963,1.99,0.00444,862,0.155,"BHLHE41, PER2, CSNK1E",2.35261702988538,0.809668301829709,TRUE
+"H2126","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.26045,0.743,0.772,2193,1,"ACLY, IDH2, DLAT, MDH2, IDH1, SUCLG2, DLST, DLD",0.112382699664264,0,FALSE
+"H2126","Input","KEGG_COLORECTAL_CANCER",-0.26635,-0.803,0.668,7455,1,"BAD, APPL1, SMAD3, TCF7L2, TGFBR2, MYC, CCND1, TGFB2, JUN, TP53, PIK3R3",0.175223537524454,0,FALSE
+"H2126","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.47122,1.37,0.131,256,0.381,"FGA, FGG, TFPI, FGB, MASP1, PLAUR",0.882728704344236,0.419075024324381,FALSE
+"H2126","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.28799,0.815,0.7,2023,0.949,"CTH, ENOPH1, LDHA, SRM, ADI1, GOT1, AHCYL1, TAT",0.154901959985743,0.0227337875727074,FALSE
+"H2126","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.38952,-1.23,0.181,7335,0.655,"IL1RAP, BMPR2, TNFRSF10A, CXCR4, PLEKHO2, TNFRSF21, ACVR2A, CXCL5, CD70, TGFBR2, IFNAR1, TNFRSF10D, IL6ST, TGFB2, TNFRSF10B, CCL5, INHBA, NGFR",0.742321425130815,0.183758700008217,FALSE
+"H2126","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.2747,-0.843,0.578,8380,0.951,"ZBP1, TREX1, CASP1, CCL5",0.238072161579471,0.0218194830625861,FALSE
+"H2126","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.47591,-1.48,0.0914,7835,0.57,"TPM2, LAMA2, ITGB8, CACNA2D2, ADCY3, ADCY8, ITGA2B, ITGA2, TGFB2, ITGA6, LMNA, ITGA10, ITGB4, ACTG1, SGCB, ITGB3, CACNA2D1",1.03905380426617,0.244125144327509,FALSE
+"H2126","Input","KEGG_DNA_REPLICATION",-0.41424,-1.28,0.184,6307,0.685,"POLA2, POLD3, RPA3, POLE3, POLD2, POLA1, MCM2, LIG1, FEN1, PRIM2, MCM7, POLD1, MCM6, POLE, MCM3, POLE2, MCM4",0.735182176990464,0.164309428507574,FALSE
+"H2126","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.23097,-0.714,0.801,7978,1,"NOTCH2, NOTCH1",0.0963674839157623,0,FALSE
+"H2126","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.46523,1.36,0.112,487,0.382,"ALDH3B1, GSTM3, GSTK1, MGST2, MGST1, ALDH1A3, GSTZ1",0.950781977329818,0.417936637088291,FALSE
+"H2126","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.31743,0.924,0.529,929,0.815,"CDA, CES1, CES2, TYMP, TPMT",0.276544327964814,0.0888423912600234,FALSE
+"H2126","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.55437,-1.68,0.0542,7522,0.902,"ITGA3, COL5A1, COL5A2, LAMB3, SPP1, COL1A1, LAMC2, LAMA2, COL4A2, CD47, COL6A1, LAMB2, LAMC1, ITGB8, HMMR, COL1A2, ITGA2B, FN1, ITGA2, ITGA6, ITGA10, ITGB4, THBS1, ITGB3, THBS2, COL6A2, COL4A1",1.26600071346161,0.0447934624580583,FALSE
+"H2126","Input","KEGG_ENDOCYTOSIS",0.30537,0.899,0.575,2973,0.813,"ARRB1, CHMP2A, ARFGAP1, ARFGAP3, USP8, DAB2, CHMP2B, HSPA2, PIKFYVE, RAB31, ARRB2, PSD, RAB11FIP4, SMURF1, ACAP1, VPS37C, CHMP5, RAB11A, ASAP2, STAM2, CHMP4A, CHMP4B, CHMP1B, PIP5K1C, VPS25, PLD2, ERBB3, VPS45, EHD1, AP2A1, SNF8, RAB22A, NEDD4, PLD1, CHMP4C, CLTC, RAB11B, HSPA1L, SH3GL1, CDC42, ITCH, AP2M1, SMAP1, HSPA6, CHMP3, HSPA1A, RAB5B, DNAJC6, VPS37A, CBL, STAMBP, EGFR, VPS36",0.24033215531037,0.0899094544059319,FALSE
+"H2126","Input","KEGG_ENDOMETRIAL_CANCER",-0.20567,-0.625,0.944,7987,1,"TCF7L2, MYC, CCND1, TP53, PIK3R3",0.025028005701931,0,FALSE
+"H2126","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.22622,-0.708,0.856,8136,1,"LYN, ATP6V1B2, JUN, CCL5, HBEGF, PTPRZ1",0.0675262353228468,0,FALSE
+"H2126","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.25997,-0.813,0.678,6992,0.993,"NCK1, PAK1, CAMK2D, PAK3, PLCG2, BAD, PRKCB, CAMK2B, MYC, PAK2, JUN, HBEGF, NRG1, PIK3R3, CAMK2G",0.168770306132937,0.00305075150461883,FALSE
+"H2126","Input","KEGG_ETHER_LIPID_METABOLISM",0.50907,1.46,0.0739,2183,0.321,"PLA2G12A, PLA2G4A, PAFAH2, PLPP3, PLD2, PLD1, PAFAH1B3, PLA2G7",1.13135556160517,0.493494967595128,FALSE
+"H2126","Input","KEGG_FATTY_ACID_METABOLISM",-0.27864,-0.853,0.605,7617,0.943,"ALDH1B1, ADH4, ADH7, ACADSB, ADH1C, ALDH9A1, ACAA2, GCDH, ECI1, ACSL4",0.218244625347531,0.0254883072626717,FALSE
+"H2126","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.2122,0.605,0.937,2447,1,"PLA2G12A, PLA2G4A, RAC2, PRKCD, VAV2, RAC3, MAPK13, RAC1, AKT1, MAPK3, GRB2, PDPK1, MAPK12, SOS1",0.0282604091122217,0,FALSE
+"H2126","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.22441,-0.68,0.841,8136,1,"LYN, ARPC1A, PTPRC, SCIN, WAS, ASAP3, PLPP1, GAB2, WASF1, PIK3R3",0.0752040042020878,0,FALSE
+"H2126","Input","KEGG_FOCAL_ADHESION",-0.35199,-1.09,0.33,7522,0.732,"ITGA3, COL5A1, COL5A2, LAMB3, SPP1, COL1A1, PRKCB, LAMC2, LAMA2, COL4A2, COL6A1, LAMB2, LAMC1, ITGB8, COL1A2, PAK2, ITGA2B, CCND1, FLNA, FN1, ITGA2, ITGA6, JUN, ACTN1, CAV1, FLNC, ITGA10, ITGB4, THBS1, PIK3R3, ACTG1, MYLK, ITGB3, THBS2, COL6A2, COL4A1",0.481486060122112,0.135488918941608,FALSE
+"H2126","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.51847,-1.67,0.0448,8658,0.779,"ALPI, ALPP, ALPG",1.34872198600186,0.108462542327436,FALSE
+"H2126","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5654,1.68,0.0329,1756,0.205,"FBP1, ALDOB, PHPT1, FPGT, FBP2, PFKFB4, PMM2, GMDS, HK1, AKR1B1, PMM1, MPI, GMPPA, SORD",1.48280410205003,0.688246138944246,TRUE
+"H2126","Input","KEGG_GALACTOSE_METABOLISM",0.33023,0.975,0.469,2577,0.731,"GALK2, B4GALT1, HK1, PGM2, AKR1B1, PGM1, GALE, PFKP, HK2, GALK1",0.328827157284917,0.13608262304214,FALSE
+"H2126","Input","KEGG_GAP_JUNCTION",-0.22428,-0.675,0.874,7005,1,"GNAS, PLCB2, PLCB3, CSNK1D, TUBA4A, PRKCB, GNAI1, ITPR3, TUBB4A, ADCY3, ADCY8, GJA1",0.058488567365597,0,FALSE
+"H2126","Input","KEGG_GLIOMA",-0.38925,-1.18,0.244,8123,0.629,"CAMK2B, CCND1, CDKN2A, TP53, CDK6, PIK3R3, CAMK2G",0.612610173661271,0.201349354554731,FALSE
+"H2126","Input","KEGG_GLUTATHIONE_METABOLISM",0.50785,1.46,0.0988,1457,0.321,"GSTM3, GSTK1, MGST2, MGST1, G6PD, TXNDC12, GPX2, GSTZ1, RRM2, IDH2, ODC1, SRM, MGST3, IDH1, RRM1",1.00524305541237,0.493494967595128,FALSE
+"H2126","Input","KEGG_GLYCEROLIPID_METABOLISM",0.28383,0.82,0.672,1849,0.954,"GK2, AKR1A1, DGAT1, AKR1B1, PLPP3, DGKE, AGK, GPAT4, MGLL",0.172630726946175,0.0204516252959049,FALSE
+"H2126","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40749,1.17,0.255,2154,0.556,"LPGAT1, PLA2G12A, PEMT, PLA2G4A, CDS1, MBOAT7, PTDSS2, PISD, PLPP3, DGKE, LYPLA2, PLD2, GPAT4, LPCAT3, PLD1, PTDSS1, GPAM",0.593459819566045,0.254925208417942,FALSE
+"H2126","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.37929,1.09,0.327,675,0.622,"CTH, GAMT, GATM, GLDC, GCAT",0.485452247339714,0.206209615309181,FALSE
+"H2126","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.36834,1.07,0.346,1343,0.62,"FBP1, ALDOB, ALDH3B1, ALDH1A3, FBP2, GALM, AKR1A1, ACSS2, LDHA, DLAT, HK1, PGK1, BPGM, PGM2, PGM1",0.460923901207223,0.207608310501746,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.34847,1.01,0.431,1989,0.701,"B3GAT3, CHPF2, CHST12, B4GALT7",0.365522729839268,0.154281982033341,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.3983,1.15,0.254,1989,0.537,"HS6ST2, B3GAT3, EXT1, B4GALT7",0.595166283380062,0.270025714300444,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.70892,2.06,0.00612,652,0.127,"ST3GAL2, ST3GAL1, B4GALT4, B4GALT1",2.21324857785444,0.896196279044043,TRUE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.69667,-2.07,0.0129,8038,0.311,"GLB1, ARSB, HEXB, HEXA, SGSH, HPSE",1.88941028970075,0.507239610973163,FALSE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.5861,1.69,0.0329,101,0.209,"ST3GAL2, ST3GAL1",1.48280410205003,0.679853713888946,TRUE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.59275,1.73,0.0267,101,0.189,"ST3GAL2, ST3GAL1",1.57348873863542,0.723538195826756,TRUE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.7532,2.14,0.00796,652,0.105,"B3GNT3, ST3GAL4, B4GALT4, B4GALT1",2.09908693226233,0.978810700930062,TRUE
+"H2126","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.81012,2.31,0,1328,0.0724,"PIGO, PIGU, PIGA, PIGK, PIGT, GPAA1, PIGS",Inf,1.14026143380285,TRUE
+"H2126","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.29087,0.842,0.644,1256,0.921,"MDH2, PGP",0.191114132640188,0.0357403698031511,FALSE
+"H2126","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.25041,0.735,0.812,266,1,"ITPR1, ADCY5, PLA2G12A, PLA2G4A",0.0904439707588247,0,FALSE
+"H2126","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.52487,-1.61,0.0523,7343,0.474,"CSNK1D, WNT5A, SUFU, RAB23, GLI2, GLI3",1.28149831113273,0.324221658325915,FALSE
+"H2126","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.50948,-1.58,0.0653,8329,0.479,"ITGA2B, ITGA2, ITGA6, CD33, ITGB3, CD7",1.18508681872493,0.319664486585437,FALSE
+"H2126","Input","KEGG_HISTIDINE_METABOLISM",0.45345,1.33,0.137,478,0.408,"ALDH3B1, BUD23, ALDH1A3, METTL2B",0.863279432843593,0.38933983691012,FALSE
+"H2126","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.22331,0.651,0.91,1620,1,"MUS81, SSBP1, RAD51, BLM",0.0409586076789064,0,FALSE
+"H2126","Input","KEGG_HUNTINGTONS_DISEASE",-0.14886,-0.463,1,7136,0.998,"NDUFB9, PLCB2, PLCB3, POLR2L, BBC3, COX6B1, POLR2E, HDAC1, POLR2G, ATP5F1B, ATP5F1E, COX7C, ATP5PD, POLR2F, ATP5F1A, DLG4, ATP5PO, GRIN1, COX6A1, TP53, NDUFA4, COX7A2, GPX1, HIP1",0,0.000869458712628891,FALSE
+"H2126","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.40467,-1.25,0.171,7835,0.692,"TPM2, LAMA2, ITGB8, CACNA2D2, ITGA2B, ITGA2, TGFB2, ITGA6, LMNA, ITGA10, ITGB4, ACTG1, SGCB, ITGB3, ACE, CACNA2D1",0.767003889607846,0.159893905543242,FALSE
+"H2126","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.21722,0.639,0.927,1643,1,"OCRL, INPP4B, PIKFYVE, PIP4K2C, PI4KB, PIP5K1C, ITPK1, IMPA2, ALDH6A1",0.0329202658555029,0,FALSE
+"H2126","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.37326,1.08,0.332,2333,0.614,"FBP1, PRKAB2, MKNK1, FBP2, PRKAB1, PRKAG1, PHKA1, PRKAA1, GYS1, PRKAG2, PYGL, RHEB, IRS2, PTPRF, HK1, PRKAA2, PYGM, RPS6KB2, SREBF1, PPP1R3D, PHKB, IKBKB, ACACB, AKT1, PHKG2, MTOR, MAPK3, PHKA2, GRB2, SHC1, ACACA, ARAF, HK2, PDPK1",0.478861916295964,0.211831628858832,FALSE
+"H2126","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.42663,1.23,0.186,978,0.493,"CD40, LTBR",0.730487055782084,0.30715308072277,FALSE
+"H2126","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.42385,-1.3,0.192,8043,0.708,"IRF9, IFNAR1, BCL2L1, MYC, IL6ST, CCND1, PIAS2, SPRED1, SPRY4, PIK3R3, SPRY1",0.71669877129645,0.149966742310231,FALSE
+"H2126","Input","KEGG_LEISHMANIA_INFECTION",-0.23821,-0.698,0.791,8390,1,"TGFB2, JUN, C3, CYBA",0.101823516502323,0,FALSE
+"H2126","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.22884,0.671,0.896,1784,1,"CLDN3, CDH5, CLDN7, ITGB2, RAC2, CTNNA1, PXN, VAV2, VASP, CTNNA2, ROCK1, OCLN, F11R, CTNND1, MAPK13, RAC1",0.0476919903378748,0,FALSE
+"H2126","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.52114,-1.62,0.0739,7617,0.502,"ALDH1B1, ALDH9A1",1.13135556160517,0.299296282854981,FALSE
+"H2126","Input","KEGG_LONG_TERM_DEPRESSION",0.40839,1.18,0.242,266,0.553,"ITPR1, PLA2G12A, CACNA1A, PLA2G4A",0.616184634019569,0.257274868695302,FALSE
+"H2126","Input","KEGG_LONG_TERM_POTENTIATION",-0.24765,-0.748,0.754,7139,1,"PLCB2, PLCB3, CAMK2D, PRKCB, ITPR3, GRIN1, CAMK2B, ADCY8, CAMK2G",0.122628654130226,0,FALSE
+"H2126","Input","KEGG_LYSINE_DEGRADATION",-0.39531,-1.21,0.207,6028,0.65,"PLOD3, NSD1, NSD2, TMLHE, ACAT1, SETD1A, EHMT2, SUV39H1, SETDB2, SETDB1, NSD3, SETD2, ALDH1B1, ALDH9A1, GCDH, SETMAR, AASS, PLOD2",0.684029654543082,0.187086643357144,FALSE
+"H2126","Input","KEGG_LYSOSOME",-0.28115,-0.883,0.578,7818,0.919,"AP3S1, CTSZ, MFSD8, IGF2R, GLB1, CTSV, PLA2G15, NPC2, CTSF, ARSB, SMPD1, SUMF1, PPT2, AP1S2, MANBA, HEXB, HEXA, CTSS, CTSB, SGSH, CTSK, CTSO",0.238072161579471,0.0366844886138887,FALSE
+"H2126","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.23147,-0.72,0.799,7646,1,"DAXX, RPS6KA4, MAPKAPK3, PRKCB, SRF, RRAS2, TGFBR2, CACNA2D2, MYC, FGF13, FGF2, NTRK2, PAK2, MAP2K6, JUND, FLNA, TGFB2, FGFR2, DUSP16, JUN, MECOM, FLNC, TP53, NFATC2, CACNA2D1",0.0974532206860086,0,FALSE
+"H2126","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.402,1.16,0.238,1039,0.56,"IAPP, PDX1",0.623423042943488,0.2518119729938,FALSE
+"H2126","Input","KEGG_MELANOGENESIS",-0.40343,-1.27,0.163,6863,0.679,"ASIP, CREBBP, GNAS, DCT, PLCB2, PLCB3, CAMK2D, WNT5A, PRKCB, FZD1, GNAI1, TCF7L2, MITF, CAMK2B, ADCY3, ADCY8, FZD7, CAMK2G",0.787812395596042,0.168130225719498,FALSE
+"H2126","Input","KEGG_MELANOMA",-0.43512,-1.35,0.161,8000,0.672,"MITF, FGF13, FGF2, CCND1, CDKN2A, TP53, CDK6, PIK3R3",0.79317412396815,0.172630726946175,FALSE
+"H2126","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.49098,1.44,0.0861,487,0.331,"ALDH3B1, GSTM3, GSTK1, MGST2, CYP1B1, MGST1, ALDH1A3, GSTZ1",1.06499684854635,0.480172006224281,FALSE
+"H2126","Input","KEGG_MISMATCH_REPAIR",0.15748,0.454,1,7463,1,"SSBP1, RFC1, MSH3, PCNA, POLD4, MLH3, RFC5, MSH6, RFC3, MSH2, RFC2, RPA1, RPA2, PMS2, RFC4, MLH1, POLD3, RPA3, POLD2, LIG1, POLD1",0,0,FALSE
+"H2126","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.41873,1.23,0.188,2504,0.493,"CAB39L, PRKAA1, CAB39, RHEB, PRKAA2, RPS6KB2, EIF4B, AKT1, MTOR, MAPK3, RICTOR, PDPK1, MLST8",0.72584215073632,0.30715308072277,FALSE
+"H2126","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.29637,-0.918,0.509,7327,0.918,"VAV1, PLCG2, TNFRSF10A, PRKCB, IFNAR1, TNFRSF10D, ULBP1, NFAT5, TNFRSF10B, PIK3R3, RAET1L, ULBP2, NFATC2",0.293282217663241,0.0371573187987575,FALSE
+"H2126","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.40933,1.19,0.222,2607,0.549,"PRSS3, LTB4R2, P2RX4, HRH1, TSPO, P2RY11, TACR1, HCRTR1, MAS1",0.653647025549361,0.260427655549908,FALSE
+"H2126","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.16712,-0.51,0.994,7214,1,"TRAF6, CAMK2D, PLCG2, BAD, KIDINS220, RPS6KA4, IRS1, CAMK2B, NTRK2, JUN, TP53, PIK3R3, NGFR, CAMK2G",0.00261361560268669,0,FALSE
+"H2126","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.40558,-1.23,0.223,8093,0.655,"PNP, NNT, NT5E, BST1, NMNAT3, NUDT12",0.651695136951839,0.183758700008217,FALSE
+"H2126","Input","KEGG_NITROGEN_METABOLISM",-0.48123,-1.43,0.122,8739,0.589,"CA2, GLS, GLS2, CA12",0.913640169325252,0.229884705212898,FALSE
+"H2126","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.20752,0.594,0.968,2371,0.993,"CCL13, TAB3, NFKBIB, BIRC2, IKBKG, XIAP, IKBKB, MAPK13, RELA, MAPK3, CHUK, MAPK12, SUGT1",0.0141246426916063,0.00305075150461883,FALSE
+"H2126","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.38277,-1.18,0.218,6694,0.629,"POLL, PRKDC, FEN1, NHEJ1",0.661543506395395,0.201349354554731,FALSE
+"H2126","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.26276,-0.796,0.643,8344,1,"CCND1, CDKN2A, TP53, CDK6, PIK3R3",0.191789027075778,0,FALSE
+"H2126","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.47003,-1.46,0.0864,6681,0.57,"SNW1, NCOR2, NUMBL, RBPJ, CREBBP, JAG1, JAG2, CTBP2, DLL3, MAML1, HDAC1, NOTCH2, DTX3L, MAML2, NOTCH1",1.06348625752111,0.244125144327509,FALSE
+"H2126","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.19128,-0.583,0.968,6021,1,"RFC4, ERCC2, ERCC6, POLD3, RPA3, POLE3, POLD2, XPC, GTF2H2, LIG1, POLD1, GTF2H1, POLE, POLE2",0.0141246426916063,0,FALSE
+"H2126","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.60494,1.78,0.0222,2635,0.212,"MGAT4A, ST6GAL1, ALG5, ALG8, DPAGT1, ALG9, DPM3, ALG13, ALG3, ALG6, B4GALT1, DOLPP1, DPM1, MAN1B1, MOGS, MAN1A1, STT3B, RPN2, ALG1, MAN2A1, ALG2, ALG14, STT3A, B4GALT3, MGAT1, RFT1, DAD1, DDOST, MAN2A2, ALG11",1.65364702554936,0.673664139071249,TRUE
+"H2126","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.46831,-1.42,0.114,6939,0.574,"CNGB1, CAMK2D, CAMK2B, ADCY3, CAMK2G",0.943095148663527,0.241088107602027,FALSE
+"H2126","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.34213,-1.07,0.326,6014,0.723,"MTHFD1, MTHFS, GART, SHMT2, MTHFD1L, ALDH1L1",0.486782399932061,0.140861702705469,FALSE
+"H2126","Input","KEGG_OOCYTE_MEIOSIS",0.15329,0.439,1,123,0.999,"ITPR1, ADCY5",0,0.000434511774017692,FALSE
+"H2126","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.5262,-1.63,0.0565,6833,0.593,"MAN2B2, GBA, FUCA2, MAN2B1, GLB1, MANBA, HEXB, HEXA",1.24795155218056,0.226945306635737,FALSE
+"H2126","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.1508,-0.466,0.997,7354,1,"ATP6V1H, COX6B1, ATP6V1A, ATP5MG, ATP5F1B, ATP5F1E, COX7C, ATP5PD, ATP5ME, ATP5F1A, ATP5PO, COX6A1, ATP6V1B2, NDUFA4, COX7A2",0.00130484168834428,0,FALSE
+"H2126","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.67285,1.94,0.0135,106,0.171,"GCNT3, GALNT6, ST3GAL2, ST3GAL1, GALNT3",1.86966623150499,0.767003889607846,TRUE
+"H2126","Input","KEGG_P53_SIGNALING_PATHWAY",-0.33435,-1.04,0.35,8005,0.752,"COP1, ATR, CCND1, TNFRSF10B, CDKN2A, TP53, CDK6, THBS1, STEAP3, SERPINE1",0.455931955649724,0.123782159408358,FALSE
+"H2126","Input","KEGG_PANCREATIC_CANCER",-0.22021,-0.677,0.855,8046,1,"TGFBR2, BCL2L1, CCND1, TGFB2, CDKN2A, TP53, CDK6, PIK3R3",0.0680338852718274,0,FALSE
+"H2126","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.45499,1.3,0.16,536,0.424,"ENPP1, PPCDC, PPCS",0.795880017344075,0.372634143407267,FALSE
+"H2126","Input","KEGG_PARKINSONS_DISEASE",0.24269,0.693,0.859,2827,1,"CASP9, NDUFA2, UQCRH, SLC25A5, CYC1, VDAC2, UBA7, UBE2L3, UQCR10, SNCA, UBE2J1, NDUFB1, NDUFAB1, SLC18A1, NDUFA9, UQCRQ, SLC25A31, NDUFC2, ATP5MC2, NDUFB7, SLC25A6, CYCS, PPID, UBE2G2, PARK7, NDUFV2, NDUFS6, UCHL1, UBE2G1, UQCRB, NDUFA5, NDUFB6, NDUFA7, NDUFC1, CASP3, NDUFS4",0.0660068361687577,0,FALSE
+"H2126","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.23423,-0.727,0.777,8023,1,"TUBB4A, ARHGEF2, ARPC1A, HCLS1, WAS, ACTG1",0.109578981199086,0,FALSE
+"H2126","Input","KEGG_PATHWAYS_IN_CANCER",-0.29321,-0.914,0.498,7429,0.91,"HDAC1, PLCG2, BAD, APPL1, WNT5A, ITGA3, SUFU, SMAD3, LAMB3, PRKCB, LAMC2, FZD1, LAMA2, DAPK1, COL4A2, TPR, TCF7L2, LAMB2, MITF, LAMC1, TGFBR2, MMP1, FOXO1, BCL2L1, MYC, FGF13, FGF2, ITGA2B, CCND1, FN1, ITGA2, FH, TGFB2, FGFR2, ITGA6, JUN, GLI2, GLI3, PIAS2, FZD7, MECOM, CDKN2A, GSTP1, TP53, CDK6, PIK3R3, PML, COL4A1",0.302770657240282,0.0409586076789064,FALSE
+"H2126","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.46733,1.38,0.115,1831,0.382,"UGDH, AKR1B1, DCXR",0.939302159646388,0.417936637088291,FALSE
+"H2126","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.62853,1.79,0.0216,1343,0.227,"FBP1, ALDOB, G6PD, FBP2, PRPS1, PRPS1L1, PRPS2, PGM2, RBKS, PGM1",1.66554624884907,0.643974142806877,TRUE
+"H2126","Input","KEGG_PEROXISOME",0.47747,1.39,0.129,1757,0.382,"GSTK1, ACOX3, ABCD1, PXMP4, SCP2, PRDX1, ACSL1, ACAA1, ACSL3, IDH2, ECH1, SLC27A2, PEX1, SLC25A17, MPV17, PEX26, PMVK, PEX13, MVK, CAT, CRAT, IDH1, PEX16, AMACR, ACSL5, ACSL6, XDH",0.889410289700751,0.417936637088291,FALSE
+"H2126","Input","KEGG_PHENYLALANINE_METABOLISM",0.39329,1.15,0.252,1031,0.537,"ALDH3B1, ALDH1A3, MIF",0.598599459218456,0.270025714300444,FALSE
+"H2126","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25005,0.729,0.82,1584,1,"ITPR1, OCRL, CDS1, INPP4B, PIKFYVE, PIP4K2C, PI4KB, PIP5K1C, DGKE, ITPK1, IMPA2",0.0861861476162833,0,FALSE
+"H2126","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.27965,-0.861,0.584,7910,0.94,"ALAS1, FECH, FTH1",0.233587152887601,0.0268721464003014,FALSE
+"H2126","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.44366,1.29,0.15,872,0.425,"FABP6, FABP3, ACADM, ACOX3, OLR1, SCP2, GK2, ACSL1, ACAA1, ACSL3, SLC27A2, FABP5",0.823908740944319,0.371611069949688,FALSE
+"H2126","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.37483,-1.13,0.273,7144,0.688,"RFXAP, RFXANK, RFX5, BTK, TAP1, PTPRC, CD79A",0.563837352959244,0.162411561764489,FALSE
+"H2126","Input","KEGG_PRION_DISEASES",-0.32574,-1.01,0.401,8022,0.785,"LAMC1, NOTCH1, CCL5",0.396855627379818,0.105130343254747,FALSE
+"H2126","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.19384,0.563,0.971,2436,0.998,"ADCY5, FZR1, PKMYT1, ANAPC11, CDC25B, CDC26, MAPK13, AKT1, MAPK3, CDC23, ANAPC4, GNAI3, ARAF, MAPK12, CDC16, ANAPC5",0.0127807700919951,0.000869458712628891,FALSE
+"H2126","Input","KEGG_PROPANOATE_METABOLISM",-0.23567,-0.707,0.79,8092,1,"LDHB, ALDH9A1, ACSS3, ACSS1",0.102372908709559,0,FALSE
+"H2126","Input","KEGG_PROSTATE_CANCER",-0.24166,-0.753,0.746,7987,1,"TCF7L2, FOXO1, CCND1, FGFR2, GSTP1, TP53, PIK3R3",0.127261172527331,0,FALSE
+"H2126","Input","KEGG_PROTEASOME",-0.17793,-0.55,0.984,2238,1,"PSMA5, PSMF1, PSMB7, POMP, PSMB6, PSMB2, PSMD12, PSMA1, PSMD2, PSMC6, PSMA6, PSMA3, PSMB1, PSMA7, PSMC3, PSMB5, PSMA2, PSMA8, PSMB10, PSMB4, PSMC4, PSMD3, PSMC1, PSME2, PSMD13, PSMD11, PSME1, PSMA4, PSMD4, PSMC2, PSMC5, PSMD6, PSMD1, PSME3, PSMD8, PSMD7, PSMB8, SEM1, PSMD14, PSMB3, PSMB9",0.00700490156865849,0,FALSE
+"H2126","Input","KEGG_PROTEIN_EXPORT",0.66921,1.91,0.0174,2359,0.17,"SRPRB, SRPRA, SEC62, SRP19, SRP54, SEC11C, SRP68, SRP72, SPCS2, SEC61B, SEC61A1, SPCS3, OXA1L",1.7594507517174,0.769551078621726,TRUE
+"H2126","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.66755,-2.07,0.0157,8416,0.311,"PCK2, CA2, GLS, GLS2",1.80410034759077,0.507239610973163,FALSE
+"H2126","Input","KEGG_PURINE_METABOLISM",0.33619,0.975,0.456,1077,0.731,"PDE4D, ADCY5, PAPSS2, CANT1, FHIT, ENPP1, NME3, RRM2, PRPS1, PRPS1L1, NT5C2, PDE5A, NME1, ADA, NUDT5, GDA, PRPS2, AK1",0.341035157335565,0.13608262304214,FALSE
+"H2126","Input","KEGG_PYRIMIDINE_METABOLISM",0.22053,0.634,0.923,1150,1,"CANT1, CMPK1, CDA, NME3, RRM2, TYMP, TXNRD2, NT5C2, NME1, TXNRD1, CTPS1",0.0347982989740879,0,FALSE
+"H2126","Input","KEGG_PYRUVATE_METABOLISM",-0.29274,-0.902,0.532,8021,0.906,"PKM, LDHB, ME3, ALDH9A1, PCK2, ACSS1",0.274088367704952,0.0428718023231869,FALSE
+"H2126","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.23371,-0.738,0.796,7257,1,"IQGAP2, ABI2, VAV1, ARHGEF7, PAK3, MOS, MSN, ITGA3, CFL2, ENAH, FGD1, RRAS2, ITGB8, FGF13, FGF2, ARPC1A, PAK2, ITGA2B, SCIN, FN1, ITGA2, WAS, FGFR2, ITGA6, ACTN1, ITGA10, ITGB4, WASF1, PIK3R3, ACTG1, MYLK, ITGB3",0.0990869322623309,0,FALSE
+"H2126","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.39457,1.15,0.266,1098,0.537,"PRKAA1, PRKAA2, ATG4C",0.575118363368933,0.270025714300444,FALSE
+"H2126","Input","KEGG_RENAL_CELL_CARCINOMA",-0.26041,-0.814,0.688,8261,1,"PAK2, FH, TGFB2, JUN, FLCN, PIK3R3",0.162411561764489,0,FALSE
+"H2126","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.61812,-1.93,0.0202,7585,0.433,"LNPEP, ANPEP, ACE",1.69464863055338,0.363512103646635,FALSE
+"H2126","Input","KEGG_RETINOL_METABOLISM",-0.40012,-1.24,0.194,7759,0.685,"ADH4, ADH7, ADH1C, DHRS9, ALDH1A2, CYP3A7",0.712198270069774,0.164309428507574,FALSE
+"H2126","Input","KEGG_RIBOFLAVIN_METABOLISM",0.57825,1.67,0.044,876,0.2,"PHPT1, ENPP1, RFK, ACP6",1.35654732351381,0.698970004336019,TRUE
+"H2126","Input","KEGG_RIBOSOME",0.37424,1.08,0.317,3841,0.614,"RPL37, RPL35, RPL7A, RPL14, RPL18, RPS29, RPL38, RPL29, RPL18A, RPL22, RPL13A, RPS9, RPL36, RPL34, RPL7, RPL10A, RPS5, RPS16, RPL26, RPL23A, RPLP2, RPL30, RPS11, RPL37A, RPS15, RPS18, RPS3, RPL10, RPL15, RPS27A, RPL3, RPL28, RPL6, RPL17, RPL27, RPL35A, RPS13, RPS2, RPS12, UBA52, RPL9, RPS27L, RPS3A, RPS10, RPL19, RPS4X, RPS15A, RPS24, RPS8, RPS17, FAU, RPS25",0.498940737782249,0.211831628858832,FALSE
+"H2126","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.16254,-0.501,0.989,7873,1,"DDX58, AZI2, CYLD, ISG15",0.0048037084028206,0,FALSE
+"H2126","Input","KEGG_RNA_DEGRADATION",-0.30221,-0.924,0.523,5684,0.94,"TENT4A, PARN, C1D, LSM3, LSM7, EXOSC1, EXOSC7, EXOSC5, EXOSC8, EXOSC4, EXOSC3, HSPD1, PNPT1, LSM8, DCPS, LSM2, EXOSC2, DCP2, LSM6, MPHOSPH6, ENO2, DCP1B",0.281498311132726,0.0268721464003014,FALSE
+"H2126","Input","KEGG_RNA_POLYMERASE",-0.24479,-0.753,0.763,2161,1,"POLR3K, POLR3B, POLR3C, POLR3F, POLR2I, POLR3GL, POLR3A, POLR3H, POLR3D, POLR2C, POLR2B, POLR1C, POLR1D, POLR1A, POLR1B, POLR2H, POLR2J, POLR3G, POLR1E, POLR2K, POLR2D, POLR2A, POLR2L, POLR2E, POLR2G, POLR2F",0.11747546204512,0,FALSE
+"H2126","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.4481,1.3,0.153,478,0.424,"PAPSS2, BUD23, CTH, METTL2B",0.815308569182401,0.372634143407267,FALSE
+"H2126","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.3302,-1.01,0.375,7663,0.785,"LAMB3, LAMC2, LAMA2, COL4A2, LAMB2, LAMC1, BCL2L1, MYC, ITGA2B, CCND1, FN1, ITGA2, ITGA6, PIAS2, TP53, CDK6, PIK3R3, COL4A1",0.425968732272281,0.105130343254747,FALSE
+"H2126","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.36545,1.06,0.352,2249,0.626,"STX16, SEC22B, YKT6, VAMP7, BNIP1, BET1L, STX18, SNAP47, VAMP3, VTI1B, SNAP23, GOSR1, SNAP29",0.453457336521869,0.20342566678957,FALSE
+"H2126","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.3853,-1.18,0.228,8038,0.629,"GLB1, KDSR, SMPD1, PLPP1, UGT8",0.642065152999546,0.201349354554731,FALSE
+"H2126","Input","KEGG_SPLICEOSOME",-0.36522,-1.12,0.292,5534,0.688,"RBM8A, SF3B5, SNRPD1, SNRPD2, HNRNPU, ACIN1, SNRPG, PQBP1, SRSF5, SRSF6, PRPF18, LSM3, LSM7, SRSF10, WBP11, PPIL1, RBMX, HNRNPC, SNRPC, SF3B6, SRSF1, MAGOHB, ALYREF, SRSF7, TCERG1, SNRNP27, PRPF31, RBM25, SF3B3, ISY1, SF3A3, U2AF2, SRSF3, ZMAT2, CTNNBL1, SNRPB, DDX39B, SRSF2, EFTUD2, SNRPF, BUD31, SRSF8, CWC15, LSM8, SNW1, PLRG1, PRPF38A, DDX42, LSM2, SMNDC1, HNRNPA1, SYF2, TRA2B, SNU13, BCAS2, RBM17, EIF4A3, PRPF40A, RBM22, SLU7, SNRNP40, CDC5L, SRSF4, HNRNPA3, U2SURP, CDC40, HNRNPM, LSM6, PRPF19, TRA2A, HNRNPK, TXNL4A",0.534617148551582,0.162411561764489,FALSE
+"H2126","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.60943,1.75,0.031,1343,0.201,"ENPP1, GYS1, PYGL, UGDH, UXS1, HK1, PYGM, PGM2, PGM2L1, PGM1",1.50863830616573,0.696803942579511,TRUE
+"H2126","Input","KEGG_STEROID_BIOSYNTHESIS",0.62732,1.8,0.0163,831,0.245,"MSMO1, DHCR24, SC5D, NSDHL, FDFT1, DHCR7",1.78781239559604,0.610833915635468,TRUE
+"H2126","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.55637,1.63,0.0421,521,0.223,"SULT2B1, SRD5A3, CYP1B1, COMT, CYP21A2",1.37571790416433,0.651695136951839,TRUE
+"H2126","Input","KEGG_SULFUR_METABOLISM",0.78472,2.28,0,216,0.0466,"SULT2B1, SULT1A3, PAPSS2",Inf,1.33161408331,TRUE
+"H2126","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.49155,-1.49,0.0836,7521,0.594,"SSB, TRIM21, C1S, ACTN1, C3, C1R",1.07779372256098,0.226213555018806,FALSE
+"H2126","Input","KEGG_TASTE_TRANSDUCTION",0.32059,0.923,0.528,209,0.802,"CACNA1A",0.277366077466188,0.0958256317158365,FALSE
+"H2126","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.59573,1.73,0.0307,1468,0.189,"IDI1, PDSS2, FDPS, MVD, PMVK, MVK, HMGCR",1.51286162452281,0.723538195826756,TRUE
+"H2126","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.2805,-0.876,0.593,6878,0.92,"CREBBP, SMAD4, SMAD1, RBL1, BMPR2, SMAD3, ACVR2A, TGFBR2, MYC, TGFB2, INHBA, FST, THBS1, THBS2",0.226945306635737,0.0362121726544447,FALSE
+"H2126","Input","KEGG_THYROID_CANCER",-0.35137,-1.08,0.295,7959,0.719,"TPR, TCF7L2, MYC, CCND1, TP53",0.530177984021837,0.143271109617117,FALSE
+"H2126","Input","KEGG_TIGHT_JUNCTION",0.26989,0.774,0.749,1863,1,"CLDN3, MYH3, CLDN7, EPB41L3, EPB41L1, TJP3, RAB13, CGN, CTNNA1, LLGL2, PRKCD, AMOTL1, CTNNA2, VAPA, OCLN, F11R, PATJ, EXOC4, AKT1, CTTN",0.125518182300534,0,FALSE
+"H2126","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.18618,-0.58,0.983,7601,1,"TOLLIP, TLR3, SPP1, IFNAR1, MAP2K6, JUN, CCL5, PIK3R3, CTSK",0.00744648216786438,0,FALSE
+"H2126","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.44076,-1.34,0.168,7325,0.657,"CYP1A1, WARS2, ALDH1B1, ALDH9A1, GCDH, KYNU, MAOB",0.774690718274137,0.182434630440219,FALSE
+"H2126","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.26787,0.769,0.754,1039,0.999,"CACNA1A, IRS2, PRKCD, HK1, PDX1",0.122628654130226,0.000434511774017692,FALSE
+"H2126","Input","KEGG_TYROSINE_METABOLISM",0.53264,1.54,0.059,487,0.3,"HGD, ALDH3B1, COMT, BUD23, ALDH1A3, METTL2B, GSTZ1",1.22914798835786,0.522878745280338,FALSE
+"H2126","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17534,-0.548,0.985,8256,1,"PTPRC, PAK2, NFAT5, JUN, PIK3R3, NFATC2",0.00656376950238827,0,FALSE
+"H2126","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.23048,0.672,0.883,3037,1,"FZR1, ANAPC11, SYVN1, MID1, UBE2Q1, BIRC2, PIAS3, HERC1, UBE4A, SMURF1, UBE2M, UBA7, RNF7, UBE2L3, XIAP, RCHY1, BRCA1, PPIL2, UBE2NL, CUL4A, CDC26, CUL4B, UBE2J1, UBE3C, MGRN1, UBE2N, NEDD4, CDC23, ANAPC4, CUL2, UBE2G2, UBE2A, CDC16, STUB1, ANAPC5, HERC4, ELOC, ITCH, UBE2G1, UBE2F, BIRC6, CUL1, TRIP12, TRIM37, ELOB, CBL, CUL7, UBE2Z, CUL3, HERC2, UBE2C, UBE2D2",0.0540392964224314,0,FALSE
+"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.34285,-1.05,0.345,6260,0.746,"PDHA1, PDHB, LARS2, BCAT1",0.462180904926726,0.127261172527331,FALSE
+"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.34823,-1.08,0.319,7932,0.719,"ACADSB, ALDH9A1, ACAA2, HMGCS2, BCAT1, OXCT1, IVD",0.496209316942819,0.143271109617117,FALSE
+"H2126","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.33844,0.963,0.475,1500,0.743,"ITPR1, ADCY5, PLA2G12A, PLA2G4A, CACNA1F, PRKCD, MYL6, GNA11, ROCK1",0.323306390375133,0.129011186239425,FALSE
+"H2126","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.20693,0.594,0.962,2718,0.993,"AQP3, ARHGDIB, RAB11A, NSF, RAB11B, DCTN5, DYNC1LI2, DYNC1H1, RAB5B",0.0168249279621871,0.00305075150461883,FALSE
+"H2126","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23268,0.666,0.897,2337,1,"PLA2G12A, CASP9, PLA2G4A, RAC2, PXN, RAC3, CHP1, MAPK13, RAC1, AKT1, MAPK3, HSPB1, SPHK2, MAPK12",0.0472075569559079,0,FALSE
+"H2126","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.24131,0.699,0.847,1995,1,"KDELR3, TCIRG1, PDIA4, ERO1A, KDELR1, SEC61B, ATP6V0A1, ATP6V0D1, ATP6V1B1, ATP6V0C",0.0721165896692931,0,FALSE
+"H2126","Input","KEGG_VIRAL_MYOCARDITIS",0.38191,1.11,0.287,528,0.597,"MYH3, CASP9, CD40, ITGB2, RAC2, BID",0.542118103266008,0.224025668870631,FALSE
+"H2126","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.30079,-0.923,0.44,6878,0.923,"CREBBP, SMAD4, CACYBP, SIAH1, CTBP2, PLCB2, PLCB3, CAMK2D, WNT5A, TBL1X, TBL1XR1, LRP6, SMAD3, PRKCB, FZD1, TCF7L2, CAMK2B, MYC, FOSL1, NFAT5, CCND1, JUN, FZD7, TP53, NFATC2, CAMK2G",0.356547323513813,0.0347982989740879,FALSE
+"H3255","Input","KEGG_ABC_TRANSPORTERS",-0.34284,-1.04,0.379,9404,0.817,"ABCA1, ABCB4, ABCD1, ABCG2",0.421360790031928,0.0877779434675845,FALSE
+"H3255","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.22699,0.685,0.885,2513,0.936,"CEBPA, CCND1, RUNX1, BAD, TCF7L1, STAT3, RARA, IKBKG, HRAS, AKT1, TCF7L2, PIK3R3, IKBKB",0.0530567293021746,0.0287241512618947,FALSE
+"H3255","Input","KEGG_ADHERENS_JUNCTION",0.2297,0.702,0.873,957,0.925,"EGFR, LMO7, FGFR1, NECTIN4, EP300, AFDN, ERBB2, CTNNB1",0.0589857562944303,0.0338582672609674,FALSE
+"H3255","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.18008,-0.551,0.989,7785,1,"JAK2, CPT1C, PTPN11, ACACB, TRAF2, CAMKK2, SLC2A1, MAPK8, MAPK10, PRKCQ, IRS2",0.0048037084028206,0,FALSE
+"H3255","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32832,-0.989,0.397,9035,0.827,"ABAT, NIT2, GFPT2, GLUD2",0.401209493236885,0.0824944904474534,FALSE
+"H3255","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.31997,-0.972,0.438,8484,0.807,"PIK3CB, SFN, ATP1B3, IRS2",0.3585258894959,0.0931264652779296,FALSE
+"H3255","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.45433,1.38,0.11,71,0.598,"FADS2, PLA2G4A",0.958607314841775,0.223298816011589,FALSE
+"H3255","Input","KEGG_ALZHEIMERS_DISEASE",-0.15801,-0.463,0.998,6846,1,"GSK3B, NDUFA9, CASP3, PLCB3, ATP5F1A, NDUFS2, NDUFB7, UQCR10, UQCRQ, MAPK3, CASP9, CHP1, ATP5F1C, GNAQ, GRIN1, NAE1, PLCB2, ATF6, ATP5F1E, CAPN1, ATP5PB, CASP7, PPP3CC, CYC1, PLCB4, NDUFA2, MAPT, LPL, IDE, LRP1, PSEN2, FADD, CACNA1F, SNCA",0.000869458712628891,0,FALSE
+"H3255","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.47743,-1.46,0.105,8698,0.768,"LARS2, DARS2, WARS2, SEPSECS, CARS2",0.978810700930062,0.114638779968488,FALSE
+"H3255","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.29991,-0.902,0.508,8555,0.847,"GNPDA1, GPI, FPGT, PGM2, GNE, UAP1, GFPT2, PGM1, GALK2",0.294136287716081,0.0721165896692931,FALSE
+"H3255","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.40337,-1.23,0.205,9454,0.664,"MAP2K6, NEFL, PRPH, PRPH2, NEFH, TP53",0.688246138944246,0.177831920631982,FALSE
+"H3255","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.25406,-0.765,0.732,8500,0.876,"RFX5, CTSL, HSP90AB1, RFXAP, HSPA2, NFYA, CD74",0.135488918941608,0.0574958938319193,FALSE
+"H3255","Input","KEGG_APOPTOSIS",-0.29435,-0.871,0.569,7123,0.854,"BAX, EXOG, CASP9, RELA, CHP1, CHUK, TNFRSF10C, DFFB, IRAK1, XIAP, CAPN1, DFFA, TRAF2, IRAK3, CASP7, PIK3CB, PPP3CC, ATM, IRAK2, IRAK4, BIRC2, TNFRSF10B, TNFRSF10D, FADD, TP53",0.244887733604929,0.068542129310995,FALSE
+"H3255","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.40376,1.21,0.239,279,0.495,"GGT5, PTGS2, PLA2G4A, GGT1",0.621602099051862,0.305394801066431,FALSE
+"H3255","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.40906,1.24,0.203,1416,0.553,"ARG2, PRODH, PRODH2, ODC1, ALDH2, PYCR1, GLUL, GAMT, ALDH3A2, GLS, GLS2, OAT, MAOA, PYCR2, CKB, ALDH4A1",0.692503962086787,0.257274868695302,FALSE
+"H3255","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.58775,-1.78,0.0344,8939,0.763,"SLC8A1, CACNA2D1, ITGB3, LEF1, ITGB1, CDH2, CACNA1F, ITGA5, ITGB8, ITGA6, DES, DSC2, DSG2",1.46344155742847,0.11747546204512,FALSE
+"H3255","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.3471,1.09,0.313,1816,0.649,"ALDH2, ALDH3A2, UGDH",0.504455662453552,0.187755303199631,FALSE
+"H3255","Input","KEGG_AXON_GUIDANCE",-0.28258,-0.869,0.61,8086,0.846,"PAK2, SRGAP2, SRGAP3, PAK3, SEMA5A, FYN, EPHB6, SRGAP1, NCK1, EFNA5, GNAI2, PPP3CC, RAC2, EFNB2, NCK2, CXCR4, RASA1, NFATC1, ABLIM3, SEMA7A, ITGB1, NFAT5, L1CAM, SEMA3F, EFNB1, ROBO1",0.214670164989233,0.0726296369609765,FALSE
+"H3255","Input","KEGG_BASAL_CELL_CARCINOMA",-0.62416,-1.88,0.0156,9283,0.971,"LEF1, FZD7, WNT10A, WNT7A, GLI2, TP53",1.80687540164554,0.0127807700919951,FALSE
+"H3255","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.12719,-0.376,1,7915,1,"TBPL1, GTF2F2, GTF2F1, GTF2B",0,0,FALSE
+"H3255","Input","KEGG_BASE_EXCISION_REPAIR",0.24011,0.729,0.783,2064,0.924,"LIG3, POLE2, POLE4, XRCC1, POLE, POLE3, POLB, POLD4",0.106238237942057,0.0343280287798933,FALSE
+"H3255","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29132,-0.866,0.6,8443,0.83,"SRM, ABAT, ALDH1B1, ALDH7A1",0.221848749616356,0.0809219076239261,FALSE
+"H3255","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.42747,1.28,0.161,1479,0.602,"FADS2, ACAA1, ACOT2, PECR, HSD17B12, SCD5, ACOX1",0.79317412396815,0.220403508742175,FALSE
+"H3255","Input","KEGG_BLADDER_CANCER",-0.29424,-0.881,0.579,8246,0.857,"TYMP, RASSF1, MMP1, MAP2K1, RAF1, ARAF, CDKN2A, TP53",0.237321436272564,0.0670191780768018,FALSE
+"H3255","Input","KEGG_BUTANOATE_METABOLISM",0.3346,1.02,0.377,1824,0.727,"OXCT1, ALDH2, HMGCS1, ALDH3A2, ALDH5A1, ACAT2, BDH2, EHHADH",0.423658649794207,0.138465589140962,FALSE
+"H3255","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.4408,-1.32,0.137,8461,0.664,"SOS1, PIK3CB, PPP3CC, RAC2, BCL10, INPP5D, MAP2K1, RAF1, NFATC1, CARD11, MALT1, BLNK, NFAT5, CD79A, PLCG2, CD79B",0.863279432843593,0.177831920631982,FALSE
+"H3255","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.23461,-0.705,0.823,8456,0.94,"F2R, CD38, PPP3CC, PHKA1, PLCB4, ATP2B2, ATP2B4, PHKB, SLC8A1, BST1, PHKG2, TRPC1, MYLK, PDE1C, CACNA1F, PLCD3, PLCG2",0.0846001647877302,0.0268721464003014,FALSE
+"H3255","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.32017,-0.972,0.437,8541,0.807,"CYC1, ATP1B3, SLC8A1, CACNA2D1, CACNA1F, TPM2",0.359518563029578,0.0931264652779296,FALSE
+"H3255","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.30421,0.954,0.504,1197,0.782,"ICAM1, SDC2, CLDN3, VCAN, CADM1, SDC1, CDH15, CDH3, OCLN, CLDN4, SDC3",0.297569463554475,0.106793246940152,FALSE
+"H3255","Input","KEGG_CELL_CYCLE",-0.25617,-0.783,0.748,8299,0.863,"ESPL1, CDK2, YWHAQ, CDC26, PLK1, ATM, CHEK1, SMC1B, SFN, CDK1, CDKN2C, YWHAZ, TFDP1, TFDP2, TGFB2, CDKN2A, ORC3, TP53",0.126098402135539,0.0639892042847904,FALSE
+"H3255","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.29396,-0.879,0.552,8412,0.849,"GNAI2, CXCL5, SOS1, PIK3CB, GRK6, RAC2, BCAR1, CCR4, CXCR4, PLCB4, SHC4, MAP2K1, CSK, RAF1, ELMO1, DOCK2, WAS, CCR10, CCR9, RASGRP2",0.258060922270801,0.0710923097560473,FALSE
+"H3255","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.29429,-0.903,0.538,7990,0.857,"PTPN11, SHC1, CBLB, SOS1, PIK3CB, STAT5A, SHC4, MAP2K1, RAF1, ARAF, TGFB2, CDKN2A, CBL, TP53",0.269217724333611,0.0670191780768018,FALSE
+"H3255","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.26201,0.802,0.705,2625,0.916,"CRY1, CLOCK, PER1, ARNTL",0.151810883008601,0.0381045263321496,FALSE
+"H3255","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.40662,1.26,0.173,2829,0.561,"DLST, ACO1, MDH2, SDHA, OGDHL, OGDH, IDH2, IDH1, SUCLG2, PCK2, DLD, SUCLG1",0.761953896871205,0.251037138743839,FALSE
+"H3255","Input","KEGG_COLORECTAL_CANCER",-0.42461,-1.28,0.175,8484,0.667,"PIK3CB, RAC2, APPL1, MAP2K1, RAF1, ARAF, MAPK8, LEF1, MAPK10, TGFB2, TP53, BIRC5",0.756961951313706,0.175874166083451,FALSE
+"H3255","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.31916,0.987,0.415,1039,0.743,"PLAT, THBD, TFPI, PLAUR, CD55, C4A, F9, CFI, F8",0.381951903287907,0.129011186239425,FALSE
+"H3255","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.35588,-1.08,0.326,6843,0.828,"ADI1, MAT1A, MAT2B, TAT, APIP, GOT2, MAT2A, AHCY, AHCYL1, SDS, SRM, MTAP",0.486782399932061,0.0819696632151199,FALSE
+"H3255","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.27157,0.844,0.664,1302,0.877,"LIFR, EGFR, OSMR, CSF1, TGFB1, CCL28, TNFRSF21, IL1R1, IFNGR1, IL25, VEGFA, LTBR, TNFRSF19, TNFRSF1A, IL1RAP",0.177831920631982,0.0570004066339595,FALSE
+"H3255","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.42134,-1.3,0.143,8691,0.679,"POLR3A, POLR3B, IL6, TBK1, ZBP1, IL18, PYCARD, TREX1",0.844663962534938,0.168130225719498,FALSE
+"H3255","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.47347,-1.44,0.11,8939,0.713,"SLC8A1, CACNA2D1, ITGB3, ITGB1, TGFB2, CACNA1F, ITGA5, TPM2, ITGB8, ITGA6, DES",0.958607314841775,0.146910470148134,FALSE
+"H3255","Input","KEGG_DNA_REPLICATION",0.39988,1.23,0.204,3839,0.53,"SSBP1, POLE2, POLE4, RPA3, POLE, POLE3, POLD4, RFC3, LIG1, MCM4, MCM3, RFC1, MCM6, POLA2, PCNA, MCM7, PRIM1",0.690369832574101,0.275724130399211,FALSE
+"H3255","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.34053,-1.06,0.339,8461,0.821,"SOS1, NOTCH2, MAP2K1, ETS1, NOTCH1",0.469800301796918,0.0856568428805592,FALSE
+"H3255","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.48669,-1.45,0.095,8919,0.738,"ALDH3B1, GSTM3, GSTM2, ALDH1A3, GSTM1, GSTO1, ALDH3A1, GSTM4, GSTP1",1.02227639471115,0.131943638176958,FALSE
+"H3255","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.3388,-1,0.429,7770,0.833,"UMPS, CES1, CES2, TYMP, GMPS, HPRT1, IMPDH2, UCK2, CDA",0.367542707815276,0.0793549985932124,FALSE
+"H3255","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43397,-1.35,0.136,8767,0.726,"COL5A2, COL6A2, HSPG2, COL3A1, ITGB3, COL6A1, VTN, COL5A1, ITGB1, LAMA3, LAMA4, ITGA5, COL4A1, ITGB8, COL1A2, COL4A6, ITGA6, COL4A2",0.866461091629782,0.139063379299906,FALSE
+"H3255","Input","KEGG_ENDOCYTOSIS",-0.26473,-0.794,0.715,7952,0.852,"STAM, DNM2, RAB11A, PIP4K2B, CHMP2A, PSD, EHD2, CBLB, WWP1, VTA1, F2R, EHD1, PDCD6IP, GRK6, IGF1R, SH3GLB1, EHD3, ASAP1, CHMP2B, CXCR4, DNM1L, EHD4, ARAP2, VPS4B, SH3GLB2, SNF8, GIT2, ASAP2, HSPA2, VPS36, RAB11FIP2, PIP5K1A, ACAP2, CBL, DNM1, DAB2",0.145693958198919,0.0695604052332999,FALSE
+"H3255","Input","KEGG_ENDOMETRIAL_CANCER",-0.27938,-0.827,0.651,8461,0.816,"SOS1, PIK3CB, ILK, MAP2K1, RAF1, ELK1, ARAF, LEF1, TP53",0.186419011431808,0.0883098412461389,FALSE
+"H3255","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.19706,-0.607,0.951,8738,1,"HBEGF, CSK, MAPK8, MAP2K4, MAPK10, PLCG2",0.0218194830625861,0,FALSE
+"H3255","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.29974,-0.903,0.526,8052,0.857,"SHC1, PAK2, PAK3, ABL2, CBLB, NCK1, SOS1, PIK3CB, NCK2, HBEGF, MAP2K7, STAT5A, SHC4, MAP2K1, RAF1, ELK1, ARAF, MAPK8, MAP2K4, MAPK10, CBL, PLCG2",0.279014255846261,0.0670191780768018,FALSE
+"H3255","Input","KEGG_ETHER_LIPID_METABOLISM",0.39645,1.19,0.237,1097,0.513,"PLA2G4A, LPCAT2, PLPP1, PLA2G12A, PLPP2, PLD1, PAFAH2",0.625251653989896,0.289882634888184,FALSE
+"H3255","Input","KEGG_FATTY_ACID_METABOLISM",0.35348,1.08,0.327,2499,0.652,"ALDH2, ACSL5, ECI2, ACAA1, GCDH, ALDH3A2, ACAT2, ACOX1, ACSL1, ACADSB, EHHADH, ACSL4, ACADVL, ECHS1, ACOX3",0.485452247339714,0.18575240426808,FALSE
+"H3255","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.33913,-1.03,0.362,8221,0.808,"FYN, PLA2G2D, SOS1, PIK3CB, LAT, RAC2, MAP2K7, INPP5D, MAP2K1, RAF1, MAPK8, MAP2K4, MAPK10, MAP2K6, PLCG2, PLA2G6",0.441291429466834,0.0925886392254138,FALSE
+"H3255","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.30258,-0.919,0.498,8331,0.874,"VASP, PIK3CB, LAT, RAC2, ASAP1, DNM1L, INPP5D, MAP2K1, RAF1, DOCK2, WAS, ASAP2, PIP5K1A, DNM1, PLCG2, PLA2G6",0.302770657240282,0.058488567365597,FALSE
+"H3255","Input","KEGG_FOCAL_ADHESION",-0.41381,-1.26,0.168,7690,0.685,"RAC3, RAP1B, LAMB4, ZYX, FLNB, ITGA3, RAPGEF1, XIAP, SHC1, PAK2, COL6A3, PAK3, FYN, COL1A1, VASP, HGF, SOS1, PIK3CB, FLNA, ILK, IGF1R, RAC2, DIAPH1, VCL, BCAR1, COL5A2, DOCK1, COL6A2, SHC4, MAP2K1, RAF1, ELK1, COL3A1, BIRC2, ITGB3, MAPK8, COL6A1, VTN, MYLK, COL5A1, FLNC, MAPK10, ITGB1, LAMA3, LAMA4, CAV1, ITGA5, COL4A1, ITGB8, PARVB, COL1A2, COL4A6, ITGA6, CAV2, COL4A2",0.774690718274137,0.164309428507574,FALSE
+"H3255","Input","KEGG_FOLATE_BIOSYNTHESIS",0.39984,1.23,0.213,2958,0.53,"GGH, ALPI, ALPP, ALPG, DHFR",0.671620396561262,0.275724130399211,FALSE
+"H3255","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.2781,0.847,0.617,173,0.887,"FBP1, FBP2",0.209714835966758,0.0520763801682736,FALSE
+"H3255","Input","KEGG_GALACTOSE_METABOLISM",-0.35333,-1.06,0.351,8632,0.821,"PGM2, PGM1, GALK2, PFKP",0.454692883534176,0.0856568428805592,FALSE
+"H3255","Input","KEGG_GAP_JUNCTION",0.19907,0.617,0.951,1186,0.959,"EGFR, GUCY1A1, GJA1, PLCB1, ITPR1, MAPK7, ITPR3",0.0218194830625861,0.0181813928293364,FALSE
+"H3255","Input","KEGG_GLIOMA",-0.38066,-1.15,0.261,8461,0.736,"SOS1, PIK3CB, IGF1R, SHC4, MAP2K1, RAF1, ARAF, CDKN2A, PLCG2, TP53",0.583359492661719,0.133122185662501,FALSE
+"H3255","Input","KEGG_GLUTATHIONE_METABOLISM",0.34208,1.06,0.344,423,0.676,"GGT5, GSTA5, ODC1, GGT1, GCLC, MGST1",0.46344155742847,0.170053304058364,FALSE
+"H3255","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.23401,-0.712,0.838,8741,0.939,"DGKD, LPL, ALDH1B1, ALDH7A1, GK2, AGPAT4",0.0767559813697235,0.0273344077338891,FALSE
+"H3255","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.27066,0.814,0.709,2117,0.907,"PLA2G4A, LPCAT2, PEMT, GPD1L, PLPP1, PLA2G12A, PLPP2, PLD1, CHKB, LPGAT1, MBOAT1, LPCAT1, LYPLA2, LPCAT3, PLA2G15, GPD2, PLPP3, CDS1",0.149353764816933,0.0423927129399047,FALSE
+"H3255","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.29789,0.943,0.495,1288,0.79,"PSPH, GCAT, GAMT, MAOA, CTH",0.305394801066431,0.102372908709559,FALSE
+"H3255","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.32917,-1,0.421,8556,0.833,"GPI, PGM2, PGK1, ALDH3B1, PKM, ALDH1B1, PGAM1, PGAM4, ALDH1A3, PKLR, PGM1, ALDH7A1, PFKP, ALDH3A1",0.375717904164332,0.0793549985932124,FALSE
+"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34442,-1.03,0.375,8563,0.808,"CSGALNACT1, CHST13, CHST7, XYLT1, CHST3",0.425968732272281,0.0925886392254138,FALSE
+"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.28566,0.878,0.557,2422,0.869,"HS6ST2, XYLT2, EXT2, GLCE, NDST1, B4GALT7",0.254144804826271,0.0609802235513335,FALSE
+"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.4081,1.27,0.174,2980,0.568,"FUT8, B3GNT2, B4GALT3, B4GALT1, B4GAT1",0.7594507517174,0.245651664288981,FALSE
+"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.58563,1.77,0.0302,1870,0.289,"SGSH, GUSB, GNS, HEXB, HEXA, NAGLU, HGSNAT",1.51999305704285,0.539102157243452,FALSE
+"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.43302,-1.32,0.17,9836,0.664,"B4GALNT1",0.769551078621726,0.177831920631982,FALSE
+"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.38661,1.21,0.226,1666,0.495,"FUT1, HEXB, HEXA, NAGA",0.645891560852599,0.305394801066431,FALSE
+"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.41006,-1.25,0.178,9621,0.662,"ABO, B3GALT5",0.749579997691106,0.1791420105603,FALSE
+"H3255","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.5379,1.65,0.049,2265,0.361,"PIGA, PIGH, PIGS, PIGO, PIGT, PIGK, GPAA1",1.30980391997149,0.442492798094342,FALSE
+"H3255","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.43088,1.35,0.132,3361,0.586,"ACO1, MDH2, MTHFD1L, GRHPR, MTHFD1, CS",0.87942606879415,0.232102383981909,FALSE
+"H3255","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.2673,-0.816,0.654,7175,0.818,"MAP2K2, MAPK3, PLA2G2A, MMP2, MAP3K3, ADCY3, ADCY8, PTK2B, GNAQ, ADCY9, SRC, PLCB2, MAP2K3, MAP3K2, PLA2G2D, SOS1, HBEGF, MAP2K7, PLCB4, MAP2K1, RAF1, ELK1, MAPK8, MAP2K4, MAPK10, MAP2K6, CACNA1F, MMP14, PLA2G6",0.184422251675733,0.087246696328677,FALSE
+"H3255","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.57521,-1.75,0.023,9204,0.572,"CSNK1E, WNT10A, WNT7A, GLI2",1.63827216398241,0.242603971206976,FALSE
+"H3255","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.33087,-0.993,0.442,8470,0.833,"CD38, CD59, CD14, IL6, ITGB3, ITGA5, ANPEP, ITGA6, CD33",0.354577730650908,0.0793549985932124,FALSE
+"H3255","Input","KEGG_HISTIDINE_METABOLISM",-0.38446,-1.15,0.272,8384,0.736,"LCMT1, MAOB, ALDH3B1, ALDH1B1, ALDH1A3, ALDH7A1, LCMT2, ALDH3A1",0.565431095965801,0.133122185662501,FALSE
+"H3255","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.23296,-0.7,0.826,8074,0.937,"RAD54B, BRCA2, RAD51, TOP3B, RAD52",0.0830199526796178,0.0282604091122217,FALSE
+"H3255","Input","KEGG_HUNTINGTONS_DISEASE",-0.1595,-0.475,0.996,6266,1,"COX7B, NDUFA10, NDUFB3, GPX1, NDUFS1, SDHD, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, DNAL4, SLC25A4, NDUFA9, CASP3, PLCB3, ATP5F1A, DNAL1, NDUFS2, NDUFB7, BAX, UQCR10, UQCRQ, CASP9, SLC25A5, ATP5F1C, GNAQ, GRM5, GRIN1, PLCB2, HTT, DCTN2, TBPL1, ATP5F1E, SP1, ATP5PB, SOD1, PPARG, CYC1, DCTN4, DCTN1, PLCB4, NDUFA2, CREB5, TGM2, TP53",0.00174066157630127,0,FALSE
+"H3255","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.52789,-1.65,0.0564,8939,0.64,"SLC8A1, IL6, CACNA2D1, ITGB3, ITGB1, TGFB2, CACNA1F, ITGA5, TPM2, ITGB8, ITGA6, DES, ACE",1.24872089601666,0.193820026016113,FALSE
+"H3255","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.29939,-0.904,0.53,8484,0.881,"PIK3CB, INPP1, PIK3C3, ITPK1, PLCB4, INPPL1, IMPA1, PIP5K1A, PLCD3, PLCG2",0.275724130399211,0.0550240915879521,FALSE
+"H3255","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.28823,-0.857,0.588,7895,0.807,"EIF4EBP1, RAPGEF1, SHC1, PHKA2, FOXO1, CBLB, ACACB, RPS6, SOS1, PIK3CB, PHKA1, PHKB, SHC4, INPP5D, MAP2K1, RAF1, ELK1, PHKG2, ARAF, MAPK8, PKLR, MAPK10, MKNK1, CBL, SOCS4, IRS2",0.230622673923862,0.0931264652779296,FALSE
+"H3255","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50237,-1.55,0.0691,8733,0.73,"CXCR4, IL6, CCR10, CCR9, CD40",1.1605219526258,0.136677139879544,FALSE
+"H3255","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.29048,0.885,0.593,1009,0.87,"LIFR, OSMR, CCND1, SPRY2, STAM2, EP300, IFNGR1, STAT2, PIAS3",0.226945306635737,0.0604807473813815,FALSE
+"H3255","Input","KEGG_LEISHMANIA_INFECTION",0.3775,1.14,0.26,787,0.585,"PTGS2, MYD88, MAPK12, TGFB1, TLR2, MAPK13, IFNGR1",0.585026652029182,0.23284413391782,FALSE
+"H3255","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.23998,0.738,0.824,1123,0.936,"ICAM1, CLDN3, MAPK12, MAPK13, VAV1, AFDN, ARHGAP35, CTNNB1, OCLN, CLDN4",0.0840727883028842,0.0287241512618947,FALSE
+"H3255","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.32649,1.01,0.418,1824,0.73,"ALDH2, ALDH3A2, EHHADH",0.378823718224965,0.136677139879544,FALSE
+"H3255","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.38646,-1.17,0.242,9884,0.733,"PLA2G6",0.616184634019569,0.134896025358872,FALSE
+"H3255","Input","KEGG_LONG_TERM_DEPRESSION",0.2406,0.741,0.759,1186,0.945,"PLA2G4A, GUCY1A1, GNAO1, PLCB1, ITPR1, PLA2G12A, ITPR3",0.11975822410452,0.0245681914907371,FALSE
+"H3255","Input","KEGG_LONG_TERM_POTENTIATION",0.16611,0.516,0.989,1186,0.992,"EP300, PLCB1, ITPR1, ATF4, PPP3R1, ITPR3",0.0048037084028206,0.00348832784582135,FALSE
+"H3255","Input","KEGG_LYSINE_DEGRADATION",0.274,0.834,0.616,1537,0.882,"ALDH2, AASS, DLST, GCDH, ALDH3A2, OGDHL, ACAT2, NSD3, OGDH, SETMAR",0.210419287835575,0.0545314148681803,FALSE
+"H3255","Input","KEGG_LYSOSOME",0.59532,1.87,0.0175,1669,0.305,"CTSE, NPC2, NAPSA, LGMN, SGSH, CTSH, LAMP3, CTSC, FUCA1, GALC, PSAP, CTSZ, GUSB, CD63, NEU1, MANBA, ASAH1, GNS, ACP2, GNPTG, ARSA, SCARB2, SMPD1, MFSD8, CLN3, AGA, CLTA, ACP5, MAN2B1, CTSS, NAGPA, HEXB, SORT1, DNASE2, GM2A, HEXA, CTSA, GNPTAB, M6PR, SLC11A2, NAGA, MCOLN1",1.75696195131371,0.515700160653214,FALSE
+"H3255","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.33904,-1.01,0.384,8461,0.84,"SOS1, ATF2, PPP3CC, FLNA, RAC2, STMN1, MAP2K7, NLK, CD14, RASA1, MAP2K1, MAPT, ELK4, RAF1, CACNA2D1, ELK1, DUSP4, DUSP1, MAPK8, PTPN7, MAP2K4, MAP4K4, NFKB2, FLNC, MAPK10, RELB, TGFB2, MAP2K6, HSPA2, CACNA1F, MKNK1, STK4, MOS, FGF13, FGF2, PLA2G6, RASGRP2, TP53",0.415668775632469,0.0757207139381184,FALSE
+"H3255","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.2755,-0.827,0.646,9338,0.816,"PKLR",0.189767482004916,0.0883098412461389,FALSE
+"H3255","Input","KEGG_MELANOGENESIS",-0.22541,-0.684,0.861,6728,0.951,"PRKCB, GNAI3, GSK3B, PLCB3, MAP2K2, MAPK3, ADCY3, ADCY8, GNAQ, ADCY9, PLCB2, DCT, FZD2, GNAI2, PLCB4, MAP2K1, RAF1, LEF1, FZD7, WNT10A, WNT7A",0.0649968485463452,0.0218194830625861,FALSE
+"H3255","Input","KEGG_MELANOMA",-0.42238,-1.32,0.135,8460,0.664,"HGF, PIK3CB, IGF1R, MAP2K1, RAF1, ARAF, CDKN2A, FGF13, FGF2, TP53",0.869666231504994,0.177831920631982,FALSE
+"H3255","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42542,-1.29,0.157,8919,0.672,"ALDH3B1, GSTM3, GSTM2, ALDH1A3, GSTM1, GSTO1, ALDH3A1, GSTM4, GSTP1",0.804100347590766,0.172630726946175,FALSE
+"H3255","Input","KEGG_MISMATCH_REPAIR",0.39045,1.21,0.189,3752,0.495,"SSBP1, RPA3, POLD4, RFC3, LIG1, RFC1, EXO1, MSH3, PCNA, PMS2",0.723538195826756,0.305394801066431,FALSE
+"H3255","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.14959,-0.45,1,6026,1,"EIF4E2, AKT2, EIF4B, RPS6KA2, RPS6KB1, ULK3, RPS6KA1, MAPK3, TSC2, TSC1, EIF4EBP1, RPS6, PIK3CB, CAB39L",0,0,FALSE
+"H3255","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.30955,-0.935,0.483,8461,0.85,"SOS1, PIK3CB, LAT, PPP3CC, LCK, RAC2, SHC4, MAP2K1, RAF1, SH3BP2, NFATC1, ARAF, TNFRSF10B, TNFRSF10D, ICAM2, NFAT5, PRF1, PLCG2",0.316052869248488,0.0705810742857073,FALSE
+"H3255","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.35608,-1.07,0.355,7196,0.834,"PLG, GRM5, GRIN1, PRSS3, NR3C1, F2, F2R, F2RL1",0.449771646944906,0.0788339493622613,FALSE
+"H3255","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.31831,-0.984,0.436,7848,0.823,"YWHAB, IRAK1, RAPGEF1, MAGED1, PTPN11, FOXO3, SHC1, YWHAQ, IRAK3, SOS1, PIK3CB, MAP2K7, RIPK2, SHC4, MAP2K1, IRAK2, CSK, YWHAZ, RAF1, IRAK4, MAPK8, MAPK10, PLCG2, NGFR, IRS2, TP53",0.360513510731414,0.0846001647877302,FALSE
+"H3255","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.41951,1.27,0.168,364,0.568,"ENPP3, NAMPT, NT5E",0.774690718274137,0.245651664288981,FALSE
+"H3255","Input","KEGG_NITROGEN_METABOLISM",-0.51133,-1.52,0.0813,9087,0.734,"CA9, CA12, GLUD2, CA2",1.08990945440593,0.134303940083929,FALSE
+"H3255","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.40053,-1.19,0.246,7187,0.708,"MAPK3, RELA, CHUK, TAB1, CASP1, PYDC1, XIAP, CARD8, TAB3, HSP90AB1, RIPK2, IL6, BIRC2, MAPK8, TNFAIP3, MAPK10, SUGT1, IL18, PYCARD",0.609064892896621,0.149966742310231,FALSE
+"H3255","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.46002,-1.38,0.109,6350,0.692,"DCLRE1C, RAD50, LIG4, POLL, NHEJ1, PRKDC, FEN1",0.962573502059376,0.159893905543242,FALSE
+"H3255","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.35828,-1.1,0.294,8445,0.797,"RASSF1, SOS1, PIK3CB, MAP2K1, RAF1, ARAF, CDKN2A, STK4, PLCG2, TP53",0.531652669587843,0.0985416786038876,FALSE
+"H3255","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.21185,0.652,0.923,3247,0.94,"NCOR2, EP300, HES1, DTX2, NOTCH3, CTBP1, HDAC2, MAML2, PSEN1, CREBBP, SNW1, DVL2, ADAM17, NUMB",0.0347982989740879,0.0268721464003014,FALSE
+"H3255","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.29256,0.903,0.55,3699,0.846,"POLE2, POLE4, ERCC8, RPA3, MNAT1, POLE, DDB2, POLE3, POLD4, RFC3, GTF2H5, DDB1, LIG1, GTF2H2, RFC1, ERCC2, GTF2H1, PCNA, ERCC4, CDK7",0.259637310505756,0.0726296369609765,FALSE
+"H3255","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39376,1.22,0.201,1704,0.529,"FUT8, ST6GAL1, MGAT4A, MAN1A1, MGAT1, MAN2A2, MOGS, MAN1B1, ALG12, MGAT2, B4GALT3",0.696803942579511,0.276544327964814,FALSE
+"H3255","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.2352,-0.722,0.831,7253,0.933,"ADCY3, CNGB1, PDE1C",0.080398976215889,0.0301183562535,FALSE
+"H3255","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.31526,-0.948,0.482,7361,0.833,"MTFMT, GART, ATIC, MTHFR, ALDH1L1",0.31695296176115,0.0793549985932124,FALSE
+"H3255","Input","KEGG_OOCYTE_MEIOSIS",-0.26299,-0.782,0.727,6083,0.854,"PRKACB, MAD2L2, CDC16, CDC23, RPS6KA2, PPP2CB, CDC20, ANAPC4, PPP2CA, MAD2L1, PPP1CB, SKP1, SMC3, SMC1A, RPS6KA1, MAPK3, ADCY3, ADCY8, PTTG1, SGO1, CHP1, PPP2R5A, ADCY9, CUL1, CDC25C, YWHAB, PPP2R5D, FBXO5, SLK, ESPL1, CDK2, YWHAQ, CDC26, PPP3CC, PLK1, IGF1R, SMC1B, CDK1, PPP2R1B, MAP2K1, YWHAZ, MOS",0.138465589140962,0.068542129310995,FALSE
+"H3255","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.61298,1.86,0.0172,1326,0.227,"FUCA1, NEU1, MANBA, AGA, MAN2B1, HEXB, HEXA",1.76447155309245,0.643974142806877,TRUE
+"H3255","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.19406,-0.568,0.965,5496,1,"NDUFB5, NDUFB9, NDUFS8, NDUFA3, NDUFC1, NDUFS5, NDUFS4, UQCRC2, NDUFV2, NDUFS7, COX4I1, NDUFB4, COX7A2L, UQCRC1, COX11, NDUFA6, NDUFV1, ATP6V1H, COX7B, NDUFA11, NDUFA10, NDUFB3, NDUFS1, SDHD, COX17, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, ATP12A, NDUFA9, ATP5F1A, ATP6V1C1, NDUFS2, NDUFB7, UQCR10, UQCRQ, ATP5F1C, PPA1, ATP5MG, ATP5ME, ATP5F1E, COX15, TCIRG1, ATP5PB, CYC1, NDUFA2",0.0154726866562074,0,FALSE
+"H3255","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.76427,2.39,0,1130,0.0609,"GALNT10, GALNT8, GALNT3, GALNT5, GALNT12, GALNT4, GALNT11, C1GALT1, GALNT6, C1GALT1C1, GALNT1, GALNT13, GALNT7",Inf,1.21538270736712,TRUE
+"H3255","Input","KEGG_P53_SIGNALING_PATHWAY",-0.41325,-1.25,0.193,8360,0.662,"CDK2, IGFBP3, ATM, CHEK1, SFN, CDK1, RRM2B, PERP, TNFRSF10B, CDKN2A, SERPINE1, SERPINB5, TP53",0.714442690992226,0.1791420105603,FALSE
+"H3255","Input","KEGG_PANCREATIC_CANCER",-0.28805,-0.866,0.623,8296,0.83,"RAD51, PIK3CB, ARHGEF6, RAC2, MAP2K1, RAF1, ARAF, MAPK8, MAPK10, TGFB2, CDKN2A, TP53",0.20551195334083,0.0809219076239261,FALSE
+"H3255","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.64565,1.99,0.0167,1,0.419,"ENPP3",1.77728352885242,0.377785977033705,FALSE
+"H3255","Input","KEGG_PARKINSONS_DISEASE",-0.27526,-0.827,0.656,5677,0.816,"NDUFC1, NDUFS5, NDUFS4, UQCRC2, NDUFV2, NDUFS7, UBE2L3, COX4I1, NDUFB4, COX7A2L, UQCRC1, NDUFA6, NDUFV1, SLC25A6, COX7B, NDUFA10, NDUFB3, NDUFS1, SDHD, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, PARK7, SLC25A4, NDUFA9, CASP3, ATP5F1A, NDUFS2, NDUFB7, UQCR10, UQCRQ, CASP9, SLC25A5, ATP5F1C, ATP5F1E, SLC18A1, ATP5PB, CYC1, UBA1, NDUFA2, UCHL1, UBA7, SNCA",0.18309616062434,0.0883098412461389,FALSE
+"H3255","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.31893,-0.969,0.437,8221,0.8,"FYN, NCK1, YWHAQ, TUBA3C, TUBB4B, NCK2, CD14, YWHAZ, TUBAL3, WAS, ITGB1, TUBB6",0.359518563029578,0.0969100130080564,FALSE
+"H3255","Input","KEGG_PATHWAYS_IN_CANCER",-0.36469,-1.12,0.287,8201,0.788,"AXIN2, FZD2, CBLB, RAD51, VHL, CDK2, PPARG, TRAF2, RASSF1, HGF, SOS1, PIK3CB, TFG, IGF1R, RAC2, MMP1, APPL1, HSP90AB1, PAX8, STAT5A, MAP2K1, IL6, RAF1, SLC2A1, EGLN1, ARAF, BIRC2, MAPK8, LEF1, PML, NFKB2, ETS1, MAPK10, FADD, ITGB1, TGFB2, LAMA3, LAMA4, FZD7, WNT10A, CDKN2A, STK4, COL4A1, CBL, COL4A6, ITGA6, WNT7A, PLCG2, COL4A2, GLI2, FGF13, FGF2, GSTP1, TP53, BIRC5",0.542118103266008,0.103473782510445,FALSE
+"H3255","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.62983,1.94,0.00818,1816,0.365,"GUSB, DCXR, AKR1B1, UGDH",2.08724669632868,0.437707135543525,FALSE
+"H3255","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.29539,0.912,0.515,173,0.843,"FBP1, FBP2",0.288192770958809,0.0741724253752577,FALSE
+"H3255","Input","KEGG_PEROXISOME",0.44275,1.34,0.161,2246,0.574,"AMACR, ACSL5, SLC27A2, ECI2, ACAA1, ECH1, CROT, PECR, DHRS4, PEX16, PXMP4, PEX13, ACOT8, DECR2, PEX6, ACOX1, PEX2, ACSL1, PEX3, IDH2, EHHADH, ACSL4, IDH1, SCP2, MPV17, GSTK1, MVK, PEX26, PEX1",0.79317412396815,0.241088107602027,FALSE
+"H3255","Input","KEGG_PHENYLALANINE_METABOLISM",-0.51143,-1.56,0.0584,6281,0.784,"PRDX6, GOT1, MIF, TAT, GOT2, MAOB, ALDH3B1, ALDH1A3, ALDH3A1",1.2335871528876,0.105683937315562,FALSE
+"H3255","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.29616,-0.887,0.577,7419,0.855,"PIP5K1C, DGKB, DGKQ, PI4KB, PLCB2, SYNJ2, PIP4K2B, DGKE, PIK3CB, INPP1, PIK3C3, ITPK1, DGKD, PLCB4, INPPL1, INPP5D, IMPA1, PIP5K1A, PLCD3, PLCG2",0.238824186844269,0.0680338852718274,FALSE
+"H3255","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.36222,1.13,0.273,1507,0.587,"CP, GUSB, ALAD, BLVRA, HMOX1, CPOX",0.563837352959244,0.231361898752386,FALSE
+"H3255","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.45538,-1.38,0.117,9042,0.692,"SLC27A1, FABP7, LPL, SCD, ACADL, GK2, CYP27A1, PLTP, FABP5, OLR1, ANGPTL4",0.931814138253838,0.159893905543242,FALSE
+"H3255","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.56543,1.72,0.036,1022,0.307,"AMACR, AKR1D1, HSD3B7",1.44369749923271,0.512861624522813,FALSE
+"H3255","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.59581,-1.77,0.0261,8500,0.629,"RFX5, LCK, RFXAP, BLNK, CD79A, CD40",1.58335949266172,0.201349354554731,FALSE
+"H3255","Input","KEGG_PRION_DISEASES",-0.46458,-1.38,0.141,8221,0.692,"FYN, SOD1, MAP2K1, IL6, ELK1, PRNP, NOTCH1, NCAM1",0.85078088734462,0.159893905543242,FALSE
+"H3255","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.32346,-0.982,0.427,8360,0.813,"CDK2, GNAI2, CDC26, PIK3CB, PLK1, IGF1R, HSP90AB1, CDK1, MAP2K1, RAF1, ARAF, MAPK8, MAPK10, MOS",0.369572124974976,0.0899094544059319,FALSE
+"H3255","Input","KEGG_PROPANOATE_METABOLISM",0.31766,1,0.39,2228,0.732,"ALDH2, ALDH6A1, ALDH3A2, ACSS1, LDHB, ACAT2, ACSS2, EHHADH, HIBCH, PCCA, SUCLG2",0.408935392973501,0.135488918941608,FALSE
+"H3255","Input","KEGG_PROSTATE_CANCER",-0.24203,-0.739,0.825,8360,0.913,"CDK2, SOS1, PIK3CB, IGF1R, HSP90AB1, MAP2K1, RAF1, ARAF, CREB5, LEF1, GSTP1, TP53",0.0835460514500749,0.039529222465701,FALSE
+"H3255","Input","KEGG_PROTEASOME",-0.30056,-0.891,0.562,5469,0.859,"PSMD11, PSMB1, PSMA8, PSME3, PSMD8, PSMB4, PSMA7, PSMD13, PSMD7, PSME4, PSMA6, PSMA4, PSMD6, PSMD1, PSMB2, SEM1, PSME2, PSMD3, PSMD12, PSMB8, PSME1, POMP, PSMB10, PSMB9",0.250263684430939,0.0660068361687577,FALSE
+"H3255","Input","KEGG_PROTEIN_EXPORT",0.24929,0.785,0.733,2140,0.92,"SRP9, SEC62, IMMP2L, SRP14, OXA1L",0.134896025358872,0.0362121726544447,FALSE
+"H3255","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.47046,-1.41,0.131,9872,0.743,"GLUD2, CA2",0.882728704344236,0.129011186239425,FALSE
+"H3255","Input","KEGG_PURINE_METABOLISM",0.27566,0.86,0.599,1176,0.876,"ENPP3, ENTPD3, GUCY1A1, ENTPD5, PDE4A, NME4, NT5E, FHIT, POLE2, POLE4, PAPSS2, PDE2A, ENTPD6, CANT1, ADCY10",0.222573177610689,0.0574958938319193,FALSE
+"H3255","Input","KEGG_PYRIMIDINE_METABOLISM",0.25348,0.784,0.755,1136,0.907,"ENTPD3, ENTPD5, NME4, NT5E, TXNRD2, UPP1, POLE2, POLE4, UCK1, ENTPD6, CANT1, CTPS2",0.122053048370812,0.0423927129399047,FALSE
+"H3255","Input","KEGG_PYRUVATE_METABOLISM",0.24477,0.763,0.758,1366,0.918,"ALDH2, ME1, ALDH3A2, ACSS1, MDH2, LDHB, ACAT2, ACSS2",0.120330794367946,0.0371573187987575,FALSE
+"H3255","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.38963,-1.19,0.239,8086,0.708,"PAK2, PIP4K2B, MSN, ARHGEF7, PAK3, F2, F2R, SOS1, PIK3CB, ARHGEF6, RAC2, DIAPH1, VCL, BCAR1, NCKAP1, BAIAP2, CYFIP1, DOCK1, CD14, MAP2K1, CSK, RAF1, DIAPH3, ARAF, ITGB3, RDX, MYLK, WAS, ITGB1, PIP5K1A, ITGA5, MOS, DIAPH2, ITGB8, ITGA6, FGF13, FGF2, ARHGEF4",0.621602099051862,0.149966742310231,FALSE
+"H3255","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.41874,-1.24,0.205,7595,0.663,"BECN1, GABARAPL1, PIK3C3, ATG3, GABARAPL2, ATG7",0.688246138944246,0.178486471595227,FALSE
+"H3255","Input","KEGG_RENAL_CELL_CARCINOMA",-0.27462,-0.837,0.631,7685,0.837,"CUL2, RAP1B, RAPGEF1, PTPN11, PAK2, PAK3, VHL, HGF, SOS1, PIK3CB, MAP2K1, RAF1, SLC2A1, EGLN1, ARAF, ETS1, TGFB2",0.199970640755866,0.07727454200674,FALSE
+"H3255","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.64205,-1.98,0.00975,9597,1,"ANPEP, CPA3, ACE",2.01099538430146,0,FALSE
+"H3255","Input","KEGG_RETINOL_METABOLISM",0.27614,0.861,0.609,1532,0.891,"RDH11, DHRS3, DHRS4, CYP3A4",0.215382707367125,0.0501222959631252,FALSE
+"H3255","Input","KEGG_RIBOFLAVIN_METABOLISM",0.6086,1.86,0.0252,904,0.227,"ENPP3, ACP2, ACP5",1.59859945921846,0.643974142806877,TRUE
+"H3255","Input","KEGG_RIBOSOME",-0.59276,-1.78,0.0329,6387,0.763,"RPL37A, RPS4X, FAU, RPL24, RSL24D1, RPL23, RPS5, RPS19, RPL27, RPS15, RPL3, RPL21, RPS17, RPL29, RPL15, RPL23A, RPS8, RPL35, RPS3A, RPL30, RPS13, RPL35A, RPL8, RPL27A, RPL5, RPL32, RPS3, RPL18, RPL36A, RPL36AL, RPS9, RPL18A, RPS15A, RPS25, RPS7, RPL26, RPL38, RPL28, RPL6, RPS24, RPL22, RPL34, RPL17, RPS2, RPL11, RPL9, RPS18, RPL13A, RPL4, RPL31, RPS16, RPS29, RPS20, RPL19, RPL10A, RPS6, RPL14, RPS11, RPL37, RPL7A, RPS23, RPL7, UBA52, RPL36, RPS27L, RPS4Y1",1.48280410205003,0.11747546204512,FALSE
+"H3255","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21217,0.653,0.927,741,0.952,"MAPK12, IRF7, MAPK13, DDX58, CASP10",0.0329202658555029,0.0213630516155257,FALSE
+"H3255","Input","KEGG_RNA_DEGRADATION",-0.35406,-1.1,0.321,6817,0.797,"CNOT4, CNOT9, PARN, DCP1A, CNOT7, EXOSC5, CNOT2, PAPOLG, EXOSC10, CNOT1, EXOSC3, DDX6, MTREX, ENO3, XRN1, CNOT6L, PATL1, EDC3, MPHOSPH6, CNOT6, DIS3, DCPS, C1D",0.493494967595128,0.0985416786038876,FALSE
+"H3255","Input","KEGG_RNA_POLYMERASE",-0.19527,-0.583,0.96,1932,1,"POLR2J, POLR3GL, POLR1E, POLR3G, POLR2D, POLR2G, POLR2I, POLR2F, POLR2E, POLR2C, POLR2K, POLR2L, POLR2H, POLR1B, POLR1A, POLR2A, POLR3C, POLR1C, POLR1D, POLR2B, POLR3D, POLR3F, POLR3K, POLR3H, POLR3A, POLR3B",0.0177287669604316,0,FALSE
+"H3255","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.43698,1.32,0.149,1288,0.552,"GGT5, GGT1, PAPSS2, TRMT11, CTH",0.826813731587726,0.258060922270801,FALSE
+"H3255","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.34335,-1.05,0.37,9225,0.827,"BIRC2, ITGB1, LAMA3, LAMA4, COL4A1, COL4A6, ITGA6, COL4A2, TP53",0.431798275933005,0.0824944904474534,FALSE
+"H3255","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.41183,1.25,0.185,1992,0.556,"VTI1B, GOSR2, STX16, STX8, BET1L, GOSR1, STX17, VAMP4, STX6, VAMP8, TSNARE1",0.732828271596986,0.254925208417942,FALSE
+"H3255","Input","KEGG_SPHINGOLIPID_METABOLISM",0.48964,1.53,0.0807,908,0.39,"GALC, NEU1, ASAH1, ARSA, SMPD1, SGPP1, PLPP1, PLPP2",1.09312646527793,0.408935392973501,FALSE
+"H3255","Input","KEGG_SPLICEOSOME",0.32927,1.04,0.38,3991,0.701,"HSPA6, ISY1, SRSF9, SF3B5, NCBP2, DDX42, DDX23, SRSF5, PRPF19, PRPF40A, SF3A1, TRA2A, SNRPG, PQBP1, HSPA1A, BCAS2, LSM2, PPIL1, HNRNPA1, CDC5L, SRSF8, SNRPB2, CDC40, SYF2, PPIE, PHF5A, PLRG1, SART1, WBP11, U2AF1, SRSF2, SRSF4, CCDC12, SNRNP200, LSM8, ACIN1, TRA2B, SNRPF, SRSF3, SNW1, HNRNPA3, SRSF1, TXNL4A, SRSF7, HSPA1L, SNRNP40, RBM8A, RBMX, PRPF6, HNRNPM, SNRPB, DDX5, EFTUD2, SF3B2, U2AF2, THOC3, RBM17, LSM7, HNRNPK, SNRPA1, SF3B3, XAB2, LSM6, SF3A3",0.42021640338319,0.154281982033341,FALSE
+"H3255","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.4374,1.35,0.13,258,0.586,"ENPP3, GUSB",0.886056647693163,0.232102383981909,FALSE
+"H3255","Input","KEGG_STEROID_BIOSYNTHESIS",0.63439,1.91,0.0164,2032,0.319,"DHCR24, DHCR7, LSS, TM7SF2, FDFT1, CYP27B1, CYP51A1, SOAT2, MSMO1, SC5D",1.7851561519523,0.496209316942819,FALSE
+"H3255","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.49854,1.57,0.0497,1835,0.397,"SULT2B1, AKR1D1, SRD5A3, HSD11B2, STS, HSD17B12, COMT, AKR1C3, HSD17B8, CYP3A4, AKR1C1",1.30364361126667,0.401209493236885,FALSE
+"H3255","Input","KEGG_SULFUR_METABOLISM",0.53852,1.62,0.0728,707,0.365,"SULT2B1, SUOX, PAPSS2",1.13786862068696,0.437707135543525,FALSE
+"H3255","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.57395,-1.74,0.0302,9353,0.511,"C1S, TRIM21, C3, CD40",1.51999305704285,0.291579099865287,FALSE
+"H3255","Input","KEGG_TASTE_TRANSDUCTION",0.26359,0.798,0.693,3980,0.909,"ITPR3, GNB3, GNAS, ADCY6, PRKACA, CACNA1A",0.159266765388193,0.0414361167780325,FALSE
+"H3255","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.42654,1.33,0.133,1331,0.561,"PDSS2, HMGCS1, HMGCR, ACAT2",0.876148359032914,0.251037138743839,FALSE
+"H3255","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.28957,-0.865,0.621,6712,0.811,"SMAD1, E2F4, SKP1, SMAD5, SMAD4, TGFBR1, AMH, MAPK3, MYC, SMAD2, CUL1, BMPR2, SP1, ID1, INHBA, PPP2R1B, SMAD9, TFDP1, BMPR1A, TGFB2",0.20690839982342,0.090979145788844,FALSE
+"H3255","Input","KEGG_THYROID_CANCER",-0.34566,-1.04,0.379,8378,0.817,"PPARG, TFG, PAX8, MAP2K1, LEF1, TP53",0.421360790031928,0.0877779434675845,FALSE
+"H3255","Input","KEGG_TIGHT_JUNCTION",0.24142,0.734,0.793,2180,0.928,"CLDN3, PATJ, CRB3, EPB41L3, PRKCH, AFDN, CTNNB1, CGN, OCLN, CLDN4, TJP3, MYH2, MPDZ, MAGI3, PARD6A, MYH7, MYH3, CTNNA1, TJP2, HRAS, PRKCI, PARD6G, AKT1",0.100726812682396,0.0324520237811379,FALSE
+"H3255","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.25273,0.772,0.745,558,0.916,"LY96, MYD88, MAPK12, TLR2, IRF7, TOLLIP, MAPK13",0.127843727251707,0.0381045263321496,FALSE
+"H3255","Input","KEGG_TRYPTOPHAN_METABOLISM",0.31548,0.972,0.474,1824,0.759,"ALDH2, GCDH, ALDH3A2, MAOA, OGDHL, ACAT2, OGDH, EHHADH",0.324221658325915,0.11975822410452,FALSE
+"H3255","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.50204,-1.51,0.0744,9126,0.699,"PKM, MAPK8, PKLR, MAPK10, SOCS4, IRS2",1.12842706445412,0.155522824254319,FALSE
+"H3255","Input","KEGG_TYROSINE_METABOLISM",-0.43489,-1.33,0.154,6964,0.736,"MIF, TAT, ADH5, ADH1C, METTL2B, GOT2, DCT, LCMT1, MAOB, ALDH3B1, ALDH1A3, HGD, LCMT2, ALDH3A1",0.812479279163537,0.133122185662501,FALSE
+"H3255","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.28586,-0.865,0.598,8086,0.811,"PAK2, PAK3, FYN, CBLB, NCK1, SOS1, PIK3CB, LAT, PPP3CC, LCK, NCK2, MAP2K7, BCL10, MAP2K1, RAF1, NFATC1, CARD11, MALT1, PRKCQ, NFAT5, CBL",0.223298816011589,0.090979145788844,FALSE
+"H3255","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.27742,-0.831,0.639,7165,0.839,"SIAH1, UBE2K, NEDD4, UBE2M, UBE2B, RNF7, UBA3, MID1, CUL2, CUL1, COP1, HERC3, XIAP, UBE4B, UBE4A, KEAP1, CBLB, CUL4A, VHL, WWP1, UBE2F, CDC26, UBE2Q1, UBE2E2, UBA1, UBE2D2, CUL4B, CUL5, HUWE1, BIRC2, PML, HERC4, UBE2E1, UBA7, CBL, FBXO2",0.1944991418416,0.0762380391712997,FALSE
+"H3255","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.27274,-0.825,0.661,5944,0.81,"PDHB, VARS2, PDHA1, LARS2",0.17979854051436,0.0915149811213502,FALSE
+"H3255","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.5036,1.55,0.0818,1996,0.393,"ACAD8, OXCT1, ALDH2, ALDH6A1, HMGCS1, ACAA1, IVD, BCKDHA, ALDH3A2, HIBADH, BCKDHB, ACAT2, BCAT2, ACADSB, EHHADH, HIBCH, PCCA",1.08724669632868,0.405607449624573,FALSE
+"H3255","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.28456,-0.863,0.604,8757,0.805,"PLCB4, MAP2K1, RAF1, ARAF, MYLK, CACNA1F, PRKCQ, CALD1, PLA2G6",0.218963061378868,0.0942041196321315,FALSE
+"H3255","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.1831,-0.556,0.988,6922,1,"DYNLL2, DYNC1LI1, ADCY3, DYNC1H1, VAMP2, ADCY9, DCTN5, DYNC2LI1, DCTN2, STX4, RAB11A, DCTN4, DCTN1, CREB5",0.00524305541237188,0,FALSE
+"H3255","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23102,0.715,0.854,1254,0.933,"PTGS2, PLA2G4A, MAPK12, MAPK13, PLA2G12A, VEGFA, PPP3R1, BAD",0.068542129310995,0.0301183562535,FALSE
+"H3255","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.22932,0.71,0.832,3387,0.927,"PDIA4, ERO1A, KDELR1, SLC12A2, ATP6V1F, TJP2, ATP6AP1, GNAS, TJP1, ATP6V1G1, ATP6V1B1, ATP6V1E1, ATP6V1B2, ATP6V0A1, ACTB",0.0798766737092761,0.0329202658555029,FALSE
+"H3255","Input","KEGG_VIRAL_MYOCARDITIS",0.22327,0.672,0.902,499,0.941,"ICAM1, CCND1, CD55",0.0447934624580583,0.0264103765727431,FALSE
+"H3255","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.3,-0.914,0.525,7165,0.873,"SIAH1, CSNK2A1, CSNK2A2, MYC, CHP1, PPP2R5A, NFATC3, SMAD2, PLCB2, RAC3, CUL1, CACYBP, VANGL1, PPP2R5D, AXIN2, FZD2, PPP3CC, PORCN, RAC2, PLCB4, NLK, PPP2R1B, MMP7, NFATC1, CSNK1E, MAPK8, LEF1, MAPK10, SOX17, FZD7, WNT10A, FOSL1, NFAT5, WNT7A, TP53",0.279840696594043,0.0589857562944303,FALSE
+"H358","Input","KEGG_ABC_TRANSPORTERS",-0.6212,-1.92,0.0154,7484,0.208,"ABCB4, ABCB7, ABCB6, ABCC5, ABCA1, ABCD1, ABCC3, ABCC6, ABCB1, ABCA3, ABCB10, ABCB8, ABCC2, ABCB11",1.81247927916354,0.681936665037238,TRUE
+"H358","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.22332,0.69,0.884,1293,0.894,"PIK3R3, PIK3CD, RPS6KB2, RUNX1, CCND1, KRAS, NRAS, RPS6KB1, PIK3CA",0.0535477349869269,0.0486624812040823,FALSE
+"H358","Input","KEGG_ADHERENS_JUNCTION",0.44542,1.36,0.13,1897,0.636,"RAC2, CDH1, CTNNA1, CTNND1, CTNNB1, CTNNA2, BAIAP2, LMO7, PTPRF, NECTIN4, ERBB2, SMAD3, RAC3, FARP2, MET, CSNK2A1, CSNK2A2, TJP1, PTPRJ, IGF1R, EP300, CREBBP, CSNK2B, ACTN4, NECTIN3, CDC42, YES1, PTPRB",0.886056647693163,0.196542884351586,FALSE
+"H358","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.37773,1.2,0.207,940,0.507,"IRS1, SLC2A1, RXRA, MAPK10, MAPK9, RXRG, ADIPOR1, RXRB",0.684029654543082,0.294992040666664,FALSE
+"H358","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.64866,-1.96,0.00949,8106,0.236,"ASNS, GPT, AGXT, ALDH5A1, GLS, GLS2, CPS1, GOT1, ALDH4A1, ASS1, ABAT, NIT2",2.02273378757271,0.627087997029893,TRUE
+"H358","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.43781,1.33,0.143,409,0.625,"IRS1, SLC9A3R2, PIK3R3, SCNN1B, ATP1B1, PIK3CD",0.844663962534938,0.204119982655925,FALSE
+"H358","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.6165,1.86,0.0278,974,0.551,"PLA2G4A, PLA2G12A",1.55595520408192,0.258848401148215,FALSE
+"H358","Input","KEGG_ALZHEIMERS_DISEASE",-0.30126,-0.918,0.51,6143,0.688,"MAPK3, ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ERN1, LRP1, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, GRIN1, NDUFA10, ATP5F1D, GNAQ, COX7A2L, GSK3B, NDUFA7, NDUFB2, COX6B1, MAPK1, ATP5F1B, CASP9, NDUFS6, NDUFV2, BID, ATP5PD, NDUFS3, ITPR3, APOE, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, GAPDH, APAF1, NDUFA5, UQCRC1, CDK5, PPP3CC, ATP5MC2, UQCRFS1, IDE, ITPR1, UQCRC2, ITPR2, SNCA, MAPT",0.292429823902064,0.162411561764489,FALSE
+"H358","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.3828,-1.18,0.26,5801,0.406,"FARSA, NARS2, VARS2, FARSB, AARS2, TARS2, DARS2, CARS2, EARS2, RARS2",0.585026652029182,0.391473966422806,FALSE
+"H358","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.45595,-1.37,0.112,6602,0.32,"UGP2, NAGK, GMPPA, GCK, MPI, GNE, GFPT1, HEXA, CYB5R3, NANS, PMM1, GNPDA1, GPI, UAP1, CYB5R1, RENBP, GALK1, CMAS, UXS1, PGM3, HEXB",0.950781977329818,0.494850021680094,FALSE
+"H358","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.43894,-1.37,0.122,7699,0.32,"CYCS, APAF1, CASP1, CAT, MAPK12, MAPK11, BAX, CCS, PPP3CC, SOD1, NEFL, NEFM, TP53, PRPH, PRPH2, NEFH",0.913640169325252,0.494850021680094,FALSE
+"H358","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.19338,0.598,0.972,2816,0.975,"PSME1, PSME2, B2M, HSPA2, PSME3, NFYC, NFYB, CREB1, HSPA1A, HSP90AB1, TAPBP, HSP90AA1, TAP1",0.0123337350737254,0.0109953843014632,FALSE
+"H358","Input","KEGG_APOPTOSIS",0.24267,0.744,0.795,1584,0.835,"PIK3R3, TNFRSF10A, PIK3CD, CAPN2, PPP3CA, CASP6, PPP3R2, ENDOD1, PPP3R1, ENDOG, PIK3CA, FAS, CHP1, CAPN1, BAD",0.0996328713435297,0.0783135245163979,FALSE
+"H358","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.38862,-1.18,0.242,7465,0.406,"GPX4, TBXAS1, GGT7, GGT1, GPX2, CBR3, CBR1, GPX6, GPX7, AKR1C3, ALOX5",0.616184634019569,0.391473966422806,FALSE
+"H358","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.43376,-1.31,0.136,8508,0.327,"AGMAT, GLS, GLS2, CPS1, CKMT2, GOT1, SAT1, ALDH4A1, MAOB, ASS1, ALDH2, ARG2, CKMT1A",0.866461091629782,0.485452247339714,FALSE
+"H358","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.30731,0.961,0.462,1649,0.706,"ITGB6, ITGB4, ITGA3, CTNNA1, LMNA, CTNNB1, CTNNA2, DSC2, DAG1, ITGB5, ITGA6, ATP2A2, DMD, DSG2, ITGA2, ACTN4",0.335358024443874,0.151195298948196,FALSE
+"H358","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.37767,-1.16,0.257,7819,0.427,"ALDH7A1, ALDH2",0.590066876668705,0.369572124974976,FALSE
+"H358","Input","KEGG_AXON_GUIDANCE",0.41139,1.25,0.202,1123,0.475,"RAC2, EPHA2, SEMA7A, EPHB2, SEMA3A, EPHA6, SEMA4B, EPHA1, RASA1, EPHB3, PPP3CA, EPHA5, EPHA4, SEMA4C, RAC3, NRP1, NGEF, PPP3R2, MET, KRAS, NRAS, EFNB2, PPP3R1",0.694648630553376,0.323306390375133,FALSE
+"H358","Input","KEGG_BASAL_CELL_CARCINOMA",-0.49233,-1.5,0.0758,6906,0.267,"GSK3B, FZD7, FZD1, DVL3, DVL2, STK36, TCF7L2, LEF1, WNT16, TP53, WNT11",1.12033079436795,0.573488738635425,FALSE
+"H358","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.32691,0.958,0.433,3472,0.698,"GTF2E2, TAF9B, GTF2B, TAF6L, TAF1, GTF2E1, GTF2IRD1, GTF2I, TAF5L, TAF5, GTF2F1, TAF6, TAF4, TAF2, GTF2A1",0.363512103646635,0.156144577376839,FALSE
+"H358","Input","KEGG_BASE_EXCISION_REPAIR",0.59343,1.81,0.022,2035,0.405,"TDG, PCNA, POLD3, PARP2, NEIL2, UNG, FEN1, POLD1, LIG1, POLE3, MUTYH, APEX1, POLD2, APEX2, POLE2, POLB",1.65757731917779,0.392544976785331,FALSE
+"H358","Input","KEGG_BETA_ALANINE_METABOLISM",-0.58564,-1.8,0.0235,6587,0.175,"SRM, ECHS1, ALDH1B1, ACADM, DPYD, MLYCD, ALDH7A1, EHHADH, ALDH2, ABAT",1.62893213772826,0.756961951313706,TRUE
+"H358","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29329,0.901,0.553,1225,0.748,"HACD1, ELOVL5, ELOVL6, FADS1",0.257274868695302,0.126098402135539,FALSE
+"H358","Input","KEGG_BLADDER_CANCER",0.36401,1.12,0.302,1089,0.504,"CDH1, THBS1, RB1, CCND1, ERBB2, KRAS, NRAS",0.519993057042849,0.297569463554475,FALSE
+"H358","Input","KEGG_BUTANOATE_METABOLISM",-0.51511,-1.56,0.0596,7819,0.232,"ALDH7A1, ACADS, HMGCS1, AKR1B10, ACAT2, ALDH5A1, EHHADH, HMGCS2, ALDH2, ABAT",1.22475374025976,0.6345120151091,FALSE
+"H358","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31463,0.977,0.426,1362,0.687,"RAC2, PIK3R3, LYN, PIK3CD, PPP3CA, RAC3, PPP3R2, KRAS, NRAS, PPP3R1, PIK3CA, CHP1",0.370590400897281,0.16304326294045,FALSE
+"H358","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2962,0.92,0.483,1857,0.764,"TNNC1, TNNC2, LTB4R2, PPP3CA, ERBB2, PLCB1, PTK2B, MYLK, PPP3R2, HRH1, CAMK2D, CACNA1A, PPP3R1, CAMK2G, CHP1, ERBB3, PRKCG, ATP2A2, ERBB4, PHKB, PPP3CB, ATP2B1, PHKA1",0.316052869248488,0.11690664142431,FALSE
+"H358","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.29258,0.901,0.512,1505,0.748,"TNNC1, ATP1B1, SLC9A6, CYC1, SLC9A1, MYL3, UQCR10, ATP2A2",0.290730039024169,0.126098402135539,FALSE
+"H358","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.46036,1.43,0.106,602,0.67,"CLDN7, CDH15, CDH3, ITGB2, CLDN4, SDC4, SDC1, CDH1, CD274, F11R, CNTN1, CLDN3, PTPRF, CD276, SDC2",0.97469413473523,0.173925197299174,FALSE
+"H358","Input","KEGG_CELL_CYCLE",0.4905,1.46,0.107,1942,0.661,"FZR1, CDC20, CCNA2, MCM4, MCM7, ORC6, CHEK1, MCM5, MCM6, MCM3, BUB1, PCNA, CCNB1, RB1, PLK1, CCND1, CCNB2, SMAD3, MAD2L1, MCM2, SKP2, RBL1, BUB1B, TGFB2, CDC45, CDK1, CDK2, YWHAZ, CDC7, EP300, STAG2, CREBBP, RAD21, SMC3, SFN, CDC6, ESPL1, TTK, TFDP1, SMC1A, BUB3, ORC4, RBX1, PRKDC, YWHAQ, SMC1B",0.97061622231479,0.17979854051436,FALSE
+"H358","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.26252,0.804,0.704,1326,0.796,"RAC2, PIK3R3, HCK, LYN, PIK3CD, GNG10, GRK2, PLCB1, PTK2B, GNG5, KRAS, NRAS, PRKCD, BCAR1, PIK3CA, PRKCZ",0.152427340857888,0.0990869322623309,FALSE
+"H358","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.22527,-0.688,0.883,8017,0.94,"PIK3R1, CRKL, TGFB1, TGFB3, MAP2K2, CDKN2A, PIK3CB, CDKN1B, CRK, SOS1, TP53",0.0540392964224314,0.0268721464003014,FALSE
+"H358","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.40871,-1.24,0.196,7527,0.351,"OGDH, PC, IDH1, OGDHL, ACO2, IDH2, PCK2",0.707743928643524,0.454692883534176,FALSE
+"H358","Input","KEGG_COLORECTAL_CANCER",0.36981,1.15,0.244,1702,0.493,"RAC2, PIK3R3, CTNNB1, PIK3CD, MAPK10, MAPK9, CCND1, MSH6, SMAD3, MSH2, RAC3, TGFB2, KRAS, PIK3CA, MLH1, BAD, MSH3",0.612610173661271,0.30715308072277,FALSE
+"H358","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.45796,-1.4,0.105,7947,0.343,"CFD, C3, FGB, PROS1, SERPIND1, SERPINE1, THBD, C5, F5, SERPINA1, C4A, SERPINF2, C9, SERPING1, A2M, PLG",0.978810700930062,0.464705879957229,FALSE
+"H358","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.19193,-0.59,0.978,6360,0.978,"MAT2B, MTR, SRM, MTAP, SDS, APIP, MPST, ADI1, GOT1, CDO1",0.00966114521239857,0.00966114521239857,FALSE
+"H358","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.35815,-1.09,0.335,7654,0.49,"IFNGR1, KIT, LEPR, IL17RA, CSF2RA, TGFB1, OSM, TGFB3, CD70, IL25, HGF, NGFR, IFNAR2, INHBE, IL6",0.474955192963155,0.309803919971486,FALSE
+"H358","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.32932,-0.996,0.417,9147,0.582,"ZBP1, PYCARD, IL6",0.379863945026242,0.235077015350112,FALSE
+"H358","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.31951,-0.976,0.46,8449,0.608,"SGCB, TGFB3, ITGB8, TPM2, ITGB3, ACTG1, SGCD, ITGA5, ITGA7, DES, ITGA4",0.337242168318426,0.216096420727265,FALSE
+"H358","Input","KEGG_DNA_REPLICATION",0.71474,2.24,0.00218,1339,0.264,"MCM4, MCM7, POLA1, PRIM1, MCM5, MCM6, MCM3, PRIM2, PCNA, POLD3, RFC3, FEN1, POLD1, LIG1, MCM2, RFC4, POLA2, RFC5, POLE3, RFC2, RNASEH2A, DNA2, RNASEH2B, POLD2",2.6615435063954,0.578396073130169,FALSE
+"H358","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.41391,1.3,0.152,1088,0.519,"NOTCH3, ETS1, KRAS",0.818156412055227,0.284832642151542,FALSE
+"H358","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.44433,-1.37,0.124,8249,0.32,"GSTO1, CYP3A5, MGST3, GSTK1, MAOB, GSTM3, GSTM1, GSTM2, GSTM4",0.906578314837765,0.494850021680094,FALSE
+"H358","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.29305,-0.898,0.558,8083,0.706,"GUSB, CYP3A5, CES1, CES2, UMPS, TPMT, NAT2",0.253365801062421,0.151195298948196,FALSE
+"H358","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.37486,1.17,0.248,273,0.513,"ITGB6, LAMC2, TNC, ITGB4, SDC4, SDC1, ITGA3, LAMB3, LAMA5, AGRN, THBS1",0.605548319173784,0.289882634888184,FALSE
+"H358","Input","KEGG_ENDOCYTOSIS",-0.2565,-0.792,0.719,6243,0.834,"AP2M1, SH3GL1, RNF41, IQSEC1, ACAP3, CHMP4A, CHMP4B, CLTB, RAB4A, PDCD6IP, EPN1, RAB5B, RBSN, SRC, AP2S1, PIP4K2B, RAB11FIP5, CBLB, EHD3, VPS36, STAM2, VTA1, PARD6G, VPS37C, HGS, PARD3, ARRB1, ASAP3, VPS4B, EPS15, PIP5K1C, CHMP3, PARD6B, DAB2, ARFGAP2, TRAF6, KIT, EEA1, PIKFYVE, ACAP2, VPS25, FGFR3, PRKCI, FGFR4, SNF8, ARFGAP1, ARFGAP3, CHMP5, DNM1L, ARRB2, ASAP2, DNM2, PLD1, GIT2, AP2A2, RABEP1, VPS37A, STAM, SH3GL2",0.143271109617117,0.0788339493622613,FALSE
+"H358","Input","KEGG_ENDOMETRIAL_CANCER",0.34581,1.04,0.36,1584,0.617,"CDH1, CTNNA1, PIK3R3, CTNNB1, CTNNA2, PIK3CD, CCND1, ERBB2, PTEN, KRAS, NRAS, PIK3CA, MLH1, BAD",0.443697499232713,0.209714835966758,FALSE
+"H358","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23559,0.746,0.793,981,0.843,"MAPK13, F11R, LYN, MAPK10, MAPK9, MET, TJP1",0.100726812682396,0.0741724253752577,FALSE
+"H358","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.38844,1.19,0.227,1584,0.495,"EREG, AREG, PIK3R3, PIK3CD, MAPK10, RPS6KB2, MAPK9, ERBB2, CAMK2D, KRAS, NRAS, RPS6KB1, MAP2K4, CAMK2G, PIK3CA, ERBB3, PRKCG, ERBB4, BAD",0.643974142806877,0.305394801066431,FALSE
+"H358","Input","KEGG_ETHER_LIPID_METABOLISM",0.48928,1.49,0.0794,974,0.728,"LPCAT2, LPCAT4, PLPP2, LPCAT1, PLA2G4A, PLA2G12A",1.1001794975729,0.137868620686963,FALSE
+"H358","Input","KEGG_FATTY_ACID_METABOLISM",-0.40144,-1.24,0.206,7739,0.351,"ECI2, ALDH7A1, ACADS, ACAT2, ACSL5, EHHADH, GCDH, ALDH2, ACADSB, ACAA2",0.686132779630847,0.454692883534176,FALSE
+"H358","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.44116,1.39,0.102,1293,0.707,"MAPK13, RAC2, PIK3R3, LYN, PIK3CD, MAPK10, MAPK9, PLA2G4A, RAC3, PLA2G12A, KRAS, NRAS, PRKCD, MAP2K4, PIK3CA",0.991399828238082,0.150580586203101,FALSE
+"H358","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.27061,0.83,0.637,685,0.794,"RAC2, PIK3R3, HCK, LYN, PLPP2, PIK3CD, RPS6KB2, PLA2G4A, MARCKSL1, SCIN",0.19586056766465,0.100179497572904,FALSE
+"H358","Input","KEGG_FOCAL_ADHESION",0.27438,0.851,0.612,663,0.763,"RAC2, ITGB6, LAMC2, TNC, ITGB4, CAV1, ITGA3, CAV2, LAMB3, LAMA5, THBS1, PIK3R3, CTNNB1, PIK3CD, MAPK10, MAPK9, CAPN2, CCND1, ERBB2, PTEN",0.213248577854439,0.11747546204512,FALSE
+"H358","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.56123,-1.71,0.0408,7518,0.186,"ALPG, QDPR, SPR, GGH",1.38933983691012,0.730487055782084,TRUE
+"H358","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.26697,-0.823,0.661,6206,0.795,"PMM2, PFKP, TPI1, GMPPA, PFKM, MPI, PMM1, PFKL, MTMR6, AKR1B10, PHPT1, AKR1B1",0.17979854051436,0.0996328713435297,FALSE
+"H358","Input","KEGG_GALACTOSE_METABOLISM",-0.27798,-0.88,0.559,5799,0.731,"GALT, GLA, GANC, PFKP, UGP2, GLB1, GCK, PFKM, PFKL, GALK1, AKR1B1",0.252588192113577,0.13608262304214,FALSE
+"H358","Input","KEGG_GAP_JUNCTION",-0.29563,-0.945,0.516,6333,0.646,"PRKACB, GUCY1B1, GNA11, TUBA1C, TUBA1B, TUBB1, GNAI1, RAF1, TUBB, TUBA3C, SRC, GNAQ, TUBB2A, MAPK7, MAPK1, ITPR3, GRM5, TUBB6, GUCY1A1, TUBB2B, MAP2K2, GJA1, ITPR1, TUBB4A, ITPR2, SOS1",0.287350298372789,0.189767482004916,FALSE
+"H358","Input","KEGG_GLIOMA",0.28779,0.882,0.544,1461,0.737,"PIK3R3, PIK3CD, RB1, CCND1, PTEN, CAMK2D, KRAS, NRAS, IGF1R, CAMK2G, PIK3CA, PRKCG",0.26440110030182,0.132532512140949,FALSE
+"H358","Input","KEGG_GLUTATHIONE_METABOLISM",-0.53235,-1.69,0.0272,7465,0.191,"GPX4, GGT7, GSTP1, GSTA4, GGCT, IDH1, GGT1, GPX2, GSTO1, RRM2B, MGST3, ANPEP, IDH2, GPX6, GPX7, GSTK1, TXNDC12, GSTM3, GSTM1, GSTM2, GSTM4",1.5654310959658,0.718966632752272,TRUE
+"H358","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.33778,-1.04,0.36,8822,0.533,"PLPP1, GK, AKR1B1, AKR1A1, ALDH2, AGPAT3",0.443697499232713,0.273272790973428,FALSE
+"H358","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32143,0.982,0.413,554,0.691,"LPCAT2, LPCAT4, MBOAT2, PLPP2, LPCAT1, CHKB, MBOAT1, PLA2G4A, GPAT3",0.384049948343599,0.160521952625802,FALSE
+"H358","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.45088,-1.39,0.114,8322,0.334,"AGXT, PSPH, GCAT, SARDH, PSAT1, MAOB, GLDC",0.943095148663527,0.476253533188435,FALSE
+"H358","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.23074,0.724,0.828,1568,0.855,"ALDH1A3, ADH4, ADH7, PKM, PGM2, PKLR, ENO1, ENO3, ALDH3A2, ALDH3B1",0.0819696632151199,0.0680338852718274,FALSE
+"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.56934,-1.74,0.0286,7600,0.184,"XYLT2, CHST13, CSGALNACT2, CHST12, B4GALT7, XYLT1, CHST3, CHST11",1.54363396687096,0.735182176990464,TRUE
+"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35211,-1.09,0.33,7600,0.49,"XYLT2, NDST1, EXTL2, B4GALT7, XYLT1",0.481486060122112,0.309803919971486,FALSE
+"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.43658,-1.32,0.153,8711,0.331,"B4GALT4, ST3GAL1",0.815308569182401,0.480172006224281,FALSE
+"H358","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.36731,-1.15,0.263,8073,0.433,"HGSNAT, GUSB, IDUA, GNS, HEXB, ARSB",0.580044251510242,0.363512103646635,FALSE
+"H358","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.68557,-2.09,0.00202,8603,0.151,"NAGA, HEXB, ST3GAL1",2.69464863055338,0.821023052706831,TRUE
+"H358","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.47613,-1.46,0.102,8711,0.288,"B4GALT4, FUT4, ST3GAL6",0.991399828238082,0.540607512240769,FALSE
+"H358","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.37327,1.15,0.248,1236,0.493,"PIGG, PIGW, PIGK, PIGS, PIGT",0.605548319173784,0.30715308072277,FALSE
+"H358","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.43064,-1.34,0.123,8167,0.331,"GRHPR, ACO2, PGP",0.910094888560602,0.480172006224281,FALSE
+"H358","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28301,0.884,0.536,1216,0.745,"MAPK13, MAPK10, MAPK9, PLA2G4A, PLCB1, PTK2B, PLA2G12A, CAMK2D, KRAS, NRAS, PRKCD, MAP2K4, CAMK2G",0.27083521030723,0.127843727251707,FALSE
+"H358","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.33321,-1.03,0.395,8928,0.533,"WNT16, WNT11",0.40340290437354,0.273272790973428,FALSE
+"H358","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.41356,-1.26,0.176,7735,0.341,"KIT, ITGA1, CSF2RA, ANPEP, ITGB3, CD7, ITGA5, ITGA4, IL6",0.75448733218585,0.467245621007502,FALSE
+"H358","Input","KEGG_HISTIDINE_METABOLISM",-0.34815,-1.07,0.345,7312,0.515,"TRMT11, AOC1, ALDH7A1, HNMT, LCMT1, MAOB, DDC, ALDH2",0.462180904926726,0.288192770958809,FALSE
+"H358","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.41437,1.26,0.176,2231,0.49,"POLD3, RAD54B, POLD1, RAD51C, EME1, RAD54L, POLD2, RPA3, BLM, RPA2, TOP3A, RPA1",0.75448733218585,0.309803919971486,FALSE
+"H358","Input","KEGG_HUNTINGTONS_DISEASE",-0.33169,-1.03,0.386,6162,0.533,"ATP5PO, NDUFS7, NDUFB6, TFAM, ATP5PF, NDUFV1, AP2M1, COX6A1, NDUFS2, CLTB, NDUFB10, CREB5, ATP5F1E, NDUFV3, DNAL1, NDUFA8, NDUFS4, ATP5PB, GRIN1, NDUFA10, VDAC2, ATP5F1D, AP2S1, CREB3L2, GNAQ, COX7A2L, NDUFA7, NDUFB2, COX6B1, VDAC1, ATP5F1B, CASP9, POLR2I, DCTN4, NDUFS6, NDUFV2, ATP5PD, NDUFS3, IFT57, DNAH2, GRM5, TGM2, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, APAF1, NDUFA5, HIP1, UQCRC1, DCTN1, BAX, AP2A2, ATP5MC2, UQCRFS1, SOD1, DCTN2, ITPR1, UQCRC2, SOD2, TP53",0.413412695328245,0.273272790973428,FALSE
+"H358","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34436,-1.06,0.355,7794,0.523,"PRKAB2, ITGA1, CACNA2D2, ACE, TGFB1, SGCB, TGFB3, ITGB8, TPM2, ITGB3, ACTG1, SGCD, ITGA5, ITGA7, DES, ITGA4, IL6",0.449771646944906,0.281498311132726,FALSE
+"H358","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.27896,-0.864,0.579,6782,0.744,"PIP4K2A, PIP4K2B, PIK3C2A, SYNJ1, PIK3C2B, OCRL, PIP5K1C, PLCG1, PIK3C3, INPP5K, PIKFYVE, PLCG2, ITPKA, IMPA1, MINPP1, ITPK1, PIK3CB, ITPKB",0.237321436272564,0.128427064454121,FALSE
+"H358","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.19998,-0.623,0.949,6207,0.965,"RPTOR, TSC2, PRKAA1, PRKAR2A, MAPK8, PRKACB, PRKAA2, FLOT2, AKT3, PRKAG2, RAF1, PRKAR1A, GCK, CBLB, GSK3B, PIK3R2, RAPGEF1, MAPK1, RHEB, SHC1, PRKAG1, PPP1R3D, TSC1, PRKAR1B, GYS1, INPP5D, PRKAR2B, PRKAB2, IRS2, INPP5K, PIK3R1, PRKCI, PPP1R3A, CRKL, INSR, MAP2K2, PIK3CB, PDE3B, CRK, SORBS1, PCK2, FOXO1, SOS1",0.0227337875727074,0.0154726866562074,FALSE
+"H358","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.68318,-2.1,0.00723,8209,0.186,"ICOSLG, TGFB1, ITGA4, IL6",2.14086170270547,0.730487055782084,TRUE
+"H358","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.27411,-0.851,0.616,7649,0.75,"TYK2, IFNGR1, LEPR, STAT5A, PIK3R1, CSF2RA, OSM, PIM1, STAT2, STAM, PIK3CB, PIAS2, SOS1, IFNAR2, IL6",0.210419287835575,0.1249387366083,FALSE
+"H358","Input","KEGG_LEISHMANIA_INFECTION",0.37631,1.16,0.267,52,0.516,"MAPK13, ITGB2, PTGS2",0.573488738635425,0.287350298372789,FALSE
+"H358","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.45698,1.46,0.107,409,0.661,"CLDN7, MAPK13, RAC2, ITGB2, CLDN4, F11R, CTNNA1, CTNND1, PIK3R3, CLDN3, CTNNB1, CTNNA2, PIK3CD",0.97061622231479,0.17979854051436,FALSE
+"H358","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.57323,-1.77,0.0253,6689,0.186,"ECHS1, ALDH1B1, ALDH7A1, EHHADH, ALDH2",1.59687947882418,0.730487055782084,TRUE
+"H358","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.40407,1.27,0.175,974,0.491,"PLA2G4A, PLA2G12A",0.756961951313706,0.308918507877032,FALSE
+"H358","Input","KEGG_LONG_TERM_DEPRESSION",-0.22166,-0.675,0.89,8896,0.937,"ITPR1, ITPR2, PPP1R17",0.0506099933550872,0.0282604091122217,FALSE
+"H358","Input","KEGG_LONG_TERM_POTENTIATION",0.2607,0.807,0.67,1461,0.802,"PPP3CA, PLCB1, PPP3R2, CAMK2D, RPS6KA1, KRAS, NRAS, PPP3R1, CAMK2G, EP300, CHP1, CREBBP, PRKCG",0.173925197299174,0.0958256317158365,FALSE
+"H358","Input","KEGG_LYSINE_DEGRADATION",-0.34335,-1.05,0.343,7412,0.531,"PLOD1, AASS, OGDH, ALDH7A1, PLOD3, OGDHL, ACAT2, SETDB1, EHHADH, GCDH, ALDH2, TMLHE",0.464705879957229,0.274905478918531,FALSE
+"H358","Input","KEGG_LYSOSOME",-0.42291,-1.28,0.163,6514,0.34,"AP3D1, AP3S1, LAMP2, ENTPD4, GLB1, NEU1, ASAH1, AP3B1, PSAP, AP3M2, LAMP1, CLN5, ARSA, HEXA, GBA, ATP6V0D2, ATP6V0A2, CTSH, CTSA, AP3M1, ACP5, CTSK, CTSO, LIPA, GGA1, TPP1, ATP6V1H, NAPSA, ATP6V0A1, SUMF1, GGA2, CTSZ, HGSNAT, GUSB, AP3S2, IDUA, ACP2, DNASE2, AP1M1, NAGPA, PLA2G15, NAGA, GNS, PPT2, GM2A, IGF2R, CLN3, SMPD1, MAN2B1, HEXB, CD63, ARSB, SLC17A5",0.787812395596042,0.468521082957745,FALSE
+"H358","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.24673,-0.754,0.763,7883,0.895,"FLNC, MAP4K3, TAB1, MAPK8IP3, CACNA2D2, FGFR3, CRKL, MAP3K11, DUSP3, MAP3K7, FGFR4, MAPK12, TGFB1, RELB, ARRB2, MAPK11, TGFB3, MAP2K2, NFKB2, FGFR1, PPP3CC, TAOK3, CRK, DUSP9, RASA2, SOS1, TP53, FGF13, FGF2, STK4, MAPT",0.11747546204512,0.048176964684088,FALSE
+"H358","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.6123,-1.89,0.0179,7830,0.186,"IAPP, HNF1B, PDX1, HNF1A, HNF4A, MNX1, PAX6, NEUROD1",1.74714696902011,0.730487055782084,TRUE
+"H358","Input","KEGG_MELANOGENESIS",-0.24352,-0.748,0.801,6685,0.896,"RAF1, CREB3L2, GNAQ, GSK3B, FZD7, MAPK1, MITF, ASIP, FZD1, TYRP1, DVL3, DVL2, KIT, TCF7L2, MAP2K2, LEF1, DCT, WNT16, WNT11",0.0963674839157623,0.0476919903378748,FALSE
+"H358","Input","KEGG_MELANOMA",-0.30676,-0.953,0.491,8517,0.641,"MAP2K2, CDKN2A, FGFR1, PIK3CB, HGF, TP53, FGF13, FGF2",0.308918507877032,0.193141970481183,FALSE
+"H358","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.53266,-1.58,0.0641,8249,0.234,"GSTO1, CYP3A5, MGST3, GSTK1, AKR1C3, AKR1C1, GSTM3, GSTM1, GSTM2, GSTM4, AKR1C2",1.19314197048118,0.630784142589857,FALSE
+"H358","Input","KEGG_MISMATCH_REPAIR",0.69746,2.18,0.0104,2231,0.182,"PCNA, POLD3, MSH6, RFC3, POLD1, LIG1, MSH2, RFC4, RFC5, RFC2, POLD2, MLH1, RFC1, MSH3, RPA3, RPA2, RPA1",1.98296666070122,0.739928612014925,TRUE
+"H358","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.29271,0.896,0.525,1293,0.745,"CAB39, PIK3R3, PIK3CD, RPS6KB2, HIF1A, RPS6KA1, RPS6KB1, PIK3CA",0.279840696594043,0.127843727251707,FALSE
+"H358","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.43174,1.32,0.136,1461,0.613,"RAC2, ITGB2, LCK, RAET1L, ULBP2, PIK3R3, TNFRSF10A, PIK3CD, PPP3CA, RAC3, PTK2B, PPP3R2, KRAS, NRAS, PPP3R1, PIK3CA, FAS, CHP1, PRKCG",0.866461091629782,0.212539525481585,FALSE
+"H358","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.41402,-1.29,0.184,6579,0.336,"GRIN1, TSPO, PARD3, GRM5, LEPR, P2RX4, TACR1, PRSS3, PLG",0.735182176990464,0.473660722610156,FALSE
+"H358","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24965,0.758,0.778,1612,0.834,"MAPK13, IRS1, RPS6KA4, PIK3R3, PIK3CD, MAPK10, MAPK9, ARHGDIB, CAMK2D, RPS6KA1, KRAS, NRAS, PRKCD, CAMK2G, YWHAZ, KIDINS220, PIK3CA, BAD, FRS2, CSK, SORT1",0.109020403010311,0.0788339493622613,FALSE
+"H358","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.53954,-1.68,0.0353,8626,0.189,"ENPP1, NNMT, BST1, NMNAT3, QPRT",1.45222529461218,0.723538195826756,TRUE
+"H358","Input","KEGG_NITROGEN_METABOLISM",-0.63599,-1.95,0.0152,8024,0.209,"CA1, ASNS, CA8, GLS, GLS2, CPS1, CA12, CA2",1.81815641205523,0.679853713888946,TRUE
+"H358","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23521,-0.735,0.819,7691,0.898,"TRAF6, TAB1, CASP1, MAP3K7, MAPK12, MAPK11, PYCARD, IL6",0.0867160982395816,0.0467236633326956,FALSE
+"H358","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.43034,1.33,0.131,851,0.625,"FEN1, XRCC5, XRCC6",0.882728704344236,0.204119982655925,FALSE
+"H358","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26132,0.802,0.686,1584,0.788,"PIK3R3, RXRA, PIK3CD, RB1, CCND1, ERBB2, RXRG, RXRB, KRAS, NRAS, PIK3CA, PRKCG, BAD",0.163675884293248,0.103473782510445,FALSE
+"H358","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.45266,1.38,0.117,1722,0.68,"NOTCH3, JAG2, JAG1, NCOR2, RBPJ, CTBP1, EP300, CREBBP, KAT2A, DVL1",0.931814138253838,0.167491087293764,FALSE
+"H358","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.53415,1.65,0.0445,2231,0.632,"PCNA, POLD3, RFC3, POLD1, LIG1, RFC4, RFC5, POLE3, RFC2, CUL4A, POLD2, RFC1, DDB2, RBX1, RPA3, POLE2, RPA2, CUL4B, RPA1",1.35163998901907,0.199282921717615,FALSE
+"H358","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.2729,-0.851,0.607,7776,0.75,"ST6GAL1, MGAT4B, DPAGT1, MGAT3, MGAT1, MAN1A1, ALG11, MGAT5",0.216811308924742,0.1249387366083,FALSE
+"H358","Input","KEGG_OLFACTORY_TRANSDUCTION",0.35112,1.07,0.351,1818,0.576,"CAMK2D, CAMK2G, CNGB1",0.454692883534176,0.239577516576788,FALSE
+"H358","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.36155,-1.1,0.308,6496,0.49,"MTHFD2L, MTR, TYMS, GART, ALDH1L1, MTHFR",0.511449283499556,0.309803919971486,FALSE
+"H358","Input","KEGG_OOCYTE_MEIOSIS",0.38869,1.19,0.249,1993,0.495,"CDC20, AR, STAG3, BUB1, CCNB1, PLK1, PPP3CA, CCNB2, MAD2L1, AURKA, PPP3R2, BTRC, CAMK2D, CDK1, RPS6KA1, IGF1R, CDK2, PPP2CB, PPP3R1, CAMK2G, YWHAZ, PPP2R5C, CHP1, PPP2R5E, SMC3, ESPL1, PPP3CB, SMC1A, RBX1, YWHAQ, SMC1B, SGO1",0.603800652904264,0.305394801066431,FALSE
+"H358","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.41248,-1.29,0.162,6428,0.336,"MAN2C1, GLB1, NEU1, HEXA, GBA, MAN2B1, HEXB",0.790484985457369,0.473660722610156,FALSE
+"H358","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.43471,-1.33,0.153,6162,0.327,"ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ATP6V1C1, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, NDUFA10, ATP5F1D, COX7A2L, NDUFA7, NDUFB2, ATP6V1F, COX6B1, ATP5F1B, NDUFS6, ATP6V1D, ATP6V0D2, NDUFV2, ATP5PD, ATP6V0A2, NDUFS3, ATP5F1C, NDUFS8, UQCRB, ATP6V1C2, ATP5ME, ATP6V1A, ATP5F1A, ATP6V1H, ATP6V1B2, ATP6V1B1, NDUFA5, ATP6V0A1, ATP6V1E1, UQCRC1, COX15, ATP5MC2, UQCRFS1, COX11, UQCRC2, ATP6V1G1",0.815308569182401,0.485452247339714,FALSE
+"H358","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.58837,1.84,0.0173,634,0.447,"GALNT13, GALNT7, GALNT3, GALNT10, GALNT6, GALNT15",1.7619538968712,0.349692476868064,FALSE
+"H358","Input","KEGG_P53_SIGNALING_PATHWAY",0.39489,1.24,0.186,1324,0.46,"SERPINB5, THBS1, CHEK1, STEAP3, CCNB1, CCND1, CCNB2, EI24, RRM2, PTEN, CDK1, CDK2, GTSE1, FAS",0.730487055782084,0.337242168318426,FALSE
+"H358","Input","KEGG_PANCREATIC_CANCER",0.36209,1.14,0.276,1088,0.484,"RAC2, PIK3R3, PIK3CD, MAPK10, RB1, MAPK9, RALB, CCND1, ERBB2, SMAD3, RAC3, TGFB2, KRAS",0.559090917934782,0.315154638355588,FALSE
+"H358","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.6089,-1.9,0.0107,6783,0.2,"PANK3, DPYD, PPCS, PANK4, ENPP1, BCAT1",1.97061622231479,0.698970004336019,TRUE
+"H358","Input","KEGG_PARKINSONS_DISEASE",-0.4253,-1.27,0.172,6104,0.337,"SLC18A1, ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, NDUFA10, VDAC2, ATP5F1D, COX7A2L, NDUFA7, NDUFB2, COX6B1, VDAC1, ATP5F1B, CASP9, NDUFS6, NDUFV2, ATP5PD, NDUFS3, HTRA2, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, APAF1, NDUFA5, UQCRC1, UBE2L3, UBA7, UBE2G1, ATP5MC2, UQCRFS1, UBE2J1, UQCRC2, SNCA, UCHL1",0.764471553092451,0.472370099128661,FALSE
+"H358","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.21291,-0.656,0.929,6266,0.941,"ARPC5L, ARPC4, TUBA1C, ARHGEF2, TUBA1B, TUBB1, NCK1, ARPC2, TUBB, TUBA3C, ARPC1B, ARPC5, TUBB2A, CLDN1, WASL, ROCK1, TUBB6, HCLS1, FYN, NCK2, TUBB2B, TUBB4A, ACTG1",0.0319842860063582,0.0264103765727431,FALSE
+"H358","Input","KEGG_PATHWAYS_IN_CANCER",0.29168,0.905,0.57,1132,0.767,"RAC2, LAMC2, PTGS2, SLC2A1, ITGA3, CDH1, LAMB3, AR, LAMA5, CTNNA1, MAX, PIK3R3, PIAS1, CTNNB1, CTNNA2, RXRA, PIK3CD, MAPK10, RB1, MAPK9, RUNX1, RALB, CCND1, MSH6, ETS1, ERBB2, RXRG, PTEN, SMAD3, MSH2, SKP2, RAC3, CTBP1, HIF1A, MECOM, MET, CKS1B, TGFB2, RXRB, KRAS, NRAS, IGF1R, ITGA6, CDK2, FZD6",0.244125144327509,0.115204636051019,FALSE
+"H358","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.50067,-1.53,0.0751,7692,0.25,"RPE, CRYL1, GUSB, XYLB, AKR1B1",1.12436006299583,0.602059991327962,FALSE
+"H358","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.34873,-1.04,0.374,6220,0.533,"PRPS1, PRPS1L1, TALDO1, PFKP, PFKM, PFKL, RPE, GPI, DERA, H6PD, PGLS",0.42712839779952,0.273272790973428,FALSE
+"H358","Input","KEGG_PEROXISOME",-0.44496,-1.37,0.117,7272,0.32,"HSD17B4, DHRS4, DAO, PXMP4, PRDX1, MLYCD, ECI2, IDH1, PEX5, PECR, DECR2, CAT, CRAT, ABCD1, HACL1, AGXT, IDH2, ACSL5, EHHADH, GSTK1, SOD1, FAR2, SOD2, NUDT19, PHYH, ECH1",0.931814138253838,0.494850021680094,FALSE
+"H358","Input","KEGG_PHENYLALANINE_METABOLISM",-0.35979,-1.12,0.292,8710,0.469,"GOT1, MAOB, DDC",0.534617148551582,0.328827157284917,FALSE
+"H358","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.27855,-0.873,0.609,6782,0.736,"PIP4K2A, PIP4K2B, PIK3C2A, PIK3R2, SYNJ1, PIK3C2B, OCRL, PIP5K1C, ITPR3, PLCG1, INPP5D, PIK3C3, INPP5K, PIKFYVE, PLCG2, PIK3R1, ITPKA, IMPA1, ITPK1, PIK3CB, ITPKB, ITPR1, ITPR2",0.215382707367125,0.133122185662501,FALSE
+"H358","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.42796,-1.31,0.151,7931,0.327,"CPOX, GUSB, EARS2, HMOX1, COX15, BLVRA, UROS, BLVRB, FTH1",0.821023052706831,0.485452247339714,FALSE
+"H358","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.4506,-1.36,0.136,7615,0.324,"FABP5, APOA1, OLR1, SCD, ILK, SLC27A6, ACSL5, EHHADH, HMGCS2, SLC27A1, APOA2, SORBS1, PCK2, GK, FABP1, CYP27A1, FABP7, FABP3",0.866461091629782,0.489454989793388,FALSE
+"H358","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.59486,-1.85,0.022,6247,0.183,"ACOX2, AMACR, HSD17B4, AKR1D1, CYP27A1",1.65757731917779,0.737548910269571,TRUE
+"H358","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.41778,1.31,0.154,583,0.547,"LCK, UNG",0.812479279163537,0.262012673666569,FALSE
+"H358","Input","KEGG_PRION_DISEASES",-0.57953,-1.82,0.0306,8236,0.189,"FYN, BAX, C5, MAP2K2, SOD1, C9, IL6",1.51427857351842,0.723538195826756,TRUE
+"H358","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.45866,1.37,0.137,1098,0.656,"MAPK13, FZR1, CCNA2, PIK3R3, BUB1, PIK3CD, MAPK10, CCNB1, PLK1, MAPK9, CCNB2, MAD2L1, CDK1, RPS6KA1, KRAS, IGF1R, CDK2",0.863279432843593,0.18309616062434,FALSE
+"H358","Input","KEGG_PROPANOATE_METABOLISM",-0.57885,-1.8,0.0194,6689,0.175,"ECHS1, ALDH1B1, PCCA, ACADM, MLYCD, ALDH7A1, ACAT2, ACSS1, ACSS2, ACSS3, PCCB, EHHADH, MCEE, ALDH2, ABAT",1.71219827006977,0.756961951313706,TRUE
+"H358","Input","KEGG_PROSTATE_CANCER",0.26226,0.807,0.665,1404,0.802,"AR, PIK3R3, CTNNB1, PIK3CD, RB1, CCND1, ERBB2, PTEN, KRAS, NRAS, IGF1R, CDK2, PIK3CA, EP300, CREBBP",0.177178354696895,0.0958256317158365,FALSE
+"H358","Input","KEGG_PROTEASOME",0.17383,0.543,0.993,1486,0.987,"PSME1, PSME2, PSMB8, PSME3",0.00305075150461883,0.00568284733036327,FALSE
+"H358","Input","KEGG_PROTEIN_EXPORT",-0.17313,-0.529,0.99,8519,0.991,"SEC11C, IMMP1L",0.00436480540245009,0.00392634551472468,FALSE
+"H358","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.54988,-1.67,0.0506,8513,0.188,"GLS, GLS2, ATP1B3, PCK2, AQP1, CA2",1.2958494831602,0.72584215073632,FALSE
+"H358","Input","KEGG_PURINE_METABOLISM",0.26219,0.828,0.665,982,0.785,"PDE5A, NT5E, POLA1, PRIM1, PRIM2, PKM, POLD3, NME7, POLD1, RRM2, NME3, POLA2, POLE3, POLR3C, PDE4D, POLR3F, ENTPD6, POLR3B, DCK, POLR3G",0.177178354696895,0.105130343254747,FALSE
+"H358","Input","KEGG_PYRIMIDINE_METABOLISM",0.39848,1.25,0.193,1339,0.475,"CDA, NT5E, POLA1, PRIM1, DUT, PRIM2, POLD3, NME7, POLD1, RRM2, UCK2, NME3, POLA2, POLE3, POLR3C, POLR3F, ENTPD6, POLR3B, DCK, POLR3G, TK1, TK2, PNP, UCK1, POLD2",0.714442690992226,0.323306390375133,FALSE
+"H358","Input","KEGG_PYRUVATE_METABOLISM",-0.45103,-1.39,0.118,7460,0.334,"ACYP1, PC, ALDH7A1, GRHPR, ACAT2, ACSS1, ACSS2, PCK2, AKR1B1, ALDH2, HAGH",0.928117992693875,0.476253533188435,FALSE
+"H358","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.21013,-0.659,0.928,7837,0.948,"ITGA1, GSN, PIKFYVE, PIK3R1, DOCK1, FGFR3, ENAH, CRKL, VCL, FGFR4, MYH10, ARHGEF6, FGD1, MAP2K2, FN1, FGFR1, ITGB8, PIK3CB, CRK, ITGB3, ACTG1, SOS1, IQGAP2, ITGA5, ITGA7, FGF13, FGF2, ITGA4",0.0324520237811379,0.0231916626619338,FALSE
+"H358","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.57295,-1.76,0.0382,6267,0.181,"PRKAA1, PIK3R4, PRKAA2, ATG3, ATG4A, ULK1, PIK3C3, ATG12, ATG4B, GABARAPL1, ULK3",1.41793663708829,0.742321425130815,TRUE
+"H358","Input","KEGG_RENAL_CELL_CARCINOMA",0.25478,0.766,0.748,1980,0.843,"SLC2A1, PIK3R3, PIK3CD, ETS1, HIF1A, MET, TGFB2, KRAS, NRAS, PIK3CA, EP300, CREBBP, ELOC, CDC42, RBX1, ELOB, JUN",0.126098402135539,0.0741724253752577,FALSE
+"H358","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.53302,-1.64,0.0363,7507,0.202,"CTSA, ENPEP, ACE, AGT, ANPEP",1.44009337496389,0.694648630553376,TRUE
+"H358","Input","KEGG_RETINOL_METABOLISM",-0.38819,-1.21,0.234,8270,0.381,"CYP3A5, RDH10, ALDH1A2, ALDH1A1",0.630784142589857,0.419075024324381,FALSE
+"H358","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.43072,-1.33,0.129,7532,0.327,"ACP5, MTMR6, ACP2, ENPP1, PHPT1",0.889410289700751,0.485452247339714,FALSE
+"H358","Input","KEGG_RIBOSOME",0.27159,0.859,0.619,3836,0.772,"RPS4Y1, RPL22, FAU, RPS23, RPS25, RPS3A, RPL23A, RPL8, RPS11, RPS8, RPS29, RPL7, RPL34, RPS5, RPL28, RPL7A, RPS15, RPS13, RPL10, RPL18, RPS27L, RPL26, RPS17, RPS9, RPL37A, RPL36A, RPL36AL, RPS2, RPS6, RPL36, RPL15, RPL21, RPS18, RPL17, RPL10A, RPL5, RPL27, RPL19, RPL18A, RPL11, RPL14, RPL32, RPL13A, RPS16, MRPL13, RPL13",0.208309350979882,0.112382699664264,FALSE
+"H358","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37634,1.15,0.251,952,0.493,"MAPK13, DDX3Y, ISG15, MAPK10, MAPK9, DDX58, TKFC",0.600326278518962,0.30715308072277,FALSE
+"H358","Input","KEGG_RNA_DEGRADATION",0.31524,0.984,0.438,2938,0.701,"XRN2, PAPOLA, EXOSC5, EXOSC6, DCPS, PAPOLG, EXOSC9, EXOSC8, EXOSC7, ENO1, DIS3, ENO3, EXOSC3, EXOSC10, EXOSC2, CNOT6, CNOT6L, MTREX, DDX6, DCP1A, LSM6, LSM8, LSM1, EXOSC1, LSM2",0.3585258894959,0.154281982033341,FALSE
+"H358","Input","KEGG_RNA_POLYMERASE",0.41045,1.28,0.174,3305,0.532,"POLR3C, POLR3F, POLR3B, POLR3G, POLR3A, POLR2K, POLR1B, POLR3H, POLR1A, POLR3D, POLR1E, POLR1C, POLR1D, POLR3K, POLR2B",0.7594507517174,0.274088367704952,FALSE
+"H358","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.23458,-0.727,0.83,6033,0.901,"SEPHS2, AHCY, MAT2B, METTL2B, TRMT11, GGT7, GGT1, LCMT1, PAPSS2",0.0809219076239261,0.045275209020937,FALSE
+"H358","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.41269,1.27,0.186,1098,0.491,"LAMC2, PTGS2, ITGA3, LAMB3, LAMA5, MAX, PIK3R3, PIAS1, RXRA, PIK3CD, RB1, CCND1, RXRG, PTEN, SKP2, CKS1B, RXRB, ITGA6, CDK2",0.730487055782084,0.308918507877032,FALSE
+"H358","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.23245,-0.713,0.833,6730,0.913,"SNAP25, USE1, GOSR2, VAMP7, VAMP5, SNAP29, STX7, BET1, YKT6, STX2",0.0793549985932124,0.039529222465701,FALSE
+"H358","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.24352,-0.738,0.781,6538,0.903,"SGPP1, GLB1, NEU1, ASAH1, ARSA, UGCG, GBA, KDSR, SMPD2, SMPD3, PLPP1, SMPD1",0.1073489661227,0.0443122496864942,FALSE
+"H358","Input","KEGG_SPLICEOSOME",0.40037,1.24,0.191,3679,0.46,"DHX8, DHX15, ALYREF, DDX42, SNRPB2, DHX16, CTNNBL1, DDX5, SNRPA1, HSPA2, PRPF3, AQR, CDC5L, SF3B1, NCBP1, DHX38, DDX46, U2AF2, SRSF5, CRNKL1, PUF60, SF3B3, RBMX, SRSF8, DDX39B, CWC15, SNRPE, BCAS2, PRPF4, PHF5A, SART1, HSPA1A, PLRG1, SNRPD1, SNRPD2, XAB2, SNRNP200, LSM6, EIF4A3, PRPF19, THOC1, SF3B4, RBM25, LSM8, USP39, SF3B6, SRSF9, LSM2, SF3A3, TRA2A, HNRNPM, HNRNPA1, SNW1, PRPF40A, SNRPB, ISY1, SF3B5, PRPF38A, SNRPA, U2AF1, PRPF8, LSM3, SF3A1, PPIL1, SNRPD3, SRSF6, HNRNPK, HSPA6, SRSF2, PRPF31, THOC2, PRPF6, SNRNP70",0.718966632752272,0.337242168318426,FALSE
+"H358","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.22692,-0.686,0.881,7549,0.933,"GYS1, GPI, GUSB, ENPP1, SI, UXS1",0.0550240915879521,0.0301183562535,FALSE
+"H358","Input","KEGG_STEROID_BIOSYNTHESIS",-0.49274,-1.49,0.0857,7665,0.267,"CEL, LIPA, SOAT2, FDFT1, SQLE",1.0670191780768,0.573488738635425,FALSE
+"H358","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.72859,-2.18,0.00743,8270,0.189,"CYP3A5, AKR1D1, CYP21A2, HSD3B1, AKR1C3, HSD17B2, AKR1C1, HSD11B2, AKR1C2",2.12901118623942,0.723538195826756,TRUE
+"H358","Input","KEGG_SULFUR_METABOLISM",-0.7871,-2.43,0,7602,0.0599,"SULT1A3, CHST13, SUOX, PAPSS2, CHST12, CHST11, SULT1A1",Inf,1.22257317761069,TRUE
+"H358","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.40922,-1.27,0.16,6645,0.337,"ELANE, CD40, TRIM21, C3, C5, C4A, C9",0.795880017344075,0.472370099128661,FALSE
+"H358","Input","KEGG_TASTE_TRANSDUCTION",0.47947,1.5,0.0983,1100,0.794,"SCNN1B, CACNA1A",1.00744648216786,0.100179497572904,FALSE
+"H358","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.50306,-1.56,0.0649,7194,0.232,"PDSS2, GGPS1, HMGCR, HMGCS1, ACAT2, HMGCS2, IDI1",1.18775530319963,0.6345120151091,FALSE
+"H358","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.2907,0.886,0.572,1404,0.754,"SMURF1, THBS1, ID1, RPS6KB2, SMAD3, RBL1, ACVR1, TGFB2, PPP2CB, RPS6KB1, SMURF2, EP300, CREBBP",0.242603971206976,0.122628654130226,FALSE
+"H358","Input","KEGG_THYROID_CANCER",0.37034,1.14,0.264,1089,0.484,"CDH1, CTNNB1, RXRA, CCND1, RXRG, RXRB, KRAS, NRAS",0.578396073130169,0.315154638355588,FALSE
+"H358","Input","KEGG_TIGHT_JUNCTION",0.4082,1.27,0.172,1464,0.491,"CLDN7, PRKCH, CLDN4, F11R, CTNNA1, CLDN3, CTNNB1, CTNNA2, LLGL2, PATJ, CRB3, CASK, PTEN, MYH9, MYH11, RAB13, CSNK2A1, CSNK2A2, TJP1, MAGI3, CGN, KRAS, NRAS, EPB41L1, PPP2CB, TJP2, PRKCD, OCLN, PRKCZ, MYL12A, PRKCG, CSNK2B",0.764471553092451,0.308918507877032,FALSE
+"H358","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.26182,-0.801,0.707,6324,0.827,"MAPK8, RELA, IKBKG, AKT3, IRF3, TRAF3, CHUK, TBK1, CD40, PIK3R2, RIPK1, MAPK1, SPP1, IRAK4, CTSK, TRAF6, LBP, TAB1, PIK3R1, MAP3K7, MAPK12, MAPK11, TOLLIP, MAP2K2, PIK3CB, IFNAR2, IL6",0.150580586203101,0.0824944904474534,FALSE
+"H358","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.55285,-1.71,0.0405,7375,0.186,"AOC1, KYNU, OGDH, ALDH7A1, CAT, OGDHL, ACAT2, EHHADH, MAOB, DDC, GCDH, ALDH2",1.39254497678533,0.730487055782084,TRUE
+"H358","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.48852,1.52,0.0811,1342,0.848,"IRS1, PIK3R3, PIK3CD, MAPK10, PKM, MAPK9, ABCC8, CACNA1A, PRKCD, PIK3CA, PRKCZ, PKLR",1.09097914578884,0.0716041477432862,FALSE
+"H358","Input","KEGG_TYROSINE_METABOLISM",0.32926,1.02,0.354,410,0.642,"ALDH1A3, ADH4, ADH7, MAOA",0.450996737974212,0.192464971931147,FALSE
+"H358","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.27725,0.857,0.624,1362,0.764,"MAPK13, LCK, PIK3R3, PIK3CD, MAPK9, PPP3CA, PPP3R2, KRAS, NRAS, PPP3R1, TEC, PIK3CA, CHP1",0.204815410317576,0.11690664142431,FALSE
+"H358","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29576,0.909,0.523,2737,0.772,"FZR1, CDC20, UBE2C, SMURF1, PIAS1, UBE2E2, FANCL, UBE2S, UBE3A, WWP2, SKP2, CUL4A, UBE2W, BTRC, CUL3, UBR5, UBE2O, SMURF2, ITCH, UBA3, DDB2, ELOC, PIAS3, BRCA1, RBX1, ELOB, UBE4A, CUL4B, PPIL2, MAP3K1, RNF7, UBE2A, CUL5, MID1, UBA6, COP1, PML, DDB1, UBE2D2, UBE2K, UBE4B, PRPF19",0.281498311132726,0.112382699664264,FALSE
+"H358","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.61649,-1.86,0.0212,8770,0.192,"BCAT1",1.67366413907125,0.71669877129645,TRUE
+"H358","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.51404,-1.58,0.0585,7819,0.234,"ALDH7A1, ACADS, HMGCS1, BCKDHB, ACAT2, PCCB, EHHADH, MCEE, HMGCS2, BCAT1, ALDH2, ACADSB, ABAT, ACAA2",1.23284413391782,0.630784142589857,FALSE
+"H358","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.24199,0.764,0.744,1186,0.835,"PRKCH, PPP1R14A, PLA2G4A, PLCB1, MYL6, MYH11, MYLK, PLA2G12A, PRKCD",0.128427064454121,0.0783135245163979,FALSE
+"H358","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.29197,-0.901,0.524,5911,0.71,"DYNC1I2, DYNC2LI1, RAB5C, DYNC2H1, PRKACB, CREB5, RAB5B, CREB3L2, DYNC1LI1, DCTN4, DCTN6, DCTN5, DYNLL1, DCTN1, DCTN2",0.280668713016273,0.148741651280925,FALSE
+"H358","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.43288,1.31,0.159,1829,0.547,"MAPK13, RAC2, PTGS2, PIK3R3, PIK3CD, PLA2G4A, PPP3CA, RAC3, PPP3R2, PLA2G12A, KRAS, NRAS, PPP3R1, PIK3CA, CHP1, PRKCG, BAD, PPP3CB, CDC42",0.798602875679548,0.262012673666569,FALSE
+"H358","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.43673,-1.34,0.142,7218,0.331,"ATP6V1D, ATP6V0D2, ATP6V0A2, PDIA4, ATP6V1C2, PLCG1, ATP6V1A, ATP6V1H, ATP6V1B2, ATP6V1B1, ATP6V0A1, ATP6V1E1, PLCG2, KDELR1, ACTG1, ATP6V1G1",0.847711655616944,0.480172006224281,FALSE
+"H358","Input","KEGG_VIRAL_MYOCARDITIS",0.41889,1.3,0.158,984,0.519,"RAC2, ITGB2, CAV1, CCND1, MYH9, RAC3, MYH11, DAG1, CD55",0.801342913045577,0.284832642151542,FALSE
+"H358","Input","KEGG_WNT_SIGNALING_PATHWAY",0.43014,1.31,0.174,1464,0.547,"RAC2, NKD2, CTNNB1, CHD8, FOSL1, MAPK10, VANGL1, MAPK9, CCND1, PPP3CA, SMAD3, RAC3, CTBP1, DKK1, TBL1X, PLCB1, CSNK1E, DAAM1, TBL1XR1, PPP3R2, BTRC, CSNK2A1, CSNK2A2, CAMK2D, PPP2CB, PPP3R1, FZD6, CAMK2G, PPP2R5C, EP300, CHP1, PPP2R5E, CREBBP, PRKCG, CSNK2B",0.7594507517174,0.262012673666569,FALSE
+"A549","Input","KEGG_ABC_TRANSPORTERS",0.66076,1.96,0.00858,292,0.384,"ABCC2, ABCA1, ABCG2, ABCC8, ABCC3, ABCC1, ABCC4",2.06651271215129,0.415668775632469,FALSE
+"A549","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.38087,-1.07,0.342,6338,0.697,"FLT3, TCF7L1, RELA, IKBKB, MTOR, STAT5A, TCF7L2, SOS1, MAP2K1, PIK3CD, MAP2K2, BRAF, EIF4EBP1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PML, PIK3CB, NFKB1, AKT1, MAPK1, RUNX1, MAPK3",0.465973893943865,0.156767221901991,FALSE
+"A549","Input","KEGG_ADHERENS_JUNCTION",-0.25827,-0.753,0.803,8178,0.898,"AFDN, WAS, WASF2, CTNNA1, PTPN6, FARP2, CDH1, MAPK1, ERBB2, ACTG1, MAPK3, NECTIN1, BAIAP2, NECTIN4, RAC2",0.095284454721319,0.0467236633326956,FALSE
+"A549","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.28132,-0.806,0.717,6358,0.845,"ACACB, RELA, ADIPOR1, IKBKB, MTOR, TRADD, MAPK9, PRKAA1, RXRA, RXRB, NFKBIE, MAPK10, CPT1A, NFKBIA, NFKB1, AKT1, ACSL1, ACSL5, STK11",0.1444808443322,0.0731432910503077,FALSE
+"A549","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.40005,-1.13,0.291,8462,0.693,"ASNS, GFPT1, ADSL, ASL, GPT2, IL4I1, ABAT, ASS1, GLUL, DDO",0.536107011014093,0.159266765388193,FALSE
+"A549","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.54035,-1.53,0.0686,7844,0.943,"PIK3R1, ATP1B1, KRAS, SCNN1G, PIK3CA, ATP1A1, ATP1A4, ATP1A3, PIK3CB, ATP1B3, MAPK1, MAPK3, PDPK1, HSD11B2, SCNN1A",1.16367588429325,0.0254883072626717,FALSE
+"A549","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.51331,-1.46,0.0895,9161,0.76,"PLA2G12A, PLA2G2A",1.04817696468409,0.119186407719209,FALSE
+"A549","Input","KEGG_ALZHEIMERS_DISEASE",-0.21812,-0.615,0.957,8450,1,"PLCB1, FADD, COX7C, CACNA1F, CALM2, CASP3, MAPK1, MAPT, PLCB3, SNCA, CAPN1, MAPK3, MME, LPL",0.0190880622231565,0,FALSE
+"A549","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29233,-0.839,0.618,5457,0.816,"NARS2, FARSB, IARS2, SEPSECS, RARS2, SARS2, AARS2, DARS2, VARS2, WARS2, LARS2, FARSA, PARS2, TARS2, MARS2, CARS2",0.209011524911184,0.0883098412461389,FALSE
+"A549","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.50313,-1.45,0.0796,7876,0.682,"GALK2, NANS, CYB5R1, GNPNAT1, GMPPB, GALE, PGM3, PGM1, GMPPA, GFPT1, HEXB, HK2, FPGT, RENBP, GCK, AMDHD2, UAP1, MPI, PGM2, HK1, GMDS",1.09908693226233,0.166215625343521,FALSE
+"A549","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.37017,1.1,0.308,1061,0.599,"NEFH, PRPH, PRPH2, GPX1, NEFL, BAD, MAP2K6, BCL2L1, PPP3R1",0.511449283499556,0.222573177610689,FALSE
+"A549","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.3026,-0.881,0.58,9089,0.778,"PSME2, PSME1, IFI30, CD74, B2M",0.236572006437063,0.109020403010311,FALSE
+"A549","Input","KEGG_APOPTOSIS",-0.21555,-0.613,0.941,7315,1,"PIK3CD, CASP10, RIPK1, MYD88, ENDOD1, PRKAR1B, CASP7, PIK3R1, PIK3CA, NFKBIA, IRAK4, FADD, PRKAR2B, PIK3CB, CASP3, NFKB1, AKT1, IL1RAP, CAPN1, BCL2, IL1A",0.0264103765727431,0,FALSE
+"A549","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.35969,-1.02,0.373,9161,0.718,"PLA2G12A, PTGS1, GPX6, GPX7, PLA2G2A, ALOX5",0.428291168191312,0.1438755557577,FALSE
+"A549","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.34839,-1,0.408,8468,0.749,"LAP3, ACY1, MAOB, ASL, PRODH, PRODH2, MAOA, CKB, ARG1, ASS1, CKMT2, GLUL, ARG2, CKMT1A",0.38933983691012,0.125518182300534,FALSE
+"A549","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.55562,1.63,0.0437,720,0.364,"DES, GJA1, ITGA3, CDH2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ACTN1, ACTN4, ATP2A2",1.35951856302958,0.438898616350944,FALSE
+"A549","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.57996,1.71,0.0382,1107,0.4,"ALDH2, ALDH1B1, UGDH, ALDH3A2",1.41793663708829,0.397940008672038,FALSE
+"A549","Input","KEGG_AXON_GUIDANCE",-0.36138,-1.02,0.401,7702,0.718,"RAC1, PAK2, ABLIM3, EPHB3, GSK3B, RASA1, DPYSL5, KRAS, NRAS, ROCK1, ARHGEF12, PAK3, NCK2, NTN1, CXCR4, PAK1, EPHA4, ROBO2, LIMK2, MAPK1, PLXNA3, SLIT1, SLIT3, EPHA1, MAPK3, PLXNA2, SLIT2, PAK5, PAK6, UNC5B, NFATC2, EFNB2, RAC2",0.396855627379818,0.1438755557577,FALSE
+"A549","Input","KEGG_BASAL_CELL_CARCINOMA",0.3861,1.13,0.259,907,0.616,"FZD2, FZD7, SUFU",0.586700235918748,0.210419287835575,FALSE
+"A549","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.32275,0.944,0.456,852,0.749,"GTF2E1, STON1, GTF2E2",0.341035157335565,0.125518182300534,FALSE
+"A549","Input","KEGG_BASE_EXCISION_REPAIR",0.38329,1.13,0.27,2845,0.616,"NEIL2, POLL, POLE3, POLE4, NTHL1, XRCC1, POLD4, POLD3, POLD1, POLB, MPG, POLD2, TDG, MBD4",0.568636235841013,0.210419287835575,FALSE
+"A549","Input","KEGG_BETA_ALANINE_METABOLISM",0.3743,1.12,0.256,1107,0.597,"ALDH2, ALDH1B1, ALDH3A2",0.59176003468815,0.224025668870631,FALSE
+"A549","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.59604,1.74,0.0321,943,0.427,"SCD5, HACD1, ACOT2, ELOVL5, FADS1, FADS2, PECR",1.49349496759513,0.369572124974976,FALSE
+"A549","Input","KEGG_BLADDER_CANCER",-0.31342,-0.894,0.571,7636,0.771,"MAP2K2, BRAF, RASSF1, RAF1, THBS1, TYMP, KRAS, NRAS, E2F1, CDH1, MAPK1, RPS6KA5, CDKN2A, ERBB2, MAPK3",0.243363891754152,0.112945621949043,FALSE
+"A549","Input","KEGG_BUTANOATE_METABOLISM",-0.37138,-1.06,0.351,8830,0.704,"ACAT2, AACS, ABAT, HMGCS2, OXCT1, BDH1",0.454692883534176,0.152427340857888,FALSE
+"A549","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52515,-1.5,0.079,7558,0.943,"NFKBIE, MAP2K2, RAC1, VAV2, GSK3B, RAF1, PIK3R1, KRAS, NRAS, VAV1, BTK, PIK3CA, PLCG2, PTPN6, BCL10, NFKBIA, VAV3, CD79B, PIK3CB, NFKB1, AKT1, MAPK1, INPP5D, MAPK3, FOS, SYK, CARD11, NFATC2, DAPP1, RAC2",1.10237290870956,0.0254883072626717,FALSE
+"A549","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.38447,1.17,0.241,1261,0.602,"CD38, MYLK, BST1, PLCB4, PRKCG, ITPR1, ATP2B1, PRKCB, PLCD3, ATP2A2, TACR1, ADCY3, ADCY8, PPP3R1, SPHK2, GNAQ, PHKA1, PRKACA, PRKCA",0.617982957425132,0.220403508742175,FALSE
+"A549","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.42487,1.26,0.192,803,0.603,"TPM2, TPM1, CACNA2D2, CACNA2D1, ATP2A2, TPM4",0.71669877129645,0.219682687859849,FALSE
+"A549","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.40097,-1.14,0.257,9212,0.687,"ICOSLG, SDC3, NCAM1, NECTIN1, ITGAL, SDC2, ITGB8, CLDN11, CDH15, CDH3, CLDN3, CLDN7, CLDN4, CLDN18",0.590066876668705,0.16304326294045,FALSE
+"A549","Input","KEGG_CELL_CYCLE",0.20691,0.617,0.958,2255,0.968,"CDKN1A, TGFB2, MDM2, CCNB3, ANAPC11, ANAPC10, SMAD3, SMAD2, ATR, YWHAQ, PRKDC, STAG1, CCND1, ATM, CDC26, CDK6, CDC25B, TFDP2, ORC5, ANAPC4, BUB3, CDK4, MAD1L1, CDKN1B, CDC27",0.0186344909214556,0.0141246426916063,FALSE
+"A549","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.33049,-0.953,0.474,7315,0.77,"PIK3CD, GNAI2, PREX1, CCR4, PTK2B, RAP1B, CCL13, GRK6, BRAF, RAC1, VAV2, GSK3B, RAF1, GRK5, PIK3R1, CCL15, KRAS, NRAS, VAV1, PIK3CA, ROCK1, PLCB2, WAS, NFKBIA, VAV3, PRKCD, PLCB1, CXCR4, CRKL, PAK1, PIK3CB, GNG10, ARRB1, NFKB1, AKT1, MAPK1, GNG2, GRK2, PLCB3, GNG5, PRKCZ, MAPK3, STAT2, RAC2",0.324221658325915,0.113509274827518,FALSE
+"A549","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.27277,-0.787,0.725,7636,0.853,"MAP2K2, BRAF, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, HDAC1, CBLB, NFKBIA, E2F1, CRKL, PIK3CB, NFKB1, AKT1, MAPK1, BCR, CDKN2A, RUNX1, MAPK3, CBL, MECOM",0.139661993429006,0.069050968832477,FALSE
+"A549","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.62733,-1.79,0.0153,9641,0.505,"PER3",1.8153085691824,0.296708621881339,FALSE
+"A549","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.17608,-0.507,0.995,6120,1,"PCK2, CS, ACO1, MDH2, SUCLA2, OGDHL, IDH1, DLD, OGDH, ACO2, MDH1, DLAT, IDH2",0.00217691925427455,0,FALSE
+"A549","Input","KEGG_COLORECTAL_CANCER",-0.30952,-0.9,0.57,7566,0.789,"MAPK10, BRAF, RAC1, GSK3B, RAF1, CTNNB1, PIK3R1, KRAS, PIK3CA, PIK3CB, CASP3, AKT1, MAPK1, BIRC5, MAPK3, FOS, BCL2, RAC2",0.244125144327509,0.10292299679058,FALSE
+"A549","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.55397,1.66,0.0255,1069,0.366,"FGA, C1S, THBD, C9, SERPINE1, PLAUR, SERPIND1, TFPI, PLAU, MASP1, CD59, C1R, F3",1.59345981956604,0.436518914605589,FALSE
+"A549","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.32168,-0.919,0.514,8482,0.78,"CBS, ENOPH1, IL4I1, MTAP, CTH",0.289036881004724,0.10790539730952,FALSE
+"A549","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33143,0.989,0.404,1199,0.718,"TGFB2, CXCL5, EDAR, OSMR, TNFRSF10D, TGFBR2, TNFRSF12A, TGFBR1, TNFRSF10C, KITLG, CD70, TNFRSF10A, ACVR1, IL18, TNFRSF10B, ACVR1B, IL6ST, CD40",0.393618634889395,0.1438755557577,FALSE
+"A549","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.32311,-0.931,0.494,9447,0.774,"DDX58, RIPK3, CASP1",0.306273051076353,0.111259039317107,FALSE
+"A549","Input","KEGG_DILATED_CARDIOMYOPATHY",0.615,1.83,0.0211,911,0.471,"TPM2, DES, TPM1, ITGA3, TGFB2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ATP2A2, TPM4, ADCY3, ADCY8, ITGA1",1.67571754470231,0.326979092871104,FALSE
+"A549","Input","KEGG_DNA_REPLICATION",0.24818,0.718,0.843,2823,0.936,"POLE3, POLE4, RNASEH1, POLA2, POLD4, POLD3, SSBP1, POLD1, POLA1, PRIM2, POLD2, PRIM1, RNASEH2A",0.0741724253752577,0.0287241512618947,FALSE
+"A549","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.49682,-1.41,0.119,7112,0.557,"SOS1, MAP2K1, ETV6, KRAS, NOTCH2, MAPK1, MAPK3",0.924453038607469,0.254144804826271,FALSE
+"A549","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.50471,-1.43,0.0918,8431,0.644,"GSTA2, UGT2B17, MAOB, FMO2, FMO4, FMO5, ALDH1A3, MAOA, GSTM3, ADH4, ADH7, ADH1C, GSTM4",1.03715731879876,0.191114132640188,FALSE
+"A549","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.36841,-1.07,0.318,5976,0.697,"UGT2B11, UGT2B4, UCK2, HPRT1, GUSB, NAT1, ITPA, UPP1, UCKL1, XDH, TYMP, CES1, CES2, TPMT, UGT2B17",0.497572880015567,0.156767221901991,FALSE
+"A549","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.46992,1.37,0.115,402,0.515,"COL5A2, COL4A1, COL5A1, COL4A2, ITGA3, ITGA5, ITGB1, ITGB5, LAMB1, CD44, ITGAV, FN1, ITGB3, SPP1",0.939302159646388,0.288192770958809,FALSE
+"A549","Input","KEGG_ENDOCYTOSIS",-0.23839,-0.671,0.88,8085,0.994,"PRKCI, PARD6A, ARFGAP2, DNM2, RAB22A, CBLB, RNF41, RAB11B, DNAJC6, CXCR4, VPS37B, CHMP4A, CHMP4B, SH3GLB1, ARRB1, VPS4B, ARAP1, ACAP2, GRK2, CHMP4C, ERBB4, PRKCZ, FGFR2, SH3GL2, LDLR, CBL, ARAP2, RAB11FIP4, ERBB3, PSD4, EPN3",0.0555173278498314,0.00261361560268669,FALSE
+"A549","Input","KEGG_ENDOMETRIAL_CANCER",-0.36937,-1.07,0.345,7636,0.697,"MAP2K2, BRAF, GSK3B, RAF1, CTNNB1, PIK3R1, CTNNA2, KRAS, NRAS, PIK3CA, CTNNA1, PIK3CB, CDH1, AKT1, MAPK1, ERBB2, MAPK3, PDPK1",0.462180904926726,0.156767221901991,FALSE
+"A549","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.48793,-1.41,0.0975,7392,0.557,"TCIRG1, ATP6V0C, ATP6V0D1, MAPK10, RAC1, ATP6V0A1, MAPK14, PLCG2, ATP6AP1, ATP6V1C1, F11R, ATP6V1E1, NFKBIA, ATP6V1B2, ATP6V1F, PAK1, ATP6V1A, CASP3, NFKB1, ATP6V1H, ATP6V1D, ATP6V1B1, ATP6V1G1, MAPK12",1.01099538430146,0.254144804826271,FALSE
+"A549","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.28073,-0.803,0.689,7566,0.831,"MAPK10, AREG, MAP2K2, BRAF, EIF4EBP1, PAK2, GSK3B, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PAK3, PLCG2, NCK2, CBLB, CRKL, PAK1, PIK3CB, AKT1, MAPK1, ERBB2, ERBB4, MAP2K7, MAPK3, CBL, PAK5, PAK6, ERBB3",0.161780778092374,0.080398976215889,FALSE
+"A549","Input","KEGG_ETHER_LIPID_METABOLISM",0.37443,1.12,0.282,1996,0.597,"PLPP1, PLA2G4A, PLPP3, CHPT1, PLD2, PLPP2, AGPS",0.549750891680639,0.224025668870631,FALSE
+"A549","Input","KEGG_FATTY_ACID_METABOLISM",-0.46214,-1.35,0.133,8234,0.605,"ALDH9A1, CPT1A, ACADM, ACAT2, ACSL1, GCDH, CPT2, ADH4, ADH7, ACSL5, ADH1C",0.876148359032914,0.218244625347531,FALSE
+"A549","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.49999,-1.44,0.0911,7090,0.662,"MAPK9, SOS1, MAP2K1, PIK3CD, GAB2, MAP2K3, MAPK10, MAP2K2, RAC1, VAV2, RAF1, PIK3R1, KRAS, NRAS, VAV1, BTK, PIK3CA, MAPK14, PLCG2, VAV3, PRKCD, PIK3CB, AKT1, MAPK1, INPP5D, MAP2K7, PLA2G12A, MAPK3, PDPK1, SYK, PLA2G2A, MAPK12, RAC2",1.040481623027,0.1791420105603,FALSE
+"A549","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.29827,-0.846,0.66,7702,0.811,"RAC1, VAV2, RAF1, PIK3R1, VAV1, PTPRC, PIK3CA, WAS, WASF2, DNM2, PLCG2, VAV3, PRKCD, SPHK1, CRKL, PAK1, PIK3CB, GSN, LIMK2, AKT1, MAPK1, INPP5D, AMPH, MARCKSL1, MAPK3, SYK, SCIN, RAC2",0.180456064458131,0.090979145788844,FALSE
+"A549","Input","KEGG_FOCAL_ADHESION",0.36156,1.04,0.355,991,0.646,"COL5A2, COL4A1, COL5A1, COL4A2, CAV2, MYLK, ITGA3, ITGA5, ITGB1, ITGB5, AKT3, FLNB, LAMB1, PRKCG, ITGAV, FN1, SRC, ITGB3, SPP1, ZYX, FLNA, ACTN1, ACTN4, CAV1, PPP1R12A, PRKCB, PARVA, LAMA5, ILK, BAD, ITGA1, IGF1R, PARVB",0.449771646944906,0.189767482004916,FALSE
+"A549","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.77497,-2.21,0.0018,9658,0.229,"ALPI, ALPP, ALPG",2.74472749489669,0.640164517660112,TRUE
+"A549","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.46754,-1.34,0.133,8420,0.603,"GMPPA, ALDOB, FBP2, HK2, FPGT, FBP1, PFKFB2, PFKFB4, MPI, PFKL, HK1, GMDS, ALDOC",0.876148359032914,0.219682687859849,FALSE
+"A549","Input","KEGG_GALACTOSE_METABOLISM",-0.35035,-0.996,0.409,7649,0.733,"PFKM, GALK2, GALE, PGM1, HK2, GCK, PGM2, PFKL, HK1",0.388276691992658,0.134896025358872,FALSE
+"A549","Input","KEGG_GAP_JUNCTION",0.4356,1.29,0.153,1261,0.574,"GJA1, PLCB4, PRKCG, TUBB2B, LPAR1, SRC, TJP1, GNAI1, ITPR1, TUBA4A, PRKCB, ADCY3, ADCY8, GNAQ, PRKACA, PRKCA",0.815308569182401,0.241088107602027,FALSE
+"A549","Input","KEGG_GLIOMA",0.25313,0.746,0.82,1564,0.954,"CDKN1A, AKT3, PRKCG, MDM2, PRKCB, IGF1R, PRKCA, PIK3R2, CCND1",0.0861861476162833,0.0204516252959049,FALSE
+"A549","Input","KEGG_GLUTATHIONE_METABOLISM",-0.34838,-0.998,0.42,8014,0.741,"GGT7, GSTM1, OPLAH, GSTA2, RRM2, LAP3, GPX3, IDH2, GGCT, GSTM3, GPX6, GPX7, GSTM4",0.3767507096021,0.130181792020672,FALSE
+"A549","Input","KEGG_GLYCEROLIPID_METABOLISM",0.28138,0.839,0.651,491,0.86,"AKR1B1, ALDH2, ALDH1B1, PLPP1, PLPP3",0.186419011431808,0.0655015487564323,FALSE
+"A549","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.27319,-0.803,0.718,8081,0.831,"PEMT, ETNK1, PISD, MBOAT1, DGKH, DGKQ, PLA2G15, PLA2G12A, CHKB, LYPLA2, CDS1, PLA2G2A, PCYT2",0.1438755557577,0.080398976215889,FALSE
+"A549","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31233,0.918,0.471,564,0.772,"GLDC, PIPOX, GAMT",0.326979092871104,0.112382699664264,FALSE
+"A549","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.40878,-1.17,0.25,8234,0.745,"ALDH9A1, ACSS1, PGM1, DLAT, ALDOB, FBP2, HK2, FBP1, GCK, ALDH1A3, ADH4, ADH7, PGM2, PFKL, ACSS2, HK1, ADH1C, ALDOC",0.602059991327962,0.127843727251707,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.47409,-1.36,0.142,9330,0.609,"CSGALNACT1, UST",0.847711655616944,0.215382707367125,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.2526,0.741,0.804,2787,0.945,"NDST1, B3GALT6, EXTL2, B3GAT3",0.0947439512515487,0.0245681914907371,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.39167,-1.09,0.316,8587,0.724,"B4GALT3, ST3GAL2, ST3GAL1",0.500312917381596,0.140261433802853,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.25406,-0.724,0.815,7713,0.937,"IDS, GNS, SGSH, HEXB, HPSE",0.0888423912600234,0.0282604091122217,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.50834,-1.47,0.0712,8748,0.864,"HEXB, ST3GAL2, ST3GAL1",1.14752000636314,0.0634862575211067,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.6881,-1.98,0.0109,8748,0.244,"HEXB, NAGA, ST3GAL2, ST3GAL1",1.96257350205938,0.612610173661271,TRUE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.49259,-1.42,0.105,9433,0.628,"FUT3, ST3GAL4, B3GNT3",0.978810700930062,0.202040356262804,FALSE
+"A549","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.51744,1.52,0.0922,2983,0.408,"PIGB, PIGX, PIGG, PIGQ, PIGH, PIGO, PIGW, PIGN",1.03526907894637,0.38933983691012,FALSE
+"A549","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.51685,-1.47,0.0924,7465,0.864,"PGP, GLYCTK, MTHFD2L, ACO2, MDH1, HYI, AFMID",1.03432802877989,0.0634862575211067,FALSE
+"A549","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31728,-0.899,0.561,7470,0.771,"PTK2B, MAP2K3, MAPK10, MAP3K4, MAP2K2, RAF1, KRAS, NRAS, CALML3, PLCB2, MAPK14, PRKCD, PLCB1, MAP3K3, CACNA1F, CALM2, MAPK1, PLCB3, MAP2K7, PLA2G12A, MAPK3, PLA2G2A, MMP14, MAPK12",0.251037138743839,0.112945621949043,FALSE
+"A549","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.20165,-0.567,0.98,7757,1,"GSK3B, WNT5B, CSNK1A1",0.00877392430750515,0,FALSE
+"A549","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.50287,1.47,0.0958,911,0.451,"CD38, ITGA3, ITGA5, CD44, ITGB3, KITLG, CD59, ITGA1",1.01863449092146,0.345823458122039,FALSE
+"A549","Input","KEGG_HISTIDINE_METABOLISM",0.3877,1.16,0.225,316,0.6,"ALDH3A1, ALDH3B1, ALDH2, ALDH1B1",0.647817481888638,0.221848749616356,FALSE
+"A549","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.47319,1.4,0.101,2666,0.497,"RAD54L, BRCA2, EME1, MUS81, NBN, BLM, RAD54B, POLD4, POLD3, SSBP1, POLD1, TOP3A, RAD51C, POLD2",0.995678626217357,0.303643611266668,FALSE
+"A549","Input","KEGG_HUNTINGTONS_DISEASE",0.21392,0.642,0.916,3502,0.976,"TGM2, PLCB4, GPX1, ITPR1, POLR2D, AP2A2, GNAQ, HIP1, NDUFA2, BBC3, CLTA, SDHC, POLR2L, AP2M1, SDHA, POLR2I, AP2S1, SDHB, ATP5PF, SDHD, NDUFS6, POLR2E, SLC25A6, NDUFV3, POLR2G, UQCRFS1, CLTC, NDUFB2, NDUFA10, NDUFV1, NDUFA7, NDUFA5, SLC25A4, NDUFS1, AP2A1, BAX, COX6B1, DNAL1, DCTN1, NDUFB9, NDUFS5, NDUFB7, COX7A2L, VDAC1, AP2B1, NDUFS4, DCTN2, NDUFB3, HAP1",0.0381045263321496,0.0105501823333082,FALSE
+"A549","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.58381,1.77,0.0275,911,0.467,"TPM2, DES, TPM1, ITGA3, TGFB2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ATP2A2, TPM4, ITGA1",1.56066730616974,0.330683119433888,FALSE
+"A549","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.3942,-1.12,0.285,7200,0.701,"PIP5K1A, PIK3CD, TPI1, INPPL1, ISYNA1, ALDH6A1, PIK3C3, PIK3CA, PLCB2, PLCG2, ITPKA, PLCB1, ITPK1, PIK3CB, PIK3C2B, PI4KB, SYNJ1, INPP5B, IMPA2, PLCB3",0.54515513999149,0.154281982033341,FALSE
+"A549","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.32829,-0.952,0.467,7090,0.761,"MAPK9, SOS1, MAP2K1, PRKAA1, PTPN1, PIK3CD, SORBS1, MKNK1, RAPGEF1, MAPK10, PHKG2, MAP2K2, BRAF, EIF4EBP1, PRKAR1B, GSK3B, RAF1, PIK3R1, KRAS, NRAS, PRKCI, PIK3CA, CALML3, CBLB, GYS1, PRKAR2B, CRKL, PIK3CB, CALM2, AKT1, MAPK1, FBP2, HK2, FOXO1, FBP1, GCK, INPP5D, PRKCZ, PPP1R3D, MAPK3, PDPK1, CBL, HK1",0.330683119433888,0.118615343229427,FALSE
+"A549","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.39955,-1.14,0.271,6996,0.687,"IL15RA, IL6, CXCR4, TNFSF13B, ICOSLG",0.567030709125594,0.16304326294045,FALSE
+"A549","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.34543,-0.967,0.467,7571,0.762,"IL6, SPRED2, PIK3R1, LIFR, PIK3CA, CBLB, PTPN6, IFNAR1, STAT6, PIK3CB, SPRY4, AKT1, IRF9, STAT2, EPO, CBL, PRLR, SPRY1",0.330683119433888,0.1180450286604,FALSE
+"A549","Input","KEGG_LEISHMANIA_INFECTION",-0.40968,-1.16,0.244,8229,0.728,"MAPK14, PTPN6, NFKBIA, IRAK4, NFKB1, MAPK1, MARCKSL1, MAPK3, FOS, IL1A, MAPK12",0.612610173661271,0.137868620686963,FALSE
+"A549","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.47542,-1.33,0.144,7702,0.6,"RAC1, VAV2, ITGB2, CTNNB1, PIK3R1, CTNNA2, VAV1, OCLN, PIK3CA, ROCK1, AFDN, MAPK14, PLCG2, F11R, CTNNA1, RASSF5, VAV3, CXCR4, PIK3CB, ICAM1, ACTG1, ITGAL, CLDN11, CLDN3, MAPK12, CLDN7, RAC2, CLDN4, CLDN18",0.84163750790475,0.221848749616356,FALSE
+"A549","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.52094,1.55,0.0406,1107,0.442,"ALDH2, ALDH1B1, ALDH3A2",1.39147396642281,0.354577730650908,FALSE
+"A549","Input","KEGG_LONG_TERM_DEPRESSION",0.27085,0.791,0.722,1261,0.881,"PLCB4, PRKCG, PLA2G4A, GNAI1, ITPR1, PRKCB, GNA13, IGF1R, GNAQ, PRKCA",0.141462802430361,0.0550240915879521,FALSE
+"A549","Input","KEGG_LONG_TERM_POTENTIATION",0.28298,0.829,0.65,1261,0.833,"PLCB4, PRKCG, ITPR1, PPP1R12A, PRKCB, ADCY8, PPP3R1, GNAQ, PRKACA, PRKCA",0.187086643357144,0.0793549985932124,FALSE
+"A549","Input","KEGG_LYSINE_DEGRADATION",0.36706,1.1,0.299,316,0.599,"PLOD2, PIPOX, ALDH2, ALDH1B1",0.52432881167557,0.222573177610689,FALSE
+"A549","Input","KEGG_LYSOSOME",-0.40736,-1.18,0.239,7182,0.742,"MAN2B1, AP3M2, NEU1, PPT2, SUMF1, TCIRG1, ATP6V0C, ATP6V0D1, SMPD1, IGF2R, IDS, GNS, ATP6V0A1, AP1S1, SGSH, SCARB2, GGA2, NPC2, ATP6AP1, CTSH, SLC11A2, CTSK, CTSO, LIPA, PPT1, HEXB, SLC17A5, DNASE2, SORT1, GGA1, ATP6V1H, FUCA1, AP1B1, PLA2G15, CLN5, NAGA, GM2A, LAMP1, CTSC, AP1M2, CTSE, MANBA, LAMP3, LAPTM5",0.621602099051862,0.129596094720973,FALSE
+"A549","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.23817,-0.679,0.883,8501,0.995,"MAPKAPK2, MAP3K5, CRKL, MAP3K3, PAK1, CACNA1F, DUSP10, CASP3, ARRB1, RPS6KA4, NFKB1, AKT1, MAPK1, RPS6KA5, MAPT, LAMTOR3, STMN1, MAPKAPK3, MAP4K2, MAP2K7, FGFR2, PLA2G12A, MAPK3, FOS, RPS6KA1, NFATC2, PLA2G2A, IL1A, MECOM, MAPK12, RAC2",0.0540392964224314,0.00217691925427455,FALSE
+"A549","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.3633,-1.05,0.357,8892,0.714,"HES1, GCK, IAPP",0.447331783887807,0.146301788223826,FALSE
+"A549","Input","KEGG_MELANOGENESIS",0.33522,0.986,0.394,1261,0.707,"FZD2, PLCB4, PRKCG, GNAI1, PRKCB, FZD7, KITLG, ADCY3, ADCY8, MITF, GNAQ, PRKACA, PRKCA",0.404503778174426,0.150580586203101,FALSE
+"A549","Input","KEGG_MELANOMA",0.43539,1.29,0.167,977,0.574,"FGF13, FGF2, CDKN1A, AKT3, MDM2, BAD, MITF, IGF1R",0.777283528852417,0.241088107602027,FALSE
+"A549","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41251,1.24,0.188,318,0.614,"AKR1C2, ALDH3A1, AKR1C1, ALDH3B1, AKR1C3, CYP2S1",0.72584215073632,0.211831628858832,FALSE
+"A549","Input","KEGG_MISMATCH_REPAIR",-0.21391,-0.609,0.942,2094,0.99,"PMS2, POLD4, POLD3, SSBP1, MSH6, POLD1, POLD2, MSH3, MSH2, MLH1, RPA1, PCNA, RPA2, RFC1, RPA3, RFC2, RFC5, RFC4, RFC3, LIG1, EXO1",0.0259490972071227,0.00436480540245009,FALSE
+"A549","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38951,-1.11,0.306,7644,0.693,"BRAF, EIF4EBP1, PIK3R1, PIK3CA, CAB39L, PIK3CB, AKT1, MAPK1, CAB39, MAPK3, PDPK1, RPS6KA1, STK11",0.51427857351842,0.159266765388193,FALSE
+"A549","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.43024,-1.22,0.215,7636,0.686,"MAP2K2, BRAF, RAC1, VAV2, RAF1, ITGB2, PIK3R1, MICA, KRAS, NRAS, VAV1, PIK3CA, PLCG2, PTPN6, IFNAR1, VAV3, RAET1L, ULBP2, PAK1, PIK3CB, ICAM1, CASP3, MAPK1, SH3BP2, MAPK3, LCK, ITGAL, SYK, NFATC2, RAC2",0.667561540084395,0.163675884293248,FALSE
+"A549","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.29375,-0.835,0.651,9000,0.815,"PRSS2, HCRTR1, TSPO, PRLR",0.186419011431808,0.0888423912600234,FALSE
+"A549","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.44965,-1.32,0.147,7498,0.598,"RAP1B, RAPGEF1, NFKBIE, MAPK10, MAP2K2, BRAF, RAC1, GSK3B, RAF1, ARHGDIA, PIK3R1, KRAS, NRAS, FRS2, PIK3CA, CALML3, MAPK14, PLCG2, NFKBIA, PRKCD, IRAK4, MAPKAPK2, MAP3K5, CRKL, MAP3K3, NGFR, PIK3CB, CALM2, RPS6KA4, NFKB1, AKT1, MAPK1, RPS6KA5, SORT1, MAP2K7, MAPK3, PDPK1, ARHGDIB, RPS6KA1, BCL2, MAPK12",0.832682665251824,0.223298816011589,FALSE
+"A549","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.45827,1.34,0.118,163,0.537,"NNMT, CD38, BST1",0.928117992693875,0.270025714300444,FALSE
+"A549","Input","KEGG_NITROGEN_METABOLISM",0.40232,1.18,0.257,667,0.604,"CPS1, GLUD2, CA12, CA8, GLS, GLS2",0.590066876668705,0.218963061378868,FALSE
+"A549","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.59547,-1.7,0.0336,8767,0.542,"NFKB1, MAPK1, MAPK3, CASP1, MAPK12, CASP5",1.47366072261016,0.266000713461613,FALSE
+"A549","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.40184,1.2,0.217,2300,0.614,"PRKDC, POLL, DCLRE1C, LIG4",0.66354026615147,0.211831628858832,FALSE
+"A549","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.32196,-0.921,0.51,7112,0.786,"SOS1, MAP2K1, PIK3CD, RXRA, RXRB, MAP2K2, BRAF, RASSF1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PLCG2, RASSF5, E2F1, PIK3CB, AKT1, MAPK1, CDKN2A, ERBB2, MAPK3, PDPK1",0.292429823902064,0.104577453960592,FALSE
+"A549","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.35897,1.08,0.302,734,0.62,"JAG1, NUMBL, JAG2, NCOR2, DTX2",0.519993057042849,0.207608310501746,FALSE
+"A549","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.32436,0.983,0.44,3620,0.696,"DDB2, ERCC8, XPC, CETN2, POLE3, ERCC1, POLE4, POLD4, GTF2H1, POLD3, GTF2H5, POLD1, CCNH, POLD2, GTF2H2, ERCC2, MNAT1, CDK7, GTF2H3, CUL4B, GTF2H4, XPA, RPA1, POLE2, ERCC3",0.356547323513813,0.157390760389438,FALSE
+"A549","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.22791,-0.647,0.929,7192,1,"MGAT1, ALG9, STT3A, ALG6, ALG11, MGAT3, MGAT5, B4GALT3, MGAT4B, MAN1A1, ST6GAL1",0.0319842860063582,0,FALSE
+"A549","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.40274,-1.16,0.263,8145,0.728,"CALML3, CALM2, PRKG2, CLCA2",0.580044251510242,0.137868620686963,FALSE
+"A549","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.36659,-1.02,0.37,6727,0.718,"GART, MTR, SHMT1, DHFR, MTHFD2L, MTHFR, AMT, TYMS, ALDH1L1",0.431798275933005,0.1438755557577,FALSE
+"A549","Input","KEGG_OOCYTE_MEIOSIS",-0.26978,-0.77,0.738,7793,0.876,"PPP2R5B, CDK2, AURKA, CCNB1, MOS, CALML3, SMC1A, SMC3, CALM2, PPP2R1B, PLK1, CDK1, MAPK1, PPP2R5A, PTTG1, MAPK3, RPS6KA1, MAPK12",0.131943638176958,0.0574958938319193,FALSE
+"A549","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.43545,-1.22,0.205,6677,0.686,"AGA, GBA, MAN2B1, NEU1, MAN2B2, FUCA2, HEXB, FUCA1, MANBA",0.688246138944246,0.163675884293248,FALSE
+"A549","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.21682,-0.626,0.934,6657,1,"COX6C, NDUFB5, NDUFB1, ATP5F1C, CYC1, ATP5PB, COX7A2, ATP5MG, TCIRG1, ATP6V0C, ATP6V0D1, PPA2, ATP6V0A1, PPA1, ATP6AP1, ATP6V1C1, ATP6V1E1, ATP6V1B2, ATP6V1F, COX7C, ATP6V1A, ATP12A, ATP6V1H, ATP6V1D, ATP6V1B1, ATP6V1G1",0.0296531237699066,0,FALSE
+"A549","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.36079,-1.03,0.376,8426,0.733,"GALNT5, GALNT12, ST6GALNAC1, ST3GAL2, GCNT1, ST3GAL1, GALNT6, GALNT3",0.424812155072339,0.134896025358872,FALSE
+"A549","Input","KEGG_P53_SIGNALING_PATHWAY",0.28525,0.867,0.635,542,0.834,"TP53I3, CDKN1A, SERPINE1, MDM2, ZMAT3, CCNB3, DDB2",0.197226274708024,0.0788339493622613,FALSE
+"A549","Input","KEGG_PANCREATIC_CANCER",-0.31114,-0.89,0.567,7566,0.77,"MAPK10, BRAF, RAC1, RAF1, PIK3R1, RALBP1, KRAS, PIK3CA, RALA, E2F1, PIK3CB, ARHGEF6, NFKB1, AKT1, MAPK1, CDKN2A, ERBB2, RAD51, MAPK3, RAC2",0.246416941107093,0.113509274827518,FALSE
+"A549","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.3068,-0.878,0.584,7354,0.775,"COASY, PANK3, PANK4, PPCS",0.233587152887601,0.11069829749369,FALSE
+"A549","Input","KEGG_PARKINSONS_DISEASE",-0.13765,-0.395,1,8618,1,"COX7C, CASP3, SNCA, UBE2L6, UBA7",0,0,FALSE
+"A549","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.22644,0.67,0.925,1500,0.975,"ITGB1, TUBB2B, TUBA4A, YWHAQ, PRKCA, CD14, TUBB6, ACTB",0.0338582672609674,0.0109953843014632,FALSE
+"A549","Input","KEGG_PATHWAYS_IN_CANCER",0.29415,0.862,0.605,1020,0.828,"FGF13, FGF2, COL4A1, FZD2, CDKN1A, COL4A2, ITGA3, TGFB2, ITGB1, AKT3, LAMB1, PRKCG, ITGAV, FN1, MDM2, DAPK3, TGFBR2, AR, DAPK1, PRKCB, TGFBR1, FZD7, KITLG, LAMA5, EGLN1, BAD, SUFU, MITF, IGF1R, SMAD3, BCL2L1",0.218244625347531,0.0819696632151199,FALSE
+"A549","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39768,1.21,0.188,747,0.619,"AKR1B1, UGDH",0.72584215073632,0.208309350979882,FALSE
+"A549","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.44452,-1.26,0.177,8377,0.709,"PGM1, ALDOB, PGLS, FBP2, FBP1, PGM2, PFKL, ALDOC",0.752026733638193,0.149353764816933,FALSE
+"A549","Input","KEGG_PEROXISOME",-0.22017,-0.624,0.941,8477,1,"FAR2, FAR1, PXMP4, PMVK, ACSL1, ABCD1, IDH2, ACSL5, NUDT12, DDO",0.0264103765727431,0,FALSE
+"A549","Input","KEGG_PHENYLALANINE_METABOLISM",0.41027,1.21,0.222,222,0.619,"ALDH3A1, ALDH3B1",0.653647025549361,0.208309350979882,FALSE
+"A549","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.34104,-0.966,0.429,8099,0.753,"PIK3C3, PIK3CA, CALML3, PLCB2, PLCG2, ITPKA, PLCB1, ITPK1, PIK3CB, DGKH, CALM2, PIK3C2B, PI4KB, SYNJ1, INPP5B, IMPA2, DGKQ, PLCB3, INPP5D, CDS1",0.367542707815276,0.123205023799299,FALSE
+"A549","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.28214,0.833,0.667,1831,0.841,"HMOX1, COX15, CPOX, FECH, HCCS",0.175874166083451,0.0752040042020878,FALSE
+"A549","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.47291,-1.38,0.132,8533,0.593,"ACADM, FABP1, FABP2, ACSL1, SCD, CYP27A1, CPT2, DBI, GK, PDPK1, HMGCS2, FABP6, ACSL5, PLTP, LPL",0.87942606879415,0.226945306635737,FALSE
+"A549","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.316,-0.899,0.541,7958,0.771,"TAP2, BTK, PTPRC, LCK",0.266802734893431,0.112945621949043,FALSE
+"A549","Input","KEGG_PRION_DISEASES",-0.32726,-0.949,0.485,8788,0.757,"MAPK1, MAPK3, NCAM1, IL1A",0.314258261397736,0.120904120499927,FALSE
+"A549","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.29023,-0.833,0.638,7090,0.801,"MAPK9, MAP2K1, HSP90AB1, PIK3CD, GNAI2, PKMYT1, CCNA2, MAPK10, BRAF, RAF1, CDK2, PIK3R1, CCNB1, KRAS, PIK3CA, MOS, MAPK14, PIK3CB, FZR1, PLK1, CDK1, AKT1, MAPK1, MAPK3, RPS6KA1, MAPK12",0.195179321278838,0.0963674839157623,FALSE
+"A549","Input","KEGG_PROPANOATE_METABOLISM",-0.32193,-0.904,0.543,7870,0.791,"PCCA, ACSS3, ALDH6A1, ALDH9A1, ACSS1, ACADM, ACAT2, ABAT, ACSS2",0.265200170411153,0.101823516502323,FALSE
+"A549","Input","KEGG_PROSTATE_CANCER",-0.32041,-0.915,0.535,7112,0.779,"SOS1, MAP2K1, HSP90AB1, CREB5, PIK3CD, GSTP1, MAP2K2, BRAF, GSK3B, RAF1, CDK2, CTNNB1, PIK3R1, CREB3L2, KRAS, NRAS, PIK3CA, PDGFC, NFKBIA, E2F1, PIK3CB, NFKB1, AKT1, MAPK1, ERBB2, FOXO1, FGFR2, MAPK3, PDPK1, BCL2",0.271646217978772,0.108462542327436,FALSE
+"A549","Input","KEGG_PROTEASOME",-0.36966,-1.04,0.379,9089,0.723,"PSME2, PSME1, PSMB8, PSMB10",0.421360790031928,0.140861702705469,FALSE
+"A549","Input","KEGG_PROTEIN_EXPORT",0.18109,0.529,0.991,479,0.991,"SEC61A2",0.00392634551472468,0.00392634551472468,FALSE
+"A549","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.4405,-1.24,0.208,7927,0.708,"ATP1B1, MDH1, ATP1A1, ATP1A4, ATP1A3, ATP1B3, SLC38A3, CA2",0.681936665037238,0.149966742310231,FALSE
+"A549","Input","KEGG_PURINE_METABOLISM",0.24822,0.708,0.855,2719,0.937,"NME4, PDE4D, PAPSS2, ADA, POLR2D, PFAS, ADCY3, ADCY8, NPR2, POLR1E, PDE6C, NT5C, PDE8A, POLE3, POLE4, PKM, ENPP1, POLR2L, PRPS1, PRPS1L1, POLR3H, RRM2B, POLR2I, PDE1C, PDE8B, POLR3D, POLA2, POLD4, POLD3, AK4, PKLR, POLD1, POLR2E, NME2, NME1, POLA1, POLR2G, PRIM2, PNPT1, POLD2, PRIM1",0.0680338852718274,0.0282604091122217,FALSE
+"A549","Input","KEGG_PYRIMIDINE_METABOLISM",0.23836,0.719,0.854,2719,0.95,"NME4, CTPS1, POLR2D, CDA, POLR1E, NT5C, TXNRD1, POLE3, POLE4, POLR2L, POLR3H, RRM2B, POLR2I, POLR3D, POLA2, POLD4, POLD3, CAD, POLD1, POLR2E, NME2, NME1, POLA1, POLR2G, PRIM2, PNPT1, POLD2, PRIM1",0.068542129310995,0.0222763947111523,FALSE
+"A549","Input","KEGG_PYRUVATE_METABOLISM",0.28395,0.837,0.636,2381,0.848,"AKR1B1, ALDH2, ALDH1B1, ME3, ALDH3A2, PKM, HAGH, GRHPR, ME2, ALDH7A1, LDHA, PC, PKLR",0.196542884351586,0.0716041477432862,FALSE
+"A549","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.24462,0.737,0.802,911,0.936,"FGF13, FGF2, MYLK, ITGA3, ITGA5, ITGB1, ITGB5, ITGAV, FN1, ITGB3, RDX, ACTN1, ACTN4, CFL2, PPP1R12A, MSN, RRAS, ARHGEF4, GNA13, ITGA1",0.0958256317158365,0.0287241512618947,FALSE
+"A549","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.40139,-1.15,0.26,6945,0.716,"ATG7, PIK3R4, BECN1, PRKAA1, ATG4A, PIK3C3, GABARAPL1, GABARAPL2",0.585026652029182,0.145086977692144,FALSE
+"A549","Input","KEGG_RENAL_CELL_CARCINOMA",-0.34015,-0.982,0.413,7111,0.74,"HGF, SOS1, MAP2K1, PIK3CD, RAP1B, RAPGEF1, MAP2K2, BRAF, RAC1, PAK2, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PAK3, CRKL, PAK1, PIK3CB, FLCN, AKT1, MAPK1, MAPK3, PAK5, PAK6",0.384049948343599,0.130768280269024,FALSE
+"A549","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32666,0.963,0.431,717,0.723,"ENPEP, NLN",0.365522729839268,0.140861702705469,FALSE
+"A549","Input","KEGG_RETINOL_METABOLISM",0.37317,1.07,0.328,1303,0.605,"ALDH1A1, ALDH1A2, DHRS3, RETSAT, RDH10",0.484126156288321,0.218244625347531,FALSE
+"A549","Input","KEGG_RIBOFLAVIN_METABOLISM",0.4058,1.18,0.221,1653,0.604,"RFK, ENPP1",0.655607726314889,0.218963061378868,FALSE
+"A549","Input","KEGG_RIBOSOME",0.57171,1.7,0.0498,3500,0.358,"RPS4Y1, RPL22L1, RPL35, RPL36, RPS6, RPL32, RPL18, RPLP2, RPL24, RSL24D1, RPS24, RPL28, RPS8, RPS12, RPL7A, RPL26, RPL18A, RPL13A, RPSA, RPL17, RPL36A, RPL36AL, RPL35A, RPL6, RPL23A, RPL9, RPL27A, RPL31, RPL21, RPL23, RPL22, RPS3A, RPS26, RPL12, RPL34, RPL37A, RPS28, RPL10A, RPL4, RPL3, RPS2, RPL7, FAU, RPL29, RPS18, RPL27, RPS4X, RPS29, RPL5, RPL11, RPS15A, RPL14, RPL30, MRPL13, RPL13, RPL8, RPS9, RPS15, RPS3, RPS17, RPLP0, RPS23",1.30277065724028,0.446116973356126,FALSE
+"A549","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.34822,-0.99,0.438,8229,0.734,"MAPK14, NFKBIA, FADD, SIKE1, NFKB1, IFIH1, DDX58, DHX58, ISG15, MAPK12",0.3585258894959,0.134303940083929,FALSE
+"A549","Input","KEGG_RNA_DEGRADATION",0.36616,1.07,0.319,2448,0.605,"TENT4A, PARN, ZCCHC7, MPHOSPH6, TTC37, EXOSC1, C1D, ENO3, SKIV2L, XRN2, EXOSC8, PAPOLG, EXOSC5, EXOSC10, MTREX, EXOSC9, EXOSC4, EXOSC3, DCP1B, EXOSC7, EXOSC6",0.496209316942819,0.218244625347531,FALSE
+"A549","Input","KEGG_RNA_POLYMERASE",0.51095,1.53,0.0747,4124,0.43,"POLR2D, POLR1E, POLR2L, POLR3H, POLR2I, POLR3D, POLR2E, POLR2G, POLR3A, POLR3C, POLR3G, POLR1A, POLR3GL, POLR3F, POLR3K, POLR3B",1.1266793981846,0.366531544420413,FALSE
+"A549","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.27573,0.813,0.677,1692,0.852,"GGT1, PAPSS2, MAT2A, MAT1A, GGT5",0.169411331314856,0.0695604052332999,FALSE
+"A549","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.35319,1.02,0.376,376,0.67,"COL4A1, COL4A2, ITGA3, ITGB1, AKT3, LAMB1, ITGAV, FN1",0.424812155072339,0.173925197299174,FALSE
+"A549","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.29286,-0.834,0.626,7613,0.808,"STX6, STX18, SNAP23, STX16, SEC22B, SNAP47, STX12, STX7, SNAP29, VAMP4, YKT6, VAMP8, STX3, VAMP5",0.20342566678957,0.0925886392254138,FALSE
+"A549","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.29964,-0.851,0.608,9645,0.81,"SMPD3, UGT8",0.216096420727265,0.0915149811213502,FALSE
+"A549","Input","KEGG_SPLICEOSOME",0.21371,0.634,0.955,6295,0.969,"HSPA2, HSPA1L, DDX42, TRA2A, SNRPD3, SNRPB, U2AF1, DDX46, SRSF9, DDX23, SNRPG, PUF60, SF3B5, U2AF2, SNU13, THOC1, DDX5, SNRPF, HNRNPA1, RBMX, SRSF7, THOC3, SNRNP70, SF3A1, HNRNPC, SNRPC, SF3B6, SF3A2, SRSF2, SNRPA, SMNDC1, SNRPD1, SNRPD2, SF3A3, THOC2, CHERP, SF3B1, PRPF8, SRSF3, SRSF8, EFTUD2, DDX39B, HSPA6, HNRNPA3, SRSF1, TCERG1, LSM2, PHF5A, TRA2B, NCBP2, PPIL1, SNRPE, NCBP1, SNW1, SRSF4, PRPF3, HSPA8, ALYREF, SNRNP40, SRSF10, USP39, HNRNPK, RBM22, RBM17, PRPF40A, SF3B4, CDC5L, SNRNP200, RBM25, PLRG1, PRPF19, HSPA1A, DHX38, PQBP1, SF3B2, PRPF31, CRNKL1, CTNNBL1, HNRNPM, TXNL4A, PRPF4, RBM8A, ZMAT2, U2SURP, SNRPA1, ACIN1, SF3B3, BCAS2, LSM4, XAB2, DHX8, AQR, SNRPB2, CCDC12, WBP11, PRPF40B, SRSF5, EIF4A3, LSM3, SART1, SLU7, LSM7, ISY1, LSM8, PCBP1, PRPF38B, DHX15, SRSF6, DHX16, PRPF6, SYF2, PPIH, LSM6",0.0199966284162537,0.0136762229492347,FALSE
+"A549","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.40793,-1.19,0.228,8377,0.739,"PGM1, GYS1, UGT2B17, AGL, HK2, GCK, PGM2, HK1",0.642065152999546,0.131355561605174,FALSE
+"A549","Input","KEGG_STEROID_BIOSYNTHESIS",-0.72831,-2.11,0.00358,8256,0.226,"HSD17B7, CEL, LIPA, MSMO1, SOAT2, DHCR7, FDFT1, CYP27B1, SC5D, DHCR24",2.44611697335613,0.645891560852599,TRUE
+"A549","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.37622,-1.08,0.315,9676,0.731,"HSD11B2, SULT1E1, HSD17B2",0.501689446210399,0.13608262304214,FALSE
+"A549","Input","KEGG_SULFUR_METABOLISM",-0.6033,-1.75,0.0237,9422,0.513,"BPNT1, SULT1E1",1.6252516539899,0.289882634888184,FALSE
+"A549","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.72897,2.18,0.00685,1814,0.199,"C1S, C9, ACTN1, ACTN4, C1R, CD40, C4A, SNRPD3, SNRPB",2.16430942850757,0.701146923590293,TRUE
+"A549","Input","KEGG_TASTE_TRANSDUCTION",-0.433,-1.25,0.182,9776,0.707,"SCNN1A",0.739928612014925,0.150580586203101,FALSE
+"A549","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.72157,-2.03,0.0107,8203,0.243,"MVK, GGPS1, PMVK, IDI1, ACAT2, MVD, HMGCR, FDPS, HMGCS2",1.97061622231479,0.614393726401688,TRUE
+"A549","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.29945,0.888,0.56,1868,0.805,"TGFB2, TGFBR2, TGFBR1, ACVR1, SMAD3, SMAD2, ID1, ZFYVE16, SMURF2, ROCK2, INHBA",0.2518119729938,0.0942041196321315,FALSE
+"A549","Input","KEGG_THYROID_CANCER",-0.50713,-1.45,0.104,6880,0.682,"TCF7L2, MAP2K1, CCDC6, RXRA, RXRB, MAP2K2, BRAF, CTNNB1, NCOA4, KRAS, NRAS, CDH1, MAPK1, MAPK3",0.98296666070122,0.166215625343521,FALSE
+"A549","Input","KEGG_TIGHT_JUNCTION",-0.403,-1.15,0.263,8041,0.716,"KRAS, NRAS, OCLN, PRKCI, PARD6A, AFDN, F11R, CTNNA1, PRKCD, TJAP1, PPP2R1B, AKT1, MYH7, EPB41, PATJ, ACTG1, PRKCZ, EPB41L3, MYH14, MYH7B, HCLS1, TJP3, CRB3, CGN, CLDN11, TJP2, CLDN3, CLDN7, CLDN4, CLDN18",0.580044251510242,0.145086977692144,FALSE
+"A549","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.44005,-1.23,0.224,7315,0.708,"PIK3CD, TLR2, RIPK1, MYD88, MAP2K3, MAPK10, IL6, MAP2K2, RAC1, MAP3K7, PIK3R1, PIK3CA, MAPK14, IFNAR1, NFKBIA, IRAK4, FADD, PIK3CB, CTSK, NFKB1, AKT1, MAPK1, MAP2K7, MAPK3, FOS, TLR3, MAPK12",0.649751981665837,0.149966742310231,FALSE
+"A549","Input","KEGG_TRYPTOPHAN_METABOLISM",0.31298,0.922,0.502,316,0.78,"KYNU, ALDH2, ALDH1B1",0.299296282854981,0.10790539730952,FALSE
+"A549","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.29933,-0.877,0.585,7090,0.768,"MAPK9, PDX1, PIK3CD, MAPK10, PIK3R1, PIK3CA, PRKCD, PIK3CB, MAPK1, HK2, GCK, PRKCZ, MAPK3, HK1",0.23284413391782,0.114638779968488,FALSE
+"A549","Input","KEGG_TYROSINE_METABOLISM",-0.47428,-1.41,0.111,8581,0.557,"LCMT1, MAOB, IL4I1, MIF, ALDH1A3, MAOA, ADH4, ADH7, ADH1C",0.954677021213343,0.254144804826271,FALSE
+"A549","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.51039,-1.46,0.0882,7558,0.76,"NFKBIE, MAP2K2, PAK2, VAV2, GSK3B, RAF1, MAP3K7, PIK3R1, DLG1, KRAS, NRAS, VAV1, PTPRC, PIK3CA, PAK3, MAPK14, NCK2, CBLB, PTPN6, BCL10, NFKBIA, VAV3, PAK1, PIK3CB, NFKB1, AKT1, MAPK1, MAP2K7, MAPK3, PDPK1, CBL, FOS, LCK, PAK5, PAK6, CARD11, NFATC2, MAPK12",1.05453141486818,0.119186407719209,FALSE
+"A549","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.21024,-0.609,0.964,7832,0.99,"UBE2Q1, UBE2NL, UBE3A, UBE2L3, UBE4A, CUL7, UBE2D4, FBXO2, UBE2B, CBLB, PML, UBE2K, WWP2, FZR1, UBA6, UBE2C, CBL, RCHY1, UBE2L6, KEAP1, UBA7",0.0159229660971692,0.00436480540245009,FALSE
+"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.30756,0.915,0.546,6795,0.762,"BCAT2, PDHA1, PDHB, IARS2, BCAT1, VARS2, LARS2",0.262807357295263,0.1180450286604,FALSE
+"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.37201,-1.07,0.337,6530,0.697,"EHHADH, BCAT1, BCKDHB, HMGCL, HADH, HADHA, PCCB, HMGCS1, DLD, MCCC2, PCCA, ALDH6A1, DBT, ALDH9A1, ACAD8, ACADM, ACAT2, IL4I1, IVD, MCCC1, ABAT, HMGCS2, OXCT1",0.472370099128661,0.156767221901991,FALSE
+"A549","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.47889,1.42,0.0958,1975,0.496,"PPP1R14A, CALD1, MYLK, PLCB4, KCNMA1, PRKCG, PLA2G4A, ITPR1, PPP1R12A, PRKCB, PRKCH, PPP1R12B, ADCY3, ADCY8, GNA13, PRKCQ, PRKCE, NPR2, MYL6, GNAQ, PRKACA, PRKCA, MYL6B, MYH11, ACTA2, ARHGEF1, ROCK2, MYL9, GNA12, PPP1CB",1.01863449092146,0.304518323509803,FALSE
+"A549","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.17061,-0.499,0.995,7555,1,"AQP3, ARHGDIA, CREB3L2, AVP, RAB11B, ARHGDIB",0.00217691925427455,0,FALSE
+"A549","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.3919,-1.11,0.265,7636,0.693,"MAP2K2, RAC1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, MAPK14, PLCG2, SPHK1, MAPKAPK2, PIK3CB, AKT1, MAPK1, MAPKAPK3, PLA2G12A, MAPK3, NFATC2, PLA2G2A, MAPK12, RAC2",0.576754126063192,0.159266765388193,FALSE
+"A549","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.33882,-0.947,0.475,8257,0.75,"PLCG2, ATP6AP1, ATP6V1C1, ATP6V1E1, ATP6V1B2, ATP6V1F, ERO1A, ATP6V1A, ATP6V1H, ATP6V1D, ACTG1, ATP6V1B1, ATP6V1G1, TJP2",0.323306390375133,0.1249387366083,FALSE
+"A549","Input","KEGG_VIRAL_MYOCARDITIS",-0.39183,-1.14,0.254,8578,0.687,"ICAM1, CASP3, MYH7, ACTG1, MYH14, MYH7B, ITGAL, RAC2",0.595166283380062,0.16304326294045,FALSE
+"A549","Input","KEGG_WNT_SIGNALING_PATHWAY",0.21665,0.655,0.956,1261,0.978,"FZD2, PLCB4, PRKCG, DKK1, NKD2, LRP6, MMP7, PRKCB, FZD7, SMAD3, PPP3R1, SMAD2, PRKACA, PRKCA",0.0195421077238999,0.00966114521239857,FALSE
+"HCC15","Input","KEGG_ABC_TRANSPORTERS",0.70761,2.25,0.00644,705,0.102,"ABCC2, ABCC3, ABCG2, ABCD1, ABCA3, ABCC1, ABCA13, TAP2, ABCB6",2.19111413264019,0.991399828238082,TRUE
+"HCC15","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.34599,-1.06,0.35,7526,0.95,"NFKB1, CCND1, PIK3CD, PIK3CB, SOS1, RUNX1, TCF7L1, RAF1, PIK3R2, RUNX1T1, CEBPA, AKT3, PIK3CG, GRB2, SPI1, EIF4EBP1",0.455931955649724,0.0222763947111523,FALSE
+"HCC15","Input","KEGG_ADHERENS_JUNCTION",0.32027,1,0.382,926,0.57,"TJP1, PTPRJ, TGFBR2, EGFR, PTPRB, ACTN4, CDH1, IQGAP1, CTNNB1, CTNND1, CTNNA2, CTNNA1, PTPN1, NECTIN2",0.417936637088291,0.244125144327509,FALSE
+"HCC15","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.48884,1.51,0.0788,2462,0.295,"SLC2A1, ACSL3, LEPR, IRS1, PRKAG1, AKT1, ACACB, CHUK, PRKAA1, MAPK8, ACSL1, STK11, PRKAG2, ADIPOR1, MAPK9, PRKAB1, CPT1A, NFKBIB, AKT2, MAPK10, TRAF2, TNFRSF1A, ACSL6",1.10347378251044,0.530177984021837,FALSE
+"HCC15","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39279,1.23,0.203,1685,0.41,"ASS1, CPS1, GPT, GLUD1, GOT1, ALDH4A1, GFPT1, PPAT, ALDH5A1, GOT2",0.692503962086787,0.387216143280265,FALSE
+"HCC15","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.3622,1.16,0.241,478,0.456,"ATP1B1, PIK3R3, SLC9A3R2, IRS1, SFN",0.617982957425132,0.341035157335565,FALSE
+"HCC15","Input","KEGG_ALZHEIMERS_DISEASE",-0.20356,-0.641,0.927,8137,1,"IL1B, UQCRC2, NDUFS4, UQCR10, APP, GSK3B, PLCB2, LRP1, GRIN1, UQCRB, APOE, MME, UQCRFS1, UQCRQ, ATP2A3, LPL, ATP2A1, SNCA",0.0329202658555029,0,FALSE
+"HCC15","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.376,1.18,0.244,2253,0.438,"IARS2, RARS2, SARS2, MARS2, YARS2, NARS2, MTFMT, EARS2, DARS2, FARSB",0.612610173661271,0.3585258894959,FALSE
+"HCC15","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.30031,0.939,0.472,1513,0.602,"UGDH, GNPNAT1, HEXA, PGM3, GNPDA2, PMM2, GALE, GFPT1",0.326058001365912,0.220403508742175,FALSE
+"HCC15","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.343,1.06,0.346,2652,0.515,"MAPK13, BCL2L1, APAF1, MAP2K6, RAB5A, TP53, DERL1, PRPH, PRPH2, PPP3CC, TNFRSF1A, CASP1, TOMM40, BAD, CAT",0.460923901207223,0.288192770958809,FALSE
+"HCC15","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.3367,1.04,0.378,1309,0.533,"B2M, HSPA1L, HSPA2, CTSL, TAP2, LGMN, HSPA6, TAPBP, PSME2, HSPA1A",0.422508200162775,0.273272790973428,FALSE
+"HCC15","Input","KEGG_APOPTOSIS",0.29657,0.934,0.474,1161,0.604,"IL1A, TNFRSF10A, BCL2L1, CAPN2, PIK3R3, CAPN1, AKT1, ENDOD1, CHUK, ATM, BIRC2, APAF1, CASP7",0.324221658325915,0.218963061378868,FALSE
+"HCC15","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.57412,1.8,0.0224,746,0.289,"AKR1C3, GGT1, LTA4H, PTGES, CBR3, CBR1, PTGS2",1.64975198166584,0.539102157243452,FALSE
+"HCC15","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.27417,0.882,0.58,1685,0.667,"ASS1, ODC1, ALDH2, CPS1, MAOA, ALDH3A2, ALDH7A1, GLUD1, GAMT, GOT1, ALDH4A1, ALDH9A1, SAT2, GOT2",0.236572006437063,0.175874166083451,FALSE
+"HCC15","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.45423,1.45,0.0876,897,0.286,"ITGA1, PKP2, ITGB5, ACTN4, ITGB4, DMD, CDH2, ITGA6, ITGA3, ITGA2, CTNNB1, DES, CTNNA2, CACNA1C, CTNNA1, LMNA",1.05749589383192,0.543633966870957,FALSE
+"HCC15","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.7467,2.33,0,1421,0.0792,"ALDH2, UGDH, ALDH3A2, ALDH7A1, ALDH9A1",Inf,1.10127481841051,TRUE
+"HCC15","Input","KEGG_AXON_GUIDANCE",-0.25068,-0.759,0.722,7564,1,"RGS3, ROCK1, RHOA, PLXNB1, NFATC4, EPHA1, NCK2, PAK3, PAK1, NFATC1, SEMA4A, GSK3B, RAC2, DPYSL5, L1CAM, NFATC2, ROBO1, FES, NTNG1, NCK1, RAC3, NTN4, UNC5B, SEMA7A, PLXNA1",0.141462802430361,0,FALSE
+"HCC15","Input","KEGG_BASAL_CELL_CARCINOMA",0.27273,0.849,0.613,2498,0.696,"FZD6, CTNNB1, APC, TP53, SMO, DVL2, AXIN1, STK36, BMP4",0.212539525481585,0.157390760389438,FALSE
+"HCC15","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36818,-1.12,0.294,6612,0.951,"TAF1, TAF9B, TAF10, TAF5, TAF6, GTF2F1, TAF9, TAF4, GTF2B, GTF2E1, GTF2E2, TAF12, GTF2F2, TAF7",0.531652669587843,0.0218194830625861,FALSE
+"HCC15","Input","KEGG_BASE_EXCISION_REPAIR",-0.28007,-0.869,0.582,7320,0.914,"APEX1, MBD4, PARP1, POLB, SMUG1, TDG, MPG, NEIL2",0.235077015350112,0.0390538042661686,FALSE
+"HCC15","Input","KEGG_BETA_ALANINE_METABOLISM",0.41599,1.3,0.164,1421,0.378,"ALDH2, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1",0.785156151952302,0.422508200162775,FALSE
+"HCC15","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.40036,-1.24,0.191,8886,0.77,"SCD, FADS2, ELOVL6, SCD5",0.718966632752272,0.113509274827518,FALSE
+"HCC15","Input","KEGG_BLADDER_CANCER",-0.32802,-1.01,0.391,8344,0.947,"E2F3, RAF1, CDK4, MDM2, MMP2, VEGFA, RB1, CDKN2A",0.407823242604133,0.0236500209967266,FALSE
+"HCC15","Input","KEGG_BUTANOATE_METABOLISM",0.32717,1.02,0.381,1602,0.55,"ALDH2, AACS, ACADS, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1, ALDH5A1",0.419075024324381,0.259637310505756,FALSE
+"HCC15","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.39899,-1.22,0.236,8272,0.774,"NFATC1, GSK3B, CD81, PLCG2, RAF1, BTK, RAC2, PIK3R2, PRKCB, AKT3, VAV3, NFATC2, CD79A, PIK3CG, GRB2, RAC3, PIK3AP1, FCGR2B, INPP5D, CD79B",0.627087997029893,0.111259039317107,FALSE
+"HCC15","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.336,-1.04,0.357,8465,0.932,"PLCG1, PLCG2, TNNC1, PLCB2, PRKCB, RYR1, GRIN1, MYLK, PDGFRB, PDE1C, ATP2A3, PLCZ1, ATP2A1, CAMK4, BST1, SLC8A1",0.447331783887807,0.0305840876460186,FALSE
+"HCC15","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.4178,-1.28,0.184,8212,0.964,"UQCRC2, CACNB3, UQCR10, ATP1B3, TNNC1, UQCRB, UQCRFS1, UQCRQ, TPM2, CACNA2D1, SLC8A1",0.735182176990464,0.0159229660971692,FALSE
+"HCC15","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.39663,1.22,0.212,926,0.416,"CLDN6, ICAM2, CD274, CADM1, CD40, OCLN, CDH1, CD99, CDH2, SDC4, CDH4, ITGA6, NEGR1, ICAM1, CLDN1, MPZ, MPZL1, NECTIN2",0.673664139071249,0.380906669373257,FALSE
+"HCC15","Input","KEGG_CELL_CYCLE",-0.27195,-0.827,0.641,7699,0.929,"PTTG1, CDKN1A, CDC20, CDKN1B, CREBBP, TFDP2, DBF4, GSK3B, E2F3, CHEK2, ZBTB17, E2F4, BUB1, CCND2, ORC6, CDK4, MDM2, SKP2, SMAD4, E2F5, TFDP1, RB1, EP300, CDKN2A",0.193141970481183,0.0319842860063582,FALSE
+"HCC15","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.17974,0.578,0.977,1425,0.972,"CXCL8, ARRB1, PIK3R3, STAT1, GNAI1, ADCY9, AKT1, ADCY5, ROCK2, GNG2, CCL13, RASGRP2, CHUK, GNG12, ADCY6, VAV2, SHC1",0.0101054362812269,0.0123337350737254,FALSE
+"HCC15","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.33954,-1.04,0.353,7526,0.932,"NFKB1, BCR, CCND1, PIK3CD, PIK3CB, CDKN1A, CTBP1, CDKN1B, SOS1, MECOM, RUNX1, E2F3, RAF1, PIK3R2, CDK4, MDM2, AKT3, SMAD4, PIK3CG, CBLB, GRB2, RB1, CDKN2A",0.452225294612177,0.0305840876460186,FALSE
+"HCC15","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.46598,1.49,0.0792,1738,0.295,"PC, IDH3G, OGDH, OGDHL, DLAT, CS, IDH3B, FH, IDH3A, SDHC",1.10127481841051,0.530177984021837,FALSE
+"HCC15","Input","KEGG_COLORECTAL_CANCER",-0.19612,-0.597,0.96,6493,1,"TGFB1, CASP3, TGFB2, CYCS, MAPK1, BRAF, PIK3R1, FOS, APPL1, CCND1, PIK3CD, PIK3CB, RHOA, BIRC5, GSK3B, TCF7L1, RAF1, RAC2, PIK3R2, AKT3, SMAD4, PIK3CG, RAC3",0.0177287669604316,0,FALSE
+"HCC15","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.41377,1.29,0.185,1274,0.367,"THBD, PLAUR, MBL2, F2R, C9, PLAU, CFH, SERPINA1, PROC, CD46, CD59, TFPI",0.732828271596986,0.435333935747911,FALSE
+"HCC15","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.29763,0.941,0.489,1685,0.606,"MAT1A, CBS, APIP, GOT1, SDS, LDHA, GOT2",0.31069114087638,0.217527375833714,FALSE
+"HCC15","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.47072,1.46,0.0985,890,0.292,"IL1A, TNFRSF12A, TNFRSF19, TNFRSF21, IFNGR1, IL18, TNFRSF10A, CXCL8, TGFBR2, EGFR, CD40, KIT, LEPR, BMPR1A, IL13RA1, BMPR2, OSMR, CCL13",1.00656376950239,0.534617148551582,FALSE
+"HCC15","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.34526,1.09,0.307,1168,0.505,"ZBP1, IL18, DDX58, CHUK, RIPK3, PYCARD",0.512861624522813,0.296708621881339,FALSE
+"HCC15","Input","KEGG_DILATED_CARDIOMYOPATHY",0.34044,1.08,0.337,897,0.491,"ITGA1, ITGB5, ITGB4, DMD, ITGA6, ITGA3, ITGA2, ADCY9, DES, ADCY5, CACNA1C, LMNA",0.472370099128661,0.308918507877032,FALSE
+"HCC15","Input","KEGG_DNA_REPLICATION",0.3924,1.25,0.188,3223,0.392,"POLD1, LIG1, MCM6, MCM5, MCM3, MCM7, RFC1, POLA1, MCM4, POLE4, POLD3, POLE2, FEN1, POLA2, SSBP1, POLE, PRIM1, MCM2, PRIM2",0.72584215073632,0.406713932979543,FALSE
+"HCC15","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.33996,1.08,0.29,201,0.491,"PIWIL1, EGFR",0.537602002101044,0.308918507877032,FALSE
+"HCC15","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.55855,1.74,0.0335,1069,0.221,"ALDH3A1, GSTM4, GSTM3, GSTM2, CYP3A7, MAOA, ALDH3B1, MGST1",1.47495519296315,0.655607726314889,TRUE
+"HCC15","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.49619,1.54,0.0781,360,0.309,"CES1, CES2, CDA, UPP1, CYP3A7",1.1073489661227,0.510041520575165,FALSE
+"HCC15","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.4732,-1.48,0.0763,8261,0.985,"LAMC1, COL6A2, ITGA5, HSPG2, COL2A1, ITGA4, TNXB, COL6A3, TNC, COL3A1, CD47, VTN, FN1, COL6A1, COL5A1, SDC2, COL1A1, ITGB3, THBS3, LAMB1, ITGA7, SV2A, COL4A2, SDC1, COL1A2, ITGB8",1.11747546204512,0.00656376950238827,FALSE
+"HCC15","Input","KEGG_ENDOCYTOSIS",0.34167,1.1,0.291,2148,0.497,"DNM3, EGFR, SMURF1, KIT, HSPA1L, EHD4, ARRB1, SMURF2, HSPA2, F2R, RAB11FIP5, ERBB4, DNM1, RAB11A, WWP1, AP2S1, RAB11FIP2, HSPA6, EHD1, AP2A2, ASAP2, EHD2, RAB5C, NEDD4, PLD2, RAB5A, AP2M1, HSPA1A, RAB31, IQSEC2, CLTC, AP2B1, CLTB, IGF1R, ARF6, EEA1, ITCH, PIP5K1A, HRAS, MVB12B, AP2A1, CHMP2A, EHD3, DAB2, RAB5B, SH3GLB2, USP8",0.536107011014093,0.303643611266668,FALSE
+"HCC15","Input","KEGG_ENDOMETRIAL_CANCER",0.23855,0.744,0.781,813,0.822,"EGFR, CDH1, PIK3R3, CTNNB1, AKT1, CTNNA2, CTNNA1",0.1073489661227,0.0851281824599496,FALSE
+"HCC15","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37547,1.18,0.234,1160,0.438,"MAPK13, TJP1, CXCL8, EGFR, TCIRG1, ATP6V0D1, ATP6V0A1, CHUK, MAPK8, ATP6V0A2, JUN",0.630784142589857,0.3585258894959,FALSE
+"HCC15","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.264,-0.82,0.682,7470,0.925,"MAP2K7, PIK3CD, PIK3CB, CDKN1A, CDKN1B, SOS1, NCK2, PAK3, PAK1, GAB1, GSK3B, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, AKT3, PIK3CG, NCK1, CBLB, GRB2, EIF4EBP1",0.166215625343521,0.0338582672609674,FALSE
+"HCC15","Input","KEGG_ETHER_LIPID_METABOLISM",0.56003,1.79,0.031,1505,0.274,"PLPP2, PLPP3, AGPS, LPCAT1, PLD2, PAFAH1B1",1.50863830616573,0.562249437179612,FALSE
+"HCC15","Input","KEGG_FATTY_ACID_METABOLISM",0.49015,1.53,0.0907,1022,0.297,"ALDH2, ECI1, ACSL3, ACADS, ACADSB, ALDH3A2, ALDH7A1, HADHB, ECHS1, EHHADH, ACSL1",1.0423927129399,0.527243550682788,FALSE
+"HCC15","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34917,-1.07,0.338,7470,1,"MAP2K7, MAP2K3, PRKCE, PIK3CD, PIK3CB, PDPK1, SOS1, LCP2, PLCG1, PLCG2, RAF1, BTK, RAC2, PIK3R2, PLA2G12A, PRKCB, AKT3, VAV3, PIK3CG, PRKCD, GRB2, RAC3, INPP5D",0.471083299722345,0,FALSE
+"HCC15","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.30888,-0.943,0.472,8465,0.948,"PLCG1, PLCG2, RAF1, RAC2, GSN, PIK3R2, PRKCB, AKT3, WASF1, VAV3, DOCK2, PIK3CG, PRKCD, PTPRC, FCGR2B, FCGR2C, INPP5D, MARCKSL1, WASF3",0.326058001365912,0.0231916626619338,FALSE
+"HCC15","Input","KEGG_FOCAL_ADHESION",-0.29831,-0.909,0.544,7572,0.956,"CCND1, PIK3CD, COL11A1, ROCK1, PIK3CB, RHOA, PDPK1, THBS1, LAMB2, TLN1, HGF, SOS1, ACTN3, PAK3, PAK1, LAMC1, GSK3B, COL6A2, ITGA5, COL2A1, RAF1, ITGA4, TNXB, CCND2, RAC2, COL6A3, PIK3R2, TNC, PRKCB, COL3A1, MYLK, PDGFRB, AKT3, VTN, FN1, VAV3, PIK3CG, COL6A1, ACTG1, COL5A1, GRB2, COL1A1, RAC3, VEGFA, ITGB3, THBS3, LAMB1, ITGA7, COL4A2, COL1A2, ITGB8",0.26440110030182,0.0195421077238999,FALSE
+"HCC15","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.40989,-1.27,0.184,7440,0.918,"FPGS, DHFR, ALPG, GCH1, ALPI, ALPP",0.735182176990464,0.0371573187987575,FALSE
+"HCC15","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.31955,-0.971,0.415,8060,0.929,"MPI, PFKFB4, ALDOB, HK2, FBP1, FBP2, ALDOC",0.381951903287907,0.0319842860063582,FALSE
+"HCC15","Input","KEGG_GALACTOSE_METABOLISM",0.30693,0.974,0.444,278,0.586,"PFKP, GLA",0.35261702988538,0.232102383981909,FALSE
+"HCC15","Input","KEGG_GAP_JUNCTION",0.30337,0.952,0.479,711,0.603,"TJP1, TUBB2B, ITPR3, EGFR, GNAI1, ADCY9, ADCY5",0.319664486585437,0.219682687859849,FALSE
+"HCC15","Input","KEGG_GLIOMA",-0.41747,-1.3,0.188,7572,1,"CCND1, PIK3CD, PIK3CB, CDKN1A, SOS1, E2F3, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, CDK4, PDGFRB, MDM2, AKT3, PIK3CG, GRB2, RB1, CDKN2A",0.72584215073632,0,FALSE
+"HCC15","Input","KEGG_GLUTATHIONE_METABOLISM",0.4926,1.51,0.0977,505,0.295,"GCLC, GGT1, GSTM4, GSTM3, ODC1, GSTM2, GCLM, GSR, G6PD",1.01010543628123,0.530177984021837,FALSE
+"HCC15","Input","KEGG_GLYCEROLIPID_METABOLISM",0.43127,1.35,0.147,961,0.35,"PLPP2, GLA, ALDH2, AGPAT3, CEL, PLPP3, GPAT3, ALDH3A2, ALDH7A1, DGKE",0.832682665251824,0.455931955649724,FALSE
+"HCC15","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33289,1.04,0.35,1184,0.533,"PLPP2, MBOAT7, AGPAT3, PLPP3, GPAT3, GPD2, PTDSS2, DGKE, LPCAT1, PLD2, GNPAT",0.455931955649724,0.273272790973428,FALSE
+"HCC15","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.54594,1.72,0.0503,1176,0.226,"ALAS1, GLDC, CBS, MAOA, SHMT1, GAMT, PHGDH, SDS",1.29843201494407,0.645891560852599,FALSE
+"HCC15","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.35208,1.12,0.276,1802,0.474,"ALDH3A1, PFKP, ALDH2, ALDH3A2, ALDH3B1, ALDH7A1, DLAT, LDHA, ACSS2, ALDH9A1, PKLR, GALM, ENO3",0.559090917934782,0.324221658325915,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.47352,-1.47,0.101,6273,0.877,"CHPF, CHST14, B3GALT6, CHSY1, UST, CHPF2, B3GAT3, DSE",0.995678626217357,0.0570004066339595,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.31687,0.998,0.423,134,0.566,"GLCE",0.373659632624958,0.247183568811729,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.28245,0.889,0.543,1373,0.662,"ST3GAL1, B4GAT1",0.265200170411153,0.1791420105603,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.37857,1.19,0.211,2467,0.447,"HEXA, GUSB, GALNS, NAGLU, GNS, IDUA, HGSNAT",0.675717544702307,0.349692476868064,FALSE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.55602,1.75,0.0333,871,0.254,"ST3GAL5, HEXA, ST3GAL1",1.47755576649368,0.595166283380062,FALSE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.64249,2.04,0.0126,871,0.17,"GLA, HEXA, ST3GAL1",1.89962945488244,0.769551078621726,TRUE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.36335,1.14,0.248,1373,0.469,"ST3GAL4, B4GAT1",0.605548319173784,0.328827157284917,FALSE
+"HCC15","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.27826,-0.858,0.636,7454,0.92,"GPAA1, PIGN, PIGO, PGAP1, PIGU",0.196542884351586,0.0362121726544447,FALSE
+"HCC15","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.26821,0.846,0.586,1213,0.681,"HYI, CS",0.232102383981909,0.166852888087215,FALSE
+"HCC15","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28335,0.877,0.54,1334,0.669,"MAPK13, ITPR3, EGFR, ADCY9, ADCY5, CACNA1C, MAPK8, JUN, PLD2, MAP2K6, ITPR2, ADCY6",0.267606240177031,0.174573882232177,FALSE
+"HCC15","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.20457,0.644,0.919,2498,0.937,"CSNK1G2, CSNK1G3, SMO, PRKACB, RAB23, CSNK1A1, STK36, BMP4",0.0366844886138887,0.0282604091122217,FALSE
+"HCC15","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.40366,1.25,0.192,684,0.392,"ITGA1, IL1A, KIT, CD14, ITGA6, ITGA3, ITGA2, CD9",0.71669877129645,0.406713932979543,FALSE
+"HCC15","Input","KEGG_HISTIDINE_METABOLISM",0.5574,1.77,0.0397,829,0.253,"ALDH3A1, AMDHD1, ALDH2, MAOA, ALDH3A2, ALDH3B1, ALDH7A1",1.40120949323689,0.596879478824182,FALSE
+"HCC15","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.22548,-0.709,0.853,6332,1,"RAD54L, TOP3B, BRCA2, RAD51, POLD4, RAD51B, XRCC3, SEM1, RAD52, RAD54B",0.069050968832477,0,FALSE
+"HCC15","Input","KEGG_HUNTINGTONS_DISEASE",-0.19488,-0.614,0.955,6353,1,"POLR2D, ATP5PO, CREB5, COX5B, ATP5F1E, GPX1, CASP3, HDAC1, CYCS, ATP5PD, NDUFV2, IFT57, POLR2E, NDUFA7, DLG4, COX7A2L, NDUFAB1, PLCB1, NDUFS6, COX6C, POLR2L, HDAC2, NDUFA6, NDUFS5, HAP1, POLR2C, CREB1, DNAL4, POLR2G, NRF1, TAF4, POLR2J, CREBBP, PPID, UQCRC2, NDUFS4, UQCR10, POLR2I, POLR2K, SP1, POLR2H, PLCB2, GRIN1, UQCRB, UQCRFS1, UQCRQ, POLR2F, DNAH3, REST, EP300",0.0199966284162537,0,FALSE
+"HCC15","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.31101,0.955,0.462,1010,0.605,"ITGA1, ITGB5, ITGB4, DMD, ITGA6, ITGA3, ITGA2, PRKAG1, DES, CACNA1C, LMNA, PRKAA1",0.335358024443874,0.218244625347531,FALSE
+"HCC15","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.33281,-1.06,0.334,7590,0.95,"PIK3CD, PI4KB, PIK3CB, INPP5B, PLCG1, PLCG2, PIP4K2A, IMPA2, PLCB2, INPP4B, PIK3CG, ALDH6A1, PLCZ1",0.476253533188435,0.0222763947111523,FALSE
+"HCC15","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.19482,-0.613,0.948,7590,1,"PIK3CD, PIK3CB, PDPK1, INSR, EIF4E, SOS1, FOXO1, GSK3B, HK2, FBP1, RAF1, PIK3R2, FBP2, AKT3, PIK3CG, CBLB, GRB2, PRKAR2B, INPP5D, EIF4EBP1",0.0231916626619338,0,FALSE
+"HCC15","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.59889,-1.85,0.0318,8608,0.488,"ITGA4, IL6, TNFRSF13C",1.49757288001557,0.311580177997289,FALSE
+"HCC15","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.26103,0.815,0.66,1056,0.729,"IFNGR1, BCL2L1, PIK3R3, LEPR, STAT1, AKT1, IL13RA1, OSMR, IRF9, SPRED1, JAK1",0.180456064458131,0.137272471682025,FALSE
+"HCC15","Input","KEGG_LEISHMANIA_INFECTION",0.33992,1.08,0.317,1160,0.491,"MAPK13, IL1A, IFNGR1, STAT1, PTGS2, JAK1, JUN",0.498940737782249,0.308918507877032,FALSE
+"HCC15","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.30166,0.947,0.47,885,0.604,"MAPK13, CLDN6, OCLN, ACTN4, CD99, PIK3R3, GNAI1, ICAM1, CTNNB1, CTNND1, CLDN1, ROCK2, CTNNA2, CTNNA1, RASSF5",0.327902142064283,0.218963061378868,FALSE
+"HCC15","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.68417,2.21,0.00452,1421,0.105,"ALDH2, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1",2.34486156518862,0.978810700930062,TRUE
+"HCC15","Input","KEGG_LONG_TERM_DEPRESSION",-0.26318,-0.804,0.682,8559,0.941,"RAF1, GNAO1, PLCB2, PLA2G12A, PRKCB, RYR1, PRKG1",0.166215625343521,0.0264103765727431,FALSE
+"HCC15","Input","KEGG_LONG_TERM_POTENTIATION",-0.27297,-0.847,0.603,8559,0.924,"RAF1, PLCB2, PRKCB, GRIN1, CAMK4, EP300",0.219682687859849,0.0343280287798933,FALSE
+"HCC15","Input","KEGG_LYSINE_DEGRADATION",-0.29447,-0.924,0.517,7341,0.971,"KMT5B, SETD7, AASS, ALDH1B1, NSD1, DOT1L, NSD3, PLOD3, GCDH, SETD2, SETDB2, PLOD1, PLOD2, SETMAR, NSD2",0.286509456906058,0.0127807700919951,FALSE
+"HCC15","Input","KEGG_LYSOSOME",0.42822,1.33,0.146,1901,0.357,"AGA, SLC11A2, TCIRG1, CTSV, GLA, CLN3, FUCA1, AP1S3, SLC17A5, SORT1, LIPA, ATP6V0D1, LAPTM4A, CTSL, LGMN, CTSZ, HEXA, ATP6V0A1, AP1S2, GUSB, GALNS, CD63, ATP6V0A2, PPT2, CTSF, AP1M1, CLTC, CLTB, NAGLU, IGF2R, AP4M1, NAGPA, NPC2, ABCA2, AP1G1, AP4E1, GNS, MANBA, ACP2, ATP6AP1",0.835647144215563,0.447331783887807,FALSE
+"HCC15","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.24266,0.767,0.784,1309,0.791,"MAPK13, IL1A, TGFBR2, EGFR, FLNB, HSPA1L, CD14, RELB, ARRB1, HSPA2, MOS, RRAS2, NFKB2, RPS6KA5, AKT1, DDIT3, CACNA1C, PPP5C, HSPA6, RRAS, CDC25B, RASGRP2, CHUK, MAPK8, JUN, GNG12, MAP2K6, FLNC, HSPA1A",0.105683937315562,0.101823516502323,FALSE
+"HCC15","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.64114,2.01,0.0134,1549,0.171,"PDX1, PKLR",1.87289520163519,0.767003889607846,TRUE
+"HCC15","Input","KEGG_MELANOGENESIS",-0.28721,-0.893,0.574,8294,0.971,"GSK3B, KITLG, TCF7L1, RAF1, GNAO1, PLCB2, PRKCB, WNT10A, WNT5A, MITF, EP300",0.241088107602027,0.0127807700919951,FALSE
+"HCC15","Input","KEGG_MELANOMA",-0.45576,-1.42,0.0986,7572,0.911,"CCND1, PIK3CD, PIK3CB, CDKN1A, FGFR1, HGF, E2F3, RAF1, PIK3R2, CDK4, PDGFRB, MDM2, AKT3, FGF13, FGF2, PIK3CG, MITF, FGF1, RB1, CDKN2A",1.00612308505879,0.0404816230270017,FALSE
+"HCC15","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.66437,2.14,0.00823,781,0.129,"ALDH3A1, CYP2S1, AKR1C3, GSTM4, EPHX1, GSTM3, GSTM2, CYP3A7, AKR1C1, ALDH3B1",2.08460016478773,0.889410289700751,TRUE
+"HCC15","Input","KEGG_MISMATCH_REPAIR",0.48924,1.53,0.0843,2364,0.297,"MSH6, MSH2, POLD1, PMS2, LIG1, MLH1, RFC1, MSH3, POLD3",1.07417242537526,0.527243550682788,FALSE
+"HCC15","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.27939,-0.88,0.552,7525,0.931,"CAB39L, PIK3CD, PIK3CB, PDPK1, EIF4E, PIK3R2, AKT3, PIK3CG, VEGFA, EIF4EBP1",0.258060922270801,0.0310503190186574,FALSE
+"HCC15","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.27514,0.859,0.604,710,0.693,"IFNGR1, SYK, ICAM2, TNFRSF10A, ULBP3, PIK3R3, MICB, ICAM1, RAET1L, ULBP2",0.218963061378868,0.159266765388193,FALSE
+"HCC15","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34275,1.08,0.337,1517,0.491,"LEPR, F2R, P2RX4, HCRTR1, NR3C1, TACR1",0.472370099128661,0.308918507877032,FALSE
+"HCC15","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.19855,-0.61,0.955,7383,1,"YWHAB, MAP2K7, NFKB1, MAP3K5, PIK3CD, PIK3CB, RHOA, PDPK1, FOXO3, SOS1, GAB1, GSK3B, PLCG1, PLCG2, RAF1, PIK3R2, AKT3, MAGED1, PIK3CG, PRKCD, GRB2, CAMK4, ARHGDIB",0.0199966284162537,0,FALSE
+"HCC15","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.52387,1.64,0.0528,1098,0.248,"NNMT, QPRT, NAMPT, NT5E, NNT, NT5C2",1.27736607746619,0.605548319173784,FALSE
+"HCC15","Input","KEGG_NITROGEN_METABOLISM",-0.39534,-1.25,0.193,9360,0.793,"GLUL, CA8, CA2",0.714442690992226,0.100726812682396,FALSE
+"HCC15","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.33409,1.03,0.387,1220,0.541,"MAPK13, IL18, CXCL8, CCL13, CHUK, MAPK8, BIRC2, PYCARD, CASP5",0.412289034981089,0.266802734893431,FALSE
+"HCC15","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.57268,1.78,0.026,1970,0.262,"RAD50, PRKDC, NHEJ1, XRCC6, XRCC5, MRE11",1.58502665202918,0.581698708680255,FALSE
+"HCC15","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.44561,-1.38,0.132,7572,0.93,"CCND1, PIK3CD, PIK3CB, PDPK1, FOXO3, SOS1, E2F3, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, CDK4, AKT3, PIK3CG, GRB2, STK4, RB1, FHIT, CDKN2A",0.87942606879415,0.0315170514460649,FALSE
+"HCC15","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.39566,-1.25,0.176,6513,0.793,"HDAC1, MAML1, NUMBL, CIR1, NCSTN, RBPJ, HDAC2, SNW1, DVL3, CTBP1, NCOR2, JAG1, CREBBP, NOTCH3, DTX3, EP300",0.75448733218585,0.100726812682396,FALSE
+"HCC15","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.46661,1.49,0.0956,2100,0.295,"CUL4B, DDB2, ERCC8, GTF2H3, ERCC2, GTF2H4, ERCC3, POLD1, GTF2H2, CDK7, LIG1, CCNH, DDB1, GTF2H1, RFC1, POLE4, ERCC4",1.0195421077239,0.530177984021837,FALSE
+"HCC15","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.18783,-0.584,0.961,6759,1,"STT3B, B4GALT3, ALG11, FUT8, DPM3, ALG10, ALG10B, DAD1, MGAT3, MAN1A2, MAN1A1, ST6GAL1",0.0172766123314547,0,FALSE
+"HCC15","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.35419,-1.09,0.308,8784,0.993,"PRKG1, PDE1C",0.511449283499556,0.00305075150461883,FALSE
+"HCC15","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.26886,0.847,0.666,2649,0.692,"SHMT1, MTHFS, AMT, MTFMT, ATIC, GART",0.176525770829699,0.159893905543242,FALSE
+"HCC15","Input","KEGG_OOCYTE_MEIOSIS",0.26817,0.846,0.614,2127,0.681,"ITPR3, MOS, ADCY9, ADCY5, AR, CCNB1, ITPR2, ADCY6, PPP2R5D, CDC27, IGF1R, YWHAZ, CDC23, ANAPC7, PRKACB, ANAPC4, CDC16, PPP3CC, ITPR1, ANAPC2, ESPL1",0.211831628858832,0.166852888087215,FALSE
+"HCC15","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.56931,1.83,0.0156,743,0.284,"AGA, FUCA2, FUCA1, MAN2B2, HEXA",1.80687540164554,0.546681659952962,FALSE
+"HCC15","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.1544,-0.487,0.998,6739,0.996,"ATP5PD, NDUFV2, ATP6V1D, ATP5MG, NDUFA7, COX7A2L, NDUFAB1, NDUFS6, COX6C, NDUFA6, COX11, NDUFS5, ATP6V1F, PPA2, ATP5ME, UQCRC2, NDUFS4, UQCR10, COX17, ATP6V1G1, ATP6V1E1, UQCRB, UQCRFS1, UQCRQ",0.000869458712628891,0.00174066157630127,FALSE
+"HCC15","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.45865,1.46,0.0916,1429,0.292,"ST3GAL1, GALNT5, C1GALT1, GALNT13, GALNT15, GALNT7, B3GNT6, C1GALT1C1",1.03810452633215,0.534617148551582,FALSE
+"HCC15","Input","KEGG_P53_SIGNALING_PATHWAY",-0.24114,-0.744,0.737,6416,0.992,"TNFRSF10B, TP53I3, CASP3, CYCS, CHEK1, GTSE1, COP1, PPM1D, SERPINE1, CD82, CCND1, CDKN1A, THBS1, RCHY1, CHEK2, CCND2, CDK4, MDM2, IGFBP3, CDKN2A",0.132532512140949,0.00348832784582135,FALSE
+"HCC15","Input","KEGG_PANCREATIC_CANCER",-0.28514,-0.881,0.603,8553,0.952,"ARHGEF6, RAF1, RAC2, PIK3R2, CDK4, AKT3, SMAD4, PIK3CG, RAC3, VEGFA, RB1, CDKN2A",0.219682687859849,0.0213630516155257,FALSE
+"HCC15","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.54978,1.74,0.0265,1555,0.221,"BCAT1, BCAT2, PPCS, COASY",1.57675412606319,0.655607726314889,TRUE
+"HCC15","Input","KEGG_PARKINSONS_DISEASE",-0.16333,-0.517,0.994,8189,1,"PPID, UQCRC2, NDUFS4, UQCR10, UBE2L3, UBE2G1, UQCRB, UQCRFS1, UQCRQ, SNCA",0.00261361560268669,0,FALSE
+"HCC15","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.34997,1.12,0.267,729,0.474,"TUBB2B, OCLN, CDH1, CD14, CTNNB1, ARPC1A, CLDN1, ROCK2",0.573488738635425,0.324221658325915,FALSE
+"HCC15","Input","KEGG_PATHWAYS_IN_CANCER",-0.27189,-0.841,0.628,7526,0.918,"NFKB1, BCR, DVL3, CCND1, PIK3CD, PIK3CB, CDKN1A, RHOA, CTBP1, FGFR1, LAMB2, CDKN1B, BIRC5, HGF, SOS1, ARNT, CREBBP, MECOM, FOXO1, PIAS1, RUNX1, CKS1B, LAMC1, GSK3B, E2F3, KITLG, TCF7L1, PLCG1, PLCG2, PIAS4, RAF1, RAC2, PIK3R2, PRKCB, RUNX1T1, CDK4, PDGFRB, MDM2, PIAS2, CEBPA, IL6, AKT3, SKP2, WNT10A, SMAD4, WNT5A, FN1, PAX8, FGF13, FGF2, PIK3CG, MMP2, CBLB, GRB2, RAC3, VEGFA, MAX, STK4, LAMB1, SPI1, COL4A2, MITF, FGF1, RB1, EP300, CDKN2A",0.202040356262804,0.0371573187987575,FALSE
+"HCC15","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.42385,1.37,0.112,973,0.344,"UGDH, GUSB",0.950781977329818,0.46344155742847,FALSE
+"HCC15","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.31498,1,0.391,505,0.57,"PFKP, TALDO1, RBKS, G6PD",0.407823242604133,0.244125144327509,FALSE
+"HCC15","Input","KEGG_PEROXISOME",0.53609,1.66,0.058,2653,0.253,"SLC27A2, ABCD1, PECR, DECR2, ACSL3, PEX16, AMACR, NUDT19, PEX3, CROT, MPV17, EHHADH, ACSL1, PXMP4, AGPS, PEX1, GNPAT, PEX6, FAR1, PEX10, PRDX1, SCP2, GSTK1, PEX11B, SLC25A17, ECI2, PEX13, ACOX1, DHRS4, ACSL6, ABCD3, PHYH, CAT, CRAT",1.23657200643706,0.596879478824182,FALSE
+"HCC15","Input","KEGG_PHENYLALANINE_METABOLISM",0.55262,1.74,0.0334,1123,0.221,"ALDH3A1, MAOA, ALDH3B1, GOT1",1.47625353318844,0.655607726314889,TRUE
+"HCC15","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.28458,-0.887,0.573,7590,0.961,"PIK3CD, PI4KB, PIK3CB, DGKD, INPP5B, CDS1, PLCG1, DGKH, PLCG2, PIP4K2A, PIK3R2, IMPA2, PLCB2, PRKCB, INPP4B, PIK3CG, PLCZ1, INPP5D",0.24184537803261,0.0172766123314547,FALSE
+"HCC15","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.45006,1.43,0.107,2433,0.297,"BLVRB, BLVRA, ALAS1, HMOX2, GUSB, HMBS, COX15, PPOX, EARS2, FECH, FTH1",0.97061622231479,0.527243550682788,FALSE
+"HCC15","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.30026,-0.919,0.518,8886,0.957,"SCD, APOC3, ACSL4, LPL, FADS2, PLTP, SCD5",0.285670240254767,0.0190880622231565,FALSE
+"HCC15","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.60596,-1.88,0.0226,8612,0.651,"BTK, RFX5, CD79A, RFXANK, PTPRC, RFXAP, TNFRSF13C",1.6458915608526,0.186419011431808,FALSE
+"HCC15","Input","KEGG_PRION_DISEASES",0.28477,0.919,0.506,561,0.623,"IL1A, C9",0.295849483160201,0.20551195334083,FALSE
+"HCC15","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.37195,1.18,0.23,2398,0.438,"MAPK13, FZR1, PIK3R3, MOS, GNAI1, ADCY9, AKT1, ADCY5, CDC25B, MAPK8, CCNB1, ADCY6, CDC27, IGF1R, CDC23, ANAPC7, PRKACB, ANAPC4, CDC16, GNAI3, MAPK9, ANAPC2, AKT2, MAPK10, PKMYT1, HSP90AB1",0.638272163982407,0.3585258894959,FALSE
+"HCC15","Input","KEGG_PROPANOATE_METABOLISM",0.41893,1.29,0.157,1421,0.367,"ALDH2, MCEE, ACACA, ALDH3A2, ACACB, ALDH7A1, ECHS1, EHHADH, LDHA, ACSS2, ALDH9A1",0.804100347590766,0.435333935747911,FALSE
+"HCC15","Input","KEGG_PROSTATE_CANCER",-0.37041,-1.17,0.242,7418,0.855,"HSP90B1, NFKB1, CCND1, PIK3CD, CREB1, PIK3CB, CDKN1A, PDPK1, FGFR1, CDKN1B, SOS1, CREBBP, FOXO1, GSK3B, E2F3, TCF7L1, RAF1, PIK3R2, PDGFRB, MDM2, AKT3, PIK3CG, GRB2, RB1, EP300",0.616184634019569,0.0680338852718274,FALSE
+"HCC15","Input","KEGG_PROTEASOME",0.30995,0.975,0.44,3713,0.592,"PSMB8, PSME2, PSME1, PSMD1, PSMD3, PSMD12, PSMD11, PSME4, PSMB2, PSMD6, PSMA6, PSMB1, PSMB5, PSMB4, PSMA4, PSMD13, PSMC3, PSMA2, PSMC5, PSMC4, PSMD2, PSMA7, PSMA3, PSMC2, PSMA5",0.356547323513813,0.22767829327708,FALSE
+"HCC15","Input","KEGG_PROTEIN_EXPORT",0.2489,0.803,0.736,2587,0.744,"SEC63, SEC11A, SRPRA, SPCS2, SRP68, SRP14, SRP72, SRP54",0.133122185662501,0.128427064454121,FALSE
+"HCC15","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.40714,-1.26,0.16,8380,0.879,"ATP1B3, SLC4A4, SLC38A3, CA2",0.795880017344075,0.0560111249262281,FALSE
+"HCC15","Input","KEGG_PURINE_METABOLISM",-0.17481,-0.552,0.974,6682,1,"AMPD2, APRT, PAICS, NPR2, POLD4, POLR2E, NT5C, NUDT9, PNP, POLR2L, GMPS, ITPA, NUDT2, PRPS2, PDE3B, POLR2C, PDE5A, IMPDH1, PRUNE1, POLR2G, ENTPD6, POLR2J, CANT1, NT5C3A, POLR2I, POLR2K, DCK, POLR2H, POLR3G, PDE1C, IMPDH2, POLR2F, FHIT, PDE2A",0.0114410431213845,0,FALSE
+"HCC15","Input","KEGG_PYRIMIDINE_METABOLISM",-0.19577,-0.605,0.954,6792,1,"POLD4, POLR2E, NT5C, PNP, POLR2L, UCKL1, ITPA, NUDT2, POLR2C, POLR2G, UPRT, ENTPD6, POLR2J, CANT1, NT5C3A, POLR2I, TYMS, POLR2K, DCK, POLR2H, UCK2, POLR3G, POLR2F, TXNRD2",0.0204516252959049,0,FALSE
+"HCC15","Input","KEGG_PYRUVATE_METABOLISM",0.53627,1.7,0.0485,1549,0.231,"ME1, ME3, GLO1, ALDH2, PC, ACACA, ALDH3A2, ACACB, ALDH7A1, DLAT, LDHA, ACSS2, ALDH9A1, PKLR",1.31425826139774,0.636388020107856,TRUE
+"HCC15","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.24873,0.77,0.754,612,0.794,"ITGA1, IQGAP2, EGFR, ITGB5, CFL2, ACTN4, ITGB4, CD14, ITGA6, PIK3R3, ITGA3, IQGAP1, ITGA2, RDX, F2R, MOS, RRAS2, ARPC1A, GNA13",0.122628654130226,0.100179497572904,FALSE
+"HCC15","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.18543,-0.572,0.979,6494,1,"PIK3C3, PIK3R4, GABARAPL2, ATG4B, ATG3",0.00921730819686218,0,FALSE
+"HCC15","Input","KEGG_RENAL_CELL_CARCINOMA",-0.28262,-0.87,0.575,7590,0.934,"PIK3CD, PIK3CB, HGF, SOS1, ARNT, CREBBP, PAK3, PAK1, GAB1, RAF1, PIK3R2, AKT3, PIK3CG, GRB2, VEGFA, EP300",0.24033215531037,0.0296531237699066,FALSE
+"HCC15","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.66735,-2.04,0.00188,7871,0.638,"CTSG, ACE, MME, ANPEP, CPA3, CTSA",2.72584215073632,0.195179321278838,FALSE
+"HCC15","Input","KEGG_RETINOL_METABOLISM",0.4217,1.33,0.136,715,0.357,"CYP3A7, RETSAT, ALDH1A1",0.866461091629782,0.447331783887807,FALSE
+"HCC15","Input","KEGG_RIBOFLAVIN_METABOLISM",0.41018,1.28,0.186,2858,0.371,"RFK, ACP2, FLAD1, MTMR2",0.730487055782084,0.430626090384954,FALSE
+"HCC15","Input","KEGG_RIBOSOME",0.513,1.61,0.0567,2751,0.264,"RPL26L1, RPL37, RPL19, RPS4Y1, RPL34, RPS6, RPL15, RPL36A, RPL36AL, RPL26, RPS13, RPL37A, RPS11, RPL24, RSL24D1, RPL27A, RPS18, RPL7, RPL35, RPL36, RPS24, RPL13A, RPS7, RPS16, RPS26, RPL6, RPL18A, RPL27, RPL18, RPS8, FAU, RPL3, RPS3A, RPL21, RPS2, RPL32, RPL9, RPL8, RPL10A, RPL28, RPS10, RPS3, RPL35A, RPS9, RPS15A, RPS23, RPL29, RPL5, RPL4, RPS20, RPL14, RPS4X, RPL38, RPL31, RPL23A, RPL7A",1.24641694110709,0.578396073130169,FALSE
+"HCC15","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.44128,1.41,0.109,3008,0.309,"MAPK13, IFIH1, ISG15, CXCL8, DDX58, NLRX1, CHUK, MAPK8, CYLD, MAPK9, NFKBIB, RIPK1, MAPK10, ATG5, CASP8, TANK, TRAF2, PIN1, IRF3, RELA, TRADD, CXCL10, CASP10, TKFC, DDX3X",0.962573502059376,0.510041520575165,FALSE
+"HCC15","Input","KEGG_RNA_DEGRADATION",-0.18615,-0.583,0.97,5585,1,"CNOT8, EXOSC4, CNOT9, EXOSC6, LSM3, PAPOLG, CNOT6, CNOT2, XRN1, EDC3, CNOT3, ZCCHC7, LSM7, CNOT4, LSM8, MPHOSPH6, LSM2, LSM4, DCP1A, LSM6, DCP1B, LSM1, C1D, LSM5",0.0132282657337552,0,FALSE
+"HCC15","Input","KEGG_RNA_POLYMERASE",-0.49911,-1.56,0.062,5378,0.906,"POLR1B, POLR2B, POLR3K, POLR3D, POLR3F, POLR1C, POLR1D, POLR2D, POLR3H, POLR2E, POLR2L, POLR2C, POLR2G, POLR2J, POLR2I, POLR2K, POLR2H, POLR3G, POLR2F",1.20760831050175,0.0428718023231869,FALSE
+"HCC15","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.46946,1.45,0.0982,587,0.286,"GGT1, PAPSS2, MAT1A, CBS",1.00788851221305,0.543633966870957,FALSE
+"HCC15","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.31449,-0.982,0.431,7083,0.961,"LAMA1, LAMA5, LAMA3, LAMA4, TRAF4, NFKB1, CCND1, PIK3CD, PIK3CB, LAMB2, CDKN1B, PIAS1, CKS1B, LAMC1, E2F3, PIAS4, PIK3R2, CDK4, PIAS2, AKT3, SKP2, FN1, PIK3CG, MAX, LAMB1, COL4A2, RB1, FHIT",0.365522729839268,0.0172766123314547,FALSE
+"HCC15","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.52043,1.64,0.0399,1679,0.248,"STX3, VAMP7, VAMP8, STX5, VTI1A, VAMP2, STX12, VAMP3, STX4, STX7, BET1, YKT6, SNAP23, GOSR1",1.39902710431325,0.605548319173784,TRUE
+"HCC15","Input","KEGG_SPHINGOLIPID_METABOLISM",0.47522,1.48,0.083,482,0.297,"PLPP2, UGCG, GLA, SGPL1, PLPP3",1.08092190762393,0.527243550682788,FALSE
+"HCC15","Input","KEGG_SPLICEOSOME",-0.24176,-0.744,0.763,5674,0.992,"SRSF4, MAGOHB, SRSF9, DDX5, ALYREF, DHX8, THOC3, NCBP2, SF3B4, SNRNP40, HNRNPM, SF3A1, LSM3, PPIH, PPIE, HNRNPA1, SLU7, SF3B5, SNU13, SRSF2, PCBP1, U2SURP, HNRNPA3, PRPF4, TXNL4A, SRSF10, SF3B6, SRSF5, LSM7, HNRNPC, SNRPC, SRSF3, CCDC12, SF3A2, SMNDC1, SNW1, RBM8A, LSM8, SNRPA1, SART1, LSM2, SRSF1, LSM4, PRPF18, LSM6, RBM17, SF3B2, SNRPB, ZMAT2, SNRPG, CWC15, PHF5A, ISY1, PRPF40B, SYF2, LSM5",0.11747546204512,0.00348832784582135,FALSE
+"HCC15","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.41088,1.29,0.168,973,0.367,"PGM2L1, UGDH, GUSB",0.774690718274137,0.435333935747911,FALSE
+"HCC15","Input","KEGG_STEROID_BIOSYNTHESIS",-0.41751,-1.28,0.174,8601,0.964,"SQLE, MSMO1, FDFT1, CYP51A1",0.7594507517174,0.0159229660971692,FALSE
+"HCC15","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.50366,1.59,0.0607,560,0.271,"AKR1C3, CYP21A2, CYP3A7, AKR1C1",1.21681130892474,0.567030709125594,FALSE
+"HCC15","Input","KEGG_SULFUR_METABOLISM",0.87387,2.75,0,234,0.004,"SULT1A3, PAPSS2, SULT1A1",Inf,2.39794000867204,TRUE
+"HCC15","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.30277,-0.967,0.458,7662,0.911,"C3, CTSG, SNRPB, ACTN3, ELANE, C4A, FCGR2B, FCGR2C",0.339134521996131,0.0404816230270017,FALSE
+"HCC15","Input","KEGG_TASTE_TRANSDUCTION",0.45887,1.47,0.0809,1816,0.298,"ITPR3, ADCY6, PRKACB, KCNB1",1.09205147838773,0.525783735923745,FALSE
+"HCC15","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.24242,-0.744,0.787,7277,0.992,"HMGCR, PMVK, HMGCS1",0.104025267640935,0.00348832784582135,FALSE
+"HCC15","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.33064,-1.01,0.424,8504,0.947,"E2F4, SP1, AMH, SMAD4, ID3, E2F5, TFDP1, LTBP1, THBS3, DCN, EP300",0.372634143407267,0.0236500209967266,FALSE
+"HCC15","Input","KEGG_THYROID_CANCER",0.21511,0.668,0.888,567,0.918,"CDH1, CTNNB1",0.051587034221399,0.0371573187987575,FALSE
+"HCC15","Input","KEGG_TIGHT_JUNCTION",0.30445,0.966,0.463,888,0.593,"CLDN6, TJP1, OCLN, ACTN4, TJP2, EPB41L3, GNAI1, RRAS2, CTNNB1, SPTAN1, AKT1, CLDN1, CTNNA2, CTNNA1, LLGL2, RRAS",0.334419008982047,0.226945306635737,FALSE
+"HCC15","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31747,0.995,0.413,1198,0.564,"MAPK13, CXCL8, CD40, CD14, PIK3R3, STAT1, AKT1, CHUK, MAPK8, JUN, MAP2K6",0.384049948343599,0.248720896016658,FALSE
+"HCC15","Input","KEGG_TRYPTOPHAN_METABOLISM",0.59759,1.89,0.0216,1016,0.253,"KYNU, ALDH2, MAOA, OGDH, ALDH3A2, ALDH7A1, ECHS1, OGDHL, EHHADH",1.66554624884907,0.596879478824182,FALSE
+"HCC15","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.2252,0.696,0.838,1012,0.888,"PIK3R3, IRS1, CACNA1C, PDX1, MAPK8",0.0767559813697235,0.051587034221399,FALSE
+"HCC15","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.56543,-1.75,0.0301,9482,0.555,"CPE, ICA1",1.52143350440616,0.255707016877324,FALSE
+"HCC15","Input","KEGG_TYROSINE_METABOLISM",0.42033,1.32,0.155,1123,0.36,"ALDH3A1, FAH, MAOA, ALDH3B1, GOT1",0.809668301829709,0.443697499232713,FALSE
+"HCC15","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31141,-0.979,0.441,7470,0.938,"MAP2K7, NFKB1, PIK3CD, PIK3CB, RHOA, PDPK1, NFATC4, SOS1, NCK2, LCP2, PAK3, PRKCQ, PAK1, NFATC1, GSK3B, PLCG1, RAF1, PIK3R2, CDK4, AKT3, VAV3, NFATC2, PIK3CG, GRAP2, NCK1, CBLB, GRB2, PTPRC",0.355561410532161,0.0277971616209356,FALSE
+"HCC15","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.1932,0.609,0.943,2072,0.96,"MID1, SMURF1, FZR1, PML, CUL4B, SMURF2, DDB2, ERCC8, WWP2, WWP1, BIRC2, NEDD4, CDC27, UBE4A, UBE2H, STUB1, CDC23, ITCH, ANAPC7, ANAPC4, CDC16, SAE1, DDB1, CUL5, ANAPC2, HUWE1, UBE3B",0.0254883072626717,0.0177287669604316,FALSE
+"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.74502,2.34,0.0022,518,0.113,"BCAT1, BCAT2, IARS2",2.65757731917779,0.94692155651658,TRUE
+"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37736,1.15,0.245,1150,0.463,"ALDH2, BCAT1, BCAT2, ACADS, MCEE, ACADSB, ALDH3A2, ALDH7A1, HADHB, ECHS1, EHHADH, AUH",0.610833915635468,0.334419008982047,FALSE
+"HCC15","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.29982,0.916,0.531,1432,0.621,"KCNMA1, ITPR3, ADCY9, GNA13, ADCY5, ROCK2, CACNA1C, ARHGEF11, CALD1, NPR1, ITPR2, ADCY6, ARHGEF1, MYH11",0.274905478918531,0.20690839982342,FALSE
+"HCC15","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.35858,1.13,0.288,2349,0.475,"ADCY9, DYNC1LI2, RAB11A, VAMP2, DYNC1H1, RAB5C, STX4, RAB5A, ADCY6, PRKACB, DYNLL2, RAB5B, DCTN1, NSF, DYNC1I1",0.540607512240769,0.323306390375133,FALSE
+"HCC15","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32366,-1,0.429,7590,0.943,"PIK3CD, PIK3CB, SH2D2A, NFATC4, NFATC1, PLCG1, PLCG2, RAF1, RAC2, PIK3R2, PLA2G12A, PRKCB, HSPB1, AKT3, NFATC2, PIK3CG, RAC3, VEGFA",0.367542707815276,0.0254883072626717,FALSE
+"HCC15","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.43625,1.35,0.135,1019,0.35,"TJP1, TCIRG1, TJP2, ERO1A, SLC12A2, ATP6V0D1, ADCY9, ATP6V0A1, KDELR3, ATP6V0A2",0.869666231504994,0.455931955649724,FALSE
+"HCC15","Input","KEGG_VIRAL_MYOCARDITIS",0.27096,0.854,0.63,519,0.694,"CD40, DMD, CXADR, ICAM1",0.200659450546418,0.158640529545145,FALSE
+"HCC15","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24023,-0.725,0.796,7533,1,"DVL3, CCND1, SFRP1, ROCK1, RHOA, CTBP1, PPP2R5E, NFATC4, LRP6, CREBBP, SENP2, NFATC1, GSK3B, TCF7L1, CCND2, RAC2, LRP5, PLCB2, PRKCB, WNT10A, SMAD4, WNT5A, CHD8, NFATC2, RAC3, VANGL2, TBL1XR1, EP300",0.0990869322623309,0,FALSE
+"HCC44","Input","KEGG_ABC_TRANSPORTERS",0.27486,0.867,0.593,1943,0.78,"ABCC3, TAP2, ABCG1, ABCA1, ABCD4, ABCG2, ABCC4, ABCA3, TAP1",0.226945306635737,0.10790539730952,FALSE
+"HCC44","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.36325,-1.04,0.348,7099,0.6,"PIK3CA, RAF1, AKT2, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, BAD, SOS1, PIK3CD, EIF4EBP1, KIT, LEF1",0.458420756053419,0.221848749616356,FALSE
+"HCC44","Input","KEGG_ADHERENS_JUNCTION",-0.36307,-1.06,0.364,7376,0.64,"MAPK1, SSX2IP, TCF7L2, TCF7L1, MAPK3, ERBB2, CDH1, PTPN6, CTNNA2, CTNNA1, CTNND1, SRC, CTNNB1, WASF3, FARP2, RAC3, NECTIN4, FGFR1, PTPRF, NECTIN1, LEF1",0.438898616350944,0.193820026016113,FALSE
+"HCC44","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.36766,-1.07,0.352,7212,0.658,"PRKCQ, AKT2, CAMKK2, RXRA, PRKAA1, NFKBIE, PRKAG1, RXRG, CD36, ADIPOR1, ACSL1, ACSL6",0.453457336521869,0.181774106386044,FALSE
+"HCC44","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.59494,-1.73,0.0222,8712,0.434,"GLUL, ABAT, ALDH5A1, GLUD2",1.65364702554936,0.362510270487489,FALSE
+"HCC44","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.34789,-1.03,0.392,6325,0.598,"ATP1B1, PIK3R1, PIK3R2, IRS1, ATP1A4, INSR, ATP1A1, ATP1A3, PIK3CA, MAPK1, MAPK3, PDPK1, SCNN1A, PIK3CD, HSD11B2",0.406713932979543,0.223298816011589,FALSE
+"HCC44","Input","KEGG_ALZHEIMERS_DISEASE",-0.3673,-1.09,0.33,7130,0.645,"GNAQ, FAS, PPP3CC, COX5A, ATP5PF, PLCB3, CASP9, MAPK1, MAPK3, CDK5, APP, CASP8, MME, NCSTN, GRIN1, FADD, APH1A, CAPN1, BAD, ATP2A3, APOE, GSK3B, MAPT, CALM2, LPL, NDUFA4, CALML3, PPP3R1, PLCB4, APBB1, SNCA, BACE1",0.481486060122112,0.190440285364732,FALSE
+"HCC44","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.27894,0.866,0.582,2386,0.768,"RARS2, WARS2, FARS2, MARS2, MTFMT, LARS2",0.235077015350112,0.114638779968488,FALSE
+"HCC44","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.28436,0.893,0.57,2234,0.782,"GFPT2, GNPNAT1, GCK, GALE, UGDH, UXS1, PGM3, GMDS, HEXA, NANS",0.244125144327509,0.106793246940152,FALSE
+"HCC44","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.26042,0.803,0.712,272,0.816,"PRPH, PRPH2, NEFH, NEFM",0.147520006363144,0.0883098412461389,FALSE
+"HCC44","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.5863,1.8,0.0288,1943,0.562,"CD74, CTSS, RFXAP, TAPBP, B2M, RFX5, IFI30, CTSB, TAP2, PSME1, PSME2, PSME3, LGMN, HSPA5, CALR, TAP1",1.54060751224077,0.250263684430939,FALSE
+"HCC44","Input","KEGG_APOPTOSIS",-0.21172,-0.609,0.956,7099,0.982,"PIK3CA, IL1RAP, FAS, PPP3CC, AKT2, CASP9, CASP8, ENDOD1, FADD, CASP6, CAPN1, PRKAR2B, BAD, PIK3CD, BCL2, PPP3R1, TP53",0.0195421077238999,0.00788851221305034,FALSE
+"HCC44","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.63466,1.96,0.0102,99,0.567,"PTGES, PTGS2, PLA2G4A, GGT1",1.99139982823808,0.246416941107093,FALSE
+"HCC44","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.3632,-1.05,0.342,8510,0.635,"GATM, GLUL, CKMT1A, GLUD2",0.465973893943865,0.197226274708024,FALSE
+"HCC44","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.46641,-1.38,0.107,8197,0.566,"CTNNA2, CTNNA1, DAG1, SGCB, ITGB6, CTNNB1, PKP2, ITGA6, ITGA11, SGCG, DSC2, CACNA2D1, ITGA4, LEF1, CDH2, ITGB8",0.97061622231479,0.247183568811729,FALSE
+"HCC44","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56049,1.76,0.0232,2844,0.44,"ALDH2, ALDH1B1, UGDH, ALDH3A2, ALDH7A1",1.6345120151091,0.356547323513813,FALSE
+"HCC44","Input","KEGG_AXON_GUIDANCE",-0.44133,-1.3,0.156,7185,0.58,"EPHA5, LIMK2, PPP3CC, EFNA5, EPHB1, PAK4, SEMA4C, DPYSL2, MAPK1, NTN4, ARHGEF12, MAPK3, CDK5, L1CAM, EPHA1, DPYSL5, EPHA7, EPHB4, EFNB1, EFNA1, SEMA3C, PLXNA3, PLXNA2, ROBO1, NCK2, PAK5, PAK6, GSK3B, RAC3, EPHB3, PLXNB3, PPP3R1, SEMA4D, EPHA4, EPHA3, SEMA6D, SEMA5A",0.806875401645538,0.236572006437063,FALSE
+"HCC44","Input","KEGG_BASAL_CELL_CARCINOMA",-0.46082,-1.35,0.127,6849,0.6,"APC, WNT5A, FZD1, SUFU, WNT11, TCF7L2, TCF7L1, FZD6, CTNNB1, GSK3B, TP53, LEF1",0.896196279044043,0.221848749616356,FALSE
+"HCC44","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.60458,1.85,0.0265,2061,0.603,"TAF12, GTF2F1, GTF2F2, GTF2E2, GTF2H2, TAF11, GTF2A2, GTF2E1, TBP, GTF2H1, GTF2H3, TAF9, TAF10, GTF2H4, GTF2B",1.57675412606319,0.219682687859849,FALSE
+"HCC44","Input","KEGG_BASE_EXCISION_REPAIR",0.16293,0.495,0.995,1419,0.995,"PARP2, HMGB1, MBD4, NTHL1",0.00217691925427455,0.00217691925427455,FALSE
+"HCC44","Input","KEGG_BETA_ALANINE_METABOLISM",0.23723,0.725,0.805,1312,0.882,"ALDH2, EHHADH, MLYCD, ALDH1B1",0.0942041196321315,0.0545314148681803,FALSE
+"HCC44","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.31543,0.974,0.451,1391,0.699,"ELOVL5, ACOT2, ACOT1, HACD2, YOD1, ACOT7",0.345823458122039,0.155522824254319,FALSE
+"HCC44","Input","KEGG_BLADDER_CANCER",0.3647,1.16,0.243,170,0.599,"MYC, MMP1, CDKN2A, VEGFA",0.614393726401688,0.222573177610689,FALSE
+"HCC44","Input","KEGG_BUTANOATE_METABOLISM",-0.36396,-1.05,0.36,8659,0.635,"ACADS, ABAT, ALDH5A1, HMGCS1",0.443697499232713,0.197226274708024,FALSE
+"HCC44","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.38816,-1.12,0.303,7081,0.689,"NFATC2, PIK3CA, RAF1, PPP3CC, AKT2, MAPK1, VAV2, MAPK3, BTK, NFKBIE, GRB2, PTPN6, SOS1, VAV3, GSK3B, PIK3CD, SYK, PIK3AP1, CD81, RAC3, PLCG2, PPP3R1",0.518557371497695,0.161780778092374,FALSE
+"HCC44","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.33855,-0.998,0.429,6461,0.644,"ATP2B2, ATP2B4, VDAC3, TACR1, ATP2A1, PHKA2, PLCB1, SLC25A4, NOS1, SLC8A1, PLCB2, GNAQ, P2RX7, PPP3CC, CAMK2B, ADCY9, PLCB3, ITPKB, GNA11, CAMK2D, ERBB2, GRIN1, PLCG1, PLCD1, ATP2A3, CALM2, ERBB3, PLCG2, CALML3, PPP3R1, PLCB4",0.367542707815276,0.191114132640188,FALSE
+"HCC44","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.38684,-1.12,0.279,6095,0.689,"COX6B1, CYC1, CACNA1F, ATP1B1, UQCRFS1, COX5B, ATP1A4, TPM4, UQCRQ, MYH7, SLC8A1, ATP1A1, ATP1A3, COX5A, TPM1, TPM3, SLC9A1, CACNA2D1",0.554395796726402,0.161780778092374,FALSE
+"HCC44","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.56324,-1.62,0.0465,8461,0.448,"PTPRC, CD99, NRCAM, SDC1, CDH15, CDH3, CD276, ITGA6, VCAN, SDC4, ITGA4, PTPRF, NCAM1, NECTIN1, CADM1, SDC2, CDH4, CDH2, ITGB8, JAM3, CNTNAP2",1.33254704711005,0.348721986001856,FALSE
+"HCC44","Input","KEGG_CELL_CYCLE",-0.24385,-0.717,0.813,6921,0.92,"CDC25C, WEE1, CDC45, CDKN1A, CREBBP, CDK2, BUB1B, PLK1, PTTG1, SKP1, YWHAB, CCND1, ANAPC4, CCNB3, CCNA2, CCNB2, TTK, YWHAZ, FZR1, CDC20, BUB1, CHEK1, CCNB1, GSK3B, CDK1, RB1, PKMYT1, TP53",0.0899094544059319,0.0362121726544447,FALSE
+"HCC44","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28983,-0.829,0.632,7044,0.844,"PLCB2, GNG4, PIK3CA, RAF1, AKT2, ADCY9, PLCB3, MAPK1, TIAM2, CCL13, VAV2, MAPK3, GRK2, ARRB2, ARRB1, GRB2, PRKCD, STAT1, CCL14, STAT2, GSK3A, SOS1, VAV3, GRK5, CSK, GSK3B, PIK3CD, PREX1, GRK6, PRKCZ, PLCB4",0.199282921717615,0.073657553374345,FALSE
+"HCC44","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.28494,0.877,0.589,268,0.772,"MYC, TGFB1, CDKN2A, TGFB2, MECOM",0.229884705212898,0.112382699664264,FALSE
+"HCC44","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2745,0.844,0.636,1541,0.787,"SDHA, ACLY, PCK2, SDHD, SDHC, DLST",0.196542884351586,0.104025267640935,FALSE
+"HCC44","Input","KEGG_COLORECTAL_CANCER",0.30816,0.961,0.45,181,0.711,"RAC2, MYC, JUN, TGFB1, TGFB2",0.346787486224656,0.148130399270234,FALSE
+"HCC44","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.37428,1.14,0.269,399,0.598,"CFB, THBD, PLAUR, SERPINE1, C3, MBL2, PLAU, F8",0.570247719997592,0.223298816011589,FALSE
+"HCC44","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.37767,1.19,0.238,2642,0.625,"CTH, BHMT, CBS, AHCYL1, MAT2B, GOT2, MPST, AHCYL2, MAT1A, SDS, MAT2A, MTAP",0.623423042943488,0.204119982655925,FALSE
+"HCC44","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33436,1.01,0.381,546,0.658,"CXCL5, CD40, TGFB1, TNFRSF10B, VEGFA, TGFB2, BMPR2, EPO, CSF1",0.419075024324381,0.181774106386044,FALSE
+"HCC44","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26539,0.811,0.668,1093,0.812,"NFKB1, IRF3, PYCARD, POLR3G, CASP1",0.175223537524454,0.0904439707588247,FALSE
+"HCC44","Input","KEGG_DILATED_CARDIOMYOPATHY",0.29172,0.884,0.626,846,0.785,"DES, TGFB1, TGFB2, ITGA1, ITGA2, LAMA2, ITGA3, ITGB3, ITGB1, GNAS, ITGA5",0.20342566678957,0.105130343254747,FALSE
+"HCC44","Input","KEGG_DNA_REPLICATION",0.23591,0.739,0.792,4125,0.871,"RNASEH2A, SSBP1, RNASEH2B, RFC1, RFC3, RPA1, MCM3, POLD3, MCM6, MCM2, MCM5, RPA2, POLD1, RFC4, RFC2, MCM7, POLD2, MCM4, RPA3, POLE3, RNASEH1, RFC5",0.101274818410506,0.0599818449923368,FALSE
+"HCC44","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.43405,-1.27,0.198,7376,0.579,"MAPK1, MAPK3, GRB2, SOS1, NOTCH3",0.703334809738469,0.237321436272564,FALSE
+"HCC44","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.54485,-1.59,0.0599,7126,0.425,"GSTM3, GSTT2, ALDH3A1, MAOB, MAOA, MGST2, ADH4, ADH7, MGST3, GSTM1, ADH5, GSTP1, GSTM4",1.22257317761069,0.371611069949688,FALSE
+"HCC44","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.45365,1.38,0.128,1597,0.46,"CDA, UPP1, TYMP, NAT2, GMPS, HPRT1, GUSB, NAT1, TPMT",0.892790030352132,0.337242168318426,FALSE
+"HCC44","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.38056,-1.11,0.301,7550,0.676,"SPP1, LAMA3, LAMA4, HMMR, ITGB4, TNXB, CD36, COL1A2, DAG1, VTN, ITGB6, SDC1, ITGA6, FN1, COL1A1, ITGA11, COL3A1, SDC4, ITGA4, SDC2, THBS1, SV2B, ITGB8",0.521433504406157,0.170053304058364,FALSE
+"HCC44","Input","KEGG_ENDOCYTOSIS",-0.29762,-0.883,0.582,6737,0.77,"CHMP5, HSPA1A, EPS15, TSG101, VPS4B, EHD2, CHMP2A, CHMP2B, ARFGAP2, VPS37C, VPS4A, VPS37A, RNF41, STAM2, RAB11FIP1, GRK2, ARRB2, ARRB1, DAB2, IQSEC2, RAB5B, SMAP1, GIT1, SH3GLB2, ASAP1, RAB11A, SMURF2, HSPA2, AGAP1, RAB4A, PARD6G, SRC, HSPA1L, GRK5, EPN3, ASAP3, ERBB3, GRK6, KIT, PRKCZ, SH3GL2, MVB12B",0.235077015350112,0.113509274827518,FALSE
+"HCC44","Input","KEGG_ENDOMETRIAL_CANCER",-0.48139,-1.44,0.09,7099,0.6,"PIK3CA, RAF1, AKT2, CASP9, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, ERBB2, CDH1, BAD, CTNNA2, SOS1, CTNNA1, PDPK1, CTNNB1, GSK3B, PIK3CD, TP53, LEF1",1.04575749056068,0.221848749616356,FALSE
+"HCC44","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.40431,-1.15,0.275,5983,0.677,"RELA, ATP6AP1, PTPN11, ATP6V0A2, LYN, MAPK10, ADAM17, IKBKB, ATP6V0D1, CASP3, ATP6V1B2, ATP6V1A, ATP6V1E1, MAPK14, ATP6V1B1, ATP6V0A1, ADAM10, ATP6V1C2, MAPK13, ATP6V1H, ATP6V1F, MAPK12, GIT1, ATP6V1C1, ATP6V1D, F11R, PLCG1, PTPRZ1, SRC, CSK, PLCG2, JAM3",0.560667306169737,0.169411331314856,FALSE
+"HCC44","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.33069,-0.963,0.446,7099,0.68,"PIK3CA, RAF1, CDKN1A, CAMK2B, AKT2, PAK4, MAPK1, MAPK3, CAMK2D, GRB2, ERBB2, BAD, PLCG1, SOS1, SRC, NCK2, PAK5, PAK6, GSK3B, PIK3CD, AREG, ERBB3, EIF4EBP1, PLCG2",0.350665141287858,0.167491087293764,FALSE
+"HCC44","Input","KEGG_ETHER_LIPID_METABOLISM",0.44664,1.41,0.11,1947,0.442,"PLA2G4A, PLPP3, LPCAT1, PLD1, PLA2G12A, CHPT1, PLPP2",0.958607314841775,0.354577730650908,FALSE
+"HCC44","Input","KEGG_FATTY_ACID_METABOLISM",-0.36034,-1.07,0.323,8430,0.658,"ADH4, ADH7, ACADS, ACSL1, ADH5, ACSL6",0.490797477668897,0.181774106386044,FALSE
+"HCC44","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.35271,-1.04,0.373,6863,0.6,"MAPK14, GAB2, PIK3CA, RAF1, AKT2, MAPK13, MAPK1, VAV2, MAPK3, BTK, MAPK12, GRB2, PRKCD, PLCG1, SOS1, MAP2K6, VAV3, PDPK1, PIK3CD, SYK, RAC3, PLCG2",0.428291168191312,0.221848749616356,FALSE
+"HCC44","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.27993,-0.812,0.671,7099,0.834,"PIK3CA, RAF1, LIMK2, AKT2, MAPK1, PLPP1, VAV2, MAPK3, MYO10, ARPC1A, ASAP1, PRKCD, PLCG1, VAV3, PTPRC, SCIN, WASF3, MARCKSL1, PIK3CD, SYK, ASAP3, GSN, PLCG2",0.173277479831008,0.0788339493622613,FALSE
+"HCC44","Input","KEGG_FOCAL_ADHESION",0.27716,0.846,0.638,986,0.796,"RAC2, FLNC, JUN, LAMC2, VEGFA, COL4A1, ZYX, ITGA1, LAMB3, LAMB1, ITGA2, CAV2, FLNB, ACTN1, COL4A2, LAMA2, ACTN4, ITGA3, ITGB3, COL6A1, FLNA, BIRC2, ACTN2, ITGB1, ITGA5, VCL, MYLK, MYL12A, MYL9, COL6A2",0.195179321278838,0.0990869322623309,FALSE
+"HCC44","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.64236,-1.88,0.0175,8355,0.298,"DHFR, GCH1, ALPI, ALPP",1.75696195131371,0.525783735923745,FALSE
+"HCC44","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.53878,-1.56,0.0776,6785,0.413,"PFKL, ALDOA, AKR1B10, MTMR6, HK1, PFKFB2, MPI, PFKFB4, ALDOC, FBP1, ALDOB, KHK",1.11013827874181,0.384049948343599,FALSE
+"HCC44","Input","KEGG_GALACTOSE_METABOLISM",-0.2428,-0.711,0.832,7781,0.909,"HK1, GAA, GALT",0.0798766737092761,0.0414361167780325,FALSE
+"HCC44","Input","KEGG_GAP_JUNCTION",-0.26558,-0.768,0.771,7044,0.865,"PLCB2, GNAQ, RAF1, CSNK1D, ADCY9, PLCB3, MAPK1, MAPK3, GNA11, GRB2, SOS1, SRC, CDK1, PLCB4",0.112945621949043,0.0629838925351858,FALSE
+"HCC44","Input","KEGG_GLIOMA",-0.42945,-1.27,0.18,7099,0.579,"PIK3CA, RAF1, CDKN1A, CAMK2B, AKT2, MAPK1, MAPK3, CCND1, CAMK2D, GRB2, PLCG1, SOS1, PIK3CD, CALM2, RB1, PLCG2, CALML3, TP53",0.744727494896694,0.237321436272564,FALSE
+"HCC44","Input","KEGG_GLUTATHIONE_METABOLISM",-0.37557,-1.1,0.311,7126,0.667,"GSTM3, GSTT2, IDH2, RRM2, PGD, IDH1, GPX2, MGST2, MGST3, OPLAH, GSTM1, RRM2B, GSTP1, GSTM4",0.507239610973163,0.175874166083451,FALSE
+"HCC44","Input","KEGG_GLYCEROLIPID_METABOLISM",0.24485,0.752,0.724,1947,0.873,"PLPP3, GPAT3, ALDH2, GK, DGKE, ALDH1B1, AGK, AGPAT1, PLPP2",0.140261433802853,0.0589857562944303,FALSE
+"HCC44","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.3003,0.919,0.495,2217,0.77,"PLA2G4A, PLPP3, GPAT3, LPCAT1, MBOAT7, PLD1, PTDSS2, DGKE, PLA2G12A, CDS1, CHPT1, AGPAT1, PLPP2, PTDSS1, AGPAT2",0.305394801066431,0.113509274827518,FALSE
+"HCC44","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.33536,-0.986,0.428,7499,0.657,"MAOB, GAMT, PHGDH, MAOA, GLDC, GATM, SARDH",0.368556230986828,0.182434630440219,FALSE
+"HCC44","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.44793,-1.33,0.148,8430,0.567,"ADH4, ADH7, ALDOC, ACSS2, FBP1, ALDOB, ADH5, ACSS1, PGAM2",0.829738284605043,0.246416941107093,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.44936,1.37,0.145,2434,0.416,"DSE, CHST12, CHST7, B3GALT6, CHPF, CHSY3",0.838631997765025,0.380906669373257,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35868,-1.04,0.359,5526,0.6,"EXTL2, B3GAT3, GLCE, NDST1, HS2ST1, EXTL3, EXT2",0.444905551421681,0.221848749616356,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.51964,1.61,0.0661,826,0.347,"ST3GAL2, B4GALT1, FUT8",1.17979854051436,0.459670525209126,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.32816,1.01,0.359,1110,0.658,"IDS, IDUA, GUSB, NAGLU",0.444905551421681,0.181774106386044,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.37161,1.18,0.23,2769,0.622,"ST3GAL2, SLC33A1, HEXA, GLB1",0.638272163982407,0.206209615309181,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.38117,1.19,0.231,2169,0.625,"ST3GAL2, B3GALNT1, HEXA",0.636388020107856,0.204119982655925,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.38501,1.2,0.223,820,0.65,"FUT4, B4GALT1",0.651695136951839,0.187086643357144,FALSE
+"HCC44","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.24229,-0.714,0.836,5223,0.915,"PIGG, PIGS, PIGK, PIGH, PIGO, PIGT, GPAA1, PIGU, PIGQ, PGAP1",0.0777937225609836,0.0385789059335517,FALSE
+"HCC44","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.34536,1.06,0.347,2243,0.651,"MTHFD2, MTHFD1L, MTHFD1",0.459670525209126,0.186419011431808,FALSE
+"HCC44","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.29929,-0.869,0.594,6782,0.788,"PLCB1, MAP3K3, MAPK14, PLCB2, GNAQ, RAF1, CAMK2B, MAPK13, ADCY9, PLCB3, MAPK1, MAP3K4, MAPK3, GNA11, MAPK12, CAMK2D, GRB2, PRKCD, SOS1, MAP2K6, SRC, CGA, CALM2, CALML3, PLCB4",0.226213555018806,0.103473782510445,FALSE
+"HCC44","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.35594,-1.06,0.362,6848,0.64,"CSNK1G3, WNT5A, BTRC, CSNK1E, SUFU, CSNK1D, WNT11, CSNK1G1, CSNK1A1, BMP6, GSK3B",0.441291429466834,0.193820026016113,FALSE
+"HCC44","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.52514,1.63,0.0591,846,0.349,"ANPEP, CD37, ITGA1, CD44, ITGA2, EPO, CSF1, CD38, ITGA3, ITGB3, CD55, ITGA5",1.22841251911874,0.45717457304082,FALSE
+"HCC44","Input","KEGG_HISTIDINE_METABOLISM",0.33112,1.01,0.378,677,0.658,"ALDH1A3, ALDH2, ALDH3B1",0.422508200162775,0.181774106386044,FALSE
+"HCC44","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.26237,0.812,0.672,3877,0.823,"SSBP1, RAD50, NBN, TOP3B, RPA1, EME1, POLD3, MRE11, RPA2, POLD1, POLD2, RPA3",0.172630726946175,0.0846001647877302,FALSE
+"HCC44","Input","KEGG_HUNTINGTONS_DISEASE",0.17395,0.546,0.99,3114,1,"SOD2, TGM2, SDHA, POLR2I, ATP5MC2, NDUFA10, NDUFA7, SDHD, POLR2K, SDHC, NDUFC1, NDUFV3, TBP, AP2A1, UQCRH, RCOR1, NDUFS6, NDUFS5, AP2B1, NDUFB7, AP2S1, PPID, DNAL1, TFAM, NDUFS3, NDUFA3, NDUFA5, NDUFV1, CYCS, ITPR1, HAP1, GPX1, AP2A2, NDUFB4, NDUFS8, VDAC1, IFT57, HDAC2, NDUFA2, NDUFB9, NDUFA8, BAX, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1, AP2M1, DLG4, DCTN1",0.00436480540245009,0,FALSE
+"HCC44","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.33486,-0.98,0.458,7785,0.657,"TPM1, PRKAG1, ITGB4, TPM3, IL6, DAG1, SGCB, ACE, ITGB6, ITGA6, ITGA11, SGCG, CACNA2D1, ITGA4, ITGB8",0.339134521996131,0.182434630440219,FALSE
+"HCC44","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.43038,-1.29,0.179,6671,0.579,"PI4KA, PLCB1, PIP4K2C, PLCB2, PIK3CA, INPP1, PI4KB, PLCB3, ITPKB, IMPA2, INPPL1, PLCG1, ISYNA1, PLCD1, INPP5A, PIK3CD, PLCG2, PLCB4",0.747146969020107,0.237321436272564,FALSE
+"HCC44","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.31983,-0.941,0.465,6396,0.712,"SHC1, ELK1, PIK3R1, PYGB, PIK3R2, IRS1, GYS1, RAPGEF1, EIF4E2, PHKA2, INSR, PTPN1, PIK3CA, TSC2, FASN, RAF1, AKT2, MAPK1, PRKAA1, MAPK3, GRB2, HK1, PRKAG1, PRKAR2B, BAD, SOS1, PDPK1, GSK3B, PIK3CD, CALM2, PTPRF, EIF4EBP1, PDE3A, FBP1, CALML3, PRKCZ",0.332547047110046,0.147520006363144,FALSE
+"HCC44","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.52442,1.66,0.0481,102,0.343,"CD40, TGFB1",1.31785492362617,0.464705879957229,FALSE
+"HCC44","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.30632,-0.905,0.538,6961,0.749,"IL10RB, TYK2, PIK3CA, AKT2, CREBBP, STAM2, CCND1, IFNGR1, IL13RA1, GRB2, OSM, PTPN6, STAT1, STAT2, PIAS1, IL6, SOS1, LIFR, IFNAR1, IL13RA2, IL6ST, PIK3CD",0.269217724333611,0.125518182300534,FALSE
+"HCC44","Input","KEGG_LEISHMANIA_INFECTION",0.55087,1.78,0.0284,281,0.488,"ITGB2, PTGS2, JUN, TGFB1, CYBA, TGFB2, C3, NCF2",1.54668165995296,0.311580177997289,FALSE
+"HCC44","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.32492,1.01,0.422,961,0.658,"RAC2, ITGB2, ICAM1, CYBA, CLDN11, NCF2, MSN, ACTN1, ACTN4, ACTN2, ITGB1, VCL, MYL12A, MYL9",0.374687549038326,0.181774106386044,FALSE
+"HCC44","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.53891,1.67,0.0283,1312,0.364,"ALDH2, EHHADH, YOD1, ALDH1B1",1.54821356447571,0.438898616350944,FALSE
+"HCC44","Input","KEGG_LONG_TERM_DEPRESSION",-0.26772,-0.782,0.722,6096,0.85,"LYN, GNAI3, ARAF, GNAI1, PPP2CA, PLCB1, NOS1, GNA13, PLCB2, GNAQ, RAF1, PLCB3, MAPK1, MAPK3, GNA11, GNA12, GNAO1, PLCB4",0.141462802430361,0.0705810742857073,FALSE
+"HCC44","Input","KEGG_LONG_TERM_POTENTIATION",-0.36226,-1.09,0.31,6646,0.645,"RPS6KA1, EP300, PLCB1, RPS6KA6, PLCB2, GNAQ, RAF1, PPP3CC, CAMK2B, CREBBP, PLCB3, MAPK1, MAPK3, CAMK2D, GRIN1, CALM2, CALML3, PPP3R1, PLCB4",0.508638306165727,0.190440285364732,FALSE
+"HCC44","Input","KEGG_LYSINE_DEGRADATION",0.24475,0.751,0.759,1718,0.862,"PLOD2, ALDH2, AASS, SETD7, EHHADH, ALDH1B1, PLOD1, PLOD3, DLST, GCDH",0.11975822410452,0.0644927341752872,FALSE
+"HCC44","Input","KEGG_LYSOSOME",-0.20812,-0.595,0.956,6740,0.984,"GLA, SMPD1, ACP5, ATP6V0A1, PSAP, AP3M2, CLN3, NPC2, HGSNAT, ATP6V1H, CTSA, AP1S2, SLC11A2, NAGA, CD63, SORT1, AP4E1, SCARB2, LIPA, ASAH1, LAPTM4B, AP1M2, ABCA2, NEU1, CTSF, GAA, GM2A, AP3B2, CTSH, GALC",0.0195421077238999,0.00700490156865849,FALSE
+"HCC44","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.3273,1,0.39,502,0.662,"RAC2, MYC, FLNC, JUN, ATF4, PLA2G4A, TGFB1, TGFB2, NFKB2, RELB, MECOM, MKNK1, FLNB, MOS, FGF13, FGF2, ELK4, DDIT3",0.408935392973501,0.1791420105603,FALSE
+"HCC44","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.72348,2.28,0.00253,1780,0.176,"IAPP, GCK, HES1, FOXA2",2.59687947882418,0.75448733218585,TRUE
+"HCC44","Input","KEGG_MELANOGENESIS",-0.55602,-1.62,0.0583,6694,0.448,"EP300, PLCB1, WNT5A, FZD1, PLCB2, GNAQ, RAF1, CAMK2B, CREBBP, WNT11, ADCY9, PLCB3, MAPK1, TCF7L2, TCF7L1, MAPK3, CAMK2D, FZD6, CTNNB1, GSK3B, CALM2, GNAO1, KIT, CALML3, PLCB4, LEF1",1.23433144524099,0.348721986001856,FALSE
+"HCC44","Input","KEGG_MELANOMA",-0.34994,-1.04,0.372,7099,0.6,"PIK3CA, RAF1, CDKN1A, AKT2, MAPK1, MAPK3, CCND1, CDH1, BAD, HGF, PIK3CD, RB1, FGFR1, TP53",0.429457060118102,0.221848749616356,FALSE
+"HCC44","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.58979,-1.71,0.0385,7957,0.375,"AKR1C2, AKR1C3, AKR1C1, EPHX1, MGST2, ADH4, ADH7, MGST3, CYP1A1, GSTM1, ADH5, GSTP1, GSTM4",1.4145392704915,0.425968732272281,FALSE
+"HCC44","Input","KEGG_MISMATCH_REPAIR",0.36698,1.14,0.251,3877,0.598,"SSBP1, MLH1, MSH3, RFC1, RFC3, PMS2, RPA1, POLD3, MSH2, RPA2, POLD1, RFC4, RFC2, POLD2, RPA3",0.600326278518962,0.223298816011589,FALSE
+"HCC44","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.39091,-1.16,0.247,5532,0.691,"AKT1, RPS6KA3, RPS6KB2, RPS6KA2, BRAF, RPS6KB1, PIK3CB, RICTOR, STRADA, PIK3R1, PIK3R2, RPS6KA1, CAB39, EIF4E2, RPS6KA6, PIK3CA, TSC2, AKT2, ULK1, MAPK1, PRKAA1, MAPK3, CAB39L, PDPK1, PIK3CD, EIF4EBP1",0.607303046740334,0.160521952625802,FALSE
+"HCC44","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.29373,0.914,0.498,140,0.766,"RAC2, ITGB2, ICAM1, TNFRSF10B",0.302770657240282,0.115771230367396,FALSE
+"HCC44","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.28383,-0.842,0.645,7533,0.829,"CHRNE, GRIN1, PLG, F2, CGA, HCRTR1",0.190440285364732,0.0814454694497265,FALSE
+"HCC44","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.3974,-1.17,0.239,6584,0.708,"PIK3R2, IRS1, RAPGEF1, RPS6KA1, GAB1, MAP3K3, MAPK14, RPS6KA6, SH2B1, PIK3CA, RAF1, CAMK2B, AKT2, MAPK13, MAPK1, YWHAB, MAPK3, MAPK12, NFKBIE, CAMK2D, GRB2, YWHAZ, SORT1, PRKCD, BAD, PLCG1, SOS1, MAPKAPK2, PDPK1, FRS2, CSK, GSK3B, PIK3CD, CALM2, BCL2, MAGED1, PLCG2, ARHGDIB, CALML3, TP53, TP73, NGFR",0.621602099051862,0.149966742310231,FALSE
+"HCC44","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38997,1.17,0.245,806,0.62,"NAMPT, NT5E, NNMT, PNP, CD38, ENPP1",0.610833915635468,0.207608310501746,FALSE
+"HCC44","Input","KEGG_NITROGEN_METABOLISM",-0.68798,-1.96,0.0133,8712,0.243,"GLUL, CA3, GLUD2",1.87614835903291,0.614393726401688,TRUE
+"HCC44","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.19739,-0.582,0.961,7323,0.982,"MAPK13, MAPK1, CCL13, MAPK3, MAPK12, CASP8, IL6, CARD8, TAB3",0.0172766123314547,0.00788851221305034,FALSE
+"HCC44","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.33699,1.03,0.386,3676,0.679,"XRCC4, XRCC5, RAD50, LIG4, MRE11, XRCC6, DCLRE1C, PRKDC",0.413412695328245,0.168130225719498,FALSE
+"HCC44","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.3733,-1.09,0.331,7099,0.645,"PIK3CA, RAF1, AKT2, CASP9, MAPK1, RXRA, MAPK3, CCND1, GRB2, ERBB2, RXRG, BAD, PLCG1, SOS1, PDPK1, PIK3CD, RB1, PLCG2, TP53",0.480172006224281,0.190440285364732,FALSE
+"HCC44","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.54645,-1.58,0.0664,7246,0.41,"CREBBP, LFNG, MAML2, NCSTN, DLL1, APH1A, DLL3, JAG1, DTX3L, NOTCH3, DLL4",1.17783192063198,0.387216143280265,FALSE
+"HCC44","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.1578,0.495,0.992,7687,0.995,"ERCC2, GTF2H2, CCNH, GTF2H1, GTF2H3, GTF2H4, MNAT1, RFC1, RFC3, RPA1, POLD3, XPA, ERCC5, RPA2, POLD1, RFC4, RFC2, POLD2, RAD23A, RPA3, CDK7, POLE3, RFC5, POLD4, POLE4, ERCC4, CUL4A, ERCC3, LIG1, PCNA, CUL4B, DDB2, RAD23B, GTF2H5, DDB1, XPC, POLE, ERCC6, CETN2",0.00348832784582135,0.00217691925427455,FALSE
+"HCC44","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.40193,-1.15,0.274,9117,0.677,"MAN1C1",0.562249437179612,0.169411331314856,FALSE
+"HCC44","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.57695,-1.71,0.0392,7230,0.375,"CAMK2B, ARRB2, CAMK2D, CLCA2, CALM2, CALML3",1.40671393297954,0.425968732272281,FALSE
+"HCC44","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.36623,1.16,0.238,2243,0.599,"MTHFD2, MTHFR, SHMT2, MTHFD1L, GART, MTFMT, MTHFD1",0.623423042943488,0.222573177610689,FALSE
+"HCC44","Input","KEGG_OOCYTE_MEIOSIS",-0.44054,-1.3,0.159,6898,0.58,"PPP2R5A, CDC25C, RPS6KA6, BTRC, PPP2R5D, PPP2R5B, PPP3CC, CAMK2B, ADCY9, CDK2, MAPK1, AURKA, PLK1, PTTG1, SKP1, YWHAB, MAPK3, ANAPC4, CCNB2, MAPK12, SGO1, CAMK2D, YWHAZ, CDC20, BUB1, CCNB1, CDK1, FBXO5, CALM2, PKMYT1, CALML3, PPP3R1",0.798602875679548,0.236572006437063,FALSE
+"HCC44","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.46926,1.43,0.119,2769,0.489,"FUCA1, FUCA2, MAN2B2, MAN2B1, MANBA, HEXA, ENGASE, GLB1",0.924453038607469,0.31069114087638,FALSE
+"HCC44","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.17295,0.535,0.995,3054,1,"COX11, SDHA, ATP5MC2, COX17, TCIRG1, NDUFA10, NDUFA7, SDHD, SDHC, NDUFC1, NDUFV3, UQCRH, NDUFS6, NDUFS5, NDUFB7, NDUFA11, NDUFS3, NDUFA3, NDUFA5, ATP5ME, NDUFV1, NDUFB4, NDUFS8, NDUFA2, NDUFB9, NDUFA8, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1",0.00217691925427455,0,FALSE
+"HCC44","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.55789,1.73,0.0367,1574,0.422,"GALNT14, GALNT11, GALNT6, ST3GAL2, C1GALT1, GALNT15, C1GALT1C1, GALNT16, GALNT17",1.43533393574791,0.374687549038326,FALSE
+"HCC44","Input","KEGG_P53_SIGNALING_PATHWAY",-0.39537,-1.16,0.247,7115,0.691,"TSC2, FAS, CDKN1A, CDK2, CASP9, RRM2, CCND1, CCNB3, COP1, CCNB2, CASP8, CHEK1, CCNB1, IGFBP3, CDK1, THBS1, RRM2B, TP53, TP73",0.607303046740334,0.160521952625802,FALSE
+"HCC44","Input","KEGG_PANCREATIC_CANCER",0.33514,1.06,0.328,181,0.651,"RAC2, TGFB1, CDKN2A, TGFA, VEGFA, TGFB2",0.484126156288321,0.186419011431808,FALSE
+"HCC44","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.32182,-0.939,0.501,6600,0.706,"PPCDC, BCAT2, PANK2, DPYD, PPCS",0.300162274132754,0.151195298948196,FALSE
+"HCC44","Input","KEGG_PARKINSONS_DISEASE",0.20479,0.628,0.957,3177,0.985,"UCHL1, SDHA, UBE2J2, ATP5MC2, NDUFA10, NDUFA7, SDHD, SDHC, NDUFC1, NDUFV3, UQCRH, NDUFS6, NDUFS5, NDUFB7, SLC18A1, PPID, NDUFS3, NDUFA3, NDUFA5, NDUFV1, CYCS, NDUFB4, NDUFS8, PARK7, VDAC1, NDUFA2, NDUFB9, NDUFA8, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1, HTRA2, NDUFC2",0.0190880622231565,0.00656376950238827,FALSE
+"HCC44","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.17262,-0.517,0.981,7725,0.999,"YWHAZ, CDH1, ARPC1A, NCK2, CTNNB1",0.0083309926200515,0.000434511774017692,FALSE
+"HCC44","Input","KEGG_PATHWAYS_IN_CANCER",0.29139,0.904,0.539,654,0.773,"RAC2, PTGS2, TRAF1, SMO, MYC, MMP1, JUN, TGFB1, CDKN2A, TGFA, LAMC2, VEGFA, TGFB2, COL4A1, NFKB2, MECOM, LAMB3, LAMB1, ITGA2, COL4A2, FGF13, FGF2, LAMA2, ITGA3, NFKB1",0.268411234813261,0.111820506081675,FALSE
+"HCC44","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.27016,-0.801,0.709,6692,0.845,"XYLB, RPE, CRYL1, DCXR",0.149353764816933,0.0731432910503077,FALSE
+"HCC44","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.2787,-0.824,0.676,8757,0.831,"ALDOC, FBP1, ALDOB",0.170053304058364,0.080398976215889,FALSE
+"HCC44","Input","KEGG_PEROXISOME",-0.35755,-1.06,0.357,7202,0.64,"PEX11A, PECR, IDH2, NUDT12, PRDX5, SLC27A2, ACOX1, IDH1, PMVK, PXMP4, CROT, PHYH, EPHX2, AMACR, ACSL1, MVK, FAR1, ACSL6",0.447331783887807,0.193820026016113,FALSE
+"HCC44","Input","KEGG_PHENYLALANINE_METABOLISM",-0.3629,-1.04,0.364,7308,0.6,"ALDH3A1, PRDX6, MAOB, MAOA, TAT, DDC",0.438898616350944,0.221848749616356,FALSE
+"HCC44","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.35587,-1.03,0.385,6489,0.598,"PIK3R1, PIK3R2, PI4KA, PLCB1, PIP4K2C, DGKZ, PLCB2, PIK3CA, INPP1, PI4KB, PLCB3, DGKD, ITPKB, IMPA2, INPPL1, PLCG1, PLCD1, INPP5A, PIK3CD, CALM2, PLCG2, CALML3, PLCB4",0.414539270491499,0.223298816011589,FALSE
+"HCC44","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.26804,-0.783,0.71,7116,0.858,"BLVRA, COX15, HMOX1, ALAD, BLVRB, FTH1",0.148741651280925,0.0665127121512946,FALSE
+"HCC44","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.42759,-1.25,0.216,7011,0.58,"SLC27A1, UBC, OLR1, RXRA, ANGPTL4, SLC27A2, FABP3, ACOX1, FADS2, RXRG, CD36, FABP4, PDPK1, CYP27A1, SCD, SCD5, FABP7, LPL, APOC3, ACSL1, ACSL6",0.665546248849069,0.236572006437063,FALSE
+"HCC44","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.48641,1.53,0.0665,871,0.428,"CD40, RFXAP, RFX5, TAP2",1.1771783546969,0.368556230986828,FALSE
+"HCC44","Input","KEGG_PRION_DISEASES",-0.31073,-0.914,0.494,6344,0.742,"NOTCH1, ELK1, STIP1, HSPA1A, MAPK1, LAMC1, MAPK3, C9, IL6, NCAM1",0.306273051076353,0.129596094720973,FALSE
+"HCC44","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.46332,-1.34,0.143,5532,0.571,"AKT1, RPS6KA3, MAPK9, HSP90AA1, RPS6KA2, BRAF, GNAI2, KRAS, PIK3CB, MAD2L1, ANAPC7, MAPK10, GNAI3, ARAF, ADCY5, GNAI1, PIK3R1, PIK3R2, RPS6KA1, MAPK14, CDC25C, RPS6KA6, PIK3CA, RAF1, AKT2, MAPK13, ADCY9, CDK2, MAPK1, PLK1, MAPK3, ANAPC4, CCNB3, CCNA2, CCNB2, MAPK12, FZR1, BUB1, CCNB1, PIK3CD, CDK1, PDE3A, PKMYT1",0.844663962534938,0.243363891754152,FALSE
+"HCC44","Input","KEGG_PROPANOATE_METABOLISM",-0.37351,-1.1,0.311,8834,0.667,"ACSS2, ABAT, ACSS1",0.507239610973163,0.175874166083451,FALSE
+"HCC44","Input","KEGG_PROSTATE_CANCER",-0.47638,-1.42,0.109,7099,0.608,"PIK3CA, RAF1, CDKN1A, AKT2, CREBBP, CDK2, CASP9, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, ERBB2, BAD, SOS1, PDPK1, CTNNB1, GSK3B, PIK3CD, BCL2, RB1, FGFR1, GSTP1, TP53, LEF1",0.962573502059376,0.216096420727265,FALSE
+"HCC44","Input","KEGG_PROTEASOME",0.58921,1.72,0.0351,3061,0.339,"PSMB10, PSMB9, PSMB8, PSME1, PSMA6, PSME4, PSMB4, PSMC2, PSME2, PSME3, PSMD2, PSMA4, PSMC1, PSMB3, PSMC5, PSMA3, PSMA8, PSMD8, PSMD13, PSMD4, PSMA5, PSMD1, PSMD12, PSMC4, PSMA7, PSMD14, PSMD11, PSMC6, PSMA1, PSMD6, PSMC3, PSMD7, PSMF1, PSMB1, PSMB2, PSMD3",1.45469288353418,0.469800301796918,FALSE
+"HCC44","Input","KEGG_PROTEIN_EXPORT",0.34728,1.07,0.331,3320,0.667,"SEC61B, SEC61A1, SRP19, SRP72, SEC62, HSPA5, SRPRA, SRP68, OXA1L, SPCS1, SRP54, SEC63, SRPRB",0.480172006224281,0.175874166083451,FALSE
+"HCC44","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.59487,-1.75,0.0312,9114,0.453,"GLUD2",1.50584540598156,0.343901797987168,FALSE
+"HCC44","Input","KEGG_PURINE_METABOLISM",0.26579,0.792,0.675,1982,0.812,"FHIT, NT5E, POLR2I, PNP, PNPT1, ENPP1, AK4, GMPS, PFAS, HPRT1, POLR3G, PAICS, PRPS1, PRPS1L1, PDE6C, POLR1E, ADSL, POLR2K, GART, PPAT, GDA, NME7, DGUOK, PDE4D, NUDT5, GMPR2, APRT, ADK, PDE6D, ENTPD4",0.170696227168975,0.0904439707588247,FALSE
+"HCC44","Input","KEGG_PYRIMIDINE_METABOLISM",0.22738,0.71,0.81,1354,0.894,"CDA, NT5E, UPP1, TXNRD1, POLR2I, PNP, TYMP, PNPT1, DHODH, POLR3G, POLR1E, AK3, POLR2K",0.0915149811213502,0.0486624812040823,FALSE
+"HCC44","Input","KEGG_PYRUVATE_METABOLISM",-0.22222,-0.647,0.913,8834,0.965,"ACSS2, ACSS1",0.039529222465701,0.0154726866562074,FALSE
+"HCC44","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.25467,0.792,0.694,961,0.812,"RAC2, ITGB2, ITGA1, CFL2, ITGA2, MSN, MYH9, DIAPH2, ACTN1, MOS, FGF13, FGF2, SSH1, ACTN4, ITGA3, DIAPH3, ITGB3, PIP4K2A, ARHGEF1, ACTN2, ITGB1, LIMK1, ITGA5, VCL, MYLK, MYL12A, MYL9",0.158640529545145,0.0904439707588247,FALSE
+"HCC44","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.47454,-1.4,0.124,6794,0.583,"GABARAPL1, GABARAPL2, ATG4D, ULK1, PRKAA1, ATG4B",0.906578314837765,0.234331445240986,FALSE
+"HCC44","Input","KEGG_RENAL_CELL_CARCINOMA",0.33432,1.03,0.349,181,0.679,"JUN, TGFB1, TGFA, VEGFA, TGFB2",0.45717457304082,0.168130225719498,FALSE
+"HCC44","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.35719,1.1,0.288,1130,0.641,"ANPEP, LNPEP, THOP1",0.540607512240769,0.193141970481183,FALSE
+"HCC44","Input","KEGG_RETINOL_METABOLISM",-0.47464,-1.38,0.136,7497,0.566,"RETSAT, PNPLA4, RDH16, ADH4, ADH7, CYP1A1, ADH5, ALDH1A1",0.866461091629782,0.247183568811729,FALSE
+"HCC44","Input","KEGG_RIBOFLAVIN_METABOLISM",0.46958,1.49,0.0907,806,0.427,"ACP6, ENPP1",1.0423927129399,0.369572124974976,FALSE
+"HCC44","Input","KEGG_RIBOSOME",0.50097,1.52,0.0637,3274,0.412,"RPL37, RPL29, RPL24, RSL24D1, RPS25, RPL11, RPL27, RPL22, RPL18, RPL4, RPL38, RPL12, RPS7, RPL17, RPL32, RPL9, RPL26, RPL37A, RPL28, RPL30, FAU, RPL27A, RPL36, RPL5, RPS27L, MRPL13, RPL13, RPL14, RPL10A, RPS29, RPL3, RPL18A, RPL10, RPL15, RPL35A, RPSA, RPL34, RPL23, RPS16, RPS12, RPLP0, RPL7, RPL36A, RPL36AL, RPL21, RPS11, RPL19, RPL7A, RPS6, RPL23A, RPL13A, RPL6, RPS15A, RPLP1, RPS20, RPS28, RPS21, RPS24, RPS23, RPL35, RPS10, RPL8, RPS3A",1.19586056766465,0.385102783966865,FALSE
+"HCC44","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.16714,-0.491,0.998,5983,0.994,"RELA, MAPK10, IKBKB, MAP3K7, MAP3K1, MAPK14, IFIH1, MAPK13, MAPK12, CASP8, DDX58, FADD, TKFC",0.000869458712628891,0.00261361560268669,FALSE
+"HCC44","Input","KEGG_RNA_DEGRADATION",0.45354,1.37,0.122,1963,0.416,"EXOSC2, EXOSC9, DIS3, EXOSC1, PNPT1, DCPS, EXOSC5, EXOSC8, EXOSC6, EXOSC3, EXOSC7, DCP2, MTREX, EXOSC4, PAPOLA, ZCCHC7, EXOSC10, LSM6, MPHOSPH6, LSM2",0.913640169325252,0.380906669373257,FALSE
+"HCC44","Input","KEGG_RNA_POLYMERASE",0.3448,1.07,0.327,2931,0.667,"POLR2I, POLR3G, POLR1E, POLR2K, POLR3H, POLR1A, POLR3F, POLR3C",0.485452247339714,0.175874166083451,FALSE
+"HCC44","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.54971,1.72,0.0495,2526,0.339,"CTH, GGT1, SCLY, CBS, AHCYL1, MAT2B, MARS2, AHCYL2, MAT1A, BUD23, MAT2A",1.30539480106643,0.469800301796918,FALSE
+"HCC44","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.40313,1.27,0.167,799,0.546,"PTGS2, TRAF1, MYC, FHIT, LAMC2, COL4A1, LAMB3, LAMB1, ITGA2, COL4A2, LAMA2, ITGA3, NFKB1, BIRC2, ITGB1",0.777283528852417,0.262807357295263,FALSE
+"HCC44","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.27597,0.834,0.644,1519,0.793,"STX11, VAMP5, BET1, VAMP3, STX10, STX16, VAMP8",0.191114132640188,0.100726812682396,FALSE
+"HCC44","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.28032,-0.821,0.646,8031,0.827,"ASAH1, DEGS1, NEU1, CERK, SMPD3, GALC",0.189767482004916,0.0824944904474534,FALSE
+"HCC44","Input","KEGG_SPLICEOSOME",0.4694,1.41,0.123,3621,0.442,"HNRNPU, THOC1, TXNL4A, SNRPB, DDX46, PRPF31, U2AF1, SNRNP40, NCBP2, SLU7, THOC2, DHX38, SNRNP70, PRPF40A, U2AF2, SNRPA1, CDC40, SNRPF, THOC3, DDX42, PRPF4, LSM6, PRPF6, NCBP1, RBM22, RBM17, DHX16, DDX39B, SNRPD3, PRPF38A, DDX23, CHERP, SMNDC1, LSM2, ZMAT2, PRPF38B, SNRNP27, SF3B6, SRSF8, ACIN1, ALYREF, RBM25, PPIE, DHX8, SRSF2, SNRPG, PRPF3, SNW1, HNRNPC, SNRPC, EFTUD2, SNRPA, SART1, PRPF8, HNRNPM, LSM8, SNU13, TCERG1, SF3B4, PHF5A, SRSF1, RBM8A, SNRNP200, SNRPD1, SNRPD2, CWC15, EIF4A3, SF3B5, SNRPB2, PQBP1, SF3A3, SF3B2, U2SURP, SF3B3, PRPF19, SRSF7, CTNNBL1, SF3A1, SYF2, BCAS2, SRSF3, HNRNPK, PLRG1, WBP11, HNRNPA3, HNRNPA1, PPIL1, SF3A2, TRA2B, SRSF5, MAGOHB",0.910094888560602,0.354577730650908,FALSE
+"HCC44","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.35956,1.12,0.285,1511,0.619,"PYGL, GCK, ENPP1, GUSB, GBE1, UGDH, UXS1",0.54515513999149,0.208309350979882,FALSE
+"HCC44","Input","KEGG_STEROID_BIOSYNTHESIS",-0.72797,-2.14,0.00326,7448,0.231,"LSS, HSD17B7, DHCR24, CYP51A1, CEL, LIPA, MSMO1, SQLE, SC5D, FDFT1",2.48678239993206,0.636388020107856,TRUE
+"HCC44","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.72218,-2.12,0.0115,7438,0.175,"CYP21A2, HSD17B7, AKR1C2, AKR1D1, AKR1C3, AKR1C1, STS, SULT2B1, CYP1A1, CYP11B1, HSD11B2",1.93930215964639,0.756961951313706,TRUE
+"HCC44","Input","KEGG_SULFUR_METABOLISM",-0.79031,-2.32,0,8714,0.136,"SULT2B1, SUOX, SULT1A1",Inf,0.866461091629782,TRUE
+"HCC44","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.44235,1.37,0.152,1123,0.416,"CD40, C3, ACTN1, ACTN4, ACTN2, SNRPB",0.818156412055227,0.380906669373257,FALSE
+"HCC44","Input","KEGG_TASTE_TRANSDUCTION",-0.3859,-1.11,0.275,8469,0.676,"SCNN1A, ASIC2",0.560667306169737,0.170053304058364,FALSE
+"HCC44","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.69095,-2.01,0.00666,7947,0.235,"IDI1, PMVK, HMGCR, MVK, HMGCS1",2.1765257708297,0.628932137728264,TRUE
+"HCC44","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.25426,-0.741,0.763,7246,0.89,"CREBBP, MAPK1, SKP1, MAPK3, SMAD5, DCN, SMURF2, LTBP1, BMP6, INHBA, ACVR1, FST, THBS1",0.11747546204512,0.0506099933550872,FALSE
+"HCC44","Input","KEGG_THYROID_CANCER",-0.53967,-1.6,0.053,7376,0.441,"MAPK1, RXRA, TCF7L2, TCF7L1, MAPK3, CCND1, CDH1, RXRG, TPM3, CTNNB1, NCOA4, TP53, LEF1",1.27572413039921,0.355561410532161,FALSE
+"HCC44","Input","KEGG_TIGHT_JUNCTION",-0.389,-1.13,0.273,8009,0.702,"F11R, PRKCD, PATJ, TJP3, EPB41L1, CTNNA2, PARD6G, CTNNA1, LLGL2, SRC, CTNNB1, CGN, MPDZ, PRKCH, MYH14, MYH7B, EPB41L3, PRKCZ, CRB3, JAM3",0.563837352959244,0.153662887870195,FALSE
+"HCC44","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.2275,-0.661,0.882,7099,0.959,"PIK3CA, AKT2, MAPK13, MAPK1, SPP1, MAPK3, MAPK12, TOLLIP, CASP8, FADD, STAT1, IL6, MAP2K6, IFNAR1, PIK3CD, TLR3",0.0545314148681803,0.0181813928293364,FALSE
+"HCC44","Input","KEGG_TRYPTOPHAN_METABOLISM",0.28792,0.877,0.554,925,0.772,"KYNU, ALDH2, EHHADH, WARS2",0.25649023527157,0.112382699664264,FALSE
+"HCC44","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.48482,-1.4,0.135,6047,0.583,"PKLR, MAPK10, PKM, IKBKB, PIK3R1, PIK3R2, IRS1, INSR, PIK3CA, MAPK1, MAPK3, HK1, PRKCD, PIK3CD, PRKCZ",0.869666231504994,0.234331445240986,FALSE
+"HCC44","Input","KEGG_TYROSINE_METABOLISM",-0.42058,-1.25,0.208,7308,0.58,"ALDH3A1, LCMT1, MAOB, MAOA, TAT, DDC, ADH4, ADH7, ADH5",0.681936665037238,0.236572006437063,FALSE
+"HCC44","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.45108,-1.34,0.132,7081,0.571,"NFATC2, PIK3CA, RAF1, PPP3CC, TEC, PRKCQ, AKT2, PAK4, MAPK13, MAPK1, VAV2, MAPK3, MAPK12, NFKBIE, GRB2, PTPN6, PLCG1, SOS1, VAV3, PDPK1, PTPRC, NCK2, PAK5, PAK6, GSK3B, PIK3CD, PPP3R1",0.87942606879415,0.243363891754152,FALSE
+"HCC44","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.23239,-0.68,0.881,5967,0.944,"CUL5, UBA2, ANAPC7, UBE2D2, TRIM37, CUL4B, FBXW11, UBE2G1, DDB2, UBE2F, MAP3K1, UBE2J1, CUL3, UBE4B, FBXO2, NHLRC1, BTRC, UBA1, DDB1, SKP1, ANAPC4, COP1, FZR1, CDC20, UBE2R2, CUL7, HERC1, FBXW7, SMURF2, KEAP1, PIAS1, MGRN1, KLHL13, UBE2C",0.0550240915879521,0.025028005701931,FALSE
+"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.28336,-0.827,0.692,7143,0.837,"IARS2, BCAT2",0.159893905543242,0.07727454200674,FALSE
+"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.21887,-0.629,0.912,8659,0.974,"ACADS, ABAT, HMGCS1",0.0400051616715838,0.0114410431213845,FALSE
+"HCC44","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.27061,-0.797,0.684,7010,0.842,"GNA13, PLCB2, GNAQ, RAF1, PRKCQ, ADCY9, PLCB3, MAPK1, ARHGEF12, MAPK3, GNA11, GNA12, KCNMA1, NPR2, ARHGEF11, PRKCD, CALM2, PRKCH, CALML3, PLCB4",0.164943898279884,0.0746879085003505,FALSE
+"HCC44","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.39997,-1.18,0.262,6986,0.706,"DYNLL2, DYNLL1, ADCY9, RAB5B, RAB11A, AVP, AQP3, ARHGDIB",0.581698708680255,0.151195298948196,FALSE
+"HCC44","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.30469,0.923,0.495,170,0.776,"RAC2, PTGS2, PLA2G4A, VEGFA",0.305394801066431,0.110138278741812,FALSE
+"HCC44","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25372,-0.747,0.772,6568,0.89,"KDELR3, ATP6V0D1, ATP6V1B2, ATP6V1A, ATP6V1E1, ATP6V1B1, ATP6V0A1, ATP6V1C2, ADCY9, ATP6V1H, ATP6V1F, ATP6V1C1, ATP6V1D, PLCG1, SLC12A2, PLCG2",0.112382699664264,0.0506099933550872,FALSE
+"HCC44","Input","KEGG_VIRAL_MYOCARDITIS",0.46775,1.42,0.117,670,0.475,"RAC2, ITGB2, ICAM1, CD40, MYH11, MYH9, LAMA2, CD55",0.931814138253838,0.323306390375133,FALSE
+"HCC44","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.31185,-0.901,0.528,6099,0.746,"DVL3, CTBP1, MAPK10, SMAD2, FBXW11, AXIN1, PPP3CB, ROCK1, PPP2R5C, CHD8, MAP3K7, PPP2CA, EP300, PPP2R5E, PLCB1, APC, WNT5A, PPP2R5A, BTRC, CSNK1E, PPP2R5D, FZD1, PLCB2, NFATC2, PPP2R5B, PPP3CC, CAMK2B, CREBBP, WNT11, PLCB3, LRP6, TCF7L2, SKP1, TCF7L1, VANGL1, CCND1, CAMK2D, FZD6, DAAM1, CSNK1A1, CTNNB1, GSK3B, RAC3, VANGL2, PPP3R1, TP53, PLCB4, LEF1",0.277366077466188,0.127261172527331,FALSE
+"H1299","Input","KEGG_ABC_TRANSPORTERS",-0.27599,-0.873,0.599,8317,0.739,"ABCG2, ABCB6, ABCD3, ABCA2, ABCC2",0.222573177610689,0.131355561605174,FALSE
+"H1299","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.24869,-0.785,0.737,6104,0.868,"PIK3R2, RUNX1, KRAS, NRAS, KIT, PIK3R3, BRAF, MAPK3, GRB2, SOS1, STAT3, HRAS, STAT5A, TCF7L2, RPS6KB2, PIM1, TCF7L1, PIK3CD, CCND1, LEF1, CEBPA",0.132532512140949,0.0614802748235081,FALSE
+"H1299","Input","KEGG_ADHERENS_JUNCTION",-0.40719,-1.26,0.196,7299,0.361,"RAC1, PARD3, IGF1R, TCF7L2, WASF2, SRC, SORBS1, CREBBP, TCF7L1, EP300, LMO7, INSR, LEF1, ERBB2, PTPRM, ACTG1, BAIAP2, PTPN6, CTNNB1, CTNND1, NECTIN1, CTNNA1, CTNNA2, RAC2, CDH1",0.707743928643524,0.442492798094342,FALSE
+"H1299","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.34377,-1.09,0.317,8606,0.481,"IRS2, CAMKK1, ACSL1, NFKBIA, RXRG, RXRA, ACSL5, PRKCQ",0.498940737782249,0.317854923626168,FALSE
+"H1299","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.512,-1.61,0.0495,8299,0.19,"GFPT1, GLUL, CPS1, ABAT, ASS1, GLUD2",1.30539480106643,0.721246399047171,TRUE
+"H1299","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.47784,-1.51,0.0708,7168,0.231,"ATP1A3, PDPK1, SFN, ATP1A1, SLC9A3R2, ATP1B3, ATP1A4, PIK3CD, ATP1B1, INSR, IRS2, HSD11B2",1.14996674231023,0.636388020107856,FALSE
+"H1299","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.73163,-2.33,0.00368,8416,0.0412,"PLA2G12A, ACOX1, PLA2G4A, FADS2",2.43415218132648,1.38510278396687,TRUE
+"H1299","Input","KEGG_ALZHEIMERS_DISEASE",0.18642,0.598,0.957,3800,1,"TNFRSF1A, PLCB4, CYC1, BAD, COX6C, NDUFA9, PSEN1, CYCS, NDUFB4, UQCRQ, MME, GAPDH, NDUFS2, CAPN2, CHP1, NDUFB7, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, NDUFA4, NDUFC2, ITPR1, PPP3CC, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, ATP5PO, NDUFA6, NDUFA10, COX4I1, COX6B1, ITPR2, ATP5PB, NDUFB10, NDUFB9, GRIN1, NCSTN, SDHD, COX5A, ADAM17, UQCRC2, FADD, APAF1, NDUFB2, CASP9, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB",0.0190880622231565,0,FALSE
+"H1299","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.35339,1.12,0.292,1225,0.936,"RARS2, DARS2, YARS2, AARS2",0.534617148551582,0.0287241512618947,FALSE
+"H1299","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.26716,-0.834,0.666,7688,0.799,"GMPPA, UGDH, GMDS, HK1, CYB5R1, GFPT1, PGM1, MPI, UXS1, GALT, PMM2, GALE",0.176525770829699,0.0974532206860086,FALSE
+"H1299","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.34158,1.07,0.342,1049,0.872,"NEFH, TNFRSF1A, PRPH, PRPH2, MAP2K3, TOMM40, BAD, NEFM, DAXX, CYCS",0.465973893943865,0.0594835150674328,FALSE
+"H1299","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.31939,-0.993,0.409,7289,0.579,"PSME2, CREB1, CTSB, B2M, PDIA3, PSME1, CANX, CD74, CALR, CTSS, IFI30",0.388276691992658,0.237321436272564,FALSE
+"H1299","Input","KEGG_APOPTOSIS",0.20589,0.655,0.92,1231,1,"TNFRSF1A, RIPK1, TNFRSF10A, IRAK4, BIRC2, ENDOG, BAD, EXOG, CYCS, AKT1, IRAK1",0.0362121726544447,0,FALSE
+"H1299","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.64437,-2.01,0.00737,8030,0.0878,"CBR1, GPX2, ALOX5, GGT1, PLA2G12A, GPX6, GPX7, CYP2J2, PTGS2, PTGES, PLA2G4A, EPHX2, GPX1",2.13253251214095,1.0565054840939,TRUE
+"H1299","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.54637,-1.73,0.0414,7582,0.14,"MAOA, ALDH18A1, PYCR3, OAT, ALDH3A2, GAMT, CKMT2, GLUL, PYCR1, PYCR2, AGMAT, GATM, ARG2, P4HA2, P4HA1, ALDH2, ARG1, MAOB, CPS1, ALDH1B1, ASS1, GLUD2",1.3829996588791,0.853871964321762,TRUE
+"H1299","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.37732,-1.21,0.183,8316,0.387,"ITGAV, LEF1, ACTG1, DSG2, ITGA7, PKP2, CTNNB1, ITGB4, GJA1, DSC2, CTNNA1, SGCD, CTNNA2, ITGB6",0.737548910269571,0.412289034981089,FALSE
+"H1299","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.74763,-2.33,0,7164,0.0412,"ALDH9A1, UGDH, ALDH3A2, ALDH2, ALDH1B1",Inf,1.38510278396687,TRUE
+"H1299","Input","KEGG_AXON_GUIDANCE",-0.4094,-1.29,0.17,8174,0.343,"PLXNB1, DPYSL2, PLXNB2, SEMA7A, SEMA4D, EPHB2, SEMA3A, EFNB2, EPHA1, UNC5B, SEMA6A, EPHA4, L1CAM, RAC2, ABLIM1, ABLIM3, PLXNA2, ABLIM2",0.769551078621726,0.464705879957229,FALSE
+"H1299","Input","KEGG_BASAL_CELL_CARCINOMA",-0.64483,-2.03,0.00929,7556,0.0914,"TCF7L2, FZD7, GSK3B, APC, TCF7L1, SHH, LEF1, WNT16, CTNNB1, SUFU, TP53, WNT11",2.03198428600636,1.03905380426617,TRUE
+"H1299","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.23949,0.769,0.771,3786,1,"TAF2, TBP, GTF2I, TAF9B, GTF2A1, GTF2H4, GTF2A2, TAF6, TAF1, TAF5, TAF13",0.112945621949043,0,FALSE
+"H1299","Input","KEGG_BASE_EXCISION_REPAIR",-0.37405,-1.16,0.26,7169,0.407,"SMUG1, XRCC1, FEN1, NTHL1, LIG1, APEX1, MPG, APEX2, LIG3, PARP1, TDG",0.585026652029182,0.39040559077478,FALSE
+"H1299","Input","KEGG_BETA_ALANINE_METABOLISM",-0.58082,-1.83,0.0162,7164,0.127,"ALDH9A1, SRM, EHHADH, HIBCH, ALDH3A2, ALDH2, ABAT, ALDH1B1",1.79048498545737,0.896196279044043,TRUE
+"H1299","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.28374,0.881,0.546,786,1,"ELOVL2, ELOVL5, HACD1, ACOX3",0.262807357295263,0,FALSE
+"H1299","Input","KEGG_BLADDER_CANCER",-0.35677,-1.11,0.302,8433,0.463,"CCND1, THBS1, ERBB2, TP53, CDH1",0.519993057042849,0.334419008982047,FALSE
+"H1299","Input","KEGG_BUTANOATE_METABOLISM",-0.60337,-1.89,0.0231,8426,0.119,"HMGCS2, BDH2, HMGCS1, ACADS, BDH1, ALDH2, ABAT, ALDH1B1, ACSM3",1.63638802010786,0.924453038607469,TRUE
+"H1299","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31263,-0.996,0.405,7871,0.581,"GSK3B, PIK3AP1, PIK3CD, BTK, PTPN6, SYK, NFKBIA, CD81, INPP5D, RAC2",0.392544976785331,0.235823867609669,FALSE
+"H1299","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.33568,-1.03,0.366,6674,0.556,"PPP3CB, CALML3, PHKA2, GNAS, ERBB4, CAMK2D, CAMK2G, ATP2B1, ADCY9, GNA11, ATP2A3, GNAQ, SLC25A4, PRKACB, ITPKB, LTB4R2, PTK2B, P2RX4, ATP2B2, ATP2B4, ERBB2, BST1, ERBB3, MYLK, PLCB1, TNNC1, CACNA1A, TNNC2",0.436518914605589,0.254925208417942,FALSE
+"H1299","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.36738,1.18,0.241,755,0.887,"TPM2, SLC8A1, CACNA2D1, SLC9A6, CYC1, COX6C",0.617982957425132,0.0520763801682736,FALSE
+"H1299","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.53518,-1.7,0.0352,8105,0.149,"CD58, NEO1, VCAM1, CD274, ITGAV, ITGB2, PTPRM, F11R, CNTN1, SDC3, NECTIN1, CLDN3, SDC1, CLDN4, CLDN6, ALCAM, L1CAM, CD276, SDC2, CDH1, NRCAM, CD99, CADM1, CDH15, CDH3, ICAM2, CLDN7",1.45345733652187,0.826813731587726,TRUE
+"H1299","Input","KEGG_CELL_CYCLE",0.33724,1.09,0.317,3160,0.864,"TGFB1, ESPL1, TTK, CDK6, CDK1, BUB1, CCNB1, PRKDC, ANAPC4, ORC3, ANAPC5, ORC4, CDC20, DBF4, CDC45, ORC5, CDC16, YWHAZ, CCNB2, ORC1, MYC, CHEK1, CDC27, ORC2, ANAPC1, PLK1, CDK7, ANAPC7, CDC23, MAD2L2, MCM7, SMC3, ANAPC2, YWHAB, MCM2, SMC1A, MAD1L1, YWHAQ, ANAPC10, CDC25C, SMC1B, CUL1, BUB1B, MCM6, MCM4, MCM5, RB1, SMAD3, TGFB2",0.498940737782249,0.0634862575211067,FALSE
+"H1299","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.31113,-0.974,0.424,6212,0.593,"KRAS, NRAS, PIK3R3, BRAF, CCR4, GNB2, MAPK3, GNG2, RHOA, ARRB2, STAT2, GRB2, GNB1, GNB4, SOS1, STAT3, CCL13, HRAS, WASL, ADCY9, CCL15, RAC1, PARD3, GNG10, VAV2, PREX1, PRKACB, GSK3B, STAT1, GNB3, PIK3CD, ELMO1, PTK2B, GRK2, PRKCD, NFKBIA, ADCY5, PLCB1, CCL20, RAC2, ARRB1",0.372634143407267,0.226945306635737,FALSE
+"H1299","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.19833,0.636,0.91,1929,1,"TGFB1, CDK6, CBL, BAD, AKT1, MYC, MECOM, SHC1, AKT2, CRK, AKT3",0.0409586076789064,0,FALSE
+"H1299","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.36967,-1.17,0.243,7037,0.4,"IDH3G, DLAT, SUCLA2, ACO2, ACLY, PCK2, SUCLG2, MDH1, SUCLG1, PC, IDH1, IDH2",0.614393726401688,0.397940008672038,FALSE
+"H1299","Input","KEGG_COLORECTAL_CANCER",-0.20836,-0.657,0.919,7871,0.973,"GSK3B, APC, TCF7L1, PIK3CD, CCND1, LEF1, CTNNB1, TP53, RAC2",0.0366844886138887,0.0118871597316481,FALSE
+"H1299","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.43013,-1.36,0.133,7894,0.304,"F8, SERPING1, C5, PROC, CD46, FGA, FGG, TFPI, FGB, PLG, F3, PROS1, SERPINA1, CD55, SERPINF2, A2M, C4A, SERPINC1",0.876148359032914,0.517126416391246,FALSE
+"H1299","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.26869,0.85,0.592,1334,1,"LDHB, CBS, DNMT1, SDS, CDO1, GOT1, SMS",0.22767829327708,0,FALSE
+"H1299","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.21322,0.683,0.866,605,1,"TGFB1, TNFRSF1A, CD70, TNFRSF10A, OSMR",0.0624821079826534,0,FALSE
+"H1299","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.30925,-1.02,0.38,8812,0.567,"NFKBIA, IL6, TREX1, IL18, PYCARD",0.42021640338319,0.246416941107093,FALSE
+"H1299","Input","KEGG_DILATED_CARDIOMYOPATHY",0.39562,1.3,0.16,211,0.779,"TGFB1, ITGA4, TPM2, SLC8A1, ITGA3, DES, CACNA2D1",0.795880017344075,0.108462542327436,FALSE
+"H1299","Input","KEGG_DNA_REPLICATION",0.41963,1.32,0.15,3133,0.802,"PRIM1, PRIM2, POLA1, POLE, POLA2, POLE2, DNA2, RFC3, POLE3, RFC2, RFC5, RFC4, MCM7, MCM2, RNASEH2A, MCM6, MCM4, MCM5, RFC1",0.823908740944319,0.0958256317158365,FALSE
+"H1299","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.26076,0.831,0.653,6901,1,"ETS1, EGFR, NOTCH2, MAPK1, MAP2K1, ETV6, NOTCH3, NOTCH1, KRAS, MAPK3, GRB2, SOS1",0.185086818724926,0,FALSE
+"H1299","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.61305,-1.96,0.0164,8247,0.108,"GSTM3, CYP3A5, ALDH3A1, MGST3, GSTM4, GSTP1, MAOB, GSTM1, ALDH1A3, MGST1, GSTZ1, GSTT2",1.7851561519523,0.96657624451305,TRUE
+"H1299","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.33138,-1.04,0.358,8546,0.553,"CYP3A5, CES1, CES2, CDA",0.446116973356126,0.257274868695302,FALSE
+"H1299","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.54823,-1.7,0.0568,8277,0.149,"THBS4, COL2A1, ITGAV, THBS1, LAMA3, LAMA4, LAMA1, HSPG2, COL6A3, ITGA7, VTN, SDC3, ITGB4, COL5A1, LAMA5, COL1A2, LAMB1, TNC, COL1A1, COL4A1, COL3A1, AGRN, COL5A2, FN1, SDC1, SDC2, ITGB6, COL4A2",1.24565166428898,0.826813731587726,FALSE
+"H1299","Input","KEGG_ENDOCYTOSIS",-0.24244,-0.762,0.759,6194,0.894,"IQSEC1, KIT, HSPA2, ARAP1, ACAP3, IQSEC2, CHMP3, NEDD4L, FGFR3, ARRB2, EHD3, ARFGAP2, PIP5K1C, AP2S1, PRKCI, AGAP2, ERBB4, RAB11FIP5, CHMP2A, CLTCL1, SH3GL2, PIP4K2B, SH3GLB2, SMAP2, HRAS, EPS15, PARD3, STAM, AGAP1, IGF1R, CHMP4A, CHMP4B, STAMBP, RAB22A, RAB11FIP4, AP2A1, FGFR4, RAB5C, CBLB, SRC, LDLRAP1, CHMP4C, CHMP2B, GIT1, DAB2, DNAJC6, ARF6, EPN1, PARD6G, GRK2, ERBB3, PARD6B, DNM1, RAB11FIP1, ARRB1",0.11975822410452,0.0486624812040823,FALSE
+"H1299","Input","KEGG_ENDOMETRIAL_CANCER",-0.42658,-1.34,0.122,7871,0.313,"GSK3B, APC, TCF7L1, PIK3CD, CCND1, LEF1, ERBB2, CTNNB1, CTNNA1, CTNNA2, TP53, CDH1",0.913640169325252,0.504455662453552,FALSE
+"H1299","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.22248,-0.689,0.837,6283,0.955,"ADAM10, ATP6V0A1, ATP6V1G1, ATP6V0C, ATP6AP1, PLCG2, ATP6V1E1, MAPK8, TJP1, ATP6V1F, RAC1, ATP6V1C2, ATP6V0D1, SRC, GIT1, ATP6V0D2, F11R, NFKBIA, MAPK13",0.07727454200674,0.0199966284162537,FALSE
+"H1299","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.18053,-0.572,0.971,6212,0.989,"KRAS, NRAS, PIK3R3, BRAF, MAPK3, PLCG2, MAPK8, GRB2, SOS1, MAP2K7, ERBB4, CAMK2D, CAMK2G, HRAS, NCK2, STAT5A, GAB1, ABL2, RPS6KB2, CBLB, GSK3B, SRC, EREG, PIK3CD, ERBB2, ERBB3, AREG",0.0127807700919951,0.0048037084028206,FALSE
+"H1299","Input","KEGG_ETHER_LIPID_METABOLISM",-0.50311,-1.6,0.0569,8097,0.192,"PAFAH2, PLA2G12A, LPCAT2, PLA2G4A, PLPP3",1.24488773360493,0.71669877129645,FALSE
+"H1299","Input","KEGG_FATTY_ACID_METABOLISM",-0.38803,-1.21,0.225,7905,0.387,"ALDH3A2, CPT2, GCDH, ACOX1, ACAA1, ACADS, ACSL1, ALDH2, ALDH1B1, ACSL5",0.647817481888638,0.412289034981089,FALSE
+"H1299","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.43435,-1.36,0.121,8251,0.304,"PIK3CD, PLA2G12A, BTK, SYK, PRKCD, PLA2G4A, MAPK13, INPP5D, RAC2, MAP2K6",0.91721462968355,0.517126416391246,FALSE
+"H1299","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.36011,-1.14,0.249,8251,0.427,"PIK3CD, ARF6, MARCKSL1, MARCKS, DNM1, SYK, PRKCD, SCIN, PLA2G4A, PLPP3, AMPH, INPP5D, RAC2",0.603800652904264,0.369572124974976,FALSE
+"H1299","Input","KEGG_FOCAL_ADHESION",-0.30779,-0.965,0.463,8251,0.603,"PIK3CD, THBS4, COL2A1, ITGAV, ARHGAP5, MYL9, FLNB, CCND1, THBS1, LAMA3, LAMA4, ERBB2, LAMA1, ACTG1, MYLK, COL6A3, ITGA7, VTN, CTNNB1, ITGB4, COL5A1, LAMA5, COL1A2, LAMB1, TNC, COL1A1, COL4A1, COL3A1, COL5A2, FN1, ITGB6, RAC2, COL4A2",0.334419008982047,0.219682687859849,FALSE
+"H1299","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.55745,-1.74,0.0364,8870,0.14,"QDPR, ALPI, ALPP",1.43889861635094,0.853871964321762,TRUE
+"H1299","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.55361,-1.75,0.0407,6901,0.144,"PFKL, PFKM, GMPPB, ALDOA, PFKFB3, PFKFB2, GMPPA, AKR1B1, GMDS, HK1, KHK, MPI, PFKFB4, ALDOC, PMM2",1.39040559077478,0.84163750790475,TRUE
+"H1299","Input","KEGG_GALACTOSE_METABOLISM",-0.54319,-1.69,0.0522,6901,0.15,"PFKL, PFKM, GANC, AKR1B1, HK1, GLB1, PGM1, GALT, GALE, GAA, B4GALT1",1.28232949699774,0.823908740944319,FALSE
+"H1299","Input","KEGG_GAP_JUNCTION",-0.19341,-0.595,0.965,6756,1,"GRB2, GNAS, SOS1, TJP1, TUBAL3, HRAS, ADCY9, GUCY1A1, GNA11, GNAQ, PRKACB, SRC, ADCY5, GJA1, PLCB1, TUBA4A",0.0154726866562074,0,FALSE
+"H1299","Input","KEGG_GLIOMA",-0.18458,-0.575,0.971,6104,0.995,"PIK3R2, KRAS, NRAS, PIK3R3, BRAF, MAPK3, PLCG2, CALML3, GRB2, SOS1, CAMK2D, CAMK2G, HRAS, IGF1R, CDK4, PIK3CD, CCND1, TP53",0.0127807700919951,0.00217691925427455,FALSE
+"H1299","Input","KEGG_GLUTATHIONE_METABOLISM",-0.55513,-1.79,0.0248,8136,0.132,"G6PD, GPX2, GSTM3, GGT1, GPX6, GPX7, GSR, MGST3, GSTM4, GSTP1, IDH1, GSTM1, MGST1, GSTZ1, GSTT2, IDH2, GPX1",1.60554831917378,0.87942606879415,TRUE
+"H1299","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.42507,-1.33,0.149,6839,0.318,"DGKA, AGPAT2, TKFC, ALDH9A1, CEL, DGKD, DGKZ, AKR1B1, ALDH3A2, LIPG, ALDH2, MGLL, PLPP3, LIPC, LPL, AKR1A1, ALDH1B1",0.826813731587726,0.497572880015567,FALSE
+"H1299","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.27765,-0.861,0.597,6836,0.754,"PTDSS1, DGKA, MBOAT7, AGPAT2, CHKB, CDS1, GPD1L, LYPLA2, CDIPT, CDS2, CHKA, DGKD, DGKZ, LPGAT1, PEMT, GNPAT, PLA2G12A, LPCAT2, PLA2G4A, PLPP3",0.224025668870631,0.122628654130226,FALSE
+"H1299","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.38232,-1.2,0.226,6692,0.384,"PSPH, SHMT1, SHMT2, AGXT, MAOA, GCAT, PHGDH, SRR, GAMT, SARDH, CTH, GATM, CHDH, MAOB",0.645891560852599,0.415668775632469,FALSE
+"H1299","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.39076,-1.2,0.234,6901,0.384,"PFKL, PFKM, ACSS2, DLAT, ALDH9A1, BPGM, ALDOA, GALM, PGAM2, PCK2, ALDH3A2, HK1, LDHA, PGM1, ALDH3A1, ACSS1, ALDOC, ALDH2, ALDH1A3, AKR1A1, ALDH1B1",0.630784142589857,0.415668775632469,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.4068,-1.25,0.183,7049,0.356,"CHST11, B3GAT3, CHPF, CHST13, CHST12, XYLT1",0.737548910269571,0.448550002027125,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.40611,-1.28,0.172,8371,0.348,"GLCE, XYLT1, HS6ST2",0.764471553092451,0.458420756053419,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.76407,-2.35,0.00189,7570,0.092,"B4GALT3, B4GAT1, B3GNT2, ST3GAL1, B4GALT4, B4GALT1",2.72353819582676,1.03621217265444,TRUE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.33106,-1.03,0.374,7666,0.556,"IDS, IDUA, GLB1, HGSNAT, NAGLU",0.42712839779952,0.254925208417942,FALSE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.41618,-1.31,0.14,8864,0.334,"ST3GAL1",0.853871964321762,0.476253533188435,FALSE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.74034,-2.34,0.0075,7570,0.0652,"B4GALT3, B4GAT1, B3GNT3, B3GNT2, ST3GAL6, ST3GAL4, B4GALT4, B4GALT1",2.1249387366083,1.18575240426808,TRUE
+"H1299","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.19378,-0.609,0.943,7000,1,"PIGO, PIGU, PIGS, PIGQ",0.0254883072626717,0,FALSE
+"H1299","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.4821,1.57,0.0641,1618,0.587,"MTHFD1L, MTHFD2L, HYI, MTHFD2, MDH2, CS",1.19314197048118,0.231361898752386,FALSE
+"H1299","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31871,-1,0.412,6707,0.58,"CALML3, MAPK8, GRB2, GNAS, SOS1, MAP2K7, CAMK2D, CAMK2G, HRAS, ADCY9, GNA11, GNAQ, PRKACB, MAP3K1, SRC, MMP14, PTK2B, PLA2G12A, PRKCD, ADCY5, PLCB1, PLA2G4A, MAPK13, MAP2K6",0.385102783966865,0.236572006437063,FALSE
+"H1299","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.64355,-2.07,0.00183,7408,0.108,"CSNK1E, PRKACB, GSK3B, SHH, WNT16, SUFU, WNT11",2.73754891026957,0.96657624451305,TRUE
+"H1299","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.4814,1.54,0.0675,1229,0.558,"ITGA4, ITGA3, CD44, ANPEP, CD59, ITGA6, ITGA5, MME, CD9",1.17069622716898,0.253365801062421,FALSE
+"H1299","Input","KEGG_HISTIDINE_METABOLISM",-0.58082,-1.86,0.0208,7582,0.122,"MAOA, ALDH3A2, HNMT, DDC, ALDH3A1, ALDH2, MAOB, ALDH1A3, ALDH1B1",1.68193666503724,0.913640169325252,TRUE
+"H1299","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.51928,1.67,0.0346,1324,0.497,"RAD51C, RAD52, SEM1, TOP3A, BLM, RAD50, NBN, MRE11",1.46092390120722,0.303643611266668,FALSE
+"H1299","Input","KEGG_HUNTINGTONS_DISEASE",0.16839,0.535,0.98,4015,1,"PLCB4, CYC1, COX6C, NDUFA9, POLR2B, CYCS, NDUFB4, UQCRQ, TBP, NDUFS2, DLG4, POLR2K, NDUFB7, POLR2A, RCOR1, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, TGM2, TFAM, POLR2G, HIP1, DCTN1, NDUFA4, NDUFC2, ITPR1, GRM5, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, DCTN2, ATP5PO, NDUFA6, NDUFA10, COX4I1, COX6B1, POLR2E, POLR2I, ATP5PB, NDUFB10, NDUFB9, GRIN1, SDHD, COX5A, POLR2J, UQCRC2, POLR2C, SIN3A, IFT57, HDAC2, APAF1, NDUFB2, CASP9, CLTC, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB, SLC25A31, NDUFV1, ATP5F1A, HTT, DCTN4, UQCRH, VDAC2, ATP5F1C",0.00877392430750515,0,FALSE
+"H1299","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.38084,1.22,0.221,211,0.912,"TGFB1, ITGA4, TPM2, SLC8A1, ITGA3, DES, CACNA2D1",0.655607726314889,0.0400051616715838,FALSE
+"H1299","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30975,1,0.384,999,0.976,"ISYNA1, IMPA1, PLCB4, SYNJ2, SYNJ1, INPP5K, INPP4B",0.415668775632469,0.0105501823333082,FALSE
+"H1299","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.21631,-0.676,0.878,5890,0.957,"CALM2, CRKL, PPP1CB, PPP1R3D, IKBKB, PTPRF, PIK3R2, PHKG2, KRAS, NRAS, HK2, PHKB, PIK3R3, PRKAR2B, HK3, BRAF, PYGB, MAPK3, CALML3, MAPK8, PRKCI, PHKA2, GRB2, SOS1, PRKAR1A, PRKAR1B, HRAS, PYGL, EXOC7, PDPK1, FLOT1, PDE3A, PCK2, RPS6KB2, CBLB, PRKACB, GSK3B, MKNK1, FOXO1, HK1, SORBS1, FLOT2, PRKAA2, PIK3CD, INSR, IRS2, GYS1, INPP5D",0.0565054840938974,0.0190880622231565,FALSE
+"H1299","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.59836,1.87,0.0348,49,1,"TGFB1, ITGA4",1.45842075605342,0,FALSE
+"H1299","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.22286,-0.716,0.847,6637,0.923,"STAT2, LIFR, GRB2, SOS1, STAT3, IFNAR1, STAM, STAT5A, PIM1, CBLB, STAT1, CREBBP, IL13RA1, EP300, PIK3CD, CCND1, IRF9, PTPN6, STAT6, IL6",0.0721165896692931,0.0347982989740879,FALSE
+"H1299","Input","KEGG_LEISHMANIA_INFECTION",0.30283,0.956,0.432,536,1,"TGFB1, ITGA4, JUN, MAP3K7, IRAK4",0.364516253185088,0,FALSE
+"H1299","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.3717,-1.17,0.245,8232,0.4,"VCAM1, PIK3CD, ARHGAP5, MYL9, PTK2B, ITGB2, F11R, ACTG1, CTNNB1, CTNND1, CLDN3, CTNNA1, CLDN4, CTNNA2, CLDN6, MAPK13, RAC2, CD99, CLDN7",0.610833915635468,0.397940008672038,FALSE
+"H1299","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.65603,-2.04,0.00962,7164,0.104,"ALDH9A1, EHHADH, ALDH3A2, ALDH2, ALDH1B1",2.01682492796219,0.98296666070122,TRUE
+"H1299","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.79212,-2.51,0.0018,8416,0.0409,"PLA2G12A, CYP3A5, CYP2J2, PLA2G4A",2.74472749489669,1.38827669199266,TRUE
+"H1299","Input","KEGG_LONG_TERM_DEPRESSION",-0.31337,-1.01,0.396,6212,0.57,"KRAS, NRAS, BRAF, PLA2G12B, MAPK3, RYR1, GUCY1B1, GNAS, HRAS, GUCY1A1, GNA11, IGF1R, GNAQ, GNA13, PLA2G12A, GNAO1, PLCB1, CACNA1A, PLA2G4A",0.402304814074488,0.244125144327509,FALSE
+"H1299","Input","KEGG_LONG_TERM_POTENTIATION",0.15912,0.522,0.998,199,1,"ATF4, PLCB4",0.000869458712628891,0,FALSE
+"H1299","Input","KEGG_LYSINE_DEGRADATION",-0.19376,-0.593,0.968,7905,1,"ALDH3A2, GCDH, PLOD1, PLOD2, ALDH2, ALDH1B1",0.0141246426916063,0,FALSE
+"H1299","Input","KEGG_LYSOSOME",-0.39391,-1.2,0.199,7548,0.384,"LAMP1, CTSB, IDS, IDUA, GNPTAB, ATP6V0D1, PPT1, GNPTG, GGA2, SORT1, GM2A, AP1M2, AP3S2, GLB1, CTSZ, LAMP2, GBA, NAPSA, ATP6V0D2, SUMF1, ABCA2, FUCA1, ENTPD4, CTSS, SCARB2, HGSNAT, SLC11A2, ASAH1, NAGLU, GAA, ARSA, CTSH",0.701146923590293,0.415668775632469,FALSE
+"H1299","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26656,0.853,0.608,445,1,"TGFB1, FLNC, RELB, FGF13, FGF2, ATF4, TNFRSF1A, NFKB2, CACNA2D1, FGFR1, MAP2K3, JUN, MAP3K7",0.216096420727265,0,FALSE
+"H1299","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.63279,-2.01,0.0183,7212,0.0878,"HES1, HNF1B, MNX1, IAPP, NEUROD1, HNF1A, HNF4A, FOXA2",1.73754891026957,1.0565054840939,TRUE
+"H1299","Input","KEGG_MELANOGENESIS",-0.50213,-1.59,0.0626,7032,0.194,"CAMK2D, CAMK2G, HRAS, ADCY9, CREB1, ASIP, TCF7L2, GNAQ, FZD7, PRKACB, GSK3B, CREBBP, KITLG, TCF7L1, EP300, LEF1, GNAO1, DCT, WNT16, CREB3L2, CTNNB1, ADCY5, MITF, TYRP1, PLCB1, WNT11",1.20342566678957,0.712198270069774,FALSE
+"H1299","Input","KEGG_MELANOMA",0.32989,1.05,0.351,235,0.881,"FGF13, FGF2, CDK6, FGFR1",0.454692883534176,0.0550240915879521,FALSE
+"H1299","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.59808,-1.88,0.00954,8139,0.118,"CYP1B1, GSTM3, CYP3A5, ALDH3A1, MGST3, GSTM4, GSTP1, CYP2S1, EPHX1, GSTM1, ALDH1A3, MGST1, GSTZ1, GSTT2",2.0204516252959,0.928117992693875,TRUE
+"H1299","Input","KEGG_MISMATCH_REPAIR",0.25847,0.823,0.646,3817,1,"RFC3, RFC2, RFC5, PMS2, RFC4, MSH3, RFC1, MSH6, RPA2, SSBP1, MSH2",0.189767482004916,0,FALSE
+"H1299","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.15967,0.512,0.995,2192,1,"ULK1, AKT1, ULK3, RICTOR, RPS6KB1, AKT2, AKT3, RPTOR, RPS6, PRKAA1, MTOR",0.00217691925427455,0,FALSE
+"H1299","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.23437,-0.736,0.781,6099,0.907,"PPP3CA, PIK3R2, KRAS, NRAS, IFNAR2, PIK3R3, BRAF, TNFRSF10B, MAPK3, BID, PLCG2, PPP3CB, GRB2, TNFRSF10D, SOS1, IFNAR1, RAET1L, ULBP2, HRAS, RAC1, VAV2, PIK3CD, LCK, PTK2B, ITGB2, PTPN6, SYK, RAC2, ICAM2",0.1073489661227,0.0423927129399047,FALSE
+"H1299","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.23196,-0.722,0.804,6550,0.921,"F2, TSPO, PARD3, LTB4R2, PLG, P2RX4",0.0947439512515487,0.0357403698031511,FALSE
+"H1299","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.21115,-0.676,0.866,6212,0.957,"KRAS, NRAS, MAP3K3, PIK3R3, RPS6KA6, ARHGDIA, BRAF, MAPK3, RHOA, PLCG2, RPS6KA3, YWHAH, CALML3, MAPK8, BAX, GRB2, SOS1, MAP2K7, CAMK2D, CAMK2G, HRAS, MAP3K5, RAC1, RPS6KA5, PDPK1, GAB1, MAPKAPK2, RPS6KA4, MAP3K1, GSK3B, SORT1, RPS6KA2, ARHGDIB, PIK3CD, RPS6KA1, IRS2, PRKCD, NFKBIA, MAPK13, NGFR, TP53",0.0624821079826534,0.0190880622231565,FALSE
+"H1299","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.50481,-1.55,0.0794,8445,0.206,"PNP, BST1, NNMT, NNT, NUDT12, QPRT",1.1001794975729,0.686132779630847,FALSE
+"H1299","Input","KEGG_NITROGEN_METABOLISM",-0.43691,-1.35,0.118,7711,0.309,"CA2, CA5B, CA12, GLUL, CTH, CPS1, GLUD2",0.928117992693875,0.510041520575165,FALSE
+"H1299","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.28592,-0.879,0.576,8812,0.734,"NFKBIA, IL6, IL18, MAPK13, PYCARD",0.239577516576788,0.134303940083929,FALSE
+"H1299","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.4647,1.51,0.0734,1324,0.543,"PRKDC, RAD50, MRE11",1.13430394008393,0.265200170411153,FALSE
+"H1299","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.25345,-0.783,0.718,8251,0.864,"PIK3CD, CCND1, ERBB2, FHIT, RXRG, RXRA, TP53",0.1438755557577,0.0634862575211067,FALSE
+"H1299","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.28057,-0.888,0.556,7134,0.732,"NCOR2, MAML2, HES1, CTBP2, CREBBP, EP300, DTX3L, JAG1, JAG2",0.254925208417942,0.135488918941608,FALSE
+"H1299","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.21893,0.719,0.819,2833,1,"POLE, POLE2, RFC3, POLE3, RFC2, RFC5, CDK7, RFC4, ERCC2, XPA, GTF2H4, ERCC3",0.0867160982395816,0,FALSE
+"H1299","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.34236,-1.1,0.304,7512,0.472,"MAN1B1, B4GALT3, MAN1A2, ALG12, ALG13, MGAT5, B4GALT1, MGAT4A, ST6GAL1",0.517126416391246,0.326058001365912,FALSE
+"H1299","Input","KEGG_OLFACTORY_TRANSDUCTION",0.224,0.728,0.833,1062,1,"PDE1C, CNGB1",0.0793549985932124,0,FALSE
+"H1299","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.35284,1.12,0.294,2549,0.936,"MTHFD1L, MTHFD2L, MTHFD2, TYMS, GART, MTHFD1",0.531652669587843,0.0287241512618947,FALSE
+"H1299","Input","KEGG_OOCYTE_MEIOSIS",0.3392,1.11,0.294,2416,0.909,"STAG3, ESPL1, CDK1, BUB1, CCNB1, ANAPC4, PPP2R5E, PPP2R5D, PPP2R5C, ANAPC5, CDC20, PPP2R1B, SGO1, CDC16, YWHAZ, CCNB2, CDC27, CHP1, ANAPC1, PLK1, PPP1CC, ANAPC7, PPP1CA, CDC23, MAD2L2, SLK, SMC3, ANAPC2, ITPR1, PPP3CC, YWHAB",0.531652669587843,0.0414361167780325,FALSE
+"H1299","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.44465,-1.4,0.112,7614,0.287,"FUCA2, GLB1, GBA, FUCA1",0.950781977329818,0.542118103266008,FALSE
+"H1299","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22338,0.71,0.848,3800,1,"CYC1, COX15, COX6C, NDUFA9, NDUFB4, UQCRQ, NDUFS2, NDUFB7, NDUFA11, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, COX11, NDUFA4, NDUFC2, NDUFS3, UQCRFS1, ATP6V0A2, NDUFA5, NDUFA2, ATP6V1D, ATP5PO, ATP6V1C1, NDUFA6, NDUFA10, COX4I1, COX6B1, ATP5PB, NDUFB10, NDUFB9, SDHD, COX5A, ATP5MG, UQCRC2, NDUFB2, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB",0.0716041477432862,0,FALSE
+"H1299","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.71766,-2.28,0,7307,0.0467,"GALNT14, GALNT15, GALNT13, GALNT7, B3GNT6, GALNT1, GALNT6, B4GALT5, GALNT2, GALNT5, ST3GAL1, GALNT3, GALNT12",Inf,1.33068311943389,TRUE
+"H1299","Input","KEGG_P53_SIGNALING_PATHWAY",0.24681,0.799,0.674,1843,1,"SERPINE1, STEAP3, CDK6, CDK1, CCNB1, CD82, CYCS, CCNB2, CHEK1, RRM2B, RRM2, GTSE1",0.17134010346468,0,FALSE
+"H1299","Input","KEGG_PANCREATIC_CANCER",-0.19446,-0.61,0.935,7916,1,"CDK4, STAT1, ARHGEF6, PIK3CD, CCND1, ERBB2, TP53, RAC2",0.0291883891274822,0,FALSE
+"H1299","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41145,-1.29,0.155,6012,0.343,"COASY, PPCS, PANK3, PANK2, BCAT2, ENPP1, PANK1",0.809668301829709,0.464705879957229,FALSE
+"H1299","Input","KEGG_PARKINSONS_DISEASE",0.27221,0.844,0.6,4015,1,"UCHL1, CYC1, COX6C, HTRA2, NDUFA9, CYCS, NDUFB4, UQCRQ, NDUFS2, UBE2G1, NDUFB7, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, NDUFA4, NDUFC2, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, ATP5PO, NDUFA6, NDUFA10, COX4I1, UBE2J2, COX6B1, ATP5PB, NDUFB10, NDUFB9, SDHD, COX5A, UQCRC2, APAF1, NDUFB2, CASP9, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB, SLC25A31, NDUFV1, ATP5F1A, UQCRH, VDAC2, ATP5F1C",0.221848749616356,0,FALSE
+"H1299","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.2403,-0.76,0.76,8587,0.89,"ACTG1, CTNNB1, TUBA4A, CDH1",0.119186407719209,0.0506099933550872,FALSE
+"H1299","Input","KEGG_PATHWAYS_IN_CANCER",-0.28055,-0.883,0.568,7701,0.735,"LAMB3, LAMC1, CBLB, FZD7, ARNT, EGLN1, GSK3B, CDK4, STAT1, FOXO1, CREBBP, APC, KITLG, TCF7L1, TRAF5, SHH, EP300, PIK3CD, SKP2, ITGAV, CCND1, LAMA3, LAMA4, NCOA4, LEF1, ERBB2, LAMA1, PTGS2, WNT16, AR, CTNNB1, NFKBIA, LAMA5, SUFU, MITF, GSTP1, CEBPA, IL6, LAMB1, COL4A1, CTNNA1, RXRG, TRAF4, FN1, CTNNA2, RXRA, TP53, RAC2, COL4A2, CDH1, WNT11",0.245651664288981,0.133712660915805,FALSE
+"H1299","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.63939,-2.03,0.00591,5961,0.0914,"UGP2, GUSB, RPE, XYLB, UGDH, AKR1B1, CRYL1, DCXR",2.22841251911874,1.03905380426617,TRUE
+"H1299","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.49597,-1.57,0.0618,6410,0.203,"PRPS1, PRPS1L1, DERA, PFKL, PFKM, ALDOA, H6PD, PGD, G6PD, TALDO1, TKT, PGM1, ALDOC",1.20901152491118,0.692503962086787,FALSE
+"H1299","Input","KEGG_PEROXISOME",-0.44561,-1.4,0.121,7248,0.287,"GSTK1, AGXT, EHHADH, MVK, SCP2, PEX13, HSD17B4, GNPAT, DECR2, AMACR, PHYH, ABCD3, PECR, ACOX1, ACAA1, ACSL1, DHRS4, IDH1, NUDT12, EPHX2, ACSL5, IDH2",0.91721462968355,0.542118103266008,FALSE
+"H1299","Input","KEGG_PHENYLALANINE_METABOLISM",-0.60771,-1.92,0.0183,6665,0.108,"ALDH3B1, PRDX6, PAH, MIF, MAOA, DDC, ALDH3A1, MAOB, ALDH1A3",1.73754891026957,0.96657624451305,TRUE
+"H1299","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.21024,0.681,0.879,999,1,"DGKE, IMPA1, PLCB4, SYNJ2, SYNJ1, INPP5K, INPP4B",0.0560111249262281,0,FALSE
+"H1299","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.32269,-1.01,0.389,7998,0.57,"HMBS, FTH1, UROS, CP",0.410050398674292,0.244125144327509,FALSE
+"H1299","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.50039,-1.56,0.0699,7013,0.205,"SLC27A1, RXRB, ACOX2, APOA1, EHHADH, PDPK1, PCK2, SCP2, CPT2, SORBS1, OLR1, HMGCS2, CYP27A1, FABP7, ACOX1, ACAA1, ACSL1, FABP3, ME1, RXRG, APOA2, LPL, RXRA, ACSL5, FABP1, FADS2",1.15552282425432,0.688246138944246,FALSE
+"H1299","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.72431,-2.25,0.00345,7780,0.0431,"SCP2, HSD17B4, AMACR, CYP27A1, CYP7B1, HSD3B7",2.46218090492673,1.36552272983927,TRUE
+"H1299","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.37526,-1.17,0.261,8065,0.4,"ADA, LCK, BTK",0.583359492661719,0.397940008672038,FALSE
+"H1299","Input","KEGG_PRION_DISEASES",-0.39415,-1.26,0.165,5965,0.361,"NOTCH1, SOD1, MAPK3, BAX, HSPA5, C9, NCAM1, LAMC1, PRKACB, C5, IL6",0.782516055786094,0.442492798094342,FALSE
+"H1299","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.23397,0.746,0.776,2064,1,"HSP90AA1, CDK1, BUB1, CCNB1, ANAPC4, ANAPC5, AKT1, HSP90AB1, CDC16, CCNB2, CDC27, ANAPC1, PLK1, AKT2, AKT3, ANAPC7, CDC23, MAD2L2",0.110138278741812,0,FALSE
+"H1299","Input","KEGG_PROPANOATE_METABOLISM",-0.61286,-1.94,0.0177,7127,0.105,"ACSS2, ALDH9A1, SUCLA2, EHHADH, SUCLG2, SUCLG1, HIBCH, ALDH3A2, LDHA, PCCA, ACSS3, ALDH6A1, ACSS1, PCCB, ALDH2, ABAT, ALDH1B1, MCEE",1.75202673363819,0.978810700930062,TRUE
+"H1299","Input","KEGG_PROSTATE_CANCER",-0.30791,-0.982,0.45,6891,0.592,"HSP90B1, SOS1, CREB5, HRAS, CREB1, PDPK1, IGF1R, TCF7L2, GSK3B, FOXO1, CREBBP, TCF7L1, EP300, PIK3CD, CCND1, LEF1, ERBB2, AR, CREB3L2, CTNNB1, NFKBIA, GSTP1, TP53",0.346787486224656,0.22767829327708,FALSE
+"H1299","Input","KEGG_PROTEASOME",0.21338,0.689,0.872,4175,1,"SEM1, PSMC1, POMP, PSMB5, PSMC2, PSMD4, PSMD6, PSME4, PSMB4, PSMB7, PSMD1, PSMB6, PSMB2, PSMD13, PSMD8, PSMD11, PSMC5, PSMA8, PSMF1, PSMD12, PSMD3, PSMD14, PSMA4, PSMB1, PSMD7, PSMD2, PSMC6, PSMC4, PSMA1, PSMA2, PSMA3",0.0594835150674328,0,FALSE
+"H1299","Input","KEGG_PROTEIN_EXPORT",0.22507,0.717,0.822,2880,1,"SEC63, SRPRA, OXA1L, SRPRB, SRP14, IMMP2L",0.0851281824599496,0,FALSE
+"H1299","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.65934,-2.05,0.00543,7168,0.109,"ATP1A3, ATP1A1, SLC25A10, PCK2, ATP1B3, CA2, MDH1, ATP1A4, AQP1, ATP1B1, GLUD2",2.26520017041115,0.962573502059376,TRUE
+"H1299","Input","KEGG_PURINE_METABOLISM",0.15772,0.498,0.996,2599,0.995,"NT5E, PRIM1, NME6, POLR1E, PRIM2, POLA1, POLE, ADCY10, POLA2, POLE2, PDE1C, POLR2B, NME1, HPRT1, POLE3, POLR2K, RRM2B, POLR2A, PDE6D, RRM2, NT5C3A, GART, POLR2G, NUDT2, PFAS, PNPT1, DGUOK, NME2, GMPS, NT5C2, PDE6C, GMPR2",0.00174066157630127,0.00217691925427455,FALSE
+"H1299","Input","KEGG_PYRIMIDINE_METABOLISM",0.27474,0.869,0.622,1879,1,"NT5E, PRIM1, NME6, POLR1E, DHODH, PRIM2, POLA1, POLE, POLA2, POLE2, POLR2B, NME1, UMPS, UCKL1, TXNRD2, POLE3, DUT, POLR2K, RRM2B, POLR2A, TYMS, RRM2, NT5C3A",0.206209615309181,0,FALSE
+"H1299","Input","KEGG_PYRUVATE_METABOLISM",-0.39668,-1.25,0.183,7127,0.356,"ACSS2, DLAT, ALDH9A1, PCK2, MDH1, AKR1B1, ALDH3A2, PC, LDHA, HAGH, ACSS1, ME1, ALDH2, ALDH1B1",0.737548910269571,0.448550002027125,FALSE
+"H1299","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.18943,-0.585,0.949,7119,0.997,"PIP4K2B, ITGB3, PIP4K2A, HRAS, WASL, RAC1, ITGA2B, CFL1, VAV2, ITGA1, CYFIP2, ITGB8, FGFR4, GNA13, BRK1, WASF2, ARHGAP35, IQGAP2, ARHGEF6, APC, FGD1, GIT1, PIK3CD, ITGAV, MYL9, ITGB2, ACTG1, BAIAP2, MYLK, ITGA7, MYH14, ITGB4, SCIN, ENAH, FN1, DIAPH2, ITGB6, RAC2",0.0227337875727074,0.00130484168834428,FALSE
+"H1299","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.54176,1.72,0.0351,2579,0.702,"GABARAPL2, ULK1, ATG7, GABARAPL1, ATG5, PIK3R4, ULK3, ATG12, PRKAA1, ATG4B, PIK3C3, ATG3",1.45469288353418,0.153662887870195,FALSE
+"H1299","Input","KEGG_RENAL_CELL_CARCINOMA",0.25385,0.827,0.666,1929,1,"TGFB1, PAK4, JUN, RAP1B, ETS1, AKT1, FH, AKT2, FLCN, CRK, AKT3",0.176525770829699,0,FALSE
+"H1299","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.41002,1.33,0.142,3212,0.861,"ANPEP, MME, MAS1, THOP1, CTSA, ACE, LNPEP",0.847711655616944,0.0649968485463452,FALSE
+"H1299","Input","KEGG_RETINOL_METABOLISM",-0.47988,-1.5,0.083,8546,0.233,"CYP3A5, PNPLA4, DHRS4, ALDH1A1, ALDH1A2",1.08092190762393,0.632644078973981,FALSE
+"H1299","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.45108,-1.41,0.114,7317,0.288,"ACP5, FLAD1, ENPP1, ACP6",0.943095148663527,0.540607512240769,FALSE
+"H1299","Input","KEGG_RIBOSOME",0.5487,1.75,0.0306,3176,0.938,"RPL22, RPL26L1, RPL7, RPL8, RPL6, RPS23, RPL14, RPL28, RPL29, RPL19, RPL7A, RPS8, RPL36, RPS11, RPL37A, FAU, RPL26, RPL17, RPL23A, RPL34, RPL15, RPL36A, RPL36AL, RPL35A, RPS3A, RPL18, RPL21, RPL10A, RPL32, RPL13A, RPL4, RPL38, RPS6, RPS18, RPL27A, RPS13, RPL31, RPL23, RPS9, RPS29, RPS5, UBA52, RPS24, RPL30, RPL9, RPL37, RPS4X, RPS12, RPS15, RPS19, RPS25, RPL24, RSL24D1, MRPL13, RPL13, RPS17, RPL18A, RPL5, RPL3, RPL27, RPL35, RPL10, RPS2, RPS15A",1.51427857351842,0.0277971616209356,FALSE
+"H1299","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.25725,-0.8,0.693,7646,0.857,"ISG15, MAP3K1, SIKE1, MAVS, CYLD, NFKBIA, DDX3Y, MAPK13, CASP10",0.159266765388193,0.0670191780768018,FALSE
+"H1299","Input","KEGG_RNA_DEGRADATION",0.22372,0.721,0.832,3281,1,"MTREX, EXOSC10, EXOSC5, EXOSC7, EXOSC9, EXOSC3, XRN1, EXOSC8, EXOSC1, PNPT1, EXOSC6, LSM1, CNOT4, CNOT6L, EXOSC2, LSM2, HSPD1, HSPA9, PAPOLA, PATL1, CNOT2",0.0798766737092761,0,FALSE
+"H1299","Input","KEGG_RNA_POLYMERASE",0.19896,0.617,0.924,3472,1,"POLR1E, POLR2B, POLR2K, POLR2A, POLR2G, POLR2E, POLR2I, POLR2J, POLR3G, POLR2C",0.0343280287798933,0,FALSE
+"H1299","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.31116,-0.978,0.416,6936,0.592,"PAPSS1, GGT7, SEPHS1, AHCYL1, SCLY, MAT1A, GGT1, CTH",0.380906669373257,0.22767829327708,FALSE
+"H1299","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.39391,-1.23,0.198,8251,0.374,"PIK3CD, SKP2, ITGAV, CCND1, LAMA3, LAMA4, LAMA1, PTGS2, NFKBIA, LAMA5, FHIT, LAMB1, COL4A1, RXRG, TRAF4, FN1, RXRA, TP53, COL4A2",0.703334809738469,0.42712839779952,FALSE
+"H1299","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.1493,-0.467,0.996,9227,0.997,"VAMP8",0.00174066157630127,0.00130484168834428,FALSE
+"H1299","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33909,1.1,0.31,970,0.885,"UGCG, UGT8, SMPD2, SGPP1, GALC, KDSR, PLPP2",0.508638306165727,0.0530567293021746,FALSE
+"H1299","Input","KEGG_SPLICEOSOME",0.53244,1.7,0.0507,3386,0.561,"DHX16, ALYREF, DHX38, BUD31, PRPF8, HNRNPA1, SNRPA, CDC5L, DDX23, PRPF6, RBM25, EFTUD2, SNRNP200, PRPF3, SNRPD3, CDC40, USP39, CTNNBL1, HNRNPU, SRSF9, PRPF31, PLRG1, AQR, SNRPE, MAGOHB, WBP11, SF3B4, BCAS2, NCBP1, SNRNP40, TXNL4A, U2AF2, SART1, RBM22, SF3B1, PPIL1, DDX39B, PUF60, HSPA1A, SNW1, DDX5, SNRPB, PRPF38A, RBMX, SYF2, XAB2, PQBP1, EIF4A3, CHERP, U2AF1, SLU7, HSPA8, SRSF6, TCERG1, NCBP2, TRA2B, TRA2A, SNRPB2, PRPF19, SNRPD1, SNRPD2, PRPF40A, SRSF5, HNRNPC, SNRPC, SNU13, SF3A3, SNRPG, SNRPA1, LSM2, SF3B6, HSPA6, SNRPF, SF3A1, PHF5A, SRSF1, PRPF4, CWC15, HNRNPM, SRSF4, U2SURP, DDX46, SF3A2, SMNDC1, CRNKL1",1.29499204066666,0.251037138743839,FALSE
+"H1299","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.55258,-1.77,0.0251,5917,0.138,"SI, GBE1, UGP2, AGL, GUSB, HK2, HK3, PYGB, PGM2L1, GANC, PYGL, UGDH, ENPP1, HK1, PGM1, UXS1, GYS1, GAA",1.60032627851896,0.860120913598763,TRUE
+"H1299","Input","KEGG_STEROID_BIOSYNTHESIS",-0.62292,-1.95,0.013,6846,0.107,"LSS, CEL, LIPA, FDFT1, EBP, HSD17B7, DHCR7, SC5D, DHCR24, SQLE, MSMO1",1.88605664769316,0.97061622231479,TRUE
+"H1299","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.7242,-2.26,0,7022,0.0458,"HSD17B8, AKR1C3, HSD17B12, AKR1C1, AKR1C2, HSD17B7, CYP1B1, CYP7B1, CYP3A5, HSD17B2, HSD3B1, STS, HSD11B2, CYP21A2",Inf,1.33913452199613,TRUE
+"H1299","Input","KEGG_SULFUR_METABOLISM",-0.57833,-1.82,0.0302,6936,0.122,"PAPSS1, CHST11, BPNT1, CHST13, CHST12, SULT1A1, SULT1A3",1.51999305704285,0.913640169325252,TRUE
+"H1299","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.22562,0.733,0.812,2791,1,"ELANE, CD40, SNRPD3, SNRPB, ACTN4, ACTN1, SNRPD1, C2",0.0904439707588247,0,FALSE
+"H1299","Input","KEGG_TASTE_TRANSDUCTION",-0.58189,-1.82,0.0267,6807,0.122,"GNAS, GNB1, PRKACB, GNB3, CACNA1A",1.57348873863542,0.913640169325252,TRUE
+"H1299","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.47691,-1.49,0.0897,7560,0.236,"MVK, HMGCR, HMGCS2, GGPS1, HMGCS1",1.04720755695591,0.627087997029893,FALSE
+"H1299","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.23701,0.76,0.774,1541,1,"TGFB1, SMURF1, SMURF2, THBS3, ZFYVE9, PPP2R1B, ACVR1, MYC",0.111259039317107,0,FALSE
+"H1299","Input","KEGG_THYROID_CANCER",-0.59161,-1.85,0.0299,7024,0.122,"RXRB, PAX8, HRAS, CCDC6, TCF7L2, TCF7L1, CCND1, NCOA4, LEF1, CTNNB1, RXRG, RXRA, TP53, CDH1",1.52432881167557,0.913640169325252,TRUE
+"H1299","Input","KEGG_TIGHT_JUNCTION",-0.47267,-1.48,0.0781,7888,0.234,"SRC, CDK4, TJP3, AMOTL1, MAP3K20, EXOC4, PPP2R2A, PATJ, MYL9, PRKCH, PARD6G, F11R, ACTG1, PPP2R2B, PARD6B, TJP2, MYH14, MYH7B, PRKCD, CTNNB1, SPTAN1, EPB41, LLGL2, EPB41L3, CLDN3, CTNNA1, CLDN4, CTNNA2, CLDN6, PRKCQ, EPB41L1, CLDN7, CRB3",1.1073489661227,0.630784142589857,FALSE
+"H1299","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.24179,-0.757,0.774,8511,0.887,"TOLLIP, NFKBIA, IL6, MAPK13, MAP2K6, MYD88",0.111259039317107,0.0520763801682736,FALSE
+"H1299","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.528,-1.65,0.0429,7164,0.17,"ALDH9A1, KYNU, EHHADH, MAOA, ALDH3A2, GCDH, CYP1B1, DDC, ALDH2, MAOB, ALDH1B1",1.36754270781528,0.769551078621726,TRUE
+"H1299","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.43264,-1.36,0.134,5981,0.304,"IKBKB, PIK3R2, HK2, PIK3R3, HK3, MAPK3, PDX1, MAPK8, ABCC8, HK1, PIK3CD, INSR, IRS2, PRKCD, CACNA1A",0.872895201635192,0.517126416391246,FALSE
+"H1299","Input","KEGG_TYROSINE_METABOLISM",-0.46463,-1.48,0.0829,8463,0.234,"DDC, DCT, HGD, ALDH3A1, TYRP1, MAOB, ALDH1A3, GSTZ1",1.08144546944973,0.630784142589857,FALSE
+"H1299","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.1836,-0.567,0.966,7371,0.983,"NCK2, PDPK1, VAV2, CBLB, GSK3B, CDK4, DLG1, PIK3CD, LCK, PTPN6, NFKBIA, MAPK13, PRKCQ",0.0150228735845067,0.00744648216786438,FALSE
+"H1299","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29335,0.921,0.482,1847,1,"FBXO2, UBE2W, SMURF1, FBXW7, TRIP12, UBE4B, CDC34, NEDD4, CUL7, ANAPC4, BIRC2, SMURF2, CBL, HERC4, ANAPC5, UBE2B, BIRC6, UBE2K, CDC20, FANCL, CDC16, UBE2G1, CDC27, TRAF6, FBXO4, ANAPC1, CUL3, HERC2",0.31695296176115,0,FALSE
+"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3668,1.19,0.215,3335,0.926,"BCAT1, VARS2, PDHA1",0.667561540084395,0.0333890133180656,FALSE
+"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.54959,-1.74,0.0387,7850,0.14,"DBT, HIBCH, ALDH3A2, AUH, PCCA, HMGCS2, ALDH6A1, ACAA1, HMGCS1, ACADS, PCCB, ALDH2, ABAT, ALDH1B1, HIBADH, MCEE",1.41228903498109,0.853871964321762,TRUE
+"H1299","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.3999,-1.25,0.193,7247,0.356,"ADCY9, GUCY1A1, MYH11, GNA11, MYL6B, GNAQ, GNA13, MYL6, ARHGEF11, PRKACB, MYL9, PLA2G12A, PRKCH, MYLK, PRKCD, ADCY5, PLCB1, PLA2G4A, PRKCQ",0.714442690992226,0.448550002027125,FALSE
+"H1299","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.23715,-0.746,0.761,6807,0.898,"GNAS, AVP, DCTN6, CREB5, ADCY9, CREB1, RAB5C, PRKACB, DYNLL2, ARHGDIB, CREB3L2",0.118615343229427,0.0467236633326956,FALSE
+"H1299","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.247,-0.786,0.726,8251,0.875,"PIK3CD, PLA2G12A, PTGS2, PLA2G4A, MAPK13, RAC2",0.139063379299906,0.0579919469776868,FALSE
+"H1299","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.44029,-1.36,0.135,6334,0.304,"ATP6V0A1, ATP6V1G1, ATP6V0C, ATP6AP1, PLCG2, ATP6V1E1, GNAS, TJP1, ATP6V1F, ADCY9, ATP6V1C2, KDELR3, SLC12A2, PRKACB, ATP6V0D1, ATP6V0D2, PDIA4, ACTG1, TJP2, KDELR1",0.869666231504994,0.517126416391246,FALSE
+"H1299","Input","KEGG_VIRAL_MYOCARDITIS",-0.37315,-1.17,0.244,8387,0.4,"ITGB2, CCND1, ACTG1, CD55, MYH14, MYH7B, SGCD, RAC2",0.612610173661271,0.397940008672038,FALSE
+"H1299","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.29815,-0.942,0.484,7299,0.638,"RAC1, CTBP2, CSNK1E, TBL1XR1, TCF7L2, SFRP1, FZD7, PRKACB, DKK1, GSK3B, CREBBP, APC, TCF7L1, TBL1X, EP300, PPP2R5A, CCND1, LEF1, DAAM2, NKD2, WNT16, CTNNB1, PLCB1, DAAM1, TP53, RAC2, WNT11",0.315154638355588,0.195179321278838,FALSE
+"H1703","Input","KEGG_ABC_TRANSPORTERS",-0.4043,-1.2,0.221,7682,0.586,"ABCD4, ABCD3, ABCC3, ABCG2, ABCA2, ABCB6, ABCA1",0.655607726314889,0.232102383981909,FALSE
+"H1703","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.27251,-0.801,0.733,6970,0.933,"PML, MYC, PIK3CA, TCF7L2, PIM1, PIK3CB, HRAS, PIK3R1, PIK3R2, PIK3CD, CCND1, RUNX1",0.134896025358872,0.0301183562535,FALSE
+"H1703","Input","KEGG_ADHERENS_JUNCTION",-0.28153,-0.826,0.677,7033,0.926,"PTPN6, RAC3, MET, TCF7L2, BAIAP2, CTNNA2, TGFBR1, CTNNA1, PTPRF, PTPN1, SNAI2, CTNNB1, ACTN4, CTNND1, IGF1R, RAC2, WAS",0.169411331314856,0.0333890133180656,FALSE
+"H1703","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.23757,0.749,0.782,2487,0.957,"STAT3, ACACB, NFKBIE, MAPK9, TNFRSF1A, MAPK10, IKBKG, CPT1A, NFKBIB, CPT1C, RELA, PRKAB2, MAPK8, CAMKK2, TRAF2, AKT1, TRADD, STK11, PRKAB1, NFKB1, PRKAG2",0.106793246940152,0.0190880622231565,FALSE
+"H1703","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.36686,1.1,0.307,1463,0.894,"GLUL, ASNS, GLUD2, NIT2, ADSL, ASL, CAD, GOT1",0.512861624522813,0.0486624812040823,FALSE
+"H1703","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.50319,-1.47,0.0954,6972,0.418,"HSD11B2, PIK3CA, IRS2, PIK3CB, PDPK1, SFN, ATP1A2, PIK3R1, IRS1, PIK3R2, SLC9A3R2, PIK3CD",1.0204516252959,0.378823718224965,FALSE
+"H1703","Input","KEGG_ALZHEIMERS_DISEASE",0.28813,0.892,0.542,3141,0.994,"GRIN1, ATP2A3, GAPDH, COX6A1, PSEN2, COX6C, TNFRSF1A, PLCB2, NDUFA4, CASP7, CAPN1, COX7C, ITPR2, PLCB3, NDUFA8, COX7A2, CASP9, SDHA, MAPT, SDHB, BID, ATP5F1B, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, IDE, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, ATP5PD, UQCRQ, UQCRC1, CASP3, NDUFA7, CDK5, UQCRH, CALML3, NDUFC1, BAD, NDUFB5, NDUFS5, CYCS, NDUFA2, SDHD, CALM2, BACE2, NDUFB1, GNAQ, NDUFC2, CASP8, COX5A, NDUFB10, NDUFS7, PSEN1, UQCRC2, ATP5PB, NDUFS8, NDUFV3",0.266000713461613,0.00261361560268669,FALSE
+"H1703","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.22961,-0.671,0.894,7187,0.99,"NARS2, EARS2, PARS2, CARS2, MARS2",0.0486624812040823,0.00436480540245009,FALSE
+"H1703","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.23201,0.724,0.849,2568,0.971,"AMDHD2, UAP1, NANS, PGM1, FPGT, PMM1, GALK1, GNPDA2, HEXB, GNPDA1, GPI, CMAS, GNE, PGM3",0.0710923097560473,0.0127807700919951,FALSE
+"H1703","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.24648,-0.729,0.797,9109,0.941,"GPX1, CASP1, TOMM40L",0.0985416786038876,0.0264103765727431,FALSE
+"H1703","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.4093,1.24,0.201,1493,0.787,"TAPBP, TAP1, CTSL, HSPA4, RFXAP, B2M, TAP2, RFXANK, IFI30, RFX5, HSP90AB1",0.696803942579511,0.104025267640935,FALSE
+"H1703","Input","KEGG_APOPTOSIS",0.23804,0.748,0.788,1398,0.942,"DFFA, RIPK1, PRKAR2B, TNFRSF1A, IL1A, ATM, XIAP, AIFM1, CASP7, IKBKG, CAPN1, MYD88, DFFB, CASP9, RELA, BID",0.103473782510445,0.0259490972071227,FALSE
+"H1703","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.68528,-2.03,0.00503,8675,0.123,"GGT5, PTGES, EPHX2, GPX6, GPX7, GPX1, PTGS2",2.29843201494407,0.910094888560602,TRUE
+"H1703","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.40013,-1.18,0.24,7871,0.57,"ALDH18A1, CKMT1A, SAT1, P4HA1, CKMT2, GLS, GLS2, P4HA2, ASS1, PRODH, PRODH2, CPS1, MAOA, AGMAT, ARG2, ARG1, LAP3",0.619788758288394,0.244125144327509,FALSE
+"H1703","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.61267,-1.85,0.0235,7584,0.211,"CTNNA2, ITGA11, DSG2, ITGA6, CTNNA1, ATP2A2, ITGA1, ITGA4, DSC2, ITGB6, ITGB4, ITGA7, CTNNB1, ACTN4, ITGB3, SLC8A1, GJA1, ITGA2, ITGB8",1.62893213772826,0.675717544702307,TRUE
+"H1703","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.52978,1.68,0.0366,110,0.526,"ALDH3A2",1.43651891460559,0.279014255846261,FALSE
+"H1703","Input","KEGG_AXON_GUIDANCE",-0.3431,-1.04,0.369,6981,0.645,"RGS3, PTK2, RAC3, GNAI3, PPP3R1, EPHA6, MET, PAK4, ARHGEF12, PPP3CA, EFNA1, PPP3CC, DPYSL5, GNAI1, HRAS, EPHA1, NRP1, EPHA4, SEMA4G, NTN4, PLXNA2, EPHA7, EFNB2, ABLIM1, ABLIM3, EPHB2, SEMA7A, RAC2, NFATC4, CXCR4",0.43297363384094,0.190440285364732,FALSE
+"H1703","Input","KEGG_BASAL_CELL_CARCINOMA",0.32135,0.988,0.404,870,0.93,"GLI3, DVL2, FZD2",0.393618634889395,0.0315170514460649,FALSE
+"H1703","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.19091,-0.566,0.972,6148,1,"TAF4, TAF5L, GTF2E1, TAF5, GTF2A1, TAF1, GTF2H4, GTF2I, GTF2H2, GTF2H3, GTF2H1",0.0123337350737254,0,FALSE
+"H1703","Input","KEGG_BASE_EXCISION_REPAIR",0.26895,0.809,0.711,2966,0.937,"MUTYH, PARP4, POLD4, HMGB1, NEIL2, PCNA, APEX1, POLL, POLE, POLD2, NTHL1",0.148130399270234,0.0282604091122217,FALSE
+"H1703","Input","KEGG_BETA_ALANINE_METABOLISM",0.33325,1.02,0.387,993,0.937,"ALDH3A2, SMS",0.412289034981089,0.0282604091122217,FALSE
+"H1703","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.30453,-0.909,0.533,7063,0.811,"ACOT2, ACOX3, ACOX1, TECR, HSD17B12, FADS2, ELOVL6",0.273272790973428,0.090979145788844,FALSE
+"H1703","Input","KEGG_BLADDER_CANCER",-0.47013,-1.41,0.0987,7425,0.475,"DAPK1, CDK4, VEGFC, HRAS, TYMP, THBS1, VEGFA, MMP2, CCND1, CDKN1A",1.00568284733036,0.323306390375133,FALSE
+"H1703","Input","KEGG_BUTANOATE_METABOLISM",-0.43968,-1.31,0.151,7866,0.558,"HMGCS1, BDH2, ABAT, ACSM3, BDH1, HMGCS2, ACADS",0.821023052706831,0.253365801062421,FALSE
+"H1703","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.35552,-1.07,0.333,7033,0.664,"PTPN6, RAC3, PPP3R1, PIK3CA, LYN, PPP3CA, PPP3CC, PIK3CB, VAV3, HRAS, PIK3R1, SYK, PIK3R2, PIK3AP1, CD81, PIK3CD, INPP5D, RAC2, NFATC4",0.47755576649368,0.177831920631982,FALSE
+"H1703","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2345,0.709,0.837,1722,0.98,"PDGFRA, GRIN1, ATP2A3, RYR1, PLCB2, ITPR2, PLCB3, PLCG2, PLCD1, TACR1, NOS3, PHKA1, PHKB, PRKACA, PRKCA, PPID",0.07727454200674,0.00877392430750515,FALSE
+"H1703","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.3647,1.09,0.303,2335,0.848,"CACNA2D1, TPM2, COX6A1, COX6C, COX7C, TPM3, COX7A2, TPM1, UQCRB, COX5B, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, UQCRQ, UQCRC1, UQCRH",0.518557371497695,0.0716041477432862,FALSE
+"H1703","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.4641,-1.37,0.135,7987,0.526,"PTPRC, PTPRF, CNTN1, ITGA4, NRCAM, ICAM1, CLDN7, ICAM2, SDC1, PDCD1LG2, CLDN3, SDC2, CADM1, SDC4, NCAM1, VCAN, CD274, PECAM1, F11R, ITGB8",0.869666231504994,0.279014255846261,FALSE
+"H1703","Input","KEGG_CELL_CYCLE",-0.14348,-0.419,1,7005,1,"TP53, BUB1B, ORC6, MYC, CCND3, CDK7, CCNB2, SKP2, CDK4, TGFB3, CDC7, SFN, BUB1, RBL1, WEE1, CDC6, TGFB2, CCND1, CDKN1A",0,0,FALSE
+"H1703","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.3855,-1.15,0.236,7014,0.589,"CCL13, RAP1B, PTK2, GNAI3, CCL20, PLCB4, PIK3CA, GNG5, CXCL6, JAK3, ARRB1, GNB1, LYN, PRKCD, RAP1A, GNB3, PIK3CB, GNAI1, STAT2, VAV3, HRAS, ADCY9, PIK3R1, GNG2, PIK3R2, PTK2B, PIK3CD, RAC2, CXCR4, WAS, CXCL1",0.627087997029893,0.229884705212898,FALSE
+"H1703","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.35831,-1.06,0.372,7539,0.638,"CDK4, PIK3CB, TGFB3, TGFBR1, BCL2L1, HRAS, PIK3R1, CBLB, PIK3R2, PIK3CD, MECOM, TGFB2, GAB2, CCND1, RUNX1, CDKN1A",0.429457060118102,0.195179321278838,FALSE
+"H1703","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.35652,-1.04,0.364,6420,0.645,"CSNK1D, CLOCK, BHLHE41, BHLHE40, CSNK1E",0.438898616350944,0.190440285364732,FALSE
+"H1703","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.13956,-0.404,1,1286,1,"ACO2, SDHA, SDHB, MDH1, ACLY, DLD, SDHD, FH, PCK2, PDHB, IDH3A, PDHA1, ACO1, SDHC, IDH3G, SUCLG2, SUCLG1, OGDH, OGDHL, MDH2, IDH1, DLAT, SUCLA2, IDH3B, IDH2, DLST, CS, PC, PCK1",0,0,FALSE
+"H1703","Input","KEGG_COLORECTAL_CANCER",-0.25572,-0.766,0.772,7005,0.916,"TP53, RAC3, MYC, PIK3CA, TCF7L2, PIK3CB, TGFB3, TGFBR1, APC, PIK3R1, CTNNB1, PIK3R2, PIK3CD, TGFB2, RAC2, CCND1",0.112382699664264,0.0381045263321496,FALSE
+"H1703","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.37835,-1.11,0.304,7762,0.607,"PROC, PLAT, C9, F5, PLAUR, C3, THBD, PLAU, SERPINA1, CD59, SERPINC1, CD55, MBL2",0.517126416391246,0.216811308924742,FALSE
+"H1703","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.27725,0.864,0.588,1617,0.994,"LDHB, MTAP, CDO1, SMS, MPST, GOT1, MAT2B, AHCY",0.230622673923862,0.00261361560268669,FALSE
+"H1703","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.32933,-0.971,0.445,8580,0.722,"EPO, IL6, VEGFA, IL1RAP, ACVR1B, TGFB2, TNFRSF12A, IL1R1, CXCR4, CXCL1, LTBR",0.351639989019068,0.141462802430361,FALSE
+"H1703","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.33329,-0.974,0.467,7330,0.726,"ADAR, POLR3D, POLR3H, POLR3A, POLR3K, POLR3B, IL6, PYCARD, TREX1, CASP1",0.330683119433888,0.139063379299906,FALSE
+"H1703","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.53769,-1.59,0.0519,7673,0.325,"TGFB3, ITGA11, TTN, GNAS, ITGA6, ATP2A2, ITGA1, ITGA4, ADCY9, ITGB6, ITGB4, ITGA7, TNNC1, ITGB3, SLC8A1, TGFB2, ITGA2, ITGB8",1.28483264215154,0.488116639021126,FALSE
+"H1703","Input","KEGG_DNA_REPLICATION",0.36361,1.12,0.281,4066,0.923,"RNASEH2C, RPA3, POLD4, MCM5, RFC4, POLA2, POLA1, MCM3, PCNA, POLE, POLD2, PRIM2, MCM7, MCM4, RFC2, MCM6, RFC5, RNASEH2B, RNASEH2A, PRIM1, LIG1, POLD3, MCM2, RPA2",0.55129368009492,0.0347982989740879,FALSE
+"H1703","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55424,1.69,0.0312,2068,0.606,"ETS1, NOTCH3, SPIRE1, SPIRE2, EGFR, NOTCH2",1.50584540598156,0.217527375833714,FALSE
+"H1703","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.50548,-1.49,0.0941,8388,0.407,"ALDH3A1, GSTM4, GSTM1, MAOA, GSTT2, GSTM2, MGST1",1.02641037657274,0.39040559077478,FALSE
+"H1703","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.2743,-0.815,0.673,8059,0.927,"NAT2, TYMP, CES1, CES2, CDA",0.171984935776023,0.0329202658555029,FALSE
+"H1703","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.7124,-2.09,0.00166,8151,0.123,"HSPG2, ITGA1, ITGA4, COL6A3, COL1A2, ITGB6, ITGB4, VTN, COL11A1, LAMB3, ITGA7, LAMC2, LAMA3, LAMA4, SDC1, FN1, THBS1, COL5A1, CD36, TNC, SDC2, COL6A1, LAMB1, ITGB3, COL3A1, SDC4, AGRN, ITGA2, CD44, ITGB8",2.77989191195995,0.910094888560602,TRUE
+"H1703","Input","KEGG_ENDOCYTOSIS",0.16136,0.489,0.998,676,1,"PDGFRA, PLD2, DNM1L, IQSEC1, EPN2, RAB11FIP3, VPS4B, RUFY1, RABEP1, STAM2",0.000869458712628891,0,FALSE
+"H1703","Input","KEGG_ENDOMETRIAL_CANCER",-0.40798,-1.21,0.21,7005,0.581,"TP53, MYC, PIK3CA, TCF7L2, CTNNA2, PIK3CB, PDPK1, ILK, APC, CTNNA1, HRAS, PIK3R1, CTNNB1, PIK3R2, PIK3CD, CCND1",0.677780705266081,0.235823867609669,FALSE
+"H1703","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.26972,-0.795,0.709,6469,0.923,"TJP1, JUN, ATP6V1A, ATP6V1C2, ATP6V0A2, ATP6V0C, ATP6V1B2, ATP6V0D1, ATP6V1G2, MET, TCIRG1, ATP6V1D, ATP6V1B1, LYN, ATP6V1H, JAM2, ADAM10, MAPK13, F11R, CXCL1",0.149353764816933,0.0347982989740879,FALSE
+"H1703","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.18882,-0.547,0.981,7051,1,"PTK2, MYC, PIK3CA, PAK4, TGFA, CAMK2D, PIK3CB, MAP2K7, HRAS, PIK3R1, CBLB, PIK3R2, PIK3CD, ERBB3, CDKN1A",0.0083309926200515,0,FALSE
+"H1703","Input","KEGG_ETHER_LIPID_METABOLISM",-0.26861,-0.796,0.689,7594,0.932,"PAFAH2, PLA2G4A, LPCAT2, PLPP3, CHPT1",0.161780778092374,0.0305840876460186,FALSE
+"H1703","Input","KEGG_FATTY_ACID_METABOLISM",0.28387,0.88,0.575,1424,0.975,"ALDH3A2, ACAA2, ECI1, ACAT1, CPT1A, ADH5, CPT1C, ECI2",0.24033215531037,0.0109953843014632,FALSE
+"H1703","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.44762,-1.3,0.156,7041,0.558,"PLA2G12A, RAC3, PIK3CA, LYN, PRKCD, PIK3CB, MAP2K7, PDPK1, PLA2G4A, VAV3, HRAS, PIK3R1, MAPK13, LCP2, SYK, PIK3R2, PIK3CD, INPP5D, RAC2, GAB2",0.806875401645538,0.253365801062421,FALSE
+"H1703","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.39254,-1.16,0.247,7878,0.584,"PLA2G4A, AMPH, VAV3, PTPRC, PIP5K1C, PIK3R1, PLA2G4F, MYO10, ASAP2, SYK, ARPC1A, MARCKS, PLPP3, PIK3R2, SCIN, PIK3CD, INPP5D, RAC2, GAB2, WAS",0.607303046740334,0.233587152887601,FALSE
+"H1703","Input","KEGG_FOCAL_ADHESION",-0.39802,-1.17,0.235,8188,0.578,"PIP5K1C, ITGA1, ITGA4, PIK3R1, COL6A3, PDGFRB, COL1A2, ITGB6, ITGB4, VTN, COL11A1, LAMB3, FLNC, ITGA7, LAMC2, CTNNB1, PIK3R2, LAMA3, LAMA4, PARVA, ACTN4, FN1, THBS1, COL5A1, VEGFA, TNC, COL6A1, LAMB1, ITGB3, PIK3CD, COL3A1, IGF1R, RAC2, ITGA2, CCND1, FLNB, ITGB8",0.628932137728264,0.238072161579471,FALSE
+"H1703","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.62193,-1.83,0.0281,8632,0.21,"QDPR, PTS",1.55129368009492,0.677780705266081,TRUE
+"H1703","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.2272,0.698,0.845,1679,0.966,"TPI1, PHPT1, AKR1B1, FPGT, PMM1, MTMR6, PFKFB3",0.0731432910503077,0.0150228735845067,FALSE
+"H1703","Input","KEGG_GALACTOSE_METABOLISM",-0.22831,-0.665,0.888,6436,0.979,"GALE, GAA, PGM2, HK3, PFKM, MGAM, B4GALT1",0.051587034221399,0.00921730819686218,FALSE
+"H1703","Input","KEGG_GAP_JUNCTION",0.366,1.13,0.277,1351,0.941,"PDGFRA, MAPK7, TUBB2B, PDGFC, TUBA3C, TUBB6, PLCB2, TUBA1C, TUBB1, TUBB3, ITPR2, PLCB3, TUBB, TUBB2A, RAF1",0.557520230935551,0.0264103765727431,FALSE
+"H1703","Input","KEGG_GLIOMA",-0.25689,-0.75,0.796,8076,0.925,"HRAS, PIK3R1, PDGFRB, PIK3R2, PIK3CD, IGF1R, CCND1, CDKN1A",0.0990869322623309,0.0338582672609674,FALSE
+"H1703","Input","KEGG_GLUTATHIONE_METABOLISM",-0.54723,-1.62,0.0377,8605,0.323,"GSTM4, GGT5, GSTM1, ANPEP, GPX6, GPX7, GPX1, GSTT2, GSTM2, LAP3, MGST1",1.42365864979421,0.490797477668897,FALSE
+"H1703","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.51616,-1.5,0.0829,8591,0.412,"PLPP3, DGAT1, LPL, DGKA, DGKB, LIPG, MGLL",1.08144546944973,0.385102783966865,FALSE
+"H1703","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.21067,-0.612,0.957,7873,0.996,"GPD1, PLA2G4A, GPD2, LPCAT2, PLPP3, DGKA, CHPT1, DGKB",0.0190880622231565,0.00174066157630127,FALSE
+"H1703","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.3134,0.93,0.514,1040,0.919,"SRR, PSAT1, GAMT, MAOB, PIPOX, PHGDH",0.289036881004724,0.0366844886138887,FALSE
+"H1703","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.26521,0.81,0.684,1399,0.954,"ALDH3A2, LDHB, TPI1, GAPDH, ENO1, ENO3, PGAM1, PGAM4, ADH5, PGK1, PGM1",0.164943898279884,0.0204516252959049,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.39567,-1.18,0.234,6744,0.57,"XYLT2, CHST12, B4GALT7, CHPF2, B3GAT3, CHSY1, CHST11, CHPF, CHST14",0.630784142589857,0.244125144327509,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.70026,-2.02,0.0122,6744,0.111,"XYLT2, B4GALT7, HS2ST1, B3GAT3, GLCE, EXT1, EXTL2, EXTL3, EXT2",1.91364016932525,0.954677021213343,TRUE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.73339,-2.17,0.00505,7501,0.184,"B3GNT2, B4GAT1, B4GALT3, B4GALT4, ST3GAL2, FUT8, B4GALT1",2.29670862188134,0.735182176990464,TRUE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.26112,0.795,0.705,3244,0.932,"HYAL2, HEXB, IDUA, GNS, ARSB, HEXA, HYAL1, GALNS",0.151810883008601,0.0305840876460186,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.47906,1.48,0.0816,124,0.684,"B4GALNT1",1.08830984124614,0.164943898279884,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.4598,-1.35,0.129,8348,0.523,"ST3GAL2, B3GALNT1",0.889410289700751,0.281498311132726,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.78145,-2.32,0,7501,0.137,"B3GNT2, B4GAT1, B3GNT3, ST3GAL4, B4GALT3, B4GALT4, B4GALT1",Inf,0.863279432843593,TRUE
+"H1703","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.22373,-0.669,0.906,5264,0.983,"PIGS, PIGM, GPAA1, PIGT, PIGK, PIGO, PGAP1",0.0428718023231869,0.00744648216786438,FALSE
+"H1703","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.25732,0.795,0.719,1897,0.932,"PGP, MTHFD1L, ACO2, MDH1",0.143271109617117,0.0305840876460186,FALSE
+"H1703","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.21049,0.654,0.92,1668,0.982,"MAPK7, PLD2, ATF4, MAPK9, MAP2K4, PLCB2, MAPK10, ITPR2, PLCB3, RAF1, MAPK8, PRKACA, PRKCA",0.0362121726544447,0.00788851221305034,FALSE
+"H1703","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.30363,0.932,0.507,1869,0.938,"GLI3, BTRC, PRKACA, FBXW11",0.294992040666664,0.0277971616209356,FALSE
+"H1703","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.72282,-2.13,0.00649,7834,0.12,"ITGA6, MME, CD38, ITGA1, ITGA4, EPO, IL6, CD59, CD55, CD36, ITGB3, ANPEP, ITGA2, IL1R1, CD44",2.18775530319963,0.920818753952375,TRUE
+"H1703","Input","KEGG_HISTIDINE_METABOLISM",-0.40597,-1.19,0.233,7974,0.591,"ALDH1A3, ALDH3A1, MAOA, HNMT",0.632644078973981,0.228412519118745,FALSE
+"H1703","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.42897,1.3,0.164,3182,0.742,"SEM1, BLM, RPA3, POLD4, MRE11, RAD50, EME1, POLD2, NBN, RAD54L, XRCC3",0.785156151952302,0.129596094720973,FALSE
+"H1703","Input","KEGG_HUNTINGTONS_DISEASE",0.37406,1.15,0.258,3261,0.934,"GRIN1, COX6A1, DNAH3, SOD1, COX6C, PLCB2, HIP1, NDUFA4, COX7C, PLCB3, TBPL1, DCTN4, NDUFA8, COX7A2, CASP9, SDHA, SDHB, CLTA, ATP5F1B, DCTN2, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, PPID, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, TBP, CLTB, CREB3L1, ATP5PD, IFT57, CLTC, UQCRQ, REST, UQCRC1, DCTN1, CASP3, NDUFA7, TFAM, UQCRH, BAX, NDUFC1, DNAL1, NDUFB5, POLR2H, NDUFS5, HAP1, CYCS, NDUFA2, SDHD, VDAC1, SP1, DNAL4, NDUFB1, GNAQ, NDUFC2, CASP8, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3, ATP5F1D, HTT, COX7B",0.58838029403677,0.0296531237699066,FALSE
+"H1703","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.5246,-1.55,0.0726,7673,0.36,"TGFB3, ITGA11, TTN, ITGA6, ATP2A2, ITGA1, ITGA4, ITGB6, ITGB4, ACE, ITGA7, IL6, TNNC1, ITGB3, SLC8A1, TGFB2, ITGA2, ITGB8",1.13906337929991,0.443697499232713,FALSE
+"H1703","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.28927,0.88,0.56,1591,0.975,"ISYNA1, TPI1, IMPA1, OCRL, INPP4B, PLCB2, PLCB3, PLCG2, PLCD1, INPP5K, PIK3C3, PTEN",0.2518119729938,0.0109953843014632,FALSE
+"H1703","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.25191,0.789,0.724,1865,0.91,"EIF4EBP1, CRK, ACACB, SHC1, ACACA, FLOT2, TRIP10, RPS6KB1, FLOT1, PYGL, MKNK1, MAPK9, PRKAR2B, MAPK10, RAF1, PHKA1, INPP5K, CRKL, PHKB, PRKAB2, MAPK8, FOXO1, PRKACA, SREBF1, SORBS1, INSR, RPTOR",0.140261433802853,0.0409586076789064,FALSE
+"H1703","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.58073,-1.74,0.0293,8276,0.264,"ITGA4, IL6, CXCR4, LTBR",1.53313237964589,0.578396073130169,FALSE
+"H1703","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.42412,-1.24,0.198,7033,0.588,"PTPN6, MYC, PIK3CA, JAK3, CCND3, STAT6, JAK1, PIM1, LEPR, PIK3CB, IL13RA2, STAT2, SPRY1, BCL2L1, PIK3R1, CBLB, EPO, IL6, PIK3R2, PIK3CD, CCND1, SPRY2",0.703334809738469,0.230622673923862,FALSE
+"H1703","Input","KEGG_LEISHMANIA_INFECTION",-0.40624,-1.22,0.217,8254,0.592,"C3, ITGA4, TRAF6, MAPK13, CYBA, TGFB2, PTGS2",0.66354026615147,0.22767829327708,FALSE
+"H1703","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.43134,-1.28,0.154,7584,0.579,"CTNNA2, PIK3CB, JAM2, GNAI1, VAV3, CTNNA1, ITGA4, PIK3R1, ICAM1, MAPK13, CLDN7, CTNNB1, PIK3R2, ACTN4, CLDN3, PTK2B, CYBA, PIK3CD, CTNND1, RAC2, PECAM1, MMP2, F11R, CXCR4",0.812479279163537,0.237321436272564,FALSE
+"H1703","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.56034,1.7,0.0378,110,0.726,"ALDH3A2",1.42250820016277,0.139063379299906,FALSE
+"H1703","Input","KEGG_LONG_TERM_DEPRESSION",-0.34395,-1.02,0.406,7041,0.664,"PLA2G12A, GNAI3, PLCB4, PPP2CB, GNA12, GUCY1A1, LYN, GNA11, GNAI1, GNAS, PLA2G4A, ITPR3, HRAS, PRKG1, IGF1R",0.391473966422806,0.177831920631982,FALSE
+"H1703","Input","KEGG_LONG_TERM_POTENTIATION",0.27941,0.845,0.609,2911,0.973,"GRIN1, ATF4, RPS6KA1, PLCB2, ITPR2, PLCB3, RAF1, PRKACA, PRKCA, RPS6KA2, CAMK2G, CALML3, MAP2K2, PRKCB, CALM2, RPS6KA3, GNAQ",0.215382707367125,0.0118871597316481,FALSE
+"H1703","Input","KEGG_LYSINE_DEGRADATION",-0.27807,-0.83,0.703,7276,0.93,"SUV39H1, DLST, NSD2, SUV39H2, DOT1L, SETD7, PLOD1, PLOD2, AASS",0.153044674980176,0.0315170514460649,FALSE
+"H1703","Input","KEGG_LYSOSOME",0.28238,0.854,0.602,1885,0.996,"MCOLN1, NAGA, SUMF1, GGA2, CTSK, CTSO, IGF2R, CTSL, LAMP3, SLC17A5, PSAPL1, CTSG, CLN5, ARSA, GLA, LAMP2, AP1S1, AP1S2, AP3M1, CLTA, AP3S1, AGA, NPC2, PSAP, GGA3, DNASE2, M6PR, AP1M1, AP3B1, AP3D1, HEXB",0.220403508742175,0.00174066157630127,FALSE
+"H1703","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26549,0.817,0.659,2486,0.978,"PDGFRA, MEF2C, TGFBR2, HSPB1, MAPK7, CACNA2D1, MAP3K20, CRK, RELB, NFKB2, ATF4, MKNK1, MAPK9, RPS6KA1, TNFRSF1A, IL1A, MAP2K4, MAPK10, TGFB1, STMN1, IKBKG, NF1, PPM1B, RAF1, RELA, MAPT, MAP3K7, CRKL, MAPK8, ARRB2, TAB2, PRKACA, PRKCA, RPS6KA2, TAB1, EGFR, PAK1, TRAF2, HSPA1A, TAOK1, AKT1, PAK2, MOS, MAPK12, FLNA, HSPA6, CASP3, MAP2K2, HSPA2, RRAS, RASA1, NFKB1, DUSP3",0.18111458540599,0.00966114521239857,FALSE
+"H1703","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.47615,-1.41,0.116,7844,0.475,"HNF1B, PDX1, HNF1A, HNF4A",0.935542010773082,0.323306390375133,FALSE
+"H1703","Input","KEGG_MELANOGENESIS",-0.21183,-0.626,0.926,6828,0.993,"CREBBP, GNAO1, DVL3, DVL1, GNAI3, PLCB4, WNT5A, TCF7L2, CAMK2D, GNAI1, GNAS, HRAS, MITF, ADCY9, CTNNB1",0.0333890133180656,0.00305075150461883,FALSE
+"H1703","Input","KEGG_MELANOMA",-0.30701,-0.899,0.577,8076,0.823,"HRAS, MITF, PIK3R1, PDGFRB, PIK3R2, PIK3CD, IGF1R, CCND1, CDKN1A",0.238824186844269,0.0846001647877302,FALSE
+"H1703","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.54709,-1.63,0.0505,7974,0.331,"ALDH1A3, AKR1C1, ALDH3A1, GSTM4, CYP2S1, GSTM1, GSTT2, GSTM2, MGST1",1.29670862188134,0.480172006224281,FALSE
+"H1703","Input","KEGG_MISMATCH_REPAIR",0.5492,1.62,0.0618,1950,0.553,"PMS2, MSH6, MLH1, MSH2, MSH3, RPA3, POLD4, RFC4",1.20901152491118,0.257274868695302,FALSE
+"H1703","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.23104,-0.698,0.869,7171,0.982,"PIK3CA, CAB39, RPS6, PIK3CB, PDPK1, VEGFC, PIK3R1, PIK3R2, VEGFA, PIK3CD",0.0609802235513335,0.00788851221305034,FALSE
+"H1703","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.37381,-1.11,0.304,7033,0.607,"PTPN6, RAC3, PPP3R1, ITGB2, PIK3CA, RAET1L, ULBP2, PPP3CA, PPP3CC, PIK3CB, TNFRSF10B, VAV3, HRAS, PIK3R1, ICAM1, LCP2, ICAM2, SYK, PIK3R2, PTK2B, PIK3CD, RAC2, NFATC4",0.517126416391246,0.216811308924742,FALSE
+"H1703","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.50978,1.55,0.0775,1974,0.613,"GRIN1, CTSG, NR3C1, TACR1, PLG, PRSS1, HRH1",1.11069829749369,0.212539525481585,FALSE
+"H1703","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24435,0.774,0.748,2459,0.924,"NGFR, MAPK7, CRK, SHC1, ATF4, NFKBIE, YWHAH, MAPK9, RPS6KA1, MAPK10, FOXO3, YWHAE, NFKBIB, PLCG2, RAF1, RELA, CRKL, MAPK8, RPS6KA2, KIDINS220, YWHAG, AKT1, YWHAQ, CAMK2G, MAPK12, YWHAB, CALML3, BAX, MAP2K2, NFKB1, BAD",0.126098402135539,0.0343280287798933,FALSE
+"H1703","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.3463,-1.03,0.39,7317,0.655,"PNP, QPRT, NT5C3A, CD38, NT5E, NNT",0.408935392973501,0.183758700008217,FALSE
+"H1703","Input","KEGG_NITROGEN_METABOLISM",0.38064,1.2,0.22,308,0.843,"GLUL, CA13, ASNS, GLUD2",0.657577319177794,0.0741724253752577,FALSE
+"H1703","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.41018,-1.21,0.223,8387,0.581,"TRAF6, MAPK13, IL6, PYCARD, CASP1, TRIP6, CXCL1",0.651695136951839,0.235823867609669,FALSE
+"H1703","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.45191,1.39,0.117,2726,0.751,"MRE11, XRCC4, LIG4, RAD50, POLL",0.931814138253838,0.124360062995832,FALSE
+"H1703","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.27123,-0.815,0.697,7005,0.927,"TP53, PIK3CA, TGFA, CDK4, RXRA, PIK3CB, PDPK1, HRAS, PIK3R1, PIK3R2, PIK3CD, CCND1",0.156767221901991,0.0329202658555029,FALSE
+"H1703","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.26355,0.81,0.665,869,0.954,"NOTCH3, DVL2, NUMBL, PSEN2, MAML2",0.177178354696895,0.0204516252959049,FALSE
+"H1703","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.19425,-0.578,0.978,6228,1,"CCNH, MNAT1, RFC1, DDB2, XPC, GTF2H5, GTF2H4, CDK7, POLE4, ERCC2, ERCC3, GTF2H2, GTF2H3, ERCC5, GTF2H1",0.00966114521239857,0,FALSE
+"H1703","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.45106,-1.33,0.14,5851,0.541,"MGAT1, ALG11, DAD1, DDOST, TUSC3, RPN2, ALG14, DPM3, ALG1, MGAT3, MGAT2, ALG9, MOGS, MAN2A1, MAN2A2, MAN1A1, MAN1A2, MAN1B1, B4GALT3, DOLPP1, FUT8, MGAT5, B4GALT1",0.853871964321762,0.266802734893431,FALSE
+"H1703","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.23261,-0.686,0.893,6762,0.98,"PDC, CNGB1, CAMK2D, PRKG1",0.0491485411114536,0.00877392430750515,FALSE
+"H1703","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.36991,1.11,0.268,1729,0.908,"MTHFD1L, ATIC, GART, SHMT1",0.571865205971211,0.0419141514789149,FALSE
+"H1703","Input","KEGG_OOCYTE_MEIOSIS",0.17911,0.541,0.995,2435,1,"CDC25C, PTTG1, YWHAH, RPS6KA1, ITPR2, YWHAE, PPP2R5D, BTRC, ESPL1, CDC26, PRKACA, RPS6KA2, FBXW11, YWHAG, MOS, YWHAQ, CAMK2G, MAPK12, YWHAB, CDK1, CALML3, ANAPC4",0.00217691925427455,0,FALSE
+"H1703","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.31633,0.958,0.428,3060,0.9,"MAN2B2, AGA, HEXB, MAN2B1, HEXA",0.368556230986828,0.0457574905606751,FALSE
+"H1703","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.36588,1.09,0.325,3387,0.848,"COX6A1, COX6C, LHPP, COX11, NDUFA4, COX7C, NDUFA11, COX15, NDUFA8, COX7A2, SDHA, SDHB, ATP5F1B, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, ATP5PD, UQCRQ, UQCRC1, NDUFA7, UQCRH, NDUFC1, NDUFB5, NDUFS5, NDUFA2, SDHD, NDUFB1, NDUFC2, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3, PPA1, ATP5F1D, COX7B, ATP5PF, UQCR10, ATP5ME",0.488116639021126,0.0716041477432862,FALSE
+"H1703","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.73514,-2.16,0.00321,7562,0.131,"GALNT12, C1GALT1, B3GNT6, GALNT11, GALNT4, GALNT1, GALNT13, GALNT15, GALNT7, ST3GAL2, GALNT2, GCNT1, GALNT5, B4GALT5, GALNT3, GALNT6",2.49349496759513,0.882728704344236,TRUE
+"H1703","Input","KEGG_P53_SIGNALING_PATHWAY",-0.28371,-0.84,0.636,7461,0.92,"CCNB2, CDK4, PMAIP1, TNFRSF10B, SFN, RCHY1, IGFBP3, THBS1, SERPINB5, CCND1, CDKN1A",0.196542884351586,0.0362121726544447,FALSE
+"H1703","Input","KEGG_PANCREATIC_CANCER",-0.26446,-0.774,0.744,7005,0.922,"TP53, RAC3, RAD51, PIK3CA, TGFA, JAK1, CDK4, PIK3CB, TGFB3, TGFBR1, RALB, VEGFC, BCL2L1, PIK3R1, PIK3R2, VEGFA, PIK3CD, TGFB2, RAC2, CCND1",0.128427064454121,0.0352690789463706,FALSE
+"H1703","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.23482,-0.686,0.854,2169,0.98,"PPCS, PPCDC, PANK2, DPYD, COASY, PANK4, BCAT2",0.068542129310995,0.00877392430750515,FALSE
+"H1703","Input","KEGG_PARKINSONS_DISEASE",0.4569,1.37,0.121,3141,0.68,"UCHL1, UBE2G1, SLC18A1, COX6A1, UBE2L6, COX6C, NDUFA4, COX7C, NDUFA8, COX7A2, CASP9, SDHA, SDHB, ATP5F1B, UBE2L3, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, PPID, CYC1, COX4I1, PARK7, UQCRFS1, COX7A2L, COX6B1, LRRK2, ATP5PD, UQCRQ, UQCRC1, CASP3, NDUFA7, UQCRH, NDUFC1, NDUFB5, NDUFS5, CYCS, NDUFA2, SDHD, VDAC1, NDUFB1, NDUFC2, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3",0.91721462968355,0.167491087293764,FALSE
+"H1703","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.33129,-0.974,0.442,8560,0.726,"ARPC1A, HCLS1, CTNNB1, TUBA4A, WAS",0.354577730650908,0.139063379299906,FALSE
+"H1703","Input","KEGG_PATHWAYS_IN_CANCER",-0.24668,-0.731,0.797,7516,0.948,"SKP2, TPR, CDK4, RXRA, CTNNA2, PIK3CB, TGFB3, TGFBR1, RALB, APC, PAX8, VEGFC, ITGA6, HSP90B1, CTNNA1, BCL2L1, HRAS, MITF, PIK3R1, PDGFRB, CBLB, TRAF6, LAMB3, LAMC2, IL6, CTNNB1, PIK3R2, LAMA3, LAMA4, FN1, VEGFA, LAMB1, PIK3CD, MECOM, TGFB2, IGF1R, RAC2, ITGA2, MMP2, CCND1, RUNX1, SLC2A1, CDKN1A, PTGS2",0.0985416786038876,0.0231916626619338,FALSE
+"H1703","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.3191,0.972,0.448,2088,0.89,"RPE, AKR1B1, CRYL1, XYLB",0.348721986001856,0.0506099933550872,FALSE
+"H1703","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.27783,0.837,0.616,1399,0.972,"PGLS, DERA, PRPS1, PRPS1L1, PGD, RPE, PGM1",0.210419287835575,0.0123337350737254,FALSE
+"H1703","Input","KEGG_PEROXISOME",-0.35685,-1.04,0.359,7236,0.645,"NUDT19, ACOX3, ACSL5, PEX11B, ACSL1, ACOX1, ACSL3, MLYCD, ABCD4, ACOT8, MVK, ACSL6, PXMP2, PEX12, AMACR, PEX13, ABCD3, CROT, ACOX2, CAT, CRAT, ACSL4, FAR1, EPHX2, SLC27A2",0.444905551421681,0.190440285364732,FALSE
+"H1703","Input","KEGG_PHENYLALANINE_METABOLISM",-0.35798,-1.06,0.347,7974,0.638,"ALDH1A3, PAH, ALDH3A1, MAOA",0.459670525209126,0.195179321278838,FALSE
+"H1703","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.26122,-0.788,0.72,7140,0.927,"PLCB4, PIK3CA, DGKZ, INPP5A, PIP4K2A, PIK3CB, ITPR3, PI4KA, ITPK1, PIP5K1C, PIK3R1, PIK3C2A, PIK3R2, DGKA, DGKB, PIK3CD, INPP5D",0.142667503568732,0.0329202658555029,FALSE
+"H1703","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.61064,1.96,0.0073,1405,0.366,"HMOX1, FECH, UROS, BLVRA, HMBS, COX15, BLVRB, CP",2.13667713987954,0.436518914605589,FALSE
+"H1703","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.5948,-1.77,0.0308,7193,0.253,"CPT2, ACOX3, ACSL5, ACSL1, ACOX1, ACSL3, GK, RXRA, PDPK1, ILK, ACSL6, SLC27A4, ACOX2, FABP1, ACSL4, FABP3, PCK1, CYP27A1, FABP2, LPL, HMGCS2, CD36, FADS2, APOC3, SLC27A2, FABP7, ME1",1.51144928349956,0.596879478824182,FALSE
+"H1703","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.55766,-1.7,0.0375,7947,0.288,"AMACR, ACOX2, CYP27A1, AKR1D1",1.42596873227228,0.540607512240769,FALSE
+"H1703","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.70651,2.18,0.0049,929,0.362,"CD40, TAP1, ADA, RFXAP, TAP2, RFXANK, IKBKG",2.30980391997149,0.441291429466834,FALSE
+"H1703","Input","KEGG_PRION_DISEASES",-0.25636,-0.75,0.756,8198,0.925,"C9, IL6, NCAM1",0.121478204498793,0.0338582672609674,FALSE
+"H1703","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.22266,-0.66,0.91,7461,0.975,"CCNB2, PIK3CB, GNAI1, BUB1, ADCY9, PIK3R1, MAPK13, PIK3R2, PIK3CD, IGF1R",0.0409586076789064,0.0109953843014632,FALSE
+"H1703","Input","KEGG_PROPANOATE_METABOLISM",0.32583,1.01,0.403,387,0.9,"ALDH3A2, LDHB, ACACB, ACACA",0.39469495385889,0.0457574905606751,FALSE
+"H1703","Input","KEGG_PROSTATE_CANCER",0.22788,0.703,0.859,587,0.974,"PDGFRA, GSTP1, ATF4, E2F3, PDGFC, RB1",0.0660068361687577,0.0114410431213845,FALSE
+"H1703","Input","KEGG_PROTEASOME",0.26847,0.829,0.669,695,0.971,"PSMB9, SEM1, PSMB8, PSMB10",0.174573882232177,0.0127807700919951,FALSE
+"H1703","Input","KEGG_PROTEIN_EXPORT",-0.36121,-1.06,0.336,6678,0.638,"SEC11A, SEC61A1, HSPA5, SPCS2, SPCS3, SEC11C, SPCS1",0.473660722610156,0.195179321278838,FALSE
+"H1703","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.56241,-1.64,0.0609,8281,0.34,"ATP1A2, GLS, GLS2, PCK1, AQP1, SLC38A3",1.21538270736712,0.468521082957745,FALSE
+"H1703","Input","KEGG_PURINE_METABOLISM",0.22486,0.692,0.867,2422,0.961,"PFAS, ADK, PDE6C, NME1, ADA, RRM2B, NUDT9, NUDT5, NT5C2, PRPS1, PRPS1L1, NME2, IMPDH2, NME3, ATIC, HPRT1, ADSL, GART, PAPSS2, DCK, POLD4, GMPS, PRPS2, GUK1, NUDT2, APRT, NME4, ITPA, NT5C, POLA2, FHIT, POLA1, POLR3G, PAICS",0.0619809025237897,0.0172766123314547,FALSE
+"H1703","Input","KEGG_PYRIMIDINE_METABOLISM",0.21544,0.657,0.911,2369,0.994,"UPP1, TXNRD1, UPRT, NME1, RRM2B, NT5C2, NME2, NME3, DTYMK, CAD, DUT, DCK, DCTD, TK1, TK2, POLD4, NUDT2, NME4, ITPA, NT5C, POLA2, POLA1, POLR3G",0.0404816230270017,0.00261361560268669,FALSE
+"H1703","Input","KEGG_PYRUVATE_METABOLISM",0.32341,0.983,0.425,1365,0.888,"ALDH3A2, LDHB, ACACB, ACACA, ME2, ACYP1, ACAT1, ACYP2, GLO1, AKR1B1",0.371611069949688,0.051587034221399,FALSE
+"H1703","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.29383,-0.888,0.569,8034,0.835,"MYH14, HRAS, PIP5K1C, ITGA1, IQGAP3, ITGA4, PIK3R1, PDGFRB, ITGB6, ITGB4, RRAS2, ARPC1A, ITGA7, PIK3R2, IQGAP2, ACTN4, SLC9A1, FN1, SCIN, ITGB3, PIK3CD, RAC2, ITGA2, WAS, ITGB8",0.244887733604929,0.0783135245163979,FALSE
+"H1703","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.44189,1.35,0.126,1681,0.676,"ATG12, ATG5, GABARAPL1, PIK3C3, ATG7, PIK3R4",0.899629454882437,0.170053304058364,FALSE
+"H1703","Input","KEGG_RENAL_CELL_CARCINOMA",-0.25915,-0.769,0.748,6518,0.921,"JUN, HGF, SOS1, RAPGEF1, CREBBP, RAP1B, PIK3CA, MET, PAK4, TGFA, RAP1A, PIK3CB, TGFB3, VEGFC, HRAS, PIK3R1, PIK3R2, VEGFA, PIK3CD, TGFB2, SLC2A1",0.126098402135539,0.0357403698031511,FALSE
+"H1703","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.39302,-1.14,0.293,7917,0.584,"MME, ACE, ANPEP",0.533132379645891,0.233587152887601,FALSE
+"H1703","Input","KEGG_RETINOL_METABOLISM",-0.45263,-1.36,0.137,8665,0.524,"DGAT1, PNPLA4, DHRS3, RDH10",0.863279432843593,0.280668713016273,FALSE
+"H1703","Input","KEGG_RIBOFLAVIN_METABOLISM",0.64005,1.97,0.0127,1663,0.532,"ACP6, PHPT1, MTMR6",1.89619627904404,0.274088367704952,FALSE
+"H1703","Input","KEGG_RIBOSOME",0.12821,0.394,1,6734,1,"RPS4Y1, RPS29, RPL37, RPL38, RPS21, RPS12, RPS28, RPS3, RPL24, RSL24D1, RPS10, RPL17, RPL36A, RPL36AL, UBA52, RPS5, RPSA, RPS19, RPL10A, FAU, RPL18, RPL12, RPL13A, RPL29, RPS17, RPL35A, RPS15A, RPS15, RPL23, RPS27L, RPL30, RPLP0, RPS9, RPS13, RPL9, RPL22, RPL18A, RPS16, RPS2, RPL3, RPLP1, RPS20, RPL28, RPS24, RPL10, RPL15, RPL6, RPL11, RPL27, RPL7A, RPL4, RPS11, RPL8, RPL26, RPS27A, RPL31, RPL7, RPL34, RPS4X, RPLP2, RPS25, RPL36, RPS23, RPL27A, RPS7, RPL23A, RPS18, RPS8, RPS26, RPL21, MRPL13, RPL13, RPL26L1, RPS3A, RPL5, RPL19, RPL35, RPL37A, RPL32",0,0,FALSE
+"H1703","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45927,1.38,0.106,2218,0.713,"DDX3Y, AZI2, ATG12, TBKBP1, MAPK9, RIPK1, MAPK10, IKBKG, NFKBIB, RELA, MAP3K7, ATG5, MAPK8, TBK1, DHX58, TANK, TRAF2, SIKE1, IRF3, TRADD, MAPK12",0.97469413473523,0.146910470148134,FALSE
+"H1703","Input","KEGG_RNA_DEGRADATION",0.1837,0.565,0.98,1959,1,"LSM1, ENO1, DCP1B, ENO3, HSPA9, XRN1, LSM6, DCP2, LSM2, LSM7, LSM3",0.00877392430750515,0,FALSE
+"H1703","Input","KEGG_RNA_POLYMERASE",-0.42494,-1.25,0.19,5770,0.584,"POLR2B, POLR3C, POLR2I, POLR2E, POLR2D, POLR2L, POLR1E, POLR2F, POLR3D, POLR3H, POLR3A, POLR3K, POLR3B",0.721246399047171,0.233587152887601,FALSE
+"H1703","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.38246,-1.12,0.29,8174,0.611,"GGT7, GGT5, MARS2, CTH",0.537602002101044,0.213958789757446,FALSE
+"H1703","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.42096,-1.25,0.163,7516,0.584,"SKP2, CDK4, RXRA, PIK3CB, ITGA6, BCL2L1, PIK3R1, TRAF6, LAMB3, LAMC2, PIK3R2, LAMA3, LAMA4, FN1, LAMB1, PIK3CD, ITGA2, CCND1, PTGS2",0.787812395596042,0.233587152887601,FALSE
+"H1703","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.54227,-1.59,0.0606,7091,0.325,"STX12, STX16, GOSR1, VTI1A, STX5, VAMP4, STX10, STX18, SEC22B, SNAP23, STX3, BET1L, VAMP5, VAMP8",1.21752737583371,0.488116639021126,FALSE
+"H1703","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2792,-0.812,0.667,8252,0.921,"SMPD1, ASAH1, PLPP3, SMPD3",0.175874166083451,0.0357403698031511,FALSE
+"H1703","Input","KEGG_SPLICEOSOME",0.3247,0.985,0.433,3774,0.909,"WBP11, PQBP1, ZMAT2, LSM6, SF3B4, SLU7, RBM8A, DHX8, CHERP, LSM2, PPIL1, LSM7, LSM3, HSPA1A, SNW1, LSM4, SMNDC1, HSPA6, SNRNP40, ACIN1, SF3A2, HSPA2, PRPF8, CDC40, SNRNP70, SRSF5, CWC15, ISY1, THOC2, SYF2, THOC1, AQR, MAGOHB, TCERG1, U2AF1, SNRNP27, U2AF2, TXNL4A, HNRNPC, SNRPC, PPIH, ALYREF, HSPA1L, RBMX, THOC3, EFTUD2, CCDC12, PPIE, RBM17, SNRPG, SART1, BUD31, SRSF9, SNRPF, HSPA8, DDX23, BCAS2, PRPF3, SRSF2, SRSF1, LSM8",0.363512103646635,0.0414361167780325,FALSE
+"H1703","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.32918,-0.966,0.47,5743,0.701,"GCK, HK2, PYGB, GBE1, AGL, GAA, PGM2, HK3, GYS1, UXS1, MGAM, UGDH, PGM2L1",0.327902142064283,0.154281982033341,FALSE
+"H1703","Input","KEGG_STEROID_BIOSYNTHESIS",-0.64893,-1.88,0.0186,7678,0.204,"SC5D, LSS, DHCR7, HSD17B7, DHCR24, SQLE, MSMO1, CYP51A1, FDFT1, TM7SF2",1.73048705578208,0.690369832574101,TRUE
+"H1703","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.70082,-2.05,0.00338,6972,0.127,"HSD11B2, SRD5A3, AKR1C3, STS, HSD17B7, AKR1C1, HSD17B12, CYP21A2, AKR1D1, HSD17B8",2.47108329972235,0.896196279044043,TRUE
+"H1703","Input","KEGG_SULFUR_METABOLISM",-0.35586,-1.06,0.343,8090,0.638,"CHST11, SULT1A3",0.464705879957229,0.195179321278838,FALSE
+"H1703","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.41474,1.29,0.177,14,0.716,"CD40",0.752026733638193,0.145086977692144,FALSE
+"H1703","Input","KEGG_TASTE_TRANSDUCTION",-0.32505,-0.968,0.461,7312,0.708,"GNB1, GNB3, GNAS, ITPR3",0.336299074610352,0.149966742310231,FALSE
+"H1703","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.36951,-1.1,0.315,7734,0.615,"MVK, HMGCR, HMGCS1, HMGCS2",0.501689446210399,0.211124884224583,FALSE
+"H1703","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.20776,0.647,0.935,1281,0.975,"TGFBR2, ZFYVE16, E2F5, RPS6KB1, TGFB1, AMH, SMAD4",0.0291883891274822,0.0109953843014632,FALSE
+"H1703","Input","KEGG_THYROID_CANCER",-0.40355,-1.18,0.225,7005,0.57,"TP53, MYC, TCF7L2, TPR, RXRA, PAX8, HRAS, CTNNB1, CCND1",0.647817481888638,0.244125144327509,FALSE
+"H1703","Input","KEGG_TIGHT_JUNCTION",-0.34659,-1.01,0.402,7360,0.673,"PPP2R2A, PRKCD, PPP2R2B, CDK4, RAB3B, PRKCI, CTNNA2, JAM2, GNAI1, PARD6B, CTNNA1, CASK, MYH14, MYH7B, HRAS, SPTAN1, PARD6G, RRAS2, CLDN7, HCLS1, CTNNB1, ACTN4, CLDN3, LLGL2, TJP2, EPB41L3, EPB41L1, F11R",0.39577394691553,0.171984935776023,FALSE
+"H1703","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.28064,0.847,0.605,1854,0.991,"CD40, TLR3, CTSK, MAPK9, RIPK1, MAP2K4, MAPK10, IKBKG, MYD88, RELA, MAP3K7, MAPK8, TAB2, TAB1, TBK1",0.218244625347531,0.00392634551472468,FALSE
+"H1703","Input","KEGG_TRYPTOPHAN_METABOLISM",0.45205,1.4,0.115,325,0.799,"KYNU, ALDH3A2, MAOB",0.939302159646388,0.0974532206860086,FALSE
+"H1703","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.38145,-1.14,0.274,6958,0.584,"HK3, PIK3CA, PKM, PRKCD, IRS2, PIK3CB, PDX1, PIK3R1, IRS1, PIK3R2, PIK3CD",0.562249437179612,0.233587152887601,FALSE
+"H1703","Input","KEGG_TYROSINE_METABOLISM",0.335,1.03,0.38,2077,0.981,"MAOB, FAH, PNMT, GSTZ1, MIF, ADH5, GOT1, LCMT1, DCT",0.42021640338319,0.0083309926200515,FALSE
+"H1703","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.2842,-0.848,0.627,7033,0.914,"PTPN6, PPP3R1, PIK3CA, PAK4, TEC, PPP3CA, PPP3CC, CDK4, PIK3CB, MAP2K7, PDPK1, VAV3, PTPRC, HRAS, PIK3R1, CBLB, DLG1, MAPK13, LCP2, PIK3R2, PIK3CD, NFATC4",0.202732459169284,0.0390538042661686,FALSE
+"H1703","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.25608,0.791,0.703,2750,0.923,"FBXO2, HERC4, VHL, UBE2G1, UBE2L6, FBXW7, ERCC8, XIAP, UBE2E1, UBE2R2, CUL4B, BIRC6, BTRC, UBE2K, UBE2L3, UBE2E2, CDC26, NEDD4L, CUL4A, CUL3, UBE3B, UBE2A, UBE2M, UBE2D4, FBXW11, PIAS4, FBXW8, CUL7, UBE2D2, SMURF2, ANAPC4, PIAS2, SAE1, NEDD4, UBE2H, SKP1, ELOB, UBA6, CUL1",0.153044674980176,0.0347982989740879,FALSE
+"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.26856,-0.782,0.703,2481,0.917,"VARS2, IARS2, PDHB, PDHA1, LARS2, BCAT2",0.153044674980176,0.0376306643299789,FALSE
+"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.33257,-0.97,0.425,7790,0.714,"BCAT2, HMGCS1, HIBCH, DBT, ABAT, HMGCS2, ALDH6A1, ACADS",0.371611069949688,0.146301788223826,FALSE
+"H1703","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.21836,-0.641,0.912,7041,0.987,"PLA2G12A, PLCB4, MYLK3, ARHGEF12, GNA12, GUCY1A1, PRKCD, MYLK, GNA11, GNAS, PLA2G4A, ITPR3, PPP1R12B, ADCY9, PRKG1",0.0400051616715838,0.00568284733036327,FALSE
+"H1703","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33192,1.02,0.385,1667,0.937,"DYNC1I2, DYNC1I1, DYNC1LI1, DCTN6, DCTN5, DYNC1LI2, DCTN4, DYNC1H1, DYNC2LI1, DCTN2, PRKACA",0.414539270491499,0.0282604091122217,FALSE
+"H1703","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.41155,-1.23,0.207,7041,0.589,"PLA2G12A, PTK2, RAC3, PPP3R1, PIK3CA, PPP3CA, PPP3CC, PIK3CB, PLA2G4A, HRAS, PIK3R1, MAPK13, PIK3R2, VEGFA, PIK3CD, RAC2, NFATC4, PTGS2",0.684029654543082,0.229884705212898,FALSE
+"H1703","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.43289,-1.27,0.187,6031,0.579,"ATP6V1F, SLC12A2, SEC61B, ATP6V1E1, TJP1, ATP6V1A, ATP6V1C2, SEC61A1, ATP6V0A2, ATP6V0C, ATP6V1B2, ATP6V0D1, ATP6V1G2, TCIRG1, ATP6V1D, ATP6V1B1, ATP6V1H, GNAS, PDIA4, ERO1A, ADCY9, TJP2",0.728158393463501,0.237321436272564,FALSE
+"H1703","Input","KEGG_VIRAL_MYOCARDITIS",0.33545,1.01,0.403,1754,0.9,"CD40, CAV1, CXADR, MYH3, CASP9, SGCB, BID, DAG1, MYH10, MYH11, MYH9",0.39469495385889,0.0457574905606751,FALSE
+"H1703","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.26004,-0.784,0.741,6430,0.923,"PPP2R5B, PPP2R1B, TBL1XR1, TCF7L1, JUN, CTBP2, VANGL1, CSNK1A1, PPP2R5E, CREBBP, DVL3, TP53, DVL1, RAC3, PPP3R1, MYC, PLCB4, WNT5A, PPP2CB, TCF7L2, CCND3, PPP3CA, TBL1X, PPP3CC, CAMK2D, APC, CSNK1E, FOSL1, SOX17, PPP2R5C, SENP2, DAAM1, CTNNB1, RAC2, NFATC4, CCND1",0.130181792020672,0.0347982989740879,FALSE
+"H460","Input","KEGG_ABC_TRANSPORTERS",0.55065,1.81,0.0299,931,0.205,"ABCG2, ABCC2, ABCC3, ABCB6, ABCB10, ABCD4, ABCG1, ABCA3",1.52432881167557,0.688246138944246,TRUE
+"H460","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.53944,-1.7,0.0332,6979,0.463,"MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, IKBKB, RPS6KB2, TCF7L2, MAPK1, RARA, PIK3R2, RAF1, RELA, STAT5A, MAPK3, RPS6KB1, AKT2, STAT5B, EIF4EBP1, STAT3",1.47886191629596,0.334419008982047,FALSE
+"H460","Input","KEGG_ADHERENS_JUNCTION",-0.24556,-0.781,0.715,6894,0.831,"FER, FARP2, PTPN1, RHOA, VCL, CDH1, CDC42, TCF7L2, LMO7, MAPK1, NLK, PTPRF, MAPK3, RAC2, BAIAP2, WASL, NECTIN4, PTPN6",0.145693958198919,0.080398976215889,FALSE
+"H460","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.29557,-0.966,0.457,5653,0.604,"NFKBIB, PRKAA1, NFKB1, RXRA, MTOR, ACSL3, CAMKK2, AKT3, CHUK, PRKAG1, CPT1A, PTPN11, RXRB, PRKAG2, RXRG, AKT1, PRKCQ, STK11, IKBKB, CD36, RELA, ACACB, AKT2, IRS1, STAT3",0.34008379993015,0.218963061378868,FALSE
+"H460","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.26943,0.837,0.606,1174,0.786,"CPS1, GLS, GLS2, GPT2",0.217527375833714,0.104577453960592,FALSE
+"H460","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.30467,-1,0.426,6398,0.57,"KRAS, ATP1A4, ATP1A1, ATP1A3, NEDD4L, PIK3CA, PIK3CB, MAPK1, PIK3R2, MAPK3, IRS1",0.370590400897281,0.244125144327509,FALSE
+"H460","Input","KEGG_ALZHEIMERS_DISEASE",0.41924,1.38,0.102,2562,0.387,"ATP5PF, ITPR1, NDUFS6, ATP5PD, HSD17B10, UQCRH, CASP7, ATP5F1D, PLCB4, NDUFA2, NDUFS8, SNCA, NDUFA8, TNFRSF1A, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, APP, NDUFA7, COX5B, COX6B1, COX6A1, NDUFS1, UQCRC1, NDUFA5, ADAM17, NDUFA3, NCSTN, ERN1, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, CALM2, NDUFB8, ATP5F1E, ATP5PB, GNAQ, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, NDUFV1, ATP5MC2, UQCR10, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, ADAM10, ATP5F1A, ATP5PO, LRP1, NDUFB6, NDUFA4L2",0.991399828238082,0.412289034981089,FALSE
+"H460","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.37902,-1.22,0.222,4549,0.447,"YARS2, HARS2, MARS2, CARS2, NARS2, SARS2, WARS2, MTFMT, FARSB, TARS2, PARS2, VARS2, FARSA, SEPSECS",0.653647025549361,0.349692476868064,FALSE
+"H460","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.48321,-1.55,0.0709,6657,0.399,"PMM1, HK2, GMDS, PGM2, UGP2, MPI, NAGK, NANP, GNPDA1, GPI, HK1, AMDHD2, FPGT, GNPNAT1, GALT, GALE, RENBP, PGM3, PGM1, UAP1",1.14935376481693,0.399027104313252,FALSE
+"H460","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.33907,-1.09,0.299,7391,0.513,"CAT, GRIN1, DAXX, PPP3CA, MAPK14, APAF1, CASP1, PPP3CB, MAPK13, MAPK12",0.52432881167557,0.289882634888184,FALSE
+"H460","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.33315,1.08,0.346,1319,0.602,"CTSL, B2M, HSPA5, PDIA3, NFYB, CTSB, RFXANK",0.460923901207223,0.220403508742175,FALSE
+"H460","Input","KEGG_APOPTOSIS",-0.23443,-0.744,0.807,7393,0.841,"PIK3CB, AKT1, IRAK4, CASP6, IKBKB, PPP3CA, RIPK1, CAPN2, PIK3R2, RELA, APAF1, PPP3CB, AKT2, CAPN1",0.0931264652779296,0.0752040042020878,FALSE
+"H460","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.34082,1.08,0.35,419,0.602,"GGT1, AKR1C3, PTGES",0.455931955649724,0.220403508742175,FALSE
+"H460","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.30204,-0.966,0.436,7377,0.604,"AMD1, SMS, ASL, CKMT1A, PRODH, PRODH2, CKB, ARG2, ARG1, GATM, AOC1, DAO, GLUD2",0.360513510731414,0.218963061378868,FALSE
+"H460","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.41446,1.31,0.148,1073,0.41,"CACNA2D1, ITGB5, DSC2, ITGAV, ITGA5, DES, LMNA, DAG1, DSG2, SGCD, ITGA6",0.829738284605043,0.387216143280265,FALSE
+"H460","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.7103,2.29,0.00211,230,0.0879,"UGDH",2.67571754470231,1.05601112492623,TRUE
+"H460","Input","KEGG_AXON_GUIDANCE",-0.37722,-1.21,0.217,7073,0.434,"PLXNC1, PAK3, ROCK1, NFATC3, RHOA, EPHA2, PAK1, PTK2, CDK5, ROCK2, PAK4, GSK3B, CFL1, ARHGEF12, CDC42, PPP3CA, NFAT5, RASA1, EFNB2, MAPK1, SLIT2, ABLIM1, PAK2, SEMA3C, MAPK3, RAC2, EPHB3, PPP3CB, NTN1, RHOD, NGEF, NFATC2, EPHB2",0.66354026615147,0.362510270487489,FALSE
+"H460","Input","KEGG_BASAL_CELL_CARCINOMA",-0.22181,-0.722,0.811,6274,0.849,"FZD7, CTNNB1, STK36, GSK3B, DVL3, TCF7L2",0.090979145788844,0.0710923097560473,FALSE
+"H460","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.36423,1.18,0.228,2507,0.51,"TAF13, GTF2A2, TAF12, TAF10, GTF2E2, GTF2A1, TAF5L, GTF2H1, TAF1, TAF6L, TAF6, TAF9, TAF4, TAF7, GTF2F2",0.642065152999546,0.292429823902064,FALSE
+"H460","Input","KEGG_BASE_EXCISION_REPAIR",0.19161,0.627,0.924,7077,0.96,"NTHL1, TDG, PARP2, POLD4, LIG3, PARP1, POLE3, XRCC1, MPG, POLD2, POLE4, POLB, FEN1, PCNA, POLD1, APEX1, POLD3, PARP4, MBD4, POLE, LIG1, UNG, HMGB1",0.0343280287798933,0.0177287669604316,FALSE
+"H460","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29499,-0.961,0.453,6104,0.597,"MLYCD, ABAT, EHHADH, SMS, DPYD",0.343901797987168,0.224025668870631,FALSE
+"H460","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.22426,-0.724,0.806,7093,0.863,"HACD2, TECR, ACOT7",0.0936649581949093,0.0639892042847904,FALSE
+"H460","Input","KEGG_BLADDER_CANCER",-0.34042,-1.1,0.305,6398,0.505,"KRAS, NRAS, MAP2K2, CDK4, MAP2K1, CDH1, THBS1, MAPK1, DAPK1, RAF1, MAPK3",0.515700160653214,0.296708621881339,FALSE
+"H460","Input","KEGG_BUTANOATE_METABOLISM",-0.3324,-1.07,0.353,7112,0.528,"AACS, EHHADH, BDH2, ACAT2, HMGCS2, ACSM3, HMGCS1, BDH1",0.452225294612177,0.277366077466188,FALSE
+"H460","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52543,-1.7,0.0518,6194,0.463,"AKT3, CHUK, KRAS, NRAS, BCL10, RAC1, MAP2K2, NFATC3, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, IKBKB, PPP3CA, NFAT5, PLCG2, MAPK1, SYK, PIK3R2, RAF1, RELA, MAPK3, RAC2, VAV2, PPP3CB, AKT2, PTPN6, NFATC2",1.28567024025477,0.334419008982047,FALSE
+"H460","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.28594,0.925,0.524,1201,0.762,"BST1, CACNA1A, ITPR1, CAMK2D, PLCB4, CAMK4, PLCD3, PRKCB, VDAC1, RYR1, PTK2B, ATP2B1",0.280668713016273,0.1180450286604,FALSE
+"H460","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.45636,1.47,0.111,2271,0.331,"CACNA2D1, UQCRH, UQCRFS1, UQCRB, ATP1A2, COX5B, COX6B1, COX6A1, UQCRC1, COX5A, CYC1, SLC8A1, UQCRC2, TPM4, COX7A2, COX7C, TPM3, TPM1, UQCR10",0.954677021213343,0.480172006224281,FALSE
+"H460","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.56014,1.85,0.0274,456,0.224,"SDC2, NRCAM, PTPRM, CD274, NCAM2, NCAM1, CD99, L1CAM, CNTN1, PDCD1LG2, JAM3, ITGAV, CD58",1.56224943717961,0.649751981665837,TRUE
+"H460","Input","KEGG_CELL_CYCLE",-0.23427,-0.75,0.778,6113,0.839,"SMAD3, TFDP1, ORC2, ANAPC4, PRKDC, BUB1B, STAG2, RBL1, HDAC1, ABL1, BUB1, PLK1, CUL1, SMC3, CDK4, YWHAB, CDC45, STAG1, GSK3B, YWHAZ, FZR1, CHEK1, CDC23, CDC16, CDK1, CCNA2, CDK2, CCNB1, TTK, PTTG1, WEE1",0.109020403010311,0.0762380391712997,FALSE
+"H460","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.41158,-1.29,0.179,6982,0.43,"HCK, GNG4, ROCK1, GRK6, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PTK2, ROCK2, PIK3CB, AKT1, GSK3B, PXN, IKBKB, CDC42, MAPK1, BCAR1, CCL15, PIK3R2, RAF1, RELA, CSK, MAPK3, RAC2, STAT1, VAV2, CCL13, GRK2, GSK3A, PRKCD, WASL, GNG5, AKT2, STAT5B, ARRB1, CCL14, STAT2, STAT3",0.747146969020107,0.366531544420413,FALSE
+"H460","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.31495,-1.02,0.352,5735,0.552,"PIK3CD, CBL, NFKB1, TGFBR2, SMAD3, AKT3, CHUK, CBLB, KRAS, NRAS, CRKL, HDAC1, ABL1, MAP2K2, PTPN11, CDK4, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, IKBKB, MECOM, MAPK1, PIK3R2, RAF1, RELA, STAT5A, MAPK3, AKT2, STAT5B",0.453457336521869,0.258060922270801,FALSE
+"H460","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.41577,1.37,0.13,2298,0.382,"PDHB, IDH3A, MDH2, SUCLG1, SUCLG2, PDHA1, SDHB, DLAT, DLST, PCK2, DLD, SDHA, ACO2, IDH3G, SDHC",0.886056647693163,0.417936637088291,FALSE
+"H460","Input","KEGG_COLORECTAL_CANCER",-0.21976,-0.722,0.82,7147,0.849,"MAP2K1, RHOA, PIK3CA, PIK3CB, AKT1, GSK3B, TCF7L2, MAPK1, PIK3R2, RAF1, MAPK3, RAC2, AKT2",0.0861861476162833,0.0710923097560473,FALSE
+"H460","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.41555,1.35,0.157,1265,0.389,"CD55, MBL2, PLAUR, F3, C9, F5, F8, PROS1, PLAU, C7",0.804100347590766,0.410050398674292,FALSE
+"H460","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.3892,-1.27,0.167,5302,0.435,"SRM, APIP, AHCYL1, LDHB, LDHA, ENOPH1, DNMT1, GOT1, AMD1, SMS, CBS, ADI1, SDS, AHCY",0.777283528852417,0.361510743045363,FALSE
+"H460","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.37916,1.24,0.184,618,0.463,"EPO, CXCL5, TNFRSF19, TNFRSF10A, TGFB2, TGFBR1, TNFRSF10B, TNFRSF1A, OSMR, CXCL6",0.735182176990464,0.334419008982047,FALSE
+"H460","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.24465,-0.781,0.723,7666,0.831,"IKBKB, PYCARD, RIPK1, RELA, ZBP1, CASP1, IL18",0.140861702705469,0.080398976215889,FALSE
+"H460","Input","KEGG_DILATED_CARDIOMYOPATHY",0.42515,1.39,0.123,2322,0.391,"CACNA2D1, TGFB2, ITGB5, ITGAV, ITGA5, DES, LMNA, DAG1, SGCD, ITGA6, ITGA10, ACTG1, SLC8A1, TGFB1, EMD, ITGB1, TPM4, TPM3, GNAS, TPM1, ACTB",0.910094888560602,0.407823242604133,FALSE
+"H460","Input","KEGG_DNA_REPLICATION",-0.19803,-0.656,0.924,4819,0.913,"POLD1, MCM2, RNASEH2B, MCM7, POLA1, POLD3, MCM4, MCM6, RNASEH1, PRIM1, POLE, RFC4, RFC2, LIG1, RFC3, RFC1, RFC5",0.0343280287798933,0.039529222465701,FALSE
+"H460","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.29715,0.945,0.454,1003,0.753,"NOTCH3, NOTCH1, NOTCH2",0.342944147142896,0.123205023799299,FALSE
+"H460","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.39322,1.28,0.165,1773,0.436,"MGST1, GSTM4, GSTM1, ALDH3A1, GSTM2, MGST2, MAOA, ADH4, ADH7, GSTK1",0.782516055786094,0.360513510731414,FALSE
+"H460","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.43429,-1.4,0.12,7379,0.461,"UPP1, HPRT1, NAT1, TK1, TK2, DPYD, TPMT, UCKL1",0.920818753952375,0.336299074610352,FALSE
+"H460","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.55457,1.8,0.0184,818,0.192,"SDC2, COL5A2, FN1, SPP1, LAMB1, HSPG2, LAMA1, LAMC1, ITGB5, LAMA5, ITGAV, ITGA5, VTN, LAMB2, THBS3, DAG1, COL6A1, COL4A6",1.73518217699046,0.71669877129645,TRUE
+"H460","Input","KEGG_ENDOCYTOSIS",-0.34822,-1.12,0.27,6029,0.507,"HSPA1A, DNM2, CHMP3, VPS4B, GIT2, VPS28, RAB5A, PARD6G, CBLB, SMAP2, IQSEC2, ARFGAP1, ARFGAP3, CHMP4A, CHMP4B, VPS25, CHMP4C, VPS37B, PIP5K1A, NEDD4L, EPS15, VTA1, RAB11A, SH3GL1, ITCH, GRK6, EHD1, EHD2, DAB2, RAB11FIP1, TRAF6, ARAP1, WWP1, IQSEC1, PDCD6IP, RAB5C, SH3GLB2, CDC42, ACAP2, SH3GLB1, CHMP2A, FGFR2, CLTC, ASAP1, SMURF2, EHD3, CHMP5, SMAP1, DNM1, LDLRAP1, CHMP2B, GRK2, ERBB3, PRKCI, ARFGAP2, ARRB1, ARAP3, DNM1L",0.568636235841013,0.294992040666664,FALSE
+"H460","Input","KEGG_ENDOMETRIAL_CANCER",-0.3979,-1.29,0.163,6194,0.43,"AKT3, CTNNB1, KRAS, NRAS, MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, CDH1, TCF7L2, MAPK1, PIK3R2, RAF1, MAPK3, AKT2",0.787812395596042,0.366531544420413,FALSE
+"H460","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.31666,-1.02,0.38,7666,0.552,"IKBKB, CDC42, PLCG2, F11R, PLCG1, MAPK14, RELA, CSK, MAPK13, MAP2K4, MAPK12",0.42021640338319,0.258060922270801,FALSE
+"H460","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.42375,-1.4,0.113,6979,0.461,"MAP2K2, PAK3, MAP2K1, PIK3CA, PAK1, SOS1, PTK2, PAK4, PIK3CB, AKT1, GSK3B, GAB1, RPS6KB2, PLCG2, MAPK1, PLCG1, PAK2, PIK3R2, RAF1, STAT5A, MAPK3, RPS6KB1, ERBB3, AKT2, STAT5B, EIF4EBP1, MAP2K4, TGFA, ABL2",0.94692155651658,0.336299074610352,FALSE
+"H460","Input","KEGG_ETHER_LIPID_METABOLISM",-0.23858,-0.761,0.742,7332,0.838,"PAFAH1B3, LPCAT4, PAFAH2, LPCAT2",0.129596094720973,0.0767559813697235,FALSE
+"H460","Input","KEGG_FATTY_ACID_METABOLISM",0.25942,0.813,0.657,1769,0.804,"ACAA2, ACADSB, ECHS1, ACADS, ECI1, ACAT1, ADH4, ADH7",0.182434630440219,0.0947439512515487,FALSE
+"H460","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.48251,-1.57,0.0503,6979,0.393,"MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, SYK, MAPK14, PIK3R2, RAF1, MAPK3, RAC2, VAV2, PRKCD, AKT2, MAPK13, MAP2K4, MAPK12",1.29843201494407,0.405607449624573,FALSE
+"H460","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.50299,-1.63,0.0526,6982,0.36,"HCK, ARPC1A, MAP2K1, PIK3CA, PAK1, PIK3CB, AKT1, ARPC4, ARPC3, CFL1, VASP, CDC42, RPS6KB2, PLCG2, SCIN, ARPC2, MAPK1, MYO10, PLCG1, SYK, PIK3R2, RAF1, ASAP1, MARCKSL1, MAPK3, RAC2, VAV2, GSN, DNM1, RPS6KB1, PRKCD, WASL, AKT2, PTPRC, MARCKS, DNM1L",1.27901425584626,0.443697499232713,FALSE
+"H460","Input","KEGG_FOCAL_ADHESION",0.27835,0.89,0.537,472,0.741,"COL5A2, FN1, SPP1, LAMB1, PIK3R3, LAMA1, LAMC1, ITGB5, LAMA5, FLNB, ITGAV, ITGA5, VTN, CAV2, LAMB2, THBS3",0.270025714300444,0.130181792020672,FALSE
+"H460","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.51655,-1.67,0.0544,7763,0.424,"DHFR, ALPG, ALPI, ALPP",1.26440110030182,0.372634143407267,FALSE
+"H460","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.4599,-1.48,0.107,6110,0.435,"MTMR1, ALDOC, PFKFB3, PFKP, PMM1, HK2, TPI1, GMDS, PFKM, MTMR6, MPI, HK1, FPGT, PFKFB2, PFKFB4, PFKL, FBP1",0.97061622231479,0.361510743045363,FALSE
+"H460","Input","KEGG_GALACTOSE_METABOLISM",-0.41733,-1.32,0.162,6503,0.432,"PFKP, HK2, PFKM, PGM2, UGP2, MGAM, HK1, GALT, GALE, PGM1, PFKL",0.790484985457369,0.364516253185088,FALSE
+"H460","Input","KEGG_GAP_JUNCTION",-0.3032,-0.982,0.423,5952,0.592,"ADCY5, TUBB4B, HTR2B, GNAI3, TUBB6, KRAS, NRAS, PRKACB, PLCB3, MAPK7, MAP2K2, MAP2K1, SOS1, TUBA1B, TUBB3, TUBB1, TUBB, MAPK1, TUBB2A, RAF1, CDK1, MAPK3, CSNK1D, TUBA1C",0.373659632624958,0.22767829327708,FALSE
+"H460","Input","KEGG_GLIOMA",-0.34386,-1.11,0.303,6979,0.506,"MAP2K2, CDK4, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.518557371497695,0.295849483160201,FALSE
+"H460","Input","KEGG_GLUTATHIONE_METABOLISM",0.24851,0.8,0.7,331,0.801,"MGST1, GGT1, GSTM4, GSTM1",0.154901959985743,0.0963674839157623,FALSE
+"H460","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.28815,-0.932,0.509,8160,0.64,"DGKA, MGLL, DGKH",0.293282217663241,0.193820026016113,FALSE
+"H460","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.34491,-1.12,0.292,7585,0.507,"LPCAT4, MBOAT2, MBOAT7, CHKB, DGKA, PCYT2, PEMT, LPCAT2, CHKA, DGKH",0.534617148551582,0.294992040666664,FALSE
+"H460","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.32315,-1.04,0.357,6143,0.553,"PSPH, SARDH, DMGDH, SRR, SHMT1, CBS, SDS, GATM, DAO",0.447331783887807,0.257274868695302,FALSE
+"H460","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.41707,-1.37,0.122,6301,0.472,"ALDOC, LDHA, GALM, PFKP, BPGM, HK2, PGAM1, PGAM4, TPI1, AKR1A1, PFKM, ADH5, PGM2, ACSS2, GPI, HK1, ADH1C, ALDH1A3, PKLR, PGM1, PFKL, FBP1, PKM",0.913640169325252,0.326058001365912,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.2905,0.935,0.54,6210,0.758,"CHPF2, CHST3, DSE, CHSY1, B3GAT3, CHPF, B4GALT7, XYLT2, B3GALT6",0.267606240177031,0.120330794367946,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.36162,-1.16,0.242,5838,0.472,"XYLT2, B3GALT6, EXTL3, NDST2, HS2ST1",0.616184634019569,0.326058001365912,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.26235,0.87,0.589,380,0.737,"ST3GAL2",0.229884705212898,0.132532512140949,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.70444,2.3,0,2263,0.168,"GNS, IDS, HEXB, HEXA, GLB1, ARSB, GUSB, IDUA, GALNS",Inf,0.774690718274137,TRUE
+"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.64575,2.05,0.0131,970,0.132,"B4GALNT1, ST3GAL2, HEXB, HEXA",1.88272870434424,0.87942606879415,TRUE
+"H460","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.50746,-1.66,0.0396,5131,0.372,"PIGK, PIGT, GPAA1, PGAP1, PIGQ, PIGH, PIGM, PIGU",1.40230481407449,0.429457060118102,FALSE
+"H460","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.23526,0.766,0.757,2095,0.849,"MTHFD2, MDH2, HAO1, ACO2",0.120904120499927,0.0710923097560473,FALSE
+"H460","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.32237,-1.03,0.362,6398,0.56,"KRAS, NRAS, MAP3K3, PRKACB, PLCB3, MAPK7, MAP2K2, MAP2K1, SOS1, CDC42, MAPK1, MMP14, MAP3K4, MAPK14, RAF1, MAPK3, PRKCD, MAPK13, MAP2K4, MAPK12, MAP3K1",0.441291429466834,0.2518119729938,FALSE
+"H460","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.33353,-1.06,0.341,7225,0.536,"STK36, GSK3B, CSNK1G2, BTRC, CSNK1A1, CSNK1D",0.467245621007502,0.27083521030723,FALSE
+"H460","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.41187,1.33,0.13,454,0.399,"CD55, EPO, ITGA5, CD14",0.886056647693163,0.399027104313252,FALSE
+"H460","Input","KEGG_HISTIDINE_METABOLISM",-0.40967,-1.33,0.146,7838,0.43,"TRMT11, METTL2B, LCMT1, ALDH1A3, HDC, AOC1",0.835647144215563,0.366531544420413,FALSE
+"H460","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.31013,1.02,0.375,2061,0.684,"SSBP1, RAD51, RAD54L, MUS81, POLD4, MRE11",0.425968732272281,0.164943898279884,FALSE
+"H460","Input","KEGG_HUNTINGTONS_DISEASE",0.4545,1.48,0.0838,2579,0.338,"ATP5PF, ITPR1, NDUFS6, ATP5PD, UQCRH, ATP5F1D, PLCB4, NDUFA2, NDUFS8, POLR2H, NDUFA8, CLTA, SOD2, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, POLR2C, NDUFA7, COX5B, COX6B1, VDAC1, CLTB, COX6A1, POLR2L, NDUFS1, POLR2D, UQCRC1, NDUFA5, NDUFA3, POLR2E, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, AP2A2, NDUFB8, ATP5F1E, POLR2I, ATP5PB, GNAQ, POLR2F, SDHA, NDUFB2, UQCRC2, COX7A2, POLR2G, NDUFA4, COX7C, AP2A1, NDUFV1, ATP5MC2, UQCR10, SLC25A6, SDHC, NDUFS5, TAF4, NDUFAB1, NDUFB3, CREB5, NDUFC1, VDAC2, ATP5F1A, ATP5PO, NDUFB6, NDUFA4L2, SIN3A, SLC25A31",1.07675598136972,0.471083299722345,FALSE
+"H460","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.43064,1.4,0.115,2003,0.398,"CACNA2D1, PRKAA2, TGFB2, ITGB5, ITGAV, ITGA5, DES, LMNA, DAG1, SGCD, ITGA6, ITGA10, ACTG1, SLC8A1, TGFB1, EMD, ITGB1, TPM4",0.939302159646388,0.400116927926312,FALSE
+"H460","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42467,-1.33,0.154,6275,0.43,"MINPP1, INPP5K, INPP4B, PIP4K2A, PIP5K1A, TPI1, PLCB3, PIK3CA, OCRL, PIK3CB, IMPA1, INPPL1, PLCG2, PLCG1, INPP1, INPP5B, PIK3C2B, SYNJ2, ISYNA1",0.812479279163537,0.366531544420413,FALSE
+"H460","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.39645,-1.3,0.167,6303,0.438,"PPP1R3D, INPP5K, PRKAG1, CBLB, KRAS, NRAS, RHEB, CRKL, HK2, PRKACB, EXOC7, ACACA, FLOT2, MAP2K2, GYS1, PTPN1, MAP2K1, PRKAG2, PIK3CA, SOS1, PIK3CB, AKT1, RPS6, GSK3B, HK1, IKBKB, RPS6KB2, PHKG2, MAPK1, PIK3R2, RAF1, PTPRF, MAPK3, PKLR, RPS6KB1, ACACB, TSC2, AKT2, PRKCI, FBP1, EIF4EBP1, IRS1, MKNK1",0.777283528852417,0.3585258894959,FALSE
+"H460","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.43838,-1.41,0.124,7000,0.484,"PTPN11, SPRY2, IRF9, PIK3CA, SOS1, IFNGR1, PIK3CB, AKT1, PIAS4, PIK3R2, STAT5A, STAT1, SPRY1, AKT2, STAT5B, SPRY4, PTPN6, STAT2, STAT3, PIAS2",0.906578314837765,0.315154638355588,FALSE
+"H460","Input","KEGG_LEISHMANIA_INFECTION",-0.52159,-1.66,0.0437,7378,0.372,"IFNGR1, TAB2, IRAK4, TRAF6, ITGA4, MAPK1, MAPK14, RELA, C3, MARCKSL1, MAPK3, STAT1, MAPK13, PTPN6, MAPK12",1.35951856302958,0.429457060118102,FALSE
+"H460","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.38753,-1.25,0.204,6642,0.443,"ICAM1, CDH5, RAC1, SIPA1, EZR, PTPN11, ROCK1, RHOA, PIK3CA, PTK2, ROCK2, PIK3CB, VCL, PXN, VASP, CDC42, PLCG2, F11R, ITGA4, ARHGAP5, BCAR1, PLCG1, MAPK14, PIK3R2, ARHGAP35, CLDN7, RAC2, VAV2, MAPK13, CLDN3, MAPK12, CLDN18",0.690369832574101,0.35359627377693,FALSE
+"H460","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.29146,0.913,0.52,789,0.755,"ECHS1",0.283996656365201,0.122053048370812,FALSE
+"H460","Input","KEGG_LONG_TERM_DEPRESSION",0.25071,0.816,0.671,951,0.812,"CACNA1A, ITPR1, PLCB4, PRKCB, RYR1",0.173277479831008,0.0904439707588247,FALSE
+"H460","Input","KEGG_LONG_TERM_POTENTIATION",0.22627,0.737,0.81,725,0.83,"ITPR1, CAMK2D, PLCB4, CAMK4, PRKCB",0.0915149811213502,0.0809219076239261,FALSE
+"H460","Input","KEGG_LYSINE_DEGRADATION",0.22704,0.741,0.799,1837,0.864,"SETD7, ECHS1, ASH1L, SETMAR, KMT5C, ACAT1, DLST, EHMT2, TMLHE",0.0974532206860086,0.0634862575211067,FALSE
+"H460","Input","KEGG_LYSOSOME",0.497,1.59,0.0685,1208,0.274,"GALC, CTSL, CTSC, CTSZ, CTSV, AGA, GLA, GNS, ASAH1, PPT1, ARSA, IDS, LAMP2, IGF2R, LAMP3, HEXB, TCIRG1, CTSK, CTSO, CLTA, PPT2, CLN3, CLTB, GAA, LAMP1, NAGA, HEXA, PSAP, CTSB, CTSE, CTSF, M6PR, SCARB2",1.16430942850757,0.562249437179612,FALSE
+"H460","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.34396,-1.11,0.304,5979,0.506,"PPM1A, MAP3K7, HSPA1A, TAOK2, DUSP3, RPS6KA4, CASP3, AKT3, TAB1, CHUK, MAP3K20, SRF, RPS6KA6, ELK4, TAOK3, KRAS, NRAS, MAPT, IL1A, CRKL, MAP3K3, PRKACB, RAC1, MAPK7, MAP2K2, DUSP1, PPM1B, RPS6KA1, MAP2K1, RELB, PAK1, SOS1, AKT1, TAB2, MAPKAPK2, TRAF6, DAXX, IKBKB, MECOM, CDC42, PPP3CA, RASA1, MAP4K3, MAPK1, MAP3K4, PAK2, NLK, MAPK14, FGFR2, RAF1, RELA, MAPK3, RAC2, PPP5C, MAP3K6, HSPB1, PPP3CB, AKT2, ARRB1, MAPK13, MAP2K4, STMN1, MAPK12, NFATC2, MAP3K1, MKNK1",0.517126416391246,0.295849483160201,FALSE
+"H460","Input","KEGG_MELANOGENESIS",-0.34364,-1.14,0.269,6174,0.493,"GNAI3, FZD7, CTNNB1, KRAS, NRAS, PRKACB, PLCB3, MAP2K2, MAP2K1, GSK3B, DVL3, TYRP1, TCF7L2, MAPK1, RAF1, MAPK3, DCT, CREB3L1, TYR",0.570247719997592,0.30715308072277,FALSE
+"H460","Input","KEGG_MELANOMA",-0.37259,-1.21,0.229,6979,0.434,"MAP2K2, CDK4, MAP2K1, PIK3CA, HGF, PIK3CB, AKT1, CDH1, MAPK1, PIK3R2, RAF1, MAPK3, AKT2",0.640164517660112,0.362510270487489,FALSE
+"H460","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.47525,1.58,0.0601,353,0.266,"MGST1, CYP1B1, AKR1C3, GSTM4, AKR1C1, GSTM1, ALDH3A1",1.22112552799726,0.575118363368933,FALSE
+"H460","Input","KEGG_MISMATCH_REPAIR",-0.256,-0.808,0.693,5360,0.8,"POLD3, MSH6, MSH2, PMS2, RFC4, RFC2, LIG1, RFC3, RFC1, RFC5",0.159266765388193,0.0969100130080564,FALSE
+"H460","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.39873,-1.27,0.179,5735,0.435,"PIK3CD, PRKAA1, STRADA, MTOR, RICTOR, AKT3, RPS6KA6, RHEB, CAB39, RPS6KA1, PIK3CA, PIK3CB, AKT1, RPS6, STK11, RPS6KB2, MAPK1, PIK3R2, MAPK3, RPS6KB1, TSC2, AKT2, EIF4EBP1",0.747146969020107,0.361510743045363,FALSE
+"H460","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.37912,-1.22,0.214,6979,0.447,"MAP2K2, PTPN11, NFATC3, MAP2K1, PIK3CA, PAK1, SOS1, IFNGR1, PIK3CB, PPP3CA, NFAT5, PLCG2, MAPK1, PLCG1, SYK, PIK3R2, RAF1, MAPK3, RAC2, VAV2, MICB, PPP3CB, PTPN6, NFATC2",0.669586226650809,0.349692476868064,FALSE
+"H460","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.22772,-0.721,0.805,6008,0.842,"ADRA2A, P2RX4, HTR2B, TSPO, GRIN1, NR3C1, P2RY2",0.0942041196321315,0.0746879085003505,FALSE
+"H460","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.4285,-1.36,0.143,6750,0.471,"RAC1, ABL1, MAPK7, MAP2K2, PTPN11, MAGED1, YWHAB, RPS6KA1, MAP2K1, RHOA, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, ARHGDIB, GAB1, YWHAZ, IRAK4, MAPKAPK2, TRAF6, IKBKB, CDC42, PLCG2, MAPK1, PLCG1, SORT1, MAPK14, PIK3R2, RAF1, RELA, CSK, MAPK3, PRKCD, AKT2, NGFR, MAPK13, IRS1, MAPK12, MAP3K1",0.844663962534938,0.326979092871104,FALSE
+"H460","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.27037,0.888,0.549,1972,0.73,"BST1, NAMPT, NT5C, ENPP1, CD38",0.260427655549908,0.136677139879544,FALSE
+"H460","Input","KEGG_NITROGEN_METABOLISM",0.37242,1.2,0.234,1024,0.493,"CPS1, CA12, GLS, GLS2",0.630784142589857,0.30715308072277,FALSE
+"H460","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.52591,-1.71,0.0332,7509,0.671,"TAB2, TRAF6, IKBKB, PYCARD, HSP90AA1, MAPK1, MAPK14, RELA, MAPK3, CCL13, HSP90AB1, CASP1, IL18, MAPK13, MAPK12",1.47886191629596,0.173277479831008,FALSE
+"H460","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.20529,-0.655,0.906,5365,0.905,"NHEJ1, XRCC6, PRKDC, DCLRE1C",0.0428718023231869,0.0433514207947967,FALSE
+"H460","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.3823,-1.24,0.191,6979,0.437,"MAP2K2, CDK4, RXRB, MAP2K1, RXRG, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.718966632752272,0.359518563029578,FALSE
+"H460","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.3435,1.11,0.302,1143,0.595,"NOTCH3, NOTCH1, NOTCH2, ADAM17, NCSTN",0.519993057042849,0.22548303427145,FALSE
+"H460","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.17053,0.555,0.97,7264,0.994,"XPA, GTF2H5, CETN2, RAD23B, POLD4, RBX1, XPC, GTF2H1, POLE3, RPA3, ERCC1, GTF2H2, DDB2, MNAT1, POLD2, CCNH, RAD23A, POLE4, RPA2, ERCC4, GTF2H3, RPA1, PCNA, DDB1, POLD1, GTF2H4, ERCC3, POLD3, ERCC2, CUL4B, ERCC5, CDK7, POLE, RFC4, RFC2, LIG1, RFC3, RFC1, CUL4A, ERCC6, RFC5",0.0132282657337552,0.00261361560268669,FALSE
+"H460","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.22316,0.737,0.8,157,0.83,"TUSC3, MGAT4B",0.0969100130080564,0.0809219076239261,FALSE
+"H460","Input","KEGG_OLFACTORY_TRANSDUCTION",0.33393,1.07,0.318,1601,0.604,"CAMK2D, CNGB1, CALM2",0.497572880015567,0.218963061378868,FALSE
+"H460","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.34095,-1.08,0.323,6197,0.52,"MTHFD1, MTHFR, GART, SHMT1, MTHFS, DHFR, ALDH1L1",0.490797477668897,0.283996656365201,FALSE
+"H460","Input","KEGG_OOCYTE_MEIOSIS",-0.37866,-1.21,0.211,6624,0.434,"PPP2R1A, PPP2CA, PRKACB, BUB1, PLK1, CUL1, SMC3, YWHAB, RPS6KA1, MAP2K1, PPP2R5C, YWHAZ, CDC23, PPP3CA, MAPK1, PPP2R5B, CDC16, BTRC, PPP2R5A, CDK1, MAPK3, PPP2R5E, PPP3CB, AURKA, PPP2R5D, FBXO5, CDK2, CCNB1, PTTG1, MAPK12",0.675717544702307,0.362510270487489,FALSE
+"H460","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.5695,1.83,0.0534,2199,0.212,"AGA, HEXB, HEXA, MAN2B2, MAN2B1, GLB1, GBA, FUCA2",1.27245874297144,0.673664139071249,FALSE
+"H460","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.54277,1.74,0.0426,2564,0.183,"ATP5PF, NDUFS6, ATP5PD, UQCRH, ATP5F1D, NDUFA2, TCIRG1, NDUFS8, NDUFA8, NDUFV2, UQCRFS1, PPA2, UQCRB, NDUFS4, ATP5F1B, ATP5ME, NDUFA7, COX5B, COX6B1, COX6A1, NDUFS1, UQCRC1, NDUFA5, NDUFA3, ATP6V1F, NDUFV3, SDHB, COX5A, COX17, CYC1, NDUFS3, NDUFB8, ATP5F1E, ATP5PB, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, ATP5MG, NDUFV1, ATP6AP1, ATP5MC2, ATP6V1E1, UQCR10, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, ATP5F1A, ATP5PO, ATP6V0C, NDUFB6, NDUFA4L2, ATP6V1G1",1.37059040089728,0.737548910269571,TRUE
+"H460","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.46817,-1.49,0.07,8748,0.441,"GCNT3",1.15490195998574,0.355561410532161,FALSE
+"H460","Input","KEGG_P53_SIGNALING_PATHWAY",-0.31637,-1.02,0.4,7624,0.552,"RRM2, CHEK1, THBS1, CDK1, APAF1, TSC2, CD82, CDK2, CCNB1",0.397940008672038,0.258060922270801,FALSE
+"H460","Input","KEGG_PANCREATIC_CANCER",-0.32008,-1.04,0.374,7011,0.553,"CDK4, MAP2K1, PIK3CA, BRCA2, PIK3CB, AKT1, IKBKB, CDC42, MAPK1, PIK3R2, RAF1, RELA, MAPK3, RAC2, STAT1, AKT2, STAT3, TGFA",0.42712839779952,0.257274868695302,FALSE
+"H460","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41762,-1.33,0.132,7826,0.43,"DPYD, COASY, PANK4",0.87942606879415,0.366531544420413,FALSE
+"H460","Input","KEGG_PARKINSONS_DISEASE",0.5456,1.74,0.0357,2579,0.183,"UCHL1, ATP5PF, NDUFS6, ATP5PD, UQCRH, ATP5F1D, NDUFA2, NDUFS8, SNCA, NDUFA8, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, NDUFA7, COX5B, COX6B1, VDAC1, COX6A1, UBE2G2, HTRA2, NDUFS1, UQCRC1, NDUFA5, NDUFA3, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, NDUFB8, ATP5F1E, ATP5PB, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, NDUFV1, ATP5MC2, UQCR10, SLC25A6, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, VDAC2, ATP5F1A, ATP5PO, NDUFB6, NDUFA4L2, SLC25A31",1.44733178388781,0.737548910269571,TRUE
+"H460","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.43898,-1.39,0.132,5720,0.458,"YWHAQ, TUBA3C, FYN, TUBB4B, NCK1, TUBB6, CTNNB1, ARPC1B, ABL1, HCLS1, EZR, ARPC1A, ROCK1, RHOA, ROCK2, TUBA1B, ARPC4, TUBB3, TUBB1, YWHAZ, CDH1, ARPC3, CDC42, TUBB, ARPC2, TUBB2A, WASL, CTTN, TUBA1C",0.87942606879415,0.339134521996131,FALSE
+"H460","Input","KEGG_PATHWAYS_IN_CANCER",-0.23294,-0.767,0.768,6941,0.837,"LAMB3, GSTP1, MAP2K2, CDK4, CUL2, RXRB, MAP2K1, CKS1B, RHOA, RXRG, PIK3CA, STK36, BRCA2, HGF, SOS1, PTK2, TFG, PIK3CB, AKT1, GSK3B, PIAS4, ARNT, CDH1, TRAF6, IKBKB, MECOM, CDC42, DVL3, HSP90AA1, PLCG2, TCF7L2, MAPK1, DAPK1, PLCG1, RARA, LAMA3, LAMA4, PIK3R2, FGFR2, RAF1, RELA, STAT5A, MAPK3, TRAF3, RAC2, STAT1, NCOA4, HSP90AB1, AKT2, STAT5B, CDK2, STAT3, PIAS2, TGFA",0.114638779968488,0.07727454200674,FALSE
+"H460","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.28819,-0.925,0.512,6725,0.637,"RPE, UGP2, XYLB, CRYL1",0.290730039024169,0.19586056766465,FALSE
+"H460","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.52521,-1.72,0.0285,6028,0.77,"RBKS, ALDOC, PFKP, RPE, PRPS2, PGLS, PFKM, RPIA, PGM2, GPI, DERA, PGM1, PFKL, FBP1",1.54515513999149,0.113509274827518,FALSE
+"H460","Input","KEGG_PEROXISOME",-0.21418,-0.706,0.855,7303,0.856,"EHHADH, CAT, CRAT, IDH2, PEX6, MVK, FAR1, DAO, FAR2",0.0680338852718274,0.0675262353228468,FALSE
+"H460","Input","KEGG_PHENYLALANINE_METABOLISM",0.27242,0.871,0.586,1755,0.749,"ALDH3A1, GOT2, MAOA",0.232102383981909,0.125518182300534,FALSE
+"H460","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.34129,-1.1,0.311,6587,0.505,"INPP4B, PIP4K2A, PIP5K1A, CDS2, PLCB3, PIK3CA, OCRL, PIK3CB, IMPA1, INPPL1, PLCG2, PLCG1, INPP1, PIK3R2, DGKA, INPP5B, PIK3C2B, SYNJ2, DGKH",0.507239610973163,0.296708621881339,FALSE
+"H460","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.38312,1.24,0.215,2696,0.463,"HMOX1, ALAS1, FECH, HMOX2, HCCS, PPOX, GUSB, UGT2B17, EARS2, FTH1",0.667561540084395,0.334419008982047,FALSE
+"H460","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2417,-0.777,0.733,7109,0.829,"RXRB, DBI, CYP27A1, RXRG, EHHADH, CD36, FABP2, HMGCS2, FABP3",0.134896025358872,0.0814454694497265,FALSE
+"H460","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45982,1.48,0.0776,129,0.338,"AKR1D1",1.11013827874181,0.471083299722345,FALSE
+"H460","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.46106,-1.47,0.103,6546,0.432,"TAP2, UNG, ADA, DCLRE1C, PTPRC",0.987162775294828,0.364516253185088,FALSE
+"H460","Input","KEGG_PRION_DISEASES",0.54598,1.75,0.0458,689,0.209,"NCAM2, NCAM1, LAMC1, C9, HSPA5, NOTCH1",1.33913452199613,0.679853713888946,TRUE
+"H460","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.3699,-1.2,0.211,7138,0.44,"RPS6KA1, MAP2K1, PIK3CA, PIK3CB, AKT1, FZR1, CDC23, HSP90AA1, MAPK1, CDC16, MAPK14, PIK3R2, RAF1, CDK1, MAPK3, HSP90AB1, CCNA2, AKT2, CDK2, CCNB1, MAPK13, MAPK12",0.675717544702307,0.356547323513813,FALSE
+"H460","Input","KEGG_PROPANOATE_METABOLISM",0.27859,0.893,0.528,1587,0.749,"ACSS3, MCEE, ECHS1, SUCLG1, SUCLG2, ACAT1, PCCB",0.277366077466188,0.125518182300534,FALSE
+"H460","Input","KEGG_PROSTATE_CANCER",-0.44992,-1.44,0.1,6950,0.456,"GSTP1, MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, IKBKB, HSP90AA1, TCF7L2, MAPK1, PIK3R2, FGFR2, RAF1, RELA, MAPK3, HSP90AB1, CREB3L1, AKT2, CDK2, TGFA",1,0.341035157335565,FALSE
+"H460","Input","KEGG_PROTEASOME",0.15261,0.486,0.992,6839,0.996,"PSMB9, PSMB7, PSMA5, PSMC3, PSMB6, PSMA1, PSMC4, PSMA2, PSMB3, PSMC5, PSMD14, PSMB5, PSMC1, PSMA6, PSMC2, PSMC6, PSMA3, PSMB4, PSMD4, PSMA4, POMP, PSMD7, PSMA7, PSME3, PSMB2, PSMB10, PSMB8, PSMA8, PSMD8, PSMD13, PSMD11, PSMB1, PSMF1, PSMD6, PSMD2, PSMD12, PSMD1, PSME4, SEM1, PSME1, PSMD3",0.00348832784582135,0.00174066157630127,FALSE
+"H460","Input","KEGG_PROTEIN_EXPORT",0.23327,0.75,0.776,622,0.863,"HSPA5, SPCS1",0.110138278741812,0.0639892042847904,FALSE
+"H460","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.27386,-0.917,0.522,8202,0.643,"MDH1, GLUD2",0.282329496997738,0.191789027075778,FALSE
+"H460","Input","KEGG_PURINE_METABOLISM",0.28608,0.924,0.505,1909,0.748,"PAPSS2, PDE3B, PDE4D, PDE3A, POLR3H, NUDT9, POLR3K, POLR2H, POLR3D, GDA, POLR2C, NME4, POLR2L, POLR2D, POLR1E, AK2, NT5C, POLR2E, GUK1, POLR3GL, PRUNE1, POLR3G, POLR3C, ENPP1, POLD4, NME3, POLR2I, PFAS, PNPT1, POLR3F, POLR2F",0.296708621881339,0.126098402135539,FALSE
+"H460","Input","KEGG_PYRIMIDINE_METABOLISM",0.29286,0.956,0.456,1909,0.747,"POLR3H, POLR3K, POLR2H, POLR3D, TXNRD2, POLR2C, NME4, POLR2L, UPRT, TXNRD1, POLR2D, POLR1E, DUT, NT5C, POLR2E, TYMP, POLR3GL, POLR3G, POLR3C, POLD4, NME3, POLR2I, PNPT1, POLR3F, POLR2F",0.341035157335565,0.126679398184601,FALSE
+"H460","Input","KEGG_PYRUVATE_METABOLISM",-0.26043,-0.859,0.598,6912,0.723,"ACACA, ACYP1, ACSS2, GLO1, ACAT2, MDH1, PKLR, ACACB, PKM",0.223298816011589,0.140861702705469,FALSE
+"H460","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.38927,-1.24,0.207,6398,0.437,"KRAS, NRAS, ARPC1B, WASF2, CRKL, FGD3, PIP4K2A, CYFIP1, PIP5K1A, ITGA2, RAC1, SLC9A1, ARHGEF1, EZR, MAP2K2, IQGAP3, ARPC1A, ARHGEF7, PAK3, ROCK1, ITGB6, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PTK2, ROCK2, PAK4, PIK3CB, RDX, VCL, ARPC4, DIAPH3, MYH10, ARPC3, PXN, CFL1, ARHGEF12, CDC42, SCIN, ITGA4, ARPC2, MAPK1, BCAR1, NCKAP1, MYH14, PAK2, MYLK, PIK3R2, FGFR2, ARHGAP35, RAF1, ITGB3, MYH9, CSK, MAPK3, RAC2, VAV2, GSN, SSH3, DIAPH1, BAIAP2, WASL, CYFIP2",0.684029654543082,0.359518563029578,FALSE
+"H460","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.29623,-0.964,0.468,5747,0.599,"PRKAA1, GABARAPL2, PIK3C3, ATG12, PIK3R4, ATG7, ATG3, ATG4B",0.329754146925876,0.222573177610689,FALSE
+"H460","Input","KEGG_RENAL_CELL_CARCINOMA",-0.41953,-1.34,0.146,6398,0.469,"KRAS, NRAS, CRKL, RAC1, MAP2K2, PTPN11, PAK3, CUL2, MAP2K1, PIK3CA, PAK1, HGF, SOS1, PAK4, PIK3CB, AKT1, ARNT, GAB1, CDC42, MAPK1, PAK2, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.835647144215563,0.328827157284917,FALSE
+"H460","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.23037,-0.759,0.782,8024,0.833,"MME",0.106793246940152,0.0793549985932124,FALSE
+"H460","Input","KEGG_RETINOL_METABOLISM",-0.41015,-1.33,0.139,6676,0.43,"DHRS3, RDH11, ADH5, DGAT1, RDH10, ADH1C, DHRS9",0.856985199745905,0.366531544420413,FALSE
+"H460","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.46756,-1.52,0.0772,8118,0.419,"ACP5, TYR",1.11238269966426,0.377785977033705,FALSE
+"H460","Input","KEGG_RIBOSOME",-0.54356,-1.74,0.0351,6007,0.887,"RPL36, RPL27, RPL31, RPS26, RPL18, RPL11, RPS7, RPL3, RPS3, RPS13, RPS5, RPS9, RPL23, RPL10, RPL15, RPL26, RPL37A, RPL32, RPL18A, RPL10A, RPL7, RPS18, RPL14, RPL21, RPS15A, RPL35, RPS4X, RPS19, RPL8, RPS6, RPS2, RPL37, RPL9, RPL30, RPS24, RPS16, RPS25, RPL13A, RPL17, RPL28, RPL29, RPL19, RPL23A, RPL34, RPL27A, RPL24, RSL24D1, RPL22, RPL7A, FAU, RPS11, RPL36A, RPL36AL, RPS27L, UBA52, RPS23, RPS10, RPL38",1.45469288353418,0.0520763801682736,FALSE
+"H460","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.49258,-1.59,0.0621,7571,0.391,"TRAF6, IKBKB, RIPK1, MAPK14, RELA, TRAF3, IFIH1, MAPK13, ISG15, MAPK12, MAP3K1, CYLD",1.20690839982342,0.407823242604133,FALSE
+"H460","Input","KEGG_RNA_DEGRADATION",0.35517,1.16,0.268,2342,0.526,"HSPA9, HSPD1, EXOSC8, LSM4, DCP2, TENT4A, EXOSC1, LSM2, EXOSC4, EXOSC10, LSM8, EXOSC6, MPHOSPH6, DCPS, LSM3, EXOSC5, DCP1A, PNPT1, PARN, EXOSC7, WDR61, EXOSC9, CNOT2, LSM6",0.571865205971211,0.279014255846261,FALSE
+"H460","Input","KEGG_RNA_POLYMERASE",0.6689,2.11,0.00832,2035,0.123,"POLR3H, POLR3K, POLR2H, POLR3D, POLR2C, POLR2L, POLR2D, POLR1E, POLR2E, POLR3GL, POLR3G, POLR3C, POLR2I, POLR3F, POLR2F, POLR2G",2.07987667370928,0.910094888560602,TRUE
+"H460","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.33732,1.09,0.312,116,0.617,"PAPSS2, GGT1",0.505845405981557,0.209714835966758,FALSE
+"H460","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.2783,0.896,0.553,398,0.758,"FN1, LAMB1, PIK3R3, LAMA1, LAMC1, LAMA5, ITGAV, LAMB2",0.257274868695302,0.120330794367946,FALSE
+"H460","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.2615,-0.84,0.643,8342,0.75,"VAMP8, YKT6, VAMP3",0.191789027075778,0.1249387366083,FALSE
+"H460","Input","KEGG_SPHINGOLIPID_METABOLISM",0.60432,1.92,0.014,383,0.194,"GALC, PLPP3, GLA, ASAH1, ARSA",1.85387196432176,0.712198270069774,TRUE
+"H460","Input","KEGG_SPLICEOSOME",0.29516,0.968,0.447,2731,0.739,"PPIE, SNRPB2, SF3B4, LSM4, SRSF1, SNU13, LSM2, SNRPD3, SNRPF, HNRNPU, SRSF8, PHF5A, TRA2A, SNRPG, SF3B5, SRSF6, SRSF7, LSM8, SRSF5, PRPF18, SRSF9, PPIH, TXNL4A, RBM8A, SRSF3, LSM3, HNRNPA3, TCERG1, SRSF2, SRSF10, ISY1, NCBP2, TRA2B, RBM25, SF3A3, HNRNPK, RBMX, SNRPA, U2SURP, DDX5, SF3A1, SRSF4, LSM6, BCAS2, PRPF40A, ALYREF, SNRPB, PRPF4, RBM17, DHX8, CHERP, SNRNP70, SNRNP40, THOC3, DDX46",0.349692476868064,0.131355561605174,FALSE
+"H460","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.39267,-1.26,0.193,7080,0.44,"GYS1, PGM2, UGP2, MGAM, GPI, HK1, AGL, PGM2L1, PGM1",0.714442690992226,0.356547323513813,FALSE
+"H460","Input","KEGG_STEROID_BIOSYNTHESIS",-0.62399,-1.92,0.0214,6129,0.82,"CEL, LIPA, CYP51A1, LSS, NSDHL, SQLE, MSMO1, HSD17B7, SOAT2, FDFT1, DHCR24, TM7SF2, DHCR7",1.66958622665081,0.0861861476162833,FALSE
+"H460","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.69483,2.23,0.00204,285,0.0837,"CYP21A2, AKR1D1, CYP1B1, AKR1C3, AKR1C1",2.6903698325741,1.07727454200674,TRUE
+"H460","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.3127,0.996,0.423,1265,0.699,"C9, SNRPD3, C7",0.373659632624958,0.155522824254319,FALSE
+"H460","Input","KEGG_TASTE_TRANSDUCTION",0.53334,1.7,0.0334,2207,0.196,"CACNA1A, GNB1, GNB3, GNAS",1.47625353318844,0.707743928643524,TRUE
+"H460","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.66274,-2.11,0.00977,7922,0.672,"ACAT2, MVD, HMGCS2, MVK, FDPS, HMGCS1",2.01010543628123,0.172630726946175,FALSE
+"H460","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28637,0.904,0.53,536,0.757,"FST, TGFB2, TGFBR1, E2F5, THBS3, SMAD2",0.275724130399211,0.120904120499927,FALSE
+"H460","Input","KEGG_THYROID_CANCER",-0.50513,-1.65,0.0461,6376,0.36,"CTNNB1, KRAS, NRAS, MAP2K2, RXRB, MAP2K1, RXRG, TFG, CDH1, TCF7L2, MAPK1, MAPK3, NCOA4",1.33629907461035,0.443697499232713,FALSE
+"H460","Input","KEGG_TIGHT_JUNCTION",-0.27612,-0.884,0.588,5842,0.695,"TJP3, PPP2R2B, CSNK2A1, CSNK2A2, PPP2R2A, MYL12A, PPP2CB, GNAI3, AKT3, PARD6G, MAP3K20, LLGL2, CTNNB1, KRAS, NRAS, RAB13, PPP2R1A, PPP2CA, HCLS1, CDK4, EPB41, RHOA, TJAP1, AKT1, MYH10, PRKCQ, CDC42, F11R, MYH14, MYH7B, CLDN7, MYH3, MYH9, CGN, PRKCD, AKT2, PRKCI, CTTN, MYH11, EPB41L1, CLDN3, CRB3, CLDN18",0.230622673923862,0.158015195409886,FALSE
+"H460","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.36332,-1.17,0.23,6925,0.466,"TBK1, MAP2K2, MAP2K1, PIK3CA, IRF3, PIK3CB, AKT1, TAB2, IRAK4, TRAF6, IKBKB, RIPK1, MAPK1, MAPK14, PIK3R2, RELA, MAPK3, TRAF3, STAT1, AKT2, MAPK13, MAP2K4, MAPK12",0.638272163982407,0.33161408331,FALSE
+"H460","Input","KEGG_TRYPTOPHAN_METABOLISM",0.25244,0.812,0.697,789,0.792,"CYP1B1, KYNU, ECHS1",0.156767221901991,0.101274818410506,FALSE
+"H460","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.40881,-1.3,0.154,7221,0.438,"PIK3CA, PIK3CB, HK1, IKBKB, MAPK1, PIK3R2, MAPK3, PKLR, PRKCD, PKM, IRS1",0.812479279163537,0.3585258894959,FALSE
+"H460","Input","KEGG_TYROSINE_METABOLISM",-0.52107,-1.68,0.0581,6759,0.448,"COMT, MIF, GOT1, ADH5, TYRP1, ADH1C, TRMT11, METTL2B, LCMT1, ALDH1A3, DCT, TYR",1.23582386760967,0.348721986001856,FALSE
+"H460","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52938,-1.7,0.03,6979,0.463,"MAP2K2, CDK4, PAK3, NFATC3, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PAK4, PIK3CB, AKT1, GSK3B, PRKCQ, IKBKB, CDC42, PPP3CA, NFAT5, MAPK1, PLCG1, PAK2, MAPK14, PIK3R2, RAF1, RELA, MAPK3, VAV2, PPP3CB, AKT2, PTPRC, MAPK13, PTPN6, MAPK12, NFATC2",1.52287874528034,0.334419008982047,FALSE
+"H460","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.30709,-1,0.401,5542,0.57,"FBXO4, CUL4B, HERC2, HUWE1, FBXO2, UBE2D4, HERC4, SMURF1, CBL, UBE2N, CDC34, UBE2NL, UBE2K, UBA2, ANAPC4, UBA1, UBE2Q1, TRIM32, CBLB, UBE2L3, UBE4B, UBE2D2, NEDD4L, CUL3, CUL5, CUL1, DET1, UBE2O, CUL2, ITCH, CUL4A, UBE2E1, UBA6, SYVN1, PIAS4, FZR1, TRAF6, UBE2E2, WWP1, CDC23, TRIM37, CDC16, BTRC, KEAP1, SMURF2, UBE2C, UBE2L6, MAP3K1, PIAS2",0.396855627379818,0.244125144327509,FALSE
+"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.31571,1.01,0.384,1137,0.687,"PDHB, PDHA1",0.415668775632469,0.16304326294045,FALSE
+"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.38241,1.23,0.202,1863,0.462,"ACAA2, HSD17B10, MCEE, HIBADH, ACADSB, ECHS1, OXCT1, ACADS, IVD, ACAT1, BCKDHB, PCCB, AUH, BCKDHA, DLD",0.694648630553376,0.335358024443874,FALSE
+"H460","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.28505,-0.928,0.492,6712,0.639,"PRKACB, PLCB3, ARHGEF1, MAP2K2, ROCK1, MAP2K1, RHOA, ROCK2, PRKCQ, ARHGEF12, MAPK1, MYLK, RAF1, MAPK3, PRKCD, MYH11",0.30803489723264,0.1944991418416,FALSE
+"H460","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.42696,-1.35,0.121,5663,0.469,"ARHGDIA, RAB5B, NSF, DCTN1, DYNC1LI2, RAB5A, DYNLL1, PRKACB, DYNC1LI1, RAB11A, VAMP2, DYNLL2, ARHGDIB, DYNC1H1, RAB5C, DYNC2H1, CREB3L1",0.91721462968355,0.328827157284917,FALSE
+"H460","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.5541,-1.79,0.0238,6979,0.96,"MAP2K2, NFATC3, MAP2K1, PIK3CA, PTK2, PIK3CB, AKT1, MAPKAPK2, PXN, CDC42, PPP3CA, NFAT5, PLCG2, MAPK1, PLCG1, MAPK14, PIK3R2, RAF1, MAPK3, RAC2, HSPB1, PPP3CB, AKT2, MAPK13, MAPK12, NFATC2",1.62342304294349,0.0177287669604316,FALSE
+"H460","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.22788,0.739,0.789,2778,0.853,"TJP1, TCIRG1, PRKCB, ATP6V1F, SLC12A2, PDIA4, ACTG1, ATP6AP1, GNAS, ATP6V1E1, ACTB, ATP6V0C, ATP6V1G1, ATP6V1B2, ADCY9",0.10292299679058,0.069050968832477,FALSE
+"H460","Input","KEGG_VIRAL_MYOCARDITIS",-0.3596,-1.18,0.246,6642,0.461,"ICAM1, RAC1, ABL1, EIF4G2, MYH10, EIF4G1, MYH14, MYH7B, MYH3, MYH9, RAC2, MYH11, ABL2",0.609064892896621,0.336299074610352,FALSE
+"H460","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.26673,-0.87,0.615,5901,0.71,"CSNK2A1, CSNK2A2, MAP3K7, SMAD3, PPP2CB, CACYBP, FZD7, CSNK1E, CTNNB1, PPP2R1A, PPP2CA, PRKACB, RAC1, PLCB3, DAAM1, CUL1, ROCK1, NFATC3, RHOA, ROCK2, PPP2R5C, GSK3B, DVL3, PPP3CA, NFAT5, TCF7L2, PPP2R5B, BTRC, CSNK1A1, NLK, PPP2R5A, PPP2R5E, RAC2, PPP3CB, PPP2R5D, NFATC2",0.211124884224583,0.148741651280925,FALSE
+"H520","Input","KEGG_ABC_TRANSPORTERS",-0.288,-0.879,0.554,6792,0.679,"ABCA2, ABCD1, ABCC3, ABCA12, ABCG2, ABCA1, ABCB8",0.25649023527157,0.168130225719498,FALSE
+"H520","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.3015,-0.919,0.53,5328,0.652,"ARAF, RELA, AKT3, STAT3, GRB2, BRAF, STAT5A, PIK3CB, NFKB1, AKT1, PIK3R1, PML, CHUK, MAPK3, MAPK1, PIK3R3, IKBKG, SOS1, CCND1, IKBKB",0.275724130399211,0.18575240426808,FALSE
+"H520","Input","KEGG_ADHERENS_JUNCTION",-0.43395,-1.29,0.165,6625,0.433,"WAS, MAPK3, NECTIN4, RHOA, MAPK1, ACTN2, PARD3, MET, ERBB2, ACTN1, CDH1, MAP3K7, EGFR, NECTIN2, RAC3, VCL, BAIAP2, PTPRJ, TGFBR2, IQGAP1, IGF1R, RAC2",0.782516055786094,0.363512103646635,FALSE
+"H520","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.38133,-1.13,0.273,5343,0.458,"PRKAB1, RELA, AKT3, PRKAB2, STAT3, NFKB1, NFKBIB, AKT1, TRAF2, CHUK, TRADD, IRS2, IKBKG, ACSL4, IRS1, IKBKB, PRKCQ, RXRG",0.563837352959244,0.339134521996131,FALSE
+"H520","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.37669,1.18,0.216,282,0.438,"GLUD2, ASS1, GPT2, GOT2",0.665546248849069,0.3585258894959,FALSE
+"H520","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.42171,-1.26,0.162,6303,0.414,"PIK3R1, PRKCA, MAPK3, MAPK1, IRS2, PIK3R3, SLC9A3R2, NEDD4L, PRKCB, IRS1, PRKCG",0.790484985457369,0.382999658879101,FALSE
+"H520","Input","KEGG_ALZHEIMERS_DISEASE",0.32205,1.01,0.379,2586,0.57,"MME, ITPR1, SDHD, ATP5MC2, NDUFA6, ATP5F1C, GRIN1, NDUFS7, ERN1, UQCRH, BAD, CASP7, ATP5PO, PSEN2, ATP5PB, ADAM10, ATP5F1B, ATP5F1E, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, NDUFA4, NDUFB7, HSD17B10, SDHC, NDUFB4, NDUFS8, NDUFS6, GSK3B, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP5PD, NDUFA10, CALML3, NDUFB8, NDUFV1, SDHB, NDUFS4, NDUFS3, COX4I1, ATF6, NDUFAB1, NDUFS1, PSEN1, ATP2A2, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, UQCRQ, SNCA, NCSTN",0.421360790031928,0.244125144327509,FALSE
+"H520","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.61161,1.91,0.025,1050,0.282,"WARS2, RARS2, EARS2, CARS2, LARS2, NARS2, MTFMT",1.60205999132796,0.549750891680639,FALSE
+"H520","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.41469,-1.23,0.186,6115,0.43,"UGP2, AMDHD2, HEXB, GNPNAT1, GFPT2, CMAS, GMPPB, GMPPA, NAGK, GFPT1, GALK1, UAP1, UGDH, NPL, PGM1, GALE",0.730487055782084,0.366531544420413,FALSE
+"H520","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.24265,0.787,0.718,982,0.809,"MAP2K6, SOD1, NEFL, GRIN1, DERL1, BAD, BCL2L1",0.1438755557577,0.0920514783877277,FALSE
+"H520","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.52673,-1.58,0.0611,6404,0.442,"TAP2, HSP90AB1, TAPBP, CALR, HSPA6, HSP90AA1, PSME3, CTSL, CD74, LGMN, B2M, CTSB, HSPA2, HSPA1L, CTSS",1.21395878975745,0.354577730650908,FALSE
+"H520","Input","KEGG_APOPTOSIS",-0.45471,-1.35,0.12,5725,0.4,"DFFB, PIK3CB, PRKAR2B, PPP3CB, NFKB1, PPP3CA, IRAK4, RIPK1, AKT1, PIK3R1, PRKACA, DFFA, TRAF2, CASP8, FADD, MYD88, CHUK, CASP6, TRADD, IL1RAP, BIRC2, PIK3R3, FAS, IKBKG, BID, ENDOD1, APAF1, CAPN1, TP53, CAPN2, PPP3R1, IKBKB, TNFRSF10D",0.920818753952375,0.397940008672038,FALSE
+"H520","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.52063,-1.55,0.0797,7424,0.356,"PLA2G4A, CBR3, ALOX5, GGT1, EPHX2, PTGS2, PTGES",1.09854167860389,0.448550002027125,FALSE
+"H520","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.43402,1.37,0.135,539,0.297,"MAOB, ALDH2, GLUD2, ASS1, GATM, MAOA, GOT2, ALDH3A2, PYCR1, SMS, CKB",0.869666231504994,0.527243550682788,FALSE
+"H520","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.41071,-1.21,0.233,6698,0.427,"ITGB3, ACTN2, ACTN1, ITGB5, ITGA2B, DES, ITGB1, ITGAV, ITGA1, LMNA, GJA1, ITGA3, ITGA5, ITGB6",0.632644078973981,0.369572124974976,FALSE
+"H520","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.60321,1.86,0.0442,1756,0.191,"ALDH2, ALDH3A2, ALDH7A1, ALDH9A1, ALDH1B1",1.35457773065091,0.718966632752272,TRUE
+"H520","Input","KEGG_AXON_GUIDANCE",-0.47552,-1.43,0.114,6559,0.373,"ROCK2, ABLIM1, MAPK3, ABL1, SRGAP1, RHOA, MAPK1, LIMK1, MET, ROCK1, SEMA4B, EPHA6, NRP1, ABLIM3, SRGAP2, SRGAP3, SLIT2, PLXNB2, EFNB2, CFL2, ITGB1, RAC3, EFNA5, L1CAM, EPHA2, PPP3R1, EFNB1, EPHB2, EFNA1, RAC2, NTN4, SEMA3C",0.943095148663527,0.428291168191312,FALSE
+"H520","Input","KEGG_BASAL_CELL_CARCINOMA",0.48127,1.52,0.0965,1560,0.275,"FZD1, CTNNB1, TCF7L1, TCF7L2, GSK3B",1.01547268665621,0.560667306169737,FALSE
+"H520","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.27489,0.851,0.633,6007,0.717,"TBPL1, GTF2H3, GTF2H4, GTF2H2, TAF9B, TAF2, TAF6L, GTF2H1, TAF12, GTF2A2, GTF2F1, GTF2I, TAF1, TAF5L, GTF2B, GTF2IRD1, TAF9, TBP, GTF2F2, TAF4, TAF7, TAF6, GTF2E2, TAF5, GTF2A1, TAF10, GTF2E1",0.198596289982645,0.1444808443322,FALSE
+"H520","Input","KEGG_BASE_EXCISION_REPAIR",-0.29101,-0.866,0.618,6072,0.688,"HMGB1, XRCC1, POLD1, POLD4, POLE3, POLE2, LIG1, POLE, PCNA, PARP4",0.209011524911184,0.162411561764489,FALSE
+"H520","Input","KEGG_BETA_ALANINE_METABOLISM",0.48146,1.49,0.101,2076,0.249,"ALDH2, HIBCH, ALDH3A2, MLYCD, SMS, ALDH7A1, ALDH9A1, ALDH1B1, HADHA, ECHS1",0.995678626217357,0.603800652904264,FALSE
+"H520","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.40583,1.27,0.169,651,0.363,"FADS2, PECR, HSD17B12, HACD2, FADS1",0.772113295386326,0.440093374963888,FALSE
+"H520","Input","KEGG_BLADDER_CANCER",-0.58201,-1.72,0.0397,6638,0.519,"TYMP, MAPK3, MAPK1, ERBB2, DAPK1, CDK4, CDH1, CCND1, EGFR, TP53, DAPK3, RPS6KA5, CDKN2A",1.40120949323689,0.284832642151542,FALSE
+"H520","Input","KEGG_BUTANOATE_METABOLISM",0.29553,0.93,0.457,2076,0.642,"ALDH2, ALDH3A2, BDH1, ALDH5A1, ALDH7A1, ALDH9A1, ALDH1B1, OXCT1, HADH, HADHA, PDHA1, L2HGDH, ECHS1",0.34008379993015,0.192464971931147,FALSE
+"H520","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.45009,-1.34,0.13,5683,0.404,"GRB2, PTPN6, PIK3CB, PPP3CB, NFKB1, PPP3CA, NFKBIB, AKT1, PIK3R1, NFATC2, BCL10, CHUK, MAPK3, MAPK1, CD22, PIK3R3, IKBKG, SOS1, PRKCB, VAV2, RAC3, PPP3R1, PLCG2, IKBKB, PIK3AP1, CARD11, RAC2",0.886056647693163,0.393618634889395,FALSE
+"H520","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.32157,-0.96,0.481,6959,0.601,"ERBB2, PLCB3, ATP2A3, ATP2B2, ATP2B4, PLCD3, EGFR, PRKCB, ERBB4, CACNA1A, PPP3R1, PLCG2, TNNC1, ITPR3, ITPKA, ADCY9, PRKCG, ERBB3",0.317854923626168,0.22112552799726,FALSE
+"H520","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.2214,-0.672,0.891,7023,0.902,"TPM1, TPM2, TPM3, TNNC1, TPM4, MYL3",0.0501222959631252,0.0447934624580583,FALSE
+"H520","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.37417,-1.13,0.283,6875,0.458,"CD40, CD22, CDH15, CDH3, CLDN11, ICAM2, CDH1, CD58, ITGB1, NECTIN2, L1CAM, ITGAV, CDH5, CLDN4, ICAM1, ITGB2, CD274, SDC4, CLDN6, CD99",0.54821356447571,0.339134521996131,FALSE
+"H520","Input","KEGG_CELL_CYCLE",-0.28827,-0.857,0.622,6390,0.697,"MCM4, TTK, MCM7, MCM3, YWHAZ, ABL1, PLK1, CHEK2, CDC45, MCM6, CCNA2, YWHAE, YWHAQ, CDK4, YWHAG, FZR1, YWHAH, YWHAB, PCNA, CCND1, TP53, CCNB1, TGFB1, CDKN2A",0.206209615309181,0.156767221901991,FALSE
+"H520","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.34986,-1.07,0.32,5640,0.505,"STAT3, PLCB4, GRB2, BRAF, GNB2, PREX1, PIK3CB, CRK, CCL13, NFKB1, NFKBIB, AKT1, PIK3R1, PRKACA, GRK2, STAT2, DOCK2, WASL, BCAR1, ROCK2, WAS, CHUK, MAPK3, GNG4, RHOA, MAPK1, PARD3, SHC1, ROCK1, PLCB3, ARRB2, PIK3R3, IKBKG, SOS1, STAT1, PXN, CXCL5, CRKL, PRKCB, VAV2, PRKCD, IKBKB, ADCY9, GNG12, ARRB1, RAC2",0.494850021680094,0.296708621881339,FALSE
+"H520","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.3625,-1.08,0.339,5683,0.496,"GRB2, BRAF, STAT5A, CTBP2, PIK3CB, CRK, NFKB1, AKT1, PIK3R1, BCR, CHUK, MAPK3, ABL1, MAPK1, SHC1, PIK3R3, IKBKG, SOS1, CDK4, CCND1, CRKL, TP53, TGFB1, TGFBR2, IKBKB, CDKN2A",0.469800301796918,0.304518323509803,FALSE
+"H520","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29783,0.938,0.495,2927,0.642,"SDHD, SUCLA2, PCK2, SDHC, PDHA1, CS, SDHB, DLAT, IDH3B, SUCLG1, IDH3G, PDHB, SDHA, IDH1, IDH3A",0.305394801066431,0.192464971931147,FALSE
+"H520","Input","KEGG_COLORECTAL_CANCER",-0.29811,-0.912,0.502,6266,0.65,"AKT1, PIK3R1, MSH2, MAPK3, MLH1, RHOA, MAPK1, BIRC5, PIK3R3, CCND1, TP53, RAC3, TGFB1, TGFBR2, RAC2",0.299296282854981,0.187086643357144,FALSE
+"H520","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.44316,-1.32,0.159,7300,0.412,"PLG, MBL2, F8, CD59, C3, CD55, A2M, PLAU, CFB, SERPINE1, CFI, SERPINA1, TFPI",0.798602875679548,0.385102783966865,FALSE
+"H520","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.22395,0.701,0.86,1687,0.896,"GOT2, DNMT3B, SMS, DNMT3A, CBS, MAT1A, APIP, MAT2A",0.0655015487564323,0.0476919903378748,FALSE
+"H520","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.37407,-1.11,0.31,6842,0.479,"MET, CD40, IL1RAP, TNFRSF21, FAS, IFNGR1, HGF, ACVR1, CXCL5, EGFR, IL6ST, TGFB1, TGFBR2, IL6, EPO, OSMR, LTBR, IL18, TNFRSF10D",0.508638306165727,0.319664486585437,FALSE
+"H520","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.53277,-1.59,0.0623,5897,0.455,"TBK1, NFKB1, NFKBIB, TREX1, RIPK1, CHUK, IKBKG, DDX58, IRF3, IKBKB, IL6, ZBP1, IL18",1.20551195334083,0.341988603342888,FALSE
+"H520","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.53114,-1.61,0.0585,7023,0.488,"TPM1, TPM2, ITGB5, ITGA2B, DES, ITGB1, TPM3, TGFB1, ITGAV, ITGA1, LMNA, TNNC1, TPM4, MYL3, ADCY9, ITGA3, ITGA5, ITGB6",1.23284413391782,0.311580177997289,FALSE
+"H520","Input","KEGG_DNA_REPLICATION",-0.53333,-1.59,0.0598,4986,0.455,"POLA1, RFC5, RNASEH1, POLD2, RFC2, RFC4, POLD3, MCM5, POLA2, RPA3, PRIM1, POLD1, MCM4, MCM7, MCM3, PRIM2, POLD4, POLE3, RNASEH2A, RNASEH2C, POLE2, MCM6, LIG1, POLE, PCNA",1.22329881601159,0.341988603342888,FALSE
+"H520","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.6349,-1.92,0.0167,6679,0.351,"MAPK3, MAPK1, NOTCH2, SOS1, EGFR, NOTCH3, ETV6, ETS1, ETS2",1.77728352885242,0.454692883534176,FALSE
+"H520","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.57053,1.84,0.0247,204,0.183,"MAOB, ALDH3A1, GSTA4, GSTM2, GSTA5, MAOA",1.60730304674033,0.737548910269571,TRUE
+"H520","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.48686,-1.49,0.0766,7911,0.373,"DPYD, UPP1, TPMT, CDA",1.1157712303674,0.428291168191312,FALSE
+"H520","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.4673,-1.38,0.131,6996,0.381,"HMMR, ITGB5, COL4A1, ITGA2B, ITGB1, LAMA3, LAMA4, COL6A1, ITGAV, ITGA1, LAMB3, TNC, LAMB1, COL5A2, ITGA3, SDC4, ITGA5, ITGB6",0.882728704344236,0.419075024324381,FALSE
+"H520","Input","KEGG_ENDOCYTOSIS",-0.45783,-1.35,0.144,6062,0.4,"RUFY1, LDLR, STAM2, PLD2, SNF8, SMURF2, VPS36, GIT1, CHMP2A, CLTB, VPS37A, GRK2, PRKCI, SH3GLB1, CHMP4C, EHD3, RAB22A, ITCH, HGS, CHMP5, EPN3, HSPA6, PDCD6IP, ARFGAP1, ARFGAP3, RNF41, RAB11FIP4, STAM, PARD3, MET, SH3GLB2, CHMP4A, CHMP4B, ARRB2, RABEP1, DNAJC6, ARF6, EGFR, NEDD4L, ERBB4, EPS15, EPN1, DAB2, CLTA, EHD2, SH3KBP1, EHD1, PARD6B, RAB31, HSPA2, PARD6G, RAB11FIP5, ARRB1, IGF1R, ERBB3, HSPA1L",0.84163750790475,0.397940008672038,FALSE
+"H520","Input","KEGG_ENDOMETRIAL_CANCER",-0.34435,-1.01,0.391,5533,0.552,"AKT3, CTNNA1, GRB2, BRAF, PIK3CB, AKT1, PIK3R1, MAPK3, MLH1, MAPK1, ERBB2, ILK, PIK3R3, SOS1, CDH1, CCND1, EGFR, TP53",0.407823242604133,0.258060922270801,FALSE
+"H520","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.18133,0.566,0.96,1025,0.989,"PTPRZ1, JAM3, F11R, ATP6V0A1, ADAM10, ATP6V0A2",0.0177287669604316,0.0048037084028206,FALSE
+"H520","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.40815,-1.22,0.205,5277,0.421,"NCK2, ARAF, HBEGF, AKT3, PAK2, GRB2, BRAF, STAT5A, PIK3CB, CRK, PLCG1, ABL2, CAMK2D, AREG, AKT1, PIK3R1, PRKCA, MAPK3, ABL1, MAPK1, SHC1, ERBB2, PIK3R3, SOS1, EGFR, CRKL, PRKCB, ERBB4, PLCG2, PRKCG, ERBB3",0.688246138944246,0.375717904164332,FALSE
+"H520","Input","KEGG_ETHER_LIPID_METABOLISM",-0.34683,-1.04,0.365,5362,0.525,"PAFAH1B1, PLD1, PLA2G12A, LPCAT1, PAFAH1B2, PLD2, PAFAH1B3, PLPP3, PLA2G4A",0.437707135543525,0.279840696594043,FALSE
+"H520","Input","KEGG_FATTY_ACID_METABOLISM",0.46753,1.5,0.104,2076,0.253,"ACAA2, ALDH2, ECI1, ALDH3A2, ACSL5, ALDH7A1, ALDH9A1, ACOX1, CPT2, ECI2, ALDH1B1, CPT1C, HADH, HADHA, GCDH, CPT1A, ECHS1",0.98296666070122,0.596879478824182,FALSE
+"H520","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.31983,-0.954,0.484,6266,0.604,"AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, PIK3R3, SOS1, PLA2G4A, PRKCB, VAV2, RAC3, PLCG2, PRKCD, RAC2",0.315154638355588,0.218963061378868,FALSE
+"H520","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.4002,-1.19,0.222,5775,0.448,"PIK3CB, CRK, ARPC3, CFL1, ARPC2, PLCG1, PLD2, AKT1, PIK3R1, PRKCA, DOCK2, WASL, MARCKS, WAS, MAPK3, MAPK1, PLPP3, LIMK1, PIK3R3, ARPC1B, ARPC5, PLA2G4A, CFL2, ARF6, CRKL, PRKCB, GSN, VAV2, SCIN, PLCG2, PRKCD, VASP, PRKCG, RAC2, AMPH",0.653647025549361,0.348721986001856,FALSE
+"H520","Input","KEGG_FOCAL_ADHESION",-0.56261,-1.71,0.0475,6499,0.431,"BCAR1, FLT4, ROCK2, COL6A3, TLN1, MAPK3, ITGB3, DOCK1, RHOA, MAPK1, PARVB, ACTN2, MET, SHC1, ERBB2, ACTN1, ROCK1, ILK, BIRC2, PIK3R3, ARHGAP35, ITGB5, COL4A1, HGF, SOS1, CAV1, ITGA2B, PXN, CCND1, ITGB1, PPP1R12A, MYL12A, EGFR, CRKL, PRKCB, LAMA3, LAMA4, CAPN2, VAV2, RAC3, COL6A1, VCL, ITGAV, ITGA1, FLNA, LAMB3, TNC, PARVA, LAMB1, MYL9, COL5A2, FLNC, VASP, PRKCG, ITGA3, IGF1R, ZYX, CAV2, FLNB, ITGA5, RAC2, ITGB6",1.32330639037513,0.365522729839268,FALSE
+"H520","Input","KEGG_FOLATE_BIOSYNTHESIS",0.47477,1.51,0.0864,75,0.269,"GGH",1.06348625752111,0.570247719997592,FALSE
+"H520","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.35974,-1.09,0.319,5729,0.488,"ALDOC, AKR1B1, PMM1, PHPT1, TPI1, FBP2, MTMR1, PFKL, MTMR6, GMPPB, GMPPA, MTMR7, ALDOA, PFKFB2, PFKP",0.496209316942819,0.311580177997289,FALSE
+"H520","Input","KEGG_GALACTOSE_METABOLISM",-0.41829,-1.25,0.185,7354,0.419,"GALK1, B4GALT1, PGM1, GALE, PFKP",0.732828271596986,0.377785977033705,FALSE
+"H520","Input","KEGG_GAP_JUNCTION",-0.33642,-1,0.402,6679,0.561,"MAPK3, MAPK1, PLCB3, TUBB1, TUBB3, SOS1, EGFR, PRKCB, TUBB4B, GJA1, ITPR3, ADCY9, PRKCG, TUBA4A",0.39577394691553,0.251037138743839,FALSE
+"H520","Input","KEGG_GLIOMA",-0.51035,-1.5,0.0956,5683,0.376,"GRB2, BRAF, PIK3CB, PLCG1, CAMK2D, AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, SHC1, PIK3R3, SOS1, CDK4, CCND1, EGFR, PRKCB, TP53, PLCG2, CDKN2A, PRKCG, IGF1R",1.0195421077239,0.424812155072339,FALSE
+"H520","Input","KEGG_GLUTATHIONE_METABOLISM",0.315,1,0.415,725,0.573,"GSTA4, GSTM2, GSTA5, PGD, SMS, GCLC, GSTZ1",0.381951903287907,0.24184537803261,FALSE
+"H520","Input","KEGG_GLYCEROLIPID_METABOLISM",0.2907,0.912,0.472,1380,0.66,"ALDH2, AKR1A1, AGPAT4, GK, ALDH3A2, PLPP2, PLPP1, ALDH7A1, ALDH9A1, DGKE",0.326058001365912,0.180456064458131,FALSE
+"H520","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.30194,-0.899,0.54,5789,0.658,"PLA2G12A, ETNK1, LPCAT1, CDS2, DGKZ, PLD2, GPAT3, LPGAT1, LYPLA2, GPAT4, MBOAT7, CDS1, PLPP3, AGPAT3, GPD2, DGKH, PCYT2, AGPAT2, PLA2G4A, GPD1L, PEMT, DGKA",0.267606240177031,0.181774106386044,FALSE
+"H520","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.59227,1.9,0.0137,384,0.244,"PIPOX, MAOB, GLDC, GATM, MAOA, PHGDH, CHDH",1.86327943284359,0.612610173661271,TRUE
+"H520","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.26249,-0.772,0.736,6205,0.796,"TPI1, FBP2, GAPDH, PKLR, ENO1, PFKL, LDHA, DLD, PGAM1, PGAM4, ENO2, ALDOA, ALDH1A3, LDHB, PGM1, ACSS2, PFKP, GALM, ALDH3B1",0.133122185662501,0.0990869322623309,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.37979,-1.14,0.263,8200,0.47,"CHST12",0.580044251510242,0.327902142064283,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.59244,1.89,0.022,2580,0.218,"EXT2, B3GAT3, B4GALT7, HS2ST1, XYLT2, EXT1, EXTL3, HS3ST1",1.65757731917779,0.661543506395395,TRUE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.7729,-2.34,0,7363,0.078,"ST3GAL1, B4GAT1, B3GNT2, B4GALT1",Inf,1.10790539730952,TRUE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.18809,-0.564,0.966,5019,0.99,"HGSNAT, GLB1, HPSE, GALNS, GUSB, GNS, HEXB, IDS, SGSH",0.0150228735845067,0.00436480540245009,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.23468,0.726,0.795,2188,0.903,"B4GALNT1, SLC33A1, HEXA",0.0996328713435297,0.0443122496864942,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.64224,-1.95,0.0159,6425,0.377,"NAGA, HEXB, ST3GAL1, B3GALT5",1.79860287567955,0.423658649794207,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.82526,-2.46,0,7401,0.0589,"B3GNT3, B4GAT1, B3GNT2, FUT3, B4GALT1, B3GALT5",Inf,1.2298847052129,TRUE
+"H520","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.45217,1.43,0.0918,1925,0.266,"PIGX, PIGM, PIGA, PIGO, PGAP1, PIGQ",1.03715731879876,0.575118363368933,FALSE
+"H520","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.36436,1.17,0.24,1923,0.438,"MTHFD2, GRHPR, MTHFD1L, CS",0.619788758288394,0.3585258894959,FALSE
+"H520","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.28103,-0.833,0.638,6200,0.716,"PLD2, CAMK2D, PRKACA, PRKCA, MAPK3, MAPK1, PLCB3, SOS1, PLA2G4A, EGFR, PRKCB, MMP14, PRKCD, ITPR3, ADCY9",0.195179321278838,0.145086977692144,FALSE
+"H520","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.36966,-1.09,0.319,7659,0.488,"LRP2, CSNK1A1",0.496209316942819,0.311580177997289,FALSE
+"H520","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.4953,-1.5,0.0793,7231,0.376,"ITGA2B, CD59, CD55, CD9, ITGA1, ANPEP, IL6, CD33, ITGA3, EPO, ITGA5",1.1007268126824,0.424812155072339,FALSE
+"H520","Input","KEGG_HISTIDINE_METABOLISM",0.55534,1.77,0.0338,694,0.213,"MAOB, ALDH3A1, ALDH2, MAOA, ALDH3A2, TRMT11",1.47108329972235,0.671620396561262,TRUE
+"H520","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.16828,-0.511,0.997,6290,1,"RPA3, POLD1, BLM, POLD4, TOP3B",0.00130484168834428,0,FALSE
+"H520","Input","KEGG_HUNTINGTONS_DISEASE",0.32765,1.03,0.369,2479,0.552,"SLC25A4, ITPR1, SOD1, SDHD, ATP5MC2, NDUFA6, TFAM, ATP5F1C, GRIN1, NDUFS7, UQCRH, VDAC1, ATP5PO, ATP5PB, ATP5F1B, ATP5F1E, VDAC3, ATP5F1A, NDUFA9, CYC1, TBPL1, NDUFB3, CREB1, NDUFA7, NDUFA4, NDUFB7, SLC25A31, SDHC, NDUFB4, NDUFS8, POLR2A, SLC25A5, NDUFS6, NDUFS5, NDUFC2, UQCRC2, SIN3A, UQCRFS1, ATP5PD, NDUFA10, NDUFB8, SLC25A6, POLR2B, NDUFV1, POLR2H, VDAC2, SDHB, NDUFS4, NDUFS3, COX4I1, SOD2, NDUFAB1, NDUFS1, HDAC2, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, POLR2K, NDUFA3",0.43297363384094,0.258060922270801,FALSE
+"H520","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.56424,-1.71,0.0391,7023,0.431,"TPM1, TPM2, ITGB5, ITGA2B, DES, ITGB1, TPM3, TGFB1, ITGAV, ITGA1, LMNA, TNNC1, TPM4, IL6, MYL3, ACE, ITGA3, ITGA5, ITGB6",1.40782324260413,0.365522729839268,FALSE
+"H520","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42131,-1.28,0.166,6626,0.439,"PIP4K2C, SYNJ2, PLCB3, INPP1, PLCD3, PLCG2, ITPK1, IMPA2, ITPKA, INPP4B, ISYNA1",0.779891911959945,0.357535479757879,FALSE
+"H520","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.22647,-0.682,0.857,5533,0.906,"AKT3, PRKAB2, PPP1CA, GRB2, BRAF, PIK3CB, PRKAR2B, CRK, PTPN1, EXOC7, FBP2, AKT1, PIK3R1, PRKACA, PKLR, PRKCI, MAPK3, MAPK1, TSC1, SHC1, IRS2, PIK3R3, FASN, SOS1, RHEB, CRKL, PPP1R3D, PYGB, TRIP10, IRS1, IKBKB",0.0670191780768018,0.0428718023231869,FALSE
+"H520","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.74123,-2.2,0.00487,6875,0.13,"CD40, TGFB1, IL6, LTBR",2.31247103878537,0.886056647693163,TRUE
+"H520","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.4681,-1.4,0.106,5640,0.388,"STAT3, GRB2, STAT5A, PTPN6, PIK3CB, STAM2, IFNAR1, JAK1, AKT1, PIK3R1, STAT2, OSM, STAM, PIK3R3, IFNGR1, SOS1, STAT1, CCND1, IRF9, IL6ST, IL6, STAT6, EPO, OSMR",0.97469413473523,0.411168274405793,FALSE
+"H520","Input","KEGG_LEISHMANIA_INFECTION",-0.49863,-1.5,0.0831,5911,0.376,"NFKB1, NFKBIB, IRAK4, JAK1, TAB1, MYD88, MAPK3, MAPK1, CYBA, IFNGR1, STAT1, TAB2, ITGB1, C3, MAP3K7, PRKCB, TGFB1, PTGS2, ITGB2",1.08039897621589,0.424812155072339,FALSE
+"H520","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.54327,-1.63,0.0441,6788,0.492,"RHOA, ACTN2, ACTN1, ROCK1, CYBA, PIK3R3, ARHGAP35, CLDN11, PXN, ITGB1, MYL12A, PRKCB, VAV2, VCL, PLCG2, EZR, MYL9, CDH5, VASP, CLDN4, PRKCG, ICAM1, ITGB2, SIPA1, RAC2, CLDN6, CD99",1.35556141053216,0.30803489723264,FALSE
+"H520","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.68026,2.13,0.00822,2450,0.26,"ALDH2, ALDH3A2, ALDH7A1, ALDH9A1, ALDH1B1, HADHA, ECHS1, YOD1",2.08512818245995,0.585026652029182,FALSE
+"H520","Input","KEGG_LONG_TERM_DEPRESSION",-0.32741,-0.991,0.43,5660,0.556,"PLCB4, BRAF, PPP2CB, PLA2G12A, PPP2R1A, PRKCA, MAPK3, MAPK1, PLCB3, PLA2G4A, PRKCB, CACNA1A, ITPR3, PRKCG, IGF1R",0.366531544420413,0.254925208417942,FALSE
+"H520","Input","KEGG_LONG_TERM_POTENTIATION",-0.34625,-1.05,0.369,5643,0.523,"PPP1CA, PLCB4, BRAF, PPP3CB, PPP3CA, RPS6KA6, RPS6KA2, CAMK2D, PRKACA, PRKCA, MAPK3, MAPK1, PLCB3, PPP1R12A, PRKCB, RPS6KA1, PPP3R1, ITPR3, PRKCG",0.43297363384094,0.281498311132726,FALSE
+"H520","Input","KEGG_LYSINE_DEGRADATION",0.4799,1.54,0.0644,2201,0.271,"PIPOX, ALDH2, AASS, ALDH3A2, AADAT, NSD3, NSD2, NSD1, ALDH7A1, ALDH9A1, ALDH1B1, HADH, HADHA, GCDH, ECHS1, SETD1A, DOT1L",1.19111413264019,0.567030709125594,FALSE
+"H520","Input","KEGG_LYSOSOME",-0.27317,-0.799,0.708,5930,0.766,"AP3M2, CTSC, GNS, AP3M1, AP1S3, CTSZ, CLTB, NAGA, HEXB, GGA1, AP3B1, IDS, AP1S1, AP1B1, ABCA2, TPP1, FUCA1, M6PR, CTSL, NPC2, GGA3, LGMN, CTSA, PSAPL1, CTSV, SGSH, CLTA, TCIRG1, ATP6V0A4, CTSB, CTSS, CTSH, LAPTM4A",0.149966742310231,0.115771230367396,FALSE
+"H520","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.42418,-1.26,0.189,5634,0.414,"PAK2, RASA2, HSPA8, GRB2, BRAF, RPS6KA4, MAP3K5, HSPA1A, PLA2G12A, CRK, DUSP3, PPP3CB, NFKB1, PPP3CA, MAP3K20, RPS6KA6, PPM1B, RPS6KA2, MAPKAPK2, SRF, AKT1, PRKACA, PRKCA, NFATC2, TAB1, TRAF2, HSPA6, CHUK, MAPK3, PPM1A, NF1, MAPK1, ARRB2, FAS, IKBKG, SOS1, PLA2G4A, TAB2, MAP3K7, STMN1, EGFR, CRKL, PRKCB, TP53, CACNA1A, TAOK3, RAC3, RPS6KA1, TGFB1, MOS, PPP3R1, MAP3K11, FLNA, TGFBR2, IKBKB, FLNC, STK4, HSPA2, GNG12, RPS6KA5, HSPB1, PRKCG, ARRB1, RRAS, HSPA1L, FLNB, RAC2",0.723538195826756,0.382999658879101,FALSE
+"H520","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.2979,-0.901,0.539,6339,0.662,"PKLR, MNX1, IAPP",0.268411234813261,0.1791420105603,FALSE
+"H520","Input","KEGG_MELANOGENESIS",0.22826,0.713,0.819,1560,0.892,"KITLG, FZD1, CTNNB1, TCF7L1, GNAO1, PRKACB, CREB1, TCF7L2, ADCY6, MAP2K1, GSK3B",0.0867160982395816,0.0496351456238769,FALSE
+"H520","Input","KEGG_MELANOMA",-0.35006,-1.06,0.336,6679,0.514,"MAPK3, MAPK1, MET, PIK3R3, HGF, CDK4, CDH1, CCND1, EGFR, TP53, CDKN2A, IGF1R",0.473660722610156,0.289036881004724,FALSE
+"H520","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.59069,1.86,0.0339,182,0.191,"ALDH3A1, AKR1C2, AKR1C1, AKR1C3, GSTA4, GSTM2, GSTA5, EPHX1",1.46980030179692,0.718966632752272,TRUE
+"H520","Input","KEGG_MISMATCH_REPAIR",-0.51797,-1.55,0.0699,5079,0.356,"RFC5, POLD2, RFC2, RFC4, MSH6, POLD3, MSH3, RPA3, POLD1, MSH2, POLD4, MLH1, PMS2, LIG1, PCNA",1.15552282425432,0.448550002027125,FALSE
+"H520","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.44162,-1.32,0.149,5533,0.412,"AKT3, BRAF, PIK3CB, RPS6KA6, RPS6KA2, RICTOR, CAB39, AKT1, PIK3R1, MAPK3, MAPK1, TSC1, PIK3R3, RHEB, RPS6KA1",0.826813731587726,0.385102783966865,FALSE
+"H520","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.51619,-1.55,0.0695,5683,0.356,"GRB2, BRAF, PTPN6, PIK3CB, PPP3CB, PPP3CA, PLCG1, IFNAR1, PIK3R1, PRKCA, NFATC2, MAPK3, MAPK1, SHC1, PIK3R3, FAS, IFNGR1, BID, SOS1, ICAM2, RAET1L, ULBP2, PRKCB, ZAP70, VAV2, RAC3, PPP3R1, PLCG2, PRKCG, ICAM1, ITGB2, TNFRSF10D, RAC2",1.15801519540989,0.448550002027125,FALSE
+"H520","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.34073,-1.02,0.382,6304,0.543,"CHRNE, NR3C1, PARD3, FPR2, TSPO, PLG, HCRTR1",0.417936637088291,0.265200170411153,FALSE
+"H520","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.48462,-1.45,0.0792,5683,0.373,"GRB2, BRAF, RPS6KA4, MAP3K5, PIK3CB, CRK, NFKB1, PLCG1, RPS6KA6, NFKBIB, IRAK4, RPS6KA2, MAPKAPK2, ZNF274, NGFR, CAMK2D, AKT1, PIK3R1, YWHAZ, MAPK3, ABL1, RHOA, MAPK1, SHC1, YWHAE, YWHAQ, IRS2, PIK3R3, SOS1, ARHGDIA, YWHAG, YWHAH, YWHAB, CRKL, TP53, RPS6KA1, PLCG2, IRS1, PRKCD, IKBKB, ARHGDIB, RPS6KA5",1.10127481841051,0.428291168191312,FALSE
+"H520","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.4936,-1.48,0.0801,7280,0.373,"ENPP1, NT5C2, NNMT, PNP, QPRT, NAMPT, NT5E",1.09636748391576,0.428291168191312,FALSE
+"H520","Input","KEGG_NITROGEN_METABOLISM",0.41043,1.27,0.188,106,0.363,"CA8, GLUD2",0.72584215073632,0.440093374963888,FALSE
+"H520","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.57708,-1.72,0.0342,5875,0.519,"CCL13, NFKB1, SUGT1, NFKBIB, TAB1, HSP90AB1, CASP8, CHUK, MAPK3, HSP90AA1, MAPK1, BIRC2, IKBKG, TAB2, MAP3K7, TAB3, IKBKB, IL6, IL18, TRIP6",1.46597389394386,0.284832642151542,FALSE
+"H520","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.23537,-0.709,0.821,7371,0.876,"XRCC4",0.0856568428805592,0.0574958938319193,FALSE
+"H520","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.51999,-1.57,0.0617,6266,0.385,"AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, ERBB2, PIK3R3, SOS1, CDK4, CCND1, EGFR, PRKCB, TP53, PLCG2, STK4, CDKN2A, PRKCG, RXRG",1.20971483596676,0.414539270491499,FALSE
+"H520","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.15114,-0.444,1,6322,0.999,"NUMB, DTX3L, NOTCH2, NUMBL, NCOR2, NOTCH3",0,0.000434511774017692,FALSE
+"H520","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.24838,-0.745,0.782,5785,0.83,"POLD3, ERCC5, RBX1, RAD23A, RPA3, POLD1, POLD4, POLE3, POLE2, LIG1, POLE, PCNA, RAD23B, DDB2",0.106793246940152,0.0809219076239261,FALSE
+"H520","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.5139,1.63,0.042,1249,0.262,"MAN2A1, MAN1A1, ALG9, MGAT1, ALG3, STT3A, MAN1C1, DOLPP1, ST6GAL1, ALG5, MOGS, ALG1, GANAB, RPN2",1.3767507096021,0.581698708680255,FALSE
+"H520","Input","KEGG_OLFACTORY_TRANSDUCTION",0.22785,0.723,0.838,1766,0.891,"CNGB1, PRKACB, CALML3",0.0767559813697235,0.0501222959631252,FALSE
+"H520","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.44863,1.43,0.107,1173,0.266,"MTHFS, MTHFR, MTHFD2, MTFMT, MTHFD1L",0.97061622231479,0.575118363368933,FALSE
+"H520","Input","KEGG_OOCYTE_MEIOSIS",-0.37421,-1.13,0.274,5628,0.458,"CDK2, PPP1CA, PPP2CB, CDC26, PPP3CB, PPP2R5A, PPP2R1A, PPP3CA, RBX1, RPS6KA6, AR, RPS6KA2, CAMK2D, PRKACA, YWHAZ, MAPK3, PLK1, AURKA, MAPK1, YWHAE, YWHAQ, YWHAG, YWHAH, STAG3, YWHAB, CCNB1, RPS6KA1, MOS, PPP3R1, ITPR3, ADCY9, IGF1R",0.562249437179612,0.339134521996131,FALSE
+"H520","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.20708,0.667,0.916,317,0.914,"MANBA",0.0381045263321496,0.0390538042661686,FALSE
+"H520","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.49024,1.58,0.0727,2838,0.27,"SDHD, ATP5MC2, NDUFA6, ATP5F1C, NDUFS7, UQCRH, ATP6V0A1, ATP5PO, COX11, ATP5PB, ATP5MG, ATP5F1B, ATP5F1E, ATP6V0A2, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, ATP5ME, NDUFA4, NDUFB7, SDHC, NDUFB4, NDUFS8, NDUFS6, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP6V1B2, ATP5PD, NDUFA10, NDUFB8, ATP12A, NDUFV1, ATP6V1D, ATP6V1H, SDHB, NDUFS4, NDUFS3, COX4I1, NDUFAB1, NDUFS1, COX7C, NDUFS2, ATP6V0D1, NDUFB2, ATP6AP1, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, ATP6V1A, UQCRQ, ATP6V1E1, NDUFB10, SDHA, ATP6V1G1, NDUFB9, NDUFC1, UQCRC1",1.13846558914096,0.568636235841013,FALSE
+"H520","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.36792,1.14,0.258,986,0.453,"GCNT1, GALNT10, GALNT6",0.58838029403677,0.343901797987168,FALSE
+"H520","Input","KEGG_P53_SIGNALING_PATHWAY",-0.48802,-1.46,0.1,6533,0.373,"CASP8, RCHY1, CHEK2, RRM2, FAS, SERPINB5, BID, CDK4, CCND1, APAF1, TP53, CCNB1, DDB2, CD82, CDKN2A, SERPINE1",1,0.428291168191312,FALSE
+"H520","Input","KEGG_PANCREATIC_CANCER",-0.38737,-1.18,0.243,6667,0.447,"CHUK, MAPK3, MAPK1, ERBB2, PIK3R3, IKBKG, CDK4, STAT1, CCND1, EGFR, TP53, RAC3, TGFB1, TGFBR2, IKBKB, CDKN2A, RAC2",0.614393726401688,0.349692476868064,FALSE
+"H520","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.39467,-1.18,0.262,6861,0.447,"BCAT2, ENPP1, DPYD",0.581698708680255,0.349692476868064,FALSE
+"H520","Input","KEGG_PARKINSONS_DISEASE",0.42956,1.34,0.142,2560,0.314,"SLC25A4, UCHL1, SDHD, ATP5MC2, NDUFA6, ATP5F1C, NDUFS7, UQCRH, VDAC1, ATP5PO, ATP5PB, ATP5F1B, ATP5F1E, VDAC3, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, NDUFA4, NDUFB7, SLC25A31, SDHC, NDUFB4, NDUFS8, SLC25A5, NDUFS6, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP5PD, NDUFA10, NDUFB8, SLC25A6, NDUFV1, VDAC2, SDHB, NDUFS4, NDUFS3, COX4I1, NDUFAB1, NDUFS1, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, UQCRQ, SNCA",0.847711655616944,0.503070351926785,FALSE
+"H520","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.34035,-1.03,0.38,5780,0.534,"TUBB, ARPC3, TUBA1C, ARPC2, OCLN, HCLS1, ACTB, PRKCA, WASL, YWHAZ, ROCK2, WAS, ABL1, RHOA, CTTN, ROCK1, YWHAQ, TUBB1, TUBB3, ARPC1B, ARPC5, CDH1, ITGB1, TUBB4B, EZR, TUBA4A",0.42021640338319,0.272458742971444,FALSE
+"H520","Input","KEGG_PATHWAYS_IN_CANCER",-0.37667,-1.13,0.279,5628,0.458,"CDK2, CTNNA1, STAT3, ITGA2, GRB2, BRAF, DVL2, MITF, STAT5A, CTBP2, PIK3CB, CRK, RALBP1, NFKB1, MSH3, PLCG1, MMP2, RBX1, CUL2, AR, ELOC, ELOB, JAK1, AKT1, PIK3R1, TFG, PRKCA, MSH2, TRAF2, HSP90AB1, CASP8, PML, BCR, FADD, CHUK, MAPK3, ABL1, MLH1, HSP90AA1, RHOA, MAPK1, MET, ERBB2, BIRC5, CCDC6, NCOA4, BIRC2, PIK3R3, TRAF5, FAS, IKBKG, COL4A1, DAPK1, BID, HGF, SOS1, ITGA2B, CDK4, CKS1B, CDH1, STAT1, CCND1, ITGB1, EGFR, CRKL, PRKCB, TP53, LAMA3, LAMA4, TRAF1, RAC3, TPM3, TGFB1, ITGAV, PLCG2, TGFBR2, LAMB3, LAMB1, DAPK3, IKBKB, STK4, IL6, CDKN2A, PRKCG, RXRG, ITGA3, PTGS2, IGF1R, ETS1, RAC2",0.554395796726402,0.339134521996131,FALSE
+"H520","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.40957,-1.23,0.192,5708,0.43,"GUSB, AKR1B1, UGP2, RPE, UGDH, XYLB",0.71669877129645,0.366531544420413,FALSE
+"H520","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.4555,-1.38,0.129,5189,0.381,"TALDO1, TKT, H6PD, PGM2, ALDOC, RPE, FBP2, RBKS, RPIA, PFKL, G6PD, DERA, ALDOA, PGM1, PFKP",0.889410289700751,0.419075024324381,FALSE
+"H520","Input","KEGG_PEROXISOME",0.30174,0.939,0.486,797,0.654,"PIPOX, PRDX1, SOD1, PECR, SLC27A2, MLYCD, PAOX, ACSL5, PEX12",0.313363730737707,0.184422251675733,FALSE
+"H520","Input","KEGG_PHENYLALANINE_METABOLISM",0.73163,2.28,0.00487,282,0.224,"MAOB, ALDH3A1, MAOA, GOT2",2.31247103878537,0.649751981665837,TRUE
+"H520","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.40811,-1.22,0.2,5775,0.421,"PIK3CB, OCRL, ITPKB, PLCG1, CDS2, DGKZ, PIK3R1, PRKCA, PIP4K2C, SYNJ2, CDS1, DGKH, PLCB3, PIK3R3, INPP1, PLCD3, PRKCB, PLCG2, ITPK1, IMPA2, ITPR3, ITPKA, PRKCG, INPP4B, DGKA",0.698970004336019,0.375717904164332,FALSE
+"H520","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.28697,0.886,0.546,502,0.68,"UROD, FECH, EARS2",0.262807357295263,0.167491087293764,FALSE
+"H520","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2927,-0.871,0.563,6896,0.687,"SCP2, APOA1, ILK, DBI, LPL, ACSL4, SCD5, HMGCS2, FABP3, RXRG, PLTP",0.249491605148654,0.16304326294045,FALSE
+"H520","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.63243,1.99,0.0156,654,0.256,"AKR1D1, CYP27A1",1.80687540164554,0.59176003468815,FALSE
+"H520","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.39409,-1.16,0.249,6020,0.47,"TAP1, TAP2, ADA, CD40, IKBKG, ZAP70",0.603800652904264,0.327902142064283,FALSE
+"H520","Input","KEGG_PRION_DISEASES",0.44472,1.38,0.113,217,0.297,"C9, NCAM1, SOD1",0.94692155651658,0.527243550682788,FALSE
+"H520","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.38646,-1.15,0.266,5533,0.471,"AKT3, CDK2, BRAF, PIK3CB, CDC26, RPS6KA6, RPS6KA2, AKT1, PIK3R1, PRKACA, HSP90AB1, MAPK3, HSP90AA1, PLK1, MAPK1, CCNA2, PIK3R3, FZR1, CCNB1, RPS6KA1, MOS, ADCY9, IGF1R",0.575118363368933,0.326979092871104,FALSE
+"H520","Input","KEGG_PROPANOATE_METABOLISM",0.46117,1.43,0.119,1311,0.266,"ACSS3, ALDH2, HIBCH, ALDH3A2, MLYCD, SUCLA2, PCCA, PCCB, ALDH7A1, ALDH9A1",0.924453038607469,0.575118363368933,FALSE
+"H520","Input","KEGG_PROSTATE_CANCER",-0.30533,-0.914,0.538,5450,0.654,"RELA, CREB5, AKT3, CDK2, GRB2, BRAF, PIK3CB, NFKB1, AR, AKT1, PIK3R1, HSP90AB1, CHUK, MAPK3, HSP90AA1, MAPK1, ERBB2, PIK3R3, IKBKG, SOS1, CCND1, EGFR, TP53, IKBKB, IGF1R",0.269217724333611,0.184422251675733,FALSE
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+"H520","Input","KEGG_VIRAL_MYOCARDITIS",-0.57258,-1.69,0.045,6409,0.425,"MYH10, DAG1, CASP8, ABL1, CD40, BID, CAV1, CCND1, CD55, RAC3, MYH11, MYH9, MYH14, MYH7B, ICAM1, ITGB2, RAC2",1.34678748622466,0.371611069949688,FALSE
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diff --git a/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_venn_diagram.pdf b/Examples/cell_corr/Fig5 - Coldren prot/GSEA/GSEA_venn_diagram.pdf
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index 0000000..cc377e6
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new file mode 100644
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diff --git a/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_correlation_matrix.pdf b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_correlation_matrix.pdf
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diff --git a/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_dot_plot.pdf b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_dot_plot.pdf
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diff --git a/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_interactive_network.graph.html b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
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--- /dev/null
+++ b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_interactive_network.graph.html	
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
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+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
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+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNFQxNDo0MTowNCswMTowMDwveG1wOk1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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-2eeb6cff3db6321ed8bd" style="width:960px;height:500px;"></div>
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diff --git a/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..6a0db61
--- /dev/null
+++ b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_mean_results.csv	
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+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"MDM inhibitor",0.61505,1.2322415379684,0.000145116304689573,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"HCC95, H1648, HCC827, H2009",0.000708509017013798
+"retinoid receptor agonist",0.5428,1.3641660880514,1.54628289517376e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H1648, H2126, HCC44",9.87242156149402e-05
+"bacterial DNA gyrase inhibitor",0.53395,1.11615238890716,0.0138837300852224,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.0371725676475311
+"adrenergic receptor antagonist",0.4275,0.704636487096268,0.999709613483481,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055
+"benzodiazepine receptor agonist",0.3917,0.791587352628947,0.995411169605698,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055
+"BCL inhibitor",0.37655,1.16843775480002,0.0451365090014476,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC44",0.0985876380821093
+"sterol demethylase inhibitor",0.3461,1.19563305847836,0.032389666410513,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H2009",0.0746761753353493
+"acetylcholine receptor antagonist",0.29795,1.35306044813814,0.00304025399837317,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC4006, H460, H1299",0.0097054262255759
+"DNA inhibitor",0.267,0.8149782044228,0.998636801435584,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055
+"bromodomain inhibitor",0.266,2.01562423398598,5.13300386315732e-11,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,14,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2009, HCC2279, H520, HCC15, H460, HCC44, H1299",4.26039320642058e-09
+"TGF beta receptor inhibitor",0.22885,1.10245201709644,0.214936822386624,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.356795125161795
+"PPAR receptor agonist",0.21995,1.02146708090296,0.531887171536959,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.723715331763403
+"PI3K inhibitor",0.1995,1.10661786776789,0.363837156977989,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1648, HCC44",0.549063345984966
+"HMGCR inhibitor",0.14345,2.0513456809206,1.30308365978555e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,12,"H358, H1650, H3255, H1975, HCC78, H2126, H2009, HCC4006, HCC2279, HCC15, HCC44, H1299",9.01299531351674e-05
+"proteasome inhibitor",0.1258,1.07236696389956,0.590378029141691,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"A549",0.75386732951939
+"ATPase inhibitor",0.12365,0.968844850704612,0.90694560812152,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055
+"PARP inhibitor",0.1064,1.18423519178991,0.0598434586043851,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.124175176604099
+"protein synthesis inhibitor",0.1008,1.15083715981934,0.18548285284487,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.320730766377588
+"glutamate receptor antagonist",0.09955,1.32616127760183,0.00250856020606875,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1650, HCC78, H2009, HCC15",0.00832841988414826
+"vitamin D receptor agonist",0.0962,1.34228362364881,0.00034220015351446,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC44",0.00143573185379231
+"calcium channel blocker",0.0774500000000001,1.32676716217714,0.00099955407026891,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.00377104490146907
+"RET tyrosine kinase inhibitor",0.0774000000000001,1.54086525248504,5.77785175903458e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H1648, HCC78, H2126, HCC2279, HCC15, HCC44, H1299",9.5912339199974e-07
+"p38 MAPK inhibitor",0.0754000000000001,1.18790458592564,0.0663809593809252,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.131181419728971
+"DNA methyltransferase inhibitor",0.0721,1.49604101759136,1.47474728750385e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H358, H3255, H1648, HCC78, H2009, HCC4006, HCC15",3.0601006215705e-07
+"ribonucleotide reductase inhibitor",0.0639,0.914222355769904,0.976855965003178,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055
+"serotonin receptor antagonist",0.0465500000000001,1.14335487307724,0.265645268308797,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.424010716723657
+"sodium channel blocker",0.03555,1.00664452906413,0.851671294227971,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.969566778409323
+"tubulin polymerization inhibitor",0.0320499999999999,1.28920136334987,0.00161975489504299,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC2279, H520, H460",0.00584520244732904
+"FGFR inhibitor",0.0276500000000001,1.23469119407925,0.0246238115000805,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1648",0.061643404745328
+"VEGFR inhibitor",0.0246,1.05729537773958,0.647286672796522,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.814012027910777
+"cyclooxygenase inhibitor",0.01715,0.740179300824078,0.999997150505055,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055
+"PLK inhibitor",0.0106500000000001,1.58124036173472,3.58239250709438e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,9,"H1650, H3255, HCC78, H2126, HCC2279, H520, HCC15, H460, H1299",1.18409164929212e-07
+"AKT inhibitor",-0.00365000000000006,1.43010192036497,3.60853205436968e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1648, HCC4006, HCC2279, HCC15",4.27868800732405e-05
+"adenosine receptor antagonist",-0.00470000000000001,1.3338381145362,0.00808035904655401,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H3255, H1975",0.0239524928879994
+"PDGFR tyrosine kinase receptor inhibitor",-0.00715000000000001,1.10921737582951,0.391200964864684,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.579815715781585
+"mTOR inhibitor",-0.0165000000000001,1.15589334328589,0.195376986808872,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.330944691941559
+"Aurora kinase inhibitor",-0.04585,1.48762743903453,4.27984933479079e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H1650, H1648, HCC78, HCC4006, HCC2279, HCC15, H460",1.18409164929212e-07
+"topoisomerase inhibitor",-0.0461,1.17780106889692,0.0617206725813804,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1648, HCC2279",0.124946727420843
+"estrogen receptor agonist",-0.0583,1.20994223872573,0.0791436753718466,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.14929375126962
+"HSP inhibitor",-0.0634,1.08178801308905,0.464466540081523,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.664667634944248
+"KIT inhibitor",-0.0641,1.07961249870888,0.483109466556363,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.668301428736302
+"RAF inhibitor",-0.09,1.25110431219783,0.0109903797655942,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1299",0.0304067173514772
+"EGFR inhibitor",-0.0909,1.02185244068129,0.481790835582359,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.668301428736302
+"FLT3 inhibitor",-0.0982,1.21462771424438,0.0194905268913824,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1299",0.0505535541245232
+"cytochrome P450 inhibitor",-0.1031,1.60203179875136,3.3913576132178e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,6,"H358, H1650, H3255, H1648, HCC2279, H460",4.27868800732405e-05
+"phosphatase inhibitor",-0.10515,0.967201621336415,0.933978258295636,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055
+"estrogen receptor antagonist",-0.11125,1.13639674664682,0.157459892823631,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC44",0.284112415312204
+"DNA polymerase inhibitor",-0.13405,0.999527334346221,0.844759851827795,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.969566778409323
+"opioid receptor agonist",-0.1425,1.39185379979364,0.000241539618550126,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H358, H1650, H1648, H2126",0.00111376601887003
+"glucocorticoid receptor agonist",-0.1607,1.10130420769864,0.236217488060158,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.384432382529277
+"dopamine receptor antagonist",-0.1984,0.86542380247757,0.994897841851579,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055
+"NFkB pathway inhibitor",-0.2011,1.05578481160749,0.453102960313756,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.659781503614768
+"bacterial 50S ribosomal subunit inhibitor",-0.21955,0.997874133767433,0.742636125088984,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.906452917388025
+"microtubule inhibitor",-0.22795,1.10401475366763,0.170869477035346,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H460",0.301748225402845
+"thymidylate synthase inhibitor",-0.2299,1.35964449300853,1.10798782454047e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1648, HCC78",8.36027176698718e-05
+"histamine receptor antagonist",-0.23975,0.759926442077403,0.999963892942649,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999997150505055
+"androgen receptor antagonist",-0.24695,1.65162629502592,4.91157477484915e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,8,"H3255, H1648, HCC4006, HCC2279, HCC15, H460, H1703, H1299",5.095758828906e-05
+"potassium channel blocker",-0.24845,1.16754260488024,0.109222904832103,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H3255",0.201455580023657
+"HCV inhibitor",-0.25855,1.08147864056578,0.34269014386723,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.526727443351483
+"phosphodiesterase inhibitor",-0.26055,1.03700172435526,0.561418319585173,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.751576137509183
+"growth factor receptor inhibitor",-0.27215,1.30130615658188,0.00034595948284152,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H520, H1299",0.00143573185379231
+"adrenergic receptor agonist",-0.28245,0.988356662397367,0.727267485057901,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.90094330238516
+"DNA synthesis inhibitor",-0.28955,0.949400723725512,0.881529688425416,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.988742758639318
+"DNA alkylating agent",-0.2977,1.02007466702972,0.587133701708533,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.75386732951939
+"serotonin receptor agonist",-0.30305,1.34232298548763,0.00403539258321259,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1975, H520, A549, H1299",0.0124050957187646
+"ALK tyrosine kinase receptor inhibitor",-0.30705,0.935512551605015,0.852751503902176,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.969566778409323
+"tyrosine kinase inhibitor",-0.3289,0.964588589694291,0.756086717032928,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.909495616141059
+"JAK inhibitor",-0.3435,1.00415796094355,0.575097989039066,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.75386732951939
+"protein tyrosine kinase inhibitor",-0.36185,1.200645847034,0.00229379431815644,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H358, H3255, HCC4006",0.00793270535029103
+"HDAC inhibitor",-0.36835,1.31120656668822,0.000556338731126338,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC78, HCC2279, HCC15",0.00219886260397553
+"CC chemokine receptor antagonist",-0.3728,1.1581719079744,0.0409854160979159,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0919402577331627
+"CDK inhibitor",-0.3777,1.37443546688507,1.10405361480619e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,5,"H358, HCC78, HCC2279, H460, H1299",8.36027176698718e-05
+"AP inhibitor",-0.4205,1.50089876582771,2.26144961223966e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H358, H1650, H2126, CALU3, HCC15, A549, HCC44",0.00013407165558278
+"src inhibitor",-0.57995,1.09395513595105,0.0252515151968814,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1975",0.061643404745328
+"progesterone receptor agonist",-0.5833,1.0214453691242,0.0588040918242428,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1648, H1975",0.124175176604099
+"Bcr.Abl kinase inhibitor",-0.5874,1.11023323296456,0.0266088170838195,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.0631009090844861
+"MET inhibitor",-0.63625,1.38278665534873,2.70772064645311e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,6,"H1650, HCC95, H3255, H1648, H1975, H520",0.000149827209103739
+"glycogen synthase kinase inhibitor",-0.6492,0.768857635169148,0.790305414936758,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.93707642056787
+"Abl kinase inhibitor",-0.67955,0.981613198287712,0.077184141256562,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1975",0.148983342425457
+"MEK inhibitor",-0.75255,0.777958832289243,0.293282217627469,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC827",0.459291020058112
+"CHK inhibitor",-0.8106,1.22841744147758,9.20604740145148e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"HCC95, H1975, HCC827, HCC44",8.36027176698718e-05
+"acetylcholine receptor agonist",-0.8695,0.888479511359301,0.0101420833981925,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H460",0.0290273421396545
+"antioxidant",-0.9436,1.03873867844866,9.07240468663416e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1650, H1648, H1975, HCC2279",0.000470630993119147
diff --git a/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..1cb1524
--- /dev/null
+++ b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_results.csv	
@@ -0,0 +1,1661 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H358","Pearson.est","EGFR inhibitor",-0.6517,-1.55,0.031,1083,0.321,"BIBX.1382, poziotinib, tyrphostin.AG.1478, AEE788, BMS.690514, WZ8040, WZ.4002, lapatinib, erlotinib, CP.724714, canertinib, pelitinib, rociletinib, BMS.599626, TAK.285, PD.153035, gefitinib, dacomitinib, XL.647, GW.583340, AZD8931, tucatinib, BIBU.1361, osimertinib, afatinib, CUDC.101, neratinib, ARRY.334543, AST.1306",1.50863830616573,0.493494967595128,FALSE
+"H358","Pearson.est","Abl kinase inhibitor",-0.38684,-0.915,0.6,1017,0.807,"ZM.306416, imatinib, tozasertib, bafetinib, bosutinib, KW.2449",0.221848749616356,0.0931264652779296,FALSE
+"H358","Pearson.est","acetylcholine receptor agonist",-0.58163,-1.4,0.102,1016,0.47,"xanomeline, nefiracetam, pilocarpine",0.991399828238082,0.327902142064283,FALSE
+"H358","Pearson.est","acetylcholine receptor antagonist",0.47989,1.44,0.117,756,0.299,"darifenacin, iododexetimide, hyoscyamine, methscopolamine, diphemanil, dicycloverine",0.931814138253838,0.52432881167557,FALSE
+"H358","Pearson.est","adenosine receptor antagonist",-0.44247,-1.06,0.397,729,0.742,"istradefylline, SCH.58261, PSB.1115, MRS.1220, CGS.15943",0.401209493236885,0.129596094720973,FALSE
+"H358","Pearson.est","adrenergic receptor agonist",0.24075,0.726,0.765,1103,0.903,"lidamidine, xylazine, epinephrine, terbutaline, methyldopa, oxymetazoline, ritodrine, A61603, norepinephrine, buphenine, isoetharine, midodrine, clenbuterol, metaraminol, isoxsuprine",0.116338564846382,0.0443122496864942,FALSE
+"H358","Pearson.est","adrenergic receptor antagonist",-0.27247,-0.65,0.91,691,0.974,"carvedilol, propranolol, oxprenolol, dihydroergocristine, prazosin, levobunolol, vincamine, dronedarone, atenolol......, naftidrofuryl, atipamezole",0.0409586076789064,0.0114410431213845,FALSE
+"H358","Pearson.est","AKT inhibitor",-0.61414,-1.47,0.0535,1030,0.374,"palomid.529, AZD5363, CCT128930, GSK2110183, GDC.0068, A.674563, triciribine, uprosertib",1.27164621797877,0.42712839779952,FALSE
+"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.30241,-0.719,0.846,822,0.974,"AP26113, NVP.TAE684, alectinib, CEP.37440, DMH1, AZD3463",0.0726296369609765,0.0114410431213845,FALSE
+"H358","Pearson.est","androgen receptor antagonist",0.42025,1.29,0.165,842,0.401,"bicalutamide, RU.58841, flutamide, cyproterone.acetate, nilutamide, enzalutamide",0.782516055786094,0.396855627379818,FALSE
+"H358","Pearson.est","antioxidant",0.30374,0.96,0.489,1010,0.704,"rutin, trolox, mesna, benfotiamine, chlorogenic.acid, taurine",0.31069114087638,0.152427340857888,FALSE
+"H358","Pearson.est","AP inhibitor",0.60909,1.79,0.0294,51,0.212,"birinapant, GDC.0152, idronoxil",1.53165266958784,0.673664139071249,TRUE
+"H358","Pearson.est","ATPase inhibitor",-0.24609,-0.58,0.932,1164,0.99,"NMS.873, oligomycin.a, evodiamine",0.0305840876460186,0.00436480540245009,FALSE
+"H358","Pearson.est","Aurora kinase inhibitor",-0.68507,-1.63,0.0284,1072,0.25,"GSK1070916, aurora.a.inhibitor.i, tozasertib, barasertib, ENMD.2076, danusertib, AMG900, PF.03814735, PHA.680632, CYC116, alisertib, ZM.447439, KW.2449, MK.8745, AT.9283, hesperadin, barasertib.HQPA, SNS.314, CCT137690",1.54668165995296,0.602059991327962,FALSE
+"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.46955,-1.13,0.312,814,0.683,"tilmicosin, azithromycin, tedizolid, valnemulin, radezolid, azalomycin.b",0.505845405981557,0.165579296318467,FALSE
+"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.36234,1.13,0.295,144,0.612,"sparfloxacin, lomefloxacin, sarafloxacin",0.530177984021837,0.213248577854439,FALSE
+"H358","Pearson.est","BCL inhibitor",-0.38984,-0.942,0.528,1292,0.79,"TW.37, gossypol",0.277366077466188,0.102372908709559,FALSE
+"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.29645,-0.713,0.843,1037,0.963,"imatinib, tozasertib, bafetinib, bosutinib",0.0741724253752577,0.0163737128754655,FALSE
+"H358","Pearson.est","benzodiazepine receptor agonist",0.22134,0.702,0.87,174,0.837,"gamma.aminobutyric.acid, eprinomectin, indiplon, CL.218872",0.0604807473813815,0.07727454200674,FALSE
+"H358","Pearson.est","bromodomain inhibitor",-0.89875,-2.17,0,1296,0.00089,"PFI.1, bromosporine, I.BET.762, I.BET151, JQ1...., OTX015",Inf,3.05060999335509,TRUE
+"H358","Pearson.est","calcium channel blocker",-0.419,-0.991,0.503,1057,0.779,"mibefradil, penfluridol, tetrandrine, cinnarazine, carboxyamidotriazole",0.298432014944073,0.108462542327436,FALSE
+"H358","Pearson.est","CC chemokine receptor antagonist",-0.4256,-1.02,0.455,1252,0.753,"SB.225002, ZK811752",0.341988603342888,0.123205023799299,FALSE
+"H358","Pearson.est","CDK inhibitor",-0.78518,-1.87,0,1228,0.0565,"indirubin, ribociclib, aminopurvalanol.a, PHA.793887, R547, alvocidib, JNJ.7706621, abemaciclib, arcyriaflavin.a, P276.00, indisulam, palbociclib, AZD5438, kenpaullone, BMS.265246, AT.7519, dinaciclib, TG.02, BMS.387032",Inf,1.24795155218056,TRUE
+"H358","Pearson.est","CHK inhibitor",0.23134,0.72,0.865,256,0.861,"SCH.900776, PF.477736, AZD7762",0.0629838925351858,0.0649968485463452,FALSE
+"H358","Pearson.est","cyclooxygenase inhibitor",-0.23974,-0.575,0.949,1086,0.977,"phenazone, ketoprofen, ramifenazone, FR.122047, tryptanthrin, aspirin",0.0227337875727074,0.0101054362812269,FALSE
+"H358","Pearson.est","cytochrome P450 inhibitor",0.55833,1.67,0.0229,212,0.182,"eplerenone, metyrapone, clotrimazole, morin",1.64016451766011,0.739928612014925,TRUE
+"H358","Pearson.est","DNA alkylating agent",-0.39064,-0.942,0.555,1079,0.79,"estramustine, streptozotocin, cyclophosphamide, TH.302, mitomycin.c",0.255707016877324,0.102372908709559,FALSE
+"H358","Pearson.est","DNA inhibitor",-0.328,-0.787,0.751,1390,0.919,"oxaliplatin, primaquine",0.124360062995832,0.0366844886138887,FALSE
+"H358","Pearson.est","DNA methyltransferase inhibitor",-0.70221,-1.67,0.0161,1311,0.231,"decitabine, fdcyd, azacitidine",1.79317412396815,0.636388020107856,TRUE
+"H358","Pearson.est","DNA polymerase inhibitor",-0.39424,-0.942,0.555,1302,0.79,"trifluridine, idoxuridine",0.255707016877324,0.102372908709559,FALSE
+"H358","Pearson.est","DNA synthesis inhibitor",-0.53334,-1.26,0.184,1389,0.603,"anisomycin, cyclocytidine, mitomycin.c",0.735182176990464,0.219682687859849,FALSE
+"H358","Pearson.est","dopamine receptor antagonist",-0.3963,-0.939,0.558,896,0.778,"piperacetazine, mesoridazine, paliperidone, lurasidone, UH.232...., acetophenazine, thioproperazine, sertindole",0.253365801062421,0.109020403010311,FALSE
+"H358","Pearson.est","estrogen receptor agonist",0.2875,0.855,0.647,1034,0.853,"estradiol.cypionate, ethinyl.estradiol, PPT, equol, estrone, estradiol, erteberel, levonorgestrel",0.1890957193313,0.069050968832477,FALSE
+"H358","Pearson.est","estrogen receptor antagonist",-0.54697,-1.31,0.145,1419,0.533,"clomifene",0.838631997765025,0.273272790973428,FALSE
+"H358","Pearson.est","FGFR inhibitor",0.28032,0.851,0.603,117,0.801,"lenvatinib, erdafitinib, dovitinib",0.219682687859849,0.0963674839157623,FALSE
+"H358","Pearson.est","FLT3 inhibitor",-0.48381,-1.16,0.251,956,0.677,"GTP.14564, tandutinib, TG.101348, lestaurtinib, tozasertib, ENMD.2076, KW.2449, sorafenib, TG.02, pacritinib",0.600326278518962,0.169411331314856,FALSE
+"H358","Pearson.est","glucocorticoid receptor agonist",-0.50407,-1.21,0.227,949,0.649,"fludroxycortide, dexamethasone.acetate, prednisolone, halcinonide, clobetasol.propionate, triamcinolone.acetonide, betamethasone, desonide, prednisolone.hemisuccinate, flumethasone.pivalate, difluprednate, methylprednisolone, ciclesonide, halobetasol.propionate, flumethasone, deflazacort, rimexolone",0.643974142806877,0.187755303199631,FALSE
+"H358","Pearson.est","glutamate receptor antagonist",0.51154,1.51,0.0923,94,0.272,"latrepirdine, CGP.37849, JNJ.16259685, kynurenic.acid",1.03479829897409,0.565431095965801,FALSE
+"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.29618,-0.702,0.848,1228,0.942,"indirubin, kenpaullone",0.0716041477432862,0.0259490972071227,FALSE
+"H358","Pearson.est","growth factor receptor inhibitor",-0.59569,-1.43,0.078,967,0.433,"GSK1838705A, GSK1904529A, lestaurtinib, PHA.848125, danusertib, AZD3463",1.10790539730952,0.363512103646635,FALSE
+"H358","Pearson.est","HCV inhibitor",-0.45754,-1.09,0.349,887,0.736,"Ro.9187, PSI.7976, mericitabine, narlaprevir",0.45717457304082,0.133122185662501,FALSE
+"H358","Pearson.est","HDAC inhibitor",-0.52434,-1.25,0.208,1149,0.573,"resminostat, SB.939, AR.42, PCI.24781, trichostatin.a, belinostat, dacinostat, RG2833, vorinostat, scriptaid, givinostat, M.344, R306465",0.681936665037238,0.24184537803261,FALSE
+"H358","Pearson.est","histamine receptor antagonist",-0.22251,-0.535,0.969,763,0.967,"pheniramine, ebastine, BF2.649, cyproheptadine, famotidine, levocetirizine, astemizole, tiotidine, terfenadine",0.0136762229492347,0.0145735259169983,FALSE
+"H358","Pearson.est","HMGCR inhibitor",0.94707,2.79,0,55,0,"pitavastatin, fluvastatin, atorvastatin, mevastatin, simvastatin",Inf,Inf,TRUE
+"H358","Pearson.est","HSP inhibitor",-0.50178,-1.2,0.229,941,0.62,"BIIB021, SNX.5422, NVP.AUY922, PU.H71, XL888, alvespimycin, tanespimycin",0.640164517660112,0.207608310501746,FALSE
+"H358","Pearson.est","JAK inhibitor",-0.53277,-1.26,0.188,943,0.603,"WHI.P154, TG.101348, LY2784544, lestaurtinib, tozasertib, atiprimod, filgotinib, AZ960, TG.101209, AT.9283, TG.02, pacritinib",0.72584215073632,0.219682687859849,FALSE
+"H358","Pearson.est","KIT inhibitor",-0.34403,-0.821,0.708,948,0.884,"vatalanib, tandutinib, imatinib, pazopanib, regorafenib, sorafenib, OSI.930",0.149966742310231,0.0535477349869269,FALSE
+"H358","Pearson.est","MDM inhibitor",0.26352,0.769,0.757,1068,0.896,"AMG.232, idasanutlin, CGM097, nutlin.3, RITA, serdemetan",0.120904120499927,0.0476919903378748,FALSE
+"H358","Pearson.est","MEK inhibitor",-0.55349,-1.32,0.13,916,0.574,"nobiletin, TAK.733, refametinib, Ro.4987655, selumetinib, arctigenin, PD.198306, PD.184352, cobimetinib, AS.703026, PD.0325901, AZD8330, MEK162, trametinib",0.886056647693163,0.241088107602027,FALSE
+"H358","Pearson.est","MET inhibitor",0.46186,1.38,0.0738,782,0.332,"PF.04217903, LY2801653, PHA.665752, AMG458, NVP.BVU972, INC.280",1.13194363817696,0.478861916295964,FALSE
+"H358","Pearson.est","microtubule inhibitor",-0.56639,-1.37,0.105,914,0.475,"colchicine, cytochalasin.b, podophyllotoxin, cabazitaxel, vinflunine, D.64131",0.978810700930062,0.323306390375133,FALSE
+"H358","Pearson.est","mTOR inhibitor",-0.452,-1.08,0.363,1020,0.715,"XL388, palomid.529, PP242, ku.0063794, WYE.354, torin.2, MLN0128, AZD2014, GDC.0980, AZD8055, WYE.125132, GSK2126458",0.440093374963888,0.145693958198919,FALSE
+"H358","Pearson.est","NFkB pathway inhibitor",-0.46941,-1.13,0.288,797,0.683,"parthenolide, tyloxapol, curcumin, Ro.106.9920, parthenolide...., bortezomib, IKK.2.inhibitor.V, EVP4593, betulinic.acid",0.540607512240769,0.165579296318467,FALSE
+"H358","Pearson.est","opioid receptor agonist",0.5422,1.69,0.0365,56,0.22,"BW.180C, spiradoline",1.43770713554353,0.657577319177794,TRUE
+"H358","Pearson.est","p38 MAPK inhibitor",-0.48825,-1.16,0.287,859,0.677,"CMPD.1, skepinone.l, SB.242235, SB.239063, talmapimod",0.542118103266008,0.169411331314856,FALSE
+"H358","Pearson.est","PARP inhibitor",-0.37067,-0.883,0.627,664,0.849,"E7449, AG.14361, PJ.34, talazoparib, olaparib, niraparib",0.202732459169284,0.0710923097560473,FALSE
+"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.237,-0.561,0.956,919,0.97,"trapidil, vatalanib, tandutinib, imatinib, crenolanib, pazopanib, regorafenib, sorafenib",0.0195421077238999,0.0132282657337552,FALSE
+"H358","Pearson.est","phosphatase inhibitor",-0.43067,-1.03,0.439,1085,0.75,"GSK2830371, alexidine, CID.5458317, mycophenolic.acid, mycophenolate.mofetil",0.357535479757879,0.1249387366083,FALSE
+"H358","Pearson.est","phosphodiesterase inhibitor",0.36231,1.04,0.399,927,0.605,"anagrelide, GSK256066, enoximone, YM.976, zardaverine, EMD.53998, cilostamide, papaverine, avanafil, trequinsin",0.399027104313252,0.218244625347531,FALSE
+"H358","Pearson.est","PI3K inhibitor",-0.36681,-0.877,0.64,786,0.842,"LY303511, BGT226, NVP.BEZ235, voxtalisib, PI3K.IN.2, buparlisib, YM.201636, CUDC.907, CH5132799, GDC.0980, alpelisib, taselisib, TG.100713, PIK.75, GSK2126458",0.193820026016113,0.0746879085003505,FALSE
+"H358","Pearson.est","PLK inhibitor",-0.55106,-1.31,0.136,910,0.533,"rigosertib, HMN.214, NMS.1286937, volasertib, BI.2536, GW.843682X",0.866461091629782,0.273272790973428,FALSE
+"H358","Pearson.est","potassium channel blocker",0.36457,1.08,0.333,210,0.587,"dofetilide, mepivacaine, meglitinide, ibutilide",0.47755576649368,0.231361898752386,FALSE
+"H358","Pearson.est","PPAR receptor agonist",-0.45252,-1.08,0.392,1089,0.715,"ciprofibrate, GW.501516, oleoylethanolamide",0.406713932979543,0.145693958198919,FALSE
+"H358","Pearson.est","progesterone receptor agonist",-0.29131,-0.702,0.85,1033,0.942,"levonorgestrel, dienogest, melengestrol.acetate",0.0705810742857073,0.0259490972071227,FALSE
+"H358","Pearson.est","proteasome inhibitor",-0.34957,-0.836,0.702,766,0.896,"ixazomib, carfilzomib, ixazomib.citrate, ONX.0914, bortezomib",0.153662887870195,0.0476919903378748,FALSE
+"H358","Pearson.est","protein synthesis inhibitor",-0.31767,-0.772,0.798,1282,0.923,"harringtonine, homoharringtonine, bruceantin, anguidine",0.0979971086492706,0.0347982989740879,FALSE
+"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.70229,-1.7,0.0128,1130,0.236,"mubritinib, AV.412, CP.724714, BMS.599626, tyrphostin.A9, NVP.TAE226",1.89279003035213,0.627087997029893,TRUE
+"H358","Pearson.est","RAF inhibitor",-0.5809,-1.38,0.0967,1069,0.484,"GDC.0879, SB.590885, PLX.4720, regorafenib, RAF265, TAK.632, sorafenib",1.014573525917,0.315154638355588,FALSE
+"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.61831,-1.47,0.0399,1185,0.374,"regorafenib, sorafenib",1.39902710431325,0.42712839779952,FALSE
+"H358","Pearson.est","retinoid receptor agonist",-0.43514,-1.04,0.435,930,0.768,"tamibarotene, CD.437, bexarotene, adarotene",0.361510743045363,0.114638779968488,FALSE
+"H358","Pearson.est","ribonucleotide reductase inhibitor",-0.39792,-0.958,0.525,733,0.832,"fludarabine.phosphate, LY2334737, clofarabine, cladribine, fludarabine",0.279840696594043,0.0798766737092761,FALSE
+"H358","Pearson.est","serotonin receptor agonist",-0.46299,-1.11,0.334,1171,0.707,"zolmitriptan, aripiprazole",0.476253533188435,0.150580586203101,FALSE
+"H358","Pearson.est","serotonin receptor antagonist",-0.52445,-1.25,0.193,954,0.573,"SB.200646, paliperidone, lurasidone, RS.16566, SB.216641, SB.228357, sertindole, aripiprazole",0.714442690992226,0.24184537803261,FALSE
+"H358","Pearson.est","sodium channel blocker",-0.41859,-1,0.465,960,0.777,"quinidine, triamterene, brivaracetam, benzethonium, A.803467, lappaconite, ajmaline",0.332547047110046,0.109578981199086,FALSE
+"H358","Pearson.est","src inhibitor",-0.25045,-0.601,0.924,1017,0.994,"ZM.306416, KX2.391, bosutinib",0.0343280287798933,0.00261361560268669,FALSE
+"H358","Pearson.est","sterol demethylase inhibitor",0.3516,1.09,0.341,941,0.625,"lanoconazole, terconazole, ketoconazole, posaconazole, sulconazole, chlormidazole",0.467245621007502,0.204119982655925,FALSE
+"H358","Pearson.est","TGF beta receptor inhibitor",-0.38895,-0.943,0.555,838,0.844,"SB.525334, SB.431542, D.4476",0.255707016877324,0.073657553374345,FALSE
+"H358","Pearson.est","thymidylate synthase inhibitor",-0.65426,-1.55,0.0313,1234,0.321,"carmofur, trifluridine, raltitrexed",1.50445566245355,0.493494967595128,FALSE
+"H358","Pearson.est","topoisomerase inhibitor",-0.35437,-0.833,0.707,684,0.884,"topotecan, valrubicin, amsacrine, beta.lapachone, camptothecin, rubitecan, etoposide, doxorubicin, irinotecan, licochalcone.a, SN.38, amonafide, TAS.103, voreloxin, idarubicin, genz.644282, exatecan.mesylate",0.150580586203101,0.0535477349869269,FALSE
+"H358","Pearson.est","tubulin polymerization inhibitor",-0.48595,-1.15,0.281,734,0.679,"BNC105, dolastatin.10, verubulin, oxibendazole, CYT.997, fenbendazole, vincristine, epothilone.b, podophyllotoxin, plinabulin, indibulin, vindesine, flubendazole, ABT.751, paclitaxel, combretastatin.A.4, KX2.391, docetaxel, vinorelbine, parbendazole, fosbretabulin, nocodazole, taltobulin, albendazole",0.55129368009492,0.168130225719498,FALSE
+"H358","Pearson.est","tyrosine kinase inhibitor",-0.49583,-1.2,0.233,1130,0.62,"mubritinib, AV.412, bafetinib, regorafenib, CP.724714, aminopurvalanol.a, BMS.599626, tivantinib, tyrphostin.A9, sorafenib, NVP.TAE226",0.632644078973981,0.207608310501746,FALSE
+"H358","Pearson.est","VEGFR inhibitor",-0.42448,-1.03,0.447,1114,0.75,"AEE788, BMS.690514, ENMD.2076, pazopanib, regorafenib, lucitanib, RAF265, golvatinib, XL.647, sorafenib, OSI.930",0.349692476868064,0.1249387366083,FALSE
+"H358","Pearson.est","vitamin D receptor agonist",-0.63843,-1.52,0.0408,1122,0.343,"maxacalcitol, paricalcitol, ercalcitriol, doxercalciferol, tacalcitol",1.38933983691012,0.464705879957229,FALSE
+"H1650","Pearson.est","EGFR inhibitor",0.27961,0.678,0.864,611,0.971,"CUDC.101, tucatinib, CP.724714, AST.1306, afatinib, WZ.4002, neratinib, BIBU.1361, osimertinib, GW.583340, WZ.3146, poziotinib, dacomitinib, ARRY.334543, AEE788, AZD8931, XL.647, dovitinib, BMS.690514, pelitinib, lapatinib",0.0634862575211067,0.0127807700919951,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",-0.39089,-1.07,0.36,1151,0.582,"nilotinib, ZM.306416, metatinib, ponatinib, GZD824, dasatinib",0.443697499232713,0.235077015350112,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.26352,0.631,0.898,711,0.982,"pilocarpine, xanomeline, nefiracetam, oxiracetam",0.0467236633326956,0.00788851221305034,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",0.3486,0.839,0.65,150,0.938,"diphemanil",0.187086643357144,0.0277971616209356,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",0.39051,0.951,0.537,406,0.841,"CGS.15943, SCH.58261, MRS.1220",0.270025714300444,0.0752040042020878,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.25463,-0.685,0.854,1080,0.91,"epinephrine, terbutaline, isoxsuprine, methyldopa, oxymetazoline, xylazine",0.068542129310995,0.0409586076789064,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.38886,0.934,0.539,324,0.828,"oxprenolol, atipamezole, atenolol......, prazosin, RS.17053, dronedarone",0.268411234813261,0.0819696632151199,FALSE
+"H1650","Pearson.est","AKT inhibitor",0.56994,1.34,0.147,160,0.525,"uprosertib, A.674563, GDC.0068, GSK2110183",0.832682665251824,0.279840696594043,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.26305,-0.71,0.776,378,0.915,"DMH1, CEP.37440, alectinib, NVP.TAE684, AZD3463, crizotinib, SB.505124, brigatinib, lorlatinib, AP26113, GW.788388",0.110138278741812,0.0385789059335517,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.44844,-1.26,0.194,1034,0.452,"enzalutamide, cyproterone.acetate, bicalutamide, RU.58841",0.712198270069774,0.344861565188618,FALSE
+"H1650","Pearson.est","antioxidant",-0.69187,-1.88,0.0139,1084,0.119,"chlorogenic.acid, mesna, rutin",1.8569851997459,0.924453038607469,TRUE
+"H1650","Pearson.est","AP inhibitor",-0.68725,-1.93,0.0171,1234,0.12,"LCL.161, birinapant, idronoxil, GDC.0152",1.76700388960785,0.920818753952375,TRUE
+"H1650","Pearson.est","ATPase inhibitor",-0.42249,-1.14,0.29,1337,0.507,"digitoxigenin, digitoxin, ouabain, k.strophanthidin",0.537602002101044,0.294992040666664,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.72764,1.77,0.0098,279,0.203,"SNS.314, ZM.447439, barasertib.HQPA, barasertib, CCT137690, AT.9283, alisertib, AMG900, PHA.680632, hesperadin, danusertib, MK.8745, PF.03814735, tozasertib, GSK1070916, TAK.901, aurora.a.inhibitor.i",2.00877392430751,0.692503962086787,TRUE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.43339,1.05,0.388,562,0.775,"azithromycin, valnemulin, azalomycin.b, tilmicosin, josamycin",0.411168274405793,0.11069829749369,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.38463,0.927,0.547,523,0.821,"nadifloxacin, norfloxacin, lomefloxacin, novobiocin",0.262012673666569,0.0856568428805592,FALSE
+"H1650","Pearson.est","BCL inhibitor",0.50328,1.25,0.208,294,0.554,"gossypol, TW.37, oridonin, ABT.737",0.681936665037238,0.25649023527157,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",-0.40312,-1.14,0.294,1151,0.507,"nilotinib, metatinib, ponatinib, GZD824, dasatinib",0.531652669587843,0.294992040666664,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",0.257,0.612,0.911,412,0.963,"piperazine, ivermectin, zaleplon, ZK.93423",0.0404816230270017,0.0163737128754655,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.98544,2.39,0,27,0,"I.BET151, OTX015, JQ1...., I.BET.762, PFI.1, bromosporine",Inf,Inf,TRUE
+"H1650","Pearson.est","calcium channel blocker",0.43501,1.04,0.43,686,0.773,"carboxyamidotriazole, SR.33805, fendiline, pranidipine, mibefradil, penfluridol, cinnarazine, tetrandrine, SKF.96365",0.366531544420413,0.111820506081675,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",0.60799,1.48,0.0739,123,0.422,"PF.04136309, SB.225002, ZK811752",1.13135556160517,0.374687549038326,FALSE
+"H1650","Pearson.est","CDK inhibitor",0.62282,1.5,0.0705,192,0.471,"indisulam, TG.02, JNJ.7706621, palbociclib, ribociclib, BMS.265246, BMS.387032, abemaciclib, R547, arcyriaflavin.a, AZD5438",1.1518108830086,0.326979092871104,FALSE
+"H1650","Pearson.est","CHK inhibitor",-0.55109,-1.54,0.0623,1254,0.218,"AZD7762, LY2606368, SCH.900776",1.20551195334083,0.661543506395395,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",0.24702,0.587,0.919,427,0.966,"naproxen, FR.122047, piroxicam, curcumin, tepoxalin, aspirin, ramifenazone, phenazone",0.0366844886138887,0.0150228735845067,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",-0.66477,-1.77,0.0213,1271,0.153,"clotrimazole, metyrapone, eplerenone, itraconazole",1.67162039656126,0.815308569182401,TRUE
+"H1650","Pearson.est","DNA alkylating agent",0.47236,1.13,0.302,184,0.767,"melphalan, mitomycin.c, TH.302, satraplatin",0.519993057042849,0.115204636051019,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.38923,0.922,0.546,326,0.81,"melphalan, chlorambucil, oxaliplatin, mechlorethamine, pibenzimol, primaquine",0.262807357295263,0.0915149811213502,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.68094,1.64,0.0331,260,0.398,"fdcyd, azacitidine, SGI.1027",1.48017200622428,0.400116927926312,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",0.23963,0.579,0.945,565,0.954,"trifluridine, cephalomannine, idoxuridine, adefovir.dipivoxil",0.0245681914907371,0.0204516252959049,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",0.33975,0.804,0.721,290,0.914,"mitomycin.c, anisomycin, floxuridine, cyclocytidine",0.142064735280571,0.0390538042661686,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",0.31405,0.748,0.771,88,0.957,"sertindole, lurasidone",0.112945621949043,0.0190880622231565,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",-0.32153,-0.895,0.564,463,0.733,"levonorgestrel, estradiol, erteberel, equol, PPT, estrone, ethinyl.estradiol, estradiol.cypionate",0.248720896016658,0.134896025358872,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",0.28199,0.679,0.843,484,0.989,"clomifene, fulvestrant, toremifene",0.0741724253752577,0.0048037084028206,FALSE
+"H1650","Pearson.est","FGFR inhibitor",-0.36651,-1,0.405,1114,0.62,"lenvatinib, orantinib, erdafitinib, MK.2461, AZD4547",0.392544976785331,0.207608310501746,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.52796,1.27,0.192,264,0.564,"TG.101348, TG.02, sorafenib, pacritinib, tozasertib, quizartinib",0.71669877129645,0.248720896016658,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",0.26196,0.619,0.895,459,0.974,"deflazacort, betamethasone, rimexolone, methylprednisolone, halobetasol.propionate, fludroxycortide, prednisolone, clobetasol.propionate",0.048176964684088,0.0114410431213845,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",-0.62348,-1.73,0.0348,1222,0.157,"CPP, tiletamine, MTPG, kynurenic.acid, latrepirdine, SIB.1757, JNJ.16259685",1.45842075605342,0.804100347590766,TRUE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.54584,-1.54,0.0833,1226,0.218,"indirubin, tideglusib, CHIR.98014, TWS.119",1.07935499859321,0.661543506395395,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.48895,1.18,0.269,706,0.683,"danusertib, GW.441756, GSK1838705A, GSK1904529A, lestaurtinib, AZD3463",0.570247719997592,0.165579296318467,FALSE
+"H1650","Pearson.est","HCV inhibitor",-0.28532,-0.796,0.691,1273,0.866,"daclatasvir, narlaprevir",0.160521952625802,0.0624821079826534,FALSE
+"H1650","Pearson.est","HDAC inhibitor",0.62824,1.54,0.0542,236,0.496,"R306465, RGFP966, resminostat, M.344, chidamide, scriptaid, vorinostat, givinostat, belinostat, SB.939, nexturastat.a, AR.42, tacedinaline, PCI.24781",1.26600071346161,0.304518323509803,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",0.27764,0.665,0.88,300,0.966,"cyproheptadine, epinastine, terfenadine, pheniramine, nizatidine",0.0555173278498314,0.0150228735845067,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.80547,-2.19,0,1350,0.0514,"atorvastatin, lovastatin, fluvastatin, pitavastatin",Inf,1.28903688100472,TRUE
+"H1650","Pearson.est","HSP inhibitor",0.29315,0.715,0.817,544,0.983,"tanespimycin, NMS.E973, XL888, PU.H71, SNX.5422",0.0877779434675845,0.00744648216786438,FALSE
+"H1650","Pearson.est","JAK inhibitor",0.5452,1.31,0.167,238,0.53,"TG.101348, TG.02, AT.9283, pacritinib, LY2784544, tozasertib",0.777283528852417,0.275724130399211,FALSE
+"H1650","Pearson.est","KIT inhibitor",0.33746,0.813,0.687,507,0.919,"sorafenib, regorafenib, pazopanib, OSI.930, masitinib, vatalanib, motesanib, KI.8751",0.16304326294045,0.0366844886138887,FALSE
+"H1650","Pearson.est","MDM inhibitor",0.40484,0.976,0.481,165,0.836,"serdemetan, RITA",0.317854923626168,0.0777937225609836,FALSE
+"H1650","Pearson.est","MEK inhibitor",-0.27447,-0.745,0.749,995,0.906,"MEK162, Ro.4987655, U.0126, selumetinib, MEK1.2.inhibitor, AZD8330, PD.318088, cobimetinib, refametinib, PD.184352, TAK.733",0.125518182300534,0.0428718023231869,FALSE
+"H1650","Pearson.est","MET inhibitor",-0.64127,-1.7,0.0488,1263,0.152,"NVP.BVU972, LY2801653, PF.04217903",1.31158017799729,0.818156412055227,TRUE
+"H1650","Pearson.est","microtubule inhibitor",0.41602,1.03,0.43,255,0.77,"D.64131, vinflunine, cabazitaxel",0.366531544420413,0.113509274827518,FALSE
+"H1650","Pearson.est","mTOR inhibitor",-0.20555,-0.576,0.964,1187,0.942,"NVP.BEZ235, deforolimus, LY3023414, SB.2343, MLN0128, torin.1, sirolimus, OSI.027",0.0159229660971692,0.0259490972071227,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",0.59455,1.44,0.0741,441,0.475,"EVP4593, betulinic.acid, parthenolide...., curcumin, tyloxapol, BAY.11.7085",1.13018179202067,0.323306390375133,FALSE
+"H1650","Pearson.est","opioid receptor agonist",-0.72419,-1.97,0.0128,1248,0.144,"spiradoline, ADL5859, cebranopadol, BW.180C",1.89279003035213,0.84163750790475,TRUE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.46085,1.12,0.305,683,0.759,"talmapimod, SB.239063, SB.242235, skepinone.l, CMPD.1, VX.702",0.515700160653214,0.11975822410452,FALSE
+"H1650","Pearson.est","PARP inhibitor",0.57063,1.37,0.116,269,0.49,"niraparib, olaparib, talazoparib, PJ.34",0.935542010773082,0.309803919971486,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.23988,0.578,0.933,142,0.938,"sorafenib, regorafenib, pazopanib",0.0301183562535,0.0277971616209356,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",-0.43329,-1.15,0.269,1362,0.573,"menadione, bis.maltolato.oxovanadium.IV., BVT.948",0.570247719997592,0.24184537803261,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",-0.34379,-0.929,0.459,1369,0.707,"anagrelide, GSK256066",0.338187314462739,0.150580586203101,FALSE
+"H1650","Pearson.est","PI3K inhibitor",0.38715,0.936,0.529,259,0.847,"CUDC.907, taselisib, alpelisib, YM.201636, LY303511, PIK.75, CH5132799",0.276544327964814,0.0721165896692931,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.73954,1.77,0.00978,219,0.203,"GW.843682X, volasertib, BI.2536, NMS.1286937, HMN.214",2.0096611452124,0.692503962086787,TRUE
+"H1650","Pearson.est","potassium channel blocker",0.34578,0.825,0.673,144,0.919,"oleoylethanolamide",0.171984935776023,0.0366844886138887,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",0.3471,0.834,0.659,640,0.925,"oleoylethanolamide, GW.501516, ciprofibrate, S26948, pterostilbene",0.18111458540599,0.0338582672609674,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",-0.25154,-0.675,0.865,1194,0.884,"norethindrone, norethindrone.acetate, danazol",0.0629838925351858,0.0535477349869269,FALSE
+"H1650","Pearson.est","proteasome inhibitor",0.53184,1.28,0.174,632,0.57,"delanzomib, ONX.0914, MG.132, oprozomib, carfilzomib",0.7594507517174,0.244125144327509,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.39482,0.959,0.518,63,0.848,"azomycin..2.nitroimidazole., anguidine, bruceantin",0.285670240254767,0.0716041477432862,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.43859,1.06,0.373,477,0.808,"CP.724714, NVP.TAE226, tyrphostin.A9, mubritinib",0.428291168191312,0.0925886392254138,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.44588,1.08,0.371,256,0.821,"sorafenib, GDC.0879, regorafenib, TAK.632, PLX.4720",0.430626090384954,0.0856568428805592,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.63418,1.51,0.0499,336,0.505,"sorafenib, regorafenib, cabozantinib",1.30189945437661,0.296708621881339,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.65859,1.58,0.0292,403,0.465,"adarotene, bexarotene, fenretinide, CD.437, tamibarotene, adapalene",1.53461714855158,0.332547047110046,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.41741,1.02,0.437,478,0.768,"pentostatin, LY2334737, fludarabine, clofarabine, gemcitabine",0.359518563029578,0.114638779968488,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",0.43179,1.05,0.404,21,0.775,"aripiprazole",0.393618634889395,0.11069829749369,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",0.58268,1.4,0.134,159,0.492,"sertindole, aripiprazole, lurasidone, SB.228357",0.872895201635192,0.30803489723264,FALSE
+"H1650","Pearson.est","sodium channel blocker",0.52017,1.26,0.191,355,0.558,"benzethonium, ajmaline, butamben, quinidine, triamterene, brivaracetam",0.718966632752272,0.253365801062421,FALSE
+"H1650","Pearson.est","src inhibitor",-0.38689,-1.02,0.384,1141,0.625,"PP.1, saracatinib, ZM.306416, dasatinib",0.415668775632469,0.204119982655925,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",-0.52606,-1.46,0.0934,1174,0.26,"ketoconazole, sulconazole, terconazole, lanoconazole",1.02965312376991,0.585026652029182,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",0.33234,0.798,0.715,126,0.904,"D.4476",0.145693958198919,0.0438315695246367,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.62777,1.49,0.058,274,0.443,"raltitrexed, trifluridine, doxifluridine",1.23657200643706,0.35359627377693,FALSE
+"H1650","Pearson.est","topoisomerase inhibitor",0.5865,1.41,0.0991,453,0.51,"exatecan.mesylate, genz.644282, topotecan, irinotecan, idarubicin, rubitecan, TAS.103, dexrazoxane, etoposide.phosphate, amsacrine, epirubicin, etoposide, teniposide, daunorubicin, SN.38, doxorubicin, camptothecin, voreloxin, licochalcone.a",1.00392634551472,0.292429823902064,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.56282,1.37,0.127,566,0.49,"taltobulin, parbendazole, albendazole, combretastatin.A.4, vinorelbine, indibulin, verubulin, vincristine, KX2.391, fosbretabulin, ABT.751, oxibendazole, nocodazole, podophyllotoxin, CYT.997, paclitaxel, dolastatin.10, epothilone.b, epothilone.d, flubendazole, fenbendazole, docetaxel",0.896196279044043,0.309803919971486,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.44214,1.06,0.382,370,0.808,"sorafenib, regorafenib, CP.724714, NVP.TAE226, tivantinib, UNC2250, hypericin, bafetinib, cabozantinib, tyrphostin.A9, aminopurvalanol.a",0.417936637088291,0.0925886392254138,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.29375,0.704,0.835,608,0.977,"sorafenib, regorafenib, golvatinib, pazopanib, foretinib, OSI.930, cabozantinib, vatalanib, motesanib, KI.8751, axitinib, AEE788, XL.647, dovitinib, BMS.690514, RAF265, cediranib",0.0783135245163979,0.0101054362812269,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",0.54476,1.31,0.177,663,0.53,"tacalcitol, maxacalcitol, ercalcitriol, doxercalciferol, alfacalcidol, calcitriol, paricalcitol",0.752026733638193,0.275724130399211,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",0.18629,0.466,0.985,331,1,"tucatinib, CUDC.101, dovitinib, BMS.690514, AST.1306, poziotinib, CGP.52411, WZ.3146, CP.724714, afatinib",0.00656376950238827,0,FALSE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.50791,-1.32,0.175,1084,0.626,"KW.2449, bosutinib, ZM.306416, tozasertib, imatinib, ponatinib, dasatinib",0.756961951313706,0.20342566678957,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.29369,0.736,0.785,369,0.982,"xanomeline, pilocarpine, oxiracetam",0.105130343254747,0.00788851221305034,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.27043,-0.698,0.828,1355,0.992,"dicycloverine",0.0819696632151199,0.00348832784582135,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",-0.33171,-0.849,0.61,478,0.921,"PSB.1115, CGS.15943, MRS.1220, theophylline, sulmazole, SCH.58261, istradefylline",0.214670164989233,0.0357403698031511,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",-0.41998,-1.08,0.362,1225,0.743,"norepinephrine, A61603, epinephrine, terbutaline, isoxsuprine",0.441291429466834,0.129011186239425,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",0.54287,1.35,0.158,293,0.815,"prazosin, practolol, RS.17053, dronedarone, atenolol......, propranolol, vincamine, naftidrofuryl",0.801342913045577,0.0888423912600234,FALSE
+"HCC95","Pearson.est","AKT inhibitor",0.36819,0.923,0.54,74,1,"GSK2110183, GDC.0068",0.267606240177031,0,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.3529,-0.92,0.527,1063,0.847,"DMH1, AZD3463, crizotinib, CEP.37440, GW.788388, AP26113",0.278189384787453,0.0721165896692931,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",-0.41834,-1.08,0.357,1068,0.743,"cyproterone.acetate, bicalutamide, RU.58841",0.447331783887807,0.129011186239425,FALSE
+"HCC95","Pearson.est","antioxidant",-0.60916,-1.52,0.0795,940,0.648,"benfotiamine, chlorogenic.acid, rutin, taurine, trolox",1.09963287134353,0.188424994129407,FALSE
+"HCC95","Pearson.est","AP inhibitor",-0.54262,-1.38,0.125,987,0.56,"embelin, birinapant, idronoxil, GDC.0152, LCL.161",0.903089986991944,0.2518119729938,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",-0.41978,-1.08,0.34,1349,0.743,"digitoxigenin, k.strophanthidin, digitoxin",0.468521082957745,0.129011186239425,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",0.53293,1.31,0.163,125,0.834,"PHA.680632, alisertib, TAK.901, AT.9283, barasertib.HQPA, aurora.a.inhibitor.i, SNS.314, danusertib",0.787812395596042,0.0788339493622613,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.26684,-0.696,0.808,1059,0.966,"azithromycin, azalomycin.b, dirithromycin",0.0925886392254138,0.0150228735845067,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.36354,0.924,0.526,564,1,"norfloxacin, novobiocin, finafloxacin, sparfloxacin, sarafloxacin",0.279014255846261,0,FALSE
+"HCC95","Pearson.est","BCL inhibitor",-0.26345,-0.671,0.837,1163,0.944,"gossypol, obatoclax, HA14.1",0.07727454200674,0.025028005701931,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.49935,-1.24,0.232,1139,0.68,"bosutinib, tozasertib, imatinib, ponatinib, dasatinib",0.6345120151091,0.167491087293764,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",0.39765,1.01,0.432,404,0.979,"ZK.93423, gamma.aminobutyric.acid, CL.218872, bentazepam, zaleplon, indiplon",0.364516253185088,0.00921730819686218,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",0.80551,2.05,0,150,0.0514,"I.BET151, OTX015, I.BET.762, JQ1....",Inf,1.28903688100472,TRUE
+"HCC95","Pearson.est","calcium channel blocker",0.5954,1.47,0.108,441,0.677,"cinnarazine, fendiline, efonidipine.monoethanolate, pranidipine, SR.33805, carboxyamidotriazole",0.96657624451305,0.169411331314856,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.36689,-0.942,0.501,1445,0.875,"navarixin",0.300162274132754,0.0579919469776868,FALSE
+"HCC95","Pearson.est","CDK inhibitor",0.39878,0.998,0.447,287,0.959,"R547, BMS.387032, CR8..R., ribociclib, PHA.793887, arcyriaflavin.a, indisulam, JNJ.7706621",0.349692476868064,0.0181813928293364,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.8099,-2.13,0,1282,0.0212,"AZD7762, LY2603618, LY2606368, SCH.900776",Inf,1.67366413907125,TRUE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",0.31232,0.766,0.723,238,0.962,"naproxen, FR.122047, aspirin, piroxicam",0.140861702705469,0.0168249279621871,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",-0.48569,-1.22,0.234,979,0.625,"metyrapone, itraconazole, PF.4981517, eplerenone, clotrimazole",0.630784142589857,0.204119982655925,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.20611,-0.526,0.967,1050,0.968,"estramustine, carboplatin, carmustine, streptozotocin",0.0145735259169983,0.0141246426916063,FALSE
+"HCC95","Pearson.est","DNA inhibitor",0.27738,0.699,0.832,149,0.952,"busulfan, tirapazamine, oxaliplatin",0.0798766737092761,0.0213630516155257,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",0.42579,1.06,0.373,9,0.905,"SGI.1027",0.428291168191312,0.0433514207947967,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",0.42679,1.06,0.393,208,0.905,"trifluridine, cephalomannine, cidofovir",0.405607449624573,0.0433514207947967,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.26535,-0.674,0.83,1436,0.968,"altretamine",0.0809219076239261,0.0141246426916063,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",0.34623,0.892,0.584,235,1,"sertindole, isofloxythepin, domperidone, clebopride, lurasidone",0.233587152887601,0,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.38852,-1.01,0.425,1106,0.81,"estrone, PPT, estradiol",0.371611069949688,0.0915149811213502,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",0.51276,1.29,0.189,167,0.803,"clomifene, tamoxifen",0.723538195826756,0.095284454721319,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",-0.49314,-1.28,0.168,1121,0.652,"erdafitinib, MK.2461, lucitanib, nintedanib, AZD4547",0.774690718274137,0.18575240426808,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",0.24037,0.597,0.911,55,0.968,"TG.101348, dovitinib",0.0404816230270017,0.0141246426916063,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",0.58325,1.48,0.0948,377,0.782,"hydrocortisone, prednisolone, rimexolone, methylprednisolone, betamethasone, halcinonide, clobetasol.propionate, flumethasone.pivalate, dexamethasone.acetate, deflazacort, desonide, ciclesonide, difluprednate, halobetasol.propionate",1.02319166266193,0.106793246940152,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",0.34743,0.879,0.587,256,1,"ACDPP, felbamate, latrepirdine, IEM1754, CPP",0.231361898752386,0,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",-0.54739,-1.41,0.143,1135,0.56,"LY2090314, tideglusib, AZD2858, indirubin",0.844663962534938,0.2518119729938,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.24518,-0.613,0.915,1116,0.957,"AZD3463, PHA.848125, GSK1838705A",0.0385789059335517,0.0190880622231565,FALSE
+"HCC95","Pearson.est","HCV inhibitor",-0.426,-1.1,0.347,1303,0.834,"narlaprevir, Ro.9187",0.459670525209126,0.0788339493622613,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.38802,-0.998,0.431,1181,0.796,"tacedinaline, JNJ.26481585, panobinostat, trichostatin.a, mocetinostat, entinostat, PCI.24781, RG2833, dacinostat",0.365522729839268,0.0990869322623309,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",0.27106,0.673,0.867,180,0.937,"chloropyramine, epinastine, levocetirizine, ICI.162846",0.0619809025237897,0.0282604091122217,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",-0.56952,-1.47,0.0857,1154,0.677,"lovastatin, fluvastatin, pitavastatin",1.0670191780768,0.169411331314856,FALSE
+"HCC95","Pearson.est","HSP inhibitor",-0.30681,-0.772,0.723,1405,0.932,"NVP.AUY922, ganetespib",0.140861702705469,0.0305840876460186,FALSE
+"HCC95","Pearson.est","JAK inhibitor",0.2812,0.685,0.817,93,0.946,"TG.101348, AT.9283",0.0877779434675845,0.0241088635982073,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.25003,-0.641,0.896,1392,0.955,"dasatinib, telatinib",0.0476919903378748,0.0199966284162537,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.77867,2,0.0038,161,0.049,"nutlin.3, idasanutlin, CGM097, AMG.232",2.42021640338319,1.30980391997149,TRUE
+"HCC95","Pearson.est","MEK inhibitor",-0.3617,-0.908,0.544,1166,0.839,"MEK162, BIX.02188, cobimetinib, TAK.733, PD.184352, nobiletin",0.26440110030182,0.0762380391712997,FALSE
+"HCC95","Pearson.est","MET inhibitor",-0.84035,-2.2,0,1380,0.0155,"PF.04217903, NVP.BVU972, PHA.665752, LY2801653",Inf,1.80966830182971,TRUE
+"HCC95","Pearson.est","microtubule inhibitor",0.28408,0.71,0.798,495,0.991,"triclabendazole, colchicine, D.64131, cytochalasin.b, cabazitaxel",0.0979971086492706,0.00392634551472468,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",0.15504,0.388,1,435,0.999,"PF.05212384, PI.103, WYE.125132, PKI.179, PP242, AZD8055, everolimus, voxtalisib",0,0.000434511774017692,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",0.30705,0.789,0.723,141,1,"EVP4593, IKK.2.inhibitor.V",0.140861702705469,0,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",-0.55585,-1.42,0.121,1067,0.695,"cebranopadol, trimebutine, BW.180C, ADL5859",0.91721462968355,0.158015195409886,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",0.5991,1.53,0.0812,291,0.768,"SB.239063, CMPD.1, SB.242235",1.09044397075882,0.114638779968488,FALSE
+"HCC95","Pearson.est","PARP inhibitor",0.41993,1.06,0.394,272,0.905,"AG.14361, niraparib, PJ.34",0.404503778174426,0.0433514207947967,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.36313,-0.932,0.539,1217,0.859,"imatinib, CP.673451, ponatinib, nintedanib, dasatinib, telatinib",0.268411234813261,0.0660068361687577,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",-0.41223,-1.04,0.401,1400,0.786,"bis.maltolato.oxovanadium.IV., BVT.948",0.396855627379818,0.104577453960592,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",-0.60652,-1.55,0.0679,1428,0.715,"GSK256066, YM.976",1.1681302257195,0.145693958198919,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",0.27659,0.708,0.822,359,0.966,"AZD6482, PF.05212384, PI.103, PIK.75, taselisib, PI.828, buparlisib, PKI.179, CUDC.907",0.0851281824599496,0.0150228735845067,FALSE
+"HCC95","Pearson.est","PLK inhibitor",0.44802,1.13,0.33,80,0.893,"HMN.214, GW.843682X",0.481486060122112,0.0491485411114536,FALSE
+"HCC95","Pearson.est","potassium channel blocker",-0.62441,-1.56,0.0658,1415,0.917,"mepivacaine",1.18177410638604,0.0376306643299789,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.34245,0.871,0.602,510,0.957,"GW.501516, ciprofibrate, pterostilbene, S26948",0.220403508742175,0.0190880622231565,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",-0.31095,-0.794,0.697,1038,0.958,"nomegestrol.acetate, dienogest, danazol, norethindrone.acetate",0.156767221901991,0.0186344909214556,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",0.33787,0.847,0.654,296,0.936,"MG.132, delanzomib, ONX.0914",0.184422251675733,0.0287241512618947,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",0.34499,0.889,0.571,303,1,"azomycin..2.nitroimidazole., clofoctol, harringtonine, bruceantin, puromycin, florfenicol",0.243363891754152,0,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.31179,-0.788,0.671,1004,0.936,"NVP.TAE226, rheochrysidin, PP.121, AV.412, BMS.599626",0.173277479831008,0.0287241512618947,FALSE
+"HCC95","Pearson.est","RAF inhibitor",0.31435,0.786,0.713,488,0.987,"PLX.4720, GDC.0879, dabrafenib, sorafenib, SB.590885",0.146910470148134,0.00568284733036327,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.32668,-0.842,0.594,1378,0.9,"vandetanib",0.226213555018806,0.0457574905606751,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",0.45884,1.16,0.283,349,0.941,"bexarotene, adarotene, adapalene, CD.437",0.54821356447571,0.0264103765727431,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.30625,0.768,0.751,19,0.988,"cytarabine",0.124360062995832,0.00524305541237188,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.48333,-1.23,0.229,1127,0.649,"zolmitriptan, NAN.190",0.640164517660112,0.187755303199631,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",0.48537,1.22,0.211,235,0.85,"sertindole, SB.228357, lurasidone",0.675717544702307,0.0705810742857073,FALSE
+"HCC95","Pearson.est","sodium channel blocker",0.5049,1.27,0.187,319,0.782,"benzethonium, brivaracetam, benzocaine, oxcarbazepine, ajmaline, A.803467, cibenzoline",0.728158393463501,0.106793246940152,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.54015,-1.41,0.112,1102,0.56,"PP.2, bosutinib, ZM.306416, dasatinib, PP.1",0.950781977329818,0.2518119729938,FALSE
+"HCC95","Pearson.est","sterol demethylase inhibitor",0.57416,1.43,0.108,181,0.69,"chlormidazole, posaconazole, sulconazole",0.96657624451305,0.161150909262745,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",0.62892,1.59,0.0499,227,0.759,"SB.525334, D.4476",1.30189945437661,0.11975822410452,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",0.351,0.878,0.605,110,0.978,"trifluridine",0.218244625347531,0.00966114521239857,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",0.25725,0.651,0.863,395,0.938,"epirubicin, etoposide.phosphate, amonafide, idarubicin, teniposide, doxorubicin, voreloxin, dexrazoxane",0.0639892042847904,0.0277971616209356,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",0.45845,1.13,0.319,372,0.893,"oxibendazole, indibulin, vincristine, parbendazole, ABT.751, flubendazole, combretastatin.A.4, taltobulin, mebendazole, vinorelbine, epothilone.b, KX2.391, dolastatin.10",0.496209316942819,0.0491485411114536,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.23557,-0.587,0.916,1360,0.954,"AMG.208, vandetanib, dasatinib",0.0381045263321496,0.0204516252959049,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.30163,-0.761,0.741,1192,0.922,"ZM.306416, MK.2461, foretinib, lucitanib, ENMD.2076, nintedanib, vandetanib, semaxanib, telatinib",0.130181792020672,0.0352690789463706,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",0.33743,0.867,0.597,572,0.931,"calcitriol, paricalcitol, maxacalcitol, ercalcitriol, doxercalciferol",0.224025668870631,0.0310503190186574,FALSE
+"H3255","Pearson.est","EGFR inhibitor",0.51456,1.28,0.167,526,0.49,"tucatinib, CUDC.101, AST.1306, lapatinib, CP.724714, ARRY.334543, WZ.4002, poziotinib, TAK.285, BMS.690514, AZD8931, BMS.599626, neratinib, canertinib, GW.583340, afatinib, osimertinib, BIBX.1382, PD.153035, dacomitinib, AEE788, CNX.2006, gefitinib, XL.647, OSI.420, rociletinib, dovitinib, BIBU.1361",0.777283528852417,0.309803919971486,FALSE
+"H3255","Pearson.est","Abl kinase inhibitor",-0.27674,-0.779,0.728,1447,0.85,"dasatinib",0.137868620686963,0.0705810742857073,FALSE
+"H3255","Pearson.est","acetylcholine receptor agonist",-0.32775,-0.912,0.537,1303,0.76,"tremorine, nicotine",0.270025714300444,0.119186407719209,FALSE
+"H3255","Pearson.est","acetylcholine receptor antagonist",-0.55528,-1.59,0.0528,1204,0.283,"methscopolamine, iododexetimide, dicycloverine",1.27736607746619,0.54821356447571,FALSE
+"H3255","Pearson.est","adenosine receptor antagonist",0.70801,1.75,0.00809,48,0.122,"CGS.15943, MRS.1220",2.09205147838773,0.913640169325252,TRUE
+"H3255","Pearson.est","adrenergic receptor agonist",-0.4856,-1.38,0.134,1281,0.293,"xylazine, oxymetazoline, A61603, terbutaline, epinephrine",0.872895201635192,0.533132379645891,FALSE
+"H3255","Pearson.est","adrenergic receptor antagonist",0.24748,0.605,0.926,88,0.954,"practolol, prazosin",0.0333890133180656,0.0204516252959049,FALSE
+"H3255","Pearson.est","AKT inhibitor",0.63028,1.55,0.0408,351,0.287,"uprosertib, GDC.0068, GSK2110183, A.674563, triciribine, AZD5363, ONC201",1.38933983691012,0.542118103266008,FALSE
+"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.32297,0.801,0.719,328,0.8,"SB.505124, crizotinib, AZD3463, DMH1",0.143271109617117,0.0969100130080564,FALSE
+"H3255","Pearson.est","androgen receptor antagonist",-0.75073,-2.16,0.00386,1138,0.0519,"nilutamide, bicalutamide, flutamide, RU.58841, enzalutamide",2.41341269532824,1.28483264215154,TRUE
+"H3255","Pearson.est","antioxidant",-0.4889,-1.37,0.156,705,0.261,"taurine, chlorogenic.acid, trolox, rutin, benfotiamine, mesna",0.806875401645538,0.583359492661719,FALSE
+"H3255","Pearson.est","AP inhibitor",-0.48234,-1.37,0.165,1213,0.261,"LCL.161, birinapant, idronoxil, GDC.0152",0.782516055786094,0.583359492661719,FALSE
+"H3255","Pearson.est","ATPase inhibitor",0.40255,0.972,0.509,263,0.735,"oligomycin.a, evodiamine, NMS.873, digoxin",0.293282217663241,0.133712660915805,FALSE
+"H3255","Pearson.est","Aurora kinase inhibitor",0.65923,1.62,0.0231,402,0.267,"PHA.680632, AT.9283, aurora.a.inhibitor.i, CCT137690, TAK.901, SNS.314, barasertib.HQPA, AMG900, alisertib, barasertib, danusertib, CCT129202, ZM.447439, GSK1070916, hesperadin, MK.8745, PF.03814735, MK.5108",1.63638802010786,0.573488738635425,FALSE
+"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.34772,0.859,0.628,158,0.78,"valnemulin, radezolid",0.202040356262804,0.10790539730952,FALSE
+"H3255","Pearson.est","bacterial DNA gyrase inhibitor",-0.47972,-1.35,0.106,1365,0.26,"lomefloxacin, sparfloxacin",0.97469413473523,0.585026652029182,FALSE
+"H3255","Pearson.est","BCL inhibitor",0.43439,1.07,0.39,569,0.671,"venetoclax, obatoclax, TW.37, ABT.737, gossypol",0.408935392973501,0.173277479831008,FALSE
+"H3255","Pearson.est","Bcr.Abl kinase inhibitor",-0.32988,-0.929,0.511,1447,0.77,"dasatinib",0.291579099865287,0.113509274827518,FALSE
+"H3255","Pearson.est","benzodiazepine receptor agonist",0.3559,0.863,0.639,437,0.792,"ZK.93423, ivermectin, zaleplon, piperazine",0.1944991418416,0.101274818410506,FALSE
+"H3255","Pearson.est","bromodomain inhibitor",0.77046,1.89,0.00543,337,0.154,"I.BET151, JQ1...., OTX015, I.BET.762, bromosporine, PFI.1",2.26520017041115,0.812479279163537,TRUE
+"H3255","Pearson.est","calcium channel blocker",0.51751,1.27,0.181,589,0.466,"carboxyamidotriazole, cinnarazine, SR.33805, penfluridol, mibefradil, pranidipine, fendiline",0.742321425130815,0.33161408331,FALSE
+"H3255","Pearson.est","CC chemokine receptor antagonist",0.63266,1.54,0.05,101,0.274,"ZK811752, SB.225002",1.30102999566398,0.562249437179612,FALSE
+"H3255","Pearson.est","CDK inhibitor",0.59661,1.44,0.0895,355,0.351,"arcyriaflavin.a, R547, indisulam, dinaciclib, BMS.387032, PHA.793887, TG.02, JNJ.7706621, kenpaullone, ribociclib, AT.7519, palbociclib, BMS.265246",1.04817696468409,0.454692883534176,FALSE
+"H3255","Pearson.est","CHK inhibitor",-0.51695,-1.45,0.104,1240,0.281,"AZD7762, LY2606368, SCH.900776",0.98296666070122,0.55129368009492,FALSE
+"H3255","Pearson.est","cyclooxygenase inhibitor",0.19921,0.492,0.981,645,0.997,"aspirin, tryptanthrin, ramifenazone, naproxen, FR.122047, phenazone, ketoprofen, pterostilbene, piroxicam, amfenac",0.0083309926200515,0.00130484168834428,FALSE
+"H3255","Pearson.est","cytochrome P450 inhibitor",-0.75549,-2.11,0,1203,0.047,"metyrapone, morin, PF.4981517, clotrimazole, eplerenone, itraconazole",Inf,1.32790214206428,TRUE
+"H3255","Pearson.est","DNA alkylating agent",0.33603,0.813,0.702,33,0.799,"TH.302, mitomycin.c",0.153662887870195,0.0974532206860086,FALSE
+"H3255","Pearson.est","DNA inhibitor",0.31666,0.776,0.732,46,0.819,"primaquine, oxaliplatin",0.135488918941608,0.0867160982395816,FALSE
+"H3255","Pearson.est","DNA methyltransferase inhibitor",0.72969,1.78,0.00938,201,0.116,"fdcyd, SGI.1027, azacitidine",2.02779716162094,0.935542010773082,TRUE
+"H3255","Pearson.est","DNA polymerase inhibitor",0.4636,1.16,0.28,199,0.578,"trifluridine, idoxuridine, cephalomannine",0.552841968657781,0.238072161579471,FALSE
+"H3255","Pearson.est","DNA synthesis inhibitor",0.44009,1.06,0.396,298,0.669,"mitomycin.c, cyclocytidine, anisomycin, floxuridine, artesunate, enocitabine",0.402304814074488,0.174573882232177,FALSE
+"H3255","Pearson.est","dopamine receptor antagonist",0.29631,0.723,0.814,56,0.853,"sertindole, lurasidone",0.0893755951107988,0.069050968832477,FALSE
+"H3255","Pearson.est","estrogen receptor agonist",-0.47711,-1.33,0.155,1131,0.259,"levonorgestrel, PPT, estradiol, estradiol.cypionate",0.809668301829709,0.586700235918748,FALSE
+"H3255","Pearson.est","estrogen receptor antagonist",0.47823,1.15,0.285,176,0.578,"clomifene, fulvestrant",0.54515513999149,0.238072161579471,FALSE
+"H3255","Pearson.est","FGFR inhibitor",-0.15446,-0.442,0.992,1375,0.995,"AZD4547",0.00348832784582135,0.00217691925427455,FALSE
+"H3255","Pearson.est","FLT3 inhibitor",0.36379,0.894,0.585,601,0.777,"sorafenib, pacritinib, quizartinib, TG.02, GTP.14564, TG.101348, lestaurtinib, sunitinib, KW.2449, dovitinib, tozasertib, tandutinib",0.23284413391782,0.109578981199086,FALSE
+"H3255","Pearson.est","glucocorticoid receptor agonist",-0.16725,-0.466,0.989,238,1,"rimexolone, methylprednisolone, deflazacort, prednisolone, betamethasone, halobetasol.propionate, clobetasol.propionate, fluticasone.propionate, prednisolone.hemisuccinate, flumethasone, triamcinolone.acetonide, halcinonide, beclomethasone.dipropionate, difluprednate, desonide, ciclesonide, flumethasone.pivalate, fluorometholone, triamcinolone, piretanide, fludroxycortide, hydrocortisone, dexamethasone.acetate, fluocinolone.acetonide, prednisolone.acetate",0.0048037084028206,0,FALSE
+"H3255","Pearson.est","glutamate receptor antagonist",-0.28281,-0.794,0.703,1202,0.863,"CGP.37849, diazooxonorleucine, kynurenic.acid, SIB.1757, JNJ.16259685",0.153044674980176,0.0639892042847904,FALSE
+"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.28728,-0.827,0.651,1109,0.843,"LY2090314, CHIR.99021, tideglusib, CHIR.98014",0.186419011431808,0.0741724253752577,FALSE
+"H3255","Pearson.est","growth factor receptor inhibitor",0.65245,1.58,0.0344,366,0.3,"danusertib, GW.441756, AZD3463, lestaurtinib",1.46344155742847,0.522878745280338,FALSE
+"H3255","Pearson.est","HCV inhibitor",0.50366,1.22,0.231,618,0.522,"PSI.7976, embelin, daclatasvir",0.636388020107856,0.282329496997738,FALSE
+"H3255","Pearson.est","HDAC inhibitor",0.56122,1.4,0.0886,359,0.376,"M.344, scriptaid, givinostat, vorinostat, R306465, ACY.1215, AR.42, dacinostat, resminostat, RGFP966, trichostatin.a, PCI.24781, SB.939, romidepsin, belinostat",1.05256627811295,0.424812155072339,FALSE
+"H3255","Pearson.est","histamine receptor antagonist",-0.17573,-0.492,0.968,621,1,"tiotidine, terfenadine, ICI.162846, tecastemizole, BF2.649, astemizole, nizatidine, cyproheptadine, cimetidine, pheniramine, ebastine, ranitidine, famotidine, zolantidine, chloropyramine, lafutidine",0.0141246426916063,0,FALSE
+"H3255","Pearson.est","HMGCR inhibitor",-0.86477,-2.42,0,1247,0.0128,"simvastatin, lovastatin, atorvastatin, mevastatin, pitavastatin, fluvastatin",Inf,1.89279003035213,TRUE
+"H3255","Pearson.est","HSP inhibitor",0.45141,1.11,0.344,674,0.634,"tanespimycin, XL888, NMS.E973, VER.49009, alvespimycin, KW.2478, NVP.AUY922, SNX.5422",0.46344155742847,0.197910742118267,FALSE
+"H3255","Pearson.est","JAK inhibitor",0.36756,0.899,0.588,366,0.786,"AT.9283, pacritinib, TG.02, AZ960, TG.101348, lestaurtinib",0.230622673923862,0.104577453960592,FALSE
+"H3255","Pearson.est","KIT inhibitor",0.37473,0.917,0.555,348,0.795,"sorafenib, pazopanib, regorafenib, OSI.930, vatalanib, imatinib, motesanib, masitinib",0.255707016877324,0.0996328713435297,FALSE
+"H3255","Pearson.est","MDM inhibitor",0.5719,1.41,0.0951,583,0.381,"nutlin.3, RITA, CGM097, serdemetan, idasanutlin",1.02181948306259,0.419075024324381,FALSE
+"H3255","Pearson.est","MEK inhibitor",0.15678,0.378,0.996,756,0.998,"arctigenin, PD.0325901, trametinib, U.0126, PD.198306, selumetinib, AZD8330, AS.703026",0.00174066157630127,0.000869458712628891,FALSE
+"H3255","Pearson.est","MET inhibitor",-0.65234,-1.91,0.0266,1351,0.115,"LY2801653, PF.04217903, PHA.665752",1.57511836336893,0.939302159646388,TRUE
+"H3255","Pearson.est","microtubule inhibitor",0.41436,1.04,0.42,410,0.686,"D.64131, vinflunine, podophyllotoxin, cabazitaxel, triclabendazole",0.3767507096021,0.163675884293248,FALSE
+"H3255","Pearson.est","mTOR inhibitor",0.57528,1.39,0.127,380,0.371,"PF.05212384, WYE.125132, GSK2126458, PKI.179, AZD8055, AZD2014, MLN0128, everolimus, PI.103, sirolimus, GDC.0980, torin.2, XL388, PP242, torin.1, deforolimus, voxtalisib, NVP.BEZ235, temsirolimus",0.896196279044043,0.430626090384954,FALSE
+"H3255","Pearson.est","NFkB pathway inhibitor",0.34847,0.844,0.657,1,0.786,"EVP4593",0.182434630440219,0.104577453960592,FALSE
+"H3255","Pearson.est","opioid receptor agonist",-0.44346,-1.26,0.174,1436,0.304,"BW.180C",0.7594507517174,0.517126416391246,FALSE
+"H3255","Pearson.est","p38 MAPK inhibitor",0.36204,0.882,0.61,221,0.778,"skepinone.l, SB.239063",0.214670164989233,0.109020403010311,FALSE
+"H3255","Pearson.est","PARP inhibitor",0.4185,1.02,0.415,606,0.686,"niraparib, PJ.34, AG.14361, AZD2461, talazoparib",0.381951903287907,0.163675884293248,FALSE
+"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.31204,0.761,0.758,363,0.823,"sorafenib, pazopanib, regorafenib, vatalanib, imatinib, trapidil, motesanib, masitinib, axitinib",0.120330794367946,0.0846001647877302,FALSE
+"H3255","Pearson.est","phosphatase inhibitor",0.37289,0.91,0.577,399,0.787,"mycophenolate.mofetil, mycophenolic.acid, CID.5458317, GSK2830371, alexidine",0.238824186844269,0.104025267640935,FALSE
+"H3255","Pearson.est","phosphodiesterase inhibitor",-0.52322,-1.48,0.0969,1038,0.314,"enoximone, papaverine, anagrelide, GSK256066, YM.976",1.01367622294923,0.503070351926785,FALSE
+"H3255","Pearson.est","PI3K inhibitor",0.51742,1.27,0.19,500,0.466,"PF.05212384, GSK2126458, PKI.179, taselisib, CUDC.907, buparlisib, CH5132799, PI.103, GDC.0980, alpelisib, BGT226, PIK.75, voxtalisib, NVP.BEZ235, YM.201636, TG.100713, PI3K.IN.2, SB.2343, LY3023414",0.721246399047171,0.33161408331,FALSE
+"H3255","Pearson.est","PLK inhibitor",0.75528,1.86,0.00266,229,0.104,"GW.843682X, NMS.1286937, HMN.214, volasertib, GSK461364, BI.2536",2.57511836336893,0.98296666070122,TRUE
+"H3255","Pearson.est","potassium channel blocker",-0.63349,-1.79,0.0263,1205,0.158,"dofetilide, mepivacaine, ibutilide, meglitinide",1.58004425151024,0.801342913045577,TRUE
+"H3255","Pearson.est","PPAR receptor agonist",-0.29676,-0.872,0.631,1404,0.797,"clofibrate",0.199970640755866,0.0985416786038876,FALSE
+"H3255","Pearson.est","progesterone receptor agonist",-0.50956,-1.45,0.114,1253,0.281,"nomegestrol.acetate, dienogest, danazol, norethindrone.acetate",0.943095148663527,0.55129368009492,FALSE
+"H3255","Pearson.est","proteasome inhibitor",0.48433,1.18,0.282,745,0.56,"ONX.0914, carfilzomib, MG.132, delanzomib, bortezomib, ixazomib.citrate, ixazomib",0.549750891680639,0.2518119729938,FALSE
+"H3255","Pearson.est","protein synthesis inhibitor",0.62978,1.53,0.0509,290,0.266,"bruceantin, harringtonine, anguidine, azomycin..2.nitroimidazole., homoharringtonine, thiostrepton, mercaptopurine, florfenicol, tedizolid.phosphate",1.29328221766324,0.575118363368933,FALSE
+"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.73666,1.81,0.00404,200,0.118,"mubritinib, CP.724714, tyrphostin.A9, BMS.599626, NVP.TAE226",2.3936186348894,0.928117992693875,TRUE
+"H3255","Pearson.est","RAF inhibitor",0.51326,1.25,0.215,533,0.484,"sorafenib, SB.590885, regorafenib, TAK.632, PLX.4720, RAF265, GDC.0879, CEP.32496, AZ.628",0.667561540084395,0.315154638355588,FALSE
+"H3255","Pearson.est","RET tyrosine kinase inhibitor",0.53049,1.29,0.183,571,0.493,"sorafenib, regorafenib, apatinib, sunitinib, cabozantinib",0.737548910269571,0.30715308072277,FALSE
+"H3255","Pearson.est","retinoid receptor agonist",0.56393,1.36,0.146,323,0.405,"bexarotene, fenretinide, adarotene, CD.437",0.835647144215563,0.392544976785331,FALSE
+"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.22184,-0.655,0.864,319,0.987,"cytarabine, LY2334737, gemcitabine, cladribine, fludarabine.phosphate, pentostatin, clofarabine, triapine, hydroxyurea, fludarabine",0.0634862575211067,0.00568284733036327,FALSE
+"H3255","Pearson.est","serotonin receptor agonist",-0.53133,-1.44,0.129,1350,0.265,"NAN.190, aripiprazole",0.889410289700751,0.576754126063192,FALSE
+"H3255","Pearson.est","serotonin receptor antagonist",0.39811,0.983,0.497,56,0.735,"sertindole, lurasidone",0.303643611266668,0.133712660915805,FALSE
+"H3255","Pearson.est","sodium channel blocker",0.34739,0.842,0.658,567,0.773,"ajmaline, benzethonium, brivaracetam, lappaconite, benzocaine, butamben, A.803467, quinidine, triamterene",0.181774106386044,0.111820506081675,FALSE
+"H3255","Pearson.est","src inhibitor",-0.52228,-1.48,0.0795,1258,0.314,"saracatinib, PP.1, PP.2, dasatinib",1.09963287134353,0.503070351926785,FALSE
+"H3255","Pearson.est","sterol demethylase inhibitor",0.54023,1.34,0.162,524,0.421,"chlormidazole, sulconazole, posaconazole, ketoconazole",0.790484985457369,0.375717904164332,FALSE
+"H3255","Pearson.est","TGF beta receptor inhibitor",0.48368,1.19,0.243,593,0.561,"SB.525334, adaprev, SB.431542, D.4476",0.614393726401688,0.251037138743839,FALSE
+"H3255","Pearson.est","thymidylate synthase inhibitor",0.59193,1.46,0.0716,396,0.339,"trifluridine, raltitrexed, carmofur",1.14508697769214,0.469800301796918,FALSE
+"H3255","Pearson.est","topoisomerase inhibitor",0.42811,1.07,0.381,624,0.671,"idarubicin, amonafide, TAS.103, epirubicin, SN.38, valrubicin, doxorubicin, irinotecan, genz.644282, exatecan.mesylate, etoposide.phosphate, daunorubicin, nemorubicin, amsacrine, teniposide, dexrazoxane, camptothecin, voreloxin",0.419075024324381,0.173277479831008,FALSE
+"H3255","Pearson.est","tubulin polymerization inhibitor",0.5993,1.47,0.0791,384,0.348,"albendazole, nocodazole, taltobulin, indibulin, parbendazole, flubendazole, plinabulin, epothilone.b, oxibendazole, dolastatin.10, ABT.751, docetaxel, vinorelbine, combretastatin.A.4, vincristine, KX2.391, podophyllotoxin, paclitaxel",1.10182351650232,0.458420756053419,FALSE
+"H3255","Pearson.est","tyrosine kinase inhibitor",0.42333,1.03,0.426,200,0.685,"mubritinib, bafetinib, CP.724714, tyrphostin.A9, sorafenib, regorafenib, BMS.599626, NVP.TAE226",0.370590400897281,0.164309428507574,FALSE
+"H3255","Pearson.est","VEGFR inhibitor",0.40043,0.967,0.518,523,0.725,"golvatinib, sorafenib, pazopanib, BMS.690514, foretinib, regorafenib, OSI.930, vatalanib, tivozanib, motesanib, axitinib, AEE788, ZM.306416, XL.647, RAF265, sunitinib, PD.173074, dovitinib",0.285670240254767,0.139661993429006,FALSE
+"H3255","Pearson.est","vitamin D receptor agonist",0.64784,1.57,0.04,424,0.282,"maxacalcitol, tacalcitol, paricalcitol, calcitriol, ercalcitriol, doxercalciferol",1.39794000867204,0.549750891680639,FALSE
+"H1648","Pearson.est","EGFR inhibitor",-0.22011,-0.554,0.957,1043,0.954,"PD.153035, CP.724714, tyrphostin.AG.494, pelitinib, BIBU.1361, CGP.52411, rociletinib, tyrphostin.AG.1478, erlotinib, salvianolic.acid.B, icotinib, gefitinib",0.0190880622231565,0.0204516252959049,FALSE
+"H1648","Pearson.est","Abl kinase inhibitor",-0.26095,-0.669,0.849,1038,0.901,"nilotinib, KW.2449, flumatinib, bosutinib",0.0710923097560473,0.045275209020937,FALSE
+"H1648","Pearson.est","acetylcholine receptor agonist",-0.4388,-1.1,0.333,1444,0.449,"tremorine",0.47755576649368,0.347753658996677,FALSE
+"H1648","Pearson.est","acetylcholine receptor antagonist",-0.59344,-1.51,0.0885,1304,0.291,"methscopolamine, dicycloverine",1.05305672930217,0.536107011014093,FALSE
+"H1648","Pearson.est","adenosine receptor antagonist",-0.73314,-1.87,0.00935,1408,0.335,"istradefylline, SCH.58261",2.02918838912748,0.474955192963155,FALSE
+"H1648","Pearson.est","adrenergic receptor agonist",-0.47382,-1.24,0.235,1144,0.383,"terbutaline, norepinephrine, A61603, xylazine, epinephrine, oxymetazoline, isoetharine",0.628932137728264,0.416801226031377,FALSE
+"H1648","Pearson.est","adrenergic receptor antagonist",0.29744,0.783,0.722,243,0.874,"RS.17053, prazosin, practolol, oxprenolol, dronedarone, atenolol......",0.141462802430361,0.058488567365597,FALSE
+"H1648","Pearson.est","AKT inhibitor",0.63986,1.68,0.0415,280,0.202,"GDC.0068, A.674563, GSK2110183, uprosertib, MK.2206, ONC201",1.38195190328791,0.694648630553376,TRUE
+"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.44635,1.18,0.26,387,0.499,"alectinib, AZD3463, lorlatinib, brigatinib, DMH1, SB.505124",0.585026652029182,0.30189945437661,FALSE
+"H1648","Pearson.est","androgen receptor antagonist",-0.68097,-1.72,0.0291,1248,0.193,"enzalutamide, flutamide",1.53610701101409,0.714442690992226,TRUE
+"H1648","Pearson.est","antioxidant",-0.71458,-1.82,0.0113,1052,0.163,"rutin, taurine, trolox, mesna, chlorogenic.acid",1.94692155651658,0.787812395596042,TRUE
+"H1648","Pearson.est","AP inhibitor",-0.55131,-1.39,0.13,1067,0.317,"tanshinone.i, idronoxil, LCL.161, birinapant, GDC.0152",0.886056647693163,0.498940737782249,FALSE
+"H1648","Pearson.est","ATPase inhibitor",0.29044,0.769,0.732,50,0.832,"oligomycin.a, evodiamine",0.135488918941608,0.0798766737092761,FALSE
+"H1648","Pearson.est","Aurora kinase inhibitor",0.63578,1.68,0.0335,237,0.202,"barasertib, alisertib, AT.9283, AMG900, aurora.a.inhibitor.i, TAK.901, barasertib.HQPA, ZM.447439, MK.5108, SNS.314, danusertib, PHA.680632, GSK1070916",1.47495519296315,0.694648630553376,TRUE
+"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.23403,0.615,0.923,1111,0.947,"valnemulin, tilmicosin, azalomycin.b, tedizolid, josamycin, radezolid, dirithromycin, azithromycin",0.0347982989740879,0.0236500209967266,FALSE
+"H1648","Pearson.est","bacterial DNA gyrase inhibitor",-0.42822,-1.1,0.333,1104,0.449,"sparfloxacin, lomefloxacin, finafloxacin, sarafloxacin",0.47755576649368,0.347753658996677,FALSE
+"H1648","Pearson.est","BCL inhibitor",0.45819,1.18,0.259,488,0.499,"obatoclax, TW.37, venetoclax, ABT.737, gossypol",0.586700235918748,0.30189945437661,FALSE
+"H1648","Pearson.est","Bcr.Abl kinase inhibitor",-0.28836,-0.745,0.754,1272,0.858,"flumatinib, bosutinib",0.122628654130226,0.0665127121512946,FALSE
+"H1648","Pearson.est","benzodiazepine receptor agonist",-0.26927,-0.689,0.842,943,0.905,"lorazepam, CL.218872, zaleplon, temazepam, gamma.aminobutyric.acid, piperazine",0.0746879085003505,0.0433514207947967,FALSE
+"H1648","Pearson.est","bromodomain inhibitor",0.82954,2.15,0.00204,105,0.0366,"OTX015, I.BET151, JQ1....",2.6903698325741,1.43651891460559,TRUE
+"H1648","Pearson.est","calcium channel blocker",0.5426,1.42,0.121,215,0.298,"carboxyamidotriazole, pranidipine, SR.33805, penfluridol",0.91721462968355,0.525783735923745,FALSE
+"H1648","Pearson.est","CC chemokine receptor antagonist",-0.48548,-1.24,0.217,1227,0.383,"navarixin, MK.0812, RS.504393",0.66354026615147,0.416801226031377,FALSE
+"H1648","Pearson.est","CDK inhibitor",0.50129,1.33,0.18,265,0.335,"R547, indisulam, BMS.387032, abemaciclib, ribociclib, AT.7519, palbociclib, NU6027, TG.02",0.744727494896694,0.474955192963155,FALSE
+"H1648","Pearson.est","CHK inhibitor",-0.61917,-1.58,0.0559,1039,0.263,"PF.477736, SCH.900776, AZD7762, LY2606368",1.25258819211358,0.580044251510242,FALSE
+"H1648","Pearson.est","cyclooxygenase inhibitor",-0.49702,-1.24,0.224,1171,0.383,"aspirin, ramifenazone, amfenac, indoprofen, FK.3311, FR.122047, sulfasalazine",0.649751981665837,0.416801226031377,FALSE
+"H1648","Pearson.est","cytochrome P450 inhibitor",-0.6995,-1.84,0.0157,1359,0.213,"eplerenone, morin, itraconazole",1.80410034759077,0.671620396561262,TRUE
+"H1648","Pearson.est","DNA alkylating agent",0.54777,1.4,0.133,90,0.302,"melphalan, mitomycin.c, ifosfamide, satraplatin, TH.302",0.876148359032914,0.519993057042849,FALSE
+"H1648","Pearson.est","DNA inhibitor",0.28203,0.718,0.777,182,0.847,"melphalan, sangivamycin, chlorambucil, pibenzimol",0.109578981199086,0.0721165896692931,FALSE
+"H1648","Pearson.est","DNA methyltransferase inhibitor",0.67144,1.75,0.0261,288,0.248,"fdcyd, SGI.1027, azacitidine, disulfiram",1.58335949266172,0.605548319173784,TRUE
+"H1648","Pearson.est","DNA polymerase inhibitor",0.32441,0.845,0.626,509,0.818,"cephalomannine, menadione, trifluridine, foscarnet, cidofovir, adefovir.dipivoxil",0.20342566678957,0.087246696328677,FALSE
+"H1648","Pearson.est","DNA synthesis inhibitor",0.43913,1.14,0.306,41,0.468,"mitomycin.c, floxuridine, enocitabine",0.51427857351842,0.329754146925876,FALSE
+"H1648","Pearson.est","dopamine receptor antagonist",-0.44596,-1.15,0.307,1249,0.419,"acetophenazine, remoxipride, UH.232...., thioproperazine, piperacetazine, raclopride",0.512861624522813,0.377785977033705,FALSE
+"H1648","Pearson.est","estrogen receptor agonist",-0.58593,-1.48,0.0882,1258,0.238,"ethinyl.estradiol, estradiol.cypionate, estradiol",1.05453141486818,0.623423042943488,FALSE
+"H1648","Pearson.est","estrogen receptor antagonist",-0.4644,-1.2,0.25,1203,0.394,"raloxifene, tamoxifen",0.602059991327962,0.404503778174426,FALSE
+"H1648","Pearson.est","FGFR inhibitor",0.74945,1.92,0.00622,203,0.0926,"regorafenib, dovitinib, lenvatinib, erdafitinib, AZD4547, PD.173074",2.20620961530918,1.03338901331807,TRUE
+"H1648","Pearson.est","FLT3 inhibitor",0.34092,0.903,0.56,438,0.761,"sorafenib, sunitinib, dovitinib, quizartinib, TG.02, TG.101348, pacritinib, ENMD.2076, ponatinib",0.2518119729938,0.118615343229427,FALSE
+"H1648","Pearson.est","glucocorticoid receptor agonist",-0.60544,-1.56,0.0789,966,0.258,"betamethasone, halobetasol.propionate, fluorometholone, triamcinolone, clobetasol.propionate, flumethasone, hydrocortisone, triamcinolone.acetonide, fluticasone.propionate, piretanide, rimexolone, fludroxycortide, fluocinolone.acetonide, dexamethasone.acetate, prednisolone.acetate, beclomethasone.dipropionate",1.10292299679058,0.58838029403677,FALSE
+"H1648","Pearson.est","glutamate receptor antagonist",-0.53731,-1.38,0.14,1420,0.309,"kynurenic.acid, JNJ.16259685, SIB.1757",0.853871964321762,0.510041520575165,FALSE
+"H1648","Pearson.est","glycogen synthase kinase inhibitor",-0.58545,-1.48,0.104,1099,0.238,"GSK.3.inhibitor.IX, tideglusib, TWS.119, LY2090314, indirubin",0.98296666070122,0.623423042943488,FALSE
+"H1648","Pearson.est","growth factor receptor inhibitor",0.38809,1,0.412,198,0.62,"GW.441756, AZD3463, danusertib",0.385102783966865,0.207608310501746,FALSE
+"H1648","Pearson.est","HCV inhibitor",0.31433,0.82,0.684,267,0.836,"embelin, narlaprevir",0.164943898279884,0.0777937225609836,FALSE
+"H1648","Pearson.est","HDAC inhibitor",-0.34631,-0.883,0.58,1285,0.723,"dacinostat, panobinostat, mocetinostat, trichostatin.a, nexturastat.a",0.236572006437063,0.140861702705469,FALSE
+"H1648","Pearson.est","histamine receptor antagonist",-0.5086,-1.3,0.187,903,0.364,"cimetidine, ICI.162846, tiotidine, ranitidine, BF2.649, nizatidine, terfenadine, chloropyramine, cyproheptadine, zolantidine, famotidine, lafutidine",0.728158393463501,0.438898616350944,FALSE
+"H1648","Pearson.est","HMGCR inhibitor",-0.41529,-1.05,0.393,1241,0.498,"lovastatin, fluvastatin",0.405607449624573,0.302770657240282,FALSE
+"H1648","Pearson.est","HSP inhibitor",0.27136,0.718,0.782,320,0.847,"tanespimycin, NMS.E973, KW.2478, VER.49009",0.106793246940152,0.0721165896692931,FALSE
+"H1648","Pearson.est","JAK inhibitor",-0.312,-0.798,0.687,1222,0.832,"atiprimod, CEP.33779, WHI.P154, AZD1480",0.16304326294045,0.0798766737092761,FALSE
+"H1648","Pearson.est","KIT inhibitor",0.58979,1.5,0.0785,322,0.282,"motesanib, regorafenib, sorafenib, sunitinib, pazopanib, lenvatinib, OSI.930, cediranib, imatinib",1.10513034325475,0.549750891680639,FALSE
+"H1648","Pearson.est","MDM inhibitor",0.62003,1.63,0.0474,507,0.214,"CGM097, RITA, idasanutlin, AMG.232, serdemetan",1.32422165832591,0.669586226650809,TRUE
+"H1648","Pearson.est","MEK inhibitor",-0.47003,-1.21,0.261,878,0.399,"AS.703026, PD.98059, AZD8330, cobimetinib, PD.198306, PD.0325901, selumetinib, trametinib, Ro.4987655, TAK.733, MEK162, MEK1.2.inhibitor, PD.318088, refametinib, BIX.02188, PD.184352",0.583359492661719,0.399027104313252,FALSE
+"H1648","Pearson.est","MET inhibitor",-0.6568,-1.69,0.0318,1116,0.166,"LY2801653, NVP.BVU972, PHA.665752, PF.04217903",1.49757288001557,0.779891911959945,TRUE
+"H1648","Pearson.est","microtubule inhibitor",0.31862,0.849,0.61,516,0.835,"cabazitaxel, podophyllotoxin, vinflunine, cytochalasin.b, D.64131, triclabendazole",0.214670164989233,0.0783135245163979,FALSE
+"H1648","Pearson.est","mTOR inhibitor",0.63001,1.6,0.0583,287,0.229,"PI.103, PF.05212384, GSK2126458, GDC.0980, temsirolimus, torin.2, everolimus, voxtalisib, PP242, SB.2343, MLN0128, AZD2014, LY303511, ku.0063794, torin.1, WYE.125132, OSI.027",1.23433144524099,0.640164517660112,FALSE
+"H1648","Pearson.est","NFkB pathway inhibitor",-0.30182,-0.767,0.739,922,0.853,"IKK.2.inhibitor.V, curcumin, Ro.106.9920, BAY.11.7082, tyloxapol, parthenolide",0.131355561605174,0.069050968832477,FALSE
+"H1648","Pearson.est","opioid receptor agonist",-0.71882,-1.81,0.0168,1109,0.134,"salvinorin.a, ADL5859, BW.180C, cebranopadol",1.77469071827414,0.872895201635192,TRUE
+"H1648","Pearson.est","p38 MAPK inhibitor",0.59309,1.5,0.0973,427,0.282,"VX.702, skepinone.l, CMPD.1, talmapimod, SB.239063",1.01188715973165,0.549750891680639,FALSE
+"H1648","Pearson.est","PARP inhibitor",0.45597,1.17,0.3,285,0.493,"niraparib, E7449, AZD2461, olaparib, talazoparib",0.522878745280338,0.30715308072277,FALSE
+"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.57019,1.49,0.102,137,0.26,"motesanib, regorafenib, sorafenib, trapidil, sunitinib, pazopanib, dovitinib, lenvatinib",0.991399828238082,0.585026652029182,FALSE
+"H1648","Pearson.est","phosphatase inhibitor",0.44522,1.15,0.304,155,0.487,"mycophenolate.mofetil, mycophenolic.acid, GSK2830371",0.517126416391246,0.312471038785366,FALSE
+"H1648","Pearson.est","phosphodiesterase inhibitor",-0.58585,-1.49,0.0879,1297,0.289,"GSK256066, avanafil, papaverine",1.05601112492623,0.539102157243452,FALSE
+"H1648","Pearson.est","PI3K inhibitor",0.66393,1.73,0.042,276,0.231,"PI.103, PIK.75, taselisib, PI.828, alpelisib, PF.05212384, GSK2126458, GDC.0980, buparlisib, voxtalisib, SB.2343, BGT226, YM.201636, LY303511, CUDC.907, PI3K.IN.2",1.3767507096021,0.636388020107856,TRUE
+"H1648","Pearson.est","PLK inhibitor",0.60895,1.53,0.0721,522,0.287,"NMS.1286937, GSK461364, BI.2536, volasertib, GW.843682X, HMN.214",1.14206473528057,0.542118103266008,FALSE
+"H1648","Pearson.est","potassium channel blocker",-0.43453,-1.15,0.27,1323,0.419,"meglitinide",0.568636235841013,0.377785977033705,FALSE
+"H1648","Pearson.est","PPAR receptor agonist",0.29698,0.769,0.734,521,0.832,"pterostilbene, fenofibrate, clofibrate, oleoylethanolamide",0.134303940083929,0.0798766737092761,FALSE
+"H1648","Pearson.est","progesterone receptor agonist",-0.67162,-1.69,0.0391,1084,0.166,"dienogest, norethindrone.acetate, nomegestrol.acetate, norethindrone, tanaproget, norgestrel",1.40782324260413,0.779891911959945,TRUE
+"H1648","Pearson.est","proteasome inhibitor",0.39039,1.03,0.418,405,0.59,"delanzomib, ONX.0914, MG.132",0.378823718224965,0.229147988357856,FALSE
+"H1648","Pearson.est","protein synthesis inhibitor",0.4296,1.14,0.318,121,0.468,"clofoctol, anguidine, harringtonine, azomycin..2.nitroimidazole.",0.497572880015567,0.329754146925876,FALSE
+"H1648","Pearson.est","protein tyrosine kinase inhibitor",0.2342,0.597,0.929,227,0.944,"mubritinib, tyrphostin.A9",0.0319842860063582,0.025028005701931,FALSE
+"H1648","Pearson.est","RAF inhibitor",0.54449,1.49,0.0909,143,0.26,"regorafenib, sorafenib, AZ.628",1.04143611677803,0.585026652029182,FALSE
+"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.83113,2.14,0,193,0.0189,"regorafenib, sorafenib, cabozantinib, sunitinib, apatinib",Inf,1.72353819582676,TRUE
+"H1648","Pearson.est","retinoid receptor agonist",0.76432,2.04,0.00221,221,0.0467,"adarotene, fenretinide, tamibarotene, bexarotene, AM.580, adapalene",2.65560772631489,1.33068311943389,TRUE
+"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.54349,1.42,0.0966,341,0.298,"gemcitabine, LY2334737, fludarabine.phosphate, clofarabine, cytarabine",1.01502287358451,0.525783735923745,FALSE
+"H1648","Pearson.est","serotonin receptor agonist",-0.52119,-1.35,0.175,1070,0.325,"pardoprunox, SR.57227A, zolmitriptan, NAN.190",0.756961951313706,0.488116639021126,FALSE
+"H1648","Pearson.est","serotonin receptor antagonist",0.41151,1.06,0.368,333,0.563,"sertindole, aripiprazole, ziprasidone, lurasidone",0.434152181326482,0.249491605148654,FALSE
+"H1648","Pearson.est","sodium channel blocker",0.17514,0.462,0.988,328,0.991,"brivaracetam, triamterene, benzethonium, cibenzoline",0.00524305541237188,0.00392634551472468,FALSE
+"H1648","Pearson.est","src inhibitor",-0.58395,-1.48,0.0938,1327,0.238,"bosutinib, PP.1, PP.2",1.02779716162094,0.623423042943488,FALSE
+"H1648","Pearson.est","sterol demethylase inhibitor",0.30153,0.782,0.712,359,0.853,"ketoconazole, chlormidazole, sulconazole",0.147520006363144,0.069050968832477,FALSE
+"H1648","Pearson.est","TGF beta receptor inhibitor",0.28607,0.727,0.778,515,0.874,"repsox, SB.525334, LY2109761",0.109020403010311,0.058488567365597,FALSE
+"H1648","Pearson.est","thymidylate synthase inhibitor",0.65313,1.71,0.0424,458,0.222,"raltitrexed, carmofur, trifluridine, capecitabine, doxifluridine",1.37263414340727,0.653647025549361,TRUE
+"H1648","Pearson.est","topoisomerase inhibitor",0.6411,1.64,0.0438,342,0.225,"epirubicin, nemorubicin, exatecan.mesylate, topotecan, teniposide, amsacrine, idarubicin, etoposide.phosphate, doxorubicin, rubitecan, amonafide, irinotecan, daunorubicin, TAS.103, genz.644282, dexrazoxane, SN.38, camptothecin",1.3585258894959,0.647817481888638,TRUE
+"H1648","Pearson.est","tubulin polymerization inhibitor",0.52197,1.37,0.149,388,0.305,"mebendazole, parbendazole, vincristine, indibulin, taltobulin, combretastatin.A.4, oxibendazole, dolastatin.10, plinabulin, epothilone.b, KX2.391, albendazole, vinorelbine, verubulin, podophyllotoxin",0.826813731587726,0.515700160653214,FALSE
+"H1648","Pearson.est","tyrosine kinase inhibitor",0.45294,1.16,0.282,227,0.489,"regorafenib, sorafenib, cabozantinib, bafetinib, sunitinib, apatinib, mubritinib, tyrphostin.A9",0.549750891680639,0.31069114087638,FALSE
+"H1648","Pearson.est","VEGFR inhibitor",0.53339,1.37,0.143,457,0.305,"motesanib, foretinib, regorafenib, sorafenib, cabozantinib, sunitinib, pazopanib, dovitinib, lenvatinib, TG.100572, PD.173074, OSI.930, golvatinib, cediranib, tivozanib, RAF265, AEE788, BMS.690514, XL.647, ENMD.2076, axitinib, orantinib, linifanib, vatalanib",0.844663962534938,0.515700160653214,FALSE
+"H1648","Pearson.est","vitamin D receptor agonist",-0.26025,-0.658,0.85,829,0.888,"alfacalcidol, doxercalciferol, ercalcitriol, paricalcitol, calcitriol",0.0705810742857073,0.051587034221399,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.47283,1.19,0.247,345,0.673,"tucatinib, poziotinib, lapatinib, AZD8931, dacomitinib, neratinib, BMS.690514, CUDC.101, CP.724714, TAK.285, osimertinib, AST.1306, afatinib, GW.583340, AEE788, ARRY.334543, WZ.3146, BIBU.1361, WZ.4002",0.607303046740334,0.171984935776023,FALSE
+"H1975","Pearson.est","Abl kinase inhibitor",-0.66334,-1.71,0.039,1164,0.179,"bosutinib, nilotinib, GZD824, tozasertib, KW.2449, ZM.306416, metatinib, ponatinib, dasatinib",1.4089353929735,0.747146969020107,TRUE
+"H1975","Pearson.est","acetylcholine receptor agonist",-0.54108,-1.39,0.143,1261,0.353,"tremorine, nicotine",0.844663962534938,0.452225294612177,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",0.41792,1.03,0.434,119,0.804,"diphemanil, hyoscyamine",0.362510270487489,0.0947439512515487,FALSE
+"H1975","Pearson.est","adenosine receptor antagonist",0.85585,2.16,0,54,0.00532,"MRS.1220, CGS.15943, SCH.58261",Inf,2.27408836770495,TRUE
+"H1975","Pearson.est","adrenergic receptor agonist",-0.48719,-1.23,0.241,1103,0.454,"oxymetazoline, ritodrine, terbutaline, A61603, clenbuterol, epinephrine, isoxsuprine, midodrine",0.617982957425132,0.342944147142896,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.36973,0.92,0.521,210,0.88,"practolol, prazosin, propranolol, atipamezole, atenolol......",0.283162276700476,0.0555173278498314,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.57653,1.45,0.107,46,0.389,"GDC.0068, uprosertib, GSK2110183",0.97061622231479,0.410050398674292,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.47706,-1.24,0.201,1252,0.499,"AZD3463, lorlatinib, brigatinib, AP26113",0.696803942579511,0.30189945437661,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",-0.36028,-0.921,0.532,1182,0.722,"cyproterone.acetate, enzalutamide",0.274088367704952,0.141462802430361,FALSE
+"H1975","Pearson.est","antioxidant",-0.68835,-1.77,0.018,1004,0.147,"mesna, chlorogenic.acid, trolox, taurine, benfotiamine",1.74472749489669,0.832682665251824,TRUE
+"H1975","Pearson.est","AP inhibitor",-0.31858,-0.815,0.67,1411,0.842,"idronoxil",0.173925197299174,0.0746879085003505,FALSE
+"H1975","Pearson.est","ATPase inhibitor",0.35504,0.863,0.635,126,0.935,"evodiamine, oligomycin.a, NMS.873",0.197226274708024,0.0291883891274822,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",0.32233,0.798,0.694,530,0.921,"PHA.680632, TAK.901, aurora.a.inhibitor.i, danusertib, barasertib.HQPA, CCT137690, barasertib, alisertib, SNS.314, PF.03814735, MLN.8054, ENMD.2076, AT.9283",0.158640529545145,0.0357403698031511,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.19306,0.487,0.973,1170,0.982,"radezolid, valnemulin, tedizolid, josamycin, tilmicosin, azithromycin, azalomycin.b, dirithromycin",0.0118871597316481,0.00788851221305034,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",0.61474,1.54,0.0628,308,0.419,"trovafloxacin, nadifloxacin, sarafloxacin",1.2020403562628,0.377785977033705,FALSE
+"H1975","Pearson.est","BCL inhibitor",0.56585,1.42,0.112,352,0.409,"TW.37, HA14.1, obatoclax, gossypol",0.950781977329818,0.388276691992658,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.63151,-1.58,0.0532,1164,0.237,"bosutinib, nilotinib, GZD824, tozasertib, metatinib, ponatinib, dasatinib",1.27408836770495,0.625251653989896,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.59026,1.48,0.108,173,0.443,"ZK.93423, piperazine, zaleplon, ivermectin, gamma.aminobutyric.acid",0.96657624451305,0.35359627377693,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",0.9087,2.25,0,47,0.00106,"I.BET151, OTX015, JQ1...., I.BET.762, bromosporine",Inf,2.97469413473523,TRUE
+"H1975","Pearson.est","calcium channel blocker",0.63835,1.61,0.0459,292,0.378,"SR.33805, cinnarazine, pranidipine, mibefradil, SKF.96365",1.33818731446274,0.422508200162775,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",0.51465,1.3,0.186,84,0.559,"SB.225002, ZK811752",0.730487055782084,0.252588192113577,FALSE
+"H1975","Pearson.est","CDK inhibitor",-0.25915,-0.684,0.844,1174,0.915,"dinaciclib, AT.7519, AZD5438, abemaciclib, aminopurvalanol.a, alvocidib, PHA.848125",0.073657553374345,0.0385789059335517,FALSE
+"H1975","Pearson.est","CHK inhibitor",-0.76883,-1.99,0.00222,1192,0.0648,"PF.477736, CHIR.124, LY2603618, AZD7762, SCH.900776, LY2606368",2.65364702554936,1.18842499412941,TRUE
+"H1975","Pearson.est","cyclooxygenase inhibitor",0.39979,1,0.417,444,0.775,"piroxicam, pterostilbene, naproxen, curcumin, AM.404, ramifenazone, meloxicam, tepoxalin, tryptanthrin, amfenac",0.379863945026242,0.11069829749369,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.59317,-1.54,0.0583,1275,0.231,"metyrapone, eplerenone, itraconazole",1.23433144524099,0.636388020107856,FALSE
+"H1975","Pearson.est","DNA alkylating agent",-0.29426,-0.762,0.722,1413,0.864,"streptozotocin, carboplatin",0.141462802430361,0.0634862575211067,FALSE
+"H1975","Pearson.est","DNA inhibitor",0.20786,0.522,0.968,441,1,"chlorambucil, primaquine, oxaliplatin, melphalan, valrubicin, metronidazole, teroxirone",0.0141246426916063,0,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.56036,1.39,0.125,164,0.433,"fdcyd, SGI.1027, azacitidine",0.903089986991944,0.363512103646635,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",-0.30598,-0.778,0.709,1028,0.87,"foscarnet, menadione, famciclovir",0.149353764816933,0.0604807473813815,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",0.22198,0.557,0.943,561,1,"floxuridine, anisomycin, artemisinin, enocitabine, mitomycin.c, artesunate, estramustine.phosphate, azodicarbonamide",0.0254883072626717,0,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",0.25793,0.644,0.875,122,1,"lurasidone, sertindole, clebopride",0.0579919469776868,0,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.54265,-1.4,0.141,1216,0.367,"estradiol, estradiol.cypionate, PPT",0.85078088734462,0.435333935747911,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",0.40272,1,0.452,159,0.775,"clomifene, fulvestrant",0.344861565188618,0.11069829749369,FALSE
+"H1975","Pearson.est","FGFR inhibitor",-0.33875,-0.878,0.545,1304,0.766,"lucitanib, AZD4547",0.263603497723358,0.115771230367396,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",-0.43881,-1.12,0.333,1237,0.565,"tozasertib, tyrphostin.AG.1296, KW.2449, midostaurin, ponatinib, gilteritinib",0.47755576649368,0.247951552180562,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",-0.1953,-0.505,0.967,1205,0.976,"triamcinolone, dexamethasone.acetate, flumethasone.pivalate, prednisolone.acetate, fluorometholone, fluocinolone.acetonide",0.0145735259169983,0.0105501823333082,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",-0.21611,-0.555,0.957,1055,1,"tiletamine, LY456236, JNJ.16259685, SIB.1757",0.0190880622231565,0,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.4039,-1.04,0.374,975,0.638,"AZD2858, GSK.3.inhibitor.IX, indirubin, TWS.119, LY2090314, CHIR.98014, tideglusib",0.42712839779952,0.195179321278838,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",-0.50912,-1.32,0.176,1187,0.413,"GSK1838705A, AZD3463, PHA.848125",0.75448733218585,0.384049948343599,FALSE
+"H1975","Pearson.est","HCV inhibitor",0.41202,1.04,0.417,479,0.818,"PSI.7976, daclatasvir, embelin, Ro.9187, mericitabine",0.379863945026242,0.087246696328677,FALSE
+"H1975","Pearson.est","HDAC inhibitor",0.3181,0.808,0.683,472,0.93,"R306465, M.344, RGFP966, ACY.1215, AR.42, romidepsin, tacedinaline, pyroxamide, PCI.24781, scriptaid, NSC.3852",0.165579296318467,0.0315170514460649,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",0.38714,0.994,0.451,307,0.759,"chloropyramine, ranitidine, epinastine, ICI.162846, cimetidine",0.345823458122039,0.11975822410452,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.83844,-2.17,0,1334,0.0257,"lovastatin, mevastatin, pitavastatin, fluvastatin",Inf,1.59006687666871,TRUE
+"H1975","Pearson.est","HSP inhibitor",0.31531,0.761,0.739,496,0.935,"NMS.E973, guanidine, tanespimycin, BIIB021, SNX.5422, VER.49009, XL888",0.131355561605174,0.0291883891274822,FALSE
+"H1975","Pearson.est","JAK inhibitor",-0.27194,-0.695,0.812,983,0.93,"TG.101209, WHI.P154, ruxolitinib, AZ960, PRT062070, tozasertib, CEP.33779",0.0904439707588247,0.0315170514460649,FALSE
+"H1975","Pearson.est","KIT inhibitor",-0.44169,-1.18,0.237,1314,0.499,"telatinib, midostaurin, KI.8751, dasatinib",0.625251653989896,0.30189945437661,FALSE
+"H1975","Pearson.est","MDM inhibitor",0.6742,1.71,0.0284,445,0.411,"nutlin.3, idasanutlin, AMG.232, RITA, CGM097",1.54668165995296,0.386158178123931,FALSE
+"H1975","Pearson.est","MEK inhibitor",-0.60835,-1.54,0.0682,1010,0.231,"MEK1.2.inhibitor, PD.318088, Ro.4987655, selumetinib, trametinib, TAK.733, AZD8330, MEK162, PD.184352, refametinib, cobimetinib, nobiletin, BIX.02188",1.16621562534352,0.636388020107856,FALSE
+"H1975","Pearson.est","MET inhibitor",-0.65001,-1.67,0.035,1263,0.191,"PHA.665752, LY2801653",1.45593195564972,0.718966632752272,TRUE
+"H1975","Pearson.est","microtubule inhibitor",-0.36096,-0.957,0.479,1013,0.755,"secnidazole, cabazitaxel, colchicine, vinblastine, D.64131, cytochalasin.b",0.319664486585437,0.122053048370812,FALSE
+"H1975","Pearson.est","mTOR inhibitor",0.46173,1.16,0.28,392,0.697,"PF.05212384, WYE.125132, PI.103, sirolimus, GSK2126458, voxtalisib, PP242, everolimus, torin.1, deforolimus, GDC.0980, PKI.179, temsirolimus, torin.2",0.552841968657781,0.156767221901991,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",0.32335,0.809,0.69,293,0.955,"EVP4593, curcumin, BAY.11.7085",0.161150909262745,0.0199966284162537,FALSE
+"H1975","Pearson.est","opioid receptor agonist",0.24064,0.594,0.925,1101,1,"salvinorin.a, spiradoline, ADL5859, cebranopadol, BW.180C, trimebutine",0.0338582672609674,0,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",0.66312,1.67,0.027,230,0.318,"skepinone.l, SB.242235, SB.239063",1.56863623584101,0.497572880015567,FALSE
+"H1975","Pearson.est","PARP inhibitor",0.42512,1.07,0.35,474,0.822,"PJ.34, niraparib, AG.14361, AZD2461",0.455931955649724,0.0851281824599496,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.36377,-0.938,0.492,1243,0.724,"SU014813, crenolanib, telatinib, KI.8751, ponatinib, dasatinib",0.30803489723264,0.140261433802853,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",0.27307,0.687,0.84,178,1,"mycophenolate.mofetil, mycophenolic.acid",0.0757207139381184,0,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",-0.36447,-0.954,0.512,1094,0.727,"anagrelide, trequinsin, GSK256066, papaverine, YM.976",0.290730039024169,0.138465589140962,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.55917,1.45,0.107,374,0.389,"PF.05212384, taselisib, alpelisib, PI.103, PI.828, CH5132799, GSK2126458, buparlisib, CUDC.907, voxtalisib, YM.201636, GDC.0980, PI3K.IN.2, PKI.179, BGT226",0.97061622231479,0.410050398674292,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.47714,1.2,0.268,224,0.729,"HMN.214, GW.843682X",0.571865205971211,0.137272471682025,FALSE
+"H1975","Pearson.est","potassium channel blocker",-0.47468,-1.23,0.225,1382,0.454,"meglitinide",0.647817481888638,0.342944147142896,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",0.61216,1.54,0.0691,108,0.419,"pterostilbene, ciprofibrate",1.1605219526258,0.377785977033705,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.74574,-1.98,0.00227,1311,0.0469,"norethindrone, danazol, norethindrone.acetate, dienogest, nomegestrol.acetate",2.64397414280688,1.32882715728492,TRUE
+"H1975","Pearson.est","proteasome inhibitor",0.24903,0.618,0.899,585,1,"ONX.0914, oprozomib, delanzomib, carfilzomib, MG.132",0.0462403082667712,0,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.35324,0.892,0.552,438,0.907,"bruceantin, azomycin..2.nitroimidazole., harringtonine, clofoctol, thiostrepton, homoharringtonine, clindamycin.phosphate",0.258060922270801,0.0423927129399047,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.47182,1.19,0.261,255,0.673,"mubritinib, CP.724714, tyrphostin.A9",0.583359492661719,0.171984935776023,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.32005,0.809,0.67,398,0.955,"SB.590885, GDC.0879, AZ.628, regorafenib",0.173925197299174,0.0199966284162537,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.41217,1.02,0.433,667,0.792,"apatinib, regorafenib, sunitinib, sorafenib, cabozantinib",0.363512103646635,0.101274818410506,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.66961,1.67,0.0383,315,0.318,"adarotene, fenretinide, bexarotene, tamibarotene, AM.580",1.41680122603138,0.497572880015567,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.30884,0.771,0.731,155,0.944,"cytarabine, LY2334737",0.13608262304214,0.025028005701931,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.62501,-1.61,0.0487,1446,0.232,"aripiprazole",1.31247103878537,0.6345120151091,TRUE
+"H1975","Pearson.est","serotonin receptor antagonist",-0.40827,-1.06,0.372,1343,0.634,"RS.16566, SB.216641, aripiprazole",0.429457060118102,0.197910742118267,FALSE
+"H1975","Pearson.est","sodium channel blocker",0.40784,1.04,0.403,240,0.818,"benzethonium, ajmaline, quinidine, triamterene",0.39469495385889,0.087246696328677,FALSE
+"H1975","Pearson.est","src inhibitor",-0.67804,-1.78,0.0243,1164,0.173,"bosutinib, PP.1, PP.2, ZM.306416, dasatinib",1.61439372640169,0.761953896871205,TRUE
+"H1975","Pearson.est","sterol demethylase inhibitor",0.42946,1.09,0.352,167,0.814,"posaconazole, chlormidazole",0.453457336521869,0.0893755951107988,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.59789,1.47,0.0983,243,0.421,"D.4476, SB.525334, adaprev, LY2109761",1.00744648216786,0.375717904164332,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.34702,0.86,0.618,493,0.913,"raltitrexed, trifluridine, ftorafur, doxifluridine",0.209011524911184,0.039529222465701,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",0.22743,0.582,0.946,78,1,"doxorubicin, etoposide.phosphate, epirubicin",0.0241088635982073,0,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",0.21344,0.534,0.972,434,1,"taltobulin, indibulin, parbendazole, vincristine, vinorelbine, combretastatin.A.4, nocodazole, oxibendazole",0.0123337350737254,0,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",-0.19936,-0.53,0.977,1296,0.995,"AMG.208, aminopurvalanol.a, dasatinib",0.0101054362812269,0.00217691925427455,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",0.20309,0.507,0.971,435,0.996,"BMS.690514, linifanib, golvatinib, lenvatinib, AEE788, orantinib, motesanib, foretinib, pazopanib, regorafenib, dovitinib, MGCD.265, OSI.930",0.0127807700919951,0.00174066157630127,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.60223,1.52,0.0833,442,0.409,"calcitriol, maxacalcitol, paricalcitol, doxercalciferol, tacalcitol",1.07935499859321,0.388276691992658,FALSE
+"HCC78","Pearson.est","EGFR inhibitor",-0.38824,-0.921,0.597,767,0.741,"FERb.033, CP.724714, tucatinib, BMS.690514, erlotinib, AZD8931, icotinib, PD.153035, brigatinib, neratinib, BIBX.1382, gefitinib, afatinib, OSI.420, TAK.285, BMS.599626, AST.1306, XL.647, salvianolic.acid.B, WZ.4002, rociletinib, WZ8040, vandetanib, BIBU.1361, ARRY.334543, GW.583340, osimertinib, CUDC.101",0.224025668870631,0.130181792020672,FALSE
+"HCC78","Pearson.est","Abl kinase inhibitor",-0.6095,-1.43,0.0933,1069,0.36,"bosutinib, flumatinib, ponatinib, imatinib, metatinib, bafetinib, tozasertib, KW.2449",1.0301183562535,0.443697499232713,FALSE
+"HCC78","Pearson.est","acetylcholine receptor agonist",-0.52997,-1.23,0.225,1122,0.478,"nefiracetam, pilocarpine",0.647817481888638,0.320572103387881,FALSE
+"HCC78","Pearson.est","acetylcholine receptor antagonist",0.56796,1.64,0.0452,629,0.25,"hyoscyamine, diphemanil, darifenacin, dicycloverine, methscopolamine, iododexetimide",1.34486156518862,0.602059991327962,FALSE
+"HCC78","Pearson.est","adenosine receptor antagonist",-0.46353,-1.1,0.353,1372,0.533,"CGS.15943",0.452225294612177,0.273272790973428,FALSE
+"HCC78","Pearson.est","adrenergic receptor agonist",-0.20316,-0.472,0.984,787,0.987,"ritodrine, A61603, buphenine, isoetharine, metaraminol, isoxsuprine, clenbuterol, midodrine",0.00700490156865849,0.00568284733036327,FALSE
+"HCC78","Pearson.est","adrenergic receptor antagonist",0.23956,0.676,0.837,114,0.862,"imiloxan, RS.17053, practolol",0.07727454200674,0.0644927341752872,FALSE
+"HCC78","Pearson.est","AKT inhibitor",-0.63934,-1.5,0.0537,1195,0.329,"GDC.0068, ONC201, MK.2206, A.674563, uprosertib, triciribine",1.27002571430044,0.482804102050026,FALSE
+"HCC78","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.47526,-1.14,0.301,1086,0.513,"crizotinib, NVP.TAE684, alectinib, AZD3463, CEP.37440, DMH1",0.521433504406157,0.289882634888184,FALSE
+"HCC78","Pearson.est","androgen receptor antagonist",0.42441,1.28,0.182,836,0.396,"nilutamide, bicalutamide, flutamide, RU.58841, cyproterone.acetate, enzalutamide",0.739928612014925,0.402304814074488,FALSE
+"HCC78","Pearson.est","antioxidant",-0.46751,-1.12,0.339,969,0.523,"trolox, chlorogenic.acid, taurine",0.469800301796918,0.281498311132726,FALSE
+"HCC78","Pearson.est","AP inhibitor",0.48978,1.39,0.119,111,0.313,"birinapant, GDC.0152",0.924453038607469,0.504455662453552,FALSE
+"HCC78","Pearson.est","ATPase inhibitor",0.35499,0.985,0.428,8,0.586,"k.strophanthidin, ouabain",0.368556230986828,0.232102383981909,FALSE
+"HCC78","Pearson.est","Aurora kinase inhibitor",-0.69449,-1.64,0.0279,1180,0.2,"alisertib, PF.03814735, barasertib.HQPA, SNS.314, barasertib, MK.8745, ENMD.2076, AMG900, tozasertib, AT.9283, KW.2449, CCT137690, hesperadin, ZM.447439",1.5543957967264,0.698970004336019,TRUE
+"HCC78","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.56364,-1.34,0.132,1025,0.427,"radezolid, dirithromycin, azalomycin.b, azithromycin, valnemulin",0.87942606879415,0.369572124974976,FALSE
+"HCC78","Pearson.est","bacterial DNA gyrase inhibitor",0.5299,1.46,0.0894,306,0.276,"lomefloxacin, sarafloxacin, finafloxacin, trovafloxacin, sparfloxacin, norfloxacin",1.04866248120408,0.559090917934782,FALSE
+"HCC78","Pearson.est","BCL inhibitor",-0.4918,-1.16,0.31,837,0.49,"ABT.737, oridonin, venetoclax, navitoclax, gossypol, TW.37",0.508638306165727,0.309803919971486,FALSE
+"HCC78","Pearson.est","Bcr.Abl kinase inhibitor",-0.62167,-1.46,0.0794,1069,0.324,"bosutinib, flumatinib, ponatinib, imatinib, metatinib, bafetinib, tozasertib",1.1001794975729,0.489454989793388,FALSE
+"HCC78","Pearson.est","benzodiazepine receptor agonist",0.29541,0.858,0.606,41,0.762,"eprinomectin, gamma.aminobutyric.acid",0.217527375833714,0.1180450286604,FALSE
+"HCC78","Pearson.est","bromodomain inhibitor",-0.91886,-2.18,0,1325,0,"bromosporine, I.BET.762, PFI.1, OTX015, I.BET151, JQ1....",Inf,Inf,TRUE
+"HCC78","Pearson.est","calcium channel blocker",-0.57594,-1.35,0.108,940,0.428,"cinnarazine, mibefradil, tetrandrine, SR.33805, carboxyamidotriazole, penfluridol",0.96657624451305,0.368556230986828,FALSE
+"HCC78","Pearson.est","CC chemokine receptor antagonist",-0.5887,-1.39,0.0999,981,0.366,"MK.0812, RS.504393, SB.225002, navarixin, PF.04136309, ZK811752",1.00043451177402,0.436518914605589,FALSE
+"HCC78","Pearson.est","CDK inhibitor",-0.72925,-1.72,0.0156,1258,0.148,"JNJ.7706621, AT.7519, BMS.265246, aminopurvalanol.a, indisulam, ribociclib, PHA.848125, TG.02, kenpaullone, AZD5438, dinaciclib, P276.00, alvocidib, palbociclib, abemaciclib",1.80687540164554,0.829738284605043,TRUE
+"HCC78","Pearson.est","CHK inhibitor",-0.55673,-1.32,0.151,972,0.424,"SCH.900776, LY2606368, SB.218078, LY2603618",0.821023052706831,0.372634143407267,FALSE
+"HCC78","Pearson.est","cyclooxygenase inhibitor",-0.34138,-0.793,0.753,1130,0.884,"ramifenazone, aspirin, phenazone, ketoprofen, tryptanthrin, FR.122047",0.123205023799299,0.0535477349869269,FALSE
+"HCC78","Pearson.est","cytochrome P450 inhibitor",0.39976,1.18,0.243,163,0.445,"eplerenone, morin, metyrapone",0.614393726401688,0.351639989019068,FALSE
+"HCC78","Pearson.est","DNA alkylating agent",-0.49835,-1.18,0.271,960,0.51,"satraplatin, ifosfamide, cisplatin, streptozotocin, melphalan, TH.302, cyclophosphamide, estramustine, mitomycin.c",0.567030709125594,0.292429823902064,FALSE
+"HCC78","Pearson.est","DNA inhibitor",-0.22196,-0.527,0.969,980,1,"pibenzimol, mechlorethamine, melphalan, primaquine, teroxirone, oxaliplatin",0.0136762229492347,0,FALSE
+"HCC78","Pearson.est","DNA methyltransferase inhibitor",-0.67841,-1.6,0.0263,1257,0.209,"azacitidine, decitabine, fdcyd",1.58004425151024,0.679853713888946,TRUE
+"HCC78","Pearson.est","DNA polymerase inhibitor",-0.5469,-1.29,0.172,1223,0.429,"foscarnet, adefovir.dipivoxil, trifluridine, idoxuridine",0.764471553092451,0.367542707815276,FALSE
+"HCC78","Pearson.est","DNA synthesis inhibitor",-0.48294,-1.13,0.31,1175,0.519,"artesunate, enocitabine, anisomycin, cyclocytidine, mitomycin.c",0.508638306165727,0.284832642151542,FALSE
+"HCC78","Pearson.est","dopamine receptor antagonist",-0.20369,-0.48,0.985,805,1,"UH.232...., raclopride, lurasidone, mesoridazine, piperacetazine, paliperidone, acetophenazine, sertindole",0.00656376950238827,0,FALSE
+"HCC78","Pearson.est","estrogen receptor agonist",0.27985,0.807,0.686,309,0.807,"ethinyl.estradiol, levonorgestrel, estradiol.cypionate, equol, erteberel",0.163675884293248,0.0931264652779296,FALSE
+"HCC78","Pearson.est","estrogen receptor antagonist",0.28205,0.78,0.689,32,0.806,"tamoxifen",0.161780778092374,0.0936649581949093,FALSE
+"HCC78","Pearson.est","FGFR inhibitor",-0.51804,-1.22,0.222,1376,0.482,"lucitanib, regorafenib",0.653647025549361,0.31695296176115,FALSE
+"HCC78","Pearson.est","FLT3 inhibitor",-0.62176,-1.5,0.0595,1112,0.329,"gilteritinib, ponatinib, TG.101348, quizartinib, TG.02, ENMD.2076, tozasertib, KW.2449, sorafenib, pacritinib",1.22548303427145,0.482804102050026,FALSE
+"HCC78","Pearson.est","glucocorticoid receptor agonist",0.62046,1.77,0.0303,129,0.305,"hydrocortisone, halcinonide, triamcinolone.acetonide, piretanide, dexamethasone.acetate, fluocinolone.acetonide, desonide",1.5185573714977,0.515700160653214,FALSE
+"HCC78","Pearson.est","glutamate receptor antagonist",0.64484,1.76,0.0341,224,0.212,"latrepirdine, JNJ.16259685, kynurenic.acid, CPP, CGP.37849, felbamate, IEM1754",1.4672456210075,0.673664139071249,TRUE
+"HCC78","Pearson.est","glycogen synthase kinase inhibitor",-0.23241,-0.546,0.958,878,1,"GSK.3.inhibitor.IX, LY2090314, indirubin, AZD2858, kenpaullone",0.0186344909214556,0,FALSE
+"HCC78","Pearson.est","growth factor receptor inhibitor",-0.60838,-1.4,0.0955,1330,0.393,"PHA.848125, AZD3463, GSK1838705A",1.01999662841625,0.405607449624573,FALSE
+"HCC78","Pearson.est","HCV inhibitor",-0.50399,-1.17,0.27,847,0.515,"mericitabine, embelin, Ro.9187, narlaprevir",0.568636235841013,0.288192770958809,FALSE
+"HCC78","Pearson.est","HDAC inhibitor",-0.72749,-1.74,0.0124,1290,0.163,"SB.939, panobinostat, chidamide, PCI.24781, scriptaid, AR.42, givinostat, trichostatin.a, belinostat, dacinostat, M.344, vorinostat, R306465, RG2833, resminostat",1.90657831483776,0.787812395596042,TRUE
+"HCC78","Pearson.est","histamine receptor antagonist",-0.25317,-0.594,0.941,1018,1,"levocetirizine, nizatidine, BF2.649, terfenadine, cyproheptadine, tiotidine",0.0264103765727431,0,FALSE
+"HCC78","Pearson.est","HMGCR inhibitor",0.82927,2.38,0,64,0.0128,"pitavastatin, fluvastatin, mevastatin, atorvastatin",Inf,1.89279003035213,TRUE
+"HCC78","Pearson.est","HSP inhibitor",-0.2995,-0.702,0.836,806,0.934,"SNX.5422, PU.H71, alvespimycin, XL888, ganetespib, NVP.AUY922, tanespimycin",0.0777937225609836,0.0296531237699066,FALSE
+"HCC78","Pearson.est","JAK inhibitor",-0.56327,-1.33,0.139,1289,0.426,"PRT062070, TG.101209, TG.02, tozasertib, AT.9283, pacritinib",0.856985199745905,0.370590400897281,FALSE
+"HCC78","Pearson.est","KIT inhibitor",-0.49064,-1.16,0.295,1039,0.49,"tandutinib, masitinib, telatinib, imatinib, pazopanib, KI.8751, regorafenib, sorafenib",0.530177984021837,0.309803919971486,FALSE
+"HCC78","Pearson.est","MDM inhibitor",0.44437,1.26,0.185,200,0.38,"AMG.232, idasanutlin, CGM097, nutlin.3",0.732828271596986,0.42021640338319,FALSE
+"HCC78","Pearson.est","MEK inhibitor",-0.31735,-0.748,0.804,754,0.912,"selumetinib, PD.184352, AZD8330, MEK162, refametinib, cobimetinib, trametinib, BIX.02188, arctigenin, nobiletin",0.0947439512515487,0.0400051616715838,FALSE
+"HCC78","Pearson.est","MET inhibitor",-0.40467,-0.953,0.536,951,0.715,"INC.280, AMG458, LY2801653",0.27083521030723,0.145693958198919,FALSE
+"HCC78","Pearson.est","microtubule inhibitor",-0.45716,-1.07,0.389,778,0.562,"cytochalasin.b, colchicine, podophyllotoxin, vinflunine, cabazitaxel, D.64131",0.410050398674292,0.250263684430939,FALSE
+"HCC78","Pearson.est","mTOR inhibitor",-0.46778,-1.11,0.334,927,0.528,"temsirolimus, palomid.529, everolimus, LY303511, SB.2343, LY3023414, AZD8055, XL388, NVP.BEZ235, WYE.125132, WYE.354, GDC.0980, GSK2126458, AZD2014, torin.2, MLN0128",0.476253533188435,0.277366077466188,FALSE
+"HCC78","Pearson.est","NFkB pathway inhibitor",-0.54161,-1.28,0.159,1202,0.415,"Ro.106.9920, EVP4593, bortezomib, betulinic.acid",0.798602875679548,0.381951903287907,FALSE
+"HCC78","Pearson.est","opioid receptor agonist",0.52165,1.51,0.0579,138,0.318,"BW.180C, cebranopadol, spiradoline, ADL5859",1.23732143627256,0.497572880015567,FALSE
+"HCC78","Pearson.est","p38 MAPK inhibitor",-0.5539,-1.31,0.145,1054,0.426,"SB.242235, SB.239063, talmapimod",0.838631997765025,0.370590400897281,FALSE
+"HCC78","Pearson.est","PARP inhibitor",-0.624,-1.47,0.0508,1226,0.36,"niraparib, E7449, olaparib, talazoparib",1.29413628771608,0.443697499232713,FALSE
+"HCC78","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52414,-1.23,0.202,1039,0.478,"tandutinib, masitinib, trapidil, telatinib, ponatinib, imatinib, CP.673451, pazopanib, KI.8751, crenolanib, regorafenib, sorafenib",0.694648630553376,0.320572103387881,FALSE
+"HCC78","Pearson.est","phosphatase inhibitor",-0.31824,-0.734,0.821,1106,0.913,"mycophenolic.acid, CID.5458317, GSK2830371",0.0856568428805592,0.039529222465701,FALSE
+"HCC78","Pearson.est","phosphodiesterase inhibitor",0.35605,1.01,0.403,936,0.583,"EMD.53998, anagrelide, zardaverine, avanafil, cilostamide, papaverine, GSK256066, trequinsin, enoximone, YM.976",0.39469495385889,0.234331445240986,FALSE
+"HCC78","Pearson.est","PI3K inhibitor",-0.38458,-0.909,0.603,715,0.747,"voxtalisib, PKI.179, GDC.0941, taselisib, TG100.115, YM.201636, ZSTK.474, PF.04691502, buparlisib, LY303511, SB.2343, LY3023414, TG.100713, BGT226, alpelisib, NVP.BEZ235, CUDC.907, CH5132799, GDC.0980, GSK2126458, PIK.75, PI3K.IN.2",0.219682687859849,0.126679398184601,FALSE
+"HCC78","Pearson.est","PLK inhibitor",-0.75212,-1.78,0.0086,1098,0.161,"NMS.1286937, rigosertib, GSK461364, GW.843682X, BI.2536, volasertib",2.06550154875643,0.79317412396815,TRUE
+"HCC78","Pearson.est","potassium channel blocker",-0.39447,-0.93,0.569,1117,0.74,"oleoylethanolamide, ML133",0.244887733604929,0.130768280269024,FALSE
+"HCC78","Pearson.est","PPAR receptor agonist",0.25778,0.737,0.802,365,0.824,"clofibrate, fenofibrate, ciprofibrate, GW.501516",0.0958256317158365,0.0840727883028842,FALSE
+"HCC78","Pearson.est","progesterone receptor agonist",-0.33901,-0.791,0.743,1096,0.871,"nomegestrol.acetate, melengestrol.acetate, dienogest",0.129011186239425,0.0599818449923368,FALSE
+"HCC78","Pearson.est","proteasome inhibitor",-0.34502,-0.824,0.693,1353,0.854,"bortezomib",0.159266765388193,0.068542129310995,FALSE
+"HCC78","Pearson.est","protein synthesis inhibitor",-0.24646,-0.577,0.947,820,1,"bruceantin, tedizolid.phosphate, homoharringtonine, florfenicol, azomycin..2.nitroimidazole., emetine, mercaptopurine, anguidine, thiostrepton",0.0236500209967266,0,FALSE
+"HCC78","Pearson.est","protein tyrosine kinase inhibitor",-0.51701,-1.21,0.243,1343,0.485,"tyrphostin.A9, NVP.TAE226",0.614393726401688,0.314258261397736,FALSE
+"HCC78","Pearson.est","RAF inhibitor",-0.54526,-1.29,0.187,1316,0.429,"TAK.632, RAF265, regorafenib, sorafenib",0.728158393463501,0.367542707815276,FALSE
+"HCC78","Pearson.est","RET tyrosine kinase inhibitor",-0.71544,-1.68,0.0121,1154,0.17,"vandetanib, cabozantinib, regorafenib, sorafenib",1.91721462968355,0.769551078621726,TRUE
+"HCC78","Pearson.est","retinoid receptor agonist",-0.49695,-1.19,0.252,1057,0.508,"bexarotene, CD.437, adarotene, fenretinide",0.598599459218456,0.294136287716081,FALSE
+"HCC78","Pearson.est","ribonucleotide reductase inhibitor",-0.4069,-0.962,0.521,644,0.729,"hydroxyurea, gemcitabine, LY2334737, fludarabine.phosphate, pentostatin, cladribine, fludarabine, clofarabine",0.283162276700476,0.137272471682025,FALSE
+"HCC78","Pearson.est","serotonin receptor agonist",0.36893,1.05,0.435,916,0.56,"NAN.190, SR.57227A, pardoprunox, ipsapirone, zolmitriptan, aripiprazole",0.361510743045363,0.2518119729938,FALSE
+"HCC78","Pearson.est","serotonin receptor antagonist",-0.4249,-0.993,0.477,832,0.687,"lurasidone, aripiprazole, tropisetron, RS.16566, SB.216641, paliperidone, SB.228357, sertindole",0.321481620959886,0.16304326294045,FALSE
+"HCC78","Pearson.est","sodium channel blocker",-0.48848,-1.16,0.289,1090,0.49,"triamterene, quinidine, butamben, lappaconite, ajmaline",0.539102157243452,0.309803919971486,FALSE
+"HCC78","Pearson.est","src inhibitor",-0.34754,-0.825,0.722,894,0.869,"PP.2, PP.1, masitinib, bosutinib, KX2.391",0.141462802430361,0.0609802235513335,FALSE
+"HCC78","Pearson.est","sterol demethylase inhibitor",0.51504,1.48,0.0829,428,0.299,"lanoconazole, posaconazole, sulconazole, terconazole, ketoconazole",1.08144546944973,0.52432881167557,FALSE
+"HCC78","Pearson.est","TGF beta receptor inhibitor",0.37309,1.07,0.343,910,0.571,"SB.525334, repsox, LY2109761, adaprev, SB.431542, D.4476",0.464705879957229,0.243363891754152,FALSE
+"HCC78","Pearson.est","thymidylate synthase inhibitor",-0.69991,-1.63,0.00846,1168,0.186,"carmofur, doxifluridine, trifluridine, raltitrexed",2.07262963696098,0.730487055782084,TRUE
+"HCC78","Pearson.est","topoisomerase inhibitor",-0.6301,-1.46,0.0634,1066,0.324,"fleroxacin, amonafide, idarubicin, daunorubicin, beta.lapachone, SN.38, etoposide, licochalcone.a, topotecan, camptothecin, TAS.103, irinotecan, rubitecan, genz.644282, exatecan.mesylate",1.19791074211827,0.489454989793388,FALSE
+"HCC78","Pearson.est","tubulin polymerization inhibitor",-0.39883,-0.953,0.537,680,0.715,"dolastatin.10, verubulin, plinabulin, oxibendazole, vinorelbine, ABT.751, BNC105, epothilone.d, parbendazole, nocodazole, podophyllotoxin, epothilone.b, combretastatin.A.4, flubendazole, KX2.391, taltobulin, paclitaxel, docetaxel, albendazole, fosbretabulin",0.270025714300444,0.145693958198919,FALSE
+"HCC78","Pearson.est","tyrosine kinase inhibitor",-0.58889,-1.39,0.102,1154,0.366,"vandetanib, UNC2250, cabozantinib, aminopurvalanol.a, bafetinib, tyrphostin.A9, hypericin, tivantinib, regorafenib, sorafenib, NVP.TAE226",0.991399828238082,0.436518914605589,FALSE
+"HCC78","Pearson.est","VEGFR inhibitor",-0.46323,-1.07,0.39,1362,0.562,"ENMD.2076, KI.8751, lucitanib, RAF265, golvatinib, regorafenib, sorafenib, foretinib",0.408935392973501,0.250263684430939,FALSE
+"HCC78","Pearson.est","vitamin D receptor agonist",-0.5406,-1.28,0.167,779,0.415,"calcitriol, alfacalcidol, paricalcitol, doxercalciferol, ercalcitriol, maxacalcitol, tacalcitol",0.777283528852417,0.381951903287907,FALSE
+"H2126","Pearson.est","EGFR inhibitor",0.2442,0.593,0.902,149,0.96,"salvianolic.acid.B, CUDC.101, dovitinib, WZ.4002",0.0447934624580583,0.0177287669604316,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",0.50265,1.24,0.225,463,0.449,"bafetinib, ponatinib, tozasertib, imatinib, metatinib, nilotinib, KW.2449, flumatinib, GZD824",0.647817481888638,0.347753658996677,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",-0.38343,-1.02,0.376,1171,0.613,"xanomeline, tremorine, nicotine",0.424812155072339,0.212539525481585,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",-0.35922,-0.967,0.455,518,0.601,"methscopolamine, diphemanil, iododexetimide, darifenacin, dicycloverine, hyoscyamine",0.341988603342888,0.22112552799726,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",0.69637,1.67,0.022,298,0.341,"CGS.15943, MRS.1220",1.65757731917779,0.467245621007502,FALSE
+"H2126","Pearson.est","adrenergic receptor agonist",0.26443,0.645,0.889,195,0.932,"buphenine, clenbuterol, metaraminol",0.0510982390297863,0.0305840876460186,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",0.21945,0.534,0.956,462,0.962,"practolol, atipamezole, atenolol......, prazosin, pindolol, carvedilol, vincamine",0.0195421077238999,0.0168249279621871,FALSE
+"H2126","Pearson.est","AKT inhibitor",0.59946,1.49,0.0679,239,0.346,"uprosertib, GDC.0068, A.674563, ONC201, GSK2110183, MK.2206",1.1681302257195,0.460923901207223,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.46904,1.16,0.282,284,0.5,"crizotinib, DMH1, alectinib, CEP.37440, AZD3463, lorlatinib",0.549750891680639,0.301029995663981,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",-0.46117,-1.26,0.201,665,0.519,"nilutamide, flutamide, enzalutamide, bicalutamide, cyproterone.acetate, RU.58841",0.696803942579511,0.284832642151542,FALSE
+"H2126","Pearson.est","antioxidant",-0.4466,-1.23,0.195,644,0.472,"trolox, taurine, benfotiamine, chlorogenic.acid, mesna, rutin",0.709965388637482,0.326058001365912,FALSE
+"H2126","Pearson.est","AP inhibitor",-0.79753,-2.13,0,1194,0.0344,"idronoxil, tanshinone.i, birinapant, GDC.0152, LCL.161",Inf,1.46344155742847,TRUE
+"H2126","Pearson.est","ATPase inhibitor",0.40611,0.993,0.467,120,0.648,"evodiamine, digoxin, blebbistatin....",0.330683119433888,0.188424994129407,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.58465,1.41,0.0962,368,0.389,"barasertib, CCT137690, AT.9283, tozasertib, CCT129202, aurora.a.inhibitor.i, SNS.314, AMG900, barasertib.HQPA, ZM.447439, alisertib, KW.2449, TAK.901",1.01682492796219,0.410050398674292,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.27591,0.681,0.861,107,0.911,"valnemulin",0.0649968485463452,0.0404816230270017,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",-0.42949,-1.18,0.26,1000,0.471,"sarafloxacin, sparfloxacin, norfloxacin, finafloxacin, lomefloxacin, trovafloxacin",0.585026652029182,0.326979092871104,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.52578,1.28,0.209,479,0.471,"ABT.737, venetoclax, HA14.1, oridonin, TW.37, navitoclax, gossypol",0.679853713888946,0.326979092871104,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.57644,1.43,0.103,288,0.381,"bafetinib, ponatinib, tozasertib, imatinib, metatinib, nilotinib",0.987162775294828,0.419075024324381,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",0.30329,0.739,0.758,468,0.875,"ZK.93423, bentazepam, piperazine, temazepam, ivermectin, nefiracetam",0.120330794367946,0.0579919469776868,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",0.65326,1.61,0.0419,506,0.29,"JQ1...., I.BET151, OTX015, I.BET.762, bromosporine, PFI.1",1.3777859770337,0.537602002101044,FALSE
+"H2126","Pearson.est","calcium channel blocker",0.6198,1.51,0.0723,106,0.339,"carboxyamidotriazole, pranidipine, cinnarazine, penfluridol",1.14086170270547,0.469800301796918,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.45458,1.1,0.353,373,0.52,"ZK811752, PF.04136309, SB.225002, RS.504393",0.452225294612177,0.283996656365201,FALSE
+"H2126","Pearson.est","CDK inhibitor",0.59471,1.46,0.0855,265,0.349,"abemaciclib, indisulam, palbociclib, ribociclib, JNJ.7706621, dinaciclib, arcyriaflavin.a, TG.02, PHA.848125, AZD5438",1.06803388527183,0.45717457304082,FALSE
+"H2126","Pearson.est","CHK inhibitor",-0.64019,-1.72,0.0274,1162,0.257,"CHIR.124, PF.477736, LY2606368, SCH.900776, AZD7762",1.56224943717961,0.590066876668705,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.2577,-0.705,0.778,1239,0.848,"acetylsalicylsalicylic.acid, tryptanthrin, FK.3311, metoxibutropate, amfenac, sulfasalazine, AM.404",0.109020403010311,0.0716041477432862,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",-0.56726,-1.55,0.0807,1234,0.396,"clotrimazole, PF.4981517, eplerenone",1.09312646527793,0.402304814074488,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.43049,1.05,0.407,366,0.587,"estramustine, mitomycin.c, TH.302, melphalan, ifosfamide, cisplatin",0.39040559077478,0.231361898752386,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.33894,0.835,0.664,417,0.787,"melphalan, chlorambucil, oxaliplatin, pibenzimol, metronidazole, nithiamide, mechlorethamine",0.177831920631982,0.104025267640935,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",0.53275,1.31,0.138,152,0.46,"fdcyd, SGI.1027",0.860120913598763,0.337242168318426,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",0.31019,0.776,0.722,297,0.841,"trifluridine, idoxuridine",0.141462802430361,0.0752040042020878,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",0.37633,0.926,0.557,366,0.693,"artesunate, mitomycin.c, enocitabine, cyclocytidine, anisomycin, cisplatin",0.254144804826271,0.159266765388193,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.30815,-0.836,0.654,1319,0.787,"ziprasidone, thioproperazine, raclopride, remoxipride",0.184422251675733,0.104025267640935,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",-0.44758,-1.21,0.222,1107,0.464,"PPT, estradiol.cypionate, erteberel, ethinyl.estradiol, levonorgestrel",0.653647025549361,0.333482019445119,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",-0.45103,-1.25,0.219,1339,0.485,"tamoxifen, raloxifene",0.659555885159882,0.314258261397736,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.5063,1.24,0.223,188,0.449,"regorafenib, erdafitinib, dovitinib, PD.173074",0.651695136951839,0.347753658996677,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.66465,1.62,0.0286,220,0.313,"sorafenib, quizartinib, pacritinib, TG.101348, ponatinib, tozasertib, dovitinib, TG.02, sunitinib",1.54363396687096,0.504455662453552,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",-0.47278,-1.26,0.215,1078,0.519,"triamcinolone, fludroxycortide, fluocinolone.acetonide, halcinonide, difluprednate, piretanide, ciclesonide, triamcinolone.acetonide, fluorometholone, prednisolone.acetate, dexamethasone.acetate, hydrocortisone",0.667561540084395,0.284832642151542,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.49062,-1.34,0.129,1139,0.575,"LY456236, MTPG, kynurenic.acid, IEM1754, CGP.37849, latrepirdine, JNJ.16259685",0.889410289700751,0.24033215531037,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.29912,-0.81,0.672,1160,0.793,"CHIR.98014, CHIR.99021, tideglusib",0.172630726946175,0.100726812682396,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.46259,1.13,0.31,648,0.501,"PHA.848125, AZD3463, GW.441756, GSK1838705A, danusertib, lestaurtinib",0.508638306165727,0.300162274132754,FALSE
+"H2126","Pearson.est","HCV inhibitor",-0.36224,-0.967,0.461,1332,0.601,"narlaprevir",0.336299074610352,0.22112552799726,FALSE
+"H2126","Pearson.est","HDAC inhibitor",0.56432,1.38,0.126,207,0.4,"belinostat, vorinostat, RGFP966, resminostat, R306465, M.344, chidamide, scriptaid, givinostat, RG2833, panobinostat",0.899629454882437,0.397940008672038,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",-0.29654,-0.787,0.755,1231,0.762,"ranitidine, ebastine, astemizole, zolantidine",0.122053048370812,0.1180450286604,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",-0.74594,-2,0.0162,1133,0.0721,"atorvastatin, lovastatin, mevastatin, fluvastatin, pitavastatin",1.79048498545737,1.14206473528057,TRUE
+"H2126","Pearson.est","HSP inhibitor",0.34151,0.841,0.651,447,0.812,"NMS.E973, SNX.5422, NVP.AUY922, tanespimycin",0.186419011431808,0.0904439707588247,FALSE
+"H2126","Pearson.est","JAK inhibitor",0.53474,1.33,0.172,172,0.447,"pacritinib, TG.101348, AT.9283, tozasertib, AZ960, TG.02",0.764471553092451,0.349692476868064,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.66938,1.64,0.0241,121,0.331,"sorafenib, pazopanib, regorafenib, motesanib, masitinib, imatinib, KI.8751",1.61798295742513,0.480172006224281,FALSE
+"H2126","Pearson.est","MDM inhibitor",0.47402,1.15,0.307,271,0.486,"serdemetan, nutlin.3",0.512861624522813,0.313363730737707,FALSE
+"H2126","Pearson.est","MEK inhibitor",-0.43064,-1.16,0.266,1050,0.467,"AZD8330, AS.703026, cobimetinib, MEK162, PD.198306, MEK1.2.inhibitor, PD.318088, U.0126, PD.184352, TAK.733, Ro.4987655",0.575118363368933,0.330683119433888,FALSE
+"H2126","Pearson.est","MET inhibitor",0.48978,1.2,0.253,54,0.482,"AMG458",0.596879478824182,0.31695296176115,FALSE
+"H2126","Pearson.est","microtubule inhibitor",0.34255,0.836,0.67,575,0.802,"vinflunine, D.64131, vinblastine, triclabendazole, cabazitaxel, podophyllotoxin",0.173925197299174,0.0958256317158365,FALSE
+"H2126","Pearson.est","mTOR inhibitor",0.52639,1.26,0.201,359,0.467,"WYE.125132, AZD2014, torin.2, everolimus, MLN0128, temsirolimus, PF.05212384, PI.103, NVP.BEZ235, PP242, WYE.354, GSK2126458, SB.2343, LY3023414",0.696803942579511,0.330683119433888,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",0.4181,1.03,0.442,422,0.605,"EVP4593, bortezomib, betulinic.acid, Ro.106.9920, curcumin, BAY.11.7082, bindarit",0.354577730650908,0.218244625347531,FALSE
+"H2126","Pearson.est","opioid receptor agonist",-0.76517,-2.14,0.00625,1393,0.063,"cebranopadol, ADL5859, BW.180C",2.20411998265592,1.20065945054642,TRUE
+"H2126","Pearson.est","p38 MAPK inhibitor",0.46106,1.1,0.349,307,0.52,"skepinone.l, SB.239063",0.45717457304082,0.283996656365201,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.60099,1.48,0.0735,338,0.338,"niraparib, talazoparib, PJ.34, olaparib, AG.14361",1.1337126609158,0.471083299722345,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.65411,1.6,0.0514,121,0.269,"sorafenib, pazopanib, regorafenib, motesanib, masitinib, axitinib, ponatinib, imatinib, dovitinib, KI.8751",1.28903688100472,0.570247719997592,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.31797,0.795,0.725,206,0.829,"GSK2830371, alexidine",0.139661993429006,0.0814454694497265,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",-0.22641,-0.613,0.91,1269,0.915,"YM.976, papaverine",0.0409586076789064,0.0385789059335517,FALSE
+"H2126","Pearson.est","PI3K inhibitor",0.47058,1.15,0.31,414,0.486,"buparlisib, CH5132799, YM.201636, PF.05212384, PI.103, NVP.BEZ235, PIK.75, CUDC.907, GSK2126458, SB.2343, LY3023414, TG100.115, PI3K.IN.2, BGT226",0.508638306165727,0.313363730737707,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.74462,1.83,0.00577,375,0.19,"GW.843682X, volasertib, rigosertib, GSK461364, NMS.1286937, BI.2536, HMN.214",2.23882418684427,0.721246399047171,TRUE
+"H2126","Pearson.est","potassium channel blocker",-0.57127,-1.53,0.0939,1435,0.355,"meglitinide",1.02733440773389,0.449771646944906,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",-0.36849,-0.969,0.489,531,0.663,"S26948, GW.501516, pterostilbene, ciprofibrate, oleoylethanolamide, fenofibrate, clofibrate",0.31069114087638,0.178486471595227,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",-0.40242,-1.13,0.299,1176,0.476,"danazol, dienogest, norethindrone.acetate, levonorgestrel",0.52432881167557,0.322393047279507,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.49276,1.2,0.246,632,0.482,"carfilzomib, bortezomib, MG.132, oprozomib, ixazomib, delanzomib",0.609064892896621,0.31695296176115,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.50738,1.25,0.209,341,0.466,"azomycin..2.nitroimidazole., florfenicol, mercaptopurine, thiostrepton, anguidine, homoharringtonine, tedizolid.phosphate, harringtonine",0.679853713888946,0.33161408331,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.28694,-0.798,0.685,1203,0.778,"rheochrysidin, PP.121, AV.412",0.164309428507574,0.109020403010311,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.48647,1.16,0.291,388,0.5,"sorafenib, regorafenib, RAF265, TAK.632, PLX.4720, SB.590885",0.536107011014093,0.301029995663981,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.73486,1.8,0.00587,220,0.163,"sorafenib, regorafenib, cabozantinib, sunitinib",2.23136189875239,0.787812395596042,TRUE
+"H2126","Pearson.est","retinoid receptor agonist",0.76113,1.83,0.00592,235,0.19,"fenretinide, adarotene, adapalene, bexarotene, AM.580, tamibarotene, CD.437",2.22767829327708,0.721246399047171,TRUE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.40058,0.989,0.443,661,0.639,"cytarabine, LY2334737, pentostatin, fludarabine, fludarabine.phosphate",0.35359627377693,0.1944991418416,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",0.40011,0.978,0.461,2,0.64,"aripiprazole",0.336299074610352,0.193820026016113,FALSE
+"H2126","Pearson.est","serotonin receptor antagonist",0.61874,1.52,0.0647,90,0.391,"aripiprazole, sertindole, paliperidone, lurasidone",1.1890957193313,0.407823242604133,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.5133,1.27,0.206,275,0.469,"ajmaline, brivaracetam, butamben, quinidine, cibenzoline, triamterene",0.686132779630847,0.328827157284917,FALSE
+"H2126","Pearson.est","src inhibitor",-0.48772,-1.31,0.19,1180,0.554,"TG.100572, bosutinib, PP.1, dasatinib, saracatinib, ZM.306416",0.721246399047171,0.25649023527157,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.28862,0.696,0.838,339,0.911,"chlormidazole, posaconazole",0.0767559813697235,0.0404816230270017,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",0.23959,0.59,0.93,593,0.945,"adaprev, D.4476, SB.431542",0.0315170514460649,0.0245681914907371,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.61883,1.51,0.0598,136,0.339,"raltitrexed, trifluridine",1.22329881601159,0.469800301796918,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.53293,1.29,0.2,523,0.474,"topotecan, irinotecan, rubitecan, etoposide.phosphate, idarubicin, exatecan.mesylate, amonafide, epirubicin, genz.644282, camptothecin, daunorubicin, TAS.103, dexrazoxane, SN.38, doxorubicin, teniposide, nemorubicin",0.698970004336019,0.324221658325915,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.48384,1.16,0.28,627,0.5,"albendazole, taltobulin, parbendazole, BNC105, docetaxel, vinorelbine, vindesine, flubendazole, vinblastine, indibulin, combretastatin.A.4, fosbretabulin, verubulin, oxibendazole, KX2.391, paclitaxel, plinabulin, podophyllotoxin, epothilone.d, epothilone.b, nocodazole, dolastatin.10, ABT.751",0.552841968657781,0.301029995663981,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",0.40167,0.974,0.498,425,0.632,"bafetinib, sorafenib, regorafenib, cabozantinib, sunitinib, mubritinib, tivantinib, NVP.TAE226, apatinib, hypericin, tyrphostin.A9",0.302770657240282,0.199282921717615,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",0.57482,1.39,0.12,224,0.406,"sorafenib, foretinib, pazopanib, regorafenib, tivozanib, motesanib, axitinib, golvatinib, dovitinib, KI.8751, cabozantinib, PD.173074, sunitinib, RAF265",0.920818753952375,0.391473966422806,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",0.54679,1.35,0.134,313,0.431,"calcitriol, tacalcitol, maxacalcitol",0.872895201635192,0.365522729839268,FALSE
+"HCC827","Pearson.est","EGFR inhibitor",-0.59737,-1.5,0.0816,1170,0.61,"BIBU.1361, OSI.420, canertinib, CUDC.101, salvianolic.acid.B, afatinib, dacomitinib, PD.153035, AZD8931, erlotinib, BIBX.1382, brigatinib, tyrphostin.AG.1478, PD.168393, tyrphostin.AG.494, gefitinib, WZ8040, pelitinib, XL.647, GW.583340, neratinib, osimertinib, BMS.599626, vandetanib, icotinib",1.08830984124614,0.214670164989233,FALSE
+"HCC827","Pearson.est","Abl kinase inhibitor",-0.49562,-1.28,0.204,1138,0.543,"tozasertib, nilotinib, flumatinib, KW.2449, bosutinib, dasatinib",0.690369832574101,0.265200170411153,FALSE
+"HCC827","Pearson.est","acetylcholine receptor agonist",-0.61329,-1.57,0.0692,1358,0.534,"pilocarpine, nicotine",1.15989390554324,0.272458742971444,FALSE
+"HCC827","Pearson.est","acetylcholine receptor antagonist",0.52196,1.35,0.146,216,0.542,"diphemanil, darifenacin, hyoscyamine",0.835647144215563,0.266000713461613,FALSE
+"HCC827","Pearson.est","adenosine receptor antagonist",0.64976,1.68,0.0436,131,0.32,"MRS.1220, SCH.58261",1.36051351073141,0.494850021680094,FALSE
+"HCC827","Pearson.est","adrenergic receptor agonist",-0.5427,-1.38,0.136,1351,0.524,"epinephrine, terbutaline, isoxsuprine, midodrine, A61603",0.866461091629782,0.280668713016273,FALSE
+"HCC827","Pearson.est","adrenergic receptor antagonist",0.3345,0.856,0.598,262,0.887,"prazosin, practolol, atenolol...., propranolol, RS.17053",0.223298816011589,0.0520763801682736,FALSE
+"HCC827","Pearson.est","AKT inhibitor",0.29387,0.774,0.71,238,0.891,"GDC.0068, GSK2110183, ONC201, uprosertib",0.148741651280925,0.0501222959631252,FALSE
+"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.43379,-1.14,0.289,981,0.589,"alectinib, CEP.37440, GW.788388, lorlatinib, DMH1, AZD3463, brigatinib, AP26113",0.539102157243452,0.229884705212898,FALSE
+"HCC827","Pearson.est","androgen receptor antagonist",-0.50807,-1.29,0.195,927,0.607,"bicalutamide, RU.58841, flutamide, nilutamide, enzalutamide",0.709965388637482,0.216811308924742,FALSE
+"HCC827","Pearson.est","antioxidant",-0.4981,-1.28,0.215,1094,0.543,"taurine, trolox, mesna",0.667561540084395,0.265200170411153,FALSE
+"HCC827","Pearson.est","AP inhibitor",0.3324,0.89,0.57,447,0.884,"birinapant, tanshinone.i, embelin",0.244125144327509,0.0535477349869269,FALSE
+"HCC827","Pearson.est","ATPase inhibitor",0.4297,1.11,0.318,288,0.807,"oligomycin.a, NMS.873, evodiamine, digitoxigenin",0.497572880015567,0.0931264652779296,FALSE
+"HCC827","Pearson.est","Aurora kinase inhibitor",0.29219,0.765,0.736,351,0.879,"PHA.680632, TAK.901, danusertib, CCT137690, CCT129202, barasertib, AT.9283",0.133122185662501,0.0560111249262281,FALSE
+"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.58041,-1.49,0.11,1297,0.474,"tilmicosin, azithromycin, dirithromycin",0.958607314841775,0.324221658325915,FALSE
+"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",0.4323,1.13,0.308,197,0.81,"norfloxacin, nadifloxacin, trovafloxacin",0.511449283499556,0.0915149811213502,FALSE
+"HCC827","Pearson.est","BCL inhibitor",0.35366,0.93,0.52,103,0.947,"obatoclax",0.283996656365201,0.0236500209967266,FALSE
+"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.49342,-1.3,0.186,1138,0.635,"tozasertib, nilotinib, flumatinib, bosutinib, dasatinib",0.730487055782084,0.197226274708024,FALSE
+"HCC827","Pearson.est","benzodiazepine receptor agonist",0.28097,0.738,0.756,284,0.895,"ZK.93423, gamma.aminobutyric.acid, zaleplon",0.121478204498793,0.048176964684088,FALSE
+"HCC827","Pearson.est","bromodomain inhibitor",0.67659,1.77,0.0309,430,0.313,"I.BET151, I.BET.762, JQ1...., OTX015, bromosporine",1.51004152057517,0.504455662453552,FALSE
+"HCC827","Pearson.est","calcium channel blocker",0.51014,1.32,0.169,372,0.553,"SR.33805, carboxyamidotriazole, pranidipine, mibefradil, efonidipine.monoethanolate",0.772113295386326,0.257274868695302,FALSE
+"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.40793,-1.05,0.388,1171,0.657,"MK.0812, PF.04136309, RS.504393, navarixin",0.411168274405793,0.182434630440219,FALSE
+"HCC827","Pearson.est","CDK inhibitor",-0.3083,-0.801,0.696,1236,0.908,"AT.7519, BMS.265246, AZD5438, PHA.848125, aminopurvalanol.a, alvocidib",0.157390760389438,0.0419141514789149,FALSE
+"HCC827","Pearson.est","CHK inhibitor",-0.75295,-1.99,0.00577,1135,0.144,"CHIR.124, LY2603618, SB.218078, AZD7762, SCH.900776, LY2606368",2.23882418684427,0.84163750790475,TRUE
+"HCC827","Pearson.est","cyclooxygenase inhibitor",0.251,0.642,0.869,266,0.922,"AM.404, naproxen, ramifenazone, piroxicam, amfenac",0.0609802235513335,0.0352690789463706,FALSE
+"HCC827","Pearson.est","cytochrome P450 inhibitor",-0.47419,-1.21,0.241,1199,0.593,"eplerenone, itraconazole",0.617982957425132,0.226945306635737,FALSE
+"HCC827","Pearson.est","DNA alkylating agent",-0.35763,-0.923,0.532,1048,0.8,"ifosfamide, dacarbazine, estramustine, temozolomide, carboplatin, streptozotocin",0.274088367704952,0.0969100130080564,FALSE
+"HCC827","Pearson.est","DNA inhibitor",0.25023,0.652,0.857,297,0.959,"teroxirone, valrubicin, chlorambucil, pibenzimol, bendamustine",0.0670191780768018,0.0181813928293364,FALSE
+"HCC827","Pearson.est","DNA methyltransferase inhibitor",0.60006,1.56,0.0626,124,0.361,"fdcyd, SGI.1027, disulfiram",1.20342566678957,0.442492798094342,FALSE
+"HCC827","Pearson.est","DNA polymerase inhibitor",-0.27764,-0.723,0.782,974,0.975,"adefovir.dipivoxil, foscarnet, idoxuridine",0.106793246940152,0.0109953843014632,FALSE
+"HCC827","Pearson.est","DNA synthesis inhibitor",-0.14241,-0.363,0.998,1377,0.999,"capecitabine",0.000869458712628891,0.000434511774017692,FALSE
+"HCC827","Pearson.est","dopamine receptor antagonist",-0.30409,-0.79,0.716,1047,0.898,"sertindole, isofloxythepin, remoxipride, UH.232...., raclopride, piperacetazine, acetophenazine",0.145086977692144,0.0467236633326956,FALSE
+"HCC827","Pearson.est","estrogen receptor agonist",-0.44525,-1.16,0.3,1299,0.584,"estradiol.cypionate, estradiol",0.522878745280338,0.233587152887601,FALSE
+"HCC827","Pearson.est","estrogen receptor antagonist",-0.33773,-0.883,0.553,487,0.817,"raloxifene, fulvestrant, clomifene, toremifene, tamoxifen, danazol",0.257274868695302,0.0877779434675845,FALSE
+"HCC827","Pearson.est","FGFR inhibitor",0.60546,1.58,0.057,253,0.377,"dovitinib, PD.173074, lenvatinib, erdafitinib, AZD4547, nintedanib",1.24412514432751,0.423658649794207,FALSE
+"HCC827","Pearson.est","FLT3 inhibitor",0.34014,0.863,0.598,49,0.905,"dovitinib, quizartinib, GTP.14564",0.223298816011589,0.0433514207947967,FALSE
+"HCC827","Pearson.est","glucocorticoid receptor agonist",-0.36645,-0.924,0.521,959,0.829,"desonide, clobetasol.propionate, triamcinolone, fludroxycortide, dexamethasone.acetate, ciclesonide, prednisolone.acetate, prednisolone.hemisuccinate, beclomethasone.dipropionate, flumethasone.pivalate, flumethasone, fluorometholone, fluocinolone.acetonide",0.283162276700476,0.0814454694497265,FALSE
+"HCC827","Pearson.est","glutamate receptor antagonist",0.44688,1.17,0.306,247,0.828,"ACDPP, kynurenic.acid, felbamate, IEM1754, CGP.37849",0.51427857351842,0.0819696632151199,FALSE
+"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.22717,-0.589,0.923,1020,0.973,"GSK.3.inhibitor.IX, CHIR.98014, kenpaullone, LY2090314",0.0347982989740879,0.0118871597316481,FALSE
+"HCC827","Pearson.est","growth factor receptor inhibitor",-0.53767,-1.39,0.129,1237,0.556,"AZD3463, GSK1904529A, GSK1838705A, PHA.848125",0.889410289700751,0.254925208417942,FALSE
+"HCC827","Pearson.est","HCV inhibitor",-0.46065,-1.19,0.283,1415,0.562,"narlaprevir",0.54821356447571,0.250263684430939,FALSE
+"HCC827","Pearson.est","HDAC inhibitor",-0.3447,-0.892,0.582,1011,0.829,"JNJ.26481585, vorinostat, romidepsin, resminostat, chidamide, PCI.24781, AR.42, belinostat, dacinostat, trichostatin.a, panobinostat, RG2833, mocetinostat",0.235077015350112,0.0814454694497265,FALSE
+"HCC827","Pearson.est","histamine receptor antagonist",-0.24671,-0.641,0.892,1010,0.976,"cimetidine, terfenadine, nizatidine, tiotidine, pheniramine, cyproheptadine, famotidine",0.0496351456238769,0.0105501823333082,FALSE
+"HCC827","Pearson.est","HMGCR inhibitor",0.40361,1.04,0.386,866,0.829,"atorvastatin, lovastatin, pitavastatin, mevastatin, fluvastatin, simvastatin",0.413412695328245,0.0814454694497265,FALSE
+"HCC827","Pearson.est","HSP inhibitor",0.58742,1.54,0.0755,434,0.349,"NMS.E973, BIIB021, XL888, SNX.2112, VER.49009, alvespimycin, NVP.AUY922, tanespimycin, KW.2478, SNX.5422, guanidine",1.12205304837081,0.45717457304082,FALSE
+"HCC827","Pearson.est","JAK inhibitor",-0.2258,-0.58,0.934,1120,0.956,"filgotinib, tozasertib, TG.101209, pacritinib, CEP.33779",0.0296531237699066,0.0195421077238999,FALSE
+"HCC827","Pearson.est","KIT inhibitor",0.24638,0.643,0.892,182,0.944,"lenvatinib, imatinib, pazopanib, motesanib",0.0496351456238769,0.025028005701931,FALSE
+"HCC827","Pearson.est","MDM inhibitor",0.78617,2.04,0.00395,95,0.11,"AMG.232, idasanutlin, nutlin.3, CGM097",2.40340290437354,0.958607314841775,TRUE
+"HCC827","Pearson.est","MEK inhibitor",-0.75641,-1.92,0.00378,1240,0.143,"PD.318088, PD.0325901, BIX.02188, TAK.733, Ro.4987655, AS.703026, MEK162, selumetinib, AZD8330, nobiletin, refametinib, PD.184352, cobimetinib, trametinib",2.42250820016277,0.844663962534938,TRUE
+"HCC827","Pearson.est","MET inhibitor",-0.62207,-1.63,0.0494,1038,0.492,"NVP.BVU972, PF.04217903, PHA.665752, LY2801653",1.30627305107635,0.30803489723264,FALSE
+"HCC827","Pearson.est","microtubule inhibitor",0.19727,0.533,0.97,77,0.987,"triclabendazole",0.0132282657337552,0.00568284733036327,FALSE
+"HCC827","Pearson.est","mTOR inhibitor",0.57691,1.47,0.0971,302,0.42,"sirolimus, PF.05212384, PKI.179, WYE.125132, OSI.027, PI.103, torin.1, deforolimus, everolimus, PP242, temsirolimus, XL388, torin.2, AZD8055, ku.0063794, voxtalisib",1.012780770092,0.3767507096021,FALSE
+"HCC827","Pearson.est","NFkB pathway inhibitor",0.34512,0.907,0.543,180,0.918,"EVP4593, parthenolide...., BAY.11.7082",0.265200170411153,0.0371573187987575,FALSE
+"HCC827","Pearson.est","opioid receptor agonist",-0.23064,-0.593,0.909,1118,0.995,"BW.180C, trimebutine",0.0414361167780325,0.00217691925427455,FALSE
+"HCC827","Pearson.est","p38 MAPK inhibitor",0.26913,0.703,0.821,92,0.919,"skepinone.l",0.0856568428805592,0.0366844886138887,FALSE
+"HCC827","Pearson.est","PARP inhibitor",0.60925,1.61,0.0556,319,0.381,"niraparib, PJ.34, AZD2461, talazoparib, AG.14361",1.25492520841794,0.419075024324381,FALSE
+"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.37573,0.992,0.416,295,0.892,"dovitinib, lenvatinib, linifanib, imatinib, trapidil, pazopanib, motesanib, axitinib, nintedanib, sunitinib",0.380906669373257,0.0496351456238769,FALSE
+"HCC827","Pearson.est","phosphatase inhibitor",0.35765,0.92,0.524,28,0.928,"mycophenolate.mofetil",0.280668713016273,0.0324520237811379,FALSE
+"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.28225,-0.714,0.795,1417,0.961,"YM.976",0.0996328713435297,0.0172766123314547,FALSE
+"HCC827","Pearson.est","PI3K inhibitor",0.35056,0.904,0.557,302,0.888,"PF.05212384, PKI.179, PI.103, PI.828, BGT226, buparlisib, idelalisib, voxtalisib",0.254144804826271,0.051587034221399,FALSE
+"HCC827","Pearson.est","PLK inhibitor",0.31442,0.813,0.697,532,0.88,"HMN.214, rigosertib, GSK461364, NMS.1286937, GW.843682X",0.156767221901991,0.0555173278498314,FALSE
+"HCC827","Pearson.est","potassium channel blocker",-0.47438,-1.26,0.2,1368,0.54,"oleoylethanolamide, meglitinide",0.698970004336019,0.267606240177031,FALSE
+"HCC827","Pearson.est","PPAR receptor agonist",0.31971,0.847,0.609,173,0.874,"ciprofibrate, clofibrate",0.215382707367125,0.058488567365597,FALSE
+"HCC827","Pearson.est","progesterone receptor agonist",-0.24861,-0.65,0.865,930,1,"nomegestrol.acetate, norethindrone.acetate, danazol, levonorgestrel, melengestrol.acetate, dienogest",0.0629838925351858,0,FALSE
+"HCC827","Pearson.est","proteasome inhibitor",-0.24627,-0.641,0.862,1212,0.976,"bortezomib, ixazomib",0.0644927341752872,0.0105501823333082,FALSE
+"HCC827","Pearson.est","protein synthesis inhibitor",0.71363,1.86,0.0237,204,0.258,"homoharringtonine, bruceantin, cycloheximide, clofoctol, anguidine, harringtonine, azomycin..2.nitroimidazole., methacycline",1.6252516539899,0.58838029403677,FALSE
+"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.42589,-1.11,0.309,1335,0.609,"rheochrysidin, NVP.TAE226, BMS.599626",0.510041520575165,0.215382707367125,FALSE
+"HCC827","Pearson.est","RAF inhibitor",0.30153,0.782,0.718,1015,0.905,"SB.590885, sorafenib, regorafenib, CEP.32496, LGX818, AZ.628, dabrafenib, GDC.0879, RAF265, TAK.632, PLX.4720, vemurafenib",0.1438755557577,0.0433514207947967,FALSE
+"HCC827","Pearson.est","RET tyrosine kinase inhibitor",0.40245,1.08,0.352,398,0.831,"apatinib, cabozantinib, sunitinib, sorafenib, regorafenib",0.453457336521869,0.080398976215889,FALSE
+"HCC827","Pearson.est","retinoid receptor agonist",0.54743,1.43,0.129,371,0.443,"fenretinide, adarotene, LE.135, adapalene, bexarotene",0.889410289700751,0.35359627377693,FALSE
+"HCC827","Pearson.est","ribonucleotide reductase inhibitor",0.17392,0.453,0.996,107,0.99,"LY2334737",0.00174066157630127,0.00436480540245009,FALSE
+"HCC827","Pearson.est","serotonin receptor agonist",-0.69495,-1.76,0.0202,1447,0.303,"aripiprazole",1.69464863055338,0.518557371497695,FALSE
+"HCC827","Pearson.est","serotonin receptor antagonist",-0.473,-1.2,0.261,1413,0.576,"RS.16566, aripiprazole",0.583359492661719,0.239577516576788,FALSE
+"HCC827","Pearson.est","sodium channel blocker",0.40495,1.07,0.36,119,0.809,"benzethonium, benzocaine",0.443697499232713,0.0920514783877277,FALSE
+"HCC827","Pearson.est","src inhibitor",-0.57138,-1.49,0.0885,1324,0.474,"PP.1, bosutinib, dasatinib",1.05305672930217,0.324221658325915,FALSE
+"HCC827","Pearson.est","sterol demethylase inhibitor",0.64518,1.72,0.0384,110,0.322,"chlormidazole, posaconazole, lanoconazole",1.41566877563247,0.492144128304169,FALSE
+"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.32684,-0.859,0.621,1124,0.831,"D.4476, repsox, SB.431542",0.20690839982342,0.080398976215889,FALSE
+"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.4126,-1.06,0.354,1377,0.667,"capecitabine",0.450996737974212,0.175874166083451,FALSE
+"HCC827","Pearson.est","topoisomerase inhibitor",0.32081,0.832,0.657,240,0.873,"doxorubicin, epirubicin, mitoxantrone, etoposide.phosphate, idarubicin, valrubicin, amonafide, nemorubicin, daunorubicin",0.182434630440219,0.0589857562944303,FALSE
+"HCC827","Pearson.est","tubulin polymerization inhibitor",0.4528,1.15,0.287,457,0.818,"mebendazole, fenbendazole, vincristine, dolastatin.10, taltobulin, vindesine, parbendazole, indibulin, nocodazole, BNC105, combretastatin.A.4, CYT.997, podophyllotoxin, verubulin, vinblastine, vinorelbine",0.542118103266008,0.087246696328677,FALSE
+"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.3844,-1,0.441,1335,0.718,"rheochrysidin, NVP.TAE226, aminopurvalanol.a, BMS.599626, vandetanib, dasatinib",0.355561410532161,0.1438755557577,FALSE
+"HCC827","Pearson.est","VEGFR inhibitor",0.37845,0.974,0.46,295,0.89,"dovitinib, PD.173074, lenvatinib, linifanib, tivozanib, pazopanib, golvatinib, motesanib, axitinib, MGCD.265, nintedanib, TG.100572, cabozantinib, sunitinib",0.337242168318426,0.0506099933550872,FALSE
+"HCC827","Pearson.est","vitamin D receptor agonist",-0.54553,-1.41,0.151,956,0.575,"alfacalcidol, maxacalcitol, doxercalciferol, ercalcitriol, tacalcitol",0.821023052706831,0.24033215531037,FALSE
+"CALU3","Pearson.est","EGFR inhibitor",0.25983,0.677,0.855,373,0.937,"PD.168393, poziotinib, WZ.3146, AST.1306, CP.724714, CGP.52411, tyrphostin.AG.1478, CNX.2006, canertinib, pelitinib, afatinib, brigatinib, WZ.4002, erlotinib",0.0680338852718274,0.0282604091122217,FALSE
+"CALU3","Pearson.est","Abl kinase inhibitor",-0.55187,-1.43,0.114,1207,0.355,"imatinib, tozasertib, KW.2449, ponatinib, bafetinib",0.943095148663527,0.449771646944906,FALSE
+"CALU3","Pearson.est","acetylcholine receptor agonist",0.42007,1.07,0.374,387,0.79,"xanomeline, oxiracetam, tremorine",0.42712839779952,0.102372908709559,FALSE
+"CALU3","Pearson.est","acetylcholine receptor antagonist",0.34091,0.871,0.611,443,0.877,"hyoscyamine, diphemanil, darifenacin",0.213958789757446,0.0570004066339595,FALSE
+"CALU3","Pearson.est","adenosine receptor antagonist",-0.36764,-0.956,0.503,1237,0.636,"istradefylline, CGS.15943",0.298432014944073,0.196542884351586,FALSE
+"CALU3","Pearson.est","adrenergic receptor agonist",0.28011,0.713,0.808,272,0.941,"lidamidine, xylazine, oxymetazoline, methyldopa, epinephrine",0.0925886392254138,0.0264103765727431,FALSE
+"CALU3","Pearson.est","adrenergic receptor antagonist",0.3853,0.978,0.474,156,0.871,"RS.17053, prazosin, imiloxan",0.324221658325915,0.0599818449923368,FALSE
+"CALU3","Pearson.est","AKT inhibitor",-0.46821,-1.23,0.22,1131,0.452,"uprosertib, A.674563, ONC201, triciribine, MK.2206",0.657577319177794,0.344861565188618,FALSE
+"CALU3","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33123,-0.859,0.604,1330,0.727,"crizotinib, DMH1, CEP.37440",0.218963061378868,0.138465589140962,FALSE
+"CALU3","Pearson.est","androgen receptor antagonist",-0.35028,-0.908,0.53,1104,0.692,"RU.58841, bicalutamide, cyproterone.acetate",0.275724130399211,0.159893905543242,FALSE
+"CALU3","Pearson.est","antioxidant",-0.56815,-1.53,0.0814,1262,0.334,"chlorogenic.acid, trolox, taurine",1.0893755951108,0.476253533188435,FALSE
+"CALU3","Pearson.est","AP inhibitor",0.75034,1.89,0.00351,187,0.157,"tanshinone.i, birinapant, GDC.0152",2.45469288353418,0.804100347590766,TRUE
+"CALU3","Pearson.est","ATPase inhibitor",0.4484,1.12,0.314,251,0.93,"ouabain, rabeprazole, NMS.873, digitoxin, k.strophanthidin",0.503070351926785,0.0315170514460649,FALSE
+"CALU3","Pearson.est","Aurora kinase inhibitor",0.34857,0.888,0.578,356,0.908,"PHA.680632, danusertib, TAK.901, CYC116, barasertib.HQPA, GSK1070916, MLN.8054, CCT129202, ZM.447439",0.238072161579471,0.0419141514789149,FALSE
+"CALU3","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.47106,-1.24,0.203,1162,0.46,"dirithromycin, azithromycin, valnemulin",0.692503962086787,0.337242168318426,FALSE
+"CALU3","Pearson.est","bacterial DNA gyrase inhibitor",0.54973,1.38,0.141,263,0.632,"lomefloxacin, norfloxacin, trovafloxacin, finafloxacin",0.85078088734462,0.199282921717615,FALSE
+"CALU3","Pearson.est","BCL inhibitor",-0.60792,-1.59,0.0583,1294,0.32,"venetoclax, TW.37, gossypol",1.23433144524099,0.494850021680094,FALSE
+"CALU3","Pearson.est","Bcr.Abl kinase inhibitor",-0.60301,-1.59,0.0603,1207,0.32,"imatinib, tozasertib, ponatinib, bafetinib",1.21968268785985,0.494850021680094,FALSE
+"CALU3","Pearson.est","benzodiazepine receptor agonist",0.32703,0.811,0.681,308,0.867,"gamma.aminobutyric.acid, CL.218872, bentazepam, ZK.93423",0.166852888087215,0.0619809025237897,FALSE
+"CALU3","Pearson.est","bromodomain inhibitor",-0.65,-1.77,0.0259,954,0.333,"I.BET151, PFI.1, OTX015, JQ1...., bromosporine",1.58670023591875,0.47755576649368,FALSE
+"CALU3","Pearson.est","calcium channel blocker",-0.42748,-1.14,0.266,1247,0.518,"cinnarazine, SR.33805, carboxyamidotriazole, penfluridol",0.575118363368933,0.285670240254767,FALSE
+"CALU3","Pearson.est","CC chemokine receptor antagonist",-0.40932,-1.07,0.373,1311,0.581,"navarixin, RS.504393",0.428291168191312,0.235823867609669,FALSE
+"CALU3","Pearson.est","CDK inhibitor",-0.50937,-1.34,0.162,1157,0.376,"P276.00, indirubin, dinaciclib, PHA.848125, TG.02, NU6027, alvocidib, AZD5438, palbociclib, abemaciclib, kenpaullone",0.790484985457369,0.424812155072339,FALSE
+"CALU3","Pearson.est","CHK inhibitor",0.45983,1.17,0.27,226,0.939,"PF.477736, AZD7762",0.568636235841013,0.0273344077338891,FALSE
+"CALU3","Pearson.est","cyclooxygenase inhibitor",0.25438,0.649,0.882,123,0.944,"AM.404, naproxen, amfenac, metoxibutropate",0.0545314148681803,0.025028005701931,FALSE
+"CALU3","Pearson.est","cytochrome P450 inhibitor",0.57243,1.45,0.115,231,0.863,"PF.4981517, eplerenone, morin",0.939302159646388,0.0639892042847904,FALSE
+"CALU3","Pearson.est","DNA alkylating agent",-0.40343,-1.06,0.366,1134,0.575,"ifosfamide, cisplatin, melphalan, mitomycin.c, estramustine, carmustine",0.436518914605589,0.24033215531037,FALSE
+"CALU3","Pearson.est","DNA inhibitor",0.25197,0.639,0.891,445,0.907,"sangivamycin, tirapazamine, busulfan, nimorazole, bendamustine, carboplatin, nithiamide, mechlorethamine, valrubicin",0.0501222959631252,0.0423927129399047,FALSE
+"CALU3","Pearson.est","DNA methyltransferase inhibitor",-0.32767,-0.848,0.61,1008,0.723,"azacitidine, RG108, decitabine",0.214670164989233,0.140861702705469,FALSE
+"CALU3","Pearson.est","DNA polymerase inhibitor",0.3851,0.971,0.475,174,0.848,"famciclovir, cephalomannine, cidofovir",0.323306390375133,0.0716041477432862,FALSE
+"CALU3","Pearson.est","DNA synthesis inhibitor",-0.29948,-0.786,0.674,1132,0.777,"enocitabine, cisplatin, mitomycin.c, anisomycin, artesunate",0.17134010346468,0.109578981199086,FALSE
+"CALU3","Pearson.est","dopamine receptor antagonist",0.41912,1.08,0.344,306,0.811,"remoxipride, ziprasidone, clebopride, isofloxythepin, thioproperazine, UH.232...., domperidone",0.46344155742847,0.090979145788844,FALSE
+"CALU3","Pearson.est","estrogen receptor agonist",0.4296,1.11,0.32,323,0.893,"erteberel, levonorgestrel, estradiol.cypionate, equol, ethinyl.estradiol",0.494850021680094,0.0491485411114536,FALSE
+"CALU3","Pearson.est","estrogen receptor antagonist",0.46027,1.18,0.275,173,0.994,"tamoxifen, raloxifene",0.560667306169737,0.00261361560268669,FALSE
+"CALU3","Pearson.est","FGFR inhibitor",-0.55715,-1.47,0.107,1024,0.329,"nintedanib, MK.2461, lucitanib, erdafitinib, regorafenib",0.97061622231479,0.482804102050026,FALSE
+"CALU3","Pearson.est","FLT3 inhibitor",-0.56232,-1.51,0.0974,1096,0.333,"ENMD.2076, sunitinib, TG.02, tozasertib, KW.2449, quizartinib, pacritinib, ponatinib, sorafenib",1.01144104312138,0.47755576649368,FALSE
+"CALU3","Pearson.est","glucocorticoid receptor agonist",0.74322,1.9,0.00684,352,0.288,"hydrocortisone, halcinonide, dexamethasone.acetate, fluticasone.propionate, fluorometholone, flumethasone.pivalate, prednisolone, betamethasone, fluocinolone.acetonide, triamcinolone.acetonide, ciclesonide, triamcinolone, prednisolone.acetate, desonide, clobetasol.propionate, fludroxycortide, deflazacort, methylprednisolone, rimexolone, halobetasol.propionate, piretanide, difluprednate",2.16494389827988,0.540607512240769,FALSE
+"CALU3","Pearson.est","glutamate receptor antagonist",0.55284,1.44,0.107,284,0.752,"CPP, kynurenic.acid, IEM1754, CGP.37849, latrepirdine, JNJ.16259685, LY456236",0.97061622231479,0.123782159408358,FALSE
+"CALU3","Pearson.est","glycogen synthase kinase inhibitor",-0.3985,-1.03,0.404,1066,0.58,"AZD2858, LY2090314, indirubin, GSK.3.inhibitor.IX, kenpaullone",0.393618634889395,0.236572006437063,FALSE
+"CALU3","Pearson.est","growth factor receptor inhibitor",0.45468,1.14,0.303,169,0.946,"danusertib, GSK1904529A",0.518557371497695,0.0241088635982073,FALSE
+"CALU3","Pearson.est","HCV inhibitor",-0.54478,-1.42,0.124,1193,0.323,"daclatasvir, Ro.9187",0.906578314837765,0.490797477668897,FALSE
+"CALU3","Pearson.est","HDAC inhibitor",-0.60471,-1.62,0.0432,1182,0.373,"mocetinostat, scriptaid, vorinostat, chidamide, PCI.24781, trichostatin.a, givinostat, panobinostat, belinostat, dacinostat, entinostat, R306465, AR.42, M.344, resminostat, RG2833",1.36451625318509,0.428291168191312,FALSE
+"CALU3","Pearson.est","histamine receptor antagonist",0.30225,0.782,0.725,428,0.889,"zolantidine, ebastine, ICI.162846, ranitidine, levocetirizine, epinastine, chloropyramine, pheniramine, astemizole",0.139661993429006,0.0510982390297863,FALSE
+"CALU3","Pearson.est","HMGCR inhibitor",0.55647,1.39,0.124,84,0.684,"fluvastatin, mevastatin",0.906578314837765,0.164943898279884,FALSE
+"CALU3","Pearson.est","HSP inhibitor",0.34382,0.868,0.617,219,0.824,"KW.2478, PU.H71, SNX.2112",0.209714835966758,0.0840727883028842,FALSE
+"CALU3","Pearson.est","JAK inhibitor",-0.25379,-0.678,0.836,1216,0.842,"TG.02, tozasertib, TG.101209, pacritinib",0.0777937225609836,0.0746879085003505,FALSE
+"CALU3","Pearson.est","KIT inhibitor",-0.50222,-1.3,0.183,1385,0.402,"KI.8751, pazopanib, telatinib, sorafenib, regorafenib",0.737548910269571,0.39577394691553,FALSE
+"CALU3","Pearson.est","MDM inhibitor",0.30791,0.777,0.75,1004,0.871,"CGM097, AMG.232, idasanutlin, nutlin.3, serdemetan, RITA",0.1249387366083,0.0599818449923368,FALSE
+"CALU3","Pearson.est","MEK inhibitor",0.2591,0.643,0.875,230,0.926,"PD.198306, Ro.4987655, MEK1.2.inhibitor, PD.318088",0.0579919469776868,0.0333890133180656,FALSE
+"CALU3","Pearson.est","MET inhibitor",-0.69529,-1.81,0.0194,1174,0.392,"AMG458, NVP.BVU972, LY2801653",1.71219827006977,0.406713932979543,FALSE
+"CALU3","Pearson.est","microtubule inhibitor",0.41321,1.05,0.381,642,0.793,"cabazitaxel, vinblastine, colchicine, triclabendazole, podophyllotoxin, cytochalasin.b, secnidazole, vinflunine",0.419075024324381,0.100726812682396,FALSE
+"CALU3","Pearson.est","mTOR inhibitor",-0.53121,-1.42,0.114,1058,0.323,"XL388, LY3023414, torin.1, PP242, torin.2, AZD2014, GSK2126458, sirolimus, everolimus, SB.2343, WYE.354, WYE.125132, temsirolimus, GDC.0980, NVP.BEZ235, MLN0128",0.943095148663527,0.490797477668897,FALSE
+"CALU3","Pearson.est","NFkB pathway inhibitor",-0.32962,-0.863,0.587,1412,0.742,"betulinic.acid, bortezomib",0.231361898752386,0.129596094720973,FALSE
+"CALU3","Pearson.est","opioid receptor agonist",0.38553,1.02,0.425,91,0.819,"spiradoline",0.371611069949688,0.0867160982395816,FALSE
+"CALU3","Pearson.est","p38 MAPK inhibitor",0.26787,0.693,0.833,1062,0.942,"CMPD.1, SB.239063, TAK.715, skepinone.l, VX.702, SB.242235, talmapimod",0.0793549985932124,0.0259490972071227,FALSE
+"CALU3","Pearson.est","PARP inhibitor",-0.38043,-0.982,0.465,1204,0.635,"endo.IWR.1, E7449",0.332547047110046,0.197226274708024,FALSE
+"CALU3","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.58673,-1.57,0.0539,1130,0.313,"sunitinib, motesanib, CP.673451, imatinib, crenolanib, trapidil, KI.8751, pazopanib, ponatinib, telatinib, sorafenib, regorafenib",1.26841123481326,0.504455662453552,FALSE
+"CALU3","Pearson.est","phosphatase inhibitor",-0.5206,-1.37,0.128,1209,0.359,"BVT.948, bis.maltolato.oxovanadium.IV., alexidine, GSK2830371",0.892790030352132,0.444905551421681,FALSE
+"CALU3","Pearson.est","phosphodiesterase inhibitor",0.32422,0.817,0.66,152,0.885,"cilostamide, trequinsin, papaverine",0.180456064458131,0.0530567293021746,FALSE
+"CALU3","Pearson.est","PI3K inhibitor",-0.28277,-0.734,0.769,1065,0.793,"TG.100713, LY3023414, buparlisib, GSK2126458, ZSTK.474, BGT226, SB.2343, TG100.115, GDC.0980, PI3K.IN.2, NVP.BEZ235",0.114073660198569,0.100726812682396,FALSE
+"CALU3","Pearson.est","PLK inhibitor",0.54712,1.4,0.124,60,0.754,"HMN.214, NMS.1286937",0.906578314837765,0.122628654130226,FALSE
+"CALU3","Pearson.est","potassium channel blocker",0.42019,1.08,0.364,32,0.811,"meglitinide",0.438898616350944,0.090979145788844,FALSE
+"CALU3","Pearson.est","PPAR receptor agonist",-0.30326,-0.782,0.684,437,0.764,"ciprofibrate, GW.501516, S26948, fenofibrate, clofibrate, pterostilbene, oleoylethanolamide",0.164943898279884,0.11690664142431,FALSE
+"CALU3","Pearson.est","progesterone receptor agonist",0.35669,0.875,0.597,456,0.901,"levonorgestrel, tanaproget, danazol, norgestrel, dienogest",0.224025668870631,0.045275209020937,FALSE
+"CALU3","Pearson.est","proteasome inhibitor",-0.40953,-1.07,0.351,1422,0.581,"bortezomib",0.454692883534176,0.235823867609669,FALSE
+"CALU3","Pearson.est","protein synthesis inhibitor",0.36677,0.937,0.522,167,0.88,"puromycin, clofoctol, chloramphenicol.palmitate, bruceantin, cycloheximide",0.282329496997738,0.0555173278498314,FALSE
+"CALU3","Pearson.est","protein tyrosine kinase inhibitor",0.34834,0.894,0.565,190,0.934,"AV.412, PP.121, CP.724714",0.247951552180562,0.0296531237699066,FALSE
+"CALU3","Pearson.est","RAF inhibitor",-0.60907,-1.64,0.0586,1267,0.407,"TAK.632, dabrafenib, sorafenib, regorafenib, SB.590885",1.23210238398191,0.39040559077478,FALSE
+"CALU3","Pearson.est","RET tyrosine kinase inhibitor",-0.72827,-1.89,0.00879,1390,0.451,"vandetanib, sorafenib, regorafenib",2.05601112492623,0.345823458122039,FALSE
+"CALU3","Pearson.est","retinoid receptor agonist",-0.56984,-1.49,0.0952,1113,0.33,"CD.437, tamibarotene, AM.580, fenretinide",1.02136305161553,0.481486060122112,FALSE
+"CALU3","Pearson.est","ribonucleotide reductase inhibitor",-0.28844,-0.748,0.759,1149,0.794,"hydroxyurea, clofarabine, fludarabine",0.11975822410452,0.100179497572904,FALSE
+"CALU3","Pearson.est","serotonin receptor agonist",0.49654,1.24,0.228,9,0.911,"aripiprazole",0.642065152999546,0.0404816230270017,FALSE
+"CALU3","Pearson.est","serotonin receptor antagonist",0.42996,1.08,0.364,54,0.811,"aripiprazole, ziprasidone",0.438898616350944,0.090979145788844,FALSE
+"CALU3","Pearson.est","sodium channel blocker",-0.35732,-0.975,0.451,1238,0.625,"lappaconite, quinidine, triamterene, butamben, ajmaline",0.345823458122039,0.204119982655925,FALSE
+"CALU3","Pearson.est","src inhibitor",0.24809,0.627,0.899,1091,0.896,"ZM.306416, KX2.391, saracatinib, TG.100572, masitinib, PP.2, bosutinib, dasatinib, PP.1",0.0462403082667712,0.0476919903378748,FALSE
+"CALU3","Pearson.est","sterol demethylase inhibitor",0.34577,0.87,0.576,354,0.849,"lanoconazole, posaconazole",0.239577516576788,0.0710923097560473,FALSE
+"CALU3","Pearson.est","TGF beta receptor inhibitor",0.66184,1.66,0.029,351,0.506,"SB.525334, D.4476, repsox",1.53760200210104,0.295849483160201,FALSE
+"CALU3","Pearson.est","thymidylate synthase inhibitor",-0.44963,-1.21,0.221,1038,0.457,"trifluridine, carmofur, raltitrexed, doxifluridine",0.655607726314889,0.34008379993015,FALSE
+"CALU3","Pearson.est","topoisomerase inhibitor",-0.31403,-0.828,0.628,1312,0.734,"beta.lapachone, topotecan, idarubicin, rubitecan, irinotecan",0.202040356262804,0.134303940083929,FALSE
+"CALU3","Pearson.est","tubulin polymerization inhibitor",0.59877,1.53,0.0753,500,0.752,"vincristine, ABT.751, mebendazole, CYT.997, epothilone.b, dolastatin.10, verubulin, indibulin, vinorelbine, paclitaxel, plinabulin, vinblastine, KX2.391, combretastatin.A.4, parbendazole, flubendazole, oxibendazole, BNC105, epothilone.d, podophyllotoxin, vindesine",1.1232050237993,0.123782159408358,FALSE
+"CALU3","Pearson.est","tyrosine kinase inhibitor",-0.39852,-1.05,0.384,1375,0.57,"tyrphostin.A9, vandetanib, sorafenib, regorafenib, bafetinib",0.415668775632469,0.244125144327509,FALSE
+"CALU3","Pearson.est","VEGFR inhibitor",-0.43778,-1.15,0.302,1016,0.525,"RAF265, MGCD.265, nintedanib, AEE788, ENMD.2076, MK.2461, sunitinib, lucitanib, motesanib, golvatinib, tivozanib, KI.8751, vandetanib, pazopanib, telatinib, sorafenib, regorafenib, foretinib",0.519993057042849,0.279840696594043,FALSE
+"CALU3","Pearson.est","vitamin D receptor agonist",-0.65461,-1.72,0.02,1082,0.33,"paricalcitol, maxacalcitol, doxercalciferol, calcitriol, tacalcitol",1.69897000433602,0.481486060122112,FALSE
+"H2009","Pearson.est","EGFR inhibitor",-0.53727,-1.27,0.199,1200,0.597,"gefitinib, OSI.420, lapatinib, vandetanib, AZD8931, BMS.599626, PD.153035, GW.583340, XL.647, afatinib, ARRY.334543, TAK.285, osimertinib, tucatinib, CUDC.101, AST.1306, dacomitinib, neratinib, BIBU.1361",0.701146923590293,0.224025668870631,FALSE
+"H2009","Pearson.est","Abl kinase inhibitor",-0.23781,-0.561,0.948,1009,0.969,"bosutinib, bafetinib, tozasertib, KW.2449",0.0231916626619338,0.0136762229492347,FALSE
+"H2009","Pearson.est","acetylcholine receptor agonist",-0.50287,-1.18,0.255,1252,0.625,"nicotine, pilocarpine",0.593459819566045,0.204119982655925,FALSE
+"H2009","Pearson.est","acetylcholine receptor antagonist",-0.2436,-0.578,0.943,905,0.975,"diphemanil, dicycloverine",0.0254883072626717,0.0109953843014632,FALSE
+"H2009","Pearson.est","adenosine receptor antagonist",-0.49431,-1.18,0.264,1408,0.625,"CGS.15943",0.578396073130169,0.204119982655925,FALSE
+"H2009","Pearson.est","adrenergic receptor agonist",0.29937,0.878,0.581,1019,0.967,"lidamidine, oxymetazoline, epinephrine, xylazine, methyldopa, terbutaline, A61603, metaraminol, ritodrine, midodrine, isoetharine, isoxsuprine, buphenine, clenbuterol, norepinephrine",0.235823867609669,0.0145735259169983,FALSE
+"H2009","Pearson.est","adrenergic receptor antagonist",0.20147,0.582,0.938,124,0.946,"prazosin, imiloxan, practolol, RS.17053",0.0277971616209356,0.0241088635982073,FALSE
+"H2009","Pearson.est","AKT inhibitor",-0.59603,-1.38,0.097,985,0.503,"AZD5363, CCT128930, palomid.529, MK.2206, GDC.0068, A.674563, triciribine, uprosertib",1.01322826573376,0.298432014944073,FALSE
+"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.49555,-1.16,0.273,1227,0.628,"AZD3463, CEP.37440, DMH1",0.563837352959244,0.202040356262804,FALSE
+"H2009","Pearson.est","androgen receptor antagonist",0.42094,1.24,0.194,841,0.592,"flutamide, bicalutamide, nilutamide, cyproterone.acetate, enzalutamide, RU.58841",0.712198270069774,0.22767829327708,FALSE
+"H2009","Pearson.est","antioxidant",0.26075,0.75,0.754,1072,0.87,"rutin, mesna, benfotiamine, chlorogenic.acid, trolox, taurine",0.122628654130226,0.0604807473813815,FALSE
+"H2009","Pearson.est","AP inhibitor",0.40354,1.19,0.249,75,0.599,"birinapant, GDC.0152",0.603800652904264,0.222573177610689,FALSE
+"H2009","Pearson.est","ATPase inhibitor",-0.24781,-0.587,0.943,1042,0.985,"oligomycin.a, NMS.873, evodiamine, digoxin",0.0254883072626717,0.00656376950238827,FALSE
+"H2009","Pearson.est","Aurora kinase inhibitor",-0.57916,-1.37,0.101,1235,0.46,"AT.9283, PF.03814735, tozasertib, barasertib.HQPA, AMG900, MK.8745, KW.2449, SNS.314, ZM.447439, CCT137690, ENMD.2076, hesperadin",0.995678626217357,0.337242168318426,FALSE
+"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.62044,-1.47,0.0676,1029,0.561,"azalomycin.b, valnemulin, tedizolid, radezolid, dirithromycin, azithromycin",1.17005330405836,0.251037138743839,FALSE
+"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.44206,-1.04,0.416,1387,0.739,"nadifloxacin",0.380906669373257,0.131355561605174,FALSE
+"H2009","Pearson.est","BCL inhibitor",-0.65898,-1.52,0.0475,1430,0.483,"TW.37, gossypol",1.32330639037513,0.316052869248488,FALSE
+"H2009","Pearson.est","Bcr.Abl kinase inhibitor",0.29753,0.879,0.632,156,1,"dasatinib, GZD824, metatinib",0.199282921717615,0,FALSE
+"H2009","Pearson.est","benzodiazepine receptor agonist",-0.29387,-0.71,0.819,1311,0.975,"piperazine, ivermectin",0.0867160982395816,0.0109953843014632,FALSE
+"H2009","Pearson.est","bromodomain inhibitor",-0.87725,-2.07,0,1265,0.00753,"I.BET.762, PFI.1, I.BET151, bromosporine, JQ1...., OTX015",Inf,2.1232050237993,TRUE
+"H2009","Pearson.est","calcium channel blocker",-0.52847,-1.23,0.222,1131,0.593,"tetrandrine, SKF.96365, penfluridol, mibefradil, carboxyamidotriazole",0.653647025549361,0.226945306635737,FALSE
+"H2009","Pearson.est","CC chemokine receptor antagonist",-0.46862,-1.1,0.341,1040,0.707,"ZK811752, PF.04136309, navarixin, SB.225002",0.467245621007502,0.150580586203101,FALSE
+"H2009","Pearson.est","CDK inhibitor",-0.59201,-1.41,0.0805,937,0.508,"JNJ.7706621, indirubin, PHA.793887, AZD5438, aminopurvalanol.a, ribociclib, arcyriaflavin.a, R547, BMS.265246, P276.00, dinaciclib, palbociclib, alvocidib, abemaciclib, kenpaullone, BMS.387032, AT.7519, indisulam, TG.02",1.09420411963213,0.294136287716081,FALSE
+"H2009","Pearson.est","CHK inhibitor",-0.26798,-0.633,0.907,1079,0.984,"LY2603618, SB.218078",0.0423927129399047,0.00700490156865849,FALSE
+"H2009","Pearson.est","cyclooxygenase inhibitor",-0.26523,-0.636,0.908,856,1,"FR.122047, naproxen, tepoxalin, meloxicam, aspirin, curcumin, ketoprofen, ramifenazone, tryptanthrin",0.0419141514789149,0,FALSE
+"H2009","Pearson.est","cytochrome P450 inhibitor",0.52486,1.46,0.103,174,0.335,"metyrapone, morin, eplerenone",0.987162775294828,0.474955192963155,FALSE
+"H2009","Pearson.est","DNA alkylating agent",-0.53191,-1.25,0.175,1038,0.622,"streptozotocin, cyclophosphamide, carmustine, TH.302, estramustine, satraplatin, melphalan, mitomycin.c",0.756961951313706,0.206209615309181,FALSE
+"H2009","Pearson.est","DNA inhibitor",-0.35097,-0.823,0.718,917,0.941,"metronidazole, mechlorethamine, oxaliplatin, bendamustine, teroxirone, carmustine, pibenzimol, primaquine, melphalan",0.1438755557577,0.0264103765727431,FALSE
+"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.74668,-1.76,0.00591,1117,0.18,"disulfiram, fdcyd, decitabine, azacitidine",2.22841251911874,0.744727494896694,TRUE
+"H2009","Pearson.est","DNA polymerase inhibitor",-0.40808,-0.947,0.559,970,0.825,"cephalomannine, trifluridine, foscarnet, idoxuridine, adefovir.dipivoxil",0.252588192113577,0.0835460514500749,FALSE
+"H2009","Pearson.est","DNA synthesis inhibitor",-0.45041,-1.05,0.402,1154,0.758,"enocitabine, anisomycin, cyclocytidine, mitomycin.c",0.39577394691553,0.120330794367946,FALSE
+"H2009","Pearson.est","dopamine receptor antagonist",-0.3234,-0.767,0.777,832,0.953,"piperacetazine, amisulpride, domperidone, raclopride, mesoridazine, paliperidone, sertindole, lurasidone",0.109578981199086,0.0209070993616736,FALSE
+"H2009","Pearson.est","estrogen receptor agonist",0.22397,0.647,0.911,42,0.945,"estradiol.cypionate",0.0404816230270017,0.0245681914907371,FALSE
+"H2009","Pearson.est","estrogen receptor antagonist",-0.25916,-0.613,0.92,1328,0.984,"clomifene",0.0362121726544447,0.00700490156865849,FALSE
+"H2009","Pearson.est","FGFR inhibitor",-0.34316,-0.806,0.715,1263,0.93,"lucitanib, regorafenib",0.145693958198919,0.0315170514460649,FALSE
+"H2009","Pearson.est","FLT3 inhibitor",-0.51241,-1.23,0.219,1257,0.593,"tozasertib, pacritinib, KW.2449, sorafenib, ENMD.2076, TG.02",0.659555885159882,0.226945306635737,FALSE
+"H2009","Pearson.est","glucocorticoid receptor agonist",-0.15164,-0.354,1,956,0.999,"difluprednate, triamcinolone.acetonide, prednisolone, beclomethasone.dipropionate, methylprednisolone, prednisolone.hemisuccinate, deflazacort",0,0.000434511774017692,FALSE
+"H2009","Pearson.est","glutamate receptor antagonist",0.5905,1.73,0.0359,159,0.147,"latrepirdine, CGP.37849, JNJ.16259685, kynurenic.acid, SIB.1757, CPP",1.44490555142168,0.832682665251824,TRUE
+"H2009","Pearson.est","glycogen synthase kinase inhibitor",0.2648,0.807,0.741,140,0.893,"CHIR.98014, tideglusib, TWS.119",0.130181792020672,0.0491485411114536,FALSE
+"H2009","Pearson.est","growth factor receptor inhibitor",-0.4331,-1.01,0.468,1209,0.767,"GSK1838705A, AZD3463",0.329754146925876,0.115204636051019,FALSE
+"H2009","Pearson.est","HCV inhibitor",-0.57836,-1.37,0.104,834,0.46,"daclatasvir, PSI.7976, embelin, mericitabine, Ro.9187, narlaprevir",0.98296666070122,0.337242168318426,FALSE
+"H2009","Pearson.est","HDAC inhibitor",-0.6056,-1.42,0.0862,1143,0.585,"vorinostat, pyroxamide, RG2833, chidamide, trichostatin.a, belinostat, givinostat, dacinostat, PCI.24781, resminostat, entinostat, R306465, AR.42, M.344",1.06449273417529,0.23284413391782,FALSE
+"H2009","Pearson.est","histamine receptor antagonist",-0.26866,-0.634,0.903,969,0.999,"pheniramine, chloropyramine, cyproheptadine, BF2.649, tiotidine, astemizole, famotidine, terfenadine",0.0443122496864942,0.000434511774017692,FALSE
+"H2009","Pearson.est","HMGCR inhibitor",0.7871,2.42,0,313,0.0103,"fluvastatin, pitavastatin, simvastatin, atorvastatin, mevastatin, lovastatin",Inf,1.98716277529483,TRUE
+"H2009","Pearson.est","HSP inhibitor",-0.5516,-1.31,0.127,1051,0.553,"PU.H71, XL888, SNX.5422, BIIB021, ganetespib, NVP.AUY922, tanespimycin",0.896196279044043,0.257274868695302,FALSE
+"H2009","Pearson.est","JAK inhibitor",-0.44305,-1.05,0.403,634,0.758,"ruxolitinib, AZ960, filgotinib, WHI.P154, lestaurtinib, PRT062070, TG.101348, CEP.33779, atiprimod, baricitinib, AZD1480, LY2784544, AT.9283, tozasertib, pacritinib, TG.101209, TG.02",0.39469495385889,0.120330794367946,FALSE
+"H2009","Pearson.est","KIT inhibitor",-0.39907,-0.939,0.545,1152,0.804,"tandutinib, pazopanib, OSI.930, regorafenib, sorafenib",0.263603497723358,0.0947439512515487,FALSE
+"H2009","Pearson.est","MDM inhibitor",0.69271,1.92,0.027,97,0.0928,"idasanutlin, AMG.232, CGM097, nutlin.3",1.56863623584101,1.03245202378114,TRUE
+"H2009","Pearson.est","MEK inhibitor",-0.42005,-0.985,0.489,1094,0.784,"arctigenin, cobimetinib, AZD8330, MEK162, PD.184352, AS.703026, nobiletin, trametinib",0.31069114087638,0.105683937315562,FALSE
+"H2009","Pearson.est","MET inhibitor",-0.29327,-0.697,0.841,875,0.973,"LY2801653, INC.280, NVP.BVU972",0.0752040042020878,0.0118871597316481,FALSE
+"H2009","Pearson.est","microtubule inhibitor",-0.40087,-0.956,0.522,947,0.827,"cabazitaxel, vinflunine, cytochalasin.b, D.64131",0.282329496997738,0.0824944904474534,FALSE
+"H2009","Pearson.est","mTOR inhibitor",-0.33066,-0.768,0.776,619,0.97,"PF.05212384, OSI.027, everolimus, LY3023414, SB.2343, PF.04691502, WYE.354, NVP.BEZ235, voxtalisib, PP242, XL388, temsirolimus, AZD2014, AZD8055, palomid.529, MLN0128, WYE.125132, ku.0063794, torin.2, GDC.0980, GSK2126458",0.110138278741812,0.0132282657337552,FALSE
+"H2009","Pearson.est","NFkB pathway inhibitor",-0.50313,-1.19,0.241,838,0.649,"parthenolide, Ro.106.9920, parthenolide...., tyloxapol, curcumin, EVP4593, bortezomib, betulinic.acid",0.617982957425132,0.187755303199631,FALSE
+"H2009","Pearson.est","opioid receptor agonist",0.29907,0.829,0.648,130,0.915,"spiradoline, BW.180C",0.188424994129407,0.0385789059335517,FALSE
+"H2009","Pearson.est","p38 MAPK inhibitor",-0.55195,-1.3,0.175,974,0.547,"VX.702, SB.239063, SB.242235, talmapimod",0.756961951313706,0.262012673666569,FALSE
+"H2009","Pearson.est","PARP inhibitor",-0.49801,-1.17,0.274,1023,0.626,"PJ.34, talazoparib, niraparib, olaparib",0.562249437179612,0.20342566678957,FALSE
+"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.31273,-0.741,0.812,1093,0.954,"crenolanib, tandutinib, pazopanib, CP.673451, trapidil, regorafenib, sorafenib",0.0904439707588247,0.0204516252959049,FALSE
+"H2009","Pearson.est","phosphatase inhibitor",-0.43324,-1.01,0.465,1401,0.767,"mycophenolic.acid, mycophenolate.mofetil",0.332547047110046,0.115204636051019,FALSE
+"H2009","Pearson.est","phosphodiesterase inhibitor",0.35656,1.01,0.421,192,0.927,"anagrelide, enoximone, papaverine",0.375717904164332,0.0329202658555029,FALSE
+"H2009","Pearson.est","PI3K inhibitor",-0.4212,-0.997,0.469,1123,0.777,"CUDC.907, PI3K.IN.2, buparlisib, TG.100713, CH5132799, taselisib, GDC.0980, GSK2126458, alpelisib",0.328827157284917,0.109578981199086,FALSE
+"H2009","Pearson.est","PLK inhibitor",-0.59733,-1.41,0.0843,897,0.508,"GSK461364, NMS.1286937, rigosertib, GW.843682X, BI.2536, volasertib",1.07417242537526,0.294136287716081,FALSE
+"H2009","Pearson.est","potassium channel blocker",0.30919,0.882,0.588,138,1,"meglitinide, dofetilide",0.230622673923862,0,FALSE
+"H2009","Pearson.est","PPAR receptor agonist",-0.5831,-1.35,0.103,1027,0.482,"clofibrate, ciprofibrate, oleoylethanolamide",0.987162775294828,0.31695296176115,FALSE
+"H2009","Pearson.est","progesterone receptor agonist",-0.38965,-0.925,0.577,1327,0.797,"dienogest, melengestrol.acetate",0.238824186844269,0.0985416786038876,FALSE
+"H2009","Pearson.est","proteasome inhibitor",-0.50993,-1.21,0.242,1303,0.621,"carfilzomib, bortezomib",0.616184634019569,0.20690839982342,FALSE
+"H2009","Pearson.est","protein synthesis inhibitor",-0.31963,-0.755,0.801,878,0.952,"brefeldin.a, puromycin, clindamycin.phosphate, tedizolid.phosphate, harringtonine, thiostrepton, bruceantin, anguidine, homoharringtonine",0.0963674839157623,0.0213630516155257,FALSE
+"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.5363,-1.24,0.191,979,0.621,"mubritinib, AV.412, BMS.599626, NVP.TAE226, tyrphostin.A9",0.718966632752272,0.20690839982342,FALSE
+"H2009","Pearson.est","RAF inhibitor",-0.64891,-1.54,0.045,1118,0.503,"RAF265, SB.590885, AZ.628, GDC.0879, TAK.632, regorafenib, sorafenib",1.34678748622466,0.298432014944073,FALSE
+"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.6588,-1.55,0.0396,1239,0.784,"vandetanib, regorafenib, sorafenib",1.40230481407449,0.105683937315562,FALSE
+"H2009","Pearson.est","retinoid receptor agonist",-0.66612,-1.54,0.043,1272,0.503,"bexarotene, fenretinide, tamibarotene, adarotene",1.36653154442041,0.298432014944073,FALSE
+"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.45565,-1.06,0.372,1208,0.781,"fludarabine, clofarabine",0.429457060118102,0.1073489661227,FALSE
+"H2009","Pearson.est","serotonin receptor agonist",-0.36885,-0.872,0.646,1222,0.876,"zolmitriptan",0.189767482004916,0.0574958938319193,FALSE
+"H2009","Pearson.est","serotonin receptor antagonist",-0.4334,-1.04,0.428,1180,0.739,"SB.228357, paliperidone, sertindole, lurasidone",0.368556230986828,0.131355561605174,FALSE
+"H2009","Pearson.est","sodium channel blocker",-0.34658,-0.817,0.697,927,0.932,"brivaracetam, quinidine, A.803467, lappaconite, triamterene, ajmaline, benzethonium",0.156767221901991,0.0305840876460186,FALSE
+"H2009","Pearson.est","src inhibitor",0.30438,0.854,0.578,1010,0.937,"dasatinib, saracatinib, masitinib, PP.2, ZM.306416, TG.100572, KX2.391, PP.1, bosutinib",0.238072161579471,0.0282604091122217,FALSE
+"H2009","Pearson.est","sterol demethylase inhibitor",0.73343,1.99,0.0137,190,0.106,"lanoconazole, posaconazole, terconazole",1.86327943284359,0.97469413473523,TRUE
+"H2009","Pearson.est","TGF beta receptor inhibitor",0.26422,0.755,0.796,1067,0.92,"SB.525334, adaprev, SB.431542, repsox, LY2109761, D.4476",0.0990869322623309,0.0362121726544447,FALSE
+"H2009","Pearson.est","thymidylate synthase inhibitor",-0.6042,-1.43,0.0932,898,0.621,"ftorafur, trifluridine, doxifluridine, carmofur, raltitrexed",1.03058408764602,0.20690839982342,FALSE
+"H2009","Pearson.est","topoisomerase inhibitor",-0.49235,-1.15,0.285,788,0.629,"licochalcone.a, nemorubicin, amonafide, daunorubicin, voreloxin, etoposide, camptothecin, TAS.103, amsacrine, SN.38, etoposide.phosphate, doxorubicin, fleroxacin, idarubicin, beta.lapachone, irinotecan, topotecan, rubitecan, genz.644282, exatecan.mesylate",0.54515513999149,0.201349354554731,FALSE
+"H2009","Pearson.est","tubulin polymerization inhibitor",-0.39577,-0.941,0.561,874,0.818,"KX2.391, epothilone.d, vindesine, parbendazole, vinorelbine, paclitaxel, fenbendazole, nocodazole, fosbretabulin, albendazole, taltobulin, docetaxel",0.251037138743839,0.087246696328677,FALSE
+"H2009","Pearson.est","tyrosine kinase inhibitor",-0.47683,-1.13,0.313,1238,0.656,"UNC2250, vandetanib, BMS.599626, regorafenib, sorafenib, NVP.TAE226, tyrphostin.A9, tivantinib",0.504455662453552,0.18309616062434,FALSE
+"H2009","Pearson.est","VEGFR inhibitor",-0.39517,-0.938,0.543,993,0.788,"KI.8751, MK.2461, AEE788, RAF265, pazopanib, golvatinib, vandetanib, lucitanib, XL.647, OSI.930, foretinib, regorafenib, sorafenib, ENMD.2076",0.265200170411153,0.103473782510445,FALSE
+"H2009","Pearson.est","vitamin D receptor agonist",-0.5892,-1.38,0.101,884,0.503,"paricalcitol, doxercalciferol, alfacalcidol, ercalcitriol, maxacalcitol, tacalcitol",0.995678626217357,0.298432014944073,FALSE
+"HCC4006","Pearson.est","EGFR inhibitor",-0.74345,-1.74,0.0123,1237,0.121,"AEE788, pelitinib, BMS.599626, rociletinib, PD.168393, BMS.690514, icotinib, WZ.4002, PD.153035, CP.724714, neratinib, WZ8040, GW.583340, CNX.2006, dacomitinib, TAK.285, tucatinib, AZD8931, lapatinib, gefitinib, erlotinib, canertinib, poziotinib, CUDC.101, ARRY.334543, afatinib, AST.1306, XL.647, osimertinib",1.9100948885606,0.91721462968355,TRUE
+"HCC4006","Pearson.est","Abl kinase inhibitor",-0.62212,-1.49,0.0621,1146,0.451,"metatinib, imatinib, bosutinib, KW.2449, tozasertib, ZM.306416",1.20690839982342,0.345823458122039,FALSE
+"HCC4006","Pearson.est","acetylcholine receptor agonist",-0.56819,-1.36,0.119,1280,0.51,"xanomeline, pilocarpine",0.924453038607469,0.292429823902064,FALSE
+"HCC4006","Pearson.est","acetylcholine receptor antagonist",0.55555,1.65,0.0305,341,0.248,"methscopolamine, diphemanil, dicycloverine, hyoscyamine",1.51570016065321,0.605548319173784,TRUE
+"HCC4006","Pearson.est","adenosine receptor antagonist",-0.44388,-1.04,0.431,1445,0.646,"CGS.15943",0.365522729839268,0.189767482004916,FALSE
+"HCC4006","Pearson.est","adrenergic receptor agonist",0.25188,0.774,0.756,817,0.873,"oxymetazoline, xylazine, epinephrine, isoetharine, terbutaline, norepinephrine, clenbuterol, ritodrine, metaraminol, A61603, lidamidine, buphenine, methyldopa, isoxsuprine",0.121478204498793,0.0589857562944303,FALSE
+"HCC4006","Pearson.est","adrenergic receptor antagonist",0.17671,0.52,0.987,37,0.977,"imiloxan, atenolol....",0.00568284733036327,0.0101054362812269,FALSE
+"HCC4006","Pearson.est","AKT inhibitor",-0.77152,-1.85,0.00592,1223,0.0796,"GSK2110183, CCT128930, MK.2206, AZD5363, GDC.0068, A.674563, triciribine, uprosertib",2.22767829327708,1.09908693226233,TRUE
+"HCC4006","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.52524,-1.25,0.206,1038,0.552,"AP26113, CEP.37440, brigatinib, DMH1, alectinib, AZD3463",0.686132779630847,0.258060922270801,FALSE
+"HCC4006","Pearson.est","androgen receptor antagonist",0.8142,2.37,0,250,0.0131,"nilutamide, enzalutamide, flutamide, bicalutamide, cyproterone.acetate",Inf,1.88272870434424,TRUE
+"HCC4006","Pearson.est","antioxidant",-0.31729,-0.752,0.804,489,0.887,"trolox, taurine, mesna, chlorogenic.acid, rutin",0.0947439512515487,0.0520763801682736,FALSE
+"HCC4006","Pearson.est","AP inhibitor",-0.44261,-1.06,0.402,1135,0.642,"tanshinone.i, embelin",0.39577394691553,0.192464971931147,FALSE
+"HCC4006","Pearson.est","ATPase inhibitor",0.27771,0.767,0.702,175,0.846,"k.strophanthidin, digitoxigenin, ouabain, digitoxin",0.153662887870195,0.0726296369609765,FALSE
+"HCC4006","Pearson.est","Aurora kinase inhibitor",-0.78223,-1.86,0.00116,1119,0.14,"SNS.314, MK.5108, PF.03814735, CYC116, CCT129202, aurora.a.inhibitor.i, ENMD.2076, alisertib, KW.2449, tozasertib, AMG900, CCT137690, MK.8745, TAK.901, barasertib, PHA.680632, danusertib, AT.9283, barasertib.HQPA, GSK1070916, hesperadin, ZM.447439",2.93554201077308,0.853871964321762,TRUE
+"HCC4006","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44049,-1.05,0.416,862,0.644,"tedizolid, tilmicosin, azalomycin.b, valnemulin, radezolid",0.380906669373257,0.191114132640188,FALSE
+"HCC4006","Pearson.est","bacterial DNA gyrase inhibitor",0.69256,2.03,0.0112,327,0.073,"sarafloxacin, sparfloxacin, novobiocin, lomefloxacin, nadifloxacin",1.95078197732982,1.13667713987954,TRUE
+"HCC4006","Pearson.est","BCL inhibitor",0.27775,0.817,0.65,220,0.881,"HA14.1, navitoclax, oridonin",0.187086643357144,0.0550240915879521,FALSE
+"HCC4006","Pearson.est","Bcr.Abl kinase inhibitor",-0.55632,-1.32,0.142,1001,0.504,"bafetinib, metatinib, imatinib, bosutinib, tozasertib",0.847711655616944,0.297569463554475,FALSE
+"HCC4006","Pearson.est","benzodiazepine receptor agonist",0.24298,0.694,0.828,286,0.915,"gamma.aminobutyric.acid, eprinomectin, CL.218872, temazepam, CGS.20625, indiplon, bentazepam",0.0819696632151199,0.0385789059335517,FALSE
+"HCC4006","Pearson.est","bromodomain inhibitor",-0.61661,-1.44,0.0612,1139,0.429,"I.BET.762, I.BET151, OTX015, JQ1....",1.21324857785444,0.367542707815276,FALSE
+"HCC4006","Pearson.est","calcium channel blocker",-0.53905,-1.25,0.199,896,0.552,"fendiline, cinnarazine, SR.33805, tetrandrine, mibefradil, carboxyamidotriazole, penfluridol",0.701146923590293,0.258060922270801,FALSE
+"HCC4006","Pearson.est","CC chemokine receptor antagonist",-0.40456,-0.977,0.494,929,0.735,"SB.225002, navarixin, ZK811752, MK.0812",0.306273051076353,0.133712660915805,FALSE
+"HCC4006","Pearson.est","CDK inhibitor",-0.66952,-1.6,0.0232,1224,0.25,"ribociclib, BMS.265246, JNJ.7706621, abemaciclib, palbociclib, P276.00, aminopurvalanol.a, indisulam, R547, BMS.387032, alvocidib, PHA.793887, dinaciclib, AT.7519",1.6345120151091,0.602059991327962,FALSE
+"HCC4006","Pearson.est","CHK inhibitor",-0.53574,-1.27,0.204,772,0.561,"LY2606368, SCH.900776, CHIR.124, PF.477736, SB.218078, AZD7762, LY2603618",0.690369832574101,0.251037138743839,FALSE
+"HCC4006","Pearson.est","cyclooxygenase inhibitor",0.29372,0.88,0.566,103,0.842,"sulfasalazine, AM.404, tepoxalin, naproxen, piroxicam, phenylbutazone",0.247183568811729,0.0746879085003505,FALSE
+"HCC4006","Pearson.est","cytochrome P450 inhibitor",0.5521,1.59,0.0809,282,0.256,"morin, itraconazole, eplerenone, metyrapone, clotrimazole",1.09205147838773,0.59176003468815,FALSE
+"HCC4006","Pearson.est","DNA alkylating agent",-0.3959,-0.959,0.517,959,0.734,"cyclophosphamide, estramustine, satraplatin, TH.302, mitomycin.c",0.286509456906058,0.134303940083929,FALSE
+"HCC4006","Pearson.est","DNA inhibitor",-0.34161,-0.81,0.742,1149,0.9,"valrubicin, teroxirone, primaquine, oxaliplatin",0.129596094720973,0.0457574905606751,FALSE
+"HCC4006","Pearson.est","DNA methyltransferase inhibitor",-0.74579,-1.76,0.00364,1404,0.131,"azacitidine, fdcyd, decitabine",2.43889861635094,0.882728704344236,TRUE
+"HCC4006","Pearson.est","DNA polymerase inhibitor",-0.49189,-1.17,0.26,1084,0.526,"trifluridine, adefovir.dipivoxil, cephalomannine, cidofovir, idoxuridine",0.585026652029182,0.279014255846261,FALSE
+"HCC4006","Pearson.est","DNA synthesis inhibitor",-0.42974,-1.03,0.431,1008,0.648,"floxuridine, azodicarbonamide, anisomycin, enocitabine, cyclocytidine, mitomycin.c",0.365522729839268,0.188424994129407,FALSE
+"HCC4006","Pearson.est","dopamine receptor antagonist",-0.25114,-0.598,0.94,833,0.931,"lurasidone, ziprasidone, piperacetazine, mesoridazine, thioproperazine, sertindole, acetophenazine",0.0268721464003014,0.0310503190186574,FALSE
+"HCC4006","Pearson.est","estrogen receptor agonist",0.53264,1.56,0.0933,681,0.219,"estradiol, ethinyl.estradiol, erteberel, estradiol.cypionate, levonorgestrel, PPT, estrone, equol",1.0301183562535,0.659555885159882,FALSE
+"HCC4006","Pearson.est","estrogen receptor antagonist",-0.54336,-1.29,0.167,1360,0.544,"clomifene",0.777283528852417,0.26440110030182,FALSE
+"HCC4006","Pearson.est","FGFR inhibitor",-0.30098,-0.723,0.832,715,0.888,"lenvatinib, nintedanib, AZD4547, PD.173074, regorafenib, lucitanib",0.0798766737092761,0.051587034221399,FALSE
+"HCC4006","Pearson.est","FLT3 inhibitor",-0.4707,-1.11,0.331,1253,0.578,"ENMD.2076, pacritinib, KW.2449, sorafenib, tozasertib",0.480172006224281,0.238072161579471,FALSE
+"HCC4006","Pearson.est","glucocorticoid receptor agonist",-0.29674,-0.71,0.839,664,0.869,"triamcinolone, betamethasone, dexamethasone.acetate, desonide, fludroxycortide, ciclesonide, triamcinolone.acetonide, halcinonide, fluorometholone, clobetasol.propionate, prednisolone.hemisuccinate, difluprednate, fluticasone.propionate, halobetasol.propionate, deflazacort, flumethasone, flumethasone.pivalate, methylprednisolone",0.0762380391712997,0.0609802235513335,FALSE
+"HCC4006","Pearson.est","glutamate receptor antagonist",0.34946,1.03,0.4,96,0.716,"JNJ.16259685, latrepirdine, kynurenic.acid, diazooxonorleucine",0.397940008672038,0.145086977692144,FALSE
+"HCC4006","Pearson.est","glycogen synthase kinase inhibitor",0.3222,0.947,0.547,170,0.79,"tideglusib, CHIR.99021, CHIR.98014",0.262012673666569,0.102372908709559,FALSE
+"HCC4006","Pearson.est","growth factor receptor inhibitor",-0.55933,-1.33,0.146,806,0.55,"lestaurtinib, GSK1904529A, GW.441756, PHA.848125, GSK1838705A, danusertib, AZD3463",0.835647144215563,0.259637310505756,FALSE
+"HCC4006","Pearson.est","HCV inhibitor",-0.46547,-1.11,0.325,785,0.578,"mericitabine, PSI.7976, embelin, narlaprevir",0.488116639021126,0.238072161579471,FALSE
+"HCC4006","Pearson.est","HDAC inhibitor",-0.57726,-1.37,0.124,1151,0.525,"entinostat, R306465, ACY.1215, resminostat, M.344, SB.939, trichostatin.a, dacinostat, scriptaid, vorinostat, chidamide, AR.42, PCI.24781, givinostat",0.906578314837765,0.279840696594043,FALSE
+"HCC4006","Pearson.est","histamine receptor antagonist",-0.33424,-0.806,0.728,1068,0.887,"pheniramine, terfenadine, ebastine, tiotidine, levocetirizine",0.137868620686963,0.0520763801682736,FALSE
+"HCC4006","Pearson.est","HMGCR inhibitor",0.85407,2.48,0,56,0.00749,"pitavastatin, fluvastatin, mevastatin, atorvastatin",Inf,2.12551818230053,TRUE
+"HCC4006","Pearson.est","HSP inhibitor",-0.47821,-1.16,0.267,817,0.528,"SNX.5422, BIIB021, SNX.2112, ganetespib, VER.49009, NVP.AUY922, XL888, PU.H71, alvespimycin, tanespimycin",0.573488738635425,0.277366077466188,FALSE
+"HCC4006","Pearson.est","JAK inhibitor",-0.4891,-1.17,0.28,1142,0.526,"ruxolitinib, WHI.P154, AZ960, pacritinib, tozasertib, PRT062070, AT.9283",0.552841968657781,0.279014255846261,FALSE
+"HCC4006","Pearson.est","KIT inhibitor",-0.36104,-0.861,0.658,1039,0.855,"KI.8751, vatalanib, regorafenib, imatinib, sorafenib, OSI.930",0.181774106386044,0.0680338852718274,FALSE
+"HCC4006","Pearson.est","MDM inhibitor",0.49902,1.51,0.0651,104,0.211,"idasanutlin, AMG.232, nutlin.3",1.18641901143181,0.675717544702307,FALSE
+"HCC4006","Pearson.est","MEK inhibitor",-0.37452,-0.899,0.607,736,0.806,"U.0126, refametinib, AS.703026, selumetinib, MEK162, Ro.4987655, arctigenin, PD.0325901, TAK.733, cobimetinib, PD.184352, AZD8330, trametinib, nobiletin",0.216811308924742,0.0936649581949093,FALSE
+"HCC4006","Pearson.est","MET inhibitor",0.51321,1.56,0.0506,79,0.219,"PF.04217903, PHA.665752",1.2958494831602,0.659555885159882,FALSE
+"HCC4006","Pearson.est","microtubule inhibitor",-0.50496,-1.22,0.212,893,0.568,"colchicine, cytochalasin.b, vinflunine, podophyllotoxin, cabazitaxel, D.64131",0.673664139071249,0.245651664288981,FALSE
+"HCC4006","Pearson.est","mTOR inhibitor",-0.49359,-1.18,0.26,879,0.544,"temsirolimus, OSI.027, LY303511, WYE.354, WYE.125132, SB.2343, deforolimus, NVP.BEZ235, XL388, LY3023414, PF.04691502, PKI.179, everolimus, GDC.0980, AZD8055, MLN0128, AZD2014, torin.2, PF.05212384, GSK2126458",0.585026652029182,0.26440110030182,FALSE
+"HCC4006","Pearson.est","NFkB pathway inhibitor",-0.309,-0.733,0.816,889,0.892,"curcumin, Ro.106.9920, IKK.2.inhibitor.V, bortezomib, EVP4593, betulinic.acid",0.0883098412461389,0.0496351456238769,FALSE
+"HCC4006","Pearson.est","opioid receptor agonist",0.39875,1.16,0.253,873,0.57,"BW.180C, cebranopadol, spiradoline, ADL5859, trimebutine, salvinorin.a",0.596879478824182,0.244125144327509,FALSE
+"HCC4006","Pearson.est","p38 MAPK inhibitor",-0.39369,-0.963,0.526,925,0.744,"SB.242235, VX.702, SB.239063, talmapimod",0.279014255846261,0.128427064454121,FALSE
+"HCC4006","Pearson.est","PARP inhibitor",-0.32834,-0.789,0.756,721,0.874,"AG.14361, E7449, talazoparib, niraparib",0.121478204498793,0.058488567365597,FALSE
+"HCC4006","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.32531,-0.773,0.756,940,0.878,"sunitinib, SU014813, KI.8751, trapidil, crenolanib, vatalanib, regorafenib, imatinib, sorafenib",0.121478204498793,0.0565054840938974,FALSE
+"HCC4006","Pearson.est","phosphatase inhibitor",0.30622,0.913,0.548,28,0.814,"bis.maltolato.oxovanadium.IV., BVT.948",0.261219441515631,0.0893755951107988,FALSE
+"HCC4006","Pearson.est","phosphodiesterase inhibitor",0.53794,1.54,0.105,124,0.211,"anagrelide, GSK256066, enoximone, avanafil",0.978810700930062,0.675717544702307,FALSE
+"HCC4006","Pearson.est","PI3K inhibitor",-0.55516,-1.32,0.147,1019,0.504,"SB.2343, YM.201636, NVP.BEZ235, LY3023414, PF.04691502, PI3K.IN.2, CUDC.907, PKI.179, BGT226, buparlisib, CH5132799, GDC.0980, PF.05212384, TG.100713, PIK.75, GSK2126458, alpelisib, taselisib",0.832682665251824,0.297569463554475,FALSE
+"HCC4006","Pearson.est","PLK inhibitor",-0.61724,-1.48,0.0568,1236,0.42,"volasertib, GW.843682X, BI.2536, NMS.1286937",1.24565166428898,0.3767507096021,FALSE
+"HCC4006","Pearson.est","potassium channel blocker",0.26768,0.799,0.706,1062,0.871,"dofetilide, meglitinide, mepivacaine, ibutilide, oleoylethanolamide, ML133",0.151195298948196,0.0599818449923368,FALSE
+"HCC4006","Pearson.est","PPAR receptor agonist",0.55448,1.66,0.0122,649,0.293,"clofibrate, GW.501516, fenofibrate, pterostilbene, oleoylethanolamide, S26948, ciprofibrate",1.91364016932525,0.533132379645891,FALSE
+"HCC4006","Pearson.est","progesterone receptor agonist",0.51179,1.49,0.0694,108,0.203,"norethindrone.acetate, norethindrone, norgestrel",1.15864052954514,0.692503962086787,FALSE
+"HCC4006","Pearson.est","proteasome inhibitor",0.24722,0.692,0.804,1092,0.881,"MG.132, oprozomib, ixazomib.citrate, ixazomib, ONX.0914, delanzomib, carfilzomib, bortezomib",0.0947439512515487,0.0550240915879521,FALSE
+"HCC4006","Pearson.est","protein synthesis inhibitor",-0.506,-1.22,0.21,1168,0.568,"azomycin..2.nitroimidazole., puromycin, homoharringtonine, anguidine, bruceantin, tedizolid.phosphate, thiostrepton",0.677780705266081,0.245651664288981,FALSE
+"HCC4006","Pearson.est","protein tyrosine kinase inhibitor",-0.72377,-1.72,0.0073,1174,0.115,"tyrphostin.A9, mubritinib, AV.412, BMS.599626, CP.724714, NVP.TAE226",2.13667713987954,0.939302159646388,TRUE
+"HCC4006","Pearson.est","RAF inhibitor",-0.30709,-0.721,0.855,978,0.873,"RAF265, AZ.628, regorafenib, CEP.32496, TAK.632, sorafenib",0.0680338852718274,0.0589857562944303,FALSE
+"HCC4006","Pearson.est","RET tyrosine kinase inhibitor",-0.58893,-1.4,0.0865,940,0.489,"sunitinib, cabozantinib, vandetanib, regorafenib, sorafenib",1.06298389253519,0.31069114087638,FALSE
+"HCC4006","Pearson.est","retinoid receptor agonist",-0.33284,-0.789,0.757,891,0.874,"fenretinide, tamibarotene, bexarotene, AM.580, CD.437",0.120904120499927,0.058488567365597,FALSE
+"HCC4006","Pearson.est","ribonucleotide reductase inhibitor",0.28164,0.823,0.624,1043,0.915,"pentostatin, hydroxyurea, fludarabine, triapine, cladribine, cytarabine, LY2334737, clofarabine, fludarabine.phosphate, gemcitabine",0.204815410317576,0.0385789059335517,FALSE
+"HCC4006","Pearson.est","serotonin receptor agonist",0.33789,0.985,0.438,14,0.761,"NAN.190",0.3585258894959,0.118615343229427,FALSE
+"HCC4006","Pearson.est","serotonin receptor antagonist",-0.35534,-0.838,0.697,765,0.875,"SB.228357, lurasidone, ziprasidone, aripiprazole, SB.216641, RS.16566, sertindole",0.156767221901991,0.0579919469776868,FALSE
+"HCC4006","Pearson.est","sodium channel blocker",-0.26301,-0.62,0.917,1023,0.932,"lappaconite, ajmaline, benzethonium, brivaracetam",0.0376306643299789,0.0305840876460186,FALSE
+"HCC4006","Pearson.est","src inhibitor",-0.47056,-1.12,0.32,1264,0.594,"bosutinib, ZM.306416",0.494850021680094,0.226213555018806,FALSE
+"HCC4006","Pearson.est","sterol demethylase inhibitor",0.36755,1.07,0.336,918,0.687,"posaconazole, lanoconazole, chlormidazole, terconazole, ketoconazole, sulconazole",0.473660722610156,0.16304326294045,FALSE
+"HCC4006","Pearson.est","TGF beta receptor inhibitor",-0.40083,-0.951,0.565,578,0.731,"LY2109761, D.4476, SB.431542, adaprev, repsox, SB.525334",0.247951552180562,0.13608262304214,FALSE
+"HCC4006","Pearson.est","thymidylate synthase inhibitor",-0.60835,-1.45,0.0778,1045,0.451,"doxifluridine, trifluridine, carmofur, raltitrexed",1.10902040301031,0.345823458122039,FALSE
+"HCC4006","Pearson.est","topoisomerase inhibitor",-0.46263,-1.08,0.377,795,0.62,"amsacrine, idarubicin, doxorubicin, beta.lapachone, teniposide, irinotecan, epirubicin, voreloxin, daunorubicin, valrubicin, etoposide, licochalcone.a, camptothecin, genz.644282, amonafide, TAS.103, SN.38, exatecan.mesylate",0.423658649794207,0.207608310501746,FALSE
+"HCC4006","Pearson.est","tubulin polymerization inhibitor",-0.50092,-1.2,0.243,992,0.543,"vinorelbine, vincristine, ABT.751, dolastatin.10, mebendazole, podophyllotoxin, flubendazole, parbendazole, indibulin, paclitaxel, plinabulin, oxibendazole, epothilone.b, nocodazole, fosbretabulin, docetaxel, albendazole",0.614393726401688,0.265200170411153,FALSE
+"HCC4006","Pearson.est","tyrosine kinase inhibitor",-0.51397,-1.21,0.221,912,0.566,"tyrphostin.AG.99, sunitinib, cabozantinib, vandetanib, bafetinib, tivantinib, tyrphostin.A9, regorafenib, mubritinib, AV.412, UNC2250, sorafenib, BMS.599626, aminopurvalanol.a, CP.724714, NVP.TAE226",0.655607726314889,0.247183568811729,FALSE
+"HCC4006","Pearson.est","VEGFR inhibitor",-0.49355,-1.2,0.223,940,0.543,"sunitinib, PD.173074, cabozantinib, RAF265, vandetanib, SU014813, KI.8751, vatalanib, foretinib, regorafenib, AEE788, ENMD.2076, sorafenib, OSI.930, golvatinib, BMS.690514, lucitanib, ZM.306416, XL.647",0.651695136951839,0.265200170411153,FALSE
+"HCC4006","Pearson.est","vitamin D receptor agonist",-0.49591,-1.18,0.25,848,0.544,"paricalcitol, alfacalcidol, ercalcitriol, maxacalcitol, tacalcitol",0.602059991327962,0.26440110030182,FALSE
+"HCC2279","Pearson.est","EGFR inhibitor",0.22816,0.527,0.963,723,1,"CUDC.101, tucatinib, dovitinib, TAK.285, AST.1306, GW.583340, WZ.3146, salvianolic.acid.B, rociletinib, tyrphostin.AG.1478, ARRY.334543, AEE788, BIBX.1382, CP.724714, afatinib, CNX.2006, BIBU.1361, lapatinib, WZ.4002, neratinib, OSI.420, osimertinib",0.0163737128754655,0,FALSE
+"HCC2279","Pearson.est","Abl kinase inhibitor",0.3736,0.851,0.677,337,0.83,"tozasertib, imatinib, bafetinib, KW.2449",0.169411331314856,0.0809219076239261,FALSE
+"HCC2279","Pearson.est","acetylcholine receptor agonist",0.36498,0.845,0.703,389,0.823,"xanomeline, oxiracetam",0.153044674980176,0.0846001647877302,FALSE
+"HCC2279","Pearson.est","acetylcholine receptor antagonist",-0.42322,-1.18,0.217,1080,0.391,"hyoscyamine, methscopolamine, dicycloverine, iododexetimide",0.66354026615147,0.407823242604133,FALSE
+"HCC2279","Pearson.est","adenosine receptor antagonist",0.39903,0.916,0.587,873,0.757,"CGS.15943, MRS.1220, SCH.58261, PSB.1115, sulmazole, theophylline, istradefylline",0.231361898752386,0.120904120499927,FALSE
+"HCC2279","Pearson.est","adrenergic receptor agonist",-0.56204,-1.63,0.0526,1199,0.213,"methyldopa, ritodrine, isoetharine, isoxsuprine, epinephrine, terbutaline, oxymetazoline, xylazine",1.27901425584626,0.671620396561262,FALSE
+"HCC2279","Pearson.est","adrenergic receptor antagonist",0.29627,0.688,0.868,676,0.999,"atipamezole, practolol, atenolol......, dihydroergocristine, oxprenolol, carvedilol, dronedarone, vincamine, idazoxan, propranolol, RS.17053",0.0614802748235081,0.000434511774017692,FALSE
+"HCC2279","Pearson.est","AKT inhibitor",0.67717,1.55,0.0301,370,0.222,"uprosertib, GDC.0068, A.674563, GSK2110183, triciribine, MK.2206, ONC201, AZD5363",1.52143350440616,0.653647025549361,TRUE
+"HCC2279","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.23651,0.557,0.96,517,1,"AZD3463, DMH1, NVP.TAE684, alectinib, crizotinib",0.0177287669604316,0,FALSE
+"HCC2279","Pearson.est","androgen receptor antagonist",-0.78583,-2.3,0,1201,0.0261,"enzalutamide, nilutamide, cyproterone.acetate, flutamide, bicalutamide",Inf,1.58335949266172,TRUE
+"HCC2279","Pearson.est","antioxidant",-0.73857,-2.06,0.0162,1147,0.0515,"benfotiamine, taurine, rutin, mesna",1.79048498545737,1.28819277095881,TRUE
+"HCC2279","Pearson.est","AP inhibitor",-0.48255,-1.32,0.156,1373,0.307,"birinapant, GDC.0152",0.806875401645538,0.512861624522813,FALSE
+"HCC2279","Pearson.est","ATPase inhibitor",0.55578,1.27,0.182,129,0.433,"oligomycin.a, evodiamine, digoxin, NMS.873",0.739928612014925,0.363512103646635,FALSE
+"HCC2279","Pearson.est","Aurora kinase inhibitor",0.76469,1.78,0.00249,240,0.126,"CCT137690, barasertib.HQPA, PHA.680632, AT.9283, barasertib, SNS.314, hesperadin, danusertib, AMG900, ZM.447439, alisertib, MK.8745, TAK.901, tozasertib, aurora.a.inhibitor.i, ENMD.2076, GSK1070916, PF.03814735",2.60380065290426,0.899629454882437,TRUE
+"HCC2279","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.4393,1.01,0.483,215,0.784,"valnemulin, azalomycin.b",0.316052869248488,0.105683937315562,FALSE
+"HCC2279","Pearson.est","bacterial DNA gyrase inhibitor",-0.32014,-0.886,0.556,461,0.649,"nadifloxacin, norfloxacin, novobiocin, lomefloxacin, trovafloxacin, sparfloxacin, finafloxacin, sarafloxacin",0.254925208417942,0.187755303199631,FALSE
+"HCC2279","Pearson.est","BCL inhibitor",0.56715,1.3,0.151,236,0.409,"TW.37, gossypol, obatoclax",0.821023052706831,0.388276691992658,FALSE
+"HCC2279","Pearson.est","Bcr.Abl kinase inhibitor",-0.38612,-1.12,0.309,1447,0.44,"dasatinib",0.510041520575165,0.356547323513813,FALSE
+"HCC2279","Pearson.est","benzodiazepine receptor agonist",-0.31433,-0.863,0.59,1311,0.656,"temazepam, gamma.aminobutyric.acid, eprinomectin, CGS.20625",0.229147988357856,0.18309616062434,FALSE
+"HCC2279","Pearson.est","bromodomain inhibitor",0.96117,2.22,0,62,0,"OTX015, JQ1...., I.BET151, I.BET.762, PFI.1, bromosporine",Inf,Inf,TRUE
+"HCC2279","Pearson.est","calcium channel blocker",0.7162,1.64,0.0134,178,0.161,"carboxyamidotriazole, mibefradil, SR.33805, tetrandrine, penfluridol",1.87289520163519,0.79317412396815,TRUE
+"HCC2279","Pearson.est","CC chemokine receptor antagonist",0.51143,1.17,0.281,230,0.51,"SB.225002, ZK811752",0.55129368009492,0.292429823902064,FALSE
+"HCC2279","Pearson.est","CDK inhibitor",0.66741,1.55,0.0319,227,0.222,"indisulam, BMS.387032, TG.02, dinaciclib, R547, P276.00, AT.7519, palbociclib, abemaciclib, JNJ.7706621, PHA.793887, arcyriaflavin.a, ribociclib",1.49620931694282,0.653647025549361,TRUE
+"HCC2279","Pearson.est","CHK inhibitor",0.19251,0.442,0.996,239,1,"SB.218078",0.00174066157630127,0,FALSE
+"HCC2279","Pearson.est","cyclooxygenase inhibitor",0.18898,0.437,0.992,598,0.993,"curcumin, tepoxalin, piroxicam, FR.122047, ketoprofen, tryptanthrin, ramifenazone",0.00348832784582135,0.00305075150461883,FALSE
+"HCC2279","Pearson.est","cytochrome P450 inhibitor",-0.76497,-2.26,0,1280,0.0174,"metyrapone, morin, eplerenone, clotrimazole, itraconazole",Inf,1.7594507517174,TRUE
+"HCC2279","Pearson.est","DNA alkylating agent",0.53353,1.23,0.217,293,0.459,"mitomycin.c, TH.302, satraplatin, estramustine, melphalan, cyclophosphamide",0.66354026615147,0.338187314462739,FALSE
+"HCC2279","Pearson.est","DNA inhibitor",0.48074,1.11,0.334,278,0.618,"oxaliplatin, chlorambucil, valrubicin, pibenzimol, primaquine, teroxirone, melphalan",0.476253533188435,0.209011524911184,FALSE
+"HCC2279","Pearson.est","DNA methyltransferase inhibitor",0.65327,1.49,0.0532,406,0.249,"fdcyd, azacitidine, disulfiram, SGI.1027, decitabine",1.27408836770495,0.603800652904264,FALSE
+"HCC2279","Pearson.est","DNA polymerase inhibitor",0.42745,0.971,0.527,269,0.743,"trifluridine, idoxuridine, cephalomannine",0.278189384787453,0.129011186239425,FALSE
+"HCC2279","Pearson.est","DNA synthesis inhibitor",0.4049,0.933,0.554,348,0.744,"mitomycin.c, cyclocytidine, anisomycin, enocitabine, floxuridine",0.25649023527157,0.128427064454121,FALSE
+"HCC2279","Pearson.est","dopamine receptor antagonist",0.20648,0.475,0.994,65,1,"sertindole",0.00261361560268669,0,FALSE
+"HCC2279","Pearson.est","estrogen receptor agonist",-0.60855,-1.76,0.0326,1425,0.156,"estradiol.cypionate",1.48678239993206,0.806875401645538,TRUE
+"HCC2279","Pearson.est","estrogen receptor antagonist",0.22205,0.512,0.977,681,1,"clomifene, toremifene, fulvestrant",0.0101054362812269,0,FALSE
+"HCC2279","Pearson.est","FGFR inhibitor",0.55021,1.25,0.177,497,0.454,"regorafenib, lucitanib, dovitinib, erdafitinib, lenvatinib, PD.173074",0.752026733638193,0.342944147142896,FALSE
+"HCC2279","Pearson.est","FLT3 inhibitor",0.62166,1.46,0.069,412,0.242,"sorafenib, pacritinib, TG.02, tozasertib, quizartinib, TG.101348, ENMD.2076, dovitinib, KW.2449, lestaurtinib, sunitinib",1.16115090926274,0.616184634019569,FALSE
+"HCC2279","Pearson.est","glucocorticoid receptor agonist",-0.17147,-0.496,0.995,244,0.987,"deflazacort, rimexolone, methylprednisolone, betamethasone, difluprednate, halobetasol.propionate, prednisolone.hemisuccinate, ciclesonide, flumethasone, prednisolone, fludroxycortide, flumethasone.pivalate, fluticasone.propionate, halcinonide, clobetasol.propionate, fluorometholone, beclomethasone.dipropionate, triamcinolone, desonide, triamcinolone.acetonide, hydrocortisone, prednisolone.acetate, dexamethasone.acetate, piretanide, fluocinolone.acetonide",0.00217691925427455,0.00568284733036327,FALSE
+"HCC2279","Pearson.est","glutamate receptor antagonist",-0.55341,-1.6,0.0833,1165,0.205,"CGP.37849, tiletamine, MTPG, kynurenic.acid, diazooxonorleucine, JNJ.16259685, SIB.1757, latrepirdine",1.07935499859321,0.688246138944246,FALSE
+"HCC2279","Pearson.est","glycogen synthase kinase inhibitor",-0.3433,-0.955,0.494,1204,0.595,"TWS.119, tideglusib, CHIR.98014",0.306273051076353,0.22548303427145,FALSE
+"HCC2279","Pearson.est","growth factor receptor inhibitor",0.62593,1.45,0.0783,368,0.242,"danusertib, AZD3463, GSK1838705A, lestaurtinib",1.10623823794206,0.616184634019569,FALSE
+"HCC2279","Pearson.est","HCV inhibitor",0.41052,0.944,0.552,597,0.741,"mericitabine, Ro.9187, narlaprevir, embelin",0.258060922270801,0.130181792020672,FALSE
+"HCC2279","Pearson.est","HDAC inhibitor",0.6752,1.54,0.0325,189,0.196,"M.344, R306465, givinostat, resminostat, SB.939, scriptaid, PCI.24781, RGFP966, chidamide, dacinostat, AR.42, entinostat, trichostatin.a, vorinostat, belinostat",1.48811663902113,0.707743928643524,TRUE
+"HCC2279","Pearson.est","histamine receptor antagonist",-0.27692,-0.823,0.706,396,0.694,"cyproheptadine, levocetirizine, tiotidine, astemizole, ebastine, pheniramine, epinastine, chloropyramine, terfenadine, ICI.162846, famotidine, ranitidine, BF2.649, lafutidine, tecastemizole, nizatidine, cimetidine, zolantidine",0.151195298948196,0.158640529545145,FALSE
+"HCC2279","Pearson.est","HMGCR inhibitor",-0.79404,-2.26,0.00549,1145,0.0174,"atorvastatin, mevastatin, simvastatin, lovastatin, pitavastatin, fluvastatin",2.26042765554991,1.7594507517174,TRUE
+"HCC2279","Pearson.est","HSP inhibitor",0.59258,1.36,0.113,565,0.368,"NMS.E973, tanespimycin, XL888, alvespimycin, BIIB021, NVP.AUY922, PU.H71, SNX.5422, ganetespib, SNX.2112, VER.49009",0.94692155651658,0.434152181326482,FALSE
+"HCC2279","Pearson.est","JAK inhibitor",0.60092,1.38,0.106,426,0.347,"pacritinib, AT.9283, TG.02, tozasertib, TG.101348, AZ960, TG.101209, PRT062070, lestaurtinib, LY2784544",0.97469413473523,0.459670525209126,FALSE
+"HCC2279","Pearson.est","KIT inhibitor",0.42677,0.972,0.531,472,0.76,"sorafenib, pazopanib, regorafenib, OSI.930, imatinib, vatalanib, sunitinib, lenvatinib, cediranib, motesanib",0.274905478918531,0.119186407719209,FALSE
+"HCC2279","Pearson.est","MDM inhibitor",0.45397,1.04,0.423,595,0.734,"serdemetan, nutlin.3, RITA",0.373659632624958,0.134303940083929,FALSE
+"HCC2279","Pearson.est","MEK inhibitor",-0.45252,-1.31,0.194,1067,0.272,"PD.0325901, cobimetinib, AZD8330, selumetinib, PD.184352, Ro.4987655, TAK.733, PD.318088, PD.198306, refametinib, MEK1.2.inhibitor",0.712198270069774,0.565431095965801,FALSE
+"HCC2279","Pearson.est","MET inhibitor",-0.47708,-1.38,0.156,1435,0.275,"PF.04217903",0.806875401645538,0.560667306169737,FALSE
+"HCC2279","Pearson.est","microtubule inhibitor",0.57984,1.33,0.131,340,0.371,"vinflunine, D.64131, podophyllotoxin, cabazitaxel, vinblastine",0.882728704344236,0.430626090384954,FALSE
+"HCC2279","Pearson.est","mTOR inhibitor",0.46034,1.05,0.413,573,0.731,"WYE.125132, torin.2, GSK2126458, PF.05212384, AZD2014, GDC.0980, PKI.179, XL388, AZD8055, PI.103, deforolimus, voxtalisib, MLN0128, everolimus, temsirolimus, WYE.354, PP242, ku.0063794",0.384049948343599,0.13608262304214,FALSE
+"HCC2279","Pearson.est","NFkB pathway inhibitor",0.52594,1.24,0.202,254,0.457,"EVP4593, curcumin, parthenolide...., Ro.106.9920, betulinic.acid",0.694648630553376,0.34008379993015,FALSE
+"HCC2279","Pearson.est","opioid receptor agonist",-0.52129,-1.46,0.106,1158,0.263,"spiradoline, ADL5859, BW.180C",0.97469413473523,0.580044251510242,FALSE
+"HCC2279","Pearson.est","p38 MAPK inhibitor",0.32344,0.756,0.793,690,0.935,"talmapimod, SB.239063, skepinone.l, CMPD.1, SB.242235",0.100726812682396,0.0291883891274822,FALSE
+"HCC2279","Pearson.est","PARP inhibitor",0.70994,1.65,0.0183,177,0.179,"niraparib, talazoparib, olaparib, PJ.34",1.73754891026957,0.747146969020107,TRUE
+"HCC2279","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.43126,0.987,0.486,472,0.75,"sorafenib, pazopanib, regorafenib, axitinib, imatinib, dovitinib, trapidil, vatalanib, crenolanib, sunitinib, lenvatinib, motesanib",0.313363730737707,0.1249387366083,FALSE
+"HCC2279","Pearson.est","phosphatase inhibitor",0.43126,0.995,0.491,391,0.753,"mycophenolate.mofetil, mycophenolic.acid, CID.5458317, GSK2830371",0.308918507877032,0.123205023799299,FALSE
+"HCC2279","Pearson.est","phosphodiesterase inhibitor",-0.33308,-0.967,0.436,1149,0.608,"YM.976, EMD.53998, enoximone, GSK256066, anagrelide",0.360513510731414,0.216096420727265,FALSE
+"HCC2279","Pearson.est","PI3K inhibitor",0.52239,1.21,0.232,444,0.448,"CUDC.907, taselisib, buparlisib, GSK2126458, PF.05212384, PI3K.IN.2, alpelisib, YM.201636, GDC.0980, BGT226, CH5132799, PIK.75, PKI.179, PI.103, voxtalisib",0.6345120151091,0.348721986001856,FALSE
+"HCC2279","Pearson.est","PLK inhibitor",0.75434,1.75,0.00864,361,0.116,"volasertib, GW.843682X, NMS.1286937, BI.2536, rigosertib, GSK461364, HMN.214",2.06348625752111,0.935542010773082,TRUE
+"HCC2279","Pearson.est","potassium channel blocker",-0.37897,-1.1,0.281,1184,0.438,"dofetilide, mepivacaine, meglitinide",0.55129368009492,0.3585258894959,FALSE
+"HCC2279","Pearson.est","PPAR receptor agonist",0.22876,0.528,0.96,244,1,"ciprofibrate",0.0177287669604316,0,FALSE
+"HCC2279","Pearson.est","progesterone receptor agonist",-0.53931,-1.56,0.0503,1156,0.208,"norgestrel, nomegestrol.acetate, danazol, norethindrone.acetate",1.29843201494407,0.681936665037238,FALSE
+"HCC2279","Pearson.est","proteasome inhibitor",0.43293,0.998,0.479,736,0.767,"MG.132, carfilzomib, bortezomib, oprozomib, ONX.0914, delanzomib",0.319664486585437,0.115204636051019,FALSE
+"HCC2279","Pearson.est","protein synthesis inhibitor",0.5547,1.28,0.167,33,0.432,"anguidine, homoharringtonine, bruceantin, harringtonine",0.777283528852417,0.364516253185088,FALSE
+"HCC2279","Pearson.est","protein tyrosine kinase inhibitor",0.57957,1.34,0.12,200,0.37,"NVP.TAE226, tyrphostin.A9, mubritinib",0.920818753952375,0.431798275933005,FALSE
+"HCC2279","Pearson.est","RAF inhibitor",0.57877,1.34,0.125,217,0.37,"sorafenib, regorafenib, TAK.632, RAF265, SB.590885",0.903089986991944,0.431798275933005,FALSE
+"HCC2279","Pearson.est","RET tyrosine kinase inhibitor",0.66804,1.54,0.0254,49,0.196,"sorafenib, regorafenib",1.59516628338006,0.707743928643524,TRUE
+"HCC2279","Pearson.est","retinoid receptor agonist",0.63515,1.46,0.0602,231,0.242,"adarotene, fenretinide, bexarotene",1.22040350874218,0.616184634019569,FALSE
+"HCC2279","Pearson.est","ribonucleotide reductase inhibitor",0.52707,1.22,0.216,548,0.461,"clofarabine, cladribine, LY2334737, gemcitabine, pentostatin, fludarabine.phosphate, fludarabine",0.665546248849069,0.336299074610352,FALSE
+"HCC2279","Pearson.est","serotonin receptor agonist",0.25867,0.599,0.933,661,1,"aripiprazole, pardoprunox, zolmitriptan",0.0301183562535,0,FALSE
+"HCC2279","Pearson.est","serotonin receptor antagonist",0.38468,0.871,0.668,609,0.815,"sertindole, lurasidone, aripiprazole, paliperidone, SB.228357, SB.200646, SB.216641",0.175223537524454,0.0888423912600234,FALSE
+"HCC2279","Pearson.est","sodium channel blocker",0.42276,0.969,0.539,386,0.729,"benzethonium, lappaconite, brivaracetam, triamterene, ajmaline",0.268411234813261,0.137272471682025,FALSE
+"HCC2279","Pearson.est","src inhibitor",-0.49623,-1.45,0.101,1401,0.247,"saracatinib, dasatinib",0.995678626217357,0.607303046740334,FALSE
+"HCC2279","Pearson.est","sterol demethylase inhibitor",-0.33954,-0.935,0.461,1243,0.596,"sulconazole, terconazole, lanoconazole",0.336299074610352,0.224753740259764,FALSE
+"HCC2279","Pearson.est","TGF beta receptor inhibitor",-0.46117,-1.31,0.175,665,0.272,"adaprev, D.4476, SB.431542, SB.525334, LY2109761, repsox",0.756961951313706,0.565431095965801,FALSE
+"HCC2279","Pearson.est","thymidylate synthase inhibitor",0.62897,1.46,0.0703,405,0.242,"raltitrexed, trifluridine, carmofur, doxifluridine",1.15304467498018,0.616184634019569,FALSE
+"HCC2279","Pearson.est","topoisomerase inhibitor",0.69351,1.6,0.025,311,0.196,"topotecan, epirubicin, etoposide.phosphate, idarubicin, doxorubicin, irinotecan, daunorubicin, valrubicin, exatecan.mesylate, genz.644282, TAS.103, amsacrine, beta.lapachone, SN.38, voreloxin, teniposide, rubitecan, nemorubicin, amonafide, etoposide",1.60205999132796,0.707743928643524,TRUE
+"HCC2279","Pearson.est","tubulin polymerization inhibitor",0.72947,1.69,0.0145,340,0.159,"albendazole, taltobulin, fosbretabulin, vindesine, vincristine, vinorelbine, combretastatin.A.4, parbendazole, KX2.391, docetaxel, nocodazole, verubulin, indibulin, paclitaxel, ABT.751, podophyllotoxin, CYT.997, mebendazole, dolastatin.10, fenbendazole, BNC105, flubendazole, plinabulin, vinblastine",1.83863199776503,0.798602875679548,TRUE
+"HCC2279","Pearson.est","tyrosine kinase inhibitor",0.41738,0.966,0.527,262,0.718,"sorafenib, regorafenib, tivantinib, NVP.TAE226, tyrphostin.A9, UNC2250, mubritinib, bafetinib",0.278189384787453,0.1438755557577,FALSE
+"HCC2279","Pearson.est","VEGFR inhibitor",0.52843,1.21,0.227,523,0.448,"sorafenib, pazopanib, regorafenib, golvatinib, OSI.930, RAF265, axitinib, ENMD.2076, lucitanib, foretinib, dovitinib, vatalanib, sunitinib, lenvatinib, TG.100572, cediranib, motesanib, tivozanib, PD.173074, cabozantinib, AEE788",0.643974142806877,0.348721986001856,FALSE
+"HCC2279","Pearson.est","vitamin D receptor agonist",0.43234,1,0.457,825,0.784,"maxacalcitol, tacalcitol, doxercalciferol, alfacalcidol, paricalcitol, ercalcitriol, calcitriol",0.34008379993015,0.105683937315562,FALSE
+"H520","Pearson.est","EGFR inhibitor",-0.4739,-1.11,0.327,969,0.639,"BMS.599626, pelitinib, PD.168393, rociletinib, BIBU.1361, tyrphostin.AG.1478, BIBX.1382, erlotinib, gefitinib, dacomitinib, canertinib, CUDC.101, osimertinib, AZD8931, CNX.2006, WZ.4002, WZ.3146, lapatinib, afatinib, ARRY.334543, neratinib, poziotinib, tucatinib, CP.724714, AST.1306",0.485452247339714,0.1944991418416,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",0.55468,1.51,0.0857,182,0.258,"dasatinib, ponatinib, metatinib, bafetinib",1.0670191780768,0.58838029403677,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",-0.44403,-1.06,0.388,1076,0.698,"pilocarpine, oxiracetam, xanomeline",0.411168274405793,0.156144577376839,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",0.40135,1.13,0.267,227,0.58,"dicycloverine, methscopolamine, iododexetimide",0.573488738635425,0.236572006437063,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",-0.51294,-1.21,0.236,1064,0.631,"SCH.58261, CGS.15943, MRS.1220",0.627087997029893,0.199970640755866,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.49324,1.42,0.107,98,0.325,"ritodrine, oxymetazoline, clenbuterol, terbutaline",0.97061622231479,0.488116639021126,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",-0.33073,-0.772,0.78,719,0.945,"oxprenolol, atipamezole, vincamine, dronedarone, imiloxan, propranolol, dihydroergocristine, naftidrofuryl, RS.17053, prazosin",0.10790539730952,0.0245681914907371,FALSE
+"H520","Pearson.est","AKT inhibitor",-0.5733,-1.35,0.131,991,0.497,"ONC201, GDC.0068, A.674563, AZD5363, AT7867, uprosertib, GSK2110183",0.882728704344236,0.303643611266668,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.34743,0.953,0.467,167,0.766,"GW.788388, CEP.37440, crizotinib, lorlatinib",0.330683119433888,0.115771230367396,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.54109,1.58,0.0821,216,0.335,"bicalutamide, cyproterone.acetate, RU.58841",1.08565684288056,0.474955192963155,FALSE
+"H520","Pearson.est","antioxidant",0.53883,1.52,0.0512,671,0.311,"taurine, chlorogenic.acid, benfotiamine, trolox, mesna, rutin",1.29073003902417,0.507239610973163,FALSE
+"H520","Pearson.est","AP inhibitor",-0.47909,-1.14,0.303,1417,0.648,"tanshinone.i",0.518557371497695,0.188424994129407,FALSE
+"H520","Pearson.est","ATPase inhibitor",-0.46542,-1.1,0.352,1126,0.637,"rabeprazole, evodiamine, NMS.873, oligomycin.a",0.453457336521869,0.19586056766465,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.66809,-1.59,0.0352,1212,0.267,"PF.03814735, CCT137690, AMG900, GSK1070916, alisertib, MK.8745, CYC116, TAK.901, ZM.447439, AT.9283, barasertib.HQPA, SNS.314, danusertib, PHA.680632",1.45345733652187,0.573488738635425,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.24789,-0.577,0.949,1198,0.981,"radezolid, josamycin",0.0227337875727074,0.0083309926200515,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.35553,1.01,0.376,52,0.692,"sparfloxacin, novobiocin",0.424812155072339,0.159893905543242,FALSE
+"H520","Pearson.est","BCL inhibitor",0.28472,0.823,0.677,1038,0.918,"HA14.1, navitoclax, oridonin, gossypol, ABT.737, TW.37, obatoclax, venetoclax",0.169411331314856,0.0371573187987575,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.70626,2.04,0.0243,182,0.152,"dasatinib, ponatinib, metatinib, bafetinib",1.61439372640169,0.818156412055227,TRUE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.1742,0.481,0.986,122,1,"temazepam, eprinomectin",0.0061230850587888,0,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.8086,-1.91,0.00127,1166,0.0676,"bromosporine, PFI.1, I.BET.762, JQ1...., I.BET151, OTX015",2.89619627904404,1.17005330405836,TRUE
+"H520","Pearson.est","calcium channel blocker",-0.43963,-1.04,0.391,687,0.717,"cinnarazine, SKF.96365, efonidipine.monoethanolate, SR.33805, tetrandrine, carboxyamidotriazole, mibefradil, fendiline",0.407823242604133,0.1444808443322,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",-0.39619,-0.949,0.521,1152,0.783,"ZK811752, SB.225002",0.283162276700476,0.106238237942057,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.53282,-1.25,0.193,899,0.6,"palbociclib, kenpaullone, dinaciclib, TG.02, CR8..R., indirubin, BMS.265246, ribociclib, JNJ.7706621, AT.7519, BMS.387032, indisulam, arcyriaflavin.a, R547, PHA.793887",0.714442690992226,0.221848749616356,FALSE
+"H520","Pearson.est","CHK inhibitor",0.55817,1.62,0.0718,231,0.354,"SCH.900776, LY2606368, LY2603618, AZD7762",1.1438755557577,0.450996737974212,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",-0.3222,-0.777,0.745,929,0.962,"curcumin, FK.3311, piroxicam, tryptanthrin, AM.404, FR.122047, aspirin, amfenac, naproxen",0.127843727251707,0.0168249279621871,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.59016,1.66,0.0605,295,0.375,"itraconazole, eplerenone, clotrimazole, metyrapone",1.21824462534753,0.425968732272281,FALSE
+"H520","Pearson.est","DNA alkylating agent",0.17691,0.474,0.99,228,0.99,"cisplatin, carmustine, estramustine, dacarbazine",0.00436480540245009,0.00436480540245009,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.29622,-0.702,0.849,927,0.95,"teroxirone, pibenzimol, valrubicin, bendamustine, mechlorethamine, busulfan, primaquine, oxaliplatin",0.0710923097560473,0.0222763947111523,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.47213,-1.11,0.363,960,0.639,"disulfiram, azacitidine, SGI.1027, fdcyd",0.440093374963888,0.1944991418416,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",-0.39409,-0.938,0.553,815,0.782,"idoxuridine, famciclovir, cidofovir, trifluridine, cephalomannine",0.257274868695302,0.106793246940152,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.36723,-0.879,0.624,1299,0.841,"artemisinin, mitomycin.c, floxuridine",0.204815410317576,0.0752040042020878,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",-0.47507,-1.14,0.289,877,0.648,"domperidone, acetophenazine, lurasidone, isofloxythepin, oxiperomide, sertindole, clebopride, UH.232...., remoxipride, thioproperazine",0.539102157243452,0.188424994129407,FALSE
+"H520","Pearson.est","estrogen receptor agonist",0.27235,0.774,0.75,23,0.972,"estradiol",0.1249387366083,0.0123337350737254,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",-0.64022,-1.51,0.0562,1136,0.269,"tamoxifen, raloxifene, clomifene",1.25026368443094,0.570247719997592,FALSE
+"H520","Pearson.est","FGFR inhibitor",0.55896,1.57,0.0704,312,0.297,"erdafitinib, MK.2461, dovitinib, nintedanib, AZD4547",1.15242734085789,0.527243550682788,FALSE
+"H520","Pearson.est","FLT3 inhibitor",0.24133,0.707,0.822,54,0.974,"ponatinib, gilteritinib",0.0851281824599496,0.0114410431213845,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",-0.62488,-1.47,0.0557,1100,0.283,"desonide, fludroxycortide, triamcinolone, difluprednate, fluticasone.propionate, methylprednisolone, halobetasol.propionate, ciclesonide, dexamethasone.acetate, triamcinolone.acetonide, prednisolone, rimexolone, deflazacort, halcinonide, flumethasone.pivalate, betamethasone, hydrocortisone",1.25414480482627,0.54821356447571,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",-0.32414,-0.762,0.785,1400,0.938,"ACDPP, IEM1754",0.105130343254747,0.0277971616209356,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.23211,0.652,0.905,1114,0.945,"CHIR.98014, tideglusib, TWS.119, AZD2858, GSK.3.inhibitor.IX, LY2090314, CHIR.99021, kenpaullone, indirubin",0.0433514207947967,0.0245681914907371,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.64264,-1.57,0.0369,1150,0.203,"GSK1904529A, lestaurtinib, GW.441756, danusertib",1.43297363384094,0.692503962086787,TRUE
+"H520","Pearson.est","HCV inhibitor",0.26068,0.731,0.829,34,0.972,"Ro.9187",0.0814454694497265,0.0123337350737254,FALSE
+"H520","Pearson.est","HDAC inhibitor",-0.41168,-0.99,0.485,937,0.726,"R306465, pyroxamide, PCI.24781, trichostatin.a, M.344, scriptaid, vorinostat, NSC.3852, nexturastat.a, SB.939, RGFP966, ACY.1215",0.314258261397736,0.139063379299906,FALSE
+"H520","Pearson.est","histamine receptor antagonist",-0.2545,-0.607,0.93,1026,1,"epinastine, chloropyramine, astemizole, ebastine, terfenadine, levocetirizine",0.0315170514460649,0,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.60423,1.76,0.0372,82,0.344,"lovastatin, pitavastatin",1.4294570601181,0.46344155742847,FALSE
+"H520","Pearson.est","HSP inhibitor",-0.42905,-1.02,0.435,1155,0.735,"alvespimycin, KW.2478, XL888, tanespimycin",0.361510743045363,0.133712660915805,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.46602,-1.11,0.331,951,0.639,"CEP.33779, TG.02, WHI.P154, pacritinib, AZ960, LY2784544, atiprimod, lestaurtinib, filgotinib, AT.9283",0.480172006224281,0.1944991418416,FALSE
+"H520","Pearson.est","KIT inhibitor",0.34408,0.952,0.466,25,0.731,"dasatinib, telatinib",0.33161408331,0.13608262304214,FALSE
+"H520","Pearson.est","MDM inhibitor",-0.7337,-1.73,0.0138,1058,0.262,"serdemetan, AMG.232, RITA, idasanutlin, nutlin.3, CGM097",1.86012091359876,0.581698708680255,FALSE
+"H520","Pearson.est","MEK inhibitor",-0.18988,-0.443,0.986,572,0.992,"arctigenin, trametinib, selumetinib, MEK1.2.inhibitor, AZD8330, TAK.733, AS.703026, MEK162, U.0126, PD.98059, PD.318088, Ro.4987655, PD.0325901, PD.198306",0.0061230850587888,0.00348832784582135,FALSE
+"H520","Pearson.est","MET inhibitor",0.78849,2.27,0.00508,311,0.0551,"LY2801653, PHA.665752, PF.04217903, INC.280, NVP.BVU972, AMG458",2.29413628771608,1.25884840114821,TRUE
+"H520","Pearson.est","microtubule inhibitor",-0.49083,-1.18,0.261,1209,0.674,"colchicine, podophyllotoxin, D.64131, cabazitaxel",0.583359492661719,0.17134010346468,FALSE
+"H520","Pearson.est","mTOR inhibitor",-0.30897,-0.725,0.827,753,0.965,"PI.103, torin.1, ku.0063794, voxtalisib, torin.2, AZD2014, deforolimus, PF.04691502, PKI.179, WAY.600, XL388, WYE.125132, GSK2126458, LY303511, PF.05212384, AZD8055",0.0824944904474534,0.0154726866562074,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",-0.53228,-1.25,0.205,1282,0.6,"bindarit, parthenolide...., IKK.2.inhibitor.V, EVP4593",0.688246138944246,0.221848749616356,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.4362,1.24,0.225,819,0.551,"BW.180C, salvinorin.a, spiradoline, trimebutine, ADL5859, cebranopadol",0.647817481888638,0.258848401148215,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.71449,-1.7,0.0115,1184,0.166,"skepinone.l, CMPD.1, SB.239063, talmapimod",1.93930215964639,0.779891911959945,TRUE
+"H520","Pearson.est","PARP inhibitor",-0.37099,-0.884,0.609,1120,0.855,"AG.14361, niraparib, PJ.34",0.215382707367125,0.0680338852718274,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.52052,1.51,0.0989,169,0.258,"dasatinib, ponatinib, telatinib, CP.673451, motesanib, dovitinib",1.00480370840282,0.58838029403677,FALSE
+"H520","Pearson.est","phosphatase inhibitor",0.39743,1.12,0.299,66,0.563,"BVT.948, bis.maltolato.oxovanadium.IV.",0.52432881167557,0.249491605148654,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",0.40934,1.16,0.241,16,0.603,"YM.976, GSK256066",0.617982957425132,0.219682687859849,FALSE
+"H520","Pearson.est","PI3K inhibitor",-0.3075,-0.724,0.823,984,0.945,"PF.04691502, alpelisib, PKI.179, YM.201636, AZD6482, CUDC.907, GSK2126458, LY303511, PIK.75, PF.05212384, taselisib",0.0846001647877302,0.0245681914907371,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.66025,-1.57,0.0375,1253,0.203,"GW.843682X, NMS.1286937, HMN.214",1.42596873227228,0.692503962086787,TRUE
+"H520","Pearson.est","potassium channel blocker",0.32986,0.92,0.528,181,0.759,"mepivacaine, dofetilide",0.277366077466188,0.11975822410452,FALSE
+"H520","Pearson.est","PPAR receptor agonist",-0.34944,-0.839,0.668,999,0.887,"oleoylethanolamide, ciprofibrate, GW.501516",0.175223537524454,0.0520763801682736,FALSE
+"H520","Pearson.est","progesterone receptor agonist",-0.20882,-0.488,0.971,1082,1,"tanaproget, levonorgestrel",0.0127807700919951,0,FALSE
+"H520","Pearson.est","proteasome inhibitor",-0.52142,-1.23,0.217,902,0.617,"ixazomib, ONX.0914, delanzomib, oprozomib, ixazomib.citrate, MG.132",0.66354026615147,0.209714835966758,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.54336,-1.29,0.172,956,0.612,"tedizolid.phosphate, thiostrepton, clofoctol, chloramphenicol.palmitate, methacycline, azomycin..2.nitroimidazole., homoharringtonine, anguidine, cycloheximide, harringtonine, puromycin, bruceantin",0.764471553092451,0.213248577854439,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.54195,-1.28,0.174,964,0.599,"PP.121, BMS.599626, NVP.TAE226, AV.412, mubritinib, CP.724714",0.7594507517174,0.222573177610689,FALSE
+"H520","Pearson.est","RAF inhibitor",-0.47818,-1.14,0.304,755,0.648,"LGX818, sorafenib, RAF265, TAK.632, vemurafenib, GDC.0879, AZ.628, CEP.32496, PLX.4720",0.517126416391246,0.188424994129407,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",0.38626,1.13,0.26,26,0.58,"vandetanib",0.585026652029182,0.236572006437063,FALSE
+"H520","Pearson.est","retinoid receptor agonist",-0.41996,-0.998,0.466,1401,0.733,"bexarotene",0.33161408331,0.134896025358872,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",0.24757,0.696,0.847,1092,0.956,"fludarabine, hydroxyurea, pentostatin, fludarabine.phosphate, triapine, clofarabine, cytarabine, LY2334737, cladribine, gemcitabine",0.0721165896692931,0.0195421077238999,FALSE
+"H520","Pearson.est","serotonin receptor agonist",-0.65895,-1.57,0.0357,1447,0.203,"aripiprazole",1.44733178388781,0.692503962086787,TRUE
+"H520","Pearson.est","serotonin receptor antagonist",-0.48779,-1.15,0.294,1180,0.715,"SB.228357, sertindole, aripiprazole",0.531652669587843,0.145693958198919,FALSE
+"H520","Pearson.est","sodium channel blocker",-0.4294,-0.998,0.464,1034,0.733,"A.803467, benzocaine, brivaracetam, mexiletine, benzethonium",0.333482019445119,0.134896025358872,FALSE
+"H520","Pearson.est","src inhibitor",0.39621,1.16,0.25,83,0.603,"dasatinib, PP.1",0.602059991327962,0.219682687859849,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",0.25867,0.739,0.761,1075,0.996,"terconazole, ketoconazole, lanoconazole, sulconazole, posaconazole, chlormidazole",0.118615343229427,0.00174066157630127,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",-0.68568,-1.62,0.0223,1382,0.256,"D.4476, SB.525334",1.65169513695184,0.59176003468815,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",-0.62398,-1.48,0.057,1094,0.291,"carmofur, trifluridine, raltitrexed",1.24412514432751,0.536107011014093,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",-0.26563,-0.641,0.88,819,0.993,"etoposide.phosphate, licochalcone.a, teniposide, amsacrine, doxorubicin, etoposide, valrubicin, SN.38, amonafide, dexrazoxane, exatecan.mesylate, epirubicin, TAS.103, voreloxin",0.0555173278498314,0.00305075150461883,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.72364,-1.72,0.00768,1281,0.192,"podophyllotoxin, flubendazole, combretastatin.A.4, mebendazole, albendazole, dolastatin.10, parbendazole, plinabulin, vinorelbine, epothilone.b, KX2.391, CYT.997, indibulin, nocodazole, taltobulin, ABT.751, vincristine",2.11463877996849,0.71669877129645,TRUE
+"H520","Pearson.est","tyrosine kinase inhibitor",-0.24902,-0.591,0.922,936,0.992,"tyrphostin.AG.99, PP.121, BMS.599626, NVP.TAE226, apatinib, UNC2250, AV.412, mubritinib, GTP.14564, CP.724714",0.0352690789463706,0.00348832784582135,FALSE
+"H520","Pearson.est","VEGFR inhibitor",0.23028,0.656,0.896,212,0.973,"foretinib, telatinib, vandetanib, MK.2461, motesanib, dovitinib, MGCD.265, tivozanib",0.0476919903378748,0.0118871597316481,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",0.36711,1.02,0.406,919,0.71,"maxacalcitol, calcitriol, alfacalcidol, tacalcitol, paricalcitol, doxercalciferol, ercalcitriol",0.391473966422806,0.148741651280925,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",0.41751,0.978,0.491,661,0.68,"CUDC.101, TAK.285, tucatinib, GW.583340, WZ.4002, BIBU.1361, afatinib, AEE788, XL.647, rociletinib, osimertinib, ARRY.334543, CP.724714, lapatinib, PD.153035, AZD8931, neratinib, WZ8040, OSI.420, dovitinib, AST.1306, BIBX.1382, dacomitinib, BMS.690514, vandetanib, poziotinib, gefitinib",0.308918507877032,0.167491087293764,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",0.38037,0.88,0.633,420,0.769,"tozasertib, bafetinib, imatinib, KW.2449, ponatinib",0.198596289982645,0.114073660198569,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",-0.4466,-1.26,0.184,644,0.515,"pilocarpine, oxiracetam, nefiracetam, xanomeline, nicotine, tremorine",0.735182176990464,0.288192770958809,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.35919,-1,0.406,1088,0.662,"darifenacin, hyoscyamine, iododexetimide, dicycloverine, methscopolamine",0.391473966422806,0.1791420105603,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",0.54429,1.26,0.185,518,0.509,"CGS.15943, MRS.1220, PSB.1115, SCH.58261, theophylline",0.732828271596986,0.293282217663241,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",-0.21144,-0.621,0.957,303,1,"ritodrine, metaraminol, buphenine, clenbuterol, isoetharine, midodrine, terbutaline, norepinephrine, lidamidine, isoxsuprine, A61603, oxymetazoline, methyldopa, epinephrine, xylazine",0.0190880622231565,0,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",0.32081,0.75,0.774,411,0.873,"atipamezole, oxprenolol, dihydroergocristine, practolol, vincamine, atenolol......",0.111259039317107,0.0589857562944303,FALSE
+"HCC15","Pearson.est","AKT inhibitor",0.68003,1.56,0.0267,234,0.227,"uprosertib, GDC.0068, A.674563, AZD5363, MK.2206, GSK2110183, ONC201",1.57348873863542,0.643974142806877,TRUE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.4623,1.07,0.39,208,0.636,"DMH1, CEP.37440, AZD3463, crizotinib",0.408935392973501,0.196542884351586,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.77199,-2.18,0,1195,0.0275,"nilutamide, cyproterone.acetate, enzalutamide, flutamide",Inf,1.56066730616974,TRUE
+"HCC15","Pearson.est","antioxidant",-0.40499,-1.18,0.198,584,0.465,"chlorogenic.acid, trolox, benfotiamine, taurine, mesna, rutin",0.703334809738469,0.332547047110046,FALSE
+"HCC15","Pearson.est","AP inhibitor",-0.84798,-2.26,0,1351,0.0189,"idronoxil, birinapant, LCL.161, GDC.0152",Inf,1.72353819582676,TRUE
+"HCC15","Pearson.est","ATPase inhibitor",-0.37367,-1.03,0.401,1403,0.697,"digitoxigenin, digitoxin, ouabain, k.strophanthidin",0.396855627379818,0.156767221901991,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",0.69245,1.59,0.0235,395,0.208,"barasertib, tozasertib, CCT137690, ZM.447439, aurora.a.inhibitor.i, barasertib.HQPA, AMG900, hesperadin, SNS.314, MK.8745, CCT129202, PHA.680632, danusertib, ENMD.2076, AT.9283, KW.2449, alisertib, TAK.901, GSK1070916",1.62893213772826,0.681936665037238,TRUE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.51891,1.21,0.237,621,0.604,"valnemulin, azalomycin.b, azithromycin, dirithromycin, tedizolid",0.625251653989896,0.218963061378868,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.25871,0.603,0.927,475,0.947,"novobiocin, nadifloxacin",0.0329202658555029,0.0236500209967266,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.60108,1.4,0.0941,436,0.348,"gossypol, TW.37, oridonin, obatoclax, HA14.1",1.02641037657274,0.458420756053419,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.39374,0.89,0.643,61,0.77,"tozasertib, bafetinib",0.191789027075778,0.113509274827518,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.36692,0.855,0.676,353,0.793,"ivermectin, ZK.93423, zaleplon, piperazine",0.170053304058364,0.100726812682396,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.90985,2.12,0.00126,136,0.00169,"I.BET151, JQ1...., OTX015, I.BET.762, bromosporine, PFI.1",2.89962945488244,2.77211329538633,TRUE
+"HCC15","Pearson.est","calcium channel blocker",0.51684,1.2,0.215,545,0.602,"carboxyamidotriazole, mibefradil, penfluridol, SR.33805, pranidipine, tetrandrine, fendiline",0.667561540084395,0.220403508742175,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.6147,1.43,0.0775,177,0.314,"ZK811752, PF.04136309, SB.225002",1.11069829749369,0.503070351926785,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.63411,1.46,0.0625,345,0.305,"indisulam, TG.02, palbociclib, abemaciclib, BMS.387032, ribociclib, P276.00, JNJ.7706621, arcyriaflavin.a, dinaciclib, AT.7519, R547, alvocidib, kenpaullone, aminopurvalanol.a",1.20411998265592,0.515700160653214,FALSE
+"HCC15","Pearson.est","CHK inhibitor",0.28903,0.677,0.879,187,0.901,"SB.218078",0.0560111249262281,0.045275209020937,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.19552,-0.529,0.993,279,1,"curcumin, ketoprofen, aspirin, piroxicam, ramifenazone, tepoxalin, pterostilbene, meloxicam, FR.122047, tryptanthrin, suxibuzone, phenazone, indoprofen, naproxen, phenylbutazone, amfenac, FK.3311, sulfasalazine, acetylsalicylsalicylic.acid, metoxibutropate, AM.404",0.00305075150461883,0,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",-0.53195,-1.54,0.0714,1232,0.349,"itraconazole, clotrimazole, metyrapone, morin, eplerenone",1.14630178822383,0.45717457304082,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",0.44755,1.04,0.414,270,0.646,"mitomycin.c, estramustine, melphalan, TH.302, satraplatin",0.382999658879101,0.189767482004916,FALSE
+"HCC15","Pearson.est","DNA inhibitor",0.58046,1.34,0.121,406,0.402,"melphalan, oxaliplatin, pibenzimol, primaquine, chlorambucil, valrubicin, metronidazole, teroxirone, mechlorethamine, bendamustine",0.91721462968355,0.39577394691553,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.79751,1.86,0.0049,238,0.0246,"fdcyd, azacitidine, decitabine, SGI.1027",2.30980391997149,1.60906489289662,TRUE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.46033,1.07,0.392,438,0.636,"trifluridine, idoxuridine, adefovir.dipivoxil, cephalomannine, foscarnet",0.406713932979543,0.196542884351586,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",0.47997,1.12,0.325,143,0.669,"cyclocytidine, mitomycin.c, anisomycin, artesunate, enocitabine",0.488116639021126,0.174573882232177,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",0.3083,0.73,0.829,91,0.879,"sertindole, lurasidone",0.0814454694497265,0.0560111249262281,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.30278,-0.859,0.605,436,0.733,"estradiol, equol, estrone, erteberel, PPT, ethinyl.estradiol, levonorgestrel, estradiol.cypionate",0.218244625347531,0.134896025358872,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",0.47995,1.11,0.33,195,0.648,"clomifene, fulvestrant",0.481486060122112,0.188424994129407,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.41964,0.981,0.499,530,0.691,"regorafenib, nintedanib, PD.173074, dovitinib, lucitanib",0.30189945437661,0.160521952625802,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.58143,1.36,0.112,313,0.409,"sorafenib, tozasertib, pacritinib, TG.02, quizartinib, TG.101348, ENMD.2076, KW.2449",0.950781977329818,0.388276691992658,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.27288,-0.755,0.739,1312,0.87,"fluocinolone.acetonide, piretanide, dexamethasone.acetate, hydrocortisone",0.131355561605174,0.0604807473813815,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",-0.69175,-1.93,0.00505,1137,0.095,"MTPG, IEM1754, felbamate, diazooxonorleucine, CPP, tiletamine, kynurenic.acid, SIB.1757, latrepirdine, JNJ.16259685",2.29670862188134,1.02227639471115,TRUE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.42537,-1.21,0.223,1330,0.552,"CHIR.98014, tideglusib, indirubin",0.651695136951839,0.258060922270801,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",0.63201,1.46,0.0539,260,0.305,"GSK1838705A, AZD3463, danusertib",1.26841123481326,0.515700160653214,FALSE
+"HCC15","Pearson.est","HCV inhibitor",0.47425,1.11,0.333,617,0.648,"Ro.9187, mericitabine, PSI.7976",0.47755576649368,0.188424994129407,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.80156,1.87,0,226,0.0297,"R306465, givinostat, M.344, resminostat, scriptaid, dacinostat, AR.42, PCI.24781, chidamide, SB.939, belinostat, trichostatin.a, entinostat, vorinostat, panobinostat, pyroxamide, RG2833, RGFP966",Inf,1.52724355068279,TRUE
+"HCC15","Pearson.est","histamine receptor antagonist",-0.18957,-0.525,0.98,1444,0.98,"zolantidine",0.00877392430750515,0.00877392430750515,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",-0.83735,-2.36,0,1233,0.0206,"lovastatin, atorvastatin, mevastatin, pitavastatin, fluvastatin",Inf,1.68613277963085,TRUE
+"HCC15","Pearson.est","HSP inhibitor",0.50298,1.16,0.277,505,0.648,"NMS.E973, NVP.AUY922, tanespimycin, SNX.5422, ganetespib, BIIB021, SNX.2112, XL888",0.557520230935551,0.188424994129407,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.44892,1.03,0.45,318,0.648,"tozasertib, pacritinib, TG.02, TG.101348, AT.9283, PRT062070",0.346787486224656,0.188424994129407,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.4637,1.07,0.389,355,0.636,"regorafenib, sorafenib, pazopanib, motesanib, imatinib, KI.8751, telatinib, OSI.930",0.410050398674292,0.196542884351586,FALSE
+"HCC15","Pearson.est","MDM inhibitor",-0.30702,-0.878,0.542,1227,0.733,"CGM097, AMG.232, idasanutlin",0.266000713461613,0.134896025358872,FALSE
+"HCC15","Pearson.est","MEK inhibitor",0.22585,0.516,0.981,826,0.975,"nobiletin, trametinib, arctigenin, AS.703026, cobimetinib, AZD8330, PD.0325901, TAK.733, U.0126, MEK162, selumetinib, PD.184352, Ro.4987655",0.0083309926200515,0.0109953843014632,FALSE
+"HCC15","Pearson.est","MET inhibitor",-0.33681,-0.965,0.485,1393,0.69,"PF.04217903",0.314258261397736,0.161150909262745,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.43194,1,0.461,182,0.672,"D.64131, vinflunine",0.336299074610352,0.172630726946175,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",0.41699,0.965,0.515,738,0.689,"torin.2, WYE.125132, GSK2126458, PF.05212384, GDC.0980, AZD2014, everolimus, MLN0128, XL388, LY303511, NVP.BEZ235, PI.103, PKI.179, ku.0063794, WYE.354, AZD8055, temsirolimus, LY3023414, PP242, palomid.529, PF.04691502",0.288192770958809,0.161780778092374,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.49384,1.14,0.317,382,0.647,"EVP4593, betulinic.acid, curcumin, bortezomib, Ro.106.9920, parthenolide....",0.498940737782249,0.1890957193313,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",-0.55045,-1.53,0.0629,1213,0.304,"ADL5859, spiradoline, cebranopadol, BW.180C",1.20134935455473,0.517126416391246,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",0.32999,0.758,0.793,548,0.88,"talmapimod, SB.239063, SB.242235, skepinone.l",0.100726812682396,0.0555173278498314,FALSE
+"HCC15","Pearson.est","PARP inhibitor",0.5528,1.28,0.16,380,0.488,"niraparib, talazoparib, olaparib, PJ.34",0.795880017344075,0.311580177997289,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.47233,1.09,0.349,599,0.671,"regorafenib, sorafenib, pazopanib, trapidil, motesanib, axitinib, imatinib, KI.8751, telatinib, nintedanib, ponatinib, vatalanib, dovitinib, sunitinib, masitinib, crenolanib, CP.673451",0.45717457304082,0.173277479831008,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.33167,0.765,0.777,295,0.889,"mycophenolic.acid, mycophenolate.mofetil, GSK2830371",0.109578981199086,0.0510982390297863,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.32648,-0.935,0.521,1136,0.705,"enoximone, EMD.53998, GSK256066, anagrelide",0.283162276700476,0.151810883008601,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",0.49155,1.14,0.303,484,0.647,"CUDC.907, taselisib, CH5132799, buparlisib, YM.201636, GSK2126458, alpelisib, BGT226, PF.05212384, GDC.0980, PI3K.IN.2, PIK.75, LY303511, NVP.BEZ235, PI.103",0.518557371497695,0.1890957193313,FALSE
+"HCC15","Pearson.est","PLK inhibitor",0.8217,1.89,0,235,0.0347,"volasertib, GW.843682X, BI.2536, NMS.1286937, GSK461364, rigosertib",Inf,1.45967052520913,TRUE
+"HCC15","Pearson.est","potassium channel blocker",-0.48256,-1.42,0.133,1122,0.387,"dofetilide, ibutilide, mepivacaine, meglitinide",0.876148359032914,0.412289034981089,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.36017,-1,0.402,519,0.662,"oleoylethanolamide, GW.501516, pterostilbene, ciprofibrate, S26948, fenofibrate, clofibrate",0.39577394691553,0.1791420105603,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.42412,-1.19,0.244,1204,0.489,"levonorgestrel, danazol, norethindrone.acetate, norethindrone",0.612610173661271,0.31069114087638,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.39279,0.902,0.614,626,0.767,"carfilzomib, bortezomib, delanzomib, ONX.0914",0.211831628858832,0.115204636051019,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.46433,1.08,0.359,188,0.672,"anguidine, bruceantin, homoharringtonine, thiostrepton, azomycin..2.nitroimidazole.",0.444905551421681,0.172630726946175,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.58377,1.35,0.107,397,0.405,"NVP.TAE226, tyrphostin.A9, mubritinib, CP.724714",0.97061622231479,0.392544976785331,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.66,1.53,0.0431,298,0.255,"regorafenib, sorafenib, TAK.632, SB.590885, GDC.0879, AZ.628, RAF265",1.36552272983927,0.593459819566045,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.69013,1.59,0.0299,163,0.208,"regorafenib, sorafenib, cabozantinib",1.52432881167557,0.681936665037238,TRUE
+"HCC15","Pearson.est","retinoid receptor agonist",0.67601,1.6,0.0272,360,0.276,"fenretinide, adarotene, bexarotene, CD.437, tamibarotene, AM.580",1.5654310959658,0.559090917934782,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.44563,1.04,0.415,742,0.646,"LY2334737, clofarabine, fludarabine, pentostatin, gemcitabine, fludarabine.phosphate, triapine, cladribine",0.381951903287907,0.189767482004916,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",-0.40391,-1.19,0.227,1208,0.489,"SR.57227A, aripiprazole, NAN.190",0.643974142806877,0.31069114087638,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",0.39675,0.909,0.604,91,0.771,"sertindole, lurasidone",0.218963061378868,0.112945621949043,FALSE
+"HCC15","Pearson.est","sodium channel blocker",0.35678,0.827,0.718,517,0.819,"ajmaline, benzethonium, butamben, triamterene, lappaconite, brivaracetam",0.1438755557577,0.0867160982395816,FALSE
+"HCC15","Pearson.est","src inhibitor",-0.50248,-1.41,0.0955,1397,0.349,"saracatinib, dasatinib",1.01999662841625,0.45717457304082,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",-0.30715,-0.878,0.567,1338,0.733,"terconazole, lanoconazole",0.246416941107093,0.134896025358872,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.31781,0.724,0.825,596,0.87,"LY2109761, adaprev, D.4476",0.0835460514500749,0.0604807473813815,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.6286,1.44,0.0626,504,0.32,"raltitrexed, trifluridine, doxifluridine, ftorafur, carmofur",1.20342566678957,0.494850021680094,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",0.6338,1.48,0.0664,508,0.325,"irinotecan, idarubicin, topotecan, exatecan.mesylate, genz.644282, rubitecan, daunorubicin, doxorubicin, epirubicin, valrubicin, TAS.103, SN.38, amonafide, teniposide, beta.lapachone, amsacrine, camptothecin, etoposide.phosphate, etoposide, nemorubicin, mitoxantrone",1.17783192063198,0.488116639021126,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.44039,1.02,0.45,725,0.651,"albendazole, taltobulin, docetaxel, fosbretabulin, parbendazole, vinorelbine, paclitaxel, vindesine, combretastatin.A.4, fenbendazole, indibulin, vincristine, podophyllotoxin, verubulin, BNC105, KX2.391, nocodazole, oxibendazole, flubendazole, vinblastine, dolastatin.10",0.346787486224656,0.186419011431808,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.51733,1.19,0.254,262,0.599,"regorafenib, NVP.TAE226, sorafenib, bafetinib, cabozantinib, tyrphostin.A9, hypericin, UNC2250, tivantinib, mubritinib",0.595166283380062,0.222573177610689,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.46613,1.06,0.396,574,0.639,"regorafenib, foretinib, sorafenib, golvatinib, pazopanib, cabozantinib, motesanib, axitinib, ENMD.2076, RAF265, KI.8751, AEE788, XL.647, telatinib, OSI.930, nintedanib, PD.173074, vatalanib, dovitinib, lucitanib, sunitinib, tivozanib",0.402304814074488,0.1944991418416,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",0.55656,1.29,0.164,646,0.49,"maxacalcitol, tacalcitol, alfacalcidol, paricalcitol, calcitriol, ercalcitriol, doxercalciferol",0.785156151952302,0.309803919971486,FALSE
+"H460","Pearson.est","EGFR inhibitor",0.16222,0.499,1,234,0.988,"poziotinib, pelitinib, AZD8931, vandetanib, gefitinib, BMS.690514, icotinib, PD.168393, tyrphostin.AG.494, dacomitinib, lapatinib, AEE788, canertinib, salvianolic.acid.B",0,0.00524305541237188,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.28599,-0.652,0.897,771,1,"flumatinib, metatinib, ZM.306416, bafetinib, bosutinib, nilotinib, imatinib, tozasertib, KW.2449",0.0472075569559079,0,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.67782,-1.57,0.0321,1049,0.217,"oxiracetam, nefiracetam, xanomeline, pilocarpine",1.49349496759513,0.66354026615147,TRUE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.78975,2.41,0,301,0.0114,"hyoscyamine, diphemanil, darifenacin, iododexetimide, dicycloverine",Inf,1.94309514866353,TRUE
+"H460","Pearson.est","adenosine receptor antagonist",0.32269,0.925,0.577,983,0.798,"istradefylline, SCH.58261, MRS.1220, CGS.15943, sulmazole, PSB.1115, theophylline",0.238824186844269,0.0979971086492706,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",-0.21203,-0.488,0.985,1363,1,"midodrine",0.00656376950238827,0,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",-0.31153,-0.729,0.829,1018,1,"naftidrofuryl, dronedarone, atipamezole, carvedilol, levobunolol, idazoxan, oxprenolol",0.0814454694497265,0,FALSE
+"H460","Pearson.est","AKT inhibitor",-0.55866,-1.27,0.166,830,0.611,"AT7867, GDC.0068, palomid.529, MK.2206, CCT128930, AZD5363, ONC201, A.674563, triciribine, uprosertib",0.779891911959945,0.213958789757446,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27634,-0.639,0.908,827,1,"NVP.TAE684, AP26113, AZD3463, alectinib, DMH1",0.0419141514789149,0,FALSE
+"H460","Pearson.est","androgen receptor antagonist",0.6276,1.84,0.0214,543,0.165,"nilutamide, bicalutamide, flutamide, enzalutamide, RU.58841, cyproterone.acetate",1.66958622665081,0.782516055786094,TRUE
+"H460","Pearson.est","antioxidant",-0.43117,-0.993,0.486,833,0.875,"trolox, benfotiamine, taurine",0.313363730737707,0.0579919469776868,FALSE
+"H460","Pearson.est","AP inhibitor",-0.37278,-0.855,0.691,926,1,"embelin, tanshinone.i, LCL.161",0.160521952625802,0,FALSE
+"H460","Pearson.est","ATPase inhibitor",-0.29431,-0.677,0.892,1137,1,"digoxin, NMS.873, evodiamine, oligomycin.a",0.0496351456238769,0,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.71116,-1.65,0.0216,1142,0.229,"tozasertib, PHA.680632, barasertib, CYC116, KW.2449, GSK1070916, PF.03814735, danusertib, alisertib, ENMD.2076, AMG900, MK.8745, CCT137690, SNS.314, barasertib.HQPA, AT.9283, hesperadin, ZM.447439",1.66554624884907,0.640164517660112,TRUE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.41774,-0.949,0.529,896,0.936,"josamycin, radezolid, azalomycin.b, valnemulin",0.276544327964814,0.0287241512618947,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.30972,0.936,0.514,1002,0.845,"sarafloxacin, sparfloxacin, finafloxacin, novobiocin, trovafloxacin, nadifloxacin, norfloxacin, lomefloxacin",0.289036881004724,0.0731432910503077,FALSE
+"H460","Pearson.est","BCL inhibitor",-0.36481,-0.836,0.714,1256,1,"gossypol, TW.37",0.146301788223826,0,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",0.24909,0.717,0.803,4,0.996,"dasatinib",0.095284454721319,0.00174066157630127,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.21484,0.665,0.931,109,1,"gamma.aminobutyric.acid, eprinomectin, temazepam",0.0310503190186574,0,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.92649,-2.12,0,1336,0.000904,"bromosporine, I.BET.762, PFI.1, I.BET151, JQ1...., OTX015",Inf,3.04383156952464,TRUE
+"H460","Pearson.est","calcium channel blocker",-0.61246,-1.41,0.0777,1085,0.473,"penfluridol, mibefradil, tetrandrine, SR.33805, carboxyamidotriazole",1.10957898119909,0.325138859262188,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.5472,-1.24,0.185,1010,0.667,"ZK811752, navarixin, PF.04136309, SB.225002",0.732828271596986,0.175874166083451,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.69966,-1.63,0.0185,1112,0.154,"P276.00, alvocidib, kenpaullone, aminopurvalanol.a, TG.02, AZD5438, BMS.265246, JNJ.7706621, BMS.387032, PHA.793887, palbociclib, abemaciclib, dinaciclib, ribociclib, AT.7519, indisulam, R547",1.73282827159699,0.812479279163537,TRUE
+"H460","Pearson.est","CHK inhibitor",-0.50792,-1.17,0.265,778,0.746,"CHIR.124, LY2603618, LY2606368, AZD7762, PF.477736, SB.218078",0.576754126063192,0.127261172527331,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.16784,-0.39,0.995,960,0.998,"ramifenazone, phenazone, aspirin, FR.122047, acetylsalicylsalicylic.acid, tryptanthrin",0.00217691925427455,0.000869458712628891,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",0.5535,1.68,0.0227,120,0.221,"morin, eplerenone, metyrapone",1.64397414280688,0.655607726314889,TRUE
+"H460","Pearson.est","DNA alkylating agent",-0.50625,-1.16,0.283,1247,0.743,"estramustine, TH.302, streptozotocin, satraplatin, mitomycin.c",0.54821356447571,0.129011186239425,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.35517,-0.821,0.741,946,1,"mechlorethamine, teroxirone, melphalan, valrubicin, pibenzimol, primaquine, oxaliplatin",0.130181792020672,0,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.61168,-1.38,0.0894,898,0.477,"disulfiram, SGI.1027, decitabine, azacitidine, fdcyd",1.04866248120408,0.321481620959886,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",-0.48187,-1.12,0.311,1158,0.743,"adefovir.dipivoxil, idoxuridine, cephalomannine, trifluridine",0.507239610973163,0.129011186239425,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.45553,-1.05,0.413,1331,0.829,"anisomycin, cyclocytidine, mitomycin.c",0.384049948343599,0.0814454694497265,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",-0.25215,-0.576,0.946,648,1,"thioproperazine, piperacetazine, paliperidone, oxiperomide, raclopride, lurasidone, UH.232...., acetophenazine, sertindole",0.0241088635982073,0,FALSE
+"H460","Pearson.est","estrogen receptor agonist",0.41944,1.26,0.176,844,0.456,"ethinyl.estradiol, estradiol.cypionate, levonorgestrel, PPT, estrone, equol, estradiol, erteberel",0.75448733218585,0.341035157335565,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",-0.45128,-1.03,0.426,773,0.855,"danazol, raloxifene, toremifene, clomifene",0.370590400897281,0.0680338852718274,FALSE
+"H460","Pearson.est","FGFR inhibitor",-0.4501,-1.02,0.443,1248,0.855,"regorafenib, lucitanib",0.35359627377693,0.0680338852718274,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.49698,-1.14,0.301,1142,0.742,"tozasertib, TG.101348, TG.02, KW.2449, pacritinib, sorafenib, ENMD.2076",0.521433504406157,0.129596094720973,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",0.28039,0.82,0.684,1049,0.881,"hydrocortisone, triamcinolone.acetonide, piretanide, fluocinolone.acetonide, desonide, prednisolone.acetate, halcinonide, clobetasol.propionate, rimexolone, ciclesonide, flumethasone, betamethasone, beclomethasone.dipropionate, triamcinolone, halobetasol.propionate, dexamethasone.acetate, methylprednisolone, prednisolone.hemisuccinate, difluprednate, fluticasone.propionate, prednisolone, flumethasone.pivalate, fluorometholone, fludroxycortide, deflazacort",0.164943898279884,0.0550240915879521,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.47851,1.36,0.12,52,0.442,"latrepirdine, SIB.1757, JNJ.16259685, kynurenic.acid, CGP.37849",0.920818753952375,0.354577730650908,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.20858,-0.483,0.983,1119,1,"AZD2858, kenpaullone",0.00744648216786438,0,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.571,-1.32,0.125,870,0.572,"PHA.848125, AZD3463, lestaurtinib, GW.441756, GSK1838705A, danusertib",0.903089986991944,0.242603971206976,FALSE
+"H460","Pearson.est","HCV inhibitor",-0.58901,-1.35,0.104,1298,0.521,"mericitabine, narlaprevir",0.98296666070122,0.283162276700476,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.63847,-1.46,0.065,1046,0.376,"RGFP966, RG2833, R306465, belinostat, dacinostat, SB.939, PCI.24781, chidamide, entinostat, NSC.3852, resminostat, M.344, AR.42, givinostat, vorinostat, mocetinostat, scriptaid, trichostatin.a",1.18708664335714,0.424812155072339,FALSE
+"H460","Pearson.est","histamine receptor antagonist",-0.26133,-0.6,0.949,991,1,"ebastine, pheniramine, chloropyramine, terfenadine, tiotidine, levocetirizine",0.0227337875727074,0,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.43828,1.31,0.154,816,0.444,"pitavastatin, simvastatin, lovastatin, fluvastatin, atorvastatin, mevastatin",0.812479279163537,0.35261702988538,FALSE
+"H460","Pearson.est","HSP inhibitor",-0.45917,-1.06,0.391,1096,0.829,"VER.49009, alvespimycin, XL888, PU.H71, tanespimycin",0.407823242604133,0.0814454694497265,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.47959,-1.1,0.349,873,0.772,"filgotinib, CEP.33779, PRT062070, lestaurtinib, baricitinib, tozasertib, TG.101348, TG.02, TG.101209, AZ960, pacritinib, AT.9283",0.45717457304082,0.112382699664264,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.43006,-0.991,0.486,1034,0.856,"imatinib, vatalanib, pazopanib, KI.8751, regorafenib, sorafenib, OSI.930",0.313363730737707,0.0675262353228468,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.39566,-0.912,0.592,1070,0.998,"RITA, serdemetan",0.22767829327708,0.000869458712628891,FALSE
+"H460","Pearson.est","MEK inhibitor",-0.31095,-0.714,0.853,1071,1,"PD.98059, BIX.02188, arctigenin, nobiletin",0.069050968832477,0,FALSE
+"H460","Pearson.est","MET inhibitor",0.4836,1.48,0.0735,321,0.356,"PF.04217903, NVP.BVU972, PHA.665752, LY2801653, INC.280",1.1337126609158,0.448550002027125,FALSE
+"H460","Pearson.est","microtubule inhibitor",-0.70341,-1.63,0.0181,1280,0.154,"colchicine, vinflunine, podophyllotoxin, cabazitaxel, D.64131",1.74232142513082,0.812479279163537,TRUE
+"H460","Pearson.est","mTOR inhibitor",-0.25068,-0.581,0.958,548,1,"LY3023414, ku.0063794, SB.2343, GDC.0980, PI.103, torin.1, WAY.600, voxtalisib, PF.05212384, deforolimus, MLN0128, PKI.179, palomid.529, WYE.354, WYE.125132, GSK2126458, XL388, AZD2014, LY303511, AZD8055, torin.2",0.0186344909214556,0,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",-0.59938,-1.39,0.0986,1251,0.49,"IKK.2.inhibitor.V, bortezomib, parthenolide...., EVP4593, betulinic.acid",1.00612308505879,0.309803919971486,FALSE
+"H460","Pearson.est","opioid receptor agonist",0.33388,0.975,0.454,257,0.924,"BW.180C, ADL5859, cebranopadol, spiradoline",0.342944147142896,0.0343280287798933,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",-0.57063,-1.31,0.13,937,0.565,"SB.242235, CMPD.1, VX.702, SB.239063, talmapimod",0.886056647693163,0.247951552180562,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.51468,-1.19,0.259,894,0.752,"AZD2461, E7449, PJ.34, olaparib, talazoparib, niraparib",0.586700235918748,0.123782159408358,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.39097,-0.899,0.611,981,1,"SU014813, CP.673451, imatinib, axitinib, vatalanib, pazopanib, crenolanib, KI.8751, trapidil, regorafenib, sorafenib",0.213958789757446,0,FALSE
+"H460","Pearson.est","phosphatase inhibitor",-0.26258,-0.614,0.924,958,1,"CID.5458317, GSK2830371, mycophenolate.mofetil, mycophenolic.acid",0.0343280287798933,0,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",-0.26779,-0.611,0.926,1308,1,"trequinsin",0.0333890133180656,0,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.19127,-0.444,0.991,847,1,"AZD6482, BGT226, TG.100713, taselisib, buparlisib, GSK2126458, YM.201636, CUDC.907, LY303511, PIK.75",0.00392634551472468,0,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.84733,-1.96,0,1221,0.00994,"rigosertib, HMN.214, volasertib, GSK461364, NMS.1286937, GW.843682X, BI.2536",Inf,2.00261361560269,TRUE
+"H460","Pearson.est","potassium channel blocker",-0.30262,-0.696,0.886,1041,1,"ML133, oleoylethanolamide",0.0525662781129492,0,FALSE
+"H460","Pearson.est","PPAR receptor agonist",0.22623,0.663,0.865,1122,0.943,"fenofibrate, pterostilbene, GW.501516, S26948, clofibrate, ciprofibrate, oleoylethanolamide",0.0629838925351858,0.0254883072626717,FALSE
+"H460","Pearson.est","progesterone receptor agonist",-0.21538,-0.502,0.981,1040,1,"melengestrol.acetate, dienogest",0.0083309926200515,0,FALSE
+"H460","Pearson.est","proteasome inhibitor",-0.47395,-1.09,0.347,711,0.772,"MG.132, carfilzomib, oprozomib, ixazomib.citrate, delanzomib, ixazomib, bortezomib",0.459670525209126,0.112382699664264,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.51462,-1.17,0.251,1089,0.746,"cycloheximide, tedizolid.phosphate, puromycin, homoharringtonine, thiostrepton, harringtonine, anguidine, bruceantin",0.600326278518962,0.127261172527331,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.48394,-1.12,0.324,1123,0.743,"mubritinib, tyrphostin.A9, NVP.TAE226",0.489454989793388,0.129011186239425,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.55589,-1.28,0.163,1237,0.617,"PLX.4720, regorafenib, TAK.632, RAF265, sorafenib",0.787812395596042,0.209714835966758,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.52481,-1.21,0.22,1248,0.721,"regorafenib, sorafenib",0.657577319177794,0.142064735280571,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.33156,-0.758,0.796,1364,1,"bexarotene",0.0990869322623309,0,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.50641,-1.14,0.288,969,0.742,"pentostatin, fludarabine, fludarabine.phosphate, cladribine, gemcitabine, clofarabine",0.540607512240769,0.129596094720973,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.38582,-0.891,0.623,1176,0.994,"zolmitriptan, aripiprazole",0.20551195334083,0.00261361560268669,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.43438,-1.01,0.473,934,0.856,"lurasidone, SB.216641, SB.228357, RS.16566, aripiprazole, sertindole",0.325138859262188,0.0675262353228468,FALSE
+"H460","Pearson.est","sodium channel blocker",-0.3504,-0.81,0.757,887,1,"triamterene, brivaracetam, A.803467, mexiletine, ajmaline, lappaconite, benzethonium",0.120904120499927,0,FALSE
+"H460","Pearson.est","src inhibitor",0.37847,1.14,0.234,23,0.623,"dasatinib, saracatinib",0.630784142589857,0.20551195334083,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",0.28988,0.83,0.662,1030,0.93,"lanoconazole, posaconazole, terconazole, sulconazole, ketoconazole, chlormidazole",0.1791420105603,0.0315170514460649,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",-0.32206,-0.748,0.796,471,1,"adaprev, SB.431542, LY2109761, D.4476, SB.525334",0.0990869322623309,0,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.71737,-1.66,0.0115,1057,0.279,"capecitabine, doxifluridine, carmofur, trifluridine, raltitrexed",1.93930215964639,0.554395796726402,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.61817,-1.46,0.0564,1078,0.376,"daunorubicin, idarubicin, topotecan, valrubicin, beta.lapachone, rubitecan, amsacrine, teniposide, amonafide, camptothecin, genz.644282, etoposide, SN.38, licochalcone.a, voreloxin, TAS.103, exatecan.mesylate",1.24872089601666,0.424812155072339,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.71289,-1.63,0.0219,1229,0.154,"indibulin, plinabulin, verubulin, paclitaxel, docetaxel, vinorelbine, dolastatin.10, combretastatin.A.4, vincristine, podophyllotoxin, parbendazole, nocodazole, epothilone.b, fosbretabulin, taltobulin, CYT.997, flubendazole, ABT.751, KX2.391, albendazole",1.65955588515988,0.812479279163537,TRUE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.38504,-0.871,0.657,1080,1,"tyrphostin.AG.99, mubritinib, aminopurvalanol.a, tyrphostin.A9, regorafenib, tivantinib, NVP.TAE226, UNC2250, sorafenib",0.182434630440219,0,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.37053,-0.848,0.699,931,1,"foretinib, cabozantinib, SU014813, axitinib, vatalanib, pazopanib, golvatinib, KI.8751, regorafenib, RAF265, lucitanib, sorafenib, OSI.930, ENMD.2076",0.155522824254319,0,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",0.33657,0.964,0.455,963,0.856,"calcitriol, paricalcitol, maxacalcitol, alfacalcidol, doxercalciferol, tacalcitol, ercalcitriol",0.341988603342888,0.0675262353228468,FALSE
+"A549","Pearson.est","EGFR inhibitor",-0.22171,-0.531,0.972,1045,1,"dovitinib, WZ.4002, tyrphostin.AG.1478, CGP.52411, PD.153035, BIBX.1382, WZ8040, CUDC.101, GW.583340, BMS.690514",0.0123337350737254,0,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",-0.54434,-1.31,0.145,1284,0.615,"bafetinib, tozasertib, bosutinib",0.838631997765025,0.211124884224583,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",-0.60374,-1.46,0.0856,1253,0.689,"nefiracetam, tremorine, pilocarpine",1.06752623532285,0.161780778092374,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",-0.65232,-1.59,0.0182,1121,0.923,"darifenacin, methscopolamine, dicycloverine",1.73992861201493,0.0347982989740879,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",-0.58887,-1.41,0.111,1088,0.676,"MRS.1220, SCH.58261, PSB.1115, CGS.15943",0.954677021213343,0.170053304058364,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",-0.45309,-1.08,0.376,1334,0.767,"isoetharine, lidamidine, clenbuterol, oxymetazoline, buphenine",0.424812155072339,0.115204636051019,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",-0.36477,-0.883,0.61,776,0.85,"pindolol, prazosin, RS.17053, vincamine, atenolol...., carvedilol, idazoxan, dronedarone, naftidrofuryl, levobunolol, atipamezole, practolol",0.214670164989233,0.0705810742857073,FALSE
+"A549","Pearson.est","AKT inhibitor",-0.56846,-1.37,0.122,1132,0.655,"AZD5363, A.674563, GSK2110183, CCT128930, GDC.0068, uprosertib, triciribine",0.913640169325252,0.183758700008217,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.15379,0.433,1,1227,0.996,"AP26113, GW.788388, brigatinib, SB.505124, DMH1, alectinib, CEP.37440, NVP.TAE684, AZD3463, lorlatinib, crizotinib",0,0.00174066157630127,FALSE
+"A549","Pearson.est","androgen receptor antagonist",-0.61886,-1.51,0.0703,1124,1,"cyproterone.acetate, flutamide, enzalutamide",1.15304467498018,0,FALSE
+"A549","Pearson.est","antioxidant",0.21914,0.593,0.935,1132,1,"rutin, mesna, trolox, taurine, chlorogenic.acid, benfotiamine",0.0291883891274822,0,FALSE
+"A549","Pearson.est","AP inhibitor",0.68493,1.97,0.0114,166,0.16,"idronoxil, embelin, LCL.161, GDC.0152",1.94309514866353,0.795880017344075,TRUE
+"A549","Pearson.est","ATPase inhibitor",0.30904,0.871,0.598,90,0.899,"k.strophanthidin, digitoxin, ouabain",0.223298816011589,0.0462403082667712,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.54511,-1.32,0.162,878,0.634,"danusertib, CYC116, ZM.447439, SNS.314, AMG900, GSK1070916, PF.03814735, AT.9283, PHA.680632, aurora.a.inhibitor.i, barasertib, alisertib, barasertib.HQPA, MLN.8054, tozasertib, MK.8745, CCT129202, CCT137690, hesperadin",0.790484985457369,0.197910742118267,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.29103,-0.717,0.83,1191,0.96,"valnemulin, radezolid",0.0809219076239261,0.0177287669604316,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.34219,0.953,0.485,228,0.927,"lomefloxacin, trovafloxacin",0.314258261397736,0.0329202658555029,FALSE
+"A549","Pearson.est","BCL inhibitor",0.33791,0.898,0.522,35,0.891,"obatoclax, venetoclax",0.282329496997738,0.0501222959631252,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.60892,-1.46,0.0645,1284,0.689,"bafetinib, tozasertib, bosutinib",1.19044028536473,0.161780778092374,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",-0.52276,-1.27,0.182,1167,0.641,"indiplon, ZK.93423, lorazepam, nefiracetam, temazepam",0.739928612014925,0.193141970481183,FALSE
+"A549","Pearson.est","bromodomain inhibitor",-0.43342,-1.05,0.395,683,0.779,"bromosporine, OTX015, I.BET.762, I.BET151, JQ1....",0.40340290437354,0.108462542327436,FALSE
+"A549","Pearson.est","calcium channel blocker",-0.50068,-1.2,0.253,949,0.666,"pranidipine, efonidipine.monoethanolate, SR.33805, penfluridol, tetrandrine, cinnarazine",0.596879478824182,0.176525770829699,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",-0.57928,-1.36,0.119,1258,0.573,"RS.504393, ZK811752, PF.04136309",0.924453038607469,0.24184537803261,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.51592,-1.24,0.219,1012,0.638,"aminopurvalanol.a, CR8..R., JNJ.7706621, abemaciclib, ribociclib, BMS.387032, R547, arcyriaflavin.a, dinaciclib, BMS.265246, TG.02, AZD5438",0.659555885159882,0.195179321278838,FALSE
+"A549","Pearson.est","CHK inhibitor",-0.57618,-1.39,0.117,951,0.662,"SCH.900776, SB.218078, LY2606368, AZD7762, CHIR.124",0.931814138253838,0.1791420105603,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",0.22342,0.615,0.903,153,1,"AM.404, acetylsalicylsalicylic.acid, metoxibutropate, amfenac",0.0443122496864942,0,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",0.36678,1,0.458,84,0.878,"eplerenone, clotrimazole",0.339134521996131,0.0565054840938974,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.33751,-0.819,0.692,715,0.896,"ifosfamide, cyclophosphamide, temozolomide, carboplatin, dianhydrogalactitol, mitomycin.c, carmustine, cisplatin, satraplatin, TH.302",0.159893905543242,0.0476919903378748,FALSE
+"A549","Pearson.est","DNA inhibitor",0.23375,0.643,0.878,127,1,"sangivamycin, bendamustine, melphalan",0.0565054840938974,0,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",-0.34927,-0.84,0.665,1371,0.883,"decitabine",0.177178354696895,0.0540392964224314,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",-0.2871,-0.694,0.848,1419,0.928,"foscarnet",0.0716041477432862,0.0324520237811379,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.38306,-0.905,0.602,996,0.854,"mitomycin.c, enocitabine, CB.10.277, cisplatin, cyclocytidine, anisomycin, artesunate",0.220403508742175,0.068542129310995,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",-0.32359,-0.77,0.73,1082,0.95,"acetophenazine, isofloxythepin, sertindole, mesoridazine, nemonapride, piperacetazine",0.136677139879544,0.0222763947111523,FALSE
+"A549","Pearson.est","estrogen receptor agonist",0.38054,1.02,0.425,332,0.965,"levonorgestrel, equol, PPT, erteberel, estradiol.cypionate",0.371611069949688,0.0154726866562074,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.42006,1.15,0.273,281,0.883,"danazol, toremifene, tamoxifen, raloxifene",0.563837352959244,0.0540392964224314,FALSE
+"A549","Pearson.est","FGFR inhibitor",0.38258,1.03,0.375,273,1,"erdafitinib, lucitanib, orantinib, lenvatinib, AZD4547",0.425968732272281,0,FALSE
+"A549","Pearson.est","FLT3 inhibitor",-0.56413,-1.36,0.124,1175,0.573,"gilteritinib, quizartinib, midostaurin, sorafenib, pacritinib, TG.02, tozasertib, TG.101348",0.906578314837765,0.24184537803261,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",0.24596,0.669,0.873,1098,1,"hydrocortisone, betamethasone, piretanide, triamcinolone, triamcinolone.acetonide, prednisolone.hemisuccinate, halcinonide, fluocinolone.acetonide, deflazacort, flumethasone, flumethasone.pivalate, ciclesonide, desonide, fluorometholone, prednisolone, dexamethasone.acetate, rimexolone, fluticasone.propionate, difluprednate, fludroxycortide, halobetasol.propionate, prednisolone.acetate, methylprednisolone, beclomethasone.dipropionate, clobetasol.propionate",0.0589857562944303,0,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.21245,0.573,0.935,349,1,"felbamate, tiletamine, LY456236, MTPG, diazooxonorleucine, CPP, kynurenic.acid",0.0291883891274822,0,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",0.18226,0.491,0.989,101,1,"tideglusib",0.0048037084028206,0,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",0.39486,1.08,0.344,879,0.981,"GW.441756, GSK1838705A, lestaurtinib, GSK1904529A, AZD3463, PHA.848125, danusertib",0.46344155742847,0.0083309926200515,FALSE
+"A549","Pearson.est","HCV inhibitor",0.44735,1.23,0.206,66,0.888,"narlaprevir, embelin",0.686132779630847,0.051587034221399,FALSE
+"A549","Pearson.est","HDAC inhibitor",-0.62214,-1.48,0.069,1087,0.915,"chidamide, entinostat, trichostatin.a, mocetinostat, dacinostat, belinostat, romidepsin, vorinostat, R306465, SB.939, RGFP966, M.344, panobinostat, resminostat, AR.42, givinostat, scriptaid",1.16115090926274,0.0385789059335517,FALSE
+"A549","Pearson.est","histamine receptor antagonist",0.28724,0.78,0.681,82,1,"zolantidine, ebastine, astemizole",0.166852888087215,0,FALSE
+"A549","Pearson.est","HMGCR inhibitor",0.56258,1.53,0.0889,180,0.454,"pitavastatin, atorvastatin, mevastatin, fluvastatin",1.05109823902979,0.342944147142896,FALSE
+"A549","Pearson.est","HSP inhibitor",-0.47254,-1.13,0.329,1039,0.771,"VER.49009, NVP.AUY922, alvespimycin, guanidine, tanespimycin",0.482804102050026,0.112945621949043,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.47599,-1.13,0.322,1046,0.771,"AZ960, AT.9283, WHI.P154, TG.101209, pacritinib, TG.02, tozasertib, TG.101348",0.492144128304169,0.112945621949043,FALSE
+"A549","Pearson.est","KIT inhibitor",-0.44811,-1.07,0.389,1122,0.761,"telatinib, midostaurin, pazopanib, KI.8751, sorafenib",0.410050398674292,0.118615343229427,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.47102,-1.12,0.332,783,0.762,"nutlin.3, CGM097, serdemetan, RITA",0.478861916295964,0.1180450286604,FALSE
+"A549","Pearson.est","MEK inhibitor",0.3419,0.934,0.498,268,0.912,"TAK.733, cobimetinib, MEK162, Ro.4987655, selumetinib, PD.318088, AZD8330, U.0126",0.302770657240282,0.0400051616715838,FALSE
+"A549","Pearson.est","MET inhibitor",-0.50455,-1.21,0.252,1130,0.675,"LY2801653, INC.280",0.598599459218456,0.170696227168975,FALSE
+"A549","Pearson.est","microtubule inhibitor",-0.27771,-0.674,0.876,641,0.932,"vinblastine, triclabendazole, cytochalasin.b, secnidazole, colchicine, vinflunine, D.64131",0.0574958938319193,0.0305840876460186,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.52775,-1.26,0.197,1128,0.627,"NVP.BEZ235, AZD8055, torin.2, LY3023414, SB.2343, PP242, temsirolimus, PKI.179, MLN0128, WYE.354, WYE.125132, everolimus",0.705533773838407,0.202732459169284,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",-0.35647,-0.852,0.663,1343,0.883,"EVP4593, betulinic.acid",0.178486471595227,0.0540392964224314,FALSE
+"A549","Pearson.est","opioid receptor agonist",0.58519,1.66,0.0602,141,0.346,"ADL5859, BW.180C, cebranopadol",1.22040350874218,0.460923901207223,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",-0.31134,-0.741,0.801,1112,0.97,"TAK.715, SB.242235",0.0963674839157623,0.0132282657337552,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.46143,-1.1,0.343,974,0.749,"AG.14361, niraparib, PJ.34, endo.IWR.1",0.464705879957229,0.125518182300534,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.40195,-0.964,0.495,1045,0.835,"dovitinib, axitinib, telatinib, pazopanib, KI.8751, sorafenib, CP.673451, crenolanib",0.305394801066431,0.0783135245163979,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.30319,-0.731,0.793,1254,0.962,"AS.1949490, mycophenolate.mofetil",0.100726812682396,0.0168249279621871,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",-0.28597,-0.67,0.882,1300,0.919,"zardaverine, avanafil",0.0545314148681803,0.0366844886138887,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.37422,-0.896,0.59,939,0.848,"AZD6482, GDC.0980, CH5132799, BGT226, TG.100713, YM.201636, buparlisib, NVP.BEZ235, GDC.0941, CUDC.907, LY3023414, PI3K.IN.2, SB.2343, PKI.179",0.229147988357856,0.0716041477432862,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.39191,-0.93,0.556,1032,0.853,"volasertib, GW.843682X",0.254925208417942,0.069050968832477,FALSE
+"A549","Pearson.est","potassium channel blocker",0.21082,0.571,0.955,1144,1,"mepivacaine, meglitinide, dofetilide, oleoylethanolamide, ibutilide, ML133",0.0199966284162537,0,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.34629,0.927,0.527,949,0.874,"clofibrate, fenofibrate, S26948, oleoylethanolamide, pterostilbene, GW.501516, ciprofibrate",0.278189384787453,0.058488567365597,FALSE
+"A549","Pearson.est","progesterone receptor agonist",0.38427,1.01,0.394,45,0.917,"danazol, levonorgestrel",0.404503778174426,0.0376306643299789,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.67506,1.81,0.0369,213,0.243,"oprozomib, ONX.0914, ixazomib.citrate, ixazomib",1.43297363384094,0.614393726401688,TRUE
+"A549","Pearson.est","protein synthesis inhibitor",-0.40454,-0.966,0.496,1205,0.857,"thiostrepton, mercaptopurine, emetine, chloramphenicol.palmitate, azomycin..2.nitroimidazole., florfenicol",0.304518323509803,0.0670191780768018,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.40576,-0.995,0.459,1115,0.845,"mubritinib, tyrphostin.A9, NVP.TAE226",0.338187314462739,0.0731432910503077,FALSE
+"A549","Pearson.est","RAF inhibitor",0.27038,0.744,0.775,116,1,"vemurafenib, AZ.628",0.11069829749369,0,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.45371,-1.11,0.336,829,0.755,"regorafenib, vandetanib, apatinib, sorafenib",0.473660722610156,0.122053048370812,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.48975,1.32,0.149,136,0.783,"adarotene, tamibarotene, LE.135",0.826813731587726,0.106238237942057,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.15465,-0.376,1,1096,1,"LY2334737, cytarabine",0,0,FALSE
+"A549","Pearson.est","serotonin receptor agonist",0.83488,2.33,0,13,0.022,"aripiprazole, NAN.190",Inf,1.65757731917779,TRUE
+"A549","Pearson.est","serotonin receptor antagonist",0.45206,1.2,0.253,1,0.85,"aripiprazole",0.596879478824182,0.0705810742857073,FALSE
+"A549","Pearson.est","sodium channel blocker",-0.53419,-1.27,0.192,1263,0.641,"A.803467, benzocaine, butamben, ajmaline",0.71669877129645,0.193141970481183,FALSE
+"A549","Pearson.est","src inhibitor",-0.40016,-0.972,0.493,1374,0.871,"bosutinib",0.30715308072277,0.0599818449923368,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",-0.58229,-1.43,0.097,990,0.695,"sulconazole, posaconazole, chlormidazole, terconazole",1.01322826573376,0.158015195409886,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",-0.42433,-1.03,0.426,786,0.796,"SB.431542, SB.525334, adaprev",0.370590400897281,0.0990869322623309,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",-0.28678,-0.701,0.825,905,0.939,"ftorafur, doxifluridine, trifluridine",0.0835460514500749,0.0273344077338891,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.38482,-0.932,0.552,828,0.874,"voreloxin, SN.38, daunorubicin, doxorubicin, valrubicin, fleroxacin, amonafide, etoposide, camptothecin, amsacrine, irinotecan, rubitecan, teniposide, exatecan.mesylate, genz.644282, TAS.103, idarubicin",0.258060922270801,0.058488567365597,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",-0.15251,-0.369,0.999,1338,0.999,"flubendazole, albendazole",0.000434511774017692,0.000434511774017692,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",-0.38672,-0.927,0.533,1012,0.836,"aminopurvalanol.a, apatinib, mubritinib, tyrphostin.A9, UNC2250, bafetinib, sorafenib, NVP.TAE226, tyrphostin.AG.99, hypericin",0.273272790973428,0.0777937225609836,FALSE
+"A549","Pearson.est","VEGFR inhibitor",-0.29677,-0.713,0.822,1221,0.944,"pazopanib, KI.8751, sorafenib, golvatinib, BMS.690514, MGCD.265, foretinib, tivozanib",0.0851281824599496,0.025028005701931,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",-0.74254,-1.77,0.00846,1070,0.449,"alfacalcidol, doxercalciferol, maxacalcitol, calcitriol, ercalcitriol, tacalcitol, paricalcitol",2.07262963696098,0.347753658996677,FALSE
+"HCC44","Pearson.est","EGFR inhibitor",0.46963,1.29,0.167,272,0.428,"tucatinib, dovitinib, AEE788, poziotinib, AZD8931, dacomitinib, lapatinib, BMS.690514, neratinib, CUDC.101, pelitinib, vandetanib, afatinib, osimertinib, TAK.285, GW.583340, XL.647",0.777283528852417,0.368556230986828,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",-0.5153,-1.24,0.217,897,0.767,"GZD824, metatinib, dasatinib, flumatinib, KW.2449, ZM.306416, nilotinib, bosutinib",0.66354026615147,0.115204636051019,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",-0.63549,-1.56,0.0409,1384,0.353,"tremorine, pilocarpine",1.38827669199266,0.452225294612177,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.2683,-0.668,0.908,1130,0.985,"dicycloverine, methscopolamine",0.0419141514789149,0.00656376950238827,FALSE
+"HCC44","Pearson.est","adenosine receptor antagonist",0.40549,1.1,0.315,95,0.517,"CGS.15943, MRS.1220",0.501689446210399,0.286509456906058,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.41466,-1.01,0.451,874,0.836,"oxymetazoline, norepinephrine, terbutaline, epinephrine, xylazine, clenbuterol, isoetharine, A61603, isoxsuprine, midodrine",0.345823458122039,0.0777937225609836,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",0.25514,0.696,0.835,12,0.937,"practolol, atenolol......",0.0783135245163979,0.0282604091122217,FALSE
+"HCC44","Pearson.est","AKT inhibitor",0.49673,1.38,0.126,84,0.393,"GDC.0068, uprosertib, GSK2110183, MK.2206",0.899629454882437,0.405607449624573,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.3415,-0.825,0.668,1420,0.977,"AP26113",0.175223537524454,0.0101054362812269,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",-0.63654,-1.58,0.0319,1043,0.361,"enzalutamide, cyproterone.acetate, bicalutamide, flutamide",1.49620931694282,0.442492798094342,FALSE
+"HCC44","Pearson.est","antioxidant",-0.6745,-1.64,0.0421,1028,0.298,"rutin, mesna, trolox, benfotiamine, taurine",1.37571790416433,0.525783735923745,FALSE
+"HCC44","Pearson.est","AP inhibitor",-0.7244,-1.81,0.0135,1247,0.189,"idronoxil, GDC.0152, LCL.161",1.86966623150499,0.723538195826756,TRUE
+"HCC44","Pearson.est","ATPase inhibitor",-0.45006,-1.1,0.355,1253,0.714,"blebbistatin...., digitoxigenin, digitoxin",0.449771646944906,0.146301788223826,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.26338,-0.638,0.89,683,0.996,"CCT129202, MK.5108, AMG900, ENMD.2076, alisertib, danusertib, SNS.314, AT.9283, GSK1070916, CCT137690, barasertib.HQPA, ZM.447439, PF.03814735, hesperadin, KW.2449, MK.8745, CYC116",0.0506099933550872,0.00174066157630127,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.21319,0.59,0.924,1141,1,"azithromycin, azalomycin.b, valnemulin, dirithromycin, tilmicosin, tedizolid, radezolid, josamycin",0.0343280287798933,0,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.28852,-0.708,0.827,1018,0.978,"finafloxacin, norfloxacin, lomefloxacin",0.0824944904474534,0.00966114521239857,FALSE
+"HCC44","Pearson.est","BCL inhibitor",0.74335,2.02,0.0143,336,0.0575,"HA14.1, TW.37, gossypol, navitoclax, obatoclax, oridonin, ABT.737",1.84466396253494,1.24033215531037,TRUE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.48265,-1.17,0.268,897,0.69,"GZD824, metatinib, dasatinib, flumatinib, nilotinib, bosutinib",0.571865205971211,0.161150909262745,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.36798,-0.905,0.578,997,0.903,"nefiracetam, temazepam, indiplon, lorazepam, CGS.20625",0.238072161579471,0.0443122496864942,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",0.78849,2.12,0.00412,311,0.038,"I.BET151, I.BET.762, OTX015, JQ1...., PFI.1, bromosporine",2.38510278396687,1.42021640338319,TRUE
+"HCC44","Pearson.est","calcium channel blocker",0.40334,1.11,0.296,435,0.575,"SR.33805, pranidipine, mibefradil, carboxyamidotriazole, fendiline, penfluridol, SKF.96365",0.528708288941061,0.24033215531037,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.40335,-0.978,0.493,1158,0.879,"RS.504393, MK.0812, navarixin",0.30715308072277,0.0560111249262281,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.26024,-0.637,0.9,1012,0.959,"indirubin, PHA.848125, AZD5438, alvocidib, aminopurvalanol.a, CR8..R., PHA.793887, BMS.265246",0.0457574905606751,0.0181813928293364,FALSE
+"HCC44","Pearson.est","CHK inhibitor",-0.72986,-1.79,0.00396,1177,0.153,"PF.477736, CHIR.124, SCH.900776, AZD7762, LY2606368",2.40230481407449,0.815308569182401,TRUE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.26619,-0.636,0.883,937,0.942,"tryptanthrin, aspirin, FR.122047, metoxibutropate, phenazone, amfenac, sulfasalazine, acetylsalicylsalicylic.acid, FK.3311",0.0540392964224314,0.0259490972071227,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.5345,-1.3,0.166,1008,0.683,"eplerenone, clotrimazole, metyrapone, itraconazole",0.779891911959945,0.165579296318467,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",-0.46407,-1.15,0.29,1408,0.68,"carboplatin, streptozotocin",0.537602002101044,0.167491087293764,FALSE
+"HCC44","Pearson.est","DNA inhibitor",0.28408,0.798,0.686,231,0.897,"chlorambucil, metronidazole, melphalan, bendamustine, pibenzimol, carmustine",0.163675884293248,0.0472075569559079,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",0.41154,1.16,0.3,355,0.533,"azacitidine, disulfiram, fdcyd, SGI.1027",0.522878745280338,0.273272790973428,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.49019,-1.21,0.244,846,0.688,"trifluridine, famciclovir, idoxuridine, cephalomannine, foscarnet",0.612610173661271,0.162411561764489,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",-0.53086,-1.31,0.169,1329,0.705,"capecitabine, cyclocytidine, altretamine",0.772113295386326,0.151810883008601,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.53777,-1.34,0.159,1195,0.67,"remoxipride, isofloxythepin, UH.232...., thioproperazine, acetophenazine, piperacetazine, raclopride",0.798602875679548,0.173925197299174,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",-0.33373,-0.809,0.711,1435,0.981,"estradiol.cypionate",0.148130399270234,0.0083309926200515,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",-0.73878,-1.77,0.0108,1193,0.134,"tamoxifen, danazol, raloxifene",1.96657624451305,0.872895201635192,TRUE
+"HCC44","Pearson.est","FGFR inhibitor",0.51394,1.42,0.112,145,0.387,"dovitinib, PD.173074, regorafenib, lenvatinib, erdafitinib",0.950781977329818,0.412289034981089,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",0.28783,0.821,0.668,271,0.901,"dovitinib, sunitinib, quizartinib, TG.02, pacritinib, TG.101348, sorafenib",0.175223537524454,0.045275209020937,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.37827,-0.931,0.569,956,0.9,"flumethasone, triamcinolone, prednisolone.acetate, fludroxycortide, fluticasone.propionate, flumethasone.pivalate, fluocinolone.acetonide, dexamethasone.acetate, fluorometholone, hydrocortisone",0.244887733604929,0.0457574905606751,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",-0.49883,-1.21,0.246,1168,0.688,"latrepirdine, LY456236, JNJ.16259685, tiletamine, IEM1754, SIB.1757",0.609064892896621,0.162411561764489,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.5602,-1.37,0.127,915,0.632,"CHIR.98014, indirubin, GSK.3.inhibitor.IX, LY2090314, AZD2858, tideglusib, TWS.119",0.896196279044043,0.199282921717615,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.46594,-1.13,0.323,763,0.697,"danusertib, lestaurtinib, GW.441756, PHA.848125, GSK1904529A",0.490797477668897,0.156767221901991,FALSE
+"HCC44","Pearson.est","HCV inhibitor",-0.28295,-0.677,0.856,809,0.996,"daclatasvir, mericitabine, narlaprevir",0.0675262353228468,0.00174066157630127,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",0.24263,0.698,0.849,69,0.976,"tacedinaline, R306465, RGFP966",0.0710923097560473,0.0105501823333082,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",-0.38027,-0.932,0.567,1179,0.925,"levocetirizine, terfenadine, BF2.649, tiotidine, zolantidine, famotidine",0.246416941107093,0.0338582672609674,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",-0.76687,-1.91,0.00135,1142,0.124,"lovastatin, mevastatin, pitavastatin, fluvastatin",2.86966623150499,0.906578314837765,TRUE
+"HCC44","Pearson.est","HSP inhibitor",0.17017,0.488,0.987,164,0.986,"NMS.E973, BIIB021",0.00568284733036327,0.0061230850587888,FALSE
+"HCC44","Pearson.est","JAK inhibitor",-0.34657,-0.854,0.641,1208,0.948,"AZD1480, filgotinib, CEP.33779, WHI.P154",0.193141970481183,0.0231916626619338,FALSE
+"HCC44","Pearson.est","KIT inhibitor",0.39515,1.1,0.322,182,0.517,"motesanib, pazopanib, regorafenib, sunitinib, lenvatinib, masitinib",0.492144128304169,0.286509456906058,FALSE
+"HCC44","Pearson.est","MDM inhibitor",-0.28866,-0.71,0.823,1129,0.996,"CGM097",0.0846001647877302,0.00174066157630127,FALSE
+"HCC44","Pearson.est","MEK inhibitor",-0.49727,-1.22,0.227,815,0.782,"nobiletin, PD.98059, AZD8330, cobimetinib, BIX.02188, PD.0325901, Ro.4987655, TAK.733, MEK1.2.inhibitor, MEK162, PD.318088, PD.198306, refametinib, PD.184352",0.643974142806877,0.106793246940152,FALSE
+"HCC44","Pearson.est","MET inhibitor",-0.45586,-1.1,0.345,831,0.714,"PHA.665752, NVP.BVU972, LY2801653, PF.04217903",0.462180904926726,0.146301788223826,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",-0.60213,-1.46,0.0846,1187,0.55,"podophyllotoxin, secnidazole, D.64131, cabazitaxel, colchicine",1.07262963696098,0.259637310505756,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",0.46105,1.29,0.173,154,0.428,"PF.05212384, PI.103, GDC.0980, WYE.125132, temsirolimus, GSK2126458, OSI.027, sirolimus, everolimus",0.761953896871205,0.368556230986828,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",-0.24019,-0.59,0.931,1048,0.963,"tyloxapol, bindarit, parthenolide, IKK.2.inhibitor.V",0.0310503190186574,0.0163737128754655,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.58288,-1.41,0.107,913,0.639,"spiradoline, cebranopadol, ADL5859, BW.180C, trimebutine",0.97061622231479,0.1944991418416,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",-0.32432,-0.78,0.758,922,0.981,"talmapimod, VX.702, CMPD.1, TAK.715",0.120330794367946,0.0083309926200515,FALSE
+"HCC44","Pearson.est","PARP inhibitor",0.2021,0.576,0.963,358,0.984,"niraparib, talazoparib, olaparib, PJ.34",0.0163737128754655,0.00700490156865849,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.45186,1.28,0.212,182,0.405,"motesanib, dovitinib, pazopanib, regorafenib, linifanib, sunitinib, lenvatinib, masitinib",0.673664139071249,0.392544976785331,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",-0.37252,-0.908,0.557,1133,0.921,"CID.5458317, AS.1949490, bis.maltolato.oxovanadium.IV., BVT.948",0.254144804826271,0.0357403698031511,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.35827,-0.873,0.629,857,0.938,"EMD.53998, zardaverine, GSK256066, trequinsin, anagrelide, papaverine",0.201349354554731,0.0277971616209356,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",0.67351,1.87,0.0274,147,0.0857,"taselisib, alpelisib, CH5132799, PI3K.IN.2, PI.828, PF.05212384, PI.103, GDC.0980, GSK2126458, TG100.115, CUDC.907, GDC.0941, buparlisib",1.56224943717961,1.0670191780768,TRUE
+"HCC44","Pearson.est","PLK inhibitor",-0.46826,-1.16,0.271,986,0.684,"rigosertib, BI.2536, HMN.214, GSK461364",0.567030709125594,0.164943898279884,FALSE
+"HCC44","Pearson.est","potassium channel blocker",-0.44201,-1.07,0.393,1358,0.754,"meglitinide",0.405607449624573,0.122628654130226,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",0.34212,0.964,0.482,955,0.711,"pterostilbene, fenofibrate, S26948, ciprofibrate, oleoylethanolamide, clofibrate, GW.501516",0.31695296176115,0.148130399270234,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",-0.50012,-1.21,0.233,1059,0.688,"norethindrone.acetate, nomegestrol.acetate, norethindrone, danazol, dienogest",0.632644078973981,0.162411561764489,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",0.30069,0.859,0.653,205,0.875,"ONX.0914, carfilzomib, oprozomib",0.185086818724926,0.0579919469776868,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",-0.22448,-0.541,0.964,1344,0.976,"cycloheximide, mercaptopurine",0.0159229660971692,0.0105501823333082,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.38774,-0.957,0.506,1307,0.897,"PP.121",0.295849483160201,0.0472075569559079,FALSE
+"HCC44","Pearson.est","RAF inhibitor",-0.41693,-1.02,0.441,1170,0.841,"PLX.4720, LGX818, CEP.32496, vemurafenib",0.355561410532161,0.0752040042020878,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.8022,2.26,0.00356,271,0.0188,"regorafenib, sunitinib, cabozantinib, vandetanib, sorafenib",2.44855000202712,1.72584215073632,TRUE
+"HCC44","Pearson.est","retinoid receptor agonist",0.79764,2.26,0,28,0.0188,"adarotene, fenretinide, tamibarotene",Inf,1.72584215073632,TRUE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.29565,-0.735,0.78,801,0.984,"triapine, fludarabine, gemcitabine, clofarabine, fludarabine.phosphate, cladribine",0.10790539730952,0.00700490156865849,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.52213,-1.29,0.181,852,0.663,"SR.57227A, pardoprunox, aripiprazole, zolmitriptan",0.742321425130815,0.178486471595227,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.32414,-0.791,0.744,1145,0.987,"pirenperone, aripiprazole, SB.216641, RS.16566",0.128427064454121,0.00568284733036327,FALSE
+"HCC44","Pearson.est","sodium channel blocker",-0.26374,-0.637,0.883,916,0.959,"cibenzoline, benzocaine, lappaconite, oxcarbazepine, A.803467, mexiletine",0.0540392964224314,0.0181813928293364,FALSE
+"HCC44","Pearson.est","src inhibitor",-0.47032,-1.18,0.267,832,0.696,"PP.2, TG.100572, PP.1, dasatinib, KX2.391, ZM.306416, bosutinib",0.573488738635425,0.157390760389438,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",-0.49216,-1.2,0.241,1074,0.68,"lanoconazole, terconazole",0.617982957425132,0.167491087293764,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",0.24757,0.705,0.781,1091,1,"LY2109761, adaprev, SB.431542, D.4476, repsox, SB.525334",0.1073489661227,0,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.31439,-0.775,0.723,1329,0.967,"capecitabine",0.140861702705469,0.0145735259169983,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",-0.31153,-0.763,0.776,1257,0.964,"camptothecin, SN.38, etoposide, TAS.103, voreloxin, licochalcone.a",0.110138278741812,0.0159229660971692,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.55697,-1.37,0.127,829,0.632,"combretastatin.A.4, vincristine, oxibendazole, indibulin, vinorelbine, verubulin, BNC105, vinblastine, fenbendazole, albendazole, docetaxel, fosbretabulin, paclitaxel, KX2.391, podophyllotoxin, plinabulin, dolastatin.10, nocodazole, epothilone.d, epothilone.b, ABT.751, CYT.997, flubendazole",0.896196279044043,0.199282921717615,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.20618,-0.5,0.982,1044,0.978,"aminopurvalanol.a, dasatinib, GTP.14564, tyrphostin.AG.99, PP.121, AMG.208",0.00788851221305034,0.00966114521239857,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",0.49863,1.42,0.121,127,0.387,"foretinib, motesanib, dovitinib, AEE788, golvatinib, PD.173074, pazopanib, regorafenib, linifanib, BMS.690514, sunitinib, cabozantinib, lenvatinib",0.91721462968355,0.412289034981089,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",0.66585,1.87,0.015,290,0.0857,"maxacalcitol, calcitriol, tacalcitol, paricalcitol",1.82390874094432,1.0670191780768,TRUE
+"H1703","Pearson.est","EGFR inhibitor",-0.19448,-0.504,0.976,1056,0.998,"lapatinib, BMS.599626, erlotinib, GW.583340, icotinib, rociletinib, TAK.285, BIBX.1382, ARRY.334543, WZ8040, PD.153035, CNX.2006",0.0105501823333082,0.000869458712628891,FALSE
+"H1703","Pearson.est","Abl kinase inhibitor",-0.53393,-1.36,0.143,1079,0.653,"bosutinib, GZD824, ponatinib, imatinib, tozasertib, KW.2449, metatinib, ZM.306416",0.844663962534938,0.185086818724926,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",-0.49601,-1.25,0.209,890,0.622,"xanomeline, nefiracetam, tremorine, pilocarpine",0.679853713888946,0.206209615309181,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",0.63669,1.69,0.0353,473,0.324,"diphemanil, hyoscyamine, methscopolamine, darifenacin, iododexetimide",1.45222529461218,0.489454989793388,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",-0.35666,-0.916,0.549,1075,0.718,"theophylline, CGS.15943, istradefylline",0.260427655549908,0.1438755557577,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",0.24471,0.642,0.884,277,0.881,"xylazine, isoetharine, ritodrine, A61603, oxymetazoline",0.0535477349869269,0.0550240915879521,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",0.45552,1.2,0.248,395,0.523,"atenolol...., propranolol, metoprolol, imiloxan, prazosin, RS.17053, atenolol......, practolol, dihydroergocristine, dronedarone",0.605548319173784,0.281498311132726,FALSE
+"H1703","Pearson.est","AKT inhibitor",-0.45353,-1.17,0.285,1021,0.612,"MK.2206, CCT128930, uprosertib, AT7867, A.674563, ONC201, triciribine",0.54515513999149,0.213248577854439,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.50996,-1.3,0.182,999,0.639,"alectinib, AP26113, DMH1, crizotinib, CEP.37440, AZD3463",0.739928612014925,0.1944991418416,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",0.69906,1.8,0.0105,122,0.227,"nilutamide, flutamide, enzalutamide",1.97881070093006,0.643974142806877,TRUE
+"H1703","Pearson.est","antioxidant",-0.59911,-1.52,0.0772,1147,0.938,"benfotiamine, rutin, chlorogenic.acid",1.11238269966426,0.0277971616209356,FALSE
+"H1703","Pearson.est","AP inhibitor",-0.53333,-1.38,0.147,1269,0.739,"idronoxil, LCL.161",0.832682665251824,0.131355561605174,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.317,-0.804,0.695,967,0.783,"omeprazole, thonzonium, digitoxigenin, rabeprazole, digitoxin, digoxin",0.158015195409886,0.106238237942057,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.53204,-1.34,0.167,1084,0.596,"TAK.901, AMG900, CCT129202, CYC116, CCT137690, AT.9283, tozasertib, MK.5108, KW.2449, ZM.447439, GSK1070916, hesperadin",0.777283528852417,0.224753740259764,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.31223,0.826,0.653,453,0.768,"tilmicosin, josamycin, azithromycin, dirithromycin",0.185086818724926,0.114638779968488,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.72485,1.88,0.00223,343,0.402,"sparfloxacin, nadifloxacin, sarafloxacin, lomefloxacin, novobiocin, finafloxacin",2.65169513695184,0.39577394691553,FALSE
+"H1703","Pearson.est","BCL inhibitor",0.35381,0.942,0.53,156,0.712,"HA14.1, oridonin",0.275724130399211,0.147520006363144,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",-0.44875,-1.13,0.303,1079,0.583,"bosutinib, GZD824, ponatinib, imatinib, tozasertib, metatinib",0.518557371497695,0.234331445240986,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.40642,1.07,0.334,279,0.641,"gamma.aminobutyric.acid, CL.218872, bentazepam, temazepam",0.476253533188435,0.193141970481183,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",0.63731,1.66,0.0436,487,0.302,"I.BET151, I.BET.762, OTX015, bromosporine, JQ1....",1.36051351073141,0.519993057042849,FALSE
+"H1703","Pearson.est","calcium channel blocker",-0.55739,-1.41,0.108,1102,0.849,"tetrandrine, mibefradil, penfluridol, carboxyamidotriazole, SR.33805",0.96657624451305,0.0710923097560473,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.40228,-1.04,0.413,1396,0.629,"MK.0812, navarixin",0.384049948343599,0.201349354554731,FALSE
+"H1703","Pearson.est","CDK inhibitor",-0.53452,-1.35,0.151,1219,0.623,"palbociclib, abemaciclib, indirubin, alvocidib, PHA.848125, NU6027, PHA.793887, dinaciclib, AT.7519",0.821023052706831,0.20551195334083,FALSE
+"H1703","Pearson.est","CHK inhibitor",-0.68967,-1.78,0.0277,1329,0.868,"LY2606368, LY2603618, SCH.900776",1.55752023093555,0.0614802748235081,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",0.38283,1.01,0.411,209,0.682,"naproxen, piroxicam, metoxibutropate, FR.122047, tepoxalin, suxibuzone",0.386158178123931,0.166215625343521,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",0.62909,1.64,0.0585,177,0.275,"morin, PF.4981517",1.23284413391782,0.560667306169737,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.47959,-1.23,0.23,988,0.562,"ifosfamide, cisplatin, satraplatin, dianhydrogalactitol, streptozotocin, cyclophosphamide, estramustine, carboplatin, mitomycin.c",0.638272163982407,0.250263684430939,FALSE
+"H1703","Pearson.est","DNA inhibitor",0.43866,1.15,0.283,320,0.571,"tirapazamine, metronidazole, nimorazole, chlorambucil, bendamustine, nithiamide, busulfan, mechlorethamine, melphalan",0.54821356447571,0.243363891754152,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",-0.53963,-1.39,0.125,985,0.801,"disulfiram, fdcyd, RG108, decitabine",0.903089986991944,0.0963674839157623,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",0.34251,0.879,0.588,8,0.736,"famciclovir",0.230622673923862,0.133122185662501,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.3542,-0.898,0.58,1306,0.69,"azodicarbonamide, cyclocytidine, mitomycin.c",0.236572006437063,0.161150909262745,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.42686,1.08,0.342,76,0.658,"UH.232...., clebopride, isofloxythepin, remoxipride",0.465973893943865,0.181774106386044,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",0.70992,1.84,0.0149,228,0.259,"levonorgestrel, estradiol.cypionate, erteberel, equol",1.82681373158773,0.586700235918748,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",0.29114,0.751,0.787,420,0.826,"tamoxifen, toremifene, clomifene",0.104025267640935,0.0830199526796178,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.47648,-1.21,0.254,1378,0.57,"AZD4547, lucitanib",0.595166283380062,0.244125144327509,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",-0.28884,-0.729,0.772,1055,0.853,"sunitinib, pacritinib, ponatinib, tozasertib, KW.2449, sorafenib",0.112382699664264,0.069050968832477,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",0.39257,1.04,0.395,454,0.662,"rimexolone, hydrocortisone, triamcinolone.acetonide, dexamethasone.acetate, piretanide, methylprednisolone, deflazacort, prednisolone, betamethasone, desonide, prednisolone.acetate, clobetasol.propionate, fluocinolone.acetonide",0.40340290437354,0.1791420105603,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.24319,0.66,0.889,138,0.89,"diazooxonorleucine, JNJ.16259685, kynurenic.acid",0.0510982390297863,0.0506099933550872,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",-0.38873,-0.998,0.443,1238,0.64,"TWS.119, indirubin, AZD2858",0.35359627377693,0.193820026016113,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",-0.49051,-1.24,0.228,1334,0.575,"PHA.848125, AZD3463",0.642065152999546,0.24033215531037,FALSE
+"H1703","Pearson.est","HCV inhibitor",0.37486,0.984,0.435,298,0.667,"mericitabine, PSI.7976",0.361510743045363,0.175874166083451,FALSE
+"H1703","Pearson.est","HDAC inhibitor",-0.44591,-1.13,0.311,1046,0.583,"resminostat, RG2833, SB.939, M.344, JNJ.26481585, ACY.1215, mocetinostat, entinostat, scriptaid, romidepsin, PCI.24781, panobinostat, trichostatin.a, AR.42, givinostat, dacinostat",0.507239610973163,0.234331445240986,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.45108,1.2,0.251,250,0.523,"chloropyramine, cimetidine, ranitidine, epinastine, nizatidine, cyproheptadine, terfenadine, ICI.162846",0.600326278518962,0.281498311132726,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",0.37795,0.989,0.432,903,0.689,"mevastatin, pitavastatin, atorvastatin, simvastatin, fluvastatin, lovastatin",0.364516253185088,0.161780778092374,FALSE
+"H1703","Pearson.est","HSP inhibitor",-0.5752,-1.48,0.0982,1353,0.745,"VER.49009, tanespimycin, alvespimycin, ganetespib, NVP.AUY922",1.00788851221305,0.127843727251707,FALSE
+"H1703","Pearson.est","JAK inhibitor",-0.27566,-0.689,0.825,1128,0.886,"pacritinib, AZ960, AT.9283, tozasertib, PRT062070",0.0835460514500749,0.0525662781129492,FALSE
+"H1703","Pearson.est","KIT inhibitor",-0.3151,-0.806,0.709,1148,0.798,"regorafenib, vatalanib, telatinib, imatinib, KI.8751, sorafenib",0.149353764816933,0.0979971086492706,FALSE
+"H1703","Pearson.est","MDM inhibitor",0.29334,0.749,0.776,1025,0.803,"nutlin.3, AMG.232, idasanutlin, serdemetan, RITA, CGM097",0.110138278741812,0.095284454721319,FALSE
+"H1703","Pearson.est","MEK inhibitor",-0.50687,-1.28,0.213,1205,0.641,"selumetinib, arctigenin, MEK162, trametinib, PD.184352, cobimetinib, TAK.733, AZD8330, nobiletin",0.671620396561262,0.193141970481183,FALSE
+"H1703","Pearson.est","MET inhibitor",-0.32364,-0.847,0.651,1335,0.755,"LY2801653",0.186419011431808,0.122053048370812,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.39711,-1.02,0.413,950,0.642,"vinblastine, D.64131, cabazitaxel, vinflunine, podophyllotoxin",0.384049948343599,0.192464971931147,FALSE
+"H1703","Pearson.est","mTOR inhibitor",-0.60611,-1.52,0.0914,1062,0.938,"PF.04691502, WAY.600, deforolimus, PF.05212384, LY3023414, AZD8055, NVP.BEZ235, torin.2, everolimus, GDC.0980, WYE.354, temsirolimus, torin.1, OSI.027, PKI.179, GSK2126458, AZD2014, XL388, SB.2343, MLN0128",1.03905380426617,0.0277971616209356,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.34838,-0.906,0.576,1402,0.696,"Ro.106.9920, bortezomib",0.239577516576788,0.157390760389438,FALSE
+"H1703","Pearson.est","opioid receptor agonist",-0.29422,-0.759,0.756,1038,0.83,"trimebutine, salvinorin.a, ADL5859",0.121478204498793,0.0809219076239261,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.45973,1.2,0.278,316,0.523,"TAK.715, SB.242235, CMPD.1",0.555955204081924,0.281498311132726,FALSE
+"H1703","Pearson.est","PARP inhibitor",-0.2416,-0.61,0.886,1272,0.95,"E7449",0.0525662781129492,0.0222763947111523,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.41536,-1.04,0.376,1146,0.629,"ponatinib, regorafenib, SU014813, vatalanib, telatinib, imatinib, KI.8751, axitinib, sorafenib, trapidil",0.424812155072339,0.201349354554731,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.38598,-1,0.424,958,0.656,"AS.1949490, bis.maltolato.oxovanadium.IV., CID.5458317, mycophenolic.acid, BVT.948",0.372634143407267,0.18309616062434,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",0.32783,0.841,0.612,153,0.771,"cilostamide, avanafil, papaverine",0.213248577854439,0.112945621949043,FALSE
+"H1703","Pearson.est","PI3K inhibitor",-0.37692,-0.953,0.499,1057,0.676,"PI3K.IN.2, PF.04691502, PF.05212384, LY3023414, NVP.BEZ235, buparlisib, TG.100713, GDC.0980, PIK.75, BGT226, PKI.179, GSK2126458, SB.2343",0.30189945437661,0.170053304058364,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.61196,-1.56,0.0575,1095,1,"BI.2536, volasertib, rigosertib, NMS.1286937, GSK461364",1.24033215531037,0,FALSE
+"H1703","Pearson.est","potassium channel blocker",0.52065,1.35,0.165,38,0.429,"oleoylethanolamide, meglitinide",0.782516055786094,0.367542707815276,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",0.60299,1.57,0.0761,494,0.285,"oleoylethanolamide, GW.501516, S26948, ciprofibrate, clofibrate",1.11861534322943,0.54515513999149,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",0.60922,1.56,0.0697,263,0.264,"levonorgestrel, norethindrone.acetate, nomegestrol.acetate, tanaproget",1.15676722190199,0.578396073130169,FALSE
+"H1703","Pearson.est","proteasome inhibitor",-0.48594,-1.26,0.208,1080,0.64,"ixazomib.citrate, ixazomib, carfilzomib, bortezomib",0.681936665037238,0.193820026016113,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.58266,-1.5,0.0836,1135,0.82,"cycloheximide, brefeldin.a, puromycin, florfenicol, anguidine, harringtonine, emetine, mercaptopurine, methacycline, thiostrepton, tedizolid.phosphate, homoharringtonine",1.07779372256098,0.0861861476162833,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.49453,-1.24,0.211,1023,0.575,"PP.121, BMS.599626, NVP.TAE226, tyrphostin.A9, AV.412, mubritinib",0.675717544702307,0.24033215531037,FALSE
+"H1703","Pearson.est","RAF inhibitor",-0.45742,-1.16,0.277,1088,0.577,"LGX818, AZ.628, regorafenib, TAK.632, CEP.32496, sorafenib",0.557520230935551,0.238824186844269,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",-0.42852,-1.09,0.33,1055,0.608,"sunitinib, regorafenib, sorafenib",0.481486060122112,0.216096420727265,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",0.56133,1.46,0.106,221,0.352,"adarotene, tamibarotene, adapalene",0.97469413473523,0.453457336521869,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.19767,-0.503,0.975,981,0.978,"clofarabine, gemcitabine, fludarabine, cladribine",0.0109953843014632,0.00966114521239857,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",0.62283,1.62,0.0509,144,0.262,"aripiprazole, NAN.190",1.29328221766324,0.581698708680255,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",0.4441,1.23,0.197,51,0.586,"aripiprazole, SB.228357",0.705533773838407,0.232102383981909,FALSE
+"H1703","Pearson.est","sodium channel blocker",0.3546,0.909,0.572,158,0.742,"oxcarbazepine, quinidine, benzethonium",0.242603971206976,0.129596094720973,FALSE
+"H1703","Pearson.est","src inhibitor",0.30378,0.798,0.686,198,0.784,"dasatinib, PP.2, saracatinib",0.163675884293248,0.105683937315562,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.53761,-1.36,0.142,1223,0.653,"sulconazole, terconazole, ketoconazole",0.847711655616944,0.185086818724926,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.55192,1.44,0.0984,246,0.344,"D.4476, LY2109761",1.00700490156866,0.46344155742847,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",-0.42487,-1.07,0.381,1217,0.618,"trifluridine, carmofur",0.419075024324381,0.209011524911184,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.45213,-1.16,0.277,1037,0.577,"valrubicin, amsacrine, teniposide, SN.38, camptothecin, daunorubicin, amonafide, nemorubicin, beta.lapachone, TAS.103",0.557520230935551,0.238824186844269,FALSE
+"H1703","Pearson.est","tubulin polymerization inhibitor",-0.42507,-1.1,0.357,997,0.613,"BNC105, vindesine, fenbendazole, podophyllotoxin, fosbretabulin, epothilone.d, nocodazole, plinabulin, flubendazole, paclitaxel, epothilone.b, dolastatin.10, albendazole, docetaxel",0.447331783887807,0.212539525481585,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",-0.3587,-0.912,0.54,1023,0.705,"PP.121, sunitinib, tyrphostin.AG.99, BMS.599626, NVP.TAE226, tyrphostin.A9, regorafenib, AV.412, AMG.208, sorafenib, mubritinib",0.267606240177031,0.151810883008601,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",-0.38476,-0.986,0.458,1105,0.641,"foretinib, tivozanib, regorafenib, SU014813, vatalanib, telatinib, KI.8751, axitinib, sorafenib, lucitanib, ZM.306416",0.339134521996131,0.193141970481183,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.34282,0.895,0.531,954,0.737,"doxercalciferol, ercalcitriol, calcitriol, alfacalcidol, tacalcitol, paricalcitol, maxacalcitol",0.274905478918531,0.132532512140949,FALSE
+"H1299","Pearson.est","EGFR inhibitor",-0.1354,-0.316,1,1241,1,"CUDC.101, ARRY.334543, BIBU.1361, AST.1306",0,0,FALSE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.36687,-0.856,0.675,972,0.925,"ZM.306416, flumatinib, nilotinib, bafetinib, imatinib, tozasertib, KW.2449",0.170696227168975,0.0338582672609674,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.57095,-1.35,0.106,928,0.526,"oxiracetam, xanomeline, nefiracetam, pilocarpine",0.97469413473523,0.279014255846261,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",0.58807,1.69,0.0442,600,0.171,"darifenacin, hyoscyamine, dicycloverine, iododexetimide, methscopolamine, diphemanil",1.35457773065091,0.767003889607846,TRUE
+"H1299","Pearson.est","adenosine receptor antagonist",-0.38832,-0.915,0.603,799,0.879,"SCH.58261, istradefylline, MRS.1220, CGS.15943, PSB.1115",0.219682687859849,0.0560111249262281,FALSE
+"H1299","Pearson.est","adrenergic receptor agonist",0.28751,0.849,0.615,1036,0.736,"lidamidine, terbutaline, ritodrine, oxymetazoline, xylazine, epinephrine, isoetharine, isoxsuprine, A61603, metaraminol, methyldopa, norepinephrine, buphenine, clenbuterol, midodrine",0.211124884224583,0.133122185662501,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",-0.20531,-0.488,0.987,861,1,"propranolol, idazoxan, dihydroergocristine, carvedilol, naftidrofuryl, atipamezole, oxprenolol",0.00568284733036327,0,FALSE
+"H1299","Pearson.est","AKT inhibitor",-0.4995,-1.18,0.261,856,0.764,"CCT128930, palomid.529, MK.2206, AZD5363, ONC201, triciribine, A.674563, uprosertib",0.583359492661719,0.11690664142431,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.16532,-0.393,0.997,968,1,"CEP.37440, AZD3463, DMH1",0.00130484168834428,0,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",0.61026,1.83,0.0373,568,0.139,"RU.58841, bicalutamide, nilutamide, flutamide, cyproterone.acetate, enzalutamide",1.42829116819131,0.856985199745905,TRUE
+"H1299","Pearson.est","antioxidant",-0.44115,-1.03,0.436,753,0.836,"chlorogenic.acid, benfotiamine, trolox, taurine",0.360513510731414,0.0777937225609836,FALSE
+"H1299","Pearson.est","AP inhibitor",0.45452,1.31,0.13,51,0.468,"birinapant, GDC.0152",0.886056647693163,0.329754146925876,FALSE
+"H1299","Pearson.est","ATPase inhibitor",0.28202,0.851,0.586,5,0.795,"k.strophanthidin, ouabain",0.232102383981909,0.0996328713435297,FALSE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.63714,-1.49,0.0409,1048,0.355,"CYC116, PF.03814735, barasertib, PHA.680632, GSK1070916, alisertib, tozasertib, danusertib, MK.8745, AMG900, KW.2449, ENMD.2076, barasertib.HQPA, AT.9283, SNS.314, hesperadin, CCT137690, ZM.447439",1.38827669199266,0.449771646944906,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44904,-1.06,0.395,749,0.779,"josamycin, tedizolid, radezolid, azalomycin.b, valnemulin",0.40340290437354,0.108462542327436,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.34918,1.04,0.4,238,0.725,"sparfloxacin, sarafloxacin, trovafloxacin, lomefloxacin, novobiocin",0.397940008672038,0.139661993429006,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.46518,-1.08,0.346,914,0.824,"ABT.737, obatoclax, venetoclax, gossypol, TW.37",0.460923901207223,0.0840727883028842,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.34818,-0.807,0.771,1069,0.94,"flumatinib, nilotinib, bafetinib, imatinib, tozasertib",0.112945621949043,0.0268721464003014,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.24226,0.693,0.845,160,0.852,"gamma.aminobutyric.acid, eprinomectin, CL.218872, temazepam",0.0731432910503077,0.0695604052332999,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",-0.9362,-2.2,0,1350,0,"I.BET.762, bromosporine, JQ1...., PFI.1, I.BET151, OTX015",Inf,Inf,TRUE
+"H1299","Pearson.est","calcium channel blocker",-0.43836,-1.02,0.446,852,0.839,"fendiline, penfluridol, mibefradil, tetrandrine, SR.33805, carboxyamidotriazole",0.350665141287858,0.0762380391712997,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.47216,-1.12,0.309,782,0.766,"PF.04136309, RS.504393, MK.0812, navarixin, ZK811752, SB.225002",0.510041520575165,0.115771230367396,FALSE
+"H1299","Pearson.est","CDK inhibitor",-0.74249,-1.76,0.00558,1218,0.119,"indirubin, BMS.265246, indisulam, arcyriaflavin.a, JNJ.7706621, PHA.793887, alvocidib, BMS.387032, AT.7519, AZD5438, kenpaullone, P276.00, TG.02, ribociclib, abemaciclib, palbociclib, dinaciclib",2.25336580106242,0.924453038607469,TRUE
+"H1299","Pearson.est","CHK inhibitor",0.30143,0.912,0.593,125,0.823,"SCH.900776, CHIR.124",0.226945306635737,0.0846001647877302,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",-0.19078,-0.454,0.99,979,1,"tryptanthrin, piroxicam, ramifenazone, ketoprofen, FR.122047, aspirin",0.00436480540245009,0,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",0.34293,0.948,0.451,184,0.833,"eplerenone, morin, metyrapone",0.345823458122039,0.0793549985932124,FALSE
+"H1299","Pearson.est","DNA alkylating agent",-0.47884,-1.13,0.304,1033,0.824,"cyclophosphamide, TH.302, melphalan, estramustine, streptozotocin, mitomycin.c",0.517126416391246,0.0840727883028842,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.42701,-0.994,0.474,1062,0.798,"valrubicin, mechlorethamine, melphalan, teroxirone, pibenzimol, oxaliplatin, primaquine",0.324221658325915,0.0979971086492706,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",-0.51029,-1.2,0.236,958,0.768,"decitabine, SGI.1027, azacitidine, fdcyd",0.627087997029893,0.114638779968488,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",-0.50446,-1.18,0.247,1162,0.764,"cephalomannine, trifluridine, idoxuridine",0.607303046740334,0.11690664142431,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",-0.42814,-0.996,0.495,1119,0.834,"floxuridine, anisomycin, cyclocytidine, mitomycin.c",0.305394801066431,0.0788339493622613,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",-0.40914,-0.954,0.549,969,0.851,"oxiperomide, acetophenazine, paliperidone, lurasidone, thioproperazine, UH.232...., raclopride, sertindole",0.260427655549908,0.0700704399154121,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",0.29861,0.874,0.647,1018,0.825,"estradiol.cypionate, levonorgestrel, ethinyl.estradiol, equol, PPT, erteberel, estradiol, estrone",0.1890957193313,0.0835460514500749,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.41381,-0.971,0.507,667,0.833,"toremifene, fulvestrant, danazol, raloxifene, clomifene",0.294992040666664,0.0793549985932124,FALSE
+"H1299","Pearson.est","FGFR inhibitor",-0.52777,-1.24,0.172,1373,0.713,"lucitanib, regorafenib",0.764471553092451,0.146910470148134,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.684,-1.6,0.0168,1279,0.209,"tozasertib, GTP.14564, lestaurtinib, TG.02, KW.2449, ENMD.2076, pacritinib, sorafenib",1.77469071827414,0.679853713888946,TRUE
+"H1299","Pearson.est","glucocorticoid receptor agonist",-0.36562,-0.871,0.644,653,0.932,"halcinonide, prednisolone.hemisuccinate, methylprednisolone, difluprednate, dexamethasone.acetate, fluticasone.propionate, ciclesonide, triamcinolone, flumethasone, halobetasol.propionate, betamethasone, fludroxycortide, deflazacort, prednisolone, rimexolone, flumethasone.pivalate",0.191114132640188,0.0305840876460186,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.38767,1.18,0.248,31,0.525,"CGP.37849, latrepirdine, JNJ.16259685",0.605548319173784,0.279840696594043,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.37663,-0.891,0.611,1003,0.91,"AZD2858, GSK.3.inhibitor.IX, indirubin, kenpaullone",0.213958789757446,0.0409586076789064,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",-0.72519,-1.71,0.00797,1045,0.145,"PHA.848125, GSK1904529A, AZD3463, GW.441756, lestaurtinib, GSK1838705A, danusertib",2.09854167860389,0.838631997765025,TRUE
+"H1299","Pearson.est","HCV inhibitor",-0.43708,-1.01,0.457,1109,0.82,"mericitabine, narlaprevir",0.34008379993015,0.0861861476162833,FALSE
+"H1299","Pearson.est","HDAC inhibitor",-0.57867,-1.37,0.108,1150,0.548,"AR.42, entinostat, ACY.1215, PCI.24781, R306465, RG2833, givinostat, SB.939, belinostat, scriptaid, resminostat, vorinostat, dacinostat, trichostatin.a, M.344",0.96657624451305,0.261219441515631,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",-0.2599,-0.613,0.94,635,1,"chloropyramine, epinastine, ebastine, famotidine, lafutidine, pheniramine, cyproheptadine, BF2.649, astemizole, levocetirizine, terfenadine, tiotidine",0.0268721464003014,0,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",0.83548,2.61,0,209,0,"simvastatin, pitavastatin, fluvastatin, atorvastatin, lovastatin",Inf,Inf,TRUE
+"H1299","Pearson.est","HSP inhibitor",-0.42578,-0.995,0.492,895,0.816,"NMS.E973, SNX.5422, NVP.AUY922, PU.H71, alvespimycin, XL888, tanespimycin",0.30803489723264,0.0883098412461389,FALSE
+"H1299","Pearson.est","JAK inhibitor",-0.45317,-1.06,0.395,905,0.779,"LY2784544, WHI.P154, TG.101348, TG.101209, PRT062070, AZ960, atiprimod, tozasertib, lestaurtinib, TG.02, AT.9283, pacritinib",0.40340290437354,0.108462542327436,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.48019,-1.12,0.306,1208,0.766,"imatinib, KI.8751, pazopanib, regorafenib, OSI.930, sorafenib",0.51427857351842,0.115771230367396,FALSE
+"H1299","Pearson.est","MDM inhibitor",-0.54903,-1.29,0.143,843,0.628,"idasanutlin, RITA, CGM097, nutlin.3, serdemetan",0.844663962534938,0.202040356262804,FALSE
+"H1299","Pearson.est","MEK inhibitor",-0.48424,-1.12,0.308,825,0.766,"BIX.02188, nobiletin, Ro.4987655, PD.198306, selumetinib, PD.184352, refametinib, cobimetinib, trametinib, PD.318088, AZD8330, arctigenin, PD.98059, TAK.733, PD.0325901, MEK162",0.511449283499556,0.115771230367396,FALSE
+"H1299","Pearson.est","MET inhibitor",-0.36365,-0.853,0.685,1227,0.912,"AMG458",0.164309428507574,0.0400051616715838,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.5908,-1.4,0.0763,1175,0.557,"colchicine, cabazitaxel, vinflunine, podophyllotoxin, D.64131",1.11747546204512,0.254144804826271,FALSE
+"H1299","Pearson.est","mTOR inhibitor",-0.29231,-0.683,0.877,1144,1,"WYE.125132, GSK2126458, AZD8055, AZD2014, LY303511, XL388",0.0570004066339595,0,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.53389,-1.27,0.162,1029,0.658,"tyloxapol, bortezomib, IKK.2.inhibitor.V, Ro.106.9920, betulinic.acid, parthenolide...., EVP4593",0.790484985457369,0.181774106386044,FALSE
+"H1299","Pearson.est","opioid receptor agonist",0.28777,0.824,0.654,123,0.721,"BW.180C, spiradoline",0.184422251675733,0.142064735280571,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",-0.48789,-1.14,0.296,955,0.825,"SB.242235, skepinone.l, SB.239063, talmapimod",0.528708288941061,0.0835460514500749,FALSE
+"H1299","Pearson.est","PARP inhibitor",-0.46651,-1.08,0.378,717,0.824,"AZD2461, AG.14361, E7449, PJ.34, olaparib, niraparib, talazoparib",0.422508200162775,0.0840727883028842,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.33325,-0.783,0.78,967,0.944,"SU014813, vatalanib, axitinib, crenolanib, trapidil, imatinib, KI.8751, pazopanib, regorafenib, sorafenib",0.10790539730952,0.025028005701931,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.32763,-0.771,0.777,1242,0.945,"GSK2830371, CID.5458317",0.109578981199086,0.0245681914907371,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",-0.36128,-0.843,0.712,1063,0.913,"papaverine, trequinsin",0.147520006363144,0.039529222465701,FALSE
+"H1299","Pearson.est","PI3K inhibitor",-0.22402,-0.524,0.973,1160,1,"GSK2126458, CUDC.907, LY303511, PIK.75",0.0118871597316481,0,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.7703,-1.8,0.00228,1110,0.117,"NMS.1286937, HMN.214, volasertib, rigosertib, GSK461364, BI.2536, GW.843682X",2.64206515299955,0.931814138253838,TRUE
+"H1299","Pearson.est","potassium channel blocker",0.42711,1.26,0.179,84,0.466,"ibutilide, dofetilide, mepivacaine",0.747146969020107,0.33161408331,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",-0.26789,-0.619,0.928,930,1,"ciprofibrate, oleoylethanolamide, GW.501516",0.0324520237811379,0,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.36785,-0.864,0.682,838,0.928,"danazol, tanaproget, norethindrone, dienogest, melengestrol.acetate",0.166215625343521,0.0324520237811379,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.3152,-0.739,0.824,540,0.97,"delanzomib, MG.132, carfilzomib, ixazomib.citrate, bortezomib, ixazomib",0.0840727883028842,0.0132282657337552,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.43532,-1.01,0.464,769,0.82,"methacycline, azomycin..2.nitroimidazole., cycloheximide, puromycin, emetine, brefeldin.a, tedizolid.phosphate, mercaptopurine, harringtonine, thiostrepton, homoharringtonine, anguidine, bruceantin",0.333482019445119,0.0861861476162833,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.56209,-1.32,0.136,1297,0.576,"mubritinib, tyrphostin.A9, NVP.TAE226",0.866461091629782,0.239577516576788,FALSE
+"H1299","Pearson.est","RAF inhibitor",-0.67795,-1.6,0.0246,1180,0.209,"SB.590885, AZ.628, GDC.0879, PLX.4720, CEP.32496, regorafenib, RAF265, TAK.632, sorafenib",1.60906489289662,0.679853713888946,TRUE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.66807,-1.57,0.029,1398,0.229,"regorafenib, sorafenib",1.53760200210104,0.640164517660112,TRUE
+"H1299","Pearson.est","retinoid receptor agonist",-0.21554,-0.509,0.984,600,1,"adapalene, fenretinide, tamibarotene, adarotene, bexarotene",0.00700490156865849,0,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.3336,-0.785,0.776,1037,0.958,"fludarabine, clofarabine, cladribine",0.110138278741812,0.0186344909214556,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",-0.68558,-1.6,0.0191,1264,0.209,"zolmitriptan, aripiprazole",1.71896663275227,0.679853713888946,TRUE
+"H1299","Pearson.est","serotonin receptor antagonist",-0.52057,-1.21,0.233,1027,0.776,"paliperidone, lurasidone, SB.228357, SB.216641, sertindole, aripiprazole",0.632644078973981,0.110138278741812,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.39093,-0.921,0.578,890,0.885,"brivaracetam, quinidine, A.803467, triamterene, lappaconite, ajmaline, benzethonium",0.238072161579471,0.0530567293021746,FALSE
+"H1299","Pearson.est","src inhibitor",0.45082,1.35,0.18,11,0.507,"dasatinib, saracatinib",0.744727494896694,0.294992040666664,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.40245,-0.942,0.578,1200,0.859,"chlormidazole",0.238072161579471,0.0660068361687577,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",-0.29435,-0.681,0.885,1080,1,"SB.525334, D.4476",0.0530567293021746,0,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",-0.59114,-1.39,0.0844,1251,0.536,"carmofur, trifluridine, raltitrexed",1.07365755337434,0.27083521030723,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.49371,-1.17,0.265,872,0.762,"rubitecan, dexrazoxane, doxorubicin, irinotecan, teniposide, licochalcone.a, camptothecin, daunorubicin, idarubicin, valrubicin, SN.38, amonafide, etoposide, genz.644282, voreloxin, exatecan.mesylate, beta.lapachone, TAS.103",0.576754126063192,0.1180450286604,FALSE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.58691,-1.35,0.105,1127,0.526,"vindesine, paclitaxel, dolastatin.10, parbendazole, combretastatin.A.4, docetaxel, ABT.751, plinabulin, vincristine, podophyllotoxin, flubendazole, vinorelbine, KX2.391, CYT.997, albendazole, nocodazole, taltobulin, fosbretabulin",0.978810700930062,0.279014255846261,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",-0.4499,-1.06,0.406,1132,0.779,"aminopurvalanol.a, bafetinib, tivantinib, GTP.14564, mubritinib, tyrphostin.A9, UNC2250, NVP.TAE226, regorafenib, sorafenib",0.391473966422806,0.108462542327436,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.46131,-1.07,0.364,1268,0.826,"KI.8751, pazopanib, golvatinib, lucitanib, regorafenib, ENMD.2076, RAF265, OSI.930, sorafenib",0.438898616350944,0.0830199526796178,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",-0.34947,-0.814,0.75,845,0.946,"ercalcitriol, doxercalciferol, tacalcitol",0.1249387366083,0.0241088635982073,FALSE
diff --git a/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_venn_diagram.pdf b/Examples/cell_corr/Fig6 - Coldren met/DMEA/DMEA_venn_diagram.pdf
new file mode 100644
index 0000000..e413884
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diff --git a/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_correlation_matrix.pdf b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_correlation_matrix.pdf
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index 0000000..0031c2a
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diff --git a/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_dot_plot.pdf b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_dot_plot.pdf
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index 0000000..d9eb977
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diff --git a/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_interactive_network.graph.html b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_interactive_network.graph.html
new file mode 100644
index 0000000..65ecc90
--- /dev/null
+++ b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_interactive_network.graph.html	
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNFQxNDozODo1NyswMTowMDwveG1wOk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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-b979552dadd29ae6aff3" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_mean_results.csv
new file mode 100644
index 0000000..202eb0d
--- /dev/null
+++ b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_mean_results.csv	
@@ -0,0 +1,3 @@
+"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"alpha amino acids",0.0387499999999999,1.14799573055322,0.189915440401228,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"CALU3, H520",0.189915440401228
+"acyl carnitines",-0.22335,1.33176603267596,0.00112427633817813,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H2126, HCC2279, H460",0.00224855267635625
diff --git a/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..afb5bf8
--- /dev/null
+++ b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_results.csv	
@@ -0,0 +1,41 @@
+"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H358","Input","alpha amino acids",-0.28972,-1.03,0.4,62,0.39,"sarcosine, homocysteine, glycine, citrulline, dimethylglycine, creatinine, betaine, acetylglycine, ornithine, phosphocreatine, creatine",0.397940008672038,0.408935392973501,FALSE
+"H358","Input","acyl carnitines",-0.38991,-1.41,0.133,85,0.254,"propionylcarnitine, heptanoylcarnitine, stearoylcarnitine, malonylcarnitine, hexanoylcarnitine, palmitoylcarnitine, myristoylcarnitine",0.876148359032914,0.595166283380062,FALSE
+"H1650","Input","alpha amino acids",-0.41638,-1.5,0.0821,173,0.076,"glycine, creatinine, betaine, ornithine, dimethylglycine, creatine, citrulline",1.08565684288056,1.11918640771921,FALSE
+"H1650","Input","acyl carnitines",0.36239,1.3,0.167,146,0.173,"hexanoylcarnitine, myristoylcarnitine, heptanoylcarnitine, malonylcarnitine, palmitoylcarnitine, stearoylcarnitine, propionylcarnitine",0.777283528852417,0.761953896871205,FALSE
+"HCC95","Input","alpha amino acids",-0.26711,-0.937,0.505,79,0.509,"homocysteine, creatine, glycine, citrulline, creatinine, dimethylglycine, betaine, sarcosine, acetylglycine, ornithine",0.296708621881339,0.293282217663241,FALSE
+"HCC95","Input","acyl carnitines",-0.38991,-1.37,0.138,85,0.248,"stearoylcarnitine, propionylcarnitine, palmitoylcarnitine, myristoylcarnitine, malonylcarnitine, heptanoylcarnitine, hexanoylcarnitine",0.860120913598763,0.605548319173784,FALSE
+"H3255","Input","alpha amino acids",0.33475,1.14,0.31,115,0.3,"homocysteine, creatine, acetylglycine, sarcosine, glycine, citrulline, dimethylglycine, creatinine, betaine",0.508638306165727,0.522878745280338,FALSE
+"H3255","Input","acyl carnitines",-0.35088,-1.26,0.185,179,0.195,"propionylcarnitine, myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.732828271596986,0.709965388637482,FALSE
+"H1648","Input","alpha amino acids",0.21893,0.77,0.736,40,0.739,"phosphocreatine, creatine, creatinine, glycine",0.133122185662501,0.131355561605174,FALSE
+"H1648","Input","acyl carnitines",0.25529,0.885,0.59,13,1,"palmitoylcarnitine, myristoylcarnitine",0.229147988357856,0,FALSE
+"H1975","Input","alpha amino acids",0.30803,1.07,0.368,39,0.365,"homocysteine, creatinine, dimethylglycine, phosphocreatine, ornithine",0.434152181326482,0.437707135543525,FALSE
+"H1975","Input","acyl carnitines",-0.41428,-1.44,0.0909,125,0.0932,"heptanoylcarnitine, hexanoylcarnitine, malonylcarnitine, stearoylcarnitine, myristoylcarnitine, palmitoylcarnitine",1.04143611677803,1.03058408764602,FALSE
+"HCC78","Input","alpha amino acids",-0.28078,-1,0.435,103,0.891,"phosphocreatine, citrulline, dimethylglycine, creatinine, homocysteine, betaine, creatine, ornithine, acetylglycine",0.361510743045363,0.0501222959631252,FALSE
+"HCC78","Input","acyl carnitines",-0.27409,-0.976,0.471,126,0.474,"hexanoylcarnitine, myristoylcarnitine, palmitoylcarnitine, stearoylcarnitine, heptanoylcarnitine",0.326979092871104,0.324221658325915,FALSE
+"H2126","Input","alpha amino acids",-0.28519,-1.01,0.415,104,0.417,"betaine, phosphocreatine, homocysteine, sarcosine, creatine, creatinine, dimethylglycine, citrulline, ornithine",0.381951903287907,0.379863945026242,FALSE
+"H2126","Input","acyl carnitines",-0.50072,-1.79,0.0204,178,0.0494,"heptanoylcarnitine, myristoylcarnitine, propionylcarnitine, palmitoylcarnitine, stearoylcarnitine",1.6903698325741,1.30627305107635,TRUE
+"HCC827","Input","alpha amino acids",0.26472,0.941,0.498,149,0.51,"ornithine, phosphocreatine, sarcosine, dimethylglycine, creatinine, glycine, creatine, homocysteine, betaine, citrulline",0.302770657240282,0.292429823902064,FALSE
+"HCC827","Input","acyl carnitines",-0.15596,-0.563,0.929,34,0.945,"malonylcarnitine, heptanoylcarnitine, propionylcarnitine, hexanoylcarnitine, myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.0319842860063582,0.0245681914907371,FALSE
+"CALU3","Input","alpha amino acids",-0.44662,-1.61,0.0475,163,0.0506,"sarcosine, creatine, dimethylglycine, betaine, citrulline, creatinine, glycine, phosphocreatine",1.32330639037513,1.2958494831602,TRUE
+"CALU3","Input","acyl carnitines",0.34173,1.17,0.256,62,0.263,"palmitoylcarnitine, myristoylcarnitine, hexanoylcarnitine, stearoylcarnitine",0.59176003468815,0.580044251510242,FALSE
+"H2009","Input","alpha amino acids",-0.30219,-1.05,0.403,150,0.795,"betaine, ornithine, creatinine, citrulline, sarcosine, dimethylglycine, homocysteine",0.39469495385889,0.0996328713435297,FALSE
+"H2009","Input","acyl carnitines",-0.23817,-0.843,0.622,87,0.637,"stearoylcarnitine, palmitoylcarnitine, heptanoylcarnitine, myristoylcarnitine, propionylcarnitine, hexanoylcarnitine",0.206209615309181,0.19586056766465,FALSE
+"HCC4006","Input","alpha amino acids",0.24766,0.856,0.594,172,0.592,"sarcosine, glycine, betaine, creatine, acetylglycine, ornithine, phosphocreatine, creatinine, homocysteine, citrulline, dimethylglycine",0.226213555018806,0.22767829327708,FALSE
+"HCC4006","Input","acyl carnitines",-0.30744,-1.12,0.282,100,0.3,"stearoylcarnitine, hexanoylcarnitine, propionylcarnitine, malonylcarnitine, palmitoylcarnitine, heptanoylcarnitine",0.549750891680639,0.522878745280338,FALSE
+"HCC2279","Input","alpha amino acids",-0.23263,-0.847,0.609,136,0.63,"betaine, creatinine, acetylglycine, glycine, creatine, sarcosine, phosphocreatine",0.215382707367125,0.200659450546418,FALSE
+"HCC2279","Input","acyl carnitines",0.55124,1.88,0.0146,75,0.0143,"stearoylcarnitine, palmitoylcarnitine, myristoylcarnitine, propionylcarnitine, malonylcarnitine, hexanoylcarnitine",1.83564714421556,1.84466396253494,TRUE
+"H520","Input","alpha amino acids",0.55543,1.96,0.00916,69,0.0145,"homocysteine, phosphocreatine, sarcosine, betaine, creatinine, ornithine, dimethylglycine, creatine, glycine",2.03810452633215,1.83863199776503,TRUE
+"H520","Input","acyl carnitines",0.37677,1.34,0.16,115,0.152,"hexanoylcarnitine, malonylcarnitine, myristoylcarnitine, propionylcarnitine, heptanoylcarnitine, palmitoylcarnitine",0.795880017344075,0.818156412055227,FALSE
+"HCC15","Input","alpha amino acids",-0.19164,-0.689,0.825,64,0.828,"ornithine, creatinine, dimethylglycine, acetylglycine, sarcosine, betaine, citrulline, glycine, creatine, phosphocreatine",0.0835460514500749,0.0819696632151199,FALSE
+"HCC15","Input","acyl carnitines",0.37551,1.32,0.156,112,0.161,"myristoylcarnitine, palmitoylcarnitine, hexanoylcarnitine, stearoylcarnitine, malonylcarnitine, propionylcarnitine",0.806875401645538,0.79317412396815,FALSE
+"H460","Input","alpha amino acids",0.33725,1.17,0.255,134,0.271,"homocysteine, phosphocreatine, sarcosine, creatine, dimethylglycine, creatinine, citrulline, ornithine, glycine, betaine",0.593459819566045,0.567030709125594,FALSE
+"H460","Input","acyl carnitines",-0.46083,-1.68,0.0486,208,0.0435,"myristoylcarnitine, heptanoylcarnitine, palmitoylcarnitine, stearoylcarnitine",1.31336373073771,1.36151074304536,TRUE
+"A549","Input","alpha amino acids",0.14945,0.524,0.976,74,0.977,"ornithine, glycine, citrulline, sarcosine, homocysteine",0.0105501823333082,0.0101054362812269,FALSE
+"A549","Input","acyl carnitines",0.42635,1.51,0.0624,39,0.148,"propionylcarnitine, malonylcarnitine, hexanoylcarnitine, stearoylcarnitine",1.20481541031758,0.829738284605043,FALSE
+"HCC44","Input","alpha amino acids",0.44653,1.57,0.0694,111,0.0644,"homocysteine, phosphocreatine, creatinine, sarcosine, dimethylglycine, ornithine, creatine, glycine, betaine, citrulline",1.15864052954514,1.19111413264019,FALSE
+"HCC44","Input","acyl carnitines",-0.26991,-0.97,0.465,192,0.455,"myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.332547047110046,0.341988603342888,FALSE
+"H1703","Input","alpha amino acids",-0.16231,-0.573,0.942,182,0.943,"dimethylglycine, ornithine, betaine, sarcosine",0.0259490972071227,0.0254883072626717,FALSE
+"H1703","Input","acyl carnitines",0.32084,1.13,0.302,124,0.296,"propionylcarnitine, hexanoylcarnitine, palmitoylcarnitine, myristoylcarnitine, malonylcarnitine, stearoylcarnitine",0.519993057042849,0.528708288941061,FALSE
+"H1299","Input","alpha amino acids",0.29166,1.02,0.425,143,0.425,"homocysteine, sarcosine, citrulline, phosphocreatine, glycine, ornithine, creatinine, dimethylglycine, acetylglycine, betaine",0.371611069949688,0.371611069949688,FALSE
+"H1299","Input","acyl carnitines",-0.44634,-1.58,0.0767,200,0.0613,"myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine, heptanoylcarnitine",1.11520463605102,1.21253952548158,FALSE
diff --git a/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_venn_diagram.pdf b/Examples/cell_corr/Fig6 - Coldren met/GSEA/GSEA_venn_diagram.pdf
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diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_correlation_matrix.pdf b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_correlation_matrix.pdf
new file mode 100644
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diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_dot_plot.pdf b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_dot_plot.pdf
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diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_interactive_network.graph.html b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
index 0000000..defcaa3
--- /dev/null
+++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-d94b61fa6026a3b95427" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..ab877c7
--- /dev/null
+++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_mean_results.csv
@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"cytochrome P450 inhibitor",0.876666666666667,1.00088672806879,0.0086732059516819,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC95, H460",0.0479917395993065
+"acetylcholine receptor agonist",0.84,0.981875200364542,0.0187649104580172,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, H1648",0.0819730298955488
+"p38 MAPK inhibitor",0.838083333333333,0.864376334110147,0.103470892747094,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265858053738951
+"NFkB pathway inhibitor",0.7805,0.794129082706332,0.317938570821485,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.57367176909094
+"FGFR inhibitor",0.674416666666667,1.21420317742156,0.00447307638995378,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, HCC44",0.030938778363847
+"serotonin receptor antagonist",0.651166666666667,1.08345120570864,0.0627786803196693,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.19298631357528
+"RET tyrosine kinase inhibitor",0.644416666666667,1.11701025130262,0.0364862884683016,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.137652815584956
+"benzodiazepine receptor agonist",0.6175,0.685363805182726,0.912639505388095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"TGF beta receptor inhibitor",0.525916666666667,1.25066109487839,0.00662065423596996,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.0412925122398183
+"opioid receptor agonist",0.521583333333333,1.0187109910732,0.304889601260715,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.563896132065115
+"HMGCR inhibitor",0.471833333333333,1.68930549652988,8.88527761264178e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"HCC95, H1648, H520, H460, H1703",0.000737478041849268
+"sodium channel blocker",0.466166666666667,0.74089943291716,0.979145061559025,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098
+"PPAR receptor agonist",0.387333333333333,1.34340221644581,0.00283885002824505,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, H460",0.0214204138494854
+"ALK tyrosine kinase receptor inhibitor",0.38225,1.06331404109981,0.387162880759495,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.642690382060762
+"ATPase inhibitor",0.349083333333333,1.20677183640965,0.0779912864289485,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.231188456200097
+"PARP inhibitor",0.3195,1.13556837991138,0.184433352021348,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.43167357234584
+"glycogen synthase kinase inhibitor",0.303333333333333,0.982268833164354,0.718799968916346,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.956759865623637
+"KIT inhibitor",0.297583333333333,1.14045879590256,0.223209326253665,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.443410599485832
+"proteasome inhibitor",0.296916666666667,1.18114993724016,0.104955152106426,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265858053738951
+"calcium channel blocker",0.292666666666667,0.914596317640971,0.916338688797989,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"FLT3 inhibitor",0.281,0.964007544293376,0.827608248971204,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"phosphatase inhibitor",0.276833333333333,0.989890153073317,0.726215319690231,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.956759865623637
+"PDGFR tyrosine kinase receptor inhibitor",0.263916666666667,1.01934350159425,0.675381696632086,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.91896198066333
+"RAF inhibitor",0.244916666666667,1.07575406604208,0.479705052937464,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.7239185344329
+"VEGFR inhibitor",0.243,0.897066127085198,0.946713880873679,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098
+"bacterial 50S ribosomal subunit inhibitor",0.235,0.95884172549251,0.851644962674686,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"DNA polymerase inhibitor",0.229666666666667,1.15197130119976,0.222608692235743,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.443410599485832
+"AKT inhibitor",0.22725,1.15322930976848,0.22437644793259,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.443410599485832
+"protein synthesis inhibitor",0.210083333333333,0.935316714306232,0.90728584620874,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"cyclooxygenase inhibitor",0.193833333333333,0.837323748980083,0.989425338225455,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098
+"HSP inhibitor",0.17025,1.21147229173282,0.0937937724513926,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.261017984411138
+"dopamine receptor antagonist",0.1645,1.01882994387948,0.767483539159279,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"bromodomain inhibitor",0.163666666666667,1.34796947182408,0.0104162808386764,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0540344568506337
+"potassium channel blocker",0.1605,1.21880429482789,0.0587742306504205,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.187625428614804
+"HCV inhibitor",0.158916666666667,1.11659192988253,0.386980173562551,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.642690382060762
+"histamine receptor antagonist",0.136083333333333,0.979566180263055,0.855720482560209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"serotonin receptor agonist",0.133,1.71516795419898,2.90588505535249e-05,"H1650, H1975, H1648, H2126, H520, H1299, HCC44, A549, H1703, HCC15",10,4,"H1650, H1975, H2126, HCC44",0.000803961531980855
+"tyrosine kinase inhibitor",0.126833333333333,0.894017676592922,0.97026185028203,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098
+"bacterial DNA gyrase inhibitor",0.12475,1.29372078798817,0.0407587584228695,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.139569248430214
+"glutamate receptor antagonist",0.115333333333333,0.977015988827328,0.856698747435749,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"microtubule inhibitor",0.113083333333333,1.13815380477918,0.327576205805222,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.578485640039008
+"DNA methyltransferase inhibitor",0.0930833333333334,1.1808025359,0.192432797310796,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.43167357234584
+"progesterone receptor agonist",0.0768333333333334,1.00142224618365,0.794727251766373,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"estrogen receptor antagonist",0.0765,1.51789312715176,0.00181298275223466,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, HCC44, H1703",0.0188096960544346
+"phosphodiesterase inhibitor",0.0733333333333333,1.08045851658479,0.526231556470045,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.766267003280943
+"adrenergic receptor agonist",0.0403333333333333,1.11064971430185,0.452472905326071,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.71196056736095
+"sterol demethylase inhibitor",0.0378333333333332,1.42738201762612,0.00222006383011884,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0204739219888738
+"CC chemokine receptor antagonist",0.03075,1.15781056112585,0.30572681858952,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.563896132065115
+"AP inhibitor",0.01375,1.10037845762265,0.454625422531691,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.71196056736095
+"growth factor receptor inhibitor",-0.0294166666666667,1.20072897996731,0.189910624691489,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.43167357234584
+"androgen receptor antagonist",-0.0505833333333333,1.32105209162541,0.0250627317145587,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.104010336615418
+"glucocorticoid receptor agonist",-0.0795,1.10852641744878,0.286352904065215,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.552727698544485
+"tubulin polymerization inhibitor",-0.0880833333333334,1.35971463973701,0.00696500206454767,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0412925122398183
+"BCL inhibitor",-0.110916666666667,0.97000397921708,0.876326884665977,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"JAK inhibitor",-0.120583333333333,0.938358378749663,0.922335846036889,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"Aurora kinase inhibitor",-0.12675,1.15973164019644,0.201954317472493,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.441110746058341
+"MEK inhibitor",-0.12775,1.52971085354538,0.000602854834447704,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H520, H1299, HCC44",0.00833949187652658
+"adrenergic receptor antagonist",-0.154666666666667,0.82305300098125,0.995101540024098,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098
+"adenosine receptor antagonist",-0.161583333333333,1.38589553970337,0.0383476448878849,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, H1299",0.138384979378019
+"Bcr.Abl kinase inhibitor",-0.185333333333333,1.17267994031801,0.216024891854153,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.443410599485832
+"Abl kinase inhibitor",-0.194666666666667,1.05996452199061,0.553529871258227,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.792120333007463
+"antioxidant",-0.205166666666667,1.18668268205059,0.15175071691499,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.37045027952777
+"HDAC inhibitor",-0.2235,1.10553166970796,0.3602338127518,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.622904301216653
+"ribonucleotide reductase inhibitor",-0.230083333333333,1.40655701227781,0.00270008486262209,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H1299, H1703",0.0214204138494854
+"retinoid receptor agonist",-0.246166666666667,1.07782321314206,0.430192750540294,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.700117613624399
+"CDK inhibitor",-0.25725,1.27355387686298,0.0340165253075869,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.134446266691891
+"acetylcholine receptor antagonist",-0.258833333333333,1.41661143920871,0.00087757273138874,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, H460",0.0104055052436093
+"DNA inhibitor",-0.28025,0.875908580223468,0.962925550187264,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995101540024098
+"DNA synthesis inhibitor",-0.287166666666667,1.03828764917254,0.589188937900493,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.828859014334592
+"MET inhibitor",-0.299833333333333,1.2458488039984,0.617762537095821,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC95, H1975",0.854571509649219
+"protein tyrosine kinase inhibitor",-0.322166666666667,1.1781454481386,0.105702599679342,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265858053738951
+"topoisomerase inhibitor",-0.33525,1.43605198215613,0.000157945690400697,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H1299, H1703",0.00314867287279141
+"PLK inhibitor",-0.3605,1.80454040988532,0.000189679088722374,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"H1650, H1648, H2126, H520, H460, H1299, H1703",0.00314867287279141
+"MDM inhibitor",-0.389583333333333,1.52233704656142,2.74910526086175e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H520, A549",0.000803961531980855
+"src inhibitor",-0.397583333333333,0.927751579047022,0.787468623596433,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"DNA alkylating agent",-0.40425,0.888010557369674,0.825690852330219,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"PI3K inhibitor",-0.44475,0.842401558856366,0.905941820867927,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.994206171702101
+"EGFR inhibitor",-0.480416666666667,1.22737980032361,0.0127257599189964,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0586798929598168
+"vitamin D receptor agonist",-0.520166666666667,1.25996001620061,0.011320851593563,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0552723930744548
+"estrogen receptor agonist",-0.546416666666667,0.951931095513778,0.46501032655729,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.714738094523242
+"CHK inhibitor",-0.58625,1.14392022329913,0.0420389302500645,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.139569248430214
+"thymidylate synthase inhibitor",-0.607416666666667,0.900989401444408,0.500947081242813,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.742475138270598
+"mTOR inhibitor",-0.6845,0.988909362516468,0.0943438497871585,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, A549",0.261017984411138
diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..022f2b5
--- /dev/null
+++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_results.csv
@@ -0,0 +1,995 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H1650","Pearson.est","EGFR inhibitor",-0.69499,-1.87,0.0124,1196,0.547,"ARRY.334543, BIBU.1361, AST.1306, WZ.4002, CNX.2006, WZ.3146, TAK.285, gefitinib, GW.583340, XL.647, neratinib, PD.168393, WZ8040, vandetanib, PD.153035, lapatinib, BMS.690514, AZD8931, AEE788, BMS.599626, pelitinib, dacomitinib, canertinib, osimertinib, afatinib, poziotinib, erlotinib, icotinib",1.90657831483776,0.262012673666569,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",0.34763,0.875,0.588,519,0.814,"tozasertib, KW.2449, flumatinib, bafetinib, GZD824, imatinib",0.230622673923862,0.0893755951107988,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.7087,1.73,0.0188,399,0.157,"xanomeline, oxiracetam, nefiracetam, tremorine, pilocarpine",1.72584215073632,0.804100347590766,TRUE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.6503,-1.74,0.0312,1235,0.401,"iododexetimide, darifenacin",1.50584540598156,0.396855627379818,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",-0.5796,-1.52,0.105,1335,0.454,"MRS.1220, CGS.15943",0.978810700930062,0.342944147142896,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.3338,-0.877,0.579,1109,0.715,"A61603, isoxsuprine, methyldopa, ritodrine, xylazine, isoetharine",0.237321436272564,0.145693958198919,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",-0.23368,-0.648,0.881,1277,0.924,"metoprolol, prazosin, practolol",0.0550240915879521,0.0343280287798933,FALSE
+"H1650","Pearson.est","AKT inhibitor",0.40596,1.02,0.416,100,0.676,"uprosertib, GDC.0068",0.380906669373257,0.170053304058364,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.40275,-1.11,0.313,1301,0.782,"lorlatinib, AZD3463, AP26113",0.504455662453552,0.106793246940152,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.60305,-1.6,0.0876,1174,0.467,"bicalutamide, enzalutamide, RU.58841, flutamide",1.05749589383192,0.330683119433888,FALSE
+"H1650","Pearson.est","antioxidant",-0.51703,-1.39,0.12,1434,0.558,"rutin",0.920818753952375,0.253365801062421,FALSE
+"H1650","Pearson.est","AP inhibitor",-0.38175,-0.988,0.446,1309,0.78,"tanshinone.i, birinapant",0.350665141287858,0.10790539730952,FALSE
+"H1650","Pearson.est","ATPase inhibitor",0.55822,1.39,0.114,245,0.522,"k.strophanthidin, evodiamine, ouabain, digitoxin, NMS.873",0.943095148663527,0.282329496997738,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.68046,1.72,0.0185,385,0.126,"PHA.680632, danusertib, AMG900, barasertib, CCT137690, tozasertib, MK.8745, SNS.314, GSK1070916, barasertib.HQPA, MK.5108, KW.2449, alisertib, AT.9283, CCT129202, hesperadin, PF.03814735, ENMD.2076",1.73282827159699,0.899629454882437,TRUE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.31141,0.783,0.73,353,0.897,"valnemulin, azithromycin, tilmicosin",0.136677139879544,0.0472075569559079,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.40901,-1.05,0.393,1300,0.73,"sarafloxacin, lomefloxacin",0.405607449624573,0.136677139879544,FALSE
+"H1650","Pearson.est","BCL inhibitor",0.48413,1.24,0.213,304,0.6,"venetoclax, navitoclax, gossypol",0.671620396561262,0.221848749616356,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.3598,0.892,0.566,519,0.807,"tozasertib, flumatinib, bafetinib, GZD824, imatinib",0.247183568811729,0.0931264652779296,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",0.28805,0.73,0.791,150,0.864,"ZK.93423, nefiracetam",0.101823516502323,0.0634862575211067,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.7214,1.81,0.0146,319,0.136,"I.BET.762, bromosporine, JQ1...., I.BET151, PFI.1",1.83564714421556,0.866461091629782,TRUE
+"H1650","Pearson.est","calcium channel blocker",-0.34088,-0.921,0.505,1296,0.744,"SR.33805, tetrandrine, mibefradil",0.296708621881339,0.128427064454121,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",-0.36072,-0.93,0.51,1106,0.758,"MK.0812, RS.504393, navarixin, ZK811752",0.292429823902064,0.120330794367946,FALSE
+"H1650","Pearson.est","CDK inhibitor",0.56939,1.41,0.121,247,0.523,"indisulam, PHA.793887, JNJ.7706621, alvocidib, PHA.848125, AT.7519, ribociclib, R547, dinaciclib, aminopurvalanol.a, palbociclib, abemaciclib",0.91721462968355,0.281498311132726,FALSE
+"H1650","Pearson.est","CHK inhibitor",-0.53348,-1.44,0.115,984,0.532,"LY2603618, LY2606368, SCH.900776, AZD7762, CHIR.124",0.939302159646388,0.274088367704952,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",-0.33401,-0.889,0.559,1373,0.72,"metoxibutropate, FR.122047, FK.3311, naproxen",0.252588192113577,0.142667503568732,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",-0.40919,-1.12,0.319,1261,0.815,"clotrimazole, metyrapone",0.496209316942819,0.0888423912600234,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.48766,1.23,0.218,376,0.586,"estramustine, carmustine, mitomycin.c, carboplatin, satraplatin, melphalan",0.661543506395395,0.232102383981909,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.405,1.03,0.423,424,0.683,"carmustine, oxaliplatin, chlorambucil, carboplatin, pibenzimol, bendamustine, melphalan, mechlorethamine, valrubicin",0.373659632624958,0.165579296318467,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.62668,1.61,0.0335,329,0.217,"decitabine, disulfiram, SGI.1027, fdcyd",1.47495519296315,0.66354026615147,TRUE
+"H1650","Pearson.est","DNA polymerase inhibitor",-0.30496,-0.823,0.633,1271,0.753,"cidofovir, menadione",0.198596289982645,0.123205023799299,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",-0.35013,-0.954,0.483,1167,0.745,"enocitabine, artemisinin, CB.10.277, estramustine.phosphate",0.316052869248488,0.127843727251707,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",-0.33122,-0.894,0.545,1284,0.737,"nemonapride, clebopride, piperacetazine, remoxipride",0.263603497723358,0.132532512140949,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",-0.4736,-1.23,0.192,1159,0.695,"levonorgestrel, estradiol, estradiol.cypionate",0.71669877129645,0.158015195409886,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",-0.50094,-1.35,0.143,890,0.567,"toremifene, danazol, clomifene, raloxifene, fulvestrant",0.844663962534938,0.246416941107093,FALSE
+"H1650","Pearson.est","FGFR inhibitor",0.31472,0.788,0.742,324,0.914,"dovitinib, regorafenib, nintedanib",0.129596094720973,0.0390538042661686,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.44308,1.11,0.345,439,0.637,"sorafenib, dovitinib, tozasertib, TG.101348, KW.2449, tandutinib, tyrphostin.AG.1296, ENMD.2076, sunitinib",0.462180904926726,0.19586056766465,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",0.27445,0.694,0.812,168,0.889,"hydrocortisone, prednisolone.hemisuccinate, fluorometholone, fluticasone.propionate, beclomethasone.dipropionate",0.0904439707588247,0.0510982390297863,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",-0.42851,-1.16,0.241,1371,0.781,"MTPG, SIB.1757, CGP.37849",0.617982957425132,0.1073489661227,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.36414,0.92,0.547,924,0.834,"CHIR.99021, kenpaullone, AZD2858, indirubin, TWS.119, GSK.3.inhibitor.IX, CHIR.98014, tideglusib, LY2090314",0.262012673666569,0.0788339493622613,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.49613,1.27,0.201,210,0.614,"danusertib, PHA.848125, GSK1838705A",0.696803942579511,0.211831628858832,FALSE
+"H1650","Pearson.est","HCV inhibitor",-0.36027,-0.976,0.448,1427,0.768,"PSI.7976",0.348721986001856,0.114638779968488,FALSE
+"H1650","Pearson.est","HDAC inhibitor",-0.19221,-0.511,0.98,1345,0.976,"mocetinostat, romidepsin, JNJ.26481585",0.00877392430750515,0.0105501823333082,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",-0.39816,-1.08,0.36,1084,0.712,"nizatidine, ranitidine, cimetidine, lafutidine, BF2.649, tecastemizole, famotidine, astemizole, chloropyramine",0.443697499232713,0.147520006363144,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.58846,-1.59,0.0576,1099,0.407,"lovastatin, simvastatin, fluvastatin, pitavastatin",1.23957751657679,0.39040559077478,FALSE
+"H1650","Pearson.est","HSP inhibitor",0.5087,1.28,0.174,432,0.682,"SNX.2112, NVP.AUY922, ganetespib, XL888, tanespimycin, SNX.5422, BIIB021, NMS.E973, PU.H71, alvespimycin",0.7594507517174,0.166215625343521,FALSE
+"H1650","Pearson.est","JAK inhibitor",0.30266,0.771,0.717,291,0.892,"AZD1480, tozasertib, TG.101348, AZ960, AT.9283",0.1444808443322,0.0496351456238769,FALSE
+"H1650","Pearson.est","KIT inhibitor",0.37336,0.917,0.542,463,0.812,"sorafenib, OSI.930, KI.8751, tandutinib, regorafenib, cediranib, sunitinib, masitinib",0.266000713461613,0.0904439707588247,FALSE
+"H1650","Pearson.est","MDM inhibitor",-0.37143,-0.968,0.449,1316,0.75,"serdemetan, RITA",0.347753658996677,0.1249387366083,FALSE
+"H1650","Pearson.est","MEK inhibitor",0.44378,1.11,0.339,248,0.637,"PD.0325901, cobimetinib, refametinib, trametinib, Ro.4987655, AS.703026",0.469800301796918,0.19586056766465,FALSE
+"H1650","Pearson.est","MET inhibitor",-0.39804,-1.08,0.334,1424,0.712,"PF.04217903",0.476253533188435,0.147520006363144,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.488,1.24,0.219,126,0.6,"vinflunine, D.64131, cabazitaxel, vinblastine",0.659555885159882,0.221848749616356,FALSE
+"H1650","Pearson.est","mTOR inhibitor",-0.48457,-1.27,0.201,1165,0.67,"everolimus, temsirolimus, LY3023414, PKI.179, torin.2, PF.05212384, GSK2126458, PI.103, WAY.600, deforolimus, SB.2343, sirolimus",0.696803942579511,0.173925197299174,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",0.31241,0.77,0.732,420,0.87,"bortezomib, parthenolide, curcumin, parthenolide...., EVP4593, BAY.11.7082",0.135488918941608,0.0604807473813815,FALSE
+"H1650","Pearson.est","opioid receptor agonist",0.44695,1.1,0.346,474,0.63,"trimebutine, salvinorin.a, spiradoline, ADL5859",0.460923901207223,0.200659450546418,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.49107,1.22,0.24,91,0.574,"skepinone.l, talmapimod",0.619788758288394,0.241088107602027,FALSE
+"H1650","Pearson.est","PARP inhibitor",0.7127,1.81,0.0153,282,0.136,"niraparib, talazoparib, olaparib, PJ.34, endo.IWR.1",1.8153085691824,0.866461091629782,TRUE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.4571,1.14,0.316,463,0.633,"sorafenib, axitinib, crenolanib, dovitinib, KI.8751, CP.673451, tandutinib, regorafenib, nintedanib, trapidil, sunitinib, SU014813, masitinib",0.500312917381596,0.198596289982645,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",-0.37351,-1,0.423,1244,0.795,"BVT.948, menadione, mycophenolate.mofetil, bis.maltolato.oxovanadium.IV.",0.373659632624958,0.0996328713435297,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",-0.27408,-0.725,0.791,1200,0.879,"cilostamide, GSK256066, EMD.53998",0.101823516502323,0.0560111249262281,FALSE
+"H1650","Pearson.est","PI3K inhibitor",-0.25728,-0.685,0.826,1195,0.906,"LY3023414, PI3K.IN.2, PKI.179, idelalisib, PF.05212384, GSK2126458, PI.103, SB.2343",0.0830199526796178,0.0428718023231869,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.9121,2.33,0,85,0,"GW.843682X, volasertib, NMS.1286937, rigosertib, HMN.214, BI.2536",Inf,Inf,TRUE
+"H1650","Pearson.est","potassium channel blocker",-0.30929,-0.836,0.613,1430,0.758,"ibutilide",0.212539525481585,0.120330794367946,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",-0.66674,-1.77,0.0224,1291,0.5,"S26948, clofibrate, fenofibrate, GW.501516",1.64975198166584,0.301029995663981,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",-0.22784,-0.605,0.899,1159,0.943,"levonorgestrel, norethindrone.acetate",0.0462403082667712,0.0254883072626717,FALSE
+"H1650","Pearson.est","proteasome inhibitor",0.51224,1.29,0.191,405,0.714,"bortezomib, ixazomib, carfilzomib, MG.132",0.718966632752272,0.146301788223826,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.41741,1.05,0.389,292,0.672,"harringtonine, tedizolid.phosphate, anguidine, cycloheximide, bruceantin, homoharringtonine, puromycin",0.410050398674292,0.172630726946175,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.35833,0.908,0.566,16,0.803,"PP.121",0.247183568811729,0.095284454721319,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.46645,1.15,0.273,554,0.644,"sorafenib, SB.590885, dabrafenib, regorafenib, TAK.632, GDC.0879, AZ.628, vemurafenib",0.563837352959244,0.191114132640188,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.42025,1.05,0.393,290,0.672,"sorafenib, cabozantinib, regorafenib",0.405607449624573,0.172630726946175,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.19188,0.485,0.989,223,1,"tamibarotene",0.0048037084028206,0,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.33652,0.844,0.659,363,0.845,"cytarabine, pentostatin, cladribine, fludarabine",0.18111458540599,0.0731432910503077,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",0.73148,1.84,0.00969,93,0.215,"aripiprazole, pardoprunox, zolmitriptan",2.01367622294923,0.667561540084395,TRUE
+"H1650","Pearson.est","serotonin receptor antagonist",0.6872,1.72,0.0294,386,0.126,"aripiprazole, SB.200646, paliperidone, lurasidone, pirenperone, SB.216641, ziprasidone, sertindole",1.53165266958784,0.899629454882437,TRUE
+"H1650","Pearson.est","sodium channel blocker",0.2338,0.593,0.931,429,0.969,"brivaracetam, mexiletine, benzocaine, mepivacaine",0.0310503190186574,0.0136762229492347,FALSE
+"H1650","Pearson.est","src inhibitor",-0.34202,-0.898,0.556,1051,0.757,"bosutinib, PP.2, ZM.306416, dasatinib, saracatinib, PP.1",0.254925208417942,0.120904120499927,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",0.19198,0.481,0.978,475,0.985,"chlormidazole, lanoconazole",0.00966114521239857,0.00656376950238827,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.40915,-1.1,0.337,590,0.755,"SB.431542, LY2109761, repsox, SB.525334, adaprev, D.4476",0.472370099128661,0.122053048370812,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.48768,1.2,0.263,579,0.579,"carmofur, trifluridine, capecitabine, raltitrexed",0.580044251510242,0.237321436272564,FALSE
+"H1650","Pearson.est","topoisomerase inhibitor",0.51288,1.27,0.202,359,0.614,"topotecan, nemorubicin, dexrazoxane, SN.38, daunorubicin, etoposide.phosphate, idarubicin, TAS.103, exatecan.mesylate, amsacrine, rubitecan, genz.644282, amonafide",0.694648630553376,0.211831628858832,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.7108,1.77,0.0237,321,0.146,"docetaxel, verubulin, vindesine, fosbretabulin, paclitaxel, fenbendazole, KX2.391, epothilone.b, taltobulin, albendazole, BNC105, dolastatin.10, oxibendazole, vinblastine, plinabulin, ABT.751, vincristine, CYT.997, combretastatin.A.4, parbendazole, indibulin",1.6252516539899,0.835647144215563,TRUE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.30262,0.755,0.749,25,0.87,"sorafenib, PP.121, tivantinib",0.125518182300534,0.0604807473813815,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.29552,0.737,0.771,447,0.875,"sorafenib, OSI.930, axitinib, dovitinib, KI.8751, semaxanib, cabozantinib, regorafenib, nintedanib, cediranib, tivozanib, ENMD.2076, sunitinib, golvatinib, SU014813",0.112945621949043,0.0579919469776868,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.64135,-1.72,0.0354,1225,0.333,"calcitriol, paricalcitol",1.45099673797421,0.47755576649368,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",-0.7411,-1.89,0.00798,1158,0.433,"PD.168393, FERb.033, salvianolic.acid.B, brigatinib, ARRY.334543, WZ.4002, pelitinib, BIBX.1382, AEE788, rociletinib, BIBU.1361, BMS.599626, poziotinib, WZ8040, icotinib, WZ.3146, BMS.690514, AZD8931, CNX.2006, erlotinib, dacomitinib, neratinib, osimertinib, canertinib, CUDC.101, afatinib, tucatinib, gefitinib, XL.647, CP.724714, lapatinib",2.09799710864927,0.363512103646635,FALSE
+"HCC95","Pearson.est","Abl kinase inhibitor",0.27185,0.672,0.864,102,0.935,"KW.2449, GZD824",0.0634862575211067,0.0291883891274822,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.63397,1.56,0.0514,395,0.432,"tremorine, xanomeline, nefiracetam, oxiracetam",1.28903688100472,0.364516253185088,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.42401,-1.11,0.322,1327,0.718,"dicycloverine, diphemanil",0.492144128304169,0.1438755557577,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",-0.49374,-1.28,0.205,1367,0.989,"PSB.1115, CGS.15943",0.688246138944246,0.0048037084028206,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",0.29311,0.723,0.78,167,0.991,"isoxsuprine, xylazine, ritodrine",0.10790539730952,0.00392634551472468,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",-0.26514,-0.705,0.83,1363,0.858,"dihydroergocristine, atenolol......, practolol",0.0809219076239261,0.0665127121512946,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.37794,-0.982,0.412,1061,0.678,"triciribine, GSK2110183, A.674563, AT7867, GDC.0068, uprosertib",0.385102783966865,0.168770306132937,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.46196,-1.26,0.191,1027,0.925,"SB.505124, alectinib, NVP.TAE684, brigatinib, CEP.37440, AZD3463",0.718966632752272,0.0338582672609674,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",0.42804,1.05,0.386,164,0.789,"flutamide",0.413412695328245,0.10292299679058,FALSE
+"HCC95","Pearson.est","antioxidant",0.58078,1.45,0.0847,500,0.496,"benfotiamine, trolox, taurine, mesna, chlorogenic.acid",1.07211658966929,0.304518323509803,FALSE
+"HCC95","Pearson.est","AP inhibitor",0.35959,0.859,0.616,24,0.954,"idronoxil",0.210419287835575,0.0204516252959049,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",0.27935,0.705,0.801,9,0.991,"k.strophanthidin",0.0963674839157623,0.00392634551472468,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",0.2807,0.7,0.821,406,0.972,"KW.2449, ZM.447439, SNS.314, aurora.a.inhibitor.i, MK.5108, AMG900, AT.9283, PF.03814735, CYC116",0.0856568428805592,0.0123337350737254,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.4049,1.01,0.444,344,0.804,"tilmicosin, josamycin, dirithromycin",0.35261702988538,0.0947439512515487,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.5687,1.41,0.109,373,0.484,"nadifloxacin, finafloxacin, norfloxacin, trovafloxacin, sparfloxacin",0.962573502059376,0.315154638355588,FALSE
+"HCC95","Pearson.est","BCL inhibitor",-0.27778,-0.729,0.786,1240,0.877,"venetoclax, obatoclax",0.104577453960592,0.0570004066339595,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.32214,-0.834,0.655,1246,0.763,"dasatinib, metatinib, imatinib",0.183758700008217,0.11747546204512,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",0.24587,0.608,0.916,172,0.936,"CGS.20625, indiplon",0.0381045263321496,0.0287241512618947,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",0.5426,1.34,0.152,18,0.545,"PFI.1",0.818156412055227,0.263603497723358,FALSE
+"HCC95","Pearson.est","calcium channel blocker",-0.39858,-1.08,0.354,1296,0.623,"mibefradil, tetrandrine, penfluridol",0.450996737974212,0.20551195334083,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",0.46241,1.13,0.32,143,0.687,"MK.0812, UNBS.5162",0.494850021680094,0.16304326294045,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.47113,-1.23,0.24,1067,0.81,"CR8..R., BMS.265246, aminopurvalanol.a, AZD5438, AT.7519, alvocidib, JNJ.7706621, PHA.793887, ribociclib, palbociclib, dinaciclib, arcyriaflavin.a, BMS.387032",0.619788758288394,0.0915149811213502,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.62405,-1.61,0.051,1089,0.688,"LY2603618, AZD7762, LY2606368, SCH.900776, PF.477736",1.29242982390206,0.162411561764489,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",0.45775,1.15,0.276,128,0.678,"AM.404, suxibuzone, ketoprofen, metoxibutropate, phenylbutazone, naproxen",0.559090917934782,0.168770306132937,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.74196,1.79,0.00984,178,0.188,"eplerenone, cobicistat, metyrapone",2.00700490156866,0.72584215073632,TRUE
+"HCC95","Pearson.est","DNA alkylating agent",-0.40951,-1.09,0.334,1356,0.675,"mitomycin.c, dacarbazine",0.476253533188435,0.170696227168975,FALSE
+"HCC95","Pearson.est","DNA inhibitor",-0.21899,-0.577,0.93,1443,0.943,"mechlorethamine",0.0315170514460649,0.0254883072626717,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.31133,-0.837,0.636,1093,0.814,"disulfiram, SGI.1027, azacitidine",0.196542884351586,0.0893755951107988,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",-0.31115,-0.812,0.633,1379,0.775,"cidofovir",0.198596289982645,0.11069829749369,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",0.35427,0.869,0.617,199,0.967,"nelarabine, artesunate, CB.10.277, estramustine.phosphate",0.209714835966758,0.0145735259169983,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",0.32475,0.806,0.712,253,0.966,"paliperidone, nemonapride, raclopride, clebopride",0.147520006363144,0.0150228735845067,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.41475,-1.11,0.341,1351,0.718,"equol, levonorgestrel",0.467245621007502,0.1438755557577,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",0.51015,1.26,0.202,261,0.593,"fulvestrant, raloxifene, toremifene, danazol",0.694648630553376,0.226945306635737,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",0.34086,0.847,0.633,4,0.919,"MK.2461",0.198596289982645,0.0366844886138887,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",0.32962,0.805,0.685,52,0.94,"KW.2449, gilteritinib",0.164309428507574,0.0268721464003014,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.38943,-1.03,0.386,1087,0.62,"triamcinolone.acetonide, desonide, dexamethasone.acetate, betamethasone, halobetasol.propionate, fluorometholone, ciclesonide, beclomethasone.dipropionate, fluticasone.propionate, methylprednisolone, difluprednate, halcinonide, flumethasone.pivalate, prednisolone.acetate, flumethasone",0.413412695328245,0.207608310501746,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",0.25273,0.63,0.892,357,0.936,"JNJ.16259685, kynurenic.acid, LY456236, MTPG",0.0496351456238769,0.0287241512618947,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.51858,1.27,0.194,427,0.608,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, TWS.119",0.712198270069774,0.216096420727265,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.55716,-1.39,0.159,1203,0.806,"GW.441756, AZD3463",0.798602875679548,0.0936649581949093,FALSE
+"HCC95","Pearson.est","HCV inhibitor",0.28362,0.691,0.845,85,0.935,"mericitabine",0.0731432910503077,0.0291883891274822,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",0.34106,0.852,0.614,397,0.938,"RGFP966, R306465, entinostat, RG2833, romidepsin, nexturastat.a, panobinostat, AR.42, mocetinostat, belinostat",0.211831628858832,0.0277971616209356,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",0.36832,0.909,0.572,210,0.918,"ICI.162846, BF2.649, famotidine, epinastine, nizatidine",0.242603971206976,0.0371573187987575,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.88203,2.18,0,176,0.0055,"mevastatin, lovastatin, pitavastatin, fluvastatin, atorvastatin, simvastatin",Inf,2.25963731050576,TRUE
+"HCC95","Pearson.est","HSP inhibitor",0.70327,1.76,0.0118,240,0.177,"SNX.5422, BIIB021, ganetespib, XL888, tanespimycin, KW.2478, SNX.2112, NVP.AUY922",1.92811799269387,0.752026733638193,TRUE
+"HCC95","Pearson.est","JAK inhibitor",-0.35474,-0.913,0.536,1162,0.772,"CEP.33779, filgotinib, atiprimod, ruxolitinib, pacritinib",0.27083521030723,0.112382699664264,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.40636,-1.1,0.32,1180,0.695,"pazopanib, tandutinib, dasatinib, sunitinib, lenvatinib, imatinib",0.494850021680094,0.158015195409886,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.54328,1.34,0.173,348,0.545,"AMG.232, CGM097, serdemetan",0.761953896871205,0.263603497723358,FALSE
+"HCC95","Pearson.est","MEK inhibitor",0.30242,0.75,0.748,254,0.979,"arctigenin, PD.184352, refametinib, nobiletin",0.126098402135539,0.00921730819686218,FALSE
+"HCC95","Pearson.est","MET inhibitor",0.8132,2,0,237,0.0366,"NVP.BVU972, PHA.665752, AMG458, PF.04217903",Inf,1.43651891460559,TRUE
+"HCC95","Pearson.est","microtubule inhibitor",0.37536,0.936,0.531,199,0.928,"cytochalasin.b, secnidazole, estramustine.phosphate",0.274905478918531,0.0324520237811379,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.46661,-1.25,0.216,1066,0.846,"sirolimus, everolimus, MLN0128, PI.103, OSI.027, WAY.600, XL388, torin.1, PKI.179, PF.05212384, AZD8055, PP242, ku.0063794, WYE.354, GDC.0980, WYE.125132",0.665546248849069,0.0726296369609765,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",0.6393,1.57,0.0575,300,0.489,"BAY.11.7085, parthenolide, BAY.11.7082, tyloxapol",1.24033215531037,0.31069114087638,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",0.62423,1.52,0.0657,385,0.457,"cebranopadol, trimebutine, spiradoline, BW.180C",1.18243463044022,0.34008379993015,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",0.37627,0.924,0.534,309,0.919,"TAK.715, VX.702",0.272458742971444,0.0366844886138887,FALSE
+"HCC95","Pearson.est","PARP inhibitor",0.57243,1.42,0.116,133,0.509,"AG.14361, AZD2461",0.935542010773082,0.293282217663241,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.22836,-0.589,0.928,1180,0.961,"pazopanib, tandutinib, dasatinib, sunitinib, lenvatinib, imatinib",0.0324520237811379,0.0172766123314547,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.4852,1.2,0.248,200,0.643,"CID.5458317, BVT.948, bis.maltolato.oxovanadium.IV., GSK2830371",0.605548319173784,0.191789027075778,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.44521,1.12,0.312,405,0.675,"GSK256066, avanafil, EMD.53998, YM.976, zardaverine, anagrelide",0.505845405981557,0.170696227168975,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.42951,-1.14,0.299,1247,0.815,"PKI.179, alpelisib, PF.05212384, CH5132799, BGT226, PI3K.IN.2, taselisib, GDC.0980, idelalisib",0.52432881167557,0.0888423912600234,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.34517,-0.897,0.571,1127,0.769,"GW.843682X, volasertib, NMS.1286937",0.243363891754152,0.114073660198569,FALSE
+"HCC95","Pearson.est","potassium channel blocker",0.28284,0.695,0.809,235,0.954,"meglitinide, dofetilide",0.0920514783877277,0.0204516252959049,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.48148,1.2,0.25,448,0.643,"S26948, ciprofibrate, clofibrate, fenofibrate, pterostilbene",0.602059991327962,0.191789027075778,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",0.53383,1.32,0.175,261,0.545,"norethindrone, tanaproget, dienogest, norgestrel, danazol",0.756961951313706,0.263603497723358,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",-0.43393,-1.15,0.288,1294,0.857,"MG.132",0.540607512240769,0.0670191780768018,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",0.25974,0.649,0.863,287,0.939,"mercaptopurine, clindamycin.phosphate, azomycin..2.nitroimidazole., florfenicol, puromycin",0.0639892042847904,0.0273344077338891,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.61374,-1.59,0.0627,1314,0.56,"NVP.TAE226, BMS.599626, AV.412, CP.724714",1.20273245916928,0.2518119729938,FALSE
+"HCC95","Pearson.est","RAF inhibitor",-0.38393,-1.03,0.409,1174,0.62,"TAK.632, GDC.0879, SB.590885, CEP.32496, AZ.628",0.388276691992658,0.207608310501746,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.32061,-0.834,0.626,462,0.763,"sorafenib, apatinib, cabozantinib, vandetanib, regorafenib, sunitinib",0.20342566678957,0.11747546204512,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.42629,-1.13,0.289,1114,0.777,"bexarotene, adarotene, adapalene, tamibarotene, CD.437",0.539102157243452,0.109578981199086,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.48064,1.18,0.269,301,0.652,"clofarabine, hydroxyurea, cytarabine, fludarabine, triapine",0.570247719997592,0.18575240426808,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",0.58863,1.45,0.104,96,0.496,"tropisetron, lerisetron, paliperidone",0.98296666070122,0.304518323509803,FALSE
+"HCC95","Pearson.est","sodium channel blocker",0.1677,0.412,1,506,0.997,"oxcarbazepine, A.803467, mexiletine, mepivacaine, quinidine",0,0.00130484168834428,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.46175,-1.19,0.248,1046,0.832,"PP.2, ZM.306416, PP.1, dasatinib, saracatinib",0.605548319173784,0.0798766737092761,FALSE
+"HCC95","Pearson.est","sterol demethylase inhibitor",0.40552,1.01,0.438,92,0.804,"sulconazole",0.3585258894959,0.0947439512515487,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.54459,-1.47,0.104,922,0.728,"SB.525334, repsox, LY2109761, adaprev, SB.431542",0.98296666070122,0.137868620686963,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.33159,-0.857,0.608,1320,0.808,"carmofur",0.216096420727265,0.0925886392254138,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",0.3217,0.78,0.717,518,0.957,"nemorubicin, etoposide, beta.lapachone, camptothecin, doxorubicin, valrubicin, fleroxacin, amonafide, etoposide.phosphate, daunorubicin, rubitecan, exatecan.mesylate, teniposide",0.1444808443322,0.0190880622231565,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.39824,-1.07,0.348,841,0.61,"KX2.391, vincristine, verubulin, combretastatin.A.4, BNC105, flubendazole, epothilone.d, dolastatin.10, epothilone.b, vinorelbine, oxibendazole, mebendazole, parbendazole, ABT.751, fosbretabulin, CYT.997, plinabulin, taltobulin, fenbendazole",0.458420756053419,0.214670164989233,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.40111,-1.08,0.349,1189,0.623,"tyrphostin.A9, dasatinib, sunitinib, NVP.TAE226, BMS.599626, tivantinib, AV.412, CP.724714",0.45717457304082,0.20551195334083,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.27007,-0.705,0.815,990,0.858,"axitinib, MGCD.265, telatinib, motesanib, PD.173074, ENMD.2076, linifanib, ZM.306416, foretinib, pazopanib, SAR131675, sunitinib, AEE788, lucitanib, lenvatinib, BMS.690514, XL.647",0.0888423912600234,0.0665127121512946,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",-0.66372,-1.74,0.0367,1202,0.54,"doxercalciferol, tacalcitol, maxacalcitol",1.43533393574791,0.267606240177031,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.40412,1.06,0.369,302,0.71,"CUDC.101, neratinib, dovitinib, CP.724714, tucatinib, BMS.599626, ARRY.334543, brigatinib, lapatinib, WZ.4002, AZD8931, BMS.690514, salvianolic.acid.B, AEE788",0.43297363384094,0.148741651280925,FALSE
+"H1975","Pearson.est","Abl kinase inhibitor",-0.57883,-1.45,0.0976,1074,0.943,"GZD824, tozasertib, flumatinib, bosutinib, KW.2449",1.01055018233331,0.0254883072626717,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",0.38301,1.02,0.402,284,0.683,"oxiracetam, xanomeline, pilocarpine",0.39577394691553,0.165579296318467,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",-0.35965,-0.899,0.559,1192,0.744,"dicycloverine, iododexetimide",0.252588192113577,0.128427064454121,FALSE
+"H1975","Pearson.est","adenosine receptor antagonist",-0.38681,-0.952,0.508,1432,0.697,"theophylline",0.294136287716081,0.156767221901991,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",-0.37747,-0.953,0.483,1334,0.717,"epinephrine, A61603, norepinephrine, terbutaline",0.316052869248488,0.1444808443322,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",-0.2289,-0.571,0.934,1008,0.964,"naftidrofuryl, vincamine, idazoxan, carvedilol, atenolol...., propranolol, metoprolol",0.0296531237699066,0.0159229660971692,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.25261,0.669,0.873,1085,0.857,"A.674563, GDC.0068, GSK2110183, uprosertib, AZD5363, triciribine, AT7867, CCT128930, palomid.529, ONC201, MK.2206",0.0589857562944303,0.0670191780768018,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.3712,0.98,0.445,207,0.67,"crizotinib, brigatinib, SB.505124",0.351639989019068,0.173925197299174,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",0.32433,0.84,0.628,319,0.709,"RU.58841, enzalutamide, nilutamide",0.202040356262804,0.149353764816933,FALSE
+"H1975","Pearson.est","antioxidant",-0.48918,-1.26,0.2,1075,0.642,"chlorogenic.acid, mesna, benfotiamine",0.698970004336019,0.192464971931147,FALSE
+"H1975","Pearson.est","AP inhibitor",-0.34413,-0.857,0.61,1349,0.731,"LCL.161",0.214670164989233,0.13608262304214,FALSE
+"H1975","Pearson.est","ATPase inhibitor",0.56797,1.5,0.0943,210,0.558,"k.strophanthidin, digoxin, thonzonium",1.02548830726267,0.253365801062421,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",-0.50893,-1.26,0.212,1064,0.642,"SNS.314, tozasertib, ZM.447439, AMG900, TAK.901, AT.9283, PF.03814735, MK.8745, MLN.8054, MK.5108, GSK1070916, alisertib, CYC116, KW.2449",0.673664139071249,0.192464971931147,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26186,0.672,0.831,299,0.877,"radezolid, azithromycin",0.080398976215889,0.0570004066339595,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.56566,-1.45,0.105,1172,0.943,"sarafloxacin, finafloxacin, trovafloxacin, sparfloxacin, novobiocin",0.978810700930062,0.0254883072626717,FALSE
+"H1975","Pearson.est","BCL inhibitor",0.38889,1.02,0.415,888,0.683,"venetoclax, navitoclax, obatoclax, HA14.1, TW.37, oridonin, gossypol, ABT.737",0.381951903287907,0.165579296318467,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.53321,-1.35,0.156,946,0.87,"ponatinib, GZD824, tozasertib, flumatinib, bosutinib",0.806875401645538,0.0604807473813815,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.33446,0.873,0.565,213,0.702,"eprinomectin, ZK.93423, piperazine",0.247951552180562,0.153662887870195,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",-0.47248,-1.18,0.294,1114,0.592,"PFI.1, bromosporine, OTX015",0.531652669587843,0.22767829327708,FALSE
+"H1975","Pearson.est","calcium channel blocker",0.45927,1.19,0.261,314,0.669,"SKF.96365, efonidipine.monoethanolate, tetrandrine, SR.33805, cinnarazine",0.583359492661719,0.174573882232177,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",-0.39557,-1,0.437,1106,0.755,"RS.504393, MK.0812, navarixin",0.359518563029578,0.122053048370812,FALSE
+"H1975","Pearson.est","CDK inhibitor",0.53652,1.37,0.132,349,0.672,"R547, AT.7519, BMS.387032, indirubin, NU6027, CR8..R., indisulam, JNJ.7706621, P276.00, BMS.265246, TG.02, dinaciclib, AZD5438, PHA.848125",0.87942606879415,0.172630726946175,FALSE
+"H1975","Pearson.est","CHK inhibitor",-0.42876,-1.1,0.338,1115,0.684,"AZD7762, LY2603618, LY2606368",0.471083299722345,0.164943898279884,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.43557,-1.09,0.344,1129,0.645,"curcumin, indoprofen, FK.3311, sulfasalazine, piroxicam, acetylsalicylsalicylic.acid, metoxibutropate",0.46344155742847,0.190440285364732,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.43563,-1.09,0.355,871,0.645,"itraconazole, eplerenone, clotrimazole, cobicistat",0.449771646944906,0.190440285364732,FALSE
+"H1975","Pearson.est","DNA alkylating agent",-0.3039,-0.756,0.726,930,0.821,"melphalan, carboplatin, cisplatin, satraplatin, dianhydrogalactitol, TH.302, streptozotocin, cyclophosphamide",0.139063379299906,0.0856568428805592,FALSE
+"H1975","Pearson.est","DNA inhibitor",0.32704,0.838,0.659,304,0.692,"busulfan, mechlorethamine, nimorazole, sangivamycin, bendamustine, metronidazole",0.18111458540599,0.159893905543242,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",-0.37289,-0.953,0.495,1276,0.717,"decitabine, RG108",0.305394801066431,0.1444808443322,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",-0.34784,-0.873,0.593,1425,0.725,"cephalomannine",0.226945306635737,0.139661993429006,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",-0.43626,-1.11,0.333,912,0.694,"artesunate, capecitabine, anisomycin, cisplatin, floxuridine, CB.10.277, estramustine.phosphate, altretamine",0.47755576649368,0.158640529545145,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",-0.28285,-0.71,0.823,1263,0.864,"clebopride, UH.232...., isofloxythepin, amisulpride",0.0846001647877302,0.0634862575211067,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.54129,-1.36,0.152,1182,0.955,"PPT, estradiol, estradiol.cypionate",0.818156412055227,0.0199966284162537,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",-0.57199,-1.46,0.0968,1227,1,"raloxifene, toremifene, fulvestrant",1.01412464269161,0,FALSE
+"H1975","Pearson.est","FGFR inhibitor",0.67314,1.83,0.0179,149,0.212,"erdafitinib, lenvatinib, dovitinib, regorafenib",1.74714696902011,0.673664139071249,TRUE
+"H1975","Pearson.est","FLT3 inhibitor",0.35892,0.923,0.524,102,0.665,"sorafenib, TG.101348, dovitinib, ENMD.2076",0.280668713016273,0.177178354696895,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",0.71508,1.89,0.00649,255,0.201,"hydrocortisone, dexamethasone.acetate, triamcinolone.acetonide, difluprednate, fludroxycortide, halcinonide, desonide, rimexolone, betamethasone, ciclesonide, deflazacort, prednisolone.hemisuccinate, methylprednisolone, flumethasone, fluocinolone.acetonide",2.18775530319963,0.696803942579511,TRUE
+"H1975","Pearson.est","glutamate receptor antagonist",-0.39235,-0.989,0.473,1214,0.75,"JNJ.16259685, MTPG, LY456236, SIB.1757",0.325138859262188,0.1249387366083,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.36494,-0.912,0.571,1180,0.743,"LY2090314, AZD2858, tideglusib",0.243363891754152,0.129011186239425,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",0.37682,0.983,0.419,905,0.692,"PHA.848125, lestaurtinib, GSK1838705A, danusertib, GW.441756, GSK1904529A, AZD3463",0.377785977033705,0.159893905543242,FALSE
+"H1975","Pearson.est","HCV inhibitor",0.43528,1.15,0.294,244,0.657,"narlaprevir, embelin, daclatasvir",0.531652669587843,0.182434630440219,FALSE
+"H1975","Pearson.est","HDAC inhibitor",-0.382,-0.974,0.457,1004,0.726,"tacedinaline, givinostat, panobinostat, romidepsin, dacinostat, SB.939, M.344, entinostat, JNJ.26481585, RG2833, mocetinostat",0.34008379993015,0.139063379299906,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",-0.47536,-1.21,0.248,1105,0.566,"nizatidine, terfenadine, ebastine, lafutidine, cimetidine, pheniramine, tiotidine, BF2.649, chloropyramine",0.605548319173784,0.247183568811729,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.526,-1.31,0.195,1077,0.732,"fluvastatin, mevastatin, simvastatin, pitavastatin",0.709965388637482,0.135488918941608,FALSE
+"H1975","Pearson.est","HSP inhibitor",-0.50796,-1.29,0.178,1174,0.724,"VER.49009, ganetespib, BIIB021, NVP.AUY922, SNX.5422",0.749579997691106,0.140261433802853,FALSE
+"H1975","Pearson.est","JAK inhibitor",0.44634,1.15,0.269,393,0.657,"AZD1480, TG.101348, AZ960, ruxolitinib, TG.101209, baricitinib, TG.02, lestaurtinib, atiprimod",0.570247719997592,0.182434630440219,FALSE
+"H1975","Pearson.est","KIT inhibitor",0.35416,0.903,0.565,219,0.675,"sorafenib, lenvatinib, regorafenib, pazopanib, OSI.930",0.247951552180562,0.170696227168975,FALSE
+"H1975","Pearson.est","MDM inhibitor",-0.47526,-1.22,0.247,1347,0.577,"RITA, serdemetan",0.607303046740334,0.238824186844269,FALSE
+"H1975","Pearson.est","MEK inhibitor",-0.39755,-0.978,0.485,848,0.744,"AZD8330, PD.318088, Ro.4987655, arctigenin, selumetinib, TAK.733, PD.184352, refametinib, BIX.02188, nobiletin, PD.98059",0.314258261397736,0.128427064454121,FALSE
+"H1975","Pearson.est","MET inhibitor",-0.78956,-1.99,0,1394,0.0987,"NVP.BVU972, INC.280, PF.04217903",Inf,1.00568284733036,TRUE
+"H1975","Pearson.est","microtubule inhibitor",-0.49154,-1.24,0.224,794,0.571,"podophyllotoxin, cytochalasin.b, colchicine, D.64131, vinblastine, cabazitaxel, estramustine.phosphate",0.649751981665837,0.243363891754152,FALSE
+"H1975","Pearson.est","mTOR inhibitor",0.69481,1.78,0.0186,264,0.212,"voxtalisib, AZD8055, AZD2014, PP242, OSI.027, torin.1, XL388, WYE.354, GSK2126458, PF.05212384, LY3023414, MLN0128, WAY.600, torin.2, ku.0063794, sirolimus, deforolimus",1.73048705578208,0.673664139071249,TRUE
+"H1975","Pearson.est","NFkB pathway inhibitor",0.36622,0.967,0.444,143,0.666,"tyloxapol, EVP4593, betulinic.acid",0.35261702988538,0.176525770829699,FALSE
+"H1975","Pearson.est","opioid receptor agonist",-0.35125,-0.897,0.578,1213,0.726,"cebranopadol, spiradoline",0.238072161579471,0.139063379299906,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",0.48132,1.25,0.21,138,0.602,"SB.242235, skepinone.l, talmapimod",0.677780705266081,0.220403508742175,FALSE
+"H1975","Pearson.est","PARP inhibitor",-0.50183,-1.24,0.23,1112,0.571,"olaparib, talazoparib, E7449, niraparib",0.638272163982407,0.243363891754152,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.36497,0.929,0.528,179,0.68,"sorafenib, lenvatinib, dovitinib, regorafenib, pazopanib, crenolanib",0.277366077466188,0.167491087293764,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",-0.21472,-0.543,0.959,1342,0.959,"bis.maltolato.oxovanadium.IV.",0.0181813928293364,0.0181813928293364,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",-0.40214,-1.01,0.445,1230,0.766,"zardaverine, EMD.53998, GSK256066, trequinsin",0.351639989019068,0.115771230367396,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.51821,1.34,0.161,195,0.594,"voxtalisib, CH5132799, BGT226, alpelisib, GSK2126458, PF.05212384, LY3023414, PI3K.IN.2, CUDC.907",0.79317412396815,0.226213555018806,FALSE
+"H1975","Pearson.est","PLK inhibitor",-0.35149,-0.879,0.604,1196,0.736,"GSK461364, BI.2536",0.218963061378868,0.133122185662501,FALSE
+"H1975","Pearson.est","potassium channel blocker",0.32681,0.844,0.638,52,0.724,"ML133",0.195179321278838,0.140261433802853,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",-0.30873,-0.785,0.701,935,0.82,"oleoylethanolamide, pterostilbene, S26948, fenofibrate",0.154281982033341,0.0861861476162833,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.26309,-0.656,0.876,984,0.907,"nomegestrol.acetate, dienogest, norethindrone.acetate",0.0574958938319193,0.0423927129399047,FALSE
+"H1975","Pearson.est","proteasome inhibitor",-0.56693,-1.43,0.104,956,0.855,"ixazomib, carfilzomib, oprozomib, delanzomib, ixazomib.citrate, ONX.0914",0.98296666070122,0.0680338852718274,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.43189,1.11,0.298,325,0.693,"clofoctol, bruceantin, tedizolid.phosphate, harringtonine, methacycline, chloramphenicol.palmitate, florfenicol, cycloheximide",0.525783735923745,0.159266765388193,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.41851,1.09,0.336,151,0.691,"mubritinib, CP.724714, BMS.599626",0.473660722610156,0.160521952625802,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.52285,1.34,0.153,232,0.594,"sorafenib, regorafenib, RAF265, SB.590885",0.815308569182401,0.226213555018806,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.6027,1.6,0.0662,230,0.44,"sorafenib, regorafenib, apatinib",1.1791420105603,0.356547323513813,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.37029,0.957,0.476,94,0.657,"adarotene, fenretinide",0.322393047279507,0.182434630440219,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.52269,-1.32,0.166,1181,0.778,"triapine, LY2334737, hydroxyurea, gemcitabine, cladribine, fludarabine, clofarabine",0.779891911959945,0.109020403010311,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",0.79385,2.12,0,190,0.0508,"NAN.190, aripiprazole, zolmitriptan, pardoprunox",Inf,1.29413628771608,TRUE
+"H1975","Pearson.est","serotonin receptor antagonist",0.50867,1.37,0.161,113,0.672,"SB.200646, aripiprazole, ziprasidone, sertindole",0.79317412396815,0.172630726946175,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.32072,-0.768,0.731,872,0.824,"butamben, benzethonium, oxcarbazepine, quinidine, mepivacaine, A.803467",0.13608262304214,0.0840727883028842,FALSE
+"H1975","Pearson.est","src inhibitor",-0.50484,-1.26,0.211,1204,0.642,"masitinib, PP.2, bosutinib",0.675717544702307,0.192464971931147,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",0.39343,1,0.416,212,0.689,"posaconazole, sulconazole",0.380906669373257,0.161780778092374,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.48772,1.29,0.205,146,0.577,"adaprev, SB.525334",0.688246138944246,0.238824186844269,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",-0.48943,-1.24,0.237,1163,0.571,"raltitrexed, doxifluridine",0.625251653989896,0.243363891754152,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",-0.60478,-1.53,0.0687,987,1,"epirubicin, camptothecin, idarubicin, etoposide.phosphate, valrubicin, mitoxantrone, amsacrine, TAS.103, amonafide, teniposide, voreloxin, daunorubicin, rubitecan, licochalcone.a, etoposide, irinotecan, genz.644282, exatecan.mesylate",1.16304326294045,0,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",-0.54119,-1.34,0.149,1089,0.801,"albendazole, verubulin, fenbendazole, CYT.997, epothilone.b, paclitaxel, vinblastine, combretastatin.A.4, docetaxel, oxibendazole, parbendazole, nocodazole, epothilone.d, fosbretabulin, BNC105",0.826813731587726,0.0963674839157623,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",0.29861,0.774,0.747,151,0.765,"sorafenib, mubritinib, CP.724714, regorafenib, BMS.599626",0.126679398184601,0.116338564846382,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",0.40632,1.05,0.365,302,0.694,"sorafenib, lenvatinib, dovitinib, ENMD.2076, regorafenib, pazopanib, RAF265, OSI.930, tivozanib, nintedanib, BMS.690514, AEE788",0.437707135543525,0.158640529545145,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.48172,1.31,0.153,411,0.59,"maxacalcitol, tacalcitol, paricalcitol, alfacalcidol, ercalcitriol",0.815308569182401,0.229147988357856,FALSE
+"H1648","Pearson.est","EGFR inhibitor",-0.72943,-1.96,0.013,1297,0.32,"tucatinib, vandetanib, AST.1306, lapatinib, OSI.420, CP.724714, neratinib, PD.153035, tyrphostin.AG.1478, BIBU.1361, XL.647, BMS.690514, poziotinib, BIBX.1382, osimertinib, AZD8931, afatinib, pelitinib, canertinib, dacomitinib, erlotinib, icotinib, gefitinib, WZ8040",1.88605664769316,0.494850021680094,FALSE
+"H1648","Pearson.est","Abl kinase inhibitor",0.24575,0.622,0.912,640,0.963,"flumatinib, GZD824, nilotinib, bafetinib, metatinib, ponatinib, KW.2449, tozasertib",0.0400051616715838,0.0163737128754655,FALSE
+"H1648","Pearson.est","acetylcholine receptor agonist",0.73411,1.87,0.0104,207,0.111,"tremorine, xanomeline, oxiracetam, pilocarpine",1.98296666070122,0.954677021213343,TRUE
+"H1648","Pearson.est","acetylcholine receptor antagonist",-0.2362,-0.635,0.893,1121,0.972,"darifenacin, dicycloverine",0.0491485411114536,0.0123337350737254,FALSE
+"H1648","Pearson.est","adenosine receptor antagonist",-0.41457,-1.11,0.32,1223,0.947,"PSB.1115, MRS.1220, CGS.15943",0.494850021680094,0.0236500209967266,FALSE
+"H1648","Pearson.est","adrenergic receptor agonist",-0.55463,-1.54,0.0885,1108,1,"clenbuterol, metaraminol, A61603, oxymetazoline, isoetharine, terbutaline, lidamidine, methyldopa",1.05305672930217,0,FALSE
+"H1648","Pearson.est","adrenergic receptor antagonist",-0.24037,-0.647,0.846,1281,0.989,"atenolol......, levobunolol, dronedarone",0.0726296369609765,0.0048037084028206,FALSE
+"H1648","Pearson.est","AKT inhibitor",-0.4529,-1.21,0.23,1278,1,"CCT128930, uprosertib, triciribine",0.638272163982407,0,FALSE
+"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.26153,-0.694,0.816,1413,0.96,"GW.788388",0.0883098412461389,0.0177287669604316,FALSE
+"H1648","Pearson.est","androgen receptor antagonist",-0.55644,-1.52,0.0759,1164,1,"cyproterone.acetate, enzalutamide",1.11975822410452,0,FALSE
+"H1648","Pearson.est","antioxidant",0.51334,1.28,0.181,77,0.646,"trolox",0.742321425130815,0.189767482004916,FALSE
+"H1648","Pearson.est","AP inhibitor",0.61933,1.57,0.0598,4,0.369,"idronoxil",1.22329881601159,0.43297363384094,FALSE
+"H1648","Pearson.est","ATPase inhibitor",0.50714,1.26,0.208,559,0.647,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, digitoxin, blebbistatin...., digoxin, digitoxigenin",0.681936665037238,0.1890957193313,FALSE
+"H1648","Pearson.est","Aurora kinase inhibitor",0.3828,0.973,0.464,605,0.726,"AMG900, MK.5108, SNS.314, danusertib, CCT137690, barasertib, AT.9283, PHA.680632, hesperadin, ZM.447439, barasertib.HQPA, KW.2449, CYC116, alisertib, PF.03814735",0.333482019445119,0.139063379299906,FALSE
+"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.33047,0.817,0.666,61,0.859,"valnemulin",0.176525770829699,0.0660068361687577,FALSE
+"H1648","Pearson.est","bacterial DNA gyrase inhibitor",-0.34545,-0.93,0.515,1107,1,"sarafloxacin, finafloxacin, lomefloxacin, trovafloxacin",0.288192770958809,0,FALSE
+"H1648","Pearson.est","BCL inhibitor",-0.26478,-0.711,0.781,1092,0.999,"oridonin, HA14.1, obatoclax, venetoclax",0.1073489661227,0.000434511774017692,FALSE
+"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.30073,0.76,0.754,525,0.903,"flumatinib, GZD824, nilotinib, bafetinib, metatinib, ponatinib",0.122628654130226,0.0443122496864942,FALSE
+"H1648","Pearson.est","benzodiazepine receptor agonist",0.28356,0.714,0.81,401,0.924,"ZK.93423, piperazine, indiplon, ivermectin",0.0915149811213502,0.0343280287798933,FALSE
+"H1648","Pearson.est","bromodomain inhibitor",0.48759,1.24,0.223,208,0.579,"PFI.1, bromosporine",0.651695136951839,0.237321436272564,FALSE
+"H1648","Pearson.est","calcium channel blocker",0.32458,0.807,0.695,7,0.852,"carboxyamidotriazole",0.158015195409886,0.0695604052332999,FALSE
+"H1648","Pearson.est","CC chemokine receptor antagonist",0.43639,1.1,0.345,188,0.646,"UNBS.5162, MK.0812",0.462180904926726,0.189767482004916,FALSE
+"H1648","Pearson.est","CDK inhibitor",-0.34114,-0.939,0.516,1234,1,"BMS.387032, alvocidib, arcyriaflavin.a, P276.00, AZD5438, TG.02, indirubin",0.287350298372789,0,FALSE
+"H1648","Pearson.est","CHK inhibitor",-0.55234,-1.49,0.0797,1142,0.854,"LY2606368, CHIR.124, LY2603618, SCH.900776",1.09854167860389,0.068542129310995,FALSE
+"H1648","Pearson.est","cyclooxygenase inhibitor",0.19843,0.504,0.972,534,0.977,"phenazone, sulfasalazine, AM.404, ketoprofen, tepoxalin, suxibuzone, acetylsalicylsalicylic.acid, piroxicam, metoxibutropate, ramifenazone, curcumin",0.0123337350737254,0.0101054362812269,FALSE
+"H1648","Pearson.est","cytochrome P450 inhibitor",0.4913,1.24,0.23,178,0.579,"metyrapone, eplerenone",0.638272163982407,0.237321436272564,FALSE
+"H1648","Pearson.est","DNA alkylating agent",-0.21508,-0.581,0.927,1104,0.994,"estramustine, ifosfamide, satraplatin, cisplatin, dacarbazine",0.0329202658555029,0.00261361560268669,FALSE
+"H1648","Pearson.est","DNA inhibitor",0.37825,0.971,0.464,361,0.706,"teroxirone, valrubicin, tirapazamine, chlorambucil, bendamustine, primaquine, oxaliplatin, metronidazole",0.333482019445119,0.151195298948196,FALSE
+"H1648","Pearson.est","DNA methyltransferase inhibitor",-0.3482,-0.924,0.499,1437,0.983,"azacitidine",0.30189945437661,0.00744648216786438,FALSE
+"H1648","Pearson.est","DNA polymerase inhibitor",-0.47789,-1.31,0.16,1171,1,"cidofovir, menadione, famciclovir",0.795880017344075,0,FALSE
+"H1648","Pearson.est","DNA synthesis inhibitor",0.40811,1.02,0.425,523,0.69,"artesunate, azodicarbonamide, mitomycin.c, anisomycin, nelarabine, CB.10.277, enocitabine, artemisinin",0.371611069949688,0.161150909262745,FALSE
+"H1648","Pearson.est","dopamine receptor antagonist",-0.30482,-0.833,0.664,1163,1,"nemonapride, piperacetazine, ziprasidone, domperidone, clebopride, remoxipride, acetophenazine",0.177831920631982,0,FALSE
+"H1648","Pearson.est","estrogen receptor agonist",0.49819,1.25,0.22,265,0.629,"ethinyl.estradiol, estrone",0.657577319177794,0.201349354554731,FALSE
+"H1648","Pearson.est","estrogen receptor antagonist",0.7023,1.81,0.0162,388,0.134,"raloxifene, toremifene, fulvestrant, danazol",1.79048498545737,0.872895201635192,TRUE
+"H1648","Pearson.est","FGFR inhibitor",0.47801,1.2,0.235,259,0.594,"regorafenib, dovitinib, erdafitinib, nintedanib",0.628932137728264,0.226213555018806,FALSE
+"H1648","Pearson.est","FLT3 inhibitor",0.41601,1.06,0.374,146,0.694,"sorafenib, TG.101348, tyrphostin.AG.1296, dovitinib",0.42712839779952,0.158640529545145,FALSE
+"H1648","Pearson.est","glucocorticoid receptor agonist",0.38477,0.968,0.483,557,0.689,"deflazacort, prednisolone.hemisuccinate, fluticasone.propionate, triamcinolone, beclomethasone.dipropionate, rimexolone, prednisolone, betamethasone, ciclesonide, methylprednisolone, prednisolone.acetate, dexamethasone.acetate",0.316052869248488,0.161780778092374,FALSE
+"H1648","Pearson.est","glutamate receptor antagonist",0.24142,0.604,0.901,506,0.959,"tiletamine, MTPG, felbamate, IEM1754, LY456236, ACDPP",0.045275209020937,0.0181813928293364,FALSE
+"H1648","Pearson.est","glycogen synthase kinase inhibitor",-0.33983,-0.95,0.492,1196,1,"LY2090314, GSK.3.inhibitor.IX, indirubin",0.30803489723264,0,FALSE
+"H1648","Pearson.est","growth factor receptor inhibitor",0.53387,1.35,0.152,399,0.585,"danusertib, PHA.848125, GSK1838705A",0.818156412055227,0.23284413391782,FALSE
+"H1648","Pearson.est","HCV inhibitor",0.56934,1.45,0.0998,59,0.421,"narlaprevir, mericitabine",1.00086945871263,0.375717904164332,FALSE
+"H1648","Pearson.est","HDAC inhibitor",-0.28383,-0.764,0.715,1002,1,"pyroxamide, nexturastat.a, panobinostat, M.344, PCI.24781, SB.939, vorinostat, R306465, romidepsin, tacedinaline, JNJ.26481585",0.145693958198919,0,FALSE
+"H1648","Pearson.est","histamine receptor antagonist",-0.27547,-0.751,0.752,1447,1,"chloropyramine",0.123782159408358,0,FALSE
+"H1648","Pearson.est","HMGCR inhibitor",0.75801,1.93,0.00328,299,0.0922,"atorvastatin, pitavastatin, fluvastatin, mevastatin, lovastatin",2.48412615628832,1.03526907894637,TRUE
+"H1648","Pearson.est","HSP inhibitor",0.33178,0.839,0.648,444,0.844,"SNX.2112, NVP.AUY922, ganetespib, BIIB021, alvespimycin, tanespimycin",0.188424994129407,0.073657553374345,FALSE
+"H1648","Pearson.est","JAK inhibitor",-0.28455,-0.765,0.741,1309,1,"TG.02, atiprimod, pacritinib, CEP.33779",0.130181792020672,0,FALSE
+"H1648","Pearson.est","KIT inhibitor",0.4354,1.1,0.329,53,0.646,"sorafenib, regorafenib, masitinib",0.482804102050026,0.189767482004916,FALSE
+"H1648","Pearson.est","MDM inhibitor",0.2125,0.533,0.975,179,0.985,"AMG.232",0.0109953843014632,0.00656376950238827,FALSE
+"H1648","Pearson.est","MEK inhibitor",-0.46878,-1.27,0.177,989,1,"Ro.4987655, refametinib, PD.184352, PD.0325901, AZD8330, nobiletin, TAK.733, PD.198306, MEK162, AS.703026, cobimetinib, trametinib, selumetinib, BIX.02188",0.752026733638193,0,FALSE
+"H1648","Pearson.est","MET inhibitor",0.29442,0.732,0.763,79,0.921,"LY2801653",0.11747546204512,0.0357403698031511,FALSE
+"H1648","Pearson.est","microtubule inhibitor",0.51549,1.29,0.186,314,0.671,"D.64131, cabazitaxel, secnidazole, podophyllotoxin",0.730487055782084,0.173277479831008,FALSE
+"H1648","Pearson.est","mTOR inhibitor",-0.1587,-0.42,0.995,1138,0.997,"PI.103, temsirolimus, LY3023414, PF.05212384, PP242, GSK2126458, WAY.600",0.00217691925427455,0.00130484168834428,FALSE
+"H1648","Pearson.est","NFkB pathway inhibitor",-0.34767,-0.936,0.506,1291,1,"betulinic.acid, bindarit, IKK.2.inhibitor.V",0.295849483160201,0,FALSE
+"H1648","Pearson.est","opioid receptor agonist",0.47964,1.2,0.251,707,0.594,"trimebutine, spiradoline, salvinorin.a, ADL5859, cebranopadol",0.600326278518962,0.226213555018806,FALSE
+"H1648","Pearson.est","p38 MAPK inhibitor",-0.30726,-0.813,0.637,1009,1,"skepinone.l, TAK.715, SB.239063, CMPD.1",0.19586056766465,0,FALSE
+"H1648","Pearson.est","PARP inhibitor",0.44472,1.1,0.342,549,0.646,"AZD2461, olaparib, niraparib, talazoparib, AG.14361",0.465973893943865,0.189767482004916,FALSE
+"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.38824,0.98,0.479,295,0.737,"sorafenib, regorafenib, masitinib, dovitinib, axitinib, pazopanib, nintedanib, CP.673451",0.319664486585437,0.132532512140949,FALSE
+"H1648","Pearson.est","phosphatase inhibitor",0.26831,0.687,0.851,271,0.915,"CID.5458317, GSK2830371, bis.maltolato.oxovanadium.IV.",0.0700704399154121,0.0385789059335517,FALSE
+"H1648","Pearson.est","phosphodiesterase inhibitor",-0.28116,-0.725,0.779,1271,1,"zardaverine, cilostamide",0.108462542327436,0,FALSE
+"H1648","Pearson.est","PI3K inhibitor",-0.27111,-0.705,0.797,1138,0.974,"PI.103, CUDC.907, alpelisib, pilaralisib, LY3023414, PF.05212384, TG.100713, GSK2126458, CH5132799, idelalisib",0.0985416786038876,0.0114410431213845,FALSE
+"H1648","Pearson.est","PLK inhibitor",0.8279,2.08,0,255,0.0361,"volasertib, BI.2536, NMS.1286937, GSK461364, GW.843682X, HMN.214, rigosertib",Inf,1.44249279809434,TRUE
+"H1648","Pearson.est","potassium channel blocker",-0.31171,-0.867,0.612,1270,1,"oleoylethanolamide, ibutilide",0.213248577854439,0,FALSE
+"H1648","Pearson.est","PPAR receptor agonist",-0.43439,-1.15,0.286,1270,0.922,"oleoylethanolamide, S26948, clofibrate",0.543633966870957,0.0352690789463706,FALSE
+"H1648","Pearson.est","progesterone receptor agonist",0.46203,1.17,0.283,405,0.592,"norethindrone, nomegestrol.acetate, norgestrel, tanaproget, danazol, melengestrol.acetate",0.54821356447571,0.22767829327708,FALSE
+"H1648","Pearson.est","proteasome inhibitor",-0.2084,-0.556,0.939,1044,0.983,"carfilzomib, MG.132, ixazomib.citrate",0.0273344077338891,0.00744648216786438,FALSE
+"H1648","Pearson.est","protein synthesis inhibitor",0.46945,1.17,0.311,394,0.592,"anguidine, mercaptopurine, harringtonine, puromycin, clofoctol, homoharringtonine, cycloheximide, bruceantin, clindamycin.phosphate, thiostrepton, methacycline",0.507239610973163,0.22767829327708,FALSE
+"H1648","Pearson.est","protein tyrosine kinase inhibitor",0.40211,1.03,0.419,423,0.696,"mubritinib, PP.121, AV.412, rheochrysidin, tyrphostin.A9",0.377785977033705,0.157390760389438,FALSE
+"H1648","Pearson.est","RAF inhibitor",0.35823,0.904,0.561,34,0.778,"sorafenib, regorafenib",0.251037138743839,0.109020403010311,FALSE
+"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.58234,1.45,0.0981,34,0.421,"sorafenib, regorafenib",1.00833099262005,0.375717904164332,FALSE
+"H1648","Pearson.est","retinoid receptor agonist",-0.36845,-0.972,0.469,1407,1,"CD.437, adarotene",0.328827157284917,0,FALSE
+"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.66947,1.72,0.0185,349,0.203,"cladribine, clofarabine, pentostatin, triapine, fludarabine, fludarabine.phosphate, gemcitabine",1.73282827159699,0.692503962086787,TRUE
+"H1648","Pearson.est","serotonin receptor agonist",-0.428,-1.15,0.29,1320,0.922,"ipsapirone, aripiprazole",0.537602002101044,0.0352690789463706,FALSE
+"H1648","Pearson.est","serotonin receptor antagonist",0.34858,0.872,0.602,55,0.811,"SB.200646, paliperidone",0.220403508742175,0.090979145788844,FALSE
+"H1648","Pearson.est","sodium channel blocker",-0.29003,-0.769,0.729,1344,1,"benzethonium, lappaconite",0.137272471682025,0,FALSE
+"H1648","Pearson.est","src inhibitor",-0.33978,-0.909,0.543,1272,0.969,"PP.1, saracatinib, PP.2",0.265200170411153,0.0136762229492347,FALSE
+"H1648","Pearson.est","sterol demethylase inhibitor",0.59693,1.53,0.0713,476,0.397,"lanoconazole, chlormidazole, ketoconazole, posaconazole, sulconazole",1.14691047014813,0.401209493236885,FALSE
+"H1648","Pearson.est","TGF beta receptor inhibitor",-0.40904,-1.1,0.323,1047,0.899,"SB.431542, D.4476, repsox, LY2109761",0.490797477668897,0.0462403082667712,FALSE
+"H1648","Pearson.est","thymidylate synthase inhibitor",-0.42788,-1.16,0.269,617,1,"trifluridine, ftorafur, raltitrexed, capecitabine, carmofur, doxifluridine",0.570247719997592,0,FALSE
+"H1648","Pearson.est","topoisomerase inhibitor",0.67872,1.71,0.0327,385,0.183,"mitoxantrone, TAS.103, idarubicin, etoposide.phosphate, voreloxin, amsacrine, amonafide, nemorubicin, valrubicin, teniposide, doxorubicin, daunorubicin, SN.38, topotecan, exatecan.mesylate, epirubicin, dexrazoxane, licochalcone.a, rubitecan",1.48545224733971,0.737548910269571,TRUE
+"H1648","Pearson.est","tubulin polymerization inhibitor",0.59107,1.5,0.0746,530,0.409,"epothilone.b, docetaxel, CYT.997, dolastatin.10, mebendazole, verubulin, KX2.391, vindesine, fenbendazole, vincristine, podophyllotoxin, BNC105, taltobulin, paclitaxel, flubendazole, oxibendazole, plinabulin, combretastatin.A.4, vinblastine, ABT.751",1.12726117252733,0.388276691992658,FALSE
+"H1648","Pearson.est","tyrosine kinase inhibitor",0.41169,1.03,0.416,477,0.696,"mubritinib, sorafenib, regorafenib, hypericin, PP.121, cabozantinib, tyrphostin.AG.99, AV.412, rheochrysidin, tyrphostin.A9, aminopurvalanol.a, bafetinib",0.380906669373257,0.157390760389438,FALSE
+"H1648","Pearson.est","VEGFR inhibitor",0.27383,0.713,0.806,318,0.903,"sorafenib, regorafenib, dovitinib, foretinib, tivozanib, axitinib, pazopanib, nintedanib, TG.100572, golvatinib, cabozantinib",0.0936649581949093,0.0443122496864942,FALSE
+"H1648","Pearson.est","vitamin D receptor agonist",-0.45741,-1.22,0.237,1267,1,"maxacalcitol, paricalcitol, calcitriol",0.625251653989896,0,FALSE
+"H2126","Pearson.est","EGFR inhibitor",-0.57852,-1.44,0.104,1166,0.516,"XL.647, AEE788, OSI.420, AZD8931, poziotinib, dacomitinib, canertinib, afatinib, tucatinib, pelitinib, osimertinib, PD.168393, tyrphostin.AG.1478, neratinib, BIBX.1382, vandetanib, gefitinib, BMS.599626, AST.1306, BIBU.1361, icotinib, CP.724714, WZ8040, erlotinib, PD.153035",0.98296666070122,0.287350298372789,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",0.3849,1.01,0.431,278,0.751,"ponatinib, GZD824, flumatinib, KW.2449, nilotinib",0.365522729839268,0.124360062995832,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",0.60669,1.63,0.0694,45,0.333,"tremorine, xanomeline",1.15864052954514,0.47755576649368,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",-0.79041,-1.99,0.00337,1326,0.0748,"dicycloverine, darifenacin, diphemanil",2.47237009912866,1.12609840213554,TRUE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.70155,-1.78,0.012,1225,0.146,"istradefylline, SCH.58261, MRS.1220, CGS.15943",1.92081875395238,0.835647144215563,TRUE
+"H2126","Pearson.est","adrenergic receptor agonist",-0.46486,-1.16,0.27,1102,0.675,"oxymetazoline, xylazine, lidamidine, isoetharine, metaraminol, A61603, isoxsuprine",0.568636235841013,0.170696227168975,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",-0.30115,-0.756,0.736,1214,0.836,"pindolol, imiloxan, dronedarone",0.133122185662501,0.0777937225609836,FALSE
+"H2126","Pearson.est","AKT inhibitor",-0.31139,-0.803,0.721,841,0.843,"CCT128930, AZD5363, GSK2110183, triciribine, A.674563, palomid.529",0.142064735280571,0.0741724253752577,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.37064,0.992,0.436,66,0.756,"DMH1, alectinib",0.360513510731414,0.121478204498793,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",-0.64317,-1.59,0.0293,1081,0.332,"flutamide, enzalutamide, RU.58841, cyproterone.acetate",1.53313237964589,0.478861916295964,FALSE
+"H2126","Pearson.est","antioxidant",-0.45929,-1.16,0.28,880,0.675,"rutin, mesna, chlorogenic.acid, taurine",0.552841968657781,0.170696227168975,FALSE
+"H2126","Pearson.est","AP inhibitor",-0.45001,-1.13,0.318,1287,0.662,"tanshinone.i, birinapant",0.497572880015567,0.1791420105603,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.64458,1.76,0.0276,229,0.302,"k.strophanthidin, ouabain, oligomycin.a, digitoxigenin, omeprazole, evodiamine, NMS.873",1.55909091793478,0.519993057042849,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.30927,0.808,0.655,512,0.968,"CCT137690, KW.2449, CCT129202, AMG900, SNS.314, ENMD.2076, barasertib.HQPA, MK.5108, barasertib, aurora.a.inhibitor.i, danusertib, alisertib, MK.8745, PF.03814735, GSK1070916",0.183758700008217,0.0141246426916063,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.25069,0.667,0.838,1087,0.898,"valnemulin, josamycin, radezolid, tedizolid, tilmicosin, azithromycin, azalomycin.b, dirithromycin",0.0767559813697235,0.0467236633326956,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",-0.33767,-0.843,0.629,1305,0.831,"trovafloxacin, lomefloxacin",0.201349354554731,0.080398976215889,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.31527,0.828,0.634,147,0.995,"ABT.737, navitoclax",0.197910742118267,0.00217691925427455,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.34585,0.946,0.475,278,0.816,"ponatinib, GZD824, flumatinib, nilotinib",0.323306390375133,0.0883098412461389,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",-0.30863,-0.768,0.744,1052,0.868,"eprinomectin, CGS.20625, temazepam, gamma.aminobutyric.acid, lorazepam",0.128427064454121,0.0614802748235081,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",0.62248,1.65,0.0514,407,0.349,"PFI.1, I.BET151, bromosporine, I.BET.762",1.28903688100472,0.45717457304082,FALSE
+"H2126","Pearson.est","calcium channel blocker",-0.37128,-0.917,0.549,1400,0.846,"SKF.96365, mibefradil",0.260427655549908,0.0726296369609765,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.64532,1.73,0.0358,220,0.285,"UNBS.5162, ZK811752, SB.225002",1.44611697335613,0.54515513999149,FALSE
+"H2126","Pearson.est","CDK inhibitor",-0.43096,-1.1,0.333,1112,0.684,"JNJ.7706621, dinaciclib, alvocidib, TG.02, BMS.387032, CR8..R., arcyriaflavin.a, indirubin",0.47755576649368,0.164943898279884,FALSE
+"H2126","Pearson.est","CHK inhibitor",-0.45847,-1.14,0.301,927,0.678,"LY2606368, AZD7762, LY2603618, SCH.900776, CHIR.124",0.521433504406157,0.168770306132937,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.42495,-1.06,0.366,1320,0.694,"phenylbutazone, tryptanthrin, FK.3311, FR.122047",0.436518914605589,0.158640529545145,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",0.26856,0.705,0.827,1061,0.996,"metyrapone, cobicistat, eplerenone, PF.4981517, clotrimazole, morin, itraconazole",0.0824944904474534,0.00174066157630127,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.27125,0.729,0.787,373,1,"cyclophosphamide, dianhydrogalactitol, carmustine, temozolomide, melphalan, estramustine, mitomycin.c, carboplatin",0.104025267640935,0,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.2601,0.697,0.834,316,0.928,"chlorambucil, carmustine, teroxirone, oxaliplatin, valrubicin, melphalan",0.0788339493622613,0.0324520237811379,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",0.38344,1.01,0.432,327,0.751,"decitabine, RG108, disulfiram",0.364516253185088,0.124360062995832,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",0.18331,0.474,0.984,226,0.989,"trifluridine, adefovir.dipivoxil",0.00700490156865849,0.0048037084028206,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",-0.40562,-1.03,0.404,1418,0.719,"estramustine.phosphate, altretamine",0.393618634889395,0.143271109617117,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.42764,-1.08,0.369,1070,0.689,"sertindole, domperidone, amisulpride, UH.232...., acetophenazine, nemonapride, clebopride, remoxipride, piperacetazine",0.43297363384094,0.161780778092374,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",0.34073,0.907,0.553,88,0.864,"ethinyl.estradiol",0.257274868695302,0.0634862575211067,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",0.25867,0.699,0.816,1075,0.976,"toremifene, raloxifene, tamoxifen, danazol, clomifene, fulvestrant",0.0883098412461389,0.0105501823333082,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.48641,1.3,0.18,207,0.556,"erdafitinib, regorafenib, dovitinib, nintedanib",0.744727494896694,0.254925208417942,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.40619,1.09,0.333,214,0.692,"sorafenib, tyrphostin.AG.1296, ponatinib, TG.101348, dovitinib, KW.2449",0.47755576649368,0.159893905543242,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",-0.23011,-0.572,0.927,1446,0.938,"hydrocortisone",0.0329202658555029,0.0277971616209356,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.34743,-0.873,0.595,1341,0.865,"diazooxonorleucine, latrepirdine, JNJ.16259685",0.22548303427145,0.0629838925351858,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.34627,-0.868,0.598,1042,0.843,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin",0.223298816011589,0.0741724253752577,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.47933,1.28,0.189,130,0.554,"GSK1838705A, PHA.848125",0.723538195826756,0.25649023527157,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.42817,1.14,0.329,69,0.698,"narlaprevir, mericitabine",0.482804102050026,0.156144577376839,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.61769,-1.54,0.0652,1119,0.375,"R306465, vorinostat, scriptaid, nexturastat.a, entinostat, PCI.24781, pyroxamide, panobinostat, M.344, SB.939, tacedinaline, romidepsin, JNJ.26481585",1.18575240426808,0.425968732272281,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",-0.4662,-1.18,0.272,1097,0.771,"astemizole, zolantidine, terfenadine, BF2.649, lafutidine, famotidine, ranitidine, chloropyramine",0.565431095965801,0.112945621949043,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",0.65288,1.77,0.0271,361,0.574,"atorvastatin, mevastatin, fluvastatin",1.56703070912559,0.241088107602027,FALSE
+"H2126","Pearson.est","HSP inhibitor",0.26607,0.706,0.798,212,1,"SNX.2112, NMS.E973, BIIB021, SNX.5422",0.0979971086492706,0,FALSE
+"H2126","Pearson.est","JAK inhibitor",-0.33337,-0.855,0.63,1282,0.839,"TG.02, CEP.33779, pacritinib",0.200659450546418,0.0762380391712997,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.42473,1.14,0.27,146,0.698,"sorafenib, regorafenib, masitinib, OSI.930",0.568636235841013,0.156144577376839,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.54854,-1.37,0.131,1423,0.613,"RITA",0.882728704344236,0.212539525481585,FALSE
+"H2126","Pearson.est","MEK inhibitor",-0.30026,-0.765,0.739,847,0.848,"refametinib, cobimetinib, MEK162, TAK.733, nobiletin, PD.184352, PD.98059, selumetinib, BIX.02188",0.131355561605174,0.0716041477432862,FALSE
+"H2126","Pearson.est","MET inhibitor",-0.3654,-0.911,0.555,1133,0.826,"NVP.BVU972, PF.04217903, INC.280",0.255707016877324,0.0830199526796178,FALSE
+"H2126","Pearson.est","microtubule inhibitor",0.29409,0.776,0.708,189,0.996,"cabazitaxel, podophyllotoxin, vinblastine",0.149966742310231,0.00174066157630127,FALSE
+"H2126","Pearson.est","mTOR inhibitor",-0.46825,-1.18,0.267,893,0.771,"torin.1, SB.2343, torin.2, ku.0063794, LY303511, PKI.179, WYE.125132, sirolimus, everolimus, deforolimus, WAY.600, AZD8055, PI.103, PF.05212384, GDC.0980, GSK2126458, temsirolimus, LY3023414, palomid.529, PP242",0.573488738635425,0.112945621949043,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.27417,-0.692,0.851,1106,0.895,"IKK.2.inhibitor.V, bindarit, tyloxapol",0.0700704399154121,0.048176964684088,FALSE
+"H2126","Pearson.est","opioid receptor agonist",0.30646,0.81,0.649,222,0.997,"spiradoline, trimebutine",0.187755303199631,0.00130484168834428,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",0.40443,1.09,0.339,9,0.692,"talmapimod",0.469800301796918,0.159893905543242,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.53465,1.44,0.101,340,0.437,"niraparib, olaparib, AZD2461, talazoparib",0.995678626217357,0.359518563029578,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.42315,1.13,0.304,224,0.681,"sorafenib, regorafenib, masitinib, ponatinib, dovitinib, axitinib, nintedanib, linifanib",0.517126416391246,0.166852888087215,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",-0.24598,-0.615,0.925,1345,0.953,"mycophenolate.mofetil",0.0338582672609674,0.0209070993616736,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",-0.53259,-1.34,0.152,1151,0.569,"zardaverine, EMD.53998, GSK256066, anagrelide, cilostamide",0.818156412055227,0.244887733604929,FALSE
+"H2126","Pearson.est","PI3K inhibitor",-0.3827,-0.969,0.487,951,0.778,"taselisib, LY303511, PKI.179, TG100.115, YM.201636, TG.100713, alpelisib, PI.103, PF.05212384, GDC.0980, GSK2126458, AZD6482, PI.828, LY3023414, idelalisib, CUDC.907",0.312471038785366,0.109020403010311,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.8043,2.15,0.00248,289,0.0508,"volasertib, NMS.1286937, rigosertib, GW.843682X, BI.2536, GSK461364, HMN.214",2.60554831917378,1.29413628771608,TRUE
+"H2126","Pearson.est","potassium channel blocker",-0.78218,-1.96,0.00168,1220,0.0553,"meglitinide, oleoylethanolamide, ibutilide",2.77469071827414,1.2572748686953,TRUE
+"H2126","Pearson.est","PPAR receptor agonist",-0.67438,-1.7,0.0357,1309,0.205,"S26948, oleoylethanolamide, GW.501516, clofibrate",1.44733178388781,0.688246138944246,TRUE
+"H2126","Pearson.est","progesterone receptor agonist",0.24815,0.669,0.863,359,0.918,"norethindrone, norgestrel, nomegestrol.acetate, melengestrol.acetate",0.0639892042847904,0.0371573187987575,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.46738,1.26,0.2,392,0.551,"delanzomib, MG.132, oprozomib, ixazomib",0.698970004336019,0.258848401148215,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.28955,0.772,0.721,400,0.971,"anguidine, mercaptopurine, thiostrepton, clofoctol, harringtonine, puromycin, cycloheximide",0.142064735280571,0.0127807700919951,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.46647,-1.17,0.263,1355,0.743,"BMS.599626, CP.724714",0.580044251510242,0.129011186239425,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.42529,1.08,0.358,260,0.678,"sorafenib, regorafenib, SB.590885, RAF265",0.446116973356126,0.168770306132937,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.519,1.34,0.152,43,0.57,"sorafenib, regorafenib",0.818156412055227,0.244125144327509,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.48369,1.3,0.166,219,0.556,"LE.135, fenretinide, tamibarotene",0.779891911959945,0.254925208417942,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.57459,1.51,0.118,71,0.466,"triapine, cladribine",0.928117992693875,0.33161408331,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",-0.69804,-1.78,0.0158,1249,0.146,"ipsapirone, NAN.190, aripiprazole",1.80134291304558,0.835647144215563,TRUE
+"H2126","Pearson.est","serotonin receptor antagonist",-0.47324,-1.2,0.252,1447,0.843,"aripiprazole",0.598599459218456,0.0741724253752577,FALSE
+"H2126","Pearson.est","sodium channel blocker",-0.24006,-0.6,0.92,1300,0.941,"ajmaline, lappaconite",0.0362121726544447,0.0264103765727431,FALSE
+"H2126","Pearson.est","src inhibitor",-0.39296,-0.98,0.488,1210,0.786,"bosutinib, PP.1, PP.2",0.311580177997289,0.104577453960592,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.54109,1.46,0.123,390,0.447,"chlormidazole, sulconazole, lanoconazole, posaconazole",0.910094888560602,0.349692476868064,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",-0.33501,-0.841,0.635,888,0.809,"repsox, SB.525334, LY2109761, D.4476",0.197226274708024,0.0920514783877277,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.24585,0.675,0.841,237,0.933,"trifluridine, capecitabine",0.0752040042020878,0.0301183562535,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.65994,1.76,0.0221,299,0.302,"etoposide.phosphate, idarubicin, TAS.103, topotecan, mitoxantrone, doxorubicin, voreloxin, nemorubicin, exatecan.mesylate, amonafide, SN.38, teniposide, daunorubicin, valrubicin, amsacrine",1.65560772631489,0.519993057042849,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.56795,1.5,0.0879,498,0.429,"verubulin, BNC105, vindesine, podophyllotoxin, docetaxel, taltobulin, dolastatin.10, vinblastine, albendazole, combretastatin.A.4, fenbendazole, vincristine, indibulin, CYT.997, mebendazole, plinabulin, epothilone.b, flubendazole, fosbretabulin, KX2.391, parbendazole, oxibendazole, nocodazole, paclitaxel, ABT.751",1.05601112492623,0.367542707815276,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",0.20156,0.533,0.971,103,0.99,"sorafenib, regorafenib, hypericin",0.0127807700919951,0.00436480540245009,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",0.25982,0.698,0.822,319,0.952,"sorafenib, regorafenib, tivozanib, OSI.930, dovitinib, axitinib, nintedanib, linifanib, RAF265, ENMD.2076, lenvatinib",0.0851281824599496,0.0213630516155257,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.5325,-1.36,0.154,1059,0.577,"tacalcitol, maxacalcitol, calcitriol, paricalcitol",0.812479279163537,0.238824186844269,FALSE
+"H520","Pearson.est","EGFR inhibitor",-0.42616,-1.06,0.406,1035,0.742,"BMS.599626, WZ.4002, TAK.285, salvianolic.acid.B, dovitinib, rociletinib, dacomitinib, AZD8931, brigatinib, ARRY.334543, XL.647, AEE788, gefitinib, lapatinib, CP.724714, GW.583340, tucatinib, neratinib",0.391473966422806,0.129596094720973,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",-0.41953,-1.03,0.423,843,0.673,"GZD824, dasatinib, bafetinib, bosutinib, flumatinib, ponatinib, metatinib, imatinib, nilotinib",0.373659632624958,0.171984935776023,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",0.33826,0.907,0.53,184,0.716,"nefiracetam, nicotine",0.275724130399211,0.145086977692144,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",-0.53551,-1.31,0.147,792,0.663,"darifenacin, dicycloverine, methscopolamine, hyoscyamine, diphemanil",0.832682665251824,0.178486471595227,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",0.31159,0.808,0.66,999,0.798,"istradefylline, SCH.58261, MRS.1220, sulmazole, PSB.1115, CGS.15943, theophylline",0.180456064458131,0.0979971086492706,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.28543,0.748,0.771,409,0.864,"oxymetazoline, isoxsuprine, terbutaline, metaraminol, buphenine, ritodrine, epinephrine, clenbuterol, isoetharine",0.112945621949043,0.0634862575211067,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",-0.39914,-0.98,0.478,1056,0.697,"metoprolol, vincamine, practolol, prazosin, idazoxan, carvedilol, RS.17053, dihydroergocristine",0.320572103387881,0.156767221901991,FALSE
+"H520","Pearson.est","AKT inhibitor",0.34423,0.916,0.526,371,0.761,"MK.2206, palomid.529, ONC201, AT7867, GDC.0068",0.279014255846261,0.118615343229427,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.42793,-1.05,0.411,1090,0.683,"AZD3463, crizotinib, AP26113, DMH1, brigatinib, CEP.37440",0.386158178123931,0.165579296318467,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.61091,1.61,0.0494,246,0.277,"RU.58841, nilutamide, enzalutamide",1.30627305107635,0.557520230935551,FALSE
+"H520","Pearson.est","antioxidant",0.42352,1.12,0.307,123,0.633,"benfotiamine, mesna",0.512861624522813,0.198596289982645,FALSE
+"H520","Pearson.est","AP inhibitor",0.61889,1.63,0.0471,47,0.359,"GDC.0152, birinapant",1.3269790928711,0.444905551421681,FALSE
+"H520","Pearson.est","ATPase inhibitor",-0.21142,-0.521,0.978,1062,1,"NMS.873, digitoxin, digoxin, evodiamine",0.00966114521239857,0,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.29897,-0.736,0.771,1034,0.849,"MK.8745, CYC116, barasertib.HQPA, SNS.314, AT.9283, ENMD.2076, CCT137690, danusertib, PHA.680632",0.112945621949043,0.0710923097560473,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.39219,-0.976,0.476,1048,0.684,"josamycin, valnemulin, dirithromycin",0.322393047279507,0.164943898279884,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.76902,2.04,0.00735,32,0.0461,"finafloxacin, novobiocin, trovafloxacin",2.13371266091581,1.33629907461035,TRUE
+"H520","Pearson.est","BCL inhibitor",-0.34462,-0.83,0.666,1235,0.77,"navitoclax, ABT.737, obatoclax",0.176525770829699,0.113509274827518,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.57274,-1.41,0.119,843,0.712,"GZD824, dasatinib, bafetinib, bosutinib, flumatinib, ponatinib, metatinib, imatinib, nilotinib",0.924453038607469,0.147520006363144,FALSE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.25879,0.678,0.818,182,0.899,"lorazepam, nefiracetam",0.087246696328677,0.0462403082667712,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.64632,-1.58,0.0537,932,1,"JQ1...., I.BET151, OTX015, PFI.1, bromosporine, I.BET.762",1.27002571430044,0,FALSE
+"H520","Pearson.est","calcium channel blocker",0.34296,0.903,0.551,213,0.696,"efonidipine.monoethanolate, cinnarazine, SR.33805, pranidipine",0.258848401148215,0.157390760389438,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",-0.44017,-1.09,0.34,1285,0.77,"SB.225002, UNBS.5162",0.468521082957745,0.113509274827518,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.46221,-1.13,0.301,1140,0.792,"BMS.265246, CR8..R., alvocidib, aminopurvalanol.a, indisulam, PHA.848125, arcyriaflavin.a, dinaciclib, AT.7519, BMS.387032",0.521433504406157,0.101274818410506,FALSE
+"H520","Pearson.est","CHK inhibitor",-0.57109,-1.4,0.115,1353,0.661,"SB.218078, PF.477736",0.939302159646388,0.17979854051436,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",0.25026,0.66,0.858,270,0.891,"metoxibutropate, pterostilbene, acetylsalicylsalicylic.acid, phenylbutazone, indoprofen, suxibuzone, FR.122047",0.0665127121512946,0.0501222959631252,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.24566,0.635,0.896,1094,0.891,"cobicistat, itraconazole, PF.4981517, clotrimazole, morin, eplerenone, metyrapone",0.0476919903378748,0.0501222959631252,FALSE
+"H520","Pearson.est","DNA alkylating agent",-0.45512,-1.14,0.295,965,0.809,"melphalan, dacarbazine, ifosfamide, temozolomide, dianhydrogalactitol, mitomycin.c",0.530177984021837,0.0920514783877277,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.36565,-0.905,0.543,965,0.707,"melphalan, pibenzimol, teroxirone, oxaliplatin, valrubicin, primaquine, mechlorethamine, bendamustine",0.265200170411153,0.150580586203101,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.41706,-1.05,0.396,1244,0.683,"disulfiram, SGI.1027",0.402304814074488,0.165579296318467,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",0.55435,1.46,0.115,209,0.386,"famciclovir, cephalomannine, adefovir.dipivoxil",0.939302159646388,0.413412695328245,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",0.35383,0.938,0.505,100,0.752,"altretamine, CB.10.277, estramustine.phosphate",0.296708621881339,0.123782159408358,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",0.41703,1.09,0.347,302,0.579,"clebopride, acetophenazine, oxiperomide, UH.232...., nemonapride, raclopride, remoxipride, paliperidone",0.459670525209126,0.237321436272564,FALSE
+"H520","Pearson.est","estrogen receptor agonist",-0.4285,-1.07,0.357,1268,0.751,"equol, levonorgestrel",0.447331783887807,0.124360062995832,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",-0.4091,-1.01,0.425,950,0.687,"clomifene, danazol, toremifene, tamoxifen",0.371611069949688,0.16304326294045,FALSE
+"H520","Pearson.est","FGFR inhibitor",-0.59727,-1.47,0.0841,1333,0.859,"erdafitinib, nintedanib, regorafenib, lenvatinib",1.07520400420209,0.0660068361687577,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.35199,-0.86,0.639,961,0.761,"TG.02, sorafenib, lestaurtinib, ponatinib, tyrphostin.AG.1296, dovitinib, ENMD.2076, TG.101348, quizartinib",0.1944991418416,0.118615343229427,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",-0.45409,-1.14,0.291,1298,0.809,"methylprednisolone, flumethasone, fluorometholone, triamcinolone.acetonide, halcinonide, fluticasone.propionate, betamethasone, deflazacort",0.536107011014093,0.0920514783877277,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",-0.30263,-0.758,0.763,1318,0.837,"LY456236, ACDPP, CGP.37849",0.11747546204512,0.07727454200674,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.49472,1.32,0.175,132,0.463,"LY2090314, kenpaullone",0.756961951313706,0.334419008982047,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.55445,-1.38,0.131,1025,0.648,"lestaurtinib, AZD3463, PHA.848125, danusertib",0.882728704344236,0.188424994129407,FALSE
+"H520","Pearson.est","HCV inhibitor",-0.58066,-1.43,0.11,1251,0.739,"mericitabine, narlaprevir",0.958607314841775,0.131355561605174,FALSE
+"H520","Pearson.est","HDAC inhibitor",0.35065,0.912,0.562,142,0.736,"romidepsin, JNJ.26481585, R306465, RGFP966, tacedinaline",0.250263684430939,0.133122185662501,FALSE
+"H520","Pearson.est","histamine receptor antagonist",0.37699,0.977,0.464,259,0.748,"epinastine, ranitidine, famotidine, ICI.162846, terfenadine, BF2.649",0.333482019445119,0.126098402135539,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.79889,2.07,0,296,0.0572,"pitavastatin, fluvastatin, lovastatin, mevastatin, atorvastatin, simvastatin",Inf,1.24260397120698,TRUE
+"H520","Pearson.est","HSP inhibitor",0.42213,1.14,0.27,312,0.684,"BIIB021, SNX.5422, KW.2478, PU.H71",0.568636235841013,0.164943898279884,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.4924,-1.21,0.243,920,0.823,"AZ960, TG.02, lestaurtinib, TG.101209, atiprimod, AT.9283, CEP.33779, baricitinib, LY2784544, TG.101348",0.614393726401688,0.0846001647877302,FALSE
+"H520","Pearson.est","KIT inhibitor",-0.53692,-1.32,0.167,1259,0.693,"masitinib, imatinib, pazopanib, regorafenib, lenvatinib",0.777283528852417,0.159266765388193,FALSE
+"H520","Pearson.est","MDM inhibitor",0.67715,1.76,0.0289,44,0.243,"RITA, serdemetan",1.53910215724345,0.614393726401688,TRUE
+"H520","Pearson.est","MEK inhibitor",0.78307,2.12,0.00276,114,0.0769,"PD.184352, AZD8330, TAK.733, refametinib, Ro.4987655, PD.318088, cobimetinib, PD.0325901, trametinib, MEK162, AS.703026, selumetinib",2.55909091793478,1.11407366019857,TRUE
+"H520","Pearson.est","MET inhibitor",0.26917,0.719,0.806,456,0.877,"AMG458, PF.04217903, INC.280, PHA.665752",0.0936649581949093,0.0570004066339595,FALSE
+"H520","Pearson.est","microtubule inhibitor",-0.52306,-1.29,0.178,1096,0.665,"triclabendazole, vinflunine, cabazitaxel, colchicine, D.64131",0.749579997691106,0.177178354696895,FALSE
+"H520","Pearson.est","mTOR inhibitor",-0.37906,-0.958,0.474,1051,0.658,"torin.1, AZD2014, PKI.179, deforolimus, PF.05212384, AZD8055, MLN0128, WYE.354, PF.04691502, WYE.125132",0.324221658325915,0.181774106386044,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",0.44344,1.15,0.281,2,0.716,"BAY.11.7085",0.55129368009492,0.145086977692144,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.43368,1.13,0.302,300,0.655,"ADL5859, cebranopadol, BW.180C",0.519993057042849,0.183758700008217,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.42114,-1.05,0.396,1446,0.683,"talmapimod",0.402304814074488,0.165579296318467,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.21072,-0.511,0.971,779,0.995,"endo.IWR.1, E7449, niraparib, PJ.34",0.0127807700919951,0.00217691925427455,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.39545,-0.971,0.49,1259,0.673,"masitinib, imatinib, pazopanib, nintedanib, regorafenib, lenvatinib, crenolanib",0.309803919971486,0.171984935776023,FALSE
+"H520","Pearson.est","phosphatase inhibitor",0.33585,0.88,0.595,99,0.706,"bis.maltolato.oxovanadium.IV., alexidine",0.22548303427145,0.151195298948196,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",0.54111,1.42,0.119,292,0.364,"papaverine, anagrelide, GSK256066, zardaverine, EMD.53998",0.924453038607469,0.438898616350944,FALSE
+"H520","Pearson.est","PI3K inhibitor",-0.31982,-0.792,0.707,984,0.808,"idelalisib, NVP.BEZ235, alpelisib, BGT226, PKI.179, PIK.75, YM.201636, taselisib, PI3K.IN.2, ZSTK.474, PF.05212384, PF.04691502",0.150580586203101,0.0925886392254138,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.83067,-2.05,0,1297,0.0322,"HMN.214, GW.843682X, GSK461364, BI.2536, volasertib, NMS.1286937",Inf,1.49214412830417,TRUE
+"H520","Pearson.est","potassium channel blocker",0.53756,1.44,0.115,26,0.375,"meglitinide",0.939302159646388,0.425968732272281,FALSE
+"H520","Pearson.est","PPAR receptor agonist",0.55589,1.51,0.0735,321,0.359,"S26948, pterostilbene, clofibrate, fenofibrate",1.1337126609158,0.444905551421681,FALSE
+"H520","Pearson.est","progesterone receptor agonist",-0.1938,-0.479,0.983,907,0.985,"nomegestrol.acetate, melengestrol.acetate, danazol, levonorgestrel",0.00744648216786438,0.00656376950238827,FALSE
+"H520","Pearson.est","proteasome inhibitor",-0.27153,-0.674,0.861,874,0.91,"delanzomib, oprozomib, MG.132, bortezomib, carfilzomib",0.0649968485463452,0.0409586076789064,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.50035,-1.2,0.264,1415,0.799,"bruceantin, harringtonine, anguidine, homoharringtonine",0.578396073130169,0.0974532206860086,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.63181,-1.55,0.0456,1193,0.943,"PP.121, mubritinib, tyrphostin.A9, AV.412, CP.724714",1.34103515733556,0.0254883072626717,FALSE
+"H520","Pearson.est","RAF inhibitor",-0.38302,-0.935,0.523,972,0.678,"PLX.4720, sorafenib, SB.590885, AZ.628, regorafenib, TAK.632",0.281498311132726,0.168770306132937,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.4226,-1.04,0.399,934,0.678,"cabozantinib, sorafenib, regorafenib",0.399027104313252,0.168770306132937,FALSE
+"H520","Pearson.est","retinoid receptor agonist",-0.48036,-1.19,0.262,1204,0.775,"bexarotene, tamibarotene, fenretinide, adarotene",0.581698708680255,0.11069829749369,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.40181,-0.997,0.457,1327,0.688,"LY2334737, pentostatin",0.34008379993015,0.162411561764489,FALSE
+"H520","Pearson.est","serotonin receptor agonist",0.60578,1.62,0.0629,1,0.31,"aripiprazole",1.20134935455473,0.508638306165727,FALSE
+"H520","Pearson.est","serotonin receptor antagonist",0.43105,1.09,0.311,180,0.579,"aripiprazole, lerisetron, tropisetron",0.507239610973163,0.237321436272564,FALSE
+"H520","Pearson.est","sodium channel blocker",0.40666,1.09,0.331,64,0.579,"ajmaline, A.803467",0.480172006224281,0.237321436272564,FALSE
+"H520","Pearson.est","src inhibitor",-0.45555,-1.12,0.337,1077,0.776,"PP.1, TG.100572, masitinib, KX2.391, saracatinib",0.472370099128661,0.110138278741812,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",-0.58558,-1.45,0.098,1083,0.789,"ketoconazole, lanoconazole, posaconazole, chlormidazole",1.00877392430751,0.10292299679058,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",0.3516,0.942,0.512,941,0.779,"D.4476, LY2109761, SB.431542, repsox, adaprev, SB.525334",0.290730039024169,0.108462542327436,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",-0.43257,-1.07,0.382,1313,0.751,"doxifluridine",0.417936637088291,0.124360062995832,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",-0.54462,-1.32,0.178,1137,0.693,"licochalcone.a, valrubicin, etoposide, daunorubicin, etoposide.phosphate, doxorubicin, teniposide, amonafide, idarubicin, nemorubicin, TAS.103, dexrazoxane, exatecan.mesylate, amsacrine, mitoxantrone, SN.38",0.749579997691106,0.159266765388193,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.59443,-1.48,0.0864,1135,1,"vindesine, vincristine, plinabulin, docetaxel, epothilone.d, epothilone.b, taltobulin, dolastatin.10, paclitaxel, ABT.751, mebendazole, CYT.997, oxibendazole, fenbendazole, KX2.391",1.06348625752111,0,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",-0.45019,-1.1,0.332,894,0.784,"dasatinib, bafetinib, cabozantinib, sorafenib, tyrphostin.AG.99, BMS.599626, PP.121, mubritinib, tivantinib, tyrphostin.A9, aminopurvalanol.a, AV.412, CP.724714, regorafenib",0.478861916295964,0.105683937315562,FALSE
+"H520","Pearson.est","VEGFR inhibitor",-0.33548,-0.836,0.64,1247,0.779,"ENMD.2076, pazopanib, foretinib, XL.647, nintedanib, AEE788, regorafenib, lenvatinib",0.193820026016113,0.108462542327436,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",-0.39273,-0.962,0.487,1416,0.669,"doxercalciferol",0.312471038785366,0.174573882232177,FALSE
+"H460","Pearson.est","EGFR inhibitor",-0.15743,-0.402,0.998,881,0.997,"osimertinib, brigatinib, WZ8040, tyrphostin.AG.1478, vandetanib, tucatinib, CGP.52411, BMS.599626, PD.168393, BIBU.1361, lapatinib, neratinib, rociletinib, WZ.4002, dovitinib, CP.724714, salvianolic.acid.B",0.000869458712628891,0.00130484168834428,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.48144,-1.22,0.226,1269,0.669,"ponatinib, metatinib, nilotinib, imatinib",0.645891560852599,0.174573882232177,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.41258,-1.05,0.376,1353,0.566,"oxiracetam",0.424812155072339,0.247183568811729,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.71905,1.9,0.0168,115,0.192,"iododexetimide, diphemanil, darifenacin",1.77469071827414,0.71669877129645,TRUE
+"H460","Pearson.est","adenosine receptor antagonist",0.46854,1.25,0.209,345,0.513,"CGS.15943, MRS.1220, SCH.58261",0.679853713888946,0.289882634888184,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",0.55126,1.51,0.078,72,0.328,"ritodrine, isoxsuprine, methyldopa, xylazine",1.10790539730952,0.484126156288321,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",0.42837,1.12,0.295,287,0.617,"prazosin, RS.17053, atenolol...., metoprolol, practolol, atenolol......",0.530177984021837,0.209714835966758,FALSE
+"H460","Pearson.est","AKT inhibitor",0.31824,0.841,0.657,183,0.794,"GDC.0068, palomid.529, GSK2110183, triciribine",0.182434630440219,0.100179497572904,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.54912,1.45,0.13,202,0.338,"GW.788388, lorlatinib, NVP.TAE684, SB.505124",0.886056647693163,0.471083299722345,FALSE
+"H460","Pearson.est","androgen receptor antagonist",0.36209,0.96,0.468,544,0.738,"nilutamide, enzalutamide, bicalutamide, flutamide",0.329754146925876,0.131943638176958,FALSE
+"H460","Pearson.est","antioxidant",-0.41131,-1.05,0.389,1085,0.566,"trolox, chlorogenic.acid, mesna",0.410050398674292,0.247183568811729,FALSE
+"H460","Pearson.est","AP inhibitor",0.28153,0.744,0.722,78,0.809,"tanshinone.i",0.141462802430361,0.0920514783877277,FALSE
+"H460","Pearson.est","ATPase inhibitor",-0.31124,-0.805,0.693,990,0.769,"omeprazole, NMS.873, ouabain, digitoxigenin, digoxin, digitoxin",0.159266765388193,0.114073660198569,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.5357,-1.4,0.119,1016,0.496,"alisertib, AMG900, KW.2449, GSK1070916, CCT137690, CCT129202, PF.03814735, CYC116, MK.8745, hesperadin, ENMD.2076, MK.5108, PHA.680632",0.924453038607469,0.304518323509803,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.4366,-1.11,0.326,1208,0.586,"tedizolid, azalomycin.b, radezolid, valnemulin",0.486782399932061,0.232102383981909,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.59799,1.62,0.0563,193,0.374,"sparfloxacin, norfloxacin, nadifloxacin, trovafloxacin",1.24949160514865,0.42712839779952,FALSE
+"H460","Pearson.est","BCL inhibitor",-0.50509,-1.29,0.181,1145,0.562,"ABT.737, navitoclax, TW.37, venetoclax",0.742321425130815,0.250263684430939,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.56204,-1.43,0.114,1269,0.587,"ponatinib, metatinib, nilotinib, imatinib",0.943095148663527,0.231361898752386,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.5712,1.51,0.0637,220,0.328,"indiplon, gamma.aminobutyric.acid, CL.218872, temazepam, nefiracetam, piperazine",1.19586056766465,0.484126156288321,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.40614,-1.05,0.383,1121,0.566,"bromosporine, I.BET.762",0.416801226031377,0.247183568811729,FALSE
+"H460","Pearson.est","calcium channel blocker",0.29375,0.751,0.757,399,0.825,"SKF.96365, efonidipine.monoethanolate, pranidipine, tetrandrine",0.120904120499927,0.0835460514500749,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.49699,-1.3,0.163,1195,0.578,"navarixin, RS.504393",0.787812395596042,0.238072161579471,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.68197,-1.77,0.0158,1087,0.266,"NU6027, AT.7519, TG.02, PHA.848125, dinaciclib, BMS.387032, AZD5438, aminopurvalanol.a, indirubin, abemaciclib, palbociclib, alvocidib, PHA.793887, BMS.265246, ribociclib",1.80134291304558,0.575118363368933,FALSE
+"H460","Pearson.est","CHK inhibitor",-0.42986,-1.13,0.297,973,0.574,"AZD7762, SB.218078, LY2603618, SCH.900776",0.527243550682788,0.241088107602027,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",0.27113,0.726,0.807,278,0.809,"naproxen, pterostilbene, metoxibutropate, phenylbutazone, FK.3311",0.0931264652779296,0.0920514783877277,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",0.71109,1.86,0.0147,230,0.165,"itraconazole, morin, metyrapone, eplerenone",1.83268266525182,0.782516055786094,TRUE
+"H460","Pearson.est","DNA alkylating agent",-0.43757,-1.13,0.313,986,0.574,"carmustine, melphalan, estramustine, TH.302, dianhydrogalactitol, carboplatin, mitomycin.c",0.504455662453552,0.241088107602027,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.4731,-1.18,0.286,1356,0.585,"teroxirone, carboplatin, valrubicin, mechlorethamine",0.543633966870957,0.23284413391782,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.46625,-1.19,0.259,1304,0.596,"disulfiram, decitabine",0.586700235918748,0.224753740259764,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",0.46545,1.24,0.212,290,0.493,"famciclovir, cephalomannine, cidofovir, menadione",0.673664139071249,0.30715308072277,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.42548,-1.09,0.347,1213,0.576,"enocitabine, capecitabine, floxuridine, anisomycin, cyclocytidine, mitomycin.c",0.459670525209126,0.239577516576788,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",0.28946,0.778,0.732,201,0.84,"clebopride, nemonapride, domperidone, sertindole",0.135488918941608,0.0757207139381184,FALSE
+"H460","Pearson.est","estrogen receptor agonist",-0.28956,-0.741,0.777,1132,0.823,"equol, PPT",0.109578981199086,0.0846001647877302,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",0.58023,1.56,0.0907,219,0.34,"toremifene, raloxifene, fulvestrant",1.0423927129399,0.468521082957745,FALSE
+"H460","Pearson.est","FGFR inhibitor",0.40683,1.1,0.33,196,0.583,"lucitanib, orantinib, erdafitinib",0.481486060122112,0.234331445240986,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.41817,-1.05,0.381,1040,0.566,"midostaurin, KW.2449, TG.02, sunitinib, quizartinib, pacritinib, ponatinib, dovitinib, ENMD.2076, TG.101348",0.419075024324381,0.247183568811729,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",0.27046,0.719,0.814,17,0.794,"triamcinolone.acetonide, piretanide",0.0893755951107988,0.100179497572904,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.41508,1.11,0.317,261,0.6,"JNJ.16259685, kynurenic.acid, MTPG, CGP.37849",0.498940737782249,0.221848749616356,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",0.32811,0.878,0.573,265,0.823,"CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.24184537803261,0.0846001647877302,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.47753,-1.21,0.238,717,0.651,"GW.441756, GSK1838705A, danusertib, lestaurtinib, PHA.848125",0.623423042943488,0.186419011431808,FALSE
+"H460","Pearson.est","HCV inhibitor",-0.38894,-0.994,0.464,1236,0.601,"mericitabine, narlaprevir",0.333482019445119,0.22112552799726,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.55081,-1.42,0.109,1004,0.549,"NSC.3852, panobinostat, romidepsin, SB.939, scriptaid, mocetinostat, PCI.24781, JNJ.26481585, AR.42, M.344, resminostat, vorinostat, entinostat, RG2833, dacinostat, trichostatin.a, chidamide, givinostat",0.962573502059376,0.260427655549908,FALSE
+"H460","Pearson.est","histamine receptor antagonist",0.3674,0.959,0.46,299,0.708,"famotidine, chloropyramine, epinastine, cimetidine, tecastemizole, lafutidine, ebastine",0.337242168318426,0.149966742310231,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.69079,1.85,0.0189,288,0.133,"lovastatin, atorvastatin, mevastatin, fluvastatin",1.72353819582676,0.876148359032914,TRUE
+"H460","Pearson.est","HSP inhibitor",-0.44508,-1.13,0.273,1298,0.574,"NVP.AUY922, PU.H71, VER.49009, ganetespib, tanespimycin",0.563837352959244,0.241088107602027,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.53032,-1.38,0.142,1125,0.497,"TG.02, TG.101209, WHI.P154, AZ960, pacritinib, TG.101348, filgotinib",0.847711655616944,0.303643611266668,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.31484,-0.809,0.674,1144,0.781,"KI.8751, sunitinib, OSI.930, vatalanib, imatinib",0.17134010346468,0.1073489661227,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.6425,-1.64,0.0384,1138,0.458,"RITA, CGM097, nutlin.3, idasanutlin",1.41566877563247,0.339134521996131,FALSE
+"H460","Pearson.est","MEK inhibitor",-0.56662,-1.47,0.0841,1139,0.551,"cobimetinib, nobiletin, PD.318088, PD.184352, Ro.4987655, PD.0325901, MEK162, AZD8330, TAK.733, trametinib, selumetinib, AS.703026",1.07520400420209,0.258848401148215,FALSE
+"H460","Pearson.est","MET inhibitor",0.36524,0.964,0.467,449,0.766,"AMG458, INC.280, PF.04217903, PHA.665752",0.330683119433888,0.115771230367396,FALSE
+"H460","Pearson.est","microtubule inhibitor",-0.32113,-0.809,0.696,1284,0.781,"vinflunine, D.64131",0.157390760389438,0.1073489661227,FALSE
+"H460","Pearson.est","mTOR inhibitor",-0.39943,-1,0.436,895,0.61,"XL388, deforolimus, torin.1, WAY.600, voxtalisib, LY3023414, sirolimus, PP242, AZD8055, WYE.354, WYE.125132, LY303511, temsirolimus, ku.0063794, GDC.0980, AZD2014, MLN0128, everolimus, NVP.BEZ235",0.360513510731414,0.214670164989233,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",0.28782,0.773,0.721,221,0.82,"tyloxapol, parthenolide...., bindarit",0.142064735280571,0.0861861476162833,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.4652,-1.19,0.275,1367,0.596,"salvinorin.a",0.560667306169737,0.224753740259764,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",0.42433,1.13,0.31,428,0.638,"TAK.715, SB.239063, CMPD.1",0.508638306165727,0.195179321278838,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.40586,-1.03,0.402,1142,0.58,"endo.IWR.1, niraparib, talazoparib, olaparib",0.39577394691553,0.236572006437063,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.4805,-1.19,0.271,1130,0.596,"linifanib, KI.8751, trapidil, sunitinib, vatalanib, ponatinib, crenolanib, dovitinib, axitinib, imatinib",0.567030709125594,0.224753740259764,FALSE
+"H460","Pearson.est","phosphatase inhibitor",0.59818,1.57,0.0596,486,0.381,"BVT.948, alexidine, AS.1949490, menadione, mycophenolic.acid, mycophenolate.mofetil, sodium.stibogluconate",1.22475374025976,0.419075024324381,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",0.31354,0.843,0.623,289,0.821,"enoximone, GSK256066, avanafil",0.20551195334083,0.0856568428805592,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.24252,-0.613,0.907,1301,0.929,"GDC.0980, PIK.75, NVP.BEZ235",0.0423927129399047,0.0319842860063582,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.80764,-2.06,0.00187,1163,0.0648,"HMN.214, GSK461364, GW.843682X, BI.2536, rigosertib, NMS.1286937, volasertib",2.7281583934635,1.18842499412941,TRUE
+"H460","Pearson.est","potassium channel blocker",0.3973,1.04,0.406,13,0.656,"dofetilide",0.391473966422806,0.18309616062434,FALSE
+"H460","Pearson.est","PPAR receptor agonist",0.7643,2.04,0.00239,171,0.117,"pterostilbene, S26948, fenofibrate, GW.501516",2.62160209905186,0.931814138253838,TRUE
+"H460","Pearson.est","progesterone receptor agonist",0.48312,1.27,0.197,483,0.517,"norgestrel, norethindrone, norethindrone.acetate, dienogest, nomegestrol.acetate",0.705533773838407,0.286509456906058,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.56026,1.47,0.106,342,0.345,"oprozomib, delanzomib, ONX.0914, MG.132",0.97469413473523,0.462180904926726,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.26005,-0.654,0.857,1173,0.91,"tedizolid.phosphate, emetine, thiostrepton, homoharringtonine, anguidine",0.0670191780768018,0.0409586076789064,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.59982,-1.5,0.073,1296,0.637,"AV.412, CP.724714, mubritinib",1.13667713987954,0.19586056766465,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.33828,-0.868,0.623,1099,0.731,"CEP.32496, TAK.632, vemurafenib, dabrafenib",0.20551195334083,0.13608262304214,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",0.3316,0.857,0.607,76,0.828,"apatinib",0.216811308924742,0.0819696632151199,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.42137,-1.09,0.341,1050,0.576,"LE.135, CD.437, bexarotene, adarotene",0.467245621007502,0.239577516576788,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.45817,-1.16,0.296,917,0.595,"cladribine, triapine, pentostatin, clofarabine, LY2334737, gemcitabine, fludarabine",0.528708288941061,0.22548303427145,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.30265,-0.758,0.746,1374,0.818,"SB.200646, SB.216641",0.127261172527331,0.087246696328677,FALSE
+"H460","Pearson.est","sodium channel blocker",0.3101,0.801,0.697,357,0.832,"cibenzoline, benzocaine, benzethonium, oxcarbazepine, ajmaline",0.156767221901991,0.0798766737092761,FALSE
+"H460","Pearson.est","src inhibitor",-0.34407,-0.876,0.596,1227,0.738,"TG.100572, KX2.391",0.224753740259764,0.131943638176958,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.69164,-1.8,0.0144,1289,0.322,"lanoconazole, ketoconazole",1.84163750790475,0.492144128304169,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",0.50725,1.36,0.135,465,0.42,"LY2109761, repsox, SB.525334, D.4476",0.869666231504994,0.3767507096021,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.58002,-1.47,0.0915,1224,0.551,"capecitabine, trifluridine, carmofur",1.03857890593355,0.258848401148215,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.55579,-1.41,0.103,1357,0.52,"voreloxin, licochalcone.a, TAS.103, valrubicin, idarubicin, amsacrine, amonafide, mitoxantrone",0.987162775294828,0.283996656365201,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.57816,-1.5,0.0692,951,0.637,"podophyllotoxin, plinabulin, vinblastine, vindesine, nocodazole, CYT.997, fenbendazole, BNC105, dolastatin.10, docetaxel, taltobulin, epothilone.d, flubendazole, ABT.751, verubulin, combretastatin.A.4, parbendazole, fosbretabulin, KX2.391, epothilone.b",1.15989390554324,0.19586056766465,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.36431,-0.926,0.539,919,0.675,"tivantinib, vandetanib, dasatinib, NVP.TAE226, BMS.599626, UNC2250, hypericin, AMG.208, sunitinib, aminopurvalanol.a, AV.412, CP.724714, tyrphostin.AG.99, mubritinib",0.268411234813261,0.170696227168975,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.3832,-0.968,0.494,1130,0.624,"linifanib, KI.8751, MGCD.265, tivozanib, sunitinib, OSI.930, TG.100572, vatalanib, semaxanib, foretinib, golvatinib, dovitinib, ENMD.2076, axitinib",0.306273051076353,0.204815410317576,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",-0.52738,-1.33,0.157,1244,0.557,"ercalcitriol, tacalcitol, doxercalciferol",0.804100347590766,0.254144804826271,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.52411,1.36,0.141,399,0.845,"OSI.420, tyrphostin.AG.1478, erlotinib, BIBX.1382, gefitinib, WZ8040, BIBU.1361, CP.724714, icotinib, AZD8931, osimertinib, canertinib, dacomitinib, PD.153035, pelitinib, AST.1306, poziotinib, tyrphostin.AG.494, BMS.690514, afatinib, lapatinib, neratinib, ARRY.334543, XL.647, CGP.52411",0.85078088734462,0.0731432910503077,FALSE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.57572,-1.46,0.103,999,0.305,"metatinib, dasatinib, bafetinib, nilotinib, flumatinib, GZD824, ponatinib",0.987162775294828,0.515700160653214,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",0.29053,0.737,0.772,75,1,"nefiracetam",0.112382699664264,0,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",0.27836,0.711,0.798,427,0.975,"darifenacin, diphemanil, dicycloverine",0.0979971086492706,0.0109953843014632,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",0.84895,2.18,0,44,0.0115,"SCH.58261, CGS.15943, MRS.1220, PSB.1115",Inf,1.93930215964639,TRUE
+"H1299","Pearson.est","adrenergic receptor agonist",0.49404,1.29,0.181,341,0.707,"oxymetazoline, lidamidine, metaraminol, methyldopa, clenbuterol, isoxsuprine",0.742321425130815,0.150580586203101,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",0.35931,0.942,0.512,131,0.878,"levobunolol, atenolol...., imiloxan, dronedarone",0.290730039024169,0.0565054840938974,FALSE
+"H1299","Pearson.est","AKT inhibitor",0.49167,1.27,0.198,332,0.695,"CCT128930, uprosertib, GDC.0068, palomid.529, AZD5363",0.703334809738469,0.158015195409886,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41485,1.07,0.361,91,0.742,"NVP.TAE684, GW.788388",0.442492798094342,0.129596094720973,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",0.61489,1.58,0.0698,443,0.391,"enzalutamide, cyproterone.acetate, RU.58841",1.15614457737684,0.407823242604133,FALSE
+"H1299","Pearson.est","antioxidant",0.35859,0.913,0.549,511,0.87,"benfotiamine, taurine, chlorogenic.acid, mesna",0.260427655549908,0.0604807473813815,FALSE
+"H1299","Pearson.est","AP inhibitor",-0.46966,-1.2,0.247,1430,0.499,"idronoxil",0.607303046740334,0.30189945437661,FALSE
+"H1299","Pearson.est","ATPase inhibitor",-0.5271,-1.38,0.13,1107,0.334,"digitoxigenin, thonzonium, ouabain, k.strophanthidin, digoxin, oligomycin.a",0.886056647693163,0.476253533188435,FALSE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.41057,-1.07,0.392,1283,0.527,"MK.5108, CYC116, AMG900, aurora.a.inhibitor.i, CCT137690",0.406713932979543,0.278189384787453,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45826,-1.18,0.278,1269,0.479,"josamycin, valnemulin",0.555955204081924,0.319664486585437,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.1778,0.455,0.996,130,1,"finafloxacin",0.00174066157630127,0,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.3412,-0.905,0.54,1299,0.694,"gossypol, ABT.737",0.267606240177031,0.158640529545145,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.6032,-1.57,0.0683,999,0.274,"metatinib, dasatinib, bafetinib, nilotinib, flumatinib, GZD824, ponatinib",1.16557929631847,0.562249437179612,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.4891,1.24,0.215,241,0.71,"gamma.aminobutyric.acid, nefiracetam, lorazepam, piperazine, eprinomectin",0.667561540084395,0.148741651280925,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",-0.32149,-0.844,0.619,970,0.745,"OTX015, bromosporine, PFI.1",0.208309350979882,0.127843727251707,FALSE
+"H1299","Pearson.est","calcium channel blocker",-0.31032,-0.819,0.676,1438,0.74,"carboxyamidotriazole",0.170053304058364,0.130768280269024,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.44067,-1.16,0.271,1423,0.443,"UNBS.5162",0.567030709125594,0.35359627377693,FALSE
+"H1299","Pearson.est","CDK inhibitor",0.43316,1.13,0.311,357,0.727,"indirubin, JNJ.7706621, arcyriaflavin.a, BMS.387032, kenpaullone, alvocidib, AZD5438, P276.00, TG.02",0.507239610973163,0.138465589140962,FALSE
+"H1299","Pearson.est","CHK inhibitor",-0.54659,-1.46,0.1,1077,0.305,"LY2606368, AZD7762, PF.477736",1,0.515700160653214,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",0.3016,0.776,0.734,262,0.981,"tryptanthrin, FK.3311, phenylbutazone, FR.122047, pterostilbene, amfenac",0.134303940083929,0.0083309926200515,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",0.46511,1.21,0.232,213,0.606,"PF.4981517, morin, itraconazole",0.6345120151091,0.217527375833714,FALSE
+"H1299","Pearson.est","DNA alkylating agent",0.22143,0.555,0.941,160,1,"dacarbazine, ifosfamide",0.0264103765727431,0,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.296,-0.753,0.768,1145,0.769,"pibenzimol, primaquine, teroxirone, tirapazamine, chlorambucil, valrubicin",0.114638779968488,0.114073660198569,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",0.34063,0.881,0.577,19,0.904,"azacitidine",0.238824186844269,0.0438315695246367,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",0.47361,1.22,0.237,15,0.622,"famciclovir",0.625251653989896,0.206209615309181,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",0.28468,0.727,0.778,125,1,"altretamine, estramustine.phosphate",0.109020403010311,0,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",0.40979,1.06,0.365,305,0.73,"acetophenazine, ziprasidone, domperidone, remoxipride, oxiperomide, mesoridazine, nemonapride, sertindole",0.437707135543525,0.136677139879544,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",-0.32551,-0.83,0.621,806,0.745,"estradiol.cypionate, equol, estradiol, estrone, levonorgestrel",0.20690839982342,0.127843727251707,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.61653,-1.57,0.0707,1122,0.274,"tamoxifen, raloxifene, toremifene",1.1505805862031,0.562249437179612,FALSE
+"H1299","Pearson.est","FGFR inhibitor",-0.56745,-1.49,0.0941,1284,0.318,"nintedanib, lenvatinib, dovitinib, erdafitinib, regorafenib",1.02641037657274,0.497572880015567,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.53138,-1.4,0.154,1199,0.33,"midostaurin, TG.101348, tyrphostin.AG.1296, dovitinib, quizartinib, sorafenib, ponatinib",0.812479279163537,0.481486060122112,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",0.13267,0.337,0.998,1095,1,"hydrocortisone, flumethasone, dexamethasone.acetate, fludroxycortide, desonide, betamethasone, triamcinolone.acetonide, piretanide, fluocinolone.acetonide, difluprednate, halcinonide, clobetasol.propionate, methylprednisolone, prednisolone.hemisuccinate, ciclesonide, prednisolone, beclomethasone.dipropionate, triamcinolone, rimexolone, fluticasone.propionate, flumethasone.pivalate, fluorometholone, halobetasol.propionate, prednisolone.acetate",0.000869458712628891,0,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.42895,1.12,0.321,207,0.71,"diazooxonorleucine, kynurenic.acid, latrepirdine, JNJ.16259685",0.493494967595128,0.148741651280925,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.35816,0.915,0.543,74,0.899,"indirubin, CHIR.99021",0.265200170411153,0.0462403082667712,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",0.40705,1.03,0.402,105,0.757,"GSK1904529A",0.39577394691553,0.120904120499927,FALSE
+"H1299","Pearson.est","HCV inhibitor",-0.40467,-1.05,0.372,1268,0.517,"mericitabine, narlaprevir",0.429457060118102,0.286509456906058,FALSE
+"H1299","Pearson.est","HDAC inhibitor",0.50533,1.3,0.18,228,0.823,"tacedinaline, nexturastat.a, romidepsin, JNJ.26481585, pyroxamide, vorinostat, panobinostat, R306465",0.744727494896694,0.0846001647877302,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",0.28064,0.713,0.786,444,1,"terfenadine, ranitidine, famotidine, levocetirizine, chloropyramine, astemizole, tecastemizole, pheniramine, epinastine",0.104577453960592,0,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",-0.65924,-1.69,0.0243,1047,0.347,"simvastatin, mevastatin, fluvastatin, atorvastatin, pitavastatin",1.61439372640169,0.459670525209126,FALSE
+"H1299","Pearson.est","HSP inhibitor",-0.289,-0.738,0.786,908,0.768,"VER.49009, tanespimycin, PU.H71, BIIB021, alvespimycin, NVP.AUY922, SNX.2112, ganetespib",0.104577453960592,0.114638779968488,FALSE
+"H1299","Pearson.est","JAK inhibitor",0.25473,0.634,0.877,414,1,"CEP.33779, atiprimod, pacritinib, TG.02, LY2784544, WHI.P154",0.0570004066339595,0,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.6447,-1.63,0.042,1031,0.314,"dasatinib, vatalanib, sunitinib, telatinib, midostaurin, masitinib, lenvatinib, pazopanib, sorafenib, regorafenib",1.3767507096021,0.503070351926785,FALSE
+"H1299","Pearson.est","MDM inhibitor",0.63403,1.58,0.0462,388,0.391,"nutlin.3, CGM097, idasanutlin, RITA",1.33535802444387,0.407823242604133,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.7328,1.87,0.00388,309,0.217,"selumetinib, AS.703026, PD.0325901, cobimetinib, BIX.02188, MEK162, trametinib, PD.198306, Ro.4987655, refametinib, TAK.733, AZD8330, PD.184352",2.41116827440579,0.66354026615147,TRUE
+"H1299","Pearson.est","MET inhibitor",-0.418,-1.06,0.372,1179,0.52,"NVP.BVU972, LY2801653",0.429457060118102,0.283996656365201,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.48765,-1.25,0.219,1121,0.453,"podophyllotoxin, vinblastine, secnidazole, D.64131, cabazitaxel",0.659555885159882,0.343901797987168,FALSE
+"H1299","Pearson.est","mTOR inhibitor",0.17796,0.451,0.994,403,1,"PP242, XL388, palomid.529, torin.2, PI.103, LY303511, WAY.600, PF.05212384, AZD8055, OSI.027",0.00261361560268669,0,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",0.3885,1,0.425,393,0.787,"bindarit, betulinic.acid, parthenolide...., IKK.2.inhibitor.V, tyloxapol",0.371611069949688,0.104025267640935,FALSE
+"H1299","Pearson.est","opioid receptor agonist",0.26491,0.678,0.826,1066,0.996,"salvinorin.a, BW.180C, spiradoline, ADL5859, cebranopadol, trimebutine",0.0830199526796178,0.00174066157630127,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",0.51996,1.31,0.169,418,0.887,"SB.239063, skepinone.l, TAK.715, SB.242235, CMPD.1",0.772113295386326,0.0520763801682736,FALSE
+"H1299","Pearson.est","PARP inhibitor",0.33235,0.84,0.62,268,0.897,"PJ.34, endo.IWR.1",0.207608310501746,0.0472075569559079,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.59954,-1.55,0.0684,1003,0.272,"SU014813, CP.673451, dasatinib, vatalanib, sunitinib, telatinib, linifanib, axitinib, masitinib, crenolanib, nintedanib, lenvatinib, dovitinib, pazopanib, sorafenib, ponatinib, regorafenib",1.16494389827988,0.565431095965801,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.39818,-1,0.419,1188,0.568,"GSK2830371, CID.5458317, bis.maltolato.oxovanadium.IV.",0.377785977033705,0.245651664288981,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",0.62809,1.63,0.0528,198,0.7,"cilostamide, zardaverine, GSK256066, anagrelide",1.27736607746619,0.154901959985743,FALSE
+"H1299","Pearson.est","PI3K inhibitor",0.22054,0.579,0.939,377,1,"CH5132799, pilaralisib, alpelisib, AZD6482, PI.828, idelalisib, PI.103, LY303511, PF.05212384, TG100.115, TG.100713",0.0273344077338891,0,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.8043,-2.12,0,1159,0.0408,"GW.843682X, rigosertib, HMN.214, NMS.1286937, volasertib, GSK461364, BI.2536",Inf,1.38933983691012,TRUE
+"H1299","Pearson.est","potassium channel blocker",0.47404,1.23,0.225,261,0.683,"oleoylethanolamide, ibutilide",0.647817481888638,0.165579296318467,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",0.47777,1.22,0.264,355,0.622,"S26948, oleoylethanolamide, pterostilbene, clofibrate",0.578396073130169,0.206209615309181,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.30979,-0.8,0.716,1026,0.746,"melengestrol.acetate, levonorgestrel, nomegestrol.acetate, norethindrone, norgestrel, tanaproget",0.145086977692144,0.127261172527331,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.42417,-1.09,0.36,1341,0.521,"delanzomib",0.443697499232713,0.283162276700476,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.32809,-0.856,0.585,1024,0.749,"clofoctol, cycloheximide, homoharringtonine, bruceantin, harringtonine, puromycin, mercaptopurine, anguidine",0.23284413391782,0.125518182300534,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.44667,-1.16,0.269,1162,0.443,"AV.412, tyrphostin.A9, rheochrysidin, mubritinib",0.570247719997592,0.35359627377693,FALSE
+"H1299","Pearson.est","RAF inhibitor",-0.45206,-1.18,0.279,1193,0.479,"PLX.4720, RAF265, TAK.632, sorafenib, regorafenib",0.554395796726402,0.319664486585437,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.61639,-1.6,0.0407,1082,0.31,"sunitinib, cabozantinib, sorafenib, regorafenib",1.39040559077478,0.508638306165727,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",-0.28872,-0.753,0.741,1295,0.769,"LE.135, fenretinide",0.130181792020672,0.114073660198569,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.73811,-1.91,0.00849,1319,0.0964,"LY2334737, triapine, pentostatin, gemcitabine, clofarabine, cladribine",2.07109230975605,1.01592296609717,TRUE
+"H1299","Pearson.est","serotonin receptor agonist",0.62784,1.61,0.0506,283,0.586,"aripiprazole, ipsapirone, SR.57227A",1.2958494831602,0.232102383981909,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",0.41903,1.07,0.371,310,0.742,"aripiprazole, ziprasidone, SB.228357, sertindole, tropisetron",0.430626090384954,0.129596094720973,FALSE
+"H1299","Pearson.est","sodium channel blocker",0.33988,0.872,0.589,460,0.865,"lappaconite, benzethonium, A.803467, triamterene, ajmaline, mexiletine, butamben",0.229884705212898,0.0629838925351858,FALSE
+"H1299","Pearson.est","src inhibitor",0.33054,0.872,0.616,220,0.865,"PP.2, PP.1, saracatinib",0.210419287835575,0.0629838925351858,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.54516,-1.4,0.127,1087,0.33,"sulconazole, ketoconazole, chlormidazole, lanoconazole",0.896196279044043,0.481486060122112,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",0.60935,1.58,0.0686,219,0.391,"LY2109761, D.4476",1.16367588429325,0.407823242604133,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",0.24364,0.616,0.915,209,1,"carmofur",0.0385789059335517,0,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.73381,-1.93,0.00198,1275,0.117,"epirubicin, etoposide, licochalcone.a, SN.38, nemorubicin, teniposide, amsacrine, voreloxin, exatecan.mesylate, doxorubicin, amonafide, daunorubicin, valrubicin, etoposide.phosphate, idarubicin, TAS.103, mitoxantrone",2.70333480973847,0.931814138253838,TRUE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.63239,-1.63,0.0483,1073,0.314,"nocodazole, oxibendazole, podophyllotoxin, ABT.751, parbendazole, vincristine, CYT.997, KX2.391, vindesine, verubulin, taltobulin, vinblastine, BNC105, fenbendazole, dolastatin.10, epothilone.b, flubendazole, mebendazole, docetaxel",1.31605286924849,0.503070351926785,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",-0.44798,-1.16,0.274,1031,0.443,"dasatinib, bafetinib, sunitinib, tyrphostin.AG.99, AV.412, cabozantinib, hypericin, tyrphostin.A9, rheochrysidin, sorafenib, mubritinib, regorafenib",0.562249437179612,0.35359627377693,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.49011,-1.26,0.202,1044,0.465,"vatalanib, MK.2461, sunitinib, telatinib, cabozantinib, linifanib, axitinib, TG.100572, RAF265, nintedanib, lenvatinib, dovitinib, golvatinib, pazopanib, sorafenib, tivozanib, foretinib, regorafenib",0.694648630553376,0.332547047110046,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.51264,1.29,0.197,233,0.707,"maxacalcitol, ercalcitriol, calcitriol, paricalcitol",0.705533773838407,0.150580586203101,FALSE
+"HCC44","Pearson.est","EGFR inhibitor",0.1722,0.429,0.998,14,0.996,"GW.583340, AEE788",0.000869458712628891,0.00174066157630127,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",0.32028,0.797,0.688,400,0.904,"flumatinib, ZM.306416, bafetinib, ponatinib, bosutinib, metatinib, GZD824",0.162411561764489,0.0438315695246367,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",-0.44067,-1.13,0.31,981,0.54,"oxiracetam, nefiracetam, nicotine",0.508638306165727,0.267606240177031,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",0.66113,1.66,0.0295,287,0.464,"iododexetimide, darifenacin, diphemanil, hyoscyamine",1.53017798402184,0.333482019445119,FALSE
+"HCC44","Pearson.est","adenosine receptor antagonist",-0.33137,-0.843,0.629,1395,0.849,"PSB.1115",0.201349354554731,0.0710923097560473,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.23497,-0.589,0.927,1226,0.953,"metaraminol, clenbuterol, oxymetazoline",0.0329202658555029,0.0209070993616736,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",-0.33035,-0.848,0.63,1347,0.873,"atipamezole, levobunolol, dronedarone, imiloxan",0.200659450546418,0.0589857562944303,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.51981,-1.31,0.185,904,0.525,"palomid.529, MK.2206, AT7867, CCT128930, GDC.0068, ONC201, uprosertib",0.732828271596986,0.279840696594043,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.36815,0.951,0.488,617,0.952,"AP26113, NVP.TAE684, CEP.37440, brigatinib, lorlatinib, AZD3463, GW.788388, SB.505124, DMH1",0.311580177997289,0.0213630516155257,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",-0.47859,-1.2,0.27,1427,0.553,"RU.58841",0.568636235841013,0.257274868695302,FALSE
+"HCC44","Pearson.est","antioxidant",-0.46658,-1.21,0.242,1037,0.573,"taurine, chlorogenic.acid, benfotiamine, mesna",0.616184634019569,0.24184537803261,FALSE
+"HCC44","Pearson.est","AP inhibitor",0.32324,0.83,0.675,277,0.951,"idronoxil, embelin",0.170696227168975,0.0218194830625861,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",-0.42522,-1.11,0.34,1135,0.544,"digoxin, ouabain, thonzonium",0.468521082957745,0.26440110030182,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.63083,-1.57,0.0573,1180,0.568,"barasertib, CCT129202, ENMD.2076, hesperadin, tozasertib, alisertib, GSK1070916, MK.8745, KW.2449, PF.03814735, MLN.8054",1.24184537803261,0.245651664288981,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.45877,1.14,0.305,34,1,"josamycin, dirithromycin",0.515700160653214,0,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.47814,-1.21,0.259,1301,0.573,"trovafloxacin, novobiocin, finafloxacin",0.586700235918748,0.24184537803261,FALSE
+"HCC44","Pearson.est","BCL inhibitor",-0.37637,-0.939,0.5,1281,0.809,"venetoclax, HA14.1, oridonin",0.301029995663981,0.0920514783877277,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",0.38991,0.987,0.451,400,0.947,"flumatinib, bafetinib, ponatinib, bosutinib, metatinib, GZD824",0.345823458122039,0.0236500209967266,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.26417,-0.69,0.845,1176,0.965,"zaleplon, eprinomectin, lorazepam, CGS.20625, ivermectin",0.0731432910503077,0.0154726866562074,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",-0.3035,-0.762,0.713,1050,0.956,"OTX015, JQ1...., I.BET.762",0.146910470148134,0.0195421077238999,FALSE
+"HCC44","Pearson.est","calcium channel blocker",0.31635,0.823,0.657,162,0.909,"carboxyamidotriazole, fendiline",0.182434630440219,0.0414361167780325,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",0.36698,0.932,0.528,141,0.925,"UNBS.5162, MK.0812",0.277366077466188,0.0338582672609674,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.58614,-1.51,0.0862,1103,0.596,"P276.00, abemaciclib, indisulam, R547, TG.02, BMS.265246, indirubin, JNJ.7706621, alvocidib, palbociclib, PHA.793887, ribociclib, kenpaullone, AZD5438",1.06449273417529,0.224753740259764,FALSE
+"HCC44","Pearson.est","CHK inhibitor",0.46693,1.2,0.261,414,1,"PF.477736, LY2606368, SB.218078",0.583359492661719,0,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",0.22839,0.59,0.912,354,1,"AM.404, naproxen, tepoxalin, FK.3311, acetylsalicylsalicylic.acid, metoxibutropate, pterostilbene, phenazone",0.0400051616715838,0,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",0.43107,1.09,0.376,367,1,"metyrapone, clotrimazole, cobicistat, morin",0.424812155072339,0,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",0.19426,0.48,0.988,55,1,"dianhydrogalactitol",0.00524305541237188,0,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.28278,-0.714,0.807,1233,0.997,"carboplatin, carmustine, nimorazole, busulfan",0.0931264652779296,0.00130484168834428,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.4555,-1.17,0.276,1250,0.534,"fdcyd, decitabine, azacitidine",0.559090917934782,0.272458742971444,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.52379,-1.34,0.158,950,0.635,"famciclovir, adefovir.dipivoxil, cidofovir, trifluridine, foscarnet",0.801342913045577,0.197226274708024,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",0.32856,0.826,0.667,262,0.931,"enocitabine, estramustine.phosphate, nelarabine, azodicarbonamide, artesunate",0.175874166083451,0.0310503190186574,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.51751,-1.33,0.183,1144,0.538,"UH.232...., domperidone, remoxipride, mesoridazine, oxiperomide, clebopride, ziprasidone, acetophenazine",0.737548910269571,0.269217724333611,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",0.32984,0.838,0.654,196,0.963,"levonorgestrel, estradiol.cypionate",0.184422251675733,0.0163737128754655,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",0.81727,2.08,0,260,0.0543,"toremifene, raloxifene, fulvestrant, tamoxifen, danazol",Inf,1.26520017041115,TRUE
+"HCC44","Pearson.est","FGFR inhibitor",0.71665,1.85,0.0203,288,0.175,"lenvatinib, erdafitinib, regorafenib, AZD4547, dovitinib, orantinib, nintedanib",1.69250396208679,0.756961951313706,TRUE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.2571,-0.655,0.875,1175,0.978,"TG.02, ENMD.2076, tozasertib, tandutinib, KW.2449",0.0579919469776868,0.00966114521239857,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",0.31048,0.792,0.69,363,0.889,"deflazacort, clobetasol.propionate, fluorometholone, triamcinolone.acetonide, fluticasone.propionate, halcinonide, betamethasone, flumethasone.pivalate",0.161150909262745,0.0510982390297863,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",0.36367,0.916,0.55,119,0.927,"LY456236, CGP.37849, MTPG",0.259637310505756,0.0329202658555029,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.45757,-1.19,0.247,1391,0.535,"kenpaullone, LY2090314",0.607303046740334,0.271646217978772,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.34629,-0.886,0.572,499,0.839,"AZD3463, GW.441756, danusertib, lestaurtinib, PHA.848125, GSK1838705A, GSK1904529A",0.242603971206976,0.0762380391712997,FALSE
+"HCC44","Pearson.est","HCV inhibitor",0.24472,0.617,0.904,442,1,"embelin, PSI.7976, mericitabine",0.0438315695246367,0,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",-0.54697,-1.41,0.124,1093,0.56,"AR.42, resminostat, scriptaid, belinostat, pyroxamide, vorinostat, PCI.24781, tacedinaline, trichostatin.a, givinostat, JNJ.26481585, panobinostat, R306465, romidepsin",0.906578314837765,0.2518119729938,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",0.34051,0.872,0.588,350,0.923,"tiotidine, ebastine, chloropyramine, tecastemizole, astemizole, ICI.162846, BF2.649, nizatidine",0.230622673923862,0.0347982989740879,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",0.65861,1.65,0.0378,325,0.392,"lovastatin, mevastatin, pitavastatin",1.42250820016277,0.406713932979543,FALSE
+"HCC44","Pearson.est","HSP inhibitor",-0.548,-1.43,0.139,963,0.688,"SNX.2112, VER.49009, KW.2478, tanespimycin, ganetespib, SNX.5422, XL888, NVP.AUY922, BIIB021",0.856985199745905,0.162411561764489,FALSE
+"HCC44","Pearson.est","JAK inhibitor",0.19812,0.51,0.99,166,1,"PRT062070, ruxolitinib",0.00436480540245009,0,FALSE
+"HCC44","Pearson.est","KIT inhibitor",0.31625,0.8,0.707,167,0.924,"lenvatinib, regorafenib, pazopanib, telatinib",0.150580586203101,0.0343280287798933,FALSE
+"HCC44","Pearson.est","MDM inhibitor",-0.67651,-1.73,0.038,1178,0.319,"RITA, CGM097, nutlin.3, idasanutlin",1.42021640338319,0.496209316942819,FALSE
+"HCC44","Pearson.est","MEK inhibitor",-0.86064,-2.18,0,1397,0.0112,"PD.318088, selumetinib, PD.184352, MEK162, TAK.733, AS.703026, Ro.4987655, AZD8330, cobimetinib, trametinib, PD.0325901, refametinib",Inf,1.95078197732982,TRUE
+"HCC44","Pearson.est","MET inhibitor",0.27659,0.687,0.854,418,1,"INC.280, NVP.BVU972, LY2801653",0.068542129310995,0,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",0.37092,0.944,0.508,286,0.933,"estramustine.phosphate, colchicine, cabazitaxel, D.64131, triclabendazole",0.294136287716081,0.0301183562535,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",-0.24397,-0.621,0.879,1122,0.984,"NVP.BEZ235, torin.2, GSK2126458, LY303511, voxtalisib, PP242, XL388",0.0560111249262281,0.00700490156865849,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",0.35277,0.894,0.573,257,0.94,"tyloxapol, BAY.11.7082, bindarit, EVP4593",0.24184537803261,0.0268721464003014,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.49841,-1.27,0.202,873,0.549,"trimebutine, ADL5859, BW.180C, salvinorin.a, cebranopadol",0.694648630553376,0.260427655549908,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",0.37812,0.967,0.482,281,0.954,"VX.702, SB.242235, talmapimod",0.31695296176115,0.0204516252959049,FALSE
+"HCC44","Pearson.est","PARP inhibitor",-0.45222,-1.16,0.271,1280,0.521,"niraparib, olaparib, talazoparib",0.567030709125594,0.283162276700476,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.34502,0.881,0.572,370,0.935,"lenvatinib, regorafenib, pazopanib, telatinib, dovitinib, orantinib, nintedanib, ponatinib, masitinib",0.242603971206976,0.0291883891274822,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",0.39319,1.01,0.439,423,0.978,"BVT.948, AS.1949490, GSK2830371, CID.5458317, bis.maltolato.oxovanadium.IV.",0.357535479757879,0.00966114521239857,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.23819,-0.613,0.908,1283,0.961,"zardaverine, anagrelide",0.0419141514789149,0.0172766123314547,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",-0.28055,-0.705,0.81,1122,0.975,"NVP.BEZ235, pilaralisib, GSK2126458, alpelisib, LY303511, voxtalisib, TG.100713, CUDC.907, CH5132799",0.0915149811213502,0.0109953843014632,FALSE
+"HCC44","Pearson.est","PLK inhibitor",0.53324,1.34,0.172,271,1,"GSK461364, BI.2536, NMS.1286937",0.764471553092451,0,FALSE
+"HCC44","Pearson.est","potassium channel blocker",-0.5574,-1.42,0.115,1269,0.614,"oleoylethanolamide, ML133, meglitinide",0.939302159646388,0.211831628858832,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",0.45423,1.18,0.242,351,1,"GW.501516, fenofibrate, clofibrate, pterostilbene",0.616184634019569,0,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",0.58997,1.45,0.114,283,0.841,"nomegestrol.acetate, levonorgestrel, norgestrel, danazol, norethindrone.acetate",0.943095148663527,0.0752040042020878,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",0.25278,0.638,0.874,1084,1,"delanzomib, oprozomib, ONX.0914, carfilzomib, MG.132, ixazomib, ixazomib.citrate, bortezomib",0.058488567365597,0,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",0.44154,1.13,0.302,234,0.978,"anguidine, mercaptopurine, clindamycin.phosphate, homoharringtonine, clofoctol, puromycin, bruceantin, harringtonine",0.519993057042849,0.00966114521239857,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.3819,0.994,0.453,110,0.972,"rheochrysidin, tyrphostin.A9",0.343901797987168,0.0123337350737254,FALSE
+"HCC44","Pearson.est","RAF inhibitor",0.25403,0.646,0.885,550,1,"regorafenib, CEP.32496, PLX.4720, LGX818, TAK.632, RAF265, sorafenib, GDC.0879",0.0530567293021746,0,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.42006,1.07,0.4,522,1,"regorafenib, sorafenib, cabozantinib",0.397940008672038,0,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",0.48596,1.24,0.198,424,1,"fenretinide, AM.580, bexarotene, LE.135",0.703334809738469,0,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.53393,1.33,0.168,330,0.989,"pentostatin, LY2334737, clofarabine, gemcitabine, hydroxyurea",0.774690718274137,0.0048037084028206,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.778,-1.98,0.00411,1207,0.0582,"ipsapirone, SR.57227A, aripiprazole",2.38615817812393,1.23507701535011,TRUE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.51628,-1.33,0.164,1072,0.538,"RS.16566, tropisetron, lerisetron, pirenperone, ziprasidone, aripiprazole",0.785156151952302,0.269217724333611,FALSE
+"HCC44","Pearson.est","sodium channel blocker",0.40412,1.01,0.435,63,0.978,"oxcarbazepine, cibenzoline",0.361510743045363,0.00966114521239857,FALSE
+"HCC44","Pearson.est","src inhibitor",0.50585,1.29,0.192,396,1,"ZM.306416, TG.100572, PP.1, saracatinib, masitinib, bosutinib, KX2.391",0.71669877129645,0,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",0.72388,1.86,0.0161,313,0.243,"ketoconazole, lanoconazole, posaconazole, terconazole",1.79317412396815,0.614393726401688,TRUE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",0.44296,1.15,0.294,447,1,"adaprev, LY2109761, SB.525334",0.531652669587843,0,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.35777,-0.891,0.568,1162,0.865,"carmofur, trifluridine, raltitrexed",0.245651664288981,0.0629838925351858,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",0.21964,0.572,0.943,212,1,"dexrazoxane, mitoxantrone, licochalcone.a, etoposide",0.0254883072626717,0,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.18012,-0.455,0.988,1157,0.99,"albendazole, BNC105, verubulin, vinblastine, fosbretabulin",0.00524305541237188,0.00436480540245009,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",0.24228,0.625,0.899,134,1,"rheochrysidin, tyrphostin.A9, regorafenib",0.0462403082667712,0,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",0.40815,1.04,0.393,295,0.996,"AEE788, lenvatinib, regorafenib, pazopanib, ZM.306416, telatinib, SAR131675, dovitinib, foretinib, TG.100572, orantinib, nintedanib, cediranib",0.405607449624573,0.00174066157630127,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",0.41803,1.05,0.383,267,1,"doxercalciferol, maxacalcitol, paricalcitol",0.416801226031377,0,FALSE
+"A549","Pearson.est","EGFR inhibitor",-0.18472,-0.499,0.982,1189,1,"CNX.2006, CGP.52411, BIBU.1361, CP.724714, lapatinib, PD.168393, salvianolic.acid.B, WZ8040, WZ.4002",0.00788851221305034,0,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",-0.27754,-0.766,0.708,1399,0.865,"nilotinib, KW.2449",0.149966742310231,0.0629838925351858,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",0.35199,0.907,0.544,455,0.896,"nefiracetam, xanomeline, pilocarpine",0.26440110030182,0.0476919903378748,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",0.73994,1.89,0.0136,381,0.323,"iododexetimide, methscopolamine, diphemanil, darifenacin, hyoscyamine, dicycloverine",1.86646109162978,0.490797477668897,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.30053,0.758,0.751,264,1,"CGS.15943, MRS.1220",0.124360062995832,0,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",0.49291,1.23,0.241,466,0.968,"methyldopa, ritodrine, xylazine, clenbuterol, midodrine, metaraminol, terbutaline, oxymetazoline, A61603",0.617982957425132,0.0141246426916063,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",0.37796,0.956,0.495,354,0.911,"idazoxan, metoprolol, atenolol...., prazosin, oxprenolol, propranolol, RS.17053",0.305394801066431,0.0404816230270017,FALSE
+"A549","Pearson.est","AKT inhibitor",-0.32016,-0.864,0.602,1196,0.795,"AZD5363, A.674563, AT7867",0.220403508742175,0.0996328713435297,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.45548,1.17,0.285,440,0.874,"lorlatinib, CEP.37440, GW.788388, NVP.TAE684, DMH1, SB.505124, AP26113",0.54515513999149,0.058488567365597,FALSE
+"A549","Pearson.est","androgen receptor antagonist",0.4047,1.01,0.435,487,0.923,"enzalutamide, cyproterone.acetate, bicalutamide, flutamide",0.361510743045363,0.0347982989740879,FALSE
+"A549","Pearson.est","antioxidant",-0.46539,-1.24,0.21,1135,0.876,"trolox, mesna, chlorogenic.acid, rutin",0.677780705266081,0.0574958938319193,FALSE
+"A549","Pearson.est","AP inhibitor",0.18863,0.473,0.978,1176,1,"tanshinone.i, embelin, LCL.161, GDC.0152, birinapant, idronoxil",0.00966114521239857,0,FALSE
+"A549","Pearson.est","ATPase inhibitor",0.40472,1.02,0.415,85,0.938,"k.strophanthidin, evodiamine",0.381951903287907,0.0277971616209356,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.41061,-1.1,0.309,1201,0.689,"MK.5108, MLN.8054, GSK1070916, hesperadin, AMG900, CYC116, KW.2449, PF.03814735",0.510041520575165,0.161780778092374,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.46725,1.21,0.215,158,0.824,"josamycin, azithromycin, tilmicosin, dirithromycin",0.667561540084395,0.0840727883028842,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.48928,1.23,0.221,183,0.968,"norfloxacin, sarafloxacin, sparfloxacin",0.655607726314889,0.0141246426916063,FALSE
+"A549","Pearson.est","BCL inhibitor",-0.28603,-0.773,0.724,1238,0.887,"venetoclax, TW.37",0.140261433802853,0.0520763801682736,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.37369,0.956,0.491,318,0.911,"bafetinib, flumatinib, bosutinib, GZD824",0.308918507877032,0.0404816230270017,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",0.36781,0.954,0.502,77,0.884,"CL.218872, indiplon, gamma.aminobutyric.acid",0.299296282854981,0.0535477349869269,FALSE
+"A549","Pearson.est","bromodomain inhibitor",0.4277,1.07,0.383,370,0.991,"I.BET151, JQ1....",0.416801226031377,0.00392634551472468,FALSE
+"A549","Pearson.est","calcium channel blocker",0.33841,0.859,0.636,210,0.907,"SKF.96365, fendiline",0.196542884351586,0.0423927129399047,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",0.37094,0.956,0.504,203,0.911,"SB.225002, PF.04136309",0.297569463554475,0.0404816230270017,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.43776,-1.19,0.251,1110,0.737,"palbociclib, ribociclib, PHA.848125, R547, AZD5438, PHA.793887, NU6027, BMS.265246",0.600326278518962,0.132532512140949,FALSE
+"A549","Pearson.est","CHK inhibitor",0.30023,0.766,0.751,127,1,"PF.477736",0.124360062995832,0,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",0.32177,0.809,0.688,100,0.972,"naproxen, pterostilbene, phenylbutazone",0.162411561764489,0.0123337350737254,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",0.67378,1.73,0.0298,199,0.556,"itraconazole, morin, clotrimazole",1.52578373592374,0.254925208417942,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.44123,-1.22,0.22,1270,0.828,"carmustine, dianhydrogalactitol, cyclophosphamide, carboplatin, mitomycin.c, streptozotocin",0.657577319177794,0.0819696632151199,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.37385,-1.01,0.413,1205,0.783,"mechlorethamine, carmustine, nimorazole, teroxirone, carboplatin, valrubicin",0.384049948343599,0.106238237942057,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.4426,1.12,0.333,6,0.911,"SGI.1027",0.47755576649368,0.0404816230270017,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",0.423,1.06,0.396,618,0.923,"famciclovir, cephalomannine, foscarnet, menadione, trifluridine, cidofovir",0.402304814074488,0.0347982989740879,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.52448,-1.41,0.128,1310,0.68,"enocitabine, cyclocytidine, anisomycin, floxuridine, mitomycin.c",0.892790030352132,0.167491087293764,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",0.33172,0.871,0.612,272,0.939,"sertindole, clebopride, nemonapride, domperidone, lurasidone",0.213248577854439,0.0273344077338891,FALSE
+"A549","Pearson.est","estrogen receptor agonist",-0.42084,-1.14,0.303,1087,0.714,"ethinyl.estradiol, estradiol, levonorgestrel, PPT",0.518557371497695,0.146301788223826,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.56015,1.43,0.11,279,1,"toremifene, tamoxifen, fulvestrant",0.958607314841775,0,FALSE
+"A549","Pearson.est","FGFR inhibitor",0.53877,1.37,0.136,541,1,"orantinib, erdafitinib, lenvatinib, lucitanib, dovitinib, regorafenib, PD.173074",0.866461091629782,0,FALSE
+"A549","Pearson.est","FLT3 inhibitor",0.23949,0.614,0.905,379,0.985,"gilteritinib, tyrphostin.AG.1296, sorafenib, tandutinib, dovitinib",0.0433514207947967,0.00656376950238827,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.606,-1.65,0.0366,1177,0.547,"triamcinolone, fluticasone.propionate, prednisolone.acetate, flumethasone.pivalate, prednisolone.hemisuccinate, halobetasol.propionate, rimexolone, clobetasol.propionate, dexamethasone.acetate, methylprednisolone, beclomethasone.dipropionate, fludroxycortide, desonide, ciclesonide, prednisolone, fluocinolone.acetonide",1.43651891460559,0.262012673666569,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.341,0.867,0.6,619,0.919,"kynurenic.acid, JNJ.16259685, felbamate, diazooxonorleucine, IEM1754, LY456236, CPP, CGP.37849, tiletamine, ACDPP",0.221848749616356,0.0366844886138887,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",0.18687,0.477,0.987,485,1,"CHIR.99021, GSK.3.inhibitor.IX, CHIR.98014",0.00568284733036327,0,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",-0.40315,-1.1,0.317,1174,0.689,"PHA.848125, AZD3463",0.498940737782249,0.161780778092374,FALSE
+"A549","Pearson.est","HCV inhibitor",-0.33687,-0.884,0.553,1432,0.792,"narlaprevir",0.257274868695302,0.101274818410506,FALSE
+"A549","Pearson.est","HDAC inhibitor",-0.34015,-0.945,0.521,1069,0.786,"trichostatin.a, RG2833, PCI.24781, chidamide, mocetinostat, romidepsin, entinostat, JNJ.26481585, givinostat",0.283162276700476,0.104577453960592,FALSE
+"A549","Pearson.est","histamine receptor antagonist",0.40639,1.04,0.4,397,0.93,"chloropyramine, famotidine, lafutidine, ebastine, astemizole, tiotidine, epinastine, cyproheptadine",0.397940008672038,0.0315170514460649,FALSE
+"A549","Pearson.est","HMGCR inhibitor",-0.2362,-0.648,0.896,1114,0.965,"fluvastatin, pitavastatin",0.0476919903378748,0.0154726866562074,FALSE
+"A549","Pearson.est","HSP inhibitor",-0.44121,-1.21,0.238,1146,0.767,"SNX.2112, alvespimycin, BIIB021, NVP.AUY922, PU.H71, VER.49009, ganetespib, tanespimycin",0.623423042943488,0.115204636051019,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.31417,-0.838,0.648,1165,0.807,"TG.101209, pacritinib, WHI.P154, filgotinib, AZ960",0.188424994129407,0.0931264652779296,FALSE
+"A549","Pearson.est","KIT inhibitor",0.41322,1.06,0.374,282,0.923,"cediranib, lenvatinib, pazopanib, sorafenib, tandutinib",0.42712839779952,0.0347982989740879,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.7901,-2.13,0.00233,1438,0.0585,"idasanutlin, RITA",2.63264407897398,1.23284413391782,TRUE
+"A549","Pearson.est","MEK inhibitor",-0.51882,-1.35,0.16,1152,0.706,"PD.0325901, PD.198306, MEK162, trametinib, U.0126, nobiletin, TAK.733, AS.703026, Ro.4987655, selumetinib, AZD8330, PD.318088, refametinib, PD.184352",0.795880017344075,0.151195298948196,FALSE
+"A549","Pearson.est","MET inhibitor",-0.35853,-0.969,0.451,517,0.822,"AMG458, INC.280, NVP.BVU972, LY2801653, PHA.665752, PF.04217903",0.345823458122039,0.0851281824599496,FALSE
+"A549","Pearson.est","microtubule inhibitor",0.18599,0.47,0.986,580,0.987,"colchicine, estramustine.phosphate, triclabendazole, vinflunine",0.0061230850587888,0.00568284733036327,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.73049,-2,0.00796,1223,0.0941,"AZD2014, PI.103, WYE.354, LY3023414, XL388, AZD8055, PP242, temsirolimus, ku.0063794, deforolimus, MLN0128, torin.1, GDC.0980, GSK2126458, sirolimus, everolimus, NVP.BEZ235, SB.2343",2.09908693226233,1.02641037657274,TRUE
+"A549","Pearson.est","NFkB pathway inhibitor",0.60624,1.51,0.0748,214,1,"parthenolide...., bindarit, tyloxapol, bortezomib",1.12609840213554,0,FALSE
+"A549","Pearson.est","opioid receptor agonist",0.36449,0.907,0.574,461,0.896,"spiradoline, ADL5859, trimebutine",0.241088107602027,0.0476919903378748,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",0.58478,1.5,0.0855,291,1,"TAK.715, SB.239063, SB.242235",1.06803388527183,0,FALSE
+"A549","Pearson.est","PARP inhibitor",0.36947,0.933,0.551,339,0.899,"E7449, PJ.34, AG.14361",0.258848401148215,0.0462403082667712,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.24621,0.624,0.903,282,1,"orantinib, lenvatinib, pazopanib, sorafenib, tandutinib",0.0443122496864942,0,FALSE
+"A549","Pearson.est","phosphatase inhibitor",0.30736,0.756,0.756,413,0.987,"BVT.948, AS.1949490, alexidine, GSK2830371, CID.5458317",0.121478204498793,0.00568284733036327,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",0.27832,0.711,0.807,45,0.98,"enoximone",0.0931264652779296,0.00877392430750515,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.5417,-1.49,0.1,1241,0.625,"PI.103, pilaralisib, LY3023414, GDC.0941, taselisib, ZSTK.474, YM.201636, PI3K.IN.2, GDC.0980, GSK2126458, NVP.BEZ235, SB.2343",1,0.204119982655925,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.59319,-1.6,0.0588,894,0.508,"GSK461364, NMS.1286937, volasertib, rigosertib, HMN.214",1.23062267392386,0.294136287716081,FALSE
+"A549","Pearson.est","potassium channel blocker",0.4789,1.22,0.248,8,0.922,"dofetilide",0.605548319173784,0.0352690789463706,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.38852,0.971,0.481,130,0.981,"pterostilbene, S26948",0.317854923626168,0.0083309926200515,FALSE
+"A549","Pearson.est","progesterone receptor agonist",-0.17373,-0.485,0.995,250,0.986,"norethindrone.acetate, nomegestrol.acetate, norethindrone, dienogest, norgestrel, melengestrol.acetate, danazol, tanaproget, levonorgestrel",0.00217691925427455,0.0061230850587888,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.55627,1.41,0.118,270,1,"oprozomib, bortezomib, carfilzomib, MG.132",0.928117992693875,0,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.25549,-0.687,0.828,1235,0.949,"anguidine, cycloheximide, thiostrepton, mercaptopurine",0.0819696632151199,0.0227337875727074,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.22546,-0.607,0.919,983,0.977,"AV.412, BMS.599626, NVP.TAE226, CP.724714, mubritinib",0.0366844886138887,0.0101054362812269,FALSE
+"A549","Pearson.est","RAF inhibitor",0.49439,1.25,0.218,591,1,"GDC.0879, SB.590885, sorafenib, vemurafenib, PLX.4720, regorafenib, RAF265, TAK.632, AZ.628",0.661543506395395,0,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",0.51595,1.31,0.179,468,1,"apatinib, sorafenib, regorafenib",0.747146969020107,0,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.28966,0.729,0.775,345,1,"tamibarotene, adapalene, fenretinide, AM.580",0.11069829749369,0,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.33498,-0.888,0.57,1092,0.82,"triapine, cladribine, gemcitabine, fludarabine, clofarabine",0.244125144327509,0.0861861476162833,FALSE
+"A549","Pearson.est","serotonin receptor agonist",-0.43689,-1.18,0.239,630,0.693,"pardoprunox, NAN.190, SR.57227A, zolmitriptan, ipsapirone, aripiprazole",0.621602099051862,0.159266765388193,FALSE
+"A549","Pearson.est","serotonin receptor antagonist",0.49588,1.26,0.205,272,1,"lerisetron, sertindole, pirenperone, tropisetron, lurasidone",0.688246138944246,0,FALSE
+"A549","Pearson.est","sodium channel blocker",0.4614,1.16,0.277,459,0.851,"cibenzoline, lappaconite, triamterene, benzethonium, oxcarbazepine, quinidine, brivaracetam, mepivacaine, A.803467",0.557520230935551,0.0700704399154121,FALSE
+"A549","Pearson.est","src inhibitor",0.22815,0.563,0.951,564,1,"bosutinib, PP.1, saracatinib, ZM.306416",0.0218194830625861,0,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",0.29002,0.723,0.811,254,0.987,"chlormidazole, terconazole",0.090979145788844,0.00568284733036327,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",0.45853,1.21,0.231,475,0.824,"LY2109761, D.4476, SB.525334, repsox",0.636388020107856,0.0840727883028842,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",-0.35595,-0.953,0.466,1290,0.81,"raltitrexed, carmofur",0.33161408331,0.0915149811213502,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.39816,-1.07,0.349,1392,0.705,"mitoxantrone, idarubicin, voreloxin, valrubicin, amsacrine, TAS.103",0.45717457304082,0.151810883008601,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",0.24805,0.619,0.898,428,1,"indibulin, vinorelbine, vincristine, vindesine, paclitaxel, nocodazole, ABT.751",0.0467236633326956,0,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",0.26898,0.696,0.831,287,0.979,"rheochrysidin, tivantinib, bafetinib, apatinib, sorafenib, PP.121",0.080398976215889,0.00921730819686218,FALSE
+"A549","Pearson.est","VEGFR inhibitor",0.26694,0.674,0.836,271,0.985,"cediranib, orantinib, lenvatinib, pazopanib, SAR131675, lucitanib, sorafenib",0.0777937225609836,0.00656376950238827,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",-0.34369,-0.942,0.492,1018,0.754,"alfacalcidol, doxercalciferol, ercalcitriol, tacalcitol",0.30803489723264,0.122628654130226,FALSE
+"H1703","Pearson.est","EGFR inhibitor",0.43554,1.13,0.3,290,0.877,"tyrphostin.AG.1478, OSI.420, BIBX.1382, WZ8040, tyrphostin.AG.494, icotinib, BIBU.1361, erlotinib, gefitinib, PD.153035, CGP.52411, dacomitinib, AZD8931, canertinib, CP.724714, pelitinib",0.522878745280338,0.0570004066339595,FALSE
+"H1703","Pearson.est","Abl kinase inhibitor",0.32783,0.834,0.618,11,1,"imatinib",0.209011524911184,0,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",0.29505,0.749,0.746,115,0.954,"nefiracetam",0.127261172527331,0.0204516252959049,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.24619,-0.659,0.842,1353,0.923,"iododexetimide",0.0746879085003505,0.0347982989740879,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",0.64329,1.65,0.0287,189,1,"SCH.58261, CGS.15943, MRS.1220, PSB.1115",1.54211810326601,0,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",0.33315,0.858,0.599,187,0.993,"oxymetazoline, lidamidine, clenbuterol",0.222573177610689,0.00305075150461883,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",0.28868,0.745,0.761,168,0.897,"dronedarone, levobunolol, imiloxan, atenolol....",0.118615343229427,0.0472075569559079,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.6034,1.52,0.0716,204,1,"uprosertib, CCT128930, palomid.529, GDC.0068, triciribine, AZD5363",1.14508697769214,0,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.3049,0.778,0.722,373,0.957,"GW.788388, NVP.TAE684, SB.505124, alectinib",0.141462802430361,0.0190880622231565,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",-0.35591,-0.985,0.44,1411,0.896,"flutamide",0.356547323513813,0.0476919903378748,FALSE
+"H1703","Pearson.est","antioxidant",0.31943,0.815,0.668,507,0.993,"benfotiamine, mesna, taurine, chlorogenic.acid",0.175223537524454,0.00305075150461883,FALSE
+"H1703","Pearson.est","AP inhibitor",-0.35767,-0.949,0.486,1425,0.918,"idronoxil",0.313363730737707,0.0371573187987575,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.38901,-1.03,0.399,932,0.852,"omeprazole, digoxin, evodiamine, digitoxin, digitoxigenin, k.strophanthidin, oligomycin.a",0.399027104313252,0.0695604052332999,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",0.22973,0.583,0.932,520,0.967,"MLN.8054, barasertib, GSK1070916, ENMD.2076, tozasertib, MK.8745, barasertib.HQPA, KW.2449, PF.03814735",0.0305840876460186,0.0145735259169983,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.32888,-0.886,0.569,1178,0.898,"valnemulin, azithromycin, josamycin",0.244887733604929,0.0467236633326956,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.3204,-0.845,0.616,1206,0.849,"norfloxacin, sparfloxacin, lomefloxacin",0.210419287835575,0.0710923097560473,FALSE
+"H1703","Pearson.est","BCL inhibitor",0.3378,0.863,0.606,412,1,"oridonin, venetoclax, obatoclax, HA14.1, navitoclax",0.217527375833714,0,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.39158,0.999,0.444,11,0.986,"imatinib",0.35261702988538,0.0061230850587888,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.39246,1,0.442,441,1,"nefiracetam, lorazepam, gamma.aminobutyric.acid, ivermectin, piperazine, zaleplon, CGS.20625, eprinomectin",0.354577730650908,0,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",-0.42262,-1.19,0.217,1416,0.759,"PFI.1",0.66354026615147,0.11975822410452,FALSE
+"H1703","Pearson.est","calcium channel blocker",0.35515,0.906,0.572,388,0.986,"cinnarazine, efonidipine.monoethanolate, SKF.96365, pranidipine, SR.33805",0.242603971206976,0.0061230850587888,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.31279,-0.838,0.613,1272,0.792,"MK.0812, UNBS.5162",0.212539525481585,0.101274818410506,FALSE
+"H1703","Pearson.est","CDK inhibitor",0.42395,1.06,0.381,469,0.96,"indirubin, AZD5438, TG.02, JNJ.7706621, alvocidib, kenpaullone, P276.00, palbociclib, ribociclib, BMS.387032, PHA.793887, AT.7519, indisulam",0.419075024324381,0.0177287669604316,FALSE
+"H1703","Pearson.est","CHK inhibitor",0.23442,0.599,0.917,148,0.973,"SCH.900776",0.0376306643299789,0.0118871597316481,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",0.28823,0.748,0.769,300,0.934,"tryptanthrin, FR.122047, amfenac, phenylbutazone, aspirin",0.114073660198569,0.0296531237699066,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",0.49241,1.27,0.194,18,1,"PF.4981517, itraconazole",0.712198270069774,0,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.31615,-0.838,0.653,1143,0.792,"streptozotocin, cyclophosphamide, melphalan, mitomycin.c, dianhydrogalactitol",0.185086818724926,0.101274818410506,FALSE
+"H1703","Pearson.est","DNA inhibitor",-0.32689,-0.879,0.599,1217,0.868,"bendamustine, melphalan, valrubicin, chlorambucil, teroxirone",0.222573177610689,0.0614802748235081,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",0.47024,1.22,0.237,4,0.975,"azacitidine",0.625251653989896,0.0109953843014632,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",0.39207,1.02,0.423,59,1,"famciclovir",0.373659632624958,0,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.33168,-0.902,0.558,1133,0.967,"nelarabine, artemisinin, enocitabine, azodicarbonamide, mitomycin.c, artesunate",0.253365801062421,0.0145735259169983,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.47846,1.23,0.23,340,1,"acetophenazine, mesoridazine, domperidone, ziprasidone, UH.232...., remoxipride, oxiperomide, clebopride",0.638272163982407,0,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",-0.32986,-0.891,0.559,475,0.937,"PPT, erteberel, estrone, estradiol, ethinyl.estradiol, equol, estradiol.cypionate, levonorgestrel",0.252588192113577,0.0282604091122217,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",-0.6736,-1.82,0.00978,976,0.21,"danazol, raloxifene, fulvestrant, clomifene, toremifene",2.0096611452124,0.677780705266081,TRUE
+"H1703","Pearson.est","FGFR inhibitor",-0.29359,-0.772,0.723,1156,0.833,"nintedanib, dovitinib, regorafenib, erdafitinib",0.140861702705469,0.0793549985932124,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",0.30493,0.787,0.685,58,0.965,"sunitinib, TG.02, tandutinib",0.164309428507574,0.0154726866562074,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",-0.3922,-1.05,0.381,922,0.87,"ciclesonide, desonide, prednisolone.acetate, halcinonide, beclomethasone.dipropionate, halobetasol.propionate, triamcinolone.acetonide, triamcinolone, betamethasone, prednisolone.hemisuccinate, flumethasone.pivalate, methylprednisolone, fluticasone.propionate, fluorometholone, clobetasol.propionate, deflazacort",0.419075024324381,0.0604807473813815,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.39964,0.997,0.449,197,0.915,"diazooxonorleucine, latrepirdine, SIB.1757, kynurenic.acid",0.347753658996677,0.0385789059335517,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.46644,1.2,0.249,338,0.9,"indirubin, CHIR.99021, kenpaullone, GSK.3.inhibitor.IX, LY2090314",0.603800652904264,0.0457574905606751,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",0.27883,0.695,0.818,317,0.946,"GSK1904529A, lestaurtinib",0.087246696328677,0.0241088635982073,FALSE
+"H1703","Pearson.est","HCV inhibitor",0.53353,1.38,0.13,104,1,"PSI.7976, daclatasvir",0.886056647693163,0,FALSE
+"H1703","Pearson.est","HDAC inhibitor",0.43262,1.11,0.32,511,0.879,"tacedinaline, vorinostat, romidepsin, R306465, pyroxamide, panobinostat, JNJ.26481585, belinostat, resminostat, ACY.1215, RG2833, RGFP966, nexturastat.a, scriptaid, M.344, SB.939",0.494850021680094,0.0560111249262281,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.35363,0.922,0.55,361,0.984,"levocetirizine, ranitidine, terfenadine, chloropyramine, epinastine, lafutidine",0.259637310505756,0.00700490156865849,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.64677,-1.75,0.032,999,0.226,"simvastatin, fluvastatin, atorvastatin, mevastatin, pitavastatin",1.49485002168009,0.645891560852599,TRUE
+"H1703","Pearson.est","HSP inhibitor",0.44262,1.16,0.286,655,0.895,"guanidine, KW.2478, PU.H71, SNX.5422, BIIB021, XL888, tanespimycin, NMS.E973, NVP.AUY922, VER.49009",0.543633966870957,0.048176964684088,FALSE
+"H1703","Pearson.est","JAK inhibitor",0.31504,0.798,0.694,437,0.97,"TG.02, atiprimod, pacritinib, CEP.33779, lestaurtinib, tozasertib, filgotinib",0.158640529545145,0.0132282657337552,FALSE
+"H1703","Pearson.est","KIT inhibitor",0.51925,1.37,0.149,194,1,"imatinib, sunitinib, tandutinib, OSI.930, KI.8751",0.826813731587726,0,FALSE
+"H1703","Pearson.est","MDM inhibitor",0.43827,1.13,0.3,274,0.877,"nutlin.3, CGM097",0.522878745280338,0.0570004066339595,FALSE
+"H1703","Pearson.est","MEK inhibitor",0.68565,1.74,0.0204,239,1,"trametinib, PD.0325901, AS.703026, cobimetinib, Ro.4987655, MEK162, refametinib, BIX.02188, selumetinib, TAK.733, AZD8330, PD.184352, PD.198306",1.6903698325741,0,FALSE
+"H1703","Pearson.est","MET inhibitor",-0.56503,-1.52,0.0766,1021,0.366,"NVP.BVU972, PHA.665752, LY2801653",1.1157712303674,0.436518914605589,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.40933,-1.11,0.315,1293,0.8,"cabazitaxel, secnidazole, D.64131",0.501689446210399,0.0969100130080564,FALSE
+"H1703","Pearson.est","mTOR inhibitor",-0.14807,-0.406,0.995,970,1,"NVP.BEZ235, PKI.179, MLN0128, torin.1, WYE.125132, everolimus, ku.0063794, PF.04691502, WYE.354, deforolimus, SB.2343",0.00217691925427455,0,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",0.36507,0.94,0.512,529,0.977,"betulinic.acid, bortezomib, bindarit, IKK.2.inhibitor.V, parthenolide...., curcumin, parthenolide, Ro.106.9920",0.290730039024169,0.0101054362812269,FALSE
+"H1703","Pearson.est","opioid receptor agonist",0.52838,1.35,0.149,376,1,"salvinorin.a, BW.180C",0.826813731587726,0,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.31039,0.809,0.698,188,0.976,"CMPD.1, skepinone.l",0.156144577376839,0.0105501823333082,FALSE
+"H1703","Pearson.est","PARP inhibitor",0.32701,0.832,0.639,322,0.987,"PJ.34, talazoparib, endo.IWR.1",0.1944991418416,0.00568284733036327,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3435,0.859,0.626,463,1,"imatinib, sunitinib, tandutinib, KI.8751, SU014813, linifanib, orantinib, motesanib, axitinib, crenolanib",0.20342566678957,0,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.31427,-0.863,0.612,1074,0.857,"CID.5458317, AS.1949490, bis.maltolato.oxovanadium.IV., GSK2830371",0.213248577854439,0.0670191780768018,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",0.24047,0.629,0.899,613,0.965,"cilostamide, anagrelide, zardaverine, avanafil, GSK256066, papaverine",0.0462403082667712,0.0154726866562074,FALSE
+"H1703","Pearson.est","PI3K inhibitor",0.25553,0.667,0.872,345,0.942,"CH5132799, alpelisib, CUDC.907, TG100.115, TG.100713, idelalisib, LY303511, PF.05212384, GSK2126458",0.0594835150674328,0.0259490972071227,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.71167,-1.9,0.0214,1240,0.181,"NMS.1286937, volasertib, BI.2536, GSK461364",1.66958622665081,0.742321425130815,TRUE
+"H1703","Pearson.est","potassium channel blocker",0.47435,1.23,0.218,571,1,"oleoylethanolamide, meglitinide, ML133, ibutilide",0.661543506395395,0,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",0.4737,1.21,0.261,101,0.938,"oleoylethanolamide, S26948",0.583359492661719,0.0277971616209356,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.42577,-1.14,0.303,976,0.802,"danazol, norethindrone, melengestrol.acetate, norgestrel, levonorgestrel, nomegestrol.acetate",0.518557371497695,0.0958256317158365,FALSE
+"H1703","Pearson.est","proteasome inhibitor",0.28863,0.745,0.742,598,0.897,"ixazomib.citrate, bortezomib, ixazomib, oprozomib, carfilzomib, MG.132",0.129596094720973,0.0472075569559079,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",0.29715,0.754,0.749,172,0.97,"azomycin..2.nitroimidazole., florfenicol, tedizolid.phosphate, brefeldin.a",0.125518182300534,0.0132282657337552,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.44872,-1.19,0.245,1302,0.759,"rheochrysidin, tyrphostin.A9, mubritinib",0.610833915635468,0.11975822410452,FALSE
+"H1703","Pearson.est","RAF inhibitor",-0.27007,-0.738,0.776,1200,0.852,"RAF265, TAK.632, regorafenib, LGX818, PLX.4720",0.110138278741812,0.0695604052332999,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.45922,1.18,0.276,251,0.898,"sunitinib, apatinib",0.559090917934782,0.0467236633326956,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",-0.4763,-1.3,0.188,1196,0.68,"adapalene, LE.135, AM.580, bexarotene, fenretinide",0.72584215073632,0.167491087293764,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.6148,-1.7,0.0412,1164,0.234,"hydroxyurea, cladribine, gemcitabine, pentostatin, clofarabine, fludarabine",1.38510278396687,0.630784142589857,TRUE
+"H1703","Pearson.est","serotonin receptor agonist",0.5751,1.48,0.0995,74,1,"aripiprazole, ipsapirone",1.00217691925427,0,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",0.49259,1.24,0.23,325,1,"aripiprazole, ziprasidone, SB.228357, tropisetron",0.638272163982407,0,FALSE
+"H1703","Pearson.est","sodium channel blocker",0.38374,0.997,0.455,305,0.915,"A.803467, brivaracetam, lappaconite, benzethonium, triamterene, ajmaline",0.341988603342888,0.0385789059335517,FALSE
+"H1703","Pearson.est","src inhibitor",0.21982,0.565,0.927,346,0.961,"PP.2, PP.1",0.0329202658555029,0.0172766123314547,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.60822,-1.62,0.0522,990,0.284,"ketoconazole, sulconazole, chlormidazole, posaconazole, lanoconazole",1.28232949699774,0.546681659952962,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.54178,1.38,0.149,421,1,"LY2109761, D.4476, SB.431542, repsox",0.826813731587726,0,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",-0.2871,-0.779,0.734,414,0.855,"carmofur, raltitrexed, capecitabine, ftorafur, trifluridine, doxifluridine",0.134303940083929,0.0680338852718274,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.69392,-1.9,0.00937,1203,0.181,"daunorubicin, voreloxin, exatecan.mesylate, doxorubicin, teniposide, amonafide, etoposide, nemorubicin, TAS.103, valrubicin, idarubicin, epirubicin, licochalcone.a, etoposide.phosphate, amsacrine, mitoxantrone",2.02826040911222,0.742321425130815,TRUE
+"H1703","Pearson.est","tubulin polymerization inhibitor",-0.1455,-0.391,1,895,0.998,"vincristine, KX2.391, podophyllotoxin, BNC105, mebendazole, flubendazole, oxibendazole, dolastatin.10, ABT.751, fenbendazole, epothilone.b, CYT.997",0,0.000869458712628891,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.1923,0.499,0.973,265,0.978,"sunitinib, tivantinib, UNC2250, apatinib, CP.724714",0.0118871597316481,0.00966114521239857,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",0.26496,0.673,0.835,459,0.954,"sunitinib, MGCD.265, PD.173074, semaxanib, OSI.930, KI.8751, SU014813, linifanib, ENMD.2076, orantinib, BMS.690514, motesanib, axitinib, XL.647",0.0783135245163979,0.0204516252959049,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.35812,0.942,0.508,136,1,"calcitriol, ercalcitriol",0.294136287716081,0,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",-0.24065,-0.623,0.89,1259,1,"CNX.2006, rociletinib, CGP.52411, vandetanib, salvianolic.acid.B, erlotinib, PD.168393, GW.583340",0.0506099933550872,0,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",-0.465,-1.22,0.233,1251,0.893,"KW.2449, ponatinib, metatinib, dasatinib",0.632644078973981,0.0491485411114536,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",0.47098,1.15,0.292,634,0.662,"xanomeline, nefiracetam, pilocarpine, tremorine",0.534617148551582,0.1791420105603,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.34189,-0.924,0.55,493,0.969,"methscopolamine, dicycloverine, iododexetimide, darifenacin, hyoscyamine, diphemanil",0.259637310505756,0.0136762229492347,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",-0.41729,-1.1,0.313,1438,0.843,"theophylline",0.504455662453552,0.0741724253752577,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",-0.27624,-0.756,0.747,1298,1,"buphenine, A61603, norepinephrine",0.126679398184601,0,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",-0.17521,-0.464,0.992,1082,0.991,"naftidrofuryl, idazoxan, practolol, carvedilol, dihydroergocristine, metoprolol",0.00348832784582135,0.00392634551472468,FALSE
+"HCC15","Pearson.est","AKT inhibitor",0.65838,1.66,0.0394,116,0.414,"GDC.0068, uprosertib, AZD5363, GSK2110183",1.40450377817443,0.382999658879101,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.52861,1.31,0.171,177,0.5,"SB.505124, alectinib, DMH1, GW.788388",0.767003889607846,0.301029995663981,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.28333,-0.762,0.723,1266,1,"cyproterone.acetate, enzalutamide",0.140861702705469,0,FALSE
+"HCC15","Pearson.est","antioxidant",-0.27216,-0.73,0.781,912,1,"chlorogenic.acid, trolox, mesna, taurine, rutin",0.1073489661227,0,FALSE
+"HCC15","Pearson.est","AP inhibitor",-0.31105,-0.817,0.673,1346,0.994,"LCL.161",0.171984935776023,0.00261361560268669,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",0.56724,1.4,0.139,302,0.432,"k.strophanthidin, thonzonium, digoxin, evodiamine, omeprazole",0.856985199745905,0.364516253185088,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",0.3409,0.831,0.677,408,0.834,"aurora.a.inhibitor.i, barasertib, AMG900, tozasertib, CCT137690, SNS.314, ENMD.2076, danusertib, MK.8745, alisertib, barasertib.HQPA",0.169411331314856,0.0788339493622613,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.27313,0.673,0.871,612,0.916,"tilmicosin, tedizolid, azalomycin.b, dirithromycin",0.0599818449923368,0.0381045263321496,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.4307,1.07,0.374,500,0.723,"norfloxacin, sarafloxacin, lomefloxacin, trovafloxacin",0.42712839779952,0.140861702705469,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.36202,0.895,0.583,382,0.824,"oridonin, gossypol, HA14.1",0.234331445240986,0.0840727883028842,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.43676,-1.17,0.253,1261,0.798,"ponatinib, metatinib, dasatinib",0.596879478824182,0.0979971086492706,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.2289,0.561,0.933,53,0.947,"CL.218872",0.0301183562535,0.0236500209967266,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.59308,1.46,0.089,158,0.655,"I.BET151, JQ1...., OTX015",1.05060999335509,0.183758700008217,FALSE
+"HCC15","Pearson.est","calcium channel blocker",0.4107,1.01,0.428,443,0.777,"SR.33805, SKF.96365, tetrandrine, cinnarazine, mibefradil, efonidipine.monoethanolate",0.368556230986828,0.109578981199086,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.34343,0.839,0.644,267,0.845,"SB.225002, PF.04136309",0.191114132640188,0.0731432910503077,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.32768,0.812,0.67,192,0.818,"JNJ.7706621, AZD5438, TG.02, R547",0.173925197299174,0.087246696328677,FALSE
+"HCC15","Pearson.est","CHK inhibitor",0.47496,1.17,0.29,226,0.654,"PF.477736, SB.218078",0.537602002101044,0.184422251675733,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.22944,-0.598,0.909,1321,0.974,"suxibuzone, AM.404, indoprofen",0.0414361167780325,0.0114410431213845,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",0.49837,1.2,0.252,602,0.623,"itraconazole, morin, cobicistat, metyrapone",0.598599459218456,0.20551195334083,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",-0.40004,-1.09,0.33,1334,0.812,"streptozotocin, carboplatin, mitomycin.c, dianhydrogalactitol",0.481486060122112,0.0904439707588247,FALSE
+"HCC15","Pearson.est","DNA inhibitor",-0.34105,-0.881,0.573,1158,0.978,"bendamustine, valrubicin, nimorazole, teroxirone, mechlorethamine, tirapazamine, carboplatin",0.24184537803261,0.00966114521239857,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.57645,1.4,0.117,40,0.432,"azacitidine, SGI.1027",0.931814138253838,0.364516253185088,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.58985,1.44,0.0911,358,0.618,"trifluridine, cephalomannine, cidofovir, adefovir.dipivoxil",1.040481623027,0.209011524911184,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",-0.48544,-1.33,0.164,1125,0.908,"nelarabine, cisplatin, estramustine.phosphate, floxuridine, mitomycin.c",0.785156151952302,0.0419141514789149,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",0.40429,0.986,0.464,209,0.794,"raclopride, sertindole, clebopride, ziprasidone, mesoridazine",0.333482019445119,0.100179497572904,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.44764,-1.18,0.274,1145,0.918,"PPT, estradiol.cypionate, levonorgestrel, equol",0.562249437179612,0.0371573187987575,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",-0.2656,-0.711,0.818,383,0.951,"raloxifene, tamoxifen, toremifene, clomifene, fulvestrant, danazol",0.087246696328677,0.0218194830625861,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.61909,1.54,0.0564,344,0.519,"lucitanib, nintedanib, lenvatinib, erdafitinib, regorafenib",1.24872089601666,0.284832642151542,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.39561,0.948,0.511,400,0.809,"sorafenib, TG.02, tozasertib, tyrphostin.AG.1296, ENMD.2076, gilteritinib, tandutinib",0.291579099865287,0.0920514783877277,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.34629,-0.912,0.543,1115,0.953,"desonide, flumethasone, triamcinolone, fluticasone.propionate, methylprednisolone, rimexolone, beclomethasone.dipropionate, deflazacort, betamethasone, fluorometholone, clobetasol.propionate",0.265200170411153,0.0209070993616736,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",-0.41426,-1.08,0.357,1306,0.787,"CPP, MTPG, LY456236",0.447331783887807,0.104025267640935,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.22892,0.58,0.937,88,0.957,"CHIR.99021",0.0282604091122217,0.0190880622231565,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",-0.36599,-0.995,0.462,1288,0.891,"PHA.848125, GW.441756",0.335358024443874,0.0501222959631252,FALSE
+"HCC15","Pearson.est","HCV inhibitor",0.32878,0.813,0.694,434,0.839,"embelin, narlaprevir, daclatasvir",0.158640529545145,0.0762380391712997,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.28538,0.708,0.829,343,0.897,"RGFP966, R306465, ACY.1215, pyroxamide, belinostat, nexturastat.a, trichostatin.a, vorinostat",0.0814454694497265,0.0472075569559079,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",-0.20203,-0.538,0.976,1319,0.99,"terfenadine, zolantidine",0.0105501823333082,0.00436480540245009,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",0.49251,1.2,0.257,118,0.623,"lovastatin, atorvastatin",0.590066876668705,0.20551195334083,FALSE
+"HCC15","Pearson.est","HSP inhibitor",0.38931,0.956,0.511,333,0.823,"NMS.E973, guanidine, KW.2478, SNX.2112, BIIB021",0.291579099865287,0.0846001647877302,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.2626,0.651,0.874,495,0.918,"atiprimod, TG.02, tozasertib, AZD1480, PRT062070, AT.9283, LY2784544",0.058488567365597,0.0371573187987575,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.47071,1.14,0.324,110,0.649,"sorafenib, cediranib, OSI.930, telatinib",0.489454989793388,0.187755303199631,FALSE
+"HCC15","Pearson.est","MDM inhibitor",-0.75498,-1.96,0.00777,1329,0.325,"RITA, AMG.232, idasanutlin",2.10957898119909,0.488116639021126,FALSE
+"HCC15","Pearson.est","MEK inhibitor",-0.41137,-1.11,0.307,1101,0.878,"trametinib, PD.198306, AS.703026, PD.184352, PD.98059, nobiletin, arctigenin, U.0126, selumetinib",0.512861624522813,0.0565054840938974,FALSE
+"HCC15","Pearson.est","MET inhibitor",-0.44758,-1.17,0.266,1151,0.798,"NVP.BVU972, LY2801653, PF.04217903, PHA.665752",0.575118363368933,0.0979971086492706,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.57105,1.4,0.119,300,0.432,"vinblastine, vinflunine, podophyllotoxin, cabazitaxel, colchicine",0.924453038607469,0.364516253185088,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",-0.51208,-1.34,0.175,1093,1,"PF.04691502, LY3023414, ku.0063794, torin.1, AZD2014, WYE.125132, PI.103, sirolimus, temsirolimus, everolimus, deforolimus, MLN0128, NVP.BEZ235, SB.2343, GDC.0980",0.756961951313706,0,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.58165,1.42,0.104,365,0.528,"parthenolide...., IKK.2.inhibitor.V, bortezomib, betulinic.acid, curcumin, Ro.106.9920",0.98296666070122,0.277366077466188,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",0.37624,0.921,0.543,307,0.805,"trimebutine, salvinorin.a",0.265200170411153,0.0942041196321315,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",0.70441,1.72,0.0194,375,0.41,"TAK.715, skepinone.l, CMPD.1, SB.239063",1.71219827006977,0.387216143280265,FALSE
+"HCC15","Pearson.est","PARP inhibitor",-0.22702,-0.6,0.935,1366,1,"endo.IWR.1",0.0291883891274822,0,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.37938,0.924,0.569,242,0.827,"sorafenib, telatinib, nintedanib, crenolanib, CP.673451, lenvatinib",0.244887733604929,0.0824944904474534,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.50959,1.24,0.247,175,0.612,"alexidine, CID.5458317, mycophenolic.acid",0.607303046740334,0.213248577854439,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.40031,-1.06,0.319,1274,0.791,"YM.976, trequinsin",0.496209316942819,0.101823516502323,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",-0.30779,-0.824,0.663,1413,1,"NVP.BEZ235, SB.2343, GDC.0980, ZSTK.474",0.178486471595227,0,FALSE
+"HCC15","Pearson.est","PLK inhibitor",-0.27457,-0.72,0.762,1219,0.997,"BI.2536, GSK461364",0.1180450286604,0.00130484168834428,FALSE
+"HCC15","Pearson.est","potassium channel blocker",-0.25562,-0.69,0.836,1091,0.953,"oleoylethanolamide, meglitinide, ibutilide",0.0777937225609836,0.0209070993616736,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",0.29761,0.722,0.822,340,0.902,"S26948, pterostilbene, GW.501516",0.0851281824599496,0.0447934624580583,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.29643,-0.792,0.707,1132,1,"dienogest, danazol, norethindrone.acetate, nomegestrol.acetate, levonorgestrel",0.150580586203101,0,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.67121,1.65,0.0258,396,0.33,"MG.132, oprozomib, bortezomib, ixazomib.citrate, ixazomib, carfilzomib, delanzomib",1.58838029403677,0.481486060122112,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",-0.27266,-0.717,0.799,1247,0.971,"clofoctol, clindamycin.phosphate, anguidine, homoharringtonine, mercaptopurine",0.0974532206860086,0.0127807700919951,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.35029,0.879,0.591,298,0.825,"tyrphostin.A9, PP.121",0.228412519118745,0.0835460514500749,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.54358,1.32,0.154,114,0.515,"sorafenib, SB.590885, RAF265",0.812479279163537,0.288192770958809,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.54837,1.35,0.132,109,0.493,"sorafenib, apatinib",0.87942606879415,0.30715308072277,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",-0.47787,-1.23,0.23,1127,0.963,"adarotene, adapalene, AM.580, bexarotene, LE.135",0.638272163982407,0.0163737128754655,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.51085,-1.37,0.146,1190,1,"cladribine, hydroxyurea, gemcitabine, fludarabine, clofarabine",0.835647144215563,0,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",-0.4669,-1.25,0.259,1391,1,"NAN.190, aripiprazole",0.586700235918748,0,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",0.4239,1.03,0.415,198,0.77,"tropisetron, lerisetron, pirenperone, sertindole, ziprasidone",0.381951903287907,0.113509274827518,FALSE
+"HCC15","Pearson.est","sodium channel blocker",0.32297,0.796,0.705,133,0.821,"benzocaine, brivaracetam",0.151810883008601,0.0856568428805592,FALSE
+"HCC15","Pearson.est","src inhibitor",-0.31133,-0.828,0.653,448,1,"KX2.391, masitinib, bosutinib, ZM.306416, PP.1, PP.2, saracatinib, TG.100572, dasatinib",0.185086818724926,0,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",-0.5067,-1.34,0.158,1277,1,"ketoconazole, lanoconazole, terconazole",0.801342913045577,0,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.77391,1.91,0.00303,169,0.161,"SB.525334, LY2109761, repsox, D.4476",2.51855737149769,0.79317412396815,TRUE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",-0.50765,-1.36,0.162,1339,1,"raltitrexed, carmofur, doxifluridine",0.790484985457369,0,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",-0.36632,-0.955,0.476,1351,0.94,"nemorubicin, idarubicin, TAS.103, licochalcone.a, mitoxantrone, amsacrine",0.322393047279507,0.0268721464003014,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.58658,1.42,0.114,395,0.528,"vinorelbine, albendazole, vindesine, vinblastine, vincristine, indibulin, plinabulin, taltobulin, BNC105, podophyllotoxin, verubulin, flubendazole, docetaxel, paclitaxel, fenbendazole, mebendazole, parbendazole, fosbretabulin, nocodazole",0.943095148663527,0.277366077466188,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.35736,0.876,0.61,344,0.806,"sorafenib, tivantinib, apatinib, UNC2250, tyrphostin.A9, PP.121, regorafenib",0.214670164989233,0.0936649581949093,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.44993,1.1,0.343,344,0.695,"sorafenib, lucitanib, cediranib, OSI.930, telatinib, RAF265, nintedanib, lenvatinib, ENMD.2076, tivozanib, regorafenib",0.464705879957229,0.158015195409886,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",-0.59646,-1.56,0.0563,1171,1,"tacalcitol, ercalcitriol, paricalcitol, doxercalciferol",1.24949160514865,0,FALSE
diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/DMEA/DMEA_venn_diagram.pdf
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diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_correlation_matrix.pdf b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_correlation_matrix.pdf
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diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_dot_plot.pdf b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_dot_plot.pdf
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diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_interactive_network.graph.html b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_interactive_network.graph.html
new file mode 100644
index 0000000..82b3471
--- /dev/null
+++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-0f421471d037aba65bf0" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_mean_results.csv
new file mode 100644
index 0000000..0f0a36e
--- /dev/null
+++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_mean_results.csv
@@ -0,0 +1,187 @@
+"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"KEGG_HOMOLOGOUS_RECOMBINATION",1.17841666666667,1.02459796624054,1.69270604978669e-07,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1299, HCC44, H1703",7.8710831315081e-06
+"KEGG_DNA_REPLICATION",1.04583333333333,1.50930723622904,9.65595059085032e-10,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,6,"H2126, H460, H1299, HCC44, H1703, HCC15",1.79600680989816e-07
+"KEGG_PHENYLALANINE_METABOLISM",1.03175,1.0895522120244,3.30823591007189e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.000601866189109963
+"KEGG_MISMATCH_REPAIR",1.02908333333333,1.44272503890339,3.27271250262981e-09,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H460, HCC44, A549, H1703",2.02908175163048e-07
+"KEGG_BASE_EXCISION_REPAIR",0.97875,0.910034377472532,0.0022274807226118,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.0165724565762318
+"KEGG_PYRIMIDINE_METABOLISM",0.95825,0.732565370958301,0.0676669686243274,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.209767602735415
+"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.950333333333333,0.240004671671704,0.703990515716859,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.928588215230605
+"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.949833333333333,0.647419188826379,0.179726431611031,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.402020815583716
+"KEGG_PROTEASOME",0.916416666666667,1.11351151835765,0.00160602193985387,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.013234175660308
+"KEGG_O_GLYCAN_BIOSYNTHESIS",0.874166666666667,1.11231501696673,0.00050770044085861,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.00549278614967061
+"KEGG_SELENOAMINO_ACID_METABOLISM",0.82925,0.959435736158593,0.0233769594882975,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0820398955627046
+"KEGG_RNA_POLYMERASE",0.79125,1.13726059418715,0.00398934765303952,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0224854140444045
+"KEGG_ONE_CARBON_POOL_BY_FOLATE",0.785,1.26987823324629,2.05124549958765e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.000423924069914781
+"KEGG_PURINE_METABOLISM",0.765583333333333,0.775127022826034,0.475897605438069,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.763077194926558
+"KEGG_ETHER_LIPID_METABOLISM",0.749666666666667,0.853712250152594,0.156392207965601,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.368214565589895
+"KEGG_HISTIDINE_METABOLISM",0.743083333333333,1.12997372924678,0.00205260118811087,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0159076592078593
+"KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.731666666666667,0.928047641149108,0.0997277231660025,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.262854388753961
+"KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.726916666666667,0.865756259876388,0.194742609812029,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.416849153017455
+"KEGG_TYPE_I_DIABETES_MELLITUS",0.72075,0.878264831150812,0.899297334398398,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.999300512449779
+"KEGG_ASTHMA",0.715833333333333,1.11789378527278,0.181557787682968,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, A549",0.402020815583716
+"KEGG_CALCIUM_SIGNALING_PATHWAY",0.7085,0.426377660168669,0.998067068747268,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_OOCYTE_MEIOSIS",0.70125,1.01965048601781,0.0201743308210789,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, HCC15",0.0781755319316807
+"KEGG_TASTE_TRANSDUCTION",0.698166666666667,0.875786693969104,0.227509745426037,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.465343379227885
+"KEGG_VIRAL_MYOCARDITIS",0.678916666666667,0.50100035534978,0.976195227702956,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_TYROSINE_METABOLISM",0.66625,0.938210106823335,0.161335270586965,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.375104504114693
+"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.659083333333333,1.06095809687911,0.039631626553611,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.129324255069678
+"KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.657333333333333,1.31057304144778,0.000218908690253988,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.00271446775914945
+"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.643416666666667,1.4040944320958,0.000349743579964154,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1648, H460",0.00406576911708329
+"KEGG_SPLICEOSOME",0.63,1.1901313143744,0.00490790979738636,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H460, HCC44, H1703",0.0260820349232532
+"KEGG_ALLOGRAFT_REJECTION",0.629916666666667,1.08854978241139,0.0613083050690075,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, A549",0.193277029539583
+"KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.622083333333333,1.23359271740078,0.00117797683730166,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0104335091303861
+"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.614916666666667,1.13991231387916,0.0222912613640232,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0817110048541387
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.614916666666667,0.902022017301667,0.320447232993533,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.584344954282325
+"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.600583333333333,1.14189320136926,0.00487858307889484,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0260820349232532
+"KEGG_RNA_DEGRADATION",0.599166666666667,1.17748930381811,0.00288087918910435,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.017861450972447
+"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.597416666666667,1.1660939037763,0.0092123194793993,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.0398486377480993
+"KEGG_BETA_ALANINE_METABOLISM",0.5855,1.14213655448502,0.00919398175340353,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0398486377480993
+"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.58525,0.868972760845188,0.550513000518132,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.821401533473775
+"KEGG_LINOLEIC_ACID_METABOLISM",0.584666666666667,1.17646846987332,0.00688847961096936,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.0355904779900083
+"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.57975,1.0318027581947,0.125141087619991,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.310349897297579
+"KEGG_GLUTATHIONE_METABOLISM",0.578583333333333,1.26367512067226,0.00163648408702733,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC15",0.013234175660308
+"KEGG_AUTOIMMUNE_THYROID_DISEASE",0.578083333333333,1.10723065334056,0.0206262111610574,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.0782954137950342
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.567583333333333,1.66617283062567,6.16542804497893e-07,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H460, HCC44",2.29353923273216e-05
+"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.566,0.608545060705525,0.992102701789679,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.565,1.37543712060104,5.05275875334666e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.00072293317547883
+"KEGG_MAPK_SIGNALING_PATHWAY",0.55,0.695266855243366,0.990183545344897,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_CELL_CYCLE",0.54725,1.20601772375036,0.00737679166078348,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0361074539185718
+"KEGG_ABC_TRANSPORTERS",0.545333333333333,0.934682671803483,0.340266858187058,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.6085541886807
+"KEGG_GLYCEROLIPID_METABOLISM",0.542416666666667,0.90692532100432,0.519422800988407,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.798655854466311
+"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.53425,0.845615120381715,0.726535117270276,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.932769863334967
+"KEGG_APOPTOSIS",0.531333333333333,0.857080704095789,0.746570598950193,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.939765438870278
+"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.526,0.910660299902319,0.543721275899292,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.821401533473775
+"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.525916666666667,0.982801881295914,0.252634710542813,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.494632170115402
+"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.517,0.748066477357096,0.919293136233065,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_REGULATION_OF_AUTOPHAGY",0.51525,0.962336467807766,0.307795259062343,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.572499181855958
+"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.508,1.22398930476611,0.00844732992819473,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0383220333327859
+"KEGG_SULFUR_METABOLISM",0.503916666666667,1.43964139842553,0.00323329304440707,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, HCC44, HCC15",0.0193997582664424
+"KEGG_PYRUVATE_METABOLISM",0.503,1.1945361214524,0.0170638727671102,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.0705306741040557
+"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.497166666666667,0.719836702862447,0.992993154619186,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_ARACHIDONIC_ACID_METABOLISM",0.494833333333333,1.26928482607213,0.00243682634152823,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC15",0.0167870259083056
+"KEGG_LYSINE_DEGRADATION",0.455666666666667,1.08075834767103,0.102109871023973,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.263783833478597
+"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.450583333333333,1.05908824066513,0.216871461342754,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.458387406929003
+"KEGG_RIBOFLAVIN_METABOLISM",0.438,1.29916819542352,0.00357637473268124,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.0207876781337097
+"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.4375,1.5241159881894,3.29618288228717e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.000102181669350902
+"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.42975,1.07053454150039,0.14432287065834,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.348624077174692
+"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.412916666666667,0.956986696813904,0.552017159592591,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.821401533473775
+"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.392583333333333,1.07797971462895,0.242776373853048,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.480387292943265
+"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.392083333333333,1.00736374746016,0.516534340228838,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.798655854466311
+"KEGG_GALACTOSE_METABOLISM",0.382333333333333,1.15621823461689,0.0743950791726998,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.219642614700352
+"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.369333333333333,0.967518412635066,0.62202506242232,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.88318062298131
+"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.368,1.27398587119324,0.0959905523004081,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, A549",0.262562393056999
+"KEGG_SMALL_CELL_LUNG_CANCER",0.3625,0.865672360863876,0.933870619762417,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.361,0.99768477441069,0.519555690271095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.798655854466311
+"KEGG_ALZHEIMERS_DISEASE",0.360416666666667,0.927286898658793,0.686561731326467,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.924130465463438
+"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.358,1.33540548830002,0.0335335443815908,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.113404350090471
+"KEGG_FATTY_ACID_METABOLISM",0.355,1.02581205083405,0.387362973771825,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.661004707537243
+"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.34825,0.742362705396517,0.999300512449779,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.347083333333333,0.934868533133095,0.727159302062205,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.932769863334967
+"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.341916666666667,0.908748936058733,0.88101399080801,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_NITROGEN_METABOLISM",0.335,1.20457272696399,0.035536345952582,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.118031434771076
+"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.334083333333333,0.942384447542348,0.67917774324564,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438
+"KEGG_LONG_TERM_DEPRESSION",0.325916666666667,0.818521556147905,0.990581859975474,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.32,1.82286986520008,2.1106929698738e-09,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"H1648, H460, HCC44, A549, HCC15",1.96294446198263e-07
+"KEGG_OLFACTORY_TRANSDUCTION",0.31525,0.868470245996844,0.964401404432903,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_MTOR_SIGNALING_PATHWAY",0.3115,1.10667228457866,0.185842388347715,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.406666873325588
+"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.309083333333333,0.793703798464496,0.996749115490075,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30625,0.843936676319002,0.98661083335621,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.30275,1.02380112814941,0.539363245224781,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.821401533473775
+"KEGG_HUNTINGTONS_DISEASE",0.298583333333333,1.04824966303863,0.349386146149359,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.618912601750292
+"KEGG_INSULIN_SIGNALING_PATHWAY",0.295916666666667,0.958802990317836,0.783512539029393,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.958771922759652
+"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.292666666666667,1.1016761059514,0.232092287064376,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.465343379227885
+"KEGG_WNT_SIGNALING_PATHWAY",0.291416666666667,0.93719227272775,0.868250406632244,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_BUTANOATE_METABOLISM",0.289333333333333,1.14984373114811,0.100336890330813,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.262854388753961
+"KEGG_PARKINSONS_DISEASE",0.28925,1.11339775829746,0.219980396195696,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.459734311150556
+"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.286833333333333,1.1508898401856,0.0911817114033164,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.253131318224132
+"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.284,1.06428191753877,0.399416448291906,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.675376903475405
+"KEGG_RETINOL_METABOLISM",0.283583333333333,1.0130498918283,0.501134746761155,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.789924261843855
+"KEGG_TIGHT_JUNCTION",0.279416666666667,0.856684460668871,0.978503721117808,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_N_GLYCAN_BIOSYNTHESIS",0.279083333333333,1.07077325146859,0.364515100332333,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.633643071605738
+"KEGG_PRIMARY_IMMUNODEFICIENCY",0.27525,1.06285559824807,0.335140683722439,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.6052055065279
+"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.274333333333333,1.29016181742893,0.0892775011125904,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"A549, HCC15",0.251600230408209
+"KEGG_LEISHMANIA_INFECTION",0.25725,1.07313585728081,0.320255317745033,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.584344954282325
+"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.253916666666667,1.31526502399073,0.00709531772099448,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.035668353948783
+"KEGG_PRION_DISEASES",0.250583333333333,0.97164129729343,0.792958706376644,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.963989015595136
+"KEGG_OXIDATIVE_PHOSPHORYLATION",0.24325,1.10323269819365,0.174363446184086,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.395507329149268
+"KEGG_LONG_TERM_POTENTIATION",0.243,1.00158537964932,0.666015483885738,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438
+"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.23975,1.00041374395343,0.745563608731219,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.939765438870278
+"KEGG_CELL_ADHESION_MOLECULES_CAMS",0.237083333333333,0.878056889680362,0.976677458215597,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_PATHWAYS_IN_CANCER",0.231666666666667,0.833507303052843,0.99481558419435,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_PEROXISOME",0.221666666666667,1.03962058930024,0.480379407031576,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.763680082973274
+"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.211583333333333,1.36698017930256,0.00101529519119464,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.00944224527811017
+"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.20975,0.935412512307708,0.895263647419931,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_SPHINGOLIPID_METABOLISM",0.205416666666667,1.00677337508889,0.67737751260145,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438
+"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.197,0.928697132350673,0.94323304466941,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_TYPE_II_DIABETES_MELLITUS",0.196833333333333,1.11246440869183,0.294953618164136,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.554155282611406
+"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.195583333333333,0.967637277865602,0.777795656358136,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.95807941776565
+"KEGG_STARCH_AND_SUCROSE_METABOLISM",0.1955,0.914801766902137,0.936057504039486,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.193,1.43012866554027,0.0225532897991842,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, A549",0.0817110048541387
+"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.191,1.29111720473535,0.0177229605145894,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0716624055589921
+"KEGG_TRYPTOPHAN_METABOLISM",0.188916666666667,1.14059382128412,0.194977829637197,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.416849153017455
+"KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.169916666666667,0.828292049760813,0.996792484249936,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.168333333333333,1.3739067279003,0.00235107954118973,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.0167870259083056
+"KEGG_NON_HOMOLOGOUS_END_JOINING",0.161833333333333,1.47288472876951,0.000828899422244196,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC44, H1703, HCC15",0.00811448908091687
+"KEGG_PROPANOATE_METABOLISM",0.156666666666667,1.36364707066504,0.00254033960423149,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H460, HCC44",0.016875113085252
+"KEGG_FOLATE_BIOSYNTHESIS",0.155,1.40036034323637,0.000531559949968124,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1648",0.00549278614967061
+"KEGG_VEGF_SIGNALING_PATHWAY",0.153333333333333,1.00617921170168,0.752822851568126,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.939765438870278
+"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.148666666666667,0.962837221523719,0.915293825739356,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_ENDOCYTOSIS",0.146666666666667,1.01680912067054,0.690613627416225,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438
+"KEGG_GNRH_SIGNALING_PATHWAY",0.138916666666667,1.01080566051706,0.759439485033165,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.941704961441125
+"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.137083333333333,1.00319647838418,0.681588329910571,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438
+"KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.129166666666667,1.03823625208886,0.614324427628094,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.878956488760196
+"KEGG_TGF_BETA_SIGNALING_PATHWAY",0.128833333333333,0.94452391406593,0.926832110514637,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_P53_SIGNALING_PATHWAY",0.123,1.03048223486076,0.638724963615894,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.900021539640577
+"KEGG_GAP_JUNCTION",0.115,0.932259425462482,0.945043046567905,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_COLORECTAL_CANCER",0.10775,1.04956667465457,0.60015454373743,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.874900537969625
+"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.104916666666667,1.27172892039526,0.0281564662340232,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0969833836949688
+"KEGG_PPAR_SIGNALING_PATHWAY",0.100666666666667,0.9703464548419,0.903591358900175,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_ACUTE_MYELOID_LEUKEMIA",0.0939166666666666,1.18172873816543,0.134645570324975,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.329527316847966
+"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.0928333333333333,1.2215119419156,0.0714238160194078,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.217784094747702
+"KEGG_ERBB_SIGNALING_PATHWAY",0.0920833333333333,1.00924971757452,0.752375663603325,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.939765438870278
+"KEGG_PROTEIN_EXPORT",0.0846666666666667,1.36836414168248,0.00275159868338527,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0176481846589538
+"KEGG_FOCAL_ADHESION",0.0765833333333333,0.889728299521655,0.981798663956214,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_GLIOMA",0.0745833333333333,1.01387111054013,0.71213922581833,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.928588215230605
+"KEGG_NOTCH_SIGNALING_PATHWAY",0.06625,1.15986418679869,0.165237088395876,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.379433314094234
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.0652499999999999,1.24421849330851,0.0483770790215612,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.155140287896731
+"KEGG_PROSTATE_CANCER",0.0650833333333333,0.992098827402458,0.83561504777035,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.0495833333333333,1.04463977769924,0.613040633244817,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.878956488760196
+"KEGG_BASAL_CELL_CARCINOMA",0.046,1.05109605131544,0.598023073368012,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.874900537969625
+"KEGG_RENAL_CELL_CARCINOMA",0.0423333333333334,1.12430482224943,0.273796515491987,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.519654611035812
+"KEGG_MELANOGENESIS",0.0418333333333333,0.949206446874376,0.934485076805329,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_MELANOMA",0.038,1.05158296262003,0.602082090645763,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.874900537969625
+"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.0368333333333334,0.972080602095164,0.868846690864909,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.0355833333333333,1.01756460222286,0.698631085118344,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.928181298800086
+"KEGG_BASAL_TRANSCRIPTION_FACTORS",0.01725,1.30623658757794,0.0079845552802157,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.037128182053003
+"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.0136666666666667,0.961226142471009,0.930447980678764,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_CHRONIC_MYELOID_LEUKEMIA",0.0135,1.09460607277022,0.446921019061143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.742208120940827
+"KEGG_VIBRIO_CHOLERAE_INFECTION",0.00625000000000001,1.09782173788909,0.3714205172197,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.639668668545038
+"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.00383333333333334,0.965722417612218,0.858505892522519,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_LYSOSOME",0.00383333333333332,1.20427457102782,0.0887313049103693,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.251600230408209
+"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.00149999999999991,1.42894662410653,0.00947614990492257,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"HCC44, HCC15",0.0400582700526272
+"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.0261666666666667,1.03044719624172,0.66964869629339,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.924130465463438
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.0454166666666666,1.21223943467027,0.113400165358479,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.285032848063203
+"KEGG_PANCREATIC_CANCER",-0.0469166666666666,1.08541717646705,0.467025189737185,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.762967432947268
+"KEGG_DILATED_CARDIOMYOPATHY",-0.0538333333333333,0.913750894374226,0.958308320636934,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999300512449779
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.0665833333333333,1.22793762488412,0.269941085801347,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.517618989268562
+"KEGG_ENDOMETRIAL_CANCER",-0.07325,1.12364909800816,0.259900637390178,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50355748494347
+"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.09375,1.02224726816594,0.713914595580519,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.928588215230605
+"KEGG_THYROID_CANCER",-0.11,1.20126630156378,0.0764071889736128,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.222058392954562
+"KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.12625,1.19455142779052,0.0734459642384711,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.219642614700352
+"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.1325,1.17375988716912,0.0998239690769561,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.262854388753961
+"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.141333333333333,1.06289042737531,0.469839139209407,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.762967432947268
+"KEGG_ECM_RECEPTOR_INTERACTION",-0.151583333333333,1.08918154913205,0.471727176284601,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.762967432947268
+"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.162833333333333,1.3948842137242,0.019146091570016,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1648, HCC44",0.0757696389792124
+"KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.168166666666667,1.08230526976898,0.446526121939017,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.742208120940827
+"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.208666666666667,1.27680882980922,0.00780760920330105,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.037128182053003
+"KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.214833333333333,1.42326786805662,0.022843936840942,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.0817110048541387
+"KEGG_ADHERENS_JUNCTION",-0.220166666666667,1.12923174474212,0.232671689613943,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.465343379227885
+"KEGG_OTHER_GLYCAN_DEGRADATION",-0.250416666666667,1.51114931927706,3.55942369903741e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.000601866189109963
+"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.287583333333333,1.09291091363913,0.229371436831135,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC44",0.465343379227885
+"KEGG_AXON_GUIDANCE",-0.321416666666667,1.05206804639359,0.362417574790632,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.633643071605738
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.324916666666667,1.43695558597356,6.4587083490176e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.000858085537798053
+"KEGG_STEROID_BIOSYNTHESIS",-0.343583333333333,1.4671866373396,4.01370354133448e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1299, HCC44",0.000622124048906844
+"KEGG_RIBOSOME",-0.447833333333333,1.43659729495735,0.111402195168252,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, H460",0.283846689058835
+"KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.546833333333333,1.4700173056083,1.60584663960682e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.000373359343708586
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.579583333333333,1.51624005405317,5.56198202689802e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.00014778980814329
+"KEGG_BLADDER_CANCER",-0.590916666666667,1.02982579800781,0.147445602286902,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.351601051607228
diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..12f3d9f
--- /dev/null
+++ b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_results.csv
@@ -0,0 +1,2233 @@
+"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H1650","Input","KEGG_ABC_TRANSPORTERS",0.21787,0.634,0.956,3673,1,"ABCG2, ABCA5, ABCB8, ABCC1, TAP2, ABCA12, ABCB9, ABCB11, ABCC6",0.0195421077238999,0,FALSE
+"H1650","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.25175,0.731,0.869,4849,1,"TCF7L1, MAP2K1, AKT2, STAT3, JUP, MTOR, TCF7L2, MAPK3, PIK3R3, RUNX1, AKT3, BAD, RAF1, SOS1, CCNA1, GRB2",0.0609802235513335,0,FALSE
+"H1650","Input","KEGG_ADHERENS_JUNCTION",0.41444,1.22,0.174,5643,0.972,"TCF7L1, CDH1, SNAI1, CTNND1, ACTB, CSNK2A2, TJP1, ACTN4, RAC1, BAIAP2, SMAD2, NECTIN4, TGFBR2, PARD3, ERBB2, PTPN1, TCF7L2, AFDN, CTNNA1, NECTIN1, EGFR, PTPRJ, MAPK3, PTPRM, ACP1, EP300, SSX2IP, PTPRF, PTPN6, RHOA, NECTIN2, MET, CDC42, IQGAP1, ACTN1",0.7594507517174,0.0123337350737254,FALSE
+"H1650","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.2253,-0.81,0.747,17522,0.896,"IRS2, PCK2, PRKCQ, PRKAG1, PRKAA2, PPARGC1A, RXRB, LEPR, IRS1, NFKBIE, CAMKK1, IKBKB",0.126679398184601,0.0476919903378748,FALSE
+"H1650","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.31265,0.925,0.569,2867,0.958,"GLS, ABAT, GOT2, GAD1, GPT2, GFPT1",0.244887733604929,0.0186344909214556,FALSE
+"H1650","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.25839,-0.961,0.482,14636,0.904,"FXYD4, KCNJ1, KRAS, PIK3CG, ATP1B2, PIK3R1, IGF1, FXYD2, PIK3CD, PRKCG, HSD11B1, IRS2, SGK1, NR3C2, IRS1, SLC9A3R2, INSR",0.31695296176115,0.0438315695246367,FALSE
+"H1650","Input","KEGG_ALLOGRAFT_REJECTION",0.40437,1.17,0.231,2640,1,"CD40, IL12A, IL12B",0.636388020107856,0,FALSE
+"H1650","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.34113,0.991,0.468,1909,0.984,"PLA2G12A, ACOX1, PLA2G4B",0.329754146925876,0.00700490156865849,FALSE
+"H1650","Input","KEGG_ALZHEIMERS_DISEASE",0.29454,0.861,0.688,4938,0.973,"CHP1, NDUFAB1, UQCRC2, CALM3, PPP3R1, PSENEN, CACNA1D, CYCS, PPP3CA, CYC1, CAPN1, UQCRFS1, NAE1, BID, GAPDH, MME, GNAQ, CASP7, NDUFS6, APP, NDUFB8, COX6B1, ADAM10, EIF2AK3, MAPK3, UQCR10, CASP8, NDUFA8, GRIN2A, SDHA, ITPR2, NDUFB1, BAD, NDUFV2, CALML6, COX6C, SDHB, NDUFB3, NDUFB9, CALM1, COX8A, NDUFB6, NDUFB7",0.162411561764489,0.0118871597316481,FALSE
+"H1650","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29986,-1.15,0.236,16497,0.749,"AARS2, MARS2, TARS2, CARS2, PARS2, FARS2, WARS2",0.627087997029893,0.125518182300534,FALSE
+"H1650","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.34794,1.01,0.446,6162,0.999,"NAGK, UGP2, PGM1, GPI, GFPT1, GNE, NANP, GALT, GMPPB, GMPPA, HK2, HK1, PMM2, FPGT, HEXA, NPL, UAP1, UXS1, CYB5R3, GFPT2, PGM2",0.350665141287858,0.000434511774017692,FALSE
+"H1650","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.3911,1.13,0.265,5709,1,"CHP1, MAP3K5, PPP3R1, MAPK11, TOMM40, CYCS, PPP3CA, BID, RAC1, MAPK13, DERL1, GRIN2A, BCL2L1, BAD, CASP1, MAP2K3, SOD1, GPX1, RAB5A, NEFH, CCS",0.576754126063192,0,FALSE
+"H1650","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.25511,0.744,0.861,3229,1,"IFNA5, HSPA2, NFYC, IFI30, HSPA4, TAP2, HSPA1A, TAPBP, HSPA1B, NFYB",0.0649968485463452,0,FALSE
+"H1650","Input","KEGG_APOPTOSIS",0.34533,0.992,0.474,4883,0.994,"CHP1, PPP3R1, TRADD, ENDOD1, CYCS, PPP3CA, NGF, CAPN1, MAP3K14, BID, ENDOG, AKT2, CASP7, MYD88, IL1R1, PRKACG, IL1RAP, PRKAR1B, CASP8, PIK3R3, PRKACA, AKT3, BCL2L1, BAD, CFLAR, DFFA, PRKAR2A, EXOG",0.324221658325915,0.00261361560268669,FALSE
+"H1650","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.20615,0.605,0.979,2208,0.998,"PTGES, CYP2E1, CYP4F3, PLA2G12A, PLA2G4B, GPX7",0.00921730819686218,0.000869458712628891,FALSE
+"H1650","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.23496,-0.911,0.623,17420,0.808,"ARG2, ALDH1B1, NAGS, GLUD2, ALDH2, PRODH, CPS1, ODC1, GLS2, ACY1, MAOA, AMD1",0.20551195334083,0.0925886392254138,FALSE
+"H1650","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.39501,1.16,0.236,2136,1,"TCF7L1, ITGA4, DAG1, CACNA1D, CACNG4, ITGA1, DSC2, SLC8A1, ITGA6, ACTB, ITGB8, DSG2, JUP, PKP2, DSP, ACTN4",0.627087997029893,0,FALSE
+"H1650","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.27217,-1.02,0.409,16230,0.845,"MIOX, UGT2B7, ALDH1B1, ALDH2, UGDH",0.388276691992658,0.0731432910503077,FALSE
+"H1650","Input","KEGG_ASTHMA",-0.29495,-1.07,0.317,13707,0.771,"IL4, IL13, PRG2, IL10, FCER1G, EPX, RNASE3, IL5, TNF",0.498940737782249,0.112945621949043,FALSE
+"H1650","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.31921,0.94,0.561,1349,0.978,"IFNA5, CD40",0.251037138743839,0.00966114521239857,FALSE
+"H1650","Input","KEGG_AXON_GUIDANCE",0.37843,1.11,0.298,5824,1,"CHP1, NTN1, SEMA3E, SEMA3D, PAK4, PPP3R1, RHOD, PPP3CA, NTN4, PTK2, SEMA5A, NFAT5, SRGAP2, EFNA5, LIMK2, RAC1, SRGAP1, NFATC1, PLXNA2, ROBO3, PLXNB1, SEMA3F, SEMA4F, EFNA1, RASA1, PAK6, NFATC3, MAPK3, SEMA7A, SLIT3, EPHB3, PLXNB2, ROBO1, EPHA1, GNAI1, SEMA6B, ITGB1, EPHB4, RHOA, EPHA2, ABLIM1, MET, UNC5C, CFL2, PAK2, EFNA2, ROCK1, UNC5B, UNC5A, CDC42, SEMA3C, SEMA4B, CFL1, LIMK1, CDK5, NCK2",0.525783735923745,0,FALSE
+"H1650","Input","KEGG_BASAL_CELL_CARCINOMA",0.25186,0.73,0.879,3854,0.993,"TCF7L1, WNT9A, GLI3, WNT7B, WNT7A, WNT6, FZD6, TCF7L2, FZD9, FZD2",0.0560111249262281,0.00305075150461883,FALSE
+"H1650","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.33366,-1.19,0.212,18005,0.926,"GTF2F2, STON1, GTF2F1, GTF2H1, TBPL1, GTF2H2",0.673664139071249,0.0333890133180656,FALSE
+"H1650","Input","KEGG_BASE_EXCISION_REPAIR",0.27924,0.819,0.754,6434,0.986,"XRCC1, POLE4, POLD1, NEIL3, SMUG1, LIG1, POLE, TDG, POLD2, PARP3, APEX2, MBD4, UNG, POLD3, LIG3",0.122628654130226,0.0061230850587888,FALSE
+"H1650","Input","KEGG_BETA_ALANINE_METABOLISM",0.38435,1.1,0.312,6187,1,"ABAT, GAD1, SMS, ECHS1, UPB1, SRM, HADHA, DPYD, ALDH3A2, ALDH9A1",0.505845405981557,0,FALSE
+"H1650","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.54217,1.56,0.036,5019,0.883,"ACOT4, SCD5, HACD2, ACAA1, TECR, ACOX1, HACD1, ELOVL6, HADHA, ACOT2, YOD1, ACOT1",1.44369749923271,0.0540392964224314,FALSE
+"H1650","Input","KEGG_BLADDER_CANCER",0.29146,0.844,0.718,4165,0.977,"E2F1, CDH1, MAP2K1, TYMP, DAPK2, ERBB2, EGF, DAPK1, EGFR, MAPK3, RAF1, CDKN1A",0.1438755557577,0.0101054362812269,FALSE
+"H1650","Input","KEGG_BUTANOATE_METABOLISM",0.32002,0.935,0.559,7337,0.971,"ABAT, ACSM1, GAD1, ECHS1, HADHA, OXCT1, ACSM4, HMGCS1, ALDH3A2, PDHA1, ACAT2, AACS, ALDH9A1, PDHB, OXCT2, ALDH5A1, HADH",0.252588192113577,0.0127807700919951,FALSE
+"H1650","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35091,1.02,0.443,4157,1,"CHP1, PPP3R1, MAP2K1, PPP3CA, VAV3, PLCG2, NFAT5, DAPP1, LILRB3, AKT2, MALT1, RAC1, VAV1, NFATC1, NFKBIB, NFATC3, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1",0.35359627377693,0,FALSE
+"H1650","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.31627,0.916,0.597,4692,0.954,"ADORA2A, TNNC1, CHP1, CAMK2G, PLCD1, PLCE1, CALM3, GNAS, PPP3R1, CACNA1D, PPP3CA, P2RX2, PLCG2, SLC8A1, PHKB, RYR1, ADRA1B, SPHK2, PHKG2, GNAQ, P2RX5, OXTR, CAMK2D, PRKACG, HTR6, ADCY1, MYLK2, ERBB2, P2RX4, ADCY7, GNA15, PTK2B, ADRB1, EGFR, ADORA2B, PRKACA, GRIN2A, ITPR2, CALML6, PHKG1, TBXA2R, TRPC1, PLCD3, PTAFR, CALM1",0.224025668870631,0.0204516252959049,FALSE
+"H1650","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.31587,0.919,0.596,5320,0.965,"TNNC1, UQCRC2, CACNA1D, CACNG4, CYC1, SLC8A1, TNNI3, UQCRFS1, SLC9A1, TPM2, TPM1, COX6B1, UQCR10, CACNA2D2, COX6C, CACNB1, MYL3, COX8A, TNNT2, CACNG1, ATP1B1",0.224753740259764,0.0154726866562074,FALSE
+"H1650","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.30497,0.893,0.642,2668,0.949,"ITGA4, GLG1, CDH3, ITGB2, CDH1, PVR, SDC4, NFASC, SDC1, CD226, ITGA6, CD40, ITGB8, F11R, OCLN, CLDN7, CLDN23, CLDN4, SDC2",0.192464971931147,0.0227337875727074,FALSE
+"H1650","Input","KEGG_CELL_CYCLE",0.28974,0.842,0.711,8040,0.964,"E2F1, YWHAZ, PLK1, RBL2, E2F4, RAD21, ORC6, YWHAB, CHEK2, CCNE1, SFN, PKMYT1, ANAPC2, SMAD2, CCND3, ANAPC10, CDC23, CHEK1, SMC1B, RBL1, SKP2, RBX1, ANAPC7, CDKN1A, CCNB1, MAD1L1, CDC25A, CDC25B, EP300, CDKN2D, CCNE2, CCNA1, CDC20, CCNA2, HDAC1, CDC6, MCM5, YWHAE, BUB1, MAD2L2, ZBTB17, CUL1, CDC14A, PRKDC, YWHAQ, ESPL1, CDC45, CDK7, WEE2, TGFB3, CDK2, CDC7, MCM6, GADD45A, ORC3, E2F2, SMAD4, TGFB2, BUB1B, CCNB2, MAD2L1, MCM4, CREBBP, CDC14B, TGFB1, DBF4, GADD45B, ORC1, PTTG1, YWHAG, CCNH, CDKN1B, ABL1, YWHAH",0.148130399270234,0.0159229660971692,FALSE
+"H1650","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.328,0.96,0.507,4238,0.973,"CCR3, CCR2, CCL5, CCL28, STAT1, BCAR1, GNG13, MAP2K1, VAV3, STAT2, PRKCD, PTK2, RAP1A, GSK3A, PXN, GRK3, AKT2, STAT3, TIAM1, CXCR1, RAC1, VAV1, CCR1, PRKACG, ADCY1, PARD3, NFKBIB, ADCY7, CXCL16, PTK2B, VAV2, MAPK3, PIK3R3, CCR5, PRKACA, CCL17, AKT3, PRKCZ, CCR4, RAF1, GNG10, SOS1, TIAM2",0.294992040666664,0.0118871597316481,FALSE
+"H1650","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.21409,-0.783,0.762,17589,0.915,"SHC3, STAT5B, MYC, CDK4, SHC2, RB1, TP53, CDKN2A, GAB2, HDAC2, MECOM, IKBKB",0.1180450286604,0.0385789059335517,FALSE
+"H1650","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.44307,-1.66,0.058,15827,0.35,"PER2, BHLHE41, ARNTL, NPAS2",1.23657200643706,0.455931955649724,FALSE
+"H1650","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.44968,1.32,0.0991,6590,1,"PC, MDH1, OGDH, ACO2, IDH3B, SDHA, SUCLG1, MDH2, SDHB, IDH2, IDH3A, PDHA1, IDH1, PDHB, SDHC",1.00392634551472,0,FALSE
+"H1650","Input","KEGG_COLORECTAL_CANCER",0.26134,0.765,0.841,3976,0.999,"TCF7L1, MAP2K1, CYCS, AKT2, RAC1, SMAD2, TGFBR2, TCF7L2, MAPK3, PIK3R3, AKT3, BAD, RAF1",0.0752040042020878,0.000434511774017692,FALSE
+"H1650","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.34221,-1.3,0.146,13893,0.711,"FGA, SERPIND1, F7, CPB2, FGB, F2, SERPING1, F13A1, C6, F5, C4BPA, C7, CR2, MASP1, C1S, THBD, SERPINF2, C4B, PLG, F10, VWF, F2R, C4A, A2M, KLKB1, SERPINA5, MASP2, C3AR1, BDKRB1, C1R, PROS1, CFH, BDKRB2, C2, SERPINE1, PLAT",0.835647144215563,0.148130399270234,FALSE
+"H1650","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.27313,0.789,0.798,4360,0.985,"LDHAL6B, GOT2, SMS, ADI1, TAT, AHCYL2, AHCY, CBS, SRM, DNMT1, DNMT3B, ENOPH1",0.0979971086492706,0.00656376950238827,FALSE
+"H1650","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.27248,0.793,0.794,3741,0.986,"CCR3, IFNL1, CCR2, IFNL3, CCL5, CSF1R, IL20RB, IFNA5, CCL28, PDGFB, IFNL2, IL6, IFNB1, BMP7, CD40, IL12A, PDGFA, PDGFC, CXCR1, IL9R, CTF1, CCR1, IL1R1, TGFBR2, TNFRSF25, IL12B, OSMR, IL18, PRLR, EGF, CXCL16, IL1RAP, EGFR, ACVR2A, TNFRSF12A, CCR5, TNFRSF18, CCL17",0.100179497572904,0.0061230850587888,FALSE
+"H1650","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.3743,1.09,0.316,3310,1,"CCL5, IFNA5, DDX58, IRF3, POLR3H, IL6, IFNB1, PYCARD, POLR3K, NFKBIB, IL18, ADAR",0.500312917381596,0,FALSE
+"H1650","Input","KEGG_DILATED_CARDIOMYOPATHY",0.38677,1.13,0.262,5099,1,"TNNC1, ITGA4, DAG1, GNAS, CACNA1D, CACNG4, ITGA1, SLC8A1, ITGA6, ACTB, TNNI3, ITGB8, TPM2, TPM1, PRKACG, ADCY1, ADCY7, ADRB1, PRKACA, CACNA2D2, ITGAV, LMNA, CACNB1, ITGA3, ITGB1, ITGB4, MYL3, ADCY6, TNNT2, CACNG1",0.581698708680255,0,FALSE
+"H1650","Input","KEGG_DNA_REPLICATION",0.35107,1.02,0.398,6811,1,"POLE4, POLD1, DNA2, LIG1, POLE, POLA2, RNASEH2A, POLD2, RPA3, RNASEH2C, RPA1, MCM5, RNASEH1, POLD3, RFC2, MCM6, RFC5",0.400116927926312,0,FALSE
+"H1650","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43449,1.27,0.13,5338,1,"ETV7, MAP2K1, NOTCH3, SPIRE1, EGFR, MAPK3, SOS1, ETS2, GRB2, SPIRE2",0.886056647693163,0,FALSE
+"H1650","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.23165,-0.869,0.687,16157,0.874,"GSTM3, GSTO1, ALDH3A1, CYP3A4, UGT2B7, MAOB, GSTT2, GSTM1, CYP3A5, MAOA, GSTM2, GSTZ1, GSTA4, GSTP1",0.16304326294045,0.058488567365597,FALSE
+"H1650","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.3639,1.07,0.347,3951,1,"UGT2B17, XDH, CDA, TYMP, TK1, UPP1, CES2, UPB1, UCKL1, NAT2, TK2",0.459670525209126,0,FALSE
+"H1650","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.31659,0.929,0.584,4794,0.967,"CHAD, ITGA4, DAG1, SDC4, ITGA1, LAMA5, SDC1, ITGA6, ITGB8, COL5A1, LAMA3, SDC2, HSPG2, LAMB2, LAMB1, LAMC2, LAMB3, ITGAV, TNC, ITGA3, ITGB1, COL11A2, ITGB4",0.233587152887601,0.0145735259169983,FALSE
+"H1650","Input","KEGG_ENDOCYTOSIS",0.45307,1.31,0.116,5492,1,"CSF1R, HSPA2, STAMBP, SH3GL2, CBLC, RAB22A, VPS28, VPS4A, EHD2, DNM3, EPN3, AGAP1, FGFR2, SH3GLB2, EHD1, EPN1, AP2S1, ITCH, NEDD4L, CHMP4B, CHMP2A, GRK3, AP2A1, CHMP5, DNAJC6, VPS37B, CXCR1, IQSEC2, CHMP3, RAB11FIP4, HSPA1A, ARAP2, PLD2, VPS4B, PARD3, HSPA1B, ASAP3, ACAP1, PARD6B, ASAP2, VTA1, ARFGAP1, PSD4, EGF, WWP1, CLTB, RAB11A, PIP5K1A, ADRB1, EGFR, CHMP6, RUFY1, TFRC, DAB2, EPN2, CCR5, PRKCI, RAB4A, PRKCZ, IQSEC1, SNF8, EPS15, SH3KBP1, NEDD4, CHMP2B, PLD1, PSD, ASAP1, RAB5C, DNM1, USP8, EHD3, LDLRAP1, CHMP4C, EHD4, SH3GLB1, ARFGAP3, GRK5, MET, RAB11FIP5, STAM2, SH3GL1, ARRB1, CDC42, DNM2, RAB5A",0.935542010773082,0,FALSE
+"H1650","Input","KEGG_ENDOMETRIAL_CANCER",0.34995,1.01,0.439,4157,0.999,"TCF7L1, CDH1, MAP2K1, AKT2, ERBB2, TCF7L2, EGF, PTEN, CTNNA1, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1",0.357535479757879,0.000434511774017692,FALSE
+"H1650","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37836,1.08,0.324,3705,1,"CCL5, ATP6V0D1, MAPK11, ATP6V1C1, PLCG2, NOD1, MAP3K14, TJP1, CXCR1, F11R, RAC1, MAPK13, ATP6V0A1, ADAM10, ATP6V0C, EGFR, ATP6AP1",0.489454989793388,0,FALSE
+"H1650","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.33392,0.973,0.535,4165,0.98,"CAMK2G, GAB1, PAK4, CBLC, MAP2K1, PLCG2, PTK2, TGFA, AKT2, MTOR, CAMK2D, ERBB2, EGF, EGFR, PAK6, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CDKN1A",0.271646217978772,0.00877392430750515,FALSE
+"H1650","Input","KEGG_ETHER_LIPID_METABOLISM",0.38083,1.11,0.302,6715,1,"PLA2G12A, PAFAH1B3, PLA2G4B, LPCAT2, PAFAH1B1, PLD2, LPCAT1, PLA2G7, PLD1, CHPT1, AGPS, PLA2G10, PLA2G4E, LPCAT4, PAFAH1B2, PLPP1",0.519993057042849,0,FALSE
+"H1650","Input","KEGG_FATTY_ACID_METABOLISM",0.23978,0.7,0.902,6379,0.99,"ACAA1, ACOX1, ACSL1, ECHS1, HADHA, ACSL3, CPT1A, ECI1, ALDH3A2, ACAT2, ACADVL, HADHB, CPT1B, ALDH9A1, ACAA2, ACOX3",0.0447934624580583,0.00436480540245009,FALSE
+"H1650","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.29266,0.859,0.681,4400,0.961,"MAPK11, MAP2K1, VAV3, PRKCD, PLCG2, PLA2G12A, AKT2, PLA2G4B, RAC1, VAV1, MAPK13, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1, PRKCE, MAP2K3",0.166852888087215,0.0172766123314547,FALSE
+"H1650","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.34365,1,0.443,5642,1,"VASP, DNM3, MAP2K1, VAV3, PRKCD, PLCG2, AKT2, PLA2G4B, SPHK2, LIMK2, RAC1, VAV1, PLD2, ASAP3, ASAP2, ARPC3, PIP5K1A, VAV2, MAPK3, PIK3R3, AKT3, ARPC5L, RAF1, PRKCE, PLD1, ASAP1, DNM1, SCIN, CFL2, CDC42, DNM2, PLCG1, CFL1, PLA2G4F, LIMK1",0.35359627377693,0,FALSE
+"H1650","Input","KEGG_FOCAL_ADHESION",0.3476,1.02,0.427,5345,1,"CHAD, ITGA4, PAK4, ARHGAP35, PDGFB, MYL9, VASP, BCAR1, MAP2K1, ITGA1, VAV3, LAMA5, PTK2, RAP1A, ITGA6, ACTB, PXN, AKT2, PDGFA, FLNB, PDGFC, ITGB8, RAPGEF1, PDGFD, COL5A1, ACTN4, RAC1, VAV1, LAMA3, MYLK2, ERBB2, CCND3, PPP1CB, EGF, PTEN, EGFR, LAMB2, PAK6, VAV2, MAPK3, PIK3R3, AKT3, ARHGAP5, LAMB1, CAV2, MYL5, LAMC2, BAD, RAF1, LAMB3, SOS1, ITGAV, MYL7, TNC, ITGA3, ITGB1, MYL12B, COL11A2, ITGB4, GRB2, RHOA, CAV1, LAMC1, MET, PAK2, ROCK1, CDC42",0.369572124974976,0,FALSE
+"H1650","Input","KEGG_FOLATE_BIOSYNTHESIS",0.59623,1.71,0.00758,771,0.58,"ALPP, SPR",2.12033079436795,0.236572006437063,FALSE
+"H1650","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.3083,-1.14,0.321,17725,0.707,"PFKFB1, PFKFB3, GMDS, PFKM, SORD, ALDOC, KHK, MTMR6",0.493494967595128,0.150580586203101,FALSE
+"H1650","Input","KEGG_GALACTOSE_METABOLISM",0.34964,1.01,0.445,7455,0.999,"B4GALT1, UGP2, PGM1, B4GALT2, GALT, HK2, HK1, AKR1B1, GLB1, PGM2, PFKP, PFKL, GALK1, MGAM",0.351639989019068,0.000434511774017692,FALSE
+"H1650","Input","KEGG_GAP_JUNCTION",0.31075,0.913,0.599,6281,0.943,"PDGFB, GNAS, MAP2K1, TJP1, PDGFA, PDGFC, PDGFD, GNAQ, TUBA4A, PRKACG, ADCY1, ADCY7, TUBB8, EGF, ADRB1, EGFR, MAPK3, PRKACA, ITPR2, RAF1, GUCY1B1, SOS1, GJD2, GNAI1, GUCY1A1, ADCY6, GRB2, TUBB6, GUCY1A2, MAPK7, HRAS, MAP3K2, TUBA8, PRKACB, SRC, TUBB4B",0.222573177610689,0.0254883072626717,FALSE
+"H1650","Input","KEGG_GLIOMA",0.37403,1.09,0.325,4849,1,"CAMK2G, E2F1, CALM3, PDGFB, MAP2K1, PLCG2, TGFA, AKT2, PDGFA, MTOR, CAMK2D, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, RAF1, SOS1, CDKN1A, CALML6, CALM1, GRB2",0.488116639021126,0,FALSE
+"H1650","Input","KEGG_GLUTATHIONE_METABOLISM",-0.23609,-0.857,0.595,16990,0.826,"PGD, GSTT2, GPX3, GSTM1, GPX2, ODC1, RRM1, GSTM2, GSTZ1, GSTA4, GSTP1",0.22548303427145,0.0830199526796178,FALSE
+"H1650","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.22898,-0.865,0.69,16976,0.844,"AGPAT1, DGKI, ALDH1B1, MBOAT1, ALDH2, DGAT2, GPAT4, DGKG, AGPAT3, AKR1A1",0.161150909262745,0.073657553374345,FALSE
+"H1650","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.25138,0.73,0.864,3291,0.993,"ACHE, CHKA, LCAT, CDS1, PLA2G12A, PLA2G4B, MBOAT7, LPCAT2, PLD2, DGKE, PLA2G15, DGKA, CHKB, ETNK2, LPCAT1",0.0634862575211067,0.00305075150461883,FALSE
+"H1650","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.25031,-0.946,0.5,17033,0.841,"MAOB, AMT, SARDH, CTH, MAOA, SHMT2",0.301029995663981,0.0752040042020878,FALSE
+"H1650","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.2593,0.753,0.857,6578,1,"ALDH3B2, PGAM1, PGM1, GAPDH, FBP2, GALM, PGAM4, LDHAL6B, ACSS2, GPI, ALDOA, ACSS1, HK2, HK1, ALDH1A3, ALDH3B1, ALDH3A2, PDHA1, ENO1, PGM2, ALDH9A1, PKM, PFKP, PDHB",0.0670191780768018,0,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.46894,1.36,0.087,4591,1,"CHST14, XYLT1, CHST7, CHST12, B4GALT7, CHPF, DSE, CHST11, CHST15, CSGALNACT1, CHST3",1.06048074738138,0,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.39462,1.16,0.22,3145,1,"XYLT1, NDST1, EXT2, HS2ST1, B4GALT7, EXT1",0.657577319177794,0,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.53584,1.55,0.0326,2510,0.775,"CHST6, B4GALT4, B4GALT1, ST3GAL1, B4GALT2, B3GNT2",1.48678239993206,0.11069829749369,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.35799,1.05,0.38,764,1,"HPSE, GALNS",0.42021640338319,0,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.34124,0.997,0.432,5398,1,"ST6GALNAC5, ST3GAL1, B4GALNT1, B3GALT4, HEXA, GLB1",0.364516253185088,0,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.46931,1.36,0.0786,1325,1,"FUT9, FUT1, ST3GAL1",1.10457745396059,0,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.62171,1.82,0.0043,2766,0.408,"B3GNT3, B4GALT4, B4GALT1, FUT9, FUT1, FUT3, ST3GAL4, B4GALT2, B3GNT2, ABO",2.36653154442041,0.38933983691012,FALSE
+"H1650","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.45711,1.32,0.099,4292,1,"GPAA1, PIGQ, PIGT, PIGO, PIGK, PIGG, PIGX, GPLD1, PIGU, PIGV, PIGN, PIGL",1.00436480540245,0,FALSE
+"H1650","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.57196,1.67,0.0131,4273,0.567,"MDH1, MTHFD2, ACO2, PGP, GRHPR, MTHFD1L, MDH2",1.88272870434424,0.246416941107093,FALSE
+"H1650","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.33254,0.966,0.517,6405,0.966,"CAMK2G, CALM3, GNAS, CACNA1D, MAPK11, MAP2K1, PRKCD, PLA2G12A, PLA2G4B, GNAQ, PLD2, CAMK2D, PRKACG, ADCY1, MAPK13, ADCY7, PTK2B, EGFR, MAPK3, PRKACA, ITPR2, RAF1, SOS1, CALML6, PLD1, MAP2K3, CALM1, ADCY6, GRB2, CDC42, MMP2, MAPK7, CGA, HRAS, PLA2G10, MAP3K2, PRKACB, SRC, PLA2G4E, HBEGF",0.286509456906058,0.0150228735845067,FALSE
+"H1650","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.24724,-0.913,0.524,11132,0.843,"IFNG, FASLG, KIR3DL2, IL2, FAS, CD28, KIR3DL1, KIR2DL3, PRF1, KLRD1, GZMB, CD86, TNF, IL1B, IL1A",0.280668713016273,0.0741724253752577,FALSE
+"H1650","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.2994,0.873,0.684,3717,0.972,"BMP5, WNT9A, BMP7, GLI3, WNT7B, WNT7A, WNT6, PRKACG, PRKACA, GAS1",0.164943898279884,0.0123337350737254,FALSE
+"H1650","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.27752,0.806,0.782,3762,0.978,"CSF1R, ITGA4, ITGA1, IL6, ANPEP, ITGA6, MME, IL9R, IL1R1, CD14, TFRC, CD59, CD9, CD55",0.106793246940152,0.00966114521239857,FALSE
+"H1650","Input","KEGG_HISTIDINE_METABOLISM",-0.35664,-1.32,0.129,15605,0.804,"DDC, HAL, AOC1, AMDHD1, ALDH3A1, MAOB, ACY3, ALDH1B1, ALDH2, HNMT, METTL2B, MAOA",0.889410289700751,0.0947439512515487,FALSE
+"H1650","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.49845,1.45,0.0595,6516,1,"POLD1, RAD51, XRCC3, POLD2, RPA3, NBN, RPA1, RAD52, EME1, XRCC2, RAD51C, RAD54B, POLD3, BLM",1.22548303427145,0,FALSE
+"H1650","Input","KEGG_HUNTINGTONS_DISEASE",0.21549,0.63,0.954,5129,0.998,"DNAI1, NDUFAB1, UQCRC2, POLR2K, CYCS, CYC1, POLR2I, POLR2C, AP2S1, UQCRFS1, DCTN1, DNAL1, AP2A1, DNAL4, GNAQ, NDUFS6, PPARG, NDUFB8, TAF4, TBPL2, TGM2, COX6B1, HAP1, CLTB, UQCR10, CASP8, NDUFA8, HTT, POLR2A, SDHA, NDUFB1, NDUFV2, COX6C, SDHB, EP300, NDUFB3, NDUFB9, SOD1, COX8A, NDUFB6, HDAC1, NDUFB7, TBP, CREB3, VDAC2",0.0204516252959049,0.000869458712628891,FALSE
+"H1650","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.37839,1.1,0.314,2500,1,"TNNC1, ITGA4, DAG1, CACNA1D, CACNG4, ITGA1, IL6, SLC8A1, PRKAA1, ITGA6, PRKAG2, ACTB, TNNI3, ITGB8, TPM2, TPM1",0.503070351926785,0,FALSE
+"H1650","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.34387,0.99,0.477,5527,0.974,"PLCD1, PLCE1, PLCG2, PIK3C2B, INPP4B, IMPA2, INPP5A, MINPP1, INPP1, ITPK1, PIP4K2C, INPP5E, PTEN, PIP5K1A, SYNJ1, INPP4A, INPPL1, PLCD3, IPPK, PIK3C2G, ISYNA1, CDIPT, PLCG1",0.321481620959886,0.0114410431213845,FALSE
+"H1650","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.28638,0.819,0.752,4861,0.986,"CBLC, CALM3, GYS1, MAP2K1, PRKAA1, PPP1R3C, PRKAG2, PHKB, PPP1R3D, AKT2, RAPGEF1, FBP2, SOCS1, MTOR, PHKG2, SH2B2, PRKACG, PTPN1, PPP1CB, PRKAR1B, MAPK3, FLOT2, PIK3R3, PRKACA, AKT3, PRKCI, PRKCZ, BAD, RAF1, SOS1, CALML6, PHKG1, TSC1, HK2, HK1, PTPRF, CALM1, RPTOR, GRB2, PRKAR2A",0.123782159408358,0.0061230850587888,FALSE
+"H1650","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.39617,1.15,0.223,1524,1,"ITGA4, CCL28, IL6, CD40, MAP3K14",0.651695136951839,0,FALSE
+"H1650","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30651,0.894,0.635,6363,0.956,"IFNL1, IFNL3, IL20RB, IFNA5, CBLC, STAT1, IFNL2, STAT4, STAT2, IL6, IFNB1, IL12A, AKT2, STAT3, IL9R, SOCS1, CTF1, IRF9, IL12B, CCND3, OSMR, SPRED2, PRLR, PIAS1, PIK3R3, AKT3, BCL2L1, TYK2, IFNLR1, SOS1, EP300, IL11RA, PTPN6, GRB2, JAK1, STAM2, SPRY3, IL3RA, JAK2, PIM1, IFNE, CLCF1, IL22, CSF3R, PIK3CB, IL4R, STAM, IL15",0.197226274708024,0.0195421077238999,FALSE
+"H1650","Input","KEGG_LEISHMANIA_INFECTION",0.36569,1.06,0.351,2960,1,"ITGA4, ITGB2, STAT1, FCGR3B, MAPK11, IL12A, NCF4, MYD88, TAB2, IL12B, NFKBIB, MAPK13",0.454692883534176,0,FALSE
+"H1650","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.4217,1.24,0.16,5643,0.99,"ITGA4, ARHGAP35, ITGB2, MYL9, CTNND1, VASP, MAPK11, BCAR1, VAV3, RASSF5, PLCG2, PTK2, RAP1A, ACTB, PXN, F11R, OCLN, ACTN4, RAC1, CLDN7, VAV1, NCF4, CLDN23, CLDN4, MAPK13, AFDN, PTK2B, CTNNA1, VAV2, PIK3R3, ARHGAP5, MYL5, MYL7, GNAI1, CLDN9, ITGB1, MYL12B, RHOA, EZR, CLDN8, ESAM, ROCK1, CDC42, MMP2, PLCG1, CLDN1, ACTN1",0.795880017344075,0.00436480540245009,FALSE
+"H1650","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.27111,0.78,0.803,6187,0.991,"ECHS1, HADHA, YOD1, ALDH3A2, ALDH9A1",0.095284454721319,0.00392634551472468,FALSE
+"H1650","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.2528,0.726,0.869,1909,0.984,"CYP2E1, PLA2G12A, PLA2G4B",0.0609802235513335,0.00700490156865849,FALSE
+"H1650","Input","KEGG_LONG_TERM_DEPRESSION",0.23816,0.699,0.904,4678,0.984,"GNAO1, GNAS, PPP2R1A, MAP2K1, PLA2G12A, RYR1, PLA2G4B, GNAQ, MAPK3, ITPR2, RAF1, GUCY1B1, GNAI1, GUCY1A1, GNA12",0.0438315695246367,0.00700490156865849,FALSE
+"H1650","Input","KEGG_LONG_TERM_POTENTIATION",0.38026,1.12,0.286,4692,1,"CHP1, CAMK2G, CALM3, PPP3R1, MAP2K1, PPP3CA, RAP1A, RPS6KA1, GNAQ, CAMK2D, PRKACG, ADCY1, PPP1CB, MAPK3, PRKACA, GRIN2A, ITPR2, RAF1, CALML6, EP300, CALM1",0.543633966870957,0,FALSE
+"H1650","Input","KEGG_LYSINE_DEGRADATION",0.33936,0.977,0.496,6687,0.992,"BBOX1, OGDH, PLOD2, KMT5A, KMT5C, SETD2, ECHS1, HADHA, PLOD1, AASDHPPT, AADAT, NSD2, KMT5B, ALDH3A2, SETD1A, ACAT2, ALDH9A1, SETD1B, NSD1, PLOD3, TMLHE, EHMT1",0.304518323509803,0.00348832784582135,FALSE
+"H1650","Input","KEGG_LYSOSOME",0.32758,0.951,0.537,5502,0.967,"AP1G1, AP3S1, GGA2, CTSV, ATP6V0D1, GALNS, MFSD8, GM2A, AP4E1, MANBA, LAPTM4A, CTSA, ARSA, AP1M2, GNPTAB, DNASE2, ACP2, CTSH, PPT1, ABCB9, PLA2G15, AP1S1, ATP6V0A1, LAMP3, ATP6V0C, CLTB, CTSZ, GALC, ATP6AP1, AP4M1, PPT2, AP1B1, NAGPA, CTSL, CD68, ATP6V0A4, HEXA, GLB1, PSAP, NAGLU, SLC11A1",0.270025714300444,0.0145735259169983,FALSE
+"H1650","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.30049,0.868,0.661,4157,0.975,"CHP1, DUSP14, NTF4, HSPA2, STK3, MAP3K5, HSPB1, PDGFB, PPP3R1, CACNA1D, CACNG4, MAPK11, MAP2K1, PPP3CA, FGFR2, TAOK3, RAP1A, PLA2G12A, NGF, MAP3K14, FGF11, FGF2, MAPK8IP2, JUND, AKT2, PDGFA, FLNB, PLA2G4B, MAPKAPK3, RPS6KA1, RAC1, MAP3K6, MAP3K8, ECSIT, HSPA1A, PPP5C, MAP4K2, IL1R1, TGFBR2, TAB2, PRKACG, RPS6KA4, RASGRP4, HSPA1B, RRAS, CD14, MAPK13, NF1, MAP3K20, TAOK2, EGF, NFKB2, MAPK8IP3, EGFR, STK4, RASA1, MAPK3, DUSP9, PRKACA, AKT3, RAF1, CACNA2D2, MAP4K3, RAPGEF2, SOS1",0.17979854051436,0.0109953843014632,FALSE
+"H1650","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.50536,-1.93,0,15732,0.188,"HNF4A, BHLHA15, HNF1A, HHEX, ONECUT1, FOXA3, HNF1B, FOXA2, GCK, HNF4G",Inf,0.72584215073632,TRUE
+"H1650","Input","KEGG_MELANOGENESIS",0.35633,1.03,0.402,5327,1,"TCF7L1, CAMK2G, GNAO1, CALM3, GNAS, WNT9A, MAP2K1, WNT7B, GNAQ, WNT7A, MITF, WNT6, CAMK2D, PRKACG, ADCY1, FZD6, TCF7L2, ADCY7, FZD9, MAPK3, PRKACA, FZD2, RAF1, CALML6, EP300, GNAI1, CALM1, FZD1, ADCY6, CREB3, KITLG, WNT9B",0.39577394691553,0,FALSE
+"H1650","Input","KEGG_MELANOMA",0.33754,0.968,0.5,4165,0.971,"E2F1, CDH1, PDGFB, MAP2K1, FGF11, FGF2, AKT2, PDGFA, PDGFC, PDGFD, MITF, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, CDKN1A",0.301029995663981,0.0127807700919951,FALSE
+"H1650","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.25715,-0.946,0.488,16157,0.841,"GSTM3, GSTO1, ALDH3A1, CYP3A4, UGT2B7, GSTT2, GSTM1, CYP3A5, AKR1C2, AKR1C1, AKR1C3, GSTM2, GSTZ1, GSTA4, GSTP1",0.311580177997289,0.0752040042020878,FALSE
+"H1650","Input","KEGG_MISMATCH_REPAIR",0.43736,1.28,0.14,6811,1,"POLD1, EXO1, LIG1, PMS2, POLD2, RPA3, RPA1, POLD3, RFC2, RFC5",0.853871964321762,0,FALSE
+"H1650","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.27644,0.809,0.779,7014,0.981,"PRKAA1, AKT2, RPS6KA1, MTOR, ULK2, DDIT4, MAPK3, PIK3R3, RICTOR, AKT3, CAB39, ULK1, TSC1, RPTOR, MLST8, RHEB, TSC2, PIK3CB, EIF4E, VEGFB, BRAF, VEGFC",0.108462542327436,0.0083309926200515,FALSE
+"H1650","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.34616,1.01,0.45,3669,0.999,"CHP1, IFNA5, RAET1E, HCST, ITGB2, RAET1G, RAET1L, FCGR3B, PPP3R1, MAP2K1, PPP3CA, VAV3, PLCG2, IFNB1, NFAT5, BID, RAC1, VAV1, NFATC1, PTK2B, ULBP2, NFATC3, VAV2, MAPK3, PIK3R3",0.346787486224656,0.000434511774017692,FALSE
+"H1650","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.18027,0.523,0.994,5211,0.997,"GRIN3B, ADORA2A, ADRA2A, OPRK1, MLNR, THRB, CHRM4, P2RY2, P2RX2, S1PR5, TRPV1, LPAR2, ADRA1B, HTR1D, ADRA2B, S1PR1, P2RX5, OXTR, HTR6, PARD3, P2RX4, GABRE, PRLR, S1PR2, ADRB1, P2RY13, F2RL1, ADORA2B, GRIN2A, GALR2, VIPR1, GRM4, S1PR3, GABBR2, TBXA2R, GABRB3, PTAFR, GALR3, CHRNA4, P2RY6, NR3C1, GPR156, GLRB, C5AR1",0.00261361560268669,0.00130484168834428,FALSE
+"H1650","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.31006,0.9,0.622,4851,0.958,"NTF4, CAMK2G, GAB1, MAP3K5, CALM3, YWHAZ, MAPK11, MAP2K1, PRKCD, PLCG2, RAP1A, YWHAB, NGF, ZNF274, AKT2, RAPGEF1, RPS6KA1, RAC1, TP73, CAMK2D, SH2B2, RPS6KA4, NFKBIB, ARHGDIB, MAPK13, RIPK2, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CALML6, CALM1, SH2B1, GRB2, RHOA",0.206209615309181,0.0186344909214556,FALSE
+"H1650","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.31926,-1.17,0.198,18057,0.772,"PNP, NAMPT, NMNAT3, NNT, NADSYN1",0.703334809738469,0.112382699664264,FALSE
+"H1650","Input","KEGG_NITROGEN_METABOLISM",-0.42922,-1.65,0.0361,15897,0.276,"CA7, HAL, CA3, CA14, AMT, CA8, GLUD2, CTH, CPS1, CA12, GLS2, CA13",1.44249279809434,0.559090917934782,FALSE
+"H1650","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.34318,0.993,0.465,4230,1,"CCL5, MAPK11, IL6, NOD1, TAB3, PYCARD, TAB2, NFKBIB, IL18, MAPK13, RIPK2, MAPK3, CASP8, NLRC4, ERBIN, CARD8, CASP1",0.332547047110046,0,FALSE
+"H1650","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.23973,0.692,0.915,5915,0.977,"XRCC4, XRCC6, NHEJ1, PRKDC",0.0385789059335517,0.0101054362812269,FALSE
+"H1650","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.33667,0.983,0.49,4157,0.985,"E2F1, MAP2K1, RASSF5, PLCG2, TGFA, AKT2, ERBB2, EGF, RXRA, EGFR, STK4, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1",0.309803919971486,0.00656376950238827,FALSE
+"H1650","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.36217,1.05,0.36,5177,1,"DTX4, PSENEN, KAT2B, DTX3L, NOTCH3, JAG2, DTX2, NUMBL, KAT2A, CTBP2, LFNG, EP300, HDAC1, DLL3, MAML2, HES5",0.443697499232713,0,FALSE
+"H1650","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.33265,0.968,0.51,4716,0.971,"ERCC4, POLE4, POLD1, RAD23A, GTF2H5, LIG1, POLE, ERCC2, ERCC1, RBX1, POLD2, RPA3, ERCC6, CETN2, RAD23B, RPA1",0.292429823902064,0.0127807700919951,FALSE
+"H1650","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.30488,0.894,0.64,5036,0.956,"MGAT5B, MAN1B1, B4GALT1, RPN2, MGAT3, DPM1, STT3A, B4GALT2, STT3B, ALG12, MAN2A1, RFT1, MGAT4A, MOGS, DOLPP1, MGAT1, MGAT2, DDOST",0.193820026016113,0.0195421077238999,FALSE
+"H1650","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.17232,-0.643,0.953,10204,1,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR6A2, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, ADCY3, OR5B3, OR10G3, OR10H1, OR1D2, OR52M1, OR2A7, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51E1, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR1N1, OR2C1, OR10G4, PDC, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR4D5, OR5K2, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, CAMK2B, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR51E2, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR11H6, OR52N4, OR10V1, CLCA4, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR51I1, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, ARRB2, OR8D2, OR2T33, OR1J2, OR2A5, OR52H1, CALM2, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, CALML3, OR4D1, OR8G1, OR4F15, OR52B6, OR2A25, GUCY2D, OR1Q1, OR8A1, CALML5, OR2B2, OR1K1, OR4F3, OR11H4, OR51B4, OR13A1, OR10AD1, OR6B2, OR2K2, OR13H1, OR7D2, OR2A14, OR13J1, OR4F16, OR4F17, OR2W3, PDE1C, OR56B4, OR1L8, OR2AE1, OR2H2, PRKX, OR52W1, GUCA1B, PRKG1, PRKG2",0.0209070993616736,0,FALSE
+"H1650","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.29854,0.883,0.645,6661,0.956,"MTHFD2, MTHFS, MTHFR, MTHFD1L, SHMT1, DHFR, ATIC, MTHFD2L",0.190440285364732,0.0195421077238999,FALSE
+"H1650","Input","KEGG_OOCYTE_MEIOSIS",0.39828,1.14,0.264,5310,1,"CHP1, CAMK2G, CALM3, YWHAZ, PLK1, PPP2R1A, PPP3R1, MAP2K1, PPP3CA, AURKA, YWHAB, PPP2R5E, CCNE1, PKMYT1, RPS6KA1, ANAPC2, SPDYA, CAMK2D, PRKACG, ADCY1, PPP1CB, ANAPC10, ADCY7, CDC23, SMC1B, SGO1, FBXO5, REC8, MAPK3, PRKACA, ITPR2, RBX1, ANAPC7, CCNB1, CALML6, CCNE2, CALM1, CDC20, ADCY6, YWHAE, BUB1, MAD2L2, PPP2CA",0.578396073130169,0,FALSE
+"H1650","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.23116,0.676,0.916,5738,0.985,"MANBA, NEU2, MAN2C1, HEXA, GLB1, FUCA2",0.0381045263321496,0.00656376950238827,FALSE
+"H1650","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.25352,0.735,0.88,5038,1,"NDUFAB1, UQCRC2, ATP6V0D1, ATP6V1C1, CYC1, UQCRFS1, LHPP, NDUFS6, NDUFB8, COX17, ATP6V0A1, COX6B1, ATP6V0C, COX15, UQCR10, NDUFA8, ATP6AP1, SDHA, NDUFB1, NDUFV2, ATP5MG, COX6C, SDHB, NDUFB3, NDUFB9, COX8A, NDUFB6, ATP6V1B1, NDUFB7, ATP6V0A4",0.0555173278498314,0,FALSE
+"H1650","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.46457,1.35,0.0963,5221,1,"C1GALT1, GALNT7, GALNT3, B4GALT5, ST3GAL1, GALNT6, GALNT2, GALNT14, GALNT12, GALNT10, GCNT4, C1GALT1C1, GALNT9, GALNT13, GCNT1",1.01637371287547,0,FALSE
+"H1650","Input","KEGG_P53_SIGNALING_PATHWAY",0.36095,1.04,0.393,4216,1,"TP53AIP1, SIAH1, TP53I3, CYCS, EI24, CHEK2, BID, CCNE1, SFN, PERP, IGFBP3, GTSE1, SERPINB5, TP73, CCND3, CHEK1, SHISA5, PTEN, CASP8, RRM2, CDKN1A, CCNB1",0.405607449624573,0,FALSE
+"H1650","Input","KEGG_PANCREATIC_CANCER",0.35285,1.03,0.413,4020,1,"E2F1, STAT1, MAP2K1, TGFA, AKT2, STAT3, RAC1, SMAD2, TGFBR2, ERBB2, EGF, RAD51, RALA, EGFR, MAPK3, RALBP1, PIK3R3, AKT3, BCL2L1, BAD, RAF1, RALB",0.384049948343599,0,FALSE
+"H1650","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.19433,0.564,0.972,5637,1,"PPCS, UPB1, PANK4, DPYD, PPCDC",0.0123337350737254,0,FALSE
+"H1650","Input","KEGG_PARKINSONS_DISEASE",0.20965,0.61,0.952,4938,1,"NDUFAB1, UQCRC2, PINK1, UBE2G1, CYCS, CYC1, UQCRFS1, UBE2L6, TH, UBA7, NDUFS6, NDUFB8, COX6B1, UQCR10, NDUFA8, UBE2G2, SDHA, NDUFB1, NDUFV2, COX6C, SDHB, NDUFB3, NDUFB9, COX8A, NDUFB6, PARK7, NDUFB7",0.0213630516155257,0,FALSE
+"H1650","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.32728,0.951,0.531,6605,0.967,"CDH1, YWHAZ, ACTB, OCLN, TUBA4A, KRT18, CD14, ARPC3, TUBB8, ARPC5L, ITGB1, RHOA, TUBB6, EZR, ROCK1, CDC42, CLDN1, NCK2, YWHAQ, TUBA8, TUBB4B, TUBB3, TUBA1B",0.274905478918531,0.0145735259169983,FALSE
+"H1650","Input","KEGG_PATHWAYS_IN_CANCER",0.28172,0.815,0.747,5527,0.986,"CSF1R, TCF7L1, E2F1, CBLC, STAT1, CDH1, PDGFB, WNT9A, MAP2K1, CYCS, TFG, IL6, RASSF5, LAMA5, PLCG2, PTK2, FGFR2, EGLN3, ITGA6, EPAS1, GLI3, TGFA, BID, CCNE1, FGF11, FGF2, TRAF4, WNT7B, AKT2, PDGFA, STAT3, JUP, MTOR, RAC1, DAPK2, SMAD2, WNT7A, EGLN2, LAMA3, MITF, PPARG, TGFBR2, WNT6, ERBB2, CUL2, FZD6, TCF7L2, EGF, PTEN, RAD51, NFKB2, DAPK1, FZD9, CTNNA1, RALA, RXRA, EGFR, STK4, CTBP2, LAMB2, PIAS1, MAPK3, RALBP1, CASP8, PIK3R3, RUNX1, AKT3, LAMB1, BCL2L1, FZD2, LAMC2, BAD, RAF1, SKP2, RBX1, RALB, LAMB3, SOS1, CDKN1A, ITGAV, PLD1, EP300, BMP2, CCNE2, CCNA1, ITGA3, ITGB1, FZD1, GRB2, RHOA, HDAC1, LAMC1, MET, FOS, ELOC, PML, JAK1, KITLG, WNT9B, RALGDS, CDC42, FGF1, APPL1, MMP2, PLCG1",0.126679398184601,0.0061230850587888,FALSE
+"H1650","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.31844,0.917,0.603,4890,0.961,"UGT2B17, UGP2, RPEL1, RPE, DHDH, AKR1B1",0.219682687859849,0.0172766123314547,FALSE
+"H1650","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.36285,1.06,0.366,3657,1,"PGM1, PGLS, RPEL1, FBP2, GPI, RBKS, RPE, ALDOA, DERA",0.436518914605589,0,FALSE
+"H1650","Input","KEGG_PEROXISOME",0.31307,0.911,0.593,5734,0.938,"PXMP4, XDH, ACAA1, ECH1, SLC25A17, NUDT19, ACOX1, PEX10, PEX13, PRDX5, ACOT8, ACSL1, MPV17L, PEX3, MVK, DECR2, ACSL3, PEX14, SOD1, PRDX1, GSTK1, IDH2, ABCD1, IDH1, AGPS",0.226945306635737,0.0277971616209356,FALSE
+"H1650","Input","KEGG_PHENYLALANINE_METABOLISM",0.32357,0.931,0.575,5986,0.972,"ALDH3B2, GOT2, TAT, PRDX6, ALDH1A3, ALDH3B1, MIF, GOT1",0.24033215531037,0.0123337350737254,FALSE
+"H1650","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.34337,1,0.44,4869,1,"PLCD1, PLCE1, CALM3, CDS1, PLCG2, PIK3C2B, INPP4B, IMPA2, INPP5A, INPP1, ITPK1, DGKE, PIP4K2C, DGKA, INPP5E, PTEN, PIP5K1A, PIK3R3, SYNJ1, ITPR2, INPP4A, CALML6, INPPL1, PLCD3, IPPK, CALM1, PIK3C2G",0.356547323513813,0,FALSE
+"H1650","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.45732,1.34,0.0923,3279,1,"EARS2, UGT2B17, BLVRB, HMOX2, FTH1, ALAS1, UROS, HMOX1, ALAS2, COX15",1.03479829897409,0,FALSE
+"H1650","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.2677,0.774,0.827,3351,0.993,"SLC27A6, SCD5, ANGPTL4, SLC27A4, ACAA1, ACOX1, PPARG, ACSL1, FABP5, RXRA",0.0824944904474534,0.00305075150461883,FALSE
+"H1650","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.37845,1.09,0.323,245,1,"CYP7B1",0.490797477668897,0,FALSE
+"H1650","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.24562,-0.945,0.479,15016,0.8,"ZAP70, LCK, CD3D, IL2RG, CD19, RAG1, BTK, TNFRSF13C, IGLL1, CD4, DCLRE1C, JAK3, RFXAP",0.319664486585437,0.0969100130080564,FALSE
+"H1650","Input","KEGG_PRION_DISEASES",0.36312,1.07,0.356,3687,1,"CCL5, MAP2K1, IL6, HSPA1A, PRKACG, STIP1, MAPK3, PRKACA",0.448550002027125,0,FALSE
+"H1650","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.32122,0.935,0.567,5242,0.971,"PLK1, MAPK11, MAP2K1, AKT2, PKMYT1, RPS6KA1, ANAPC2, SPDYA, PRKACG, ADCY1, ANAPC10, MAPK13, ADCY7, CDC23, MAPK3, PIK3R3, PRKACA, AKT3, RAF1, ANAPC7, CCNB1, CDC25A, CDC25B, GNAI1, CCNA1, ADCY6, CCNA2, BUB1, MAD2L2",0.246416941107093,0.0127807700919951,FALSE
+"H1650","Input","KEGG_PROPANOATE_METABOLISM",-0.26429,-1.01,0.352,16336,0.817,"SUCLA2, LDHC, EHHADH, PCCB, ACADM, ALDH1B1, ALDH2, ACSS3, ALDH6A1, PCCA",0.453457336521869,0.0877779434675845,FALSE
+"H1650","Input","KEGG_PROSTATE_CANCER",0.289,0.843,0.751,4535,0.971,"TCF7L1, E2F1, PDGFB, MAP2K1, FGFR2, TGFA, CCNE1, AKT2, PDGFA, PDGFC, PDGFD, MTOR, ERBB2, TCF7L2, EGF, PTEN, EGFR, MAPK3, PIK3R3, AKT3, BAD, RAF1, SOS1, CDKN1A, EP300, CCNE2",0.124360062995832,0.0127807700919951,FALSE
+"H1650","Input","KEGG_PROTEASOME",0.29886,0.866,0.695,6227,0.971,"PSMA2, PSMB10, PSMC4, PSMA7, PSMB6, PSMD11, PSMB3, PSMD8, PSMD12, PSMF1, PSMD7, PSMB1, PSMB11, PSMB2, PSMC3, PSMA6, PSMA4, PSMB9, PSMB7",0.158015195409886,0.0127807700919951,FALSE
+"H1650","Input","KEGG_PROTEIN_EXPORT",-0.33128,-1.18,0.2,17269,0.839,"SPCS2, SEC62, IMMP2L, OXA1L, SEC63",0.698970004336019,0.0762380391712997,FALSE
+"H1650","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.24015,0.702,0.899,2164,0.995,"GLS, MDH1, SLC25A10",0.0462403082667712,0.00217691925427455,FALSE
+"H1650","Input","KEGG_PURINE_METABOLISM",0.20608,0.602,0.965,6278,0.993,"POLR2K, XDH, GDA, POLR3H, PAPSS2, POLR2I, POLE4, POLR2C, POLD1, DGUOK, ADK, NME4, NUDT9, ENTPD6, POLR3K, ADCY1, PAPSS1, NPR1, NME3, POLE, ADCY7, ADA, AK2, PDE8A, PDE5A, POLA2, RRM2, POLR2A, POLD2, NME6, GUCY1B1, PDE6G, GUCY1A1, ADCY6, ENTPD2, POLR1A, GUCY1A2, AK4, AK1, POLR2F, NT5C3A, PDE9A, DCK, NT5C2, ENTPD5, ATIC, PNPT1, POLD3, PKM, PAICS",0.0154726866562074,0.00305075150461883,FALSE
+"H1650","Input","KEGG_PYRIMIDINE_METABOLISM",0.35272,1.02,0.425,4082,1,"DHODH, POLR2K, CDA, POLR3H, POLR2I, POLE4, POLR2C, POLD1, DTYMK, CMPK2, TYMP, NME4, TK1, ENTPD6, POLR3K, UPP1, CTPS1, NME3, POLE, UPB1, UCKL1, DUT, POLA2, RRM2, POLR2A, TK2, POLD2, NME6",0.371611069949688,0,FALSE
+"H1650","Input","KEGG_PYRUVATE_METABOLISM",0.32653,0.947,0.544,6578,0.968,"PC, MDH1, LDHAL6B, ACSS2, GRHPR, ACSS1, MDH2, AKR1B1, ALDH3A2, PDHA1, ACAT2, ALDH9A1, PKM, ME3, PDHB",0.26440110030182,0.0141246426916063,FALSE
+"H1650","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.3528,1.03,0.434,5643,1,"PFN4, SSH2, ITGA4, PAK4, ARHGAP35, ITGB2, PDGFB, MYL9, CHRM4, MYH14, BCAR1, MAP2K1, ITGA1, VAV3, PTK2, FGFR2, ITGA6, ACTB, ARHGEF1, FGD3, PXN, FGF11, FGF2, PDGFA, PDGFC, ITGB8, PDGFD, TIAM1, SLC9A1, LIMK2, ACTN4, RAC1, BAIAP2, VAV1, RDX, PFN1, MYLK2, PIP4K2C, RRAS, PPP1CB, CD14, ARPC3, EGF, PIP5K1A, EGFR, CYFIP1, PAK6, VAV2, MAPK3, SSH3, PIK3R3, MYL5, ARPC5L, RAF1, BRK1, SOS1, TIAM2, ITGAV, MYL7, MRAS, GNA12, ITGA3, ITGB1, MYH9, MYL12B, ITGB4, SCIN, NCKAP1, RHOA, CFL2, EZR, PAK2, ROCK1, CDC42, ITGAE, FGF1, IQGAP1, CFL1, LIMK1, ACTN1",0.362510270487489,0,FALSE
+"H1650","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.45218,1.3,0.101,3126,1,"IFNA5, GABARAPL2, ATG12, PRKAA1, ATG4B, ULK2, ATG7, ATG4D",0.995678626217357,0,FALSE
+"H1650","Input","KEGG_RENAL_CELL_CARCINOMA",0.40227,1.17,0.221,7564,1,"GAB1, PAK4, PDGFB, MAP2K1, EGLN3, RAP1A, EPAS1, TGFA, AKT2, RAPGEF1, RAC1, EGLN2, CUL2, PAK6, MAPK3, PIK3R3, AKT3, RAF1, RBX1, SOS1, EP300, GRB2, MET, PAK2, ELOC, CDC42, SLC2A1, HRAS, PIK3CB, TGFB3, VEGFB, BRAF, CRKL, VEGFC, SOS2, CRK, TGFB2, FLCN, CREBBP, ETS1, TGFB1",0.655607726314889,0,FALSE
+"H1650","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.4735,1.38,0.0652,1966,1,"ACE2, ANPEP, MME, CTSA",1.18575240426808,0,FALSE
+"H1650","Input","KEGG_RETINOL_METABOLISM",0.17876,0.519,0.989,1040,0.992,"DHRS9, UGT2B17, CYP26B1",0.0048037084028206,0.00348832784582135,FALSE
+"H1650","Input","KEGG_RIBOFLAVIN_METABOLISM",0.23988,0.694,0.894,4592,0.982,"MTMR2, ACP2, MTMR1, ACP1, PHPT1",0.0486624812040823,0.00788851221305034,FALSE
+"H1650","Input","KEGG_RIBOSOME",-0.68738,-2.62,0,16978,0.00834,"RPL34, RPL4, RPL35A, RPL19, RPL26, RPL39, RPS17, RPL17, RPL37A, RPS7, RPL18A, RPS4Y1, RPS3, RPS29, RPL9, RPL38, RPL7, RPL5, RPS3A, RPLP0, RPL22L1, RPL31, RPL23A, RPS27A, RPS23, RPL27, RPS8, RPS25, RPS4X, RPS27, RPL36A, RPS15, RPS18, RPL3, RPS28, RPS10, RPL10A, RPL21, RPL10, RPL36, RPLP2, RPS12, RPL27A, RPS13, RPL30",Inf,2.07883394936226,TRUE
+"H1650","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38733,1.12,0.272,4825,1,"IFNA5, DDX58, IRF3, IFIH1, TRADD, ISG15, MAPK11, ATG12, IFNB1, IL12A, CYLD, TANK, IL12B, NFKBIB, MAPK13, CASP8, AZI2, DHX58, TKFC, TRIM25, TBK1, TBKBP1",0.565431095965801,0,FALSE
+"H1650","Input","KEGG_RNA_DEGRADATION",0.37899,1.09,0.317,4271,1,"PARN, EXOSC6, LSM4, EDC4, DCPS, TENT4A, CNOT3, PATL1, CNOT1, EXOSC1, C1D, SKIV2L, EXOSC4, CNOT8, CNOT4, LSM5, LSM3, PAPOLB, EXOSC3, EXOSC5, EXOSC10",0.498940737782249,0,FALSE
+"H1650","Input","KEGG_RNA_POLYMERASE",0.30447,0.886,0.636,1179,0.958,"POLR2K, POLR3H, POLR2I, POLR2C",0.196542884351586,0.0186344909214556,FALSE
+"H1650","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.32823,0.954,0.526,5641,0.981,"PAPSS2, PAPSS1, AHCYL2, AHCY, CBS, LCMT1, GGT1, GGT7, MAT2B, MAT2A",0.279014255846261,0.0083309926200515,FALSE
+"H1650","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.24963,0.727,0.871,4699,0.99,"E2F1, CYCS, LAMA5, PTK2, ITGA6, CCNE1, TRAF4, AKT2, LAMA3, PTEN, RXRA, LAMB2, PIAS1, PIK3R3, AKT3, LAMB1, BCL2L1, LAMC2, SKP2, LAMB3, ITGAV, CCNE2, ITGA3, ITGB1",0.0599818449923368,0.00436480540245009,FALSE
+"H1650","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.18256,0.526,0.991,3492,1,"STX11, YKT6, STX16, VAMP8, VTI1A",0.00392634551472468,0,FALSE
+"H1650","Input","KEGG_SPHINGOLIPID_METABOLISM",0.28335,0.814,0.782,4756,0.98,"SPTLC1, SMPD4, SPHK2, ARSA, DEGS1, GALC, NEU2, SMPD3, B4GALT6, SGMS2",0.106793246940152,0.00877392430750515,FALSE
+"H1650","Input","KEGG_SPLICEOSOME",0.29423,0.855,0.706,6805,0.962,"SF3B3, DHX38, HSPA2, CTNNBL1, PCBP1, LSM4, PRPF31, AQR, SRSF6, PUF60, TRA2A, SNRNP70, USP39, PHF5A, HSPA1A, U2AF2, SRSF9, SNRPA, HSPA1B, SNRPD3, PRPF40B, PRPF38A, SNRNP27, CHERP, U2SURP, LSM5, LSM3, SMNDC1, SNRPD2, TXNL4A, PPIE, BCAS2, SNRPG, PRPF4, ALYREF, SF3B4, BUD31, PRPF6, ZMAT2, DHX15, LSM6, SRSF4, PRPF38B, PLRG1, SNRPA1, RBM22, DDX46, DDX42, RBM25, HSPA6, HNRNPK, CWC15, PRPF8, SRSF8, SF3B5, PQBP1, WBP11",0.151195298948196,0.0168249279621871,FALSE
+"H1650","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.27188,0.798,0.796,6169,0.985,"UGT2B17, GYS1, UGP2, PGM1, AMY1A, GPI, HK2, HK1, AMY1B, UXS1, PYGL, PGM2, AGL",0.0990869322623309,0.00656376950238827,FALSE
+"H1650","Input","KEGG_STEROID_BIOSYNTHESIS",0.24322,0.711,0.897,7038,0.993,"DHCR24, SQLE, MSMO1, SOAT1, SC5D, EBP, LIPA",0.0472075569559079,0.00305075150461883,FALSE
+"H1650","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.39955,1.16,0.246,1208,1,"SULT2B1, SULT1E1, CYP7B1, SRD5A1, UGT2B17, CYP1B1",0.609064892896621,0,FALSE
+"H1650","Input","KEGG_SULFUR_METABOLISM",0.72982,2.13,0,4125,0.058,"SULT2B1, SULT1E1, PAPSS2, SULT1A4, CHST12, PAPSS1, SULT1A3, CHST11, SULT1A2, SUOX",Inf,1.23657200643706,TRUE
+"H1650","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.16749,-0.559,1,14929,0.989,"FCGR2C, C7, GRIN2B, CD86, CTSG, C1S, C4B, ACTN2, C4A, FCGR2A, TNF, SNRPD1, C1R, C2",0,0.0048037084028206,FALSE
+"H1650","Input","KEGG_TASTE_TRANSDUCTION",0.44181,1.28,0.127,4814,1,"KCNB1, TAS2R1, GNAS, GNG13, TAS2R43, TAS2R20, PRKACG, SCNN1G, TAS2R46, PRKACA, GRM4, TAS2R5, ASIC2, ADCY6",0.896196279044043,0,FALSE
+"H1650","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.42673,1.25,0.158,4965,1,"CSAD, GAD1, GGT1, GGT7",0.801342913045577,0,FALSE
+"H1650","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.29894,-1.12,0.239,17791,0.698,"IDI1, FDPS, PDSS2",0.621602099051862,0.156144577376839,FALSE
+"H1650","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.25714,0.742,0.865,5940,1,"BMP5, PPP2R1A, RBL2, E2F4, BMP7, SMAD2, NOG, ZFYVE16, TGFBR2, SMAD6, GDF6, ACVR2A, MAPK3, RBL1, ID1, RBX1, EP300, BMP2, AMH, SMAD1, RHOA, ID4, BMPR1A, ROCK1, PPP2CA, CUL1, ID3, THBS1, SMURF1",0.0629838925351858,0,FALSE
+"H1650","Input","KEGG_THYROID_CANCER",0.38796,1.13,0.27,3590,1,"TCF7L1, CDH1, MAP2K1, TFG, PPARG, TCF7L2, RXRA, MAPK3",0.568636235841013,0,FALSE
+"H1650","Input","KEGG_TIGHT_JUNCTION",0.43013,1.24,0.166,6038,0.99,"MYH15, SPTAN1, EPB41L1, MYL9, MYH14, PPP2R1A, SYMPK, CGN, PRKCD, ACTB, CSNK2A2, MYH3, TJP3, TJP1, AKT2, F11R, OCLN, ACTN4, AMOTL1, CLDN7, CLDN23, LLGL2, CLDN4, EXOC3, PARD3, RRAS, PARD6B, MAP3K20, AFDN, PTEN, CTNNA1, YBX3, TJP2, AKT3, PRKCI, CASK, MYL5, PRKCZ, PRKCE, PPP2R2D, MYL7, GNAI1, MRAS, CLDN9, MYH9, MYL12B, RHOA, VAPA, PATJ, PPP2R2C, MPDZ, CLDN8, PPP2CA, CDC42, CLDN1, ACTN1, PRKCH, MYH7B, MAGI1, HRAS",0.779891911959945,0.00436480540245009,FALSE
+"H1650","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.40139,1.17,0.222,3889,1,"CCL5, TLR1, IFNA5, TLR6, STAT1, IRF3, MAPK11, MAP2K1, IL6, IFNB1, CD40, IL12A, AKT2, RAC1, MAP3K8, MYD88, TAB2, IL12B, CD14, MAPK13, TLR3, TIRAP, MAPK3, CASP8, PIK3R3, AKT3, TICAM2",0.653647025549361,0,FALSE
+"H1650","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.20627,-0.769,0.805,16293,0.908,"IDO1, AOC1, AFMID, EHHADH, MAOB, ALDH1B1, KYNU, ALDH2, TPH1, MAOA, WARS2",0.0942041196321315,0.0419141514789149,FALSE
+"H1650","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.19465,-0.728,0.868,15050,0.947,"CACNA1A, SLC2A4, PIK3CG, MAPK8, CACNA1B, PIK3R1, PIK3CD, CACNA1G, TNF, CACNA1C, GCK, IRS2, KCNJ11, IRS1, INSR, IKBKB",0.0614802748235081,0.0236500209967266,FALSE
+"H1650","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.21764,0.636,0.945,2786,1,"IL12A, IL12B, GAD1",0.0245681914907371,0,FALSE
+"H1650","Input","KEGG_TYROSINE_METABOLISM",-0.16285,-0.6,0.988,18363,1,"FAH, METTL2B, MAOA, GSTZ1",0.00524305541237188,0,FALSE
+"H1650","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31339,0.915,0.573,5345,0.947,"CHP1, PAK4, CBLC, PPP3R1, MAPK11, MAP2K1, PPP3CA, VAV3, NFAT5, MAP3K14, AKT2, MALT1, VAV1, MAP3K8, NFATC1, NFKBIB, MAPK13, PAK6, NFATC3, VAV2, MAPK3, PIK3R3, AKT3, RAF1, SOS1, PTPN6, GRB2, RHOA, FOS, PAK2, CDC42",0.24184537803261,0.0236500209967266,FALSE
+"H1650","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.41684,1.22,0.163,5940,0.972,"FBXO2, UBE2D4, SIAH1, FBXW7, UBR5, CBLC, WWP2, UBE2G1, HUWE1, ITCH, NEDD4L, UBE2E2, UBA2, UBE2L6, HERC3, SOCS1, ANAPC2, UBA7, SAE1, UBE2M, CUL2, UBE2E1, UBE2S, ANAPC10, CDC23, MID1, FANCL, WWP1, UBE4B, NHLRC1, PIAS1, HERC1, UBE2C, UBE2G2, UBE2D3, SKP2, RBX1, UBE3B, ANAPC7, UBE3A, NEDD4, KEAP1, FBXW8, UBE2K, CDC20, UBE2R2, UBE2Z, ELOC, PML, TRIP12, BIRC6, FBXO4, UBE2H, BRCA1, CUL1, BIRC2, UBE2B, SMURF1",0.787812395596042,0.0123337350737254,FALSE
+"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.43174,1.24,0.163,6890,0.99,"PDHA1, PDHB, BCAT2, IARS2",0.787812395596042,0.00436480540245009,FALSE
+"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.28153,0.826,0.756,7002,0.989,"ABAT, ACAA1, BCKDHA, HIBADH, ACAD8, MCEE, AOX1, ECHS1, HADHA, OXCT1, HMGCS1, MCCC2, ALDH3A2, ACAT2, HSD17B10, HADHB, ALDH9A1, ACAA2, BCAT2, MCCC1, OXCT2",0.121478204498793,0.0048037084028206,FALSE
+"H1650","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.31606,0.925,0.591,4851,0.958,"ADORA2A, CALM3, MYL9, GNAS, CACNA1D, MAP2K1, PRKCD, PLA2G12A, ARHGEF1, KCNMB4, ADRA1B, PLA2G4B, GNAQ, PRKACG, ADCY1, MYLK2, NPR1, PPP1CB, ADCY7, KCNMA1, MAPK3, ADORA2B, PRKACA, KCNMB3, ITPR2, RAF1, GUCY1B1, PRKCE, CALML6, GUCY1A1, GNA12, CALM1, ADCY6, RHOA",0.228412519118745,0.0186344909214556,FALSE
+"H1650","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33906,0.974,0.502,6295,0.989,"DYNC1LI2, GNAS, DCTN1, DCTN5, DYNLL2, PRKACG, ARHGDIB, RAB11A, PRKACA, DYNC1H1, AQP3, RAB5C, ADCY6, CREB3, RAB5A, DYNLL1, STX4, PRKACB, CREB3L1",0.299296282854981,0.0048037084028206,FALSE
+"H1650","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.41642,1.23,0.169,3976,0.999,"CHP1, HSPB1, PPP3R1, MAPK11, MAP2K1, PPP3CA, PLCG2, PTK2, PLA2G12A, NFAT5, PXN, AKT2, PLA2G4B, SPHK2, MAPKAPK3, RAC1, NFATC1, MAPK13, NFATC3, MAPK3, PIK3R3, AKT3, BAD, RAF1",0.772113295386326,0.000434511774017692,FALSE
+"H1650","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.42622,1.24,0.169,5632,0.99,"ATP6V0D1, ERO1A, GNAS, ATP6V1C1, PLCG2, ACTB, TJP1, KDELR1, PRKACG, ATP6V0A1, ATP6V0C, PRKACA, TJP2, ATP6AP1, KDELR2, SEC61G, ARF1, ATP6V1B1, ATP6V0A4, PLCG1, ATP6V1E1, SEC61A2",0.772113295386326,0.00436480540245009,FALSE
+"H1650","Input","KEGG_VIRAL_MYOCARDITIS",0.50373,1.46,0.0401,2152,1,"MYH15, DAG1, ITGB2, MYH14, CYCS, ACTB, CD40, MYH3, BID, EIF4G1, CXADR, RAC1",1.39685562737982,0,FALSE
+"H1650","Input","KEGG_WNT_SIGNALING_PATHWAY",0.2983,0.86,0.693,4006,0.967,"CHP1, TCF7L1, CAMK2G, SIAH1, WNT9A, PPP2R1A, PPP3R1, PPP3CA, NFAT5, CSNK2A2, PPP2R5E, CTNNBIP1, WNT7B, RAC1, SMAD2, WNT7A, NFATC1, WNT6, CAMK2D, VANGL2, PRKACG, CCND3, FZD6, TCF7L2, FZD9, CTBP2, NFATC3, DAAM1, PRKACA, LRP5, FZD2, RBX1",0.159266765388193,0.0145735259169983,FALSE
+"HCC95","Input","KEGG_ABC_TRANSPORTERS",0.30702,1.01,0.428,1853,0.783,"ABCG1, ABCC1, ABCA4, ABCB6, ABCA13, TAP2, ABCC5",0.368556230986828,0.106238237942057,FALSE
+"HCC95","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.30346,0.985,0.449,4099,0.807,"EIF4EBP1, IKBKB, GRB2, BAD, PIK3CA, JUP, PIK3R2, CEBPA, MYC, LEF1, BRAF, PIK3CB, CCNA1, KRAS, PML, HRAS, MAPK1, PIM1, RUNX1, AKT2",0.347753658996677,0.0931264652779296,FALSE
+"HCC95","Input","KEGG_ADHERENS_JUNCTION",0.27962,0.927,0.52,5098,0.866,"NECTIN1, RAC3, YES1, NLK, PTPN6, EGFR, SNAI2, LEF1, CDH1, CSNK2A2, MET, MAP3K7, IGF1R, WASF3, PTPRB, CSNK2A1, TJP1, MAPK1, SRC, PTPN1, SMAD2, TGFBR1, BAIAP2, RAC1, ERBB2",0.283996656365201,0.0624821079826534,FALSE
+"HCC95","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.44892,1.5,0.0581,4121,0.501,"ADIPOR1, ACSL6, ADIPOR2, POMC, IKBKB, CAMKK1, RXRA, IRS1, CPT1A, MAPK9, MAPK10, ACSL3, SLC2A4, NFKBIB, PRKAA1, PRKCQ, SLC2A1, ACACB, PRKAG2, MAPK8, TRADD, AKT2, CAMKK2",1.23582386760967,0.300162274132754,FALSE
+"HCC95","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.49111,1.62,0.0311,3522,0.454,"GLS2, GLUL, GOT2, ASNS, ALDH4A1, CAD, ASS1, GOT1, ALDH5A1, GPT2, GAD1",1.50723961097316,0.342944147142896,FALSE
+"HCC95","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.29786,0.987,0.438,3156,0.812,"ATP1B3, SFN, SCNN1A, PIK3CA, PIK3R2, IRS1, ATP1A1, PIK3CB, KRAS",0.3585258894959,0.0904439707588247,FALSE
+"HCC95","Input","KEGG_ALLOGRAFT_REJECTION",0.21337,0.694,0.896,15037,1,"CD40, CD86, IL12A, FAS, IFNG, CD40LG, IL2, CD28, FASLG, IL12B, GZMB, CD80, IL4, PRF1, IL10, TNF, IL5",0.0476919903378748,0,FALSE
+"HCC95","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.33598,1.09,0.311,2278,0.708,"FADS2, PLA2G4B, PLA2G4A, PLA2G12A",0.507239610973163,0.149966742310231,FALSE
+"HCC95","Input","KEGG_ALZHEIMERS_DISEASE",0.2159,0.709,0.876,4348,1,"CALML3, NDUFB5, NDUFB7, PPP3R2, NOS1, SNCA, GAPDH, NDUFS6, BAD, ATP5MC1, ATP5PD, PLCB1, NDUFA9, COX5A, ITPR3, NDUFV2, ATP2A3, NDUFB10, CAPN1, NAE1, NDUFA4L2, IL1B, BID, UQCRFS1, ADAM17, SDHD, NDUFA2, ATP2A2, SDHA, MAPK1, NDUFS4, NDUFA8, CDK5, PLCB3, CACNA1D, COX7C",0.0574958938319193,0,FALSE
+"HCC95","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.39923,-1.49,0.0692,16276,0.356,"PARS2, LARS2, TARS2, FARSA, PSTK, CARS2, YARS2, FARS2",1.15989390554324,0.448550002027125,FALSE
+"HCC95","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.33085,-1.27,0.114,16584,0.473,"FPGT, HK2, RENBP, GNE, GMDS, GALE, GMPPA, GALT, PGM1, PMM1, UAP1, NAGK",0.943095148663527,0.325138859262188,FALSE
+"HCC95","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.37768,1.23,0.188,2891,0.575,"CAT, NEFL, PPP3R2, CASP1, NOS1, BCL2, NEFM, BAD, MAPK13, DAXX, MAPK12, MAP2K6, BID",0.72584215073632,0.24033215531037,FALSE
+"HCC95","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.26382,0.858,0.656,4226,0.895,"CANX, HSP90AB1, HSPA1B, RFXANK, PSME3, TAP2, RFXAP, IFI30, CD8A, KIR2DL3, TAP1, TAPBP, HSPA4, PDIA3",0.18309616062434,0.048176964684088,FALSE
+"HCC95","Input","KEGG_APOPTOSIS",0.23221,0.761,0.8,3028,0.985,"IL1A, IL1RAP, PPP3R2, IKBKB, BCL2, NGF, BAD, PIK3CA, PIK3R2, PRKACA, ENDOD1, ENDOG, CAPN1, TNFSF10, IL1B, BID, PIK3CB",0.0969100130080564,0.00656376950238827,FALSE
+"HCC95","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.46762,1.56,0.0455,2278,0.467,"CYP4F3, AKR1C3, GPX2, ALOX12B, PTGES2, GPX3, CBR1, EPHX2, CBR3, PLA2G4B, LTC4S, TBXAS1, PLA2G4A, PLA2G12A",1.34198860334289,0.330683119433888,FALSE
+"HCC95","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.41436,1.37,0.109,3357,0.508,"GLS2, PYCR2, GLUL, CKMT1B, CKMT1A, NOS1, GOT2, PYCR1, ALDH3A2, ALDH4A1, ASS1, NOS2, GOT1, GAMT, GATM, PYCR3, OAT, CKB, ALDH2",0.962573502059376,0.294136287716081,FALSE
+"HCC95","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.18401,0.593,0.978,3704,0.998,"CACNA2D3, CACNG4, JUP, ITGB4, PKP2, ITGA2, LEF1, CACNB1, DSG2, ITGA6, ITGA2B, CDH2, SLC8A1, ATP2A2, GJA1",0.00966114521239857,0.000869458712628891,FALSE
+"HCC95","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.43946,-1.56,0.063,18925,0.499,"ALDH9A1, ALDH7A1",1.20065945054642,0.30189945437661,FALSE
+"HCC95","Input","KEGG_ASTHMA",0.23332,0.763,0.783,622,0.99,"EPX",0.106238237942057,0.00436480540245009,FALSE
+"HCC95","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.23195,-0.838,0.656,8962,0.994,"IFNA4, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, CD28, FASLG, TPO, GZMB, TSHB, CD80, IFNA13, IL4, CTLA4, PRF1, IL10, IFNA21, CGA, IFNA1, IFNA5, TSHR, IL5",0.18309616062434,0.00261361560268669,FALSE
+"HCC95","Input","KEGG_AXON_GUIDANCE",0.22644,0.744,0.834,3156,0.973,"PAK2, SEMA4D, RAC3, PPP3R2, EFNB1, SEMA4A, SEMA3F, NTN1, EFNB3, EPHA1, DPYSL5, EPHB4, SEMA4F, PAK6, NCK1, UNC5B, GNAI1, NFATC1, PAK1, ABLIM1, EPHA8, EPHB3, RHOD, EPHB6, MET, SEMA4B, KRAS",0.0788339493622613,0.0118871597316481,FALSE
+"HCC95","Input","KEGG_BASAL_CELL_CARCINOMA",0.55164,1.8,0.0119,2279,0.357,"WNT3A, FZD1, WNT5A, WNT8B, GLI2, FZD10, DVL3, WNT10A, SMO, WNT7B, WNT11, WNT10B, FZD9, WNT9A, AXIN1, PTCH1, WNT7A, WNT16, WNT4, LEF1",1.92445303860747,0.447331783887807,FALSE
+"HCC95","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.39984,1.31,0.122,5303,0.537,"STON1, TAF6, TAF11, GTF2H4, GTF2F2, TAF4B, GTF2IRD1, GTF2H3, TAF7, TAF5L, TAF6L, GTF2A2, TAF4, TAF9B, GTF2I, TAF1, GTF2H2, GTF2A1L, TAF5",0.913640169325252,0.270025714300444,FALSE
+"HCC95","Input","KEGG_BASE_EXCISION_REPAIR",0.37934,1.25,0.18,2468,0.582,"POLB, UNG, PCNA, FEN1, POLE2, POLD2, POLE3, PARP1, HMGB1, NTHL1",0.744727494896694,0.235077015350112,FALSE
+"HCC95","Input","KEGG_BETA_ALANINE_METABOLISM",-0.34586,-1.24,0.169,17649,0.465,"DPYD, ACADM, ALDH9A1, SMS, ALDH7A1",0.772113295386326,0.332547047110046,FALSE
+"HCC95","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.36381,1.2,0.182,2850,0.606,"TECR, SCD, FADS2, FADS1, HADHA, ELOVL5, SCD5",0.739928612014925,0.217527375833714,FALSE
+"HCC95","Input","KEGG_BLADDER_CANCER",-0.25625,-0.889,0.549,16469,0.922,"MDM2, MMP1, RAF1, DAPK3, TYMP, DAPK1, CDKN2A, RASSF1, ARAF",0.260427655549908,0.0352690789463706,FALSE
+"HCC95","Input","KEGG_BUTANOATE_METABOLISM",0.33926,1.12,0.27,3522,0.716,"AKR1B10, HMGCS1, EHHADH, ALDH3A2, BDH1, L2HGDH, HADHA, ACAT2, ALDH5A1, OXCT1, ALDH2, GAD1",0.568636235841013,0.145086977692144,FALSE
+"HCC95","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.25356,0.823,0.696,3328,0.93,"SYK, RAC3, PPP3R2, IKBKB, PTPN6, GRB2, PIK3CA, PIK3R2, LYN, NFATC1, IFITM1, MALT1, NFKBIB, PIK3CB, KRAS, FOS, HRAS",0.157390760389438,0.0315170514460649,FALSE
+"HCC95","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.23852,0.789,0.763,2808,0.966,"CALML3, VDAC3, ADCY3, PPP3R2, NOS1, CHRNA7, VDAC2, ADRA1A, EGFR, PLCB1, PHKB, ADORA2B, ADCY1, GNAL, CAMK4, GNA15, PRKACA, PTAFR, ADRB2, ATP2B4, ITPR3, ATP2A3, CHRM3, PLCD1, TACR1, NOS2, HTR2C",0.11747546204512,0.0150228735845067,FALSE
+"HCC95","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.19759,0.642,0.939,5223,0.995,"TNNI3, CACNA2D3, ATP1B3, CACNG4, COX5A, ATP1A1, CACNB1, UQCRFS1, SLC8A1, ATP2A2, CACNA1D, COX7C, MYL2, TPM4, COX5B, CYC1, UQCRHL, UQCRC1, COX8A",0.0273344077338891,0.00217691925427455,FALSE
+"HCC95","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.18793,0.621,0.954,3590,0.989,"CLDN8, CLDN11, NECTIN1, CNTN1, SDC1, CDH3, CNTNAP2, JAM3, CLDN4, CLDN7, CDH1, ITGA6, CLDN1, F11R, CD8A, ICOSLG, CDH2, NEO1, CD40",0.0204516252959049,0.0048037084028206,FALSE
+"HCC95","Input","KEGG_CELL_CYCLE",0.33735,1.09,0.323,5745,0.708,"YWHAG, MCM7, ANAPC1, CCNB2, SFN, MCM3, CDC6, SKP2, E2F4, TFDP1, ORC3, MCM4, ANAPC11, PCNA, GADD45G, ORC5, MYC, RB1, CDC23, CCND2, CCND3, CDC45, CUL1, RBL1, BUB1, CDC26, TFDP2, CCNA1, PKMYT1, BUB1B, DBF4, CDC14B, CDC25C, STAG1, CCNA2, TGFB2, CHEK1, PTTG1, MAD2L2, ANAPC7, HDAC1, CDC27, SMAD2, CDKN1B, ATR, PTTG2, CCND1, PRKDC, SKP1, CCNB1, TTK, CREBBP, E2F2, PLK1, BUB3, MAD2L1, ANAPC4, MCM6",0.490797477668897,0.149966742310231,FALSE
+"HCC95","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.23257,0.763,0.797,3156,0.99,"GRK7, CXCR2, ADCY3, GRK6, ELMO1, IKBKB, GRB2, GNB2, GNG4, CCL19, CX3CL1, XCL2, PIK3CA, PIK3R2, PLCB1, ADCY1, CCL26, LYN, PRKACA, GNAI1, PAK1, GNB4, NFKBIB, CXCL14, BRAF, GNB5, CXCL16, ARRB2, PIK3CB, KRAS",0.0985416786038876,0.00436480540245009,FALSE
+"HCC95","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.20635,0.678,0.916,4942,1,"IKBKB, GRB2, BAD, PIK3CA, PIK3R2, MYC, RB1, BCR, BRAF, CBLC, PIK3CB, KRAS, HRAS, CRKL, TGFB2, MAPK1, RUNX1, AKT2, HDAC1, MECOM, CDKN1B, TGFBR1, SHC1, CCND1",0.0381045263321496,0,FALSE
+"HCC95","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.57348,-2.05,0.00722,15139,0.157,"BHLHE41, CRY1, PER1, NR1D1, NPAS2, CLOCK, CRY2",2.14146280243036,0.804100347590766,TRUE
+"HCC95","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.35315,-1.29,0.151,17455,0.509,"ACO2, SDHC, PDHB, ACO1, SUCLG1, IDH3G, SUCLG2, PDHA1",0.821023052706831,0.293282217663241,FALSE
+"HCC95","Input","KEGG_COLORECTAL_CANCER",0.28377,0.917,0.529,5155,0.862,"RAC3, BCL2, BAD, PIK3CA, PIK3R2, MSH6, AXIN1, MAPK9, MYC, MAPK10, LEF1, BRAF, PIK3CB, KRAS, FOS, TGFB2, BIRC5, MAPK1, MAPK8, AKT2, SMAD2, TGFBR1, CCND1, RAC1, MSH2",0.276544327964814,0.0644927341752872,FALSE
+"HCC95","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.1956,-0.717,0.85,11767,1,"C9, C5AR1, C2, SERPINF2, FGB, F2, MASP1, C4BPA, F13A1, CFI, SERPINC1, F7, A2M, FGG, C7, SERPIND1, F10, F5, C3, PLG, CD55, MASP2, SERPINA5, C3AR1, C4BPB, SERPINA1, KLKB1, CD59, PLAUR, SERPING1, F2R, THBD, C4A, C8G, PROS1, C4B, CFB, TFPI",0.0705810742857073,0,FALSE
+"HCC95","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.43542,1.44,0.0814,1547,0.498,"APIP, LDHC, GOT2, MAT2B, AHCY, ENOPH1",1.0893755951108,0.302770657240282,FALSE
+"HCC95","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.12362,0.407,1,3613,1,"CXCR2, BMP7, FLT4, IL1A, IL1RAP, NGFR, PDGFA, EDAR, CCL19, CX3CL1, EGFR, XCL2, CCL26, IFNLR1, LTB, IL17RA, IL22RA1, TNFSF10, CXCL14, LTBR, IL1B, CXCL16, MET, TNFRSF21, PDGFB, TNFSF18, IL20RB, TNFSF15, IL10RB, CD40, TGFB2",0,0,FALSE
+"HCC95","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.18491,-0.67,0.913,18304,0.995,"TBK1, DDX58, POLR3C, RIPK1",0.039529222465701,0.00217691925427455,FALSE
+"HCC95","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.18254,-0.647,0.953,14293,0.972,"TNF, IGF1, ADCY5, CACNG7, SGCD, LAMA2, LMNA, SGCA, TNNC1, CACNB2, DES, RYR2, ITGA9, CACNA2D1, ADCY4, ITGA10, ITGB7, ITGB5, CACNA1C, DMD, CACNA2D4, CACNG6, PRKACB, CACNG8, ITGA7, ITGA1, ITGB3, ITGB1, ADCY6, ACTB, TGFB3, TPM2",0.0209070993616736,0.0123337350737254,FALSE
+"HCC95","Input","KEGG_DNA_REPLICATION",0.61576,2.01,0.00409,4130,0.709,"RFC4, MCM7, MCM3, RFC2, MCM4, PCNA, RNASEH2B, FEN1, POLE2, POLD2, POLE3, RFC3, RPA3, PRIM1, SSBP1, RPA1, POLA2, RFC5, RNASEH2C, DNA2, PRIM2",2.38827669199266,0.149353764816933,FALSE
+"HCC95","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.24456,0.8,0.757,3940,0.952,"GRB2, ETV7, EGFR, KRAS, SPIRE2, MAPK1, NOTCH1",0.120904120499927,0.0213630516155257,FALSE
+"HCC95","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.32068,1.04,0.366,2955,0.769,"ADH7, ALDH3A1, UGT2B17, GSTM3, GSTP1, ADH5, GSTA4, GSTA1",0.436518914605589,0.114073660198569,FALSE
+"HCC95","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.34161,1.14,0.269,1986,0.691,"GMPS, TPMT, IMPDH1, TK1, UGT2B17, HPRT1, CES1",0.570247719997592,0.160521952625802,FALSE
+"HCC95","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.25009,0.813,0.73,3315,0.942,"LAMA1, VWF, CD44, COL4A6, SDC1, ITGB4, LAMC2, ITGA2, SPP1, LAMB3, SV2A, ITGA6, ITGA2B, THBS4, GP1BA, LAMA3",0.136677139879544,0.0259490972071227,FALSE
+"HCC95","Input","KEGG_ENDOCYTOSIS",0.25311,0.833,0.7,3027,0.917,"GRK7, TRAF6, CXCR2, FGFR2, GRK6, ACAP2, PRKCI, RAB4A, EPN3, AP2M1, FGFR3, TFRC, MVB12A, GIT1, HSPA1B, SNF8, CHMP6, VPS4B, EGFR, AP2B1, SH3GL3, PIP4K2B, ADRB2, RAB5C, CLTCL1, PLD1, RAB31, RUFY1, RAB11FIP1, ITCH, CHMP1B, CBLC, ARAP3, MET, ARRB2, VPS25",0.154901959985743,0.0376306643299789,FALSE
+"HCC95","Input","KEGG_ENDOMETRIAL_CANCER",-0.25355,-0.912,0.571,16363,0.925,"PIK3R3, PIK3R1, SOS1, RAF1, AXIN2, TCF7, TCF7L2, ILK, SOS2, GSK3B, ELK1, ARAF",0.243363891754152,0.0338582672609674,FALSE
+"HCC95","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.3968,1.3,0.148,5491,0.543,"CXCR2, ATP6V1C2, PTPRZ1, ATP6V1E2, GIT1, IKBKB, EGFR, JAM3, MAPK13, LYN, MAPK9, PAK1, MAPK10, MAPK12, MET, F11R, ADAM17, HBEGF, ATP6V0A2, TJP1, MAPK8, ATP6V1G2, SRC, MAPK14, MAPK11, ATP6V0C, ATP6V0E2, RAC1, PLCG2, ATP6AP1, CSK, MAP3K14, IKBKG, ADAM10",0.829738284605043,0.265200170411153,FALSE
+"HCC95","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.29124,0.948,0.49,4125,0.863,"NRG1, PAK2, NRG4, EIF4EBP1, GRB2, EGFR, BAD, PIK3CA, PIK3R2, PAK6, NCK1, MAPK9, MYC, PAK1, MAPK10, BRAF, CBLC, PIK3CB, KRAS, HBEGF, HRAS, CRKL, NCK2, MAPK1, MAPK8, PAK4, SRC, AKT2, CAMK2G",0.309803919971486,0.0639892042847904,FALSE
+"HCC95","Input","KEGG_ETHER_LIPID_METABOLISM",0.30781,1,0.43,3292,0.788,"PLA2G4B, PLD1, PLA2G4A, PLA2G12A, PLPP1, PLPP2, PAFAH1B2, LPCAT2",0.366531544420413,0.103473782510445,FALSE
+"HCC95","Input","KEGG_FATTY_ACID_METABOLISM",0.35809,1.18,0.23,3440,0.641,"ADH7, ACSL6, EHHADH, ALDH3A2, ECI1, CPT1A, ACSL3, HADHA, ADH5, ACAT2, ALDH2, HADHB",0.638272163982407,0.193141970481183,FALSE
+"HCC95","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.26261,0.842,0.675,4493,0.914,"SYK, RAC3, GRB2, PIK3CA, PIK3R2, PLA2G4B, MAPK13, LYN, MAPK9, PLA2G4A, MAPK10, PLA2G12A, MAPK12, MAP2K6, PIK3CB, KRAS, HRAS, MAPK1, MAPK8, AKT2, MAPK14, MAPK11, VAV2",0.170696227168975,0.0390538042661686,FALSE
+"HCC95","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.24326,-0.873,0.575,15255,0.932,"PLCG1, PLPP3, PLA2G4F, AMPH, INPP5D, PIP5K1B, FCGR1A, FCGR2A, PIK3R3, PIK3R1, ARPC3, ARPC4, RAF1, DOCK2, PIP5K1C, PLA2G6, ARF6, CDC42, LAT, PRKCA, ASAP2, CFL2, DNM2, GAB2, PIP5K1A, VASP, DNM1L, MARCKSL1",0.24033215531037,0.0305840876460186,FALSE
+"HCC95","Input","KEGG_FOCAL_ADHESION",0.22127,0.727,0.853,4105,0.993,"PDGFD, LAMA1, VWF, PAK2, FLT4, RAC3, COL4A6, CAV1, PDGFA, BCL2, GRB2, CAV2, EGFR, BAD, PIK3CA, PIK3R2, ITGB4, LAMC2, ITGA2, DIAPH1, PAK6, MAPK9, SPP1, LAMB3, PAK1, MAPK10, CCND2, CCND3, BRAF, ITGA6, ITGA2B, MET, PIK3CB, THBS4, PDGFB, MYL12B, LAMA3, HRAS, IGF1R, PPP1CB, CRKL, LAMA5, MAPK1, MAPK8, PAK4, TNC, SRC, AKT2, COL4A1",0.069050968832477,0.00305075150461883,FALSE
+"HCC95","Input","KEGG_FOLATE_BIOSYNTHESIS",0.35829,1.17,0.222,4694,0.654,"DHFR, SPR, GGH",0.653647025549361,0.184422251675733,FALSE
+"HCC95","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.36988,1.21,0.198,5217,0.609,"AKR1B10, ALDOC, TPI1, SORD, KHK, MPI, AKR1B1, MTMR1, PFKM, HK1, PFKFB2, MTMR2, ALDOA, FBP2",0.703334809738469,0.215382707367125,FALSE
+"HCC95","Input","KEGG_GALACTOSE_METABOLISM",0.26782,0.874,0.637,4310,0.885,"GLA, B4GALT2, GANC, AKR1B1, GAA, GCK, PFKM, GALK2, HK1",0.19586056766465,0.0530567293021746,FALSE
+"HCC95","Input","KEGG_GAP_JUNCTION",0.25971,0.86,0.652,4826,0.899,"PDGFD, ADCY3, PDGFA, GRB2, EGFR, PLCB1, ADCY1, PRKACA, GNAI1, ITPR3, HTR2C, LPAR1, TUBAL3, KRAS, PDGFB, HRAS, TUBA4A, MAP2K5, GJA1, TJP1, MAPK1, SRC, PLCB3, TUBB, PDGFC, GUCY1B1, ADCY9",0.18575240426808,0.0462403082667712,FALSE
+"HCC95","Input","KEGG_GLIOMA",0.22471,0.746,0.82,4125,0.978,"CALML3, PDGFA, GRB2, EGFR, PIK3CA, PIK3R2, RB1, BRAF, PIK3CB, KRAS, PDGFB, HRAS, IGF1R, MAPK1, AKT2, CAMK2G",0.0861861476162833,0.00966114521239857,FALSE
+"HCC95","Input","KEGG_GLUTATHIONE_METABOLISM",0.44028,1.44,0.0744,1394,0.498,"GCLC, GCLM, PGD, GPX2, GSR, G6PD, GPX3, GGCT, GSTM3",1.12842706445412,0.302770657240282,FALSE
+"HCC95","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.24477,-0.903,0.571,18025,0.916,"AGPAT4, LIPG, GK, MGLL, ALDH9A1, ALDH7A1",0.243363891754152,0.0381045263321496,FALSE
+"HCC95","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.41499,1.36,0.114,3494,0.481,"LPCAT3, DGKH, LCLAT1, PTDSS1, PCYT1A, GNPAT, PCYT2, PCYT1B, PLA2G4B, DGKE, PLD1, PLA2G4A, PLA2G12A, ETNK2, PEMT, PLPP1, CDS1, ETNK1, CDIPT, PLPP2, PGS1, CDS2, AGPAT3, LPCAT2, GPD2, DGKA",0.943095148663527,0.317854923626168,FALSE
+"HCC95","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.42973,1.4,0.0889,3249,0.502,"GNMT, AOC2, PIPOX, PSAT1, SHMT1, AOC3, GAMT, GATM, PHGDH, GCAT",1.05109823902979,0.299296282854981,FALSE
+"HCC95","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.39925,1.34,0.132,4582,0.508,"ADH7, LDHC, ALDH3A1, ALDOC, TPI1, GAPDH, ACSS1, GPI, ALDH3A2, BPGM, ACSS2, ADH5, DLAT, PGAM4, ALDH2, LDHB, ALDH1A3, PGAM1, GCK, PFKM, HK1, PKM, PCK2",0.87942606879415,0.294136287716081,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36743,1.2,0.195,5286,0.606,"B4GALT7, XYLT2, CHST14, CHST7, CHST15, B3GAT3, CHPF, CHSY1, CHST3, CHST12, B3GALT6",0.709965388637482,0.217527375833714,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.47807,1.57,0.0387,3874,0.48,"HS6ST1, B4GALT7, XYLT2, HS6ST2, HS3ST3B1, GLCE, NDST2, B3GAT3, NDST1, HS3ST3A1",1.41228903498109,0.318758762624413,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.56397,-2.05,0.00383,14254,0.157,"ST3GAL3, CHST4, CHST2, CHST6, B3GNT7, FUT8, B4GALT4, B4GALT3, ST3GAL1",2.41680122603138,0.804100347590766,TRUE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.38633,1.28,0.15,2073,0.544,"HPSE, HGSNAT, HS3ST3B1, HEXB, NAGLU",0.823908740944319,0.26440110030182,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.44391,1.42,0.11,2469,0.479,"SLC33A1, B4GALNT1, B3GALT4, HEXB, ST6GALNAC4",0.958607314841775,0.319664486585437,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.2793,0.915,0.556,1845,0.858,"GLA, FUT1, HEXB",0.254925208417942,0.0665127121512946,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.33183,-1.24,0.169,14254,0.465,"ST3GAL3, B3GALT2, FUT7, FUT9, FUT3, FUT4, B3GALT1, B3GALT5, ST3GAL6, B3GNT3, B4GALT4, B4GALT3",0.772113295386326,0.332547047110046,FALSE
+"HCC95","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.56763,1.85,0.0123,788,0.414,"PIGX, PIGS, PIGW, PIGU, PIGV, PIGN",1.9100948885606,0.382999658879101,FALSE
+"HCC95","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.32728,-1.14,0.262,17087,0.595,"GLYCTK, ACO2, ACO1, MTHFD2L, HYI",0.581698708680255,0.22548303427145,FALSE
+"HCC95","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28819,0.943,0.523,4347,0.845,"CALML3, ADCY3, GRB2, EGFR, PLA2G4B, MAPK13, PLCB1, ADCY1, MAPK9, PRKACA, PLD1, ITPR3, PLA2G4A, MAPK10, PLA2G12A, MAPK12, MAP2K6, KRAS, HBEGF, HRAS, MMP14, MAPK1, MAPK8, SRC, CAMK2G, PLCB3, MAPK14, CACNA1D, ATF4, MAPK11",0.281498311132726,0.0731432910503077,FALSE
+"HCC95","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.32068,1.04,0.382,4253,0.769,"IL1A, IL1B, KIR2DL3, CD86",0.417936637088291,0.114073660198569,FALSE
+"HCC95","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.55523,1.83,0.0096,2277,0.366,"WNT3A, BMP7, WNT5A, WNT8B, GLI2, WNT10A, SMO, WNT7B, WNT11, FBXW11, WNT10B, WNT9A, PTCH1, WNT7A, WNT16, PRKACA, WNT4, CSNK1A1",2.01772876696043,0.436518914605589,FALSE
+"HCC95","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.19165,0.634,0.963,3166,0.994,"CD44, IL1A, CD1D, TFRC, CD9, ITGA2, ITGA6, IL1B, CD1E, ITGA2B, CD8A, GP1BA",0.0163737128754655,0.00261361560268669,FALSE
+"HCC95","Input","KEGG_HISTIDINE_METABOLISM",0.2761,0.892,0.589,1399,0.859,"ALDH3A1, BUD23, METTL2B, ALDH3A2",0.229884705212898,0.0660068361687577,FALSE
+"HCC95","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.46057,1.47,0.0726,3916,0.509,"SEM1, RAD51, EME1, POLD2, XRCC3, RPA3, BLM, SSBP1, RPA1, RAD51B, RAD51C, RAD51D, XRCC2",1.13906337929991,0.293282217663241,FALSE
+"HCC95","Input","KEGG_HUNTINGTONS_DISEASE",0.20404,0.669,0.928,2542,0.999,"HAP1, VDAC3, POLR2H, NDUFB5, NDUFB7, POLR2J, AP2M1, VDAC2, NRF1, NDUFS6, AP2B1, ATP5MC1, ATP5PD, PLCB1, POLR2G, NDUFA9, SIN3A, COX5A, TAF4B, CLTCL1, NDUFV2, NDUFB10, NDUFA4L2",0.0324520237811379,0.000434511774017692,FALSE
+"HCC95","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.21308,-0.777,0.737,14891,0.993,"SGCD, LAMA2, LMNA, SGCA, PRKAB1, TNNC1, CACNB2, DES, RYR2, ITGA9, CACNA2D1, ITGA10, ITGB7, ITGB5, CACNA1C, DMD, CACNA2D4, CACNG6, CACNG8, PRKAA2, ITGA7, ITGA1, ACE, ITGB3, ITGB1, ACTB, TGFB3, TPM2",0.132532512140949,0.00305075150461883,FALSE
+"HCC95","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.21705,-0.789,0.735,17006,0.996,"ALDH6A1, PIK3C2A, PIP5K1C, PI4KA, SYNJ1, INPPL1, PIK3C3, PIP4K2A, PIP5K1A, PI4KB",0.133712660915805,0.00174066157630127,FALSE
+"HCC95","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.29416,0.954,0.5,4615,0.867,"CALML3, PRKCI, ACACA, EIF4EBP1, IKBKB, GRB2, SREBF1, BAD, PIK3CA, PIK3R2, PHKB, IRS1, MAPK9, PRKACA, SOCS1, MAPK10, FLOT2, SLC2A4, FOXO1, RHEB, BRAF, PRKAA1, CBLC, FASN, PIK3CB, KRAS, EXOC7, HRAS, PHKA1, ACACB, PPP1CB, CRKL, PRKAG2, SH2B2, RPTOR, MAPK1, MAPK8, GCK, AKT2, PYGL, HK1, PRKCZ, PTPN1, PCK2, RAPGEF1",0.301029995663981,0.0619809025237897,FALSE
+"HCC95","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.18783,-0.688,0.919,11300,1,"CD80, PIGR, TNFSF13, IL4, AICDA, IL10, CCR9, CCL25, TNFRSF13C, IL6, CXCL12, IL5, CCR10, ITGB7, TNFSF13B, CXCR4, IL15, CCL28",0.0366844886138887,0,FALSE
+"HCC95","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.20593,-0.755,0.817,16363,1,"PIK3R3, PIK3R1, CSF2RA, IL3RA, CNTF, SOS1, IL15, IL11RA, STAT1, IL6ST, PIAS3, SPRY4, JAK2, LIF, SPRY2, SPRY3, IL11, STAM, JAK1, SOCS4, CLCF1, TYK2, IRF9, SOS2, STAT2, STAT5A",0.0877779434675845,0,FALSE
+"HCC95","Input","KEGG_LEISHMANIA_INFECTION",0.24501,0.806,0.742,4896,0.949,"TRAF6, IL1A, PTPN6, MAPK13, MAPK12, NFKBIB, NOS2, IL1B, MAP3K7, FOS, TGFB2, MAPK1, MAPK14, PTGS2, MAPK11, NCF2, IL12A, ITGB2",0.129596094720973,0.0227337875727074,FALSE
+"HCC95","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.2144,-0.828,0.72,13995,0.988,"ESAM, VAV3, VCL, CXCL12, CLDN14, CTNNA2, CLDN2, CDH5, MYL5, ARHGAP5, CLDN15, VCAM1, PRKCG, RAPGEF3, PLCG1, CLDN10, JAM2, CYBB, PIK3R3, PIK3R1, CXCR4, CLDN9, GNAI3, RHOA, MYLPF, ROCK1, AFDN, EZR, TXK, CD99, CDC42, ITGB1, CLDN23, ACTB, PRKCA, BCAR1, RAP1B, RAP1A, MYL9, ICAM1, ROCK2, VASP, CYBA",0.142667503568732,0.00524305541237188,FALSE
+"HCC95","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.45478,-1.69,0.0278,18062,0.514,"YOD1, ALDH9A1, ALDH7A1",1.55595520408192,0.289036881004724,FALSE
+"HCC95","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.27548,0.896,0.576,2278,0.858,"AKR1B10, PLA2G4B, PLA2G4A, PLA2G12A",0.239577516576788,0.0665127121512946,FALSE
+"HCC95","Input","KEGG_LONG_TERM_DEPRESSION",0.22976,0.776,0.798,3896,0.983,"PPP2CA, NOS1, GNA13, PLA2G4B, PLCB1, LYN, GNAI1, ITPR3, PLA2G4A, PLA2G12A, BRAF, KRAS, HRAS, IGF1R, GNAZ, MAPK1, PPP2R1B",0.0979971086492706,0.00744648216786438,FALSE
+"HCC95","Input","KEGG_LONG_TERM_POTENTIATION",0.20946,0.692,0.907,4481,1,"CALML3, PPP3R2, PLCB1, ADCY1, CAMK4, PRKACA, ITPR3, RPS6KA1, BRAF, KRAS, HRAS, PPP1CB, MAPK1, CAMK2G, PLCB3, ATF4, CHP1",0.0423927129399047,0,FALSE
+"HCC95","Input","KEGG_LYSINE_DEGRADATION",0.2755,0.906,0.55,3357,0.871,"NSD3, EHHADH, PIPOX, ALDH3A2, NSD1, HADHA, EHMT2, NSD2, ACAT2, SETDB2, ALDH2",0.259637310505756,0.0599818449923368,FALSE
+"HCC95","Input","KEGG_LYSOSOME",0.21187,0.695,0.908,5662,1,"PSAPL1, AP3M2, SLC11A1, M6PR, ARSG, CTSV, LAMP3, AP3B1, GLA, HGSNAT, AP1S1, HEXB, LIPA, NAGLU, CLTCL1, GM2A, CD68, NAGPA, CTSH, AP3B2, GNPTAB, LAMP1, CLN5, AP3M1, PPT1, ATP6V0A2, AP1S3, NPC1, GAA, DNASE2, AP1M2, ATP6V0C, LAPTM4B, ABCA2, CTSZ, HEXA, NAGA, GGA2, CLTB, ATP6AP1, NPC2, CTSB, CLTC, PPT2, CTSF, LGMN, CTSL",0.0419141514789149,0,FALSE
+"HCC95","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.27399,0.896,0.616,3498,0.858,"TRAF6, NTRK2, MAP3K13, MAP4K1, PAK2, NTF4, FGFR2, RAC3, IL1A, CACNA2D3, NF1, HSPB1, PPP3R2, NLK, FGFR3, IKBKB, PDGFA, DUSP14, GRB2, HSPA1B, NGF, CACNG4, EGFR, PLA2G4B, MAPK13, GADD45G, MAPK9, PPM1B, PRKACA, MYC, PAK1, PLA2G4A, FGF1, MAPK10, PLA2G12A, SRF, CACNB1, DAXX, MAPK12, MAP2K6, DUSP9, RPS6KA1, BRAF, FGF12, DUSP3, IL1B, JUND, ARRB2, MAP3K7, RPS6KA5, CACNA1B, KRAS, PDGFB, FOS, HRAS, TAOK1, RPS6KA4, MAP2K5, CRKL",0.210419287835575,0.0665127121512946,FALSE
+"HCC95","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26424,0.862,0.639,4735,0.903,"MAFA, ONECUT1, HHEX, MNX1, GCK, FOXA2, HES1",0.1944991418416,0.0443122496864942,FALSE
+"HCC95","Input","KEGG_MELANOGENESIS",0.43383,1.42,0.0828,2279,0.479,"CALML3, WNT3A, FZD1, ADCY3, WNT5A, WNT8B, FZD10, DVL3, WNT10A, POMC, WNT7B, EDN1, WNT11, WNT10B, FZD9, PLCB1, WNT9A, ADCY1, WNT7A, WNT16, PRKACA, GNAI1, WNT4, LEF1",1.08196966321512,0.319664486585437,FALSE
+"HCC95","Input","KEGG_MELANOMA",0.27659,0.918,0.542,3418,0.869,"PDGFD, PDGFA, EGFR, BAD, PIK3CA, PIK3R2, RB1, FGF1, CDH1, BRAF, FGF12, MET, PIK3CB, KRAS, PDGFB, HRAS, IGF1R",0.266000713461613,0.0609802235513335,FALSE
+"HCC95","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.53409,1.74,0.0201,1394,0.354,"ADH7, AKR1C2, ALDH3A1, AKR1C1, DHDH, AKR1C3, CYP2S1, CYP1B1, EPHX1, UGT2B17, GSTM3",1.69680394257951,0.450996737974212,FALSE
+"HCC95","Input","KEGG_MISMATCH_REPAIR",0.58449,1.92,0.00833,4009,0.387,"RFC4, RFC2, PMS2, MSH6, PCNA, POLD2, RFC3, RPA3, SSBP1, RPA1, RFC5, EXO1",2.07935499859321,0.412289034981089,FALSE
+"HCC95","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.30304,1,0.422,4169,0.788,"EIF4EBP1, DDIT4, PIK3CA, PIK3R2, ULK2, RHEB, RPS6KA1, BRAF, PRKAA1, PIK3CB, EIF4B, RPTOR, MAPK1, AKT2, MLST8",0.374687549038326,0.103473782510445,FALSE
+"HCC95","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.1681,0.562,0.99,3348,1,"SYK, RAC3, PPP3R2, ULBP1, MICB, PTPN6, GRB2, PIK3CA, PIK3R2, NFATC1, PAK1, MICA, TNFSF10, BRAF, LCK, BID, PIK3CB, KRAS, KIR2DL3, HRAS, ULBP3",0.00436480540245009,0,FALSE
+"HCC95","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.13459,0.44,1,2847,1,"P2RY1, ADRA2C, GABRB3, S1PR5, CHRNA7, CHRNB4, ADRA1A, CHRNA5, SSTR5, VIPR1, LPAR2, ADORA2B, PTAFR, ADRB2, MTNR1A, GRM4, P2RY13, CHRM3, TACR1, P2RY2, LPAR6, PTH2R, HTR2C, NMUR2, F2RL2, LPAR1",0,0,FALSE
+"HCC95","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.32583,1.07,0.321,4347,0.736,"CALML3, TRAF6, NTRK2, NTF4, YWHAG, NGFR, TP73, IKBKB, BCL2, GRB2, NGF, BAD, PIK3CA, PIK3R2, MAPK13, IRS1, CAMK4, MAPK9, MAPK10, MAPK12, NFKBIB, RPS6KA1, BRAF, PIK3CB, RPS6KA5, KRAS, HRAS, RPS6KA4, MAP2K5, CRKL, SH2B2, MAPK1, MAPK8, AKT2, CAMK2G, MAPK14, ATF4, MAPK11",0.493494967595128,0.133122185662501,FALSE
+"HCC95","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.37484,-1.33,0.142,16890,0.477,"AOX1, NMNAT2, NMNAT1, NT5E, NNT, NNMT, QPRT",0.847711655616944,0.321481620959886,FALSE
+"HCC95","Input","KEGG_NITROGEN_METABOLISM",0.38858,1.28,0.161,1305,0.544,"GLS2, GLUL, ASNS",0.79317412396815,0.26440110030182,FALSE
+"HCC95","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.33633,1.11,0.291,4347,0.717,"TRAF6, HSP90AB1, CASP1, IKBKB, MAPK13, MAPK9, MAPK10, TRIP6, MAPK12, NFKBIB, IL1B, PYCARD, MAP3K7, MAPK1, MAPK8, SUGT1, IL18, MAPK14, MAPK11",0.536107011014093,0.1444808443322,FALSE
+"HCC95","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.40163,-1.43,0.087,16335,0.404,"POLM, RAD50, NHEJ1, DCLRE1C, LIG4",1.06048074738138,0.393618634889395,FALSE
+"HCC95","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.20338,-0.744,0.789,14914,1,"MAP2K2, PRKCG, PLCG1, TP53, E2F3, PIK3R3, PIK3R1, SOS1, RAF1, FHIT, PRKCA, CDKN2A, SOS2, RASSF1, ARAF",0.10292299679058,0,FALSE
+"HCC95","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.23284,0.759,0.803,4735,0.98,"DLL1, DVL3, JAG2, MAML1, KAT2A, DLL3, JAG1, DVL2, DTX2, ADAM17, NOTCH1, HDAC1, MFNG, NUMBL, LFNG, HES1",0.095284454721319,0.00877392430750515,FALSE
+"HCC95","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.42598,1.39,0.117,3688,0.485,"RFC4, RAD23B, RFC2, GTF2H4, PCNA, POLE2, XPA, POLD2, POLE3, RFC3, RPA3, GTF2H3, RPA1, ERCC3, ERCC8, RFC5",0.931814138253838,0.314258261397736,FALSE
+"HCC95","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.42909,1.42,0.074,4377,0.479,"ALG3, ALG12, MOGS, DOLPP1, MGAT1, B4GALT2, TUSC3, ALG2, ALG1, ALG14, DPAGT1, GANAB, DPM1, STT3A, RFT1, MGAT4B, ALG5, ALG11, MAN1B1, ALG10B, MGAT2, RPN2",1.13076828026902,0.319664486585437,FALSE
+"HCC95","Input","KEGG_OLFACTORY_TRANSDUCTION",0.33325,1.1,0.307,458,0.731,"OR10S1, CALML3, OR11H4, OR8A1, OR8G1, OR1G1, OR10H2, OR8D2, OR6C70, ADCY3, OR8G5",0.512861624522813,0.13608262304214,FALSE
+"HCC95","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.30475,1.01,0.418,5546,0.783,"MTFMT, TYMS, SHMT1, DHFR, MTHFD2, SHMT2, MTHFD1L, GART, MTHFD1",0.378823718224965,0.106238237942057,FALSE
+"HCC95","Input","KEGG_OOCYTE_MEIOSIS",0.26634,0.875,0.609,4187,0.891,"CALML3, ADCY3, YWHAG, PPP3R2, ANAPC1, PPP2CA, CCNB2, FBXW11, PPP2R5D, ANAPC11, ADCY1, PRKACA, ITPR3, CDC23, MAPK12, CUL1, RPS6KA1, BUB1, CDC26, PKMYT1, CDC25C, IGF1R, PPP1CB, PTTG1, MAD2L2, MAPK1, PPP2R1B, CAMK2G, ANAPC7",0.215382707367125,0.0501222959631252,FALSE
+"HCC95","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.34108,-1.21,0.163,13292,0.489,"FUCA2, MAN2C1, NEU4, GLB1, FUCA1, NEU1, GBA, AGA, MAN2B1, MANBA",0.787812395596042,0.31069114087638,FALSE
+"HCC95","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.20225,0.661,0.925,6278,1,"ATP6V1C2, ATP6V1E2, NDUFB5, NDUFB7, NDUFS6, ATP5MC1, ATP5PD, NDUFA9, COX5A, NDUFV2, NDUFB10, NDUFA4L2, COX10, COX11, LHPP, UQCRFS1, SDHD, NDUFA2, ATP6V0A2, ATP5MG, SDHA, ATP6V1G2, NDUFS4, NDUFA8, COX7C, ATP6V0C, COX5B, ATP6V0E2, CYC1, UQCRHL, NDUFV1, ATP5PO, UQCRC1, COX8A, ATP6AP1, ATP5F1A, NDUFA10, UQCRQ, PPA1, NDUFB8, ATP12A, ATP5MF, COX15, NDUFB9, NDUFB2, COX7A2L, ATP6V0A1, ATP5MC3",0.0338582672609674,0,FALSE
+"HCC95","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.35234,1.15,0.259,2264,0.677,"GCNT1, GALNT11, GALNT18, GALNT13, GALNT14, GALNT12",0.586700235918748,0.169411331314856,FALSE
+"HCC95","Input","KEGG_P53_SIGNALING_PATHWAY",0.31099,1.02,0.392,977,0.788,"TP53AIP1, SESN3, SERPINB5, TP73, EI24, CCNB2, SFN",0.406713932979543,0.103473782510445,FALSE
+"HCC95","Input","KEGG_PANCREATIC_CANCER",0.28446,0.92,0.523,5488,0.874,"RAC3, IKBKB, RALBP1, RAD51, EGFR, BAD, PIK3CA, PIK3R2, MAPK9, PLD1, RB1, MAPK10, BRAF, PIK3CB, KRAS, TGFB2, MAPK1, MAPK8, AKT2, SMAD2, TGFBR1, TGFA, CCND1, RAC1, ERBB2, VEGFC, IKBKG, E2F2",0.281498311132726,0.058488567365597,FALSE
+"HCC95","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3738,1.24,0.178,3596,0.592,"COASY, PANK2, PPCDC, PANK3, BCAT1, BCAT2",0.749579997691106,0.22767829327708,FALSE
+"HCC95","Input","KEGG_PARKINSONS_DISEASE",0.19697,0.653,0.938,2542,0.993,"VDAC3, SNCAIP, NDUFB5, NDUFB7, SNCA, VDAC2, NDUFS6, ATP5MC1, ATP5PD, UCHL1, NDUFA9, COX5A, NDUFV2, NDUFB10, NDUFA4L2",0.0277971616209356,0.00305075150461883,FALSE
+"HCC95","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.41106,-1.52,0.0742,16465,0.412,"YWHAQ, ARPC3, CD14, RHOA, ARPC4, TLR4, TUBA1A, ROCK1, EZR, TUBA8, CDC42, ITGB1, ACTB, PRKCA, TUBB2B, TUBB2A, ROCK2, ARHGEF2",1.12959609472097,0.385102783966865,FALSE
+"HCC95","Input","KEGG_PATHWAYS_IN_CANCER",0.30119,1.01,0.411,3708,0.783,"TRAF6, WNT3A, LAMA1, FZD1, FGFR2, RAC3, WNT5A, WNT8B, GLI2, COL4A6, FZD10, DVL3, WNT10A, HSP90AB1, SMO, WNT7B, FGFR3, IKBKB, WNT11, PDGFA, BCL2, GRB2, RALBP1, SKP2, RAD51, WNT10B, EGFR, BAD, PIK3CA, JUP, RXRA, PIK3R2, FZD9, LAMC2, WNT9A, MSH6, AXIN1, ITGA2, PTCH1, WNT7A, WNT16, MAPK9, CEBPA, MYC, LAMB3, PLD1, WNT4, RB1, FGF1, MAPK10, LEF1, GSTP1, FOXO1, CDH1, BCR, BRAF, FGF12, ITGA6, NOS2, CBLC, FZD6, BID, ITGA2B, MET, SLC2A1, PIK3CB, CCNA1, DVL2, KRAS, PDGFB, PML, FOS, TRAF4, LAMA3, HRAS, IGF1R, CRKL, ARNT2, TGFB2, BIRC5, LAMA5, EGLN3",0.386158178123931,0.106238237942057,FALSE
+"HCC95","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.46084,1.52,0.0518,4360,0.488,"DHDH, DCXR, UGT2B17, AKR1B1, UGDH, RPEL1",1.28567024025477,0.311580177997289,FALSE
+"HCC95","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50449,1.66,0.036,1720,0.42,"ALDOC, PGD, G6PD, TKT, TALDO1, GPI, PGLS, DERA",1.44369749923271,0.3767507096021,FALSE
+"HCC95","Input","KEGG_PEROXISOME",0.33945,1.11,0.288,2716,0.717,"CAT, ACSL6, PEX6, EHHADH, GNPAT, PRDX1, SLC27A2, PEX11G, PEX5, PIPOX, PXMP2, EPHX2, PEX2, PAOX, PEX10, ACSL3, CROT, NOS2",0.540607512240769,0.1444808443322,FALSE
+"HCC95","Input","KEGG_PHENYLALANINE_METABOLISM",0.44089,1.47,0.0665,2780,0.509,"ALDH3A1, AOC2, GOT2, AOC3, GOT1",1.1771783546969,0.293282217663241,FALSE
+"HCC95","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25236,0.833,0.676,3123,0.917,"CALML3, DGKH, PIK3CA, PIK3R2, PLCB1, DGKE, PIP4K2B, IMPA2, ITPR3, IPPK, PLCD1, CDS1, CDIPT, PIK3CB, CDS2",0.170053304058364,0.0376306643299789,FALSE
+"HCC95","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.25238,-0.932,0.52,18193,0.94,"CPOX, UROD, HMOX1, PPOX, HCCS",0.283996656365201,0.0268721464003014,FALSE
+"HCC95","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.31381,1.04,0.371,3022,0.769,"ACSL6, ME1, SCD, EHHADH, FADS2, OLR1, SLC27A2, PLTP, RXRA, CPT1A, SLC27A5, ACSL3, FABP6, SCD5, SLC27A6",0.430626090384954,0.114073660198569,FALSE
+"HCC95","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.42226,-1.53,0.0579,15755,0.463,"CYP46A1, CYP7B1, CYP27A1, ACOX2, HSD3B7, SCP2",1.23732143627256,0.334419008982047,FALSE
+"HCC95","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.54243,1.77,0.0173,3590,0.353,"RAG1, RAG2, RFXANK, UNG, ADA, TAP2, RFXAP, LCK, CD8A, TAP1, CD40",1.7619538968712,0.452225294612177,FALSE
+"HCC95","Input","KEGG_PRION_DISEASES",-0.19563,-0.691,0.905,15964,1,"NCAM2, CCL5, PRKACB, NCAM1, C8G, HSPA1A, ELK1",0.0433514207947967,0,FALSE
+"HCC95","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.35234,1.15,0.244,4415,0.677,"ADCY3, HSP90AB1, ANAPC1, CCNB2, PIK3CA, PIK3R2, MAPK13, ANAPC11, ADCY1, MAPK9, PRKACA, GNAI1, MAPK10, CDC23, MAPK12, RPS6KA1, BRAF, BUB1, PIK3CB, CDC26, CCNA1, PKMYT1, KRAS, CDC25C, IGF1R, CCNA2, MAD2L2, MAPK1, MAPK8, AKT2, ANAPC7, MAPK14, MAPK11, CDC27",0.612610173661271,0.169411331314856,FALSE
+"HCC95","Input","KEGG_PROPANOATE_METABOLISM",0.31198,1.03,0.389,3769,0.773,"LDHC, EHHADH, ACACA, ACSS1, ALDH3A2, PCCB, ACSS2, HADHA, ACAT2, ALDH2, ACACB, LDHB",0.410050398674292,0.111820506081675,FALSE
+"HCC95","Input","KEGG_PROSTATE_CANCER",0.28298,0.934,0.524,3418,0.858,"PDGFD, FGFR2, HSP90AB1, IKBKB, PDGFA, BCL2, GRB2, EGFR, BAD, PIK3CA, PIK3R2, RB1, LEF1, GSTP1, FOXO1, BRAF, PIK3CB, KRAS, PDGFB, HRAS, IGF1R",0.280668713016273,0.0665127121512946,FALSE
+"HCC95","Input","KEGG_PROTEASOME",0.41552,1.36,0.112,5428,0.481,"PSMD11, PSMD2, SEM1, PSME3, PSMC5, PSMD12, PSMD3, PSMC2, PSMA4, PSMB3, PSMD8, PSMF1, PSME4, PSMC1, PSMB9, PSMA7, PSMB6, PSMB8, PSMB10, PSMA2, PSMD7",0.950781977329818,0.317854923626168,FALSE
+"HCC95","Input","KEGG_PROTEIN_EXPORT",-0.29128,-1.05,0.384,17904,0.729,"SRPRB, SEC61A2, SEC63, SEC61A1",0.415668775632469,0.137272471682025,FALSE
+"HCC95","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.47173,1.53,0.0629,2389,0.499,"GLS2, SLC9A3, ATP1B3, SLC25A10, MDH1, ATP1A1",1.20134935455473,0.30189945437661,FALSE
+"HCC95","Input","KEGG_PURINE_METABOLISM",0.23092,0.756,0.794,5795,0.977,"ADCY10, POLR2H, GMPS, ADCY3, IMPDH1, NME2, POLR2J, POLR1D, ADA, ADK, AK7, ADCY1, POLR2G, HPRT1, POLE2, POLD2, POLE3, POLR3G, PRIM1, PAICS, NT5C, POLR1B, POLA2, POLR2D, PDE8B, NT5M, PFAS, ITPA, PRIM2, ENTPD2, PKM, PDE9A, POLR3F, NME3, GUCY1B1, POLR2J2, ADCY9, NME1, ENTPD6, POLR1C, POLR2I, PPAT, POLD1, POLR2C, GART, CANT1, POLD3, POLR3GL, POLR2F, RRM1, AK4",0.100179497572904,0.0101054362812269,FALSE
+"HCC95","Input","KEGG_PYRIMIDINE_METABOLISM",0.27634,0.902,0.555,5758,0.862,"POLR2H, TK1, NME2, POLR2J, POLR1D, TXNRD1, TYMS, POLR2G, CAD, POLE2, POLD2, POLE3, POLR3G, DUT, PRIM1, NT5C, POLR1B, POLA2, POLR2D, NT5M, DTYMK, ITPA, PRIM2, DHODH, POLR3F, UPP1, NME3, POLR2J2, NME1, ENTPD6, POLR1C, POLR2I, POLD1, POLR2C, DCTD, CANT1, POLD3, POLR3GL, POLR2F, RRM1",0.255707016877324,0.0644927341752872,FALSE
+"HCC95","Input","KEGG_PYRUVATE_METABOLISM",0.33581,1.09,0.314,3776,0.708,"LDHC, ME1, ACACA, ACSS1, ALDH3A2, MDH2, MDH1, ACSS2, DLAT, ACAT2, AKR1B1, ALDH2, ACACB, LDHB, GLO1",0.503070351926785,0.149966742310231,FALSE
+"HCC95","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.19717,0.657,0.925,5149,0.997,"PDGFD, PAK2, FGFR2, RAC3, FGFR3, GIT1, FGD3, ENAH, PDGFA, GNA13, PFN2, EGFR, ARPC2, PIK3CA, PIK3R2, ITGB4, ITGA2, PIP4K2B, DIAPH1, PAK6, PAK1, FGF1, CHRM3, BRAF, FGF12, ITGA6, MYH14, ITGA2B, PIK3CB, KRAS, PDGFB, MYL12B, CYFIP1, HRAS, PPP1CB, CRKL, IQGAP2, SSH1, BDKRB2, MAPK1, PAK4, MSN, LIMK1, BDKRB1, MYL2, VAV2, PFN4, ARHGEF4, PDGFC, ITGB8, ITGAE, BAIAP2, ITGB2, FGFR4, ITGA3, SSH3, RAC1, ARHGAP35, MYH10, ITGB6",0.0338582672609674,0.00130484168834428,FALSE
+"HCC95","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.35227,-1.28,0.153,16573,0.49,"ATG4C, PRKAA2, ATG4A, ULK3, GABARAP, ATG7, ATG4B, PIK3C3, PIK3R4, ATG3",0.815308569182401,0.309803919971486,FALSE
+"HCC95","Input","KEGG_RENAL_CELL_CARCINOMA",0.22785,0.753,0.81,4107,0.975,"PAK2, GRB2, PIK3CA, PIK3R2, PAK6, PAK1, BRAF, MET, SLC2A1, PIK3CB, KRAS, PDGFB, HRAS, CRKL, ARNT2, TGFB2, EGLN3, MAPK1, PAK4, AKT2, ELOC",0.0915149811213502,0.0109953843014632,FALSE
+"HCC95","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.34171,1.12,0.275,2098,0.716,"CMA1, NLN, LNPEP",0.560667306169737,0.145086977692144,FALSE
+"HCC95","Input","KEGG_RETINOL_METABOLISM",0.42286,1.39,0.0886,197,0.485,"ADH7, RDH16, CYP26A1",1.05256627811295,0.314258261397736,FALSE
+"HCC95","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.40067,-1.49,0.0615,14086,0.356,"FLAD1, ACP4, PHPT1, ACP5, ACP2, ACP1",1.21112488422458,0.448550002027125,FALSE
+"HCC95","Input","KEGG_RIBOSOME",0.40256,1.33,0.125,4872,0.511,"RPL35A, RPS2, RPL12, RPLP1, RPL38, RPS17, RPL37, RPL13, RPL18A, RPS10, RPL23A, RPL27, RPL26L1, RPL22, RPS21, RPS16, RPL31, RPL22L1, RSL24D1, RPL26, RPL23, RPS18, RPL4, RPL8, RPL17, RPL19, RPS27A, RPL21, RPL7A, RPL10A, RPL3L, RPL35, FAU, RPS24, RPS23, UBA52, RPLP0, RPS3",0.903089986991944,0.291579099865287,FALSE
+"HCC95","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21245,0.69,0.898,4347,1,"TRAF6, IKBKB, MAPK13, MAPK9, MAPK10, NLRX1, MAPK12, NFKBIB, TKFC, MAVS, MAP3K7, ATG5, MAPK8, TRADD, MAPK14, MAPK11",0.0467236633326956,0,FALSE
+"HCC95","Input","KEGG_RNA_DEGRADATION",0.31295,1.04,0.376,3669,0.769,"LSM1, LSM4, LSM2, CNOT6, CNOT1, EXOSC8, EDC3, TENT4A, EXOSC2, EXOSC1, CNOT8, WDR61, HSPA9, XRN2, DCP2, LSM6, CNOT9",0.424812155072339,0.114073660198569,FALSE
+"HCC95","Input","KEGG_RNA_POLYMERASE",0.41478,1.36,0.103,5730,0.481,"POLR2H, POLR2J, POLR1D, POLR2G, POLR3G, POLR1B, POLR2D, POLR3F, POLR2J2, POLR1C, POLR2I, POLR2C, POLR3GL, POLR2F",0.987162775294828,0.317854923626168,FALSE
+"HCC95","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.38287,1.27,0.156,1510,0.553,"BUD23, METTL2B, MAT2B, AHCY",0.806875401645538,0.257274868695302,FALSE
+"HCC95","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.33346,1.09,0.316,5488,0.708,"TRAF6, LAMA1, COL4A6, IKBKB, BCL2, SKP2, PIK3CA, RXRA, PIK3R2, LAMC2, ITGA2, MYC, LAMB3, RB1, ITGA6, NOS2, ITGA2B, PIK3CB, TRAF4, LAMA3, LAMA5, AKT2, COL4A1, PTGS2, PTEN, CDKN1B, TRAF3, CCND1, PIAS2, ITGA3, COL4A4, ITGAV, IKBKG, COL4A2, E2F2",0.500312917381596,0.149966742310231,FALSE
+"HCC95","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.22491,-0.807,0.726,15588,1,"SNAP29, SNAP25, VTI1B, STX1A, BET1L, STX11, STX7, STX2, STX4, STX1B, VAMP5, SEC22B, STX12",0.139063379299906,0,FALSE
+"HCC95","Input","KEGG_SPHINGOLIPID_METABOLISM",0.2859,0.948,0.512,3379,0.863,"SPTLC1, UGT8, GLA, KDSR, PLPP1, ACER3, PLPP2, SMPD4, ASAH2",0.290730039024169,0.0639892042847904,FALSE
+"HCC95","Input","KEGG_SPLICEOSOME",0.36969,1.23,0.175,4681,0.575,"THOC3, NCBP2, DHX8, PPIL1, WBP11, LSM4, LSM2, TRA2B, SNRPE, NCBP1, HSPA1B, U2SURP, ZMAT2, CHERP, EFTUD2, DHX16, PRPF19, SF3B6, THOC1, SNRPC, SNRPB, ALYREF, EIF4A3, SART1, MAGOHB, DDX46, SRSF2, CDC5L, SNRPG, USP39, CRNKL1, AQR, CTNNBL1, SRSF8, TXNL4A, SNRNP200, PRPF4, DDX42, HNRNPA3, LSM6, PRPF6, PHF5A, HNRNPK, SRSF3, SNRPA, SRSF1, SNRNP40, HNRNPM, SNU13, SNRPD1, SRSF7, BUD31, SNRPF, HSPA2, SLU7",0.756961951313706,0.24033215531037,FALSE
+"HCC95","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.17776,-0.657,0.974,14597,0.985,"HK3, GBE1, PYGM, TREH, UGT2B7, GYS1, HK2, PGM2L1, PGM1, AMY2B",0.0114410431213845,0.00656376950238827,FALSE
+"HCC95","Input","KEGG_STEROID_BIOSYNTHESIS",0.59816,1.97,0.0095,4575,0.444,"CYP51A1, FDFT1, DHCR7, LIPA, LSS, SQLE, HSD17B7, NSDHL, TM7SF2, DHCR24, SC5D, CEL",2.02227639471115,0.35261702988538,FALSE
+"HCC95","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.45133,1.46,0.0729,1244,0.504,"AKR1C2, AKR1C1, SRD5A1, AKR1C3, HSD17B8, CYP1B1, UGT2B17",1.13727247168203,0.297569463554475,FALSE
+"HCC95","Input","KEGG_SULFUR_METABOLISM",-0.36818,-1.34,0.132,16790,0.504,"SULT2B1, CHST11, PAPSS2",0.87942606879415,0.297569463554475,FALSE
+"HCC95","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.22706,-0.806,0.71,11300,0.985,"CD80, C6, C9, ACTN2, C2, IL10, FCGR2B, FCGR2C, C7, SSB, C3, CTSG, TNF, GRIN2B, FCGR1A, ELANE, FCGR2A, TRIM21, C4A, C8G, C4B",0.148741651280925,0.00656376950238827,FALSE
+"HCC95","Input","KEGG_TASTE_TRANSDUCTION",-0.14525,-0.528,0.996,13138,0.996,"TAS2R1, SCNN1G, TAS2R9, TAS2R40, ASIC2, SCNN1B, PDE1A, TAS2R43, PLCB2, TAS1R3, ADCY4, KCNB1, TAS2R10, CACNA1A, GNG13, PRKACB, GNB1, ADCY6",0.00174066157630127,0.00174066157630127,FALSE
+"HCC95","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.27527,-1.01,0.379,13917,0.76,"ADO, CDO1, GGT5, CSAD",0.421360790031928,0.119186407719209,FALSE
+"HCC95","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.50713,1.67,0.0358,4441,0.444,"HMGCS1, HMGCR, ACAT2, MVK, IDI1",1.44611697335613,0.35261702988538,FALSE
+"HCC95","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.18184,-0.672,0.919,16691,1,"RHOA, ZFYVE9, ROCK1, NOG, INHBA, RBX1, ZFYVE16, ACVR2A, TGFB3, CDKN2B, PPP2R1A, ROCK2, THBS3, E2F5",0.0366844886138887,0,FALSE
+"HCC95","Input","KEGG_THYROID_CANCER",-0.27302,-1.03,0.363,17381,0.745,"TFG, PAX8, TCF7, PPARG, TCF7L2, TPR",0.440093374963888,0.127843727251707,FALSE
+"HCC95","Input","KEGG_TIGHT_JUNCTION",0.28847,0.943,0.514,4552,0.845,"CLDN8, CLDN11, PPP2R2C, PRKCI, YES1, PPP2CA, EPB41L1, YBX3, JAM3, EXOC4, PRKCH, VAPA, GNAI1, CLDN4, CLDN7, CSNK2A2, MYH14, PRKCQ, CRB3, EXOC3, CLDN1, AMOTL1, F11R, KRAS, MYL12B, TJAP1, HRAS, PATJ, CSNK2A1, LLGL2, TJP1, PPP2R1B, SRC, AKT2, PRKCZ, CLDN16, MYL2, PTEN",0.289036881004724,0.0731432910503077,FALSE
+"HCC95","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.20404,0.677,0.912,4347,0.998,"TRAF6, IKBKB, PIK3CA, IRF5, PIK3R2, MAPK13, MAPK9, SPP1, MAPK10, MAPK12, MAP2K6, IL1B, TLR6, PIK3CB, MAP3K7, FOS, CD40, MAPK1, MAPK8, AKT2, CD86, MAPK14, MAPK11",0.0400051616715838,0.000869458712628891,FALSE
+"HCC95","Input","KEGG_TRYPTOPHAN_METABOLISM",0.32699,1.08,0.317,1664,0.722,"CAT, EHHADH, CYP1B1, ALDH3A2, AFMID, KYNU",0.498940737782249,0.141462802430361,FALSE
+"HCC95","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.3788,1.23,0.18,4419,0.575,"IKBKB, MAFA, PIK3CA, PIK3R2, IRS1, MAPK9, SOCS1, MAPK10, SLC2A4, PIK3CB, CACNA1B, MAPK1, MAPK8, GCK, CACNA1D, HK1, PRKCZ, PKM",0.744727494896694,0.24033215531037,FALSE
+"HCC95","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.28898,0.945,0.505,4858,0.86,"IL1A, IL1B, GAD1, CD86, IL12A",0.296708621881339,0.0655015487564323,FALSE
+"HCC95","Input","KEGG_TYROSINE_METABOLISM",0.48802,1.6,0.0414,2780,0.455,"ADH7, ALDH3A1, BUD23, AOC2, GOT2, METTL2B, AOC3, ADH5, GOT1",1.3829996588791,0.341988603342888,FALSE
+"HCC95","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.29421,0.982,0.441,4493,0.805,"DLG1, PAK2, PPP3R2, IKBKB, PTPN6, GRB2, PIK3CA, PIK3R2, MAPK13, PAK6, NCK1, MAPK9, NFATC1, PAK1, MALT1, MAPK12, NFKBIB, LCK, PRKCQ, CBLC, PIK3CB, MAP3K7, CD8A, KRAS, FOS, HRAS, NCK2, MAPK1, PAK4, AKT2, NFATC3, MAPK14, MAPK11, CHP1, VAV2",0.355561410532161,0.0942041196321315,FALSE
+"HCC95","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.27263,0.903,0.59,3547,0.868,"TRAF6, UBA2, KLHL13, ANAPC1, FBXW11, FBXO2, UBE3C, UBE2H, HERC2, SKP2, UBE2S, UBE2D2, ANAPC11, UBE2B, PRPF19, TRIM37, BRCA1, SOCS1, CDC23, CUL1, UBE2O, KEAP1, UBE3A, ITCH, CBLC, UBR5, CDC26, RNF7, PML, FBXO4, UBE2Z, FANCL, ERCC8",0.229147988357856,0.0614802748235081,FALSE
+"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.44179,-1.66,0.0391,16289,0.434,"LARS2, PDHB, PDHA1",1.40782324260413,0.362510270487489,FALSE
+"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.31015,1.03,0.378,3596,0.773,"HMGCS1, EHHADH, AUH, MCCC1, ALDH3A2, PCCB, MCCC2, HADHA, ACAT2, BCAT1, IVD, OXCT1, ALDH2, HADHB, BCAT2",0.422508200162775,0.111820506081675,FALSE
+"HCC95","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.20647,0.679,0.907,2730,1,"CALML3, ADCY3, ADRA1A, GNA13, PLA2G4B, PLCB1, ADORA2B, ADCY1, PRKCH, PRKACA, ITPR3, PLA2G4A, PLA2G12A, KCNMB3, BRAF, PRKCQ",0.0423927129399047,0,FALSE
+"HCC95","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.29995,-1.09,0.259,16613,0.673,"PRKACB, RAB11B, RAB5B, STX4, ADCY6, CREB3, CREB3L1, DCTN6, DYNC1I2, DYNC1LI1, RAB5A",0.586700235918748,0.171984935776023,FALSE
+"HCC95","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.25659,0.852,0.664,4481,0.901,"RAC3, HSPB1, PPP3R2, BAD, PIK3CA, PIK3R2, PLA2G4B, MAPK13, NFATC1, PLA2G4A, PLA2G12A, MAPK12, PIK3CB, KRAS, HRAS, MAPK1, SRC, AKT2, NFATC3, MAPK14, PTGS2, MAPK11, CHP1",0.177831920631982,0.045275209020937,FALSE
+"HCC95","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25168,-0.922,0.529,17767,0.933,"ACTB, PRKCA, KDELR1, ATP6V0B, SEC61A2, ATP6V1D, ATP6V1A, SEC61A1, ATP6V0D1",0.276544327964814,0.0301183562535,FALSE
+"HCC95","Input","KEGG_VIRAL_MYOCARDITIS",0.18653,0.629,0.957,924,0.991,"EIF4G1, RAC3, CAV1",0.0190880622231565,0.00392634551472468,FALSE
+"HCC95","Input","KEGG_WNT_SIGNALING_PATHWAY",0.39701,1.29,0.133,2533,0.55,"WNT3A, SENP2, TBL1XR1, FZD1, RAC3, WNT5A, WNT8B, SFRP5, FZD10, DVL3, WNT10A, PPP3R2, WNT7B, NLK, PRICKLE1, PPP2CA, WNT11, FBXW11, WNT10B, PPP2R5D, FZD9, PLCB1, WNT9A, AXIN1, WNT7A, VANGL1, WNT16, MAPK9, PRKACA, MYC, NFATC1, WNT4, MAPK10, CSNK1A1, LEF1, CCND2, CCND3, CSNK2A2, CUL1",0.876148359032914,0.259637310505756,FALSE
+"H1975","Input","KEGG_ABC_TRANSPORTERS",0.22788,0.708,0.877,2824,0.957,"ABCA1, ABCB8, ABCG2, ABCB9, ABCB7, ABCA3, ABCA7",0.0570004066339595,0.0190880622231565,FALSE
+"H1975","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.27617,0.872,0.638,4088,0.887,"RPS6KB2, MAP2K2, CCNA1, MYC, ARAF, PPARD, PIM2, PIK3R2, CHUK, IKBKG, PIK3CA, RARA, STAT5B, MAPK1, PIK3CB",0.195179321278838,0.0520763801682736,FALSE
+"H1975","Input","KEGG_ADHERENS_JUNCTION",0.2968,0.929,0.565,6665,0.86,"SNAI1, RAC2, FER, ACTN1, RAC1, ACTB, INSR, MET, SORBS1, CDH1, PTPN1, WASL, MAPK1, RHOA, SNAI2, VCL, EGFR, IQGAP1, CSNK2A1, SMAD4, EP300, SMAD3, TJP1, PTPN6, PTPRF, ACTG1, PARD3, TGFBR1, TGFBR2, NECTIN4, ERBB2, TCF7, NECTIN1, BAIAP2",0.247951552180562,0.0655015487564323,FALSE
+"H1975","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.346,-1.3,0.162,17878,1,"MAPK10, PRKCQ, ADIPOR2, PRKAG1, PPARGC1A, JAK2, AKT3, PCK2, PRKAA2, NFKBIB, ADIPOR1, NFKBIE, PRKAB1, AKT2",0.790484985457369,0,FALSE
+"H1975","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.29001,0.903,0.588,3808,0.859,"ASL, GFPT2, GLS, GLUD1, GOT2, ASS1, CPS1, ADSL",0.230622673923862,0.0660068361687577,FALSE
+"H1975","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.1833,0.577,0.978,4088,0.975,"ATP1A2, INSR, PRKCA, SFN, PIK3R2, FXYD4, IRS1, PIK3CA, MAPK1, PIK3CB",0.00966114521239857,0.0109953843014632,FALSE
+"H1975","Input","KEGG_ALLOGRAFT_REJECTION",0.35646,1.11,0.286,2347,0.682,"IL12B, CD40",0.543633966870957,0.166215625343521,FALSE
+"H1975","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.22711,-0.869,0.574,12217,1,"PLA2G4E, PLA2G12B, PLA2G2F, PLA2G5, PLA2G2A, ACOX3, PLA2G1B, PLA2G3, PLA2G10, PLA2G4A, PLA2G4B",0.241088107602027,0,FALSE
+"H1975","Input","KEGG_ALZHEIMERS_DISEASE",0.28996,0.906,0.597,5115,0.879,"NDUFV1, COX8C, GRIN2A, UQCR11, NDUFS8, CALM1, UQCR10, NDUFA7, ATP5F1B, GRIN1, NDUFB7, COX6B2, BACE1, GRIN2D, NDUFA6, SDHA, FADD, APH1A, NDUFS2, CASP8, NDUFB2, NDUFS7, NDUFA3, SDHC, UQCRC1, ITPR1, ATP5F1D, PSEN1, NDUFB6, NDUFA8, EIF2AK3, CAPN2, HSD17B10, PPP3CA, GSK3B, NAE1, CYCS, MAPK1, COX7B, NDUFA5, APBB1, NDUFV3, ATP2A3, CDK5, NDUFB10, IDE, TNFRSF1A, ITPR3, NDUFA4, PSEN2, NDUFS6, ATF6",0.224025668870631,0.0560111249262281,FALSE
+"H1975","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.56287,1.76,0.0171,2635,0.512,"FARS2, FARSA, TARS2, DARS2, LARS2, IARS2, CARS2, EARS2",1.76700388960785,0.290730039024169,FALSE
+"H1975","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.43562,1.34,0.11,5221,0.517,"GCK, GFPT2, GNPDA1, GMPPA, CYB5R3, HK2, RENBP, GMPPB, NANP, GALK1, PGM2, AMDHD2, NANS, UAP1, UGDH, HEXB, HK1, NAGK, PMM1, GNPNAT1, UGP2",0.958607314841775,0.286509456906058,FALSE
+"H1975","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28289,0.872,0.651,3910,0.887,"CCS, GRIN2A, GRIN1, TP53, GRIN2D, RAC1, TOMM40L, GPX1, MAPK12, CAT, PPP3CA, CYCS, MAPK13",0.186419011431808,0.0520763801682736,FALSE
+"H1975","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.33851,1.04,0.356,5574,0.78,"HSP90AA1, LGMN, CIITA, KLRC1, IFI30, CD74, HSPA1A, CTSL, HSPA2, NFYA, HSPA1B, HSPA8, KIR2DL1, CTSS, CTSB, TAP2, PSME1, CALR, CREB1, RFXANK, RFX5, PSME2, PSME3",0.448550002027125,0.10790539730952,FALSE
+"H1975","Input","KEGG_APOPTOSIS",0.24908,0.782,0.747,4699,0.955,"PRKAR1B, IL1RAP, TP53, ENDOD1, AIFM1, FADD, IRAK1, TRADD, CASP8, CASP10, IL1R1, IRAK4, PRKACA, PIK3R2, XIAP, CHUK, IKBKG, PRKAR2A, PIK3CA, CAPN2, PPP3CA, MYD88, CYCS, PIK3CB, RIPK1, DFFA, TNFRSF1A",0.126679398184601,0.0199966284162537,FALSE
+"H1975","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.32602,1.01,0.422,2668,0.797,"CYP2C9, CYP2E1, GPX4, CYP2C8, PLA2G2C, PTGES2, PTGES, GPX3, GPX1",0.374687549038326,0.0985416786038876,FALSE
+"H1975","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.4526,1.41,0.0762,3980,0.487,"NOS3, ASL, ALDH9A1, SAT2, SMS, GLS, OAT, GLUD1, MAOB, ALDH1B1, GOT2, P4HA1, P4HA3, ASS1, SRM, NAGS, CPS1, MAOA",1.1180450286604,0.312471038785366,FALSE
+"H1975","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.25699,-0.993,0.437,15938,1,"CACNG7, ITGA7, SGCD, ITGA9, ACTN2, CACNA2D3, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, ITGA4, ATP2A2, SLC8A1, DMD, LEF1, PKP2, CACNA2D1, ITGB8, CDH2",0.359518563029578,0,FALSE
+"H1975","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.31672,0.984,0.468,4264,0.816,"ALDH9A1, ALDH1B1, UGDH",0.329754146925876,0.0883098412461389,FALSE
+"H1975","Input","KEGG_ASTHMA",0.51364,1.61,0.0256,16,0.345,"RNASE3",1.59176003468815,0.462180904926726,FALSE
+"H1975","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.39029,-1.46,0.0807,10027,1,"IFNA4, TSHR, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, FASLG, TSHB, CD80, IFNA13, CTLA4, IL10, IFNA21, PRF1, TPO, IFNA8, CGA, IFNA1, IFNA5, CD86, GZMB, FAS, TG, IL5",1.09312646527793,0,FALSE
+"H1975","Input","KEGG_AXON_GUIDANCE",0.30621,0.948,0.52,5502,0.851,"SEMA5B, LIMK1, PAK6, NGEF, RAC2, ABLIM3, NTN1, EPHB4, PAK2, SEMA4B, EFNA4, RASA1, RAC1, EFNA1, SEMA7A, PAK1, SEMA3A, SEMA3B, MET, GNAI2, ABLIM1, CFL2, ABLIM2, UNC5A, PLXNB3, PPP3CA, GSK3B, NFATC3, NRP1, EPHA1, MAPK1, SRGAP1, RHOA, EPHB2, SEMA6C, EPHA6, CDK5, ROCK2, ABL1, EFNB2, SEMA3C, SEMA6B, RHOD, SEMA3E, ITGB1, ROBO3, SRGAP2, GNAI1, SEMA4C, EFNA5",0.283996656365201,0.0700704399154121,FALSE
+"H1975","Input","KEGG_BASAL_CELL_CARCINOMA",-0.21862,-0.823,0.715,15646,1,"WNT2B, FZD5, GLI1, WNT7A, DVL3, WNT8B, FZD7, WNT6, HHIP, WNT10A, AXIN2, WNT4, WNT11, WNT5A, FZD8, FZD1, LEF1, WNT5B, SMO",0.145693958198919,0,FALSE
+"H1975","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.26325,-0.991,0.413,17864,1,"TAF13, GTF2F2, GTF2B, STON1, GTF2A2, GTF2H2",0.384049948343599,0,FALSE
+"H1975","Input","KEGG_BASE_EXCISION_REPAIR",0.37222,1.16,0.239,4598,0.602,"POLD4, POLD2, NTHL1, SMUG1, APEX2, APEX1, OGG1, MBD4, PARP2, POLE3, POLE2, PCNA, PARP3, POLE4",0.621602099051862,0.220403508742175,FALSE
+"H1975","Input","KEGG_BETA_ALANINE_METABOLISM",0.54922,1.69,0.0162,4373,0.269,"AOC2, ALDH9A1, SMS, AOC3, ECHS1, ALDH1B1, HADHA, SRM, EHHADH",1.79048498545737,0.570247719997592,FALSE
+"H1975","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.34961,1.09,0.327,4115,0.692,"ELOVL6, HACD1, ACAA1, HADHA, ACOT4, ACOT1, SCD",0.485452247339714,0.159893905543242,FALSE
+"H1975","Input","KEGG_BLADDER_CANCER",-0.26046,-0.93,0.559,17226,1,"FGFR3, EGF, E2F2, HRAS, CXCL8, MMP2, MDM2, VEGFC, KRAS, RB1",0.252588192113577,0,FALSE
+"H1975","Input","KEGG_BUTANOATE_METABOLISM",0.36894,1.17,0.215,3682,0.599,"ALDH9A1, ECHS1, PDHA1, ACAT1, ALDH1B1, HADHA, L2HGDH, OXCT1, PDHB, ACSM3",0.667561540084395,0.222573177610689,FALSE
+"H1975","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.2891,0.904,0.602,4395,0.865,"CD79A, CD19, VAV1, MAP2K2, RAC2, LILRB3, CARD11, RAC1, LYN, PIK3R2, IFITM1, CHUK, IKBKG, PIK3CA, PPP3CA, GSK3B, NFATC3, MAPK1, PIK3CB, VAV2, PLCG2",0.220403508742175,0.0629838925351858,FALSE
+"H1975","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.27157,0.848,0.681,2913,0.888,"NOS3, P2RX6, GRIN2A, MYLK2, PTGER1, P2RX5, GNA15, CALM1, GRIN1, CACNA1B, CACNA1A, ADCY7, GNA11, PHKA1, ADORA2B, EDNRA, ADORA2A, HRH1, MYLK, GRIN2D, TBXA2R, SPHK1, PRKCA, F2R, TRPC1, ITPR1, PRKACA, SLC25A5, ATP2B1, ATP2B4",0.166852888087215,0.051587034221399,FALSE
+"H1975","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.24677,-0.857,0.597,16714,1,"CACNA2D3, CACNA2D4, ATP1B1, CACNB4, UQCRFS1, CACNA1C, RYR2, CACNA1D, SLC9A1, TPM2, UQCRHL, ATP2A2, TNNC1, SLC8A1, COX7A2, ATP1A3, CYC1, COX6A1, CACNA2D1, COX6B1",0.224025668870631,0,FALSE
+"H1975","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.19139,-0.689,0.891,16314,0.943,"NRXN2, CD6, ITGA9, NLGN4X, SDC2, CNTN1, CD4, ESAM, JAM2, CNTNAP2, CDH4, ITGAM, NRXN3, NCAM2, NEGR1, MPZL1, NLGN1, NCAM1, ITGA4, NFASC, NECTIN2, NRCAM, JAM3, CLDN1, ITGB8, CDH2",0.0501222959631252,0.0254883072626717,FALSE
+"H1975","Input","KEGG_CELL_CYCLE",0.37701,1.18,0.221,5773,0.609,"SMC1B, YWHAH, CCNA1, ATR, DBF4, MYC, CDC25B, FZR1, CDK7, TP53, CCNB1, CUL1, PLK1, YWHAQ, CDKN1C, RBL1, BUB3, GADD45B, SFN, CDC20, ESPL1, SMC1A, MCM7, TFDP2, STAG2, BUB1, YWHAE, CCNH, TGFB2, CHEK1, GSK3B, ORC5, CDC45, PCNA, MCM2, E2F4, CDKN2B, TGFB3, MCM6, CDC27, ORC2, ABL1, CDC25C, SMAD4, PKMYT1, ANAPC2, MCM5, SMC3, CHEK2, EP300, ORC6, SMAD3, CDK4, ANAPC1, CDKN2A, SKP1, TTK, E2F1, CDC6, YWHAG",0.655607726314889,0.215382707367125,FALSE
+"H1975","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.20737,-0.805,0.731,16907,1,"ADCY5, GNG5, XCL1, NFKBIA, CXCL1, SHC2, CSK, CXCL3, ELMO1, GNG2, CXCR4, PIK3CD, HRAS, CXCL8, PRKACB, CCL20, JAK2, ADCY1, PTK2, GNB1, AKT3, PLCB4, PIK3R1, KRAS, ADCY6, GNG4, NFKBIB, PLCB1, CXCL16, AKT2, GSK3A",0.13608262304214,0,FALSE
+"H1975","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.20631,0.646,0.93,5841,0.976,"MAP2K2, MYC, ARAF, TP53, MECOM, CRK, SHC3, PIK3R2, CHUK, IKBKG, TGFB2, PIK3CA, BCR, STAT5B, MAPK1, CTBP2, PIK3CB, TGFB3, RUNX1, ABL1, SMAD4, BRAF, CBLC, SMAD3, AKT1, CDK4, CDKN2A, E2F1, TGFBR1",0.0315170514460649,0.0105501823333082,FALSE
+"H1975","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.43941,-1.67,0.0333,16670,0.799,"PER2, CRY2, CSNK1D, CRY1",1.47755576649368,0.0974532206860086,FALSE
+"H1975","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.47633,1.51,0.0573,3635,0.489,"PC, IDH3G, IDH3B, MDH2, DLD, PDHA1, SDHA, SDHC, OGDH, CS, PDHB, ACO2",1.24184537803261,0.31069114087638,FALSE
+"H1975","Input","KEGG_COLORECTAL_CANCER",0.24649,0.775,0.779,5841,0.951,"RAC2, MYC, ARAF, TP53, RAC1, MLH1, PIK3R2, MSH6, APPL1, APC, TGFB2, PIK3CA, GSK3B, CYCS, MAPK1, RHOA, PIK3CB, TGFB3, SMAD4, RALGDS, BRAF, SMAD3, AKT1, AXIN1, FOS, TGFBR1",0.108462542327436,0.0218194830625861,FALSE
+"H1975","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.33882,1.06,0.373,2604,0.736,"C4B, C4A, SERPINA5, PROS1, SERPINA1, CFB, F8, C3, SERPINE1, PLAU, F2R, TFPI",0.428291168191312,0.133122185662501,FALSE
+"H1975","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.41449,1.3,0.131,3574,0.501,"LDHC, LDHA, SMS, DNMT1, ADI1, AHCY, LDHAL6B, GOT2, MTR, SRM",0.882728704344236,0.300162274132754,FALSE
+"H1975","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20255,0.628,0.953,3472,0.982,"CRLF2, CSF1R, IL12B, EPOR, TNFRSF18, TNFRSF11A, CLCF1, TNFRSF6B, TNFSF9, AMH, IL7R, BMP2, IL11, IL13RA1, IL1RAP, CCL26, IL24, TNFSF12, CD70, OSMR, IL4R, IL15RA, CD40, IL1R1, CX3CL1, CCL28, MET, ACVR1B, IL6R, LIFR, CSF1, KITLG, CTF1, CCR4, TGFB2",0.0209070993616736,0.00788851221305034,FALSE
+"H1975","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.27408,0.866,0.645,3898,0.891,"AIM2, MAVS, ADAR, POLR3H, POLR3G, POLR3A, DDX58, POLR3GL, CHUK, IKBKG, POLR1C",0.190440285364732,0.0501222959631252,FALSE
+"H1975","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22818,-0.85,0.605,14422,1,"IGF1, CACNG1, ADRB1, ACTC1, ADCY2, ITGA1, TGFB1, TNNT2, SGCG, CACNA2D2, ADCY4, TNF, CACNG7, ITGA7, SGCD, ITGA9, CACNA2D3, ADCY5, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, TPM2, ITGA4, ATP2A2, PRKACB, TNNC1, SLC8A1, ADCY1, DMD, CACNA2D1, ADCY6, ITGB8",0.218244625347531,0,FALSE
+"H1975","Input","KEGG_DNA_REPLICATION",0.48318,1.49,0.0642,5008,0.424,"POLD4, POLD2, RPA3, RNASEH2A, RNASEH1, PRIM1, SSBP1, RFC2, MCM7, POLE3, RNASEH2C, POLE2, RPA1, PCNA, MCM2, MCM6, POLE4, MCM5",1.19246497193115,0.372634143407267,FALSE
+"H1975","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.19145,-0.687,0.802,12053,0.924,"SOS2, MAP2K1, ETV6, NOTCH4, PIWIL4, PIWIL3, PIWIL2, PIWIL1, ETV7, NOTCH3, CPEB1, FMN2, KRAS",0.0958256317158365,0.0343280287798933,FALSE
+"H1975","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.40864,1.26,0.173,4256,0.512,"CYP2C9, GSTT2, CYP2E1, ALDH3B1, CYP2C8, GSTZ1, GSTO2, ALDH3B2, GSTK1, MAOB, AOX1, MGST1, MGST3, MAOA, FMO4, GSTP1",0.761953896871205,0.290730039024169,FALSE
+"H1975","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.42535,1.32,0.124,3217,0.514,"IMPDH2, CDA, HPRT1, UPP1, IMPDH1, UMPS, TYMP, UCK2, ITPA, TK2",0.906578314837765,0.289036881004724,FALSE
+"H1975","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.20917,-0.778,0.756,15893,0.992,"CD36, ITGA7, COL11A1, COL5A3, THBS2, HSPG2, ITGA9, SDC2, VWF, LAMA5, COL4A4, COL3A1, LAMA2, LAMC3, LAMA1, SV2A, COL5A2, ITGA4, LAMA4, ITGB8, COL4A1, COL4A2, LAMB1",0.121478204498793,0.00348832784582135,FALSE
+"H1975","Input","KEGG_ENDOCYTOSIS",0.24636,0.771,0.817,5364,0.95,"CSF1R, CHMP2A, RABEP1, EPN1, SMURF1, CHMP3, SH3KBP1, RAB31, LDLR, DNM2, GRK5, PIP5K1C, RAB11B, GRK3, HSPA1A, PLD2, F2R, RBSN, HSPA2, MET, STAM, SH3GL1, AP2M1, EHD2, GRK2, IQSEC1, PDCD6IP, ITCH, AGAP1, HSPA1B, CHMP4C, AP2B1, HSPA8, EPN3, MVB12A, ARF6, ARFGAP3, PSD4, CLTCL1, VPS45, ACAP1, ARRB1, CLTC, RNF41, EGFR, EEA1, ADRB2, STAM2, CHMP2B, CBLC, RAB11FIP2, SNF8, RAB11FIP1, ARFGAP1",0.0877779434675845,0.0222763947111523,FALSE
+"H1975","Input","KEGG_ENDOMETRIAL_CANCER",0.24916,0.777,0.786,4970,0.956,"MAP2K2, MYC, ARAF, PTEN, TP53, MLH1, ELK1, PIK3R2, APC, CDH1, PIK3CA, GSK3B, FOXO3, MAPK1, PIK3CB, EGFR, PDPK1, BRAF",0.104577453960592,0.0195421077238999,FALSE
+"H1975","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23816,0.76,0.814,4626,0.961,"ATP6V0D2, NOD1, ATP6V0D1, RAC1, MAP2K4, LYN, PAK1, ATP6V1D, MET, ATP6V1F, ATP6V1E2, MAPK12, CHUK, IKBKG, MAPK13, TCIRG1, F11R, ATP6V0E2, PLCG2, EGFR",0.0893755951107988,0.0172766123314547,FALSE
+"H1975","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.24386,0.755,0.818,5113,0.961,"RPS6KB2, MAP2K2, PAK6, MYC, ARAF, PAK2, MAP2K4, CRK, ABL2, PRKCA, ELK1, PAK1, SHC3, MAP2K7, PIK3R2, PIK3CA, GSK3B, STAT5B, MAPK1, PIK3CB, NRG1, PLCG2, EGFR, ABL1, BRAF, CBLC, CAMK2D",0.087246696328677,0.0172766123314547,FALSE
+"H1975","Input","KEGG_ETHER_LIPID_METABOLISM",0.29926,0.931,0.543,4032,0.865,"LPCAT1, PLA2G2C, PAFAH1B1, PLPP2, PLD2, AGPS, PLA2G12A, LPCAT2",0.265200170411153,0.0629838925351858,FALSE
+"H1975","Input","KEGG_FATTY_ACID_METABOLISM",0.41741,1.3,0.137,4656,0.501,"GCDH, ALDH9A1, ACSL4, ACAA1, ECHS1, ACSL5, ACAT1, ALDH1B1, HADHA, ACADVL, CPT1C, ACADSB, EHHADH, ACAA2",0.863279432843593,0.300162274132754,FALSE
+"H1975","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.2102,-0.794,0.771,16759,0.983,"MAPK11, INPP5D, PLA2G10, IL13, PLCG1, PLA2G4A, MAPK10, PIK3CD, HRAS, PLA2G4B, AKT3, PIK3R1, GAB2, KRAS, MAP2K6, AKT2",0.112945621949043,0.00744648216786438,FALSE
+"H1975","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.27975,0.862,0.663,4395,0.883,"RPS6KB2, VAV1, LIMK1, RAC2, PLA2G4D, ARPC1A, DNM2, PIP5K1C, RAC1, CRK, LYN, ARPC1B, MYO10, SPHK1, PRKCA, PAK1, PLPP2, PLD2, PIK3R2, CFL2, PIK3CA, WASL, ARF6, MAPK1, PRKCD, PIK3CB, VAV2, PLCG2",0.178486471595227,0.0540392964224314,FALSE
+"H1975","Input","KEGG_FOCAL_ADHESION",0.22691,0.696,0.883,5199,0.956,"PPP1CA, VAV1, MYLK2, THBS3, PAK6, RAC2, COL5A1, PTEN, ARHGAP5, ITGA5, ITGA2B, PAK2, LAMB3, PIP5K1C, ITGB3, ACTN1, TNC, MYLK, RAC1, ACTB, CRK, CAV2, PRKCA, FLNA, ELK1, ZYX, PAK1, SHC3, CAV1, DIAPH1, MYL9, MET, VTN, MYL7, PIK3R2, XIAP, LAMA3, PIK3CA, COL1A1, PPP1CB, CAPN2, GSK3B, MAPK1, BCAR1, ITGA3, RHOA, PIK3CB, FN1, VAV2, COL1A2, VCL, EGFR, ROCK2, LAMB2, PDPK1, FLNB, ITGA2, LAMC2, BRAF, DOCK1, LAMC1, ITGB1",0.0540392964224314,0.0195421077238999,FALSE
+"H1975","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.3703,-1.36,0.155,12122,1,"ALPI, ALPL, ALPG, QDPR, ALPP, PTS, GGH, GCH1",0.809668301829709,0,FALSE
+"H1975","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.44997,1.4,0.0899,7631,0.489,"ALDOA, FBP1, PFKFB4, ALDOC, GMPPA, AKR1B1, HK2, GMPPB, PFKP, HK1, PFKFB3, PMM1, SORD, MTMR2, PFKFB1, MPI, PFKFB2, PFKL, PFKM, PMM2, FBP2, GMDS, MTMR1",1.04624030826677,0.31069114087638,FALSE
+"H1975","Input","KEGG_GALACTOSE_METABOLISM",0.4783,1.48,0.0759,6884,0.423,"GCK, AKR1B1, HK2, GALK1, PGM2, PFKP, GLA, HK1, UGP2, GAA, PGM1, B4GALT1, GALE, PFKL",1.11975822410452,0.373659632624958,FALSE
+"H1975","Input","KEGG_GAP_JUNCTION",-0.22836,-0.822,0.711,15831,1,"TUBB4A, GNAI3, DRD2, GUCY1B1, HTR2C, PDGFD, ADCY5, PDGFRA, GUCY1A2, PRKG1, PRKG2, GUCY1A1, TUBB1, EGF, CSNK1D, HRAS, PRKACB, MAP2K5, ADCY1, PLCB4, KRAS, ADCY6, LPAR1, PLCB1",0.148130399270234,0,FALSE
+"H1975","Input","KEGG_GLIOMA",-0.26745,-0.987,0.382,17036,1,"PDGFRA, CALML6, CAMK2B, SHC2, EGF, PLCG1, E2F2, PIK3CD, HRAS, AKT3, PIK3R1, MDM2, KRAS, RB1, AKT2",0.417936637088291,0,FALSE
+"H1975","Input","KEGG_GLUTATHIONE_METABOLISM",0.41165,1.28,0.144,4822,0.494,"GSTT2, GPX4, ANPEP, GSTZ1, GSTO2, SMS, GSTK1, GPX3, GPX1, RRM2, MGST1, SRM, MGST3, GSTP1, G6PD, GGCT, ODC1, GGT7, GSTM2, GSS",0.84163750790475,0.306273051076353,FALSE
+"H1975","Input","KEGG_GLYCEROLIPID_METABOLISM",0.40366,1.25,0.169,4681,0.523,"GPAT2, DGKI, LIPG, AWAT2, ALDH9A1, DGKD, AKR1B1, AGK, DGKG, ALDH1B1, PLPP2, GPAT3, MGLL, MBOAT2, GK, AGPAT4, GLA, DGKE, GPAM",0.772113295386326,0.281498311132726,FALSE
+"H1975","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33238,1.02,0.41,4681,0.791,"GPAT2, DGKI, LPCAT1, PLA2G2C, MBOAT7, CDS2, PEMT, CRLS1, DGKD, DGKG, CHKA, PLPP2, PLD2, GPAT3, CHAT, PISD, CDIPT, MBOAT2, PLA2G12A, LPCAT2, AGPAT4, PCYT1A, DGKE, GPAM",0.387216143280265,0.101823516502323,FALSE
+"H1975","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.47415,1.49,0.0546,3268,0.424,"SARDH, AOC2, SRR, AOC3, DLD, SHMT1, MAOB, GCAT, PSPH, SHMT2",1.26280735729526,0.372634143407267,FALSE
+"H1975","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.50151,1.57,0.0412,2784,0.396,"GCK, LDHC, ALDH3B1, ALDOA, PGK1, LDHA, FBP1, ALDH9A1, ALDH3B2, ALDOC, DLD, PDHA1, GALM, PGAM1, LDHAL6B, ALDH1B1, HK2",1.38510278396687,0.402304814074488,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36869,1.16,0.215,5040,0.602,"CHST15, CHPF2, CHPF, CHST3, DSE, CHST11, CHST12, UST",0.667561540084395,0.220403508742175,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.19621,-0.743,0.816,12537,1,"HS3ST1, HS2ST1, NDST4, HS3ST2, HS6ST1, NDST2, EXTL1, HS3ST5, HS6ST3, NDST3, B3GAT1, B3GAT2, XYLT1",0.0883098412461389,0,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.48123,1.49,0.0552,1059,0.424,"CHST4, CHST6, FUT8, B3GNT7",1.2580609222708,0.372634143407267,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.41649,1.29,0.139,4328,0.498,"IDS, HYAL2, HYAL3, GALNS, HS3ST3B1, HYAL1, NAGLU, HEXB",0.856985199745905,0.302770657240282,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.24119,-0.904,0.568,14944,1,"B3GALT4, ST8SIA5, ST6GALNAC5, ST6GALNAC3, HEXA, ST3GAL5",0.245651664288981,0,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.43308,1.36,0.103,6501,0.503,"FUT2, B3GALNT1, ST3GAL2, GLA, HEXB, A4GALT, NAGA, ST8SIA1, GBGT1, B3GALT5",0.987162775294828,0.298432014944073,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.23892,-0.903,0.569,15377,1,"ST3GAL4, ST3GAL3, B3GALT2, FUT9, B3GALT1, B3GNT2, B4GAT1, B4GALT4, ST3GAL6",0.244887733604929,0,FALSE
+"H1975","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.27147,0.849,0.679,6205,0.894,"PIGQ, PIGL, PIGW, DPM2, PIGX, PIGH, PIGA, PIGG, PIGM, PIGB, PIGV, PIGN, PGAP1",0.168130225719498,0.0486624812040823,FALSE
+"H1975","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.35487,1.11,0.286,4253,0.682,"MTHFD1, MDH2, CS, ACO2, HYI",0.543633966870957,0.166215625343521,FALSE
+"H1975","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.22997,-0.833,0.644,16759,1,"MAPK11, ADCY5, PLA2G10, CACNA1C, CALML6, CAMK2B, CACNA1D, PLA2G4A, MAPK10, HRAS, PRKACB, PLA2G4B, MMP2, GNRH1, ADCY1, PLCB4, KRAS, ADCY6, ATF4, PLCB1, MAP2K6",0.191114132640188,0,FALSE
+"H1975","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.26642,-1.01,0.397,14812,1,"KLRD1, CD86, GZMB, FAS, TNF, IL1A, IL1B",0.401209493236885,0,FALSE
+"H1975","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.23504,-0.885,0.616,17337,1,"HHIP, WNT10A, WNT4, WNT11, GAS1, CSNK1D, WNT5A, BMP6, BMP7, PRKACB, WNT5B, SMO",0.210419287835575,0,FALSE
+"H1975","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.31328,0.964,0.488,3553,0.85,"CSF1R, CD19, EPOR, ANPEP, IL7R, IL11, ITGA5, ITGA2B, ITGB3, IL4R, IL1R1, IL6R, CSF1, KITLG, CD44",0.311580177997289,0.0705810742857073,FALSE
+"H1975","Input","KEGG_HISTIDINE_METABOLISM",0.54462,1.71,0.0142,3072,0.334,"FTCD, ALDH3B1, ALDH9A1, ALDH3B2, HEMK1, MAOB, HNMT, METTL6, ALDH1B1, METTL2B",1.84771165561694,0.476253533188435,FALSE
+"H1975","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.53981,1.7,0.0212,3919,0.281,"POLD4, POLD2, NBN, RPA3, RAD51B, XRCC2, XRCC3, SSBP1, RAD51D, TOP3B, MRE11, TOP3A, RPA1",1.67366413907125,0.55129368009492,FALSE
+"H1975","Input","KEGG_HUNTINGTONS_DISEASE",0.37717,1.17,0.228,3032,0.599,"DNAH2, NDUFV1, CREB3L3, COX8C, DNAH3, UQCR11, NDUFS8, CREB3L1, UQCR10, HIP1, TBPL2, NDUFA7, ATP5F1B, GRIN1, NDUFB7, COX6B2, TP53, RCOR1, POLR2E, DNAH1, PPARG, DNAL1, POLR2J, IFT57, NDUFA6, SDHA, POLR2F, NDUFS2, CASP8, NDUFB2, NDUFS7, TGM2, NDUFA3, SDHC, UQCRC1, GPX1, ITPR1, ATP5F1D, SLC25A5, NDUFB6, AP2M1, NDUFA8, TFAM, POLR2H",0.642065152999546,0.222573177610689,FALSE
+"H1975","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.22257,-0.776,0.721,15780,0.968,"TNF, CACNG7, ITGA7, SGCD, ITGA9, CACNA2D3, CACNA2D4, CACNB4, CACNA1C, RYR2, LAMA2, CACNA1D, TPM2, ITGA4, ATP2A2, PRKAG1, TNNC1, SLC8A1, DMD, CACNA2D1, ITGB8, PRKAA2, PRKAB1",0.142064735280571,0.0141246426916063,FALSE
+"H1975","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.23056,0.711,0.872,5131,0.961,"PTEN, PIP5K1C, IMPA2, IPMK, PIP4K2C, INPP5J, PIP4K2A, PI4KB, PIK3CA, CDIPT, INPP5K, PIK3C2A, PIK3CB, PLCG2, PIK3C3, PLCE1, SYNJ2",0.0594835150674328,0.0172766123314547,FALSE
+"H1975","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.3059,0.962,0.489,4088,0.845,"GCK, PPP1CA, RPS6KB2, MAP2K2, PRKAR1B, CALM1, FBP1, ARAF, PYGL, PHKA1, CRK, INSR, ELK1, PRKAG2, SHC3, PPP1R3B, PRKAB2, PRKAA1, HK2, PPP1R3C, PRKACA, TRIP10, PIK3R2, SORBS1, PYGB, IRS1, PRKAR2A, MKNK2, PIK3CA, PHKB, PPP1CB, GSK3B, TSC1, PTPN1, INPP5K, MAPK1, RHEB, PIK3CB",0.31069114087638,0.0731432910503077,FALSE
+"H1975","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.20136,-0.742,0.827,14917,0.983,"TGFB1, CD86, ICOSLG, CCL27, IL5, CXCL12, TNFSF13B, TNFRSF13C, CXCR4, ITGA4",0.0824944904474534,0.00744648216786438,FALSE
+"H1975","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.21942,0.682,0.91,4091,0.965,"CRLF2, IL12B, EPOR, TYK2, CLCF1, IL7R, MYC, IL11, IL13RA1, IL24, OSMR, IL4R, IL15RA, PIAS4, STAM, PIAS2, PIAS3, PIK3R2, IL6R, LIFR, JAK3, STAT6, CTF1, PIK3CA, STAT5B, IRF9, PIK3CB, IFNGR1",0.0409586076789064,0.0154726866562074,FALSE
+"H1975","Input","KEGG_LEISHMANIA_INFECTION",0.22892,0.719,0.875,4133,0.966,"IL12B, C3, IRAK1, ELK1, ITGB2, IRAK4, MAPK12, TGFB2, TAB1, CYBA, MYD88, MAPK1, MAPK13, IFNGR1, TGFB3",0.0579919469776868,0.0150228735845067,FALSE
+"H1975","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19732,0.605,0.951,5361,0.976,"VAV1, RAC2, ARHGAP5, CLDN9, ACTN1, RAC1, ACTB, CLDN4, PRKCA, ITGB2, MYL9, MSN, MYL7, GNAI2, PIK3R2, ICAM1, MAPK12, CLDN23, CLDN7, PIK3CA, CYBA, MAPK13, BCAR1, RHOA, PIK3CB, F11R, VAV2, PLCG2, SIPA1, VCL, ROCK2, PTK2B, CLDN15, ITGB1, GNAI1, NCF2, CLDN22",0.0218194830625861,0.0105501823333082,FALSE
+"H1975","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.6488,2.02,0.00356,4373,0.436,"ALDH9A1, NAA80, ECHS1, ALDH1B1, HADHA, EHHADH",2.44855000202712,0.360513510731414,FALSE
+"H1975","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.46749,1.45,0.0795,606,0.462,"CYP2C9, CYP2E1, CYP2C8, PLA2G2C",1.09963287134353,0.335358024443874,FALSE
+"H1975","Input","KEGG_LONG_TERM_DEPRESSION",0.23549,0.722,0.837,2875,0.977,"PPP2R1A, MAP2K2, PLA2G2C, GNA12, ARAF, CACNA1A, GNA11, LYN, PRKCA, ITPR1, GNAI2",0.07727454200674,0.0101054362812269,FALSE
+"H1975","Input","KEGG_LONG_TERM_POTENTIATION",0.25539,0.802,0.764,2802,0.954,"PPP1CA, GRIN2A, MAP2K2, CALM1, RPS6KA3, GRIN1, ARAF, GRIN2D, RPS6KA2, PRKCA, ITPR1, PRKACA",0.11690664142431,0.0204516252959049,FALSE
+"H1975","Input","KEGG_LYSINE_DEGRADATION",0.29949,0.934,0.541,5620,0.867,"GCDH, ALDH9A1, AADAT, SUV39H1, ECHS1, ACAT1, PLOD2, SETMAR, ALDH1B1, HADHA, OGDH, KMT5C, EHHADH, KMT5B, SETD2, PLOD1, ASH1L, PLOD3, DLST",0.266802734893431,0.0619809025237897,FALSE
+"H1975","Input","KEGG_LYSOSOME",0.42113,1.32,0.12,4887,0.514,"AP3S1, ACP5, NPC1, ATP6V0D2, LIPA, NAGPA, AP1B1, CTNS, LGMN, GALC, ATP6V0D1, CTSA, ABCB9, AP1S1, IDS, CD68, DNASE2, AP3D1, PSAP, CTSG, SUMF1, CTSF, LAMP2, CTSD, TPP1, GALNS, CTSL, AP1M1, AP1S3, GBA, AP3B1, NPC2, AP4S1, NAPSA, HYAL1, MAN2B1, NAGLU, AGA, CTSS, CLTCL1, GLA, TCIRG1, CTSC, HEXB, CTSB, CLTC, AP1G1, NAGA, NEU1, CTSV, MCOLN1",0.920818753952375,0.289036881004724,FALSE
+"H1975","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.22854,0.718,0.863,4176,0.96,"ECSIT, MAP2K2, CACNG8, PLA2G2C, RAC2, MAPKAPK3, MAX, MYC, RPS6KA3, CDC25B, GNA12, CACNA1B, DUSP9, PPM1A, CACNA1A, PAK2, TP53, MECOM, RASA1, HSPB1, RAC1, MAP2K4, CRK, HSPA1A, MAP3K20, RPS6KA2, PRKCA, FLNA, ELK1, PAK1, IL1R1, GADD45B, MAP3K3, MAP2K7, HSPA2, PRKACA, RRAS2, DUSP10, MAP4K4, FGF1, MAPK12, MRAS, CHUK, MAPK8IP2, DUSP2, IKBKG, TGFB2, MKNK2, HSPA1B, HSPA8, PPP3CA, RPS6KA4, TAB1, FGF13, MAPK1, MAPK13, PLA2G12A, DUSP3, TGFB3, MAP3K6",0.0639892042847904,0.0177287669604316,FALSE
+"H1975","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.38632,1.21,0.196,11,0.57,"GCK",0.707743928643524,0.244125144327509,FALSE
+"H1975","Input","KEGG_MELANOGENESIS",-0.18683,-0.718,0.873,15583,0.974,"NRAS, WNT2B, EDNRB, FZD5, GNAI3, WNT7A, TYRP1, DVL3, WNT8B, FZD7, KIT, ADCY5, WNT6, CALML6, CAMK2B, WNT10A, WNT4, WNT11, WNT5A, HRAS, PRKACB, FZD8, FZD1, ADCY1, LEF1, PLCB4, WNT5B, KRAS, ADCY6, PLCB1",0.0589857562944303,0.0114410431213845,FALSE
+"H1975","Input","KEGG_MELANOMA",-0.27622,-1.04,0.362,14247,1,"PIK3R3, FGF19, FGF20, IGF1, CDKN1A, HGF, PIK3CG, FGF18, FGF9, FGF7, FGF21, NRAS, FGF14, CDK6, E2F3, PDGFD, PDGFRA, FGF17, FGF5, EGF, E2F2, PIK3CD, HRAS, FGF12, AKT3, PIK3R1, MDM2, KRAS, FGF2, RB1, AKT2",0.441291429466834,0,FALSE
+"H1975","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41512,1.29,0.135,1829,0.498,"CYP2C9, GSTT2, CYP2E1, ALDH3B1, CYP1B1, CYP2C8, GSTZ1, GSTO2, ALDH3B2, GSTK1",0.869666231504994,0.302770657240282,FALSE
+"H1975","Input","KEGG_MISMATCH_REPAIR",0.5466,1.7,0.0243,4075,0.281,"POLD4, POLD2, RPA3, PMS2, MLH1, SSBP1, RFC2, MSH6, EXO1, RPA1, PCNA",1.61439372640169,0.55129368009492,FALSE
+"H1975","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.25271,0.786,0.76,4088,0.957,"RPS6KB2, RPS6KA3, CAB39, HIF1A, MLST8, RPS6KA2, PRKAA1, RICTOR, PIK3R2, PIK3CA, STK11, TSC1, MAPK1, RHEB, PIK3CB",0.119186407719209,0.0190880622231565,FALSE
+"H1975","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.21448,0.663,0.921,4488,0.976,"VAV1, MAP2K2, RAC2, ARAF, KLRC1, RAC1, ICAM2, PRKCA, PAK1, ITGB2, SHC3, RAET1E, PIK3R2, ULBP3, RAET1L, ICAM1, PIK3CA, PPP3CA, NFATC3, SH3BP2, MAPK1, KIR2DL1, PIK3CB, IFNGR1, VAV2, PLCG2, RAET1G",0.0357403698031511,0.0105501823333082,FALSE
+"H1975","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.19263,0.599,0.969,2791,0.972,"GLP2R, P2RX6, GRIN2A, PTGER1, P2RX5, GIPR, GRIN1, CALCR, GABRD, TRPV1, P2RY6, F2RL1, FPR1, P2RY14, ADORA2B, EDNRA, ADORA2A, HRH1, GRIN2D, GABRB3, GRM6, NR3C1, CTSG, TBXA2R, P2RY2, MCHR1, F2R, LPAR2, TSPO",0.0136762229492347,0.0123337350737254,FALSE
+"H1975","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.25301,-0.925,0.526,17113,1,"FRS2, NFKBIA, IRAK3, CALML6, NTF3, TRAF6, CAMK2B, SHC2, CSK, PLCG1, NGFR, MAPK10, BCL2, PIK3CD, HRAS, TP73, MAP2K5, CAMK4, AKT3, PIK3R1, KRAS, ATF4, NFKBIB, NFKBIE, SORT1, AKT2, BEX3",0.279014255846261,0,FALSE
+"H1975","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.43901,1.37,0.0979,4413,0.498,"NAMPT, NNMT, NT5C2, PNP, NT5M, AOX1, NMRK1, BST1, NT5E, NMNAT1",1.00921730819686,0.302770657240282,FALSE
+"H1975","Input","KEGG_NITROGEN_METABOLISM",0.31586,0.989,0.45,2132,0.813,"CA9, GLS, CA12, GLUD1",0.346787486224656,0.0899094544059319,FALSE
+"H1975","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23487,-0.869,0.645,15780,1,"TNF, BIRC2, TNFAIP3, SUGT1, NOD2, TAB2, IKBKB, MAPK11, MAP3K7, IL1B, NFKBIA, TRAF6, NLRP3, CXCL1, NLRC4, MAPK10, CXCL8, BIRC3, HSP90B1, NFKBIB",0.190440285364732,0,FALSE
+"H1975","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.34581,1.07,0.335,3926,0.731,"XRCC4, XRCC6, MRE11, NHEJ1",0.474955192963155,0.13608262304214,FALSE
+"H1975","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.33082,-1.22,0.202,17577,1,"EGF, PLCG1, E2F2, PIK3CD, HRAS, RARB, FHIT, AKT3, CASP9, PIK3R1, KRAS, RB1, AKT2",0.694648630553376,0,FALSE
+"H1975","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.19857,0.624,0.952,6732,0.978,"SNW1, DTX3L, APH1A, DVL2, LFNG, MFNG, PSEN1, NOTCH1, CTBP2, JAG1, PSEN2, DVL1, EP300, NUMB, NOTCH2, RBPJ, DTX3, NCSTN, HES1, KAT2A, MAML1",0.0213630516155257,0.00966114521239857,FALSE
+"H1975","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.3761,1.17,0.228,4644,0.599,"ERCC6, POLD4, RAD23A, CETN2, CUL4B, POLD2, RPA3, CDK7, RFC2, POLE3, CCNH, POLE2, RPA1, MNAT1, PCNA, RAD23B, POLE4, ERCC8",0.642065152999546,0.222573177610689,FALSE
+"H1975","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.2515,0.799,0.765,5039,0.943,"FUT8, ALG10, MGAT5B, RFT1, MGAT2, MAN1B1, ALG1, ALG10B, DPM2, STT3A, MGAT4B, DAD1, ST6GAL1, ALG2, TUSC3, ALG12",0.116338564846382,0.0254883072626717,FALSE
+"H1975","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.23366,-0.855,0.608,9443,1,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, CAMK2A, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR2AE1, OR5AK2, GUCA1A, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR2A7, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, PDC, OR2T4, OR2T6, OR1L6, OR13C4, ADCY3, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, CAMK2G, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR2A1, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR8B12, OR9A4, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, CALM3, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR51E2, OR11H6, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR13A1, OR5M11, OR13G1, OR2L13, OR5K1, OR1M1, OR51B2, OR52D1, OR51I1, OR1J1, OR5P3, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, CALM2, OR8D2, OR2T33, OR1J2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, CALML5, OR4D1, OR8G1, OR4F15, OR52B6, CALML3, OR2A25, OR2D3, OR1Q1, OR8A1, OR10A6, OR2A2, OR8G5, OR11H4, OR10A4, OR51B4, CLCA2, OR2D2, OR2AG1, OR10A3, OR10A2, OR2A14, OR4F17, OR2W3, OR6A2, OR56B4, OR1L8, OR2L2, PDE1C, CALML6, PRKG1, CAMK2B, GNAL, PRKG2, OR2AG2, PRKACB",0.216096420727265,0,FALSE
+"H1975","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.54479,1.74,0.0115,3558,0.327,"FTCD, MTHFD1, SHMT1, SHMT2, MTR",1.93930215964639,0.485452247339714,FALSE
+"H1975","Input","KEGG_OOCYTE_MEIOSIS",0.3253,1,0.44,5253,0.814,"SMC1B, PPP2R1A, PPP1CA, PPP2R5E, YWHAH, CALM1, RPS6KA3, ADCY7, CCNB1, CUL1, PLK1, YWHAQ, PPP2R5C, RPS6KA2, CDC20, ITPR1, ESPL1, PRKACA, SMC1A, MAPK12, BUB1, YWHAE, PPP1CB, PPP3CA, SPDYA, MAPK1, SLK, AURKA, CDC27, ITPR3, CDC25C, PKMYT1, ANAPC2, SMC3, CAMK2D, BTRC",0.356547323513813,0.0893755951107988,FALSE
+"H1975","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.29778,0.925,0.554,4918,0.852,"GBA, MAN2B1, AGA, HEXB, NEU1, FUCA2, NEU3",0.25649023527157,0.0695604052332999,FALSE
+"H1975","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.34869,1.09,0.309,2987,0.692,"NDUFV1, COX8C, ATP6V0D2, UQCR11, NDUFS8, UQCR10, NDUFA7, ATP5F1B, LHPP, NDUFB7, COX6B2, ATP6V0D1, COX10, NDUFA11, NDUFA6, SDHA, NDUFS2, NDUFB2, NDUFS7, NDUFA3, COX15, SDHC, UQCRC1, ATP6V1D, ATP5F1D, ATP6V1F, NDUFB6, NDUFA8, ATP6V1E2",0.510041520575165,0.159893905543242,FALSE
+"H1975","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.55449,1.75,0.0126,3554,0.433,"GALNT15, GALNT9, GCNT1, GALNT6, GALNT10, GALNT12, GALNT18, GALNT2, C1GALT1, GALNT11, C1GALT1C1, B4GALT5, GALNT7, ST3GAL2",1.89962945488244,0.363512103646635,FALSE
+"H1975","Input","KEGG_P53_SIGNALING_PATHWAY",-0.23845,-0.889,0.558,16247,1,"MDM4, CDK6, CCNG1, RCHY1, APAF1, GADD45G, SESN3, CCND2, COP1, BID, GADD45A, ZMAT3, PIDD1, SESN2, BBC3, TP73, CASP9, CD82, SESN1, MDM2",0.253365801062421,0,FALSE
+"H1975","Input","KEGG_PANCREATIC_CANCER",-0.2403,-0.898,0.485,15778,1,"RAD51, VEGFD, CDC42, RAC3, BRCA2, CDK6, E2F3, IKBKB, EGF, E2F2, MAPK10, PIK3CD, ARHGEF6, AKT3, CASP9, PIK3R1, VEGFC, KRAS, RB1, AKT2",0.314258261397736,0,FALSE
+"H1975","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.33383,-1.25,0.163,15433,1,"PPCDC, PPCS, VNN2, VNN1, PANK4, PANK3",0.787812395596042,0,FALSE
+"H1975","Input","KEGG_PARKINSONS_DISEASE",0.2865,0.904,0.597,2969,0.865,"NDUFV1, COX8C, UQCR11, NDUFS8, UQCR10, NDUFA7, ATP5F1B, NDUFB7, COX6B2, PINK1, UBA7, NDUFA6, SDHA, NDUFS2, NDUFB2, NDUFS7, NDUFA3, SDHC, UQCRC1, ATP5F1D, SLC25A5, NDUFB6, UBE2L3, NDUFA8",0.224025668870631,0.0629838925351858,FALSE
+"H1975","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.38604,1.19,0.22,5708,0.597,"TLR5, TUBB3, ARPC1A, LY96, YWHAQ, ACTB, ARPC1B, TUBA4A, PRKCA, TUBB4B, TUBA1B, CDH1, WASL, TUBA1A, TUBA1C, RHOA, NCL, KRT18, ROCK2, ABL1, TUBB6, ITGB1, ARPC5L, ARPC4, CTTN, ACTG1",0.657577319177794,0.224025668870631,FALSE
+"H1975","Input","KEGG_PATHWAYS_IN_CANCER",0.19395,0.605,0.96,5225,0.976,"WNT9A, CSF1R, MAP2K2, FZD9, CCNA1, RAC2, EGLN3, MAX, MYC, BMP2, HSP90AA1, RALB, ARAF, PTEN, ITGA2B, LAMB3, TP53, MECOM, PPARD, DAPK3, FZD2, HIF1A, PPARG, TRAF3, EGLN1, RAC1, MLH1, CRK, FADD, NCOA4, RALA, DVL2, CASP8, PRKCA, PIAS4, MET, PIAS2, PIAS3, PIK3R2, TPM3, WNT7B, XIAP, LAMA3, MSH6, MITF, FGF1, APPL1, KITLG, CHUK, IKBKG, CKS1B, APC, TGFB2, CDH1, PIK3CA, EPAS1, RARA, GSK3B, BCR, STAT5B, RXRA, PTCH1, FGF13, CYCS, MAPK1, CTBP2, ITGA3, RHOA, PIK3CB, CDKN2B, TGFB3, FN1, DAPK1, GSTP1, FZD4, ETS1, PLCG2, BMP4, EGFR, RALBP1, RUNX1, ABL1, LAMB2, FH, SMAD4, ITGA2, RALGDS, LAMC2, BRAF, DVL1, CBLC, LAMC1, GLI3, ITGB1, EP300",0.0177287669604316,0.0105501823333082,FALSE
+"H1975","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39142,1.22,0.199,2379,0.569,"RPEL1, XYLB, AKR1B1, DHDH",0.701146923590293,0.244887733604929,FALSE
+"H1975","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.48807,1.49,0.044,1867,0.424,"ALDOA, PRPS2, FBP1, RBKS, PGLS, RPEL1, ALDOC, PRPS1",1.35654732351381,0.372634143407267,FALSE
+"H1975","Input","KEGG_PEROXISOME",0.25755,0.811,0.75,4950,0.946,"ACOX2, HACL1, ACSL4, PEX11G, PMVK, PEX19, DHRS4, ACAA1, PEX26, GSTK1, ACSL5, PEX11B, PXMP4, PAOX, DECR2, SLC25A17, CAT, PEX3, AGPS, AMACR, FAR1, EHHADH, CROT, CRAT, EPHX2, PEX2",0.1249387366083,0.0241088635982073,FALSE
+"H1975","Input","KEGG_PHENYLALANINE_METABOLISM",0.58904,1.84,0.0116,2497,0.654,"ALDH3B1, AOC2, NAA80, ALDH3B2, AOC3, MIF, MAOB, GOT2",1.93554201077308,0.184422251675733,FALSE
+"H1975","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.2887,0.9,0.584,5637,0.849,"DGKI, CALM1, CDS2, PTEN, PIP5K1C, DGKD, IMPA2, DGKG, PRKCA, PIP4K2C, INPP5J, PIP4K2A, ITPR1, PIK3R2, PI4KB, PIK3CA, CDIPT, INPP5K, PIK3C2A, PIK3CB, PLCG2, DGKE, PIK3C3, ITPR3, PLCE1, SYNJ2, DGKA, DGKZ, PI4KA",0.233587152887601,0.0710923097560473,FALSE
+"H1975","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.44685,1.39,0.0942,5437,0.474,"HMOX1, COX10, HMOX2, UROS, COX15, EARS2, CPOX, ALAD, HCCS, PPOX, HMBS, BLVRA, FTH1, UROD",1.02594909720712,0.324221658325915,FALSE
+"H1975","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.30184,0.942,0.524,4836,0.856,"ACOX2, PLTP, ACSL4, SLC27A5, SLC27A4, ANGPTL4, PPARD, ACAA1, PPARG, ACSL5, FABP5, SORBS1, CPT1C, RXRA, NR1H3, GK, SCD, EHHADH, CYP27A1, PDPK1",0.280668713016273,0.0675262353228468,FALSE
+"H1975","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45483,1.42,0.0761,995,0.508,"ACOX2, HSD3B7, SLC27A5",1.11861534322943,0.294136287716081,FALSE
+"H1975","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.386,1.22,0.201,5218,0.569,"CD79A, CD19, IL7R, CIITA, CD40, JAK3, IKBKG, ADA, TAP2, RFXANK, RFX5, LCK",0.696803942579511,0.244887733604929,FALSE
+"H1975","Input","KEGG_PRION_DISEASES",0.23302,0.728,0.831,3888,0.977,"MAP2K2, HSPA1A, ELK1, PRKACA, NOTCH1, PRNP, MAPK1",0.080398976215889,0.0101054362812269,FALSE
+"H1975","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21291,-0.794,0.738,17438,0.983,"CDC16, CPEB1, MAPK10, PIK3CD, PRKACB, ADCY1, ANAPC7, AKT3, ANAPC13, PDE3B, PIK3R1, ANAPC10, KRAS, ADCY6, AKT2",0.131943638176958,0.00744648216786438,FALSE
+"H1975","Input","KEGG_PROPANOATE_METABOLISM",0.41945,1.32,0.123,4878,0.514,"LDHC, LDHA, ALDH9A1, ECHS1, ACAT1, LDHAL6B, ALDH1B1, HADHA, PCCB, EHHADH, ACACA, SUCLG1",0.910094888560602,0.289036881004724,FALSE
+"H1975","Input","KEGG_PROSTATE_CANCER",-0.281,-1.08,0.277,16569,1,"E2F3, IKBKB, PDGFD, PDGFRA, NFKBIA, AR, FOXO1, EGF, E2F2, BCL2, PIK3CD, HRAS, FGFR2, AKT3, CASP9, LEF1, PIK3R1, MDM2, KRAS, HSP90B1, ATF4, RB1, AKT2",0.557520230935551,0,FALSE
+"H1975","Input","KEGG_PROTEASOME",0.40843,1.27,0.157,5843,0.503,"PSMC1, PSMF1, PSMA3, PSMC2, PSMB9, PSMD11, PSMD4, PSMD2, PSMB6, PSMA2, PSMB4, PSMD7, PSMB8, PSMD6, PSMD12, PSMB7, PSMD1, PSME1, PSMC5, SEM1, PSMB5, PSME2, PSME3, PSME4",0.804100347590766,0.298432014944073,FALSE
+"H1975","Input","KEGG_PROTEIN_EXPORT",-0.44499,-1.69,0.0282,15662,1,"SPCS3, SEC62, SEC11A, IMMP1L, SEC63, SRP14, SEC11C, IMMP2L, SPCS2",1.54975089168064,0,FALSE
+"H1975","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23675,-0.909,0.474,14779,1,"ATP1B2, MDH1, ATP1A1, FXYD2, SLC38A3, GLS2, CA2, ATP1B1, ATP1A3, PCK2",0.324221658325915,0,FALSE
+"H1975","Input","KEGG_PURINE_METABOLISM",0.32959,1.03,0.398,5239,0.785,"POLD4, IMPDH2, NME5, GUCY2D, PRPS2, HPRT1, PDE4A, POLD2, APRT, IMPDH1, ADCY7, AK4, AK7, POLR2E, PDE2A, NME7, PAPSS2, PFAS, ADK, PRPS1, POLR3H, POLR2J, AK1, NT5C2, PNP, POLR2F, GUK1, POLR3G, PRIM1, NT5M, POLR3A, NME2, PDE5A, ITPA, POLR2H, POLR3GL, POLE3, RRM2, POLE2, ENTPD5, ADSL, ADA, POLR1C, NT5E, NME3, NME6, POLR1E, POLE4, PDE6D, POLR1A, PKM, GMPR2, POLR3C, NPR1, NME1, ENTPD6, ENTPD3",0.400116927926312,0.105130343254747,FALSE
+"H1975","Input","KEGG_PYRIMIDINE_METABOLISM",0.41103,1.28,0.142,5239,0.494,"POLD4, CDA, NME5, UPP1, POLD2, POLR2E, NME7, POLR3H, POLR2J, NT5C2, PNP, POLR2F, UMPS, UPRT, CMPK2, POLR3G, TYMP, PRIM1, NT5M, UCK2, POLR3A, NME2, ITPA, POLR2H, DHODH, TK2, POLR3GL, POLE3, RRM2, POLE2, ENTPD5, POLR1C, NT5E, NME3, NME6, POLR1E, POLE4, POLR1A, CAD, POLR3C, DTYMK, NME1, ENTPD6, ENTPD3",0.847711655616944,0.306273051076353,FALSE
+"H1975","Input","KEGG_PYRUVATE_METABOLISM",0.51518,1.63,0.0254,3486,0.336,"LDHC, PC, LDHD, LDHA, ALDH9A1, MDH2, DLD, AKR1B1, PDHA1, ACAT1, LDHAL6B, ALDH1B1, ME3, HAGHL, PDHB",1.59516628338006,0.473660722610156,FALSE
+"H1975","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.27955,0.895,0.614,5366,0.852,"PPP1CA, VAV1, MAP2K2, MYLK2, LIMK1, PAK6, RAC2, GNA12, ARAF, ITGA5, ITGA2B, PAK2, ARPC1A, PIP5K1C, ITGB3, ACTN1, MYLK, RAC1, ACTB, CRK, ARPC1B, PIP4K2C, PAK1, ENAH, ITGB2, F2R, DIAPH1, TMSB4X, DIAPH2, IQGAP3, MYH9, MYL9, SSH3, MSN, PIP4K2A, ITGAE, RRAS2, MYL7, PIK3R2, FGF1, FGD1, MRAS, SSH2, CFL2, APC, TIAM1, PIK3CA, PPP1CB, WASL, FGF13, MAPK1, BCAR1, ITGA3, RHOA, PIK3CB, FN1, MYH10, VAV2, VCL, EGFR, ROCK2, IQGAP1, ITGA2, BRAF, DOCK1, GNA13, ITGB1, ITGAX, TIAM2, ARPC5L, ARPC4",0.211831628858832,0.0695604052332999,FALSE
+"H1975","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.22708,0.7,0.88,5419,0.959,"ATG7, ATG12, ATG4A, PIK3R4, PRKAA1, GABARAP, ATG3, PIK3C3, BECN1, ULK2",0.0555173278498314,0.0181813928293364,FALSE
+"H1975","Input","KEGG_RENAL_CELL_CARCINOMA",0.26049,0.825,0.715,4320,0.926,"MAP2K2, PAK6, EGLN3, ARAF, PAK2, HIF1A, FLCN, EGLN1, RAC1, CRK, PAK1, MET, PIK3R2, TGFB2, PIK3CA, EPAS1, MAPK1, PIK3CB, TGFB3, ETS1",0.145693958198919,0.0333890133180656,FALSE
+"H1975","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.5803,1.82,0.00927,1975,0.487,"ANPEP, THOP1, AGT, CTSA, NLN, CTSG",2.0329202658555,0.312471038785366,FALSE
+"H1975","Input","KEGG_RETINOL_METABOLISM",0.30349,0.951,0.511,2503,0.853,"CYP2C9, CYP2C8, AWAT2, RDH11, DHRS4, CYP26B1, RETSAT, DHRS4L2",0.291579099865287,0.069050968832477,FALSE
+"H1975","Input","KEGG_RIBOFLAVIN_METABOLISM",0.42251,1.31,0.134,2422,0.521,"ACP5, ACP6, FLAD1",0.872895201635192,0.283162276700476,FALSE
+"H1975","Input","KEGG_RIBOSOME",-0.18877,-0.702,0.89,16443,0.949,"RPS20, RPLP0, RPL9, RPL11, RPL6, RPS6, RSL24D1, RPL18, RPS27A, RPS8, RPL4, RPS4Y1, RPL21, RPL13A, RPS11, RPS16, RPS19",0.0506099933550872,0.0227337875727074,FALSE
+"H1975","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.36806,1.13,0.269,4513,0.663,"IL12B, MAVS, TRIM25, PIN1, ATG12, CYLD, TRAF3, FADD, ISG15, TRADD, CASP8, CASP10, DDX58, DHX58, RNF125, MAPK12, CHUK, IKBKG, MAPK13, TBKBP1, AZI2, DDX3X, NLRX1, RIPK1",0.570247719997592,0.178486471595227,FALSE
+"H1975","Input","KEGG_RNA_DEGRADATION",0.31907,1.01,0.418,7135,0.797,"LSM7, CNOT3, PAPOLA, LSM5, EDC4, CNOT4, HSPD1, MPHOSPH6, CNOT10, CNOT7, ENO1, XRN2, EXOSC7, CNOT6, PARN, EXOSC2, EXOSC3, SKIV2L, TTC37, LSM8, ENO2, EXOSC5, PATL1, LSM3, CNOT1, HSPA9, LSM4, EXOSC1, DCP1A, CNOT6L, ZCCHC7, PAPOLB",0.378823718224965,0.0985416786038876,FALSE
+"H1975","Input","KEGG_RNA_POLYMERASE",0.33649,1.06,0.367,4966,0.736,"POLR2E, POLR3H, POLR2J, POLR2F, POLR3G, POLR3A, POLR2H, POLR3GL, POLR1C, POLR1E, POLR1A, POLR3C",0.435333935747911,0.133122185662501,FALSE
+"H1975","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.31331,0.975,0.453,4567,0.83,"PAPSS2, HEMK1, AHCY, METTL6, METTL2B, SEPHS1, SCLY, GGT7",0.343901797987168,0.0809219076239261,FALSE
+"H1975","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.32651,-1.22,0.182,16569,1,"E2F3, IKBKB, APAF1, PTGS2, PIAS1, LAMA5, COL4A4, NFKBIA, TRAF6, LAMA2, LAMC3, LAMA1, E2F2, BCL2, PIK3CD, RARB, FHIT, PTK2, AKT3, LAMA4, CASP9, BIRC3, PIK3R1, COL4A1, RB1, COL4A2, LAMB1, AKT2",0.739928612014925,0,FALSE
+"H1975","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.42031,1.3,0.117,4374,0.501,"VTI1B, STX10, USE1, STX8, VTI1A, VAMP7, YKT6, SNAP47, VAMP8, STX4, SNAP29, STX1A, SNAP23, STX3, STX1B",0.931814138253838,0.300162274132754,FALSE
+"H1975","Input","KEGG_SPHINGOLIPID_METABOLISM",0.35951,1.12,0.288,7055,0.678,"SPTLC2, GALC, SGPP1, SPHK1, PLPP2, SGMS2, SGMS1, GBA, GLA, SMPD4, UGCG, NEU1, NEU3, KDSR, PLPP3, B4GALT6, ASAH2, SPTLC1, SGPL1, SMPD1, ARSA",0.540607512240769,0.168770306132937,FALSE
+"H1975","Input","KEGG_SPLICEOSOME",0.33022,1.02,0.393,5449,0.791,"PRPF31, SNW1, CTNNBL1, LSM7, RBM8A, ISY1, PQBP1, PRPF8, DHX38, HNRNPM, SNU13, HSPA1A, LSM5, PLRG1, U2AF2, SNRPB, RBM25, SRSF6, NCBP1, HSPA2, SF3B3, EFTUD2, CRNKL1, PRPF4, U2SURP, HSPA1B, HSPA8, BUD31, PPIL1, SLU7, DDX46, PRPF19, SNRPB2, SF3B4, SRSF1, SRSF5, SMNDC1, PRPF3, SF3A2, HNRNPK, XAB2, LSM8, PRPF6, SNRPD3",0.405607449624573,0.101823516502323,FALSE
+"H1975","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.38786,1.21,0.2,4362,0.57,"GCK, PGM2L1, PYGL, HK2, PYGB, GBE1, PGM2, UGDH, HK1",0.698970004336019,0.244125144327509,FALSE
+"H1975","Input","KEGG_STEROID_BIOSYNTHESIS",0.35022,1.09,0.325,1600,0.692,"LIPA, SOAT1, NSDHL",0.488116639021126,0.159893905543242,FALSE
+"H1975","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.29429,0.926,0.566,1748,0.858,"CYP11B1, CYP1B1, HSD17B6, STS",0.247183568811729,0.0665127121512946,FALSE
+"H1975","Input","KEGG_SULFUR_METABOLISM",0.30808,0.959,0.502,5223,0.843,"SULT1A4, PAPSS2, CHST11, SUOX, CHST12, SULT2B1, BPNT1",0.299296282854981,0.0741724253752577,FALSE
+"H1975","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.37457,1.19,0.218,3754,0.597,"GRIN2A, C4B, C4A, C3, ACTN1, CTSG, CD40, SNRPB, TRIM21, C1R",0.661543506395395,0.224025668870631,FALSE
+"H1975","Input","KEGG_TASTE_TRANSDUCTION",-0.1951,-0.719,0.847,12258,0.997,"TAS2R41, TAS2R8, PLCB2, PRKACG, GRM4, TAS1R2, TAS2R20, SCNN1A, ADCY8, TAS2R39, SCNN1G, GNAS, SCNN1B, TAS2R3, TAS2R38, TAS2R1, ASIC2, ADCY4, PDE1A, TAS2R46, TAS2R31, TAS2R10, TAS2R43, PRKACB, GNB1, ADCY6",0.0721165896692931,0.00130484168834428,FALSE
+"H1975","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.28783,-1.07,0.3,13732,1,"BAAT, GGT5, GGT6, CDO1",0.522878745280338,0,FALSE
+"H1975","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.31798,0.99,0.442,2018,0.82,"PMVK, ACAT1",0.354577730650908,0.0861861476162833,FALSE
+"H1975","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28547,0.901,0.618,6241,0.855,"PPP2R1A, RPS6KB2, THBS3, AMH, SMURF1, NOG, MYC, BMP2, CUL1, RBL1, TGFB2, LTBP1, MAPK1, RHOA, E2F4, CDKN2B, TGFB3, BMPR1B, BMP4, ID4, ROCK2, SMAD4, BMPR2, EP300, SMAD3, SKP1, TGFBR1, ACVR2B, THBS1, BMPR1A, PPP2R1B, TGFBR2, ACVR1",0.209011524911184,0.0680338852718274,FALSE
+"H1975","Input","KEGG_THYROID_CANCER",0.35496,1.09,0.329,3888,0.692,"MAP2K2, MYC, TP53, PPARG, NCOA4, TPM3, CDH1, RXRA, MAPK1",0.482804102050026,0.159893905543242,FALSE
+"H1975","Input","KEGG_TIGHT_JUNCTION",-0.18358,-0.669,0.937,16463,0.923,"EPB41, SYMPK, ACTN2, VAPA, IGSF5, MAGI2, CSNK2B, PARD6B, HCLS1, JAM2, PPP2CA, PPP2R2B, PRKCQ, EPB41L3, HRAS, PPP2R2C, MYL12B, AMOTL1, JAM3, RAB3B, AKT3, PARD6A, CLDN1, KRAS, MPDZ, AKT2",0.0282604091122217,0.0347982989740879,FALSE
+"H1975","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.27278,0.862,0.663,4088,0.883,"IL12B, TLR5, MAP2K2, TICAM2, LY96, TRAF3, RAC1, MAP2K4, FADD, IRAK1, IRF5, CASP8, CD40, MAP2K7, IRAK4, PIK3R2, MAPK12, CHUK, IKBKG, PIK3CA, TAB1, MYD88, MAPK1, MAPK13, TICAM1, PIK3CB",0.178486471595227,0.0540392964224314,FALSE
+"H1975","Input","KEGG_TRYPTOPHAN_METABOLISM",0.43105,1.34,0.125,4414,0.517,"GCDH, CYP1B1, ALDH9A1, AADAT, ECHS1, ACAT1, MAOB, ALDH1B1, HADHA, AOX1, OGDH, CAT, MAOA, EHHADH, KYNU",0.903089986991944,0.286509456906058,FALSE
+"H1975","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29726,0.908,0.581,4362,0.883,"GCK, CACNA1B, CACNA1A, INSR, HK2, PIK3R2, IRS1, PIK3CA, MAPK1, PRKCD, PIK3CB, HK1",0.235823867609669,0.0540392964224314,FALSE
+"H1975","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.23394,0.732,0.833,112,0.979,"IL12B",0.0793549985932124,0.00921730819686218,FALSE
+"H1975","Input","KEGG_TYROSINE_METABOLISM",0.44898,1.39,0.0809,3072,0.474,"ALDH3B1, GSTZ1, AOC2, NAA80, ALDH3B2, AOC3, MIF, HEMK1, MAOB, METTL6, GOT2, AOX1, METTL2B",1.09205147838773,0.324221658325915,FALSE
+"H1975","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17955,-0.702,0.931,15555,0.949,"FYN, NRAS, PAK3, TNF, CDC42, IL5, PPP3R1, IKBKB, MAPK11, CD4, MAP3K7, NFKBIA, PLCG1, NCK2, PRKCQ, PIK3CD, HRAS, AKT3, PIK3R1, PAK4, KRAS, NFKBIB, NFKBIE, AKT2",0.0310503190186574,0.0227337875727074,FALSE
+"H1975","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.25737,0.8,0.74,6465,0.949,"UBA6, KEAP1, CUL4B, SMURF1, FZR1, PPIL2, HUWE1, STUB1, UBE2D1, UBA7, CUL1, FBXO2, UBE2F, BRCA1, UBE2S, UBE2D4, WWP2, PIAS4, TRIM37, CDC20, UBE2M, HERC4, PIAS2, PIAS3, UBE2L3, XIAP, UBE2C, ITCH, UBE2H, NHLRC1, UBE3C, MID1, PRPF19, UBE2E3, UBE2O, UBA1, UBE2Q1, CDC27, ERCC8, UBE2L6, ANAPC2, CBLC, BTRC, CUL7, CDC34, FBXO4, TRIM32, ANAPC1, UBE2K, SKP1, SIAH1, TRIP12, SOCS3, NEDD4L, MGRN1, BIRC6, UBE4A, UBE2I, CDC26, UBE2G1, CDC23",0.130768280269024,0.0227337875727074,FALSE
+"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.56066,1.74,0.0163,3486,0.327,"LARS2, IARS2, PDHA1, PDHB",1.78781239559604,0.485452247339714,FALSE
+"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.45051,1.41,0.0795,4656,0.487,"ALDH9A1, HIBADH, ACAA1, DLD, ECHS1, ACAT1, ALDH1B1, HADHA, AOX1, IVD, OXCT1, HSD17B10, PCCB, ACADSB, EHHADH, MCCC2, ACAA2",1.09963287134353,0.312471038785366,FALSE
+"H1975","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.23538,0.737,0.854,4060,0.98,"PPP1CA, RAMP1, MAP2K2, MYLK2, PLA2G2C, CALM1, GNA12, ARAF, ADCY7, GNA11, ADORA2B, EDNRA, ADORA2A, MYLK, PRKCA, MYL9, ITPR1, PRKACA, PPP1CB, CALD1, MYL6, MAPK1, PRKCD, PLA2G12A, RHOA",0.068542129310995,0.00877392430750515,FALSE
+"H1975","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.3188,0.995,0.445,6423,0.817,"CREB3L3, CREB3L1, DYNC1H1, RAB11B, DYNC2H1, DYNLL2, PRKACA, CREB5, STX4, DCTN2, CREB3L2, CREB3L4, NSF, CREB1, DYNC1LI1, DYNC1I2, RAB5C, DCTN1, RAB5B, PRKX, ADCY9",0.351639989019068,0.0877779434675845,FALSE
+"H1975","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23242,0.721,0.862,4088,0.971,"NOS3, MAP2K2, PLA2G2C, RAC2, MAPKAPK3, HSPB1, RAC1, SPHK1, PRKCA, PIK3R2, MAPK12, PIK3CA, PPP3CA, NFATC3, MAPK1, MAPK13, PLA2G12A, PIK3CB",0.0644927341752872,0.0127807700919951,FALSE
+"H1975","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.27487,0.854,0.674,6423,0.891,"ATP6V0D2, ERO1A, ATP6V0D1, TJP2, ACTB, PRKCA, ATP6V1D, PRKACA, ATP6V1F, ATP6V1E2, TCIRG1, ATP6V0E2, PLCG2, KDELR3, SEC61G, ARF1, ATP6V1E1, SEC61A1, TJP1, ATP6V0E1, ACTG1, PDIA4, ATP6V1C1, ATP6V1B2, PRKX, KDELR2, ADCY9",0.17134010346468,0.0501222959631252,FALSE
+"H1975","Input","KEGG_VIRAL_MYOCARDITIS",0.32969,1.03,0.388,4251,0.785,"MYH15, RAC2, RAC1, ACTB, ABL2, CASP8, CD40, ITGB2, CAV1, MYH9, EIF4G1, ICAM1, CYCS, DAG1, MYH10",0.411168274405793,0.105130343254747,FALSE
+"H1975","Input","KEGG_WNT_SIGNALING_PATHWAY",0.20679,0.648,0.939,4060,0.982,"WNT9A, PPP2R1A, PPP2R5E, PRICKLE2, FZD9, RAC2, MYC, DAAM1, TP53, PPARD, FZD2, CUL1, PRICKLE1, TBL1X, RAC1, PPP2R5C, DVL2, PRKCA, RUVBL1, PRKACA, PSEN1, WNT7B, APC, PPP3CA, GSK3B, NFATC3, CTBP2, FOSL1, DKK1, RHOA",0.0273344077338891,0.00788851221305034,FALSE
+"H1648","Input","KEGG_ABC_TRANSPORTERS",0.39832,1.22,0.187,4466,0.62,"ABCC5, ABCA12, ABCC2, ABCB9, ABCA7, ABCA13, ABCC3, ABCB6, ABCD1, TAP2, ABCA1, ABCB11, ABCC1, ABCG1",0.728158393463501,0.207608310501746,FALSE
+"H1648","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.38703,1.16,0.229,5702,0.672,"IKBKB, PML, JUP, BRAF, PIK3CB, RUNX1, EIF4EBP1, MAP2K1, RPS6KB2, BAD, NFKB1, PIK3CA, MYC, MTOR, IKBKG, PIM1, STAT5A, CEBPA, RELA, RAF1, STAT5B, TCF7, CCND1, MAP2K2",0.640164517660112,0.172630726946175,FALSE
+"H1648","Input","KEGG_ADHERENS_JUNCTION",-0.25687,-0.941,0.465,17254,0.798,"FER, RHOA, CTNNA1, SSX2IP, TCF7L1, PTPRM, FYN, WASF3, NECTIN3, TGFBR1, FGFR1, WASF2, CDC42, SMAD2",0.332547047110046,0.0979971086492706,FALSE
+"H1648","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.30752,0.92,0.583,5333,1,"NFKBIA, IKBKB, TRADD, NFKBIE, MAPK9, ACSL5, TRAF2, TNFRSF1B, MAPK10, TNF, NFKB1, CAMKK1, STK11, RXRA, MTOR, IKBKG, RELA, IRS1, PRKAB1, CPT1C, CAMKK2, CPT1A, ACSL1",0.234331445240986,0,FALSE
+"H1648","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39667,1.17,0.236,4648,0.672,"IL4I1, NIT2, GLUD1, GAD1, ASL, DDO, ACY3, GLUL, ASS1, CAD, GLS2",0.627087997029893,0.172630726946175,FALSE
+"H1648","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.42261,1.27,0.141,5399,0.596,"SCNN1G, SCNN1B, SCNN1A, PIK3CB, SLC9A3R2, SFN, PIK3CA, HSD11B1, HSD11B2, INSR, ATP1B3, IRS1, ATP1A3, ATP1B1",0.85078088734462,0.224753740259764,FALSE
+"H1648","Input","KEGG_ALLOGRAFT_REJECTION",0.27671,0.827,0.734,2957,1,"CD40, TNF",0.134303940083929,0,FALSE
+"H1648","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.37999,1.14,0.269,5121,0.688,"PLA2G4E, PLA2G4B, PLA2G10, PLA2G12A, PLA2G2F, ACOX1",0.570247719997592,0.162411561764489,FALSE
+"H1648","Input","KEGG_ALZHEIMERS_DISEASE",-0.25911,-0.907,0.524,17647,0.826,"UQCRQ, ITPR2, NDUFB3, PLCB4, COX7A2, ATF6, NDUFA8, NDUFA7, NDUFA4, NDUFS4, GNAQ, CALM3, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APBB1, APAF1, COX6B1, PPP3CB, BACE1, NDUFB2, SDHC, PPP3R1, ATP5MC2, NDUFS5",0.280668713016273,0.0830199526796178,FALSE
+"H1648","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.33516,-1.17,0.223,16304,0.632,"VARS2, IARS2, NARS2, SARS2, WARS2, PSTK, RARS2, FARS2",0.651695136951839,0.199282921717615,FALSE
+"H1648","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.22266,-0.843,0.757,16450,0.853,"PMM2, NANP, GMPPA, NANS, PMM1, CYB5R3, GNPDA2, GFPT1, UGP2, UAP1",0.120904120499927,0.069050968832477,FALSE
+"H1648","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.2113,-0.756,0.819,18004,0.914,"BCL2, ALS2, MAP2K6, MAPK14, APAF1, PPP3CB, PPP3R1",0.0867160982395816,0.0390538042661686,FALSE
+"H1648","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.32656,0.981,0.458,5251,0.936,"PSME2, CD74, CTSS, PSME1, CIITA, CANX, IFI30, B2M, TAP2, HSPA1B, HSPA1A, LGMN, TAPBP, PSME3, HSPA4, CTSB, TAP1",0.339134521996131,0.0287241512618947,FALSE
+"H1648","Input","KEGG_APOPTOSIS",0.36086,1.09,0.326,4360,0.756,"NFKBIA, IRAK2, BIRC3, IKBKB, IL1A, TRADD, DFFA, CAPN1, PIK3CB, TNFRSF10A, CHP2, TRAF2, IRAK1, MAP3K14, BAD, TNF, MYD88, NFKB1, IL1R1, PRKAR1B, PIK3CA, TNFSF10, TNFRSF10D, TNFRSF10C, CYCS, IKBKG, CFLAR, TNFRSF10B",0.486782399932061,0.121478204498793,FALSE
+"H1648","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.54704,1.63,0.0244,4164,0.694,"CYP4F3, PLA2G4E, CYP2E1, GPX2, GGT6, CYP2J2, PTGS1, AKR1C3, LTC4S, GGT1, GPX3, PLA2G4B, PLA2G10, CYP2C18, LTA4H, GGT7, PTGES2, ALOX12B, EPHX2, CBR3, CBR1, PLA2G12A",1.61261017366127,0.158640529545145,FALSE
+"H1648","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.33383,1.01,0.427,4888,0.885,"PYCR3, AMD1, CKMT1A, CKMT1B, SAT1, GLUD1, AZIN2, ASL, NOS3, PRODH, GLUL, OAT, MAOA, AOC1, ASS1, GLS2, ALDH3A2, NAGS",0.369572124974976,0.0530567293021746,FALSE
+"H1648","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.25143,0.765,0.812,3332,1,"ITGB6, CACNB1, ITGA2, JUP, ITGB4, ITGB8, DSC2, LAMA2, PKP2, CACNA1F, CACNB4, DSP, ITGAV, DSG2",0.0904439707588247,0,FALSE
+"H1648","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32225,-1.14,0.282,18443,0.593,"ALDH1B1, ALDH9A1",0.549750891680639,0.226945306635737,FALSE
+"H1648","Input","KEGG_ASTHMA",0.29661,0.882,0.636,2957,1,"CD40, TNF",0.196542884351586,0,FALSE
+"H1648","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.24092,0.716,0.869,1371,0.997,"CD40, TSHB",0.0609802235513335,0.00130484168834428,FALSE
+"H1648","Input","KEGG_AXON_GUIDANCE",0.26975,0.807,0.761,3063,1,"RND1, PLXNA1, NCK1, MET, SEMA4A, NFATC4, PAK6, SEMA7A, SRGAP3, EPHB3, SEMA4B, EPHA1, PLXNB3, PAK2, RAC2, CHP2, PLXNA2, UNC5A, SEMA3B, EPHA2, PLXNB1, PAK1, ABLIM3, RHOD, EFNA1, LIMK2, PTK2, PLXNB2",0.118615343229427,0,FALSE
+"H1648","Input","KEGG_BASAL_CELL_CARCINOMA",0.23492,0.717,0.879,2540,1,"WNT9A, DVL1, DVL3, WNT7A, WNT10A, BMP2, FZD5",0.0560111249262281,0,FALSE
+"H1648","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.3335,-1.18,0.196,17073,0.694,"GTF2B, GTF2A1, TAF9, STON1, TAF1, TAF11, TAF9B, TAF12",0.707743928643524,0.158640529545145,FALSE
+"H1648","Input","KEGG_BASE_EXCISION_REPAIR",0.4702,1.41,0.0768,5907,0.494,"MUTYH, POLB, NEIL1, MBD4, POLL, PARP3, POLD4, SMUG1, PARP2, POLE2, UNG, POLE, APEX1, OGG1",1.11463877996849,0.306273051076353,FALSE
+"H1648","Input","KEGG_BETA_ALANINE_METABOLISM",-0.36707,-1.32,0.156,18214,0.733,"HIBCH, SMS, ACADM, ALDH1B1, ALDH9A1",0.806875401645538,0.134896025358872,FALSE
+"H1648","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.32236,-1.19,0.209,17624,0.78,"ELOVL2, FADS2, ACOT7, HACD1",0.679853713888946,0.10790539730952,FALSE
+"H1648","Input","KEGG_BLADDER_CANCER",0.45711,1.4,0.0881,1484,0.474,"MMP9, FGFR3, E2F1, CXCL8, MMP1, CDH1, EGF, VEGFC, BRAF",1.05502409158795,0.324221658325915,FALSE
+"H1648","Input","KEGG_BUTANOATE_METABOLISM",0.24511,0.735,0.85,2914,1,"AKR1B10, BDH1, L2HGDH, GAD1, AACS",0.0705810742857073,0,FALSE
+"H1648","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.39009,1.16,0.248,4804,0.672,"NFKBIA, CARD11, IKBKB, DAPP1, LYN, PLCG2, NFATC4, NFKBIE, PIK3CB, RAC2, PTPN6, CHP2, PIK3AP1, MAP2K1, VAV1, SYK, NFKB1, PIK3CA, BLNK, BCL10, IKBKG, NFATC2, VAV3, RAC1, RELA, NFAT5, CD72",0.605548319173784,0.172630726946175,FALSE
+"H1648","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.27697,0.846,0.689,3884,1,"DRD5, HTR7, LTB4R2, VDAC3, GNA15, PTAFR, P2RX5, PLCG2, ADRA1B, ADRB2, CALML6, GRIN2D, RYR3, ADCY4, CHP2, PLCB3, GRIN1, CHRM3, PTK2B, ADORA2A, P2RX6, SLC25A5, NOS3, CACNA1F, SLC25A31, ADCY3, SPHK1, CALML5, ERBB3, PHKG2, P2RX4, ATP2A2, ITPR3",0.161780778092374,0,FALSE
+"H1648","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.20876,0.629,0.952,2974,1,"UQCRFS1, COX6B2, CACNB1, TNNI3, COX5A, CYC1, UQCRHL, CACNA1F, CACNB4, UQCRB",0.0213630516155257,0,FALSE
+"H1648","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.42651,1.28,0.136,2286,0.604,"CLDN18, CD6, ITGAM, CLDN9, SELL, SELP, CLDN10, CLDN8, NECTIN1, ICOSLG, CDH3, CLDN20, CD40, ITGB2, CDH1, CLDN7, CLDN3, ITGB8, CLDN23, CLDN4, NRCAM, ICAM2, CLDN1, OCLN, SDC1",0.866461091629782,0.218963061378868,FALSE
+"H1648","Input","KEGG_CELL_CYCLE",-0.28219,-1.05,0.389,16874,0.712,"MAD2L2, CDC23, CDC25B, CCND2, E2F2, CDKN2D, SMC3, YWHAE, ABL1, ORC3, BUB3, SMC1A, SKP1, SKP2, CCNH, CDKN2B, RBX1, DBF4, CDKN2A, ORC2, CDKN2C, TFDP1, ANAPC13, CDC25C, CDC16, ANAPC10, SMAD2",0.410050398674292,0.147520006363144,FALSE
+"H1648","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.41843,1.26,0.156,3342,0.574,"CXCL10, CXCL9, CXCL11, CXCL6, CXCL3, CX3CL1, CCL5, NFKBIA, CCL22, CCR3, CXCL1, CXCL2, CCL20, IKBKB, LYN, CCL28, PF4, CCL17, CXCL8, GRK6, CCL19, FOXO3, CXCL16, BRAF, PIK3CB, GRK7, PPBP, CCL3, RAC2, GRK2, ADCY4, PLCB3, MAP2K1, PTK2B, VAV1, PAK1, CCL26, ADCY6, PRKCZ, TIAM1, PTK2, CSK, ADCY3, NFKB1, CXCR6, STAT2, CCR7, CCL3L3",0.806875401645538,0.241088107602027,FALSE
+"H1648","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.33339,1.01,0.424,5756,0.885,"NFKBIA, IKBKB, E2F1, BCR, SMAD3, BRAF, PIK3CB, RUNX1, CBLC, MAP2K1, HDAC2, MECOM, BAD, TGFB3, NFKB1, PIK3CA, MYC, TGFBR2, IKBKG, STAT5A, RELA, TGFB2, CDK6, RAF1, HDAC1, STAT5B, BCL2L1, TGFB1, CCND1, MAP2K2, SHC2",0.372634143407267,0.0530567293021746,FALSE
+"H1648","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.47974,1.43,0.0727,3056,0.549,"NR1D1, BHLHE41, BHLHE40, PER1, CSNK1E",1.13846558914096,0.260427655549908,FALSE
+"H1648","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.31856,-1.14,0.235,18284,0.593,"MDH1, OGDH, ACO1, SDHC",0.628932137728264,0.226945306635737,FALSE
+"H1648","Input","KEGG_COLORECTAL_CANCER",-0.23639,-0.806,0.763,17100,0.864,"AXIN2, RHOA, APC, TCF7L1, BCL2, PIK3R1, AKT3, TGFBR1, MAPK8, SMAD2",0.11747546204512,0.0634862575211067,FALSE
+"H1648","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.37195,1.12,0.263,4100,0.719,"C9, CFB, THBD, PROC, C5AR1, PLAU, SERPINF2, VWF, PLAT, C3, F5, F3, F12, FGG, PLAUR, SERPINA5, CFH, SERPINA1",0.580044251510242,0.143271109617117,FALSE
+"H1648","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.28336,0.855,0.685,879,1,"AHCY, IL4I1, AMD1, SDS",0.164309428507574,0,FALSE
+"H1648","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.51645,1.56,0.0392,3922,0.635,"CXCL10, IFNL1, IFNL3, CRLF2, IFNB1, CXCL9, CXCL11, IFNL2, CXCL6, CXCL3, CX3CL1, CCL5, IL23A, CCL22, IFNGR1, CSF2, CCR3, IL1R2, LTB, CXCL1, TNFSF18, CD27, TNFRSF18, CXCL2, CCL20, CSF3, IL20RA, CCL28, PF4, IL9R, CCL17, MET, CXCL8, IL1A, BMPR1B, IL4R, CD40, CCL19, TNFRSF21, CXCL16, BMP7, EGF, VEGFC, IL15RA, TNFRSF10A, TNFSF13, CSF2RA, PPBP, CCL3, IL6, BMP2, IL18, IL10RB, INHBE, TNFRSF14, TNFRSF1B, IFNLR1, CSF1, IL19, CCL26, PDGFB, AMH, NGFR, TNFSF15, TNF, PDGFA, TGFB3, CXCR6, IL1R1, CCR7, IL20RB, CSF1R, CCL3L3, TNFSF14, LTBR, IL22RA1, IFNAR2, LIF, RELT, TGFBR2, INHBB, TNFSF10, TNFRSF10D",1.40671393297954,0.197226274708024,FALSE
+"H1648","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.56446,1.67,0.0213,2184,0.92,"CXCL10, IFNB1, RIPK3, CCL5, NFKBIA, DDX58, IKBKE, IKBKB, IRF7, IL6, IRF3, IL18",1.67162039656126,0.0362121726544447,FALSE
+"H1648","Input","KEGG_DILATED_CARDIOMYOPATHY",0.22268,0.666,0.927,3111,1,"ITGB6, CACNB1, TNNI3, ITGA2, ITGB4, ITGB8, ADCY4, LAMA2, ADCY6, CACNA1F, CACNB4, TNF, ITGAV, TGFB3, ADCY3",0.0329202658555029,0,FALSE
+"H1648","Input","KEGG_DNA_REPLICATION",0.272,0.83,0.734,5279,1,"RNASEH2C, RNASEH1, RFC4, POLD4, MCM2, RPA4, MCM5, MCM7, POLE2, RFC5, POLA2, POLE",0.134303940083929,0,FALSE
+"H1648","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.39202,1.17,0.216,2350,0.672,"ETV6, ETV7, PIWIL4, NOTCH3, MAP2K1",0.665546248849069,0.172630726946175,FALSE
+"H1648","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.31734,0.955,0.512,5269,0.965,"ADH7, CYP2E1, ALDH3A1, CYP2D6, ALDH1A3, GSTM1, GSTO2, CYP2C18, GSTT2, GSTK1, ALDH3B2, MGST1, MAOA, ADH1A, GSTP1, MGST2, GSTM3",0.290730039024169,0.0154726866562074,FALSE
+"H1648","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.33408,0.999,0.445,4726,0.906,"XDH, UMPS, NAT1, UPP1, HPRT1, GMPS, GUSB, UCKL1, TYMP, CDA, IMPDH1",0.351639989019068,0.0428718023231869,FALSE
+"H1648","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.28407,0.858,0.671,3805,1,"ITGB6, LAMC2, CHAD, LAMA3, ITGA2, AGRN, LAMB3, CD47, ITGB4, ITGB8, VWF, SDC1, THBS4, LAMA2, ITGAV, SDC4, LAMA5, THBS1, HMMR",0.173277479831008,0,FALSE
+"H1648","Input","KEGG_ENDOCYTOSIS",0.323,0.971,0.485,4228,0.941,"ITCH, SRC, RAB11FIP1, CHMP4B, EPN3, TFRC, MET, FGFR3, CLTB, HGS, GRK6, SMURF1, ARAP1, ACAP3, EGF, ADRB2, ACAP2, ARAP3, RUFY1, GRK7, CHMP6, GRK2, VPS37B, PSD4, CBLC, RAB11FIP4, CHMP4C, IGF1R, IQSEC1, CLTA, ASAP2, ARAP2, VPS37C, PRKCZ, LDLR, CHMP4A, SH3GLB2, GIT1, ARF6, RAB11A, CSF1R, ERBB3, HSPA1B, AP2M1, HSPA1A, RAB22A, FGFR2, WWP1, ACAP1, AGAP2, DNM2",0.314258261397736,0.0264103765727431,FALSE
+"H1648","Input","KEGG_ENDOMETRIAL_CANCER",0.18238,0.545,0.986,3622,1,"CDH1, FOXO3, EGF, BRAF, PIK3CB, MAP2K1, BAD, PIK3CA, MYC",0.0061230850587888,0,FALSE
+"H1648","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.51814,1.55,0.0421,4862,0.534,"ATP6V0D2, CCL5, SRC, NFKBIA, ATP6V1C2, CXCL1, IKBKB, LYN, MET, CXCL8, PLCG2, ADAM17, MAPK9, TCIRG1, MAPK13, PTPRZ1, ATP6V0E1, HBEGF, TJP1, ATP6V0A2, PAK1, MAPK10, MAP3K14, ATP6V0B, F11R, ATP6V1H, CSK, NFKB1, GIT1, ATP6V0E2, NOD1, ATP6V1C1, ATP6V1A, IKBKG, ADAM10, RAC1, RELA, MAPK12, EGFR",1.37571790416433,0.272458742971444,FALSE
+"H1648","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.39761,1.19,0.2,3664,0.688,"SRC, EREG, NCK1, BTC, AREG, PLCG2, PAK6, EGF, BRAF, PIK3CB, MAPK9, PAK2, EIF4EBP1, HBEGF, CBLC, TGFA, MAP2K1, PAK1, MAPK10, RPS6KB2, BAD, PTK2, ERBB3, PIK3CA, MYC, MTOR",0.698970004336019,0.162411561764489,FALSE
+"H1648","Input","KEGG_ETHER_LIPID_METABOLISM",0.2868,0.869,0.664,5129,1,"PLA2G4E, LPCAT4, PLA2G4B, PLA2G10, PLPP3, PLPP2, PLA2G12A, AGPS, PLD2, PLA2G2F, LPCAT2, PLD1",0.177831920631982,0,FALSE
+"H1648","Input","KEGG_FATTY_ACID_METABOLISM",-0.23858,-0.878,0.562,18120,0.841,"HADH, ACADM, ALDH1B1, ACAA2, ECI2, ALDH9A1",0.250263684430939,0.0752040042020878,FALSE
+"H1648","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.31999,0.963,0.492,4757,0.953,"PLA2G4E, CSF2, LYN, PLCG2, PIK3CB, MAPK9, MAPK13, RAC2, PLA2G4B, PLA2G10, MAP2K1, VAV1, MAPK10, SYK, TNF, PIK3CA, PLA2G12A, LAT, PLA2G2F, VAV3, RAC1, PRKCD, MAPK12",0.30803489723264,0.0209070993616736,FALSE
+"H1648","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.26203,0.782,0.794,5129,1,"PLA2G4F, PLA2G4E, LYN, PLCG2, PIK3CB, RAC2, PLA2G4B, MAP2K1, VAV1, PAK1, ASAP2, SYK, PLPP3, RPS6KB2, LIMK2, PLPP2, SPHK1, ARF6, PIK3CA, MYO10, DNM2, LAT, PLD2, PLA2G4D, VAV3, RAC1, PRKCD, WASL, RAF1, PLD1",0.100179497572904,0,FALSE
+"H1648","Input","KEGG_FOCAL_ADHESION",0.25253,0.777,0.803,3032,1,"SRC, BIRC3, DIAPH1, ITGB6, MET, LAMC2, CHAD, LAMA3, ITGA2, LAMB3, PAK6, EGF, VEGFC, BRAF, PIK3CB, MAPK9, ITGB4, ITGB8, PAK2, RAC2, ARHGAP5, VWF, MAP2K1, VAV1, THBS4, LAMA2, CAV2, PAK1, IGF1R, MAPK10, PDGFB, BAD, ITGAV, PDGFA, PTK2",0.095284454721319,0,FALSE
+"H1648","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.48535,-1.71,0.029,12183,0.21,"GGH, ALPI, GCH1, DHFR, ALPG, ALPP, ALPL",1.53760200210104,0.677780705266081,TRUE
+"H1648","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.46895,1.41,0.087,5512,0.494,"AKR1B10, MTMR1, PFKL, FBP2, MPI, PFKFB4, ALDOC, GMPPB, PFKFB2, TPI1, KHK, ALDOA, GMDS, HK2, PFKFB3, AKR1B1, PFKP, HK1",1.06048074738138,0.306273051076353,FALSE
+"H1648","Input","KEGG_GALACTOSE_METABOLISM",0.39746,1.17,0.235,6475,0.672,"GLA, GALT, PFKL, GANC, GAA, GALE, HK2, AKR1B1, PGM2, PFKP, HK1, B4GALT2, HK3, B4GALT1",0.628932137728264,0.172630726946175,FALSE
+"H1648","Input","KEGG_GAP_JUNCTION",-0.2056,-0.74,0.806,14131,0.899,"PRKCB, MAPK1, TUBB6, DRD1, GNAS, TUBB2B, ADCY2, GUCY1B1, ADCY1, TUBB8, PDGFRA, DRD2, KRAS, GUCY1A2, MAPK7, TUBA3D, CDK1, TUBB4A, PRKG1, PDGFD, TUBA1B, PRKACA, PDGFRB, TUBA8, TUBB2A, ADCY9, PRKACB, ITPR2, PLCB4, TUBB3, LPAR1, TUBB, NRAS, GNAQ, GNAI1, TUBA1A",0.0936649581949093,0.0462403082667712,FALSE
+"H1648","Input","KEGG_GLIOMA",0.24531,0.743,0.847,3664,1,"E2F1, PLCG2, EGF, BRAF, PIK3CB, CALML6, TGFA, MAP2K1, IGF1R, PDGFB, PDGFA, CALML5, PIK3CA, MTOR",0.0721165896692931,0,FALSE
+"H1648","Input","KEGG_GLUTATHIONE_METABOLISM",0.44987,1.35,0.0964,3859,0.553,"G6PD, GPX2, GSS, GGT6, GSR, OPLAH, GGT1, PGD, GPX3, GSTM1, GSTO2, GSTT2, GCLM, GGCT, GGT7, GSTK1, MGST1",1.01592296609717,0.257274868695302,FALSE
+"H1648","Input","KEGG_GLYCEROLIPID_METABOLISM",0.36643,1.1,0.292,5958,0.739,"DGAT1, LIPG, GLA, MBOAT2, DGKQ, AGPAT3, DGKA, DGAT2, AKR1A1, PLPP3, GPAT3, PLPP2, DGKG, DGKE, MBOAT1, CEL, DGKH, ALDH3A2, AGPAT2, AKR1B1, AGPAT4, TKFC, GLYCTK, GPAT4",0.534617148551582,0.131355561605174,FALSE
+"H1648","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40692,1.23,0.177,4873,0.609,"PLA2G4E, PISD, LPCAT4, LYPLA1, PTDSS1, PCYT1A, CHKB, MBOAT2, PGS1, PLA2G4B, PLA2G10, DGKQ, AGPAT3, DGKA, PLPP3, GPAT3, PLPP2, DGKG, DGKE, MBOAT1, CDS1, PLA2G12A, GPD2, PCYT2, ACHE, DGKH, PLD2, PLA2G2F, LPCAT2, LYPLA2, AGPAT2",0.752026733638193,0.215382707367125,FALSE
+"H1648","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.32615,-1.18,0.208,16750,0.694,"CTH, DMGDH, PHGDH, PSPH, GNMT, GLDC, PSAT1, SRR",0.681936665037238,0.158640529545145,FALSE
+"H1648","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.3453,1.02,0.4,6874,0.88,"ADH7, ALDH3A1, ALDH1A3, PFKL, FBP2, AKR1A1, ALDOC, PKM, DLAT, ALDH3B2, GPI, TPI1, LDHAL6B, ALDOA, GAPDH, HK2, ALDH3A2, ADH1A, ACSS2, GALM, PGM2, PFKP, LDHB, HK1, ADH6, PGAM1, LDHA, HK3, ALDH2, PCK2, ALDH3B1, FBP1",0.397940008672038,0.0555173278498314,FALSE
+"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.36842,1.1,0.307,3293,0.739,"B4GALT7, CHST11, B3GALT6, DSE, XYLT2, CHST15, CSGALNACT1",0.512861624522813,0.131355561605174,FALSE
+"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.28866,0.863,0.664,3227,1,"HS3ST1, B4GALT7, HS6ST2, B3GALT6, XYLT2, EXT1",0.177831920631982,0,FALSE
+"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.34764,1.05,0.361,3626,0.839,"B3GNT7, CHST6, CHST4, FUT8, B4GALT4",0.442492798094342,0.0762380391712997,FALSE
+"H1648","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.43688,1.32,0.129,5562,0.572,"HYAL4, IDS, SGSH, GUSB, HGSNAT, HYAL3, HEXA, HYAL1, IDUA, NAGLU, HPSE",0.889410289700751,0.242603971206976,FALSE
+"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.19525,-0.735,0.804,14842,0.886,"ST3GAL2, ST8SIA1, ST8SIA5, B4GALNT1, ST6GALNAC3",0.0947439512515487,0.0525662781129492,FALSE
+"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.53022,1.57,0.0375,2720,0.686,"GLA, FUT2, B3GALT5, FUT1, A4GALT",1.42596873227228,0.163675884293248,FALSE
+"H1648","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.49605,1.46,0.0511,3986,0.535,"ABO, B3GNT3, FUT3, FUT2, B3GALT5, B3GNT4, B3GNT5, FUT1, FUT4, B4GALT4, ST3GAL4, GCNT2",1.29157909986529,0.271646217978772,FALSE
+"H1648","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.38619,1.17,0.227,4959,0.672,"PIGU, PIGB, PIGZ, PIGX, GPAA1, PIGQ, PIGS, PIGO, PIGL, PIGH, PIGW",0.643974142806877,0.172630726946175,FALSE
+"H1648","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.60637,-2.19,0,17388,0.066,"MTHFD2, HYI, MDH1, ACO1, GRHPR",Inf,1.18045606445813,TRUE
+"H1648","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.26855,0.808,0.784,5175,1,"MAP3K4, SRC, PLA2G4E, MAPK9, MAPK13, CALML6, ADCY4, PLA2G4B, PLCB3, PLA2G10, HBEGF, MAP2K1, PTK2B, MAPK10, ADCY6, CACNA1F, ADCY3, MMP14, CALML5, MAP3K2, ITPR3, PLA2G12A, LHB, PLD2, PLA2G2F, PRKCD, MAPK12, CAMK2G, EGFR, ADCY7, RAF1, PLD1, MAP3K1",0.105683937315562,0,FALSE
+"H1648","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.38487,1.15,0.253,2957,0.673,"IL1A, IL6, TNF",0.596879478824182,0.171984935776023,FALSE
+"H1648","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.21478,-0.746,0.855,16454,0.911,"BMP8A, BMP8B, HHIP, BMP6, PRKACA, WNT2B, GAS1, PRKACB, GLI2, SUFU, WNT5A, GLI3, CSNK1G3, RAB23",0.0680338852718274,0.0404816230270017,FALSE
+"H1648","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.42186,1.26,0.148,3286,0.574,"ITGAM, CSF2, IL1R2, CSF3, TFRC, IL9R, IL1A, ITGA2, IL4R, CSF2RA, IL6, CD9, CSF1, TNF, IL1R1, CSF1R",0.829738284605043,0.241088107602027,FALSE
+"H1648","Input","KEGG_HISTIDINE_METABOLISM",0.42285,1.27,0.133,4814,0.596,"LCMT1, ALDH3A1, ALDH1A3, TRMT11, HNMT, ACY3, ALDH3B2, HEMK1, MAOA, HAL, AOC1, ALDH3A2",0.876148359032914,0.224753740259764,FALSE
+"H1648","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.41424,1.26,0.168,3359,0.574,"EME1, RAD51B, RAD51, MUS81, XRCC2, RAD51D, MRE11, RAD54L, POLD4, RAD54B, RPA4",0.774690718274137,0.241088107602027,FALSE
+"H1648","Input","KEGG_HUNTINGTONS_DISEASE",-0.21836,-0.77,0.765,17299,0.91,"POLR2G, DCTN2, CLTCL1, CREB3L1, UQCRQ, RCOR1, HIP1, NDUFB3, PLCB4, PPARGC1A, COX7A2, AP2S1, BDNF, NDUFA8, CREB3L2, NDUFA7, NDUFA4, NDUFS4, GNAQ, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APAF1, COX6B1, NDUFB2, SDHC, DCTN1, ATP5MC2, NDUFS5",0.116338564846382,0.0409586076789064,FALSE
+"H1648","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.25701,0.772,0.794,3041,1,"ITGB6, CACNB1, TNNI3, ACE, ITGA2, ITGB4, ITGB8, IL6, LAMA2, CACNA1F, CACNB4, TNF, ITGAV, TGFB3",0.100179497572904,0,FALSE
+"H1648","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.27439,0.82,0.742,5554,1,"INPP4A, PLCG2, IPMK, PIK3CB, INPP4B, PLCB3, SYNJ2, PIK3C2B, IPPK, PIK3C2G, PIK3CA, OCRL, TPI1, ISYNA1, INPP5K, PIP4K2C, PLCD3, INPP5E, INPPL1",0.129596094720973,0,FALSE
+"H1648","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.21936,0.657,0.936,7068,1,"IKBKB, PYGL, BRAF, PIK3CB, MAPK9, MKNK1, CALML6, FOXO1, EIF4EBP1, FBP2, CBLC, MAP2K1, MAPK10, RPS6KB2, BAD, SH2B2, PRKCZ, CALML5, TRIP10, PTPRF, PRKAR1B, PHKG2, PIK3CA, MTOR, SOCS2, ACACA, INSR, MKNK2, IRS1, HK2, PRKAB1, INPP5K, SOCS1, PPP1R3D, PHKG1, RAF1, EXOC7, HK1, SOCS3, MAP2K2, SHC2, FASN, PHKA1, TSC2, SOS1, PRKCI, HK3, PRKAA1, CRKL, SOS2, GYS1, LIPE, INPP5D, PYGM, PRKAG2, PCK2, FBP1, FLOT2, PHKA2, CALM2",0.0287241512618947,0,FALSE
+"H1648","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.51136,1.53,0.0375,4573,0.458,"PIGR, CCL28, ICOSLG, CD40, IL15RA, TNFSF13, IL6, MAP3K14, LTBR, MADCAM1, IL15",1.42596873227228,0.339134521996131,FALSE
+"H1648","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.40928,1.23,0.167,4604,0.609,"IFNL1, IFNL3, CRLF2, IFNB1, IFNL2, IL23A, IFNGR1, CSF2, CSF3, IL20RA, IL9R, SPRY3, IRF9, IL4R, PIK3CB, IL15RA, CSF2RA, SPRY1, PTPN6, IL6, CBLC, IL10RB, IFNLR1, IL19, STAT6, TYK2, STAT2, IL20RB, PIK3CA, IL22RA1, MYC, IFNAR2, LIF, SOCS2, CCND3, IFNGR2, PIM1, JAK3, CLCF1, OSMR, STAT5A, IL15, SOCS7",0.777283528852417,0.215382707367125,FALSE
+"H1648","Input","KEGG_LEISHMANIA_INFECTION",0.46633,1.42,0.0834,3125,0.546,"ITGAM, NFKBIA, IFNGR1, TLR2, IL1A, NCF4, ITGB2, TAB2, MAPK13, PTPN6, C3, IRAK1, CYBA, TNF, TGFB3, MYD88, NFKB1",1.07883394936226,0.262807357295263,FALSE
+"H1648","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.42995,1.28,0.137,3977,0.604,"MMP9, CLDN18, ITGAM, CLDN9, CLDN10, CLDN8, NCF4, CLDN20, PLCG2, ITGB2, CLDN7, CTNND1, PIK3CB, CLDN3, AFDN, MAPK13, CLDN23, RAC2, CLDN4, ARHGAP5, CLDN1, OCLN, PTK2B, VAV1, EZR, RAPGEF3, F11R, CYBA, PTK2, SIPA1, PIK3CA, NOX1, NCF2, RASSF5, TXK, PXN",0.863279432843593,0.218963061378868,FALSE
+"H1648","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.5,-1.76,0.0197,18443,0.212,"ALDH1B1, ALDH9A1",1.70553377383841,0.673664139071249,TRUE
+"H1648","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.61142,1.85,0.0104,2088,0.461,"AKR1B10, PLA2G4E, CYP2E1, CYP2J2, PLA2G4B, PLA2G10, CYP2C18",1.98296666070122,0.336299074610352,FALSE
+"H1648","Input","KEGG_LONG_TERM_DEPRESSION",0.18565,0.558,0.991,2608,1,"PLA2G4E, LYN, BRAF, PLA2G4B, PLCB3, PLA2G10, MAP2K1, IGF1R",0.00392634551472468,0,FALSE
+"H1648","Input","KEGG_LONG_TERM_POTENTIATION",-0.27282,-1.01,0.438,16947,0.745,"CALM1, RAP1B, PRKACA, PRKACB, ITPR2, CAMK4, RPS6KA2, PLCB4, RPS6KA1, ATF4, NRAS, GNAQ, CALM3, PPP3CB, PPP3R1",0.3585258894959,0.127843727251707,FALSE
+"H1648","Input","KEGG_LYSINE_DEGRADATION",-0.29843,-1.09,0.3,17259,0.675,"SETDB1, EHMT1, HADH, ALDH1B1, AASS, OGDH, ALDH9A1, NSD1",0.522878745280338,0.170696227168975,FALSE
+"H1648","Input","KEGG_LYSOSOME",0.42184,1.25,0.179,6147,0.586,"CTSE, ATP6V0D2, AP3M2, GGA2, NAPSA, LAMP3, CTSS, GLA, LAPTM5, IDS, ABCB9, MANBA, CLTB, IGF2R, CD164, CTSH, GGA3, TCIRG1, AP3B2, GM2A, AP1S3, CTSV, ATP6V0A2, SGSH, CLTA, ATP6V0B, GUSB, SLC11A2, CTSA, ATP6V1H, AP4S1, AP1M2, HGSNAT, GAA, ENTPD4, MFSD8, SUMF1, CTSD, LGMN, ACP5, GNPTG, SORT1, HEXA, CTSB, HYAL1, IDUA, M6PR, MAN2B1, ATP6V0C, CTSC, NAGLU, ARSA, ARSG, NPC1, NPC2, AP3D1, PSAP, LAPTM4B, LIPA, GGA1, FUCA1, CLN5, CTSZ",0.747146969020107,0.232102383981909,FALSE
+"H1648","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.28446,0.853,0.67,3822,1,"MAP3K4, PLA2G4E, IL1R2, FGF17, IKBKB, DUSP5, CACNB1, DUSP10, NFKB2, FGFR3, DUSP9, NTF4, IL1A, GADD45A, FGF11, FGF13, NFATC4, RELB, RASGRP1, TAB2, EGF, BRAF, MAPK9, MAPK13, MKNK1, MAP3K13, PAK2, RAC2, MAP3K8, RPS6KA4, PLA2G4B, CHP2, PLA2G10, MAP2K1, RASA2, TRAF2, DUSP7, PAK1, MAPK10, MAP3K14, MAPKAPK5, MAPKAPK3, MECOM, CACNA1F, MAPK8IP3, CACNB4, PDGFB, GADD45B, TNF, PDGFA, TGFB3, NFKB1, IL1R1, STK3, MAP3K2, MAP3K5, MAP4K1, HSPA1B, MYC, MAP4K4, TGFBR2, HSPA1A, FGFR2",0.173925197299174,0,FALSE
+"H1648","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.43762,1.29,0.131,2498,0.614,"HES1, MNX1, HNF1B, HNF4G, FOXA2",0.882728704344236,0.211831628858832,FALSE
+"H1648","Input","KEGG_MELANOGENESIS",0.20532,0.614,0.961,3376,1,"WNT9A, DVL1, DVL3, WNT7A, WNT10A, CALML6, ADCY4, PLCB3, MAP2K1, FZD5, ADCY6, ASIP, ADCY3, CALML5, CREB3, FZD6",0.0172766123314547,0,FALSE
+"H1648","Input","KEGG_MELANOMA",0.30215,0.91,0.588,3017,1,"FGF17, MET, E2F1, FGF11, FGF13, CDH1, EGF, BRAF, PIK3CB, MAP2K1, IGF1R, PDGFB, BAD, PDGFA",0.230622673923862,0,FALSE
+"H1648","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43184,1.3,0.133,4142,0.606,"ADH7, CYP2E1, AKR1C2, CYP1A1, ALDH3A1, AKR1C3, ALDH1A3, GSTM1, GSTO2, CYP2C18, AKR1C1, GSTT2, CYP1B1, GSTK1, ALDH3B2, MGST1, CYP2S1",0.876148359032914,0.217527375833714,FALSE
+"H1648","Input","KEGG_MISMATCH_REPAIR",-0.19457,-0.731,0.872,19056,0.871,"RPA2",0.0594835150674328,0.0599818449923368,FALSE
+"H1648","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.26238,0.79,0.783,4058,1,"ULK1, RICTOR, VEGFC, BRAF, PIK3CB, EIF4EBP1, RPS6KB2, ULK3, STK11, PIK3CA, MTOR, HIF1A",0.106238237942057,0,FALSE
+"H1648","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.32157,0.953,0.509,4750,0.959,"IFNB1, IFNGR1, CSF2, PLCG2, ITGB2, NFATC4, BRAF, PIK3CB, SH3BP2, TNFRSF10A, RAC2, ICAM2, PTPN6, CHP2, MAP2K1, PTK2B, VAV1, PAK1, SYK, TNF, LCK, PIK3CA, IFNAR2, TNFSF10, TNFRSF10D, IFNGR2, TNFRSF10C, TNFRSF10B, LAT, NFATC2, CD244, VAV3, RAC1, NFAT5",0.293282217663241,0.0181813928293364,FALSE
+"H1648","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34881,1.04,0.37,2809,0.857,"DRD5, GALR2, NPBWR1, GABRP, S1PR4, HTR7, P2RY6, MC3R, P2RY2, LTB4R2, LTB4R, GABRG2, MTNR1A, PTAFR, P2RX5, C5AR1, GABRE, S1PR5, TSHB, ADRA1B, ADRB2, GRIN2D, SSTR2, GRIN1, VIPR1, CHRM3, ADORA2A, PRSS1, P2RX6, GRIN3B, GIPR, CHRNB1, GABRA3",0.431798275933005,0.0670191780768018,FALSE
+"H1648","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24207,0.733,0.838,4853,1,"NFKBIA, IRAK2, IKBKB, NTF4, PLCG2, FOXO3, BRAF, NFKBIE, PIK3CB, MAPK9, MAPK13, CALML6, RPS6KA4, MAP2K1, IRAK1, PRDM4, MAPK10, BAD, NGFR, SH2B2, CSK, NFKB1, CALML5, PSEN1, MAP3K5, RIPK2, PIK3CA, ZNF274, SORT1, RAC1, RELA, IRS1, PRKCD, MAPK12, IRAK3, CAMK2G, YWHAZ",0.0767559813697235,0,FALSE
+"H1648","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.32396,0.971,0.483,4624,0.941,"NADK, NAMPT, NADSYN1, NMNAT3, PNP, NT5C1B, NT5C2, QPRT, NT5E",0.316052869248488,0.0264103765727431,FALSE
+"H1648","Input","KEGG_NITROGEN_METABOLISM",0.28304,0.848,0.694,4648,1,"CA13, CA7, GLUD1, GLUL, HAL, GLS2",0.158640529545145,0,FALSE
+"H1648","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.48837,1.48,0.0682,3916,0.553,"CCL5, NFKBIA, BIRC3, CXCL1, TNFAIP3, CXCL2, IKBKB, CXCL8, TAB2, MAPK9, MAPK13, IL6, PSTPIP1, IL18, CARD6, MAPK10, NOD2, TNF, NFKB1, NLRP1, TAB3, RIPK2, NOD1, CARD9",1.16621562534352,0.257274868695302,FALSE
+"H1648","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.3414,-1.23,0.175,15827,0.808,"XRCC6, XRCC4, NHEJ1, RAD50, XRCC5",0.756961951313706,0.0925886392254138,FALSE
+"H1648","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26511,0.801,0.763,5702,1,"E2F1, PLCG2, FOXO3, EGF, BRAF, PIK3CB, TGFA, MAP2K1, BAD, RXRA, PIK3CA, RASSF5, CDK6, EGFR, RAF1, CCND1, ERBB2, MAP2K2",0.11747546204512,0,FALSE
+"H1648","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.51853,1.57,0.0287,2688,0.686,"DVL1, DVL3, DTX4, RFNG, DTX3L, JAG1, ADAM17, DLL1, HES1, HES5, NOTCH3, DTX2, JAG2, KAT2A, HDAC2",1.54211810326601,0.163675884293248,FALSE
+"H1648","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.38986,-1.39,0.123,15123,0.636,"RFC1, XPA, GTF2H1, ERCC4, RAD23B, GTF2H4, RPA1, RFC2, ERCC1, RAD23A, ERCC6, ERCC2, ERCC8, CCNH, RBX1, XPC, CUL4A, RPA2",0.910094888560602,0.196542884351586,FALSE
+"H1648","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.26447,0.798,0.776,4552,1,"ALG3, MGAT4B, RFT1, RPN2, RPN1, MGAT1, ALG10, ALG10B, FUT8, MAN2A2, MOGS, DPAGT1, MGAT2, TUSC3, ALG8",0.110138278741812,0,FALSE
+"H1648","Input","KEGG_OLFACTORY_TRANSDUCTION",0.38106,1.15,0.252,1976,0.673,"OR4C6, OR2J3, OR5M11, OR8S1, OR6B2, OR13D1, OR1J1, OR4D2, OR13H1, OR10AD1, OR2A5, OR4L1, OR2D2, OR11H4, OR10K2, OR2A7, OR4X2, OR1G1, OR10H1, OR8G1, OR2A12, OR8B4, GUCY2D, CALML6, OR8G5, OR6A2, OR10G3, OR8B8, OR4K1",0.598599459218456,0.171984935776023,FALSE
+"H1648","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.22828,-0.853,0.612,14026,0.88,"ATIC, DHFR, FTCD, TYMS, MTHFD2, MTR",0.213248577854439,0.0555173278498314,FALSE
+"H1648","Input","KEGG_OOCYTE_MEIOSIS",-0.31904,-1.19,0.207,16772,0.78,"CPEB1, MAD2L2, CDC23, CALM1, PRKACA, SMC3, YWHAE, ADCY9, FBXO43, PRKACB, ITPR2, RPS6KA2, RPS6KA1, SMC1A, SKP1, PPP2R1A, RBX1, CALM3, SGO1, ANAPC13, PPP3CB, PPP2R5C, CDC25C, PPP2R5D, CDC16, PPP3R1, ANAPC10",0.684029654543082,0.10790539730952,FALSE
+"H1648","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.49486,1.47,0.0576,6273,0.543,"MANBA, ENGASE, MAN2C1, FUCA2, HEXA, MAN2B1, MAN2B2, FUCA1, NEU1",1.23957751657679,0.265200170411153,FALSE
+"H1648","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.23704,-0.845,0.626,18279,0.874,"NDUFA8, NDUFA7, NDUFA4, NDUFS4, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, ATP5ME, COX6B1, NDUFB2, ATP6V1E1, SDHC, ATP5MC2, NDUFS5",0.20342566678957,0.058488567365597,FALSE
+"H1648","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.51195,1.53,0.0378,3145,0.458,"ST6GALNAC1, GCNT3, B4GALT5, GALNT7, GALNT5, GALNT12, GALNT10, GALNT3, GALNT6, GALNT18, GALNT14",1.42250820016277,0.339134521996131,FALSE
+"H1648","Input","KEGG_P53_SIGNALING_PATHWAY",0.24741,0.736,0.854,6303,1,"ATR, GADD45A, SERPINB5, CD82, PERP, TP53I3, GADD45B, PMAIP1, SFN, EI24, RPRM, THBS1, CCND3, CYCS, TNFRSF10B, GADD45G, CDK6, IGFBP3, STEAP3, CCND1, BID, TP73, PIDD1, CHEK1, TSC2, CDKN1A, FAS",0.068542129310995,0,FALSE
+"H1648","Input","KEGG_PANCREATIC_CANCER",0.29184,0.89,0.619,5629,1,"IKBKB, E2F1, SMAD3, EGF, VEGFC, BRAF, PIK3CB, MAPK9, RAD51, RAC2, TGFA, MAP2K1, MAPK10, BAD, TGFB3, NFKB1, PIK3CA, RALB, TGFBR2, IKBKG, RALGDS, RAC1, RELA, TGFB2, CDK6, EGFR, BRCA2, RAF1, PLD1, BCL2L1, TGFB1, CCND1, ERBB2",0.208309350979882,0,FALSE
+"H1648","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.22684,0.68,0.913,5025,1,"PPCDC, COASY, PANK4, PANK3, PANK2",0.039529222465701,0,FALSE
+"H1648","Input","KEGG_PARKINSONS_DISEASE",-0.26648,-0.963,0.477,18279,0.801,"NDUFA8, PINK1, NDUFA7, NDUFA4, NDUFS4, NDUFS7, ATP5F1A, COX7B, UQCR10, NDUFB1, APAF1, COX6B1, NDUFB2, SDHC, PARK7, ATP5MC2, NDUFS5",0.321481620959886,0.0963674839157623,FALSE
+"H1648","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.31553,-1.14,0.221,16110,0.593,"TUBA3D, ROCK1, YWHAQ, TUBB4A, CD14, ACTB, TUBA1B, ARHGEF2, TUBA8, RHOA, TUBB2A, ABL1, TLR4, TUBB3, FYN, TUBB, ARPC5, TUBA1A, CDC42",0.655607726314889,0.226945306635737,FALSE
+"H1648","Input","KEGG_PATHWAYS_IN_CANCER",0.28487,0.85,0.661,3822,1,"MMP9, WNT9A, NFKBIA, DVL1, BIRC3, FGF17, IKBKB, TRAF4, DVL3, NFKB2, MET, FGFR3, E2F1, BCR, CXCL8, LAMC2, SMAD3, LAMA3, WNT7A, ITGA2, PLCG2, FGF11, FGF13, LAMB3, MMP1, PML, CDH1, EGLN3, EGF, VEGFC, WNT10A, JUP, BRAF, PIK3CB, MAPK9, CSF2RA, FOXO1, RUNX1, RAD51, RAC2, TRAF1, IL6, BMP2, CBLC, TGFA, PAX8, MAP2K1, TRAF2, VHL, LAMA2, FZD5, IGF1R, MAPK10, HDAC2, MECOM, PDGFB, BAD, ITGAV, PDGFA, PTK2, TGFB3, NFKB1, CSF1R, FZD6, LAMA5, RXRA, PIK3CA, MYC, MTOR, ELOC, TFG, RALB, TGFBR2, WNT3, FGFR2",0.17979854051436,0,FALSE
+"H1648","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.26823,0.805,0.751,2843,1,"UGDH, RPEL1, GUSB",0.124360062995832,0,FALSE
+"H1648","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.50757,1.53,0.038,5444,0.458,"G6PD, PGD, TKT, TALDO1, RPEL1, PFKL, FBP2, ALDOC, DERA, GPI, ALDOA, PGM2, PFKP",1.42021640338319,0.339134521996131,FALSE
+"H1648","Input","KEGG_PEROXISOME",0.23246,0.7,0.895,5121,1,"XDH, SOD2, ACSL5, PRDX5, PEX2, SLC27A2, PEX5, PRDX1, DDO, ACAA1, MVK, PAOX, ABCD1, GSTK1, EPHX2, PEX3, MLYCD, EHHADH, AGPS, DHRS4, SOD1, PEX7, PEX16, NUDT19, ACOT8, ACOX1",0.048176964684088,0,FALSE
+"H1648","Input","KEGG_PHENYLALANINE_METABOLISM",0.55315,1.65,0.0232,4365,0.771,"IL4I1, ALDH3A1, AOC2, ALDH1A3, ALDH3B2, MAOA, AOC3",1.6345120151091,0.112945621949043,FALSE
+"H1648","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25378,0.755,0.822,3949,1,"INPP4A, PLCG2, PIK3CB, INPP4B, CALML6, PLCB3, DGKQ, DGKA, SYNJ2, PIK3C2B, CALML5, DGKG, DGKE, IPPK, PIK3C2G, PIK3CA, CDS1, ITPR3, OCRL",0.0851281824599496,0,FALSE
+"H1648","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.34428,1.03,0.396,3373,0.875,"CP, EARS2, FTH1, GUSB, ALAS1, HMOX2",0.402304814074488,0.0579919469776868,FALSE
+"H1648","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.18465,0.555,0.987,5588,1,"FABP6, MMP1, ACSL5, SLC27A4, ME1, SLC27A2, ACAA1, RXRA, CPT2, UBC, CYP27A1, EHHADH, ANGPTL4, CPT1C, ACOX1, CPT1A, ACSL1, SLC27A1, PPARG",0.00568284733036327,0,FALSE
+"H1648","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.28189,0.849,0.718,4036,1,"CH25H, CYP7B1, AKR1D1, CYP27A1",0.1438755557577,0,FALSE
+"H1648","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.38015,1.13,0.272,5251,0.703,"CD40, CIITA, ADA, TAP2, LCK, BLNK, IKBKG, JAK3, RAG2, UNG, TAP1",0.565431095965801,0.153044674980176,FALSE
+"H1648","Input","KEGG_PRION_DISEASES",0.30397,0.926,0.578,2350,1,"CCL5, C9, IL1A, IL6, MAP2K1",0.238072161579471,0,FALSE
+"H1648","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28281,-1.02,0.415,16258,0.753,"CDK1, PDE3A, ARAF, CPEB1, MAD2L2, CDC23, CDC25B, PRKACA, ADCY9, PRKACB, RPS6KA2, RPS6KA1, PDE3B, PIK3R1, AKT3, MAPK14, GNAI1, ANAPC13, CDC25C, CDC16, MAPK8, ANAPC10",0.381951903287907,0.123205023799299,FALSE
+"H1648","Input","KEGG_PROPANOATE_METABOLISM",-0.28276,-1.06,0.344,14863,0.718,"ABAT, PCCA, SUCLA2, SUCLG1, ACSS1, LDHC, ACACB, HIBCH, ACADM, ALDH1B1, ALDH9A1",0.46344155742847,0.1438755557577,FALSE
+"H1648","Input","KEGG_PROSTATE_CANCER",0.23981,0.722,0.875,5702,1,"NFKBIA, IKBKB, E2F1, EGF, BRAF, PIK3CB, FOXO1, TGFA, MAP2K1, IGF1R, PDGFB, BAD, PDGFA, NFKB1, CREB3, PIK3CA, MTOR, FGFR2, IKBKG, RELA, CREB5, EGFR, GSTP1, RAF1, TCF7, CCND1, ERBB2, MAP2K2",0.0579919469776868,0,FALSE
+"H1648","Input","KEGG_PROTEASOME",0.27494,0.827,0.717,3211,1,"PSME4, PSME2, PSMB11, PSME1, PSMD11, PSMF1, PSMA5, PSMD2, PSMB5, PSMB10, PSMA6",0.1444808443322,0,FALSE
+"H1648","Input","KEGG_PROTEIN_EXPORT",0.271,0.811,0.745,4969,1,"OXA1L, SRPRA, SEC63, SRP54, SRPRB, SEC11A, SEC62, SRP68, SEC61A1",0.127843727251707,0,FALSE
+"H1648","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.16518,0.496,0.995,5399,0.996,"SLC25A10, GLUD1, ATP1B3, GLS2, ATP1A3, ATP1B1",0.00217691925427455,0.00174066157630127,FALSE
+"H1648","Input","KEGG_PURINE_METABOLISM",-0.19398,-0.667,0.908,16712,0.932,"POLR2D, NME7, NPR2, RRM2B, PDE1C, PDE7B, POLA1, PDE6B, PDE6G, POLR2G, PAPSS1, ADSL, ADCY9, PDE10A, PDE8B, PDE6D, APRT, PRUNE1, AK5, PDE3B, PDE4B, PRIM2, AK7, ENPP1, PAPSS2, NT5M, DCK, POLR3GL, DGUOK, POLR1E",0.0419141514789149,0.0305840876460186,FALSE
+"H1648","Input","KEGG_PYRIMIDINE_METABOLISM",0.21269,0.644,0.951,5377,1,"ENTPD3, POLR2H, UMPS, CMPK2, TXNRD1, POLR1B, PNP, UPP1, NME6, NT5C1B, POLD4, ENTPD4, UCKL1, PNPT1, DUT, NT5C2, TYMP, CDA, POLE2, POLR1C, NT5E, CAD, CMPK1, POLA2, NT5C, POLE, ENTPD5, NME5",0.0218194830625861,0,FALSE
+"H1648","Input","KEGG_PYRUVATE_METABOLISM",-0.23207,-0.841,0.705,18284,0.835,"MDH1, ALDH1B1, ALDH9A1, GRHPR",0.151810883008601,0.0783135245163979,FALSE
+"H1648","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.25971,0.782,0.794,3219,1,"ITGAM, FGF17, PFN4, DIAPH1, ITGB6, ARHGEF4, FGFR3, TMSB4Y, ITGA2, FGF11, FGF13, ITGB2, PAK6, EGF, BRAF, PIK3CB, BAIAP2, ITGB4, ITGB8, SSH3, MYH14, PAK2, RAC2, CHRM3, SSH1, MAP2K1, VAV1, FGD3, EZR, PAK1, ITGAX, PDGFB, ITGAV, TIAM1, LIMK2, PDGFA, PTK2, CSK, GIT1",0.100179497572904,0,FALSE
+"H1648","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.24812,0.74,0.85,1482,1,"ULK1, ATG5, PIK3R4, BECN1",0.0705810742857073,0,FALSE
+"H1648","Input","KEGG_RENAL_CELL_CARCINOMA",0.22262,0.671,0.926,5045,1,"MET, PAK6, EGLN3, VEGFC, BRAF, PIK3CB, PAK2, TGFA, MAP2K1, VHL, PAK1, PDGFB, TGFB3, PIK3CA, ELOC, HIF1A, RAC1, TGFB2, ETS1, RAF1",0.0333890133180656,0,FALSE
+"H1648","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.25357,0.76,0.826,5920,1,"ACE, CTSA, REN, THOP1, ACE2",0.0830199526796178,0,FALSE
+"H1648","Input","KEGG_RETINOL_METABOLISM",0.46555,1.4,0.0891,5135,0.474,"RDH16, ADH7, CYP1A1, DHRS9, DGAT1, RDH10, CYP26A1, CYP2C18, DHRS3, DGAT2, ALDH1A2, CYP26B1, LRAT, DHRS4, BCO1, ADH1A, DHRS4L2, ALDH1A1, RDH11",1.05012229596313,0.324221658325915,FALSE
+"H1648","Input","KEGG_RIBOFLAVIN_METABOLISM",0.24282,0.72,0.882,5743,1,"MTMR1, ACP6, ACP4, ACP5, ACP1, FLAD1",0.0545314148681803,0,FALSE
+"H1648","Input","KEGG_RIBOSOME",-0.51374,-1.8,0,16296,0.3,"RPL9, RPL26, RPL24, RPS4X, RPL10A, RPL3, RPS24, RPS18, RPS13, RPS15, RPL7A, RPL34, UBA52, RPL21, RPL13A, RPS23, RPL27A, RPL6, RPL29, RPL5, RPL11, RPSA, RPL37A, RPL18, RPL35, RPS19, RPS16, RSL24D1, RPS9, RPS5, RPS11, RPS6, RPS27L, RPS10, RPS15A, RPS27, RPL17",Inf,0.522878745280338,FALSE
+"H1648","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.46961,1.41,0.0796,3125,0.494,"CXCL10, IFNB1, NFKBIA, DDX58, IKBKE, IKBKB, CXCL8, ATG5, DDX3Y, TRADD, ISG15, DHX58, IRF7, MAPK9, MAPK13, IRF3, IFIH1, TRAF2, MAPK10, TNF, NFKB1",1.09908693226233,0.306273051076353,FALSE
+"H1648","Input","KEGG_RNA_DEGRADATION",-0.35043,-1.31,0.101,17144,0.677,"PAPOLG, DCP2, PAPOLA, EXOSC8, MPHOSPH6, XRN2, LSM3, LSM7, TTC37, LSM2, ENO1, EXOSC3, C1D, ZCCHC7",0.995678626217357,0.169411331314856,FALSE
+"H1648","Input","KEGG_RNA_POLYMERASE",-0.25521,-0.926,0.528,14661,0.808,"POLR2C, POLR2L, POLR2J3, POLR2I, POLR2F, POLR2D, POLR2G, POLR3GL, POLR1E",0.277366077466188,0.0925886392254138,FALSE
+"H1648","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.45765,1.38,0.104,4199,0.501,"LCMT1, AHCY, GGT6, GGT1, TRMT11, GGT7, AHCYL1, HEMK1, MAT2B",0.98296666070122,0.300162274132754,FALSE
+"H1648","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.30031,0.895,0.623,3622,1,"NFKBIA, BIRC3, IKBKB, TRAF4, E2F1, LAMC2, LAMA3, ITGA2, LAMB3, PIK3CB, TRAF1, TRAF2, LAMA2, ITGAV, PTK2, NFKB1, LAMA5, RXRA, PIK3CA, MYC",0.20551195334083,0,FALSE
+"H1648","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.25951,-0.905,0.537,17365,0.805,"USE1, STX8, SNAP25, VAMP5, STX2, SEC22B, VAMP3, STX12",0.270025714300444,0.0942041196321315,FALSE
+"H1648","Input","KEGG_SPHINGOLIPID_METABOLISM",0.32506,0.982,0.459,3712,0.946,"SMPD2, GLA, SGPP2, ACER3, DEGS2, PLPP3, PLPP2, SPHK1, UGT8, SGMS2",0.338187314462739,0.0241088635982073,FALSE
+"H1648","Input","KEGG_SPLICEOSOME",0.24679,0.737,0.853,1835,1,"LSM8, SRSF6, CTNNBL1, PRPF40B, SART1, SRSF5, THOC3, U2SURP, AQR, RBM22, ACIN1, PRPF38B, NCBP2, TCERG1, TRA2B, RBM25, ZMAT2, PRPF38A, SRSF2, ISY1",0.069050968832477,0,FALSE
+"H1648","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.20729,0.629,0.963,3831,1,"UGDH, PYGL, GANC, GUSB, UXS1, GAA, GPI",0.0163737128754655,0,FALSE
+"H1648","Input","KEGG_STEROID_BIOSYNTHESIS",-0.23238,-0.84,0.646,14250,0.814,"MSMO1, HSD17B7, SOAT1, CYP27B1, LSS, CYP51A1",0.189767482004916,0.0893755951107988,FALSE
+"H1648","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.47261,1.43,0.0603,4006,0.549,"AKR1C2, CYP1A1, AKR1C3, HSD17B3, AKR1C1, SRD5A1, CYP7B1, CYP1B1, AKR1D1, SRD5A3, HSD11B1, HSD11B2, HSD17B8, SULT2B1",1.21968268785985,0.260427655549908,FALSE
+"H1648","Input","KEGG_SULFUR_METABOLISM",0.4448,1.34,0.0918,4113,0.559,"SULT1A4, SULT1A1, CHST11, SULT1A2, SULT2B1, SUOX",1.03715731879876,0.252588192113577,FALSE
+"H1648","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.22043,0.666,0.936,2957,1,"C9, CD40, C3, TNF",0.0287241512618947,0,FALSE
+"H1648","Input","KEGG_TASTE_TRANSDUCTION",0.39248,1.18,0.215,5194,0.702,"SCNN1G, SCNN1B, TAS1R3, TAS2R31, SCNN1A, ADCY4, ADCY6, ITPR3, GNB1, TAS2R20, TAS2R4, TAS2R5, GNG3, TAS2R13, TAS2R19, TAS2R10",0.667561540084395,0.153662887870195,FALSE
+"H1648","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.63202,1.9,0.00342,3251,0.639,"GGT6, GGT1, GAD1, GGT7",2.46597389394387,0.1944991418416,FALSE
+"H1648","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.61874,-2.32,0,17922,0.0687,"HMGCR, IDI1, DHDDS, FDPS, GGPS1, PMVK",Inf,1.16304326294045,TRUE
+"H1648","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.28043,-0.965,0.444,16153,0.827,"ROCK1, SMAD5, BMP8A, THBS2, RBL2, BMP8B, NOG, ID4, BMPR1A, CHRD, BMP6, ACVR2A, DCN, RHOA, SMAD9, SKP1, PPP2R1A, CDKN2B, ZFYVE16, RBX1, TFDP1, TGFBR1, BMPR2, LTBP1, SMAD2",0.35261702988538,0.0824944904474534,FALSE
+"H1648","Input","KEGG_THYROID_CANCER",0.25693,0.77,0.818,5702,1,"CDH1, BRAF, PAX8, MAP2K1, RXRA, MYC, TFG, TCF7, PPARG, CCND1, CCDC6, MAP2K2",0.087246696328677,0,FALSE
+"H1648","Input","KEGG_TIGHT_JUNCTION",0.33873,1.02,0.392,2982,0.88,"CLDN18, SRC, CLDN9, CLDN10, CLDN8, CGN, PRKCH, CLDN20, HCLS1, PPP2R2C, TJP3, CLDN7, CLDN3, AFDN, MYH14, CLDN23, EPB41L1, CRB3, CLDN4, CLDN1, OCLN, TJP1, MYH7B, YBX3, LLGL2, F11R, PPP2R2A, PRKCZ",0.406713932979543,0.0555173278498314,FALSE
+"H1648","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.50914,1.55,0.0396,3623,0.534,"CXCL10, IFNB1, CXCL9, CXCL11, CCL5, NFKBIA, IRF5, TLR6, IKBKE, TLR1, TLR2, IKBKB, CXCL8, CD40, TAB2, IRF7, PIK3CB, MAPK9, MAPK13, CCL3, MAP3K8, IL6, TICAM1, IRF3, TLR5, MAP2K1, IRAK1, MAPK10, TNF, MYD88, NFKB1, TLR3, PIK3CA, IFNAR2",1.40230481407449,0.272458742971444,FALSE
+"H1648","Input","KEGG_TRYPTOPHAN_METABOLISM",0.3607,1.08,0.338,517,0.772,"KYNU, IL4I1, CYP1A1, IDO1, KMO",0.471083299722345,0.112382699664264,FALSE
+"H1648","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29189,0.868,0.659,5887,1,"IKBKB, PIK3CB, MAPK9, MAPK10, TNF, PRKCZ, PKM, PIK3CA, MTOR, SOCS2, INSR, IRS1, HK2, PRKCD, SOCS1, HK1, SOCS3, PRKCE",0.18111458540599,0,FALSE
+"H1648","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.25809,0.767,0.826,2957,1,"IL1A, GAD1, TNF",0.0830199526796178,0,FALSE
+"H1648","Input","KEGG_TYROSINE_METABOLISM",0.44025,1.33,0.116,4885,0.565,"LCMT1, ADH7, IL4I1, ALDH3A1, AOC2, ALDH1A3, TRMT11, ALDH3B2, HEMK1, MAOA, AOC3, FAH, ADH1A",0.935542010773082,0.247951552180562,FALSE
+"H1648","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3545,1.06,0.378,4757,0.821,"NFKBIA, CSF2, CARD11, IKBKB, NCK1, DLG1, NFATC4, PAK6, RASGRP1, NFKBIE, PIK3CB, MAPK9, MAPK13, PAK2, MAP3K8, PTPN6, CHP2, CBLC, MAP2K1, VAV1, PAK1, MAP3K14, TNF, NFKB1, TEC, LCK, PIK3CA, BCL10, IKBKG, LAT, NFATC2, VAV3, RELA, NFAT5, MAPK12",0.422508200162775,0.0856568428805592,FALSE
+"H1648","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.19754,0.594,0.975,6114,1,"ITCH, BIRC3, UBE2J2, SMURF1, UBR5, PML, FBXO2, SYVN1, UBE2G2, UBE3C, CBLC, FBXW11, VHL, ANAPC7, UBE2L6, UBE2Z, UBE2K, ANAPC5, BRCA1, UBE2H, RNF7, BIRC6, HERC2, ANAPC4, ELOC, WWP1, UBA7, UBE2W, UBE2O, FZR1, ANAPC2, UBE4A, DDB1, UBE3B, SOCS1, UBA6, MAP3K1, ANAPC1, CDC34, HERC1, SOCS3, RHOBTB2, KEAP1, UBE3A, KLHL13, PIAS1, UBE2C, UBE2A, XIAP",0.0109953843014632,0,FALSE
+"H1648","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.48196,-1.79,0.0242,14636,0.234,"BCAT2, VARS2, IARS2, PDHB",1.61618463401957,0.630784142589857,TRUE
+"H1648","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.26043,-0.941,0.511,14302,0.798,"HMGCS2, HADHB, BCAT2, ACADSB, ABAT, OXCT1, PCCA, HMGCL, HSD17B10, BCKDHB, HIBADH, AOX1, HADH, HIBCH, ACADM, ALDH1B1, ACAA2, ALDH9A1",0.291579099865287,0.0979971086492706,FALSE
+"H1648","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.17472,0.528,0.994,3255,0.999,"PLA2G4E, KCNMB3, PRKCH, ADRA1B, BRAF, CALML6, ADCY4, PLA2G4B, PLCB3, PLA2G10, MAP2K1, ADORA2A, ADCY6, CACNA1F, ADCY3, CALML5",0.00261361560268669,0.000434511774017692,FALSE
+"H1648","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.3318,-1.17,0.268,15891,0.632,"AVPR2, DCTN4, DYNC1LI1, RAB5B, PRKACA, DCTN2, ADCY9, PRKACB, CREB3L1, ARHGDIA, DYNLL1, CREB3L2, DCTN6, DYNC1I2, DCTN1",0.571865205971211,0.199282921717615,FALSE
+"H1648","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.31218,0.931,0.553,5910,1,"SRC, PLA2G4E, PLCG2, NFATC4, PIK3CB, MAPK13, RAC2, PLA2G4B, CHP2, PLA2G10, MAP2K1, NOS3, MAPKAPK3, BAD, PTK2, SPHK1, PIK3CA, PXN, PLA2G12A, NFATC2, PLA2G2F, RAC1, NFAT5, MAPK12, RAF1, PTGS2, CHP1, MAPK11, MAP2K2, SHC2, PLA2G6",0.257274868695302,0,FALSE
+"H1648","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.36553,1.1,0.306,4492,0.739,"ATP6V0D2, ATP6V1C2, KCNQ1, ERO1A, PLCG2, TCIRG1, ATP6V0E1, TJP1, ATP6V0A2, ATP6V0B, ATP6V1H, ADCY3, ATP6V0E2, SLC12A2, ATP6V1C1, ATP6V1A, TJP2",0.51427857351842,0.131355561605174,FALSE
+"H1648","Input","KEGG_VIRAL_MYOCARDITIS",0.20176,0.598,0.968,4621,1,"EIF4G1, CD40, ITGB2, MYH14, RAC2, MYH7B, LAMA2, MYH11, CXADR, CYCS, CAV1, RAC1",0.0141246426916063,0,FALSE
+"H1648","Input","KEGG_WNT_SIGNALING_PATHWAY",0.25713,0.774,0.824,4389,1,"MMP7, TBL1Y, WNT9A, DVL1, DVL3, CHD8, CSNK1A1, SENP2, PORCN, TBL1XR1, SMAD3, WNT7A, NKD2, NFATC4, WNT10A, MAPK9, CTNNBIP1, RAC2, CHP2, PLCB3, FBXW11, FZD5, RUVBL1, MAPK10, CSNK1E, FRAT2, SFRP5, FZD6, PSEN1, CSNK1A1L, MYC, WNT3, VANGL1, CCND3, VANGL2, LRP5, WNT7B, NFATC2",0.0840727883028842,0,FALSE
+"H2126","Input","KEGG_ABC_TRANSPORTERS",0.36567,1.08,0.328,3789,0.95,"ABCG2, ABCG1, ABCC2, ABCC3, ABCD1, ABCB8, ABCD4, ABCB7, ABCA12, ABCB6",0.484126156288321,0.0222763947111523,FALSE
+"H2126","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.22193,-0.792,0.79,15187,0.873,"PIK3CD, MAP2K1, PPARD, CEBPA, EIF4EBP1, CCNA1, LEF1, PIK3R1, RAF1, PIM1, PIM2, TCF7, BAD, HRAS, PML, NRAS, AKT3",0.102372908709559,0.0589857562944303,FALSE
+"H2126","Input","KEGG_ADHERENS_JUNCTION",-0.23621,-0.854,0.654,17317,0.825,"SNAI2, VCL, CDC42, RHOA, TCF7, ACTN1, ACTG1, CSNK2B, FER, NECTIN3, ACTB, FYN, WASF1",0.184422251675733,0.0835460514500749,FALSE
+"H2126","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.42392,1.24,0.161,4364,0.769,"PRKAB1, IRS2, CPT1B, PRKAG1, TRAF2, STAT3, ADIPOR1, PRKAA2, ACSL1, PPARA, ACSL3, IKBKB, RELA, CAMKK2, RXRA, ACACB, TRADD, AKT1, PRKAB2, IKBKG, PRKAA1, CPT1C, TNFRSF1B, MTOR, TNFRSF1A",0.79317412396815,0.114073660198569,FALSE
+"H2126","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.37403,1.09,0.313,4731,0.932,"AGXT, GPT, GLUL, GFPT1, CPS1, ALDH5A1, CAD, GLS2, ALDH4A1",0.504455662453552,0.0305840876460186,FALSE
+"H2126","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.30824,0.914,0.592,4356,1,"IRS2, INS, SCNN1A, FXYD4, PIK3R3, ATP1B1, MAPK3, PRKCG, KCNJ1, MAPK1",0.22767829327708,0,FALSE
+"H2126","Input","KEGG_ALLOGRAFT_REJECTION",-0.32815,-1.15,0.221,10722,0.638,"CD28, CD40LG, IL2, FASLG, IL12B, CD80, IL4, IL10, PRF1, CD86, TNF, GZMB, FAS, IL12A",0.655607726314889,0.195179321278838,FALSE
+"H2126","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.52753,1.57,0.0325,4629,0.481,"PLA2G6, PLA2G12A, PLA2G10, ACOX3, PLA2G2D, PLA2G2C, PLA2G4A, PLA2G4B",1.48811663902113,0.317854923626168,FALSE
+"H2126","Input","KEGG_ALZHEIMERS_DISEASE",0.18914,0.553,0.989,4587,1,"CASP9, ATP2A3, UQCR11, GRIN2D, EIF2AK3, GRIN1, CALML6, ITPR1, CACNA1D, NDUFV2, APH1A, NDUFA3, PSEN1, ERN1, APAF1, NDUFV1, IDE, COX6A1, NDUFA10, ATP5MC2, MAPK3, NDUFB1, ADAM10, NDUFA5, PLCB1, SDHA, UQCRHL, PSENEN, BID, MAPK1, TNFRSF1A, COX6A2, CACNA1F, GNAQ, SDHD",0.0048037084028206,0,FALSE
+"H2126","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29099,-1.02,0.375,16444,0.684,"WARS2, FARSB, LARS2, CARS2, RARS2, YARS2, PSTK",0.425968732272281,0.164943898279884,FALSE
+"H2126","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.58332,1.71,0.0171,5813,0.723,"NANS, GMPPA, HK2, FPGT, GNPDA2, UGDH, GNPNAT1, GFPT1, GALK2, NANP, GMDS, PGM1, GNE, NPL, GMPPB, PGM3, PMM2, MPI, PGM2, CHIT1, HEXB, UGP2, GALT, GALE",1.76700388960785,0.140861702705469,FALSE
+"H2126","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.21727,0.624,0.949,4364,1,"CASP9, GRIN2D, GRIN1, SLC1A2, MAP3K5, CCS, APAF1, BAX, MAPK13, DERL1, TNFRSF1B, BID, TNFRSF1A",0.0227337875727074,0,FALSE
+"H2126","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.30656,0.911,0.594,4038,1,"CTSL, HSPA1L, CD4, LGMN, NFYC, TAPBP, IFI30, HSPA1A, CREB1, HSPA1B, HSPA2, KLRC3, PDIA3",0.226213555018806,0,FALSE
+"H2126","Input","KEGG_APOPTOSIS",0.25302,0.74,0.865,4364,1,"CASP9, IRAK4, ATM, TRAF2, XIAP, IKBKB, AIFM1, RELA, CSF2RB, TRADD, PIK3R3, APAF1, BAX, AKT1, BIRC3, MYD88, IL1R1, IKBKG, BIRC2, BID, TNFRSF1A",0.0629838925351858,0,FALSE
+"H2126","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.43071,1.27,0.156,3980,0.743,"CYP4A22, PTGES, PLA2G6, ALOX15B, PLA2G12A, CYP4F3, CYP2J2, PLA2G10, PTGES2, LTA4H, PTGDS, ALOX5, PLA2G2D, PTGS1, GPX2, EPHX2, ALOX12B, PLA2G2C, LTC4S, PLA2G4A, GPX3",0.806875401645538,0.129011186239425,FALSE
+"H2126","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.2584,0.759,0.81,6291,1,"GLUL, SAT1, PYCR1, ALDH18A1, GATM, CKMT1A, CKMT1B, ALDH2, CPS1, ALDH3A2, P4HA3, ARG1, GLS2, AGMAT, MAOA, ALDH4A1, GAMT, ASS1, P4HA2, ASL, PYCR3, ODC1",0.0915149811213502,0,FALSE
+"H2126","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.18921,0.545,0.985,4525,1,"CACNB2, CACNG1, CACNA1D, ITGB6, ITGB5, ITGA1, CACNG6, ITGA2B, JUP, DMD, ITGB1, DSP, CACNG8, CACNG4, CACNA1F",0.00656376950238827,0,FALSE
+"H2126","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.25981,0.764,0.831,3745,1,"UGDH, ALDH2, ALDH3A2",0.080398976215889,0,FALSE
+"H2126","Input","KEGG_ASTHMA",0.25981,0.755,0.819,14150,1,"CD40, EPX, IL5, IL13, IL9, MS4A2, FCER1A, FCER1G, CD40LG, IL3, CCL11, PRG2, IL4, IL10, TNF, RNASE3",0.0867160982395816,0,FALSE
+"H2126","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.27766,0.814,0.76,170,1,"CGA",0.119186407719209,0,FALSE
+"H2126","Input","KEGG_AXON_GUIDANCE",0.21615,0.635,0.962,3790,1,"FES, RND1, SEMA4C, EFNA1, SRGAP1, EPHA1, SEMA3E, EFNA3, SEMA4B, NTN4, PLXNB2, PLXNA3, SEMA3B, PAK4, PAK6, EPHB6, EFNA4, RHOD, MAPK3, SRGAP3, EFNA5, ARHGEF12, ROCK1, ITGB1, SEMA4G",0.0168249279621871,0,FALSE
+"H2126","Input","KEGG_BASAL_CELL_CARCINOMA",0.36601,1.07,0.345,1246,0.967,"WNT3A, FZD10, WNT4, WNT7B, WNT11",0.462180904926726,0.0145735259169983,FALSE
+"H2126","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.3626,-1.3,0.134,17299,0.683,"GTF2H1, STON1, TAF9, GTF2E2, GTF2H3, TAF5, TAF7, GTF2B, TBPL1",0.872895201635192,0.165579296318467,FALSE
+"H2126","Input","KEGG_BASE_EXCISION_REPAIR",0.27861,0.811,0.755,1281,1,"LIG3, SMUG1, NEIL1, MUTYH",0.122053048370812,0,FALSE
+"H2126","Input","KEGG_BETA_ALANINE_METABOLISM",0.28488,0.843,0.696,3745,1,"AOC2, ACADM, AOC3, ALDH2, ALDH3A2",0.157390760389438,0,FALSE
+"H2126","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.27539,0.801,0.757,2367,1,"ACOT4, ACOX3, ACOT1, ACOT2",0.120904120499927,0,FALSE
+"H2126","Input","KEGG_BLADDER_CANCER",-0.31965,-1.19,0.2,15388,0.66,"MAP2K1, EGF, PGF, RASSF1, CXCL8, THBS1, CDKN1A, MMP1, RAF1, E2F2, E2F3, MMP2, TP53, CDKN2A, VEGFB, HRAS, NRAS, CDK4",0.698970004336019,0.180456064458131,FALSE
+"H2126","Input","KEGG_BUTANOATE_METABOLISM",-0.27931,-0.949,0.442,16610,0.677,"PDHB, ACSM3, ALDH1B1, ECHS1, ACAT1, ALDH9A1, BDH2, OXCT1",0.354577730650908,0.169411331314856,FALSE
+"H2126","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.23363,0.689,0.885,4005,1,"BLNK, VAV1, IKBKB, RELA, SOS2, CD72, PTPN6, PLCG2, PIK3R3, RASGRP3, AKT1, CD22, VAV2, MAPK3, CD19, IKBKG, SOS1",0.0530567293021746,0,FALSE
+"H2126","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.32819,0.968,0.486,3057,1,"BDKRB2, CD38, ATP2A3, BDKRB1, CACNA1I, ADCY4, PHKA1, P2RX4, GRIN2D, RYR1, GRIN1, CALML6, ITPR1, ADRA1D, ATP2B1, SLC8A2, CACNA1D, PTAFR, P2RX2, ERBB2, GNA14, PHKA2, CAMK2G, LTB4R2, PLCG2, TACR3, TRHR, ERBB3, CACNA1A",0.313363730737707,0,FALSE
+"H2126","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.27836,0.826,0.724,1492,1,"CACNB2, CACNG1, TNNI3, UQCR11, CACNA1D, SLC9A1",0.140261433802853,0,FALSE
+"H2126","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.24197,0.716,0.87,3758,1,"CDH5, ITGB2, ICAM3, CD4, PTPRF, CNTN1, ICOSLG, CDH3, NRXN3, CLDN3, ITGAL, CLDN20, CLDN7, CDH1, CD40, F11R, CD22, CLDN4, PTPRM, OCLN, ITGB1",0.0604807473813815,0,FALSE
+"H2126","Input","KEGG_CELL_CYCLE",-0.46269,-1.66,0.0484,16390,0.557,"GSK3B, MAD2L2, TTK, CCNA1, TFDP1, PTTG2, YWHAE, CCNE2, CDC20, MAD1L1, MCM5, CDKN1A, CDC25C, E2F2, MCM3, ANAPC13, TFDP2, E2F3, MCM2, RBL1, PRKDC, SKP1, PKMYT1, CCNH, MCM6, CDKN2B, TP53, CDK6, MAD2L1, CDKN2D, BUB1, CDKN2A, YWHAQ, CDC14A, GADD45A, CCNB2, CDKN1C, CDKN2C, PLK1, HDAC2, CDK1, CCNA2, CDC25A, MCM4, CDC7, ORC3, HDAC1, ORC6, BUB3, PTTG1, CDK4, CCNB1, SMC3, TGFB1",1.31515463835559,0.254144804826271,FALSE
+"H2126","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.24171,0.709,0.893,4024,1,"CCL22, ADCY5, CCR7, CCL17, ADCY4, ARRB1, VAV1, JAK3, STAT3, CCR3, ARRB2, IKBKB, RELA, CXCL16, WASL, GRK2, SOS2, ADCY6, PIK3R3, STAT2, AKT1, CXCL3, VAV2, MAPK3, PREX1, STAT5B, CXCL2, PRKCD, ROCK1, IKBKG, CCL28, SOS1, TIAM1",0.0491485411114536,0,FALSE
+"H2126","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.32338,-1.12,0.273,16866,0.571,"CDKN1A, PIK3R1, RAF1, E2F2, SHC2, E2F3, TP53, CDK6, CDKN2A, MECOM, BAD, HDAC2, HRAS, NRAS, AKT3, HDAC1, CDK4, TGFB1",0.563837352959244,0.243363891754152,FALSE
+"H2126","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.57486,1.69,0.0161,5204,0.612,"CSNK1E, PER2, CSNK1D, NPAS2, CLOCK, CRY1, BHLHE40, BHLHE41",1.79317412396815,0.213248577854439,FALSE
+"H2126","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.28756,0.841,0.705,4824,1,"SUCLG2, IDH3G, PC, IDH2, IDH3B, DLAT, SDHA, DLST, ACO2, SDHD, MDH2, PDHA1, IDH1",0.151810883008601,0,FALSE
+"H2126","Input","KEGG_COLORECTAL_CANCER",-0.27994,-1.03,0.346,15119,0.689,"RAC1, PIK3CD, MSH6, MAP2K1, MLH1, SMAD3, TGFB3, GSK3B, LEF1, MAPK10, BIRC5, PIK3R1, RAF1, RHOA, TP53, BCL2, JUN, TCF7, BAD, AKT3, TGFB1",0.460923901207223,0.161780778092374,FALSE
+"H2126","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.45314,1.33,0.0974,1849,0.789,"FGA, BDKRB2, FGG, FGB, BDKRB1, CD55, C8G, PLG, TFPI",1.01144104312138,0.10292299679058,FALSE
+"H2126","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.259,0.758,0.85,1369,1,"LDHC, TAT, CTH, AHCYL1",0.0705810742857073,0,FALSE
+"H2126","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.19403,0.579,0.979,4429,1,"CCL22, CCR7, CCL17, INHBB, EPO, TNFSF11, IFNL3, IL9R, TNFRSF18, IL13RA1, TGFBR1, CCR3, BMP7, CXCL16, CSF2RB, GH2, PDGFB, CD40, TNFRSF25, TNFSF13, TNFSF15, CLCF1, EPOR, CXCL3, LTBR, KITLG, VEGFC, CXCL2, OSMR, IL20RA, IL1R1, CCL28, TNFRSF1B, VEGFA, TNFRSF1A, VEGFD, IFNL2, TPO",0.00921730819686218,0,FALSE
+"H2126","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.2581,0.764,0.826,4933,1,"RIPK3, IRF3, IKBKB, RELA, ADAR, POLR3F, POLR3GL, TBK1, IKBKG, MAVS, CCL5, NFKBIB",0.0830199526796178,0,FALSE
+"H2126","Input","KEGG_DILATED_CARDIOMYOPATHY",0.273,0.806,0.757,2736,1,"ADCY5, CACNB2, CACNG1, TNNI3, ADCY4, CACNA1D, ITGB6, ITGB5, ITGA1, ADCY6, CACNG6, ITGA2B",0.120904120499927,0,FALSE
+"H2126","Input","KEGG_DNA_REPLICATION",-0.6495,-2.36,0.0087,16205,0.0748,"POLE3, PCNA, RPA2, POLE, RFC1, MCM5, PRIM1, POLA2, POLA1, MCM3, RPA3, RNASEH2C, RFC5, MCM2, MCM6, RFC4, RFC2, FEN1, MCM4, PRIM2",2.06048074738138,1.12609840213554,TRUE
+"H2126","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43235,1.27,0.142,4847,0.743,"PIWIL2, ETS2, SPIRE2, NOTCH3, SOS2, MAPK3, SOS1, MAPK1, ETV7",0.847711655616944,0.129011186239425,FALSE
+"H2126","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.42313,1.25,0.162,3429,0.759,"GSTA3, ALDH3B2, GSTK1, ALDH3B1, CYP2A7, CYP2A6, CYP2D6, GSTM5, GSTZ1, GSTA4, GSTO2, GSTM3, MGST1, FMO5, ALDH1A3",0.790484985457369,0.11975822410452,FALSE
+"H2126","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.35672,1.05,0.367,1174,1,"CES1, TYMP, CYP2A7, GUSB, CYP2A6",0.435333935747911,0,FALSE
+"H2126","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.24668,-0.852,0.664,14988,0.807,"COL4A4, GP1BB, ITGA7, ITGA9, COL11A1, ITGA11, RELN, COL5A3, COL6A3, THBS2, COL3A1, LAMA4, ITGAV, COL11A2, ITGB3, THBS1, COL1A2, COL4A6, SPP1, ITGA4, LAMA1, ITGB8, LAMA2, COL4A2, COL5A2, THBS4, SV2A, COL5A1, ITGA6, SDC2, FN1, TNC, COL6A2, HMMR, COL4A1",0.177831920631982,0.0931264652779296,FALSE
+"H2126","Input","KEGG_ENDOCYTOSIS",0.30523,0.913,0.577,3795,1,"CHMP1B, HSPA1L, ARFGAP3, PLD1, ARRB1, CHMP2A, ARFGAP1, USP8, PLD2, RAB11B, STAM2, ARRB2, CBLC, CHMP5, VPS45, EPN3, PIP5K1B, SMURF1, IQSEC2, VPS36, GRK2, ARAP2, SH3GLB2, AP2A1, TFRC, IGF1R, VPS28, CHMP3, RAB11FIP4, RAB31, ERBB3, HSPA1A, WWP1, PSD4, RAB5B, FGFR3, VPS37C, ASAP2, HSPA1B, CHMP2B, HSPA2, ITCH, CHMP4B",0.238824186844269,0,FALSE
+"H2126","Input","KEGG_ENDOMETRIAL_CANCER",-0.21223,-0.747,0.852,15187,0.934,"PIK3CD, FOXO3, MAP2K1, MLH1, EGF, GSK3B, ELK1, LEF1, PIK3R1, RAF1, TP53, TCF7, BAD, HRAS, NRAS, AKT3",0.0695604052332999,0.0296531237699066,FALSE
+"H2126","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.19245,0.565,0.98,5904,1,"ATP6V1B1, ATP6V0A4, ATP6AP1, IKBKB, RELA, TCIRG1, PLCG2, MAPK13, F11R, ATP6V0B, ADAM10, IKBKG, ATP6V0E2, ATP6V1G1, MAPK11, CCL5, PAK1, ATP6V1F, ATP6V1E2, IGSF5, NFKBIA, ADAM17, EGFR",0.00877392430750515,0,FALSE
+"H2126","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.18735,0.549,0.988,4693,1,"GAB1, CBLC, ERBB2, BTC, CAMK2G, SOS2, PAK4, PAK6, PLCG2, PIK3R3, ERBB3, AKT1, MAP2K7, MAPK3, STAT5B, SOS1, PRKCG, MTOR, MAPK1, NRG4, AREG",0.00524305541237188,0,FALSE
+"H2126","Input","KEGG_ETHER_LIPID_METABOLISM",0.49491,1.45,0.0542,4713,0.632,"PLA2G6, PLD1, PAFAH2, PLD2, PLA2G12A, PLA2G10, PLPP3, PLA2G2D, PLA2G2C, PLA2G4A, PAFAH1B2, PLA2G4B, LPCAT1",1.26600071346161,0.199282921717615,FALSE
+"H2126","Input","KEGG_FATTY_ACID_METABOLISM",0.3501,1.04,0.373,4233,1,"CYP4A22, CPT1B, ACADM, ACSL1, CPT2, ACSL3, ACOX3, ACADS, ALDH2, ALDH3A2, ACAA1, CPT1C, HADHB",0.428291168191312,0,FALSE
+"H2126","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.27487,0.805,0.785,4709,1,"PLA2G6, VAV1, PLA2G12A, PLA2G10, SOS2, PLCG2, PLA2G2D, PIK3R3, MAPK13, AKT1, MAP2K7, PLA2G2C, VAV2, MAPK3, PRKCD, PLA2G4A, SOS1, MAPK1, PLA2G4B, VAV3, MAPK11",0.105130343254747,0,FALSE
+"H2126","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.22207,0.657,0.941,4703,1,"PLA2G6, PLD1, VAV1, PLD2, PIP5K1B, PLPP3, WASL, ARPC1A, PLCG2, PIK3R3, AKT1, ARPC1B, VAV2, ASAP2, MAPK3, VASP, PRKCD, PLA2G4A, PRKCG, MYO10, MAPK1, PLA2G4F, WASF3, PLA2G4B, VAV3",0.0264103765727431,0,FALSE
+"H2126","Input","KEGG_FOCAL_ADHESION",-0.27255,-0.974,0.403,14988,0.643,"COL4A4, ITGA7, ITGA9, RAC1, PIK3CD, COL11A1, CAV1, ACTN2, ITGA11, MAP2K1, RELN, EGF, COL5A3, SHC4, PGF, COL6A3, PDGFRA, THBS2, MYLK2, PRKCA, COL3A1, LAMA4, MYLPF, CCND2, SHC3, ITGAV, PAK3, MYL5, GSK3B, COL11A2, ITGB3, DOCK1, THBS1, PDGFRB, COL1A2, ELK1, COL4A6, SPP1, ITGA4, MAPK10, LAMA1, ITGB8, PIK3R1, RAF1, LAMA2, COL4A2, SHC2, VCL, FLNC, COL5A2, THBS4, CDC42, PARVA, COL5A1, RHOA, PPP1CC, MYL9, ITGA6, BCL2, JUN, MYLK, FN1, TNC, VEGFB, COL6A2, ACTN1, BAD, ACTG1, COL4A1, HRAS, PDGFC, AKT3, ACTB, FYN, FLNA",0.39469495385889,0.191789027075778,FALSE
+"H2126","Input","KEGG_FOLATE_BIOSYNTHESIS",0.37341,1.1,0.313,3757,0.915,"PTS, GCH1, SPR, QDPR",0.504455662453552,0.0385789059335517,FALSE
+"H2126","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.33426,0.969,0.483,3315,1,"GMPPA, FBP1, HK2, FPGT, PHPT1, GMDS, PFKFB2, GMPPB",0.316052869248488,0,FALSE
+"H2126","Input","KEGG_GALACTOSE_METABOLISM",0.38366,1.13,0.266,5813,0.953,"HK2, B4GALT1, GAA, GALK2, PGM1, B4GALT2, GLA, MGAM, PGM2, GLB1, UGP2, GALT, G6PC2, GALE",0.575118363368933,0.0209070993616736,FALSE
+"H2126","Input","KEGG_GAP_JUNCTION",-0.29855,-1.1,0.264,15131,0.588,"TUBA4A, DRD2, GNAI3, PLCB3, MAP2K1, EGF, PDGFRA, MAPK7, GUCY1A2, PRKCA, PRKG1, GUCY1A1, MAP3K2, PDGFRB, TUBB4A, ADCY1, RAF1, PRKACA, GUCY1B1, TUBB4B, TUBA1B, GJA1, TUBB2B, GNAI1, TUBA1A, HRAS, CDK1, NRAS, PDGFC, TUBB, ADCY7, TUBB6, GNAI2, TUBB2A",0.578396073130169,0.230622673923862,FALSE
+"H2126","Input","KEGG_GLIOMA",-0.27635,-0.975,0.4,15187,0.685,"PIK3CD, MAP2K1, EGF, SHC4, PDGFRA, PRKCA, SHC3, PDGFRB, CDKN1A, PIK3R1, RAF1, E2F2, SHC2, E2F3, TP53, CDK6, CDKN2A, HRAS, CALM2, NRAS, AKT3, CDK4",0.397940008672038,0.164309428507574,FALSE
+"H2126","Input","KEGG_GLUTATHIONE_METABOLISM",0.38098,1.14,0.271,3980,0.964,"GSTA3, GSTK1, TXNDC12, G6PD, GSTM5, GSTZ1, OPLAH, GSTA4, GSTO2, GSTM3, GCLC, MGST1, GPX2, IDH2, GSR, MGST2, GPX3",0.567030709125594,0.0159229660971692,FALSE
+"H2126","Input","KEGG_GLYCEROLIPID_METABOLISM",0.26236,0.768,0.819,5940,1,"AKR1A1, DGAT1, PLPP3, TKFC, DGKE, MBOAT1, DGAT2, ALDH2, ALDH3A2, GLA, LCLAT1, GPAT4, DGKQ, AGPAT4, MGLL, GPAT2, PLPP2, AGK",0.0867160982395816,0,FALSE
+"H2126","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40279,1.18,0.213,4713,0.94,"PISD, LPGAT1, PLA2G6, PLD1, CHKB, PLD2, PLA2G12A, CDS1, PLA2G10, PLPP3, PEMT, PLA2G2D, CRLS1, DGKE, MBOAT1, PLA2G2C, PLA2G4A, LCLAT1, GPAT4, DGKQ, PTDSS2, PLA2G4B, AGPAT4, LPCAT1",0.671620396561262,0.0268721464003014,FALSE
+"H2126","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.395,1.16,0.246,5552,0.963,"AGXT, AOC2, CTH, AOC3, DMGDH, GATM, MAOA, AMT, SRR, GAMT, DLD, GCAT",0.609064892896621,0.0163737128754655,FALSE
+"H2126","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.2415,0.708,0.876,5481,1,"ALDH3B2, ALDH3B1, LDHC, AKR1A1, FBP1, HK2, PGM1, GALM, ACSS2, PGAM2, ALDH2, ALDH1A3, ALDH3A2, DLAT, BPGM, PDHA1, PGM2, PGK2, LDHA, DLD, LDHAL6B",0.0574958938319193,0,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.27556,0.803,0.75,5075,1,"CSGALNACT1, XYLT1, B4GALT7, CHST11, CHST15, CHST12, XYLT2, CHSY1, CHPF",0.1249387366083,0,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.29535,0.867,0.674,2944,1,"XYLT1, HS6ST1, HS6ST2, HS6ST3, B4GALT7",0.17134010346468,0,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.50905,1.5,0.0537,2407,0.532,"B3GNT7, B4GALT4, ST3GAL1, B4GALT1, B3GNT2, CHST6",1.27002571430044,0.274088367704952,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.60147,1.77,0.00804,5672,0.761,"HGSNAT, NAGLU, HYAL1, IDUA, GUSB, HYAL4, GNS, HYAL2, GALNS, IDS, HEXB, GLB1, HPSE",2.09474395125155,0.118615343229427,FALSE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.23299,0.683,0.916,5605,1,"ST3GAL1, B3GALT4, SLC33A1, ST6GALNAC4, HEXB, GLB1",0.0381045263321496,0,FALSE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.45542,1.34,0.118,5491,0.791,"FUT2, ST3GAL1, NAGA, GBGT1, A4GALT, GLA, HEXB, FUT1",0.928117992693875,0.101823516502323,FALSE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.53373,1.56,0.0378,2364,0.423,"B4GALT4, ST3GAL4, FUT2, FUT3, B3GNT3, B4GALT1, ABO, B3GNT2",1.42250820016277,0.373659632624958,FALSE
+"H2126","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.54041,1.58,0.031,4759,0.505,"PIGO, PIGT, PIGF, PIGU, DPM2, GPAA1, PIGL, PIGH, PIGZ, PIGV, PIGK, GPLD1, PIGS, PIGB, PIGP",1.50863830616573,0.296708621881339,FALSE
+"H2126","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.24867,0.728,0.869,5325,1,"MTHFD2L, AFMID, ACO2, MTHFD2, MDH2, GRHPR",0.0609802235513335,0,FALSE
+"H2126","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.35081,1.03,0.399,4746,1,"ADCY5, CGA, MAP3K4, ADCY4, PLA2G6, PLD1, CALML6, ITPR1, CACNA1D, PLD2, PLA2G12A, PLA2G10, CAMK2G, SOS2, ADCY6, ATF4, PLA2G2D, MAPK13, MAP2K7, PLA2G2C, MAPK3, PRKCD, PLA2G4A, SOS1, PLCB1, MAPK1, CACNA1F, GNAQ, PLA2G4B, MAPK11, LHB",0.399027104313252,0,FALSE
+"H2126","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.49648,-1.79,0.0368,10721,0.482,"KIR2DL1, CD28, KIR3DL2, IL2, KLRC1, KIR3DL1, KIR2DL3, FASLG, CD80, IL6, PRF1, CD86, TNF, GZMB, IL1A, IL1B, FAS",1.43415218132648,0.31695296176115,FALSE
+"H2126","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.37973,1.11,0.298,1742,0.94,"WNT3A, CSNK1E, WNT4, WNT7B, BMP6, WNT11, BMP7, BMP8B",0.525783735923745,0.0268721464003014,FALSE
+"H2126","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.32319,0.953,0.52,5962,1,"CD38, CD14, EPO, CD4, IL9R, CD55, ITGA1, TFRC, ITGA2B, EPOR, CD22, KITLG, CD19, IL1R1, GP1BA, TPO, CD37, CD5, IL1R2, IL4R, CD59, DNTT, IL7, FCGR1A, ITGA3",0.283996656365201,0,FALSE
+"H2126","Input","KEGG_HISTIDINE_METABOLISM",0.52547,1.56,0.036,636,0.423,"HAL, AMDHD1, ALDH3B2, ALDH3B1, BUD23",1.44369749923271,0.373659632624958,FALSE
+"H2126","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.27595,0.801,0.769,7114,1,"RAD52, BLM, POLD4, MRE11, SEM1, XRCC3, NBN, TOP3B, BRCA2, EME1, RAD50, RAD54B, MUS81, XRCC2, POLD3, RAD51D",0.114073660198569,0,FALSE
+"H2126","Input","KEGG_HUNTINGTONS_DISEASE",-0.28479,-1.01,0.365,16178,0.633,"NDUFB3, CLTB, DNALI1, DNAH1, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, DCTN4, VDAC2, NDUFB8, ATP5F1C, NDUFA9, NDUFAB1, SDHB, TFAM, POLR2D, AP2S1, COX4I1, TP53, BDNF, AP2M1, UQCRC1, NDUFB5, NDUFA1, CREB5, CLTA, HDAC2, ATP5MC3, ATP5PF, NDUFS3, COX8A, BBC3, ATP5PO, IFT57, HDAC1, NDUFS4, NDUFB6, TBPL1, ATP5F1A, HIP1, POLR2E, GPX1",0.437707135543525,0.198596289982645,FALSE
+"H2126","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.28411,0.828,0.718,2736,1,"CACNB2, CACNG1, PRKAB1, TNNI3, PRKAG1, PRKAA2, CACNA1D, ITGB6, ITGB5, ITGA1, CACNG6, ITGA2B",0.1438755557577,0,FALSE
+"H2126","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.24748,0.729,0.86,4850,1,"OCRL, ALDH6A1, INPP4A, PIP4K2C, PIP5K1B, ITPK1, PLCG2, PI4KB, INPP5B, INPPL1, INPP5K, IMPA2, PLCB1, PIK3C2A, IPMK",0.0655015487564323,0,FALSE
+"H2126","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.35765,1.04,0.377,4207,1,"PRKAB1, IRS2, INS, PHKA1, PPP1R3B, PRKAG1, GYS1, CALML6, FBP1, HK2, PRKAA2, PTPRF, MKNK1, CBLC, PPP1R3D, IKBKB, SOCS2, TSC1, ACACB, PHKA2, SOS2, SREBF1, PPP1R3C, PIK3R3, PYGL, AKT1, RPTOR, FOXO1, FASN, ACACA, MAPK3, SOCS4, MKNK2, PRKAB2, PHKG1, PRKAA1, SOS1, INPP5K, MTOR",0.423658649794207,0,FALSE
+"H2126","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.23361,-0.815,0.725,15219,0.869,"MAP3K14, CXCL12, CCL27, IL15, CXCR4, ITGA4, CCR10, MADCAM1, TGFB1",0.139661993429006,0.0609802235513335,FALSE
+"H2126","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27339,0.806,0.747,4429,1,"EPO, SPRY3, IFNL3, JAK1, JAK3, IL9R, IL13RA1, STAT3, PIAS3, STAM2, CBLC, SOCS2, CSF2RB, SOS2, GH2, PTPN6, PIK3R3, SOCS7, STAT2, TYK2, AKT1, CLCF1, EPOR, STAT5B, SOCS4, EP300, OSMR, IL20RA, SOS1, IFNL2, STAT6, TPO",0.126679398184601,0,FALSE
+"H2126","Input","KEGG_LEISHMANIA_INFECTION",0.23567,0.691,0.89,3758,1,"NCF4, ITGB2, JAK1, IRAK4, RELA, PTPN6, MAPK13, TAB1, MAPK3, MYD88, ITGB1",0.0506099933550872,0,FALSE
+"H2126","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.25033,0.731,0.843,5306,1,"CDH5, NCF4, ITGB2, VAV1, RAPGEF4, RAPGEF3, CLDN3, CTNND1, ITGAL, CLDN20, CLDN7, PLCG2, PIK3R3, TXK, MAPK13, ARHGAP35, F11R, VAV2, CLDN4, VASP, RASSF5, OCLN, ROCK1, ITGB1, SIPA1, PRKCG, CLDN9, VAV3, MAPK11, PXN, CTNNA1, AFDN, CLDN8, CYBB",0.0741724253752577,0,FALSE
+"H2126","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.41231,-1.51,0.0544,17832,0.574,"ALDH1B1, ECHS1, ALDH9A1",1.26440110030182,0.241088107602027,FALSE
+"H2126","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.45089,1.31,0.13,5251,0.789,"PLA2G6, PLA2G12A, CYP2J2, PLA2G10, PLA2G2D, PLA2G2C, PLA2G4A, CYP3A43, PLA2G4B, ALOX15, CYP3A7",0.886056647693163,0.10292299679058,FALSE
+"H2126","Input","KEGG_LONG_TERM_DEPRESSION",0.28697,0.847,0.71,4629,1,"PLA2G6, RYR1, ITPR1, PLA2G12A, PLA2G10, PRKG2, IGF1R, GNAO1, PLA2G2D, CACNA1A, PLA2G2C, MAPK3, PPP2R1B, PLA2G4A, PRKCG, PLCB1, MAPK1, GNAQ, PLA2G4B",0.148741651280925,0,FALSE
+"H2126","Input","KEGG_LONG_TERM_POTENTIATION",0.24903,0.729,0.861,4541,1,"GRIN2D, GRIN1, CALML6, ITPR1, RPS6KA2, RPS6KA6, RAPGEF3, CAMK2G, ATF4, MAPK3, EP300, PRKCG, PLCB1, MAPK1, GNAQ",0.0649968485463452,0,FALSE
+"H2126","Input","KEGG_LYSINE_DEGRADATION",0.23752,0.691,0.896,3759,1,"SETDB1, SETD7, EHMT1, KMT5B, ASH1L, KMT5C, AASDH, ALDH2, ALDH3A2, AASDHPPT",0.0476919903378748,0,FALSE
+"H2126","Input","KEGG_LYSOSOME",0.4666,1.38,0.0874,5816,0.733,"SLC11A1, HGSNAT, PPT1, GM2A, CTSL, NAGLU, ARSA, FUCA1, HYAL1, ATP6V0A4, IDUA, GUSB, SLC11A2, CLN3, ATP6AP1, LGMN, AP3S2, NAGA, CTSA, GGA1, AP4M1, AGA, GAA, GALC, LAMP1, GNPTG, ASAH1, SLC17A5, GNS, TCIRG1, CTSH, DNASE2, CD63, CTSF, LAPTM4A, MFSD8, CTSD, AP1M2, ARSG, AP1G1, ATP6V0B, MAN2B1, CLN5, GALNS, LIPA, LAMP3, GLA, SORT1, AP3M1, NPC1, AP3D1, IDS, GGA3, NAGPA, CD68, ACP2, PSAP, MANBA, HEXB, GBA, CTSC, GLB1, ABCA2, CTSS, LAMP2, AP3B1",1.0584885673656,0.134896025358872,FALSE
+"H2126","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26325,0.778,0.818,4631,1,"CACNB2, CACNG1, CACNA1I, CD14, MAP3K4, HSPA1L, PLA2G6, ARRB1, DUSP16, NR4A1, RPS6KA2, TGFBR1, TRAF2, CACNA1D, FGF12, MAP3K8, PLA2G12A, RPS6KA6, FGF19, DUSP8, ARRB2, MKNK1, IKBKB, RELA, MAPK8IP2, PLA2G10, GADD45B, DUSP4, SOS2, ATF4, MAP3K5, FGF11, PDGFB, CACNG6, PLA2G2D, RASGRP3, MAPK13, AKT1, TAOK1, CACNA1A, RPS6KA5, MAP4K3, HSPA1A, MAP2K7, TAB1, PLA2G2C, FGFR3, MAP3K11, MAPK3, HSPA1B, STK3, MKNK2, HSPA2, TAOK3, IL1R1, IKBKG, PLA2G4A, DUSP1, MAPKAPK2, SOS1, RRAS, PRKCG, MAPK1, TNFRSF1A, CACNG8, NLK, CACNG4, CACNA1F, PLA2G4B, GADD45G",0.087246696328677,0,FALSE
+"H2126","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.31047,0.902,0.62,1738,1,"INS, BHLHA15, FOXA3",0.207608310501746,0,FALSE
+"H2126","Input","KEGG_MELANOGENESIS",0.32653,0.959,0.507,1246,1,"WNT3A, FZD10, ADCY5, MC1R, ADCY4, WNT4, CREB3L4, CALML6, WNT7B, WNT11",0.294992040666664,0,FALSE
+"H2126","Input","KEGG_MELANOMA",-0.3336,-1.17,0.237,15187,0.666,"PIK3CD, FGF18, MAP2K1, EGF, PDGFRA, FGFR1, FGF5, PDGFRB, FGF13, CDKN1A, FGF1, PIK3R1, RAF1, E2F2, FGF22, E2F3, TP53, CDK6, CDKN2A, FGF2, BAD, HRAS, NRAS, PDGFC, AKT3, CDK4",0.625251653989896,0.176525770829699,FALSE
+"H2126","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41418,1.22,0.193,4313,0.815,"GSTA3, ALDH3B2, GSTK1, ALDH3B1, CYP1B1, GSTM5, GSTZ1, GSTA4, GSTO2, GSTM3, MGST1, ALDH1A3, AKR1C2, MGST2, DHDH, CYP2F1, CYP3A43",0.714442690992226,0.0888423912600234,FALSE
+"H2126","Input","KEGG_MISMATCH_REPAIR",-0.37099,-1.31,0.158,14311,0.739,"RPA1, POLD2, RFC3, MSH6, MLH1, PCNA, RPA2, RFC1, RPA3, RFC5, RFC4, RFC2",0.801342913045577,0.131355561605174,FALSE
+"H2126","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.43345,1.27,0.156,4516,0.743,"INS, CAB39, RPS6KA2, RICTOR, PRKAA2, RPS6KA6, TSC1, PIK3R3, CAB39L, AKT1, RPTOR, MAPK3, VEGFC, PRKAA1, ULK3, VEGFA, MTOR, EIF4B, MAPK1, VEGFD, ULK1",0.806875401645538,0.129011186239425,FALSE
+"H2126","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.14128,-0.522,1,12416,0.997,"IFNA13, RAET1G, HCST, CHP2, PLCG1, ICAM1, IFNA21, PPP3CB, IFNGR1, PRKCB, PRF1, NFAT5, IFNA8, PPP3CC, PIK3CG, TNFRSF10C, IFNA1, CD247, TNF, IFNA5, CASP3, IFNB1, GZMB, PPP3R2, LCK, NFATC1, RAC1, PIK3CD, MAP2K1, ULBP1, SHC4, RAET1L, PRKCA, CSF2, SHC3, PPP3R1, ICAM2, PIK3R1, RAF1, TNFRSF10B, NFATC2, SHC2, FAS, ULBP2, ULBP3, HRAS, MICB, NRAS, FYN",0,0.00130484168834428,FALSE
+"H2126","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34377,0.995,0.434,2843,1,"VIPR2, BDKRB2, GHSR, GALR3, P2RY6, CGA, MLNR, BDKRB1, MC1R, SSTR1, F2RL3, P2RX4, GRIN2D, ADORA1, GRIN1, ADRA1D, TRPV1, PTAFR, S1PR4, GABRR2, P2RX2, GABRA3, GABRB3, P2RY2, PLG, GLP2R, DRD4, GH2, LTB4R2, OPRL1, TACR3, LTB4R, TRHR, GRM3",0.362510270487489,0,FALSE
+"H2126","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.20862,-0.743,0.857,14936,0.895,"NTRK2, NTRK3, RAC1, IRAK3, PIK3CD, FOXO3, MAPK14, MAP2K1, SHC4, YWHAG, KIDINS220, MAPK7, NTF3, SHC3, GSK3B, NGF, NGFR, RPS6KA4, YWHAE, NFKBIE, CSK, MAPK10, TP73, PIK3R1, RAF1, IRS1, SHC2, CAMK4, CDC42, RHOA, TP53, BDNF, BCL2, JUN, YWHAQ, SH2B3, BAD, HRAS, CALM2, NRAS, AKT3, ARHGDIA, MAP3K3",0.0670191780768018,0.048176964684088,FALSE
+"H2126","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38503,1.13,0.268,2820,0.953,"CD38, NADK, NADSYN1, NT5C2, NMRK1, NAMPT, NMNAT1",0.571865205971211,0.0209070993616736,FALSE
+"H2126","Input","KEGG_NITROGEN_METABOLISM",0.42711,1.25,0.148,1139,0.759,"HAL, GLUL, CTH",0.829738284605043,0.11975822410452,FALSE
+"H2126","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.25334,0.746,0.86,6235,1,"NOD2, TAB3, XIAP, IKBKB, RELA, MAPK13, BIRC3, TAB1, MAPK3, CXCL2, IKBKG, CARD8, BIRC2, MAPK1, MAPK11, CCL5, NFKBIB, NFKBIA, CASP8, ERBIN, CASP1, MAPK12, NLRP1",0.0655015487564323,0,FALSE
+"H2126","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.41668,-1.39,0.093,17589,0.735,"PRKDC, XRCC5, XRCC4, FEN1, NHEJ1",1.03151705144606,0.133712660915805,FALSE
+"H2126","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.24966,-0.909,0.511,17114,0.723,"PIK3R1, RAF1, E2F2, E2F3, TP53, CDK6, CDKN2A, BAD, HRAS, NRAS, AKT3, CDK4",0.291579099865287,0.140861702705469,FALSE
+"H2126","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.23814,0.704,0.896,4437,1,"NUMB, MAML3, APH1A, RFNG, NOTCH3, PSEN1, DTX1, KAT2A, EP300, DVL1, CTBP1, PSENEN, DTX3",0.0476919903378748,0,FALSE
+"H2126","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.32406,-1.14,0.254,16205,0.623,"POLE3, PCNA, RPA2, POLE, RFC1, GTF2H1, RPA3, RFC5, ERCC8, CCNH, GTF2H3, RFC4, RFC2",0.595166283380062,0.20551195334083,FALSE
+"H2126","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.57278,1.68,0.0231,4082,0.517,"MGAT4A, DPAGT1, MAN2A2, ST6GAL1, MOGS, RPN2, ALG2, MGAT5B, ALG13, STT3A, MAN1B1, B4GALT1, DPM2, ALG6, ALG8, ALG3, DOLPP1, ALG12, ALG10B, ALG11, RPN1, DDOST, ALG5, B4GALT2, DPM3",1.63638802010786,0.286509456906058,FALSE
+"H2126","Input","KEGG_OLFACTORY_TRANSDUCTION",0.26721,0.762,0.815,2307,1,"OR1I1, OR10H2, OR6Q1, OR1F1, OR8B8, OR2A14, OR52B4, GUCA1B, OR6B1, OR10AD1, CALML6, OR52K1, OR2A12, GUCY2D, ARRB2, CNGB1, PRKG2, OR10A3, CAMK2G, OR11H1, OR2A2",0.0888423912600234,0,FALSE
+"H2126","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.3714,-1.34,0.115,17549,0.752,"SHMT2, TYMS, MTR, DHFR",0.939302159646388,0.123782159408358,FALSE
+"H2126","Input","KEGG_OOCYTE_MEIOSIS",0.22124,0.644,0.945,2630,1,"ADCY5, ADCY4, SMC1B, INS, CALML6, ANAPC2, ITPR1, RPS6KA2, RPS6KA6, SLK, CDC16, CAMK2G, ADCY6, IGF1R, STAG3, ANAPC5",0.0245681914907371,0,FALSE
+"H2126","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.65357,1.9,0.00686,5781,0.63,"FUCA1, MAN2C1, AGA, MAN2B2, ENGASE, MAN2B1, MANBA, HEXB, GBA, GLB1, NEU3",2.16367588429325,0.200659450546418,FALSE
+"H2126","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.28498,-1.01,0.388,15908,0.633,"COX7C, ATP5MF, NDUFB3, NDUFA11, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, ATP6V1G2, NDUFB8, ATP6V0A2, ATP6V0D1, ATP5F1C, NDUFA9, NDUFAB1, PPA1, SDHB, COX4I1, UQCRC1, NDUFB5, NDUFA1, ATP6V1A, ATP6V0E1, ATP5MC3, ATP5PF, ATP6V1B2, NDUFS3, COX8A, ATP5PO, NDUFS4, NDUFB6, ATP5F1A, ATP6V1H",0.411168274405793,0.198596289982645,FALSE
+"H2126","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.44008,1.28,0.127,3870,0.794,"GCNT3, GALNT6, GALNT12, B3GNT6, ST3GAL1, ST6GALNAC1, GALNT3, GALNT14, GALNT4, C1GALT1C1, C1GALT1, GALNT7, GALNT10",0.896196279044043,0.100179497572904,FALSE
+"H2126","Input","KEGG_P53_SIGNALING_PATHWAY",-0.35516,-1.26,0.164,15946,0.651,"CCND2, COP1, PMAIP1, RRM2, THBS1, PPM1D, CCNE2, CDKN1A, SESN1, TP73, TNFRSF10B, SERPINE1, FAS, SESN3, TP53, CDK6, STEAP3, CDKN2A, GADD45A, CCNB2, SESN2, CDK1, BBC3, CDK4, CCNG1, CCNB1",0.785156151952302,0.186419011431808,FALSE
+"H2126","Input","KEGG_PANCREATIC_CANCER",0.23745,0.701,0.885,4562,1,"CASP9, JAK1, PLD1, TGFBR1, STAT3, IKBKB, RELA, ERBB2, PIK3R3, AKT1, MAPK3, VEGFC, SMAD2, IKBKG, VEGFA, RALBP1, MAPK1, VEGFD, RALB",0.0530567293021746,0,FALSE
+"H2126","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3343,0.984,0.474,5018,1,"PPCS, BCAT2, COASY, PPCDC, ENPP1, PANK2",0.324221658325915,0,FALSE
+"H2126","Input","KEGG_PARKINSONS_DISEASE",-0.20922,-0.743,0.887,15759,0.895,"UBE2J2, NDUFB10, COX7C, HTRA2, NDUFB3, SDHC, NDUFA8, COX6B2, UQCRQ, NDUFA2, VDAC2, NDUFB8, ATP5F1C, NDUFA9, NDUFAB1, SDHB, COX4I1, UQCRC1, NDUFB5, NDUFA1, ATP5MC3, ATP5PF, NDUFS3, COX8A, ATP5PO, NDUFS4, NDUFB6, ATP5F1A",0.0520763801682736,0.048176964684088,FALSE
+"H2126","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.4175,-1.53,0.0492,16563,0.673,"ARHGEF2, TLR4, TUBB4A, LY96, TUBB4B, ARPC5L, NCL, CDC42, RHOA, TUBA1B, YWHAQ, TUBB2B, TUBA1A, ACTG1, ARPC4, TUBB, ARPC2, TUBB6, ACTB, FYN, TUBB2A",1.30803489723264,0.171984935776023,FALSE
+"H2126","Input","KEGG_PATHWAYS_IN_CANCER",0.1848,0.54,0.989,4372,0.997,"WNT3A, FZD10, CASP9, ARNT2, JAK1, WNT4, PLD1, TRAF4, EPAS1, WNT7B, TGFBR1, TRAF2, STAT3, PIAS3, FGF12, WNT11, FGF19, CBLC, XIAP, IKBKB, EGLN2, RELA, ARNT, ERBB2, RXRA, SOS2, IGF1R, FGF11, PDGFB, PLCG2, PIK3R3, CDH1, ITGA2B, BAX, JUP, LAMA3, AKT1, BIRC3, LAMA5, FOXO1, FGFR3, KITLG, MAPK3, STAT5B, VEGFC, RASSF5, EP300, ITGB1, WNT9A, SMAD2, IKBKG, DVL1, CTBP1, SOS1, PRKCG, VEGFA, MTOR, RALBP1, BIRC2, BID, MAPK1, VEGFD",0.0048037084028206,0.00130484168834428,FALSE
+"H2126","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.32989,0.976,0.499,6463,1,"GUSB, UGDH, DHDH, CRYL1, UGP2, DCXR, RPEL1",0.30189945437661,0,FALSE
+"H2126","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.39083,1.15,0.247,5330,0.949,"G6PD, FBP1, PRPS1, TKTL1, H6PD, PGM1, PRPS1L1, PRPS2, TKT, PGLS, PGM2, PGD, RBKS",0.607303046740334,0.0227337875727074,FALSE
+"H2126","Input","KEGG_PEROXISOME",0.39474,1.15,0.245,4935,0.949,"AGXT, PEX11A, GSTK1, ECH1, PEX1, ABCD1, ACSL1, SLC27A2, ACSL3, SCP2, PXMP4, ACOX3, PEX11G, AMACR, PEX12, PEX2, CROT, PEX11B, PEX13, ABCD4, EPHX2, HMGCL, IDH2, ACAA1, PEX7, XDH, PMVK, MPV17, NUDT19, MLYCD, CRAT, IDH1, PEX26, SLC25A17",0.610833915635468,0.0227337875727074,FALSE
+"H2126","Input","KEGG_PHENYLALANINE_METABOLISM",0.55039,1.62,0.027,4471,0.454,"ALDH3B2, ALDH3B1, AOC2, TAT, AOC3, ALDH1A3, NAA80, MAOA",1.56863623584101,0.342944147142896,FALSE
+"H2126","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.27493,0.81,0.775,4316,1,"OCRL, CALML6, ITPR1, CDS1, INPP4A, PIP4K2C, PIP5K1B, ITPK1, PLCG2, PIK3R3, PI4KB, DGKE, INPP5B, INPPL1, INPP5K, PRKCG, IMPA2, PLCB1, DGKQ",0.11069829749369,0,FALSE
+"H2126","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.27303,0.791,0.754,5228,1,"GUSB, HMBS, CP, COX15, BLVRB, ALAD, BLVRA, PPOX",0.122628654130226,0,FALSE
+"H2126","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.37557,1.1,0.304,1877,0.915,"PLIN1, CYP4A22, CPT1B, ANGPTL4, ACADM, ACSL1, CPT2, SLC27A2, PPARA, ACSL3, SCP2, ACOX3, RXRA",0.517126416391246,0.0385789059335517,FALSE
+"H2126","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.26912,0.792,0.756,2706,1,"SCP2, AMACR, SLC27A5",0.121478204498793,0,FALSE
+"H2126","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.40324,1.17,0.215,3895,0.953,"BLNK, CD4, JAK3, CD40, ADA, CD19, IKBKG",0.667561540084395,0.0209070993616736,FALSE
+"H2126","Input","KEGG_PRION_DISEASES",-0.36092,-1.26,0.176,15924,0.651,"SOD1, IL1A, NCAM2, IL1B, ELK1, NOTCH1, NCAM1, PRKACA, C5, EGR1, STIP1, FYN",0.75448733218585,0.186419011431808,FALSE
+"H2126","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.28673,-1.05,0.306,16429,0.667,"MAD2L2, CCNA1, HSP90AA1, MAPK10, ADCY1, CDC25C, PIK3R1, RAF1, PRKACA, ANAPC13, CPEB1, PDE3B, PKMYT1, MAD2L1, BUB1, GNAI1, CCNB2, PLK1, CDK1, CCNA2, CDC25A, HSP90AB1, AKT3, ADCY7, GNAI2, CCNB1",0.51427857351842,0.175874166083451,FALSE
+"H2126","Input","KEGG_PROPANOATE_METABOLISM",0.37599,1.11,0.308,5481,0.94,"MCEE, LDHC, ACADM, ALDH6A1, ACACB, SUCLG2, ACSS2, ALDH2, ACACA, ALDH3A2, PCCB, MLYCD, LDHA, LDHAL6B",0.511449283499556,0.0268721464003014,FALSE
+"H2126","Input","KEGG_PROSTATE_CANCER",0.22319,0.656,0.929,4356,1,"CASP9, INS, CREB3L4, IKBKB, RELA, ERBB2, CREB3L2, SOS2, ATF4, IGF1R, PDGFB, PIK3R3, AKT1, FOXO1, MAPK3, CREB1, EP300, IKBKG, SOS1, MTOR, SRD5A2, MAPK1",0.0319842860063582,0,FALSE
+"H2126","Input","KEGG_PROTEASOME",-0.33383,-1.23,0.178,14960,0.664,"PSMB6, PSMB11, PSMD2, PSMC5, PSMD8, PSMD13, PSMA4, PSMB2, PSMD1, PSMD14, PSMA1, PSMB1, PSMC3, PSMA2, PSMB7, PSMD6",0.749579997691106,0.177831920631982,FALSE
+"H2126","Input","KEGG_PROTEIN_EXPORT",0.47612,1.41,0.0757,6187,0.67,"SRPRA, SRP54, SPCS2, IMMP1L, SEC61A1, OXA1L, SEC62, SPCS3, SPCS1, SRP72, HSPA5, SRPRB, SRP68, SEC61B, IMMP2L",1.12090412049993,0.173925197299174,FALSE
+"H2126","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.28306,-1.01,0.382,15771,0.633,"PCK2, ATP1A3, SLC38A3, MDH1, CA2, ATP1A1, GLS",0.417936637088291,0.198596289982645,FALSE
+"H2126","Input","KEGG_PURINE_METABOLISM",0.27774,0.809,0.745,4157,1,"ADCY5, ENTPD8, PDE4D, ADCY4, CANT1, PRUNE1, PDE8B, PDE4A, GUCY2D, PRPS1, POLR2J2, NT5C2, ENTPD2, ENTPD5, ADCY6, ENTPD6, POLR3F, POLR3GL, NME3, AK7, GMPR2, NUDT9, GDA, PRPS1L1, ADA, POLD4, PDE10A, POLR2J3, PAPSS2, PDE5A, PRPS2, ITPA, ENPP1, XDH, AMPD3, POLR2K",0.127843727251707,0,FALSE
+"H2126","Input","KEGG_PYRIMIDINE_METABOLISM",0.18309,0.535,0.997,4292,0.991,"ENTPD8, TYMP, CANT1, CMPK1, POLR2J2, NT5C2, ENTPD5, ENTPD6, POLR3F, POLR3GL, NME3, TXNRD1, POLD4, POLR2J3, ITPA, CAD, POLR2K, CTPS2, CDA",0.00130484168834428,0.00392634551472468,FALSE
+"H2126","Input","KEGG_PYRUVATE_METABOLISM",0.28879,0.84,0.706,5481,1,"LDHC, ACACB, LDHD, ACSS2, ALDH2, ACACA, PC, ALDH3A2, HAGH, DLAT, MDH2, PDHA1, ME1, LDHA, GRHPR, DLD, LDHAL6B",0.151195298948196,0,FALSE
+"H2126","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.20719,0.606,0.968,4066,1,"BDKRB2, BDKRB1, CD14, ITGB2, INS, VAV1, ARHGEF4, FGF12, FGF19, SLC9A1, ITGB6, SSH3, RDX, PIP4K2C, PIP5K1B, WASL, ITGB5, SOS2, ITGA1, MYH14, PAK4, PAK6, ARPC1A, ITGAL, FGF11, PDGFB, PIK3R3, ITGA2B, ARHGAP35, IQGAP1, ARPC1B, VAV2, FGFR3, ARHGEF1, MAPK3, ARHGEF12, ARHGEF7, ROCK1, ITGB1, FGD3, SOS1, TIAM1, RRAS",0.0141246426916063,0,FALSE
+"H2126","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.24372,0.714,0.881,5460,1,"INS, PRKAA2, ATG4C, PRKAA1, ULK3, ULK1, GABARAPL1, ULK2, BECN2",0.0550240915879521,0,FALSE
+"H2126","Input","KEGG_RENAL_CELL_CARCINOMA",0.25122,0.743,0.847,4372,1,"ARNT2, GAB1, EPAS1, EGLN2, ARNT, SOS2, PAK4, PAK6, PDGFB, PIK3R3, AKT1, MAPK3, VEGFC, EP300, SOS1, VEGFA, MAPK1, VEGFD",0.0721165896692931,0,FALSE
+"H2126","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32455,0.951,0.511,2328,1,"CTSA, ACE2, NLN",0.291579099865287,0,FALSE
+"H2126","Input","KEGG_RETINOL_METABOLISM",0.4369,1.3,0.114,4313,0.788,"CYP4A22, CYP2A7, RDH10, DGAT1, CYP2A6, RDH16, CYP26B1, PNPLA4, DHRS3, ALDH1A2, DGAT2, RDH11, CYP26C1, CYP3A43",0.943095148663527,0.103473782510445,FALSE
+"H2126","Input","KEGG_RIBOFLAVIN_METABOLISM",0.55933,1.66,0.021,5192,0.411,"RFK, ACP6, PHPT1, ACP1, FLAD1, ENPP1, ACP2",1.67778070526608,0.386158178123931,FALSE
+"H2126","Input","KEGG_RIBOSOME",-0.24649,-0.913,0.633,17221,0.736,"RPS12, RPL29, RPS26, RPL22L1, FAU, RPL24, RPL35, RPL5, RPL15, RPL35A, RPL26L1, RPL32, RPL14, RPSA, RPS20, RPL17",0.198596289982645,0.133122185662501,FALSE
+"H2126","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.22133,0.666,0.932,6603,1,"IRF3, TRAF2, NLRX1, DHX58, IKBKB, RELA, TKFC, TRADD, MAPK13, TBK1, IKBKG, MAVS, TRAF3, OTUD5, MAPK11, NFKBIB, FADD, NFKBIA, DDX3X, CASP8, IFIH1, TRIM25, MAPK12, RIPK1, CASP10, TBKBP1",0.0305840876460186,0,FALSE
+"H2126","Input","KEGG_RNA_DEGRADATION",-0.3358,-1.15,0.247,17314,0.638,"EXOSC9, EXOSC7, LSM1, CNOT10, PATL1, EXOSC3, HSPD1, DCP2, LSM6, LSM5, LSM3, ENO2, DCP1B",0.607303046740334,0.195179321278838,FALSE
+"H2126","Input","KEGG_RNA_POLYMERASE",-0.19769,-0.705,0.855,17487,0.932,"POLR1E, POLR2D, POLR2E",0.0680338852718274,0.0305840876460186,FALSE
+"H2126","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.33451,0.976,0.489,3468,1,"BUD23, CTH, AHCYL1, METTL2B, HEMK1, AHCYL2, PAPSS2",0.31069114087638,0,FALSE
+"H2126","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.21519,0.631,0.955,3187,1,"CASP9, TRAF4, TRAF2, PIAS3, XIAP, IKBKB, RELA, RXRA, PIK3R3, APAF1, ITGA2B, LAMA3, AKT1, BIRC3, LAMA5",0.0199966284162537,0,FALSE
+"H2126","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.33582,0.992,0.45,4565,1,"GOSR2, BET1, BET1L, STX19, GOSR1, STX17, VAMP7, STX16, SNAP23, VAMP8, YKT6, VTI1B, SEC22B, VAMP4, STX1A",0.346787486224656,0,FALSE
+"H2126","Input","KEGG_SPHINGOLIPID_METABOLISM",0.28133,0.833,0.709,2479,1,"SGPP1, ARSA, DEGS2, PLPP3, GALC, ASAH1, ENPP7",0.149353764816933,0,FALSE
+"H2126","Input","KEGG_SPLICEOSOME",-0.31632,-1.12,0.268,16081,0.571,"PRPF18, SNRPD2, SF3B6, RBMX, CDC5L, SRSF3, MAGOHB, HNRNPU, SF3A2, LSM2, SNRPD1, HSPA8, SRSF1, HSPA6, HNRNPC, HNRNPA1, PPIL1, SYF2, SF3B3, ALYREF, HNRNPM, SRSF10, SNRPB, HNRNPK, U2SURP, PQBP1, HNRNPA1L2, TRA2B, SMNDC1, SF3B5, HNRNPA3, ISY1, SNRPE, SNRPC, U2AF1, LSM6, BCAS2, PRPF19, LSM5, LSM3, TXNL4A",0.571865205971211,0.243363891754152,FALSE
+"H2126","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.3691,1.1,0.317,5886,0.915,"GYS1, HK2, GUSB, UGDH, GAA, PGM1, PYGL, ENPP1, MGAM, PGM2, UGP2, G6PC2, PYGB",0.498940737782249,0.0385789059335517,FALSE
+"H2126","Input","KEGG_STEROID_BIOSYNTHESIS",0.45101,1.32,0.118,5705,0.788,"MSMO1, CYP27B1, LIPA, NSDHL, DHCR7, DHCR24, SC5D, TM7SF2",0.928117992693875,0.103473782510445,FALSE
+"H2126","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38017,1.12,0.29,4720,0.968,"SRD5A3, SULT2B1, CYP1B1, CYP11B1, HSD17B8, SRD5A1, COMT, AKR1C2, SRD5A2, CYP3A43, HSD17B2",0.537602002101044,0.0141246426916063,FALSE
+"H2126","Input","KEGG_SULFUR_METABOLISM",0.56845,1.66,0.015,4359,0.411,"SULT2B1, SULT1A3, SUOX, SULT1A4, PAPSS2, CHST11, SULT1A2, CHST12",1.82390874094432,0.386158178123931,FALSE
+"H2126","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.31191,-1.12,0.301,11837,0.571,"CTSG, FCGR2B, CD80, C9, IL10, C6, C7, CD86, FCGR2C, TNF, GRIN2A, SNRPD3, GRIN2B, ELANE, ACTN2, FCGR2A, SNRPD1, SSB, C5, C1R, SNRPB, ACTN1",0.521433504406157,0.243363891754152,FALSE
+"H2126","Input","KEGG_TASTE_TRANSDUCTION",0.43734,1.28,0.141,3465,0.794,"TAS2R3, TAS1R3, TAS2R4, ADCY4, SCNN1A, TAS2R38, ADCY6, TAS2R10, TAS2R5, TAS2R39, CACNA1A, TAS2R41",0.85078088734462,0.100179497572904,FALSE
+"H2126","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.28006,0.83,0.711,1945,1,"CSAD",0.148130399270234,0,FALSE
+"H2126","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.31235,0.923,0.559,4183,1,"DHDDS, MVD, PDSS2, PMVK",0.252588192113577,0,FALSE
+"H2126","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.22574,0.67,0.92,3917,1,"INHBB, TGFBR1, BMP6, SP1, BMP7, ID1, THBS3, BMP8B, SMURF1, LTBP1, ID3, RBL2, BMP8A, MAPK3, EP300, ROCK1, PPP2R1B, SMAD2, E2F5",0.0362121726544447,0,FALSE
+"H2126","Input","KEGG_THYROID_CANCER",-0.32728,-1.21,0.163,17604,0.662,"PAX8, NCOA4, TP53, TCF7, HRAS, NRAS",0.787812395596042,0.1791420105603,FALSE
+"H2126","Input","KEGG_TIGHT_JUNCTION",-0.22937,-0.799,0.744,15576,0.882,"CLDN11, CASK, CLDN22, JAM2, PARD3, PRKCA, MYLPF, PPP2R2A, MYL5, RAB3B, CSNK2A2, MYH9, PPP2R2B, MYH15, RRAS2, MRAS, LLGL1, MAGI2, JAM3, CDC42, TJAP1, RHOA, MYL9, GNAI1, ACTN1, ACTG1, HRAS, PARD6G, NRAS, MPDZ, CSNK2B, AKT3, CDK4, GNAI2, PPP2R2D, ACTB, EPB41L2",0.128427064454121,0.0545314148681803,FALSE
+"H2126","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.26952,0.801,0.758,3895,1,"LBP, CD14, TIRAP, IRAK4, IRF3, MAP3K8, IKBKB, RELA, PIK3R3, CD40, MAPK13, AKT1, MAP2K7, TAB1, TBK1, MAPK3, TLR3, MYD88, IKBKG",0.120330794367946,0,FALSE
+"H2126","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.28315,-0.974,0.418,16065,0.643,"TPH1, WARS2, AOX1, KYNU, OGDHL, CYP1A1, ALDH1B1, ECHS1, ACAT1, ALDH9A1, AADAT",0.378823718224965,0.191789027075778,FALSE
+"H2126","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.37967,1.11,0.285,4356,0.94,"IRS2, INS, HK2, CACNA1D, IKBKB, SOCS2, PIK3R3, CACNA1A, MAPK3, SOCS4, PRKCD, MTOR, MAPK1",0.54515513999149,0.0268721464003014,FALSE
+"H2126","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.46804,1.35,0.112,1507,0.797,"CPE, INS, ICA1, PTPRN2",0.950781977329818,0.0985416786038876,FALSE
+"H2126","Input","KEGG_TYROSINE_METABOLISM",0.48019,1.41,0.0734,2664,0.67,"TH, ALDH3B2, ALDH3B1, BUD23, HGD, AOC2, TAT, GSTZ1, METTL2B, AOC3, COMT, HEMK1",1.13430394008393,0.173925197299174,FALSE
+"H2126","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17101,-0.639,0.97,15187,0.978,"PIK3CD, MAP3K14, MAPK14, MAP2K1, CD8A, MAP3K7, CARD11, CSF2, RASGRP1, PAK3, GSK3B, PPP3R1, NFKBIE, DLG1, PIK3R1, RAF1, NFATC2, CDC42, RHOA, JUN, HRAS, NRAS, BCL10, AKT3, MALT1, CDK4, FYN",0.0132282657337552,0.00966114521239857,FALSE
+"H2126","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.22621,0.681,0.918,4294,1,"RHOBTB2, PPIL2, CUL7, ANAPC2, CUL5, PIAS3, CBLC, XIAP, FBXW8, UBOX5, UBE4A, CDC16, UBE2Q1, SMURF1, SYVN1, HERC1, UBE2Q2, FBXO4, UBE2H, NHLRC1, UBE2M, ANAPC5, DET1, UBE2G2, WWP1, BIRC3, MID1, HUWE1, ITCH, ANAPC11, BTRC, DDB2, UBE2G1, BIRC2",0.0371573187987575,0,FALSE
+"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3008,0.881,0.636,2403,1,"BCAT2, VARS2",0.196542884351586,0,FALSE
+"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30329,0.887,0.639,4339,1,"MCEE, ACAD8, ACADM, ALDH6A1, BCAT2, BCKDHA, AUH, OXCT2, ACADS, HMGCL, ALDH2, ALDH3A2, ACAA1, HADHB, PCCB",0.1944991418416,0,FALSE
+"H2126","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.28432,0.837,0.722,4652,1,"ADCY5, CYP4A22, ADCY4, PLA2G6, CALML6, ITPR1, ADRA1D, CACNA1D, PLA2G12A, PPP1R14A, PLA2G10, ADCY6, PRKCH, PLA2G2D, PLA2G2C, ARHGEF1, MAPK3, PRKCD, ARHGEF12, ROCK1, PLA2G4A, PRKCG, PLCB1, KCNMB3, MAPK1, CACNA1F, GNAQ, PLA2G4B, NPR2",0.141462802430361,0,FALSE
+"H2126","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.25984,0.779,0.8,3924,1,"AQP3, CREB3L4, RAB11B, NSF, CREB3L2, ADCY6, DYNC1LI2, RAB5B, CREB1, DYNC2LI1",0.0969100130080564,0,FALSE
+"H2126","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.25173,0.74,0.853,4798,1,"CASP9, PLA2G6, PLA2G12A, PLA2G10, PLCG2, PLA2G2D, PIK3R3, MAPK13, AKT1, PLA2G2C, MAPK3, PLA2G4A, MAPKAPK2, PRKCG, VEGFA, MAPK1, PLA2G4B, MAPK11, PXN",0.069050968832477,0,FALSE
+"H2126","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.28025,0.814,0.733,4398,1,"ATP6V1B1, ATP6V0A4, ATP6AP1, KDELR3, PDIA4, ERO1A, TCIRG1, PLCG2, KDELR1, KDELR2, ATP6V0B, ATP6V0E2, PRKCG, SEC61A1, ATP6V1G1, ARF1, TJP2",0.134896025358872,0,FALSE
+"H2126","Input","KEGG_VIRAL_MYOCARDITIS",0.22878,0.67,0.923,2655,1,"CASP9, ITGB2, CD55, MYH14, ITGAL, CD40",0.0347982989740879,0,FALSE
+"H2126","Input","KEGG_WNT_SIGNALING_PATHWAY",0.2155,0.644,0.958,1426,1,"WNT3A, FZD10, CSNK1E, FRAT1, WNT4, WNT7B, WNT11, LRP5, FRAT2",0.0186344909214556,0,FALSE
+"H520","Input","KEGG_ABC_TRANSPORTERS",0.22153,0.619,0.958,3230,1,"ABCC5, ABCB7, ABCA7, ABCA3, ABCC2, ABCD4, ABCC8",0.0186344909214556,0,FALSE
+"H520","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.46206,1.31,0.121,3881,0.59,"ZBTB16, EIF4EBP1, TCF7, RUNX1, MAP2K1, MAP2K2, LEF1, TCF7L2, PIK3CA, BRAF, RAF1, MTOR, SOS1, PIK3CB, RPS6KB2, SOS2, PIK3R2, AKT2",0.91721462968355,0.229147988357856,FALSE
+"H520","Input","KEGG_ADHERENS_JUNCTION",-0.31888,-1.16,0.198,17653,0.643,"MET, PTPRB, SNAI2, PTPN1, SNAI1, RAC2, VCL, NECTIN2, PTPRM, IQGAP1, PTPRJ, CDC42, ACTB, ERBB2, RHOA, EGFR, INSR, TGFBR2, IGF1R, BAIAP2",0.703334809738469,0.191789027075778,FALSE
+"H520","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.26156,0.739,0.86,4366,1,"ADIPOQ, PRKCQ, PCK2, PTPN11, STK11, MAPK9, MTOR, CAMKK2, PRKAG1, NFKBIB, SLC2A1, ADIPOR1, AKT2, PRKAB2, ACACB",0.0655015487564323,0,FALSE
+"H520","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.41546,1.17,0.241,3710,0.772,"GPT2, GLUD2, GOT2, ASNS, CAD, GAD1, GLUL, PPAT, ASS1",0.617982957425132,0.112382699664264,FALSE
+"H520","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.26264,0.732,0.862,2852,1,"IGF1, KCNJ1, PIK3CA, PDPK1, SCNN1A, PIK3CB",0.0644927341752872,0,FALSE
+"H520","Input","KEGG_ALLOGRAFT_REJECTION",-0.31593,-1.1,0.279,17766,0.718,"CD40, IL12A, FAS",0.554395796726402,0.1438755557577,FALSE
+"H520","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.30686,0.857,0.7,3580,1,"PLA2G12A, FADS2, PLA2G3",0.154901959985743,0,FALSE
+"H520","Input","KEGG_ALZHEIMERS_DISEASE",0.3064,0.851,0.7,5666,1,"NDUFS5, ITPR1, NDUFS7, ADAM10, CASP7, ATP2A1, NDUFB10, COX4I1, UQCR11, SDHB, NDUFA2, NDUFA10, ATP5F1D, NAE1, LPL, NDUFA9, COX7C, ERN1, COX7A2L, NDUFA7, PPP3R1, ATP5F1C, UQCRQ, CALML5, NDUFA4L2, COX5A, NDUFAB1, GSK3B, NDUFC2, ATP5MC3, NDUFB6, APH1A, PSEN2, MME, CDK5R1, PLCB1, NDUFB7, UQCRC2, NDUFS6, NDUFA4, ATP2A2, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, CALML6, RYR3, NDUFB1, ADAM17, NDUFC1, PSEN1, UQCRB, MAPK1, ATP5F1A, NDUFV1, NDUFB5, CALML3",0.154901959985743,0,FALSE
+"H520","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.50499,1.41,0.0727,7188,0.594,"WARS2, RARS2, EARS2, SEPSECS, HARS2, FARSB, MARS2, MTFMT, CARS2, LARS2, IARS2, PARS2, FARSA, TARS2",1.13846558914096,0.226213555018806,FALSE
+"H520","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.45499,-1.63,0.0222,16174,1,"GCK, NPL, RENBP, FPGT, UGDH, UAP1, GMPPA, UXS1, CYB5R1, HEXB, CYB5R3, NAGK, GALK1, CMAS, GALE, NANP, PGM1",1.65364702554936,0,FALSE
+"H520","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.28112,0.784,0.807,1987,1,"SLC1A2, SOD1, NEFL, DERL1, MAP2K6",0.0931264652779296,0,FALSE
+"H520","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.29611,0.83,0.723,1328,1,"IFNA5, NFYC, RFXAP, NFYB, CANX, CREB1",0.140861702705469,0,FALSE
+"H520","Input","KEGG_APOPTOSIS",-0.2831,-0.99,0.436,14862,0.747,"BCL2, IRAK4, PPP3R2, TNF, CASP8, PIK3R1, PRKAR2B, PRKAR2A, NFKBIA, TNFRSF10C, IRAK3, AKT3, IKBKB, IL1A, TNFRSF1A, IL1B, NGF, BAX, ENDOD1, BID, BIRC3, TP53, PIK3CD, CASP10, TRADD, TNFRSF10D, CAPN2, FAS, IL1RAP, CAPN1, MAP3K14",0.360513510731414,0.126679398184601,FALSE
+"H520","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.17423,-0.633,0.932,13977,0.959,"ALOX15, CYP2C8, PLA2G1B, CYP4A22, CYP4F3, GGT6, GGT7, PTGS1, PTGIS, GGT5, CBR3, PTGDS, ALOX5, PTGES2, PTGS2, CYP2E1, GPX1, PTGES, EPHX2",0.0305840876460186,0.0181813928293364,FALSE
+"H520","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.36736,1.04,0.39,3744,0.831,"SMS, GLUD2, ARG2, GOT2, MAOB, PYCR1, CKB, ALDH2, ALDH9A1, PYCR2, SAT1, GLUL, ASS1, ALDH3A2",0.408935392973501,0.080398976215889,FALSE
+"H520","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.23383,-0.825,0.667,14536,0.885,"ITGA7, SGCD, ITGA10, TCF7L1, ACTN1, ITGA1, SGCA, ACTN2, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, ITGB6, GJA1, ITGB3, CACNA2D1, ITGA5, LMNA, DAG1, ITGB1, ACTB, ITGA3, CACNB3",0.175874166083451,0.0530567293021746,FALSE
+"H520","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.55198,1.53,0.0445,4712,0.7,"UGT2A1, MIOX, ALDH2, ALDH9A1, ALDH3A2, ALDH7A1",1.35163998901907,0.154901959985743,FALSE
+"H520","Input","KEGG_ASTHMA",0.64109,1.8,0.00449,55,0.886,"EPX",2.34775365899668,0.0525662781129492,FALSE
+"H520","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.62081,1.73,0.00783,438,0.351,"CTLA4, IFNA5, PRF1",2.10623823794206,0.454692883534176,FALSE
+"H520","Input","KEGG_AXON_GUIDANCE",-0.26297,-0.937,0.462,17072,0.753,"CDK5, EPHB6, SEMA3E, EFNB3, NFATC2, SLIT2, CFL1, NGEF, MET, SEMA4A, EFNB2, EFNB1, EPHA2, NRP1, NFATC1, EFNA3, SEMA7A, RAC2, ABLIM3, ITGB1, NTN4, CDC42, L1CAM, SEMA3A, EFNA1, EPHB2, EFNA5, RHOA, SEMA4B, PLXNB2, SRGAP1, SEMA3C",0.335358024443874,0.123205023799299,FALSE
+"H520","Input","KEGG_BASAL_CELL_CARCINOMA",0.39497,1.1,0.314,4056,0.874,"DVL3, AXIN2, TCF7, SHH, APC, FZD1, LEF1, WNT11, TCF7L2, FZD3, PTCH2, AXIN1, CTNNB1, FZD10, GSK3B, BMP4, WNT8B",0.503070351926785,0.058488567365597,FALSE
+"H520","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.43897,1.22,0.191,4856,0.666,"GTF2F1, TAF1, GTF2A2, TBP, TAF6L, GTF2A1, GTF2H3, TAF7, TAF2, TAF5, TAF1L, TAF9B, TAF11, GTF2IRD1",0.718966632752272,0.176525770829699,FALSE
+"H520","Input","KEGG_BASE_EXCISION_REPAIR",0.33446,0.945,0.542,6120,0.923,"MUTYH, MBD4, POLD3, TDG, LIG3, NEIL1, POLL, NTHL1, POLE, FEN1, POLE4, XRCC1, POLE3, POLD2, OGG1, NEIL3",0.266000713461613,0.0347982989740879,FALSE
+"H520","Input","KEGG_BETA_ALANINE_METABOLISM",0.5122,1.43,0.0611,5769,0.655,"SMS, ALDH2, ALDH9A1, CNDP1, HADHA, GAD1, HIBCH, ALDH3A2, ALDH7A1, AOC3, EHHADH, MLYCD, AOC2",1.21395878975745,0.183758700008217,FALSE
+"H520","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.26181,0.727,0.862,3576,1,"HACD2, PECR, HADHA, FADS2, HSD17B12, TECR",0.0644927341752872,0,FALSE
+"H520","Input","KEGG_BLADDER_CANCER",-0.2505,-0.899,0.586,17931,0.799,"CXCL8, PGF, TYMP, VEGFC, DAPK1, CDKN1A, TP53, ERBB2, EGFR",0.232102383981909,0.0974532206860086,FALSE
+"H520","Input","KEGG_BUTANOATE_METABOLISM",0.38102,1.07,0.33,5901,0.91,"OXCT2, ALDH2, PDHA1, ALDH9A1, HADH, HADHA, GAD1, L2HGDH, ALDH3A2, AACS, ALDH7A1, EHHADH, BDH1, ACAT1",0.481486060122112,0.0409586076789064,FALSE
+"H520","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.24486,0.679,0.91,4278,1,"SYK, MALT1, NFATC3, MAP2K1, MAP2K2, PIK3CA, RAF1, SOS1, PPP3R1, PIK3CB, NFKBIB, GSK3B, SOS2, PIK3R2, AKT2, RAC3, PTPN6",0.0409586076789064,0,FALSE
+"H520","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.28608,0.812,0.765,3460,1,"CACNA1E, CHRM3, HTR2C, SLC8A1, PHKB, ADCY7, ITPR1, SLC25A4, MYLK2, CHRNA7, GNAL, ATP2A1, VDAC2, GNA11, PHKA2, LTB4R2, ADRB1, VDAC1, PHKA1, ERBB4, PPP3R1, SLC25A5, PRKX, CACNA1B, ADCY1, PRKACB, PPID, CALML5",0.116338564846382,0,FALSE
+"H520","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.16116,0.449,0.998,5367,0.999,"SLC8A1, CACNA2D3, COX4I1, UQCR11, COX7C, COX7A2L, UQCRQ, COX5A, UQCRC2, ATP2A2, UQCRHL, CYC1, ATP1B3, ATP1B1, UQCRB",0.000869458712628891,0.000434511774017692,FALSE
+"H520","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.29701,0.846,0.709,1475,1,"CTLA4, SELE, NRXN3, MADCAM1, CNTN1, NRCAM, NLGN3, CADM1",0.149353764816933,0,FALSE
+"H520","Input","KEGG_CELL_CYCLE",0.44489,1.25,0.164,5198,0.688,"RAD21, GADD45G, CDC14A, ORC6, CDC23, FZR1, ORC3, STAG2, ORC2, ESPL1, TGFB2, CDC20, CCNB2, CDK1, CHEK1, MCM2, PLK1, CREBBP, BUB1B, CDKN2D, SMAD4, CDC25C, ATM, RBL1, E2F2, MAD2L1, PKMYT1, TTK, ANAPC7, STAG1, BUB3, SKP2, E2F4, ANAPC1, ORC5, ZBTB17, ORC4, CDKN2A, GSK3B, RBL2, E2F1, CDC27, BUB1, MAD2L2, MCM6, RB1, CCNH, SKP1, ATR, CDK6, SMAD2, ANAPC11, CCNA2, EP300, HDAC2, MCM3, CDC14B",0.785156151952302,0.162411561764489,FALSE
+"H520","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.20211,0.561,0.983,4667,1,"CXCL14, CCL27, XCL1, ADCY7, CXCR4, GRK6, PAK1, ELMO1, MAP2K1, GNB1, XCL2, PIK3CA, BRAF, RAF1, SOS1, TIAM1, GNG2, PIK3CB, PRKX, WAS, NFKBIB, ADCY1, PRKACB, GSK3B, GSK3A, SOS2, PIK3R2, AKT2, CXCR2, GRK2, GNG7, PTK2, PLCB1, PRKCZ, GNAI1, CRKL, GNB3",0.00744648216786438,0,FALSE
+"H520","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.31649,0.875,0.65,5613,1,"RUNX1, MAP2K1, MAP2K2, CTBP1, PIK3CA, PTPN11, TGFB2, BRAF, RAF1, CBL, SOS1, SMAD4, E2F2, PIK3CB, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, TGFBR1, RB1, CRKL, CDK6, BCL2L1, HDAC2, MAPK1, CTBP2, CRK, MYC, E2F3",0.187086643357144,0,FALSE
+"H520","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.22889,-0.768,0.744,17633,0.881,"PER1, BHLHE41",0.128427064454121,0.0550240915879521,FALSE
+"H520","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2508,0.702,0.908,5651,1,"PCK2, PDHA1, SDHB, IDH1, FH, DLAT, DLST, SUCLA2, SUCLG1",0.0419141514789149,0,FALSE
+"H520","Input","KEGG_COLORECTAL_CANCER",0.36715,1.01,0.429,4149,0.862,"AXIN2, TCF7, APC, MAP2K1, LEF1, TCF7L2, PIK3CA, TGFB2, BRAF, RAF1, MAPK9, SMAD4, AXIN1, PIK3CB, CTNNB1, BIRC5, GSK3B, APPL1, PIK3R2, AKT2, TGFBR1, RAC3",0.367542707815276,0.0644927341752872,FALSE
+"H520","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.3245,-1.17,0.222,15340,0.743,"VWF, A2M, C4A, C3AR1, CD55, C1S, C4BPB, SERPING1, CFB, PROS1, THBD, BDKRB1, CFI, SERPINA1, BDKRB2, CFH, F3, C3, PLAT, SERPINE1, F2R, PLAU, TFPI, CD59, PLAUR",0.653647025549361,0.129011186239425,FALSE
+"H520","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.4262,1.18,0.215,5408,0.757,"SMS, GOT2, CBS, MAT2A, MAT2B, APIP, DNMT3B, ADI1, DNMT3A, MTAP, AHCY, DNMT1",0.667561540084395,0.120904120499927,FALSE
+"H520","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.24216,-0.863,0.61,16314,0.816,"PDGFC, IL18R1, TNFRSF6B, IL1A, CSF2, CCL5, VEGFB, CXCR6, PDGFRB, TNFRSF11A, PDGFA, LEPR, IFNAR2, IL7, TNFSF15, TNFRSF1A, IL1B, CCL20, CSF2RA, CCL26, CD70, CXCL16, CX3CL1, BMP2, CCR10, IL7R, CCL28, IL6, TNFRSF25, INHBA, IL17RA, CXCL3, MET, IFNGR1, CXCL1, CD40, ACVR2A, TGFB3, CXCL2, CXCL8, CTF1, IL12A, TNFSF12, VEGFC, TNFSF13, TNFSF9, ACVR1, IL18, TNFRSF14, IL6R, TNFRSF10D, PLEKHO2, TGFB1, CSF1, OSMR, LIF, FAS, IL6ST, CLCF1, EGFR, IL1RAP, TGFBR2, IL4R, TNFRSF12A",0.214670164989233,0.0883098412461389,FALSE
+"H520","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.27384,-0.973,0.477,15432,0.738,"CXCL10, AIM2, POLR3H, NFKBIA, RIPK3, IKBKB, DDX58, CCL5, IL1B, IL6, CASP1, POLR1C, IRF3, TBK1, IL18, POLR3F, IKBKE",0.321481620959886,0.131943638176958,FALSE
+"H520","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.29087,-1.06,0.344,15170,0.721,"ITGA1, TNF, SGCA, TNNC1, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, ADCY4, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, ITGB6, GNAS, ITGB3, TNNI3, CACNA2D1, TGFB3, TPM1, ITGA5, LMNA, ADCY9, DAG1, ITGB1, TGFB1, TPM2, ACTB, ITGA3, CACNB3",0.46344155742847,0.142064735280571,FALSE
+"H520","Input","KEGG_DNA_REPLICATION",0.48576,1.35,0.088,6012,0.618,"RFC4, RNASEH1, DNA2, POLA1, POLD3, MCM2, RNASEH2C, MCM6, RNASEH2B, RFC1, POLE, RFC5, RPA4, FEN1, POLE4, PRIM2, MCM3, MCM7, POLE3, POLD2, RNASEH2A, RPA2, RFC3, POLA2",1.05551732784983,0.209011524911184,FALSE
+"H520","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.40979,-1.46,0.0619,18696,0.66,"ETV6, EGFR, ETS2, ETS1, SPIRE1",1.20830935097988,0.180456064458131,FALSE
+"H520","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.21311,-0.773,0.779,16067,0.891,"GSTM1, GSTM3, GSTT2, FMO4, CYP2E1, AOX1, GSTM4, MAOA, GSTO1, ALDH3B1, GSTK1, MGST3",0.108462542327436,0.0501222959631252,FALSE
+"H520","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.26675,0.752,0.836,1088,1,"UCK2, UGT2A1, CES1, GMPS",0.0777937225609836,0,FALSE
+"H520","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43593,-1.56,0.044,15170,0.674,"ITGA1, GP6, RELN, VWF, LAMC3, COL11A1, ITGA2, COL5A1, COL5A3, ITGB5, THBS2, ITGA2B, CD36, COL6A3, ITGA11, COL6A2, SDC3, ITGA4, COL3A1, LAMA1, COL1A2, LAMC2, SDC2, COL5A2, ITGAV, ITGB8, COL4A2, ITGB6, ITGB3, LAMA4, LAMB2, COL6A1, COL1A1, AGRN, LAMA3, ITGA5, TNC, COL4A1, DAG1, LAMA5, ITGB1, LAMB3, SDC4, ITGA3, HSPG2, LAMB1",1.35654732351381,0.17134010346468,FALSE
+"H520","Input","KEGG_ENDOCYTOSIS",-0.20867,-0.741,0.824,17598,0.871,"ADRB2, ARFGAP1, VPS37D, LDLRAP1, MET, FGFR2, STAM, PARD6B, ASAP3, CHMP4B, ARAP2, ACAP1, HSPA1B, ARAP3, DAB2, F2R, SMURF1, CDC42, PLD1, EHD1, RAB31, CLTCL1, EHD2, EGFR, ARAP1, ARRB1, IQSEC2, IGF1R, RAB11FIP5",0.0840727883028842,0.0599818449923368,FALSE
+"H520","Input","KEGG_ENDOMETRIAL_CANCER",0.48157,1.36,0.0918,3881,0.617,"CTNNA2, AXIN2, TCF7, APC, MAP2K1, MAP2K2, LEF1, TCF7L2, PIK3CA, PDPK1, BRAF, RAF1, CTNNA1, SOS1, AXIN1, PIK3CB, CTNNB1, GSK3B, SOS2, PIK3R2, AKT2",1.03715731879876,0.209714835966758,FALSE
+"H520","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.24316,0.675,0.923,3902,1,"PTPRZ1, ATP6V0B, PAK1, ATP6V0A2, ATP6V1E2, ADAM10, PTPN11, MAPK9, GIT1, ATP6V1G2, ATP6V0C, ATP6V1H, F11R, CXCR2",0.0347982989740879,0,FALSE
+"H520","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.30689,0.84,0.736,4593,1,"EIF4EBP1, PAK2, PAK1, MAP2K1, MAP2K7, MAP2K2, NRG3, PIK3CA, BRAF, RAF1, MAPK9, MTOR, CBL, SOS1, ERBB4, PIK3CB, RPS6KB2, NCK1, GSK3B, SOS2, PIK3R2, AKT2, PTK2, CAMK2G, MAP2K4, TGFA, CRKL",0.133122185662501,0,FALSE
+"H520","Input","KEGG_ETHER_LIPID_METABOLISM",0.31444,0.871,0.661,3580,1,"PLA2G7, CHPT1, PLA2G12A, PAFAH1B2, PAFAH2, PLA2G3",0.17979854051436,0,FALSE
+"H520","Input","KEGG_FATTY_ACID_METABOLISM",0.37333,1.05,0.381,6710,0.854,"ECI1, ACAA2, ALDH2, ALDH9A1, HADH, HADHA, ADH5, ALDH3A2, ALDH7A1, CPT1B, ADH6, ACADSB, EHHADH, CPT1A, ACAT1, ECI2, CPT2, GCDH, ACSL5, ECHS1, ADH1C",0.419075024324381,0.068542129310995,FALSE
+"H520","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.31452,0.882,0.655,4149,1,"SYK, MAP2K1, MAP2K7, MAP2K2, PIK3CA, PDPK1, MAP2K6, RAF1, MAPK9, FYN, SOS1, PLA2G12A, PIK3CB, PLA2G3, SOS2, PIK3R2, AKT2, RAC3",0.183758700008217,0,FALSE
+"H520","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.21642,-0.818,0.785,17280,0.881,"PLCG2, ARPC5, CFL1, VAV3, PLPP1, PRKCA, ARPC1B, VAV2, ASAP3, PLPP3, ARPC2, GSN, RAC2, PIK3CD, CDC42, PLD1, SPHK1, PRKCD, VASP",0.105130343254747,0.0550240915879521,FALSE
+"H520","Input","KEGG_FOCAL_ADHESION",-0.34036,-1.16,0.242,15230,0.643,"PIK3R1, ACTN2, RELN, VWF, LAMC3, FLT4, PDGFRA, COL11A1, ITGA2, COL5A1, COL5A3, MYLK, ITGB5, THBS2, ITGA2B, COL6A3, ITGA11, CCND2, PRKCG, AKT3, COL6A2, PDGFC, ACTG1, VEGFB, ITGA4, COL3A1, PDGFRB, PDGFA, LAMA1, BCAR1, COL1A2, LAMC2, RAP1B, COL5A2, ITGAV, ITGB8, COL4A2, ITGB6, ITGB3, LAMA4, CCND3, LAMB2, VAV3, MET, COL6A1, PRKCA, DOCK1, COL1A1, FLNC, RAP1A, PGF, VAV2, LAMA3, VEGFC, SHC1, BIRC3, ITGA5, MYL12A, TNC, ILK, COL4A1, MYL9, RAC2, VCL, LAMA5, FLNA, PIK3CD, ITGB1, MYL12B, PARVA, CDC42, LAMB3, CAPN2, ACTB, ERBB2, CAV2, RHOA, EGFR, CAV1, ITGA3, PXN, FLNB, IGF1R, LAMB1, VASP, ZYX",0.616184634019569,0.191789027075778,FALSE
+"H520","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.27945,-1,0.409,15141,0.775,"ALPG, ALPL, ALPP, QDPR, SPR, FPGS",0.388276691992658,0.11069829749369,FALSE
+"H520","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.22115,-0.779,0.789,16567,0.901,"FPGT, PFKFB4, MTMR6, PFKL, PHPT1, GMPPA, PFKFB2, PFKP",0.10292299679058,0.045275209020937,FALSE
+"H520","Input","KEGG_GALACTOSE_METABOLISM",-0.38693,-1.38,0.0941,17740,0.657,"GLB1, B4GALT1, GALK1, GALE, PFKP, PGM1",1.02641037657274,0.182434630440219,FALSE
+"H520","Input","KEGG_GAP_JUNCTION",0.32333,0.898,0.627,3267,0.985,"HTR2C, TUBB2B, MAP2K5, ADCY7, ITPR1, MAP2K1, TUBB2A, MAP2K2, MAP3K2, GNA11, CDK1, RAF1, ADRB1, PRKG2, SOS1, PRKX, ADCY1, PRKACB",0.202732459169284,0.00656376950238827,FALSE
+"H520","Input","KEGG_GLIOMA",0.31251,0.865,0.668,6125,1,"IGF1, MAP2K1, MAP2K2, PIK3CA, BRAF, RAF1, MTOR, SOS1, E2F2, PIK3CB, CALML5, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, RB1, CAMK2G, TGFA, CDK6, CALML6, EGF, MAPK1, E2F3, CALML3, CAMK2A, CALM3, PIK3R3",0.175223537524454,0,FALSE
+"H520","Input","KEGG_GLUTATHIONE_METABOLISM",0.24475,0.683,0.917,2025,1,"SMS, GPX2, GSTA4, GCLC, TXNDC12, IDH1",0.0376306643299789,0,FALSE
+"H520","Input","KEGG_GLYCEROLIPID_METABOLISM",0.40483,1.14,0.268,2416,0.788,"AKR1A1, LIPC, LCLAT1, DGKQ, DGKG, ALDH2, AGPAT4, GK, ALDH9A1, LPL",0.571865205971211,0.103473782510445,FALSE
+"H520","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.23019,-0.788,0.7,17148,0.903,"DGKH, LCAT, ACHE, AGPAT3, PISD, GPD2, PLPP1, LYPLA2, PCYT2, PLPP3, MBOAT7, AGPAT2, PLD1, DGKA, GPD1L",0.154901959985743,0.0443122496864942,FALSE
+"H520","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.46351,1.29,0.138,2770,0.607,"PIPOX, PSPH, PHGDH, SHMT2, MAOB, CBS, CHDH, PSAT1",0.860120913598763,0.216811308924742,FALSE
+"H520","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.22013,0.617,0.952,4876,1,"AKR1A1, PCK2, ALDH3A1, ALDH2, PDHA1, ALDH9A1, HK2, ADH5, ALDH3A2, DLAT, ENO3, ALDOB, ALDH7A1, ADH6",0.0213630516155257,0,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.23729,-0.813,0.67,16826,0.871,"XYLT1, CHST11, UST, CHST3, CHPF2",0.173925197299174,0.0599818449923368,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.26186,0.733,0.859,3513,1,"NDST2, B3GAT3, HS6ST1, GLCE, HS2ST1",0.0660068361687577,0,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.34902,-1.25,0.17,17016,0.7,"B3GNT7, ST3GAL1, B4GAT1, B3GNT2, FUT8, B4GALT1",0.769551078621726,0.154901959985743,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.28559,-0.993,0.419,12993,0.766,"NAGLU, HEXA, GUSB, HYAL4, SGSH, HYAL2, IDS, HGSNAT, HPSE, GLB1, HEXB, GNS, GALNS",0.377785977033705,0.115771230367396,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.51121,-1.94,0,16108,0.62,"ST3GAL5, ST8SIA1, ST3GAL1, GLB1, HEXB, ST6GALNAC4, ST6GALNAC6",Inf,0.207608310501746,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.30192,-1.11,0.278,16360,0.73,"ST8SIA1, B3GALT5, GBGT1, ST3GAL1, NAGA, HEXB",0.555955204081924,0.136677139879544,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.50207,1.4,0.0684,2431,0.526,"B3GALT2, FUT1, B4GALT2, ST3GAL3, FUT7, FUT4, FUT9",1.16494389827988,0.279014255846261,FALSE
+"H520","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.50654,1.41,0.0675,5032,0.594,"PIGM, PIGX, PIGG, PIGQ, PIGH, PIGS, PIGA, PIGP, PIGN, PIGO, PGAP1, PIGV, PIGW",1.17069622716898,0.226213555018806,FALSE
+"H520","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.61907,1.74,0.00899,4790,0.436,"HAO2, MTHFD2, PGP, MTHFD1L, AFMID, MTHFD2L, HYI, GRHPR",2.04624030826677,0.360513510731414,FALSE
+"H520","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.26844,0.755,0.841,4479,1,"ADCY7, ITPR1, MAP2K1, ATF4, MAP2K7, MAP2K2, MAP3K4, MAP3K2, GNA11, MAP2K6, RAF1, MAPK9, SOS1, PLA2G12A, PRKX, ADCY1, PRKACB, CALML5, PLA2G3, SOS2, PLCB1, CAMK2G, MAP2K4",0.0752040042020878,0,FALSE
+"H520","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.26891,0.761,0.821,438,1,"PRF1",0.0856568428805592,0,FALSE
+"H520","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.34723,0.973,0.495,5660,0.912,"BMP8A, SHH, CSNK1G3, BMP8B, WNT11, CSNK1G2, PTCH2, BMP7, CSNK1G1, PRKX, PRKACB, GSK3B, BMP4, WNT8B, FBXW11, RAB23, PRKACA, WNT5A, PTCH1, STK36, CSNK1E",0.305394801066431,0.0400051616715838,FALSE
+"H520","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.29731,-1.06,0.312,15170,0.721,"ITGA1, TNF, CD1D, CSF1R, ITGA2, ITGAM, FCGR1A, CD55, ITGA2B, CD22, CD36, IL1A, CSF2, ANPEP, ITGA4, IL7, CD9, IL1B, CSF2RA, CD37, IL7R, IL6, ITGB3, ITGA5, IL6R, CD59, CSF1, ITGA3, IL4R",0.505845405981557,0.142064735280571,FALSE
+"H520","Input","KEGG_HISTIDINE_METABOLISM",0.43296,1.22,0.188,2218,0.666,"LCMT1, MAOB, ALDH3A1, ALDH2, ALDH9A1, LCMT2, CNDP1",0.72584215073632,0.176525770829699,FALSE
+"H520","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.50465,1.41,0.0588,5713,0.594,"POLD3, MUS81, RAD51C, RAD54B, RAD51B, RAD51, EME1, RAD50, BLM, XRCC2, RAD54L, RAD52, MRE11, RPA4, XRCC3, BRCA2, POLD2, RPA2",1.23062267392386,0.226213555018806,FALSE
+"H520","Input","KEGG_HUNTINGTONS_DISEASE",0.3802,1.06,0.361,5916,0.88,"UCP1, NDUFS5, SOD1, ITPR1, SLC25A4, POLR2D, AP2B1, NDUFS7, POLR2G, CREB1, NDUFB10, POLR2H, COX4I1, UQCR11, NRF1, SDHB, NDUFA2, SP1, TBP, VDAC2, TFAM, NDUFA10, VDAC1, POLR2C, CREBBP, ATP5F1D, DCTN4, NDUFA9, POLR2E, COX7C, COX7A2L, NDUFA7, SIN3A, SLC25A5, ATP5F1C, UQCRQ, PPID, AP2M1, NDUFA4L2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, POLR2J, PLCB1, NDUFB7, CREB3L4, UQCRC2, NDUFS6, POLR2K, NDUFA4, NDUFS3, REST, NDUFA1, UQCRHL, NDUFB9, CYC1, EP300, HDAC2, NDUFB1, NDUFC1, UQCRB, ATP5F1A, DNAH1, NDUFV1, NDUFB5, AP2A2, CREB3, DCTN1, POLR2I, HAP1, HIP1, TBPL1",0.442492798094342,0.0555173278498314,FALSE
+"H520","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34828,-1.27,0.144,14536,0.709,"ITGA7, SGCD, ITGA10, TNNT2, ACE, ITGA1, TNF, SGCA, TNNC1, CACNG7, DES, ITGA2, ITGB5, CACNA2D4, ITGA2B, ITGA11, CACNA1C, CACNG6, ACTG1, CACNG4, ITGA4, CACNG8, ITGAV, ITGB8, IL6, ITGB6, ITGB3, TNNI3, CACNA2D1, TGFB3, TPM1, ITGA5, LMNA, DAG1, ITGB1, TGFB1, TPM2, ACTB, ITGA3, CACNB3, PRKAG2",0.84163750790475,0.149353764816933,FALSE
+"H520","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.29103,0.818,0.762,5884,1,"PIP4K2B, MIOX, PIK3CA, OCRL, INPPL1, PIK3CB, PIKFYVE, PIK3C3, CDIPT, INPP5J, PLCD4, PIK3C2A, ITPKB, PLCB1, ALDH6A1, IMPA1, PIK3C2B, PI4KB, PIP5K1A, INPP5B, PIP5K1C, INPP5E, IPMK, INPP4A",0.1180450286604,0,FALSE
+"H520","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.36694,1.02,0.418,4093,0.844,"EIF4EBP1, PHKB, PPP1R3B, MKNK2, MAP2K1, MAP2K2, SOCS4, SORBS1, PCK2, TSC2, PYGM, PIK3CA, PPP1CC, PDPK1, FLOT2, ACACA, BRAF, PHKA2, EIF4E, RAF1, MAPK9, MTOR, PHKA1, CBL, SOS1, EIF4E2, PIK3CB, PRKX, PRKAG1, HK2, PRKACB, RPS6KB2, PDE3B, CALML5, RPS6, SOCS1, PPP1CB, GSK3B, SOS2, PIK3R2, AKT2, PRKAB2, PHKG2",0.378823718224965,0.073657553374345,FALSE
+"H520","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.33611,0.929,0.578,597,0.946,"CCL27, MADCAM1, CXCR4",0.238072161579471,0.0241088635982073,FALSE
+"H520","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.20307,-0.712,0.926,16023,0.896,"IL13RA2, CCND2, AKT3, IL15, STAM2, CSF2, JAK3, CBLC, LEPR, IFNAR2, IL7, CSF2RA, SOCS2, STAT4, IL7R, IL6, CCND3, IFNGR1, STAT5A, STAM, CTF1, IL12A, PIAS3, JAK1, SPRY1, STAT5B, CISH, PIK3CD, IL6R, OSMR, LIF, IL6ST, CLCF1, SOCS3, IL4R, STAT6",0.0333890133180656,0.0476919903378748,FALSE
+"H520","Input","KEGG_LEISHMANIA_INFECTION",-0.36403,-1.35,0.0816,15651,0.646,"ITGAM, STAT1, NFKBIA, FCGR1A, FOS, FCGR2A, IL1A, ITGA4, TLR4, NCF2, IL1B, PTGS2, ITGB2, IFNGR1, MAPK11, TGFB3, C3, IL12A, JAK1, ITGB1, TGFB1",1.08830984124614,0.189767482004916,FALSE
+"H520","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.35323,-1.3,0.155,14879,0.697,"CLDN4, CLDN14, ACTN1, CDH5, VCAM1, CLDN22, PIK3R1, ACTN2, MMP9, CYBB, JAM2, CLDN16, CXCL12, ITGAM, EZR, PRKCG, ESAM, ACTG1, ITGA4, BCAR1, NCF2, THY1, RAPGEF3, RAP1B, CLDN9, ITGB2, PLCG2, RASSF5, SIPA1, VAV3, PRKCA, MAPK11, PTK2B, RAP1A, VAV2, MYL12A, MYL9, RAC2, VCL, CLDN1, ICAM1, PIK3CD, ITGB1, MYL12B, CDC42, ACTB, RHOA, PXN, VASP, CD99",0.809668301829709,0.156767221901991,FALSE
+"H520","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.63758,1.78,0.00887,5612,0.512,"ALDH2, ALDH9A1, HADHA, ALDH3A2, ALDH7A1, EHHADH, YOD1, NAA80",2.05207638016827,0.290730039024169,FALSE
+"H520","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.16716,0.47,0.998,14427,1,"PLA2G12A, PLA2G3, CYP3A4, PLA2G6, CYP3A7, PLA2G4B, PLA2G4E, CYP2J2, PLA2G10, PLA2G4A, CYP2C9, PLA2G2E, PLA2G2D, PLA2G2A, CYP2C18, PLA2G12B, CYP1A2, CYP3A43, PLA2G5, PLA2G2C, PLA2G2F, CYP3A5, CYP2C19, ALOX15, CYP2C8, PLA2G1B, AKR1B10",0.000869458712628891,0,FALSE
+"H520","Input","KEGG_LONG_TERM_DEPRESSION",0.38407,1.09,0.325,2535,0.892,"IGF1, ITPR1, PPP2CA, MAP2K1, MAP2K2, BRAF, GNA11, RAF1, PRKG2, PPP2R1B, PLA2G12A",0.488116639021126,0.0496351456238769,FALSE
+"H520","Input","KEGG_LONG_TERM_POTENTIATION",0.34937,0.962,0.511,6008,0.897,"ITPR1, MAP2K1, ATF4, MAP2K2, RPS6KA6, PPP1CC, BRAF, RAF1, CREBBP, PPP3R1, RPS6KA2, PRKX, ADCY1, PRKACB, CALML5, PPP1CB, PLCB1, CAMK2G, PRKACA, CALML6, EP300, MAPK1, CALML3, CAMK2A, CALM3",0.291579099865287,0.0472075569559079,FALSE
+"H520","Input","KEGG_LYSINE_DEGRADATION",0.54166,1.49,0.048,6899,0.608,"PIPOX, NSD3, KMT5A, NSD2, DOT1L, NSD1, ALDH2, SETD1A, ALDH9A1, HADH, HADHA, SETDB1, SETD1B, ALDH3A2, SUV39H2, ALDH7A1, DLST, EHHADH, KMT5C, ASH1L, ACAT1, SETDB2, AASDH, GCDH, KMT5B, PLOD3, EHMT2, ECHS1, EHMT1, SUV39H1",1.31875876262441,0.216096420727265,FALSE
+"H520","Input","KEGG_LYSOSOME",-0.3038,-1.09,0.315,16611,0.707,"NAGPA, AP3B1, PLA2G15, LAMP1, SUMF1, ACP5, SLC11A1, M6PR, AP1S3, LAPTM4A, CLN5, GM2A, CTSV, NAGA, SMPD1, CTSL, LGMN, GLB1, HEXB, GNS, CTSS, CTSH, TPP1, NEU1, GALNS, FUCA1, NPC2, AP1S1, ABCA2, CTSB, CTSD, CD68, CD63, CLTCL1, CTSA, LIPA, TCIRG1",0.501689446210399,0.150580586203101,FALSE
+"H520","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.30889,0.858,0.678,3881,1,"CACNA1E, FGF3, FGF19, FGF4, FGF21, CACNA2D3, MAP2K5, FGF20, TAOK1, GADD45G, PAK2, FGF9, PAK1, MKNK2, MAP2K1, FGFR1, NLK, ATF4, MAP2K7, MAP2K2, MAP3K13, RPS6KA6, ATF2, TGFB2, BRAF, MAP3K4, MAP3K2, DUSP16, MAPKAPK5, MAP2K6, RAF1, MAPK8IP3, MAPK9, IL1R2, ECSIT, SOS1, MAP3K7, FGFR3, PLA2G12A, DUSP14, DUSP6, PPP3R1, MAP4K3, NF1, RPS6KA2, PRKX, CACNA1B, PRKACB, FGF22, FGF13, TAOK2, PLA2G3, MAP4K1, HSPA1L, MAP4K2, SOS2, AKT2",0.168770306132937,0,FALSE
+"H520","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.38264,1.06,0.371,445,0.88,"FOXA2, ONECUT1",0.430626090384954,0.0555173278498314,FALSE
+"H520","Input","KEGG_MELANOGENESIS",0.36435,1,0.459,6351,0.869,"KITLG, DVL3, TCF7, ADCY7, FZD1, MAP2K1, MAP2K2, LEF1, WNT11, CREB1, TCF7L2, MC1R, RAF1, FZD3, CREBBP, DCT, CTNNB1, PRKX, ADCY1, PRKACB, FZD10, CALML5, GSK3B, WNT8B, PLCB1, CAMK2G, GNAI1, CREB3L4, PRKACA, WNT5A, CALML6, EP300, MAPK1, CALML3, CREB3, CAMK2A, CALM3, FZD8, FZD6, WNT16, WNT2B, DVL1",0.338187314462739,0.0609802235513335,FALSE
+"H520","Input","KEGG_MELANOMA",0.48653,1.34,0.101,3954,0.593,"FGF3, FGF19, FGF4, IGF1, FGF21, FGF20, FGF9, MAP2K1, FGFR1, MAP2K2, PIK3CA, BRAF, RAF1, E2F2, PIK3CB, FGF22, FGF13, CDKN2A, PIK3R2, AKT2, E2F1",0.995678626217357,0.226945306635737,FALSE
+"H520","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.23149,0.644,0.942,3224,1,"UGT2A1, AKR1C1, AKR1C2, ALDH3A1, GSTA4, AKR1C3, CYP1A1, EPHX1, ADH5",0.0259490972071227,0,FALSE
+"H520","Input","KEGG_MISMATCH_REPAIR",0.37097,1.02,0.419,7112,0.844,"RFC4, POLD3, EXO1, RFC1, PMS2, RFC5, RPA4, MSH6, POLD2, RPA2, RFC3, RPA3, MSH2, RFC2",0.377785977033705,0.073657553374345,FALSE
+"H520","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.53531,1.49,0.043,3881,0.608,"IGF1, EIF4EBP1, RPS6KA6, TSC2, PIK3CA, PDPK1, BRAF, STK11, MLST8, EIF4E, ULK1, MTOR, DDIT4, EIF4E2, PIK3CB, ULK3, RPS6KA2, VEGFA, RPS6KB2, RPS6, PIK3R2, EIF4B, AKT2",1.36653154442041,0.216096420727265,FALSE
+"H520","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.25675,0.715,0.882,2852,1,"IFNA5, SYK, PRF1, PAK1, NFATC3, MAP2K1, ULBP1, MAP2K2, PIK3CA, PTPN11, BRAF, IFNAR1, RAF1, FYN, SOS1, PPP3R1, PIK3CB",0.0545314148681803,0,FALSE
+"H520","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.39605,1.11,0.299,2107,0.857,"GPR50, GRM8, GRIK3, GPR83, GRM3, NMUR2, CHRM3, OPRD1, GABRA3, PTH2R, ADRA2C, HTR2C, GABRR2, LPAR6, SCTR, GABRG2, MCHR2, GABRR1, CHRNA7, P2RY11, GALR2, PTGER4, GABRQ, GALR3, LTB4R2, MC1R, LTB4R, P2RY14, ADRB1",0.52432881167557,0.0670191780768018,FALSE
+"H520","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.21165,0.591,0.972,5375,1,"MAP2K5, SH2B1, MAP2K1, ATF4, MAP2K7, MAP2K2, RPS6KA6, PIK3CA, PTPN11, PDPK1, BRAF, RAF1, MAPK9, SOS1, PIK3CB, RPS6KA2, RIPK2, NFKBIB, CALML5, GSK3B, SOS2, PIK3R2, AKT2, CAMK2G, PRDM4, IRAK1, CRKL, NTRK2, BEX3, FASLG, CALML6, TP73, PSEN1, MAPK1",0.0123337350737254,0,FALSE
+"H520","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.27808,-0.955,0.419,15820,0.732,"NT5M, PNP, BST1, NAMPT, NT5C2, AOX1, ENPP1, QPRT, NMNAT2, NNMT, NT5E",0.377785977033705,0.135488918941608,FALSE
+"H520","Input","KEGG_NITROGEN_METABOLISM",0.56754,1.57,0.0294,1340,0.652,"CA6, CA7, GLUD2, CA8, ASNS",1.53165266958784,0.18575240426808,FALSE
+"H520","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29362,-1.02,0.462,16189,0.787,"NLRP3, NOD1, IKBKB, CCL5, IL1B, TNFAIP3, TAB3, IL6, CXCL1, MAPK11, CXCL2, CASP1, CXCL8, BIRC3, CARD6, IL18, NLRP1, TRIP6",0.335358024443874,0.104025267640935,FALSE
+"H520","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.46733,1.31,0.116,7316,0.59,"XRCC5, RAD50, POLL, DNTT, MRE11, FEN1, LIG4, DCLRE1C, NHEJ1, XRCC6",0.935542010773082,0.229147988357856,FALSE
+"H520","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26708,0.75,0.838,5613,1,"MAP2K1, MAP2K2, PIK3CA, PDPK1, BRAF, RAF1, SOS1, E2F2, PIK3CB, CDKN2A, SOS2, PIK3R2, AKT2, E2F1, RB1, TGFA, CDK6, EGF, MAPK1, E2F3",0.0767559813697235,0,FALSE
+"H520","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.37491,1.05,0.375,5494,0.854,"DVL3, MAML1, MAML2, CTBP1, LFNG, CREBBP, CIR1, RFNG, APH1A, PSEN2, DTX3, MAML3, KAT2A, EP300, HDAC2, ADAM17, PSEN1, SNW1, CTBP2",0.425968732272281,0.068542129310995,FALSE
+"H520","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.33699,0.917,0.606,5873,0.956,"RFC4, POLD3, ERCC4, RAD23A, GTF2H3, ERCC3, CUL4B, RFC1, CCNH, POLE, RFC5, RPA4, POLE4, XPC, DDB2, POLE3, POLD2, RPA2, DDB1, RFC3",0.217527375833714,0.0195421077238999,FALSE
+"H520","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.38059,1.06,0.37,6489,0.88,"MGAT5, MAN1A1, MAN2A1, B4GALT2, ALG3, RPN1, ST6GAL1, MOGS, ALG9, ALG13, STT3B, MAN2A2, B4GALT3, RPN2, ALG1, GANAB, DOLPP1, ALG10B, MGAT4A, ALG5, ALG12, RFT1, MAN1C1, MGAT4B, STT3A",0.431798275933005,0.0555173278498314,FALSE
+"H520","Input","KEGG_OLFACTORY_TRANSDUCTION",0.37001,1.04,0.407,1297,0.831,"OR10S1, OR6T1, OR4D5, OR2B3, OR6B2, OR5M11, OR10AD1, OR11H6, OR8S1, OR10AG1, OR13J1, GNAL, OR1J1",0.39040559077478,0.080398976215889,FALSE
+"H520","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.56465,1.58,0.0174,6339,0.736,"MTHFD2, SHMT2, ALDH1L1, GART, MTHFD1L, MTHFD2L, MTHFR, MTFMT, FTCD, DHFR, MTHFS",1.7594507517174,0.133122185662501,FALSE
+"H520","Input","KEGG_OOCYTE_MEIOSIS",0.41586,1.15,0.26,5042,0.807,"IGF1, ADCY7, ITPR1, PPP2CA, MAP2K1, CDC23, RPS6KA6, PPP1CC, ESPL1, CDC20, CCNB2, CDK1, PLK1, PPP2R1B, CDC25C, STAG3, PPP3R1, MAD2L1, PKMYT1, RPS6KA2, PRKX, ANAPC7, ADCY1, PRKACB, ANAPC1, PPP2R5E, CALML5, SGO1, PPP1CB, CDC27, BUB1, AR, MAD2L2, CAMK2G, FBXW11, PPP2R5D, SKP1, ANAPC11, PRKACA, CALML6",0.585026652029182,0.0931264652779296,FALSE
+"H520","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.46682,-1.59,0.0392,17370,0.794,"MAN2B2, GLB1, HEXB, NEU1, FUCA1",1.40671393297954,0.100179497572904,FALSE
+"H520","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.40796,1.15,0.266,5601,0.807,"ATP4A, NDUFS5, ATP6V0B, ATP5ME, ATP6V0A2, ATP6V1E2, NDUFS7, NDUFB10, PPA1, COX4I1, COX11, UQCR11, SDHB, NDUFA2, NDUFA10, ATP5F1D, NDUFA11, NDUFA9, COX7C, COX7A2L, NDUFA7, ATP6V1G2, ATP5F1C, ATP6V0C, UQCRQ, ATP6V1H, NDUFA4L2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, NDUFB7, UQCRC2, NDUFS6, NDUFA4, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, ATP6V0E2, ATP6V0A1, NDUFB1, NDUFC1, UQCRB, ATP6V1A, ATP5F1A, NDUFV1, NDUFB5",0.575118363368933,0.0931264652779296,FALSE
+"H520","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.38591,1.08,0.338,1096,0.911,"GALNT10, GALNT13, GCNT1, GALNT6",0.471083299722345,0.0404816230270017,FALSE
+"H520","Input","KEGG_P53_SIGNALING_PATHWAY",0.29023,0.805,0.765,2571,1,"IGF1, GADD45G, SESN2, SIAH1, RPRM, COP1, TSC2, CCNB2, CDK1, TP53AIP1, CHEK1, CCNG1, ATM",0.116338564846382,0,FALSE
+"H520","Input","KEGG_PANCREATIC_CANCER",-0.29123,-0.97,0.422,17729,0.719,"RALBP1, RALGDS, TGFB3, PGF, VEGFC, JAK1, RAC2, TP53, PIK3CD, CDC42, PLD1, TGFB1, ERBB2, EGFR, TGFBR2, RALB",0.374687549038326,0.143271109617117,FALSE
+"H520","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.28974,0.807,0.769,6096,1,"PANK3, PPCDC, COASY, PPCS, PANK4, PANK1, PANK2",0.114073660198569,0,FALSE
+"H520","Input","KEGG_PARKINSONS_DISEASE",0.40031,1.13,0.279,6850,0.805,"NDUFS5, SLC18A2, SLC25A4, NDUFS7, NDUFB10, COX4I1, UQCR11, SDHB, NDUFA2, VDAC2, NDUFA10, VDAC1, ATP5F1D, NDUFA9, COX7C, COX7A2L, NDUFA7, SLC25A5, ATP5F1C, UQCRQ, PPID, UCHL1, NDUFA4L2, UBE2J2, COX5A, NDUFAB1, NDUFC2, ATP5MC3, NDUFB6, NDUFB7, UQCRC2, PARK7, NDUFS6, NDUFA4, NDUFS3, NDUFA1, UQCRHL, NDUFB9, CYC1, NDUFB1, NDUFC1, UQCRB, ATP5F1A, NDUFV1, NDUFB5, UBE2J1, UBE2L6, PINK1, CASP9, UQCRFS1, COX8A, NDUFS1, NDUFA6, CASP3, COX6A1, SNCA, COX7B, ATP5MC2",0.554395796726402,0.0942041196321315,FALSE
+"H520","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.32967,-1.16,0.238,16265,0.643,"TUBB8, ACTG1, TLR4, TUBB4B, TLR5, TUBB, ARPC5, PRKCA, ARPC1B, ARPC2, CLDN1, ITGB1, CDC42, TUBB6, ACTB, RHOA, TUBA4A",0.623423042943488,0.191789027075778,FALSE
+"H520","Input","KEGG_PATHWAYS_IN_CANCER",0.28208,0.787,0.797,4222,1,"FGF3, FGF19, FGF4, IGF1, ZBTB16, FGF21, KITLG, CTNNA2, DVL3, AXIN2, TCF7, FGF20, SHH, FGF9, APC, FZD1, RUNX1, MAP2K1, FGFR1, DAPK2, MAP2K2, LEF1, VHL, WNT11, CTBP1, TCF7L2, LAMC1, PIK3CA, TGFB2, BRAF, RAF1, FZD3, PIAS4, MAPK9, CREBBP, PTCH2, MTOR, CTNNA1, EGLN2, CBL, SOS1, SMAD4, FGFR3, XIAP, EGLN1, E2F2, AXIN1, PIK3CB, CTNNB1, RAD51, ELOB, FH, VEGFA, SKP2, FGF22, TRAF4, SLC2A1, FZD10, FGF13, CKS1B, BIRC5, ARNT, ARNT2, CDKN2A, GSK3B, APPL1, SOS2, PIK3R2, AKT2, TPR, BMP4, E2F1, EPAS1, TGFBR1, WNT8B, AR, RAC3, RB1, PTK2",0.0985416786038876,0,FALSE
+"H520","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.25667,0.718,0.865,2705,1,"UGT2A1, DCXR",0.0629838925351858,0,FALSE
+"H520","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.323,-1.17,0.248,18666,0.743,"DERA, PFKP, PGM1",0.605548319173784,0.129011186239425,FALSE
+"H520","Input","KEGG_PEROXISOME",0.35016,0.974,0.482,2893,0.921,"HAO2, PIPOX, PRDX1, SOD1, MPV17L, PEX12, PEX2, IDH1, PECR, SLC27A2, PEX14, PEX5, PEX11G, ABCD4, PEX16",0.31695296176115,0.0357403698031511,FALSE
+"H520","Input","KEGG_PHENYLALANINE_METABOLISM",0.50311,1.4,0.075,1326,0.526,"PAH, GOT2, MAOB, ALDH3A1",1.1249387366083,0.279014255846261,FALSE
+"H520","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.27782,0.782,0.81,6125,1,"DGKQ, ITPR1, PIP4K2B, DGKG, PIK3CA, OCRL, INPPL1, PIK3CB, PIKFYVE, PIK3C3, CDIPT, CALML5, INPP5J, PLCD4, PIK3C2A, PIK3R2, ITPKB, PLCB1, IMPA1, DGKE, PIK3C2B, PI4KB, CALML6, PIP5K1A, INPP5B, CDS1, PIP5K1C, CALML3, INPP5E, INPP4A, CALM3, PIK3R3",0.0915149811213502,0,FALSE
+"H520","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.40398,1.14,0.273,2577,0.788,"UROD, UGT2A1, EARS2, FECH, HMBS",0.563837352959244,0.103473782510445,FALSE
+"H520","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.32613,0.902,0.613,3610,0.985,"ADIPOQ, UCP1, SORBS1, PCK2, PDPK1, GK, ME1, LPL, SLC27A2, FADS2, NR1H3, SLC27A5",0.212539525481585,0.00656376950238827,FALSE
+"H520","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.27586,-1,0.382,17295,0.775,"ACOX2, CYP39A1, SCP2",0.417936637088291,0.11069829749369,FALSE
+"H520","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.19981,0.554,0.981,4361,1,"RFXAP, TNFRSF13C, RAG1, RFX5, IGLL1, CD8A",0.0083309926200515,0,FALSE
+"H520","Input","KEGG_PRION_DISEASES",0.35537,1,0.467,5375,0.869,"SOD1, MAP2K1, MAP2K2, LAMC1, FYN, PRKX, PRKACB, NCAM1, STIP1, PRKACA, MAPK1",0.330683119433888,0.0609802235513335,FALSE
+"H520","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.43344,1.22,0.181,4986,0.666,"IGF1, ADCY7, MAP2K1, CDC23, FZR1, RPS6KA6, PIK3CA, BRAF, CCNB2, CDK1, RAF1, PLK1, MAPK9, CDC25C, MAD2L1, PKMYT1, PIK3CB, RPS6KA2, PRKX, ANAPC7, ADCY1, PRKACB, ANAPC1, PDE3B, PIK3R2, AKT2, CDC27, BUB1, MAD2L2, GNAI1, ANAPC11, PRKACA, CCNA2",0.742321425130815,0.176525770829699,FALSE
+"H520","Input","KEGG_PROPANOATE_METABOLISM",0.44919,1.25,0.152,5901,0.688,"ACSS3, ALDH2, ACACA, ALDH9A1, HADHA, HIBCH, ALDH3A2, ACACB, ALDH6A1, ALDH7A1, PCCB, EHHADH, MLYCD, SUCLA2, SUCLG1, MCEE, ACAT1",0.818156412055227,0.162411561764489,FALSE
+"H520","Input","KEGG_PROSTATE_CANCER",0.3433,0.965,0.501,4584,0.911,"IGF1, TCF7, MAP2K1, FGFR1, ATF4, MAP2K2, LEF1, CREB1, TCF7L2, PIK3CA, PDPK1, BRAF, RAF1, CREBBP, MTOR, SOS1, E2F2, PIK3CB, CTNNB1, GSK3B, SOS2, PIK3R2, AKT2, E2F1, AR, RB1, CREB3L4, TGFA",0.300162274132754,0.0404816230270017,FALSE
+"H520","Input","KEGG_PROTEASOME",0.28788,0.794,0.796,7640,1,"PSMD7, PSMD2, PSMB11, PSMD11, PSMD14, PSME4, PSMC3, PSME3, PSMD8, PSMA3, PSMA4, PSMD1, PSMC5, PSMB1, PSME2, PSMC6, PSMD3, PSMD6, PSMD4, PSMA2, PSMC2, PSMC1",0.0990869322623309,0,FALSE
+"H520","Input","KEGG_PROTEIN_EXPORT",0.46945,1.34,0.11,3508,0.593,"SRPRB, IMMP1L, SRP19, SEC63, SEC61A1, SEC11A, SRP9, SEC62, SEC11C",0.958607314841775,0.226945306635737,FALSE
+"H520","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.37818,1.04,0.411,1596,0.831,"GLUD2, PCK2, SLC25A10",0.386158178123931,0.080398976215889,FALSE
+"H520","Input","KEGG_PURINE_METABOLISM",0.34935,0.968,0.509,4730,0.915,"PDE8B, ENTPD8, ENTPD3, ENTPD1, PDE6B, ADCY7, PAPSS1, POLR2D, ALLC, GMPS, POLR3A, POLR2G, PDE4D, POLA1, POLD3, PDE5A, POLR2H, GART, NUDT2, PDE7A, POLR2C, POLR2E, RRM1, PRUNE1, PRPS2, ADCY1, NPR2, PDE3B, PPAT, POLR1E, POLR3G, GMPR, NME2, PAICS, NT5C3A, POLR2J, APRT, POLR1D, PDE11A, PRPS1, ADK, POLE, NT5C, POLR2K",0.293282217663241,0.0385789059335517,FALSE
+"H520","Input","KEGG_PYRIMIDINE_METABOLISM",0.32743,0.918,0.594,4135,0.965,"ENTPD8, ENTPD3, ENTPD1, UCK2, POLR2D, POLR3A, POLR2G, DUT, POLA1, POLD3, POLR2H, CTPS1, NUDT2, CTPS2, POLR2C, DTYMK, POLR2E, RRM1, CAD, DHODH, UMPS, POLR1E, UCK1, POLR3G, NME2, NT5C3A, POLR2J, POLR1D",0.226213555018806,0.0154726866562074,FALSE
+"H520","Input","KEGG_PYRUVATE_METABOLISM",0.37537,1.05,0.362,4790,0.854,"PCK2, ALDH2, PDHA1, ACACA, HAGH, ACYP1, ALDH9A1, ME1, ALDH3A2, DLAT, ACACB, ALDH7A1, GRHPR",0.441291429466834,0.068542129310995,FALSE
+"H520","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.2637,0.74,0.859,3904,1,"FGF3, FGF19, FGF4, CHRM3, FGF21, FGF20, PAK2, FGF9, APC, PAK1, PIP4K2B, MAP2K1, FGFR1, MYL5, MAP2K2, MYLK2, PIK3CA, PPP1CC, BRAF, RAF1, IQGAP3, SOS1, FGFR3, CYFIP2, GIT1, TIAM1, PIK3CB, PFN2, PIKFYVE, WAS, FGF22, FGF13, ACTN4, NCKAP1, CYFIP1, PPP1CB, SOS2, PIK3R2, DIAPH1",0.0660068361687577,0,FALSE
+"H520","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.47332,1.32,0.109,3806,0.605,"IFNA5, ATG4D, ULK1, GABARAPL2, ATG4B, ULK3, PIK3C3, ATG12, IFNA21",0.962573502059376,0.218244625347531,FALSE
+"H520","Input","KEGG_RENAL_CELL_CARCINOMA",0.36288,1.02,0.417,4593,0.844,"PAK2, PAK1, MAP2K1, MAP2K2, VHL, PIK3CA, PTPN11, TGFB2, BRAF, RAF1, CREBBP, EGLN2, SOS1, EGLN1, PIK3CB, ELOB, FH, VEGFA, SLC2A1, ARNT, ARNT2, SOS2, PIK3R2, AKT2, EPAS1, VEGFD, TGFA, CRKL",0.379863945026242,0.073657553374345,FALSE
+"H520","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.28008,0.777,0.814,4171,1,"THOP1, CMA1, NLN, MME",0.0893755951107988,0,FALSE
+"H520","Input","KEGG_RETINOL_METABOLISM",0.3055,0.853,0.702,4876,1,"UGT2A1, RDH11, CYP1A1, RDH12, ALDH1A1, ADH5, PNPLA4, CYP3A4, DHRS4, DHRS4L2, ALDH1A2, ADH6",0.153662887870195,0,FALSE
+"H520","Input","KEGG_RIBOFLAVIN_METABOLISM",0.50449,1.4,0.0801,2284,0.526,"MTMR2, RFK, ACP1, ACP4",1.09636748391576,0.279014255846261,FALSE
+"H520","Input","KEGG_RIBOSOME",0.18726,0.524,0.988,5341,1,"RPS8, RPS28, RSL24D1, RPL22, RPL35A, MRPL13, RPLP0, RPL23A, RPS15, RPS6, RPL36, RPS2, RPS24, RPL18A, RPL4, RPS15A, RPL17, RPL26L1, FAU, RPLP1",0.00524305541237188,0,FALSE
+"H520","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.20526,-0.743,0.831,17783,0.886,"MAPK11, CXCL8, IL12A, IRF3, TBK1, CASP10, TRADD, TBKBP1, IKBKE",0.080398976215889,0.0525662781129492,FALSE
+"H520","Input","KEGG_RNA_DEGRADATION",0.54896,1.52,0.0344,4748,0.647,"CNOT1, EXOSC6, CNOT8, LSM1, CNOT6, DCP2, HSPA9, PAPOLG, EDC4, CNOT9, LSM7, EXOSC3, DCP1A, PARN, LSM3, EXOSC8, HSPD1, DCPS, DDX6, LSM4, XRN1, TENT4A, EDC3, CNOT7, CNOT6L, TTC37, EXOSC1, ENO3, EXOSC5, ZCCHC7",1.46344155742847,0.1890957193313,FALSE
+"H520","Input","KEGG_RNA_POLYMERASE",0.41161,1.14,0.242,4730,0.788,"POLR2D, POLR3A, POLR2G, POLR2H, POLR2C, POLR2E, POLR1E, POLR3G, POLR2J, POLR1D, POLR2K",0.616184634019569,0.103473782510445,FALSE
+"H520","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.51987,1.46,0.063,2788,0.602,"LCMT1, PAPSS1, CBS, MAT2A, SEPHS2, MAT2B, LCMT2, SEPHS1, SCLY",1.20065945054642,0.220403508742175,FALSE
+"H520","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.28067,-0.985,0.383,15230,0.734,"PIK3R1, LAMC3, TRAF3, ITGA2, NFKBIA, ITGA2B, CCNE1, AKT3, IKBKB, MAX, LAMA1, LAMC2, PTGS2, ITGAV, COL4A2, TRAF5, LAMA4, LAMB2, RXRA, LAMA3, BIRC3, PIAS3, COL4A1, TP53, LAMA5, PIK3CD, ITGB1, LAMB3, ITGA3, LAMB1",0.416801226031377,0.134303940083929,FALSE
+"H520","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.37511,1.05,0.353,3953,0.854,"GOSR1, STX5, SEC22B, USE1, TSNARE1, VAMP1, STX6, SNAP47, VAMP2, STX10, BNIP1, STX17",0.452225294612177,0.068542129310995,FALSE
+"H520","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.3388,-1.21,0.13,17158,0.745,"SPTLC1, SGMS1, PLPP1, SMPD1, GLB1, PLPP3, SGMS2, NEU1, UGCG, SPHK1, SMPD2",0.886056647693163,0.127843727251707,FALSE
+"H520","Input","KEGG_SPLICEOSOME",0.46757,1.3,0.135,5966,0.597,"PPIE, TRA2B, CTNNBL1, RBM17, ISY1, XAB2, PPIH, THOC3, SF3A2, LSM7, NCBP2, SNRPA, DHX8, SRSF5, HNRNPA1L2, LSM3, HNRNPM, SLU7, HNRNPU, HNRNPA1, USP39, RBMX, RBM22, SRSF3, SRSF10, SF3B1, THOC1, ZMAT2, DDX5, LSM4, BUD31, SRSF9, DHX38, TXNL4A, PRPF40A, U2SURP, DDX46, HSPA1L, THOC2, SRSF1, SMNDC1, AQR, CDC40, ALYREF, CHERP, SNRPF, SNRNP200, PRPF40B, HNRNPA3, SRSF8, SNRPG, SRSF2, PRPF3, DHX16, SART1, RBM8A, SNW1, MAGOHB, SRSF7, BCAS2, SF3A1, DDX42, SNRPD1, PLRG1, LSM5, HNRNPK, TCERG1, SNRPA1",0.869666231504994,0.224025668870631,FALSE
+"H520","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.23507,-0.881,0.562,16846,0.797,"UGDH, GYS1, ENPP1, UXS1, AMY2B, PYGB, PGM1",0.250263684430939,0.0985416786038876,FALSE
+"H520","Input","KEGG_STEROID_BIOSYNTHESIS",-0.39516,-1.47,0.0319,16365,0.762,"SQLE, DHCR24, MSMO1, LIPA",1.49620931694282,0.1180450286604,FALSE
+"H520","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.38192,1.07,0.335,4734,0.91,"UGT2A1, AKR1C1, AKR1C2, SRD5A3, AKR1C3, CYP1A1, HSD17B12, CYP3A4, SRD5A1, HSD11B2, AKR1C4, HSD17B8, SULT1E1",0.474955192963155,0.0409586076789064,FALSE
+"H520","Input","KEGG_SULFUR_METABOLISM",0.42826,1.21,0.195,5228,0.679,"PAPSS1, SUOX, SULT1A3, BPNT1, SULT1E1, SULT1A4, SULT1A1",0.709965388637482,0.168130225719498,FALSE
+"H520","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.38175,-1.41,0.143,13039,0.67,"IL10, FCGR2B, FCGR2C, GRIN2A, C1R, C6, C4B, C2, GRIN2B, C7, SNRPB, ACTN1, TNF, ACTN2, C4A, FCGR1A, ELANE, C1S, TRIM21, FCGR2A, CD40, C3",0.844663962534938,0.173925197299174,FALSE
+"H520","Input","KEGG_TASTE_TRANSDUCTION",0.20059,0.564,0.983,5077,1,"GNB1, SCNN1A, PRKX, CACNA1B, PRKACB, TAS1R3, GNB3, GNG3, PRKACA, TAS2R46, TAS2R14",0.00744648216786438,0,FALSE
+"H520","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.53476,1.48,0.0465,2943,0.585,"ADO, CSAD, GAD1",1.33254704711005,0.23284413391782,FALSE
+"H520","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.25099,-0.93,0.533,4793,0.748,"GGPS1, ACAT1, ACAT2, PDSS1, MVD, IDI2, FDPS, PMVK, DHDDS, HMGCS1, MVK, HMGCR, HMGCS2, IDI1, PDSS2",0.273272790973428,0.126098402135539,FALSE
+"H520","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.3788,1.06,0.356,6086,0.88,"BMP8A, NODAL, INHBE, INHBC, PPP2CA, AMH, BMP8B, ID4, SP1, TGFB2, THBS4, SMAD9, SMAD5, CREBBP, BMP7, SMAD4, PPP2R1B, SMAD1, INHBB, RBL1, ID3, RPS6KB2, E2F4, RBL2, BMP4, TGFBR1, SKP1, SMAD2, SMAD6, EP300, BMPR1A, MAPK1, SMAD7, MYC, BMPR2, ROCK2, CDKN2B, ACVR2B, RPS6KB1",0.448550002027125,0.0555173278498314,FALSE
+"H520","Input","KEGG_THYROID_CANCER",0.43985,1.22,0.194,1729,0.666,"TCF7, MAP2K1, MAP2K2, LEF1, TCF7L2, BRAF",0.712198270069774,0.176525770829699,FALSE
+"H520","Input","KEGG_TIGHT_JUNCTION",0.23182,0.645,0.935,4500,1,"MYH7B, CTNNA2, PRKCQ, PPP2CA, CSNK2A2, MYL5, RAB3B, MYH11, PPP2R2C, EPB41L3, PATJ, CTNNA1, PPP2R1B, CTNNB1, CRB3, ACTN4, PARD6A, MAGI1, LLGL2, F11R, AKT2, CLDN7, AFDN, PRKCZ, GNAI1, TJAP1, MYH3",0.0291883891274822,0,FALSE
+"H520","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.18983,0.539,0.992,4567,1,"IFNA5, MAP2K1, MAP2K7, MAP2K2, PIK3CA, MAP2K6, IFNAR1, MAPK9, MAP3K7, PIK3CB, SPP1, TIRAP, IFNA21, PIK3R2, AKT2, TAB1, MAP2K4, IRAK1",0.00348832784582135,0,FALSE
+"H520","Input","KEGG_TRYPTOPHAN_METABOLISM",0.35087,0.982,0.463,2805,0.909,"MAOB, WARS2, ALDH2, ALDH9A1, CYP1A1, HADH, HADHA, AFMID",0.334419008982047,0.0414361167780325,FALSE
+"H520","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.43421,1.23,0.174,3844,0.735,"CACNA1E, ADIPOQ, SOCS4, PIK3CA, MAPK9, MTOR, PIK3CB, KCNJ11, CACNA1B, HK2, ABCC8, SOCS1, PIK3R2",0.7594507517174,0.133712660915805,FALSE
+"H520","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.30032,0.84,0.737,4971,1,"PRF1, ICA1, HSPD1, GAD1, LTA, CPE, FASLG",0.132532512140949,0,FALSE
+"H520","Input","KEGG_TYROSINE_METABOLISM",0.33098,0.929,0.584,3224,0.946,"LCMT1, GOT2, MAOB, DBH, ALDH3A1, LCMT2, DCT, ADH5",0.233587152887601,0.0241088635982073,FALSE
+"H520","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.34281,0.959,0.53,4425,0.894,"CTLA4, MALT1, PAK2, PAK1, PRKCQ, NFATC3, MAP2K1, MAP2K7, MAP2K2, PIK3CA, PDPK1, RAF1, MAPK9, FYN, CBL, SOS1, MAP3K7, PPP3R1, PIK3CB, NFKBIB, NCK1, GSK3B, SOS2, PIK3R2, AKT2, PTPN6, CD8A, DLG1",0.275724130399211,0.0486624812040823,FALSE
+"H520","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.43433,1.22,0.182,5850,0.666,"UBE2NL, UBE2D2, UBE2QL1, CDC34, KEAP1, UBE2R2, UBE2I, UBE2B, SIAH1, CDC23, FZR1, WWP1, VHL, COP1, CDC20, MGRN1, CUL5, PIAS4, CBL, UBE3A, XIAP, UBE2N, WWP2, CUL3, UBA2, CUL4B, ELOB, ANAPC7, SYVN1, HERC2, HERC1, KLHL9, SKP2, ANAPC1, UBE2Q1, SOCS1, UBE2J2, UBE2A, CDC27, STUB1, FANCL, UBE4B, FBXW11, RNF7, PIAS2, UBE2D3, SKP1, UBE2W, TRIM37, UBE2K, FBXW7, UBR5, ANAPC11, UBE2S, UBE4A, UBE2O, DDB2, PIAS1, BIRC6, MID1, TRIP12, BRCA1, UBE2J1, DDB1, UBE2M, FBXW8",0.739928612014925,0.176525770829699,FALSE
+"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.47841,1.33,0.114,7811,0.6,"PDHA1, LARS2, IARS2, BCAT2, BCAT1, VARS2",0.943095148663527,0.221848749616356,FALSE
+"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37206,1.03,0.396,6698,0.85,"OXCT2, ACAA2, ALDH2, ALDH9A1, HADH, HADHA, HIBCH, BCKDHA, ALDH3A2, IVD, ACAD8, ALDH6A1, DBT, MCCC2, MCCC1, ALDH7A1, ACADSB, PCCB, EHHADH, MCEE, ACAT1, BCKDHB, HSD17B10, OXCT1, ECHS1",0.402304814074488,0.0705810742857073,FALSE
+"H520","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.24862,0.696,0.9,3711,1,"ADCY7, ITPR1, PRKCQ, MAP2K1, MAP2K2, MYLK2, MYH11, PPP1CC, BRAF, GNA11, RAF1, KCNMA1, PLA2G12A, PRKX, ARHGEF11, KCNMB3, ADCY1, NPR2, PRKACB, CALML5, PLA2G3, PPP1CB",0.0457574905606751,0,FALSE
+"H520","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.34212,0.962,0.518,5771,0.897,"DYNC1I1, DYNC1LI2, RAB11B, DCTN5, CREB1, DCTN4, PRKX, VAMP2, PRKACB, RAB11A, CREB3L4, DYNLL2, PRKACA, DYNC1H1, RAB5A, CREB3, DCTN1",0.285670240254767,0.0472075569559079,FALSE
+"H520","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.21206,-0.753,0.856,16861,0.889,"SH2D2A, PTGS2, NOS3, NFATC2, PLCG2, PRKCA, MAPK11, NFATC1, RAC2, PIK3CD, CDC42, HSPB1, SPHK1, PXN",0.0675262353228468,0.0510982390297863,FALSE
+"H520","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25291,-0.895,0.566,17236,0.786,"ATP6V1E1, PDIA4, PLCG2, ERO1A, GNAS, ATP6V1B1, PRKCA, ATP6V1G1, ADCY9, ATP6V1F, ACTB, KDELR3, TCIRG1",0.247183568811729,0.104577453960592,FALSE
+"H520","Input","KEGG_VIRAL_MYOCARDITIS",0.24931,0.695,0.901,2208,1,"MYH7B, PRF1, MYH11, SGCG, FYN",0.045275209020937,0,FALSE
+"H520","Input","KEGG_WNT_SIGNALING_PATHWAY",0.37476,1.04,0.37,6720,0.831,"NKD1, WIF1, DKK2, DVL3, TBL1XR1, AXIN2, TCF7, SENP2, APC, PPP2CA, CSNK2A2, SIAH1, NFATC3, FZD1, NLK, TBL1X, LEF1, WNT11, CTBP1, TCF7L2, FZD3, MAPK9, CREBBP, SMAD4, MAP3K7, LRP6, PPP2R1B, NKD2, PPP3R1, AXIN1, CACYBP, CTNNB1, PRKX, RUVBL1, PRKACB, PPP2R5E, FZD10, GSK3B, WNT8B, RAC3, PLCB1, CAMK2G, FBXW11, PPP2R5D, SKP1, FRAT2, LRP5, SMAD2, CSNK2A1, PRKACA, WNT5A, PPARD, EP300, FRAT1, PSEN1, SFRP5, CTBP2, MYC, CSNK1E, ROCK2, CAMK2A, VANGL1, PPP2R5C, FZD8, FZD6, PPP2R5A, WNT16, WNT2B, DVL1, JUN, NFATC4, DVL2, NFAT5, CHD8, MAPK8, WNT6",0.431798275933005,0.080398976215889,FALSE
+"H460","Input","KEGG_ABC_TRANSPORTERS",0.42084,1.57,0.0356,3238,0.189,"ABCC9, ABCB10, ABCC2, ABCA8, ABCG2, ABCB6, ABCB7, TAP2, ABCB1, ABCC3, ABCB8, ABCA2, ABCC1",1.44855000202712,0.723538195826756,TRUE
+"H460","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.49963,-1.73,0.0217,16075,0.345,"LEF1, TCF7, SOS1, RARA, RUNX1, RAF1, STAT5A, PIM1, KRAS, PIK3CD, RPS6KB2, PIK3R3, AKT2, NRAS, RELA, BRAF, MAPK3, MAPK1, TCF7L1, SOS2, PPARD, STAT3, PIK3CA",1.66354026615147,0.462180904926726,FALSE
+"H460","Input","KEGG_ADHERENS_JUNCTION",-0.51863,-1.79,0.0165,16075,0.512,"LEF1, PTPRF, TCF7, PTPRB, AFDN, CDH1, BAIAP2, RAC1, SORBS1, EP300, MAP3K7, RAC2, MAPK3, INSR, CTNND1, MAPK1, PTPN1, CDC42, NECTIN2, TCF7L1, CREBBP, NLK, SMAD3, WASF2, NECTIN3, TGFBR2, LMO7, CSNK2B, FYN, CSNK2A1",1.78251605578609,0.290730039024169,FALSE
+"H460","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.24182,-0.841,0.691,16420,0.832,"MAPK10, PRKAB1, ACSL5, AKT2, RELA, ADIPOR2, NFKBIE, PPARA, CPT1B, MAPK8, STAT3, RXRB",0.160521952625802,0.0798766737092761,FALSE
+"H460","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.31223,1.09,0.292,2951,0.433,"CPS1, GOT2, CAD, ADSL, ASS1, PPAT, GOT1",0.534617148551582,0.363512103646635,FALSE
+"H460","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.3695,-1.32,0.132,11790,0.374,"FXYD2, SCNN1G, KCNJ1, ATP1B2, PIK3R2, HSD11B1, SCNN1B, PDPK1, PIK3CB, PRKCG, PIK3R1, ATP1A1, NR3C2, NEDD4L, SCNN1A, KRAS, PIK3CD, PIK3R3, MAPK3, INSR, MAPK1, PIK3CA",0.87942606879415,0.42712839779952,FALSE
+"H460","Input","KEGG_ALLOGRAFT_REJECTION",0.34225,1.23,0.167,12576,0.33,"CD40, FAS, IL12A, CD86, CD80, PRF1, IFNG, CD40LG, IL2, CD28, GZMB, FASLG, IL5, IL4, IL10, IL12B, TNF",0.777283528852417,0.481486060122112,FALSE
+"H460","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.24553,-0.847,0.672,18188,0.83,"PLA2G6, ACOX3",0.172630726946175,0.0809219076239261,FALSE
+"H460","Input","KEGG_ALZHEIMERS_DISEASE",0.39065,1.38,0.114,3200,0.265,"CASP7, ATP5F1B, NDUFB10, SNCA, CASP9, NAE1, NDUFS2, ATP5MC1, HSD17B10, UQCRC2, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, NDUFB8, COX7C, CALM1, NDUFA5, NDUFA1, PLCB1, COX5A, COX7B, ITPR1, MAPT, IDE, GAPDH, NDUFB3, UQCRQ, NDUFB1, COX5B, CASP8, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, TNFRSF1A, NDUFS7, ATF6, NDUFV3, ATP5MC2, ATP5F1D, NDUFS4, NDUFA7, NDUFC1, COX6A1, COX6B1, UQCRH, PSEN2, CYCS, BACE2, SDHD, NDUFS5",0.943095148663527,0.576754126063192,FALSE
+"H460","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.6345,2.33,0.00284,1069,0.0574,"IARS2, MARS2, FARSB, EARS2, DARS2, MTFMT, HARS2, LARS2, TARS2",2.54668165995296,1.24108810760203,TRUE
+"H460","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.23375,0.849,0.634,4169,0.728,"UGDH, GPI, GALK2, PMM2, GNPDA1, GNPDA2, GNPNAT1, NANS, PGM2, HK1, HK2, NPL, NANP, GALE",0.197910742118267,0.137868620686963,FALSE
+"H460","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.28873,-1.01,0.411,16132,0.62,"DERL1, CCS, PPP3CB, APAF1, MAPK13, CASP1, PPP3CA, RAC1, MAPK14, BCL2L1, RAB5A, CAT",0.386158178123931,0.207608310501746,FALSE
+"H460","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.35367,1.26,0.174,1789,0.343,"HSP90AA1, CTSL, CANX, IFNA21, HSP90AB1, HSPA5, PSME3, HSPA1A, HSPA8, HSPA1B, TAP2, HSPA4",0.7594507517174,0.464705879957229,FALSE
+"H460","Input","KEGG_APOPTOSIS",0.22691,0.806,0.705,1947,0.783,"CASP7, CASP9, AIFM1, NTRK1, IKBKG, ENDOG, TNFRSF10A, IRAK1, TRADD, BCL2, AKT1, PRKX, PRKAR1A, CHUK, CASP8",0.151810883008601,0.106238237942057,FALSE
+"H460","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.46452,1.66,0.0483,656,0.173,"HPGDS, PLA2G4A, AKR1C3, GGT1, PTGES2, GPX3",1.31605286924849,0.761953896871205,TRUE
+"H460","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.42754,1.53,0.0612,1837,0.201,"CPS1, GOT2, ALDH9A1, ODC1, ALDH18A1, CKB, SRM, LAP3, PYCR2, ALDH3A2, P4HA3, AGMAT, ALDH1B1, PYCR1",1.21324857785444,0.696803942579511,FALSE
+"H460","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.26891,-0.941,0.5,11469,0.716,"SGCG, CACNG6, SGCA, CTNNA2, DAG1, SGCD, ITGB8, CACNG7, ITGA11, LAMA2, ITGA9, ACTN4, ITGB7, CACNA2D4, PKP2, CTNNB1, ITGA10, ITGA1, CACNA1D, CACNB4, ITGA4, ITGB1, CACNB3, LEF1, TCF7, ITGB6, ITGB3, ITGB4, ITGAV, ITGA7, ITGA2, CDH2, TCF7L1, DSP, ITGA3",0.301029995663981,0.145086977692144,FALSE
+"H460","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56121,1.97,0.0118,1779,0.102,"UGDH, ALDH9A1, ALDH3A2, ALDH1B1",1.92811799269387,0.991399828238082,TRUE
+"H460","Input","KEGG_ASTHMA",-0.30735,-1.06,0.34,7286,0.627,"CD40LG, IL3, CCL11, IL5, IL4, IL10, PRG2, EPX, FCER1G, RNASE3, TNF, IL13",0.468521082957745,0.202732459169284,FALSE
+"H460","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.33144,1.2,0.187,11222,0.328,"IFNA21, TPO, CD40, FAS, CD86, CD80, IFNA4, PRF1, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, IL2, CD28, GZMB, TSHR, FASLG, IL5, TSHB, IFNA13, IL4, CTLA4, IL10, CGA, IFNA8, IFNA1, IFNA5",0.728158393463501,0.484126156288321,FALSE
+"H460","Input","KEGG_AXON_GUIDANCE",-0.37738,-1.33,0.119,15092,0.384,"PAK4, SEMA6A, SLIT3, SEMA4D, RASA1, EPHB6, PLXNB2, PLXNC1, PLXNA3, CXCR4, ITGB1, CDK5, PLXNA1, SRGAP1, NCK2, SEMA3F, PTK2, SLIT2, EFNB3, RND1, GNAI3, PPP3CB, GSK3B, SEMA4A, KRAS, SEMA3B, PAK6, ABLIM3, PAK2, CFL1, SEMA4B, PPP3CA, RAC1, NRAS, ROCK1, RAC2, EPHA1, MAPK3, SEMA4C, MAPK1, EFNB2, EPHB3, NRP1, CDC42, SRGAP3, SEMA7A, ARHGEF12, SEMA3C, NFAT5, PLXNB1, EPHB2, FYN",0.924453038607469,0.415668775632469,FALSE
+"H460","Input","KEGG_BASAL_CELL_CARCINOMA",-0.33368,-1.16,0.235,12943,0.535,"WNT8B, WNT6, WNT16, PTCH1, PTCH2, HHIP, FZD1, WNT7A, WNT5B, CTNNB1, WNT4, AXIN2, APC2, STK36, WNT2B, WNT10A, LEF1, TCF7, FZD2, SUFU, APC, FZD6, GSK3B, WNT9A, BMP4, WNT7B, TCF7L1, DVL3",0.628932137728264,0.271646217978772,FALSE
+"H460","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.21663,0.778,0.748,1987,0.82,"GTF2H2, GTF2E2, GTF2A2, TAF9, TAF9B, TAF5",0.126098402135539,0.0861861476162833,FALSE
+"H460","Input","KEGG_BASE_EXCISION_REPAIR",0.56649,2.03,0.00612,2985,0.104,"NEIL3, APEX1, POLE3, PARP1, MPG, POLD2, NTHL1, POLE2, PARP2, LIG3, HMGB1, NEIL2, APEX2, LIG1, TDG, PCNA, SMUG1, UNG, POLE, POLD1",2.21324857785444,0.98296666070122,TRUE
+"H460","Input","KEGG_BETA_ALANINE_METABOLISM",0.36169,1.32,0.118,1898,0.301,"ALDH9A1, SRM, ECHS1, ALDH3A2, AOC3, ALDH1B1, HADHA",0.928117992693875,0.521433504406157,FALSE
+"H460","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29982,1.07,0.308,3570,0.449,"ELOVL6, HADHA, FADS1, ACOT2, SCD, HSD17B12, ACOT1, ACOT4, FADS2, HACD1",0.511449283499556,0.347753658996677,FALSE
+"H460","Input","KEGG_BLADDER_CANCER",-0.42156,-1.47,0.0764,16325,0.439,"DAPK2, DAPK3, RAF1, KRAS, CDH1, MMP2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, DAPK1, VEGFA, VEGFB, THBS1",1.11690664142431,0.357535479757879,FALSE
+"H460","Input","KEGG_BUTANOATE_METABOLISM",0.40645,1.44,0.106,2010,0.224,"AKR1B10, PDHA1, ALDH9A1, L2HGDH, HADH, ECHS1, ALDH3A2, ALDH1B1, HADHA, ACAT1",0.97469413473523,0.649751981665837,FALSE
+"H460","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.4405,-1.53,0.0636,15329,0.396,"DAPP1, RASGRP3, SYK, CD22, SOS1, LILRB3, RAF1, PPP3CB, GSK3B, KRAS, PIK3CD, JUN, PIK3R3, PPP3CA, RAC1, AKT2, NRAS, RELA, CD72, NFKBIE, RAC2, MAPK3, IFITM1, MAPK1, SOS2, NFAT5, BCL10, PIK3CA",1.19654288435159,0.402304814074488,FALSE
+"H460","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.20838,0.721,0.842,1786,0.893,"PDE1A, P2RX5, SLC25A6, VDAC1, SLC25A5, ADCY7, PHKA1, VDAC2, TBXA2R, PDE1C, NTSR1, CALM1, PTK2B, PLCB1, P2RX6, PPID, ITPR1, ADCY3, PRKX, PHKB, ATP2B1, BST1",0.0746879085003505,0.0491485411114536,FALSE
+"H460","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.25388,0.936,0.495,3067,0.615,"CACNA2D3, UQCRC2, TPM3, COX7C, COX5A, COX7B, UQCRQ, COX5B, CACNB2, UQCRHL, ATP1B3, COX6A1, COX6B1, RYR2, UQCRH",0.305394801066431,0.211124884224583,FALSE
+"H460","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.19249,0.697,0.871,734,0.921,"CD226, MPZ, NRCAM, CNTN1",0.0599818449923368,0.0357403698031511,FALSE
+"H460","Input","KEGG_CELL_CYCLE",0.26094,0.952,0.448,3732,0.593,"YWHAE, GADD45G, ANAPC1, SMAD2, ANAPC5, MCM6, ANAPC7, E2F4, BUB3, CDC25A, SMC1A, YWHAG, PTTG1, PLK1, ORC1, CDC26, MCM7, CCNB1, MCM4, CCNH, BUB1, PKMYT1, SKP2, BUB1B, CUL1, ORC2, STAG2, CDK1, PCNA, SFN, ORC6, CDK7, E2F2, MYC, CDC45, CDC6, SMC3, ORC5, CDC25B, MAD2L1, CHEK2, CCND3, ESPL1, CDC23, ANAPC2, CCNA2, ORC4, CDC7, ANAPC11, CCNB2",0.348721986001856,0.226945306635737,FALSE
+"H460","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.26526,-0.928,0.499,13226,0.733,"ADCY4, WASL, GNG3, VAV3, ROCK2, DOCK2, CXCL12, GRK4, PIK3CB, VAV1, XCL1, PRKCD, PRKCZ, NFKBIA, PIK3R1, CXCR6, ARRB1, GRK3, ADCY5, CCL26, JAK2, PXN, RASGRP2, CCL5, GNB1, GNG7, CX3CL1, CXCR4, CCL2, GNG2, GSK3A, SOS1, GNG4, SHC2, PTK2, TIAM1, RAF1, GNAI3, GNG5, GSK3B, CRKL, KRAS, PIK3CD, CCL28, PIK3R3, GRK5, RAC1, PRKACA, PREX1, AKT2, NRAS, RELA, BRAF, ROCK1, RAC2, MAPK3, MAPK1, CDC42, RAP1A, ADCY6, SOS2, BCAR1, TIAM2, STAT3, STAT2, PIK3CA, FOXO3",0.30189945437661,0.134896025358872,FALSE
+"H460","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.50074,-1.74,0.0257,16534,0.396,"SHC2, RUNX1, RAF1, STAT5A, CRKL, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, RELA, BRAF, MAPK3, CBLB, MAPK1, CDKN2A, SMAD3, CBL, MECOM, BCL2L1, GAB2, TGFBR2, SOS2, HDAC1, PIK3CA, CDKN1B",1.59006687666871,0.402304814074488,FALSE
+"H460","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.55384,-1.91,0.0166,17307,0.404,"NR1D1, CSNK1E, ARNTL, PER3, CRY2",1.77989191195995,0.393618634889395,FALSE
+"H460","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.64971,2.39,0,3190,0.0778,"FH, PDHA1, IDH3A, CS, SUCLG1, DLD, DLAT, MDH2, DLST, IDH1, IDH3B, IDH3G, ACLY, SDHC, SDHB, OGDH, ACO2, PDHB, SDHD",Inf,1.10902040301031,TRUE
+"H460","Input","KEGG_COLORECTAL_CANCER",-0.40113,-1.38,0.105,16075,0.414,"LEF1, TCF7, MAPK10, APC, RAF1, GSK3B, KRAS, PIK3CD, JUN, PIK3R3, RAC1, AKT2, BRAF, RAC2, MAPK3, MAPK1, TCF7L1, SMAD3, MAPK8, TGFBR2, PIK3CA",0.978810700930062,0.382999658879101,FALSE
+"H460","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.23859,-0.826,0.709,13582,0.842,"SERPINA5, VWF, C3, C3AR1, MASP2, C4BPB, F8, SERPINF2, C2, BDKRB1, C1R, CFI, SERPING1, SERPINE1, C4B, SERPINA1, F2R, BDKRB2, C4A, F3, C5, CFB, CD59",0.149353764816933,0.0746879085003505,FALSE
+"H460","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.43015,1.54,0.0862,3562,0.201,"GOT2, AHCY, SRM, AHCYL2, MAT2A, LDHA, ENOPH1, LDHB, DNMT1, GOT1, MTAP, CTH, MTR, SMS, AHCYL1",1.06449273417529,0.696803942579511,FALSE
+"H460","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.1737,0.6,0.977,1310,0.997,"TNFRSF8, IL18RAP, CXCL5, OSM, FLT4, IL18R1, CD70, CXCL1, IFNA21, EGF, CSF2RA, PF4V1, TNFSF9, IL22RA1, EDA2R, TNFRSF10A, CXCL8, IL6, CXCL2",0.0101054362812269,0.00130484168834428,FALSE
+"H460","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.28,0.978,0.43,3016,0.562,"POLR3K, POLR3G, IFNA21, IKBKG, TREX1, IL6, POLR3B, CHUK, POLR3D, POLR3GL, POLR3A, TBK1, ADAR",0.366531544420413,0.250263684430939,FALSE
+"H460","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.19571,-0.68,0.902,10525,0.979,"CACNB1, CACNG8, MYL3, CACNG1, ACTC1, CACNA2D2, ADCY2, TNNI3, IGF1, MYL2, SGCG, CACNG6, SGCA, DAG1, SGCD, ITGB8, CACNG7, ITGA11, TNF, LAMA2, ITGA9, ADCY4, ITGB7, CACNA2D4, ADCY5, TNNT2, ITGA10, ITGA1, TPM4, CACNA1D, CACNB4, ITGA4, ITGB1, CACNB3, TNNC1, ITGB6, ITGB3, ITGB4, ITGAV, ITGA7, PRKACA, ITGA2, TPM1, ITGA3, ADCY6",0.0447934624580583,0.00921730819686218,FALSE
+"H460","Input","KEGG_DNA_REPLICATION",0.66538,2.34,0.0115,3867,0.077,"RNASEH1, POLE3, PRIM1, MCM6, RFC2, POLA1, POLD2, RFC5, RPA4, POLE2, SSBP1, MCM7, MCM4, LIG1, PCNA, DNA2, RFC3, RPA2, POLE, POLD1, FEN1, RNASEH2A, RPA1, MCM5",1.93930215964639,1.11350927482752,TRUE
+"H460","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.44443,-1.54,0.0586,12777,0.449,"PIWIL2, NOTCH4, ETV7, ETS1, EGFR, SPIRE1, NOTCH2, SOS1, PIWIL4, KRAS, ETS2, MAPK3, MAPK1, SOS2, ETV6",1.23210238398191,0.347753658996677,FALSE
+"H460","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.25493,0.902,0.5,2218,0.638,"ALDH3A1, GSTM1, GSTM3, GSTO2, MGST1, ALDH3B1, GSTM4, GSTO1, MGST2",0.301029995663981,0.195179321278838,FALSE
+"H460","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.24597,0.903,0.546,2401,0.644,"UCK2, IMPDH1, CES2, HPRT1, IMPDH2, CES1, ITPA",0.262807357295263,0.191114132640188,FALSE
+"H460","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.2311,0.831,0.616,255,0.754,"COL4A6, TNXB, LAMC3, LAMA1, SPP1, COL5A2",0.210419287835575,0.122628654130226,FALSE
+"H460","Input","KEGG_ENDOCYTOSIS",-0.39122,-1.34,0.12,13552,0.383,"GRK4, MDM2, AP2A1, SMAP2, VPS37C, PLD2, KIT, IL2RG, PDGFRA, USP8, SH3GL3, CSF1R, EGFR, PRKCZ, ARRB1, GRK3, DNM3, ACAP1, STAM, SH3GL1, DNM1, STAM2, ARAP2, CHMP2A, EPN3, AGAP2, VPS36, CHMP3, CBLC, CXCR4, RAB11B, VTA1, CLTCL1, SH3GLB2, VPS4B, AP2A2, SMURF1, RAB11FIP1, RAB11FIP4, PIP5K1C, FGFR2, F2R, NEDD4L, SMAP1, ASAP1, PDCD6IP, RAB11A, DNM1L, ADRB2, PARD6A, AP2M1, CHMP5, TSG101, ARF6, GRK5, CBLB, CDC42, CHMP2B, ARFGAP3, ERBB3, ACAP2, PSD4, CBL, DAB2, PARD6B, CHMP4B, DNM2, ARAP1, ITCH, VPS37B, EHD2, TRAF6, RAB22A, ARFGAP2, RAB5A, PRKCI, SH3GLB1, SMURF2, VPS28, EPS15, RAB5B",0.920818753952375,0.416801226031377,FALSE
+"H460","Input","KEGG_ENDOMETRIAL_CANCER",-0.44705,-1.56,0.05,14135,0.452,"EGFR, PIK3R1, CTNNB1, ERBB2, CCND1, AXIN2, APC2, LEF1, TCF7, SOS1, APC, RAF1, GSK3B, KRAS, PIK3CD, CDH1, PIK3R3, AKT2, NRAS, BRAF, MAPK3, MAPK1, TCF7L1, ILK, SOS2, PIK3CA, FOXO3",1.30102999566398,0.344861565188618,FALSE
+"H460","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.26959,-0.92,0.513,13744,0.74,"PTPRZ1, IGSF5, EGFR, JAM2, NFKBIA, ATP6V1G2, ADAM10, CCL5, ATP6V1B2, MAPK11, F11R, PLCG1, MAPK10, ATP6V1A, HBEGF, MAPK13, ATP6V1E1, JUN, RAC1, ATP6V1C1, RELA, CDC42, MAPK14, MAPK8, ATP6V1H",0.289882634888184,0.130768280269024,FALSE
+"H460","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.39252,-1.36,0.114,16073,0.395,"PLCG1, SOS1, MAPK10, NCK2, SHC2, PTK2, RAF1, BTC, STAT5A, GSK3B, CRKL, KRAS, PIK3CD, PAK6, HBEGF, PAK2, JUN, RPS6KB2, PIK3R3, AKT2, NRAS, BRAF, MAPK3, CBLB, MAPK1, ERBB3, TGFA, CBL, GAB1, MAPK8, SOS2, PIK3CA, CDKN1B",0.943095148663527,0.40340290437354,FALSE
+"H460","Input","KEGG_ETHER_LIPID_METABOLISM",0.23702,0.862,0.587,1308,0.71,"PLA2G7, PLA2G4A, CHPT1",0.231361898752386,0.148741651280925,FALSE
+"H460","Input","KEGG_FATTY_ACID_METABOLISM",0.30319,1.07,0.301,2664,0.449,"ALDH9A1, HADH, ECHS1, ALDH3A2, ACADSB, ALDH1B1, HADHA, ACAT1, ACAA2, ECI2, ACADS",0.521433504406157,0.347753658996677,FALSE
+"H460","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.39513,-1.38,0.104,15701,0.414,"SYK, MAPK11, PLCG1, SOS1, MAPK10, PRKCE, RAF1, KRAS, PIK3CD, MAPK13, PIK3R3, RAC1, AKT2, NRAS, RAC2, MAPK3, MAPK1, MAPK14, PLA2G6, GAB2, MAPK8, SOS2, FYN, PIK3CA",0.98296666070122,0.382999658879101,FALSE
+"H460","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.41854,-1.45,0.0894,13117,0.397,"LIMK2, PLA2G4F, WASL, AMPH, FCGR1A, VAV3, DOCK2, ARPC3, LAT, PIK3CB, VAV1, PLD2, SPHK1, PRKCD, PRKCG, PIK3R1, DNM3, SPHK2, DNM1, SYK, VASP, PLCG1, PLPP3, PIP5K1C, PRKCE, RAF1, ASAP1, DNM1L, CRKL, PIK3CD, CFL1, ARF6, RPS6KB2, PIK3R3, RAC1, AKT2, RAC2, MAPK3, MARCKSL1, MAPK1, CDC42, WASF2, PLA2G6, DNM2, GAB2, GSN, MARCKS, PIK3CA",1.04866248120408,0.401209493236885,FALSE
+"H460","Input","KEGG_FOCAL_ADHESION",-0.30502,-1.06,0.349,13444,0.627,"VAV3, XIAP, ROCK2, THBS4, PGF, VWF, ACTN4, PIK3CB, VAV1, ITGB7, PDGFRA, PRKCG, COL5A1, LAMB3, THBS2, EGFR, PDGFA, PIK3R1, CTNNB1, ERBB2, CCND2, CCND1, ITGA10, ITGA1, PXN, LAMA3, MYLPF, CHAD, MYLK2, COL1A2, PAK4, PDGFC, ITGA4, RASGRF1, PPP1CA, PDGFD, ITGB1, VASP, COL11A2, SOS1, MYL9, ITGB6, ITGB3, LAMC2, PIP5K1C, MAPK10, COL6A2, SHC2, ITGB4, PTK2, FLNC, RAF1, ITGAV, ITGA7, LAMA4, MYL12A, GSK3B, CRKL, MYL12B, PIK3CD, BIRC3, PAK6, PARVA, PAK2, JUN, PIK3R3, RAC1, PPP1CB, ITGA2, AKT2, BRAF, ROCK1, RAC2, ARHGAP35, MAPK3, BIRC2, MAPK1, CDC42, VEGFA, TNC, PDGFB, ILK, ARHGAP5, MYLK, RAP1A, ITGA3, VEGFB, MAPK8, THBS1, TLN2, SOS2, BCAR1, FYN, PIK3CA",0.45717457304082,0.202732459169284,FALSE
+"H460","Input","KEGG_FOLATE_BIOSYNTHESIS",0.39893,1.44,0.081,3512,0.224,"SPR, QDPR, PTS, DHFR",1.09151498112135,0.649751981665837,FALSE
+"H460","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.40984,1.47,0.0667,4560,0.233,"AKR1B10, SORD, ALDOA, PFKM, PMM2, PFKP, PHPT1, KHK, AKR1B1, PFKL, ALDOC, HK1, HK2, MTMR2, TPI1, GMPPB, GMDS",1.17587416608345,0.632644078973981,FALSE
+"H460","Input","KEGG_GALACTOSE_METABOLISM",0.3813,1.37,0.126,3880,0.267,"GLA, PFKM, GALK2, PFKP, G6PC2, AKR1B1, PFKL, PGM2, HK1, B4GALT2, HK2",0.899629454882437,0.573488738635425,FALSE
+"H460","Input","KEGG_GAP_JUNCTION",0.18685,0.666,0.892,2889,0.952,"TUBB4A, EGF, ADCY7, SRC, TUBA1B, PLCB1, TUBB3, ITPR1, TUBA1A, ADCY3, PRKX, TUBA4A, CDK1, TUBAL3, GJA1, PRKCB, TUBB4B, TUBA1C",0.0496351456238769,0.0213630516155257,FALSE
+"H460","Input","KEGG_GLIOMA",-0.33716,-1.16,0.228,13607,0.535,"MDM2, PIK3CB, E2F3, PDGFRA, PRKCG, EGFR, PDGFA, PIK3R1, CCND1, CALML6, PLCG1, SOS1, CALM3, SHC2, RAF1, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, PDGFB, TGFA, SOS2, PIK3CA",0.642065152999546,0.271646217978772,FALSE
+"H460","Input","KEGG_GLUTATHIONE_METABOLISM",0.53525,1.97,0.0151,2592,0.102,"G6PD, GSTM1, PGD, GSR, ODC1, GGT1, GPX3, GCLM, GCLC, GSTM3, GSTO2, RRM2, SRM, LAP3, IDH1, MGST1, GSTM4, GSTO1, MGST2, GGCT, GSTM2",1.82102305270683,0.991399828238082,TRUE
+"H460","Input","KEGG_GLYCEROLIPID_METABOLISM",0.27647,0.991,0.401,1938,0.548,"GLA, DGKD, DGKG, ALDH9A1, GPAT3, ALDH3A2, ALDH1B1, AGK",0.396855627379818,0.261219441515631,FALSE
+"H460","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.237,-0.828,0.693,17294,0.849,"DGKA, CDS1, ETNK1, LPCAT2, MBOAT2, CDS2, DGKH, PLA2G6, CHKA, ETNK2, CHKB",0.159266765388193,0.0710923097560473,FALSE
+"H460","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.22591,-0.785,0.763,13271,0.868,"GCAT, MAOB, PIPOX, DMGDH, SRR, SARDH, GNMT, AMT, GATM, PSPH",0.11747546204512,0.0614802748235081,FALSE
+"H460","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.44645,1.62,0.0562,3658,0.184,"ALDH3A1, PDHA1, ALDH9A1, ALDOA, PFKM, PGAM1, DLD, GPI, ENO1, DLAT, ALDH3A2, PGK1, GAPDH, ALDH3B1, ALDH1B1, LDHA, PFKP, G6PC2, PGAM4, LDHB, PDHB, PKM, PFKL, ALDOC, PGM2, HK1",1.25026368443094,0.735182176990464,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.34649,1.21,0.195,1325,0.334,"CHSY3, CSGALNACT1, XYLT1, CHST15",0.709965388637482,0.476253533188435,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.34926,1.21,0.209,1267,0.334,"GLCE, HS6ST2, XYLT1, HS3ST3B1, HS3ST3A1",0.679853713888946,0.476253533188435,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.40258,-1.4,0.0916,15626,0.417,"B3GNT7, CHST2, FUT8, ST3GAL3, B4GALT4, B3GNT2",1.03810452633215,0.379863945026242,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.26732,0.962,0.462,1267,0.583,"HYAL1, HS3ST3B1, HS3ST3A1",0.335358024443874,0.234331445240986,FALSE
+"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.30879,1.12,0.253,965,0.404,"ST6GALNAC4, B4GALNT1, ST3GAL1",0.596879478824182,0.393618634889395,FALSE
+"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.33252,1.2,0.196,965,0.328,"GLA, ST3GAL1",0.707743928643524,0.484126156288321,FALSE
+"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.41974,-1.45,0.0711,10585,0.397,"FUT5, FUT9, B4GAT1, FUT6, B3GALT2, B4GALT1, FUT4, B3GALT1, B3GNT4, ABO, FUT2, B3GNT5, FUT3, B3GALT5, ST8SIA1, B3GNT3, FUT1, ST3GAL6, ST3GAL3, B4GALT4, B3GNT2",1.14813039927023,0.401209493236885,FALSE
+"H460","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.13232,0.468,1,3367,0.999,"PIGF, PIGB, DPM2, PIGH, PIGO, PIGW",0,0.000434511774017692,FALSE
+"H460","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.59993,2.17,0.0123,2690,0.0715,"MTHFD2L, CS, MTHFD1, PGP, MDH2, AFMID, MTHFD2, ACO2",1.9100948885606,1.14569395819892,TRUE
+"H460","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31803,-1.1,0.314,14994,0.619,"PLA2G12A, LHB, CACNA1D, GNRH1, MAP3K3, MAPK11, CALML6, GNRHR, SOS1, CALM3, MAPK10, RAF1, MAP3K4, KRAS, ITPR2, HBEGF, MAPK13, MMP2, JUN, PRKACA, MAP3K2, NRAS, MAPK3, MAPK1, CDC42, MAPK14, PLA2G6, MAPK8, ADCY6, SOS2, MAP3K1, MMP14",0.503070351926785,0.208309350979882,FALSE
+"H460","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.34229,1.22,0.195,12576,0.335,"IL6, IL1A, FAS, CD86, CD80, PRF1, IFNG, KIR2DL1, KIR3DL2, IL2, CD28, KIR3DL1, KIR2DL3, GZMB, FASLG, KLRC1, KLRD1, IL1B, TNF",0.709965388637482,0.474955192963155,FALSE
+"H460","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.30046,-1.04,0.349,12943,0.6,"WNT8B, WNT6, WNT16, PTCH1, PTCH2, HHIP, WNT7A, WNT5B, WNT4, BMP8A, CSNK1G2, FBXW11, STK36, WNT2B, WNT10A, BMP7, CSNK1G1, SUFU, CSNK1A1, GSK3B, RAB23, WNT9A, PRKACA, BMP4, CSNK1E, WNT7B",0.45717457304082,0.221848749616356,FALSE
+"H460","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.26207,-0.911,0.564,11009,0.738,"CD19, GP5, CD3D, CD1D, CD33, CD38, CD7, IL11RA, CD36, CD44, THPO, CD34, IL1B, TNF, CD4, ITGAM, CD8A, IL1R2, GP1BA, FCGR1A, KIT, IL3RA, CSF1R, CSF2, ITGA1, ITGA4, CD9, ANPEP, CD22, IL7, IL7R, ITGB3, EPOR, IL11, MME, ITGA2, IL4R, CD59, FLT3LG, ITGA3",0.248720896016658,0.131943638176958,FALSE
+"H460","Input","KEGG_HISTIDINE_METABOLISM",0.45304,1.6,0.0786,1779,0.179,"ALDH3A1, BUD23, ALDH9A1, AMDHD1, ALDH3A2, ALDH3B1, ALDH1B1",1.10457745396059,0.747146969020107,FALSE
+"H460","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.4106,1.46,0.0941,3688,0.227,"XRCC3, RAD51D, POLD2, RAD51B, RPA4, SSBP1, XRCC2, RAD51C, RPA2, POLD1, EME1, SEM1, RPA1",1.02641037657274,0.643974142806877,FALSE
+"H460","Input","KEGG_HUNTINGTONS_DISEASE",0.40269,1.46,0.0839,3200,0.227,"ATP5F1B, NDUFB10, SLC25A6, CASP9, NDUFS2, ATP5MC1, VDAC1, UQCRC2, SLC25A5, ATP5MC3, POLR2C, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, POLR2D, VDAC2, NDUFB8, COX7C, SOD1, NDUFA5, POLR2L, NDUFA1, PLCB1, COX5A, PPID, TFAM, COX7B, POLR2J3, ITPR1, NDUFB3, UQCRQ, POLR2I, NDUFB1, COX5B, CASP8, NDUFS6, BDNF, SDHC, ATP5F1A, CREB1, UQCRHL, AP2B1, SDHB, ATP5F1C, NDUFS7, POLR2A, DNAL1, NDUFV3, ATP5MC2, ATP5F1D, NDUFS4, VDAC3, NDUFA7, NDUFC1, POLR2E, COX6A1, COX6B1, UQCRH, CYCS, SDHD, NDUFS5",1.0762380391713,0.643974142806877,FALSE
+"H460","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.20689,-0.709,0.875,10525,0.951,"CACNB1, CACNG8, MYL3, CACNG1, ACTC1, CACNA2D2, TNNI3, IGF1, MYL2, SGCG, CACNG6, SGCA, DAG1, SGCD, ITGB8, CACNG7, ITGA11, TNF, LAMA2, ITGA9, ITGB7, CACNA2D4, TNNT2, ITGA10, ITGA1, TPM4, CACNA1D, CACNB4, ITGA4, ACE, ITGB1, PRKAA1, CACNB3, TNNC1, ITGB6, ITGB3, ITGB4, PRKAB1, ITGAV, ITGA7, ITGA2, TPM1, ITGA3",0.0579919469776868,0.0218194830625861,FALSE
+"H460","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.38151,-1.34,0.128,16073,0.383,"PLCG1, PIP5K1C, PIP4K2A, INPP1, PIK3CD, INPPL1, INPP4B, INPP5J, SYNJ2, SYNJ1, ALDH6A1, PIK3C2A, PLCD1, INPP5B, ISYNA1, PIK3CA",0.892790030352132,0.416801226031377,FALSE
+"H460","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.28842,-1.02,0.413,15520,0.61,"PPP1CA, INPP5K, CBLC, CALML6, PRKAA1, PTPRF, SOS1, TSC1, CALM3, MAPK10, SHC2, PRKAB1, RAF1, GSK3B, CRKL, SOCS1, KRAS, PIK3CD, LIPE, RPS6KB2, PIK3R3, PPP1CB, PRKACA, SORBS1, AKT2, NRAS, BRAF, MAPK3, CBLB, INSR, MKNK1, MAPK1, PTPN1, CBL, MAPK8, SOS2, PRKCI, PHKG1, PIK3CA",0.384049948343599,0.214670164989233,FALSE
+"H460","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.1641,-0.566,0.993,13425,1,"TNFSF13, CXCL12, ITGB7, MADCAM1, ITGA4, CXCR4, CCL28",0.00305075150461883,0,FALSE
+"H460","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.30244,-1.04,0.371,13730,0.6,"PIK3CB, IL13, IL2RG, SPRED1, IL3RA, PIK3R1, CLCF1, CCND2, SPRED2, IL20RA, CSF2, CCND1, JAK2, IL20RB, STAM, CISH, STAM2, CBLC, IL23A, PIAS2, IFNAR2, TYK2, JAK1, IL7, IL7R, SPRY2, SOS1, IL10RB, EPOR, STAT5A, PIM1, SOCS5, IL11, SOCS1, PIK3CD, PIK3R3, IL6ST, AKT2, EP300, PIAS1, IFNGR2, CBLB, SPRY1, CREBBP, IFNGR1, IL4R, CBL, BCL2L1, SOS2, STAT3, IRF9, STAT2, PIK3CA",0.430626090384954,0.221848749616356,FALSE
+"H460","Input","KEGG_LEISHMANIA_INFECTION",-0.4185,-1.45,0.0759,14672,0.397,"JAK2, NCF2, TLR2, TLR4, ITGA4, MAPK11, ITGB1, IRAK4, ITGB2, JAK1, MAPK13, JUN, RELA, MAP3K7, IFNGR2, MAPK3, MARCKSL1, MAPK1, IFNGR1, MAPK14, TRAF6, TAB2",1.11975822410452,0.401209493236885,FALSE
+"H460","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.39162,-1.37,0.0968,12132,0.412,"NCF1, PIK3R2, CLDN14, VAV2, PECAM1, CDH5, CLDN7, VCAM1, CLDN23, CLDN10, CLDN3, ITGAM, MMP9, CYBB, VAV3, ROCK2, CXCL12, ACTN4, PIK3CB, VAV1, PRKCG, JAM2, PIK3R1, CTNNB1, NCF2, PXN, CLDN9, MYLPF, THY1, ITGA4, CXCR4, MAPK11, ITGB1, ITGB2, F11R, VASP, PLCG1, MYL9, ESAM, SIPA1, PTK2, GNAI3, MYL12A, AFDN, MYL12B, PIK3CD, MAPK13, MMP2, PIK3R3, RAC1, RASSF5, ROCK1, RAC2, ARHGAP35, CTNND1, CDC42, ICAM1, MAPK14, ARHGAP5, RAP1A, OCLN, BCAR1, PIK3CA",1.01412464269161,0.385102783966865,FALSE
+"H460","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.70752,2.55,0,1898,0.0801,"ALDH9A1, ECHS1, ALDH3A2, ALDH1B1, HADHA",Inf,1.09636748391576,TRUE
+"H460","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.31205,1.16,0.235,292,0.362,"AKR1B10, PLA2G4A",0.628932137728264,0.441291429466834,FALSE
+"H460","Input","KEGG_LONG_TERM_DEPRESSION",-0.20412,-0.711,0.88,14374,0.96,"GNAO1, CACNA1A, GNAQ, GNA13, PLA2G12A, PPP2CB, RAF1, GNAI3, PPP2R1A, KRAS, ITPR2, NRAS, BRAF, MAPK3, MAPK1, PLA2G6",0.0555173278498314,0.0177287669604316,FALSE
+"H460","Input","KEGG_LONG_TERM_POTENTIATION",-0.31608,-1.1,0.298,16365,0.619,"CALM3, RAF1, PPP3CB, KRAS, ITPR2, PPP3CA, PPP1CB, PRKACA, NRAS, BRAF, EP300, MAPK3, RPS6KA2, MAPK1, CREBBP, RAP1A",0.525783735923745,0.208309350979882,FALSE
+"H460","Input","KEGG_LYSINE_DEGRADATION",0.34846,1.25,0.169,3207,0.335,"ALDH9A1, SUV39H1, SETD7, AADAT, DLST, HADH, ECHS1, ALDH3A2, ALDH1B1, HADHA, ACAT1, OGDH, PLOD3, KMT5A, ASH1L, TMLHE",0.772113295386326,0.474955192963155,FALSE
+"H460","Input","KEGG_LYSOSOME",-0.30037,-1.04,0.354,13756,0.6,"AP1S2, PLA2G15, AP3D1, M6PR, LAMP1, DNASE2, CTSA, MCOLN1, CTSK, LAPTM4A, IDUA, NPC1, ACP5, AP3M2, LAPTM5, LAMP2, LAMP3, GNPTG, CLTCL1, CTSO, HEXA, SUMF1, SCARB2, FUCA1, SMPD1, GLB1, SLC17A5, AP1G1, PSAP, AP3S1, ARSA, ACP2, HGSNAT, ENTPD4, CTSB, CTSS, CTSV, MAN2B1, MANBA, MFSD8, NEU1, ATP6V1H, NPC2, CTSH, CD164, SORT1, TPP1",0.450996737974212,0.221848749616356,FALSE
+"H460","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.29299,-1.02,0.392,15225,0.61,"MAP3K11, RASA1, CACNA1D, CACNB4, RASGRP3, RASGRF1, HSPB1, MAP3K3, STK3, MAPK8IP2, FGF1, MAPK11, CACNB3, TAOK1, RRAS, SOS1, DUSP16, FGFR2, MAPK10, GADD45A, NTF4, ATF2, FLNC, RAF1, PTPRR, PPP3CB, MAP3K4, CRKL, MAP3K6, KRAS, PAK2, MAPK13, DUSP8, JUN, PPP3CA, DDIT3, RAC1, PRKACA, FGF11, MAP3K2, AKT2, NRAS, RELA, BRAF, MAP3K7, RAC2, MAPK3, PPM1A, RPS6KA2, MKNK1, MAPK1, CDC42, STMN1, MRAS, MAPKAPK2, NLK, MAPK14, PDGFB, MAPK8IP1, SRF, PLA2G6, MECOM, RAP1A, RASA2, MAPK8, TGFBR2, DUSP10, TRAF6, LAMTOR3, SOS2, MAP4K3, RELB, MAP3K1, PPM1B, TAB2",0.406713932979543,0.214670164989233,FALSE
+"H460","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.21355,-0.75,0.822,11298,0.92,"PDX1, HNF1A, HNF4A, MAFA, GCK, FOXA3, HNF1B, NR5A2, FOXA2, HES1",0.0851281824599496,0.0362121726544447,FALSE
+"H460","Input","KEGG_MELANOGENESIS",-0.26768,-0.914,0.534,12802,0.742,"CAMK2A, CREB3L2, WNT8B, WNT6, WNT16, ADCY4, FZD1, WNT7A, WNT5B, KIT, PRKCG, CREB3L4, CTNNB1, ADCY5, WNT4, GNAO1, GNAQ, CREB3, WNT2B, WNT10A, CALML6, LEF1, TCF7, CALM3, FZD2, CREB3L1, RAF1, FZD6, GNAI3, GSK3B, KRAS, WNT9A, PRKACA, NRAS, EP300, MAPK3, WNT7B, MAPK1, TCF7L1, CREBBP, ADCY6, DVL3",0.272458742971444,0.129596094720973,FALSE
+"H460","Input","KEGG_MELANOMA",-0.27922,-0.96,0.474,11042,0.685,"FGF7, PIK3CG, FGF8, HGF, IGF1, MET, FGF22, AKT3, FGF17, FGF21, MITF, PIK3R2, FGF9, RB1, FGF18, MDM2, PIK3CB, E2F3, PDGFRA, EGFR, PDGFA, PIK3R1, CCND1, FGF5, PDGFC, PDGFD, FGF1, RAF1, KRAS, PIK3CD, CDH1, PIK3R3, FGF11, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, PDGFB, PIK3CA",0.324221658325915,0.164309428507574,FALSE
+"H460","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.43887,1.61,0.0408,2218,0.185,"ALDH3A1, GSTM1, AKR1C2, AKR1C1, EPHX1, AKR1C3, CYP1B1, GSTM3, GSTO2, MGST1, ALDH3B1, GSTM4, GSTO1, MGST2",1.38933983691012,0.732828271596986,TRUE
+"H460","Input","KEGG_MISMATCH_REPAIR",0.64874,2.31,0.00573,2985,0.0539,"EXO1, RFC2, POLD2, RFC5, RPA4, SSBP1, LIG1, PCNA, RFC3, RPA2, POLD1",2.24184537803261,1.26841123481326,TRUE
+"H460","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38178,-1.32,0.125,15817,0.374,"PRKAA1, TSC1, HIF1A, CAB39L, PIK3CD, RPS6KB2, PIK3R3, AKT2, CAB39, BRAF, MAPK3, RPS6KA2, MAPK1, VEGFA, VEGFB, RICTOR, PIK3CA",0.903089986991944,0.42712839779952,FALSE
+"H460","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.30396,-1.05,0.367,12133,0.636,"PIK3R2, PPP3R2, SH2D1B, VAV2, CHP1, TNF, ULBP2, TNFRSF10D, NFATC2, KLRC3, ULBP1, KLRK1, VAV3, LCK, LAT, PIK3CB, VAV1, KLRC2, PRKCG, PIK3R1, RAET1L, CSF2, ICAM2, HCST, SYK, ITGB2, IFNAR2, PLCG1, SOS1, SHC2, RAF1, PPP3CB, KRAS, PIK3CD, TNFSF10, PIK3R3, PPP3CA, RAC1, NRAS, BRAF, IFNGR2, RAC2, MAPK3, MAPK1, IFNGR1, ICAM1, SH3BP2, SOS2, NFAT5, FYN, PIK3CA",0.435333935747911,0.196542884351586,FALSE
+"H460","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.13822,-0.478,0.998,8151,0.999,"NPY2R, GABRG1, TAAR1, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CRHR2, PRL, GPR83, P2RY10, P2RY4, HTR4, GABRB3, HCRTR1, APLNR, GRM1, P2RX3, TSHB, ADRA1A, HCRTR2, CCKAR, GABRA4, GLP1R, GPR50, CALCR, S1PR4, HTR2B, RXFP1, TRHR, HRH3, NR3C1, CHRNA4, MC5R, DRD5, CHRNB2, CCKBR, FPR2, HTR1F, AVPR1A, FPR3, GABRB2, GRM7, P2RX7, AVPR1B, TACR3, THRA, HTR2A, NPY5R, GRM5, NMUR2, F2, P2RY8, ADCYAP1R1, CGA, CHRNB4, PTGER2, CYSLTR1, GRIA1, GABRG3, UTS2R, NPFFR1, CHRM2, GRM3, GRIN2C, P2RX1, LPAR6, GHSR, GRIN2D, P2RY13, GABRA2, GHRHR, GABRR1, SSTR2, GABRD, F2RL3, CHRNA1, CHRM1, GABRB1, GRIK3, CRHR1, ADORA3, PTGER3, GABRA5, PRSS1, GRIA3, MCHR2, CHRNA9, CHRNA3, CALCRL, MCHR1, PTGER1, GRM2, GRM8, P2RX2, GRIA2, EDNRB, GRID2, DRD1, CTSG, GRM4, HRH2, GRIA4, PRSS2, PTGIR, KISS1R, PLG, LPAR4, AGTR1, OPRD1, GRIN2A, GABRP, GRIN2B, SSTR1, P2RY14, PTH2R, ADRA2B, LPAR3, NPY1R, CNR1, DRD2, NPFFR2, ADRA2A, GABRG2, NPBWR1, TRPV1, FPR1, GRIK5, GRID1, HTR2C, PTGER4, OXTR, GALR3, PRLR, NMBR, GRIK4, GRIN1, GABRQ, HRH1, P2RY6, PTGFR, EDNRA, NPY4R, GRPR, GRIN3B, C3AR1, GPR156, ADRA1B, CHRNA10, CHRNE, GPR35, TACR2, CHRM4, GABRR2, LHB, GRIK2, GIPR, PRSS3, PTAFR, BDKRB1, S1PR1, HTR7, CHRM3, OPRL1, DRD4, GABRA3, P2RY2, GNRHR, ADORA2B, F2R, BDKRB2, VIPR1, P2RX4, ADORA2A, ADRB2, ADORA1, THRB, LPAR1, CHRNB1, P2RY11, F2RL1, S1PR2, LPAR2",0.000869458712628891,0.000434511774017692,FALSE
+"H460","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.40897,-1.4,0.0894,15435,0.417,"NGFR, MAP3K3, MAPK11, IRAK4, CALML6, PSEN1, PLCG1, SOS1, CALM3, MAPK10, FRS2, SHC2, NTF4, RAF1, GSK3B, CRKL, KRAS, PIK3CD, MAPK13, JUN, TP73, PIK3R3, RAC1, AKT2, NRAS, RELA, BRAF, NFKBIE, MAPK3, RPS6KA2, MAPK1, CDC42, MAPKAPK2, MAPK14, GAB1, ARHGDIB, RAP1A, MAPK8, TRAF6, YWHAZ, SOS2, MAP3K1, PIK3CA, SORT1, FOXO3",1.04866248120408,0.379863945026242,FALSE
+"H460","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.35394,1.24,0.177,1786,0.332,"NAMPT, PNP, NT5M, NT5C, BST1",0.752026733638193,0.478861916295964,FALSE
+"H460","Input","KEGG_NITROGEN_METABOLISM",0.29713,1.06,0.332,887,0.458,"CPS1, CA12",0.478861916295964,0.339134521996131,FALSE
+"H460","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.30548,-1.08,0.328,16420,0.622,"MAPK10, TAB3, BIRC3, MAPK13, CASP1, RELA, MAP3K7, PYCARD, MAPK3, BIRC2, MAPK1, NLRP1, ERBIN, MAPK14, MAPK8, TRAF6, TAB2",0.484126156288321,0.206209615309181,FALSE
+"H460","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.36945,-1.25,0.169,16071,0.424,"MRE11, LIG4, POLM, DCLRE1C",0.772113295386326,0.372634143407267,FALSE
+"H460","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.4574,-1.58,0.0432,16073,0.462,"PLCG1, SOS1, FHIT, RAF1, KRAS, PIK3CD, PIK3R3, RASSF5, AKT2, NRAS, BRAF, MAPK3, MAPK1, CDKN2A, TGFA, SOS2, RXRB, PIK3CA, FOXO3",1.36451625318509,0.335358024443874,FALSE
+"H460","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.4997,-1.72,0.0245,15409,0.311,"MAML2, NOTCH2, DLL1, RBPJ, MFNG, PSEN1, NUMB, KAT2B, DTX3L, DTX4, EP300, JAG1, MAML1, CREBBP, LFNG, RFNG, DVL3, HES1, CIR1, HDAC1, DTX2",1.61083391563547,0.507239610973163,FALSE
+"H460","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.39236,1.44,0.0823,3841,0.224,"GTF2H2, POLE3, RFC2, CUL4A, POLD2, RFC5, RPA4, POLE2, CCNH, ERCC8, LIG1, PCNA, RFC3, CDK7, RPA2, POLE, POLD1, XPA, GTF2H3, ERCC3, RAD23B, RPA1, XPC",1.08460016478773,0.649751981665837,FALSE
+"H460","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.23208,-0.806,0.746,15016,0.861,"MAN2A2, ALG2, ALG8, MAN1C1, MGAT3, ALG6, ALG11, FUT8, DDOST, MGAT5B, MGAT4A, MAN1A1, MAN1A2",0.127261172527331,0.0649968485463452,FALSE
+"H460","Input","KEGG_OLFACTORY_TRANSDUCTION",0.2195,0.764,0.747,11747,0.836,"PDE1C, CALM1, ARRB2, ADCY3, PRKX, OR6A2, OR10AD1, OR10A2, GNAL, CAMK2D, OR1F1, CALM2, OR1L8, OR2AT4, PRKG2, OR2AG1, OR7C1, PRKACB, OR1Q1, OR6C6, OR52J3, OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR52D1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR13J1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR2AE1, OR5AK2, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2H2, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, CNGA3, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR7D2, OR1B1, OR2L3, OR8D1, OR51E2, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, OR13D1, OR8D2, OR2T33, OR1J2, OR2S2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, CALML3, OR4D1, OR2C1, OR8G1, CALML5, OR4F15, OR52B6, OR2A25, OR2D3, OR10H1, OR8A1, OR2B2, OR1K1, OR56B4, OR2J3, OR10A6, OR2A2, OR1J1, OR8G5, OR4F3, OR11H4, OR10A4, GUCY2D, OR51B4, OR13A1, OR6B2, OR2A12, OR2D2, OR10A3, OR2K2, PRKG1, CNGB1, OR13H1, OR2A14",0.126679398184601,0.0777937225609836,FALSE
+"H460","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.50003,1.78,0.0442,3512,0.131,"MTHFD2L, MTFMT, ATIC, MTHFD1, SHMT2, SHMT1, MTHFD2, MTHFS, MTR, DHFR",1.35457773065091,0.882728704344236,TRUE
+"H460","Input","KEGG_OOCYTE_MEIOSIS",0.22185,0.796,0.715,2884,0.794,"YWHAE, ADCY7, ANAPC1, ANAPC5, CALM1, AR, ANAPC7, MAPK12, SMC1A, ITPR1, YWHAG, PTTG1, AURKA, ADCY3, PLK1, PRKX, CDC26, CCNB1, BUB1, PKMYT1, CUL1, CDK1, PPP2R5C, PPP2R1B, PPP2CA, PPP1CC, CAMK2D, SLK, SMC3",0.145693958198919,0.100179497572904,FALSE
+"H460","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.55136,-1.91,0.0147,15891,0.404,"HEXA, FUCA1, GLB1, MAN2B2, MAN2B1, MANBA, NEU1",1.83268266525182,0.393618634889395,FALSE
+"H460","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.46153,1.7,0.0288,3200,0.157,"ATP5F1B, NDUFB10, NDUFS2, ATP5MC1, COX10, UQCRC2, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, COX15, ATP5ME, NDUFB8, COX7C, COX11, PPA1, NDUFA5, NDUFA1, COX5A, COX7B, NDUFB3, UQCRQ, NDUFB1, COX5B, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, NDUFS7, NDUFV3, ATP6V0D1, ATP5MC2, ATP5F1D, NDUFS4, ATP6V0E2, NDUFA7, NDUFC1, COX6A1, COX6B1, ATP6AP1, UQCRH, PPA2, SDHD, NDUFS5",1.54060751224077,0.804100347590766,TRUE
+"H460","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.3466,1.23,0.209,1859,0.33,"GALNT16, GALNT13, GALNT14, ST3GAL1, C1GALT1C1, GALNT18, GALNT11",0.679853713888946,0.481486060122112,FALSE
+"H460","Input","KEGG_P53_SIGNALING_PATHWAY",-0.25547,-0.88,0.604,13371,0.772,"ADGRB1, GADD45B, MDM2, CCNE2, DDB2, PMAIP1, CCND2, CCNE1, CCND1, SESN1, RRM2B, BBC3, SERPINE1, ATM, GADD45A, ZMAT3, APAF1, TP73, SESN2, CDKN2A, THBS1, SIAH1, CD82, CCNG2",0.218963061378868,0.112382699664264,FALSE
+"H460","Input","KEGG_PANCREATIC_CANCER",-0.44057,-1.53,0.0687,16420,0.396,"MAPK10, RAF1, KRAS, PIK3CD, RALB, PIK3R3, RAC1, AKT2, RELA, BRAF, RAC2, MAPK3, MAPK1, CDKN2A, CDC42, VEGFA, SMAD3, TGFA, RALA, BCL2L1, VEGFB, MAPK8, TGFBR2, STAT3, PIK3CA",1.16304326294045,0.402304814074488,FALSE
+"H460","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.38375,-1.34,0.123,10754,0.383,"DPYS, ENPP1, ENPP3, UPB1, VNN2, VNN1, PANK4, PANK3, PPCS, DPYD",0.910094888560602,0.416801226031377,FALSE
+"H460","Input","KEGG_PARKINSONS_DISEASE",0.55018,1.96,0.0182,3200,0.0925,"PRKN, ATP5F1B, NDUFB10, SLC25A6, SNCA, CASP9, NDUFS2, ATP5MC1, VDAC1, UQCRC2, SLC25A5, ATP5MC3, NDUFA10, NDUFS1, NDUFAB1, NDUFA8, UCHL1, VDAC2, NDUFB8, COX7C, NDUFA5, NDUFA1, COX5A, PPID, COX7B, NDUFB3, UQCRQ, NDUFB1, COX5B, HTRA2, NDUFS6, SDHC, ATP5F1A, UQCRHL, SDHB, ATP5F1C, NDUFS7, NDUFV3, UBB, ATP5MC2, ATP5F1D, NDUFS4, UBA1, VDAC3, NDUFA7, NDUFC1, COX6A1, COX6B1, PARK7, UQCRH, CYCS, SDHD, NDUFS5",1.73992861201493,1.03385826726097,TRUE
+"H460","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.25758,0.934,0.469,4082,0.611,"NCL, ARHGEF2, TUBB4A, HCLS1, TUBA1B, CD14, TUBB3, TUBA1A, ARPC5L, TUBA4A, RHOA, TUBAL3, TUBB4B, TUBA1C, TUBB2B, EZR, TUBB2A, KRT18, ACTG1, ACTB, TUBA3D, TUBB6, ABL1",0.328827157284917,0.213958789757446,FALSE
+"H460","Input","KEGG_PATHWAYS_IN_CANCER",-0.29691,-1.04,0.367,16043,0.6,"JAK1, FADD, PLCG1, LEF1, TCF7, SOS1, LAMC2, HIF1A, DAPK2, FGFR2, DAPK3, RARA, FZD2, MAPK10, NCOA4, PTK2, SUFU, RUNX1, ELOC, RBX1, APC, RAF1, ITGAV, FZD6, STAT5A, ARNT2, LAMA4, GSK3B, CRKL, KRAS, PIK3CD, BIRC3, CDH1, MMP2, WNT9A, CUL2, RALB, JUN, PIK3R3, CDKN2B, RAC1, RASSF5, FGF11, ITGA2, AKT2, NRAS, RELA, BRAF, BMP4, EP300, PIAS1, RAC2, MAPK3, BIRC2, CBLB, WNT7B, MAPK1, CDKN2A, CDC42, TCF7L1, CREBBP, DAPK1, VEGFA, EGLN2, SMAD3, PDGFB, TGFA, CBL, MECOM, RALA, FLT3LG, BCL2L1, ITGA3, VEGFB, MAPK8, TGFBR2, TRAF6, SOS2, DVL3, PPARD, HDAC1, STAT3, RXRB, PIK3CA, CDKN1B",0.435333935747911,0.221848749616356,FALSE
+"H460","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.35682,1.28,0.138,1865,0.328,"UGDH, RPE, DCXR",0.860120913598763,0.484126156288321,FALSE
+"H460","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.5638,2,0.0126,2290,0.108,"G6PD, PGD, TKT, PRPS1, TALDO1, ALDOA, PFKM, PRPS2, GPI, RPE, PFKP, RPIA",1.89962945488244,0.96657624451305,TRUE
+"H460","Input","KEGG_PEROXISOME",-0.30624,-1.08,0.312,16111,0.622,"ACOX1, PEX7, XDH, PAOX, ACSL5, IDH2, PRDX5, PEX11G, PEX5, MLYCD, FAR2, ACOX3, ACOT8, PEX2, HMGCL, SCP2, CAT",0.505845405981557,0.206209615309181,FALSE
+"H460","Input","KEGG_PHENYLALANINE_METABOLISM",0.56433,1.96,0.0211,1596,0.0925,"ALDH3A1, GOT2, HPD, PRDX6, AOC3, ALDH3B1",1.67571754470231,1.03385826726097,TRUE
+"H460","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.31731,-1.09,0.322,15535,0.628,"INPP5K, CALML6, PLCG1, PIP5K1C, CALM3, PIP4K2A, INPP1, PIK3CD, ITPR2, PIK3R3, DGKA, INPPL1, INPP4B, INPP5J, CDS1, SYNJ2, SYNJ1, CDS2, DGKH, PIK3C2A, PLCD1, INPP5B, PIK3CA",0.492144128304169,0.202040356262804,FALSE
+"H460","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.52074,1.82,0.0312,1873,0.119,"COX10, EARS2, HCCS, COX15, MMAB, BLVRB, FECH, BLVRA, UROD",1.50584540598156,0.924453038607469,TRUE
+"H460","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.23813,-0.825,0.679,15730,0.833,"ACAA1, CYP27A1, ACOX1, ACSL5, SLC27A1, SORBS1, PPARA, CPT1B, ILK, ACOX3, SCP2, PPARD, RXRB",0.168130225719498,0.0793549985932124,FALSE
+"H460","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.28596,1.02,0.391,1362,0.514,"SLC27A5, ACOX2, CYP39A1",0.407823242604133,0.289036881004724,FALSE
+"H460","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.18797,-0.649,0.94,10646,0.977,"CD79A, ZAP70, CD19, CD3D, IGLL1, JAK3, CD4, CD8A, CIITA, LCK, RFXAP, BLNK, IL2RG, RAG1, IL7R, RFXANK, DCLRE1C",0.0268721464003014,0.0101054362812269,FALSE
+"H460","Input","KEGG_PRION_DISEASES",0.30639,1.1,0.291,2117,0.425,"SOD1, HSPA5, IL6, LAMC1, NCAM2, HSPA1A, PRKX, STIP1",0.536107011014093,0.371611069949688,FALSE
+"H460","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.27052,0.996,0.414,2295,0.548,"PDE3A, HSP90AA1, PDE3B, HSP90AB1, ADCY7, ANAPC1, ANAPC5, ANAPC7, CDC25A, MAPK12, ARAF, AKT1, ADCY3, PLK1, PRKX, CDC26, CCNB1, BUB1, PKMYT1, CDK1, MAPK9",0.382999658879101,0.261219441515631,FALSE
+"H460","Input","KEGG_PROPANOATE_METABOLISM",0.45661,1.65,0.0447,2859,0.172,"ALDH9A1, ACSS3, SUCLG1, MCEE, ECHS1, ALDH3A2, ALDH1B1, HADHA, LDHA, ACAT1, ACACA, HIBCH, LDHB",1.34969247686806,0.764471553092451,TRUE
+"H460","Input","KEGG_PROSTATE_CANCER",-0.33808,-1.16,0.258,13607,0.535,"MDM2, PIK3CB, E2F3, PDGFRA, CCNE2, CREB3L4, EGFR, NFKBIA, PDGFA, PIK3R1, CTNNB1, ERBB2, CCNE1, CCND1, CREB3, PDGFC, PDGFD, LEF1, TCF7, SOS1, FGFR2, CREB3L1, RAF1, GSK3B, KRAS, PIK3CD, PIK3R3, AKT2, NRAS, RELA, BRAF, EP300, MAPK3, MAPK1, TCF7L1, CREBBP, PDGFB, TGFA, SOS2, PIK3CA, CDKN1B",0.58838029403677,0.271646217978772,FALSE
+"H460","Input","KEGG_PROTEASOME",0.66446,2.45,0.0069,3881,0.0822,"PSMB10, PSMB5, PSMA3, PSMD4, PSMD11, PSMC1, PSME3, PSMD14, PSMB6, PSMD1, PSMA6, PSMA4, PSMC5, PSMB4, POMP, PSMD7, PSMB7, PSMB3, PSMD12, PSMA7, PSMF1, PSMC6, PSMC2, PSMC4, PSMD3, PSMB8, SEM1, PSMB9, PSME2, PSMA1",2.16115090926274,1.08512818245995,TRUE
+"H460","Input","KEGG_PROTEIN_EXPORT",0.21314,0.755,0.804,2667,0.842,"HSPA5, OXA1L, SRP68, SRP19, SPCS1, SEC11A",0.0947439512515487,0.0746879085003505,FALSE
+"H460","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23093,-0.801,0.726,8788,0.859,"ATP1A2, ATP1B4, ATP1A4, CA4, MDH1, PCK1, GLS, FXYD2, ATP1B2, SLC38A3, GLUD1, AQP1, GLS2, PCK2, ATP1A1, SLC4A4, GLUD2",0.139063379299906,0.0660068361687577,FALSE
+"H460","Input","KEGG_PURINE_METABOLISM",0.50449,1.83,0.0282,3031,0.122,"PDE1A, PDE3A, GDA, PDE10A, PNPT1, PDE7B, PDE4D, POLR3K, NPR1, PFAS, POLR3G, PAPSS2, POLR2C, PDE3B, PRPS1, POLE3, NME1, ADCY7, IMPDH1, PNP, NT5M, POLR2D, ATIC, PRIM1, PDE4B, NT5C, PDE8B, PDE1C, PRPS2, NME2, POLA1, RRM2, POLR2L, NME4, HPRT1, AK2, POLD2, DGUOK, POLR2J3, POLE2, IMPDH2, ADCY3, POLR3B, NME3, GUK1, POLR2I, POLR1B, ADSL, POLR3D, NUDT9, ENTPD6, POLR1E, PAICS, POLR2A, POLR3GL, ITPA, POLR3A, NME5, PPAT, POLR2E, POLE, POLD1, POLR1A, PDE4A",1.54975089168064,0.913640169325252,TRUE
+"H460","Input","KEGG_PYRIMIDINE_METABOLISM",0.49961,1.77,0.042,3137,0.129,"UCK2, PNPT1, POLR3K, POLR3G, POLR2C, TXNRD1, DHODH, POLE3, NME1, PNP, NT5M, POLR2D, PRIM1, NT5C, DTYMK, NME2, POLA1, RRM2, CAD, POLR2L, NME4, POLD2, CTPS1, POLR2J3, POLE2, POLR3B, NME3, POLR2I, POLR1B, POLR3D, ENTPD6, POLR1E, POLR2A, POLR3GL, ITPA, POLR3A, NME5, POLR2E, POLE, POLD1, POLR1A, TXNRD2, NT5C3A",1.3767507096021,0.889410289700751,TRUE
+"H460","Input","KEGG_PYRUVATE_METABOLISM",0.53128,1.9,0.0132,3525,0.102,"PDHA1, ALDH9A1, ME1, HAGHL, DLD, ACYP1, DLAT, ME2, MDH2, ALDH3A2, ALDH1B1, LDHA, ACAT1, ACACA, LDHB, AKR1B1, PDHB, PKM, LDHD, GRHPR",1.87942606879415,0.991399828238082,TRUE
+"H460","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.33182,-1.14,0.276,13444,0.562,"VAV3, ROCK2, ARPC3, IQGAP2, ACTN4, PIK3CB, VAV1, ITGB7, PDGFRA, ITGAX, EGFR, PDGFA, PIK3R1, MYH9, RRAS2, FGF5, CHRM4, ITGA10, ITGA1, PXN, APC2, GNA13, MYLPF, MYLK2, PAK4, PDGFC, BDKRB1, ITGA4, CHRM3, PPP1CA, PDGFD, FGF1, ITGB1, ITGB2, RRAS, SOS1, MYL9, ITGB6, ITGB3, PIP5K1C, FGFR2, PIP4K2A, F2R, BDKRB2, ITGB4, PTK2, TIAM1, APC, SSH2, RAF1, ITGAV, ITGA7, MYL12A, CRKL, MYL12B, KRAS, PIK3CD, PAK6, PAK2, CFL1, BAIAP2, PIK3R3, RAC1, PPP1CB, FGF11, ITGA2, NRAS, BRAF, ROCK1, RAC2, ARHGAP35, MAPK3, ARHGEF7, BRK1, MAPK1, CDC42, MRAS, WASF2, PDGFB, ARHGEF12, MYLK, PFN4, ITGA3, SOS2, BCAR1, GSN, TIAM2, PIK3CA",0.559090917934782,0.250263684430939,FALSE
+"H460","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.18999,-0.655,0.93,15784,0.982,"ATG12, PRKAA1, ATG5, GABARAP, GABARAPL2",0.0315170514460649,0.00788851221305034,FALSE
+"H460","Input","KEGG_RENAL_CELL_CARCINOMA",-0.5016,-1.75,0.0164,16164,0.473,"SOS1, FLCN, HIF1A, ELOC, RBX1, RAF1, ARNT2, CRKL, KRAS, PIK3CD, PAK6, PAK2, CUL2, JUN, PIK3R3, RAC1, AKT2, NRAS, BRAF, EP300, MAPK3, MAPK1, CDC42, CREBBP, VEGFA, EGLN2, PDGFB, TGFA, GAB1, RAP1A, VEGFB, SOS2, PIK3CA",1.7851561519523,0.325138859262188,FALSE
+"H460","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.25803,0.926,0.494,1166,0.609,"NLN, THOP1",0.306273051076353,0.215382707367125,FALSE
+"H460","Input","KEGG_RETINOL_METABOLISM",-0.17394,-0.607,0.978,8288,0.996,"ADH1B, RDH8, UGT2B4, ADH4, UGT2B17, CYP1A2, ADH1A, AWAT2, UGT2A3, CYP2C19, UGT2B15, CYP2A7, CYP2C9, CYP26C1, CYP26B1, CYP2B6, CYP2C18, CYP3A4, ADH1C, CYP4A22, CYP2A6, CYP2C8, LRAT, CYP26A1, ADH6, DHRS9, UGT2B7, RDH5, RDH16, BCO1, RETSAT, RDH12, CYP3A5, ALDH1A2, DGAT2, DHRS3, RDH10, CYP1A1, DGAT1",0.00966114521239857,0.00174066157630127,FALSE
+"H460","Input","KEGG_RIBOFLAVIN_METABOLISM",0.40671,1.48,0.0846,2443,0.232,"RFK, FLAD1, ACP1, PHPT1",1.07262963696098,0.6345120151091,FALSE
+"H460","Input","KEGG_RIBOSOME",0.60489,2.17,0.012,4206,0.0715,"RPS4Y1, RPS4X, RPL31, RPL22L1, RPL36AL, RPS23, RPS26, RPL38, RPL13, RPLP1, RPL23A, RPS2, RPL26L1, RPL3, RPL7A, RPL17, RPLP0, RPS29, RPL36A, RPS9, RPL35, RPS7, RPL27, RPS15A, RPL19, RPL26, RPL9, RPS15, RPS24, RPL14, RPL10, RPS27A, RPL23, RPL13A, RPL39, RPS21, RPS17, RPL4, RPL37A, RPS12, RPS10, RPL6, RPL29, RPL37, RPL36, RPL41, RPS27, RPL10A, RPS25, RPSA, RPL34, RPS27L, RPL12",1.92081875395238,1.14569395819892,TRUE
+"H460","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.30382,-1.04,0.368,15508,0.6,"AZI2, MAPK11, ATG12, IFIH1, TKFC, FADD, MAPK10, ATG5, MAPK13, RELA, IRF7, MAP3K7, MAPK14, ISG15, RIPK1, MAPK8, TRAF6, CYLD, MAP3K1",0.434152181326482,0.221848749616356,FALSE
+"H460","Input","KEGG_RNA_DEGRADATION",0.3458,1.25,0.162,1464,0.335,"HSPD1, PNPT1, HSPA9, EDC4, EXOSC2, MTREX, EXOSC8, ENO1, WDR61, EXOSC7, EXOSC1, CNOT1, EXOSC9",0.790484985457369,0.474955192963155,FALSE
+"H460","Input","KEGG_RNA_POLYMERASE",0.6485,2.33,0.00943,3017,0.0574,"POLR3K, POLR3G, POLR2C, POLR2D, POLR2L, POLR2J3, POLR3B, POLR2I, POLR1B, POLR3D, POLR1E, POLR2A, POLR3GL, POLR3A, POLR2E, POLR1A",2.02548830726267,1.24108810760203,TRUE
+"H460","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.55174,1.94,0.0155,1843,0.0941,"SCLY, BUD23, MARS2, PAPSS2, GGT1, AHCY, AHCYL2, MAT2A",1.80966830182971,1.02641037657274,TRUE
+"H460","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.27722,-0.968,0.469,15761,0.69,"ITGB1, TRAF1, PIAS2, LAMC2, PTK2, FHIT, ITGAV, LAMA4, PIK3CD, BIRC3, APAF1, PIK3R3, CDKN2B, ITGA2, AKT2, RELA, PIAS1, BIRC2, BCL2L1, ITGA3, TRAF6, RXRB, PIK3CA, CDKN1B",0.328827157284917,0.161150909262745,FALSE
+"H460","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.43415,-1.51,0.0556,17822,0.401,"SNAP29, SNAP23, VAMP5, STX7, VAMP3, TSNARE1, BET1, STX3, STX12, STX5",1.25492520841794,0.396855627379818,FALSE
+"H460","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2283,-0.799,0.744,12862,0.852,"DEGS2, ASAH1, SGPP2, GAL3ST1, SPHK1, ACER3, SPHK2, KDSR, SMPD3, CERK, PLPP3, SMPD1, GLB1, SGPL1, ARSA, SPTLC2, UGCG, NEU1",0.128427064454121,0.0695604052332999,FALSE
+"H460","Input","KEGG_SPLICEOSOME",0.43261,1.6,0.0467,3540,0.179,"SNRPF, HNRNPU, HNRNPM, SNRPB, PQBP1, HNRNPA3, PRPF4, HNRNPC, SRSF7, USP39, PRPF8, SNRPE, RBM8A, HSPA1A, HSPA8, HSPA1B, SNRPD3, PCBP1, HNRNPA1, ALYREF, SNRNP200, EIF4A3, SNRPG, SNRPA, SRSF1, CCDC12, PPIH, SRSF2, SRSF3, EFTUD2, SF3B4, U2AF2, SNRNP70, DDX46, ZMAT2, PHF5A, SNRPA1, SNRPD1, CTNNBL1, DDX23, LSM8, LSM6, HSPA6, TXNL4A, TCERG1, NCBP1, RBMX, HNRNPK, THOC3, PRPF6, LSM4, LSM7, PRPF40A, SRSF9, SNRPB2",1.33068311943389,0.747146969020107,TRUE
+"H460","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.21776,0.816,0.705,2120,0.774,"UGDH, PYGB, GPI, PYGL, GBE1",0.151810883008601,0.111259039317107,FALSE
+"H460","Input","KEGG_STEROID_BIOSYNTHESIS",-0.27849,-0.974,0.458,13959,0.688,"SQLE, CEL, MSMO1, SC5D, DHCR24, TM7SF2",0.339134521996131,0.162411561764489,FALSE
+"H460","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.2603,0.927,0.523,959,0.615,"AKR1C2, AKR1C1, AKR1C3, CYP1B1",0.281498311132726,0.211124884224583,FALSE
+"H460","Input","KEGG_SULFUR_METABOLISM",0.36449,1.3,0.161,1528,0.314,"PAPSS2, SULT1A4, SULT1A1",0.79317412396815,0.503070351926785,FALSE
+"H460","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.1358,0.476,1,1409,1,"SNRPB, SSB, SNRPD3",0,0,FALSE
+"H460","Input","KEGG_TASTE_TRANSDUCTION",-0.20982,-0.735,0.845,13045,0.934,"TAS2R13, ADCY4, GNG3, TAS2R3, KCNB1, TAS2R20, CACNA1A, TAS2R10, GNB1, TAS2R4, TAS2R46, TAS2R31, SCNN1A, TAS2R14, TAS2R19, PRKACA, TAS2R5, ADCY6",0.0731432910503077,0.0296531237699066,FALSE
+"H460","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.37443,-1.3,0.146,12475,0.379,"CDO1, GGT6, GGT5, ADO, CSAD, GGT7, GAD1",0.835647144215563,0.421360790031928,FALSE
+"H460","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.33549,1.2,0.203,4809,0.328,"PMVK, PDSS1, ACAT1, FDPS, MVK, IDI1, ACAT2, GGPS1",0.692503962086787,0.484126156288321,FALSE
+"H460","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.41502,-1.44,0.0756,15342,0.391,"BMP7, INHBE, INHBA, INHBB, PPP2CB, SMURF1, ID4, SP1, BMPR1B, ACVR1, RBX1, PPP2R1A, ACVR2B, RPS6KB2, CDKN2B, BMP4, EP300, ROCK1, RBL2, MAPK3, MAPK1, ACVR2A, CREBBP, SMAD3, LTBP1, THBS1, TGFBR2, ZFYVE9, SMAD7, BMPR2, SMURF2",1.12147820449879,0.407823242604133,FALSE
+"H460","Input","KEGG_THYROID_CANCER",-0.46805,-1.61,0.0334,14209,0.452,"CTNNB1, CCND1, TFG, LEF1, TCF7, NCOA4, KRAS, CDH1, NRAS, BRAF, MAPK3, MAPK1, TCF7L1, RXRB",1.47625353318844,0.344861565188618,FALSE
+"H460","Input","KEGG_TIGHT_JUNCTION",-0.29923,-1.03,0.371,13637,0.611,"MYH7B, ACTN4, MAGI3, EXOC4, IGSF5, PRKCD, PRKCG, YES1, PRKCZ, JAM2, PPP2R2A, CTNNB1, MYH9, MAGI2, PRKCQ, RRAS2, PPP2R2B, CLDN9, MYLPF, LLGL1, AMOTL1, TJP3, PPP2CB, EPB41L2, F11R, RRAS, MYL9, CTTN, MYH3, PRKCE, VAPA, GNAI3, MYL12A, PARD6A, AFDN, MYL12B, PPP2R1A, KRAS, CRB3, TJAP1, AKT2, NRAS, CGN, CDC42, MRAS, PARD6B, MAGI1, OCLN, PRKCI, CSNK2B, CSNK2A1",0.430626090384954,0.213958789757446,FALSE
+"H460","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.27974,-0.966,0.45,15735,0.683,"MAPK11, IRAK4, TLR5, LY96, IFNAR2, FADD, MAPK10, TICAM2, PIK3CD, MAPK13, JUN, PIK3R3, RAC1, AKT2, RELA, IRF7, MAP3K7, MAPK3, MAPK1, MAPK14, TOLLIP, RIPK1, MAPK8, TRAF6, PIK3CA, TAB2",0.346787486224656,0.165579296318467,FALSE
+"H460","Input","KEGG_TRYPTOPHAN_METABOLISM",0.35466,1.32,0.109,2420,0.301,"KYNU, ALDH9A1, TDO2, CYP1B1, AADAT, HADH, ECHS1, ALDH3A2, AFMID, ALDH1B1, HADHA, ACAT1, OGDH",0.962573502059376,0.521433504406157,FALSE
+"H460","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.37996,-1.31,0.134,11667,0.376,"ABCC8, CACNA1B, HK3, MAFA, GCK, PIK3R2, CACNA1G, KCNJ11, TNF, SLC2A4, PIK3CB, PRKCD, PRKCZ, PIK3R1, CACNA1A, CACNA1D, MAPK10, PRKCE, SOCS1, PIK3CD, PIK3R3, MAPK3, INSR, MAPK1, MAPK8, PIK3CA",0.872895201635192,0.424812155072339,FALSE
+"H460","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.31748,1.17,0.239,1387,0.356,"HSPD1, PTPRN",0.621602099051862,0.448550002027125,FALSE
+"H460","Input","KEGG_TYROSINE_METABOLISM",0.34995,1.24,0.183,2003,0.332,"ALDH3A1, GOT2, BUD23, HPD, AOC3, ALDH3B1, FAH",0.737548910269571,0.478861916295964,FALSE
+"H460","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.36309,-1.25,0.176,16073,0.424,"PLCG1, SOS1, NCK2, RAF1, PPP3CB, GSK3B, KRAS, PIK3CD, PAK6, PAK2, MAPK13, JUN, PIK3R3, PPP3CA, AKT2, NRAS, RELA, MAP3K7, NFKBIE, MAPK3, CBLB, MAPK1, CDC42, MAPK14, CBL, DLG1, SOS2, NFAT5, BCL10, FYN, PIK3CA",0.75448733218585,0.372634143407267,FALSE
+"H460","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.39165,-1.36,0.111,15969,0.395,"PIAS2, SMURF1, FZR1, FBXW8, TRIM37, UBE3B, UBE2B, CDC16, UBE2H, UBE2E3, NEDD4L, ELOC, RBX1, CDC34, HUWE1, UBE2E1, SOCS1, FBXO2, BIRC3, CUL5, CUL2, UBE2J1, TRIM32, PIAS1, BIRC2, CBLB, UBR5, UBE2R2, HERC3, FBXW7, UBA7, CBL, SYVN1, UBOX5, ITCH, RNF7, TRAF6, SIAH1, UBE2Q2, CUL7, MAP3K1, SMURF2, UBE2W",0.954677021213343,0.40340290437354,FALSE
+"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.73972,2.66,0,1031,0.0832,"IARS2, PDHA1, LARS2",Inf,1.07987667370928,TRUE
+"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.33712,1.25,0.178,3266,0.335,"HSD17B10, ALDH9A1, DLD, MCEE, HADH, ECHS1, ALDH3A2, ACADSB, ALDH1B1, HADHA, ACAT1, ACAA2, MCCC2, ACADS, HIBCH, IVD, OXCT1",0.749579997691106,0.474955192963155,FALSE
+"H460","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.26289,-0.903,0.555,13226,0.744,"ADCY4, PRKCH, PLA2G10, ROCK2, EDNRA, ACTG2, PRKCD, PRKCG, ADCY5, NPR2, PPP1R14A, PRKCQ, ADRA1B, GNAQ, GNA13, PLA2G12A, MYLK2, CACNA1D, PPP1CA, KCNMB4, CALML6, RAMP1, ADORA2B, MYL9, CALM3, KCNMA1, PRKCE, RAF1, ADORA2A, ITPR2, PPP1CB, KCNMB3, PRKACA, BRAF, ROCK1, MAPK3, MYL6B, MAPK1, ARHGEF12, PLA2G6, MYLK, ADCY6",0.255707016877324,0.128427064454121,FALSE
+"H460","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.30143,-1.06,0.35,16619,0.627,"CREB3L1, RAB11A, PRKACA, DYNLL2, ARHGDIB, ADCY6, RAB5A, RAB5B",0.455931955649724,0.202732459169284,FALSE
+"H460","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.34561,-1.19,0.212,16534,0.517,"SHC2, PTK2, RAF1, PPP3CB, KRAS, PIK3CD, MAPK13, PIK3R3, PPP3CA, RAC1, AKT2, NRAS, RAC2, MAPK3, MAPK1, CDC42, MAPKAPK2, VEGFA, MAPK14, PLA2G6, NFAT5, PIK3CA",0.673664139071249,0.286509456906058,FALSE
+"H460","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.2502,-0.881,0.62,11911,0.78,"TJP2, ATP6V1G1, CFTR, ATP6V0D2, TJP1, ATP6V1D, ATP6V1C2, KDELR2, KCNQ1, PRKCG, SEC61A2, ATP6V1G2, ERO1A, SEC61A1, ATP6V1B2, KDELR3, KDELR1, PLCG1, ATP6V1A, ATP6V1E1, PRKACA, ATP6V1C1, ATP6V1H, SEC61G",0.207608310501746,0.10790539730952,FALSE
+"H460","Input","KEGG_VIRAL_MYOCARDITIS",-0.19476,-0.665,0.917,11242,0.984,"ABL2, SGCG, SGCA, DAG1, SGCD, MYH11, MYH15, LAMA2, EIF4G2, MYH7B, MYH9, CCND1, ITGB2, MYH3, EIF4G3, RAC1, RAC2, ICAM1, FYN",0.0376306643299789,0.00700490156865849,FALSE
+"H460","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.36756,-1.27,0.169,16027,0.414,"PSEN1, LEF1, TCF7, FZD2, MAPK10, RBX1, CSNK1A1, APC, FZD6, PPP3CB, GSK3B, PPP2R1A, PRICKLE2, PORCN, WNT9A, JUN, VANGL2, PPP3CA, RAC1, PRKACA, EP300, MAP3K7, LRP6, ROCK1, FRAT1, RAC2, CSNK1E, PPP2R5E, WNT7B, TCF7L1, CREBBP, NLK, SMAD3, CTNNBIP1, MAPK8, SIAH1, NFAT5, CSNK2B, SENP2, DVL3, PPARD, TBL1XR1, CSNK2A1, PPP2R5B, DAAM1",0.772113295386326,0.382999658879101,FALSE
+"H1299","Input","KEGG_ABC_TRANSPORTERS",-0.27792,-1,0.436,13038,0.712,"ABCA9, ABCA10, ABCC8, ABCB11, ABCC9, ABCA8, ABCB4, ABCA6, ABCC2, ABCG1, ABCA13, ABCA4, ABCA12, ABCB10, ABCB6, ABCC6, ABCG2, ABCD3, ABCA2, ABCA5, ABCC3, ABCC1",0.360513510731414,0.147520006363144,FALSE
+"H1299","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.29126,-1.08,0.322,17481,0.614,"PPARD, IKBKB, STAT3, MAPK3, STAT5A, RARA, JUP, STAT5B, ARAF",0.492144128304169,0.211831628858832,FALSE
+"H1299","Input","KEGG_ADHERENS_JUNCTION",-0.36884,-1.33,0.15,15231,0.392,"BAIAP2, LMO7, CREBBP, ACP1, RAC1, TGFBR1, SRC, PTPRB, ERBB2, IGF1R, CTNNA1, NECTIN4, CDH1, NLK, FER, CTNND1, SORBS1, EP300, MAPK3, NECTIN1, PTPN6, SNAI2, RAC2, PTPRM",0.823908740944319,0.406713932979543,FALSE
+"H1299","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.1888,-0.687,0.895,17457,0.949,"SLC2A1, ADIPOR1, CPT1C, IKBKB, ACSL5, PPARA, STAT3, RXRA, IRS2",0.048176964684088,0.0227337875727074,FALSE
+"H1299","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.41181,-1.5,0.0798,14401,0.277,"GLS2, IL4I1, GLUD2, GLS, GFPT2, ACY3, GPT, DDO, GLUL, CPS1, ABAT, GFPT1, NIT2, ASS1",1.09799710864927,0.557520230935551,FALSE
+"H1299","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.25321,0.853,0.641,2526,1,"PIK3CG, SCNN1G, SCNN1B, ATP1A3, PIK3CB, SGK1, PRKCG",0.193141970481183,0,FALSE
+"H1299","Input","KEGG_ALLOGRAFT_REJECTION",0.22332,0.759,0.798,14847,1,"CD40, IL12A, IFNG, CD28, CD40LG, IL2, FASLG, IL12B, CD80, PRF1, FAS, IL4, IL10, CD86, GZMB, IL5, TNF",0.0979971086492706,0,FALSE
+"H1299","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.42904,-1.57,0.0421,10518,0.298,"PLA2G12B, PLA2G4B, PLA2G5, PLA2G2C, PLA2G2F, PLA2G4E, PLA2G2A, PLA2G3, PLA2G6, PLA2G10, ACOX1, FADS2, PLA2G4A, PLA2G12A",1.37571790416433,0.525783735923745,FALSE
+"H1299","Input","KEGG_ALZHEIMERS_DISEASE",-0.19494,-0.689,0.881,14669,0.965,"UQCRQ, NDUFA4, NDUFA4L2, ITPR3, TNF, CYCS, LPL, GRIN2C, CACNA1D, CAPN1, ADAM10, NDUFC2, BID, CDK5R1, NDUFV1, CACNA1C, NDUFB8, ITPR1, ATP2A3, COX6B2, BACE1, IL1B, GNAQ, NDUFS4, GSK3B, LRP1, NDUFB4, PSEN2, ATP5F1C, PLCB2, IDE, CASP8, NDUFA3, NDUFA1, UQCRC2, SNCA, BACE2, APH1A, MAPK3, ATF6, FADD, CASP7, EIF2AK3, PPP3CB",0.0550240915879521,0.0154726866562074,FALSE
+"H1299","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.41419,1.44,0.0837,2864,0.572,"VARS2, DARS2, YARS2, RARS2, PSTK, FARSA, AARS2",1.07727454200674,0.242603971206976,FALSE
+"H1299","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.37932,-1.4,0.0811,16173,0.34,"GFPT2, GMPPA, HEXA, RENBP, PGM1, GALE, NPL, NANP, HK1, MPI, GFPT1, NAGK, CYB5R1, PMM2",1.09097914578884,0.468521082957745,FALSE
+"H1299","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.24191,-0.882,0.564,17291,0.761,"RAB5A, MAPK13, CCS, MAP2K6, CASP1, CAT, PPP3CB, GPX1",0.248720896016658,0.118615343229427,FALSE
+"H1299","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.23634,0.798,0.728,1584,1,"HSP90AA1, IFNA13, HSP90AB1, HSPA1L, HSPA8, NFYC, HSPA1A, HSPA1B",0.137868620686963,0,FALSE
+"H1299","Input","KEGG_APOPTOSIS",-0.20417,-0.734,0.824,14618,0.971,"EXOG, CASP6, IL1R1, TNF, BAX, CYCS, ENDOD1, IL3RA, CAPN1, BID, IKBKG, IL1A, IL1B, CHUK, PRKACB, NGF, TNFRSF10B, CASP8, IKBKB, TNFSF10, XIAP, FADD, CASP10, CASP7, PPP3CB, MYD88",0.0840727883028842,0.0127807700919951,FALSE
+"H1299","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.46892,-1.69,0.0276,11297,0.282,"PLA2G5, CBR1, PLA2G2C, PLA2G2F, ALOX15B, CYP2C19, CYP2C9, CYP2E1, PLA2G4E, CYP2B6, PLA2G2A, CYP4A22, CYP4F2, PLA2G3, CYP2C18, PLA2G6, ALOX15, CYP2J2, GGT6, GGT5, PTGES, PTGIS, PLA2G10, TBXAS1, CYP4F3, ALOX5, GPX2, LTC4S, PTGS1, GPX7, PTGS2, GPX3, GGT1, PLA2G4A, AKR1C3, PLA2G12A, GPX1",1.55909091793478,0.549750891680639,FALSE
+"H1299","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.23539,-0.858,0.612,14340,0.796,"AOC1, GLS2, CKMT2, SAT2, CKMT1B, GLUD2, MAOB, GLS, GLUL, AGMAT, PRODH, PYCR2, ALDH18A1, CPS1, P4HA2, ALDH2, P4HA1, ASS1",0.213248577854439,0.0990869322623309,FALSE
+"H1299","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.28537,0.99,0.41,1220,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, ITGA6, CACNA2D1",0.387216143280265,0,FALSE
+"H1299","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.43031,-1.52,0.0684,9337,0.302,"UGT2B10, UGT2B11, UGT2B17, ALDH1B1, UGT2B4, UGDH, ALDH9A1, UGT2A1, UGT2A3, UGT2B15, MIOX, UGT2B7, ALDH2",1.16494389827988,0.519993057042849,FALSE
+"H1299","Input","KEGG_ASTHMA",0.2233,0.76,0.804,14847,1,"CD40, EPX, IL13, IL9, MS4A2, FCER1A, CD40LG, IL3, CCL11, IL4, IL10, PRG2, RNASE3, FCER1G, IL5, TNF",0.0947439512515487,0,FALSE
+"H1299","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.22689,0.78,0.77,1138,1,"IFNA13, CD40",0.113509274827518,0,FALSE
+"H1299","Input","KEGG_AXON_GUIDANCE",-0.40171,-1.48,0.0642,15000,0.281,"EFNB1, ABLIM2, PLXNC1, SRGAP3, CXCL12, UNC5A, SEMA4D, EPHB1, RAC1, FES, EPHA6, SLIT2, NTNG1, EPHB6, NTN4, CXCR4, GSK3B, EFNA5, NFATC2, SEMA3A, EFNA3, SEMA5A, EPHA1, EPHA4, EFNA1, PAK6, NRP1, EPHB2, EPHB3, SEMA7A, UNC5B, SEMA3F, ABLIM3, NCK2, PLXNB2, SEMA3B, L1CAM, LIMK2, MAPK3, RHOD, PLXNB1, RAC2, PLXNA2, PLXNB3, ABLIM1, PLXNA3, EFNA4, PPP3CB",1.19246497193115,0.55129368009492,FALSE
+"H1299","Input","KEGG_BASAL_CELL_CARCINOMA",0.17837,0.606,0.974,4094,1,"WNT16, FZD9, APC2, WNT5B, DVL1, PTCH2, GLI1, SMO, WNT9A, STK36, FZD7, SHH, FZD1, DVL2",0.0114410431213845,0,FALSE
+"H1299","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.34503,1.17,0.221,1899,0.91,"TBP, GTF2H4, TAF9, TAF9B, TAF6, TBPL1, TAF2, TAF5",0.655607726314889,0.0409586076789064,FALSE
+"H1299","Input","KEGG_BASE_EXCISION_REPAIR",0.29973,1.02,0.375,2724,1,"XRCC1, POLE3, POLE2, NEIL2, UNG, POLD1, POLE",0.425968732272281,0,FALSE
+"H1299","Input","KEGG_BETA_ALANINE_METABOLISM",0.18782,0.653,0.922,1279,1,"SMS, GAD1",0.0352690789463706,0,FALSE
+"H1299","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29646,1.03,0.368,3901,1,"ELOVL2, ACOT7, ACOT2, ELOVL5, ACOX3, SCD",0.434152181326482,0,FALSE
+"H1299","Input","KEGG_BLADDER_CANCER",-0.45861,-1.67,0.0495,16909,0.286,"ERBB2, DAPK2, FGFR3, EGF, CDH1, MMP2, CXCL8, MAPK3, VEGFA, VEGFB, DAPK1, ARAF",1.30539480106643,0.543633966870957,FALSE
+"H1299","Input","KEGG_BUTANOATE_METABOLISM",-0.37555,-1.39,0.0922,15843,0.342,"HMGCL, OXCT1, HADH, AKR1B10, AACS, HMGCS1, ACSM3, ABAT, ALDH2, BDH1, BDH2",1.03526907894637,0.465973893943865,FALSE
+"H1299","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.25418,-0.918,0.549,15494,0.744,"RASGRP3, IKBKG, VAV1, RAC1, BLNK, SOS2, CD81, PLCG2, CHUK, GSK3B, DAPP1, NFATC2, CARD11, SYK, IKBKB, VAV3, MAPK3, PTPN6, IFITM1, RAC2, PPP3CB",0.260427655549908,0.128427064454121,FALSE
+"H1299","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.22894,0.792,0.73,2526,1,"PTGER1, NTSR1, CACNA1A, P2RX5, CACNA1B, GRIN2D, PLCD4, ADORA2A, ADRA1B, TBXA2R, SLC8A1, TRPC1, CALM1, MYLK2, PHKA1, F2R, PLCB4, SLC25A31, NOS3, PHKG2, ADORA2B, PRKCG",0.136677139879544,0,FALSE
+"H1299","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.41512,1.45,0.0717,2224,0.606,"COX7B2, CACNG7, CACNB4, CACNG8, CACNG6, COX8C, SLC8A1, UQCRFS1, TPM2, CACNA2D1, CYC1, ATP1A3, UQCRB, COX6B1, COX4I1",1.1444808443322,0.217527375833714,FALSE
+"H1299","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.2909,-1.05,0.362,13596,0.644,"CLDN14, CD22, ITGA9, ITGB7, CADM3, SELL, VCAM1, CDH5, CDH4, CLDN16, CLDN3, CD34, CLDN2, ITGB2, ESAM, ITGAV, NLGN4X, CD6, SDC3, CNTNAP2, NRXN2, CLDN9, CD8A, MPZ, CD276, F11R, NRXN3, CLDN11, VCAN, PDCD1LG2, SELPLG, NCAM1, MPZL1, CD58, NRCAM, CDH3, ICAM2, CLDN23, CLDN4, CD99, SDC2, CDH1, CLDN7, SDC1, CADM1, L1CAM, ITGB8, NECTIN1, ALCAM, PTPRM",0.441291429466834,0.191114132640188,FALSE
+"H1299","Input","KEGG_CELL_CYCLE",0.47877,1.62,0.0444,4683,0.394,"CCNA1, E2F5, PRKDC, MCM7, BUB1, ANAPC4, DBF4, ESPL1, CDC20, CDKN2D, CCNB1, TTK, ANAPC13, MCM4, CDK7, PLK1, ORC3, RAD21, YWHAQ, MAD2L2, PTTG1, CCNB2, TGFB1, CDKN2A, CDC14A, E2F2, YWHAZ, MCM2, CDKN2B, E2F3, CDC25C, CDC25A, CDK6, ANAPC1, CCNA2, HDAC2, CHEK1, SMC1A, SMC1B, ATR, FZR1, MCM6, HDAC1, CDKN2C, ANAPC7, MCM5, ANAPC5, E2F4, GADD45B, CCNE2, TGFB3, ORC1, CCNH, CDC45, YWHAB, CUL1, E2F1, CDC7, PTTG2, CHEK2, MAD1L1, ZBTB17, ORC2",1.35261702988538,0.404503778174426,FALSE
+"H1299","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.19879,-0.718,0.855,15596,0.989,"ADCY4, CXCL5, ADCY9, IKBKG, VAV1, RAC1, PRKCD, CXCL16, ADCY5, GRK7, CCL26, SHC3, CCL5, CXCR4, SOS2, CCL20, CHUK, GSK3B, PRKACB, ADCY6, CX3CL1, GRK2, CCL2, ADCY1, GNG2, ARRB1, PLCB2, STAT2, STAT1, IKBKB, VAV3, ADCY7, FOXO3, STAT3, RAP1A, CXCL8, MAPK3, RAC2, PTK2B, STAT5B",0.0680338852718274,0.0048037084028206,FALSE
+"H1299","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.25172,0.874,0.607,3777,1,"PIK3CG, MECOM, TGFB1, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, HDAC2, CRK, CTBP1, PTPN11, CBL, AKT2, HDAC1, PIK3CD, NRAS, NFKB1, SHC1, RUNX1",0.216811308924742,0,FALSE
+"H1299","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.37612,-1.35,0.113,16225,0.373,"CLOCK, BHLHE40, PER2, NR1D1, CRY2",0.94692155651658,0.428291168191312,FALSE
+"H1299","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.38307,-1.4,0.0929,17118,0.34,"IDH3G, SUCLA2, FH, ACLY, MDH1, IDH1, PC, IDH2",1.03198428600636,0.468521082957745,FALSE
+"H1299","Input","KEGG_COLORECTAL_CANCER",0.25852,0.879,0.601,5438,1,"PIK3CG, FOS, TGFB1, APC2, AKT1, APPL1, PIK3CB, AKT2, RAC3, PIK3CD, MSH3, BIRC5, MSH6, TGFB3, BAD, MLH1, RHOA, MSH2, MAPK9, PIK3R3, RAF1, MYC, JUN, MAPK10, SMAD4, CASP9",0.22112552799726,0,FALSE
+"H1299","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.36445,-1.31,0.128,11642,0.4,"C5, F7, MASP1, FGA, F13A1, C6, PROS1, C4BPA, CR2, SERPIND1, FGG, FGB, F5, C5AR1, SERPING1, PLG, F8, A2M, C3AR1, VWF, SERPINA5, KLKB1, C4BPB, SERPINF2, TFPI, BDKRB1, PROC, CFI, PLAT, THBD, C2, BDKRB2, CD55, CFH, C3, C1S, CFB, F3, C1R, CD46",0.892790030352132,0.397940008672038,FALSE
+"H1299","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.29925,1.03,0.388,5315,1,"CDO1, SMS, DNMT1, AHCY, CBS, LDHB, SRM, MTAP, ADI1, DNMT3A, APIP, TRDMT1, AMD1, AHCYL2",0.411168274405793,0,FALSE
+"H1299","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.25288,-0.918,0.537,11532,0.744,"OSM, CX3CR1, IL10, IFNW1, CXCL9, CCL24, IL19, PF4, PDGFB, PPBP, IL12RB2, CCR9, IFNA21, CCL3L3, IL18RAP, IL1RAP, CCL25, TNFSF9, TNFSF4, IFNL2, LIF, IFNA8, IFNL3, IL10RB, CCL15, LIFR, IL2RA, CLCF1, IL23A, CCL3, TPO, IL2RB, LEPR, IL17B, IL13RA1, TNFRSF4, CCL22, EGFR, IFNA1, CCR3, IFNA5, CSF3, IFNL1, MET, KIT, IFNB1, CCR1, PRLR, KDR, EDAR, RELT, CXCL11, CCL17, TNFSF18, HGF, CXCL1, CCR7, CRLF2, FLT1, TNFSF14, CXCL3, CNTFR, IL20RA, IL12RB1, TSLP, IL5, TNFSF13B, IFNGR1, CXCL6, CXCL14, IL1R1, TNF, CXCL10, BMPR1A, IL21R, ACVRL1, IL3RA, IL2RG, IL24, IL17RB, IL7R, CXCL12, TNFSF15, PDGFRA, CD27, IL20RB, CXCL5, TNFRSF18, CSF2, CSF2RA, CSF1R, CXCL16, EDA2R, CCL26, IL1A, CCL5, IL1B, CXCR4, NGFR, IL22RA1, IL11, CCL20, TGFBR1, PDGFRB, IL1R2, TNFRSF11B, INHBE, TNFRSF10B, INHBB, CX3CL1, BMP2, IL15, CCL2, IFNLR1, IL6, EGF, INHBA, TNFRSF19, IL15RA, TNFSF10, TNFRSF21, TNFSF13, IL6R, CSF1, CXCL8, TNFSF12, IL18, VEGFA, TNFRSF14, KITLG, FLT3LG, VEGFB, PDGFA, LTBR",0.270025714300444,0.128427064454121,FALSE
+"H1299","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.30995,-1.13,0.266,15724,0.578,"IKBKG, AIM2, POLR3B, CCL5, IL1B, CHUK, IL6, IKBKB, PYCARD, POLR1D, CASP1, MAVS, IKBKE, IL18, TREX1",0.575118363368933,0.238072161579471,FALSE
+"H1299","Input","KEGG_DILATED_CARDIOMYOPATHY",0.25915,0.878,0.583,1574,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, TPM2, ITGA6, CACNA2D1, TGFB1",0.234331445240986,0,FALSE
+"H1299","Input","KEGG_DNA_REPLICATION",0.59819,2.04,0.0112,3534,0.162,"MCM7, RFC1, MCM4, POLA1, PRIM1, RPA2, POLE3, POLE2, MCM2, POLD1, POLE, RFC2, RNASEH2A, RNASEH1, PRIM2, RPA1, MCM6, RFC5, MCM5",1.95078197732982,0.790484985457369,TRUE
+"H1299","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.2771,-1,0.392,16413,0.712,"SOS2, FMN2, NOTCH1, ETV7, ETS2, MAPK3",0.406713932979543,0.147520006363144,FALSE
+"H1299","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.41269,-1.53,0.056,9885,0.317,"UGT2B11, UGT2B17, GSTA3, CYP2A13, FMO2, UGT2B4, ADH7, ADH4, CYP1A2, FMO1, UGT2A1, UGT2A3, GSTM5, CYP2C19, UGT2B15, GSTP1, GSTA2, CYP2A7, GSTM3, FMO3, CYP2C9, CYP2E1, CYP2B6, CYP3A4, GSTA1, MAOA, ADH1C, GSTM4, CYP2C18, CYP2A6, GSTO1, CYP3A7, UGT2B7, GSTM1, MAOB, ALDH3B2, FMO5, MGST3, CYP3A5, MGST1, GSTZ1, ALDH1A3, CYP2D6, ALDH3A1, GSTO2, GSTT2, FMO4, MGST2",1.2518119729938,0.498940737782249,FALSE
+"H1299","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.17863,-0.653,0.941,11225,0.96,"UGT2A1, CES5A, UPB1, UGT2A3, UGT2B15, CYP2A7, TYMP, DPYS, CYP3A4, CYP2A6, NAT2, TK2, CES1, CYP3A7, UPP1, UGT2B7, CES2, CYP3A5, CDA, NAT1",0.0264103765727431,0.0177287669604316,FALSE
+"H1299","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.38238,-1.37,0.115,14594,0.357,"VTN, THBS2, ITGAV, VWF, CD36, COL5A3, SDC3, ITGA11, HSPG2, COL6A3, THBS1, ITGA1, COL1A2, COL3A1, COL4A4, CHAD, LAMA4, FN1, COL4A6, LAMA1, LAMC1, ITGB6, GP1BB, ITGB4, AGRN, TNC, COL5A2, SDC2, LAMB1, COL5A1, SV2A, LAMA3, SDC1, ITGB8, COL1A1, COL4A1, COL4A2",0.939302159646388,0.447331783887807,FALSE
+"H1299","Input","KEGG_ENDOCYTOSIS",-0.22064,-0.805,0.744,15437,0.884,"VPS37C, PDGFRA, MDM2, ERBB3, AGAP2, PIP4K2B, PSD, CSF1R, NEDD4L, TFRC, RAB22A, GRK7, ARAP2, STAM, CXCR4, ARF6, SRC, EPS15, CHMP6, STAMBP, DNM1, GRK2, EPN3, CBLC, RAB5A, CHMP4B, IGF1R, LDLRAP1, ARRB1, ARFGAP2, FGFR3, CHMP2B, RAB11FIP1, ARAP1, EGF, RAB5B, FGFR2, RAB11FIP4, PARD6B, PARD6G, ACAP3, CBLB, TSG101, RAB5C, VPS25, PSD4, TRAF6",0.128427064454121,0.0535477349869269,FALSE
+"H1299","Input","KEGG_ENDOMETRIAL_CANCER",-0.24859,-0.918,0.538,16413,0.744,"SOS2, GSK3B, ERBB2, PDPK1, CTNNA1, EGF, CDH1, FOXO3, MAPK3, ARAF",0.269217724333611,0.128427064454121,FALSE
+"H1299","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.23971,-0.886,0.609,15427,0.77,"ADAM10, ATP6V0A1, IKBKG, ATP6V1E1, RAC1, ATP6V1A, ATP6V0A4, ATP6V1B2, CCL5, ATP6V1G2, F11R, PLCG2, CHUK, SRC, MAPK13, IKBKB, ATP6V1B1, ATP6AP1, ATP6V0E1, CXCL8",0.215382707367125,0.113509274827518,FALSE
+"H1299","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.26719,-0.955,0.475,15648,0.719,"RPS6KB2, ERBB3, CAMK2B, SHC3, SOS2, NRG4, PLCG2, SRC, GSK3B, ERBB2, EREG, CBLC, BTC, PAK6, EGF, AREG, NCK2, GAB1, MAPK3, CBLB, STAT5A, STAT5B, ARAF",0.323306390375133,0.143271109617117,FALSE
+"H1299","Input","KEGG_ETHER_LIPID_METABOLISM",-0.192,-0.693,0.903,16979,0.968,"LPCAT2, PLPP3, PLA2G4A, PLA2G12A",0.0443122496864942,0.0141246426916063,FALSE
+"H1299","Input","KEGG_FATTY_ACID_METABOLISM",-0.21241,-0.775,0.775,13073,0.941,"ACSL6, CYP4A22, ADH1C, ACSL4, ECHS1, CPT2, CPT1B, EHHADH, ACSL1, ACOX1, ACAA1, HADHB, HADH, CPT1C, ACSL5, ALDH2",0.11069829749369,0.0264103765727431,FALSE
+"H1299","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.18973,-0.688,0.936,13586,0.957,"PLA2G3, FCER1G, PLA2G6, GAB2, PRKCA, MAPK8, INPP5D, IL5, TNF, PLA2G10, CSF2, VAV1, RAC1, PRKCD, SOS2, PLCG2, PDPK1, SYK, MAPK13, VAV3, MAP2K6, PLA2G4A, MAPK3, RAC2, PLA2G12A",0.0287241512618947,0.0190880622231565,FALSE
+"H1299","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.18159,0.618,0.972,4882,1,"PIK3CG, VASP, ARPC1A, DNM1L, PIKFYVE, ASAP1, AKT1, ARPC1B, PIK3CB, PLPP2, CRK, PRKCG, WASF1, AKT2, PLD2, MYO10, PIK3CD, CFL2, ASAP3, WASF2, PRKCE, ASAP2, GSN, ARPC5L, LIMK1, FCGR3A, WASF3, PIK3R3",0.0123337350737254,0,FALSE
+"H1299","Input","KEGG_FOCAL_ADHESION",-0.20704,-0.759,0.803,15701,0.964,"COL6A3, VAV1, RAC1, THBS1, ITGA1, COL1A2, COL3A1, COL4A4, SHC3, SOS2, CHAD, SRC, GSK3B, PDGFRB, LAMA4, FN1, ERBB2, RASGRF1, COL4A6, LAMA1, LAMC1, PDPK1, ITGB6, ITGB4, IGF1R, PAK6, EGF, TNC, COL5A2, VAV3, LAMB1, COL5A1, LAMA3, XIAP, RAP1A, ITGB8, MAPK3, COL1A1, VEGFA, ARHGAP5, RAC2, VEGFB, COL4A1, COL4A2, PDGFA, PPP1CB",0.095284454721319,0.0159229660971692,FALSE
+"H1299","Input","KEGG_FOLATE_BIOSYNTHESIS",0.24073,0.83,0.688,4660,1,"GGH, SPR, DHFR, PTS",0.162411561764489,0,FALSE
+"H1299","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.55088,-1.96,0.0118,15333,0.279,"FPGT, ALDOA, FBP1, PFKFB3, GMPPA, AKR1B10, PFKFB4, PFKFB2, MTMR6, HK1, MPI, ALDOC, PMM2",1.92811799269387,0.554395796726402,FALSE
+"H1299","Input","KEGG_GALACTOSE_METABOLISM",-0.3003,-1.07,0.355,16980,0.624,"PGM1, GALE, GLB1, HK1, B4GALT1",0.449771646944906,0.204815410317576,FALSE
+"H1299","Input","KEGG_GAP_JUNCTION",-0.26765,-0.983,0.417,14284,0.718,"PRKCA, GUCY1A1, DRD2, TUBAL3, ITPR3, HTR2C, PDGFRA, ADCY4, ADCY9, TUBA8, ITPR1, ADCY5, LPAR1, TUBA3D, GNAQ, SOS2, SRC, PDGFRB, PRKACB, ADCY6, ADCY1, PLCB2, EGF, ADCY7, GJA1, MAPK3, PDGFA, TUBA4A",0.379863945026242,0.1438755557577,FALSE
+"H1299","Input","KEGG_GLIOMA",0.22609,0.768,0.756,3610,1,"PIK3CG, CALM1, MTOR, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, PRKCG, AKT2, PIK3CD, NRAS, SHC1",0.121478204498793,0,FALSE
+"H1299","Input","KEGG_GLUTATHIONE_METABOLISM",-0.41264,-1.5,0.0625,16112,0.277,"GGCT, GPX2, GSR, MGST3, MGST1, GSTZ1, GCLC, GPX7, GSTO2, GSTT2, GPX3, GGT1, IDH1, G6PD, IDH2, MGST2, GPX1",1.20411998265592,0.557520230935551,FALSE
+"H1299","Input","KEGG_GLYCEROLIPID_METABOLISM",0.21209,0.722,0.849,2239,1,"GPAT2, AGPAT1, GPAT3, DGAT2, DGKE, PLPP2",0.0710923097560473,0,FALSE
+"H1299","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.23145,0.782,0.768,2728,1,"GPAT2, PEMT, AGPAT1, LYPLA1, GPAT3, CHPT1, ACHE, DGKE, PLPP2, ETNK1, PTDSS1, LPCAT3",0.114638779968488,0,FALSE
+"H1299","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.21311,0.738,0.834,804,1,"GLDC, ALAS1",0.0788339493622613,0,FALSE
+"H1299","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.2349,-0.889,0.596,15309,0.791,"PCK2, ALDH3B2, ALDOA, FBP1, ALDH1A3, LDHA, PGM1, ALDH3A1, HK1, ALDH2, ACSS1, ALDOC, AKR1A1",0.224753740259764,0.101823516502323,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.18115,-0.674,0.94,14570,0.956,"B3GAT1, B3GAT3, CHPF, B4GALT7, XYLT1, CHST15",0.0268721464003014,0.0195421077238999,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35545,-1.28,0.164,13971,0.393,"EXTL1, B3GAT1, B3GAT3, B4GALT7, EXT1, GLCE, XYLT1, HS6ST1, HS3ST1, HS6ST2, EXT2",0.785156151952302,0.405607449624573,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.57759,-2.15,0.00831,15489,0.439,"CHST1, CHST6, ST3GAL3, B3GNT7, B3GNT2, ST3GAL1, B4GALT4, B4GALT1",2.08039897621589,0.357535479757879,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.41674,-1.51,0.0638,16808,0.3,"HEXA, GLB1, IDUA, IDS, HGSNAT, NAGLU",1.19517932127884,0.522878745280338,FALSE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.33653,1.15,0.235,4284,0.842,"ST6GALNAC4, ST6GALNAC6, ST8SIA5, B4GALNT1, ST3GAL2, ST6GALNAC3, ST8SIA1",0.628932137728264,0.0746879085003505,FALSE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.52051,-1.91,0.0134,16808,0.235,"HEXA, GBGT1, FUT2, ST3GAL1, FUT1, B3GALNT1",1.87289520163519,0.628932137728264,TRUE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.40077,-1.5,0.0572,15219,0.277,"B3GALT5, ST3GAL4, ABO, ST3GAL3, FUT3, B3GNT3, B3GNT2, FUT2, B4GALT4, FUT1, B4GALT1",1.24260397120698,0.557520230935551,FALSE
+"H1299","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.27392,-0.98,0.42,14781,0.714,"PIGY, PIGK, PIGM, PIGQ, PIGC, PIGB, PIGV, PIGS",0.3767507096021,0.146301788223826,FALSE
+"H1299","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.4312,1.46,0.097,3418,0.649,"MDH2, MTHFD1L, MTHFD2L, MTHFD1, CS, GRHPR",1.01322826573376,0.187755303199631,FALSE
+"H1299","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.24188,-0.888,0.586,14832,0.784,"ITPR3, PLA2G10, ATF4, CACNA1D, ADCY4, CACNA1C, ADCY9, ITPR1, PRKCD, CAMK2B, ADCY5, GNAQ, SOS2, SRC, PRKACB, ADCY6, ADCY1, MAPK13, PLCB2, MMP2, ADCY7, MAP2K6, PLA2G4A, MAPK3, PLA2G12A, MAP3K1, PTK2B",0.232102383981909,0.105683937315562,FALSE
+"H1299","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.45297,-1.65,0.0582,8677,0.272,"IFNG, CD28, KIR2DL1, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, FAS, KLRC1, CD86, GZMB, TNF, IL1A, IL1B, IL6",1.23507701535011,0.565431095965801,FALSE
+"H1299","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.20398,-0.75,0.821,16658,0.961,"GSK3B, PRKACB, WNT11, GAS1, BMP2, SUFU, GLI2, BMP4, WNT5A, BTRC, WNT7B",0.0856568428805592,0.0172766123314547,FALSE
+"H1299","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.24664,-0.922,0.553,13245,0.764,"CD3D, THPO, CD7, CSF3, KIT, CD22, CD33, CD34, IL5, CD1D, IL1R1, TNF, IL3RA, CD36, IL7R, FCGR1A, CSF2, CD14, CSF2RA, CSF1R, TFRC, ITGA1, CD8A, IL1A, IL1B, IL11, IL1R2, GP1BB, IL6, CD55, IL6R, CSF1, KITLG, FLT3LG",0.257274868695302,0.11690664142431,FALSE
+"H1299","Input","KEGG_HISTIDINE_METABOLISM",0.27812,0.949,0.491,397,1,"FTCD, BUD23",0.308918507877032,0,FALSE
+"H1299","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.6082,2.07,0.00159,3832,0.209,"XRCC3, EME1, RAD54L, RAD51C, RAD54B, RAD52, RPA2, TOP3A, RAD51B, SEM1, POLD1, RAD51, RPA1, NBN, XRCC2",2.79860287567955,0.679853713888946,TRUE
+"H1299","Input","KEGG_HUNTINGTONS_DISEASE",0.27481,0.932,0.505,3801,1,"COX7B2, DNAI1, TBP, POLR2D, COX8C, NDUFB9, UQCRFS1, IFT57, TBPL1, POLR2I, POLR2A, NDUFA9, CYC1, PLCB4, TGM2, SLC25A31, SDHB, DLG4, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, HIP1, HDAC2, ATP5F1B, CLTA, RCOR1, TFAM, DNAL1, POLR2K, COX8A, NDUFS6, NDUFV2, SLC25A6, COX6C, HDAC1, HTT, POLR2J, TAF4B, NDUFB1, POLR2E, CLTC",0.296708621881339,0,FALSE
+"H1299","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.30585,1.04,0.336,1574,1,"CACNG7, CACNB4, CACNG8, CACNG6, ITGA4, ITGA10, SLC8A1, TPM2, PRKAG2, ITGA6, CACNA2D1, TGFB1",0.473660722610156,0,FALSE
+"H1299","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.26101,0.889,0.574,2189,1,"PIK3CG, ISYNA1, IMPA1, PLCD4, INPP5E, PIKFYVE, PLCB4, PIK3CB",0.241088107602027,0,FALSE
+"H1299","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.1952,-0.714,0.877,16279,0.986,"SHC3, EIF4E2, PRKAB2, SOS2, GSK3B, PRKACB, PHKB, GYS1, MKNK1, PPP1R3B, PDPK1, PPP1R3D, CBLC, IKBKB, SOCS4, PHKG1, FLOT2, SORBS1, HK1, MAPK3, FOXO1, CBLB, PPP1CB, IRS2, ARAF",0.0570004066339595,0.0061230850587888,FALSE
+"H1299","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.29015,0.985,0.447,1574,0.972,"MAP3K14, ITGA4, MADCAM1, CD40, TGFB1",0.349692476868064,0.0123337350737254,FALSE
+"H1299","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.19629,-0.71,0.901,14369,0.982,"CNTFR, IL20RA, IL12RB1, TSLP, IL5, SPRY3, IFNGR1, IL21R, IL3RA, IL2RG, IL24, SOCS1, IL7R, PIAS1, IL20RB, CREBBP, CSF2, CSF2RA, STAT6, STAM, SOS2, IL22RA1, IL11, SOCS5, CISH, IL15, CBLC, STAT4, IFNLR1, IL6, STAT2, STAT1, IL15RA, SOCS4, STAT3, EP300, IL6R, PTPN6, IRF9, CBLB, STAT5A, STAT5B",0.045275209020937,0.00788851221305034,FALSE
+"H1299","Input","KEGG_LEISHMANIA_INFECTION",-0.24432,-0.875,0.601,15945,0.767,"FCGR2A, IL1A, IL1B, TAB1, TLR2, TLR4, NCF2, PTGS2, MAPK13, STAT1, C3, MAPK3, PTPN6, TRAF6, MYD88",0.22112552799726,0.115204636051019,FALSE
+"H1299","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19773,0.673,0.903,4294,1,"PIK3CG, ITGAM, ITGA4, VASP, CLDN20, PXN, JAM3, BCAR1, MAPK11, MAPK12, PIK3CB, PTK2, CYBB, PRKCG, CLDN15, EZR, PTPN11, SIPA1, ICAM1, MYL9, PIK3CD, ACTG1, VCL, MYL12A, GNAI2, OCLN, MYL12B, MMP9, AFDN, CYBA",0.0443122496864942,0,FALSE
+"H1299","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.47181,-1.71,0.0361,14291,0.336,"ECHS1, EHHADH, YOD1, ALDH2",1.44249279809434,0.473660722610156,FALSE
+"H1299","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.49029,-1.76,0.0231,10518,0.396,"PLA2G12B, CYP1A2, PLA2G4B, PLA2G5, PLA2G2C, PLA2G2F, CYP2C19, CYP2C9, CYP2E1, PLA2G4E, CYP3A4, PLA2G2A, PLA2G3, CYP2C18, PLA2G6, ALOX15, CYP2J2, PLA2G10, CYP3A7, CYP3A5, AKR1B10, PLA2G4A, PLA2G12A",1.63638802010786,0.402304814074488,FALSE
+"H1299","Input","KEGG_LONG_TERM_DEPRESSION",-0.17187,-0.621,0.97,11611,0.968,"PLA2G2F, GNA12, PPP2CB, GNAI3, PRKG2, GNA13, PRKCB, NOS1, PLA2G4E, GRID2, PLA2G2A, CRHR1, IGF1, PLA2G3, GRIA3, PLCB1, PLA2G6, PRKCA, GUCY1A1, PPP2R1A, ITPR3, PLA2G10, ITPR1, GNAO1, GNAQ, RYR1, IGF1R, PLCB2, PLA2G4A, MAPK3, PLA2G12A, ARAF",0.0132282657337552,0.0141246426916063,FALSE
+"H1299","Input","KEGG_LONG_TERM_POTENTIATION",-0.29678,-1.08,0.297,14832,0.614,"ITPR3, ATF4, GRIN2C, CREBBP, CACNA1C, ITPR1, RPS6KA1, CAMK2B, GNAQ, PRKACB, ADCY1, PLCB2, EP300, RAP1A, MAPK3, RPS6KA2, PPP1CB, PPP3CB, ARAF",0.527243550682788,0.211831628858832,FALSE
+"H1299","Input","KEGG_LYSINE_DEGRADATION",0.20615,0.702,0.863,3083,1,"EHMT2, NSD2, KMT5A, SETD1A, DLST, ACAT2, EHMT1, DOT1L",0.0639892042847904,0,FALSE
+"H1299","Input","KEGG_LYSOSOME",-0.35284,-1.3,0.146,14720,0.393,"AP3S2, SLC11A2, NPC2, GNS, TPP1, PPT1, HYAL1, ATP6V0A1, GM2A, CD63, SMPD1, ATP6V0A4, GBA, GGA2, ACP5, GNPTAB, HEXA, CTSO, CTSH, ACP2, CTSB, ABCA2, GLB1, AGA, IDUA, CLN5, ARSA, ATP6AP1, FUCA1, GNPTG, SCARB2, LIPA, CTSS, LAMP1, IDS, CTSD, ASAH1, LAPTM4A, LAMP2, PSAP, HGSNAT, NAGLU, SUMF1",0.835647144215563,0.405607449624573,FALSE
+"H1299","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.20847,0.715,0.87,3714,1,"CACNA1A, CACNG7, CACNB4, MAP3K14, CACNG8, CACNG6, CACNA1B, RELB, FLNC, NFKB2, NR4A1, DAXX, FOS, MEF2C, HSPA1L, HSPA8, FGF5, MAP3K12, CACNA2D1, SRF, STK4, MAP2K3, MAPK8IP2, FGF12, PAK2, HSPA1A, MECOM, TGFB1, MAP3K7, HSPA1B, MAPK11, RASGRP2, AKT1, MAP3K5, MAP2K2, DUSP1, MAPK12, FGF11, CRK, MAPKAPK3, PRKCG, TNFRSF1A, AKT2, RAC3, TRAF2, ECSIT, RRAS, HSPB1, JUND, MAPK7, MAP3K3, FGF1, PPP3R2, NRAS, NFKB1, MAP4K4, RPS6KA4, MAPK8IP1, ARRB2",0.0604807473813815,0,FALSE
+"H1299","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.22963,0.784,0.75,208,1,"GCK",0.1249387366083,0,FALSE
+"H1299","Input","KEGG_MELANOGENESIS",-0.22376,-0.821,0.722,15411,0.858,"WNT4, WNT7A, ADCY4, CREBBP, ADCY9, GNAO1, CAMK2B, ADCY5, DVL3, GNAQ, GSK3B, PRKACB, WNT11, ADCY6, ADCY1, PLCB2, CREB3L2, MITF, ADCY7, WNT5A, EP300, EDN1, MAPK3, WNT7B, KITLG",0.141462802430361,0.0665127121512946,FALSE
+"H1299","Input","KEGG_MELANOMA",0.19777,0.669,0.918,3514,1,"PIK3CG, FGF5, FGF12, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, FGF11, AKT2, PIK3CD, FGF1, NRAS",0.0371573187987575,0,FALSE
+"H1299","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.44672,-1.63,0.0492,11789,0.277,"AKR1C4, CYP2C19, UGT2B15, GSTP1, GSTA2, GSTM3, CYP2C9, CYP2E1, CYP1B1, CYP2B6, CYP2F1, CYP3A4, GSTA1, ADH1C, GSTM4, CYP2C18, GSTO1, AKR1C2, CYP3A7, UGT2B7, GSTM1, CYP1A1, ALDH3B2, MGST3, CYP3A5, MGST1, GSTZ1, ALDH1A3, ALDH3A1, AKR1C1, GSTO2, GSTT2, DHDH, EPHX1, CYP2S1, AKR1C3, MGST2",1.30803489723264,0.557520230935551,FALSE
+"H1299","Input","KEGG_MISMATCH_REPAIR",0.51204,1.75,0.017,4775,0.462,"RFC1, RPA2, POLD1, RFC2, RPA1, RFC5, MSH3, MSH6, MLH1, POLD2, RFC4, MSH2",1.76955107862173,0.335358024443874,FALSE
+"H1299","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.24636,-0.887,0.591,17065,0.777,"PDPK1, MLST8, HIF1A, MAPK3, VEGFA, DDIT4, VEGFB, RPS6KA2",0.228412519118745,0.109578981199086,FALSE
+"H1299","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.17933,-0.653,0.945,14477,0.96,"KLRK1, SHC2, LCK, IFNGR1, ITGB2, TNF, KLRC2, RAET1G, BID, CSF2, VAV1, RAC1, SHC3, RAET1L, ULBP2, SOS2, SH3BP2, PLCG2, NFATC2, TNFRSF10B, ICAM2, SYK, VAV3, TNFSF10, MAPK3, PTPN6, RAC2, PTK2B, PPP3CB, ARAF",0.0245681914907371,0.0177287669604316,FALSE
+"H1299","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.27024,0.925,0.522,949,1,"PTGER1, GABRA4, NTSR1, MC5R, S1PR1, NPFFR2, P2RX5, NMUR1, CHRNB1, GABRD, F2RL1, GRIN2D, ADORA2A, GABRB3, ADRA1B, TBXA2R, P2RY1, ADRA2C, MC1R",0.282329496997738,0,FALSE
+"H1299","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.2068,0.714,0.861,3664,1,"PIK3CG, NFKBIB, CALM1, YWHAQ, ZNF274, SH2B3, IRAK2, MAPK11, AKT1, MAP3K5, MAP2K2, YWHAZ, PRDM4, MAPK12, NFKBIE, PSEN1, PIK3CB, CRK, RAPGEF1, PTPN11, AKT2, IRAK1, PIK3CD, TP73, MAPK7, MAP3K3, NRAS, NFKB1, SHC1, RPS6KA4",0.0649968485463452,0,FALSE
+"H1299","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.48124,-1.72,0.0297,16535,0.404,"NT5C1B, NMNAT2, NAMPT, NT5C3A, NNMT, NMRK1, NADSYN1, QPRT, NUDT12, NNT",1.52724355068279,0.393618634889395,FALSE
+"H1299","Input","KEGG_NITROGEN_METABOLISM",-0.44836,-1.65,0.0301,14401,0.272,"GLS2, HAL, GLUD2, CA14, GLS, CA8, CTH, GLUL, CA9, AMT, CPS1, CA12",1.52143350440616,0.565431095965801,FALSE
+"H1299","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.27656,0.97,0.465,809,0.989,"HSP90AA1, CXCL2, CARD18, CARD8, NFKBIB, NLRP1, HSP90AB1, BIRC3",0.332547047110046,0.0048037084028206,FALSE
+"H1299","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.2977,1.02,0.38,3035,1,"PRKDC, XRCC4, XRCC5",0.42021640338319,0,FALSE
+"H1299","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.23522,0.814,0.714,3514,1,"PIK3CG, STK4, CDKN2A, E2F2, AKT1, MAP2K2, PIK3CB, E2F3, CDK6, PRKCG, AKT2, PIK3CD, NRAS",0.146301788223826,0,FALSE
+"H1299","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.26416,-0.969,0.401,16297,0.717,"CTBP2, DVL3, DTX1, MFNG, NOTCH1, MAML2, PSEN2, LFNG, DTX4, EP300, APH1A, CIR1, DTX3L",0.396855627379818,0.1444808443322,FALSE
+"H1299","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.40729,1.38,0.11,3479,0.568,"ERCC1, RFC1, GTF2H4, CDK7, GTF2H5, RPA2, POLE3, ERCC3, POLE2, RAD23A, ERCC2, POLD1, POLE, RFC2, RPA1, RFC5",0.958607314841775,0.245651664288981,FALSE
+"H1299","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.2575,-0.939,0.476,14460,0.736,"ST6GAL1, MGAT3, MOGS, MAN2A1, MGAT5, MGAT1, ALG9, ALG5, STT3A, ALG2, MGAT4A, MAN1C1, ALG11, MAN1A2, B4GALT1",0.322393047279507,0.133122185662501,FALSE
+"H1299","Input","KEGG_OLFACTORY_TRANSDUCTION",0.20492,0.717,0.869,1072,1,"OR3A2, OR8G1, OR3A1, OR8D2, OR52H1, OR2J2, OR8G5, OR8A1, OR1F1, OR2W3, CALM1",0.0609802235513335,0,FALSE
+"H1299","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.50595,1.74,0.0159,4076,0.386,"FTCD, MTHFD1L, TYMS, MTHFD2L, MTHFD1, GART, DHFR, ATIC",1.79860287567955,0.413412695328245,FALSE
+"H1299","Input","KEGG_OOCYTE_MEIOSIS",0.33974,1.16,0.243,4362,0.894,"STAG3, FBXO43, BUB1, ANAPC4, ESPL1, CDC20, CCNB1, AURKA, CPEB1, ANAPC13, CALM1, PLK1, YWHAQ, MAD2L2, PTTG1, CCNB2, PPP2R5D, PPP2R5C, YWHAZ, MAPK12, CDC25C, ANAPC1, FBXO5, PPP1CC, SMC1A, SMC1B, SGO1, ITPR2, ANAPC7, PPP3R2, ANAPC5, CALM3, CCNE2, PRKX, PPP2R5E, YWHAB, CUL1, PTTG2",0.614393726401688,0.0486624812040823,FALSE
+"H1299","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.46715,-1.69,0.0256,15905,0.282,"MAN2C1, GBA, HEXA, ENGASE, GLB1, AGA, FUCA1",1.59176003468815,0.549750891680639,FALSE
+"H1299","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22936,0.775,0.764,3724,1,"COX7B2, COX8C, NDUFB9, UQCRFS1, ATP5ME, ATP6V1C1, NDUFA9, CYC1, SDHB, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, ATP6V1D, ATP5F1B, ATP6V0E2, NDUFA11, ATP6V1H, COX8A, NDUFS6, NDUFV2, COX6C, NDUFB1, COX10",0.11690664142431,0,FALSE
+"H1299","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.4609,-1.71,0.038,15740,0.336,"ST6GALNAC1, GCNT4, GALNT6, GALNT9, GALNT2, GCNT3, GALNT5, GCNT1, GALNT1, ST3GAL1, GALNT7, GALNT3, GALNT12, B4GALT5",1.42021640338319,0.473660722610156,FALSE
+"H1299","Input","KEGG_P53_SIGNALING_PATHWAY",-0.20368,-0.756,0.836,14685,0.959,"PTEN, SESN3, BAX, TSC2, CYCS, MDM2, BID, CCNE1, DDB2, THBS1, TNFRSF10B, SERPINB5, GADD45G, ZMAT3, CASP8, MDM4, SIAH1, CCNG2, SFN, IGFBP3, COP1",0.0777937225609836,0.0181813928293364,FALSE
+"H1299","Input","KEGG_PANCREATIC_CANCER",-0.25745,-0.966,0.437,15724,0.713,"IKBKG, RAC1, ARHGEF6, TGFBR1, CHUK, ERBB2, EGF, STAT1, IKBKB, STAT3, MAPK3, VEGFA, RAC2, VEGFB, RALA, ARAF",0.359518563029578,0.146910470148134,FALSE
+"H1299","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41051,-1.48,0.0784,17871,0.281,"PANK2, PANK1, PPCS",1.10568393731556,0.55129368009492,FALSE
+"H1299","Input","KEGG_PARKINSONS_DISEASE",0.29047,0.987,0.443,3628,0.996,"COX7B2, COX8C, LRRK2, NDUFB9, UQCRFS1, NDUFA9, CYC1, UCHL1, SLC25A31, SDHB, HTRA2, UQCRB, COX6B1, COX4I1, NDUFA7, ATP5MC1, ATP5F1B, UBE2G1, GPR37, COX8A, UBE2J2, NDUFS6, NDUFV2, SLC25A6, COX6C, PARK7, NDUFB1, UBB",0.35359627377693,0.00174066157630127,FALSE
+"H1299","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.20995,0.718,0.848,4841,1,"ARPC1A, TUBB3, YWHAQ, NCL, YWHAZ, ARPC1B, TUBB6, EZR, TUBB4B, TUBA1C, ACTG1, TUBB, OCLN, TUBB4A, TUBA1A, TUBB2B, ARPC5L, ARHGEF2, RHOA, TUBA1B, TUBB2A",0.0716041477432862,0,FALSE
+"H1299","Input","KEGG_PATHWAYS_IN_CANCER",-0.27059,-0.979,0.413,16579,0.706,"TGFBR1, PLCG2, CHUK, GSK3B, PDGFRB, LAMA4, BCR, FN1, WNT11, ERBB2, RASSF5, COL4A6, LAMA1, LAMC1, BMP2, PPARG, ELOB, CBLC, PTGS2, IGF1R, CUL2, CTNNA1, DAPK2, SUFU, SLC2A1, PPARD, FGFR3, IL6, FGF13, EGF, STAT1, CASP8, FH, IKBKB, CDH1, LAMB1, MITF, MMP2, FGFR2, HIF1A, GLI2, BMP4, ARNT2, WNT5A, LAMA3, STAT3, XIAP, RXRA, EP300, CXCL8, MAPK3, WNT7B, EGLN3, FADD, VEGFA, FOXO1, RAC2, CBLB, KITLG, TRAF4, FLT3LG, VEGFB, COL4A1, NCOA4, EPAS1, STAT5A, DAPK1, RARA, COL4A2, PDGFA, TRAF6, RALA, JUP, STAT5B, ARAF",0.384049948343599,0.151195298948196,FALSE
+"H1299","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.32055,-1.15,0.231,9885,0.56,"UGT2B11, UGT2B17, UGT2B4, UGDH, AKR1B1, UGP2, UGT2A1, UGT2A3, UGT2B15, CRYL1, UGT2B7, DCXR, DHDH",0.636388020107856,0.2518119729938,FALSE
+"H1299","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.32056,-1.15,0.242,16980,0.56,"PGM1, H6PD, RBKS, TKT, G6PD, TALDO1, ALDOC",0.616184634019569,0.2518119729938,FALSE
+"H1299","Input","KEGG_PEROXISOME",-0.24,-0.883,0.572,14162,0.767,"PEX11B, SLC25A17, PXMP2, SLC27A2, EHHADH, ACSL1, PHYH, ACOX1, ACAA1, PEX11A, FAR1, PEX6, HMGCL, PIPOX, DDO, MVK, MPV17L, PRDX5, ABCD3, ACSL5, SCP2, IDH1, CAT, PEX12, NUDT12, DHRS4, IDH2",0.242603971206976,0.115204636051019,FALSE
+"H1299","Input","KEGG_PHENYLALANINE_METABOLISM",-0.4242,-1.54,0.0493,11410,0.319,"TAT, AOC3, PAH, AOC2, DDC, MAOA, IL4I1, PRDX6, MAOB, ALDH3B2, ALDH1A3, ALDH3A1",1.30715308072277,0.496209316942819,FALSE
+"H1299","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.1855,0.639,0.96,4331,1,"PIK3CG, IMPA1, PLCD4, INPP5E, CALM1, PIKFYVE, PLCB4, PIK3CB, DGKE, PRKCG, ITPR2, ITPKA, PIK3CD, DGKD, CALM3, INPP5K, SYNJ2, SYNJ1",0.0177287669604316,0,FALSE
+"H1299","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.40441,-1.45,0.0595,14919,0.3,"BLVRA, UGT2B7, HMBS, EARS2, HMOX2, COX15, CP, MMAB, UROS, FTH1",1.22548303427145,0.522878745280338,FALSE
+"H1299","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2951,-1.09,0.308,14313,0.615,"CPT2, CPT1B, SLC27A2, EHHADH, FABP3, AQP7, ACSL1, NR1H3, ACOX1, ACAA1, LPL, CD36, PCK2, OLR1, UBC, PLIN1, PDPK1, PPARG, FADS2, CYP27A1, PPARD, CPT1C, FABP6, ACSL5, SCP2, ME1, PPARA, SORBS1, RXRA",0.511449283499556,0.211124884224583,FALSE
+"H1299","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.27212,-0.987,0.437,13901,0.719,"CH25H, HSD17B4, CYP7B1, CYP27A1, HSD3B7, SCP2",0.359518563029578,0.143271109617117,FALSE
+"H1299","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.16392,0.559,0.986,15984,1,"CD40, TAP2, CD19, UNG, TAP1, RFX5, RFXANK, TNFRSF13C, BTK, JAK3, ADA, ZAP70, RAG2, TNFRSF13B, CD40LG, CD8B, ICOS, CD3E, CD4, AICDA, AIRE, RFXAP, RAG1, DCLRE1C, PTPRC, CD3D, CD79A, CIITA, IGLL1, LCK, IL2RG, IL7R, IKBKG, BLNK, CD8A",0.0061230850587888,0,FALSE
+"H1299","Input","KEGG_PRION_DISEASES",-0.31305,-1.15,0.248,16130,0.56,"IL1A, CCL5, IL1B, PRKACB, NOTCH1, NCAM1, LAMC1, IL6, MAPK3",0.605548319173784,0.2518119729938,FALSE
+"H1299","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.3711,1.26,0.166,3712,0.694,"PIK3CG, HSP90AA1, CCNA1, BUB1, ANAPC4, CCNB1, CPEB1, HSP90AB1, ANAPC13, PLK1, MAD2L2, CCNB2, MAPK11, AKT1, MAPK12, PIK3CB, CDC25C, CDC25A, ANAPC1, CCNA2, PDE3B, AKT2, FZR1, PIK3CD, ANAPC7, ANAPC5, GNAI2",0.779891911959945,0.158640529545145,FALSE
+"H1299","Input","KEGG_PROPANOATE_METABOLISM",-0.46552,-1.7,0.0254,14291,0.319,"ECHS1, EHHADH, ACACA, HIBCH, ACSS3, LDHA, SUCLA2, ABAT, ALDH6A1, ALDH2, PCCA, ACSS1, MCEE",1.59516628338006,0.496209316942819,FALSE
+"H1299","Input","KEGG_PROSTATE_CANCER",-0.23597,-0.855,0.634,15482,0.793,"PDGFRA, MDM2, CCNE1, CREBBP, IKBKG, AR, SOS2, CHUK, GSK3B, PDGFRB, ERBB2, PDPK1, IGF1R, EGF, CREB3L2, IKBKB, FGFR2, EP300, MAPK3, FOXO1, PDGFA, ARAF",0.197910742118267,0.100726812682396,FALSE
+"H1299","Input","KEGG_PROTEASOME",0.39336,1.34,0.136,2638,0.617,"PSMB1, PSMC4, PSMB7, PSMD8, PSMC1, PSMB6, PSMC5, PSMD7, PSMD4, PSMD14, PSMD1, SEM1",0.866461091629782,0.209714835966758,FALSE
+"H1299","Input","KEGG_PROTEIN_EXPORT",-0.55924,-2.02,0.00529,15585,0.282,"SEC61B, SEC62, IMMP1L, SRP9, SRP54, SEC61G, OXA1L, SRP72, SPCS2",2.27654432796481,0.549750891680639,FALSE
+"H1299","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.43501,-1.59,0.0545,13639,0.289,"ATP1B2, ATP1A2, FXYD2, GLS2, GLUD2, PCK2, AQP1, GLS, SLC38A3, ATP1A1, SLC4A4, MDH1",1.26360349772336,0.539102157243452,FALSE
+"H1299","Input","KEGG_PURINE_METABOLISM",0.28487,0.995,0.424,3713,1,"AK5, POLR2D, NPR2, NME2, APRT, NT5E, AK4, POLR1E, POLA1, PRIM1, POLR3G, NME6, PFAS, PDE6D, PDE4A, PDE4C, POLR2I, POLR2A, POLE3, ENTPD5, AMPD2, POLE2, GMPS, NT5M, IMPDH2, NME1, POLR2K, POLD1, PDE3B, POLE, RRM2, PDE6B, RRM2B, GART, PRIM2, NUDT2, NME4, PNPT1, POLR2J, POLR2E",0.372634143407267,0,FALSE
+"H1299","Input","KEGG_PYRIMIDINE_METABOLISM",0.37526,1.29,0.151,4271,0.659,"POLR2D, DHODH, NME2, DTYMK, NT5E, POLR1E, POLA1, PRIM1, POLR3G, TYMS, NME6, POLR2I, POLR2A, DUT, POLE3, ENTPD5, POLE2, CAD, NT5M, NME1, POLR2K, POLD1, POLE, UMPS, RRM2, RRM2B, PRIM2, NUDT2, NME4, PNPT1, POLR2J, POLR2E, TXNRD2, UCK2, POLR3H, POLR1C, CTPS1",0.821023052706831,0.18111458540599,FALSE
+"H1299","Input","KEGG_PYRUVATE_METABOLISM",-0.27126,-1.01,0.378,17768,0.712,"HAGH, MDH1, ME1, PC, ALDH2, ACSS1",0.422508200162775,0.147520006363144,FALSE
+"H1299","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.16551,0.572,0.992,4043,1,"PIK3CG, ITGAM, PAK4, ITGA4, ITGA10, PXN, PFN1, ARPC1A, FGF5, MYLK2, ITGA6, FGF12, PIKFYVE, PAK2, F2R, BCAR1, APC2, MAP2K2, ARPC1B, PIK3CB, PTK2, TIAM1, FGF11, CRK, EZR, PPP1CC, WASF1, RAC3, RRAS, PPP1R12A, MYH10, MYL9, PIK3CD, FGF1, NRAS, ACTG1, VCL, MYL12A, CFL2, FGD1, FGFR1, ITGA2, MYL12B, WASF2",0.00348832784582135,0,FALSE
+"H1299","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.26931,0.924,0.532,4083,1,"IFNA13, PIK3R4, ATG7, ATG12, GABARAPL2, ATG5, ATG4B, ULK3",0.274088367704952,0,FALSE
+"H1299","Input","KEGG_RENAL_CELL_CARCINOMA",-0.31509,-1.14,0.252,17178,0.569,"ELOB, CUL2, SLC2A1, PAK6, FH, HIF1A, ARNT2, EP300, RAP1A, GAB1, MAPK3, EGLN3, VEGFA, VEGFB, EPAS1, ARAF",0.598599459218456,0.244887733604929,FALSE
+"H1299","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.31974,1.08,0.33,4412,1,"THOP1, MME, ANPEP, ENPEP, NLN",0.481486060122112,0,FALSE
+"H1299","Input","KEGG_RETINOL_METABOLISM",-0.28171,-1.01,0.427,11816,0.712,"CYP2C19, UGT2B15, CYP2A7, CYP2C9, RPE65, CYP26C1, CYP2B6, CYP26A1, CYP3A4, CYP4A22, ADH1C, CYP2C18, DHRS3, CYP2A6, PNPLA4, CYP3A7, UGT2B7, CYP1A1, DHRS9, BCO1, RETSAT, RDH12, RDH16, CYP3A5, ALDH1A1, CYP26B1, DHRS4, DHRS4L2",0.369572124974976,0.147520006363144,FALSE
+"H1299","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.51304,-1.91,0.0148,13276,0.235,"ENPP3, ACP4, MTMR7, FLAD1, ACP1, ACP5, ACP2, ACP6, MTMR6",1.82973828460504,0.628932137728264,TRUE
+"H1299","Input","KEGG_RIBOSOME",0.33746,1.15,0.262,5670,0.842,"RPS20, RPL7, RPL13, RPS12, RPS16, RPL26L1, RPL8, RPL35A, RPL30, RPS4X, RPS10, RPSA, RPS19, RPS28, RPL18A, RPS15, UBA52, RPL9, RPL22, RPL29, RPL17, RPL11, MRPL13, RPL35, RPL14, RPS26, RPL41, RPL6, RPL31, RPL5, RPS21, RPS6, RPL3, RPS23, RPS7, RPLP0, RPS27A, RPL4, RPL38, RPL32, RPL37A, RPS9, RPL34, RPL26, RPS25",0.581698708680255,0.0746879085003505,FALSE
+"H1299","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.2561,-0.954,0.461,16349,0.711,"DDX3Y, CYLD, OTUD5, CHUK, MAPK13, CASP8, IKBKB, MAVS, CXCL8, IKBKE, FADD, DHX58, CASP10, MAP3K1, TRAF6",0.336299074610352,0.148130399270234,FALSE
+"H1299","Input","KEGG_RNA_DEGRADATION",0.38539,1.33,0.136,5451,0.602,"HSPD1, PAPOLA, SKIV2L, LSM7, EDC4, LSM2, DCP2, EXOSC10, EXOSC3, EXOSC5, EXOSC2, ENO1, CNOT9, CNOT7, PNPT1, EXOSC4, HSPA9, LSM3, CNOT3, LSM6, MTREX, ZCCHC7, MPHOSPH6, DCP1B, LSM4, LSM1, EXOSC7, EXOSC6",0.866461091629782,0.220403508742175,FALSE
+"H1299","Input","KEGG_RNA_POLYMERASE",0.40475,1.39,0.106,4238,0.588,"POLR2D, POLR1E, POLR3G, POLR2I, POLR2A, POLR2K, POLR2J, POLR2E, POLR3H, POLR1C",0.97469413473523,0.230622673923862,FALSE
+"H1299","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.31319,-1.11,0.264,14276,0.596,"GGT6, GGT5, MAT1A, HEMK1, CTH, LCMT1, GGT1, LCMT2, AHCYL1",0.578396073130169,0.224753740259764,FALSE
+"H1299","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.21331,0.732,0.848,3546,1,"PIK3CG, LAMC3, TRAF3, BIRC3, PIAS3, ITGA6, TRAF1, E2F2, AKT1, CDKN2B, PIK3CB, E2F3, PTK2, CDK6, CKS1B, AKT2, TRAF2, PIAS4, PIK3CD, NFKB1",0.0716041477432862,0,FALSE
+"H1299","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.35173,-1.3,0.128,15917,0.393,"STX3, STX19, SNAP23, BNIP1, STX17, SEC22B, SNAP47, GOSR2, STX12, GOSR1, VAMP8, VAMP5, BET1L, STX6",0.892790030352132,0.405607449624573,FALSE
+"H1299","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2691,-0.998,0.405,14043,0.705,"NEU4, GLA, KDSR, DEGS2, GAL3ST1, SGPP2, SMPD1, DEGS1, GBA, ACER3, PLPP3, GLB1, SGPL1, ARSA, ASAH1",0.392544976785331,0.151810883008601,FALSE
+"H1299","Input","KEGG_SPLICEOSOME",0.49538,1.68,0.03,4233,0.411,"SNRPD2, SF3B5, SNRPC, BUD31, DHX16, DHX38, MAGOHB, HSPA1L, HSPA8, PUF60, WBP11, SNW1, RBM8A, HNRNPA1, SART1, HSPA1A, LSM7, ALYREF, HSPA1B, CTNNBL1, U2SURP, PRPF8, PRPF6, DDX39B, LSM2, XAB2, HNRNPM, RBM22, SNRPF, CDC40, PRPF31, TRA2B, HNRNPU, RBM25, SNRNP200, TCERG1, SF3B4, SRSF9, DHX15, SNRNP40, SYF2, ISY1, SNRPA, SNRPG, SNRPB, PPIL1, HNRNPK, DDX23, SF3A1, SF3A3, SF3A2, PRPF4, TXNL4A, SRSF1, HNRNPA3, CDC5L, LSM3, HSPA2, SNRPA1, U2AF1",1.52287874528034,0.386158178123931,FALSE
+"H1299","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.17176,-0.624,0.969,9337,0.975,"UGT2B10, SI, AMY2B, UGT2B11, GBA3, UGT2B17, AMY1C, AMY1A, UGT2B4, UGDH, HK3, GAA, GBE1, UGP2, G6PC2, UGT2A1, UGT2A3, UGT2B15, MGAM, ENPP3, PYGM, TREH, HK2, UXS1, PGM2L1, UGT2B7, AGL, PGM1, GYS1, HK1",0.0136762229492347,0.0109953843014632,FALSE
+"H1299","Input","KEGG_STEROID_BIOSYNTHESIS",-0.58004,-2.13,0.00831,15796,0.242,"DHCR7, NSDHL, DHCR24, LIPA, SC5D, MSMO1",2.08039897621589,0.616184634019569,TRUE
+"H1299","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.30917,-1.12,0.27,14742,0.587,"AKR1C2, CYP3A7, CYP19A1, SRD5A1, UGT2B7, CYP1A1, CYP7B1, HSD17B2, CYP3A5, HSD11B2, SRD5A3, STS, AKR1C1, HSD17B12, AKR1C3",0.568636235841013,0.231361898752386,FALSE
+"H1299","Input","KEGG_SULFUR_METABOLISM",-0.35104,-1.29,0.152,16556,0.388,"SULT1A2, BPNT1, SULT1A1",0.818156412055227,0.411168274405793,FALSE
+"H1299","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.26652,-0.955,0.482,11568,0.719,"IL10, C5, FCGR2B, FCGR2C, ACTN2, C6, CD86, CTSG, GRIN2A, SNRPD3, TNF, FCGR1A, ELANE, FCGR2A, C2, SNRPD1, C3, TRIM21, C1S, C1R",0.31695296176115,0.143271109617117,FALSE
+"H1299","Input","KEGG_TASTE_TRANSDUCTION",0.46914,1.62,0.0403,2683,0.394,"CACNA1A, SCNN1G, CACNA1B, TAS2R43, TAS2R8, SCNN1B, TAS2R14, TAS2R40, TAS2R46, TAS2R50, TAS2R19, GNB3, TAS2R20, TAS2R10",1.39469495385889,0.404503778174426,FALSE
+"H1299","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.40719,1.4,0.088,1279,0.613,"CDO1, GAD1",1.05551732784983,0.212539525481585,FALSE
+"H1299","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.34964,-1.25,0.198,16796,0.43,"MVK, HMGCS1, GGPS1",0.703334809738469,0.366531544420413,FALSE
+"H1299","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.19662,-0.696,0.886,14662,0.983,"THBS2, CHRD, PPP2R1A, TNF, BMPR1A, RBL2, ACVRL1, CREBBP, RPS6KB2, THBS1, TGFBR1, INHBE, INHBB, BMP2, SMAD7, TFDP1, SKP1, INHBA, SMAD6, LTBP1, FST, BMP4, EP300, MAPK3, SMAD5",0.0525662781129492,0.00744648216786438,FALSE
+"H1299","Input","KEGG_THYROID_CANCER",-0.35324,-1.29,0.149,17134,0.388,"PPARG, CDH1, RXRA, MAPK3, NCOA4",0.826813731587726,0.411168274405793,FALSE
+"H1299","Input","KEGG_TIGHT_JUNCTION",0.18362,0.635,0.956,4356,1,"MYH15, PARD6A, CSNK2B, CLDN20, PPP2R2C, JAM3, AKT1, YBX3, RAB3B, PRKCG, CLDN15, EPB41L2, MPDZ, SYMPK, AKT2, RRAS, LLGL1, MYH10, MYL9, TJAP1, SPTAN1, MYH3, NRAS, ACTG1, CGN, MYL12A, GNAI2, PRKCZ, OCLN, MYL12B, PRKCE, AFDN, MAGI1",0.0195421077238999,0,FALSE
+"H1299","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29954,-1.09,0.295,16314,0.615,"CCL5, IL1B, TAB1, CHUK, TLR2, LY96, TLR4, TLR1, IRF5, MAPK13, IL6, TLR5, TIRAP, STAT1, CASP8, IKBKB, TOLLIP, TICAM2, MAP2K6, TLR3, CXCL8, MAPK3, IKBKE, FADD, MAP3K8, TRAF6, MYD88",0.530177984021837,0.211124884224583,FALSE
+"H1299","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.43404,-1.61,0.0345,12346,0.283,"INMT, GCDH, CYP1B1, WARS2, ACMSD, DDC, MAOA, AANAT, ECHS1, AOC1, AADAT, EHHADH, IL4I1, IDO1, HAAO, KMO, MAOB, CYP1A1, HADH, TDO2, KYNU, CAT, ALDH2",1.46218090492673,0.54821356447571,FALSE
+"H1299","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29037,1.01,0.402,403,1,"PIK3CG, CACNA1A, GCK, CACNA1B",0.39577394691553,0,FALSE
+"H1299","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.25106,0.852,0.626,1279,1,"HSPD1, GAD1",0.20342566678957,0,FALSE
+"H1299","Input","KEGG_TYROSINE_METABOLISM",-0.2501,-0.909,0.553,11110,0.756,"DBH, DCT, TAT, AOC3, COMT, TYR, AOC2, TPO, DDC, MAOA, ADH1C, TH, IL4I1, TYRP1, HEMK1, MAOB, ALDH3B2, HGD, GSTZ1, LCMT1, ALDH1A3, ALDH3A1, LCMT2",0.257274868695302,0.121478204498793,FALSE
+"H1299","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.19907,0.686,0.907,2189,1,"PIK3CG, MAP3K14, PAK4, NFKBIB, FOS, PAK2, MAP3K7, MAPK11, AKT1, MAP2K2, MAPK12, NFKBIE, PIK3CB",0.0423927129399047,0,FALSE
+"H1299","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.28473,-1.06,0.358,16976,0.634,"CDC16, TRIM32, KLHL9, FBXW8, UBOX5, ELOB, CBLC, CUL2, SKP1, ANAPC10, MGRN1, SIAH1, BTRC, UBE2I, XIAP, UBE2F, UBE2H, MID1, SYVN1, DET1, UBE2A, UBE2L6, CBLB, MAP3K1, UBA7, FBXW7, TRAF6, COP1, UBE2E1",0.446116973356126,0.197910742118267,FALSE
+"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.62788,2.16,0.00314,4488,0.266,"VARS2, PDHB, BCAT1, PDHA1",2.50307035192679,0.575118363368933,FALSE
+"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.43423,-1.52,0.0706,14291,0.302,"ECHS1, EHHADH, IL4I1, DBT, HIBCH, ACAA1, HADHB, HMGCL, OXCT1, MCCC1, HADH, HMGCS1, ABAT, ALDH6A1, ALDH2, PCCA, MCEE, HIBADH",1.1511952989482,0.519993057042849,FALSE
+"H1299","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.19437,-0.708,0.879,14244,0.976,"ADRA1D, EDNRA, PRKCA, MYLK3, GUCY1A1, ITPR3, CALCRL, PLA2G10, MYL6, CACNA1D, PRKCH, ADCY4, ACTG2, CACNA1C, ADCY9, ITPR1, PRKCD, ADCY5, GNAQ, PRKACB, PPP1R12B, ADCY6, ADCY1, RAMP2, PLCB2, RAMP1, ADCY7, PLA2G4A, MAPK3, PLA2G12A, PPP1CB, ARAF",0.0560111249262281,0.0105501823333082,FALSE
+"H1299","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.32427,-1.22,0.183,16749,0.468,"PRKACB, ADCY6, ARHGDIB, RAB5A, AQP3, CREB3L2, RAB5B, DYNLL2, DCTN5, DCTN6, RAB5C",0.737548910269571,0.329754146925876,FALSE
+"H1299","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.20612,-0.741,0.801,16606,0.968,"PLCG2, SRC, NFATC2, PTGS2, MAPK13, PLA2G4A, MAPK3, VEGFA, RAC2, PLA2G12A, MAPKAPK2, PPP3CB",0.0963674839157623,0.0141246426916063,FALSE
+"H1299","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.35939,-1.32,0.134,12681,0.396,"MUC2, CFTR, ATP6V0D1, ATP6V1G3, KCNQ1, PDIA4, ATP6V0D2, PRKCA, ATP6V1C2, ACTB, SLC12A2, ATP6V0A1, SEC61B, ADCY9, ATP6V1E1, ERO1A, ATP6V1A, ATP6V0A4, ATP6V1B2, ATP6V1G2, PLCG2, PRKACB, TJP2, ATP6V1B1, ATP6AP1, SEC61G, ATP6V0E1, KDELR2, ARF1",0.872895201635192,0.402304814074488,FALSE
+"H1299","Input","KEGG_VIRAL_MYOCARDITIS",0.14034,0.481,1,3926,0.999,"MYH15, CD40, ICAM1, RAC3, MYH10, MYH3, ACTG1, EIF4G3, EIF4G1",0,0.000434511774017692,FALSE
+"H1299","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.19241,-0.695,0.881,14778,0.975,"PPP2R1A, NKD1, FZD4, APC, WNT10A, WNT4, WNT7A, CREBBP, RAC1, CAMK2B, DAAM2, CTBP2, DVL3, MMP7, GSK3B, PRKACB, NFATC2, WNT11, LRP5, FRAT1, PORCN, PPARD, PLCB2, SKP1, NLK, PRICKLE2, WNT5A, VANGL2, SIAH1, BTRC, EP300, WNT7B, FRAT2, TBL1XR1, RAC2, DAAM1, PPP3CB",0.0550240915879521,0.0109953843014632,FALSE
+"HCC44","Input","KEGG_ABC_TRANSPORTERS",-0.14437,-0.42,0.999,10995,0.999,"ABCC6, ABCB4, ABCA13, ABCB1, ABCG4, ABCA12, ABCD3, ABCA2, ABCB8, ABCC10, ABCB6, ABCB10, ABCD4, ABCB9",0.000434511774017692,0.000434511774017692,FALSE
+"HCC44","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.39866,-1.16,0.22,14933,0.512,"MAPK1, LEF1, EIF4EBP1, PIK3CA, RPS6KB1, PIM1, TCF7L1, GRB2, KRAS, RELA, IKBKB, PML, SOS1, RPS6KB2, HRAS, MAPK3, PIK3R2, BAD",0.657577319177794,0.290730039024169,FALSE
+"HCC44","Input","KEGG_ADHERENS_JUNCTION",-0.26087,-0.763,0.863,12186,1,"WASL, TCF7L2, NECTIN1, CSNK2A1, SSX2IP, PARD3, RAC3, CREBBP, RHOA, INSR, IQGAP1, LMO7, ACP1, SORBS1, CDC42, MAPK1, LEF1, WASF2, CTNND1, TCF7L1, WASF3, FARP2, PTPN1, ERBB2, SRC, MAPK3",0.0639892042847904,0,FALSE
+"HCC44","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.26187,-0.764,0.84,11172,1,"PRKAB2, PRKAB1, TNFRSF1B, SLC2A4, MTOR, AKT2, PTPN11, PPARA, STK11, PRKCQ, AKT1, ACACB, RXRA, PPARGC1A, MAPK10, CPT1C, NFKBIE, ACSL3, MAPK9, CAMKK1, TRADD, CAMKK2, ADIPOR1, RXRB, RELA, IKBKB, CPT1B, ACSL1, PRKAG1",0.0757207139381184,0,FALSE
+"HCC44","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.23418,-0.687,0.925,14681,1,"GPT, GFPT1, CPS1, ABAT, ALDH5A1, GLUL, NIT2, GOT1",0.0338582672609674,0,FALSE
+"HCC44","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.27633,-0.811,0.795,8977,1,"PIK3CG, FXYD2, NEDD4L, PIK3R5, IGF1, HSD11B1, SCNN1G, ATP1B2, PIK3CD, KCNJ1, SCNN1A, PRKCA, SCNN1B, PIK3CB, PRKCG, PIK3R3, INSR, NR3C2, PIK3R1, MAPK1, PDPK1, PIK3CA, KRAS, MAPK3, PIK3R2",0.0996328713435297,0,FALSE
+"HCC44","Input","KEGG_ALLOGRAFT_REJECTION",0.53632,1.94,0.02,362,0.14,"TNF, IL2, IL12B",1.69897000433602,0.853871964321762,TRUE
+"HCC44","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.56047,-1.65,0.0147,17652,0.115,"PLA2G4B, PLA2G6, ACOX1, PLA2G12A",1.83268266525182,0.939302159646388,TRUE
+"HCC44","Input","KEGG_ALZHEIMERS_DISEASE",-0.57556,-1.69,0.00741,15313,0.105,"GAPDH, LRP1, NDUFB2, PPP3CB, PPP3CC, PSEN2, UQCRC1, SDHB, APBB1, IDE, NDUFA9, ADAM10, NDUFS4, COX7B, NDUFV2, ATP5PF, GSK3B, NDUFS5, CASP3, NDUFA3, ATP5PB, NDUFB9, SDHD, SDHC, FADD, COX6B1, COX7A2L, UQCRQ, CALM2, UQCRFS1, APH1A, UQCRC2, CYC1, NDUFB7, CHP1, NDUFB1, UQCR11, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, GNAQ, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, HSD17B10, NDUFV1, CDK5, NDUFB8, NDUFB4, NDUFC2, ATP5F1C, MAPK3, CALM3, CAPN1, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, PLCB3, NDUFA2, NDUFS3, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, BAD, COX8A, NDUFB3",2.13018179202067,0.978810700930062,TRUE
+"HCC44","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.50591,-1.48,0.0371,13716,0.199,"VARS2, EARS2, CARS2, TARS2, DARS2, FARS2, PARS2, IARS2, AARS2, SEPSECS, HARS2, MTFMT, NARS2",1.43062609038495,0.701146923590293,TRUE
+"HCC44","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.47665,-1.4,0.0589,14409,0.26,"NPL, CMAS, GNE, GALK1, GPI, GFPT1, UXS1, CYB5R3, GMPPB, CYB5R1, GNPDA1, GALK2, AMDHD2, NAGK, PMM1, UGP2, GMPPA, MPI, GALT, FPGT",1.2298847052129,0.585026652029182,FALSE
+"HCC44","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.40414,-1.19,0.183,14202,0.491,"MAPK14, DERL1, ALS2, BCL2L1, BAX, PPP3CB, PPP3CC, DAXX, TOMM40L, CAT, CASP3, MAP2K6, SOD1, CHP1, MAPK11, TP53, APAF1, CCS, BAD",0.737548910269571,0.308918507877032,FALSE
+"HCC44","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.29309,1.12,0.208,1630,0.611,"KLRC2, CD74, HSPA6, KLRC3, HSPA1B, HSPA5, HSPA1A, IFNA1, PSME1, TAPBP, TAP2, LGMN",0.681936665037238,0.213958789757446,FALSE
+"HCC44","Input","KEGG_APOPTOSIS",-0.27951,-0.821,0.774,14098,1,"PRKACA, PIK3R1, FAS, AIFM1, BCL2L1, PRKAR1A, BAX, PPP3CB, PPP3CC, PRKAR2B, TRADD, PIK3CA, CASP3, IRAK4, FADD, RELA, IKBKB, CHP1, ENDOG, PRKX, CASP6, TP53, PIK3R2, CAPN1, APAF1, BAD",0.111259039317107,0,FALSE
+"HCC44","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.17975,-0.523,0.995,17627,1,"PTGES2, PLA2G4B, LTA4H, PLA2G6, PLA2G12A",0.00217691925427455,0,FALSE
+"HCC44","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.29107,-0.857,0.708,11735,1,"GLUD1, GLUD2, GOT2, PYCR1, P4HA1, GLS2, ALDH18A1, GATM, ALDH7A1, CKMT1A, CKMT1B, PRODH, NOS3, SAT2, LAP3, CPS1, SMS, PYCR2, OAT, ALDH9A1, GLUL, AZIN2, GOT1, GAMT, PYCR3",0.149966742310231,0,FALSE
+"HCC44","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.20439,-0.592,0.973,9327,1,"LAMA2, SGCG, CACNA2D3, ITGA11, SGCB, CTNNA2, CTNNA1, SGCD, SGCA, CACNG7, ITGA10, CACNA1C, CACNB2, ITGA9, ACTN2, CACNA2D2, ITGA6, RYR2, DAG1, CACNG6, TCF7L2, CACNA1D, CACNB4, CACNG8, ITGA4, ITGB6, ITGA2B, SLC8A1, LMNA, CACNG4, LEF1, ITGA7, CACNA2D1, PKP2, DMD, ITGB8, EMD, CDH2, TCF7L1, CACNB3",0.0118871597316481,0,FALSE
+"HCC44","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.15866,-0.472,0.999,16830,1,"ALDH9A1",0.000434511774017692,0,FALSE
+"HCC44","Input","KEGG_ASTHMA",0.44335,1.77,0,2492,0.191,"TNF, IL13, CD40, PRG2, FCER1A",Inf,0.718966632752272,TRUE
+"HCC44","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.33423,1.26,0.15,9163,0.503,"IL2, IFNA1, CD40, IFNA4, IFNA17, IFNA6, IFNA16, CD28, FASLG, IFNA10, IFNA2, IFNA7, IFNA14, CD40LG, CD80, IL10, TSHB, IFNA13, IL4, CTLA4, CD86, IFNA21, CGA, PRF1, IFNA8, GZMB, TPO, IFNA5, TSHR",0.823908740944319,0.298432014944073,FALSE
+"HCC44","Input","KEGG_AXON_GUIDANCE",-0.3119,-0.918,0.612,11084,0.981,"EPHB1, NRAS, CXCL12, ROBO2, PLXNB1, GNAI2, EPHA3, NTN1, DPYSL5, ABLIM2, SEMA3C, EPHA6, SEMA6D, UNC5A, ARHGEF12, UNC5B, NGEF, ROBO1, FES, SLIT3, SEMA6A, EFNA2, RAC3, RHOA, EPHB4, SLIT2, CXCR4, SEMA3D, NFATC3, SEMA4A, SEMA3E, PLXNB2, EFNB3, PLXNB3, PTK2, SEMA5A, GNAI3, PAK4, EPHA1, ROBO3, CDC42, SEMA6C, MAPK1, RASA1, PAK6, NFATC4, EFNB1, PPP3CB, SEMA4D, PPP3CC, SEMA4C, SRGAP3, SEMA4G, DPYSL2, EPHA4, EPHB3, GSK3B, PAK1, EFNA4, RGS3, KRAS, LIMK2, EFNA3, CHP1, NCK2, SEMA4F, CFL1, CDK5, HRAS, MAPK3, SRGAP2",0.213248577854439,0.0083309926200515,FALSE
+"HCC44","Input","KEGG_BASAL_CELL_CARCINOMA",-0.29998,-0.877,0.681,12191,1,"HHIP, FZD8, WNT4, TCF7L2, PTCH1, FZD3, WNT10A, FZD7, AXIN2, WNT10B, GLI1, BMP4, FZD4, LEF1, DVL3, APC, FZD2, GSK3B, AXIN1, STK36, TCF7L1, DVL2, SMO, SUFU, TP53",0.166852888087215,0,FALSE
+"HCC44","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.40519,-1.19,0.212,13676,0.491,"TBPL1, GTF2E1, TAF11, TAF2, TAF7, TAF9B, STON1, GTF2E2, GTF2B, TAF6, TAF10, TAF1, TAF6L, TAF5, GTF2A2",0.673664139071249,0.308918507877032,FALSE
+"HCC44","Input","KEGG_BASE_EXCISION_REPAIR",-0.57625,-1.69,0.00953,12329,0.105,"NEIL1, XRCC1, APEX1, PARP2, POLD1, POLE, PCNA, LIG3, POLE4, MUTYH, FEN1, PARP3, APEX2, POLD3, SMUG1, POLD4, MPG, NEIL3, UNG, LIG1, POLL, NEIL2, OGG1, NTHL1, POLB",2.02090709936167,0.978810700930062,TRUE
+"HCC44","Input","KEGG_BETA_ALANINE_METABOLISM",-0.40672,-1.19,0.187,15448,0.491,"ABAT, SMS, HADHA, EHHADH, ALDH9A1, ECHS1, HIBCH",0.728158393463501,0.308918507877032,FALSE
+"HCC44","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.44375,-1.28,0.118,13525,0.367,"HSD17B12, ELOVL2, HACD2, ACOT7, TECR, ACAA1, HADHA, SCD5, ACOX1, PECR",0.928117992693875,0.435333935747911,FALSE
+"HCC44","Input","KEGG_BLADDER_CANCER",-0.31503,-0.918,0.598,14933,0.981,"MAPK1, CDK4, DAPK1, MDM2, KRAS, E2F1, E2F2, ERBB2, HRAS, TP53, MAPK3, VEGFB",0.223298816011589,0.0083309926200515,FALSE
+"HCC44","Input","KEGG_BUTANOATE_METABOLISM",-0.49672,-1.45,0.041,12914,0.211,"L2HGDH, BDH2, ALDH7A1, AACS, ACAT2, ABAT, ALDH5A1, HADHA, EHHADH, HMGCL, ALDH9A1, HMGCS1, PDHB, ECHS1, ACADS, HADH, PDHA1, ACAT1",1.38721614328026,0.675717544702307,TRUE
+"HCC44","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31521,-0.922,0.61,11376,0.99,"PIK3CB, CD81, BLNK, BCL10, VAV2, MAP2K1, AKT2, INPP5D, PIK3R3, RAC3, SOS2, IFITM1, AKT1, NFATC3, SYK, PIK3AP1, PIK3R1, LILRB3, MAPK1, VAV3, CD72, NFATC4, NFKBIE, PPP3CB, PPP3CC, PLCG2, PIK3CA, GSK3B, GRB2, KRAS, RELA, IKBKB, CHP1, SOS1, HRAS, MAPK3, PIK3R2",0.214670164989233,0.00436480540245009,FALSE
+"HCC44","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.19988,-0.582,0.983,12473,1,"F2R, P2RX6, PDE1C, PRKCG, PLCD4, CAMK2B, RYR1, ATP2A1, CACNA1D, CACNA1H, PDGFRB, TBXA2R, CALML6, ADRA1B, TNNC1, CHRM3, PRKACA, CALM1, SLC8A1, CHRNA7, VDAC1, PLCB4, NOS3, GNA11, CAMK4, PHKB, GNAL, ERBB3, PPID, ITPKA, P2RX4, PHKG2, PPP3CB, PPP3CC, PLCG2, CAMK2D, ITPKB, VDAC2, ADCY9, SLC25A4, PHKA2, CAMK2G, CALM2, SLC25A6, CHP1, ERBB2, PLCD1, PLCG1, GNAQ, PRKX, SPHK2, VDAC3, CALM3, PLCB3",0.00744648216786438,0,FALSE
+"HCC44","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.44629,-1.3,0.11,13704,0.35,"TNNC1, CACNB4, CACNG8, UQCRH, COX7A2, SLC8A1, TNNI3, CACNG4, CACNA2D1, UQCRC1, COX7B, SLC9A6, TPM3, COX6B1, COX7A2L, UQCRQ, UQCRFS1, UQCRC2, CYC1, UQCR11, UQCRHL, COX5A, COX7C, UQCR10, COX6A1, CACNB3, COX5B, COX6C, UQCRB, COX8A",0.958607314841775,0.455931955649724,FALSE
+"HCC44","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.18511,0.738,0.945,1943,0.914,"ITGB2, CD274, PVR, ICAM1, PDCD1LG2, ICAM2, SELPLG, CLDN1, PTPRF, CD58, NEGR1, SDC4, ITGAV, ALCAM, ITGB1, CD40, CLDN4",0.0245681914907371,0.0390538042661686,FALSE
+"HCC44","Input","KEGG_CELL_CYCLE",-0.50846,-1.49,0.0341,12645,0.194,"TFDP2, STAG2, DBF4, ANAPC4, ORC5, TGFB3, SKP2, RBL2, CREBBP, PTTG2, CDK7, CDC14B, ANAPC1, ORC6, MAD2L2, RBL1, CDC26, ANAPC10, CHEK2, MCM4, BUB3, HDAC1, PCNA, YWHAQ, WEE1, ZBTB17, MCM2, CDK2, CDC20, CCND3, SMC1A, MCM6, CDC14A, CDK4, YWHAH, ANAPC5, ANAPC7, SKP1, MCM3, YWHAE, GSK3B, CDKN2C, PTTG1, MDM2, CDC45, ORC2, CCNB1, MCM5, YWHAZ, CDKN1B, ANAPC11, FZR1, SMC3, CDC23, ORC3, ORC4, E2F1, TTK, ORC1, CHEK1, E2F2, CDC27, CDC25B, PLK1, CCNA2, YWHAB, BUB1, CCNB2, MAD2L1, CDKN2D, TP53, CDK1, BUB1B, ESPL1, RBX1, CDC25C, RAD21, PKMYT1",1.4672456210075,0.712198270069774,TRUE
+"HCC44","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.19876,-0.59,0.973,11825,1,"ADCY5, VAV2, MAP2K1, PREX1, JAK3, PRKCD, AKT2, CXCR6, WASL, GRK7, GRK4, GNG2, GNG13, GNG5, CCL28, PIK3R3, PARD3, SHC3, CCL27, SOS2, RHOA, GNG7, GNB5, SHC2, CXCR4, AKT1, RASGRP2, CCL2, PRKACA, TIAM2, PIK3R1, RAP1A, PTK2, PLCB4, GNAI3, PRKCZ, ADCY6, CDC42, MAPK1, VAV3, CCR10, GRK5, CRKL, PIK3CA, ARRB1, GSK3B, ADCY9, STAT1, GRK2, PAK1, GRB2, KRAS, RELA, STAT2, IKBKB, GNB2, SOS1, GRK6, PRKX, ARRB2, HRAS, CSK, MAPK3, PIK3R2, PLCB3",0.0118871597316481,0,FALSE
+"HCC44","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.37997,-1.11,0.29,12387,0.605,"ARAF, PTPN11, PIK3R3, SHC3, SOS2, TGFB3, CBLC, SHC2, AKT1, CTBP2, PIK3R1, HDAC1, CBL, BCR, MAPK1, BCL2L1, CDK4, CRKL, PIK3CA, GAB2, MDM2, CDKN1B, GRB2, KRAS, RELA, E2F1, IKBKB, E2F2, SOS1, CTBP1, HRAS, TP53, MAPK3, PIK3R2, BAD",0.537602002101044,0.218244625347531,FALSE
+"HCC44","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.19943,-0.584,0.976,17357,1,"CRY2",0.0105501823333082,0,FALSE
+"HCC44","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.52036,-1.55,0.0203,14250,0.153,"DLAT, OGDH, OGDHL, SUCLA2, IDH2, SDHB, FH, SDHD, SDHC, PDHB, IDH1, IDH3A, MDH1, ACO2, PDHA1, SUCLG1",1.69250396208679,0.815308569182401,TRUE
+"HCC44","Input","KEGG_COLORECTAL_CANCER",-0.36807,-1.09,0.31,12342,0.635,"TCF7L2, ARAF, PIK3R3, CASP9, RAC3, MLH1, BCL2, TGFB3, RHOA, AXIN2, AKT1, MSH3, PIK3R1, APPL1, MAPK10, RALGDS, MSH6, MAPK1, LEF1, BAX, APC, MAPK9, PIK3CA, GSK3B, AXIN1, CASP3, TCF7L1, KRAS, BIRC5, TP53, MAPK3, PIK3R2, BAD",0.508638306165727,0.197226274708024,FALSE
+"HCC44","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.43012,1.62,0.0638,1345,0.285,"THBD, CFB, PLAUR, C3, F3, SERPINE1, BDKRB1, TFPI, PLAU, C1S, CD55, C4A, BDKRB2",1.19517932127884,0.54515513999149,FALSE
+"HCC44","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.31599,-0.917,0.606,15274,0.974,"MTR, LDHA, SMS, ADI1, DNMT3B, DNMT3A, ENOPH1, MPST, GOT1, MAT2B",0.217527375833714,0.0114410431213845,FALSE
+"HCC44","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.42205,1.48,0.0769,1980,0.309,"OSM, TNFRSF9, TNFSF11, IL24, IL11, CSF3, CXCL5, TNFRSF18, TNFRSF6B, CXCL6, TNF, CXCL8, IL2, IFNE, CSF2, CXCL2, CCL20, VEGFC, CCL5, CXCL3, IL12B, IL6, TGFB2, BMP2, TNFRSF10D, IL1B, IL15RA, TNFRSF25, IL1A, IL13, TNFRSF10A, INHBE, IL6ST, TGFBR1, CSF1, IL20RB, CCL26, CLCF1, IL6R, IL7R, TNFSF14, CD70, OSMR, CXCR3, IFNA1, XCL1, TNFSF9, TGFB1, KITLG, TNFRSF4, CX3CL1, LTB, IFNGR1, TGFBR2, EGFR, PF4V1, IL2RG, VEGFA, RELT, IL22, TNFRSF12A, MET, IL1RAP, CXCL1, CD40, IL7, IL23A",1.11407366019857,0.510041520575165,FALSE
+"HCC44","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.22063,0.811,0.698,1635,0.848,"CCL5, IL6, IL1B, RIPK1, AIM2, IFNA1, NFKB1, NFKBIA, IKBKG",0.156144577376839,0.0716041477432862,FALSE
+"HCC44","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.16076,-0.463,0.999,9251,1,"MYL2, LAMA2, SGCG, CACNA2D3, ADCY4, ITGA11, IGF1, SGCB, TPM1, SGCD, SGCA, CACNG7, ITGA10, CACNA1C, ADRB1, CACNB2, ITGA9, CACNA2D2, ITGA6, ADCY5, RYR2, DAG1, CACNG6, TNNT2, CACNA1D, TGFB3, TNNC1, CACNB4, CACNG8, ITGA4, ITGB6, PRKACA, ITGA2B, SLC8A1, LMNA, TNNI3, CACNG4, ADCY6, ITGA7, CACNA2D1, DMD, ITGB8, EMD, ADCY9, TPM3, PRKX, CACNB3",0.000434511774017692,0,FALSE
+"HCC44","Input","KEGG_DNA_REPLICATION",-0.58861,-1.7,0.00848,13452,0.114,"POLD1, POLA1, POLE, MCM4, RPA3, PCNA, MCM2, RFC4, MCM6, RFC2, POLE4, RPA2, MCM3, FEN1, RNASEH2A, POLD3, MCM5, RPA1, RFC5, POLD4, PRIM2, LIG1, DNA2, RNASEH2C, POLA2",2.07160414774329,0.943095148663527,TRUE
+"HCC44","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.36954,-1.06,0.359,11539,0.68,"NOTCH4, MAP2K1, SPIRE2, NOTCH3, SOS2, FMN2, CPEB1, MAPK1, GRB2, KRAS, SOS1, MAPK3",0.444905551421681,0.167491087293764,FALSE
+"HCC44","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.19587,-0.573,0.983,5790,1,"UGT2B11, GSTA3, CYP2A7, UGT2B4, CYP2A13, FMO2, ADH1B, ADH7, ADH4, UGT2B17, CYP1A2, FMO1, ADH1A, CYP3A43, UGT2A3, GSTM5, CYP2C19, UGT2B15, CYP2A6, GSTA2, FMO3, CYP2B6, ADH1C, CYP2C9, GSTK1, CYP2C18, CYP2C8, GSTA1, GSTM4, ADH6, MGST2, MAOA, CYP3A5, CYP3A7, CYP3A4, MAOB, UGT2B7, ALDH3B2, CYP2E1, CYP2D6, GSTM1, GSTM2, GSTT2, FMO5, GSTO1, GSTP1, FMO4, GSTA4, ADH5, MGST3",0.00744648216786438,0,FALSE
+"HCC44","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.20452,-0.602,0.965,18592,1,"UCK1, TK1",0.0154726866562074,0,FALSE
+"HCC44","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.26823,0.972,0.333,1952,0.725,"COL4A6, ITGA2, AGRN, TNXB, LAMC2, LAMB3, ITGA1, ITGA5, HSPG2, COL4A2, COL4A1, COL5A1, LAMB1, COL6A2, LAMA5, SDC4, LAMA3, COL6A1, THBS1, RELN, ITGAV, ITGB1, CD44, ITGA3",0.47755576649368,0.139661993429006,FALSE
+"HCC44","Input","KEGG_ENDOCYTOSIS",-0.43834,-1.28,0.116,13127,0.367,"ITCH, CBLC, SH3GL3, CLTB, VPS37B, AP2M1, ACAP1, RAB5A, CXCR4, RAB11FIP5, RAB11FIP3, HSPA1L, CHMP2B, PIP5K1A, AP2A1, EPN3, CBL, RUFY1, PARD6G, CLTC, PDCD6IP, WWP1, DNM3, EEA1, PRKCZ, IQSEC1, RAB4A, MVB12A, CDC42, FGFR2, ERBB3, SH3GLB1, VPS4A, RAB5C, VPS37C, FGFR4, SH3GL1, GRK5, RBSN, PIP4K2B, USP8, PSD, PARD6B, EPN1, ARRB1, RAB11FIP4, CHMP4B, CHMP2A, PARD6A, MDM2, RAB11B, AGAP1, GRK2, STAM2, SH3GLB2, VPS25, STAMBP, IQSEC2, MVB12B, VPS37A, VPS37D, CLTA, PIKFYVE, RNF41, ASAP3, TSG101, SRC, GIT2, SMAP1, CHMP3, GRK6, DNM1L, GIT1, SNF8, CHMP5, ARRB2, HRAS, EPS15, ARFGAP2, PLD2, ARAP1, VPS28, RAB5B, RAB11A",0.935542010773082,0.435333935747911,FALSE
+"HCC44","Input","KEGG_ENDOMETRIAL_CANCER",-0.44413,-1.3,0.111,11157,0.35,"NRAS, APC2, EGF, FOXO3, PIK3CB, MAP2K1, AKT2, TCF7L2, ARAF, PIK3R3, CASP9, MLH1, SOS2, AXIN2, AKT1, PIK3R1, MAPK1, PDPK1, LEF1, APC, PIK3CA, ELK1, GSK3B, AXIN1, TCF7L1, GRB2, KRAS, ERBB2, SOS1, ILK, HRAS, TP53, MAPK3, PIK3R2, BAD",0.954677021213343,0.455931955649724,FALSE
+"HCC44","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.43152,-1.26,0.142,14005,0.391,"JAM3, MAPK14, ATP6V0D1, MAPK10, ATP6V0B, ATP6V1G1, ATP6V0A1, ATP6V1G2, CDC42, ATP6V1B1, ATP6V0E2, PLCG2, MAPK9, ADAM10, ATP6V1A, ATP6V1H, ATP6V0C, CASP3, ATP6V1B2, PAK1, RELA, ATP6V1E1, IKBKB, ATP6V0E1, ATP6V1E2, MAPK11, SRC, PLCG1, ATP6V1C1, GIT1, CSK, ATP6V1F",0.847711655616944,0.407823242604133,FALSE
+"HCC44","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.39089,-1.14,0.246,12707,0.539,"PRKCG, PIK3R3, CAMK2B, SHC3, SOS2, CBLC, SHC2, AKT1, MAP2K7, PIK3R1, PTK2, MAPK10, NRG2, CBL, NRG4, PAK4, MAPK1, ERBB3, PAK6, EIF4EBP1, PLCG2, CRKL, MAPK9, CAMK2D, PIK3CA, ELK1, GSK3B, RPS6KB1, GAB1, PAK1, CDKN1B, CAMK2G, GRB2, KRAS, ERBB2, SOS1, NCK2, SRC, PLCG1, RPS6KB2, HRAS, MAPK3, PIK3R2, BAD",0.609064892896621,0.268411234813261,FALSE
+"HCC44","Input","KEGG_ETHER_LIPID_METABOLISM",-0.40118,-1.18,0.214,17652,0.491,"PLA2G4B, PAFAH1B3, PLA2G6, PAFAH2, PLD2, PLA2G12A",0.669586226650809,0.308918507877032,FALSE
+"HCC44","Input","KEGG_FATTY_ACID_METABOLISM",-0.53442,-1.56,0.0303,14150,0.163,"ECI1, ACADM, ACAT2, CPT1C, ACAA1, ACSL3, HADHA, EHHADH, GCDH, ALDH9A1, ECHS1, ACADS, CPT1B, ACOX1, ACADSB, HADHB, ACSL1, HADH, ADH5, ACAT1",1.5185573714977,0.787812395596042,TRUE
+"HCC44","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.29177,-0.849,0.719,13644,1,"AKT1, SYK, MAP2K7, PIK3R1, MAPK14, MAPK10, MAPK1, VAV3, PDPK1, PLCG2, MAPK9, PIK3CA, GAB2, MAP2K6, GRB2, KRAS, PLA2G4B, SOS1, PLA2G6, MAPK11, PLCG1, HRAS, MAPK3, PIK3R2, PLA2G12A",0.143271109617117,0,FALSE
+"HCC44","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.37069,-1.08,0.343,11163,0.647,"ARPC1A, PLA2G4F, FCGR2A, PIK3CB, WAS, DNM2, VAV2, MAP2K1, PRKCD, AKT2, WASL, SCIN, INPP5D, PRKCG, PIK3R3, MARCKSL1, MARCKS, PLPP1, AKT1, SYK, PIP5K1A, PIK3R1, VASP, ARPC4, DNM3, CDC42, MAPK1, VAV3, PLCG2, CRKL, PIP4K2B, PIK3CA, WASF2, GAB2, RPS6KB1, WASF3, PAK1, ARPC5, LIMK2, ARPC2, PIKFYVE, ASAP3, PLA2G4B, PLA2G6, PLCG1, GSN, RPS6KB2, DNM1L, SPHK2, CFL1, MAPK3, PIK3R2, PLD2, ARPC3",0.464705879957229,0.1890957193313,FALSE
+"HCC44","Input","KEGG_FOCAL_ADHESION",-0.20819,-0.61,0.969,10402,1,"COL6A3, PAK3, VEGFD, XIAP, RASGRF1, CAV1, MYLK3, MAPK8, ROCK1, ITGA10, LAMC3, PTEN, ARHGAP35, COL11A1, COL5A3, PXN, MYL9, MYLK2, ITGA9, ACTN2, EGF, PIK3CB, FLT4, COL1A1, ITGA6, VAV2, MAP2K1, AKT2, THBS2, COL3A1, CCND2, LAMA1, PRKCG, PIK3R3, RAC3, SHC3, SOS2, BCL2, COL11A2, PDGFRB, RHOA, COL1A2, MYLPF, PGF, PDGFC, SHC2, AKT1, TLN1, ITGA4, SPP1, ITGB6, THBS4, ITGA2B, CHAD, PIK3R1, RAP1A, MYL5, VASP, PTK2, MAPK10, PDGFD, PPP1CC, PAK4, CDC42, PDGFB, LAMA4, MAPK1, VAV3, PDPK1, CCND3, COL5A2, PAK6, ITGA7, FN1, CRKL, MAPK9, ITGB8, THBS3, PIK3CA, ELK1, GSK3B, RAPGEF1, PAK1, GRB2, ERBB2, SOS1, ILK, SRC, TLN2, PPP1CB, HRAS, MAPK3, PIK3R2, VEGFB, PPP1CA, BAD",0.0136762229492347,0,FALSE
+"HCC44","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.47339,-1.39,0.0557,14562,0.268,"GGH, QDPR, FPGS, SPR, DHFR",1.25414480482627,0.571865205971211,FALSE
+"HCC44","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.48366,-1.41,0.0647,15857,0.261,"PHPT1, GMPPB, MTMR6, TPI1, PFKL, ALDOA, PMM1, KHK, GMPPA, MPI, FPGT",1.1890957193313,0.583359492661719,FALSE
+"HCC44","Input","KEGG_GALACTOSE_METABOLISM",-0.44266,-1.3,0.113,11743,0.35,"GCK, PGM1, PGM2, HK1, GALE, PFKM, GALK1, B4GALT2, GAA, GLA, GALK2, PFKL, UGP2, GALT, GANC",0.94692155651658,0.455931955649724,FALSE
+"HCC44","Input","KEGG_GAP_JUNCTION",-0.34838,-1.01,0.438,10956,0.806,"DRD2, ADRB1, NRAS, EGF, TUBB8, GNAI2, GUCY1A2, ADCY5, TUBB2A, MAP2K1, PRKG1, PRKCG, GUCY1A1, SOS2, PDGFRB, PDGFC, TUBB4A, TUBA1A, PRKACA, PDGFD, GUCY1B1, PLCB4, GNAI3, TUBB2B, GNA11, ADCY6, PDGFB, MAPK1, MAP3K2, TUBB4B, TUBB, MAPK7, TUBA1B, ADCY9, GRB2, KRAS, SOS1, SRC, MAP2K5, GNAQ, PRKX, HRAS, CDK1, MAPK3, PLCB3",0.3585258894959,0.0936649581949093,FALSE
+"HCC44","Input","KEGG_GLIOMA",-0.39728,-1.16,0.243,11127,0.512,"RB1, NRAS, EGF, PIK3CB, MAP2K1, MTOR, AKT2, ARAF, PRKCG, PIK3R3, CAMK2B, SHC3, SOS2, PDGFRB, SHC2, CALML6, AKT1, PIK3R1, CALM1, PDGFB, MAPK1, CDK4, PLCG2, CAMK2D, PIK3CA, MDM2, CAMK2G, GRB2, KRAS, E2F1, CALM2, E2F2, SOS1, PLCG1, HRAS, TP53, MAPK3, PIK3R2, CALM3",0.614393726401688,0.290730039024169,FALSE
+"HCC44","Input","KEGG_GLUTATHIONE_METABOLISM",-0.28621,-0.833,0.743,12431,1,"GPX7, GSTM2, GPX2, OPLAH, GPX4, GSTT2, GSTO1, RRM1, LAP3, IDH2, GSTP1, TXNDC12, SMS, RRM2, GSS, IDH1, RRM2B, GSTA4, MGST3",0.129011186239425,0,FALSE
+"HCC44","Input","KEGG_GLYCEROLIPID_METABOLISM",0.26218,0.996,0.4,1263,0.704,"GPAT2, AKR1B1, DGKH, GPAT3, PLPP3, DGKG, DGKE, DGAT2, DGKD, GK, DGKI",0.397940008672038,0.152427340857888,FALSE
+"HCC44","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.28063,-0.827,0.779,11448,1,"GPD1, PHOSPHO1, AGPAT3, CHKA, PLA2G10, PCYT1A, PCYT1B, LPCAT3, CDS1, PGS1, LCLAT1, PLPP1, LPCAT4, GPD2, PLA2G15, AGPAT2, ACHE, MBOAT1, ETNK1, LYPLA1, PTDSS2, DGKZ, GNPAT, LPGAT1, DGKQ, ETNK2, DGKA, CHKB, PLA2G4B, PLA2G6, PCYT2, CDS2, LYPLA2, PLD2, PLA2G12A, CDIPT",0.108462542327436,0,FALSE
+"HCC44","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.28303,-0.83,0.78,10800,1,"MAOA, MAOB, SHMT2, GNMT, SARDH, DLD, PSPH, PIPOX, GCAT, GATM, GLYCTK, SRR, GLDC, AMT, PHGDH, ALAS1, SHMT1, GAMT",0.10790539730952,0,FALSE
+"HCC44","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.4332,-1.26,0.144,13390,0.391,"PGK1, ALDH7A1, PFKM, DLAT, BPGM, GALM, PGAM4, GPI, GAPDH, LDHA, AKR1A1, ENO3, TPI1, ALDH9A1, ACSS1, PKM, PDHB, PFKL, ALDOA, ACSS2, PGAM1, PDHA1, ADH5",0.84163750790475,0.407823242604133,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.33629,1.24,0.167,750,0.498,"CSGALNACT1, CHSY1, B3GALT6, CHST11, CHPF2, DSE",0.777283528852417,0.302770657240282,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.25001,-0.735,0.897,11027,1,"NDST3, B3GAT1, GLCE, EXT2, HS3ST3A1, NDST1, XYLT1, HS3ST3B1, EXTL3, B4GALT7, HS6ST1, XYLT2, NDST2, B3GAT3",0.0472075569559079,0,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.29609,-0.875,0.685,13130,1,"B3GNT7, CHST6, B4GALT2, B4GALT3, B4GAT1, B4GALT4",0.164309428507574,0,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.34584,-1.01,0.427,11770,0.806,"IDUA, HYAL1, HS3ST3A1, HYAL2, HS3ST3B1, HEXB, GALNS, HYAL3",0.369572124974976,0.0936649581949093,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.26843,1.03,0.333,13985,0.699,"ST3GAL1, SLC33A1, ST3GAL2, GLB1, ST6GALNAC4, ST3GAL5, HEXA, ST8SIA5, ST6GALNAC6, B4GALNT1, ST6GALNAC5, ST6GALNAC3, ST8SIA1, B3GALT4, HEXB",0.47755576649368,0.155522824254319,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.27799,-0.815,0.778,10376,1,"FUT9, FUT2, FUT1, GBGT1, ST8SIA1, HEXB, GLA, NAGA",0.109020403010311,0,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.21628,-0.636,0.961,9786,1,"B3GNT2, B3GALT2, FUT9, ST3GAL6, FUT2, FUT1, ABO, B3GALT1, FUT3, ST8SIA1, B4GALT2, B3GNT4, B4GALT3, B4GAT1, B4GALT4",0.0172766123314547,0,FALSE
+"HCC44","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.53049,-1.55,0.0201,12054,0.153,"PIGB, PIGP, PIGZ, PIGN, PIGT, PIGA, PIGG, PIGK, PIGO, GPLD1, DPM2, PGAP1, PIGM, PIGF, PIGQ, PIGC, PIGV, PIGU, GPAA1",1.69680394257951,0.815308569182401,TRUE
+"HCC44","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.4592,-1.34,0.0813,12685,0.321,"AFMID, ACO1, GLYCTK, CS, GRHPR, PGP, MDH1, ACO2",1.08990945440593,0.493494967595128,FALSE
+"HCC44","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.40387,-1.18,0.201,13640,0.491,"CALML6, ATF4, MAP2K7, PRKACA, MAPK14, MAPK10, CALM1, PLCB4, GNA11, MAP3K1, ADCY6, CDC42, MAPK1, MAP3K2, MAPK9, CAMK2D, MAP3K3, MAPK7, ELK1, ADCY9, GNRH1, MAP2K6, CAMK2G, GRB2, KRAS, CALM2, PLA2G4B, SOS1, PLA2G6, MAPK11, SRC, GNAQ, PRKX, HRAS, MAPK3, PLD2, CALM3, PLA2G12A, PLCB3",0.696803942579511,0.308918507877032,FALSE
+"HCC44","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",0.6556,2.33,0,565,0.0672,"TNF, IL2, IL6, IL1B, IL1A",Inf,1.17263072694617,TRUE
+"HCC44","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.2018,-0.588,0.981,12191,1,"HHIP, WNT4, PTCH1, CSNK1G2, WNT10A, CSNK1G3, GAS1, WNT10B, BMP7, GLI1, PRKACA, BMP4, FBXW11, CSNK1G1, GSK3B, STK36, SMO, PRKX, BTRC, SUFU",0.0083309926200515,0,FALSE
+"HCC44","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.41787,1.51,0.0678,1254,0.32,"IL11, CSF3, CD38, TNF, CSF2, ITGA2, IL6, IL1B, IL1A, ITGA1, CSF1, ITGA5, IL6R, IL7R, CD55, KITLG, TFRC",1.16877030613294,0.494850021680094,FALSE
+"HCC44","Input","KEGG_HISTIDINE_METABOLISM",-0.28659,-0.834,0.751,10163,1,"AMDHD1, AOC1, MAOA, MAOB, ALDH3B2, ACY3, FTCD, ALDH7A1, LCMT2, ALDH9A1, HEMK1, LCMT1",0.124360062995832,0,FALSE
+"HCC44","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.64738,-1.91,0.00106,15780,0.0735,"BRCA2, RAD52, RPA2, MRE11, POLD3, RPA1, POLD4, RAD51C, EME1, BLM, RAD54L, MUS81, RAD51, RAD54B, SEM1",2.97469413473523,1.1337126609158,TRUE
+"HCC44","Input","KEGG_HUNTINGTONS_DISEASE",-0.57084,-1.66,0.0148,16086,0.114,"NDUFA9, NDUFS4, COX7B, POLR2E, CREB1, NDUFV2, ATP5PF, VDAC2, NDUFS5, CASP3, SLC25A4, NDUFA3, ATP5PB, POLR2J, NDUFB9, SDHD, SOD1, SDHC, COX6B1, COX7A2L, POLR2F, UQCRQ, CLTA, UQCRFS1, CREB3L4, UQCRC2, CYC1, DCTN2, SLC25A6, NDUFB7, NDUFB1, UQCR11, POLR2K, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, GNAQ, COX5A, DNAL4, NDUFA4, NDUFA10, NDUFS8, CREB3, NDUFS2, COX7C, POLR2G, NDUFV1, NDUFB8, VDAC3, NDUFB4, TP53, NDUFC2, ATP5F1C, DCTN1, POLR2L, SP1, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, PLCB3, NDUFA2, NDUFS3, SIN3A, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, COX8A, NDUFB3",1.82973828460504,0.943095148663527,TRUE
+"HCC44","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.17222,0.697,0.863,1065,0.915,"CACNA2D4, TNF, ITGA2, IL6, TGFB2, ITGA1, ITGA5, TPM4, TGFB1",0.0639892042847904,0.0385789059335517,FALSE
+"HCC44","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.47716,-1.4,0.0596,14947,0.26,"PIP4K2C, INPP5K, ITPKA, PLCG2, INPP4B, PIP4K2B, PI4KB, ITPKB, IPMK, PIK3CA, PI4KA, INPP5E, TPI1, PIKFYVE, INPPL1, INPP4A, PIK3C2B, PLCD1, PLCG1, CDIPT, PLCB3, INPP5B",1.22475374025976,0.585026652029182,FALSE
+"HCC44","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.42708,-1.25,0.142,11029,0.405,"PDE3A, RPTOR, NRAS, PRKAB2, FBP2, PRKAB1, PIK3CB, PRKCI, SLC2A4, GCK, MAP2K1, MTOR, SH2B2, AKT2, PRKAR2A, ARAF, INPP5D, PIK3R3, PPP1R3D, HK1, SHC3, SOS2, PDE3B, CBLC, FLOT2, INSR, TRIP10, FASN, SHC2, CALML6, AKT1, ACACB, TSC1, PPARGC1A, PRKACA, PIK3R1, MAPK10, CALM1, SORBS1, CBL, PPP1CC, LIPE, PHKB, PRKCZ, MAPK1, PDPK1, PRKAR1A, INPP5K, EIF4EBP1, EIF4E, PHKG2, PRKAR2B, CRKL, TSC2, MAPK9, PIK3CA, ELK1, FLOT1, GSK3B, RPS6KB1, MKNK1, RAPGEF1, PHKA2, GRB2, GYS1, KRAS, CALM2, PTPN1, IKBKB, EXOC7, SOS1, RPS6KB2, PRKX, PPP1CB, HRAS, PRKAG1, MAPK3, PIK3R2, CALM3, EIF4E2, PPP1CA, BAD",0.847711655616944,0.392544976785331,FALSE
+"HCC44","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.26305,1.03,0.393,1065,0.699,"IL2, IL6, IL15RA, MAP3K14, TGFB1",0.405607449624573,0.155522824254319,FALSE
+"HCC44","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.30773,1.11,0.383,1020,0.593,"OSM, IL24, IL11, CSF3, IL2, IFNE, CSF2, SPRY2, IL12B, IL6, MYC, IL15RA, IL13, IL6ST, SPRY4, IL20RB, SOCS4, CLCF1, SOCS3, IL6R, SPRED1, IL7R, OSMR, IFNA1",0.416801226031377,0.226945306635737,FALSE
+"HCC44","Input","KEGG_LEISHMANIA_INFECTION",0.39455,1.42,0.082,1864,0.343,"NCF2, ITGB2, PTGS2, TNF, C3, IL12B, TGFB2, IL1B, IL1A, FOS, TLR2, CYBA, TGFB1, NFKB1, IFNGR1, NFKBIA, JUN, ITGB1",1.08618614761628,0.464705879957229,FALSE
+"HCC44","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.18632,0.784,0.741,1058,0.868,"ITK, NCF2, ITGB2, ICAM1, ARHGAP5, MYL12A, CLDN1, RAC2, CYBA, VCL",0.130181792020672,0.0614802748235081,FALSE
+"HCC44","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.59875,-1.76,0.00105,15905,0.0993,"HADHA, EHHADH, ALDH9A1, ECHS1, NAA80",2.97881070093006,1.00305075150462,TRUE
+"HCC44","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.28516,-0.838,0.74,17652,1,"PLA2G4B, PLA2G6, PLA2G12A",0.130768280269024,0,FALSE
+"HCC44","Input","KEGG_LONG_TERM_DEPRESSION",-0.31732,-0.938,0.581,11495,0.963,"GNAI2, GUCY1A2, PLA2G10, MAP2K1, CACNA1A, ARAF, PRKG1, PRKCG, GUCY1A1, RYR1, GNAO1, GUCY1B1, PPP2CB, PLCB4, GNAI3, GNA11, MAPK1, PPP2R1B, GNAZ, PPP2CA, PPP2R1A, KRAS, PLA2G4B, PLA2G6, GNAQ, HRAS, MAPK3, PLA2G12A, PLCB3",0.235823867609669,0.0163737128754655,FALSE
+"HCC44","Input","KEGG_LONG_TERM_POTENTIATION",-0.40745,-1.19,0.192,13640,0.491,"CALML6, ATF4, RPS6KA6, PRKACA, RAP1A, CALM1, PLCB4, PPP1CC, RAPGEF3, CAMK4, MAPK1, PPP3CB, PPP3CC, CAMK2D, RPS6KA1, CAMK2G, KRAS, CALM2, CHP1, GNAQ, PRKX, PPP1CB, HRAS, MAPK3, CALM3, PPP1CA, PLCB3",0.71669877129645,0.308918507877032,FALSE
+"HCC44","Input","KEGG_LYSINE_DEGRADATION",-0.50729,-1.47,0.04,11803,0.204,"KMT5B, NSD1, SUV39H2, SETDB1, PIPOX, PLOD1, ALDH7A1, SETDB2, OGDH, SETD1A, ACAT2, OGDHL, AASDHPPT, KMT5A, NSD2, HADHA, EHHADH, GCDH, EHMT1, SETD1B, AADAT, KMT5C, ALDH9A1, NSD3, AASDH, ECHS1, EHMT2, SUV39H1, HADH, ACAT1",1.39794000867204,0.690369832574101,TRUE
+"HCC44","Input","KEGG_LYSOSOME",-0.38981,-1.14,0.26,13233,0.539,"SLC11A1, CLTB, AP3B2, GNPTG, ENTPD4, ACP2, PLA2G15, MCOLN1, ABCA2, GGA3, HEXB, AP1M1, ATP6V0D1, ATP6V0B, AP1S1, CLN3, GNPTAB, AP4E1, ATP6V0A1, SORT1, CLTC, AP3S1, AP1S2, AP4B1, NPC2, AP3B1, CTSA, GM2A, SCARB2, GAA, CTSH, GGA2, ATP6V1H, ATP6V0C, GLA, GGA1, AP1M2, GALNS, ARSA, SMPD1, LAPTM4A, AP3M2, CLTA, GALC, AP1B1, ASAH1, SLC17A5, AP3M1, SLC11A2, AP4M1, CTSV, AP3S2, ABCB9, NAGA",0.585026652029182,0.268411234813261,FALSE
+"HCC44","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.2661,-0.777,0.832,12927,1,"RAC3, CACNA1D, SOS2, CACNA1H, TGFB3, MAPT, PDGFRB, RASGRF2, FGF1, MAP4K1, RRAS, AKT1, ATF4, CACNB4, CACNG8, DUSP9, RASGRP2, HSPA1L, RAPGEF2, MAP2K7, RPS6KA6, PRKACA, MAPK14, RAP1A, FGF13, MAPK10, FAS, RPS6KA4, FGF12, DDIT3, CACNG4, MAP3K13, MAP3K1, FGF11, LAMTOR3, DUSP3, CDC42, PDGFB, MAPK8IP1, MAPK1, MAP3K2, RASA1, FGFR2, MAP3K6, NFATC4, MAPK8IP2, CACNA2D1, PPP3CB, FGFR4, STMN1, PPP3CC, CRKL, HSPB1, DAXX, MAPK9, MAP3K3, RPS6KA1, DUSP14, MAPK7, MAX, ARRB1, ELK1, CASP3, MAP2K6, STK4, MKNK1, PAK1, GRB2, KRAS, RELA, IKBKB, TAOK2, PLA2G4B, CHP1, CDC25B, SOS1, PLA2G6, MAP3K12, MAPK11, MAP2K5, TAOK3, PRKX, MAP3K11, ATF2, STK3, ARRB2, HRAS, TP53, MAPK3, PLA2G12A, PPM1B, TAB1, CACNB3, MAP4K2",0.0798766737092761,0,FALSE
+"HCC44","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.26932,1.02,0.348,11955,0.686,"BHLHA15, HHEX, PAX4, NEUROD1, NEUROG3, IAPP, PKLR, INS, FOXA3, HNF4G, SLC2A2, HNF4A, HNF1A, PDX1, ONECUT1, HES1, MAFA, MNX1, HNF1B, GCK, FOXA2, NR5A2",0.458420756053419,0.163675884293248,FALSE
+"HCC44","Input","KEGG_MELANOGENESIS",-0.3308,-0.98,0.501,11495,0.882,"GNAI2, WNT7A, KIT, WNT6, ADCY5, MAP2K1, FZD8, WNT4, TCF7L2, FZD3, PRKCG, CAMK2B, WNT10A, FZD7, CREBBP, GNAO1, CALML6, WNT10B, PRKACA, CALM1, PLCB4, GNAI3, FZD4, ADCY6, MAPK1, LEF1, DVL3, FZD2, CAMK2D, CREB1, GSK3B, ADCY9, TCF7L1, CAMK2G, KRAS, DVL2, CALM2, CREB3L4, GNAQ, PRKX, CREB3, HRAS, MAPK3, CALM3, PLCB3",0.300162274132754,0.0545314148681803,FALSE
+"HCC44","Input","KEGG_MELANOMA",-0.27923,-0.807,0.783,13205,1,"PDGFRB, FGF1, PDGFC, AKT1, PIK3R1, FGF13, PDGFD, FGF12, FGF11, PDGFB, MAPK1, CDK4, PIK3CA, MDM2, KRAS, E2F1, E2F2, HRAS, TP53, MAPK3, PIK3R2, BAD",0.106238237942057,0,FALSE
+"HCC44","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.1842,-0.542,0.989,18060,1,"GSTA4, ADH5, MGST3",0.0048037084028206,0,FALSE
+"HCC44","Input","KEGG_MISMATCH_REPAIR",-0.59309,-1.73,0.00316,12953,0.1,"MLH1, POLD1, MSH3, RPA3, PCNA, MSH6, EXO1, RFC4, RFC2, RPA2, POLD3, RPA1, RFC5, POLD4, PMS2, LIG1",2.5003129173816,1,TRUE
+"HCC44","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38148,-1.1,0.29,12016,0.616,"MTOR, AKT2, EIF4B, STK11, PIK3R3, PGF, AKT1, ULK3, TSC1, RPS6KA6, PIK3R1, MAPK1, PDPK1, EIF4EBP1, EIF4E, TSC2, RPS6KA1, PIK3CA, RPS6KB1, ULK1, RPS6KB2, STRADA, MLST8, MAPK3, PIK3R2, VEGFB, EIF4E2",0.537602002101044,0.210419287835575,FALSE
+"HCC44","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.21614,0.826,0.691,1373,0.846,"SH2D1B, ITGB2, KLRC2, TNF, CSF2, ICAM1, ICAM2, TNFRSF10D, TNFRSF10A, RAET1E, KLRC3, RAC2, IFNA1, ULBP2, ULBP3, IFNGR1, LAT",0.160521952625802,0.0726296369609765,FALSE
+"HCC44","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.17276,0.639,0.978,14215,0.94,"GLP2R, PTGER2, SSTR1, P2RY11, ADRA2B, P2RX5, CHRNA9, ADORA2B, GABRE, HTR7, HRH1, NR3C1, BDKRB1, CHRNA10, GHSR, S1PR3, LHB, F2RL1, BDKRB2, PRSS3, HTR2C, TRPV1, PTGER4, GCGR, GLRB, LHCGR, P2RY13, MC1R, GALR2, PLG, LTB4R, ADRB2, CALCR, GIPR, LEPR, P2RY6, AVPR2, GRIN2D, C3AR1, C5AR1, LTB4R2, LPAR2, PTGDR, P2RY14, GLRA1, GRIN1, P2RX1, TAAR2, CHRNA1, TAAR5, NPBWR2, GPR156, HTR1A, CHRNB3, HTR5A, TAAR6, LPAR1, P2RY1, TAAR8, CSH1, SSTR4, GALR1, CHRM2, HTR1D, SSTR3, FSHB, AGTR2, PRLHR, GABRA6, TAAR9, CHRNA2, MAS1, BRS3, HTR4, ADRB3, GH2, ADORA2A, RXFP2, TACR1, THRB, NTSR2, CNR2, GLRA2, F2RL3, OPRM1, GLRA3, DRD3, CHRNA3, GRM1, LEP, ADRA1A, GZMA, GRIK1, MTNR1B, HTR2B, CCKAR, NPY2R, GABRG1, TAAR1, P2RX3, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CHRND, GABRA1, PRL, FPR1, P2RY10, P2RX2, GH1, NPY4R, HCRTR1, APLNR, TSHB, HCRTR2, GABRA4, GLP1R, GPR50, GABRB2, FPR3, OPRK1, CHRM5, F2, DRD5, RXFP1, MC3R, CCKBR, FPR2, HTR1F, AVPR1A, CRHR2, S1PR4, GRM7, AVPR1B, TACR3, HRH3, ADCYAP1R1, HTR2A, GABRR2, NPY5R, GRM5, NMUR2, ADRA1D, CGA, CHRNB4, CHRNG, CYSLTR1, VIPR2, GRIA1, HTR6, UTS2R, NPFFR1, GABRA5, GRM3, GRIK3, KISS1R, P2RY8, CRHR1, NMUR1, HTR1B, CHRNA4, GRM2, PTGER3, GHRHR, CHRNA6, GABRR1, PRSS1, CHRNB2, MC5R, P2RY4, F2RL2, NPBWR1, ADORA3, MC4R, MCHR2, AGTR1, MCHR1, PRSS2, GABRB1, OXTR, GABRG3, GRIA2, TRHR, SCTR, GRIK5, P2RY2, EDNRA, EDNRB, TSHR, CHRM1, GRID2, DRD1, CTSG, PTGER1, CNR1, GRM4, GRIN3A, GRIA4, OPRD1, GRIA3, GRM8, TSPO, NTSR1, GRPR, GABRA2, GABRP, PTGIR, LPAR4, GRIN2A, GRIN2B, PTH2R, NPFFR2, HRH2, MLNR, MTNR1A, SSTR2, GPR83, SSTR5, ADRA2A, GABRG2, GNRHR, TACR2, PRLR, NPY1R, GRIK4, DRD2, ADRB1, GABRD, P2RX7, GALR3, NMBR, PTGFR, CHRM4, GABBR2, CALCRL, GRIN2C, GRID1, GRIN3B, GABRQ, PTH1R, PTAFR, GABRB3, GHR, F2R, GRIK2, P2RX6, CHRNE, GPR35, PARD3, HRH4, S1PR1, CHRNA5, TBXA2R, ADRA1B, LPAR3, DRD4, CHRM3, VIPR1, GABRA3, ADRA2C, LPAR6, OPRL1",0.00966114521239857,0.0268721464003014,FALSE
+"HCC44","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.44127,-1.32,0.102,12681,0.343,"RIPK2, PIK3R3, CAMK2B, SHC3, SOS2, BCL2, RHOA, NGFR, SHC2, CALML6, AKT1, ATF4, MAP2K7, RPS6KA6, MAGED1, PIK3R1, MAPK14, RAP1A, MAPK10, KIDINS220, CALM1, RPS6KA4, YWHAQ, SORT1, MAP3K1, CAMK4, CDC42, ARHGDIB, MAPK1, PDPK1, TP73, NFKBIE, BAX, YWHAH, PLCG2, CRKL, MAPK9, CAMK2D, MAP3K3, RPS6KA1, MAPK7, PIK3CA, SH2B1, YWHAE, GSK3B, PRDM4, GAB1, IRAK4, RAPGEF1, YWHAZ, ARHGDIA, CAMK2G, GRB2, KRAS, RELA, CALM2, IKBKB, SOS1, MAPK11, PLCG1, MAP2K5, YWHAB, HRAS, TP53, CSK, MAPK3, PIK3R2, CALM3, BAD",0.991399828238082,0.464705879957229,FALSE
+"HCC44","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.42565,1.52,0.0755,1602,0.366,"CD38, NAMPT, PNP, NT5E, NADK, NNMT, BST1, AOX1",1.12205304837081,0.436518914605589,FALSE
+"HCC44","Input","KEGG_NITROGEN_METABOLISM",-0.21551,-0.624,0.948,9246,1,"CA14, CA7, CA3, CA9, GLUD1, GLUD2, GLS2, CA13, AMT, CPS1, GLUL, CA5B",0.0231916626619338,0,FALSE
+"HCC44","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.22184,0.85,0.773,1146,0.824,"TNF, CXCL8, CXCL2, CCL5, IL6, IL1B, TNFAIP3, BIRC3, NFKB1",0.111820506081675,0.0840727883028842,FALSE
+"HCC44","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.67389,-1.96,0,14399,0.0698,"RAD50, DCLRE1C, MRE11, FEN1, XRCC6, XRCC4, XRCC5, POLL, NHEJ1",Inf,1.15614457737684,TRUE
+"HCC44","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.39943,-1.15,0.24,11127,0.529,"RB1, NRAS, EGF, FOXO3, PIK3CB, MAP2K1, AKT2, ARAF, PRKCG, PIK3R3, CASP9, SOS2, RARB, AKT1, RXRA, PIK3R1, MAPK1, PDPK1, CDK4, PLCG2, PIK3CA, STK4, GRB2, RXRB, KRAS, E2F1, E2F2, ERBB2, SOS1, PLCG1, HRAS, TP53, MAPK3, PIK3R2, BAD",0.619788758288394,0.276544327964814,FALSE
+"HCC44","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.37977,-1.11,0.277,12365,0.605,"DTX4, DLL3, ADAM17, NOTCH3, DTX1, CREBBP, DLL1, CTBP2, HDAC1, PSENEN, RBPJ, DTX2, MAML2, DVL3, KAT2B, PSEN2, DVL2, APH1A, RFNG, CTBP1, CIR1",0.557520230935551,0.218244625347531,FALSE
+"HCC44","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.56433,-1.63,0.0148,13330,0.118,"CDK7, ERCC1, POLD1, ERCC4, POLE, RAD23B, RPA3, PCNA, CETN2, RFC4, RFC2, POLE4, ERCC5, RPA2, CUL4B, XPA, POLD3, RPA1, ERCC6, RFC5, POLD4, GTF2H5, LIG1, XPC, ERCC3, DDB1, RBX1, DDB2",1.82973828460504,0.928117992693875,TRUE
+"HCC44","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.29312,-0.862,0.697,11502,1,"TUSC3, MGAT5, ALG6, MGAT5B, MGAT1, MAN1C1, ALG8, ALG1, MGAT3, DPAGT1, B4GALT2, DPM2, B4GALT3, ALG12, MAN1B1, ALG10B, RPN2, MGAT4A, ALG14, ALG10, DPM1, DPM3",0.156767221901991,0,FALSE
+"HCC44","Input","KEGG_OLFACTORY_TRANSDUCTION",0.22342,0.857,0.678,9653,0.839,"OR4F16, OR2K2, OR5B21, OR4F3, OR2B6, OR2A7, OR13H1, OR2A42, OR13A1, CNGA3, OR4F17, OR1N1, OR2A12, CNGB1, OR2A1, OR51M1, OR51I2, OR6C6, OR52J3, OR4C16, OR10AD1, OR51I1, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR51E2, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR51B4, OR2AE1, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, CALML5, OR2V2, OR56A3, OR10H2, OR52B2, OR1B1, OR2L3, OR8D1, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5M11, OR13G1, PRKACB, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR5P3, OR52N2, OR8S1, OR2AT4, OR9A2, OR51Q1, OR13D1, OR10H1, OR8D2, OR2T33, OR1J2, OR2S2, OR2A5, OR52H1, CALML3, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, OR2T8, ADCY3, OR4D1, OR2C1, OR8G1, OR4F15, OR52B6, OR2A25, OR2D3, OR1Q1, OR8A1, OR2B2, OR1K1, OR2J3, CLCA2, OR10A6, OR2A2, OR8G5, OR11H4, OR10A4, GUCY2D, OR2L2, OR6B2, OR2D2, PRKG2, OR2AG1, OR10A3, OR10A2, OR7D2, OR2A14, OR13J1",0.168770306132937,0.0762380391712997,FALSE
+"HCC44","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.53347,-1.55,0.0264,15010,0.153,"AMT, MTR, MTHFS, SHMT1, MTHFR, MTFMT, DHFR",1.57839607313017,0.815308569182401,TRUE
+"HCC44","Input","KEGG_OOCYTE_MEIOSIS",-0.53935,-1.59,0.0157,13899,0.142,"MAD2L2, CDC26, ANAPC10, RPS6KA6, PRKACA, CPEB1, PPP2CB, CALM1, YWHAQ, FBXW11, PPP1CC, ADCY6, MAPK1, CDK2, CDC20, PPP2R1B, SMC1A, PPP3CB, YWHAH, PPP3CC, ANAPC5, ANAPC7, CAMK2D, SKP1, RPS6KA1, STAG3, PPP2R5A, YWHAE, ADCY9, PTTG1, FBXO43, PPP2CA, CCNB1, PPP2R1A, YWHAZ, CAMK2G, ANAPC11, SMC3, CDC23, CALM2, SGO1, CDC27, CHP1, PLK1, PRKX, YWHAB, BUB1, CCNB2, MAD2L1, BTRC, PPP1CB, CDK1, PPP2R5B, MAPK3, ESPL1, RBX1, CALM3, PPP1CA, CDC25C, PKMYT1, PPP2R5D",1.80410034759077,0.847711655616944,TRUE
+"HCC44","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.26845,0.964,0.483,13985,0.712,"FUCA2, FUCA1, MANBA, GLB1, MAN2B1, NEU1, MAN2B2, NEU4, NEU2, HEXA, AGA, GBA, MAN2C1, NEU3, ENGASE, HEXB",0.316052869248488,0.147520006363144,FALSE
+"HCC44","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.63494,-1.85,0.0021,16086,0.0619,"NDUFA9, NDUFS4, COX7B, ATP6V1A, NDUFV2, ATP5PF, ATP6V1H, ATP6V0C, NDUFS5, NDUFA3, ATP6V1B2, ATP5PB, NDUFB9, SDHD, SDHC, COX6B1, COX7A2L, UQCRQ, UQCRFS1, ATP6V1E1, UQCRC2, ATP6V0E1, CYC1, ATP6V1E2, NDUFB7, NDUFB1, UQCR11, ATP5PD, UQCRHL, ATP5F1E, ATP6V1C1, NDUFA8, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, NDUFV1, ATP5MG, NDUFB8, NDUFB4, NDUFC2, ATP5F1C, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, ATP5ME, COX6A1, NDUFA2, ATP6V1F, NDUFS3, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, COX15, UQCRB, COX8A, NDUFB3",2.67778070526608,1.20830935097988,TRUE
+"HCC44","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.2893,1.19,0.235,1723,0.513,"GALNT14, GALNT18, GALNT5, GALNT3, GCNT4, ST3GAL1, ST3GAL2, GALNT6",0.628932137728264,0.289882634888184,FALSE
+"HCC44","Input","KEGG_P53_SIGNALING_PATHWAY",-0.45955,-1.34,0.0778,13819,0.321,"PPM1D, CHEK2, SHISA5, FAS, BBC3, CDK2, EI24, CCND3, TP73, CDK4, BAX, TSC2, SESN3, SESN1, MDM2, RRM2, CASP3, CCNB1, RCHY1, GTSE1, PIDD1, CHEK1, TP53I3, COP1, RRM2B, CCNB2, CCNG2, TP53, CDK1, DDB2, APAF1",1.10902040301031,0.493494967595128,FALSE
+"HCC44","Input","KEGG_PANCREATIC_CANCER",-0.35801,-1.04,0.377,14157,0.731,"PIK3R1, MAPK10, RALGDS, CDC42, MAPK1, BCL2L1, CDK4, MAPK9, BRCA2, PIK3CA, RALBP1, STAT1, KRAS, RELA, E2F1, IKBKB, E2F2, ERBB2, RALB, TP53, MAPK3, PIK3R2, VEGFB, RAD51, BAD",0.423658649794207,0.13608262304214,FALSE
+"HCC44","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.26331,-0.77,0.829,15876,1,"PPCS, COASY, PPCDC",0.0814454694497265,0,FALSE
+"HCC44","Input","KEGG_PARKINSONS_DISEASE",-0.62627,-1.85,0.00315,16086,0.0619,"NDUFA9, NDUFS4, COX7B, NDUFV2, ATP5PF, VDAC2, NDUFS5, CASP3, SLC25A4, NDUFA3, ATP5PB, NDUFB9, SDHD, SDHC, COX6B1, COX7A2L, UQCRQ, UQCRFS1, UQCRC2, CYC1, SLC25A6, HTRA2, NDUFB7, NDUFB1, UQCR11, UBE2L3, ATP5PD, UQCRHL, ATP5F1E, NDUFA8, COX5A, NDUFA4, NDUFA10, NDUFS8, NDUFS2, COX7C, UBA1, NDUFV1, NDUFB8, VDAC3, NDUFB4, NDUFC2, ATP5F1C, NDUFAB1, UQCR10, NDUFA6, NDUFS1, NDUFB6, COX6A1, NDUFA2, NDUFS3, APAF1, NDUFB10, COX5B, COX6C, NDUFC1, NDUFA1, ATP5MC3, UQCRB, COX8A, NDUFB3",2.5016894462104,1.20830935097988,TRUE
+"HCC44","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.32696,-0.954,0.539,13176,0.934,"TLR5, RHOA, TLR4, TUBB4A, CTTN, TUBA1A, YWHAQ, ARPC4, TUBB2B, CDC42, TUBB4B, TUBB, TUBA1B, YWHAZ, ARPC5, ARPC2, NCK2, ARPC3",0.268411234813261,0.0296531237699066,FALSE
+"HCC44","Input","KEGG_PATHWAYS_IN_CANCER",-0.24669,-0.727,0.898,12842,1,"WNT10A, TFG, CASP9, RAC3, MLH1, FZD7, SOS2, BCL2, TGFB3, SKP2, CBLC, PDGFRB, CREBBP, RHOA, FGF1, PGF, RARB, CSF2RA, AXIN2, AKT1, CKS1B, WNT10B, DAPK2, RXRA, CCDC6, GLI1, CTBP2, MSH3, ITGA2B, PIK3R1, APPL1, HDAC1, PTK2, FGF13, MAPK10, BMP4, FAS, RALGDS, CBL, FGF12, MSH6, TRAF5, FGF11, FZD4, BCR, CDC42, PDGFB, LAMA4, MAPK1, BCL2L1, CDK2, FGFR2, LEF1, CDK4, BAX, DVL3, APC, FN1, DAPK1, PLCG2, CRKL, FZD2, MAPK9, GSTP1, BRCA2, NCOA4, FH, MAX, PIK3CA, RALBP1, GSK3B, AXIN1, MDM2, CASP3, STAT1, STK36, TPM3, TCF7L1, STK4, PIAS3, CDKN1B, ELOC, FADD, GRB2, RXRB, KRAS, BIRC5, DVL2, RELA, E2F1, SMO, IKBKB, PIAS1, E2F2, PML, ERBB2, SOS1, EGLN2, PLCG1, RALB, ARNT, CTBP1, SUFU, HRAS, TP53, MAPK3, PIK3R2, RBX1, VEGFB, ELOB, RAD51, BAD",0.0467236633326956,0,FALSE
+"HCC44","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.39454,-1.16,0.22,14856,0.512,"XYLB, RPEL1, RPE, UGP2, DCXR",0.657577319177794,0.290730039024169,FALSE
+"HCC44","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.33773,-0.992,0.47,14924,0.853,"GPI, DERA, RPEL1, PRPS2, PFKL, ALDOA, RPE",0.327902142064283,0.069050968832477,FALSE
+"HCC44","Input","KEGG_PEROXISOME",-0.56653,-1.66,0.0139,14879,0.114,"FAR2, AGPS, ACAA1, IDH2, SLC25A17, ACSL3, GNPAT, PEX1, DECR2, EHHADH, PEX16, NUDT12, CAT, ABCD4, AMACR, PEX14, PAOX, SOD1, HMGCL, PEX6, CROT, FAR1, IDH1, PMVK, MPV17, PHYH, ACOX1, PEX26, ACSL1, PXMP4, PECR, PEX13, PEX19, ACOT8, PEX11A, PEX2, PEX11B, MVK, PRDX5",1.8569851997459,0.943095148663527,TRUE
+"HCC44","Input","KEGG_PHENYLALANINE_METABOLISM",-0.30137,-0.87,0.694,18020,1,"GOT1, NAA80",0.158640529545145,0,FALSE
+"HCC44","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.40758,-1.18,0.211,12578,0.491,"CDS1, INPP5D, PRKCG, PIK3R3, PLCD4, PIK3C2A, PIK3C3, IMPA2, CALML6, PIP5K1A, PIK3R1, CALM1, PLCB4, PIP4K2C, INPP5K, ITPKA, PLCG2, DGKZ, INPP4B, PIP4K2B, PI4KB, ITPKB, PIK3CA, PI4KA, INPP5E, DGKQ, CALM2, DGKA, PIKFYVE, INPPL1, INPP4A, PIK3C2B, PLCD1, PLCG1, CDS2, PIK3R2, CALM3, CDIPT, PLCB3, INPP5B",0.675717544702307,0.308918507877032,FALSE
+"HCC44","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.4969,-1.46,0.0439,13076,0.204,"BLVRB, UROS, HCCS, EARS2, BLVRA, CPOX, ALAS1, HMBS, HMOX2, MMAB, PPOX, ALAD, COX15",1.35753547975788,0.690369832574101,TRUE
+"HCC44","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.28413,-0.824,0.766,13748,1,"SCP2, RXRA, ACADM, SORBS1, NR1H3, CPT1C, PDPK1, ACAA1, ACSL3, EHHADH, UBC, SCD5, RXRB, SLC27A4, CPT1B, ILK, ACOX1, SLC27A1, ACSL1, DBI",0.115771230367396,0,FALSE
+"HCC44","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.30544,-0.892,0.649,11696,1,"CYP7B1, CYP46A1, CYP27A1, HSD17B4, SCP2, AMACR",0.187755303199631,0,FALSE
+"HCC44","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.20933,-0.609,0.967,8705,1,"CD79A, PTPRC, CD3D, LCK, ZAP70, BTK, IGLL1, CD19, CD8A, RFXAP, BLNK, JAK3, CD4, TNFRSF13C, RAG1, DCLRE1C, ADA, RFXANK, RFX5, UNG",0.0145735259169983,0,FALSE
+"HCC44","Input","KEGG_PRION_DISEASES",0.24129,0.946,0.49,1251,0.724,"CCL5, IL6, IL1B, IL1A, HSPA5, HSPA1A, EGR1",0.309803919971486,0.140261433802853,FALSE
+"HCC44","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.46708,-1.36,0.082,13899,0.302,"MAD2L2, CDC26, ANAPC10, RPS6KA6, PRKACA, PIK3R1, MAPK14, CPEB1, MAPK10, GNAI3, ADCY6, MAPK1, CDK2, ANAPC5, ANAPC7, MAPK9, RPS6KA1, PIK3CA, ADCY9, CCNB1, KRAS, ANAPC11, FZR1, CDC23, CDC27, CDC25B, MAPK11, PLK1, CCNA2, PRKX, BUB1, CCNB2, MAD2L1, CDK1, MAPK3, PIK3R2, CDC25C, PKMYT1",1.08618614761628,0.519993057042849,FALSE
+"HCC44","Input","KEGG_PROPANOATE_METABOLISM",-0.56638,-1.64,0.0179,13553,0.116,"ALDH7A1, ACACB, ACADM, ACAT2, SUCLA2, LDHA, ABAT, HADHA, EHHADH, ALDH9A1, ACSS1, ECHS1, MCEE, ACSS2, SUCLG1, ACAT1, HIBCH",1.74714696902011,0.935542010773082,TRUE
+"HCC44","Input","KEGG_PROSTATE_CANCER",-0.3657,-1.07,0.347,12908,0.668,"CASP9, SOS2, BCL2, PDGFRB, CREBBP, PDGFC, AKT1, ATF4, PIK3R1, PDGFD, PDGFB, MAPK1, CDK2, FGFR2, PDPK1, LEF1, GSTP1, PIK3CA, CREB1, GSK3B, MDM2, TCF7L1, CDKN1B, GRB2, KRAS, RELA, E2F1, CREB3L4, IKBKB, E2F2, ERBB2, SOS1, CREB3, HRAS, TP53, MAPK3, PIK3R2, BAD",0.459670525209126,0.175223537524454,FALSE
+"HCC44","Input","KEGG_PROTEASOME",-0.4455,-1.29,0.105,11249,0.362,"PSMD7, PSMD2, PSMD3, PSMC5, PSMB7, PSMA5, PSMB1, PSMD6, PSMF1, PSMB10, PSMB2, PSMA1, PSMB5, PSMA2, PSMB4, PSMC2, PSMB3, PSMA4, PSMD1, PSMD4, PSMD13, PSMB6, PSMD14, PSMC3, SEM1",0.978810700930062,0.441291429466834,FALSE
+"HCC44","Input","KEGG_PROTEIN_EXPORT",-0.39777,-1.16,0.233,14823,0.512,"SPCS1, SRP68, SEC61A2, SEC11A, SPCS2, SRP9, IMMP1L, SRP14",0.632644078973981,0.290730039024169,FALSE
+"HCC44","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.23545,-0.688,0.91,17617,1,"SLC25A10, MDH1",0.0409586076789064,0,FALSE
+"HCC44","Input","KEGG_PURINE_METABOLISM",-0.28405,-0.836,0.76,11825,1,"ADCY5, POLR2C, PDE6B, POLR1B, ITPA, NME1, POLR2A, ADCY10, PDE4C, NUDT5, ENTPD2, AK5, PDE1C, ENTPD8, NME5, PDE8B, POLR3B, GUCY1A1, PDE3B, POLR3GL, NT5C, ENTPD4, POLD1, PDE5A, POLA1, POLR2D, POLE, ENTPD6, PRUNE1, GUCY1B1, POLR2H, NT5M, ADCY6, DCK, RRM1, NPR2, POLE4, PRPS2, ADA, GMPR, POLR2I, PDE9A, POLR2E, POLR3K, ADCY9, RRM2, DGUOK, POLR2J, POLD3, AK1, NME6, PKM, GUK1, POLR2F, POLD4, RRM2B, PRIM2, POLR2K, NUDT2, NUDT9, POLR2G, POLR2L, POLA2, PAPSS1, PDE6D",0.119186407719209,0,FALSE
+"HCC44","Input","KEGG_PYRIMIDINE_METABOLISM",-0.36115,-1.06,0.362,13319,0.68,"POLR3GL, NT5C, ENTPD4, POLD1, POLA1, POLR2D, POLE, ENTPD6, POLR2H, NT5M, TXNRD2, DCK, RRM1, POLE4, POLR2I, POLR2E, POLR3K, RRM2, POLR2J, POLD3, NME6, POLR2F, POLD4, RRM2B, PRIM2, POLR2K, NUDT2, DUT, CTPS2, POLR2G, UPRT, UCK1, DTYMK, POLR2L, POLA2, TK1",0.441291429466834,0.167491087293764,FALSE
+"HCC44","Input","KEGG_PYRUVATE_METABOLISM",-0.45442,-1.32,0.0979,13327,0.343,"HAGHL, ALDH7A1, ACACB, DLAT, ACAT2, LDHA, GLO1, GRHPR, ALDH9A1, ACYP2, ACSS1, PKM, PDHB, ACSS2, MDH1, HAGH, PDHA1, ACAT1",1.00921730819686,0.464705879957229,FALSE
+"HCC44","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.29494,-0.862,0.73,13205,1,"PDGFRB, RHOA, FGD3, FGF1, MYLPF, PDGFC, RRAS, IQGAP2, CHRM3, ITGA4, IQGAP1, PIP5K1A, ITGAE, ITGB6, ITGA2B, TIAM2, PIK3R1, MYL5, PTK2, FGF13, PDGFD, ARPC4, FGF12, PPP1CC, FGF11, PAK4, CDC42, PDGFB, MAPK1, PIP4K2C, MYH14, VAV3, FGFR2, PAK6, ITGA7, APC, FGFR4, FN1, CRKL, SSH2, PFN1, PIP4K2B, NCKAP1, ITGB8, PIK3CA, WASF2, IQGAP3, BRK1, SSH3, FGD1, PAK1, ARPC5, KRAS, CYFIP2, LIMK2, CYFIP1, ARPC2, PIKFYVE, SOS1, ABI2, GSN, CFL1, GIT1, PPP1CB, HRAS, CSK, MAPK3, PIK3R2, ARPC3, PPP1CA",0.136677139879544,0,FALSE
+"HCC44","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.3692,-1.08,0.312,11925,0.647,"ATG5, GABARAPL2, PIK3R4, PIK3C3, GABARAPL1, ATG12, ULK3, BECN1, ATG4C, ATG4D, ATG3, GABARAP, ULK1, ATG4B",0.505845405981557,0.1890957193313,FALSE
+"HCC44","Input","KEGG_RENAL_CELL_CARCINOMA",-0.40483,-1.19,0.19,11880,0.491,"MAP2K1, CUL2, AKT2, ARNT2, ARAF, PTPN11, PIK3R3, SOS2, TGFB3, CREBBP, PGF, AKT1, PIK3R1, RAP1A, FLCN, PAK4, CDC42, PDGFB, MAPK1, PAK6, CRKL, FH, PIK3CA, GAB1, RAPGEF1, PAK1, ELOC, GRB2, KRAS, SOS1, EGLN2, ARNT, HRAS, MAPK3, PIK3R2, RBX1, VEGFB, ELOB",0.721246399047171,0.308918507877032,FALSE
+"HCC44","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.24293,-0.71,0.906,7767,1,"CPA3, MME, AGTR1, CMA1, CTSG, ACE2, NLN, LNPEP, THOP1, CTSA",0.0428718023231869,0,FALSE
+"HCC44","Input","KEGG_RETINOL_METABOLISM",-0.21094,-0.626,0.954,17948,1,"RETSAT, ADH5, DGAT1",0.0204516252959049,0,FALSE
+"HCC44","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.26854,-0.787,0.836,8605,1,"ACP5, ENPP1, ENPP3, ACP4, MTMR2, ACP2, ACP1, PHPT1, MTMR6",0.0777937225609836,0,FALSE
+"HCC44","Input","KEGG_RIBOSOME",-0.26248,-0.764,0.868,15502,1,"RPL8, RPL37A, RPLP2, RPL41, RPL38, RPS2, RPL30, RPS27L, RPS4X, RPS26, MRPL13, RPLP1, FAU",0.0614802748235081,0,FALSE
+"HCC44","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.20584,-0.606,0.968,14164,1,"PIN1, MAPK14, MAPK10, MAP3K1, NLRX1, SIKE1, TBKBP1, MAPK9, TRADD, TANK, FADD, RELA, MAVS, IKBKB, MAPK11, OTUD5, TKFC",0.0141246426916063,0,FALSE
+"HCC44","Input","KEGG_RNA_DEGRADATION",-0.52036,-1.52,0.0279,15192,0.172,"PAPOLG, XRN1, LSM8, CNOT7, DCP2, MTREX, LSM6, CNOT9, ZCCHC7, ENO3, EDC3, C1D, EXOSC3, LSM1, CNOT6, DDX6, LSM2, WDR61, EXOSC4, LSM3, CNOT6L, LSM4, EXOSC1, PARN, CNOT8",1.5543957967264,0.764471553092451,TRUE
+"HCC44","Input","KEGG_RNA_POLYMERASE",-0.44571,-1.31,0.118,11507,0.355,"POLR3D, POLR2C, POLR1B, POLR2A, POLR3B, POLR3GL, POLR2D, POLR2H, POLR2I, POLR2E, POLR3K, POLR2J, POLR2F, POLR2K, POLR2G, POLR2L",0.928117992693875,0.449771646944906,FALSE
+"HCC44","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.37925,-1.1,0.285,17182,0.616,"HEMK1, SEPHS2, MAT2B, PAPSS1, LCMT1",0.54515513999149,0.210419287835575,FALSE
+"HCC44","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.22876,0.875,0.574,1952,0.83,"PTGS2, COL4A6, FHIT, TRAF1, ITGA2, LAMC2, MYC, CDKN2B, LAMB3, E2F3, TRAF3, COL4A2, COL4A1, BIRC3, NFKB1, LAMB1, LAMA5, NFKBIA, IKBKG, LAMA3, ITGAV, ITGB1, ITGA3",0.241088107602027,0.0809219076239261,FALSE
+"HCC44","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.40795,-1.2,0.175,13791,0.509,"VTI1B, VAMP2, STX12, STX3, STX2, VAMP4, BNIP1, STX18, STX17, STX6, STX5, SNAP47, STX4, STX10, TSNARE1, SNAP29, STX7, SNAP23",0.756961951313706,0.293282217663241,FALSE
+"HCC44","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.27985,-0.827,0.763,13121,1,"NEU3, CERK, PLPP1, SMPD3, ACER2, SGPL1, ACER3, GLA, ARSA, SMPD1, GALC, SMPD4, ASAH1, SPHK2",0.11747546204512,0,FALSE
+"HCC44","Input","KEGG_SPLICEOSOME",-0.50857,-1.52,0.0389,13455,0.172,"HNRNPM, SF3A3, SNRNP40, LSM5, LSM7, MAGOH, HSPA1L, PRPF31, PRPF18, U2AF1, DDX23, PHF5A, SMNDC1, AQR, CRNKL1, DHX8, PRPF8, HNRNPK, SNRPB2, PRPF19, HNRNPU, PPIE, SF3B4, SNRPD2, SNRPF, LSM8, SF3B6, SNRNP200, PLRG1, SNRPE, SRSF3, LSM6, SF3A1, RBM17, PRPF38A, SNRPD1, SNRNP27, SF3B1, PRPF40A, WBP11, LSM2, CCDC12, SNRPC, USP39, PPIH, SNRPA, SYF2, SART1, SLU7, SNRPG, SF3B2, LSM3, CWC15, PRPF40B, SRSF9, LSM4, ZMAT2, XAB2, PUF60, PQBP1, PCBP1, CTNNBL1, THOC3, HNRNPA3, SNRPD3",1.41005039867429,0.764471553092451,TRUE
+"HCC44","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.21969,-0.646,0.937,8696,1,"PYGB, PYGM, ENPP1, AMY2B, ENPP3, AGL, MGAM, HK3, TREH, UGT2B7, GCK, PGM1, PGM2, HK1, PGM2L1, GPI, UXS1, GAA, GYS1, UGP2, GANC",0.0282604091122217,0,FALSE
+"HCC44","Input","KEGG_STEROID_BIOSYNTHESIS",-0.63231,-1.82,0.00209,15389,0.0676,"TM7SF2, EBP, NSDHL, SQLE, LSS, MSMO1, FDFT1, SC5D, HSD17B7",2.67985371388895,1.17005330405836,TRUE
+"HCC44","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.19263,0.734,0.811,1142,0.892,"SRD5A2, CYP1B1, HSD11B2, AKR1C3, AKR1C1",0.090979145788844,0.0496351456238769,FALSE
+"HCC44","Input","KEGG_SULFUR_METABOLISM",-0.67475,-1.98,0,17252,0.115,"CHST12, BPNT1, SULT1A3, SUOX, PAPSS1",Inf,0.939302159646388,TRUE
+"HCC44","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.17888,-0.518,0.994,16160,1,"SSB, TRIM21, SNRPD1, SNRPD3",0.00261361560268669,0,FALSE
+"HCC44","Input","KEGG_TASTE_TRANSDUCTION",0.33855,1.2,0.261,1532,0.53,"TAS2R46, TAS2R14, TAS2R43, TAS2R9, TAS1R3, TAS2R4, ITPR3, TAS2R13, TAS2R10, TAS2R5",0.583359492661719,0.275724130399211,FALSE
+"HCC44","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.35056,1.37,0.14,12415,0.373,"GGT1, GAD1, GAD2, BAAT, GGT5, GGT7, ADO, GGT6, CDO1, CSAD",0.853871964321762,0.428291168191312,FALSE
+"HCC44","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.63339,-1.86,0.00214,13801,0.0851,"HMGCR, GGPS1, ACAT2, PDSS2, MVD, HMGCS1, IDI1, PMVK, ACAT1, MVK",2.66958622665081,1.07007043991541,TRUE
+"HCC44","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.26954,-0.781,0.845,12104,1,"ACVR1C, DCN, ID1, THBS2, ZFYVE16, SMAD9, CHRD, TGFB3, RBL2, CREBBP, RHOA, ID4, ACVR2A, RBL1, BMP7, ID2, THBS4, BMPR1A, BMP4, PPP2CB, SMAD6, MAPK1, PPP2R1B, ACVR1, SKP1, ZFYVE9, THBS3, ACVR2B, PPP2CA, SMAD5, RPS6KB1, PPP2R1A, BMPR2, RPS6KB2, MAPK3, RBX1, SP1",0.0731432910503077,0,FALSE
+"HCC44","Input","KEGG_THYROID_CANCER",-0.42694,-1.24,0.133,13926,0.42,"RXRA, CCDC6, MAPK1, LEF1, NCOA4, TPM3, TCF7L1, RXRB, KRAS, HRAS, TP53, MAPK3",0.876148359032914,0.3767507096021,FALSE
+"HCC44","Input","KEGG_TIGHT_JUNCTION",-0.30876,-0.911,0.625,11065,0.981,"MYL9, NRAS, ACTN2, CLDN9, MAGI2, PRKCI, CRB3, PATJ, GNAI2, MAP3K20, IGSF5, JAM2, PRKCD, AKT2, CSNK2A1, PRKCG, PARD3, CLDN22, EPB41L3, RHOA, PPP2R2B, EPB41, MYLPF, TJP3, RRAS, PRKCQ, CTTN, AKT1, MYH11, CLDN3, JAM3, MYL5, PPP2CB, LLGL1, PARD6G, SPTAN1, GNAI3, PRKCZ, PPP2R2D, CDC42, MYH14, CASK, PPP2R1B, CDK4, MAGI3, LLGL2, TJAP1, PARD6B, PARD6A, PPP2CA, PPP2R2A, CGN, PPP2R1A, KRAS, MPDZ, EPB41L1, SRC, HRAS",0.204119982655925,0.0083309926200515,FALSE
+"HCC44","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.18443,-0.544,0.989,13969,1,"SPP1, MAP2K7, PIK3R1, MAPK14, MAPK10, MAPK1, TICAM1, IRF5, MAPK9, IFNAR1, TLR3, PIK3CA, STAT1, MAP2K6, IRAK4, FADD, RELA, IKBKB, MAPK11, TOLLIP, MAPK3, PIK3R2, TAB1",0.0048037084028206,0,FALSE
+"HCC44","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.30515,-0.893,0.654,14333,1,"OGDH, ACAT2, OGDHL, HADHA, EHHADH, GCDH, CAT, AADAT, ALDH9A1, ECHS1, HADH, ACAT1",0.184422251675733,0,FALSE
+"HCC44","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.2847,-0.836,0.736,9549,1,"PIK3R5, PIK3CD, HK3, CACNA1B, PDX1, MAPK8, CACNA1C, MAFA, PIK3CB, CACNA1G, SLC2A4, GCK, MTOR, PRKCD, CACNA1A, PIK3R3, HK1, CACNA1D, INSR, KCNJ11, PIK3R1, MAPK10, PRKCZ, MAPK1, MAPK9, PIK3CA, PKM, IKBKB, MAPK3, PIK3R2",0.133122185662501,0,FALSE
+"HCC44","Input","KEGG_TYPE_I_DIABETES_MELLITUS",0.59358,2.32,0,1735,0.0336,"TNF, IL2, IL12B, IL1B, IL1A, GAD1, CPE, ICA1",Inf,1.47366072261016,TRUE
+"HCC44","Input","KEGG_TYROSINE_METABOLISM",-0.32666,-0.959,0.52,17182,0.929,"HEMK1, GOT1, NAA80, ADH5, LCMT1",0.283996656365201,0.0319842860063582,FALSE
+"HCC44","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26296,-0.773,0.843,13042,1,"SOS2, CBLC, RHOA, PRKCQ, AKT1, NFATC3, MAP2K7, PIK3R1, MAPK14, CBL, PAK4, CDC42, MAPK1, VAV3, PDPK1, PAK6, NFATC4, CDK4, NFKBIE, PPP3CB, PPP3CC, MAPK9, PIK3CA, GSK3B, PAK1, GRB2, KRAS, RELA, IKBKB, CHP1, SOS1, NCK2, MAPK11, PLCG1, HRAS, MAPK3, PIK3R2",0.0741724253752577,0,FALSE
+"HCC44","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.49681,-1.46,0.0541,13127,0.204,"ITCH, SKP2, CBLC, UBE2B, ANAPC1, UBE2D3, PRKN, FANCL, TRIP12, UBE2Q2, CDC26, ANAPC10, UBE2D2, UBE2N, UBE2Q1, KLHL9, CBL, FBXW11, PRPF19, WWP1, MAP3K1, UBE2Z, MID1, UBE2K, CDC20, SAE1, ANAPC5, UBE2G1, RNF7, ANAPC7, UBE2D1, SKP1, KLHL13, UBE2F, HUWE1, CUL4B, UBE2W, UBA6, HERC3, MDM2, FBXO4, UBR5, PIAS3, CDC34, UBE4B, ELOC, CUL3, ANAPC11, MGRN1, HERC2, FZR1, RCHY1, CDC23, RHOBTB2, UBA3, BRCA1, UBE3B, PIAS1, PPIL2, CDC27, PML, COP1, UBE2L3, STUB1, UBOX5, UBE2I, DDB1, UBE2R2, UBA1, BTRC, CUL7, UBE2C, HERC1, RBX1, ELOB, DDB2",1.26680273489343,0.690369832574101,FALSE
+"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.59423,-1.74,0.00624,17102,0.104,"PDHB, IARS2, PDHA1",2.20481541031758,0.98296666070122,TRUE
+"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.5125,-1.51,0.0375,12913,0.177,"IVD, BCKDHB, ALDH7A1, DBT, ACADM, ACAT2, ACAA1, ABAT, HADHA, EHHADH, HMGCL, ALDH9A1, HMGCS1, AUH, ECHS1, ACADS, MCEE, ACADSB, HADHB, HSD17B10, HADH, ACAT1, HIBCH",1.42596873227228,0.752026733638193,TRUE
+"HCC44","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.31717,-0.939,0.571,11672,0.971,"GUCY1A2, ACTG2, PLA2G10, ADCY5, MAP2K1, PRKCD, ARAF, ARHGEF12, PRKG1, PRKCG, GUCY1A1, CACNA1D, RHOA, RAMP2, PRKCQ, CALML6, ADRA1B, MYH11, KCNMA1, KCNMB4, PRKACA, MYL6B, GUCY1B1, CALM1, PLCB4, PPP1CC, GNA11, KCNMB3, ADCY6, MAPK1, NPR2, ACTA2, ARHGEF11, ADCY9, PPP1R12B, MYL6, CALM2, PLA2G4B, PLA2G6, GNAQ, PRKX, PPP1CB, MAPK3, CALM3, PLA2G12A, PPP1CA, PLCB3",0.243363891754152,0.0127807700919951,FALSE
+"HCC44","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.55176,-1.61,0.0158,13038,0.129,"DCTN4, DCTN6, RAB5A, VAMP2, DYNLL2, PRKACA, DYNC1I1, ADCY6, ARHGDIB, RAB5C, CREB1, ADCY9, RAB11B, DCTN5, ARHGDIA, STX4, CREB3L4, DYNLL1, DCTN2, DYNC2LI1, PRKX, CREB3, DCTN1, DYNC1I2, RAB5B, RAB11A",1.80134291304558,0.889410289700751,TRUE
+"HCC44","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32871,-0.96,0.54,13572,0.937,"SHC2, AKT1, NFATC3, PIK3R1, MAPK14, PTK2, NOS3, CDC42, MAPK1, NFATC4, PPP3CB, PPP3CC, PLCG2, HSPB1, PIK3CA, KRAS, PLA2G4B, CHP1, PLA2G6, MAPK11, SRC, PLCG1, SPHK2, HRAS, MAPK3, PIK3R2, PLA2G12A, BAD",0.267606240177031,0.0282604091122217,FALSE
+"HCC44","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.47245,-1.38,0.0673,14098,0.277,"PRKACA, ATP6V0D1, ARF1, ATP6V0B, ATP6V1G1, ATP6V0A1, ATP6V1G2, ATP6V1B1, ATP6V0E2, PLCG2, ATP6V1A, ATP6V1H, ATP6V0C, ADCY9, SEC61A2, ATP6V1B2, ATP6V1E1, ATP6V0E1, ATP6V1E2, PLCG1, ATP6V1C1, PRKX, ATP6V1F",1.17198493577602,0.557520230935551,FALSE
+"HCC44","Input","KEGG_VIRAL_MYOCARDITIS",0.24298,0.899,0.549,2365,0.807,"ITGB2, ICAM1, RAC2, CD55, ABL2, EIF4G1, CD40, EIF4G3, MYH9, CYCS",0.260427655549908,0.0931264652779296,FALSE
+"HCC44","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.32111,-0.937,0.589,10108,0.956,"PPP3R2, PPP3CA, DAAM1, WNT11, WNT2B, PRKCA, CAMK2A, LRP5, PPARD, NKD1, MAPK8, ROCK1, PLCB2, PRICKLE2, FZD5, WNT9A, APC2, CSNK1A1, SIAH1, PPP2R5C, LRP6, WNT7A, CXXC4, WNT6, PPP2R5E, FZD8, WNT4, VANGL2, TCF7L2, CCND2, FZD3, CSNK2A1, FRAT2, DAAM2, PRKCG, CAMK2B, WNT10A, RAC3, FZD7, CREBBP, RHOA, SFRP1, AXIN2, WNT10B, NFATC3, CTBP2, PRKACA, MAPK10, PPP2CB, PLCB4, FBXW11, FZD4, CCND3, LEF1, PPP2R1B, TBL1XR1, NFATC4, DVL3, PPP3CB, APC, PPP3CC, FZD2, MAPK9, CAMK2D, SKP1, PPP2R5A, FRAT1, GSK3B, AXIN1, PPP2CA, TCF7L1, PPP2R1A, CAMK2G, DVL2, CACYBP, CHP1, PRKX, CTNNBIP1, BTRC, CTBP1, TP53, PPP2R5B, RBX1, PLCB3, PPP2R5D",0.229884705212898,0.0195421077238999,FALSE
+"A549","Input","KEGG_ABC_TRANSPORTERS",0.2741,0.973,0.471,1809,0.662,"ABCG2, ABCC2, ABCC1, ABCC4, ABCC3, ABCD3, ABCB10",0.326979092871104,0.1791420105603,FALSE
+"A549","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.36552,-1.3,0.142,16954,0.76,"BRAF, LEF1, PIK3CA, AKT1, RUNX1, PIK3R3, MAPK3, MTOR, PPARD, PML, PIK3R2",0.847711655616944,0.119186407719209,FALSE
+"A549","Input","KEGG_ADHERENS_JUNCTION",0.2964,1.08,0.307,2211,0.546,"PARD3, ACP1, SRC, TGFBR1, TJP1, PTPRJ, IGF1R, ACTG1, ACTN4, PTPRM, VCL, SMAD3, RHOA, SNAI1, SMAD2, NECTIN3, MET, CSNK2A1, FGFR1",0.512861624522813,0.262807357295263,FALSE
+"A549","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.20579,0.731,0.83,3746,0.899,"PRKCQ, TRAF2, TNFRSF1A, STAT3, AKT2, CHUK, ACSL3, NFKBIB, ADIPOR2, AKT3, PTPN11, PRKAA2, CAMKK1, CPT1C, ACACB, MAPK9, MAPK8",0.0809219076239261,0.0462403082667712,FALSE
+"A549","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.30172,-1.09,0.321,16316,0.654,"GLS2, ABAT, GLUL, GPT, ASS1, IL4I1, ASL, GAD1, GPT2",0.493494967595128,0.184422251675733,FALSE
+"A549","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.27822,-0.997,0.413,15843,0.707,"NR3C2, PIK3R1, INSR, PIK3CA, ATP1A1, PIK3R3, MAPK3, PIK3R2",0.384049948343599,0.150580586203101,FALSE
+"A549","Input","KEGG_ALLOGRAFT_REJECTION",0.58561,2.1,0.00445,6,0.0918,"IL5",2.35163998901907,1.03715731879876,TRUE
+"A549","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.31057,-1.12,0.261,17771,0.725,"PLA2G12A, PLA2G6, PLA2G4B",0.583359492661719,0.139661993429006,FALSE
+"A549","Input","KEGG_ALZHEIMERS_DISEASE",0.19008,0.689,0.9,2930,0.925,"GRIN2B, ATP2A2, UQCRFS1, CALM2, TNFRSF1A, PSENEN, COX6B1, IDE, PLCB4, CHP1, NAE1, ATP5F1B, ATP5MC1, PPP3R1, CAPN2, NDUFB10, ADAM17, ATP5F1C, CASP8, GRIN2D, PSEN2, PPP3CA, APAF1, PSEN1, NDUFA9, ADAM10, ATP5MC3, GAPDH, FAS",0.0457574905606751,0.0338582672609674,FALSE
+"A549","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.40949,1.49,0.0641,1993,0.326,"EARS2, MTFMT, IARS2, YARS2, FARSB, DARS2, NARS2, SARS2",1.19314197048118,0.486782399932061,FALSE
+"A549","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.30292,-1.09,0.301,15267,0.654,"GMPPB, GNPDA1, RENBP, PMM1, GALE, GMPPA, CYB5R1, GALT, UAP1, PGM2, NPL, CYB5R3, GMDS, AMDHD2, HK2",0.521433504406157,0.184422251675733,FALSE
+"A549","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.31316,1.13,0.273,3073,0.541,"GRIN2B, TNFRSF1A, TOMM40, CHP1, PPP3R1, MAP2K6, GRIN2D, PPP3CA, APAF1, DERL1, BCL2L1, CYCS",0.563837352959244,0.266802734893431,FALSE
+"A549","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.22718,0.814,0.719,1332,0.813,"IFNA13, HSPA2, PSME3, CTSL, HSPA4, HSP90AA1",0.143271109617117,0.0899094544059319,FALSE
+"A549","Input","KEGG_APOPTOSIS",0.34892,1.28,0.157,3073,0.439,"MAP3K14, TRAF2, TNFRSF1A, AIFM1, CFLAR, IL1R1, AKT2, TNFRSF10D, CHP1, BIRC3, PRKX, PPP3R1, TNFRSF10A, CHUK, TNFRSF10B, CAPN2, IRAK2, CASP8, AKT3, PPP3CA, APAF1, EXOG, FAS, BCL2L1, TNFRSF10C, CYCS",0.804100347590766,0.357535479757879,FALSE
+"A549","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.26509,0.949,0.472,885,0.668,"AKR1C3, GPX2, GGT1, CYP4F3, LTA4H, PLA2G4A",0.326058001365912,0.175223537524454,FALSE
+"A549","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.29593,1.1,0.281,793,0.538,"P4HA3, AGMAT, ALDH3A2, AMD1, GLS, ALDH1B1, GOT2",0.55129368009492,0.269217724333611,FALSE
+"A549","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.36983,1.33,0.131,1975,0.442,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, ITGA11, GJA1, ACTG1, ACTN4, ITGB5, SGCA, CDH2, CACNG8",0.882728704344236,0.354577730650908,FALSE
+"A549","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.63856,2.32,0,739,0.0861,"UGDH, ALDH3A2, ALDH1B1",Inf,1.06499684854635,TRUE
+"A549","Input","KEGG_ASTHMA",0.61896,2.25,0,6,0.0625,"IL5",Inf,1.20411998265592,TRUE
+"A549","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.56491,2.05,0.00228,29,0.0873,"IL5, IFNA13",2.64206515299955,1.05898575629443,TRUE
+"A549","Input","KEGG_AXON_GUIDANCE",-0.34891,-1.27,0.156,14908,0.796,"RAC3, EPHB1, UNC5A, NFATC1, CXCR4, PLXNC1, NTNG1, SEMA6D, SEMA3F, ABLIM2, EFNB3, SRGAP3, SEMA3D, SEMA6C, EPHB6, EPHA4, EFNA4, PLXNB2, SEMA6A, ARHGEF12, NTN1, EFNA3, SEMA5A, SEMA7A, SLIT2, NCK2, PLXNA2, EFNB1, SEMA3B, UNC5B, LIMK1, SEMA4A, ROBO3, PLXNB3, PAK6, EPHA1, PAK2, PLXNA1, EPHB3, MAPK3, NFATC4, SEMA4C, RAC2, PLXNB1, EFNB2, FYN, SRGAP2, LIMK2, GNAI2, PLXNA3",0.806875401645538,0.0990869322623309,FALSE
+"A549","Input","KEGG_BASAL_CELL_CARCINOMA",-0.31089,-1.12,0.284,15378,0.725,"AXIN2, FZD7, AXIN1, DVL2, WNT10A, DVL1, PTCH1, WNT2B, SUFU, STK36, BMP2, LEF1, WNT5A, FZD4, FZD1, GLI3, DVL3",0.546681659952962,0.139661993429006,FALSE
+"A549","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.39787,-1.45,0.072,16587,0.797,"STON1, TAF1, TAF13, GTF2B, TAF4, GTF2H2, TAF11, TAF12, TAF6L, GTF2H4, GTF2IRD1",1.14266750356873,0.0985416786038876,FALSE
+"A549","Input","KEGG_BASE_EXCISION_REPAIR",0.34063,1.24,0.167,3558,0.457,"NEIL3, TDG, UNG, PCNA, POLE4, LIG3, POLE2, APEX2, POLD4, NEIL2, POLE3, APEX1",0.777283528852417,0.34008379993015,FALSE
+"A549","Input","KEGG_BETA_ALANINE_METABOLISM",0.3133,1.14,0.262,3467,0.534,"ALDH3A2, ALDH1B1, HADHA, HIBCH, ALDH2, ECHS1",0.581698708680255,0.272458742971444,FALSE
+"A549","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.64676,2.36,0.00217,2949,0.135,"BAAT, ELOVL2, HACD2, HACD1, FADS2, ACOT1, PECR, HADHA, ACOT2, FADS1, YOD1, HSD17B12",2.66354026615147,0.869666231504994,TRUE
+"A549","Input","KEGG_BLADDER_CANCER",-0.31765,-1.15,0.238,16340,0.783,"RPS6KA5, MMP1, E2F2, BRAF, RASSF1, MAPK3, CDKN2A, VEGFA, VEGFB",0.623423042943488,0.106238237942057,FALSE
+"A549","Input","KEGG_BUTANOATE_METABOLISM",0.24206,0.881,0.588,2903,0.716,"AKR1B10, ALDH3A2, ALDH1B1, HADHA, ACSM3, ALDH2, HMGCS1",0.230622673923862,0.145086977692144,FALSE
+"A549","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26891,-0.951,0.466,14885,0.74,"BLNK, RAC3, VAV2, CD72, NFATC1, JUN, CD22, DAPP1, PIK3R1, BCL10, SYK, PIK3CA, AKT1, PIK3R3, MAPK3, IFITM1, NFATC4, RAC2, FOS, PIK3R2",0.33161408331,0.130768280269024,FALSE
+"A549","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2841,1.04,0.374,3051,0.56,"CD38, ATP2A2, CACNA1G, BST1, PHKA1, PLCE1, VDAC1, CALM2, VDAC2, ATP2B1, VDAC3, ADRA1B, GNAL, PLCB4, CHP1, TRPC1, PDE1A, PDE1C, PRKX, PPP3R1, CACNA1H, AGTR1, PLCD3, HRH2, P2RX5, PRKCA, PPID, OXTR, PHKB, GRIN2D, PPP3CA, CAMK2D, HTR2B, SLC25A5, RYR1, ADRA1D",0.42712839779952,0.2518119729938,FALSE
+"A549","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.28927,1.07,0.315,1190,0.548,"ATP2A2, UQCRFS1, CACNG7, FXYD2, CACNA2D1, CACNG6, COX6B1, TPM1, TPM2, ATP1B1",0.501689446210399,0.261219441515631,FALSE
+"A549","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.2094,0.755,0.82,2687,0.893,"CNTN1, NRCAM, ITGAV, ESAM, ITGAM, CDH4, ITGB1, PVR, PTPRM, CDH2, MPZL1, NEO1, NECTIN3, CLDN1, CLDN2, CADM1, CLDN23, SDC1",0.0861861476162833,0.0491485411114536,FALSE
+"A549","Input","KEGG_CELL_CYCLE",0.24874,0.883,0.578,3925,0.72,"YWHAQ, CCND3, ORC4, ORC2, TGFB2, CDC27, ORC5, SMAD3, PCNA, ANAPC5, SMC3, CUL1, MCM6, SMAD2, RBL1, CCNE1, CCNB1, CCNB3, SFN, YWHAG, CDKN1A, CCNB2, SKP1, CDC23, CDC6, PRKDC, CDC26, ORC1, BUB1, PLK1, ANAPC7, SMAD4, STAG2, ANAPC1, CDK1, YWHAB, CDK7, GADD45B, ANAPC11, E2F5, SMC1A, YWHAZ, TTK",0.238072161579471,0.142667503568732,FALSE
+"A549","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.18309,-0.678,0.935,14653,0.933,"ADCY4, GNGT1, XCL1, GNB1, VAV2, JAK3, GRK7, BCAR1, CCL5, CXCR4, PRKCD, GNG13, PLCB2, SHC4, PLCB1, SHC3, GNB2, CCL27, GNG7, GNB3, CX3CL1, PIK3R1, RAP1A, PLCB3, SHC2, CCR10, CCL28, BRAF, PIK3CA, AKT1, PRKACA, CRKL, PIK3R3, TIAM2, MAPK3, GRK6, RAC2, GRK4, TIAM1, GRK2, STAT2, GNAI2, FOXO3, PIK3R2",0.0291883891274822,0.0301183562535,FALSE
+"A549","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.33335,-1.21,0.181,15325,0.833,"SHC4, GAB2, SHC3, CBLC, CBL, PIK3R1, HDAC1, SHC2, E2F2, TGFB3, BRAF, PIK3CA, AKT1, CDKN1B, CRKL, RUNX1, PIK3R3, MAPK3, CDKN2A, MECOM, CTBP1, BCR, PIK3R2",0.742321425130815,0.0793549985932124,FALSE
+"A549","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.54545,-1.94,0.00726,15631,0.372,"CLOCK, CSNK1D, PER1, BHLHE41, CRY2, PER3, NR1D1, CSNK1E",2.13906337929991,0.429457060118102,FALSE
+"A549","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29894,1.08,0.279,4429,0.546,"ACLY, IDH3A, DLD, PC, SUCLG1, MDH1, IDH1, IDH3B, SUCLA2, SDHC, ACO1, CS",0.554395796726402,0.262807357295263,FALSE
+"A549","Input","KEGG_COLORECTAL_CANCER",-0.26368,-0.951,0.469,14908,0.74,"RAC3, MAPK10, JUN, AXIN2, AXIN1, PIK3R1, BCL2, TGFB3, BRAF, LEF1, PIK3CA, AKT1, PIK3R3, MAPK3, RAC2, RALGDS, FOS, PIK3R2",0.328827157284917,0.130768280269024,FALSE
+"A549","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.46565,1.66,0.0226,2571,0.256,"FGA, C5, FGB, FGG, PLG, F2, SERPINE1, PROC, C1S, C4BPA, C4BPB, THBD, F13B, CD59, C5AR1, CFH",1.6458915608526,0.59176003468815,FALSE
+"A549","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.30639,1.11,0.283,2736,0.559,"AMD1, GOT2, LDHA, TRDMT1, LDHB, DNMT3B, ADI1, MAT2A, SDS",0.54821356447571,0.252588192113577,FALSE
+"A549","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20573,0.737,0.816,3249,0.908,"IL5, IFNA13, CXCL5, BMPR1B, EDA2R, IL15, TNFRSF1A, TGFBR1, CCL2, CCR7, TGFB2, IL18, CCL26, BMPR1A, IL1R1, TNFRSF10D, IL11, IL13RA1, INHBB, TNFRSF10A, IFNE, CLCF1, TNFRSF10B, PF4, MET, TNFRSF9, FLT4, AMHR2, IL18R1, BMPR2, VEGFD, IL6ST, CSF2RA, TNFSF12, TGFBR2, IFNAR2, TNFSF15, FAS, TNFRSF10C, IL22RA1, TNFSF9, OSMR, EGFR",0.0883098412461389,0.0419141514789149,FALSE
+"A549","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26521,0.949,0.487,2989,0.668,"IFNA13, TBK1, IL18, CHUK, PYCARD, NFKBIB, POLR3K, POLR3G, POLR3F, POLR3D",0.312471038785366,0.175223537524454,FALSE
+"A549","Input","KEGG_DILATED_CARDIOMYOPATHY",0.3531,1.29,0.153,1975,0.436,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, TGFB2, TPM1, ITGA11, TPM2, ACTG1, PRKX, ITGB5, SGCA, TPM4, CACNG8",0.815308569182401,0.360513510731414,FALSE
+"A549","Input","KEGG_DNA_REPLICATION",0.43957,1.62,0.0442,4206,0.266,"PRIM1, RNASEH1, RFC5, PCNA, RPA1, POLE4, MCM6, POLE2, POLA1, POLD4, DNA2, RNASEH2B, RFC3, SSBP1, POLE3, FEN1, MCM4",1.35457773065091,0.575118363368933,FALSE
+"A549","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.30842,-1.11,0.277,15132,0.682,"SPIRE1, NOTCH2, PIWIL4, NOTCH1, ETV7, NOTCH4, MAPK3",0.557520230935551,0.166215625343521,FALSE
+"A549","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.12039,0.435,1,1539,1,"ALDH3A1, MGST1, ALDH3B1",0,0,FALSE
+"A549","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.27049,0.992,0.416,2345,0.63,"CES1, UMPS, CDA, UCK2, GMPS, CES5A, HPRT1",0.380906669373257,0.200659450546418,FALSE
+"A549","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.20132,0.73,0.867,961,0.892,"VTN, COL4A4, ITGAV, COL5A2, SPP1, ITGB1, COL4A6, ITGA11",0.0619809025237897,0.0496351456238769,FALSE
+"A549","Input","KEGG_ENDOCYTOSIS",-0.20255,-0.716,0.866,14554,0.895,"CSF1R, EPS15, KIT, SH3GL3, EHD4, ARFGAP3, IQSEC1, GRK7, CXCR4, CHMP4B, FGFR3, LDLR, ACAP2, ADRB2, EPN3, ARFGAP1, AGAP2, CBLC, PARD6A, CBL, ASAP3, VPS28, RAB11FIP4, RAB11FIP3, HGS, LDLRAP1, RAB5B, AP2A1, FGFR2, SH3GLB2, AP2M1, VPS4A, RAB22A, PSD, RAB11B, ARAP2, VPS37C, ARAP1, GRK6, SH3GL1, VPS37B, MVB12A, SMAP2, GRK4, ACAP3, GRK2, PIP5K1C, DNM2, ARFGAP2",0.0624821079826534,0.048176964684088,FALSE
+"A549","Input","KEGG_ENDOMETRIAL_CANCER",-0.34472,-1.25,0.17,15378,0.806,"AXIN2, AXIN1, ELK1, PIK3R1, BRAF, LEF1, PIK3CA, AKT1, PIK3R3, MAPK3, FOXO3, PIK3R2",0.769551078621726,0.0936649581949093,FALSE
+"A549","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23325,0.847,0.644,3746,0.761,"ATP6V1E2, MAP3K14, MAP2K4, SRC, TJP1, CHUK, ATP6V0E1, MET, ADAM17, PTPN11, LYN, ADAM10, EGFR, ATP6V0E2, ATP6V1C1, MAPK9, MAPK8",0.191114132640188,0.118615343229427,FALSE
+"A549","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.26041,-0.935,0.516,14851,0.723,"HBEGF, CAMK2B, MAPK10, JUN, RPS6KB2, SHC4, SHC3, CBLC, ELK1, CBL, PIK3R1, SHC2, BRAF, PIK3CA, AKT1, NCK2, GAB1, CDKN1B, CRKL, PAK6, PAK2, PLCG1, PIK3R3, MAPK3, MTOR, MAP2K7, PIK3R2",0.287350298372789,0.140861702705469,FALSE
+"A549","Input","KEGG_ETHER_LIPID_METABOLISM",0.25985,0.95,0.49,3570,0.693,"CHPT1, PLA2G4A, PAFAH1B1, PLPP1, PAFAH1B3, AGPS, PLPP2, LPCAT2",0.309803919971486,0.159266765388193,FALSE
+"A549","Input","KEGG_FATTY_ACID_METABOLISM",-0.20678,-0.744,0.824,16436,0.897,"ACADVL, ECI1, ACSL5, HADH, GCDH, CPT2",0.0840727883028842,0.0472075569559079,FALSE
+"A549","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.25351,-0.908,0.534,14908,0.758,"RAC3, VAV2, MAPK10, PRKCD, GAB2, MAPK12, PIK3R1, SYK, MAPK14, PIK3CA, AKT1, PLA2G12A, LAT, PLCG1, PIK3R3, PLA2G6, MAPK3, PLA2G4B, RAC2, MAPK13, FYN, MAP2K7, PIK3R2",0.272458742971444,0.120330794367946,FALSE
+"A549","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.29224,-1.06,0.347,17036,0.624,"MARCKS, PIK3CA, ARPC5L, AKT1, LIMK1, CRKL, LAT, PLCG1, PIK3R3, WASF3, PLA2G6, MAPK3, PLA2G4B, RAC2, PIP5K1C, LIMK2, DNM2, WASF2, PIK3R2",0.459670525209126,0.204815410317576,FALSE
+"A549","Input","KEGG_FOCAL_ADHESION",0.23857,0.865,0.566,4730,0.733,"PDGFD, VTN, ROCK2, FLNB, COL4A4, CCND3, ITGAV, COL5A2, SRC, CRK, SPP1, ITGB1, COL4A6, PPP1CC, VAV1, ARHGAP5, ITGA11, AKT2, BIRC3, IGF1R, ACTG1, ACTN4, ITGB5, VCL, CAV1, RHOA, CAPN2, CAV2, RAP1B, PRKCA, HRAS, MET, COL4A1, FLT4, AKT3, COL5A1, ACTB, VEGFD, PPP1R12A, COL4A2, LAMC2, EGFR, COL11A1, PPP1CB, SOS1, PTK2, MAP2K1, ILK, ACTN1, VAV3, FLNA, MAPK9, MAPK8, PXN, ITGB6, LAMC1, DOCK1, ITGA2B, SOS2, FN1, ROCK1, ITGA5, LAMC3, LAMB1, LAMB4, ZYX, VEGFC, LAMA5, ITGA3, PARVA, MYL2, CTNNB1, ARHGAP35, PIK3CB",0.247183568811729,0.134896025358872,FALSE
+"A549","Input","KEGG_FOLATE_BIOSYNTHESIS",0.29043,1.07,0.355,179,0.548,"SPR",0.449771646944906,0.261219441515631,FALSE
+"A549","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.29031,1.05,0.322,1301,0.551,"AKR1B10, PFKFB3, AKR1B1, PMM2, PFKP",0.492144128304169,0.258848401148215,FALSE
+"A549","Input","KEGG_GALACTOSE_METABOLISM",0.29664,1.09,0.299,1897,0.546,"GLA, AKR1B1, B4GALT1, UGP2, PFKP, MGAM, GALK1",0.52432881167557,0.262807357295263,FALSE
+"A549","Input","KEGG_GAP_JUNCTION",0.25132,0.929,0.486,4331,0.683,"PDGFD, TUBA4A, SRC, TJP1, PLCB4, GJA1, PRKX, MAP3K2, TUBAL3, PRKCA, HRAS, TUBA1C, TUBA1B, HTR2B, PRKG2, LPAR1, EGFR, SOS1, CDK1, TUBB4A, MAP2K1, TUBB4B, GNAI1, DRD1, TUBB3, KRAS, SOS2, TUBA1A, ADRB1",0.313363730737707,0.165579296318467,FALSE
+"A549","Input","KEGG_GLIOMA",-0.28577,-1.02,0.383,15006,0.699,"CAMK2B, SHC4, SHC3, PDGFRB, CALML6, PIK3R1, SHC2, E2F2, BRAF, PIK3CA, AKT1, PLCG1, PIK3R3, MAPK3, CDKN2A, MTOR, PIK3R2",0.416801226031377,0.155522824254319,FALSE
+"A549","Input","KEGG_GLUTATHIONE_METABOLISM",0.4543,1.66,0.031,2898,0.256,"PGD, G6PD, GPX2, GSR, GCLM, GCLC, GGT1, MGST1, RRM2B, IDH1, RRM1, MGST2, GPX3",1.50863830616573,0.59176003468815,FALSE
+"A549","Input","KEGG_GLYCEROLIPID_METABOLISM",0.34439,1.26,0.153,3410,0.447,"GLA, LCLAT1, DGKG, AKR1B1, ALDH3A2, ALDH1B1, DGKD, GPAT3, AGK, PLPP1, ALDH2, GPAT4, MBOAT2, PLPP2, MGLL",0.815308569182401,0.349692476868064,FALSE
+"A549","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.2477,0.906,0.544,2061,0.706,"LCLAT1, CDS2, DGKG, CHPT1, CRLS1, PLA2G4A, DGKD, LPGAT1, GPAT3, GPD1L, ETNK1, GNPAT, PTDSS1, PLPP1",0.26440110030182,0.151195298948196,FALSE
+"A549","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.25122,-0.897,0.562,15637,0.769,"SARDH, GNMT, DMGDH, CTH, SHMT2, AMT, GCAT",0.250263684430939,0.114073660198569,FALSE
+"A549","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.32423,1.2,0.189,2953,0.461,"ALDH3A1, ENO3, GPI, ALDH3A2, ALDH1B1, LDHA, GALM, PFKP, ALDH3B1, DLD, LDHB, TPI1, PKM, ALDH2, PGAM1, GAPDH, ENO1",0.723538195826756,0.336299074610352,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.30104,-1.07,0.328,15581,0.665,"B3GAT3, CHSY3, CHST14, B3GALT6, CHST12, B4GALT7, UST, CHPF",0.484126156288321,0.177178354696895,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.50018,-1.8,0.0233,12935,0.492,"EXTL1, HS6ST3, EXTL2, HS3ST5, NDST3, HS3ST3B1, EXTL3, B3GAT1, EXT1, HS3ST1, XYLT2, B3GAT3, B3GALT6, HS3ST3A1, HS6ST2, HS6ST1, B4GALT7, NDST2",1.63264407897398,0.30803489723264,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.2953,-1.06,0.346,15219,0.624,"CHST6, B4GAT1, CHST2, B4GALT2, B4GALT3, ST3GAL3",0.460923901207223,0.204815410317576,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.47606,-1.71,0.0197,16275,0.547,"HS3ST3A1, SGSH, HYAL2, IDUA, GUSB",1.70553377383841,0.262012673666569,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.34925,-1.24,0.183,13218,0.79,"ST6GALNAC4, ST8SIA5, ST3GAL1, HEXB, SLC33A1, ST6GALNAC6, ST6GALNAC5, B3GALT4",0.737548910269571,0.102372908709559,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.36646,-1.3,0.159,13444,0.76,"FUT9, ST3GAL1, HEXB, B3GALT5, FUT2, FUT1, B3GALNT1, NAGA",0.798602875679548,0.119186407719209,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.31284,-1.1,0.282,13041,0.667,"FUT7, FUT9, ABO, FUT4, ST3GAL4, B3GALT1, B3GALT5, ST3GAL6, B4GAT1, FUT2, FUT3, FUT1, B4GALT2, B3GNT4, B4GALT3, ST3GAL3",0.549750891680639,0.175874166083451,FALSE
+"A549","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.29279,1.05,0.331,4601,0.551,"PIGB, PIGO, PIGF, PIGW, PIGA, PIGN, PIGH, GPLD1, PIGU, PIGC, PIGL, PIGX",0.480172006224281,0.258848401148215,FALSE
+"A549","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.30715,1.1,0.276,4623,0.538,"MDH1, MTHFD2, AFMID, MTHFD1, PGP, ACO1, CS, MTHFD2L",0.559090917934782,0.269217724333611,FALSE
+"A549","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.27279,-0.984,0.438,14653,0.708,"ADCY4, HBEGF, CACNA1C, CAMK2B, MAPK10, JUN, PRKCD, PLCB2, PLCB1, CALML6, MAPK12, ELK1, GNAS, ITPR3, MAP3K3, PLCB3, MAPK14, LHB, GNA11, PRKACA, MAP3K1, PLA2G12A, ATF4, MAP3K4, PLA2G6, MAPK3, PLA2G4B, MAPK13, MMP14, MAP2K7",0.3585258894959,0.149966742310231,FALSE
+"A549","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.2782,-1.01,0.381,8202,0.707,"KIR2DL1, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, KLRC1, CD86, GZMB, TNF, IL1A, IL6, IL1B",0.419075024324381,0.150580586203101,FALSE
+"A549","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.25644,-0.933,0.519,15926,0.715,"CSNK1D, WNT10A, GAS1, BMP7, PTCH1, WNT2B, SUFU, STK36, BMP2, WNT5A, PRKACA, GLI3, CSNK1G2, CSNK1E",0.284832642151542,0.145693958198919,FALSE
+"A549","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.25929,0.943,0.498,1152,0.663,"IL5, CD38, ITGAM, IL1R1, IL11",0.302770657240282,0.178486471595227,FALSE
+"A549","Input","KEGG_HISTIDINE_METABOLISM",0.4112,1.49,0.0549,2752,0.326,"ALDH3A1, AMDHD1, ALDH3A2, ALDH1B1, ALDH3B1, METTL6, METTL2B, BUD23, ALDH2",1.26042765554991,0.486782399932061,FALSE
+"A549","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.33074,1.2,0.219,3298,0.461,"RAD50, RAD51C, NBN, RPA1, RAD54B, BLM, POLD4, RAD51D, SSBP1",0.659555885159882,0.336299074610352,FALSE
+"A549","Input","KEGG_HUNTINGTONS_DISEASE",-0.2219,-0.792,0.723,14500,0.856,"TBP, NDUFA1, HDAC2, BBC3, GRIN1, NDUFS8, HTT, DNAH2, ATP5PB, PLCB2, DNALI1, PLCB1, NDUFA2, NDUFV3, UQCRB, NDUFA5, CREB3L1, SDHD, COX8A, COX7C, POLR2J, CREB3L2, UQCR10, SP1, EP300, HDAC1, ATP5PO, PLCB3, PPARGC1A, AP2A1, NDUFA3, DNAH1, NDUFA6, AP2M1, POLR2F, NDUFS6, TAF4, CREBBP, CREB3L4, NDUFC1, UQCRHL, CREB5, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, NDUFS7, DNAL4, NDUFV1, POLR2H, COX5B",0.140861702705469,0.0675262353228468,FALSE
+"A549","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.35307,1.25,0.174,1975,0.452,"ATP2A2, SGCD, CACNG7, ITGAV, CACNA2D1, CACNG6, ITGB1, TGFB2, TPM1, ITGA11, TPM2, ACTG1, ITGB5, SGCA, TPM4, CACNG8",0.7594507517174,0.344861565188618,FALSE
+"A549","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.32577,-1.16,0.242,15324,0.787,"PLCB2, PLCB1, INPP5J, PLCB3, ITPKB, PIK3CA, INPP5B, ITPKA, PI4KB, SYNJ1, PLCG1, INPPL1, INPP5E, PI4KA, ALDH6A1, PIP5K1C",0.616184634019569,0.104025267640935,FALSE
+"A549","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.26916,-0.95,0.462,15123,0.729,"MAPK10, GYS1, FASN, PYGM, RPS6KB2, SHC4, SHC3, PHKG1, PHKA2, CALML6, CBLC, ELK1, CBL, PIK3R1, MKNK1, PPP1R3D, SHC2, PPARGC1A, INSR, BRAF, PIK3CA, AKT1, FLOT1, TSC1, SORBS1, MKNK2, PRKACA, CRKL, SOCS1, SH2B2, PIK3R3, PTPN1, MAPK3, MTOR, TSC2, PIK3R2, HK2",0.335358024443874,0.137272471682025,FALSE
+"A549","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.38221,1.39,0.111,445,0.405,"IL5, MAP3K14, IL15",0.954677021213343,0.392544976785331,FALSE
+"A549","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.20203,0.736,0.855,3248,0.9,"IL5, STAT4, IFNA13, CCND3, SOCS5, JAK1, IL15, STAT3, AKT2, IL11, IL13RA1, IFNE, CLCF1, STAT1, AKT3, PTPN11, IL6ST, CSF2RA, PIAS1, IFNAR2, BCL2L1, STAM, SOCS4, STAM2, IL22RA1, OSMR",0.0680338852718274,0.0457574905606751,FALSE
+"A549","Input","KEGG_LEISHMANIA_INFECTION",-0.24077,-0.869,0.624,13721,0.806,"TNF, MAPK11, MARCKSL1, TAB2, IL1A, ITGA4, FCGR2A, JUN, IFNGR2, IL1B, MAPK12, ELK1, TLR4, TLR2, MAPK14, ITGB2, TGFB3, MAPK3, MAPK13, TAB1, FOS",0.204815410317576,0.0936649581949093,FALSE
+"A549","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.20889,-0.742,0.843,14723,0.888,"ITGA4, SIPA1, JAM2, VAV2, BCAR1, CLDN20, CXCR4, CLDN11, CLDN22, CLDN9, CLDN4, RAPGEF4, MAPK12, MYLPF, PIK3R1, RAP1A, RASSF5, TXK, MAPK14, ITGB2, RAPGEF3, PIK3CA, CLDN7, ICAM1, AFDN, PLCG1, PIK3R3, RAC2, MAPK13, MYL5, GNAI2, PIK3R2",0.0741724253752577,0.051587034221399,FALSE
+"A549","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.56669,2.08,0.00654,3467,0.0865,"ALDH3A2, ALDH1B1, HADHA, ALDH2, YOD1, ECHS1",2.18442225167573,1.06298389253519,TRUE
+"A549","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.24918,0.912,0.509,885,0.702,"AKR1B10, PLA2G4A",0.293282217663241,0.153662887870195,FALSE
+"A549","Input","KEGG_LONG_TERM_DEPRESSION",-0.19783,-0.723,0.851,14941,0.895,"GUCY1B1, PRKG1, PLCB2, PLCB1, GUCY1A1, GNAS, ITPR3, GNAO1, PLCB3, BRAF, GNA11, PLA2G12A, PLA2G6, MAPK3, PLA2G4B, GNAI2",0.0700704399154121,0.048176964684088,FALSE
+"A549","Input","KEGG_LONG_TERM_POTENTIATION",0.31951,1.11,0.272,2778,0.559,"GRIN2B, CALM2, RPS6KA3, RPS6KA6, PPP1CC, PLCB4, CHP1, PRKX, PPP3R1, RAP1B, PRKCA, HRAS, GRIN2D, PPP3CA, CAMK2D, PPP1R12A",0.565431095965801,0.252588192113577,FALSE
+"A549","Input","KEGG_LYSINE_DEGRADATION",-0.36247,-1.3,0.129,17133,0.76,"KMT5C, OGDHL, KMT5B, SETDB2, PLOD3, OGDH, SETD1B, HADH, DOT1L, AASS, EHMT2, GCDH",0.889410289700751,0.119186407719209,FALSE
+"A549","Input","KEGG_LYSOSOME",-0.3232,-1.14,0.235,16365,0.751,"CD164, AP3B2, MANBA, ACP5, ABCB9, TPP1, LAMP3, PPT1, AP4M1, SORT1, MCOLN1, CTSA, NEU1, SGSH, SMPD1, AP3D1, MAN2B1, ATP6V0B, CTSO, ARSG, LAMP1, ATP6V0C, IGF2R, IDUA, AP1B1, PPT2, GUSB, NAGA, GGA1, GNPTG",0.628932137728264,0.124360062995832,FALSE
+"A549","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.1989,0.725,0.897,2968,0.882,"CACNA1G, MAP3K14, FLNB, CACNG7, TRAF2, HSPA2, MAP2K4, RPS6KA3, PPM1B, TNFRSF1A, CACNA2D1, CACNG6, TGFBR1, CRK, MAP3K8, TGFB2, FGF2, RPS6KA6, PLA2G4A, IL1R1, ARRB2, AKT2, CHP1, DUSP1, PRKX, BDNF, PPP3R1, CHUK, MAP3K20, CACNA1H, MAP3K2, MAP2K6, NFKB2, RAP1B, CACNG8, PRKCA, TAOK1, HRAS, FGFR1, FGFR4, DUSP5, AKT3, HSPA8, PPP3CA, NF1, PPM1A, GNG12, HSPA1A, TGFBR2, CACNG4, FAS, RASGRP4, RRAS",0.0472075569559079,0.0545314148681803,FALSE
+"A549","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.62782,2.24,0.00435,1038,0.0533,"NR5A2, HNF4A, FOXA2, HNF1A, HNF1B, HHEX",2.36151074304536,1.27327279097343,TRUE
+"A549","Input","KEGG_MELANOGENESIS",-0.2357,-0.85,0.677,14514,0.822,"WNT6, KIT, ADCY4, CAMK2B, PLCB2, PLCB1, FZD7, CREB3L1, DVL2, CALML6, MC1R, WNT10A, GNAS, CREB3L2, DVL1, EP300, GNAO1, PLCB3, WNT2B, LEF1, WNT5A, FZD4, PRKACA, CREBBP, CREB3L4, FZD1, MAPK3, GNAI2, DVL3",0.169411331314856,0.0851281824599496,FALSE
+"A549","Input","KEGG_MELANOMA",-0.23597,-0.83,0.704,15856,0.827,"PDGFRB, FGF22, PDGFC, PIK3R1, FGF12, E2F2, FGF13, BRAF, PIK3CA, AKT1, FGF11, PIK3R3, MAPK3, CDKN2A, PIK3R2",0.152427340857888,0.0824944904474534,FALSE
+"A549","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.40668,1.47,0.0775,1756,0.336,"AKR1C2, AKR1C3, ALDH3A1, AKR1C1, MGST1, CYP2S1, ALDH3B1, AKR1C4, EPHX1",1.11069829749369,0.473660722610156,FALSE
+"A549","Input","KEGG_MISMATCH_REPAIR",0.62679,2.26,0.00216,3298,0.0807,"MSH6, MLH3, RFC5, PCNA, RPA1, EXO1, MSH2, MSH3, POLD4, MLH1, RFC3, SSBP1",2.66554624884907,1.09312646527793,TRUE
+"A549","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.35255,-1.3,0.137,15990,0.76,"MLST8, PIK3R1, STK11, BRAF, PIK3CA, AKT1, TSC1, PIK3R3, MAPK3, MTOR, VEGFA, TSC2, RPS6KA2, VEGFB, PIK3R2",0.863279432843593,0.119186407719209,FALSE
+"A549","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.19789,-0.726,0.869,14362,0.903,"KLRK1, ULBP2, ULBP3, RAET1L, RAC3, VAV2, NFATC1, SHC4, SHC3, IFNGR2, ICAM2, PIK3R1, SYK, SHC2, HCST, ITGB2, BRAF, PIK3CA, TNFSF10, ICAM1, IFNAR1, LAT, PLCG1, PIK3R3, MAPK3, NFATC4, RAC2, FYN, SH3BP2, PIK3R2",0.0609802235513335,0.0443122496864942,FALSE
+"A549","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.25888,0.946,0.516,427,0.665,"NPY4R, GABRA5, GRIN2B, GLP2R, GABRB3, CHRNA5, HTR1D, PARD3, F2RL2, S1PR3, PLG, P2RY6",0.287350298372789,0.177178354696895,FALSE
+"A549","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.29635,-1.06,0.339,15006,0.624,"CAMK2B, MAPK10, RPS6KA1, JUN, PRKCD, SHC4, SHC3, CALML6, MAPK12, NGFR, MAPKAPK2, PIK3R1, RAP1A, RPS6KA5, MAP3K3, ARHGDIB, SHC2, MAPK14, BCL2, CAMK4, SORT1, BRAF, PIK3CA, AKT1, GAB1, CRKL, MAP3K1, ATF4, TP73, PLCG1, SH2B2, PIK3R3, MAPK3, SH2B1, SH2B3, MAPK13, RPS6KA2, MAP2K7, FOXO3, PIK3R2",0.469800301796918,0.204815410317576,FALSE
+"A549","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38506,1.38,0.105,3284,0.405,"CD38, BST1, NAMPT, NT5C2, NNMT, PNP, AOX1, NT5C",0.978810700930062,0.392544976785331,FALSE
+"A549","Input","KEGG_NITROGEN_METABOLISM",0.28161,1.06,0.35,3214,0.558,"CA12, CA8, GLS, GLUD2, CPS1, GLUD1",0.455931955649724,0.253365801062421,FALSE
+"A549","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.22647,-0.805,0.703,12898,0.867,"MAP3K7, IKBKB, CXCL8, XIAP, MEFV, TRIP6, TNF, MAPK11, PSTPIP1, TAB2, NOD2, TAB3, NLRP3, MAPK10, CCL5, TNFAIP3, IL6, IL1B, MAPK12, CARD9, NLRP1, NAIP, MAPK14, CASP1, MAPK3, MAPK13, TAB1",0.153044674980176,0.0619809025237897,FALSE
+"A549","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.38921,1.4,0.0984,2998,0.406,"RAD50, NHEJ1, XRCC5, XRCC4, PRKDC",1.00700490156866,0.391473966422806,FALSE
+"A549","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.40776,-1.48,0.0735,16138,0.813,"PIK3R1, RASSF5, E2F2, BRAF, PIK3CA, RASSF1, AKT1, PLCG1, FHIT, PIK3R3, MAPK3, CDKN2A, FOXO3, RXRB, PIK3R2",1.1337126609158,0.0899094544059319,FALSE
+"A549","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.39712,-1.41,0.101,16295,0.831,"DVL1, EP300, HDAC1, DLL1, NOTCH1, DTX3L, RBPJ, MAML2, NOTCH4, CREBBP, HES1, MAML1, RFNG, CTBP1, NCSTN, APH1A, DVL3",0.995678626217357,0.080398976215889,FALSE
+"A549","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.34276,1.26,0.153,3591,0.447,"DDB2, RFC5, PCNA, CETN2, ERCC8, RPA1, POLE4, ERCC1, ERCC4, POLE2, GTF2H1, POLD4, RFC3, MNAT1, ERCC3, CDK7, POLE3, XPC",0.815308569182401,0.349692476868064,FALSE
+"A549","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.26796,-0.946,0.472,12011,0.712,"ALG6, DPM1, ST6GAL1, MGAT5, STT3A, RPN2, ALG14, MAN2A2, DPM3, MGAT4B, MAN1A2, MGAT3, ALG3, ALG11, RPN1, GANAB, ALG12, DPM2, MAN1C1, MAN1B1, MGAT2, DDOST, B4GALT2, MOGS, MAN1A1, B4GALT3, MGAT1",0.326058001365912,0.147520006363144,FALSE
+"A549","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.21007,-0.761,0.812,6799,0.89,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR9Q2, OR6C68, OR6C74, OR10C1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, CNGA3, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, CLCA1, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR4C6, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, OR51E2, GUCA1C, OR2M4, OR7A5, OR8B8, OR9G1, CAMK2A, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR2V2, OR56A3, OR10H2, OR52B2, OR51M1, OR1B1, OR2L3, OR8D1, OR11H6, PDC, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, CNGA4, OR3A2, OR5P2, OR5B21, OR5M11, OR13G1, OR2L13, OR5K1, OR1M1, OR51B2, OR52D1, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, OR13D1, OR8D2, OR2T33, OR2S2, OR2A5, OR52H1, CALML3, OR52A1, OR1C1, OR1F1, OR14I1, OR5C1, OR1J4, OR2B11, CALML5, OR2T8, OR2C1, OR8G1, OR4F15, OR52B6, OR51B4, OR2A25, OR2D3, CAMK2G, OR10H1, OR8A1, OR1K1, OR2J3, OR10A6, OR2A2, OR8G5, OR4F3, OR11H4, OR10A4, GUCY2D, OR13A1, OR2A12, OR2D2, OR2H2, OR2AG1, OR10A3, OR2K2, OR7C1, OR10A2, OR7D2, OR2A14, OR13J1, OR4F16, CLCA2, OR2B6, OR4F17, OR2W3, OR2AG2, OR6A2, OR56B4, OR5K2, OR2A42, OR1L8, OR2AE1, OR10AD1, OR2A1, GUCA1B, OR52W1, OR52I1, CAMK2B, PRKG1, CALML6, OR2L2, OR2A7, PRKACA",0.0904439707588247,0.0506099933550872,FALSE
+"A549","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.32718,1.2,0.198,728,0.461,"MTHFS, ATIC, MTFMT",0.703334809738469,0.336299074610352,FALSE
+"A549","Input","KEGG_OOCYTE_MEIOSIS",0.3606,1.34,0.12,3914,0.44,"YWHAQ, CALM2, RPS6KA3, RPS6KA6, PPP1CC, CDC27, CHP1, PPP2CB, IGF1R, SGO1, PRKX, PPP3R1, SLK, ANAPC5, SMC3, CUL1, AURKA, CCNE1, CCNB1, PPP3CA, CAMK2D, YWHAG, CCNB2, SKP1, CDC23, CDC26, BUB1, AR, PLK1, ANAPC7, ANAPC1, PPP2R5E, FBXW11, PPP1CB, CDK1, YWHAB, MAP2K1, ANAPC11, FBXO43, SMC1A, YWHAZ, PPP2R1A",0.920818753952375,0.356547323513813,FALSE
+"A549","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.55522,-1.99,0.00748,16382,0.59,"MAN2C1, MANBA, MAN2B2, NEU1, MAN2B1, NEU3",2.12609840213554,0.229147988357856,FALSE
+"A549","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.26587,-0.946,0.481,15105,0.712,"ATP6V1B1, ATP5PB, LHPP, NDUFA2, NDUFV3, UQCRB, NDUFA5, ATP6AP1, SDHD, COX8A, COX7C, UQCR10, ATP5PO, ATP6V1G2, NDUFA11, NDUFA3, NDUFA6, ATP5MG, NDUFS6, ATP5ME, NDUFC1, ATP6V0B, UQCRHL, ATP6V0C, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, NDUFS7, NDUFV1, COX5B",0.317854923626168,0.147520006363144,FALSE
+"A549","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.4791,1.73,0.0362,3741,0.246,"GCNT3, GALNT13, GALNT10, GALNT14, GALNT1, GALNT18, GALNT4, C1GALT1C1, GALNT16, GALNT2, GALNT7, C1GALT1",1.44129142946683,0.609064892896621,TRUE
+"A549","Input","KEGG_P53_SIGNALING_PATHWAY",0.25453,0.9,0.575,3564,0.702,"TP53I3, CCND3, SERPINE1, DDB2, RRM2B, TNFRSF10B, CASP8, CCNE1, CCNB1, CCNB3, APAF1, SFN, CDKN1A, CCNB2, FAS, CYCS, CDK1, IGFBP3, GADD45B, STEAP3",0.24033215531037,0.153662887870195,FALSE
+"A549","Input","KEGG_PANCREATIC_CANCER",-0.27333,-0.982,0.449,16063,0.698,"ARHGEF6, PIK3R1, E2F2, RALA, TGFB3, BRAF, PIK3CA, AKT1, PIK3R3, MAPK3, CDKN2A, VEGFA, RAC2, RALGDS, VEGFB, PIK3R2",0.347753658996677,0.156144577376839,FALSE
+"A549","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.17439,-0.63,0.979,11352,0.964,"VNN1, DPYS, ENPP3, UPB1, VNN2, PPCS, PANK4",0.00921730819686218,0.0159229660971692,FALSE
+"A549","Input","KEGG_PARKINSONS_DISEASE",-0.23122,-0.833,0.656,15433,0.834,"NDUFA2, NDUFV3, UQCRB, NDUFA5, SDHD, COX8A, COX7C, PRKN, UQCR10, SNCA, ATP5PO, NDUFA3, NDUFA6, UBE2J2, UBE2L6, UBE2G2, NDUFS6, NDUFC1, UQCRHL, NDUFB7, ATP5F1D, UQCR11, NDUFA7, ATP5F1E, UBA7, NDUFS7, NDUFV1, COX5B",0.18309616062434,0.0788339493622613,FALSE
+"A549","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.38862,1.42,0.0905,2529,0.393,"YWHAQ, ROCK2, TUBA4A, ARPC3, NCL, ITGB1, KRT18, ACTG1, TUBAL3, RHOA, PRKCA, EZR, CLDN1, ARPC4, TUBA1C, TUBA1B, ACTB",1.0433514207948,0.405607449624573,FALSE
+"A549","Input","KEGG_PATHWAYS_IN_CANCER",-0.21416,-0.763,0.808,15302,0.899,"LAMA4, IL6, AXIN2, PIAS4, CCNA1, FGFR3, RXRA, FZD7, AXIN1, DVL2, ARNT, RBX1, PDGFRB, CBLC, FGF22, WNT10A, CBL, PIK3R1, LAMA1, SKP2, RASSF5, DVL1, EP300, HDAC1, MMP1, FGF12, PTCH1, WNT2B, PAX8, TRAF4, E2F2, SUFU, STK36, BMP2, FGF13, BCL2, RALA, ELOB, TGFB3, FGFR2, BRAF, LEF1, PIK3CA, RASSF1, AKT1, CCNE2, WNT5A, FGF11, FZD4, CDKN1B, CRKL, CREBBP, CDKN2B, PIAS3, RUNX1, PLCG1, PIK3R3, FZD1, MAPK3, CDKN2A, GLI3, MTOR, FLT3LG, VEGFA, RAC2, RALGDS, MAX, MECOM, CTBP1, VEGFB, FOS, BCR, PPARD, DVL3, PML, RXRB, PIK3R2",0.0925886392254138,0.0462403082667712,FALSE
+"A549","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.53474,1.94,0.0143,1276,0.137,"UGDH, AKR1B1, RPE, RPEL1, UGP2",1.84466396253494,0.863279432843593,TRUE
+"A549","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.45145,1.64,0.0411,1965,0.259,"PGD, G6PD, TKT, GPI, RPE, RPEL1, RBKS, PFKP, PRPS1, TALDO1",1.38615817812393,0.586700235918748,FALSE
+"A549","Input","KEGG_PEROXISOME",-0.27864,-0.985,0.425,15908,0.72,"PAOX, PMVK, PEX3, PEX6, PEX11G, PEX1, PXMP2, PEX11B, PEX19, PEX10, PRDX5, ACSL5, IDH2, FAR2, PEX16, PEX26, ABCD4, PEX7, ACOT8, ABCD1, HMGCL, PEX14",0.371611069949688,0.142667503568732,FALSE
+"A549","Input","KEGG_PHENYLALANINE_METABOLISM",0.3522,1.3,0.132,1539,0.446,"ALDH3A1, GOT2, ALDH3B1",0.87942606879415,0.350665141287858,FALSE
+"A549","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.3203,-1.18,0.209,15324,0.766,"PLCB2, PLCB1, INPP5J, CALML6, CDS1, PIK3R1, ITPR3, PLCB3, ITPKB, PIK3CA, INPP5B, ITPKA, PI4KB, DGKZ, DGKQ, SYNJ1, PLCG1, INPPL1, PIK3R3, INPP5E, PI4KA, PIP5K1C, PIK3R2",0.679853713888946,0.115771230367396,FALSE
+"A549","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.33456,1.23,0.183,2727,0.463,"HMOX1, EARS2, COX15, COX10, BLVRB, HCCS, FECH, FTH1, ALAS1",0.737548910269571,0.334419008982047,FALSE
+"A549","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.22384,-0.799,0.749,17311,0.867,"ACSL5, SORBS1, PLTP, SLC27A1, PPARA, PPARD, CPT2, RXRB",0.125518182300534,0.0619809025237897,FALSE
+"A549","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45993,1.71,0.0246,3031,0.246,"BAAT, AKR1C4, HSD3B7, SLC27A5, ACOX2",1.60906489289662,0.609064892896621,TRUE
+"A549","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.33263,-1.19,0.206,12250,0.811,"CD3D, CD19, IL2RG, IGLL1, LCK, RAG1, BLNK, JAK3, DCLRE1C, CIITA, TAP2, IL7R, TNFRSF13C, RFXAP, RFXANK",0.686132779630847,0.090979145788844,FALSE
+"A549","Input","KEGG_PRION_DISEASES",-0.29271,-1.06,0.324,15251,0.624,"CCL5, IL6, IL1B, NCAM2, ELK1, NCAM1, NOTCH1, PRKACA, MAPK3, FYN, EGR1",0.489454989793388,0.204815410317576,FALSE
+"A549","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21174,-0.755,0.796,15123,0.889,"MAPK10, RPS6KA1, CCNA1, ANAPC2, MAPK12, PKMYT1, PIK3R1, MAPK14, BRAF, PIK3CA, AKT1, PRKACA, FZR1, PIK3R3, MAD2L2, MAPK3, MAPK13, RPS6KA2, GNAI2, PIK3R2",0.0990869322623309,0.0510982390297863,FALSE
+"A549","Input","KEGG_PROPANOATE_METABOLISM",0.35508,1.29,0.164,3700,0.436,"ALDH3A2, ALDH1B1, LDHA, LDHB, SUCLG1, HADHA, ACACA, HIBCH, ALDH2, ACACB, ECHS1, SUCLA2, ACAT1",0.785156151952302,0.360513510731414,FALSE
+"A549","Input","KEGG_PROSTATE_CANCER",-0.2988,-1.07,0.332,15622,0.665,"CREB3L1, PDGFRB, PDGFC, PIK3R1, CREB3L2, EP300, E2F2, BCL2, FGFR2, BRAF, LEF1, PIK3CA, AKT1, CCNE2, CDKN1B, CREBBP, ATF4, CREB3L4, PIK3R3, MAPK3, MTOR, CREB5, PIK3R2",0.478861916295964,0.177178354696895,FALSE
+"A549","Input","KEGG_PROTEASOME",0.49313,1.78,0.023,3432,0.219,"PSMA4, PSMC4, PSMB6, PSMD12, PSME3, PSMD8, PSMD1, PSMD11, PSMD14, PSME4, PSMC5, PSMA1, PSMB5, PSMA6, POMP, PSMC6, PSMC1, PSMA3, PSMA2, PSMF1, PSMB3",1.63827216398241,0.659555885159882,TRUE
+"A549","Input","KEGG_PROTEIN_EXPORT",0.29925,1.1,0.274,3377,0.538,"SEC11A, OXA1L, SRP68, SEC61A2, SEC62, SEC11C, SRP72",0.562249437179612,0.269217724333611,FALSE
+"A549","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.31653,1.14,0.284,3303,0.534,"FXYD2, GLS, ATP1B1, GLUD2, MDH1, GLUD1, ATP1B3",0.546681659952962,0.272458742971444,FALSE
+"A549","Input","KEGG_PURINE_METABOLISM",0.36439,1.31,0.146,2835,0.444,"PDE11A, PDE4D, PDE3A, ATIC, PDE10A, PDE8A, NME1, PDE7B, PDE4B, POLR2I, PRIM1, DGUOK, NT5C2, ADA, PDE1A, POLR1E, PDE1C, PRPS1, RRM2B, NME2, PAPSS2, POLE4, POLR2C, GMPS, POLE2, PNP, PKM, NME4, PFAS, HPRT1, POLA1, PNPT1, POLR3K, POLR3G, POLR3F, ADPRM, POLD4, RRM1, PDE6G, PAICS",0.835647144215563,0.35261702988538,FALSE
+"A549","Input","KEGG_PYRIMIDINE_METABOLISM",0.38387,1.37,0.113,4771,0.406,"CTPS1, TXNRD1, NME1, UMPS, POLR2I, PRIM1, NT5C2, CDA, POLR1E, RRM2B, NME2, POLE4, POLR2C, UCK2, POLE2, PNP, NME4, POLA1, PNPT1, POLR3K, POLR3G, DTYMK, POLR3F, POLD4, RRM1, CMPK1, POLR3D, NT5C, POLR1B, AK3, POLR2D, UPRT, POLE3, DHODH, TK1, NME7, POLR2L, ITPA, NT5C3A, POLR3H, POLR3C, POLR3B, CTPS2, POLR1D, POLR1A, TXNRD2",0.94692155651658,0.391473966422806,FALSE
+"A549","Input","KEGG_PYRUVATE_METABOLISM",0.44128,1.6,0.0474,2894,0.27,"AKR1B1, ME1, ALDH3A2, ALDH1B1, LDHA, DLD, LDHB, PC, ME2, MDH1, PKM, ACACA, ALDH2, ME3",1.32422165832591,0.568636235841013,FALSE
+"A549","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.19725,0.728,0.833,4136,0.886,"PDGFD, ROCK2, ITGAV, ITGAM, ARPC3, ITGAE, F2, CRK, ITGB1, FGF2, PPP1CC, GNA13, VAV1, ITGA11, NCKAP1, TMSB4Y, ACTG1, ACTN4, CFL2, ITGB5, VCL, RHOA, CFL1, TMSB4X, HRAS, CYFIP2, EZR, FGFR1, FGFR4, ARPC4, ACTB, RDX, ENAH, PFN1, GNG12, PPP1R12A, RRAS, SSH2, MSN, EGFR, CYFIP1, PPP1CB, SOS1, PTK2, RRAS2, MAP2K1, F2R, ACTN1, VAV3, BRK1, APC, PXN, ITGB6, BDKRB2, DOCK1, ITGA2B, KRAS, PFN4, SOS2, FN1",0.0793549985932124,0.0525662781129492,FALSE
+"A549","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.33093,1.22,0.178,3285,0.469,"IFNA13, ULK1, ULK2, PRKAA2, ATG7, ATG4C",0.749579997691106,0.328827157284917,FALSE
+"A549","Input","KEGG_RENAL_CELL_CARCINOMA",-0.30778,-1.1,0.283,15797,0.667,"ARNT, RBX1, PIK3R1, RAP1A, EP300, ELOB, TGFB3, BRAF, PIK3CA, AKT1, GAB1, CRKL, CREBBP, PAK6, PAK2, PIK3R3, MAPK3, VEGFA, VEGFB, PIK3R2",0.54821356447571,0.175874166083451,FALSE
+"A549","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.23516,0.869,0.616,1808,0.733,"NLN, AGTR1",0.210419287835575,0.134896025358872,FALSE
+"A549","Input","KEGG_RETINOL_METABOLISM",0.29618,1.1,0.289,3817,0.538,"ALDH1A1, CYP26A1, BCO1, CYP26B1, DHRS3, DHRS4, CYP2C9, DHRS4L2, RDH11, RDH5, PNPLA4",0.539102157243452,0.269217724333611,FALSE
+"A549","Input","KEGG_RIBOFLAVIN_METABOLISM",0.43987,1.58,0.0672,409,0.277,"RFK, ACP1",1.17263072694617,0.557520230935551,FALSE
+"A549","Input","KEGG_RIBOSOME",-0.31709,-1.11,0.276,16409,0.682,"RPS23, RPL9, RPL38, RPS21, RPL28, RPS25, RPS8, RPL18A, RPS15, RPS10, RPL3, RPL22, RPS18, RPL13, RPS28, RPS12, RPL35A, RPL37, RPL36, FAU",0.559090917934782,0.166215625343521,FALSE
+"A549","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.2012,0.752,0.82,2264,0.89,"IFNA13, TBK1, DDX3Y, TRAF2, DDX3X, CHUK, IFNE, NFKBIB, CASP8",0.0861861476162833,0.0506099933550872,FALSE
+"A549","Input","KEGG_RNA_DEGRADATION",0.27831,1.03,0.371,3655,0.571,"PARN, ENO3, HSPD1, XRN2, EXOSC5, PAPOLA, HSPA9, WDR61, LSM5, PNPT1, CNOT7, C1D, PAPOLG, EXOSC1, ENO1, MPHOSPH6, CNOT9, CNOT1, LSM1, EXOSC3",0.430626090384954,0.243363891754152,FALSE
+"A549","Input","KEGG_RNA_POLYMERASE",0.32365,1.18,0.229,4747,0.484,"POLR2I, POLR1E, POLR2C, POLR3K, POLR3G, POLR3F, POLR3D, POLR1B, POLR2D, POLR2L, POLR3H, POLR3C, POLR3B, POLR1D, POLR1A",0.640164517660112,0.315154638355588,FALSE
+"A549","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.25081,0.9,0.551,4652,0.702,"GGT1, METTL6, PAPSS2, METTL2B, MAT2A, BUD23, SEPHS1, AHCYL1, AHCY, MARS2, MAT2B",0.258848401148215,0.153662887870195,FALSE
+"A549","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.23175,0.844,0.65,3074,0.759,"RARB, COL4A4, ITGAV, TRAF2, ITGB1, COL4A6, AKT2, BIRC3, CHUK, CKS1B, COL4A1, CCNE1, AKT3, APAF1, PTGS2, TRAF3, PIAS1, COL4A2, BCL2L1, CYCS, LAMC2",0.187086643357144,0.11975822410452,FALSE
+"A549","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.45204,-1.62,0.0289,16460,0.632,"VAMP4, STX10, STX16, STX12, SEC22B, STX5, VAMP5, TSNARE1, VAMP2, STX3, SNAP29, USE1, SNAP23",1.53910215724345,0.199282921717615,FALSE
+"A549","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33046,1.21,0.179,3275,0.475,"GLA, GAL3ST1, SGMS1, DEGS1, ASAH2, GALC, PLPP1, ACER3, SPTLC2, SGPP1, SPTLC1, PLPP2",0.747146969020107,0.323306390375133,FALSE
+"A549","Input","KEGG_SPLICEOSOME",-0.30687,-1.12,0.266,17451,0.725,"DHX16, PRPF6, SNU13, TRA2B, LSM4, PRPF38B, SRSF4, CCDC12, PPIH, SYF2, SF3A1, HNRNPA1L2, SNRPD1, LSM7, MAGOH, SNRPD3, LSM6, CWC15, SRSF5, NCBP2, DDX39B, CHERP, XAB2, PRPF38A, SF3A2",0.575118363368933,0.139661993429006,FALSE
+"A549","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.25014,0.897,0.531,1700,0.699,"UGDH, PGM2L1, GPI, UGP2, MGAM",0.274905478918531,0.155522824254319,FALSE
+"A549","Input","KEGG_STEROID_BIOSYNTHESIS",-0.44337,-1.58,0.0479,15767,0.631,"CEL, SC5D, CYP27B1, TM7SF2, DHCR24, LSS",1.31966448658544,0.199970640755866,FALSE
+"A549","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.42547,1.54,0.0629,1711,0.292,"AKR1C2, AKR1C3, SULT2B1, AKR1C1, SRD5A2, HSD17B6, AKR1C4",1.20134935455473,0.534617148551582,FALSE
+"A549","Input","KEGG_SULFUR_METABOLISM",0.36038,1.31,0.147,2967,0.444,"SULT2B1, CHST11, PAPSS2, SULT1A4",0.832682665251824,0.35261702988538,FALSE
+"A549","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.43534,1.56,0.0379,1426,0.283,"GRIN2B, C5, SNRPB, SSB, C1S, ACTN4",1.42136079003193,0.54821356447571,FALSE
+"A549","Input","KEGG_TASTE_TRANSDUCTION",0.24979,0.912,0.536,1430,0.702,"TAS2R50, TAS2R9, PDE1A, ASIC2, TAS2R14, PRKX",0.27083521030723,0.153662887870195,FALSE
+"A549","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",0.53176,1.91,0.0128,374,0.142,"BAAT, GGT1",1.89279003035213,0.847711655616944,TRUE
+"A549","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.32003,-1.14,0.263,15900,0.751,"DHDDS, PMVK, FDPS, MVD",0.580044251510242,0.124360062995832,FALSE
+"A549","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28987,1.05,0.334,3397,0.551,"BMPR1B, ROCK2, TGFBR1, TGFB2, BMPR1A, BMP6, PPP2CB, INHBB, SMAD3, RHOA, CUL1, SMAD2, RBL1, SMAD6, LTBP1, SMAD7, RPS6KB1, AMHR2, ZFYVE16, BMPR2, SKP1, TGFBR2, ID3, SMAD4, ID2",0.476253533188435,0.258848401148215,FALSE
+"A549","Input","KEGG_THYROID_CANCER",-0.30502,-1.11,0.27,16623,0.682,"PAX8, BRAF, LEF1, MAPK3, RXRB",0.568636235841013,0.166215625343521,FALSE
+"A549","Input","KEGG_TIGHT_JUNCTION",0.20647,0.76,0.787,2568,0.903,"PRKCQ, PARD3, PPP2R2C, SRC, TJP1, AKT2, PPP2CB, ACTG1, ACTN4, PPP2R2A, MAP3K20, RAB3B, RHOA, PRKCA, HRAS, CSNK2A1, MPDZ, CLDN1, CLDN2, AKT3, ACTB, CLDN23",0.104025267640935,0.0443122496864942,FALSE
+"A549","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23446,-0.845,0.644,15123,0.821,"MAPK10, JUN, CCL5, IL6, IL1B, TLR5, MAPK12, TLR4, PIK3R1, TLR2, MAPK14, TIRAP, LY96, PIK3CA, AKT1, TLR3, TOLLIP, IFNAR1, PIK3R3, MAPK3, IRF7, MAPK13, TICAM1, TAB1, FOS, MAP2K7, PIK3R2",0.191114132640188,0.0856568428805592,FALSE
+"A549","Input","KEGG_TRYPTOPHAN_METABOLISM",0.25942,0.956,0.48,3700,0.689,"KYNU, ALDH3A2, ALDH1B1, IDO2, HADHA, ALDH2, AFMID, AADAT, TDO2, AOX1, ECHS1, ACAT1",0.318758762624413,0.161780778092374,FALSE
+"A549","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.3654,-1.33,0.136,12793,0.929,"MAFA, CACNA1B, PDX1, IKBKB, CACNA1A, GCK, TNF, SLC2A4, HK1, CACNA1C, MAPK10, PRKCD, KCNJ11, PIK3R1, INSR, PIK3CA, SOCS1, PIK3R3, MAPK3, MTOR, PIK3R2, HK2",0.866461091629782,0.0319842860063582,FALSE
+"A549","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.2424,-0.862,0.609,11839,0.808,"PTPRN2, IL12A, CD86, GZMB, TNF, IL1A, IL1B, CPE, ICA1, GAD1",0.215382707367125,0.0925886392254138,FALSE
+"A549","Input","KEGG_TYROSINE_METABOLISM",0.27577,1.02,0.419,1856,0.582,"HGD, ALDH3A1, GOT2, ALDH3B1, METTL6, METTL2B",0.377785977033705,0.235077015350112,FALSE
+"A549","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.21793,-0.793,0.763,15885,0.866,"CBLC, MAPK12, CBL, PIK3R1, BCL10, MAPK14, PIK3CA, AKT1, NCK2, PAK6, LAT, PAK2, PLCG1, PIK3R3, MAPK3, NFATC4, DLG1, MAPK13, FYN, FOS, MAP2K7, PIK3R2",0.11747546204512,0.0624821079826534,FALSE
+"A549","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.26016,0.949,0.479,3348,0.668,"NEDD4, UBA2, CUL3, UBE2G1, HERC4, UBE2A, BIRC6, CDC27, UBE2Q2, UBE2S, DDB2, BIRC3, MID1, BRCA1, ANAPC5, ERCC8, WWP1, CUL1, FANCL, UBE2D1, SAE1, TRIM32, UBE2E1, CUL2, KLHL9, UBE2N, SKP1, CDC23, PIAS1, UBE2D2, CDC26, TRIM37, UBE2M, ANAPC7, ANAPC1, FBXW11, ELOC",0.319664486585437,0.175223537524454,FALSE
+"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.33611,-1.2,0.195,18726,0.821,"VARS2",0.709965388637482,0.0856568428805592,FALSE
+"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.38891,-1.39,0.108,18177,0.808,"PCCB, BCKDHB, ACAD8, HADH, MCCC1, ALDH6A1, IVD, OXCT1, HMGCL",0.96657624451305,0.0925886392254138,FALSE
+"A549","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.19282,0.683,0.905,2257,0.923,"PPP1R14A, PRKCQ, ROCK2, CALM2, PPP1CC, ADRA1B, GNA13, PLA2G4A, PLCB4, PRKX, RHOA, AGTR1, PRKCA, CALD1",0.0433514207947967,0.0347982989740879,FALSE
+"A549","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.27591,-1,0.404,15622,0.714,"CREB3L1, GNAS, CREB3L2, ARHGDIB, RAB5B, DYNC1I1, PRKACA, CREB3L4, RAB11B, VAMP2, CREB5, DYNLL2",0.393618634889395,0.146301788223826,FALSE
+"A549","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.33062,-1.18,0.238,15995,0.766,"MAPK12, MAPKAPK2, PIK3R1, SHC2, MAPK14, PIK3CA, AKT1, PLA2G12A, MAPKAPK3, PLCG1, PIK3R3, PLA2G6, MAPK3, NFATC4, PLA2G4B, VEGFA, RAC2, MAPK13, PIK3R2",0.623423042943488,0.115771230367396,FALSE
+"A549","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.21946,0.81,0.715,2529,0.812,"ATP6V1E2, TJP1, KDELR1, ACTG1, PRKX, ATP6V0E1, PRKCA, SLC12A2, SEC61A2, ACTB",0.145693958198919,0.0904439707588247,FALSE
+"A549","Input","KEGG_VIRAL_MYOCARDITIS",0.20678,0.756,0.832,2529,0.901,"SGCD, EIF4G2, ACTG1, SGCA, CAV1, CASP8, ACTB",0.0798766737092761,0.045275209020937,FALSE
+"A549","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24656,-0.871,0.637,14908,0.815,"RAC3, CAMK2B, MAPK10, NFATC1, CCND2, JUN, PLCB2, PLCB1, DAAM2, AXIN2, CHD8, LRP5, FZD7, AXIN1, DVL2, RBX1, WNT10A, PPP2R5D, DVL1, EP300, PLCB3, SENP2, WNT2B, LEF1, WNT5A, FZD4, PRKACA, PRICKLE1, CREBBP, FRAT2, PORCN, PPP2R5B, FZD1, FRAT1, NFATC4, RAC2, CSNK2B, CTBP1, TBL1XR1, CSNK1E, PPARD, CTNNBIP1, DVL3",0.19586056766465,0.0888423912600234,FALSE
+"H1703","Input","KEGG_ABC_TRANSPORTERS",-0.3575,-1.27,0.163,14274,0.559,"ABCB11, ABCC2, ABCA8, ABCC9, ABCA6, CFTR, ABCA4, ABCB4, ABCB9, ABCA13, ABCA12, ABCD3, ABCB1, ABCA10, ABCA1, ABCC1, ABCG2, ABCC6, ABCG1, ABCD4, ABCC3, ABCA5, ABCB6",0.787812395596042,0.252588192113577,FALSE
+"H1703","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.38364,1.22,0.189,3007,0.567,"EIF4EBP1, STAT3, GRB2, FLT3, MTOR, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, RPS6KB1",0.723538195826756,0.246416941107093,FALSE
+"H1703","Input","KEGG_ADHERENS_JUNCTION",0.29159,0.946,0.533,3288,0.743,"RAC1, SMAD2, VCL, FGFR1, WASF1, MAP3K7, TGFBR2, EP300, MAPK1, CSNK2B, CTNNA1, SMAD4, AFDN, YES1, IQGAP1, WASF2, NLK, SSX2IP, NECTIN2, RHOA",0.273272790973428,0.129011186239425,FALSE
+"H1703","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.39435,1.26,0.172,3697,0.579,"STAT3, ADIPOR2, MAPK9, SOCS3, PRKAG2, PRKAA1, NFKBIE, STK11, MAPK8, MTOR, PTPN11, TNFRSF1A, CHUK, NFKB1, IKBKG, AKT1, PCK2, LEPR, CPT1A, CAMKK2, AKT3, NFKBIB",0.764471553092451,0.237321436272564,FALSE
+"H1703","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.25462,0.82,0.735,3341,0.829,"ADSL, CAD, ASNS, GOT1, NIT2, GLUD1, ASL",0.133712660915805,0.0814454694497265,FALSE
+"H1703","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.17903,0.581,0.98,3422,1,"SGK1, NEDD4L, MAPK1, KRAS, ATP1A3, PRKCA",0.00877392430750515,0,FALSE
+"H1703","Input","KEGG_ALLOGRAFT_REJECTION",0.24222,0.775,0.803,14486,0.884,"CD40, IL12B, IL5, IL12A, IFNG, CD28, CD40LG, IL2, FASLG, CD80, IL4, IL10, PRF1, TNF, FAS, CD86, GZMB",0.095284454721319,0.0535477349869269,FALSE
+"H1703","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.47522,-1.78,0.0291,12060,0.363,"PLA2G2A, PLA2G5, PLA2G2C, PLA2G2F, PLA2G4B, PLA2G4E, PLA2G6, PLA2G3, ACOX1, PLA2G10, FADS2, PLA2G4A",1.53610701101409,0.440093374963888,FALSE
+"H1703","Input","KEGG_ALZHEIMERS_DISEASE",0.27885,0.897,0.587,4485,0.777,"GRIN2B, NDUFS6, ITPR2, SDHA, APH1A, NDUFA9, ATP2A1, GAPDH, NDUFA1, ATP5F1A, COX7A2L, IDE, TNFRSF1A, PLCB3, CALML6, PLCB4, MAPK1, NDUFS4, NDUFA3, PPP3R2, CYCS, BID, CYC1, PPP3CB, ATP5F1D, SDHB, NAE1, NDUFS3, ADAM17, CALM3, NDUFA6, NDUFA10, NDUFB8, ATP2A3, ATP5F1C, UQCRHL, UQCRFS1, NDUFC1, PSEN2, BAD, LRP1",0.231361898752386,0.109578981199086,FALSE
+"H1703","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.48167,1.56,0.0385,3842,0.429,"YARS2, RARS2, IARS2, HARS2, TARS2, FARSA, AARS2, FARS2",1.4145392704915,0.367542707815276,FALSE
+"H1703","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.23372,-0.86,0.606,16354,0.742,"GCK, NPL, GFPT2, RENBP, GFPT1, MPI, GALE, UGDH, HK2, NAGK",0.217527375833714,0.129596094720973,FALSE
+"H1703","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.34517,1.11,0.298,2986,0.598,"GRIN2B, MAPK11, NEFH, MAPK12, RAC1, DAXX, TNFRSF1A, PPP3R2, CYCS, BID, PPP3CB, MAPK14",0.525783735923745,0.223298816011589,FALSE
+"H1703","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.45574,1.46,0.0663,3014,0.392,"NFYB, HSPA4, KLRC2, KLRC4, HSPA1L, HSP90AB1, TAP2, RFX5, KLRC3, TAP1, PSME3, NFYC, HSPA1A, TAPBP, RFXANK",1.17848647159523,0.406713932979543,FALSE
+"H1703","Input","KEGG_APOPTOSIS",0.34432,1.12,0.268,5095,0.586,"MAP3K14, AIFM1, BIRC3, PRKAR2A, BIRC2, TNFRSF1A, DFFA, CHUK, PRKAR2B, NFKB1, IKBKG, AKT1, XIAP, PPP3R2, CYCS, RIPK1, IRAK1, BID, PPP3CB, PRKACA, AKT3, BAX, MYD88, TRAF2, NFKBIA, BAD, ATM, PIK3CB, IRAK2, PRKAR1B, IKBKB, EXOG, TRADD",0.571865205971211,0.232102383981909,FALSE
+"H1703","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.44904,-1.59,0.0563,15113,0.378,"PTGIS, GGT6, CYP2J2, GGT5, PLA2G10, CYP4F3, ALOX5, PTGS1, GPX2, PTGS2, LTC4S, GPX3, GPX7, AKR1C3, PLA2G4A, TBXAS1, PTGES, EPHX2, GGT7, CBR3, GPX1",1.24949160514865,0.422508200162775,FALSE
+"H1703","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.33675,-1.18,0.211,17949,0.53,"AGMAT, CPS1, CKMT1A, MAOA, CKMT1B, NAGS, ALDH2, ARG2, ASS1, SAT2",0.675717544702307,0.275724130399211,FALSE
+"H1703","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.31601,-1.16,0.244,16215,0.546,"DSC2, CACNA1C, ITGA11, TCF7L2, CACNA2D3, CACNG6, RYR2, SLC8A1, CACNA1D, ITGB3, LEF1, ITGA7, ITGB6, DSG2, ITGA1, GJA1, ITGB4, ACTN4, ITGB8, ITGA2",0.612610173661271,0.262807357295263,FALSE
+"H1703","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.23666,-0.86,0.658,18008,0.742,"UGDH, ALDH2",0.181774106386044,0.129596094720973,FALSE
+"H1703","Input","KEGG_ASTHMA",0.2476,0.801,0.758,14383,0.848,"CD40, IL13, IL5, IL9, MS4A2, EPX, FCER1A, FCER1G, CD40LG, IL3, CCL11, IL4, IL10, TNF, PRG2, RNASE3",0.120330794367946,0.0716041477432862,FALSE
+"H1703","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",-0.28368,-1.06,0.332,9594,0.647,"IFNA4, IFNA17, IFNA6, IFNA16, IFNA10, IFNA2, IFNA7, IFNA14, CD28, CD40LG, IL2, TPO, FASLG, TSHB, CD80, IFNA13, IL4, CTLA4, IL10, IFNA21, TG, PRF1, TSHR, CGA, FAS, IFNA5, CD86, GZMB",0.478861916295964,0.1890957193313,FALSE
+"H1703","Input","KEGG_AXON_GUIDANCE",-0.25682,-0.946,0.462,15670,0.703,"EPHA7, CXCL12, SEMA3G, ABLIM1, EPHB6, ROBO2, EPHA1, EPHA3, PLXNC1, EPHA5, PAK3, EPHA6, FES, SEMA6D, NTNG1, FYN, PLXNB1, SEMA4F, SEMA4A, ABLIM2, RND1, NFATC2, SLIT2, SEMA5A, SEMA7A, EPHB2, EFNB3, PAK6, HRAS, EPHA4, EPHB3, PLXNA2, SEMA3B, RAC2, NFATC4, NRP1, PLXNB3, ABLIM3, NTN4, EFNB2, PLXNA3, RGS3",0.335358024443874,0.153044674980176,FALSE
+"H1703","Input","KEGG_BASAL_CELL_CARCINOMA",-0.225,-0.82,0.695,15333,0.802,"HHIP, PTCH1, WNT7B, TP53, WNT7A, SHH, WNT10A, TCF7L2, WNT11, WNT3, LEF1, FZD9, FZD4, FZD8, BMP2, WNT5A, FZD7, BMP4, GLI3, FZD3",0.158015195409886,0.0958256317158365,FALSE
+"H1703","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.48489,1.56,0.0392,3630,0.429,"TAF9, TBP, GTF2H2, TAF9B, TAF1, TAF5, TAF4B, TAF6, TAF7, TAF2, TAF11, TBPL1, GTF2A1L, TAF5L, TAF1L, GTF2A2",1.40671393297954,0.367542707815276,FALSE
+"H1703","Input","KEGG_BASE_EXCISION_REPAIR",0.51093,1.65,0.0291,7134,0.414,"OGG1, POLD2, POLD1, UNG, PARP1, NEIL2, POLL, POLE, LIG1, POLE2, MPG, MBD4, LIG3, NEIL3, NTHL1, PARP4, POLD3, TDG, NEIL1, POLE3, MUTYH, APEX2, FEN1, PARP3, HMGB1, POLB",1.53610701101409,0.382999658879101,FALSE
+"H1703","Input","KEGG_BETA_ALANINE_METABOLISM",0.46985,1.52,0.0423,3228,0.413,"AOC2, AOC3, SMS, ALDH3A2, DPYS, HADHA, SRM, ALDH9A1",1.37365963262496,0.384049948343599,FALSE
+"H1703","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.2599,-0.935,0.495,16509,0.695,"PECR, FADS2, HSD17B12, ACOT4, TECR, ELOVL6",0.305394801066431,0.158015195409886,FALSE
+"H1703","Input","KEGG_BLADDER_CANCER",0.28469,0.931,0.542,2591,0.734,"VEGFD, E2F2, MAPK1, E2F3, E2F1, CDKN2A, KRAS, RAF1, NRAS, MAP2K2",0.266000713461613,0.134303940083929,FALSE
+"H1703","Input","KEGG_BUTANOATE_METABOLISM",-0.3172,-1.18,0.213,17676,0.53,"ABAT, ACSM3, ALDH2, BDH2, BDH1, ACADS",0.671620396561262,0.275724130399211,FALSE
+"H1703","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.36606,1.18,0.227,2705,0.568,"LILRB3, MALT1, NFATC1, RAC1, NFKBIE, GRB2, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, PPP3CB",0.643974142806877,0.245651664288981,FALSE
+"H1703","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.25934,0.833,0.705,2936,0.828,"PDGFRA, TBXA2R, CACNA1A, GNAL, ITPR2, ATP2A1, PHKA1, CACNA1G, ADORA2A, VDAC2, HRH1, PPID, PLCE1, TRHR, PLCB3, CALML6, PLCB4, ADCY3, CACNA1H, VDAC1, SLC25A5, PPP3R2, CACNA1B, PPP3CB, PLCD4, PRKACA, PHKA2",0.151810883008601,0.0819696632151199,FALSE
+"H1703","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.17124,0.555,0.984,6539,1,"CACNB1, SLC9A6, COX7A2L, TPM2, TPM3, CYC1, ATP1A3, CACNB4, CACNA2D1, UQCRHL, UQCRFS1, TNNC1, COX7C, UQCRC1, TPM1, UQCR11, COX6C, UQCRB, ATP1B3, UQCRC2, CACNB3, CACNG4, UQCR10, COX7B",0.00700490156865849,0,FALSE
+"H1703","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.27553,-1.02,0.399,14211,0.609,"ITGAL, CD86, PECAM1, CDH15, ITGB2, CLDN10, CLDN2, CADM3, NRXN2, CLDN9, CLDN14, CD34, CLDN16, CDH5, NCAM2, VCAM1, SELL, JAM2, NLGN4X, CD6, CNTNAP2, MPZ, CD22, CLDN22, CD4, PDCD1LG2, CNTN1, NLGN1, CLDN11, SDC2, NRXN3, ICAM2, GLG1, NCAM1, CDH1, CLDN3, VCAN, CDH3, NRCAM, CD274, CLDN23, CADM1, NECTIN3, CLDN7, CLDN4, ICAM3, ITGB8, ICAM1, F11R",0.399027104313252,0.215382707367125,FALSE
+"H1703","Input","KEGG_CELL_CYCLE",0.47154,1.5,0.0663,6373,0.401,"CCNB3, CCND2, SMAD2, MCM5, CHEK2, MAD2L2, ORC3, YWHAH, E2F2, MCM3, ESPL1, EP300, E2F3, ORC5, E2F1, CDKN2A, CDC25B, CDC45, HDAC2, YWHAE, CDC25A, SMAD4, CDC20, CCNB1, PRKDC, E2F5, SMC1B, CDC27, TTK, PTTG2, ANAPC1, ANAPC7, CCNA2, ANAPC4, CHEK1, FZR1, PKMYT1, RAD21, STAG2, CDC23, CDC6, MCM2, YWHAQ, RB1, TGFB1, PLK1, BUB1B, BUB1, ATM, CREBBP, CCNE2, SMC3, SMAD3, SMC1A, GADD45B, STAG1, CDKN1B, MAD2L1, CDK2, CCND3, TFDP1, MAD1L1, RBX1, YWHAG, MCM6, TFDP2, ATR, E2F4, CDC16, ABL1, MCM7, CDC7, CDK7, CDK1, ORC1, YWHAB, CDKN2C, YWHAZ, CDKN2B, PTTG1",1.17848647159523,0.396855627379818,FALSE
+"H1703","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.26517,0.851,0.648,2894,0.807,"RAC1, CCR10, STAT3, SHC1, GRK3, ROCK1, GRK6, GNG13, GRB2, CCL28, CRKL, CCL2, PLCB3, XCL1, CHUK, PLCB4, ADCY3, CSK, MAPK1, CRK, NFKB1, IKBKG, AKT1, KRAS, SOS1, RAF1, CCL5, NRAS, GNB5, GNB2, ARRB2, GNB4, PRKACA",0.188424994129407,0.0931264652779296,FALSE
+"H1703","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.37914,1.22,0.186,2591,0.567,"SHC1, GRB2, E2F2, CRKL, CBL, PTPN11, TGFBR2, CHUK, MAPK1, CRK, E2F3, NFKB1, E2F1, IKBKG, CDKN2A, AKT1, KRAS, HDAC2, SOS1, RAF1, CTBP1, NRAS, SMAD4, MAP2K2",0.730487055782084,0.246416941107093,FALSE
+"H1703","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.36992,1.21,0.192,3869,0.538,"CLOCK, CRY1, PER3, CSNK1D, PER1, CSNK1E",0.71669877129645,0.269217724333611,FALSE
+"H1703","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.33418,1.07,0.337,4539,0.613,"PDHA1, SDHA, ACO2, PCK2, SDHB, OGDH, ACLY, IDH3B, IDH3G, SUCLA2, IDH3A",0.472370099128661,0.212539525481585,FALSE
+"H1703","Input","KEGG_COLORECTAL_CANCER",0.4612,1.49,0.063,5062,0.396,"APC2, RAC1, SMAD2, MAPK9, APC, MAPK8, TGFBR2, MAPK1, MSH6, AKT1, KRAS, MSH2, RAF1, SMAD4, CYCS, MLH1, RHOA, FOS, AKT3, BAX, TGFB1, MSH3, BAD, SMAD3, CTNNB1, PIK3CB, AXIN1, BIRC5, APPL1, AXIN2",1.20065945054642,0.402304814074488,FALSE
+"H1703","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.33426,-1.2,0.231,14193,0.558,"C5, MASP1, C4A, SERPIND1, F10, VWF, KLKB1, PROC, A2M, PLAUR, SERPINA5, C4BPB, C1R, CFI, BDKRB1, SERPING1, SERPINA1, THBD, C2, CFB, CD46, C3, BDKRB2, CFH, CD55, PLAU, CD59, PLAT, F3",0.636388020107856,0.253365801062421,FALSE
+"H1703","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.26228,0.863,0.655,2883,0.807,"SMS, GOT1, CBS, DNMT1, AHCY, LDHB, SRM, MPST",0.183758700008217,0.0931264652779296,FALSE
+"H1703","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.20201,0.64,0.943,1765,0.988,"PDGFRA, VEGFD, FLT4, PDGFC, GHR, PDGFB, CCR10, IL17RA, TNFSF12, LIFR, BMPR1A, OSMR, IL13RA1, CCL28, FLT3, CCL2, TNFRSF1A, TGFBR2, XCL1, IFNAR2, IFNGR2, IL6ST",0.0254883072626717,0.00524305541237188,FALSE
+"H1703","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26593,0.857,0.644,4584,0.811,"POLR3C, POLR3G, CHUK, NFKB1, IKBKG, POLR1C, CCL5, RIPK1, POLR3H, POLR3GL, NFKBIB, POLR3A, POLR3K, NFKBIA, IKBKE, IRF3, IL18",0.191114132640188,0.090979145788844,FALSE
+"H1703","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22761,-0.847,0.685,15983,0.759,"ADCY4, TNNT2, CACNA1C, ITGA11, CACNA2D3, CACNG6, RYR2, SLC8A1, TNNI3, ADCY9, CACNA1D, ITGB3, TGFB3, ADCY7, ITGA7, ITGB6, ITGA1, ITGB4, TGFB2, ITGB8, ITGA2",0.164309428507574,0.11975822410452,FALSE
+"H1703","Input","KEGG_DNA_REPLICATION",0.61996,2.01,0.00251,4068,0.141,"MCM5, RNASEH1, RPA1, POLA1, MCM3, POLD2, DNA2, RFC4, POLD1, PRIM2, RFC2, POLE, RNASEH2B, RFC1, LIG1, RNASEH2A, MCM2, POLE2",2.60032627851896,0.85078088734462,TRUE
+"H1703","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.43423,1.41,0.0891,5357,0.468,"SPIRE1, ETS1, CPEB1, GRB2, MAPK1, KRAS, SOS1, NOTCH2, SPIRE2, EGFR, NOTCH3, ETV6, FMN2",1.05012229596313,0.329754146925876,FALSE
+"H1703","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.25836,-0.942,0.516,14488,0.695,"CYP3A7, ADH1C, CYP2A6, GSTA1, GSTM2, UGT2B7, MAOB, CYP3A5, ALDH3B2, GSTM1, ALDH3A1, ALDH1A3, FMO4, AOX1, GSTT2, ALDH3B1, MAOA, MGST1, MGST2",0.287350298372789,0.158015195409886,FALSE
+"H1703","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.19701,0.64,0.951,4066,0.988,"DPYS, HPRT1, UCK2, UPP2, IMPDH2, UMPS, GMPS, UPP1, CYP3A43",0.0218194830625861,0.00524305541237188,FALSE
+"H1703","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43845,-1.64,0.0619,14804,0.501,"CHAD, COL4A1, VWF, RELN, ITGA10, VTN, THBS2, CD36, COL11A1, THBS4, ITGA11, COL4A4, COL3A1, COL6A3, COL4A6, COL4A2, LAMA1, SDC2, HSPG2, COL1A2, ITGB3, SPP1, ITGA7, ITGB6, COL5A1, ITGA1, LAMA4, SV2A, ITGB4, LAMA3, LAMC2, COL6A1, COL1A1, THBS1, FN1, TNC, ITGB8, ITGA2, LAMB3, LAMB1, CD44",1.20830935097988,0.300162274132754,FALSE
+"H1703","Input","KEGG_ENDOCYTOSIS",0.3005,0.978,0.459,4613,0.705,"PDGFRA, VTA1, GIT1, NEDD4, HSPA1L, PLD2, SMAP1, GRK3, PIP4K2B, GRK6, DNM1L, EPN2, NEDD4L, RAB31, PIP5K1A, SMURF2, CBL, RUFY1, SNF8, AP2B1, PDCD6IP, RAB4A, VPS4B, RAB5C, RAB11FIP2, ARRB2, STAM2, HSPA1A, RAB11B, ARFGAP3, RABEP1, IQSEC1, ACAP2, CLTB, AP2A1, ASAP1, SH3KBP1, RAB11FIP3, PARD6A, RBSN, CLTC, PRKCI, VPS36, RAB11A, RET, EPN1, CHMP3, SH3GLB2, CLTCL1, VPS45, PSD, CHMP4A, MVB12B, SH3GLB1, HSPA8, RAB11FIP1, CHMP6, CLTA, EGFR, HGS, FGFR3, HSPA1B",0.338187314462739,0.151810883008601,FALSE
+"H1703","Input","KEGG_ENDOMETRIAL_CANCER",0.36401,1.17,0.209,5062,0.568,"APC2, APC, GRB2, MAPK1, AKT1, KRAS, SOS1, RAF1, CTNNA1, NRAS, MAP2K2, PTEN, MLH1, AKT3, BAD, EGFR, CTNNB1, PIK3CB, AXIN1, AXIN2",0.679853713888946,0.245651664288981,FALSE
+"H1703","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37919,1.21,0.2,2474,0.538,"MAPK11, ATP6V1E2, MAPK12, GIT1, RAC1, MAP3K14, MAPK9, MAPK8, ATP6V1C1, PTPN11, CHUK, CSK, HBEGF, NFKB1, IKBKG, CCL5, JAM3",0.698970004336019,0.269217724333611,FALSE
+"H1703","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.31112,0.987,0.447,2591,0.702,"NRG2, EIF4EBP1, SHC1, PAK2, MAPK9, GRB2, CRKL, MAPK8, CBL, MTOR, MAPK1, CRK, HBEGF, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2",0.349692476868064,0.153662887870195,FALSE
+"H1703","Input","KEGG_ETHER_LIPID_METABOLISM",0.27546,0.896,0.588,2722,0.77,"PLD2, PAFAH1B1, PAFAH1B3, CHPT1, LPCAT1, LPCAT4",0.230622673923862,0.113509274827518,FALSE
+"H1703","Input","KEGG_FATTY_ACID_METABOLISM",0.23773,0.757,0.808,3816,0.906,"ALDH3A2, ECI1, HADHA, ADH5, ACAA2, CPT1A, ACADVL, ALDH9A1, ACAT1, HADHB, ACAT2",0.0925886392254138,0.0428718023231869,FALSE
+"H1703","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.3071,0.982,0.451,3676,0.705,"MAPK11, MAPK12, RAC1, MAPK9, GRB2, MAPK8, MAPK1, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, MAPK14, PRKCA, AKT3, MAP2K3",0.345823458122039,0.151810883008601,FALSE
+"H1703","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.21447,0.694,0.891,3567,0.978,"RAC1, PLD2, PIP4K2B, DNM1L, PIP5K1A, WASF1, CRKL, MAPK1, CRK, ARPC1B, VASP, AKT1, RAF1, RPS6KB1, WASF2, ASAP1, ARPC5, PRKCA, AKT3",0.0501222959631252,0.00966114521239857,FALSE
+"H1703","Input","KEGG_FOCAL_ADHESION",0.25566,0.823,0.707,2361,0.831,"PDGFRA, LAMC3, VEGFD, FLT4, PDGFC, CCND2, PDGFB, RAC1, SHC1, PAK2, MAPK9, COL5A2, MYL12B, VCL, ROCK1, BIRC3, GRB2, CRKL, MAPK8, BIRC2, TLN1, MAPK1, CRK, LAMB2, RAPGEF1, VASP, AKT1, XIAP, SOS1, RAF1, CAV2",0.150580586203101,0.080398976215889,FALSE
+"H1703","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.40759,-1.54,0.0553,15242,0.366,"ALPG, PTS, ALPP, QDPR",1.2572748686953,0.436518914605589,FALSE
+"H1703","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.22928,-0.807,0.709,16156,0.814,"FBP1, AKR1B10, PFKFB4, MTMR7, MPI, HK2, ALDOC",0.149353764816933,0.0893755951107988,FALSE
+"H1703","Input","KEGG_GALACTOSE_METABOLISM",-0.24419,-0.896,0.539,16354,0.72,"GCK, GLB1, B4GALT1, GALE, HK2, GAA",0.268411234813261,0.142667503568732,FALSE
+"H1703","Input","KEGG_GAP_JUNCTION",0.32643,1.04,0.356,3882,0.653,"PDGFRA, PDGFC, PDGFB, ITPR2, TUBB3, GRB2, PLCB3, PLCB4, ADCY3, MAPK1, TUBB4A, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKACA, TUBB6, CSNK1D, PRKCA, TUBB, GNA11, TUBB2B, TUBB2A, GNAI2",0.448550002027125,0.185086818724926,FALSE
+"H1703","Input","KEGG_GLIOMA",0.38173,1.23,0.171,3587,0.62,"PDGFRA, PDGFB, SHC1, GRB2, E2F2, MTOR, CALML6, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PTEN, PRKCA, AKT3, CALM3",0.767003889607846,0.207608310501746,FALSE
+"H1703","Input","KEGG_GLUTATHIONE_METABOLISM",-0.30408,-1.07,0.355,16922,0.648,"GPX2, ANPEP, GPX3, GPX7, GSTT2, RRM1, GGT7, MGST1, MGST2, GPX1",0.449771646944906,0.188424994129407,FALSE
+"H1703","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.27729,-1.04,0.364,18253,0.634,"DGKG, LIPG, GK, ALDH2, DGKA, PLPP3, MGLL",0.438898616350944,0.197910742118267,FALSE
+"H1703","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.27262,0.888,0.608,4530,0.778,"PLD2, PEMT, GNPAT, AGPAT1, LPCAT3, LCLAT1, LPGAT1, CHPT1, DGKZ, ETNK1, LPCAT1, LPCAT4, ETNK2, PTDSS1, MBOAT2, DGKH, ACHE, PCYT1A, PGS1, GPAT3, DGKQ, AGPAT4",0.216096420727265,0.109020403010311,FALSE
+"H1703","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.38859,1.26,0.168,4438,0.579,"AOC2, AOC3, CBS, PSAT1, GCAT, PHGDH, PSPH, SRR, AMT, ALAS1",0.774690718274137,0.237321436272564,FALSE
+"H1703","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.27207,-0.982,0.437,16071,0.675,"LDHC, ALDH3B2, FBP1, GCK, AKR1A1, ALDH3A1, LDHAL6B, ALDH1A3, LDHA, ALDH3B1, HK2, ACSS1, ALDOC, ALDH2, GALM, ACSS2, ENO2",0.359518563029578,0.170696227168975,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.28899,0.944,0.514,2370,0.739,"CHST7, CHST13, CSGALNACT2, CHST3, B3GAT1",0.289036881004724,0.131355561605174,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.36305,-1.36,0.123,14466,0.565,"EXTL1, HS6ST3, HS6ST1, HS3ST5, NDST3, GLCE, EXT1, HS3ST3B1, HS3ST1, B3GALT6, EXTL3, EXTL2, EXT2",0.910094888560602,0.247951552180562,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.55485,-2.02,0.0206,17207,0.256,"B3GNT7, B4GALT1, CHST6, B4GALT3, ST3GAL1, B4GAT1, B4GALT4",1.68613277963085,0.59176003468815,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.35272,-1.31,0.115,14399,0.544,"HYAL1, GNS, HEXA, GLB1, HGSNAT, HS3ST3B1, HPSE, NAGLU",0.939302159646388,0.26440110030182,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.36302,-1.32,0.116,15441,0.56,"HEXA, SLC33A1, ST6GALNAC3, GLB1, ST8SIA1, ST6GALNAC5, ST3GAL1, ST3GAL5",0.935542010773082,0.2518119729938,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.44206,-1.61,0.0435,16571,0.403,"FUT2, ST8SIA1, B3GALT5, GBGT1, ST3GAL1, FUT1, B3GALNT1",1.36151074304536,0.39469495385889,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.55655,-2.07,0.0104,14036,0.415,"FUT9, B3GALT2, FUT7, ST3GAL6, B3GALT1, ABO, FUT2, FUT3, ST8SIA1, B3GALT5, B4GALT1, B4GALT3, B3GNT3, FUT1, B4GAT1, B4GALT4, B3GNT5",1.98296666070122,0.381951903287907,FALSE
+"H1703","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.28154,-1.04,0.341,17741,0.634,"PIGM, PGAP1, PIGP, PIGH",0.467245621007502,0.197910742118267,FALSE
+"H1703","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.47917,1.54,0.045,4607,0.435,"MTHFD1L, ACO2, MTHFD2, PGP, MTHFD1, GRHPR",1.34678748622466,0.361510743045363,FALSE
+"H1703","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.34007,1.08,0.335,3676,0.628,"MAPK11, MAPK12, ITPR2, PLD2, MAPK9, GRB2, GNRH2, MAPK8, PLCB3, CALML6, PLCB4, ADCY3, MAPK1, HBEGF, MAP3K4, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKACA, MAPK14, ATF4, PRKCA, CALM3, GNA11, MAP2K3",0.474955192963155,0.202040356262804,FALSE
+"H1703","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.50601,-1.84,0.00505,9878,0.373,"KLRD1, IFNG, KIR2DL1, CD28, KIR3DL2, IL2, KIR3DL1, KIR2DL3, FASLG, CD80, PRF1, TNF, FAS, CD86, GZMB, IL1A, IL6, IL1B",2.29670862188134,0.428291168191312,FALSE
+"H1703","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.33871,1.09,0.315,4313,0.614,"GLI1, BTRC, WNT5B, BMP6, RAB23, FBXW11, PTCH2, CSNK1A1, WNT6, PRKACA, BMP7, CSNK1D, CSNK1G3, ZIC2, CSNK1E, STK36, BMP8A, WNT2B",0.501689446210399,0.211831628858832,FALSE
+"H1703","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.35053,-1.28,0.152,15494,0.572,"KIT, CSF1R, CD36, FCGR1A, KITLG, CSF2, CD22, CD4, IL1A, IL6, IL1B, IL1R2, ANPEP, CD14, CSF2RA, ITGB3, IL11, ITGA1, IL6R, CD55, CD59, ITGA2, FLT3LG, CD44",0.818156412055227,0.242603971206976,FALSE
+"H1703","Input","KEGG_HISTIDINE_METABOLISM",-0.2891,-1.08,0.276,14856,0.648,"ACY3, AOC1, DDC, HEMK1, MAOB, ALDH3B2, ALDH3A1, ALDH1A3, LCMT2, ALDH3B1, MAOA, HNMT, ALDH2",0.559090917934782,0.188424994129407,FALSE
+"H1703","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.58066,1.86,0.00719,6162,0.21,"RPA1, RAD52, POLD2, RAD50, POLD1, RAD51, MUS81, MRE11, RAD54L, XRCC3, RAD51D, BRCA2, NBN, XRCC2, RAD54B, BLM, TOP3B, SEM1, EME1, RAD51C, POLD3",2.14327110961712,0.677780705266081,TRUE
+"H1703","Input","KEGG_HUNTINGTONS_DISEASE",0.32908,1.07,0.332,4251,0.613,"GRIN2B, NDUFS6, SDHA, NDUFA9, TBP, DLG4, TFAM, NDUFA1, ATP5F1A, VDAC2, TAF4B, COX7A2L, PPID, HIP1, POLR2J, PLCB3, EP300, AP2B1, PLCB4, TBPL1, NDUFS4, VDAC1, NDUFA3, POLR2E, SLC25A5, HDAC2, CYCS, SIN3A, CYC1, ATP5F1D, POLR2H, SDHB, POLR2F, TGM2, CLTB, AP2A1, POLR2B, NDUFS3, POLR2J2, SP1, NDUFA6, BAX, SOD2, NDUFA10, CLTC, NDUFB8, ATP5F1C, UQCRHL, CLTCL1, UQCRFS1, NDUFC1, DCTN1, POLR2A",0.478861916295964,0.212539525481585,FALSE
+"H1703","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.24638,-0.872,0.643,16198,0.76,"TNNT2, CACNA1C, ITGA11, CACNA2D3, CACNG6, RYR2, PRKAB1, SLC8A1, TNNI3, IL6, CACNA1D, ITGB3, ACE, TGFB3, ITGA7, ITGB6, ITGA1, ITGB4, TGFB2, ITGB8, ITGA2",0.191789027075778,0.119186407719209,FALSE
+"H1703","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.36842,1.19,0.227,4909,0.558,"OCRL, PIP4K2B, IMPA1, PIP5K1A, INPP5B, TPI1, PLCE1, PI4KB, PLCB3, PLCB4, INPP4B, PLCD4, PTEN, PIK3C3, INPP5J, ISYNA1, INPPL1, PLCG2, INPP5E, PIK3CB, IPMK",0.643974142806877,0.253365801062421,FALSE
+"H1703","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.34774,1.12,0.275,5499,0.586,"EIF4EBP1, SHC1, MAPK9, SOCS3, PRKAG2, PRKAA1, PHKA1, GRB2, PRKAR2A, CRKL, MAPK8, CBL, MTOR, FLOT1, CALML6, MAPK1, CRK, PRKAR2B, HK3, RAPGEF1, AKT1, KRAS, SOS1, RAF1, NRAS, RHOQ, ACACA, MAP2K2, PCK2, PRKACA, SOCS2, PHKA2, RPS6KB1, FLOT2, MKNK2, TRIP10, AKT3, CALM3, PRKCI, SREBF1, PPP1CC, BAD, EXOC7, FASN, PIK3CB, G6PC2, PRKAR1B, PDE3B, IKBKB, PYGL, RPTOR, TSC2, CALM1, ACACB, SH2B2, PRKAR1A, PRKCZ",0.560667306169737,0.232102383981909,FALSE
+"H1703","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.29937,0.954,0.521,2595,0.734,"CCR10, MAP3K14, CCL28, CD40, MADCAM1",0.283162276700476,0.134303940083929,FALSE
+"H1703","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.28043,0.902,0.587,2964,0.774,"CCND2, GHR, STAT3, PIAS3, LIFR, SOCS3, OSMR, IL13RA1, GRB2, CBL, PTPN11, EP300, IFNAR2, IFNGR2, IL6ST, SOCS7, PIAS2, LIF, TYK2, AKT1, SOS1, STAM2, SPRY3, SPRY4, IFNW1, SOCS2, LEPR",0.231361898752386,0.111259039317107,FALSE
+"H1703","Input","KEGG_LEISHMANIA_INFECTION",0.29456,0.942,0.51,4257,0.735,"MAPK11, MAPK12, ITGAM, MAP3K7, IFNGR2, MAPK1, NFKB1, TAB1, IRAK1, MAPK14, JAK1, FOS, NFKBIB, TAB2, TGFB1, MYD88, NFKBIA",0.292429823902064,0.133712660915805,FALSE
+"H1703","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.19966,0.64,0.938,4070,0.988,"MAPK11, MAPK12, RAC1, ITGAM, MYL12B, VCL, ROCK1, THY1, PTPN11, VASP, OCLN, CTNNA1, JAM3, AFDN, CLDN15, MAPK14, MYL12A, RHOA, PRKCA, PXN, MSN, GNAI2, BCAR1, SIPA1",0.0277971616209356,0.00524305541237188,FALSE
+"H1703","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.39056,1.25,0.168,4604,0.586,"ALDH3A2, HADHA, ALDH9A1, ALDH1B1",0.774690718274137,0.232102383981909,FALSE
+"H1703","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.27636,-1.03,0.353,11712,0.621,"CYP1A2, PLA2G2A, PLA2G5, PLA2G2C, CYP2E1, PLA2G2F, PLA2G4B, ALOX15, PLA2G4E, PLA2G6, CYP3A7, PLA2G3, CYP2J2, PLA2G10, CYP3A5, AKR1B10, PLA2G4A",0.452225294612177,0.20690839982342,FALSE
+"H1703","Input","KEGG_LONG_TERM_DEPRESSION",0.28316,0.912,0.567,2591,0.769,"CACNA1A, ITPR2, PPP2CA, GNA13, PLCB3, PLCB4, MAPK1, GNAZ, KRAS, RAF1, NRAS, MAP2K2",0.246416941107093,0.114073660198569,FALSE
+"H1703","Input","KEGG_LONG_TERM_POTENTIATION",0.35671,1.16,0.23,3587,0.58,"GRIN2B, ITPR2, RPS6KA6, PLCB3, EP300, CALML6, PLCB4, MAPK1, KRAS, PPP3R2, RAF1, NRAS, MAP2K2, PPP3CB, PRKACA, ATF4, PRKCA, CALM3",0.638272163982407,0.236572006437063,FALSE
+"H1703","Input","KEGG_LYSINE_DEGRADATION",0.3071,0.998,0.437,4958,0.687,"NSD3, ALDH3A2, HADHA, SETD2, NSD2, NSD1, TMLHE, SETDB2, ALDH9A1, OGDH, ACAT1, ACAT2, EHMT2, ALDH1B1, KMT5A, DOT1L",0.359518563029578,0.16304326294045,FALSE
+"H1703","Input","KEGG_LYSOSOME",-0.28575,-1.1,0.312,15828,0.627,"ATP6V0B, ATP6V0D1, GBA, SCARB2, ATP6V0A4, ABCB9, SORT1, LAPTM5, ACP5, GLB1, PLA2G15, HGSNAT, SLC11A2, CTSC, CTSB, CTSS, ATP6V1H, NEU1, AP1S3, NAGLU, CTSD, NPC2, CD63, GAA, FUCA1, ENTPD4, AP1M2, TPP1, MANBA, AP3S2, SMPD1, CTSH, ASAH1, CTSZ",0.505845405981557,0.202732459169284,FALSE
+"H1703","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.39106,1.27,0.158,3426,0.59,"PDGFRA, MAPK11, CACNA1A, FGF17, MAP3K20, PDGFB, NFKB2, MAPK12, RAC1, MEF2C, MAP3K14, RPS6KA6, MAPK8IP2, PAK2, CACNB1, HSPA1L, MAPK9, RELB, SRF, FGF2, FGF5, CACNA1G, FGFR1, MAP3K12, PPM1B, MAP3K7, DAXX, GRB2, ELK4, HSPB1, CRKL, MAPK8, TNFRSF1A, TGFBR2, FGF12, DUSP16, CHUK, CACNA1H, MAPK1, CRK, RPS6KA4, NFKB1, IKBKG, MAP3K4, CDC25B, TAB1, MAP4K2, AKT1, TAOK1, KRAS, FGF8, PPP3R2, SOS1, RAF1, NRAS, STK3, CACNA1B, ARRB2, MAP2K2, RRAS, HSPA1A, PPP3CB, MRAS, MAPK8IP1, PRKACA, NF1, MAPK14, NLK, MKNK2, ATF4, MAP3K6, FOS, PRKCA, CACNB4",0.801342913045577,0.229147988357856,FALSE
+"H1703","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.37293,-1.39,0.0978,14279,0.543,"NR5A2, HNF4A, ONECUT1, FOXA3, HNF1B, BHLHA15, GCK, HNF4G, FOXA2, PAX6, HES1",1.0096611452124,0.265200170411153,FALSE
+"H1703","Input","KEGG_MELANOGENESIS",-0.20407,-0.76,0.839,15276,0.86,"EDNRB, CAMK2B, CAMK2A, KIT, TYRP1, WNT7B, WNT7A, ADCY4, KITLG, WNT10A, TCF7L2, WNT11, WNT3, ADCY9, CREB3L4, LEF1, ADCY7, FZD9, MITF, FZD4, CREB3L1, FZD8, PLCB2, WNT5A, FZD7, EDN1, HRAS, PLCB1, CREB3L2, FZD3",0.0762380391712997,0.0655015487564323,FALSE
+"H1703","Input","KEGG_MELANOMA",0.42035,1.35,0.106,2759,0.514,"PDGFRA, FGF17, PDGFC, PDGFB, FGF2, FGF5, FGFR1, E2F2, FGF12, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, FGF8, RAF1, NRAS, MAP2K2, PTEN",0.97469413473523,0.289036881004724,FALSE
+"H1703","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.31784,-1.19,0.243,14488,0.554,"CYP3A7, ADH1C, GSTA1, DHDH, GSTM2, UGT2B7, CYP3A5, ALDH3B2, AKR1C1, GSTM1, ALDH3A1, ALDH1A3, AKR1C2, CYP1B1, GSTT2, AKR1C3, ALDH3B1, CYP1A1, CYP2S1, MGST1, MGST2",0.614393726401688,0.25649023527157,FALSE
+"H1703","Input","KEGG_MISMATCH_REPAIR",0.66301,2.13,0.00513,4127,0.179,"PMS2, RPA1, POLD2, MSH6, RFC4, POLD1, MSH2, RFC2, EXO1, MLH1, RFC1, LIG1, MSH3",2.28988263488818,0.747146969020107,TRUE
+"H1703","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.39377,1.27,0.146,3567,0.59,"VEGFD, EIF4EBP1, RPS6KA6, PRKAA1, STK11, ULK2, MTOR, MAPK1, AKT1, ULK1, RPS6KB1, MLST8, RICTOR, AKT3",0.835647144215563,0.229147988357856,FALSE
+"H1703","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.28633,0.911,0.572,2705,0.763,"KLRK1, NFATC1, RAC1, KLRC2, SHC1, KLRC3, MICA, GRB2, PTPN11, IFNAR2, IFNGR2, MAPK1, MICB, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, BID, PPP3CB",0.242603971206976,0.11747546204512,FALSE
+"H1703","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.26553,0.863,0.644,1739,0.807,"GRIN2B, GRIN3B, S1PR1, GABRD, TBXA2R, CHRM4, GHR, C5AR1, AVPR2, P2RY4, GABRQ, S1PR5, GHSR, MC5R, ADORA2A, HRH1, LPAR2, GABRR2, TRHR, TRPV1, PTGER4, CRHR2, GRM6, GABBR1, CHRNA5",0.191114132640188,0.0931264652779296,FALSE
+"H1703","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.35215,1.13,0.275,5783,0.604,"MAPK11, MAPK12, RAC1, SHC1, RPS6KA6, MAPK9, NFKBIE, YWHAH, GRB2, CRKL, MAPK8, PTPN11, CALML6, CSK, MAPK1, CRK, RPS6KA4, NFKB1, RAPGEF1, AKT1, KRAS, YWHAE, SOS1, RAF1, NRAS, IRAK1, MAP2K2, MAPK14, RHOA, ATF4, AKT3, CALM3, BAX, NFKBIB, YWHAQ, RIPK2, NFKBIA, PLCG2, BAD, CAMK2G, MAPK7, PIK3CB, IRAK2, IKBKB, ZNF274, YWHAG, CALM1, SH2B2, NTF4, CDC42, KIDINS220, ABL1, BEX3",0.560667306169737,0.218963061378868,FALSE
+"H1703","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.23279,-0.869,0.596,14031,0.751,"QPRT, ENPP3, ENPP1, BST1, NMNAT2, AOX1, NMNAT3, NNT",0.224753740259764,0.124360062995832,FALSE
+"H1703","Input","KEGG_NITROGEN_METABOLISM",-0.27506,-1.02,0.386,17266,0.609,"CA9, GLS2, CA12, CPS1, CTH",0.413412695328245,0.215382707367125,FALSE
+"H1703","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.41774,1.33,0.11,3992,0.541,"NLRC4, MAPK11, MAPK12, MAPK9, HSP90AB1, ERBIN, BIRC3, MAP3K7, MAPK8, CCL2, BIRC2, CHUK, MAPK1, NFKB1, IKBKG, TAB1, XIAP, CCL5, MAPK14, SUGT1, NFKBIB, NAIP, TAB2, RIPK2",0.958607314841775,0.266802734893431,FALSE
+"H1703","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.62191,2.03,0.00362,4017,0.182,"XRCC6, RAD50, PRKDC, MRE11, POLL, XRCC4, LIG4",2.44129142946683,0.739928612014925,TRUE
+"H1703","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.31299,1,0.443,4830,0.691,"GRB2, E2F2, MAPK1, E2F3, E2F1, CDKN2A, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PRKCA, AKT3, RB1, PLCG2, BAD, EGFR, PIK3CB",0.35359627377693,0.160521952625802,FALSE
+"H1703","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.31269,1.01,0.406,4661,0.677,"APH1A, NUMBL, EP300, KAT2A, HDAC2, CTBP1, KAT2B, NOTCH2, DVL1, DVL2, MAML1, JAG2, ADAM17, NCOR2, CTBP2, DLL3, PSEN2, DVL3, CREBBP, NOTCH3, MFNG",0.391473966422806,0.169411331314856,FALSE
+"H1703","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.43379,1.4,0.0916,6239,0.449,"GTF2H5, RPA1, GTF2H2, CUL4A, POLD2, RFC4, POLD1, RFC2, POLE, CUL4B, RFC1, LIG1, POLE2, ERCC2, ERCC8, CETN2, RBX1, RAD23A, CDK7, POLD3, ERCC1",1.03810452633215,0.347753658996677,FALSE
+"H1703","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.26286,-0.949,0.459,17042,0.714,"ALG9, RPN2, B4GALT1, B4GALT3, MAN1C1, ALG10B, MAN1B1, MOGS, MAN1A1, DOLPP1",0.338187314462739,0.146301788223826,FALSE
+"H1703","Input","KEGG_OLFACTORY_TRANSDUCTION",0.23183,0.742,0.817,700,0.921,"OR4A47, OR2V2, OR4S1, GNAL, OR2H2, OR2A5, GRK3, OR4F16",0.0877779434675845,0.0357403698031511,FALSE
+"H1703","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.53985,1.74,0.0215,2373,0.292,"FTCD, MTHFD1L, ATIC, TYMS, GART, MTHFD2",1.66756154008439,0.534617148551582,FALSE
+"H1703","Input","KEGG_OOCYTE_MEIOSIS",0.4335,1.4,0.0889,4685,0.449,"PPP2R5A, MAPK12, ITPR2, BTRC, RPS6KA6, PPP2CA, CPEB1, MAD2L2, YWHAH, ESPL1, FBXW11, FBXO43, CALML6, PPP2R5D, ADCY3, MAPK1, SLK, SGO1, PPP3R2, YWHAE, CDC20, CCNB1, PPP3CB, PRKACA, SMC1B, CDC27, PTTG2, PPP2R5E, ANAPC1, ANAPC7, ANAPC4, PKMYT1, CDC23, CALM3, YWHAQ, FBXO5, PLK1, PPP1CC, BUB1, CCNE2, SMC3, CAMK2G, SMC1A",1.05109823902979,0.347753658996677,FALSE
+"H1703","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.4118,-1.55,0.0508,15441,0.388,"HEXA, GBA, GLB1, NEU1, FUCA1, MANBA",1.29413628771608,0.411168274405793,FALSE
+"H1703","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.21251,0.684,0.924,4989,0.972,"ATP6V1E2, NDUFS6, SDHA, NDUFA9, NDUFA1, ATP5F1A, COX7A2L, ATP6V1C1, NDUFS4, COX15, NDUFA3, CYC1, COX10, ATP5F1D, SDHB, COX11, NDUFS3, NDUFA6, NDUFA10, NDUFB8, ATP5F1C, UQCRHL, UQCRFS1, NDUFC1, TCIRG1, ATP6V0A1, COX7C, ATP5PD, UQCRC1",0.0343280287798933,0.0123337350737254,FALSE
+"H1703","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.33721,1.09,0.317,301,0.614,"GALNT8, GALNT13",0.498940737782249,0.211831628858832,FALSE
+"H1703","Input","KEGG_P53_SIGNALING_PATHWAY",0.34936,1.14,0.257,5416,0.604,"CCNB3, ADGRB1, CCND2, CHEK2, SHISA5, TP53I3, EI24, CDKN2A, SERPINE1, CYCS, GTSE1, CCNB1, BID, PTEN, SESN2, RRM2, COP1, CHEK1, RRM2B, BAX, SIAH1, IGFBP3, ATM, CCNE2, STEAP3, GADD45B, CDK2, CCND3, TSC2, ATR",0.590066876668705,0.218963061378868,FALSE
+"H1703","Input","KEGG_PANCREATIC_CANCER",0.4332,1.39,0.0847,2400,0.449,"VEGFD, RAC1, SMAD2, STAT3, MAPK9, RALBP1, E2F2, MAPK8, TGFBR2, CHUK, MAPK1, E2F3, NFKB1, E2F1, RAD51, IKBKG, CDKN2A, AKT1, KRAS, RAF1, SMAD4",1.07211658966929,0.347753658996677,FALSE
+"H1703","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.18878,-0.714,0.905,14406,0.888,"ENPP3, VNN1, ENPP1, VNN2, DPYD, BCAT1",0.0433514207947967,0.051587034221399,FALSE
+"H1703","Input","KEGG_PARKINSONS_DISEASE",0.2881,0.931,0.537,5778,0.734,"NDUFS6, UBE2G1, SDHA, NDUFA9, NDUFA1, ATP5F1A, VDAC2, COX7A2L, PPID, UBE2J1, UCHL1, NDUFS4, VDAC1, NDUFA3, SLC25A5, CYCS, CYC1, ATP5F1D, SDHB, NDUFS3, NDUFA6, NDUFA10, NDUFB8, ATP5F1C, UBE2J2, UBE2L3, UQCRHL, UQCRFS1, NDUFC1, UBE2G2, COX7C, ATP5PD, UQCRC1, UBB, UQCR11, NDUFV3, COX6C, VDAC3, UQCRB, ATP5MC1, NDUFAB1",0.270025714300444,0.134303940083929,FALSE
+"H1703","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.25677,0.825,0.685,6351,0.835,"ROCK1, TUBB3, ARPC1B, TUBB4A, OCLN, NCL, TUBB6, RHOA, ARPC5, PRKCA, TUBB, TUBB2B, YWHAQ, TUBB2A, ARPC1A, CTNNB1, ROCK2, ACTB, CDC42, CLDN1, ABL1, TUBA1A, ITGB1, ARPC5L, YWHAZ",0.164309428507574,0.0783135245163979,FALSE
+"H1703","Input","KEGG_PATHWAYS_IN_CANCER",0.29938,0.977,0.465,4615,0.698,"PDGFRA, LAMC3, FGF17, VEGFD, APC2, GLI1, PDGFB, NFKB2, RAC1, SMAD2, STAT3, WNT5B, PIAS3, ARNT, MAPK9, HSP90AB1, ETS1, RALBP1, FGF2, FGF5, FGFR1, BIRC3, TRAF3, APC, GRB2, FLT3, E2F2, CRKL, MAPK8, CBL, MTOR, EGLN1, BIRC2, PTCH2, TGFBR2, EP300, FGF12, VHL, CHUK, MAPK1, CRK, MSH6, E2F3, NFKB1, CCDC6, LAMB2, E2F1, RAD51, IKBKG, PIAS2, CDKN2A, TPM3, AKT1, XIAP, KRAS, FGF8, HDAC2, SOS1, MSH2, RAF1, CTNNA1, CTBP1, NRAS, SMAD4, CYCS, MAP2K2, BID, DVL1, PTEN, DVL2, WNT6, MLH1, RHOA, BRCA2, JAK1, FOS, PRKCA, AKT3, BAX, TRAF1, TRAF5, RB1, LAMA5, TGFB1, CTBP2, RET, STK36, MSH3, DAPK3, TRAF2, NFKBIA, WNT2B, DVL3, PLCG2, ELOC, BAD, CUL2, CREBBP, CCNE2, EGFR, SMAD3, CTNNB1, FGFR3, EGLN2",0.332547047110046,0.156144577376839,FALSE
+"H1703","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.19084,-0.677,0.868,11600,0.92,"UGT2B4, UGT2B17, UGT2A3, UGT2A1, UGT2B15, UGP2, DHDH, UGT2B7, DCXR, UGDH",0.0614802748235081,0.0362121726544447,FALSE
+"H1703","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.27662,-1.03,0.361,17989,0.621,"H6PD, ALDOC, TALDO1",0.442492798094342,0.20690839982342,FALSE
+"H1703","Input","KEGG_PEROXISOME",0.21494,0.691,0.886,4109,0.973,"PEX5, PEX16, HACL1, SLC25A17, DECR2, GNPAT, PEX26, AMACR, MPV17, PHYH, PEX6, PEX3, PXMP2, ABCD2, SOD2, PXMP4, AGPS, CRAT",0.0525662781129492,0.0118871597316481,FALSE
+"H1703","Input","KEGG_PHENYLALANINE_METABOLISM",0.37676,1.21,0.202,1522,0.538,"AOC2, AOC3, GOT1",0.694648630553376,0.269217724333611,FALSE
+"H1703","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.34267,1.12,0.286,4486,0.586,"OCRL, ITPR2, PIP4K2B, IMPA1, PIP5K1A, INPP5B, PLCE1, PI4KB, PLCB3, CALML6, PLCB4, DGKZ, INPP4B, PLCD4, PTEN, PIK3C3, INPP5J, PRKCA, CALM3, INPPL1, DGKH, PLCG2, INPP5E, DGKQ",0.543633966870957,0.232102383981909,FALSE
+"H1703","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.3162,1.03,0.411,3089,0.649,"HMOX1, FECH, COX15, COX10, FTH1",0.386158178123931,0.187755303199631,FALSE
+"H1703","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.3797,-1.34,0.147,13054,0.559,"CYP8B1, CYP7A1, PCK1, APOA1, CPT1B, FABP1, ACSL1, HMGCS2, RXRG, ACSL6, FABP4, CYP4A22, DBI, APOA2, SLC27A6, ACSL3, FABP7, AQP7, EHHADH, ACOX1, LPL, PPARA, OLR1, SORBS1, ACADL, CD36, CYP27A1, FABP3, FADS2, SCP2, ILK, ACOX2, FABP6, ACSL5, CPT1C, SLC27A2, CPT2, GK, PLTP, ME1",0.832682665251824,0.252588192113577,FALSE
+"H1703","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.32686,-1.21,0.194,16280,0.562,"CYP7B1, CYP27A1, SCP2, CYP39A1, ACOX2",0.712198270069774,0.250263684430939,FALSE
+"H1703","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.37858,1.22,0.2,3722,0.567,"TAP2, RFX5, TAP1, IKBKG, ADA, UNG, CD40, RFXANK, RFXAP",0.698970004336019,0.246416941107093,FALSE
+"H1703","Input","KEGG_PRION_DISEASES",0.1923,0.619,0.975,3665,0.994,"MAPK1, CCL5, MAP2K2, HSPA1A, PRKACA, BAX",0.0109953843014632,0.00261361560268669,FALSE
+"H1703","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.45689,1.5,0.0456,3567,0.401,"CCNB3, MAPK11, MAPK12, RPS6KA6, MAPK9, HSP90AB1, CPEB1, MAD2L2, MAPK8, ADCY3, MAPK1, CDC25B, AKT1, KRAS, RAF1, CDC25A, CCNB1, PRKACA, CDC27, MAPK14, ANAPC1, ANAPC7, CCNA2, ANAPC4, FZR1, PKMYT1, CDC23, AKT3",1.34103515733556,0.396855627379818,FALSE
+"H1703","Input","KEGG_PROPANOATE_METABOLISM",-0.39651,-1.4,0.103,16714,0.569,"HIBCH, LDHAL6B, ACSS3, LDHA, ABAT, ACSS1, MLYCD, ALDH2, MCEE, ACSS2, ALDH6A1",0.987162775294828,0.244887733604929,FALSE
+"H1703","Input","KEGG_PROSTATE_CANCER",0.3573,1.15,0.249,2759,0.592,"PDGFRA, PDGFC, PDGFB, HSP90AB1, SRD5A2, FGFR1, GRB2, E2F2, MTOR, EP300, CHUK, MAPK1, E2F3, NFKB1, E2F1, IKBKG, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2, PTEN",0.603800652904264,0.22767829327708,FALSE
+"H1703","Input","KEGG_PROTEASOME",0.38944,1.27,0.162,5852,0.59,"PSMD4, PSMB4, PSMB9, PSME3, PSMC5, PSMD12, PSMF1, PSMD1, PSMA2, PSMD14, PSMD3, PSMB10, PSMD11, PSMD2, PSMA5, PSMB8, PSMA4, PSMC2, PSMB1, SEM1, PSME2",0.790484985457369,0.229147988357856,FALSE
+"H1703","Input","KEGG_PROTEIN_EXPORT",0.37758,1.21,0.187,3938,0.538,"SEC63, SRP19, SRP9, SRP72, SEC61A2, SEC11C, SRP68, SRPRB",0.728158393463501,0.269217724333611,FALSE
+"H1703","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.14865,0.485,0.997,4853,0.998,"PCK2, ATP1A3, GLUD1, SLC25A10, SLC9A3",0.00130484168834428,0.000869458712628891,FALSE
+"H1703","Input","KEGG_PURINE_METABOLISM",0.36229,1.17,0.251,4293,0.568,"PDE4A, NT5C2, POLR3C, PFAS, ADSL, POLR3G, ADK, PRPS1, PDE6C, POLA1, ATIC, HPRT1, NME4, NME2, ENTPD8, POLR1E, POLD2, POLR2J, GART, ADCY3, POLD1, NME1, POLR1C, ADA, POLR2E, NUDT5, PRUNE1, PRIM2, AMPD2, NME6, POLR3H, IMPDH2, GUK1, POLR2H, POLR2F, RRM2, PDE9A, GMPS, POLE, ENTPD1, POLR2B, POLR2J2, DCK, POLR3GL, RRM2B, PDE10A, PAICS, POLR3A, POLR3K, POLE2, PAPSS2, NUDT2, POLR2A, NME3",0.600326278518962,0.245651664288981,FALSE
+"H1703","Input","KEGG_PYRIMIDINE_METABOLISM",0.50444,1.62,0.0286,4293,0.423,"NT5C2, TXNRD1, POLR3C, POLR3G, CAD, POLA1, CTPS1, DPYS, NME4, NME2, TYMS, ENTPD8, POLR1E, POLD2, POLR2J, UCK2, POLD1, NME1, POLR1C, UPP2, POLR2E, PRIM2, NME6, POLR3H, UMPS, POLR2H, POLR2F, RRM2, DCTD, DUT, POLE, UPRT, ENTPD1, POLR2B, POLR2J2, DCK, POLR3GL, RRM2B, POLR3A, UPP1, POLR3K, POLE2, NUDT2, POLR2A, NME3",1.54363396687096,0.373659632624958,FALSE
+"H1703","Input","KEGG_PYRUVATE_METABOLISM",-0.27456,-1.05,0.35,18483,0.649,"ACSS1, ALDH2, ACSS2, ME1, PC",0.455931955649724,0.187755303199631,FALSE
+"H1703","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.34257,1.1,0.308,3352,0.611,"PDGFRA, FGF17, APC2, PDGFC, CHRM4, PDGFB, GIT1, RAC1, ITGAM, PFN1, PAK2, PFN4, ENAH, MYL12B, PIP4K2B, VCL, ROCK1, FGF2, FGF5, SSH1, FGFR1, PIP5K1A, WASF1, APC, GNA13, CRKL, FGF12, TMSB4Y, CSK, MAPK1, CRK, CYFIP1, ARPC1B, KRAS, FGF8, SOS1, RAF1, NRAS, MYH9, MAP2K2, RRAS, MRAS, FGD1, DIAPH3, IQGAP1, WASF2, MYL12A, DOCK1, RHOA, ARPC5",0.511449283499556,0.213958789757446,FALSE
+"H1703","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.45818,1.47,0.0627,3091,0.413,"ATG5, ATG7, PRKAA1, ULK2, ULK1, GABARAPL1, BECN1, PIK3C3",1.20273245916928,0.384049948343599,FALSE
+"H1703","Input","KEGG_RENAL_CELL_CARCINOMA",0.39768,1.29,0.148,2591,0.598,"VEGFD, PDGFB, RAC1, ARNT, PAK2, ETS1, GRB2, CRKL, EGLN1, PTPN11, EP300, VHL, MAPK1, CRK, RAPGEF1, AKT1, KRAS, SOS1, RAF1, NRAS, MAP2K2",0.829738284605043,0.223298816011589,FALSE
+"H1703","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32245,1.04,0.365,1261,0.653,"NLN, LNPEP",0.437707135543525,0.185086818724926,FALSE
+"H1703","Input","KEGG_RETINOL_METABOLISM",-0.22451,-0.797,0.668,11025,0.82,"UGT2B11, CYP4A11, DHRS4L2, ADH6, CYP2A13, ADH1B, RDH8, UGT2B4, ADH7, UGT2B17, CYP1A2, ADH1A, UGT2A3, AWAT2, UGT2A1, UGT2B15, CYP2A7, RDH10, CYP2B6, RPE65, CYP4A22, CYP3A7, ADH1C, CYP2A6, RDH16, RDH5, UGT2B7, RETSAT, DHRS9, CYP3A5, BCO1, LRAT, ALDH1A2, CYP1A1, CYP26B1, RDH11, DHRS3",0.175223537524454,0.0861861476162833,FALSE
+"H1703","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.20606,-0.721,0.827,3935,0.908,"MTMR1, ACP6, MTMR6, RFK, ACP1, FLAD1, ACP2, ACP4, PHPT1, MTMR2, TYR, ENPP3, ENPP1, ACP5, MTMR7",0.0824944904474534,0.0419141514789149,FALSE
+"H1703","Input","KEGG_RIBOSOME",-0.25121,-0.929,0.527,15661,0.678,"RPS8, RPL10A, RPL18, RPL7A, RPL35, RPL31, RPS3, RPL37A, RPL24, RPS15A, RPL29, RPS21, RPS6, RPS19, RPS27, RPS11, RPL13A, RPS9, RPLP2, RPS13, RPL27A",0.278189384787453,0.168770306132937,FALSE
+"H1703","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38127,1.22,0.186,4518,0.567,"MAPK11, MAPK12, ATG5, DDX3Y, MAPK9, MAP3K7, TRAF3, MAPK8, CHUK, TBKBP1, AZI2, NFKB1, IKBKG, RIPK1, IFNW1, MAPK14, TRIM25, DHX58, NFKBIB, TRAF2, NFKBIA, IKBKE, SIKE1, ATG12, IRF3",0.730487055782084,0.246416941107093,FALSE
+"H1703","Input","KEGG_RNA_DEGRADATION",0.48273,1.53,0.0479,6697,0.424,"LSM1, EXOSC1, TENT4A, MTREX, HSPA9, EXOSC7, EXOSC3, DCP1B, CNOT10, LSM4, EDC4, ENO1, LSM2, EXOSC10, DCP2, EXOSC2, LSM6, EXOSC8, ZCCHC7, PAPOLB, LSM5, LSM3, PAPOLA, XRN1, SKIV2L, LSM7, EXOSC6, TTC37, EXOSC4, PARN, CNOT8, EXOSC9, CNOT9, XRN2, ENO3, CNOT1, PATL1, CNOT6",1.31966448658544,0.372634143407267,FALSE
+"H1703","Input","KEGG_RNA_POLYMERASE",0.53681,1.75,0.0124,4251,0.325,"POLR3C, POLR3G, POLR1E, POLR2J, POLR1C, POLR2E, POLR3H, POLR2H, POLR2F, POLR2B, POLR2J2, POLR3GL, POLR3A, POLR3K, POLR2A",1.90657831483776,0.488116639021126,FALSE
+"H1703","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.2498,0.806,0.735,4494,0.846,"SEPHS1, CBS, BUD23, AHCY, PAPSS2, METTL6, SCLY",0.133712660915805,0.0726296369609765,FALSE
+"H1703","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.26392,0.855,0.657,6164,0.807,"LAMC3, PIAS3, BIRC3, TRAF3, E2F2, BIRC2, CHUK, E2F3, NFKB1, LAMB2, E2F1, IKBKG, PIAS2, AKT1, XIAP, CYCS, PTEN, AKT3, TRAF1, TRAF5, RB1, LAMA5, TRAF2, NFKBIA, CCNE2, PIK3CB, CDKN1B, IKBKB, CDK2, PIAS4, PIAS1, ITGAV, ITGA3, RELA, CKS1B, TRAF4, ITGB1",0.182434630440219,0.0931264652779296,FALSE
+"H1703","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.3296,1.07,0.327,4551,0.613,"VAMP7, VAMP1, STX10, SNAP29, STX6, STX4, STX8, SNAP47, STX2, STX11, VTI1B, YKT6, GOSR2, VAMP2, STX1B, STX7",0.485452247339714,0.212539525481585,FALSE
+"H1703","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.20482,-0.768,0.789,18902,0.859,"PLPP3, SMPD1, ASAH1",0.10292299679058,0.0660068361687577,FALSE
+"H1703","Input","KEGG_SPLICEOSOME",0.58676,1.91,0.0123,4883,0.196,"MAGOHB, WBP11, SF3B4, TXNL4A, HSPA1L, PLRG1, RBM8A, PRPF8, THOC1, SNU13, RBM22, SNRPC, RBM17, SNRPD1, DHX16, HNRNPU, PRPF3, U2SURP, EFTUD2, DDX39B, ZMAT2, BUD31, SF3B5, ALYREF, PHF5A, SRSF1, HNRNPM, DDX46, PPIH, SF3A1, SNRPD3, LSM4, SRSF7, DDX42, CDC5L, SRSF3, CDC40, CCDC12, PPIL1, HSPA1A, SNRNP40, TCERG1, HNRNPA3, RBM25, LSM2, PUF60, THOC2, PRPF18, SMNDC1, LSM6, U2AF2, PRPF31, SNRPE, SRSF9, LSM5, TRA2A, NCBP1, DHX38, SART1, PRPF40A, PRPF40B, HSPA8, LSM3, U2AF1, SRSF2, HSPA1B, EIF4A3, SRSF4, AQR, SNRNP70, PRPF4, PQBP1",1.9100948885606,0.707743928643524,TRUE
+"H1703","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.33823,-1.25,0.158,11025,0.537,"UGT2B11, AMY1C, AMY1A, PGM2, GBE1, UGT2B4, UGT2B17, MGAM, UGT2A3, UGT2A1, AMY2B, UGT2B15, PYGB, UXS1, PYGM, GYS1, TREH, UGP2, GANC, ENPP3, ENPP1, AGL, UGT2B7, GCK, UGDH, HK2, PGM2L1, GAA",0.801342913045577,0.270025714300444,FALSE
+"H1703","Input","KEGG_STEROID_BIOSYNTHESIS",0.34437,1.13,0.274,1535,0.604,"SOAT1, CYP27B1, NSDHL",0.562249437179612,0.218963061378868,FALSE
+"H1703","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.31975,-1.23,0.175,15701,0.548,"CYP19A1, UGT2B7, CYP11A1, CYP3A5, AKR1C1, CYP7B1, HSD17B2, HSD11B2, HSD17B7, AKR1C2, STS, CYP1B1, HSD17B12, AKR1C3, CYP1A1, HSD17B8",0.756961951313706,0.261219441515631,FALSE
+"H1703","Input","KEGG_SULFUR_METABOLISM",-0.25162,-0.912,0.518,16233,0.701,"BPNT1, SULT1A2, SULT1A4, SULT1A1",0.285670240254767,0.154281982033341,FALSE
+"H1703","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.33097,1.06,0.345,2327,0.626,"GRIN2B, ELANE, SNRPD1, CD40, SNRPD3",0.462180904926726,0.20342566678957,FALSE
+"H1703","Input","KEGG_TASTE_TRANSDUCTION",0.49432,1.59,0.0418,1140,0.443,"TAS2R9, TAS2R7, TAS2R10, CACNA1A, TAS2R8, GNG13, TAS2R13",1.37882371822496,0.35359627377693,FALSE
+"H1703","Input","KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM",-0.45807,-1.61,0.0406,15251,0.403,"GGT6, GGT5, CDO1, GGT7",1.39147396642281,0.39469495385889,FALSE
+"H1703","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.34401,1.12,0.293,4402,0.586,"PDSS2, ACAT1, ACAT2, GGPS1, HMGCS1",0.533132379645891,0.232102383981909,FALSE
+"H1703","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28573,0.934,0.541,5434,0.744,"SMAD2, NOG, BMPR1A, PPP2CA, ROCK1, BMP6, SMURF2, TGFBR2, EP300, MAPK1, SMAD4, SMAD1, CHRD, ZFYVE16, E2F5, BMP7, RPS6KB1, RHOA, SP1, ID3, TGFB1, BMP8A, CREBBP, SMAD3, SMURF1, SMAD5, ID1, ROCK2, BMPR2, TFDP1, RBX1, E2F4",0.266802734893431,0.128427064454121,FALSE
+"H1703","Input","KEGG_THYROID_CANCER",0.2996,0.962,0.493,2591,0.724,"MAPK1, CCDC6, TPM3, KRAS, NRAS, MAP2K2",0.30715308072277,0.140261433802853,FALSE
+"H1703","Input","KEGG_TIGHT_JUNCTION",0.26716,0.847,0.671,4727,0.807,"MYH2, MAP3K20, PPP2R2C, EXOC3, MYL12B, PPP2CA, VAPA, TJAP1, YBX3, AKT1, KRAS, OCLN, CSNK2B, CTNNA1, NRAS, MYH3, JAM3, MYH9, RRAS, AFDN, MRAS, PTEN, CLDN15, YES1, RAB3B, MYL12A, RHOA, EPB41L2, PRKCA, PARD6A, AKT3, PRKCI, GNAI2, MYH1, LLGL1, MYH10, SYMPK, PRKCQ, CTNNB1, CGN",0.173277479831008,0.0931264652779296,FALSE
+"H1703","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31496,1.03,0.383,4518,0.649,"MAPK11, MAPK12, RAC1, MAPK9, MAP3K7, TRAF3, MAPK8, IFNAR2, CHUK, MAPK1, NFKB1, IKBKG, TAB1, CD40, AKT1, CCL5, RIPK1, IRAK1, MAP2K2, MAPK14, TICAM1, FOS, AKT3, MAP2K3, TAB2, MYD88, CTSK, NFKBIA, IKBKE, IRF5, IRF3",0.416801226031377,0.187755303199631,FALSE
+"H1703","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.29761,-1.13,0.233,14864,0.584,"EHHADH, AADAT, AOC1, AFMID, IDO1, DDC, IL4I1, KMO, MAOB, OGDHL, AOX1, CYP1B1, CYP1A1, MAOA, ALDH2, CAT",0.632644078973981,0.233587152887601,FALSE
+"H1703","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.36991,1.22,0.19,3347,0.567,"CACNA1A, MAPK9, SOCS3, CACNA1G, MAPK8, MTOR, MAPK1, HK3, CACNA1B, SOCS2, MAFA",0.721246399047171,0.246416941107093,FALSE
+"H1703","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.25506,-0.929,0.508,14053,0.678,"TNF, FAS, CD86, CPE, GZMB, IL1A, PTPRN2, IL1B",0.294136287716081,0.168770306132937,FALSE
+"H1703","Input","KEGG_TYROSINE_METABOLISM",0.27013,0.875,0.624,1909,0.798,"AOC2, AOC3, GOT1, BUD23, ADH5",0.204815410317576,0.0979971086492706,FALSE
+"H1703","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.37218,1.19,0.21,3697,0.558,"MALT1, MAPK11, MAPK12, NFATC1, MAP3K14, PAK2, MAPK9, NFKBIE, MAP3K7, GRB2, CBL, CHUK, MAPK1, NFKB1, IKBKG, AKT1, KRAS, PPP3R2, SOS1, RAF1, NRAS, MAP2K2, PPP3CB, MAPK14, RHOA, FOS, AKT3, NFKBIB",0.677780705266081,0.253365801062421,FALSE
+"H1703","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.39987,1.29,0.145,5645,0.598,"HERC4, UBE2G1, BTRC, NEDD4, TRIM37, PIAS3, FBXO2, SOCS3, UBE2K, NEDD4L, UBE2D2, BIRC3, SMURF2, TRIP12, UBE2A, CUL4A, CBL, FBXW11, BIRC2, CDC34, VHL, UBE2J1, PIAS2, BRCA1, XIAP, CDC20, BIRC6, UBE2R2, UBA2, CDC27, UBE2D1, COP1, UBE2Z, ANAPC1, NHLRC1, CUL4B, ANAPC7, ANAPC4, FZR1, PPIL2, CDC23, UBE2E1, UBE2E2, SIAH1, UBE2S, UBE2J2, UBE2L3, UBE2Q1, CUL7, ELOC, CUL2, UBE2B, UBE2G2, SMURF1, ERCC8, UBE2M, UBE4B, UBR5, ELOB, RBX1, PIAS4, FBXW7, UBE2D4, PIAS1, CDC16, ITCH, UBE2D3, CUL3",0.838631997765025,0.223298816011589,FALSE
+"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.45454,1.46,0.0647,4778,0.392,"PDHA1, IARS2, BCAT2, VARS2",1.1890957193313,0.406713932979543,FALSE
+"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.33547,-1.26,0.16,17618,0.548,"AOX1, ABAT, DBT, BCAT1, ALDH2, MCEE, ACADS, ALDH6A1",0.795880017344075,0.261219441515631,FALSE
+"H1703","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.1626,0.524,0.998,3616,1,"ITPR2, KCNMA1, ROCK1, ADORA2A, GNA13, PLCB3, CALML6, PLCB4, ADCY3, MAPK1, RAF1, MAP2K2, PRKACA, RHOA, PRKCA, CALM3, GNA11",0.000869458712628891,0,FALSE
+"H1703","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.27399,-0.98,0.444,17000,0.663,"RAB5B, ADCY9, CREB3L4, CREB3L1, DYNC1I1, AQP3, CREB5, ARHGDIB, CREB3L2, DCTN6",0.35261702988538,0.178486471595227,FALSE
+"H1703","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.33163,1.07,0.329,4409,0.613,"MAPK11, MAPK12, NFATC1, RAC1, HSPB1, MAPK1, AKT1, KRAS, PPP3R2, RAF1, NRAS, MAP2K2, PPP3CB, MAPK14, PRKCA, AKT3, PXN, NFAT5, PLCG2, BAD",0.482804102050026,0.212539525481585,FALSE
+"H1703","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.19574,-0.715,0.888,15082,0.902,"ATP6V0D2, CFTR, ATP6V1C2, ATP6V1G1, ATP6V1F, PDIA4, ATP6V0B, ATP6V0D1, PLCG1, ATP6V0A4, SEC61B, ADCY9, ATP6V1H, ATP6V1A, ATP6V1B2, TJP2",0.051587034221399,0.0447934624580583,FALSE
+"H1703","Input","KEGG_VIRAL_MYOCARDITIS",0.31847,1.01,0.429,2602,0.677,"MYH2, RAC1, CXADR, DAG1, CD40, CYCS, MYH3, MYH9, EIF4G1, BID",0.367542707815276,0.169411331314856,FALSE
+"H1703","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31753,1.03,0.389,3422,0.649,"APC2, CCND2, PPP2R5A, NFATC1, RAC1, SMAD2, BTRC, WNT5B, MAPK9, PPP2CA, ROCK1, NKD2, RUVBL1, MAP3K7, APC, MAPK8, FBXW11, PLCB3, EP300, PPP2R5D, PLCB4, CACYBP, CSNK1A1, PPP3R2, LRP6, CSNK2B, CTBP1, VANGL1, SMAD4, DVL1, PPP3CB, DVL2, WNT6, PRKACA, PPP2R5E, NLK, RHOA, PRKCA",0.410050398674292,0.187755303199631,FALSE
+"HCC15","Input","KEGG_ABC_TRANSPORTERS",0.44979,1.42,0.0792,2887,0.378,"ABCG2, ABCC2, ABCG1, ABCB10, ABCC1, ABCC3, ABCB6, ABCA3, ABCD1, ABCC6, ABCA7",1.10127481841051,0.422508200162775,FALSE
+"HCC15","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.28805,0.911,0.582,5403,0.925,"KIT, CHUK, PPARD, AKT1, ARAF, IKBKG, MAP2K1, MTOR, RELA, LEF1, JUP, HRAS, AKT2, NRAS, PML, SOS1, PIK3R1, SOS2, PIM1, TCF7, TCF7L2",0.235077015350112,0.0338582672609674,FALSE
+"HCC15","Input","KEGG_ADHERENS_JUNCTION",-0.23557,-0.906,0.552,18295,1,"PTPRF, CTNNB1, CSNK2A1, SNAI2, WASF3, TGFBR1, ACTN1, NECTIN3, EP300, INSR, FYN",0.258060922270801,0,FALSE
+"HCC15","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.45547,1.42,0.0835,4975,0.378,"PRKAB1, TNFRSF1B, POMC, CHUK, PRKAA2, SLC2A1, MAPK8, TRAF2, PPARA, ADIPOR1, PRKCQ, AKT1, G6PC2, IKBKG, NFKBIA, IRS1, TNFRSF1A, MTOR, RELA, CPT1A, LEPR, MAPK9, AKT2, NFKBIB, ADIPOR2, RXRA, PRKAA1, ACACB",1.0783135245164,0.422508200162775,FALSE
+"HCC15","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.21768,-0.8,0.716,17925,0.992,"IL4I1, GFPT2, ABAT, GLUL",0.145086977692144,0.00348832784582135,FALSE
+"HCC15","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.21922,0.692,0.918,1535,0.999,"PDPK1, INS, ATP1B1, SGK1, FXYD4",0.0371573187987575,0.000434511774017692,FALSE
+"HCC15","Input","KEGG_ALLOGRAFT_REJECTION",-0.21117,-0.796,0.766,4032,0.968,"FAS, CD40, IL10, GZMB, IL5, IFNG, FASLG, PRF1, CD40LG, IL2, CD28, CD80, IL4, CD86, TNF, IL12B, IL12A",0.115771230367396,0.0141246426916063,FALSE
+"HCC15","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.68384,2.17,0,1,0.115,"PLA2G1B",Inf,0.939302159646388,TRUE
+"HCC15","Input","KEGG_ALZHEIMERS_DISEASE",0.24113,0.765,0.809,4667,1,"NDUFS3, IDE, ITPR1, CASP9, CALM3, CHP1, APAF1, CALM1, CASP7, ATP5F1B, CAPN1, NDUFA9, NAE1, ATP2A2, NDUFV3, CASP8, COX5A, ITPR3, TNFRSF1A, NDUFB10, ATP5PO, NDUFA2, PPP3R1, COX7A2, NDUFB1, GAPDH, ATP5F1C, NDUFS1, PSEN2, BID, NDUFAB1, CAPN2, ATP5MC3, ATP5F1D, ADAM17, COX8A, FAS, ATF6, NCSTN, CALML6, ATP5MC2, CYC1, COX4I1, SDHD",0.0920514783877277,0,FALSE
+"HCC15","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.49543,1.57,0.0308,3522,0.321,"IARS2, EARS2, PSTK, FARSB, SEPSECS, RARS2, MTFMT, SARS2, YARS2",1.51144928349956,0.493494967595128,FALSE
+"HCC15","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.34327,1.08,0.328,5776,0.716,"GNPNAT1, UGDH, PGM3, GNPDA2, PMM2, GALK2, GPI, GFPT1, GALE, FPGT, HK3, NANS, GMDS, HK1, HEXB, PGM2, UXS1, PGM1, CMAS, HEXA",0.484126156288321,0.145086977692144,FALSE
+"HCC15","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.41376,1.29,0.144,3725,0.428,"TNFRSF1B, TOMM40, CASP9, CHP1, APAF1, SOD1, MAPK14, BCL2L1, MAP2K6, MAPK13, TNFRSF1A, MAP3K5, PPP3R1, BID",0.84163750790475,0.368556230986828,FALSE
+"HCC15","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.18466,0.588,0.974,6720,1,"NFYC, PSME2, B2M, CTSL, KLRC3, HSP90AA1, LGMN, HSP90AB1, KLRC2, PSME1, HSPA2, HSPA1A, HSPA8, PDIA3, CANX, IFI30, NFYA, HSPA5, HSPA4",0.0114410431213845,0,FALSE
+"HCC15","Input","KEGG_APOPTOSIS",0.43088,1.35,0.108,4034,0.376,"CHUK, IL3RA, CASP9, IRAK3, CHP1, APAF1, IRAK4, TRAF2, IRAK2, CASP7, ATM, AKT1, BCL2L1, CAPN1, IKBKG, NFKBIA, TNFRSF10A, MAP3K14, CASP8, CASP10, PRKACB, TNFRSF1A, RELA, PPP3R1, RIPK1, BID, CAPN2, AKT2, ENDOD1, FAS, PRKAR2A",0.96657624451305,0.424812155072339,FALSE
+"HCC15","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.53006,1.69,0.0151,1901,0.245,"PLA2G1B, LTA4H, CYP4F3, GGT5, PTGES, AKR1C3, PLA2G4A, GPX4, CBR1, GGT1",1.82102305270683,0.610833915635468,TRUE
+"HCC15","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.31591,0.994,0.44,4880,0.85,"CPS1, AZIN2, SAT1, ALDH9A1, SRM, GLUD1, GAMT, ALDH3A2, ARG2, ALDH2, GOT2, MAOA, ODC1, AGMAT, CKB, OAT, ALDH18A1, ALDH7A1, ALDH4A1",0.356547323513813,0.0705810742857073,FALSE
+"HCC15","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.22285,-0.826,0.667,15744,1,"CACNA1C, ACTN2, CACNA2D2, LAMA2, CACNA2D3, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, DMD, CACNA2D1, CTNNB1, ACTN1, ITGB8, CACNB1, CACNB3",0.175874166083451,0,FALSE
+"HCC15","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.41692,1.32,0.126,3177,0.402,"UGDH, ALDH9A1, ALDH3A2, ALDH2",0.899629454882437,0.39577394691553,FALSE
+"HCC15","Input","KEGG_ASTHMA",-0.18282,-0.671,0.924,3491,0.95,"IL13, CD40, FCER1A, IL10, IL5, IL9, MS4A2, CD40LG, IL3, FCER1G, CCL11, IL4, PRG2, RNASE3, TNF, EPX",0.0343280287798933,0.0222763947111523,FALSE
+"HCC15","Input","KEGG_AUTOIMMUNE_THYROID_DISEASE",0.25945,0.805,0.763,14161,1,"FAS, CD40, IL10, GZMB, TPO, IL5, CTLA4, IFNA4, IFNA17, IFNA6, IFNA16, FASLG, IFNA10, IFNA2, IFNA7, PRF1, IFNA14, CD40LG, IL2, CD28, TSHB, IFNA1, CD80, IFNA13, IL4, CGA, IFNA21, TG, IFNA8, IFNA5, TSHR, CD86",0.11747546204512,0,FALSE
+"HCC15","Input","KEGG_AXON_GUIDANCE",-0.33687,-1.22,0.168,15481,0.905,"EPHA7, FES, UNC5A, EPHA6, PAK3, SEMA3G, EFNA4, ROBO2, CXCL12, DPYSL5, EPHA3, EPHA4, EPHA5, DPYSL2, PAK2, EPHB2, EPHA1, SEMA6D, NTNG1, EPHB1, SRGAP1, PLXNC1, CXCR4, SEMA3D, SEMA3E, NFATC2, SEMA5A, SEMA6C, SLIT2, SEMA6A, SEMA4A, NTN1, EFNB3, PLXNB2, EFNB1, PLXNA2, UNC5B, EFNA3, PLXNB3, SEMA3A, SRGAP3, LIMK2, NFATC1, SEMA7A, L1CAM, ROBO1, FYN, ROBO3, PLXNB1, GSK3B",0.774690718274137,0.0433514207947967,FALSE
+"HCC15","Input","KEGG_BASAL_CELL_CARCINOMA",-0.18834,-0.671,0.892,15472,0.95,"WNT2B, WNT7A, PTCH2, APC2, HHIP, GLI1, DVL2, WNT10A, WNT10B, WNT5A, DVL3, FZD8, WNT7B, CTNNB1, GSK3B",0.0496351456238769,0.0222763947111523,FALSE
+"HCC15","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.46988,1.47,0.0573,2124,0.36,"TAF1L, GTF2H1, GTF2A1, TAF12, TAF9, TBPL1, GTF2H3, TBP, GTF2IRD1",1.24184537803261,0.443697499232713,FALSE
+"HCC15","Input","KEGG_BASE_EXCISION_REPAIR",0.35265,1.1,0.28,6586,0.715,"POLE2, TDG, POLE3, PARP4, POLD3, OGG1, LIG1, FEN1, POLD1, UNG, NEIL1, POLL, POLE4, LIG3, NEIL3, APEX2, NTHL1",0.552841968657781,0.145693958198919,FALSE
+"HCC15","Input","KEGG_BETA_ALANINE_METABOLISM",0.3441,1.08,0.31,4736,0.716,"HADHA, ALDH9A1, HIBCH, SRM, ALDH3A2, ALDH2, ECHS1, GAD1, ALDH7A1",0.508638306165727,0.145086977692144,FALSE
+"HCC15","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29902,0.946,0.534,4664,0.88,"HADHA, HACD1, ACOT7, ACOX1, PECR, YOD1, FADS1",0.272458742971444,0.0555173278498314,FALSE
+"HCC15","Input","KEGG_BLADDER_CANCER",-0.30586,-1.15,0.25,15843,0.84,"RAF1, MMP9, VEGFA, ERBB2, FGFR3, CDKN1A, DAPK2, MMP1, MAP2K2, VEGFB, PGF, MMP2, CDKN2A, DAPK3, DAPK1, RB1",0.602059991327962,0.0757207139381184,FALSE
+"HCC15","Input","KEGG_BUTANOATE_METABOLISM",0.35252,1.09,0.309,4736,0.72,"HADHA, ALDH9A1, ALDH3A2, ACAT1, AACS, ALDH2, ACADS, ALDH5A1, L2HGDH, ECHS1, GAD1, ACSM4, ALDH7A1",0.510041520575165,0.142667503568732,FALSE
+"HCC15","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.2376,0.743,0.844,4450,1,"NFAT5, CHUK, SYK, IFITM1, CHP1, LYN, AKT1, NFATC3, IKBKG, NFKBIA, MAP2K1, RELA, CD22, PPP3R1, HRAS, AKT2, NRAS, PTPN6, NFKBIB, SOS1",0.073657553374345,0,FALSE
+"HCC15","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.16516,0.519,0.99,3531,1,"NTSR1, ITPR1, GNAL, CALM3, VDAC2, CHP1, ADCY9, ADCY7, CALM1, GNA15, P2RX5, MYLK2, PLCD4, PHKB, ATP2A2, PHKA1, PRKACB, ITPR3, PTK2B, PPP3R1, VDAC1, ITPKA, ITPKB",0.00436480540245009,0,FALSE
+"HCC15","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.36529,-1.31,0.14,14113,1,"COX7B2, ATP1B2, MYL2, TPM4, ATP1A2, UQCR11, FXYD2, TNNC1, UQCRHL, COX8C, CACNG7, CACNA1C, TNNT2, CACNA2D2, CACNA2D3, RYR2, CACNB4, COX6B2, UQCRC1, CACNA1D, CACNG4, COX5B, UQCR10, COX6C, SLC8A1, TPM1, ATP1A3, COX7C, UQCRB, CACNA2D1, TPM2, CACNB1, CACNB3",0.853871964321762,0,FALSE
+"HCC15","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.25305,-0.942,0.485,15177,1,"VCAM1, CDH4, CLDN10, ITGA9, CDH3, CLDN16, NLGN4X, CNTNAP2, CLDN11, JAM2, NCAM2, NLGN3, CNTN1, ITGAM, NRXN2, JAM3, CD8A, CLDN22, SELL, PDCD1LG2, CADM1, NCAM1, NRXN3, NFASC, NLGN1, NECTIN1, ITGA4, NRCAM, ICOSLG, SDC2, PTPRF, NEO1, NECTIN3, ITGB8, L1CAM, SDC1",0.314258261397736,0,FALSE
+"HCC15","Input","KEGG_CELL_CYCLE",0.455,1.45,0.0643,5635,0.352,"PTTG1, CCND3, CDC25C, CDC23, ORC1, TTK, PLK1, BUB3, ANAPC4, SMAD2, BUB1, CCNB1, ORC4, ORC3, PTTG2, CCNB2, MCM6, ANAPC5, PRKDC, CHEK1, SKP1, CDC6, ATM, E2F3, ABL1, MCM3, CDC7, SMC3, YWHAQ, CDK1, BUB1B, MCM4, HDAC1, CDC45, CDC20, SMC1A, ORC2, YWHAG, E2F2, CDC25B, ANAPC7, ESPL1, ORC6, E2F4, SFN, CDC27, CCNE2, CDK2, TGFB1, CDC14A, DBF4, CDC14B, CDK6, YWHAZ, CCNH, CDKN2C, CUL1, CCNA2, ANAPC2, RBL1, MCM7, WEE2, MAD2L2, CDK7, CDKN1C, ORC5, HDAC2, STAG2, CDKN1B, WEE1, RAD21",1.19178902707578,0.453457336521869,FALSE
+"HCC15","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.20526,0.654,0.924,5017,1,"CCL5, CHUK, SHC1, ROCK2, SHC3, GNG11, GNB5, ADCY9, ADCY7, WASL, ARRB1, GSK3A, LYN, AKT1, IKBKG, NFKBIA, CCL28, MAP2K1, CDC42, CCL22, PRKACB, PTK2B, CXCL5, CCL2, RELA, HRAS, GNAI1, PXN, CXCL8, GNB1, GRK5, AKT2, GNAI3, NRAS, NFKBIB, SOS1, CCL14, PIK3R1, STAT2, GNG10, SOS2, RAP1B",0.0343280287798933,0,FALSE
+"HCC15","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.26224,0.822,0.726,5826,1,"CHUK, SHC1, SHC3, E2F3, ABL1, AKT1, ARAF, HDAC1, BCL2L1, CTBP2, IKBKG, NFKBIA, MAP2K1, CBL, E2F2, RELA, HRAS, AKT2, NRAS, TGFB1, TGFBR2, SOS1, CDK6, PIK3R1, SOS2, HDAC2, CRK, CDKN1B, MAPK3, TGFB2",0.139063379299906,0,FALSE
+"HCC15","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.33336,1.04,0.374,6488,0.783,"NPAS2, CSNK1E, ARNTL, PER2, NR1D1, PER1, CRY2",0.42712839779952,0.106238237942057,FALSE
+"HCC15","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2438,0.763,0.815,1292,1,"PC, DLAT, IDH3A",0.0888423912600234,0,FALSE
+"HCC15","Input","KEGG_COLORECTAL_CANCER",0.22631,0.714,0.877,5403,0.988,"CASP9, SMAD2, AXIN2, MAPK8, MSH2, AKT1, ARAF, APC, MAP2K1, MSH3, MSH6, APPL1, LEF1, MAPK9, AKT2, TGFB1, TGFBR2, PIK3R1, BIRC5, TCF7, TCF7L2",0.0570004066339595,0.00524305541237188,FALSE
+"HCC15","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.3153,0.992,0.455,3883,0.845,"THBD, SERPIND1, C3AR1, CFH, CD46, TFPI, PLAUR, MASP2, F13A1, C5, PLAU, SERPINC1, CD59, CFD",0.341988603342888,0.0731432910503077,FALSE
+"HCC15","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.46262,1.45,0.0708,3195,0.352,"BHMT, ADI1, MAT2A, MAT2B, TRDMT1, LDHA, SRM, AHCYL2, AHCYL1, APIP, GOT2",1.14996674231023,0.453457336521869,FALSE
+"HCC15","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.17804,0.561,0.981,672,1,"TNFSF15, TNFRSF1B, CSF2RA, CCL5, EGF, TNFSF8, KIT, FLT4, CNTF, IL3RA, IFNGR1",0.0083309926200515,0,FALSE
+"HCC15","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.34791,1.1,0.317,4369,0.715,"CCL5, CHUK, TBK1, IKBKG, POLR3K, NFKBIA, POLR3A, RELA, ZBP1, RIPK1, RIPK3, ADAR, POLR3B, POLR1C, NFKBIB, IL18",0.498940737782249,0.145693958198919,FALSE
+"HCC15","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.22816,-0.869,0.601,14773,1,"SGCD, TNF, TNNC1, DES, CACNG7, ITGA9, ADCY1, CACNA1C, TNNT2, CACNA2D2, LAMA2, CACNA2D3, ADCY5, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, TPM1, DMD, CACNA2D1, ITGB8, GNAS, TPM2, CACNB1, CACNB3",0.22112552799726,0,FALSE
+"HCC15","Input","KEGG_DNA_REPLICATION",0.60201,1.9,0.00238,4243,0.207,"DNA2, MCM6, POLE2, RFC5, POLE3, MCM3, MCM4, POLA1, RFC2, PRIM1, POLA2, PRIM2, POLD3, RFC1, RPA2, RNASEH1, RPA1, LIG1, FEN1, POLD1",2.62342304294349,0.684029654543082,TRUE
+"HCC15","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.15222,-0.578,0.971,16707,0.985,"ETV7, FMN2, NOTCH4, CPEB1",0.0127807700919951,0.00656376950238827,FALSE
+"HCC15","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.15554,0.49,0.996,3621,0.997,"ALDH3A1, ALDH3B1, GSTM2, GSTM4, GSTM3, CYP3A5, MAOA, MGST1",0.00174066157630127,0.00130484168834428,FALSE
+"HCC15","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.30544,-1.2,0.191,17562,0.865,"ITPA, XDH, UMPS, GMPS, NAT1, IMPDH2, UCKL1",0.718966632752272,0.0629838925351858,FALSE
+"HCC15","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.2005,-0.752,0.839,15298,0.966,"COL11A1, LAMC1, ITGA9, RELN, COL5A3, COL6A1, LAMA2, COL6A3, THBS2, ITGA7, CHAD, COL1A2, COL4A2, FN1, THBS4, ITGA4, LAMA4, ITGB3, COL6A2, SV2A, SDC2, THBS3, LAMB1, ITGB8, SDC1, CD47",0.0762380391712997,0.0150228735845067,FALSE
+"HCC15","Input","KEGG_ENDOCYTOSIS",0.27333,0.866,0.683,4500,0.971,"DNM3, EGF, STAM, AP2S1, KIT, IQSEC2, RAB11FIP2, RAB11A, USP8, ARRB1, STAM2, SH3KBP1, SMAP1, AP2A2, VTA1, SMURF2, SMAP2, NEDD4, TSG101, GIT2, ASAP1, CBL, PIKFYVE, EEA1, CDC42, STAMBP, RUFY1, ACAP3, CHMP4C, VPS4A, ARAP2, ASAP2, CHMP4A, SH3GLB2, LDLRAP1, VPS37A, WWP1, DNAJC6, SH3GLB1, HRAS, CLTCL1, GRK5, CHMP1B, DNM1L, AP2B1, DNM1, ARFGAP2, RAB31, IGF1R, CLTB, RAB11FIP3",0.165579296318467,0.0127807700919951,FALSE
+"HCC15","Input","KEGG_ENDOMETRIAL_CANCER",0.29474,0.946,0.515,5551,0.88,"EGF, PDPK1, CASP9, AXIN2, AKT1, CTNNA1, ARAF, APC, MAP2K1, LEF1, HRAS, AKT2, ILK, NRAS, SOS1, PIK3R1, ELK1, SOS2, TCF7, PTEN, TCF7L2, CDH1",0.288192770958809,0.0555173278498314,FALSE
+"HCC15","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.44259,1.39,0.0896,4447,0.396,"CCL5, ATP6V0A4, CHUK, MAPK8, TJP1, LYN, MAPK14, ATP6V0E1, ATP6V1E1, ATP6V1C1, ATP6V0A1, ATP6V1H, IKBKG, ATP6V0B, NFKBIA, TCIRG1, ATP6V0D1, CDC42, MAP3K14, ATP6V0C, MAPK13, MAP2K4, RELA, ATP6V1A, ATP6V0E2, CXCL8, MAPK9, ADAM17, HBEGF, ATP6V1G1, ATP6V0A2",1.04769199033787,0.402304814074488,FALSE
+"HCC15","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.19345,-0.747,0.784,17973,0.946,"SHC2, MAPK10, EIF4EBP1, PIK3CD, MAP2K7, AKT3, PLCG1, PIK3R2, JUN, GSK3B, GAB1",0.105683937315562,0.0241088635982073,FALSE
+"HCC15","Input","KEGG_ETHER_LIPID_METABOLISM",0.60914,1.93,0.00354,2363,0.227,"PLA2G1B, PAFAH2, PAFAH1B2, PAFAH1B3, PLA2G4A, PLPP3, CHPT1",2.45099673797421,0.643974142806877,TRUE
+"HCC15","Input","KEGG_FATTY_ACID_METABOLISM",0.35784,1.12,0.294,3417,0.695,"HADHA, ECI1, HADHB, ACADSB, ALDH9A1, ALDH3A2, ACOX1, ACAT1, ALDH2, CPT1A, ACADS",0.531652669587843,0.158015195409886,FALSE
+"HCC15","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.34356,1.07,0.334,3845,0.722,"PLA2G1B, SYK, PDPK1, MAPK8, LYN, MAPK14, AKT1, PLA2G4A, PRKCE, MAP2K1, MAP2K6, MAPK13, MAP2K4, IL13, HRAS, MAPK9, AKT2",0.476253533188435,0.141462802430361,FALSE
+"HCC15","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.26261,0.832,0.72,4238,1,"DNM3, SYK, CFL2, ARPC2, WASL, ARPC5L, LYN, AKT1, PLA2G4A, WASF2, PLPP3, PRKCE, ARPC3, ASAP1, MAP2K1, PIKFYVE, CDC42, ASAP2, CFL1, MYO10, DNM1L, AKT2, LIMK1, DNM1, ARPC4",0.142667503568732,0,FALSE
+"HCC15","Input","KEGG_FOCAL_ADHESION",0.18106,0.574,0.988,5638,1,"COL4A6, ITGA10, EGF, CCND3, FLT4, PDPK1, FLNB, SHC1, ROCK2, ITGA1, SHC3, COL3A1, MAPK8, DIAPH1, COL5A2, MYLK2, AKT1, ITGB5, MAP2K1, PARVA, CDC42, ARHGAP35, ITGB7, PPP1CC, COL4A4, ITGB4, ACTN4, ITGA2, HRAS, ARHGAP5, LAMB3, PXN, CAPN2, MAPK9, AKT2, ILK, PPP1CA, IGF1R, PPP1CB, SOS1, XIAP, ITGA6, ITGB1, PIK3R1, ELK1, SOS2, RAP1B, PTEN, BIRC2, LAMA1, RAPGEF1, PAK1, PRKCA, ITGA11, CRK, VCL, BIRC3, LAMB2, BCAR1",0.00524305541237188,0,FALSE
+"HCC15","Input","KEGG_FOLATE_BIOSYNTHESIS",0.49637,1.54,0.0457,4914,0.336,"PTS, SPR, DHFR, GCH1, GGH, FPGS",1.34008379993015,0.473660722610156,FALSE
+"HCC15","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.27561,0.879,0.642,6028,0.968,"PFKP, PMM2, MTMR2, ALDOA, FPGT, SORD, HK3, GMDS, HK1, KHK, MTMR7, MTMR6, PHPT1",0.192464971931147,0.0141246426916063,FALSE
+"HCC15","Input","KEGG_GALACTOSE_METABOLISM",0.35175,1.11,0.296,3599,0.711,"GLA, PFKP, B4GALT1, G6PC2, GALK2, GALE, HK3",0.528708288941061,0.148130399270234,FALSE
+"HCC15","Input","KEGG_GAP_JUNCTION",0.23255,0.729,0.843,5227,1,"TUBAL3, EGF, ITPR1, ADCY9, ADCY7, MAP3K2, TJP1, CDK1, LPAR1, MAP2K1, PRKACB, ITPR3, TUBB3, HRAS, GNAI1, GNAI3, NRAS, SOS1, TUBB2A, SOS2, TUBA1C, TUBB, TUBA4A, TUBA1B",0.0741724253752577,0,FALSE
+"HCC15","Input","KEGG_GLIOMA",0.23961,0.755,0.823,4999,1,"EGF, SHC1, SHC3, CALM3, CALM1, E2F3, AKT1, ARAF, TGFA, MAP2K1, E2F2, MTOR, HRAS, AKT2, NRAS, IGF1R, SOS1, CALML6, CDK6, PIK3R1, CALM2, SOS2",0.0846001647877302,0,FALSE
+"HCC15","Input","KEGG_GLUTATHIONE_METABOLISM",0.5227,1.68,0.0151,4965,0.22,"GCLC, PGD, GSR, GCLM, G6PD, GGT5, RRM1, TXNDC12, GPX4, SRM, GGT1, GSTM2, GSTM4, GSS, GSTM3, RRM2, ODC1, GPX7, MGST1, GPX3, MGST2, GSTO1, GSTK1, RRM2B",1.82102305270683,0.657577319177794,TRUE
+"HCC15","Input","KEGG_GLYCEROLIPID_METABOLISM",0.35194,1.09,0.312,3355,0.72,"GLA, AGPAT3, DGKG, AKR1A1, ALDH9A1, PLPP3, GPAT3, ALDH3A2, DGKD, MBOAT1, ALDH2, TKFC",0.505845405981557,0.142667503568732,FALSE
+"HCC15","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.43918,1.37,0.0898,2870,0.36,"PLA2G1B, AGPAT3, PTDSS2, DGKG, PTDSS1, GPD2, LYPLA2, MBOAT7, PLA2G4A, ETNK1, PLPP3, GPAT3, LYPLA1, CHPT1, DGKD, GNPAT, MBOAT1",1.0467236633327,0.443697499232713,FALSE
+"HCC15","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.25618,0.812,0.734,3612,1,"BHMT, DMGDH, GAMT, SHMT1, MAOA, DLD",0.134303940083929,0,FALSE
+"HCC15","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.39976,1.26,0.175,4179,0.468,"ALDH3A1, ENO3, ENO1, PFKP, DLAT, AKR1A1, ALDH3B1, ALDH9A1, G6PC2, LDHA, ALDH3A2, GPI, PGAM1, GALM, PKM, ALDOA, ALDH2, GAPDH, HK3, DLD, ACSS2, LDHAL6B",0.756961951313706,0.329754146925876,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.29443,0.919,0.559,4809,0.924,"CHST15, CSGALNACT1, B3GAT3, DSE, CSGALNACT2, B3GAT2, CHST7",0.252588192113577,0.0343280287798933,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.27858,-1.03,0.359,15306,0.932,"HS3ST5, NDST3, B3GAT1, HS3ST3B1, B4GALT7, HS3ST1, HS3ST3A1, NDST1, XYLT1, HS6ST2, XYLT2, EXT1",0.444905551421681,0.0305840876460186,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.45621,-1.74,0.0288,17191,1,"B3GNT7, CHST2, FUT8, ST3GAL1, B3GNT2, B4GALT4, B4GALT2",1.54060751224077,0,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.44304,1.4,0.0805,6089,0.391,"HYAL1, GUSB, GALNS, GNS, ARSB, HGSNAT, NAGLU, HEXB, SGSH, HEXA, HYAL3",1.09420411963213,0.407823242604133,FALSE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.27762,-1.06,0.333,14743,0.907,"GLB1, B3GALT4, ST6GALNAC6, ST8SIA1, ST6GALNAC5, ST3GAL1, SLC33A1",0.47755576649368,0.0423927129399047,FALSE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3276,1.02,0.426,71,0.818,"GLA",0.370590400897281,0.087246696328677,FALSE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.32609,-1.24,0.152,16056,0.956,"B3GALT1, ABO, B3GALT5, FUT3, ST8SIA1, B3GNT2, ST3GAL6, B4GALT4, B4GALT2",0.818156412055227,0.0195421077238999,FALSE
+"HCC15","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.3429,1.08,0.327,2640,0.716,"PIGN, PIGB, DPM2, PGAP1, PIGP, PIGU",0.485452247339714,0.145086977692144,FALSE
+"HCC15","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.27868,0.873,0.66,2851,0.963,"PGP, CS",0.180456064458131,0.0163737128754655,FALSE
+"HCC15","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.33809,1.07,0.323,3080,0.722,"PLA2G1B, ITPR1, CALM3, ADCY9, ADCY7, CALM1, MAPK8, MAP3K2, MAPK14, PLA2G4A, MAP2K1, CDC42, MAP2K6, PRKACB, MAPK13, ITPR3, PTK2B, MAP2K4",0.490797477668897,0.141462802430361,FALSE
+"HCC15","Input","KEGG_GRAFT_VERSUS_HOST_DISEASE",-0.23138,-0.866,0.65,9778,1,"IFNG, FASLG, PRF1, KIR2DL1, KIR3DL2, IL2, KLRD1, CD28, KIR3DL1, KIR2DL3, CD80, KLRC1, CD86, IL6, TNF, IL1B",0.187086643357144,0,FALSE
+"HCC15","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.19735,0.616,0.956,2636,1,"BTRC, CSNK1E, BMP4, CSNK1G1, GLI2, CSNK1G2, WNT3, PRKACB",0.0195421077238999,0,FALSE
+"HCC15","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.2343,0.736,0.846,675,1,"CD14, CSF2RA, KIT, IL3RA, ITGA1",0.0726296369609765,0,FALSE
+"HCC15","Input","KEGG_HISTIDINE_METABOLISM",0.4684,1.46,0.0617,5111,0.361,"AMDHD1, ALDH3A1, TRMT11, ALDH3B1, ALDH9A1, HAL, ALDH3A2, METTL2B, ALDH2, MAOA, BUD23, ALDH7A1, HDC, LCMT2, LCMT1",1.20971483596676,0.442492798094342,FALSE
+"HCC15","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.43939,1.37,0.0995,5951,0.36,"XRCC3, RAD51, BLM, MRE11, RAD54B, POLD3, RPA2, MUS81, RAD54L, RPA1, NBN, XRCC2, POLD1, RAD50, RAD51D, RPA3, RPA4, TOP3A, EME1, RAD52",1.00217691925427,0.443697499232713,FALSE
+"HCC15","Input","KEGG_HUNTINGTONS_DISEASE",0.26277,0.824,0.711,4667,1,"NDUFS3, RCOR1, AP2S1, POLR2J2, ITPR1, BDNF, CASP9, VDAC2, APAF1, SOD1, TGM2, ATP5F1B, AP2A2, POLR2E, TBPL1, HDAC1, DCTN4, TBP, SP1, NDUFA9, POLR2D, POLR2A, NDUFV3, CASP8, POLR2C, CREB3L2, COX5A, NDUFB10, ATP5PO, POLR2L, NDUFA2, VDAC1, COX7A2, NDUFB1, ATP5F1C, CLTCL1, NDUFS1, NDUFAB1, POLR2G, ATP5MC3, DNAH1, TFAM, ATP5F1D, COX8A, SIN3A, AP2B1, CLTB, ATP5MC2, CYC1, COX4I1, SDHD",0.148130399270234,0,FALSE
+"HCC15","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.21991,-0.841,0.669,14165,1,"MYL2, SGCG, TPM4, PRKAG1, IGF1, IL6, SGCD, TNF, TNNC1, DES, CACNG7, PRKAG2, ITGA9, CACNA1C, ACE, TNNT2, CACNA2D2, LAMA2, CACNA2D3, ITGA7, RYR2, CACNB4, CACNA1D, CACNG4, ITGA4, SLC8A1, ITGB3, TPM1, DMD, CACNA2D1, ITGB8, TPM2, CACNB1, CACNB3",0.174573882232177,0,FALSE
+"HCC15","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.23102,-0.863,0.62,17903,0.986,"PIP5K1C, PIK3C3, PLCE1, PIK3CD, ALDH6A1, INPP5J, PLCG1, PLCB1, INPP4B",0.207608310501746,0.0061230850587888,FALSE
+"HCC15","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.2936,0.913,0.572,4999,0.93,"PRKAB1, PDE3A, PPP1R3C, PRKAA2, PDPK1, MKNK2, SHC1, INS, SHC3, CALM3, CALM1, MAPK8, MKNK1, AKT1, ARAF, G6PC2, PHKB, MAP2K1, CBL, PHKA1, PRKACB, PPP1CC, IRS1, MTOR, SORBS1, ACACA, HRAS, HK3, MAPK9, AKT2, PRKAR2A, SOCS4, PPP1CA, NRAS, PPP1CB, SOS1, PHKG2, CALML6, HK1, TSC1, PIK3R1, PRKAA1, CALM2, ELK1, ACACB, SOS2",0.242603971206976,0.0315170514460649,FALSE
+"HCC15","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.19757,-0.725,0.89,17241,0.956,"CXCR4, ITGA4, CCR10, ICOSLG, IL15",0.0506099933550872,0.0195421077238999,FALSE
+"HCC15","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.17092,0.532,0.998,5338,1,"CSF2RA, CCND3, STAM, CNTF, IL3RA, IFNGR1, STAM2, AKT1, SPRED2, BCL2L1, SPRED1, IL10RB, CBL, IL22RA1, SPRY4, PIAS1, IFNLR1, LEPR, IL13, AKT2, SOCS4, PTPN6, IL13RA1, IFNAR1, SPRY1, SOS1, PIK3R1, STAT2, OSMR, SOS2, PIM1, MPL, IFNAR2, IL4R, IL20RA",0.000869458712628891,0,FALSE
+"HCC15","Input","KEGG_LEISHMANIA_INFECTION",0.18164,0.573,0.986,6037,1,"IFNGR1, IRAK4, MAPK14, NFKBIA, MAPK13, PTGS2, RELA, MAP3K7, TGFB1, PTPN6, NFKBIB, ITGB2, ITGB1, ELK1, TAB2, TRAF6, CYBA, MAPK3, TGFB2, IL10",0.0061230850587888,0,FALSE
+"HCC15","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.20078,0.634,0.954,5638,1,"CLDN2, TXK, ROCK2, RASSF5, MAPK14, CTNNA1, SIPA1, CD99, CDC42, ARHGAP35, MAPK13, PTK2B, CLDN4, ACTN4, ARHGAP5, CTNND1, GNAI1, PXN, CLDN23, MSN, GNAI3, NOX1, ITGB2, ITGB1, PIK3R1, CLDN3, ESAM, CLDN20, RAP1B, EZR, PRKCA, ICAM1, CYBA, VCL, BCAR1",0.0204516252959049,0,FALSE
+"HCC15","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.57214,1.81,0.00941,4736,0.243,"HADHA, ALDH9A1, ALDH3A2, ALDH2, ECHS1, YOD1, ALDH7A1",2.02641037657274,0.614393726401688,TRUE
+"HCC15","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.59268,1.87,0.00595,1,0.2,"PLA2G1B",2.22548303427145,0.698970004336019,TRUE
+"HCC15","Input","KEGG_LONG_TERM_DEPRESSION",0.41246,1.3,0.139,1786,0.419,"PLA2G1B, PPP2R1B, ITPR1, GNA13, PPP2R1A, LYN, ARAF, PLA2G4A",0.856985199745905,0.377785977033705,FALSE
+"HCC15","Input","KEGG_LONG_TERM_POTENTIATION",0.22951,0.721,0.856,6597,1,"ITPR1, CALM3, CHP1, CALM1, ARAF, MAP2K1, PRKACB, PPP1CC, ITPR3, PPP3R1, HRAS, RPS6KA1, PPP1CA, NRAS, PPP1CB, CALML6, CALM2, RAP1B, PPP3CB, PRKCA, MAPK3, RAP1A, PPP1R12A, RPS6KA3, PLCB3, PPP3CC, GRIN1",0.0675262353228468,0,FALSE
+"HCC15","Input","KEGG_LYSINE_DEGRADATION",0.43876,1.38,0.104,4736,0.382,"HADHA, KMT5A, SUV39H1, AASDHPPT, ALDH9A1, EHMT1, ALDH3A2, SETD1B, ACAT1, ALDH2, SETD1A, TMLHE, PLOD1, ECHS1, SUV39H2, SETD7, EHMT2, ASH1L, NSD1, ALDH7A1",0.98296666070122,0.417936637088291,FALSE
+"HCC15","Input","KEGG_LYSOSOME",0.40725,1.26,0.163,5776,0.468,"GLA, HYAL1, ATP6V0A4, AP1S3, AP4E1, AP3M1, AP3B1, AP4B1, FUCA1, ARSG, SLC11A2, CLN3, ACP2, CD164, SLC17A5, GUSB, ATP6V0A1, SORT1, SLC11A1, ATP6V1H, ATP6V0B, GALNS, TCIRG1, ATP6V0D1, AP1G1, ATP6V0C, MFSD8, GNS, NAGPA, ARSB, CTSL, CTSF, CLTCL1, HGSNAT, AP3S1, GM2A, GNPTAB, LGMN, GNPTG, ATP6V0A2, CLTB, PPT1, NAGLU, PPT2, SMPD1, HEXB, ABCA2, PLA2G15, IGF2R, CTSV, TPP1, SGSH, GBA, M6PR, HEXA",0.787812395596042,0.329754146925876,FALSE
+"HCC15","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.23077,0.716,0.848,3405,1,"PLA2G1B, FGF9, FGF19, CD14, EGF, PPP5C, CHUK, FLNB, BDNF, RPS6KA5, MKNK2, CHP1, MEF2C, MAPK8, MAP3K2, MKNK1, TRAF2, ARRB1, DUSP4, MAPK14, AKT1, PLA2G4A, MAP4K3, MAP3K8, IKBKG, NR4A1, MAP2K1, CDC42, MAP3K14, MAP2K6, PRKACB, MAPK13, ATF2, TAOK2, MAPKAPK5, TNFRSF1A, MAP2K4, STK3, CDC25B, RELA, MAP3K5, PPP3R1",0.0716041477432862,0,FALSE
+"HCC15","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.24869,-0.882,0.537,13942,1,"ONECUT1, HNF4A, HNF1A, BHLHA15, FOXA2, PDX1, GCK, HNF1B, NR5A2, HNF4G",0.270025714300444,0,FALSE
+"HCC15","Input","KEGG_MELANOGENESIS",0.16347,0.522,0.995,5572,1,"POMC, KIT, CALM3, ADCY9, ADCY7, CALM1, FZD3, MAP2K1, WNT3, PRKACB, CREB3L2, LEF1, HRAS, DVL1, GNAI1, GNAI3, MC1R, NRAS, CALML6, FZD9, FZD6, EDN1, CALM2, TCF7, TCF7L2, PRKCA, FZD1",0.00217691925427455,0,FALSE
+"HCC15","Input","KEGG_MELANOMA",-0.24001,-0.892,0.576,16661,1,"FGF11, PIK3CA, CDKN1A, FGF2, FGF22, FGF1, PDGFRB, MAP2K2, PDGFD, FGF13, FGF12, MITF, PIK3CD, CDKN2A, AKT3, PDGFC, PIK3R2, RB1",0.239577516576788,0,FALSE
+"HCC15","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.36037,1.13,0.282,3651,0.702,"ALDH3A1, CYP2S1, EPHX1, AKR1C2, AKR1C1, AKR1C3, ALDH3B1, GSTM2, GSTM4, GSTM3, CYP3A5, MGST1, CYP1B1",0.549750891680639,0.153662887870195,FALSE
+"HCC15","Input","KEGG_MISMATCH_REPAIR",0.55307,1.75,0.0151,5582,0.303,"MSH2, RFC5, RFC2, MSH3, POLD3, RFC1, MSH6, RPA2, RPA1, LIG1, POLD1, EXO1, RPA3, RPA4",1.82102305270683,0.518557371497695,FALSE
+"HCC15","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.29786,0.93,0.553,1866,0.915,"MLST8, PRKAA2, PDPK1, CAB39, INS, AKT1, EIF4B, ULK3, RICTOR",0.257274868695302,0.0385789059335517,FALSE
+"HCC15","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.32687,1.02,0.425,4493,0.818,"RAET1G, RAET1E, SH2D1B, NFAT5, ULBP3, SYK, SHC1, IFNGR1, SHC3, CHP1, ARAF, ICAM2, NFATC3, MAP2K1, TNFRSF10A, MICB, PTK2B, MICA, KLRC3, PPP3R1, HRAS, BID, FAS, KLRC2, NRAS, PTPN6, IFNAR1, SOS1, ITGB2",0.371611069949688,0.087246696328677,FALSE
+"HCC15","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.2196,-0.81,0.667,11147,1,"OPRK1, GRIN2A, HTR2B, NPY2R, GABRG1, TAAR1, GRM6, MC2R, FSHR, CYSLTR2, HTR1E, CHRND, GABRA1, PRL, P2RY10, HTR4, GH1, GRM1, P2RX3, HTR1F, TSHB, ADRA1A, HCRTR2, GABRA4, NMUR1, GPR50, F2, CHRNG, RXFP1, MC5R, DRD5, MCHR1, GCGR, CHRM1, MC3R, HTR6, AVPR1A, CYSLTR1, GABRB2, GRIN3A, CALCR, GRM7, P2RX4, AVPR1B, TACR3, HRH3, ADCYAP1R1, HTR2A, GABRR2, GRIA1, CGA, NPY5R, GRM5, NMUR2, THRB, P2RY8, UTS2R, LHB, NPFFR1, CHRNB1, GRM3, NPY4R, HTR1B, GHSR, CHRNA4, PRSS2, P2RY13, GHRHR, GABRR1, GRIK3, CHRM2, F2RL3, GRIA4, CHRNA1, P2RX2, P2RX1, GABRD, PTGER3, GABRA5, PRSS1, MC4R, MCHR2, GRIA2, TACR2, CHRNA3, ADRA2C, GABRB1, P2RX6, GABRG3, TRHR, SCTR, CRHR1, CHRNB2, TSHR, PLG, GRID2, OPRD1, GRIA3, DRD1, CTSG, GRM2, GRM4, LPAR4, GRIN2C, TBXA2R, GABRA2, GABRG2, ADRA2A, GABRP, PTGIR, PTGER4, ADRA1D, NPBWR1, GRIN2B, CHRNA9, AGTR1, SSTR2, GRIN2D, CHRNB4, GRIK5, P2RY14, MLNR, MTNR1A, PTH2R, ADRA2B, GRM8, EDNRB, SSTR1, NPFFR2, NPY1R, CNR1, DRD2, PTAFR, DRD4, CHRNE, PTGER1, S1PR3, HTR2C, GALR3, GRID1, PRLR, NMBR, GABBR2, GRIK4, GPR83, GRPR, AVPR2, S1PR5, GPR35, GABRQ, PTGFR, PTGER2, PTH1R, OXTR, VIPR1, GHR, LPAR2, P2RX7, CHRM4, PRSS3, P2RY1, LPAR3, HRH4, GRIK2, BDKRB1, ADORA1, ADRA1B, BDKRB2, GABRA3, OPRL1, ADORA2A, ADORA2B, GLRB, S1PR2, GABBR1",0.175874166083451,0,FALSE
+"HCC15","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.23263,0.737,0.86,5017,1,"PDPK1, BDNF, RPS6KA5, SHC1, SHC3, CALM3, IRAK3, IRAK4, CALM1, MAPK8, IRAK2, ABL1, MAPK14, PRDM4, AKT1, YWHAQ, SORT1, NFKBIA, KIDINS220, MAP2K1, CDC42, YWHAG, MAPK13, IRS1, RELA, MAP3K5, HRAS, MAPK9, AKT2, RPS6KA1, NRAS, NFKBIB, SOS1, CALML6, YWHAZ, ZNF274, PIK3R1, CALM2, SOS2, RAP1B",0.0655015487564323,0,FALSE
+"HCC15","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.46767,1.48,0.0657,3025,0.358,"NMNAT1, NAMPT, NNMT, NADK, NT5C2, NT5M, NT5E, NMRK1, NNT",1.18243463044022,0.446116973356126,FALSE
+"HCC15","Input","KEGG_NITROGEN_METABOLISM",0.28502,0.907,0.584,1956,0.926,"CA12, CPS1, HAL, GLUD1",0.233587152887601,0.0333890133180656,FALSE
+"HCC15","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31908,1,0.457,5819,0.854,"CCL5, CHUK, MAPK8, MAPK14, IKBKG, NFKBIA, CASP8, MAPK13, CCL2, RELA, MAP3K7, CXCL8, HSP90AA1, MAPK9, HSP90AB1, NFKBIB, IL18, XIAP, PYCARD, NOD1, ERBIN, TAB2, TAB3, BIRC2, CARD6, TRAF6, BIRC3, SUGT1, MAPK3",0.34008379993015,0.068542129310995,FALSE
+"HCC15","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.53642,1.68,0.0211,4654,0.22,"XRCC5, NHEJ1, PRKDC, XRCC4, MRE11, DCLRE1C, FEN1, RAD50",1.67571754470231,0.657577319177794,TRUE
+"HCC15","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.22852,0.717,0.875,4999,1,"EGF, PDPK1, CASP9, RASSF5, E2F3, AKT1, ARAF, TGFA, MAP2K1, E2F2, HRAS, AKT2, NRAS, SOS1, CDK6, PIK3R1, RXRA, SOS2",0.0579919469776868,0,FALSE
+"HCC15","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.20514,-0.763,0.76,16674,0.974,"DTX1, DLL1, DVL2, SNW1, CTBP1, DVL3, APH1A, MFNG, NOTCH4, DTX4, EP300",0.119186407719209,0.0114410431213845,FALSE
+"HCC15","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.54037,1.7,0.021,5582,0.28,"XPA, GTF2H1, ERCC3, POLE2, RFC5, POLE3, GTF2H3, RFC2, DDB2, DDB1, CUL4B, ERCC8, POLD3, RFC1, ERCC4, RPA2, RPA1, ERCC6, LIG1, POLD1, CCNH, GTF2H5, CDK7, RPA3, RPA4",1.67778070526608,0.552841968657781,FALSE
+"HCC15","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.38251,1.2,0.196,5764,0.547,"ALG9, MGAT5, MGAT5B, DPAGT1, GANAB, ALG1, B4GALT1, DPM2, STT3A, ALG6, ALG13, MAN2A2, ALG8, DPM3, DOLPP1, ALG2, ALG10, TUSC3, MAN1A1, RFT1, MGAT4B, STT3B, DDOST, MGAT2",0.707743928643524,0.262012673666569,FALSE
+"HCC15","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.28237,-1.09,0.329,8964,0.949,"OR4C16, OR5D13, OR2Z1, OR5AR1, OR2AT4, OR10G8, OR5F1, OR4A5, OR1D4, OR8K5, OR5AP2, OR51S1, OR4D9, OR8I2, OR8H1, OR4D6, OR8H3, OR4C46, OR2T27, OR10H4, OR4A15, OR4K5, OR5D16, OR4C13, OR2A42, OR51A2, OR4K13, OR5T3, OR5I1, OR5D14, OR4K15, OR51G2, OR5AS1, OR4C15, OR4X1, OR6C3, OR51L1, OR52I1, OR10G7, OR4C12, OR5T1, OR4C11, OR5M9, OR6Y1, OR10A7, OR7G3, OR7C2, OR10G9, OR4K2, OR2M7, OR8J1, OR4M1, OR4K17, OR4P4, OR1A2, OR7A10, OR13C5, OR1S2, OR51F2, OR4N5, OR51V1, OR4C45, OR6N2, OR7G2, OR2G2, OR5M3, OR8H2, OR5L1, OR2G3, OR2T34, OR8J3, OR5M10, OR5AC2, OR2Y1, ARRB2, OR7G1, OR4Q3, OR5A1, OR4S2, OR1A1, OR6Q1, OR8K1, OR52K2, OR6C4, OR8U1, OR13C8, OR8K3, OR51T1, OR10X1, OR9K2, OR51A4, OR1S1, OR51D1, OR5D18, OR2T3, OR4L1, OR10H3, OR4D11, OR4D10, OR2T1, OR51A7, OR5J2, OR9G4, OR6C65, OR5L2, OR5B3, OR10G3, OR1D2, OR52M1, OR5AN1, OR5B17, OR52R1, OR9Q1, OR6K2, OR4B1, OR5A2, OR10P1, OR10R2, OR11A1, OR5H6, OR4C3, OR10J1, OR10K2, OR51E2, OR9Q2, OR6C68, OR6C74, OR10C1, CLCA1, OR5M1, OR11G2, OR6C75, OR6C76, OR10Q1, OR1D5, OR4K14, OR6K6, OR12D3, OR14J1, OR5M8, OR13C9, OR51F1, OR6N1, OR2F2, OR5H2, OR1I1, OR7A17, OR7D4, OR8D4, OR2T5, OR10T2, OR5B12, OR4E2, OR10J5, CNGA3, OR10K1, OR2M5, OR6K3, OR11L1, OR52K1, OR4S1, OR1L1, OR1E2, OR4F6, OR4K1, OR51G1, OR2G6, OR10Z1, OR2T10, OR12D2, OR4D2, OR4N4, OR1N1, OR10G4, OR14C36, OR2T2, OR14A16, OR6S1, OR1N2, OR5AK2, OR2T29, OR2T11, OR10G2, OR52E8, OR52E2, OR52A5, OR51E1, OR4D5, OR5AU1, OR13F1, OR1E1, OR10AG1, OR6X1, OR2L8, OR4F4, OR5V1, OR6C1, OR10H5, OR2M2, OR1L3, OR2W1, OR56A1, OR4A16, OR2H1, OR56A5, OR56A4, OR2T4, OR2T6, GUCA1A, OR1L6, OR13C4, OR2T12, OR6V1, OR2B3, OR4A47, OR52B4, OR2M3, OR11H1, OR13C3, OR6M1, OR6B1, OR6C2, OR52N5, OR5T2, OR52N1, OR8B4, OR52L1, OR2C3, OR1G1, OR4X2, OR10J3, OR2F1, OR6F1, OR4N2, OR52E6, OR7E24, OR3A3, OR52E4, OR9I1, OR4M2, OR1L4, GUCA1C, OR2T33, OR2M4, OR7A5, OR8B8, OR9G1, OR52I2, OR8B12, OR9A4, OR51I2, OR6B3, OR2A4, OR13C2, OR2J2, OR3A1, OR6C70, OR10A5, OR56A3, OR10H2, OR10AD1, OR52B2, OR51M1, OR1B1, OR2L3, OR52N4, OR10V1, CLCA4, PRKACG, OR6T1, OR10S1, OR51B6, OR2AK2, OR56B1, OR4F5, OR3A2, OR5P2, OR5B21, OR5M11, OR8G5, OR13G1, GUCA1B, OR2L13, OR5K1, OR4C6, OR1M1, OR51B2, OR52D1, OR51I1, OR5P3, OR52N2, OR8S1, OR9A2, OR51Q1, CALML3, OR13D1, OR8D2, OR1J2, OR2S2, OR2A5, OR52H1, OR52A1, OR1C1, OR14I1, OR5C1, OR1J4, OR2B11, ADCY3, OR2T8, OR2C1, OR8G1, OR4F15, OR52B6, OR2A25, OR2D3, OR1Q1, OR10H1, PRKACA, OR8A1, CALML5, OR2B2, OR1K1, OR2J3, OR10A6, OR2A2, OR4F3, OR10A4, GUCY2D, OR51B4, CAMK2A, OR13A1, OR6B2, OR2A12, OR2D2, OR2AG1, OR10A3, OR2K2, OR7C1, OR13H1, OR10A2, OR2A14, OR13J1, OR4F16, CLCA2, OR2H2, OR4F17, CNGB1, OR2W3, OR6A2, OR56B4, OR5K2, OR1L8, OR2AE1, OR1J1, OR2L2, CNGA4, CAMK2B, PDE1C, PRKG1, OR2AG2, PRKG2, GRK3",0.482804102050026,0.0227337875727074,FALSE
+"HCC15","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.47145,1.49,0.0557,3375,0.356,"ATIC, MTHFS, MTFMT, SHMT1, GART, DHFR",1.25414480482627,0.448550002027125,FALSE
+"HCC15","Input","KEGG_OOCYTE_MEIOSIS",0.53585,1.69,0.0175,5147,0.245,"PPP2R1B, PTTG1, CDC25C, SLK, CDC23, ITPR1, INS, PLK1, CALM3, CHP1, ANAPC4, PPP2R5C, BUB1, CCNB1, BTRC, ADCY9, ADCY7, CALM1, PPP2R1A, PTTG2, CCNB2, ANAPC5, PPP2R5D, SKP1, SMC3, YWHAQ, CDK1, CDC20, FBXO5, MAP2K1, SMC1A, YWHAG, PRKACB, PPP1CC, PPP2R5A, ITPR3, PPP3R1, SGO1, ANAPC7, ESPL1, REC8, RPS6KA1, CDC27, PPP1CA, CCNE2, CDK2, IGF1R, PPP1CB, CALML6, YWHAZ, CUL1, ANAPC2, PPP2CB, CALM2, FBXW11, MAD2L2, PPP3CB",1.75696195131371,0.610833915635468,TRUE
+"HCC15","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.32405,1,0.433,2279,0.854,"FUCA1, FUCA2, MAN2C1",0.363512103646635,0.068542129310995,FALSE
+"HCC15","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.24662,0.775,0.781,4667,1,"NDUFS3, ATP6V0A4, ATP5F1B, ATP6V0E1, ATP6V1E1, ATP6V1C1, ATP6V0A1, ATP6V1H, NDUFA9, ATP6V0B, ATP5MG, TCIRG1, ATP6V0D1, NDUFV3, PPA1, ATP6V0C, COX5A, NDUFB10, ATP5PO, COX15, NDUFA2, ATP6V1A, COX7A2, NDUFB1, ATP6V0E2, ATP5F1C, NDUFS1, NDUFAB1, ATP5MC3, ATP5F1D, COX8A, ATP6V1G1, ATP6V0A2, ATP5MC2, CYC1, COX4I1, SDHD",0.1073489661227,0,FALSE
+"HCC15","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.30754,-1.18,0.229,14442,0.833,"GALNT3, GALNTL6, ST6GALNAC1, GALNT15, GALNT9, GALNT13, GCNT4, GCNT1, GALNT16, GALNT14, ST3GAL1, GALNT18, GALNT7",0.640164517660112,0.0793549985932124,FALSE
+"HCC15","Input","KEGG_P53_SIGNALING_PATHWAY",0.30407,0.96,0.515,4224,0.871,"CCND3, CASP9, APAF1, CCNB1, CCNB2, PMAIP1, CHEK1, EI24, ATM, CDK1, DDB2, CASP8, RRM2, SERPINB5, PIDD1, CCNG1, BID, SFN, COP1, FAS, CCNE2, CDK2",0.288192770958809,0.0599818449923368,FALSE
+"HCC15","Input","KEGG_PANCREATIC_CANCER",0.28222,0.892,0.618,4555,0.955,"EGF, CHUK, CASP9, SMAD2, MAPK8, E2F3, AKT1, ARAF, TGFA, RAD51, BCL2L1, IKBKG, MAP2K1, CDC42, E2F2, RELA, MAPK9, AKT2, RALB, TGFB1, TGFBR2, CDK6",0.209011524911184,0.0199966284162537,FALSE
+"HCC15","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.24745,0.784,0.795,2722,1,"BCAT1, PPCDC, COASY",0.0996328713435297,0,FALSE
+"HCC15","Input","KEGG_PARKINSONS_DISEASE",0.21586,0.685,0.894,4757,0.999,"NDUFS3, CASP9, VDAC2, APAF1, SLC18A2, ATP5F1B, PARK7, UCHL1, NDUFA9, UBE2J1, NDUFV3, COX5A, NDUFB10, UBE2G2, ATP5PO, NDUFA2, VDAC1, COX7A2, NDUFB1, ATP5F1C, NDUFS1, NDUFAB1, UBA1, ATP5MC3, ATP5F1D, COX8A, ATP5MC2, CYC1, COX4I1, SDHD, UBE2J2",0.0486624812040823,0.000434511774017692,FALSE
+"HCC15","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.43743,1.38,0.0931,5551,0.382,"TUBAL3, CD14, ROCK2, ARPC2, WASL, ARPC5L, KRT18, ABL1, YWHAQ, LY96, ARPC3, CDC42, NCL, TUBB3, ARPC4, ARPC1A, TUBB2A, YWHAZ, ITGB1, TUBA1C, TUBB, TUBA4A, CTTN, TUBA1B, EZR, PRKCA, CDH1",1.03105031901866,0.417936637088291,FALSE
+"HCC15","Input","KEGG_PATHWAYS_IN_CANCER",0.2259,0.705,0.887,5626,0.991,"FGF9, COL4A6, FGF19, CSF2RA, EGF, KIT, CHUK, CASP9, EGLN1, RASSF5, SMAD2, SLC2A1, AXIN2, BMP4, PPARD, MAPK8, TRAF2, MSH2, TPR, E2F3, ABL1, CKS1B, AKT1, CTNNA1, ARAF, TGFA, CUL2, FZD3, RAD51, NCOA4, HDAC1, BCL2L1, GLI2, EGLN3, CTBP2, IKBKG, APC, NFKBIA, MAP2K1, CBL, CDC42, CASP8, WNT3, MSH3, E2F2, MSH6, PIAS1, COL4A4, PTGS2, MTOR, RELA, SUFU, APPL1, LEF1, JUP, ITGA2, HRAS, DVL1, LAMB3, CXCL8, BID, HSP90AA1, MAPK9, AKT2, RALB, FAS, HSP90AB1, CCNE2, NRAS, CDK2, TGFB1, PML, IGF1R, TGFBR2, ELOC, SOS1, XIAP, CDK6, TPM3, ITGA6, ITGB1, FZD9, VHL, FGF3, FZD6, PIK3R1, CCDC6, RXRA, SOS2, BIRC5, ELOB, TCF7, PTEN, BIRC2, LAMA1, TCF7L2, TRAF6, TRAF3, PRKCA, CDH1, FZD1, HDAC2, CRK, BIRC3, CDKN1B, LAMB2",0.0520763801682736,0.00392634551472468,FALSE
+"HCC15","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.48286,1.52,0.0425,3070,0.353,"UGDH, RPEL1, GUSB, DCXR, RPE",1.37161106994969,0.452225294612177,FALSE
+"HCC15","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.53817,1.7,0.0224,3070,0.28,"PGD, TALDO1, G6PD, PFKP, RBKS, RPEL1, H6PD, GPI, TKT, ALDOA, RPE",1.64975198166584,0.552841968657781,FALSE
+"HCC15","Input","KEGG_PEROXISOME",0.28942,0.921,0.572,6744,0.929,"PRDX1, SCP2, SLC27A2, MPV17L, NUDT19, SOD1, DECR2, ABCD1, ACOX1, GNPAT, PEX6, PEX1, DHRS4, PECR, MPV17, PEX13, PEX14, PEX7, CRAT, GSTK1, FAR1, CROT, PEX16, PHYH, EPHX2, PEX3, ABCD3, ACSL3, SOD2, PEX11B, IDH1, PMVK, AGPS, ECI2, ACSL1",0.242603971206976,0.0319842860063582,FALSE
+"HCC15","Input","KEGG_PHENYLALANINE_METABOLISM",0.45266,1.41,0.0855,3387,0.384,"ALDH3A1, PAH, PRDX6, ALDH3B1, GOT2, MAOA",1.06803388527183,0.415668775632469,FALSE
+"HCC15","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.22546,0.714,0.872,5224,0.988,"ITPR1, SYNJ1, CALM3, DGKG, CALM1, IPPK, PLCD4, IMPA1, PIKFYVE, DGKD, PIK3C2A, INPP5A, ITPK1, ITPR3, ITPKA, ITPKB, PLCD3, IMPA2, CALML6, PIK3R1, CALM2, DGKA, CDIPT, INPP1, PTEN",0.0594835150674328,0.00524305541237188,FALSE
+"HCC15","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.39101,1.24,0.176,1990,0.499,"HMBS, EARS2, BLVRA, UROS, GUSB, BLVRB",0.75448733218585,0.30189945437661,FALSE
+"HCC15","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.2493,0.773,0.805,1391,1,"SCP2, SLC27A2, PDPK1, ME1, PPARD, PPARA, CYP27A1",0.0942041196321315,0,FALSE
+"HCC15","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.64526,2.03,0,1700,0.17,"CYP39A1, SCP2, CYP27A1, HSD3B7",Inf,0.769551078621726,TRUE
+"HCC15","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.25478,-0.927,0.535,11935,1,"CD79A, CD8B, TAP2, AICDA, AIRE, RFXAP, BTK, CD3D, IL2RG, CIITA, IGLL1, LCK, RAG1, BLNK, CD8A, JAK3, RFX5, IL7R, RFXANK",0.271646217978772,0,FALSE
+"HCC15","Input","KEGG_PRION_DISEASES",0.24516,0.779,0.784,3165,1,"CCL5, STIP1, SOD1, MAP2K1, PRKACB, C5",0.105683937315562,0,FALSE
+"HCC15","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.42902,1.36,0.103,4818,0.368,"PDE3A, CDC25C, CDC23, INS, PLK1, ANAPC4, BUB1, CCNB1, ADCY9, ADCY7, MAPK8, CCNB2, ANAPC5, MAPK14, AKT1, ARAF, CDK1, MAP2K1, PRKACB, MAPK13, CDC25B, ANAPC7, GNAI1, HSP90AA1, MAPK9, AKT2, RPS6KA1, CDC27, GNAI3, HSP90AB1, CDK2, IGF1R, CCNA2, PIK3R1, ANAPC2",0.987162775294828,0.434152181326482,FALSE
+"HCC15","Input","KEGG_PROPANOATE_METABOLISM",0.32908,1.04,0.41,5284,0.783,"HADHA, ALDH9A1, LDHA, HIBCH, MCEE, ALDH3A2, ACAT1, ALDH2, ACACA, ECHS1, ACSS2, LDHAL6B, ALDH7A1, ACACB, LDHB",0.387216143280265,0.106238237942057,FALSE
+"HCC15","Input","KEGG_PROSTATE_CANCER",0.23815,0.746,0.841,4450,1,"EGF, CHUK, PDPK1, INS, CASP9, E2F3, AKT1, ARAF, TGFA, IKBKG, NFKBIA, MAP2K1, CREB3L2, E2F2, MTOR, RELA, LEF1, HRAS, HSP90AA1, AKT2, HSP90AB1, CCNE2, NRAS, CDK2, IGF1R, SOS1",0.0752040042020878,0,FALSE
+"HCC15","Input","KEGG_PROTEASOME",0.48553,1.56,0.0378,4892,0.319,"PSMC6, PSMA6, PSMA1, PSMC1, PSMA4, PSMC3, PSMB1, PSMA5, PSMB2, PSME2, PSMD1, PSMD14, PSMD8, PSMD13, PSMC2, PSMD4, PSMB7, PSME1, PSMD12, PSME4, PSMA2, PSMD7",1.42250820016277,0.496209316942819,FALSE
+"HCC15","Input","KEGG_PROTEIN_EXPORT",0.4637,1.49,0.0644,5209,0.356,"SRP54, SEC11A, SEC63, SRP9, SRPRA, SRP72, SRP19, SRP68, SEC61A2, SRP14, SPCS2, SEC61B",1.19111413264019,0.448550002027125,FALSE
+"HCC15","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.20006,-0.709,0.84,11762,0.954,"ATP1B4, ATP1A4, SLC9A3, ATP1B3, PCK1, GLS, GLS2, ATP1B2, PCK2, ATP1A2, FXYD2, SLC4A4, AQP1, ATP1A3, CA2",0.0757207139381184,0.0204516252959049,FALSE
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diff --git a/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_venn_diagram.pdf b/Examples/cell_corr/Fig7_Coldren_transcr_NSCLC/GSEA/GSEA_venn_diagram.pdf
new file mode 100644
index 0000000..aae35d2
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diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_correlation_matrix.pdf b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_correlation_matrix.pdf
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diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_dot_plot.pdf b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_dot_plot.pdf
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diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_interactive_network.graph.html b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
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--- /dev/null
+++ b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_interactive_network.graph.html
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+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
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+  // See if we're running in Shiny mode. If not, it's a static document.
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+  var shinyMode = window.HTMLWidgets.shinyMode =
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+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
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+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-8ea37f318a15357928c0" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..3458a47
--- /dev/null
+++ b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv
@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"FGFR inhibitor",0.9162,0.857992940363897,0.030069198759245,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0959901345006666
+"ATPase inhibitor",0.6208,1.49135232016353,9.36310504510649e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H1299",3.88568859371919e-05
+"protein tyrosine kinase inhibitor",0.6128,0.905785783568215,0.42975713550261,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.699408671504247
+"glucocorticoid receptor agonist",0.609533333333333,1.18125840082677,0.0110787610049687,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0656812259580285
+"BCL inhibitor",0.606933333333333,0.83404483150031,0.621374511146836,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.904808498687498
+"calcium channel blocker",0.578066666666667,0.818715672490122,0.759004011802418,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"phosphatase inhibitor",0.575333333333333,0.768837124369996,0.911205326823615,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"progesterone receptor agonist",0.468066666666667,1.14279872410216,0.0656755076850518,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.175840875414816
+"cytochrome P450 inhibitor",0.3726,1.1258243836661,0.175618004518897,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.364407359376711
+"adenosine receptor antagonist",0.369466666666667,1.33455952426616,0.0157155933418918,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0726524699065228
+"src inhibitor",0.363466666666667,0.968520290123523,0.705556812894415,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.993713284596769
+"VEGFR inhibitor",0.338333333333333,0.697819733851359,0.999744184750522,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"serotonin receptor agonist",0.337866666666667,1.42384478822391,0.00245631728942153,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H2126",0.0169895279184989
+"PDGFR tyrosine kinase receptor inhibitor",0.3112,0.846028469632418,0.973925640038297,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"benzodiazepine receptor agonist",0.2956,0.80964011405421,0.989336976160413,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"TGF beta receptor inhibitor",0.2604,1.61097946249213,0.000159628756937528,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, A549, HCC44, H460",0.00220819780430246
+"PPAR receptor agonist",0.259066666666667,1.25642534123411,0.0188884801347523,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, HCC44",0.0825128342728654
+"acetylcholine receptor agonist",0.2202,1.14915895953768,0.196324898565245,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.370340149566257
+"acetylcholine receptor antagonist",0.1542,1.34633222391164,0.094513955260518,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC44",0.237716917776454
+"AP inhibitor",0.141,1.20999232583163,0.0911569327526555,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.2364382943272
+"FLT3 inhibitor",0.138866666666667,0.842242658168117,0.995129043207907,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"bromodomain inhibitor",0.1164,1.16407368446209,0.172228930458212,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.364407359376711
+"serotonin receptor antagonist",0.0993333333333334,1.07367191494999,0.573000690991427,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.849268881290866
+"adrenergic receptor antagonist",0.0945333333333333,0.837393052162199,0.997817061564008,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"adrenergic receptor agonist",0.0914666666666667,0.932426394388523,0.950570534799359,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"NFkB pathway inhibitor",0.0823999999999999,0.964384022502003,0.910804602844587,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"androgen receptor antagonist",0.0693333333333334,1.08415573911992,0.492402594028351,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.771121043478361
+"EGFR inhibitor",0.0512,1.28838870576502,0.0293665661422513,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.0959901345006666
+"KIT inhibitor",0.0461333333333334,0.930295334570592,0.950204433007134,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"DNA polymerase inhibitor",0.0448,1.10806705573264,0.422451367009864,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.699408671504247
+"tyrosine kinase inhibitor",0.00293333333333331,0.770198347984527,0.999934762693921,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"Abl kinase inhibitor",-0.00859999999999997,1.00071415927398,0.706374503508547,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.993713284596769
+"protein synthesis inhibitor",-0.0173333333333333,1.00338118854392,0.785356710220923,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"RAF inhibitor",-0.0584666666666667,1.31988662211498,0.0121810065390786,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0674015695162348
+"glutamate receptor antagonist",-0.0634000000000001,1.1067608336299,0.464871545786783,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.742006505775058
+"phosphodiesterase inhibitor",-0.0666,1.13532882587255,0.291083692199713,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.5140414138846
+"estrogen receptor antagonist",-0.0826666666666667,1.16114264330238,0.189565326907583,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.370340149566257
+"bacterial 50S ribosomal subunit inhibitor",-0.119266666666667,0.978222912564752,0.884785409782261,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"microtubule inhibitor",-0.126933333333333,0.99976643462837,0.787673271358329,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"sodium channel blocker",-0.133533333333333,0.736048607349374,0.999978508673811,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"growth factor receptor inhibitor",-0.1378,1.30802567689957,0.0091688665224188,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H460, H520",0.05853968625852
+"retinoid receptor agonist",-0.141133333333333,1.27462290595335,0.0291443526088252,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0959901345006666
+"sterol demethylase inhibitor",-0.146,1.37631033668179,0.00159271892090739,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H520",0.0120177882213921
+"CHK inhibitor",-0.154066666666667,1.28560777548246,0.0208896057538746,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0825636798843614
+"HCV inhibitor",-0.156066666666667,1.50097275442421,4.50015508622314e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC827, H1650, H1975, H1703",9.33782180391301e-05
+"AKT inhibitor",-0.162266666666667,1.10037769273403,0.422168329981753,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.699408671504247
+"histamine receptor antagonist",-0.193666666666667,1.27742920780464,0.0206568243558195,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0825636798843614
+"proteasome inhibitor",-0.213666666666667,1.37313659016068,0.000231270238480103,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00274220425626408
+"Bcr.Abl kinase inhibitor",-0.223266666666667,0.990674839740688,0.750415427964132,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.999978508673811
+"JAK inhibitor",-0.229266666666667,0.814583282304224,0.997966326380623,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"tubulin polymerization inhibitor",-0.2384,1.15621734239595,0.156532623304893,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.341900203534372
+"potassium channel blocker",-0.252666666666667,1.23499037975817,0.0300316428609227,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.0959901345006666
+"PI3K inhibitor",-0.263733333333333,0.846565115769659,0.989487270475967,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"RET tyrosine kinase inhibitor",-0.2872,1.12565709064274,0.210363880439205,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.388004490587868
+"antioxidant",-0.296066666666667,1.36460546190709,0.00102822113293202,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC44",0.00853423540333575
+"PLK inhibitor",-0.311933333333333,1.70990569776175,9.6191803046972e-10,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2126, HCC15, HCC44, H520",7.98391965289868e-08
+"ALK tyrosine kinase receptor inhibitor",-0.319066666666667,0.967549442565869,0.787528701789879,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"vitamin D receptor agonist",-0.326266666666667,1.23341630480239,0.0456398561504446,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.135289573588818
+"estrogen receptor agonist",-0.3272,0.857796612590321,0.96406610591418,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"HSP inhibitor",-0.327866666666667,1.12482727986292,0.125041034601526,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.280497455998019
+"glycogen synthase kinase inhibitor",-0.334466666666667,1.12353967866018,0.189849146947467,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.370340149566257
+"CDK inhibitor",-0.344066666666667,0.91582760906396,0.889024121628442,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"dopamine receptor antagonist",-0.352333333333333,0.856170182237376,0.947355559890469,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"p38 MAPK inhibitor",-0.3578,1.2308087468931,0.0157559573291254,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.0726524699065228
+"DNA inhibitor",-0.369466666666667,1.09348472238767,0.192163009166042,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.370340149566257
+"thymidylate synthase inhibitor",-0.376666666666667,1.49168493737148,1.67848050448913e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",4.64379606241994e-05
+"DNA alkylating agent",-0.394733333333333,1.00873403451106,0.507557488038412,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.780134657540523
+"mTOR inhibitor",-0.395333333333333,0.995020004584737,0.526227088623088,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.794124515558478
+"opioid receptor agonist",-0.398133333333333,1.06978681899491,0.220978230126144,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.398721589140651
+"ribonucleotide reductase inhibitor",-0.398266666666667,1.05213731224091,0.342529437351386,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.592290485420106
+"Aurora kinase inhibitor",-0.465533333333333,1.07604964480977,0.113999952027774,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.270342743380149
+"CC chemokine receptor antagonist",-0.469066666666667,1.13130673285786,0.0579335420765324,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.160282799745073
+"DNA synthesis inhibitor",-0.472866666666667,0.768688481084751,0.98134677846643,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"DNA methyltransferase inhibitor",-0.486133333333333,1.31521605322725,5.59832282417323e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H3255",0.000929321588812755
+"HDAC inhibitor",-0.4922,1.0863880653668,0.118991435765717,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.274341365793182
+"cyclooxygenase inhibitor",-0.503133333333333,0.757398259708539,0.971837038853256,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999978508673811
+"PARP inhibitor",-0.551266666666667,1.16695026621083,0.0150758992112059,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0726524699065228
+"bacterial DNA gyrase inhibitor",-0.6374,0.994741876066349,0.112998314978189,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.270342743380149
+"topoisomerase inhibitor",-0.645133333333333,1.1862686317469,0.0248656103112547,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.0938111661742792
+"MDM inhibitor",-0.6568,1.31819184599858,0.000910684996862495,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC15, H460",0.00839853941550968
+"HMGCR inhibitor",-0.758533333333333,1.05680433833506,0.0550640123102416,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H1975",0.157597000750002
+"MEK inhibitor",-0.835733333333333,1.07522459226411,0.0330433550493935,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC15",0.101577721077765
+"MET inhibitor",-0.849733333333333,1.08040855147265,0.00053522755950158,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00555298592982889
diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..97a7568
--- /dev/null
+++ b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/DMEA/DMEA_results.csv
@@ -0,0 +1,1246 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"HCC827","Pearson.est","EGFR inhibitor",-0.35603,-0.909,0.584,1008,0.942,"vandetanib, canertinib, OSI.420, BMS.599626, BIBX.1382, AEE788, afatinib, tyrphostin.AG.1478, lapatinib, osimertinib, pelitinib, PD.168393, WZ8040, PD.153035, TAK.285, erlotinib, icotinib, BIBU.1361",0.233587152887601,0.0259490972071227,FALSE
+"HCC827","Pearson.est","Abl kinase inhibitor",-0.26555,-0.659,0.873,991,0.92,"imatinib, KW.2449, bosutinib, tozasertib, bafetinib, metatinib",0.0589857562944303,0.0362121726544447,FALSE
+"HCC827","Pearson.est","acetylcholine receptor agonist",-0.29525,-0.742,0.766,1266,0.894,"tremorine",0.115771230367396,0.0486624812040823,FALSE
+"HCC827","Pearson.est","acetylcholine receptor antagonist",0.40178,1.05,0.386,200,1,"methscopolamine, hyoscyamine",0.413412695328245,0,FALSE
+"HCC827","Pearson.est","adenosine receptor antagonist",-0.38674,-0.949,0.523,860,0.916,"MRS.1220, sulmazole, CGS.15943",0.281498311132726,0.0381045263321496,FALSE
+"HCC827","Pearson.est","adrenergic receptor agonist",-0.34545,-0.86,0.602,1077,0.812,"oxymetazoline, metaraminol, buphenine, terbutaline, epinephrine, isoxsuprine",0.220403508742175,0.0904439707588247,FALSE
+"HCC827","Pearson.est","adrenergic receptor antagonist",0.32003,0.876,0.563,123,1,"atipamezole, dihydroergocristine, atenolol......, metoprolol",0.249491605148654,0,FALSE
+"HCC827","Pearson.est","AKT inhibitor",-0.47425,-1.17,0.277,1041,0.697,"GDC.0068, AZD5363, CCT128930, uprosertib, palomid.529, triciribine",0.557520230935551,0.156767221901991,FALSE
+"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.49651,-1.23,0.244,980,0.631,"alectinib, NVP.TAE684, AZD3463, lorlatinib, CEP.37440, GW.788388",0.612610173661271,0.199970640755866,FALSE
+"HCC827","Pearson.est","androgen receptor antagonist",0.25589,0.684,0.856,1079,1,"RU.58841, enzalutamide, nilutamide, flutamide, bicalutamide, cyproterone.acetate",0.0675262353228468,0,FALSE
+"HCC827","Pearson.est","antioxidant",0.42014,1.16,0.286,22,1,"trolox",0.543633966870957,0,FALSE
+"HCC827","Pearson.est","AP inhibitor",-0.48231,-1.24,0.212,1326,0.681,"LCL.161, embelin",0.673664139071249,0.166852888087215,FALSE
+"HCC827","Pearson.est","ATPase inhibitor",0.67635,1.87,0.0199,283,0.534,"k.strophanthidin, oligomycin.a, evodiamine, digoxin, blebbistatin...., NMS.873, digitoxin",1.70114692359029,0.272458742971444,FALSE
+"HCC827","Pearson.est","Aurora kinase inhibitor",-0.23431,-0.578,0.938,940,0.975,"MK.8745, AMG900, hesperadin, KW.2449, alisertib, tozasertib, ZM.447439, PF.03814735, MLN.8054",0.0277971616209356,0.0109953843014632,FALSE
+"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.35155,0.937,0.513,105,1,"josamycin, radezolid",0.289882634888184,0,FALSE
+"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.34028,-0.851,0.621,1395,0.788,"novobiocin",0.20690839982342,0.103473782510445,FALSE
+"HCC827","Pearson.est","BCL inhibitor",0.42712,1.17,0.245,364,1,"TW.37, ABT.737, gossypol, obatoclax, venetoclax",0.610833915635468,0,FALSE
+"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.28335,-0.702,0.842,991,0.907,"imatinib, bosutinib, tozasertib, bafetinib, metatinib",0.0746879085003505,0.0423927129399047,FALSE
+"HCC827","Pearson.est","benzodiazepine receptor agonist",-0.18815,-0.475,0.989,270,1,"temazepam, gamma.aminobutyric.acid, bentazepam, eprinomectin, CL.218872, lorazepam, nefiracetam, ivermectin, ZK.93423, piperazine, indiplon, zaleplon, CGS.20625",0.0048037084028206,0,FALSE
+"HCC827","Pearson.est","bromodomain inhibitor",-0.35445,-0.867,0.632,1171,0.843,"JQ1....",0.199282921717615,0.0741724253752577,FALSE
+"HCC827","Pearson.est","calcium channel blocker",0.46778,1.3,0.169,74,1,"carboxyamidotriazole, efonidipine.monoethanolate",0.772113295386326,0,FALSE
+"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.34913,-0.879,0.59,1442,0.866,"navarixin",0.229147988357856,0.0624821079826534,FALSE
+"HCC827","Pearson.est","CDK inhibitor",-0.38755,-0.972,0.487,1224,0.899,"kenpaullone, PHA.793887, arcyriaflavin.a, alvocidib, AZD5438",0.312471038785366,0.0462403082667712,FALSE
+"HCC827","Pearson.est","CHK inhibitor",-0.65198,-1.64,0.0435,1146,0.584,"SCH.900776, LY2606368, LY2603618",1.36151074304536,0.233587152887601,FALSE
+"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.39783,-0.989,0.471,952,0.894,"ketoprofen, suxibuzone, acetylsalicylsalicylic.acid, FR.122047, meloxicam, AM.404, ramifenazone, aspirin, curcumin, indoprofen, amfenac, FK.3311",0.326979092871104,0.0486624812040823,FALSE
+"HCC827","Pearson.est","cytochrome P450 inhibitor",-0.30142,-0.757,0.764,1302,0.894,"cobicistat",0.11690664142431,0.0486624812040823,FALSE
+"HCC827","Pearson.est","DNA alkylating agent",-0.43531,-1.09,0.35,929,0.709,"ifosfamide, estramustine, satraplatin, dianhydrogalactitol, melphalan, streptozotocin, TH.302, dacarbazine",0.455931955649724,0.149353764816933,FALSE
+"HCC827","Pearson.est","DNA inhibitor",-0.28137,-0.708,0.807,1287,0.92,"melphalan, nithiamide, busulfan",0.0931264652779296,0.0362121726544447,FALSE
+"HCC827","Pearson.est","DNA methyltransferase inhibitor",-0.6256,-1.54,0.0501,1273,0.349,"fdcyd, decitabine, azacitidine",1.30016227413275,0.45717457304082,FALSE
+"HCC827","Pearson.est","DNA polymerase inhibitor",0.28047,0.755,0.74,47,1,"menadione",0.130768280269024,0,FALSE
+"HCC827","Pearson.est","DNA synthesis inhibitor",-0.36941,-0.933,0.519,1301,0.921,"anisomycin, floxuridine, altretamine",0.284832642151542,0.0357403698031511,FALSE
+"HCC827","Pearson.est","dopamine receptor antagonist",-0.34568,-0.878,0.602,1204,0.844,"oxiperomide, acetophenazine, amisulpride, isofloxythepin",0.220403508742175,0.073657553374345,FALSE
+"HCC827","Pearson.est","estrogen receptor agonist",0.25796,0.702,0.808,199,1,"erteberel, estrone",0.0925886392254138,0,FALSE
+"HCC827","Pearson.est","estrogen receptor antagonist",-0.42994,-1.09,0.375,1411,0.709,"raloxifene",0.425968732272281,0.149353764816933,FALSE
+"HCC827","Pearson.est","FGFR inhibitor",0.41475,1.14,0.277,260,0.989,"erdafitinib, dovitinib, lenvatinib, nintedanib",0.557520230935551,0.0048037084028206,FALSE
+"HCC827","Pearson.est","FLT3 inhibitor",0.27451,0.756,0.738,201,1,"GTP.14564, ponatinib, ENMD.2076, dovitinib, TG.101348",0.131943638176958,0,FALSE
+"HCC827","Pearson.est","glucocorticoid receptor agonist",0.66188,1.74,0.0274,328,0.542,"hydrocortisone, triamcinolone, beclomethasone.dipropionate, halcinonide, dexamethasone.acetate, triamcinolone.acetonide, desonide, betamethasone, deflazacort, flumethasone.pivalate, clobetasol.propionate, ciclesonide, fluocinolone.acetonide, methylprednisolone, rimexolone, piretanide, prednisolone.hemisuccinate, fluticasone.propionate",1.56224943717961,0.266000713461613,FALSE
+"HCC827","Pearson.est","glutamate receptor antagonist",-0.36112,-0.884,0.608,910,0.88,"IEM1754, ACDPP, LY456236, latrepirdine, MTPG, SIB.1757, diazooxonorleucine",0.216096420727265,0.0555173278498314,FALSE
+"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.64259,-1.58,0.0549,1224,0.416,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, AZD2858",1.26042765554991,0.380906669373257,FALSE
+"HCC827","Pearson.est","growth factor receptor inhibitor",0.25399,0.706,0.819,1082,1,"PHA.848125, GSK1904529A, lestaurtinib, danusertib, GSK1838705A, GW.441756, AZD3463",0.0867160982395816,0,FALSE
+"HCC827","Pearson.est","HCV inhibitor",-0.72311,-1.81,0.00598,1149,0.248,"PSI.7976, daclatasvir, Ro.9187, embelin",2.22329881601159,0.605548319173784,TRUE
+"HCC827","Pearson.est","HDAC inhibitor",-0.56356,-1.42,0.117,1104,0.467,"givinostat, vorinostat, nexturastat.a, entinostat, M.344, dacinostat, R306465, romidepsin, panobinostat, PCI.24781, SB.939, tacedinaline, JNJ.26481585",0.931814138253838,0.330683119433888,FALSE
+"HCC827","Pearson.est","histamine receptor antagonist",-0.54969,-1.37,0.13,1076,0.498,"cyproheptadine, ICI.162846, pheniramine, terfenadine, levocetirizine, tiotidine, ranitidine, tecastemizole, zolantidine, chloropyramine",0.886056647693163,0.302770657240282,FALSE
+"HCC827","Pearson.est","HMGCR inhibitor",-0.48065,-1.22,0.227,1237,0.62,"mevastatin, simvastatin",0.643974142806877,0.207608310501746,FALSE
+"HCC827","Pearson.est","HSP inhibitor",-0.65283,-1.63,0.0388,1108,0.464,"alvespimycin, tanespimycin, SNX.5422, BIIB021, SNX.2112, XL888, NVP.AUY922, VER.49009, PU.H71",1.41116827440579,0.333482019445119,FALSE
+"HCC827","Pearson.est","JAK inhibitor",0.25639,0.695,0.834,203,1,"AT.9283, filgotinib, TG.101209, TG.101348, AZ960",0.0788339493622613,0,FALSE
+"HCC827","Pearson.est","KIT inhibitor",-0.17949,-0.452,0.991,919,0.992,"KI.8751, imatinib, vatalanib, sunitinib, tandutinib, telatinib",0.00392634551472468,0.00348832784582135,FALSE
+"HCC827","Pearson.est","MDM inhibitor",-0.34106,-0.862,0.581,1124,0.83,"serdemetan, RITA",0.235823867609669,0.0809219076239261,FALSE
+"HCC827","Pearson.est","MEK inhibitor",-0.54892,-1.37,0.144,1050,0.498,"arctigenin, AS.703026, AZD8330, PD.184352, cobimetinib, MEK162, trametinib, Ro.4987655, TAK.733, BIX.02188, nobiletin",0.84163750790475,0.302770657240282,FALSE
+"HCC827","Pearson.est","MET inhibitor",-0.60793,-1.46,0.0763,1045,0.427,"LY2801653, PF.04217903, AMG458, INC.280",1.11747546204512,0.369572124974976,FALSE
+"HCC827","Pearson.est","microtubule inhibitor",-0.35709,-0.9,0.549,1200,0.93,"cabazitaxel, podophyllotoxin",0.260427655549908,0.0315170514460649,FALSE
+"HCC827","Pearson.est","mTOR inhibitor",0.18114,0.492,0.975,286,1,"voxtalisib, torin.1, XL388, PF.04691502, OSI.027, WYE.125132, WYE.354, AZD2014",0.0109953843014632,0,FALSE
+"HCC827","Pearson.est","NFkB pathway inhibitor",0.35786,0.961,0.471,49,1,"EVP4593, tyloxapol",0.326979092871104,0,FALSE
+"HCC827","Pearson.est","opioid receptor agonist",-0.35867,-0.896,0.579,1389,0.909,"salvinorin.a",0.237321436272564,0.0414361167780325,FALSE
+"HCC827","Pearson.est","p38 MAPK inhibitor",-0.64396,-1.6,0.044,1268,0.446,"TAK.715, VX.702, CMPD.1",1.35654732351381,0.350665141287858,FALSE
+"HCC827","Pearson.est","PARP inhibitor",-0.58796,-1.48,0.0863,897,0.428,"E7449, AZD2461, talazoparib, olaparib, PJ.34, niraparib",1.06398920428479,0.368556230986828,FALSE
+"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.19394,0.529,0.963,375,1,"dasatinib, ponatinib, dovitinib, lenvatinib, axitinib, nintedanib, motesanib, masitinib, linifanib, pazopanib",0.0163737128754655,0,FALSE
+"HCC827","Pearson.est","phosphatase inhibitor",0.38189,1.02,0.395,47,1,"GSK2830371, menadione",0.40340290437354,0,FALSE
+"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.51667,-1.32,0.165,1037,0.572,"cilostamide, papaverine, EMD.53998, GSK256066, zardaverine, YM.976",0.782516055786094,0.242603971206976,FALSE
+"HCC827","Pearson.est","PI3K inhibitor",0.20965,0.562,0.936,241,1,"voxtalisib, buparlisib, ZSTK.474, PF.04691502, PI.828, GDC.0941, idelalisib",0.0287241512618947,0,FALSE
+"HCC827","Pearson.est","PLK inhibitor",0.30049,0.811,0.644,1015,1,"volasertib, NMS.1286937, GW.843682X, rigosertib, HMN.214, GSK461364, BI.2536",0.191114132640188,0,FALSE
+"HCC827","Pearson.est","potassium channel blocker",-0.52176,-1.29,0.18,1175,0.602,"oleoylethanolamide, meglitinide",0.744727494896694,0.220403508742175,FALSE
+"HCC827","Pearson.est","PPAR receptor agonist",0.18876,0.503,0.984,1176,1,"clofibrate, fenofibrate, pterostilbene, S26948, ciprofibrate, GW.501516, oleoylethanolamide",0.00700490156865849,0,FALSE
+"HCC827","Pearson.est","progesterone receptor agonist",0.54686,1.49,0.103,26,0.976,"norethindrone, tanaproget",0.987162775294828,0.0105501823333082,FALSE
+"HCC827","Pearson.est","proteasome inhibitor",-0.72327,-1.82,0.00633,1170,0.47,"carfilzomib, bortezomib, ONX.0914, delanzomib, ixazomib, ixazomib.citrate",2.19859628998264,0.327902142064283,FALSE
+"HCC827","Pearson.est","protein synthesis inhibitor",0.2476,0.652,0.865,191,1,"clofoctol, clindamycin.phosphate, harringtonine, florfenicol",0.0629838925351858,0,FALSE
+"HCC827","Pearson.est","protein tyrosine kinase inhibitor",0.36425,0.973,0.472,114,1,"mubritinib, PP.121",0.326058001365912,0,FALSE
+"HCC827","Pearson.est","RAF inhibitor",-0.61835,-1.54,0.0602,1296,0.349,"LGX818, GDC.0879, CEP.32496, vemurafenib, dabrafenib",1.22040350874218,0.45717457304082,FALSE
+"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.46037,-1.15,0.298,1008,0.709,"vandetanib, sunitinib, apatinib",0.525783735923745,0.149353764816933,FALSE
+"HCC827","Pearson.est","retinoid receptor agonist",-0.341,-0.858,0.612,1215,0.796,"tamibarotene, AM.580, CD.437",0.213248577854439,0.0990869322623309,FALSE
+"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.45848,-1.13,0.328,1211,0.688,"gemcitabine, fludarabine.phosphate, clofarabine, fludarabine",0.484126156288321,0.162411561764489,FALSE
+"HCC827","Pearson.est","serotonin receptor agonist",0.4792,1.29,0.179,179,0.946,"NAN.190, zolmitriptan, aripiprazole",0.747146969020107,0.0241088635982073,FALSE
+"HCC827","Pearson.est","serotonin receptor antagonist",0.29723,0.812,0.637,179,1,"pirenperone, SB.200646, aripiprazole",0.19586056766465,0,FALSE
+"HCC827","Pearson.est","sodium channel blocker",0.24279,0.693,0.839,90,1,"cibenzoline, oxcarbazepine",0.0762380391712997,0,FALSE
+"HCC827","Pearson.est","src inhibitor",-0.26735,-0.669,0.871,1032,0.927,"bosutinib, PP.2, saracatinib, KX2.391",0.0599818449923368,0.0329202658555029,FALSE
+"HCC827","Pearson.est","sterol demethylase inhibitor",0.47349,1.29,0.195,197,0.946,"posaconazole, sulconazole, chlormidazole, terconazole",0.709965388637482,0.0241088635982073,FALSE
+"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.4683,-1.14,0.3,1191,0.697,"repsox, D.4476, LY2109761",0.522878745280338,0.156767221901991,FALSE
+"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.61796,-1.57,0.0651,1250,0.38,"carmofur, raltitrexed, doxifluridine",1.18641901143181,0.42021640338319,FALSE
+"HCC827","Pearson.est","topoisomerase inhibitor",-0.49626,-1.23,0.239,1183,0.631,"amsacrine, etoposide, nemorubicin, rubitecan, SN.38, irinotecan, licochalcone.a, camptothecin, exatecan.mesylate, genz.644282",0.621602099051862,0.199970640755866,FALSE
+"HCC827","Pearson.est","tubulin polymerization inhibitor",-0.35576,-0.885,0.613,1089,0.904,"epothilone.d, fosbretabulin, KX2.391, plinabulin, taltobulin, mebendazole, podophyllotoxin, combretastatin.A.4",0.212539525481585,0.0438315695246367,FALSE
+"HCC827","Pearson.est","tyrosine kinase inhibitor",0.22136,0.599,0.932,133,1,"mubritinib, GTP.14564, PP.121, dasatinib",0.0305840876460186,0,FALSE
+"HCC827","Pearson.est","VEGFR inhibitor",0.12888,0.343,1,375,1,"SAR131675, ENMD.2076, dovitinib, lenvatinib, axitinib, ZM.306416, nintedanib, semaxanib, motesanib, linifanib, cediranib, pazopanib",0,0,FALSE
+"HCC827","Pearson.est","vitamin D receptor agonist",-0.34162,-0.844,0.627,1029,0.781,"maxacalcitol, calcitriol, ercalcitriol",0.202732459169284,0.1073489661227,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",-0.20296,-0.494,0.974,754,1,"afatinib, gefitinib, vandetanib, dacomitinib, osimertinib, PD.153035, neratinib, brigatinib, tucatinib, tyrphostin.AG.494, GW.583340, BIBU.1361, erlotinib, lapatinib, OSI.420, WZ8040, TAK.285, CP.724714, AEE788, BIBX.1382, tyrphostin.AG.1478, BMS.599626",0.0114410431213845,0,FALSE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.27828,-0.684,0.838,1301,0.987,"imatinib, tozasertib",0.0767559813697235,0.00568284733036327,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.49968,1.37,0.144,5,0.47,"xanomeline",0.84163750790475,0.327902142064283,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.52214,-1.27,0.203,1096,0.722,"hyoscyamine, darifenacin, diphemanil",0.692503962086787,0.141462802430361,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",0.4387,1.21,0.228,55,0.668,"MRS.1220",0.642065152999546,0.175223537524454,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",-0.39216,-0.956,0.509,1162,0.826,"clenbuterol, methyldopa, buphenine, terbutaline, metaraminol, epinephrine",0.293282217663241,0.0830199526796178,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",-0.27303,-0.677,0.844,1091,0.978,"levobunolol, imiloxan, dihydroergocristine, dronedarone, propranolol, vincamine",0.073657553374345,0.00966114521239857,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.47681,-1.19,0.269,1342,0.827,"ONC201, triciribine, uprosertib",0.570247719997592,0.0824944904474534,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.45458,-1.12,0.327,773,0.739,"SB.505124, DMH1, lorlatinib, brigatinib, AZD3463, CEP.37440, crizotinib, GW.788388",0.485452247339714,0.131355561605174,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",-0.59334,-1.47,0.082,1140,0.826,"enzalutamide, cyproterone.acetate, bicalutamide",1.08618614761628,0.0830199526796178,FALSE
+"HCC95","Pearson.est","antioxidant",0.38781,1.04,0.4,202,0.763,"trolox, benfotiamine",0.397940008672038,0.11747546204512,FALSE
+"HCC95","Pearson.est","AP inhibitor",0.3667,1.02,0.415,2,0.731,"idronoxil",0.381951903287907,0.13608262304214,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",0.69862,1.91,0.0199,213,0.293,"k.strophanthidin, blebbistatin...., NMS.873, evodiamine, digitoxigenin, ouabain",1.70114692359029,0.533132379645891,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",-0.28191,-0.676,0.842,1219,0.962,"barasertib, hesperadin, MLN.8054, PF.03814735, tozasertib",0.0746879085003505,0.0168249279621871,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42666,-1.04,0.418,964,0.79,"dirithromycin, valnemulin, tedizolid, azalomycin.b, azithromycin",0.378823718224965,0.102372908709559,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",-0.43578,-1.08,0.377,1361,0.806,"lomefloxacin, novobiocin",0.423658649794207,0.0936649581949093,FALSE
+"HCC95","Pearson.est","BCL inhibitor",0.29661,0.834,0.67,217,0.912,"ABT.737, gossypol, TW.37",0.173925197299174,0.0400051616715838,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.34726,-0.849,0.635,1301,0.871,"imatinib, tozasertib",0.197226274708024,0.0599818449923368,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.30379,-0.748,0.762,940,0.94,"CL.218872, lorazepam, bentazepam, ivermectin, eprinomectin, zaleplon",0.1180450286604,0.0268721464003014,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",0.53235,1.45,0.116,267,0.423,"PFI.1, OTX015, bromosporine",0.935542010773082,0.373659632624958,FALSE
+"HCC95","Pearson.est","calcium channel blocker",-0.26099,-0.637,0.882,1419,0.985,"penfluridol",0.0545314148681803,0.00656376950238827,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.54634,-1.34,0.159,994,0.832,"MK.0812, ZK811752, RS.504393, PF.04136309, navarixin",0.798602875679548,0.0798766737092761,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.35431,-0.871,0.606,1063,0.869,"BMS.265246, JNJ.7706621, BMS.387032, indisulam, R547, alvocidib, AZD5438, PHA.793887",0.217527375833714,0.0609802235513335,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.58405,-1.43,0.0891,918,0.757,"PF.477736, LY2606368, SB.218078, LY2603618, CHIR.124, SCH.900776",1.05012229596313,0.120904120499927,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.46292,-1.15,0.28,1113,0.752,"phenazone, acetylsalicylsalicylic.acid, indoprofen, ramifenazone, FK.3311, curcumin, aspirin, amfenac, meloxicam",0.552841968657781,0.123782159408358,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.39374,1.11,0.292,247,0.781,"morin, eplerenone, metyrapone, itraconazole",0.534617148551582,0.1073489661227,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.51026,-1.25,0.204,1157,0.739,"carboplatin, dianhydrogalactitol, melphalan, cyclophosphamide, mitomycin.c, dacarbazine",0.690369832574101,0.131355561605174,FALSE
+"HCC95","Pearson.est","DNA inhibitor",-0.62402,-1.54,0.052,1157,0.845,"carboplatin, valrubicin, melphalan, tirapazamine, sangivamycin, nimorazole, busulfan, nithiamide",1.2839966563652,0.0731432910503077,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.51536,-1.27,0.193,1313,0.722,"fdcyd, azacitidine",0.714442690992226,0.141462802430361,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",-0.35947,-0.878,0.611,1065,0.875,"idoxuridine, famciclovir, trifluridine, foscarnet",0.213958789757446,0.0579919469776868,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.38385,-0.939,0.553,1109,0.84,"CB.10.277, cyclocytidine, enocitabine, mitomycin.c, floxuridine, altretamine",0.257274868695302,0.0757207139381184,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",-0.54394,-1.3,0.171,1266,0.833,"domperidone, isofloxythepin, lurasidone, amisulpride, oxiperomide",0.767003889607846,0.0793549985932124,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.46089,-1.15,0.29,1341,0.752,"equol, PPT",0.537602002101044,0.123782159408358,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",-0.23461,-0.57,0.944,734,1,"tamoxifen, danazol, clomifene, raloxifene",0.025028005701931,0,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",0.2886,0.826,0.638,1033,0.866,"erdafitinib, PD.173074, orantinib, nintedanib, MK.2461, dovitinib, regorafenib, AZD4547, lenvatinib, lucitanib",0.195179321278838,0.0624821079826534,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",-0.41208,-1.02,0.418,1283,0.785,"sunitinib, tozasertib, pacritinib, tandutinib",0.378823718224965,0.105130343254747,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",0.58663,1.63,0.0502,234,0.532,"deflazacort, prednisolone.hemisuccinate, flumethasone.pivalate, triamcinolone.acetonide, beclomethasone.dipropionate, triamcinolone, dexamethasone.acetate, desonide, ciclesonide, betamethasone, fluocinolone.acetonide, rimexolone, halcinonide, piretanide",1.29929628285498,0.274088367704952,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",-0.41429,-0.999,0.463,1128,0.784,"SIB.1757, tiletamine, latrepirdine, CPP, diazooxonorleucine",0.334419008982047,0.105683937315562,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.20222,0.563,0.95,1157,1,"indirubin, TWS.119, CHIR.99021, GSK.3.inhibitor.IX, LY2090314, kenpaullone, tideglusib, CHIR.98014, AZD2858",0.0222763947111523,0,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.33695,-0.824,0.676,1015,0.875,"AZD3463, GW.441756, GSK1838705A",0.170053304058364,0.0579919469776868,FALSE
+"HCC95","Pearson.est","HCV inhibitor",-0.59201,-1.44,0.0858,1150,0.823,"PSI.7976, embelin, Ro.9187, daclatasvir",1.06651271215129,0.0846001647877302,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.24604,-0.611,0.913,1018,0.993,"chidamide, romidepsin, M.344, dacinostat, tacedinaline, SB.939, JNJ.26481585, vorinostat",0.039529222465701,0.00305075150461883,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",-0.3985,-0.98,0.483,1012,0.8,"tecastemizole, nizatidine, astemizole, levocetirizine, tiotidine, terfenadine, chloropyramine, zolantidine",0.316052869248488,0.0969100130080564,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.25312,0.699,0.836,1083,0.969,"lovastatin, pitavastatin, atorvastatin, fluvastatin, simvastatin, mevastatin",0.0777937225609836,0.0136762229492347,FALSE
+"HCC95","Pearson.est","HSP inhibitor",-0.21365,-0.522,0.963,768,1,"SNX.2112, tanespimycin, BIIB021, NVP.AUY922, guanidine, PU.H71, VER.49009",0.0163737128754655,0,FALSE
+"HCC95","Pearson.est","JAK inhibitor",-0.41458,-1.04,0.429,1378,0.79,"atiprimod, LY2784544, tozasertib, pacritinib",0.367542707815276,0.102372908709559,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.34217,-0.842,0.652,1283,0.865,"sunitinib, imatinib, tandutinib",0.18575240426808,0.0629838925351858,FALSE
+"HCC95","Pearson.est","MDM inhibitor",-0.32242,-0.79,0.715,685,0.894,"RITA, CGM097, idasanutlin, nutlin.3",0.145693958198919,0.0486624812040823,FALSE
+"HCC95","Pearson.est","MEK inhibitor",-0.56398,-1.4,0.104,1085,0.777,"TAK.733, arctigenin, PD.198306, Ro.4987655, nobiletin, AS.703026, BIX.02188, cobimetinib, MEK162, PD.98059, trametinib, PD.0325901",0.98296666070122,0.109578981199086,FALSE
+"HCC95","Pearson.est","MET inhibitor",-0.65095,-1.58,0.0374,976,1,"LY2801653, NVP.BVU972, INC.280, PF.04217903, AMG458",1.42712839779952,0,FALSE
+"HCC95","Pearson.est","microtubule inhibitor",0.2427,0.69,0.814,1099,0.927,"cytochalasin.b, estramustine.phosphate, cabazitaxel, vinblastine, colchicine, podophyllotoxin, secnidazole, triclabendazole, D.64131, vinflunine",0.0893755951107988,0.0329202658555029,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.42542,-1.04,0.439,1118,0.79,"NVP.BEZ235, GSK2126458, AZD8055, PP242, LY303511, GDC.0980, ku.0063794, sirolimus, PI.103",0.357535479757879,0.102372908709559,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",-0.34895,-0.853,0.66,1199,0.883,"parthenolide...., betulinic.acid, curcumin, bortezomib",0.180456064458131,0.0540392964224314,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",-0.42807,-1.05,0.405,1194,0.847,"BW.180C, salvinorin.a",0.392544976785331,0.0721165896692931,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",-0.6211,-1.5,0.0658,895,0.845,"CMPD.1, SB.239063, talmapimod, skepinone.l, SB.242235, VX.702, TAK.715",1.18177410638604,0.0731432910503077,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.4096,-1,0.476,1207,0.803,"PJ.34, olaparib, niraparib",0.322393047279507,0.095284454721319,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37793,-0.921,0.557,1283,0.835,"sunitinib, imatinib, trapidil, tandutinib",0.254144804826271,0.0783135245163979,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.56844,1.59,0.0802,156,0.418,"GSK2830371, menadione, CID.5458317, bis.maltolato.oxovanadium.IV.",1.09582563171584,0.378823718224965,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.27929,0.79,0.692,9,0.876,"avanafil",0.159893905543242,0.0574958938319193,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.38503,-0.931,0.545,1118,0.836,"NVP.BEZ235, GSK2126458, pilaralisib, alpelisib, taselisib, LY303511, GDC.0980, PI.103, TG.100713, CH5132799",0.263603497723358,0.0777937225609836,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.46842,-1.16,0.304,921,0.793,"NMS.1286937, GW.843682X, GSK461364, BI.2536",0.517126416391246,0.100726812682396,FALSE
+"HCC95","Pearson.est","potassium channel blocker",-0.54978,-1.36,0.148,1202,0.837,"meglitinide, oleoylethanolamide",0.829738284605043,0.07727454200674,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.30971,0.864,0.591,143,0.92,"pterostilbene, fenofibrate",0.228412519118745,0.0362121726544447,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",0.52377,1.45,0.109,68,0.423,"norethindrone, tanaproget",0.962573502059376,0.373659632624958,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",-0.63877,-1.57,0.0576,946,0.942,"ixazomib.citrate, MG.132, ONX.0914, delanzomib, ixazomib, carfilzomib, bortezomib",1.23957751657679,0.0259490972071227,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",0.19637,0.537,0.974,1167,0.968,"clindamycin.phosphate, methacycline, clofoctol, azomycin..2.nitroimidazole., chloramphenicol.palmitate, cycloheximide, harringtonine, anguidine, florfenicol, emetine, tedizolid.phosphate, mercaptopurine, thiostrepton, bruceantin, puromycin, brefeldin.a, homoharringtonine",0.0114410431213845,0.0141246426916063,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",0.39364,1.09,0.345,52,0.734,"PP.121, mubritinib",0.462180904926726,0.134303940083929,FALSE
+"HCC95","Pearson.est","RAF inhibitor",-0.47975,-1.18,0.255,1101,0.812,"LGX818, SB.590885, CEP.32496, vemurafenib, dabrafenib, AZ.628",0.593459819566045,0.0904439707588247,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.51892,-1.27,0.188,1283,0.722,"sunitinib, apatinib",0.72584215073632,0.141462802430361,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.33142,-0.816,0.697,986,0.871,"adapalene, bexarotene, tamibarotene, AM.580, CD.437",0.156767221901991,0.0599818449923368,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.45344,-1.12,0.33,887,0.739,"cladribine, LY2334737, clofarabine, fludarabine, fludarabine.phosphate",0.481486060122112,0.131355561605174,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.5081,-1.24,0.202,1090,0.726,"zolmitriptan, aripiprazole",0.694648630553376,0.139063379299906,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",-0.47447,-1.17,0.296,1264,0.803,"SB.216641, lurasidone, aripiprazole, RS.16566",0.528708288941061,0.095284454721319,FALSE
+"HCC95","Pearson.est","sodium channel blocker",-0.35591,-0.881,0.588,1138,0.89,"triamterene, brivaracetam, butamben, lappaconite, ajmaline",0.230622673923862,0.0506099933550872,FALSE
+"HCC95","Pearson.est","src inhibitor",0.32758,0.877,0.559,122,0.967,"ZM.306416, TG.100572, masitinib",0.252588192113577,0.0145735259169983,FALSE
+"HCC95","Pearson.est","sterol demethylase inhibitor",-0.4165,-1.02,0.434,1235,0.785,"ketoconazole, lanoconazole",0.362510270487489,0.105130343254747,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.53143,-1.28,0.194,1176,0.84,"repsox, D.4476, LY2109761",0.712198270069774,0.0757207139381184,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.75859,-1.83,0.00577,1211,0.38,"trifluridine, raltitrexed, carmofur, doxifluridine",2.23882418684427,0.42021640338319,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",-0.46406,-1.12,0.313,825,0.739,"TAS.103, teniposide, dexrazoxane, beta.lapachone, etoposide, camptothecin, rubitecan, idarubicin, amonafide, valrubicin, SN.38, topotecan, amsacrine, irinotecan, licochalcone.a, genz.644282, exatecan.mesylate",0.504455662453552,0.131355561605174,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.14709,-0.358,1,588,1,"albendazole, vincristine, vinorelbine, flubendazole, docetaxel, taltobulin, ABT.751, BNC105, plinabulin, paclitaxel, fosbretabulin, podophyllotoxin, indibulin, combretastatin.A.4, epothilone.b, KX2.391, oxibendazole, mebendazole",0,0,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.2927,-0.715,0.809,1404,0.967,"apatinib, AMG.208, BMS.599626",0.0920514783877277,0.0145735259169983,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.14312,-0.348,0.999,858,0.999,"cabozantinib, vatalanib, ENMD.2076, linifanib, lenvatinib, lucitanib, OSI.930, golvatinib, foretinib, tivozanib, MGCD.265, AEE788, sunitinib",0.000434511774017692,0.000434511774017692,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",-0.53272,-1.31,0.154,1397,0.865,"maxacalcitol, ercalcitriol",0.812479279163537,0.0629838925351858,FALSE
+"H1650","Pearson.est","EGFR inhibitor",-0.4296,-1.09,0.358,1059,0.931,"ARRY.334543, CNX.2006, gefitinib, tyrphostin.AG.494, WZ.4002, canertinib, OSI.420, afatinib, TAK.285, BMS.599626, osimertinib, PD.153035, BIBX.1382, icotinib, tyrphostin.AG.1478, rociletinib, pelitinib, vandetanib, erlotinib, PD.168393, BIBU.1361, WZ8040",0.446116973356126,0.0310503190186574,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",0.31755,0.87,0.576,992,0.891,"GZD824, KW.2449, ponatinib, imatinib, bafetinib, tozasertib, dasatinib, metatinib, flumatinib, bosutinib, ZM.306416, nilotinib",0.239577516576788,0.0501222959631252,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.5632,1.5,0.0845,58,0.525,"xanomeline",1.07314329105031,0.279840696594043,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.38766,-0.949,0.526,1001,0.893,"darifenacin, iododexetimide, diphemanil",0.279014255846261,0.0491485411114536,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",-0.32628,-0.801,0.704,1217,0.889,"sulmazole, istradefylline",0.152427340857888,0.0510982390297863,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.38321,-0.941,0.527,1040,0.877,"methyldopa, xylazine, isoxsuprine, oxymetazoline, epinephrine, isoetharine",0.278189384787453,0.0570004066339595,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.37604,1.01,0.425,189,0.881,"atenolol......, dihydroergocristine, idazoxan, naftidrofuryl",0.371611069949688,0.0550240915879521,FALSE
+"H1650","Pearson.est","AKT inhibitor",-0.34247,-0.844,0.667,908,0.892,"MK.2206, triciribine, GSK2110183, palomid.529, AZD5363, CCT128930, AT7867",0.175874166083451,0.0496351456238769,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.23664,0.644,0.891,326,0.934,"DMH1, SB.505124, brigatinib, CEP.37440, crizotinib",0.0501222959631252,0.0296531237699066,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.26332,-0.662,0.865,1261,0.989,"RU.58841",0.0629838925351858,0.0048037084028206,FALSE
+"H1650","Pearson.est","antioxidant",-0.40221,-0.977,0.489,1063,0.868,"benfotiamine, mesna, rutin",0.31069114087638,0.0614802748235081,FALSE
+"H1650","Pearson.est","AP inhibitor",-0.63364,-1.58,0.0425,1330,0.458,"embelin, tanshinone.i, GDC.0152",1.37161106994969,0.339134521996131,FALSE
+"H1650","Pearson.est","ATPase inhibitor",0.6778,1.85,0.0213,31,0.328,"k.strophanthidin, evodiamine, NMS.873, digoxin",1.67162039656126,0.484126156288321,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.31919,0.848,0.595,395,0.832,"CCT137690, CCT129202, PHA.680632, danusertib, barasertib.HQPA, aurora.a.inhibitor.i, AMG900, barasertib, KW.2449, SNS.314, PF.03814735",0.22548303427145,0.0798766737092761,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26042,0.687,0.83,1073,0.936,"josamycin, azalomycin.b, azithromycin, valnemulin, dirithromycin, tilmicosin, tedizolid, radezolid",0.0809219076239261,0.0287241512618947,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.26726,-0.658,0.879,881,0.97,"sarafloxacin, trovafloxacin, novobiocin, finafloxacin",0.0560111249262281,0.0132282657337552,FALSE
+"H1650","Pearson.est","BCL inhibitor",0.51987,1.41,0.0912,337,0.481,"venetoclax, gossypol, TW.37, oridonin",1.04000516167158,0.317854923626168,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.31711,0.874,0.61,992,0.922,"GZD824, ponatinib, imatinib, bafetinib, tozasertib, dasatinib, metatinib, flumatinib, bosutinib, nilotinib",0.214670164989233,0.0352690789463706,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",-0.18794,-0.463,0.99,1041,0.988,"zaleplon, CGS.20625, lorazepam",0.00436480540245009,0.00524305541237188,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.43823,1.17,0.256,167,0.801,"I.BET.762, PFI.1",0.59176003468815,0.0963674839157623,FALSE
+"H1650","Pearson.est","calcium channel blocker",0.26762,0.722,0.78,136,0.982,"carboxyamidotriazole, SKF.96365",0.10790539730952,0.00788851221305034,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",-0.43071,-1.06,0.385,1203,0.909,"MK.0812, RS.504393, navarixin",0.414539270491499,0.0414361167780325,FALSE
+"H1650","Pearson.est","CDK inhibitor",0.45584,1.2,0.252,276,0.798,"PHA.848125, dinaciclib, indisulam, abemaciclib, AT.7519, BMS.387032, JNJ.7706621, alvocidib",0.598599459218456,0.0979971086492706,FALSE
+"H1650","Pearson.est","CHK inhibitor",-0.41457,-1.04,0.409,939,0.834,"LY2606368, CHIR.124, SCH.900776, AZD7762",0.388276691992658,0.0788339493622613,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",-0.41549,-1.06,0.408,912,0.909,"AM.404, suxibuzone, meloxicam, ketoprofen, piroxicam, amfenac, acetylsalicylsalicylic.acid, curcumin, tryptanthrin, indoprofen, FR.122047, pterostilbene, metoxibutropate, naproxen",0.38933983691012,0.0414361167780325,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",-0.43393,-1.1,0.336,1243,0.957,"cobicistat, itraconazole",0.473660722610156,0.0190880622231565,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.34742,0.956,0.483,223,0.913,"carmustine, estramustine, satraplatin, mitomycin.c",0.316052869248488,0.039529222465701,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.32268,0.887,0.593,359,0.934,"carmustine, mechlorethamine, sangivamycin, chlorambucil, bendamustine, pibenzimol, teroxirone, carboplatin",0.226945306635737,0.0296531237699066,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",-0.36309,-0.92,0.562,1245,0.888,"RG108, azacitidine",0.250263684430939,0.051587034221399,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",-0.48076,-1.22,0.241,1163,0.794,"adefovir.dipivoxil, cephalomannine, cidofovir",0.617982957425132,0.100179497572904,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",-0.3177,-0.801,0.71,1375,0.889,"estramustine.phosphate, CB.10.277",0.148741651280925,0.0510982390297863,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",-0.54953,-1.37,0.143,993,0.578,"UH.232...., clebopride, domperidone, ziprasidone, amisulpride, raclopride, mesoridazine, acetophenazine, nemonapride, oxiperomide, remoxipride",0.844663962534938,0.238072161579471,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",-0.22929,-0.571,0.946,885,1,"ethinyl.estradiol, estrone, estradiol, PPT",0.0241088635982073,0,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",-0.47148,-1.18,0.248,1141,0.846,"raloxifene, fulvestrant",0.605548319173784,0.0726296369609765,FALSE
+"H1650","Pearson.est","FGFR inhibitor",0.56166,1.54,0.0829,100,0.537,"dovitinib, nintedanib, regorafenib, erdafitinib, lenvatinib",1.08144546944973,0.270025714300444,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.28322,0.744,0.738,419,0.981,"dovitinib, tyrphostin.AG.1296, sorafenib, TG.101348, KW.2449, ponatinib, gilteritinib",0.131943638176958,0.0083309926200515,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",-0.28658,-0.724,0.793,1003,0.957,"triamcinolone, piretanide, clobetasol.propionate, triamcinolone.acetonide, rimexolone, difluprednate, flumethasone.pivalate, dexamethasone.acetate, fludroxycortide, prednisolone.acetate",0.100726812682396,0.0190880622231565,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",-0.35394,-0.877,0.61,1084,0.885,"CPP, ACDPP, MTPG, latrepirdine, SIB.1757",0.214670164989233,0.0530567293021746,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.53927,-1.32,0.181,1312,0.65,"kenpaullone, LY2090314",0.742321425130815,0.187086643357144,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.68522,1.8,0.0225,196,0.294,"PHA.848125, GSK1838705A, danusertib",1.64781748188864,0.531652669587843,FALSE
+"H1650","Pearson.est","HCV inhibitor",-0.75819,-1.9,0.0116,1257,0.103,"Ro.9187, PSI.7976, narlaprevir, embelin",1.93554201077308,0.987162775294828,TRUE
+"H1650","Pearson.est","HDAC inhibitor",-0.51695,-1.29,0.193,1160,0.675,"SB.939, nexturastat.a, mocetinostat, ACY.1215, tacedinaline, RGFP966, romidepsin, entinostat, JNJ.26481585, RG2833",0.714442690992226,0.170696227168975,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",-0.57126,-1.41,0.107,1105,0.538,"levocetirizine, ranitidine, cimetidine, famotidine, BF2.649, tiotidine, lafutidine, ICI.162846, tecastemizole, chloropyramine",0.97061622231479,0.269217724333611,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.81207,-2.04,0,1171,0.0314,"lovastatin, mevastatin, atorvastatin, fluvastatin, pitavastatin, simvastatin",Inf,1.50307035192679,TRUE
+"H1650","Pearson.est","HSP inhibitor",-0.39689,-1,0.442,804,0.886,"alvespimycin, SNX.2112, PU.H71, BIIB021, NVP.AUY922, XL888, KW.2478, VER.49009, guanidine",0.354577730650908,0.0525662781129492,FALSE
+"H1650","Pearson.est","JAK inhibitor",-0.3407,-0.85,0.647,1128,0.908,"LY2784544, PRT062070, pacritinib, atiprimod",0.1890957193313,0.0419141514789149,FALSE
+"H1650","Pearson.est","KIT inhibitor",-0.31773,-0.788,0.715,1333,0.886,"vatalanib, midostaurin, telatinib",0.145693958198919,0.0525662781129492,FALSE
+"H1650","Pearson.est","MDM inhibitor",-0.65951,-1.66,0.0323,1317,0.349,"CGM097, RITA",1.4907974776689,0.45717457304082,FALSE
+"H1650","Pearson.est","MEK inhibitor",-0.58635,-1.45,0.0864,1026,0.559,"refametinib, PD.0325901, PD.198306, BIX.02188, MEK162, U.0126, PD.318088, Ro.4987655, AZD8330, PD.184352, TAK.733",1.06348625752111,0.252588192113577,FALSE
+"H1650","Pearson.est","MET inhibitor",-0.29779,-0.723,0.807,1179,0.935,"PF.04217903",0.0931264652779296,0.0291883891274822,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.39967,1.08,0.359,207,0.895,"D.64131, vinblastine, vinflunine, cytochalasin.b",0.444905551421681,0.048176964684088,FALSE
+"H1650","Pearson.est","mTOR inhibitor",-0.22222,-0.56,0.95,1264,0.989,"deforolimus, torin.2, PF.05212384, sirolimus",0.0222763947111523,0.0048037084028206,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",-0.43579,-1.05,0.382,1144,0.849,"Ro.106.9920, bortezomib, curcumin, parthenolide...., BAY.11.7085",0.417936637088291,0.0710923097560473,FALSE
+"H1650","Pearson.est","opioid receptor agonist",-0.35756,-0.881,0.592,1295,0.936,"ADL5859",0.22767829327708,0.0287241512618947,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.34647,0.923,0.514,5,0.896,"talmapimod",0.289036881004724,0.0476919903378748,FALSE
+"H1650","Pearson.est","PARP inhibitor",-0.3212,-0.806,0.699,1227,0.931,"AZD2461, E7449",0.155522824254319,0.0310503190186574,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3191,0.855,0.608,117,0.884,"dovitinib, nintedanib, regorafenib, lenvatinib, pazopanib",0.216096420727265,0.0535477349869269,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",0.32165,0.853,0.604,318,0.854,"sodium.stibogluconate, GSK2830371, AS.1949490, mycophenolic.acid, CID.5458317",0.218963061378868,0.068542129310995,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",-0.42356,-1.05,0.393,1369,0.849,"GSK256066, papaverine",0.405607449624573,0.0710923097560473,FALSE
+"H1650","Pearson.est","PI3K inhibitor",0.21643,0.58,0.925,78,0.94,"idelalisib, buparlisib, alpelisib",0.0338582672609674,0.0268721464003014,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.77241,2.1,0.00279,261,0.108,"volasertib, NMS.1286937, GW.843682X, BI.2536, HMN.214, rigosertib",2.5543957967264,0.96657624451305,TRUE
+"H1650","Pearson.est","potassium channel blocker",-0.59317,-1.52,0.0595,1114,0.536,"mepivacaine, oleoylethanolamide, meglitinide",1.22548303427145,0.27083521030723,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",-0.73323,-1.85,0.0111,1188,0.112,"fenofibrate, S26948, oleoylethanolamide, GW.501516, pterostilbene",1.95467702121334,0.950781977329818,TRUE
+"H1650","Pearson.est","progesterone receptor agonist",-0.22562,-0.559,0.946,1125,0.968,"melengestrol.acetate, norgestrel",0.0241088635982073,0.0141246426916063,FALSE
+"H1650","Pearson.est","proteasome inhibitor",-0.58154,-1.46,0.0997,956,0.613,"carfilzomib, delanzomib, ixazomib, bortezomib, oprozomib, ixazomib.citrate, ONX.0914",1.00130484168834,0.212539525481585,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.54499,1.47,0.0885,320,0.437,"clofoctol, harringtonine, homoharringtonine, tedizolid.phosphate, anguidine, bruceantin, thiostrepton, puromycin, chloramphenicol.palmitate",1.05305672930217,0.359518563029578,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.4011,1.06,0.4,265,0.825,"PP.121, mubritinib, CP.724714, tyrphostin.A9",0.397940008672038,0.0835460514500749,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.39571,1.07,0.357,52,0.858,"SB.590885, regorafenib",0.447331783887807,0.0665127121512946,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.39502,-0.999,0.459,1294,0.853,"apatinib, vandetanib",0.338187314462739,0.069050968832477,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.61039,1.7,0.0397,286,0.356,"adarotene, fenretinide, adapalene, tamibarotene",1.40120949323689,0.448550002027125,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.36092,0.97,0.478,342,0.927,"pentostatin, cytarabine, hydroxyurea, cladribine",0.320572103387881,0.0329202658555029,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",0.41019,1.09,0.346,98,0.936,"zolmitriptan, pardoprunox",0.460923901207223,0.0287241512618947,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",0.24963,0.661,0.869,65,0.942,"SB.200646, pirenperone",0.0609802235513335,0.0259490972071227,FALSE
+"H1650","Pearson.est","sodium channel blocker",-0.35429,-0.878,0.586,1114,0.912,"mepivacaine, mexiletine, A.803467, quinidine",0.232102383981909,0.0400051616715838,FALSE
+"H1650","Pearson.est","src inhibitor",0.26129,0.693,0.779,1072,0.958,"masitinib, KX2.391, saracatinib, TG.100572, dasatinib, PP.1, bosutinib, ZM.306416, PP.2",0.108462542327436,0.0186344909214556,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",0.26418,0.716,0.824,348,0.957,"chlormidazole, sulconazole, posaconazole",0.0840727883028842,0.0190880622231565,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.451,-1.11,0.339,739,0.988,"LY2109761, SB.525334, repsox, SB.431542, D.4476",0.469800301796918,0.00524305541237188,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.50597,1.36,0.14,563,0.515,"ftorafur, carmofur, raltitrexed, doxifluridine, capecitabine",0.853871964321762,0.288192770958809,FALSE
+"H1650","Pearson.est","topoisomerase inhibitor",-0.22785,-0.567,0.945,1039,1,"licochalcone.a, idarubicin, TAS.103, rubitecan, fleroxacin, teniposide, voreloxin, beta.lapachone, etoposide, camptothecin",0.0245681914907371,0,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.56765,1.48,0.101,388,0.482,"vindesine, oxibendazole, fenbendazole, vinblastine, docetaxel, paclitaxel, verubulin, vinorelbine, ABT.751, fosbretabulin, BNC105, taltobulin, nocodazole, vincristine, dolastatin.10, epothilone.b, KX2.391, parbendazole",0.995678626217357,0.31695296176115,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.34914,0.945,0.495,62,0.891,"PP.121, tivantinib, regorafenib, mubritinib",0.305394801066431,0.0501222959631252,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.2377,0.632,0.891,117,0.919,"dovitinib, nintedanib, regorafenib, SAR131675, lenvatinib, pazopanib",0.0501222959631252,0.0366844886138887,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.57285,-1.42,0.115,1006,0.574,"maxacalcitol, tacalcitol, calcitriol, paricalcitol, ercalcitriol",0.939302159646388,0.241088107602027,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.38057,0.946,0.499,454,0.89,"neratinib, tucatinib, AEE788, CP.724714, lapatinib, GW.583340, dacomitinib, PD.153035, OSI.420, dovitinib, CUDC.101, afatinib, osimertinib, BMS.599626, TAK.285, canertinib, FERb.033, AZD8931",0.30189945437661,0.0506099933550872,FALSE
+"H1975","Pearson.est","Abl kinase inhibitor",-0.72949,-1.96,0.00512,1349,0.0621,"flumatinib, GZD824, KW.2449, ponatinib, dasatinib",2.29073003902417,1.20690839982342,TRUE
+"H1975","Pearson.est","acetylcholine receptor agonist",0.37242,0.937,0.527,301,0.88,"pilocarpine, tremorine, oxiracetam",0.278189384787453,0.0555173278498314,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",0.69158,1.74,0.0169,333,0.216,"diphemanil, hyoscyamine, darifenacin, dicycloverine",1.77211329538633,0.665546248849069,TRUE
+"H1975","Pearson.est","adenosine receptor antagonist",0.28586,0.715,0.794,270,0.922,"CGS.15943, PSB.1115",0.100179497572904,0.0352690789463706,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",0.34629,0.879,0.596,68,0.868,"lidamidine, methyldopa",0.224753740259764,0.0614802748235081,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.37463,0.946,0.516,321,0.89,"RS.17053, prazosin, idazoxan, vincamine, carvedilol, levobunolol",0.287350298372789,0.0506099933550872,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.29526,0.744,0.775,166,0.901,"uprosertib, A.674563, triciribine",0.11069829749369,0.045275209020937,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.17783,-0.485,0.981,1098,0.984,"alectinib, brigatinib, lorlatinib, AP26113",0.0083309926200515,0.00700490156865849,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",0.57701,1.44,0.123,330,0.515,"cyproterone.acetate, enzalutamide, flutamide",0.910094888560602,0.288192770958809,FALSE
+"H1975","Pearson.est","antioxidant",-0.76375,-2.05,0.00763,1378,0.112,"trolox, mesna, benfotiamine",2.11747546204512,0.950781977329818,TRUE
+"H1975","Pearson.est","AP inhibitor",0.30287,0.778,0.722,387,0.888,"LCL.161, tanshinone.i",0.141462802430361,0.051587034221399,FALSE
+"H1975","Pearson.est","ATPase inhibitor",-0.21223,-0.557,0.931,994,0.988,"rabeprazole, blebbistatin...., ouabain, k.strophanthidin, oligomycin.a",0.0310503190186574,0.00524305541237188,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",-0.58866,-1.59,0.0547,1229,0.305,"hesperadin, MK.8745, AMG900, barasertib, barasertib.HQPA, alisertib, KW.2449, SNS.314, GSK1070916, CYC116, AT.9283",1.26201267366657,0.515700160653214,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.52928,1.33,0.164,186,0.674,"azithromycin, azalomycin.b, dirithromycin",0.785156151952302,0.17134010346468,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.50608,-1.37,0.127,1376,0.377,"novobiocin, finafloxacin",0.896196279044043,0.423658649794207,FALSE
+"H1975","Pearson.est","BCL inhibitor",-0.27361,-0.711,0.78,394,1,"obatoclax, HA14.1, oridonin, navitoclax, ABT.737, venetoclax, TW.37, gossypol",0.10790539730952,0,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.72181,-1.98,0.00964,1349,0.0711,"flumatinib, GZD824, ponatinib, dasatinib",2.01592296609717,1.14813039927023,TRUE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.16954,0.42,0.998,206,0.995,"indiplon, zaleplon",0.000869458712628891,0.00217691925427455,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",0.35113,0.857,0.596,110,0.84,"JQ1....",0.224753740259764,0.0757207139381184,FALSE
+"H1975","Pearson.est","calcium channel blocker",0.49553,1.24,0.225,359,0.711,"tetrandrine, fendiline, SKF.96365, cinnarazine",0.647817481888638,0.148130399270234,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",0.50613,1.3,0.187,529,0.612,"PF.04136309, navarixin, RS.504393, ZK811752, MK.0812, SB.225002",0.728158393463501,0.213248577854439,FALSE
+"H1975","Pearson.est","CDK inhibitor",0.39333,0.996,0.461,382,0.939,"BMS.387032, arcyriaflavin.a, JNJ.7706621, PHA.793887, AZD5438, dinaciclib, kenpaullone, CR8..R., BMS.265246, alvocidib",0.336299074610352,0.0273344077338891,FALSE
+"H1975","Pearson.est","CHK inhibitor",0.66618,1.71,0.0312,105,0.218,"PF.477736, SB.218078, CHIR.124",1.50584540598156,0.661543506395395,TRUE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.25851,-0.67,0.831,1289,1,"sulfasalazine, ketoprofen, tepoxalin, metoxibutropate",0.080398976215889,0,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.5981,-1.58,0.0773,1206,0.273,"cobicistat, eplerenone, itraconazole",1.11182050608168,0.563837352959244,FALSE
+"H1975","Pearson.est","DNA alkylating agent",0.43343,1.1,0.337,223,0.769,"dacarbazine, mitomycin.c, melphalan, ifosfamide, estramustine",0.472370099128661,0.114073660198569,FALSE
+"H1975","Pearson.est","DNA inhibitor",0.3239,0.836,0.654,322,0.814,"melphalan, busulfan, metronidazole, primaquine, bendamustine",0.184422251675733,0.0893755951107988,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.6647,1.65,0.0351,184,0.272,"SGI.1027, azacitidine, fdcyd, disulfiram",1.45469288353418,0.565431095965801,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",0.23236,0.583,0.939,160,0.987,"trifluridine",0.0273344077338891,0.00568284733036327,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",0.33846,0.857,0.614,531,0.84,"mitomycin.c, enocitabine, floxuridine, capecitabine, nelarabine, cyclocytidine, anisomycin",0.211831628858832,0.0757207139381184,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",0.25591,0.659,0.881,29,0.953,"sertindole, piperacetazine",0.0550240915879521,0.0209070993616736,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.42284,-1.16,0.25,1089,0.613,"ethinyl.estradiol, estradiol, PPT, estrone",0.602059991327962,0.212539525481585,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",0.65091,1.64,0.0248,312,0.252,"danazol, raloxifene, toremifene, clomifene",1.60554831917378,0.598599459218456,FALSE
+"H1975","Pearson.est","FGFR inhibitor",0.51648,1.31,0.165,139,0.674,"regorafenib, lucitanib, lenvatinib",0.782516055786094,0.17134010346468,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",-0.28322,-0.766,0.729,1369,0.965,"KW.2449, ponatinib, midostaurin",0.137272471682025,0.0154726866562074,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",-0.47209,-1.25,0.219,1177,0.508,"fluocinolone.acetonide, hydrocortisone, prednisolone.acetate, dexamethasone.acetate, desonide, prednisolone, beclomethasone.dipropionate, prednisolone.hemisuccinate, fluticasone.propionate, piretanide, triamcinolone",0.659555885159882,0.294136287716081,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",0.41307,1.05,0.378,310,0.851,"CGP.37849, IEM1754, diazooxonorleucine, MTPG, CPP, ACDPP",0.422508200162775,0.0700704399154121,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",0.24891,0.617,0.909,49,0.978,"AZD2858",0.0414361167780325,0.00966114521239857,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",0.39212,0.989,0.453,32,0.921,"GW.441756",0.343901797987168,0.0357403698031511,FALSE
+"H1975","Pearson.est","HCV inhibitor",0.7096,1.76,0.017,98,0.235,"PSI.7976, daclatasvir",1.76955107862173,0.628932137728264,TRUE
+"H1975","Pearson.est","HDAC inhibitor",-0.23229,-0.612,0.92,1419,0.978,"RG2833, mocetinostat",0.0362121726544447,0.00966114521239857,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",0.3871,0.966,0.497,218,0.938,"zolantidine, cyproheptadine, tecastemizole, astemizole, chloropyramine, nizatidine",0.303643611266668,0.0277971616209356,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.74732,-1.98,0.0068,1216,0.0711,"lovastatin, atorvastatin, simvastatin, fluvastatin, pitavastatin",2.16749108729376,1.14813039927023,TRUE
+"H1975","Pearson.est","HSP inhibitor",0.22138,0.569,0.952,345,0.978,"NMS.E973, SNX.2112, XL888",0.0213630516155257,0.00966114521239857,FALSE
+"H1975","Pearson.est","JAK inhibitor",0.36894,0.927,0.561,217,0.874,"LY2784544, pacritinib, baricitinib, TG.101348, CEP.33779, AZD1480",0.251037138743839,0.058488567365597,FALSE
+"H1975","Pearson.est","KIT inhibitor",-0.35427,-0.952,0.473,1413,0.832,"midostaurin, dasatinib, KI.8751",0.325138859262188,0.0798766737092761,FALSE
+"H1975","Pearson.est","MDM inhibitor",-0.52533,-1.43,0.117,1162,0.335,"idasanutlin, AMG.232, serdemetan, RITA",0.931814138253838,0.474955192963155,FALSE
+"H1975","Pearson.est","MEK inhibitor",-0.69387,-1.9,0.0211,1150,0.0777,"U.0126, MEK162, PD.198306, PD.98059, AS.703026, cobimetinib, trametinib, Ro.4987655, TAK.733, selumetinib, PD.318088, AZD8330, refametinib, PD.184352",1.67571754470231,1.10957898119909,TRUE
+"H1975","Pearson.est","MET inhibitor",0.27174,0.677,0.84,326,0.951,"AMG458, INC.280",0.0757207139381184,0.0218194830625861,FALSE
+"H1975","Pearson.est","microtubule inhibitor",0.44102,1.11,0.329,475,0.816,"colchicine, D.64131, podophyllotoxin, triclabendazole, vinflunine, cabazitaxel",0.482804102050026,0.0883098412461389,FALSE
+"H1975","Pearson.est","mTOR inhibitor",-0.53595,-1.44,0.105,1082,0.405,"ku.0063794, AZD2014, GSK2126458, GDC.0980, deforolimus, WYE.354, OSI.027, PKI.179, everolimus, MLN0128, LY3023414, temsirolimus, torin.1, NVP.BEZ235, PF.04691502, SB.2343",0.978810700930062,0.392544976785331,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",-0.29111,-0.774,0.692,1218,0.997,"EVP4593, BAY.11.7085, BAY.11.7082",0.159893905543242,0.00130484168834428,FALSE
+"H1975","Pearson.est","opioid receptor agonist",0.38996,0.957,0.483,21,0.926,"salvinorin.a",0.316052869248488,0.0333890133180656,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",0.51409,1.3,0.173,357,0.612,"talmapimod, SB.242235, SB.239063, TAK.715",0.761953896871205,0.213248577854439,FALSE
+"H1975","Pearson.est","PARP inhibitor",0.44778,1.1,0.351,22,0.769,"PJ.34",0.454692883534176,0.114073660198569,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.3734,-1.02,0.391,1299,0.739,"linifanib, SU014813, axitinib, ponatinib, dasatinib, KI.8751",0.407823242604133,0.131355561605174,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",0.29643,0.75,0.754,261,0.912,"AS.1949490, mycophenolic.acid",0.122628654130226,0.0400051616715838,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",0.35024,0.864,0.636,360,0.871,"cilostamide, YM.976, enoximone",0.196542884351586,0.0599818449923368,FALSE
+"H1975","Pearson.est","PI3K inhibitor",-0.41706,-1.09,0.345,1099,0.651,"PI.828, BGT226, GSK2126458, GDC.0980, PI3K.IN.2, PKI.179, LY3023414, ZSTK.474, GDC.0941, buparlisib, NVP.BEZ235, PF.04691502, SB.2343",0.462180904926726,0.186419011431808,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.68434,1.79,0.0198,324,0.737,"BI.2536, NMS.1286937, GSK461364, GW.843682X, volasertib",1.70333480973847,0.132532512140949,FALSE
+"H1975","Pearson.est","potassium channel blocker",0.47016,1.18,0.272,266,0.815,"dofetilide, oleoylethanolamide, ML133",0.565431095965801,0.0888423912600234,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",-0.3077,-0.844,0.612,1371,1,"fenofibrate",0.213248577854439,0,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.41986,-1.13,0.314,1199,0.623,"norgestrel, norethindrone, tanaproget",0.503070351926785,0.20551195334083,FALSE
+"H1975","Pearson.est","proteasome inhibitor",0.45128,1.16,0.3,576,0.818,"MG.132, ixazomib, delanzomib, carfilzomib, bortezomib",0.522878745280338,0.087246696328677,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.45415,1.13,0.335,433,0.808,"bruceantin, homoharringtonine, harringtonine, puromycin, chloramphenicol.palmitate, clofoctol, thiostrepton, emetine, tedizolid.phosphate, anguidine",0.474955192963155,0.0925886392254138,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.3357,0.842,0.644,435,0.844,"CP.724714, tyrphostin.A9, AV.412, BMS.599626, rheochrysidin",0.191114132640188,0.073657553374345,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.57967,1.48,0.0923,446,0.471,"regorafenib, CEP.32496, SB.590885, AZ.628, GDC.0879, vemurafenib, LGX818, RAF265, dabrafenib",1.03479829897409,0.326979092871104,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.35314,0.897,0.571,262,0.882,"regorafenib, apatinib",0.243363891754152,0.0545314148681803,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.61628,1.52,0.0563,193,0.43,"adarotene, AM.580, tamibarotene, CD.437",1.24949160514865,0.366531544420413,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.22685,0.568,0.947,480,0.96,"fludarabine.phosphate, gemcitabine, fludarabine",0.0236500209967266,0.0177287669604316,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.52871,-1.43,0.13,1447,0.335,"aripiprazole",0.886056647693163,0.474955192963155,FALSE
+"H1975","Pearson.est","serotonin receptor antagonist",-0.29287,-0.777,0.71,1447,1,"aripiprazole",0.148741651280925,0,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.24513,-0.656,0.868,913,1,"quinidine, cibenzoline, butamben, benzocaine, A.803467, oxcarbazepine, benzethonium, mexiletine, mepivacaine",0.0614802748235081,0,FALSE
+"H1975","Pearson.est","src inhibitor",0.34355,0.883,0.566,268,0.885,"KX2.391, TG.100572, saracatinib",0.247183568811729,0.0530567293021746,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",0.35615,0.914,0.543,403,0.874,"ketoconazole, lanoconazole, posaconazole",0.265200170411153,0.058488567365597,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.71786,1.78,0.0168,127,0.398,"LY2109761, repsox, SB.525334",1.77469071827414,0.400116927926312,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.69834,1.77,0.0151,441,0.292,"ftorafur, doxifluridine, trifluridine, raltitrexed, carmofur, capecitabine",1.82102305270683,0.534617148551582,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",0.33144,0.836,0.643,282,0.814,"dexrazoxane, SN.38, exatecan.mesylate, genz.644282, topotecan, camptothecin, nemorubicin",0.191789027075778,0.0893755951107988,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",0.5305,1.37,0.141,567,0.629,"vinorelbine, vincristine, KX2.391, combretastatin.A.4, CYT.997, taltobulin, podophyllotoxin, plinabulin, dolastatin.10, indibulin, oxibendazole, albendazole, ABT.751, epothilone.d, vindesine, flubendazole, nocodazole, mebendazole",0.85078088734462,0.201349354554731,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",-0.29572,-0.794,0.682,1345,1,"cabozantinib, aminopurvalanol.a, UNC2250, dasatinib, NVP.TAE226",0.166215625343521,0,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",-0.24199,-0.649,0.892,1299,0.976,"linifanib, semaxanib, SU014813, SAR131675, cabozantinib, axitinib, KI.8751",0.0496351456238769,0.0105501823333082,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.44857,1.14,0.29,48,0.822,"maxacalcitol",0.537602002101044,0.0851281824599496,FALSE
+"H2009","Pearson.est","EGFR inhibitor",-0.37127,-0.92,0.587,993,0.879,"vandetanib, tyrphostin.AG.494, rociletinib, OSI.420, AEE788, osimertinib, TAK.285, pelitinib, WZ8040, canertinib, PD.153035, afatinib, erlotinib, gefitinib, icotinib, BIBX.1382, tyrphostin.AG.1478, BIBU.1361",0.231361898752386,0.0560111249262281,FALSE
+"H2009","Pearson.est","Abl kinase inhibitor",-0.16481,-0.404,0.993,1174,0.997,"bafetinib, bosutinib",0.00305075150461883,0.00130484168834428,FALSE
+"H2009","Pearson.est","acetylcholine receptor agonist",-0.26812,-0.661,0.863,1325,1,"tremorine",0.0639892042847904,0,FALSE
+"H2009","Pearson.est","acetylcholine receptor antagonist",-0.48225,-1.2,0.256,1245,0.853,"dicycloverine, diphemanil",0.59176003468815,0.069050968832477,FALSE
+"H2009","Pearson.est","adenosine receptor antagonist",-0.45512,-1.12,0.331,1068,0.846,"SCH.58261, sulmazole, CGS.15943",0.480172006224281,0.0726296369609765,FALSE
+"H2009","Pearson.est","adrenergic receptor agonist",-0.27803,-0.684,0.837,714,1,"terbutaline, xylazine, A61603, norepinephrine, oxymetazoline, clenbuterol, metaraminol, isoxsuprine, buphenine, epinephrine",0.07727454200674,0,FALSE
+"H2009","Pearson.est","adrenergic receptor antagonist",-0.31521,-0.762,0.771,1217,0.969,"carvedilol, pindolol, levobunolol, propranolol, vincamine",0.112945621949043,0.0136762229492347,FALSE
+"H2009","Pearson.est","AKT inhibitor",-0.36963,-0.915,0.57,1060,0.867,"CCT128930, ONC201, uprosertib, triciribine, palomid.529",0.244125144327509,0.0619809025237897,FALSE
+"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4418,-1.05,0.394,713,0.899,"CEP.37440, DMH1, alectinib, crizotinib, NVP.TAE684, lorlatinib, AZD3463, GW.788388",0.404503778174426,0.0462403082667712,FALSE
+"H2009","Pearson.est","androgen receptor antagonist",-0.39053,-0.957,0.51,911,0.848,"cyproterone.acetate, flutamide, nilutamide, bicalutamide",0.292429823902064,0.0716041477432862,FALSE
+"H2009","Pearson.est","antioxidant",0.40334,1.12,0.304,15,0.902,"trolox",0.517126416391246,0.0447934624580583,FALSE
+"H2009","Pearson.est","AP inhibitor",0.27871,0.781,0.725,34,0.836,"idronoxil",0.139661993429006,0.0777937225609836,FALSE
+"H2009","Pearson.est","ATPase inhibitor",0.71293,2.05,0.0121,212,0.181,"k.strophanthidin, oligomycin.a, evodiamine, omeprazole, NMS.873, digoxin",1.91721462968355,0.742321425130815,TRUE
+"H2009","Pearson.est","Aurora kinase inhibitor",-0.2359,-0.574,0.939,869,1,"MK.8745, KW.2449, tozasertib, ZM.447439, GSK1070916, hesperadin, MK.5108, PF.03814735, MLN.8054",0.0273344077338891,0,FALSE
+"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36617,-0.891,0.603,815,0.797,"dirithromycin, tedizolid, azalomycin.b, azithromycin",0.219682687859849,0.0985416786038876,FALSE
+"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.3696,-0.894,0.601,1237,0.809,"trovafloxacin, novobiocin",0.22112552799726,0.0920514783877277,FALSE
+"H2009","Pearson.est","BCL inhibitor",0.33323,0.952,0.471,356,1,"ABT.737, gossypol, TW.37, venetoclax, obatoclax",0.326979092871104,0,FALSE
+"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.22682,-0.551,0.942,1174,1,"bafetinib, bosutinib",0.0259490972071227,0,FALSE
+"H2009","Pearson.est","benzodiazepine receptor agonist",-0.22798,-0.557,0.951,987,1,"CGS.20625, ZK.93423, indiplon, zaleplon",0.0218194830625861,0,FALSE
+"H2009","Pearson.est","bromodomain inhibitor",-0.25327,-0.625,0.895,1252,1,"JQ1....",0.048176964684088,0,FALSE
+"H2009","Pearson.est","calcium channel blocker",0.31395,0.898,0.507,106,0.834,"efonidipine.monoethanolate, carboxyamidotriazole",0.294992040666664,0.0788339493622613,FALSE
+"H2009","Pearson.est","CC chemokine receptor antagonist",-0.42633,-1.05,0.416,1132,0.899,"MK.0812, PF.04136309, navarixin",0.380906669373257,0.0462403082667712,FALSE
+"H2009","Pearson.est","CDK inhibitor",-0.40046,-0.978,0.478,1153,0.924,"JNJ.7706621, arcyriaflavin.a, BMS.387032, kenpaullone, PHA.793887, AZD5438, alvocidib",0.320572103387881,0.0343280287798933,FALSE
+"H2009","Pearson.est","CHK inhibitor",-0.52406,-1.26,0.197,965,1,"SB.218078, SCH.900776, LY2606368, LY2603618",0.705533773838407,0,FALSE
+"H2009","Pearson.est","cyclooxygenase inhibitor",-0.4912,-1.2,0.256,1154,0.853,"meloxicam, FR.122047, amfenac, indoprofen, curcumin, ramifenazone, aspirin, FK.3311",0.59176003468815,0.069050968832477,FALSE
+"H2009","Pearson.est","cytochrome P450 inhibitor",-0.46809,-1.15,0.306,1085,0.875,"cobicistat, clotrimazole, PF.4981517",0.51427857351842,0.0579919469776868,FALSE
+"H2009","Pearson.est","DNA alkylating agent",-0.51487,-1.25,0.191,929,0.977,"ifosfamide, mitomycin.c, satraplatin, TH.302, carboplatin, cyclophosphamide, streptozotocin, melphalan, dacarbazine",0.718966632752272,0.0101054362812269,FALSE
+"H2009","Pearson.est","DNA inhibitor",-0.41378,-1.02,0.426,915,0.881,"nimorazole, primaquine, valrubicin, carboplatin, busulfan, tirapazamine, sangivamycin, bendamustine, nithiamide, melphalan",0.370590400897281,0.0550240915879521,FALSE
+"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.70589,-1.72,0.00657,1098,0.288,"fdcyd, SGI.1027, decitabine, azacitidine",2.18243463044022,0.540607512240769,FALSE
+"H2009","Pearson.est","DNA polymerase inhibitor",0.30707,0.853,0.622,222,0.813,"menadione, cidofovir, adefovir.dipivoxil",0.206209615309181,0.0899094544059319,FALSE
+"H2009","Pearson.est","DNA synthesis inhibitor",-0.47395,-1.13,0.314,848,0.893,"enocitabine, nelarabine, mitomycin.c, estramustine.phosphate, cyclocytidine, CB.10.277, anisomycin, floxuridine, altretamine",0.503070351926785,0.0491485411114536,FALSE
+"H2009","Pearson.est","dopamine receptor antagonist",-0.37011,-0.896,0.604,970,0.824,"oxiperomide, acetophenazine, amisulpride, sertindole, ziprasidone, piperacetazine, isofloxythepin",0.218963061378868,0.0840727883028842,FALSE
+"H2009","Pearson.est","estrogen receptor agonist",-0.30786,-0.749,0.804,1075,0.968,"PPT, estradiol.cypionate, ethinyl.estradiol",0.0947439512515487,0.0141246426916063,FALSE
+"H2009","Pearson.est","estrogen receptor antagonist",-0.36732,-0.896,0.589,945,0.824,"fulvestrant, clomifene, raloxifene, toremifene",0.229884705212898,0.0840727883028842,FALSE
+"H2009","Pearson.est","FGFR inhibitor",0.44323,1.32,0.147,306,0.665,"erdafitinib, lenvatinib, dovitinib, PD.173074, nintedanib",0.832682665251824,0.177178354696895,FALSE
+"H2009","Pearson.est","FLT3 inhibitor",0.3675,1.02,0.412,166,0.936,"ponatinib, TG.101348, sorafenib, GTP.14564, dovitinib, ENMD.2076",0.385102783966865,0.0287241512618947,FALSE
+"H2009","Pearson.est","glucocorticoid receptor agonist",0.59498,1.72,0.0338,232,0.254,"dexamethasone.acetate, triamcinolone.acetonide, triamcinolone, halcinonide, hydrocortisone, desonide, beclomethasone.dipropionate, fluticasone.propionate, deflazacort, flumethasone.pivalate, piretanide, betamethasone, fluocinolone.acetonide, rimexolone, prednisolone.hemisuccinate",1.47108329972235,0.595166283380062,FALSE
+"H2009","Pearson.est","glutamate receptor antagonist",-0.45547,-1.11,0.357,850,0.837,"MTPG, JNJ.16259685, tiletamine, SIB.1757, latrepirdine, ACDPP, diazooxonorleucine",0.447331783887807,0.07727454200674,FALSE
+"H2009","Pearson.est","glycogen synthase kinase inhibitor",-0.49901,-1.22,0.243,881,0.891,"CHIR.99021, LY2090314, tideglusib, GSK.3.inhibitor.IX, kenpaullone, AZD2858",0.614393726401688,0.0501222959631252,FALSE
+"H2009","Pearson.est","growth factor receptor inhibitor",-0.39474,-0.965,0.506,885,0.876,"GSK1904529A, GSK1838705A, AZD3463, GW.441756",0.295849483160201,0.0574958938319193,FALSE
+"H2009","Pearson.est","HCV inhibitor",-0.61912,-1.51,0.0638,1268,0.525,"narlaprevir, PSI.7976, daclatasvir",1.19517932127884,0.279840696594043,FALSE
+"H2009","Pearson.est","HDAC inhibitor",-0.48424,-1.17,0.284,955,0.857,"dacinostat, givinostat, entinostat, nexturastat.a, chidamide, M.344, romidepsin, AR.42, R306465, PCI.24781, tacedinaline, panobinostat, vorinostat, SB.939, JNJ.26481585",0.546681659952962,0.0670191780768018,FALSE
+"H2009","Pearson.est","histamine receptor antagonist",-0.55278,-1.35,0.133,937,0.829,"tiotidine, ranitidine, cimetidine, levocetirizine, ICI.162846, lafutidine, cyproheptadine, famotidine, nizatidine, pheniramine, terfenadine, tecastemizole, chloropyramine, zolantidine",0.876148359032914,0.0814454694497265,FALSE
+"H2009","Pearson.est","HMGCR inhibitor",-0.40327,-0.988,0.488,1002,0.928,"simvastatin, mevastatin",0.311580177997289,0.0324520237811379,FALSE
+"H2009","Pearson.est","HSP inhibitor",-0.59206,-1.46,0.0642,1150,0.606,"VER.49009, XL888, tanespimycin, BIIB021, NVP.AUY922, SNX.2112, PU.H71, SNX.5422",1.19246497193115,0.217527375833714,FALSE
+"H2009","Pearson.est","JAK inhibitor",-0.39726,-0.974,0.495,1267,0.906,"pacritinib, atiprimod, CEP.33779, WHI.P154, LY2784544",0.305394801066431,0.0428718023231869,FALSE
+"H2009","Pearson.est","KIT inhibitor",0.27305,0.772,0.714,247,0.806,"lenvatinib, sorafenib, dasatinib, pazopanib, motesanib",0.146301788223826,0.0936649581949093,FALSE
+"H2009","Pearson.est","MDM inhibitor",-0.41922,-1.03,0.432,844,0.887,"RITA, nutlin.3, serdemetan",0.364516253185088,0.0520763801682736,FALSE
+"H2009","Pearson.est","MEK inhibitor",-0.36429,-0.901,0.575,745,0.873,"U.0126, PD.0325901, MEK162, AS.703026, cobimetinib, arctigenin, trametinib, PD.98059, Ro.4987655, TAK.733, PD.198306, BIX.02188, nobiletin",0.24033215531037,0.0589857562944303,FALSE
+"H2009","Pearson.est","MET inhibitor",-0.7088,-1.72,0.0121,1101,0.288,"LY2801653, PF.04217903, AMG458, NVP.BVU972, INC.280",1.91721462968355,0.540607512240769,FALSE
+"H2009","Pearson.est","microtubule inhibitor",-0.39681,-0.964,0.512,991,0.855,"estramustine.phosphate, D.64131, cabazitaxel, podophyllotoxin",0.290730039024169,0.0680338852718274,FALSE
+"H2009","Pearson.est","mTOR inhibitor",0.33091,0.936,0.514,199,0.883,"OSI.027, torin.1, voxtalisib, PF.04691502, WYE.354, XL388, WYE.125132, SB.2343, AZD2014, everolimus",0.289036881004724,0.0540392964224314,FALSE
+"H2009","Pearson.est","NFkB pathway inhibitor",0.31078,0.878,0.618,23,0.818,"EVP4593, tyloxapol",0.209011524911184,0.087246696328677,FALSE
+"H2009","Pearson.est","opioid receptor agonist",-0.39491,-0.969,0.495,1428,0.892,"salvinorin.a",0.305394801066431,0.0496351456238769,FALSE
+"H2009","Pearson.est","p38 MAPK inhibitor",-0.70047,-1.71,0.0161,1343,0.231,"VX.702, TAK.715, CMPD.1",1.79317412396815,0.636388020107856,TRUE
+"H2009","Pearson.est","PARP inhibitor",-0.55775,-1.38,0.124,1105,0.805,"talazoparib, olaparib, PJ.34, niraparib",0.906578314837765,0.0942041196321315,FALSE
+"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.38357,1.11,0.285,195,0.815,"lenvatinib, axitinib, ponatinib, linifanib, sorafenib, dasatinib, SU014813, dovitinib, pazopanib",0.54515513999149,0.0888423912600234,FALSE
+"H2009","Pearson.est","phosphatase inhibitor",0.33476,0.95,0.504,162,0.93,"GSK2830371, menadione, CID.5458317",0.297569463554475,0.0315170514460649,FALSE
+"H2009","Pearson.est","phosphodiesterase inhibitor",-0.45725,-1.12,0.32,1218,0.846,"cilostamide, zardaverine, YM.976, EMD.53998",0.494850021680094,0.0726296369609765,FALSE
+"H2009","Pearson.est","PI3K inhibitor",0.2959,0.841,0.65,184,0.785,"ZSTK.474, voxtalisib, PF.04691502, GDC.0941, PI3K.IN.2, buparlisib, SB.2343, idelalisib",0.187086643357144,0.105130343254747,FALSE
+"H2009","Pearson.est","PLK inhibitor",-0.49398,-1.22,0.216,827,0.891,"GW.843682X, GSK461364, HMN.214, BI.2536",0.665546248849069,0.0501222959631252,FALSE
+"H2009","Pearson.est","potassium channel blocker",-0.50472,-1.25,0.205,1178,0.977,"oleoylethanolamide, meglitinide",0.688246138944246,0.0101054362812269,FALSE
+"H2009","Pearson.est","PPAR receptor agonist",-0.19407,-0.466,0.991,910,1,"GW.501516, ciprofibrate, oleoylethanolamide",0.00392634551472468,0,FALSE
+"H2009","Pearson.est","progesterone receptor agonist",0.50753,1.4,0.15,152,0.639,"norethindrone, tanaproget, levonorgestrel",0.823908740944319,0.1944991418416,FALSE
+"H2009","Pearson.est","proteasome inhibitor",-0.65176,-1.62,0.0241,948,0.3,"MG.132, ONX.0914, carfilzomib, bortezomib, delanzomib, ixazomib.citrate, ixazomib",1.61798295742513,0.522878745280338,FALSE
+"H2009","Pearson.est","protein synthesis inhibitor",-0.23863,-0.58,0.942,998,1,"mercaptopurine, thiostrepton, brefeldin.a, puromycin, homoharringtonine, emetine",0.0259490972071227,0,FALSE
+"H2009","Pearson.est","protein tyrosine kinase inhibitor",0.4203,1.22,0.201,44,0.771,"mubritinib, PP.121",0.696803942579511,0.112945621949043,FALSE
+"H2009","Pearson.est","RAF inhibitor",-0.50506,-1.24,0.216,1273,0.942,"vemurafenib, GDC.0879, dabrafenib, LGX818, CEP.32496",0.665546248849069,0.0259490972071227,FALSE
+"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.23608,-0.574,0.949,858,1,"cabozantinib, vandetanib, apatinib",0.0227337875727074,0,FALSE
+"H2009","Pearson.est","retinoid receptor agonist",-0.42075,-1.04,0.409,1194,0.892,"tamibarotene, AM.580, CD.437",0.388276691992658,0.0496351456238769,FALSE
+"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.43952,-1.06,0.386,1152,0.94,"gemcitabine, fludarabine.phosphate, clofarabine, fludarabine",0.413412695328245,0.0268721464003014,FALSE
+"H2009","Pearson.est","serotonin receptor agonist",0.68981,1.98,0.0202,65,0.131,"aripiprazole, zolmitriptan",1.69464863055338,0.882728704344236,TRUE
+"H2009","Pearson.est","serotonin receptor antagonist",0.32412,0.926,0.528,2,0.839,"aripiprazole",0.277366077466188,0.0762380391712997,FALSE
+"H2009","Pearson.est","sodium channel blocker",-0.21328,-0.517,0.978,953,1,"lappaconite, mexiletine, butamben, ajmaline, triamterene",0.00966114521239857,0,FALSE
+"H2009","Pearson.est","src inhibitor",-0.36605,-0.898,0.605,1107,0.858,"saracatinib, KX2.391, bosutinib",0.218244625347531,0.0665127121512946,FALSE
+"H2009","Pearson.est","sterol demethylase inhibitor",-0.37498,-0.932,0.563,1244,0.878,"ketoconazole, lanoconazole",0.249491605148654,0.0565054840938974,FALSE
+"H2009","Pearson.est","TGF beta receptor inhibitor",-0.67055,-1.63,0.0267,1380,0.336,"D.4476, LY2109761",1.57348873863542,0.473660722610156,FALSE
+"H2009","Pearson.est","thymidylate synthase inhibitor",-0.72644,-1.79,0.00941,1262,0.454,"carmofur, raltitrexed, doxifluridine",2.02641037657274,0.342944147142896,FALSE
+"H2009","Pearson.est","topoisomerase inhibitor",-0.49982,-1.19,0.25,960,0.838,"TAS.103, teniposide, valrubicin, amonafide, etoposide, amsacrine, topotecan, nemorubicin, irinotecan, rubitecan, licochalcone.a, camptothecin, SN.38, genz.644282, exatecan.mesylate",0.602059991327962,0.0767559813697235,FALSE
+"H2009","Pearson.est","tubulin polymerization inhibitor",-0.32717,-0.81,0.707,668,0.914,"albendazole, ABT.751, flubendazole, docetaxel, BNC105, vincristine, indibulin, dolastatin.10, oxibendazole, vinorelbine, CYT.997, plinabulin, epothilone.b, mebendazole, fosbretabulin, epothilone.d, KX2.391, podophyllotoxin, taltobulin, combretastatin.A.4",0.150580586203101,0.0390538042661686,FALSE
+"H2009","Pearson.est","tyrosine kinase inhibitor",0.2191,0.629,0.911,149,0.901,"mubritinib, PP.121, sorafenib, GTP.14564, dasatinib",0.0404816230270017,0.045275209020937,FALSE
+"H2009","Pearson.est","VEGFR inhibitor",0.26266,0.752,0.786,278,0.795,"lenvatinib, axitinib, linifanib, semaxanib, sorafenib, SU014813, dovitinib, ENMD.2076, pazopanib, motesanib, ZM.306416, PD.173074",0.104577453960592,0.0996328713435297,FALSE
+"H2009","Pearson.est","vitamin D receptor agonist",-0.28173,-0.684,0.857,1416,1,"ercalcitriol",0.0670191780768018,0,FALSE
+"H2126","Pearson.est","EGFR inhibitor",-0.47556,-1.23,0.22,1178,0.541,"neratinib, CGP.52411, rociletinib, poziotinib, CNX.2006, vandetanib, BIBX.1382, BMS.599626, GW.583340, tucatinib, BIBU.1361, dacomitinib, pelitinib, PD.168393, PD.153035, AST.1306, OSI.420, CP.724714, WZ8040",0.657577319177794,0.266802734893431,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",0.35603,0.921,0.554,308,0.845,"GZD824, ponatinib, bafetinib, nilotinib, KW.2449, dasatinib",0.25649023527157,0.0731432910503077,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",-0.3372,-0.885,0.587,1416,0.826,"oxiracetam",0.231361898752386,0.0830199526796178,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",-0.49974,-1.28,0.191,904,0.653,"methscopolamine, darifenacin, dicycloverine, diphemanil",0.718966632752272,0.185086818724926,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.65258,-1.67,0.0342,1358,0.392,"MRS.1220, CGS.15943, istradefylline",1.46597389394386,0.406713932979543,FALSE
+"H2126","Pearson.est","adrenergic receptor agonist",0.3856,1.01,0.435,194,0.759,"epinephrine, terbutaline, norepinephrine, clenbuterol, buphenine",0.361510743045363,0.11975822410452,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",-0.24192,-0.636,0.889,1061,0.957,"prazosin, atenolol...., RS.17053, pindolol, imiloxan, dronedarone",0.0510982390297863,0.0190880622231565,FALSE
+"H2126","Pearson.est","AKT inhibitor",-0.44046,-1.13,0.334,1343,0.615,"CCT128930, A.674563, AT7867",0.476253533188435,0.211124884224583,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.58118,1.53,0.0851,349,0.414,"brigatinib, DMH1, alectinib, CEP.37440, crizotinib, SB.505124, lorlatinib",1.07007043991541,0.382999658879101,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",-0.56449,-1.42,0.122,814,0.679,"bicalutamide, flutamide, nilutamide, enzalutamide, cyproterone.acetate, RU.58841",0.913640169325252,0.168130225719498,FALSE
+"H2126","Pearson.est","antioxidant",-0.4806,-1.25,0.202,937,0.662,"trolox, taurine, benfotiamine",0.694648630553376,0.1791420105603,FALSE
+"H2126","Pearson.est","AP inhibitor",-0.58038,-1.48,0.1,1103,0.628,"LCL.161, embelin, tanshinone.i",1,0.202040356262804,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.47184,1.22,0.233,376,0.775,"digitoxigenin, oligomycin.a, digitoxin, rabeprazole, ouabain, NMS.873, k.strophanthidin",0.632644078973981,0.11069829749369,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.48744,1.31,0.166,394,0.753,"CCT137690, AMG900, barasertib, MK.8745, KW.2449, danusertib, GSK1070916, PF.03814735, barasertib.HQPA, ENMD.2076, SNS.314, MK.5108",0.779891911959945,0.123205023799299,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.29619,0.78,0.709,291,0.832,"azithromycin, tedizolid, josamycin",0.149353764816933,0.0798766737092761,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.36265,0.947,0.494,253,0.826,"finafloxacin, lomefloxacin, sparfloxacin",0.306273051076353,0.0830199526796178,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.2686,0.692,0.815,68,0.889,"oridonin",0.0888423912600234,0.0510982390297863,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.42072,1.08,0.343,308,0.796,"GZD824, ponatinib, bafetinib, nilotinib, dasatinib",0.464705879957229,0.0990869322623309,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",0.35236,0.905,0.56,145,0.79,"bentazepam, piperazine, ZK.93423",0.2518119729938,0.102372908709559,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",-0.4382,-1.13,0.317,1033,0.615,"I.BET.762, bromosporine",0.498940737782249,0.211124884224583,FALSE
+"H2126","Pearson.est","calcium channel blocker",-0.40838,-1.07,0.373,1126,0.636,"SKF.96365, tetrandrine, SR.33805, cinnarazine, mibefradil",0.428291168191312,0.196542884351586,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.78507,2.07,0.00209,35,0.0792,"UNBS.5162, ZK811752",2.67985371388895,1.10127481841051,TRUE
+"H2126","Pearson.est","CDK inhibitor",-0.43267,-1.1,0.345,1259,0.609,"ribociclib, dinaciclib, CR8..R., arcyriaflavin.a, AT.7519, TG.02, indirubin",0.462180904926726,0.215382707367125,FALSE
+"H2126","Pearson.est","CHK inhibitor",-0.40365,-1.05,0.412,1213,0.593,"AZD7762, CHIR.124",0.385102783966865,0.226945306635737,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.28339,-0.713,0.816,1281,0.914,"FR.122047, phenylbutazone, naproxen, tryptanthrin",0.0883098412461389,0.0390538042661686,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",0.37618,0.984,0.465,195,0.78,"eplerenone, clotrimazole, PF.4981517",0.332547047110046,0.10790539730952,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.32096,0.847,0.596,516,0.816,"dianhydrogalactitol, carmustine, carboplatin, melphalan, mitomycin.c, cyclophosphamide, temozolomide, estramustine, TH.302",0.224753740259764,0.0883098412461389,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.41373,1.07,0.349,292,0.776,"teroxirone, chlorambucil, carmustine, mechlorethamine, carboplatin, tirapazamine, melphalan",0.45717457304082,0.110138278741812,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",0.34514,0.911,0.554,252,0.835,"SGI.1027, decitabine",0.25649023527157,0.0783135245163979,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",-0.33698,-0.871,0.566,1106,0.821,"famciclovir, adefovir.dipivoxil, cidofovir",0.247183568811729,0.0856568428805592,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",-0.22905,-0.592,0.92,1091,0.925,"cisplatin, estramustine.phosphate, anisomycin, altretamine",0.0362121726544447,0.0338582672609674,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.40883,-1.06,0.377,978,0.601,"mesoridazine, amisulpride, UH.232...., oxiperomide, clebopride, acetophenazine, piperacetazine, nemonapride, remoxipride",0.423658649794207,0.22112552799726,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",0.27025,0.712,0.807,51,0.886,"estradiol.cypionate",0.0931264652779296,0.0525662781129492,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",-0.33018,-0.856,0.608,1384,0.82,"tamoxifen",0.216096420727265,0.0861861476162833,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.4432,1.14,0.299,91,0.801,"erdafitinib, dovitinib, regorafenib",0.52432881167557,0.0963674839157623,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.34316,0.891,0.555,337,0.789,"dovitinib, tyrphostin.AG.1296, ponatinib, sorafenib, KW.2449, gilteritinib, tandutinib, ENMD.2076",0.255707016877324,0.10292299679058,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",0.33695,0.88,0.599,448,0.784,"fluticasone.propionate, prednisolone, ciclesonide, prednisolone.hemisuccinate, flumethasone.pivalate, triamcinolone, fluocinolone.acetonide, halobetasol.propionate, desonide, triamcinolone.acetonide, clobetasol.propionate, prednisolone.acetate, betamethasone, fludroxycortide",0.222573177610689,0.105683937315562,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.30166,-0.774,0.716,1345,0.903,"latrepirdine, CPP",0.145086977692144,0.0443122496864942,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.5144,-1.29,0.207,1048,0.69,"AZD2858, CHIR.98014, kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin",0.684029654543082,0.161150909262745,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.60365,1.62,0.0587,75,0.367,"PHA.848125, GSK1838705A",1.23136189875239,0.435333935747911,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.41658,1.08,0.337,235,0.796,"narlaprevir, mericitabine, daclatasvir",0.472370099128661,0.0990869322623309,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.63079,-1.61,0.0609,1000,0.425,"RGFP966, AR.42, givinostat, dacinostat, resminostat, panobinostat, R306465, vorinostat, tacedinaline, PCI.24781, ACY.1215, RG2833, M.344, entinostat, mocetinostat, scriptaid, SB.939, romidepsin, JNJ.26481585",1.21538270736712,0.371611069949688,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",-0.45156,-1.16,0.29,1087,0.626,"tiotidine, astemizole, levocetirizine, famotidine, ranitidine, epinastine, BF2.649, tecastemizole, chloropyramine",0.537602002101044,0.20342566678957,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",-0.28918,-0.747,0.756,417,0.892,"pitavastatin, atorvastatin, fluvastatin, lovastatin, simvastatin, mevastatin",0.121478204498793,0.0496351456238769,FALSE
+"H2126","Pearson.est","HSP inhibitor",-0.40478,-1.06,0.388,1246,0.601,"alvespimycin, XL888, tanespimycin, VER.49009, KW.2478",0.411168274405793,0.22112552799726,FALSE
+"H2126","Pearson.est","JAK inhibitor",-0.28887,-0.751,0.766,1394,0.913,"TG.02, pacritinib",0.115771230367396,0.039529222465701,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.30687,0.795,0.66,308,0.831,"regorafenib, OSI.930, masitinib, sorafenib, tandutinib, dasatinib",0.180456064458131,0.080398976215889,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.54331,-1.41,0.123,1184,0.617,"idasanutlin, AMG.232, CGM097, RITA",0.910094888560602,0.209714835966758,FALSE
+"H2126","Pearson.est","MEK inhibitor",-0.30072,-0.786,0.687,1339,0.912,"nobiletin, selumetinib, BIX.02188",0.16304326294045,0.0400051616715838,FALSE
+"H2126","Pearson.est","MET inhibitor",0.4964,1.28,0.214,74,0.756,"LY2801653",0.669586226650809,0.121478204498793,FALSE
+"H2126","Pearson.est","microtubule inhibitor",-0.36566,-0.911,0.553,1188,0.808,"cytochalasin.b, triclabendazole, colchicine, estramustine.phosphate",0.257274868695302,0.0925886392254138,FALSE
+"H2126","Pearson.est","mTOR inhibitor",0.42238,1.09,0.343,262,0.866,"ku.0063794, PP242, AZD2014, SB.2343, PI.103, MLN0128, WYE.125132, OSI.027",0.464705879957229,0.0624821079826534,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.43049,-1.12,0.305,1260,0.603,"IKK.2.inhibitor.V, tyloxapol, Ro.106.9920, parthenolide",0.515700160653214,0.219682687859849,FALSE
+"H2126","Pearson.est","opioid receptor agonist",0.34591,0.909,0.541,132,0.81,"BW.180C, spiradoline",0.266802734893431,0.0915149811213502,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",0.45605,1.17,0.261,462,0.783,"talmapimod, CMPD.1, SB.239063, skepinone.l",0.583359492661719,0.106238237942057,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.39439,1.02,0.413,367,0.771,"olaparib, AZD2461, talazoparib, PJ.34, niraparib",0.384049948343599,0.112945621949043,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.30403,0.81,0.683,308,0.831,"dovitinib, regorafenib, ponatinib, masitinib, sorafenib, tandutinib, dasatinib",0.165579296318467,0.080398976215889,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.22685,0.574,0.944,265,0.964,"sodium.stibogluconate, alexidine",0.025028005701931,0.0159229660971692,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",-0.25485,-0.664,0.85,1211,0.951,"avanafil, anagrelide",0.0705810742857073,0.0218194830625861,FALSE
+"H2126","Pearson.est","PI3K inhibitor",0.25288,0.667,0.853,452,0.898,"buparlisib, SB.2343, PI.103, GDC.0941, CH5132799, PI3K.IN.2, ZSTK.474, BGT226, GDC.0980, NVP.BEZ235, PF.04691502",0.069050968832477,0.0467236633326956,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.79048,2.05,0,229,0.0482,"GW.843682X, HMN.214, NMS.1286937, volasertib, GSK461364, BI.2536",Inf,1.31695296176115,TRUE
+"H2126","Pearson.est","potassium channel blocker",-0.71752,-1.8,0.0135,1047,0.242,"dofetilide, oleoylethanolamide, ibutilide, ML133, mepivacaine",1.86966623150499,0.616184634019569,TRUE
+"H2126","Pearson.est","PPAR receptor agonist",-0.47535,-1.23,0.228,1028,0.541,"pterostilbene, oleoylethanolamide, clofibrate, S26948, GW.501516",0.642065152999546,0.266802734893431,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",0.31772,0.831,0.643,469,0.82,"nomegestrol.acetate, melengestrol.acetate, norgestrel, tanaproget",0.191789027075778,0.0861861476162833,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.68121,1.79,0.0178,60,0.202,"MG.132, delanzomib",1.74957999769111,0.694648630553376,TRUE
+"H2126","Pearson.est","protein synthesis inhibitor",0.40305,1.04,0.41,438,0.804,"clofoctol, cycloheximide, mercaptopurine, thiostrepton, chloramphenicol.palmitate, puromycin, methacycline, clindamycin.phosphate",0.387216143280265,0.0947439512515487,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.51192,-1.29,0.194,1095,0.69,"rheochrysidin, BMS.599626, AV.412, CP.724714",0.712198270069774,0.161150909262745,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.47008,1.22,0.216,320,0.775,"RAF265, SB.590885, regorafenib, sorafenib, PLX.4720, vemurafenib",0.665546248849069,0.11069829749369,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.45018,1.18,0.277,168,0.815,"regorafenib, sorafenib",0.557520230935551,0.0888423912600234,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.5962,1.54,0.0743,287,0.454,"adapalene, tamibarotene, LE.135",1.12901118623942,0.342944147142896,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.50627,1.35,0.157,368,0.73,"hydroxyurea, cladribine, triapine, cytarabine, fludarabine.phosphate",0.804100347590766,0.136677139879544,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",-0.77708,-1.98,0,1447,0.167,"aripiprazole",Inf,0.777283528852417,TRUE
+"H2126","Pearson.est","serotonin receptor antagonist",-0.46938,-1.23,0.234,1447,0.541,"aripiprazole",0.630784142589857,0.266802734893431,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.28374,0.745,0.774,69,0.86,"brivaracetam, benzocaine",0.111259039317107,0.0655015487564323,FALSE
+"H2126","Pearson.est","src inhibitor",-0.47521,-1.24,0.225,1237,0.636,"TG.100572, bosutinib, PP.2, ZM.306416",0.647817481888638,0.196542884351586,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.73677,1.9,0.0168,110,0.126,"chlormidazole, lanoconazole, sulconazole",1.77469071827414,0.899629454882437,TRUE
+"H2126","Pearson.est","TGF beta receptor inhibitor",-0.73176,-1.89,0.013,1393,0.175,"SB.431542, SB.525334, repsox",1.88605664769316,0.756961951313706,TRUE
+"H2126","Pearson.est","thymidylate synthase inhibitor",-0.23857,-0.611,0.908,1134,0.932,"carmofur, doxifluridine",0.0419141514789149,0.0305840876460186,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.65679,1.72,0.0352,416,0.259,"mitoxantrone, topotecan, amsacrine, etoposide.phosphate, doxorubicin, exatecan.mesylate, idarubicin, TAS.103, genz.644282, dexrazoxane, etoposide, voreloxin, epirubicin, nemorubicin, SN.38, rubitecan, beta.lapachone, daunorubicin, amonafide, valrubicin, irinotecan",1.45345733652187,0.586700235918748,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.40124,1.03,0.406,449,0.787,"BNC105, mebendazole, taltobulin, verubulin, vinblastine, fenbendazole, oxibendazole, albendazole, flubendazole, indibulin, podophyllotoxin, paclitaxel",0.391473966422806,0.104025267640935,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",-0.25222,-0.627,0.842,1222,0.941,"AMG.208, vandetanib, BMS.599626, GTP.14564, AV.412, CP.724714",0.0746879085003505,0.0264103765727431,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",0.21048,0.538,0.954,217,0.963,"RAF265, dovitinib, regorafenib, OSI.930, tivozanib, sorafenib, foretinib",0.0204516252959049,0.0163737128754655,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.5224,-1.33,0.179,1158,0.734,"alfacalcidol, tacalcitol, paricalcitol",0.747146969020107,0.134303940083929,FALSE
+"H3255","Pearson.est","EGFR inhibitor",-0.56906,-1.42,0.117,1044,0.726,"rociletinib, CUDC.101, GW.583340, BMS.599626, BIBX.1382, XL.647, BMS.690514, CP.724714, vandetanib, TAK.285, tucatinib, neratinib, lapatinib, tyrphostin.AG.1478, AEE788, OSI.420, PD.153035, gefitinib, PD.168393, WZ8040, canertinib, icotinib, afatinib, pelitinib, BIBU.1361, osimertinib, erlotinib",0.931814138253838,0.139063379299906,FALSE
+"H3255","Pearson.est","Abl kinase inhibitor",0.29335,0.769,0.755,225,0.881,"GZD824, dasatinib, ponatinib, flumatinib",0.122053048370812,0.0550240915879521,FALSE
+"H3255","Pearson.est","acetylcholine receptor agonist",0.43467,1.18,0.239,138,0.915,"nicotine, xanomeline",0.621602099051862,0.0385789059335517,FALSE
+"H3255","Pearson.est","acetylcholine receptor antagonist",-0.32041,-0.79,0.708,1400,0.898,"diphemanil",0.149966742310231,0.0467236633326956,FALSE
+"H3255","Pearson.est","adenosine receptor antagonist",-0.40494,-0.986,0.471,849,1,"sulmazole, PSB.1115, SCH.58261, MRS.1220, CGS.15943",0.326979092871104,0,FALSE
+"H3255","Pearson.est","adrenergic receptor agonist",-0.17542,-0.434,0.997,878,0.994,"A61603, clenbuterol, methyldopa, oxymetazoline, isoxsuprine, epinephrine",0.00130484168834428,0.00261361560268669,FALSE
+"H3255","Pearson.est","adrenergic receptor antagonist",-0.338,-0.833,0.681,1191,0.966,"pindolol, vincamine, RS.17053, carvedilol, levobunolol, dronedarone",0.166852888087215,0.0150228735845067,FALSE
+"H3255","Pearson.est","AKT inhibitor",-0.40233,-0.981,0.476,1169,0.99,"CCT128930, uprosertib, triciribine, palomid.529",0.322393047279507,0.00436480540245009,FALSE
+"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.39296,-0.966,0.499,984,0.922,"GW.788388, CEP.37440, NVP.TAE684, AZD3463",0.30189945437661,0.0352690789463706,FALSE
+"H3255","Pearson.est","androgen receptor antagonist",0.29768,0.778,0.716,251,0.945,"RU.58841, enzalutamide",0.145086977692144,0.0245681914907371,FALSE
+"H3255","Pearson.est","antioxidant",0.47181,1.24,0.21,13,1,"trolox",0.677780705266081,0,FALSE
+"H3255","Pearson.est","AP inhibitor",-0.44779,-1.1,0.365,948,0.814,"embelin, birinapant, tanshinone.i, GDC.0152, LCL.161",0.437707135543525,0.0893755951107988,FALSE
+"H3255","Pearson.est","ATPase inhibitor",0.63185,1.7,0.034,406,0.58,"k.strophanthidin, oligomycin.a, evodiamine, digoxin, NMS.873, digitoxigenin, rabeprazole, omeprazole, blebbistatin....",1.46852108295774,0.236572006437063,FALSE
+"H3255","Pearson.est","Aurora kinase inhibitor",0.41787,1.11,0.348,345,0.909,"AT.9283, CYC116, barasertib.HQPA, SNS.314, barasertib, TAK.901, ENMD.2076, CCT129202, aurora.a.inhibitor.i, AMG900",0.458420756053419,0.0414361167780325,FALSE
+"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34904,-0.876,0.61,1323,0.964,"azalomycin.b, azithromycin",0.214670164989233,0.0159229660971692,FALSE
+"H3255","Pearson.est","bacterial DNA gyrase inhibitor",-0.24822,-0.605,0.909,888,0.991,"sparfloxacin, sarafloxacin, novobiocin, trovafloxacin",0.0414361167780325,0.00392634551472468,FALSE
+"H3255","Pearson.est","BCL inhibitor",0.33892,0.903,0.563,381,0.937,"ABT.737, gossypol, TW.37, venetoclax, obatoclax",0.249491605148654,0.0282604091122217,FALSE
+"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.31182,0.824,0.686,225,0.948,"GZD824, dasatinib, ponatinib, flumatinib",0.163675884293248,0.0231916626619338,FALSE
+"H3255","Pearson.est","benzodiazepine receptor agonist",-0.37427,-0.903,0.581,935,0.937,"indiplon, bentazepam, CGS.20625, ZK.93423, zaleplon",0.235823867609669,0.0282604091122217,FALSE
+"H3255","Pearson.est","bromodomain inhibitor",-0.23578,-0.579,0.944,340,0.974,"OTX015, PFI.1, I.BET.762, I.BET151, bromosporine, JQ1....",0.025028005701931,0.0114410431213845,FALSE
+"H3255","Pearson.est","calcium channel blocker",0.24409,0.666,0.886,1097,1,"efonidipine.monoethanolate, carboxyamidotriazole, SR.33805, pranidipine, mibefradil, cinnarazine, SKF.96365, penfluridol, tetrandrine, fendiline",0.0525662781129492,0,FALSE
+"H3255","Pearson.est","CC chemokine receptor antagonist",-0.29789,-0.742,0.809,1422,0.951,"navarixin",0.0920514783877277,0.0218194830625861,FALSE
+"H3255","Pearson.est","CDK inhibitor",-0.34387,-0.833,0.66,975,0.966,"BMS.265246, CR8..R., JNJ.7706621, PHA.793887, BMS.387032, AZD5438, kenpaullone, alvocidib, arcyriaflavin.a",0.180456064458131,0.0150228735845067,FALSE
+"H3255","Pearson.est","CHK inhibitor",-0.51598,-1.28,0.203,955,0.648,"CHIR.124, SCH.900776, LY2606368, LY2603618",0.692503962086787,0.188424994129407,FALSE
+"H3255","Pearson.est","cyclooxygenase inhibitor",-0.33583,-0.821,0.666,1140,0.913,"FR.122047, suxibuzone, indoprofen, ramifenazone, AM.404, FK.3311",0.176525770829699,0.039529222465701,FALSE
+"H3255","Pearson.est","cytochrome P450 inhibitor",0.45553,1.2,0.241,298,1,"metyrapone, itraconazole, morin, eplerenone",0.617982957425132,0,FALSE
+"H3255","Pearson.est","DNA alkylating agent",-0.38283,-0.949,0.542,1224,0.928,"mitomycin.c, ifosfamide, melphalan, dacarbazine",0.266000713461613,0.0324520237811379,FALSE
+"H3255","Pearson.est","DNA inhibitor",-0.23839,-0.595,0.934,940,0.98,"valrubicin, sangivamycin, busulfan, nithiamide, bendamustine, primaquine, melphalan",0.0296531237699066,0.00877392430750515,FALSE
+"H3255","Pearson.est","DNA methyltransferase inhibitor",-0.77542,-1.88,0.00159,1159,0.243,"decitabine, SGI.1027, fdcyd, azacitidine",2.79860287567955,0.614393726401688,TRUE
+"H3255","Pearson.est","DNA polymerase inhibitor",0.32569,0.872,0.56,979,0.948,"famciclovir, foscarnet, adefovir.dipivoxil, cidofovir, menadione, idoxuridine, trifluridine, cephalomannine",0.2518119729938,0.0231916626619338,FALSE
+"H3255","Pearson.est","DNA synthesis inhibitor",-0.33305,-0.826,0.665,1056,0.928,"capecitabine, enocitabine, anisomycin, mitomycin.c, altretamine, floxuridine",0.177178354696895,0.0324520237811379,FALSE
+"H3255","Pearson.est","dopamine receptor antagonist",0.24038,0.651,0.872,255,0.944,"thioproperazine, remoxipride, domperidone, raclopride, nemonapride, clebopride",0.0594835150674328,0.025028005701931,FALSE
+"H3255","Pearson.est","estrogen receptor agonist",0.42912,1.16,0.269,430,0.865,"estrone, erteberel, levonorgestrel, estradiol.cypionate, ethinyl.estradiol",0.570247719997592,0.0629838925351858,FALSE
+"H3255","Pearson.est","estrogen receptor antagonist",0.38288,1.04,0.371,81,0.79,"tamoxifen",0.430626090384954,0.102372908709559,FALSE
+"H3255","Pearson.est","FGFR inhibitor",0.31277,0.835,0.664,203,0.974,"erdafitinib, nintedanib, lenvatinib",0.177831920631982,0.0114410431213845,FALSE
+"H3255","Pearson.est","FLT3 inhibitor",0.23836,0.663,0.87,310,0.966,"tyrphostin.AG.1296, ponatinib, GTP.14564, ENMD.2076, TG.101348",0.0604807473813815,0.0150228735845067,FALSE
+"H3255","Pearson.est","glucocorticoid receptor agonist",0.58493,1.59,0.0665,105,0.611,"hydrocortisone, dexamethasone.acetate, triamcinolone, beclomethasone.dipropionate, fluticasone.propionate, piretanide, desonide, halcinonide",1.1771783546969,0.213958789757446,FALSE
+"H3255","Pearson.est","glutamate receptor antagonist",-0.46282,-1.15,0.286,1277,0.734,"MTPG, diazooxonorleucine, ACDPP",0.543633966870957,0.134303940083929,FALSE
+"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.51666,-1.29,0.182,1148,0.666,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, AZD2858",0.739928612014925,0.176525770829699,FALSE
+"H3255","Pearson.est","growth factor receptor inhibitor",-0.39087,-0.972,0.482,1031,0.941,"GSK1838705A, AZD3463, GW.441756",0.31695296176115,0.0264103765727431,FALSE
+"H3255","Pearson.est","HCV inhibitor",-0.6267,-1.55,0.0466,916,0.738,"narlaprevir, embelin, Ro.9187, PSI.7976, daclatasvir",1.33161408331,0.131943638176958,FALSE
+"H3255","Pearson.est","HDAC inhibitor",-0.58413,-1.45,0.0806,1081,0.996,"pyroxamide, M.344, AR.42, givinostat, nexturastat.a, entinostat, vorinostat, romidepsin, chidamide, tacedinaline, R306465, PCI.24781, panobinostat, JNJ.26481585, SB.939",1.09366495819491,0.00174066157630127,FALSE
+"H3255","Pearson.est","histamine receptor antagonist",-0.57888,-1.42,0.122,1073,0.726,"nizatidine, astemizole, terfenadine, levocetirizine, ranitidine, tecastemizole, chloropyramine, cyproheptadine, zolantidine",0.913640169325252,0.139063379299906,FALSE
+"H3255","Pearson.est","HMGCR inhibitor",-0.2555,-0.626,0.889,1036,0.991,"simvastatin, mevastatin",0.0510982390297863,0.00392634551472468,FALSE
+"H3255","Pearson.est","HSP inhibitor",-0.53476,-1.33,0.147,1011,0.609,"BIIB021, VER.49009, SNX.2112, NVP.AUY922, PU.H71, tanespimycin, alvespimycin, XL888, SNX.5422",0.832682665251824,0.215382707367125,FALSE
+"H3255","Pearson.est","JAK inhibitor",-0.22583,-0.556,0.954,1274,0.97,"pacritinib, atiprimod, LY2784544",0.0204516252959049,0.0132282657337552,FALSE
+"H3255","Pearson.est","KIT inhibitor",-0.29455,-0.717,0.814,905,0.922,"imatinib, vatalanib, regorafenib, motesanib, OSI.930, telatinib, tandutinib",0.0893755951107988,0.0352690789463706,FALSE
+"H3255","Pearson.est","MDM inhibitor",0.23743,0.626,0.912,86,0.905,"AMG.232",0.0400051616715838,0.0433514207947967,FALSE
+"H3255","Pearson.est","MEK inhibitor",0.29586,0.804,0.673,122,0.942,"PD.318088, refametinib, MEK1.2.inhibitor",0.171984935776023,0.0259490972071227,FALSE
+"H3255","Pearson.est","MET inhibitor",-0.48433,-1.2,0.248,980,0.688,"NVP.BVU972, AMG458, INC.280",0.605548319173784,0.162411561764489,FALSE
+"H3255","Pearson.est","microtubule inhibitor",-0.33254,-0.811,0.666,933,0.907,"estramustine.phosphate, vinflunine, cabazitaxel, D.64131, podophyllotoxin",0.176525770829699,0.0423927129399047,FALSE
+"H3255","Pearson.est","mTOR inhibitor",0.38209,1,0.439,193,0.826,"torin.1, OSI.027, SB.2343, WYE.354, WYE.125132, PF.04691502, PKI.179, voxtalisib, AZD2014",0.357535479757879,0.0830199526796178,FALSE
+"H3255","Pearson.est","NFkB pathway inhibitor",0.41192,1.1,0.312,54,0.853,"EVP4593, tyloxapol",0.505845405981557,0.069050968832477,FALSE
+"H3255","Pearson.est","opioid receptor agonist",-0.39348,-0.98,0.478,1395,0.956,"salvinorin.a",0.320572103387881,0.0195421077238999,FALSE
+"H3255","Pearson.est","p38 MAPK inhibitor",-0.49154,-1.2,0.262,1078,0.688,"SB.239063, VX.702, TAK.715, CMPD.1",0.581698708680255,0.162411561764489,FALSE
+"H3255","Pearson.est","PARP inhibitor",-0.56588,-1.38,0.13,925,0.578,"AZD2461, E7449, olaparib, PJ.34, talazoparib, niraparib",0.886056647693163,0.238072161579471,FALSE
+"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.24029,0.627,0.894,212,0.937,"nintedanib, linifanib, axitinib, lenvatinib, dasatinib, ponatinib",0.0486624812040823,0.0282604091122217,FALSE
+"H3255","Pearson.est","phosphatase inhibitor",-0.30434,-0.734,0.8,1015,0.92,"mycophenolic.acid, mycophenolate.mofetil, sodium.stibogluconate, AS.1949490",0.0969100130080564,0.0362121726544447,FALSE
+"H3255","Pearson.est","phosphodiesterase inhibitor",-0.58397,-1.44,0.11,1099,0.873,"GSK256066, trequinsin, EMD.53998, YM.976, papaverine, zardaverine, cilostamide",0.958607314841775,0.0589857562944303,FALSE
+"H3255","Pearson.est","PI3K inhibitor",0.36945,0.979,0.466,191,0.82,"GDC.0941, SB.2343, buparlisib, PF.04691502, ZSTK.474, PKI.179, voxtalisib",0.33161408331,0.0861861476162833,FALSE
+"H3255","Pearson.est","PLK inhibitor",-0.56134,-1.4,0.105,1018,0.635,"HMN.214, GSK461364, BI.2536",0.978810700930062,0.197226274708024,FALSE
+"H3255","Pearson.est","potassium channel blocker",-0.34691,-0.85,0.644,1120,0.988,"meglitinide, oleoylethanolamide",0.191114132640188,0.00524305541237188,FALSE
+"H3255","Pearson.est","PPAR receptor agonist",0.44148,1.18,0.277,38,0.915,"fenofibrate, clofibrate",0.557520230935551,0.0385789059335517,FALSE
+"H3255","Pearson.est","progesterone receptor agonist",0.61949,1.7,0.0309,125,0.58,"tanaproget, norethindrone, nomegestrol.acetate",1.51004152057517,0.236572006437063,FALSE
+"H3255","Pearson.est","proteasome inhibitor",-0.68074,-1.65,0.0258,1026,0.823,"ONX.0914, MG.132, delanzomib, carfilzomib, ixazomib, bortezomib, ixazomib.citrate",1.58838029403677,0.0846001647877302,FALSE
+"H3255","Pearson.est","protein synthesis inhibitor",-0.32834,-0.81,0.694,1165,0.887,"puromycin, brefeldin.a, azomycin..2.nitroimidazole., homoharringtonine, emetine",0.158640529545145,0.0520763801682736,FALSE
+"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.29208,0.775,0.721,119,0.909,"mubritinib, PP.121",0.142064735280571,0.0414361167780325,FALSE
+"H3255","Pearson.est","RAF inhibitor",-0.5613,-1.39,0.13,1068,0.605,"RAF265, SB.590885, vemurafenib, LGX818, dabrafenib, GDC.0879, CEP.32496",0.886056647693163,0.218244625347531,FALSE
+"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.48579,-1.2,0.249,1223,0.688,"vandetanib, apatinib",0.603800652904264,0.162411561764489,FALSE
+"H3255","Pearson.est","retinoid receptor agonist",-0.55544,-1.36,0.153,1240,0.582,"tamibarotene, adarotene, AM.580, CD.437",0.815308569182401,0.235077015350112,FALSE
+"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.495,-1.22,0.238,1142,0.757,"fludarabine.phosphate, gemcitabine, clofarabine, fludarabine",0.623423042943488,0.120904120499927,FALSE
+"H3255","Pearson.est","serotonin receptor agonist",0.40237,1.06,0.371,379,0.872,"zolmitriptan, aripiprazole, NAN.190, SR.57227A",0.430626090384954,0.0594835150674328,FALSE
+"H3255","Pearson.est","serotonin receptor antagonist",-0.32922,-0.828,0.663,1048,0.949,"RS.16566, sertindole, ziprasidone, SB.228357",0.178486471595227,0.0227337875727074,FALSE
+"H3255","Pearson.est","sodium channel blocker",0.39238,1.05,0.377,66,0.827,"oxcarbazepine, benzethonium, cibenzoline",0.423658649794207,0.0824944904474534,FALSE
+"H3255","Pearson.est","src inhibitor",-0.36674,-0.907,0.577,1112,0.958,"TG.100572, KX2.391, saracatinib",0.238824186844269,0.0186344909214556,FALSE
+"H3255","Pearson.est","sterol demethylase inhibitor",0.56571,1.53,0.0803,114,0.585,"sulconazole, posaconazole, terconazole",1.09528445472132,0.23284413391782,FALSE
+"H3255","Pearson.est","TGF beta receptor inhibitor",-0.38004,-0.943,0.529,1040,0.911,"repsox, D.4476, LY2109761",0.276544327964814,0.0404816230270017,FALSE
+"H3255","Pearson.est","thymidylate synthase inhibitor",-0.64127,-1.61,0.0563,1288,0.702,"carmofur, raltitrexed, doxifluridine",1.24949160514865,0.153662887870195,FALSE
+"H3255","Pearson.est","topoisomerase inhibitor",-0.57679,-1.41,0.113,1262,0.676,"nemorubicin, topotecan, licochalcone.a, rubitecan, SN.38, irinotecan, camptothecin, genz.644282, exatecan.mesylate",0.94692155651658,0.170053304058364,FALSE
+"H3255","Pearson.est","tubulin polymerization inhibitor",-0.47778,-1.19,0.265,874,0.678,"epothilone.b, ABT.751, indibulin, albendazole, flubendazole, CYT.997, vinorelbine, vincristine, dolastatin.10, plinabulin, parbendazole, mebendazole, KX2.391, fosbretabulin, podophyllotoxin, taltobulin, combretastatin.A.4",0.576754126063192,0.168770306132937,FALSE
+"H3255","Pearson.est","tyrosine kinase inhibitor",-0.30688,-0.74,0.778,1070,0.932,"hypericin, BMS.599626, CP.724714, AV.412, tyrphostin.A9, vandetanib, apatinib, tivantinib, bafetinib, AMG.208",0.109020403010311,0.0305840876460186,FALSE
+"H3255","Pearson.est","VEGFR inhibitor",-0.27547,-0.671,0.849,952,0.96,"vatalanib, regorafenib, motesanib, foretinib, OSI.930, RAF265, telatinib, TG.100572, golvatinib, XL.647, BMS.690514, MGCD.265, vandetanib, lucitanib, orantinib, AEE788",0.0710923097560473,0.0177287669604316,FALSE
+"H3255","Pearson.est","vitamin D receptor agonist",-0.43686,-1.07,0.397,1195,0.847,"maxacalcitol, calcitriol, ercalcitriol",0.401209493236885,0.0721165896692931,FALSE
+"H358","Pearson.est","EGFR inhibitor",-0.58942,-1.48,0.0893,1173,0.631,"PD.168393, AEE788, OSI.420, ARRY.334543, BMS.690514, vandetanib, tucatinib, GW.583340, BIBU.1361, rociletinib, PD.153035, TAK.285, erlotinib, lapatinib, dacomitinib, canertinib, neratinib, tyrphostin.AG.1478, WZ8040, icotinib, gefitinib, osimertinib, pelitinib, afatinib",1.04914854111145,0.199970640755866,FALSE
+"H358","Pearson.est","Abl kinase inhibitor",0.20667,0.569,0.932,361,1,"ponatinib, flumatinib, GZD824, ZM.306416, dasatinib",0.0305840876460186,0,FALSE
+"H358","Pearson.est","acetylcholine receptor agonist",0.56734,1.54,0.0642,306,0.589,"xanomeline, nefiracetam",1.19246497193115,0.229884705212898,FALSE
+"H358","Pearson.est","acetylcholine receptor antagonist",-0.43031,-1.07,0.371,1398,0.71,"dicycloverine",0.430626090384954,0.148741651280925,FALSE
+"H358","Pearson.est","adenosine receptor antagonist",-0.52306,-1.3,0.202,1072,0.557,"sulmazole, theophylline, CGS.15943",0.694648630553376,0.254144804826271,FALSE
+"H358","Pearson.est","adrenergic receptor agonist",-0.49634,-1.24,0.219,971,0.619,"methyldopa, epinephrine, midodrine, norepinephrine, oxymetazoline, metaraminol, clenbuterol, terbutaline, A61603, isoxsuprine",0.659555885159882,0.208309350979882,FALSE
+"H358","Pearson.est","adrenergic receptor antagonist",-0.37035,-0.935,0.528,1305,0.849,"pindolol, vincamine, levobunolol, dronedarone",0.277366077466188,0.0710923097560473,FALSE
+"H358","Pearson.est","AKT inhibitor",-0.47511,-1.21,0.229,1158,0.565,"CCT128930, palomid.529, ONC201, triciribine, uprosertib",0.640164517660112,0.247951552180562,FALSE
+"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.29784,0.803,0.691,1020,1,"alectinib, brigatinib, DMH1, SB.505124, lorlatinib, AZD3463, NVP.TAE684, AP26113, GW.788388, CEP.37440, crizotinib",0.160521952625802,0,FALSE
+"H358","Pearson.est","androgen receptor antagonist",-0.26608,-0.666,0.866,752,0.989,"enzalutamide, nilutamide, flutamide, bicalutamide, cyproterone.acetate",0.0624821079826534,0.0048037084028206,FALSE
+"H358","Pearson.est","antioxidant",0.52226,1.41,0.118,10,0.629,"trolox",0.928117992693875,0.201349354554731,FALSE
+"H358","Pearson.est","AP inhibitor",-0.41149,-1.03,0.425,931,0.738,"GDC.0152, tanshinone.i, LCL.161, embelin",0.371611069949688,0.131943638176958,FALSE
+"H358","Pearson.est","ATPase inhibitor",0.64878,1.71,0.0362,106,0.389,"k.strophanthidin, oligomycin.a, NMS.873, blebbistatin....",1.44129142946683,0.410050398674292,FALSE
+"H358","Pearson.est","Aurora kinase inhibitor",0.24466,0.645,0.856,481,1,"CYC116, CCT129202, AT.9283, barasertib.HQPA, PHA.680632, ENMD.2076, CCT137690, TAK.901, danusertib, SNS.314, GSK1070916, KW.2449, AMG900",0.0675262353228468,0,FALSE
+"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.29415,0.783,0.719,24,1,"radezolid",0.143271109617117,0,FALSE
+"H358","Pearson.est","bacterial DNA gyrase inhibitor",-0.34281,-0.881,0.602,1224,0.813,"trovafloxacin, lomefloxacin, sparfloxacin",0.220403508742175,0.0899094544059319,FALSE
+"H358","Pearson.est","BCL inhibitor",0.22292,0.611,0.929,1127,1,"gossypol, ABT.737, TW.37, venetoclax, HA14.1, oridonin, navitoclax, obatoclax",0.0319842860063582,0,FALSE
+"H358","Pearson.est","Bcr.Abl kinase inhibitor",0.18727,0.496,0.979,250,0.982,"ponatinib, flumatinib, GZD824",0.00921730819686218,0.00788851221305034,FALSE
+"H358","Pearson.est","benzodiazepine receptor agonist",-0.21344,-0.53,0.958,765,1,"CL.218872, ZK.93423, temazepam, CGS.20625, indiplon, zaleplon",0.0186344909214556,0,FALSE
+"H358","Pearson.est","bromodomain inhibitor",-0.65405,-1.63,0.0321,1172,0.39,"bromosporine, I.BET151, JQ1...., I.BET.762",1.49349496759513,0.408935392973501,FALSE
+"H358","Pearson.est","calcium channel blocker",0.29852,0.814,0.677,178,1,"efonidipine.monoethanolate, carboxyamidotriazole, pranidipine",0.169411331314856,0,FALSE
+"H358","Pearson.est","CC chemokine receptor antagonist",-0.33579,-0.854,0.624,1133,0.837,"PF.04136309, MK.0812, navarixin",0.204815410317576,0.07727454200674,FALSE
+"H358","Pearson.est","CDK inhibitor",-0.38739,-0.954,0.502,962,0.865,"BMS.265246, TG.02, JNJ.7706621, AZD5438, dinaciclib, P276.00, BMS.387032, kenpaullone, PHA.793887, arcyriaflavin.a, alvocidib, CR8..R.",0.299296282854981,0.0629838925351858,FALSE
+"H358","Pearson.est","CHK inhibitor",-0.54615,-1.38,0.137,787,0.58,"AZD7762, SB.218078, PF.477736, CHIR.124, LY2603618, SCH.900776, LY2606368",0.863279432843593,0.236572006437063,FALSE
+"H358","Pearson.est","cyclooxygenase inhibitor",-0.20124,-0.514,0.981,963,1,"tryptanthrin, curcumin, amfenac, AM.404, meloxicam, indoprofen, ramifenazone, FK.3311",0.0083309926200515,0,FALSE
+"H358","Pearson.est","cytochrome P450 inhibitor",0.19084,0.522,0.981,434,1,"eplerenone, morin, PF.4981517, metyrapone",0.0083309926200515,0,FALSE
+"H358","Pearson.est","DNA alkylating agent",-0.54772,-1.38,0.135,1096,0.58,"dianhydrogalactitol, mitomycin.c, ifosfamide, estramustine, cisplatin, satraplatin, melphalan, dacarbazine",0.869666231504994,0.236572006437063,FALSE
+"H358","Pearson.est","DNA inhibitor",0.32091,0.874,0.582,163,1,"carboplatin, oxaliplatin, mechlorethamine, metronidazole, teroxirone",0.235077015350112,0,FALSE
+"H358","Pearson.est","DNA methyltransferase inhibitor",-0.71586,-1.82,0.00479,1425,0.507,"fdcyd, azacitidine",2.31966448658544,0.294992040666664,FALSE
+"H358","Pearson.est","DNA polymerase inhibitor",-0.58173,-1.45,0.0963,917,0.566,"cephalomannine, adefovir.dipivoxil, trifluridine, cidofovir",1.01637371287547,0.247183568811729,FALSE
+"H358","Pearson.est","DNA synthesis inhibitor",-0.32684,-0.796,0.689,1065,0.912,"anisomycin, mitomycin.c, floxuridine, altretamine, cisplatin",0.161780778092374,0.0400051616715838,FALSE
+"H358","Pearson.est","dopamine receptor antagonist",-0.23506,-0.595,0.931,916,1,"mesoridazine, nemonapride, piperacetazine, ziprasidone, amisulpride, sertindole, acetophenazine, isofloxythepin",0.0310503190186574,0,FALSE
+"H358","Pearson.est","estrogen receptor agonist",-0.35591,-0.894,0.569,1199,0.835,"equol, estradiol, PPT",0.244887733604929,0.0783135245163979,FALSE
+"H358","Pearson.est","estrogen receptor antagonist",-0.29569,-0.741,0.784,1020,0.953,"toremifene, raloxifene",0.105683937315562,0.0209070993616736,FALSE
+"H358","Pearson.est","FGFR inhibitor",0.43707,1.19,0.254,112,0.687,"AZD4547, nintedanib, erdafitinib",0.595166283380062,0.16304326294045,FALSE
+"H358","Pearson.est","FLT3 inhibitor",-0.18557,-0.468,0.978,1281,0.987,"tandutinib, pacritinib",0.00966114521239857,0.00568284733036327,FALSE
+"H358","Pearson.est","glucocorticoid receptor agonist",0.67554,1.84,0.0265,162,0.303,"dexamethasone.acetate, hydrocortisone, desonide, beclomethasone.dipropionate, rimexolone, triamcinolone.acetonide, halcinonide, flumethasone.pivalate, fluticasone.propionate, triamcinolone, ciclesonide, deflazacort, fluocinolone.acetonide, betamethasone, clobetasol.propionate",1.57675412606319,0.518557371497695,FALSE
+"H358","Pearson.est","glutamate receptor antagonist",-0.46099,-1.17,0.284,1343,0.589,"ACDPP, LY456236, diazooxonorleucine",0.546681659952962,0.229884705212898,FALSE
+"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.54895,-1.37,0.136,1270,0.558,"kenpaullone, GSK.3.inhibitor.IX, AZD2858",0.866461091629782,0.253365801062421,FALSE
+"H358","Pearson.est","growth factor receptor inhibitor",0.42493,1.17,0.282,424,0.671,"PHA.848125, GSK1904529A, lestaurtinib, danusertib",0.549750891680639,0.173277479831008,FALSE
+"H358","Pearson.est","HCV inhibitor",-0.58478,-1.46,0.101,1193,0.608,"daclatasvir, PSI.7976, Ro.9187, embelin",0.995678626217357,0.216096420727265,FALSE
+"H358","Pearson.est","HDAC inhibitor",-0.47671,-1.2,0.246,1028,0.558,"dacinostat, trichostatin.a, givinostat, romidepsin, M.344, entinostat, tacedinaline, R306465, vorinostat, PCI.24781, panobinostat, SB.939, JNJ.26481585",0.609064892896621,0.253365801062421,FALSE
+"H358","Pearson.est","histamine receptor antagonist",-0.54955,-1.38,0.126,964,0.58,"cimetidine, lafutidine, nizatidine, astemizole, cyproheptadine, terfenadine, tecastemizole, tiotidine, levocetirizine, zolantidine, chloropyramine",0.899629454882437,0.236572006437063,FALSE
+"H358","Pearson.est","HMGCR inhibitor",0.26008,0.715,0.792,207,1,"lovastatin, pitavastatin",0.101274818410506,0,FALSE
+"H358","Pearson.est","HSP inhibitor",-0.45862,-1.15,0.294,828,0.579,"SNX.5422, SNX.2112, ganetespib, tanespimycin, PU.H71, KW.2478, guanidine, XL888, BIIB021, alvespimycin, NVP.AUY922, VER.49009",0.531652669587843,0.237321436272564,FALSE
+"H358","Pearson.est","JAK inhibitor",-0.37185,-0.92,0.565,1391,0.807,"pacritinib, LY2784544, atiprimod",0.247951552180562,0.0931264652779296,FALSE
+"H358","Pearson.est","KIT inhibitor",-0.30976,-0.765,0.74,1203,0.939,"imatinib, tandutinib, telatinib",0.130768280269024,0.0273344077338891,FALSE
+"H358","Pearson.est","MDM inhibitor",0.69494,1.91,0.011,417,0.4,"AMG.232, idasanutlin, nutlin.3, RITA, serdemetan",1.95860731484178,0.397940008672038,FALSE
+"H358","Pearson.est","MEK inhibitor",-0.37332,-0.923,0.526,1440,0.848,"nobiletin, BIX.02188",0.279014255846261,0.0716041477432862,FALSE
+"H358","Pearson.est","MET inhibitor",-0.69648,-1.74,0.0162,1110,0.46,"NVP.BVU972, LY2801653, AMG458, INC.280",1.79048498545737,0.337242168318426,FALSE
+"H358","Pearson.est","microtubule inhibitor",0.30598,0.841,0.615,1008,1,"vinblastine, cytochalasin.b, estramustine.phosphate, secnidazole, vinflunine, colchicine, D.64131, cabazitaxel, podophyllotoxin, triclabendazole",0.211124884224583,0,FALSE
+"H358","Pearson.est","mTOR inhibitor",0.33804,0.928,0.484,341,1,"SB.2343, torin.1, PF.04691502, AZD2014, PKI.179, WYE.125132, MLN0128, XL388, OSI.027, deforolimus, WYE.354, voxtalisib",0.315154638355588,0,FALSE
+"H358","Pearson.est","NFkB pathway inhibitor",-0.27633,-0.685,0.83,910,0.988,"bindarit, parthenolide, parthenolide...., curcumin, IKK.2.inhibitor.V, Ro.106.9920, bortezomib",0.0809219076239261,0.00524305541237188,FALSE
+"H358","Pearson.est","opioid receptor agonist",-0.68891,-1.71,0.0238,1439,0.384,"salvinorin.a",1.62342304294349,0.415668775632469,FALSE
+"H358","Pearson.est","p38 MAPK inhibitor",-0.54581,-1.36,0.146,847,0.541,"skepinone.l, SB.239063, VX.702, CMPD.1, TAK.715",0.835647144215563,0.266802734893431,FALSE
+"H358","Pearson.est","PARP inhibitor",-0.5201,-1.29,0.189,1042,0.546,"talazoparib, olaparib, PJ.34, niraparib",0.723538195826756,0.262807357295263,FALSE
+"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.21037,-0.526,0.967,1203,1,"imatinib, tandutinib, telatinib, trapidil",0.0145735259169983,0,FALSE
+"H358","Pearson.est","phosphatase inhibitor",0.3071,0.837,0.638,85,1,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.195179321278838,0,FALSE
+"H358","Pearson.est","phosphodiesterase inhibitor",-0.45876,-1.15,0.292,1226,0.579,"zardaverine, YM.976, cilostamide",0.534617148551582,0.237321436272564,FALSE
+"H358","Pearson.est","PI3K inhibitor",0.22834,0.625,0.892,188,1,"ZSTK.474, SB.2343, GDC.0941, idelalisib, PF.04691502, PI.828",0.0496351456238769,0,FALSE
+"H358","Pearson.est","PLK inhibitor",0.44627,1.19,0.262,437,0.687,"NMS.1286937, volasertib, HMN.214, rigosertib",0.581698708680255,0.16304326294045,FALSE
+"H358","Pearson.est","potassium channel blocker",-0.3801,-0.951,0.506,990,0.843,"meglitinide, oleoylethanolamide, dofetilide",0.295849483160201,0.0741724253752577,FALSE
+"H358","Pearson.est","PPAR receptor agonist",0.44704,1.2,0.244,114,0.813,"fenofibrate, pterostilbene",0.612610173661271,0.0899094544059319,FALSE
+"H358","Pearson.est","progesterone receptor agonist",0.50468,1.37,0.146,36,0.617,"tanaproget, norethindrone",0.835647144215563,0.209714835966758,FALSE
+"H358","Pearson.est","proteasome inhibitor",-0.6937,-1.7,0.0203,1115,0.312,"ONX.0914, ixazomib, ixazomib.citrate, bortezomib, carfilzomib",1.69250396208679,0.505845405981557,FALSE
+"H358","Pearson.est","protein synthesis inhibitor",0.21367,0.575,0.929,119,1,"clindamycin.phosphate, clofoctol",0.0319842860063582,0,FALSE
+"H358","Pearson.est","protein tyrosine kinase inhibitor",0.37864,1.01,0.424,97,0.958,"mubritinib, PP.121",0.372634143407267,0.0186344909214556,FALSE
+"H358","Pearson.est","RAF inhibitor",-0.52378,-1.34,0.139,965,0.546,"SB.590885, AZ.628, CEP.32496, GDC.0879, vemurafenib, dabrafenib",0.856985199745905,0.262807357295263,FALSE
+"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.48529,-1.22,0.227,1214,0.572,"apatinib, vandetanib",0.643974142806877,0.242603971206976,FALSE
+"H358","Pearson.est","retinoid receptor agonist",-0.48555,-1.23,0.215,1328,0.579,"AM.580, tamibarotene, CD.437",0.667561540084395,0.237321436272564,FALSE
+"H358","Pearson.est","ribonucleotide reductase inhibitor",0.25586,0.678,0.83,197,1,"cytarabine, pentostatin, hydroxyurea",0.0809219076239261,0,FALSE
+"H358","Pearson.est","serotonin receptor agonist",0.50283,1.42,0.118,280,0.729,"aripiprazole, NAN.190",0.928117992693875,0.137272471682025,FALSE
+"H358","Pearson.est","serotonin receptor antagonist",-0.36624,-0.921,0.546,1102,0.828,"ziprasidone, lerisetron, SB.228357, sertindole, RS.16566",0.262807357295263,0.0819696632151199,FALSE
+"H358","Pearson.est","sodium channel blocker",0.29604,0.791,0.685,135,1,"oxcarbazepine, benzethonium, A.803467, cibenzoline",0.164309428507574,0,FALSE
+"H358","Pearson.est","src inhibitor",-0.35065,-0.884,0.61,1302,0.83,"PP.2, saracatinib",0.214670164989233,0.0809219076239261,FALSE
+"H358","Pearson.est","sterol demethylase inhibitor",0.45751,1.29,0.201,360,0.696,"sulconazole, posaconazole, chlormidazole, terconazole",0.696803942579511,0.157390760389438,FALSE
+"H358","Pearson.est","TGF beta receptor inhibitor",-0.53326,-1.33,0.173,1240,0.532,"D.4476, repsox, LY2109761",0.761953896871205,0.274088367704952,FALSE
+"H358","Pearson.est","thymidylate synthase inhibitor",-0.62616,-1.57,0.0686,1046,0.459,"trifluridine, raltitrexed, carmofur, doxifluridine",1.16367588429325,0.338187314462739,FALSE
+"H358","Pearson.est","topoisomerase inhibitor",-0.41908,-1.06,0.377,1251,0.705,"SN.38, camptothecin, irinotecan, licochalcone.a, genz.644282, exatecan.mesylate",0.423658649794207,0.151810883008601,FALSE
+"H358","Pearson.est","tubulin polymerization inhibitor",-0.20919,-0.53,0.974,704,1,"parbendazole, vincristine, docetaxel, nocodazole, flubendazole, albendazole, indibulin, plinabulin, oxibendazole, epothilone.b, taltobulin, vinorelbine, podophyllotoxin, KX2.391, paclitaxel, fosbretabulin, epothilone.d, combretastatin.A.4",0.0114410431213845,0,FALSE
+"H358","Pearson.est","tyrosine kinase inhibitor",-0.27884,-0.692,0.818,1058,1,"rheochrysidin, BMS.599626, CP.724714, tyrphostin.A9, apatinib, vandetanib, AV.412, tivantinib, AMG.208",0.087246696328677,0,FALSE
+"H358","Pearson.est","VEGFR inhibitor",-0.20129,-0.496,0.988,1157,0.998,"lucitanib, AEE788, BMS.690514, vandetanib, golvatinib, telatinib, MGCD.265",0.00524305541237188,0.000869458712628891,FALSE
+"H358","Pearson.est","vitamin D receptor agonist",-0.48833,-1.23,0.227,1230,0.579,"maxacalcitol, ercalcitriol, calcitriol",0.643974142806877,0.237321436272564,FALSE
+"A549","Pearson.est","EGFR inhibitor",0.72123,1.83,0.0139,328,0.365,"pelitinib, tucatinib, dacomitinib, osimertinib, afatinib, CP.724714, AZD8931, canertinib, WZ8040, OSI.420, poziotinib, neratinib, erlotinib, icotinib, vandetanib, gefitinib, ARRY.334543, BMS.599626, BMS.690514, AEE788, AST.1306, rociletinib, PD.168393, CUDC.101, CNX.2006, PD.153035, XL.647, GW.583340, BIBU.1361, salvianolic.acid.B, lapatinib",1.8569851997459,0.437707135543525,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",0.33981,0.878,0.605,198,0.894,"ZM.306416, imatinib, flumatinib",0.218244625347531,0.0486624812040823,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",0.35494,0.931,0.515,71,0.904,"oxiracetam",0.288192770958809,0.0438315695246367,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",0.59753,1.55,0.078,451,0.388,"dicycloverine, darifenacin, diphemanil, hyoscyamine",1.10790539730952,0.411168274405793,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.68202,1.76,0.0199,455,0.389,"CGS.15943, MRS.1220, SCH.58261, PSB.1115, istradefylline, sulmazole",1.70114692359029,0.410050398674292,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",0.35495,0.925,0.512,226,0.885,"oxymetazoline, methyldopa, A61603, isoetharine",0.290730039024169,0.0530567293021746,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",0.299,0.777,0.682,240,0.926,"atenolol...., RS.17053, dronedarone, pindolol, prazosin",0.166215625343521,0.0333890133180656,FALSE
+"A549","Pearson.est","AKT inhibitor",0.41432,1.06,0.366,368,0.797,"CCT128930, uprosertib, palomid.529, GSK2110183, A.674563",0.436518914605589,0.0985416786038876,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.28314,-0.715,0.8,1081,1,"AZD3463, alectinib, lorlatinib, crizotinib",0.0969100130080564,0,FALSE
+"A549","Pearson.est","androgen receptor antagonist",0.62025,1.57,0.0554,514,0.533,"cyproterone.acetate, nilutamide, flutamide, bicalutamide",1.25649023527157,0.273272790973428,FALSE
+"A549","Pearson.est","antioxidant",-0.47403,-1.22,0.22,1062,0.54,"rutin, trolox, chlorogenic.acid, mesna",0.657577319177794,0.267606240177031,FALSE
+"A549","Pearson.est","AP inhibitor",0.65323,1.65,0.0335,232,0.545,"embelin, tanshinone.i, LCL.161",1.47495519296315,0.263603497723358,FALSE
+"A549","Pearson.est","ATPase inhibitor",-0.37192,-0.944,0.519,1258,0.864,"rabeprazole, digitoxigenin, oligomycin.a",0.284832642151542,0.0634862575211067,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.6688,-1.74,0.0245,1129,0.388,"SNS.314, barasertib, KW.2449, MLN.8054, alisertib, tozasertib, CCT137690, danusertib, AT.9283, TAK.901, PF.03814735, hesperadin, MK.8745, MK.5108, GSK1070916, AMG900",1.61083391563547,0.411168274405793,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26181,0.686,0.831,1071,0.927,"tilmicosin, dirithromycin, josamycin, valnemulin, azalomycin.b, azithromycin, radezolid, tedizolid",0.080398976215889,0.0329202658555029,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.61641,-1.57,0.074,1306,0.302,"lomefloxacin, novobiocin, finafloxacin",1.13076828026902,0.519993057042849,FALSE
+"A549","Pearson.est","BCL inhibitor",0.49789,1.31,0.188,272,0.613,"ABT.737, navitoclax, obatoclax",0.72584215073632,0.212539525481585,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.27889,-0.693,0.828,1270,1,"tozasertib, GZD824",0.0819696632151199,0,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",0.26481,0.672,0.849,564,0.925,"temazepam, piperazine, indiplon, CL.218872, gamma.aminobutyric.acid, ZK.93423, eprinomectin, CGS.20625",0.0710923097560473,0.0338582672609674,FALSE
+"A549","Pearson.est","bromodomain inhibitor",-0.33645,-0.848,0.638,1354,0.887,"OTX015",0.195179321278838,0.0520763801682736,FALSE
+"A549","Pearson.est","calcium channel blocker",0.28824,0.737,0.783,394,0.919,"SKF.96365, mibefradil, tetrandrine, efonidipine.monoethanolate, fendiline",0.106238237942057,0.0366844886138887,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",-0.50501,-1.26,0.201,1351,0.511,"UNBS.5162, ZK811752",0.696803942579511,0.291579099865287,FALSE
+"A549","Pearson.est","CDK inhibitor",0.32859,0.839,0.631,69,0.891,"CR8..R., BMS.387032, TG.02, AT.7519, indirubin",0.199970640755866,0.0501222959631252,FALSE
+"A549","Pearson.est","CHK inhibitor",0.48472,1.27,0.171,88,0.656,"PF.477736",0.767003889607846,0.18309616062434,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",-0.21706,-0.546,0.956,1005,0.986,"phenazone, meloxicam, amfenac, aspirin, metoxibutropate, suxibuzone, tepoxalin, curcumin, acetylsalicylsalicylic.acid",0.0195421077238999,0.0061230850587888,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",0.40507,1.02,0.421,196,0.813,"morin, itraconazole",0.375717904164332,0.0899094544059319,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.31491,-0.793,0.701,1167,0.915,"TH.302, mitomycin.c, satraplatin, cyclophosphamide, carboplatin",0.154281982033341,0.0385789059335517,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.56682,-1.44,0.0987,1092,0.415,"oxaliplatin, nimorazole, chlorambucil, sangivamycin, tirapazamine, metronidazole, valrubicin, teroxirone, carboplatin",1.00568284733036,0.381951903287907,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",-0.31782,-0.813,0.678,1255,0.916,"decitabine, disulfiram",0.168770306132937,0.0381045263321496,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",0.26221,0.67,0.841,381,0.907,"menadione, famciclovir, adefovir.dipivoxil, cidofovir",0.0752040042020878,0.0423927129399047,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.40422,-1.03,0.412,1014,0.773,"nelarabine, CB.10.277, azodicarbonamide, altretamine, artemisinin, mitomycin.c, cyclocytidine, floxuridine, artesunate",0.385102783966865,0.111820506081675,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",-0.22396,-0.567,0.946,1114,1,"oxiperomide, amisulpride, raclopride, domperidone, thioproperazine",0.0241088635982073,0,FALSE
+"A549","Pearson.est","estrogen receptor agonist",-0.23853,-0.591,0.926,1050,1,"levonorgestrel, estradiol.cypionate, estrone",0.0333890133180656,0,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.34222,0.902,0.549,66,0.903,"tamoxifen",0.260427655549908,0.0443122496864942,FALSE
+"A549","Pearson.est","FGFR inhibitor",0.60415,1.58,0.063,276,0.612,"orantinib, PD.173074, erdafitinib, lenvatinib, lucitanib",1.20065945054642,0.213248577854439,FALSE
+"A549","Pearson.est","FLT3 inhibitor",0.17547,0.458,0.992,301,0.991,"TG.02, pacritinib, tandutinib, TG.101348",0.00348832784582135,0.00392634551472468,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.25454,-0.647,0.867,1017,1,"prednisolone.hemisuccinate, halobetasol.propionate, beclomethasone.dipropionate, fluocinolone.acetonide, ciclesonide, dexamethasone.acetate, desonide, triamcinolone, prednisolone, fluticasone.propionate",0.0619809025237897,0,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.57282,1.46,0.107,475,0.514,"LY456236, CPP, MTPG, kynurenic.acid, JNJ.16259685, diazooxonorleucine, ACDPP, felbamate, latrepirdine, IEM1754",0.97061622231479,0.289036881004724,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",0.23578,0.594,0.919,69,0.943,"indirubin",0.0366844886138887,0.0254883072626717,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",-0.51857,-1.3,0.195,1081,0.481,"AZD3463, lestaurtinib, danusertib, PHA.848125",0.709965388637482,0.317854923626168,FALSE
+"A549","Pearson.est","HCV inhibitor",0.44975,1.17,0.261,57,0.667,"embelin",0.583359492661719,0.175874166083451,FALSE
+"A549","Pearson.est","HDAC inhibitor",0.27616,0.737,0.797,458,0.919,"pyroxamide, nexturastat.a, SB.939, vorinostat, R306465, M.344, panobinostat, JNJ.26481585, belinostat",0.0985416786038876,0.0366844886138887,FALSE
+"A549","Pearson.est","histamine receptor antagonist",0.56549,1.44,0.093,416,0.495,"chloropyramine, tecastemizole, ICI.162846, tiotidine, epinastine, cimetidine, astemizole, cyproheptadine, levocetirizine, nizatidine, BF2.649, terfenadine",1.03151705144606,0.305394801066431,FALSE
+"A549","Pearson.est","HMGCR inhibitor",-0.68557,-1.72,0.0291,1174,0.299,"fluvastatin, pitavastatin, simvastatin",1.53610701101409,0.52432881167557,FALSE
+"A549","Pearson.est","HSP inhibitor",0.27416,0.703,0.794,302,0.926,"alvespimycin, XL888, KW.2478, guanidine, tanespimycin, VER.49009",0.100179497572904,0.0333890133180656,FALSE
+"A549","Pearson.est","JAK inhibitor",0.27623,0.724,0.775,301,0.917,"TG.02, LY2784544, AZD1480, pacritinib, atiprimod, TG.101348",0.11069829749369,0.0376306643299789,FALSE
+"A549","Pearson.est","KIT inhibitor",0.43561,1.15,0.271,281,0.674,"imatinib, cediranib, motesanib, pazopanib, lenvatinib, tandutinib",0.567030709125594,0.17134010346468,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.60744,-1.6,0.0625,958,0.301,"AMG.232, RITA, nutlin.3, serdemetan, idasanutlin",1.20411998265592,0.521433504406157,FALSE
+"A549","Pearson.est","MEK inhibitor",-0.56026,-1.42,0.112,1228,0.401,"PD.198306, MEK162, trametinib, AZD8330, PD.184352, PD.318088, PD.0325901, PD.98059, Ro.4987655, refametinib",0.950781977329818,0.396855627379818,FALSE
+"A549","Pearson.est","MET inhibitor",-0.37787,-0.96,0.48,905,0.874,"NVP.BVU972, LY2801653, PHA.665752, PF.04217903",0.318758762624413,0.058488567365597,FALSE
+"A549","Pearson.est","microtubule inhibitor",-0.42796,-1.09,0.354,1122,0.694,"vinflunine, cabazitaxel, D.64131, secnidazole, vinblastine",0.450996737974212,0.158640529545145,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.58952,-1.5,0.0827,1084,0.364,"sirolimus, PI.103, voxtalisib, WYE.125132, AZD2014, XL388, GDC.0980, OSI.027, NVP.BEZ235, PF.04691502, MLN0128, PKI.179, LY303511, GSK2126458, torin.1, ku.0063794, PP242, SB.2343",1.08249449044745,0.438898616350944,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",0.37134,0.96,0.499,365,0.909,"parthenolide, Ro.106.9920, tyloxapol, bortezomib, bindarit, IKK.2.inhibitor.V",0.30189945437661,0.0414361167780325,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.33856,-0.864,0.617,1177,0.895,"spiradoline, BW.180C",0.209714835966758,0.048176964684088,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",0.23144,0.598,0.907,453,0.96,"SB.242235, TAK.715, skepinone.l, SB.239063",0.0423927129399047,0.0177287669604316,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.36373,-0.935,0.521,986,0.801,"AZD2461, AG.14361, niraparib, talazoparib, olaparib",0.283162276700476,0.0963674839157623,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.38589,1.04,0.398,313,0.806,"orantinib, imatinib, motesanib, pazopanib, lenvatinib, tandutinib, linifanib",0.400116927926312,0.0936649581949093,FALSE
+"A549","Pearson.est","phosphatase inhibitor",0.30618,0.78,0.707,194,0.946,"BVT.948, menadione, mycophenolate.mofetil",0.150580586203101,0.0241088635982073,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",0.368,0.939,0.513,399,0.919,"cilostamide, anagrelide, avanafil, enoximone",0.289882634888184,0.0366844886138887,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.55838,-1.41,0.133,1052,0.381,"PI3K.IN.2, PIK.75, PI.103, voxtalisib, CH5132799, GDC.0980, NVP.BEZ235, PF.04691502, ZSTK.474, PKI.179, LY303511, GSK2126458, buparlisib, GDC.0941, YM.201636, SB.2343",0.876148359032914,0.419075024324381,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.71681,-1.83,0.0133,1131,0.419,"rigosertib, volasertib, GSK461364, NMS.1286937, HMN.214, GW.843682X",1.87614835903291,0.377785977033705,FALSE
+"A549","Pearson.est","potassium channel blocker",0.34231,0.865,0.608,417,0.892,"dofetilide, oleoylethanolamide, mepivacaine",0.216096420727265,0.0496351456238769,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.45959,1.2,0.251,308,0.644,"S26948, GW.501516, oleoylethanolamide",0.600326278518962,0.191114132640188,FALSE
+"A549","Pearson.est","progesterone receptor agonist",-0.21404,-0.533,0.959,1000,0.964,"nomegestrol.acetate, levonorgestrel, norethindrone, tanaproget",0.0181813928293364,0.0159229660971692,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.30516,0.768,0.732,442,0.918,"carfilzomib, bortezomib, ixazomib.citrate, oprozomib",0.135488918941608,0.0371573187987575,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.36886,-0.937,0.522,1079,0.835,"anguidine, thiostrepton, methacycline, chloramphenicol.palmitate, harringtonine, mercaptopurine, cycloheximide",0.282329496997738,0.0783135245163979,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",0.54388,1.39,0.149,341,0.546,"CP.724714, BMS.599626, AV.412, rheochrysidin",0.826813731587726,0.262807357295263,FALSE
+"A549","Pearson.est","RAF inhibitor",0.53018,1.34,0.161,93,0.599,"dabrafenib, GDC.0879, CEP.32496",0.79317412396815,0.222573177610689,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",0.32054,0.819,0.657,74,0.902,"vandetanib",0.182434630440219,0.0447934624580583,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.46293,1.22,0.226,298,0.637,"adarotene, tamibarotene, fenretinide, CD.437",0.645891560852599,0.19586056766465,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.52984,-1.35,0.164,1012,0.433,"triapine, gemcitabine, fludarabine.phosphate, clofarabine, cladribine, fludarabine, hydroxyurea",0.785156151952302,0.363512103646635,FALSE
+"A549","Pearson.est","serotonin receptor agonist",0.6162,1.56,0.0735,1,0.417,"aripiprazole",1.1337126609158,0.379863945026242,FALSE
+"A549","Pearson.est","serotonin receptor antagonist",0.60926,1.56,0.0655,117,0.417,"aripiprazole, lurasidone, lerisetron",1.18375870000822,0.379863945026242,FALSE
+"A549","Pearson.est","sodium channel blocker",-0.24901,-0.63,0.908,1260,1,"oxcarbazepine, butamben, benzocaine",0.0419141514789149,0,FALSE
+"A549","Pearson.est","src inhibitor",0.49786,1.26,0.209,364,0.634,"ZM.306416, saracatinib, PP.1, TG.100572, PP.2",0.679853713888946,0.197910742118267,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",-0.68318,-1.7,0.0238,1375,0.255,"chlormidazole, lanoconazole",1.62342304294349,0.593459819566045,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",0.77207,1.99,0.00213,177,0.205,"SB.431542, LY2109761, repsox, D.4476",2.67162039656126,0.688246138944246,TRUE
+"A549","Pearson.est","thymidylate synthase inhibitor",0.4285,1.08,0.341,133,0.789,"doxifluridine, capecitabine",0.467245621007502,0.10292299679058,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.64381,-1.6,0.064,1135,0.301,"genz.644282, topotecan, nemorubicin, teniposide, rubitecan, SN.38, etoposide, amonafide, valrubicin, idarubicin, TAS.103, epirubicin, doxorubicin, voreloxin, mitoxantrone, amsacrine",1.19382002601611,0.521433504406157,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",-0.45473,-1.15,0.294,1093,0.62,"KX2.391, taltobulin, fenbendazole, epothilone.b, oxibendazole, vinblastine, mebendazole, verubulin, BNC105",0.531652669587843,0.207608310501746,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",0.34235,0.882,0.581,231,0.914,"CP.724714, vandetanib, hypericin, BMS.599626, tivantinib, AV.412",0.235823867609669,0.0390538042661686,FALSE
+"A549","Pearson.est","VEGFR inhibitor",0.47334,1.23,0.251,277,0.655,"orantinib, ZM.306416, golvatinib, cediranib, PD.173074, vandetanib, motesanib, BMS.690514, AEE788, pazopanib, lenvatinib, XL.647, lucitanib, TG.100572",0.600326278518962,0.183758700008217,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",0.3308,0.847,0.626,386,0.902,"paricalcitol, tacalcitol, alfacalcidol",0.20342566678957,0.0447934624580583,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",-0.36413,-0.96,0.472,1143,0.919,"GW.583340, salvianolic.acid.B, pelitinib, BIBU.1361, PD.153035, XL.647, tyrphostin.AG.1478, icotinib, gefitinib, CNX.2006, BIBX.1382, OSI.420, erlotinib, vandetanib, rociletinib, PD.168393, WZ8040, CGP.52411",0.326058001365912,0.0366844886138887,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",-0.24164,-0.642,0.872,347,0.98,"flumatinib, bafetinib, nilotinib, imatinib, metatinib, KW.2449, GZD824, tozasertib, ZM.306416, ponatinib, bosutinib, dasatinib",0.0594835150674328,0.00877392430750515,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",0.62991,1.57,0.0553,143,0.677,"xanomeline, oxiracetam, tremorine",1.2572748686953,0.169411331314856,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",0.45068,1.14,0.301,762,0.723,"hyoscyamine, dicycloverine, iododexetimide, diphemanil, darifenacin",0.521433504406157,0.140861702705469,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",0.25125,0.643,0.885,473,0.918,"MRS.1220, PSB.1115, sulmazole",0.0530567293021746,0.0371573187987575,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",0.19407,0.495,0.975,286,0.998,"ritodrine, lidamidine, clenbuterol",0.0109953843014632,0.000869458712628891,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",-0.20058,-0.546,0.968,1224,1,"pindolol, levobunolol, metoprolol, imiloxan",0.0141246426916063,0,FALSE
+"HCC15","Pearson.est","AKT inhibitor",-0.33437,-0.902,0.554,1105,0.944,"triciribine, GSK2110183, CCT128930, AT7867",0.25649023527157,0.025028005701931,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.3834,-1.04,0.408,1239,0.992,"GW.788388, alectinib, AP26113, lorlatinib",0.38933983691012,0.00348832784582135,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",0.51074,1.25,0.221,611,0.69,"cyproterone.acetate, nilutamide, bicalutamide, enzalutamide, flutamide",0.655607726314889,0.161150909262745,FALSE
+"HCC15","Pearson.est","antioxidant",-0.57358,-1.57,0.0568,1281,0.544,"rutin, benfotiamine, mesna",1.24565166428898,0.26440110030182,FALSE
+"HCC15","Pearson.est","AP inhibitor",-0.40923,-1.12,0.314,1418,0.854,"embelin",0.503070351926785,0.068542129310995,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",0.55867,1.39,0.124,224,0.803,"k.strophanthidin, evodiamine, NMS.873, digoxin, digitoxin",0.906578314837765,0.095284454721319,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",-0.36737,-1.01,0.392,1108,0.922,"MK.8745, PF.03814735, AT.9283, CCT129202, barasertib.HQPA, TAK.901, GSK1070916, hesperadin, MLN.8054, CYC116",0.406713932979543,0.0352690789463706,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.36783,0.917,0.542,618,0.848,"dirithromycin, josamycin, azithromycin, tedizolid, tilmicosin, azalomycin.b",0.266000713461613,0.0716041477432862,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.3331,0.837,0.672,155,0.852,"norfloxacin, sarafloxacin",0.172630726946175,0.0695604052332999,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.56175,1.39,0.108,578,0.803,"TW.37, oridonin, HA14.1, venetoclax, ABT.737, gossypol",0.96657624451305,0.095284454721319,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.24131,-0.656,0.868,347,1,"flumatinib, bafetinib, nilotinib, imatinib, metatinib, GZD824, tozasertib, ponatinib, bosutinib, dasatinib",0.0614802748235081,0,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.43467,1.09,0.364,389,0.711,"temazepam, ZK.93423, indiplon, bentazepam, piperazine",0.438898616350944,0.148130399270234,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.54202,1.35,0.152,591,0.694,"PFI.1, JQ1...., bromosporine, I.BET151",0.818156412055227,0.158640529545145,FALSE
+"HCC15","Pearson.est","calcium channel blocker",0.51064,1.29,0.174,409,0.686,"fendiline, carboxyamidotriazole, tetrandrine, pranidipine, SKF.96365, efonidipine.monoethanolate",0.7594507517174,0.163675884293248,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.31104,0.774,0.704,580,0.868,"UNBS.5162, SB.225002, ZK811752, PF.04136309, MK.0812",0.152427340857888,0.0614802748235081,FALSE
+"HCC15","Pearson.est","CDK inhibitor",-0.1715,-0.451,0.992,1176,0.992,"R547, aminopurvalanol.a, NU6027, palbociclib, ribociclib",0.00348832784582135,0.00348832784582135,FALSE
+"HCC15","Pearson.est","CHK inhibitor",0.4669,1.16,0.274,533,0.749,"PF.477736, LY2606368, SB.218078, CHIR.124, LY2603618",0.562249437179612,0.125518182300534,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.35169,-0.941,0.532,1115,0.908,"curcumin, acetylsalicylsalicylic.acid, meloxicam, indoprofen, tryptanthrin, amfenac, pterostilbene",0.274088367704952,0.0419141514789149,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",0.41495,1.03,0.432,716,0.752,"itraconazole, eplerenone, morin, metyrapone, PF.4981517",0.364516253185088,0.123782159408358,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",-0.29573,-0.827,0.673,1288,0.916,"streptozotocin, cyclophosphamide, TH.302, dianhydrogalactitol",0.171984935776023,0.0381045263321496,FALSE
+"HCC15","Pearson.est","DNA inhibitor",0.30675,0.777,0.716,487,0.883,"mechlorethamine, valrubicin, teroxirone, metronidazole, sangivamycin, primaquine, melphalan, bendamustine",0.145086977692144,0.0540392964224314,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.4311,1.08,0.387,298,0.704,"SGI.1027, decitabine",0.412289034981089,0.152427340857888,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.43599,1.1,0.343,346,0.719,"trifluridine, idoxuridine, menadione",0.464705879957229,0.143271109617117,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",0.28756,0.712,0.834,403,0.858,"azodicarbonamide, artesunate, floxuridine, mitomycin.c, enocitabine",0.0788339493622613,0.0665127121512946,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",-0.47472,-1.28,0.182,1277,0.586,"clebopride, amisulpride, remoxipride, acetophenazine, oxiperomide",0.739928612014925,0.232102383981909,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.29412,-0.806,0.683,1415,0.916,"PPT",0.165579296318467,0.0381045263321496,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",-0.28641,-0.78,0.709,413,0.924,"danazol, clomifene, toremifene, tamoxifen, raloxifene, fulvestrant",0.149353764816933,0.0343280287798933,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.5912,1.48,0.0759,433,0.843,"regorafenib, dovitinib, erdafitinib, nintedanib, lenvatinib, AZD4547",1.11975822410452,0.0741724253752577,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.39599,0.987,0.47,448,0.812,"dovitinib, sorafenib, GTP.14564, quizartinib, tandutinib, ENMD.2076, TG.101348",0.327902142064283,0.0904439707588247,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.19901,-0.543,0.972,1230,0.994,"hydrocortisone, dexamethasone.acetate, fluorometholone, fluticasone.propionate, prednisolone.acetate",0.0123337350737254,0.00261361560268669,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",-0.29938,-0.829,0.635,1313,0.956,"CPP, latrepirdine, SIB.1757",0.197226274708024,0.0195421077238999,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.28214,-0.762,0.726,406,0.915,"AZD2858, tideglusib, kenpaullone, GSK.3.inhibitor.IX, CHIR.99021, TWS.119, CHIR.98014, indirubin, LY2090314",0.139063379299906,0.0385789059335517,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",0.30353,0.773,0.732,335,0.85,"GSK1838705A, PHA.848125",0.135488918941608,0.0705810742857073,FALSE
+"HCC15","Pearson.est","HCV inhibitor",-0.47363,-1.28,0.191,1391,0.586,"Ro.9187, embelin",0.718966632752272,0.232102383981909,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",-0.35815,-0.994,0.422,1206,0.896,"chidamide, entinostat, romidepsin, tacedinaline, RG2833, mocetinostat, JNJ.26481585",0.374687549038326,0.0476919903378748,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",-0.32487,-0.864,0.596,1300,0.977,"epinastine, levocetirizine, tiotidine, pheniramine",0.224753740259764,0.0101054362812269,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",-0.53583,-1.47,0.0941,1193,0.445,"lovastatin, simvastatin",1.02641037657274,0.351639989019068,FALSE
+"HCC15","Pearson.est","HSP inhibitor",0.54419,1.36,0.123,535,0.813,"SNX.2112, KW.2478, NMS.E973, SNX.5422, ganetespib, XL888, BIIB021, NVP.AUY922, PU.H71, guanidine",0.910094888560602,0.0899094544059319,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.28935,0.723,0.809,191,0.88,"baricitinib, CEP.33779, AZD1480",0.0920514783877277,0.0555173278498314,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.43859,1.1,0.342,376,0.719,"regorafenib, OSI.930, sorafenib, masitinib, pazopanib, tandutinib, lenvatinib, cediranib",0.465973893943865,0.143271109617117,FALSE
+"HCC15","Pearson.est","MDM inhibitor",-0.81327,-2.26,0,1311,0.00618,"CGM097, idasanutlin, AMG.232, RITA",Inf,2.20901152491118,TRUE
+"HCC15","Pearson.est","MEK inhibitor",-0.8304,-2.31,0,1305,0.00618,"PD.98059, U.0126, PD.198306, PD.0325901, PD.318088, MEK162, PD.184352, trametinib, TAK.733, AS.703026, cobimetinib, AZD8330, selumetinib, refametinib, Ro.4987655",Inf,2.20901152491118,TRUE
+"HCC15","Pearson.est","MET inhibitor",-0.55433,-1.54,0.0981,1218,0.403,"INC.280, PHA.665752, PF.04217903",1.00833099262005,0.39469495385889,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.66901,1.66,0.0297,292,0.523,"colchicine, vinblastine, D.64131, vinflunine, podophyllotoxin, cabazitaxel",1.52724355068279,0.281498311132726,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",-0.47917,-1.33,0.175,1043,0.628,"torin.1, MLN0128, GSK2126458, LY3023414, temsirolimus, OSI.027, AZD8055, PF.04691502, NVP.BEZ235, SB.2343, GDC.0980, XL388, PF.05212384, sirolimus, WYE.354",0.756961951313706,0.202040356262804,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.28784,0.722,0.795,203,0.863,"EVP4593, IKK.2.inhibitor.V, tyloxapol",0.0996328713435297,0.0639892042847904,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",0.29931,0.771,0.732,438,0.835,"cebranopadol, trimebutine, spiradoline, salvinorin.a",0.135488918941608,0.0783135245163979,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",-0.24636,-0.679,0.868,355,1,"talmapimod, SB.242235, SB.239063, TAK.715, VX.702, skepinone.l, CMPD.1",0.0614802748235081,0,FALSE
+"HCC15","Pearson.est","PARP inhibitor",-0.3662,-1.01,0.406,1243,0.922,"E7449, endo.IWR.1",0.391473966422806,0.0352690789463706,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.36222,0.901,0.568,345,0.854,"regorafenib, dovitinib, sorafenib, masitinib, pazopanib, nintedanib, tandutinib, lenvatinib, crenolanib",0.245651664288981,0.068542129310995,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.52997,1.33,0.17,346,0.691,"CID.5458317, AS.1949490, GSK2830371, sodium.stibogluconate, menadione",0.769551078621726,0.160521952625802,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",0.35281,0.876,0.619,478,0.853,"avanafil, enoximone, cilostamide, EMD.53998",0.208309350979882,0.069050968832477,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",-0.30464,-0.836,0.66,1067,0.988,"GSK2126458, ZSTK.474, pilaralisib, LY3023414, alpelisib, PF.04691502, GDC.0941, CH5132799, NVP.BEZ235, SB.2343, GDC.0980, PF.05212384",0.180456064458131,0.00524305541237188,FALSE
+"HCC15","Pearson.est","PLK inhibitor",0.78001,2,0.0016,324,0.0944,"volasertib, BI.2536, NMS.1286937, GW.843682X, HMN.214, rigosertib, GSK461364",2.79588001734407,1.02502800570193,TRUE
+"HCC15","Pearson.est","potassium channel blocker",0.40497,1.05,0.382,230,0.738,"ML133, dofetilide",0.417936637088291,0.131943638176958,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.57239,-1.56,0.0669,1223,0.451,"GW.501516, clofibrate, fenofibrate, pterostilbene",1.17457388223218,0.345823458122039,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",0.3415,0.87,0.62,558,0.84,"danazol, norethindrone, norethindrone.acetate, melengestrol.acetate",0.207608310501746,0.0757207139381184,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.38092,0.951,0.507,86,0.832,"MG.132",0.294992040666664,0.0798766737092761,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.52398,1.32,0.159,536,0.663,"puromycin, clofoctol, thiostrepton, homoharringtonine, harringtonine, bruceantin, methacycline, anguidine, chloramphenicol.palmitate, emetine, cycloheximide, tedizolid.phosphate",0.798602875679548,0.178486471595227,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.49482,1.24,0.201,201,0.673,"tyrphostin.A9, PP.121, mubritinib",0.696803942579511,0.171984935776023,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.58151,1.46,0.0912,194,0.776,"regorafenib, SB.590885, RAF265, sorafenib, TAK.632",1.04000516167158,0.110138278741812,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.50405,1.28,0.184,118,0.664,"regorafenib, sorafenib",0.735182176990464,0.177831920631982,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",0.47364,1.21,0.25,4,0.669,"adarotene",0.602059991327962,0.174573882232177,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.32445,0.823,0.677,519,0.833,"fludarabine.phosphate, triapine, LY2334737, cladribine, hydroxyurea, gemcitabine",0.169411331314856,0.0793549985932124,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",0.45896,1.13,0.323,152,0.713,"pardoprunox, zolmitriptan",0.490797477668897,0.146910470148134,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",0.38837,0.979,0.482,453,0.801,"SB.200646, lerisetron, pirenperone, sertindole, tropisetron, lurasidone",0.31695296176115,0.0963674839157623,FALSE
+"HCC15","Pearson.est","sodium channel blocker",0.19282,0.481,0.979,540,0.983,"brivaracetam, triamterene, benzethonium, A.803467, quinidine, ajmaline",0.00921730819686218,0.00744648216786438,FALSE
+"HCC15","Pearson.est","src inhibitor",0.33909,0.84,0.645,232,0.868,"KX2.391, masitinib, TG.100572",0.190440285364732,0.0614802748235081,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",0.35434,0.884,0.601,45,0.862,"chlormidazole",0.22112552799726,0.0644927341752872,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.32934,0.829,0.644,151,0.844,"LY2109761",0.191114132640188,0.073657553374345,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.52616,1.35,0.139,274,0.694,"trifluridine, raltitrexed, ftorafur",0.856985199745905,0.158640529545145,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",0.48646,1.22,0.231,225,0.68,"dexrazoxane, exatecan.mesylate, daunorubicin, epirubicin, topotecan, mitoxantrone, etoposide.phosphate, valrubicin, doxorubicin, SN.38",0.636388020107856,0.167491087293764,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.71873,1.8,0.0161,291,0.284,"vinorelbine, vindesine, taltobulin, vincristine, vinblastine, parbendazole, dolastatin.10, CYT.997, verubulin, BNC105, paclitaxel, KX2.391, fenbendazole, docetaxel, flubendazole, albendazole, oxibendazole, nocodazole, podophyllotoxin, fosbretabulin, ABT.751",1.79317412396815,0.546681659952962,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.44622,1.14,0.312,201,0.723,"tivantinib, regorafenib, tyrphostin.A9, hypericin, sorafenib, GTP.14564, PP.121, mubritinib",0.505845405981557,0.140861702705469,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.37023,0.929,0.541,430,0.85,"regorafenib, RAF265, OSI.930, dovitinib, sorafenib, tivozanib, pazopanib, TG.100572, nintedanib, lenvatinib, cediranib, ENMD.2076, linifanib",0.266802734893431,0.0705810742857073,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",-0.70642,-2.01,0.014,1131,0.0721,"tacalcitol, calcitriol, paricalcitol, maxacalcitol, ercalcitriol, doxercalciferol",1.85387196432176,1.14206473528057,TRUE
+"HCC44","Pearson.est","EGFR inhibitor",0.64323,1.82,0.0456,217,0.178,"tucatinib, CP.724714, AZD8931, GW.583340, dacomitinib, CNX.2006, canertinib, AEE788, poziotinib, neratinib, pelitinib, afatinib, ARRY.334543, BIBX.1382, BMS.690514, WZ8040, osimertinib, gefitinib, salvianolic.acid.B, PD.153035, OSI.420, vandetanib",1.34103515733556,0.749579997691106,TRUE
+"HCC44","Pearson.est","Abl kinase inhibitor",-0.58323,-1.45,0.0879,1419,0.405,"tozasertib, KW.2449, GZD824",1.05601112492623,0.392544976785331,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",-0.40719,-0.993,0.47,1175,0.935,"tremorine, nicotine",0.327902142064283,0.0291883891274822,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",0.85345,2.46,0,175,0.000534,"diphemanil, dicycloverine, iododexetimide, darifenacin",Inf,3.27245874297144,TRUE
+"HCC44","Pearson.est","adenosine receptor antagonist",0.58032,1.6,0.0602,108,0.34,"CGS.15943, istradefylline, MRS.1220",1.22040350874218,0.468521082957745,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.31782,-0.779,0.728,1038,0.982,"terbutaline, clenbuterol, norepinephrine, metaraminol, buphenine, epinephrine",0.137868620686963,0.00788851221305034,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",0.35319,0.983,0.447,136,0.802,"RS.17053, prazosin, atenolol......, atenolol....",0.349692476868064,0.0958256317158365,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.31028,-0.749,0.781,1118,0.962,"ONC201, triciribine, GDC.0068",0.1073489661227,0.0168249279621871,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27038,-0.677,0.844,1304,0.956,"alectinib, crizotinib",0.073657553374345,0.0195421077238999,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",-0.37646,-0.928,0.552,758,0.96,"flutamide, bicalutamide",0.258060922270801,0.0177287669604316,FALSE
+"HCC44","Pearson.est","antioxidant",-0.73348,-1.8,0.0087,1294,0.122,"chlorogenic.acid, mesna",2.06048074738138,0.913640169325252,TRUE
+"HCC44","Pearson.est","AP inhibitor",0.34876,0.977,0.47,219,0.719,"embelin, tanshinone.i",0.327902142064283,0.143271109617117,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",0.34749,0.943,0.471,74,0.742,"k.strophanthidin, blebbistatin....",0.326979092871104,0.129596094720973,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.74241,-1.82,0.0118,1270,0.137,"MLN.8054, danusertib, AT.9283, GSK1070916, barasertib, CCT137690, MK.8745, alisertib, SNS.314, tozasertib, MK.5108, KW.2449, AMG900, PF.03814735, hesperadin",1.92811799269387,0.863279432843593,TRUE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.33871,-0.828,0.67,1046,0.991,"josamycin, tedizolid",0.173925197299174,0.00392634551472468,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.73557,-1.86,0.00999,1348,0.138,"lomefloxacin, finafloxacin, novobiocin",2.00043451177402,0.860120913598763,TRUE
+"HCC44","Pearson.est","BCL inhibitor",0.20903,0.579,0.954,1147,0.944,"ABT.737, obatoclax, gossypol, navitoclax, venetoclax, HA14.1, oridonin, TW.37",0.0204516252959049,0.025028005701931,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.55903,-1.39,0.116,1419,0.437,"tozasertib, GZD824",0.935542010773082,0.359518563029578,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",0.38778,1.1,0.295,126,0.783,"indiplon, temazepam, nefiracetam",0.530177984021837,0.106238237942057,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",-0.60991,-1.51,0.0717,897,0.325,"bromosporine, PFI.1, JQ1...., OTX015, I.BET.762",1.1444808443322,0.488116639021126,FALSE
+"HCC44","Pearson.est","calcium channel blocker",0.46806,1.3,0.152,401,0.576,"tetrandrine, fendiline, efonidipine.monoethanolate, mibefradil, SR.33805, SKF.96365, pranidipine",0.818156412055227,0.239577516576788,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.53902,-1.33,0.16,865,0.504,"MK.0812, RS.504393, navarixin, SB.225002, ZK811752, UNBS.5162",0.795880017344075,0.297569463554475,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.39735,-0.973,0.495,1122,0.95,"aminopurvalanol.a, palbociclib, indisulam, alvocidib, BMS.265246, PHA.848125, PHA.793887, abemaciclib, AZD5438, R547",0.305394801066431,0.0222763947111523,FALSE
+"HCC44","Pearson.est","CHK inhibitor",0.30743,0.831,0.64,1005,0.723,"PF.477736, CHIR.124, AZD7762, SCH.900776, LY2603618, SB.218078, LY2606368",0.193820026016113,0.140861702705469,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.26235,-0.648,0.879,959,0.932,"piroxicam, phenazone, indoprofen, ketoprofen, acetylsalicylsalicylic.acid, sulfasalazine, curcumin, meloxicam, ramifenazone, aspirin, suxibuzone",0.0560111249262281,0.0305840876460186,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.38228,-0.95,0.533,1110,0.972,"eplerenone, PF.4981517, cobicistat, clotrimazole",0.273272790973428,0.0123337350737254,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",-0.43285,-1.07,0.377,925,0.786,"satraplatin, dianhydrogalactitol, melphalan, mitomycin.c, carmustine, cyclophosphamide, TH.302, carboplatin",0.423658649794207,0.104577453960592,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.5732,-1.41,0.106,974,0.425,"sangivamycin, metronidazole, melphalan, nimorazole, carmustine, tirapazamine, chlorambucil, teroxirone, valrubicin, carboplatin",0.97469413473523,0.371611069949688,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.51204,-1.25,0.217,1221,0.59,"fdcyd, decitabine",0.66354026615147,0.229147988357856,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.31294,-0.773,0.752,1155,0.969,"idoxuridine, foscarnet, trifluridine",0.123782159408358,0.0136762229492347,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",-0.37408,-0.921,0.555,1140,0.945,"mitomycin.c, CB.10.277, cyclocytidine, floxuridine",0.255707016877324,0.0245681914907371,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.21005,-0.515,0.973,887,0.99,"ziprasidone, piperacetazine, domperidone, acetophenazine, UH.232...., isofloxythepin, oxiperomide, thioproperazine",0.0118871597316481,0.00436480540245009,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",-0.45378,-1.14,0.301,916,0.719,"ethinyl.estradiol, PPT, estrone, estradiol, estradiol.cypionate",0.521433504406157,0.143271109617117,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",0.52762,1.51,0.0962,35,0.387,"tamoxifen",1.01682492796219,0.412289034981089,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",0.52348,1.45,0.108,90,0.405,"orantinib, lenvatinib, PD.173074",0.96657624451305,0.392544976785331,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.31902,-0.794,0.707,1138,1,"ENMD.2076, tandutinib, gilteritinib, tozasertib, KW.2449",0.150580586203101,0,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",0.36885,1.04,0.388,329,0.854,"triamcinolone.acetonide, hydrocortisone, deflazacort, flumethasone.pivalate, dexamethasone.acetate, piretanide, halcinonide, betamethasone, rimexolone, prednisolone.hemisuccinate",0.411168274405793,0.068542129310995,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",0.36542,1.02,0.396,325,0.834,"CGP.37849, MTPG, LY456236, CPP, kynurenic.acid",0.402304814074488,0.0788339493622613,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.3363,-0.819,0.684,909,0.984,"LY2090314, kenpaullone, CHIR.99021, tideglusib",0.164943898279884,0.00700490156865849,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.6127,-1.52,0.0725,1256,0.339,"PHA.848125, danusertib, GSK1838705A",1.13966199342901,0.469800301796918,FALSE
+"HCC44","Pearson.est","HCV inhibitor",0.42602,1.18,0.249,144,0.748,"PSI.7976, embelin",0.603800652904264,0.126098402135539,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",-0.2267,-0.558,0.955,715,0.987,"M.344, mocetinostat, resminostat, romidepsin, tacedinaline, PCI.24781, RG2833, panobinostat, chidamide, AR.42, dacinostat, NSC.3852, entinostat, R306465, givinostat, trichostatin.a",0.0199966284162537,0.00568284733036327,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",0.29831,0.832,0.63,335,0.753,"tecastemizole, chloropyramine, epinastine, ebastine, levocetirizine, famotidine, astemizole",0.200659450546418,0.123205023799299,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",-0.36093,-0.874,0.603,976,0.984,"pitavastatin, fluvastatin, simvastatin",0.219682687859849,0.00700490156865849,FALSE
+"HCC44","Pearson.est","HSP inhibitor",-0.45021,-1.12,0.326,1311,0.733,"SNX.2112, ganetespib, NVP.AUY922, BIIB021",0.486782399932061,0.134896025358872,FALSE
+"HCC44","Pearson.est","JAK inhibitor",-0.28813,-0.706,0.811,1223,0.939,"baricitinib, AT.9283, tozasertib, WHI.P154",0.090979145788844,0.0273344077338891,FALSE
+"HCC44","Pearson.est","KIT inhibitor",0.24595,0.678,0.857,190,0.918,"cediranib, lenvatinib, telatinib, motesanib",0.0670191780768018,0.0371573187987575,FALSE
+"HCC44","Pearson.est","MDM inhibitor",-0.5871,-1.44,0.0937,1015,0.395,"serdemetan, CGM097, nutlin.3, idasanutlin",1.02826040911222,0.40340290437354,FALSE
+"HCC44","Pearson.est","MEK inhibitor",-0.65731,-1.62,0.0386,1171,0.265,"PD.318088, PD.184352, PD.198306, MEK162, AS.703026, AZD8330, TAK.733, PD.98059, PD.0325901, cobimetinib, trametinib, Ro.4987655, refametinib",1.41341269532825,0.576754126063192,FALSE
+"HCC44","Pearson.est","MET inhibitor",-0.66182,-1.6,0.0328,1306,0.263,"PHA.665752, LY2801653, PF.04217903",1.48412615628832,0.580044251510242,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",-0.3644,-0.903,0.601,952,0.954,"cytochalasin.b, cabazitaxel, secnidazole, vinflunine, D.64131, vinblastine",0.22112552799726,0.0204516252959049,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",-0.29421,-0.719,0.822,982,0.962,"GDC.0980, LY3023414, PI.103, AZD2014, GSK2126458, MLN0128, PP242, LY303511, ku.0063794, NVP.BEZ235",0.0851281824599496,0.0168249279621871,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",0.35527,0.997,0.462,317,0.825,"tyloxapol, parthenolide, IKK.2.inhibitor.V, parthenolide...., bindarit",0.335358024443874,0.0835460514500749,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.71455,-1.77,0.0115,1161,0.127,"trimebutine, spiradoline, BW.180C",1.93930215964639,0.896196279044043,TRUE
+"HCC44","Pearson.est","p38 MAPK inhibitor",-0.47101,-1.18,0.274,1085,0.657,"talmapimod, VX.702, CMPD.1",0.562249437179612,0.182434630440219,FALSE
+"HCC44","Pearson.est","PARP inhibitor",-0.5632,-1.38,0.126,1319,0.428,"niraparib, talazoparib, olaparib",0.899629454882437,0.368556230986828,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.23321,0.649,0.901,190,0.915,"orantinib, lenvatinib, telatinib, motesanib",0.045275209020937,0.0385789059335517,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",0.33348,0.933,0.497,314,0.72,"mycophenolate.mofetil, menadione, GSK2830371, BVT.948",0.303643611266668,0.142667503568732,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.15848,-0.395,0.996,1309,0.997,"EMD.53998",0.00174066157630127,0.00130484168834428,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",-0.355,-0.861,0.644,972,0.983,"CH5132799, GDC.0980, LY3023414, buparlisib, alpelisib, PI.103, PIK.75, GDC.0941, TG.100713, GSK2126458, LY303511, NVP.BEZ235",0.191114132640188,0.00744648216786438,FALSE
+"HCC44","Pearson.est","PLK inhibitor",-0.70694,-1.76,0.0114,1226,0.114,"HMN.214, GSK461364, BI.2536, volasertib, GW.843682X",1.94309514866353,0.943095148663527,TRUE
+"HCC44","Pearson.est","potassium channel blocker",-0.34117,-0.844,0.655,1336,0.988,"meglitinide",0.183758700008217,0.00524305541237188,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",0.67702,1.9,0.0127,105,0.16,"S26948, GW.501516, pterostilbene",1.89619627904404,0.795880017344075,TRUE
+"HCC44","Pearson.est","progesterone receptor agonist",0.31302,0.863,0.577,266,0.734,"norethindrone.acetate, levonorgestrel, norgestrel, norethindrone",0.238824186844269,0.134303940083929,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",-0.2669,-0.654,0.887,1072,0.944,"bortezomib, ixazomib",0.0520763801682736,0.025028005701931,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",-0.29408,-0.724,0.766,1370,0.976,"cycloheximide, mercaptopurine",0.115771230367396,0.0105501823333082,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.35373,0.977,0.442,324,0.719,"CP.724714, PP.121, AV.412, rheochrysidin",0.354577730650908,0.143271109617117,FALSE
+"HCC44","Pearson.est","RAF inhibitor",-0.28573,-0.714,0.81,924,0.948,"SB.590885, vemurafenib, dabrafenib, RAF265, LGX818",0.0915149811213502,0.0231916626619338,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.5007,-1.25,0.234,1375,0.59,"cabozantinib",0.630784142589857,0.229147988357856,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",-0.4342,-1.07,0.382,1190,0.786,"tamibarotene, AM.580, adapalene",0.417936637088291,0.104577453960592,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.53561,-1.31,0.168,1225,0.517,"triapine, hydroxyurea, fludarabine, fludarabine.phosphate, clofarabine",0.774690718274137,0.286509456906058,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.31635,-0.78,0.753,1328,1,"SR.57227A",0.123205023799299,0,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.37937,-0.943,0.552,1141,0.957,"SB.216641, pirenperone, RS.16566, SB.200646",0.258060922270801,0.0190880622231565,FALSE
+"HCC44","Pearson.est","sodium channel blocker",-0.26716,-0.667,0.864,1083,0.948,"benzocaine, ajmaline, butamben",0.0634862575211067,0.0231916626619338,FALSE
+"HCC44","Pearson.est","src inhibitor",0.31506,0.863,0.614,336,0.734,"ZM.306416, saracatinib, PP.1, TG.100572",0.211831628858832,0.134303940083929,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",-0.62775,-1.56,0.0442,1342,0.299,"lanoconazole, chlormidazole",1.35457773065091,0.52432881167557,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",0.90858,2.48,0,119,0,"SB.431542, SB.525334, repsox, LY2109761, adaprev",Inf,Inf,TRUE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.49448,-1.21,0.258,1197,0.62,"ftorafur, trifluridine, raltitrexed",0.58838029403677,0.207608310501746,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",-0.79345,-1.95,0,1276,0.101,"irinotecan, doxorubicin, camptothecin, teniposide, nemorubicin, amonafide, topotecan, valrubicin, SN.38, etoposide, mitoxantrone, TAS.103, exatecan.mesylate, rubitecan, idarubicin, genz.644282, voreloxin, amsacrine",Inf,0.995678626217357,TRUE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.49754,-1.24,0.212,1186,0.582,"mebendazole, oxibendazole, paclitaxel, fosbretabulin, docetaxel, vinblastine, verubulin, fenbendazole, BNC105, epothilone.b",0.673664139071249,0.235077015350112,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.31221,-0.759,0.779,1044,0.968,"dasatinib, tyrphostin.AG.99, aminopurvalanol.a, UNC2250, bafetinib, NVP.TAE226, cabozantinib, AMG.208",0.108462542327436,0.0141246426916063,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",0.31684,0.877,0.537,217,0.78,"orantinib, cediranib, AEE788, lenvatinib, ZM.306416, PD.173074, BMS.690514, semaxanib, telatinib, motesanib, vandetanib",0.270025714300444,0.10790539730952,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",0.41248,1.14,0.297,299,0.76,"paricalcitol, maxacalcitol, alfacalcidol, tacalcitol",0.527243550682788,0.119186407719209,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.68763,1.72,0.026,223,0.534,"erlotinib, WZ8040, osimertinib, OSI.420, pelitinib, PD.168393, BIBU.1361, canertinib, icotinib, CP.724714, afatinib, BMS.690514, dacomitinib, gefitinib, rociletinib, vandetanib, XL.647, AZD8931, ARRY.334543, tyrphostin.AG.1478, BIBX.1382, AEE788, PD.153035, poziotinib, CNX.2006",1.58502665202918,0.272458742971444,FALSE
+"H1299","Pearson.est","Abl kinase inhibitor",0.18657,0.46,0.993,524,0.991,"ZM.306416, imatinib, bosutinib, metatinib, KW.2449",0.00305075150461883,0.00392634551472468,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.41687,-1.09,0.33,1333,0.73,"nicotine, xanomeline",0.481486060122112,0.136677139879544,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",-0.26832,-0.697,0.824,1079,0.898,"iododexetimide, methscopolamine, hyoscyamine",0.0840727883028842,0.0467236633326956,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",0.84642,2.09,0,166,0.0301,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",Inf,1.52143350440616,TRUE
+"H1299","Pearson.est","adrenergic receptor agonist",0.37973,0.957,0.484,215,0.815,"oxymetazoline, A61603, isoetharine",0.315154638355588,0.0888423912600234,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",0.23303,0.575,0.961,121,1,"atenolol...., RS.17053, dronedarone",0.0172766123314547,0,FALSE
+"H1299","Pearson.est","AKT inhibitor",0.5506,1.37,0.141,461,0.535,"CCT128930, palomid.529, GSK2110183, AZD5363, A.674563, uprosertib",0.85078088734462,0.271646217978772,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.40573,1.01,0.434,385,0.8,"NVP.TAE684, GW.788388, SB.505124, AZD3463, alectinib, AP26113",0.362510270487489,0.0969100130080564,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",-0.32639,-0.856,0.605,1022,0.906,"nilutamide, RU.58841, enzalutamide",0.218244625347531,0.0428718023231869,FALSE
+"H1299","Pearson.est","antioxidant",0.2349,0.576,0.931,350,1,"benfotiamine, taurine",0.0310503190186574,0,FALSE
+"H1299","Pearson.est","AP inhibitor",0.38154,0.925,0.545,480,0.849,"embelin, birinapant, LCL.161, tanshinone.i",0.263603497723358,0.0710923097560473,FALSE
+"H1299","Pearson.est","ATPase inhibitor",-0.76663,-1.99,0.0049,1312,0.189,"rabeprazole, digitoxigenin, evodiamine, thonzonium, digoxin, oligomycin.a, k.strophanthidin",2.30980391997149,0.723538195826756,TRUE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.51823,-1.34,0.167,1078,0.831,"hesperadin, tozasertib, GSK1070916, barasertib, ENMD.2076, SNS.314, CCT137690, TAK.901, MK.5108, AT.9283, AMG900, aurora.a.inhibitor.i",0.777283528852417,0.080398976215889,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40693,-1.07,0.332,1171,0.73,"valnemulin, josamycin",0.478861916295964,0.136677139879544,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.4439,-1.19,0.215,1121,0.626,"nadifloxacin, norfloxacin, lomefloxacin",0.667561540084395,0.20342566678957,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.35184,-0.906,0.558,940,0.919,"obatoclax, venetoclax, TW.37, ABT.737, gossypol",0.253365801062421,0.0366844886138887,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.28902,-0.761,0.749,1086,0.883,"tozasertib, ponatinib, GZD824",0.125518182300534,0.0540392964224314,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.49785,1.23,0.243,348,0.528,"lorazepam, nefiracetam, gamma.aminobutyric.acid, CGS.20625, piperazine, zaleplon",0.614393726401688,0.277366077466188,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",0.53208,1.35,0.159,467,0.532,"JQ1...., I.BET151",0.798602875679548,0.274088367704952,FALSE
+"H1299","Pearson.est","calcium channel blocker",0.24787,0.618,0.918,568,1,"cinnarazine, SR.33805, fendiline, pranidipine, mibefradil, efonidipine.monoethanolate",0.0371573187987575,0,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.48089,-1.28,0.18,1345,0.787,"ZK811752, SB.225002, UNBS.5162",0.744727494896694,0.104025267640935,FALSE
+"H1299","Pearson.est","CDK inhibitor",0.22838,0.562,0.942,177,1,"arcyriaflavin.a, indirubin, BMS.387032",0.0259490972071227,0,FALSE
+"H1299","Pearson.est","CHK inhibitor",0.27134,0.681,0.849,1057,1,"LY2603618, CHIR.124, AZD7762, SCH.900776, SB.218078, LY2606368, PF.477736",0.0710923097560473,0,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",0.36488,0.909,0.531,430,0.85,"tryptanthrin, FR.122047, indoprofen, phenylbutazone, FK.3311, pterostilbene, suxibuzone, ramifenazone, AM.404, metoxibutropate, ketoprofen, meloxicam",0.274905478918531,0.0705810742857073,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",0.51842,1.33,0.172,238,0.464,"morin, PF.4981517, itraconazole",0.764471553092451,0.333482019445119,FALSE
+"H1299","Pearson.est","DNA alkylating agent",0.2981,0.733,0.777,226,1,"ifosfamide, streptozotocin, dacarbazine, TH.302",0.109578981199086,0,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.48524,-1.25,0.228,1137,0.709,"valrubicin, tirapazamine, mechlorethamine, chlorambucil, carboplatin, carmustine, sangivamycin, metronidazole",0.642065152999546,0.149353764816933,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",0.53699,1.33,0.163,410,0.464,"azacitidine, RG108, SGI.1027, fdcyd",0.787812395596042,0.333482019445119,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",-0.51409,-1.34,0.155,1363,0.831,"trifluridine, foscarnet",0.809668301829709,0.080398976215889,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",0.20596,0.525,0.966,593,1,"estramustine.phosphate, capecitabine, floxuridine, altretamine, enocitabine, artemisinin, cisplatin",0.0150228735845067,0,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",-0.22816,-0.584,0.938,1252,0.936,"clebopride, domperidone, thioproperazine",0.0277971616209356,0.0287241512618947,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",-0.39932,-1.02,0.408,1047,0.793,"ethinyl.estradiol, equol, estrone, levonorgestrel",0.38933983691012,0.100726812682396,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.3835,-1.01,0.433,1387,0.773,"toremifene",0.363512103646635,0.111820506081675,FALSE
+"H1299","Pearson.est","FGFR inhibitor",0.39361,0.981,0.452,19,0.797,"PD.173074, orantinib",0.344861565188618,0.0985416786038876,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.31966,-0.821,0.652,1086,0.939,"tozasertib, TG.101348, ponatinib, ENMD.2076, sorafenib, dovitinib, tyrphostin.AG.1296",0.18575240426808,0.0273344077338891,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",0.40959,1.02,0.452,491,0.812,"betamethasone, rimexolone, flumethasone, fludroxycortide, clobetasol.propionate, triamcinolone.acetonide, prednisolone.hemisuccinate, prednisolone.acetate, flumethasone.pivalate, deflazacort, fluocinolone.acetonide, halcinonide, ciclesonide, methylprednisolone",0.344861565188618,0.0904439707588247,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.4723,1.15,0.312,583,0.615,"latrepirdine, MTPG, SIB.1757, kynurenic.acid, CPP, LY456236, ACDPP, JNJ.16259685, diazooxonorleucine, felbamate",0.505845405981557,0.211124884224583,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.56549,1.38,0.125,302,0.56,"LY2090314, indirubin, GSK.3.inhibitor.IX, CHIR.99021, kenpaullone",0.903089986991944,0.2518119729938,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",0.36105,0.893,0.585,436,0.826,"GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.23284413391782,0.0830199526796178,FALSE
+"H1299","Pearson.est","HCV inhibitor",0.53087,1.33,0.173,411,0.464,"Ro.9187, embelin, daclatasvir, PSI.7976",0.761953896871205,0.333482019445119,FALSE
+"H1299","Pearson.est","HDAC inhibitor",0.63048,1.54,0.065,464,0.431,"nexturastat.a, JNJ.26481585, tacedinaline, romidepsin, R306465, SB.939, panobinostat, pyroxamide, RG2833, entinostat, PCI.24781, M.344, vorinostat, resminostat, RGFP966, chidamide",1.18708664335714,0.365522729839268,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",0.56096,1.39,0.127,454,0.592,"terfenadine, levocetirizine, tecastemizole, astemizole, zolantidine, epinastine, cyproheptadine, ICI.162846, ebastine, ranitidine, tiotidine, BF2.649, pheniramine",0.896196279044043,0.22767829327708,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",-0.49338,-1.29,0.207,1060,0.858,"fluvastatin, atorvastatin, lovastatin",0.684029654543082,0.0665127121512946,FALSE
+"H1299","Pearson.est","HSP inhibitor",0.3278,0.802,0.674,383,0.911,"alvespimycin, tanespimycin, SNX.5422, VER.49009, XL888",0.17134010346468,0.0404816230270017,FALSE
+"H1299","Pearson.est","JAK inhibitor",0.19503,0.497,0.977,412,1,"pacritinib, LY2784544, atiprimod, TG.02, PRT062070",0.0101054362812269,0,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.31933,-0.819,0.653,1228,0.908,"regorafenib, pazopanib, sorafenib, lenvatinib",0.185086818724926,0.0419141514789149,FALSE
+"H1299","Pearson.est","MDM inhibitor",0.67602,1.68,0.0385,333,0.462,"CGM097, RITA, serdemetan, nutlin.3",1.4145392704915,0.335358024443874,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.34066,0.851,0.623,153,0.85,"nobiletin, BIX.02188, arctigenin",0.20551195334083,0.0705810742857073,FALSE
+"H1299","Pearson.est","MET inhibitor",-0.60713,-1.62,0.0573,1430,0.506,"LY2801653",1.24184537803261,0.295849483160201,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.37948,-0.998,0.443,1089,0.761,"cabazitaxel, D.64131, vinflunine, vinblastine, secnidazole",0.35359627377693,0.118615343229427,FALSE
+"H1299","Pearson.est","mTOR inhibitor",-0.28756,-0.73,0.797,1143,0.878,"torin.1, voxtalisib, MLN0128, AZD2014, OSI.027, PKI.179, SB.2343, ku.0063794, PF.04691502",0.0985416786038876,0.0565054840938974,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.26027,-0.685,0.821,1427,0.887,"EVP4593",0.0856568428805592,0.0520763801682736,FALSE
+"H1299","Pearson.est","opioid receptor agonist",-0.31462,-0.805,0.679,1382,0.899,"trimebutine",0.168130225719498,0.0462403082667712,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",0.43498,1.07,0.362,465,0.741,"SB.239063, SB.242235, VX.702, skepinone.l",0.441291429466834,0.130181792020672,FALSE
+"H1299","Pearson.est","PARP inhibitor",0.58629,1.46,0.111,570,0.547,"endo.IWR.1, PJ.34, AG.14361, E7449, AZD2461, niraparib, talazoparib",0.954677021213343,0.262012673666569,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30355,-0.789,0.707,1228,0.867,"regorafenib, pazopanib, sorafenib, lenvatinib, linifanib, dovitinib, nintedanib",0.150580586203101,0.0619809025237897,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.33363,-0.865,0.632,1225,0.926,"GSK2830371, bis.maltolato.oxovanadium.IV., alexidine",0.199282921717615,0.0333890133180656,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",0.66011,1.64,0.0452,340,0.357,"GSK256066, papaverine, cilostamide, zardaverine, YM.976, anagrelide, trequinsin",1.34486156518862,0.447331783887807,FALSE
+"H1299","Pearson.est","PI3K inhibitor",-0.30552,-0.79,0.709,1290,0.895,"PKI.179, SB.2343, PF.04691502, buparlisib, GDC.0941",0.149353764816933,0.048176964684088,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.69674,-1.83,0.0147,1004,0.304,"GSK461364, BI.2536, HMN.214, rigosertib, NMS.1286937, volasertib, GW.843682X",1.83268266525182,0.517126416391246,FALSE
+"H1299","Pearson.est","potassium channel blocker",0.52291,1.31,0.18,99,0.422,"oleoylethanolamide",0.744727494896694,0.374687549038326,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",0.51912,1.31,0.174,291,0.422,"S26948, oleoylethanolamide, ciprofibrate, pterostilbene",0.7594507517174,0.374687549038326,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.46786,-1.19,0.231,1262,0.626,"norethindrone, levonorgestrel, tanaproget, nomegestrol.acetate",0.636388020107856,0.20342566678957,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.22566,-0.587,0.926,1210,0.96,"delanzomib, MG.132",0.0333890133180656,0.0177287669604316,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.41597,-1.1,0.329,1216,0.754,"bruceantin, mercaptopurine, anguidine, harringtonine, cycloheximide, chloramphenicol.palmitate, clofoctol",0.482804102050026,0.122628654130226,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.35673,0.906,0.545,181,0.828,"CP.724714, NVP.TAE226",0.263603497723358,0.0819696632151199,FALSE
+"H1299","Pearson.est","RAF inhibitor",0.35669,0.892,0.591,301,0.803,"GDC.0879, CEP.32496, LGX818, dabrafenib",0.228412519118745,0.095284454721319,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.34836,-0.887,0.558,1211,0.919,"cabozantinib, regorafenib, sorafenib",0.253365801062421,0.0366844886138887,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",-0.48439,-1.26,0.204,1425,0.755,"adapalene, fenretinide",0.690369832574101,0.122053048370812,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.44675,-1.2,0.236,1003,0.7,"fludarabine.phosphate, cladribine, triapine, hydroxyurea, pentostatin",0.627087997029893,0.154901959985743,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",0.66616,1.65,0.0298,26,0.417,"ipsapirone, aripiprazole",1.52578373592374,0.379863945026242,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",0.52829,1.32,0.154,96,0.454,"aripiprazole, SB.228357, ziprasidone",0.812479279163537,0.342944147142896,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.29217,-0.759,0.74,1305,0.859,"oxcarbazepine, cibenzoline, benzocaine",0.130768280269024,0.0660068361687577,FALSE
+"H1299","Pearson.est","src inhibitor",0.63064,1.55,0.0568,222,0.479,"saracatinib, PP.2, ZM.306416, PP.1",1.24565166428898,0.319664486585437,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.67554,-1.71,0.0201,1231,0.437,"lanoconazole, posaconazole, sulconazole, chlormidazole",1.69680394257951,0.359518563029578,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",0.57581,1.42,0.122,216,0.577,"LY2109761, D.4476, repsox",0.913640169325252,0.238824186844269,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",0.39961,0.991,0.451,330,0.807,"doxifluridine, capecitabine, carmofur, raltitrexed",0.345823458122039,0.0931264652779296,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.54145,-1.41,0.135,1265,0.922,"amsacrine, idarubicin, TAS.103, voreloxin, topotecan, SN.38, epirubicin, dexrazoxane, etoposide.phosphate, doxorubicin, mitoxantrone",0.869666231504994,0.0352690789463706,FALSE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.46268,-1.22,0.233,1154,0.714,"epothilone.b, verubulin, mebendazole, docetaxel, oxibendazole, vinblastine, BNC105, paclitaxel, vindesine, fenbendazole",0.632644078973981,0.146301788223826,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",0.23223,0.594,0.921,261,1,"CP.724714, vandetanib, NVP.TAE226, apatinib",0.0357403698031511,0,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",0.29058,0.728,0.811,204,0.98,"PD.173074, orantinib, BMS.690514, vandetanib, XL.647, ZM.306416, AEE788, vatalanib",0.090979145788844,0.00877392430750515,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.48464,1.19,0.264,423,0.572,"maxacalcitol, ercalcitriol, tacalcitol, calcitriol",0.578396073130169,0.242603971206976,FALSE
+"H1703","Pearson.est","EGFR inhibitor",0.38864,0.955,0.503,353,0.884,"WZ8040, erlotinib, BIBU.1361, icotinib, TAK.285, pelitinib, tyrphostin.AG.1478, osimertinib, BMS.599626, OSI.420, canertinib, afatinib, PD.168393, vandetanib, gefitinib, rociletinib, lapatinib, PD.153035, BIBX.1382",0.298432014944073,0.0535477349869269,FALSE
+"H1703","Pearson.est","Abl kinase inhibitor",0.35697,0.9,0.58,568,0.884,"imatinib, bafetinib, tozasertib, metatinib, KW.2449, bosutinib",0.236572006437063,0.0535477349869269,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",-0.53837,-1.37,0.157,1222,0.61,"nicotine, xanomeline",0.804100347590766,0.214670164989233,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.30375,-0.805,0.68,1393,1,"methscopolamine",0.167491087293764,0,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",0.55072,1.39,0.112,502,0.397,"CGS.15943, sulmazole, SCH.58261, MRS.1220",0.950781977329818,0.401209493236885,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",0.30805,0.768,0.753,552,1,"oxymetazoline, epinephrine, isoxsuprine, clenbuterol, terbutaline, methyldopa, A61603, norepinephrine",0.123205023799299,0,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",0.25876,0.647,0.875,179,0.992,"levobunolol, dronedarone, RS.17053, vincamine",0.0579919469776868,0.00348832784582135,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.64625,1.59,0.0469,107,0.52,"palomid.529, triciribine, uprosertib, CCT128930",1.32882715728492,0.283996656365201,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.30936,0.76,0.77,529,0.994,"NVP.TAE684, GW.788388, CEP.37440, AZD3463",0.113509274827518,0.00261361560268669,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",0.23735,0.585,0.931,355,0.952,"bicalutamide, cyproterone.acetate",0.0310503190186574,0.0213630516155257,FALSE
+"H1703","Pearson.est","antioxidant",-0.63063,-1.65,0.0446,1421,0.481,"trolox",1.35066514128786,0.317854923626168,FALSE
+"H1703","Pearson.est","AP inhibitor",0.54543,1.35,0.146,189,0.44,"embelin, LCL.161, GDC.0152",0.835647144215563,0.356547323513813,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.72755,-1.88,0.00959,1087,0.381,"omeprazole, digitoxin, digitoxigenin, blebbistatin...., NMS.873, evodiamine, digoxin, oligomycin.a, k.strophanthidin",2.01818139282934,0.419075024324381,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.3022,-0.785,0.716,977,0.923,"alisertib, AMG900, barasertib, danusertib, CCT137690, SNS.314, CYC116, CCT129202, TAK.901, PHA.680632, aurora.a.inhibitor.i, AT.9283",0.145086977692144,0.0347982989740879,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.4503,-1.15,0.281,1424,0.857,"josamycin",0.55129368009492,0.0670191780768018,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.35986,-0.926,0.518,1158,1,"norfloxacin, lomefloxacin, nadifloxacin",0.285670240254767,0,FALSE
+"H1703","Pearson.est","BCL inhibitor",-0.44314,-1.14,0.298,1118,0.733,"obatoclax, ABT.737, TW.37, gossypol",0.525783735923745,0.134896025358872,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.48373,1.2,0.254,398,0.558,"imatinib, bafetinib, tozasertib, metatinib",0.595166283380062,0.253365801062421,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.24082,0.596,0.913,650,0.963,"zaleplon, piperazine, ivermectin, CGS.20625, lorazepam, eprinomectin, nefiracetam, indiplon",0.039529222465701,0.0163737128754655,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",0.25937,0.644,0.883,651,0.975,"JQ1...., I.BET.762, bromosporine, OTX015",0.0540392964224314,0.0109953843014632,FALSE
+"H1703","Pearson.est","calcium channel blocker",-0.41244,-1.05,0.383,1191,0.876,"mibefradil, efonidipine.monoethanolate, carboxyamidotriazole",0.416801226031377,0.0574958938319193,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",0.37659,0.935,0.544,211,0.87,"navarixin, RS.504393",0.26440110030182,0.0604807473813815,FALSE
+"H1703","Pearson.est","CDK inhibitor",0.2913,0.729,0.799,386,0.972,"alvocidib, AZD5438, arcyriaflavin.a, kenpaullone, BMS.387032, PHA.793887, TG.02",0.0974532206860086,0.0123337350737254,FALSE
+"H1703","Pearson.est","CHK inhibitor",0.56965,1.44,0.116,240,0.393,"LY2603618, SCH.900776, LY2606368",0.935542010773082,0.405607449624573,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",0.44743,1.14,0.306,320,0.62,"indoprofen, amfenac, FK.3311, tryptanthrin, metoxibutropate, curcumin, meloxicam, FR.122047, acetylsalicylsalicylic.acid, ramifenazone, AM.404",0.51427857351842,0.207608310501746,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",0.41795,1.03,0.395,48,0.805,"itraconazole",0.40340290437354,0.0942041196321315,FALSE
+"H1703","Pearson.est","DNA alkylating agent",0.47643,1.17,0.259,475,0.589,"dacarbazine, TH.302, dianhydrogalactitol, streptozotocin, ifosfamide, estramustine, cisplatin, melphalan",0.586700235918748,0.229884705212898,FALSE
+"H1703","Pearson.est","DNA inhibitor",0.34829,0.857,0.611,17,0.919,"busulfan, nithiamide",0.213958789757446,0.0366844886138887,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",0.51707,1.29,0.19,368,0.493,"azacitidine, fdcyd, decitabine, SGI.1027",0.721246399047171,0.30715308072277,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",-0.30347,-0.789,0.689,437,0.957,"famciclovir, cephalomannine, cidofovir, idoxuridine, trifluridine, adefovir.dipivoxil, foscarnet, menadione",0.161780778092374,0.0190880622231565,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",0.33706,0.834,0.657,442,0.938,"altretamine, floxuridine, anisomycin, estramustine.phosphate, capecitabine, enocitabine, cisplatin",0.182434630440219,0.0277971616209356,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.24535,0.608,0.918,435,0.971,"isofloxythepin, ziprasidone, acetophenazine, mesoridazine, oxiperomide, amisulpride, paliperidone",0.0371573187987575,0.0127807700919951,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",-0.33787,-0.88,0.601,1196,1,"estrone, levonorgestrel, erteberel",0.22112552799726,0,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",0.30386,0.751,0.767,591,0.984,"raloxifene, toremifene, fulvestrant",0.115204636051019,0.00700490156865849,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.30946,-0.799,0.68,1376,0.984,"nintedanib, erdafitinib",0.167491087293764,0.00700490156865849,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",0.38237,0.951,0.496,92,0.864,"tandutinib, sunitinib, pacritinib",0.304518323509803,0.0634862575211067,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",-0.54845,-1.46,0.114,1102,0.617,"prednisolone.hemisuccinate, methylprednisolone, betamethasone, deflazacort, flumethasone.pivalate, fluocinolone.acetonide, triamcinolone, fluticasone.propionate, clobetasol.propionate, halcinonide, triamcinolone.acetonide, desonide, dexamethasone.acetate, beclomethasone.dipropionate, hydrocortisone",0.943095148663527,0.209714835966758,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.58621,1.46,0.104,111,0.388,"diazooxonorleucine, SIB.1757, latrepirdine, MTPG",0.98296666070122,0.411168274405793,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.52064,1.28,0.202,289,0.487,"AZD2858, GSK.3.inhibitor.IX, LY2090314, kenpaullone",0.694648630553376,0.312471038785366,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",-0.24705,-0.657,0.882,356,1,"GW.441756, GSK1838705A, lestaurtinib, AZD3463, GSK1904529A, danusertib, PHA.848125",0.0545314148681803,0,FALSE
+"H1703","Pearson.est","HCV inhibitor",0.75696,1.93,0.00348,187,0.183,"embelin, PSI.7976, Ro.9187, daclatasvir",2.45842075605342,0.737548910269571,TRUE
+"H1703","Pearson.est","HDAC inhibitor",0.60355,1.48,0.0889,307,0.417,"JNJ.26481585, tacedinaline, SB.939, M.344, vorinostat, panobinostat, R306465, romidepsin, RG2833, PCI.24781, nexturastat.a, ACY.1215, dacinostat",1.05109823902979,0.379863945026242,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.59234,1.52,0.0892,310,0.538,"chloropyramine, levocetirizine, terfenadine, zolantidine, tecastemizole, tiotidine, ICI.162846, ranitidine, cimetidine",1.04963514562388,0.269217724333611,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.31216,-0.816,0.647,1201,1,"lovastatin, atorvastatin",0.1890957193313,0,FALSE
+"H1703","Pearson.est","HSP inhibitor",0.60819,1.54,0.0607,360,0.571,"VER.49009, XL888, alvespimycin, guanidine, tanespimycin, SNX.5422, SNX.2112, PU.H71, BIIB021, NVP.AUY922",1.21681130892474,0.243363891754152,FALSE
+"H1703","Pearson.est","JAK inhibitor",0.26534,0.657,0.859,161,1,"atiprimod, pacritinib, LY2784544",0.0660068361687577,0,FALSE
+"H1703","Pearson.est","KIT inhibitor",0.59317,1.49,0.0859,459,0.484,"tandutinib, imatinib, sunitinib, telatinib, regorafenib, KI.8751, vatalanib, motesanib, OSI.930",1.06600683616876,0.315154638355588,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.24682,-0.637,0.882,1305,1,"AMG.232",0.0545314148681803,0,FALSE
+"H1703","Pearson.est","MEK inhibitor",0.30054,0.739,0.775,160,0.98,"BIX.02188, nobiletin, arctigenin",0.11069829749369,0.00877392430750515,FALSE
+"H1703","Pearson.est","MET inhibitor",0.57091,1.42,0.103,226,0.398,"AMG458, INC.280",0.987162775294828,0.400116927926312,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.23305,-0.607,0.916,1077,1,"triclabendazole, vinblastine, secnidazole, cytochalasin.b",0.0381045263321496,0,FALSE
+"H1703","Pearson.est","mTOR inhibitor",-0.20278,-0.527,0.977,1170,1,"voxtalisib, WYE.354, WYE.125132, XL388, OSI.027, torin.1, PF.04691502, SB.2343",0.0101054362812269,0,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.44003,-1.14,0.306,1428,0.733,"tyloxapol, EVP4593",0.51427857351842,0.134896025358872,FALSE
+"H1703","Pearson.est","opioid receptor agonist",0.32424,0.806,0.714,42,0.964,"salvinorin.a",0.146301788223826,0.0159229660971692,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.49636,1.22,0.246,615,0.547,"CMPD.1, TAK.715, skepinone.l, VX.702, SB.242235, SB.239063",0.609064892896621,0.262012673666569,FALSE
+"H1703","Pearson.est","PARP inhibitor",0.58946,1.46,0.106,507,0.388,"PJ.34, niraparib, olaparib, talazoparib, endo.IWR.1, E7449",0.97469413473523,0.411168274405793,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.50652,1.26,0.196,415,0.498,"tandutinib, trapidil, imatinib, sunitinib, telatinib, orantinib, regorafenib, KI.8751, vatalanib, motesanib",0.707743928643524,0.302770657240282,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.34728,-0.882,0.583,1298,1,"menadione, bis.maltolato.oxovanadium.IV., GSK2830371",0.234331445240986,0,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",0.28274,0.711,0.805,491,0.976,"papaverine, YM.976, GSK256066, EMD.53998, trequinsin, cilostamide",0.0942041196321315,0.0105501823333082,FALSE
+"H1703","Pearson.est","PI3K inhibitor",-0.20933,-0.556,0.959,1122,1,"AZD6482, GDC.0941, voxtalisib, PI.828, ZSTK.474, buparlisib, PF.04691502, SB.2343",0.0181813928293364,0,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.64979,-1.66,0.0354,1174,0.69,"GW.843682X, volasertib, NMS.1286937",1.45099673797421,0.161150909262745,FALSE
+"H1703","Pearson.est","potassium channel blocker",0.67074,1.68,0.026,199,0.376,"oleoylethanolamide, meglitinide",1.58502665202918,0.424812155072339,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",-0.3356,-0.875,0.588,1251,0.978,"fenofibrate, clofibrate",0.230622673923862,0.00966114521239857,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.65251,-1.64,0.0404,1168,0.375,"nomegestrol.acetate, levonorgestrel, tanaproget, norethindrone",1.3936186348894,0.425968732272281,FALSE
+"H1703","Pearson.est","proteasome inhibitor",0.69926,1.75,0.0189,343,0.303,"ixazomib.citrate, bortezomib, ixazomib, carfilzomib, ONX.0914, delanzomib",1.72353819582676,0.518557371497695,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.18251,-0.459,0.991,1025,0.992,"methacycline, bruceantin, cycloheximide, anguidine, clindamycin.phosphate, florfenicol, clofoctol, harringtonine",0.00392634551472468,0.00348832784582135,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.48176,-1.27,0.176,1400,0.74,"PP.121, mubritinib",0.75448733218585,0.130768280269024,FALSE
+"H1703","Pearson.est","RAF inhibitor",0.60322,1.48,0.0938,157,0.417,"CEP.32496, dabrafenib, vemurafenib, AZ.628, GDC.0879",1.02779716162094,0.379863945026242,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.71558,1.81,0.0155,297,0.278,"apatinib, sunitinib, vandetanib, regorafenib",1.80966830182971,0.555955204081924,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",-0.45289,-1.21,0.225,1340,0.789,"adapalene, adarotene, fenretinide",0.647817481888638,0.10292299679058,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",0.22045,0.547,0.961,454,0.959,"clofarabine, fludarabine.phosphate, gemcitabine, fludarabine, cladribine",0.0172766123314547,0.0181813928293364,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",-0.5439,-1.38,0.156,1256,0.685,"aripiprazole, zolmitriptan, NAN.190",0.806875401645538,0.164309428507574,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",0.36039,0.911,0.539,170,0.89,"SB.228357, RS.16566, ziprasidone",0.268411234813261,0.0506099933550872,FALSE
+"H1703","Pearson.est","sodium channel blocker",-0.30377,-0.78,0.697,1208,0.892,"oxcarbazepine, benzethonium, cibenzoline",0.156767221901991,0.0496351456238769,FALSE
+"H1703","Pearson.est","src inhibitor",0.41338,1.02,0.412,296,0.798,"saracatinib, KX2.391, PP.2",0.385102783966865,0.0979971086492706,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.37418,-0.983,0.445,1188,0.968,"chlormidazole, sulconazole, posaconazole",0.351639989019068,0.0141246426916063,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.56756,1.4,0.122,182,0.405,"LY2109761, D.4476, repsox",0.913640169325252,0.392544976785331,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",0.60845,1.5,0.0646,163,0.518,"doxifluridine, carmofur, raltitrexed",1.18976748200492,0.285670240254767,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",0.35768,0.894,0.597,29,0.871,"licochalcone.a, exatecan.mesylate, genz.644282",0.224025668870631,0.0599818449923368,FALSE
+"H1703","Pearson.est","tubulin polymerization inhibitor",0.256,0.637,0.894,347,0.962,"combretastatin.A.4, fosbretabulin, KX2.391, taltobulin, podophyllotoxin, mebendazole",0.0486624812040823,0.0168249279621871,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.26618,0.68,0.838,431,0.995,"apatinib, sunitinib, BMS.599626, tivantinib, vandetanib, rheochrysidin, regorafenib, bafetinib, AV.412, CP.724714",0.0767559813697235,0.00217691925427455,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",0.38717,0.957,0.503,415,0.91,"MGCD.265, sunitinib, golvatinib, lucitanib, tivozanib, telatinib, orantinib, vandetanib, regorafenib, PD.173074, KI.8751, foretinib, vatalanib, motesanib",0.298432014944073,0.0409586076789064,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.52833,1.31,0.176,290,0.485,"ercalcitriol, maxacalcitol, calcitriol, tacalcitol",0.75448733218585,0.314258261397736,FALSE
+"H460","Pearson.est","EGFR inhibitor",0.45216,1.23,0.235,338,0.652,"AZD8931, dacomitinib, poziotinib, CGP.52411, CNX.2006, canertinib, tucatinib, AST.1306, afatinib, CP.724714, pelitinib, BMS.690514, salvianolic.acid.B, GW.583340, WZ.3146, WZ8040, ARRY.334543, rociletinib",0.628932137728264,0.18575240426808,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.35853,-0.907,0.564,1296,0.792,"GZD824, bafetinib, KW.2449",0.248720896016658,0.101274818410506,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.31971,-0.796,0.718,1309,0.844,"tremorine",0.1438755557577,0.073657553374345,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.61147,1.66,0.0599,353,0.586,"methscopolamine, iododexetimide, dicycloverine, hyoscyamine",1.22257317761069,0.232102383981909,FALSE
+"H460","Pearson.est","adenosine receptor antagonist",0.51036,1.42,0.122,433,0.607,"istradefylline, CGS.15943, theophylline, MRS.1220",0.913640169325252,0.216811308924742,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",0.34769,0.932,0.517,289,0.803,"ritodrine, xylazine, isoetharine, A61603, lidamidine, methyldopa",0.286509456906058,0.095284454721319,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",0.34201,0.902,0.52,161,0.827,"RS.17053, atenolol...., atenolol......, prazosin, atipamezole",0.283996656365201,0.0824944904474534,FALSE
+"H460","Pearson.est","AKT inhibitor",0.2885,0.773,0.715,273,0.868,"AT7867, GSK2110183, A.674563, MK.2206",0.145693958198919,0.0614802748235081,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.48337,-1.21,0.25,918,0.693,"GW.788388, brigatinib, CEP.37440, lorlatinib, AZD3463, crizotinib, alectinib",0.602059991327962,0.159266765388193,FALSE
+"H460","Pearson.est","androgen receptor antagonist",0.2871,0.772,0.71,1034,0.841,"flutamide, cyproterone.acetate, RU.58841, nilutamide, enzalutamide, bicalutamide",0.148741651280925,0.0752040042020878,FALSE
+"H460","Pearson.est","antioxidant",-0.58298,-1.48,0.0938,1281,0.504,"mesna, chlorogenic.acid",1.02779716162094,0.297569463554475,FALSE
+"H460","Pearson.est","AP inhibitor",0.34813,0.934,0.505,946,0.924,"embelin, tanshinone.i, idronoxil, LCL.161, GDC.0152, birinapant",0.296708621881339,0.0343280287798933,FALSE
+"H460","Pearson.est","ATPase inhibitor",0.4938,1.31,0.185,243,0.612,"k.strophanthidin, omeprazole, evodiamine, oligomycin.a, blebbistatin....",0.732828271596986,0.213248577854439,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.5177,-1.3,0.164,1078,0.788,"tozasertib, AMG900, danusertib, CCT137690, GSK1070916, MK.8745, MLN.8054, MK.5108, KW.2449, hesperadin, PF.03814735",0.785156151952302,0.103473782510445,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34419,-0.864,0.642,1351,0.777,"azalomycin.b, azithromycin",0.192464971931147,0.109578981199086,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.43582,-1.12,0.323,1362,0.708,"finafloxacin, novobiocin",0.490797477668897,0.149966742310231,FALSE
+"H460","Pearson.est","BCL inhibitor",0.34983,0.94,0.508,99,0.963,"ABT.737, obatoclax",0.294136287716081,0.0163737128754655,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.36758,-0.928,0.536,1296,0.83,"GZD824, bafetinib",0.27083521030723,0.0809219076239261,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.28456,0.757,0.725,244,0.837,"temazepam, indiplon, CL.218872",0.139661993429006,0.07727454200674,FALSE
+"H460","Pearson.est","bromodomain inhibitor",0.52422,1.42,0.109,348,0.607,"I.BET151, I.BET.762, bromosporine",0.962573502059376,0.216811308924742,FALSE
+"H460","Pearson.est","calcium channel blocker",0.43034,1.15,0.299,240,0.703,"mibefradil, efonidipine.monoethanolate, tetrandrine, SKF.96365",0.52432881167557,0.153044674980176,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.47775,-1.23,0.212,1045,0.731,"ZK811752, RS.504393, UNBS.5162, navarixin",0.673664139071249,0.13608262304214,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.36064,-0.915,0.544,998,0.827,"PHA.793887, JNJ.7706621, palbociclib, ribociclib, BMS.265246, abemaciclib, kenpaullone, PHA.848125, alvocidib, NU6027, AZD5438",0.26440110030182,0.0824944904474534,FALSE
+"H460","Pearson.est","CHK inhibitor",-0.4908,-1.23,0.23,1176,0.731,"SCH.900776, LY2603618, LY2606368",0.638272163982407,0.13608262304214,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.37715,-0.972,0.485,1072,0.802,"meloxicam, amfenac, phenazone, aspirin, curcumin, FR.122047, ramifenazone, indoprofen, suxibuzone, acetylsalicylsalicylic.acid",0.314258261397736,0.0958256317158365,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",0.40179,1.08,0.354,285,0.8,"metyrapone, itraconazole, morin",0.450996737974212,0.0969100130080564,FALSE
+"H460","Pearson.est","DNA alkylating agent",-0.38599,-0.968,0.481,972,0.782,"satraplatin, dacarbazine, dianhydrogalactitol, melphalan, mitomycin.c, carboplatin, TH.302",0.317854923626168,0.106793246940152,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.53292,-1.35,0.145,1034,0.717,"tirapazamine, nithiamide, melphalan, sangivamycin, carboplatin, valrubicin, teroxirone",0.838631997765025,0.1444808443322,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.48792,-1.25,0.231,1039,0.792,"disulfiram, fdcyd, azacitidine, decitabine",0.636388020107856,0.101274818410506,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",0.63593,1.71,0.041,129,0.702,"cidofovir, menadione, adefovir.dipivoxil, famciclovir",1.38721614328026,0.153662887870195,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.47728,-1.2,0.246,1101,0.677,"CB.10.277, anisomycin, mitomycin.c, altretamine, cyclocytidine, floxuridine",0.609064892896621,0.169411331314856,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",0.31068,0.832,0.622,297,0.798,"nemonapride, remoxipride, lurasidone, mesoridazine, clebopride, raclopride",0.206209615309181,0.0979971086492706,FALSE
+"H460","Pearson.est","estrogen receptor agonist",0.27222,0.756,0.725,1056,0.812,"erteberel, ethinyl.estradiol, equol, PPT, estrone, estradiol.cypionate, levonorgestrel, estradiol",0.139661993429006,0.0904439707588247,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",0.58263,1.59,0.0576,5,0.582,"tamoxifen",1.23957751657679,0.235077015350112,FALSE
+"H460","Pearson.est","FGFR inhibitor",0.41466,1.15,0.279,224,0.703,"orantinib, erdafitinib, lenvatinib, nintedanib",0.554395796726402,0.153044674980176,FALSE
+"H460","Pearson.est","FLT3 inhibitor",0.21229,0.592,0.949,208,0.928,"GTP.14564, TG.02, TG.101348, sorafenib",0.0227337875727074,0.0324520237811379,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",0.49779,1.33,0.16,395,0.716,"hydrocortisone, piretanide, triamcinolone, halcinonide, triamcinolone.acetonide, difluprednate, deflazacort, betamethasone, dexamethasone.acetate, prednisolone.hemisuccinate, flumethasone.pivalate",0.795880017344075,0.145086977692144,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",-0.20201,-0.508,0.97,1234,0.996,"diazooxonorleucine, SIB.1757",0.0132282657337552,0.00174066157630127,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.41954,-1.03,0.418,1158,0.835,"tideglusib, LY2090314, kenpaullone",0.378823718224965,0.0783135245163979,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.78134,-1.92,0.00322,1147,0.185,"danusertib, AZD3463, lestaurtinib, GSK1838705A, PHA.848125, GW.441756",2.49214412830417,0.732828271596986,TRUE
+"H460","Pearson.est","HCV inhibitor",-0.35267,-0.911,0.534,1343,0.809,"daclatasvir",0.272458742971444,0.0920514783877277,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.41361,-1.06,0.376,1050,0.801,"JNJ.26481585, dacinostat, romidepsin, PCI.24781, entinostat, panobinostat, AR.42, givinostat, R306465, tacedinaline, chidamide",0.424812155072339,0.0963674839157623,FALSE
+"H460","Pearson.est","histamine receptor antagonist",-0.26424,-0.659,0.87,1082,0.965,"cyproheptadine, levocetirizine, astemizole, pheniramine, ranitidine, terfenadine, zolantidine",0.0604807473813815,0.0154726866562074,FALSE
+"H460","Pearson.est","HMGCR inhibitor",-0.30154,-0.751,0.768,907,0.889,"simvastatin, fluvastatin, mevastatin, pitavastatin",0.114638779968488,0.0510982390297863,FALSE
+"H460","Pearson.est","HSP inhibitor",-0.50524,-1.29,0.182,1202,0.748,"NVP.AUY922, ganetespib, PU.H71, SNX.2112, SNX.5422, BIIB021",0.739928612014925,0.126098402135539,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.21675,-0.545,0.96,1059,1,"ruxolitinib, tozasertib, baricitinib, lestaurtinib, WHI.P154",0.0177287669604316,0,FALSE
+"H460","Pearson.est","KIT inhibitor",0.33211,0.886,0.54,247,0.789,"cediranib, lenvatinib, telatinib, sorafenib, motesanib",0.267606240177031,0.10292299679058,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.74864,-1.91,0.00479,1265,0.104,"CGM097, serdemetan, idasanutlin, nutlin.3",2.31966448658544,0.98296666070122,TRUE
+"H460","Pearson.est","MEK inhibitor",-0.59967,-1.56,0.0628,1091,0.393,"arctigenin, nobiletin, PD.198306, AZD8330, refametinib, TAK.733, cobimetinib, MEK162, PD.184352, PD.0325901, Ro.4987655, AS.703026, PD.98059, trametinib",1.2020403562628,0.405607449624573,FALSE
+"H460","Pearson.est","MET inhibitor",-0.44207,-1.14,0.31,736,0.735,"LY2801653, NVP.BVU972, INC.280, PHA.665752, PF.04217903",0.508638306165727,0.133712660915805,FALSE
+"H460","Pearson.est","microtubule inhibitor",0.2736,0.755,0.743,239,0.789,"triclabendazole, colchicine, cytochalasin.b",0.129011186239425,0.10292299679058,FALSE
+"H460","Pearson.est","mTOR inhibitor",-0.46411,-1.16,0.298,1189,0.731,"GDC.0980, MLN0128, AZD2014, PI.103, sirolimus, NVP.BEZ235, ku.0063794, LY303511, PP242",0.525783735923745,0.13608262304214,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",0.38233,1.02,0.392,227,0.887,"tyloxapol, parthenolide, IKK.2.inhibitor.V",0.406713932979543,0.0520763801682736,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.40185,-1.02,0.419,967,0.824,"salvinorin.a, spiradoline, BW.180C",0.377785977033705,0.0840727883028842,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",-0.29351,-0.749,0.768,1098,0.871,"VX.702, CMPD.1",0.114638779968488,0.0599818449923368,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.71983,-1.82,0.00835,1384,0.161,"niraparib, talazoparib, olaparib",2.0783135245164,0.79317412396815,TRUE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.35308,0.932,0.509,247,0.803,"linifanib, orantinib, lenvatinib, telatinib, sorafenib, nintedanib, motesanib",0.293282217663241,0.095284454721319,FALSE
+"H460","Pearson.est","phosphatase inhibitor",0.30559,0.849,0.599,214,0.797,"GSK2830371, menadione, BVT.948",0.222573177610689,0.0985416786038876,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",-0.48668,-1.21,0.236,1143,0.693,"zardaverine, EMD.53998, papaverine, GSK256066, YM.976, trequinsin",0.627087997029893,0.159266765388193,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.34873,-0.867,0.616,1182,0.793,"alpelisib, GDC.0980, TG.100713, PI.103, PIK.75, NVP.BEZ235, LY303511",0.210419287835575,0.100726812682396,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.6662,-1.67,0.0268,960,0.287,"rigosertib, volasertib, GW.843682X, NMS.1286937, BI.2536, HMN.214, GSK461364",1.57186520597121,0.542118103266008,FALSE
+"H460","Pearson.est","potassium channel blocker",-0.35215,-0.889,0.567,1285,0.779,"oleoylethanolamide, meglitinide",0.246416941107093,0.108462542327436,FALSE
+"H460","Pearson.est","PPAR receptor agonist",0.5819,1.58,0.0575,143,0.481,"GW.501516, fenofibrate, pterostilbene, S26948",1.24033215531037,0.317854923626168,FALSE
+"H460","Pearson.est","progesterone receptor agonist",0.48323,1.32,0.182,515,0.658,"norgestrel, melengestrol.acetate, norethindrone, nomegestrol.acetate, tanaproget, danazol",0.739928612014925,0.181774106386044,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.21806,0.607,0.923,1134,0.943,"carfilzomib, oprozomib, ONX.0914, ixazomib.citrate, bortezomib, MG.132, ixazomib, delanzomib",0.0347982989740879,0.0254883072626717,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.36099,-0.904,0.593,1040,0.775,"chloramphenicol.palmitate, emetine, homoharringtonine, mercaptopurine, cycloheximide, thiostrepton, brefeldin.a",0.226945306635737,0.11069829749369,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",0.365,0.996,0.441,534,0.888,"CP.724714, rheochrysidin, PP.121, BMS.599626, AV.412",0.355561410532161,0.051587034221399,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.34129,-0.855,0.636,1079,0.771,"CEP.32496, regorafenib, RAF265, vemurafenib, SB.590885, LGX818",0.196542884351586,0.112945621949043,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.23976,-0.614,0.909,1058,0.99,"cabozantinib, regorafenib",0.0414361167780325,0.00436480540245009,FALSE
+"H460","Pearson.est","retinoid receptor agonist",0.31573,0.857,0.591,12,0.813,"fenretinide",0.228412519118745,0.0899094544059319,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.56398,-1.43,0.0953,1141,0.564,"gemcitabine, cladribine, clofarabine, hydroxyurea, fludarabine.phosphate, fludarabine",1.02090709936167,0.248720896016658,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.37849,-0.972,0.492,1447,0.802,"aripiprazole",0.30803489723264,0.0958256317158365,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.40208,-1.01,0.437,1066,0.814,"SB.216641, RS.16566, SB.228357, ziprasidone, SB.200646, aripiprazole",0.359518563029578,0.0893755951107988,FALSE
+"H460","Pearson.est","sodium channel blocker",-0.2157,-0.539,0.949,1063,1,"ajmaline, butamben, brivaracetam, mexiletine",0.0227337875727074,0,FALSE
+"H460","Pearson.est","src inhibitor",0.45249,1.23,0.239,109,0.652,"ZM.306416, PP.1",0.621602099051862,0.18575240426808,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.38757,-0.979,0.478,1268,0.849,"ketoconazole, lanoconazole",0.320572103387881,0.0710923097560473,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",0.83628,2.3,0,156,0.011,"SB.431542, adaprev, SB.525334, repsox",Inf,1.95860731484178,TRUE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.6704,-1.71,0.0217,1352,0.272,"carmofur, raltitrexed",1.66354026615147,0.565431095965801,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.64183,-1.61,0.0473,1307,0.348,"voreloxin, topotecan, nemorubicin, irinotecan, SN.38, TAS.103, camptothecin, amonafide, valrubicin, rubitecan, exatecan.mesylate, mitoxantrone, genz.644282, amsacrine",1.32513885926219,0.458420756053419,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.45879,-1.13,0.33,1014,0.721,"oxibendazole, ABT.751, vinblastine, podophyllotoxin, epothilone.b, fosbretabulin, verubulin, KX2.391, combretastatin.A.4, taltobulin, mebendazole, BNC105",0.481486060122112,0.142064735280571,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.17593,-0.438,0.99,1341,0.993,"bafetinib, AMG.208",0.00436480540245009,0.00305075150461883,FALSE
+"H460","Pearson.est","VEGFR inhibitor",0.35008,0.933,0.497,254,0.881,"cediranib, ZM.306416, linifanib, orantinib, lenvatinib, telatinib, sorafenib, nintedanib, motesanib, BMS.690514",0.303643611266668,0.0550240915879521,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",0.33922,0.887,0.583,87,0.821,"alfacalcidol, paricalcitol",0.234331445240986,0.0856568428805592,FALSE
+"H520","Pearson.est","EGFR inhibitor",0.2953,0.77,0.716,446,0.928,"WZ.3146, vandetanib, WZ8040, pelitinib, CNX.2006, icotinib, AST.1306, rociletinib, canertinib, CGP.52411, BMS.690514, afatinib, BIBU.1361, erlotinib, tyrphostin.AG.494, PD.168393, BIBX.1382, osimertinib, poziotinib, OSI.420, dacomitinib",0.145086977692144,0.0324520237811379,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",0.46455,1.21,0.245,122,0.752,"flumatinib, KW.2449, ZM.306416",0.610833915635468,0.123782159408358,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",0.30794,0.812,0.667,334,0.938,"nefiracetam, xanomeline",0.175874166083451,0.0277971616209356,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",0.29304,0.774,0.716,383,0.948,"iododexetimide, dicycloverine, methscopolamine",0.145086977692144,0.0231916626619338,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",0.60499,1.54,0.0795,412,0.564,"theophylline, MRS.1220, sulmazole, istradefylline, CGS.15943",1.09963287134353,0.248720896016658,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.50026,1.3,0.187,288,0.774,"oxymetazoline, A61603, terbutaline, norepinephrine, clenbuterol, buphenine, midodrine, isoetharine",0.728158393463501,0.111259039317107,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",-0.34977,-0.909,0.56,1323,0.748,"naftidrofuryl, prazosin, idazoxan, vincamine",0.2518119729938,0.126098402135539,FALSE
+"H520","Pearson.est","AKT inhibitor",0.44477,1.12,0.332,186,0.862,"AT7867, palomid.529, CCT128930, MK.2206",0.478861916295964,0.0644927341752872,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.39327,-1.04,0.394,1252,0.559,"AZD3463, CEP.37440, crizotinib",0.404503778174426,0.252588192113577,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.35,0.92,0.509,319,0.939,"bicalutamide, RU.58841",0.293282217663241,0.0273344077338891,FALSE
+"H520","Pearson.est","antioxidant",0.38898,1.01,0.415,23,0.894,"benfotiamine",0.381951903287907,0.0486624812040823,FALSE
+"H520","Pearson.est","AP inhibitor",0.47856,1.25,0.235,63,0.832,"birinapant",0.628932137728264,0.0798766737092761,FALSE
+"H520","Pearson.est","ATPase inhibitor",-0.49169,-1.27,0.193,1298,0.435,"omeprazole, digitoxigenin, NMS.873, rabeprazole, digoxin",0.714442690992226,0.361510743045363,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",0.20248,0.517,0.976,436,0.971,"KW.2449, ZM.447439, CYC116, hesperadin, MLN.8054, alisertib, GSK1070916, SNS.314, AT.9283",0.0105501823333082,0.0127807700919951,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.46229,-1.19,0.265,1090,0.501,"radezolid, tedizolid, dirithromycin, azithromycin, azalomycin.b",0.576754126063192,0.300162274132754,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.63495,1.66,0.0333,302,0.461,"trovafloxacin, novobiocin, sparfloxacin, finafloxacin",1.47755576649368,0.336299074610352,FALSE
+"H520","Pearson.est","BCL inhibitor",0.41446,1.07,0.351,554,0.884,"ABT.737, TW.37, HA14.1, gossypol, oridonin",0.454692883534176,0.0535477349869269,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.27323,0.687,0.838,282,0.932,"flumatinib, dasatinib",0.0767559813697235,0.0305840876460186,FALSE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.5143,1.34,0.165,344,0.743,"lorazepam, temazepam, CGS.20625, gamma.aminobutyric.acid, nefiracetam, indiplon",0.782516055786094,0.129011186239425,FALSE
+"H520","Pearson.est","bromodomain inhibitor",0.26976,0.694,0.829,1059,0.97,"bromosporine, PFI.1, I.BET151, OTX015, I.BET.762, JQ1....",0.0814454694497265,0.0132282657337552,FALSE
+"H520","Pearson.est","calcium channel blocker",0.27305,0.693,0.825,231,0.947,"efonidipine.monoethanolate, mibefradil",0.0835460514500749,0.0236500209967266,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",-0.41589,-1.09,0.321,1055,0.51,"PF.04136309, SB.225002, UNBS.5162, navarixin, ZK811752",0.493494967595128,0.292429823902064,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.54512,-1.44,0.118,1069,0.371,"indisulam, PHA.793887, dinaciclib, alvocidib, ribociclib, JNJ.7706621, NU6027, abemaciclib, arcyriaflavin.a, AZD5438, BMS.387032, BMS.265246, PHA.848125",0.928117992693875,0.430626090384954,FALSE
+"H520","Pearson.est","CHK inhibitor",0.35428,0.907,0.558,44,0.932,"AZD7762",0.253365801062421,0.0305840876460186,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",0.25017,0.628,0.918,394,0.934,"metoxibutropate, ketoprofen, piroxicam, indoprofen, tryptanthrin, FR.122047, phenylbutazone",0.0371573187987575,0.0296531237699066,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.7039,1.82,0.0198,298,0.638,"itraconazole, cobicistat, eplerenone, morin",1.70333480973847,0.195179321278838,FALSE
+"H520","Pearson.est","DNA alkylating agent",-0.43882,-1.15,0.275,1109,0.539,"temozolomide, satraplatin, cyclophosphamide, melphalan, dacarbazine, mitomycin.c",0.560667306169737,0.268411234813261,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.59322,-1.53,0.0596,1221,0.348,"busulfan, melphalan, nimorazole, bendamustine, teroxirone, sangivamycin, metronidazole",1.22475374025976,0.458420756053419,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.42454,-1.09,0.369,1094,0.51,"disulfiram, SGI.1027, azacitidine, fdcyd, decitabine",0.43297363384094,0.292429823902064,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",0.56362,1.45,0.108,342,0.556,"cephalomannine, menadione, cidofovir, famciclovir",0.96657624451305,0.254925208417942,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.33903,-0.853,0.628,1133,0.762,"altretamine, cyclocytidine, floxuridine, nelarabine, enocitabine, mitomycin.c",0.202040356262804,0.1180450286604,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",0.40137,1.01,0.418,257,0.894,"nemonapride, UH.232...., acetophenazine, clebopride, raclopride, lurasidone",0.378823718224965,0.0486624812040823,FALSE
+"H520","Pearson.est","estrogen receptor agonist",0.28055,0.723,0.793,39,0.978,"PPT",0.100726812682396,0.00966114521239857,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",-0.59167,-1.55,0.07,1011,0.364,"tamoxifen, toremifene, raloxifene",1.15490195998574,0.438898616350944,FALSE
+"H520","Pearson.est","FGFR inhibitor",-0.52363,-1.4,0.12,1311,0.396,"nintedanib, dovitinib, lenvatinib, regorafenib",0.920818753952375,0.402304814074488,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.43227,-1.11,0.317,1218,0.549,"sorafenib, ENMD.2076, lestaurtinib, pacritinib, tyrphostin.AG.1296, dovitinib, TG.101348",0.498940737782249,0.260427655549908,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",0.37651,0.977,0.478,474,0.926,"piretanide, hydrocortisone, deflazacort, prednisolone.hemisuccinate, flumethasone.pivalate, clobetasol.propionate, triamcinolone, fludroxycortide, prednisolone, fluocinolone.acetonide, rimexolone, methylprednisolone",0.320572103387881,0.0333890133180656,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",0.47641,1.21,0.266,232,0.752,"latrepirdine, JNJ.16259685, SIB.1757, LY456236, kynurenic.acid",0.575118363368933,0.123782159408358,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.46229,1.23,0.222,535,0.819,"LY2090314, indirubin, CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.653647025549361,0.0867160982395816,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.71483,-1.86,0.019,1252,0.218,"AZD3463, lestaurtinib, GW.441756, danusertib, PHA.848125",1.72124639904717,0.661543506395395,TRUE
+"H520","Pearson.est","HCV inhibitor",0.41397,1.07,0.364,83,0.884,"Ro.9187",0.438898616350944,0.0535477349869269,FALSE
+"H520","Pearson.est","HDAC inhibitor",0.31492,0.835,0.642,289,0.985,"romidepsin, RG2833, RGFP966, pyroxamide, nexturastat.a, mocetinostat, belinostat, JNJ.26481585",0.192464971931147,0.00656376950238827,FALSE
+"H520","Pearson.est","histamine receptor antagonist",0.6157,1.54,0.0606,242,0.564,"chloropyramine, BF2.649, epinastine, ICI.162846, famotidine, terfenadine, lafutidine, pheniramine, tiotidine",1.21752737583371,0.248720896016658,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.64774,1.73,0.0233,230,0.609,"pitavastatin, atorvastatin, fluvastatin",1.63264407897398,0.215382707367125,FALSE
+"H520","Pearson.est","HSP inhibitor",0.2583,0.67,0.834,573,0.93,"KW.2478, VER.49009, alvespimycin, guanidine, SNX.5422, ganetespib, BIIB021, NVP.AUY922",0.0788339493622613,0.0315170514460649,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.50653,-1.32,0.179,1290,0.392,"lestaurtinib, pacritinib, LY2784544, baricitinib, TG.101348",0.747146969020107,0.406713932979543,FALSE
+"H520","Pearson.est","KIT inhibitor",-0.32437,-0.844,0.65,1214,0.752,"OSI.930, sorafenib, pazopanib, lenvatinib, regorafenib",0.187086643357144,0.123782159408358,FALSE
+"H520","Pearson.est","MDM inhibitor",0.37674,0.961,0.471,198,0.886,"RITA, serdemetan",0.326979092871104,0.0525662781129492,FALSE
+"H520","Pearson.est","MEK inhibitor",0.27973,0.71,0.818,453,0.972,"PD.184352, U.0126, TAK.733, BIX.02188, refametinib, arctigenin, PD.98059, AZD8330",0.087246696328677,0.0123337350737254,FALSE
+"H520","Pearson.est","MET inhibitor",-0.31873,-0.84,0.629,851,0.734,"NVP.BVU972, PF.04217903, PHA.665752, INC.280",0.201349354554731,0.134303940083929,FALSE
+"H520","Pearson.est","microtubule inhibitor",-0.33497,-0.856,0.628,1004,0.783,"cabazitaxel, vinblastine, secnidazole, podophyllotoxin, D.64131, vinflunine",0.202040356262804,0.106238237942057,FALSE
+"H520","Pearson.est","mTOR inhibitor",-0.52148,-1.37,0.124,1114,0.379,"WAY.600, voxtalisib, sirolimus, GSK2126458, OSI.027, XL388, WYE.125132, NVP.BEZ235, WYE.354, PP242, AZD8055, ku.0063794, MLN0128, AZD2014",0.906578314837765,0.421360790031928,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",0.35054,0.905,0.563,238,0.903,"BAY.11.7085, tyloxapol, IKK.2.inhibitor.V",0.249491605148654,0.0443122496864942,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.5862,1.53,0.0857,10,0.441,"cebranopadol",1.0670191780768,0.355561410532161,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.6469,-1.67,0.0377,1447,0.289,"talmapimod",1.42365864979421,0.539102157243452,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.31794,-0.828,0.631,1143,0.728,"olaparib, niraparib, PJ.34",0.199970640755866,0.137868620686963,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30233,-0.789,0.699,1218,0.764,"sorafenib, crenolanib, pazopanib, nintedanib, dovitinib, lenvatinib, regorafenib",0.155522824254319,0.11690664142431,FALSE
+"H520","Pearson.est","phosphatase inhibitor",0.25385,0.645,0.889,351,0.938,"menadione, mycophenolate.mofetil, CID.5458317",0.0510982390297863,0.0277971616209356,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",0.6023,1.53,0.0694,455,0.441,"papaverine, anagrelide, avanafil, GSK256066, YM.976, EMD.53998, enoximone",1.15864052954514,0.355561410532161,FALSE
+"H520","Pearson.est","PI3K inhibitor",-0.33652,-0.869,0.609,992,0.789,"GDC.0941, PKI.179, PF.04691502, PIK.75, voxtalisib, GSK2126458, CUDC.907, alpelisib, YM.201636, NVP.BEZ235, PI3K.IN.2, idelalisib, CH5132799",0.215382707367125,0.10292299679058,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.79685,-2.09,0.0021,1232,0.0474,"GSK461364, HMN.214, volasertib, BI.2536, GW.843682X, NMS.1286937",2.67778070526608,1.32422165832591,TRUE
+"H520","Pearson.est","potassium channel blocker",0.33669,0.879,0.605,482,0.925,"meglitinide, ibutilide, dofetilide, mepivacaine",0.218244625347531,0.0338582672609674,FALSE
+"H520","Pearson.est","PPAR receptor agonist",0.38481,0.974,0.449,312,0.894,"S26948, fenofibrate",0.347753658996677,0.0486624812040823,FALSE
+"H520","Pearson.est","progesterone receptor agonist",0.29853,0.779,0.722,281,0.968,"norgestrel, tanaproget, norethindrone",0.141462802430361,0.0141246426916063,FALSE
+"H520","Pearson.est","proteasome inhibitor",0.31928,0.83,0.645,456,0.933,"ixazomib.citrate, ONX.0914, oprozomib",0.190440285364732,0.0301183562535,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.56844,-1.47,0.0933,1217,0.361,"emetine, anguidine, tedizolid.phosphate, clofoctol, bruceantin, harringtonine, homoharringtonine, chloramphenicol.palmitate",1.0301183562535,0.442492798094342,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.28035,-0.727,0.766,1087,0.829,"BMS.599626, tyrphostin.A9, mubritinib",0.115771230367396,0.0814454694497265,FALSE
+"H520","Pearson.est","RAF inhibitor",-0.59037,-1.56,0.0748,1156,0.407,"vemurafenib, sorafenib, SB.590885, RAF265, LGX818, AZ.628, regorafenib",1.12609840213554,0.39040559077478,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.43547,-1.13,0.325,1218,0.543,"sorafenib, regorafenib",0.488116639021126,0.265200170411153,FALSE
+"H520","Pearson.est","retinoid receptor agonist",-0.50666,-1.32,0.159,1075,0.392,"bexarotene, adapalene, tamibarotene, adarotene, AM.580",0.798602875679548,0.406713932979543,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.41694,-1.09,0.362,1206,0.51,"hydroxyurea, fludarabine.phosphate, pentostatin",0.441291429466834,0.292429823902064,FALSE
+"H520","Pearson.est","serotonin receptor agonist",0.64501,1.67,0.0379,1,0.582,"aripiprazole",1.42136079003193,0.235077015350112,FALSE
+"H520","Pearson.est","serotonin receptor antagonist",0.46331,1.2,0.259,257,0.726,"aripiprazole, lerisetron, RS.16566, tropisetron, lurasidone",0.586700235918748,0.139063379299906,FALSE
+"H520","Pearson.est","sodium channel blocker",0.21041,0.544,0.967,482,0.978,"quinidine, A.803467, lappaconite, ajmaline, benzethonium, mepivacaine",0.0145735259169983,0.00966114521239857,FALSE
+"H520","Pearson.est","src inhibitor",0.32471,0.834,0.642,122,0.955,"PP.2, ZM.306416",0.192464971931147,0.0199966284162537,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",-0.70024,-1.83,0.0162,1280,0.18,"sulconazole, chlormidazole, ketoconazole, lanoconazole",1.79048498545737,0.744727494896694,TRUE
+"H520","Pearson.est","TGF beta receptor inhibitor",0.40364,1.03,0.402,239,0.934,"D.4476",0.39577394691553,0.0296531237699066,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",-0.69561,-1.8,0.0164,1108,0.17,"raltitrexed, carmofur, trifluridine, ftorafur",1.7851561519523,0.769551078621726,TRUE
+"H520","Pearson.est","topoisomerase inhibitor",-0.45572,-1.2,0.228,1184,0.511,"camptothecin, genz.644282, amsacrine, nemorubicin, etoposide.phosphate, topotecan, mitoxantrone, dexrazoxane, SN.38",0.642065152999546,0.291579099865287,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.53243,-1.38,0.143,917,0.393,"paclitaxel, vincristine, dolastatin.10, epothilone.b, docetaxel, vindesine, vinblastine, combretastatin.A.4, oxibendazole, CYT.997, verubulin, fenbendazole, ABT.751, podophyllotoxin, plinabulin, BNC105, taltobulin, KX2.391, mebendazole",0.844663962534938,0.405607449624573,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",-0.25292,-0.66,0.871,1087,0.863,"BMS.599626, tyrphostin.AG.99, bafetinib, tyrphostin.A9, sorafenib, mubritinib, tivantinib, regorafenib",0.0599818449923368,0.0639892042847904,FALSE
+"H520","Pearson.est","VEGFR inhibitor",-0.25801,-0.68,0.86,1214,0.865,"OSI.930, sorafenib, ENMD.2076, RAF265, pazopanib, nintedanib, foretinib, dovitinib, lenvatinib, regorafenib",0.0655015487564323,0.0629838925351858,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",-0.58542,-1.51,0.08,1227,0.337,"calcitriol, maxacalcitol, doxercalciferol",1.09691001300806,0.472370099128661,FALSE
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--- /dev/null
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@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-6220ca443d6e15c61c3e" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_mean_results.csv
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@@ -0,0 +1,182 @@
+"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.671066666666667,1.25372128747448,0.000426182074797522,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.00213091037398761
+"KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.595533333333333,1.1644635715744,0.10538060181695,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1650",0.2107612036339
+"KEGG_O_GLYCAN_BIOSYNTHESIS",0.593666666666667,1.73656523330505,1.30448296897215e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"H1650, H2009, H2126, H3255, H1299, H1703",3.35438477735696e-06
+"KEGG_SPLICEOSOME",0.544866666666667,1.10170166214858,0.0702248665386982,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.151223108390862
+"KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.527933333333333,1.51368700608182,1.78300678980218e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, H2009, H1703",1.88788954214348e-05
+"KEGG_ETHER_LIPID_METABOLISM",0.510133333333333,1.36421159160398,0.00022153062354379,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H1650, H2009, HCC15, H1299",0.00141196252453187
+"KEGG_SPHINGOLIPID_METABOLISM",0.499066666666667,1.20477096025206,0.0191483360923705,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H460",0.0485450774172773
+"KEGG_VIRAL_MYOCARDITIS",0.476933333333333,1.1351842812429,0.0484473424986856,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.112490195578313
+"KEGG_MISMATCH_REPAIR",0.4562,1.31209849368973,0.00312392037222046,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H358",0.0114756258571364
+"KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.445933333333333,1.12665722171302,0.0772475532879669,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1650",0.162256925794493
+"KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.4268,1.75512535978813,3.90704348207531e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"HCC95, H2009, HCC15, H1299, H460, H520",6.7064447155462e-06
+"KEGG_CELL_ADHESION_MOLECULES_CAMS",0.4218,1.3733701093088,0.000761213320407723,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.00351329224803564
+"KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.4216,1.11629942219818,0.100978242437355,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.206546404985499
+"KEGG_ABC_TRANSPORTERS",0.404933333333333,1.42574313788918,0.00168316203119409,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, H358, HCC15, H460",0.00673264812477634
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.388285714285714,1.69462895546586,1.47530814022101e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,5,"H1650, H2009, H2126, H358, HCC15",7.19281879832146e-07
+"KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.3882,0.920117554601429,0.7572091187989,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.885049619375338
+"KEGG_HOMOLOGOUS_RECOMBINATION",0.3702,1.16894343013558,0.0683533960586392,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.150511677944397
+"KEGG_PROTEASOME",0.363533333333333,0.98287594527973,0.609425235874158,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.761781544842697
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3628,1.27145216189993,0.020464111084835,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, HCC15",0.0511602777120874
+"KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.357666666666667,1.25015819951298,0.0128034339470889,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0349184562193333
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.347538461538462,1.52767861014594,0.0124461230963727,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1703, H460, H520",13,4,"H2009, H2126, HCC15, H460",0.0349184562193333
+"KEGG_SELENOAMINO_ACID_METABOLISM",0.345,1.15678427424601,0.104142599652175,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.210625482442601
+"KEGG_CARDIAC_MUSCLE_CONTRACTION",0.3406,1.11980143648008,0.158927184909564,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.28323656716556
+"KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.3348,1.23347807902231,0.0228762241976909,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC15, H520",0.0549029380744581
+"KEGG_OTHER_GLYCAN_DEGRADATION",0.315666666666667,1.37681888354832,0.0011544930492352,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.00506850606981308
+"KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.314666666666667,1.42311407366615,0.000416775295504676,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.00213091037398761
+"KEGG_CITRATE_CYCLE_TCA_CYCLE",0.313133333333333,1.01377299985652,0.458354837744466,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.625029324197
+"KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.29,1.73812542700462,5.38240751787206e-07,"HCC827, HCC95, H1650, H1975, H2009, H3255, H358, H1299, H1703, H460, H520",11,3,"H358, H1299, H520",8.07361127680809e-06
+"KEGG_DILATED_CARDIOMYOPATHY",0.28,1.40528817583543,0.000506445531726697,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00246378907326501
+"KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.274466666666667,1.35546043134884,0.00376030931188481,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0135371135227853
+"KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.271,1.16437003200382,0.100937533549697,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.206546404985499
+"KEGG_PYRIMIDINE_METABOLISM",0.267666666666667,0.767341576638524,0.999504660123495,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.266066666666667,1.03914143590251,0.50616180580069,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.660211051044379
+"KEGG_ARACHIDONIC_ACID_METABOLISM",0.266,1.55640060946495,1.72156426113164e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1299, H1703",1.88788954214348e-05
+"KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.252733333333333,1.0967609758262,0.295335665109728,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.443003497664592
+"KEGG_FATTY_ACID_METABOLISM",0.236266666666667,1.1716406364378,0.118053474997529,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.223680268416371
+"KEGG_PROTEIN_EXPORT",0.233333333333333,1.0715536561905,0.468287274777629,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H520",0.631330518007783
+"KEGG_PARKINSONS_DISEASE",0.2306,0.954130778697104,0.800212157429862,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.917440690046976
+"KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.227533333333333,1.16543228440086,0.137038529084978,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.249160961972687
+"KEGG_RNA_DEGRADATION",0.2268,0.862700842040358,0.972144204552248,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.225,1.17462516817676,0.142172924522516,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.255911264140528
+"KEGG_HUNTINGTONS_DISEASE",0.219866666666667,0.758205293219895,0.999211940353133,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.214333333333333,1.6541561796477,0.00245314496198085,"H1975, H2009, H2126, H3255, A549, H1703",6,2,"H2009, H2126",0.0091992936074282
+"KEGG_RIBOSOME",0.207133333333333,1.44952587650813,0.00022748285117458,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.00141196252453187
+"KEGG_RIBOFLAVIN_METABOLISM",0.205333333333333,1.55470652566727,6.36883715403337e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",5.1910931146388e-05
+"KEGG_DNA_REPLICATION",0.2044,1.34259284329135,0.00568311834312175,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0196723327261907
+"KEGG_BASAL_TRANSCRIPTION_FACTORS",0.1936,1.16100029531189,0.172053004027568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.297784045432329
+"KEGG_TASTE_TRANSDUCTION",0.171066666666667,1.44532134176189,0.000311366612587233,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H1650, H1299, H460",0.00175143719580319
+"KEGG_ADHERENS_JUNCTION",0.1706,1.0273442739135,0.594536006222527,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.753637190986302
+"KEGG_TRYPTOPHAN_METABOLISM",0.169933333333333,1.36502336278629,0.00402253595459586,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H358, H1299, H520",0.014197185722103
+"KEGG_N_GLYCAN_BIOSYNTHESIS",0.149333333333333,1.08579810453395,0.408726180857809,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.565928558110812
+"KEGG_TIGHT_JUNCTION",0.1442,1.12278678805398,0.26004746309588,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.400073020147507
+"KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.141066666666667,1.43737173175143,0.000546682107846546,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00258954682664153
+"KEGG_PURINE_METABOLISM",0.140333333333333,0.844700425904835,0.994520213682643,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_FOCAL_ADHESION",0.1352,1.14599384191813,0.184094398342539,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.306823997237565
+"KEGG_LYSOSOME",0.1334,1.23926837863544,0.048745751417269,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H3255",0.112490195578313
+"KEGG_ARGININE_AND_PROLINE_METABOLISM",0.132666666666667,1.15887899446384,0.18244461202891,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.306823997237565
+"KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.128066666666667,1.41091887316977,0.00156311584519203,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00639456482124013
+"KEGG_GLYCEROLIPID_METABOLISM",0.1274,1.14553068176158,0.209877187255361,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.340341384738422
+"KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.1268,1.55134937577397,0.000325400486602347,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H1703",0.00177491174510371
+"KEGG_RNA_POLYMERASE",0.104066666666667,1.33016220636361,0.0121868800871744,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.0348196573919267
+"KEGG_CALCIUM_SIGNALING_PATHWAY",0.100533333333333,0.991397416829012,0.790022324675496,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.911564220779419
+"KEGG_ECM_RECEPTOR_INTERACTION",0.0853333333333332,1.61384132104857,1.20191109327206e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2009, H1299, H1703, H460",1.54531426277836e-05
+"KEGG_BASAL_CELL_CARCINOMA",0.079,1.46966215748479,0.000245546677109744,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.00147328006265847
+"KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.0714000000000001,1.69878384229929,1.71994518615006e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H358, HCC15, H1299, H520",3.86987666883764e-06
+"KEGG_NOTCH_SIGNALING_PATHWAY",0.0688666666666667,1.1185900478898,0.309422039085118,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.452812740124564
+"KEGG_OXIDATIVE_PHOSPHORYLATION",0.0652,0.948735865695581,0.845887167877184,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H460",0.951623063861832
+"KEGG_PEROXISOME",0.0530666666666666,1.22113650030656,0.0705707839157357,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.151223108390862
+"KEGG_LONG_TERM_POTENTIATION",0.0485333333333333,0.918778759834929,0.95239959631585,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_NON_HOMOLOGOUS_END_JOINING",0.0358666666666667,1.33999013144909,0.00685695274264554,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0224409362486581
+"KEGG_LEISHMANIA_INFECTION",0.0221333333333334,1.30260754240247,0.0147954449774412,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0391644131755798
+"KEGG_BETA_ALANINE_METABOLISM",0.000733333333333401,1.32176021526851,0.00998730871744822,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, H1299",0.0294707470350931
+"KEGG_GNRH_SIGNALING_PATHWAY",-0.00473333333333329,0.930174904187891,0.956338012963406,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.00646666666666668,0.857701818538243,0.995692009323155,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.00813333333333336,1.32298897882607,0.0064295596276342,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H2009, H358, H1299",0.0214710294257406
+"KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.0186,1.28254572739421,0.0180458086585579,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H1299",0.0464035079791488
+"KEGG_PHENYLALANINE_METABOLISM",-0.019,1.59507299429928,6.63306342426068e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, HCC15, H1299, H520",5.1910931146388e-05
+"KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.0240000000000001,1.18978623530208,0.115004526323932,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.222589405788256
+"KEGG_GAP_JUNCTION",-0.0400666666666666,0.999390347495245,0.768552374418437,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.892512434808508
+"KEGG_APOPTOSIS",-0.0443333333333333,0.960622987341821,0.903804460103794,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.998066274961245
+"KEGG_LONG_TERM_DEPRESSION",-0.0611333333333334,0.914045627703459,0.970529640015843,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_BASE_EXCISION_REPAIR",-0.0684666666666666,1.13212530014928,0.307863235285446,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.452812740124564
+"KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.0713333333333334,1.69679052780185,2.14645829478055e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H358, HCC15, H1299, H520",2.14645829478055e-05
+"KEGG_LYSINE_DEGRADATION",-0.0741333333333333,1.08975671378436,0.486454890935122,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.639137812907459
+"KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.0758666666666667,0.897194346414474,0.980707634624924,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.0759333333333333,0.97243093523886,0.858707730805452,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.960045910217275
+"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.0765333333333333,1.16611068248667,0.223961608027633,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.353623591622579
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.0912666666666667,1.3454995071755,0.00812248060042913,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1703, H520",0.0247804492894448
+"KEGG_PYRUVATE_METABOLISM",-0.0932666666666667,1.0501283232244,0.599400430742815,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.754490052683264
+"KEGG_SMALL_CELL_LUNG_CANCER",-0.0990666666666667,1.16124615740817,0.180272984935311,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.30649421315758
+"KEGG_ALZHEIMERS_DISEASE",-0.0995333333333334,0.843619655893296,0.996041425215107,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_PRIMARY_IMMUNODEFICIENCY",-0.109,1.47902801093923,0.000208876564249226,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00139251042832817
+"KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.116533333333333,1.13235714120506,0.23924678852022,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.374473234205562
+"KEGG_HISTIDINE_METABOLISM",-0.116866666666667,1.38316515214028,0.00189511352797835,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC15, H1299, H520",0.00741566163121962
+"KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.1172,1.40260860032808,0.0009363483501256,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, H358, HCC15",0.0042135675755652
+"KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.123733333333333,1.42138320291321,0.000403536004808347,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.00213091037398761
+"KEGG_OOCYTE_MEIOSIS",-0.133533333333333,1.00423537840394,0.704540767861799,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.84008352030222
+"KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.134866666666667,1.23720034563449,0.0551572381005017,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.124103785726129
+"KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.1436,1.15758441839647,0.191255446117642,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.315834681662162
+"KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.1442,1.09261712023406,0.318078952500197,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.458033691600284
+"KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.144533333333333,1.07241655464034,0.48540261925761,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.639137812907459
+"KEGG_PANCREATIC_CANCER",-0.146666666666667,0.934790248945617,0.924617650695373,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_GLUTATHIONE_METABOLISM",-0.158866666666667,1.31317814408223,0.0101778052018162,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0295484667149502
+"KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.1628,1.21792699757768,0.0685664310635586,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.150511677944397
+"KEGG_PATHWAYS_IN_CANCER",-0.180066666666667,0.90808680096962,0.957106780963963,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_ENDOCYTOSIS",-0.1846,1.00630787677387,0.729025288211259,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.861108689845029
+"KEGG_MAPK_SIGNALING_PATHWAY",-0.187066666666667,0.921563304287624,0.934570451523719,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_TYROSINE_METABOLISM",-0.192,1.50827811001249,5.65978375031642e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.000407504430022782
+"KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.192133333333333,1.04184663435834,0.518489098477848,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.671424731841818
+"KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.196933333333333,0.960552628636741,0.83185108990271,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.94744276237978
+"KEGG_OLFACTORY_TRANSDUCTION",-0.198733333333333,1.18631268262309,0.11012697044799,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.217734061607094
+"KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.199666666666667,1.10651387356009,0.317362301632942,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.458033691600284
+"KEGG_RENAL_CELL_CARCINOMA",-0.219733333333333,0.900459602224384,0.94635264703455,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.2246,1.67563181260937,4.42095301296459e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2126, H1299, H1703, H520",3.97885771166813e-05
+"KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.229733333333333,1.44143195006447,0.000267302268531937,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H358",0.00155207768824996
+"KEGG_BLADDER_CANCER",-0.2308,1.19553575557452,0.0775227534351468,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.162256925794493
+"KEGG_WNT_SIGNALING_PATHWAY",-0.232,0.886887253262781,0.967840805462783,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_PROPANOATE_METABOLISM",-0.236733333333333,1.24271255535546,0.0146935009650931,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",0.0391644131755798
+"KEGG_CELL_CYCLE",-0.2402,0.908414490039809,0.939769760564196,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_ENDOMETRIAL_CANCER",-0.2454,1.09995167426314,0.245450588127686,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.380871602267099
+"KEGG_P53_SIGNALING_PATHWAY",-0.245933333333333,1.07180731654973,0.377073203335263,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.534434461420058
+"KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.252,1.12798188941895,0.221805649577764,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.353318733840686
+"KEGG_RETINOL_METABOLISM",-0.2554,1.44856489573055,0.000130277909206758,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.000901923986816018
+"KEGG_VIBRIO_CHOLERAE_INFECTION",-0.255733333333333,1.10063679403378,0.272683022649791,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.413373291151073
+"KEGG_VEGF_SIGNALING_PATHWAY",-0.2568,1.15866457613927,0.130985801712934,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.242409808081716
+"KEGG_AXON_GUIDANCE",-0.257666666666667,1.13278529466511,0.180491036637241,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.30649421315758
+"KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.267333333333333,1.05991580977431,0.405071546074489,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.565216110801613
+"KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.28,1.87513047165105,3.18385886523285e-10,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H358, HCC44, H1299, H1703",5.73094595741913e-08
+"KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.286666666666667,1.5820360600309,8.78931768647305e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC15, H1299, H520",1.21698244889627e-05
+"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.299066666666667,1.29070769439907,0.00644130882772217,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H358",0.0214710294257406
+"KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.304466666666667,1.0126025074506,0.574692748461573,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.733650317184986
+"KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.337133333333333,1.34641231567805,0.00194327654864967,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00744233571823277
+"KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.337733333333333,1.36035181723945,0.00125522888097129,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H358",0.00526757774994115
+"KEGG_MELANOGENESIS",-0.3606,1.01565347015041,0.479263347284429,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.639017796379239
+"KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.367066666666667,1.59104078544592,4.09838288172268e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H358",6.7064447155462e-06
+"KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.374533333333333,0.909342059377208,0.836907773435473,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.94744276237978
+"KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.377066666666667,1.22405482292412,0.0300099902625001,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.071076292726974
+"KEGG_BUTANOATE_METABOLISM",-0.377266666666667,1.25245264904316,0.0126448660771294,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0349184562193333
+"KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.3778,1.27906105070422,0.00953831726644881,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0286149517993464
+"KEGG_SULFUR_METABOLISM",-0.381428571428571,2.06189180176793,1.17983138427951e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,7,"HCC95, H1650, H2126, H358, HCC15, HCC44, H1299",8.84873538209632e-05
+"KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.384533333333333,1.12226192936196,0.111286298154737,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.217734061607094
+"KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.386933333333333,1.07367383093661,0.217682213026563,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.34984641379269
+"KEGG_THYROID_CANCER",-0.391533333333333,1.25893463274461,0.00802769018660458,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0247804492894448
+"KEGG_INSULIN_SIGNALING_PATHWAY",-0.395666666666667,0.874851878619352,0.88238111571935,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.980423461910389
+"KEGG_TYPE_II_DIABETES_MELLITUS",-0.400133333333333,1.23535610057914,0.0167035201414305,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0435744003689491
+"KEGG_MELANOMA",-0.413466666666667,1.08474077658257,0.168905974345538,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.295175489147542
+"KEGG_ERBB_SIGNALING_PATHWAY",-0.4184,0.910869741353991,0.731942386368275,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.861108689845029
+"KEGG_MTOR_SIGNALING_PATHWAY",-0.424733333333333,1.09238346659735,0.131978673288934,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.242409808081716
+"KEGG_COLORECTAL_CANCER",-0.433533333333333,0.772008777398905,0.983006312437232,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.999504660123495
+"KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.4388,0.920364151533822,0.704736730920196,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.84008352030222
+"KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.451466666666667,0.921761114595833,0.702468913866307,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.84008352030222
+"KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.457533333333333,0.922972748914124,0.660327274567269,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.808564009674207
+"KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.462266666666667,0.970501451140938,0.469990496739128,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.631330518007783
+"KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.49,1.21759452551801,0.00738525001672431,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0233218421580768
+"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.495,1.78343553505371,2.27077817176701e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,6,"H1650, H2009, H2126, H1299, H1703, H520",8.17480141836125e-07
+"KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.496,1.97662085388169,0.00125836579581927,"H1975, H3255, H358, A549, H1299",5,2,"H1975, H1299",0.00526757774994115
+"KEGG_PROSTATE_CANCER",-0.5206,0.902667934514127,0.614827059755361,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.763233591420448
+"KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.526333333333333,0.983546474075662,0.273285675816543,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.413373291151073
+"KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.5286,0.894814489952287,0.622747961979733,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.767771459975013
+"KEGG_GLIOMA",-0.538066666666667,0.952737594413868,0.389356790454249,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.547532986576288
+"KEGG_GALACTOSE_METABOLISM",-0.541,1.02375631866182,0.163081745998481,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.287791316467907
+"KEGG_PRION_DISEASES",-0.547,1.18303984958846,0.0207580110402963,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H460",0.0511841368116894
+"KEGG_ACUTE_MYELOID_LEUKEMIA",-0.549133333333333,0.912179874700995,0.54362039262065,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.698940504797978
+"KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.5544,0.85538001579916,0.691663425614035,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.84008352030222
+"KEGG_REGULATION_OF_AUTOPHAGY",-0.570733333333333,1.22561252713354,0.00725414015872706,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H358",0.0233168790816227
+"KEGG_PPAR_SIGNALING_PATHWAY",-0.5758,1.12656780913154,0.0222274511862465,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0540667731557348
+"KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.5894,0.991905223007003,0.199551796192625,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.326539302860658
+"KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.6172,0.923371632349928,0.306708127863984,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.452812740124564
+"KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.646866666666667,0.895843725742599,0.346648937356579,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.495212767652256
+"KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.655533333333333,1.01025003034374,0.117222225311158,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.223680268416371
+"KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.6778,0.827376162507547,0.429927334736064,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.59073984925566
+"KEGG_NITROGEN_METABOLISM",-0.682,1.37821416540184,6.34573847655268e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, HCC44",5.1910931146388e-05
+"KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.717866666666667,0.933048220057453,0.121665004380268,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.228121883213003
+"KEGG_STEROID_BIOSYNTHESIS",-0.731333333333333,1.57573958447938,9.04268113610231e-10,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H2009, H2126, H3255, H1299, H1703",8.13841302249208e-08
+"KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.824571428571429,1.50016864253455,9.62880005554781e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",14,4,"HCC95, H358, HCC15, H1299",2.88864001666434e-06
+"KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.8725,1.52090956637497,1.59394812683833e-06,"HCC827, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H520",12,3,"H1975, H358, H520",1.88788954214348e-05
+"KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.992266666666667,1.21141590514492,2.42902792930391e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H358, H1299",2.30118435407739e-05
+"KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-1.0094,1.28993841491976,4.08662823976643e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"H2126, H358, A549, HCC44",6.7064447155462e-06
+"KEGG_LINOLEIC_ACID_METABOLISM",-1.0175,1.60813297543041,0.0521757312240981,"H1975, H3255, H358, H1299",4,1,"H1299",0.118881412915667
+"KEGG_FOLATE_BIOSYNTHESIS",-1.05066666666667,1.4263162676062,1.59840417740477e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"HCC95, H1650, H358, H1299, H1703",7.19281879832146e-07
+"KEGG_TYPE_I_DIABETES_MELLITUS",-1.74,NA,NA,"HCC15",1,0,"",NA
diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..3228315
--- /dev/null
+++ b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_results.csv
@@ -0,0 +1,2659 @@
+"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"HCC827","Input","KEGG_ABC_TRANSPORTERS",0.54049,1.52,0.0709,1185,0.401,"ABCA12, ABCC3, ABCC2, ABCA3, ABCG2, ABCB7, ABCD3, TAP2",1.14935376481693,0.396855627379818,FALSE
+"HCC827","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.39562,-1.23,0.188,5858,0.594,"RELA, BRAF, STAT5A, BAD, SOS1, CCND1, IKBKG, RPS6KB2, MAP2K1, MTOR, AKT1, CHUK, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, RPS6KB1, TCF7L1, AKT2, MAPK1, PIK3CB",0.72584215073632,0.226213555018806,FALSE
+"HCC827","Input","KEGG_ADHERENS_JUNCTION",0.43356,1.23,0.187,1419,0.615,"EGFR, CDH1, CTNNB1, CTNND1, RAC2, TGFBR2, CTNNA1, CTNNA2, MET, LMO7, TJP1, PTPRF, PTPRJ, AFDN, RAC3, PARD3, SRC, NECTIN4",0.728158393463501,0.211124884224583,FALSE
+"HCC827","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.38221,-1.13,0.294,5467,0.63,"STAT3, PTPN11, PRKAA1, PRKAG1, RELA, RXRG, ACACB, ADIPOR2, PRKCQ, IKBKG, ACSL1, MTOR, STK11, MAPK8, AKT1, NFKBIB, CHUK, AKT3, IKBKB, MAPK9, IRS2, AKT2, CPT1A",0.531652669587843,0.200659450546418,FALSE
+"HCC827","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.30791,-0.902,0.524,6277,0.771,"ASS1, ADSL, ASL, CAD, PPAT, CPS1, NIT2, GLUD2",0.280668713016273,0.112945621949043,FALSE
+"HCC827","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.26484,-0.779,0.693,7350,0.829,"MAPK3, IRS2, MAPK1, PIK3CB, ATP1B3",0.159266765388193,0.0814454694497265,FALSE
+"HCC827","Input","KEGG_ALZHEIMERS_DISEASE",-0.24201,-0.73,0.779,6859,0.856,"NDUFS5, NDUFB3, NAE1, NDUFA6, ITPR2, NDUFA9, CASP3, NDUFB4, CAPN1, NDUFV3, MAPK3, NDUFS7, NDUFA2, IDE, GSK3B, NDUFB7, CASP9, MAPK1, ITPR1, ATP2A1, PSEN2, ATP2A3, MAPT, SNCA, MME, BID",0.108462542327436,0.0675262353228468,FALSE
+"HCC827","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.3628,1.03,0.386,1945,0.687,"PARS2, MARS2, TARS2, AARS2, YARS2, WARS2, FARS2",0.413412695328245,0.16304326294045,FALSE
+"HCC827","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.39724,-1.2,0.254,7420,0.615,"UAP1, GALK1, NPL, GNPDA2, HK3, PGM3, GCK, GNE",0.595166283380062,0.211124884224583,FALSE
+"HCC827","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.59984,-1.84,0.0285,7111,0.433,"CASP3, ALS2, MAPK14, BCL2L1, BAX, SOD1, CASP9, NEFL, NEFM, PRPH, PRPH2, NEFH, BID",1.54515513999149,0.363512103646635,FALSE
+"HCC827","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.48545,1.37,0.126,1185,0.493,"CTSS, B2M, IFI30, LGMN, TAPBP, CREB1, PSME2, TAP2",0.899629454882437,0.30715308072277,FALSE
+"HCC827","Input","KEGG_APOPTOSIS",-0.27932,-0.855,0.603,5858,0.765,"RELA, ATM, PRKACB, BIRC2, BAD, RIPK1, APAF1, IKBKG, IRAK4, PRKAR2B, PRKAR1A, DFFB, AKT1, CHUK, CASP3, XIAP, CAPN1, TNFRSF10D, BCL2L1, AKT3, BAX, IKBKB, AKT2, CASP9, PIK3CB, BID",0.219682687859849,0.116338564846382,FALSE
+"HCC827","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.62342,1.76,0.0292,1027,0.762,"PTGS2, PTGES, GGT7, EPHX2, ALOX5, GGT1, GPX6, GPX7, PLA2G12A",1.53461714855158,0.1180450286604,FALSE
+"HCC827","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34364,0.991,0.426,796,0.753,"PRODH, PRODH2, OAT, GATM, AGMAT, ALDH1B1, LAP3",0.370590400897281,0.123205023799299,FALSE
+"HCC827","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.60072,1.71,0.0381,545,0.472,"ITGB6, ITGA1, DSC2, ITGA3, ITGA2, ITGA5, DSG2, CTNNB1, ITGB1, CTNNA1, GJA1, CTNNA2, ITGAV",1.41907502432438,0.326058001365912,FALSE
+"HCC827","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.52864,1.47,0.0989,786,0.429,"UGDH, ALDH1B1",1.00480370840282,0.367542707815276,FALSE
+"HCC827","Input","KEGG_AXON_GUIDANCE",0.4022,1.13,0.288,1664,0.658,"EPHB2, SEMA4B, ITGB1, RAC2, NRP1, EPHA1, EFNA5, EFNB2, MET, CFL2, SEMA3A, CXCR4, EFNA1, PLXNB3, PLXNB2, RAC3, PLXNB1, GNAI1, GNAI3, ROBO1, SLIT1, SLIT3, GNAI2, KRAS, NRAS, NTN4",0.540607512240769,0.181774106386044,FALSE
+"HCC827","Input","KEGG_BASAL_CELL_CARCINOMA",0.42377,1.22,0.196,338,0.614,"CTNNB1, TP53",0.707743928643524,0.211831628858832,FALSE
+"HCC827","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.24193,-0.735,0.787,4917,0.868,"TAF6, GTF2A1, TAF6L, TAF1, GTF2F1, TAF10, GTF2H2, TAF12, GTF2H4, GTF2H1, GTF2F2, GTF2IRD1, TAF2, TBPL1",0.104025267640935,0.0614802748235081,FALSE
+"HCC827","Input","KEGG_BASE_EXCISION_REPAIR",-0.37347,-1.09,0.304,6755,0.621,"MUTYH, LIG3, NTHL1, PARP1, FEN1, HMGB1, MPG",0.517126416391246,0.20690839982342,FALSE
+"HCC827","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29755,-0.899,0.535,6702,0.766,"ALDH7A1, ALDH2, SRM, EHHADH",0.271646217978772,0.115771230367396,FALSE
+"HCC827","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.2539,0.723,0.799,2400,0.972,"ACOX3, SCD5, PECR, ACAA1, FADS1, ELOVL6, ACOT2, HADHA, ACOX1",0.0974532206860086,0.0123337350737254,FALSE
+"HCC827","Input","KEGG_BLADDER_CANCER",0.4753,1.35,0.135,338,0.503,"CDKN2A, EGFR, CDH1, CDK4, TP53",0.869666231504994,0.298432014944073,FALSE
+"HCC827","Input","KEGG_BUTANOATE_METABOLISM",0.36724,1.04,0.37,786,0.682,"ACSM3, ACADS, HMGCL, BDH2, ALDH1B1",0.431798275933005,0.166215625343521,FALSE
+"HCC827","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.286,-0.869,0.612,6577,0.759,"MAP2K1, BLNK, NFAT5, AKT1, SYK, NFKBIB, CHUK, CD22, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, AKT2, MAPK1, PIK3CB, CD81, PLCG2",0.213248577854439,0.11975822410452,FALSE
+"HCC827","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.23319,0.669,0.878,615,0.969,"TNNC1, EGFR, PLCB4, P2RX4, CAMK2D, ERBB3",0.0565054840938974,0.0136762229492347,FALSE
+"HCC827","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.45321,1.29,0.157,2323,0.544,"TNNC1, COX6A1, COX7A2, COX7C, COX5B, COX5A, UQCRH, COX6B1, COX6C, COX7A2L, ATP2A2, COX4I1, SLC9A6, UQCRFS1, COX7B, UQCRB, ATP1B1, UQCRC2, UQCRC1",0.804100347590766,0.26440110030182,FALSE
+"HCC827","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.39319,1.15,0.272,592,0.636,"ITGB2, CDH1, CDH15, CDH3, OCLN, CLDN6, CD274, CLDN3, CLDN4, ICAM1, ALCAM, ITGB1, F11R, SDC1, ITGAV, CD276, CNTN1",0.565431095965801,0.196542884351586,FALSE
+"HCC827","Input","KEGG_CELL_CYCLE",0.25369,0.726,0.808,926,0.981,"CDKN2A, FZR1, CDK4, TP53, ZBTB17, TFDP2, TGFB2, E2F3, CDC20, CCNA2, CCNB1",0.0925886392254138,0.0083309926200515,FALSE
+"HCC827","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.29394,0.84,0.639,1649,0.862,"CXCL5, CX3CL1, PLCB4, RAC2, LYN, GNG12, STAT1, GNG4, ARRB1, CXCR4, GNB3, GNAI1, PIK3R3, STAT2, GNAI3, GNB2, PARD3, PRKCB, RAP1A, GNAI2, KRAS, NRAS, ADCY9",0.1944991418416,0.0644927341752872,FALSE
+"HCC827","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.26282,0.746,0.776,704,0.974,"CDKN2A, CDK4, TGFBR2, TP53, TGFB2, E2F3",0.110138278741812,0.0114410431213845,FALSE
+"HCC827","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.36444,1.04,0.369,2236,0.682,"DLST, DLAT, SUCLG2, SDHC, OGDHL, PDHB, PDHA1, OGDH, SUCLG1, CS, MDH2, SDHA, SDHB",0.43297363384094,0.166215625343521,FALSE
+"HCC827","Input","KEGG_COLORECTAL_CANCER",-0.25449,-0.758,0.752,6269,0.848,"MSH2, CCND1, APPL1, MAP2K1, SMAD4, MAPK8, AKT1, MSH6, SMAD2, CASP3, MAPK3, RAF1, AKT3, BAX, GSK3B, MAPK9, TCF7L1, AKT2, CASP9, MAPK1, PIK3CB",0.123782159408358,0.0716041477432862,FALSE
+"HCC827","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.59971,1.71,0.0294,706,0.472,"CFB, SERPINA1, CFI, MBL2, SERPINC1, PROS1, PLAU, TFPI, SERPINF2, F3, F8",1.53165266958784,0.326058001365912,FALSE
+"HCC827","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.27524,-0.815,0.658,7177,0.792,"SRM, MAT1A, AHCY, SDS, APIP",0.181774106386044,0.101274818410506,FALSE
+"HCC827","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.52324,1.49,0.0855,993,0.423,"CXCL5, EGFR, CX3CL1, TGFBR2, TNFRSF10B, IL6ST, IL10RB, OSMR, MET, TNFRSF10A, LTBR, IL18, TGFB2, CXCR4, TNFRSF21, IL1RAP",1.06803388527183,0.373659632624958,FALSE
+"HCC827","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.25404,-0.762,0.729,5858,0.85,"RELA, POLR3A, POLR3B, IRF3, RIPK1, POLR3D, IKBKG, NFKBIB, CHUK, TREX1, POLR3C, IKBKB, PYCARD",0.137272471682025,0.0705810742857073,FALSE
+"HCC827","Input","KEGG_DILATED_CARDIOMYOPATHY",0.51379,1.45,0.0924,660,0.436,"ITGB6, TNNC1, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, ITGAV, TGFB2",1.03432802877989,0.360513510731414,FALSE
+"HCC827","Input","KEGG_DNA_REPLICATION",-0.22458,-0.659,0.883,5811,0.942,"POLA2, MCM7, MCM2, PRIM1, RNASEH2A, PRIM2, RNASEH1, FEN1, RNASEH2C, RNASEH2B",0.0540392964224314,0.0259490972071227,FALSE
+"HCC827","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.5855,1.71,0.0304,412,0.472,"EGFR, ETS2, ETS1, ETV6",1.51712641639125,0.326058001365912,FALSE
+"HCC827","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.35448,-1.07,0.32,7065,0.631,"MGST2, GSTM2, GSTO1, GSTA4, ALDH3A1, GSTT2, GSTM4, MAOA, GSTM3, MAOB",0.494850021680094,0.199970640755866,FALSE
+"HCC827","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.32803,-0.966,0.449,6831,0.69,"UMPS, GMPS, IMPDH1, CES1, CES2, TPMT, UCK2",0.347753658996677,0.161150909262745,FALSE
+"HCC827","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.58515,1.67,0.0377,1235,0.302,"ITGB6, TNC, ITGA1, LAMB3, ITGA3, ITGA2, LAMC2, ITGA5, ITGB1, CD47, SDC1, ITGAV, LAMB1, ITGA6, SDC4, LAMA5, COL5A1, AGRN",1.42365864979421,0.519993057042849,FALSE
+"HCC827","Input","KEGG_ENDOCYTOSIS",0.22512,0.644,0.907,1759,0.96,"EGFR, RAB11FIP1, RAB31, EPN3, EPN2, MET, ERBB3, RAB11A, ACAP1, ARRB1, CXCR4, RAB11B, EHD1, RAB11FIP5, STAM2, PLD2, PARD3, RAB5B, PSD, SRC, LDLR, CHMP2B, EHD4, PLD1, EHD3, CLTA, AGAP1, RAB22A, RUFY1, RAB5A",0.0423927129399047,0.0177287669604316,FALSE
+"HCC827","Input","KEGG_ENDOMETRIAL_CANCER",0.38834,1.12,0.29,425,0.644,"EGFR, CDH1, CTNNB1, TP53, CTNNA1, CTNNA2",0.537602002101044,0.191114132640188,FALSE
+"HCC827","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.26233,0.751,0.792,810,0.98,"EGFR, LYN, F11R, JUN, MET, TCIRG1, TJP1, ADAM17",0.101274818410506,0.00877392430750515,FALSE
+"HCC827","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.28031,-0.831,0.617,5895,0.783,"BRAF, PAK3, STAT5A, NCK2, PTK2, CRK, BAD, CAMK2G, SOS1, NCK1, RPS6KB2, HBEGF, MAP2K1, MTOR, MAPK8, CBL, AKT1, SHC1, PLCG1, ABL2, MAPK3, RAF1, MAP2K2, AKT3, GSK3B, MAPK9, RPS6KB1, AKT2, MAPK1, CRKL, PIK3CB, PLCG2",0.209714835966758,0.106238237942057,FALSE
+"HCC827","Input","KEGG_ETHER_LIPID_METABOLISM",0.58793,1.7,0.0258,1722,0.37,"LPCAT1, PLPP2, PLPP1, PAFAH2, PLA2G12A, PLD2, LPCAT4, PLD1, PLPP3, AGPS",1.58838029403677,0.431798275933005,FALSE
+"HCC827","Input","KEGG_FATTY_ACID_METABOLISM",0.30824,0.894,0.552,1362,0.823,"ACADS, ACSL4, CPT2, ACADVL, ALDH1B1, ACOX3, ACAA1, ACADM",0.258060922270801,0.0846001647877302,FALSE
+"HCC827","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34275,-1.02,0.393,6577,0.66,"MAP2K1, MAPK8, AKT1, SYK, PLCG1, PRKCD, MAPK14, MAPK3, RAF1, MAP2K2, AKT3, MAPK9, AKT2, MAPK1, PIK3CB, PLCG2",0.405607449624573,0.180456064458131,FALSE
+"HCC827","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.2418,0.692,0.85,552,0.978,"MARCKS, PLPP2, RAC2, LYN, MARCKSL1, AMPH, PLPP1, CFL2",0.0705810742857073,0.00966114521239857,FALSE
+"HCC827","Input","KEGG_FOCAL_ADHESION",0.33014,0.941,0.498,545,0.815,"ITGB6, TNC, EGFR, ITGA1, LAMB3, ITGA3, ITGA2, LAMC2, ITGA5, CTNNB1, ITGB1, RAC2, JUN, MET, ITGAV",0.302770657240282,0.0888423912600234,FALSE
+"HCC827","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.61361,-1.81,0.031,6548,0.42,"ALPI, ALPP, GGH, DHFR",1.50863830616573,0.3767507096021,FALSE
+"HCC827","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.49287,-1.41,0.122,6011,0.416,"GMDS, ALDOA, PMM1, PFKFB4, ALDOC, PMM2, PFKL, PFKM, PFKFB3, MTMR6, PFKP, MTMR2, AKR1B1, HK3",0.913640169325252,0.380906669373257,FALSE
+"HCC827","Input","KEGG_GALACTOSE_METABOLISM",-0.40012,-1.21,0.227,7624,0.614,"GALK1, PFKP, AKR1B1, HK3, GCK",0.643974142806877,0.211831628858832,FALSE
+"HCC827","Input","KEGG_GAP_JUNCTION",-0.29238,-0.872,0.554,6779,0.763,"CDK1, ADCY5, ADCY6, ITPR2, CSNK1D, TUBA1B, TUBB1, TUBA3C, TUBB, MAPK3, RAF1, TUBB2A, MAP2K2, TUBB6, TUBAL3, MAPK1, ITPR1, TUBB2B",0.25649023527157,0.11747546204512,FALSE
+"HCC827","Input","KEGG_GLIOMA",0.31413,0.893,0.542,704,0.811,"CDKN2A, EGFR, CDK4, TP53, CAMK2D, E2F3",0.266000713461613,0.090979145788844,FALSE
+"HCC827","Input","KEGG_GLUTATHIONE_METABOLISM",-0.37778,-1.13,0.279,6961,0.63,"GGCT, MGST2, GSTM2, SRM, PGD, GSTO1, GSTA4, IDH2, RRM2B, GCLM, ANPEP, RRM2, RRM1, GSTT2, GSTM4, GSTM3",0.554395796726402,0.200659450546418,FALSE
+"HCC827","Input","KEGG_GLYCEROLIPID_METABOLISM",0.38497,1.11,0.317,1248,0.648,"LPL, PLPP2, MGLL, PLPP1, ALDH1B1, GLA, GPAT3, MBOAT2, MBOAT1",0.498940737782249,0.188424994129407,FALSE
+"HCC827","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33079,0.935,0.501,1567,0.812,"LPCAT1, PEMT, PLPP2, PLPP1, GPD2, GPAT3, PLA2G12A, CDS1, PLD2, LPCAT4, MBOAT2, MBOAT1, PISD, PLD1, PLPP3",0.300162274132754,0.0904439707588247,FALSE
+"HCC827","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.33729,-0.995,0.398,7312,0.693,"PHGDH, SDS, GCAT, MAOA, MAOB",0.400116927926312,0.159266765388193,FALSE
+"HCC827","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.27023,-0.815,0.678,6478,0.792,"ALDOC, BPGM, GPI, PFKL, ALDH7A1, ALDH2, PKLR, PFKM, PKM, PFKP, ACSS2, HK3, ALDH3A1, ACSS1, GCK",0.168770306132937,0.101274818410506,FALSE
+"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.6485,-1.93,0.0252,7319,0.892,"CHST14, CHPF, CHST12",1.59859945921846,0.0496351456238769,FALSE
+"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.31616,-0.967,0.458,5041,0.699,"HS3ST1, EXT1, B3GALT6, EXTL2, EXT2, GLCE",0.339134521996131,0.155522824254319,FALSE
+"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.40808,-1.24,0.201,6954,0.595,"B3GNT2, B4GAT1, B4GALT4, ST3GAL1",0.696803942579511,0.22548303427145,FALSE
+"HCC827","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.63815,1.78,0.0317,1502,1,"GNS, HPSE, IDS, HEXB, SGSH, HEXA",1.49894073778225,0,FALSE
+"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.3095,-0.916,0.487,7834,0.766,"ST3GAL1",0.312471038785366,0.115771230367396,FALSE
+"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.59506,1.69,0.0325,1502,0.307,"B3GALT5, GLA, HEXB, HEXA",1.48811663902113,0.512861624522813,FALSE
+"HCC827","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.44013,-1.28,0.191,6954,0.561,"B3GNT2, B4GAT1, B4GALT4, FUT3, ST3GAL4",0.718966632752272,0.251037138743839,FALSE
+"HCC827","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.64256,-1.94,0.0179,7997,1,"PGAP1, PIGM, PIGX",1.74714696902011,0,FALSE
+"HCC827","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.25109,-0.747,0.755,2075,0.857,"CS, MDH2, MTHFD1L, MTHFD1, ACO2, MTHFD2, ACO1, PGP, MDH1, GRHPR",0.122053048370812,0.0670191780768018,FALSE
+"HCC827","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.22789,0.658,0.901,1649,0.957,"EGFR, PLCB4, JUN, CAMK2D, GNAQ, PLA2G12A, PLD2, MAP2K4, PRKCB, ITPR3, SRC, PLD1, KRAS, NRAS, ADCY9",0.045275209020937,0.0190880622231565,FALSE
+"HCC827","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.24669,0.698,0.865,929,0.997,"CSNK1G1, LRP2",0.0629838925351858,0.00130484168834428,FALSE
+"HCC827","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.42532,1.21,0.197,201,0.613,"ITGA1, ITGA3, ITGA2, ITGA5",0.705533773838407,0.212539525481585,FALSE
+"HCC827","Input","KEGG_HISTIDINE_METABOLISM",-0.49187,-1.49,0.0806,7840,0.383,"METTL2B, ALDH3A1, BUD23, LCMT1, MAOA, MAOB",1.09366495819491,0.416801226031377,FALSE
+"HCC827","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.20486,-0.607,0.948,6866,0.976,"BLM, TOP3B, MUS81",0.0231916626619338,0.0105501823333082,FALSE
+"HCC827","Input","KEGG_HUNTINGTONS_DISEASE",0.23112,0.658,0.901,2330,0.957,"PLCB4, SOD2, COX6A1, TP53, COX7A2, CREB1, COX7C, ATP5PF, COX5B, COX5A, GNAQ, UQCRH, COX6B1, NDUFB1, DLG4, COX6C, COX7A2L, ATP5MC2, RCOR1, COX4I1, HTT, NDUFB10, CLTA, SDHC, POLR2D, SLC25A5, SLC25A31, UQCRFS1, CREB5, GPX1, CASP8, POLR2K, COX7B, TFAM, POLR2L, UQCRB, AP2B1, SDHA, SDHB, TAF4, UQCRC2, UQCRC1, CLTB",0.045275209020937,0.0190880622231565,FALSE
+"HCC827","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.53826,1.54,0.0722,660,0.43,"ITGB6, TNNC1, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, ACE, ITGAV, TGFB2",1.14146280243036,0.366531544420413,FALSE
+"HCC827","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.37439,-1.09,0.323,7479,0.621,"CDIPT, PLCD3, PIP5K1A, OCRL, IMPA2, ITPKB, PIK3CB, ITPK1, PLCG2, ITPKA",0.490797477668897,0.20690839982342,FALSE
+"HCC827","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.39484,-1.17,0.279,5975,0.602,"TSC1, ACACB, PRKACB, EIF4E2, CRK, PHKG2, BAD, ACACA, INPP5D, PRKCI, SOS1, RPS6KB2, MAP2K1, PRKAR2B, MTOR, MAPK8, PRKAR1A, PHKB, CBL, AKT1, SHC1, PKLR, GYS1, RPTOR, MAPK3, RAF1, PPP1R3D, MAP2K2, AKT3, IKBKB, GSK3B, MAPK9, RPS6KB1, IRS2, AKT2, MAPK1, CRKL, PIK3CB, HK3, SORBS1, GCK",0.554395796726402,0.220403508742175,FALSE
+"HCC827","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.5027,-1.53,0.0963,8256,0.387,"CD40",1.01637371287547,0.412289034981089,FALSE
+"HCC827","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.25171,0.732,0.828,1605,0.985,"IRF9, IL6ST, STAT1, IL10RB, OSMR, STAM2, PIK3R3, STAT2, JAK1, IFNGR1, SPRY1, IL13RA1",0.0819696632151199,0.00656376950238827,FALSE
+"HCC827","Input","KEGG_LEISHMANIA_INFECTION",0.59025,1.69,0.0353,1357,0.307,"PTGS2, ITGB2, ITGB1, MARCKSL1, JUN, STAT1, CYBA, TGFB2, NCF2, JAK1, PRKCB, IFNGR1",1.45222529461218,0.512861624522813,FALSE
+"HCC827","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.37798,1.07,0.367,434,0.682,"ITGB2, OCLN, CLDN6, CLDN3, CLDN4, ICAM1, CTNNB1, CTNND1, ITGB1, RAC2, F11R, CTNNA1, CTNNA2, CYBA",0.435333935747911,0.166215625343521,FALSE
+"HCC827","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.46478,-1.37,0.139,6702,0.453,"ALDH7A1, ALDH2, EHHADH",0.856985199745905,0.343901797987168,FALSE
+"HCC827","Input","KEGG_LONG_TERM_DEPRESSION",0.28927,0.807,0.674,1585,0.915,"PLCB4, LYN, GNAQ, PLA2G12A, GNAI1, GNAI3, PRKCB, ITPR3, GNAI2, KRAS, NRAS",0.17134010346468,0.0385789059335517,FALSE
+"HCC827","Input","KEGG_LONG_TERM_POTENTIATION",-0.17933,-0.545,0.987,6899,0.992,"RPS6KA1, ITPR2, MAPK3, RAF1, MAP2K2, MAPK1, ITPR1, CAMK4",0.00568284733036327,0.00348832784582135,FALSE
+"HCC827","Input","KEGG_LYSINE_DEGRADATION",0.2399,0.683,0.857,2365,0.977,"TMLHE, PLOD2, DLST, PIPOX, ALDH1B1, SETDB1, EHMT1, SETD2, EHMT2, SETD1B, GCDH, OGDHL, OGDH, SETD1A, ECHS1, HADH, HADHA",0.0670191780768018,0.0101054362812269,FALSE
+"HCC827","Input","KEGG_LYSOSOME",0.53598,1.53,0.0749,1582,0.415,"GNS, CTSS, NAPSA, CTSK, CTSO, CTSH, CTSC, AP1M2, IDS, NPC2, FUCA1, LGMN, GAA, AGA, SUMF1, CTSV, AP1B1, TCIRG1, AP1S1, GLA, AP1S3, GALC, PSAP, HEXB, CLN5, IGF2R, LAMP2, GGA3, CD63, ASAH1, SCARB2, M6PR, SGSH, HEXA, AP1G1, LAMP1",1.12551818230053,0.381951903287907,FALSE
+"HCC827","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.26069,-0.793,0.702,7088,0.814,"RPS6KA5, CASP3, RELB, NFKB2, MAPK14, MAPKAPK2, MAPK3, RASA1, CD14, TAOK2, RAF1, FLNA, MAP3K11, PPP5C, MAP2K2, AKT3, IKBKB, MAPK9, STK4, AKT2, NLK, MAPK1, CRKL, HSPA2, HSPA1L, STMN1, FGFR1, MAPT, FLNB",0.153662887870195,0.0893755951107988,FALSE
+"HCC827","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.63536,-1.9,0.0285,6310,0.504,"IAPP, PKLR, MNX1, GCK",1.54515513999149,0.297569463554475,FALSE
+"HCC827","Input","KEGG_MELANOGENESIS",0.23385,0.671,0.872,1649,0.979,"CTNNB1, PLCB4, CAMK2D, CREB1, GNAQ, GNAI1, GNAI3, ASIP, PRKCB, GNAI2, KRAS, NRAS, ADCY9",0.0594835150674328,0.00921730819686218,FALSE
+"HCC827","Input","KEGG_MELANOMA",0.40989,1.17,0.237,704,0.674,"CDKN2A, EGFR, CDH1, CDK4, TP53, MET, E2F3",0.625251653989896,0.17134010346468,FALSE
+"HCC827","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.35663,-1.05,0.407,7065,0.63,"MGST2, GSTM2, GSTO1, GSTA4, AKR1C3, AKR1C1, ALDH3A1, GSTT2, GSTM4, GSTM3",0.39040559077478,0.200659450546418,FALSE
+"HCC827","Input","KEGG_MISMATCH_REPAIR",-0.18696,-0.55,0.977,1543,1,"POLD4, SSBP1, RFC1, POLD3, RFC4, LIG1, RFC5, POLD2, POLD1, RFC2, MSH3, RFC3, RPA2, RPA1, PCNA, PMS2, RPA3, MLH3, MLH1, MSH2, MSH6",0.0101054362812269,0,FALSE
+"HCC827","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.4814,-1.45,0.0955,5510,0.414,"PRKAA1, RHEB, MLST8, TSC2, RPS6, BRAF, TSC1, EIF4E2, RPS6KB2, MTOR, STK11, AKT1, RPS6KA1, RICTOR, RPTOR, MAPK3, AKT3, RPS6KB1, AKT2, MAPK1, PIK3CB",1.01999662841625,0.382999658879101,FALSE
+"HCC827","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.27935,-0.878,0.58,7315,0.773,"TNFRSF10D, MAPK3, IFNAR1, RAF1, MAP2K2, MAPK1, PIK3CB, PRF1, ZAP70, BID, PLCG2",0.236572006437063,0.111820506081675,FALSE
+"HCC827","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.31793,0.898,0.571,538,0.829,"P2RX4, CHRNE",0.243363891754152,0.0814454694497265,FALSE
+"HCC827","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.38899,-1.15,0.262,6253,0.624,"MAP3K3, CAMK2G, SOS1, MAGED1, IRAK4, MAP2K1, MAP3K5, MAPK8, AKT1, SHC1, PLCG1, NFKBIB, RPS6KA1, PRKCD, RPS6KA5, ARHGDIA, MAPK14, MAPKAPK2, MAPK3, RAF1, MAP2K2, AKT3, BAX, IKBKB, GSK3B, MAPK9, IRS2, AKT2, MAPK1, CRKL, PIK3CB, CSK, CAMK4, NGFR, PLCG2",0.581698708680255,0.204815410317576,FALSE
+"HCC827","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.32533,-0.981,0.443,8169,0.685,"NMNAT3, QPRT",0.35359627377693,0.164309428507574,FALSE
+"HCC827","Input","KEGG_NITROGEN_METABOLISM",-0.58679,-1.75,0.0427,7138,0.407,"CPS1, CA12, CA1, CA8, GLUD2, CA2",1.36957212497498,0.39040559077478,FALSE
+"HCC827","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.38359,-1.19,0.235,5818,0.616,"MAP3K7, RELA, BIRC2, TAB1, IKBKG, MAPK8, SUGT1, NFKBIB, CHUK, HSP90AB1, XIAP, MAPK14, MAPK3, IKBKB, TAB3, MAPK9, MAPK1, PYCARD",0.628932137728264,0.210419287835575,FALSE
+"HCC827","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.50889,-1.52,0.0782,6148,0.38,"LIG4, PRKDC, NHEJ1, XRCC6, XRCC5, FEN1",1.10679324694015,0.42021640338319,FALSE
+"HCC827","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.29756,0.854,0.606,338,0.862,"CDKN2A, EGFR, CDK4, TP53",0.217527375833714,0.0644927341752872,FALSE
+"HCC827","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.45648,1.34,0.129,1537,0.499,"DLL3, DTX3L, RBPJ, NUMB, ADAM17, MAML3, NCSTN, DTX2, NOTCH2, NOTCH3",0.889410289700751,0.30189945437661,FALSE
+"HCC827","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.29662,-0.893,0.537,5133,0.766,"PCNA, ERCC2, RAD23B, GTF2H5, RPA3, GTF2H2, CUL4B, GTF2H4, CETN2, CDK7, GTF2H1, ERCC1, ERCC6, CCNH, ERCC4, RAD23A, CUL4A, DDB2, XPC, XPA",0.270025714300444,0.115771230367396,FALSE
+"HCC827","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.24031,0.693,0.843,2078,0.99,"ST6GAL1, FUT8, DOLPP1, MAN1A2, B4GALT1, RPN2, DPM1, ALG6, STT3A, ALG13, MAN2A1",0.0741724253752577,0.00436480540245009,FALSE
+"HCC827","Input","KEGG_OLFACTORY_TRANSDUCTION",0.4055,1.15,0.265,2497,0.636,"CAMK2D, PDC, CAMK2B, PRKACA, CNGB1",0.576754126063192,0.196542884351586,FALSE
+"HCC827","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.42156,-1.27,0.184,7990,0.56,"DHFR, TYMS",0.735182176990464,0.2518119729938,FALSE
+"HCC827","Input","KEGG_OOCYTE_MEIOSIS",-0.36914,-1.11,0.304,5763,0.654,"SMC3, CDC26, SKP1, SMC1A, MAD2L1, ANAPC4, PRKACB, CCNB2, YWHAZ, PLK1, CAMK2G, PPP2R5C, PPP2R1B, ANAPC1, MAP2K1, PPP2R5A, SMC1B, CDC27, CDK1, ADCY5, PPP2CB, RPS6KA1, PPP2R5D, ADCY6, ITPR2, ANAPC7, PKMYT1, CUL1, MAPK3, CDC23, CDC16, ANAPC5, MAPK1, STAG3, ITPR1, CDK2, MAD2L2",0.517126416391246,0.184422251675733,FALSE
+"HCC827","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.60295,1.7,0.0541,1907,0.37,"FUCA1, AGA, FUCA2, MAN2B2, HEXB, HEXA, MANBA, GBA",1.26680273489343,0.431798275933005,FALSE
+"HCC827","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22541,0.628,0.918,2323,0.964,"COX6A1, PPA2, COX7A2, COX11, COX17, TCIRG1, COX7C, ATP5PF, COX5B, COX5A, UQCRH, COX6B1, NDUFB1, COX6C, LHPP, COX7A2L, ATP5MC2, COX4I1, NDUFB10, SDHC, UQCRFS1, COX7B, UQCRB, SDHA, SDHB, ATP6V1C1, ATP6AP1, UQCRC2, UQCRC1",0.0371573187987575,0.0159229660971692,FALSE
+"HCC827","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.62067,1.78,0.0267,1051,1,"GALNT4, GALNT8, GALNT13, GALNT7, GALNT5, GALNT3, GALNT6, GALNT15, GALNT2, C1GALT1C1",1.57348873863542,0,FALSE
+"HCC827","Input","KEGG_P53_SIGNALING_PATHWAY",0.26742,0.775,0.733,559,0.949,"CDKN2A, CDK4, TP53, TNFRSF10B, RCHY1",0.134896025358872,0.0227337875727074,FALSE
+"HCC827","Input","KEGG_PANCREATIC_CANCER",0.37719,1.07,0.33,751,0.682,"CDKN2A, EGFR, CDK4, RAC2, TGFBR2, TP53, STAT1, TGFB2, E2F3, RALB",0.481486060122112,0.166215625343521,FALSE
+"HCC827","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.5803,-1.73,0.0461,6522,0.303,"PPCDC, COASY, ENPP1, PANK4, PANK1",1.33629907461035,0.518557371497695,FALSE
+"HCC827","Input","KEGG_PARKINSONS_DISEASE",0.175,0.484,0.995,1852,0.995,"UBE2L6, UBA7, COX6A1, COX7A2, COX7C, ATP5PF, COX5B, COX5A, UQCRH, COX6B1, NDUFB1, COX6C, HTRA2, COX7A2L, ATP5MC2, COX4I1, NDUFB10, SDHC, SLC25A5, SLC25A31, UQCRFS1",0.00217691925427455,0.00217691925427455,FALSE
+"HCC827","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.3019,-0.913,0.489,6006,0.76,"NCK2, ARPC4, YWHAZ, ROCK2, ARPC1B, EZR, NCK1, ACTB, ARPC3, ARPC2, ROCK1, ARPC5, TUBA1B, TUBB1, TUBA3C, TUBB, ACTG1, CD14, TUBB2A, TUBB6, WAS, TUBAL3, ARHGEF2, HCLS1, TUBB2B",0.31069114087638,0.119186407719209,FALSE
+"HCC827","Input","KEGG_PATHWAYS_IN_CANCER",0.33588,0.947,0.467,751,0.818,"PTGS2, CDKN2A, EGFR, PML, CDH1, CDK4, LAMB3, ITGA3, ITGA2, ETS1, LAMC2, CTNNB1, ITGB1, RAC2, TGFBR2, TP53, CTNNA1, JUN, CTNNA2, STAT1, MET, ITGAV, TGFB2, E2F3, LAMB1, RALB",0.330683119433888,0.087246696328677,FALSE
+"HCC827","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.50903,-1.54,0.0618,7333,0.392,"CRYL1, DCXR, AKR1B1",1.20901152491118,0.406713932979543,FALSE
+"HCC827","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.56712,-1.68,0.0672,6180,0.337,"ALDOA, PGM2, ALDOC, PGLS, GPI, PFKL, PRPS1, PRPS1L1, PRPS2, PFKM, PGD, PFKP, TALDO1",1.17263072694617,0.472370099128661,FALSE
+"HCC827","Input","KEGG_PEROXISOME",0.39293,1.12,0.303,1309,0.644,"SOD2, ACSL4, ACOT8, SCP2, HMGCL, DHRS4, NUDT12, EPHX2, PIPOX, PEX13, SLC27A2, ACOX3, PAOX, HACL1, PECR, ABCD3, ACAA1, PEX3, ECH1",0.518557371497695,0.191114132640188,FALSE
+"HCC827","Input","KEGG_PHENYLALANINE_METABOLISM",-0.5462,-1.61,0.0517,7974,0.374,"ALDH3A1, MAOA, MAOB",1.28650945690606,0.42712839779952,FALSE
+"HCC827","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.36504,-1.05,0.37,6827,0.63,"SYNJ1, PLCG1, INPP5A, ITPR2, PIP5K1C, DGKH, CDIPT, PLCD3, PIP5K1A, OCRL, IMPA2, ITPKB, ITPR1, DGKQ, PIK3CB, ITPK1, PLCG2, ITPKA",0.431798275933005,0.200659450546418,FALSE
+"HCC827","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.36031,1.04,0.381,1755,0.682,"CP, ALAD, HMOX2, FTH1, ALAS1, HCCS",0.419075024324381,0.166215625343521,FALSE
+"HCC827","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.33219,-0.986,0.424,7762,0.699,"ME1, FABP7, FADS2, SORBS1, GK, CPT1A, CYP27A1, EHHADH",0.372634143407267,0.155522824254319,FALSE
+"HCC827","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.60303,-1.73,0.0325,7800,0.303,"AKR1D1, CYP27A1",1.48811663902113,0.518557371497695,FALSE
+"HCC827","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.54231,-1.58,0.064,6426,0.388,"IKBKG, RFX5, JAK3, BLNK, ZAP70, CD40",1.19382002601611,0.411168274405793,FALSE
+"HCC827","Input","KEGG_PRION_DISEASES",-0.59536,-1.74,0.0467,7092,0.345,"NOTCH1, MAPK3, MAP2K2, BAX, SOD1, MAPK1, C9, NCAM1",1.33068311943389,0.462180904926726,FALSE
+"HCC827","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.35668,-1.07,0.333,6539,0.631,"ANAPC1, MAP2K1, MAPK8, AKT1, CDC27, CDK1, ADCY5, RPS6KA1, ADCY6, ANAPC7, HSP90AB1, PKMYT1, MAPK14, MAPK3, CDC23, RAF1, AKT3, MAPK9, CDC16, ANAPC5, AKT2, MAPK1, CDK2, PIK3CB, MAD2L2",0.47755576649368,0.199970640755866,FALSE
+"HCC827","Input","KEGG_PROPANOATE_METABOLISM",-0.36247,-1.09,0.318,7705,0.621,"ACAT2, ACSS2, ACSS1, ACSS3, EHHADH",0.497572880015567,0.20690839982342,FALSE
+"HCC827","Input","KEGG_PROSTATE_CANCER",-0.26497,-0.797,0.671,6273,0.817,"SOS1, CCND1, IKBKG, MAP2K1, MTOR, AKT1, CHUK, RB1, HSP90AB1, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, TCF7L1, AKT2, CASP9, MAPK1, CDK2, PIK3CB, FGFR1",0.173277479831008,0.0877779434675845,FALSE
+"HCC827","Input","KEGG_PROTEASOME",0.36334,1.04,0.382,474,0.682,"PSMB10, PSMB9, PSMB8",0.417936637088291,0.166215625343521,FALSE
+"HCC827","Input","KEGG_PROTEIN_EXPORT",0.19957,0.553,0.972,1782,0.991,"OXA1L, SRPRA, HSPA5, SRPRB",0.0123337350737254,0.00392634551472468,FALSE
+"HCC827","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.59592,-1.78,0.0529,7909,0.409,"ATP1B3, GLUD2, CA2",1.27654432796481,0.388276691992658,FALSE
+"HCC827","Input","KEGG_PURINE_METABOLISM",-0.35688,-1.09,0.297,6266,0.621,"PRIM1, NT5C2, POLR3D, ADSL, PAPSS1, NT5C, AMPD3, PRIM2, PRPS1, PRPS1L1, ADCY5, PKLR, AMPD2, POLR3C, PRPS2, ADCY6, PAICS, NME7, GMPS, PPAT, ENPP1, DCK, AK5, IMPDH1, ENTPD4, NT5C3A, PKM, ENTPD8, GMPR, NUDT2, PDE4D, PDE8A, NME4, RRM2B, RRM2, NUDT5, RRM1, POLR2F",0.527243550682788,0.20690839982342,FALSE
+"HCC827","Input","KEGG_PYRIMIDINE_METABOLISM",-0.23456,-0.675,0.858,6831,0.93,"UMPS, POLR3C, NME7, DCK, CTPS2, ENTPD4, NT5C3A, ENTPD8, NUDT2, DUT, NME4, RRM2B, RRM2, UCK2, RRM1, TYMS, POLR2F",0.0665127121512946,0.0315170514460649,FALSE
+"HCC827","Input","KEGG_PYRUVATE_METABOLISM",-0.36411,-1.09,0.309,6232,0.621,"ACACA, MDH1, GRHPR, PC, ALDH7A1, ALDH2, PKLR, GLO1, PKM, ACYP2, HAGH, ACAT2, ACSS2, ME1, AKR1B1, ACSS1",0.510041520575165,0.20690839982342,FALSE
+"HCC827","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.32198,0.928,0.498,552,0.781,"ITGB6, PIP4K2C, ITGB2, EGFR, ITGA1, ITGA3, ITGA2, ITGA5, ITGB1, RAC2, GNG12, ITGAV, CFL2",0.302770657240282,0.1073489661227,FALSE
+"HCC827","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.24024,-0.732,0.802,5510,0.863,"PRKAA1, ATG3, ATG7, ATG4B",0.0958256317158365,0.0639892042847904,FALSE
+"HCC827","Input","KEGG_RENAL_CELL_CARCINOMA",-0.21373,-0.635,0.9,7197,0.96,"EGLN1, MAPK3, RAF1, MAP2K2, AKT3, AKT2, MAPK1, CRKL, PIK3CB",0.0457574905606751,0.0177287669604316,FALSE
+"HCC827","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.40697,-1.17,0.272,7860,0.602,"ANPEP, MME",0.565431095965801,0.220403508742175,FALSE
+"HCC827","Input","KEGG_RETINOL_METABOLISM",0.54332,1.56,0.0595,1049,0.43,"RDH10, DHRS3, DHRS4, PNPLA4, RDH11",1.22548303427145,0.366531544420413,FALSE
+"HCC827","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.43527,-1.28,0.172,6704,0.561,"ACP2, ENPP1, MTMR6, TYR, MTMR2",0.764471553092451,0.251037138743839,FALSE
+"HCC827","Input","KEGG_RIBOSOME",-0.5251,-1.57,0.0573,5682,0.377,"RPS25, RPL21, RPL34, RPL32, RPS28, RPL5, RPL36, RPS2, RPL28, RPS7, RPS8, RPS6, RPL17, RPL7, RPL10, RPL15, RPL6, RPL26, RPL35A, RPL3, RPL23A, RPL10A, RPL12, RPL19, RPLP0, RPL13A, RPS10, UBA52, RPL4, RPS26, RPS17, RPL30, RPS15, RPL7A, RPS11, RPS3A, RPL31, RPS24, RPL18A, RPS19, RPL9, RPS15A, RPS13, RPS9, RPS5, RPS16, RPS3, RPL14, RPS4X, RPS27L, RPL22, RPL8, RPL27A, RPS20, RPL35, RPS18, RPL26L1",1.24184537803261,0.423658649794207,FALSE
+"HCC827","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.39221,-1.17,0.243,8272,0.602,"DDX3Y",0.614393726401688,0.220403508742175,FALSE
+"HCC827","Input","KEGG_RNA_DEGRADATION",-0.14669,-0.447,0.997,1866,0.998,"HSPD1, LSM6, LSM2, LSM3, LSM8, HSPA9, XRN2, CNOT2, LSM7, PATL1, EXOSC5, DCP1B, ENO1, DCP1A, EXOSC1, DCP2, EDC3, LSM4, EXOSC2, TTC37, MTREX, SKIV2L, WDR61, EXOSC4, CNOT3, EXOSC3, EDC4, EXOSC7, ENO3, EXOSC8, CNOT7, DIS3, PAPOLG, CNOT10, ENO2, MPHOSPH6, EXOSC9, C1D, PAPOLA, EXOSC6, ZCCHC7, EXOSC10, CNOT4, CNOT1, PARN, XRN1, DCPS, CNOT9, DDX6, LSM1",0.00130484168834428,0.000869458712628891,FALSE
+"HCC827","Input","KEGG_RNA_POLYMERASE",-0.30648,-0.892,0.541,8204,0.757,"POLR2F",0.266802734893431,0.120904120499927,FALSE
+"HCC827","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.33493,-1.02,0.35,7042,0.66,"SEPHS2, MAT1A, AHCY, SEPHS1, METTL2B, BUD23, LCMT1",0.455931955649724,0.180456064458131,FALSE
+"HCC827","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.43864,1.25,0.192,1123,0.599,"PTGS2, CDK4, LAMB3, ITGA3, ITGA2, LAMC2, ITGB1, TP53, ITGAV, E2F3, LAMB1, ITGA6, MAX, LAMA5, PIK3R3",0.71669877129645,0.222573177610689,FALSE
+"HCC827","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.41152,1.16,0.255,2182,0.674,"STX17, VAMP8, STX18, STX3, STX6, BNIP1, STX8, STX12, GOSR1, VTI1B, SEC22B, SNAP47, STX7",0.593459819566045,0.17134010346468,FALSE
+"HCC827","Input","KEGG_SPHINGOLIPID_METABOLISM",0.49217,1.41,0.11,2056,0.474,"PLPP2, PLPP1, UGT8, GLA, GALC, ASAH1, PLPP3, SPHK2, GBA, SMPD1, SPTLC1",0.958607314841775,0.324221658325915,FALSE
+"HCC827","Input","KEGG_SPLICEOSOME",0.27832,0.778,0.706,3534,0.958,"HNRNPA1, SRSF7, SNRNP27, ACIN1, HNRNPM, SF3B5, PRPF40A, NCBP2, ZMAT2, HNRNPU, SART1, PRPF19, PRPF4, WBP11, SRSF5, TRA2A, SNRNP40, DHX38, CWC15, LSM6, SRSF6, LSM2, LSM3, U2AF2, CDC5L, U2AF1, SNRPF, SNRPG, SNRNP70, HNRNPA3, SRSF10, LSM8, BCAS2, SNRPB, RBM25, PRPF31, PRPF38B, SF3B6, SF3A1, PRPF38A, HSPA6, SRSF9, HNRNPC, SNRPC, TRA2B, SF3B2, SF3B3, HNRNPK, LSM7, PQBP1, DDX5, SNW1, SNRPA, TCERG1, DDX23, PUF60, SLU7, XAB2, PLRG1, EFTUD2, SRSF3, SF3A2, DDX39B, SNU13, SRSF1, SNRPD3, TXNL4A, RBM8A, PPIL1, PPIH, PHF5A, SF3A3",0.151195298948196,0.0186344909214556,FALSE
+"HCC827","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.33452,0.949,0.481,846,0.83,"PGM2L1, GAA, UGDH, UXS1, PYGL",0.317854923626168,0.0809219076239261,FALSE
+"HCC827","Input","KEGG_STEROID_BIOSYNTHESIS",-0.36869,-1.06,0.337,6533,0.637,"CYP51A1, LSS, CEL, LIPA, MSMO1, SOAT2, SQLE",0.472370099128661,0.19586056766465,FALSE
+"HCC827","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.46991,-1.41,0.111,6750,0.416,"SRD5A1, CYP21A2, COMT, HSD17B2, SULT2B1, AKR1C3, AKR1D1, AKR1C1",0.954677021213343,0.380906669373257,FALSE
+"HCC827","Input","KEGG_SULFUR_METABOLISM",-0.55821,-1.66,0.0366,7685,0.337,"SULT2B1, SULT1A1, CHST12",1.43651891460559,0.472370099128661,FALSE
+"HCC827","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.51444,-1.5,0.0823,6007,0.386,"ACTN4, ACTN1, ACTN2, C4A, C9, CD40",1.08460016478773,0.413412695328245,FALSE
+"HCC827","Input","KEGG_TASTE_TRANSDUCTION",0.48765,1.4,0.115,2777,0.468,"SCNN1A, GNB3, ITPR3, GNB1, PRKACA, KCNB1, CACNA1A",0.939302159646388,0.329754146925876,FALSE
+"HCC827","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.64977,-1.92,0.0216,6772,0.617,"GGPS1, MVK, ACAT2, PMVK, HMGCS1, FDPS, IDI1",1.66554624884907,0.209714835966758,FALSE
+"HCC827","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.31245,-0.93,0.486,6369,0.748,"PPP2R1B, RPS6KB2, SMAD1, SMAD4, ROCK1, SMAD5, PPP2CB, SMAD2, SMAD9, CUL1, MAPK3, INHBE, RPS6KB1, THBS2, MAPK1, ID1",0.313363730737707,0.126098402135539,FALSE
+"HCC827","Input","KEGG_THYROID_CANCER",0.40571,1.15,0.262,338,0.636,"CDH1, CTNNB1, TP53",0.581698708680255,0.196542884351586,FALSE
+"HCC827","Input","KEGG_TIGHT_JUNCTION",0.45473,1.31,0.153,1351,0.53,"CDK4, OCLN, EPB41L1, CLDN6, RAB3B, CLDN3, CLDN4, CTNNB1, CGN, F11R, TJP2, CTNNA1, CTNNA2, TJP3, TJP1, MPDZ, AFDN, PATJ, LLGL1, GNAI1, GNAI3, CASK, EXOC4, CLDN1, PARD3, PRKCB, SRC",0.815308569182401,0.275724130399211,FALSE
+"HCC827","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.32552,-0.981,0.43,6198,0.685,"TAB1, IRF3, RIPK1, IKBKG, IRAK4, TRAF3, MAP2K1, MAPK8, AKT1, CHUK, MAPK14, MAPK3, IFNAR1, CD14, MAP2K2, AKT3, IKBKB, MAPK9, AKT2, MAPK1, PIK3CB, LBP, CD40",0.366531544420413,0.164309428507574,FALSE
+"HCC827","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.47167,-1.44,0.116,7705,0.411,"ACAT2, AADAT, MAOA, MAOB, EHHADH",0.935542010773082,0.386158178123931,FALSE
+"HCC827","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.63282,-1.87,0.0323,6598,0.464,"MTOR, MAPK8, PKLR, PRKCD, MAPK3, PKM, IKBKB, MAPK9, IRS2, MAPK1, PIK3CB, HK3, GCK",1.4907974776689,0.333482019445119,FALSE
+"HCC827","Input","KEGG_TYROSINE_METABOLISM",-0.59036,-1.74,0.035,7770,0.345,"TYR, METTL2B, DCT, ALDH3A1, BUD23, LCMT1, MAOA, MAOB",1.45593195564972,0.462180904926726,FALSE
+"HCC827","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.29288,-0.846,0.578,6273,0.773,"SOS1, NCK1, PRKCQ, IKBKG, MAP2K1, NFAT5, CBL, AKT1, PLCG1, NFKBIB, CHUK, MAPK14, MAPK3, RAF1, MAP2K2, AKT3, IKBKB, GSK3B, MAPK9, AKT2, MAPK1, PIK3CB, ZAP70",0.238072161579471,0.111820506081675,FALSE
+"HCC827","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.30347,-0.875,0.565,6766,0.768,"CDC27, FANCL, CUL7, HUWE1, UBE2F, UBE2E1, CDC34, CUL4A, ANAPC7, SAE1, MID1, DDB2, CUL1, UBE2Q1, PIAS1, PPIL2, XIAP, UBA1, UBE2E3, UBE2G2, CDC23, PIAS4, UBE2S, UBE2B, FBXW7, UBE3A, HERC1, PIAS2, RNF7, CDC16, UBE2L3, ANAPC5, UBA2, UBE2M, HERC4, FBXO2",0.247951552180562,0.114638779968488,FALSE
+"HCC827","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.29309,0.849,0.638,2807,0.858,"PDHB, PDHA1, IARS2",0.195179321278838,0.0665127121512946,FALSE
+"HCC827","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37663,1.1,0.321,1450,0.652,"ACADS, IVD, HMGCL, ACAD8, DBT, ALDH1B1, MCCC1, AUH, ACAA1, HIBCH, HIBADH, MCCC2, ACADM, ALDH6A1",0.493494967595128,0.18575240426808,FALSE
+"HCC827","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.29063,-0.86,0.595,6004,0.766,"ACTA2, PRKACB, PLCB1, ROCK2, MYH11, PRKCQ, MAP2K1, ROCK1, ADCY5, ADCY6, ITPR2, PRKCD, MAPK3, RAF1, MAP2K2, MAPK1, ITPR1, ARHGEF1, ARHGEF11, KCNMA1",0.22548303427145,0.115771230367396,FALSE
+"HCC827","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33272,0.934,0.499,2090,0.798,"ARHGDIB, RAB11A, CREB1, RAB11B, DYNC1LI2, RAB5B, DYNLL2, ADCY9, RAB5A, CREB5, RAB5C",0.30189945437661,0.0979971086492706,FALSE
+"HCC827","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.28054,-0.844,0.64,7259,0.767,"MAPK14, MAPKAPK2, MAPK3, RAF1, MAP2K2, AKT3, AKT2, CASP9, MAPK1, PIK3CB, PLCG2",0.193820026016113,0.115204636051019,FALSE
+"HCC827","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.20452,0.581,0.965,1059,0.989,"ERO1A, TJP2, TCIRG1, TJP1, SLC12A2, PDIA4",0.0154726866562074,0.0048037084028206,FALSE
+"HCC827","Input","KEGG_VIRAL_MYOCARDITIS",0.32775,0.932,0.525,255,0.787,"ITGB2, CXADR, ICAM1, RAC2",0.279840696594043,0.104025267640935,FALSE
+"HCC827","Input","KEGG_WNT_SIGNALING_PATHWAY",0.31177,0.892,0.579,678,0.799,"CTNNB1, LRP5, PLCB4, RAC2, TP53, JUN, CAMK2D, DAAM1, DAAM2, CHD8",0.237321436272564,0.0974532206860086,FALSE
+"HCC95","Input","KEGG_ABC_TRANSPORTERS",0.39284,1.15,0.261,1732,0.639,"ABCC5, ABCC8, ABCC3, ABCC1, ABCC4, TAP1, ABCB10, TAP2, ABCB6, ABCC2",0.583359492661719,0.1944991418416,FALSE
+"HCC95","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.28754,0.816,0.635,1460,0.809,"PML, IKBKB, KRAS, NRAS, RARA, HRAS, BAD, MYC, EIF4EBP1, STAT3",0.197226274708024,0.0920514783877277,FALSE
+"HCC95","Input","KEGG_ADHERENS_JUNCTION",0.34188,0.996,0.424,1106,0.734,"NECTIN1, EGFR, YES1, IGF1R, PTPN6, RAC2, SMAD3, RAC3, SRC, CTNND1, ACTN4, MET",0.372634143407267,0.134303940083929,FALSE
+"HCC95","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.29338,0.861,0.594,822,0.806,"SLC2A1, RXRA, IKBKB, IRS1, PCK2",0.226213555018806,0.0936649581949093,FALSE
+"HCC95","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32401,-0.965,0.446,7877,0.831,"CPS1, GPT, GLS, GLS2, GLUD2",0.350665141287858,0.080398976215889,FALSE
+"HCC95","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.28782,0.844,0.607,1227,0.815,"ATP1B3, IRS1, KRAS, ATP1A3, ATP1B1, ATP1A1, ATP1A4, SFN",0.216811308924742,0.0888423912600234,FALSE
+"HCC95","Input","KEGG_ALZHEIMERS_DISEASE",-0.32101,-0.935,0.493,6408,0.823,"FADD, COX7A2, COX4I1, NDUFS2, UQCRQ, NDUFA3, LPL, GSK3B, NDUFAB1, APH1A, NCSTN, CASP3, COX5A, NDUFB4, PPP3CC, MME, MAPK1, NDUFB7, COX6C, NDUFA2, EIF2AK3, MAPK3, COX7C, CAPN2, HSD17B10, CYCS, CALM2, PPP3R1, PPP3R2, PSEN2, COX7B, APOE, PSEN1, BACE2, ATP5MC2",0.30715308072277,0.0846001647877302,FALSE
+"HCC95","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.34247,-1.02,0.39,5695,0.786,"PARS2, FARSB, TARS2, AARS2, LARS2, FARS2, YARS2, FARSA, EARS2, MARS2, CARS2",0.408935392973501,0.104577453960592,FALSE
+"HCC95","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.40248,-1.19,0.234,6876,0.656,"UGP2, GMPPB, GALK1, CYB5R3, GALK2, GNPNAT1, PMM2, GMDS, AMDHD2, RENBP, NAGK, GALT, GNE, GCK, PGM1, UAP1",0.630784142589857,0.18309616062434,FALSE
+"HCC95","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.32409,-0.967,0.462,7912,0.843,"NEFL, RAB5A, TOMM40L, MAP3K5, CYCS, PPP3R1, PPP3R2, NEFH, PRPH, PRPH2",0.335358024443874,0.0741724253752577,FALSE
+"HCC95","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.38863,1.15,0.262,2128,0.639,"CTSB, TAPBP, B2M, NFYB, HSPA5, NFYA, TAP1, PSME1, TAP2, PSME2, HSPA1A, CANX, CTSL, NFYC, HSPA6, PSME3",0.581698708680255,0.1944991418416,FALSE
+"HCC95","Input","KEGG_APOPTOSIS",-0.30823,-0.907,0.547,7082,0.827,"CASP3, AKT3, PPP3CC, IRAK4, CASP6, PRKACA, PRKAR2B, AIFM1, AKT1, EXOG, MYD88, CAPN2, PIK3CB, CYCS, PPP3R1, PPP3R2, PRKACB, RIPK1",0.262012673666569,0.0824944904474534,FALSE
+"HCC95","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.43307,1.28,0.163,1264,0.621,"AKR1C3, CYP4F3, CBR1, EPHX2, GPX2, PTGS2, ALOX5, CBR3, PTGES2",0.787812395596042,0.20690839982342,FALSE
+"HCC95","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34959,1.02,0.39,1592,0.732,"CKMT1A, CKMT2, ODC1, ASS1, PYCR2, SAT2, GATM, PYCR1, ARG1, P4HA2, OTC, ALDH4A1, GOT2, ALDH2, MAOA, GLUL, SAT1, PRODH, PRODH2, ALDH3A2",0.408935392973501,0.135488918941608,FALSE
+"HCC95","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.31875,0.941,0.462,622,0.777,"ITGB4, GJA1, ITGA2, ITGA6, ITGA5, ITGA3, CDH2, ITGB8",0.335358024443874,0.109578981199086,FALSE
+"HCC95","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.69405,-2.08,0.00741,8524,0.203,"ALDH9A1, ALDH7A1",2.13018179202067,0.692503962086787,TRUE
+"HCC95","Input","KEGG_AXON_GUIDANCE",0.36922,1.08,0.349,1256,0.69,"EFNA5, EFNB1, UNC5B, SEMA4D, SEMA4B, SEMA5B, PLXNB2, EFNB2, EPHA2, ROBO2, RAC2, NTN4, EFNB3, PLXNA2, EPHB3, KRAS, NRAS, RAC3, SEMA3C, NCK1, HRAS, MET, EPHA6, SLIT1, SLIT3, NTN1",0.45717457304082,0.161150909262745,FALSE
+"HCC95","Input","KEGG_BASAL_CELL_CARCINOMA",0.50903,1.5,0.0707,1596,0.339,"FZD1, WNT5A, FZD6, FZD2, DVL3, TP53",1.1505805862031,0.469800301796918,FALSE
+"HCC95","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.50586,1.5,0.0938,2318,0.339,"TAF7, TAF1, GTF2A2, TAF2, GTF2F2, GTF2B, GTF2H1, GTF2H4, GTF2H3, TAF9, TAF6, TBPL1",1.02779716162094,0.469800301796918,FALSE
+"HCC95","Input","KEGG_BASE_EXCISION_REPAIR",0.51717,1.54,0.0795,3256,0.369,"POLB, PARP2, POLD3, APEX1, POLD4, POLE, POLD1, LIG3, TDG, POLE4, POLD2, HMGB1, PARP1, XRCC1, POLE3, FEN1, MPG, MBD4, PCNA",1.09963287134353,0.43297363384094,FALSE
+"HCC95","Input","KEGG_BETA_ALANINE_METABOLISM",-0.6157,-1.84,0.019,8121,0.225,"SRM, SMS, ALDH9A1, ALDH7A1",1.72124639904717,0.647817481888638,TRUE
+"HCC95","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.54086,-1.61,0.0384,7833,0.27,"ACOT7, ACOT2, PECR, ACOX3, YOD1, ACAA1, ACOT1, ACOT4",1.41566877563247,0.568636235841013,FALSE
+"HCC95","Input","KEGG_BLADDER_CANCER",0.43275,1.27,0.197,1129,0.591,"EGFR, KRAS, NRAS, THBS1, RPS6KA5, RB1, HRAS, MYC",0.705533773838407,0.228412519118745,FALSE
+"HCC95","Input","KEGG_BUTANOATE_METABOLISM",-0.33985,-0.993,0.429,7232,0.798,"AACS, PDHA1, PDHB, BDH2, ACAT1, ALDH9A1, ALDH7A1",0.367542707815276,0.0979971086492706,FALSE
+"HCC95","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.25152,-0.729,0.832,6772,0.926,"NFKBIB, GSK3B, AKT2, NFAT5, AKT3, CD81, PPP3CC, MAPK1, PIK3AP1, MAPK3, SOS1, AKT1, INPP5D, PIK3CB, PPP3R1, PPP3R2, PRKCB, NFATC2",0.0798766737092761,0.0333890133180656,FALSE
+"HCC95","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.29773,-0.875,0.606,8274,0.856,"MYLK, CALM2, PPP3R1, ERBB3, PPP3R2, PRKACB, PRKCB, SPHK2, CACNA1A, BST1, PDE1C",0.217527375833714,0.0675262353228468,FALSE
+"HCC95","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.27473,-0.808,0.693,6417,0.883,"COX7A2, COX4I1, CACNB2, UQCRQ, TPM4, TPM1, SLC8A1, COX5A, COX6C, MYL3, SLC9A6, CACNA2D1, COX7C, TPM3, TPM2, COX7B",0.159266765388193,0.0540392964224314,FALSE
+"HCC95","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.50287,1.48,0.0884,444,0.347,"NECTIN1, CLDN11, SDC1, JAM3, CDH4, CNTN1, CLDN6, CD40, ITGA6, CD274, CLDN1, CNTNAP1, CDH2, ALCAM, CDH15, CDH3",1.05354773498693,0.459670525209126,FALSE
+"HCC95","Input","KEGG_CELL_CYCLE",0.2799,0.839,0.648,2343,0.8,"TGFB2, CDC23, SMAD3, ANAPC4, CDC16, ANAPC7, ANAPC5, RBL1, CDC26, RB1, ORC3, CDC27, MYC, SFN, TFDP2, CDKN1B, CDK7, ANAPC1, ATM, SMC1B, TP53, BUB3, CCNB1, BUB1B, ORC4, MAD1L1, YWHAG, MCM5, MCM4, MCM3, RAD21, RBX1, CUL1, PRKDC, FZR1, SMC3, MCM6",0.188424994129407,0.0969100130080564,FALSE
+"HCC95","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.22284,-0.659,0.913,6849,0.995,"GSK3B, AKT2, GNB1, GSK3A, CXCL14, AKT3, ROCK1, ROCK2, RAP1A, MAPK1, PRKACA, GRK2, CCL13, GNG7, RAP1B, MAPK3, ARRB2, ADCY5, SOS1, AKT1, STAT2, CCL15, TIAM1, CSK, PIK3CB, PRKACB, ARRB1, ADCY6, PRKCB",0.039529222465701,0.00217691925427455,FALSE
+"HCC95","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.19649,0.585,0.968,1405,0.976,"IKBKB, TGFB2, SMAD3, KRAS, NRAS, RB1, HRAS, BAD, GAB2, MYC, BCL2L1, CDKN1B",0.0141246426916063,0.0105501823333082,FALSE
+"HCC95","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.20983,-0.614,0.95,5925,1,"ACO1, DLD, IDH1, IDH3G, MDH1, CS, SUCLG1, PDHA1, PDHB, SUCLG2, IDH2",0.0222763947111523,0,FALSE
+"HCC95","Input","KEGG_COLORECTAL_CANCER",-0.20102,-0.581,0.965,6480,0.987,"CCND1, PIK3R1, BAX, CTNNB1, GSK3B, AKT2, CASP3, APPL1, AKT3, MAPK1, MAPK3, AKT1, TGFB3, PIK3CB, CYCS, SMAD2",0.0154726866562074,0.00568284733036327,FALSE
+"HCC95","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.56546,1.68,0.0307,795,0.295,"C9, PLAU, PLAT, F3, C3, VWF, CFH, MBL2",1.51286162452281,0.530177984021837,FALSE
+"HCC95","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.29591,-0.893,0.564,7600,0.83,"DNMT1, MTR, LDHA, SRM, SMS, ADI1, AMD1",0.248720896016658,0.0809219076239261,FALSE
+"HCC95","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.55509,1.66,0.0421,611,0.292,"EGFR, NGFR, IFNGR1, IL1RAP, CD40, IL1R2, LTBR, ACVR1, TGFB2, IL18, PLEKHO2, CXCL6",1.37571790416433,0.534617148551582,FALSE
+"HCC95","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.35365,1.03,0.402,905,0.762,"ZBP1, CASP1, IKBKB, IL18, MAVS",0.39577394691553,0.1180450286604,FALSE
+"HCC95","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.3576,-1.04,0.362,7283,0.811,"SGCD, DMD, PRKACA, MYL3, ITGB1, ACTG1, ADCY5, CACNA2D1, TPM3, TGFB3, TPM2, ITGA1, ITGA7, PRKACB, ADCY6, ITGA4, ITGB5, DES, ITGB3",0.441291429466834,0.090979145788844,FALSE
+"HCC95","Input","KEGG_DNA_REPLICATION",0.42673,1.22,0.215,2505,0.622,"RFC2, SSBP1, POLD3, RFC4, RFC5, POLD4, RNASEH2A, POLE, POLD1, RPA3, MCM5, RPA2, MCM4, MCM3, POLE4, POLD2, MCM6, RPA1",0.667561540084395,0.206209615309181,FALSE
+"HCC95","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.38939,1.16,0.231,1183,0.658,"EGFR, KRAS, ETV6",0.636388020107856,0.181774106386044,FALSE
+"HCC95","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.59062,1.72,0.0324,162,0.302,"ADH4, ADH7, ALDH3A1, GSTM3",1.48945498979339,0.519993057042849,FALSE
+"HCC95","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.34528,1.01,0.388,2331,0.721,"CES1, CES2, GMPS, TPMT, IMPDH1, NAT2, NAT1, XDH, IMPDH2, HPRT1, UCKL1, GUSB",0.411168274405793,0.142064735280571,FALSE
+"HCC95","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.40015,1.18,0.228,741,0.658,"CD44, SDC1, ITGB4, LAMA1, ITGA2, ITGA6, LAMB3, TNC, ITGA5, ITGA3, LAMC2, VWF, ITGB8, LAMA5, THBS1",0.642065152999546,0.181774106386044,FALSE
+"HCC95","Input","KEGG_ENDOCYTOSIS",-0.2701,-0.786,0.724,7143,0.891,"RABEP1, SH3GLB1, DNM1L, ASAP1, CBLB, VPS4A, EHD1, NEDD4L, CHMP2B, GRK2, PLD1, STAM, VPS37A, DNM2, MVB12B, PIP4K2B, RAB5B, SMAP2, ARRB2, SH3GL1, RAB5A, HSPA1L, RAB11B, ASAP2, RAB11FIP5, HSPA2, IQSEC1, PARD6B, ACAP1, DAB2, ERBB3, WWP1, PARD6G, ITCH, ARRB1, DNAJC6, SH3KBP1",0.140261433802853,0.0501222959631252,FALSE
+"HCC95","Input","KEGG_ENDOMETRIAL_CANCER",0.27796,0.814,0.666,1596,0.801,"EGFR, KRAS, NRAS, HRAS, BAD, MYC, MLH1, FOXO3, TP53",0.176525770829699,0.0963674839157623,FALSE
+"HCC95","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.39358,1.14,0.262,1106,0.623,"EGFR, PTPRZ1, JAM3, IKBKB, LYN, ADAM17, JUN, MAPK12, SRC, F11R, MET",0.581698708680255,0.20551195334083,FALSE
+"HCC95","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.2687,0.809,0.693,1129,0.799,"NRG1, EGFR, JUN, KRAS, NRAS, NCK1, SRC, HRAS, BAD, MYC",0.159266765388193,0.0974532206860086,FALSE
+"HCC95","Input","KEGG_ETHER_LIPID_METABOLISM",-0.4131,-1.21,0.215,7460,0.703,"PLD1, AGPS, PAFAH1B3, PAFAH2, PLA2G12A",0.667561540084395,0.153044674980176,FALSE
+"HCC95","Input","KEGG_FATTY_ACID_METABOLISM",0.32621,0.954,0.477,4,0.763,"ADH4, ADH7",0.321481620959886,0.11747546204512,FALSE
+"HCC95","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.22993,-0.672,0.887,6376,0.99,"VAV2, MAP2K2, PIK3R1, MAP2K3, MAP2K4, AKT2, AKT3, PRKCE, MAPK14, MAPK1, PRKCA, PLCG1, MAPK3, SOS1, MAP2K7, AKT1, INPP5D, PIK3CB, PLA2G12A, PRKCB",0.0520763801682736,0.00436480540245009,FALSE
+"HCC95","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.45128,-1.33,0.142,7113,0.568,"ARPC3, AKT3, DNM1L, PRKCE, ASAP1, MAPK1, PRKCA, PLD1, WASF2, DNM2, PIP4K2B, PLCG1, MAPK3, GSN, AKT1, MARCKS, PRKCG, VASP, INPP5D, ASAP2, PIK3CB, SCIN, PRKCB, SPHK2, CFL2, PTPRC, AMPH, MARCKSL1",0.847711655616944,0.245651664288981,FALSE
+"HCC95","Input","KEGG_FOCAL_ADHESION",0.30851,0.904,0.532,823,0.798,"EGFR, CAV1, CAV2, ITGB4, LAMA1, ITGA2, ITGA6, LAMB3, VAV1, TNC, ITGA5, ITGA3, IGF1R, LAMC2, RAC2, VWF, JUN, ITGB8, LAMA5, RAC3, THBS1, SRC",0.274088367704952,0.0979971086492706,FALSE
+"HCC95","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.6915,-2.04,0.00938,6964,0.189,"GGH, PTS, ALPI, ALPP, ALPL",2.02779716162094,0.723538195826756,TRUE
+"HCC95","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.31105,0.916,0.534,267,0.802,"AKR1B10, ALDOC, AKR1B1",0.272458742971444,0.0958256317158365,FALSE
+"HCC95","Input","KEGG_GALACTOSE_METABOLISM",-0.3265,-0.956,0.472,6547,0.821,"HK2, GALE, GLB1, UGP2, GALK1, PFKL, GALK2, PFKP, GALT, GCK, PGM1",0.326058001365912,0.0856568428805592,FALSE
+"HCC95","Input","KEGG_GAP_JUNCTION",0.24179,0.72,0.813,1246,0.885,"EGFR, GJA1, KRAS, NRAS, SRC, PLCB4, ADCY3, ADCY8, HRAS, MAP3K2, TUBA4A",0.0899094544059319,0.0530567293021746,FALSE
+"HCC95","Input","KEGG_GLIOMA",-0.26594,-0.78,0.718,7341,0.879,"MAPK1, PRKCA, PLCG1, MAPK3, SOS1, AKT1, PRKCG, CDK6, PIK3CB, CALM2, PRKCB, CDKN2A",0.1438755557577,0.0560111249262281,FALSE
+"HCC95","Input","KEGG_GLUTATHIONE_METABOLISM",0.34949,1.02,0.374,897,0.732,"GCLC, GCLM, GSTM3, ODC1, PGD, GPX2, GSS, GSTP1, GSR, G6PD",0.42712839779952,0.135488918941608,FALSE
+"HCC95","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.54756,-1.61,0.0575,8387,0.27,"CEL, GK, ALDH9A1, ALDH7A1, MGLL",1.24033215531037,0.568636235841013,FALSE
+"HCC95","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33046,0.974,0.439,1358,0.751,"LPCAT3, PCYT1B, PCYT1A, PLPP1, DGKA, LCLAT1, DGKZ, LPCAT2, CDIPT, PISD",0.357535479757879,0.124360062995832,FALSE
+"HCC95","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.40043,1.16,0.272,1202,0.658,"PIPOX, GATM, PHGDH, PSAT1, MAOA, PSPH",0.565431095965801,0.181774106386044,FALSE
+"HCC95","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.36729,1.09,0.326,175,0.706,"ADH4, ADH7, ALDH3A1, ALDOC",0.486782399932061,0.151195298948196,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.41301,1.19,0.24,1065,0.66,"XYLT2, CHST14, B4GALT7",0.619788758288394,0.180456064458131,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.57653,1.72,0.0309,1478,0.302,"HS6ST2, XYLT2, B4GALT7, EXTL2",1.51004152057517,0.519993057042849,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.55906,-1.64,0.0441,6606,0.288,"FUT8, B4GALT3, B4GAT1, B4GALT4, ST3GAL2",1.35556141053216,0.540607512240769,FALSE
+"HCC95","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.27533,0.821,0.653,3109,0.811,"IDS, HPSE, HEXB, ARSB, GUSB, SGSH, HEXA",0.185086818724926,0.090979145788844,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.26283,-0.769,0.746,8275,0.878,"ST3GAL2",0.127261172527331,0.0565054840938974,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.41618,1.27,0.172,1786,0.591,"GLA, FUT1, HEXB",0.764471553092451,0.228412519118745,FALSE
+"HCC95","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.59234,-1.74,0.0364,8249,0.259,"B4GALT4, GCNT2, ST3GAL6, ST3GAL4, B3GNT3",1.43889861635094,0.586700235918748,FALSE
+"HCC95","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.29889,0.877,0.586,6214,0.842,"PIGB, PIGS, PIGX, PGAP1, PIGU, PIGT, PIGO, PIGG, GPAA1, PIGK, PIGW, PIGA",0.232102383981909,0.0746879085003505,FALSE
+"HCC95","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.55036,-1.62,0.0549,6527,0.292,"MDH1, CS, PGP, HYI",1.26042765554991,0.534617148551582,FALSE
+"HCC95","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.27382,0.802,0.674,1177,0.79,"EGFR, MMP14, JUN, MAPK12, KRAS, NRAS, SRC, PLCB4, ADCY3, ADCY8, ATF4, HRAS, MAP3K2, CALML3",0.17134010346468,0.102372908709559,FALSE
+"HCC95","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.29688,-0.867,0.569,6745,0.861,"WNT11, GSK3B, PRKACA, CSNK1G2, SHH, CSNK1D, PRKACB",0.244887733604929,0.0649968485463452,FALSE
+"HCC95","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.52269,1.55,0.0887,442,0.379,"CD44, ITGA2, ITGA6, IL1R2, ITGA5, ITGA3, CD9",1.05207638016827,0.421360790031928,FALSE
+"HCC95","Input","KEGG_HISTIDINE_METABOLISM",-0.34838,-1.02,0.39,8524,0.786,"ALDH9A1, ALDH7A1",0.408935392973501,0.104577453960592,FALSE
+"HCC95","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.62976,1.83,0.0197,2505,0.239,"TOP3B, RAD54L, SSBP1, POLD3, BLM, POLD4, POLD1, RPA3, RPA2, MUS81, RAD51, POLD2, RPA1",1.70553377383841,0.621602099051862,TRUE
+"HCC95","Input","KEGG_HUNTINGTONS_DISEASE",-0.21332,-0.62,0.928,5918,1,"NDUFB1, AP2A2, SLC25A31, NDUFA8, DCTN4, NDUFB8, DCTN1, COX5B, NDUFS7, CLTB, CREB5, CLTA, COX7A2, COX4I1, NDUFS2, UQCRQ, HTT, POLR2H, DCTN2, NDUFA3, BAX, SLC25A6, NDUFAB1, CASP3, TBP, GPX1, COX5A, NDUFB4, HDAC2, NDUFB7, COX6C, NDUFA2, COX7C, SLC25A4, CYCS, COX7B, TGM2, ATP5MC2",0.0324520237811379,0,FALSE
+"HCC95","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34948,-1.04,0.389,7768,0.811,"ITGB1, ACTG1, CACNA2D1, TPM3, TGFB3, TPM2, ITGA1, ITGA7, ITGA4, ITGB5, DES, ITGB3, ACE",0.410050398674292,0.090979145788844,FALSE
+"HCC95","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42159,-1.22,0.206,6918,0.705,"PIP4K2C, PI4KA, INPP1, OCRL, INPPL1, PIP4K2A, PIP4K2B, PLCG1, PIK3C2B, ITPKB, SYNJ1, INPP4B, PIK3CB, PI4KB",0.686132779630847,0.151810883008601,FALSE
+"HCC95","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.18628,-0.55,0.988,6195,0.981,"PYGB, MAP2K1, RPS6KB1, EIF4E, RPS6, MAP2K2, PRKAR1A, PIK3R1, HK2, RHEB, PPP1R3D, TRIP10, GSK3B, AKT2, AKT3, FBP1, CBLB, MAPK1, PRKACA, GYS1, PRKAR2B, MAPK3, SOS1, AKT1, INPP5D, SORBS1, PIK3CB, CALM2, PDE3A, GCK, PRKACB",0.00524305541237188,0.0083309926200515,FALSE
+"HCC95","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.26382,-0.76,0.78,6243,0.883,"STAT1, OSM, PTPN11, EPO, CCND1, PIK3R1, STAT5B, PIM1, STAM2, SPRY2, AKT2, IL13RA2, AKT3, CBLB, STAM, SOS1, AKT1, STAT2, PIK3CB, SPRY1, SPRY4",0.10790539730952,0.0540392964224314,FALSE
+"HCC95","Input","KEGG_LEISHMANIA_INFECTION",-0.33228,-0.962,0.478,7269,0.822,"MAPK14, IRAK4, MAPK1, ITGB2, MAPK3, ITGB1, MYD88, TGFB3, PRKCB, ITGA4, CYBA, MARCKSL1",0.320572103387881,0.0851281824599496,FALSE
+"HCC95","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.3173,0.961,0.445,966,0.764,"THY1, CLDN11, JAM3, CLDN6, CLDN1, VAV1, RAC2, MAPK12, CTNND1, F11R, OCLN",0.351639989019068,0.11690664142431,FALSE
+"HCC95","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.74901,-2.14,0.00385,8438,0.218,"YOD1, ALDH9A1, ALDH7A1",2.4145392704915,0.661543506395395,TRUE
+"HCC95","Input","KEGG_LONG_TERM_DEPRESSION",-0.28569,-0.838,0.645,7341,0.845,"MAPK1, PRKCA, PRKG1, MAPK3, PPP2CB, PRKCG, PLA2G12A, PRKCB, CACNA1A",0.190440285364732,0.0731432910503077,FALSE
+"HCC95","Input","KEGG_LONG_TERM_POTENTIATION",-0.31122,-0.905,0.528,7247,0.818,"RAP1A, PPP3CC, MAPK1, PRKACA, PRKCA, RAP1B, MAPK3, PRKCG, CALM2, PPP3R1, RPS6KA3, PPP3R2, PRKACB, PRKCB",0.277366077466188,0.087246696328677,FALSE
+"HCC95","Input","KEGG_LYSINE_DEGRADATION",-0.35242,-1.03,0.39,7895,0.817,"ACAT1, DOT1L, GCDH, ALDH9A1, ALDH7A1",0.408935392973501,0.0877779434675845,FALSE
+"HCC95","Input","KEGG_LYSOSOME",-0.33836,-0.998,0.427,6094,0.804,"GGA2, SLC11A2, AP1G1, NAGPA, PLA2G15, AP3M1, PSAPL1, AP3M2, CLTB, CLTA, ARSA, ATP6AP1, FUCA1, GLB1, AP1B1, SMPD1, DNASE2, CTSC, CTSF, CLN3, AP3S1, ACP5, AP1M2, ATP6V0A2, LGMN, GGA3, AP3D1, AGA, ATP6V1H, ATP6V0A1, TCIRG1, CTSK, CTSO, AP3S2, PPT2, IGF2R, SCARB2, NAPSA, GNS, GGA1, ASAH1, MANBA, ATP6V0D1, LIPA, AP1S2, SORT1, CD63, SLC17A5, MCOLN1",0.369572124974976,0.0947439512515487,FALSE
+"HCC95","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.21082,-0.61,0.944,7247,1,"RAP1A, PPP3CC, MAPK14, MAPK1, PRKACA, PRKCA, PPP5C, CD14, RAP1B, MAPK3, ARRB2, CACNA2D1, SOS1, MAP2K7, AKT1, PRKCG, RASA2, MOS, HSPA1L, MAPKAPK2, TGFB3, MAP3K5, HSPA2, PPP3R1, MAP4K4, RPS6KA3, PPP3R2, PLA2G12A, STMN1, PRKACB, ARRB1, PRKCB, NFATC2, CACNA1A",0.025028005701931,0,FALSE
+"HCC95","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.60038,-1.78,0.0227,8205,0.24,"FOXA2, GCK, HNF1A, HNF4A",1.64397414280688,0.619788758288394,TRUE
+"HCC95","Input","KEGG_MELANOGENESIS",-0.29709,-0.863,0.619,7341,0.856,"MAPK1, PRKACA, PRKCA, MAPK3, ADCY5, PRKCG, TYR, CALM2, PRKACB, TYRP1, DCT, ADCY6, PRKCB, MITF",0.208309350979882,0.0675262353228468,FALSE
+"HCC95","Input","KEGG_MELANOMA",0.34645,1.02,0.371,1106,0.732,"EGFR, IGF1R, FGF13, FGF2, KRAS, NRAS, RB1, HRAS, BAD, MET",0.430626090384954,0.135488918941608,FALSE
+"HCC95","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.73845,2.19,0,162,0.139,"ADH4, ADH7, AKR1C2, AKR1C1, AKR1C3, CYP2S1, ALDH3A1, GSTM3",Inf,0.856985199745905,TRUE
+"HCC95","Input","KEGG_MISMATCH_REPAIR",0.64059,1.91,0.0207,2505,0.265,"MSH3, RFC2, SSBP1, POLD3, MLH1, RFC4, RFC5, POLD4, MSH2, PMS2, POLD1, RPA3, RPA2, POLD2, MSH6, RPA1",1.68402965454308,0.576754126063192,FALSE
+"HCC95","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.44542,-1.26,0.197,6130,0.641,"RPS6KA2, RPS6KB1, EIF4E, RPS6, PIK3R1, RHEB, RPS6KA6, AKT2, AKT3, MAPK1, MAPK3, AKT1, PIK3CB, RPS6KA3, ULK3",0.705533773838407,0.193141970481183,FALSE
+"HCC95","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.29347,0.864,0.608,873,0.813,"IFNGR1, MICA, VAV1, RAET1L, ULBP2, PTPN6, RAC2, KRAS, NRAS, RAC3, LAT, TNFRSF10A",0.216096420727265,0.0899094544059319,FALSE
+"HCC95","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.40838,1.22,0.216,2491,0.622,"GRIN1, NR3C1, PRSS3, F2RL1, HRH1, P2RX4, LTB4R2, CGA, CTSG, F2",0.665546248849069,0.206209615309181,FALSE
+"HCC95","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.20035,-0.579,0.956,6414,0.978,"PTPN11, MAP2K2, PIK3R1, FRS2, RPS6KA6, CAMK2D, BAX, NFKBIB, YWHAQ, GSK3B, AKT2, AKT3, RIPK2, ARHGDIA, RAP1A, MAPK14, IRAK4, ARHGDIB, MAPK1, PLCG1, RAP1B, MAPK3, SOS1, MAP2K7, AKT1, CSK, MAPKAPK2, MAP3K5, PIK3CB, CALM2, RPS6KA3, SORT1, MAGED1, PSEN1",0.0195421077238999,0.00966114521239857,FALSE
+"HCC95","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.62232,-1.85,0.0192,8340,0.244,"ENPP1, NT5E, NNMT, NNT, QPRT, BST1",1.71669877129645,0.612610173661271,TRUE
+"HCC95","Input","KEGG_NITROGEN_METABOLISM",-0.67522,-1.93,0.0152,7877,0.268,"CPS1, CA2, GLS, GLS2, CA14, CA8, GLUD2",1.81815641205523,0.571865205971211,FALSE
+"HCC95","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.38109,1.14,0.268,684,0.623,"TRAF6, CASP1, IKBKB, IL18, TRIP6, MAPK12",0.571865205971211,0.20551195334083,FALSE
+"HCC95","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.50282,1.5,0.0752,3006,0.339,"XRCC4, POLM, PRKDC, XRCC5, LIG4, FEN1",1.12378215940836,0.469800301796918,FALSE
+"HCC95","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.31675,-0.92,0.53,7718,0.827,"PLCG1, MAPK3, SOS1, AKT1, PRKCG, CDK6, PIK3CB, PRKCB, CDKN2A, RASSF5, FHIT",0.275724130399211,0.0824944904474534,FALSE
+"HCC95","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.2818,-0.83,0.645,6983,0.85,"APH1A, NCSTN, LFNG, HDAC2, CIR1, DTX3L, NOTCH2, CTBP2, PSEN2, PSEN1",0.190440285364732,0.0705810742857073,FALSE
+"HCC95","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.58293,1.71,0.0438,2715,0.286,"XPA, DDB2, ERCC5, ERCC8, RAD23B, RFC2, POLD3, RFC4, CUL4A, RFC5, ERCC1, CDK7, GTF2H1, MNAT1, POLD4, POLE, GTF2H4, ERCC4, ERCC3, POLD1, RPA3, GTF2H3, RPA2, GTF2H5, DDB1, POLE4, RBX1, POLD2, XPC, CCNH, RPA1, ERCC2, GTF2H2",1.3585258894959,0.543633966870957,FALSE
+"HCC95","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.29047,0.871,0.574,1414,0.826,"ALG13, ALG12, ST6GAL1, MAN2A1, ALG2, MGAT1, MGAT4B, B4GALT1, MAN1A1",0.241088107602027,0.0830199526796178,FALSE
+"HCC95","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.58963,-1.7,0.0386,7045,0.262,"PDC, PRKACA, PRKG1, ARRB2, CALM2, PRKACB, PDE1C",1.41341269532825,0.581698708680255,FALSE
+"HCC95","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.38196,-1.12,0.284,6210,0.705,"ATIC, MTHFS, GART, MTHFR, MTR, TYMS",0.546681659952962,0.151810883008601,FALSE
+"HCC95","Input","KEGG_OOCYTE_MEIOSIS",-0.19859,-0.581,0.969,6621,0.987,"CCNB2, PPP2R5B, RPS6KA6, CAMK2D, YWHAQ, MAD2L1, PPP2R5A, PLK1, PPP3CC, MAPK1, PRKACA, MAPK3, PPP2CB, ADCY5, MOS, SGO1, CALM2, PPP3R1, CDK2, RPS6KA3, PPP3R2, PRKACB, ADCY6",0.0136762229492347,0.00568284733036327,FALSE
+"HCC95","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.20024,-0.582,0.967,6439,1,"FUCA1, GLB1, FUCA2, AGA, MANBA",0.0145735259169983,0,FALSE
+"HCC95","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.43404,-1.3,0.169,6417,0.582,"COX7A2, ATP6AP1, COX4I1, NDUFS2, UQCRQ, NDUFA3, NDUFAB1, ATP6V1B1, PPA1, COX5A, ATP6V0A2, NDUFB4, ATP6V1F, ATP6V1H, PPA2, NDUFB7, ATP6V1B2, ATP6V1A, ATP6V1C2, COX6C, ATP6V0A1, TCIRG1, NDUFA2, ATP6V1C1, ATP6V1D, ATP6V1E1, COX7C, ATP6V1G1, ATP6V0D1, COX7B, ATP5MC2, COX17",0.772113295386326,0.235077015350112,FALSE
+"HCC95","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.46048,-1.35,0.134,7735,0.554,"GALNT6, B4GALT5, ST3GAL2, C1GALT1C1, C1GALT1, GALNT16, GALNT17",0.872895201635192,0.25649023527157,FALSE
+"HCC95","Input","KEGG_P53_SIGNALING_PATHWAY",-0.31951,-0.938,0.507,7931,0.847,"CD82, RCHY1, CDK6, CYCS, CDK2, COP1, RRM2, CDKN2A, TP53I3",0.294992040666664,0.0721165896692931,FALSE
+"HCC95","Input","KEGG_PANCREATIC_CANCER",0.24554,0.717,0.808,1105,0.878,"EGFR, IKBKB, TGFB2, RAC2, SMAD3, KRAS, RAC3, RB1, BAD",0.0925886392254138,0.0565054840938974,FALSE
+"HCC95","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.42371,1.25,0.195,320,0.608,"BCAT2, BCAT1",0.709965388637482,0.216096420727265,FALSE
+"HCC95","Input","KEGG_PARKINSONS_DISEASE",-0.2927,-0.843,0.611,6229,0.872,"COX5B, NDUFS7, PARK7, COX7A2, COX4I1, NDUFS2, UQCRQ, NDUFA3, SLC25A6, UBE2G2, NDUFAB1, UBE2G1, UBE2L6, UBE2L3, CASP3, COX5A, NDUFB4, NDUFB7, COX6C, NDUFA2, UBA1, COX7C, UBE2J1, SLC25A4, CYCS, COX7B, SLC18A1, ATP5MC2",0.213958789757446,0.0594835150674328,FALSE
+"HCC95","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.34548,-1.02,0.383,5571,0.786,"EZR, NCK2, FYN, ARPC4, TUBB1, ACTB, WASL, TUBA1B, ARPC5, TUBB3, NCL, TUBA1C, TUBB, TUBB2A, CTNNB1, YWHAQ, TUBA3C, ARPC3, ROCK1, ROCK2, ARHGEF2, TUBB6, PRKCA, HCLS1, CD14, ITGB1, ACTG1, TUBB2B",0.416801226031377,0.104577453960592,FALSE
+"HCC95","Input","KEGG_PATHWAYS_IN_CANCER",0.29121,0.865,0.578,1460,0.825,"EGFR, SLC2A1, FZD1, TRAF6, LAMA1, WNT5A, RXRA, ITGA2, ITGA6, AR, LAMB3, PML, IKBKB, ITGA3, IGF1R, FZD6, LAMC2, TGFB2, RAC2, JUN, GSTP1, FGF13, FGF2, SMAD3, LAMA5, KRAS, NRAS, RAC3, RB1, RARA, HRAS, MSH3, BAD, MET, PTGS2, MYC, MLH1, FZD2, BCL2L1, DVL3, CDKN1B, FH, STAT3",0.238072161579471,0.0835460514500749,FALSE
+"HCC95","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.30188,0.904,0.547,771,0.798,"AKR1B1, UGDH",0.262012673666569,0.0979971086492706,FALSE
+"HCC95","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.26871,-0.78,0.733,7036,0.879,"RPE, FBP1, PFKL, DERA, PFKP, RBKS, RPIA, PGM1",0.134896025358872,0.0560111249262281,FALSE
+"HCC95","Input","KEGG_PEROXISOME",-0.38494,-1.14,0.267,7196,0.721,"PEX26, PEX11A, ECI2, AMACR, ABCD4, PEX16, AGPS, ABCD3, HSD17B4, ACSL6, PEX6, SCP2, PEX12, PEX1, ABCD1, DECR2, PECR, IDH2, PEX19, ACOX3, ACOT8, ACAA1, ACSL1, HACL1, ACSL5, FAR2",0.573488738635425,0.142064735280571,FALSE
+"HCC95","Input","KEGG_PHENYLALANINE_METABOLISM",0.64089,1.89,0.0277,1060,0.244,"ALDH3A1, GOT2, MAOA",1.55752023093555,0.612610173661271,TRUE
+"HCC95","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.41044,-1.19,0.24,6918,0.656,"PIP4K2C, PI4KA, INPP1, PRKCA, OCRL, INPPL1, PIP4K2A, PIP4K2B, PLCG1, PIK3C2B, ITPKB, PRKCG, SYNJ1, INPP4B, INPP5D, PIK3CB, CALM2, PI4KB, PRKCB",0.619788758288394,0.18309616062434,FALSE
+"HCC95","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.3439,-0.998,0.434,7114,0.804,"EARS2, UROD, CPOX, PPOX, HMOX1, HCCS, UROS",0.362510270487489,0.0947439512515487,FALSE
+"HCC95","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.37255,-1.09,0.309,7286,0.752,"ACADM, GK2, SLC27A4, FABP6, FABP5, ILK, DBI, ACSL6, FABP3, SCP2, SORBS1, FABP4, ACOX3, GK, ACAA1, ACSL1, CYP27A1, ACSL5",0.510041520575165,0.123782159408358,FALSE
+"HCC95","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.46461,1.4,0.103,37,0.438,"AKR1D1",0.987162775294828,0.3585258894959,FALSE
+"HCC95","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.31845,0.934,0.512,1341,0.777,"CD40, TAP1, TAP2",0.290730039024169,0.109578981199086,FALSE
+"HCC95","Input","KEGG_PRION_DISEASES",0.33232,0.976,0.442,563,0.762,"C9, PRNP",0.354577730650908,0.1180450286604,FALSE
+"HCC95","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.21599,-0.627,0.937,6530,1,"PIK3R1, CCNB2, RPS6KA6, AKT2, MAD2L1, PLK1, AKT3, MAPK14, MAPK1, PRKACA, MAPK3, ADCY5, AKT1, MOS, PIK3CB, CDK2, PDE3A, RPS6KA3, PRKACB, ADCY6",0.0282604091122217,0,FALSE
+"HCC95","Input","KEGG_PROPANOATE_METABOLISM",-0.46237,-1.31,0.181,7870,0.585,"LDHA, ACAT1, SUCLG2, ACSS3, ALDH9A1, ALDH7A1",0.742321425130815,0.23284413391782,FALSE
+"HCC95","Input","KEGG_PROSTATE_CANCER",0.37258,1.08,0.312,1105,0.69,"EGFR, AR, IKBKB, IGF1R, GSTP1, KRAS, NRAS, RB1, ATF4, HRAS, BAD",0.505845405981557,0.161150909262745,FALSE
+"HCC95","Input","KEGG_PROTEASOME",0.52184,1.53,0.0689,3172,0.359,"PSMB9, PSMB8, PSMB10, PSME1, PSMB4, PSME2, PSME4, POMP, PSMB3, PSMB7, PSMA4, PSME3, PSMA8, PSMC2, PSMA2, PSMF1, PSMB2, PSMA6, PSMB5, PSMA1, PSMD12, PSMD4, PSMC4, PSMA7, PSMB1, PSMC3, PSMC5, PSMC1",1.16178077809237,0.444905551421681,FALSE
+"HCC95","Input","KEGG_PROTEIN_EXPORT",-0.28253,-0.842,0.622,7078,0.849,"SPCS2, SEC11A, IMMP1L, SEC11C",0.206209615309181,0.0710923097560473,FALSE
+"HCC95","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.39349,-1.17,0.231,7991,0.677,"CA2, GLS, GLS2, GLUD2",0.636388020107856,0.169411331314856,FALSE
+"HCC95","Input","KEGG_PURINE_METABOLISM",-0.36054,-1.08,0.308,7213,0.756,"AK2, AMPD2, APRT, NPR1, POLA2, GDA, PDE4D, POLA1, ADCY5, GMPR, PRUNE1, AK1, ENPP1, PDE3A, NPR2, PAPSS2, RRM2, NT5E, ADCY6, NME4, FHIT, PDE4A, PDE1C",0.511449283499556,0.121478204498793,FALSE
+"HCC95","Input","KEGG_PYRIMIDINE_METABOLISM",-0.27985,-0.802,0.69,7477,0.883,"POLA2, TYMP, CMPK1, CTPS1, UMPS, POLA1, TYMS, CTPS2, RRM2, NT5E, NME4, TK1, TK2",0.161150909262745,0.0540392964224314,FALSE
+"HCC95","Input","KEGG_PYRUVATE_METABOLISM",-0.40539,-1.19,0.238,7239,0.656,"PDHA1, ACYP2, PDHB, HAGH, LDHA, ACAT1, ME3, ACYP1, ALDH9A1, ALDH7A1",0.623423042943488,0.18309616062434,FALSE
+"HCC95","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.23428,0.692,0.843,733,0.904,"EGFR, ITGB4, PFN2, ITGA2, IQGAP2, ITGA6, VAV1, ITGA5, ITGA3, RAC2, GNA13, ITGB8, FGF13, FGF2, KRAS, NRAS, RAC3",0.0741724253752577,0.0438315695246367,FALSE
+"HCC95","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.62807,-1.82,0.0378,6893,0.22,"ATG4C, ATG4A, GABARAPL1, ATG4B, ATG3, ULK3, GABARAPL2",1.42250820016277,0.657577319177794,TRUE
+"HCC95","Input","KEGG_RENAL_CELL_CARCINOMA",0.20618,0.614,0.944,1106,0.967,"SLC2A1, TGFB2, JUN, KRAS, NRAS, HRAS, MET",0.025028005701931,0.0145735259169983,FALSE
+"HCC95","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.55799,-1.64,0.0375,7272,0.288,"MME, ANPEP, CPA3, ACE",1.42596873227228,0.540607512240769,FALSE
+"HCC95","Input","KEGG_RETINOL_METABOLISM",0.71108,2.08,0.00416,314,0.178,"ADH4, ADH7, DHRS3",2.38090666937326,0.749579997691106,TRUE
+"HCC95","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.65588,-1.88,0.018,6852,0.28,"ACP1, ACP5, PHPT1, TYR, MTMR6, ENPP1",1.74472749489669,0.552841968657781,FALSE
+"HCC95","Input","KEGG_RIBOSOME",0.2264,0.66,0.902,3922,0.933,"RPL22L1, RPL37, RPL29, RPL26L1, RPL32, RPL4, RPS27A, RPL37A, RPL14, RPL27, RPL24, RSL24D1, RPSA, RPL34, RPS12, RPS16, RPL36A, RPL36AL, RPL35A, RPL27A, RPL7A, RPL35, RPL13A, RPS3A, RPL10A, FAU, RPS8, RPS11, RPS15A, UBA52, RPS3, RPL21, RPL19, RPL36, RPL23, RPL23A, RPLP0, RPS26, RPL30",0.0447934624580583,0.0301183562535,FALSE
+"HCC95","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.27389,-0.79,0.723,5873,0.895,"ATG12, MAPK8, TKFC, TBK1, FADD, MAP3K7, PIN1, DHX58, NFKBIB, IRF3, CYLD, OTUD5, MAPK14, TRAF3, DDX58, ISG15, RIPK1, DDX3Y",0.140861702705469,0.048176964684088,FALSE
+"HCC95","Input","KEGG_RNA_DEGRADATION",0.2515,0.754,0.745,3336,0.851,"PAPOLG, EXOSC1, LSM4, DIS3, EXOSC3, EXOSC8, EXOSC6, EXOSC9, PARN, EXOSC4, LSM6, EXOSC5, C1D, HSPA9, SKIV2L, PNPT1, CNOT6, XRN2, EXOSC2, LSM3, MTREX, EDC3, EXOSC7, LSM8, XRN1, ZCCHC7, LSM7, LSM2, TTC37",0.127843727251707,0.0700704399154121,FALSE
+"HCC95","Input","KEGG_RNA_POLYMERASE",0.24366,0.725,0.834,6706,0.888,"POLR3G, POLR1E, POLR1B, POLR1A, POLR2G, POLR2K, POLR1C, POLR1D, POLR2J, POLR2L, POLR2E, POLR2I, POLR2A, POLR2D, POLR2C, POLR3C, POLR2B, POLR2F, POLR3H, POLR3F, POLR3K, POLR3A, POLR3D, POLR2H, POLR3B, POLR3GL",0.0788339493622613,0.051587034221399,FALSE
+"HCC95","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.25909,0.764,0.734,1348,0.845,"BUD23, SCLY, MAT1A, METTL2B, MAT2B",0.134303940083929,0.0731432910503077,FALSE
+"HCC95","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.30067,0.871,0.577,431,0.826,"TRAF6, LAMA1, RXRA, ITGA2, ITGA6, LAMB3, IKBKB, ITGA3, LAMC2",0.238824186844269,0.0830199526796178,FALSE
+"HCC95","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.48851,-1.45,0.0839,6947,0.432,"STX18, STX6, VTI1B, VTI1A, SNAP47, SEC22B, SNAP29, VAMP7, VAMP4, STX12, YKT6, STX7, STX3",1.0762380391713,0.364516253185088,FALSE
+"HCC95","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33855,1.01,0.396,1337,0.721,"PLPP1, KDSR, GLA, GALC, NEU3, SGPL1, UGT8",0.402304814074488,0.142064735280571,FALSE
+"HCC95","Input","KEGG_SPLICEOSOME",0.27153,0.806,0.711,3431,0.794,"DHX8, NCBP1, DHX38, CRNKL1, SLU7, LSM4, DDX42, EFTUD2, SNU13, HSPA1A, TXNL4A, LSM6, PRPF6, PRPF38A, PRPF19, AQR, SNRPB, HSPA6, PPIE, ZMAT2, BCAS2, PPIL1, DDX46, PRPF18, THOC3, ISY1, CCDC12, SF3A2, SNRPD3, EIF4A3, SNRPF, NCBP2, SNRNP200, LSM3, PRPF8, TCERG1, HNRNPK, SF3B5, PLRG1, DDX39B, USP39, SNRPG, SNRPD1, SNRPD2, PRPF40B, LSM8, SF3B6, SF3A1, SNW1, HNRNPA3, ALYREF, SNRNP70, DDX23, SMNDC1, THOC2, LSM7, LSM2, CDC5L, SF3B1, TRA2B, SF3A3, DDX5, SNRNP40, HNRNPC, SNRPC",0.148130399270234,0.100179497572904,FALSE
+"HCC95","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.29046,-0.842,0.629,7465,0.849,"GYS1, GBE1, ENPP1, GCK, PGM1",0.201349354554731,0.0710923097560473,FALSE
+"HCC95","Input","KEGG_STEROID_BIOSYNTHESIS",-0.38885,-1.13,0.285,7136,0.702,"HSD17B7, CYP51A1, SOAT1, TM7SF2, CEL, LIPA",0.54515513999149,0.153662887870195,FALSE
+"HCC95","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.79115,2.32,0,37,0.111,"AKR1C2, AKR1C1, AKR1C3, AKR1D1",Inf,0.954677021213343,TRUE
+"HCC95","Input","KEGG_SULFUR_METABOLISM",-0.75757,-2.24,0.00377,8250,0.229,"CHST11, PAPSS2, SULT1A3, SULT1A1",2.42365864979421,0.640164517660112,TRUE
+"HCC95","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.68017,2.01,0.011,224,0.199,"C9, C3, CD40",1.95860731484178,0.701146923590293,TRUE
+"HCC95","Input","KEGG_TASTE_TRANSDUCTION",-0.6437,-1.85,0.0264,8551,0.244,"PRKACB, ADCY6, CACNA1A",1.57839607313017,0.612610173661271,TRUE
+"HCC95","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.54274,-1.59,0.0586,7115,0.276,"IDI1, HMGCR, MVD, FDPS, ACAT1",1.23210238398191,0.559090917934782,FALSE
+"HCC95","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.30931,-0.91,0.536,7152,0.835,"ROCK1, ROCK2, SMAD5, MAPK1, MAPK3, PPP2CB, TGFB3, ZFYVE9, INHBE, SMAD2",0.27083521030723,0.0783135245163979,FALSE
+"HCC95","Input","KEGG_THYROID_CANCER",0.28918,0.854,0.617,1129,0.807,"RXRA, KRAS, NRAS, HRAS, MYC",0.209714835966758,0.0931264652779296,FALSE
+"HCC95","Input","KEGG_TIGHT_JUNCTION",0.28629,0.831,0.619,1088,0.804,"CLDN11, JAM3, MYH4, CLDN6, CLDN1, YES1, EPB41L1, YBX3, KRAS, NRAS, PATJ, SRC, F11R, OCLN, HRAS, ACTN4",0.208309350979882,0.0947439512515487,FALSE
+"HCC95","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.29647,-0.861,0.607,6156,0.847,"TLR9, MAP2K1, STAT1, TBK1, FADD, MAP3K7, MAP2K2, PIK3R1, MAP2K3, MAP2K4, AKT2, IRF3, AKT3, MAPK14, IRAK4, MAPK1, TRAF3, TOLLIP, CD14, CTSK, MAPK3, MAP2K7, AKT1, MYD88, PIK3CB, RIPK1",0.216811308924742,0.0721165896692931,FALSE
+"HCC95","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.38548,-1.13,0.274,7805,0.702,"KMO, ACAT1, GCDH, ALDH9A1, ALDH7A1",0.562249437179612,0.153662887870195,FALSE
+"HCC95","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.28783,0.842,0.603,498,0.806,"PDX1, ABCC8, IKBKB, IRS1",0.219682687859849,0.0936649581949093,FALSE
+"HCC95","Input","KEGG_TYROSINE_METABOLISM",0.54225,1.63,0.0553,1060,0.301,"ADH4, ADH7, ALDH3A1, BUD23, GOT2, METTL2B, MAOA",1.2572748686953,0.521433504406157,FALSE
+"HCC95","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.26284,-0.779,0.741,6772,0.87,"NFKBIB, GSK3B, AKT2, NFAT5, AKT3, PPP3CC, MAPK14, CBLB, MAPK1, PLCG1, MAPK3, SOS1, MAP2K7, AKT1, PIK3CB, PPP3R1, PPP3R2, NFATC2, PTPRC, GRAP2",0.130181792020672,0.0604807473813815,FALSE
+"HCC95","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.18932,0.555,0.975,1462,0.98,"TRAF6, PML, UBE2H, DDB2, CDC23, ANAPC4, CDC16, ANAPC7, FBXO4, NEDD4, ANAPC5, CDC26, ERCC8, CDC27, CUL4A, UBE2Z, FBXO2, UBE3C, FBXW11, ANAPC1",0.0109953843014632,0.00877392430750515,FALSE
+"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.61955,1.86,0.0339,320,0.24,"BCAT2, BCAT1",1.46980030179692,0.619788758288394,TRUE
+"HCC95","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.31255,-0.927,0.499,7895,0.826,"ACAT1, ACAA2, HSD17B10, ALDH9A1, ACAA1, ALDH7A1",0.30189945437661,0.0830199526796178,FALSE
+"HCC95","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.48012,-1.38,0.153,7096,0.522,"ARHGEF1, ROCK1, ROCK2, PRKCE, MAPK1, PRKACA, PRKCA, NPR1, PRKG1, MAPK3, ADCY5, PRKCG, PPP1R12B, ARHGEF11, KCNMA1, MYLK, CALM2, CALD1, NPR2, PLA2G12A, PRKACB, ADCY6, PRKCB",0.815308569182401,0.282329496997738,FALSE
+"HCC95","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.40177,-1.2,0.231,5979,0.701,"RAB5C, DCTN4, DCTN1, NSF, CREB5, RAB11A, DCTN2, ARHGDIA, ARHGDIB, PRKACA, RAB5B, DYNC1LI1, RAB5A, RAB11B, PRKACB, ADCY6",0.636388020107856,0.154281982033341,FALSE
+"HCC95","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32187,-0.937,0.514,6854,0.834,"AKT2, NFAT5, MAPKAPK3, AKT3, PPP3CC, MAPK14, MAPK1, PRKCA, PLCG1, MAPK3, AKT1, PRKCG, MAPKAPK2, PIK3CB, PPP3R1, PPP3R2, PLA2G12A, PRKCB, NFATC2, SPHK2",0.289036881004724,0.0788339493622613,FALSE
+"HCC95","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.58265,-1.71,0.0353,7120,0.271,"ATP6V0A2, ATP6V1F, ATP6V1H, PRKACA, PRKCA, ATP6V1B2, ATP6V1A, ATP6V1C2, ATP6V0A1, TCIRG1, ATP6V1C1, ATP6V1D, PLCG1, KDELR3, ATP6V1E1, ACTG1, ATP6V1G1, PRKCG, TJP2, ATP6V0D1, PRKACB, PRKCB",1.45222529461218,0.567030709125594,FALSE
+"HCC95","Input","KEGG_VIRAL_MYOCARDITIS",0.36306,1.06,0.35,733,0.716,"CAV1, MYH4, CD40, RAC2, RAC3",0.455931955649724,0.145086977692144,FALSE
+"HCC95","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24695,-0.712,0.835,6641,0.942,"PPP2R5B, CAMK2D, CTNNB1, DAAM2, WNT11, CXXC4, GSK3B, NFAT5, PPP2R5A, ROCK1, ROCK2, PPP3CC, CACYBP, PRKACA, PRKCA, DAAM1, PPP2CB, CTBP2, PRKCG, VANGL2, NKD1, NKD2, FOSL1, PPP3R1, PPP3R2, PRKACB, PRKCB, NFATC2, PSEN1, SMAD2",0.0783135245163979,0.0259490972071227,FALSE
+"H1650","Input","KEGG_ABC_TRANSPORTERS",-0.42713,-1.35,0.139,7453,0.451,"ABCC10, ABCC2, ABCD4, ABCA10, ABCB1, ABCA3, ABCC5, ABCB6, ABCC4, ABCB4",0.856985199745905,0.345823458122039,FALSE
+"H1650","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.18586,-0.575,0.971,7475,0.985,"STAT5A, STAT5B, PIM1, IKBKB, EIF4EBP1, MYC",0.0127807700919951,0.00656376950238827,FALSE
+"H1650","Input","KEGG_ADHERENS_JUNCTION",0.37331,1.15,0.26,2728,0.466,"ERBB2, CTNNA1, CTNNB1, NECTIN1, TGFBR2, CTNND1, CTNNA2, EGFR, PTPRM, SMAD3, PTPRJ, PTPRF, MAPK3, MAP3K7, NECTIN2, CDH1, BAIAP2, ACTN4, PTPN1, CREBBP, EP300, ACTG1, SRC, CDC42, SMAD2, RAC1, NECTIN4, FYN, ACTN1, CSNK2A1, CSNK2A2, VCL, ACTB, RHOA, PTPN6",0.585026652029182,0.33161408331,FALSE
+"H1650","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.44472,1.36,0.138,2213,0.358,"CD36, PRKCQ, RXRA, SLC2A1, ACSL1, TRADD, ACSL5, ACSL6, STAT3, AKT2, AKT3, PRKAA1, MTOR, CHUK, ACACB, CPT1A, NFKB1",0.860120913598763,0.446116973356126,FALSE
+"H1650","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.49748,1.5,0.0606,1055,0.344,"ABAT, GLUL, ASS1, GLS, GLS2, GPT2",1.21752737583371,0.46344155742847,FALSE
+"H1650","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.32604,1,0.398,1661,0.61,"ATP1B3, SFN, ATP1B1, MAPK3, ATP1A3, PIK3R3, ATP1A1, ATP1A4, PRKCA",0.400116927926312,0.214670164989233,FALSE
+"H1650","Input","KEGG_ALZHEIMERS_DISEASE",0.19217,0.584,0.977,1731,0.991,"NDUFA2, PPP3R2, MME, PPP3R1, CAPN2, PPP3CA, CAPN1, PPP3CB, CYC1, UQCR10, SDHD, ITPR2, FAS, GAPDH, CASP7, MAPK3, ATP2A2, EIF2AK3, SDHC, CYCS, GNAQ, COX6A1, CASP8",0.0101054362812269,0.00392634551472468,FALSE
+"H1650","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.45506,-1.4,0.111,6631,0.439,"MARS2, MTFMT, PARS2, HARS2, AARS2, NARS2, CARS2, TARS2, WARS2",0.954677021213343,0.357535479757879,FALSE
+"H1650","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.24495,0.76,0.79,1750,0.856,"PGM1, MPI, NAGK, GNE, UGP2, UAP1, CYB5R3, GMPPB, GMPPA, HEXA, HK1",0.102372908709559,0.0675262353228468,FALSE
+"H1650","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.30793,-0.953,0.493,8445,0.694,"NEFH, NEFM, PRPH, PRPH2, NEFL, TP53",0.30715308072277,0.158640529545145,FALSE
+"H1650","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.60892,1.87,0.018,1015,0.205,"CD74, HSPA2, HSPA1L, TAPBP, CTSL, B2M, TAP1, HSPA6, TAP2",1.74472749489669,0.688246138944246,TRUE
+"H1650","Input","KEGG_APOPTOSIS",0.39026,1.2,0.204,1731,0.435,"PPP3R2, ENDOD1, PPP3R1, PRKACB, CAPN2, PPP3CA, CAPN1, PPP3CB, PRKAR1B, TRADD, ENDOG, PRKAR1A, FAS, MYD88, CASP7, AKT2, AKT3, PIK3R3, CYCS, PRKACA, CASP8",0.690369832574101,0.361510743045363,FALSE
+"H1650","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.45723,1.41,0.111,485,0.348,"PTGES, GGT1, CYP4F3, GPX6, GPX7",0.954677021213343,0.458420756053419,FALSE
+"H1650","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.29352,0.881,0.575,1107,0.72,"GLUL, ALDH7A1, GATM, P4HA1, PYCR3, ASS1, AOC1, DAO, GLS, GLS2, OAT, P4HA2",0.24033215531037,0.142667503568732,FALSE
+"H1650","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.46079,1.43,0.106,1475,0.354,"ITGA4, ITGA6, ITGA3, ITGB4, ITGA1, ITGB1, ITGA2, ITGA5, SLC8A1, CTNNA1, CTNNB1, ITGB5, DSC2, CTNNA2, DSG2, DAG1, ITGAV, ITGB8, PKP2, ACTN4, ATP2A2, LMNA",0.97469413473523,0.450996737974212,FALSE
+"H1650","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.57795,-1.8,0.0182,8393,0.32,"UGDH, ALDH2, ALDH1B1",1.73992861201493,0.494850021680094,FALSE
+"H1650","Input","KEGG_AXON_GUIDANCE",0.25901,0.789,0.744,1221,0.837,"ITGB1, PPP3R2, EPHB2, NFAT5, PPP3R1, SEMA3C, EFNA5, PPP3CA, PPP3CB, EPHB4, NTN4, SEMA4B, PTK2, SRGAP2, SRGAP3, RASA1, LIMK2, CFL2, MAPK3",0.128427064454121,0.07727454200674,FALSE
+"H1650","Input","KEGG_BASAL_CELL_CARCINOMA",0.44841,1.35,0.162,763,0.362,"FZD2, FZD1, CTNNB1, APC",0.790484985457369,0.441291429466834,FALSE
+"H1650","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.57937,-1.81,0.026,6190,0.383,"TAF12, GTF2E1, TAF7, TAF10, TAF9, GTF2E2, GTF2IRD1, GTF2H3, GTF2H4, GTF2H2, GTF2H1, GTF2F2, GTF2F1, TAF9B",1.58502665202918,0.416801226031377,FALSE
+"H1650","Input","KEGG_BASE_EXCISION_REPAIR",-0.49377,-1.52,0.102,7094,0.341,"MBD4, POLE3, APEX1, MPG, FEN1, PARP1, PARP2, HMGB1, POLB",0.991399828238082,0.467245621007502,FALSE
+"H1650","Input","KEGG_BETA_ALANINE_METABOLISM",0.43588,1.33,0.146,330,0.372,"ABAT, ALDH7A1",0.835647144215563,0.429457060118102,FALSE
+"H1650","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.76918,2.35,0,966,0.0462,"ACOT4, SCD5, ACOT1, ACOX3, FADS2, SCD, ACOT2, ACAA1, TECR, ACOX1",Inf,1.33535802444387,TRUE
+"H1650","Input","KEGG_BLADDER_CANCER",-0.35229,-1.07,0.343,8588,0.58,"E2F3, RB1, TP53, MYC",0.464705879957229,0.236572006437063,FALSE
+"H1650","Input","KEGG_BUTANOATE_METABOLISM",0.31998,0.971,0.459,2397,0.647,"ABAT, ALDH7A1, ALDH3A2, OXCT1, AKR1B10, ACAT2, AACS, HMGCS1, ALDH5A1, EHHADH",0.338187314462739,0.1890957193313,FALSE
+"H1650","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31122,0.971,0.475,1393,0.647,"PPP3R2, NFAT5, MALT1, PPP3R1, PPP3CA, PPP3CB, VAV2, MAPK3, AKT2, AKT3, PIK3R3, SOS1",0.323306390375133,0.1890957193313,FALSE
+"H1650","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.47802,1.46,0.0847,1687,0.327,"GNA15, CAMK2G, ERBB4, BST1, PPP3R2, CAMK2B, ERBB2, PTK2B, PPP3R1, PRKACB, SLC8A1, PPP3CA, PPP3CB, PLCD1, PHKB, PHKA1, CAMK2D, EGFR, ATP2B1, TACR1, ITPR2, GNAS, ATP2B2, ATP2B4, ADCY3, ADCY8, P2RX4, SPHK2, VDAC2, ATP2A2, TNNC1, PRKACA, PRKCA, GNAQ",1.07211658966929,0.485452247339714,FALSE
+"H1650","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.5211,1.58,0.0716,2768,0.329,"TPM2, SLC8A1, CYC1, UQCR10, TPM1, SLC9A6, SLC9A1, ATP1B3, ATP1B1, ATP1A3, ATP2A2, ATP1A1, ATP1A4, TNNC1, COX6A1, UQCRC2, UQCRFS1, CACNA2D2, UQCRC1, UQCRQ, COX6B1, COX7A2, COX7A2L, COX4I1, UQCRH, TPM4",1.14508697769214,0.482804102050026,FALSE
+"H1650","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.50982,1.53,0.0765,1325,0.348,"ITGA4, CD40, SDC1, CLDN6, SDC4, ITGA6, ITGB2, CD99, GLG1, ITGB1, CLDN4, CD274, CDH15, CDH3, F11R, SDC2, NECTIN1, OCLN, PVR, SDC3, ITGAV, PTPRM, CD276, PTPRF, ITGB8, NECTIN2, CDH1",1.11633856484638,0.458420756053419,FALSE
+"H1650","Input","KEGG_CELL_CYCLE",-0.3834,-1.2,0.217,6889,0.49,"ORC4, MCM5, CDK7, ORC5, MCM2, MCM4, CDK6, STAG1, ORC3, MCM6, MCM7, CDKN2C, TGFB2, ORC1, TGFB3, MCM3, ORC2, HDAC2, ATM, ORC6, TFDP1, CDC20, ABL1, E2F3, RB1, TP53, MYC, CDKN1B",0.66354026615147,0.309803919971486,FALSE
+"H1650","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.35263,1.06,0.348,1817,0.54,"STAT1, STAT2, PTK2B, PRKACB, ADCY6, TIAM1, ADCY5, PRKCD, PRKCZ, CCL15, VAV2, PTK2, ADCY3, ADCY8, GNG10, STAT3, TIAM2, MAPK3, ARRB1, AKT2, AKT3, PIK3R3, SOS1, PXN, CXCL6, GNG12, LYN, PRKACA, CXCR4, GNG5, ROCK1, RAP1A",0.458420756053419,0.267606240177031,FALSE
+"H1650","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.41892,-1.3,0.158,7475,0.449,"STAT5A, CTBP1, TGFB2, STAT5B, TGFB3, TGFBR1, HDAC2, IKBKB, ABL1, E2F3, RB1, GAB2, TP53, MYC, CDKN1B",0.801342913045577,0.347753658996677,FALSE
+"H1650","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.34031,1.06,0.332,2573,0.54,"SDHD, ACLY, OGDHL, PC, SDHC, OGDH, ACO2, SUCLG2, SDHB, IDH1, MDH1, DLD, SDHA, IDH2",0.478861916295964,0.267606240177031,FALSE
+"H1650","Input","KEGG_COLORECTAL_CANCER",-0.21185,-0.654,0.885,7444,0.931,"MAPK8, TGFB2, TGFB3, TGFBR1, JUN, TP53, MYC",0.0530567293021746,0.0310503190186574,FALSE
+"H1650","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.36354,1.12,0.282,973,0.491,"SERPINA1, PLAU, CD59, F8, CD55, PROC, C3, MBL2, PLAUR",0.549750891680639,0.308918507877032,FALSE
+"H1650","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.53674,-1.68,0.0463,7781,0.282,"MPST, APIP, AMD1, CTH, MTAP",1.33441900898205,0.549750891680639,FALSE
+"H1650","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.428,1.32,0.162,1738,0.361,"CD40, IFNGR1, IL18, TGFBR2, CCL15, KITLG, EGFR, LTBR, FAS, TNFRSF12A, HGF, CXCL6, FLT3, CXCR4, EPO",0.790484985457369,0.442492798094342,FALSE
+"H1650","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.40082,1.25,0.185,640,0.407,"DDX58, CASP1, IL18, IRF3, ZBP1",0.732828271596986,0.39040559077478,FALSE
+"H1650","Input","KEGG_DILATED_CARDIOMYOPATHY",0.48962,1.46,0.0892,1200,0.327,"ITGA4, ITGA6, ITGA3, ITGB4, TPM2, ITGA1, ITGB1, ITGA2, ITGA5, PRKACB, ADCY6, SLC8A1, ITGB5, ADCY5, TPM1, DAG1, GNAS, ITGAV, ADCY3, ADCY8, ITGB8",1.04963514562388,0.485452247339714,FALSE
+"H1650","Input","KEGG_DNA_REPLICATION",-0.53658,-1.65,0.0369,5305,0.283,"SSBP1, POLD3, RFC2, RFC3, RFC5, RPA3, POLD2, RPA2, RPA1, RNASEH1, DNA2, PRIM1, RFC1, POLA1, MCM5, RFC4, MCM2, MCM4, POLE3, MCM6, PRIM2, MCM7, POLA2, FEN1, MCM3, RNASEH2A, RNASEH2C, RNASEH2B",1.43297363384094,0.54821356447571,FALSE
+"H1650","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.48056,1.46,0.0809,2564,0.327,"EGFR, NOTCH3, MAPK3, SOS1, NOTCH2, SPIRE1",1.09205147838773,0.485452247339714,FALSE
+"H1650","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.588,-1.85,0.0136,7630,0.437,"ADH4, ADH7, GSTZ1, FMO3, ALDH3A1, GSTM4, ADH1C, GSTM3, MAOA, GSTM2, GSTM1, GSTP1",1.86646109162978,0.359518563029578,FALSE
+"H1650","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.37646,1.14,0.269,1024,0.474,"CDA, TYMP, TK1, TK2, CES1, CES2",0.570247719997592,0.324221658325915,FALSE
+"H1650","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.52697,1.57,0.0639,1250,0.326,"ITGA4, SDC1, SDC4, ITGA6, ITGA3, ITGB4, CD36, ITGA1, ITGB1, LAMA5, ITGA2, ITGA5, SDC2, ITGB5, LAMA3, LAMA4, DAG1, SDC3, ITGAV, LAMB1, ITGB8, COL5A1",1.1944991418416,0.486782399932061,FALSE
+"H1650","Input","KEGG_ENDOCYTOSIS",0.52654,1.65,0.0466,2260,0.308,"DNM3, HSPA2, TRAF6, EHD2, HSPA1L, EPN3, ERBB4, ASAP3, DAB2, EHD1, RAB31, PLD2, ASAP2, DNAJC6, PRKCZ, RAB11FIP5, RAB11A, EHD3, LDLRAP1, EGFR, HSPA6, AP2A1, PRKCI, SH3GLB2, PARD6B, ITCH, WWP1, PARD6G, RAB22A, AP2B1, TFRC, PSD, AP2S1, AP2M1, IQSEC1, ARRB1, PIKFYVE, VPS4A, EPN1, DNM1, VPS4B, ASAP1, RAB11B, NEDD4, PDCD6IP, HSPA1A, CHMP5, VPS45, CXCR4, SH3KBP1, RAB11FIP2, USP8, CBLB, EHD4, CLTC, SRC, ARF6, RBSN, CDC42, CHMP2A, EPN2, DNM2, RAB5B, RAB5C, ARFGAP1, ARFGAP3, VPS37B, STAMBP, RUFY1, EPS15, RAB4A",1.33161408331,0.511449283499556,FALSE
+"H1650","Input","KEGG_ENDOMETRIAL_CANCER",0.38149,1.17,0.237,1393,0.457,"ERBB2, CTNNA1, CTNNB1, CTNNA2, APC, EGFR, MAPK3, AKT2, CDH1, AKT3, PIK3R3, SOS1",0.625251653989896,0.34008379993015,FALSE
+"H1650","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.27897,-0.85,0.588,6538,0.729,"ATP6V1B2, ATP6V0A2, PAK1, ATP6V1A, ATP6V1D, ATP6V1F, GIT1, MAPK8, ATP6V1G1, ATP6V1H, ATP6V1B1, IKBKB, JUN, JAM3",0.230622673923862,0.137272471682025,FALSE
+"H1650","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.22638,0.683,0.866,1393,0.919,"CAMK2G, ERBB4, CAMK2B, ERBB2, CAMK2D, PTK2, EGFR, GAB1, MAPK3, AKT2, AKT3, PIK3R3, SOS1",0.0624821079826534,0.0366844886138887,FALSE
+"H1650","Input","KEGG_ETHER_LIPID_METABOLISM",0.63829,1.97,0.00904,1323,0.147,"PLPP3, PLD2, LPCAT2, LPCAT4, PAFAH2, PLPP1, LPCAT1",2.04383156952464,0.832682665251824,TRUE
+"H1650","Input","KEGG_FATTY_ACID_METABOLISM",0.28502,0.894,0.558,1307,0.718,"ACOX3, ALDH7A1, ACSL1, ACSL5, ACAA1, ACOX1, ACSL6, ALDH3A2",0.253365801062421,0.1438755557577,FALSE
+"H1650","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.2185,0.69,0.873,2710,0.925,"PRKCD, VAV2, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SOS1, PRKCE, MAPK14, LYN, PRKCA, MAPK13, PLCG2, RAC1, FYN, HRAS, AKT1, MAP2K6, PLA2G12A, PIK3CB",0.0589857562944303,0.0338582672609674,FALSE
+"H1650","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.3819,1.17,0.246,1661,0.457,"PLPP3, DNM3, ASAP3, PLD2, ASAP2, PRKCD, AMPH, VAV2, LIMK2, VASP, CFL2, PLPP1, MAPK3, GSN, PIKFYVE, AKT2, DNM1, AKT3, PIK3R3, SPHK2, ASAP1, PRKCE, LYN, ARPC1B, PRKCA",0.609064892896621,0.34008379993015,FALSE
+"H1650","Input","KEGG_FOCAL_ADHESION",0.38179,1.19,0.238,1958,0.442,"ITGA4, ITGA6, ITGA3, ITGB4, CAV2, CAV1, ITGA1, ITGB1, ARHGAP35, ERBB2, LAMA5, ITGA2, ITGA5, CAPN2, CTNNB1, ITGB5, FLNC, LAMA3, LAMA4, VAV2, PTK2, EGFR, ITGAV, LAMB1, VASP, ITGB8, MAPK3, COL5A1, AKT2, ACTN4, AKT3, PIK3R3, HGF, SOS1, PXN, MYL9, TNC, PRKCA, ROCK1, RAP1A, MYL12A, ACTG1, SRC, FLT4, CDC42",0.623423042943488,0.354577730650908,FALSE
+"H1650","Input","KEGG_FOLATE_BIOSYNTHESIS",0.70452,2.2,0.00185,12,0.0797,"ALPI, ALPP",2.73282827159699,1.09854167860389,TRUE
+"H1650","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.25161,0.779,0.74,2497,0.839,"MPI, PFKFB4, AKR1B1, PFKP, PFKFB2, GMPPB, MTMR1, GMPPA, AKR1B10, HK1, PFKL, PMM2, ALDOA, PHPT1, HK2",0.130768280269024,0.0762380391712997,FALSE
+"H1650","Input","KEGG_GALACTOSE_METABOLISM",0.42858,1.28,0.162,998,0.396,"PGM1, B4GALT1, UGP2, GLB1, AKR1B1, PFKP",0.790484985457369,0.402304814074488,FALSE
+"H1650","Input","KEGG_GAP_JUNCTION",0.3026,0.938,0.478,2086,0.664,"PRKACB, ADCY6, ADCY5, TUBA4A, EGFR, ITPR2, GNAS, ADCY3, ADCY8, MAPK3, SOS1, PRKACA, PRKCA, GNAQ, CDK1, SRC, MAPK7, GNA11",0.320572103387881,0.177831920631982,FALSE
+"H1650","Input","KEGG_GLIOMA",-0.27733,-0.862,0.568,8588,0.722,"E2F3, CALM2, RB1, CALML3, TP53",0.245651664288981,0.141462802430361,FALSE
+"H1650","Input","KEGG_GLUTATHIONE_METABOLISM",-0.31026,-0.945,0.464,7811,0.674,"GPX4, GSTZ1, GCLC, GPX3, GSTM4, GSTM3, GPX2, GSTM2, GSTM1, GSTP1",0.333482019445119,0.17134010346468,FALSE
+"H1650","Input","KEGG_GLYCEROLIPID_METABOLISM",0.42595,1.32,0.136,1307,0.361,"PLPP3, MGLL, DGKA, CEL, ALDH7A1, MBOAT2, AKR1B1, AGPAT4, PLPP1, ALDH3A2",0.866461091629782,0.442492798094342,FALSE
+"H1650","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40271,1.21,0.203,1709,0.435,"PLPP3, PEMT, DGKA, MBOAT7, PLD2, LPCAT2, LPCAT3, LPCAT4, MBOAT2, PLA2G15, AGPAT4, PISD, PLPP1, LPCAT1, DGKB, CDS1, AGPAT2",0.692503962086787,0.361510743045363,FALSE
+"H1650","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.2957,-0.899,0.549,6701,0.705,"GLDC, CHDH, GAMT, SHMT2, PSPH, PIPOX, MAOA, CTH",0.260427655549908,0.151810883008601,FALSE
+"H1650","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.263,-0.806,0.683,7561,0.793,"PGK2, ADH4, ADH7, FBP2, ENO2, PCK2, FBP1, GCK, ALDH3A1, ALDOC, ADH1C, ALDH2, ALDH1B1",0.165579296318467,0.100726812682396,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.61807,1.85,0.0237,2827,0.207,"B3GALT6, CHST14, CHSY1, XYLT2, B3GAT3, B4GALT7",1.6252516539899,0.684029654543082,TRUE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.3413,-1.07,0.318,8794,0.58,"HS6ST2",0.497572880015567,0.236572006437063,FALSE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.66224,1.99,0.0131,1356,0.149,"B4GALT1, ST3GAL2, B4GALT4",1.88272870434424,0.826813731587726,TRUE
+"H1650","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.53564,1.65,0.0482,1663,0.308,"GALNS, ARSB, GLB1, HPSE, NAGLU, HEXA",1.31695296176115,0.511449283499556,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.56792,1.73,0.0368,1663,0.272,"ST3GAL2, GLB1, HEXA",1.43415218132648,0.565431095965801,FALSE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.69372,2.12,0.00358,2389,0.0933,"ST3GAL2, HEXA, FUT1, NAGA",2.44611697335613,1.0301183562535,TRUE
+"H1650","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.56773,1.79,0.0267,1356,0.244,"B3GNT3, B4GALT1, ST3GAL4, FUT3, B4GALT4",1.57348873863542,0.612610173661271,TRUE
+"H1650","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.56312,1.73,0.0377,1311,0.272,"GPAA1, PIGT, PIGW, PIGS, PIGU, PIGK",1.42365864979421,0.565431095965801,FALSE
+"H1650","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.37042,1.15,0.266,2268,0.466,"MTHFD2, GRHPR, ACO2, MDH1",0.575118363368933,0.33161408331,FALSE
+"H1650","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.40632,1.23,0.191,2086,0.421,"CAMK2G, CAMK2B, PTK2B, PRKACB, ADCY6, PLD2, ADCY5, PRKCD, CAMK2D, MMP2, EGFR, ITPR2, GNAS, MAPK12, ADCY3, ADCY8, MAPK3, SOS1, MAPK14, PRKACA, PRKCA, GNAQ, MAPK13, SRC, CDC42, MAPK7, GNA11",0.718966632752272,0.375717904164332,FALSE
+"H1650","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.24094,-0.734,0.771,8187,0.904,"SHH, FBXW11",0.112945621949043,0.0438315695246367,FALSE
+"H1650","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.702,2.18,0.00373,853,0.0746,"ITGA4, ANPEP, ITGA6, ITGA3, CD36, CD9, ITGA1, CD14, ITGA2, MME, ITGA5, CD59, CD55, KITLG",2.42829116819131,1.12726117252733,TRUE
+"H1650","Input","KEGG_HISTIDINE_METABOLISM",-0.51952,-1.59,0.0778,8386,0.319,"ALDH3A1, ALDH2, HNMT, ALDH1B1, MAOA, DDC",1.10902040301031,0.496209316942819,FALSE
+"H1650","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.39924,-1.28,0.167,5027,0.457,"TOP3A, MRE11, SSBP1, POLD3, RPA3, POLD2, RPA2, RPA1, TOP3B, RAD51, MUS81, BLM",0.777283528852417,0.34008379993015,FALSE
+"H1650","Input","KEGG_HUNTINGTONS_DISEASE",0.13224,0.41,1,1932,1,"TGM2, NDUFA2, DNAH2, CYC1, UQCR10, SDHD, AP2A1, AP2B1, AP2S1, AP2M1, VDAC2, CREBBP, SDHC, EP300, CYCS, GNAQ, COX6A1, CASP8, UQCRC2, CLTC, UQCRFS1",0,0,FALSE
+"H1650","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.45307,1.4,0.123,731,0.343,"ITGA4, ITGA6, ITGA3, ITGB4, TPM2, ITGA1, ITGB1, ITGA2, ITGA5, SLC8A1, ITGB5, ACE, TPM1, DAG1",0.910094888560602,0.464705879957229,FALSE
+"H1650","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.25755,0.783,0.708,3028,0.84,"INPP4B, MINPP1, PLCD1, IMPA2, ITPK1, PI4KA, PIKFYVE, PIK3C2B, ISYNA1, INPP5K, PLCG2, INPP4A, PIK3C3, INPP1, INPPL1, PIP4K2C, PIK3CB, INPP5A, PIK3CA, PIK3CD, SYNJ1, PLCD3",0.149966742310231,0.0757207139381184,FALSE
+"H1650","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.25849,0.799,0.704,1790,0.836,"PRKACB, PRKCZ, PRKAR1B, PHKB, PHKA1, PPP1R3D, PRKAR1A, PRKCI, FASN, GYS1, PTPRF, PKLR, MAPK3, AKT2, AKT3, PIK3R3, PTPN1, SOS1, PRKAA1, PPP1R3A, EXOC7, TRIP10, MTOR, ACACA, PRKACA, INPP5K, HK1, CBLB",0.152427340857888,0.0777937225609836,FALSE
+"H1650","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.27213,0.816,0.692,1790,0.811,"IFNGR1, STAT1, STAT2, IRF9, STAT3, AKT2, AKT3, PIK3R3, SOS1, CREBBP, EP300, EPO, CBLB",0.159893905543242,0.090979145788844,FALSE
+"H1650","Input","KEGG_LEISHMANIA_INFECTION",0.49823,1.53,0.0774,1829,0.348,"ITGA4, TRAF6, IFNGR1, STAT1, ITGB2, ITGB1, C3, MYD88, MAPK12, MAPK3, MAP3K7, MAPK14, CR1, CYBA, MAPK13",1.11125903931711,0.458420756053419,FALSE
+"H1650","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.36077,1.12,0.276,1958,0.491,"ITGA4, CLDN6, ITGB2, CD99, ITGB1, CLDN4, ARHGAP35, PTK2B, F11R, CTNNA1, CTNNB1, OCLN, CTNND1, MMP2, CTNNA2, VAV2, PTK2, MAPK12, VASP, EZR, ACTN4, PIK3R3, PXN, MYL9, MAPK14, PRKCA, CXCR4, CYBA, ROCK1, RAP1A, MAPK13, MYL12A, ACTG1, MSN, CDC42",0.559090917934782,0.308918507877032,FALSE
+"H1650","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.4291,-1.31,0.169,8635,0.483,"ALDH2, ALDH1B1",0.772113295386326,0.316052869248488,FALSE
+"H1650","Input","KEGG_LONG_TERM_DEPRESSION",0.22147,0.69,0.889,2091,0.925,"GNAO1, ITPR2, GNAS, MAPK3, LYN, PRKCA, GNAQ, CACNA1A, GNA11, GNA12",0.0510982390297863,0.0338582672609674,FALSE
+"H1650","Input","KEGG_LONG_TERM_POTENTIATION",0.41177,1.26,0.184,1817,0.4,"CAMK2G, PPP3R2, CAMK2B, PPP3R1, PRKACB, PPP3CA, PPP3CB, CAMK2D, ITPR2, ADCY8, MAPK3, CREBBP, EP300, RPS6KA1, PRKACA, PRKCA, GNAQ, RAP1A",0.735182176990464,0.397940008672038,FALSE
+"H1650","Input","KEGG_LYSINE_DEGRADATION",-0.36126,-1.1,0.302,7926,0.588,"KMT5A, NSD2, SETMAR, KMT5C, PIPOX, SETDB2, NSD3, AASS, ALDH2, ALDH1B1",0.519993057042849,0.230622673923862,FALSE
+"H1650","Input","KEGG_LYSOSOME",0.48056,1.47,0.0766,1219,0.371,"GALC, AP1M2, CTSH, AP1S1, LIPA, GM2A, CTSL, CTSZ, AP1G1, CTSK, CTSO, GALNS, CTSV, ARSB, GGA2, LAMP3, PLA2G15, TCIRG1, GLB1, CTSA, ARSA, MANBA, AP1B1, NAPSA, CTSF, AP1S3",1.1157712303674,0.430626090384954,FALSE
+"H1650","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.33128,1.01,0.421,1661,0.599,"HSPA2, TRAF6, HSPA1L, HSPB1, CD14, PPP3R2, MAP3K5, TAOK3, PPP3R1, PRKACB, RRAS, PPP3CA, PPP3CB, TGFBR2, FLNC, MAP3K20, FGF13, FGF2, EGFR, MAPKAPK3, HSPA6, NFKB2, CDC25B, FAS, RASA1, MAPK12, MAPK8IP3, MAPK3, STK3, MAP3K7, ARRB1, AKT2, AKT3, SOS1, GNG12, HSPA1A, RPS6KA1, MAPK14, PRKACA, PRKCA",0.375717904164332,0.222573177610689,FALSE
+"H1650","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.48931,-1.54,0.0846,6087,0.345,"HNF1A, HNF4A, PDX1, HES1, GCK, FOXA2",1.07262963696098,0.462180904926726,FALSE
+"H1650","Input","KEGG_MELANOGENESIS",0.44204,1.34,0.142,1687,0.367,"CAMK2G, GNAO1, CAMK2B, FZD2, PRKACB, ADCY6, FZD1, CTNNB1, ADCY5, CAMK2D, KITLG, GNAS, ADCY3, ADCY8, MAPK3, CREBBP, EP300, PRKACA, PRKCA, GNAQ",0.847711655616944,0.435333935747911,FALSE
+"H1650","Input","KEGG_MELANOMA",0.23353,0.714,0.815,1392,0.915,"FGF13, FGF2, EGFR, MAPK3, AKT2, CDH1, AKT3, PIK3R3, HGF",0.0888423912600234,0.0385789059335517,FALSE
+"H1650","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.54792,-1.69,0.0562,7630,0.351,"ADH4, ADH7, GSTZ1, ALDH3A1, GSTM4, ADH1C, AKR1C2, AKR1C1, GSTM3, AKR1C3, GSTM2, GSTM1, GSTP1",1.25026368443094,0.454692883534176,FALSE
+"H1650","Input","KEGG_MISMATCH_REPAIR",-0.40526,-1.26,0.191,5305,0.444,"SSBP1, POLD3, RFC2, RFC3, RFC5, RPA3, POLD2, RPA2, RPA1, MSH2, RFC1, MSH6, RFC4",0.718966632752272,0.35261702988538,FALSE
+"H1650","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.30813,0.938,0.486,3004,0.664,"MAPK3, AKT2, AKT3, PIK3R3, PRKAA1, CAB39, RICTOR, RPS6KA1, MTOR, RPTOR, TSC2, AKT1, RPS6KA3, RHEB, PIK3CB, PIK3CA, RPS6KA6, PIK3CD, RPS6KA2, PDPK1",0.313363730737707,0.177831920631982,FALSE
+"H1650","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.4509,1.41,0.104,1393,0.348,"IFNGR1, ITGB2, RAET1L, ULBP2, PPP3R2, NFAT5, PTK2B, PPP3R1, PPP3CA, PPP3CB, VAV2, FAS, MAPK3, PIK3R3, SOS1",0.98296666070122,0.458420756053419,FALSE
+"H1650","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.34133,-1.07,0.349,7011,0.58,"PARD3, P2RY11, GRIN1, CHRM3, CGA, LTB4R2, F2",0.45717457304082,0.236572006437063,FALSE
+"H1650","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.21656,0.675,0.869,2954,0.921,"TRAF6, CAMK2G, CAMK2B, MAP3K5, ARHGDIB, PRKCD, CAMK2D, SH2B1, YWHAZ, GAB1, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SOS1, RPS6KA1, MAPK14, YWHAB, RAP1A, MAPK13, CDC42, MAPK7, PLCG2, NFKB1, RAC1, YWHAE, HRAS, MAPKAPK2, MAP3K3, AKT1, RPS6KA3, RIPK2, PIK3CB, RHOA, BCL2, RPS6KA4, IRS1, PIK3CA, RPS6KA6, MAGED1, PIK3CD, RPS6KA2",0.0609802235513335,0.0357403698031511,FALSE
+"H1650","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.44745,1.38,0.127,205,0.351,"NNMT, QPRT, BST1",0.896196279044043,0.454692883534176,FALSE
+"H1650","Input","KEGG_NITROGEN_METABOLISM",-0.4414,-1.38,0.115,7821,0.438,"GLUD2, CPS1, CA14, CA1, ASNS, CTH, CA8",0.939302159646388,0.3585258894959,FALSE
+"H1650","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37018,1.15,0.275,1987,0.466,"TRAF6, CASP1, IL18, NAIP, MAPK12, MAPK3, MAP3K7, MAPK14, CASP8, CASP5, MAPK13, CHUK, PYCARD",0.560667306169737,0.33161408331,FALSE
+"H1650","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.46852,-1.47,0.102,4762,0.374,"NHEJ1, MRE11, PRKDC, XRCC4, POLM, FEN1",0.991399828238082,0.42712839779952,FALSE
+"H1650","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.30704,-0.936,0.483,8588,0.673,"E2F3, RB1, FOXO3, FHIT, TP53",0.316052869248488,0.171984935776023,FALSE
+"H1650","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.22704,-0.713,0.848,7053,0.901,"HES1, SNW1, LFNG, KAT2A, CTBP1, DLL3, HDAC2, JAG1",0.0716041477432862,0.045275209020937,FALSE
+"H1650","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.42132,-1.27,0.195,5584,0.45,"RFC3, RFC5, RPA3, POLD2, XPC, RPA2, RPA1, CCNH, ERCC8, RFC1, CDK7, RFC4, POLE3, ERCC6, ERCC3, GTF2H5, CUL4A, GTF2H3, GTF2H4, GTF2H2, GTF2H1, MNAT1, ERCC5",0.709965388637482,0.346787486224656,FALSE
+"H1650","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.33445,1.03,0.379,2219,0.571,"B4GALT1, MAN2A2, MAN1B1, MAN2A1, TUSC3, STT3B, ALG2, MGAT1, DPM1, GANAB, MAN1A2, RFT1, DDOST",0.421360790031928,0.243363891754152,FALSE
+"H1650","Input","KEGG_OLFACTORY_TRANSDUCTION",0.36076,1.11,0.31,668,0.493,"CAMK2G, CAMK2B, PRKACB, CAMK2D",0.508638306165727,0.30715308072277,FALSE
+"H1650","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.22552,-0.709,0.827,5223,0.89,"TYMS, ATIC, MTHFD1L, MTR, MTFMT, SHMT2",0.0824944904474534,0.0506099933550872,FALSE
+"H1650","Input","KEGG_OOCYTE_MEIOSIS",0.41873,1.29,0.161,1812,0.391,"CAMK2G, PPP3R2, CAMK2B, PPP3R1, PRKACB, ADCY6, PPP3CA, PPP3CB, ADCY5, CAMK2D, AR, ITPR2, PPP2R5E, YWHAZ, MAPK12, ADCY3, ADCY8, PLK1, MAPK3, SKP1, RPS6KA1, PRKACA, PPP2R5A, CDK1, YWHAB",0.79317412396815,0.407823242604133,FALSE
+"H1650","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.35693,1.1,0.302,1663,0.502,"GLB1, MANBA, MAN2B2, HEXA",0.519993057042849,0.299296282854981,FALSE
+"H1650","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.13403,0.408,1,2760,1,"NDUFA2, CYC1, UQCR10, LHPP, TCIRG1, SDHD, COX15, SDHC, COX6A1, ATP12A, ATP6V1C2, UQCRC2, UQCRFS1, SDHB, ATP6V1C1, UQCRC1, NDUFA3, UQCRQ, SDHA, COX17, COX6B1, COX7A2, COX7A2L, COX4I1, NDUFA4, UQCRH",0,0,FALSE
+"H1650","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.81624,2.49,0,683,0.0158,"GALNT6, C1GALT1, C1GALT1C1, GALNT14, GALNT15, GALNT10, GALNT13, GALNT7, GALNT3, GALNT12, GALNT2, ST3GAL2, B4GALT5",Inf,1.80134291304558,TRUE
+"H1650","Input","KEGG_P53_SIGNALING_PATHWAY",0.44078,1.38,0.11,1793,0.351,"TP53I3, SERPINB5, CD82, EI24, RRM2, DDB2, FAS, RRM2B, SFN, IGFBP3, CYCS, CHEK2, CASP8, CDK1",0.958607314841775,0.454692883534176,FALSE
+"H1650","Input","KEGG_PANCREATIC_CANCER",0.2311,0.702,0.842,2235,0.925,"STAT1, ERBB2, TGFBR2, EGFR, SMAD3, RALA, STAT3, MAPK3, AKT2, AKT3, PIK3R3, RALB, CDC42, JAK1, CHUK, SMAD2, NFKB1, RAC1",0.0746879085003505,0.0338582672609674,FALSE
+"H1650","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.3653,1.11,0.278,1470,0.493,"PPCS, BCAT2, PANK4",0.555955204081924,0.30715308072277,FALSE
+"H1650","Input","KEGG_PARKINSONS_DISEASE",0.19018,0.582,0.965,837,0.984,"UBE2L6, UBA7, NDUFA2, CYC1, UQCR10, SDHD",0.0154726866562074,0.00700490156865849,FALSE
+"H1650","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.31159,0.944,0.475,1958,0.667,"ITGB1, CD14, CTNNB1, OCLN, TUBA4A, YWHAZ, CDH1, EZR, ARPC1B, PRKCA, ROCK1, ACTG1, CDC42",0.323306390375133,0.175874166083451,FALSE
+"H1650","Input","KEGG_PATHWAYS_IN_CANCER",0.27649,0.857,0.619,1661,0.749,"TRAF6, ITGA6, STAT1, ITGA3, ITGB1, ERBB2, LAMA5, ITGA2, FZD2, RXRA, FZD1, CTNNA1, CTNNB1, SLC2A1, TGFBR2, MMP2, LAMA3, LAMA4, CTNNA2, APC, FGF13, FGF2, KITLG, AR, PTK2, EGFR, NFKB2, ITGAV, FAS, LAMB1, SMAD3, RARA, RALA, STAT3, MAPK3, AKT2, CDH1, AKT3, PIK3R3, HGF, SOS1, DAPK1, CKS1B, CREBBP, FLT3, EP300, MTOR, CYCS, PRKCA",0.208309350979882,0.125518182300534,FALSE
+"H1650","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.42783,-1.3,0.169,8393,0.449,"UGDH, CRYL1",0.772113295386326,0.347753658996677,FALSE
+"H1650","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.27629,0.839,0.642,998,0.775,"PGM1, RBKS, H6PD, PFKP",0.192464971931147,0.11069829749369,FALSE
+"H1650","Input","KEGG_PEROXISOME",0.48695,1.5,0.0926,2573,0.344,"PXMP4, ACOX3, SLC25A17, DECR2, MVK, ECH1, ACSL1, ACSL5, ACOT8, ACAA1, ABCD1, CROT, DAO, AMACR, ACOX1, GSTK1, HACL1, ACSL6, PEX13, HSD17B4, ABCD3, CAT, CRAT, PXMP2, PEX3, PEX14, PEX11A, AGPS, SCP2, ECI2, IDH1, PRDX1, EHHADH, ACSL3, PRDX5, NUDT19, PEX26, IDH2",1.03338901331807,0.46344155742847,FALSE
+"H1650","Input","KEGG_PHENYLALANINE_METABOLISM",-0.59458,-1.86,0.0211,8386,0.632,"ALDH3A1, MAOA, DDC",1.67571754470231,0.199282921717615,FALSE
+"H1650","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25482,0.776,0.712,1672,0.837,"INPP4B, DGKA, PLCD1, IMPA2, ITPR2, ITPK1, PI4KA, PIKFYVE, PIK3R3, PIK3C2B, DGKB, CDS1, PRKCA, INPP5K",0.147520006363144,0.07727454200674,FALSE
+"H1650","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.53052,1.63,0.055,1730,0.314,"CP, EARS2, FTH1, BLVRB, COX15, HCCS, HMOX1, UROS, FECH",1.25963731050576,0.503070351926785,FALSE
+"H1650","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.39589,1.21,0.21,1093,0.435,"SCD5, CD36, SLC27A6, ACOX3, FADS2, SCD, RXRA, ACSL1, ACSL5, SLC27A4, ACAA1, ACOX1, ACSL6",0.677780705266081,0.361510743045363,FALSE
+"H1650","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.41756,1.27,0.15,1109,0.394,"CYP7B1, AMACR, HSD17B4",0.823908740944319,0.404503778174426,FALSE
+"H1650","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.52972,1.62,0.0496,1156,0.309,"CD40, TAP1, TAP2, ADA",1.3045183235098,0.510041520575165,FALSE
+"H1650","Input","KEGG_PRION_DISEASES",-0.32333,-0.994,0.373,8618,0.657,"C9, NCAM1",0.428291168191312,0.182434630440219,FALSE
+"H1650","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.40222,1.2,0.221,1829,0.435,"PRKACB, ADCY6, ADCY5, CDC25B, MAPK12, ADCY3, ADCY8, PLK1, MAPK3, AKT2, FZR1, AKT3, PIK3R3, RPS6KA1, MAPK14, PRKACA, CDK1, MAPK13",0.655607726314889,0.361510743045363,FALSE
+"H1650","Input","KEGG_PROPANOATE_METABOLISM",-0.28258,-0.865,0.577,8180,0.751,"ACSS3, PCCB, ALDH6A1, PCCA, ALDH2, ALDH1B1",0.238824186844269,0.124360062995832,FALSE
+"H1650","Input","KEGG_PROSTATE_CANCER",-0.31824,-0.979,0.438,8368,0.666,"IKBKB, E2F3, RB1, TP53, GSTP1, CDKN1B",0.3585258894959,0.176525770829699,FALSE
+"H1650","Input","KEGG_PROTEASOME",0.31048,0.958,0.464,263,0.656,"PSMB10, PSMB9",0.333482019445119,0.18309616062434,FALSE
+"H1650","Input","KEGG_PROTEIN_EXPORT",-0.16757,-0.51,0.994,1481,0.991,"SEC62, SRP19, SRP54, SRPRA, SRP68, SRP72, SPCS1, HSPA5, SPCS3, SRPRB, SPCS2, SEC11A, OXA1L, IMMP1L, SEC61B, SRP14, SEC61A1, SRP9, SEC63, SEC11C",0.00261361560268669,0.00392634551472468,FALSE
+"H1650","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.43619,1.32,0.157,2268,0.361,"GLS, GLS2, ATP1B3, ATP1B1, ATP1A3, ATP1A1, ATP1A4, CA2, MDH1",0.804100347590766,0.442492798094342,FALSE
+"H1650","Input","KEGG_PURINE_METABOLISM",-0.22859,-0.72,0.812,5972,0.909,"APRT, POLR3F, GMPS, POLR1B, POLR1A, POLR2I, PRPS1, PRPS1L1, POLR3H, POLR3G, POLR2D, POLR1E, NME2, PDE6D, GUK1, POLR3C, ITPA, PRIM1, POLR2C, POLR2H, NUDT2, POLA1, POLR2L, PNP, PFAS, AK2, POLR2E, NME7, POLE3, AK1, NT5C, PRIM2, NUDT5, NME1, AK5, POLA2, GMPR2, PDE3A, PDE4A, PDE1C, POLR1C, POLR1D, GMPR, XDH, IMPDH1, NPR2, FHIT",0.0904439707588247,0.0414361167780325,FALSE
+"H1650","Input","KEGG_PYRIMIDINE_METABOLISM",0.19702,0.615,0.944,1078,0.976,"CDA, CMPK2, NME3, TYMP, RRM2, NME4, TK1, TK2, DHODH, RRM2B",0.025028005701931,0.0105501823333082,FALSE
+"H1650","Input","KEGG_PYRUVATE_METABOLISM",0.23467,0.731,0.816,2433,0.897,"ALDH7A1, ACSS2, AKR1B1, ME3, PKLR, ALDH3A2, PC, ACACA, GRHPR, ACAT2, ACSS1, ACACB, MDH1, DLD, ME2",0.0883098412461389,0.0472075569559079,FALSE
+"H1650","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.40176,1.23,0.2,1645,0.421,"ITGA4, ITGA6, ITGA3, ITGB4, ITGB2, ITGA1, ITGB1, CD14, MYH14, ARHGAP35, ITGA2, ITGA5, RDX, RRAS, TIAM1, ITGB5, FGD3, APC, FGF13, FGF2, VAV2, PTK2, EGFR, SLC9A1, ITGAV, LIMK2, CFL2, MYH9, ITGB8, TIAM2, MAPK3, GSN, PIKFYVE, BAIAP2, EZR, ACTN4, PIK3R3, SOS1, PXN, GNG12, MYL9, ARPC1B, CYFIP2, NCKAP1",0.698970004336019,0.375717904164332,FALSE
+"H1650","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.28536,0.888,0.6,2369,0.715,"GABARAPL2, GABARAPL1, PRKAA1, PIK3R4, ATG4B, ATG4A, PIK3C3",0.221848749616356,0.145693958198919,FALSE
+"H1650","Input","KEGG_RENAL_CELL_CARCINOMA",0.22774,0.688,0.824,3477,0.92,"SLC2A1, GAB1, MAPK3, AKT2, AKT3, PIK3R3, HGF, SOS1, CREBBP, EP300, RAP1A, CDC42, RAC1, HRAS, PAK5, PAK6, AKT1, CUL2, PAK4, PIK3CB, PIK3CA, PIK3CD, ELOB, CRKL, PIK3R2, RBX1, MAPK1, MAP2K1, FLCN, PAK2, KRAS, NRAS",0.0840727883028842,0.0362121726544447,FALSE
+"H1650","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.6738,2.06,0.00538,843,0.117,"CPA3, ANPEP, MME, ACE, CTSA",2.26921772433361,0.931814138253838,TRUE
+"H1650","Input","KEGG_RETINOL_METABOLISM",-0.33223,-1.04,0.367,7630,0.614,"ADH4, ADH7, ADH1C, ALDH1A1, ALDH1A2",0.435333935747911,0.211831628858832,FALSE
+"H1650","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.32563,-1.02,0.391,5705,0.63,"ACP1, FLAD1, TYR, MTMR6, ACP5, RFK",0.407823242604133,0.200659450546418,FALSE
+"H1650","Input","KEGG_RIBOSOME",-0.37685,-1.16,0.242,4360,0.531,"RPS2, RPS19, RPL3, RPL23, RPL21, RPS17, RPL7A, RPL9, RPS9, RPSA, RPL17, MRPL13, RPL13, RPL6, RPS13, RPLP2, RPS5, RPS7, RPL31, RPL4, RPL32, RPL19, RPL22, RPL27A, RPS29, RPS27A, RPL29, RPLP1, RPS25, RPS28, UBA52, RPS27L, RPS20, FAU, RPS11, RPS12, RPS10, RPL24, RSL24D1, RPL36A, RPL36AL, RPS21, RPS6, RPS23, RPL38, RPL37, RPL22L1",0.616184634019569,0.274905478918531,FALSE
+"H1650","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.46886,1.46,0.103,2213,0.327,"TRAF6, DDX58, ISG15, PIN1, IRF3, TRADD, CYLD, MAPK12, TRIM25, MAP3K7, MAPK14, CASP8, TKFC, MAPK13, CASP10, CHUK, TBK1, NFKB1",0.987162775294828,0.485452247339714,FALSE
+"H1650","Input","KEGG_RNA_DEGRADATION",-0.28274,-0.862,0.567,5355,0.722,"EXOSC6, XRN2, DCP2, EXOSC9, EXOSC10, EXOSC5, LSM6, DIS3, LSM8, EDC3, EXOSC8, EXOSC1, MPHOSPH6, EXOSC4, LSM1, PAPOLG, HSPD1, LSM2, DDX6, CNOT2, LSM7, ENO2, LSM4, DCP1B",0.246416941107093,0.141462802430361,FALSE
+"H1650","Input","KEGG_RNA_POLYMERASE",-0.53795,-1.68,0.0591,5344,0.282,"POLR3D, POLR2G, POLR3K, POLR3GL, POLR2J, POLR3F, POLR1B, POLR1A, POLR2I, POLR3H, POLR3G, POLR2D, POLR1E, POLR3C, POLR2C, POLR2H, POLR2L, POLR2E, POLR1C, POLR1D",1.22841251911874,0.549750891680639,FALSE
+"H1650","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.36514,1.09,0.321,123,0.512,"GGT1, PAPSS2",0.493494967595128,0.290730039024169,FALSE
+"H1650","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.29059,-0.912,0.519,8190,0.7,"FN1, LAMA1, IKBKB, E2F3, RB1, PTGS2, FHIT, TP53, MYC, ITGA2B, CDKN1B",0.284832642151542,0.154901959985743,FALSE
+"H1650","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.28169,0.86,0.608,2752,0.751,"VAMP8, BET1L, YKT6, STX16, VAMP3, STX4, GOSR1, STX8, VAMP2, SNAP47, VAMP4, STX10",0.216096420727265,0.124360062995832,FALSE
+"H1650","Input","KEGG_SPHINGOLIPID_METABOLISM",0.54486,1.66,0.0532,1396,0.336,"PLPP3, GALC, SPTLC2, GLB1, ARSA, DEGS1, SPTLC1, PLPP1, SPHK2",1.27408836770495,0.473660722610156,FALSE
+"H1650","Input","KEGG_SPLICEOSOME",-0.39623,-1.22,0.194,5458,0.48,"DHX15, PRPF31, SRSF10, ALYREF, EFTUD2, SRSF5, PRPF4, PHF5A, HNRNPK, SF3B6, EIF4A3, U2AF2, TRA2A, LSM6, RBMX, NCBP1, PLRG1, SRSF4, SF3B4, SMNDC1, HSPA8, U2SURP, CDC5L, LSM8, SNRPG, MAGOHB, DHX16, RBM25, SF3A1, PPIH, U2AF1, CHERP, PRPF19, ISY1, RBM22, SF3A2, SF3B3, PRPF18, SF3B2, RBM8A, SYF2, ZMAT2, HNRNPC, SNRPC, BCAS2, CRNKL1, NCBP2, PRPF40A, SRSF1, TCERG1, PPIE, TRA2B, PPIL1, SNW1, SRSF3, CDC40, BUD31, LSM2, SLU7, TXNL4A, LSM7, SNRNP40, DDX5, RBM17, SRSF2, SNRNP27, HNRNPM, SRSF8, HNRNPU, SART1, WBP11, PQBP1, HNRNPA3, CCDC12, ACIN1, HNRNPA1, CWC15, LSM4, SNU13",0.712198270069774,0.318758762624413,FALSE
+"H1650","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.31163,0.957,0.448,1077,0.651,"PGM1, SI, UGP2, GYS1",0.348721986001856,0.186419011431808,FALSE
+"H1650","Input","KEGG_STEROID_BIOSYNTHESIS",0.47462,1.5,0.0598,759,0.344,"CEL, LIPA, DHCR24, SQLE, MSMO1",1.22329881601159,0.46344155742847,FALSE
+"H1650","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.55675,-1.76,0.037,8521,0.314,"HSD11B2, AKR1D1, AKR1C2, AKR1C1, AKR1C3, HSD17B8",1.431798275933,0.503070351926785,FALSE
+"H1650","Input","KEGG_SULFUR_METABOLISM",0.89874,2.82,0,196,0.00126,"SULT1A3, SULT2B1, PAPSS2, SULT1A1",Inf,2.89962945488244,TRUE
+"H1650","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.47555,1.46,0.0859,1378,0.327,"CD40, C3, TRIM21, ACTN4",1.06600683616876,0.485452247339714,FALSE
+"H1650","Input","KEGG_TASTE_TRANSDUCTION",0.70438,2.24,0.00186,2081,0.0775,"PRKACB, ADCY6, GNAS, ADCY8, PRKACA, CACNA1A",2.73048705578208,1.11069829749369,TRUE
+"H1650","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.34493,1.05,0.362,2017,0.551,"MVK, MVD, HMGCR, ACAT2, HMGCS1",0.441291429466834,0.258848401148215,FALSE
+"H1650","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.21329,-0.654,0.889,6297,0.931,"SP1, INHBE, AMH, RPS6KB2, SMURF2, ACVR1, CHRD, TGFB2, TGFB3, TGFBR1, TFDP1, SMAD5, MYC",0.0510982390297863,0.0310503190186574,FALSE
+"H1650","Input","KEGG_THYROID_CANCER",-0.319,-0.95,0.484,8756,0.682,"TP53, MYC",0.315154638355588,0.166215625343521,FALSE
+"H1650","Input","KEGG_TIGHT_JUNCTION",0.41238,1.27,0.179,1993,0.394,"CLDN6, EPB41L1, MYH14, MYH7B, CLDN4, MYH4, PRKCQ, RRAS, F11R, CTNNA1, CTNNB1, OCLN, PRKCD, PRKCZ, MAP3K20, CTNNA2, TJP3, PRKCI, PARD6B, LLGL2, PARD6G, MYH11, CGN, MYH9, CASK, AKT2, VAPA, ACTN4, AKT3, MYH3, PRKCE, TJP2, MAGI3, EXOC3, MYL9, PRKCA, AMOTL1, MYL12A, ACTG1, SRC, CDC42, EXOC4",0.747146969020107,0.404503778174426,FALSE
+"H1650","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45925,1.41,0.11,2235,0.348,"CD40, TRAF6, STAT1, CD14, CTSK, IRF3, MYD88, TICAM2, MAPK12, TLR9, MAPK3, MAP3K7, AKT2, AKT3, PIK3R3, MAPK14, CASP8, MAPK13, CHUK, TBK1, NFKB1, RAC1",0.958607314841775,0.458420756053419,FALSE
+"H1650","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.34755,-1.1,0.282,8197,0.588,"HAAO, WARS2, ALDH2, ALDH1B1, MAOA, DDC",0.549750891680639,0.230622673923862,FALSE
+"H1650","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.29609,0.911,0.516,1750,0.693,"PRKCD, PRKCZ, ABCC8, PKLR, MAPK3, PIK3R3, PRKCE, MTOR, HK1",0.287350298372789,0.159266765388193,FALSE
+"H1650","Input","KEGG_TYROSINE_METABOLISM",-0.61024,-1.88,0.0234,7263,1,"BUD23, METTL2B, ADH4, ADH7, TYRP1, GSTZ1, FAH, ALDH3A1, DCT, ADH1C, MAOA, DDC",1.63078414258986,0,FALSE
+"H1650","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.3151,0.967,0.464,2728,0.647,"PPP3R2, NFAT5, PRKCQ, MALT1, PPP3R1, PPP3CA, PPP3CB, VAV2, MAPK12, MAPK3, MAP3K7, AKT2, AKT3, PIK3R3, SOS1, MAPK14, CBLB, MAPK13, CDC42, CHUK, NFKB1, FYN, HRAS, PAK5, PAK6, AKT1, CHP1, PAK4, PIK3CB, BCL10, RHOA, PTPN6",0.333482019445119,0.1890957193313,FALSE
+"H1650","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.30281,0.925,0.501,1790,0.682,"UBE2L6, TRAF6, UBA7, FBXO2, KEAP1, WWP2, FBXO4, UBE3B, DDB2, HERC4, ITCH, WWP1, HUWE1, FZR1, SYVN1, NEDD4, MID1, SKP1, TRIM32, SKP2, CBLB",0.300162274132754,0.166215625343521,FALSE
+"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.33149,1.04,0.357,5924,0.561,"BCAT2, IARS2, LARS2, BCAT1, PDHB, PDHA1, VARS2",0.447331783887807,0.251037138743839,FALSE
+"H1650","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.30165,0.918,0.543,2929,0.688,"ABAT, ALDH7A1, ACAA1, HIBADH, ALDH3A2, BCAT2, OXCT1, ACAT2, HMGCS1, AUH, ACAD8, DLD, EHHADH, BCKDHB, MCCC2, HADH, HADHA, HADHB, ALDH9A1, ACADSB, MCCC1, MCEE",0.265200170411153,0.162411561764489,FALSE
+"H1650","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.34902,1.06,0.359,1760,0.54,"KCNMA1, PRKCQ, PRKACB, ADCY6, ADCY5, PRKCD, ITPR2, GNAS, MYL6, MYH11, ADCY3, ADCY8, MAPK3, PRKCE, MYL9, PRKACA, PRKCA, PPP1R12B, GNAQ, ROCK1",0.444905551421681,0.267606240177031,FALSE
+"H1650","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.50687,1.59,0.0444,2693,0.33,"PRKACB, ARHGDIB, ADCY6, RAB11A, GNAS, DYNC1LI2, ADCY3, RAB11B, DYNC1I2, DYNC1H1, PRKACA, STX4, RAB5B, RAB5C, DYNC2H1, DCTN1, RAB5A, VAMP2, DCTN4, DCTN6, DYNLL2",1.35261702988538,0.481486060122112,FALSE
+"H1650","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.44319,1.37,0.125,2710,0.354,"HSPB1, PPP3R2, NFAT5, PPP3R1, PPP3CA, PPP3CB, PTK2, MAPKAPK3, MAPK12, MAPK3, AKT2, AKT3, PIK3R3, SPHK2, PXN, MAPK14, PRKCA, MAPK13, SRC, CDC42, SH2D2A, PLCG2, RAC1, HRAS, MAPKAPK2, AKT1, PLA2G12A, CHP1, PIK3CB",0.903089986991944,0.450996737974212,FALSE
+"H1650","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.25989,0.798,0.709,2193,0.829,"PRKACB, ERO1A, KDELR3, TCIRG1, GNAS, ADCY3, TJP2, PRKACA, PRKCA, ATP6V1C2, ACTG1, PLCG2, ATP6V1C1",0.149353764816933,0.0814454694497265,FALSE
+"H1650","Input","KEGG_VIRAL_MYOCARDITIS",0.46071,1.4,0.116,1185,0.343,"CD40, ITGB2, CAV1, MYH14, MYH7B, MYH4, CD55, DAG1, CXADR, MYH11, MYH9",0.935542010773082,0.464705879957229,FALSE
+"H1650","Input","KEGG_WNT_SIGNALING_PATHWAY",0.28828,0.893,0.574,1803,0.713,"CAMK2G, PPP3R2, CAMK2B, NFAT5, FZD2, PPP3R1, PRKACB, FZD1, PPP3CA, CTNNB1, PPP3CB, CAMK2D, APC, PPP2R5E, SMAD3, MAP3K7, PORCN, CREBBP, SKP1, EP300, PRKACA, PRKCA, PPP2R5A, ROCK1, VANGL1",0.241088107602027,0.146910470148134,FALSE
+"H1975","Input","KEGG_ABC_TRANSPORTERS",0.3515,1.06,0.354,1220,0.606,"ABCG2, ABCA3, TAP1, ABCB8, ABCA1",0.450996737974212,0.217527375833714,FALSE
+"H1975","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.36108,1.1,0.307,2283,0.617,"MYC, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, STAT5A, RPS6KB2, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, RUNX1, TCF7L1, NFKB1, BRAF",0.512861624522813,0.209714835966758,FALSE
+"H1975","Input","KEGG_ADHERENS_JUNCTION",0.18147,0.552,0.983,2134,1,"RAC2, SORBS1, WASF1, ACTN3, FER, VCL, ACTN1, MAP3K7, FYN, MAPK1, SMAD4, TGFBR1, TCF7L1",0.00744648216786438,0,FALSE
+"H1975","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.31622,-0.959,0.449,8785,0.678,"PCK2, RXRB, PRKAB1, ACSL6, CPT1A, SLC2A1, ADIPOR2, ADIPOR1, PRKAA2",0.347753658996677,0.168770306132937,FALSE
+"H1975","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39596,1.17,0.252,1268,0.583,"GFPT2, ADSL, ASL, ASNS, ASS1, CPS1",0.598599459218456,0.234331445240986,FALSE
+"H1975","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.25709,0.774,0.747,2963,0.836,"PRKCA, PRKCB, PIK3R2, NR3C2, PIK3CA, MAPK1, IRS1, PDPK1, IRS2, SFN, NEDD4L, INSR",0.126679398184601,0.0777937225609836,FALSE
+"H1975","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.62443,-1.95,0.0135,8351,0.24,"PLA2G12A, ACOX3, PLA2G2D, ACOX1, PLA2G4A, PLA2G2A",1.86966623150499,0.619788758288394,TRUE
+"H1975","Input","KEGG_ALZHEIMERS_DISEASE",-0.22158,-0.686,0.876,7249,0.908,"APOE, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, ADAM10, COX5B, BID, ATP5F1D, UQCRFS1, BAD, UQCRC2, COX5A, ATP5PF, NCSTN, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, PLCB2, APP, CYC1, ATP5PD, ATP2A2, UQCRB, CASP7, PLCB4, SNCA, BACE2, MME, PLCB1",0.0574958938319193,0.0419141514789149,FALSE
+"H1975","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.20376,0.619,0.928,7903,0.985,"LARS2, FARS2, HARS2, FARSB, FARSA, SEPSECS, CARS2, RARS2, TARS2, DARS2, MTFMT, YARS2, NARS2, VARS2, MARS2, PARS2, IARS2, EARS2, SARS2, WARS2, AARS2",0.0324520237811379,0.00656376950238827,FALSE
+"H1975","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.42705,1.31,0.149,2528,0.629,"GFPT2, RENBP, UAP1, AMDHD2, GMPPA, UGDH, GMPPB, HK2, GNPDA1, GPI, NAGK, GNE, PGM2, CYB5R3, HK3, PGM3",0.826813731587726,0.201349354554731,FALSE
+"H1975","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.48166,1.45,0.0884,505,0.698,"NEFH, PRPH, PRPH2, TP53, NEFM, CCS",1.05354773498693,0.156144577376839,FALSE
+"H1975","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.15472,0.47,0.998,2208,0.997,"CD74, TAP1, LGMN, CTSB, CTSL, HSPA2",0.000869458712628891,0.00130484168834428,FALSE
+"H1975","Input","KEGG_APOPTOSIS",0.47654,1.46,0.0996,2233,0.828,"TP53, IL1RAP, PRKACA, PRKAR1B, AKT1, CASP8, ENDOG, TRADD, PIK3R2, IRAK4, IRAK1, MYD88, TNFRSF10D, CAPN2, PIK3CA, IKBKG, PPP3CA, XIAP, CHUK, IKBKB, PRKAR1A, PPP3CB, IRAK2, PRKACB, PRKAR2A, FADD, ENDOD1, NFKB1",1.0017406615763,0.0819696632151199,FALSE
+"H1975","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.40931,-1.27,0.191,8863,0.438,"PLA2G2D, TBXAS1, ALOX5, CYP2J2, CYP4F3, AKR1C3, PLA2G4A, PTGS2, PLA2G2A",0.718966632752272,0.3585258894959,FALSE
+"H1975","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.34722,1.05,0.387,1902,0.59,"NOS3, MAOB, ASL, ARG1, ASS1, GATM, CPS1, CKB, MAOA, SMS, OAT, GLS, GLS2",0.412289034981089,0.229147988357856,FALSE
+"H1975","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.32182,-1,0.428,9580,0.669,"ITGA1, CACNA2D1, ITGB8, PKP2, CDH2, SGCD",0.368556230986828,0.174573882232177,FALSE
+"H1975","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.32282,-0.978,0.458,7529,0.677,"ALDH7A1, ALDH3A2, ALDH2",0.339134521996131,0.169411331314856,FALSE
+"H1975","Input","KEGG_AXON_GUIDANCE",0.42478,1.28,0.161,1781,0.613,"RAC2, ABLIM3, SEMA3B, PAK5, PAK6, SRGAP1, DPYSL2, LIMK1, RGS3, EPHB2, SEMA7A, RASA1, PLXNA3, GNAI2, EPHB4, ABLIM1, NRP1, ROBO1, SRGAP2, SRGAP3, SEMA4C, PAK1, FYN, PPP3CA, MAPK1",0.79317412396815,0.212539525481585,FALSE
+"H1975","Input","KEGG_BASAL_CELL_CARCINOMA",0.41379,1.23,0.208,919,0.571,"FZD2, TP53, WNT5B, DVL1, DVL2",0.681936665037238,0.243363891754152,FALSE
+"H1975","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.18977,0.572,0.972,8043,1,"STON1, TAF11, GTF2E2, GTF2IRD1, GTF2E1, TAF1, TAF7, GTF2F1, TAF4, GTF2H3, GTF2A2, GTF2H4, TAF6L, GTF2H2, TAF2, TAF6, TBPL1, GTF2F2, TBP, TAF5, TAF5L, GTF2A1, TAF9, TAF9B, TAF10, GTF2B, GTF2I, TAF12, GTF2H1",0.0123337350737254,0,FALSE
+"H1975","Input","KEGG_BASE_EXCISION_REPAIR",-0.43785,-1.36,0.135,6637,0.434,"POLB, PCNA, PARP1, PARP2, MBD4, POLE3, MPG, XRCC1, LIG1, UNG, TDG, FEN1, POLD1, HMGB1, POLD3, MUTYH, POLE, POLD2, APEX2, POLE2",0.869666231504994,0.362510270487489,FALSE
+"H1975","Input","KEGG_BETA_ALANINE_METABOLISM",-0.2739,-0.827,0.657,7467,0.822,"ACADM, ALDH7A1, HADHA, ABAT, ALDH3A2, HIBCH, ALDH2",0.182434630440219,0.0851281824599496,FALSE
+"H1975","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.24323,0.738,0.792,1537,0.881,"ACOT4, HACD2, HACD1, ACAA1",0.101274818410506,0.0550240915879521,FALSE
+"H1975","Input","KEGG_BLADDER_CANCER",0.33074,1.01,0.386,2283,0.598,"TP53, MYC, THBS1, ARAF, TYMP, MAP2K2, RAF1, CDKN1A, MAPK1, VEGFA, DAPK3, CDK4, BRAF",0.413412695328245,0.223298816011589,FALSE
+"H1975","Input","KEGG_BUTANOATE_METABOLISM",-0.49108,-1.54,0.0706,7529,0.348,"ALDH7A1, HADH, HADHA, ACADS, OXCT1, ABAT, ALDH3A2, HMGCS1, L2HGDH, ACAT2, ALDH2, BDH1, ALDH5A1",1.1511952989482,0.458420756053419,FALSE
+"H1975","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.37051,1.11,0.276,1904,0.609,"RAC2, CD79A, CARD11, CD81, VAV2, VAV1, AKT1, MALT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, PIK3CA, IKBKG, LYN, PPP3CA, MAPK1, CHUK, IKBKB, PPP3CB",0.559090917934782,0.215382707367125,FALSE
+"H1975","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.40289,1.2,0.221,2506,0.575,"NOS3, TNNC1, MYLK, PRKACA, PRKCA, CACNA1A, F2R, ITPR1, GNA15, ADCY7, PHKA1, PRKCB, PLCG2, GNA11, PHKB, CACNA1F, PTK2B, ATP2B1, PPP3CA, PPP3CB, ATP2A3, PRKACB, PHKG2, ITPR3, ATP2B2, ATP2B4, PLCD1, PHKA2, GNAS, CAMK2G, GRIN1",0.655607726314889,0.24033215531037,FALSE
+"H1975","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.31443,0.932,0.497,257,0.629,"MYH7, TNNC1, TPM4",0.303643611266668,0.201349354554731,FALSE
+"H1975","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.327,0.984,0.417,1763,0.615,"VCAN, ICAM2, CD274, SDC4, ICAM1, CD40, CNTNAP1, CLDN4, CADM1, MPZ, CDH15, CDH3, PVR, CLDN16, CLDN6, SPN, CD276, CLDN3, SDC1, ALCAM",0.379863945026242,0.211124884224583,FALSE
+"H1975","Input","KEGG_CELL_CYCLE",-0.37917,-1.15,0.278,7661,0.51,"ATR, ORC4, ANAPC7, ORC1, CDC25C, ORC2, CDC25B, CDC45, MCM2, MCM7, CDC26, RB1, RAD21, MCM4, MCM6, MCM3, ESPL1, DBF4, STAG1, TFDP2, PLK1, ORC3, ZBTB17, CDC7, E2F3, MAD2L1, TFDP1, MDM2, BUB1B, MAD2L2, CHEK1, TTK, BUB1, PTTG1, ORC6, TGFB1, CCNB2, WEE1, CDC20, SKP2, CCNA2, CDC14B",0.555955204081924,0.292429823902064,FALSE
+"H1975","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.28638,0.86,0.611,2283,0.702,"RAC2, PRKACA, GNG10, VAV2, VAV1, AKT1, ADCY7, PRKCB, RAF1, PIK3R2, GNAI2, BCAR1, PRKCD, GNB4, PTK2B, GRK2, PIK3CA, IKBKG, PAK1, STAT2, LYN, GNG5, HCK, MAPK1, CHUK, IKBKB, FOXO3, PRKACB, ARRB1, NFKB1, CRK, BRAF",0.213958789757446,0.153662887870195,FALSE
+"H1975","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.35431,1.09,0.315,2845,0.616,"TP53, MYC, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, CDKN1B, STAT5A, BCR, CDKN1A, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, SMAD4, TGFBR1, CDK4, RUNX1, NFKB1, CRK, BRAF, CRKL, TGFB2, CBL, SOS2, CCND1",0.501689446210399,0.210419287835575,FALSE
+"H1975","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.26691,-0.814,0.676,6745,0.814,"CLOCK, CSNK1E, BHLHE40",0.170053304058364,0.0893755951107988,FALSE
+"H1975","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.34781,-1.09,0.327,6653,0.543,"MDH2, OGDH, OGDHL, IDH3G, SDHB, DLST, IDH3B, IDH3A, PCK2, DLAT, IDH2",0.485452247339714,0.265200170411153,FALSE
+"H1975","Input","KEGG_COLORECTAL_CANCER",0.32619,0.981,0.423,2283,0.606,"RAC2, TP53, MYC, AKT1, ARAF, RAF1, PIK3R2, MAPK10, MAPK8, PIK3CA, APPL1, MAPK1, APC, SMAD4, TGFBR1, TCF7L1, BRAF",0.373659632624958,0.217527375833714,FALSE
+"H1975","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.38026,1.13,0.305,868,0.601,"SERPINE1, PROS1, C4A, PLAU, F2R, TFPI, A2M, C3",0.515700160653214,0.22112552799726,FALSE
+"H1975","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.38729,1.15,0.277,2745,0.586,"TAT, LDHA, CTH, SMS, LDHB, SDS, MPST, SRM, MTR, AHCY",0.557520230935551,0.232102383981909,FALSE
+"H1975","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.31713,-0.955,0.473,8918,0.67,"IL1R1, TNFSF13B, LIF, TGFB1, IL6, TNFRSF21, INHBA, CXCR4, TNFRSF11B, CX3CL1, CXCL5, NGFR",0.325138859262188,0.173925197299174,FALSE
+"H1975","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.25405,-0.783,0.743,9336,0.858,"TREX1, IL6, ZBP1",0.129011186239425,0.0665127121512946,FALSE
+"H1975","Input","KEGG_DILATED_CARDIOMYOPATHY",0.40717,1.21,0.215,257,0.581,"MYH7, TNNC1, ITGB3, DES, PRKACA, ITGA5, TPM4",0.667561540084395,0.235823867609669,FALSE
+"H1975","Input","KEGG_DNA_REPLICATION",-0.61634,-1.91,0.0182,7089,0.229,"RPA3, POLE3, MCM5, RNASEH2B, LIG1, RFC3, PRIM1, POLA1, MCM2, FEN1, POLD1, MCM7, POLD3, POLA2, RFC4, MCM4, MCM6, MCM3, POLE, POLD2, RNASEH2C, PRIM2, POLE2",1.73992861201493,0.640164517660112,TRUE
+"H1975","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.15728,0.477,1,2797,1,"ETS1, MAPK1, SPIRE1, SOS2",0,0,FALSE
+"H1975","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.47746,1.47,0.0871,895,0.866,"ALDH3B1, MAOB, GSTP1, GSTA5, GSTM2, CYP3A4, GSTZ1",1.05998184499234,0.0624821079826534,FALSE
+"H1975","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.48953,1.51,0.0784,1671,0.905,"UPP1, CDA, IMPDH1, CYP3A4, TYMP, UCKL1, DPYD, IMPDH2",1.10568393731556,0.0433514207947967,FALSE
+"H1975","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.41838,1.25,0.2,580,0.56,"FN1, COL5A1, TNC, ITGB3, COL1A2, ITGA5, THBS2, CD44, SDC4, COL6A1, THBS1, COL1A1",0.698970004336019,0.2518119729938,FALSE
+"H1975","Input","KEGG_ENDOCYTOSIS",0.31138,0.939,0.494,3371,0.637,"EHD2, SH3KBP1, ASAP3, F2R, EPN1, CHMP2A, RAB31, ITCH, IQSEC2, SH3GL1, RABEP1, EHD4, PSD3, DNM2, SMURF1, ASAP2, PLD2, STAM, ARFGAP1, ARFGAP3, IQSEC1, RBSN, GRK2, RAB11FIP5, PDCD6IP, GIT2, RAB5B, DNM1, CHMP3, ACAP2, DNAJC6, VPS37A, DNM1L, VPS4A, SH3GLB1, HSPA2, ARRB1, EEA1, AGAP1, PSD4, CHMP2B, PSD, RAB5A, SMURF2, CBL, ASAP1, RAB11FIP1, RAB11FIP2, WWP1, TSG101, PLD1, NEDD4L, STAM2, RAB22A, VPS4B, RAB5C, RNF41, GIT1, TRAF6, VPS25, ARF6, EPN3, EHD3",0.306273051076353,0.19586056766465,FALSE
+"H1975","Input","KEGG_ENDOMETRIAL_CANCER",0.41013,1.25,0.202,2283,0.56,"TP53, MYC, PTEN, AKT1, ARAF, MAP2K2, RAF1, PIK3R2, PIK3CA, ILK, MAPK1, FOXO3, APC, TCF7L1, PDPK1, BRAF",0.694648630553376,0.2518119729938,FALSE
+"H1975","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.35618,1.06,0.336,3667,0.606,"PLCG2, MAPK10, MAPK8, MAP2K4, IKBKG, PAK1, LYN, CHUK, IKBKB, ATP6V1C1, NFKB1, ATP6V1G1, ATP6V1D, ATP6V1E1, ATP6V1B2, TCIRG1, MAPK14, ATP6V1B1, MAPK9, GIT1, ATP6V1H, PLCG1, RELA, CASP3, ATP6V1F, TJP1, ADAM17, ATP6V1A",0.473660722610156,0.217527375833714,FALSE
+"H1975","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.41338,1.26,0.179,2804,0.584,"PAK5, PAK6, PRKCA, MYC, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, CDKN1B, STAT5A, MAPK10, RPS6KB2, MAPK8, CDKN1A, MAP2K4, PIK3CA, PAK1, MAPK1, CRK, BRAF, ABL2, PAK3, CRKL, CAMK2G, AREG, CBL, CAMK2D, SOS2, PAK2",0.747146969020107,0.233587152887601,FALSE
+"H1975","Input","KEGG_ETHER_LIPID_METABOLISM",-0.30959,-0.943,0.471,8863,0.676,"PLA2G2D, PAFAH1B3, PLA2G4A, PLA2G2A",0.326979092871104,0.170053304058364,FALSE
+"H1975","Input","KEGG_FATTY_ACID_METABOLISM",-0.31974,-0.988,0.44,7467,0.675,"ACADM, ALDH7A1, HADH, HADHA, ACADS, ECI1, ALDH3A2, ACAT2, ACOX3, ACSL6, CPT1A, ACOX1, ALDH2, ACADL, ADH1C",0.356547323513813,0.170696227168975,FALSE
+"H1975","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.36516,1.09,0.315,1781,0.616,"RAC2, PLA2G6, PRKCA, VAV2, VAV1, AKT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, MAPK10, PRKCD, MAPK8, MAP2K4, PIK3CA, FYN, LYN, MAPK1",0.501689446210399,0.210419287835575,FALSE
+"H1975","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.42379,1.27,0.165,2241,0.58,"RAC2, PLA2G6, PRKCA, ASAP3, LIMK1, WASF1, VAV2, VAV1, AKT1, PLPP2, MYO10, DNM2, PRKCB, PLCG2, RAF1, PIK3R2, ASAP2, PLD2, PLPP1, PRKCD, RPS6KB2, PIK3CA, PAK1, DNM1, LYN, HCK, MAPK1, DNM1L, MARCKS, ARPC4, ARPC5L, CRK, ARPC1A",0.782516055786094,0.236572006437063,FALSE
+"H1975","Input","KEGG_FOCAL_ADHESION",0.44046,1.31,0.152,1658,0.629,"FN1, COL5A1, TNC, ITGB3, RAC2, CAV2, MYLK, CAV1, PAK5, PAK6, PRKCA, COL1A2, ITGA5, THBS2, FLNA, MYL9, COL6A1, THBS1, ZYX, PARVA, VAV2, VAV1, PTEN, AKT1, COL1A1, TLN2, FLNC, ACTN3, MYL12A, PRKCB, RAF1, PIK3R2, ARHGAP5, BCAR1, MAPK10, TLN1, MAPK8, VCL, CAPN2, ACTN1, PIK3CA, ITGA3, PAK1, ILK, FYN",0.818156412055227,0.201349354554731,FALSE
+"H1975","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.35669,-1.1,0.296,7275,0.56,"ALPI, ALPP, ALPL, GGH, DHFR",0.528708288941061,0.2518119729938,FALSE
+"H1975","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.52992,1.6,0.0531,2937,0.931,"AKR1B1, ALDOB, ALDOC, FBP2, FBP1, PFKFB4, MTMR1, GMPPA, MTMR6, GMPPB, HK2, PFKP, SORD, HK3, PFKM, PHPT1, ALDOA",1.27490547891853,0.0310503190186574,FALSE
+"H1975","Input","KEGG_GALACTOSE_METABOLISM",0.31091,0.939,0.499,3748,0.637,"AKR1B1, HK2, B4GALT1, PFKP, PGM2, MGAM, HK3, PFKM, GAA, GLB1, GALK1, PFKL, UGP2, GALE",0.30189945437661,0.19586056766465,FALSE
+"H1975","Input","KEGG_GAP_JUNCTION",0.35606,1.08,0.333,1189,0.614,"TUBA4A, PRKACA, PRKCA, GJA1, TUBB6, ITPR1, ADCY7, PRKCB, MAP2K2, RAF1, GNA11, GNAI2, TUBA3C",0.47755576649368,0.211831628858832,FALSE
+"H1975","Input","KEGG_GLIOMA",0.39706,1.2,0.231,1471,0.575,"TP53, PRKCA, PTEN, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, CDKN1A, PIK3CA",0.636388020107856,0.24033215531037,FALSE
+"H1975","Input","KEGG_GLUTATHIONE_METABOLISM",0.43351,1.28,0.162,1882,0.613,"ANPEP, GSTP1, GSTA5, GGT1, GSTM2, GPX4, GSS, GSTZ1, SMS, GGT7, RRM1, GPX3, G6PD",0.790484985457369,0.212539525481585,FALSE
+"H1975","Input","KEGG_GLYCEROLIPID_METABOLISM",0.34322,1.03,0.348,1674,0.602,"AKR1B1, AGPAT4, MGLL, PLPP2, DGKA, PLPP1, CEL, DGKB, GPAT3, DGKQ, GPAM",0.458420756053419,0.220403508742175,FALSE
+"H1975","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.31557,0.935,0.505,1674,0.638,"PLA2G6, AGPAT4, PLPP2, DGKA, PTDSS1, LPCAT1, MBOAT7, PLD2, PLPP1, DGKB, CHKB, GPAT3, CDS2, DGKQ, CHKA, GPAM",0.296708621881339,0.195179321278838,FALSE
+"H1975","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.57847,1.72,0.029,1465,1,"SARDH, MAOB, SHMT1, SRR, CTH, GATM, MAOA, PSAT1",1.53760200210104,0,FALSE
+"H1975","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.32299,0.998,0.436,2937,0.612,"ALDH3B1, ALDOB, LDHA, ALDOC, GALM, PGK2, FBP2, ACSS1, FBP1, PGAM1, PGAM4, PGK1, PKM, LDHB, HK2, GPI, PFKP, PGM2, HK3, ALDH9A1, PFKM, ENO2, PKLR, ALDH1B1, ALDOA",0.360513510731414,0.213248577854439,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.42066,-1.25,0.204,8932,0.433,"CHSY3, XYLT1",0.690369832574101,0.363512103646635,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.46541,-1.4,0.113,7497,0.426,"HS2ST1, GLCE, EXTL2, XYLT1",0.94692155651658,0.370590400897281,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.3595,-1.11,0.292,9017,0.56,"B4GAT1, B4GALT4, B3GNT2",0.534617148551582,0.2518119729938,FALSE
+"H1975","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.23143,-0.702,0.847,7944,0.917,"HPSE, ARSB, GUSB, HEXA",0.0721165896692931,0.0376306643299789,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.28895,0.871,0.583,4039,0.696,"B4GALNT1, ST3GAL2, GLB1, HEXB, SLC33A1, ST3GAL1",0.234331445240986,0.157390760389438,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.3233,0.986,0.428,526,0.618,"B3GALT5",0.368556230986828,0.209011524911184,FALSE
+"H1975","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.42236,-1.28,0.175,7885,0.441,"B4GALT3, B3GNT3, B4GAT1, ST3GAL4, B4GALT4, B3GNT2",0.756961951313706,0.355561410532161,FALSE
+"H1975","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.14942,-0.448,1,6278,0.998,"PIGU, PIGS, PIGX, PIGT, GPAA1, PIGK, PIGO",0,0.000869458712628891,FALSE
+"H1975","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.309,0.943,0.482,2512,0.644,"MTHFD1, HYI, PGP",0.31695296176115,0.191114132640188,FALSE
+"H1975","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.25085,0.761,0.768,1424,0.851,"PLA2G6, PRKACA, PRKCA, ITPR1, ADCY7, PRKCB, MAP2K2, MMP14, RAF1, GNA11, PLD2, MAPK10, PRKCD, MAPK8, CACNA1F, MAP2K4, PTK2B",0.114638779968488,0.0700704399154121,FALSE
+"H1975","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.36442,1.12,0.308,1117,0.599,"PRKACA, WNT5B, FBXW11",0.511449283499556,0.222573177610689,FALSE
+"H1975","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.4457,1.34,0.137,286,0.685,"ANPEP, ITGB3, ITGA5, CD44, CSF1",0.863279432843593,0.164309428507574,FALSE
+"H1975","Input","KEGG_HISTIDINE_METABOLISM",0.38017,1.16,0.261,1308,0.59,"ALDH3B1, MAOB, HNMT, TRMT11, MAOA",0.583359492661719,0.229147988357856,FALSE
+"H1975","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.5707,-1.76,0.0292,7933,0.296,"BRCA2, POLD1, POLD3, EME1, RAD52, POLD2, MUS81, RAD54B, MRE11, BLM, RAD51",1.53461714855158,0.528708288941061,FALSE
+"H1975","Input","KEGG_HUNTINGTONS_DISEASE",-0.15189,-0.462,1,6482,1,"TBP, POLR2J, SOD1, BBC3, SIN3A, COX7B, CASP9, ATP5PB, ATP5F1C, UQCRH, VDAC1, NDUFB10, POLR2G, ATP5F1B, CREB1, SDHB, SP1, UQCRQ, HDAC2, COX7A2, ATP5PO, NDUFA4, POLR2D, COX6B1, RCOR1, SLC25A5, GRM5, COX5B, VDAC3, POLR2K, ATP5F1D, POLR2E, POLR2L, UQCRFS1, UQCRC2, POLR2C, COX5A, ATP5PF, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, PLCB2, CYC1, ATP5PD, SLC25A4, POLR2I, SOD2, UQCRB, REST, POLR2F, PLCB4, PLCB1",0,0,FALSE
+"H1975","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.3829,1.17,0.237,468,0.583,"MYH7, TNNC1, ITGB3, DES, ITGA5, PRKAB2, TPM4, ACE",0.625251653989896,0.234331445240986,FALSE
+"H1975","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.23182,-0.692,0.841,8770,0.916,"ITPK1, ISYNA1, INPP1, PLCB4, INPP5B, PLCB1, ITPKA",0.0752040042020878,0.0381045263321496,FALSE
+"H1975","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.39026,1.15,0.253,2488,0.586,"PYGL, PYGB, PRKACA, PRKAB2, SORBS1, PRKAR1B, AKT1, ARAF, PHKA1, PRKAG2, TRIP10, MAP2K2, FBP2, EIF4E2, RAF1, FBP1, PIK3R2, PHKB, MAPK10, RPS6KB2, MAPK8, RHEB, PIK3CA, ACACA, TSC1, TSC2, EXOC7, ACACB, MAPK1, IRS1, IKBKB, HK2, PRKAR1A, PRKACB, RAPGEF1, PRKAR2A, PDPK1, PHKG2, CRK, BRAF, PHKA2, IRS2, HK3, CRKL",0.596879478824182,0.232102383981909,FALSE
+"H1975","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.63372,-1.95,0.0127,9030,0.24,"TNFSF13B, TGFB1, IL6, CXCR4",1.89619627904404,0.619788758288394,TRUE
+"H1975","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.20607,0.627,0.951,1618,0.987,"MYC, STAT6, AKT1, OSMR, TYK2, PIK3R2, STAT5A, STAM, PIK3CA, LIFR, STAT2",0.0218194830625861,0.00568284733036327,FALSE
+"H1975","Input","KEGG_LEISHMANIA_INFECTION",-0.23201,-0.717,0.823,8989,0.91,"TLR2, TGFB1, PTGS2, FOS",0.0846001647877302,0.0409586076789064,FALSE
+"H1975","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.39867,1.18,0.229,1471,0.588,"RAC2, PRKCA, MSN, MYL9, ICAM1, VAV2, VAV1, CYBA, CLDN4, ACTN3, MYL12A, PRKCB, PLCG2, PIK3R2, ARHGAP5, GNAI2, BCAR1, CLDN16, CLDN6, VCL, ACTN1, PTK2B, PIK3CA",0.640164517660112,0.230622673923862,FALSE
+"H1975","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.40122,-1.25,0.191,7529,0.433,"ALDH7A1, HADHA, ALDH3A2, YOD1, ALDH2",0.718966632752272,0.363512103646635,FALSE
+"H1975","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.51809,-1.61,0.0467,8351,0.328,"PLA2G12A, PLA2G2D, CYP2J2, PLA2G4A, PLA2G2A",1.33068311943389,0.484126156288321,FALSE
+"H1975","Input","KEGG_LONG_TERM_DEPRESSION",0.35499,1.07,0.321,1076,0.624,"PLA2G6, PRKCA, CACNA1A, ITPR1, ARAF, GNA13, PRKCB, MAP2K2, RAF1, GNA11, GNA12, GNAI2",0.493494967595128,0.204815410317576,FALSE
+"H1975","Input","KEGG_LONG_TERM_POTENTIATION",0.42164,1.25,0.181,932,0.56,"PRKACA, PRKCA, RPS6KA6, ITPR1, RPS6KA3, RPS6KA2, ARAF, PRKCB, MAP2K2, RAF1",0.742321425130815,0.2518119729938,FALSE
+"H1975","Input","KEGG_LYSINE_DEGRADATION",-0.48523,-1.47,0.0952,7368,0.381,"SETD1A, DLST, ASH1L, ALDH7A1, HADH, HADHA, SETD1B, DOT1L, EHMT1, ALDH3A2, EHMT2, ACAT2, SETDB2, NSD3, SUV39H2, SETDB1, AADAT, NSD1, KMT5A, ALDH2, SUV39H1, NSD2, AASS, BBOX1, TMLHE",1.02136305161553,0.419075024324381,FALSE
+"H1975","Input","KEGG_LYSOSOME",0.32882,0.983,0.446,2438,0.609,"ACP5, GALC, AP3S1, CTSF, AP3D1, AP3M2, AP1M2, IGF2R, AP3B1, IDS, LIPA, AP1S2, AP3M1, CTSA, AP1M1, LGMN, AP1S3, CTSB, LAMP2, CD63, NPC2, NAGPA, CTSL, AP1S1, AP1B1, AP4E1, SMPD1, LAMP3, AP1G1, GALNS, GGA1, AP4B1",0.350665141287858,0.215382707367125,FALSE
+"H1975","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.29461,0.868,0.582,2237,0.695,"RAC2, TP53, PLA2G6, PRKACA, PRKCA, MOS, CACNA1A, FLNA, RPS6KA6, RAPGEF2, RPS6KA3, MYC, HSPB1, RPS6KA2, AKT1, RASA1, PPM1B, FLNC, RRAS2, PTPN7, PRKCB, MAP2K2, DUSP9, RAF1, MAPT, GNA12, MAPKAPK3, TAB1, MAPK10, MAPK8, CACNA1F, MAP2K4, CD14, MAP3K7, IKBKG, MAP4K3, PAK1, MAPK7, PPP3CA, PPM1A, MAPK1, MAP3K5, CHUK, IKBKB, MAP3K4, PPP3CB, TAB2, PRKACB, TGFBR1, MAPK8IP3, HSPA2, ARRB1, NFKB1, CRK, TAOK3",0.235077015350112,0.158015195409886,FALSE
+"H1975","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.72945,-2.22,0.00935,8319,0.258,"HES1, PDX1, HNF1A, HNF4A, PAX6",2.02918838912748,0.58838029403677,FALSE
+"H1975","Input","KEGG_MELANOGENESIS",0.34859,1.05,0.346,1076,0.59,"FZD2, PRKACA, PRKCA, MITF, WNT5B, ADCY7, DVL1, PRKCB, MAP2K2, DVL2, RAF1, GNAI2",0.460923901207223,0.229147988357856,FALSE
+"H1975","Input","KEGG_MELANOMA",-0.33141,-1.04,0.33,9908,0.613,"FGF13, FGF2",0.481486060122112,0.212539525481585,FALSE
+"H1975","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.38893,1.19,0.237,895,0.581,"ALDH3B1, GSTP1, GSTA5, CYP1B1, GSTM2, CYP3A4, GSTZ1",0.625251653989896,0.235823867609669,FALSE
+"H1975","Input","KEGG_MISMATCH_REPAIR",-0.37846,-1.15,0.266,6634,0.51,"RFC2, PCNA, MSH3, RPA3, MSH6, MSH2, LIG1, RFC3, POLD1, POLD3, RFC4, POLD2, EXO1",0.575118363368933,0.292429823902064,FALSE
+"H1975","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.45627,1.39,0.116,2440,0.688,"RPS6KA6, RPS6KA3, RPS6KA2, AKT1, CAB39, EIF4E2, PIK3R2, RICTOR, STRADA, RPS6KB2, RHEB, PIK3CA, TSC1, TSC2, MAPK1, EIF4B, VEGFA, PDPK1, BRAF, ULK1",0.935542010773082,0.162411561764489,FALSE
+"H1975","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.52797,1.63,0.0455,1904,0.974,"ICAM2, RAC2, PRKCA, ICAM1, MICA, VAV2, VAV1, ARAF, ULBP1, RAET1L, ULBP2, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, PRF1, TNFRSF10D, PTK2B, PIK3CA, PAK1, FYN, PPP3CA, MAPK1, ULBP3, PPP3CB",1.34198860334289,0.0114410431213845,FALSE
+"H1975","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.4103,1.24,0.204,818,0.565,"F2R, F2RL1, NR3C1",0.690369832574101,0.247951552180562,FALSE
+"H1975","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.34476,1.04,0.366,2495,0.601,"TP53, RPS6KA6, RPS6KA3, RPS6KA2, RIPK2, AKT1, MAP2K2, PLCG2, RAF1, PIK3R2, YWHAH, IRAK4, MAPK10, PRKCD, IRAK1, MAPK8, PIK3CA, MAPK7, MAGED1, MAPK1, IRS1, MAP3K5, IKBKB, FOXO3, IRAK2, RAPGEF1, PDPK1, NFKB1, CRK, BRAF, IRS2, CRKL, CAMK2G",0.436518914605589,0.22112552799726,FALSE
+"H1975","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.4539,1.39,0.112,1122,0.688,"NNMT, NAMPT, ENPP1, NT5C2, NT5E",0.950781977329818,0.162411561764489,FALSE
+"H1975","Input","KEGG_NITROGEN_METABOLISM",0.34057,1.02,0.384,1268,0.588,"CA12, CA9, ASNS, CTH, CPS1",0.415668775632469,0.230622673923862,FALSE
+"H1975","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.49777,1.47,0.0869,2233,0.866,"TRIP6, RIPK2, CASP8, PYDC1, TAB1, MAPK10, MAPK8, ERBIN, TAB3, MAP3K7, IKBKG, XIAP, MAPK1, CHUK, IKBKB, TAB2, NFKB1",1.06098022355133,0.0624821079826534,FALSE
+"H1975","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.45163,-1.39,0.122,8146,0.416,"FEN1, LIG4, MRE11",0.913640169325252,0.380906669373257,FALSE
+"H1975","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.30867,0.934,0.494,949,0.633,"TP53, PRKCA, AKT1, ARAF, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2",0.306273051076353,0.198596289982645,FALSE
+"H1975","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.22824,0.686,0.88,1347,0.944,"DVL1, DVL2, DTX3L, JAG1",0.0555173278498314,0.025028005701931,FALSE
+"H1975","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.37218,-1.16,0.258,7879,0.529,"LIG1, RFC3, GTF2H1, POLD1, CUL4A, POLD3, RFC4, POLE, POLD2, ERCC1, POLE2, GTF2H5, DDB2",0.58838029403677,0.276544327964814,FALSE
+"H1975","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.25682,-0.78,0.724,7008,0.847,"DPAGT1, GANAB, ALG9, MOGS, MAN1A2, B4GALT3, ALG8, MAN2A2, ALG6, MGAT5, ALG5, ALG13, ALG14, MGAT4A",0.140261433802853,0.0721165896692931,FALSE
+"H1975","Input","KEGG_OLFACTORY_TRANSDUCTION",0.35894,1.06,0.367,2730,0.606,"PRKACA, PRKACB, CAMK2G, CAMK2D",0.435333935747911,0.217527375833714,FALSE
+"H1975","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.44693,-1.34,0.147,9163,0.418,"DHFR, TYMS, ALDH1L1",0.832682665251824,0.378823718224965,FALSE
+"H1975","Input","KEGG_OOCYTE_MEIOSIS",0.22653,0.688,0.858,1904,0.95,"PRKACA, MOS, RPS6KA6, ITPR1, RPS6KA3, SMC1B, RPS6KA2, AR, ADCY7, YWHAH, FBXW11, PPP2R5E, PPP2R5B, SLK, PPP3CA, MAPK1, PPP2CB, PPP3CB",0.0665127121512946,0.0222763947111523,FALSE
+"H1975","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.43007,-1.32,0.162,7313,0.425,"GBA, MAN2B2, MANBA, HEXA, FUCA1",0.790484985457369,0.371611069949688,FALSE
+"H1975","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.17496,-0.547,0.979,6631,1,"COX7B, ATP5ME, ATP5PB, ATP5F1C, UQCRH, ATP5MG, NDUFB10, ATP5F1B, COX11, SDHB, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, COX5B, ATP5F1D, UQCRFS1, UQCRC2, ATP12A, COX5A, ATP5PF, COX7A2L, UQCRC1, NDUFA5, ATP5F1E, CYC1, ATP5PD, UQCRB, PPA2",0.00921730819686218,0,FALSE
+"H1975","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.2724,0.805,0.699,1894,0.794,"GALNT12, GALNT6, GALNT13, GALNT7, GALNT10, GALNT16, GALNT17",0.155522824254319,0.100179497572904,FALSE
+"H1975","Input","KEGG_P53_SIGNALING_PATHWAY",0.32705,0.961,0.476,586,0.619,"SERPINE1, TP53, STEAP3, THBS1, TP53I3, PTEN, CASP8",0.322393047279507,0.208309350979882,FALSE
+"H1975","Input","KEGG_PANCREATIC_CANCER",0.34523,1.03,0.378,2364,0.602,"RAC2, TP53, AKT1, RALB, ARAF, RAF1, PIK3R2, MAPK10, MAPK8, PIK3CA, RALA, IKBKG, MAPK1, CHUK, IKBKB, VEGFA, SMAD4, TGFBR1, CDK4, NFKB1, BRAF, RALBP1",0.422508200162775,0.220403508742175,FALSE
+"H1975","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.35781,1.08,0.332,2175,0.614,"ENPP1, PANK2, DPYD, PANK1",0.478861916295964,0.211831628858832,FALSE
+"H1975","Input","KEGG_PARKINSONS_DISEASE",-0.27786,-0.871,0.561,6631,0.75,"COX7B, CASP9, ATP5PB, ATP5F1C, UQCRH, VDAC1, NDUFB10, UBE2J1, ATP5F1B, SDHB, UQCRQ, COX7A2, ATP5PO, NDUFA4, COX6B1, SLC25A5, COX5B, VDAC3, ATP5F1D, UQCRFS1, UQCRC2, COX5A, HTRA2, ATP5PF, COX7A2L, PARK7, UQCRC1, NDUFA5, ATP5F1E, CYC1, ATP5PD, SLC25A4, UBE2J2, UQCRB, UBE2G2, UCHL1, SNCA",0.251037138743839,0.1249387366083,FALSE
+"H1975","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.34842,1.05,0.363,3542,0.59,"LY96, TUBA4A, PRKCA, TUBB6, TUBA3C, CD14, FYN, ARHGEF2, ARPC4, ARPC5L, CTTN, TUBB4B, ARPC1A, ARPC2, TUBA1C, TUBB3, TUBB1, CTNNB1, CDH1, ROCK2, ARPC3, ARPC1B, YWHAQ, ABL1, ARPC5, TUBA1B",0.440093374963888,0.229147988357856,FALSE
+"H1975","Input","KEGG_PATHWAYS_IN_CANCER",-0.31115,-0.959,0.449,9314,0.678,"TGFB1, AXIN2, LAMA5, IL6, SLC2A1, COL4A1, RET, WNT10A, RASSF5, TGFA, RAD51, MMP1, FZD1, SKP2, CEBPA, PML, BIRC5, FGFR2, PTGS2, FOS, LAMB4, LAMB1, MMP2, COL4A2, FGF13, FGF2",0.347753658996677,0.168770306132937,FALSE
+"H1975","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.44533,1.34,0.139,2209,0.685,"AKR1B1, XYLB, UGDH, CRYL1",0.856985199745905,0.164309428507574,FALSE
+"H1975","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.55606,1.7,0.0274,2962,0.881,"ALDOB, RBKS, ALDOC, FBP2, FBP1, PGLS, PRPS1, PRPS1L1, GPI, G6PD, PFKP, PGM2, PFKM, PRPS2, ALDOA, DERA",1.56224943717961,0.0550240915879521,FALSE
+"H1975","Input","KEGG_PEROXISOME",-0.29213,-0.916,0.521,8264,0.711,"PEX11A, PRDX5, ACOX3, PHYH, SOD2, ABCD3, PEX2, ACSL6, ACOX1, PEX14, HSD17B4, SLC27A2, IDH2, NUDT19, ECH1",0.283162276700476,0.148130399270234,FALSE
+"H1975","Input","KEGG_PHENYLALANINE_METABOLISM",0.60139,1.82,0.0251,375,0.894,"ALDH3B1, MAOB, TAT, MIF",1.60032627851896,0.0486624812040823,FALSE
+"H1975","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.3277,0.994,0.451,2600,0.612,"PRKCA, ITPR1, IMPA2, PIP4K2A, PTEN, PIP4K2C, DGKA, SYNJ2, PRKCB, PLCG2, PIK3R2, PI4KA, DGKB, CDS2, PIK3CA, DGKQ, INPP4A, INPP5E, INPP5A, ITPR3, PLCD1, CDIPT, PI4KB, PIK3C3, INPPL1, INPP5K",0.345823458122039,0.213248577854439,FALSE
+"H1975","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.25598,-0.776,0.727,7977,0.839,"UROS, FECH, GUSB, MMAB, BLVRB, CP",0.138465589140962,0.0762380391712997,FALSE
+"H1975","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.33577,1.02,0.39,574,0.588,"CYP27A1, ANGPTL4, PLTP, ACSL4, SORBS1, ME1, PPARG",0.408935392973501,0.230622673923862,FALSE
+"H1975","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.46509,1.39,0.115,24,0.688,"CYP27A1",0.939302159646388,0.162411561764489,FALSE
+"H1975","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.44325,1.33,0.135,653,0.654,"CD79A, CD40, ADA, TAP1",0.869666231504994,0.184422251675733,FALSE
+"H1975","Input","KEGG_PRION_DISEASES",-0.28228,-0.875,0.568,9350,0.758,"IL6, NCAM1, C9",0.245651664288981,0.120330794367946,FALSE
+"H1975","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.29922,0.916,0.508,1471,0.643,"PRKACA, MOS, RPS6KA6, RPS6KA3, RPS6KA2, AKT1, ARAF, ADCY7, RAF1, PIK3R2, GNAI2, MAPK10, MAPK8, PIK3CA",0.294136287716081,0.191789027075778,FALSE
+"H1975","Input","KEGG_PROPANOATE_METABOLISM",-0.27114,-0.825,0.666,7467,0.809,"ACADM, ALDH6A1, ALDH7A1, HADHA, ABAT, ALDH3A2, ACAT2, HIBCH, ACSS3, ALDH2, MCEE",0.176525770829699,0.0920514783877277,FALSE
+"H1975","Input","KEGG_PROSTATE_CANCER",0.30764,0.922,0.508,2391,0.639,"GSTP1, TP53, PTEN, AKT1, ARAF, AR, MAP2K2, RAF1, PIK3R2, CDKN1B, CREB5, CDKN1A, PIK3CA, IKBKG, MAPK1, CHUK, IKBKB, TCF7L1, PDPK1, NFKB1, BRAF, CCNE1",0.294136287716081,0.1944991418416,FALSE
+"H1975","Input","KEGG_PROTEASOME",0.33695,1.02,0.373,3414,0.588,"PSMB9, PSMB10, PSMF1, SEM1, PSMB8, PSME4, PSMB4, PSMD14, PSMD11, PSMD3, PSMD7, PSMD6, PSMD12, PSMD13",0.428291168191312,0.230622673923862,FALSE
+"H1975","Input","KEGG_PROTEIN_EXPORT",-0.54391,-1.69,0.0451,7537,0.302,"HSPA5, SEC61A2, SRPRA, SPCS3, SEC11A, SPCS2, SRPRB, IMMP2L, SRP14, SPCS1, SRP9",1.34582345812204,0.519993057042849,FALSE
+"H1975","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.58648,-1.8,0.0242,7805,0.3,"ATP1A4, ATP1A1, ATP1A3, PCK2, SLC4A4, ATP1B1, CA2, GLUD2",1.61618463401957,0.522878745280338,FALSE
+"H1975","Input","KEGG_PURINE_METABOLISM",0.26498,0.785,0.732,1198,0.824,"PDE5A, PDE4A, PDE4D, PAPSS2, ADSL, NME7, PFAS, ENPP1, AMPD3, ADA, ENTPD3, NT5C2, IMPDH1, AMPD1, ADCY7, ADK, NT5E, NME4, GMPR",0.135488918941608,0.0840727883028842,FALSE
+"H1975","Input","KEGG_PYRIMIDINE_METABOLISM",0.21891,0.673,0.9,1128,0.952,"UPP1, CDA, NME7, ENTPD3, NT5C2, TYMP, NT5E, NME4",0.0457574905606751,0.0213630516155257,FALSE
+"H1975","Input","KEGG_PYRUVATE_METABOLISM",0.29567,0.906,0.539,1756,0.654,"AKR1B1, ME1, LDHA, HAGHL, ACSS1, ACACA, PKM, LDHB, ACACB",0.268411234813261,0.184422251675733,FALSE
+"H1975","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.36929,1.12,0.274,1675,0.599,"FN1, ITGB3, RAC2, MYLK, PAK5, PAK6, ITGA5, MOS, MSN, MYL9, DIAPH2, MYH9, LIMK1, F2R, WASF1, VAV2, PIP4K2A, VAV1, ARAF, ENAH, PIP4K2C, ACTN3, GNA13, RRAS2, MYL12A, MYH10, MAP2K2, RAF1, PIK3R2, GNA12, SSH3, BCAR1, VCL, ACTN1, CD14, PIK3CA, ITGA3, PAK1, ARHGEF4, SSH2",0.562249437179612,0.222573177610689,FALSE
+"H1975","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.38118,-1.16,0.268,9894,0.529,"PRKAA2",0.571865205971211,0.276544327964814,FALSE
+"H1975","Input","KEGG_RENAL_CELL_CARCINOMA",0.33092,0.98,0.437,3029,0.6,"PAK5, PAK6, AKT1, ARAF, ETS1, MAP2K2, RAF1, PIK3R2, FLCN, PIK3CA, PAK1, MAPK1, VEGFA, RAPGEF1, CRK, BRAF, PAK3, CRKL, TGFB2, SOS2, PAK2, VHL, EGLN1",0.359518563029578,0.221848749616356,FALSE
+"H1975","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.67973,2.04,0.00546,518,0.433,"ANPEP, CPA3, ACE, THOP1",2.26280735729526,0.363512103646635,FALSE
+"H1975","Input","KEGG_RETINOL_METABOLISM",-0.65655,-2.01,0.0137,8808,0.368,"DHRS3, RDH10, DGAT1, ADH1C, DHRS9, ALDH1A1",1.86327943284359,0.434152181326482,FALSE
+"H1975","Input","KEGG_RIBOFLAVIN_METABOLISM",0.69332,2.06,0.00852,1404,0.768,"ACP5, ENPP1, MTMR1, MTMR6",2.0695604052333,0.114638779968488,FALSE
+"H1975","Input","KEGG_RIBOSOME",0.42905,1.31,0.146,4061,0.629,"RPS25, RPL37, RPL22L1, RPL29, RPS10, FAU, RPS7, RPS15, RPL27, RPS16, RPS26, RPS15A, RPL4, RPL37A, RPL21, RPS24, RPS8, RPL24, RSL24D1, RPL28, RPS9, RPL35A, RPS13, RPL14, UBA52, RPL35, RPL30, RPS21, RPL10, RPL36, RPS11, RPS5, RPS19, RPL8, RPL9, RPL3, RPL32, RPS3A, RPS3, RPL18A, RPL6, RPS18, RPL31, RPL26, RPS2, RPS20, RPS4X, RPL13A, RPL12, RPL5, RPL22, RPS23, RPL34, RPS28, RPL18, RPL15, RPLP0, RPL17, RPL11, RPL36A, RPL36AL, RPL23A, RPS27L, RPL7A, RPL7, RPL10A",0.835647144215563,0.201349354554731,FALSE
+"H1975","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.48878,1.45,0.1,3047,0.698,"TBKBP1, CASP8, DHX58, TRADD, DDX58, IFIH1, MAPK10, ISG15, MAPK8, TRIM25, IRF7, MAVS, MAP3K7, IKBKG, OTUD5, ATG12, CHUK, IKBKB, FADD, NFKB1, RIPK1, TRAF3, MAPK14, CASP10, MAPK9, ATG5",1,0.156144577376839,FALSE
+"H1975","Input","KEGG_RNA_DEGRADATION",0.1707,0.514,0.996,7870,1,"EDC3, TTC37, PATL1, SKIV2L, PAPOLA, EDC4, CNOT4, XRN1, ZCCHC7, C1D, ENO2, DCP1A, MPHOSPH6, CNOT1, DCP1B, CNOT7, DDX6, ENO1, CNOT9, CNOT3, PARN, CNOT10, EXOSC7, EXOSC10, CNOT2, XRN2, MTREX, LSM1, DIS3, CNOT6L, HSPD1, HSPA9, LSM7, EXOSC3, CNOT6, WDR61, EXOSC2, CNOT8, EXOSC4, TENT4A, PAPOLG, LSM2, LSM6, LSM4, EXOSC1, EXOSC9, EXOSC5, EXOSC6, DCPS, ENO3, EXOSC8, LSM8, DCP2, LSM3",0.00174066157630127,0,FALSE
+"H1975","Input","KEGG_RNA_POLYMERASE",-0.51817,-1.58,0.0733,5450,0.333,"POLR1A, POLR2H, POLR3G, POLR3H, POLR3C, POLR3GL, POLR2B, POLR1B, POLR3K, POLR2J, POLR3F, POLR2G, POLR2D, POLR1C, POLR1D, POLR2K, POLR2E, POLR2L, POLR2C, POLR1E, POLR2I, POLR2F",1.13489602535887,0.47755576649368,FALSE
+"H1975","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.50335,1.55,0.0632,1497,0.98,"GGT1, PAPSS2, CTH, TRMT11, SCLY, GGT7",1.19928292171761,0.00877392430750515,FALSE
+"H1975","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.35355,-1.09,0.29,8221,0.543,"PIK3R1, COL4A6, RB1, CKS1B, TRAF4, PIAS1, ITGA6, RXRB, E2F3, BCL2L1, LAMA5, COL4A1, SKP2, PTGS2, FHIT, LAMB4, LAMB1, COL4A2",0.537602002101044,0.265200170411153,FALSE
+"H1975","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.30308,0.892,0.549,2934,0.666,"STX2, STX8, STX10, YKT6, VTI1B, SNAP29, STX3, BET1, VTI1A, STX4, VAMP7, STX12, USE1",0.260427655549908,0.176525770829699,FALSE
+"H1975","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.28537,-0.892,0.531,9899,0.74,"SMPD3",0.274905478918531,0.130768280269024,FALSE
+"H1975","Input","KEGG_SPLICEOSOME",-0.48324,-1.45,0.107,5796,0.383,"SRSF6, CDC5L, SNRPD3, PPIL1, SRSF5, BUD31, SNRPE, PCBP1, SF3B1, PRPF8, EIF4A3, RBMX, DDX46, U2SURP, CRNKL1, LSM7, EFTUD2, HNRNPK, DDX5, RBM17, SRSF10, PRPF6, SRSF8, XAB2, SNRPB, CDC40, SF3A2, SNRNP200, HSPA8, SF3A1, SRSF2, LSM2, U2AF1, LSM6, DHX8, SNRNP70, SART1, LSM4, DDX42, TCERG1, DDX39B, SRSF7, TXNL4A, ACIN1, SRSF1, AQR, ALYREF, PQBP1, ISY1, DHX15, TRA2B, CCDC12, USP39, PRPF19, U2AF2, SF3B3, SF3B5, PRPF40B, SNRPG, SF3B4, WBP11, SF3B2, LSM8, MAGOHB, LSM3, PPIH, ZMAT2, PHF5A, SF3A3, BCAS2, HNRNPA1, SNRNP40, PRPF18, PRPF38A, THOC3, RBM8A, PPIE, SNU13, CWC15, HNRNPC, SNRPC, SNRNP27, SYF2, DDX23, HSPA1L, PUF60, SLU7, SNRPF, TRA2A, SRSF3, HNRNPA3, SRSF4, PRPF38B, SRSF9",0.97061622231479,0.416801226031377,FALSE
+"H1975","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.50195,1.51,0.0617,2472,0.905,"PGM2L1, PYGL, PYGB, ENPP1, GBE1, UGDH, HK2, GPI, PGM2, MGAM, HK3",1.20971483596676,0.0433514207947967,FALSE
+"H1975","Input","KEGG_STEROID_BIOSYNTHESIS",-0.55301,-1.71,0.0458,8363,0.315,"SQLE, SOAT2, CYP27B1, DHCR24, MSMO1, FDFT1, HSD17B7, DHCR7, CYP51A1, TM7SF2",1.33913452199613,0.501689446210399,FALSE
+"H1975","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.44592,-1.35,0.126,9071,0.426,"HSD17B7, AKR1D1, AKR1C3, AKR1C1, HSD11B2, HSD17B2",0.899629454882437,0.370590400897281,FALSE
+"H1975","Input","KEGG_SULFUR_METABOLISM",-0.47961,-1.47,0.0816,9330,0.381,"SUOX, SULT1A1",1.08830984124614,0.419075024324381,FALSE
+"H1975","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.4798,1.43,0.114,1782,0.704,"C4A, CD40, ACTN3, C3, ACTN1, C1R, TRIM21",0.943095148663527,0.152427340857888,FALSE
+"H1975","Input","KEGG_TASTE_TRANSDUCTION",0.42289,1.3,0.154,209,0.63,"PRKACA, CACNA1A",0.812479279163537,0.200659450546418,FALSE
+"H1975","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.54759,-1.68,0.0622,7326,0.283,"PDSS1, MVK, HMGCS1, ACAT2, IDI1, DHDDS, HMGCR",1.20620961530918,0.54821356447571,FALSE
+"H1975","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.30038,0.903,0.552,2687,0.653,"THBS2, MYC, AMH, THBS1, SMURF1, RPS6KB2, RBL2, ZFYVE16, E2F4, MAPK1, PPP2CB, SMAD4, TGFBR1, ACVR1, E2F5, SMAD1, SMURF2, TGFB2",0.258060922270801,0.185086818724926,FALSE
+"H1975","Input","KEGG_THYROID_CANCER",0.42462,1.27,0.177,3100,0.58,"TP53, MYC, PPARG, MAP2K2, NCOA4, MAPK1, TCF7L1, BRAF, RXRG, PAX8, TPM3, CCND1, CTNNB1, CDH1, TFG",0.752026733638193,0.236572006437063,FALSE
+"H1975","Input","KEGG_TIGHT_JUNCTION",0.32384,0.979,0.446,1251,0.595,"MYH7, PRKCA, MYH11, MYL9, MYH9, PTEN, AKT1, PRKCH, LLGL1, CLDN4, ACTN3, RRAS2, MYL12A, MYH10, EPB41L2, PRKCB, GNAI2, CASK, PRKCD, CLDN16, CLDN6, EPB41L1, TJP2",0.350665141287858,0.22548303427145,FALSE
+"H1975","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.3736,1.13,0.268,2278,0.601,"LY96, IRF5, CD40, AKT1, CASP8, MAP2K2, PIK3R2, IRAK4, TAB1, MAPK10, IRAK1, MYD88, MAPK8, IRF7, MAP2K4, CD14, PIK3CA, MAP3K7, IKBKG, TOLLIP, MAPK1, CHUK, IKBKB, TAB2, FADD, NFKB1, LBP",0.571865205971211,0.22112552799726,FALSE
+"H1975","Input","KEGG_TRYPTOPHAN_METABOLISM",0.40515,1.21,0.217,1308,0.581,"MAOB, CYP1B1, KYNU, GCDH, EHHADH, MAOA",0.66354026615147,0.235823867609669,FALSE
+"H1975","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.45913,1.38,0.112,2992,0.68,"CACNA1A, PIK3R2, MAPK10, PRKCD, MAPK8, PIK3CA, PKM, MAPK1, IRS1, IKBKB, HK2, IRS2, HK3, ABCC8, PKLR, MTOR, INSR, MAPK9",0.950781977329818,0.167491087293764,FALSE
+"H1975","Input","KEGG_TYROSINE_METABOLISM",0.45094,1.35,0.135,1308,0.722,"ALDH3B1, MAOB, TAT, MIF, GSTZ1, TRMT11, MAOA",0.869666231504994,0.141462802430361,FALSE
+"H1975","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.35193,1.05,0.359,3051,0.59,"PAK5, PAK6, CARD11, VAV2, VAV1, AKT1, MALT1, MAP2K2, RAF1, PIK3R2, PIK3CA, MAP3K7, IKBKG, PAK1, FYN, PPP3CA, MAPK1, CHUK, IKBKB, PPP3CB, CDK4, PDPK1, NFKB1, PAK3, NFATC3, CBL, SOS2, PAK2, MAPK14, BCL10, MAPK9, NFAT5",0.444905551421681,0.229147988357856,FALSE
+"H1975","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.21391,0.648,0.891,1755,0.974,"UBA7, ITCH, UBE2O, CUL4B, UBE3C, HUWE1, UBA6, CUL7, KEAP1, MGRN1, SMURF1, FBXW11, HERC1, UBE2M, HERC4, WWP2, STUB1, UBA1, ERCC8, BIRC6, FBXW8, XIAP",0.0501222959631252,0.0114410431213845,FALSE
+"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.25119,-0.756,0.752,8873,0.859,"BCAT1",0.123782159408358,0.0660068361687577,FALSE
+"H1975","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.42544,-1.3,0.152,7467,0.433,"ACADM, ALDH6A1, ALDH7A1, HADH, HADHA, ACADS, OXCT1, ABAT, ALDH3A2, HMGCS1, ACAT2, HIBCH, BCAT1, ALDH2, DBT, AUH, MCEE",0.818156412055227,0.363512103646635,FALSE
+"H1975","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.43447,1.28,0.168,1381,0.613,"CALD1, MYLK, PLA2G6, PRKACA, PRKCA, MYH11, MYL9, ITPR1, PRKCH, ARAF, ADCY7, GNA13, MYL6, PRKCB, MAP2K2, RAF1, GNA11, GNA12, PRKCD, MYL6B, CACNA1F",0.774690718274137,0.212539525481585,FALSE
+"H1975","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.41656,1.27,0.167,2604,0.58,"PRKACA, DYNC1I2, DYNC1H1, DYNC1LI2, DCTN1, DYNC1LI1, DYNC2LI1, CREB5, DCTN2, RAB5B, DCTN4, DCTN5, DYNC2H1, PRKACB, GNAS, STX4, RAB5A",0.777283528852417,0.236572006437063,FALSE
+"H1975","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.43332,1.33,0.156,1074,0.654,"NOS3, RAC2, PLA2G6, PRKCA, HSPB1, AKT1, PRKCB, MAP2K2, PLCG2, RAF1, PIK3R2, MAPKAPK3",0.806875401645538,0.184422251675733,FALSE
+"H1975","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.34744,1.06,0.358,2785,0.606,"PRKACA, PRKCA, KDELR1, PRKCB, PLCG2, TJP2, PRKACB, ATP6V1C1, ATP6V1G1, GNAS, ATP6V1D, ATP6V1E1, ATP6V1B2, TCIRG1",0.446116973356126,0.217527375833714,FALSE
+"H1975","Input","KEGG_VIRAL_MYOCARDITIS",0.47521,1.45,0.0847,825,0.698,"MYH7, RAC2, CAV1, MYH11, MYH9, ICAM1, CD40, CASP8, MYH10",1.07211658966929,0.156144577376839,FALSE
+"H1975","Input","KEGG_WNT_SIGNALING_PATHWAY",0.32988,1.02,0.395,2201,0.588,"RAC2, FZD2, TP53, PRKACA, PRKCA, PRICKLE1, MYC, WNT5B, DVL1, PRKCB, DVL2, FBXW11, MAPK10, PPP2R5E, MAPK8, DAAM1, MAP3K7, PPP2R5B, PPP3CA, PPP2CB, PPP3CB, APC, SMAD4, PRKACB, TCF7L1, PPP2R5C",0.40340290437354,0.230622673923862,FALSE
+"H2009","Input","KEGG_ABC_TRANSPORTERS",0.32322,1.08,0.3,1760,0.502,"ABCG2, ABCD1, ABCC1, ABCA1, ABCC3",0.522878745280338,0.299296282854981,FALSE
+"H2009","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.46475,-1.51,0.0702,7134,0.356,"RPS6KB1, MTOR, PIK3CB, MAP2K2, IKBKG, STAT5A, NFKB1, SOS1, RPS6KB2, PIK3R2, MAPK1, ARAF, RELA, AKT1, BRAF, MAPK3, PIK3CA, PIK3R1, AKT2, CEBPA, IKBKB, EIF4EBP1, RAF1, CCND1",1.15366288787019,0.448550002027125,FALSE
+"H2009","Input","KEGG_ADHERENS_JUNCTION",0.26174,0.872,0.59,1714,0.673,"RAC2, CTNNB1, CDH1, CTNND1, CTNNA1, CTNNA2, LMO7, NECTIN4, TJP1, NECTIN1, ACTN4, BAIAP2, MET, AFDN, SSX2IP, ERBB2, IGF1R, SORBS1, PTPRJ, YES1, NECTIN2",0.229147988357856,0.171984935776023,FALSE
+"H2009","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.49211,-1.55,0.0782,6982,0.355,"ACSL5, MAPK10, ACACB, MTOR, NFKBIB, IKBKG, PRKCQ, NFKB1, STK11, PRKAG2, TRAF2, PRKAB2, CPT1A, PCK2, MAPK8, PRKAB1, NFKBIE, RELA, AKT1, CAMKK2, PTPN11, PRKAA1, AKT2, PRKAG1, IKBKB",1.10679324694015,0.449771646944906,FALSE
+"H2009","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.41557,-1.33,0.132,8405,0.351,"CAD, ADSL, ASL, NIT2, ASNS, CPS1, ASS1",0.87942606879415,0.454692883534176,FALSE
+"H2009","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.24436,-0.792,0.713,6160,0.808,"IRS2, INSR, PRKCA, HSD11B2, PRKCB, PIK3CB, PIK3R2, MAPK1, NEDD4L, MAPK3, PIK3CA, PIK3R1",0.146910470148134,0.0925886392254138,FALSE
+"H2009","Input","KEGG_ALZHEIMERS_DISEASE",-0.1856,-0.595,0.958,6977,0.975,"CDK5, ATP5PB, CAPN2, NDUFAB1, CASP9, COX6C, CASP8, CASP3, MAPK1, BACE2, ATP2A3, APAF1, IDE, FADD, GAPDH, APBB1, MAPK3, MME, CAPN1, GSK3B, PLCB4, CASP7, PLCB2",0.0186344909214556,0.0109953843014632,FALSE
+"H2009","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.23689,-0.777,0.722,5956,0.827,"NARS2, FARS2, SARS2, EARS2, WARS2, MTFMT, FARSB, VARS2, FARSA, SEPSECS",0.141462802430361,0.0824944904474534,FALSE
+"H2009","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.6384,-2.06,0.0102,6681,0.349,"NANS, GFPT2, GMPPA, UGP2, GCK, CYB5R1, GNE, HK3, NAGK, GALE, PGM2, GALK1, PGM1, GFPT1, GALK2, PMM2, GMDS, MPI, PGM3, PMM1, GNPDA2, GMPPB, GALT, UAP1, FPGT, GNPNAT1, GNPDA1, GPI, AMDHD2",1.99139982823808,0.45717457304082,FALSE
+"H2009","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.25587,-0.838,0.603,7014,0.766,"CCS, CASP9, MAPK14, MAPK12, CASP1, CASP3, NEFM, PRPH, PRPH2, APAF1, BAX, SOD1, MAP2K3",0.219682687859849,0.115771230367396,FALSE
+"H2009","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.2992,0.967,0.473,2758,0.554,"CTSS, CTSL, CD74, RFXAP, RFXANK, CTSB, CALR, HSPA5, CREB1, RFX5, TAPBP, PSME3, NFYB, HSPA1L, IFI30, PDIA3",0.325138859262188,0.25649023527157,FALSE
+"H2009","Input","KEGG_APOPTOSIS",-0.33497,-1.08,0.331,7026,0.471,"CAPN2, IRAK4, PIK3CB, CASP9, CASP6, IKBKG, NFKB1, BIRC2, CASP8, CASP3, TRAF2, PIK3R2, APAF1, IL1A, MYD88, RIPK1, BAX, RELA, AKT1, FADD, DFFB, PIK3CA, CAPN1, PIK3R1, AKT2, CASP7, IKBKB",0.480172006224281,0.326979092871104,FALSE
+"H2009","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.31385,1.03,0.365,356,0.526,"GPX1, PLA2G12A, GGT5",0.437707135543525,0.279014255846261,FALSE
+"H2009","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.25409,0.852,0.626,575,0.698,"GLUD2, GATM, ARG1, ALDH1B1, OAT, MAOA, PYCR1",0.20342566678957,0.156144577376839,FALSE
+"H2009","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.7275,2.42,0,765,0.14,"ITGB6, ITGB4, ITGA2B, DSC2, GJA1, ITGA6, DSG2, PKP2, ITGA3, CTNNB1, LMNA, ITGA4, ITGB8, CTNNA1, CTNNA2, ITGA5, ITGA2, ITGAV, ACTN4",Inf,0.853871964321762,TRUE
+"H2009","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56676,1.79,0.0212,2597,0.19,"ALDH1B1, ALDH2, UGDH, ALDH7A1, ALDH3A2",1.67366413907125,0.721246399047171,TRUE
+"H2009","Input","KEGG_AXON_GUIDANCE",0.23453,0.778,0.732,1058,0.77,"RAC2, SEMA4B, EFNB2, EPHA1, SEMA4D, EPHA2, HRAS, ROBO1, EPHB2, KRAS, NRAS, MET, PLXNB2, SEMA7A",0.135488918941608,0.113509274827518,FALSE
+"H2009","Input","KEGG_BASAL_CELL_CARCINOMA",0.32696,1.05,0.354,2067,0.527,"TP53, CTNNB1, FZD6, DVL1, WNT5B, FZD7, APC",0.450996737974212,0.278189384787453,FALSE
+"H2009","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.15908,0.518,0.99,6214,1,"TAF12, GTF2H1, TAF4, TAF11, TAF5, GTF2I, GTF2B, GTF2H2, TAF5L, TAF6, TAF9, TAF10, GTF2F2, TAF1, GTF2H3, TAF2, GTF2E2, GTF2H4, GTF2F1, TAF7, TAF6L, GTF2E1, GTF2A2, TAF9B, TBP, GTF2A1",0.00436480540245009,0,FALSE
+"H2009","Input","KEGG_BASE_EXCISION_REPAIR",-0.25731,-0.836,0.637,5421,0.761,"POLE4, UNG, PARP1, POLE2, POLL, MUTYH, POLE, FEN1, PARP4, MPG, NTHL1, NEIL2, SMUG1, HMGB1, APEX1",0.19586056766465,0.118615343229427,FALSE
+"H2009","Input","KEGG_BETA_ALANINE_METABOLISM",0.40571,1.33,0.145,2236,0.341,"ACADM, ALDH1B1, ECHS1, HADHA, ALDH2, SMS, ALDH7A1",0.838631997765025,0.467245621007502,FALSE
+"H2009","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.46174,1.5,0.0995,1789,0.246,"FADS2, ACAA1, ACOX1, PECR, HADHA, ELOVL6, ELOVL5, FADS1",1.00217691925427,0.609064892896621,FALSE
+"H2009","Input","KEGG_BLADDER_CANCER",0.33547,1.1,0.31,1410,0.495,"TP53, MMP1, CDH1, VEGFA, CDKN2A, HRAS, KRAS, NRAS, CXCL8, ERBB2, VEGFC, MYC",0.508638306165727,0.305394801066431,FALSE
+"H2009","Input","KEGG_BUTANOATE_METABOLISM",0.44758,1.46,0.0853,2315,0.267,"ALDH1B1, OXCT1, ACAT1, ECHS1, HADH, HADHA, PDHA1, PDHB, ALDH2, ALDH7A1, HMGCL",1.06905096883248,0.573488738635425,FALSE
+"H2009","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.34974,-1.11,0.314,6569,0.468,"BTK, BCL10, VAV3, PPP3CC, PTPN6, PIK3AP1, MAP2K1, PRKCB, PIK3CB, NFKBIB, PLCG2, MAP2K2, IKBKG, NFKB1, SOS1, NFATC2, PIK3R2, MAPK1, VAV2, NFKBIE, RELA, AKT1, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, MALT1, IKBKB, RAF1",0.503070351926785,0.329754146925876,FALSE
+"H2009","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.19421,-0.628,0.934,7972,0.964,"PHKG2, ATP2A3, PHKB, SLC8A1, PDGFRA, PDGFRB, PPID, P2RX4, PLCG1, PLCB4, PLCB2",0.0296531237699066,0.0159229660971692,FALSE
+"H2009","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.34627,1.16,0.241,1871,0.443,"TNNC1, ATP1A2, SLC9A6, ATP1B1, SLC9A1, UQCRH, CACNA2D1, UQCRB, UQCRFS1",0.617982957425132,0.35359627377693,FALSE
+"H2009","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.57772,1.89,0.022,843,0.197,"CDH15, CDH3, CNTN1, ITGB2, CD274, CLDN7, ITGA6, F11R, SDC4, ALCAM, CDH1, ITGA4, ITGB8, NLGN2, CD276, ITGAV, CD58, CD99, NECTIN1, ICAM2, PVR, ICAM1",1.65757731917779,0.705533773838407,TRUE
+"H2009","Input","KEGG_CELL_CYCLE",-0.22933,-0.736,0.786,7610,0.853,"CCND3, TFDP2, CDK1, ABL1, YWHAQ, YWHAG, BUB1B, CDKN1A, SMAD2, TGFB3, ORC6, CDK6, GSK3B, PTTG1, CDKN1B, CDKN2C, CCND1, RB1",0.104577453960592,0.069050968832477,FALSE
+"H2009","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.4488,-1.41,0.121,7050,0.359,"PRKCB, ROCK1, PXN, PIK3CB, NFKBIB, PTK2B, IKBKG, CRKL, NFKB1, SOS1, GNAI1, PTK2, PIK3R2, MAPK1, VAV2, GSK3A, CRK, ROCK2, FOXO3, PRKCZ, ADCY5, RELA, PREX1, AKT1, BRAF, GRK2, MAPK3, ADCY6, PIK3CA, CCL13, CCL20, GSK3B, PIK3R1, AKT2, PLCB4, STAT2, IKBKB, ELMO1, CSK, PLCB2, RAF1, CXCR4, WAS",0.91721462968355,0.444905551421681,FALSE
+"H2009","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.44086,-1.4,0.116,7329,0.362,"MAP2K2, IKBKG, CRKL, STAT5A, NFKB1, SOS1, ABL1, PIK3R2, MAPK1, CRK, ARAF, CDKN1A, RELA, CBL, AKT1, BRAF, TGFB3, MAPK3, PTPN11, PIK3CA, CDK6, PIK3R1, AKT2, CBLB, IKBKB, CDKN1B, GAB2, RAF1, CCND1, RB1",0.935542010773082,0.441291429466834,FALSE
+"H2009","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.65024,2.16,0.00714,1274,0.173,"BHLHE41, BHLHE40, CLOCK",2.14630178822383,0.761953896871205,TRUE
+"H2009","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.30027,0.987,0.407,3184,0.532,"SDHA, SDHB, IDH3A, PDHA1, PDHB, SUCLG2, SUCLG1, DLST, MDH2, ACO2, IDH3G, FH, PC, DLD, IDH3B, SDHD",0.39040559077478,0.274088367704952,FALSE
+"H2009","Input","KEGG_COLORECTAL_CANCER",-0.29448,-0.948,0.471,6980,0.615,"MAP2K1, APPL1, MAPK10, PIK3CB, CASP9, CASP3, PIK3R2, MAPK1, MAPK8, ARAF, SMAD2, BAX, AKT1, BRAF, TGFB3, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, RAF1, CCND1",0.326979092871104,0.211124884224583,FALSE
+"H2009","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.56122,1.83,0.0287,587,0.18,"PLAT, F3, SERPINA1, PLAU, THBD, MBL2, CFI, PLAUR, TFPI, CD55, PROS1",1.54211810326601,0.744727494896694,TRUE
+"H2009","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.42514,-1.35,0.14,6006,0.353,"AHCYL1, AHCYL2, LDHB, TAT, MPST, MAT2A, CTH, ADI1, MTR, MAT1A, ENOPH1, SDS, LDHA, AHCY, CDO1, CBS, SRM",0.853871964321762,0.452225294612177,FALSE
+"H2009","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.28406,0.91,0.564,2322,0.619,"LIFR, OSMR, TNFRSF1A, VEGFA, TNFSF9, IL13RA1, EPO, IL1R1, LTBR, MET, IL1RAP, TGFB2, CXCL8, VEGFC, TNFRSF10B, PDGFC, TNFRSF12A, TNFRSF10A, ACVR1, TNFSF13B, IL10RB, IL25, CD40",0.248720896016658,0.208309350979882,FALSE
+"H2009","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.38272,-1.22,0.222,7218,0.41,"NFKBIB, IKBKG, NFKB1, CASP1, IRF3, IL18, DDX58, RIPK1, TBK1, RELA, PYCARD, IKBKB",0.653647025549361,0.387216143280265,FALSE
+"H2009","Input","KEGG_DILATED_CARDIOMYOPATHY",0.53846,1.76,0.0502,1330,0.196,"ITGB6, TNNC1, ITGB4, ITGA2B, ITGA6, ITGA3, LMNA, ITGA4, ITGB8, ITGA5, ITGA2, ITGAV, TTN, SGCB, TGFB2, CACNA2D1, DAG1",1.29929628285498,0.707743928643524,FALSE
+"H2009","Input","KEGG_DNA_REPLICATION",0.30351,1,0.389,3899,0.541,"POLA2, MCM3, POLD4, RFC4, SSBP1, RFC1, RFC2, RNASEH2A, RPA3, MCM4, RFC3, RFC5, MCM7, POLD3, MCM2, POLE3, POLA1, PRIM2, RPA2, PCNA, MCM6, POLD2, MCM5, RPA1, LIG1",0.410050398674292,0.266802734893431,FALSE
+"H2009","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.3217,1.06,0.346,866,0.522,"NOTCH3, ETV6, KRAS",0.460923901207223,0.282329496997738,FALSE
+"H2009","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.43435,-1.41,0.107,8535,0.359,"ALDH3A1, GSTZ1, GSTO1, GSTP1, GSTM3, ADH5",0.97061622231479,0.444905551421681,FALSE
+"H2009","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.42153,-1.33,0.14,6255,0.351,"GUSB, UCK2, UCK1, TK1, TK2, IMPDH1, GMPS, UPP1, NAT1, DPYD, XDH, HPRT1, IMPDH2, UMPS, TPMT, ITPA",0.853871964321762,0.454692883534176,FALSE
+"H2009","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.64879,2.14,0.00481,772,0.142,"ITGB6, LAMC2, COL6A1, TNC, ITGB4, ITGA2B, LAMB3, ITGA6, ITGA3, SDC4, ITGA4, ITGB8, LAMA3, LAMA4, ITGA5, ITGA2, LAMB1, ITGAV, COL6A6, CD47",2.31785492362617,0.847711655616944,TRUE
+"H2009","Input","KEGG_ENDOCYTOSIS",-0.37891,-1.21,0.236,6772,0.415,"EHD4, SMAP2, VPS37C, SH3GLB2, PARD6G, CLTC, SH3GLB1, PARD6B, CHMP6, F2R, VPS36, RABEP1, ASAP1, DNM3, VPS4A, EHD2, MVB12A, PDCD6IP, ASAP2, VTA1, DNM2, SH3GL1, USP8, CHMP4A, CHMP4B, VPS28, LDLRAP1, PRKCZ, NEDD4L, VPS37A, VPS4B, ACAP2, PDGFRA, TSG101, NEDD4, CBL, SNF8, PRKCI, ARFGAP2, EHD1, SMAP1, GRK2, FGFR2, CHMP5, IQSEC1, EHD3, TRAF6, CHMP2A, VPS25, ARAP2, CBLB, ARAP1, ACAP3, CXCR4, ARFGAP1, ARFGAP3",0.627087997029893,0.381951903287907,FALSE
+"H2009","Input","KEGG_ENDOMETRIAL_CANCER",-0.30712,-1,0.399,7206,0.573,"PIK3CB, CASP9, MAP2K2, SOS1, PTEN, PIK3R2, MAPK1, FOXO3, ARAF, AKT1, BRAF, ILK, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, RAF1, CCND1",0.399027104313252,0.24184537803261,FALSE
+"H2009","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.35331,-1.12,0.293,7031,0.467,"MAPK10, ATP6V1E1, ATP6V1G1, PLCG2, IKBKG, NFKB1, MAPK14, MAPK12, CASP3, ATP6V1H, MAPK8, MAP2K4, ATP6V1B2, ATP6V1B1, ATP6V1A, ATP6V1C1, RELA, PTPN11, JAM3, PLCG1, IKBKB, CSK",0.533132379645891,0.330683119433888,FALSE
+"H2009","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.41731,-1.33,0.129,6980,0.351,"MAP2K1, PAK3, MAPK10, PRKCB, RPS6KB1, MTOR, CAMK2B, PIK3CB, PAK2, PLCG2, MAP2K2, NCK1, CRKL, STAT5A, SOS1, RPS6KB2, MAP2K7, PTK2, ABL1, PIK3R2, MAPK1, MAPK8, MAP2K4, CRK, ARAF, CDKN1A, CBL, AKT1, BRAF, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, PLCG1, CBLB, CDKN1B, EIF4EBP1, RAF1",0.889410289700751,0.454692883534176,FALSE
+"H2009","Input","KEGG_ETHER_LIPID_METABOLISM",0.58448,1.94,0.0169,795,0.219,"LPCAT1, PLPP2, PLA2G12A, CHPT1, PLPP3, LPCAT2, AGPS",1.77211329538633,0.659555885159882,TRUE
+"H2009","Input","KEGG_FATTY_ACID_METABOLISM",0.49933,1.66,0.0542,1776,0.207,"ACADM, ALDH1B1, ACAA1, ACOX1, ACADVL, CPT2, ACAT1, ECHS1, HADHB, HADH, HADHA, ACSL4, ACADSB, ECI2, ACSL3, ALDH2",1.26600071346161,0.684029654543082,FALSE
+"H2009","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34406,-1.1,0.318,6980,0.449,"MAP2K1, MAPK10, PRKCB, PIK3CB, PLCG2, MAP2K2, MAPK14, MAPK12, SOS1, MAP2K7, PIK3R2, MAPK1, VAV2, MAPK8, MAP2K4, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, MAP2K3, GAB2, RAF1",0.497572880015567,0.347753658996677,FALSE
+"H2009","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.33471,-1.1,0.301,6267,0.449,"ARPC2, PRKCA, PAK1, ARPC4, DNM1L, PIP4K2B, ARPC1A, VAV3, CFL1, WASL, MAP2K1, PRKCB, RPS6KB1, PIK3CB, PLCG2, AMPH, CRKL, ASAP1, LIMK2, DNM3, RPS6KB2, ASAP2, DNM2, PIK3R2, MAPK1, VAV2, CRK, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, GAB2, RAF1, WAS",0.521433504406157,0.347753658996677,FALSE
+"H2009","Input","KEGG_FOCAL_ADHESION",0.33848,1.13,0.265,765,0.474,"ITGB6, LAMC2, RAC2, COL6A1, TNC, ITGB4, ITGA2B, LAMB3, ITGA6, ITGA3, CAV2, CTNNB1, VEGFA, ITGA4, ITGB8, LAMA3, LAMA4, PIK3R3, ITGA5, FLNB, ITGA2, HRAS, LAMB1, ITGAV, COL6A6, JUN, ACTN4",0.576754126063192,0.324221658325915,FALSE
+"H2009","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.54975,-1.79,0.0322,5955,0.414,"QDPR, PTS, SPR, DHFR",1.49214412830417,0.382999658879101,FALSE
+"H2009","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.52604,-1.71,0.0414,7189,0.372,"HK3, TPI1, ALDOA, SORD, KHK, PMM2, GMDS, MPI, PMM1, PHPT1, PFKFB3, GMPPB, PFKP, MTMR2, MTMR6, FPGT, PFKM, PFKL",1.3829996588791,0.429457060118102,FALSE
+"H2009","Input","KEGG_GALACTOSE_METABOLISM",-0.48625,-1.53,0.0747,6911,0.348,"UGP2, GCK, HK3, GALE, PGM2, GALK1, PGM1, GALK2, PFKP, GALT, PFKM, PFKL",1.1266793981846,0.458420756053419,FALSE
+"H2009","Input","KEGG_GAP_JUNCTION",-0.45665,-1.49,0.0799,7537,0.366,"SOS1, GNAI1, CDK1, TUBB4B, MAPK1, MAPK7, ADCY5, PDGFRA, PDGFRB, TUBA1C, TUBB1, TUBB3, MAP2K5, MAPK3, TUBB, TUBB6, ADCY6, TUBA3C, TUBA1B, TUBB2A, TUBAL3, PLCB4, PLCB2, RAF1, TUBB2B",1.09745322068601,0.436518914605589,FALSE
+"H2009","Input","KEGG_GLIOMA",-0.39128,-1.25,0.205,6980,0.409,"MAP2K1, PRKCB, MTOR, CAMK2B, PIK3CB, PLCG2, MAP2K2, SOS1, PTEN, PIK3R2, MAPK1, ARAF, CDKN1A, PDGFRA, PDGFRB, AKT1, BRAF, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, PLCG1, RAF1, CCND1, RB1",0.688246138944246,0.388276691992658,FALSE
+"H2009","Input","KEGG_GLUTATHIONE_METABOLISM",-0.44793,-1.45,0.0938,8007,0.373,"RRM2B, GCLC, OPLAH, PGD, GGCT, GSTZ1, GSTO1, GSTP1, RRM2, GSTM3, SRM, LAP3, RRM1",1.02779716162094,0.428291168191312,FALSE
+"H2009","Input","KEGG_GLYCEROLIPID_METABOLISM",0.30294,0.961,0.457,483,0.553,"ALDH1B1, PLPP2, DGKE, PLPP3, GPAT3, GLA",0.34008379993015,0.257274868695302,FALSE
+"H2009","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32367,1.1,0.275,380,0.495,"PEMT, LPCAT1, PLPP2, DGKE, PLA2G12A, CHPT1, PLPP3, GPAT3",0.560667306169737,0.305394801066431,FALSE
+"H2009","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.36317,1.2,0.215,713,0.423,"PIPOX, GATM, MAOA, BHMT",0.667561540084395,0.373659632624958,FALSE
+"H2009","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.44311,-1.39,0.12,6930,0.344,"GCK, BPGM, PKM, HK3, TPI1, PGM2, ALDOA, PGM1, ENO1, LDHA, PCK2, PGAM1, PGAM4, ENO3, PKLR, ACSS2, PGK1, GAPDH, ALDH3A1, PFKP, GPI, PFKM, AKR1A1, ADH5, PFKL",0.920818753952375,0.46344155742847,FALSE
+"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.3152,1.04,0.309,2826,0.532,"CHST11, CHST3, CHST12, XYLT2, DSE, CHST7",0.510041520575165,0.274088367704952,FALSE
+"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.4217,1.4,0.116,2292,0.3,"HS6ST1, EXTL2, HS6ST2, XYLT2",0.935542010773082,0.522878745280338,FALSE
+"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.40924,1.36,0.13,455,0.319,"B4GALT3, B4GALT1",0.886056647693163,0.496209316942819,FALSE
+"H2009","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.25099,-0.799,0.681,8293,0.804,"HGSNAT, HYAL1",0.166852888087215,0.0947439512515487,FALSE
+"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.77325,-2.51,0,8777,0.0853,"ST3GAL2, B4GALNT1",Inf,1.06905096883248,TRUE
+"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.5863,1.94,0.0185,483,0.219,"B3GALNT1, GLA",1.73282827159699,0.659555885159882,TRUE
+"H2009","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.67762,2.27,0.00455,944,0.154,"B3GNT3, B4GALT3, B4GALT1, ST3GAL4",2.34198860334289,0.812479279163537,TRUE
+"H2009","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.51447,-1.66,0.0385,5557,0.334,"PIGT, PIGK, GPAA1, PIGO, PIGH, PIGM, PIGQ, PIGU",1.4145392704915,0.476253533188435,FALSE
+"H2009","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.36586,-1.18,0.229,6932,0.434,"PGP, GRHPR, MDH1, HYI, ACO1, MTHFD1",0.640164517660112,0.362510270487489,FALSE
+"H2009","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.37235,-1.18,0.227,5995,0.434,"ITPR2, CDC42, PRKCD, GNAS, PRKACA, PRKCA, MAP3K3, MAPK9, MAP3K2, ATF4, PLCB3, MAP2K1, MAPK10, PRKCB, CAMK2B, PTK2B, MAP2K2, MAPK14, MAPK12, SOS1, MAP2K7, MAPK1, MAPK8, MAP2K4, MAPK7, MAP3K4, ADCY5, MAPK3, ADCY6, PLCB4, MAP2K3, PLCB2, RAF1",0.643974142806877,0.362510270487489,FALSE
+"H2009","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.4298,-1.36,0.144,8848,0.351,"GSK3B, GLI3",0.84163750790475,0.454692883534176,FALSE
+"H2009","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.56575,1.86,0.0248,819,0.197,"ITGA2B, ITGA6, ITGA3, ITGA4, CD55, ITGA5, ITGA2, EPO, IL1R1",1.60554831917378,0.705533773838407,TRUE
+"H2009","Input","KEGG_HISTIDINE_METABOLISM",0.24155,0.797,0.683,473,0.749,"ALDH1B1, HNMT, MAOA",0.165579296318467,0.125518182300534,FALSE
+"H2009","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.35613,1.18,0.244,3718,0.427,"EME1, RAD51, POLD4, SSBP1, MUS81, RPA3, TOP3A, NBN, POLD3, BRCA2, RAD54L, RPA2, TOP3B, POLD2",0.612610173661271,0.369572124974976,FALSE
+"H2009","Input","KEGG_HUNTINGTONS_DISEASE",0.16114,0.537,0.991,2692,1,"TP53, GPX1, SDHA, RCOR1, POLR2D, NDUFA8, POLR2L, UQCRH, SDHB, POLR2I, SIN3A, POLR2K, CREB5, NDUFS6, POLR2G, UQCRB, CREB1, POLR2J, CLTA, UQCRFS1, NDUFA7, POLR2C, NDUFB1, NDUFA2, NDUFV2, POLR2F, TAF4, UQCRC1, DLG4, VDAC1, POLR2E, NDUFS8, IFT57, NDUFS4, NDUFS5, EP300, HIP1, CLTB, NDUFV3, NDUFB10, NDUFB8, VDAC2, GNAQ, AP2A1",0.00392634551472468,0,FALSE
+"H2009","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.48698,1.6,0.0656,1330,0.225,"ITGB6, TNNC1, ITGB4, ITGA2B, ITGA6, ITGA3, LMNA, ITGA4, ITGB8, ITGA5, ITGA2, ITGAV, TTN, SGCB, TGFB2, CACNA2D1, DAG1",1.18309616062434,0.647817481888638,FALSE
+"H2009","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.51927,-1.65,0.0543,6581,0.326,"PIP4K2B, PI4KB, CDIPT, INPP4A, PLCB3, IMPA2, PIK3CB, MINPP1, TPI1, PLCG2, INPP5B, PTEN, SYNJ1, PIK3C2B, OCRL, PIK3CA, IMPA1, ITPK1, ISYNA1, INPPL1, PIK3C3, PLCG1, PLCB4, INPP1, PLCB2",1.26520017041115,0.486782399932061,FALSE
+"H2009","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.42533,-1.36,0.128,6930,0.351,"GCK, MAP2K1, MAPK10, PHKA1, TSC1, ACACB, RPS6KB1, RPS6, MTOR, HK3, RAPGEF1, PIK3CB, MAP2K2, CRKL, MKNK2, SOS1, RPS6KB2, PRKAG2, PRKAB2, PIK3R2, MAPK1, PCK2, MAPK8, CRK, PHKG2, PRKAB1, ARAF, PRKCZ, PHKB, MKNK1, GYS1, PKLR, CBL, AKT1, BRAF, PRKCI, MAPK3, PPP1R3D, PRKAA1, PIK3CA, TSC2, GSK3B, PIK3R1, AKT2, PRKAG1, SOCS2, CBLB, IKBKB, FOXO1, EIF4EBP1, RAF1",0.892790030352132,0.454692883534176,FALSE
+"H2009","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.38142,-1.25,0.183,8592,0.409,"ICOSLG, CXCR4",0.737548910269571,0.388276691992658,FALSE
+"H2009","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.34591,-1.11,0.282,8325,0.468,"CBL, AKT1, PTPN11, PIK3CA, PIK3R1, STAT6, AKT2, SOCS2, CBLB, STAT2, PIAS4, CCND1, SPRY4",0.549750891680639,0.329754146925876,FALSE
+"H2009","Input","KEGG_LEISHMANIA_INFECTION",-0.30183,-0.978,0.445,6703,0.587,"STAT1, PTPN6, MAP3K7, PRKCB, IRAK4, C3, NFKBIB, NFKB1, MAPK14, MAPK12, MAPK1, IL1A, MYD88, RELA, TGFB3, MAPK3, TAB2, TRAF6",0.351639989019068,0.231361898752386,FALSE
+"H2009","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.29643,0.995,0.369,958,0.529,"ITGB2, RAC2, CLDN7, F11R, CTNNB1, SIPA1, CTNND1, ITGA4, CTNNA1, CTNNA2, PIK3R3, CD99, ACTN4, ICAM1, PIK3CD",0.43297363384094,0.276544327964814,FALSE
+"H2009","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.37952,1.26,0.18,2597,0.374,"ALDH1B1, ECHS1, HADHA, ALDH2, ALDH7A1, ALDH3A2",0.744727494896694,0.42712839779952,FALSE
+"H2009","Input","KEGG_LONG_TERM_DEPRESSION",-0.27573,-0.881,0.577,6833,0.704,"PLCB3, PPP2CA, MAP2K1, PRKCB, GUCY1A1, MAP2K2, GNAI1, PPP2R1B, MAPK1, GNA12, ARAF, BRAF, MAPK3, PPP2CB, PLCB4, GNA13, PLCB2, RAF1",0.238824186844269,0.152427340857888,FALSE
+"H2009","Input","KEGG_LONG_TERM_POTENTIATION",-0.29808,-0.951,0.467,6292,0.617,"PRKACA, PRKCA, ATF4, PPP3CC, PLCB3, MAP2K1, PRKCB, CAMK2B, MAP2K2, MAPK1, ARAF, BRAF, MAPK3, PLCB4, PLCB2, RAF1",0.330683119433888,0.209714835966758,FALSE
+"H2009","Input","KEGG_LYSINE_DEGRADATION",0.4429,1.45,0.0945,2236,0.265,"PIPOX, ALDH1B1, NSD2, ACAT1, ECHS1, DOT1L, PLOD2, EHMT1, HADH, HADHA, ASH1L, ALDH2, SETD2, AASS, DLST, SUV39H1, ALDH7A1",1.02456819149074,0.576754126063192,FALSE
+"H2009","Input","KEGG_LYSOSOME",-0.20063,-0.631,0.933,7680,0.971,"SMPD1, ATP6V1H, AP3M2, CLN3, MANBA, GALC, AP3B1, AP1M1, HGSNAT, HYAL1, AP3M1, AP3S2, AP4E1, AP4M1, AP3S1, AP3D1, CTSG, CLN5",0.0301183562535,0.0127807700919951,FALSE
+"H2009","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.3404,-1.1,0.302,7329,0.449,"MAP2K2, IKBKG, CRKL, NFKB1, HSPB1, MAPK14, MAPK12, MKNK2, SOS1, MAP2K7, CASP3, MAP4K2, TRAF2, RAPGEF2, NFATC2, MAP3K20, MAPK1, MAPK8, GNA12, MAP2K4, CRK, MAPK7, MAP3K4, IL1A, MKNK1, PDGFRA, MAPKAPK2, RELA, PDGFRB, RASA2, AKT1, BRAF, TGFB3, MAP2K5, MAPK3, FGFR2, PPM1A, DUSP3, MEF2C, NLK, NFKB2, TAB2, STK4, TRAF6, AKT2, STMN1, IKBKB, PPP5C, MAP2K3, FGFR1, RAF1",0.519993057042849,0.347753658996677,FALSE
+"H2009","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.44743,-1.44,0.101,6930,0.371,"GCK, IAPP, PKLR, MNX1",0.995678626217357,0.430626090384954,FALSE
+"H2009","Input","KEGG_MELANOGENESIS",-0.25611,-0.816,0.657,6744,0.78,"MITF, PLCB3, MAP2K1, PRKCB, CAMK2B, DCT, MAP2K2, DVL3, GNAI1, MAPK1, ADCY5, MAPK3, ADCY6, GSK3B, PLCB4, PLCB2, RAF1",0.182434630440219,0.10790539730952,FALSE
+"H2009","Input","KEGG_MELANOMA",-0.3888,-1.23,0.207,7715,0.404,"PTEN, PIK3R2, MAPK1, ARAF, CDKN1A, PDGFRA, PDGFRB, AKT1, BRAF, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, FGFR1, RAF1, CCND1, RB1",0.684029654543082,0.393618634889395,FALSE
+"H2009","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.52225,-1.69,0.0436,7659,0.37,"AKR1C1, AKR1C3, GSTT2, ALDH3A1, GSTZ1, GSTO1, GSTP1, GSTM3, ADH5",1.36051351073141,0.431798275933005,FALSE
+"H2009","Input","KEGG_MISMATCH_REPAIR",0.55276,1.84,0.0209,3899,0.191,"POLD4, RFC4, SSBP1, RFC1, RFC2, MSH6, RPA3, MSH2, RFC3, MLH1, RFC5, PMS2, POLD3, RPA2, PCNA, POLD2, RPA1, LIG1",1.67985371388895,0.718966632752272,TRUE
+"H2009","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.53238,-1.73,0.0325,7054,0.379,"TSC1, RPS6KB1, RPS6, MTOR, PIK3CB, RPS6KB2, STK11, PIK3R2, MAPK1, EIF4B, AKT1, BRAF, MAPK3, PRKAA1, PIK3CA, CAB39L, TSC2, STRADA, PIK3R1, AKT2, EIF4EBP1",1.48811663902113,0.421360790031928,FALSE
+"H2009","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.35859,1.18,0.231,958,0.427,"ITGB2, RAC2, RAET1L, ULBP2, ULBP3, MICA, MICB, PIK3R3, HRAS, ICAM2, ICAM1, KRAS, NRAS, PIK3CD",0.636388020107856,0.369572124974976,FALSE
+"H2009","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.41258,-1.32,0.152,5764,0.348,"HTR2B, NR3C1, F2, PLG, TACR1, CHRNE, PRSS1, F2R, HCRTR1, TSPO, P2RX4, CTSG",0.818156412055227,0.458420756053419,FALSE
+"H2009","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.4355,-1.39,0.138,6980,0.344,"MAP2K1, YWHAE, MAPK10, IRAK4, CAMK2B, RAPGEF1, PIK3CB, NFKBIB, PLCG2, MAP2K2, CRKL, NFKB1, YWHAB, MAPK14, MAPK12, SOS1, MAP2K7, RIPK2, ABL1, PIK3R2, MAPK1, YWHAQ, MAPK8, YWHAG, ARHGDIA, CRK, MAPK7, FOXO3, NFKBIE, MAPKAPK2, BAX, RELA, AKT1, BRAF, NGFR, MAP2K5, MAPK3, PTPN11, PIK3CA, TRAF6, GSK3B, PIK3R1, AKT2, PLCG1, IKBKB, CSK, RAF1",0.860120913598763,0.46344155742847,FALSE
+"H2009","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.34527,-1.1,0.315,6958,0.449,"NT5C3A, NT5C2, NADSYN1, NT5C, PNP, NAMPT, NNMT, NMRK1",0.501689446210399,0.347753658996677,FALSE
+"H2009","Input","KEGG_NITROGEN_METABOLISM",-0.45186,-1.42,0.102,8377,0.371,"CA1, CA12, CA9, ASNS, CPS1, CA8",0.991399828238082,0.430626090384954,FALSE
+"H2009","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.56179,-1.78,0.0241,6749,0.381,"MAP3K7, SUGT1, MAPK10, NFKBIB, IKBKG, TRIP6, NFKB1, MAPK14, BIRC2, MAPK12, CASP8, CASP1, RIPK2, MAPK1, MAPK8, HSP90AB1, CARD6, IL18, HSP90AA1, RELA, PYCARD, MAPK3, CCL13, TAB2, TRAF6, IKBKB",1.61798295742513,0.419075024324381,FALSE
+"H2009","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.257,-0.831,0.64,8909,0.762,"NHEJ1",0.193820026016113,0.1180450286604,FALSE
+"H2009","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.34885,-1.12,0.265,6980,0.467,"MAP2K1, PRKCB, PIK3CB, CASP9, PLCG2, MAP2K2, SOS1, PIK3R2, MAPK1, FOXO3, ARAF, AKT1, BRAF, MAPK3, PIK3CA, CDK6, STK4, PIK3R1, AKT2, PLCG1, RAF1, CCND1, RB1",0.576754126063192,0.330683119433888,FALSE
+"H2009","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.38446,1.26,0.183,2904,0.374,"NOTCH3, DTX2, HES1, CTBP1, JAG1, DVL1, CTBP2, RBPJ, DTX3L, NUMB, EP300, NCOR2, SNW1, CREBBP",0.737548910269571,0.42712839779952,FALSE
+"H2009","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.26599,0.849,0.637,3545,0.693,"ERCC5, ERCC8, GTF2H5, MNAT1, POLD4, RFC4, GTF2H1, RFC1, RFC2, RPA3, RFC3, RFC5, RBX1, RAD23B, POLD3, POLE3, CUL4A, GTF2H2, RPA2, PCNA",0.19586056766465,0.159266765388193,FALSE
+"H2009","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.24801,0.814,0.66,2528,0.732,"B4GALT3, B4GALT1, TUSC3, ALG2, ALG10, ALG10B, MAN2A1, FUT8, MGAT2, MAN1A1, MOGS, MAN2A2",0.180456064458131,0.135488918941608,FALSE
+"H2009","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.42598,-1.37,0.13,6177,0.358,"PRKG1, PRKACA, ARRB2, CAMK2B, CLCA2",0.886056647693163,0.446116973356126,FALSE
+"H2009","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.51467,-1.62,0.0626,8150,0.342,"TYMS, DHFR, ATIC, GART, MTHFD1, MTHFR",1.20342566678957,0.465973893943865,FALSE
+"H2009","Input","KEGG_OOCYTE_MEIOSIS",-0.35419,-1.12,0.312,5425,0.467,"CCNB2, ANAPC4, PRKACB, ANAPC7, PKMYT1, PPP3CB, CDK2, MOS, PPP1CA, CDC25C, CDC23, RPS6KA1, FBXW11, ITPR2, YWHAH, ESPL1, CUL1, PRKACA, YWHAZ, PPP2R1A, MAD2L1, CCNB1, PPP3CC, PPP2CA, MAP2K1, YWHAE, PPP2R5C, CAMK2B, YWHAB, MAPK12, PPP2R1B, CDK1, FBXO5, MAPK1, PPP2R5B, YWHAQ, YWHAG, ADCY5, PPP2R5E, MAPK3, ADCY6, PPP2CB, STAG3, PPP2R5A, PPP2R5D, PTTG1",0.505845405981557,0.330683119433888,FALSE
+"H2009","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.26005,0.826,0.654,301,0.722,"NEU1",0.184422251675733,0.141462802430361,FALSE
+"H2009","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.087514,-0.285,1,5656,1,"ATP6V1G2, NDUFA6, NDUFC2, ATP6V0A1, NDUFB5, NDUFA9, COX7A2, ATP5F1A, NDUFA4, ATP6V0C, NDUFS7, ATP5F1C, ATP6V1C2, ATP6V1D, ATP5PB, ATP6V1E1, ATP6V1G1, NDUFAB1, ATP5MG, COX6C, ATP6V1H, ATP6V1B2, LHPP, ATP6V1B1, ATP6V1A, ATP6V1C1, PPA1",0,0,FALSE
+"H2009","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.52575,1.71,0.0382,373,0.215,"GALNT3, GALNT6, GALNT12, GALNT13, GALNT15, GALNT7",1.41793663708829,0.667561540084395,TRUE
+"H2009","Input","KEGG_P53_SIGNALING_PATHWAY",-0.36936,-1.2,0.207,7610,0.421,"CCND3, CASP8, CASP3, CDK1, PTEN, RRM2B, SIAH1, CDKN1A, APAF1, BAX, SESN2, DDB2, CDK6, TSC2, SERPINE1, RRM2, CCND1",0.684029654543082,0.375717904164332,FALSE
+"H2009","Input","KEGG_PANCREATIC_CANCER",-0.27715,-0.88,0.577,7828,0.697,"PIK3R2, MAPK1, MAPK8, ARAF, SMAD2, RELA, AKT1, BRAF, TGFB3, MAPK3, PIK3CA, CDK6, PIK3R1, AKT2, IKBKB, RAF1, CCND1, RB1",0.238824186844269,0.156767221901991,FALSE
+"H2009","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.62371,-1.96,0.0207,7354,0.33,"PPCDC, PANK2, PANK4, DPYD, PPCS",1.68402965454308,0.481486060122112,FALSE
+"H2009","Input","KEGG_PARKINSONS_DISEASE",0.13281,0.435,1,3435,1,"SDHA, UBE2J1, UBE2G2, NDUFA8, UQCRH, SDHB, HTRA2, NDUFS6, UBE2J2, UQCRB, UQCRFS1, NDUFA7, NDUFB1, NDUFA2, NDUFV2, UQCRC1, VDAC1, NDUFS8, NDUFS4, NDUFS5, NDUFV3, LRRK2, NDUFB10, NDUFB8, VDAC2, NDUFA5, NDUFS1, UQCRC2, NDUFA3, NDUFV1, NDUFA10, NDUFB9, SDHD, COX5A, SLC25A5, COX7A2L, NDUFS3, SNCA, SLC25A4",0,0,FALSE
+"H2009","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.50904,-1.67,0.0425,7773,0.368,"TUBB4B, ABL1, YWHAQ, ROCK2, TUBA1C, TUBB1, TUBB3, TUBB, TUBB6, TUBA3C, TUBA1B, TUBB2A, TUBAL3, TUBB2B, CLDN1, WAS",1.37161106994969,0.434152181326482,FALSE
+"H2009","Input","KEGG_PATHWAYS_IN_CANCER",-0.22836,-0.731,0.8,7329,0.852,"MAP2K2, IKBKG, DVL3, CRKL, STAT5A, NFKB1, BIRC2, HGF, SOS1, PTK2, CASP8, CASP3, TRAF2, PTEN, ABL1, PIK3R2, PIAS2, MAPK1, MAPK8, CRK, HSP90AB1, EGLN1, ARAF, CDKN1A, CUL2, SMAD2, PDGFRA, HSP90AA1, BAX, RELA, PDGFRB, CBL, AKT1, BRAF, FADD, TGFB3, MAPK3, FGFR2, PIK3CA, NFKB2, TFG, CDK6, STK4, TRAF6, GSK3B, PIK3R1, GSTP1, DAPK1, AKT2, PLCG1, CEBPA, CBLB, IKBKB, CDKN1B, FOXO1, PIAS4, FGFR1, COL4A1, RAF1, CCND1, RB1, GLI3",0.0969100130080564,0.0695604052332999,FALSE
+"H2009","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.48909,-1.59,0.0612,5337,0.359,"AKR1B1, UGT2B11, UGT2B4, DCXR, GUSB, UGP2, RPE, XYLB, CRYL1",1.21324857785444,0.444905551421681,FALSE
+"H2009","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.57749,-1.89,0.0158,7160,0.318,"PRPS2, PGM2, ALDOA, RBKS, PGM1, PRPS1, PRPS1L1, RPE, PGLS, DERA, TALDO1, PGD, PFKP, GPI, PFKM, PFKL",1.80134291304558,0.497572880015567,FALSE
+"H2009","Input","KEGG_PEROXISOME",0.30176,1.01,0.395,2320,0.536,"PIPOX, ACAA1, SLC25A17, ACOX1, PEX2, AGPS, PECR, PEX6, ABCD1, PEX26, ACSL4, PEX1, PEX13, ECI2, SCP2, ACSL3, FAR1, CROT, GSTK1, HSD17B4, HACL1, HMGCL, ACOT8",0.40340290437354,0.27083521030723,FALSE
+"H2009","Input","KEGG_PHENYLALANINE_METABOLISM",-0.33871,-1.1,0.301,6402,0.449,"TAT, MAOB, DDC, MIF, PRDX6, NAA80, ALDH3A1",0.521433504406157,0.347753658996677,FALSE
+"H2009","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.44934,-1.46,0.0919,6581,0.374,"PIP4K2B, PI4KB, CDIPT, INPP4A, PLCB3, IMPA2, PRKCB, DGKZ, PIK3CB, DGKA, PLCG2, INPP5B, PTEN, PIK3R2, DGKB, SYNJ1, PIK3C2B, OCRL, PIK3CA, IMPA1, ITPK1, PIK3R1, INPPL1, PIK3C3, PLCG1, PLCB4, INPP1, DGKH, PLCB2",1.03668448861389,0.42712839779952,FALSE
+"H2009","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.29433,-0.925,0.494,7805,0.638,"BLVRB, CP, HMBS, UROD, BLVRA, UROS",0.306273051076353,0.195179321278838,FALSE
+"H2009","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.36098,1.2,0.209,1984,0.423,"FADS2, CYP27A1, ACADM, MMP1, ACAA1, APOA1, ACOX1, CPT2, ACSL4, SORBS1, SLC27A4, SCP2, ACSL3, FABP2, RXRA, APOC3",0.679853713888946,0.373659632624958,FALSE
+"H2009","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45448,1.51,0.0913,2446,0.248,"CYP27A1, SCP2, HSD17B4, AMACR",1.0395292224657,0.605548319173784,FALSE
+"H2009","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.17553,0.583,0.962,933,1,"RFXAP, RFXANK",0.0168249279621871,0,FALSE
+"H2009","Input","KEGG_PRION_DISEASES",-0.48858,-1.57,0.0628,6110,0.364,"PRNP, PRKACA, STIP1, NCAM2, MAP2K1, MAP2K2, C9, MAPK1, IL1A, BAX, MAPK3, SOD1, NCAM1",1.2020403562628,0.438898616350944,FALSE
+"H2009","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.30465,-0.984,0.432,7495,0.592,"MAPK14, MAPK12, GNAI1, CDK1, PIK3R2, MAPK1, MAPK8, HSP90AB1, ARAF, ADCY5, HSP90AA1, AKT1, BRAF, MAPK3, ADCY6, PIK3CA, PIK3R1, AKT2, RAF1",0.364516253185088,0.22767829327708,FALSE
+"H2009","Input","KEGG_PROPANOATE_METABOLISM",0.42598,1.37,0.142,2236,0.32,"ACADM, ALDH1B1, ACSS3, MCEE, ACAT1, ECHS1, HADHA, PCCB, SUCLG2, ALDH2, PCCA, SUCLG1, ALDH7A1",0.847711655616944,0.494850021680094,FALSE
+"H2009","Input","KEGG_PROSTATE_CANCER",-0.41227,-1.32,0.151,7178,0.348,"MTOR, PIK3CB, CASP9, MAP2K2, IKBKG, NFKB1, SOS1, PTEN, PIK3R2, MAPK1, HSP90AB1, ARAF, CDKN1A, PDGFRA, HSP90AA1, RELA, PDGFRB, AKT1, BRAF, MAPK3, FGFR2, PIK3CA, GSK3B, PIK3R1, GSTP1, AKT2, IKBKB, CDKN1B, FOXO1, FGFR1, RAF1, CCND1, RB1",0.821023052706831,0.458420756053419,FALSE
+"H2009","Input","KEGG_PROTEASOME",-0.20163,-0.661,0.898,2341,0.945,"PSMD4, PSME3, PSMB10, PSMB6, PSMC5, PSMB7, PSMC6, PSMC3, PSMC4, PSMA1, PSMC2, PSMD14, PSMA4, PSMB9, PSMB2, PSMB3, PSMB4, PSMC1, PSMA3, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB5, PSMA2, PSME4, PSMD2, PSMD11, PSMD6, PSMD7, PSMD13, PSMD1, PSMD8, SEM1, PSMD12, PSMD3, POMP, PSME1, PSME2, PSMF1",0.0467236633326956,0.0245681914907371,FALSE
+"H2009","Input","KEGG_PROTEIN_EXPORT",-0.23798,-0.755,0.751,5254,0.856,"SEC63, SRP68, SRPRB, SPCS1, OXA1L, SRP14, SEC61B, SEC61A1, SRP19, SRP54, SEC11C",0.124360062995832,0.0675262353228468,FALSE
+"H2009","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.39199,1.29,0.169,1189,0.374,"GLUD2, ATP1A2, ATP1B1, GLS, GLS2",0.772113295386326,0.42712839779952,FALSE
+"H2009","Input","KEGG_PURINE_METABOLISM",-0.29485,-0.941,0.47,6958,0.619,"NT5C3A, GMPS, PKM, PRPS2, NUDT9, GUCY1A1, NT5C2, DCK, GMPR2, PDE5A, PDE2A, NT5C, PAICS, PNP, PRPS1, PRPS1L1, PDE8A, XDH, RRM2B, HPRT1, IMPDH2, ADCY5, PKLR, NME3, ADSL, ADCY6, ATIC, NME1, APRT, NUDT5, GART, ADA, AMPD2, ITPA, RRM2, PFAS, RRM1, NUDT2",0.327902142064283,0.208309350979882,FALSE
+"H2009","Input","KEGG_PYRIMIDINE_METABOLISM",-0.23517,-0.749,0.755,7236,0.84,"NT5C2, DCK, UPP1, NT5C, DPYD, PNP, DUT, CTPS2, RRM2B, TYMS, DCTD, NME3, CAD, UPRT, NME1, UMPS, CTPS1, ITPA, RRM2, RRM1, NUDT2",0.122053048370812,0.0757207139381184,FALSE
+"H2009","Input","KEGG_PYRUVATE_METABOLISM",-0.22973,-0.75,0.759,6465,0.847,"HAGHL, ACSS1, ACACA, GRHPR, PKM, HAGH, ACACB, ACAT2, ACYP1, LDHA, PCK2, MDH1, PKLR, ACSS2",0.11975822410452,0.0721165896692931,FALSE
+"H2009","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.23404,-0.751,0.784,6428,0.854,"ARPC4, ACTG1, ARHGEF6, GIT1, IQGAP1, PIP4K2B, ARPC1A, ITGA1, VAV3, MSN, CFL1, WASL, SSH1, DIAPH1, MAP2K1, ARHGEF7, PAK3, MYH14, ROCK1, PXN, PIK3CB, CYFIP2, F2R, PAK2, MAP2K2, CRKL, LIMK2, IQGAP3, MYH10, SOS1, PTK2, ARHGEF1, MYH9, CYFIP1, PIK3R2, MAPK1, VAV2, GNA12, CRK, ROCK2, ARAF, PDGFRA, ITGB3, PFN1, PDGFRB, BRAF, MAPK3, DIAPH3, FGFR2, VCL, PIK3CA, SSH3, ARHGAP35, PIK3R1, DOCK1, GNA13, CSK, FGFR1, RAF1, WAS",0.105683937315562,0.068542129310995,FALSE
+"H2009","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.62889,-2.03,0.00888,8159,0.302,"ATG7, ATG4B, PRKAA1, PIK3R4, PIK3C3, ATG3",2.0515870342214,0.519993057042849,FALSE
+"H2009","Input","KEGG_RENAL_CELL_CARCINOMA",-0.3157,-1.01,0.391,6980,0.565,"MAP2K1, PAK3, RAPGEF1, PIK3CB, PAK2, MAP2K2, CRKL, HGF, SOS1, PIK3R2, MAPK1, CRK, EGLN1, FLCN, ARAF, CUL2, AKT1, BRAF, TGFB3, MAPK3, PTPN11, PIK3CA, PIK3R1, AKT2, RAF1",0.407823242604133,0.247951552180562,FALSE
+"H2009","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.58364,-1.91,0.0187,8618,0.338,"MME, ACE, CTSG, ACE2",1.7281583934635,0.471083299722345,FALSE
+"H2009","Input","KEGG_RETINOL_METABOLISM",-0.38306,-1.24,0.201,9074,0.414,"ADH5, ALDH1A1",0.696803942579511,0.382999658879101,FALSE
+"H2009","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.35905,-1.14,0.268,6823,0.474,"ACP2, RFK, ACP1, PHPT1, MTMR2, MTMR6",0.571865205971211,0.324221658325915,FALSE
+"H2009","Input","KEGG_RIBOSOME",-0.6532,-2.09,0.00708,6319,0.451,"RPL35, RPLP0, RPS4Y1, RPL23, RPL22L1, RPS15A, RPL23A, RPL36, RPL24, RSL24D1, RPL22, RPS7, RPL3, RPS19, RPL17, RPS8, RPL10, RPL15, RPS6, RPS15, RPL5, RPS4X, RPL7, RPS20, RPL30, RPS17, RPL31, RPS3, RPS24, RPS3A, RPL18A, RPL9, RPL27A, RPS25, RPS26, RPL35A, RPS5, RPL10A, RPL27, RPS13, RPL8, RPL4, RPL37A, RPL18, RPL21, RPL26, RPS2, RPL32, RPL29, RPS16, RPL6, RPL7A, RPL13A, RPL14, RPL28, RPS9, RPL37, RPS10, RPS18, RPL34, UBA52, RPL19, RPS11, FAU, RPS27L, RPS23, RPL36A, RPL36AL, RPL38, RPL26L1",2.14996674231023,0.345823458122039,FALSE
+"H2009","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.55481,-1.75,0.0371,6379,0.385,"ATG5, MAPK9, MAVS, TRAF3, MAP3K7, TRIM25, MAPK10, NFKBIB, DHX58, IKBKG, TBKBP1, NFKB1, MAPK14, MAPK12, CASP8, TANK, TRAF2, IRF3, MAPK8, DDX58, RIPK1, TBK1, RELA, FADD, PIN1, DDX3Y, TRAF6, CYLD, IKBKB, TKFC",1.43062609038495,0.414539270491499,FALSE
+"H2009","Input","KEGG_RNA_DEGRADATION",-0.17392,-0.56,0.976,6984,0.986,"CNOT4, CNOT6L, XRN1, CNOT7, XRN2, DCP2, DIS3, ENO1, PATL1, LSM1, ENO3, TTC37, SKIV2L, DCP1B",0.0105501823333082,0.0061230850587888,FALSE
+"H2009","Input","KEGG_RNA_POLYMERASE",0.4584,1.51,0.0953,3369,0.248,"POLR2D, POLR2L, POLR1E, POLR2I, POLR2K, POLR2G, POLR3K, POLR2J, POLR2C, POLR2F, POLR2E, POLR3H, POLR3F, POLR3D, POLR1C, POLR1D, POLR2A, POLR2H",1.02090709936167,0.605548319173784,FALSE
+"H2009","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.38989,-1.25,0.202,5400,0.409,"MAT2B, GGT1, TRMT11, SEPHS2, AHCYL1, AHCYL2, PAPSS2, MAT2A, BUD23, METTL2B, CTH, SCLY, MAT1A, LCMT1, AHCY, CBS, LCMT2",0.694648630553376,0.388276691992658,FALSE
+"H2009","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.31011,1.02,0.372,586,0.531,"LAMC2, TP53, ITGA2B, LAMB3, ITGA6, ITGA3, LAMA3, LAMA4, PIK3R3, ITGA2, LAMB1, ITGAV",0.429457060118102,0.274905478918531,FALSE
+"H2009","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.29441,0.958,0.432,2020,0.548,"VAMP8, GOSR1, STX17, VAMP4, STX10, STX6, GOSR2, STX12",0.364516253185088,0.261219441515631,FALSE
+"H2009","Input","KEGG_SPHINGOLIPID_METABOLISM",0.48509,1.67,0.044,483,0.214,"PLPP2, NEU1, UGT8, PLPP3, GLA",1.35654732351381,0.669586226650809,TRUE
+"H2009","Input","KEGG_SPLICEOSOME",0.5245,1.68,0.0628,2839,0.219,"ISY1, PHF5A, HNRNPA3, SNRNP70, SRSF1, SNRPB, PRPF4, PRPF40B, SF3B4, HNRNPC, SNRPC, U2AF1, PPIE, SNRPG, U2AF2, SRSF9, NCBP2, SNRPD3, TRA2A, SF3B5, SNRPF, DHX8, TCERG1, PUF60, THOC3, SRSF10, RBM25, SRSF3, SF3B2, PRPF40A, SRSF7, LSM8, SRSF8, PRPF3, DDX5, LSM4, SF3B6, RBMX, TRA2B, LSM6, SNRPA1, SNRPA, HNRNPA1, SRSF4, SF3A1, HNRNPK, DDX23, SF3B1, SRSF5, BCAS2, U2SURP, DDX46, SRSF6, LSM7, DHX38, PPIH, ALYREF, DDX42, PRPF19, ZMAT2, RBM17, RBM8A, SNRNP40, PQBP1, SNRPB2, THOC1, LSM2, HSPA1L, SF3A3, SRSF2, PRPF38A, SNW1, SF3B3",1.2020403562628,0.659555885159882,FALSE
+"H2009","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.389,-1.23,0.215,5667,0.404,"UGT2B11, UGT2B4, PYGB, GUSB, AGL, PYGL, UGP2, GCK, HK3, PGM2, PGM1, GYS1, GBE1, GPI",0.667561540084395,0.393618634889395,FALSE
+"H2009","Input","KEGG_STEROID_BIOSYNTHESIS",0.4863,1.62,0.0394,1862,0.223,"MSMO1, SOAT1, FDFT1, HSD17B7, SQLE, CYP27B1, DHCR24, NSDHL",1.40450377817443,0.651695136951839,TRUE
+"H2009","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.34609,-1.12,0.288,7659,0.467,"AKR1C1, AKR1C3, AKR1D1, CYP21A2",0.540607512240769,0.330683119433888,FALSE
+"H2009","Input","KEGG_SULFUR_METABOLISM",0.47416,1.56,0.0818,2177,0.232,"CHST11, SULT1A3, CHST12, PAPSS1",1.08724669632868,0.6345120151091,FALSE
+"H2009","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.27638,-0.887,0.583,7154,0.7,"C3, C9, C4A, TRIM21, CTSG",0.234331445240986,0.154901959985743,FALSE
+"H2009","Input","KEGG_TASTE_TRANSDUCTION",-0.3025,-0.954,0.462,8567,0.619,"ADCY6, PLCB2",0.335358024443874,0.208309350979882,FALSE
+"H2009","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.47856,-1.55,0.0698,6679,0.355,"FDPS, PMVK, MVK, ACAT2, IDI1, MVD, GGPS1",1.15614457737684,0.449771646944906,FALSE
+"H2009","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.32172,-1.04,0.375,6779,0.524,"ZFYVE16, BMPR2, PPP2CA, ROCK1, RPS6KB1, ID3, AMH, RPS6KB2, PPP2R1B, MAPK1, ROCK2, SMAD2, SMAD5, SMAD9, SMAD1, TGFB3, MAPK3, PPP2CB",0.425968732272281,0.280668713016273,FALSE
+"H2009","Input","KEGG_THYROID_CANCER",0.38556,1.27,0.183,1410,0.385,"TP53, CTNNB1, CDH1, HRAS, KRAS, NRAS, NCOA4, TPR, MYC",0.737548910269571,0.414539270491499,FALSE
+"H2009","Input","KEGG_TIGHT_JUNCTION",0.30393,0.995,0.407,1297,0.529,"CLDN7, CGN, F11R, CTNNB1, AMOTL1, CTNNA1, TJP3, CTNNA2, CASK, MYH2, MPDZ, PATJ, HRAS, TJP1, VAPA, SPTAN1, ACTN4, KRAS, NRAS, LLGL2, TJP2, AFDN, RAB3B, ASH1L",0.39040559077478,0.276544327964814,FALSE
+"H2009","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.48209,-1.54,0.0848,6703,0.351,"STAT1, TRAF3, MAP3K7, SPP1, MAP2K1, MAPK10, IRAK4, PIK3CB, MAP2K2, IKBKG, NFKB1, MAPK14, MAPK12, MAP2K7, CASP8, IRF3, PIK3R2, MAPK1, MAPK8, MAP2K4, MYD88, RIPK1, TBK1, RELA, AKT1, FADD, MAPK3, PIK3CA, TAB2, TRAF6, PIK3R1, AKT2, IKBKB, MAP2K3",1.07160414774329,0.454692883534176,FALSE
+"H2009","Input","KEGG_TRYPTOPHAN_METABOLISM",0.32458,1.09,0.293,1258,0.498,"ALDH1B1, MAOA, ACAT1, ECHS1, HADH, HADHA",0.533132379645891,0.302770657240282,FALSE
+"H2009","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.44209,-1.39,0.116,6930,0.344,"GCK, PKM, MAPK10, MTOR, HK3, PIK3CB, PIK3R2, MAPK1, MAPK8, PRKCZ, PKLR, MAPK3, PIK3CA, PIK3R1, SOCS2, IKBKB",0.935542010773082,0.46344155742847,FALSE
+"H2009","Input","KEGG_TYROSINE_METABOLISM",-0.52439,-1.66,0.0368,6402,0.334,"TAT, MAOB, FAH, BUD23, METTL2B, DDC, DCT, MIF, PNMT, LCMT1, NAA80, ALDH3A1, GSTZ1, ADH5, LCMT2",1.43415218132648,0.476253533188435,FALSE
+"H2009","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.43728,-1.42,0.125,6633,0.371,"BCL10, VAV3, PPP3CC, PTPN6, MAP3K7, NCK2, MAP2K1, PAK3, PIK3CB, NFKBIB, PAK2, MAP2K2, NCK1, IKBKG, PRKCQ, NFKB1, MAPK14, MAPK12, SOS1, MAP2K7, NFATC2, PIK3R2, MAPK1, VAV2, NFKBIE, RELA, CBL, AKT1, MAPK3, PIK3CA, GSK3B, PIK3R1, AKT2, PLCG1, MALT1, CBLB, IKBKB, RAF1",0.903089986991944,0.430626090384954,FALSE
+"H2009","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.3559,-1.13,0.291,7777,0.482,"UBE2O, PIAS2, UBE2M, CDC34, UBE2L3, SIAH1, FBXW8, CUL2, BIRC6, NEDD4L, CUL7, UBE2R2, UBE2G1, NEDD4, CBL, HERC1, UBE2D2, UBE2N, DDB2, UBE3C, UBE2E1, UBE2D4, UBA1, TRAF6, UBE2NL, HERC4, UBE3B, CBLB, UBE3A, PIAS4",0.536107011014093,0.31695296176115,FALSE
+"H2009","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.48592,1.56,0.078,1659,0.232,"PDHA1, PDHB, BCAT2",1.10790539730952,0.6345120151091,FALSE
+"H2009","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.58129,1.91,0.0111,2597,0.21,"ACADM, ALDH1B1, OXCT1, ACAA1, DBT, MCEE, ACAT1, ECHS1, HADHB, HADH, HADHA, MCCC2, PCCB, ACADSB, BCAT2, ALDH2, PCCA, AUH, ALDH7A1, BCKDHA, HMGCL, BCKDHB, ALDH3A2",1.95467702121334,0.677780705266081,TRUE
+"H2009","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.46886,-1.48,0.0945,5982,0.364,"ARHGEF11, ITPR2, PRKCD, PRKG1, MYL6, ARHGEF12, GNAS, PRKACA, PRKCA, PLCB3, MAP2K1, PRKCB, ROCK1, GUCY1A1, MAP2K2, PRKCQ, ARHGEF1, MAPK1, GNA12, ROCK2, ARAF, MYH11, ADCY5, BRAF, KCNMA1, MAPK3, ADCY6, CALD1, PLCB4, GNA13, PLCB2, RAF1",1.02456819149074,0.438898616350944,FALSE
+"H2009","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.35698,-1.15,0.267,7018,0.468,"DYNC2LI1, DCTN4, DCTN5, DCTN6, ARHGDIA, DCTN2, DYNC1LI2, DCTN1, DYNC1I2, ADCY6, DYNC1LI1, DYNC1H1",0.573488738635425,0.329754146925876,FALSE
+"H2009","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.30473,-0.98,0.433,6980,0.591,"MAP2K1, PRKCB, PXN, PIK3CB, CASP9, PLCG2, MAP2K2, HSPB1, MAPK14, MAPK12, PTK2, NFATC2, PIK3R2, MAPK1, MAPKAPK2, AKT1, MAPK3, PIK3CA, PIK3R1, AKT2, PLCG1, RAF1",0.363512103646635,0.228412519118745,FALSE
+"H2009","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.37068,-1.23,0.184,6251,0.404,"GNAS, ATP6V0C, PRKACA, PRKCA, ACTG1, SEC61B, ATP6V1C2, ATP6V1D, SEC61A1, SLC12A2, PRKCB, ATP6V1E1, ATP6V1G1, PLCG2, ATP6V1H, ATP6V1B2, ATP6V1B1, ATP6V1A, ATP6V1C1, PLCG1",0.735182176990464,0.393618634889395,FALSE
+"H2009","Input","KEGG_VIRAL_MYOCARDITIS",0.30864,1.03,0.346,425,0.526,"ITGB2, RAC2, CD55, MYH2",0.460923901207223,0.279014255846261,FALSE
+"H2009","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.18723,-0.605,0.949,6125,0.976,"WNT5A, DVL2, SMAD4, CUL1, PRKACA, PRKCA, NFAT5, CSNK2A1, CSNK2A2, MAPK9, PPP2R1A, PPP3CC, MAP3K7, PLCB3, PPP2CA, MAPK10, PRKCB, CACYBP, ROCK1, PPP2R5C, CAMK2B, DVL3, PPP2R1B, CCND3, NFATC2, PPP2R5B, MAPK8, ROCK2, SIAH1, SMAD2, PPP2R5E, PPP2CB, NLK, PPP2R5A, GSK3B, PPP2R5D, PLCB4, PLCB2, CCND1",0.0227337875727074,0.0105501823333082,FALSE
+"H2126","Input","KEGG_ABC_TRANSPORTERS",0.59912,1.72,0.0387,1103,0.206,"ABCG2, ABCB6, ABCD1, ABCC3, ABCC2, ABCB8",1.41228903498109,0.686132779630847,TRUE
+"H2126","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.22995,-0.706,0.837,7987,0.999,"TCF7L2, MYC, CCND1, PIK3R3, PML",0.07727454200674,0.000434511774017692,FALSE
+"H2126","Input","KEGG_ADHERENS_JUNCTION",0.25036,0.728,0.789,1346,1,"NECTIN4, LMO7, PTPRM, CDH1, RAC2, WASL, CTNNA1, PTPRF, TGFBR1, IQGAP1, CTNNA2, RAC3",0.10292299679058,0,FALSE
+"H2126","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.51611,1.49,0.0841,2311,0.331,"PRKAB2, PRKAB1, PRKAG1, ACSL1, PRKAA1, ADIPOR1, PRKAG2, ACSL3, IRS2, NFKBIB, PRKAA2, CPT1A, IKBKG, SLC2A1, IKBKB, TRAF2, ACSL5, ACACB, ACSL6, AKT1, RELA, MTOR, CHUK, RXRG, RXRA",1.07520400420209,0.480172006224281,FALSE
+"H2126","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32409,-0.98,0.424,8469,0.823,"GFPT2, GLS, GLS2, DDO",0.372634143407267,0.0846001647877302,FALSE
+"H2126","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.20958,-0.64,0.936,7781,1,"PRKCB, IRS1, PIK3R3",0.0287241512618947,0,FALSE
+"H2126","Input","KEGG_ALZHEIMERS_DISEASE",0.25428,0.75,0.796,2827,1,"ATP2A3, ITPR1, CASP9, NDUFA2, BID, UQCRH, EIF2AK3, CACNA1F, CAPN2, CYC1, CDK5, PSEN2, UQCR10, IDE, SNCA, CHP1, NDUFB1, NDUFAB1, ATP2A2, NDUFA9, MAPK3, UQCRQ, NDUFC2, ATP5MC2, NDUFB7, CYCS, NDUFV2, NDUFS6, UQCRB, NDUFA5, NDUFB6, PSEN1, CASP7, FAS, NDUFA7, NDUFC1, CASP3, NDUFS4",0.0990869322623309,0,FALSE
+"H2126","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.21908,0.637,0.93,1725,1,"TARS2, NARS2, SEPSECS, VARS2, PARS2",0.0315170514460649,0,FALSE
+"H2126","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.51946,1.49,0.0913,2147,0.331,"GNPNAT1, FPGT, GFPT1, GNPDA2, GALK2, NANS, PMM2, GNE, UGDH, PGM3, UXS1, GMDS, HK1, PGM2, PGM1, PMM1, MPI, GMPPA, GALE, CYB5R3, AMDHD2, NAGK, CYB5R1",1.0395292224657,0.480172006224281,FALSE
+"H2126","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.32373,-1.02,0.372,7922,0.784,"NEFH, PRPH, PRPH2, GRIN1, BCL2L1, MAP2K6, TOMM40L, CASP1, TP53, GPX1",0.429457060118102,0.105683937315562,FALSE
+"H2126","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.24207,-0.73,0.779,7492,1,"RFXANK, HSPA4, RFX5, CD74, TAP1, CTSS, CTSB",0.108462542327436,0,FALSE
+"H2126","Input","KEGG_APOPTOSIS",0.22094,0.645,0.904,2238,1,"CASP9, MYD88, BID, CAPN2, BIRC2, BAX, AIFM1, IKBKG, XIAP, CHP1, IKBKB, TRAF2, AKT1, IRAK4, RELA, ENDOG, CYCS, CHUK",0.0438315695246367,0,FALSE
+"H2126","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.5093,1.48,0.0915,812,0.314,"PTGES, PLA2G12A, PLA2G4A, GPX2, LTA4H",1.03857890593355,0.503070351926785,FALSE
+"H2126","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.33614,0.979,0.439,989,0.723,"AGMAT, GLUL, CKMT1A, PYCR1, CKMT2, GAMT, CPS1, GATM, OAT, ODC1, SRM, ALDH18A1",0.357535479757879,0.140861702705469,FALSE
+"H2126","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.53299,-1.63,0.0472,7855,0.655,"LAMA2, TCF7L2, ITGB8, CACNA2D2, ITGA2B, ITGA2, DSC2, ITGA6, ACTN1, LMNA, ITGA10, ITGB4, ACTG1, SGCB, CDH2, ITGB3, GJA1, CACNA2D1",1.32605800136591,0.183758700008217,FALSE
+"H2126","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.37229,-1.13,0.26,7617,0.707,"ALDH1B1, ALDH9A1",0.585026652029182,0.150580586203101,FALSE
+"H2126","Input","KEGG_AXON_GUIDANCE",-0.42414,-1.29,0.175,7255,0.661,"ROBO1, EFNA5, ABLIM1, SEMA4B, PAK3, SRGAP2, SRGAP3, EPHA7, DPYSL5, PLXNA1, ABLIM2, CXCR4, CFL2, GNAI1, EPHB3, PLXNA2, ABLIM3, PAK2, EPHB2, NFAT5, EPHA2, EPHA6, EPHA5, SEMA3A, DPYSL2, EFNB1, EPHA4, PLXNB3, NFATC2, EFNB2, SEMA5A",0.756961951313706,0.17979854051436,FALSE
+"H2126","Input","KEGG_BASAL_CELL_CARCINOMA",-0.6756,-2.11,0.012,7503,0.364,"WNT5A, SUFU, FZD1, TCF7L2, GLI2, GLI3, FZD7, TP53",1.92081875395238,0.438898616350944,FALSE
+"H2126","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.54803,-1.68,0.0535,5616,0.749,"GTF2F1, GTF2E1, GTF2E2, GTF2IRD1, TAF5, TAF4, GTF2F2, TAF9, TAF6L, GTF2I, GTF2A1, TAF7, GTF2H2, TAF5L, GTF2H1, GTF2B, GTF2A2",1.27164621797877,0.125518182300534,FALSE
+"H2126","Input","KEGG_BASE_EXCISION_REPAIR",-0.16099,-0.484,0.994,6400,1,"POLD3, MBD4, POLL, POLE3, POLD2, LIG1, FEN1, POLD1, POLE, POLE2",0.00261361560268669,0,FALSE
+"H2126","Input","KEGG_BETA_ALANINE_METABOLISM",0.31702,0.903,0.534,900,0.815,"ACADM, SRM",0.272458742971444,0.0888423912600234,FALSE
+"H2126","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.35363,1.02,0.409,2304,0.693,"ACOX3, HACD1, ELOVL5, ACAA1, ACOT2, SCD, FADS2, ACOT1, TECR",0.388276691992658,0.159266765388193,FALSE
+"H2126","Input","KEGG_BLADDER_CANCER",-0.40679,-1.25,0.194,7877,0.687,"DAPK1, MMP1, MYC, CCND1, CDKN2A, TP53, THBS1",0.712198270069774,0.16304326294045,FALSE
+"H2126","Input","KEGG_BUTANOATE_METABOLISM",-0.52691,-1.59,0.0714,7606,0.549,"ALDH5A1, ALDH1B1, BDH1, ALDH9A1, BDH2, HMGCS2, ACSM3, OXCT1",1.14630178822383,0.260427655549908,FALSE
+"H2126","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.24858,-0.751,0.77,7781,1,"PRKCB, CARD11, BTK, LYN, NFAT5, JUN, PIK3R3, NFATC2, CD79A",0.113509274827518,0,FALSE
+"H2126","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2744,0.79,0.72,2265,0.985,"ATP2A3, ITPR1, CACNA1A, CD38, PHKA1, ATP2B1, SLC25A5, CACNA1F, VDAC2, LTB4R2, P2RX4, GNA11, PHKB, CHP1, ERBB3, ATP2A2, PHKG2, HRH1, SLC25A31, PHKA2, TACR1, SLC25A6, PPID, SPHK2",0.142667503568732,0.00656376950238827,FALSE
+"H2126","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.2875,-0.879,0.544,7402,0.933,"COX6B1, COX7C, TPM2, CACNA2D2, COX6A1, COX7A2, CACNA2D1",0.26440110030182,0.0301183562535,FALSE
+"H2126","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.31486,0.91,0.523,449,0.814,"CLDN3, CDH5, CLDN7, PTPRM, CD40, ITGB2, CDH1",0.281498311132726,0.0893755951107988,FALSE
+"H2126","Input","KEGG_CELL_CYCLE",-0.29725,-0.915,0.491,6666,0.931,"SMC1A, PRKDC, WEE1, CDK4, CREBBP, SMAD4, E2F3, PLK1, RBL1, MCM2, RAD21, SMC1B, CCNA2, MAD2L1, SMC3, HDAC1, MCM7, MCM6, SMAD3, MCM3, CDKN2D, ORC6, MAD1L1, CDC25C, MCM4, MYC, ATR, PTTG1, CCND1, TGFB2, CDKN2A, TP53, CDK6, CDKN2C",0.308918507877032,0.0310503190186574,FALSE
+"H2126","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.17888,-0.539,0.986,7139,1,"PLCB2, PLCB3, PREX1, VAV1, ELMO1, GRK6, CXCR4, PRKCB, GNB4, GNAI1, CXCL5, LYN, ADCY3, ADCY8, WAS, GNG7, CCL5, PIK3R3, GNG4",0.0061230850587888,0,FALSE
+"H2126","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.37521,-1.19,0.231,6791,0.608,"CDK4, NFKB1, SMAD4, E2F3, CTBP2, RUNX1, HDAC1, BAD, SMAD3, TGFBR2, BCL2L1, MYC, CCND1, TGFB2, MECOM, CDKN2A, GAB2, TP53, CDK6, PIK3R3",0.636388020107856,0.216096420727265,FALSE
+"H2126","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.67963,1.95,0.00905,862,0.197,"BHLHE41, PER2, CSNK1E",2.0433514207948,0.705533773838407,TRUE
+"H2126","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.26045,0.748,0.775,2193,1,"ACLY, IDH2, DLAT, MDH2, IDH1, SUCLG2, DLST, DLD",0.11069829749369,0,FALSE
+"H2126","Input","KEGG_COLORECTAL_CANCER",-0.26635,-0.823,0.627,7455,1,"BAD, APPL1, SMAD3, TCF7L2, TGFBR2, MYC, CCND1, TGFB2, JUN, TP53, PIK3R3",0.202732459169284,0,FALSE
+"H2126","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.47122,1.38,0.122,256,0.368,"FGA, FGG, TFPI, FGB, MASP1, PLAUR",0.913640169325252,0.434152181326482,FALSE
+"H2126","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.28799,0.842,0.648,2023,0.905,"CTH, ENOPH1, LDHA, SRM, ADI1, GOT1, AHCYL1, TAT",0.188424994129407,0.0433514207947967,FALSE
+"H2126","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.38952,-1.19,0.207,7335,0.608,"IL1RAP, BMPR2, TNFRSF10A, CXCR4, PLEKHO2, TNFRSF21, ACVR2A, CXCL5, CD70, TGFBR2, IFNAR1, TNFRSF10D, IL6ST, TGFB2, TNFRSF10B, CCL5, INHBA, NGFR",0.684029654543082,0.216096420727265,FALSE
+"H2126","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.2747,-0.822,0.635,8380,0.99,"ZBP1, TREX1, CASP1, CCL5",0.197226274708024,0.00436480540245009,FALSE
+"H2126","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.47591,-1.46,0.102,7835,0.532,"TPM2, LAMA2, ITGB8, CACNA2D2, ADCY3, ADCY8, ITGA2B, ITGA2, TGFB2, ITGA6, LMNA, ITGA10, ITGB4, ACTG1, SGCB, ITGB3, CACNA2D1",0.991399828238082,0.274088367704952,FALSE
+"H2126","Input","KEGG_DNA_REPLICATION",-0.41424,-1.29,0.164,6307,0.661,"POLA2, POLD3, RPA3, POLE3, POLD2, POLA1, MCM2, LIG1, FEN1, PRIM2, MCM7, POLD1, MCM6, POLE, MCM3, POLE2, MCM4",0.785156151952302,0.17979854051436,FALSE
+"H2126","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.23097,-0.723,0.811,7978,1,"NOTCH2, NOTCH1",0.090979145788844,0,FALSE
+"H2126","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.46523,1.38,0.115,487,0.368,"ALDH3B1, GSTM3, GSTK1, MGST2, MGST1, ALDH1A3, GSTZ1",0.939302159646388,0.434152181326482,FALSE
+"H2126","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.31743,0.922,0.54,929,0.802,"CDA, CES1, CES2, TYMP, TPMT",0.267606240177031,0.0958256317158365,FALSE
+"H2126","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.55437,-1.71,0.0514,7522,0.813,"ITGA3, COL5A1, COL5A2, LAMB3, SPP1, COL1A1, LAMC2, LAMA2, COL4A2, CD47, COL6A1, LAMB2, LAMC1, ITGB8, HMMR, COL1A2, ITGA2B, FN1, ITGA2, ITGA6, ITGA10, ITGB4, THBS1, ITGB3, THBS2, COL6A2, COL4A1",1.28903688100472,0.0899094544059319,FALSE
+"H2126","Input","KEGG_ENDOCYTOSIS",0.30537,0.894,0.592,2973,0.821,"ARRB1, CHMP2A, ARFGAP1, ARFGAP3, USP8, DAB2, CHMP2B, HSPA2, PIKFYVE, RAB31, ARRB2, PSD, RAB11FIP4, SMURF1, ACAP1, VPS37C, CHMP5, RAB11A, ASAP2, STAM2, CHMP4A, CHMP4B, CHMP1B, PIP5K1C, VPS25, PLD2, ERBB3, VPS45, EHD1, AP2A1, SNF8, RAB22A, NEDD4, PLD1, CHMP4C, CLTC, RAB11B, HSPA1L, SH3GL1, CDC42, ITCH, AP2M1, SMAP1, HSPA6, CHMP3, HSPA1A, RAB5B, DNAJC6, VPS37A, CBL, STAMBP, EGFR, VPS36",0.22767829327708,0.0856568428805592,FALSE
+"H2126","Input","KEGG_ENDOMETRIAL_CANCER",-0.20567,-0.622,0.941,7987,1,"TCF7L2, MYC, CCND1, TP53, PIK3R3",0.0264103765727431,0,FALSE
+"H2126","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.22622,-0.687,0.816,8136,1,"LYN, ATP6V1B2, JUN, CCL5, HBEGF, PTPRZ1",0.0883098412461389,0,FALSE
+"H2126","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.25997,-0.818,0.681,6992,0.983,"NCK1, PAK1, CAMK2D, PAK3, PLCG2, BAD, PRKCB, CAMK2B, MYC, PAK2, JUN, HBEGF, NRG1, PIK3R3, CAMK2G",0.166852888087215,0.00744648216786438,FALSE
+"H2126","Input","KEGG_ETHER_LIPID_METABOLISM",0.50907,1.48,0.0887,2183,0.314,"PLA2G12A, PLA2G4A, PAFAH2, PLPP3, PLD2, PLD1, PAFAH1B3, PLA2G7",1.05207638016827,0.503070351926785,FALSE
+"H2126","Input","KEGG_FATTY_ACID_METABOLISM",-0.27864,-0.855,0.581,7617,0.96,"ALDH1B1, ADH4, ADH7, ACADSB, ADH1C, ALDH9A1, ACAA2, GCDH, ECI1, ACSL4",0.235823867609669,0.0177287669604316,FALSE
+"H2126","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.2122,0.609,0.949,2447,1,"PLA2G12A, PLA2G4A, RAC2, PRKCD, VAV2, RAC3, MAPK13, RAC1, AKT1, MAPK3, GRB2, PDPK1, MAPK12, SOS1",0.0227337875727074,0,FALSE
+"H2126","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.22441,-0.69,0.865,8136,1,"LYN, ARPC1A, PTPRC, SCIN, WAS, ASAP3, PLPP1, GAB2, WASF1, PIK3R3",0.0629838925351858,0,FALSE
+"H2126","Input","KEGG_FOCAL_ADHESION",-0.35199,-1.08,0.286,7522,0.738,"ITGA3, COL5A1, COL5A2, LAMB3, SPP1, COL1A1, PRKCB, LAMC2, LAMA2, COL4A2, COL6A1, LAMB2, LAMC1, ITGB8, COL1A2, PAK2, ITGA2B, CCND1, FLNA, FN1, ITGA2, ITGA6, JUN, ACTN1, CAV1, FLNC, ITGA10, ITGB4, THBS1, PIK3R3, ACTG1, MYLK, ITGB3, THBS2, COL6A2, COL4A1",0.543633966870957,0.131943638176958,FALSE
+"H2126","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.51847,-1.61,0.0682,8658,0.564,"ALPI, ALPP, ALPG",1.16621562534352,0.248720896016658,FALSE
+"H2126","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.5654,1.62,0.0592,1756,0.249,"FBP1, ALDOB, PHPT1, FPGT, FBP2, PFKFB4, PMM2, GMDS, HK1, AKR1B1, PMM1, MPI, GMPPA, SORD",1.22767829327708,0.603800652904264,FALSE
+"H2126","Input","KEGG_GALACTOSE_METABOLISM",0.33023,0.959,0.466,2577,0.75,"GALK2, B4GALT1, HK1, PGM2, AKR1B1, PGM1, GALE, PFKP, HK2, GALK1",0.33161408331,0.1249387366083,FALSE
+"H2126","Input","KEGG_GAP_JUNCTION",-0.22428,-0.68,0.861,7005,1,"GNAS, PLCB2, PLCB3, CSNK1D, TUBA4A, PRKCB, GNAI1, ITPR3, TUBB4A, ADCY3, ADCY8, GJA1",0.0649968485463452,0,FALSE
+"H2126","Input","KEGG_GLIOMA",-0.38925,-1.19,0.224,8123,0.608,"CAMK2B, CCND1, CDKN2A, TP53, CDK6, PIK3R3, CAMK2G",0.649751981665837,0.216096420727265,FALSE
+"H2126","Input","KEGG_GLUTATHIONE_METABOLISM",0.50785,1.47,0.101,1457,0.311,"GSTM3, GSTK1, MGST2, MGST1, G6PD, TXNDC12, GPX2, GSTZ1, RRM2, IDH2, ODC1, SRM, MGST3, IDH1, RRM1",0.995678626217357,0.507239610973163,FALSE
+"H2126","Input","KEGG_GLYCEROLIPID_METABOLISM",0.28383,0.818,0.666,1849,0.942,"GK2, AKR1A1, DGAT1, AKR1B1, PLPP3, DGKE, AGK, GPAT4, MGLL",0.176525770829699,0.0259490972071227,FALSE
+"H2126","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.40749,1.16,0.26,2154,0.561,"LPGAT1, PLA2G12A, PEMT, PLA2G4A, CDS1, MBOAT7, PTDSS2, PISD, PLPP3, DGKE, LYPLA2, PLD2, GPAT4, LPCAT3, PLD1, PTDSS1, GPAM",0.585026652029182,0.251037138743839,FALSE
+"H2126","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.37929,1.09,0.302,675,0.607,"CTH, GAMT, GATM, GLDC, GCAT",0.519993057042849,0.216811308924742,FALSE
+"H2126","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.36834,1.06,0.348,1343,0.625,"FBP1, ALDOB, ALDH3B1, ALDH1A3, FBP2, GALM, AKR1A1, ACSS2, LDHA, DLAT, HK1, PGK1, BPGM, PGM2, PGM1",0.458420756053419,0.204119982655925,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.34847,1.01,0.43,1989,0.7,"B3GAT3, CHPF2, CHST12, B4GALT7",0.366531544420413,0.154901959985743,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.3983,1.14,0.269,1989,0.568,"HS6ST2, B3GAT3, EXT1, B4GALT7",0.570247719997592,0.245651664288981,FALSE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.70892,2.05,0.00916,652,0.141,"ST3GAL2, ST3GAL1, B4GALT4, B4GALT1",2.03810452633215,0.85078088734462,TRUE
+"H2126","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.69667,-2.15,0.00888,8038,0.575,"GLB1, ARSB, HEXB, HEXA, SGSH, HPSE",2.0515870342214,0.24033215531037,FALSE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.5861,1.68,0.0346,101,0.224,"ST3GAL2, ST3GAL1",1.46092390120722,0.649751981665837,TRUE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.59275,1.72,0.042,101,0.206,"ST3GAL2, ST3GAL1",1.3767507096021,0.686132779630847,TRUE
+"H2126","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.7532,2.2,0.00614,652,0.0668,"B3GNT3, ST3GAL4, B4GALT4, B4GALT1",2.21183162885883,1.17522353752445,TRUE
+"H2126","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.81012,2.35,0.00156,1328,0.0643,"PIGO, PIGU, PIGA, PIGK, PIGT, GPAA1, PIGS",2.80687540164554,1.19178902707578,TRUE
+"H2126","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.29087,0.842,0.65,1256,0.905,"MDH2, PGP",0.187086643357144,0.0433514207947967,FALSE
+"H2126","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.25041,0.717,0.83,266,1,"ITPR1, ADCY5, PLA2G12A, PLA2G4A",0.0809219076239261,0,FALSE
+"H2126","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.52487,-1.63,0.0696,7343,0.655,"CSNK1D, WNT5A, SUFU, RAB23, GLI2, GLI3",1.15739076038944,0.183758700008217,FALSE
+"H2126","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.50948,-1.55,0.0856,8329,0.525,"ITGA2B, ITGA2, ITGA6, CD33, ITGB3, CD7",1.06752623532285,0.279840696594043,FALSE
+"H2126","Input","KEGG_HISTIDINE_METABOLISM",0.45345,1.33,0.157,478,0.411,"ALDH3B1, BUD23, ALDH1A3, METTL2B",0.804100347590766,0.386158178123931,FALSE
+"H2126","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.22331,0.644,0.92,1620,1,"MUS81, SSBP1, RAD51, BLM",0.0362121726544447,0,FALSE
+"H2126","Input","KEGG_HUNTINGTONS_DISEASE",-0.14886,-0.46,0.997,7136,0.998,"NDUFB9, PLCB2, PLCB3, POLR2L, BBC3, COX6B1, POLR2E, HDAC1, POLR2G, ATP5F1B, ATP5F1E, COX7C, ATP5PD, POLR2F, ATP5F1A, DLG4, ATP5PO, GRIN1, COX6A1, TP53, NDUFA4, COX7A2, GPX1, HIP1",0.00130484168834428,0.000869458712628891,FALSE
+"H2126","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.40467,-1.21,0.222,7835,0.669,"TPM2, LAMA2, ITGB8, CACNA2D2, ITGA2B, ITGA2, TGFB2, ITGA6, LMNA, ITGA10, ITGB4, ACTG1, SGCB, ITGB3, ACE, CACNA2D1",0.653647025549361,0.174573882232177,FALSE
+"H2126","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.21722,0.622,0.945,1643,1,"OCRL, INPP4B, PIKFYVE, PIP4K2C, PI4KB, PIP5K1C, ITPK1, IMPA2, ALDH6A1",0.0245681914907371,0,FALSE
+"H2126","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.37326,1.06,0.348,2333,0.625,"FBP1, PRKAB2, MKNK1, FBP2, PRKAB1, PRKAG1, PHKA1, PRKAA1, GYS1, PRKAG2, PYGL, RHEB, IRS2, PTPRF, HK1, PRKAA2, PYGM, RPS6KB2, SREBF1, PPP1R3D, PHKB, IKBKB, ACACB, AKT1, PHKG2, MTOR, MAPK3, PHKA2, GRB2, SHC1, ACACA, ARAF, HK2, PDPK1",0.458420756053419,0.204119982655925,FALSE
+"H2126","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.42663,1.23,0.19,978,0.51,"CD40, LTBR",0.721246399047171,0.292429823902064,FALSE
+"H2126","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.42385,-1.3,0.157,8043,0.702,"IRF9, IFNAR1, BCL2L1, MYC, IL6ST, CCND1, PIAS2, SPRED1, SPRY4, PIK3R3, SPRY1",0.804100347590766,0.153662887870195,FALSE
+"H2126","Input","KEGG_LEISHMANIA_INFECTION",-0.23821,-0.73,0.844,8390,1,"TGFB2, JUN, C3, CYBA",0.073657553374345,0,FALSE
+"H2126","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.22884,0.673,0.886,1784,1,"CLDN3, CDH5, CLDN7, ITGB2, RAC2, CTNNA1, PXN, VAV2, VASP, CTNNA2, ROCK1, OCLN, F11R, CTNND1, MAPK13, RAC1",0.0525662781129492,0,FALSE
+"H2126","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.52114,-1.58,0.0629,7617,0.519,"ALDH1B1, ALDH9A1",1.20134935455473,0.284832642151542,FALSE
+"H2126","Input","KEGG_LONG_TERM_DEPRESSION",0.40839,1.18,0.227,266,0.539,"ITPR1, PLA2G12A, CACNA1A, PLA2G4A",0.643974142806877,0.268411234813261,FALSE
+"H2126","Input","KEGG_LONG_TERM_POTENTIATION",-0.24765,-0.766,0.761,7139,1,"PLCB2, PLCB3, CAMK2D, PRKCB, ITPR3, GRIN1, CAMK2B, ADCY8, CAMK2G",0.118615343229427,0,FALSE
+"H2126","Input","KEGG_LYSINE_DEGRADATION",-0.39531,-1.2,0.252,6028,0.647,"PLOD3, NSD1, NSD2, TMLHE, ACAT1, SETD1A, EHMT2, SUV39H1, SETDB2, SETDB1, NSD3, SETD2, ALDH1B1, ALDH9A1, GCDH, SETMAR, AASS, PLOD2",0.598599459218456,0.1890957193313,FALSE
+"H2126","Input","KEGG_LYSOSOME",-0.28115,-0.887,0.528,7818,0.93,"AP3S1, CTSZ, MFSD8, IGF2R, GLB1, CTSV, PLA2G15, NPC2, CTSF, ARSB, SMPD1, SUMF1, PPT2, AP1S2, MANBA, HEXB, HEXA, CTSS, CTSB, SGSH, CTSK, CTSO",0.277366077466188,0.0315170514460649,FALSE
+"H2126","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.23147,-0.712,0.805,7646,1,"DAXX, RPS6KA4, MAPKAPK3, PRKCB, SRF, RRAS2, TGFBR2, CACNA2D2, MYC, FGF13, FGF2, NTRK2, PAK2, MAP2K6, JUND, FLNA, TGFB2, FGFR2, DUSP16, JUN, MECOM, FLNC, TP53, NFATC2, CACNA2D1",0.0942041196321315,0,FALSE
+"H2126","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.402,1.18,0.232,1039,0.539,"IAPP, PDX1",0.6345120151091,0.268411234813261,FALSE
+"H2126","Input","KEGG_MELANOGENESIS",-0.40343,-1.24,0.196,6863,0.681,"ASIP, CREBBP, GNAS, DCT, PLCB2, PLCB3, CAMK2D, WNT5A, PRKCB, FZD1, GNAI1, TCF7L2, MITF, CAMK2B, ADCY3, ADCY8, FZD7, CAMK2G",0.707743928643524,0.166852888087215,FALSE
+"H2126","Input","KEGG_MELANOMA",-0.43512,-1.34,0.176,8000,0.658,"MITF, FGF13, FGF2, CCND1, CDKN2A, TP53, CDK6, PIK3R3",0.75448733218585,0.181774106386044,FALSE
+"H2126","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.49098,1.43,0.0986,487,0.344,"ALDH3B1, GSTM3, GSTK1, MGST2, CYP1B1, MGST1, ALDH1A3, GSTZ1",1.00612308505879,0.46344155742847,FALSE
+"H2126","Input","KEGG_MISMATCH_REPAIR",0.15748,0.461,0.997,7463,1,"SSBP1, RFC1, MSH3, PCNA, POLD4, MLH3, RFC5, MSH6, RFC3, MSH2, RFC2, RPA1, RPA2, PMS2, RFC4, MLH1, POLD3, RPA3, POLD2, LIG1, POLD1",0.00130484168834428,0,FALSE
+"H2126","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.41873,1.21,0.23,2504,0.529,"CAB39L, PRKAA1, CAB39, RHEB, PRKAA2, RPS6KB2, EIF4B, AKT1, MTOR, MAPK3, RICTOR, PDPK1, MLST8",0.638272163982407,0.276544327964814,FALSE
+"H2126","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.29637,-0.907,0.504,7327,0.933,"VAV1, PLCG2, TNFRSF10A, PRKCB, IFNAR1, TNFRSF10D, ULBP1, NFAT5, TNFRSF10B, PIK3R3, RAET1L, ULBP2, NFATC2",0.297569463554475,0.0301183562535,FALSE
+"H2126","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.40933,1.19,0.238,2607,0.551,"PRSS3, LTB4R2, P2RX4, HRH1, TSPO, P2RY11, TACR1, HCRTR1, MAS1",0.623423042943488,0.258848401148215,FALSE
+"H2126","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.16712,-0.517,0.991,7214,1,"TRAF6, CAMK2D, PLCG2, BAD, KIDINS220, RPS6KA4, IRS1, CAMK2B, NTRK2, JUN, TP53, PIK3R3, NGFR, CAMK2G",0.00392634551472468,0,FALSE
+"H2126","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.40558,-1.23,0.221,8093,0.676,"PNP, NNT, NT5E, BST1, NMNAT3, NUDT12",0.655607726314889,0.170053304058364,FALSE
+"H2126","Input","KEGG_NITROGEN_METABOLISM",-0.48123,-1.51,0.0693,8739,0.551,"CA2, GLS, GLS2, CA12",1.15926676538819,0.258848401148215,FALSE
+"H2126","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.20752,0.598,0.947,2371,0.989,"CCL13, TAB3, NFKBIB, BIRC2, IKBKG, XIAP, IKBKB, MAPK13, RELA, MAPK3, CHUK, MAPK12, SUGT1",0.0236500209967266,0.0048037084028206,FALSE
+"H2126","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.38277,-1.2,0.209,6694,0.647,"POLL, PRKDC, FEN1, NHEJ1",0.679853713888946,0.1890957193313,FALSE
+"H2126","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.26276,-0.812,0.677,8344,0.981,"CCND1, CDKN2A, TP53, CDK6, PIK3R3",0.169411331314856,0.0083309926200515,FALSE
+"H2126","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.47003,-1.46,0.105,6681,0.532,"SNW1, NCOR2, NUMBL, RBPJ, CREBBP, JAG1, JAG2, CTBP2, DLL3, MAML1, HDAC1, NOTCH2, DTX3L, MAML2, NOTCH1",0.978810700930062,0.274088367704952,FALSE
+"H2126","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.19128,-0.596,0.959,6021,1,"RFC4, ERCC2, ERCC6, POLD3, RPA3, POLE3, POLD2, XPC, GTF2H2, LIG1, POLD1, GTF2H1, POLE, POLE2",0.0181813928293364,0,FALSE
+"H2126","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.60494,1.74,0.0262,2635,0.237,"MGAT4A, ST6GAL1, ALG5, ALG8, DPAGT1, ALG9, DPM3, ALG13, ALG3, ALG6, B4GALT1, DOLPP1, DPM1, MAN1B1, MOGS, MAN1A1, STT3B, RPN2, ALG1, MAN2A1, ALG2, ALG14, STT3A, B4GALT3, MGAT1, RFT1, DAD1, DDOST, MAN2A2, ALG11",1.58169870868025,0.625251653989896,TRUE
+"H2126","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.46831,-1.45,0.0917,6939,0.519,"CNGB1, CAMK2D, CAMK2B, ADCY3, CAMK2G",1.03763066432998,0.284832642151542,FALSE
+"H2126","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.34213,-1.1,0.272,6014,0.714,"MTHFD1, MTHFS, GART, SHMT2, MTHFD1L, ALDH1L1",0.565431095965801,0.146301788223826,FALSE
+"H2126","Input","KEGG_OOCYTE_MEIOSIS",0.15329,0.447,1,123,0.999,"ITPR1, ADCY5",0,0.000434511774017692,FALSE
+"H2126","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.5262,-1.61,0.0506,6833,0.564,"MAN2B2, GBA, FUCA2, MAN2B1, GLB1, MANBA, HEXB, HEXA",1.2958494831602,0.248720896016658,FALSE
+"H2126","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.1508,-0.477,1,7354,1,"ATP6V1H, COX6B1, ATP6V1A, ATP5MG, ATP5F1B, ATP5F1E, COX7C, ATP5PD, ATP5ME, ATP5F1A, ATP5PO, COX6A1, ATP6V1B2, NDUFA4, COX7A2",0,0,FALSE
+"H2126","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.67285,1.93,0.0128,106,0.155,"GCNT3, GALNT6, ST3GAL2, ST3GAL1, GALNT3",1.89279003035213,0.809668301829709,TRUE
+"H2126","Input","KEGG_P53_SIGNALING_PATHWAY",-0.33435,-1.04,0.351,8005,0.757,"COP1, ATR, CCND1, TNFRSF10B, CDKN2A, TP53, CDK6, THBS1, STEAP3, SERPINE1",0.454692883534176,0.120904120499927,FALSE
+"H2126","Input","KEGG_PANCREATIC_CANCER",-0.22021,-0.706,0.856,8046,0.999,"TGFBR2, BCL2L1, CCND1, TGFB2, CDKN2A, TP53, CDK6, PIK3R3",0.0675262353228468,0.000434511774017692,FALSE
+"H2126","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.45499,1.32,0.139,536,0.412,"ENPP1, PPCDC, PPCS",0.856985199745905,0.385102783966865,FALSE
+"H2126","Input","KEGG_PARKINSONS_DISEASE",0.24269,0.705,0.824,2827,1,"CASP9, NDUFA2, UQCRH, SLC25A5, CYC1, VDAC2, UBA7, UBE2L3, UQCR10, SNCA, UBE2J1, NDUFB1, NDUFAB1, SLC18A1, NDUFA9, UQCRQ, SLC25A31, NDUFC2, ATP5MC2, NDUFB7, SLC25A6, CYCS, PPID, UBE2G2, PARK7, NDUFV2, NDUFS6, UCHL1, UBE2G1, UQCRB, NDUFA5, NDUFB6, NDUFA7, NDUFC1, CASP3, NDUFS4",0.0840727883028842,0,FALSE
+"H2126","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.23423,-0.715,0.824,8023,1,"TUBB4A, ARHGEF2, ARPC1A, HCLS1, WAS, ACTG1",0.0840727883028842,0,FALSE
+"H2126","Input","KEGG_PATHWAYS_IN_CANCER",-0.29321,-0.893,0.568,7429,0.932,"HDAC1, PLCG2, BAD, APPL1, WNT5A, ITGA3, SUFU, SMAD3, LAMB3, PRKCB, LAMC2, FZD1, LAMA2, DAPK1, COL4A2, TPR, TCF7L2, LAMB2, MITF, LAMC1, TGFBR2, MMP1, FOXO1, BCL2L1, MYC, FGF13, FGF2, ITGA2B, CCND1, FN1, ITGA2, FH, TGFB2, FGFR2, ITGA6, JUN, GLI2, GLI3, PIAS2, FZD7, MECOM, CDKN2A, GSTP1, TP53, CDK6, PIK3R3, PML, COL4A1",0.245651664288981,0.0305840876460186,FALSE
+"H2126","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.46733,1.37,0.118,1831,0.369,"UGDH, AKR1B1, DCXR",0.928117992693875,0.43297363384094,FALSE
+"H2126","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.62853,1.79,0.0192,1343,0.229,"FBP1, ALDOB, G6PD, FBP2, PRPS1, PRPS1L1, PRPS2, PGM2, RBKS, PGM1",1.71669877129645,0.640164517660112,TRUE
+"H2126","Input","KEGG_PEROXISOME",0.47747,1.39,0.125,1757,0.384,"GSTK1, ACOX3, ABCD1, PXMP4, SCP2, PRDX1, ACSL1, ACAA1, ACSL3, IDH2, ECH1, SLC27A2, PEX1, SLC25A17, MPV17, PEX26, PMVK, PEX13, MVK, CAT, CRAT, IDH1, PEX16, AMACR, ACSL5, ACSL6, XDH",0.903089986991944,0.415668775632469,FALSE
+"H2126","Input","KEGG_PHENYLALANINE_METABOLISM",0.39329,1.13,0.291,1031,0.573,"ALDH3B1, ALDH1A3, MIF",0.536107011014093,0.24184537803261,FALSE
+"H2126","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.25005,0.72,0.829,1584,1,"ITPR1, OCRL, CDS1, INPP4B, PIKFYVE, PIP4K2C, PI4KB, PIP5K1C, DGKE, ITPK1, IMPA2",0.0814454694497265,0,FALSE
+"H2126","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.27965,-0.855,0.607,7910,0.96,"ALAS1, FECH, FTH1",0.216811308924742,0.0177287669604316,FALSE
+"H2126","Input","KEGG_PPAR_SIGNALING_PATHWAY",0.44366,1.28,0.172,872,0.443,"FABP6, FABP3, ACADM, ACOX3, OLR1, SCP2, GK2, ACSL1, ACAA1, ACSL3, SLC27A2, FABP5",0.764471553092451,0.35359627377693,FALSE
+"H2126","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.37483,-1.11,0.283,7144,0.71,"RFXAP, RFXANK, RFX5, BTK, TAP1, PTPRC, CD79A",0.54821356447571,0.148741651280925,FALSE
+"H2126","Input","KEGG_PRION_DISEASES",-0.32574,-1.01,0.394,8022,0.788,"LAMC1, NOTCH1, CCL5",0.404503778174426,0.103473782510445,FALSE
+"H2126","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.19384,0.568,0.973,2436,0.995,"ADCY5, FZR1, PKMYT1, ANAPC11, CDC25B, CDC26, MAPK13, AKT1, MAPK3, CDC23, ANAPC4, GNAI3, ARAF, MAPK12, CDC16, ANAPC5",0.0118871597316481,0.00217691925427455,FALSE
+"H2126","Input","KEGG_PROPANOATE_METABOLISM",-0.23567,-0.725,0.818,8092,1,"LDHB, ALDH9A1, ACSS3, ACSS1",0.087246696328677,0,FALSE
+"H2126","Input","KEGG_PROSTATE_CANCER",-0.24166,-0.747,0.795,7987,1,"TCF7L2, FOXO1, CCND1, FGFR2, GSTP1, TP53, PIK3R3",0.0996328713435297,0,FALSE
+"H2126","Input","KEGG_PROTEASOME",-0.17793,-0.562,0.979,2238,1,"PSMA5, PSMF1, PSMB7, POMP, PSMB6, PSMB2, PSMD12, PSMA1, PSMD2, PSMC6, PSMA6, PSMA3, PSMB1, PSMA7, PSMC3, PSMB5, PSMA2, PSMA8, PSMB10, PSMB4, PSMC4, PSMD3, PSMC1, PSME2, PSMD13, PSMD11, PSME1, PSMA4, PSMD4, PSMC2, PSMC5, PSMD6, PSMD1, PSME3, PSMD8, PSMD7, PSMB8, SEM1, PSMD14, PSMB3, PSMB9",0.00921730819686218,0,FALSE
+"H2126","Input","KEGG_PROTEIN_EXPORT",0.66921,1.93,0.0155,2359,0.155,"SRPRB, SRPRA, SEC62, SRP19, SRP54, SEC11C, SRP68, SRP72, SPCS2, SEC61B, SEC61A1, SPCS3, OXA1L",1.80966830182971,0.809668301829709,TRUE
+"H2126","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.66755,-2,0.00576,8416,0.428,"PCK2, CA2, GLS, GLS2",2.23957751657679,0.368556230986828,FALSE
+"H2126","Input","KEGG_PURINE_METABOLISM",0.33619,0.992,0.419,1077,0.724,"PDE4D, ADCY5, PAPSS2, CANT1, FHIT, ENPP1, NME3, RRM2, PRPS1, PRPS1L1, NT5C2, PDE5A, NME1, ADA, NUDT5, GDA, PRPS2, AK1",0.377785977033705,0.140261433802853,FALSE
+"H2126","Input","KEGG_PYRIMIDINE_METABOLISM",0.22053,0.641,0.921,1150,1,"CANT1, CMPK1, CDA, NME3, RRM2, TYMP, TXNRD2, NT5C2, NME1, TXNRD1, CTPS1",0.0357403698031511,0,FALSE
+"H2126","Input","KEGG_PYRUVATE_METABOLISM",-0.29274,-0.901,0.532,8021,0.929,"PKM, LDHB, ME3, ALDH9A1, PCK2, ACSS1",0.274088367704952,0.0319842860063582,FALSE
+"H2126","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.23371,-0.707,0.861,7257,1,"IQGAP2, ABI2, VAV1, ARHGEF7, PAK3, MOS, MSN, ITGA3, CFL2, ENAH, FGD1, RRAS2, ITGB8, FGF13, FGF2, ARPC1A, PAK2, ITGA2B, SCIN, FN1, ITGA2, WAS, FGFR2, ITGA6, ACTN1, ITGA10, ITGB4, WASF1, PIK3R3, ACTG1, MYLK, ITGB3",0.0649968485463452,0,FALSE
+"H2126","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.39457,1.15,0.271,1098,0.565,"PRKAA1, PRKAA2, ATG4C",0.567030709125594,0.247951552180562,FALSE
+"H2126","Input","KEGG_RENAL_CELL_CARCINOMA",-0.26041,-0.789,0.712,8261,1,"PAK2, FH, TGFB2, JUN, FLCN, PIK3R3",0.147520006363144,0,FALSE
+"H2126","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.61812,-1.89,0.0197,7585,0.515,"LNPEP, ANPEP, ACE",1.70553377383841,0.288192770958809,FALSE
+"H2126","Input","KEGG_RETINOL_METABOLISM",-0.40012,-1.25,0.181,7759,0.687,"ADH4, ADH7, ADH1C, DHRS9, ALDH1A2, CYP3A7",0.742321425130815,0.16304326294045,FALSE
+"H2126","Input","KEGG_RIBOFLAVIN_METABOLISM",0.57825,1.66,0.0398,876,0.226,"PHPT1, ENPP1, RFK, ACP6",1.40011692792631,0.645891560852599,TRUE
+"H2126","Input","KEGG_RIBOSOME",0.37424,1.09,0.313,3841,0.607,"RPL37, RPL35, RPL7A, RPL14, RPL18, RPS29, RPL38, RPL29, RPL18A, RPL22, RPL13A, RPS9, RPL36, RPL34, RPL7, RPL10A, RPS5, RPS16, RPL26, RPL23A, RPLP2, RPL30, RPS11, RPL37A, RPS15, RPS18, RPS3, RPL10, RPL15, RPS27A, RPL3, RPL28, RPL6, RPL17, RPL27, RPL35A, RPS13, RPS2, RPS12, UBA52, RPL9, RPS27L, RPS3A, RPS10, RPL19, RPS4X, RPS15A, RPS24, RPS8, RPS17, FAU, RPS25",0.504455662453552,0.216811308924742,FALSE
+"H2126","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.16254,-0.516,0.995,7873,1,"DDX58, AZI2, CYLD, ISG15",0.00217691925427455,0,FALSE
+"H2126","Input","KEGG_RNA_DEGRADATION",-0.30221,-0.936,0.494,5684,0.895,"TENT4A, PARN, C1D, LSM3, LSM7, EXOSC1, EXOSC7, EXOSC5, EXOSC8, EXOSC4, EXOSC3, HSPD1, PNPT1, LSM8, DCPS, LSM2, EXOSC2, DCP2, LSM6, MPHOSPH6, ENO2, DCP1B",0.306273051076353,0.048176964684088,FALSE
+"H2126","Input","KEGG_RNA_POLYMERASE",-0.24479,-0.752,0.783,2161,1,"POLR3K, POLR3B, POLR3C, POLR3F, POLR2I, POLR3GL, POLR3A, POLR3H, POLR3D, POLR2C, POLR2B, POLR1C, POLR1D, POLR1A, POLR1B, POLR2H, POLR2J, POLR3G, POLR1E, POLR2K, POLR2D, POLR2A, POLR2L, POLR2E, POLR2G, POLR2F",0.106238237942057,0,FALSE
+"H2126","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.4481,1.28,0.189,478,0.443,"PAPSS2, BUD23, CTH, METTL2B",0.723538195826756,0.35359627377693,FALSE
+"H2126","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.3302,-1,0.414,7663,0.793,"LAMB3, LAMC2, LAMA2, COL4A2, LAMB2, LAMC1, BCL2L1, MYC, ITGA2B, CCND1, FN1, ITGA2, ITGA6, PIAS2, TP53, CDK6, PIK3R3, COL4A1",0.382999658879101,0.100726812682396,FALSE
+"H2126","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.36545,1.07,0.337,2249,0.632,"STX16, SEC22B, YKT6, VAMP7, BNIP1, BET1L, STX18, SNAP47, VAMP3, VTI1B, SNAP23, GOSR1, SNAP29",0.472370099128661,0.199282921717615,FALSE
+"H2126","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.3853,-1.21,0.213,8038,0.669,"GLB1, KDSR, SMPD1, PLPP1, UGT8",0.671620396561262,0.174573882232177,FALSE
+"H2126","Input","KEGG_SPLICEOSOME",-0.36522,-1.12,0.288,5534,0.709,"RBM8A, SF3B5, SNRPD1, SNRPD2, HNRNPU, ACIN1, SNRPG, PQBP1, SRSF5, SRSF6, PRPF18, LSM3, LSM7, SRSF10, WBP11, PPIL1, RBMX, HNRNPC, SNRPC, SF3B6, SRSF1, MAGOHB, ALYREF, SRSF7, TCERG1, SNRNP27, PRPF31, RBM25, SF3B3, ISY1, SF3A3, U2AF2, SRSF3, ZMAT2, CTNNBL1, SNRPB, DDX39B, SRSF2, EFTUD2, SNRPF, BUD31, SRSF8, CWC15, LSM8, SNW1, PLRG1, PRPF38A, DDX42, LSM2, SMNDC1, HNRNPA1, SYF2, TRA2B, SNU13, BCAS2, RBM17, EIF4A3, PRPF40A, RBM22, SLU7, SNRNP40, CDC5L, SRSF4, HNRNPA3, U2SURP, CDC40, HNRNPM, LSM6, PRPF19, TRA2A, HNRNPK, TXNL4A",0.540607512240769,0.149353764816933,FALSE
+"H2126","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.60943,1.75,0.0237,1343,0.248,"ENPP1, GYS1, PYGL, UGDH, UXS1, HK1, PYGM, PGM2, PGM2L1, PGM1",1.6252516539899,0.605548319173784,TRUE
+"H2126","Input","KEGG_STEROID_BIOSYNTHESIS",0.62732,1.8,0.0226,831,0.247,"MSMO1, DHCR24, SC5D, NSDHL, FDFT1, DHCR7",1.6458915608526,0.607303046740334,TRUE
+"H2126","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.55637,1.59,0.059,521,0.266,"SULT2B1, SRD5A3, CYP1B1, COMT, CYP21A2",1.22914798835786,0.575118363368933,FALSE
+"H2126","Input","KEGG_SULFUR_METABOLISM",0.78472,2.27,0,216,0.0628,"SULT2B1, SULT1A3, PAPSS2",Inf,1.2020403562628,TRUE
+"H2126","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.49155,-1.49,0.105,7521,0.549,"SSB, TRIM21, C1S, ACTN1, C3, C1R",0.978810700930062,0.260427655549908,FALSE
+"H2126","Input","KEGG_TASTE_TRANSDUCTION",0.32059,0.93,0.507,209,0.799,"CACNA1A",0.294992040666664,0.0974532206860086,FALSE
+"H2126","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.59573,1.73,0.0322,1468,0.228,"IDI1, PDSS2, FDPS, MVD, PMVK, MVK, HMGCR",1.49214412830417,0.642065152999546,TRUE
+"H2126","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.2805,-0.841,0.594,6878,0.977,"CREBBP, SMAD4, SMAD1, RBL1, BMPR2, SMAD3, ACVR2A, TGFBR2, MYC, TGFB2, INHBA, FST, THBS1, THBS2",0.226213555018806,0.0101054362812269,FALSE
+"H2126","Input","KEGG_THYROID_CANCER",-0.35137,-1.05,0.364,7959,0.77,"TPR, TCF7L2, MYC, CCND1, TP53",0.438898616350944,0.113509274827518,FALSE
+"H2126","Input","KEGG_TIGHT_JUNCTION",0.26989,0.789,0.705,1863,0.971,"CLDN3, MYH3, CLDN7, EPB41L3, EPB41L1, TJP3, RAB13, CGN, CTNNA1, LLGL2, PRKCD, AMOTL1, CTNNA2, VAPA, OCLN, F11R, PATJ, EXOC4, AKT1, CTTN",0.151810883008601,0.0127807700919951,FALSE
+"H2126","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.18618,-0.579,0.971,7601,1,"TOLLIP, TLR3, SPP1, IFNAR1, MAP2K6, JUN, CCL5, PIK3R3, CTSK",0.0127807700919951,0,FALSE
+"H2126","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.44076,-1.34,0.152,7325,0.658,"CYP1A1, WARS2, ALDH1B1, ALDH9A1, GCDH, KYNU, MAOB",0.818156412055227,0.181774106386044,FALSE
+"H2126","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.26787,0.774,0.769,1039,0.986,"CACNA1A, IRS2, PRKCD, HK1, PDX1",0.114073660198569,0.0061230850587888,FALSE
+"H2126","Input","KEGG_TYROSINE_METABOLISM",0.53264,1.54,0.0843,487,0.304,"HGD, ALDH3B1, COMT, BUD23, ALDH1A3, METTL2B, GSTZ1",1.07417242537526,0.517126416391246,FALSE
+"H2126","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.17534,-0.539,0.994,8256,1,"PTPRC, PAK2, NFAT5, JUN, PIK3R3, NFATC2",0.00261361560268669,0,FALSE
+"H2126","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.23048,0.666,0.903,3037,1,"FZR1, ANAPC11, SYVN1, MID1, UBE2Q1, BIRC2, PIAS3, HERC1, UBE4A, SMURF1, UBE2M, UBA7, RNF7, UBE2L3, XIAP, RCHY1, BRCA1, PPIL2, UBE2NL, CUL4A, CDC26, CUL4B, UBE2J1, UBE3C, MGRN1, UBE2N, NEDD4, CDC23, ANAPC4, CUL2, UBE2G2, UBE2A, CDC16, STUB1, ANAPC5, HERC4, ELOC, ITCH, UBE2G1, UBE2F, BIRC6, CUL1, TRIP12, TRIM37, ELOB, CBL, CUL7, UBE2Z, CUL3, HERC2, UBE2C, UBE2D2",0.0443122496864942,0,FALSE
+"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.34285,-1.06,0.301,6260,0.765,"PDHA1, PDHB, LARS2, BCAT1",0.521433504406157,0.116338564846382,FALSE
+"H2126","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.34823,-1.04,0.346,7932,0.757,"ACADSB, ALDH9A1, ACAA2, HMGCS2, BCAT1, OXCT1, IVD",0.460923901207223,0.120904120499927,FALSE
+"H2126","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.33844,0.98,0.445,1500,0.735,"ITPR1, ADCY5, PLA2G12A, PLA2G4A, CACNA1F, PRKCD, MYL6, GNA11, ROCK1",0.351639989019068,0.133712660915805,FALSE
+"H2126","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.20693,0.608,0.941,2718,0.993,"AQP3, ARHGDIB, RAB11A, NSF, RAB11B, DCTN5, DYNC1LI2, DYNC1H1, RAB5B",0.0264103765727431,0.00305075150461883,FALSE
+"H2126","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23268,0.677,0.897,2337,1,"PLA2G12A, CASP9, PLA2G4A, RAC2, PXN, RAC3, CHP1, MAPK13, RAC1, AKT1, MAPK3, HSPB1, SPHK2, MAPK12",0.0472075569559079,0,FALSE
+"H2126","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.24131,0.699,0.854,1995,1,"KDELR3, TCIRG1, PDIA4, ERO1A, KDELR1, SEC61B, ATP6V0A1, ATP6V0D1, ATP6V1B1, ATP6V0C",0.068542129310995,0,FALSE
+"H2126","Input","KEGG_VIRAL_MYOCARDITIS",0.38191,1.11,0.287,528,0.596,"MYH3, CASP9, CD40, ITGB2, RAC2, BID",0.542118103266008,0.224753740259764,FALSE
+"H2126","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.30079,-0.941,0.465,6878,0.902,"CREBBP, SMAD4, CACYBP, SIAH1, CTBP2, PLCB2, PLCB3, CAMK2D, WNT5A, TBL1X, TBL1XR1, LRP6, SMAD3, PRKCB, FZD1, TCF7L2, CAMK2B, MYC, FOSL1, NFAT5, CCND1, JUN, FZD7, TP53, NFATC2, CAMK2G",0.332547047110046,0.0447934624580583,FALSE
+"H3255","Input","KEGG_ABC_TRANSPORTERS",-0.34284,-1.05,0.344,9404,0.805,"ABCA1, ABCB4, ABCD1, ABCG2",0.46344155742847,0.0942041196321315,FALSE
+"H3255","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.22699,0.695,0.876,2513,0.937,"CEBPA, CCND1, RUNX1, BAD, TCF7L1, STAT3, RARA, IKBKG, HRAS, AKT1, TCF7L2, PIK3R3, IKBKB",0.0574958938319193,0.0282604091122217,FALSE
+"H3255","Input","KEGG_ADHERENS_JUNCTION",0.2297,0.714,0.813,957,0.936,"EGFR, LMO7, FGFR1, NECTIN4, EP300, AFDN, ERBB2, CTNNB1",0.0899094544059319,0.0287241512618947,FALSE
+"H3255","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.18008,-0.539,0.992,7785,1,"JAK2, CPT1C, PTPN11, ACACB, TRAF2, CAMKK2, SLC2A1, MAPK8, MAPK10, PRKCQ, IRS2",0.00348832784582135,0,FALSE
+"H3255","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.32832,-0.987,0.42,9035,0.824,"ABAT, NIT2, GFPT2, GLUD2",0.3767507096021,0.0840727883028842,FALSE
+"H3255","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.31997,-0.965,0.461,8484,0.845,"PIK3CB, SFN, ATP1B3, IRS2",0.336299074610352,0.0731432910503077,FALSE
+"H3255","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.45433,1.36,0.125,71,0.649,"FADS2, PLA2G4A",0.903089986991944,0.187755303199631,FALSE
+"H3255","Input","KEGG_ALZHEIMERS_DISEASE",-0.15801,-0.477,0.998,6846,1,"GSK3B, NDUFA9, CASP3, PLCB3, ATP5F1A, NDUFS2, NDUFB7, UQCR10, UQCRQ, MAPK3, CASP9, CHP1, ATP5F1C, GNAQ, GRIN1, NAE1, PLCB2, ATF6, ATP5F1E, CAPN1, ATP5PB, CASP7, PPP3CC, CYC1, PLCB4, NDUFA2, MAPT, LPL, IDE, LRP1, PSEN2, FADD, CACNA1F, SNCA",0.000869458712628891,0,FALSE
+"H3255","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.47743,-1.46,0.102,8698,0.67,"LARS2, DARS2, WARS2, SEPSECS, CARS2",0.991399828238082,0.173925197299174,FALSE
+"H3255","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.29991,-0.894,0.561,8555,0.861,"GNPDA1, GPI, FPGT, PGM2, GNE, UAP1, GFPT2, PGM1, GALK2",0.251037138743839,0.0649968485463452,FALSE
+"H3255","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.40337,-1.19,0.238,9454,0.736,"MAP2K6, NEFL, PRPH, PRPH2, NEFH, TP53",0.623423042943488,0.133122185662501,FALSE
+"H3255","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.25406,-0.748,0.742,8500,0.906,"RFX5, CTSL, HSP90AB1, RFXAP, HSPA2, NFYA, CD74",0.129596094720973,0.0428718023231869,FALSE
+"H3255","Input","KEGG_APOPTOSIS",-0.29435,-0.876,0.594,7123,0.806,"BAX, EXOG, CASP9, RELA, CHP1, CHUK, TNFRSF10C, DFFB, IRAK1, XIAP, CAPN1, DFFA, TRAF2, IRAK3, CASP7, PIK3CB, PPP3CC, ATM, IRAK2, IRAK4, BIRC2, TNFRSF10B, TNFRSF10D, FADD, TP53",0.226213555018806,0.0936649581949093,FALSE
+"H3255","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.40376,1.25,0.194,279,0.536,"GGT5, PTGS2, PLA2G4A, GGT1",0.712198270069774,0.27083521030723,FALSE
+"H3255","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.40906,1.26,0.171,1416,0.541,"ARG2, PRODH, PRODH2, ODC1, ALDH2, PYCR1, GLUL, GAMT, ALDH3A2, GLS, GLS2, OAT, MAOA, PYCR2, CKB, ALDH4A1",0.767003889607846,0.266802734893431,FALSE
+"H3255","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.58775,-1.75,0.0362,8939,0.688,"SLC8A1, CACNA2D1, ITGB3, LEF1, ITGB1, CDH2, CACNA1F, ITGA5, ITGB8, ITGA6, DES, DSC2, DSG2",1.44129142946683,0.162411561764489,FALSE
+"H3255","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.3471,1.07,0.329,1816,0.67,"ALDH2, ALDH3A2, UGDH",0.482804102050026,0.173925197299174,FALSE
+"H3255","Input","KEGG_AXON_GUIDANCE",-0.28258,-0.846,0.62,8086,0.837,"PAK2, SRGAP2, SRGAP3, PAK3, SEMA5A, FYN, EPHB6, SRGAP1, NCK1, EFNA5, GNAI2, PPP3CC, RAC2, EFNB2, NCK2, CXCR4, RASA1, NFATC1, ABLIM3, SEMA7A, ITGB1, NFAT5, L1CAM, SEMA3F, EFNB1, ROBO1",0.207608310501746,0.07727454200674,FALSE
+"H3255","Input","KEGG_BASAL_CELL_CARCINOMA",-0.62416,-1.89,0.00938,9283,1,"LEF1, FZD7, WNT10A, WNT7A, GLI2, TP53",2.02779716162094,0,FALSE
+"H3255","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.12719,-0.396,1,7915,1,"TBPL1, GTF2F2, GTF2F1, GTF2B",0,0,FALSE
+"H3255","Input","KEGG_BASE_EXCISION_REPAIR",0.24011,0.746,0.794,2064,0.938,"LIG3, POLE2, POLE4, XRCC1, POLE, POLE3, POLB, POLD4",0.100179497572904,0.0277971616209356,FALSE
+"H3255","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29132,-0.903,0.574,8443,0.853,"SRM, ABAT, ALDH1B1, ALDH7A1",0.241088107602027,0.069050968832477,FALSE
+"H3255","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.42747,1.3,0.16,1479,0.565,"FADS2, ACAA1, ACOT2, PECR, HSD17B12, SCD5, ACOX1",0.795880017344075,0.247951552180562,FALSE
+"H3255","Input","KEGG_BLADDER_CANCER",-0.29424,-0.889,0.562,8246,0.823,"TYMP, RASSF1, MMP1, MAP2K1, RAF1, ARAF, CDKN2A, TP53",0.250263684430939,0.0846001647877302,FALSE
+"H3255","Input","KEGG_BUTANOATE_METABOLISM",0.3346,1.02,0.376,1824,0.742,"OXCT1, ALDH2, HMGCS1, ALDH3A2, ALDH5A1, ACAT2, BDH2, EHHADH",0.424812155072339,0.129596094720973,FALSE
+"H3255","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.4408,-1.36,0.117,8461,0.741,"SOS1, PIK3CB, PPP3CC, RAC2, BCL10, INPP5D, MAP2K1, RAF1, NFATC1, CARD11, MALT1, BLNK, NFAT5, CD79A, PLCG2, CD79B",0.931814138253838,0.130181792020672,FALSE
+"H3255","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.23461,-0.696,0.836,8456,0.944,"F2R, CD38, PPP3CC, PHKA1, PLCB4, ATP2B2, ATP2B4, PHKB, SLC8A1, BST1, PHKG2, TRPC1, MYLK, PDE1C, CACNA1F, PLCD3, PLCG2",0.0777937225609836,0.025028005701931,FALSE
+"H3255","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.32017,-0.962,0.463,8541,0.823,"CYC1, ATP1B3, SLC8A1, CACNA2D1, CACNA1F, TPM2",0.334419008982047,0.0846001647877302,FALSE
+"H3255","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.30421,0.953,0.476,1197,0.783,"ICAM1, SDC2, CLDN3, VCAN, CADM1, SDC1, CDH15, CDH3, OCLN, CLDN4, SDC3",0.322393047279507,0.106238237942057,FALSE
+"H3255","Input","KEGG_CELL_CYCLE",-0.25617,-0.768,0.77,8299,0.878,"ESPL1, CDK2, YWHAQ, CDC26, PLK1, ATM, CHEK1, SMC1B, SFN, CDK1, CDKN2C, YWHAZ, TFDP1, TFDP2, TGFB2, CDKN2A, ORC3, TP53",0.113509274827518,0.0565054840938974,FALSE
+"H3255","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.29396,-0.891,0.566,8412,0.855,"GNAI2, CXCL5, SOS1, PIK3CB, GRK6, RAC2, BCAR1, CCR4, CXCR4, PLCB4, SHC4, MAP2K1, CSK, RAF1, ELMO1, DOCK2, WAS, CCR10, CCR9, RASGRP2",0.247183568811729,0.0680338852718274,FALSE
+"H3255","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.29429,-0.889,0.55,7990,0.823,"PTPN11, SHC1, CBLB, SOS1, PIK3CB, STAT5A, SHC4, MAP2K1, RAF1, ARAF, TGFB2, CDKN2A, CBL, TP53",0.259637310505756,0.0846001647877302,FALSE
+"H3255","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",0.26201,0.8,0.7,2625,0.924,"CRY1, CLOCK, PER1, ARNTL",0.154901959985743,0.0343280287798933,FALSE
+"H3255","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.40662,1.29,0.147,2829,0.556,"DLST, ACO1, MDH2, SDHA, OGDHL, OGDH, IDH2, IDH1, SUCLG2, PCK2, DLD, SUCLG1",0.832682665251824,0.254925208417942,FALSE
+"H3255","Input","KEGG_COLORECTAL_CANCER",-0.42461,-1.27,0.184,8484,0.672,"PIK3CB, RAC2, APPL1, MAP2K1, RAF1, ARAF, MAPK8, LEF1, MAPK10, TGFB2, TP53, BIRC5",0.735182176990464,0.172630726946175,FALSE
+"H3255","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.31916,0.986,0.417,1039,0.745,"PLAT, THBD, TFPI, PLAUR, CD55, C4A, F9, CFI, F8",0.379863945026242,0.127843727251707,FALSE
+"H3255","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.35588,-1.08,0.32,6843,0.828,"ADI1, MAT1A, MAT2B, TAT, APIP, GOT2, MAT2A, AHCY, AHCYL1, SDS, SRM, MTAP",0.494850021680094,0.0819696632151199,FALSE
+"H3255","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.27157,0.826,0.67,1302,0.9,"LIFR, EGFR, OSMR, CSF1, TGFB1, CCL28, TNFRSF21, IL1R1, IFNGR1, IL25, VEGFA, LTBR, TNFRSF19, TNFRSF1A, IL1RAP",0.173925197299174,0.0457574905606751,FALSE
+"H3255","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.42134,-1.29,0.172,8691,0.705,"POLR3A, POLR3B, IL6, TBK1, ZBP1, IL18, PYCARD, TREX1",0.764471553092451,0.151810883008601,FALSE
+"H3255","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.47347,-1.46,0.0977,8939,0.67,"SLC8A1, CACNA2D1, ITGB3, ITGB1, TGFB2, CACNA1F, ITGA5, TPM2, ITGB8, ITGA6, DES",1.01010543628123,0.173925197299174,FALSE
+"H3255","Input","KEGG_DNA_REPLICATION",0.39988,1.21,0.205,3839,0.528,"SSBP1, POLE2, POLE4, RPA3, POLE, POLE3, POLD4, RFC3, LIG1, MCM4, MCM3, RFC1, MCM6, POLA2, PCNA, MCM7, PRIM1",0.688246138944246,0.277366077466188,FALSE
+"H3255","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.34053,-1.03,0.383,8461,0.802,"SOS1, NOTCH2, MAP2K1, ETS1, NOTCH1",0.416801226031377,0.0958256317158365,FALSE
+"H3255","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.48669,-1.48,0.0912,8919,0.724,"ALDH3B1, GSTM3, GSTM2, ALDH1A3, GSTM1, GSTO1, ALDH3A1, GSTM4, GSTP1",1.04000516167158,0.140261433802853,FALSE
+"H3255","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.3388,-1.01,0.408,7770,0.816,"UMPS, CES1, CES2, TYMP, GMPS, HPRT1, IMPDH2, UCK2, CDA",0.38933983691012,0.0883098412461389,FALSE
+"H3255","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.43397,-1.29,0.177,8767,0.705,"COL5A2, COL6A2, HSPG2, COL3A1, ITGB3, COL6A1, VTN, COL5A1, ITGB1, LAMA3, LAMA4, ITGA5, COL4A1, ITGB8, COL1A2, COL4A6, ITGA6, COL4A2",0.752026733638193,0.151810883008601,FALSE
+"H3255","Input","KEGG_ENDOCYTOSIS",-0.26473,-0.808,0.685,7952,0.822,"STAM, DNM2, RAB11A, PIP4K2B, CHMP2A, PSD, EHD2, CBLB, WWP1, VTA1, F2R, EHD1, PDCD6IP, GRK6, IGF1R, SH3GLB1, EHD3, ASAP1, CHMP2B, CXCR4, DNM1L, EHD4, ARAP2, VPS4B, SH3GLB2, SNF8, GIT2, ASAP2, HSPA2, VPS36, RAB11FIP2, PIP5K1A, ACAP2, CBL, DNM1, DAB2",0.164309428507574,0.0851281824599496,FALSE
+"H3255","Input","KEGG_ENDOMETRIAL_CANCER",-0.27938,-0.843,0.632,8461,0.813,"SOS1, PIK3CB, ILK, MAP2K1, RAF1, ELK1, ARAF, LEF1, TP53",0.199282921717615,0.0899094544059319,FALSE
+"H3255","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.19706,-0.598,0.953,8738,1,"HBEGF, CSK, MAPK8, MAP2K4, MAPK10, PLCG2",0.0209070993616736,0,FALSE
+"H3255","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.29974,-0.925,0.504,8052,0.855,"SHC1, PAK2, PAK3, ABL2, CBLB, NCK1, SOS1, PIK3CB, NCK2, HBEGF, MAP2K7, STAT5A, SHC4, MAP2K1, RAF1, ELK1, ARAF, MAPK8, MAP2K4, MAPK10, CBL, PLCG2",0.297569463554475,0.0680338852718274,FALSE
+"H3255","Input","KEGG_ETHER_LIPID_METABOLISM",0.39645,1.18,0.239,1097,0.529,"PLA2G4A, LPCAT2, PLPP1, PLA2G12A, PLPP2, PLD1, PAFAH2",0.621602099051862,0.276544327964814,FALSE
+"H3255","Input","KEGG_FATTY_ACID_METABOLISM",0.35348,1.09,0.307,2499,0.647,"ALDH2, ACSL5, ECI2, ACAA1, GCDH, ALDH3A2, ACAT2, ACOX1, ACSL1, ACADSB, EHHADH, ACSL4, ACADVL, ECHS1, ACOX3",0.512861624522813,0.1890957193313,FALSE
+"H3255","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.33913,-1.02,0.384,8221,0.808,"FYN, PLA2G2D, SOS1, PIK3CB, LAT, RAC2, MAP2K7, INPP5D, MAP2K1, RAF1, MAPK8, MAP2K4, MAPK10, MAP2K6, PLCG2, PLA2G6",0.415668775632469,0.0925886392254138,FALSE
+"H3255","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.30258,-0.921,0.517,8331,0.851,"VASP, PIK3CB, LAT, RAC2, ASAP1, DNM1L, INPP5D, MAP2K1, RAF1, DOCK2, WAS, ASAP2, PIP5K1A, DNM1, PLCG2, PLA2G6",0.286509456906058,0.0700704399154121,FALSE
+"H3255","Input","KEGG_FOCAL_ADHESION",-0.41381,-1.26,0.176,7690,0.67,"RAC3, RAP1B, LAMB4, ZYX, FLNB, ITGA3, RAPGEF1, XIAP, SHC1, PAK2, COL6A3, PAK3, FYN, COL1A1, VASP, HGF, SOS1, PIK3CB, FLNA, ILK, IGF1R, RAC2, DIAPH1, VCL, BCAR1, COL5A2, DOCK1, COL6A2, SHC4, MAP2K1, RAF1, ELK1, COL3A1, BIRC2, ITGB3, MAPK8, COL6A1, VTN, MYLK, COL5A1, FLNC, MAPK10, ITGB1, LAMA3, LAMA4, CAV1, ITGA5, COL4A1, ITGB8, PARVB, COL1A2, COL4A6, ITGA6, CAV2, COL4A2",0.75448733218585,0.173925197299174,FALSE
+"H3255","Input","KEGG_FOLATE_BIOSYNTHESIS",0.39984,1.24,0.194,2958,0.514,"GGH, ALPI, ALPP, ALPG, DHFR",0.712198270069774,0.289036881004724,FALSE
+"H3255","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.2781,0.853,0.609,173,0.889,"FBP1, FBP2",0.215382707367125,0.0510982390297863,FALSE
+"H3255","Input","KEGG_GALACTOSE_METABOLISM",-0.35333,-1.07,0.326,8632,0.814,"PGM2, PGM1, GALK2, PFKP",0.486782399932061,0.0893755951107988,FALSE
+"H3255","Input","KEGG_GAP_JUNCTION",0.19907,0.605,0.952,1186,0.968,"EGFR, GUCY1A1, GJA1, PLCB1, ITPR1, MAPK7, ITPR3",0.0213630516155257,0.0141246426916063,FALSE
+"H3255","Input","KEGG_GLIOMA",-0.38066,-1.18,0.23,8461,0.736,"SOS1, PIK3CB, IGF1R, SHC4, MAP2K1, RAF1, ARAF, CDKN2A, PLCG2, TP53",0.638272163982407,0.133122185662501,FALSE
+"H3255","Input","KEGG_GLUTATHIONE_METABOLISM",0.34208,1.04,0.341,423,0.717,"GGT5, GSTA5, ODC1, GGT1, GCLC, MGST1",0.467245621007502,0.1444808443322,FALSE
+"H3255","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.23401,-0.707,0.836,8741,0.946,"DGKD, LPL, ALDH1B1, ALDH7A1, GK2, AGPAT4",0.0777937225609836,0.0241088635982073,FALSE
+"H3255","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.27066,0.816,0.672,2117,0.906,"PLA2G4A, LPCAT2, PEMT, GPD1L, PLPP1, PLA2G12A, PLPP2, PLD1, CHKB, LPGAT1, MBOAT1, LPCAT1, LYPLA2, LPCAT3, PLA2G15, GPD2, PLPP3, CDS1",0.172630726946175,0.0428718023231869,FALSE
+"H3255","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.29789,0.912,0.514,1288,0.859,"PSPH, GCAT, GAMT, MAOA, CTH",0.289036881004724,0.0660068361687577,FALSE
+"H3255","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.32917,-0.983,0.425,8556,0.818,"GPI, PGM2, PGK1, ALDH3B1, PKM, ALDH1B1, PGAM1, PGAM4, ALDH1A3, PKLR, PGM1, ALDH7A1, PFKP, ALDH3A1",0.371611069949688,0.087246696328677,FALSE
+"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.34442,-1.05,0.364,8563,0.805,"CSGALNACT1, CHST13, CHST7, XYLT1, CHST3",0.438898616350944,0.0942041196321315,FALSE
+"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.28566,0.902,0.529,2422,0.829,"HS6ST2, XYLT2, EXT2, GLCE, NDST1, B4GALT7",0.276544327964814,0.0814454694497265,FALSE
+"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.4081,1.26,0.174,2980,0.541,"FUT8, B3GNT2, B4GALT3, B4GALT1, B4GAT1",0.7594507517174,0.266802734893431,FALSE
+"H3255","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.58563,1.77,0.0236,1870,0.277,"SGSH, GUSB, GNS, HEXB, HEXA, NAGLU, HGSNAT",1.62708799702989,0.557520230935551,FALSE
+"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.43302,-1.31,0.155,9836,0.756,"B4GALNT1",0.809668301829709,0.121478204498793,FALSE
+"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.38661,1.2,0.223,1666,0.511,"FUT1, HEXB, HEXA, NAGA",0.651695136951839,0.291579099865287,FALSE
+"H3255","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.41006,-1.21,0.222,9621,0.736,"ABO, B3GALT5",0.653647025549361,0.133122185662501,FALSE
+"H3255","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.5379,1.65,0.0518,2265,0.321,"PIGA, PIGH, PIGS, PIGO, PIGT, PIGK, GPAA1",1.28567024025477,0.493494967595128,FALSE
+"H3255","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.43088,1.33,0.128,3361,0.597,"ACO1, MDH2, MTHFD1L, GRHPR, MTHFD1, CS",0.892790030352132,0.224025668870631,FALSE
+"H3255","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.2673,-0.817,0.68,7175,0.814,"MAP2K2, MAPK3, PLA2G2A, MMP2, MAP3K3, ADCY3, ADCY8, PTK2B, GNAQ, ADCY9, SRC, PLCB2, MAP2K3, MAP3K2, PLA2G2D, SOS1, HBEGF, MAP2K7, PLCB4, MAP2K1, RAF1, ELK1, MAPK8, MAP2K4, MAPK10, MAP2K6, CACNA1F, MMP14, PLA2G6",0.167491087293764,0.0893755951107988,FALSE
+"H3255","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.57521,-1.73,0.0296,9204,0.532,"CSNK1E, WNT10A, WNT7A, GLI2",1.52870828894106,0.274088367704952,FALSE
+"H3255","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.33087,-0.991,0.413,8470,0.83,"CD38, CD59, CD14, IL6, ITGB3, ITGA5, ANPEP, ITGA6, CD33",0.384049948343599,0.0809219076239261,FALSE
+"H3255","Input","KEGG_HISTIDINE_METABOLISM",-0.38446,-1.17,0.255,8384,0.718,"LCMT1, MAOB, ALDH3B1, ALDH1B1, ALDH1A3, ALDH7A1, LCMT2, ALDH3A1",0.593459819566045,0.1438755557577,FALSE
+"H3255","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.23296,-0.7,0.854,8074,0.947,"RAD54B, BRCA2, RAD51, TOP3B, RAD52",0.068542129310995,0.0236500209967266,FALSE
+"H3255","Input","KEGG_HUNTINGTONS_DISEASE",-0.1595,-0.484,0.996,6266,1,"COX7B, NDUFA10, NDUFB3, GPX1, NDUFS1, SDHD, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, DNAL4, SLC25A4, NDUFA9, CASP3, PLCB3, ATP5F1A, DNAL1, NDUFS2, NDUFB7, BAX, UQCR10, UQCRQ, CASP9, SLC25A5, ATP5F1C, GNAQ, GRM5, GRIN1, PLCB2, HTT, DCTN2, TBPL1, ATP5F1E, SP1, ATP5PB, SOD1, PPARG, CYC1, DCTN4, DCTN1, PLCB4, NDUFA2, CREB5, TGM2, TP53",0.00174066157630127,0,FALSE
+"H3255","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.52789,-1.6,0.0641,8939,0.766,"SLC8A1, IL6, CACNA2D1, ITGB3, ITGB1, TGFB2, CACNA1F, ITGA5, TPM2, ITGB8, ITGA6, DES, ACE",1.19314197048118,0.115771230367396,FALSE
+"H3255","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.29939,-0.916,0.535,8484,0.849,"PIK3CB, INPP1, PIK3C3, ITPK1, PLCB4, INPPL1, IMPA1, PIP5K1A, PLCD3, PLCG2",0.271646217978772,0.0710923097560473,FALSE
+"H3255","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.28823,-0.866,0.588,7895,0.806,"EIF4EBP1, RAPGEF1, SHC1, PHKA2, FOXO1, CBLB, ACACB, RPS6, SOS1, PIK3CB, PHKA1, PHKB, SHC4, INPP5D, MAP2K1, RAF1, ELK1, PHKG2, ARAF, MAPK8, PKLR, MAPK10, MKNK1, CBL, SOCS4, IRS2",0.230622673923862,0.0936649581949093,FALSE
+"H3255","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.50237,-1.49,0.0765,8733,0.759,"CXCR4, IL6, CCR10, CCR9, CD40",1.11633856484638,0.11975822410452,FALSE
+"H3255","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.29048,0.869,0.6,1009,0.888,"LIFR, OSMR, CCND1, SPRY2, STAM2, EP300, IFNGR1, STAT2, PIAS3",0.221848749616356,0.051587034221399,FALSE
+"H3255","Input","KEGG_LEISHMANIA_INFECTION",0.3775,1.15,0.262,787,0.567,"PTGS2, MYD88, MAPK12, TGFB1, TLR2, MAPK13, IFNGR1",0.581698708680255,0.246416941107093,FALSE
+"H3255","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.23998,0.743,0.809,1123,0.929,"ICAM1, CLDN3, MAPK12, MAPK13, VAV1, AFDN, ARHGAP35, CTNNB1, OCLN, CLDN4",0.0920514783877277,0.0319842860063582,FALSE
+"H3255","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.32649,1,0.42,1824,0.749,"ALDH2, ALDH3A2, EHHADH",0.3767507096021,0.125518182300534,FALSE
+"H3255","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.38646,-1.17,0.23,9884,0.718,"PLA2G6",0.638272163982407,0.1438755557577,FALSE
+"H3255","Input","KEGG_LONG_TERM_DEPRESSION",0.2406,0.747,0.784,1186,0.952,"PLA2G4A, GUCY1A1, GNAO1, PLCB1, ITPR1, PLA2G12A, ITPR3",0.105683937315562,0.0213630516155257,FALSE
+"H3255","Input","KEGG_LONG_TERM_POTENTIATION",0.16611,0.515,0.988,1186,0.993,"EP300, PLCB1, ITPR1, ATF4, PPP3R1, ITPR3",0.00524305541237188,0.00305075150461883,FALSE
+"H3255","Input","KEGG_LYSINE_DEGRADATION",0.274,0.85,0.616,1537,0.879,"ALDH2, AASS, DLST, GCDH, ALDH3A2, OGDHL, ACAT2, NSD3, OGDH, SETMAR",0.210419287835575,0.0560111249262281,FALSE
+"H3255","Input","KEGG_LYSOSOME",0.59532,1.83,0.0235,1669,0.244,"CTSE, NPC2, NAPSA, LGMN, SGSH, CTSH, LAMP3, CTSC, FUCA1, GALC, PSAP, CTSZ, GUSB, CD63, NEU1, MANBA, ASAH1, GNS, ACP2, GNPTG, ARSA, SCARB2, SMPD1, MFSD8, CLN3, AGA, CLTA, ACP5, MAN2B1, CTSS, NAGPA, HEXB, SORT1, DNASE2, GM2A, HEXA, CTSA, GNPTAB, M6PR, SLC11A2, NAGA, MCOLN1",1.62893213772826,0.612610173661271,TRUE
+"H3255","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.33904,-1.04,0.376,8461,0.811,"SOS1, ATF2, PPP3CC, FLNA, RAC2, STMN1, MAP2K7, NLK, CD14, RASA1, MAP2K1, MAPT, ELK4, RAF1, CACNA2D1, ELK1, DUSP4, DUSP1, MAPK8, PTPN7, MAP2K4, MAP4K4, NFKB2, FLNC, MAPK10, RELB, TGFB2, MAP2K6, HSPA2, CACNA1F, MKNK1, STK4, MOS, FGF13, FGF2, PLA2G6, RASGRP2, TP53",0.424812155072339,0.090979145788844,FALSE
+"H3255","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.2755,-0.843,0.631,9338,0.813,"PKLR",0.199970640755866,0.0899094544059319,FALSE
+"H3255","Input","KEGG_MELANOGENESIS",-0.22541,-0.66,0.891,6728,0.984,"PRKCB, GNAI3, GSK3B, PLCB3, MAP2K2, MAPK3, ADCY3, ADCY8, GNAQ, ADCY9, PLCB2, DCT, FZD2, GNAI2, PLCB4, MAP2K1, RAF1, LEF1, FZD7, WNT10A, WNT7A",0.0501222959631252,0.00700490156865849,FALSE
+"H3255","Input","KEGG_MELANOMA",-0.42238,-1.3,0.148,8460,0.744,"HGF, PIK3CB, IGF1R, MAP2K1, RAF1, ARAF, CDKN2A, FGF13, FGF2, TP53",0.829738284605043,0.128427064454121,FALSE
+"H3255","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.42542,-1.28,0.185,8919,0.675,"ALDH3B1, GSTM3, GSTM2, ALDH1A3, GSTM1, GSTO1, ALDH3A1, GSTM4, GSTP1",0.732828271596986,0.170696227168975,FALSE
+"H3255","Input","KEGG_MISMATCH_REPAIR",0.39045,1.21,0.204,3752,0.528,"SSBP1, RPA3, POLD4, RFC3, LIG1, RFC1, EXO1, MSH3, PCNA, PMS2",0.690369832574101,0.277366077466188,FALSE
+"H3255","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.14959,-0.442,0.998,6026,1,"EIF4E2, AKT2, EIF4B, RPS6KA2, RPS6KB1, ULK3, RPS6KA1, MAPK3, TSC2, TSC1, EIF4EBP1, RPS6, PIK3CB, CAB39L",0.000869458712628891,0,FALSE
+"H3255","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.30955,-0.934,0.498,8461,0.848,"SOS1, PIK3CB, LAT, PPP3CC, LCK, RAC2, SHC4, MAP2K1, RAF1, SH3BP2, NFATC1, ARAF, TNFRSF10B, TNFRSF10D, ICAM2, NFAT5, PRF1, PLCG2",0.302770657240282,0.0716041477432862,FALSE
+"H3255","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.35608,-1.1,0.304,7196,0.823,"PLG, GRM5, GRIN1, PRSS3, NR3C1, F2, F2R, F2RL1",0.517126416391246,0.0846001647877302,FALSE
+"H3255","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.31831,-0.95,0.484,7848,0.838,"YWHAB, IRAK1, RAPGEF1, MAGED1, PTPN11, FOXO3, SHC1, YWHAQ, IRAK3, SOS1, PIK3CB, MAP2K7, RIPK2, SHC4, MAP2K1, IRAK2, CSK, YWHAZ, RAF1, IRAK4, MAPK8, MAPK10, PLCG2, NGFR, IRS2, TP53",0.315154638355588,0.0767559813697235,FALSE
+"H3255","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.41951,1.27,0.171,364,0.57,"ENPP3, NAMPT, NT5E",0.767003889607846,0.244125144327509,FALSE
+"H3255","Input","KEGG_NITROGEN_METABOLISM",-0.51133,-1.53,0.0531,9087,0.72,"CA9, CA12, GLUD2, CA2",1.27490547891853,0.142667503568732,FALSE
+"H3255","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.40053,-1.2,0.251,7187,0.736,"MAPK3, RELA, CHUK, TAB1, CASP1, PYDC1, XIAP, CARD8, TAB3, HSP90AB1, RIPK2, IL6, BIRC2, MAPK8, TNFAIP3, MAPK10, SUGT1, IL18, PYCARD",0.600326278518962,0.133122185662501,FALSE
+"H3255","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.46002,-1.38,0.132,6350,0.731,"DCLRE1C, RAD50, LIG4, POLL, NHEJ1, PRKDC, FEN1",0.87942606879415,0.13608262304214,FALSE
+"H3255","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.35828,-1.11,0.273,8445,0.82,"RASSF1, SOS1, PIK3CB, MAP2K1, RAF1, ARAF, CDKN2A, STK4, PLCG2, TP53",0.563837352959244,0.0861861476162833,FALSE
+"H3255","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.21185,0.638,0.925,3247,0.953,"NCOR2, EP300, HES1, DTX2, NOTCH3, CTBP1, HDAC2, MAML2, PSEN1, CREBBP, SNW1, DVL2, ADAM17, NUMB",0.0338582672609674,0.0209070993616736,FALSE
+"H3255","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.29256,0.904,0.538,3699,0.859,"POLE2, POLE4, ERCC8, RPA3, MNAT1, POLE, DDB2, POLE3, POLD4, RFC3, GTF2H5, DDB1, LIG1, GTF2H2, RFC1, ERCC2, GTF2H1, PCNA, ERCC4, CDK7",0.269217724333611,0.0660068361687577,FALSE
+"H3255","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.39376,1.2,0.223,1704,0.511,"FUT8, ST6GAL1, MGAT4A, MAN1A1, MGAT1, MAN2A2, MOGS, MAN1B1, ALG12, MGAT2, B4GALT3",0.651695136951839,0.291579099865287,FALSE
+"H3255","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.2352,-0.724,0.802,7253,0.928,"ADCY3, CNGB1, PDE1C",0.0958256317158365,0.0324520237811379,FALSE
+"H3255","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.31526,-0.947,0.437,7361,0.831,"MTFMT, GART, ATIC, MTHFR, ALDH1L1",0.359518563029578,0.080398976215889,FALSE
+"H3255","Input","KEGG_OOCYTE_MEIOSIS",-0.26299,-0.797,0.66,6083,0.833,"PRKACB, MAD2L2, CDC16, CDC23, RPS6KA2, PPP2CB, CDC20, ANAPC4, PPP2CA, MAD2L1, PPP1CB, SKP1, SMC3, SMC1A, RPS6KA1, MAPK3, ADCY3, ADCY8, PTTG1, SGO1, CHP1, PPP2R5A, ADCY9, CUL1, CDC25C, YWHAB, PPP2R5D, FBXO5, SLK, ESPL1, CDK2, YWHAQ, CDC26, PPP3CC, PLK1, IGF1R, SMC1B, CDK1, PPP2R1B, MAP2K1, YWHAZ, MOS",0.180456064458131,0.0793549985932124,FALSE
+"H3255","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.61298,1.86,0.0203,1326,0.251,"FUCA1, NEU1, MANBA, AGA, MAN2B1, HEXB, HEXA",1.69250396208679,0.600326278518962,FALSE
+"H3255","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.19406,-0.576,0.983,5496,1,"NDUFB5, NDUFB9, NDUFS8, NDUFA3, NDUFC1, NDUFS5, NDUFS4, UQCRC2, NDUFV2, NDUFS7, COX4I1, NDUFB4, COX7A2L, UQCRC1, COX11, NDUFA6, NDUFV1, ATP6V1H, COX7B, NDUFA11, NDUFA10, NDUFB3, NDUFS1, SDHD, COX17, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, ATP12A, NDUFA9, ATP5F1A, ATP6V1C1, NDUFS2, NDUFB7, UQCR10, UQCRQ, ATP5F1C, PPA1, ATP5MG, ATP5ME, ATP5F1E, COX15, TCIRG1, ATP5PB, CYC1, NDUFA2",0.00744648216786438,0,FALSE
+"H3255","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.76427,2.36,0,1130,0.0732,"GALNT10, GALNT8, GALNT3, GALNT5, GALNT12, GALNT4, GALNT11, C1GALT1, GALNT6, C1GALT1C1, GALNT1, GALNT13, GALNT7",Inf,1.13548891894161,TRUE
+"H3255","Input","KEGG_P53_SIGNALING_PATHWAY",-0.41325,-1.25,0.197,8360,0.668,"CDK2, IGFBP3, ATM, CHEK1, SFN, CDK1, RRM2B, PERP, TNFRSF10B, CDKN2A, SERPINE1, SERPINB5, TP53",0.705533773838407,0.175223537524454,FALSE
+"H3255","Input","KEGG_PANCREATIC_CANCER",-0.28805,-0.874,0.578,8296,0.799,"RAD51, PIK3CB, ARHGEF6, RAC2, MAP2K1, RAF1, ARAF, MAPK8, MAPK10, TGFB2, CDKN2A, TP53",0.238072161579471,0.0974532206860086,FALSE
+"H3255","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.64565,1.98,0.00428,1,0.292,"ENPP3",2.36855623098683,0.534617148551582,FALSE
+"H3255","Input","KEGG_PARKINSONS_DISEASE",-0.27526,-0.819,0.65,5677,0.83,"NDUFC1, NDUFS5, NDUFS4, UQCRC2, NDUFV2, NDUFS7, UBE2L3, COX4I1, NDUFB4, COX7A2L, UQCRC1, NDUFA6, NDUFV1, SLC25A6, COX7B, NDUFA10, NDUFB3, NDUFS1, SDHD, ATP5PO, NDUFA7, COX7C, NDUFB2, NDUFC2, PARK7, SLC25A4, NDUFA9, CASP3, ATP5F1A, NDUFS2, NDUFB7, UQCR10, UQCRQ, CASP9, SLC25A5, ATP5F1C, ATP5F1E, SLC18A1, ATP5PB, CYC1, UBA1, NDUFA2, UCHL1, UBA7, SNCA",0.187086643357144,0.0809219076239261,FALSE
+"H3255","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.31893,-0.962,0.45,8221,0.823,"FYN, NCK1, YWHAQ, TUBA3C, TUBB4B, NCK2, CD14, YWHAZ, TUBAL3, WAS, ITGB1, TUBB6",0.346787486224656,0.0846001647877302,FALSE
+"H3255","Input","KEGG_PATHWAYS_IN_CANCER",-0.36469,-1.09,0.314,8201,0.825,"AXIN2, FZD2, CBLB, RAD51, VHL, CDK2, PPARG, TRAF2, RASSF1, HGF, SOS1, PIK3CB, TFG, IGF1R, RAC2, MMP1, APPL1, HSP90AB1, PAX8, STAT5A, MAP2K1, IL6, RAF1, SLC2A1, EGLN1, ARAF, BIRC2, MAPK8, LEF1, PML, NFKB2, ETS1, MAPK10, FADD, ITGB1, TGFB2, LAMA3, LAMA4, FZD7, WNT10A, CDKN2A, STK4, COL4A1, CBL, COL4A6, ITGA6, WNT7A, PLCG2, COL4A2, GLI2, FGF13, FGF2, GSTP1, TP53, BIRC5",0.503070351926785,0.0835460514500749,FALSE
+"H3255","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.62983,1.99,0.00798,1816,0.415,"GUSB, DCXR, AKR1B1, UGDH",2.09799710864927,0.381951903287907,FALSE
+"H3255","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.29539,0.902,0.545,173,0.829,"FBP1, FBP2",0.263603497723358,0.0814454694497265,FALSE
+"H3255","Input","KEGG_PEROXISOME",0.44275,1.35,0.138,2246,0.63,"AMACR, ACSL5, SLC27A2, ECI2, ACAA1, ECH1, CROT, PECR, DHRS4, PEX16, PXMP4, PEX13, ACOT8, DECR2, PEX6, ACOX1, PEX2, ACSL1, PEX3, IDH2, EHHADH, ACSL4, IDH1, SCP2, MPV17, GSTK1, MVK, PEX26, PEX1",0.860120913598763,0.200659450546418,FALSE
+"H3255","Input","KEGG_PHENYLALANINE_METABOLISM",-0.51143,-1.57,0.0684,6281,0.755,"PRDX6, GOT1, MIF, TAT, GOT2, MAOB, ALDH3B1, ALDH1A3, ALDH3A1",1.16494389827988,0.122053048370812,FALSE
+"H3255","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.29616,-0.903,0.528,7419,0.853,"PIP5K1C, DGKB, DGKQ, PI4KB, PLCB2, SYNJ2, PIP4K2B, DGKE, PIK3CB, INPP1, PIK3C3, ITPK1, DGKD, PLCB4, INPPL1, INPP5D, IMPA1, PIP5K1A, PLCD3, PLCG2",0.277366077466188,0.069050968832477,FALSE
+"H3255","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.36222,1.11,0.3,1507,0.626,"CP, GUSB, ALAD, BLVRA, HMOX1, CPOX",0.522878745280338,0.20342566678957,FALSE
+"H3255","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.45538,-1.35,0.149,9042,0.726,"SLC27A1, FABP7, LPL, SCD, ACADL, GK2, CYP27A1, PLTP, FABP5, OLR1, ANGPTL4",0.826813731587726,0.139063379299906,FALSE
+"H3255","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.56543,1.74,0.0266,1022,0.281,"AMACR, AKR1D1, HSD3B7",1.57511836336893,0.55129368009492,FALSE
+"H3255","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.59581,-1.77,0.0356,8500,0.797,"RFX5, LCK, RFXAP, BLNK, CD79A, CD40",1.44855000202712,0.0985416786038876,FALSE
+"H3255","Input","KEGG_PRION_DISEASES",-0.46458,-1.4,0.108,8221,0.726,"FYN, SOD1, MAP2K1, IL6, ELK1, PRNP, NOTCH1, NCAM1",0.96657624451305,0.139063379299906,FALSE
+"H3255","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.32346,-0.994,0.407,8360,0.838,"CDK2, GNAI2, CDC26, PIK3CB, PLK1, IGF1R, HSP90AB1, CDK1, MAP2K1, RAF1, ARAF, MAPK8, MAPK10, MOS",0.39040559077478,0.0767559813697235,FALSE
+"H3255","Input","KEGG_PROPANOATE_METABOLISM",0.31766,1.01,0.411,2228,0.746,"ALDH2, ALDH6A1, ALDH3A2, ACSS1, LDHB, ACAT2, ACSS2, EHHADH, HIBCH, PCCA, SUCLG2",0.386158178123931,0.127261172527331,FALSE
+"H3255","Input","KEGG_PROSTATE_CANCER",-0.24203,-0.724,0.79,8360,0.928,"CDK2, SOS1, PIK3CB, IGF1R, HSP90AB1, MAP2K1, RAF1, ARAF, CREB5, LEF1, GSTP1, TP53",0.102372908709559,0.0324520237811379,FALSE
+"H3255","Input","KEGG_PROTEASOME",-0.30056,-0.886,0.565,5469,0.818,"PSMD11, PSMB1, PSMA8, PSME3, PSMD8, PSMB4, PSMA7, PSMD13, PSMD7, PSME4, PSMA6, PSMA4, PSMD6, PSMD1, PSMB2, SEM1, PSME2, PSMD3, PSMD12, PSMB8, PSME1, POMP, PSMB10, PSMB9",0.247951552180562,0.087246696328677,FALSE
+"H3255","Input","KEGG_PROTEIN_EXPORT",0.24929,0.781,0.749,2140,0.932,"SRP9, SEC62, IMMP2L, SRP14, OXA1L",0.125518182300534,0.0305840876460186,FALSE
+"H3255","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.47046,-1.45,0.0895,9872,0.65,"GLUD2, CA2",1.04817696468409,0.187086643357144,FALSE
+"H3255","Input","KEGG_PURINE_METABOLISM",0.27566,0.86,0.605,1176,0.891,"ENPP3, ENTPD3, GUCY1A1, ENTPD5, PDE4A, NME4, NT5E, FHIT, POLE2, POLE4, PAPSS2, PDE2A, ENTPD6, CANT1, ADCY10",0.218244625347531,0.0501222959631252,FALSE
+"H3255","Input","KEGG_PYRIMIDINE_METABOLISM",0.25348,0.774,0.725,1136,0.931,"ENTPD3, ENTPD5, NME4, NT5E, TXNRD2, UPP1, POLE2, POLE4, UCK1, ENTPD6, CANT1, CTPS2",0.139661993429006,0.0310503190186574,FALSE
+"H3255","Input","KEGG_PYRUVATE_METABOLISM",0.24477,0.727,0.8,1366,0.929,"ALDH2, ME1, ALDH3A2, ACSS1, MDH2, LDHB, ACAT2, ACSS2",0.0969100130080564,0.0319842860063582,FALSE
+"H3255","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.38963,-1.15,0.277,8086,0.743,"PAK2, PIP4K2B, MSN, ARHGEF7, PAK3, F2, F2R, SOS1, PIK3CB, ARHGEF6, RAC2, DIAPH1, VCL, BCAR1, NCKAP1, BAIAP2, CYFIP1, DOCK1, CD14, MAP2K1, CSK, RAF1, DIAPH3, ARAF, ITGB3, RDX, MYLK, WAS, ITGB1, PIP5K1A, ITGA5, MOS, DIAPH2, ITGB8, ITGA6, FGF13, FGF2, ARHGEF4",0.557520230935551,0.129011186239425,FALSE
+"H3255","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.41874,-1.28,0.155,7595,0.675,"BECN1, GABARAPL1, PIK3C3, ATG3, GABARAPL2, ATG7",0.809668301829709,0.170696227168975,FALSE
+"H3255","Input","KEGG_RENAL_CELL_CARCINOMA",-0.27462,-0.817,0.662,7685,0.814,"CUL2, RAP1B, RAPGEF1, PTPN11, PAK2, PAK3, VHL, HGF, SOS1, PIK3CB, MAP2K1, RAF1, SLC2A1, EGLN1, ARAF, ETS1, TGFB2",0.1791420105603,0.0893755951107988,FALSE
+"H3255","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.64205,-1.88,0.0137,9597,0.999,"ANPEP, CPA3, ACE",1.86327943284359,0.000434511774017692,FALSE
+"H3255","Input","KEGG_RETINOL_METABOLISM",0.27614,0.849,0.615,1532,0.865,"RDH11, DHRS3, DHRS4, CYP3A4",0.211124884224583,0.0629838925351858,FALSE
+"H3255","Input","KEGG_RIBOFLAVIN_METABOLISM",0.6086,1.86,0.0188,904,0.251,"ENPP3, ACP2, ACP5",1.72584215073632,0.600326278518962,FALSE
+"H3255","Input","KEGG_RIBOSOME",-0.59276,-1.77,0.0368,6387,0.797,"RPL37A, RPS4X, FAU, RPL24, RSL24D1, RPL23, RPS5, RPS19, RPL27, RPS15, RPL3, RPL21, RPS17, RPL29, RPL15, RPL23A, RPS8, RPL35, RPS3A, RPL30, RPS13, RPL35A, RPL8, RPL27A, RPL5, RPL32, RPS3, RPL18, RPL36A, RPL36AL, RPS9, RPL18A, RPS15A, RPS25, RPS7, RPL26, RPL38, RPL28, RPL6, RPS24, RPL22, RPL34, RPL17, RPS2, RPL11, RPL9, RPS18, RPL13A, RPL4, RPL31, RPS16, RPS29, RPS20, RPL19, RPL10A, RPS6, RPL14, RPS11, RPL37, RPL7A, RPS23, RPL7, UBA52, RPL36, RPS27L, RPS4Y1",1.43415218132648,0.0985416786038876,FALSE
+"H3255","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.21217,0.65,0.909,741,0.954,"MAPK12, IRF7, MAPK13, DDX58, CASP10",0.0414361167780325,0.0204516252959049,FALSE
+"H3255","Input","KEGG_RNA_DEGRADATION",-0.35406,-1.07,0.333,6817,0.814,"CNOT4, CNOT9, PARN, DCP1A, CNOT7, EXOSC5, CNOT2, PAPOLG, EXOSC10, CNOT1, EXOSC3, DDX6, MTREX, ENO3, XRN1, CNOT6L, PATL1, EDC3, MPHOSPH6, CNOT6, DIS3, DCPS, C1D",0.47755576649368,0.0893755951107988,FALSE
+"H3255","Input","KEGG_RNA_POLYMERASE",-0.19527,-0.594,0.964,1932,1,"POLR2J, POLR3GL, POLR1E, POLR3G, POLR2D, POLR2G, POLR2I, POLR2F, POLR2E, POLR2C, POLR2K, POLR2L, POLR2H, POLR1B, POLR1A, POLR2A, POLR3C, POLR1C, POLR1D, POLR2B, POLR3D, POLR3F, POLR3K, POLR3H, POLR3A, POLR3B",0.0159229660971692,0,FALSE
+"H3255","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.43698,1.32,0.135,1288,0.555,"GGT5, GGT1, PAPSS2, TRMT11, CTH",0.869666231504994,0.255707016877324,FALSE
+"H3255","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.34335,-1.03,0.381,9225,0.802,"BIRC2, ITGB1, LAMA3, LAMA4, COL4A1, COL4A6, ITGA6, COL4A2, TP53",0.419075024324381,0.0958256317158365,FALSE
+"H3255","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.41183,1.24,0.211,1992,0.514,"VTI1B, GOSR2, STX16, STX8, BET1L, GOSR1, STX17, VAMP4, STX6, VAMP8, TSNARE1",0.675717544702307,0.289036881004724,FALSE
+"H3255","Input","KEGG_SPHINGOLIPID_METABOLISM",0.48964,1.52,0.084,908,0.404,"GALC, NEU1, ASAH1, ARSA, SMPD1, SGPP1, PLPP1, PLPP2",1.07572071393812,0.393618634889395,FALSE
+"H3255","Input","KEGG_SPLICEOSOME",0.32927,0.99,0.433,3991,0.754,"HSPA6, ISY1, SRSF9, SF3B5, NCBP2, DDX42, DDX23, SRSF5, PRPF19, PRPF40A, SF3A1, TRA2A, SNRPG, PQBP1, HSPA1A, BCAS2, LSM2, PPIL1, HNRNPA1, CDC5L, SRSF8, SNRPB2, CDC40, SYF2, PPIE, PHF5A, PLRG1, SART1, WBP11, U2AF1, SRSF2, SRSF4, CCDC12, SNRNP200, LSM8, ACIN1, TRA2B, SNRPF, SRSF3, SNW1, HNRNPA3, SRSF1, TXNL4A, SRSF7, HSPA1L, SNRNP40, RBM8A, RBMX, PRPF6, HNRNPM, SNRPB, DDX5, EFTUD2, SF3B2, U2AF2, THOC3, RBM17, LSM7, HNRNPK, SNRPA1, SF3B3, XAB2, LSM6, SF3A3",0.363512103646635,0.122628654130226,FALSE
+"H3255","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.4374,1.32,0.146,258,0.555,"ENPP3, GUSB",0.835647144215563,0.255707016877324,FALSE
+"H3255","Input","KEGG_STEROID_BIOSYNTHESIS",0.63439,1.97,0.0081,2032,0.229,"DHCR24, DHCR7, LSS, TM7SF2, FDFT1, CYP27B1, CYP51A1, SOAT2, MSMO1, SC5D",2.09151498112135,0.640164517660112,TRUE
+"H3255","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.49854,1.53,0.064,1835,0.421,"SULT2B1, AKR1D1, SRD5A3, HSD11B2, STS, HSD17B12, COMT, AKR1C3, HSD17B8, CYP3A4, AKR1C1",1.19382002601611,0.375717904164332,FALSE
+"H3255","Input","KEGG_SULFUR_METABOLISM",0.53852,1.66,0.0538,707,0.34,"SULT2B1, SUOX, PAPSS2",1.26921772433361,0.468521082957745,FALSE
+"H3255","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.57395,-1.74,0.0405,9353,0.596,"C1S, TRIM21, C3, CD40",1.39254497678533,0.224753740259764,FALSE
+"H3255","Input","KEGG_TASTE_TRANSDUCTION",0.26359,0.798,0.694,3980,0.913,"ITPR3, GNB3, GNAS, ADCY6, PRKACA, CACNA1A",0.158640529545145,0.039529222465701,FALSE
+"H3255","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",0.42654,1.33,0.151,1331,0.597,"PDSS2, HMGCS1, HMGCR, ACAT2",0.821023052706831,0.224025668870631,FALSE
+"H3255","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.28957,-0.877,0.578,6712,0.815,"SMAD1, E2F4, SKP1, SMAD5, SMAD4, TGFBR1, AMH, MAPK3, MYC, SMAD2, CUL1, BMPR2, SP1, ID1, INHBA, PPP2R1B, SMAD9, TFDP1, BMPR1A, TGFB2",0.238072161579471,0.0888423912600234,FALSE
+"H3255","Input","KEGG_THYROID_CANCER",-0.34566,-1.05,0.347,8378,0.805,"PPARG, TFG, PAX8, MAP2K1, LEF1, TP53",0.459670525209126,0.0942041196321315,FALSE
+"H3255","Input","KEGG_TIGHT_JUNCTION",0.24142,0.733,0.82,2180,0.933,"CLDN3, PATJ, CRB3, EPB41L3, PRKCH, AFDN, CTNNB1, CGN, OCLN, CLDN4, TJP3, MYH2, MPDZ, MAGI3, PARD6A, MYH7, MYH3, CTNNA1, TJP2, HRAS, PRKCI, PARD6G, AKT1",0.0861861476162833,0.0301183562535,FALSE
+"H3255","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.25273,0.753,0.772,558,0.956,"LY96, MYD88, MAPK12, TLR2, IRF7, TOLLIP, MAPK13",0.112382699664264,0.0195421077238999,FALSE
+"H3255","Input","KEGG_TRYPTOPHAN_METABOLISM",0.31548,0.961,0.433,1824,0.783,"ALDH2, GCDH, ALDH3A2, MAOA, OGDHL, ACAT2, OGDH, EHHADH",0.363512103646635,0.106238237942057,FALSE
+"H3255","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.50204,-1.55,0.0599,9126,0.733,"PKM, MAPK8, PKLR, MAPK10, SOCS4, IRS2",1.22257317761069,0.134896025358872,FALSE
+"H3255","Input","KEGG_TYROSINE_METABOLISM",-0.43489,-1.34,0.126,6964,0.716,"MIF, TAT, ADH5, ADH1C, METTL2B, GOT2, DCT, LCMT1, MAOB, ALDH3B1, ALDH1A3, HGD, LCMT2, ALDH3A1",0.899629454882437,0.145086977692144,FALSE
+"H3255","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.28586,-0.845,0.631,8086,0.829,"PAK2, PAK3, FYN, CBLB, NCK1, SOS1, PIK3CB, LAT, PPP3CC, LCK, NCK2, MAP2K7, BCL10, MAP2K1, RAF1, NFATC1, CARD11, MALT1, PRKCQ, NFAT5, CBL",0.199970640755866,0.0814454694497265,FALSE
+"H3255","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.27742,-0.837,0.64,7165,0.814,"SIAH1, UBE2K, NEDD4, UBE2M, UBE2B, RNF7, UBA3, MID1, CUL2, CUL1, COP1, HERC3, XIAP, UBE4B, UBE4A, KEAP1, CBLB, CUL4A, VHL, WWP1, UBE2F, CDC26, UBE2Q1, UBE2E2, UBA1, UBE2D2, CUL4B, CUL5, HUWE1, BIRC2, PML, HERC4, UBE2E1, UBA7, CBL, FBXO2",0.193820026016113,0.0893755951107988,FALSE
+"H3255","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.27274,-0.834,0.648,5944,0.81,"PDHB, VARS2, PDHA1, LARS2",0.188424994129407,0.0915149811213502,FALSE
+"H3255","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.5036,1.54,0.0789,1996,0.438,"ACAD8, OXCT1, ALDH2, ALDH6A1, HMGCS1, ACAA1, IVD, BCKDHA, ALDH3A2, HIBADH, BCKDHB, ACAT2, BCAT2, ACADSB, EHHADH, HIBCH, PCCA",1.10292299679058,0.3585258894959,FALSE
+"H3255","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.28456,-0.879,0.586,8757,0.821,"PLCB4, MAP2K1, RAF1, ARAF, MYLK, CACNA1F, PRKCQ, CALD1, PLA2G6",0.232102383981909,0.0856568428805592,FALSE
+"H3255","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.1831,-0.548,0.99,6922,1,"DYNLL2, DYNC1LI1, ADCY3, DYNC1H1, VAMP2, ADCY9, DCTN5, DYNC2LI1, DCTN2, STX4, RAB11A, DCTN4, DCTN1, CREB5",0.00436480540245009,0,FALSE
+"H3255","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.23102,0.698,0.864,1254,0.947,"PTGS2, PLA2G4A, MAPK12, MAPK13, PLA2G12A, VEGFA, PPP3R1, BAD",0.0634862575211067,0.0236500209967266,FALSE
+"H3255","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.22932,0.69,0.868,3387,0.919,"PDIA4, ERO1A, KDELR1, SLC12A2, ATP6V1F, TJP2, ATP6AP1, GNAS, TJP1, ATP6V1G1, ATP6V1B1, ATP6V1E1, ATP6V1B2, ATP6V0A1, ACTB",0.0614802748235081,0.0366844886138887,FALSE
+"H3255","Input","KEGG_VIRAL_MYOCARDITIS",0.22327,0.692,0.855,499,0.929,"ICAM1, CCND1, CD55",0.0680338852718274,0.0319842860063582,FALSE
+"H3255","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.3,-0.89,0.558,7165,0.845,"SIAH1, CSNK2A1, CSNK2A2, MYC, CHP1, PPP2R5A, NFATC3, SMAD2, PLCB2, RAC3, CUL1, CACYBP, VANGL1, PPP2R5D, AXIN2, FZD2, PPP3CC, PORCN, RAC2, PLCB4, NLK, PPP2R1B, MMP7, NFATC1, CSNK1E, MAPK8, LEF1, MAPK10, SOX17, FZD7, WNT10A, FOSL1, NFAT5, WNT7A, TP53",0.253365801062421,0.0731432910503077,FALSE
+"H358","Input","KEGG_ABC_TRANSPORTERS",-0.6212,-1.91,0.0143,7484,0.183,"ABCB4, ABCB7, ABCB6, ABCC5, ABCA1, ABCD1, ABCC3, ABCC6, ABCB1, ABCA3, ABCB10, ABCB8, ABCC2, ABCB11",1.84466396253494,0.737548910269571,TRUE
+"H358","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",0.22332,0.687,0.845,1293,0.895,"PIK3R3, PIK3CD, RPS6KB2, RUNX1, CCND1, KRAS, NRAS, RPS6KB1, PIK3CA",0.0731432910503077,0.048176964684088,FALSE
+"H358","Input","KEGG_ADHERENS_JUNCTION",0.44542,1.33,0.134,1897,0.515,"RAC2, CDH1, CTNNA1, CTNND1, CTNNB1, CTNNA2, BAIAP2, LMO7, PTPRF, NECTIN4, ERBB2, SMAD3, RAC3, FARP2, MET, CSNK2A1, CSNK2A2, TJP1, PTPRJ, IGF1R, EP300, CREBBP, CSNK2B, ACTN4, NECTIN3, CDC42, YES1, PTPRB",0.872895201635192,0.288192770958809,FALSE
+"H358","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.37773,1.17,0.243,940,0.499,"IRS1, SLC2A1, RXRA, MAPK10, MAPK9, RXRG, ADIPOR1, RXRB",0.614393726401688,0.30189945437661,FALSE
+"H358","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.64866,-1.99,0.00567,8106,0.198,"ASNS, GPT, AGXT, ALDH5A1, GLS, GLS2, CPS1, GOT1, ALDH4A1, ASS1, ABAT, NIT2",2.24641694110709,0.703334809738469,TRUE
+"H358","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.43781,1.37,0.116,409,0.624,"IRS1, SLC9A3R2, PIK3R3, SCNN1B, ATP1B1, PIK3CD",0.935542010773082,0.204815410317576,FALSE
+"H358","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",0.6165,1.9,0.0172,974,0.488,"PLA2G4A, PLA2G12A",1.76447155309245,0.311580177997289,FALSE
+"H358","Input","KEGG_ALZHEIMERS_DISEASE",-0.30126,-0.926,0.515,6143,0.683,"MAPK3, ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ERN1, LRP1, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, GRIN1, NDUFA10, ATP5F1D, GNAQ, COX7A2L, GSK3B, NDUFA7, NDUFB2, COX6B1, MAPK1, ATP5F1B, CASP9, NDUFS6, NDUFV2, BID, ATP5PD, NDUFS3, ITPR3, APOE, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, GAPDH, APAF1, NDUFA5, UQCRC1, CDK5, PPP3CC, ATP5MC2, UQCRFS1, IDE, ITPR1, UQCRC2, ITPR2, SNCA, MAPT",0.288192770958809,0.165579296318467,FALSE
+"H358","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.3828,-1.2,0.221,5801,0.387,"FARSA, NARS2, VARS2, FARSB, AARS2, TARS2, DARS2, CARS2, EARS2, RARS2",0.655607726314889,0.412289034981089,FALSE
+"H358","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.45595,-1.41,0.0939,6602,0.314,"UGP2, NAGK, GMPPA, GCK, MPI, GNE, GFPT1, HEXA, CYB5R3, NANS, PMM1, GNPDA1, GPI, UAP1, CYB5R1, RENBP, GALK1, CMAS, UXS1, PGM3, HEXB",1.02733440773389,0.503070351926785,FALSE
+"H358","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.43894,-1.36,0.125,7699,0.323,"CYCS, APAF1, CASP1, CAT, MAPK12, MAPK11, BAX, CCS, PPP3CC, SOD1, NEFL, NEFM, TP53, PRPH, PRPH2, NEFH",0.903089986991944,0.490797477668897,FALSE
+"H358","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.19338,0.593,0.969,2816,0.977,"PSME1, PSME2, B2M, HSPA2, PSME3, NFYC, NFYB, CREB1, HSPA1A, HSP90AB1, TAPBP, HSP90AA1, TAP1",0.0136762229492347,0.0101054362812269,FALSE
+"H358","Input","KEGG_APOPTOSIS",0.24267,0.763,0.759,1584,0.821,"PIK3R3, TNFRSF10A, PIK3CD, CAPN2, PPP3CA, CASP6, PPP3R2, ENDOD1, PPP3R1, ENDOG, PIK3CA, FAS, CHP1, CAPN1, BAD",0.11975822410452,0.0856568428805592,FALSE
+"H358","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.38862,-1.22,0.227,7465,0.369,"GPX4, TBXAS1, GGT7, GGT1, GPX2, CBR3, CBR1, GPX6, GPX7, AKR1C3, ALOX5",0.643974142806877,0.43297363384094,FALSE
+"H358","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.43376,-1.35,0.137,8508,0.318,"AGMAT, GLS, GLS2, CPS1, CKMT2, GOT1, SAT1, ALDH4A1, MAOB, ASS1, ALDH2, ARG2, CKMT1A",0.863279432843593,0.497572880015567,FALSE
+"H358","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.30731,0.941,0.482,1649,0.735,"ITGB6, ITGB4, ITGA3, CTNNA1, LMNA, CTNNB1, CTNNA2, DSC2, DAG1, ITGB5, ITGA6, ATP2A2, DMD, DSG2, ITGA2, ACTN4",0.31695296176115,0.133712660915805,FALSE
+"H358","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.37767,-1.17,0.231,7819,0.413,"ALDH7A1, ALDH2",0.636388020107856,0.384049948343599,FALSE
+"H358","Input","KEGG_AXON_GUIDANCE",0.41139,1.29,0.161,1123,0.535,"RAC2, EPHA2, SEMA7A, EPHB2, SEMA3A, EPHA6, SEMA4B, EPHA1, RASA1, EPHB3, PPP3CA, EPHA5, EPHA4, SEMA4C, RAC3, NRP1, NGEF, PPP3R2, MET, KRAS, NRAS, EFNB2, PPP3R1",0.79317412396815,0.271646217978772,FALSE
+"H358","Input","KEGG_BASAL_CELL_CARCINOMA",-0.49233,-1.52,0.0788,6906,0.242,"GSK3B, FZD7, FZD1, DVL3, DVL2, STK36, TCF7L2, LEF1, WNT16, TP53, WNT11",1.10347378251044,0.616184634019569,FALSE
+"H358","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.32691,1.02,0.366,3472,0.645,"GTF2E2, TAF9B, GTF2B, TAF6L, TAF1, GTF2E1, GTF2IRD1, GTF2I, TAF5L, TAF5, GTF2F1, TAF6, TAF4, TAF2, GTF2A1",0.436518914605589,0.190440285364732,FALSE
+"H358","Input","KEGG_BASE_EXCISION_REPAIR",0.59343,1.84,0.0215,2035,0.375,"TDG, PCNA, POLD3, PARP2, NEIL2, UNG, FEN1, POLD1, LIG1, POLE3, MUTYH, APEX1, POLD2, APEX2, POLE2, POLB",1.66756154008439,0.425968732272281,FALSE
+"H358","Input","KEGG_BETA_ALANINE_METABOLISM",-0.58564,-1.81,0.0165,6587,0.19,"SRM, ECHS1, ALDH1B1, ACADM, DPYD, MLYCD, ALDH7A1, EHHADH, ALDH2, ABAT",1.78251605578609,0.721246399047171,TRUE
+"H358","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.29329,0.902,0.564,1225,0.748,"HACD1, ELOVL5, ELOVL6, FADS1",0.248720896016658,0.126098402135539,FALSE
+"H358","Input","KEGG_BLADDER_CANCER",0.36401,1.1,0.322,1089,0.54,"CDH1, THBS1, RB1, CCND1, ERBB2, KRAS, NRAS",0.492144128304169,0.267606240177031,FALSE
+"H358","Input","KEGG_BUTANOATE_METABOLISM",-0.51511,-1.57,0.0551,7819,0.224,"ALDH7A1, ACADS, HMGCS1, AKR1B10, ACAT2, ALDH5A1, EHHADH, HMGCS2, ALDH2, ABAT",1.25884840114821,0.649751981665837,FALSE
+"H358","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",0.31463,0.945,0.478,1362,0.742,"RAC2, PIK3R3, LYN, PIK3CD, PPP3CA, RAC3, PPP3R2, KRAS, NRAS, PPP3R1, PIK3CA, CHP1",0.320572103387881,0.129596094720973,FALSE
+"H358","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2962,0.913,0.494,1857,0.78,"TNNC1, TNNC2, LTB4R2, PPP3CA, ERBB2, PLCB1, PTK2B, MYLK, PPP3R2, HRH1, CAMK2D, CACNA1A, PPP3R1, CAMK2G, CHP1, ERBB3, PRKCG, ATP2A2, ERBB4, PHKB, PPP3CB, ATP2B1, PHKA1",0.306273051076353,0.10790539730952,FALSE
+"H358","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.29258,0.901,0.549,1505,0.738,"TNNC1, ATP1B1, SLC9A6, CYC1, SLC9A1, MYL3, UQCR10, ATP2A2",0.260427655549908,0.131943638176958,FALSE
+"H358","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.46036,1.41,0.129,602,0.725,"CLDN7, CDH15, CDH3, ITGB2, CLDN4, SDC4, SDC1, CDH1, CD274, F11R, CNTN1, CLDN3, PTPRF, CD276, SDC2",0.889410289700751,0.139661993429006,FALSE
+"H358","Input","KEGG_CELL_CYCLE",0.4905,1.49,0.0972,1942,0.735,"FZR1, CDC20, CCNA2, MCM4, MCM7, ORC6, CHEK1, MCM5, MCM6, MCM3, BUB1, PCNA, CCNB1, RB1, PLK1, CCND1, CCNB2, SMAD3, MAD2L1, MCM2, SKP2, RBL1, BUB1B, TGFB2, CDC45, CDK1, CDK2, YWHAZ, CDC7, EP300, STAG2, CREBBP, RAD21, SMC3, SFN, CDC6, ESPL1, TTK, TFDP1, SMC1A, BUB3, ORC4, RBX1, PRKDC, YWHAQ, SMC1B",1.01233373507373,0.133712660915805,FALSE
+"H358","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.26252,0.802,0.699,1326,0.796,"RAC2, PIK3R3, HCK, LYN, PIK3CD, GNG10, GRK2, PLCB1, PTK2B, GNG5, KRAS, NRAS, PRKCD, BCAR1, PIK3CA, PRKCZ",0.155522824254319,0.0990869322623309,FALSE
+"H358","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.22527,-0.716,0.851,8017,0.91,"PIK3R1, CRKL, TGFB1, TGFB3, MAP2K2, CDKN2A, PIK3CB, CDKN1B, CRK, SOS1, TP53",0.0700704399154121,0.0409586076789064,FALSE
+"H358","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.40871,-1.24,0.188,7527,0.352,"OGDH, PC, IDH1, OGDHL, ACO2, IDH2, PCK2",0.72584215073632,0.453457336521869,FALSE
+"H358","Input","KEGG_COLORECTAL_CANCER",0.36981,1.15,0.271,1702,0.505,"RAC2, PIK3R3, CTNNB1, PIK3CD, MAPK10, MAPK9, CCND1, MSH6, SMAD3, MSH2, RAC3, TGFB2, KRAS, PIK3CA, MLH1, BAD, MSH3",0.567030709125594,0.296708621881339,FALSE
+"H358","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.45796,-1.41,0.112,7947,0.314,"CFD, C3, FGB, PROS1, SERPIND1, SERPINE1, THBD, C5, F5, SERPINA1, C4A, SERPINF2, C9, SERPING1, A2M, PLG",0.950781977329818,0.503070351926785,FALSE
+"H358","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.19193,-0.6,0.952,6360,0.972,"MAT2B, MTR, SRM, MTAP, SDS, APIP, MPST, ADI1, GOT1, CDO1",0.0213630516155257,0.0123337350737254,FALSE
+"H358","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.35815,-1.08,0.324,7654,0.505,"IFNGR1, KIT, LEPR, IL17RA, CSF2RA, TGFB1, OSM, TGFB3, CD70, IL25, HGF, NGFR, IFNAR2, INHBE, IL6",0.489454989793388,0.296708621881339,FALSE
+"H358","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.32932,-1.02,0.384,9147,0.539,"ZBP1, PYCARD, IL6",0.415668775632469,0.268411234813261,FALSE
+"H358","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.31951,-0.972,0.447,8449,0.615,"SGCB, TGFB3, ITGB8, TPM2, ITGB3, ACTG1, SGCD, ITGA5, ITGA7, DES, ITGA4",0.349692476868064,0.211124884224583,FALSE
+"H358","Input","KEGG_DNA_REPLICATION",0.71474,2.21,0.00615,1339,0.289,"MCM4, MCM7, POLA1, PRIM1, MCM5, MCM6, MCM3, PRIM2, PCNA, POLD3, RFC3, FEN1, POLD1, LIG1, MCM2, RFC4, POLA2, RFC5, POLE3, RFC2, RNASEH2A, DNA2, RNASEH2B, POLD2",2.21112488422458,0.539102157243452,FALSE
+"H358","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.41391,1.25,0.196,1088,0.505,"NOTCH3, ETS1, KRAS",0.707743928643524,0.296708621881339,FALSE
+"H358","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.44433,-1.38,0.107,8249,0.338,"GSTO1, CYP3A5, MGST3, GSTK1, MAOB, GSTM3, GSTM1, GSTM2, GSTM4",0.97061622231479,0.471083299722345,FALSE
+"H358","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.29305,-0.908,0.539,8083,0.708,"GUSB, CYP3A5, CES1, CES2, UMPS, TPMT, NAT2",0.268411234813261,0.149966742310231,FALSE
+"H358","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.37486,1.14,0.268,273,0.497,"ITGB6, LAMC2, TNC, ITGB4, SDC4, SDC1, ITGA3, LAMB3, LAMA5, AGRN, THBS1",0.571865205971211,0.303643611266668,FALSE
+"H358","Input","KEGG_ENDOCYTOSIS",-0.2565,-0.786,0.715,6243,0.849,"AP2M1, SH3GL1, RNF41, IQSEC1, ACAP3, CHMP4A, CHMP4B, CLTB, RAB4A, PDCD6IP, EPN1, RAB5B, RBSN, SRC, AP2S1, PIP4K2B, RAB11FIP5, CBLB, EHD3, VPS36, STAM2, VTA1, PARD6G, VPS37C, HGS, PARD3, ARRB1, ASAP3, VPS4B, EPS15, PIP5K1C, CHMP3, PARD6B, DAB2, ARFGAP2, TRAF6, KIT, EEA1, PIKFYVE, ACAP2, VPS25, FGFR3, PRKCI, FGFR4, SNF8, ARFGAP1, ARFGAP3, CHMP5, DNM1L, ARRB2, ASAP2, DNM2, PLD1, GIT2, AP2A2, RABEP1, VPS37A, STAM, SH3GL2",0.145693958198919,0.0710923097560473,FALSE
+"H358","Input","KEGG_ENDOMETRIAL_CANCER",0.34581,1.07,0.314,1584,0.567,"CDH1, CTNNA1, PIK3R3, CTNNB1, CTNNA2, PIK3CD, CCND1, ERBB2, PTEN, KRAS, NRAS, PIK3CA, MLH1, BAD",0.503070351926785,0.246416941107093,FALSE
+"H358","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.23559,0.718,0.808,981,0.873,"MAPK13, F11R, LYN, MAPK10, MAPK9, MET, TJP1",0.0925886392254138,0.0589857562944303,FALSE
+"H358","Input","KEGG_ERBB_SIGNALING_PATHWAY",0.38844,1.16,0.272,1584,0.501,"EREG, AREG, PIK3R3, PIK3CD, MAPK10, RPS6KB2, MAPK9, ERBB2, CAMK2D, KRAS, NRAS, RPS6KB1, MAP2K4, CAMK2G, PIK3CA, ERBB3, PRKCG, ERBB4, BAD",0.565431095965801,0.300162274132754,FALSE
+"H358","Input","KEGG_ETHER_LIPID_METABOLISM",0.48928,1.52,0.0742,974,0.852,"LPCAT2, LPCAT4, PLPP2, LPCAT1, PLA2G4A, PLA2G12A",1.12959609472097,0.0695604052332999,FALSE
+"H358","Input","KEGG_FATTY_ACID_METABOLISM",-0.40144,-1.25,0.186,7739,0.346,"ECI2, ALDH7A1, ACADS, ACAT2, ACSL5, EHHADH, GCDH, ALDH2, ACADSB, ACAA2",0.730487055782084,0.460923901207223,FALSE
+"H358","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",0.44116,1.37,0.135,1293,0.624,"MAPK13, RAC2, PIK3R3, LYN, PIK3CD, MAPK10, MAPK9, PLA2G4A, RAC3, PLA2G12A, KRAS, NRAS, PRKCD, MAP2K4, PIK3CA",0.869666231504994,0.204815410317576,FALSE
+"H358","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",0.27061,0.848,0.629,685,0.756,"RAC2, PIK3R3, HCK, LYN, PLPP2, PIK3CD, RPS6KB2, PLA2G4A, MARCKSL1, SCIN",0.201349354554731,0.121478204498793,FALSE
+"H358","Input","KEGG_FOCAL_ADHESION",0.27438,0.865,0.6,663,0.772,"RAC2, ITGB6, LAMC2, TNC, ITGB4, CAV1, ITGA3, CAV2, LAMB3, LAMA5, THBS1, PIK3R3, CTNNB1, PIK3CD, MAPK10, MAPK9, CAPN2, CCND1, ERBB2, PTEN",0.221848749616356,0.112382699664264,FALSE
+"H358","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.56123,-1.72,0.0325,7518,0.196,"ALPG, QDPR, SPR, GGH",1.48811663902113,0.707743928643524,TRUE
+"H358","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.26697,-0.815,0.662,6206,0.803,"PMM2, PFKP, TPI1, GMPPA, PFKM, MPI, PMM1, PFKL, MTMR6, AKR1B10, PHPT1, AKR1B1",0.1791420105603,0.095284454721319,FALSE
+"H358","Input","KEGG_GALACTOSE_METABOLISM",-0.27798,-0.863,0.6,5799,0.767,"GALT, GLA, GANC, PFKP, UGP2, GLB1, GCK, PFKM, PFKL, GALK1, AKR1B1",0.221848749616356,0.115204636051019,FALSE
+"H358","Input","KEGG_GAP_JUNCTION",-0.29563,-0.891,0.541,6333,0.722,"PRKACB, GUCY1B1, GNA11, TUBA1C, TUBA1B, TUBB1, GNAI1, RAF1, TUBB, TUBA3C, SRC, GNAQ, TUBB2A, MAPK7, MAPK1, ITPR3, GRM5, TUBB6, GUCY1A1, TUBB2B, MAP2K2, GJA1, ITPR1, TUBB4A, ITPR2, SOS1",0.266802734893431,0.141462802430361,FALSE
+"H358","Input","KEGG_GLIOMA",0.28779,0.881,0.578,1461,0.751,"PIK3R3, PIK3CD, RB1, CCND1, PTEN, CAMK2D, KRAS, NRAS, IGF1R, CAMK2G, PIK3CA, PRKCG",0.238072161579471,0.124360062995832,FALSE
+"H358","Input","KEGG_GLUTATHIONE_METABOLISM",-0.53235,-1.61,0.0543,7465,0.217,"GPX4, GGT7, GSTP1, GSTA4, GGCT, IDH1, GGT1, GPX2, GSTO1, RRM2B, MGST3, ANPEP, IDH2, GPX6, GPX7, GSTK1, TXNDC12, GSTM3, GSTM1, GSTM2, GSTM4",1.26520017041115,0.66354026615147,FALSE
+"H358","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.33778,-1.05,0.355,8822,0.514,"PLPP1, GK, AKR1B1, AKR1A1, ALDH2, AGPAT3",0.449771646944906,0.289036881004724,FALSE
+"H358","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.32143,1.01,0.382,554,0.637,"LPCAT2, LPCAT4, MBOAT2, PLPP2, LPCAT1, CHKB, MBOAT1, PLA2G4A, GPAT3",0.417936637088291,0.19586056766465,FALSE
+"H358","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.45088,-1.37,0.13,8322,0.322,"AGXT, PSPH, GCAT, SARDH, PSAT1, MAOB, GLDC",0.886056647693163,0.492144128304169,FALSE
+"H358","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.23074,0.693,0.828,1568,0.898,"ALDH1A3, ADH4, ADH7, PKM, PGM2, PKLR, ENO1, ENO3, ALDH3A2, ALDH3B1",0.0819696632151199,0.0467236633326956,FALSE
+"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.56934,-1.75,0.0208,7600,0.199,"XYLT2, CHST13, CSGALNACT2, CHST12, B4GALT7, XYLT1, CHST3, CHST11",1.68193666503724,0.701146923590293,TRUE
+"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35211,-1.08,0.34,7600,0.505,"XYLT2, NDST1, EXTL2, B4GALT7, XYLT1",0.468521082957745,0.296708621881339,FALSE
+"H358","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.43658,-1.35,0.137,8711,0.318,"B4GALT4, ST3GAL1",0.863279432843593,0.497572880015567,FALSE
+"H358","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.36731,-1.15,0.252,8073,0.433,"HGSNAT, GUSB, IDUA, GNS, HEXB, ARSB",0.598599459218456,0.363512103646635,FALSE
+"H358","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.68557,-2.13,0.00573,8603,0.156,"NAGA, HEXB, ST3GAL1",2.24184537803261,0.806875401645538,TRUE
+"H358","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.47613,-1.48,0.0696,8711,0.271,"B4GALT4, FUT4, ST3GAL6",1.15739076038944,0.567030709125594,FALSE
+"H358","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.37327,1.17,0.249,1236,0.499,"PIGG, PIGW, PIGK, PIGS, PIGT",0.603800652904264,0.30189945437661,FALSE
+"H358","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.43064,-1.34,0.118,8167,0.312,"GRHPR, ACO2, PGP",0.928117992693875,0.505845405981557,FALSE
+"H358","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28301,0.858,0.584,1216,0.761,"MAPK13, MAPK10, MAPK9, PLA2G4A, PLCB1, PTK2B, PLA2G12A, CAMK2D, KRAS, NRAS, PRKCD, MAP2K4, CAMK2G",0.233587152887601,0.118615343229427,FALSE
+"H358","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.33321,-1.04,0.347,8928,0.522,"WNT16, WNT11",0.459670525209126,0.282329496997738,FALSE
+"H358","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.41356,-1.27,0.187,7735,0.337,"KIT, ITGA1, CSF2RA, ANPEP, ITGB3, CD7, ITGA5, ITGA4, IL6",0.728158393463501,0.472370099128661,FALSE
+"H358","Input","KEGG_HISTIDINE_METABOLISM",-0.34815,-1.07,0.32,7312,0.505,"TRMT11, AOC1, ALDH7A1, HNMT, LCMT1, MAOB, DDC, ALDH2",0.494850021680094,0.296708621881339,FALSE
+"H358","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.41437,1.25,0.19,2231,0.505,"POLD3, RAD54B, POLD1, RAD51C, EME1, RAD54L, POLD2, RPA3, BLM, RPA2, TOP3A, RPA1",0.721246399047171,0.296708621881339,FALSE
+"H358","Input","KEGG_HUNTINGTONS_DISEASE",-0.33169,-1.02,0.389,6162,0.539,"ATP5PO, NDUFS7, NDUFB6, TFAM, ATP5PF, NDUFV1, AP2M1, COX6A1, NDUFS2, CLTB, NDUFB10, CREB5, ATP5F1E, NDUFV3, DNAL1, NDUFA8, NDUFS4, ATP5PB, GRIN1, NDUFA10, VDAC2, ATP5F1D, AP2S1, CREB3L2, GNAQ, COX7A2L, NDUFA7, NDUFB2, COX6B1, VDAC1, ATP5F1B, CASP9, POLR2I, DCTN4, NDUFS6, NDUFV2, ATP5PD, NDUFS3, IFT57, DNAH2, GRM5, TGM2, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, APAF1, NDUFA5, HIP1, UQCRC1, DCTN1, BAX, AP2A2, ATP5MC2, UQCRFS1, SOD1, DCTN2, ITPR1, UQCRC2, SOD2, TP53",0.410050398674292,0.268411234813261,FALSE
+"H358","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.34436,-1.07,0.324,7794,0.505,"PRKAB2, ITGA1, CACNA2D2, ACE, TGFB1, SGCB, TGFB3, ITGB8, TPM2, ITGB3, ACTG1, SGCD, ITGA5, ITGA7, DES, ITGA4, IL6",0.489454989793388,0.296708621881339,FALSE
+"H358","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.27896,-0.854,0.614,6782,0.766,"PIP4K2A, PIP4K2B, PIK3C2A, SYNJ1, PIK3C2B, OCRL, PIP5K1C, PLCG1, PIK3C3, INPP5K, PIKFYVE, PLCG2, ITPKA, IMPA1, MINPP1, ITPK1, PIK3CB, ITPKB",0.211831628858832,0.115771230367396,FALSE
+"H358","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.19998,-0.616,0.943,6207,0.97,"RPTOR, TSC2, PRKAA1, PRKAR2A, MAPK8, PRKACB, PRKAA2, FLOT2, AKT3, PRKAG2, RAF1, PRKAR1A, GCK, CBLB, GSK3B, PIK3R2, RAPGEF1, MAPK1, RHEB, SHC1, PRKAG1, PPP1R3D, TSC1, PRKAR1B, GYS1, INPP5D, PRKAR2B, PRKAB2, IRS2, INPP5K, PIK3R1, PRKCI, PPP1R3A, CRKL, INSR, MAP2K2, PIK3CB, PDE3B, CRK, SORBS1, PCK2, FOXO1, SOS1",0.0254883072626717,0.0132282657337552,FALSE
+"H358","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.68318,-2.11,0.00382,8209,0.131,"ICOSLG, TGFB1, ITGA4, IL6",2.41793663708829,0.882728704344236,TRUE
+"H358","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.27411,-0.847,0.642,7649,0.77,"TYK2, IFNGR1, LEPR, STAT5A, PIK3R1, CSF2RA, OSM, PIM1, STAT2, STAM, PIK3CB, PIAS2, SOS1, IFNAR2, IL6",0.192464971931147,0.113509274827518,FALSE
+"H358","Input","KEGG_LEISHMANIA_INFECTION",0.37631,1.18,0.225,52,0.539,"MAPK13, ITGB2, PTGS2",0.647817481888638,0.268411234813261,FALSE
+"H358","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.45698,1.41,0.133,409,0.725,"CLDN7, MAPK13, RAC2, ITGB2, CLDN4, F11R, CTNNA1, CTNND1, PIK3R3, CLDN3, CTNNB1, CTNNA2, PIK3CD",0.876148359032914,0.139661993429006,FALSE
+"H358","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.57323,-1.71,0.0452,6689,0.183,"ECHS1, ALDH1B1, ALDH7A1, EHHADH, ALDH2",1.34486156518862,0.737548910269571,TRUE
+"H358","Input","KEGG_LINOLEIC_ACID_METABOLISM",0.40407,1.24,0.182,974,0.503,"PLA2G4A, PLA2G12A",0.739928612014925,0.298432014944073,FALSE
+"H358","Input","KEGG_LONG_TERM_DEPRESSION",-0.22166,-0.679,0.894,8896,0.933,"ITPR1, ITPR2, PPP1R17",0.0486624812040823,0.0301183562535,FALSE
+"H358","Input","KEGG_LONG_TERM_POTENTIATION",0.2607,0.822,0.67,1461,0.794,"PPP3CA, PLCB1, PPP3R2, CAMK2D, RPS6KA1, KRAS, NRAS, PPP3R1, CAMK2G, EP300, CHP1, CREBBP, PRKCG",0.173925197299174,0.100179497572904,FALSE
+"H358","Input","KEGG_LYSINE_DEGRADATION",-0.34335,-1.05,0.379,7412,0.514,"PLOD1, AASS, OGDH, ALDH7A1, PLOD3, OGDHL, ACAT2, SETDB1, EHHADH, GCDH, ALDH2, TMLHE",0.421360790031928,0.289036881004724,FALSE
+"H358","Input","KEGG_LYSOSOME",-0.42291,-1.3,0.164,6514,0.316,"AP3D1, AP3S1, LAMP2, ENTPD4, GLB1, NEU1, ASAH1, AP3B1, PSAP, AP3M2, LAMP1, CLN5, ARSA, HEXA, GBA, ATP6V0D2, ATP6V0A2, CTSH, CTSA, AP3M1, ACP5, CTSK, CTSO, LIPA, GGA1, TPP1, ATP6V1H, NAPSA, ATP6V0A1, SUMF1, GGA2, CTSZ, HGSNAT, GUSB, AP3S2, IDUA, ACP2, DNASE2, AP1M1, NAGPA, PLA2G15, NAGA, GNS, PPT2, GM2A, IGF2R, CLN3, SMPD1, MAN2B1, HEXB, CD63, ARSB, SLC17A5",0.785156151952302,0.500312917381596,FALSE
+"H358","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.24673,-0.782,0.716,7883,0.846,"FLNC, MAP4K3, TAB1, MAPK8IP3, CACNA2D2, FGFR3, CRKL, MAP3K11, DUSP3, MAP3K7, FGFR4, MAPK12, TGFB1, RELB, ARRB2, MAPK11, TGFB3, MAP2K2, NFKB2, FGFR1, PPP3CC, TAOK3, CRK, DUSP9, RASA2, SOS1, TP53, FGF13, FGF2, STK4, MAPT",0.145086977692144,0.0726296369609765,FALSE
+"H358","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.6123,-1.91,0.0131,7830,0.183,"IAPP, HNF1B, PDX1, HNF1A, HNF4A, MNX1, PAX6, NEUROD1",1.88272870434424,0.737548910269571,TRUE
+"H358","Input","KEGG_MELANOGENESIS",-0.24352,-0.75,0.795,6685,0.894,"RAF1, CREB3L2, GNAQ, GSK3B, FZD7, MAPK1, MITF, ASIP, FZD1, TYRP1, DVL3, DVL2, KIT, TCF7L2, MAP2K2, LEF1, DCT, WNT16, WNT11",0.0996328713435297,0.0486624812040823,FALSE
+"H358","Input","KEGG_MELANOMA",-0.30676,-0.954,0.48,8517,0.639,"MAP2K2, CDKN2A, FGFR1, PIK3CB, HGF, TP53, FGF13, FGF2",0.318758762624413,0.1944991418416,FALSE
+"H358","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.53266,-1.68,0.038,8249,0.179,"GSTO1, CYP3A5, MGST3, GSTK1, AKR1C3, AKR1C1, GSTM3, GSTM1, GSTM2, GSTM4, AKR1C2",1.42021640338319,0.747146969020107,TRUE
+"H358","Input","KEGG_MISMATCH_REPAIR",0.69746,2.14,0.00851,2231,0.219,"PCNA, POLD3, MSH6, RFC3, POLD1, LIG1, MSH2, RFC4, RFC5, RFC2, POLD2, MLH1, RFC1, MSH3, RPA3, RPA2, RPA1",2.07007043991541,0.659555885159882,TRUE
+"H358","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.29271,0.89,0.523,1293,0.746,"CAB39, PIK3R3, PIK3CD, RPS6KB2, HIF1A, RPS6KA1, RPS6KB1, PIK3CA",0.281498311132726,0.127261172527331,FALSE
+"H358","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.43174,1.34,0.132,1461,0.523,"RAC2, ITGB2, LCK, RAET1L, ULBP2, PIK3R3, TNFRSF10A, PIK3CD, PPP3CA, RAC3, PTK2B, PPP3R2, KRAS, NRAS, PPP3R1, PIK3CA, FAS, CHP1, PRKCG",0.87942606879415,0.281498311132726,FALSE
+"H358","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.41402,-1.3,0.151,6579,0.316,"GRIN1, TSPO, PARD3, GRM5, LEPR, P2RX4, TACR1, PRSS3, PLG",0.821023052706831,0.500312917381596,FALSE
+"H358","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24965,0.78,0.729,1612,0.802,"MAPK13, IRS1, RPS6KA4, PIK3R3, PIK3CD, MAPK10, MAPK9, ARHGDIB, CAMK2D, RPS6KA1, KRAS, NRAS, PRKCD, CAMK2G, YWHAZ, KIDINS220, PIK3CA, BAD, FRS2, CSK, SORT1",0.137272471682025,0.0958256317158365,FALSE
+"H358","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.53954,-1.66,0.0455,8626,0.186,"ENPP1, NNMT, BST1, NMNAT3, QPRT",1.34198860334289,0.730487055782084,TRUE
+"H358","Input","KEGG_NITROGEN_METABOLISM",-0.63599,-1.94,0.00566,8024,0.212,"CA1, ASNS, CA8, GLS, GLS2, CPS1, CA12, CA2",2.24718356881173,0.673664139071249,TRUE
+"H358","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.23521,-0.723,0.839,7691,0.908,"TRAF6, TAB1, CASP1, MAP3K7, MAPK12, MAPK11, PYCARD, IL6",0.0762380391712997,0.0419141514789149,FALSE
+"H358","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.43034,1.35,0.143,851,0.591,"FEN1, XRCC5, XRCC6",0.844663962534938,0.228412519118745,FALSE
+"H358","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",0.26132,0.797,0.661,1584,0.782,"PIK3R3, RXRA, PIK3CD, RB1, CCND1, ERBB2, RXRG, RXRB, KRAS, NRAS, PIK3CA, PRKCG, BAD",0.17979854051436,0.106793246940152,FALSE
+"H358","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.45266,1.37,0.129,1722,0.624,"NOTCH3, JAG2, JAG1, NCOR2, RBPJ, CTBP1, EP300, CREBBP, KAT2A, DVL1",0.889410289700751,0.204815410317576,FALSE
+"H358","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.53415,1.64,0.0451,2231,0.662,"PCNA, POLD3, RFC3, POLD1, LIG1, RFC4, RFC5, POLE3, RFC2, CUL4A, POLD2, RFC1, DDB2, RBX1, RPA3, POLE2, RPA2, CUL4B, RPA1",1.34582345812204,0.1791420105603,FALSE
+"H358","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.2729,-0.844,0.601,7776,0.766,"ST6GAL1, MGAT4B, DPAGT1, MGAT3, MGAT1, MAN1A1, ALG11, MGAT5",0.22112552799726,0.115771230367396,FALSE
+"H358","Input","KEGG_OLFACTORY_TRANSDUCTION",0.35112,1.07,0.334,1818,0.567,"CAMK2D, CAMK2G, CNGB1",0.476253533188435,0.246416941107093,FALSE
+"H358","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.36155,-1.11,0.289,6496,0.474,"MTHFD2L, MTR, TYMS, GART, ALDH1L1, MTHFR",0.539102157243452,0.324221658325915,FALSE
+"H358","Input","KEGG_OOCYTE_MEIOSIS",0.38869,1.17,0.254,1993,0.499,"CDC20, AR, STAG3, BUB1, CCNB1, PLK1, PPP3CA, CCNB2, MAD2L1, AURKA, PPP3R2, BTRC, CAMK2D, CDK1, RPS6KA1, IGF1R, CDK2, PPP2CB, PPP3R1, CAMK2G, YWHAZ, PPP2R5C, CHP1, PPP2R5E, SMC3, ESPL1, PPP3CB, SMC1A, RBX1, YWHAQ, SMC1B, SGO1",0.595166283380062,0.30189945437661,FALSE
+"H358","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.41248,-1.28,0.162,6428,0.332,"MAN2C1, GLB1, NEU1, HEXA, GBA, MAN2B1, HEXB",0.790484985457369,0.478861916295964,FALSE
+"H358","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.43471,-1.31,0.13,6162,0.326,"ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ATP6V1C1, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, NDUFA10, ATP5F1D, COX7A2L, NDUFA7, NDUFB2, ATP6V1F, COX6B1, ATP5F1B, NDUFS6, ATP6V1D, ATP6V0D2, NDUFV2, ATP5PD, ATP6V0A2, NDUFS3, ATP5F1C, NDUFS8, UQCRB, ATP6V1C2, ATP5ME, ATP6V1A, ATP5F1A, ATP6V1H, ATP6V1B2, ATP6V1B1, NDUFA5, ATP6V0A1, ATP6V1E1, UQCRC1, COX15, ATP5MC2, UQCRFS1, COX11, UQCRC2, ATP6V1G1",0.886056647693163,0.486782399932061,FALSE
+"H358","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.58837,1.84,0.0271,634,0.375,"GALNT13, GALNT7, GALNT3, GALNT10, GALNT6, GALNT15",1.56703070912559,0.425968732272281,FALSE
+"H358","Input","KEGG_P53_SIGNALING_PATHWAY",0.39489,1.22,0.189,1324,0.489,"SERPINB5, THBS1, CHEK1, STEAP3, CCNB1, CCND1, CCNB2, EI24, RRM2, PTEN, CDK1, CDK2, GTSE1, FAS",0.723538195826756,0.31069114087638,FALSE
+"H358","Input","KEGG_PANCREATIC_CANCER",0.36209,1.1,0.303,1088,0.54,"RAC2, PIK3R3, PIK3CD, MAPK10, RB1, MAPK9, RALB, CCND1, ERBB2, SMAD3, RAC3, TGFB2, KRAS",0.518557371497695,0.267606240177031,FALSE
+"H358","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.6089,-1.89,0.0133,6783,0.16,"PANK3, DPYD, PPCS, PANK4, ENPP1, BCAT1",1.87614835903291,0.795880017344075,TRUE
+"H358","Input","KEGG_PARKINSONS_DISEASE",-0.4253,-1.33,0.155,6104,0.317,"SLC18A1, ATP5PO, NDUFS7, NDUFB6, ATP5PF, NDUFV1, COX6A1, NDUFS2, NDUFB10, ATP5F1E, NDUFV3, NDUFA8, NDUFS4, ATP5PB, NDUFA10, VDAC2, ATP5F1D, COX7A2L, NDUFA7, NDUFB2, COX6B1, VDAC1, ATP5F1B, CASP9, NDUFS6, NDUFV2, ATP5PD, NDUFS3, HTRA2, ATP5F1C, NDUFS8, UQCRB, CYCS, ATP5F1A, APAF1, NDUFA5, UQCRC1, UBE2L3, UBA7, UBE2G1, ATP5MC2, UQCRFS1, UBE2J1, UQCRC2, SNCA, UCHL1",0.809668301829709,0.498940737782249,FALSE
+"H358","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.21291,-0.669,0.895,6266,0.937,"ARPC5L, ARPC4, TUBA1C, ARHGEF2, TUBA1B, TUBB1, NCK1, ARPC2, TUBB, TUBA3C, ARPC1B, ARPC5, TUBB2A, CLDN1, WASL, ROCK1, TUBB6, HCLS1, FYN, NCK2, TUBB2B, TUBB4A, ACTG1",0.048176964684088,0.0282604091122217,FALSE
+"H358","Input","KEGG_PATHWAYS_IN_CANCER",0.29168,0.904,0.538,1132,0.758,"RAC2, LAMC2, PTGS2, SLC2A1, ITGA3, CDH1, LAMB3, AR, LAMA5, CTNNA1, MAX, PIK3R3, PIAS1, CTNNB1, CTNNA2, RXRA, PIK3CD, MAPK10, RB1, MAPK9, RUNX1, RALB, CCND1, MSH6, ETS1, ERBB2, RXRG, PTEN, SMAD3, MSH2, SKP2, RAC3, CTBP1, HIF1A, MECOM, MET, CKS1B, TGFB2, RXRB, KRAS, NRAS, IGF1R, ITGA6, CDK2, FZD6",0.269217724333611,0.120330794367946,FALSE
+"H358","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.50067,-1.54,0.0741,7692,0.242,"RPE, CRYL1, GUSB, XYLB, AKR1B1",1.13018179202067,0.616184634019569,FALSE
+"H358","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.34873,-1.05,0.358,6220,0.514,"PRPS1, PRPS1L1, TALDO1, PFKP, PFKM, PFKL, RPE, GPI, DERA, H6PD, PGLS",0.446116973356126,0.289036881004724,FALSE
+"H358","Input","KEGG_PEROXISOME",-0.44496,-1.37,0.12,7272,0.322,"HSD17B4, DHRS4, DAO, PXMP4, PRDX1, MLYCD, ECI2, IDH1, PEX5, PECR, DECR2, CAT, CRAT, ABCD1, HACL1, AGXT, IDH2, ACSL5, EHHADH, GSTK1, SOD1, FAR2, SOD2, NUDT19, PHYH, ECH1",0.920818753952375,0.492144128304169,FALSE
+"H358","Input","KEGG_PHENYLALANINE_METABOLISM",-0.35979,-1.11,0.296,8710,0.474,"GOT1, MAOB, DDC",0.528708288941061,0.324221658325915,FALSE
+"H358","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.27855,-0.857,0.597,6782,0.77,"PIP4K2A, PIP4K2B, PIK3C2A, PIK3R2, SYNJ1, PIK3C2B, OCRL, PIP5K1C, ITPR3, PLCG1, INPP5D, PIK3C3, INPP5K, PIKFYVE, PLCG2, PIK3R1, ITPKA, IMPA1, ITPK1, PIK3CB, ITPKB, ITPR1, ITPR2",0.224025668870631,0.113509274827518,FALSE
+"H358","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.42796,-1.3,0.159,7931,0.316,"CPOX, GUSB, EARS2, HMOX1, COX15, BLVRA, UROS, BLVRB, FTH1",0.798602875679548,0.500312917381596,FALSE
+"H358","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.4506,-1.41,0.103,7615,0.314,"FABP5, APOA1, OLR1, SCD, ILK, SLC27A6, ACSL5, EHHADH, HMGCS2, SLC27A1, APOA2, SORBS1, PCK2, GK, FABP1, CYP27A1, FABP7, FABP3",0.987162775294828,0.503070351926785,FALSE
+"H358","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.59486,-1.85,0.0129,6247,0.173,"ACOX2, AMACR, HSD17B4, AKR1D1, CYP27A1",1.88941028970075,0.761953896871205,TRUE
+"H358","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.41778,1.31,0.152,583,0.525,"LCK, UNG",0.818156412055227,0.279840696594043,FALSE
+"H358","Input","KEGG_PRION_DISEASES",-0.57953,-1.78,0.0405,8236,0.188,"FYN, BAX, C5, MAP2K2, SOD1, C9, IL6",1.39254497678533,0.72584215073632,TRUE
+"H358","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.45866,1.39,0.108,1098,0.715,"MAPK13, FZR1, CCNA2, PIK3R3, BUB1, PIK3CD, MAPK10, CCNB1, PLK1, MAPK9, CCNB2, MAD2L1, CDK1, RPS6KA1, KRAS, IGF1R, CDK2",0.96657624451305,0.145693958198919,FALSE
+"H358","Input","KEGG_PROPANOATE_METABOLISM",-0.57885,-1.78,0.0213,6689,0.188,"ECHS1, ALDH1B1, PCCA, ACADM, MLYCD, ALDH7A1, ACAT2, ACSS1, ACSS2, ACSS3, PCCB, EHHADH, MCEE, ALDH2, ABAT",1.67162039656126,0.72584215073632,TRUE
+"H358","Input","KEGG_PROSTATE_CANCER",0.26226,0.813,0.694,1404,0.787,"AR, PIK3R3, CTNNB1, PIK3CD, RB1, CCND1, ERBB2, PTEN, KRAS, NRAS, IGF1R, CDK2, PIK3CA, EP300, CREBBP",0.158640529545145,0.104025267640935,FALSE
+"H358","Input","KEGG_PROTEASOME",0.17383,0.532,0.987,1486,0.99,"PSME1, PSME2, PSMB8, PSME3",0.00568284733036327,0.00436480540245009,FALSE
+"H358","Input","KEGG_PROTEIN_EXPORT",-0.17313,-0.542,0.99,8519,0.988,"SEC11C, IMMP1L",0.00436480540245009,0.00524305541237188,FALSE
+"H358","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.54988,-1.69,0.0378,8513,0.189,"GLS, GLS2, ATP1B3, PCK2, AQP1, CA2",1.42250820016277,0.723538195826756,TRUE
+"H358","Input","KEGG_PURINE_METABOLISM",0.26219,0.818,0.695,982,0.79,"PDE5A, NT5E, POLA1, PRIM1, PRIM2, PKM, POLD3, NME7, POLD1, RRM2, NME3, POLA2, POLE3, POLR3C, PDE4D, POLR3F, ENTPD6, POLR3B, DCK, POLR3G",0.158015195409886,0.102372908709559,FALSE
+"H358","Input","KEGG_PYRIMIDINE_METABOLISM",0.39848,1.22,0.214,1339,0.489,"CDA, NT5E, POLA1, PRIM1, DUT, PRIM2, POLD3, NME7, POLD1, RRM2, UCK2, NME3, POLA2, POLE3, POLR3C, POLR3F, ENTPD6, POLR3B, DCK, POLR3G, TK1, TK2, PNP, UCK1, POLD2",0.669586226650809,0.31069114087638,FALSE
+"H358","Input","KEGG_PYRUVATE_METABOLISM",-0.45103,-1.37,0.129,7460,0.322,"ACYP1, PC, ALDH7A1, GRHPR, ACAT2, ACSS1, ACSS2, PCK2, AKR1B1, ALDH2, HAGH",0.889410289700751,0.492144128304169,FALSE
+"H358","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.21013,-0.641,0.936,7837,0.958,"ITGA1, GSN, PIKFYVE, PIK3R1, DOCK1, FGFR3, ENAH, CRKL, VCL, FGFR4, MYH10, ARHGEF6, FGD1, MAP2K2, FN1, FGFR1, ITGB8, PIK3CB, CRK, ITGB3, ACTG1, SOS1, IQGAP2, ITGA5, ITGA7, FGF13, FGF2, ITGA4",0.0287241512618947,0.0186344909214556,FALSE
+"H358","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.57295,-1.73,0.037,6267,0.201,"PRKAA1, PIK3R4, PRKAA2, ATG3, ATG4A, ULK1, PIK3C3, ATG12, ATG4B, GABARAPL1, ULK3",1.431798275933,0.696803942579511,TRUE
+"H358","Input","KEGG_RENAL_CELL_CARCINOMA",0.25478,0.8,0.68,1980,0.788,"SLC2A1, PIK3R3, PIK3CD, ETS1, HIF1A, MET, TGFB2, KRAS, NRAS, PIK3CA, EP300, CREBBP, ELOC, CDC42, RBX1, ELOB, JUN",0.167491087293764,0.103473782510445,FALSE
+"H358","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.53302,-1.68,0.0432,7507,0.179,"CTSA, ENPEP, ACE, AGT, ANPEP",1.36451625318509,0.747146969020107,TRUE
+"H358","Input","KEGG_RETINOL_METABOLISM",-0.38819,-1.19,0.227,8270,0.393,"CYP3A5, RDH10, ALDH1A2, ALDH1A1",0.643974142806877,0.405607449624573,FALSE
+"H358","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.43072,-1.34,0.148,7532,0.312,"ACP5, MTMR6, ACP2, ENPP1, PHPT1",0.829738284605043,0.505845405981557,FALSE
+"H358","Input","KEGG_RIBOSOME",0.27159,0.857,0.609,3836,0.751,"RPS4Y1, RPL22, FAU, RPS23, RPS25, RPS3A, RPL23A, RPL8, RPS11, RPS8, RPS29, RPL7, RPL34, RPS5, RPL28, RPL7A, RPS15, RPS13, RPL10, RPL18, RPS27L, RPL26, RPS17, RPS9, RPL37A, RPL36A, RPL36AL, RPS2, RPS6, RPL36, RPL15, RPL21, RPS18, RPL17, RPL10A, RPL5, RPL27, RPL19, RPL18A, RPL11, RPL14, RPL32, RPL13A, RPS16, MRPL13, RPL13",0.215382707367125,0.124360062995832,FALSE
+"H358","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.37634,1.17,0.258,952,0.499,"MAPK13, DDX3Y, ISG15, MAPK10, MAPK9, DDX58, TKFC",0.58838029403677,0.30189945437661,FALSE
+"H358","Input","KEGG_RNA_DEGRADATION",0.31524,0.977,0.432,2938,0.688,"XRN2, PAPOLA, EXOSC5, EXOSC6, DCPS, PAPOLG, EXOSC9, EXOSC8, EXOSC7, ENO1, DIS3, ENO3, EXOSC3, EXOSC10, EXOSC2, CNOT6, CNOT6L, MTREX, DDX6, DCP1A, LSM6, LSM8, LSM1, EXOSC1, LSM2",0.364516253185088,0.162411561764489,FALSE
+"H358","Input","KEGG_RNA_POLYMERASE",0.41045,1.26,0.184,3305,0.525,"POLR3C, POLR3F, POLR3B, POLR3G, POLR3A, POLR2K, POLR1B, POLR3H, POLR1A, POLR3D, POLR1E, POLR1C, POLR1D, POLR3K, POLR2B",0.735182176990464,0.279840696594043,FALSE
+"H358","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.23458,-0.728,0.822,6033,0.91,"SEPHS2, AHCY, MAT2B, METTL2B, TRMT11, GGT7, GGT1, LCMT1, PAPSS2",0.0851281824599496,0.0409586076789064,FALSE
+"H358","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.41269,1.28,0.183,1098,0.532,"LAMC2, PTGS2, ITGA3, LAMB3, LAMA5, MAX, PIK3R3, PIAS1, RXRA, PIK3CD, RB1, CCND1, RXRG, PTEN, SKP2, CKS1B, RXRB, ITGA6, CDK2",0.737548910269571,0.274088367704952,FALSE
+"H358","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.23245,-0.702,0.829,6730,0.921,"SNAP25, USE1, GOSR2, VAMP7, VAMP5, SNAP29, STX7, BET1, YKT6, STX2",0.0814454694497265,0.0357403698031511,FALSE
+"H358","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.24352,-0.742,0.792,6538,0.897,"SGPP1, GLB1, NEU1, ASAH1, ARSA, UGCG, GBA, KDSR, SMPD2, SMPD3, PLPP1, SMPD1",0.101274818410506,0.0472075569559079,FALSE
+"H358","Input","KEGG_SPLICEOSOME",0.40037,1.23,0.194,3679,0.504,"DHX8, DHX15, ALYREF, DDX42, SNRPB2, DHX16, CTNNBL1, DDX5, SNRPA1, HSPA2, PRPF3, AQR, CDC5L, SF3B1, NCBP1, DHX38, DDX46, U2AF2, SRSF5, CRNKL1, PUF60, SF3B3, RBMX, SRSF8, DDX39B, CWC15, SNRPE, BCAS2, PRPF4, PHF5A, SART1, HSPA1A, PLRG1, SNRPD1, SNRPD2, XAB2, SNRNP200, LSM6, EIF4A3, PRPF19, THOC1, SF3B4, RBM25, LSM8, USP39, SF3B6, SRSF9, LSM2, SF3A3, TRA2A, HNRNPM, HNRNPA1, SNW1, PRPF40A, SNRPB, ISY1, SF3B5, PRPF38A, SNRPA, U2AF1, PRPF8, LSM3, SF3A1, PPIL1, SNRPD3, SRSF6, HNRNPK, HSPA6, SRSF2, PRPF31, THOC2, PRPF6, SNRNP70",0.712198270069774,0.297569463554475,FALSE
+"H358","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.22692,-0.692,0.875,7549,0.925,"GYS1, GPI, GUSB, ENPP1, SI, UXS1",0.0579919469776868,0.0338582672609674,FALSE
+"H358","Input","KEGG_STEROID_BIOSYNTHESIS",-0.49274,-1.53,0.0696,7665,0.242,"CEL, LIPA, SOAT2, FDFT1, SQLE",1.15739076038944,0.616184634019569,FALSE
+"H358","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.72859,-2.27,0.00183,8270,0.0934,"CYP3A5, AKR1D1, CYP21A2, HSD3B1, AKR1C3, HSD17B2, AKR1C1, HSD11B2, AKR1C2",2.73754891026957,1.02965312376991,TRUE
+"H358","Input","KEGG_SULFUR_METABOLISM",-0.7871,-2.45,0,7602,0.0357,"SULT1A3, CHST13, SUOX, PAPSS2, CHST12, CHST11, SULT1A1",Inf,1.44733178388781,TRUE
+"H358","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.40922,-1.26,0.17,6645,0.341,"ELANE, CD40, TRIM21, C3, C5, C4A, C9",0.769551078621726,0.467245621007502,FALSE
+"H358","Input","KEGG_TASTE_TRANSDUCTION",0.47947,1.48,0.0845,1100,0.685,"SCNN1B, CACNA1A",1.07314329105031,0.164309428507574,FALSE
+"H358","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.50306,-1.58,0.0466,7194,0.224,"PDSS2, GGPS1, HMGCR, HMGCS1, ACAT2, HMGCS2, IDI1",1.33161408331,0.649751981665837,TRUE
+"H358","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.2907,0.908,0.529,1404,0.763,"SMURF1, THBS1, ID1, RPS6KB2, SMAD3, RBL1, ACVR1, TGFB2, PPP2CB, RPS6KB1, SMURF2, EP300, CREBBP",0.276544327964814,0.11747546204512,FALSE
+"H358","Input","KEGG_THYROID_CANCER",0.37034,1.14,0.242,1089,0.497,"CDH1, CTNNB1, RXRA, CCND1, RXRG, RXRB, KRAS, NRAS",0.616184634019569,0.303643611266668,FALSE
+"H358","Input","KEGG_TIGHT_JUNCTION",0.4082,1.26,0.182,1464,0.525,"CLDN7, PRKCH, CLDN4, F11R, CTNNA1, CLDN3, CTNNB1, CTNNA2, LLGL2, PATJ, CRB3, CASK, PTEN, MYH9, MYH11, RAB13, CSNK2A1, CSNK2A2, TJP1, MAGI3, CGN, KRAS, NRAS, EPB41L1, PPP2CB, TJP2, PRKCD, OCLN, PRKCZ, MYL12A, PRKCG, CSNK2B",0.739928612014925,0.279840696594043,FALSE
+"H358","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.26182,-0.829,0.664,6324,0.786,"MAPK8, RELA, IKBKG, AKT3, IRF3, TRAF3, CHUK, TBK1, CD40, PIK3R2, RIPK1, MAPK1, SPP1, IRAK4, CTSK, TRAF6, LBP, TAB1, PIK3R1, MAP3K7, MAPK12, MAPK11, TOLLIP, MAP2K2, PIK3CB, IFNAR2, IL6",0.177831920631982,0.104577453960592,FALSE
+"H358","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.55285,-1.71,0.0336,7375,0.183,"AOC1, KYNU, OGDH, ALDH7A1, CAT, OGDHL, ACAT2, EHHADH, MAOB, DDC, GCDH, ALDH2",1.47366072261016,0.737548910269571,TRUE
+"H358","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.48852,1.51,0.0756,1342,0.773,"IRS1, PIK3R3, PIK3CD, MAPK10, PKM, MAPK9, ABCC8, CACNA1A, PRKCD, PIK3CA, PRKCZ, PKLR",1.12147820449879,0.111820506081675,FALSE
+"H358","Input","KEGG_TYROSINE_METABOLISM",0.32926,1.01,0.418,410,0.637,"ALDH1A3, ADH4, ADH7, MAOA",0.378823718224965,0.19586056766465,FALSE
+"H358","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",0.27725,0.862,0.603,1362,0.765,"MAPK13, LCK, PIK3R3, PIK3CD, MAPK9, PPP3CA, PPP3R2, KRAS, NRAS, PPP3R1, TEC, PIK3CA, CHP1",0.219682687859849,0.116338564846382,FALSE
+"H358","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29576,0.908,0.531,2737,0.763,"FZR1, CDC20, UBE2C, SMURF1, PIAS1, UBE2E2, FANCL, UBE2S, UBE3A, WWP2, SKP2, CUL4A, UBE2W, BTRC, CUL3, UBR5, UBE2O, SMURF2, ITCH, UBA3, DDB2, ELOC, PIAS3, BRCA1, RBX1, ELOB, UBE4A, CUL4B, PPIL2, MAP3K1, RNF7, UBE2A, CUL5, MID1, UBA6, COP1, PML, DDB1, UBE2D2, UBE2K, UBE4B, PRPF19",0.274905478918531,0.11747546204512,FALSE
+"H358","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.61649,-1.9,0.0136,8770,0.171,"BCAT1",1.86646109162978,0.767003889607846,TRUE
+"H358","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.51404,-1.6,0.0475,7819,0.216,"ALDH7A1, ACADS, HMGCS1, BCKDHB, ACAT2, PCCB, EHHADH, MCEE, HMGCS2, BCAT1, ALDH2, ACADSB, ABAT, ACAA2",1.32330639037513,0.665546248849069,TRUE
+"H358","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.24199,0.738,0.785,1186,0.852,"PRKCH, PPP1R14A, PLA2G4A, PLCB1, MYL6, MYH11, MYLK, PLA2G12A, PRKCD",0.105130343254747,0.0695604052332999,FALSE
+"H358","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.29197,-0.899,0.551,5911,0.715,"DYNC1I2, DYNC2LI1, RAB5C, DYNC2H1, PRKACB, CREB5, RAB5B, CREB3L2, DYNC1LI1, DCTN4, DCTN6, DCTN5, DYNLL1, DCTN1, DCTN2",0.258848401148215,0.145693958198919,FALSE
+"H358","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.43288,1.34,0.143,1829,0.523,"MAPK13, RAC2, PTGS2, PIK3R3, PIK3CD, PLA2G4A, PPP3CA, RAC3, PPP3R2, PLA2G12A, KRAS, NRAS, PPP3R1, PIK3CA, CHP1, PRKCG, BAD, PPP3CB, CDC42",0.844663962534938,0.281498311132726,FALSE
+"H358","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.43673,-1.32,0.166,7218,0.321,"ATP6V1D, ATP6V0D2, ATP6V0A2, PDIA4, ATP6V1C2, PLCG1, ATP6V1A, ATP6V1H, ATP6V1B2, ATP6V1B1, ATP6V0A1, ATP6V1E1, PLCG2, KDELR1, ACTG1, ATP6V1G1",0.779891911959945,0.493494967595128,FALSE
+"H358","Input","KEGG_VIRAL_MYOCARDITIS",0.41889,1.34,0.125,984,0.523,"RAC2, ITGB2, CAV1, CCND1, MYH9, RAC3, MYH11, DAG1, CD55",0.903089986991944,0.281498311132726,FALSE
+"H358","Input","KEGG_WNT_SIGNALING_PATHWAY",0.43014,1.35,0.139,1464,0.591,"RAC2, NKD2, CTNNB1, CHD8, FOSL1, MAPK10, VANGL1, MAPK9, CCND1, PPP3CA, SMAD3, RAC3, CTBP1, DKK1, TBL1X, PLCB1, CSNK1E, DAAM1, TBL1XR1, PPP3R2, BTRC, CSNK2A1, CSNK2A2, CAMK2D, PPP2CB, PPP3R1, FZD6, CAMK2G, PPP2R5C, EP300, CHP1, PPP2R5E, CREBBP, PRKCG, CSNK2B",0.856985199745905,0.228412519118745,FALSE
+"A549","Input","KEGG_ABC_TRANSPORTERS",0.66076,1.96,0.00926,292,0.395,"ABCC2, ABCA1, ABCG2, ABCC8, ABCC3, ABCC1, ABCC4",2.03338901331807,0.40340290437354,FALSE
+"A549","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.38087,-1.09,0.329,6338,0.708,"FLT3, TCF7L1, RELA, IKBKB, MTOR, STAT5A, TCF7L2, SOS1, MAP2K1, PIK3CD, MAP2K2, BRAF, EIF4EBP1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PML, PIK3CB, NFKB1, AKT1, MAPK1, RUNX1, MAPK3",0.482804102050026,0.149966742310231,FALSE
+"A549","Input","KEGG_ADHERENS_JUNCTION",-0.25827,-0.742,0.79,8178,0.913,"AFDN, WAS, WASF2, CTNNA1, PTPN6, FARP2, CDH1, MAPK1, ERBB2, ACTG1, MAPK3, NECTIN1, BAIAP2, NECTIN4, RAC2",0.102372908709559,0.039529222465701,FALSE
+"A549","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.28132,-0.803,0.717,6358,0.848,"ACACB, RELA, ADIPOR1, IKBKB, MTOR, TRADD, MAPK9, PRKAA1, RXRA, RXRB, NFKBIE, MAPK10, CPT1A, NFKBIA, NFKB1, AKT1, ACSL1, ACSL5, STK11",0.1444808443322,0.0716041477432862,FALSE
+"A549","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.40005,-1.14,0.267,8462,0.671,"ASNS, GFPT1, ADSL, ASL, GPT2, IL4I1, ABAT, ASS1, GLUL, DDO",0.573488738635425,0.173277479831008,FALSE
+"A549","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.54035,-1.55,0.0669,7844,0.886,"PIK3R1, ATP1B1, KRAS, SCNN1G, PIK3CA, ATP1A1, ATP1A4, ATP1A3, PIK3CB, ATP1B3, MAPK1, MAPK3, PDPK1, HSD11B2, SCNN1A",1.17457388223218,0.0525662781129492,FALSE
+"A549","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.51331,-1.44,0.098,9161,0.67,"PLA2G12A, PLA2G2A",1.00877392430751,0.173925197299174,FALSE
+"A549","Input","KEGG_ALZHEIMERS_DISEASE",-0.21812,-0.598,0.954,8450,0.998,"PLCB1, FADD, COX7C, CACNA1F, CALM2, CASP3, MAPK1, MAPT, PLCB3, SNCA, CAPN1, MAPK3, MME, LPL",0.0204516252959049,0.000869458712628891,FALSE
+"A549","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.29233,-0.843,0.61,5457,0.806,"NARS2, FARSB, IARS2, SEPSECS, RARS2, SARS2, AARS2, DARS2, VARS2, WARS2, LARS2, FARSA, PARS2, TARS2, MARS2, CARS2",0.214670164989233,0.0936649581949093,FALSE
+"A549","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.50313,-1.38,0.127,7876,0.602,"GALK2, NANS, CYB5R1, GNPNAT1, GMPPB, GALE, PGM3, PGM1, GMPPA, GFPT1, HEXB, HK2, FPGT, RENBP, GCK, AMDHD2, UAP1, MPI, PGM2, HK1, GMDS",0.896196279044043,0.220403508742175,FALSE
+"A549","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.37017,1.09,0.308,1061,0.621,"NEFH, PRPH, PRPH2, GPX1, NEFL, BAD, MAP2K6, BCL2L1, PPP3R1",0.511449283499556,0.20690839982342,FALSE
+"A549","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.3026,-0.869,0.595,9089,0.781,"PSME2, PSME1, IFI30, CD74, B2M",0.22548303427145,0.1073489661227,FALSE
+"A549","Input","KEGG_APOPTOSIS",-0.21555,-0.608,0.952,7315,1,"PIK3CD, CASP10, RIPK1, MYD88, ENDOD1, PRKAR1B, CASP7, PIK3R1, PIK3CA, NFKBIA, IRAK4, FADD, PRKAR2B, PIK3CB, CASP3, NFKB1, AKT1, IL1RAP, CAPN1, BCL2, IL1A",0.0213630516155257,0,FALSE
+"A549","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.35969,-1.02,0.382,9161,0.716,"PLA2G12A, PTGS1, GPX6, GPX7, PLA2G2A, ALOX5",0.417936637088291,0.145086977692144,FALSE
+"A549","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.34839,-0.983,0.432,8468,0.716,"LAP3, ACY1, MAOB, ASL, PRODH, PRODH2, MAOA, CKB, ARG1, ASS1, CKMT2, GLUL, ARG2, CKMT1A",0.364516253185088,0.145086977692144,FALSE
+"A549","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.55562,1.67,0.0402,720,0.348,"DES, GJA1, ITGA3, CDH2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ACTN1, ACTN4, ATP2A2",1.39577394691553,0.458420756053419,FALSE
+"A549","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.57996,1.68,0.0334,1107,0.382,"ALDH2, ALDH1B1, UGDH, ALDH3A2",1.47625353318844,0.417936637088291,FALSE
+"A549","Input","KEGG_AXON_GUIDANCE",-0.36138,-1.04,0.364,7702,0.697,"RAC1, PAK2, ABLIM3, EPHB3, GSK3B, RASA1, DPYSL5, KRAS, NRAS, ROCK1, ARHGEF12, PAK3, NCK2, NTN1, CXCR4, PAK1, EPHA4, ROBO2, LIMK2, MAPK1, PLXNA3, SLIT1, SLIT3, EPHA1, MAPK3, PLXNA2, SLIT2, PAK5, PAK6, UNC5B, NFATC2, EFNB2, RAC2",0.438898616350944,0.156767221901991,FALSE
+"A549","Input","KEGG_BASAL_CELL_CARCINOMA",0.3861,1.13,0.266,907,0.663,"FZD2, FZD7, SUFU",0.575118363368933,0.178486471595227,FALSE
+"A549","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.32275,0.938,0.508,852,0.763,"GTF2E1, STON1, GTF2E2",0.294136287716081,0.11747546204512,FALSE
+"A549","Input","KEGG_BASE_EXCISION_REPAIR",0.38329,1.12,0.297,2845,0.64,"NEIL2, POLL, POLE3, POLE4, NTHL1, XRCC1, POLD4, POLD3, POLD1, POLB, MPG, POLD2, TDG, MBD4",0.527243550682788,0.193820026016113,FALSE
+"A549","Input","KEGG_BETA_ALANINE_METABOLISM",0.3743,1.09,0.332,1107,0.621,"ALDH2, ALDH1B1, ALDH3A2",0.478861916295964,0.20690839982342,FALSE
+"A549","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.59604,1.75,0.021,943,0.5,"SCD5, HACD1, ACOT2, ELOVL5, FADS1, FADS2, PECR",1.67778070526608,0.301029995663981,FALSE
+"A549","Input","KEGG_BLADDER_CANCER",-0.31342,-0.883,0.573,7636,0.802,"MAP2K2, BRAF, RASSF1, RAF1, THBS1, TYMP, KRAS, NRAS, E2F1, CDH1, MAPK1, RPS6KA5, CDKN2A, ERBB2, MAPK3",0.24184537803261,0.0958256317158365,FALSE
+"A549","Input","KEGG_BUTANOATE_METABOLISM",-0.37138,-1.07,0.343,8830,0.709,"ACAT2, AACS, ABAT, HMGCS2, OXCT1, BDH1",0.464705879957229,0.149353764816933,FALSE
+"A549","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52515,-1.5,0.0742,7558,0.959,"NFKBIE, MAP2K2, RAC1, VAV2, GSK3B, RAF1, PIK3R1, KRAS, NRAS, VAV1, BTK, PIK3CA, PLCG2, PTPN6, BCL10, NFKBIA, VAV3, CD79B, PIK3CB, NFKB1, AKT1, MAPK1, INPP5D, MAPK3, FOS, SYK, CARD11, NFATC2, DAPP1, RAC2",1.12959609472097,0.0181813928293364,FALSE
+"A549","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.38447,1.12,0.301,1261,0.64,"CD38, MYLK, BST1, PLCB4, PRKCG, ITPR1, ATP2B1, PRKCB, PLCD3, ATP2A2, TACR1, ADCY3, ADCY8, PPP3R1, SPHK2, GNAQ, PHKA1, PRKACA, PRKCA",0.521433504406157,0.193820026016113,FALSE
+"A549","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.42487,1.26,0.175,803,0.607,"TPM2, TPM1, CACNA2D2, CACNA2D1, ATP2A2, TPM4",0.756961951313706,0.216811308924742,FALSE
+"A549","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.40097,-1.15,0.273,9212,0.755,"ICOSLG, SDC3, NCAM1, NECTIN1, ITGAL, SDC2, ITGB8, CLDN11, CDH15, CDH3, CLDN3, CLDN7, CLDN4, CLDN18",0.563837352959244,0.122053048370812,FALSE
+"A549","Input","KEGG_CELL_CYCLE",0.20691,0.603,0.964,2255,0.977,"CDKN1A, TGFB2, MDM2, CCNB3, ANAPC11, ANAPC10, SMAD3, SMAD2, ATR, YWHAQ, PRKDC, STAG1, CCND1, ATM, CDC26, CDK6, CDC25B, TFDP2, ORC5, ANAPC4, BUB3, CDK4, MAD1L1, CDKN1B, CDC27",0.0159229660971692,0.0101054362812269,FALSE
+"A549","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.33049,-0.943,0.486,7315,0.758,"PIK3CD, GNAI2, PREX1, CCR4, PTK2B, RAP1B, CCL13, GRK6, BRAF, RAC1, VAV2, GSK3B, RAF1, GRK5, PIK3R1, CCL15, KRAS, NRAS, VAV1, PIK3CA, ROCK1, PLCB2, WAS, NFKBIA, VAV3, PRKCD, PLCB1, CXCR4, CRKL, PAK1, PIK3CB, GNG10, ARRB1, NFKB1, AKT1, MAPK1, GNG2, GRK2, PLCB3, GNG5, PRKCZ, MAPK3, STAT2, RAC2",0.313363730737707,0.120330794367946,FALSE
+"A549","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.27277,-0.796,0.689,7636,0.852,"MAP2K2, BRAF, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, HDAC1, CBLB, NFKBIA, E2F1, CRKL, PIK3CB, NFKB1, AKT1, MAPK1, BCR, CDKN2A, RUNX1, MAPK3, CBL, MECOM",0.161780778092374,0.0695604052332999,FALSE
+"A549","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.62733,-1.75,0.023,9641,0.615,"PER3",1.63827216398241,0.211124884224583,FALSE
+"A549","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.17608,-0.512,0.995,6120,1,"PCK2, CS, ACO1, MDH2, SUCLA2, OGDHL, IDH1, DLD, OGDH, ACO2, MDH1, DLAT, IDH2",0.00217691925427455,0,FALSE
+"A549","Input","KEGG_COLORECTAL_CANCER",-0.30952,-0.872,0.576,7566,0.785,"MAPK10, BRAF, RAC1, GSK3B, RAF1, CTNNB1, PIK3R1, KRAS, PIK3CA, PIK3CB, CASP3, AKT1, MAPK1, BIRC5, MAPK3, FOS, BCL2, RAC2",0.239577516576788,0.105130343254747,FALSE
+"A549","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.55397,1.64,0.0539,1069,0.346,"FGA, C1S, THBD, C9, SERPINE1, PLAUR, SERPIND1, TFPI, PLAU, MASP1, CD59, C1R, F3",1.26841123481326,0.460923901207223,FALSE
+"A549","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.32168,-0.936,0.488,8482,0.762,"CBS, ENOPH1, IL4I1, MTAP, CTH",0.311580177997289,0.1180450286604,FALSE
+"A549","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33143,0.985,0.419,1199,0.712,"TGFB2, CXCL5, EDAR, OSMR, TNFRSF10D, TGFBR2, TNFRSF12A, TGFBR1, TNFRSF10C, KITLG, CD70, TNFRSF10A, ACVR1, IL18, TNFRSF10B, ACVR1B, IL6ST, CD40",0.377785977033705,0.147520006363144,FALSE
+"A549","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.32311,-0.912,0.526,9447,0.772,"DDX58, RIPK3, CASP1",0.279014255846261,0.112382699664264,FALSE
+"A549","Input","KEGG_DILATED_CARDIOMYOPATHY",0.615,1.84,0.0136,911,0.456,"TPM2, DES, TPM1, ITGA3, TGFB2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ATP2A2, TPM4, ADCY3, ADCY8, ITGA1",1.86646109162978,0.341035157335565,FALSE
+"A549","Input","KEGG_DNA_REPLICATION",0.24818,0.715,0.822,2823,0.926,"POLE3, POLE4, RNASEH1, POLA2, POLD4, POLD3, SSBP1, POLD1, POLA1, PRIM2, POLD2, PRIM1, RNASEH2A",0.0851281824599496,0.0333890133180656,FALSE
+"A549","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.49682,-1.42,0.111,7112,0.676,"SOS1, MAP2K1, ETV6, KRAS, NOTCH2, MAPK1, MAPK3",0.954677021213343,0.170053304058364,FALSE
+"A549","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.50471,-1.45,0.0819,8431,0.862,"GSTA2, UGT2B17, MAOB, FMO2, FMO4, FMO5, ALDH1A3, MAOA, GSTM3, ADH4, ADH7, ADH1C, GSTM4",1.08671609823958,0.0644927341752872,FALSE
+"A549","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.36841,-1.05,0.367,5976,0.701,"UGT2B11, UGT2B4, UCK2, HPRT1, GUSB, NAT1, ITPA, UPP1, UCKL1, XDH, TYMP, CES1, CES2, TPMT, UGT2B17",0.435333935747911,0.154281982033341,FALSE
+"A549","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.46992,1.37,0.112,402,0.517,"COL5A2, COL4A1, COL5A1, COL4A2, ITGA3, ITGA5, ITGB1, ITGB5, LAMB1, CD44, ITGAV, FN1, ITGB3, SPP1",0.950781977329818,0.286509456906058,FALSE
+"A549","Input","KEGG_ENDOCYTOSIS",-0.23839,-0.678,0.899,8085,0.996,"PRKCI, PARD6A, ARFGAP2, DNM2, RAB22A, CBLB, RNF41, RAB11B, DNAJC6, CXCR4, VPS37B, CHMP4A, CHMP4B, SH3GLB1, ARRB1, VPS4B, ARAP1, ACAP2, GRK2, CHMP4C, ERBB4, PRKCZ, FGFR2, SH3GL2, LDLR, CBL, ARAP2, RAB11FIP4, ERBB3, PSD4, EPN3",0.0462403082667712,0.00174066157630127,FALSE
+"A549","Input","KEGG_ENDOMETRIAL_CANCER",-0.36937,-1.08,0.314,7636,0.702,"MAP2K2, BRAF, GSK3B, RAF1, CTNNB1, PIK3R1, CTNNA2, KRAS, NRAS, PIK3CA, CTNNA1, PIK3CB, CDH1, AKT1, MAPK1, ERBB2, MAPK3, PDPK1",0.503070351926785,0.153662887870195,FALSE
+"A549","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.48793,-1.39,0.124,7392,0.64,"TCIRG1, ATP6V0C, ATP6V0D1, MAPK10, RAC1, ATP6V0A1, MAPK14, PLCG2, ATP6AP1, ATP6V1C1, F11R, ATP6V1E1, NFKBIA, ATP6V1B2, ATP6V1F, PAK1, ATP6V1A, CASP3, NFKB1, ATP6V1H, ATP6V1D, ATP6V1B1, ATP6V1G1, MAPK12",0.906578314837765,0.193820026016113,FALSE
+"A549","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.28073,-0.783,0.71,7566,0.866,"MAPK10, AREG, MAP2K2, BRAF, EIF4EBP1, PAK2, GSK3B, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PAK3, PLCG2, NCK2, CBLB, CRKL, PAK1, PIK3CB, AKT1, MAPK1, ERBB2, ERBB4, MAP2K7, MAPK3, CBL, PAK5, PAK6, ERBB3",0.148741651280925,0.0624821079826534,FALSE
+"A549","Input","KEGG_ETHER_LIPID_METABOLISM",0.37443,1.07,0.352,1996,0.607,"PLPP1, PLA2G4A, PLPP3, CHPT1, PLD2, PLPP2, AGPS",0.453457336521869,0.216811308924742,FALSE
+"A549","Input","KEGG_FATTY_ACID_METABOLISM",-0.46214,-1.31,0.147,8234,0.647,"ALDH9A1, CPT1A, ACADM, ACAT2, ACSL1, GCDH, CPT2, ADH4, ADH7, ACSL5, ADH1C",0.832682665251824,0.1890957193313,FALSE
+"A549","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.49999,-1.41,0.111,7090,0.662,"MAPK9, SOS1, MAP2K1, PIK3CD, GAB2, MAP2K3, MAPK10, MAP2K2, RAC1, VAV2, RAF1, PIK3R1, KRAS, NRAS, VAV1, BTK, PIK3CA, MAPK14, PLCG2, VAV3, PRKCD, PIK3CB, AKT1, MAPK1, INPP5D, MAP2K7, PLA2G12A, MAPK3, PDPK1, SYK, PLA2G2A, MAPK12, RAC2",0.954677021213343,0.1791420105603,FALSE
+"A549","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.29827,-0.872,0.59,7702,0.785,"RAC1, VAV2, RAF1, PIK3R1, VAV1, PTPRC, PIK3CA, WAS, WASF2, DNM2, PLCG2, VAV3, PRKCD, SPHK1, CRKL, PAK1, PIK3CB, GSN, LIMK2, AKT1, MAPK1, INPP5D, AMPH, MARCKSL1, MAPK3, SYK, SCIN, RAC2",0.229147988357856,0.105130343254747,FALSE
+"A549","Input","KEGG_FOCAL_ADHESION",0.36156,1.08,0.321,991,0.622,"COL5A2, COL4A1, COL5A1, COL4A2, CAV2, MYLK, ITGA3, ITGA5, ITGB1, ITGB5, AKT3, FLNB, LAMB1, PRKCG, ITGAV, FN1, SRC, ITGB3, SPP1, ZYX, FLNA, ACTN1, ACTN4, CAV1, PPP1R12A, PRKCB, PARVA, LAMA5, ILK, BAD, ITGA1, IGF1R, PARVB",0.493494967595128,0.206209615309181,FALSE
+"A549","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.77497,-2.17,0,9658,0.286,"ALPI, ALPP, ALPG",Inf,0.543633966870957,FALSE
+"A549","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.46754,-1.34,0.143,8420,0.632,"GMPPA, ALDOB, FBP2, HK2, FPGT, FBP1, PFKFB2, PFKFB4, MPI, PFKL, HK1, GMDS, ALDOC",0.844663962534938,0.199282921717615,FALSE
+"A549","Input","KEGG_GALACTOSE_METABOLISM",-0.35035,-1,0.396,7649,0.736,"PFKM, GALK2, GALE, PGM1, HK2, GCK, PGM2, PFKL, HK1",0.402304814074488,0.133122185662501,FALSE
+"A549","Input","KEGG_GAP_JUNCTION",0.4356,1.29,0.15,1261,0.607,"GJA1, PLCB4, PRKCG, TUBB2B, LPAR1, SRC, TJP1, GNAI1, ITPR1, TUBA4A, PRKCB, ADCY3, ADCY8, GNAQ, PRKACA, PRKCA",0.823908740944319,0.216811308924742,FALSE
+"A549","Input","KEGG_GLIOMA",0.25313,0.747,0.805,1564,0.932,"CDKN1A, AKT3, PRKCG, MDM2, PRKCB, IGF1R, PRKCA, PIK3R2, CCND1",0.0942041196321315,0.0305840876460186,FALSE
+"A549","Input","KEGG_GLUTATHIONE_METABOLISM",-0.34838,-0.987,0.436,8014,0.741,"GGT7, GSTM1, OPLAH, GSTA2, RRM2, LAP3, GPX3, IDH2, GGCT, GSTM3, GPX6, GPX7, GSTM4",0.360513510731414,0.130181792020672,FALSE
+"A549","Input","KEGG_GLYCEROLIPID_METABOLISM",0.28138,0.821,0.673,491,0.847,"AKR1B1, ALDH2, ALDH1B1, PLPP1, PLPP3",0.171984935776023,0.0721165896692931,FALSE
+"A549","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.27319,-0.778,0.744,8081,0.866,"PEMT, ETNK1, PISD, MBOAT1, DGKH, DGKQ, PLA2G15, PLA2G12A, CHKB, LYPLA2, CDS1, PLA2G2A, PCYT2",0.128427064454121,0.0624821079826534,FALSE
+"A549","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.31233,0.923,0.496,564,0.778,"GLDC, PIPOX, GAMT",0.304518323509803,0.109020403010311,FALSE
+"A549","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.40878,-1.14,0.253,8234,0.671,"ALDH9A1, ACSS1, PGM1, DLAT, ALDOB, FBP2, HK2, FBP1, GCK, ALDH1A3, ADH4, ADH7, PGM2, PFKL, ACSS2, HK1, ADH1C, ALDOC",0.596879478824182,0.173277479831008,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.47409,-1.38,0.106,9330,0.602,"CSGALNACT1, UST",0.97469413473523,0.220403508742175,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.2526,0.746,0.786,2787,0.918,"NDST1, B3GALT6, EXTL2, B3GAT3",0.104577453960592,0.0371573187987575,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.39167,-1.12,0.285,8587,0.671,"B4GALT3, ST3GAL2, ST3GAL1",0.54515513999149,0.173277479831008,FALSE
+"A549","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.25406,-0.725,0.82,7713,0.933,"IDS, GNS, SGSH, HEXB, HPSE",0.0861861476162833,0.0301183562535,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",-0.50834,-1.44,0.118,8748,0.67,"HEXB, ST3GAL2, ST3GAL1",0.928117992693875,0.173925197299174,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.6881,-1.97,0.00705,8748,0.262,"HEXB, NAGA, ST3GAL2, ST3GAL1",2.1518108830086,0.581698708680255,FALSE
+"A549","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.49259,-1.44,0.0748,9433,0.67,"FUT3, ST3GAL4, B3GNT3",1.12609840213554,0.173925197299174,FALSE
+"A549","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.51744,1.51,0.0679,2983,0.455,"PIGB, PIGX, PIGG, PIGQ, PIGH, PIGO, PIGW, PIGN",1.1681302257195,0.341988603342888,FALSE
+"A549","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",-0.51685,-1.49,0.0665,7465,0.895,"PGP, GLYCTK, MTHFD2L, ACO2, MDH1, HYI, AFMID",1.1771783546969,0.048176964684088,FALSE
+"A549","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31728,-0.899,0.581,7470,0.779,"PTK2B, MAP2K3, MAPK10, MAP3K4, MAP2K2, RAF1, KRAS, NRAS, CALML3, PLCB2, MAPK14, PRKCD, PLCB1, MAP3K3, CACNA1F, CALM2, MAPK1, PLCB3, MAP2K7, PLA2G12A, MAPK3, PLA2G2A, MMP14, MAPK12",0.235823867609669,0.108462542327436,FALSE
+"A549","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.20165,-0.586,0.976,7757,0.996,"GSK3B, WNT5B, CSNK1A1",0.0105501823333082,0.00174066157630127,FALSE
+"A549","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.50287,1.47,0.0819,911,0.445,"CD38, ITGA3, ITGA5, CD44, ITGB3, KITLG, CD59, ITGA1",1.08671609823958,0.351639989019068,FALSE
+"A549","Input","KEGG_HISTIDINE_METABOLISM",0.3877,1.16,0.241,316,0.646,"ALDH3A1, ALDH3B1, ALDH2, ALDH1B1",0.617982957425132,0.189767482004916,FALSE
+"A549","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.47319,1.4,0.105,2666,0.497,"RAD54L, BRCA2, EME1, MUS81, NBN, BLM, RAD54B, POLD4, POLD3, SSBP1, POLD1, TOP3A, RAD51C, POLD2",0.978810700930062,0.303643611266668,FALSE
+"A549","Input","KEGG_HUNTINGTONS_DISEASE",0.21392,0.632,0.955,3502,0.97,"TGM2, PLCB4, GPX1, ITPR1, POLR2D, AP2A2, GNAQ, HIP1, NDUFA2, BBC3, CLTA, SDHC, POLR2L, AP2M1, SDHA, POLR2I, AP2S1, SDHB, ATP5PF, SDHD, NDUFS6, POLR2E, SLC25A6, NDUFV3, POLR2G, UQCRFS1, CLTC, NDUFB2, NDUFA10, NDUFV1, NDUFA7, NDUFA5, SLC25A4, NDUFS1, AP2A1, BAX, COX6B1, DNAL1, DCTN1, NDUFB9, NDUFS5, NDUFB7, COX7A2L, VDAC1, AP2B1, NDUFS4, DCTN2, NDUFB3, HAP1",0.0199966284162537,0.0132282657337552,FALSE
+"A549","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.58381,1.71,0.0423,911,0.471,"TPM2, DES, TPM1, ITGA3, TGFB2, CACNA2D2, CACNA2D1, SGCD, ITGA5, ITGB1, ITGB5, ITGAV, ITGB3, ATP2A2, TPM4, ITGA1",1.37365963262496,0.326979092871104,FALSE
+"A549","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.3942,-1.14,0.251,7200,0.671,"PIP5K1A, PIK3CD, TPI1, INPPL1, ISYNA1, ALDH6A1, PIK3C3, PIK3CA, PLCB2, PLCG2, ITPKA, PLCB1, ITPK1, PIK3CB, PIK3C2B, PI4KB, SYNJ1, INPP5B, IMPA2, PLCB3",0.600326278518962,0.173277479831008,FALSE
+"A549","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.32829,-0.955,0.455,7090,0.754,"MAPK9, SOS1, MAP2K1, PRKAA1, PTPN1, PIK3CD, SORBS1, MKNK1, RAPGEF1, MAPK10, PHKG2, MAP2K2, BRAF, EIF4EBP1, PRKAR1B, GSK3B, RAF1, PIK3R1, KRAS, NRAS, PRKCI, PIK3CA, CALML3, CBLB, GYS1, PRKAR2B, CRKL, PIK3CB, CALM2, AKT1, MAPK1, FBP2, HK2, FOXO1, FBP1, GCK, INPP5D, PRKCZ, PPP1R3D, MAPK3, PDPK1, CBL, HK1",0.341988603342888,0.122628654130226,FALSE
+"A549","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.39955,-1.14,0.279,6996,0.671,"IL15RA, IL6, CXCR4, TNFSF13B, ICOSLG",0.554395796726402,0.173277479831008,FALSE
+"A549","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.34543,-0.983,0.425,7571,0.716,"IL6, SPRED2, PIK3R1, LIFR, PIK3CA, CBLB, PTPN6, IFNAR1, STAT6, PIK3CB, SPRY4, AKT1, IRF9, STAT2, EPO, CBL, PRLR, SPRY1",0.371611069949688,0.145086977692144,FALSE
+"A549","Input","KEGG_LEISHMANIA_INFECTION",-0.40968,-1.16,0.25,8229,0.794,"MAPK14, PTPN6, NFKBIA, IRAK4, NFKB1, MAPK1, MARCKSL1, MAPK3, FOS, IL1A, MAPK12",0.602059991327962,0.100179497572904,FALSE
+"A549","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.47542,-1.39,0.115,7702,0.64,"RAC1, VAV2, ITGB2, CTNNB1, PIK3R1, CTNNA2, VAV1, OCLN, PIK3CA, ROCK1, AFDN, MAPK14, PLCG2, F11R, CTNNA1, RASSF5, VAV3, CXCR4, PIK3CB, ICAM1, ACTG1, ITGAL, CLDN11, CLDN3, MAPK12, CLDN7, RAC2, CLDN4, CLDN18",0.939302159646388,0.193820026016113,FALSE
+"A549","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.52094,1.52,0.0716,1107,0.485,"ALDH2, ALDH1B1, ALDH3A2",1.14508697769214,0.314258261397736,FALSE
+"A549","Input","KEGG_LONG_TERM_DEPRESSION",0.27085,0.789,0.738,1261,0.882,"PLCB4, PRKCG, PLA2G4A, GNAI1, ITPR1, PRKCB, GNA13, IGF1R, GNAQ, PRKCA",0.131943638176958,0.0545314148681803,FALSE
+"A549","Input","KEGG_LONG_TERM_POTENTIATION",0.28298,0.844,0.637,1261,0.846,"PLCB4, PRKCG, ITPR1, PPP1R12A, PRKCB, ADCY8, PPP3R1, GNAQ, PRKACA, PRKCA",0.19586056766465,0.0726296369609765,FALSE
+"A549","Input","KEGG_LYSINE_DEGRADATION",0.36706,1.1,0.312,316,0.64,"PLOD2, PIPOX, ALDH2, ALDH1B1",0.505845405981557,0.193820026016113,FALSE
+"A549","Input","KEGG_LYSOSOME",-0.40736,-1.15,0.249,7182,0.755,"MAN2B1, AP3M2, NEU1, PPT2, SUMF1, TCIRG1, ATP6V0C, ATP6V0D1, SMPD1, IGF2R, IDS, GNS, ATP6V0A1, AP1S1, SGSH, SCARB2, GGA2, NPC2, ATP6AP1, CTSH, SLC11A2, CTSK, CTSO, LIPA, PPT1, HEXB, SLC17A5, DNASE2, SORT1, GGA1, ATP6V1H, FUCA1, AP1B1, PLA2G15, CLN5, NAGA, GM2A, LAMP1, CTSC, AP1M2, CTSE, MANBA, LAMP3, LAPTM5",0.603800652904264,0.122053048370812,FALSE
+"A549","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.23817,-0.672,0.889,8501,0.993,"MAPKAPK2, MAP3K5, CRKL, MAP3K3, PAK1, CACNA1F, DUSP10, CASP3, ARRB1, RPS6KA4, NFKB1, AKT1, MAPK1, RPS6KA5, MAPT, LAMTOR3, STMN1, MAPKAPK3, MAP4K2, MAP2K7, FGFR2, PLA2G12A, MAPK3, FOS, RPS6KA1, NFATC2, PLA2G2A, IL1A, MECOM, MAPK12, RAC2",0.0510982390297863,0.00305075150461883,FALSE
+"A549","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.3633,-1.03,0.37,8892,0.706,"HES1, GCK, IAPP",0.431798275933005,0.151195298948196,FALSE
+"A549","Input","KEGG_MELANOGENESIS",0.33522,0.988,0.393,1261,0.724,"FZD2, PLCB4, PRKCG, GNAI1, PRKCB, FZD7, KITLG, ADCY3, ADCY8, MITF, GNAQ, PRKACA, PRKCA",0.405607449624573,0.140261433802853,FALSE
+"A549","Input","KEGG_MELANOMA",0.43539,1.27,0.188,977,0.617,"FGF13, FGF2, CDKN1A, AKT3, MDM2, BAD, MITF, IGF1R",0.72584215073632,0.209714835966758,FALSE
+"A549","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.41251,1.21,0.202,318,0.622,"AKR1C2, ALDH3A1, AKR1C1, ALDH3B1, AKR1C3, CYP2S1",0.694648630553376,0.206209615309181,FALSE
+"A549","Input","KEGG_MISMATCH_REPAIR",-0.21391,-0.615,0.959,2094,1,"PMS2, POLD4, POLD3, SSBP1, MSH6, POLD1, POLD2, MSH3, MSH2, MLH1, RPA1, PCNA, RPA2, RFC1, RPA3, RFC2, RFC5, RFC4, RFC3, LIG1, EXO1",0.0181813928293364,0,FALSE
+"A549","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.38951,-1.11,0.29,7644,0.678,"BRAF, EIF4EBP1, PIK3R1, PIK3CA, CAB39L, PIK3CB, AKT1, MAPK1, CAB39, MAPK3, PDPK1, RPS6KA1, STK11",0.537602002101044,0.168770306132937,FALSE
+"A549","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.43024,-1.24,0.189,7636,0.665,"MAP2K2, BRAF, RAC1, VAV2, RAF1, ITGB2, PIK3R1, MICA, KRAS, NRAS, VAV1, PIK3CA, PLCG2, PTPN6, IFNAR1, VAV3, RAET1L, ULBP2, PAK1, PIK3CB, ICAM1, CASP3, MAPK1, SH3BP2, MAPK3, LCK, ITGAL, SYK, NFATC2, RAC2",0.723538195826756,0.177178354696895,FALSE
+"A549","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.29375,-0.825,0.648,9000,0.814,"PRSS2, HCRTR1, TSPO, PRLR",0.188424994129407,0.0893755951107988,FALSE
+"A549","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.44965,-1.29,0.178,7498,0.668,"RAP1B, RAPGEF1, NFKBIE, MAPK10, MAP2K2, BRAF, RAC1, GSK3B, RAF1, ARHGDIA, PIK3R1, KRAS, NRAS, FRS2, PIK3CA, CALML3, MAPK14, PLCG2, NFKBIA, PRKCD, IRAK4, MAPKAPK2, MAP3K5, CRKL, MAP3K3, NGFR, PIK3CB, CALM2, RPS6KA4, NFKB1, AKT1, MAPK1, RPS6KA5, SORT1, MAP2K7, MAPK3, PDPK1, ARHGDIB, RPS6KA1, BCL2, MAPK12",0.749579997691106,0.175223537524454,FALSE
+"A549","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.45827,1.35,0.136,163,0.521,"NNMT, CD38, BST1",0.866461091629782,0.283162276700476,FALSE
+"A549","Input","KEGG_NITROGEN_METABOLISM",0.40232,1.18,0.229,667,0.631,"CPS1, GLUD2, CA12, CA8, GLS, GLS2",0.640164517660112,0.199970640755866,FALSE
+"A549","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.59547,-1.71,0.0215,8767,0.529,"NFKB1, MAPK1, MAPK3, CASP1, MAPK12, CASP5",1.66756154008439,0.276544327964814,FALSE
+"A549","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.40184,1.19,0.227,2300,0.637,"PRKDC, POLL, DCLRE1C, LIG4",0.643974142806877,0.19586056766465,FALSE
+"A549","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.32196,-0.916,0.512,7112,0.773,"SOS1, MAP2K1, PIK3CD, RXRA, RXRB, MAP2K2, BRAF, RASSF1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PLCG2, RASSF5, E2F1, PIK3CB, AKT1, MAPK1, CDKN2A, ERBB2, MAPK3, PDPK1",0.290730039024169,0.111820506081675,FALSE
+"A549","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.35897,1.05,0.368,734,0.633,"JAG1, NUMBL, JAG2, NCOR2, DTX2",0.434152181326482,0.198596289982645,FALSE
+"A549","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.32436,0.948,0.475,3620,0.759,"DDB2, ERCC8, XPC, CETN2, POLE3, ERCC1, POLE4, POLD4, GTF2H1, POLD3, GTF2H5, POLD1, CCNH, POLD2, GTF2H2, ERCC2, MNAT1, CDK7, GTF2H3, CUL4B, GTF2H4, XPA, RPA1, POLE2, ERCC3",0.323306390375133,0.11975822410452,FALSE
+"A549","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.22791,-0.66,0.916,7192,0.999,"MGAT1, ALG9, STT3A, ALG6, ALG11, MGAT3, MGAT5, B4GALT3, MGAT4B, MAN1A1, ST6GAL1",0.0381045263321496,0.000434511774017692,FALSE
+"A549","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.40274,-1.14,0.28,8145,0.671,"CALML3, CALM2, PRKG2, CLCA2",0.552841968657781,0.173277479831008,FALSE
+"A549","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.36659,-1.05,0.363,6727,0.701,"GART, MTR, SHMT1, DHFR, MTHFD2L, MTHFR, AMT, TYMS, ALDH1L1",0.440093374963888,0.154281982033341,FALSE
+"A549","Input","KEGG_OOCYTE_MEIOSIS",-0.26978,-0.777,0.74,7793,0.859,"PPP2R5B, CDK2, AURKA, CCNB1, MOS, CALML3, SMC1A, SMC3, CALM2, PPP2R1B, PLK1, CDK1, MAPK1, PPP2R5A, PTTG1, MAPK3, RPS6KA1, MAPK12",0.130768280269024,0.0660068361687577,FALSE
+"A549","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.43545,-1.24,0.2,6677,0.665,"AGA, GBA, MAN2B1, NEU1, MAN2B2, FUCA2, HEXB, FUCA1, MANBA",0.698970004336019,0.177178354696895,FALSE
+"A549","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.21682,-0.619,0.937,6657,1,"COX6C, NDUFB5, NDUFB1, ATP5F1C, CYC1, ATP5PB, COX7A2, ATP5MG, TCIRG1, ATP6V0C, ATP6V0D1, PPA2, ATP6V0A1, PPA1, ATP6AP1, ATP6V1C1, ATP6V1E1, ATP6V1B2, ATP6V1F, COX7C, ATP6V1A, ATP12A, ATP6V1H, ATP6V1D, ATP6V1B1, ATP6V1G1",0.0282604091122217,0,FALSE
+"A549","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.36079,-1.04,0.362,8426,0.697,"GALNT5, GALNT12, ST6GALNAC1, ST3GAL2, GCNT1, ST3GAL1, GALNT6, GALNT3",0.441291429466834,0.156767221901991,FALSE
+"A549","Input","KEGG_P53_SIGNALING_PATHWAY",0.28525,0.829,0.676,542,0.846,"TP53I3, CDKN1A, SERPINE1, MDM2, ZMAT3, CCNB3, DDB2",0.170053304058364,0.0726296369609765,FALSE
+"A549","Input","KEGG_PANCREATIC_CANCER",-0.31114,-0.88,0.578,7566,0.798,"MAPK10, BRAF, RAC1, RAF1, PIK3R1, RALBP1, KRAS, PIK3CA, RALA, E2F1, PIK3CB, ARHGEF6, NFKB1, AKT1, MAPK1, CDKN2A, ERBB2, RAD51, MAPK3, RAC2",0.238072161579471,0.0979971086492706,FALSE
+"A549","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.3068,-0.876,0.584,7354,0.796,"COASY, PANK3, PANK4, PPCS",0.233587152887601,0.0990869322623309,FALSE
+"A549","Input","KEGG_PARKINSONS_DISEASE",-0.13765,-0.394,1,8618,1,"COX7C, CASP3, SNCA, UBE2L6, UBA7",0,0,FALSE
+"A549","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.22644,0.674,0.91,1500,0.97,"ITGB1, TUBB2B, TUBA4A, YWHAQ, PRKCA, CD14, TUBB6, ACTB",0.0409586076789064,0.0132282657337552,FALSE
+"A549","Input","KEGG_PATHWAYS_IN_CANCER",0.29415,0.853,0.615,1020,0.862,"FGF13, FGF2, COL4A1, FZD2, CDKN1A, COL4A2, ITGA3, TGFB2, ITGB1, AKT3, LAMB1, PRKCG, ITGAV, FN1, MDM2, DAPK3, TGFBR2, AR, DAPK1, PRKCB, TGFBR1, FZD7, KITLG, LAMA5, EGLN1, BAD, SUFU, MITF, IGF1R, SMAD3, BCL2L1",0.211124884224583,0.0644927341752872,FALSE
+"A549","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.39768,1.15,0.246,747,0.643,"AKR1B1, UGDH",0.609064892896621,0.191789027075778,FALSE
+"A549","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.44452,-1.28,0.173,8377,0.667,"PGM1, ALDOB, PGLS, FBP2, FBP1, PGM2, PFKL, ALDOC",0.761953896871205,0.175874166083451,FALSE
+"A549","Input","KEGG_PEROXISOME",-0.22017,-0.619,0.942,8477,1,"FAR2, FAR1, PXMP4, PMVK, ACSL1, ABCD1, IDH2, ACSL5, NUDT12, DDO",0.0259490972071227,0,FALSE
+"A549","Input","KEGG_PHENYLALANINE_METABOLISM",0.41027,1.23,0.196,222,0.636,"ALDH3A1, ALDH3B1",0.707743928643524,0.196542884351586,FALSE
+"A549","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.34104,-0.987,0.446,8099,0.741,"PIK3C3, PIK3CA, CALML3, PLCB2, PLCG2, ITPKA, PLCB1, ITPK1, PIK3CB, DGKH, CALM2, PIK3C2B, PI4KB, SYNJ1, INPP5B, IMPA2, DGKQ, PLCB3, INPP5D, CDS1",0.350665141287858,0.130181792020672,FALSE
+"A549","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.28214,0.838,0.648,1831,0.843,"HMOX1, COX15, CPOX, FECH, HCCS",0.188424994129407,0.0741724253752577,FALSE
+"A549","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.47291,-1.35,0.145,8533,0.637,"ACADM, FABP1, FABP2, ACSL1, SCD, CYP27A1, CPT2, DBI, GK, PDPK1, HMGCS2, FABP6, ACSL5, PLTP, LPL",0.838631997765025,0.19586056766465,FALSE
+"A549","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.316,-0.902,0.553,7958,0.782,"TAP2, BTK, PTPRC, LCK",0.257274868695302,0.106793246940152,FALSE
+"A549","Input","KEGG_PRION_DISEASES",-0.32726,-0.945,0.499,8788,0.764,"MAPK1, MAPK3, NCAM1, IL1A",0.30189945437661,0.11690664142431,FALSE
+"A549","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.29023,-0.832,0.661,7090,0.81,"MAPK9, MAP2K1, HSP90AB1, PIK3CD, GNAI2, PKMYT1, CCNA2, MAPK10, BRAF, RAF1, CDK2, PIK3R1, CCNB1, KRAS, PIK3CA, MOS, MAPK14, PIK3CB, FZR1, PLK1, CDK1, AKT1, MAPK1, MAPK3, RPS6KA1, MAPK12",0.17979854051436,0.0915149811213502,FALSE
+"A549","Input","KEGG_PROPANOATE_METABOLISM",-0.32193,-0.928,0.521,7870,0.769,"PCCA, ACSS3, ALDH6A1, ALDH9A1, ACSS1, ACADM, ACAT2, ABAT, ACSS2",0.283162276700476,0.114073660198569,FALSE
+"A549","Input","KEGG_PROSTATE_CANCER",-0.32041,-0.92,0.538,7112,0.775,"SOS1, MAP2K1, HSP90AB1, CREB5, PIK3CD, GSTP1, MAP2K2, BRAF, GSK3B, RAF1, CDK2, CTNNB1, PIK3R1, CREB3L2, KRAS, NRAS, PIK3CA, PDGFC, NFKBIA, E2F1, PIK3CB, NFKB1, AKT1, MAPK1, ERBB2, FOXO1, FGFR2, MAPK3, PDPK1, BCL2",0.269217724333611,0.11069829749369,FALSE
+"A549","Input","KEGG_PROTEASOME",-0.36966,-1.06,0.343,9089,0.704,"PSME2, PSME1, PSMB8, PSMB10",0.464705879957229,0.152427340857888,FALSE
+"A549","Input","KEGG_PROTEIN_EXPORT",0.18109,0.552,0.988,479,0.986,"SEC61A2",0.00524305541237188,0.0061230850587888,FALSE
+"A549","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.4405,-1.25,0.176,7927,0.689,"ATP1B1, MDH1, ATP1A1, ATP1A4, ATP1A3, ATP1B3, SLC38A3, CA2",0.75448733218585,0.161780778092374,FALSE
+"A549","Input","KEGG_PURINE_METABOLISM",0.24822,0.747,0.81,2719,0.932,"NME4, PDE4D, PAPSS2, ADA, POLR2D, PFAS, ADCY3, ADCY8, NPR2, POLR1E, PDE6C, NT5C, PDE8A, POLE3, POLE4, PKM, ENPP1, POLR2L, PRPS1, PRPS1L1, POLR3H, RRM2B, POLR2I, PDE1C, PDE8B, POLR3D, POLA2, POLD4, POLD3, AK4, PKLR, POLD1, POLR2E, NME2, NME1, POLA1, POLR2G, PRIM2, PNPT1, POLD2, PRIM1",0.0915149811213502,0.0305840876460186,FALSE
+"A549","Input","KEGG_PYRIMIDINE_METABOLISM",0.23836,0.727,0.845,2719,0.937,"NME4, CTPS1, POLR2D, CDA, POLR1E, NT5C, TXNRD1, POLE3, POLE4, POLR2L, POLR3H, RRM2B, POLR2I, POLR3D, POLA2, POLD4, POLD3, CAD, POLD1, POLR2E, NME2, NME1, POLA1, POLR2G, PRIM2, PNPT1, POLD2, PRIM1",0.0731432910503077,0.0282604091122217,FALSE
+"A549","Input","KEGG_PYRUVATE_METABOLISM",0.28395,0.846,0.652,2381,0.859,"AKR1B1, ALDH2, ALDH1B1, ME3, ALDH3A2, PKM, HAGH, GRHPR, ME2, ALDH7A1, LDHA, PC, PKLR",0.18575240426808,0.0660068361687577,FALSE
+"A549","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.24462,0.715,0.839,911,0.926,"FGF13, FGF2, MYLK, ITGA3, ITGA5, ITGB1, ITGB5, ITGAV, FN1, ITGB3, RDX, ACTN1, ACTN4, CFL2, PPP1R12A, MSN, RRAS, ARHGEF4, GNA13, ITGA1",0.0762380391712997,0.0333890133180656,FALSE
+"A549","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.40139,-1.15,0.262,6945,0.755,"ATG7, PIK3R4, BECN1, PRKAA1, ATG4A, PIK3C3, GABARAPL1, GABARAPL2",0.581698708680255,0.122053048370812,FALSE
+"A549","Input","KEGG_RENAL_CELL_CARCINOMA",-0.34015,-0.975,0.434,7111,0.722,"HGF, SOS1, MAP2K1, PIK3CD, RAP1B, RAPGEF1, MAP2K2, BRAF, RAC1, PAK2, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, PAK3, CRKL, PAK1, PIK3CB, FLCN, AKT1, MAPK1, MAPK3, PAK5, PAK6",0.362510270487489,0.141462802430361,FALSE
+"A549","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.32666,0.978,0.449,717,0.711,"ENPEP, NLN",0.347753658996677,0.148130399270234,FALSE
+"A549","Input","KEGG_RETINOL_METABOLISM",0.37317,1.1,0.297,1303,0.64,"ALDH1A1, ALDH1A2, DHRS3, RETSAT, RDH10",0.527243550682788,0.193820026016113,FALSE
+"A549","Input","KEGG_RIBOFLAVIN_METABOLISM",0.4058,1.21,0.205,1653,0.622,"RFK, ENPP1",0.688246138944246,0.206209615309181,FALSE
+"A549","Input","KEGG_RIBOSOME",0.57171,1.7,0.036,3500,0.409,"RPS4Y1, RPL22L1, RPL35, RPL36, RPS6, RPL32, RPL18, RPLP2, RPL24, RSL24D1, RPS24, RPL28, RPS8, RPS12, RPL7A, RPL26, RPL18A, RPL13A, RPSA, RPL17, RPL36A, RPL36AL, RPL35A, RPL6, RPL23A, RPL9, RPL27A, RPL31, RPL21, RPL23, RPL22, RPS3A, RPS26, RPL12, RPL34, RPL37A, RPS28, RPL10A, RPL4, RPL3, RPS2, RPL7, FAU, RPL29, RPS18, RPL27, RPS4X, RPS29, RPL5, RPL11, RPS15A, RPL14, RPL30, MRPL13, RPL13, RPL8, RPS9, RPS15, RPS3, RPS17, RPLP0, RPS23",1.44369749923271,0.388276691992658,FALSE
+"A549","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.34822,-1.01,0.408,8229,0.727,"MAPK14, NFKBIA, FADD, SIKE1, NFKB1, IFIH1, DDX58, DHX58, ISG15, MAPK12",0.38933983691012,0.138465589140962,FALSE
+"A549","Input","KEGG_RNA_DEGRADATION",0.36616,1.07,0.337,2448,0.607,"TENT4A, PARN, ZCCHC7, MPHOSPH6, TTC37, EXOSC1, C1D, ENO3, SKIV2L, XRN2, EXOSC8, PAPOLG, EXOSC5, EXOSC10, MTREX, EXOSC9, EXOSC4, EXOSC3, DCP1B, EXOSC7, EXOSC6",0.472370099128661,0.216811308924742,FALSE
+"A549","Input","KEGG_RNA_POLYMERASE",0.51095,1.47,0.103,4124,0.445,"POLR2D, POLR1E, POLR2L, POLR3H, POLR2I, POLR3D, POLR2E, POLR2G, POLR3A, POLR3C, POLR3G, POLR1A, POLR3GL, POLR3F, POLR3K, POLR3B",0.987162775294828,0.351639989019068,FALSE
+"A549","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.27573,0.814,0.702,1692,0.846,"GGT1, PAPSS2, MAT2A, MAT1A, GGT5",0.153662887870195,0.0726296369609765,FALSE
+"A549","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.35319,1.04,0.393,376,0.636,"COL4A1, COL4A2, ITGA3, ITGB1, AKT3, LAMB1, ITGAV, FN1",0.405607449624573,0.196542884351586,FALSE
+"A549","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.29286,-0.836,0.666,7613,0.811,"STX6, STX18, SNAP23, STX16, SEC22B, SNAP47, STX12, STX7, SNAP29, VAMP4, YKT6, VAMP8, STX3, VAMP5",0.176525770829699,0.090979145788844,FALSE
+"A549","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.29964,-0.858,0.605,9645,0.785,"SMPD3, UGT8",0.218244625347531,0.105130343254747,FALSE
+"A549","Input","KEGG_SPLICEOSOME",0.21371,0.639,0.932,6295,0.993,"HSPA2, HSPA1L, DDX42, TRA2A, SNRPD3, SNRPB, U2AF1, DDX46, SRSF9, DDX23, SNRPG, PUF60, SF3B5, U2AF2, SNU13, THOC1, DDX5, SNRPF, HNRNPA1, RBMX, SRSF7, THOC3, SNRNP70, SF3A1, HNRNPC, SNRPC, SF3B6, SF3A2, SRSF2, SNRPA, SMNDC1, SNRPD1, SNRPD2, SF3A3, THOC2, CHERP, SF3B1, PRPF8, SRSF3, SRSF8, EFTUD2, DDX39B, HSPA6, HNRNPA3, SRSF1, TCERG1, LSM2, PHF5A, TRA2B, NCBP2, PPIL1, SNRPE, NCBP1, SNW1, SRSF4, PRPF3, HSPA8, ALYREF, SNRNP40, SRSF10, USP39, HNRNPK, RBM22, RBM17, PRPF40A, SF3B4, CDC5L, SNRNP200, RBM25, PLRG1, PRPF19, HSPA1A, DHX38, PQBP1, SF3B2, PRPF31, CRNKL1, CTNNBL1, HNRNPM, TXNL4A, PRPF4, RBM8A, ZMAT2, U2SURP, SNRPA1, ACIN1, SF3B3, BCAS2, LSM4, XAB2, DHX8, AQR, SNRPB2, CCDC12, WBP11, PRPF40B, SRSF5, EIF4A3, LSM3, SART1, SLU7, LSM7, ISY1, LSM8, PCBP1, PRPF38B, DHX15, SRSF6, DHX16, PRPF6, SYF2, PPIH, LSM6",0.0305840876460186,0.00305075150461883,FALSE
+"A549","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.40793,-1.17,0.237,8377,0.791,"PGM1, GYS1, UGT2B17, AGL, HK2, GCK, PGM2, HK1",0.625251653989896,0.101823516502323,FALSE
+"A549","Input","KEGG_STEROID_BIOSYNTHESIS",-0.72831,-2.08,0.0018,8256,0.261,"HSD17B7, CEL, LIPA, MSMO1, SOAT2, DHCR7, FDFT1, CYP27B1, SC5D, DHCR24",2.74472749489669,0.583359492661719,FALSE
+"A549","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.37622,-1.08,0.309,9676,0.702,"HSD11B2, SULT1E1, HSD17B2",0.510041520575165,0.153662887870195,FALSE
+"A549","Input","KEGG_SULFUR_METABOLISM",-0.6033,-1.73,0.0484,9422,0.564,"BPNT1, SULT1E1",1.31515463835559,0.248720896016658,FALSE
+"A549","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.72897,2.12,0.0068,1814,0.304,"C1S, C9, ACTN1, ACTN4, C1R, CD40, C4A, SNRPD3, SNRPB",2.16749108729376,0.517126416391246,FALSE
+"A549","Input","KEGG_TASTE_TRANSDUCTION",-0.433,-1.22,0.196,9776,0.691,"SCNN1A",0.707743928643524,0.160521952625802,FALSE
+"A549","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.72157,-2.05,0.00525,8203,0.214,"MVK, GGPS1, PMVK, IDI1, ACAT2, MVD, HMGCR, FDPS, HMGCS2",2.27984069659404,0.669586226650809,TRUE
+"A549","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.29945,0.88,0.586,1868,0.837,"TGFB2, TGFBR2, TGFBR1, ACVR1, SMAD3, SMAD2, ID1, ZFYVE16, SMURF2, ROCK2, INHBA",0.232102383981909,0.07727454200674,FALSE
+"A549","Input","KEGG_THYROID_CANCER",-0.50713,-1.44,0.0938,6880,0.67,"TCF7L2, MAP2K1, CCDC6, RXRA, RXRB, MAP2K2, BRAF, CTNNB1, NCOA4, KRAS, NRAS, CDH1, MAPK1, MAPK3",1.02779716162094,0.173925197299174,FALSE
+"A549","Input","KEGG_TIGHT_JUNCTION",-0.403,-1.14,0.25,8041,0.671,"KRAS, NRAS, OCLN, PRKCI, PARD6A, AFDN, F11R, CTNNA1, PRKCD, TJAP1, PPP2R1B, AKT1, MYH7, EPB41, PATJ, ACTG1, PRKCZ, EPB41L3, MYH14, MYH7B, HCLS1, TJP3, CRB3, CGN, CLDN11, TJP2, CLDN3, CLDN7, CLDN4, CLDN18",0.602059991327962,0.173277479831008,FALSE
+"A549","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.44005,-1.25,0.19,7315,0.689,"PIK3CD, TLR2, RIPK1, MYD88, MAP2K3, MAPK10, IL6, MAP2K2, RAC1, MAP3K7, PIK3R1, PIK3CA, MAPK14, IFNAR1, NFKBIA, IRAK4, FADD, PIK3CB, CTSK, NFKB1, AKT1, MAPK1, MAP2K7, MAPK3, FOS, TLR3, MAPK12",0.721246399047171,0.161780778092374,FALSE
+"A549","Input","KEGG_TRYPTOPHAN_METABOLISM",0.31298,0.919,0.545,316,0.77,"KYNU, ALDH2, ALDH1B1",0.263603497723358,0.113509274827518,FALSE
+"A549","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.29933,-0.866,0.606,7090,0.778,"MAPK9, PDX1, PIK3CD, MAPK10, PIK3R1, PIK3CA, PRKCD, PIK3CB, MAPK1, HK2, GCK, PRKCZ, MAPK3, HK1",0.217527375833714,0.109020403010311,FALSE
+"A549","Input","KEGG_TYROSINE_METABOLISM",-0.47428,-1.33,0.148,8581,0.63,"LCMT1, MAOB, IL4I1, MIF, ALDH1A3, MAOA, ADH4, ADH7, ADH1C",0.829738284605043,0.200659450546418,FALSE
+"A549","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.51039,-1.47,0.0739,7558,0.873,"NFKBIE, MAP2K2, PAK2, VAV2, GSK3B, RAF1, MAP3K7, PIK3R1, DLG1, KRAS, NRAS, VAV1, PTPRC, PIK3CA, PAK3, MAPK14, NCK2, CBLB, PTPN6, BCL10, NFKBIA, VAV3, PAK1, PIK3CB, NFKB1, AKT1, MAPK1, MAP2K7, MAPK3, PDPK1, CBL, FOS, LCK, PAK5, PAK6, CARD11, NFATC2, MAPK12",1.13135556160517,0.0589857562944303,FALSE
+"A549","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.21024,-0.613,0.955,7832,1,"UBE2Q1, UBE2NL, UBE3A, UBE2L3, UBE4A, CUL7, UBE2D4, FBXO2, UBE2B, CBLB, PML, UBE2K, WWP2, FZR1, UBA6, UBE2C, CBL, RCHY1, UBE2L6, KEAP1, UBA7",0.0199966284162537,0,FALSE
+"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.30756,0.872,0.587,6795,0.837,"BCAT2, PDHA1, PDHB, IARS2, BCAT1, VARS2, LARS2",0.231361898752386,0.07727454200674,FALSE
+"A549","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.37201,-1.06,0.343,6530,0.704,"EHHADH, BCAT1, BCKDHB, HMGCL, HADH, HADHA, PCCB, HMGCS1, DLD, MCCC2, PCCA, ALDH6A1, DBT, ALDH9A1, ACAD8, ACADM, ACAT2, IL4I1, IVD, MCCC1, ABAT, HMGCS2, OXCT1",0.464705879957229,0.152427340857888,FALSE
+"A549","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.47889,1.43,0.0979,1975,0.479,"PPP1R14A, CALD1, MYLK, PLCB4, KCNMA1, PRKCG, PLA2G4A, ITPR1, PPP1R12A, PRKCB, PRKCH, PPP1R12B, ADCY3, ADCY8, GNA13, PRKCQ, PRKCE, NPR2, MYL6, GNAQ, PRKACA, PRKCA, MYL6B, MYH11, ACTA2, ARHGEF1, ROCK2, MYL9, GNA12, PPP1CB",1.00921730819686,0.319664486585437,FALSE
+"A549","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.17061,-0.491,0.998,7555,1,"AQP3, ARHGDIA, CREB3L2, AVP, RAB11B, ARHGDIB",0.000869458712628891,0,FALSE
+"A549","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.3919,-1.13,0.263,7636,0.678,"MAP2K2, RAC1, RAF1, PIK3R1, KRAS, NRAS, PIK3CA, MAPK14, PLCG2, SPHK1, MAPKAPK2, PIK3CB, AKT1, MAPK1, MAPKAPK3, PLA2G12A, MAPK3, NFATC2, PLA2G2A, MAPK12, RAC2",0.580044251510242,0.168770306132937,FALSE
+"A549","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.33882,-0.985,0.432,8257,0.735,"PLCG2, ATP6AP1, ATP6V1C1, ATP6V1E1, ATP6V1B2, ATP6V1F, ERO1A, ATP6V1A, ATP6V1H, ATP6V1D, ACTG1, ATP6V1B1, ATP6V1G1, TJP2",0.364516253185088,0.133712660915805,FALSE
+"A549","Input","KEGG_VIRAL_MYOCARDITIS",-0.39183,-1.12,0.286,8578,0.671,"ICAM1, CASP3, MYH7, ACTG1, MYH14, MYH7B, ITGAL, RAC2",0.543633966870957,0.173277479831008,FALSE
+"A549","Input","KEGG_WNT_SIGNALING_PATHWAY",0.21665,0.637,0.942,1261,0.979,"FZD2, PLCB4, PRKCG, DKK1, NKD2, LRP6, MMP7, PRKCB, FZD7, SMAD3, PPP3R1, SMAD2, PRKACA, PRKCA",0.0259490972071227,0.00921730819686218,FALSE
+"HCC15","Input","KEGG_ABC_TRANSPORTERS",0.70761,2.23,0,705,0.11,"ABCC2, ABCC3, ABCG2, ABCD1, ABCA3, ABCC1, ABCA13, TAP2, ABCB6",Inf,0.958607314841775,TRUE
+"HCC15","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.34599,-1.09,0.315,7526,0.948,"NFKB1, CCND1, PIK3CD, PIK3CB, SOS1, RUNX1, TCF7L1, RAF1, PIK3R2, RUNX1T1, CEBPA, AKT3, PIK3CG, GRB2, SPI1, EIF4EBP1",0.501689446210399,0.0231916626619338,FALSE
+"HCC15","Input","KEGG_ADHERENS_JUNCTION",0.32027,1.04,0.365,926,0.518,"TJP1, PTPRJ, TGFBR2, EGFR, PTPRB, ACTN4, CDH1, IQGAP1, CTNNB1, CTNND1, CTNNA2, CTNNA1, PTPN1, NECTIN2",0.437707135543525,0.285670240254767,FALSE
+"HCC15","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.48884,1.49,0.0917,2462,0.306,"SLC2A1, ACSL3, LEPR, IRS1, PRKAG1, AKT1, ACACB, CHUK, PRKAA1, MAPK8, ACSL1, STK11, PRKAG2, ADIPOR1, MAPK9, PRKAB1, CPT1A, NFKBIB, AKT2, MAPK10, TRAF2, TNFRSF1A, ACSL6",1.03763066432998,0.51427857351842,FALSE
+"HCC15","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.39279,1.24,0.207,1685,0.393,"ASS1, CPS1, GPT, GLUD1, GOT1, ALDH4A1, GFPT1, PPAT, ALDH5A1, GOT2",0.684029654543082,0.405607449624573,FALSE
+"HCC15","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",0.3622,1.14,0.239,478,0.462,"ATP1B1, PIK3R3, SLC9A3R2, IRS1, SFN",0.621602099051862,0.335358024443874,FALSE
+"HCC15","Input","KEGG_ALZHEIMERS_DISEASE",-0.20356,-0.642,0.93,8137,1,"IL1B, UQCRC2, NDUFS4, UQCR10, APP, GSK3B, PLCB2, LRP1, GRIN1, UQCRB, APOE, MME, UQCRFS1, UQCRQ, ATP2A3, LPL, ATP2A1, SNCA",0.0315170514460649,0,FALSE
+"HCC15","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.376,1.2,0.208,2253,0.422,"IARS2, RARS2, SARS2, MARS2, YARS2, NARS2, MTFMT, EARS2, DARS2, FARSB",0.681936665037238,0.374687549038326,FALSE
+"HCC15","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.30031,0.963,0.453,1513,0.575,"UGDH, GNPNAT1, HEXA, PGM3, GNPDA2, PMM2, GALE, GFPT1",0.343901797987168,0.24033215531037,FALSE
+"HCC15","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.343,1.06,0.368,2652,0.522,"MAPK13, BCL2L1, APAF1, MAP2K6, RAB5A, TP53, DERL1, PRPH, PRPH2, PPP3CC, TNFRSF1A, CASP1, TOMM40, BAD, CAT",0.434152181326482,0.282329496997738,FALSE
+"HCC15","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.3367,1.05,0.359,1309,0.523,"B2M, HSPA1L, HSPA2, CTSL, TAP2, LGMN, HSPA6, TAPBP, PSME2, HSPA1A",0.444905551421681,0.281498311132726,FALSE
+"HCC15","Input","KEGG_APOPTOSIS",0.29657,0.93,0.497,1161,0.603,"IL1A, TNFRSF10A, BCL2L1, CAPN2, PIK3R3, CAPN1, AKT1, ENDOD1, CHUK, ATM, BIRC2, APAF1, CASP7",0.303643611266668,0.219682687859849,FALSE
+"HCC15","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.57412,1.84,0.0204,746,0.279,"AKR1C3, GGT1, LTA4H, PTGES, CBR3, CBR1, PTGS2",1.6903698325741,0.554395796726402,FALSE
+"HCC15","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.27417,0.857,0.625,1685,0.69,"ASS1, ODC1, ALDH2, CPS1, MAOA, ALDH3A2, ALDH7A1, GLUD1, GAMT, GOT1, ALDH4A1, ALDH9A1, SAT2, GOT2",0.204119982655925,0.161150909262745,FALSE
+"HCC15","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.45423,1.43,0.115,897,0.303,"ITGA1, PKP2, ITGB5, ACTN4, ITGB4, DMD, CDH2, ITGA6, ITGA3, ITGA2, CTNNB1, DES, CTNNA2, CACNA1C, CTNNA1, LMNA",0.939302159646388,0.518557371497695,FALSE
+"HCC15","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.7467,2.37,0,1421,0.056,"ALDH2, UGDH, ALDH3A2, ALDH7A1, ALDH9A1",Inf,1.2518119729938,TRUE
+"HCC15","Input","KEGG_AXON_GUIDANCE",-0.25068,-0.786,0.716,7564,0.962,"RGS3, ROCK1, RHOA, PLXNB1, NFATC4, EPHA1, NCK2, PAK3, PAK1, NFATC1, SEMA4A, GSK3B, RAC2, DPYSL5, L1CAM, NFATC2, ROBO1, FES, NTNG1, NCK1, RAC3, NTN4, UNC5B, SEMA7A, PLXNA1",0.145086977692144,0.0168249279621871,FALSE
+"HCC15","Input","KEGG_BASAL_CELL_CARCINOMA",0.27273,0.869,0.616,2498,0.683,"FZD6, CTNNB1, APC, TP53, SMO, DVL2, AXIN1, STK36, BMP4",0.210419287835575,0.165579296318467,FALSE
+"HCC15","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.36818,-1.14,0.258,6612,0.89,"TAF1, TAF9B, TAF10, TAF5, TAF6, GTF2F1, TAF9, TAF4, GTF2B, GTF2E1, GTF2E2, TAF12, GTF2F2, TAF7",0.58838029403677,0.0506099933550872,FALSE
+"HCC15","Input","KEGG_BASE_EXCISION_REPAIR",-0.28007,-0.873,0.581,7320,0.905,"APEX1, MBD4, PARP1, POLB, SMUG1, TDG, MPG, NEIL2",0.235823867609669,0.0433514207947967,FALSE
+"HCC15","Input","KEGG_BETA_ALANINE_METABOLISM",0.41599,1.3,0.154,1421,0.366,"ALDH2, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1",0.812479279163537,0.436518914605589,FALSE
+"HCC15","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.40036,-1.25,0.174,8886,0.9,"SCD, FADS2, ELOVL6, SCD5",0.7594507517174,0.0457574905606751,FALSE
+"HCC15","Input","KEGG_BLADDER_CANCER",-0.32802,-1.01,0.414,8344,0.917,"E2F3, RAF1, CDK4, MDM2, MMP2, VEGFA, RB1, CDKN2A",0.382999658879101,0.0376306643299789,FALSE
+"HCC15","Input","KEGG_BUTANOATE_METABOLISM",0.32717,1.01,0.367,1602,0.552,"ALDH2, AACS, ACADS, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1, ALDH5A1",0.435333935747911,0.258060922270801,FALSE
+"HCC15","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.39899,-1.23,0.2,8272,0.79,"NFATC1, GSK3B, CD81, PLCG2, RAF1, BTK, RAC2, PIK3R2, PRKCB, AKT3, VAV3, NFATC2, CD79A, PIK3CG, GRB2, RAC3, PIK3AP1, FCGR2B, INPP5D, CD79B",0.698970004336019,0.102372908709559,FALSE
+"HCC15","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.336,-1.07,0.327,8465,0.925,"PLCG1, PLCG2, TNNC1, PLCB2, PRKCB, RYR1, GRIN1, MYLK, PDGFRB, PDE1C, ATP2A3, PLCZ1, ATP2A1, CAMK4, BST1, SLC8A1",0.485452247339714,0.0338582672609674,FALSE
+"HCC15","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.4178,-1.3,0.151,8212,0.981,"UQCRC2, CACNB3, UQCR10, ATP1B3, TNNC1, UQCRB, UQCRFS1, UQCRQ, TPM2, CACNA2D1, SLC8A1",0.821023052706831,0.0083309926200515,FALSE
+"HCC15","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.39663,1.23,0.19,926,0.398,"CLDN6, ICAM2, CD274, CADM1, CD40, OCLN, CDH1, CD99, CDH2, SDC4, CDH4, ITGA6, NEGR1, ICAM1, CLDN1, MPZ, MPZL1, NECTIN2",0.721246399047171,0.400116927926312,FALSE
+"HCC15","Input","KEGG_CELL_CYCLE",-0.27195,-0.83,0.674,7699,0.923,"PTTG1, CDKN1A, CDC20, CDKN1B, CREBBP, TFDP2, DBF4, GSK3B, E2F3, CHEK2, ZBTB17, E2F4, BUB1, CCND2, ORC6, CDK4, MDM2, SKP2, SMAD4, E2F5, TFDP1, RB1, EP300, CDKN2A",0.17134010346468,0.0347982989740879,FALSE
+"HCC15","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",0.17974,0.568,0.982,1425,0.978,"CXCL8, ARRB1, PIK3R3, STAT1, GNAI1, ADCY9, AKT1, ADCY5, ROCK2, GNG2, CCL13, RASGRP2, CHUK, GNG12, ADCY6, VAV2, SHC1",0.00788851221305034,0.00966114521239857,FALSE
+"HCC15","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.33954,-1.05,0.389,7526,0.943,"NFKB1, BCR, CCND1, PIK3CD, PIK3CB, CDKN1A, CTBP1, CDKN1B, SOS1, MECOM, RUNX1, E2F3, RAF1, PIK3R2, CDK4, MDM2, AKT3, SMAD4, PIK3CG, CBLB, GRB2, RB1, CDKN2A",0.410050398674292,0.0254883072626717,FALSE
+"HCC15","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.46598,1.47,0.0909,1738,0.307,"PC, IDH3G, OGDH, OGDHL, DLAT, CS, IDH3B, FH, IDH3A, SDHC",1.04143611677803,0.512861624522813,FALSE
+"HCC15","Input","KEGG_COLORECTAL_CANCER",-0.19612,-0.607,0.945,6493,1,"TGFB1, CASP3, TGFB2, CYCS, MAPK1, BRAF, PIK3R1, FOS, APPL1, CCND1, PIK3CD, PIK3CB, RHOA, BIRC5, GSK3B, TCF7L1, RAF1, RAC2, PIK3R2, AKT3, SMAD4, PIK3CG, RAC3",0.0245681914907371,0,FALSE
+"HCC15","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.41377,1.3,0.154,1274,0.366,"THBD, PLAUR, MBL2, F2R, C9, PLAU, CFH, SERPINA1, PROC, CD46, CD59, TFPI",0.812479279163537,0.436518914605589,FALSE
+"HCC15","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.29763,0.943,0.486,1685,0.594,"MAT1A, CBS, APIP, GOT1, SDS, LDHA, GOT2",0.313363730737707,0.226213555018806,FALSE
+"HCC15","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.47072,1.48,0.0772,890,0.306,"IL1A, TNFRSF12A, TNFRSF19, TNFRSF21, IFNGR1, IL18, TNFRSF10A, CXCL8, TGFBR2, EGFR, CD40, KIT, LEPR, BMPR1A, IL13RA1, BMPR2, OSMR, CCL13",1.11238269966426,0.51427857351842,FALSE
+"HCC15","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.34526,1.09,0.317,1168,0.512,"ZBP1, IL18, DDX58, CHUK, RIPK3, PYCARD",0.498940737782249,0.290730039024169,FALSE
+"HCC15","Input","KEGG_DILATED_CARDIOMYOPATHY",0.34044,1.04,0.359,897,0.518,"ITGA1, ITGB5, ITGB4, DMD, ITGA6, ITGA3, ITGA2, ADCY9, DES, ADCY5, CACNA1C, LMNA",0.444905551421681,0.285670240254767,FALSE
+"HCC15","Input","KEGG_DNA_REPLICATION",0.3924,1.24,0.202,3223,0.393,"POLD1, LIG1, MCM6, MCM5, MCM3, MCM7, RFC1, POLA1, MCM4, POLE4, POLD3, POLE2, FEN1, POLA2, SSBP1, POLE, PRIM1, MCM2, PRIM2",0.694648630553376,0.405607449624573,FALSE
+"HCC15","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.33996,1.04,0.368,201,0.518,"PIWIL1, EGFR",0.434152181326482,0.285670240254767,FALSE
+"HCC15","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.55855,1.71,0.0468,1069,0.246,"ALDH3A1, GSTM4, GSTM3, GSTM2, CYP3A7, MAOA, ALDH3B1, MGST1",1.32975414692588,0.609064892896621,TRUE
+"HCC15","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.49619,1.55,0.0686,360,0.279,"CES1, CES2, CDA, UPP1, CYP3A7",1.16367588429325,0.554395796726402,FALSE
+"HCC15","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.4732,-1.47,0.101,8261,0.886,"LAMC1, COL6A2, ITGA5, HSPG2, COL2A1, ITGA4, TNXB, COL6A3, TNC, COL3A1, CD47, VTN, FN1, COL6A1, COL5A1, SDC2, COL1A1, ITGB3, THBS3, LAMB1, ITGA7, SV2A, COL4A2, SDC1, COL1A2, ITGB8",0.995678626217357,0.0525662781129492,FALSE
+"HCC15","Input","KEGG_ENDOCYTOSIS",0.34167,1.08,0.316,2148,0.52,"DNM3, EGFR, SMURF1, KIT, HSPA1L, EHD4, ARRB1, SMURF2, HSPA2, F2R, RAB11FIP5, ERBB4, DNM1, RAB11A, WWP1, AP2S1, RAB11FIP2, HSPA6, EHD1, AP2A2, ASAP2, EHD2, RAB5C, NEDD4, PLD2, RAB5A, AP2M1, HSPA1A, RAB31, IQSEC2, CLTC, AP2B1, CLTB, IGF1R, ARF6, EEA1, ITCH, PIP5K1A, HRAS, MVB12B, AP2A1, CHMP2A, EHD3, DAB2, RAB5B, SH3GLB2, USP8",0.500312917381596,0.283996656365201,FALSE
+"HCC15","Input","KEGG_ENDOMETRIAL_CANCER",0.23855,0.74,0.758,813,0.829,"EGFR, CDH1, PIK3R3, CTNNB1, AKT1, CTNNA2, CTNNA1",0.120330794367946,0.0814454694497265,FALSE
+"HCC15","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.37547,1.16,0.247,1160,0.454,"MAPK13, TJP1, CXCL8, EGFR, TCIRG1, ATP6V0D1, ATP6V0A1, CHUK, MAPK8, ATP6V0A2, JUN",0.607303046740334,0.342944147142896,FALSE
+"HCC15","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.264,-0.818,0.693,7470,0.93,"MAP2K7, PIK3CD, PIK3CB, CDKN1A, CDKN1B, SOS1, NCK2, PAK3, PAK1, GAB1, GSK3B, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, AKT3, PIK3CG, NCK1, CBLB, GRB2, EIF4EBP1",0.159266765388193,0.0315170514460649,FALSE
+"HCC15","Input","KEGG_ETHER_LIPID_METABOLISM",0.56003,1.76,0.0394,1505,0.248,"PLPP2, PLPP3, AGPS, LPCAT1, PLD2, PAFAH1B1",1.40450377817443,0.605548319173784,TRUE
+"HCC15","Input","KEGG_FATTY_ACID_METABOLISM",0.49015,1.55,0.0622,1022,0.279,"ALDH2, ECI1, ACSL3, ACADS, ACADSB, ALDH3A2, ALDH7A1, HADHB, ECHS1, EHHADH, ACSL1",1.20620961530918,0.554395796726402,FALSE
+"HCC15","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.34917,-1.08,0.334,7470,0.936,"MAP2K7, MAP2K3, PRKCE, PIK3CD, PIK3CB, PDPK1, SOS1, LCP2, PLCG1, PLCG2, RAF1, BTK, RAC2, PIK3R2, PLA2G12A, PRKCB, AKT3, VAV3, PIK3CG, PRKCD, GRB2, RAC3, INPP5D",0.476253533188435,0.0287241512618947,FALSE
+"HCC15","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.30888,-0.968,0.449,8465,0.968,"PLCG1, PLCG2, RAF1, RAC2, GSN, PIK3R2, PRKCB, AKT3, WASF1, VAV3, DOCK2, PIK3CG, PRKCD, PTPRC, FCGR2B, FCGR2C, INPP5D, MARCKSL1, WASF3",0.347753658996677,0.0141246426916063,FALSE
+"HCC15","Input","KEGG_FOCAL_ADHESION",-0.29831,-0.924,0.513,7572,0.943,"CCND1, PIK3CD, COL11A1, ROCK1, PIK3CB, RHOA, PDPK1, THBS1, LAMB2, TLN1, HGF, SOS1, ACTN3, PAK3, PAK1, LAMC1, GSK3B, COL6A2, ITGA5, COL2A1, RAF1, ITGA4, TNXB, CCND2, RAC2, COL6A3, PIK3R2, TNC, PRKCB, COL3A1, MYLK, PDGFRB, AKT3, VTN, FN1, VAV3, PIK3CG, COL6A1, ACTG1, COL5A1, GRB2, COL1A1, RAC3, VEGFA, ITGB3, THBS3, LAMB1, ITGA7, COL4A2, COL1A2, ITGB8",0.289882634888184,0.0254883072626717,FALSE
+"HCC15","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.40989,-1.27,0.169,7440,0.911,"FPGS, DHFR, ALPG, GCH1, ALPI, ALPP",0.772113295386326,0.0404816230270017,FALSE
+"HCC15","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.31955,-0.989,0.401,8060,0.942,"MPI, PFKFB4, ALDOB, HK2, FBP1, FBP2, ALDOC",0.396855627379818,0.0259490972071227,FALSE
+"HCC15","Input","KEGG_GALACTOSE_METABOLISM",0.30693,0.968,0.447,278,0.58,"PFKP, GLA",0.349692476868064,0.236572006437063,FALSE
+"HCC15","Input","KEGG_GAP_JUNCTION",0.30337,0.98,0.438,711,0.567,"TJP1, TUBB2B, ITPR3, EGFR, GNAI1, ADCY9, ADCY5",0.3585258894959,0.246416941107093,FALSE
+"HCC15","Input","KEGG_GLIOMA",-0.41747,-1.31,0.162,7572,1,"CCND1, PIK3CD, PIK3CB, CDKN1A, SOS1, E2F3, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, CDK4, PDGFRB, MDM2, AKT3, PIK3CG, GRB2, RB1, CDKN2A",0.790484985457369,0,FALSE
+"HCC15","Input","KEGG_GLUTATHIONE_METABOLISM",0.4926,1.53,0.0729,505,0.287,"GCLC, GGT1, GSTM4, GSTM3, ODC1, GSTM2, GCLM, GSR, G6PD",1.13727247168203,0.542118103266008,FALSE
+"HCC15","Input","KEGG_GLYCEROLIPID_METABOLISM",0.43127,1.35,0.129,961,0.341,"PLPP2, GLA, ALDH2, AGPAT3, CEL, PLPP3, GPAT3, ALDH3A2, ALDH7A1, DGKE",0.889410289700751,0.467245621007502,FALSE
+"HCC15","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.33289,1.05,0.36,1184,0.523,"PLPP2, MBOAT7, AGPAT3, PLPP3, GPAT3, GPD2, PTDSS2, DGKE, LPCAT1, PLD2, GNPAT",0.443697499232713,0.281498311132726,FALSE
+"HCC15","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.54594,1.71,0.0394,1176,0.246,"ALAS1, GLDC, CBS, MAOA, SHMT1, GAMT, PHGDH, SDS",1.40450377817443,0.609064892896621,TRUE
+"HCC15","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.35208,1.11,0.286,1802,0.489,"ALDH3A1, PFKP, ALDH2, ALDH3A2, ALDH3B1, ALDH7A1, DLAT, LDHA, ACSS2, ALDH9A1, PKLR, GALM, ENO3",0.543633966870957,0.31069114087638,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.47352,-1.48,0.0732,6273,0.999,"CHPF, CHST14, B3GALT6, CHSY1, UST, CHPF2, B3GAT3, DSE",1.13548891894161,0.000434511774017692,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.31687,1,0.418,134,0.554,"GLCE",0.378823718224965,0.25649023527157,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.28245,0.879,0.554,1373,0.674,"ST3GAL1, B4GAT1",0.25649023527157,0.17134010346468,FALSE
+"HCC15","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.37857,1.16,0.285,2467,0.454,"HEXA, GUSB, GALNS, NAGLU, GNS, IDUA, HGSNAT",0.54515513999149,0.342944147142896,FALSE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.55602,1.76,0.0237,871,0.248,"ST3GAL5, HEXA, ST3GAL1",1.6252516539899,0.605548319173784,TRUE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.64249,2.03,0.013,871,0.159,"GLA, HEXA, ST3GAL1",1.88605664769316,0.798602875679548,TRUE
+"HCC15","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.36335,1.15,0.27,1373,0.454,"ST3GAL4, B4GAT1",0.568636235841013,0.342944147142896,FALSE
+"HCC15","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.27826,-0.88,0.583,7454,0.955,"GPAA1, PIGN, PIGO, PGAP1, PIGU",0.234331445240986,0.0199966284162537,FALSE
+"HCC15","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.26821,0.843,0.64,1213,0.701,"HYI, CS",0.193820026016113,0.154281982033341,FALSE
+"HCC15","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.28335,0.905,0.547,1334,0.641,"MAPK13, ITPR3, EGFR, ADCY9, ADCY5, CACNA1C, MAPK8, JUN, PLD2, MAP2K6, ITPR2, ADCY6",0.262012673666569,0.193141970481183,FALSE
+"HCC15","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.20457,0.631,0.943,2498,0.953,"CSNK1G2, CSNK1G3, SMO, PRKACB, RAB23, CSNK1A1, STK36, BMP4",0.0254883072626717,0.0209070993616736,FALSE
+"HCC15","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.40366,1.26,0.183,684,0.384,"ITGA1, IL1A, KIT, CD14, ITGA6, ITGA3, ITGA2, CD9",0.737548910269571,0.415668775632469,FALSE
+"HCC15","Input","KEGG_HISTIDINE_METABOLISM",0.5574,1.76,0.039,829,0.248,"ALDH3A1, AMDHD1, ALDH2, MAOA, ALDH3A2, ALDH3B1, ALDH7A1",1.4089353929735,0.605548319173784,TRUE
+"HCC15","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.22548,-0.697,0.868,6332,1,"RAD54L, TOP3B, BRCA2, RAD51, POLD4, RAD51B, XRCC3, SEM1, RAD52, RAD54B",0.0614802748235081,0,FALSE
+"HCC15","Input","KEGG_HUNTINGTONS_DISEASE",-0.19488,-0.602,0.948,6353,1,"POLR2D, ATP5PO, CREB5, COX5B, ATP5F1E, GPX1, CASP3, HDAC1, CYCS, ATP5PD, NDUFV2, IFT57, POLR2E, NDUFA7, DLG4, COX7A2L, NDUFAB1, PLCB1, NDUFS6, COX6C, POLR2L, HDAC2, NDUFA6, NDUFS5, HAP1, POLR2C, CREB1, DNAL4, POLR2G, NRF1, TAF4, POLR2J, CREBBP, PPID, UQCRC2, NDUFS4, UQCR10, POLR2I, POLR2K, SP1, POLR2H, PLCB2, GRIN1, UQCRB, UQCRFS1, UQCRQ, POLR2F, DNAH3, REST, EP300",0.0231916626619338,0,FALSE
+"HCC15","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.31101,0.992,0.434,1010,0.561,"ITGA1, ITGB5, ITGB4, DMD, ITGA6, ITGA3, ITGA2, PRKAG1, DES, CACNA1C, LMNA, PRKAA1",0.362510270487489,0.251037138743839,FALSE
+"HCC15","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.33281,-1.03,0.387,7590,0.894,"PIK3CD, PI4KB, PIK3CB, INPP5B, PLCG1, PLCG2, PIP4K2A, IMPA2, PLCB2, INPP4B, PIK3CG, ALDH6A1, PLCZ1",0.412289034981089,0.0486624812040823,FALSE
+"HCC15","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.19482,-0.604,0.947,7590,1,"PIK3CD, PIK3CB, PDPK1, INSR, EIF4E, SOS1, FOXO1, GSK3B, HK2, FBP1, RAF1, PIK3R2, FBP2, AKT3, PIK3CG, CBLB, GRB2, PRKAR2B, INPP5D, EIF4EBP1",0.0236500209967266,0,FALSE
+"HCC15","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.59889,-1.82,0.0303,8608,0.558,"ITGA4, IL6, TNFRSF13C",1.5185573714977,0.253365801062421,FALSE
+"HCC15","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",0.26103,0.818,0.676,1056,0.723,"IFNGR1, BCL2L1, PIK3R3, LEPR, STAT1, AKT1, IL13RA1, OSMR, IRF9, SPRED1, JAK1",0.170053304058364,0.140861702705469,FALSE
+"HCC15","Input","KEGG_LEISHMANIA_INFECTION",0.33992,1.07,0.311,1160,0.528,"MAPK13, IL1A, IFNGR1, STAT1, PTGS2, JAK1, JUN",0.507239610973163,0.277366077466188,FALSE
+"HCC15","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.30166,0.951,0.484,885,0.587,"MAPK13, CLDN6, OCLN, ACTN4, CD99, PIK3R3, GNAI1, ICAM1, CTNNB1, CTNND1, CLDN1, ROCK2, CTNNA2, CTNNA1, RASSF5",0.315154638355588,0.231361898752386,FALSE
+"HCC15","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.68417,2.16,0.0111,1421,0.128,"ALDH2, ALDH3A2, ALDH7A1, ECHS1, EHHADH, ALDH9A1",1.95467702121334,0.892790030352132,TRUE
+"HCC15","Input","KEGG_LONG_TERM_DEPRESSION",-0.26318,-0.804,0.683,8559,0.941,"RAF1, GNAO1, PLCB2, PLA2G12A, PRKCB, RYR1, PRKG1",0.165579296318467,0.0264103765727431,FALSE
+"HCC15","Input","KEGG_LONG_TERM_POTENTIATION",-0.27297,-0.83,0.63,8559,0.923,"RAF1, PLCB2, PRKCB, GRIN1, CAMK4, EP300",0.200659450546418,0.0347982989740879,FALSE
+"HCC15","Input","KEGG_LYSINE_DEGRADATION",-0.29447,-0.907,0.521,7341,0.935,"KMT5B, SETD7, AASS, ALDH1B1, NSD1, DOT1L, NSD3, PLOD3, GCDH, SETD2, SETDB2, PLOD1, PLOD2, SETMAR, NSD2",0.283162276700476,0.0291883891274822,FALSE
+"HCC15","Input","KEGG_LYSOSOME",0.42822,1.36,0.117,1901,0.346,"AGA, SLC11A2, TCIRG1, CTSV, GLA, CLN3, FUCA1, AP1S3, SLC17A5, SORT1, LIPA, ATP6V0D1, LAPTM4A, CTSL, LGMN, CTSZ, HEXA, ATP6V0A1, AP1S2, GUSB, GALNS, CD63, ATP6V0A2, PPT2, CTSF, AP1M1, CLTC, CLTB, NAGLU, IGF2R, AP4M1, NAGPA, NPC2, ABCA2, AP1G1, AP4E1, GNS, MANBA, ACP2, ATP6AP1",0.931814138253838,0.460923901207223,FALSE
+"HCC15","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.24266,0.766,0.735,1309,0.794,"MAPK13, IL1A, TGFBR2, EGFR, FLNB, HSPA1L, CD14, RELB, ARRB1, HSPA2, MOS, RRAS2, NFKB2, RPS6KA5, AKT1, DDIT3, CACNA1C, PPP5C, HSPA6, RRAS, CDC25B, RASGRP2, CHUK, MAPK8, JUN, GNG12, MAP2K6, FLNC, HSPA1A",0.133712660915805,0.100179497572904,FALSE
+"HCC15","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.64114,2.03,0.0102,1549,0.159,"PDX1, PKLR",1.99139982823808,0.798602875679548,TRUE
+"HCC15","Input","KEGG_MELANOGENESIS",-0.28721,-0.907,0.497,8294,0.935,"GSK3B, KITLG, TCF7L1, RAF1, GNAO1, PLCB2, PRKCB, WNT10A, WNT5A, MITF, EP300",0.303643611266668,0.0291883891274822,FALSE
+"HCC15","Input","KEGG_MELANOMA",-0.45576,-1.41,0.123,7572,0.839,"CCND1, PIK3CD, PIK3CB, CDKN1A, FGFR1, HGF, E2F3, RAF1, PIK3R2, CDK4, PDGFRB, MDM2, AKT3, FGF13, FGF2, PIK3CG, MITF, FGF1, RB1, CDKN2A",0.910094888560602,0.0762380391712997,FALSE
+"HCC15","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.66437,2.11,0.0128,781,0.14,"ALDH3A1, CYP2S1, AKR1C3, GSTM4, EPHX1, GSTM3, GSTM2, CYP3A7, AKR1C1, ALDH3B1",1.89279003035213,0.853871964321762,TRUE
+"HCC15","Input","KEGG_MISMATCH_REPAIR",0.48924,1.55,0.0738,2364,0.279,"MSH6, MSH2, POLD1, PMS2, LIG1, MLH1, RFC1, MSH3, POLD3",1.13194363817696,0.554395796726402,FALSE
+"HCC15","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.27939,-0.871,0.587,7525,0.89,"CAB39L, PIK3CD, PIK3CB, PDPK1, EIF4E, PIK3R2, AKT3, PIK3CG, VEGFA, EIF4EBP1",0.231361898752386,0.0506099933550872,FALSE
+"HCC15","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.27514,0.865,0.561,710,0.683,"IFNGR1, SYK, ICAM2, TNFRSF10A, ULBP3, PIK3R3, MICB, ICAM1, RAET1L, ULBP2",0.251037138743839,0.165579296318467,FALSE
+"HCC15","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.34275,1.06,0.301,1517,0.522,"LEPR, F2R, P2RX4, HCRTR1, NR3C1, TACR1",0.521433504406157,0.282329496997738,FALSE
+"HCC15","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.19855,-0.604,0.94,7383,1,"YWHAB, MAP2K7, NFKB1, MAP3K5, PIK3CD, PIK3CB, RHOA, PDPK1, FOXO3, SOS1, GAB1, GSK3B, PLCG1, PLCG2, RAF1, PIK3R2, AKT3, MAGED1, PIK3CG, PRKCD, GRB2, CAMK4, ARHGDIB",0.0268721464003014,0,FALSE
+"HCC15","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.52387,1.65,0.0495,1098,0.24,"NNMT, QPRT, NAMPT, NT5E, NNT, NT5C2",1.30539480106643,0.619788758288394,TRUE
+"HCC15","Input","KEGG_NITROGEN_METABOLISM",-0.39534,-1.21,0.215,9360,0.795,"GLUL, CA8, CA2",0.667561540084395,0.0996328713435297,FALSE
+"HCC15","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.33409,1.06,0.345,1220,0.522,"MAPK13, IL18, CXCL8, CCL13, CHUK, MAPK8, BIRC2, PYCARD, CASP5",0.462180904926726,0.282329496997738,FALSE
+"HCC15","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.57268,1.78,0.0323,1970,0.288,"RAD50, PRKDC, NHEJ1, XRCC6, XRCC5, MRE11",1.4907974776689,0.540607512240769,FALSE
+"HCC15","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.44561,-1.42,0.105,7572,0.913,"CCND1, PIK3CD, PIK3CB, PDPK1, FOXO3, SOS1, E2F3, PLCG1, PLCG2, RAF1, PIK3R2, PRKCB, CDK4, AKT3, PIK3CG, GRB2, STK4, RB1, FHIT, CDKN2A",0.978810700930062,0.039529222465701,FALSE
+"HCC15","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.39566,-1.24,0.205,6513,0.814,"HDAC1, MAML1, NUMBL, CIR1, NCSTN, RBPJ, HDAC2, SNW1, DVL3, CTBP1, NCOR2, JAG1, CREBBP, NOTCH3, DTX3, EP300",0.688246138944246,0.0893755951107988,FALSE
+"HCC15","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.46661,1.46,0.0869,2100,0.308,"CUL4B, DDB2, ERCC8, GTF2H3, ERCC2, GTF2H4, ERCC3, POLD1, GTF2H2, CDK7, LIG1, CCNH, DDB1, GTF2H1, RFC1, POLE4, ERCC4",1.06098022355133,0.511449283499556,FALSE
+"HCC15","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.18783,-0.581,0.972,6759,1,"STT3B, B4GALT3, ALG11, FUT8, DPM3, ALG10, ALG10B, DAD1, MGAT3, MAN1A2, MAN1A1, ST6GAL1",0.0123337350737254,0,FALSE
+"HCC15","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.35419,-1.1,0.3,8784,0.964,"PRKG1, PDE1C",0.522878745280338,0.0159229660971692,FALSE
+"HCC15","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.26886,0.848,0.625,2649,0.699,"SHMT1, MTHFS, AMT, MTFMT, ATIC, GART",0.204119982655925,0.155522824254319,FALSE
+"HCC15","Input","KEGG_OOCYTE_MEIOSIS",0.26817,0.821,0.678,2127,0.725,"ITPR3, MOS, ADCY9, ADCY5, AR, CCNB1, ITPR2, ADCY6, PPP2R5D, CDC27, IGF1R, YWHAZ, CDC23, ANAPC7, PRKACB, ANAPC4, CDC16, PPP3CC, ITPR1, ANAPC2, ESPL1",0.168770306132937,0.139661993429006,FALSE
+"HCC15","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.56931,1.79,0.0259,743,0.303,"AGA, FUCA2, FUCA1, MAN2B2, HEXA",1.58670023591875,0.518557371497695,FALSE
+"HCC15","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",-0.1544,-0.483,1,6739,0.997,"ATP5PD, NDUFV2, ATP6V1D, ATP5MG, NDUFA7, COX7A2L, NDUFAB1, NDUFS6, COX6C, NDUFA6, COX11, NDUFS5, ATP6V1F, PPA2, ATP5ME, UQCRC2, NDUFS4, UQCR10, COX17, ATP6V1G1, ATP6V1E1, UQCRB, UQCRFS1, UQCRQ",0,0.00130484168834428,FALSE
+"HCC15","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.45865,1.45,0.107,1429,0.3,"ST3GAL1, GALNT5, C1GALT1, GALNT13, GALNT15, GALNT7, B3GNT6, C1GALT1C1",0.97061622231479,0.522878745280338,FALSE
+"HCC15","Input","KEGG_P53_SIGNALING_PATHWAY",-0.24114,-0.749,0.769,6416,1,"TNFRSF10B, TP53I3, CASP3, CYCS, CHEK1, GTSE1, COP1, PPM1D, SERPINE1, CD82, CCND1, CDKN1A, THBS1, RCHY1, CHEK2, CCND2, CDK4, MDM2, IGFBP3, CDKN2A",0.114073660198569,0,FALSE
+"HCC15","Input","KEGG_PANCREATIC_CANCER",-0.28514,-0.887,0.559,8553,0.962,"ARHGEF6, RAF1, RAC2, PIK3R2, CDK4, AKT3, SMAD4, PIK3CG, RAC3, VEGFA, RB1, CDKN2A",0.252588192113577,0.0168249279621871,FALSE
+"HCC15","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",0.54978,1.7,0.054,1555,0.243,"BCAT1, BCAT2, PPCS, COASY",1.26760624017703,0.614393726401688,FALSE
+"HCC15","Input","KEGG_PARKINSONS_DISEASE",-0.16333,-0.493,0.994,8189,1,"PPID, UQCRC2, NDUFS4, UQCR10, UBE2L3, UBE2G1, UQCRB, UQCRFS1, UQCRQ, SNCA",0.00261361560268669,0,FALSE
+"HCC15","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",0.34997,1.11,0.304,729,0.489,"TUBB2B, OCLN, CDH1, CD14, CTNNB1, ARPC1A, CLDN1, ROCK2",0.517126416391246,0.31069114087638,FALSE
+"HCC15","Input","KEGG_PATHWAYS_IN_CANCER",-0.27189,-0.843,0.619,7526,0.934,"NFKB1, BCR, DVL3, CCND1, PIK3CD, PIK3CB, CDKN1A, RHOA, CTBP1, FGFR1, LAMB2, CDKN1B, BIRC5, HGF, SOS1, ARNT, CREBBP, MECOM, FOXO1, PIAS1, RUNX1, CKS1B, LAMC1, GSK3B, E2F3, KITLG, TCF7L1, PLCG1, PLCG2, PIAS4, RAF1, RAC2, PIK3R2, PRKCB, RUNX1T1, CDK4, PDGFRB, MDM2, PIAS2, CEBPA, IL6, AKT3, SKP2, WNT10A, SMAD4, WNT5A, FN1, PAX8, FGF13, FGF2, PIK3CG, MMP2, CBLB, GRB2, RAC3, VEGFA, MAX, STK4, LAMB1, SPI1, COL4A2, MITF, FGF1, RB1, EP300, CDKN2A",0.208309350979882,0.0296531237699066,FALSE
+"HCC15","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.42385,1.35,0.126,973,0.341,"UGDH, GUSB",0.899629454882437,0.467245621007502,FALSE
+"HCC15","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.31498,1.01,0.394,505,0.552,"PFKP, TALDO1, RBKS, G6PD",0.404503778174426,0.258060922270801,FALSE
+"HCC15","Input","KEGG_PEROXISOME",0.53609,1.67,0.0353,2653,0.244,"SLC27A2, ABCD1, PECR, DECR2, ACSL3, PEX16, AMACR, NUDT19, PEX3, CROT, MPV17, EHHADH, ACSL1, PXMP4, AGPS, PEX1, GNPAT, PEX6, FAR1, PEX10, PRDX1, SCP2, GSTK1, PEX11B, SLC25A17, ECI2, PEX13, ACOX1, DHRS4, ACSL6, ABCD3, PHYH, CAT, CRAT",1.45222529461218,0.612610173661271,TRUE
+"HCC15","Input","KEGG_PHENYLALANINE_METABOLISM",0.55262,1.75,0.0313,1123,0.241,"ALDH3A1, MAOA, ALDH3B1, GOT1",1.50445566245355,0.617982957425132,TRUE
+"HCC15","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.28458,-0.875,0.574,7590,0.922,"PIK3CD, PI4KB, PIK3CB, DGKD, INPP5B, CDS1, PLCG1, DGKH, PLCG2, PIP4K2A, PIK3R2, IMPA2, PLCB2, PRKCB, INPP4B, PIK3CG, PLCZ1, INPP5D",0.241088107602027,0.0352690789463706,FALSE
+"HCC15","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.45006,1.41,0.121,2433,0.316,"BLVRB, BLVRA, ALAS1, HMOX2, GUSB, HMBS, COX15, PPOX, EARS2, FECH, FTH1",0.91721462968355,0.500312917381596,FALSE
+"HCC15","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.30026,-0.927,0.51,8886,0.962,"SCD, APOC3, ACSL4, LPL, FADS2, PLTP, SCD5",0.292429823902064,0.0168249279621871,FALSE
+"HCC15","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.60596,-1.9,0.0189,8612,0.611,"BTK, RFX5, CD79A, RFXANK, PTPRC, RFXAP, TNFRSF13C",1.72353819582676,0.213958789757446,FALSE
+"HCC15","Input","KEGG_PRION_DISEASES",0.28477,0.883,0.552,561,0.674,"IL1A, C9",0.258060922270801,0.17134010346468,FALSE
+"HCC15","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.37195,1.18,0.208,2398,0.44,"MAPK13, FZR1, PIK3R3, MOS, GNAI1, ADCY9, AKT1, ADCY5, CDC25B, MAPK8, CCNB1, ADCY6, CDC27, IGF1R, CDC23, ANAPC7, PRKACB, ANAPC4, CDC16, GNAI3, MAPK9, ANAPC2, AKT2, MAPK10, PKMYT1, HSP90AB1",0.681936665037238,0.356547323513813,FALSE
+"HCC15","Input","KEGG_PROPANOATE_METABOLISM",0.41893,1.28,0.17,1421,0.367,"ALDH2, MCEE, ACACA, ALDH3A2, ACACB, ALDH7A1, ECHS1, EHHADH, LDHA, ACSS2, ALDH9A1",0.769551078621726,0.435333935747911,FALSE
+"HCC15","Input","KEGG_PROSTATE_CANCER",-0.37041,-1.16,0.252,7418,0.883,"HSP90B1, NFKB1, CCND1, PIK3CD, CREB1, PIK3CB, CDKN1A, PDPK1, FGFR1, CDKN1B, SOS1, CREBBP, FOXO1, GSK3B, E2F3, TCF7L1, RAF1, PIK3R2, PDGFRB, MDM2, AKT3, PIK3CG, GRB2, RB1, EP300",0.598599459218456,0.0540392964224314,FALSE
+"HCC15","Input","KEGG_PROTEASOME",0.30995,1,0.395,3713,0.554,"PSMB8, PSME2, PSME1, PSMD1, PSMD3, PSMD12, PSMD11, PSME4, PSMB2, PSMD6, PSMA6, PSMB1, PSMB5, PSMB4, PSMA4, PSMD13, PSMC3, PSMA2, PSMC5, PSMC4, PSMD2, PSMA7, PSMA3, PSMC2, PSMA5",0.40340290437354,0.25649023527157,FALSE
+"HCC15","Input","KEGG_PROTEIN_EXPORT",0.2489,0.766,0.74,2587,0.794,"SEC63, SEC11A, SRPRA, SPCS2, SRP68, SRP14, SRP72, SRP54",0.130768280269024,0.100179497572904,FALSE
+"HCC15","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.40714,-1.24,0.198,8380,0.814,"ATP1B3, SLC4A4, SLC38A3, CA2",0.703334809738469,0.0893755951107988,FALSE
+"HCC15","Input","KEGG_PURINE_METABOLISM",-0.17481,-0.554,0.992,6682,1,"AMPD2, APRT, PAICS, NPR2, POLD4, POLR2E, NT5C, NUDT9, PNP, POLR2L, GMPS, ITPA, NUDT2, PRPS2, PDE3B, POLR2C, PDE5A, IMPDH1, PRUNE1, POLR2G, ENTPD6, POLR2J, CANT1, NT5C3A, POLR2I, POLR2K, DCK, POLR2H, POLR3G, PDE1C, IMPDH2, POLR2F, FHIT, PDE2A",0.00348832784582135,0,FALSE
+"HCC15","Input","KEGG_PYRIMIDINE_METABOLISM",-0.19577,-0.604,0.953,6792,1,"POLD4, POLR2E, NT5C, PNP, POLR2L, UCKL1, ITPA, NUDT2, POLR2C, POLR2G, UPRT, ENTPD6, POLR2J, CANT1, NT5C3A, POLR2I, TYMS, POLR2K, DCK, POLR2H, UCK2, POLR3G, POLR2F, TXNRD2",0.0209070993616736,0,FALSE
+"HCC15","Input","KEGG_PYRUVATE_METABOLISM",0.53627,1.67,0.0438,1549,0.244,"ME1, ME3, GLO1, ALDH2, PC, ACACA, ALDH3A2, ACACB, ALDH7A1, DLAT, LDHA, ACSS2, ALDH9A1, PKLR",1.3585258894959,0.612610173661271,TRUE
+"HCC15","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.24873,0.77,0.742,612,0.803,"ITGA1, IQGAP2, EGFR, ITGB5, CFL2, ACTN4, ITGB4, CD14, ITGA6, PIK3R3, ITGA3, IQGAP1, ITGA2, RDX, F2R, MOS, RRAS2, ARPC1A, GNA13",0.129596094720973,0.095284454721319,FALSE
+"HCC15","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.18543,-0.564,0.985,6494,1,"PIK3C3, PIK3R4, GABARAPL2, ATG4B, ATG3",0.00656376950238827,0,FALSE
+"HCC15","Input","KEGG_RENAL_CELL_CARCINOMA",-0.28262,-0.877,0.575,7590,0.939,"PIK3CD, PIK3CB, HGF, SOS1, ARNT, CREBBP, PAK3, PAK1, GAB1, RAF1, PIK3R2, AKT3, PIK3CG, GRB2, VEGFA, EP300",0.24033215531037,0.0273344077338891,FALSE
+"HCC15","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.66735,-2.06,0.00748,7871,0.556,"CTSG, ACE, MME, ANPEP, CPA3, CTSA",2.12609840213554,0.254925208417942,FALSE
+"HCC15","Input","KEGG_RETINOL_METABOLISM",0.4217,1.31,0.161,715,0.37,"CYP3A7, RETSAT, ALDH1A1",0.79317412396815,0.431798275933005,FALSE
+"HCC15","Input","KEGG_RIBOFLAVIN_METABOLISM",0.41018,1.28,0.173,2858,0.367,"RFK, ACP2, FLAD1, MTMR2",0.761953896871205,0.435333935747911,FALSE
+"HCC15","Input","KEGG_RIBOSOME",0.513,1.65,0.039,2751,0.24,"RPL26L1, RPL37, RPL19, RPS4Y1, RPL34, RPS6, RPL15, RPL36A, RPL36AL, RPL26, RPS13, RPL37A, RPS11, RPL24, RSL24D1, RPL27A, RPS18, RPL7, RPL35, RPL36, RPS24, RPL13A, RPS7, RPS16, RPS26, RPL6, RPL18A, RPL27, RPL18, RPS8, FAU, RPL3, RPS3A, RPL21, RPS2, RPL32, RPL9, RPL8, RPL10A, RPL28, RPS10, RPS3, RPL35A, RPS9, RPS15A, RPS23, RPL29, RPL5, RPL4, RPS20, RPL14, RPS4X, RPL38, RPL31, RPL23A, RPL7A",1.4089353929735,0.619788758288394,TRUE
+"HCC15","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.44128,1.36,0.13,3008,0.346,"MAPK13, IFIH1, ISG15, CXCL8, DDX58, NLRX1, CHUK, MAPK8, CYLD, MAPK9, NFKBIB, RIPK1, MAPK10, ATG5, CASP8, TANK, TRAF2, PIN1, IRF3, RELA, TRADD, CXCL10, CASP10, TKFC, DDX3X",0.886056647693163,0.460923901207223,FALSE
+"HCC15","Input","KEGG_RNA_DEGRADATION",-0.18615,-0.578,0.98,5585,1,"CNOT8, EXOSC4, CNOT9, EXOSC6, LSM3, PAPOLG, CNOT6, CNOT2, XRN1, EDC3, CNOT3, ZCCHC7, LSM7, CNOT4, LSM8, MPHOSPH6, LSM2, LSM4, DCP1A, LSM6, DCP1B, LSM1, C1D, LSM5",0.00877392430750515,0,FALSE
+"HCC15","Input","KEGG_RNA_POLYMERASE",-0.49911,-1.54,0.0702,5378,0.981,"POLR1B, POLR2B, POLR3K, POLR3D, POLR3F, POLR1C, POLR1D, POLR2D, POLR3H, POLR2E, POLR2L, POLR2C, POLR2G, POLR2J, POLR2I, POLR2K, POLR2H, POLR3G, POLR2F",1.15366288787019,0.0083309926200515,FALSE
+"HCC15","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.46946,1.44,0.101,587,0.302,"GGT1, PAPSS2, MAT1A, CBS",0.995678626217357,0.519993057042849,FALSE
+"HCC15","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.31449,-0.96,0.487,7083,0.931,"LAMA1, LAMA5, LAMA3, LAMA4, TRAF4, NFKB1, CCND1, PIK3CD, PIK3CB, LAMB2, CDKN1B, PIAS1, CKS1B, LAMC1, E2F3, PIAS4, PIK3R2, CDK4, PIAS2, AKT3, SKP2, FN1, PIK3CG, MAX, LAMB1, COL4A2, RB1, FHIT",0.312471038785366,0.0310503190186574,FALSE
+"HCC15","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.52043,1.62,0.0598,1679,0.255,"STX3, VAMP7, VAMP8, STX5, VTI1A, VAMP2, STX12, VAMP3, STX4, STX7, BET1, YKT6, SNAP23, GOSR1",1.22329881601159,0.593459819566045,FALSE
+"HCC15","Input","KEGG_SPHINGOLIPID_METABOLISM",0.47522,1.5,0.0896,482,0.307,"PLPP2, UGCG, GLA, SGPL1, PLPP3",1.04769199033787,0.512861624522813,FALSE
+"HCC15","Input","KEGG_SPLICEOSOME",-0.24176,-0.734,0.774,5674,0.992,"SRSF4, MAGOHB, SRSF9, DDX5, ALYREF, DHX8, THOC3, NCBP2, SF3B4, SNRNP40, HNRNPM, SF3A1, LSM3, PPIH, PPIE, HNRNPA1, SLU7, SF3B5, SNU13, SRSF2, PCBP1, U2SURP, HNRNPA3, PRPF4, TXNL4A, SRSF10, SF3B6, SRSF5, LSM7, HNRNPC, SNRPC, SRSF3, CCDC12, SF3A2, SMNDC1, SNW1, RBM8A, LSM8, SNRPA1, SART1, LSM2, SRSF1, LSM4, PRPF18, LSM6, RBM17, SF3B2, SNRPB, ZMAT2, SNRPG, CWC15, PHF5A, ISY1, PRPF40B, SYF2, LSM5",0.111259039317107,0.00348832784582135,FALSE
+"HCC15","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.41088,1.29,0.157,973,0.37,"PGM2L1, UGDH, GUSB",0.804100347590766,0.431798275933005,FALSE
+"HCC15","Input","KEGG_STEROID_BIOSYNTHESIS",-0.41751,-1.28,0.177,8601,0.956,"SQLE, MSMO1, FDFT1, CYP51A1",0.752026733638193,0.0195421077238999,FALSE
+"HCC15","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.50366,1.58,0.0605,560,0.283,"AKR1C3, CYP21A2, CYP3A7, AKR1C1",1.21824462534753,0.54821356447571,FALSE
+"HCC15","Input","KEGG_SULFUR_METABOLISM",0.87387,2.74,0,234,0.004,"SULT1A3, PAPSS2, SULT1A1",Inf,2.39794000867204,TRUE
+"HCC15","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",-0.30277,-0.945,0.478,7662,0.943,"C3, CTSG, SNRPB, ACTN3, ELANE, C4A, FCGR2B, FCGR2C",0.320572103387881,0.0254883072626717,FALSE
+"HCC15","Input","KEGG_TASTE_TRANSDUCTION",0.45887,1.45,0.0789,1816,0.3,"ITPR3, ADCY6, PRKACB, KCNB1",1.10292299679058,0.522878745280338,FALSE
+"HCC15","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.24242,-0.751,0.781,7277,1,"HMGCR, PMVK, HMGCS1",0.1073489661227,0,FALSE
+"HCC15","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.33064,-1.04,0.355,8504,0.935,"E2F4, SP1, AMH, SMAD4, ID3, E2F5, TFDP1, LTBP1, THBS3, DCN, EP300",0.449771646944906,0.0291883891274822,FALSE
+"HCC15","Input","KEGG_THYROID_CANCER",0.21511,0.683,0.877,567,0.901,"CDH1, CTNNB1",0.0570004066339595,0.045275209020937,FALSE
+"HCC15","Input","KEGG_TIGHT_JUNCTION",0.30445,0.967,0.44,888,0.575,"CLDN6, TJP1, OCLN, ACTN4, TJP2, EPB41L3, GNAI1, RRAS2, CTNNB1, SPTAN1, AKT1, CLDN1, CTNNA2, CTNNA1, LLGL2, RRAS",0.356547323513813,0.24033215531037,FALSE
+"HCC15","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.31747,0.982,0.409,1198,0.57,"MAPK13, CXCL8, CD40, CD14, PIK3R3, STAT1, AKT1, CHUK, MAPK8, JUN, MAP2K6",0.388276691992658,0.244125144327509,FALSE
+"HCC15","Input","KEGG_TRYPTOPHAN_METABOLISM",0.59759,1.88,0.0215,1016,0.263,"KYNU, ALDH2, MAOA, OGDH, ALDH3A2, ALDH7A1, ECHS1, OGDHL, EHHADH",1.66756154008439,0.580044251510242,FALSE
+"HCC15","Input","KEGG_TYPE_II_DIABETES_MELLITUS",0.2252,0.707,0.855,1012,0.874,"PIK3R3, IRS1, CACNA1C, PDX1, MAPK8",0.0680338852718274,0.058488567365597,FALSE
+"HCC15","Input","KEGG_TYPE_I_DIABETES_MELLITUS",-0.56543,-1.74,0.0321,9482,0.576,"CPE, ICA1",1.49349496759513,0.239577516576788,FALSE
+"HCC15","Input","KEGG_TYROSINE_METABOLISM",0.42033,1.33,0.143,1123,0.356,"ALDH3A1, FAH, MAOA, ALDH3B1, GOT1",0.844663962534938,0.448550002027125,FALSE
+"HCC15","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31141,-0.967,0.438,7470,0.941,"MAP2K7, NFKB1, PIK3CD, PIK3CB, RHOA, PDPK1, NFATC4, SOS1, NCK2, LCP2, PAK3, PRKCQ, PAK1, NFATC1, GSK3B, PLCG1, RAF1, PIK3R2, CDK4, AKT3, VAV3, NFATC2, PIK3CG, GRAP2, NCK1, CBLB, GRB2, PTPRC",0.3585258894959,0.0264103765727431,FALSE
+"HCC15","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.1932,0.603,0.961,2072,0.967,"MID1, SMURF1, FZR1, PML, CUL4B, SMURF2, DDB2, ERCC8, WWP2, WWP1, BIRC2, NEDD4, CDC27, UBE4A, UBE2H, STUB1, CDC23, ITCH, ANAPC7, ANAPC4, CDC16, SAE1, DDB1, CUL5, ANAPC2, HUWE1, UBE3B",0.0172766123314547,0.0145735259169983,FALSE
+"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.74502,2.37,0.00222,518,0.056,"BCAT1, BCAT2, IARS2",2.65364702554936,1.2518119729938,TRUE
+"HCC15","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.37736,1.2,0.22,1150,0.422,"ALDH2, BCAT1, BCAT2, ACADS, MCEE, ACADSB, ALDH3A2, ALDH7A1, HADHB, ECHS1, EHHADH, AUH",0.657577319177794,0.374687549038326,FALSE
+"HCC15","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",0.29982,0.937,0.495,1432,0.598,"KCNMA1, ITPR3, ADCY9, GNA13, ADCY5, ROCK2, CACNA1C, ARHGEF11, CALD1, NPR1, ITPR2, ADCY6, ARHGEF1, MYH11",0.305394801066431,0.223298816011589,FALSE
+"HCC15","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.35858,1.15,0.271,2349,0.454,"ADCY9, DYNC1LI2, RAB11A, VAMP2, DYNC1H1, RAB5C, STX4, RAB5A, ADCY6, PRKACB, DYNLL2, RAB5B, DCTN1, NSF, DYNC1I1",0.567030709125594,0.342944147142896,FALSE
+"HCC15","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.32366,-1.03,0.388,7590,0.894,"PIK3CD, PIK3CB, SH2D2A, NFATC4, NFATC1, PLCG1, PLCG2, RAF1, RAC2, PIK3R2, PLA2G12A, PRKCB, HSPB1, AKT3, NFATC2, PIK3CG, RAC3, VEGFA",0.411168274405793,0.0486624812040823,FALSE
+"HCC15","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.43625,1.36,0.126,1019,0.346,"TJP1, TCIRG1, TJP2, ERO1A, SLC12A2, ATP6V0D1, ADCY9, ATP6V0A1, KDELR3, ATP6V0A2",0.899629454882437,0.460923901207223,FALSE
+"HCC15","Input","KEGG_VIRAL_MYOCARDITIS",0.27096,0.84,0.595,519,0.699,"CD40, DMD, CXADR, ICAM1",0.22548303427145,0.155522824254319,FALSE
+"HCC15","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.24023,-0.747,0.782,7533,0.985,"DVL3, CCND1, SFRP1, ROCK1, RHOA, CTBP1, PPP2R5E, NFATC4, LRP6, CREBBP, SENP2, NFATC1, GSK3B, TCF7L1, CCND2, RAC2, LRP5, PLCB2, PRKCB, WNT10A, SMAD4, WNT5A, CHD8, NFATC2, RAC3, VANGL2, TBL1XR1, EP300",0.106793246940152,0.00656376950238827,FALSE
+"HCC44","Input","KEGG_ABC_TRANSPORTERS",0.27486,0.843,0.625,1943,0.789,"ABCC3, TAP2, ABCG1, ABCA1, ABCD4, ABCG2, ABCC4, ABCA3, TAP1",0.204119982655925,0.10292299679058,FALSE
+"HCC44","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.36325,-1.08,0.31,7099,0.661,"PIK3CA, RAF1, AKT2, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, BAD, SOS1, PIK3CD, EIF4EBP1, KIT, LEF1",0.508638306165727,0.17979854051436,FALSE
+"HCC44","Input","KEGG_ADHERENS_JUNCTION",-0.36307,-1.06,0.333,7376,0.624,"MAPK1, SSX2IP, TCF7L2, TCF7L1, MAPK3, ERBB2, CDH1, PTPN6, CTNNA2, CTNNA1, CTNND1, SRC, CTNNB1, WASF3, FARP2, RAC3, NECTIN4, FGFR1, PTPRF, NECTIN1, LEF1",0.47755576649368,0.204815410317576,FALSE
+"HCC44","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.36766,-1.09,0.31,7212,0.655,"PRKCQ, AKT2, CAMKK2, RXRA, PRKAA1, NFKBIE, PRKAG1, RXRG, CD36, ADIPOR1, ACSL1, ACSL6",0.508638306165727,0.183758700008217,FALSE
+"HCC44","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.59494,-1.68,0.0528,8712,0.42,"GLUL, ABAT, ALDH5A1, GLUD2",1.27736607746619,0.3767507096021,FALSE
+"HCC44","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.34789,-1.03,0.371,6325,0.595,"ATP1B1, PIK3R1, PIK3R2, IRS1, ATP1A4, INSR, ATP1A1, ATP1A3, PIK3CA, MAPK1, MAPK3, PDPK1, SCNN1A, PIK3CD, HSD11B2",0.430626090384954,0.22548303427145,FALSE
+"HCC44","Input","KEGG_ALZHEIMERS_DISEASE",-0.3673,-1.07,0.318,7130,0.641,"GNAQ, FAS, PPP3CC, COX5A, ATP5PF, PLCB3, CASP9, MAPK1, MAPK3, CDK5, APP, CASP8, MME, NCSTN, GRIN1, FADD, APH1A, CAPN1, BAD, ATP2A3, APOE, GSK3B, MAPT, CALM2, LPL, NDUFA4, CALML3, PPP3R1, PLCB4, APBB1, SNCA, BACE1",0.497572880015567,0.193141970481183,FALSE
+"HCC44","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.27894,0.869,0.598,2386,0.789,"RARS2, WARS2, FARS2, MARS2, MTFMT, LARS2",0.223298816011589,0.10292299679058,FALSE
+"HCC44","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.28436,0.865,0.57,2234,0.77,"GFPT2, GNPNAT1, GCK, GALE, UGDH, UXS1, PGM3, GMDS, HEXA, NANS",0.244125144327509,0.113509274827518,FALSE
+"HCC44","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.26042,0.793,0.686,272,0.823,"PRPH, PRPH2, NEFH, NEFM",0.163675884293248,0.0846001647877302,FALSE
+"HCC44","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.5863,1.81,0.0209,1943,0.549,"CD74, CTSS, RFXAP, TAPBP, B2M, RFX5, IFI30, CTSB, TAP2, PSME1, PSME2, PSME3, LGMN, HSPA5, CALR, TAP1",1.67985371388895,0.260427655549908,FALSE
+"HCC44","Input","KEGG_APOPTOSIS",-0.21172,-0.617,0.924,7099,0.976,"PIK3CA, IL1RAP, FAS, PPP3CC, AKT2, CASP9, CASP8, ENDOD1, FADD, CASP6, CAPN1, PRKAR2B, BAD, PIK3CD, BCL2, PPP3R1, TP53",0.0343280287798933,0.0105501823333082,FALSE
+"HCC44","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.63466,1.98,0.00554,99,0.545,"PTGES, PTGS2, PLA2G4A, GGT1",2.25649023527157,0.263603497723358,FALSE
+"HCC44","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.3632,-1.07,0.344,8510,0.641,"GATM, GLUL, CKMT1A, GLUD2",0.46344155742847,0.193141970481183,FALSE
+"HCC44","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.46641,-1.36,0.134,8197,0.554,"CTNNA2, CTNNA1, DAG1, SGCB, ITGB6, CTNNB1, PKP2, ITGA6, ITGA11, SGCG, DSC2, CACNA2D1, ITGA4, LEF1, CDH2, ITGB8",0.872895201635192,0.25649023527157,FALSE
+"HCC44","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.56049,1.74,0.0537,2844,0.401,"ALDH2, ALDH1B1, UGDH, ALDH3A2, ALDH7A1",1.27002571430044,0.396855627379818,FALSE
+"HCC44","Input","KEGG_AXON_GUIDANCE",-0.44133,-1.28,0.178,7185,0.617,"EPHA5, LIMK2, PPP3CC, EFNA5, EPHB1, PAK4, SEMA4C, DPYSL2, MAPK1, NTN4, ARHGEF12, MAPK3, CDK5, L1CAM, EPHA1, DPYSL5, EPHA7, EPHB4, EFNB1, EFNA1, SEMA3C, PLXNA3, PLXNA2, ROBO1, NCK2, PAK5, PAK6, GSK3B, RAC3, EPHB3, PLXNB3, PPP3R1, SEMA4D, EPHA4, EPHA3, SEMA6D, SEMA5A",0.749579997691106,0.209714835966758,FALSE
+"HCC44","Input","KEGG_BASAL_CELL_CARCINOMA",-0.46082,-1.37,0.131,6849,0.559,"APC, WNT5A, FZD1, SUFU, WNT11, TCF7L2, TCF7L1, FZD6, CTNNB1, GSK3B, TP53, LEF1",0.882728704344236,0.252588192113577,FALSE
+"HCC44","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.60458,1.88,0.0169,2061,0.552,"TAF12, GTF2F1, GTF2F2, GTF2E2, GTF2H2, TAF11, GTF2A2, GTF2E1, TBP, GTF2H1, GTF2H3, TAF9, TAF10, GTF2H4, GTF2B",1.77211329538633,0.258060922270801,FALSE
+"HCC44","Input","KEGG_BASE_EXCISION_REPAIR",0.16293,0.492,0.998,1419,1,"PARP2, HMGB1, MBD4, NTHL1",0.000869458712628891,0,FALSE
+"HCC44","Input","KEGG_BETA_ALANINE_METABOLISM",0.23723,0.716,0.81,1312,0.909,"ALDH2, EHHADH, MLYCD, ALDH1B1",0.0915149811213502,0.0414361167780325,FALSE
+"HCC44","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.31543,0.945,0.473,1391,0.749,"ELOVL5, ACOT2, ACOT1, HACD2, YOD1, ACOT7",0.325138859262188,0.125518182300534,FALSE
+"HCC44","Input","KEGG_BLADDER_CANCER",0.3647,1.13,0.263,170,0.658,"MYC, MMP1, CDKN2A, VEGFA",0.580044251510242,0.181774106386044,FALSE
+"HCC44","Input","KEGG_BUTANOATE_METABOLISM",-0.36396,-1.07,0.339,8659,0.641,"ACADS, ABAT, ALDH5A1, HMGCS1",0.469800301796918,0.193141970481183,FALSE
+"HCC44","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.38816,-1.12,0.282,7081,0.651,"NFATC2, PIK3CA, RAF1, PPP3CC, AKT2, MAPK1, VAV2, MAPK3, BTK, NFKBIE, GRB2, PTPN6, SOS1, VAV3, GSK3B, PIK3CD, SYK, PIK3AP1, CD81, RAC3, PLCG2, PPP3R1",0.549750891680639,0.186419011431808,FALSE
+"HCC44","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.33855,-1,0.425,6461,0.641,"ATP2B2, ATP2B4, VDAC3, TACR1, ATP2A1, PHKA2, PLCB1, SLC25A4, NOS1, SLC8A1, PLCB2, GNAQ, P2RX7, PPP3CC, CAMK2B, ADCY9, PLCB3, ITPKB, GNA11, CAMK2D, ERBB2, GRIN1, PLCG1, PLCD1, ATP2A3, CALM2, ERBB3, PLCG2, CALML3, PPP3R1, PLCB4",0.371611069949688,0.193141970481183,FALSE
+"HCC44","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.38684,-1.14,0.273,6095,0.657,"COX6B1, CYC1, CACNA1F, ATP1B1, UQCRFS1, COX5B, ATP1A4, TPM4, UQCRQ, MYH7, SLC8A1, ATP1A1, ATP1A3, COX5A, TPM1, TPM3, SLC9A1, CACNA2D1",0.563837352959244,0.182434630440219,FALSE
+"HCC44","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.56324,-1.65,0.0505,8461,0.43,"PTPRC, CD99, NRCAM, SDC1, CDH15, CDH3, CD276, ITGA6, VCAN, SDC4, ITGA4, PTPRF, NCAM1, NECTIN1, CADM1, SDC2, CDH4, CDH2, ITGB8, JAM3, CNTNAP2",1.29670862188134,0.366531544420413,FALSE
+"HCC44","Input","KEGG_CELL_CYCLE",-0.24385,-0.712,0.823,6921,0.93,"CDC25C, WEE1, CDC45, CDKN1A, CREBBP, CDK2, BUB1B, PLK1, PTTG1, SKP1, YWHAB, CCND1, ANAPC4, CCNB3, CCNA2, CCNB2, TTK, YWHAZ, FZR1, CDC20, BUB1, CHEK1, CCNB1, GSK3B, CDK1, RB1, PKMYT1, TP53",0.0846001647877302,0.0315170514460649,FALSE
+"HCC44","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.28983,-0.859,0.626,7044,0.797,"PLCB2, GNG4, PIK3CA, RAF1, AKT2, ADCY9, PLCB3, MAPK1, TIAM2, CCL13, VAV2, MAPK3, GRK2, ARRB2, ARRB1, GRB2, PRKCD, STAT1, CCL14, STAT2, GSK3A, SOS1, VAV3, GRK5, CSK, GSK3B, PIK3CD, PREX1, GRK6, PRKCZ, PLCB4",0.20342566678957,0.0985416786038876,FALSE
+"HCC44","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.28494,0.881,0.59,268,0.777,"MYC, TGFB1, CDKN2A, TGFB2, MECOM",0.229147988357856,0.109578981199086,FALSE
+"HCC44","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.2745,0.837,0.588,1541,0.788,"SDHA, ACLY, PCK2, SDHD, SDHC, DLST",0.230622673923862,0.103473782510445,FALSE
+"HCC44","Input","KEGG_COLORECTAL_CANCER",0.30816,0.93,0.511,181,0.765,"RAC2, MYC, JUN, TGFB1, TGFB2",0.291579099865287,0.116338564846382,FALSE
+"HCC44","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.37428,1.16,0.278,399,0.66,"CFB, THBD, PLAUR, SERPINE1, C3, MBL2, PLAU, F8",0.555955204081924,0.180456064458131,FALSE
+"HCC44","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.37767,1.14,0.259,2642,0.658,"CTH, BHMT, CBS, AHCYL1, MAT2B, GOT2, MPST, AHCYL2, MAT1A, SDS, MAT2A, MTAP",0.586700235918748,0.181774106386044,FALSE
+"HCC44","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.33436,1.03,0.381,546,0.65,"CXCL5, CD40, TGFB1, TNFRSF10B, VEGFA, TGFB2, BMPR2, EPO, CSF1",0.419075024324381,0.187086643357144,FALSE
+"HCC44","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",0.26539,0.821,0.628,1093,0.806,"NFKB1, IRF3, PYCARD, POLR3G, CASP1",0.202040356262804,0.0936649581949093,FALSE
+"HCC44","Input","KEGG_DILATED_CARDIOMYOPATHY",0.29172,0.902,0.525,846,0.764,"DES, TGFB1, TGFB2, ITGA1, ITGA2, LAMA2, ITGA3, ITGB3, ITGB1, GNAS, ITGA5",0.279840696594043,0.11690664142431,FALSE
+"HCC44","Input","KEGG_DNA_REPLICATION",0.23591,0.701,0.827,4125,0.92,"RNASEH2A, SSBP1, RNASEH2B, RFC1, RFC3, RPA1, MCM3, POLD3, MCM6, MCM2, MCM5, RPA2, POLD1, RFC4, RFC2, MCM7, POLD2, MCM4, RPA3, POLE3, RNASEH1, RFC5",0.0824944904474534,0.0362121726544447,FALSE
+"HCC44","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.43405,-1.27,0.187,7376,0.614,"MAPK1, MAPK3, GRB2, SOS1, NOTCH3",0.728158393463501,0.211831628858832,FALSE
+"HCC44","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.54485,-1.6,0.0457,7126,0.407,"GSTM3, GSTT2, ALDH3A1, MAOB, MAOA, MGST2, ADH4, ADH7, MGST3, GSTM1, ADH5, GSTP1, GSTM4",1.34008379993015,0.39040559077478,FALSE
+"HCC44","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",0.45365,1.38,0.116,1597,0.435,"CDA, UPP1, TYMP, NAT2, GMPS, HPRT1, GUSB, NAT1, TPMT",0.935542010773082,0.361510743045363,FALSE
+"HCC44","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.38056,-1.13,0.292,7550,0.647,"SPP1, LAMA3, LAMA4, HMMR, ITGB4, TNXB, CD36, COL1A2, DAG1, VTN, ITGB6, SDC1, ITGA6, FN1, COL1A1, ITGA11, COL3A1, SDC4, ITGA4, SDC2, THBS1, SV2B, ITGB8",0.534617148551582,0.1890957193313,FALSE
+"HCC44","Input","KEGG_ENDOCYTOSIS",-0.29762,-0.889,0.544,6737,0.762,"CHMP5, HSPA1A, EPS15, TSG101, VPS4B, EHD2, CHMP2A, CHMP2B, ARFGAP2, VPS37C, VPS4A, VPS37A, RNF41, STAM2, RAB11FIP1, GRK2, ARRB2, ARRB1, DAB2, IQSEC2, RAB5B, SMAP1, GIT1, SH3GLB2, ASAP1, RAB11A, SMURF2, HSPA2, AGAP1, RAB4A, PARD6G, SRC, HSPA1L, GRK5, EPN3, ASAP3, ERBB3, GRK6, KIT, PRKCZ, SH3GL2, MVB12B",0.26440110030182,0.1180450286604,FALSE
+"HCC44","Input","KEGG_ENDOMETRIAL_CANCER",-0.48139,-1.44,0.0811,7099,0.595,"PIK3CA, RAF1, AKT2, CASP9, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, ERBB2, CDH1, BAD, CTNNA2, SOS1, CTNNA1, PDPK1, CTNNB1, GSK3B, PIK3CD, TP53, LEF1",1.09097914578884,0.22548303427145,FALSE
+"HCC44","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.40431,-1.19,0.242,5983,0.678,"RELA, ATP6AP1, PTPN11, ATP6V0A2, LYN, MAPK10, ADAM17, IKBKB, ATP6V0D1, CASP3, ATP6V1B2, ATP6V1A, ATP6V1E1, MAPK14, ATP6V1B1, ATP6V0A1, ADAM10, ATP6V1C2, MAPK13, ATP6V1H, ATP6V1F, MAPK12, GIT1, ATP6V1C1, ATP6V1D, F11R, PLCG1, PTPRZ1, SRC, CSK, PLCG2, JAM3",0.616184634019569,0.168770306132937,FALSE
+"HCC44","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.33069,-0.97,0.43,7099,0.666,"PIK3CA, RAF1, CDKN1A, CAMK2B, AKT2, PAK4, MAPK1, MAPK3, CAMK2D, GRB2, ERBB2, BAD, PLCG1, SOS1, SRC, NCK2, PAK5, PAK6, GSK3B, PIK3CD, AREG, ERBB3, EIF4EBP1, PLCG2",0.366531544420413,0.176525770829699,FALSE
+"HCC44","Input","KEGG_ETHER_LIPID_METABOLISM",0.44664,1.42,0.0982,1947,0.4,"PLA2G4A, PLPP3, LPCAT1, PLD1, PLA2G12A, CHPT1, PLPP2",1.00788851221305,0.397940008672038,FALSE
+"HCC44","Input","KEGG_FATTY_ACID_METABOLISM",-0.36034,-1.06,0.357,8430,0.624,"ADH4, ADH7, ACADS, ACSL1, ADH5, ACSL6",0.447331783887807,0.204815410317576,FALSE
+"HCC44","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.35271,-1.04,0.41,6863,0.608,"MAPK14, GAB2, PIK3CA, RAF1, AKT2, MAPK13, MAPK1, VAV2, MAPK3, BTK, MAPK12, GRB2, PRKCD, PLCG1, SOS1, MAP2K6, VAV3, PDPK1, PIK3CD, SYK, RAC3, PLCG2",0.387216143280265,0.216096420727265,FALSE
+"HCC44","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.27993,-0.824,0.661,7099,0.835,"PIK3CA, RAF1, LIMK2, AKT2, MAPK1, PLPP1, VAV2, MAPK3, MYO10, ARPC1A, ASAP1, PRKCD, PLCG1, VAV3, PTPRC, SCIN, WASF3, MARCKSL1, PIK3CD, SYK, ASAP3, GSN, PLCG2",0.17979854051436,0.0783135245163979,FALSE
+"HCC44","Input","KEGG_FOCAL_ADHESION",0.27716,0.863,0.632,986,0.762,"RAC2, FLNC, JUN, LAMC2, VEGFA, COL4A1, ZYX, ITGA1, LAMB3, LAMB1, ITGA2, CAV2, FLNB, ACTN1, COL4A2, LAMA2, ACTN4, ITGA3, ITGB3, COL6A1, FLNA, BIRC2, ACTN2, ITGB1, ITGA5, VCL, MYLK, MYL12A, MYL9, COL6A2",0.199282921717615,0.1180450286604,FALSE
+"HCC44","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.64236,-1.88,0.0141,8355,0.311,"DHFR, GCH1, ALPI, ALPP",1.85078088734462,0.507239610973163,FALSE
+"HCC44","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.53878,-1.57,0.065,6785,0.399,"PFKL, ALDOA, AKR1B10, MTMR6, HK1, PFKFB2, MPI, PFKFB4, ALDOC, FBP1, ALDOB, KHK",1.18708664335714,0.399027104313252,FALSE
+"HCC44","Input","KEGG_GALACTOSE_METABOLISM",-0.2428,-0.711,0.844,7781,0.921,"HK1, GAA, GALT",0.073657553374345,0.0357403698031511,FALSE
+"HCC44","Input","KEGG_GAP_JUNCTION",-0.26558,-0.77,0.729,7044,0.862,"PLCB2, GNAQ, RAF1, CSNK1D, ADCY9, PLCB3, MAPK1, MAPK3, GNA11, GRB2, SOS1, SRC, CDK1, PLCB4",0.137272471682025,0.0644927341752872,FALSE
+"HCC44","Input","KEGG_GLIOMA",-0.42945,-1.23,0.217,7099,0.634,"PIK3CA, RAF1, CDKN1A, CAMK2B, AKT2, MAPK1, MAPK3, CCND1, CAMK2D, GRB2, PLCG1, SOS1, PIK3CD, CALM2, RB1, PLCG2, CALML3, TP53",0.66354026615147,0.197910742118267,FALSE
+"HCC44","Input","KEGG_GLUTATHIONE_METABOLISM",-0.37557,-1.09,0.301,7126,0.655,"GSTM3, GSTT2, IDH2, RRM2, PGD, IDH1, GPX2, MGST2, MGST3, OPLAH, GSTM1, RRM2B, GSTP1, GSTM4",0.521433504406157,0.183758700008217,FALSE
+"HCC44","Input","KEGG_GLYCEROLIPID_METABOLISM",0.24485,0.747,0.78,1947,0.87,"PLPP3, GPAT3, ALDH2, GK, DGKE, ALDH1B1, AGK, AGPAT1, PLPP2",0.10790539730952,0.0604807473813815,FALSE
+"HCC44","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",0.3003,0.909,0.526,2217,0.763,"PLA2G4A, PLPP3, GPAT3, LPCAT1, MBOAT7, PLD1, PTDSS2, DGKE, PLA2G12A, CDS1, CHPT1, AGPAT1, PLPP2, PTDSS1, AGPAT2",0.279014255846261,0.11747546204512,FALSE
+"HCC44","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.33536,-0.989,0.432,7499,0.651,"MAOB, GAMT, PHGDH, MAOA, GLDC, GATM, SARDH",0.364516253185088,0.186419011431808,FALSE
+"HCC44","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.44793,-1.31,0.151,8430,0.603,"ADH4, ADH7, ALDOC, ACSS2, FBP1, ALDOB, ADH5, ACSS1, PGAM2",0.821023052706831,0.219682687859849,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.44936,1.37,0.154,2434,0.412,"DSE, CHST12, CHST7, B3GALT6, CHPF, CHSY3",0.812479279163537,0.385102783966865,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.35868,-1.04,0.363,5526,0.608,"EXTL2, B3GAT3, GLCE, NDST1, HS2ST1, EXTL3, EXT2",0.440093374963888,0.216096420727265,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.51964,1.61,0.0678,826,0.345,"ST3GAL2, B4GALT1, FUT8",1.16877030613294,0.462180904926726,FALSE
+"HCC44","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.32816,1.03,0.385,1110,0.65,"IDS, IDUA, GUSB, NAGLU",0.414539270491499,0.187086643357144,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.37161,1.15,0.257,2769,0.66,"ST3GAL2, SLC33A1, HEXA, GLB1",0.590066876668705,0.180456064458131,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",0.38117,1.2,0.204,2169,0.625,"ST3GAL2, B3GALNT1, HEXA",0.690369832574101,0.204119982655925,FALSE
+"HCC44","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",0.38501,1.19,0.233,820,0.622,"FUT4, B4GALT1",0.632644078973981,0.206209615309181,FALSE
+"HCC44","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.24229,-0.708,0.822,5223,0.915,"PIGG, PIGS, PIGK, PIGH, PIGO, PIGT, GPAA1, PIGU, PIGQ, PGAP1",0.0851281824599496,0.0385789059335517,FALSE
+"HCC44","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.34536,1.08,0.312,2243,0.631,"MTHFD2, MTHFD1L, MTHFD1",0.505845405981557,0.199970640755866,FALSE
+"HCC44","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.29929,-0.887,0.575,6782,0.755,"PLCB1, MAP3K3, MAPK14, PLCB2, GNAQ, RAF1, CAMK2B, MAPK13, ADCY9, PLCB3, MAPK1, MAP3K4, MAPK3, GNA11, MAPK12, CAMK2D, GRB2, PRKCD, SOS1, MAP2K6, SRC, CGA, CALM2, CALML3, PLCB4",0.24033215531037,0.122053048370812,FALSE
+"HCC44","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.35594,-1.04,0.365,6848,0.608,"CSNK1G3, WNT5A, BTRC, CSNK1E, SUFU, CSNK1D, WNT11, CSNK1G1, CSNK1A1, BMP6, GSK3B",0.437707135543525,0.216096420727265,FALSE
+"HCC44","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.52514,1.66,0.0491,846,0.337,"ANPEP, CD37, ITGA1, CD44, ITGA2, EPO, CSF1, CD38, ITGA3, ITGB3, CD55, ITGA5",1.30891850787703,0.472370099128661,FALSE
+"HCC44","Input","KEGG_HISTIDINE_METABOLISM",0.33112,1.02,0.371,677,0.641,"ALDH1A3, ALDH2, ALDH3B1",0.430626090384954,0.193141970481183,FALSE
+"HCC44","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.26237,0.805,0.696,3877,0.825,"SSBP1, RAD50, NBN, TOP3B, RPA1, EME1, POLD3, MRE11, RPA2, POLD1, POLD2, RPA3",0.157390760389438,0.0835460514500749,FALSE
+"HCC44","Input","KEGG_HUNTINGTONS_DISEASE",0.17395,0.552,0.987,3114,1,"SOD2, TGM2, SDHA, POLR2I, ATP5MC2, NDUFA10, NDUFA7, SDHD, POLR2K, SDHC, NDUFC1, NDUFV3, TBP, AP2A1, UQCRH, RCOR1, NDUFS6, NDUFS5, AP2B1, NDUFB7, AP2S1, PPID, DNAL1, TFAM, NDUFS3, NDUFA3, NDUFA5, NDUFV1, CYCS, ITPR1, HAP1, GPX1, AP2A2, NDUFB4, NDUFS8, VDAC1, IFT57, HDAC2, NDUFA2, NDUFB9, NDUFA8, BAX, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1, AP2M1, DLG4, DCTN1",0.00568284733036327,0,FALSE
+"HCC44","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.33486,-0.971,0.457,7785,0.674,"TPM1, PRKAG1, ITGB4, TPM3, IL6, DAG1, SGCB, ACE, ITGB6, ITGA6, ITGA11, SGCG, CACNA2D1, ITGA4, ITGB8",0.34008379993015,0.17134010346468,FALSE
+"HCC44","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.43038,-1.26,0.183,6671,0.613,"PI4KA, PLCB1, PIP4K2C, PLCB2, PIK3CA, INPP1, PI4KB, PLCB3, ITPKB, IMPA2, INPPL1, PLCG1, ISYNA1, PLCD1, INPP5A, PIK3CD, PLCG2, PLCB4",0.737548910269571,0.212539525481585,FALSE
+"HCC44","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.31983,-0.94,0.493,6396,0.703,"SHC1, ELK1, PIK3R1, PYGB, PIK3R2, IRS1, GYS1, RAPGEF1, EIF4E2, PHKA2, INSR, PTPN1, PIK3CA, TSC2, FASN, RAF1, AKT2, MAPK1, PRKAA1, MAPK3, GRB2, HK1, PRKAG1, PRKAR2B, BAD, SOS1, PDPK1, GSK3B, PIK3CD, CALM2, PTPRF, EIF4EBP1, PDE3A, FBP1, CALML3, PRKCZ",0.30715308072277,0.153044674980176,FALSE
+"HCC44","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.52442,1.62,0.0392,102,0.36,"CD40, TGFB1",1.40671393297954,0.443697499232713,FALSE
+"HCC44","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.30632,-0.901,0.556,6961,0.749,"IL10RB, TYK2, PIK3CA, AKT2, CREBBP, STAM2, CCND1, IFNGR1, IL13RA1, GRB2, OSM, PTPN6, STAT1, STAT2, PIAS1, IL6, SOS1, LIFR, IFNAR1, IL13RA2, IL6ST, PIK3CD",0.254925208417942,0.125518182300534,FALSE
+"HCC44","Input","KEGG_LEISHMANIA_INFECTION",0.55087,1.69,0.0438,281,0.372,"ITGB2, PTGS2, JUN, TGFB1, CYBA, TGFB2, C3, NCF2",1.3585258894959,0.429457060118102,FALSE
+"HCC44","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",0.32492,1.02,0.417,961,0.641,"RAC2, ITGB2, ICAM1, CYBA, CLDN11, NCF2, MSN, ACTN1, ACTN4, ACTN2, ITGB1, VCL, MYL12A, MYL9",0.379863945026242,0.193141970481183,FALSE
+"HCC44","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.53891,1.68,0.0473,1312,0.346,"ALDH2, EHHADH, YOD1, ALDH1B1",1.32513885926219,0.460923901207223,FALSE
+"HCC44","Input","KEGG_LONG_TERM_DEPRESSION",-0.26772,-0.806,0.723,6096,0.838,"LYN, GNAI3, ARAF, GNAI1, PPP2CA, PLCB1, NOS1, GNA13, PLCB2, GNAQ, RAF1, PLCB3, MAPK1, MAPK3, GNA11, GNA12, GNAO1, PLCB4",0.140861702705469,0.0767559813697235,FALSE
+"HCC44","Input","KEGG_LONG_TERM_POTENTIATION",-0.36226,-1.05,0.367,6646,0.621,"RPS6KA1, EP300, PLCB1, RPS6KA6, PLCB2, GNAQ, RAF1, PPP3CC, CAMK2B, CREBBP, PLCB3, MAPK1, MAPK3, CAMK2D, GRIN1, CALM2, CALML3, PPP3R1, PLCB4",0.435333935747911,0.20690839982342,FALSE
+"HCC44","Input","KEGG_LYSINE_DEGRADATION",0.24475,0.755,0.794,1718,0.868,"PLOD2, ALDH2, AASS, SETD7, EHHADH, ALDH1B1, PLOD1, PLOD3, DLST, GCDH",0.100179497572904,0.0614802748235081,FALSE
+"HCC44","Input","KEGG_LYSOSOME",-0.20812,-0.604,0.953,6740,0.977,"GLA, SMPD1, ACP5, ATP6V0A1, PSAP, AP3M2, CLN3, NPC2, HGSNAT, ATP6V1H, CTSA, AP1S2, SLC11A2, NAGA, CD63, SORT1, AP4E1, SCARB2, LIPA, ASAH1, LAPTM4B, AP1M2, ABCA2, NEU1, CTSF, GAA, GM2A, AP3B2, CTSH, GALC",0.0209070993616736,0.0101054362812269,FALSE
+"HCC44","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.3273,1.01,0.413,502,0.645,"RAC2, MYC, FLNC, JUN, ATF4, PLA2G4A, TGFB1, TGFB2, NFKB2, RELB, MECOM, MKNK1, FLNB, MOS, FGF13, FGF2, ELK4, DDIT3",0.384049948343599,0.190440285364732,FALSE
+"HCC44","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",0.72348,2.21,0.00258,1780,0.299,"IAPP, GCK, HES1, FOXA2",2.58838029403677,0.52432881167557,FALSE
+"HCC44","Input","KEGG_MELANOGENESIS",-0.55602,-1.63,0.0518,6694,0.393,"EP300, PLCB1, WNT5A, FZD1, PLCB2, GNAQ, RAF1, CAMK2B, CREBBP, WNT11, ADCY9, PLCB3, MAPK1, TCF7L2, TCF7L1, MAPK3, CAMK2D, FZD6, CTNNB1, GSK3B, CALM2, GNAO1, KIT, CALML3, PLCB4, LEF1",1.28567024025477,0.405607449624573,FALSE
+"HCC44","Input","KEGG_MELANOMA",-0.34994,-1.03,0.387,7099,0.595,"PIK3CA, RAF1, CDKN1A, AKT2, MAPK1, MAPK3, CCND1, CDH1, BAD, HGF, PIK3CD, RB1, FGFR1, TP53",0.412289034981089,0.22548303427145,FALSE
+"HCC44","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.58979,-1.74,0.0393,7957,0.475,"AKR1C2, AKR1C3, AKR1C1, EPHX1, MGST2, ADH4, ADH7, MGST3, CYP1A1, GSTM1, ADH5, GSTP1, GSTM4",1.40560744962457,0.323306390375133,FALSE
+"HCC44","Input","KEGG_MISMATCH_REPAIR",0.36698,1.12,0.278,3877,0.621,"SSBP1, MLH1, MSH3, RFC1, RFC3, PMS2, RPA1, POLD3, MSH2, RPA2, POLD1, RFC4, RFC2, POLD2, RPA3",0.555955204081924,0.20690839982342,FALSE
+"HCC44","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.39091,-1.15,0.267,5532,0.67,"AKT1, RPS6KA3, RPS6KB2, RPS6KA2, BRAF, RPS6KB1, PIK3CB, RICTOR, STRADA, PIK3R1, PIK3R2, RPS6KA1, CAB39, EIF4E2, RPS6KA6, PIK3CA, TSC2, AKT2, ULK1, MAPK1, PRKAA1, MAPK3, CAB39L, PDPK1, PIK3CD, EIF4EBP1",0.573488738635425,0.173925197299174,FALSE
+"HCC44","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",0.29373,0.918,0.517,140,0.774,"RAC2, ITGB2, ICAM1, TNFRSF10B",0.286509456906058,0.111259039317107,FALSE
+"HCC44","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.28383,-0.837,0.646,7533,0.82,"CHRNE, GRIN1, PLG, F2, CGA, HCRTR1",0.189767482004916,0.0861861476162833,FALSE
+"HCC44","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.3974,-1.17,0.258,6584,0.682,"PIK3R2, IRS1, RAPGEF1, RPS6KA1, GAB1, MAP3K3, MAPK14, RPS6KA6, SH2B1, PIK3CA, RAF1, CAMK2B, AKT2, MAPK13, MAPK1, YWHAB, MAPK3, MAPK12, NFKBIE, CAMK2D, GRB2, YWHAZ, SORT1, PRKCD, BAD, PLCG1, SOS1, MAPKAPK2, PDPK1, FRS2, CSK, GSK3B, PIK3CD, CALM2, BCL2, MAGED1, PLCG2, ARHGDIB, CALML3, TP53, TP73, NGFR",0.58838029403677,0.166215625343521,FALSE
+"HCC44","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.38997,1.21,0.207,806,0.628,"NAMPT, NT5E, NNMT, PNP, CD38, ENPP1",0.684029654543082,0.202040356262804,FALSE
+"HCC44","Input","KEGG_NITROGEN_METABOLISM",-0.68798,-2.03,0.00812,8712,0.177,"GLUL, CA3, GLUD2",2.09044397075882,0.752026733638193,TRUE
+"HCC44","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.19739,-0.579,0.966,7323,0.984,"MAPK13, MAPK1, CCL13, MAPK3, MAPK12, CASP8, IL6, CARD8, TAB3",0.0150228735845067,0.00700490156865849,FALSE
+"HCC44","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.33699,1.04,0.352,3676,0.694,"XRCC4, XRCC5, RAD50, LIG4, MRE11, XRCC6, DCLRE1C, PRKDC",0.453457336521869,0.158640529545145,FALSE
+"HCC44","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.3733,-1.1,0.3,7099,0.663,"PIK3CA, RAF1, AKT2, CASP9, MAPK1, RXRA, MAPK3, CCND1, GRB2, ERBB2, RXRG, BAD, PLCG1, SOS1, PDPK1, PIK3CD, RB1, PLCG2, TP53",0.522878745280338,0.178486471595227,FALSE
+"HCC44","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.54645,-1.63,0.0447,7246,0.393,"CREBBP, LFNG, MAML2, NCSTN, DLL1, APH1A, DLL3, JAG1, DTX3L, NOTCH3, DLL4",1.34969247686806,0.405607449624573,FALSE
+"HCC44","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.1578,0.48,0.992,7687,0.997,"ERCC2, GTF2H2, CCNH, GTF2H1, GTF2H3, GTF2H4, MNAT1, RFC1, RFC3, RPA1, POLD3, XPA, ERCC5, RPA2, POLD1, RFC4, RFC2, POLD2, RAD23A, RPA3, CDK7, POLE3, RFC5, POLD4, POLE4, ERCC4, CUL4A, ERCC3, LIG1, PCNA, CUL4B, DDB2, RAD23B, GTF2H5, DDB1, XPC, POLE, ERCC6, CETN2",0.00348832784582135,0.00130484168834428,FALSE
+"HCC44","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.40193,-1.16,0.266,9117,0.684,"MAN1C1",0.575118363368933,0.164943898279884,FALSE
+"HCC44","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.57695,-1.7,0.0373,7230,0.435,"CAMK2B, ARRB2, CAMK2D, CLCA2, CALM2, CALML3",1.42829116819131,0.361510743045363,FALSE
+"HCC44","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.36623,1.12,0.28,2243,0.621,"MTHFD2, MTHFR, SHMT2, MTHFD1L, GART, MTFMT, MTHFD1",0.552841968657781,0.20690839982342,FALSE
+"HCC44","Input","KEGG_OOCYTE_MEIOSIS",-0.44054,-1.29,0.164,6898,0.619,"PPP2R5A, CDC25C, RPS6KA6, BTRC, PPP2R5D, PPP2R5B, PPP3CC, CAMK2B, ADCY9, CDK2, MAPK1, AURKA, PLK1, PTTG1, SKP1, YWHAB, MAPK3, ANAPC4, CCNB2, MAPK12, SGO1, CAMK2D, YWHAZ, CDC20, BUB1, CCNB1, CDK1, FBXO5, CALM2, PKMYT1, CALML3, PPP3R1",0.785156151952302,0.208309350979882,FALSE
+"HCC44","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.46926,1.48,0.0896,2769,0.434,"FUCA1, FUCA2, MAN2B2, MAN2B1, MANBA, HEXA, ENGASE, GLB1",1.04769199033787,0.362510270487489,FALSE
+"HCC44","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.17295,0.531,0.985,3054,1,"COX11, SDHA, ATP5MC2, COX17, TCIRG1, NDUFA10, NDUFA7, SDHD, SDHC, NDUFC1, NDUFV3, UQCRH, NDUFS6, NDUFS5, NDUFB7, NDUFA11, NDUFS3, NDUFA3, NDUFA5, ATP5ME, NDUFV1, NDUFB4, NDUFS8, NDUFA2, NDUFB9, NDUFA8, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1",0.00656376950238827,0,FALSE
+"HCC44","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.55789,1.78,0.0205,1574,0.41,"GALNT14, GALNT11, GALNT6, ST3GAL2, C1GALT1, GALNT15, C1GALT1C1, GALNT16, GALNT17",1.68824613894425,0.387216143280265,FALSE
+"HCC44","Input","KEGG_P53_SIGNALING_PATHWAY",-0.39537,-1.15,0.274,7115,0.67,"TSC2, FAS, CDKN1A, CDK2, CASP9, RRM2, CCND1, CCNB3, COP1, CCNB2, CASP8, CHEK1, CCNB1, IGFBP3, CDK1, THBS1, RRM2B, TP53, TP73",0.562249437179612,0.173925197299174,FALSE
+"HCC44","Input","KEGG_PANCREATIC_CANCER",0.33514,1.03,0.377,181,0.65,"RAC2, TGFB1, CDKN2A, TGFA, VEGFA, TGFB2",0.423658649794207,0.187086643357144,FALSE
+"HCC44","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.32182,-0.945,0.497,6600,0.704,"PPCDC, BCAT2, PANK2, DPYD, PPCS",0.303643611266668,0.152427340857888,FALSE
+"HCC44","Input","KEGG_PARKINSONS_DISEASE",0.20479,0.634,0.929,3177,0.98,"UCHL1, SDHA, UBE2J2, ATP5MC2, NDUFA10, NDUFA7, SDHD, SDHC, NDUFC1, NDUFV3, UQCRH, NDUFS6, NDUFS5, NDUFB7, SLC18A1, PPID, NDUFS3, NDUFA3, NDUFA5, NDUFV1, CYCS, NDUFB4, NDUFS8, PARK7, VDAC1, NDUFA2, NDUFB9, NDUFA8, NDUFS2, SDHB, NDUFS4, COX7A2L, NDUFB1, HTRA2, NDUFC2",0.0319842860063582,0.00877392430750515,FALSE
+"HCC44","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.17262,-0.501,0.993,7725,1,"YWHAZ, CDH1, ARPC1A, NCK2, CTNNB1",0.00305075150461883,0,FALSE
+"HCC44","Input","KEGG_PATHWAYS_IN_CANCER",0.29139,0.891,0.53,654,0.771,"RAC2, PTGS2, TRAF1, SMO, MYC, MMP1, JUN, TGFB1, CDKN2A, TGFA, LAMC2, VEGFA, TGFB2, COL4A1, NFKB2, MECOM, LAMB3, LAMB1, ITGA2, COL4A2, FGF13, FGF2, LAMA2, ITGA3, NFKB1",0.275724130399211,0.112945621949043,FALSE
+"HCC44","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.27016,-0.804,0.694,6692,0.831,"XYLB, RPE, CRYL1, DCXR",0.158640529545145,0.080398976215889,FALSE
+"HCC44","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.2787,-0.818,0.64,8757,0.836,"ALDOC, FBP1, ALDOB",0.193820026016113,0.0777937225609836,FALSE
+"HCC44","Input","KEGG_PEROXISOME",-0.35755,-1.05,0.356,7202,0.621,"PEX11A, PECR, IDH2, NUDT12, PRDX5, SLC27A2, ACOX1, IDH1, PMVK, PXMP4, CROT, PHYH, EPHX2, AMACR, ACSL1, MVK, FAR1, ACSL6",0.448550002027125,0.20690839982342,FALSE
+"HCC44","Input","KEGG_PHENYLALANINE_METABOLISM",-0.3629,-1.06,0.36,7308,0.624,"ALDH3A1, PRDX6, MAOB, MAOA, TAT, DDC",0.443697499232713,0.204815410317576,FALSE
+"HCC44","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.35587,-1.03,0.38,6489,0.595,"PIK3R1, PIK3R2, PI4KA, PLCB1, PIP4K2C, DGKZ, PLCB2, PIK3CA, INPP1, PI4KB, PLCB3, DGKD, ITPKB, IMPA2, INPPL1, PLCG1, PLCD1, INPP5A, PIK3CD, CALM2, PLCG2, CALML3, PLCB4",0.42021640338319,0.22548303427145,FALSE
+"HCC44","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.26804,-0.789,0.701,7116,0.848,"BLVRA, COX15, HMOX1, ALAD, BLVRB, FTH1",0.154281982033341,0.0716041477432862,FALSE
+"HCC44","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.42759,-1.24,0.182,7011,0.633,"SLC27A1, UBC, OLR1, RXRA, ANGPTL4, SLC27A2, FABP3, ACOX1, FADS2, RXRG, CD36, FABP4, PDPK1, CYP27A1, SCD, SCD5, FABP7, LPL, APOC3, ACSL1, ACSL6",0.739928612014925,0.198596289982645,FALSE
+"HCC44","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.48641,1.52,0.0767,871,0.404,"CD40, RFXAP, RFX5, TAP2",1.11520463605102,0.393618634889395,FALSE
+"HCC44","Input","KEGG_PRION_DISEASES",-0.31073,-0.905,0.548,6344,0.751,"NOTCH1, ELK1, STIP1, HSPA1A, MAPK1, LAMC1, MAPK3, C9, IL6, NCAM1",0.261219441515631,0.124360062995832,FALSE
+"HCC44","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.46332,-1.37,0.138,5532,0.559,"AKT1, RPS6KA3, MAPK9, HSP90AA1, RPS6KA2, BRAF, GNAI2, KRAS, PIK3CB, MAD2L1, ANAPC7, MAPK10, GNAI3, ARAF, ADCY5, GNAI1, PIK3R1, PIK3R2, RPS6KA1, MAPK14, CDC25C, RPS6KA6, PIK3CA, RAF1, AKT2, MAPK13, ADCY9, CDK2, MAPK1, PLK1, MAPK3, ANAPC4, CCNB3, CCNA2, CCNB2, MAPK12, FZR1, BUB1, CCNB1, PIK3CD, CDK1, PDE3A, PKMYT1",0.860120913598763,0.252588192113577,FALSE
+"HCC44","Input","KEGG_PROPANOATE_METABOLISM",-0.37351,-1.1,0.299,8834,0.663,"ACSS2, ABAT, ACSS1",0.52432881167557,0.178486471595227,FALSE
+"HCC44","Input","KEGG_PROSTATE_CANCER",-0.47638,-1.39,0.123,7099,0.631,"PIK3CA, RAF1, CDKN1A, AKT2, CREBBP, CDK2, CASP9, MAPK1, TCF7L2, TCF7L1, MAPK3, CCND1, GRB2, ERBB2, BAD, SOS1, PDPK1, CTNNB1, GSK3B, PIK3CD, BCL2, RB1, FGFR1, GSTP1, TP53, LEF1",0.910094888560602,0.199970640755866,FALSE
+"HCC44","Input","KEGG_PROTEASOME",0.58921,1.8,0.0339,3061,0.458,"PSMB10, PSMB9, PSMB8, PSME1, PSMA6, PSME4, PSMB4, PSMC2, PSME2, PSME3, PSMD2, PSMA4, PSMC1, PSMB3, PSMC5, PSMA3, PSMA8, PSMD8, PSMD13, PSMD4, PSMA5, PSMD1, PSMD12, PSMC4, PSMA7, PSMD14, PSMD11, PSMC6, PSMA1, PSMD6, PSMC3, PSMD7, PSMF1, PSMB1, PSMB2, PSMD3",1.46980030179692,0.339134521996131,FALSE
+"HCC44","Input","KEGG_PROTEIN_EXPORT",0.34728,1.08,0.348,3320,0.631,"SEC61B, SEC61A1, SRP19, SRP72, SEC62, HSPA5, SRPRA, SRP68, OXA1L, SPCS1, SRP54, SEC63, SRPRB",0.458420756053419,0.199970640755866,FALSE
+"HCC44","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.59487,-1.72,0.0421,9114,0.452,"GLUD2",1.37571790416433,0.344861565188618,FALSE
+"HCC44","Input","KEGG_PURINE_METABOLISM",0.26579,0.802,0.669,1982,0.818,"FHIT, NT5E, POLR2I, PNP, PNPT1, ENPP1, AK4, GMPS, PFAS, HPRT1, POLR3G, PAICS, PRPS1, PRPS1L1, PDE6C, POLR1E, ADSL, POLR2K, GART, PPAT, GDA, NME7, DGUOK, PDE4D, NUDT5, GMPR2, APRT, ADK, PDE6D, ENTPD4",0.174573882232177,0.087246696328677,FALSE
+"HCC44","Input","KEGG_PYRIMIDINE_METABOLISM",0.22738,0.679,0.869,1354,0.939,"CDA, NT5E, UPP1, TXNRD1, POLR2I, PNP, TYMP, PNPT1, DHODH, POLR3G, POLR1E, AK3, POLR2K",0.0609802235513335,0.0273344077338891,FALSE
+"HCC44","Input","KEGG_PYRUVATE_METABOLISM",-0.22222,-0.637,0.914,8834,0.966,"ACSS2, ACSS1",0.0390538042661686,0.0150228735845067,FALSE
+"HCC44","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",0.25467,0.789,0.682,961,0.818,"RAC2, ITGB2, ITGA1, CFL2, ITGA2, MSN, MYH9, DIAPH2, ACTN1, MOS, FGF13, FGF2, SSH1, ACTN4, ITGA3, DIAPH3, ITGB3, PIP4K2A, ARHGEF1, ACTN2, ITGB1, LIMK1, ITGA5, VCL, MYLK, MYL12A, MYL9",0.166215625343521,0.087246696328677,FALSE
+"HCC44","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.47454,-1.37,0.139,6794,0.559,"GABARAPL1, GABARAPL2, ATG4D, ULK1, PRKAA1, ATG4B",0.856985199745905,0.252588192113577,FALSE
+"HCC44","Input","KEGG_RENAL_CELL_CARCINOMA",0.33432,1.03,0.375,181,0.65,"JUN, TGFB1, TGFA, VEGFA, TGFB2",0.425968732272281,0.187086643357144,FALSE
+"HCC44","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.35719,1.11,0.274,1130,0.622,"ANPEP, LNPEP, THOP1",0.562249437179612,0.206209615309181,FALSE
+"HCC44","Input","KEGG_RETINOL_METABOLISM",-0.47464,-1.38,0.128,7497,0.623,"RETSAT, PNPLA4, RDH16, ADH4, ADH7, CYP1A1, ADH5, ALDH1A1",0.892790030352132,0.20551195334083,FALSE
+"HCC44","Input","KEGG_RIBOFLAVIN_METABOLISM",0.46958,1.45,0.118,806,0.402,"ACP6, ENPP1",0.928117992693875,0.39577394691553,FALSE
+"HCC44","Input","KEGG_RIBOSOME",0.50097,1.57,0.0638,3274,0.364,"RPL37, RPL29, RPL24, RSL24D1, RPS25, RPL11, RPL27, RPL22, RPL18, RPL4, RPL38, RPL12, RPS7, RPL17, RPL32, RPL9, RPL26, RPL37A, RPL28, RPL30, FAU, RPL27A, RPL36, RPL5, RPS27L, MRPL13, RPL13, RPL14, RPL10A, RPS29, RPL3, RPL18A, RPL10, RPL15, RPL35A, RPSA, RPL34, RPL23, RPS16, RPS12, RPLP0, RPL7, RPL36A, RPL36AL, RPL21, RPS11, RPL19, RPL7A, RPS6, RPL23A, RPL13A, RPL6, RPS15A, RPLP1, RPS20, RPS28, RPS21, RPS24, RPS23, RPL35, RPS10, RPL8, RPS3A",1.19517932127884,0.438898616350944,FALSE
+"HCC44","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.16714,-0.494,0.992,5983,0.994,"RELA, MAPK10, IKBKB, MAP3K7, MAP3K1, MAPK14, IFIH1, MAPK13, MAPK12, CASP8, DDX58, FADD, TKFC",0.00348832784582135,0.00261361560268669,FALSE
+"HCC44","Input","KEGG_RNA_DEGRADATION",0.45354,1.42,0.114,1963,0.4,"EXOSC2, EXOSC9, DIS3, EXOSC1, PNPT1, DCPS, EXOSC5, EXOSC8, EXOSC6, EXOSC3, EXOSC7, DCP2, MTREX, EXOSC4, PAPOLA, ZCCHC7, EXOSC10, LSM6, MPHOSPH6, LSM2",0.943095148663527,0.397940008672038,FALSE
+"HCC44","Input","KEGG_RNA_POLYMERASE",0.3448,1.08,0.316,2931,0.631,"POLR2I, POLR3G, POLR1E, POLR2K, POLR3H, POLR1A, POLR3F, POLR3C",0.500312917381596,0.199970640755866,FALSE
+"HCC44","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.54971,1.73,0.045,2526,0.363,"CTH, GGT1, SCLY, CBS, AHCYL1, MAT2B, MARS2, AHCYL2, MAT1A, BUD23, MAT2A",1.34678748622466,0.440093374963888,FALSE
+"HCC44","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.40313,1.24,0.203,799,0.595,"PTGS2, TRAF1, MYC, FHIT, LAMC2, COL4A1, LAMB3, LAMB1, ITGA2, COL4A2, LAMA2, ITGA3, NFKB1, BIRC2, ITGB1",0.692503962086787,0.22548303427145,FALSE
+"HCC44","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.27597,0.867,0.559,1519,0.78,"STX11, VAMP5, BET1, VAMP3, STX10, STX16, VAMP8",0.252588192113577,0.10790539730952,FALSE
+"HCC44","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.28032,-0.812,0.678,8031,0.837,"ASAH1, DEGS1, NEU1, CERK, SMPD3, GALC",0.168770306132937,0.07727454200674,FALSE
+"HCC44","Input","KEGG_SPLICEOSOME",0.4694,1.46,0.0709,3621,0.436,"HNRNPU, THOC1, TXNL4A, SNRPB, DDX46, PRPF31, U2AF1, SNRNP40, NCBP2, SLU7, THOC2, DHX38, SNRNP70, PRPF40A, U2AF2, SNRPA1, CDC40, SNRPF, THOC3, DDX42, PRPF4, LSM6, PRPF6, NCBP1, RBM22, RBM17, DHX16, DDX39B, SNRPD3, PRPF38A, DDX23, CHERP, SMNDC1, LSM2, ZMAT2, PRPF38B, SNRNP27, SF3B6, SRSF8, ACIN1, ALYREF, RBM25, PPIE, DHX8, SRSF2, SNRPG, PRPF3, SNW1, HNRNPC, SNRPC, EFTUD2, SNRPA, SART1, PRPF8, HNRNPM, LSM8, SNU13, TCERG1, SF3B4, PHF5A, SRSF1, RBM8A, SNRNP200, SNRPD1, SNRPD2, CWC15, EIF4A3, SF3B5, SNRPB2, PQBP1, SF3A3, SF3B2, U2SURP, SF3B3, PRPF19, SRSF7, CTNNBL1, SF3A1, SYF2, BCAS2, SRSF3, HNRNPK, PLRG1, WBP11, HNRNPA3, HNRNPA1, PPIL1, SF3A2, TRA2B, SRSF5, MAGOHB",1.14935376481693,0.360513510731414,FALSE
+"HCC44","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",0.35956,1.12,0.287,1511,0.621,"PYGL, GCK, ENPP1, GUSB, GBE1, UGDH, UXS1",0.542118103266008,0.20690839982342,FALSE
+"HCC44","Input","KEGG_STEROID_BIOSYNTHESIS",-0.72797,-2.14,0.00327,7448,0.251,"LSS, HSD17B7, DHCR24, CYP51A1, CEL, LIPA, MSMO1, SQLE, SC5D, FDFT1",2.48545224733971,0.600326278518962,FALSE
+"HCC44","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.72218,-2.11,0.00818,7438,0.202,"CYP21A2, HSD17B7, AKR1C2, AKR1D1, AKR1C3, AKR1C1, STS, SULT2B1, CYP1A1, CYP11B1, HSD11B2",2.08724669632868,0.694648630553376,TRUE
+"HCC44","Input","KEGG_SULFUR_METABOLISM",-0.79031,-2.35,0,8714,0.132,"SULT2B1, SUOX, SULT1A1",Inf,0.87942606879415,TRUE
+"HCC44","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.44235,1.37,0.131,1123,0.412,"CD40, C3, ACTN1, ACTN4, ACTN2, SNRPB",0.882728704344236,0.385102783966865,FALSE
+"HCC44","Input","KEGG_TASTE_TRANSDUCTION",-0.3859,-1.13,0.289,8469,0.647,"SCNN1A, ASIC2",0.539102157243452,0.1890957193313,FALSE
+"HCC44","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.69095,-2.05,0.00859,7947,0.2,"IDI1, PMVK, HMGCR, MVK, HMGCS1",2.06600683616876,0.698970004336019,TRUE
+"HCC44","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",-0.25426,-0.748,0.799,7246,0.89,"CREBBP, MAPK1, SKP1, MAPK3, SMAD5, DCN, SMURF2, LTBP1, BMP6, INHBA, ACVR1, FST, THBS1",0.0974532206860086,0.0506099933550872,FALSE
+"HCC44","Input","KEGG_THYROID_CANCER",-0.53967,-1.59,0.0541,7376,0.396,"MAPK1, RXRA, TCF7L2, TCF7L1, MAPK3, CCND1, CDH1, RXRG, TPM3, CTNNB1, NCOA4, TP53, LEF1",1.26680273489343,0.402304814074488,FALSE
+"HCC44","Input","KEGG_TIGHT_JUNCTION",-0.389,-1.14,0.282,8009,0.657,"F11R, PRKCD, PATJ, TJP3, EPB41L1, CTNNA2, PARD6G, CTNNA1, LLGL2, SRC, CTNNB1, CGN, MPDZ, PRKCH, MYH14, MYH7B, EPB41L3, PRKCZ, CRB3, JAM3",0.549750891680639,0.182434630440219,FALSE
+"HCC44","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.2275,-0.664,0.89,7099,0.956,"PIK3CA, AKT2, MAPK13, MAPK1, SPP1, MAPK3, MAPK12, TOLLIP, CASP8, FADD, STAT1, IL6, MAP2K6, IFNAR1, PIK3CD, TLR3",0.0506099933550872,0.0195421077238999,FALSE
+"HCC44","Input","KEGG_TRYPTOPHAN_METABOLISM",0.28792,0.914,0.506,925,0.767,"KYNU, ALDH2, EHHADH, WARS2",0.295849483160201,0.115204636051019,FALSE
+"HCC44","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.48482,-1.41,0.106,6047,0.622,"PKLR, MAPK10, PKM, IKBKB, PIK3R1, PIK3R2, IRS1, INSR, PIK3CA, MAPK1, MAPK3, HK1, PRKCD, PIK3CD, PRKCZ",0.97469413473523,0.206209615309181,FALSE
+"HCC44","Input","KEGG_TYROSINE_METABOLISM",-0.42058,-1.22,0.223,7308,0.636,"ALDH3A1, LCMT1, MAOB, MAOA, TAT, DDC, ADH4, ADH7, ADH5",0.651695136951839,0.196542884351586,FALSE
+"HCC44","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.45108,-1.32,0.158,7081,0.608,"NFATC2, PIK3CA, RAF1, PPP3CC, TEC, PRKCQ, AKT2, PAK4, MAPK13, MAPK1, VAV2, MAPK3, MAPK12, NFKBIE, GRB2, PTPN6, PLCG1, SOS1, VAV3, PDPK1, PTPRC, NCK2, PAK5, PAK6, GSK3B, PIK3CD, PPP3R1",0.801342913045577,0.216096420727265,FALSE
+"HCC44","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.23239,-0.672,0.884,5967,0.956,"CUL5, UBA2, ANAPC7, UBE2D2, TRIM37, CUL4B, FBXW11, UBE2G1, DDB2, UBE2F, MAP3K1, UBE2J1, CUL3, UBE4B, FBXO2, NHLRC1, BTRC, UBA1, DDB1, SKP1, ANAPC4, COP1, FZR1, CDC20, UBE2R2, CUL7, HERC1, FBXW7, SMURF2, KEAP1, PIAS1, MGRN1, KLHL13, UBE2C",0.0535477349869269,0.0195421077238999,FALSE
+"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.28336,-0.848,0.633,7143,0.808,"IARS2, BCAT2",0.198596289982645,0.0925886392254138,FALSE
+"HCC44","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.21887,-0.649,0.894,8659,0.963,"ACADS, ABAT, HMGCS1",0.0486624812040823,0.0163737128754655,FALSE
+"HCC44","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.27061,-0.776,0.726,7010,0.861,"GNA13, PLCB2, GNAQ, RAF1, PRKCQ, ADCY9, PLCB3, MAPK1, ARHGEF12, MAPK3, GNA11, GNA12, KCNMA1, NPR2, ARHGEF11, PRKCD, CALM2, PRKCH, CALML3, PLCB4",0.139063379299906,0.0649968485463452,FALSE
+"HCC44","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.39997,-1.18,0.221,6986,0.679,"DYNLL2, DYNLL1, ADCY9, RAB5B, RAB11A, AVP, AQP3, ARHGDIB",0.655607726314889,0.168130225719498,FALSE
+"HCC44","Input","KEGG_VEGF_SIGNALING_PATHWAY",0.30469,0.959,0.424,170,0.735,"RAC2, PTGS2, PLA2G4A, VEGFA",0.372634143407267,0.133712660915805,FALSE
+"HCC44","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.25372,-0.739,0.772,6568,0.895,"KDELR3, ATP6V0D1, ATP6V1B2, ATP6V1A, ATP6V1E1, ATP6V1B1, ATP6V0A1, ATP6V1C2, ADCY9, ATP6V1H, ATP6V1F, ATP6V1C1, ATP6V1D, PLCG1, SLC12A2, PLCG2",0.112382699664264,0.048176964684088,FALSE
+"HCC44","Input","KEGG_VIRAL_MYOCARDITIS",0.46775,1.45,0.104,670,0.402,"RAC2, ITGB2, ICAM1, CD40, MYH11, MYH9, LAMA2, CD55",0.98296666070122,0.39577394691553,FALSE
+"HCC44","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.31185,-0.916,0.506,6099,0.741,"DVL3, CTBP1, MAPK10, SMAD2, FBXW11, AXIN1, PPP3CB, ROCK1, PPP2R5C, CHD8, MAP3K7, PPP2CA, EP300, PPP2R5E, PLCB1, APC, WNT5A, PPP2R5A, BTRC, CSNK1E, PPP2R5D, FZD1, PLCB2, NFATC2, PPP2R5B, PPP3CC, CAMK2B, CREBBP, WNT11, PLCB3, LRP6, TCF7L2, SKP1, TCF7L1, VANGL1, CCND1, CAMK2D, FZD6, DAAM1, CSNK1A1, CTNNB1, GSK3B, RAC3, VANGL2, PPP3R1, TP53, PLCB4, LEF1",0.295849483160201,0.130181792020672,FALSE
+"H1299","Input","KEGG_ABC_TRANSPORTERS",-0.27599,-0.866,0.601,8317,0.753,"ABCG2, ABCB6, ABCD3, ABCA2, ABCC2",0.22112552799726,0.123205023799299,FALSE
+"H1299","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.24869,-0.795,0.722,6104,0.86,"PIK3R2, RUNX1, KRAS, NRAS, KIT, PIK3R3, BRAF, MAPK3, GRB2, SOS1, STAT3, HRAS, STAT5A, TCF7L2, RPS6KB2, PIM1, TCF7L1, PIK3CD, CCND1, LEF1, CEBPA",0.141462802430361,0.0655015487564323,FALSE
+"H1299","Input","KEGG_ADHERENS_JUNCTION",-0.40719,-1.28,0.163,7299,0.344,"RAC1, PARD3, IGF1R, TCF7L2, WASF2, SRC, SORBS1, CREBBP, TCF7L1, EP300, LMO7, INSR, LEF1, ERBB2, PTPRM, ACTG1, BAIAP2, PTPN6, CTNNB1, CTNND1, NECTIN1, CTNNA1, CTNNA2, RAC2, CDH1",0.787812395596042,0.46344155742847,FALSE
+"H1299","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.34377,-1.1,0.308,8606,0.471,"IRS2, CAMKK1, ACSL1, NFKBIA, RXRG, RXRA, ACSL5, PRKCQ",0.511449283499556,0.326979092871104,FALSE
+"H1299","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",-0.512,-1.6,0.0677,8299,0.186,"GFPT1, GLUL, CPS1, ABAT, ASS1, GLUD2",1.16941133131486,0.730487055782084,FALSE
+"H1299","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.47784,-1.48,0.0829,7168,0.24,"ATP1A3, PDPK1, SFN, ATP1A1, SLC9A3R2, ATP1B3, ATP1A4, PIK3CD, ATP1B1, INSR, IRS2, HSD11B2",1.08144546944973,0.619788758288394,FALSE
+"H1299","Input","KEGG_ALPHA_LINOLENIC_ACID_METABOLISM",-0.73163,-2.35,0,8416,0.0459,"PLA2G12A, ACOX1, PLA2G4A, FADS2",Inf,1.33818731446274,TRUE
+"H1299","Input","KEGG_ALZHEIMERS_DISEASE",0.18642,0.584,0.958,3800,1,"TNFRSF1A, PLCB4, CYC1, BAD, COX6C, NDUFA9, PSEN1, CYCS, NDUFB4, UQCRQ, MME, GAPDH, NDUFS2, CAPN2, CHP1, NDUFB7, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, NDUFA4, NDUFC2, ITPR1, PPP3CC, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, ATP5PO, NDUFA6, NDUFA10, COX4I1, COX6B1, ITPR2, ATP5PB, NDUFB10, NDUFB9, GRIN1, NCSTN, SDHD, COX5A, ADAM17, UQCRC2, FADD, APAF1, NDUFB2, CASP9, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB",0.0186344909214556,0,FALSE
+"H1299","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.35339,1.12,0.27,1225,0.938,"RARS2, DARS2, YARS2, AARS2",0.568636235841013,0.0277971616209356,FALSE
+"H1299","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.26716,-0.841,0.638,7688,0.786,"GMPPA, UGDH, GMDS, HK1, CYB5R1, GFPT1, PGM1, MPI, UXS1, GALT, PMM2, GALE",0.195179321278838,0.104577453960592,FALSE
+"H1299","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.34158,1.08,0.313,1049,0.891,"NEFH, TNFRSF1A, PRPH, PRPH2, MAP2K3, TOMM40, BAD, NEFM, DAXX, CYCS",0.504455662453552,0.0501222959631252,FALSE
+"H1299","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.31939,-0.994,0.423,7289,0.593,"PSME2, CREB1, CTSB, B2M, PDIA3, PSME1, CANX, CD74, CALR, CTSS, IFI30",0.373659632624958,0.226945306635737,FALSE
+"H1299","Input","KEGG_APOPTOSIS",0.20589,0.646,0.912,1231,1,"TNFRSF1A, RIPK1, TNFRSF10A, IRAK4, BIRC2, ENDOG, BAD, EXOG, CYCS, AKT1, IRAK1",0.0400051616715838,0,FALSE
+"H1299","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.64437,-2.03,0.00374,8030,0.0989,"CBR1, GPX2, ALOX5, GGT1, PLA2G12A, GPX6, GPX7, CYP2J2, PTGS2, PTGES, PLA2G4A, EPHX2, GPX1",2.42712839779952,1.00480370840282,TRUE
+"H1299","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.54637,-1.73,0.0409,7582,0.138,"MAOA, ALDH18A1, PYCR3, OAT, ALDH3A2, GAMT, CKMT2, GLUL, PYCR1, PYCR2, AGMAT, GATM, ARG2, P4HA2, P4HA1, ALDH2, ARG1, MAOB, CPS1, ALDH1B1, ASS1, GLUD2",1.38827669199266,0.860120913598763,TRUE
+"H1299","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.37732,-1.18,0.227,8316,0.401,"ITGAV, LEF1, ACTG1, DSG2, ITGA7, PKP2, CTNNB1, ITGB4, GJA1, DSC2, CTNNA1, SGCD, CTNNA2, ITGB6",0.643974142806877,0.396855627379818,FALSE
+"H1299","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",-0.74763,-2.33,0.00184,7164,0.0408,"ALDH9A1, UGDH, ALDH3A2, ALDH2, ALDH1B1",2.73518217699046,1.38933983691012,TRUE
+"H1299","Input","KEGG_AXON_GUIDANCE",-0.4094,-1.27,0.177,8174,0.35,"PLXNB1, DPYSL2, PLXNB2, SEMA7A, SEMA4D, EPHB2, SEMA3A, EFNB2, EPHA1, UNC5B, SEMA6A, EPHA4, L1CAM, RAC2, ABLIM1, ABLIM3, PLXNA2, ABLIM2",0.752026733638193,0.455931955649724,FALSE
+"H1299","Input","KEGG_BASAL_CELL_CARCINOMA",-0.64483,-2.04,0.00929,7556,0.103,"TCF7L2, FZD7, GSK3B, APC, TCF7L1, SHH, LEF1, WNT16, CTNNB1, SUFU, TP53, WNT11",2.03198428600636,0.987162775294828,TRUE
+"H1299","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.23949,0.773,0.752,3786,1,"TAF2, TBP, GTF2I, TAF9B, GTF2A1, GTF2H4, GTF2A2, TAF6, TAF1, TAF5, TAF13",0.123782159408358,0,FALSE
+"H1299","Input","KEGG_BASE_EXCISION_REPAIR",-0.37405,-1.17,0.24,7169,0.398,"SMUG1, XRCC1, FEN1, NTHL1, LIG1, APEX1, MPG, APEX2, LIG3, PARP1, TDG",0.619788758288394,0.400116927926312,FALSE
+"H1299","Input","KEGG_BETA_ALANINE_METABOLISM",-0.58082,-1.9,0.0165,7164,0.102,"ALDH9A1, SRM, EHHADH, HIBCH, ALDH3A2, ALDH2, ABAT, ALDH1B1",1.78251605578609,0.991399828238082,TRUE
+"H1299","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.28374,0.888,0.557,786,1,"ELOVL2, ELOVL5, HACD1, ACOX3",0.254144804826271,0,FALSE
+"H1299","Input","KEGG_BLADDER_CANCER",-0.35677,-1.1,0.29,8433,0.471,"CCND1, THBS1, ERBB2, TP53, CDH1",0.537602002101044,0.326979092871104,FALSE
+"H1299","Input","KEGG_BUTANOATE_METABOLISM",-0.60337,-1.86,0.0221,8426,0.111,"HMGCS2, BDH2, HMGCS1, ACADS, BDH1, ALDH2, ABAT, ALDH1B1, ACSM3",1.65560772631489,0.954677021213343,TRUE
+"H1299","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.31263,-0.995,0.407,7871,0.598,"GSK3B, PIK3AP1, PIK3CD, BTK, PTPN6, SYK, NFKBIA, CD81, INPP5D, RAC2",0.39040559077478,0.223298816011589,FALSE
+"H1299","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.33568,-1.06,0.345,6674,0.516,"PPP3CB, CALML3, PHKA2, GNAS, ERBB4, CAMK2D, CAMK2G, ATP2B1, ADCY9, GNA11, ATP2A3, GNAQ, SLC25A4, PRKACB, ITPKB, LTB4R2, PTK2B, P2RX4, ATP2B2, ATP2B4, ERBB2, BST1, ERBB3, MYLK, PLCB1, TNNC1, CACNA1A, TNNC2",0.462180904926726,0.287350298372789,FALSE
+"H1299","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.36738,1.16,0.265,755,0.949,"TPM2, SLC8A1, CACNA2D1, SLC9A6, CYC1, COX6C",0.576754126063192,0.0227337875727074,FALSE
+"H1299","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.53518,-1.71,0.0519,8105,0.136,"CD58, NEO1, VCAM1, CD274, ITGAV, ITGB2, PTPRM, F11R, CNTN1, SDC3, NECTIN1, CLDN3, SDC1, CLDN4, CLDN6, ALCAM, L1CAM, CD276, SDC2, CDH1, NRCAM, CD99, CADM1, CDH15, CDH3, ICAM2, CLDN7",1.28483264215154,0.866461091629782,FALSE
+"H1299","Input","KEGG_CELL_CYCLE",0.33724,1.09,0.307,3160,0.966,"TGFB1, ESPL1, TTK, CDK6, CDK1, BUB1, CCNB1, PRKDC, ANAPC4, ORC3, ANAPC5, ORC4, CDC20, DBF4, CDC45, ORC5, CDC16, YWHAZ, CCNB2, ORC1, MYC, CHEK1, CDC27, ORC2, ANAPC1, PLK1, CDK7, ANAPC7, CDC23, MAD2L2, MCM7, SMC3, ANAPC2, YWHAB, MCM2, SMC1A, MAD1L1, YWHAQ, ANAPC10, CDC25C, SMC1B, CUL1, BUB1B, MCM6, MCM4, MCM5, RB1, SMAD3, TGFB2",0.512861624522813,0.0150228735845067,FALSE
+"H1299","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.31113,-0.977,0.431,6212,0.61,"KRAS, NRAS, PIK3R3, BRAF, CCR4, GNB2, MAPK3, GNG2, RHOA, ARRB2, STAT2, GRB2, GNB1, GNB4, SOS1, STAT3, CCL13, HRAS, WASL, ADCY9, CCL15, RAC1, PARD3, GNG10, VAV2, PREX1, PRKACB, GSK3B, STAT1, GNB3, PIK3CD, ELMO1, PTK2B, GRK2, PRKCD, NFKBIA, ADCY5, PLCB1, CCL20, RAC2, ARRB1",0.365522729839268,0.214670164989233,FALSE
+"H1299","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",0.19833,0.637,0.936,1929,1,"TGFB1, CDK6, CBL, BAD, AKT1, MYC, MECOM, SHC1, AKT2, CRK, AKT3",0.0287241512618947,0,FALSE
+"H1299","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.36967,-1.16,0.246,7037,0.406,"IDH3G, DLAT, SUCLA2, ACO2, ACLY, PCK2, SUCLG2, MDH1, SUCLG1, PC, IDH1, IDH2",0.609064892896621,0.391473966422806,FALSE
+"H1299","Input","KEGG_COLORECTAL_CANCER",-0.20836,-0.664,0.872,7871,0.969,"GSK3B, APC, TCF7L1, PIK3CD, CCND1, LEF1, CTNNB1, TP53, RAC2",0.0594835150674328,0.0136762229492347,FALSE
+"H1299","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.43013,-1.35,0.134,7894,0.301,"F8, SERPING1, C5, PROC, CD46, FGA, FGG, TFPI, FGB, PLG, F3, PROS1, SERPINA1, CD55, SERPINF2, A2M, C4A, SERPINC1",0.872895201635192,0.521433504406157,FALSE
+"H1299","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.26869,0.847,0.59,1334,1,"LDHB, CBS, DNMT1, SDS, CDO1, GOT1, SMS",0.229147988357856,0,FALSE
+"H1299","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.21322,0.683,0.88,605,1,"TGFB1, TNFRSF1A, CD70, TNFRSF10A, OSMR",0.0555173278498314,0,FALSE
+"H1299","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.30925,-0.961,0.46,8812,0.619,"NFKBIA, IL6, TREX1, IL18, PYCARD",0.337242168318426,0.208309350979882,FALSE
+"H1299","Input","KEGG_DILATED_CARDIOMYOPATHY",0.39562,1.26,0.202,211,0.884,"TGFB1, ITGA4, TPM2, SLC8A1, ITGA3, DES, CACNA2D1",0.694648630553376,0.0535477349869269,FALSE
+"H1299","Input","KEGG_DNA_REPLICATION",0.41963,1.35,0.134,3133,0.812,"PRIM1, PRIM2, POLA1, POLE, POLA2, POLE2, DNA2, RFC3, POLE3, RFC2, RFC5, RFC4, MCM7, MCM2, RNASEH2A, MCM6, MCM4, MCM5, RFC1",0.872895201635192,0.0904439707588247,FALSE
+"H1299","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.26076,0.831,0.618,6901,1,"ETS1, EGFR, NOTCH2, MAPK1, MAP2K1, ETV6, NOTCH3, NOTCH1, KRAS, MAPK3, GRB2, SOS1",0.209011524911184,0,FALSE
+"H1299","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.61305,-1.93,0.0165,8247,0.101,"GSTM3, CYP3A5, ALDH3A1, MGST3, GSTM4, GSTP1, MAOB, GSTM1, ALDH1A3, MGST1, GSTZ1, GSTT2",1.78251605578609,0.995678626217357,TRUE
+"H1299","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.33138,-1.04,0.381,8546,0.54,"CYP3A5, CES1, CES2, CDA",0.419075024324381,0.267606240177031,FALSE
+"H1299","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.54823,-1.73,0.0221,8277,0.138,"THBS4, COL2A1, ITGAV, THBS1, LAMA3, LAMA4, LAMA1, HSPG2, COL6A3, ITGA7, VTN, SDC3, ITGB4, COL5A1, LAMA5, COL1A2, LAMB1, TNC, COL1A1, COL4A1, COL3A1, AGRN, COL5A2, FN1, SDC1, SDC2, ITGB6, COL4A2",1.65560772631489,0.860120913598763,TRUE
+"H1299","Input","KEGG_ENDOCYTOSIS",-0.24244,-0.76,0.79,6194,0.885,"IQSEC1, KIT, HSPA2, ARAP1, ACAP3, IQSEC2, CHMP3, NEDD4L, FGFR3, ARRB2, EHD3, ARFGAP2, PIP5K1C, AP2S1, PRKCI, AGAP2, ERBB4, RAB11FIP5, CHMP2A, CLTCL1, SH3GL2, PIP4K2B, SH3GLB2, SMAP2, HRAS, EPS15, PARD3, STAM, AGAP1, IGF1R, CHMP4A, CHMP4B, STAMBP, RAB22A, RAB11FIP4, AP2A1, FGFR4, RAB5C, CBLB, SRC, LDLRAP1, CHMP4C, CHMP2B, GIT1, DAB2, DNAJC6, ARF6, EPN1, PARD6G, GRK2, ERBB3, PARD6B, DNM1, RAB11FIP1, ARRB1",0.102372908709559,0.0530567293021746,FALSE
+"H1299","Input","KEGG_ENDOMETRIAL_CANCER",-0.42658,-1.35,0.129,7871,0.301,"GSK3B, APC, TCF7L1, PIK3CD, CCND1, LEF1, ERBB2, CTNNB1, CTNNA1, CTNNA2, TP53, CDH1",0.889410289700751,0.521433504406157,FALSE
+"H1299","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.22248,-0.687,0.87,6283,0.963,"ADAM10, ATP6V0A1, ATP6V1G1, ATP6V0C, ATP6AP1, PLCG2, ATP6V1E1, MAPK8, TJP1, ATP6V1F, RAC1, ATP6V1C2, ATP6V0D1, SRC, GIT1, ATP6V0D2, F11R, NFKBIA, MAPK13",0.0604807473813815,0.0163737128754655,FALSE
+"H1299","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.18053,-0.574,0.966,6212,0.98,"KRAS, NRAS, PIK3R3, BRAF, MAPK3, PLCG2, MAPK8, GRB2, SOS1, MAP2K7, ERBB4, CAMK2D, CAMK2G, HRAS, NCK2, STAT5A, GAB1, ABL2, RPS6KB2, CBLB, GSK3B, SRC, EREG, PIK3CD, ERBB2, ERBB3, AREG",0.0150228735845067,0.00877392430750515,FALSE
+"H1299","Input","KEGG_ETHER_LIPID_METABOLISM",-0.50311,-1.6,0.0473,8097,0.186,"PAFAH2, PLA2G12A, LPCAT2, PLA2G4A, PLPP3",1.32513885926219,0.730487055782084,TRUE
+"H1299","Input","KEGG_FATTY_ACID_METABOLISM",-0.38803,-1.21,0.205,7905,0.38,"ALDH3A2, CPT2, GCDH, ACOX1, ACAA1, ACADS, ACSL1, ALDH2, ALDH1B1, ACSL5",0.688246138944246,0.42021640338319,FALSE
+"H1299","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.43435,-1.38,0.124,8251,0.297,"PIK3CD, PLA2G12A, BTK, SYK, PRKCD, PLA2G4A, MAPK13, INPP5D, RAC2, MAP2K6",0.906578314837765,0.527243550682788,FALSE
+"H1299","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.36011,-1.13,0.289,8251,0.44,"PIK3CD, ARF6, MARCKSL1, MARCKS, DNM1, SYK, PRKCD, SCIN, PLA2G4A, PLPP3, AMPH, INPP5D, RAC2",0.539102157243452,0.356547323513813,FALSE
+"H1299","Input","KEGG_FOCAL_ADHESION",-0.30779,-0.969,0.451,8251,0.611,"PIK3CD, THBS4, COL2A1, ITGAV, ARHGAP5, MYL9, FLNB, CCND1, THBS1, LAMA3, LAMA4, ERBB2, LAMA1, ACTG1, MYLK, COL6A3, ITGA7, VTN, CTNNB1, ITGB4, COL5A1, LAMA5, COL1A2, LAMB1, TNC, COL1A1, COL4A1, COL3A1, COL5A2, FN1, ITGB6, RAC2, COL4A2",0.345823458122039,0.213958789757446,FALSE
+"H1299","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.55745,-1.76,0.0378,8870,0.142,"QDPR, ALPI, ALPP",1.42250820016277,0.847711655616944,TRUE
+"H1299","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.55361,-1.72,0.0333,6901,0.139,"PFKL, PFKM, GMPPB, ALDOA, PFKFB3, PFKFB2, GMPPA, AKR1B1, GMDS, HK1, KHK, MPI, PFKFB4, ALDOC, PMM2",1.47755576649368,0.856985199745905,TRUE
+"H1299","Input","KEGG_GALACTOSE_METABOLISM",-0.54319,-1.67,0.0341,6901,0.154,"PFKL, PFKM, GANC, AKR1B1, HK1, GLB1, PGM1, GALT, GALE, GAA, B4GALT1",1.4672456210075,0.812479279163537,TRUE
+"H1299","Input","KEGG_GAP_JUNCTION",-0.19341,-0.616,0.942,6756,1,"GRB2, GNAS, SOS1, TJP1, TUBAL3, HRAS, ADCY9, GUCY1A1, GNA11, GNAQ, PRKACB, SRC, ADCY5, GJA1, PLCB1, TUBA4A",0.0259490972071227,0,FALSE
+"H1299","Input","KEGG_GLIOMA",-0.18458,-0.577,0.962,6104,0.986,"PIK3R2, KRAS, NRAS, PIK3R3, BRAF, MAPK3, PLCG2, CALML3, GRB2, SOS1, CAMK2D, CAMK2G, HRAS, IGF1R, CDK4, PIK3CD, CCND1, TP53",0.0168249279621871,0.0061230850587888,FALSE
+"H1299","Input","KEGG_GLUTATHIONE_METABOLISM",-0.55513,-1.73,0.0399,8136,0.138,"G6PD, GPX2, GSTM3, GGT1, GPX6, GPX7, GSR, MGST3, GSTM4, GSTP1, IDH1, GSTM1, MGST1, GSTZ1, GSTT2, IDH2, GPX1",1.39902710431325,0.860120913598763,TRUE
+"H1299","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.42507,-1.34,0.151,6839,0.306,"DGKA, AGPAT2, TKFC, ALDH9A1, CEL, DGKD, DGKZ, AKR1B1, ALDH3A2, LIPG, ALDH2, MGLL, PLPP3, LIPC, LPL, AKR1A1, ALDH1B1",0.821023052706831,0.51427857351842,FALSE
+"H1299","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.27765,-0.865,0.616,6836,0.747,"PTDSS1, DGKA, MBOAT7, AGPAT2, CHKB, CDS1, GPD1L, LYPLA2, CDIPT, CDS2, CHKA, DGKD, DGKZ, LPGAT1, PEMT, GNPAT, PLA2G12A, LPCAT2, PLA2G4A, PLPP3",0.210419287835575,0.126679398184601,FALSE
+"H1299","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.38232,-1.18,0.253,6692,0.401,"PSPH, SHMT1, SHMT2, AGXT, MAOA, GCAT, PHGDH, SRR, GAMT, SARDH, CTH, GATM, CHDH, MAOB",0.596879478824182,0.396855627379818,FALSE
+"H1299","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.39076,-1.24,0.181,6901,0.352,"PFKL, PFKM, ACSS2, DLAT, ALDH9A1, BPGM, ALDOA, GALM, PGAM2, PCK2, ALDH3A2, HK1, LDHA, PGM1, ALDH3A1, ACSS1, ALDOC, ALDH2, ALDH1A3, AKR1A1, ALDH1B1",0.742321425130815,0.453457336521869,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.4068,-1.3,0.161,7049,0.338,"CHST11, B3GAT3, CHPF, CHST13, CHST12, XYLT1",0.79317412396815,0.471083299722345,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.40611,-1.29,0.178,8371,0.344,"GLCE, XYLT1, HS6ST2",0.749579997691106,0.46344155742847,FALSE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.76407,-2.45,0,7570,0.0398,"B4GALT3, B4GAT1, B3GNT2, ST3GAL1, B4GALT4, B4GALT1",Inf,1.40011692792631,TRUE
+"H1299","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.33106,-1.06,0.344,7666,0.516,"IDS, IDUA, GLB1, HGSNAT, NAGLU",0.46344155742847,0.287350298372789,FALSE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.41618,-1.32,0.139,8864,0.322,"ST3GAL1",0.856985199745905,0.492144128304169,FALSE
+"H1299","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.74034,-2.36,0.00177,7570,0.0569,"B4GALT3, B4GAT1, B3GNT3, B3GNT2, ST3GAL6, ST3GAL4, B4GALT4, B4GALT1",2.75202673363819,1.24488773360493,TRUE
+"H1299","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.19378,-0.61,0.952,7000,0.998,"PIGO, PIGU, PIGS, PIGQ",0.0213630516155257,0.000869458712628891,FALSE
+"H1299","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.4821,1.54,0.0872,1618,0.659,"MTHFD1L, MTHFD2L, HYI, MTHFD2, MDH2, CS",1.05948351506743,0.18111458540599,FALSE
+"H1299","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.31871,-1.03,0.395,6707,0.55,"CALML3, MAPK8, GRB2, GNAS, SOS1, MAP2K7, CAMK2D, CAMK2G, HRAS, ADCY9, GNA11, GNAQ, PRKACB, MAP3K1, SRC, MMP14, PTK2B, PLA2G12A, PRKCD, ADCY5, PLCB1, PLA2G4A, MAPK13, MAP2K6",0.40340290437354,0.259637310505756,FALSE
+"H1299","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.64355,-2.01,0.0148,7408,0.0872,"CSNK1E, PRKACB, GSK3B, SHH, WNT16, SUFU, WNT11",1.82973828460504,1.05948351506743,TRUE
+"H1299","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.4814,1.52,0.0808,1229,0.605,"ITGA4, ITGA3, CD44, ANPEP, CD59, ITGA6, ITGA5, MME, CD9",1.09258863922541,0.218244625347531,FALSE
+"H1299","Input","KEGG_HISTIDINE_METABOLISM",-0.58082,-1.83,0.0149,7582,0.117,"MAOA, ALDH3A2, HNMT, DDC, ALDH3A1, ALDH2, MAOB, ALDH1A3, ALDH1B1",1.82681373158773,0.931814138253838,TRUE
+"H1299","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.51928,1.68,0.0523,1324,0.488,"RAD51C, RAD52, SEM1, TOP3A, BLM, RAD50, NBN, MRE11",1.28149831113273,0.311580177997289,FALSE
+"H1299","Input","KEGG_HUNTINGTONS_DISEASE",0.16839,0.547,0.982,4015,1,"PLCB4, CYC1, COX6C, NDUFA9, POLR2B, CYCS, NDUFB4, UQCRQ, TBP, NDUFS2, DLG4, POLR2K, NDUFB7, POLR2A, RCOR1, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, TGM2, TFAM, POLR2G, HIP1, DCTN1, NDUFA4, NDUFC2, ITPR1, GRM5, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, DCTN2, ATP5PO, NDUFA6, NDUFA10, COX4I1, COX6B1, POLR2E, POLR2I, ATP5PB, NDUFB10, NDUFB9, GRIN1, SDHD, COX5A, POLR2J, UQCRC2, POLR2C, SIN3A, IFT57, HDAC2, APAF1, NDUFB2, CASP9, CLTC, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB, SLC25A31, NDUFV1, ATP5F1A, HTT, DCTN4, UQCRH, VDAC2, ATP5F1C",0.00788851221305034,0,FALSE
+"H1299","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.38084,1.24,0.21,211,0.863,"TGFB1, ITGA4, TPM2, SLC8A1, ITGA3, DES, CACNA2D1",0.677780705266081,0.0639892042847904,FALSE
+"H1299","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.30975,0.97,0.427,999,1,"ISYNA1, IMPA1, PLCB4, SYNJ2, SYNJ1, INPP5K, INPP4B",0.369572124974976,0,FALSE
+"H1299","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.21631,-0.684,0.863,5890,0.959,"CALM2, CRKL, PPP1CB, PPP1R3D, IKBKB, PTPRF, PIK3R2, PHKG2, KRAS, NRAS, HK2, PHKB, PIK3R3, PRKAR2B, HK3, BRAF, PYGB, MAPK3, CALML3, MAPK8, PRKCI, PHKA2, GRB2, SOS1, PRKAR1A, PRKAR1B, HRAS, PYGL, EXOC7, PDPK1, FLOT1, PDE3A, PCK2, RPS6KB2, CBLB, PRKACB, GSK3B, MKNK1, FOXO1, HK1, SORBS1, FLOT2, PRKAA2, PIK3CD, INSR, IRS2, GYS1, INPP5D",0.0639892042847904,0.0181813928293364,FALSE
+"H1299","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",0.59836,1.9,0.0156,49,1,"TGFB1, ITGA4",1.80687540164554,0,FALSE
+"H1299","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.22286,-0.693,0.861,6637,0.962,"STAT2, LIFR, GRB2, SOS1, STAT3, IFNAR1, STAM, STAT5A, PIM1, CBLB, STAT1, CREBBP, IL13RA1, EP300, PIK3CD, CCND1, IRF9, PTPN6, STAT6, IL6",0.0649968485463452,0.0168249279621871,FALSE
+"H1299","Input","KEGG_LEISHMANIA_INFECTION",0.30283,0.979,0.466,536,1,"TGFB1, ITGA4, JUN, MAP3K7, IRAK4",0.33161408331,0,FALSE
+"H1299","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.3717,-1.17,0.242,8232,0.398,"VCAM1, PIK3CD, ARHGAP5, MYL9, PTK2B, ITGB2, F11R, ACTG1, CTNNB1, CTNND1, CLDN3, CTNNA1, CLDN4, CTNNA2, CLDN6, MAPK13, RAC2, CD99, CLDN7",0.616184634019569,0.400116927926312,FALSE
+"H1299","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",-0.65603,-2.06,0.00719,7164,0.105,"ALDH9A1, EHHADH, ALDH3A2, ALDH2, ALDH1B1",2.14327110961712,0.978810700930062,TRUE
+"H1299","Input","KEGG_LINOLEIC_ACID_METABOLISM",-0.79212,-2.53,0,8416,0.041,"PLA2G12A, CYP3A5, CYP2J2, PLA2G4A",Inf,1.38721614328026,TRUE
+"H1299","Input","KEGG_LONG_TERM_DEPRESSION",-0.31337,-0.975,0.426,6212,0.607,"KRAS, NRAS, BRAF, PLA2G12B, MAPK3, RYR1, GUCY1B1, GNAS, HRAS, GUCY1A1, GNA11, IGF1R, GNAQ, GNA13, PLA2G12A, GNAO1, PLCB1, CACNA1A, PLA2G4A",0.370590400897281,0.216811308924742,FALSE
+"H1299","Input","KEGG_LONG_TERM_POTENTIATION",0.15912,0.513,0.991,199,1,"ATF4, PLCB4",0.00392634551472468,0,FALSE
+"H1299","Input","KEGG_LYSINE_DEGRADATION",-0.19376,-0.612,0.951,7905,1,"ALDH3A2, GCDH, PLOD1, PLOD2, ALDH2, ALDH1B1",0.0218194830625861,0,FALSE
+"H1299","Input","KEGG_LYSOSOME",-0.39391,-1.25,0.191,7548,0.345,"LAMP1, CTSB, IDS, IDUA, GNPTAB, ATP6V0D1, PPT1, GNPTG, GGA2, SORT1, GM2A, AP1M2, AP3S2, GLB1, CTSZ, LAMP2, GBA, NAPSA, ATP6V0D2, SUMF1, ABCA2, FUCA1, ENTPD4, CTSS, SCARB2, HGSNAT, SLC11A2, ASAH1, NAGLU, GAA, ARSA, CTSH",0.718966632752272,0.462180904926726,FALSE
+"H1299","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26656,0.817,0.652,445,1,"TGFB1, FLNC, RELB, FGF13, FGF2, ATF4, TNFRSF1A, NFKB2, CACNA2D1, FGFR1, MAP2K3, JUN, MAP3K7",0.18575240426808,0,FALSE
+"H1299","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.63279,-2.02,0.00361,7212,0.0958,"HES1, HNF1B, MNX1, IAPP, NEUROD1, HNF1A, HNF4A, FOXA2",2.44249279809434,1.01863449092146,TRUE
+"H1299","Input","KEGG_MELANOGENESIS",-0.50213,-1.58,0.0615,7032,0.189,"CAMK2D, CAMK2G, HRAS, ADCY9, CREB1, ASIP, TCF7L2, GNAQ, FZD7, PRKACB, GSK3B, CREBBP, KITLG, TCF7L1, EP300, LEF1, GNAO1, DCT, WNT16, CREB3L2, CTNNB1, ADCY5, MITF, TYRP1, PLCB1, WNT11",1.21112488422458,0.723538195826756,FALSE
+"H1299","Input","KEGG_MELANOMA",0.32989,1.07,0.314,235,0.872,"FGF13, FGF2, CDK6, FGFR1",0.503070351926785,0.0594835150674328,FALSE
+"H1299","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.59808,-1.88,0.0199,8139,0.108,"CYP1B1, GSTM3, CYP3A5, ALDH3A1, MGST3, GSTM4, GSTP1, CYP2S1, EPHX1, GSTM1, ALDH1A3, MGST1, GSTZ1, GSTT2",1.70114692359029,0.96657624451305,TRUE
+"H1299","Input","KEGG_MISMATCH_REPAIR",0.25847,0.838,0.674,3817,1,"RFC3, RFC2, RFC5, PMS2, RFC4, MSH3, RFC1, MSH6, RPA2, SSBP1, MSH2",0.17134010346468,0,FALSE
+"H1299","Input","KEGG_MTOR_SIGNALING_PATHWAY",0.15967,0.511,0.989,2192,1,"ULK1, AKT1, ULK3, RICTOR, RPS6KB1, AKT2, AKT3, RPTOR, RPS6, PRKAA1, MTOR",0.0048037084028206,0,FALSE
+"H1299","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.23437,-0.728,0.81,6099,0.923,"PPP3CA, PIK3R2, KRAS, NRAS, IFNAR2, PIK3R3, BRAF, TNFRSF10B, MAPK3, BID, PLCG2, PPP3CB, GRB2, TNFRSF10D, SOS1, IFNAR1, RAET1L, ULBP2, HRAS, RAC1, VAV2, PIK3CD, LCK, PTK2B, ITGB2, PTPN6, SYK, RAC2, ICAM2",0.0915149811213502,0.0347982989740879,FALSE
+"H1299","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.23196,-0.726,0.809,6550,0.918,"F2, TSPO, PARD3, LTB4R2, PLG, P2RX4",0.0920514783877277,0.0371573187987575,FALSE
+"H1299","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.21115,-0.678,0.864,6212,0.959,"KRAS, NRAS, MAP3K3, PIK3R3, RPS6KA6, ARHGDIA, BRAF, MAPK3, RHOA, PLCG2, RPS6KA3, YWHAH, CALML3, MAPK8, BAX, GRB2, SOS1, MAP2K7, CAMK2D, CAMK2G, HRAS, MAP3K5, RAC1, RPS6KA5, PDPK1, GAB1, MAPKAPK2, RPS6KA4, MAP3K1, GSK3B, SORT1, RPS6KA2, ARHGDIB, PIK3CD, RPS6KA1, IRS2, PRKCD, NFKBIA, MAPK13, NGFR, TP53",0.0634862575211067,0.0181813928293364,FALSE
+"H1299","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.50481,-1.56,0.0524,8445,0.193,"PNP, BST1, NNMT, NNT, NUDT12, QPRT",1.28066871301627,0.714442690992226,FALSE
+"H1299","Input","KEGG_NITROGEN_METABOLISM",-0.43691,-1.4,0.119,7711,0.283,"CA2, CA5B, CA12, GLUL, CTH, CPS1, GLUD2",0.924453038607469,0.54821356447571,FALSE
+"H1299","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.28592,-0.906,0.528,8812,0.699,"NFKBIA, IL6, IL18, MAPK13, PYCARD",0.277366077466188,0.155522824254319,FALSE
+"H1299","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.4647,1.48,0.0933,1324,0.603,"PRKDC, RAD50, MRE11",1.0301183562535,0.219682687859849,FALSE
+"H1299","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.25345,-0.795,0.7,8251,0.86,"PIK3CD, CCND1, ERBB2, FHIT, RXRG, RXRA, TP53",0.154901959985743,0.0655015487564323,FALSE
+"H1299","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.28057,-0.878,0.583,7134,0.737,"NCOR2, MAML2, HES1, CTBP2, CREBBP, EP300, DTX3L, JAG1, JAG2",0.234331445240986,0.132532512140949,FALSE
+"H1299","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.21893,0.691,0.846,2833,1,"POLE, POLE2, RFC3, POLE3, RFC2, RFC5, CDK7, RFC4, ERCC2, XPA, GTF2H4, ERCC3",0.0726296369609765,0,FALSE
+"H1299","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.34236,-1.07,0.322,7512,0.512,"MAN1B1, B4GALT3, MAN1A2, ALG12, ALG13, MGAT5, B4GALT1, MGAT4A, ST6GAL1",0.492144128304169,0.290730039024169,FALSE
+"H1299","Input","KEGG_OLFACTORY_TRANSDUCTION",0.224,0.724,0.821,1062,1,"PDE1C, CNGB1",0.0856568428805592,0,FALSE
+"H1299","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.35284,1.13,0.295,2549,0.971,"MTHFD1L, MTHFD2L, MTHFD2, TYMS, GART, MTHFD1",0.530177984021837,0.0127807700919951,FALSE
+"H1299","Input","KEGG_OOCYTE_MEIOSIS",0.3392,1.08,0.317,2416,0.891,"STAG3, ESPL1, CDK1, BUB1, CCNB1, ANAPC4, PPP2R5E, PPP2R5D, PPP2R5C, ANAPC5, CDC20, PPP2R1B, SGO1, CDC16, YWHAZ, CCNB2, CDC27, CHP1, ANAPC1, PLK1, PPP1CC, ANAPC7, PPP1CA, CDC23, MAD2L2, SLK, SMC3, ANAPC2, ITPR1, PPP3CC, YWHAB",0.498940737782249,0.0501222959631252,FALSE
+"H1299","Input","KEGG_OTHER_GLYCAN_DEGRADATION",-0.44465,-1.4,0.0998,7614,0.283,"FUCA2, GLB1, GBA, FUCA1",1.00086945871263,0.54821356447571,FALSE
+"H1299","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.22338,0.708,0.834,3800,1,"CYC1, COX15, COX6C, NDUFA9, NDUFB4, UQCRQ, NDUFS2, NDUFB7, NDUFA11, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, COX11, NDUFA4, NDUFC2, NDUFS3, UQCRFS1, ATP6V0A2, NDUFA5, NDUFA2, ATP6V1D, ATP5PO, ATP6V1C1, NDUFA6, NDUFA10, COX4I1, COX6B1, ATP5PB, NDUFB10, NDUFB9, SDHD, COX5A, ATP5MG, UQCRC2, NDUFB2, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB",0.0788339493622613,0,FALSE
+"H1299","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.71766,-2.27,0.00183,7307,0.0442,"GALNT14, GALNT15, GALNT13, GALNT7, B3GNT6, GALNT1, GALNT6, B4GALT5, GALNT2, GALNT5, ST3GAL1, GALNT3, GALNT12",2.73754891026957,1.35457773065091,TRUE
+"H1299","Input","KEGG_P53_SIGNALING_PATHWAY",0.24681,0.8,0.727,1843,1,"SERPINE1, STEAP3, CDK6, CDK1, CCNB1, CD82, CYCS, CCNB2, CHEK1, RRM2B, RRM2, GTSE1",0.138465589140962,0,FALSE
+"H1299","Input","KEGG_PANCREATIC_CANCER",-0.19446,-0.606,0.94,7916,0.993,"CDK4, STAT1, ARHGEF6, PIK3CD, CCND1, ERBB2, TP53, RAC2",0.0268721464003014,0.00305075150461883,FALSE
+"H1299","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41145,-1.28,0.167,6012,0.344,"COASY, PPCS, PANK3, PANK2, BCAT2, ENPP1, PANK1",0.777283528852417,0.46344155742847,FALSE
+"H1299","Input","KEGG_PARKINSONS_DISEASE",0.27221,0.879,0.564,4015,1,"UCHL1, CYC1, COX6C, HTRA2, NDUFA9, CYCS, NDUFB4, UQCRQ, NDUFS2, UBE2G1, NDUFB7, NDUFS7, COX7B, NDUFB5, NDUFS5, NDUFB3, NDUFA4, NDUFC2, NDUFS3, UQCRFS1, CASP3, NDUFA5, NDUFA2, ATP5PO, NDUFA6, NDUFA10, COX4I1, UBE2J2, COX6B1, ATP5PB, NDUFB10, NDUFB9, SDHD, COX5A, UQCRC2, APAF1, NDUFB2, CASP9, NDUFA8, ATP5PF, NDUFC1, NDUFB6, ATP5F1B, COX6A1, SDHC, UQCR10, UQCRB, SLC25A31, NDUFV1, ATP5F1A, UQCRH, VDAC2, ATP5F1C",0.248720896016658,0,FALSE
+"H1299","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.2403,-0.771,0.749,8587,0.873,"ACTG1, CTNNB1, TUBA4A, CDH1",0.125518182300534,0.0589857562944303,FALSE
+"H1299","Input","KEGG_PATHWAYS_IN_CANCER",-0.28055,-0.897,0.569,7701,0.708,"LAMB3, LAMC1, CBLB, FZD7, ARNT, EGLN1, GSK3B, CDK4, STAT1, FOXO1, CREBBP, APC, KITLG, TCF7L1, TRAF5, SHH, EP300, PIK3CD, SKP2, ITGAV, CCND1, LAMA3, LAMA4, NCOA4, LEF1, ERBB2, LAMA1, PTGS2, WNT16, AR, CTNNB1, NFKBIA, LAMA5, SUFU, MITF, GSTP1, CEBPA, IL6, LAMB1, COL4A1, CTNNA1, RXRG, TRAF4, FN1, CTNNA2, RXRA, TP53, RAC2, COL4A2, CDH1, WNT11",0.244887733604929,0.149966742310231,FALSE
+"H1299","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.63939,-2.01,0.00717,5961,0.0872,"UGP2, GUSB, RPE, XYLB, UGDH, AKR1B1, CRYL1, DCXR",2.1444808443322,1.05948351506743,TRUE
+"H1299","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.49597,-1.57,0.0581,6410,0.191,"PRPS1, PRPS1L1, DERA, PFKL, PFKM, ALDOA, H6PD, PGD, G6PD, TALDO1, TKT, PGM1, ALDOC",1.23582386760967,0.718966632752272,FALSE
+"H1299","Input","KEGG_PEROXISOME",-0.44561,-1.37,0.134,7248,0.296,"GSTK1, AGXT, EHHADH, MVK, SCP2, PEX13, HSD17B4, GNPAT, DECR2, AMACR, PHYH, ABCD3, PECR, ACOX1, ACAA1, ACSL1, DHRS4, IDH1, NUDT12, EPHX2, ACSL5, IDH2",0.872895201635192,0.528708288941061,FALSE
+"H1299","Input","KEGG_PHENYLALANINE_METABOLISM",-0.60771,-1.93,0.0162,6665,0.101,"ALDH3B1, PRDX6, PAH, MIF, MAOA, DDC, ALDH3A1, MAOB, ALDH1A3",1.79048498545737,0.995678626217357,TRUE
+"H1299","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",0.21024,0.65,0.89,999,1,"DGKE, IMPA1, PLCB4, SYNJ2, SYNJ1, INPP5K, INPP4B",0.0506099933550872,0,FALSE
+"H1299","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",-0.32269,-1.02,0.368,7998,0.561,"HMBS, FTH1, UROS, CP",0.434152181326482,0.251037138743839,FALSE
+"H1299","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.50039,-1.58,0.0568,7013,0.189,"SLC27A1, RXRB, ACOX2, APOA1, EHHADH, PDPK1, PCK2, SCP2, CPT2, SORBS1, OLR1, HMGCS2, CYP27A1, FABP7, ACOX1, ACAA1, ACSL1, FABP3, ME1, RXRG, APOA2, LPL, RXRA, ACSL5, FABP1, FADS2",1.24565166428898,0.723538195826756,FALSE
+"H1299","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.72431,-2.26,0.00538,7780,0.0412,"SCP2, HSD17B4, AMACR, CYP27A1, CYP7B1, HSD3B7",2.26921772433361,1.38510278396687,TRUE
+"H1299","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.37526,-1.2,0.236,8065,0.387,"ADA, LCK, BTK",0.627087997029893,0.412289034981089,FALSE
+"H1299","Input","KEGG_PRION_DISEASES",-0.39415,-1.26,0.184,5965,0.344,"NOTCH1, SOD1, MAPK3, BAX, HSPA5, C9, NCAM1, LAMC1, PRKACB, C5, IL6",0.735182176990464,0.46344155742847,FALSE
+"H1299","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",0.23397,0.747,0.766,2064,1,"HSP90AA1, CDK1, BUB1, CCNB1, ANAPC4, ANAPC5, AKT1, HSP90AB1, CDC16, CCNB2, CDC27, ANAPC1, PLK1, AKT2, AKT3, ANAPC7, CDC23, MAD2L2",0.115771230367396,0,FALSE
+"H1299","Input","KEGG_PROPANOATE_METABOLISM",-0.61286,-1.96,0.00187,7127,0.104,"ACSS2, ALDH9A1, SUCLA2, EHHADH, SUCLG2, SUCLG1, HIBCH, ALDH3A2, LDHA, PCCA, ACSS3, ALDH6A1, ACSS1, PCCB, ALDH2, ABAT, ALDH1B1, MCEE",2.7281583934635,0.98296666070122,TRUE
+"H1299","Input","KEGG_PROSTATE_CANCER",-0.30791,-0.948,0.463,6891,0.636,"HSP90B1, SOS1, CREB5, HRAS, CREB1, PDPK1, IGF1R, TCF7L2, GSK3B, FOXO1, CREBBP, TCF7L1, EP300, PIK3CD, CCND1, LEF1, ERBB2, AR, CREB3L2, CTNNB1, NFKBIA, GSTP1, TP53",0.334419008982047,0.196542884351586,FALSE
+"H1299","Input","KEGG_PROTEASOME",0.21338,0.678,0.867,4175,1,"SEM1, PSMC1, POMP, PSMB5, PSMC2, PSMD4, PSMD6, PSME4, PSMB4, PSMB7, PSMD1, PSMB6, PSMB2, PSMD13, PSMD8, PSMD11, PSMC5, PSMA8, PSMF1, PSMD12, PSMD3, PSMD14, PSMA4, PSMB1, PSMD7, PSMD2, PSMC6, PSMC4, PSMA1, PSMA2, PSMA3",0.0619809025237897,0,FALSE
+"H1299","Input","KEGG_PROTEIN_EXPORT",0.22507,0.723,0.797,2880,1,"SEC63, SRPRA, OXA1L, SRPRB, SRP14, IMMP2L",0.0985416786038876,0,FALSE
+"H1299","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.65934,-2.07,0.00365,7168,0.111,"ATP1A3, ATP1A1, SLC25A10, PCK2, ATP1B3, CA2, MDH1, ATP1A4, AQP1, ATP1B1, GLUD2",2.43770713554353,0.954677021213343,TRUE
+"H1299","Input","KEGG_PURINE_METABOLISM",0.15772,0.492,0.993,2599,0.995,"NT5E, PRIM1, NME6, POLR1E, PRIM2, POLA1, POLE, ADCY10, POLA2, POLE2, PDE1C, POLR2B, NME1, HPRT1, POLE3, POLR2K, RRM2B, POLR2A, PDE6D, RRM2, NT5C3A, GART, POLR2G, NUDT2, PFAS, PNPT1, DGUOK, NME2, GMPS, NT5C2, PDE6C, GMPR2",0.00305075150461883,0.00217691925427455,FALSE
+"H1299","Input","KEGG_PYRIMIDINE_METABOLISM",0.27474,0.871,0.561,1879,1,"NT5E, PRIM1, NME6, POLR1E, DHODH, PRIM2, POLA1, POLE, POLA2, POLE2, POLR2B, NME1, UMPS, UCKL1, TXNRD2, POLE3, DUT, POLR2K, RRM2B, POLR2A, TYMS, RRM2, NT5C3A",0.251037138743839,0,FALSE
+"H1299","Input","KEGG_PYRUVATE_METABOLISM",-0.39668,-1.26,0.172,7127,0.344,"ACSS2, DLAT, ALDH9A1, PCK2, MDH1, AKR1B1, ALDH3A2, PC, LDHA, HAGH, ACSS1, ME1, ALDH2, ALDH1B1",0.764471553092451,0.46344155742847,FALSE
+"H1299","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.18943,-0.593,0.957,7119,0.985,"PIP4K2B, ITGB3, PIP4K2A, HRAS, WASL, RAC1, ITGA2B, CFL1, VAV2, ITGA1, CYFIP2, ITGB8, FGFR4, GNA13, BRK1, WASF2, ARHGAP35, IQGAP2, ARHGEF6, APC, FGD1, GIT1, PIK3CD, ITGAV, MYL9, ITGB2, ACTG1, BAIAP2, MYLK, ITGA7, MYH14, ITGB4, SCIN, ENAH, FN1, DIAPH2, ITGB6, RAC2",0.0190880622231565,0.00656376950238827,FALSE
+"H1299","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.54176,1.73,0.037,2579,0.675,"GABARAPL2, ULK1, ATG7, GABARAPL1, ATG5, PIK3R4, ULK3, ATG12, PRKAA1, ATG4B, PIK3C3, ATG3",1.431798275933,0.170696227168975,FALSE
+"H1299","Input","KEGG_RENAL_CELL_CARCINOMA",0.25385,0.826,0.631,1929,1,"TGFB1, PAK4, JUN, RAP1B, ETS1, AKT1, FH, AKT2, FLCN, CRK, AKT3",0.199970640755866,0,FALSE
+"H1299","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.41002,1.32,0.146,3212,0.804,"ANPEP, MME, MAS1, THOP1, CTSA, ACE, LNPEP",0.835647144215563,0.0947439512515487,FALSE
+"H1299","Input","KEGG_RETINOL_METABOLISM",-0.47988,-1.54,0.0662,8546,0.204,"CYP3A5, PNPLA4, DHRS4, ALDH1A1, ALDH1A2",1.1791420105603,0.690369832574101,FALSE
+"H1299","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.45108,-1.4,0.117,7317,0.283,"ACP5, FLAD1, ENPP1, ACP6",0.931814138253838,0.54821356447571,FALSE
+"H1299","Input","KEGG_RIBOSOME",0.5487,1.77,0.0288,3176,0.874,"RPL22, RPL26L1, RPL7, RPL8, RPL6, RPS23, RPL14, RPL28, RPL29, RPL19, RPL7A, RPS8, RPL36, RPS11, RPL37A, FAU, RPL26, RPL17, RPL23A, RPL34, RPL15, RPL36A, RPL36AL, RPL35A, RPS3A, RPL18, RPL21, RPL10A, RPL32, RPL13A, RPL4, RPL38, RPS6, RPS18, RPL27A, RPS13, RPL31, RPL23, RPS9, RPS29, RPS5, UBA52, RPS24, RPL30, RPL9, RPL37, RPS4X, RPS12, RPS15, RPS19, RPS25, RPL24, RSL24D1, MRPL13, RPL13, RPS17, RPL18A, RPL5, RPL3, RPL27, RPL35, RPL10, RPS2, RPS15A",1.54060751224077,0.058488567365597,FALSE
+"H1299","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.25725,-0.793,0.689,7646,0.856,"ISG15, MAP3K1, SIKE1, MAVS, CYLD, NFKBIA, DDX3Y, MAPK13, CASP10",0.161780778092374,0.0675262353228468,FALSE
+"H1299","Input","KEGG_RNA_DEGRADATION",0.22372,0.705,0.821,3281,1,"MTREX, EXOSC10, EXOSC5, EXOSC7, EXOSC9, EXOSC3, XRN1, EXOSC8, EXOSC1, PNPT1, EXOSC6, LSM1, CNOT4, CNOT6L, EXOSC2, LSM2, HSPD1, HSPA9, PAPOLA, PATL1, CNOT2",0.0856568428805592,0,FALSE
+"H1299","Input","KEGG_RNA_POLYMERASE",0.19896,0.638,0.915,3472,1,"POLR1E, POLR2B, POLR2K, POLR2A, POLR2G, POLR2E, POLR2I, POLR2J, POLR3G, POLR2C",0.0385789059335517,0,FALSE
+"H1299","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.31116,-0.981,0.435,6936,0.61,"PAPSS1, GGT7, SEPHS1, AHCYL1, SCLY, MAT1A, GGT1, CTH",0.361510743045363,0.214670164989233,FALSE
+"H1299","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.39391,-1.25,0.179,8251,0.345,"PIK3CD, SKP2, ITGAV, CCND1, LAMA3, LAMA4, LAMA1, PTGS2, NFKBIA, LAMA5, FHIT, LAMB1, COL4A1, RXRG, TRAF4, FN1, RXRA, TP53, COL4A2",0.747146969020107,0.462180904926726,FALSE
+"H1299","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.1493,-0.476,1,9227,0.997,"VAMP8",0,0.00130484168834428,FALSE
+"H1299","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33909,1.06,0.344,970,0.856,"UGCG, UGT8, SMPD2, SGPP1, GALC, KDSR, PLPP2",0.46344155742847,0.0675262353228468,FALSE
+"H1299","Input","KEGG_SPLICEOSOME",0.53244,1.72,0.0484,3386,0.524,"DHX16, ALYREF, DHX38, BUD31, PRPF8, HNRNPA1, SNRPA, CDC5L, DDX23, PRPF6, RBM25, EFTUD2, SNRNP200, PRPF3, SNRPD3, CDC40, USP39, CTNNBL1, HNRNPU, SRSF9, PRPF31, PLRG1, AQR, SNRPE, MAGOHB, WBP11, SF3B4, BCAS2, NCBP1, SNRNP40, TXNL4A, U2AF2, SART1, RBM22, SF3B1, PPIL1, DDX39B, PUF60, HSPA1A, SNW1, DDX5, SNRPB, PRPF38A, RBMX, SYF2, XAB2, PQBP1, EIF4A3, CHERP, U2AF1, SLU7, HSPA8, SRSF6, TCERG1, NCBP2, TRA2B, TRA2A, SNRPB2, PRPF19, SNRPD1, SNRPD2, PRPF40A, SRSF5, HNRNPC, SNRPC, SNU13, SF3A3, SNRPG, SNRPA1, LSM2, SF3B6, HSPA6, SNRPF, SF3A1, PHF5A, SRSF1, PRPF4, CWC15, HNRNPM, SRSF4, U2SURP, DDX46, SF3A2, SMNDC1, CRNKL1",1.31515463835559,0.280668713016273,FALSE
+"H1299","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.55258,-1.71,0.0423,5917,0.136,"SI, GBE1, UGP2, AGL, GUSB, HK2, HK3, PYGB, PGM2L1, GANC, PYGL, UGDH, ENPP1, HK1, PGM1, UXS1, GYS1, GAA",1.37365963262496,0.866461091629782,TRUE
+"H1299","Input","KEGG_STEROID_BIOSYNTHESIS",-0.62292,-1.95,0.00883,6846,0.103,"LSS, CEL, LIPA, FDFT1, EBP, HSD17B7, DHCR7, SC5D, DHCR24, SQLE, MSMO1",2.05403929642243,0.987162775294828,TRUE
+"H1299","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.7242,-2.29,0.00182,7022,0.0455,"HSD17B8, AKR1C3, HSD17B12, AKR1C1, AKR1C2, HSD17B7, CYP1B1, CYP7B1, CYP3A5, HSD17B2, HSD3B1, STS, HSD11B2, CYP21A2",2.73992861201493,1.34198860334289,TRUE
+"H1299","Input","KEGG_SULFUR_METABOLISM",-0.57833,-1.82,0.0201,6936,0.116,"PAPSS1, CHST11, BPNT1, CHST13, CHST12, SULT1A1, SULT1A3",1.69680394257951,0.935542010773082,TRUE
+"H1299","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.22562,0.722,0.817,2791,1,"ELANE, CD40, SNRPD3, SNRPB, ACTN4, ACTN1, SNRPD1, C2",0.0877779434675845,0,FALSE
+"H1299","Input","KEGG_TASTE_TRANSDUCTION",-0.58189,-1.85,0.0207,6807,0.112,"GNAS, GNB1, PRKACB, GNB3, CACNA1A",1.68402965454308,0.950781977329818,TRUE
+"H1299","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.47691,-1.5,0.0826,7560,0.23,"MVK, HMGCR, HMGCS2, GGPS1, HMGCS1",1.08301995267962,0.638272163982407,FALSE
+"H1299","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.23701,0.78,0.752,1541,1,"TGFB1, SMURF1, SMURF2, THBS3, ZFYVE9, PPP2R1B, ACVR1, MYC",0.123782159408358,0,FALSE
+"H1299","Input","KEGG_THYROID_CANCER",-0.59161,-1.9,0.0177,7024,0.102,"RXRB, PAX8, HRAS, CCDC6, TCF7L2, TCF7L1, CCND1, NCOA4, LEF1, CTNNB1, RXRG, RXRA, TP53, CDH1",1.75202673363819,0.991399828238082,TRUE
+"H1299","Input","KEGG_TIGHT_JUNCTION",-0.47267,-1.47,0.0991,7888,0.243,"SRC, CDK4, TJP3, AMOTL1, MAP3K20, EXOC4, PPP2R2A, PATJ, MYL9, PRKCH, PARD6G, F11R, ACTG1, PPP2R2B, PARD6B, TJP2, MYH14, MYH7B, PRKCD, CTNNB1, SPTAN1, EPB41, LLGL2, EPB41L3, CLDN3, CTNNA1, CLDN4, CTNNA2, CLDN6, PRKCQ, EPB41L1, CLDN7, CRB3",1.00392634551472,0.614393726401688,FALSE
+"H1299","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.24179,-0.776,0.755,8511,0.881,"TOLLIP, NFKBIA, IL6, MAPK13, MAP2K6, MYD88",0.122053048370812,0.0550240915879521,FALSE
+"H1299","Input","KEGG_TRYPTOPHAN_METABOLISM",-0.528,-1.66,0.0461,7164,0.156,"ALDH9A1, KYNU, EHHADH, MAOA, ALDH3A2, GCDH, CYP1B1, DDC, ALDH2, MAOB, ALDH1B1",1.33629907461035,0.806875401645538,TRUE
+"H1299","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.43264,-1.36,0.127,5981,0.301,"IKBKB, PIK3R2, HK2, PIK3R3, HK3, MAPK3, PDX1, MAPK8, ABCC8, HK1, PIK3CD, INSR, IRS2, PRKCD, CACNA1A",0.896196279044043,0.521433504406157,FALSE
+"H1299","Input","KEGG_TYROSINE_METABOLISM",-0.46463,-1.45,0.114,8463,0.255,"DDC, DCT, HGD, ALDH3A1, TYRP1, MAOB, ALDH1A3, GSTZ1",0.943095148663527,0.593459819566045,FALSE
+"H1299","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.1836,-0.595,0.969,7371,0.992,"NCK2, PDPK1, VAV2, CBLB, GSK3B, CDK4, DLG1, PIK3CD, LCK, PTPN6, NFKBIA, MAPK13, PRKCQ",0.0136762229492347,0.00348832784582135,FALSE
+"H1299","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.29335,0.949,0.474,1847,1,"FBXO2, UBE2W, SMURF1, FBXW7, TRIP12, UBE4B, CDC34, NEDD4, CUL7, ANAPC4, BIRC2, SMURF2, CBL, HERC4, ANAPC5, UBE2B, BIRC6, UBE2K, CDC20, FANCL, CDC16, UBE2G1, CDC27, TRAF6, FBXO4, ANAPC1, CUL3, HERC2",0.324221658325915,0,FALSE
+"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.3668,1.16,0.245,3335,0.949,"BCAT1, VARS2, PDHA1",0.610833915635468,0.0227337875727074,FALSE
+"H1299","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.54959,-1.75,0.0193,7850,0.142,"DBT, HIBCH, ALDH3A2, AUH, PCCA, HMGCS2, ALDH6A1, ACAA1, HMGCS1, ACADS, PCCB, ALDH2, ABAT, ALDH1B1, HIBADH, MCEE",1.71444269099223,0.847711655616944,TRUE
+"H1299","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.3999,-1.26,0.165,7247,0.344,"ADCY9, GUCY1A1, MYH11, GNA11, MYL6B, GNAQ, GNA13, MYL6, ARHGEF11, PRKACB, MYL9, PLA2G12A, PRKCH, MYLK, PRKCD, ADCY5, PLCB1, PLA2G4A, PRKCQ",0.782516055786094,0.46344155742847,FALSE
+"H1299","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.23715,-0.737,0.77,6807,0.917,"GNAS, AVP, DCTN6, CREB5, ADCY9, CREB1, RAB5C, PRKACB, DYNLL2, ARHGDIB, CREB3L2",0.113509274827518,0.0376306643299789,FALSE
+"H1299","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.247,-0.775,0.754,8251,0.874,"PIK3CD, PLA2G12A, PTGS2, PLA2G4A, MAPK13, RAC2",0.122628654130226,0.058488567365597,FALSE
+"H1299","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.44029,-1.37,0.135,6334,0.296,"ATP6V0A1, ATP6V1G1, ATP6V0C, ATP6AP1, PLCG2, ATP6V1E1, GNAS, TJP1, ATP6V1F, ADCY9, ATP6V1C2, KDELR3, SLC12A2, PRKACB, ATP6V0D1, ATP6V0D2, PDIA4, ACTG1, TJP2, KDELR1",0.869666231504994,0.528708288941061,FALSE
+"H1299","Input","KEGG_VIRAL_MYOCARDITIS",-0.37315,-1.17,0.234,8387,0.398,"ITGB2, CCND1, ACTG1, CD55, MYH14, MYH7B, SGCD, RAC2",0.630784142589857,0.400116927926312,FALSE
+"H1299","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.29815,-0.942,0.457,7299,0.64,"RAC1, CTBP2, CSNK1E, TBL1XR1, TCF7L2, SFRP1, FZD7, PRKACB, DKK1, GSK3B, CREBBP, APC, TCF7L1, TBL1X, EP300, PPP2R5A, CCND1, LEF1, DAAM2, NKD2, WNT16, CTNNB1, PLCB1, DAAM1, TP53, RAC2, WNT11",0.34008379993015,0.193820026016113,FALSE
+"H1703","Input","KEGG_ABC_TRANSPORTERS",-0.4043,-1.19,0.24,7682,0.564,"ABCD4, ABCD3, ABCC3, ABCG2, ABCA2, ABCB6, ABCA1",0.619788758288394,0.248720896016658,FALSE
+"H1703","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.27251,-0.806,0.691,6970,0.934,"PML, MYC, PIK3CA, TCF7L2, PIM1, PIK3CB, HRAS, PIK3R1, PIK3R2, PIK3CD, CCND1, RUNX1",0.160521952625802,0.0296531237699066,FALSE
+"H1703","Input","KEGG_ADHERENS_JUNCTION",-0.28153,-0.852,0.631,7033,0.904,"PTPN6, RAC3, MET, TCF7L2, BAIAP2, CTNNA2, TGFBR1, CTNNA1, PTPRF, PTPN1, SNAI2, CTNNB1, ACTN4, CTNND1, IGF1R, RAC2, WAS",0.199970640755866,0.0438315695246367,FALSE
+"H1703","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",0.23757,0.735,0.817,2487,0.985,"STAT3, ACACB, NFKBIE, MAPK9, TNFRSF1A, MAPK10, IKBKG, CPT1A, NFKBIB, CPT1C, RELA, PRKAB2, MAPK8, CAMKK2, TRAF2, AKT1, TRADD, STK11, PRKAB1, NFKB1, PRKAG2",0.0877779434675845,0.00656376950238827,FALSE
+"H1703","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.36686,1.12,0.277,1463,0.883,"GLUL, ASNS, GLUD2, NIT2, ADSL, ASL, CAD, GOT1",0.557520230935551,0.0540392964224314,FALSE
+"H1703","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.50319,-1.45,0.0997,6972,0.446,"HSD11B2, PIK3CA, IRS2, PIK3CB, PDPK1, SFN, ATP1A2, PIK3R1, IRS1, PIK3R2, SLC9A3R2, PIK3CD",1.00130484168834,0.350665141287858,FALSE
+"H1703","Input","KEGG_ALZHEIMERS_DISEASE",0.28813,0.897,0.554,3141,0.979,"GRIN1, ATP2A3, GAPDH, COX6A1, PSEN2, COX6C, TNFRSF1A, PLCB2, NDUFA4, CASP7, CAPN1, COX7C, ITPR2, PLCB3, NDUFA8, COX7A2, CASP9, SDHA, MAPT, SDHB, BID, ATP5F1B, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, IDE, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, ATP5PD, UQCRQ, UQCRC1, CASP3, NDUFA7, CDK5, UQCRH, CALML3, NDUFC1, BAD, NDUFB5, NDUFS5, CYCS, NDUFA2, SDHD, CALM2, BACE2, NDUFB1, GNAQ, NDUFC2, CASP8, COX5A, NDUFB10, NDUFS7, PSEN1, UQCRC2, ATP5PB, NDUFS8, NDUFV3",0.25649023527157,0.00921730819686218,FALSE
+"H1703","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.22961,-0.683,0.885,7187,0.983,"NARS2, EARS2, PARS2, CARS2, MARS2",0.0530567293021746,0.00744648216786438,FALSE
+"H1703","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",0.23201,0.711,0.781,2568,0.979,"AMDHD2, UAP1, NANS, PGM1, FPGT, PMM1, GALK1, GNPDA2, HEXB, GNPDA1, GPI, CMAS, GNE, PGM3",0.1073489661227,0.00921730819686218,FALSE
+"H1703","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.24648,-0.737,0.816,9109,0.938,"GPX1, CASP1, TOMM40L",0.0883098412461389,0.0277971616209356,FALSE
+"H1703","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.4093,1.26,0.193,1493,0.742,"TAPBP, TAP1, CTSL, HSPA4, RFXAP, B2M, TAP2, RFXANK, IFI30, RFX5, HSP90AB1",0.714442690992226,0.129596094720973,FALSE
+"H1703","Input","KEGG_APOPTOSIS",0.23804,0.716,0.83,1398,1,"DFFA, RIPK1, PRKAR2B, TNFRSF1A, IL1A, ATM, XIAP, AIFM1, CASP7, IKBKG, CAPN1, MYD88, DFFB, CASP9, RELA, BID",0.0809219076239261,0,FALSE
+"H1703","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.68528,-2.05,0.00671,8675,0.105,"GGT5, PTGES, EPHX2, GPX6, GPX7, GPX1, PTGS2",2.17327747983101,0.978810700930062,TRUE
+"H1703","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.40013,-1.18,0.216,7871,0.535,"ALDH18A1, CKMT1A, SAT1, P4HA1, CKMT2, GLS, GLS2, P4HA2, ASS1, PRODH, PRODH2, CPS1, MAOA, AGMAT, ARG2, ARG1, LAP3",0.665546248849069,0.271646217978772,FALSE
+"H1703","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.61267,-1.82,0.0214,7584,0.23,"CTNNA2, ITGA11, DSG2, ITGA6, CTNNA1, ATP2A2, ITGA1, ITGA4, DSC2, ITGB6, ITGB4, ITGA7, CTNNB1, ACTN4, ITGB3, SLC8A1, GJA1, ITGA2, ITGB8",1.66958622665081,0.638272163982407,TRUE
+"H1703","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.52978,1.63,0.0682,110,0.539,"ALDH3A2",1.16621562534352,0.268411234813261,FALSE
+"H1703","Input","KEGG_AXON_GUIDANCE",-0.3431,-1.03,0.397,6981,0.666,"RGS3, PTK2, RAC3, GNAI3, PPP3R1, EPHA6, MET, PAK4, ARHGEF12, PPP3CA, EFNA1, PPP3CC, DPYSL5, GNAI1, HRAS, EPHA1, NRP1, EPHA4, SEMA4G, NTN4, PLXNA2, EPHA7, EFNB2, ABLIM1, ABLIM3, EPHB2, SEMA7A, RAC2, NFATC4, CXCR4",0.401209493236885,0.176525770829699,FALSE
+"H1703","Input","KEGG_BASAL_CELL_CARCINOMA",0.32135,0.989,0.401,870,0.898,"GLI3, DVL2, FZD2",0.396855627379818,0.0467236633326956,FALSE
+"H1703","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",-0.19091,-0.57,0.989,6148,1,"TAF4, TAF5L, GTF2E1, TAF5, GTF2A1, TAF1, GTF2H4, GTF2I, GTF2H2, GTF2H3, GTF2H1",0.0048037084028206,0,FALSE
+"H1703","Input","KEGG_BASE_EXCISION_REPAIR",0.26895,0.823,0.668,2966,0.961,"MUTYH, PARP4, POLD4, HMGB1, NEIL2, PCNA, APEX1, POLL, POLE, POLD2, NTHL1",0.175223537524454,0.0172766123314547,FALSE
+"H1703","Input","KEGG_BETA_ALANINE_METABOLISM",0.33325,0.994,0.414,993,0.944,"ALDH3A2, SMS",0.382999658879101,0.025028005701931,FALSE
+"H1703","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.30453,-0.895,0.574,7063,0.83,"ACOT2, ACOX3, ACOX1, TECR, HSD17B12, FADS2, ELOVL6",0.241088107602027,0.0809219076239261,FALSE
+"H1703","Input","KEGG_BLADDER_CANCER",-0.47013,-1.37,0.139,7425,0.524,"DAPK1, CDK4, VEGFC, HRAS, TYMP, THBS1, VEGFA, MMP2, CCND1, CDKN1A",0.856985199745905,0.280668713016273,FALSE
+"H1703","Input","KEGG_BUTANOATE_METABOLISM",-0.43968,-1.32,0.146,7866,0.519,"HMGCS1, BDH2, ABAT, ACSM3, BDH1, HMGCS2, ACADS",0.835647144215563,0.284832642151542,FALSE
+"H1703","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.35552,-1.05,0.371,7033,0.657,"PTPN6, RAC3, PPP3R1, PIK3CA, LYN, PPP3CA, PPP3CC, PIK3CB, VAV3, HRAS, PIK3R1, SYK, PIK3R2, PIK3AP1, CD81, PIK3CD, INPP5D, RAC2, NFATC4",0.430626090384954,0.182434630440219,FALSE
+"H1703","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.2345,0.715,0.838,1722,0.989,"PDGFRA, GRIN1, ATP2A3, RYR1, PLCB2, ITPR2, PLCB3, PLCG2, PLCD1, TACR1, NOS3, PHKA1, PHKB, PRKACA, PRKCA, PPID",0.0767559813697235,0.0048037084028206,FALSE
+"H1703","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.3647,1.11,0.306,2335,0.833,"CACNA2D1, TPM2, COX6A1, COX6C, COX7C, TPM3, COX7A2, TPM1, UQCRB, COX5B, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, UQCRQ, UQCRC1, UQCRH",0.51427857351842,0.0793549985932124,FALSE
+"H1703","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.4641,-1.41,0.1,7987,0.492,"PTPRC, PTPRF, CNTN1, ITGA4, NRCAM, ICAM1, CLDN7, ICAM2, SDC1, PDCD1LG2, CLDN3, SDC2, CADM1, SDC4, NCAM1, VCAN, CD274, PECAM1, F11R, ITGB8",1,0.30803489723264,FALSE
+"H1703","Input","KEGG_CELL_CYCLE",-0.14348,-0.426,0.998,7005,1,"TP53, BUB1B, ORC6, MYC, CCND3, CDK7, CCNB2, SKP2, CDK4, TGFB3, CDC7, SFN, BUB1, RBL1, WEE1, CDC6, TGFB2, CCND1, CDKN1A",0.000869458712628891,0,FALSE
+"H1703","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.3855,-1.12,0.3,7014,0.612,"CCL13, RAP1B, PTK2, GNAI3, CCL20, PLCB4, PIK3CA, GNG5, CXCL6, JAK3, ARRB1, GNB1, LYN, PRKCD, RAP1A, GNB3, PIK3CB, GNAI1, STAT2, VAV3, HRAS, ADCY9, PIK3R1, GNG2, PIK3R2, PTK2B, PIK3CD, RAC2, CXCR4, WAS, CXCL1",0.522878745280338,0.213248577854439,FALSE
+"H1703","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.35831,-1.08,0.317,7539,0.631,"CDK4, PIK3CB, TGFB3, TGFBR1, BCL2L1, HRAS, PIK3R1, CBLB, PIK3R2, PIK3CD, MECOM, TGFB2, GAB2, CCND1, RUNX1, CDKN1A",0.498940737782249,0.199970640755866,FALSE
+"H1703","Input","KEGG_CIRCADIAN_RHYTHM_MAMMAL",-0.35652,-1.06,0.361,6420,0.66,"CSNK1D, CLOCK, BHLHE41, BHLHE40, CSNK1E",0.442492798094342,0.180456064458131,FALSE
+"H1703","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",-0.13956,-0.413,1,1286,1,"ACO2, SDHA, SDHB, MDH1, ACLY, DLD, SDHD, FH, PCK2, PDHB, IDH3A, PDHA1, ACO1, SDHC, IDH3G, SUCLG2, SUCLG1, OGDH, OGDHL, MDH2, IDH1, DLAT, SUCLA2, IDH3B, IDH2, DLST, CS, PC, PCK1",0,0,FALSE
+"H1703","Input","KEGG_COLORECTAL_CANCER",-0.25572,-0.763,0.763,7005,0.922,"TP53, RAC3, MYC, PIK3CA, TCF7L2, PIK3CB, TGFB3, TGFBR1, APC, PIK3R1, CTNNB1, PIK3R2, PIK3CD, TGFB2, RAC2, CCND1",0.11747546204512,0.0352690789463706,FALSE
+"H1703","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.37835,-1.1,0.317,7762,0.626,"PROC, PLAT, C9, F5, PLAUR, C3, THBD, PLAU, SERPINA1, CD59, SERPINC1, CD55, MBL2",0.498940737782249,0.20342566678957,FALSE
+"H1703","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.27725,0.867,0.588,1617,0.963,"LDHB, MTAP, CDO1, SMS, MPST, GOT1, MAT2B, AHCY",0.230622673923862,0.0163737128754655,FALSE
+"H1703","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.32933,-0.965,0.464,8580,0.714,"EPO, IL6, VEGFA, IL1RAP, ACVR1B, TGFB2, TNFRSF12A, IL1R1, CXCR4, CXCL1, LTBR",0.333482019445119,0.146301788223826,FALSE
+"H1703","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.33329,-0.979,0.426,7330,0.707,"ADAR, POLR3D, POLR3H, POLR3A, POLR3K, POLR3B, IL6, PYCARD, TREX1, CASP1",0.370590400897281,0.150580586203101,FALSE
+"H1703","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.53769,-1.57,0.0637,7673,0.356,"TGFB3, ITGA11, TTN, GNAS, ITGA6, ATP2A2, ITGA1, ITGA4, ADCY9, ITGB6, ITGB4, ITGA7, TNNC1, ITGB3, SLC8A1, TGFB2, ITGA2, ITGB8",1.19586056766465,0.448550002027125,FALSE
+"H1703","Input","KEGG_DNA_REPLICATION",0.36361,1.14,0.29,4066,0.914,"RNASEH2C, RPA3, POLD4, MCM5, RFC4, POLA2, POLA1, MCM3, PCNA, POLE, POLD2, PRIM2, MCM7, MCM4, RFC2, MCM6, RFC5, RNASEH2B, RNASEH2A, PRIM1, LIG1, POLD3, MCM2, RPA2",0.537602002101044,0.0390538042661686,FALSE
+"H1703","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.55424,1.75,0.0326,2068,0.614,"ETS1, NOTCH3, SPIRE1, SPIRE2, EGFR, NOTCH2",1.48678239993206,0.211831628858832,FALSE
+"H1703","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",-0.50548,-1.52,0.066,8388,0.382,"ALDH3A1, GSTM4, GSTM1, MAOA, GSTT2, GSTM2, MGST1",1.18045606445813,0.417936637088291,FALSE
+"H1703","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.2743,-0.82,0.667,8059,0.928,"NAT2, TYMP, CES1, CES2, CDA",0.175874166083451,0.0324520237811379,FALSE
+"H1703","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.7124,-2.11,0.00676,8151,0.119,"HSPG2, ITGA1, ITGA4, COL6A3, COL1A2, ITGB6, ITGB4, VTN, COL11A1, LAMB3, ITGA7, LAMC2, LAMA3, LAMA4, SDC1, FN1, THBS1, COL5A1, CD36, TNC, SDC2, COL6A1, LAMB1, ITGB3, COL3A1, SDC4, AGRN, ITGA2, CD44, ITGB8",2.17005330405836,0.924453038607469,TRUE
+"H1703","Input","KEGG_ENDOCYTOSIS",0.16136,0.491,1,676,1,"PDGFRA, PLD2, DNM1L, IQSEC1, EPN2, RAB11FIP3, VPS4B, RUFY1, RABEP1, STAM2",0,0,FALSE
+"H1703","Input","KEGG_ENDOMETRIAL_CANCER",-0.40798,-1.23,0.198,7005,0.573,"TP53, MYC, PIK3CA, TCF7L2, CTNNA2, PIK3CB, PDPK1, ILK, APC, CTNNA1, HRAS, PIK3R1, CTNNB1, PIK3R2, PIK3CD, CCND1",0.703334809738469,0.24184537803261,FALSE
+"H1703","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.26972,-0.788,0.721,6469,0.926,"TJP1, JUN, ATP6V1A, ATP6V1C2, ATP6V0A2, ATP6V0C, ATP6V1B2, ATP6V0D1, ATP6V1G2, MET, TCIRG1, ATP6V1D, ATP6V1B1, LYN, ATP6V1H, JAM2, ADAM10, MAPK13, F11R, CXCL1",0.142064735280571,0.0333890133180656,FALSE
+"H1703","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.18882,-0.559,0.988,7051,0.997,"PTK2, MYC, PIK3CA, PAK4, TGFA, CAMK2D, PIK3CB, MAP2K7, HRAS, PIK3R1, CBLB, PIK3R2, PIK3CD, ERBB3, CDKN1A",0.00524305541237188,0.00130484168834428,FALSE
+"H1703","Input","KEGG_ETHER_LIPID_METABOLISM",-0.26861,-0.794,0.74,7594,0.925,"PAFAH2, PLA2G4A, LPCAT2, PLPP3, CHPT1",0.130768280269024,0.0338582672609674,FALSE
+"H1703","Input","KEGG_FATTY_ACID_METABOLISM",0.28387,0.864,0.588,1424,0.949,"ALDH3A2, ACAA2, ECI1, ACAT1, CPT1A, ADH5, CPT1C, ECI2",0.230622673923862,0.0227337875727074,FALSE
+"H1703","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.44762,-1.33,0.158,7041,0.518,"PLA2G12A, RAC3, PIK3CA, LYN, PRKCD, PIK3CB, MAP2K7, PDPK1, PLA2G4A, VAV3, HRAS, PIK3R1, MAPK13, LCP2, SYK, PIK3R2, PIK3CD, INPP5D, RAC2, GAB2",0.801342913045577,0.285670240254767,FALSE
+"H1703","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.39254,-1.18,0.214,7878,0.535,"PLA2G4A, AMPH, VAV3, PTPRC, PIP5K1C, PIK3R1, PLA2G4F, MYO10, ASAP2, SYK, ARPC1A, MARCKS, PLPP3, PIK3R2, SCIN, PIK3CD, INPP5D, RAC2, GAB2, WAS",0.669586226650809,0.271646217978772,FALSE
+"H1703","Input","KEGG_FOCAL_ADHESION",-0.39802,-1.22,0.211,8188,0.549,"PIP5K1C, ITGA1, ITGA4, PIK3R1, COL6A3, PDGFRB, COL1A2, ITGB6, ITGB4, VTN, COL11A1, LAMB3, FLNC, ITGA7, LAMC2, CTNNB1, PIK3R2, LAMA3, LAMA4, PARVA, ACTN4, FN1, THBS1, COL5A1, VEGFA, TNC, COL6A1, LAMB1, ITGB3, PIK3CD, COL3A1, IGF1R, RAC2, ITGA2, CCND1, FLNB, ITGB8",0.675717544702307,0.260427655549908,FALSE
+"H1703","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.62193,-1.84,0.0231,8632,0.232,"QDPR, PTS",1.63638802010786,0.6345120151091,TRUE
+"H1703","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",0.2272,0.699,0.881,1679,0.966,"TPI1, PHPT1, AKR1B1, FPGT, PMM1, MTMR6, PFKFB3",0.0550240915879521,0.0150228735845067,FALSE
+"H1703","Input","KEGG_GALACTOSE_METABOLISM",-0.22831,-0.671,0.886,6436,0.969,"GALE, GAA, PGM2, HK3, PFKM, MGAM, B4GALT1",0.0525662781129492,0.0136762229492347,FALSE
+"H1703","Input","KEGG_GAP_JUNCTION",0.366,1.11,0.284,1351,0.833,"PDGFRA, MAPK7, TUBB2B, PDGFC, TUBA3C, TUBB6, PLCB2, TUBA1C, TUBB1, TUBB3, ITPR2, PLCB3, TUBB, TUBB2A, RAF1",0.546681659952962,0.0793549985932124,FALSE
+"H1703","Input","KEGG_GLIOMA",-0.25689,-0.763,0.763,8076,0.922,"HRAS, PIK3R1, PDGFRB, PIK3R2, PIK3CD, IGF1R, CCND1, CDKN1A",0.11747546204512,0.0352690789463706,FALSE
+"H1703","Input","KEGG_GLUTATHIONE_METABOLISM",-0.54723,-1.6,0.0688,8605,0.354,"GSTM4, GGT5, GSTM1, ANPEP, GPX6, GPX7, GPX1, GSTT2, GSTM2, LAP3, MGST1",1.16241156176449,0.450996737974212,FALSE
+"H1703","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.51616,-1.51,0.0771,8591,0.377,"PLPP3, DGAT1, LPL, DGKA, DGKB, LIPG, MGLL",1.11294562194904,0.423658649794207,FALSE
+"H1703","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.21067,-0.627,0.944,7873,0.99,"GPD1, PLA2G4A, GPD2, LPCAT2, PLPP3, DGKA, CHPT1, DGKB",0.025028005701931,0.00436480540245009,FALSE
+"H1703","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.3134,0.98,0.421,1040,0.867,"SRR, PSAT1, GAMT, MAOB, PIPOX, PHGDH",0.375717904164332,0.0619809025237897,FALSE
+"H1703","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",0.26521,0.822,0.656,1399,0.943,"ALDH3A2, LDHB, TPI1, GAPDH, ENO1, ENO3, PGAM1, PGAM4, ADH5, PGK1, PGM1",0.18309616062434,0.0254883072626717,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.39567,-1.18,0.224,6744,0.535,"XYLT2, CHST12, B4GALT7, CHPF2, B3GAT3, CHSY1, CHST11, CHPF, CHST14",0.649751981665837,0.271646217978772,FALSE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.70026,-2.07,0.00828,6744,0.108,"XYLT2, B4GALT7, HS2ST1, B3GAT3, GLCE, EXT1, EXTL2, EXTL3, EXT2",2.08196966321512,0.96657624451305,TRUE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.73339,-2.14,0.00165,7501,0.123,"B3GNT2, B4GAT1, B4GALT3, B4GALT4, ST3GAL2, FUT8, B4GALT1",2.78251605578609,0.910094888560602,TRUE
+"H1703","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.26112,0.803,0.693,3244,0.949,"HYAL2, HEXB, IDUA, GNS, ARSB, HEXA, HYAL1, GALNS",0.159266765388193,0.0227337875727074,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.47906,1.45,0.111,124,0.753,"B4GALNT1",0.954677021213343,0.123205023799299,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.4598,-1.35,0.136,8348,0.537,"ST3GAL2, B3GALNT1",0.866461091629782,0.270025714300444,FALSE
+"H1703","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.78145,-2.31,0.00166,7501,0.168,"B3GNT2, B4GAT1, B3GNT3, ST3GAL4, B4GALT3, B4GALT4, B4GALT1",2.77989191195995,0.774690718274137,TRUE
+"H1703","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.22373,-0.675,0.882,5264,0.974,"PIGS, PIGM, GPAA1, PIGT, PIGK, PIGO, PGAP1",0.0545314148681803,0.0114410431213845,FALSE
+"H1703","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.25732,0.791,0.724,1897,0.94,"PGP, MTHFD1L, ACO2, MDH1",0.140261433802853,0.0268721464003014,FALSE
+"H1703","Input","KEGG_GNRH_SIGNALING_PATHWAY",0.21049,0.659,0.9,1668,0.991,"MAPK7, PLD2, ATF4, MAPK9, MAP2K4, PLCB2, MAPK10, ITPR2, PLCB3, RAF1, MAPK8, PRKACA, PRKCA",0.0457574905606751,0.00392634551472468,FALSE
+"H1703","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",0.30363,0.915,0.515,1869,0.96,"GLI3, BTRC, PRKACA, FBXW11",0.288192770958809,0.0177287669604316,FALSE
+"H1703","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.72282,-2.14,0.00345,7834,0.123,"ITGA6, MME, CD38, ITGA1, ITGA4, EPO, IL6, CD59, CD55, CD36, ITGB3, ANPEP, ITGA2, IL1R1, CD44",2.46218090492673,0.910094888560602,TRUE
+"H1703","Input","KEGG_HISTIDINE_METABOLISM",-0.40597,-1.21,0.204,7974,0.554,"ALDH1A3, ALDH3A1, MAOA, HNMT",0.690369832574101,0.25649023527157,FALSE
+"H1703","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.42897,1.29,0.157,3182,0.716,"SEM1, BLM, RPA3, POLD4, MRE11, RAD50, EME1, POLD2, NBN, RAD54L, XRCC3",0.804100347590766,0.145086977692144,FALSE
+"H1703","Input","KEGG_HUNTINGTONS_DISEASE",0.37406,1.14,0.28,3261,0.914,"GRIN1, COX6A1, DNAH3, SOD1, COX6C, PLCB2, HIP1, NDUFA4, COX7C, PLCB3, TBPL1, DCTN4, NDUFA8, COX7A2, CASP9, SDHA, SDHB, CLTA, ATP5F1B, DCTN2, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, PPID, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, TBP, CLTB, CREB3L1, ATP5PD, IFT57, CLTC, UQCRQ, REST, UQCRC1, DCTN1, CASP3, NDUFA7, TFAM, UQCRH, BAX, NDUFC1, DNAL1, NDUFB5, POLR2H, NDUFS5, HAP1, CYCS, NDUFA2, SDHD, VDAC1, SP1, DNAL4, NDUFB1, GNAQ, NDUFC2, CASP8, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3, ATP5F1D, HTT, COX7B",0.552841968657781,0.0390538042661686,FALSE
+"H1703","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.5246,-1.56,0.0849,7673,0.35,"TGFB3, ITGA11, TTN, ITGA6, ATP2A2, ITGA1, ITGA4, ITGB6, ITGB4, ACE, ITGA7, IL6, TNNC1, ITGB3, SLC8A1, TGFB2, ITGA2, ITGB8",1.07109230975605,0.455931955649724,FALSE
+"H1703","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",0.28927,0.879,0.597,1591,1,"ISYNA1, TPI1, IMPA1, OCRL, INPP4B, PLCB2, PLCB3, PLCG2, PLCD1, INPP5K, PIK3C3, PTEN",0.224025668870631,0,FALSE
+"H1703","Input","KEGG_INSULIN_SIGNALING_PATHWAY",0.25191,0.768,0.753,1865,0.952,"EIF4EBP1, CRK, ACACB, SHC1, ACACA, FLOT2, TRIP10, RPS6KB1, FLOT1, PYGL, MKNK1, MAPK9, PRKAR2B, MAPK10, RAF1, PHKA1, INPP5K, CRKL, PHKB, PRKAB2, MAPK8, FOXO1, PRKACA, SREBF1, SORBS1, INSR, RPTOR",0.123205023799299,0.0213630516155257,FALSE
+"H1703","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.58073,-1.72,0.0333,8276,0.292,"ITGA4, IL6, CXCR4, LTBR",1.47755576649368,0.534617148551582,FALSE
+"H1703","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.42412,-1.24,0.188,7033,0.585,"PTPN6, MYC, PIK3CA, JAK3, CCND3, STAT6, JAK1, PIM1, LEPR, PIK3CB, IL13RA2, STAT2, SPRY1, BCL2L1, PIK3R1, CBLB, EPO, IL6, PIK3R2, PIK3CD, CCND1, SPRY2",0.72584215073632,0.23284413391782,FALSE
+"H1703","Input","KEGG_LEISHMANIA_INFECTION",-0.40624,-1.19,0.236,8254,0.564,"C3, ITGA4, TRAF6, MAPK13, CYBA, TGFB2, PTGS2",0.627087997029893,0.248720896016658,FALSE
+"H1703","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.43134,-1.26,0.195,7584,0.598,"CTNNA2, PIK3CB, JAM2, GNAI1, VAV3, CTNNA1, ITGA4, PIK3R1, ICAM1, MAPK13, CLDN7, CTNNB1, PIK3R2, ACTN4, CLDN3, PTK2B, CYBA, PIK3CD, CTNND1, RAC2, PECAM1, MMP2, F11R, CXCR4",0.709965388637482,0.223298816011589,FALSE
+"H1703","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.56034,1.73,0.0447,110,0.529,"ALDH3A2",1.34969247686806,0.276544327964814,FALSE
+"H1703","Input","KEGG_LONG_TERM_DEPRESSION",-0.34395,-1.02,0.381,7041,0.654,"PLA2G12A, GNAI3, PLCB4, PPP2CB, GNA12, GUCY1A1, LYN, GNA11, GNAI1, GNAS, PLA2G4A, ITPR3, HRAS, PRKG1, IGF1R",0.419075024324381,0.184422251675733,FALSE
+"H1703","Input","KEGG_LONG_TERM_POTENTIATION",0.27941,0.873,0.613,2911,0.995,"GRIN1, ATF4, RPS6KA1, PLCB2, ITPR2, PLCB3, RAF1, PRKACA, PRKCA, RPS6KA2, CAMK2G, CALML3, MAP2K2, PRKCB, CALM2, RPS6KA3, GNAQ",0.212539525481585,0.00217691925427455,FALSE
+"H1703","Input","KEGG_LYSINE_DEGRADATION",-0.27807,-0.819,0.659,7276,0.918,"SUV39H1, DLST, NSD2, SUV39H2, DOT1L, SETD7, PLOD1, PLOD2, AASS",0.18111458540599,0.0371573187987575,FALSE
+"H1703","Input","KEGG_LYSOSOME",0.28238,0.852,0.614,1885,0.935,"MCOLN1, NAGA, SUMF1, GGA2, CTSK, CTSO, IGF2R, CTSL, LAMP3, SLC17A5, PSAPL1, CTSG, CLN5, ARSA, GLA, LAMP2, AP1S1, AP1S2, AP3M1, CLTA, AP3S1, AGA, NPC2, PSAP, GGA3, DNASE2, M6PR, AP1M1, AP3B1, AP3D1, HEXB",0.211831628858832,0.0291883891274822,FALSE
+"H1703","Input","KEGG_MAPK_SIGNALING_PATHWAY",0.26549,0.812,0.682,2486,0.948,"PDGFRA, MEF2C, TGFBR2, HSPB1, MAPK7, CACNA2D1, MAP3K20, CRK, RELB, NFKB2, ATF4, MKNK1, MAPK9, RPS6KA1, TNFRSF1A, IL1A, MAP2K4, MAPK10, TGFB1, STMN1, IKBKG, NF1, PPM1B, RAF1, RELA, MAPT, MAP3K7, CRKL, MAPK8, ARRB2, TAB2, PRKACA, PRKCA, RPS6KA2, TAB1, EGFR, PAK1, TRAF2, HSPA1A, TAOK1, AKT1, PAK2, MOS, MAPK12, FLNA, HSPA6, CASP3, MAP2K2, HSPA2, RRAS, RASA1, NFKB1, DUSP3",0.166215625343521,0.0231916626619338,FALSE
+"H1703","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.47615,-1.39,0.136,7844,0.508,"HNF1B, PDX1, HNF1A, HNF4A",0.866461091629782,0.294136287716081,FALSE
+"H1703","Input","KEGG_MELANOGENESIS",-0.21183,-0.625,0.95,6828,0.982,"CREBBP, GNAO1, DVL3, DVL1, GNAI3, PLCB4, WNT5A, TCF7L2, CAMK2D, GNAI1, GNAS, HRAS, MITF, ADCY9, CTNNB1",0.0222763947111523,0.00788851221305034,FALSE
+"H1703","Input","KEGG_MELANOMA",-0.30701,-0.922,0.509,8076,0.783,"HRAS, MITF, PIK3R1, PDGFRB, PIK3R2, PIK3CD, IGF1R, CCND1, CDKN1A",0.293282217663241,0.106238237942057,FALSE
+"H1703","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",-0.54709,-1.59,0.0528,7974,0.347,"ALDH1A3, AKR1C1, ALDH3A1, GSTM4, CYP2S1, GSTM1, GSTT2, GSTM2, MGST1",1.27736607746619,0.459670525209126,FALSE
+"H1703","Input","KEGG_MISMATCH_REPAIR",0.5492,1.71,0.0376,1950,0.475,"PMS2, MSH6, MLH1, MSH2, MSH3, RPA3, POLD4, RFC4",1.42481215507234,0.323306390375133,FALSE
+"H1703","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.23104,-0.677,0.9,7171,0.981,"PIK3CA, CAB39, RPS6, PIK3CB, PDPK1, VEGFC, PIK3R1, PIK3R2, VEGFA, PIK3CD",0.0457574905606751,0.0083309926200515,FALSE
+"H1703","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.37381,-1.11,0.295,7033,0.618,"PTPN6, RAC3, PPP3R1, ITGB2, PIK3CA, RAET1L, ULBP2, PPP3CA, PPP3CC, PIK3CB, TNFRSF10B, VAV3, HRAS, PIK3R1, ICAM1, LCP2, ICAM2, SYK, PIK3R2, PTK2B, PIK3CD, RAC2, NFATC4",0.530177984021837,0.209011524911184,FALSE
+"H1703","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",0.50978,1.58,0.0526,1974,0.56,"GRIN1, CTSG, NR3C1, TACR1, PLG, PRSS1, HRH1",1.27901425584626,0.2518119729938,FALSE
+"H1703","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",0.24435,0.754,0.769,2459,0.963,"NGFR, MAPK7, CRK, SHC1, ATF4, NFKBIE, YWHAH, MAPK9, RPS6KA1, MAPK10, FOXO3, YWHAE, NFKBIB, PLCG2, RAF1, RELA, CRKL, MAPK8, RPS6KA2, KIDINS220, YWHAG, AKT1, YWHAQ, CAMK2G, MAPK12, YWHAB, CALML3, BAX, MAP2K2, NFKB1, BAD",0.114073660198569,0.0163737128754655,FALSE
+"H1703","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.3463,-1.02,0.392,7317,0.654,"PNP, QPRT, NT5C3A, CD38, NT5E, NNT",0.406713932979543,0.184422251675733,FALSE
+"H1703","Input","KEGG_NITROGEN_METABOLISM",0.38064,1.17,0.262,308,0.926,"GLUL, CA13, ASNS, GLUD2",0.581698708680255,0.0333890133180656,FALSE
+"H1703","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.41018,-1.23,0.202,8387,0.573,"TRAF6, MAPK13, IL6, PYCARD, CASP1, TRIP6, CXCL1",0.694648630553376,0.24184537803261,FALSE
+"H1703","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",0.45191,1.36,0.126,2726,0.7,"MRE11, XRCC4, LIG4, RAD50, POLL",0.899629454882437,0.154901959985743,FALSE
+"H1703","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.27123,-0.803,0.72,7005,0.929,"TP53, PIK3CA, TGFA, CDK4, RXRA, PIK3CB, PDPK1, HRAS, PIK3R1, PIK3R2, PIK3CD, CCND1",0.142667503568732,0.0319842860063582,FALSE
+"H1703","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.26355,0.797,0.693,869,0.945,"NOTCH3, DVL2, NUMBL, PSEN2, MAML2",0.159266765388193,0.0245681914907371,FALSE
+"H1703","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.19425,-0.575,0.981,6228,1,"CCNH, MNAT1, RFC1, DDB2, XPC, GTF2H5, GTF2H4, CDK7, POLE4, ERCC2, ERCC3, GTF2H2, GTF2H3, ERCC5, GTF2H1",0.0083309926200515,0,FALSE
+"H1703","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",-0.45106,-1.33,0.135,5851,0.518,"MGAT1, ALG11, DAD1, DDOST, TUSC3, RPN2, ALG14, DPM3, ALG1, MGAT3, MGAT2, ALG9, MOGS, MAN2A1, MAN2A2, MAN1A1, MAN1A2, MAN1B1, B4GALT3, DOLPP1, FUT8, MGAT5, B4GALT1",0.869666231504994,0.285670240254767,FALSE
+"H1703","Input","KEGG_OLFACTORY_TRANSDUCTION",-0.23261,-0.701,0.859,6762,0.977,"PDC, CNGB1, CAMK2D, PRKG1",0.0660068361687577,0.0101054362812269,FALSE
+"H1703","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.36991,1.12,0.267,1729,0.883,"MTHFD1L, ATIC, GART, SHMT1",0.573488738635425,0.0540392964224314,FALSE
+"H1703","Input","KEGG_OOCYTE_MEIOSIS",0.17911,0.546,0.984,2435,1,"CDC25C, PTTG1, YWHAH, RPS6KA1, ITPR2, YWHAE, PPP2R5D, BTRC, ESPL1, CDC26, PRKACA, RPS6KA2, FBXW11, YWHAG, MOS, YWHAQ, CAMK2G, MAPK12, YWHAB, CDK1, CALML3, ANAPC4",0.00700490156865849,0,FALSE
+"H1703","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.31633,0.964,0.443,3060,0.859,"MAN2B2, AGA, HEXB, MAN2B1, HEXA",0.35359627377693,0.0660068361687577,FALSE
+"H1703","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.36588,1.1,0.285,3387,0.824,"COX6A1, COX6C, LHPP, COX11, NDUFA4, COX7C, NDUFA11, COX15, NDUFA8, COX7A2, SDHA, SDHB, ATP5F1B, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, CYC1, COX4I1, UQCRFS1, COX7A2L, COX6B1, ATP5PD, UQCRQ, UQCRC1, NDUFA7, UQCRH, NDUFC1, NDUFB5, NDUFS5, NDUFA2, SDHD, NDUFB1, NDUFC2, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3, PPA1, ATP5F1D, COX7B, ATP5PF, UQCR10, ATP5ME",0.54515513999149,0.0840727883028842,FALSE
+"H1703","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.73514,-2.2,0.00341,7562,0.163,"GALNT12, C1GALT1, B3GNT6, GALNT11, GALNT4, GALNT1, GALNT13, GALNT15, GALNT7, ST3GAL2, GALNT2, GCNT1, GALNT5, B4GALT5, GALNT3, GALNT6",2.4672456210075,0.787812395596042,TRUE
+"H1703","Input","KEGG_P53_SIGNALING_PATHWAY",-0.28371,-0.847,0.648,7461,0.891,"CCNB2, CDK4, PMAIP1, TNFRSF10B, SFN, RCHY1, IGFBP3, THBS1, SERPINB5, CCND1, CDKN1A",0.188424994129407,0.0501222959631252,FALSE
+"H1703","Input","KEGG_PANCREATIC_CANCER",-0.26446,-0.796,0.728,7005,0.932,"TP53, RAC3, RAD51, PIK3CA, TGFA, JAK1, CDK4, PIK3CB, TGFB3, TGFBR1, RALB, VEGFC, BCL2L1, PIK3R1, PIK3R2, VEGFA, PIK3CD, TGFB2, RAC2, CCND1",0.137868620686963,0.0305840876460186,FALSE
+"H1703","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.23482,-0.685,0.864,2169,0.99,"PPCS, PPCDC, PANK2, DPYD, COASY, PANK4, BCAT2",0.0634862575211067,0.00436480540245009,FALSE
+"H1703","Input","KEGG_PARKINSONS_DISEASE",0.4569,1.38,0.123,3141,0.778,"UCHL1, UBE2G1, SLC18A1, COX6A1, UBE2L6, COX6C, NDUFA4, COX7C, NDUFA8, COX7A2, CASP9, SDHA, SDHB, ATP5F1B, UBE2L3, NDUFS4, UQCRB, NDUFA3, COX5B, NDUFS6, PPID, CYC1, COX4I1, PARK7, UQCRFS1, COX7A2L, COX6B1, LRRK2, ATP5PD, UQCRQ, UQCRC1, CASP3, NDUFA7, UQCRH, NDUFC1, NDUFB5, NDUFS5, CYCS, NDUFA2, SDHD, VDAC1, NDUFB1, NDUFC2, COX5A, NDUFB10, NDUFS7, UQCRC2, ATP5PB, NDUFS8, NDUFV3",0.910094888560602,0.109020403010311,FALSE
+"H1703","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.33129,-0.99,0.431,8560,0.694,"ARPC1A, HCLS1, CTNNB1, TUBA4A, WAS",0.365522729839268,0.158640529545145,FALSE
+"H1703","Input","KEGG_PATHWAYS_IN_CANCER",-0.24668,-0.72,0.813,7516,0.956,"SKP2, TPR, CDK4, RXRA, CTNNA2, PIK3CB, TGFB3, TGFBR1, RALB, APC, PAX8, VEGFC, ITGA6, HSP90B1, CTNNA1, BCL2L1, HRAS, MITF, PIK3R1, PDGFRB, CBLB, TRAF6, LAMB3, LAMC2, IL6, CTNNB1, PIK3R2, LAMA3, LAMA4, FN1, VEGFA, LAMB1, PIK3CD, MECOM, TGFB2, IGF1R, RAC2, ITGA2, MMP2, CCND1, RUNX1, SLC2A1, CDKN1A, PTGS2",0.0899094544059319,0.0195421077238999,FALSE
+"H1703","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",0.3191,0.966,0.421,2088,0.878,"RPE, AKR1B1, CRYL1, XYLB",0.375717904164332,0.0565054840938974,FALSE
+"H1703","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",0.27783,0.86,0.585,1399,0.937,"PGLS, DERA, PRPS1, PRPS1L1, PGD, RPE, PGM1",0.23284413391782,0.0282604091122217,FALSE
+"H1703","Input","KEGG_PEROXISOME",-0.35685,-1.05,0.365,7236,0.657,"NUDT19, ACOX3, ACSL5, PEX11B, ACSL1, ACOX1, ACSL3, MLYCD, ABCD4, ACOT8, MVK, ACSL6, PXMP2, PEX12, AMACR, PEX13, ABCD3, CROT, ACOX2, CAT, CRAT, ACSL4, FAR1, EPHX2, SLC27A2",0.437707135543525,0.182434630440219,FALSE
+"H1703","Input","KEGG_PHENYLALANINE_METABOLISM",-0.35798,-1.04,0.385,7974,0.656,"ALDH1A3, PAH, ALDH3A1, MAOA",0.414539270491499,0.18309616062434,FALSE
+"H1703","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.26122,-0.774,0.731,7140,0.921,"PLCB4, PIK3CA, DGKZ, INPP5A, PIP4K2A, PIK3CB, ITPR3, PI4KA, ITPK1, PIP5K1C, PIK3R1, PIK3C2A, PIK3R2, DGKA, DGKB, PIK3CD, INPP5D",0.13608262304214,0.0357403698031511,FALSE
+"H1703","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.61064,1.89,0.024,1405,0.474,"HMOX1, FECH, UROS, BLVRA, HMBS, COX15, BLVRB, CP",1.61978875828839,0.324221658325915,FALSE
+"H1703","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.5948,-1.76,0.0238,7193,0.272,"CPT2, ACOX3, ACSL5, ACSL1, ACOX1, ACSL3, GK, RXRA, PDPK1, ILK, ACSL6, SLC27A4, ACOX2, FABP1, ACSL4, FABP3, PCK1, CYP27A1, FABP2, LPL, HMGCS2, CD36, FADS2, APOC3, SLC27A2, FABP7, ME1",1.62342304294349,0.565431095965801,FALSE
+"H1703","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",-0.55766,-1.69,0.0411,7947,0.305,"AMACR, ACOX2, CYP27A1, AKR1D1",1.38615817812393,0.515700160653214,FALSE
+"H1703","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",0.70651,2.2,0.00487,929,0.319,"CD40, TAP1, ADA, RFXAP, TAP2, RFXANK, IKBKG",2.31247103878537,0.496209316942819,FALSE
+"H1703","Input","KEGG_PRION_DISEASES",-0.25636,-0.755,0.765,8198,0.916,"C9, IL6, NCAM1",0.116338564846382,0.0381045263321496,FALSE
+"H1703","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.22266,-0.646,0.912,7461,0.989,"CCNB2, PIK3CB, GNAI1, BUB1, ADCY9, PIK3R1, MAPK13, PIK3R2, PIK3CD, IGF1R",0.0400051616715838,0.0048037084028206,FALSE
+"H1703","Input","KEGG_PROPANOATE_METABOLISM",0.32583,1,0.4,387,0.959,"ALDH3A2, LDHB, ACACB, ACACA",0.397940008672038,0.0181813928293364,FALSE
+"H1703","Input","KEGG_PROSTATE_CANCER",0.22788,0.704,0.84,587,0.975,"PDGFRA, GSTP1, ATF4, E2F3, PDGFC, RB1",0.0757207139381184,0.0109953843014632,FALSE
+"H1703","Input","KEGG_PROTEASOME",0.26847,0.825,0.648,695,0.978,"PSMB9, SEM1, PSMB8, PSMB10",0.188424994129407,0.00966114521239857,FALSE
+"H1703","Input","KEGG_PROTEIN_EXPORT",-0.36121,-1.09,0.322,6678,0.623,"SEC11A, SEC61A1, HSPA5, SPCS2, SPCS3, SEC11C, SPCS1",0.492144128304169,0.20551195334083,FALSE
+"H1703","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.56241,-1.64,0.0503,8281,0.345,"ATP1A2, GLS, GLS2, PCK1, AQP1, SLC38A3",1.29843201494407,0.462180904926726,FALSE
+"H1703","Input","KEGG_PURINE_METABOLISM",0.22486,0.697,0.857,2422,0.954,"PFAS, ADK, PDE6C, NME1, ADA, RRM2B, NUDT9, NUDT5, NT5C2, PRPS1, PRPS1L1, NME2, IMPDH2, NME3, ATIC, HPRT1, ADSL, GART, PAPSS2, DCK, POLD4, GMPS, PRPS2, GUK1, NUDT2, APRT, NME4, ITPA, NT5C, POLA2, FHIT, POLA1, POLR3G, PAICS",0.0670191780768018,0.0204516252959049,FALSE
+"H1703","Input","KEGG_PYRIMIDINE_METABOLISM",0.21544,0.654,0.914,2369,0.981,"UPP1, TXNRD1, UPRT, NME1, RRM2B, NT5C2, NME2, NME3, DTYMK, CAD, DUT, DCK, DCTD, TK1, TK2, POLD4, NUDT2, NME4, ITPA, NT5C, POLA2, POLA1, POLR3G",0.0390538042661686,0.0083309926200515,FALSE
+"H1703","Input","KEGG_PYRUVATE_METABOLISM",0.32341,0.981,0.43,1365,0.891,"ALDH3A2, LDHB, ACACB, ACACA, ME2, ACYP1, ACAT1, ACYP2, GLO1, AKR1B1",0.366531544420413,0.0501222959631252,FALSE
+"H1703","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.29383,-0.861,0.613,8034,0.895,"MYH14, HRAS, PIP5K1C, ITGA1, IQGAP3, ITGA4, PIK3R1, PDGFRB, ITGB6, ITGB4, RRAS2, ARPC1A, ITGA7, PIK3R2, IQGAP2, ACTN4, SLC9A1, FN1, SCIN, ITGB3, PIK3CD, RAC2, ITGA2, WAS, ITGB8",0.212539525481585,0.048176964684088,FALSE
+"H1703","Input","KEGG_REGULATION_OF_AUTOPHAGY",0.44189,1.31,0.172,1681,0.766,"ATG12, ATG5, GABARAPL1, PIK3C3, ATG7, PIK3R4",0.764471553092451,0.115771230367396,FALSE
+"H1703","Input","KEGG_RENAL_CELL_CARCINOMA",-0.25915,-0.761,0.763,6518,0.915,"JUN, HGF, SOS1, RAPGEF1, CREBBP, RAP1B, PIK3CA, MET, PAK4, TGFA, RAP1A, PIK3CB, TGFB3, VEGFC, HRAS, PIK3R1, PIK3R2, VEGFA, PIK3CD, TGFB2, SLC2A1",0.11747546204512,0.0385789059335517,FALSE
+"H1703","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.39302,-1.18,0.222,7917,0.535,"MME, ACE, ANPEP",0.653647025549361,0.271646217978772,FALSE
+"H1703","Input","KEGG_RETINOL_METABOLISM",-0.45263,-1.34,0.127,8665,0.537,"DGAT1, PNPLA4, DHRS3, RDH10",0.896196279044043,0.270025714300444,FALSE
+"H1703","Input","KEGG_RIBOFLAVIN_METABOLISM",0.64005,1.99,0.00709,1663,0.455,"ACP6, PHPT1, MTMR6",2.14935376481693,0.341988603342888,FALSE
+"H1703","Input","KEGG_RIBOSOME",0.12821,0.378,1,6734,1,"RPS4Y1, RPS29, RPL37, RPL38, RPS21, RPS12, RPS28, RPS3, RPL24, RSL24D1, RPS10, RPL17, RPL36A, RPL36AL, UBA52, RPS5, RPSA, RPS19, RPL10A, FAU, RPL18, RPL12, RPL13A, RPL29, RPS17, RPL35A, RPS15A, RPS15, RPL23, RPS27L, RPL30, RPLP0, RPS9, RPS13, RPL9, RPL22, RPL18A, RPS16, RPS2, RPL3, RPLP1, RPS20, RPL28, RPS24, RPL10, RPL15, RPL6, RPL11, RPL27, RPL7A, RPL4, RPS11, RPL8, RPL26, RPS27A, RPL31, RPL7, RPL34, RPS4X, RPLP2, RPS25, RPL36, RPS23, RPL27A, RPS7, RPL23A, RPS18, RPS8, RPS26, RPL21, MRPL13, RPL13, RPL26L1, RPS3A, RPL5, RPL19, RPL35, RPL37A, RPL32",0,0,FALSE
+"H1703","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.45927,1.43,0.102,2218,0.723,"DDX3Y, AZI2, ATG12, TBKBP1, MAPK9, RIPK1, MAPK10, IKBKG, NFKBIB, RELA, MAP3K7, ATG5, MAPK8, TBK1, DHX58, TANK, TRAF2, SIKE1, IRF3, TRADD, MAPK12",0.991399828238082,0.140861702705469,FALSE
+"H1703","Input","KEGG_RNA_DEGRADATION",0.1837,0.557,0.977,1959,1,"LSM1, ENO1, DCP1B, ENO3, HSPA9, XRN1, LSM6, DCP2, LSM2, LSM7, LSM3",0.0101054362812269,0,FALSE
+"H1703","Input","KEGG_RNA_POLYMERASE",-0.42494,-1.27,0.168,5770,0.597,"POLR2B, POLR3C, POLR2I, POLR2E, POLR2D, POLR2L, POLR1E, POLR2F, POLR3D, POLR3H, POLR3A, POLR3K, POLR3B",0.774690718274137,0.224025668870631,FALSE
+"H1703","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.38246,-1.14,0.29,8174,0.585,"GGT7, GGT5, MARS2, CTH",0.537602002101044,0.23284413391782,FALSE
+"H1703","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.42096,-1.25,0.19,7516,0.582,"SKP2, CDK4, RXRA, PIK3CB, ITGA6, BCL2L1, PIK3R1, TRAF6, LAMB3, LAMC2, PIK3R2, LAMA3, LAMA4, FN1, LAMB1, PIK3CD, ITGA2, CCND1, PTGS2",0.721246399047171,0.235077015350112,FALSE
+"H1703","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.54227,-1.61,0.0551,7091,0.363,"STX12, STX16, GOSR1, VTI1A, STX5, VAMP4, STX10, STX18, SEC22B, SNAP23, STX3, BET1L, VAMP5, VAMP8",1.25884840114821,0.440093374963888,FALSE
+"H1703","Input","KEGG_SPHINGOLIPID_METABOLISM",-0.2792,-0.84,0.637,8252,0.895,"SMPD1, ASAH1, PLPP3, SMPD3",0.19586056766465,0.048176964684088,FALSE
+"H1703","Input","KEGG_SPLICEOSOME",0.3247,0.993,0.415,3774,0.916,"WBP11, PQBP1, ZMAT2, LSM6, SF3B4, SLU7, RBM8A, DHX8, CHERP, LSM2, PPIL1, LSM7, LSM3, HSPA1A, SNW1, LSM4, SMNDC1, HSPA6, SNRNP40, ACIN1, SF3A2, HSPA2, PRPF8, CDC40, SNRNP70, SRSF5, CWC15, ISY1, THOC2, SYF2, THOC1, AQR, MAGOHB, TCERG1, U2AF1, SNRNP27, U2AF2, TXNL4A, HNRNPC, SNRPC, PPIH, ALYREF, HSPA1L, RBMX, THOC3, EFTUD2, CCDC12, PPIE, RBM17, SNRPG, SART1, BUD31, SRSF9, SNRPF, HSPA8, DDX23, BCAS2, PRPF3, SRSF2, SRSF1, LSM8",0.381951903287907,0.0381045263321496,FALSE
+"H1703","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.32918,-0.971,0.461,5743,0.713,"GCK, HK2, PYGB, GBE1, AGL, GAA, PGM2, HK3, GYS1, UXS1, MGAM, UGDH, PGM2L1",0.336299074610352,0.146910470148134,FALSE
+"H1703","Input","KEGG_STEROID_BIOSYNTHESIS",-0.64893,-1.9,0.0157,7678,0.194,"SC5D, LSS, DHCR7, HSD17B7, DHCR24, SQLE, MSMO1, CYP51A1, FDFT1, TM7SF2",1.80410034759077,0.712198270069774,TRUE
+"H1703","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",-0.70082,-2.09,0.00347,6972,0.112,"HSD11B2, SRD5A3, AKR1C3, STS, HSD17B7, AKR1C1, HSD17B12, CYP21A2, AKR1D1, HSD17B8",2.45967052520913,0.950781977329818,TRUE
+"H1703","Input","KEGG_SULFUR_METABOLISM",-0.35586,-1.04,0.361,8090,0.656,"CHST11, SULT1A3",0.442492798094342,0.18309616062434,FALSE
+"H1703","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.41474,1.3,0.157,14,0.738,"CD40",0.804100347590766,0.131943638176958,FALSE
+"H1703","Input","KEGG_TASTE_TRANSDUCTION",-0.32505,-0.947,0.496,7312,0.741,"GNB1, GNB3, GNAS, ITPR3",0.304518323509803,0.130181792020672,FALSE
+"H1703","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.36951,-1.09,0.333,7734,0.623,"MVK, HMGCR, HMGCS1, HMGCS2",0.47755576649368,0.20551195334083,FALSE
+"H1703","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.20776,0.646,0.918,1281,0.976,"TGFBR2, ZFYVE16, E2F5, RPS6KB1, TGFB1, AMH, SMAD4",0.0371573187987575,0.0105501823333082,FALSE
+"H1703","Input","KEGG_THYROID_CANCER",-0.40355,-1.22,0.196,7005,0.549,"TP53, MYC, TCF7L2, TPR, RXRA, PAX8, HRAS, CTNNB1, CCND1",0.707743928643524,0.260427655549908,FALSE
+"H1703","Input","KEGG_TIGHT_JUNCTION",-0.34659,-1.02,0.388,7360,0.654,"PPP2R2A, PRKCD, PPP2R2B, CDK4, RAB3B, PRKCI, CTNNA2, JAM2, GNAI1, PARD6B, CTNNA1, CASK, MYH14, MYH7B, HRAS, SPTAN1, PARD6G, RRAS2, CLDN7, HCLS1, CTNNB1, ACTN4, CLDN3, LLGL2, TJP2, EPB41L3, EPB41L1, F11R",0.411168274405793,0.184422251675733,FALSE
+"H1703","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",0.28064,0.868,0.581,1854,0.984,"CD40, TLR3, CTSK, MAPK9, RIPK1, MAP2K4, MAPK10, IKBKG, MYD88, RELA, MAP3K7, MAPK8, TAB2, TAB1, TBK1",0.235823867609669,0.00700490156865849,FALSE
+"H1703","Input","KEGG_TRYPTOPHAN_METABOLISM",0.45205,1.37,0.138,325,0.734,"KYNU, ALDH3A2, MAOB",0.860120913598763,0.134303940083929,FALSE
+"H1703","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.38145,-1.14,0.257,6958,0.585,"HK3, PIK3CA, PKM, PRKCD, IRS2, PIK3CB, PDX1, PIK3R1, IRS1, PIK3R2, PIK3CD",0.590066876668705,0.23284413391782,FALSE
+"H1703","Input","KEGG_TYROSINE_METABOLISM",0.335,1.03,0.391,2077,0.942,"MAOB, FAH, PNMT, GSTZ1, MIF, ADH5, GOT1, LCMT1, DCT",0.407823242604133,0.0259490972071227,FALSE
+"H1703","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.2842,-0.851,0.638,7033,0.894,"PTPN6, PPP3R1, PIK3CA, PAK4, TEC, PPP3CA, PPP3CC, CDK4, PIK3CB, MAP2K7, PDPK1, VAV3, PTPRC, HRAS, PIK3R1, CBLB, DLG1, MAPK13, LCP2, PIK3R2, PIK3CD, NFATC4",0.195179321278838,0.0486624812040823,FALSE
+"H1703","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",0.25608,0.779,0.724,2750,0.947,"FBXO2, HERC4, VHL, UBE2G1, UBE2L6, FBXW7, ERCC8, XIAP, UBE2E1, UBE2R2, CUL4B, BIRC6, BTRC, UBE2K, UBE2L3, UBE2E2, CDC26, NEDD4L, CUL4A, CUL3, UBE3B, UBE2A, UBE2M, UBE2D4, FBXW11, PIAS4, FBXW8, CUL7, UBE2D2, SMURF2, ANAPC4, PIAS2, SAE1, NEDD4, UBE2H, SKP1, ELOB, UBA6, CUL1",0.140261433802853,0.0236500209967266,FALSE
+"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",-0.26856,-0.787,0.728,2481,0.918,"VARS2, IARS2, PDHB, PDHA1, LARS2, BCAT2",0.137868620686963,0.0371573187987575,FALSE
+"H1703","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",-0.33257,-0.994,0.433,7790,0.696,"BCAT2, HMGCS1, HIBCH, DBT, ABAT, HMGCS2, ALDH6A1, ACADS",0.363512103646635,0.157390760389438,FALSE
+"H1703","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.21836,-0.642,0.943,7041,0.984,"PLA2G12A, PLCB4, MYLK3, ARHGEF12, GNA12, GUCY1A1, PRKCD, MYLK, GNA11, GNAS, PLA2G4A, ITPR3, PPP1R12B, ADCY9, PRKG1",0.0254883072626717,0.00700490156865849,FALSE
+"H1703","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",0.33192,1.02,0.376,1667,0.935,"DYNC1I2, DYNC1I1, DYNC1LI1, DCTN6, DCTN5, DYNC1LI2, DCTN4, DYNC1H1, DYNC2LI1, DCTN2, PRKACA",0.424812155072339,0.0291883891274822,FALSE
+"H1703","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.41155,-1.22,0.203,7041,0.549,"PLA2G12A, PTK2, RAC3, PPP3R1, PIK3CA, PPP3CA, PPP3CC, PIK3CB, PLA2G4A, HRAS, PIK3R1, MAPK13, PIK3R2, VEGFA, PIK3CD, RAC2, NFATC4, PTGS2",0.692503962086787,0.260427655549908,FALSE
+"H1703","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.43289,-1.25,0.166,6031,0.582,"ATP6V1F, SLC12A2, SEC61B, ATP6V1E1, TJP1, ATP6V1A, ATP6V1C2, SEC61A1, ATP6V0A2, ATP6V0C, ATP6V1B2, ATP6V0D1, ATP6V1G2, TCIRG1, ATP6V1D, ATP6V1B1, ATP6V1H, GNAS, PDIA4, ERO1A, ADCY9, TJP2",0.779891911959945,0.235077015350112,FALSE
+"H1703","Input","KEGG_VIRAL_MYOCARDITIS",0.33545,1.03,0.359,1754,0.942,"CD40, CAV1, CXADR, MYH3, CASP9, SGCB, BID, DAG1, MYH10, MYH11, MYH9",0.444905551421681,0.0259490972071227,FALSE
+"H1703","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.26004,-0.778,0.755,6430,0.925,"PPP2R5B, PPP2R1B, TBL1XR1, TCF7L1, JUN, CTBP2, VANGL1, CSNK1A1, PPP2R5E, CREBBP, DVL3, TP53, DVL1, RAC3, PPP3R1, MYC, PLCB4, WNT5A, PPP2CB, TCF7L2, CCND3, PPP3CA, TBL1X, PPP3CC, CAMK2D, APC, CSNK1E, FOSL1, SOX17, PPP2R5C, SENP2, DAAM1, CTNNB1, RAC2, NFATC4, CCND1",0.122053048370812,0.0338582672609674,FALSE
+"H460","Input","KEGG_ABC_TRANSPORTERS",0.55065,1.74,0.0416,931,0.202,"ABCG2, ABCC2, ABCC3, ABCB6, ABCB10, ABCD4, ABCG1, ABCA3",1.38090666937326,0.694648630553376,TRUE
+"H460","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.53944,-1.76,0.0463,6979,0.645,"MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, IKBKB, RPS6KB2, TCF7L2, MAPK1, RARA, PIK3R2, RAF1, RELA, STAT5A, MAPK3, RPS6KB1, AKT2, STAT5B, EIF4EBP1, STAT3",1.33441900898205,0.190440285364732,FALSE
+"H460","Input","KEGG_ADHERENS_JUNCTION",-0.24556,-0.789,0.695,6894,0.807,"FER, FARP2, PTPN1, RHOA, VCL, CDH1, CDC42, TCF7L2, LMO7, MAPK1, NLK, PTPRF, MAPK3, RAC2, BAIAP2, WASL, NECTIN4, PTPN6",0.158015195409886,0.0931264652779296,FALSE
+"H460","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.29557,-0.959,0.437,5653,0.601,"NFKBIB, PRKAA1, NFKB1, RXRA, MTOR, ACSL3, CAMKK2, AKT3, CHUK, PRKAG1, CPT1A, PTPN11, RXRB, PRKAG2, RXRG, AKT1, PRKCQ, STK11, IKBKB, CD36, RELA, ACACB, AKT2, IRS1, STAT3",0.359518563029578,0.22112552799726,FALSE
+"H460","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.26943,0.878,0.575,1174,0.733,"CPS1, GLS, GLS2, GPT2",0.24033215531037,0.134896025358872,FALSE
+"H460","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.30467,-0.976,0.437,6398,0.604,"KRAS, ATP1A4, ATP1A1, ATP1A3, NEDD4L, PIK3CA, PIK3CB, MAPK1, PIK3R2, MAPK3, IRS1",0.359518563029578,0.218963061378868,FALSE
+"H460","Input","KEGG_ALZHEIMERS_DISEASE",0.41924,1.36,0.145,2562,0.411,"ATP5PF, ITPR1, NDUFS6, ATP5PD, HSD17B10, UQCRH, CASP7, ATP5F1D, PLCB4, NDUFA2, NDUFS8, SNCA, NDUFA8, TNFRSF1A, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, APP, NDUFA7, COX5B, COX6B1, COX6A1, NDUFS1, UQCRC1, NDUFA5, ADAM17, NDUFA3, NCSTN, ERN1, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, CALM2, NDUFB8, ATP5F1E, ATP5PB, GNAQ, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, NDUFV1, ATP5MC2, UQCR10, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, ADAM10, ATP5F1A, ATP5PO, LRP1, NDUFB6, NDUFA4L2",0.838631997765025,0.386158178123931,FALSE
+"H460","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",-0.37902,-1.23,0.207,4549,0.435,"YARS2, HARS2, MARS2, CARS2, NARS2, SARS2, WARS2, MTFMT, FARSB, TARS2, PARS2, VARS2, FARSA, SEPSECS",0.684029654543082,0.361510743045363,FALSE
+"H460","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.48321,-1.55,0.0805,6657,0.393,"PMM1, HK2, GMDS, PGM2, UGP2, MPI, NAGK, NANP, GNPDA1, GPI, HK1, AMDHD2, FPGT, GNPNAT1, GALT, GALE, RENBP, PGM3, PGM1, UAP1",1.09420411963213,0.405607449624573,FALSE
+"H460","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",-0.33907,-1.1,0.302,7391,0.49,"CAT, GRIN1, DAXX, PPP3CA, MAPK14, APAF1, CASP1, PPP3CB, MAPK13, MAPK12",0.519993057042849,0.309803919971486,FALSE
+"H460","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",0.33315,1.09,0.313,1319,0.584,"CTSL, B2M, HSPA5, PDIA3, NFYB, CTSB, RFXANK",0.504455662453552,0.233587152887601,FALSE
+"H460","Input","KEGG_APOPTOSIS",-0.23443,-0.742,0.775,7393,0.844,"PIK3CB, AKT1, IRAK4, CASP6, IKBKB, PPP3CA, RIPK1, CAPN2, PIK3R2, RELA, APAF1, PPP3CB, AKT2, CAPN1",0.11069829749369,0.073657553374345,FALSE
+"H460","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",0.34082,1.11,0.308,419,0.596,"GGT1, AKR1C3, PTGES",0.511449283499556,0.224753740259764,FALSE
+"H460","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",-0.30204,-0.967,0.45,7377,0.611,"AMD1, SMS, ASL, CKMT1A, PRODH, PRODH2, CKB, ARG2, ARG1, GATM, AOC1, DAO, GLUD2",0.346787486224656,0.213958789757446,FALSE
+"H460","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",0.41446,1.32,0.149,1073,0.398,"CACNA2D1, ITGB5, DSC2, ITGAV, ITGA5, DES, LMNA, DAG1, DSG2, SGCD, ITGA6",0.826813731587726,0.400116927926312,FALSE
+"H460","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.7103,2.24,0,230,0.0954,"UGDH",Inf,1.0204516252959,TRUE
+"H460","Input","KEGG_AXON_GUIDANCE",-0.37722,-1.21,0.217,7073,0.446,"PLXNC1, PAK3, ROCK1, NFATC3, RHOA, EPHA2, PAK1, PTK2, CDK5, ROCK2, PAK4, GSK3B, CFL1, ARHGEF12, CDC42, PPP3CA, NFAT5, RASA1, EFNB2, MAPK1, SLIT2, ABLIM1, PAK2, SEMA3C, MAPK3, RAC2, EPHB3, PPP3CB, NTN1, RHOD, NGEF, NFATC2, EPHB2",0.66354026615147,0.350665141287858,FALSE
+"H460","Input","KEGG_BASAL_CELL_CARCINOMA",-0.22181,-0.723,0.82,6274,0.84,"FZD7, CTNNB1, STK36, GSK3B, DVL3, TCF7L2",0.0861861476162833,0.0757207139381184,FALSE
+"H460","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.36423,1.17,0.241,2507,0.525,"TAF13, GTF2A2, TAF12, TAF10, GTF2E2, GTF2A1, TAF5L, GTF2H1, TAF1, TAF6L, TAF6, TAF9, TAF4, TAF7, GTF2F2",0.617982957425132,0.279840696594043,FALSE
+"H460","Input","KEGG_BASE_EXCISION_REPAIR",0.19161,0.608,0.94,7077,0.977,"NTHL1, TDG, PARP2, POLD4, LIG3, PARP1, POLE3, XRCC1, MPG, POLD2, POLE4, POLB, FEN1, PCNA, POLD1, APEX1, POLD3, PARP4, MBD4, POLE, LIG1, UNG, HMGB1",0.0268721464003014,0.0101054362812269,FALSE
+"H460","Input","KEGG_BETA_ALANINE_METABOLISM",-0.29499,-0.963,0.434,6104,0.61,"MLYCD, ABAT, EHHADH, SMS, DPYD",0.362510270487489,0.214670164989233,FALSE
+"H460","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",-0.22426,-0.728,0.795,7093,0.841,"HACD2, TECR, ACOT7",0.0996328713435297,0.0752040042020878,FALSE
+"H460","Input","KEGG_BLADDER_CANCER",-0.34042,-1.1,0.295,6398,0.49,"KRAS, NRAS, MAP2K2, CDK4, MAP2K1, CDH1, THBS1, MAPK1, DAPK1, RAF1, MAPK3",0.530177984021837,0.309803919971486,FALSE
+"H460","Input","KEGG_BUTANOATE_METABOLISM",-0.3324,-1.08,0.333,7112,0.504,"AACS, EHHADH, BDH2, ACAT2, HMGCS2, ACSM3, HMGCS1, BDH1",0.47755576649368,0.297569463554475,FALSE
+"H460","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52543,-1.72,0.0391,6194,0.466,"AKT3, CHUK, KRAS, NRAS, BCL10, RAC1, MAP2K2, NFATC3, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, IKBKB, PPP3CA, NFAT5, PLCG2, MAPK1, SYK, PIK3R2, RAF1, RELA, MAPK3, RAC2, VAV2, PPP3CB, AKT2, PTPN6, NFATC2",1.40782324260413,0.33161408331,FALSE
+"H460","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",0.28594,0.922,0.491,1201,0.704,"BST1, CACNA1A, ITPR1, CAMK2D, PLCB4, CAMK4, PLCD3, PRKCB, VDAC1, RYR1, PTK2B, ATP2B1",0.308918507877032,0.152427340857888,FALSE
+"H460","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",0.45636,1.47,0.1,2271,0.37,"CACNA2D1, UQCRH, UQCRFS1, UQCRB, ATP1A2, COX5B, COX6B1, COX6A1, UQCRC1, COX5A, CYC1, SLC8A1, UQCRC2, TPM4, COX7A2, COX7C, TPM3, TPM1, UQCR10",1,0.431798275933005,FALSE
+"H460","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",0.56014,1.81,0.0314,456,0.262,"SDC2, NRCAM, PTPRM, CD274, NCAM2, NCAM1, CD99, L1CAM, CNTN1, PDCD1LG2, JAM3, ITGAV, CD58",1.50307035192679,0.581698708680255,FALSE
+"H460","Input","KEGG_CELL_CYCLE",-0.23427,-0.759,0.772,6113,0.833,"SMAD3, TFDP1, ORC2, ANAPC4, PRKDC, BUB1B, STAG2, RBL1, HDAC1, ABL1, BUB1, PLK1, CUL1, SMC3, CDK4, YWHAB, CDC45, STAG1, GSK3B, YWHAZ, FZR1, CHEK1, CDC23, CDC16, CDK1, CCNA2, CDK2, CCNB1, TTK, PTTG1, WEE1",0.112382699664264,0.0793549985932124,FALSE
+"H460","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.41158,-1.32,0.148,6982,0.448,"HCK, GNG4, ROCK1, GRK6, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PTK2, ROCK2, PIK3CB, AKT1, GSK3B, PXN, IKBKB, CDC42, MAPK1, BCAR1, CCL15, PIK3R2, RAF1, RELA, CSK, MAPK3, RAC2, STAT1, VAV2, CCL13, GRK2, GSK3A, PRKCD, WASL, GNG5, AKT2, STAT5B, ARRB1, CCL14, STAT2, STAT3",0.829738284605043,0.348721986001856,FALSE
+"H460","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.31495,-1.02,0.396,5735,0.553,"PIK3CD, CBL, NFKB1, TGFBR2, SMAD3, AKT3, CHUK, CBLB, KRAS, NRAS, CRKL, HDAC1, ABL1, MAP2K2, PTPN11, CDK4, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, IKBKB, MECOM, MAPK1, PIK3R2, RAF1, RELA, STAT5A, MAPK3, AKT2, STAT5B",0.402304814074488,0.257274868695302,FALSE
+"H460","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.41577,1.35,0.137,2298,0.407,"PDHB, IDH3A, MDH2, SUCLG1, SUCLG2, PDHA1, SDHB, DLAT, DLST, PCK2, DLD, SDHA, ACO2, IDH3G, SDHC",0.863279432843593,0.39040559077478,FALSE
+"H460","Input","KEGG_COLORECTAL_CANCER",-0.21976,-0.728,0.819,7147,0.841,"MAP2K1, RHOA, PIK3CA, PIK3CB, AKT1, GSK3B, TCF7L2, MAPK1, PIK3R2, RAF1, MAPK3, RAC2, AKT2",0.0867160982395816,0.0752040042020878,FALSE
+"H460","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",0.41555,1.32,0.136,1265,0.398,"CD55, MBL2, PLAUR, F3, C9, F5, F8, PROS1, PLAU, C7",0.866461091629782,0.400116927926312,FALSE
+"H460","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",-0.3892,-1.31,0.161,5302,0.427,"SRM, APIP, AHCYL1, LDHB, LDHA, ENOPH1, DNMT1, GOT1, AMD1, SMS, CBS, ADI1, SDS, AHCY",0.79317412396815,0.369572124974976,FALSE
+"H460","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",0.37916,1.24,0.18,618,0.479,"EPO, CXCL5, TNFRSF19, TNFRSF10A, TGFB2, TGFBR1, TNFRSF10B, TNFRSF1A, OSMR, CXCL6",0.744727494896694,0.319664486585437,FALSE
+"H460","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.24465,-0.796,0.73,7666,0.812,"IKBKB, PYCARD, RIPK1, RELA, ZBP1, CASP1, IL18",0.136677139879544,0.0904439707588247,FALSE
+"H460","Input","KEGG_DILATED_CARDIOMYOPATHY",0.42515,1.37,0.125,2322,0.417,"CACNA2D1, TGFB2, ITGB5, ITGAV, ITGA5, DES, LMNA, DAG1, SGCD, ITGA6, ITGA10, ACTG1, SLC8A1, TGFB1, EMD, ITGB1, TPM4, TPM3, GNAS, TPM1, ACTB",0.903089986991944,0.379863945026242,FALSE
+"H460","Input","KEGG_DNA_REPLICATION",-0.19803,-0.631,0.915,4819,0.929,"POLD1, MCM2, RNASEH2B, MCM7, POLA1, POLD3, MCM4, MCM6, RNASEH1, PRIM1, POLE, RFC4, RFC2, LIG1, RFC3, RFC1, RFC5",0.0385789059335517,0.0319842860063582,FALSE
+"H460","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",0.29715,0.95,0.458,1003,0.742,"NOTCH3, NOTCH1, NOTCH2",0.339134521996131,0.129596094720973,FALSE
+"H460","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.39322,1.29,0.147,1773,0.422,"MGST1, GSTM4, GSTM1, ALDH3A1, GSTM2, MGST2, MAOA, ADH4, ADH7, GSTK1",0.832682665251824,0.374687549038326,FALSE
+"H460","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.43429,-1.41,0.123,7379,0.468,"UPP1, HPRT1, NAT1, TK1, TK2, DPYD, TPMT, UCKL1",0.910094888560602,0.329754146925876,FALSE
+"H460","Input","KEGG_ECM_RECEPTOR_INTERACTION",0.55457,1.79,0.0266,818,0.22,"SDC2, COL5A2, FN1, SPP1, LAMB1, HSPG2, LAMA1, LAMC1, ITGB5, LAMA5, ITGAV, ITGA5, VTN, LAMB2, THBS3, DAG1, COL6A1, COL4A6",1.57511836336893,0.657577319177794,TRUE
+"H460","Input","KEGG_ENDOCYTOSIS",-0.34822,-1.15,0.25,6029,0.479,"HSPA1A, DNM2, CHMP3, VPS4B, GIT2, VPS28, RAB5A, PARD6G, CBLB, SMAP2, IQSEC2, ARFGAP1, ARFGAP3, CHMP4A, CHMP4B, VPS25, CHMP4C, VPS37B, PIP5K1A, NEDD4L, EPS15, VTA1, RAB11A, SH3GL1, ITCH, GRK6, EHD1, EHD2, DAB2, RAB11FIP1, TRAF6, ARAP1, WWP1, IQSEC1, PDCD6IP, RAB5C, SH3GLB2, CDC42, ACAP2, SH3GLB1, CHMP2A, FGFR2, CLTC, ASAP1, SMURF2, EHD3, CHMP5, SMAP1, DNM1, LDLRAP1, CHMP2B, GRK2, ERBB3, PRKCI, ARFGAP2, ARRB1, ARAP3, DNM1L",0.602059991327962,0.319664486585437,FALSE
+"H460","Input","KEGG_ENDOMETRIAL_CANCER",-0.3979,-1.26,0.198,6194,0.432,"AKT3, CTNNB1, KRAS, NRAS, MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, CDH1, TCF7L2, MAPK1, PIK3R2, RAF1, MAPK3, AKT2",0.703334809738469,0.364516253185088,FALSE
+"H460","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",-0.31666,-1.04,0.364,7666,0.544,"IKBKB, CDC42, PLCG2, F11R, PLCG1, MAPK14, RELA, CSK, MAPK13, MAP2K4, MAPK12",0.438898616350944,0.26440110030182,FALSE
+"H460","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.42375,-1.36,0.128,6979,0.446,"MAP2K2, PAK3, MAP2K1, PIK3CA, PAK1, SOS1, PTK2, PAK4, PIK3CB, AKT1, GSK3B, GAB1, RPS6KB2, PLCG2, MAPK1, PLCG1, PAK2, PIK3R2, RAF1, STAT5A, MAPK3, RPS6KB1, ERBB3, AKT2, STAT5B, EIF4EBP1, MAP2K4, TGFA, ABL2",0.892790030352132,0.350665141287858,FALSE
+"H460","Input","KEGG_ETHER_LIPID_METABOLISM",-0.23858,-0.791,0.717,7332,0.812,"PAFAH1B3, LPCAT4, PAFAH2, LPCAT2",0.1444808443322,0.0904439707588247,FALSE
+"H460","Input","KEGG_FATTY_ACID_METABOLISM",0.25942,0.831,0.661,1769,0.782,"ACAA2, ACADSB, ECHS1, ACADS, ECI1, ACAT1, ADH4, ADH7",0.17979854051436,0.106793246940152,FALSE
+"H460","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.48251,-1.57,0.0664,6979,0.387,"MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, SYK, MAPK14, PIK3R2, RAF1, MAPK3, RAC2, VAV2, PRKCD, AKT2, MAPK13, MAP2K4, MAPK12",1.17783192063198,0.412289034981089,FALSE
+"H460","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.50299,-1.63,0.0441,6982,0.378,"HCK, ARPC1A, MAP2K1, PIK3CA, PAK1, PIK3CB, AKT1, ARPC4, ARPC3, CFL1, VASP, CDC42, RPS6KB2, PLCG2, SCIN, ARPC2, MAPK1, MYO10, PLCG1, SYK, PIK3R2, RAF1, ASAP1, MARCKSL1, MAPK3, RAC2, VAV2, GSN, DNM1, RPS6KB1, PRKCD, WASL, AKT2, PTPRC, MARCKS, DNM1L",1.35556141053216,0.422508200162775,FALSE
+"H460","Input","KEGG_FOCAL_ADHESION",0.27835,0.928,0.522,472,0.707,"COL5A2, FN1, SPP1, LAMB1, PIK3R3, LAMA1, LAMC1, ITGB5, LAMA5, FLNB, ITGAV, ITGA5, VTN, CAV2, LAMB2, THBS3",0.282329496997738,0.150580586203101,FALSE
+"H460","Input","KEGG_FOLATE_BIOSYNTHESIS",-0.51655,-1.67,0.0513,7763,0.381,"DHFR, ALPG, ALPI, ALPP",1.28988263488818,0.419075024324381,FALSE
+"H460","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.4599,-1.51,0.0848,6110,0.391,"MTMR1, ALDOC, PFKFB3, PFKP, PMM1, HK2, TPI1, GMDS, PFKM, MTMR6, MPI, HK1, FPGT, PFKFB2, PFKFB4, PFKL, FBP1",1.07160414774329,0.407823242604133,FALSE
+"H460","Input","KEGG_GALACTOSE_METABOLISM",-0.41733,-1.34,0.132,6503,0.445,"PFKP, HK2, PFKM, PGM2, UGP2, MGAM, HK1, GALT, GALE, PGM1, PFKL",0.87942606879415,0.351639989019068,FALSE
+"H460","Input","KEGG_GAP_JUNCTION",-0.3032,-0.985,0.441,5952,0.597,"ADCY5, TUBB4B, HTR2B, GNAI3, TUBB6, KRAS, NRAS, PRKACB, PLCB3, MAPK7, MAP2K2, MAP2K1, SOS1, TUBA1B, TUBB3, TUBB1, TUBB, MAPK1, TUBB2A, RAF1, CDK1, MAPK3, CSNK1D, TUBA1C",0.355561410532161,0.224025668870631,FALSE
+"H460","Input","KEGG_GLIOMA",-0.34386,-1.1,0.303,6979,0.49,"MAP2K2, CDK4, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.518557371497695,0.309803919971486,FALSE
+"H460","Input","KEGG_GLUTATHIONE_METABOLISM",0.24851,0.799,0.697,331,0.8,"MGST1, GGT1, GSTM4, GSTM1",0.156767221901991,0.0969100130080564,FALSE
+"H460","Input","KEGG_GLYCEROLIPID_METABOLISM",-0.28815,-0.926,0.49,8160,0.651,"DGKA, MGLL, DGKH",0.309803919971486,0.186419011431808,FALSE
+"H460","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.34491,-1.11,0.285,7585,0.514,"LPCAT4, MBOAT2, MBOAT7, CHKB, DGKA, PCYT2, PEMT, LPCAT2, CHKA, DGKH",0.54515513999149,0.289036881004724,FALSE
+"H460","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",-0.32315,-1.06,0.359,6143,0.528,"PSPH, SARDH, DMGDH, SRR, SHMT1, CBS, SDS, GATM, DAO",0.444905551421681,0.277366077466188,FALSE
+"H460","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.41707,-1.31,0.181,6301,0.427,"ALDOC, LDHA, GALM, PFKP, BPGM, HK2, PGAM1, PGAM4, TPI1, AKR1A1, PFKM, ADH5, PGM2, ACSS2, GPI, HK1, ADH1C, ALDH1A3, PKLR, PGM1, PFKL, FBP1, PKM",0.742321425130815,0.369572124974976,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",0.2905,0.934,0.495,6210,0.725,"CHPF2, CHST3, DSE, CHSY1, B3GAT3, CHPF, B4GALT7, XYLT2, B3GALT6",0.305394801066431,0.139661993429006,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",-0.36162,-1.17,0.26,5838,0.467,"XYLT2, B3GALT6, EXTL3, NDST2, HS2ST1",0.585026652029182,0.330683119433888,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",0.26235,0.832,0.63,380,0.794,"ST3GAL2",0.200659450546418,0.100179497572904,FALSE
+"H460","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",0.70444,2.25,0.00202,2263,0.139,"GNS, IDS, HEXB, HEXA, GLB1, ARSB, GUSB, IDUA, GALNS",2.69464863055338,0.856985199745905,TRUE
+"H460","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.64575,2.11,0,970,0.104,"B4GALNT1, ST3GAL2, HEXB, HEXA",Inf,0.98296666070122,TRUE
+"H460","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",-0.50746,-1.66,0.0396,5131,0.364,"PIGK, PIGT, GPAA1, PGAP1, PIGQ, PIGH, PIGM, PIGU",1.40230481407449,0.438898616350944,FALSE
+"H460","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.23526,0.763,0.764,2095,0.852,"MTHFD2, MDH2, HAO1, ACO2",0.11690664142431,0.0695604052332999,FALSE
+"H460","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.32237,-1.02,0.401,6398,0.553,"KRAS, NRAS, MAP3K3, PRKACB, PLCB3, MAPK7, MAP2K2, MAP2K1, SOS1, CDC42, MAPK1, MMP14, MAP3K4, MAPK14, RAF1, MAPK3, PRKCD, MAPK13, MAP2K4, MAPK12, MAP3K1",0.396855627379818,0.257274868695302,FALSE
+"H460","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.33353,-1.08,0.33,7225,0.504,"STK36, GSK3B, CSNK1G2, BTRC, CSNK1A1, CSNK1D",0.481486060122112,0.297569463554475,FALSE
+"H460","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",0.41187,1.32,0.153,454,0.398,"CD55, EPO, ITGA5, CD14",0.815308569182401,0.400116927926312,FALSE
+"H460","Input","KEGG_HISTIDINE_METABOLISM",-0.40967,-1.31,0.167,7838,0.427,"TRMT11, METTL2B, LCMT1, ALDH1A3, HDC, AOC1",0.777283528852417,0.369572124974976,FALSE
+"H460","Input","KEGG_HOMOLOGOUS_RECOMBINATION",0.31013,1.02,0.395,2061,0.669,"SSBP1, RAD51, RAD54L, MUS81, POLD4, MRE11",0.40340290437354,0.174573882232177,FALSE
+"H460","Input","KEGG_HUNTINGTONS_DISEASE",0.4545,1.44,0.12,2579,0.365,"ATP5PF, ITPR1, NDUFS6, ATP5PD, UQCRH, ATP5F1D, PLCB4, NDUFA2, NDUFS8, POLR2H, NDUFA8, CLTA, SOD2, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, POLR2C, NDUFA7, COX5B, COX6B1, VDAC1, CLTB, COX6A1, POLR2L, NDUFS1, POLR2D, UQCRC1, NDUFA5, NDUFA3, POLR2E, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, AP2A2, NDUFB8, ATP5F1E, POLR2I, ATP5PB, GNAQ, POLR2F, SDHA, NDUFB2, UQCRC2, COX7A2, POLR2G, NDUFA4, COX7C, AP2A1, NDUFV1, ATP5MC2, UQCR10, SLC25A6, SDHC, NDUFS5, TAF4, NDUFAB1, NDUFB3, CREB5, NDUFC1, VDAC2, ATP5F1A, ATP5PO, NDUFB6, NDUFA4L2, SIN3A, SLC25A31",0.920818753952375,0.437707135543525,FALSE
+"H460","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",0.43064,1.4,0.126,2003,0.395,"CACNA2D1, PRKAA2, TGFB2, ITGB5, ITGAV, ITGA5, DES, LMNA, DAG1, SGCD, ITGA6, ITGA10, ACTG1, SLC8A1, TGFB1, EMD, ITGB1, TPM4",0.899629454882437,0.40340290437354,FALSE
+"H460","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42467,-1.38,0.115,6275,0.462,"MINPP1, INPP5K, INPP4B, PIP4K2A, PIP5K1A, TPI1, PLCB3, PIK3CA, OCRL, PIK3CB, IMPA1, INPPL1, PLCG2, PLCG1, INPP1, INPP5B, PIK3C2B, SYNJ2, ISYNA1",0.939302159646388,0.335358024443874,FALSE
+"H460","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.39645,-1.28,0.171,6303,0.435,"PPP1R3D, INPP5K, PRKAG1, CBLB, KRAS, NRAS, RHEB, CRKL, HK2, PRKACB, EXOC7, ACACA, FLOT2, MAP2K2, GYS1, PTPN1, MAP2K1, PRKAG2, PIK3CA, SOS1, PIK3CB, AKT1, RPS6, GSK3B, HK1, IKBKB, RPS6KB2, PHKG2, MAPK1, PIK3R2, RAF1, PTPRF, MAPK3, PKLR, RPS6KB1, ACACB, TSC2, AKT2, PRKCI, FBP1, EIF4EBP1, IRS1, MKNK1",0.767003889607846,0.361510743045363,FALSE
+"H460","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.43838,-1.41,0.118,7000,0.468,"PTPN11, SPRY2, IRF9, PIK3CA, SOS1, IFNGR1, PIK3CB, AKT1, PIAS4, PIK3R2, STAT5A, STAT1, SPRY1, AKT2, STAT5B, SPRY4, PTPN6, STAT2, STAT3, PIAS2",0.928117992693875,0.329754146925876,FALSE
+"H460","Input","KEGG_LEISHMANIA_INFECTION",-0.52159,-1.7,0.0263,7378,0.404,"IFNGR1, TAB2, IRAK4, TRAF6, ITGA4, MAPK1, MAPK14, RELA, C3, MARCKSL1, MAPK3, STAT1, MAPK13, PTPN6, MAPK12",1.58004425151024,0.393618634889395,FALSE
+"H460","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.38753,-1.24,0.199,6642,0.431,"ICAM1, CDH5, RAC1, SIPA1, EZR, PTPN11, ROCK1, RHOA, PIK3CA, PTK2, ROCK2, PIK3CB, VCL, PXN, VASP, CDC42, PLCG2, F11R, ITGA4, ARHGAP5, BCAR1, PLCG1, MAPK14, PIK3R2, ARHGAP35, CLDN7, RAC2, VAV2, MAPK13, CLDN3, MAPK12, CLDN18",0.701146923590293,0.365522729839268,FALSE
+"H460","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.29146,0.951,0.478,789,0.757,"ECHS1",0.320572103387881,0.120904120499927,FALSE
+"H460","Input","KEGG_LONG_TERM_DEPRESSION",0.25071,0.813,0.683,951,0.801,"CACNA1A, ITPR1, PLCB4, PRKCB, RYR1",0.165579296318467,0.0963674839157623,FALSE
+"H460","Input","KEGG_LONG_TERM_POTENTIATION",0.22627,0.738,0.775,725,0.84,"ITPR1, CAMK2D, PLCB4, CAMK4, PRKCB",0.11069829749369,0.0757207139381184,FALSE
+"H460","Input","KEGG_LYSINE_DEGRADATION",0.22704,0.738,0.802,1837,0.84,"SETD7, ECHS1, ASH1L, SETMAR, KMT5C, ACAT1, DLST, EHMT2, TMLHE",0.0958256317158365,0.0757207139381184,FALSE
+"H460","Input","KEGG_LYSOSOME",0.497,1.61,0.064,1208,0.257,"GALC, CTSL, CTSC, CTSZ, CTSV, AGA, GLA, GNS, ASAH1, PPT1, ARSA, IDS, LAMP2, IGF2R, LAMP3, HEXB, TCIRG1, CTSK, CTSO, CLTA, PPT2, CLN3, CLTB, GAA, LAMP1, NAGA, HEXA, PSAP, CTSB, CTSE, CTSF, M6PR, SCARB2",1.19382002601611,0.590066876668705,FALSE
+"H460","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.34396,-1.11,0.294,5979,0.514,"PPM1A, MAP3K7, HSPA1A, TAOK2, DUSP3, RPS6KA4, CASP3, AKT3, TAB1, CHUK, MAP3K20, SRF, RPS6KA6, ELK4, TAOK3, KRAS, NRAS, MAPT, IL1A, CRKL, MAP3K3, PRKACB, RAC1, MAPK7, MAP2K2, DUSP1, PPM1B, RPS6KA1, MAP2K1, RELB, PAK1, SOS1, AKT1, TAB2, MAPKAPK2, TRAF6, DAXX, IKBKB, MECOM, CDC42, PPP3CA, RASA1, MAP4K3, MAPK1, MAP3K4, PAK2, NLK, MAPK14, FGFR2, RAF1, RELA, MAPK3, RAC2, PPP5C, MAP3K6, HSPB1, PPP3CB, AKT2, ARRB1, MAPK13, MAP2K4, STMN1, MAPK12, NFATC2, MAP3K1, MKNK1",0.531652669587843,0.289036881004724,FALSE
+"H460","Input","KEGG_MELANOGENESIS",-0.34364,-1.11,0.306,6174,0.514,"GNAI3, FZD7, CTNNB1, KRAS, NRAS, PRKACB, PLCB3, MAP2K2, MAP2K1, GSK3B, DVL3, TYRP1, TCF7L2, MAPK1, RAF1, MAPK3, DCT, CREB3L1, TYR",0.51427857351842,0.289036881004724,FALSE
+"H460","Input","KEGG_MELANOMA",-0.37259,-1.17,0.245,6979,0.467,"MAP2K2, CDK4, MAP2K1, PIK3CA, HGF, PIK3CB, AKT1, CDH1, MAPK1, PIK3R2, RAF1, MAPK3, AKT2",0.610833915635468,0.330683119433888,FALSE
+"H460","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.47525,1.52,0.0858,353,0.333,"MGST1, CYP1B1, AKR1C3, GSTM4, AKR1C1, GSTM1, ALDH3A1",1.06651271215129,0.47755576649368,FALSE
+"H460","Input","KEGG_MISMATCH_REPAIR",-0.256,-0.811,0.659,5360,0.794,"POLD3, MSH6, MSH2, PMS2, RFC4, RFC2, LIG1, RFC3, RFC1, RFC5",0.18111458540599,0.100179497572904,FALSE
+"H460","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.39873,-1.29,0.175,5735,0.443,"PIK3CD, PRKAA1, STRADA, MTOR, RICTOR, AKT3, RPS6KA6, RHEB, CAB39, RPS6KA1, PIK3CA, PIK3CB, AKT1, RPS6, STK11, RPS6KB2, MAPK1, PIK3R2, MAPK3, RPS6KB1, TSC2, AKT2, EIF4EBP1",0.756961951313706,0.35359627377693,FALSE
+"H460","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.37912,-1.22,0.216,6979,0.441,"MAP2K2, PTPN11, NFATC3, MAP2K1, PIK3CA, PAK1, SOS1, IFNGR1, PIK3CB, PPP3CA, NFAT5, PLCG2, MAPK1, PLCG1, SYK, PIK3R2, RAF1, MAPK3, RAC2, VAV2, MICB, PPP3CB, PTPN6, NFATC2",0.665546248849069,0.355561410532161,FALSE
+"H460","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.22772,-0.728,0.796,6008,0.841,"ADRA2A, P2RX4, HTR2B, TSPO, GRIN1, NR3C1, P2RY2",0.0990869322623309,0.0752040042020878,FALSE
+"H460","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.4285,-1.36,0.148,6750,0.446,"RAC1, ABL1, MAPK7, MAP2K2, PTPN11, MAGED1, YWHAB, RPS6KA1, MAP2K1, RHOA, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, ARHGDIB, GAB1, YWHAZ, IRAK4, MAPKAPK2, TRAF6, IKBKB, CDC42, PLCG2, MAPK1, PLCG1, SORT1, MAPK14, PIK3R2, RAF1, RELA, CSK, MAPK3, PRKCD, AKT2, NGFR, MAPK13, IRS1, MAPK12, MAP3K1",0.829738284605043,0.350665141287858,FALSE
+"H460","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",0.27037,0.873,0.587,1972,0.73,"BST1, NAMPT, NT5C, ENPP1, CD38",0.231361898752386,0.136677139879544,FALSE
+"H460","Input","KEGG_NITROGEN_METABOLISM",0.37242,1.2,0.216,1024,0.492,"CPS1, CA12, GLS, GLS2",0.665546248849069,0.30803489723264,FALSE
+"H460","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.52591,-1.7,0.0317,7509,0.404,"TAB2, TRAF6, IKBKB, PYCARD, HSP90AA1, MAPK1, MAPK14, RELA, MAPK3, CCL13, HSP90AB1, CASP1, IL18, MAPK13, MAPK12",1.49894073778225,0.393618634889395,FALSE
+"H460","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.20529,-0.669,0.885,5365,0.897,"NHEJ1, XRCC6, PRKDC, DCLRE1C",0.0530567293021746,0.0472075569559079,FALSE
+"H460","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.3823,-1.25,0.184,6979,0.436,"MAP2K2, CDK4, RXRB, MAP2K1, RXRG, PIK3CA, SOS1, PIK3CB, AKT1, PLCG2, MAPK1, PLCG1, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.735182176990464,0.360513510731414,FALSE
+"H460","Input","KEGG_NOTCH_SIGNALING_PATHWAY",0.3435,1.1,0.302,1143,0.582,"NOTCH3, NOTCH1, NOTCH2, ADAM17, NCSTN",0.519993057042849,0.235077015350112,FALSE
+"H460","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",0.17053,0.545,0.969,7264,0.998,"XPA, GTF2H5, CETN2, RAD23B, POLD4, RBX1, XPC, GTF2H1, POLE3, RPA3, ERCC1, GTF2H2, DDB2, MNAT1, POLD2, CCNH, RAD23A, POLE4, RPA2, ERCC4, GTF2H3, RPA1, PCNA, DDB1, POLD1, GTF2H4, ERCC3, POLD3, ERCC2, CUL4B, ERCC5, CDK7, POLE, RFC4, RFC2, LIG1, RFC3, RFC1, CUL4A, ERCC6, RFC5",0.0136762229492347,0.000869458712628891,FALSE
+"H460","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.22316,0.727,0.801,157,0.845,"TUSC3, MGAT4B",0.0963674839157623,0.0731432910503077,FALSE
+"H460","Input","KEGG_OLFACTORY_TRANSDUCTION",0.33393,1.07,0.351,1601,0.605,"CAMK2D, CNGB1, CALM2",0.454692883534176,0.218244625347531,FALSE
+"H460","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",-0.34095,-1.1,0.303,6197,0.49,"MTHFD1, MTHFR, GART, SHMT1, MTHFS, DHFR, ALDH1L1",0.518557371497695,0.309803919971486,FALSE
+"H460","Input","KEGG_OOCYTE_MEIOSIS",-0.37866,-1.24,0.193,6624,0.431,"PPP2R1A, PPP2CA, PRKACB, BUB1, PLK1, CUL1, SMC3, YWHAB, RPS6KA1, MAP2K1, PPP2R5C, YWHAZ, CDC23, PPP3CA, MAPK1, PPP2R5B, CDC16, BTRC, PPP2R5A, CDK1, MAPK3, PPP2R5E, PPP3CB, AURKA, PPP2R5D, FBXO5, CDK2, CCNB1, PTTG1, MAPK12",0.714442690992226,0.365522729839268,FALSE
+"H460","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.5695,1.8,0.0267,2199,0.239,"AGA, HEXB, HEXA, MAN2B2, MAN2B1, GLB1, GBA, FUCA2",1.57348873863542,0.621602099051862,TRUE
+"H460","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.54277,1.72,0.0341,2564,0.186,"ATP5PF, NDUFS6, ATP5PD, UQCRH, ATP5F1D, NDUFA2, TCIRG1, NDUFS8, NDUFA8, NDUFV2, UQCRFS1, PPA2, UQCRB, NDUFS4, ATP5F1B, ATP5ME, NDUFA7, COX5B, COX6B1, COX6A1, NDUFS1, UQCRC1, NDUFA5, NDUFA3, ATP6V1F, NDUFV3, SDHB, COX5A, COX17, CYC1, NDUFS3, NDUFB8, ATP5F1E, ATP5PB, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, ATP5MG, NDUFV1, ATP6AP1, ATP5MC2, ATP6V1E1, UQCR10, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, ATP5F1A, ATP5PO, ATP6V0C, NDUFB6, NDUFA4L2, ATP6V1G1",1.4672456210075,0.730487055782084,TRUE
+"H460","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",-0.46817,-1.54,0.0538,8748,0.387,"GCNT3",1.26921772433361,0.412289034981089,FALSE
+"H460","Input","KEGG_P53_SIGNALING_PATHWAY",-0.31637,-1.01,0.392,7624,0.561,"RRM2, CHEK1, THBS1, CDK1, APAF1, TSC2, CD82, CDK2, CCNB1",0.406713932979543,0.251037138743839,FALSE
+"H460","Input","KEGG_PANCREATIC_CANCER",-0.32008,-1.04,0.369,7011,0.544,"CDK4, MAP2K1, PIK3CA, BRCA2, PIK3CB, AKT1, IKBKB, CDC42, MAPK1, PIK3R2, RAF1, RELA, MAPK3, RAC2, STAT1, AKT2, STAT3, TGFA",0.43297363384094,0.26440110030182,FALSE
+"H460","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.41762,-1.35,0.14,7826,0.446,"DPYD, COASY, PANK4",0.853871964321762,0.350665141287858,FALSE
+"H460","Input","KEGG_PARKINSONS_DISEASE",0.5456,1.73,0.0343,2579,0.194,"UCHL1, ATP5PF, NDUFS6, ATP5PD, UQCRH, ATP5F1D, NDUFA2, NDUFS8, SNCA, NDUFA8, NDUFV2, UQCRFS1, UQCRB, NDUFS4, ATP5F1B, NDUFA7, COX5B, COX6B1, VDAC1, COX6A1, UBE2G2, HTRA2, NDUFS1, UQCRC1, NDUFA5, NDUFA3, CYCS, NDUFV3, SDHB, COX5A, CYC1, NDUFS3, NDUFB8, ATP5F1E, ATP5PB, SDHA, NDUFB2, UQCRC2, COX7A2, NDUFA4, COX7C, NDUFV1, ATP5MC2, UQCR10, SLC25A6, SDHC, NDUFS5, NDUFAB1, NDUFB3, NDUFC1, VDAC2, ATP5F1A, ATP5PO, NDUFB6, NDUFA4L2, SLC25A31",1.46470587995723,0.712198270069774,TRUE
+"H460","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.43898,-1.39,0.132,5720,0.462,"YWHAQ, TUBA3C, FYN, TUBB4B, NCK1, TUBB6, CTNNB1, ARPC1B, ABL1, HCLS1, EZR, ARPC1A, ROCK1, RHOA, ROCK2, TUBA1B, ARPC4, TUBB3, TUBB1, YWHAZ, CDH1, ARPC3, CDC42, TUBB, ARPC2, TUBB2A, WASL, CTTN, TUBA1C",0.87942606879415,0.335358024443874,FALSE
+"H460","Input","KEGG_PATHWAYS_IN_CANCER",-0.23294,-0.765,0.758,6941,0.832,"LAMB3, GSTP1, MAP2K2, CDK4, CUL2, RXRB, MAP2K1, CKS1B, RHOA, RXRG, PIK3CA, STK36, BRCA2, HGF, SOS1, PTK2, TFG, PIK3CB, AKT1, GSK3B, PIAS4, ARNT, CDH1, TRAF6, IKBKB, MECOM, CDC42, DVL3, HSP90AA1, PLCG2, TCF7L2, MAPK1, DAPK1, PLCG1, RARA, LAMA3, LAMA4, PIK3R2, FGFR2, RAF1, RELA, STAT5A, MAPK3, TRAF3, RAC2, STAT1, NCOA4, HSP90AB1, AKT2, STAT5B, CDK2, STAT3, PIAS2, TGFA",0.120330794367946,0.0798766737092761,FALSE
+"H460","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.28819,-0.922,0.489,6725,0.641,"RPE, UGP2, XYLB, CRYL1",0.31069114087638,0.193141970481183,FALSE
+"H460","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.52521,-1.72,0.0341,6028,0.466,"RBKS, ALDOC, PFKP, RPE, PRPS2, PGLS, PFKM, RPIA, PGM2, GPI, DERA, PGM1, PFKL, FBP1",1.4672456210075,0.33161408331,FALSE
+"H460","Input","KEGG_PEROXISOME",-0.21418,-0.681,0.876,7303,0.891,"EHHADH, CAT, CRAT, IDH2, PEX6, MVK, FAR1, DAO, FAR2",0.0574958938319193,0.0501222959631252,FALSE
+"H460","Input","KEGG_PHENYLALANINE_METABOLISM",0.27242,0.895,0.57,1755,0.743,"ALDH3A1, GOT2, MAOA",0.244125144327509,0.129011186239425,FALSE
+"H460","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.34129,-1.1,0.298,6587,0.49,"INPP4B, PIP4K2A, PIP5K1A, CDS2, PLCB3, PIK3CA, OCRL, PIK3CB, IMPA1, INPPL1, PLCG2, PLCG1, INPP1, PIK3R2, DGKA, INPP5B, PIK3C2B, SYNJ2, DGKH",0.525783735923745,0.309803919971486,FALSE
+"H460","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.38312,1.23,0.193,2696,0.479,"HMOX1, ALAS1, FECH, HMOX2, HCCS, PPOX, GUSB, UGT2B17, EARS2, FTH1",0.714442690992226,0.319664486585437,FALSE
+"H460","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2417,-0.771,0.763,7109,0.83,"RXRB, DBI, CYP27A1, RXRG, EHHADH, CD36, FABP2, HMGCS2, FABP3",0.11747546204512,0.0809219076239261,FALSE
+"H460","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.45982,1.45,0.113,129,0.374,"AKR1D1",0.94692155651658,0.42712839779952,FALSE
+"H460","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.46106,-1.48,0.0985,6546,0.417,"TAP2, UNG, ADA, DCLRE1C, PTPRC",1.00656376950239,0.379863945026242,FALSE
+"H460","Input","KEGG_PRION_DISEASES",0.54598,1.76,0.0332,689,0.201,"NCAM2, NCAM1, LAMC1, C9, HSPA5, NOTCH1",1.47886191629596,0.696803942579511,TRUE
+"H460","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.3699,-1.19,0.243,7138,0.465,"RPS6KA1, MAP2K1, PIK3CA, PIK3CB, AKT1, FZR1, CDC23, HSP90AA1, MAPK1, CDC16, MAPK14, PIK3R2, RAF1, CDK1, MAPK3, HSP90AB1, CCNA2, AKT2, CDK2, CCNB1, MAPK13, MAPK12",0.614393726401688,0.332547047110046,FALSE
+"H460","Input","KEGG_PROPANOATE_METABOLISM",0.27859,0.892,0.556,1587,0.735,"ACSS3, MCEE, ECHS1, SUCLG1, SUCLG2, ACAT1, PCCB",0.254925208417942,0.133712660915805,FALSE
+"H460","Input","KEGG_PROSTATE_CANCER",-0.44992,-1.41,0.126,6950,0.468,"GSTP1, MAP2K2, MAP2K1, PIK3CA, SOS1, PIK3CB, AKT1, GSK3B, IKBKB, HSP90AA1, TCF7L2, MAPK1, PIK3R2, FGFR2, RAF1, RELA, MAPK3, HSP90AB1, CREB3L1, AKT2, CDK2, TGFA",0.899629454882437,0.329754146925876,FALSE
+"H460","Input","KEGG_PROTEASOME",0.15261,0.489,0.998,6839,0.996,"PSMB9, PSMB7, PSMA5, PSMC3, PSMB6, PSMA1, PSMC4, PSMA2, PSMB3, PSMC5, PSMD14, PSMB5, PSMC1, PSMA6, PSMC2, PSMC6, PSMA3, PSMB4, PSMD4, PSMA4, POMP, PSMD7, PSMA7, PSME3, PSMB2, PSMB10, PSMB8, PSMA8, PSMD8, PSMD13, PSMD11, PSMB1, PSMF1, PSMD6, PSMD2, PSMD12, PSMD1, PSME4, SEM1, PSME1, PSMD3",0.000869458712628891,0.00174066157630127,FALSE
+"H460","Input","KEGG_PROTEIN_EXPORT",0.23327,0.744,0.761,622,0.87,"HSPA5, SPCS1",0.118615343229427,0.0604807473813815,FALSE
+"H460","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",-0.27386,-0.864,0.595,8202,0.73,"MDH1, GLUD2",0.22548303427145,0.136677139879544,FALSE
+"H460","Input","KEGG_PURINE_METABOLISM",0.28608,0.935,0.499,1909,0.739,"PAPSS2, PDE3B, PDE4D, PDE3A, POLR3H, NUDT9, POLR3K, POLR2H, POLR3D, GDA, POLR2C, NME4, POLR2L, POLR2D, POLR1E, AK2, NT5C, POLR2E, GUK1, POLR3GL, PRUNE1, POLR3G, POLR3C, ENPP1, POLD4, NME3, POLR2I, PFAS, PNPT1, POLR3F, POLR2F",0.30189945437661,0.131355561605174,FALSE
+"H460","Input","KEGG_PYRIMIDINE_METABOLISM",0.29286,0.941,0.496,1909,0.743,"POLR3H, POLR3K, POLR2H, POLR3D, TXNRD2, POLR2C, NME4, POLR2L, UPRT, TXNRD1, POLR2D, POLR1E, DUT, NT5C, POLR2E, TYMP, POLR3GL, POLR3G, POLR3C, POLD4, NME3, POLR2I, PNPT1, POLR3F, POLR2F",0.304518323509803,0.129011186239425,FALSE
+"H460","Input","KEGG_PYRUVATE_METABOLISM",-0.26043,-0.858,0.601,6912,0.732,"ACACA, ACYP1, ACSS2, GLO1, ACAT2, MDH1, PKLR, ACACB, PKM",0.22112552799726,0.135488918941608,FALSE
+"H460","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.38927,-1.27,0.163,6398,0.438,"KRAS, NRAS, ARPC1B, WASF2, CRKL, FGD3, PIP4K2A, CYFIP1, PIP5K1A, ITGA2, RAC1, SLC9A1, ARHGEF1, EZR, MAP2K2, IQGAP3, ARPC1A, ARHGEF7, PAK3, ROCK1, ITGB6, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PTK2, ROCK2, PAK4, PIK3CB, RDX, VCL, ARPC4, DIAPH3, MYH10, ARPC3, PXN, CFL1, ARHGEF12, CDC42, SCIN, ITGA4, ARPC2, MAPK1, BCAR1, NCKAP1, MYH14, PAK2, MYLK, PIK3R2, FGFR2, ARHGAP35, RAF1, ITGB3, MYH9, CSK, MAPK3, RAC2, VAV2, GSN, SSH3, DIAPH1, BAIAP2, WASL, CYFIP2",0.787812395596042,0.3585258894959,FALSE
+"H460","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.29623,-0.96,0.488,5747,0.607,"PRKAA1, GABARAPL2, PIK3C3, ATG12, PIK3R4, ATG7, ATG3, ATG4B",0.311580177997289,0.216811308924742,FALSE
+"H460","Input","KEGG_RENAL_CELL_CARCINOMA",-0.41953,-1.36,0.124,6398,0.446,"KRAS, NRAS, CRKL, RAC1, MAP2K2, PTPN11, PAK3, CUL2, MAP2K1, PIK3CA, PAK1, HGF, SOS1, PAK4, PIK3CB, AKT1, ARNT, GAB1, CDC42, MAPK1, PAK2, PIK3R2, RAF1, MAPK3, AKT2, TGFA",0.906578314837765,0.350665141287858,FALSE
+"H460","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",-0.23037,-0.744,0.799,8024,0.849,"MME",0.0974532206860086,0.0710923097560473,FALSE
+"H460","Input","KEGG_RETINOL_METABOLISM",-0.41015,-1.32,0.158,6676,0.448,"DHRS3, RDH11, ADH5, DGAT1, RDH10, ADH1C, DHRS9",0.801342913045577,0.348721986001856,FALSE
+"H460","Input","KEGG_RIBOFLAVIN_METABOLISM",-0.46756,-1.51,0.0872,8118,0.391,"ACP5, TYR",1.05948351506743,0.407823242604133,FALSE
+"H460","Input","KEGG_RIBOSOME",-0.54356,-1.76,0.0351,6007,0.645,"RPL36, RPL27, RPL31, RPS26, RPL18, RPL11, RPS7, RPL3, RPS3, RPS13, RPS5, RPS9, RPL23, RPL10, RPL15, RPL26, RPL37A, RPL32, RPL18A, RPL10A, RPL7, RPS18, RPL14, RPL21, RPS15A, RPL35, RPS4X, RPS19, RPL8, RPS6, RPS2, RPL37, RPL9, RPL30, RPS24, RPS16, RPS25, RPL13A, RPL17, RPL28, RPL29, RPL19, RPL23A, RPL34, RPL27A, RPL24, RSL24D1, RPL22, RPL7A, FAU, RPS11, RPL36A, RPL36AL, RPS27L, UBA52, RPS23, RPS10, RPL38",1.45469288353418,0.190440285364732,FALSE
+"H460","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.49258,-1.57,0.0744,7571,0.387,"TRAF6, IKBKB, RIPK1, MAPK14, RELA, TRAF3, IFIH1, MAPK13, ISG15, MAPK12, MAP3K1, CYLD",1.12842706445412,0.412289034981089,FALSE
+"H460","Input","KEGG_RNA_DEGRADATION",0.35517,1.15,0.267,2342,0.542,"HSPA9, HSPD1, EXOSC8, LSM4, DCP2, TENT4A, EXOSC1, LSM2, EXOSC4, EXOSC10, LSM8, EXOSC6, MPHOSPH6, DCPS, LSM3, EXOSC5, DCP1A, PNPT1, PARN, EXOSC7, WDR61, EXOSC9, CNOT2, LSM6",0.573488738635425,0.266000713461613,FALSE
+"H460","Input","KEGG_RNA_POLYMERASE",0.6689,2.19,0.00394,2035,0.0905,"POLR3H, POLR3K, POLR2H, POLR3D, POLR2C, POLR2L, POLR2D, POLR1E, POLR2E, POLR3GL, POLR3G, POLR3C, POLR2I, POLR3F, POLR2F, POLR2G",2.40450377817443,1.0433514207948,TRUE
+"H460","Input","KEGG_SELENOAMINO_ACID_METABOLISM",0.33732,1.1,0.328,116,0.582,"PAPSS2, GGT1",0.484126156288321,0.235077015350112,FALSE
+"H460","Input","KEGG_SMALL_CELL_LUNG_CANCER",0.2783,0.885,0.576,398,0.734,"FN1, LAMB1, PIK3R3, LAMA1, LAMC1, LAMA5, ITGAV, LAMB2",0.239577516576788,0.134303940083929,FALSE
+"H460","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",-0.2615,-0.852,0.618,8342,0.735,"VAMP8, YKT6, VAMP3",0.209011524911184,0.133712660915805,FALSE
+"H460","Input","KEGG_SPHINGOLIPID_METABOLISM",0.60432,1.94,0.0181,383,0.185,"GALC, PLPP3, GLA, ASAH1, ARSA",1.74232142513082,0.732828271596986,TRUE
+"H460","Input","KEGG_SPLICEOSOME",0.29516,0.951,0.459,2731,0.757,"PPIE, SNRPB2, SF3B4, LSM4, SRSF1, SNU13, LSM2, SNRPD3, SNRPF, HNRNPU, SRSF8, PHF5A, TRA2A, SNRPG, SF3B5, SRSF6, SRSF7, LSM8, SRSF5, PRPF18, SRSF9, PPIH, TXNL4A, RBM8A, SRSF3, LSM3, HNRNPA3, TCERG1, SRSF2, SRSF10, ISY1, NCBP2, TRA2B, RBM25, SF3A3, HNRNPK, RBMX, SNRPA, U2SURP, DDX5, SF3A1, SRSF4, LSM6, BCAS2, PRPF40A, ALYREF, SNRPB, PRPF4, RBM17, DHX8, CHERP, SNRNP70, SNRNP40, THOC3, DDX46",0.338187314462739,0.120904120499927,FALSE
+"H460","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.39267,-1.26,0.173,7080,0.432,"GYS1, PGM2, UGP2, MGAM, GPI, HK1, AGL, PGM2L1, PGM1",0.761953896871205,0.364516253185088,FALSE
+"H460","Input","KEGG_STEROID_BIOSYNTHESIS",-0.62399,-2,0.0114,6129,0.55,"CEL, LIPA, CYP51A1, LSS, NSDHL, SQLE, MSMO1, HSD17B7, SOAT2, FDFT1, DHCR24, TM7SF2, DHCR7",1.94309514866353,0.259637310505756,FALSE
+"H460","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.69483,2.26,0.00617,285,0.268,"CYP21A2, AKR1D1, CYP1B1, AKR1C3, AKR1C1",2.20971483596676,0.571865205971211,FALSE
+"H460","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.3127,1.01,0.384,1265,0.671,"C9, SNRPD3, C7",0.415668775632469,0.173277479831008,FALSE
+"H460","Input","KEGG_TASTE_TRANSDUCTION",0.53334,1.76,0.0397,2207,0.201,"CACNA1A, GNB1, GNB3, GNAS",1.40120949323689,0.696803942579511,TRUE
+"H460","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.66274,-2.12,0.00795,7922,0.608,"ACAT2, MVD, HMGCS2, MVK, FDPS, HMGCS1",2.09963287134353,0.216096420727265,FALSE
+"H460","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.28637,0.93,0.493,536,0.718,"FST, TGFB2, TGFBR1, E2F5, THBS3, SMAD2",0.30715308072277,0.1438755557577,FALSE
+"H460","Input","KEGG_THYROID_CANCER",-0.50513,-1.61,0.0475,6376,0.379,"CTNNB1, KRAS, NRAS, MAP2K2, RXRB, MAP2K1, RXRG, TFG, CDH1, TCF7L2, MAPK1, MAPK3, NCOA4",1.32330639037513,0.421360790031928,FALSE
+"H460","Input","KEGG_TIGHT_JUNCTION",-0.27612,-0.891,0.544,5842,0.688,"TJP3, PPP2R2B, CSNK2A1, CSNK2A2, PPP2R2A, MYL12A, PPP2CB, GNAI3, AKT3, PARD6G, MAP3K20, LLGL2, CTNNB1, KRAS, NRAS, RAB13, PPP2R1A, PPP2CA, HCLS1, CDK4, EPB41, RHOA, TJAP1, AKT1, MYH10, PRKCQ, CDC42, F11R, MYH14, MYH7B, CLDN7, MYH3, MYH9, CGN, PRKCD, AKT2, PRKCI, CTTN, MYH11, EPB41L1, CLDN3, CRB3, CLDN18",0.26440110030182,0.162411561764489,FALSE
+"H460","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.36332,-1.17,0.251,6925,0.467,"TBK1, MAP2K2, MAP2K1, PIK3CA, IRF3, PIK3CB, AKT1, TAB2, IRAK4, TRAF6, IKBKB, RIPK1, MAPK1, MAPK14, PIK3R2, RELA, MAPK3, TRAF3, STAT1, AKT2, MAPK13, MAP2K4, MAPK12",0.600326278518962,0.330683119433888,FALSE
+"H460","Input","KEGG_TRYPTOPHAN_METABOLISM",0.25244,0.805,0.681,789,0.802,"CYP1B1, KYNU, ECHS1",0.166852888087215,0.0958256317158365,FALSE
+"H460","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.40881,-1.28,0.172,7221,0.435,"PIK3CA, PIK3CB, HK1, IKBKB, MAPK1, PIK3R2, MAPK3, PKLR, PRKCD, PKM, IRS1",0.764471553092451,0.361510743045363,FALSE
+"H460","Input","KEGG_TYROSINE_METABOLISM",-0.52107,-1.69,0.0392,6759,0.382,"COMT, MIF, GOT1, ADH5, TYRP1, ADH1C, TRMT11, METTL2B, LCMT1, ALDH1A3, DCT, TYR",1.40671393297954,0.417936637088291,FALSE
+"H460","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.52938,-1.72,0.0416,6979,0.466,"MAP2K2, CDK4, PAK3, NFATC3, MAP2K1, RHOA, PIK3CA, PAK1, SOS1, PAK4, PIK3CB, AKT1, GSK3B, PRKCQ, IKBKB, CDC42, PPP3CA, NFAT5, MAPK1, PLCG1, PAK2, MAPK14, PIK3R2, RAF1, RELA, MAPK3, VAV2, PPP3CB, AKT2, PTPRC, MAPK13, PTPN6, MAPK12, NFATC2",1.38090666937326,0.33161408331,FALSE
+"H460","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.30709,-1.02,0.412,5542,0.553,"FBXO4, CUL4B, HERC2, HUWE1, FBXO2, UBE2D4, HERC4, SMURF1, CBL, UBE2N, CDC34, UBE2NL, UBE2K, UBA2, ANAPC4, UBA1, UBE2Q1, TRIM32, CBLB, UBE2L3, UBE4B, UBE2D2, NEDD4L, CUL3, CUL5, CUL1, DET1, UBE2O, CUL2, ITCH, CUL4A, UBE2E1, UBA6, SYVN1, PIAS4, FZR1, TRAF6, UBE2E2, WWP1, CDC23, TRIM37, CDC16, BTRC, KEAP1, SMURF2, UBE2C, UBE2L6, MAP3K1, PIAS2",0.385102783966865,0.257274868695302,FALSE
+"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.31571,1.04,0.384,1137,0.645,"PDHB, PDHA1",0.415668775632469,0.190440285364732,FALSE
+"H460","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.38241,1.21,0.212,1863,0.493,"ACAA2, HSD17B10, MCEE, HIBADH, ACADSB, ECHS1, OXCT1, ACADS, IVD, ACAT1, BCKDHB, PCCB, AUH, BCKDHA, DLD",0.673664139071249,0.30715308072277,FALSE
+"H460","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.28505,-0.923,0.524,6712,0.648,"PRKACB, PLCB3, ARHGEF1, MAP2K2, ROCK1, MAP2K1, RHOA, ROCK2, PRKCQ, ARHGEF12, MAPK1, MYLK, RAF1, MAPK3, PRKCD, MYH11",0.280668713016273,0.188424994129407,FALSE
+"H460","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.42696,-1.39,0.118,5663,0.462,"ARHGDIA, RAB5B, NSF, DCTN1, DYNC1LI2, RAB5A, DYNLL1, PRKACB, DYNC1LI1, RAB11A, VAMP2, DYNLL2, ARHGDIB, DYNC1H1, RAB5C, DYNC2H1, CREB3L1",0.928117992693875,0.335358024443874,FALSE
+"H460","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.5541,-1.76,0.0257,6979,0.645,"MAP2K2, NFATC3, MAP2K1, PIK3CA, PTK2, PIK3CB, AKT1, MAPKAPK2, PXN, CDC42, PPP3CA, NFAT5, PLCG2, MAPK1, PLCG1, MAPK14, PIK3R2, RAF1, MAPK3, RAC2, HSPB1, PPP3CB, AKT2, MAPK13, MAPK12, NFATC2",1.59006687666871,0.190440285364732,FALSE
+"H460","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",0.22788,0.74,0.817,2778,0.863,"TJP1, TCIRG1, PRKCB, ATP6V1F, SLC12A2, PDIA4, ACTG1, ATP6AP1, GNAS, ATP6V1E1, ACTB, ATP6V0C, ATP6V1G1, ATP6V1B2, ADCY9",0.0877779434675845,0.0639892042847904,FALSE
+"H460","Input","KEGG_VIRAL_MYOCARDITIS",-0.3596,-1.16,0.248,6642,0.474,"ICAM1, RAC1, ABL1, EIF4G2, MYH10, EIF4G1, MYH14, MYH7B, MYH3, MYH9, RAC2, MYH11, ABL2",0.605548319173784,0.324221658325915,FALSE
+"H460","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.26673,-0.841,0.646,5901,0.747,"CSNK2A1, CSNK2A2, MAP3K7, SMAD3, PPP2CB, CACYBP, FZD7, CSNK1E, CTNNB1, PPP2R1A, PPP2CA, PRKACB, RAC1, PLCB3, DAAM1, CUL1, ROCK1, NFATC3, RHOA, ROCK2, PPP2R5C, GSK3B, DVL3, PPP3CA, NFAT5, TCF7L2, PPP2R5B, BTRC, CSNK1A1, NLK, PPP2R5A, PPP2R5E, RAC2, PPP3CB, PPP2R5D, NFATC2",0.189767482004916,0.126679398184601,FALSE
+"H520","Input","KEGG_ABC_TRANSPORTERS",-0.288,-0.863,0.62,6792,0.695,"ABCA2, ABCD1, ABCC3, ABCA12, ABCG2, ABCA1, ABCB8",0.207608310501746,0.158015195409886,FALSE
+"H520","Input","KEGG_ACUTE_MYELOID_LEUKEMIA",-0.3015,-0.893,0.562,5328,0.671,"ARAF, RELA, AKT3, STAT3, GRB2, BRAF, STAT5A, PIK3CB, NFKB1, AKT1, PIK3R1, PML, CHUK, MAPK3, MAPK1, PIK3R3, IKBKG, SOS1, CCND1, IKBKB",0.250263684430939,0.173277479831008,FALSE
+"H520","Input","KEGG_ADHERENS_JUNCTION",-0.43395,-1.33,0.148,6625,0.386,"WAS, MAPK3, NECTIN4, RHOA, MAPK1, ACTN2, PARD3, MET, ERBB2, ACTN1, CDH1, MAP3K7, EGFR, NECTIN2, RAC3, VCL, BAIAP2, PTPRJ, TGFBR2, IQGAP1, IGF1R, RAC2",0.829738284605043,0.413412695328245,FALSE
+"H520","Input","KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY",-0.38133,-1.13,0.304,5343,0.471,"PRKAB1, RELA, AKT3, PRKAB2, STAT3, NFKB1, NFKBIB, AKT1, TRAF2, CHUK, TRADD, IRS2, IKBKG, ACSL4, IRS1, IKBKB, PRKCQ, RXRG",0.517126416391246,0.326979092871104,FALSE
+"H520","Input","KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",0.37669,1.18,0.244,282,0.434,"GLUD2, ASS1, GPT2, GOT2",0.612610173661271,0.362510270487489,FALSE
+"H520","Input","KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION",-0.42171,-1.27,0.184,6303,0.423,"PIK3R1, PRKCA, MAPK3, MAPK1, IRS2, PIK3R3, SLC9A3R2, NEDD4L, PRKCB, IRS1, PRKCG",0.735182176990464,0.373659632624958,FALSE
+"H520","Input","KEGG_ALZHEIMERS_DISEASE",0.32205,0.991,0.434,2586,0.579,"MME, ITPR1, SDHD, ATP5MC2, NDUFA6, ATP5F1C, GRIN1, NDUFS7, ERN1, UQCRH, BAD, CASP7, ATP5PO, PSEN2, ATP5PB, ADAM10, ATP5F1B, ATP5F1E, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, NDUFA4, NDUFB7, HSD17B10, SDHC, NDUFB4, NDUFS8, NDUFS6, GSK3B, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP5PD, NDUFA10, CALML3, NDUFB8, NDUFV1, SDHB, NDUFS4, NDUFS3, COX4I1, ATF6, NDUFAB1, NDUFS1, PSEN1, ATP2A2, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, UQCRQ, SNCA, NCSTN",0.362510270487489,0.237321436272564,FALSE
+"H520","Input","KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",0.61161,1.99,0.0219,1050,0.235,"WARS2, RARS2, EARS2, CARS2, LARS2, NARS2, MTFMT",1.65955588515988,0.628932137728264,TRUE
+"H520","Input","KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM",-0.41469,-1.23,0.21,6115,0.422,"UGP2, AMDHD2, HEXB, GNPNAT1, GFPT2, CMAS, GMPPB, GMPPA, NAGK, GFPT1, GALK1, UAP1, UGDH, NPL, PGM1, GALE",0.677780705266081,0.374687549038326,FALSE
+"H520","Input","KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS",0.24265,0.752,0.814,982,0.875,"MAP2K6, SOD1, NEFL, GRIN1, DERL1, BAD, BCL2L1",0.0893755951107988,0.0579919469776868,FALSE
+"H520","Input","KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION",-0.52673,-1.6,0.0514,6404,0.496,"TAP2, HSP90AB1, TAPBP, CALR, HSPA6, HSP90AA1, PSME3, CTSL, CD74, LGMN, B2M, CTSB, HSPA2, HSPA1L, CTSS",1.28903688100472,0.304518323509803,FALSE
+"H520","Input","KEGG_APOPTOSIS",-0.45471,-1.34,0.155,5725,0.403,"DFFB, PIK3CB, PRKAR2B, PPP3CB, NFKB1, PPP3CA, IRAK4, RIPK1, AKT1, PIK3R1, PRKACA, DFFA, TRAF2, CASP8, FADD, MYD88, CHUK, CASP6, TRADD, IL1RAP, BIRC2, PIK3R3, FAS, IKBKG, BID, ENDOD1, APAF1, CAPN1, TP53, CAPN2, PPP3R1, IKBKB, TNFRSF10D",0.809668301829709,0.39469495385889,FALSE
+"H520","Input","KEGG_ARACHIDONIC_ACID_METABOLISM",-0.52063,-1.56,0.0697,7424,0.393,"PLA2G4A, CBR3, ALOX5, GGT1, EPHX2, PTGS2, PTGES",1.15676722190199,0.405607449624573,FALSE
+"H520","Input","KEGG_ARGININE_AND_PROLINE_METABOLISM",0.43402,1.38,0.115,539,0.278,"MAOB, ALDH2, GLUD2, ASS1, GATM, MAOA, GOT2, ALDH3A2, PYCR1, SMS, CKB",0.939302159646388,0.555955204081924,FALSE
+"H520","Input","KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC",-0.41071,-1.22,0.217,6698,0.406,"ITGB3, ACTN2, ACTN1, ITGB5, ITGA2B, DES, ITGB1, ITGAV, ITGA1, LMNA, GJA1, ITGA3, ITGA5, ITGB6",0.66354026615147,0.391473966422806,FALSE
+"H520","Input","KEGG_ASCORBATE_AND_ALDARATE_METABOLISM",0.60321,1.9,0.0178,1756,0.229,"ALDH2, ALDH3A2, ALDH7A1, ALDH9A1, ALDH1B1",1.74957999769111,0.640164517660112,TRUE
+"H520","Input","KEGG_AXON_GUIDANCE",-0.47552,-1.46,0.0898,6559,0.369,"ROCK2, ABLIM1, MAPK3, ABL1, SRGAP1, RHOA, MAPK1, LIMK1, MET, ROCK1, SEMA4B, EPHA6, NRP1, ABLIM3, SRGAP2, SRGAP3, SLIT2, PLXNB2, EFNB2, CFL2, ITGB1, RAC3, EFNA5, L1CAM, EPHA2, PPP3R1, EFNB1, EPHB2, EFNA1, RAC2, NTN4, SEMA3C",1.0467236633327,0.43297363384094,FALSE
+"H520","Input","KEGG_BASAL_CELL_CARCINOMA",0.48127,1.5,0.0968,1560,0.308,"FZD1, CTNNB1, TCF7L1, TCF7L2, GSK3B",1.01412464269161,0.511449283499556,FALSE
+"H520","Input","KEGG_BASAL_TRANSCRIPTION_FACTORS",0.27489,0.864,0.589,6007,0.709,"TBPL1, GTF2H3, GTF2H4, GTF2H2, TAF9B, TAF2, TAF6L, GTF2H1, TAF12, GTF2A2, GTF2F1, GTF2I, TAF1, TAF5L, GTF2B, GTF2IRD1, TAF9, TBP, GTF2F2, TAF4, TAF7, TAF6, GTF2E2, TAF5, GTF2A1, TAF10, GTF2E1",0.229884705212898,0.149353764816933,FALSE
+"H520","Input","KEGG_BASE_EXCISION_REPAIR",-0.29101,-0.863,0.616,6072,0.695,"HMGB1, XRCC1, POLD1, POLD4, POLE3, POLE2, LIG1, POLE, PCNA, PARP4",0.210419287835575,0.158015195409886,FALSE
+"H520","Input","KEGG_BETA_ALANINE_METABOLISM",0.48146,1.49,0.101,2076,0.301,"ALDH2, HIBCH, ALDH3A2, MLYCD, SMS, ALDH7A1, ALDH9A1, ALDH1B1, HADHA, ECHS1",0.995678626217357,0.521433504406157,FALSE
+"H520","Input","KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS",0.40583,1.3,0.171,651,0.32,"FADS2, PECR, HSD17B12, HACD2, FADS1",0.767003889607846,0.494850021680094,FALSE
+"H520","Input","KEGG_BLADDER_CANCER",-0.58201,-1.75,0.0327,6638,0.508,"TYMP, MAPK3, MAPK1, ERBB2, DAPK1, CDK4, CDH1, CCND1, EGFR, TP53, DAPK3, RPS6KA5, CDKN2A",1.48545224733971,0.294136287716081,FALSE
+"H520","Input","KEGG_BUTANOATE_METABOLISM",0.29553,0.933,0.486,2076,0.64,"ALDH2, ALDH3A2, BDH1, ALDH5A1, ALDH7A1, ALDH9A1, ALDH1B1, OXCT1, HADH, HADHA, PDHA1, L2HGDH, ECHS1",0.313363730737707,0.193820026016113,FALSE
+"H520","Input","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.45009,-1.36,0.139,5683,0.386,"GRB2, PTPN6, PIK3CB, PPP3CB, NFKB1, PPP3CA, NFKBIB, AKT1, PIK3R1, NFATC2, BCL10, CHUK, MAPK3, MAPK1, CD22, PIK3R3, IKBKG, SOS1, PRKCB, VAV2, RAC3, PPP3R1, PLCG2, IKBKB, PIK3AP1, CARD11, RAC2",0.856985199745905,0.413412695328245,FALSE
+"H520","Input","KEGG_CALCIUM_SIGNALING_PATHWAY",-0.32157,-0.952,0.458,6959,0.61,"ERBB2, PLCB3, ATP2A3, ATP2B2, ATP2B4, PLCD3, EGFR, PRKCB, ERBB4, CACNA1A, PPP3R1, PLCG2, TNNC1, ITPR3, ITPKA, ADCY9, PRKCG, ERBB3",0.339134521996131,0.214670164989233,FALSE
+"H520","Input","KEGG_CARDIAC_MUSCLE_CONTRACTION",-0.2214,-0.665,0.884,7023,0.921,"TPM1, TPM2, TPM3, TNNC1, TPM4, MYL3",0.0535477349869269,0.0357403698031511,FALSE
+"H520","Input","KEGG_CELL_ADHESION_MOLECULES_CAMS",-0.37417,-1.1,0.288,6875,0.489,"CD40, CD22, CDH15, CDH3, CLDN11, ICAM2, CDH1, CD58, ITGB1, NECTIN2, L1CAM, ITGAV, CDH5, CLDN4, ICAM1, ITGB2, CD274, SDC4, CLDN6, CD99",0.540607512240769,0.31069114087638,FALSE
+"H520","Input","KEGG_CELL_CYCLE",-0.28827,-0.855,0.645,6390,0.701,"MCM4, TTK, MCM7, MCM3, YWHAZ, ABL1, PLK1, CHEK2, CDC45, MCM6, CCNA2, YWHAE, YWHAQ, CDK4, YWHAG, FZR1, YWHAH, YWHAB, PCNA, CCND1, TP53, CCNB1, TGFB1, CDKN2A",0.190440285364732,0.154281982033341,FALSE
+"H520","Input","KEGG_CHEMOKINE_SIGNALING_PATHWAY",-0.34986,-1.03,0.397,5640,0.529,"STAT3, PLCB4, GRB2, BRAF, GNB2, PREX1, PIK3CB, CRK, CCL13, NFKB1, NFKBIB, AKT1, PIK3R1, PRKACA, GRK2, STAT2, DOCK2, WASL, BCAR1, ROCK2, WAS, CHUK, MAPK3, GNG4, RHOA, MAPK1, PARD3, SHC1, ROCK1, PLCB3, ARRB2, PIK3R3, IKBKG, SOS1, STAT1, PXN, CXCL5, CRKL, PRKCB, VAV2, PRKCD, IKBKB, ADCY9, GNG12, ARRB1, RAC2",0.401209493236885,0.276544327964814,FALSE
+"H520","Input","KEGG_CHRONIC_MYELOID_LEUKEMIA",-0.3625,-1.08,0.348,5683,0.505,"GRB2, BRAF, STAT5A, CTBP2, PIK3CB, CRK, NFKB1, AKT1, PIK3R1, BCR, CHUK, MAPK3, ABL1, MAPK1, SHC1, PIK3R3, IKBKG, SOS1, CDK4, CCND1, CRKL, TP53, TGFB1, TGFBR2, IKBKB, CDKN2A",0.458420756053419,0.296708621881339,FALSE
+"H520","Input","KEGG_CITRATE_CYCLE_TCA_CYCLE",0.29783,0.944,0.479,2927,0.634,"SDHD, SUCLA2, PCK2, SDHC, PDHA1, CS, SDHB, DLAT, IDH3B, SUCLG1, IDH3G, PDHB, SDHA, IDH1, IDH3A",0.319664486585437,0.197910742118267,FALSE
+"H520","Input","KEGG_COLORECTAL_CANCER",-0.29811,-0.896,0.562,6266,0.673,"AKT1, PIK3R1, MSH2, MAPK3, MLH1, RHOA, MAPK1, BIRC5, PIK3R3, CCND1, TP53, RAC3, TGFB1, TGFBR2, RAC2",0.250263684430939,0.171984935776023,FALSE
+"H520","Input","KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",-0.44316,-1.33,0.142,7300,0.386,"PLG, MBL2, F8, CD59, C3, CD55, A2M, PLAU, CFB, SERPINE1, CFI, SERPINA1, TFPI",0.847711655616944,0.413412695328245,FALSE
+"H520","Input","KEGG_CYSTEINE_AND_METHIONINE_METABOLISM",0.22395,0.707,0.821,1687,0.874,"GOT2, DNMT3B, SMS, DNMT3A, CBS, MAT1A, APIP, MAT2A",0.0856568428805592,0.058488567365597,FALSE
+"H520","Input","KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION",-0.37407,-1.11,0.294,6842,0.48,"MET, CD40, IL1RAP, TNFRSF21, FAS, IFNGR1, HGF, ACVR1, CXCL5, EGFR, IL6ST, TGFB1, TGFBR2, IL6, EPO, OSMR, LTBR, IL18, TNFRSF10D",0.531652669587843,0.318758762624413,FALSE
+"H520","Input","KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY",-0.53277,-1.58,0.0568,5897,0.406,"TBK1, NFKB1, NFKBIB, TREX1, RIPK1, CHUK, IKBKG, DDX58, IRF3, IKBKB, IL6, ZBP1, IL18",1.24565166428898,0.391473966422806,FALSE
+"H520","Input","KEGG_DILATED_CARDIOMYOPATHY",-0.53114,-1.59,0.0549,7023,0.477,"TPM1, TPM2, ITGB5, ITGA2B, DES, ITGB1, TPM3, TGFB1, ITGAV, ITGA1, LMNA, TNNC1, TPM4, MYL3, ADCY9, ITGA3, ITGA5, ITGB6",1.26042765554991,0.321481620959886,FALSE
+"H520","Input","KEGG_DNA_REPLICATION",-0.53333,-1.58,0.0569,4986,0.406,"POLA1, RFC5, RNASEH1, POLD2, RFC2, RFC4, POLD3, MCM5, POLA2, RPA3, PRIM1, POLD1, MCM4, MCM7, MCM3, PRIM2, POLD4, POLE3, RNASEH2A, RNASEH2C, POLE2, MCM6, LIG1, POLE, PCNA",1.24488773360493,0.391473966422806,FALSE
+"H520","Input","KEGG_DORSO_VENTRAL_AXIS_FORMATION",-0.6349,-1.88,0.0176,6679,0.408,"MAPK3, MAPK1, NOTCH2, SOS1, EGFR, NOTCH3, ETV6, ETS1, ETS2",1.75448733218585,0.38933983691012,FALSE
+"H520","Input","KEGG_DRUG_METABOLISM_CYTOCHROME_P450",0.57053,1.82,0.0305,204,0.205,"MAOB, ALDH3A1, GSTA4, GSTM2, GSTA5, MAOA",1.51570016065321,0.688246138944246,TRUE
+"H520","Input","KEGG_DRUG_METABOLISM_OTHER_ENZYMES",-0.48686,-1.42,0.122,7911,0.384,"DPYD, UPP1, TPMT, CDA",0.913640169325252,0.415668775632469,FALSE
+"H520","Input","KEGG_ECM_RECEPTOR_INTERACTION",-0.4673,-1.39,0.119,6996,0.377,"HMMR, ITGB5, COL4A1, ITGA2B, ITGB1, LAMA3, LAMA4, COL6A1, ITGAV, ITGA1, LAMB3, TNC, LAMB1, COL5A2, ITGA3, SDC4, ITGA5, ITGB6",0.924453038607469,0.423658649794207,FALSE
+"H520","Input","KEGG_ENDOCYTOSIS",-0.45783,-1.4,0.123,6062,0.386,"RUFY1, LDLR, STAM2, PLD2, SNF8, SMURF2, VPS36, GIT1, CHMP2A, CLTB, VPS37A, GRK2, PRKCI, SH3GLB1, CHMP4C, EHD3, RAB22A, ITCH, HGS, CHMP5, EPN3, HSPA6, PDCD6IP, ARFGAP1, ARFGAP3, RNF41, RAB11FIP4, STAM, PARD3, MET, SH3GLB2, CHMP4A, CHMP4B, ARRB2, RABEP1, DNAJC6, ARF6, EGFR, NEDD4L, ERBB4, EPS15, EPN1, DAB2, CLTA, EHD2, SH3KBP1, EHD1, PARD6B, RAB31, HSPA2, PARD6G, RAB11FIP5, ARRB1, IGF1R, ERBB3, HSPA1L",0.910094888560602,0.413412695328245,FALSE
+"H520","Input","KEGG_ENDOMETRIAL_CANCER",-0.34435,-1.02,0.388,5533,0.532,"AKT3, CTNNA1, GRB2, BRAF, PIK3CB, AKT1, PIK3R1, MAPK3, MLH1, MAPK1, ERBB2, ILK, PIK3R3, SOS1, CDH1, CCND1, EGFR, TP53",0.411168274405793,0.274088367704952,FALSE
+"H520","Input","KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION",0.18133,0.567,0.975,1025,0.99,"PTPRZ1, JAM3, F11R, ATP6V0A1, ADAM10, ATP6V0A2",0.0109953843014632,0.00436480540245009,FALSE
+"H520","Input","KEGG_ERBB_SIGNALING_PATHWAY",-0.40815,-1.22,0.194,5277,0.406,"NCK2, ARAF, HBEGF, AKT3, PAK2, GRB2, BRAF, STAT5A, PIK3CB, CRK, PLCG1, ABL2, CAMK2D, AREG, AKT1, PIK3R1, PRKCA, MAPK3, ABL1, MAPK1, SHC1, ERBB2, PIK3R3, SOS1, EGFR, CRKL, PRKCB, ERBB4, PLCG2, PRKCG, ERBB3",0.712198270069774,0.391473966422806,FALSE
+"H520","Input","KEGG_ETHER_LIPID_METABOLISM",-0.34683,-1.05,0.364,5362,0.524,"PAFAH1B1, PLD1, PLA2G12A, LPCAT1, PAFAH1B2, PLD2, PAFAH1B3, PLPP3, PLA2G4A",0.438898616350944,0.280668713016273,FALSE
+"H520","Input","KEGG_FATTY_ACID_METABOLISM",0.46753,1.48,0.0943,2076,0.268,"ACAA2, ALDH2, ECI1, ALDH3A2, ACSL5, ALDH7A1, ALDH9A1, ACOX1, CPT2, ECI2, ALDH1B1, CPT1C, HADH, HADHA, GCDH, CPT1A, ECHS1",1.02548830726267,0.571865205971211,FALSE
+"H520","Input","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",-0.31983,-0.978,0.45,6266,0.573,"AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, PIK3R3, SOS1, PLA2G4A, PRKCB, VAV2, RAC3, PLCG2, PRKCD, RAC2",0.346787486224656,0.24184537803261,FALSE
+"H520","Input","KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS",-0.4002,-1.23,0.19,5775,0.422,"PIK3CB, CRK, ARPC3, CFL1, ARPC2, PLCG1, PLD2, AKT1, PIK3R1, PRKCA, DOCK2, WASL, MARCKS, WAS, MAPK3, MAPK1, PLPP3, LIMK1, PIK3R3, ARPC1B, ARPC5, PLA2G4A, CFL2, ARF6, CRKL, PRKCB, GSN, VAV2, SCIN, PLCG2, PRKCD, VASP, PRKCG, RAC2, AMPH",0.721246399047171,0.374687549038326,FALSE
+"H520","Input","KEGG_FOCAL_ADHESION",-0.56261,-1.73,0.0262,6499,0.43,"BCAR1, FLT4, ROCK2, COL6A3, TLN1, MAPK3, ITGB3, DOCK1, RHOA, MAPK1, PARVB, ACTN2, MET, SHC1, ERBB2, ACTN1, ROCK1, ILK, BIRC2, PIK3R3, ARHGAP35, ITGB5, COL4A1, HGF, SOS1, CAV1, ITGA2B, PXN, CCND1, ITGB1, PPP1R12A, MYL12A, EGFR, CRKL, PRKCB, LAMA3, LAMA4, CAPN2, VAV2, RAC3, COL6A1, VCL, ITGAV, ITGA1, FLNA, LAMB3, TNC, PARVA, LAMB1, MYL9, COL5A2, FLNC, VASP, PRKCG, ITGA3, IGF1R, ZYX, CAV2, FLNB, ITGA5, RAC2, ITGB6",1.58169870868025,0.366531544420413,FALSE
+"H520","Input","KEGG_FOLATE_BIOSYNTHESIS",0.47477,1.46,0.0902,75,0.272,"GGH",1.04479346245806,0.565431095965801,FALSE
+"H520","Input","KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM",-0.35974,-1.07,0.344,5729,0.513,"ALDOC, AKR1B1, PMM1, PHPT1, TPI1, FBP2, MTMR1, PFKL, MTMR6, GMPPB, GMPPA, MTMR7, ALDOA, PFKFB2, PFKP",0.46344155742847,0.289882634888184,FALSE
+"H520","Input","KEGG_GALACTOSE_METABOLISM",-0.41829,-1.24,0.205,7354,0.44,"GALK1, B4GALT1, PGM1, GALE, PFKP",0.688246138944246,0.356547323513813,FALSE
+"H520","Input","KEGG_GAP_JUNCTION",-0.33642,-1.02,0.412,6679,0.532,"MAPK3, MAPK1, PLCB3, TUBB1, TUBB3, SOS1, EGFR, PRKCB, TUBB4B, GJA1, ITPR3, ADCY9, PRKCG, TUBA4A",0.385102783966865,0.274088367704952,FALSE
+"H520","Input","KEGG_GLIOMA",-0.51035,-1.55,0.0723,5683,0.337,"GRB2, BRAF, PIK3CB, PLCG1, CAMK2D, AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, SHC1, PIK3R3, SOS1, CDK4, CCND1, EGFR, PRKCB, TP53, PLCG2, CDKN2A, PRKCG, IGF1R",1.14086170270547,0.472370099128661,FALSE
+"H520","Input","KEGG_GLUTATHIONE_METABOLISM",0.315,1.02,0.366,725,0.556,"GSTA4, GSTM2, GSTA5, PGD, SMS, GCLC, GSTZ1",0.436518914605589,0.254925208417942,FALSE
+"H520","Input","KEGG_GLYCEROLIPID_METABOLISM",0.2907,0.897,0.52,1380,0.689,"ALDH2, AKR1A1, AGPAT4, GK, ALDH3A2, PLPP2, PLPP1, ALDH7A1, ALDH9A1, DGKE",0.283996656365201,0.161780778092374,FALSE
+"H520","Input","KEGG_GLYCEROPHOSPHOLIPID_METABOLISM",-0.30194,-0.896,0.541,5789,0.673,"PLA2G12A, ETNK1, LPCAT1, CDS2, DGKZ, PLD2, GPAT3, LPGAT1, LYPLA2, GPAT4, MBOAT7, CDS1, PLPP3, AGPAT3, GPD2, DGKH, PCYT2, AGPAT2, PLA2G4A, GPD1L, PEMT, DGKA",0.266802734893431,0.171984935776023,FALSE
+"H520","Input","KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM",0.59227,1.82,0.0214,384,0.205,"PIPOX, MAOB, GLDC, GATM, MAOA, PHGDH, CHDH",1.66958622665081,0.688246138944246,TRUE
+"H520","Input","KEGG_GLYCOLYSIS_GLUCONEOGENESIS",-0.26249,-0.789,0.735,6205,0.769,"TPI1, FBP2, GAPDH, PKLR, ENO1, PFKL, LDHA, DLD, PGAM1, PGAM4, ENO2, ALDOA, ALDH1A3, LDHB, PGM1, ACSS2, PFKP, GALM, ALDH3B1",0.133712660915805,0.114073660198569,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE",-0.37979,-1.14,0.261,8200,0.469,"CHST12",0.583359492661719,0.328827157284917,FALSE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE",0.59244,1.81,0.0446,2580,0.193,"EXT2, B3GAT3, B4GALT7, HS2ST1, XYLT2, EXT1, EXTL3, HS3ST1",1.35066514128786,0.714442690992226,TRUE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE",-0.7729,-2.3,0.00653,7363,0.0953,"ST3GAL1, B4GAT1, B3GNT2, B4GALT1",2.18508681872493,1.02090709936167,TRUE
+"H520","Input","KEGG_GLYCOSAMINOGLYCAN_DEGRADATION",-0.18809,-0.561,0.967,5019,0.992,"HGSNAT, GLB1, HPSE, GALNS, GUSB, GNS, HEXB, IDS, SGSH",0.0145735259169983,0.00348832784582135,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES",0.23468,0.712,0.804,2188,0.896,"B4GALNT1, SLC33A1, HEXA",0.0947439512515487,0.0476919903378748,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",-0.64224,-1.95,0.00632,6425,0.372,"NAGA, HEXB, ST3GAL1, B3GALT5",2.19928292171761,0.429457060118102,FALSE
+"H520","Input","KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES",-0.82526,-2.43,0,7401,0.0584,"B3GNT3, B4GAT1, B3GNT2, FUT3, B4GALT1, B3GALT5",Inf,1.2335871528876,TRUE
+"H520","Input","KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS",0.45217,1.41,0.112,1925,0.282,"PIGX, PIGM, PIGA, PIGO, PGAP1, PIGQ",0.950781977329818,0.549750891680639,FALSE
+"H520","Input","KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM",0.36436,1.16,0.243,1923,0.437,"MTHFD2, GRHPR, MTHFD1L, CS",0.614393726401688,0.359518563029578,FALSE
+"H520","Input","KEGG_GNRH_SIGNALING_PATHWAY",-0.28103,-0.828,0.665,6200,0.726,"PLD2, CAMK2D, PRKACA, PRKCA, MAPK3, MAPK1, PLCB3, SOS1, PLA2G4A, EGFR, PRKCB, MMP14, PRKCD, ITPR3, ADCY9",0.177178354696895,0.139063379299906,FALSE
+"H520","Input","KEGG_HEDGEHOG_SIGNALING_PATHWAY",-0.36966,-1.12,0.275,7659,0.473,"LRP2, CSNK1A1",0.560667306169737,0.325138859262188,FALSE
+"H520","Input","KEGG_HEMATOPOIETIC_CELL_LINEAGE",-0.4953,-1.5,0.0792,7231,0.374,"ITGA2B, CD59, CD55, CD9, ITGA1, ANPEP, IL6, CD33, ITGA3, EPO, ITGA5",1.10127481841051,0.42712839779952,FALSE
+"H520","Input","KEGG_HISTIDINE_METABOLISM",0.55534,1.71,0.0353,694,0.213,"MAOB, ALDH3A1, ALDH2, MAOA, ALDH3A2, TRMT11",1.45222529461218,0.671620396561262,TRUE
+"H520","Input","KEGG_HOMOLOGOUS_RECOMBINATION",-0.16828,-0.502,0.989,6290,1,"RPA3, POLD1, BLM, POLD4, TOP3B",0.0048037084028206,0,FALSE
+"H520","Input","KEGG_HUNTINGTONS_DISEASE",0.32765,1.03,0.371,2479,0.553,"SLC25A4, ITPR1, SOD1, SDHD, ATP5MC2, NDUFA6, TFAM, ATP5F1C, GRIN1, NDUFS7, UQCRH, VDAC1, ATP5PO, ATP5PB, ATP5F1B, ATP5F1E, VDAC3, ATP5F1A, NDUFA9, CYC1, TBPL1, NDUFB3, CREB1, NDUFA7, NDUFA4, NDUFB7, SLC25A31, SDHC, NDUFB4, NDUFS8, POLR2A, SLC25A5, NDUFS6, NDUFS5, NDUFC2, UQCRC2, SIN3A, UQCRFS1, ATP5PD, NDUFA10, NDUFB8, SLC25A6, POLR2B, NDUFV1, POLR2H, VDAC2, SDHB, NDUFS4, NDUFS3, COX4I1, SOD2, NDUFAB1, NDUFS1, HDAC2, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, POLR2K, NDUFA3",0.430626090384954,0.257274868695302,FALSE
+"H520","Input","KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM",-0.56424,-1.68,0.0524,7023,0.47,"TPM1, TPM2, ITGB5, ITGA2B, DES, ITGB1, TPM3, TGFB1, ITGAV, ITGA1, LMNA, TNNC1, TPM4, IL6, MYL3, ACE, ITGA3, ITGA5, ITGB6",1.28066871301627,0.327902142064283,FALSE
+"H520","Input","KEGG_INOSITOL_PHOSPHATE_METABOLISM",-0.42131,-1.28,0.163,6626,0.427,"PIP4K2C, SYNJ2, PLCB3, INPP1, PLCD3, PLCG2, ITPK1, IMPA2, ITPKA, INPP4B, ISYNA1",0.787812395596042,0.369572124974976,FALSE
+"H520","Input","KEGG_INSULIN_SIGNALING_PATHWAY",-0.22647,-0.687,0.882,5533,0.902,"AKT3, PRKAB2, PPP1CA, GRB2, BRAF, PIK3CB, PRKAR2B, CRK, PTPN1, EXOC7, FBP2, AKT1, PIK3R1, PRKACA, PKLR, PRKCI, MAPK3, MAPK1, TSC1, SHC1, IRS2, PIK3R3, FASN, SOS1, RHEB, CRKL, PPP1R3D, PYGB, TRIP10, IRS1, IKBKB",0.0545314148681803,0.0447934624580583,FALSE
+"H520","Input","KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION",-0.74123,-2.21,0,6875,0.113,"CD40, TGFB1, IL6, LTBR",Inf,0.94692155651658,TRUE
+"H520","Input","KEGG_JAK_STAT_SIGNALING_PATHWAY",-0.4681,-1.39,0.134,5640,0.377,"STAT3, GRB2, STAT5A, PTPN6, PIK3CB, STAM2, IFNAR1, JAK1, AKT1, PIK3R1, STAT2, OSM, STAM, PIK3R3, IFNGR1, SOS1, STAT1, CCND1, IRF9, IL6ST, IL6, STAT6, EPO, OSMR",0.872895201635192,0.423658649794207,FALSE
+"H520","Input","KEGG_LEISHMANIA_INFECTION",-0.49863,-1.52,0.0859,5911,0.361,"NFKB1, NFKBIB, IRAK4, JAK1, TAB1, MYD88, MAPK3, MAPK1, CYBA, IFNGR1, STAT1, TAB2, ITGB1, C3, MAP3K7, PRKCB, TGFB1, PTGS2, ITGB2",1.06600683616876,0.442492798094342,FALSE
+"H520","Input","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",-0.54327,-1.65,0.0548,6788,0.484,"RHOA, ACTN2, ACTN1, ROCK1, CYBA, PIK3R3, ARHGAP35, CLDN11, PXN, ITGB1, MYL12A, PRKCB, VAV2, VCL, PLCG2, EZR, MYL9, CDH5, VASP, CLDN4, PRKCG, ICAM1, ITGB2, SIPA1, RAC2, CLDN6, CD99",1.26121944151563,0.315154638355588,FALSE
+"H520","Input","KEGG_LIMONENE_AND_PINENE_DEGRADATION",0.68026,2.19,0.00535,2450,0.184,"ALDH2, ALDH3A2, ALDH7A1, ALDH9A1, ALDH1B1, HADHA, ECHS1, YOD1",2.27164621797877,0.735182176990464,TRUE
+"H520","Input","KEGG_LONG_TERM_DEPRESSION",-0.32741,-1.01,0.407,5660,0.534,"PLCB4, BRAF, PPP2CB, PLA2G12A, PPP2R1A, PRKCA, MAPK3, MAPK1, PLCB3, PLA2G4A, PRKCB, CACNA1A, ITPR3, PRKCG, IGF1R",0.39040559077478,0.272458742971444,FALSE
+"H520","Input","KEGG_LONG_TERM_POTENTIATION",-0.34625,-1.04,0.364,5643,0.526,"PPP1CA, PLCB4, BRAF, PPP3CB, PPP3CA, RPS6KA6, RPS6KA2, CAMK2D, PRKACA, PRKCA, MAPK3, MAPK1, PLCB3, PPP1R12A, PRKCB, RPS6KA1, PPP3R1, ITPR3, PRKCG",0.438898616350944,0.279014255846261,FALSE
+"H520","Input","KEGG_LYSINE_DEGRADATION",0.4799,1.5,0.108,2201,0.308,"PIPOX, ALDH2, AASS, ALDH3A2, AADAT, NSD3, NSD2, NSD1, ALDH7A1, ALDH9A1, ALDH1B1, HADH, HADHA, GCDH, ECHS1, SETD1A, DOT1L",0.96657624451305,0.511449283499556,FALSE
+"H520","Input","KEGG_LYSOSOME",-0.27317,-0.814,0.68,5930,0.743,"AP3M2, CTSC, GNS, AP3M1, AP1S3, CTSZ, CLTB, NAGA, HEXB, GGA1, AP3B1, IDS, AP1S1, AP1B1, ABCA2, TPP1, FUCA1, M6PR, CTSL, NPC2, GGA3, LGMN, CTSA, PSAPL1, CTSV, SGSH, CLTA, TCIRG1, ATP6V0A4, CTSB, CTSS, CTSH, LAPTM4A",0.167491087293764,0.129011186239425,FALSE
+"H520","Input","KEGG_MAPK_SIGNALING_PATHWAY",-0.42418,-1.27,0.176,5634,0.423,"PAK2, RASA2, HSPA8, GRB2, BRAF, RPS6KA4, MAP3K5, HSPA1A, PLA2G12A, CRK, DUSP3, PPP3CB, NFKB1, PPP3CA, MAP3K20, RPS6KA6, PPM1B, RPS6KA2, MAPKAPK2, SRF, AKT1, PRKACA, PRKCA, NFATC2, TAB1, TRAF2, HSPA6, CHUK, MAPK3, PPM1A, NF1, MAPK1, ARRB2, FAS, IKBKG, SOS1, PLA2G4A, TAB2, MAP3K7, STMN1, EGFR, CRKL, PRKCB, TP53, CACNA1A, TAOK3, RAC3, RPS6KA1, TGFB1, MOS, PPP3R1, MAP3K11, FLNA, TGFBR2, IKBKB, FLNC, STK4, HSPA2, GNG12, RPS6KA5, HSPB1, PRKCG, ARRB1, RRAS, HSPA1L, FLNB, RAC2",0.75448733218585,0.373659632624958,FALSE
+"H520","Input","KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG",-0.2979,-0.891,0.555,6339,0.667,"PKLR, MNX1, IAPP",0.255707016877324,0.175874166083451,FALSE
+"H520","Input","KEGG_MELANOGENESIS",0.22826,0.723,0.798,1560,0.91,"KITLG, FZD1, CTNNB1, TCF7L1, GNAO1, PRKACB, CREB1, TCF7L2, ADCY6, MAP2K1, GSK3B",0.0979971086492706,0.0409586076789064,FALSE
+"H520","Input","KEGG_MELANOMA",-0.35006,-1.05,0.373,6679,0.524,"MAPK3, MAPK1, MET, PIK3R3, HGF, CDK4, CDH1, CCND1, EGFR, TP53, CDKN2A, IGF1R",0.428291168191312,0.280668713016273,FALSE
+"H520","Input","KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450",0.59069,1.88,0.0158,182,0.211,"ALDH3A1, AKR1C2, AKR1C1, AKR1C3, GSTA4, GSTM2, GSTA5, EPHX1",1.80134291304558,0.675717544702307,TRUE
+"H520","Input","KEGG_MISMATCH_REPAIR",-0.51797,-1.55,0.0731,5079,0.337,"RFC5, POLD2, RFC2, RFC4, MSH6, POLD3, MSH3, RPA3, POLD1, MSH2, POLD4, MLH1, PMS2, LIG1, PCNA",1.13608262304214,0.472370099128661,FALSE
+"H520","Input","KEGG_MTOR_SIGNALING_PATHWAY",-0.44162,-1.33,0.133,5533,0.386,"AKT3, BRAF, PIK3CB, RPS6KA6, RPS6KA2, RICTOR, CAB39, AKT1, PIK3R1, MAPK3, MAPK1, TSC1, PIK3R3, RHEB, RPS6KA1",0.876148359032914,0.413412695328245,FALSE
+"H520","Input","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",-0.51619,-1.55,0.0734,5683,0.337,"GRB2, BRAF, PTPN6, PIK3CB, PPP3CB, PPP3CA, PLCG1, IFNAR1, PIK3R1, PRKCA, NFATC2, MAPK3, MAPK1, SHC1, PIK3R3, FAS, IFNGR1, BID, SOS1, ICAM2, RAET1L, ULBP2, PRKCB, ZAP70, VAV2, RAC3, PPP3R1, PLCG2, PRKCG, ICAM1, ITGB2, TNFRSF10D, RAC2",1.13430394008393,0.472370099128661,FALSE
+"H520","Input","KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION",-0.34073,-1.03,0.385,6304,0.529,"CHRNE, NR3C1, PARD3, FPR2, TSPO, PLG, HCRTR1",0.414539270491499,0.276544327964814,FALSE
+"H520","Input","KEGG_NEUROTROPHIN_SIGNALING_PATHWAY",-0.48462,-1.49,0.0836,5683,0.372,"GRB2, BRAF, RPS6KA4, MAP3K5, PIK3CB, CRK, NFKB1, PLCG1, RPS6KA6, NFKBIB, IRAK4, RPS6KA2, MAPKAPK2, ZNF274, NGFR, CAMK2D, AKT1, PIK3R1, YWHAZ, MAPK3, ABL1, RHOA, MAPK1, SHC1, YWHAE, YWHAQ, IRS2, PIK3R3, SOS1, ARHGDIA, YWHAG, YWHAH, YWHAB, CRKL, TP53, RPS6KA1, PLCG2, IRS1, PRKCD, IKBKB, ARHGDIB, RPS6KA5",1.07779372256098,0.429457060118102,FALSE
+"H520","Input","KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM",-0.4936,-1.48,0.0876,7280,0.371,"ENPP1, NT5C2, NNMT, PNP, QPRT, NAMPT, NT5E",1.05749589383192,0.430626090384954,FALSE
+"H520","Input","KEGG_NITROGEN_METABOLISM",0.41043,1.3,0.154,106,0.32,"CA8, GLUD2",0.812479279163537,0.494850021680094,FALSE
+"H520","Input","KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.57708,-1.75,0.0274,5875,0.508,"CCL13, NFKB1, SUGT1, NFKBIB, TAB1, HSP90AB1, CASP8, CHUK, MAPK3, HSP90AA1, MAPK1, BIRC2, IKBKG, TAB2, MAP3K7, TAB3, IKBKB, IL6, IL18, TRIP6",1.56224943717961,0.294136287716081,FALSE
+"H520","Input","KEGG_NON_HOMOLOGOUS_END_JOINING",-0.23537,-0.702,0.834,7371,0.889,"XRCC4",0.0788339493622613,0.0510982390297863,FALSE
+"H520","Input","KEGG_NON_SMALL_CELL_LUNG_CANCER",-0.51999,-1.57,0.0579,6266,0.399,"AKT1, PIK3R1, PRKCA, MAPK3, MAPK1, ERBB2, PIK3R3, SOS1, CDK4, CCND1, EGFR, PRKCB, TP53, PLCG2, STK4, CDKN2A, PRKCG, RXRG",1.23732143627256,0.399027104313252,FALSE
+"H520","Input","KEGG_NOTCH_SIGNALING_PATHWAY",-0.15114,-0.457,1,6322,0.998,"NUMB, DTX3L, NOTCH2, NUMBL, NCOR2, NOTCH3",0,0.000869458712628891,FALSE
+"H520","Input","KEGG_NUCLEOTIDE_EXCISION_REPAIR",-0.24838,-0.742,0.783,5785,0.838,"POLD3, ERCC5, RBX1, RAD23A, RPA3, POLD1, POLD4, POLE3, POLE2, LIG1, POLE, PCNA, RAD23B, DDB2",0.106238237942057,0.0767559813697235,FALSE
+"H520","Input","KEGG_N_GLYCAN_BIOSYNTHESIS",0.5139,1.59,0.0683,1249,0.294,"MAN2A1, MAN1A1, ALG9, MGAT1, ALG3, STT3A, MAN1C1, DOLPP1, ST6GAL1, ALG5, MOGS, ALG1, GANAB, RPN2",1.16557929631847,0.531652669587843,FALSE
+"H520","Input","KEGG_OLFACTORY_TRANSDUCTION",0.22785,0.72,0.817,1766,0.898,"CNGB1, PRKACB, CALML3",0.0877779434675845,0.0467236633326956,FALSE
+"H520","Input","KEGG_ONE_CARBON_POOL_BY_FOLATE",0.44863,1.38,0.117,1173,0.278,"MTHFS, MTHFR, MTHFD2, MTFMT, MTHFD1L",0.931814138253838,0.555955204081924,FALSE
+"H520","Input","KEGG_OOCYTE_MEIOSIS",-0.37421,-1.13,0.287,5628,0.471,"CDK2, PPP1CA, PPP2CB, CDC26, PPP3CB, PPP2R5A, PPP2R1A, PPP3CA, RBX1, RPS6KA6, AR, RPS6KA2, CAMK2D, PRKACA, YWHAZ, MAPK3, PLK1, AURKA, MAPK1, YWHAE, YWHAQ, YWHAG, YWHAH, STAG3, YWHAB, CCNB1, RPS6KA1, MOS, PPP3R1, ITPR3, ADCY9, IGF1R",0.542118103266008,0.326979092871104,FALSE
+"H520","Input","KEGG_OTHER_GLYCAN_DEGRADATION",0.20708,0.647,0.922,317,0.94,"MANBA",0.0352690789463706,0.0268721464003014,FALSE
+"H520","Input","KEGG_OXIDATIVE_PHOSPHORYLATION",0.49024,1.48,0.103,2838,0.268,"SDHD, ATP5MC2, NDUFA6, ATP5F1C, NDUFS7, UQCRH, ATP6V0A1, ATP5PO, COX11, ATP5PB, ATP5MG, ATP5F1B, ATP5F1E, ATP6V0A2, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, ATP5ME, NDUFA4, NDUFB7, SDHC, NDUFB4, NDUFS8, NDUFS6, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP6V1B2, ATP5PD, NDUFA10, NDUFB8, ATP12A, NDUFV1, ATP6V1D, ATP6V1H, SDHB, NDUFS4, NDUFS3, COX4I1, NDUFAB1, NDUFS1, COX7C, NDUFS2, ATP6V0D1, NDUFB2, ATP6AP1, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, ATP6V1A, UQCRQ, ATP6V1E1, NDUFB10, SDHA, ATP6V1G1, NDUFB9, NDUFC1, UQCRC1",0.987162775294828,0.571865205971211,FALSE
+"H520","Input","KEGG_O_GLYCAN_BIOSYNTHESIS",0.36792,1.16,0.247,986,0.437,"GCNT1, GALNT10, GALNT6",0.607303046740334,0.359518563029578,FALSE
+"H520","Input","KEGG_P53_SIGNALING_PATHWAY",-0.48802,-1.47,0.09,6533,0.37,"CASP8, RCHY1, CHEK2, RRM2, FAS, SERPINB5, BID, CDK4, CCND1, APAF1, TP53, CCNB1, DDB2, CD82, CDKN2A, SERPINE1",1.04575749056068,0.431798275933005,FALSE
+"H520","Input","KEGG_PANCREATIC_CANCER",-0.38737,-1.18,0.236,6667,0.447,"CHUK, MAPK3, MAPK1, ERBB2, PIK3R3, IKBKG, CDK4, STAT1, CCND1, EGFR, TP53, RAC3, TGFB1, TGFBR2, IKBKB, CDKN2A, RAC2",0.627087997029893,0.349692476868064,FALSE
+"H520","Input","KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS",-0.39467,-1.17,0.25,6861,0.447,"BCAT2, ENPP1, DPYD",0.602059991327962,0.349692476868064,FALSE
+"H520","Input","KEGG_PARKINSONS_DISEASE",0.42956,1.38,0.141,2560,0.278,"SLC25A4, UCHL1, SDHD, ATP5MC2, NDUFA6, ATP5F1C, NDUFS7, UQCRH, VDAC1, ATP5PO, ATP5PB, ATP5F1B, ATP5F1E, VDAC3, ATP5F1A, NDUFA9, CYC1, NDUFB3, NDUFA7, NDUFA4, NDUFB7, SLC25A31, SDHC, NDUFB4, NDUFS8, SLC25A5, NDUFS6, NDUFS5, NDUFC2, UQCRC2, UQCRFS1, ATP5PD, NDUFA10, NDUFB8, SLC25A6, NDUFV1, VDAC2, SDHB, NDUFS4, NDUFS3, COX4I1, NDUFAB1, NDUFS1, COX7C, NDUFS2, NDUFB2, NDUFV2, COX7A2L, NDUFB6, UQCRB, NDUFA3, UQCRQ, SNCA",0.85078088734462,0.555955204081924,FALSE
+"H520","Input","KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION",-0.34035,-1.04,0.367,5780,0.526,"TUBB, ARPC3, TUBA1C, ARPC2, OCLN, HCLS1, ACTB, PRKCA, WASL, YWHAZ, ROCK2, WAS, ABL1, RHOA, CTTN, ROCK1, YWHAQ, TUBB1, TUBB3, ARPC1B, ARPC5, CDH1, ITGB1, TUBB4B, EZR, TUBA4A",0.435333935747911,0.279014255846261,FALSE
+"H520","Input","KEGG_PATHWAYS_IN_CANCER",-0.37667,-1.12,0.29,5628,0.473,"CDK2, CTNNA1, STAT3, ITGA2, GRB2, BRAF, DVL2, MITF, STAT5A, CTBP2, PIK3CB, CRK, RALBP1, NFKB1, MSH3, PLCG1, MMP2, RBX1, CUL2, AR, ELOC, ELOB, JAK1, AKT1, PIK3R1, TFG, PRKCA, MSH2, TRAF2, HSP90AB1, CASP8, PML, BCR, FADD, CHUK, MAPK3, ABL1, MLH1, HSP90AA1, RHOA, MAPK1, MET, ERBB2, BIRC5, CCDC6, NCOA4, BIRC2, PIK3R3, TRAF5, FAS, IKBKG, COL4A1, DAPK1, BID, HGF, SOS1, ITGA2B, CDK4, CKS1B, CDH1, STAT1, CCND1, ITGB1, EGFR, CRKL, PRKCB, TP53, LAMA3, LAMA4, TRAF1, RAC3, TPM3, TGFB1, ITGAV, PLCG2, TGFBR2, LAMB3, LAMB1, DAPK3, IKBKB, STK4, IL6, CDKN2A, PRKCG, RXRG, ITGA3, PTGS2, IGF1R, ETS1, RAC2",0.537602002101044,0.325138859262188,FALSE
+"H520","Input","KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS",-0.40957,-1.22,0.203,5708,0.406,"GUSB, AKR1B1, UGP2, RPE, UGDH, XYLB",0.692503962086787,0.391473966422806,FALSE
+"H520","Input","KEGG_PENTOSE_PHOSPHATE_PATHWAY",-0.4555,-1.37,0.141,5189,0.382,"TALDO1, TKT, H6PD, PGM2, ALDOC, RPE, FBP2, RBKS, RPIA, PFKL, G6PD, DERA, ALDOA, PGM1, PFKP",0.85078088734462,0.417936637088291,FALSE
+"H520","Input","KEGG_PEROXISOME",0.30174,0.952,0.452,797,0.633,"PIPOX, PRDX1, SOD1, PECR, SLC27A2, MLYCD, PAOX, ACSL5, PEX12",0.344861565188618,0.198596289982645,FALSE
+"H520","Input","KEGG_PHENYLALANINE_METABOLISM",0.73163,2.28,0.00256,282,0.238,"MAOB, ALDH3A1, MAOA, GOT2",2.59176003468815,0.623423042943488,TRUE
+"H520","Input","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",-0.40811,-1.23,0.206,5775,0.422,"PIK3CB, OCRL, ITPKB, PLCG1, CDS2, DGKZ, PIK3R1, PRKCA, PIP4K2C, SYNJ2, CDS1, DGKH, PLCB3, PIK3R3, INPP1, PLCD3, PRKCB, PLCG2, ITPK1, IMPA2, ITPR3, ITPKA, PRKCG, INPP4B, DGKA",0.686132779630847,0.374687549038326,FALSE
+"H520","Input","KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM",0.28697,0.89,0.544,502,0.688,"UROD, FECH, EARS2",0.26440110030182,0.162411561764489,FALSE
+"H520","Input","KEGG_PPAR_SIGNALING_PATHWAY",-0.2927,-0.883,0.59,6896,0.674,"SCP2, APOA1, ILK, DBI, LPL, ACSL4, SCD5, HMGCS2, FABP3, RXRG, PLTP",0.229147988357856,0.17134010346468,FALSE
+"H520","Input","KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS",0.63243,1.96,0.0105,654,0.216,"AKR1D1, CYP27A1",1.97881070093006,0.665546248849069,TRUE
+"H520","Input","KEGG_PRIMARY_IMMUNODEFICIENCY",-0.39409,-1.19,0.241,6020,0.44,"TAP1, TAP2, ADA, CD40, IKBKG, ZAP70",0.617982957425132,0.356547323513813,FALSE
+"H520","Input","KEGG_PRION_DISEASES",0.44472,1.41,0.125,217,0.282,"C9, NCAM1, SOD1",0.903089986991944,0.549750891680639,FALSE
+"H520","Input","KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION",-0.38646,-1.17,0.244,5533,0.447,"AKT3, CDK2, BRAF, PIK3CB, CDC26, RPS6KA6, RPS6KA2, AKT1, PIK3R1, PRKACA, HSP90AB1, MAPK3, HSP90AA1, PLK1, MAPK1, CCNA2, PIK3R3, FZR1, CCNB1, RPS6KA1, MOS, ADCY9, IGF1R",0.612610173661271,0.349692476868064,FALSE
+"H520","Input","KEGG_PROPANOATE_METABOLISM",0.46117,1.48,0.0801,1311,0.268,"ACSS3, ALDH2, HIBCH, ALDH3A2, MLYCD, SUCLA2, PCCA, PCCB, ALDH7A1, ALDH9A1",1.09636748391576,0.571865205971211,FALSE
+"H520","Input","KEGG_PROSTATE_CANCER",-0.30533,-0.933,0.505,5450,0.628,"RELA, CREB5, AKT3, CDK2, GRB2, BRAF, PIK3CB, NFKB1, AR, AKT1, PIK3R1, HSP90AB1, CHUK, MAPK3, HSP90AA1, MAPK1, ERBB2, PIK3R3, IKBKG, SOS1, CCND1, EGFR, TP53, IKBKB, IGF1R",0.296708621881339,0.202040356262804,FALSE
+"H520","Input","KEGG_PROTEASOME",-0.42296,-1.25,0.209,4848,0.435,"PSMC2, PSMC5, PSMC4, PSMC6, PSMC3, PSMA8, PSMD4, PSMF1, PSMB2, PSMA4, PSMB1, PSMA6, PSMA5, PSMB7, PSMA1, PSMB6, PSMB8, PSMA2, PSMA7, PSMA3, PSMB3, PSME3, PSMB9",0.679853713888946,0.361510743045363,FALSE
+"H520","Input","KEGG_PROTEIN_EXPORT",0.56486,1.8,0.027,2936,0.181,"SRP14, SEC63, SRPRB, SRP9, SEC62, SRPRA, SEC11C, SPCS2, SEC61A1, SPCS3, SRP19, SEC61B, SEC11A, SRP72, OXA1L",1.56863623584101,0.742321425130815,TRUE
+"H520","Input","KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION",0.37785,1.18,0.237,1973,0.434,"GLUD2, SLC25A10, PCK2, ATP1B1, ATP1B3, ATP1A3, ATP1A1, ATP1A4",0.625251653989896,0.362510270487489,FALSE
+"H520","Input","KEGG_PURINE_METABOLISM",-0.21898,-0.638,0.918,6302,0.943,"PRIM1, POLD1, PKLR, AMPD2, NME6, PRIM2, POLD4, DCK, POLE3, NME7, ADA, POLE2, PFAS, CANT1, RRM2, IMPDH2, POLE, ADSL, ENPP1, NT5C2, IMPDH1, PNP, PAPSS2, AK1, AMPD3, ADCY9, POLR2F, NT5E",0.0371573187987575,0.0254883072626717,FALSE
+"H520","Input","KEGG_PYRIMIDINE_METABOLISM",-0.31055,-0.95,0.469,6302,0.606,"PRIM1, POLD1, NME6, PRIM2, POLD4, UCKL1, DCTD, DCK, POLE3, NME7, TYMP, POLE2, CANT1, RRM2, POLE, NT5C2, CMPK1, PNP, DPYD, POLR2F, NT5E, UPP1, UPRT, CDA",0.328827157284917,0.217527375833714,FALSE
+"H520","Input","KEGG_PYRUVATE_METABOLISM",0.25474,0.796,0.699,1862,0.807,"ALDH2, ALDH3A2, HAGH, ME1, PCK2, GRHPR, PKM, ALDH7A1, ALDH9A1, ME3, ALDH1B1, ACYP2, PDHA1",0.155522824254319,0.0931264652779296,FALSE
+"H520","Input","KEGG_REGULATION_OF_ACTIN_CYTOSKELETON",-0.46502,-1.41,0.109,6625,0.385,"WAS, PIP4K2C, MAPK3, ITGB3, DOCK1, RHOA, MAPK1, ACTN2, LIMK1, ACTN1, ROCK1, PIK3R3, ARHGAP35, ITGB5, ARPC1B, ENAH, SOS1, ARPC5, ITGA2B, SSH1, IQGAP2, PXN, CFL2, ITGB1, PPP1R12A, MYL12A, EGFR, CRKL, GSN, VAV2, SCIN, RAC3, VCL, ITGAV, BAIAP2, ITGA1, MOS, IQGAP3, EZR, MYH9, SSH3, MYH14, IQGAP1, PFN1, MYL9, GNG12, ITGA3, ITGB2, RRAS, ITGA5, RAC2, ITGB6",0.962573502059376,0.414539270491499,FALSE
+"H520","Input","KEGG_REGULATION_OF_AUTOPHAGY",-0.27683,-0.843,0.618,5778,0.715,"ATG7, ATG12, ATG3, ATG5",0.209011524911184,0.145693958198919,FALSE
+"H520","Input","KEGG_RENAL_CELL_CARCINOMA",-0.33678,-1.01,0.409,5533,0.534,"AKT3, PAK2, GRB2, BRAF, PIK3CB, CRK, RBX1, CUL2, ELOC, ELOB, AKT1, PIK3R1, MAPK3, MAPK1, MET, PIK3R3, HGF, SOS1, CRKL, TGFB1, ETS1",0.388276691992658,0.272458742971444,FALSE
+"H520","Input","KEGG_RENIN_ANGIOTENSIN_SYSTEM",0.36845,1.14,0.262,29,0.44,"MME",0.581698708680255,0.356547323513813,FALSE
+"H520","Input","KEGG_RETINOL_METABOLISM",0.51088,1.58,0.0622,1421,0.283,"RDH11, ALDH1A1, PNPLA4, RETSAT, ALDH1A2",1.20620961530918,0.54821356447571,FALSE
+"H520","Input","KEGG_RIBOFLAVIN_METABOLISM",0.36275,1.14,0.274,609,0.44,"RFK, MTMR2, ACP2",0.562249437179612,0.356547323513813,FALSE
+"H520","Input","KEGG_RIBOSOME",0.153,0.472,0.995,3690,0.997,"RPL26L1, RPL37, RPS27A, RPL24, RSL24D1, RPS8, RPL22, RPL29, RPS6, MRPL13, RPL13, RPS15A, RPS3A, RPS7, RPS25, RPS24, RPL35A, RPL4, RPS10, RPS16, RPS13, RPL19, RPS4X, RPL6, RPL13A, RPL23, RPS23, RPL23A, RPL8, RPS9, RPL7, RPS18, RPS11, RPL34, RPL14, RPL30, RPL3, RPS2, FAU, RPL21, RPS20, RPL5",0.00217691925427455,0.00130484168834428,FALSE
+"H520","Input","KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.48029,-1.45,0.092,5897,0.369,"TBK1, NFKB1, AZI2, ATG12, NFKBIB, RIPK1, ATG5, TANK, TRAF2, CASP8, FADD, CHUK, TRADD, IKBKG, DDX58, IRF3, MAP3K7, IKBKB, ISG15",1.03621217265444,0.43297363384094,FALSE
+"H520","Input","KEGG_RNA_DEGRADATION",0.22064,0.708,0.852,3163,0.887,"DCPS, HSPA9, ZCCHC7, MPHOSPH6, PARN, EXOSC10, MTREX, PAPOLG, EXOSC3, HSPD1, EXOSC1, LSM3, LSM2, CNOT10, EXOSC7, EDC3, EDC4, LSM1, CNOT2, DDX6, CNOT1, LSM4, EXOSC9, CNOT7, EXOSC5, DCP2, DCP1A",0.0695604052332999,0.0520763801682736,FALSE
+"H520","Input","KEGG_RNA_POLYMERASE",0.30796,0.996,0.374,3081,0.583,"POLR2A, POLR3A, POLR2B, POLR2H, POLR1C, POLR1D, POLR2K, POLR1A, POLR1E, POLR2G, POLR2E, POLR1B, POLR2D, POLR3C, POLR2C, POLR2L",0.42712839779952,0.234331445240986,FALSE
+"H520","Input","KEGG_SELENOAMINO_ACID_METABOLISM",-0.26488,-0.794,0.694,5914,0.768,"SEPHS1, METTL2B, AHCY, AHCYL2, CTH, PAPSS2, GGT1",0.158640529545145,0.114638779968488,FALSE
+"H520","Input","KEGG_SMALL_CELL_LUNG_CANCER",-0.5242,-1.58,0.0715,7025,0.406,"BIRC2, PIK3R3, TRAF5, IKBKG, COL4A1, ITGA2B, CDK4, CKS1B, CCND1, APAF1, ITGB1, TP53, LAMA3, LAMA4, TRAF1, ITGAV, LAMB3, LAMB1, IKBKB, RXRG, ITGA3, PTGS2",1.14569395819892,0.391473966422806,FALSE
+"H520","Input","KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT",0.33357,1.05,0.359,1370,0.533,"GOSR1, SEC22B, STX5, BET1L, BNIP1, STX2, VTI1B",0.444905551421681,0.273272790973428,FALSE
+"H520","Input","KEGG_SPHINGOLIPID_METABOLISM",0.33427,1.07,0.313,1892,0.517,"SGPL1, GALC, PLPP2, PLPP1, ARSA, SMPD4, DEGS1, SMPD1",0.504455662453552,0.286509456906058,FALSE
+"H520","Input","KEGG_SPLICEOSOME",0.46963,1.45,0.0968,3233,0.269,"HNRNPU, RBMX, PRPF38B, PRPF38A, ALYREF, U2SURP, THOC2, DDX5, SNRPA, ACIN1, TRA2B, XAB2, HNRNPA1, SF3A2, PPIE, HNRNPM, PRPF40B, THOC1, SNRPA1, PRPF8, SNRNP200, AQR, SRSF6, RBM17, SF3B1, ZMAT2, SRSF9, CDC5L, HNRNPA3, TXNL4A, SNW1, SNRNP27, PRPF40A, CHERP, SART1, RBM22, BUD31, SRSF2, SNRPB2, SRSF4, PRPF31, SRSF1, EFTUD2, SF3B3, SRSF3, SF3B6, DDX39B, CTNNBL1, SLU7, SRSF5, SNU13, SRSF10, PRPF19, PLRG1, USP39, CDC40, MAGOHB, SNRPD1, SNRPD2, SNRNP40, SNRPD3, THOC3, EIF4A3, LSM3, LSM2, PRPF18, PUF60, SF3A3, DDX23, SMNDC1, HNRNPK, ISY1, PRPF6, DHX8, NCBP1, RBM8A, CRNKL1, DDX46, DHX15, SRSF8, SRSF7, CWC15, U2AF1, DHX16, LSM4, DHX38, PHF5A, RBM25, HNRNPC, SNRPC, PRPF3, SF3A1, TCERG1, TRA2A, SNRPE, BCAS2, U2AF2, PRPF4",1.01412464269161,0.570247719997592,FALSE
+"H520","Input","KEGG_STARCH_AND_SUCROSE_METABOLISM",-0.43117,-1.3,0.157,7280,0.409,"ENPP1, UGDH, PYGB, PGM1, SI",0.804100347590766,0.388276691992658,FALSE
+"H520","Input","KEGG_STEROID_BIOSYNTHESIS",-0.36819,-1.08,0.331,4944,0.505,"CEL, LIPA, SOAT1, CYP51A1, FDFT1, NSDHL, SOAT2, LSS, DHCR24, MSMO1",0.480172006224281,0.296708621881339,FALSE
+"H520","Input","KEGG_STEROID_HORMONE_BIOSYNTHESIS",0.6384,2,0.0169,391,0.299,"AKR1C2, AKR1C1, AKR1D1, AKR1C3, HSD17B8, HSD17B12",1.77211329538633,0.52432881167557,FALSE
+"H520","Input","KEGG_SULFUR_METABOLISM",-0.55996,-1.63,0.0585,7088,0.481,"SULT1A3, PAPSS2, SULT2B1, CHST12",1.23284413391782,0.317854923626168,FALSE
+"H520","Input","KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS",0.35929,1.12,0.295,357,0.456,"C9, C4A",0.530177984021837,0.341035157335565,FALSE
+"H520","Input","KEGG_TASTE_TRANSDUCTION",-0.28496,-0.841,0.642,7599,0.711,"CACNA1A, ITPR3",0.192464971931147,0.148130399270234,FALSE
+"H520","Input","KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS",-0.45822,-1.37,0.117,4926,0.382,"IDI1, HMGCS1, ACAT1, HMGCR, PMVK, MVK, ACAT2, PDSS2, MVD, FDPS, DHDDS, HMGCS2",0.931814138253838,0.417936637088291,FALSE
+"H520","Input","KEGG_TGF_BETA_SIGNALING_PATHWAY",0.27686,0.855,0.607,44,0.711,"INHBE, TGFB2",0.216811308924742,0.148130399270234,FALSE
+"H520","Input","KEGG_THYROID_CANCER",-0.48955,-1.43,0.1,6679,0.383,"MAPK3, MAPK1, CCDC6, NCOA4, CDH1, CCND1, TP53, TPM3, RXRG",1,0.416801226031377,FALSE
+"H520","Input","KEGG_TIGHT_JUNCTION",-0.42686,-1.31,0.151,5970,0.405,"PPP2R1A, PATJ, ACTN4, MAP3K20, OCLN, HCLS1, ACTB, TJAP1, AKT1, PPP2R2A, PRKCA, MYH10, LLGL1, PRKCI, EXOC4, RHOA, ACTN2, PARD3, CTTN, ACTN1, CLDN11, EXOC3, CDK4, TJP2, MYL12A, TJP3, PRKCB, CGN, MYH11, MYH9, MYH14, MYH7B, PRKCD, MYL9, PARD6B, AMOTL1, PRKCQ, PARD6G, CLDN4, PRKCG, RRAS, CLDN6",0.821023052706831,0.392544976785331,FALSE
+"H520","Input","KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY",-0.34888,-1.06,0.35,5420,0.522,"TOLLIP, RELA, AKT3, TLR9, PIK3CB, TBK1, NFKB1, IRAK4, IFNAR1, RIPK1, AKT1, PIK3R1, TAB1, CASP8, FADD, MYD88, CHUK, MAPK3, MAPK1, CD40, PIK3R3, IKBKG, STAT1, IRF3, TAB2, MAP3K7, IKBKB, IL6",0.455931955649724,0.282329496997738,FALSE
+"H520","Input","KEGG_TRYPTOPHAN_METABOLISM",0.5571,1.78,0.0448,535,0.18,"MAOB, ALDH2, WARS2, MAOA, ALDH3A2, AADAT",1.34872198600186,0.744727494896694,TRUE
+"H520","Input","KEGG_TYPE_II_DIABETES_MELLITUS",-0.41814,-1.26,0.186,6303,0.429,"PIK3R1, PKLR, MAPK3, MAPK1, IRS2, PIK3R3, CACNA1A, IRS1, PRKCD, IKBKB",0.730487055782084,0.367542707815276,FALSE
+"H520","Input","KEGG_TYROSINE_METABOLISM",0.49964,1.54,0.0982,725,0.304,"MAOB, ALDH3A1, MAOA, GOT2, TRMT11, GSTZ1",1.00788851221305,0.517126416391246,FALSE
+"H520","Input","KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY",-0.41643,-1.23,0.202,5634,0.422,"PAK2, GRB2, PTPN6, PIK3CB, PPP3CB, NFKB1, PPP3CA, PLCG1, NFKBIB, AKT1, PIK3R1, NFATC2, BCL10, CHUK, MAPK3, RHOA, MAPK1, PIK3R3, IKBKG, SOS1, CDK4, MAP3K7, ZAP70, VAV2, PPP3R1, IKBKB, PRKCQ, CARD11",0.694648630553376,0.374687549038326,FALSE
+"H520","Input","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",-0.33138,-0.983,0.452,5714,0.571,"UBE2G2, WWP1, CDC26, UBE2E2, BIRC6, FANCL, UBE2J2, UBA6, RBX1, CUL2, ELOC, UBE2Q1, FBXO2, ELOB, SMURF2, STUB1, UBE2S, UBE3C, RCHY1, PML, ITCH, UBE2M, UBE2G1, UBE2F, BRCA1, UBA1, BIRC2, UBE4B, UBE2H, FZR1, UBE2L3, NEDD4L, TRIM32, DDB2, UBOX5, UBE2E3, UBA7, UBE2C",0.344861565188618,0.243363891754152,FALSE
+"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS",0.28191,0.876,0.596,2738,0.699,"LARS2, PDHA1, PDHB, BCAT1",0.224753740259764,0.155522824254319,FALSE
+"H520","Input","KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",0.40491,1.32,0.16,2272,0.322,"ACAA2, ALDH2, HIBCH, ACAD8, ALDH3A2, MCCC1, BCKDHB, IVD, PCCA, PCCB, ALDH7A1, ALDH9A1, HSD17B10, BCKDHA, ALDH1B1, MCEE, OXCT1, HADH, HADHA, ECHS1, ALDH6A1, MCCC2, ACADSB",0.795880017344075,0.492144128304169,FALSE
+"H520","Input","KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION",-0.40861,-1.22,0.211,6559,0.406,"ROCK2, MAPK3, RHOA, MAPK1, ACTA2, ROCK1, PLCB3, PPP1R12B, PLA2G4A, PPP1R12A, MYL6B, PRKCB, CALD1, MYH11, PRKCD, MYL9, ITPR3, ADCY9, PRKCQ, PRKCG, MYL6",0.675717544702307,0.391473966422806,FALSE
+"H520","Input","KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION",-0.38101,-1.14,0.271,5425,0.469,"VAMP2, CREB5, RAB11A, RAB5B, DCTN4, DCTN1, DYNC1I2, AVP, PRKACA, DCTN5, DCTN2, DYNC1LI1, DCTN6, ARHGDIA, ARHGDIB, ADCY9",0.567030709125594,0.328827157284917,FALSE
+"H520","Input","KEGG_VEGF_SIGNALING_PATHWAY",-0.52027,-1.55,0.0728,5775,0.337,"PIK3CB, PLA2G12A, PPP3CB, PPP3CA, PLCG1, MAPKAPK2, AKT1, PIK3R1, PRKCA, NFATC2, MAPK3, MAPK1, PIK3R3, PXN, PLA2G4A, PRKCB, RAC3, PPP3R1, PLCG2, HSPB1, PRKCG, PTGS2, RAC2",1.13786862068696,0.472370099128661,FALSE
+"H520","Input","KEGG_VIBRIO_CHOLERAE_INFECTION",-0.38574,-1.16,0.248,7397,0.455,"TJP2, PRKCB, PLCG2, TCIRG1, ATP6V0A4, ADCY9, KDELR3, PRKCG",0.605548319173784,0.341988603342888,FALSE
+"H520","Input","KEGG_VIRAL_MYOCARDITIS",-0.57258,-1.73,0.041,6409,0.43,"MYH10, DAG1, CASP8, ABL1, CD40, BID, CAV1, CCND1, CD55, RAC3, MYH11, MYH9, MYH14, MYH7B, ICAM1, ITGB2, RAC2",1.38721614328026,0.366531544420413,FALSE
+"H520","Input","KEGG_WNT_SIGNALING_PATHWAY",-0.2965,-0.9,0.542,5660,0.68,"PLCB4, DVL2, CTBP2, PPP2CB, PPP3CB, PPP2R5A, PPP2R1A, PPP3CA, RBX1, TBL1XR1, CAMK2D, PRKACA, PRKCA, NFATC2, ROCK2, RHOA, PORCN, ROCK1, PLCB3, CACYBP, CCND1, MAP3K7, PRKCB, TP53, RAC3, FOSL1, PPP3R1, PRKCG, CSNK1A1, RAC2",0.266000713461613,0.167491087293764,FALSE
diff --git a/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_venn_diagram.pdf b/Examples/cell_corr/Fig8_Coldren_prot_NSCLC/GSEA/GSEA_venn_diagram.pdf
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diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_correlation_matrix.pdf b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_correlation_matrix.pdf
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diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_dot_plot.pdf b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_dot_plot.pdf
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diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_interactive_network.graph.html b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
index 0000000..dcf1c00
--- /dev/null
+++ b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNFQxNDo0MTowNCswMTowMDwveG1wOk1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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-f03c13f2e091465ae1f9" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv
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@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"retinoid receptor agonist",0.92605,1.09193924426128,1.66400152023328e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1650, HCC44",0.000153457917977069
+"AP inhibitor",0.5873,1.08658620894694,0.0438754357167872,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.1102480208072
+"benzodiazepine receptor agonist",0.4223,0.895357740911713,0.865382426366316,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"PPAR receptor agonist",0.38665,1.15610977784164,0.0530154216941511,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.12223000001707
+"bacterial DNA gyrase inhibitor",0.35545,1.2284457220835,0.012649125448034,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.0415394694008123
+"calcium channel blocker",0.29445,1.0616762057188,0.402547831280457,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.604470685832317
+"mTOR inhibitor",0.26405,1.02621355502952,0.592236071461401,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.80695747500506
+"thymidylate synthase inhibitor",0.2137,1.43089953672874,7.39328678363733e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H1650, H1975",0.000122703989735374
+"adrenergic receptor antagonist",0.19995,0.892149118701577,0.977749368256249,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"adenosine receptor antagonist",0.18895,1.29351233286087,0.00190836375351865,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H1650",0.00791970957710239
+"RAF inhibitor",0.1679,1.23716347471056,0.0130123639086882,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.0415394694008123
+"CC chemokine receptor antagonist",0.1142,1.05000965409096,0.566913414297166,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.797522260790928
+"glutamate receptor antagonist",0.10475,0.770982891133813,0.999978974219987,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"DNA methyltransferase inhibitor",0.086,1.29129469912952,0.00358354270471327,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC15",0.0123930851871334
+"FGFR inhibitor",0.02035,1.33518231654746,0.000302255460173701,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC2279",0.00179194308531551
+"glycogen synthase kinase inhibitor",0.00310000000000001,0.987101386570002,0.810811589422749,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"DNA inhibitor",-0.00239999999999997,0.800987114687082,0.99984380739688,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"VEGFR inhibitor",-0.01115,1.00782753719912,0.808224861401723,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"cytochrome P450 inhibitor",-0.01675,1.06010162745197,0.640402283544856,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.857312734422952
+"phosphatase inhibitor",-0.0243,0.896128990949993,0.993894468034018,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"ATPase inhibitor",-0.0527,1.12959480858357,0.268011224251416,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.427787146401299
+"ALK tyrosine kinase receptor inhibitor",-0.0541,1.0203735074652,0.766561794889117,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.978840445781488
+"PI3K inhibitor",-0.1006,0.790835427686577,0.999900114130944,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"protein synthesis inhibitor",-0.10245,0.860060247277694,0.997930617016542,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"sodium channel blocker",-0.1224,0.953706972541191,0.937628741184561,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"TGF beta receptor inhibitor",-0.12615,1.38715696660472,1.01999320054934e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H358, H3255",0.000122703989735374
+"EGFR inhibitor",-0.13285,0.801937408963279,0.999775733491809,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"potassium channel blocker",-0.1357,1.07544923783408,0.487287581057094,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.697325331512739
+"progesterone receptor agonist",-0.1384,1.28912334145096,0.0292190473696394,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.0757869041150023
+"HCV inhibitor",-0.1441,1.15067270484887,0.129682874394435,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.244629058516775
+"HMGCR inhibitor",-0.14745,1.46506617328545,4.79148424610221e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H1650, HCC4006, HCC2279, H520",0.000397693192426484
+"adrenergic receptor agonist",-0.1578,1.03727261807614,0.670118751083818,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.882854862538999
+"topoisomerase inhibitor",-0.1712,1.16045384043894,0.118133051059189,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"HCC95, H520",0.228024261346806
+"MET inhibitor",-0.1739,1.48528363054263,1.33838081003218e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H2126, CALU3, H520, A549",0.000138857009040839
+"acetylcholine receptor antagonist",-0.17865,1.1797608265639,0.0666301937506903,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H358, H1703",0.149467731927224
+"phosphodiesterase inhibitor",-0.1988,0.883495545516427,0.988362896984305,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"RET tyrosine kinase inhibitor",-0.21205,1.32006014516086,0.00189976072233017,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.00791970957710239
+"sterol demethylase inhibitor",-0.22645,1.33126997044571,0.000467871198965814,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC4006",0.00258888730094417
+"bacterial 50S ribosomal subunit inhibitor",-0.2339,1.26490515142649,0.00258517790325817,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00975317118047402
+"src inhibitor",-0.2649,1.29879745594875,0.000806675370735804,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.00393847386888658
+"estrogen receptor antagonist",-0.2942,1.19480148538311,0.0881483331885304,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.187597734734565
+"ribonucleotide reductase inhibitor",-0.2995,1.14715540634902,0.0763237338277799,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.166707102834361
+"KIT inhibitor",-0.3422,1.08505205308074,0.173851148824212,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.307013730902332
+"DNA polymerase inhibitor",-0.34505,1.08193853677943,0.208523400702626,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.353213107312612
+"vitamin D receptor agonist",-0.35875,1.23239868271509,0.0160218853261817,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H1650, H460, H1703",0.0462166081139457
+"histamine receptor antagonist",-0.3755,0.781867837802191,0.996651950634769,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"tyrosine kinase inhibitor",-0.37635,0.900661352036731,0.906593074797396,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"PDGFR tyrosine kinase receptor inhibitor",-0.3846,1.02518180159218,0.40783564345313,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.604470685832317
+"androgen receptor antagonist",-0.3849,1.18804256967855,0.0194859168743378,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.0539110366856679
+"PLK inhibitor",-0.4099,1.39722996261211,5.35147324679525e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H1650, HCC95, H460",1.11043069871001e-05
+"proteasome inhibitor",-0.41495,1.34652400353847,9.32231298331748e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.000703410888741228
+"dopamine receptor antagonist",-0.4209,0.82659764921285,0.977937351304792,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"tubulin polymerization inhibitor",-0.45795,0.998904582925453,0.255897843969672,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.416461197048682
+"cyclooxygenase inhibitor",-0.46155,0.660057371908326,0.999957068199221,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"MEK inhibitor",-0.46725,0.96932406590203,0.453345566109778,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.660134771703712
+"estrogen receptor agonist",-0.4684,1.03259980529474,0.201524433681871,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.348469333241568
+"Bcr.Abl kinase inhibitor",-0.4745,1.24931772959231,0.00072339100870527,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"HCC95, H520",0.00375259085765859
+"protein tyrosine kinase inhibitor",-0.47895,1.11704461933217,0.165875716007256,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H3255",0.29929748757831
+"Abl kinase inhibitor",-0.48905,1.23017702940845,0.0011063036417712,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC95",0.00510128901483389
+"acetylcholine receptor agonist",-0.49585,1.11711099552184,0.0283991624643543,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0757869041150023
+"p38 MAPK inhibitor",-0.4965,1.17283504919983,0.0022750778486948,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.00899197435436515
+"opioid receptor agonist",-0.4968,1.0426688226298,0.10860869227471,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.225363036470024
+"serotonin receptor antagonist",-0.5256,1.08338987490775,0.0451618398487325,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.1102480208072
+"NFkB pathway inhibitor",-0.53025,0.90854677920292,0.593065132232634,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.80695747500506
+"AKT inhibitor",-0.53965,0.829082071678641,0.735555867265182,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.953924015359532
+"PARP inhibitor",-0.54135,1.014687988082,0.238398411035668,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.395741362319209
+"serotonin receptor agonist",-0.5635,1.49163024556144,2.29946023290837e-10,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,7,"H358, HCC95, H3255, CALU3, H520, H460, A549",1.90855199331395e-08
+"DNA alkylating agent",-0.5669,0.802604962802866,0.88683858507367,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"microtubule inhibitor",-0.57405,0.93031033164095,0.345100923634254,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.53896982885512
+"growth factor receptor inhibitor",-0.575,1.28822807722366,1.03485292547906e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000122703989735374
+"FLT3 inhibitor",-0.58495,0.937653143982919,0.35065506937562,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.53896982885512
+"BCL inhibitor",-0.6024,1.00186932649344,0.147089944369024,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.271299230725089
+"glucocorticoid receptor agonist",-0.6055,1.00542494289205,0.11547532464001,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC15",0.228024261346806
+"DNA synthesis inhibitor",-0.64945,0.645959300901421,0.964979638325481,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999978974219987
+"MDM inhibitor",-0.65675,1.45625228710008,3.64817985908291e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,5,"H1650, H2009, H520, HCC15, HCC44",1.00932976101294e-06
+"CDK inhibitor",-0.66765,1.09091107626414,0.00276128426312658,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.00996463451476114
+"antioxidant",-0.69835,1.00875036163823,0.0135194104586792,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H358",0.0415596691877917
+"bromodomain inhibitor",-0.7544,1.39203684161773,4.89720072932298e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,6,"H358, H1650, HCC78, H520, H460, H1299",2.03233830266904e-07
+"CHK inhibitor",-0.77925,1.16100500361586,0.000123902359897899,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC95, H2126, H520",0.000856991322627132
+"JAK inhibitor",-0.8013,0.915665883674998,0.0161479715096919,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0462166081139457
+"HSP inhibitor",-0.823,0.785202622190436,0.116334408777091,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.228024261346806
+"Aurora kinase inhibitor",-1.0024,0.772281881998508,0.000191877185647698,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"HCC95, HCC44",0.00122506203144299
+"HDAC inhibitor",-1.02295,0.562461832623241,0.0467652297387959,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.110900401952002
diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_results.csv b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..f466683
--- /dev/null
+++ b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_results.csv
@@ -0,0 +1,1661 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H358","Pearson.est","EGFR inhibitor",-0.42175,-1,0.458,853,0.836,"canertinib, dovitinib, BMS.690514, XL.647, erlotinib, pelitinib, FERb.033, dacomitinib, CP.724714, icotinib, gefitinib, OSI.420, AEE788, lapatinib, ARRY.334543, AST.1306, afatinib, PD.153035, WZ8040, salvianolic.acid.B, BMS.599626, rociletinib, tucatinib, CUDC.101, osimertinib, neratinib",0.339134521996131,0.0777937225609836,FALSE
+"H358","Pearson.est","Abl kinase inhibitor",-0.44458,-1.07,0.385,996,0.78,"nilotinib, tozasertib, flumatinib, KW.2449, imatinib, bosutinib",0.414539270491499,0.10790539730952,FALSE
+"H358","Pearson.est","acetylcholine receptor agonist",-0.62096,-1.47,0.058,941,0.3,"nefiracetam, xanomeline, oxiracetam, pilocarpine",1.23657200643706,0.522878745280338,FALSE
+"H358","Pearson.est","acetylcholine receptor antagonist",-0.72832,-1.74,0.00879,1341,0.133,"methscopolamine, dicycloverine",2.05601112492623,0.876148359032914,TRUE
+"H358","Pearson.est","adenosine receptor antagonist",-0.58015,-1.37,0.119,836,0.371,"MRS.1220, SCH.58261, CGS.15943, sulmazole, theophylline, istradefylline, PSB.1115",0.924453038607469,0.430626090384954,FALSE
+"H358","Pearson.est","adrenergic receptor agonist",-0.54518,-1.31,0.153,1267,0.416,"oxymetazoline, isoetharine, midodrine, isoxsuprine, clenbuterol",0.815308569182401,0.380906669373257,FALSE
+"H358","Pearson.est","adrenergic receptor antagonist",-0.31353,-0.733,0.82,1063,0.96,"imiloxan, atenolol......, idazoxan, dronedarone, atenolol...., levobunolol",0.0861861476162833,0.0177287669604316,FALSE
+"H358","Pearson.est","AKT inhibitor",-0.53644,-1.28,0.166,1182,0.442,"palomid.529, uprosertib, AT7867, CCT128930",0.779891911959945,0.354577730650908,FALSE
+"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34633,-0.811,0.702,833,0.932,"NVP.TAE684, SB.505124, CEP.37440, alectinib, GW.788388, AZD3463, DMH1",0.153662887870195,0.0305840876460186,FALSE
+"H358","Pearson.est","androgen receptor antagonist",-0.68979,-1.64,0.0222,1258,0.161,"bicalutamide, flutamide",1.65364702554936,0.79317412396815,TRUE
+"H358","Pearson.est","antioxidant",-0.76543,-1.84,0.00375,1386,0.0842,"benfotiamine, taurine",2.42596873227228,1.07468790850035,TRUE
+"H358","Pearson.est","AP inhibitor",0.37134,1.06,0.378,49,0.709,"birinapant",0.422508200162775,0.149353764816933,FALSE
+"H358","Pearson.est","ATPase inhibitor",-0.24889,-0.596,0.931,1262,0.974,"ouabain, digoxin",0.0310503190186574,0.0114410431213845,FALSE
+"H358","Pearson.est","Aurora kinase inhibitor",-0.41916,-1.01,0.45,900,0.834,"PHA.680632, CCT137690, PF.03814735, SNS.314, ZM.447439, tozasertib, ENMD.2076, MK.8745, danusertib, AT.9283, hesperadin, KW.2449, barasertib, alisertib",0.346787486224656,0.0788339493622613,FALSE
+"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.57727,-1.37,0.109,1036,0.371,"tilmicosin, tedizolid, josamycin, dirithromycin, azalomycin.b",0.962573502059376,0.430626090384954,FALSE
+"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.53988,1.57,0.0765,278,0.296,"lomefloxacin, novobiocin, sparfloxacin, norfloxacin, finafloxacin, nadifloxacin",1.11633856484638,0.528708288941061,FALSE
+"H358","Pearson.est","BCL inhibitor",-0.37531,-0.9,0.599,864,0.886,"navitoclax, TW.37, venetoclax",0.222573177610689,0.0525662781129492,FALSE
+"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.4618,-1.09,0.361,687,0.753,"bafetinib, metatinib, GZD824, ponatinib, nilotinib, tozasertib, flumatinib, imatinib, bosutinib",0.442492798094342,0.123205023799299,FALSE
+"H358","Pearson.est","benzodiazepine receptor agonist",-0.29994,-0.715,0.819,777,0.966,"eprinomectin, CGS.20625, ZK.93423, temazepam, nefiracetam, lorazepam, piperazine",0.0867160982395816,0.0150228735845067,FALSE
+"H358","Pearson.est","bromodomain inhibitor",-0.80459,-1.91,0,1283,0.115,"bromosporine, OTX015, I.BET.762, I.BET151, JQ1....",Inf,0.939302159646388,TRUE
+"H358","Pearson.est","calcium channel blocker",-0.3515,-0.848,0.672,1103,0.889,"mibefradil, tetrandrine, SKF.96365",0.172630726946175,0.0510982390297863,FALSE
+"H358","Pearson.est","CC chemokine receptor antagonist",0.2949,0.865,0.668,19,1,"ZK811752",0.175223537524454,0,FALSE
+"H358","Pearson.est","CDK inhibitor",-0.70134,-1.68,0.0164,1213,0.153,"aminopurvalanol.a, arcyriaflavin.a, JNJ.7706621, dinaciclib, abemaciclib, P276.00, R547, PHA.848125, kenpaullone, palbociclib, PHA.793887, TG.02, indisulam, AZD5438, ribociclib, AT.7519, BMS.387032",1.7851561519523,0.815308569182401,TRUE
+"H358","Pearson.est","CHK inhibitor",0.22276,0.665,0.883,1127,1,"SCH.900776, CHIR.124, AZD7762, LY2603618, LY2606368, PF.477736, SB.218078",0.0540392964224314,0,FALSE
+"H358","Pearson.est","cyclooxygenase inhibitor",-0.25853,-0.621,0.905,992,0.969,"FR.122047, suxibuzone, meloxicam, piroxicam, aspirin, tryptanthrin, ketoprofen, phenazone",0.0433514207947967,0.0136762229492347,FALSE
+"H358","Pearson.est","cytochrome P450 inhibitor",-0.37365,-0.882,0.623,1191,0.848,"PF.4981517, morin",0.20551195334083,0.0716041477432862,FALSE
+"H358","Pearson.est","DNA alkylating agent",-0.36552,-0.891,0.599,1085,0.884,"cisplatin, streptozotocin, temozolomide, TH.302, estramustine",0.222573177610689,0.0535477349869269,FALSE
+"H358","Pearson.est","DNA inhibitor",-0.26063,-0.626,0.907,1286,0.98,"pibenzimol, primaquine",0.0423927129399047,0.00877392430750515,FALSE
+"H358","Pearson.est","DNA methyltransferase inhibitor",-0.40659,-0.987,0.503,774,0.803,"decitabine, fdcyd, RG108, SGI.1027, azacitidine",0.298432014944073,0.095284454721319,FALSE
+"H358","Pearson.est","DNA polymerase inhibitor",-0.58302,-1.41,0.0861,1199,0.332,"trifluridine, menadione, idoxuridine",1.06499684854635,0.478861916295964,FALSE
+"H358","Pearson.est","DNA synthesis inhibitor",0.25244,0.738,0.776,1086,1,"altretamine, artesunate, CB.10.277, nelarabine, cyclocytidine, floxuridine, mitomycin.c, anisomycin, azodicarbonamide, estramustine.phosphate, enocitabine, capecitabine, artemisinin, cisplatin",0.110138278741812,0,FALSE
+"H358","Pearson.est","dopamine receptor antagonist",-0.26209,-0.627,0.904,869,0.994,"amisulpride, isofloxythepin, nemonapride, acetophenazine, mesoridazine, piperacetazine, lurasidone, UH.232...., sertindole, paliperidone, ziprasidone",0.0438315695246367,0.00261361560268669,FALSE
+"H358","Pearson.est","estrogen receptor agonist",-0.64711,-1.56,0.0369,1327,0.182,"estradiol, PPT",1.43297363384094,0.739928612014925,TRUE
+"H358","Pearson.est","estrogen receptor antagonist",-0.78659,-1.9,0,1395,0.0642,"tamoxifen, clomifene",Inf,1.19246497193115,TRUE
+"H358","Pearson.est","FGFR inhibitor",-0.49966,-1.19,0.249,867,0.619,"dovitinib, regorafenib, MK.2461, orantinib, lucitanib, nintedanib, PD.173074",0.603800652904264,0.208309350979882,FALSE
+"H358","Pearson.est","FLT3 inhibitor",-0.46608,-1.12,0.313,844,0.747,"ponatinib, lestaurtinib, dovitinib, sunitinib, tozasertib, ENMD.2076, sorafenib, gilteritinib, KW.2449, tandutinib, TG.02, pacritinib",0.504455662453552,0.126679398184601,FALSE
+"H358","Pearson.est","glucocorticoid receptor agonist",-0.22492,-0.533,0.959,913,0.996,"fluocinolone.acetonide, halcinonide, prednisolone, prednisolone.hemisuccinate, methylprednisolone, difluprednate, halobetasol.propionate, betamethasone, flumethasone",0.0181813928293364,0.00174066157630127,FALSE
+"H358","Pearson.est","glutamate receptor antagonist",0.23572,0.662,0.877,56,1,"SIB.1757, MTPG",0.0570004066339595,0,FALSE
+"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.28496,-0.67,0.88,998,1,"indirubin, CHIR.99021, kenpaullone",0.0555173278498314,0,FALSE
+"H358","Pearson.est","growth factor receptor inhibitor",-0.58987,-1.42,0.101,850,0.351,"lestaurtinib, GSK1904529A, GW.441756, AZD3463, GSK1838705A, danusertib, PHA.848125",0.995678626217357,0.454692883534176,FALSE
+"H358","Pearson.est","HCV inhibitor",-0.67676,-1.62,0.0174,1169,0.138,"narlaprevir, daclatasvir, mericitabine",1.7594507517174,0.860120913598763,TRUE
+"H358","Pearson.est","HDAC inhibitor",-0.33364,-0.788,0.726,1031,0.952,"RGFP966, resminostat, dacinostat, belinostat, vorinostat, pyroxamide, M.344, RG2833, R306465",0.139063379299906,0.0213630516155257,FALSE
+"H358","Pearson.est","histamine receptor antagonist",-0.42032,-0.99,0.478,848,0.816,"pheniramine, lafutidine, ICI.162846, cimetidine, nizatidine, levocetirizine, astemizole, terfenadine, tiotidine, ebastine",0.320572103387881,0.0883098412461389,FALSE
+"H358","Pearson.est","HMGCR inhibitor",0.42857,1.18,0.294,830,0.689,"mevastatin, simvastatin, atorvastatin, fluvastatin, lovastatin, pitavastatin",0.531652669587843,0.161780778092374,FALSE
+"H358","Pearson.est","HSP inhibitor",-0.56906,-1.35,0.123,961,0.391,"ganetespib, BIIB021, PU.H71, NMS.E973, tanespimycin, NVP.AUY922, KW.2478, alvespimycin, SNX.5422, XL888",0.910094888560602,0.407823242604133,FALSE
+"H358","Pearson.est","JAK inhibitor",-0.54802,-1.31,0.145,965,0.416,"PRT062070, baricitinib, tozasertib, CEP.33779, AZD1480, atiprimod, AT.9283, AZ960, filgotinib, TG.101209, TG.02, pacritinib",0.838631997765025,0.380906669373257,FALSE
+"H358","Pearson.est","KIT inhibitor",-0.55078,-1.32,0.148,879,0.433,"motesanib, pazopanib, sunitinib, regorafenib, telatinib, vatalanib, sorafenib, imatinib, tandutinib, OSI.930, masitinib",0.829738284605043,0.363512103646635,FALSE
+"H358","Pearson.est","MDM inhibitor",-0.30837,-0.741,0.783,1170,0.967,"nutlin.3, CGM097",0.106238237942057,0.0145735259169983,FALSE
+"H358","Pearson.est","MEK inhibitor",0.19659,0.551,0.951,264,1,"U.0126, PD.318088, Ro.4987655, MEK162, MEK1.2.inhibitor, TAK.733, AZD8330",0.0218194830625861,0,FALSE
+"H358","Pearson.est","MET inhibitor",-0.39136,-0.945,0.542,1035,0.852,"INC.280, AMG458, PHA.665752",0.266000713461613,0.0695604052332999,FALSE
+"H358","Pearson.est","microtubule inhibitor",-0.5927,-1.41,0.0893,1354,0.332,"secnidazole, cytochalasin.b, D.64131",1.04914854111145,0.478861916295964,FALSE
+"H358","Pearson.est","mTOR inhibitor",0.18662,0.541,0.986,1183,0.969,"SB.2343, sirolimus, WAY.600, torin.1, PP242, PF.05212384, deforolimus, PKI.179, ku.0063794, PF.04691502, XL388, temsirolimus, GSK2126458, LY3023414, AZD2014, GDC.0980, everolimus, PI.103, voxtalisib, MLN0128, NVP.BEZ235, OSI.027, LY303511, WYE.354, AZD8055, WYE.125132, torin.2, palomid.529",0.0061230850587888,0.0136762229492347,FALSE
+"H358","Pearson.est","NFkB pathway inhibitor",-0.45847,-1.1,0.328,1320,0.751,"IKK.2.inhibitor.V, bortezomib, betulinic.acid",0.484126156288321,0.124360062995832,FALSE
+"H358","Pearson.est","opioid receptor agonist",-0.68806,-1.64,0.0249,1402,0.161,"salvinorin.a, trimebutine",1.60380065290426,0.79317412396815,TRUE
+"H358","Pearson.est","p38 MAPK inhibitor",-0.65522,-1.58,0.0309,1203,0.171,"skepinone.l, VX.702, SB.239063",1.51004152057517,0.767003889607846,TRUE
+"H358","Pearson.est","PARP inhibitor",-0.54165,-1.28,0.175,851,0.442,"talazoparib, AZD2461, niraparib, AG.14361, endo.IWR.1, PJ.34",0.756961951313706,0.354577730650908,FALSE
+"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49175,-1.18,0.255,844,0.622,"ponatinib, dovitinib, motesanib, pazopanib, sunitinib, regorafenib, telatinib, trapidil, orantinib, vatalanib, nintedanib, sorafenib, imatinib, tandutinib, masitinib, crenolanib, CP.673451",0.593459819566045,0.206209615309181,FALSE
+"H358","Pearson.est","phosphatase inhibitor",-0.37221,-0.908,0.583,1176,0.908,"GSK2830371, CID.5458317, menadione",0.234331445240986,0.0419141514789149,FALSE
+"H358","Pearson.est","phosphodiesterase inhibitor",-0.37579,-0.902,0.608,755,0.901,"avanafil, YM.976, papaverine, trequinsin, EMD.53998, cilostamide, GSK256066",0.216096420727265,0.045275209020937,FALSE
+"H358","Pearson.est","PI3K inhibitor",-0.20655,-0.494,0.975,636,0.981,"PI3K.IN.2, buparlisib, GSK2126458, ZSTK.474, pilaralisib, LY3023414, CUDC.907, GDC.0980, PI.103, voxtalisib, NVP.BEZ235, taselisib, LY303511, TG100.115, YM.201636, CH5132799, PIK.75, TG.100713",0.0109953843014632,0.0083309926200515,FALSE
+"H358","Pearson.est","PLK inhibitor",-0.43156,-1.03,0.421,1013,0.81,"volasertib, rigosertib, NMS.1286937",0.375717904164332,0.0915149811213502,FALSE
+"H358","Pearson.est","potassium channel blocker",-0.4089,-0.99,0.471,976,0.816,"oleoylethanolamide, ML133, mepivacaine",0.326979092871104,0.0883098412461389,FALSE
+"H358","Pearson.est","PPAR receptor agonist",0.37717,1.11,0.308,1,0.713,"pterostilbene",0.511449283499556,0.146910470148134,FALSE
+"H358","Pearson.est","progesterone receptor agonist",-0.20492,-0.494,0.985,1069,0.981,"dienogest, nomegestrol.acetate",0.00656376950238827,0.0083309926200515,FALSE
+"H358","Pearson.est","proteasome inhibitor",-0.44479,-1.06,0.4,920,0.781,"MG.132, oprozomib, ixazomib.citrate, carfilzomib, bortezomib",0.397940008672038,0.1073489661227,FALSE
+"H358","Pearson.est","protein synthesis inhibitor",0.2668,0.79,0.721,207,1,"clofoctol, brefeldin.a, clindamycin.phosphate, chloramphenicol.palmitate, mercaptopurine, emetine",0.142064735280571,0,FALSE
+"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.43403,-1.03,0.434,625,0.81,"rheochrysidin, PP.121, NVP.TAE226, tyrphostin.A9, mubritinib, CP.724714, BMS.599626, AV.412",0.362510270487489,0.0915149811213502,FALSE
+"H358","Pearson.est","RAF inhibitor",-0.5932,-1.44,0.0759,940,0.334,"regorafenib, PLX.4720, AZ.628, GDC.0879, RAF265, TAK.632, sorafenib, dabrafenib",1.11975822410452,0.476253533188435,FALSE
+"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.40923,-0.974,0.521,921,0.812,"sunitinib, regorafenib, sorafenib",0.283162276700476,0.0904439707588247,FALSE
+"H358","Pearson.est","retinoid receptor agonist",0.58811,1.71,0.0421,254,0.531,"adapalene, LE.135, AM.580, CD.437, fenretinide",1.37571790416433,0.274905478918531,FALSE
+"H358","Pearson.est","ribonucleotide reductase inhibitor",-0.28042,-0.668,0.868,974,0.987,"clofarabine, pentostatin, fludarabine.phosphate, fludarabine",0.0614802748235081,0.00568284733036327,FALSE
+"H358","Pearson.est","serotonin receptor agonist",-0.67443,-1.63,0.0253,1078,0.154,"pardoprunox, zolmitriptan, ipsapirone, aripiprazole",1.59687947882418,0.812479279163537,TRUE
+"H358","Pearson.est","serotonin receptor antagonist",-0.68252,-1.62,0.0185,1096,0.138,"lurasidone, sertindole, paliperidone, ziprasidone, SB.228357, SB.216641, RS.16566, aripiprazole",1.73282827159699,0.860120913598763,TRUE
+"H358","Pearson.est","sodium channel blocker",-0.32599,-0.78,0.748,987,0.946,"mepivacaine, ajmaline, triamterene, lappaconite, butamben, quinidine",0.126098402135539,0.0241088635982073,FALSE
+"H358","Pearson.est","src inhibitor",-0.7071,-1.69,0.00866,1216,0.167,"PP.2, TG.100572, saracatinib, masitinib, bosutinib, PP.1",2.06248210798265,0.777283528852417,TRUE
+"H358","Pearson.est","sterol demethylase inhibitor",0.42524,1.21,0.194,178,0.783,"lanoconazole, terconazole",0.712198270069774,0.106238237942057,FALSE
+"H358","Pearson.est","TGF beta receptor inhibitor",-0.75479,-1.8,0.0037,1290,0.096,"LY2109761, SB.431542, D.4476",2.431798275933,1.01772876696043,TRUE
+"H358","Pearson.est","thymidylate synthase inhibitor",-0.37319,-0.886,0.615,868,0.858,"raltitrexed, capecitabine, carmofur, trifluridine",0.211124884224583,0.0665127121512946,FALSE
+"H358","Pearson.est","topoisomerase inhibitor",0.56014,1.66,0.045,126,0.315,"epirubicin, TAS.103, beta.lapachone, nemorubicin, doxorubicin, exatecan.mesylate, voreloxin, camptothecin, mitoxantrone, rubitecan",1.34678748622466,0.501689446210399,FALSE
+"H358","Pearson.est","tubulin polymerization inhibitor",-0.31829,-0.757,0.784,1046,0.962,"ABT.751, nocodazole, docetaxel, parbendazole, fosbretabulin, vinorelbine, combretastatin.A.4, paclitaxel, albendazole",0.105683937315562,0.0168249279621871,FALSE
+"H358","Pearson.est","tyrosine kinase inhibitor",-0.37244,-0.889,0.61,687,0.87,"bafetinib, NVP.TAE226, apatinib, tyrphostin.A9, UNC2250, AMG.208, sunitinib, regorafenib, mubritinib, CP.724714, aminopurvalanol.a, sorafenib, BMS.599626, AV.412, tivantinib",0.214670164989233,0.0604807473813815,FALSE
+"H358","Pearson.est","VEGFR inhibitor",-0.45784,-1.11,0.324,867,0.749,"dovitinib, motesanib, BMS.690514, XL.647, pazopanib, sunitinib, regorafenib, MK.2461, telatinib, ENMD.2076, AEE788, tivozanib, orantinib, vatalanib, lucitanib, nintedanib, RAF265, sorafenib, TG.100572, OSI.930, PD.173074, foretinib, golvatinib",0.489454989793388,0.125518182300534,FALSE
+"H358","Pearson.est","vitamin D receptor agonist",-0.26314,-0.636,0.903,1007,1,"tacalcitol, alfacalcidol",0.0443122496864942,0,FALSE
+"H1650","Pearson.est","EGFR inhibitor",-0.2229,-0.599,0.907,1101,1,"rociletinib, vandetanib, PD.168393, WZ8040, gefitinib, tyrphostin.AG.1478, icotinib, brigatinib, ARRY.334543, WZ.4002, tyrphostin.AG.494, CNX.2006, BIBX.1382, CGP.52411",0.0423927129399047,0,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",-0.23747,-0.64,0.882,341,1,"flumatinib, KW.2449, ZM.306416, metatinib, ponatinib, bafetinib, bosutinib, tozasertib, dasatinib, nilotinib, GZD824, imatinib",0.0545314148681803,0,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.40807,1.04,0.383,320,0.727,"pilocarpine, xanomeline, nefiracetam",0.416801226031377,0.138465589140962,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",0.53125,1.37,0.157,19,0.964,"dicycloverine",0.804100347590766,0.0159229660971692,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",0.68678,1.77,0.0106,191,0.169,"PSB.1115, SCH.58261, theophylline",1.97469413473523,0.772113295386326,TRUE
+"H1650","Pearson.est","adrenergic receptor agonist",0.56493,1.5,0.0886,258,0.652,"clenbuterol, A61603, metaraminol, terbutaline, methyldopa, midodrine, buphenine",1.05256627811295,0.18575240426808,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.47274,1.22,0.226,200,0.802,"atenolol...., atenolol......, levobunolol, carvedilol, dronedarone, oxprenolol",0.645891560852599,0.0958256317158365,FALSE
+"H1650","Pearson.est","AKT inhibitor",-0.33646,-0.901,0.546,1391,1,"triciribine, ONC201",0.262807357295263,0,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.27869,0.704,0.794,92,1,"CEP.37440, DMH1",0.100179497572904,0,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",0.40748,1.02,0.439,25,0.685,"cyproterone.acetate",0.357535479757879,0.164309428507574,FALSE
+"H1650","Pearson.est","antioxidant",0.35173,0.9,0.553,23,0.779,"taurine",0.257274868695302,0.108462542327436,FALSE
+"H1650","Pearson.est","AP inhibitor",-0.34018,-0.908,0.569,1323,1,"birinapant",0.244887733604929,0,FALSE
+"H1650","Pearson.est","ATPase inhibitor",-0.40193,-1.07,0.363,1310,0.861,"digitoxigenin, oligomycin.a, k.strophanthidin",0.440093374963888,0.0649968485463452,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",-0.17814,-0.483,0.977,379,0.983,"KW.2449, SNS.314, ZM.447439, danusertib, MK.8745, alisertib, PHA.680632, CCT137690, PF.03814735, hesperadin, AMG900, CCT129202, GSK1070916, ENMD.2076, AT.9283, tozasertib, barasertib, aurora.a.inhibitor.i, MK.5108, TAK.901, MLN.8054, CYC116",0.0101054362812269,0.00744648216786438,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.47257,1.21,0.232,190,0.724,"azithromycin, dirithromycin, josamycin",0.6345120151091,0.140261433802853,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.4375,1.1,0.335,273,0.806,"sparfloxacin, trovafloxacin, sarafloxacin",0.474955192963155,0.0936649581949093,FALSE
+"H1650","Pearson.est","BCL inhibitor",-0.44463,-1.21,0.228,1082,0.785,"venetoclax, gossypol, HA14.1, obatoclax",0.642065152999546,0.105130343254747,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",-0.33975,-0.899,0.546,1026,1,"dasatinib, nilotinib, GZD824, imatinib",0.262807357295263,0,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",0.3913,1.01,0.445,389,0.679,"piperazine, temazepam, gamma.aminobutyric.acid, nefiracetam, indiplon, CL.218872, ZK.93423",0.351639989019068,0.168130225719498,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.76843,1.99,0.00538,268,0.0651,"I.BET.762, I.BET151, JQ1...., PFI.1, bromosporine",2.26921772433361,1.18641901143181,TRUE
+"H1650","Pearson.est","calcium channel blocker",0.26941,0.687,0.829,418,1,"SKF.96365, penfluridol, fendiline, efonidipine.monoethanolate, mibefradil",0.0814454694497265,0,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",-0.22447,-0.588,0.935,1148,0.981,"ZK811752, navarixin",0.0291883891274822,0.0083309926200515,FALSE
+"H1650","Pearson.est","CDK inhibitor",0.25692,0.656,0.855,515,0.991,"P276.00, JNJ.7706621, dinaciclib, AZD5438, AT.7519, aminopurvalanol.a, alvocidib, BMS.387032, PHA.793887",0.0680338852718274,0.00392634551472468,FALSE
+"H1650","Pearson.est","CHK inhibitor",-0.54508,-1.43,0.142,1252,0.603,"LY2603618, CHIR.124, SCH.900776",0.847711655616944,0.219682687859849,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",-0.24088,-0.648,0.856,1191,1,"AM.404, meloxicam, acetylsalicylsalicylic.acid, pterostilbene, tepoxalin, curcumin, FR.122047",0.0675262353228468,0,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",0.40554,1.04,0.391,29,0.727,"morin",0.407823242604133,0.138465589140962,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.38856,0.981,0.459,262,0.705,"estramustine, carmustine, ifosfamide, melphalan, mitomycin.c",0.338187314462739,0.151810883008601,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.22987,0.583,0.932,322,0.993,"carmustine, bendamustine, melphalan, primaquine",0.0305840876460186,0.00305075150461883,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.48665,1.23,0.229,154,0.838,"fdcyd, SGI.1027",0.640164517660112,0.0767559813697235,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",0.48552,1.25,0.215,63,0.928,"trifluridine",0.667561540084395,0.0324520237811379,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",-0.39825,-1.07,0.36,1305,0.861,"estramustine.phosphate, CB.10.277, altretamine, artesunate",0.443697499232713,0.0649968485463452,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",0.28715,0.739,0.787,293,0.978,"isofloxythepin, lurasidone, sertindole, paliperidone, acetophenazine, amisulpride, ziprasidone",0.104025267640935,0.00966114521239857,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",0.30558,0.788,0.698,461,0.948,"estradiol, levonorgestrel, erteberel, ethinyl.estradiol",0.156144577376839,0.0231916626619338,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",0.41106,1.05,0.384,403,0.801,"clomifene, toremifene, tamoxifen",0.415668775632469,0.0963674839157623,FALSE
+"H1650","Pearson.est","FGFR inhibitor",-0.25052,-0.663,0.86,1434,1,"AZD4547",0.0655015487564323,0,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",-0.28693,-0.782,0.706,1102,1,"quizartinib, pacritinib, sunitinib, GTP.14564, midostaurin, lestaurtinib, tyrphostin.AG.1296",0.151195298948196,0,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",-0.46503,-1.22,0.239,1056,0.838,"beclomethasone.dipropionate, prednisolone, clobetasol.propionate, triamcinolone, prednisolone.acetate, flumethasone.pivalate, halcinonide, rimexolone, desonide, ciclesonide, dexamethasone.acetate, fluocinolone.acetonide, triamcinolone.acetonide, hydrocortisone",0.621602099051862,0.0767559813697235,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",-0.22013,-0.587,0.925,1161,0.953,"CGP.37849, tiletamine, latrepirdine, SIB.1757",0.0338582672609674,0.0209070993616736,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.26623,-0.712,0.771,876,1,"CHIR.98014, AZD2858, tideglusib, GSK.3.inhibitor.IX, indirubin, TWS.119",0.112945621949043,0,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.41979,1.08,0.365,413,0.81,"GSK1838705A, GW.441756, GSK1904529A, danusertib",0.437707135543525,0.0915149811213502,FALSE
+"H1650","Pearson.est","HCV inhibitor",-0.58746,-1.59,0.0662,1318,0.582,"PSI.7976, narlaprevir",1.1791420105603,0.235077015350112,FALSE
+"H1650","Pearson.est","HDAC inhibitor",-0.23103,-0.617,0.897,1369,1,"JNJ.26481585, romidepsin, ACY.1215",0.0472075569559079,0,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",0.39227,1.02,0.415,472,0.685,"cimetidine, cyproheptadine, pheniramine, zolantidine, ranitidine, tiotidine, ebastine, terfenadine",0.381951903287907,0.164309428507574,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.80444,-2.08,0,1160,0.0937,"fluvastatin, mevastatin, atorvastatin, pitavastatin, lovastatin, simvastatin",Inf,1.02826040911222,TRUE
+"H1650","Pearson.est","HSP inhibitor",-0.25155,-0.675,0.862,1143,1,"guanidine, NVP.AUY922, ganetespib, BIIB021",0.0644927341752872,0,FALSE
+"H1650","Pearson.est","JAK inhibitor",0.18985,0.485,0.978,176,1,"AZD1480, WHI.P154",0.00966114521239857,0,FALSE
+"H1650","Pearson.est","KIT inhibitor",-0.25269,-0.663,0.848,1186,1,"masitinib, sunitinib, lenvatinib, midostaurin, imatinib",0.0716041477432862,0,FALSE
+"H1650","Pearson.est","MDM inhibitor",-0.75345,-1.97,0.00948,1235,0.127,"CGM097, AMG.232, idasanutlin, RITA",2.02319166266193,0.896196279044043,TRUE
+"H1650","Pearson.est","MEK inhibitor",-0.39159,-1.04,0.391,989,0.877,"AS.703026, selumetinib, U.0126, PD.0325901, Ro.4987655, PD.198306, PD.184352, MEK162, AZD8330, TAK.733, PD.318088, refametinib",0.407823242604133,0.0570004066339595,FALSE
+"H1650","Pearson.est","MET inhibitor",0.47869,1.24,0.239,206,0.879,"AMG458, INC.280, PHA.665752",0.621602099051862,0.0560111249262281,FALSE
+"H1650","Pearson.est","microtubule inhibitor",-0.22285,-0.597,0.924,1093,1,"cabazitaxel, secnidazole, colchicine, estramustine.phosphate",0.0343280287798933,0,FALSE
+"H1650","Pearson.est","mTOR inhibitor",-0.52921,-1.4,0.137,1111,0.588,"GDC.0980, OSI.027, MLN0128, WAY.600, WYE.354, XL388, NVP.BEZ235, deforolimus, GSK2126458, PKI.179, PP242, PF.05212384, torin.1, sirolimus, SB.2343",0.863279432843593,0.230622673923862,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",-0.28794,-0.802,0.644,1085,1,"tyloxapol, parthenolide...., BAY.11.7085, EVP4593, curcumin",0.191114132640188,0,FALSE
+"H1650","Pearson.est","opioid receptor agonist",-0.26491,-0.697,0.804,382,1,"trimebutine, ADL5859, spiradoline, salvinorin.a, cebranopadol, BW.180C",0.0947439512515487,0,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.47436,1.21,0.246,305,0.724,"SB.239063, SB.242235, talmapimod",0.609064892896621,0.140261433802853,FALSE
+"H1650","Pearson.est","PARP inhibitor",0.40416,1.03,0.431,373,0.718,"olaparib, talazoparib, PJ.34",0.365522729839268,0.1438755557577,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30102,-0.803,0.678,1186,1,"masitinib, sunitinib, lenvatinib, axitinib, imatinib, linifanib",0.168770306132937,0,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",0.35205,0.901,0.582,289,0.801,"AS.1949490, GSK2830371, mycophenolate.mofetil, mycophenolic.acid",0.235077015350112,0.0963674839157623,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",0.46814,1.2,0.237,324,0.703,"cilostamide, zardaverine, trequinsin, YM.976, papaverine, avanafil",0.625251653989896,0.153044674980176,FALSE
+"H1650","Pearson.est","PI3K inhibitor",-0.45061,-1.2,0.252,1247,0.685,"CUDC.907, pilaralisib, NVP.BEZ235, GSK2126458, PKI.179, YM.201636, PF.05212384, GDC.0941, SB.2343",0.598599459218456,0.164309428507574,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.77018,1.99,0.00532,167,0.0651,"volasertib, GW.843682X, BI.2536, NMS.1286937",2.27408836770495,1.18641901143181,TRUE
+"H1650","Pearson.est","potassium channel blocker",0.35506,0.906,0.567,936,0.817,"dofetilide, ML133, ibutilide, oleoylethanolamide, mepivacaine, meglitinide",0.246416941107093,0.0877779434675845,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",-0.54729,-1.45,0.105,1272,0.655,"pterostilbene, clofibrate",0.978810700930062,0.183758700008217,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",-0.32815,-0.865,0.621,1239,1,"norethindrone, norgestrel, tanaproget",0.20690839982342,0,FALSE
+"H1650","Pearson.est","proteasome inhibitor",0.49375,1.27,0.2,737,0.957,"bortezomib, MG.132, delanzomib, ONX.0914, ixazomib, carfilzomib, oprozomib, ixazomib.citrate",0.698970004336019,0.0190880622231565,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.26045,0.657,0.867,211,1,"puromycin, azomycin..2.nitroimidazole., anguidine, tedizolid.phosphate",0.0619809025237897,0,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.43434,1.12,0.313,555,0.845,"CP.724714, AV.412, BMS.599626, PP.121, NVP.TAE226",0.504455662453552,0.0731432910503077,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.4941,1.27,0.213,422,0.957,"GDC.0879, dabrafenib, vemurafenib, PLX.4720, sorafenib, RAF265, TAK.632",0.671620396561262,0.0190880622231565,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.47084,-1.28,0.184,1108,0.776,"vandetanib, cabozantinib, sunitinib, apatinib",0.735182176990464,0.110138278741812,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.71853,1.85,0.0119,33,0.108,"adarotene, tamibarotene, AM.580",1.92445303860747,0.96657624451305,TRUE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.41244,1.04,0.385,182,0.727,"fludarabine, pentostatin",0.414539270491499,0.138465589140962,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",-0.4531,-1.2,0.244,1446,0.685,"aripiprazole",0.612610173661271,0.164309428507574,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",0.50834,1.3,0.204,344,1,"lurasidone, sertindole, pirenperone, paliperidone, SB.216641, RS.16566, lerisetron, ziprasidone, SB.228357, SB.200646",0.690369832574101,0,FALSE
+"H1650","Pearson.est","sodium channel blocker",0.42871,1.11,0.334,84,0.825,"butamben, lappaconite",0.476253533188435,0.0835460514500749,FALSE
+"H1650","Pearson.est","src inhibitor",0.4206,1.06,0.392,277,0.816,"TG.100572, PP.1, PP.2",0.406713932979543,0.0883098412461389,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",-0.59326,-1.58,0.0692,1033,0.486,"terconazole, sulconazole, lanoconazole, ketoconazole",1.15989390554324,0.313363730737707,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",0.24429,0.617,0.921,385,1,"LY2109761, D.4476",0.0357403698031511,0,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.74562,1.93,0.00534,98,0.0739,"trifluridine, raltitrexed, doxifluridine",2.27245874297144,1.13135556160517,TRUE
+"H1650","Pearson.est","topoisomerase inhibitor",0.29485,0.763,0.74,193,0.965,"exatecan.mesylate, genz.644282, etoposide.phosphate, dexrazoxane, topotecan, licochalcone.a",0.130768280269024,0.0154726866562074,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.15885,0.404,0.997,992,0.997,"albendazole, parbendazole, fenbendazole, paclitaxel, nocodazole, taltobulin, vinorelbine, flubendazole, ABT.751, CYT.997, dolastatin.10, combretastatin.A.4, docetaxel, oxibendazole, fosbretabulin, vincristine, indibulin, vindesine, KX2.391, mebendazole, podophyllotoxin, epothilone.b, BNC105, vinblastine, verubulin",0.00130484168834428,0.00130484168834428,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.23946,0.599,0.925,97,1,"tivantinib, hypericin, CP.724714",0.0338582672609674,0,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.1687,0.427,0.997,269,1,"lucitanib, TG.100572, foretinib, golvatinib, PD.173074, pazopanib, OSI.930",0.00130484168834428,0,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.70191,-1.85,0.0145,1170,0.202,"tacalcitol, alfacalcidol, doxercalciferol, paricalcitol, calcitriol",1.83863199776503,0.694648630553376,TRUE
+"HCC95","Pearson.est","EGFR inhibitor",0.20896,0.565,0.973,422,1,"CUDC.101, AST.1306, AZD8931, BMS.690514, dovitinib, gefitinib, XL.647, ARRY.334543, poziotinib, dacomitinib, tyrphostin.AG.494, WZ.3146, BIBX.1382, BIBU.1361, tucatinib",0.0118871597316481,0,FALSE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.68685,-1.65,0.0264,1028,0.196,"GZD824, flumatinib, KW.2449, bosutinib, ponatinib, metatinib, nilotinib, imatinib, tozasertib",1.57839607313017,0.707743928643524,TRUE
+"HCC95","Pearson.est","acetylcholine receptor agonist",-0.44279,-1.09,0.345,1389,0.743,"nicotine",0.462180904926726,0.129011186239425,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.29163,-0.717,0.814,1012,0.906,"dicycloverine, iododexetimide",0.0893755951107988,0.0428718023231869,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",0.36837,0.999,0.423,168,0.878,"SCH.58261, PSB.1115",0.373659632624958,0.0565054840938974,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",-0.31359,-0.763,0.761,1386,0.897,"epinephrine, terbutaline",0.118615343229427,0.0472075569559079,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",0.5372,1.42,0.12,108,1,"propranolol, prazosin, practolol, levobunolol, atenolol......, atenolol....",0.920818753952375,0,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.37586,-0.91,0.541,825,0.832,"MK.2206, A.674563, AT7867, GSK2110183, triciribine, AZD5363",0.266802734893431,0.0798766737092761,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25605,-0.607,0.914,1225,0.952,"alectinib, AZD3463, AP26113",0.0390538042661686,0.0213630516155257,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",0.58495,1.58,0.0831,164,0.914,"enzalutamide, bicalutamide",1.08039897621589,0.0390538042661686,FALSE
+"HCC95","Pearson.est","antioxidant",-0.4151,-0.999,0.471,882,0.777,"mesna, trolox, rutin, chlorogenic.acid",0.326979092871104,0.109578981199086,FALSE
+"HCC95","Pearson.est","AP inhibitor",-0.31367,-0.769,0.724,1065,0.908,"idronoxil, LCL.161",0.140261433802853,0.0419141514789149,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",0.42206,1.14,0.322,71,0.701,"k.strophanthidin, evodiamine",0.492144128304169,0.154281982033341,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",-0.7399,-1.79,0.00714,1163,0.175,"SNS.314, KW.2449, GSK1070916, alisertib, PF.03814735, MLN.8054, MK.5108, TAK.901, MK.8745, AT.9283, AMG900, tozasertib, hesperadin, CYC116",2.14630178822383,0.756961951313706,TRUE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26562,0.724,0.794,159,0.969,"josamycin, azithromycin",0.100179497572904,0.0136762229492347,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.5136,1.34,0.155,358,0.702,"finafloxacin, trovafloxacin, norfloxacin, nadifloxacin, sparfloxacin",0.809668301829709,0.153662887870195,FALSE
+"HCC95","Pearson.est","BCL inhibitor",-0.48092,-1.17,0.277,946,0.653,"venetoclax, obatoclax, HA14.1, ABT.737, TW.37, gossypol",0.557520230935551,0.185086818724926,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.68918,-1.67,0.027,1028,0.224,"GZD824, flumatinib, bosutinib, ponatinib, metatinib, nilotinib, imatinib, tozasertib",1.56863623584101,0.649751981665837,TRUE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",0.45644,1.23,0.22,280,0.653,"eprinomectin, gamma.aminobutyric.acid, ZK.93423, CL.218872, piperazine, indiplon, bentazepam",0.657577319177794,0.185086818724926,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",-0.61288,-1.49,0.068,1096,0.417,"PFI.1, bromosporine, OTX015",1.16749108729376,0.379863945026242,FALSE
+"HCC95","Pearson.est","calcium channel blocker",0.40972,1.11,0.3,142,0.703,"SKF.96365, efonidipine.monoethanolate",0.522878745280338,0.153044674980176,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.28266,-0.674,0.866,1354,0.902,"navarixin",0.0624821079826534,0.0447934624580583,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.38519,-0.939,0.517,1146,0.821,"dinaciclib, BMS.265246, arcyriaflavin.a, ribociclib, palbociclib, abemaciclib, aminopurvalanol.a",0.286509456906058,0.0856568428805592,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.78913,-1.91,0.00296,1418,0.161,"SCH.900776, LY2603618, LY2606368, AZD7762",2.52870828894106,0.79317412396815,TRUE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.22212,-0.543,0.962,987,0.977,"ketoprofen, metoxibutropate, piroxicam, indoprofen, tepoxalin, FR.122047, acetylsalicylsalicylic.acid",0.0168249279621871,0.0101054362812269,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.45632,1.26,0.204,19,0.673,"morin",0.690369832574101,0.171984935776023,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.38497,-0.94,0.504,1077,0.843,"dianhydrogalactitol, cyclophosphamide, streptozotocin, satraplatin, melphalan, mitomycin.c",0.297569463554475,0.0741724253752577,FALSE
+"HCC95","Pearson.est","DNA inhibitor",0.35148,0.94,0.497,191,0.786,"mechlorethamine, sangivamycin, metronidazole, tirapazamine, bendamustine, carmustine, nithiamide",0.303643611266668,0.104577453960592,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.28763,-0.7,0.804,1106,0.908,"RG108, decitabine",0.0947439512515487,0.0419141514789149,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",0.50254,1.35,0.155,137,0.815,"foscarnet, famciclovir",0.809668301829709,0.0888423912600234,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.55736,-1.34,0.148,1200,0.597,"floxuridine, anisomycin, cyclocytidine, CB.10.277, enocitabine, mitomycin.c",0.829738284605043,0.224025668870631,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",0.32266,0.864,0.59,296,0.801,"sertindole, isofloxythepin, clebopride, thioproperazine, mesoridazine, domperidone, lurasidone, ziprasidone",0.229147988357856,0.0963674839157623,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.30443,-0.744,0.796,1167,0.907,"PPT, estradiol",0.0990869322623309,0.0423927129399047,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",-0.33675,-0.818,0.668,998,0.958,"raloxifene, danazol, fulvestrant",0.175223537524454,0.0186344909214556,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",-0.31522,-0.773,0.763,1283,0.923,"nintedanib, AZD4547",0.11747546204512,0.0347982989740879,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",-0.53046,-1.28,0.19,1135,0.623,"gilteritinib, KW.2449, ponatinib, sunitinib, quizartinib, tozasertib, midostaurin, lestaurtinib",0.721246399047171,0.20551195334083,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",0.16866,0.447,0.997,1208,0.995,"hydrocortisone, piretanide, triamcinolone.acetonide, betamethasone, dexamethasone.acetate, prednisolone.hemisuccinate, methylprednisolone, ciclesonide, desonide, deflazacort, fludroxycortide, flumethasone, difluprednate, halobetasol.propionate, rimexolone, flumethasone.pivalate, triamcinolone, clobetasol.propionate, halcinonide, prednisolone.acetate, prednisolone, fluticasone.propionate, beclomethasone.dipropionate, fluocinolone.acetonide, fluorometholone",0.00130484168834428,0.00217691925427455,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",0.35553,0.966,0.512,166,0.779,"ACDPP, felbamate, kynurenic.acid, latrepirdine",0.290730039024169,0.108462542327436,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.17931,0.483,0.993,84,1,"CHIR.98014",0.00305075150461883,0,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.56,-1.36,0.135,1293,0.589,"AZD3463, lestaurtinib",0.869666231504994,0.229884705212898,FALSE
+"HCC95","Pearson.est","HCV inhibitor",0.34039,0.919,0.509,70,0.782,"daclatasvir",0.293282217663241,0.106793246940152,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.69958,-1.71,0.0162,1233,0.251,"M.344, belinostat, PCI.24781, romidepsin, tacedinaline, AR.42, ACY.1215, resminostat, trichostatin.a, SB.939, JNJ.26481585, givinostat, entinostat, mocetinostat, dacinostat, RG2833",1.79048498545737,0.600326278518962,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",-0.28322,-0.691,0.832,1376,0.902,"tiotidine, BF2.649",0.0798766737092761,0.0447934624580583,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",-0.42061,-1.02,0.428,938,0.785,"pitavastatin, simvastatin",0.368556230986828,0.105130343254747,FALSE
+"HCC95","Pearson.est","HSP inhibitor",-0.38972,-0.942,0.509,1175,0.863,"BIIB021, NVP.AUY922, ganetespib, VER.49009",0.293282217663241,0.0639892042847904,FALSE
+"HCC95","Pearson.est","JAK inhibitor",-0.52588,-1.26,0.193,1331,0.632,"AZ960, AT.9283, tozasertib, lestaurtinib, PRT062070",0.714442690992226,0.199282921717615,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.5752,-1.4,0.106,1324,0.54,"KI.8751, telatinib, sunitinib, imatinib, midostaurin, vatalanib",0.97469413473523,0.267606240177031,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.42895,1.17,0.262,449,0.706,"idasanutlin, AMG.232, nutlin.3, serdemetan",0.581698708680255,0.151195298948196,FALSE
+"HCC95","Pearson.est","MEK inhibitor",-0.45922,-1.12,0.337,960,0.705,"PD.98059, AS.703026, refametinib, trametinib, cobimetinib, selumetinib, Ro.4987655, MEK162, AZD8330, nobiletin, PD.184352, TAK.733",0.472370099128661,0.151810883008601,FALSE
+"HCC95","Pearson.est","MET inhibitor",-0.5044,-1.22,0.233,740,0.657,"LY2801653, INC.280, PHA.665752, NVP.BVU972, PF.04217903",0.632644078973981,0.182434630440219,FALSE
+"HCC95","Pearson.est","microtubule inhibitor",-0.54361,-1.31,0.171,840,0.626,"estramustine.phosphate, colchicine, vinblastine, vinflunine, podophyllotoxin, secnidazole, cytochalasin.b, cabazitaxel, D.64131",0.767003889607846,0.20342566678957,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",0.26069,0.723,0.799,352,0.929,"AZD8055, torin.1, voxtalisib, AZD2014, WYE.125132, palomid.529, OSI.027, PP242, WYE.354, PF.05212384, PF.04691502, ku.0063794",0.0974532206860086,0.0319842860063582,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",-0.22102,-0.533,0.962,1288,0.965,"Ro.106.9920, BAY.11.7082",0.0168249279621871,0.0154726866562074,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",0.3516,0.981,0.459,941,0.856,"spiradoline, trimebutine, salvinorin.a, ADL5859, cebranopadol, BW.180C",0.338187314462739,0.0675262353228468,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",0.61886,1.71,0.0345,242,1,"SB.242235, talmapimod, skepinone.l, SB.239063",1.46218090492673,0,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.41484,-1.01,0.431,894,0.781,"AZD2461, niraparib, olaparib, talazoparib",0.365522729839268,0.1073489661227,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.50591,-1.23,0.229,1204,0.667,"ponatinib, SU014813, nintedanib, KI.8751, telatinib, sunitinib, imatinib, axitinib, vatalanib",0.640164517660112,0.175874166083451,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.36448,0.98,0.443,205,0.801,"sodium.stibogluconate, alexidine, GSK2830371",0.35359627377693,0.0963674839157623,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",-0.38191,-0.923,0.547,1266,0.829,"trequinsin, GSK256066",0.262012673666569,0.0814454694497265,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.30666,-0.734,0.772,1122,0.902,"TG100.115, PIK.75, GDC.0980, alpelisib, CUDC.907, SB.2343, taselisib, ZSTK.474",0.112382699664264,0.0447934624580583,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.6799,-1.66,0.026,1141,0.208,"volasertib, GW.843682X, rigosertib, BI.2536, GSK461364",1.58502665202918,0.681936665037238,TRUE
+"HCC95","Pearson.est","potassium channel blocker",-0.42942,-1.04,0.424,1298,0.768,"mepivacaine, meglitinide",0.372634143407267,0.114638779968488,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.29476,0.821,0.656,300,0.839,"pterostilbene, ciprofibrate, S26948",0.18309616062434,0.0762380391712997,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",-0.32419,-0.79,0.727,800,0.938,"tanaproget, nomegestrol.acetate, melengestrol.acetate, norethindrone.acetate, danazol",0.138465589140962,0.0277971616209356,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",-0.47918,-1.19,0.251,1063,0.698,"carfilzomib, ixazomib, ixazomib.citrate",0.600326278518962,0.156144577376839,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",-0.32311,-0.788,0.725,889,0.919,"thiostrepton, mercaptopurine, chloramphenicol.palmitate, bruceantin, cycloheximide, anguidine, clindamycin.phosphate, homoharringtonine, puromycin, emetine",0.139661993429006,0.0366844886138887,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.42709,-1.04,0.409,1132,0.768,"rheochrysidin, NVP.TAE226, AV.412",0.388276691992658,0.114638779968488,FALSE
+"HCC95","Pearson.est","RAF inhibitor",-0.33041,-0.81,0.685,1302,0.949,"AZ.628, CEP.32496, TAK.632",0.164309428507574,0.0227337875727074,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.4864,-1.17,0.284,975,0.653,"regorafenib, cabozantinib, sunitinib",0.546681659952962,0.185086818724926,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",0.48297,1.26,0.215,310,0.673,"adapalene, bexarotene, tamibarotene, adarotene",0.667561540084395,0.171984935776023,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.52132,-1.28,0.195,988,0.623,"triapine, hydroxyurea, cladribine, fludarabine, LY2334737, gemcitabine, clofarabine",0.709965388637482,0.20551195334083,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.76382,-1.86,0.00439,1447,0.138,"aripiprazole",2.35753547975788,0.860120913598763,TRUE
+"HCC95","Pearson.est","serotonin receptor antagonist",-0.49193,-1.18,0.262,1317,0.689,"tropisetron, RS.16566, aripiprazole",0.581698708680255,0.161780778092374,FALSE
+"HCC95","Pearson.est","sodium channel blocker",0.24209,0.678,0.876,430,0.952,"brivaracetam, ajmaline, A.803467, lappaconite, benzocaine, mexiletine, cibenzoline",0.0574958938319193,0.0213630516155257,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.46773,-1.14,0.316,1073,0.69,"masitinib, bosutinib, KX2.391",0.500312917381596,0.161150909262745,FALSE
+"HCC95","Pearson.est","sterol demethylase inhibitor",0.3218,0.871,0.611,303,0.828,"sulconazole, posaconazole, chlormidazole, terconazole",0.213958789757446,0.0819696632151199,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",0.52407,1.41,0.135,66,0.838,"LY2109761",0.869666231504994,0.0767559813697235,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.33188,-0.807,0.697,698,0.931,"carmofur, raltitrexed, capecitabine, doxifluridine",0.156767221901991,0.0310503190186574,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",-0.68355,-1.69,0.0236,1187,0.235,"valrubicin, rubitecan, irinotecan, doxorubicin, licochalcone.a, exatecan.mesylate, mitoxantrone, amonafide, genz.644282, voreloxin, amsacrine, etoposide, camptothecin, TAS.103, daunorubicin, teniposide",1.62708799702989,0.628932137728264,TRUE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.59853,-1.46,0.101,1036,0.442,"vindesine, albendazole, podophyllotoxin, BNC105, fenbendazole, paclitaxel, vincristine, fosbretabulin, oxibendazole, ABT.751, verubulin, parbendazole, CYT.997, epothilone.b, docetaxel, dolastatin.10, combretastatin.A.4, KX2.391, plinabulin, epothilone.d",0.995678626217357,0.354577730650908,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.44581,-1.08,0.355,1132,0.737,"rheochrysidin, NVP.TAE226, AV.412, tyrphostin.AG.99, AMG.208, UNC2250, sunitinib, aminopurvalanol.a",0.449771646944906,0.132532512140949,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.36418,-0.896,0.576,1259,0.837,"SU014813, foretinib, nintedanib, KI.8751, telatinib, sunitinib, axitinib, vatalanib",0.239577516576788,0.07727454200674,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",-0.61771,-1.51,0.0616,1081,0.418,"paricalcitol, doxercalciferol, alfacalcidol, calcitriol, tacalcitol",1.21041928783557,0.378823718224965,FALSE
+"H3255","Pearson.est","EGFR inhibitor",0.54273,1.42,0.12,174,0.385,"BMS.599626, tucatinib, CUDC.101, CP.724714, AEE788, BMS.690514, lapatinib, AZD8931, neratinib, AST.1306, WZ.4002, salvianolic.acid.B, dovitinib",0.920818753952375,0.414539270491499,FALSE
+"H3255","Pearson.est","Abl kinase inhibitor",0.46027,1.17,0.275,371,0.435,"imatinib, flumatinib, ZM.306416, metatinib, dasatinib",0.560667306169737,0.361510743045363,FALSE
+"H3255","Pearson.est","acetylcholine receptor agonist",0.35116,0.912,0.583,30,0.671,"oxiracetam",0.234331445240986,0.173277479831008,FALSE
+"H3255","Pearson.est","acetylcholine receptor antagonist",-0.29795,-0.772,0.733,1045,1,"dicycloverine, methscopolamine, iododexetimide",0.134896025358872,0,FALSE
+"H3255","Pearson.est","adenosine receptor antagonist",0.62569,1.62,0.04,389,0.462,"CGS.15943, sulmazole, SCH.58261, istradefylline, PSB.1115, MRS.1220",1.39794000867204,0.335358024443874,FALSE
+"H3255","Pearson.est","adrenergic receptor agonist",-0.41907,-1.1,0.324,1269,0.664,"A61603, epinephrine, terbutaline, norepinephrine",0.489454989793388,0.177831920631982,FALSE
+"H3255","Pearson.est","adrenergic receptor antagonist",0.51416,1.31,0.179,352,0.412,"practolol, atenolol...., RS.17053, dihydroergocristine, prazosin, dronedarone, pindolol, imiloxan",0.747146969020107,0.385102783966865,FALSE
+"H3255","Pearson.est","AKT inhibitor",-0.27502,-0.711,0.802,1236,1,"GSK2110183, GDC.0068, MK.2206",0.0958256317158365,0,FALSE
+"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.48859,1.27,0.207,254,0.41,"SB.505124, DMH1, AZD3463, NVP.TAE684, GW.788388",0.684029654543082,0.387216143280265,FALSE
+"H3255","Pearson.est","androgen receptor antagonist",-0.28988,-0.763,0.735,418,1,"bicalutamide, cyproterone.acetate, RU.58841, flutamide, nilutamide, enzalutamide",0.133712660915805,0,FALSE
+"H3255","Pearson.est","antioxidant",0.47298,1.23,0.221,195,0.413,"trolox, taurine",0.655607726314889,0.384049948343599,FALSE
+"H3255","Pearson.est","AP inhibitor",0.46936,1.18,0.259,22,0.451,"tanshinone.i",0.586700235918748,0.345823458122039,FALSE
+"H3255","Pearson.est","ATPase inhibitor",0.40295,1.01,0.423,234,0.554,"digoxin, ouabain, oligomycin.a, evodiamine",0.373659632624958,0.25649023527157,FALSE
+"H3255","Pearson.est","Aurora kinase inhibitor",-0.22609,-0.573,0.943,1079,1,"CYC116, AMG900, aurora.a.inhibitor.i, MK.5108, GSK1070916, MLN.8054",0.0254883072626717,0,FALSE
+"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.54322,1.4,0.122,293,0.39,"azalomycin.b, tedizolid, radezolid, tilmicosin, josamycin, valnemulin",0.913640169325252,0.408935392973501,FALSE
+"H3255","Pearson.est","bacterial DNA gyrase inhibitor",-0.62744,-1.67,0.0513,963,0.458,"nadifloxacin, novobiocin, norfloxacin, sparfloxacin, lomefloxacin, finafloxacin",1.28988263488818,0.339134521996131,FALSE
+"H3255","Pearson.est","BCL inhibitor",-0.47582,-1.25,0.221,1322,0.602,"TW.37, HA14.1",0.655607726314889,0.220403508742175,FALSE
+"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.4576,1.17,0.284,371,0.435,"imatinib, flumatinib, metatinib, dasatinib",0.546681659952962,0.361510743045363,FALSE
+"H3255","Pearson.est","benzodiazepine receptor agonist",0.44467,1.12,0.314,33,0.46,"ZK.93423, eprinomectin",0.503070351926785,0.337242168318426,FALSE
+"H3255","Pearson.est","bromodomain inhibitor",0.31415,0.786,0.709,995,0.774,"I.BET.762, JQ1...., I.BET151, PFI.1, OTX015, bromosporine",0.149353764816933,0.111259039317107,FALSE
+"H3255","Pearson.est","calcium channel blocker",0.56981,1.47,0.0824,420,0.395,"SKF.96365, tetrandrine, cinnarazine, efonidipine.monoethanolate, fendiline, carboxyamidotriazole, penfluridol",1.08407278830288,0.40340290437354,FALSE
+"H3255","Pearson.est","CC chemokine receptor antagonist",0.40679,1.05,0.379,427,0.512,"SB.225002, RS.504393, PF.04136309",0.421360790031928,0.290730039024169,FALSE
+"H3255","Pearson.est","CDK inhibitor",0.62229,1.57,0.0624,182,0.433,"BMS.387032, AT.7519, PHA.793887, JNJ.7706621, R547, CR8..R., indisulam, palbociclib, arcyriaflavin.a, ribociclib, AZD5438",1.20481541031758,0.363512103646635,FALSE
+"H3255","Pearson.est","CHK inhibitor",-0.60702,-1.55,0.0716,1206,0.489,"CHIR.124, SCH.900776, LY2603618, LY2606368, AZD7762",1.14508697769214,0.31069114087638,FALSE
+"H3255","Pearson.est","cyclooxygenase inhibitor",0.19675,0.496,0.979,8,0.979,"phenazone",0.00921730819686218,0.00921730819686218,FALSE
+"H3255","Pearson.est","cytochrome P450 inhibitor",-0.34459,-0.884,0.576,1153,0.932,"itraconazole, cobicistat, eplerenone",0.239577516576788,0.0305840876460186,FALSE
+"H3255","Pearson.est","DNA alkylating agent",-0.3405,-0.879,0.584,1023,0.9,"mitomycin.c, carboplatin, dacarbazine, melphalan, cyclophosphamide, satraplatin",0.233587152887601,0.0457574905606751,FALSE
+"H3255","Pearson.est","DNA inhibitor",0.33756,0.882,0.595,300,0.699,"primaquine, nimorazole, bendamustine, mechlorethamine, pibenzimol, carmustine, oxaliplatin",0.22548303427145,0.155522824254319,FALSE
+"H3255","Pearson.est","DNA methyltransferase inhibitor",0.48536,1.24,0.2,21,0.433,"SGI.1027",0.698970004336019,0.363512103646635,FALSE
+"H3255","Pearson.est","DNA polymerase inhibitor",0.35668,0.931,0.518,152,0.659,"idoxuridine, foscarnet",0.285670240254767,0.18111458540599,FALSE
+"H3255","Pearson.est","DNA synthesis inhibitor",-0.22233,-0.581,0.937,1434,1,"altretamine",0.0282604091122217,0,FALSE
+"H3255","Pearson.est","dopamine receptor antagonist",-0.37702,-0.977,0.463,1154,0.87,"clebopride, raclopride, amisulpride, domperidone, remoxipride, oxiperomide, acetophenazine",0.334419008982047,0.0604807473813815,FALSE
+"H3255","Pearson.est","estrogen receptor agonist",-0.44846,-1.15,0.296,886,0.655,"estradiol.cypionate, levonorgestrel, erteberel, ethinyl.estradiol, PPT, estradiol",0.528708288941061,0.183758700008217,FALSE
+"H3255","Pearson.est","estrogen receptor antagonist",0.46522,1.19,0.259,148,0.452,"tamoxifen, clomifene",0.586700235918748,0.344861565188618,FALSE
+"H3255","Pearson.est","FGFR inhibitor",0.69633,1.74,0.0178,334,0.285,"PD.173074, nintedanib, erdafitinib, lenvatinib, dovitinib, AZD4547, lucitanib, orantinib",1.74957999769111,0.54515513999149,FALSE
+"H3255","Pearson.est","FLT3 inhibitor",0.28839,0.745,0.782,405,0.795,"pacritinib, sunitinib, dovitinib, GTP.14564, TG.02, tandutinib, sorafenib, ENMD.2076",0.106793246940152,0.0996328713435297,FALSE
+"H3255","Pearson.est","glucocorticoid receptor agonist",-0.42644,-1.11,0.315,971,0.686,"piretanide, clobetasol.propionate, fluorometholone, hydrocortisone, dexamethasone.acetate, desonide, fluocinolone.acetonide, fluticasone.propionate, flumethasone.pivalate, triamcinolone, prednisolone.acetate, ciclesonide, prednisolone, fludroxycortide",0.501689446210399,0.163675884293248,FALSE
+"H3255","Pearson.est","glutamate receptor antagonist",0.29607,0.752,0.746,535,0.804,"IEM1754, felbamate, CGP.37849, JNJ.16259685, tiletamine, latrepirdine, CPP, ACDPP",0.127261172527331,0.0947439512515487,FALSE
+"H3255","Pearson.est","glycogen synthase kinase inhibitor",0.41835,1.07,0.359,486,0.514,"CHIR.98014, TWS.119, CHIR.99021, kenpaullone",0.444905551421681,0.289036881004724,FALSE
+"H3255","Pearson.est","growth factor receptor inhibitor",0.59688,1.54,0.0511,322,0.387,"danusertib, AZD3463, GSK1838705A, GSK1904529A",1.29157909986529,0.412289034981089,FALSE
+"H3255","Pearson.est","HCV inhibitor",0.50717,1.28,0.209,327,0.433,"narlaprevir, embelin, daclatasvir",0.679853713888946,0.363512103646635,FALSE
+"H3255","Pearson.est","HDAC inhibitor",-0.4657,-1.23,0.233,1118,0.591,"givinostat, panobinostat, mocetinostat, ACY.1215, SB.939, RG2833, chidamide, nexturastat.a, entinostat, tacedinaline, JNJ.26481585",0.632644078973981,0.228412519118745,FALSE
+"H3255","Pearson.est","histamine receptor antagonist",-0.26334,-0.682,0.824,1207,1,"terfenadine, cyproheptadine, famotidine, lafutidine",0.0840727883028842,0,FALSE
+"H3255","Pearson.est","HMGCR inhibitor",-0.64083,-1.65,0.0459,1030,0.382,"lovastatin, mevastatin, simvastatin, pitavastatin, fluvastatin",1.33818731446274,0.417936637088291,FALSE
+"H3255","Pearson.est","HSP inhibitor",-0.23474,-0.612,0.904,1331,1,"VER.49009, BIIB021",0.0438315695246367,0,FALSE
+"H3255","Pearson.est","JAK inhibitor",0.28782,0.737,0.789,330,0.788,"pacritinib, AZD1480, filgotinib, TG.02, AZ960",0.10292299679058,0.103473782510445,FALSE
+"H3255","Pearson.est","KIT inhibitor",0.58953,1.54,0.075,377,0.387,"pazopanib, imatinib, sunitinib, masitinib, OSI.930, lenvatinib, motesanib, cediranib, tandutinib, dasatinib, sorafenib",1.1249387366083,0.412289034981089,FALSE
+"H3255","Pearson.est","MDM inhibitor",-0.38003,-0.974,0.477,1202,0.83,"RITA, serdemetan",0.321481620959886,0.0809219076239261,FALSE
+"H3255","Pearson.est","MEK inhibitor",-0.55088,-1.44,0.096,1080,0.544,"PD.0325901, PD.318088, AZD8330, refametinib, MEK162, PD.198306, Ro.4987655, TAK.733, BIX.02188, PD.184352, PD.98059",1.01772876696043,0.26440110030182,FALSE
+"H3255","Pearson.est","MET inhibitor",0.56264,1.47,0.086,256,0.395,"AMG458, INC.280, NVP.BVU972, PHA.665752",1.06550154875643,0.40340290437354,FALSE
+"H3255","Pearson.est","microtubule inhibitor",0.33259,0.839,0.661,512,0.714,"vinflunine, secnidazole, triclabendazole, cytochalasin.b, estramustine.phosphate",0.17979854051436,0.146301788223826,FALSE
+"H3255","Pearson.est","mTOR inhibitor",0.4202,1.06,0.391,472,0.513,"WYE.354, WYE.125132, PF.05212384, AZD8055, voxtalisib, ku.0063794, AZD2014, XL388, MLN0128, PKI.179, GSK2126458, palomid.529, OSI.027, temsirolimus",0.407823242604133,0.289882634888184,FALSE
+"H3255","Pearson.est","NFkB pathway inhibitor",-0.30875,-0.803,0.71,1247,1,"parthenolide...., BAY.11.7082, BAY.11.7085",0.148741651280925,0,FALSE
+"H3255","Pearson.est","opioid receptor agonist",0.43955,1.13,0.3,120,0.46,"trimebutine, salvinorin.a",0.522878745280338,0.337242168318426,FALSE
+"H3255","Pearson.est","p38 MAPK inhibitor",-0.49175,-1.27,0.2,1249,0.682,"SB.242235, TAK.715, CMPD.1",0.698970004336019,0.166215625343521,FALSE
+"H3255","Pearson.est","PARP inhibitor",-0.56301,-1.5,0.103,1219,0.499,"AZD2461, AG.14361, niraparib, talazoparib, olaparib",0.987162775294828,0.30189945437661,FALSE
+"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.53746,1.38,0.14,377,0.395,"pazopanib, imatinib, nintedanib, sunitinib, masitinib, crenolanib, lenvatinib, dovitinib, trapidil, motesanib, orantinib, tandutinib, dasatinib, sorafenib",0.853871964321762,0.40340290437354,FALSE
+"H3255","Pearson.est","phosphatase inhibitor",-0.19307,-0.5,0.98,1239,1,"mycophenolate.mofetil, bis.maltolato.oxovanadium.IV.",0.00877392430750515,0,FALSE
+"H3255","Pearson.est","phosphodiesterase inhibitor",-0.50705,-1.34,0.147,1094,0.604,"YM.976, trequinsin, avanafil, papaverine, zardaverine, GSK256066",0.832682665251824,0.218963061378868,FALSE
+"H3255","Pearson.est","PI3K inhibitor",0.33071,0.864,0.618,534,0.694,"CH5132799, PF.05212384, voxtalisib, TG.100713, BGT226, PKI.179, PI.828, GSK2126458, taselisib, buparlisib, CUDC.907, PIK.75, PF.04691502",0.209011524911184,0.158640529545145,FALSE
+"H3255","Pearson.est","PLK inhibitor",0.53398,1.37,0.151,121,0.368,"NMS.1286937, volasertib",0.821023052706831,0.434152181326482,FALSE
+"H3255","Pearson.est","potassium channel blocker",-0.34201,-0.906,0.553,1221,0.928,"ibutilide, meglitinide",0.257274868695302,0.0324520237811379,FALSE
+"H3255","Pearson.est","PPAR receptor agonist",-0.50994,-1.35,0.161,1392,0.656,"clofibrate, pterostilbene",0.79317412396815,0.18309616062434,FALSE
+"H3255","Pearson.est","progesterone receptor agonist",-0.65274,-1.72,0.0381,1199,1,"norgestrel, tanaproget, norethindrone, dienogest, norethindrone.acetate",1.41907502432438,0,FALSE
+"H3255","Pearson.est","proteasome inhibitor",0.59705,1.57,0.0553,207,0.433,"oprozomib, bortezomib, MG.132",1.2572748686953,0.363512103646635,FALSE
+"H3255","Pearson.est","protein synthesis inhibitor",-0.21236,-0.544,0.952,1316,1,"azomycin..2.nitroimidazole., emetine",0.0213630516155257,0,FALSE
+"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.75495,1.99,0,44,0.0701,"BMS.599626, CP.724714, mubritinib",Inf,1.15428198203334,TRUE
+"H3255","Pearson.est","RAF inhibitor",0.53254,1.37,0.145,416,0.368,"dabrafenib, SB.590885, GDC.0879, LGX818, sorafenib, AZ.628",0.838631997765025,0.434152181326482,FALSE
+"H3255","Pearson.est","RET tyrosine kinase inhibitor",0.57702,1.47,0.108,579,0.395,"sunitinib, apatinib, sorafenib, regorafenib, cabozantinib",0.96657624451305,0.40340290437354,FALSE
+"H3255","Pearson.est","retinoid receptor agonist",-0.48459,-1.26,0.207,1157,0.636,"AM.580, tamibarotene, LE.135, adapalene",0.684029654543082,0.196542884351586,FALSE
+"H3255","Pearson.est","ribonucleotide reductase inhibitor",0.33844,0.866,0.607,506,0.708,"fludarabine.phosphate, cytarabine, pentostatin, LY2334737, gemcitabine",0.216811308924742,0.149966742310231,FALSE
+"H3255","Pearson.est","serotonin receptor agonist",0.74022,1.92,0.00992,46,0.0954,"aripiprazole, ipsapirone",2.00348832784582,1.0204516252959,TRUE
+"H3255","Pearson.est","serotonin receptor antagonist",0.43993,1.14,0.306,1,0.462,"aripiprazole",0.51427857351842,0.335358024443874,FALSE
+"H3255","Pearson.est","sodium channel blocker",-0.27343,-0.704,0.831,1225,1,"A.803467, mexiletine, benzethonium",0.080398976215889,0,FALSE
+"H3255","Pearson.est","src inhibitor",0.56068,1.44,0.0975,241,0.38,"TG.100572, saracatinib, masitinib, PP.1, ZM.306416",1.01099538430146,0.42021640338319,FALSE
+"H3255","Pearson.est","sterol demethylase inhibitor",-0.65219,-1.68,0.0304,1424,0.653,"terconazole, lanoconazole",1.51712641639125,0.185086818724926,FALSE
+"H3255","Pearson.est","TGF beta receptor inhibitor",0.78709,2.05,0.00192,222,0.0826,"LY2109761, SB.431542, repsox, adaprev, D.4476",2.71669877129645,1.08301995267962,TRUE
+"H3255","Pearson.est","thymidylate synthase inhibitor",0.4838,1.23,0.224,459,0.413,"capecitabine, raltitrexed, carmofur, trifluridine",0.649751981665837,0.384049948343599,FALSE
+"H3255","Pearson.est","topoisomerase inhibitor",-0.46282,-1.18,0.242,1113,0.642,"camptothecin, rubitecan, amsacrine, teniposide, amonafide, voreloxin, mitoxantrone, etoposide, epirubicin, genz.644282, doxorubicin, TAS.103, beta.lapachone",0.616184634019569,0.192464971931147,FALSE
+"H3255","Pearson.est","tubulin polymerization inhibitor",-0.16097,-0.419,0.998,1182,0.996,"CYT.997, verubulin, dolastatin.10, podophyllotoxin, BNC105",0.000869458712628891,0.00174066157630127,FALSE
+"H3255","Pearson.est","tyrosine kinase inhibitor",0.49909,1.27,0.197,377,0.41,"BMS.599626, CP.724714, mubritinib, sunitinib, apatinib, tivantinib, GTP.14564, tyrphostin.A9, dasatinib, sorafenib",0.705533773838407,0.387216143280265,FALSE
+"H3255","Pearson.est","VEGFR inhibitor",0.51788,1.35,0.147,334,0.377,"foretinib, PD.173074, pazopanib, TG.100572, AEE788, nintedanib, BMS.690514, golvatinib, sunitinib, OSI.930, lenvatinib, dovitinib, XL.647, tivozanib, ZM.306416, lucitanib, motesanib, cediranib, orantinib",0.832682665251824,0.423658649794207,FALSE
+"H3255","Pearson.est","vitamin D receptor agonist",0.54682,1.44,0.105,413,0.38,"tacalcitol, alfacalcidol, maxacalcitol, doxercalciferol",0.978810700930062,0.42021640338319,FALSE
+"H1648","Pearson.est","EGFR inhibitor",0.20896,0.538,0.944,305,1,"AEE788, CUDC.101, GW.583340, tucatinib, BMS.690514, lapatinib, XL.647, AZD8931, AST.1306, osimertinib",0.025028005701931,0,FALSE
+"H1648","Pearson.est","Abl kinase inhibitor",-0.37303,-0.958,0.495,1225,0.852,"ponatinib, tozasertib, nilotinib, KW.2449",0.305394801066431,0.0695604052332999,FALSE
+"H1648","Pearson.est","acetylcholine receptor agonist",-0.56603,-1.46,0.0956,1145,0.443,"tremorine, nicotine",1.0195421077239,0.35359627377693,FALSE
+"H1648","Pearson.est","acetylcholine receptor antagonist",-0.31283,-0.79,0.709,1059,0.965,"methscopolamine, iododexetimide, dicycloverine",0.149353764816933,0.0154726866562074,FALSE
+"H1648","Pearson.est","adenosine receptor antagonist",0.43305,1.11,0.33,214,0.715,"PSB.1115, sulmazole, CGS.15943",0.481486060122112,0.145693958198919,FALSE
+"H1648","Pearson.est","adrenergic receptor agonist",-0.38621,-0.993,0.421,1148,0.843,"terbutaline, metaraminol, isoxsuprine, norepinephrine, epinephrine, isoetharine",0.375717904164332,0.0741724253752577,FALSE
+"H1648","Pearson.est","adrenergic receptor antagonist",0.50878,1.31,0.177,291,0.559,"practolol, RS.17053, propranolol, oxprenolol, prazosin, atenolol...., dihydroergocristine",0.752026733638193,0.252588192113577,FALSE
+"H1648","Pearson.est","AKT inhibitor",0.19632,0.498,0.977,91,1,"palomid.529",0.0101054362812269,0,FALSE
+"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.42487,1.13,0.301,423,0.766,"SB.505124, AZD3463, DMH1, GW.788388, AP26113",0.521433504406157,0.115771230367396,FALSE
+"H1648","Pearson.est","androgen receptor antagonist",0.55089,1.43,0.116,7,0.557,"bicalutamide",0.935542010773082,0.254144804826271,FALSE
+"H1648","Pearson.est","antioxidant",-0.28928,-0.744,0.772,1279,0.933,"trolox",0.112382699664264,0.0301183562535,FALSE
+"H1648","Pearson.est","AP inhibitor",-0.3474,-0.87,0.609,1409,0.904,"idronoxil",0.215382707367125,0.0438315695246367,FALSE
+"H1648","Pearson.est","ATPase inhibitor",-0.43494,-1.09,0.346,1378,0.784,"digitoxigenin, rabeprazole, digitoxin",0.460923901207223,0.105683937315562,FALSE
+"H1648","Pearson.est","Aurora kinase inhibitor",-0.63369,-1.59,0.0505,1015,0.389,"barasertib.HQPA, alisertib, CYC116, MK.5108, barasertib, PHA.680632, CCT137690, PF.03814735, tozasertib, hesperadin, SNS.314, TAK.901, MLN.8054, AT.9283, AMG900, GSK1070916, MK.8745, KW.2449",1.29670862188134,0.410050398674292,FALSE
+"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.46618,1.19,0.254,73,0.69,"tilmicosin, josamycin",0.595166283380062,0.161150909262745,FALSE
+"H1648","Pearson.est","bacterial DNA gyrase inhibitor",-0.3093,-0.776,0.736,1437,0.933,"sarafloxacin",0.133122185662501,0.0301183562535,FALSE
+"H1648","Pearson.est","BCL inhibitor",-0.70378,-1.77,0.0159,1233,0.368,"gossypol, HA14.1, venetoclax, TW.37",1.79860287567955,0.434152181326482,FALSE
+"H1648","Pearson.est","Bcr.Abl kinase inhibitor",-0.34722,-0.904,0.533,1225,0.934,"ponatinib, tozasertib, nilotinib",0.273272790973428,0.0296531237699066,FALSE
+"H1648","Pearson.est","benzodiazepine receptor agonist",0.38669,1.02,0.413,288,0.78,"eprinomectin, ZK.93423, gamma.aminobutyric.acid, indiplon, CL.218872",0.384049948343599,0.10790539730952,FALSE
+"H1648","Pearson.est","bromodomain inhibitor",-0.72968,-1.81,0.00865,1154,0.569,"JQ1...., I.BET.762, PFI.1, bromosporine, I.BET151",2.06298389253519,0.244887733604929,FALSE
+"H1648","Pearson.est","calcium channel blocker",0.42558,1.11,0.336,420,0.715,"fendiline, carboxyamidotriazole, penfluridol, SR.33805, cinnarazine, SKF.96365",0.473660722610156,0.145693958198919,FALSE
+"H1648","Pearson.est","CC chemokine receptor antagonist",0.5398,1.42,0.111,577,0.515,"ZK811752, MK.0812, UNBS.5162, SB.225002, RS.504393, PF.04136309",0.954677021213343,0.288192770958809,FALSE
+"H1648","Pearson.est","CDK inhibitor",-0.55919,-1.42,0.11,1198,0.435,"P276.00, indirubin, TG.02, JNJ.7706621, AZD5438, palbociclib, ribociclib, BMS.265246, aminopurvalanol.a, abemaciclib, PHA.848125",0.958607314841775,0.361510743045363,FALSE
+"H1648","Pearson.est","CHK inhibitor",-0.69525,-1.76,0.0226,1273,0.266,"AZD7762, LY2603618, LY2606368, SCH.900776",1.6458915608526,0.575118363368933,FALSE
+"H1648","Pearson.est","cyclooxygenase inhibitor",-0.30654,-0.781,0.745,904,0.952,"naproxen, suxibuzone, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, tepoxalin, FK.3311, ketoprofen, AM.404, aspirin, amfenac, curcumin",0.127843727251707,0.0213630516155257,FALSE
+"H1648","Pearson.est","cytochrome P450 inhibitor",0.32053,0.845,0.626,203,0.825,"itraconazole, PF.4981517",0.20342566678957,0.0835460514500749,FALSE
+"H1648","Pearson.est","DNA alkylating agent",-0.3442,-0.881,0.593,1219,0.946,"mitomycin.c, melphalan, satraplatin, cyclophosphamide",0.226945306635737,0.0241088635982073,FALSE
+"H1648","Pearson.est","DNA inhibitor",0.39801,1.04,0.386,319,0.779,"bendamustine, chlorambucil, carmustine, tirapazamine, oxaliplatin, metronidazole, sangivamycin",0.413412695328245,0.108462542327436,FALSE
+"H1648","Pearson.est","DNA methyltransferase inhibitor",0.45478,1.2,0.234,103,0.722,"RG108, SGI.1027",0.630784142589857,0.141462802430361,FALSE
+"H1648","Pearson.est","DNA polymerase inhibitor",-0.3249,-0.808,0.688,1160,0.962,"menadione, famciclovir",0.162411561764489,0.0168249279621871,FALSE
+"H1648","Pearson.est","DNA synthesis inhibitor",-0.23752,-0.607,0.917,1219,0.982,"mitomycin.c, cyclocytidine, altretamine",0.0376306643299789,0.00788851221305034,FALSE
+"H1648","Pearson.est","dopamine receptor antagonist",-0.27558,-0.708,0.826,1077,0.961,"ziprasidone, oxiperomide, UH.232...., remoxipride, raclopride, amisulpride",0.0830199526796178,0.0172766123314547,FALSE
+"H1648","Pearson.est","estrogen receptor agonist",0.37492,0.98,0.469,425,0.723,"equol, estrone, estradiol.cypionate, levonorgestrel",0.328827157284917,0.140861702705469,FALSE
+"H1648","Pearson.est","estrogen receptor antagonist",0.63023,1.67,0.0323,322,0.523,"toremifene, raloxifene, danazol, tamoxifen",1.4907974776689,0.281498311132726,FALSE
+"H1648","Pearson.est","FGFR inhibitor",0.62746,1.66,0.0308,442,0.413,"erdafitinib, PD.173074, lucitanib, MK.2461, nintedanib, lenvatinib, regorafenib, AZD4547",1.51144928349956,0.384049948343599,FALSE
+"H1648","Pearson.est","FLT3 inhibitor",-0.53066,-1.36,0.146,1071,0.414,"quizartinib, pacritinib, sunitinib, gilteritinib, TG.02, ponatinib, lestaurtinib, tozasertib, KW.2449",0.835647144215563,0.382999658879101,FALSE
+"H1648","Pearson.est","glucocorticoid receptor agonist",-0.59755,-1.51,0.114,1337,0.441,"fludroxycortide, flumethasone.pivalate, triamcinolone, dexamethasone.acetate, fluticasone.propionate, desonide, fluocinolone.acetonide, prednisolone",0.943095148663527,0.355561410532161,FALSE
+"H1648","Pearson.est","glutamate receptor antagonist",0.37626,0.973,0.469,199,0.706,"MTPG, CGP.37849, LY456236, felbamate",0.328827157284917,0.151195298948196,FALSE
+"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.28824,0.754,0.755,160,0.916,"CHIR.98014, CHIR.99021",0.122053048370812,0.0381045263321496,FALSE
+"H1648","Pearson.est","growth factor receptor inhibitor",-0.48855,-1.23,0.226,1276,0.547,"lestaurtinib, PHA.848125",0.645891560852599,0.262012673666569,FALSE
+"H1648","Pearson.est","HCV inhibitor",0.38002,0.991,0.442,116,0.734,"narlaprevir, embelin",0.354577730650908,0.134303940083929,FALSE
+"H1648","Pearson.est","HDAC inhibitor",-0.48803,-1.24,0.216,1052,0.558,"resminostat, PCI.24781, AR.42, vorinostat, panobinostat, belinostat, dacinostat, R306465, givinostat, nexturastat.a, romidepsin, JNJ.26481585, trichostatin.a, RG2833",0.665546248849069,0.253365801062421,FALSE
+"H1648","Pearson.est","histamine receptor antagonist",0.38084,0.993,0.416,204,0.8,"cimetidine, epinastine, nizatidine, tecastemizole, ranitidine",0.380906669373257,0.0969100130080564,FALSE
+"H1648","Pearson.est","HMGCR inhibitor",0.29142,0.746,0.741,373,0.9,"simvastatin, mevastatin, atorvastatin",0.130181792020672,0.0457574905606751,FALSE
+"H1648","Pearson.est","HSP inhibitor",-0.34,-0.876,0.589,1088,0.923,"VER.49009, XL888, BIIB021, NVP.AUY922, ganetespib",0.229884705212898,0.0347982989740879,FALSE
+"H1648","Pearson.est","JAK inhibitor",-0.58132,-1.48,0.102,1205,0.45,"PRT062070, TG.02, lestaurtinib, AZ960, tozasertib, AT.9283, TG.101209, CEP.33779",0.991399828238082,0.346787486224656,FALSE
+"H1648","Pearson.est","KIT inhibitor",-0.20913,-0.518,0.97,1084,0.971,"imatinib, sunitinib, telatinib, masitinib, vatalanib",0.0132282657337552,0.0127807700919951,FALSE
+"H1648","Pearson.est","MDM inhibitor",-0.54415,-1.41,0.118,1344,0.418,"nutlin.3, serdemetan",0.928117992693875,0.378823718224965,FALSE
+"H1648","Pearson.est","MEK inhibitor",-0.54587,-1.37,0.15,1224,0.424,"cobimetinib, AS.703026, AZD8330, refametinib, PD.0325901, trametinib, TAK.733, MEK162, nobiletin, BIX.02188, PD.184352",0.823908740944319,0.372634143407267,FALSE
+"H1648","Pearson.est","MET inhibitor",0.38753,0.992,0.448,22,0.765,"AMG458",0.348721986001856,0.116338564846382,FALSE
+"H1648","Pearson.est","microtubule inhibitor",-0.39899,-0.98,0.473,1049,0.837,"colchicine, vinblastine, D.64131, cytochalasin.b",0.325138859262188,0.07727454200674,FALSE
+"H1648","Pearson.est","mTOR inhibitor",0.17116,0.448,0.998,462,1,"palomid.529, PF.05212384, voxtalisib, LY303511, WYE.354, deforolimus, GSK2126458, temsirolimus, sirolimus, everolimus, PKI.179, WYE.125132",0.000869458712628891,0,FALSE
+"H1648","Pearson.est","NFkB pathway inhibitor",-0.54557,-1.38,0.144,1116,0.438,"BAY.11.7085, IKK.2.inhibitor.V, betulinic.acid, EVP4593, curcumin",0.84163750790475,0.3585258894959,FALSE
+"H1648","Pearson.est","opioid receptor agonist",0.42344,1.1,0.346,12,0.695,"spiradoline",0.460923901207223,0.158015195409886,FALSE
+"H1648","Pearson.est","p38 MAPK inhibitor",-0.31733,-0.815,0.684,803,0.98,"SB.239063, TAK.715, CMPD.1, skepinone.l",0.164943898279884,0.00877392430750515,FALSE
+"H1648","Pearson.est","PARP inhibitor",-0.638,-1.64,0.0506,1127,0.349,"AZD2461, endo.IWR.1, olaparib, niraparib, talazoparib",1.2958494831602,0.45717457304082,FALSE
+"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.26421,-0.673,0.848,1084,0.958,"imatinib, SU014813, sunitinib, telatinib, masitinib, ponatinib, axitinib, vatalanib",0.0716041477432862,0.0186344909214556,FALSE
+"H1648","Pearson.est","phosphatase inhibitor",-0.30505,-0.775,0.73,1026,0.909,"bis.maltolato.oxovanadium.IV., alexidine, menadione, CID.5458317, mycophenolate.mofetil",0.136677139879544,0.0414361167780325,FALSE
+"H1648","Pearson.est","phosphodiesterase inhibitor",-0.26324,-0.665,0.861,1326,0.944,"avanafil, GSK256066",0.0649968485463452,0.025028005701931,FALSE
+"H1648","Pearson.est","PI3K inhibitor",-0.20776,-0.53,0.963,1080,0.989,"ZSTK.474, idelalisib, PI.103, SB.2343, NVP.BEZ235, TG100.115, YM.201636, pilaralisib",0.0163737128754655,0.0048037084028206,FALSE
+"H1648","Pearson.est","PLK inhibitor",-0.41655,-1.06,0.397,1029,0.774,"HMN.214, rigosertib, GW.843682X",0.401209493236885,0.111259039317107,FALSE
+"H1648","Pearson.est","potassium channel blocker",0.58647,1.51,0.0811,264,0.468,"mepivacaine, dofetilide, ML133, oleoylethanolamide",1.09097914578884,0.329754146925876,FALSE
+"H1648","Pearson.est","PPAR receptor agonist",0.5323,1.4,0.141,301,0.497,"fenofibrate, oleoylethanolamide, GW.501516, pterostilbene",0.85078088734462,0.303643611266668,FALSE
+"H1648","Pearson.est","progesterone receptor agonist",-0.66028,-1.66,0.0354,1114,0.392,"norethindrone.acetate, melengestrol.acetate, tanaproget, nomegestrol.acetate, norethindrone, dienogest, norgestrel",1.45099673797421,0.406713932979543,FALSE
+"H1648","Pearson.est","proteasome inhibitor",-0.55988,-1.42,0.104,1147,0.435,"ixazomib, carfilzomib, oprozomib, ixazomib.citrate",0.98296666070122,0.361510743045363,FALSE
+"H1648","Pearson.est","protein synthesis inhibitor",0.24288,0.636,0.888,174,1,"clofoctol, brefeldin.a, puromycin",0.051587034221399,0,FALSE
+"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.42506,-1.07,0.338,951,0.789,"PP.121, rheochrysidin, AV.412, NVP.TAE226",0.471083299722345,0.10292299679058,FALSE
+"H1648","Pearson.est","RAF inhibitor",0.23693,0.619,0.895,504,1,"LGX818, dabrafenib, GDC.0879, regorafenib, AZ.628, sorafenib",0.048176964684088,0,FALSE
+"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.33339,0.872,0.597,504,0.835,"cabozantinib, regorafenib, apatinib, sorafenib",0.224025668870631,0.0783135245163979,FALSE
+"H1648","Pearson.est","retinoid receptor agonist",0.67134,1.78,0.0252,237,0.83,"fenretinide, bexarotene, tamibarotene, adapalene, AM.580",1.59859945921846,0.0809219076239261,FALSE
+"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.51749,1.33,0.178,366,0.568,"fludarabine.phosphate, cytarabine, triapine, gemcitabine, cladribine",0.749579997691106,0.245651664288981,FALSE
+"H1648","Pearson.est","serotonin receptor agonist",-0.60396,-1.52,0.0755,1282,0.478,"pardoprunox, aripiprazole",1.12205304837081,0.320572103387881,FALSE
+"H1648","Pearson.est","serotonin receptor antagonist",-0.51447,-1.3,0.193,1443,0.482,"aripiprazole, tropisetron",0.714442690992226,0.31695296176115,FALSE
+"H1648","Pearson.est","sodium channel blocker",0.33409,0.86,0.626,218,0.827,"mepivacaine, cibenzoline, oxcarbazepine, triamterene",0.20342566678957,0.0824944904474534,FALSE
+"H1648","Pearson.est","src inhibitor",0.3573,0.922,0.534,208,0.773,"TG.100572, ZM.306416, dasatinib",0.272458742971444,0.111820506081675,FALSE
+"H1648","Pearson.est","sterol demethylase inhibitor",-0.27679,-0.703,0.822,1178,0.944,"sulconazole, ketoconazole",0.0851281824599496,0.025028005701931,FALSE
+"H1648","Pearson.est","TGF beta receptor inhibitor",0.67211,1.76,0.0246,68,0.471,"LY2109761, repsox",1.60906489289662,0.326979092871104,FALSE
+"H1648","Pearson.est","thymidylate synthase inhibitor",0.59805,1.57,0.0644,316,0.422,"doxifluridine, raltitrexed, ftorafur",1.19111413264019,0.374687549038326,FALSE
+"H1648","Pearson.est","topoisomerase inhibitor",-0.22356,-0.557,0.942,882,0.996,"fleroxacin, irinotecan, teniposide, doxorubicin, daunorubicin, valrubicin, amsacrine, genz.644282, beta.lapachone, amonafide, voreloxin, TAS.103",0.0259490972071227,0.00174066157630127,FALSE
+"H1648","Pearson.est","tubulin polymerization inhibitor",-0.39565,-1.01,0.422,1004,0.843,"combretastatin.A.4, nocodazole, albendazole, ABT.751, flubendazole, vindesine, BNC105, vinblastine, KX2.391, verubulin, fosbretabulin, epothilone.d",0.374687549038326,0.0741724253752577,FALSE
+"H1648","Pearson.est","tyrosine kinase inhibitor",0.1597,0.417,0.998,208,0.996,"cabozantinib, GTP.14564, bafetinib, dasatinib",0.000869458712628891,0.00174066157630127,FALSE
+"H1648","Pearson.est","VEGFR inhibitor",0.32479,0.844,0.648,388,0.8,"TG.100572, ZM.306416, AEE788, cabozantinib, cediranib, pazopanib, BMS.690514, PD.173074, XL.647, motesanib, lucitanib, MK.2461, nintedanib, lenvatinib, regorafenib, MGCD.265",0.188424994129407,0.0969100130080564,FALSE
+"H1648","Pearson.est","vitamin D receptor agonist",0.62527,1.65,0.0458,410,0.345,"maxacalcitol, tacalcitol, doxercalciferol, ercalcitriol, paricalcitol",1.33913452199613,0.462180904926726,FALSE
+"H1975","Pearson.est","EGFR inhibitor",-0.2474,-0.606,0.916,1080,0.951,"brigatinib, WZ.4002, OSI.420, pelitinib, tyrphostin.AG.1478, BIBX.1382, CGP.52411, vandetanib, icotinib, CNX.2006, WZ8040, rociletinib",0.0381045263321496,0.0218194830625861,FALSE
+"H1975","Pearson.est","Abl kinase inhibitor",-0.5492,-1.33,0.152,1073,0.515,"imatinib, GZD824, flumatinib, ponatinib, bosutinib, KW.2449, tozasertib",0.818156412055227,0.288192770958809,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",-0.56553,-1.4,0.0828,838,0.552,"pilocarpine, oxiracetam, xanomeline, tremorine, nicotine",1.08196966321512,0.258060922270801,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",0.32454,0.938,0.512,103,0.691,"hyoscyamine, darifenacin",0.290730039024169,0.160521952625802,FALSE
+"H1975","Pearson.est","adenosine receptor antagonist",0.58481,1.7,0.0469,170,0.255,"PSB.1115, SCH.58261, CGS.15943, MRS.1220",1.32882715728492,0.593459819566045,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",0.2253,0.663,0.872,68,0.871,"methyldopa, metaraminol",0.0594835150674328,0.0599818449923368,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.23992,0.701,0.841,111,0.875,"practolol, prazosin, atenolol....",0.0752040042020878,0.0579919469776868,FALSE
+"H1975","Pearson.est","AKT inhibitor",-0.40749,-0.981,0.498,907,0.816,"triciribine, AZD5363, uprosertib, CCT128930, AT7867",0.302770657240282,0.0883098412461389,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41623,-1.02,0.446,1080,0.797,"brigatinib, lorlatinib, alectinib, AZD3463, AP26113",0.350665141287858,0.0985416786038876,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",-0.37122,-0.918,0.574,853,0.885,"flutamide, nilutamide",0.241088107602027,0.0530567293021746,FALSE
+"H1975","Pearson.est","antioxidant",-0.54753,-1.36,0.124,952,0.537,"trolox, chlorogenic.acid, benfotiamine, mesna",0.906578314837765,0.270025714300444,FALSE
+"H1975","Pearson.est","AP inhibitor",0.5033,1.54,0.0563,292,0.336,"tanshinone.i, birinapant, GDC.0152, embelin",1.24949160514865,0.473660722610156,FALSE
+"H1975","Pearson.est","ATPase inhibitor",-0.23433,-0.566,0.948,1433,0.963,"digitoxin",0.0231916626619338,0.0163737128754655,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",-0.68329,-1.66,0.0153,1142,1,"MK.5108, MK.8745, MLN.8054, ZM.447439, TAK.901, CCT137690, PF.03814735, CCT129202, GSK1070916, alisertib, SNS.314, AMG900, KW.2449, hesperadin, tozasertib, AT.9283, CYC116",1.8153085691824,0,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44247,-1.08,0.386,1034,0.776,"radezolid, tilmicosin, azalomycin.b, valnemulin",0.413412695328245,0.110138278741812,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.30146,-0.741,0.78,1233,0.974,"finafloxacin, novobiocin",0.10790539730952,0.0114410431213845,FALSE
+"H1975","Pearson.est","BCL inhibitor",-0.60548,-1.51,0.0623,1254,0.531,"HA14.1, gossypol, TW.37",1.20551195334083,0.274905478918531,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.55372,-1.37,0.125,1073,0.549,"imatinib, GZD824, flumatinib, ponatinib, bosutinib, tozasertib",0.903089986991944,0.260427655549908,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.48672,1.42,0.125,168,0.407,"gamma.aminobutyric.acid, eprinomectin, indiplon, CL.218872, ZK.93423, temazepam",0.903089986991944,0.39040559077478,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",-0.48039,-1.16,0.289,937,0.686,"OTX015, JQ1...., PFI.1, bromosporine",0.539102157243452,0.163675884293248,FALSE
+"H1975","Pearson.est","calcium channel blocker",0.47565,1.4,0.124,34,0.361,"SKF.96365, fendiline, efonidipine.monoethanolate",0.906578314837765,0.442492798094342,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",0.37281,1.14,0.264,1,0.452,"ZK811752",0.578396073130169,0.344861565188618,FALSE
+"H1975","Pearson.est","CDK inhibitor",-0.35156,-0.868,0.633,1197,0.939,"indirubin, palbociclib, PHA.848125, abemaciclib, BMS.265246, aminopurvalanol.a",0.198596289982645,0.0273344077338891,FALSE
+"H1975","Pearson.est","CHK inhibitor",-0.58438,-1.44,0.0824,979,0.603,"SCH.900776, SB.218078, AZD7762, LY2606368, LY2603618",1.08407278830288,0.219682687859849,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.49392,-1.21,0.245,1211,0.593,"aspirin, acetylsalicylsalicylic.acid, ketoprofen, FR.122047, piroxicam, tepoxalin",0.610833915635468,0.226945306635737,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.34405,-0.857,0.634,1191,0.94,"cobicistat, eplerenone",0.197910742118267,0.0268721464003014,FALSE
+"H1975","Pearson.est","DNA alkylating agent",-0.40888,-1,0.478,962,0.816,"carboplatin, melphalan, satraplatin, streptozotocin, TH.302, cyclophosphamide",0.320572103387881,0.0883098412461389,FALSE
+"H1975","Pearson.est","DNA inhibitor",-0.21391,-0.523,0.973,962,0.969,"carboplatin, melphalan, teroxirone, chlorambucil, valrubicin",0.0118871597316481,0.0136762229492347,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",-0.34393,-0.843,0.678,1220,0.945,"RG108, decitabine",0.168770306132937,0.0245681914907371,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",-0.41156,-0.99,0.477,955,0.818,"famciclovir, idoxuridine, cephalomannine, menadione",0.321481620959886,0.087246696328677,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",-0.32434,-0.793,0.739,1089,0.933,"cyclocytidine, artesunate, anisomycin, CB.10.277",0.131355561605174,0.0301183562535,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",-0.3336,-0.806,0.726,1281,0.93,"raclopride, oxiperomide, thioproperazine, UH.232....",0.139063379299906,0.0315170514460649,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.50733,-1.23,0.214,1118,0.571,"ethinyl.estradiol, estradiol.cypionate, estrone, PPT",0.669586226650809,0.243363891754152,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",0.43481,1.28,0.212,821,0.32,"toremifene, tamoxifen, danazol, raloxifene, clomifene, fulvestrant",0.673664139071249,0.494850021680094,FALSE
+"H1975","Pearson.est","FGFR inhibitor",-0.35552,-0.868,0.632,1339,0.939,"nintedanib, AZD4547",0.199282921717615,0.0273344077338891,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",-0.52649,-1.28,0.198,1293,0.529,"ponatinib, lestaurtinib, midostaurin, quizartinib, KW.2449, tozasertib",0.703334809738469,0.276544327964814,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",-0.42474,-1.05,0.399,765,0.773,"prednisolone.acetate, desonide, prednisolone.hemisuccinate, flumethasone.pivalate, fluorometholone, rimexolone, dexamethasone.acetate, beclomethasone.dipropionate, halcinonide, clobetasol.propionate, triamcinolone, ciclesonide, methylprednisolone, fluticasone.propionate, fluocinolone.acetonide, prednisolone",0.399027104313252,0.111820506081675,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",-0.24498,-0.61,0.909,1424,0.963,"SIB.1757",0.0414361167780325,0.0163737128754655,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.30051,-0.734,0.792,1117,0.966,"TWS.119, indirubin, tideglusib",0.101274818410506,0.0150228735845067,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",-0.61302,-1.52,0.0526,1057,0.695,"danusertib, GSK1838705A, PHA.848125, AZD3463, lestaurtinib",1.27901425584626,0.158015195409886,FALSE
+"H1975","Pearson.est","HCV inhibitor",-0.25447,-0.63,0.901,1258,0.962,"narlaprevir",0.045275209020937,0.0168249279621871,FALSE
+"H1975","Pearson.est","HDAC inhibitor",-0.5564,-1.37,0.12,980,0.549,"chidamide, SB.939, panobinostat, trichostatin.a, M.344, JNJ.26481585, entinostat, mocetinostat, vorinostat, dacinostat, belinostat, AR.42, givinostat, RG2833, resminostat, ACY.1215",0.920818753952375,0.260427655549908,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",-0.30853,-0.745,0.777,739,0.988,"famotidine, cyproheptadine, ebastine, levocetirizine, nizatidine, pheniramine, lafutidine, ICI.162846, terfenadine, BF2.649, tiotidine",0.109578981199086,0.00524305541237188,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.6061,-1.51,0.0491,874,0.531,"atorvastatin, lovastatin, mevastatin, simvastatin, fluvastatin, pitavastatin",1.30891850787703,0.274905478918531,FALSE
+"H1975","Pearson.est","HSP inhibitor",-0.63562,-1.58,0.0353,1041,0.78,"tanespimycin, SNX.5422, SNX.2112, XL888, NVP.AUY922, PU.H71, BIIB021, VER.49009, ganetespib",1.45222529461218,0.10790539730952,FALSE
+"H1975","Pearson.est","JAK inhibitor",-0.52023,-1.28,0.168,1282,0.529,"filgotinib, lestaurtinib, AZ960, tozasertib, PRT062070, AT.9283",0.774690718274137,0.276544327964814,FALSE
+"H1975","Pearson.est","KIT inhibitor",-0.37582,-0.93,0.548,1058,0.903,"telatinib, imatinib, masitinib, midostaurin, KI.8751, vatalanib",0.261219441515631,0.0443122496864942,FALSE
+"H1975","Pearson.est","MDM inhibitor",-0.59293,-1.47,0.0764,855,0.579,"nutlin.3, AMG.232, serdemetan, idasanutlin, RITA, CGM097",1.11690664142431,0.237321436272564,FALSE
+"H1975","Pearson.est","MEK inhibitor",-0.42763,-1.04,0.419,778,0.775,"PD.318088, AS.703026, trametinib, PD.198306, selumetinib, MEK162, PD.0325901, Ro.4987655, AZD8330, PD.98059, refametinib, TAK.733, PD.184352, nobiletin",0.377785977033705,0.11069829749369,FALSE
+"H1975","Pearson.est","MET inhibitor",-0.3791,-0.926,0.569,1190,0.89,"PF.04217903",0.244887733604929,0.0506099933550872,FALSE
+"H1975","Pearson.est","microtubule inhibitor",-0.46229,-1.12,0.349,1046,0.733,"podophyllotoxin, cytochalasin.b, cabazitaxel, vinblastine, D.64131",0.45717457304082,0.134896025358872,FALSE
+"H1975","Pearson.est","mTOR inhibitor",0.45023,1.29,0.165,263,0.388,"voxtalisib, AZD8055, temsirolimus, deforolimus, PF.05212384, OSI.027, sirolimus, WYE.125132, PKI.179, WYE.354, XL388, PP242",0.782516055786094,0.411168274405793,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",-0.3325,-0.821,0.698,675,0.944,"bortezomib, IKK.2.inhibitor.V, EVP4593, Ro.106.9920, curcumin, BAY.11.7085, BAY.11.7082, betulinic.acid",0.156144577376839,0.025028005701931,FALSE
+"H1975","Pearson.est","opioid receptor agonist",0.33287,0.992,0.427,968,0.646,"spiradoline, cebranopadol, ADL5859, BW.180C, trimebutine, salvinorin.a",0.369572124974976,0.189767482004916,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",-0.63305,-1.54,0.0451,1297,0.769,"CMPD.1, VX.702",1.34582345812204,0.114073660198569,FALSE
+"H1975","Pearson.est","PARP inhibitor",-0.47453,-1.15,0.299,1327,0.686,"talazoparib, niraparib",0.52432881167557,0.163675884293248,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52572,-1.28,0.182,1058,0.529,"telatinib, imatinib, trapidil, SU014813, masitinib, ponatinib, nintedanib, KI.8751, CP.673451, crenolanib, vatalanib, axitinib",0.739928612014925,0.276544327964814,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",-0.55401,-1.34,0.125,1325,0.519,"bis.maltolato.oxovanadium.IV., menadione, CID.5458317",0.903089986991944,0.284832642151542,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",-0.28468,-0.686,0.839,1426,0.99,"GSK256066",0.0762380391712997,0.00436480540245009,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.24161,0.714,0.808,234,0.912,"BGT226, voxtalisib, PF.05212384, AZD6482, CH5132799, idelalisib, PI.828, PKI.179, TG100.115",0.0925886392254138,0.0400051616715838,FALSE
+"H1975","Pearson.est","PLK inhibitor",-0.67066,-1.65,0.014,1146,0.704,"volasertib, HMN.214, BI.2536, GSK461364, rigosertib",1.85387196432176,0.152427340857888,FALSE
+"H1975","Pearson.est","potassium channel blocker",0.43591,1.28,0.188,65,0.32,"dofetilide, ML133",0.72584215073632,0.494850021680094,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",0.27464,0.807,0.656,145,0.819,"GW.501516, pterostilbene",0.18309616062434,0.0867160982395816,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.33273,-0.82,0.702,751,0.927,"norethindrone, norethindrone.acetate, tanaproget, nomegestrol.acetate, norgestrel",0.153662887870195,0.0329202658555029,FALSE
+"H1975","Pearson.est","proteasome inhibitor",-0.57568,-1.43,0.0838,1355,0.57,"ixazomib, ixazomib.citrate",1.07675598136972,0.244125144327509,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",-0.33721,-0.823,0.696,1027,0.96,"anguidine, puromycin, homoharringtonine, thiostrepton, cycloheximide, mercaptopurine, emetine",0.157390760389438,0.0177287669604316,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",-0.28437,-0.709,0.814,1035,0.98,"rheochrysidin, NVP.TAE226, PP.121",0.0893755951107988,0.00877392430750515,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.30073,0.867,0.58,121,0.769,"vemurafenib, GDC.0879, dabrafenib",0.236572006437063,0.114073660198569,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",-0.531,-1.31,0.166,1284,0.534,"cabozantinib, vandetanib",0.779891911959945,0.272458742971444,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.57105,1.74,0.0287,307,0.327,"adarotene, bexarotene, tamibarotene, adapalene",1.54211810326601,0.485452247339714,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.50581,-1.23,0.226,1236,0.571,"hydroxyurea, fludarabine, clofarabine",0.645891560852599,0.243363891754152,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.52027,-1.27,0.185,1447,0.529,"aripiprazole",0.732828271596986,0.276544327964814,FALSE
+"H1975","Pearson.est","serotonin receptor antagonist",-0.42582,-1.05,0.415,1411,0.773,"RS.16566, aripiprazole",0.381951903287907,0.111820506081675,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.25816,-0.631,0.895,938,0.977,"oxcarbazepine, quinidine, A.803467, mepivacaine",0.048176964684088,0.0101054362812269,FALSE
+"H1975","Pearson.est","src inhibitor",-0.45993,-1.1,0.327,1234,0.755,"masitinib, KX2.391, bosutinib",0.485452247339714,0.122053048370812,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",-0.26733,-0.657,0.88,1315,0.986,"ketoconazole",0.0555173278498314,0.0061230850587888,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.46453,1.32,0.142,171,0.402,"LY2109761, adaprev",0.847711655616944,0.39577394691553,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.6879,2.06,0.018,346,0.171,"capecitabine, doxifluridine, carmofur, raltitrexed",1.74472749489669,0.767003889607846,TRUE
+"H1975","Pearson.est","topoisomerase inhibitor",-0.55425,-1.35,0.121,942,0.528,"irinotecan, SN.38, amsacrine, epirubicin, mitoxantrone, rubitecan, genz.644282, idarubicin, teniposide, valrubicin, etoposide, voreloxin, licochalcone.a, camptothecin, daunorubicin, TAS.103, amonafide",0.91721462968355,0.277366077466188,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",-0.57023,-1.4,0.101,1009,0.552,"paclitaxel, podophyllotoxin, nocodazole, flubendazole, oxibendazole, parbendazole, dolastatin.10, ABT.751, vinblastine, plinabulin, docetaxel, combretastatin.A.4, BNC105, verubulin, KX2.391, epothilone.b, fosbretabulin, epothilone.d",0.995678626217357,0.258060922270801,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",-0.43489,-1.07,0.368,1035,0.776,"rheochrysidin, AMG.208, NVP.TAE226, PP.121, tyrphostin.AG.99, cabozantinib, vandetanib, UNC2250, aminopurvalanol.a",0.434152181326482,0.110138278741812,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",-0.28471,-0.685,0.849,1284,0.974,"cabozantinib, vandetanib, nintedanib, KI.8751, vatalanib, axitinib",0.0710923097560473,0.0114410431213845,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",-0.26526,-0.65,0.886,758,0.976,"tacalcitol, paricalcitol, calcitriol, doxercalciferol, alfacalcidol",0.0525662781129492,0.0105501823333082,FALSE
+"HCC78","Pearson.est","EGFR inhibitor",-0.38566,-0.937,0.574,718,0.791,"BMS.690514, gefitinib, CUDC.101, PD.168393, FERb.033, lapatinib, erlotinib, AEE788, afatinib, icotinib, canertinib, TAK.285, CP.724714, pelitinib, XL.647, tucatinib, brigatinib, vandetanib, osimertinib, neratinib, WZ8040, OSI.420, rociletinib, salvianolic.acid.B, PD.153035, BIBU.1361, BMS.599626",0.241088107602027,0.101823516502323,FALSE
+"HCC78","Pearson.est","Abl kinase inhibitor",-0.59261,-1.42,0.0736,1311,0.785,"ponatinib, bosutinib, tozasertib, GZD824, KW.2449, flumatinib",1.1331221856625,0.105130343254747,FALSE
+"HCC78","Pearson.est","acetylcholine receptor agonist",-0.47941,-1.17,0.271,975,0.694,"pilocarpine, nicotine, tremorine",0.567030709125594,0.158640529545145,FALSE
+"HCC78","Pearson.est","acetylcholine receptor antagonist",-0.57558,-1.39,0.104,986,0.722,"iododexetimide, methscopolamine, dicycloverine, darifenacin",0.98296666070122,0.141462802430361,FALSE
+"HCC78","Pearson.est","adenosine receptor antagonist",-0.47399,-1.14,0.298,1014,0.749,"istradefylline, PSB.1115, sulmazole",0.525783735923745,0.125518182300534,FALSE
+"HCC78","Pearson.est","adrenergic receptor agonist",-0.49877,-1.21,0.229,946,0.667,"oxymetazoline, terbutaline, A61603, midodrine, isoxsuprine, metaraminol, clenbuterol, isoetharine, epinephrine, buphenine",0.640164517660112,0.175874166083451,FALSE
+"HCC78","Pearson.est","adrenergic receptor antagonist",-0.19873,-0.484,0.978,610,1,"atipamezole, propranolol, oxprenolol, levobunolol, vincamine, carvedilol, pindolol, idazoxan, atenolol...., dronedarone",0.00966114521239857,0,FALSE
+"HCC78","Pearson.est","AKT inhibitor",-0.29856,-0.729,0.816,849,0.919,"AT7867, triciribine, uprosertib, AZD5363, palomid.529, CCT128930",0.0883098412461389,0.0366844886138887,FALSE
+"HCC78","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.56326,-1.36,0.108,1009,0.508,"AP26113, GW.788388, brigatinib, alectinib, DMH1, CEP.37440, AZD3463",0.96657624451305,0.294136287716081,FALSE
+"HCC78","Pearson.est","androgen receptor antagonist",-0.36252,-0.883,0.618,770,0.828,"bicalutamide, cyproterone.acetate, flutamide",0.209011524911184,0.0819696632151199,FALSE
+"HCC78","Pearson.est","antioxidant",-0.43787,-1.04,0.414,794,0.678,"rutin, mesna, benfotiamine, taurine",0.382999658879101,0.168770306132937,FALSE
+"HCC78","Pearson.est","AP inhibitor",0.31797,0.958,0.5,29,0.803,"birinapant",0.301029995663981,0.095284454721319,FALSE
+"HCC78","Pearson.est","ATPase inhibitor",0.41393,1.22,0.218,72,0.636,"k.strophanthidin, rabeprazole",0.661543506395395,0.196542884351586,FALSE
+"HCC78","Pearson.est","Aurora kinase inhibitor",-0.53253,-1.27,0.159,983,0.591,"PF.03814735, barasertib, CYC116, CCT137690, danusertib, barasertib.HQPA, MK.8745, AT.9283, ZM.447439, alisertib, ENMD.2076, hesperadin, tozasertib, SNS.314, KW.2449",0.798602875679548,0.228412519118745,FALSE
+"HCC78","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.56946,-1.37,0.104,1319,0.557,"azalomycin.b, tedizolid, dirithromycin",0.98296666070122,0.254144804826271,FALSE
+"HCC78","Pearson.est","bacterial DNA gyrase inhibitor",-0.26705,-0.647,0.911,1168,0.987,"novobiocin, sarafloxacin",0.0404816230270017,0.00568284733036327,FALSE
+"HCC78","Pearson.est","BCL inhibitor",-0.36057,-0.865,0.658,780,0.813,"ABT.737, HA14.1, TW.37, gossypol, navitoclax",0.181774106386044,0.0899094544059319,FALSE
+"HCC78","Pearson.est","Bcr.Abl kinase inhibitor",-0.58483,-1.42,0.0919,898,0.785,"metatinib, imatinib, dasatinib, nilotinib, ponatinib, bosutinib, tozasertib, GZD824, flumatinib",1.03668448861389,0.105130343254747,FALSE
+"HCC78","Pearson.est","benzodiazepine receptor agonist",0.3131,0.931,0.516,66,0.78,"bentazepam, ivermectin, eprinomectin",0.287350298372789,0.10790539730952,FALSE
+"HCC78","Pearson.est","bromodomain inhibitor",-0.80106,-1.93,0,1307,0.0703,"PFI.1, bromosporine, I.BET151, JQ1...., I.BET.762",Inf,1.15304467498018,TRUE
+"HCC78","Pearson.est","calcium channel blocker",-0.39792,-0.97,0.52,808,0.774,"tetrandrine, pranidipine, SKF.96365, efonidipine.monoethanolate, penfluridol, mibefradil",0.283996656365201,0.111259039317107,FALSE
+"HCC78","Pearson.est","CC chemokine receptor antagonist",-0.35441,-0.867,0.655,730,0.825,"UNBS.5162, PF.04136309, SB.225002, navarixin, MK.0812, RS.504393",0.183758700008217,0.0835460514500749,FALSE
+"HCC78","Pearson.est","CDK inhibitor",-0.58271,-1.38,0.0988,1088,0.571,"dinaciclib, BMS.387032, PHA.793887, AT.7519, PHA.848125, aminopurvalanol.a, kenpaullone, BMS.265246, P276.00, AZD5438, TG.02, ribociclib, palbociclib, JNJ.7706621, abemaciclib",1.00524305541237,0.243363891754152,FALSE
+"HCC78","Pearson.est","CHK inhibitor",-0.42893,-1.05,0.413,891,0.673,"LY2606368, AZD7762, PF.477736, SB.218078",0.384049948343599,0.171984935776023,FALSE
+"HCC78","Pearson.est","cyclooxygenase inhibitor",-0.35218,-0.843,0.666,1154,0.82,"ketoprofen, suxibuzone, ramifenazone, aspirin, FR.122047, piroxicam, phenazone",0.176525770829699,0.0861861476162833,FALSE
+"HCC78","Pearson.est","cytochrome P450 inhibitor",-0.38458,-0.933,0.564,1140,0.768,"eplerenone, morin, itraconazole",0.248720896016658,0.114638779968488,FALSE
+"HCC78","Pearson.est","DNA alkylating agent",-0.42685,-1.03,0.414,1132,0.682,"cisplatin, ifosfamide, streptozotocin, TH.302, estramustine",0.382999658879101,0.166215625343521,FALSE
+"HCC78","Pearson.est","DNA inhibitor",-0.18285,-0.438,0.996,1402,0.993,"primaquine",0.00174066157630127,0.00305075150461883,FALSE
+"HCC78","Pearson.est","DNA methyltransferase inhibitor",-0.49179,-1.18,0.249,828,0.722,"azacitidine, RG108, fdcyd, decitabine, SGI.1027",0.603800652904264,0.141462802430361,FALSE
+"HCC78","Pearson.est","DNA polymerase inhibitor",-0.44452,-1.07,0.37,1325,0.68,"idoxuridine, trifluridine",0.431798275933005,0.167491087293764,FALSE
+"HCC78","Pearson.est","DNA synthesis inhibitor",-0.21825,-0.522,0.98,597,1,"mitomycin.c, azodicarbonamide, CB.10.277, anisomycin, floxuridine, capecitabine, enocitabine, cisplatin, cyclocytidine",0.00877392430750515,0,FALSE
+"HCC78","Pearson.est","dopamine receptor antagonist",0.22906,0.677,0.834,110,0.925,"clebopride, oxiperomide, thioproperazine, domperidone",0.0788339493622613,0.0338582672609674,FALSE
+"HCC78","Pearson.est","estrogen receptor agonist",-0.2529,-0.607,0.918,845,1,"estrone, estradiol.cypionate, PPT, estradiol",0.0371573187987575,0,FALSE
+"HCC78","Pearson.est","estrogen receptor antagonist",-0.38212,-0.936,0.551,1093,0.777,"tamoxifen, danazol, clomifene",0.258848401148215,0.109578981199086,FALSE
+"HCC78","Pearson.est","FGFR inhibitor",-0.57521,-1.39,0.0958,1078,0.722,"PD.173074, AZD4547, MK.2461, lucitanib, nintedanib",1.01863449092146,0.141462802430361,FALSE
+"HCC78","Pearson.est","FLT3 inhibitor",-0.55121,-1.33,0.117,1226,0.555,"lestaurtinib, tandutinib, ponatinib, ENMD.2076, TG.02, tozasertib, KW.2449, gilteritinib",0.931814138253838,0.255707016877324,FALSE
+"HCC78","Pearson.est","glucocorticoid receptor agonist",0.35596,1.07,0.383,83,0.744,"hydrocortisone, triamcinolone.acetonide, piretanide, desonide",0.416801226031377,0.128427064454121,FALSE
+"HCC78","Pearson.est","glutamate receptor antagonist",0.16948,0.522,0.968,84,0.978,"MTPG, latrepirdine",0.0141246426916063,0.00966114521239857,FALSE
+"HCC78","Pearson.est","glycogen synthase kinase inhibitor",-0.45054,-1.1,0.338,850,0.751,"GSK.3.inhibitor.IX, tideglusib, LY2090314, CHIR.99021, kenpaullone",0.471083299722345,0.124360062995832,FALSE
+"HCC78","Pearson.est","growth factor receptor inhibitor",-0.71742,-1.73,0.0104,1096,0.3,"danusertib, PHA.848125, lestaurtinib, GSK1904529A, AZD3463, GSK1838705A",1.98296666070122,0.522878745280338,FALSE
+"HCC78","Pearson.est","HCV inhibitor",-0.32161,-0.769,0.784,996,0.9,"daclatasvir, narlaprevir, mericitabine",0.105683937315562,0.0457574905606751,FALSE
+"HCC78","Pearson.est","HDAC inhibitor",-0.51485,-1.26,0.183,1172,0.587,"RGFP966, givinostat, belinostat, trichostatin.a, vorinostat, AR.42, dacinostat, resminostat, M.344, R306465, RG2833",0.737548910269571,0.231361898752386,FALSE
+"HCC78","Pearson.est","histamine receptor antagonist",-0.31342,-0.76,0.778,1121,0.896,"cimetidine, ICI.162846, BF2.649, ebastine, tiotidine",0.109020403010311,0.0476919903378748,FALSE
+"HCC78","Pearson.est","HMGCR inhibitor",0.46394,1.38,0.109,779,0.453,"fluvastatin, mevastatin, simvastatin, atorvastatin, pitavastatin, lovastatin",0.962573502059376,0.343901797987168,FALSE
+"HCC78","Pearson.est","HSP inhibitor",-0.41759,-1.02,0.445,1021,0.687,"NVP.AUY922, VER.49009, SNX.2112, SNX.5422, XL888",0.351639989019068,0.16304326294045,FALSE
+"HCC78","Pearson.est","JAK inhibitor",-0.58368,-1.38,0.0958,882,0.571,"TG.101209, filgotinib, atiprimod, AZ960, WHI.P154, pacritinib, AZD1480, baricitinib, lestaurtinib, PRT062070, AT.9283, TG.02, tozasertib",1.01863449092146,0.243363891754152,FALSE
+"HCC78","Pearson.est","KIT inhibitor",-0.52623,-1.27,0.176,856,0.591,"sorafenib, telatinib, motesanib, regorafenib, sunitinib, OSI.930, imatinib, dasatinib, pazopanib, tandutinib, KI.8751, masitinib, vatalanib",0.75448733218585,0.228412519118745,FALSE
+"HCC78","Pearson.est","MDM inhibitor",0.457,1.39,0.0994,789,0.582,"idasanutlin, RITA, serdemetan, AMG.232, nutlin.3, CGM097",1.00261361560269,0.235077015350112,FALSE
+"HCC78","Pearson.est","MEK inhibitor",-0.3888,-0.926,0.576,1322,0.766,"arctigenin, trametinib, cobimetinib, nobiletin",0.239577516576788,0.115771230367396,FALSE
+"HCC78","Pearson.est","MET inhibitor",-0.62142,-1.48,0.0505,1033,0.953,"LY2801653, AMG458, NVP.BVU972, INC.280, PHA.665752",1.29670862188134,0.0209070993616736,FALSE
+"HCC78","Pearson.est","microtubule inhibitor",-0.46391,-1.12,0.335,963,0.749,"cabazitaxel, secnidazole, cytochalasin.b, D.64131",0.474955192963155,0.125518182300534,FALSE
+"HCC78","Pearson.est","mTOR inhibitor",0.34814,1.04,0.437,99,0.713,"torin.1, PP242, SB.2343, sirolimus, WAY.600, PKI.179, PF.05212384",0.359518563029578,0.146910470148134,FALSE
+"HCC78","Pearson.est","NFkB pathway inhibitor",-0.56902,-1.38,0.0972,1426,0.571,"bortezomib, Ro.106.9920, betulinic.acid",1.01233373507373,0.243363891754152,FALSE
+"HCC78","Pearson.est","opioid receptor agonist",-0.56559,-1.36,0.112,1156,0.508,"salvinorin.a, trimebutine",0.950781977329818,0.294136287716081,FALSE
+"HCC78","Pearson.est","p38 MAPK inhibitor",-0.45068,-1.09,0.345,1010,0.689,"VX.702, skepinone.l, SB.239063",0.462180904926726,0.161780778092374,FALSE
+"HCC78","Pearson.est","PARP inhibitor",-0.49192,-1.17,0.26,841,0.694,"AZD2461, niraparib, olaparib, PJ.34, talazoparib",0.585026652029182,0.158640529545145,FALSE
+"HCC78","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.44687,-1.09,0.36,912,0.689,"telatinib, motesanib, regorafenib, sunitinib, imatinib, dasatinib, pazopanib, crenolanib, tandutinib, ponatinib, KI.8751, masitinib, nintedanib, vatalanib, CP.673451",0.443697499232713,0.161780778092374,FALSE
+"HCC78","Pearson.est","phosphatase inhibitor",0.26634,0.796,0.653,1065,0.823,"bis.maltolato.oxovanadium.IV., mycophenolate.mofetil, sodium.stibogluconate, mycophenolic.acid, GSK2830371, alexidine, BVT.948, AS.1949490, menadione, CID.5458317",0.185086818724926,0.0846001647877302,FALSE
+"HCC78","Pearson.est","phosphodiesterase inhibitor",-0.43414,-1.05,0.394,1253,0.673,"EMD.53998, trequinsin, GSK256066",0.404503778174426,0.171984935776023,FALSE
+"HCC78","Pearson.est","PI3K inhibitor",-0.19103,-0.464,0.986,874,1,"CH5132799, ZSTK.474, GSK2126458, taselisib, alpelisib, buparlisib, TG100.115, PIK.75, LY303511, TG.100713",0.0061230850587888,0,FALSE
+"HCC78","Pearson.est","PLK inhibitor",-0.60771,-1.47,0.0604,1051,0.814,"NMS.1286937, GSK461364, BI.2536, GW.843682X, volasertib",1.21896306137887,0.0893755951107988,FALSE
+"HCC78","Pearson.est","potassium channel blocker",-0.47012,-1.13,0.328,1381,0.75,"mepivacaine",0.484126156288321,0.1249387366083,FALSE
+"HCC78","Pearson.est","PPAR receptor agonist",0.38625,1.15,0.252,10,0.674,"pterostilbene",0.598599459218456,0.17134010346468,FALSE
+"HCC78","Pearson.est","progesterone receptor agonist",0.47657,1.48,0.0676,164,0.628,"levonorgestrel, norethindrone, norgestrel, norethindrone.acetate, tanaproget",1.17005330405836,0.202040356262804,FALSE
+"HCC78","Pearson.est","proteasome inhibitor",-0.446,-1.07,0.387,1155,0.68,"ixazomib, carfilzomib, bortezomib",0.412289034981089,0.167491087293764,FALSE
+"HCC78","Pearson.est","protein synthesis inhibitor",0.27161,0.829,0.607,129,0.838,"clofoctol, chloramphenicol.palmitate, methacycline, cycloheximide",0.216811308924742,0.0767559813697235,FALSE
+"HCC78","Pearson.est","protein tyrosine kinase inhibitor",-0.45515,-1.09,0.364,877,0.689,"tyrphostin.A9, CP.724714, rheochrysidin, NVP.TAE226, BMS.599626",0.438898616350944,0.161780778092374,FALSE
+"HCC78","Pearson.est","RAF inhibitor",-0.51102,-1.23,0.198,856,0.64,"sorafenib, LGX818, AZ.628, regorafenib, CEP.32496, PLX.4720, dabrafenib, TAK.632, GDC.0879, RAF265",0.703334809738469,0.193820026016113,FALSE
+"HCC78","Pearson.est","RET tyrosine kinase inhibitor",-0.53745,-1.29,0.144,775,0.634,"apatinib, sorafenib, regorafenib, sunitinib, vandetanib, cabozantinib",0.84163750790475,0.197910742118267,FALSE
+"HCC78","Pearson.est","retinoid receptor agonist",0.29019,0.832,0.66,225,0.909,"adapalene, bexarotene, fenretinide, LE.135",0.180456064458131,0.0414361167780325,FALSE
+"HCC78","Pearson.est","ribonucleotide reductase inhibitor",-0.33296,-0.796,0.751,523,0.877,"triapine, gemcitabine, LY2334737, cladribine, fludarabine.phosphate, pentostatin, hydroxyurea, fludarabine, clofarabine",0.124360062995832,0.0570004066339595,FALSE
+"HCC78","Pearson.est","serotonin receptor agonist",-0.35272,-0.85,0.698,1377,0.824,"ipsapirone",0.156144577376839,0.0840727883028842,FALSE
+"HCC78","Pearson.est","serotonin receptor antagonist",-0.39145,-0.957,0.533,1038,0.783,"ziprasidone, paliperidone, SB.216641, SB.228357, RS.16566",0.273272790973428,0.106238237942057,FALSE
+"HCC78","Pearson.est","sodium channel blocker",-0.44199,-1.06,0.391,991,0.685,"oxcarbazepine, triamterene, butamben, lappaconite, ajmaline, mepivacaine, quinidine",0.407823242604133,0.164309428507574,FALSE
+"HCC78","Pearson.est","src inhibitor",-0.61449,-1.48,0.0641,1025,0.953,"PP.2, dasatinib, saracatinib, bosutinib, masitinib, TG.100572, PP.1",1.19314197048118,0.0209070993616736,FALSE
+"HCC78","Pearson.est","sterol demethylase inhibitor",0.53762,1.6,0.06,201,0.789,"terconazole, sulconazole, lanoconazole, ketoconazole",1.22184874961636,0.10292299679058,FALSE
+"HCC78","Pearson.est","TGF beta receptor inhibitor",-0.46705,-1.11,0.339,776,0.75,"SB.431542, LY2109761, repsox, D.4476",0.469800301796918,0.1249387366083,FALSE
+"HCC78","Pearson.est","thymidylate synthase inhibitor",-0.52453,-1.27,0.181,807,0.591,"doxifluridine, carmofur, capecitabine, raltitrexed, trifluridine",0.742321425130815,0.228412519118745,FALSE
+"HCC78","Pearson.est","topoisomerase inhibitor",-0.3689,-0.878,0.658,907,0.822,"rubitecan, valrubicin, etoposide.phosphate, genz.644282, amonafide, topotecan, fleroxacin, irinotecan, SN.38, exatecan.mesylate, etoposide, licochalcone.a, daunorubicin",0.181774106386044,0.0851281824599496,FALSE
+"HCC78","Pearson.est","tubulin polymerization inhibitor",-0.19751,-0.473,0.988,772,1,"vindesine, combretastatin.A.4, epothilone.b, parbendazole, flubendazole, albendazole, fosbretabulin, docetaxel, paclitaxel",0.00524305541237188,0,FALSE
+"HCC78","Pearson.est","tyrosine kinase inhibitor",-0.39783,-0.951,0.538,856,0.779,"sorafenib, UNC2250, tyrphostin.A9, regorafenib, sunitinib, CP.724714, dasatinib, rheochrysidin, vandetanib, cabozantinib, aminopurvalanol.a, hypericin, NVP.TAE226, tivantinib, BMS.599626",0.269217724333611,0.108462542327436,FALSE
+"HCC78","Pearson.est","VEGFR inhibitor",-0.4503,-1.09,0.344,912,0.689,"telatinib, motesanib, regorafenib, sunitinib, OSI.930, XL.647, PD.173074, pazopanib, tivozanib, vandetanib, cabozantinib, KI.8751, ENMD.2076, MK.2461, lucitanib, nintedanib, RAF265, vatalanib, TG.100572, golvatinib, foretinib",0.46344155742847,0.161780778092374,FALSE
+"HCC78","Pearson.est","vitamin D receptor agonist",-0.45799,-1.08,0.366,1144,0.693,"alfacalcidol, tacalcitol",0.436518914605589,0.159266765388193,FALSE
+"H2126","Pearson.est","EGFR inhibitor",0.36732,0.877,0.632,615,0.949,"BMS.599626, BIBU.1361, BMS.690514, CUDC.101, dovitinib, CGP.52411, brigatinib, CP.724714, rociletinib, XL.647, vandetanib, tyrphostin.AG.494, salvianolic.acid.B, AZD8931, tucatinib, afatinib, osimertinib, AEE788, PD.153035, neratinib, dacomitinib, OSI.420, TAK.285",0.199282921717615,0.0227337875727074,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",0.6241,1.48,0.0778,381,0.312,"GZD824, flumatinib, bafetinib, KW.2449, dasatinib, nilotinib, metatinib, ponatinib",1.10902040301031,0.505845405981557,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",0.35207,0.844,0.656,104,0.946,"tremorine",0.18309616062434,0.0241088635982073,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",0.48713,1.16,0.286,685,0.814,"dicycloverine, darifenacin, iododexetimide, methscopolamine",0.543633966870957,0.0893755951107988,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.40061,-1.11,0.326,1389,0.617,"istradefylline, theophylline",0.486782399932061,0.209714835966758,FALSE
+"H2126","Pearson.est","adrenergic receptor agonist",0.52509,1.27,0.197,433,0.631,"oxymetazoline, buphenine, clenbuterol, metaraminol, epinephrine, isoetharine, xylazine",0.705533773838407,0.199970640755866,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",0.33374,0.798,0.709,492,0.969,"atenolol...., propranolol, practolol, dronedarone, RS.17053, pindolol, carvedilol, atipamezole",0.149353764816933,0.0136762229492347,FALSE
+"H2126","Pearson.est","AKT inhibitor",0.29672,0.728,0.804,414,1,"CCT128930, uprosertib, GDC.0068, palomid.529",0.0947439512515487,0,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.54476,1.3,0.178,458,0.619,"DMH1, CEP.37440, SB.505124, NVP.TAE684, AZD3463, brigatinib, GW.788388",0.749579997691106,0.208309350979882,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",0.44416,1.08,0.356,229,0.73,"cyproterone.acetate, flutamide",0.448550002027125,0.136677139879544,FALSE
+"H2126","Pearson.est","antioxidant",0.27076,0.64,0.896,340,1,"mesna, benfotiamine",0.0476919903378748,0,FALSE
+"H2126","Pearson.est","AP inhibitor",-0.55743,-1.52,0.0921,1274,0.503,"birinapant, embelin",1.03574036980315,0.298432014944073,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.29333,0.719,0.8,400,0.977,"thonzonium, evodiamine, blebbistatin...., NMS.873",0.0969100130080564,0.0101054362812269,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.16615,0.405,0.996,716,0.997,"KW.2449, CCT137690, alisertib, ZM.447439, ENMD.2076, SNS.314, CCT129202, danusertib, MK.5108, tozasertib, barasertib, AT.9283, barasertib.HQPA",0.00174066157630127,0.00130484168834428,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.64834,1.57,0.0364,293,0.274,"tedizolid, azalomycin.b, josamycin, dirithromycin",1.43889861635094,0.562249437179612,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.33783,0.812,0.694,371,0.965,"sparfloxacin, sarafloxacin, novobiocin, trovafloxacin",0.158640529545145,0.0154726866562074,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.46583,1.12,0.332,260,0.79,"oridonin, navitoclax, gossypol, ABT.737",0.478861916295964,0.102372908709559,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.64612,1.57,0.0493,381,0.274,"GZD824, flumatinib, bafetinib, dasatinib, nilotinib, metatinib, ponatinib",1.30715308072277,0.562249437179612,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",0.27708,0.672,0.839,9,1,"ZK.93423",0.0762380391712997,0,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",0.55749,1.34,0.158,557,0.551,"JQ1...., PFI.1, I.BET151, I.BET.762, OTX015",0.801342913045577,0.258848401148215,FALSE
+"H2126","Pearson.est","calcium channel blocker",0.44482,1.07,0.377,186,0.729,"penfluridol, SKF.96365, efonidipine.monoethanolate",0.423658649794207,0.137272471682025,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.67789,1.61,0.0249,273,0.302,"UNBS.5162, SB.225002, RS.504393, PF.04136309",1.60380065290426,0.519993057042849,FALSE
+"H2126","Pearson.est","CDK inhibitor",0.38288,0.899,0.588,549,0.951,"JNJ.7706621, AZD5438, BMS.387032, PHA.848125, kenpaullone, palbociclib, abemaciclib, ribociclib, indisulam, PHA.793887, R547",0.230622673923862,0.0218194830625861,FALSE
+"H2126","Pearson.est","CHK inhibitor",-0.74766,-2.05,0.0102,1334,0.1,"SCH.900776, AZD7762, CHIR.124, LY2603618",1.99139982823808,1,TRUE
+"H2126","Pearson.est","cyclooxygenase inhibitor",0.30835,0.742,0.816,387,1,"phenazone, ramifenazone, piroxicam, aspirin, phenylbutazone, curcumin, suxibuzone",0.0883098412461389,0,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",0.49505,1.19,0.262,361,0.771,"morin, itraconazole, clotrimazole, eplerenone",0.581698708680255,0.112945621949043,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.36017,0.874,0.626,245,0.933,"estramustine, carmustine, TH.302",0.20342566678957,0.0301183562535,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.4437,1.08,0.365,251,0.73,"carmustine, oxaliplatin, mechlorethamine, primaquine",0.437707135543525,0.136677139879544,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",0.45846,1.11,0.324,321,0.76,"SGI.1027, decitabine, fdcyd",0.489454989793388,0.119186407719209,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",-0.34344,-0.961,0.478,1413,0.603,"cidofovir",0.320572103387881,0.219682687859849,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",-0.39245,-1.06,0.34,1153,0.642,"artesunate, enocitabine, anisomycin, altretamine",0.468521082957745,0.192464971931147,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.2781,-0.758,0.752,1198,0.748,"thioproperazine, acetophenazine, piperacetazine, raclopride, oxiperomide, remoxipride",0.123782159408358,0.126098402135539,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",-0.51476,-1.44,0.107,1327,0.399,"equol, PPT, levonorgestrel",0.97061622231479,0.399027104313252,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",-0.37431,-1,0.418,1428,0.634,"raloxifene",0.378823718224965,0.197910742118267,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.62353,1.49,0.0698,306,0.315,"nintedanib, MK.2461, PD.173074, lucitanib, erdafitinib, dovitinib",1.15614457737684,0.501689446210399,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.4724,1.13,0.307,399,0.796,"tandutinib, gilteritinib, KW.2449, dovitinib, sunitinib, ponatinib, ENMD.2076",0.512861624522813,0.0990869322623309,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",-0.45798,-1.24,0.212,1167,0.536,"methylprednisolone, dexamethasone.acetate, ciclesonide, deflazacort, difluprednate, fluorometholone, desonide, hydrocortisone",0.673664139071249,0.27083521030723,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",0.48031,1.14,0.288,131,0.802,"JNJ.16259685, felbamate, kynurenic.acid, diazooxonorleucine",0.540607512240769,0.0958256317158365,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",0.69629,1.67,0.0188,343,0.277,"GSK.3.inhibitor.IX, LY2090314, CHIR.98014, kenpaullone, CHIR.99021, tideglusib",1.72584215073632,0.557520230935551,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.64015,1.54,0.0575,353,0.302,"GSK1838705A, GSK1904529A, PHA.848125, AZD3463",1.24033215531037,0.519993057042849,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.35746,0.88,0.599,172,0.966,"narlaprevir, daclatasvir",0.222573177610689,0.0150228735845067,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.35084,-0.939,0.494,1264,0.597,"scriptaid, NSC.3852, ACY.1215, entinostat, JNJ.26481585, mocetinostat, tacedinaline",0.306273051076353,0.224025668870631,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",0.30079,0.724,0.804,504,0.989,"ICI.162846, ebastine, chloropyramine, cyproheptadine, nizatidine, BF2.649, lafutidine",0.0947439512515487,0.0048037084028206,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",-0.3597,-0.992,0.456,1109,0.598,"lovastatin, mevastatin, fluvastatin",0.341035157335565,0.223298816011589,FALSE
+"H2126","Pearson.est","HSP inhibitor",0.22475,0.527,0.958,666,1,"SNX.5422, XL888, NMS.E973, guanidine, tanespimycin, NVP.AUY922, SNX.2112, KW.2478",0.0186344909214556,0,FALSE
+"H2126","Pearson.est","JAK inhibitor",0.2379,0.577,0.937,767,1,"filgotinib, baricitinib, AZD1480, AZ960, CEP.33779, WHI.P154, pacritinib, ruxolitinib, tozasertib, AT.9283, TG.02, TG.101348, atiprimod",0.0282604091122217,0,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.45787,1.09,0.356,540,0.755,"masitinib, OSI.930, tandutinib, motesanib, dasatinib, sunitinib, pazopanib, imatinib, vatalanib",0.448550002027125,0.122053048370812,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.54119,-1.48,0.0945,1319,0.431,"idasanutlin, RITA",1.02456819149074,0.365522729839268,FALSE
+"H2126","Pearson.est","MEK inhibitor",0.38746,0.921,0.55,274,0.928,"cobimetinib, arctigenin, trametinib, AZD8330",0.259637310505756,0.0324520237811379,FALSE
+"H2126","Pearson.est","MET inhibitor",0.79219,1.92,0.00141,289,0.118,"PHA.665752, INC.280, LY2801653, NVP.BVU972, AMG458",2.85078088734462,0.928117992693875,TRUE
+"H2126","Pearson.est","microtubule inhibitor",0.24948,0.595,0.951,506,1,"vinflunine, cytochalasin.b, vinblastine, D.64131",0.0218194830625861,0,FALSE
+"H2126","Pearson.est","mTOR inhibitor",-0.3029,-0.799,0.683,1136,0.732,"deforolimus, LY303511, LY3023414, PP242, PKI.179, sirolimus, SB.2343, PI.103, WAY.600, torin.1",0.165579296318467,0.135488918941608,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",0.43063,1.04,0.405,92,0.77,"Ro.106.9920, bortezomib, betulinic.acid",0.392544976785331,0.113509274827518,FALSE
+"H2126","Pearson.est","opioid receptor agonist",0.32699,0.789,0.729,145,0.965,"trimebutine",0.137272471682025,0.0154726866562074,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",0.71829,1.72,0.00836,25,0.31,"skepinone.l, SB.239063",2.07779372256098,0.508638306165727,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.42992,1.03,0.425,1,0.769,"PJ.34",0.371611069949688,0.114073660198569,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.40073,0.951,0.518,540,0.889,"masitinib, nintedanib, tandutinib, CP.673451, motesanib, dovitinib, dasatinib, sunitinib, ponatinib, pazopanib, crenolanib, imatinib, vatalanib",0.285670240254767,0.0510982390297863,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.34014,0.828,0.675,238,0.956,"alexidine, sodium.stibogluconate, BVT.948",0.170696227168975,0.0195421077238999,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",0.25902,0.615,0.912,552,1,"EMD.53998, enoximone, zardaverine, YM.976, trequinsin",0.0400051616715838,0,FALSE
+"H2126","Pearson.est","PI3K inhibitor",0.29202,0.706,0.82,370,0.977,"buparlisib, CH5132799, PIK.75, GSK2126458, BGT226, PI.828, TG.100713, TG100.115, PF.04691502",0.0861861476162833,0.0101054362812269,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.65187,1.53,0.0532,431,0.271,"volasertib, GW.843682X, rigosertib, BI.2536",1.27408836770495,0.567030709125594,FALSE
+"H2126","Pearson.est","potassium channel blocker",0.27607,0.655,0.879,463,1,"mepivacaine, ML133, dofetilide",0.0560111249262281,0,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",-0.36302,-1.04,0.383,1220,0.616,"clofibrate, fenofibrate, pterostilbene",0.416801226031377,0.210419287835575,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",-0.62574,-1.64,0.0692,1261,0.482,"norgestrel, norethindrone.acetate, levonorgestrel, norethindrone",1.15989390554324,0.31695296176115,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.73338,1.76,0.00986,295,0.321,"bortezomib, oprozomib, carfilzomib, ixazomib, MG.132, ixazomib.citrate",2.00612308505879,0.493494967595128,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",-0.43829,-1.16,0.278,1154,0.597,"emetine, brefeldin.a, harringtonine, homoharringtonine, chloramphenicol.palmitate, anguidine, bruceantin, cycloheximide",0.555955204081924,0.224025668870631,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",0.3997,0.959,0.514,403,0.895,"BMS.599626, tyrphostin.A9, mubritinib, CP.724714",0.289036881004724,0.048176964684088,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.65824,1.57,0.0506,248,0.274,"LGX818, dabrafenib, GDC.0879, RAF265, SB.590885, PLX.4720",1.2958494831602,0.562249437179612,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.50705,1.24,0.222,440,0.673,"sunitinib, cabozantinib, vandetanib, apatinib",0.653647025549361,0.171984935776023,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.32386,0.775,0.732,565,0.969,"CD.437, AM.580, tamibarotene, fenretinide, adapalene",0.135488918941608,0.0136762229492347,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.21894,0.527,0.971,647,1,"cytarabine, triapine, hydroxyurea, LY2334737",0.0127807700919951,0,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",0.52638,1.27,0.192,620,0.631,"pardoprunox, ipsapirone, NAN.190, aripiprazole",0.71669877129645,0.199970640755866,FALSE
+"H2126","Pearson.est","serotonin receptor antagonist",0.35608,0.859,0.648,659,0.939,"paliperidone, sertindole, lurasidone, SB.200646, ziprasidone, RS.16566, aripiprazole, lerisetron, pirenperone",0.188424994129407,0.0273344077338891,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.48395,1.15,0.303,589,0.808,"ajmaline, mepivacaine, lappaconite, quinidine, oxcarbazepine, benzocaine, benzethonium, brivaracetam, mexiletine",0.518557371497695,0.0925886392254138,FALSE
+"H2126","Pearson.est","src inhibitor",0.62977,1.53,0.0632,320,0.271,"TG.100572, masitinib, PP.1, saracatinib, dasatinib",1.19928292171761,0.567030709125594,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",-0.49121,-1.32,0.155,1322,0.487,"lanoconazole, ketoconazole, terconazole",0.809668301829709,0.312471038785366,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",0.68025,1.65,0.0263,162,0.264,"D.4476, LY2109761, repsox",1.58004425151024,0.578396073130169,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.686,1.68,0.0159,146,0.32,"raltitrexed, trifluridine",1.79860287567955,0.494850021680094,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.58211,1.37,0.127,84,0.507,"topotecan, SN.38, etoposide.phosphate, rubitecan, irinotecan, exatecan.mesylate",0.896196279044043,0.294992040666664,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.21287,0.512,0.978,407,0.991,"flubendazole, parbendazole, docetaxel, paclitaxel, vindesine, fosbretabulin, albendazole, vinblastine",0.00966114521239857,0.00392634551472468,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",0.46719,1.1,0.36,440,0.757,"BMS.599626, tivantinib, bafetinib, tyrphostin.A9, hypericin, dasatinib, mubritinib, sunitinib, cabozantinib, CP.724714, vandetanib, apatinib",0.443697499232713,0.120904120499927,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",0.46834,1.11,0.348,422,0.76,"TG.100572, foretinib, OSI.930, nintedanib, golvatinib, RAF265, MK.2461, PD.173074, BMS.690514, lucitanib, tivozanib, motesanib, dovitinib, sunitinib, cabozantinib, ENMD.2076, pazopanib, XL.647, vandetanib",0.458420756053419,0.119186407719209,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.29394,-0.806,0.713,1268,0.768,"doxercalciferol, paricalcitol",0.146910470148134,0.114638779968488,FALSE
+"HCC827","Pearson.est","EGFR inhibitor",-0.23095,-0.564,0.949,745,1,"CP.724714, salvianolic.acid.B, erlotinib, gefitinib, osimertinib, dacomitinib, pelitinib, BIBU.1361, GW.583340, afatinib, CNX.2006, WZ.4002, icotinib, canertinib, BMS.599626, CGP.52411, tyrphostin.AG.1478, PD.153035, TAK.285, vandetanib, OSI.420, WZ8040, rociletinib",0.0227337875727074,0,FALSE
+"HCC827","Pearson.est","Abl kinase inhibitor",-0.48707,-1.21,0.246,946,0.669,"nilotinib, flumatinib, ponatinib, GZD824, bosutinib, tozasertib, KW.2449",0.609064892896621,0.174573882232177,FALSE
+"HCC827","Pearson.est","acetylcholine receptor agonist",-0.55002,-1.36,0.123,934,0.643,"tremorine, pilocarpine, nicotine",0.910094888560602,0.191789027075778,FALSE
+"HCC827","Pearson.est","acetylcholine receptor antagonist",0.27341,0.773,0.722,155,1,"darifenacin, diphemanil",0.141462802430361,0,FALSE
+"HCC827","Pearson.est","adenosine receptor antagonist",-0.23167,-0.585,0.933,959,1,"istradefylline, sulmazole, theophylline",0.0301183562535,0,FALSE
+"HCC827","Pearson.est","adrenergic receptor agonist",-0.28126,-0.703,0.82,822,0.959,"xylazine, norepinephrine, terbutaline, midodrine, oxymetazoline, A61603, clenbuterol, epinephrine, isoetharine",0.0861861476162833,0.0181813928293364,FALSE
+"HCC827","Pearson.est","adrenergic receptor antagonist",0.24584,0.702,0.822,87,0.979,"prazosin, practolol, atenolol....",0.0851281824599496,0.00921730819686218,FALSE
+"HCC827","Pearson.est","AKT inhibitor",-0.32319,-0.807,0.705,898,0.95,"A.674563, palomid.529, uprosertib, AT7867, triciribine, CCT128930",0.151810883008601,0.0222763947111523,FALSE
+"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33063,0.938,0.531,47,0.962,"SB.505124, NVP.TAE684",0.274905478918531,0.0168249279621871,FALSE
+"HCC827","Pearson.est","androgen receptor antagonist",-0.5701,-1.42,0.0851,907,0.644,"bicalutamide, nilutamide, flutamide, RU.58841",1.07007043991541,0.191114132640188,FALSE
+"HCC827","Pearson.est","antioxidant",-0.59243,-1.48,0.0646,1086,0.611,"chlorogenic.acid, mesna, benfotiamine, taurine",1.18976748200492,0.213958789757446,FALSE
+"HCC827","Pearson.est","AP inhibitor",0.50527,1.42,0.113,226,0.481,"birinapant, tanshinone.i",0.94692155651658,0.317854923626168,FALSE
+"HCC827","Pearson.est","ATPase inhibitor",0.50108,1.43,0.133,270,0.699,"k.strophanthidin, NMS.873, rabeprazole, ouabain, evodiamine, oligomycin.a",0.876148359032914,0.155522824254319,FALSE
+"HCC827","Pearson.est","Aurora kinase inhibitor",-0.61165,-1.53,0.0577,1063,0.542,"GSK1070916, ENMD.2076, AMG900, TAK.901, MK.5108, AT.9283, SNS.314, tozasertib, alisertib, MLN.8054, CYC116, KW.2449, PF.03814735, hesperadin",1.23882418684427,0.266000713461613,FALSE
+"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.50555,-1.24,0.233,857,0.741,"tilmicosin, dirithromycin, valnemulin, tedizolid, azalomycin.b",0.632644078973981,0.130181792020672,FALSE
+"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.39058,-0.98,0.476,1268,0.829,"novobiocin, lomefloxacin",0.322393047279507,0.0814454694497265,FALSE
+"HCC827","Pearson.est","BCL inhibitor",-0.44984,-1.12,0.325,768,0.678,"ABT.737, oridonin, navitoclax, gossypol, TW.37, HA14.1",0.488116639021126,0.168770306132937,FALSE
+"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.49307,-1.2,0.239,865,0.661,"dasatinib, nilotinib, flumatinib, ponatinib, GZD824, bosutinib, tozasertib",0.621602099051862,0.17979854051436,FALSE
+"HCC827","Pearson.est","benzodiazepine receptor agonist",0.2726,0.78,0.705,361,1,"bentazepam, gamma.aminobutyric.acid, CL.218872, ZK.93423, indiplon, temazepam",0.151810883008601,0,FALSE
+"HCC827","Pearson.est","bromodomain inhibitor",-0.61862,-1.56,0.0418,1191,0.903,"PFI.1, I.BET.762, JQ1...., bromosporine",1.37882371822496,0.0443122496864942,FALSE
+"HCC827","Pearson.est","calcium channel blocker",0.33376,0.93,0.484,129,0.912,"carboxyamidotriazole, fendiline, efonidipine.monoethanolate",0.315154638355588,0.0400051616715838,FALSE
+"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.39536,-0.988,0.46,1162,0.837,"navarixin, RS.504393, MK.0812",0.337242168318426,0.07727454200674,FALSE
+"HCC827","Pearson.est","CDK inhibitor",-0.51168,-1.27,0.196,941,0.753,"BMS.387032, indirubin, palbociclib, ribociclib, aminopurvalanol.a, alvocidib, P276.00, AT.7519, abemaciclib, JNJ.7706621, TG.02, kenpaullone, AZD5438, PHA.793887, BMS.265246",0.707743928643524,0.123205023799299,FALSE
+"HCC827","Pearson.est","CHK inhibitor",-0.52056,-1.32,0.171,887,0.708,"SCH.900776, LY2603618, LY2606368, SB.218078, AZD7762",0.767003889607846,0.149966742310231,FALSE
+"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.32063,-0.794,0.707,1125,0.927,"suxibuzone, aspirin, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam",0.150580586203101,0.0329202658555029,FALSE
+"HCC827","Pearson.est","cytochrome P450 inhibitor",0.33357,0.983,0.432,41,0.929,"morin",0.364516253185088,0.0319842860063582,FALSE
+"HCC827","Pearson.est","DNA alkylating agent",-0.55893,-1.37,0.132,1072,0.669,"carboplatin, estramustine, cyclophosphamide, TH.302, melphalan, satraplatin, streptozotocin, cisplatin",0.87942606879415,0.174573882232177,FALSE
+"HCC827","Pearson.est","DNA inhibitor",-0.29015,-0.725,0.795,1072,0.95,"carboplatin, chlorambucil, primaquine, melphalan, valrubicin, busulfan",0.0996328713435297,0.0222763947111523,FALSE
+"HCC827","Pearson.est","DNA methyltransferase inhibitor",0.36584,1.05,0.373,169,0.922,"disulfiram, azacitidine",0.428291168191312,0.0352690789463706,FALSE
+"HCC827","Pearson.est","DNA polymerase inhibitor",-0.4463,-1.11,0.325,1108,0.653,"trifluridine, idoxuridine, menadione",0.488116639021126,0.185086818724926,FALSE
+"HCC827","Pearson.est","DNA synthesis inhibitor",-0.51491,-1.27,0.2,1317,0.753,"CB.10.277, cyclocytidine, cisplatin",0.698970004336019,0.123205023799299,FALSE
+"HCC827","Pearson.est","dopamine receptor antagonist",-0.37007,-0.908,0.562,1351,0.853,"acetophenazine, piperacetazine, UH.232....",0.250263684430939,0.069050968832477,FALSE
+"HCC827","Pearson.est","estrogen receptor agonist",-0.46072,-1.15,0.303,1242,0.639,"estradiol.cypionate, estradiol, PPT",0.518557371497695,0.1944991418416,FALSE
+"HCC827","Pearson.est","estrogen receptor antagonist",-0.21067,-0.526,0.965,783,0.984,"tamoxifen, clomifene, fulvestrant, danazol",0.0154726866562074,0.00700490156865849,FALSE
+"HCC827","Pearson.est","FGFR inhibitor",0.59119,1.68,0.0465,92,1,"erdafitinib, dovitinib, lenvatinib, PD.173074",1.33254704711005,0,FALSE
+"HCC827","Pearson.est","FLT3 inhibitor",-0.38105,-0.926,0.556,984,0.864,"midostaurin, gilteritinib, ENMD.2076, ponatinib, pacritinib, TG.02, tozasertib, KW.2449, lestaurtinib",0.254925208417942,0.0634862575211067,FALSE
+"HCC827","Pearson.est","glucocorticoid receptor agonist",0.37394,1.05,0.358,282,0.922,"hydrocortisone, triamcinolone.acetonide, piretanide, halcinonide, dexamethasone.acetate, desonide, fluticasone.propionate, betamethasone",0.446116973356126,0.0352690789463706,FALSE
+"HCC827","Pearson.est","glutamate receptor antagonist",0.24815,0.687,0.844,122,0.953,"felbamate, kynurenic.acid, CGP.37849",0.073657553374345,0.0209070993616736,FALSE
+"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.56352,-1.39,0.115,1166,0.672,"LY2090314, tideglusib, AZD2858, GSK.3.inhibitor.IX, kenpaullone",0.939302159646388,0.172630726946175,FALSE
+"HCC827","Pearson.est","growth factor receptor inhibitor",-0.6104,-1.54,0.0444,1251,0.763,"GSK1838705A, AZD3463, lestaurtinib",1.35261702988538,0.11747546204512,FALSE
+"HCC827","Pearson.est","HCV inhibitor",0.50416,1.42,0.116,721,0.481,"PSI.7976, daclatasvir, embelin, narlaprevir, Ro.9187, mericitabine",0.935542010773082,0.317854923626168,FALSE
+"HCC827","Pearson.est","HDAC inhibitor",-0.62836,-1.57,0.0445,1101,1,"PCI.24781, SB.939, panobinostat, entinostat, M.344, belinostat, mocetinostat, RG2833, romidepsin, trichostatin.a, resminostat, R306465, dacinostat, JNJ.26481585, givinostat, AR.42",1.35163998901907,0,FALSE
+"HCC827","Pearson.est","histamine receptor antagonist",-0.34893,-0.867,0.632,1070,0.91,"ICI.162846, cimetidine, lafutidine, famotidine, terfenadine, tiotidine, BF2.649",0.199282921717615,0.0409586076789064,FALSE
+"HCC827","Pearson.est","HMGCR inhibitor",-0.32705,-0.803,0.726,1058,0.935,"simvastatin, pitavastatin",0.139063379299906,0.0291883891274822,FALSE
+"HCC827","Pearson.est","HSP inhibitor",-0.48128,-1.19,0.257,1016,0.657,"tanespimycin, SNX.5422, NVP.AUY922, BIIB021, ganetespib, VER.49009, XL888",0.590066876668705,0.182434630440219,FALSE
+"HCC827","Pearson.est","JAK inhibitor",-0.65375,-1.65,0.029,1126,1,"PRT062070, AZ960, AT.9283, pacritinib, WHI.P154, TG.02, filgotinib, tozasertib, lestaurtinib",1.53760200210104,0,FALSE
+"HCC827","Pearson.est","KIT inhibitor",-0.18875,-0.458,0.986,1439,0.989,"vatalanib",0.0061230850587888,0.0048037084028206,FALSE
+"HCC827","Pearson.est","MDM inhibitor",-0.38806,-0.953,0.535,944,0.834,"idasanutlin, nutlin.3, CGM097, RITA",0.271646217978772,0.0788339493622613,FALSE
+"HCC827","Pearson.est","MEK inhibitor",-0.59097,-1.46,0.079,1081,0.592,"PD.198306, PD.0325901, arctigenin, selumetinib, Ro.4987655, AZD8330, cobimetinib, TAK.733, BIX.02188, trametinib, PD.184352, refametinib, nobiletin",1.10237290870956,0.22767829327708,FALSE
+"HCC827","Pearson.est","MET inhibitor",-0.5097,-1.25,0.207,1189,0.76,"PF.04217903, PHA.665752",0.684029654543082,0.119186407719209,FALSE
+"HCC827","Pearson.est","microtubule inhibitor",-0.22482,-0.563,0.941,750,1,"colchicine, estramustine.phosphate, secnidazole, D.64131, cytochalasin.b",0.0264103765727431,0,FALSE
+"HCC827","Pearson.est","mTOR inhibitor",0.54714,1.52,0.0769,183,0.68,"OSI.027, PF.05212384, PP242, PKI.179, torin.1, AZD2014, WYE.125132, WYE.354, temsirolimus, deforolimus, PF.04691502, ku.0063794, AZD8055, SB.2343",1.11407366019857,0.167491087293764,FALSE
+"HCC827","Pearson.est","NFkB pathway inhibitor",-0.26566,-0.679,0.853,916,0.968,"BAY.11.7085, bortezomib, curcumin, BAY.11.7082, parthenolide, Ro.106.9920, betulinic.acid",0.069050968832477,0.0141246426916063,FALSE
+"HCC827","Pearson.est","opioid receptor agonist",-0.37453,-0.92,0.557,1002,0.852,"BW.180C, trimebutine, salvinorin.a",0.254144804826271,0.0695604052332999,FALSE
+"HCC827","Pearson.est","p38 MAPK inhibitor",-0.46645,-1.16,0.286,996,0.669,"skepinone.l, SB.239063, VX.702, CMPD.1",0.543633966870957,0.174573882232177,FALSE
+"HCC827","Pearson.est","PARP inhibitor",-0.61997,-1.53,0.0689,1331,0.542,"olaparib, talazoparib",1.16178077809237,0.266000713461613,FALSE
+"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.21553,-0.539,0.971,1361,1,"SU014813, CP.673451, vatalanib",0.0127807700919951,0,FALSE
+"HCC827","Pearson.est","phosphatase inhibitor",0.24188,0.676,0.856,23,0.926,"sodium.stibogluconate",0.0675262353228468,0.0333890133180656,FALSE
+"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.32394,-0.819,0.711,1295,0.952,"YM.976, GSK256066",0.148130399270234,0.0213630516155257,FALSE
+"HCC827","Pearson.est","PI3K inhibitor",0.29105,0.824,0.649,183,1,"BGT226, PF.05212384, PKI.179, PI.828, idelalisib, buparlisib, AZD6482, PF.04691502, SB.2343",0.187755303199631,0,FALSE
+"HCC827","Pearson.est","PLK inhibitor",-0.42277,-1.04,0.434,938,0.775,"rigosertib, volasertib, GSK461364, BI.2536",0.362510270487489,0.11069829749369,FALSE
+"HCC827","Pearson.est","potassium channel blocker",-0.31232,-0.768,0.739,1093,0.949,"ibutilide, meglitinide",0.131355561605174,0.0227337875727074,FALSE
+"HCC827","Pearson.est","PPAR receptor agonist",0.57471,1.64,0.0656,59,0.649,"pterostilbene, GW.501516",1.18309616062434,0.187755303199631,FALSE
+"HCC827","Pearson.est","progesterone receptor agonist",0.25843,0.74,0.767,243,0.966,"levonorgestrel, norethindrone",0.115204636051019,0.0150228735845067,FALSE
+"HCC827","Pearson.est","proteasome inhibitor",-0.44057,-1.11,0.354,1155,0.653,"carfilzomib, ixazomib.citrate, ixazomib",0.450996737974212,0.185086818724926,FALSE
+"HCC827","Pearson.est","protein synthesis inhibitor",0.26197,0.741,0.756,29,1,"clofoctol, methacycline",0.121478204498793,0,FALSE
+"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.34378,-0.843,0.693,970,0.931,"PP.121, BMS.599626, NVP.TAE226, rheochrysidin",0.159266765388193,0.0310503190186574,FALSE
+"HCC827","Pearson.est","RAF inhibitor",0.21448,0.618,0.913,1140,0.949,"sorafenib, regorafenib, SB.590885, vemurafenib, RAF265, GDC.0879, dabrafenib, LGX818, PLX.4720, AZ.628, TAK.632, CEP.32496",0.039529222465701,0.0227337875727074,FALSE
+"HCC827","Pearson.est","RET tyrosine kinase inhibitor",0.29287,0.831,0.652,256,1,"apatinib, sorafenib, regorafenib",0.18575240426808,0,FALSE
+"HCC827","Pearson.est","retinoid receptor agonist",0.37372,1.01,0.424,182,0.941,"fenretinide, adapalene, bexarotene",0.372634143407267,0.0264103765727431,FALSE
+"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.49441,-1.22,0.239,1065,0.712,"gemcitabine, triapine, hydroxyurea, fludarabine, clofarabine",0.621602099051862,0.147520006363144,FALSE
+"HCC827","Pearson.est","serotonin receptor agonist",-0.46731,-1.15,0.294,1446,0.639,"aripiprazole",0.531652669587843,0.1944991418416,FALSE
+"HCC827","Pearson.est","serotonin receptor antagonist",-0.48162,-1.17,0.294,1444,0.675,"RS.16566, aripiprazole",0.531652669587843,0.170696227168975,FALSE
+"HCC827","Pearson.est","sodium channel blocker",0.42014,1.18,0.254,163,0.9,"brivaracetam, benzocaine, cibenzoline, benzethonium, mexiletine",0.595166283380062,0.0457574905606751,FALSE
+"HCC827","Pearson.est","src inhibitor",-0.47998,-1.21,0.245,1028,0.669,"KX2.391, PP.1, bosutinib, PP.2",0.610833915635468,0.174573882232177,FALSE
+"HCC827","Pearson.est","sterol demethylase inhibitor",0.39016,1.12,0.271,66,0.94,"chlormidazole",0.567030709125594,0.0268721464003014,FALSE
+"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.29199,-0.726,0.795,1355,0.968,"D.4476",0.0996328713435297,0.0141246426916063,FALSE
+"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.38363,-0.972,0.494,1102,0.821,"raltitrexed, trifluridine",0.306273051076353,0.0856568428805592,FALSE
+"HCC827","Pearson.est","topoisomerase inhibitor",-0.50293,-1.23,0.219,978,0.724,"etoposide, teniposide, rubitecan, irinotecan, exatecan.mesylate, voreloxin, camptothecin, daunorubicin, TAS.103, valrubicin, amonafide, genz.644282, beta.lapachone, licochalcone.a",0.659555885159882,0.140261433802853,FALSE
+"HCC827","Pearson.est","tubulin polymerization inhibitor",-0.21626,-0.537,0.954,1021,0.996,"paclitaxel, KX2.391, epothilone.b, combretastatin.A.4, docetaxel, fosbretabulin, epothilone.d",0.0204516252959049,0.00174066157630127,FALSE
+"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.30577,-0.747,0.775,1214,0.959,"AMG.208, NVP.TAE226, rheochrysidin, vandetanib, tyrphostin.AG.99, UNC2250",0.11069829749369,0.0181813928293364,FALSE
+"HCC827","Pearson.est","VEGFR inhibitor",0.19972,0.57,0.962,92,0.949,"dovitinib, linifanib, lenvatinib, pazopanib, PD.173074",0.0168249279621871,0.0227337875727074,FALSE
+"HCC827","Pearson.est","vitamin D receptor agonist",-0.41479,-1.03,0.421,825,0.771,"doxercalciferol, ercalcitriol, calcitriol, alfacalcidol, tacalcitol",0.375717904164332,0.112945621949043,FALSE
+"CALU3","Pearson.est","EGFR inhibitor",-0.14573,-0.378,1,1143,0.999,"osimertinib, vandetanib, AEE788, TAK.285, brigatinib, PD.153035, BMS.599626",0,0.000434511774017692,FALSE
+"CALU3","Pearson.est","Abl kinase inhibitor",-0.68891,-1.76,0.0214,1117,0.337,"imatinib, bafetinib, KW.2449, tozasertib, flumatinib, metatinib, ponatinib, dasatinib, GZD824",1.66958622665081,0.472370099128661,FALSE
+"CALU3","Pearson.est","acetylcholine receptor agonist",0.47265,1.22,0.228,287,0.589,"pilocarpine, nefiracetam, oxiracetam",0.642065152999546,0.229884705212898,FALSE
+"CALU3","Pearson.est","acetylcholine receptor antagonist",0.3678,0.971,0.477,48,0.698,"diphemanil",0.321481620959886,0.156144577376839,FALSE
+"CALU3","Pearson.est","adenosine receptor antagonist",0.23774,0.615,0.898,87,0.935,"SCH.58261",0.0467236633326956,0.0291883891274822,FALSE
+"CALU3","Pearson.est","adrenergic receptor agonist",-0.35046,-0.898,0.572,1176,0.748,"isoxsuprine, clenbuterol, A61603, terbutaline, buphenine, metaraminol",0.242603971206976,0.126098402135539,FALSE
+"CALU3","Pearson.est","adrenergic receptor antagonist",0.30278,0.786,0.664,215,0.875,"prazosin, oxprenolol, RS.17053, atenolol......",0.177831920631982,0.0579919469776868,FALSE
+"CALU3","Pearson.est","AKT inhibitor",0.29058,0.79,0.713,306,0.906,"GSK2110183, ONC201, GDC.0068",0.146910470148134,0.0428718023231869,FALSE
+"CALU3","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.51178,-1.3,0.163,1257,0.543,"AP26113, brigatinib, CEP.37440, DMH1",0.787812395596042,0.265200170411153,FALSE
+"CALU3","Pearson.est","androgen receptor antagonist",0.56923,1.52,0.101,289,0.426,"nilutamide, enzalutamide, bicalutamide",0.995678626217357,0.370590400897281,FALSE
+"CALU3","Pearson.est","antioxidant",-0.5742,-1.48,0.0881,828,0.535,"taurine, trolox, chlorogenic.acid, benfotiamine, rutin, mesna",1.05502409158795,0.271646217978772,FALSE
+"CALU3","Pearson.est","AP inhibitor",-0.20917,-0.528,0.969,1214,1,"LCL.161",0.0136762229492347,0,FALSE
+"CALU3","Pearson.est","ATPase inhibitor",0.52688,1.41,0.108,65,0.423,"k.strophanthidin, rabeprazole, digitoxin",0.96657624451305,0.373659632624958,FALSE
+"CALU3","Pearson.est","Aurora kinase inhibitor",-0.39399,-1.02,0.425,889,0.62,"MLN.8054, aurora.a.inhibitor.i, CYC116, PF.03814735, barasertib, ZM.447439, AT.9283, ENMD.2076, SNS.314, TAK.901, KW.2449, tozasertib, hesperadin, alisertib",0.371611069949688,0.207608310501746,FALSE
+"CALU3","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.4274,-1.1,0.345,923,0.581,"valnemulin, josamycin, azalomycin.b, dirithromycin, tedizolid",0.462180904926726,0.235823867609669,FALSE
+"CALU3","Pearson.est","bacterial DNA gyrase inhibitor",0.36674,0.973,0.456,68,0.731,"norfloxacin, finafloxacin",0.341035157335565,0.13608262304214,FALSE
+"CALU3","Pearson.est","BCL inhibitor",-0.54771,-1.41,0.143,1110,0.497,"ABT.737, gossypol, navitoclax",0.844663962534938,0.303643611266668,FALSE
+"CALU3","Pearson.est","Bcr.Abl kinase inhibitor",-0.6912,-1.79,0.0153,1117,0.407,"imatinib, bafetinib, tozasertib, flumatinib, metatinib, ponatinib, dasatinib, GZD824",1.8153085691824,0.39040559077478,FALSE
+"CALU3","Pearson.est","benzodiazepine receptor agonist",0.40884,1.06,0.382,319,0.653,"bentazepam, nefiracetam, gamma.aminobutyric.acid, piperazine, eprinomectin",0.417936637088291,0.185086818724926,FALSE
+"CALU3","Pearson.est","bromodomain inhibitor",-0.46012,-1.16,0.301,1156,0.56,"bromosporine, PFI.1",0.521433504406157,0.2518119729938,FALSE
+"CALU3","Pearson.est","calcium channel blocker",-0.42031,-1.07,0.361,1289,0.594,"SKF.96365, penfluridol",0.442492798094342,0.226213555018806,FALSE
+"CALU3","Pearson.est","CC chemokine receptor antagonist",-0.46387,-1.18,0.268,1099,0.619,"navarixin, UNBS.5162, MK.0812, RS.504393",0.571865205971211,0.208309350979882,FALSE
+"CALU3","Pearson.est","CDK inhibitor",-0.53651,-1.37,0.133,949,0.504,"PHA.848125, TG.02, alvocidib, R547, kenpaullone, dinaciclib, BMS.265246, P276.00, AT.7519, JNJ.7706621, palbociclib, ribociclib, AZD5438, abemaciclib",0.876148359032914,0.297569463554475,FALSE
+"CALU3","Pearson.est","CHK inhibitor",-0.5801,-1.53,0.0787,910,0.542,"AZD7762, CHIR.124, SCH.900776, LY2606368, SB.218078",1.10402526764094,0.266000713461613,FALSE
+"CALU3","Pearson.est","cyclooxygenase inhibitor",0.27583,0.733,0.767,161,0.856,"pterostilbene, naproxen, aspirin, AM.404",0.115204636051019,0.0675262353228468,FALSE
+"CALU3","Pearson.est","cytochrome P450 inhibitor",-0.43168,-1.1,0.349,1435,0.581,"itraconazole",0.45717457304082,0.235823867609669,FALSE
+"CALU3","Pearson.est","DNA alkylating agent",-0.30849,-0.791,0.702,1081,0.891,"streptozotocin, TH.302, cisplatin, dianhydrogalactitol, estramustine, carmustine",0.153662887870195,0.0501222959631252,FALSE
+"CALU3","Pearson.est","DNA inhibitor",0.297,0.799,0.68,421,0.931,"mechlorethamine, tirapazamine, carboplatin, metronidazole, teroxirone, nithiamide, bendamustine, busulfan, melphalan, nimorazole",0.167491087293764,0.0310503190186574,FALSE
+"CALU3","Pearson.est","DNA methyltransferase inhibitor",-0.49186,-1.24,0.22,887,0.591,"RG108, fdcyd, azacitidine, SGI.1027, decitabine",0.657577319177794,0.228412519118745,FALSE
+"CALU3","Pearson.est","DNA polymerase inhibitor",0.31569,0.834,0.654,303,0.909,"famciclovir, cidofovir, cephalomannine",0.184422251675733,0.0414361167780325,FALSE
+"CALU3","Pearson.est","DNA synthesis inhibitor",0.19162,0.507,0.976,330,0.977,"artemisinin, artesunate, altretamine, nelarabine",0.0105501823333082,0.0101054362812269,FALSE
+"CALU3","Pearson.est","dopamine receptor antagonist",0.55479,1.49,0.102,119,0.361,"remoxipride, thioproperazine, raclopride, oxiperomide",0.991399828238082,0.442492798094342,FALSE
+"CALU3","Pearson.est","estrogen receptor agonist",0.4407,1.15,0.277,189,0.576,"levonorgestrel, erteberel, ethinyl.estradiol",0.557520230935551,0.239577516576788,FALSE
+"CALU3","Pearson.est","estrogen receptor antagonist",-0.37184,-0.937,0.523,1140,0.721,"fulvestrant, tamoxifen, danazol",0.281498311132726,0.142064735280571,FALSE
+"CALU3","Pearson.est","FGFR inhibitor",-0.42017,-1.08,0.354,1366,0.595,"nintedanib, MK.2461",0.450996737974212,0.22548303427145,FALSE
+"CALU3","Pearson.est","FLT3 inhibitor",-0.45221,-1.15,0.301,1202,0.557,"midostaurin, pacritinib, gilteritinib, KW.2449, tozasertib, lestaurtinib, sunitinib, ponatinib",0.521433504406157,0.254144804826271,FALSE
+"CALU3","Pearson.est","glucocorticoid receptor agonist",0.58182,1.52,0.0886,366,0.426,"hydrocortisone, prednisolone, desonide, ciclesonide, methylprednisolone, dexamethasone.acetate, triamcinolone.acetonide, halcinonide, fluticasone.propionate, piretanide, fludroxycortide, triamcinolone, difluprednate, betamethasone, deflazacort",1.05256627811295,0.370590400897281,FALSE
+"CALU3","Pearson.est","glutamate receptor antagonist",0.28896,0.751,0.74,412,0.897,"tiletamine, latrepirdine, MTPG, CGP.37849, kynurenic.acid, ACDPP, IEM1754",0.130768280269024,0.0472075569559079,FALSE
+"CALU3","Pearson.est","glycogen synthase kinase inhibitor",-0.46507,-1.17,0.274,935,0.587,"CHIR.98014, AZD2858, kenpaullone, tideglusib, GSK.3.inhibitor.IX, LY2090314",0.562249437179612,0.231361898752386,FALSE
+"CALU3","Pearson.est","growth factor receptor inhibitor",-0.47615,-1.23,0.242,949,0.581,"PHA.848125, AZD3463, GSK1838705A, lestaurtinib",0.616184634019569,0.235823867609669,FALSE
+"CALU3","Pearson.est","HCV inhibitor",0.44455,1.17,0.277,7,0.627,"PSI.7976",0.557520230935551,0.202732459169284,FALSE
+"CALU3","Pearson.est","HDAC inhibitor",-0.456,-1.16,0.3,1123,0.56,"givinostat, PCI.24781, belinostat, trichostatin.a, entinostat, resminostat, dacinostat, JNJ.26481585, AR.42, M.344, R306465, RG2833",0.522878745280338,0.2518119729938,FALSE
+"CALU3","Pearson.est","histamine receptor antagonist",0.24511,0.654,0.848,206,0.927,"ranitidine, epinastine, famotidine, terfenadine",0.0716041477432862,0.0329202658555029,FALSE
+"CALU3","Pearson.est","HMGCR inhibitor",0.42545,1.16,0.282,22,0.6,"fluvastatin",0.549750891680639,0.221848749616356,FALSE
+"CALU3","Pearson.est","HSP inhibitor",-0.52902,-1.35,0.16,1059,0.508,"alvespimycin, tanespimycin, SNX.2112, XL888, SNX.5422, ganetespib, VER.49009, NVP.AUY922",0.795880017344075,0.294136287716081,FALSE
+"CALU3","Pearson.est","JAK inhibitor",-0.29549,-0.779,0.726,967,0.849,"TG.101209, TG.02, AZ960, AT.9283, PRT062070, baricitinib, pacritinib, tozasertib, lestaurtinib",0.139063379299906,0.0710923097560473,FALSE
+"CALU3","Pearson.est","KIT inhibitor",-0.60997,-1.56,0.0696,1117,0.653,"imatinib, telatinib, midostaurin, motesanib, masitinib, pazopanib, vatalanib, sunitinib, dasatinib, KI.8751",1.15739076038944,0.185086818724926,FALSE
+"CALU3","Pearson.est","MDM inhibitor",0.70735,1.84,0.0141,428,0.257,"idasanutlin, RITA, nutlin.3, serdemetan, CGM097, AMG.232",1.85078088734462,0.590066876668705,FALSE
+"CALU3","Pearson.est","MEK inhibitor",-0.47941,-1.22,0.23,989,0.572,"refametinib, PD.184352, MEK162, BIX.02188, selumetinib, AS.703026, TAK.733, AZD8330, nobiletin, arctigenin, trametinib, cobimetinib",0.638272163982407,0.242603971206976,FALSE
+"CALU3","Pearson.est","MET inhibitor",-0.80761,-2.05,0,1371,0.0949,"PHA.665752, LY2801653, INC.280, NVP.BVU972",Inf,1.02273378757271,TRUE
+"CALU3","Pearson.est","microtubule inhibitor",-0.18774,-0.478,0.987,1356,1,"cytochalasin.b",0.00568284733036327,0,FALSE
+"CALU3","Pearson.est","mTOR inhibitor",-0.29971,-0.763,0.737,1002,0.853,"WYE.354, AZD2014, MLN0128, deforolimus, GSK2126458, GDC.0980, NVP.BEZ235, torin.2, everolimus, temsirolimus",0.132532512140949,0.069050968832477,FALSE
+"CALU3","Pearson.est","NFkB pathway inhibitor",-0.40412,-1.03,0.404,1346,0.622,"betulinic.acid, bortezomib, Ro.106.9920",0.393618634889395,0.206209615309181,FALSE
+"CALU3","Pearson.est","opioid receptor agonist",-0.59869,-1.49,0.0909,1183,0.575,"trimebutine, cebranopadol",1.04143611677803,0.24033215531037,FALSE
+"CALU3","Pearson.est","p38 MAPK inhibitor",0.39146,1.03,0.413,178,0.668,"talmapimod, SB.242235",0.384049948343599,0.175223537524454,FALSE
+"CALU3","Pearson.est","PARP inhibitor",-0.29158,-0.738,0.785,1090,0.869,"olaparib, PJ.34, talazoparib",0.105130343254747,0.0609802235513335,FALSE
+"CALU3","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52178,-1.34,0.166,1117,0.496,"imatinib, telatinib, motesanib, masitinib, trapidil, CP.673451, nintedanib, pazopanib, vatalanib, sunitinib, ponatinib, dasatinib, KI.8751",0.779891911959945,0.304518323509803,FALSE
+"CALU3","Pearson.est","phosphatase inhibitor",-0.22184,-0.568,0.955,319,0.999,"GSK2830371, bis.maltolato.oxovanadium.IV., mycophenolic.acid, mycophenolate.mofetil, CID.5458317, sodium.stibogluconate, AS.1949490, menadione, alexidine, BVT.948",0.0199966284162537,0.000434511774017692,FALSE
+"CALU3","Pearson.est","phosphodiesterase inhibitor",-0.30659,-0.781,0.731,1160,0.866,"trequinsin, YM.976, EMD.53998",0.13608262304214,0.0624821079826534,FALSE
+"CALU3","Pearson.est","PI3K inhibitor",-0.27093,-0.683,0.827,1037,0.925,"buparlisib, ZSTK.474, CH5132799, GSK2126458, GDC.0980, TG.100713, TG100.115, NVP.BEZ235, CUDC.907, PIK.75",0.0824944904474534,0.0338582672609674,FALSE
+"CALU3","Pearson.est","PLK inhibitor",0.29422,0.748,0.769,231,0.867,"HMN.214, NMS.1286937",0.114073660198569,0.0619809025237897,FALSE
+"CALU3","Pearson.est","potassium channel blocker",-0.46022,-1.17,0.296,1207,0.587,"dofetilide, mepivacaine",0.528708288941061,0.231361898752386,FALSE
+"CALU3","Pearson.est","PPAR receptor agonist",0.58746,1.63,0.0439,9,0.392,"pterostilbene",1.35753547975788,0.406713932979543,FALSE
+"CALU3","Pearson.est","progesterone receptor agonist",0.6618,1.75,0.0312,163,0.284,"norethindrone, levonorgestrel, norgestrel, dienogest, norethindrone.acetate",1.50584540598156,0.546681659952962,FALSE
+"CALU3","Pearson.est","proteasome inhibitor",-0.56836,-1.41,0.135,1229,0.497,"ixazomib, carfilzomib, bortezomib",0.869666231504994,0.303643611266668,FALSE
+"CALU3","Pearson.est","protein synthesis inhibitor",0.50482,1.29,0.167,144,0.511,"azomycin..2.nitroimidazole., chloramphenicol.palmitate, cycloheximide, clofoctol, tedizolid.phosphate, bruceantin",0.777283528852417,0.291579099865287,FALSE
+"CALU3","Pearson.est","protein tyrosine kinase inhibitor",-0.40837,-1.04,0.402,1423,0.624,"BMS.599626",0.39577394691553,0.204815410317576,FALSE
+"CALU3","Pearson.est","RAF inhibitor",-0.60857,-1.55,0.0486,948,0.572,"PLX.4720, sorafenib, vemurafenib, GDC.0879, SB.590885, TAK.632, RAF265, AZ.628, LGX818, dabrafenib",1.31336373073771,0.242603971206976,FALSE
+"CALU3","Pearson.est","RET tyrosine kinase inhibitor",-0.54594,-1.37,0.134,939,0.504,"cabozantinib, sorafenib, vandetanib, sunitinib",0.872895201635192,0.297569463554475,FALSE
+"CALU3","Pearson.est","retinoid receptor agonist",-0.25319,-0.651,0.881,1122,0.942,"AM.580, fenretinide, adarotene",0.0550240915879521,0.0259490972071227,FALSE
+"CALU3","Pearson.est","ribonucleotide reductase inhibitor",-0.55843,-1.42,0.125,1147,0.564,"hydroxyurea, triapine, fludarabine, clofarabine",0.903089986991944,0.248720896016658,FALSE
+"CALU3","Pearson.est","serotonin receptor agonist",0.77752,2.08,0.00691,1,0.0826,"aripiprazole",2.1605219526258,1.08301995267962,TRUE
+"CALU3","Pearson.est","serotonin receptor antagonist",0.42718,1.11,0.31,1,0.605,"aripiprazole",0.508638306165727,0.218244625347531,FALSE
+"CALU3","Pearson.est","sodium channel blocker",-0.30563,-0.782,0.717,981,0.885,"benzocaine, butamben, mexiletine, ajmaline, oxcarbazepine, quinidine, lappaconite, mepivacaine",0.1444808443322,0.0530567293021746,FALSE
+"CALU3","Pearson.est","src inhibitor",-0.60455,-1.57,0.0661,1205,0.779,"masitinib, saracatinib, PP.1, dasatinib, TG.100572",1.17979854051436,0.108462542327436,FALSE
+"CALU3","Pearson.est","sterol demethylase inhibitor",0.49854,1.36,0.131,321,0.451,"terconazole, lanoconazole, ketoconazole",0.882728704344236,0.345823458122039,FALSE
+"CALU3","Pearson.est","TGF beta receptor inhibitor",-0.39864,-1,0.45,933,0.636,"LY2109761, SB.431542, repsox, D.4476",0.346787486224656,0.196542884351586,FALSE
+"CALU3","Pearson.est","thymidylate synthase inhibitor",-0.43413,-1.11,0.339,1184,0.604,"raltitrexed, doxifluridine, trifluridine",0.469800301796918,0.218963061378868,FALSE
+"CALU3","Pearson.est","topoisomerase inhibitor",-0.55942,-1.45,0.11,942,0.551,"nemorubicin, camptothecin, genz.644282, voreloxin, amonafide, exatecan.mesylate, fleroxacin, doxorubicin, licochalcone.a, topotecan, valrubicin, etoposide.phosphate, rubitecan, teniposide, SN.38, etoposide, daunorubicin, irinotecan",0.958607314841775,0.258848401148215,FALSE
+"CALU3","Pearson.est","tubulin polymerization inhibitor",0.57638,1.49,0.111,219,0.361,"nocodazole, dolastatin.10, vinorelbine, taltobulin, BNC105, CYT.997, mebendazole, indibulin, KX2.391, ABT.751, vincristine, verubulin, vinblastine",0.954677021213343,0.442492798094342,FALSE
+"CALU3","Pearson.est","tyrosine kinase inhibitor",-0.33975,-0.855,0.627,939,0.804,"cabozantinib, mubritinib, sorafenib, tyrphostin.AG.99, bafetinib, tivantinib, vandetanib, hypericin, sunitinib, dasatinib, BMS.599626",0.202732459169284,0.0947439512515487,FALSE
+"CALU3","Pearson.est","VEGFR inhibitor",-0.50334,-1.26,0.198,1366,0.584,"nintedanib, pazopanib, tivozanib, vatalanib, sunitinib, KI.8751, MK.2461, golvatinib, TG.100572, foretinib",0.703334809738469,0.233587152887601,FALSE
+"CALU3","Pearson.est","vitamin D receptor agonist",-0.34669,-0.904,0.548,790,0.756,"doxercalciferol, ercalcitriol, alfacalcidol, calcitriol, tacalcitol",0.261219441515631,0.121478204498793,FALSE
+"H2009","Pearson.est","EGFR inhibitor",0.17971,0.505,0.992,108,0.983,"WZ.3146, BIBX.1382, CUDC.101, WZ.4002, CNX.2006",0.00348832784582135,0.00744648216786438,FALSE
+"H2009","Pearson.est","Abl kinase inhibitor",-0.53111,-1.28,0.188,874,0.724,"metatinib, KW.2449, tozasertib, imatinib, nilotinib, flumatinib, bosutinib, ponatinib",0.72584215073632,0.140261433802853,FALSE
+"H2009","Pearson.est","acetylcholine receptor agonist",-0.46759,-1.11,0.329,1141,0.693,"pilocarpine, nicotine",0.482804102050026,0.159266765388193,FALSE
+"H2009","Pearson.est","acetylcholine receptor antagonist",-0.58871,-1.42,0.0966,911,0.601,"iododexetimide, darifenacin, hyoscyamine, dicycloverine, methscopolamine",1.01502287358451,0.22112552799726,FALSE
+"H2009","Pearson.est","adenosine receptor antagonist",-0.52844,-1.28,0.156,1099,0.724,"istradefylline, sulmazole, PSB.1115",0.806875401645538,0.140261433802853,FALSE
+"H2009","Pearson.est","adrenergic receptor agonist",-0.48395,-1.15,0.309,956,0.651,"ritodrine, metaraminol, isoxsuprine, epinephrine, buphenine, A61603, terbutaline, isoetharine, clenbuterol",0.510041520575165,0.186419011431808,FALSE
+"H2009","Pearson.est","adrenergic receptor antagonist",-0.41894,-1.03,0.448,1003,0.724,"pindolol, levobunolol, idazoxan, metoprolol, atipamezole, atenolol...., dronedarone",0.348721986001856,0.140261433802853,FALSE
+"H2009","Pearson.est","AKT inhibitor",-0.19235,-0.458,0.984,1107,1,"uprosertib, palomid.529",0.00700490156865849,0,FALSE
+"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25599,-0.63,0.916,1104,0.979,"GW.788388, CEP.37440, DMH1",0.0381045263321496,0.00921730819686218,FALSE
+"H2009","Pearson.est","androgen receptor antagonist",-0.41524,-1.02,0.457,1108,0.725,"cyproterone.acetate, enzalutamide, flutamide",0.34008379993015,0.139661993429006,FALSE
+"H2009","Pearson.est","antioxidant",-0.41149,-0.985,0.478,1122,0.758,"benfotiamine, taurine",0.320572103387881,0.120330794367946,FALSE
+"H2009","Pearson.est","AP inhibitor",0.34323,0.963,0.423,313,0.741,"birinapant, tanshinone.i, embelin, idronoxil",0.373659632624958,0.130181792020672,FALSE
+"H2009","Pearson.est","ATPase inhibitor",0.40152,1.1,0.317,11,0.746,"k.strophanthidin, rabeprazole",0.498940737782249,0.127261172527331,FALSE
+"H2009","Pearson.est","Aurora kinase inhibitor",-0.19929,-0.475,0.99,850,1,"hesperadin, ZM.447439, KW.2449, tozasertib, MK.8745, SNS.314, CYC116, ENMD.2076, alisertib",0.00436480540245009,0,FALSE
+"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.62109,-1.45,0.0812,933,0.639,"tilmicosin, josamycin, azalomycin.b, radezolid, tedizolid, dirithromycin",1.09044397075882,0.1944991418416,FALSE
+"H2009","Pearson.est","bacterial DNA gyrase inhibitor",0.43069,1.19,0.253,59,0.648,"norfloxacin, finafloxacin, lomefloxacin",0.596879478824182,0.188424994129407,FALSE
+"H2009","Pearson.est","BCL inhibitor",-0.34703,-0.854,0.675,1194,0.87,"ABT.737, navitoclax",0.170696227168975,0.0604807473813815,FALSE
+"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.53399,-1.27,0.194,874,0.71,"metatinib, tozasertib, imatinib, nilotinib, flumatinib, bosutinib, ponatinib",0.712198270069774,0.148741651280925,FALSE
+"H2009","Pearson.est","benzodiazepine receptor agonist",0.28012,0.784,0.732,182,0.901,"eprinomectin, bentazepam, ivermectin, gamma.aminobutyric.acid",0.135488918941608,0.045275209020937,FALSE
+"H2009","Pearson.est","bromodomain inhibitor",-0.7448,-1.83,0.00794,1074,0.277,"OTX015, PFI.1, I.BET.762, I.BET151, JQ1...., bromosporine",2.1001794975729,0.557520230935551,FALSE
+"H2009","Pearson.est","calcium channel blocker",-0.26506,-0.638,0.905,1117,0.988,"tetrandrine, efonidipine.monoethanolate, SKF.96365",0.0433514207947967,0.00524305541237188,FALSE
+"H2009","Pearson.est","CC chemokine receptor antagonist",-0.50911,-1.23,0.222,780,0.588,"UNBS.5162, SB.225002, PF.04136309, MK.0812, RS.504393",0.653647025549361,0.230622673923862,FALSE
+"H2009","Pearson.est","CDK inhibitor",-0.50993,-1.24,0.208,971,0.646,"aminopurvalanol.a, JNJ.7706621, alvocidib, kenpaullone, AZD5438, indisulam, BMS.387032, palbociclib, PHA.793887, dinaciclib, ribociclib, TG.02, P276.00, AT.7519, abemaciclib",0.681936665037238,0.189767482004916,FALSE
+"H2009","Pearson.est","CHK inhibitor",-0.49495,-1.18,0.261,838,0.63,"PF.477736, LY2606368, AZD7762, LY2603618, SB.218078",0.583359492661719,0.200659450546418,FALSE
+"H2009","Pearson.est","cyclooxygenase inhibitor",-0.23569,-0.575,0.935,836,1,"piroxicam, acetylsalicylsalicylic.acid, phenazone, naproxen, phenylbutazone, ketoprofen, sulfasalazine, tryptanthrin, FR.122047, ramifenazone, indoprofen, suxibuzone",0.0291883891274822,0,FALSE
+"H2009","Pearson.est","cytochrome P450 inhibitor",-0.51104,-1.23,0.208,1013,0.588,"clotrimazole, morin, PF.4981517, itraconazole",0.681936665037238,0.230622673923862,FALSE
+"H2009","Pearson.est","DNA alkylating agent",-0.5237,-1.26,0.215,1144,0.698,"ifosfamide, streptozotocin, temozolomide, mitomycin.c, cisplatin, carmustine, estramustine",0.667561540084395,0.156144577376839,FALSE
+"H2009","Pearson.est","DNA inhibitor",-0.31788,-0.774,0.75,1089,0.908,"bendamustine, busulfan, carmustine, pibenzimol, primaquine",0.1249387366083,0.0419141514789149,FALSE
+"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.52123,-1.24,0.237,944,0.646,"SGI.1027, fdcyd, decitabine, azacitidine",0.625251653989896,0.189767482004916,FALSE
+"H2009","Pearson.est","DNA polymerase inhibitor",-0.30872,-0.751,0.784,1152,0.924,"idoxuridine, menadione, trifluridine",0.105683937315562,0.0343280287798933,FALSE
+"H2009","Pearson.est","DNA synthesis inhibitor",-0.29743,-0.715,0.815,1224,0.955,"mitomycin.c, cisplatin, capecitabine",0.0888423912600234,0.0199966284162537,FALSE
+"H2009","Pearson.est","dopamine receptor antagonist",-0.26798,-0.65,0.896,1088,0.994,"amisulpride, paliperidone, ziprasidone, mesoridazine, piperacetazine, lurasidone",0.0476919903378748,0.00261361560268669,FALSE
+"H2009","Pearson.est","estrogen receptor agonist",-0.3681,-0.88,0.616,1017,0.844,"estradiol.cypionate, erteberel, PPT, estradiol",0.210419287835575,0.073657553374345,FALSE
+"H2009","Pearson.est","estrogen receptor antagonist",-0.54696,-1.31,0.168,1048,0.781,"danazol, clomifene, tamoxifen",0.774690718274137,0.1073489661227,FALSE
+"H2009","Pearson.est","FGFR inhibitor",-0.51013,-1.2,0.256,1091,0.634,"regorafenib, lucitanib, nintedanib, MK.2461",0.59176003468815,0.197910742118267,FALSE
+"H2009","Pearson.est","FLT3 inhibitor",-0.40894,-0.998,0.468,847,0.75,"sorafenib, midostaurin, quizartinib, lestaurtinib, KW.2449, tozasertib, ENMD.2076, pacritinib, tandutinib, ponatinib, TG.02, gilteritinib",0.329754146925876,0.1249387366083,FALSE
+"H2009","Pearson.est","glucocorticoid receptor agonist",0.24954,0.697,0.834,82,0.931,"hydrocortisone, triamcinolone.acetonide, ciclesonide",0.0788339493622613,0.0310503190186574,FALSE
+"H2009","Pearson.est","glutamate receptor antagonist",-0.18465,-0.447,0.99,863,0.992,"IEM1754, kynurenic.acid, LY456236, ACDPP, diazooxonorleucine, JNJ.16259685",0.00436480540245009,0.00348832784582135,FALSE
+"H2009","Pearson.est","glycogen synthase kinase inhibitor",0.2606,0.717,0.808,1073,0.958,"TWS.119, tideglusib, CHIR.98014, indirubin, AZD2858, GSK.3.inhibitor.IX, LY2090314, CHIR.99021, kenpaullone",0.0925886392254138,0.0186344909214556,FALSE
+"H2009","Pearson.est","growth factor receptor inhibitor",-0.4938,-1.18,0.27,814,0.63,"AZD3463, PHA.848125, GSK1904529A, lestaurtinib, GSK1838705A",0.568636235841013,0.200659450546418,FALSE
+"H2009","Pearson.est","HCV inhibitor",-0.54411,-1.31,0.168,1387,0.781,"narlaprevir, mericitabine",0.774690718274137,0.1073489661227,FALSE
+"H2009","Pearson.est","HDAC inhibitor",-0.34412,-0.834,0.661,891,0.868,"RGFP966, AR.42, trichostatin.a, panobinostat, SB.939, entinostat, dacinostat, belinostat, pyroxamide, resminostat, vorinostat, R306465, M.344, RG2833",0.17979854051436,0.0614802748235081,FALSE
+"H2009","Pearson.est","histamine receptor antagonist",-0.21798,-0.522,0.976,1065,1,"ICI.162846, lafutidine, BF2.649, cimetidine, tiotidine",0.0105501823333082,0,FALSE
+"H2009","Pearson.est","HMGCR inhibitor",0.59536,1.64,0.0312,370,0.324,"fluvastatin, pitavastatin, simvastatin, atorvastatin, mevastatin",1.50584540598156,0.489454989793388,FALSE
+"H2009","Pearson.est","HSP inhibitor",-0.58867,-1.42,0.0901,1026,0.601,"VER.49009, ganetespib, alvespimycin, tanespimycin, KW.2478, SNX.5422, NVP.AUY922, XL888",1.04527520902094,0.22112552799726,FALSE
+"H2009","Pearson.est","JAK inhibitor",-0.52139,-1.28,0.195,893,0.724,"PRT062070, LY2784544, lestaurtinib, tozasertib, WHI.P154, TG.101209, AZD1480, AZ960, CEP.33779, atiprimod, pacritinib, baricitinib, TG.02",0.709965388637482,0.140261433802853,FALSE
+"H2009","Pearson.est","KIT inhibitor",-0.44808,-1.08,0.373,737,0.696,"telatinib, sunitinib, masitinib, sorafenib, midostaurin, vatalanib, imatinib, regorafenib, motesanib, OSI.930, KI.8751, tandutinib, pazopanib",0.428291168191312,0.157390760389438,FALSE
+"H2009","Pearson.est","MDM inhibitor",0.8192,2.29,0,206,0.0248,"idasanutlin, RITA, serdemetan, AMG.232, CGM097",Inf,1.60554831917378,TRUE
+"H2009","Pearson.est","MEK inhibitor",-0.39213,-0.942,0.548,1083,0.785,"AS.703026, selumetinib, BIX.02188, nobiletin, trametinib, arctigenin, cobimetinib",0.261219441515631,0.105130343254747,FALSE
+"H2009","Pearson.est","MET inhibitor",-0.70637,-1.68,0.0109,1053,0.556,"PHA.665752, LY2801653, AMG458, INC.280, NVP.BVU972",1.96257350205938,0.254925208417942,FALSE
+"H2009","Pearson.est","microtubule inhibitor",-0.44527,-1.06,0.39,1114,0.719,"vinflunine, secnidazole, cytochalasin.b, D.64131",0.408935392973501,0.143271109617117,FALSE
+"H2009","Pearson.est","mTOR inhibitor",0.49957,1.42,0.124,104,0.553,"torin.1, SB.2343, ku.0063794, PF.05212384, sirolimus, PKI.179, WAY.600, PP242",0.906578314837765,0.257274868695302,FALSE
+"H2009","Pearson.est","NFkB pathway inhibitor",-0.4349,-1.05,0.402,1314,0.702,"Ro.106.9920, bortezomib, betulinic.acid",0.39577394691553,0.153662887870195,FALSE
+"H2009","Pearson.est","opioid receptor agonist",-0.48813,-1.14,0.308,822,0.649,"cebranopadol, ADL5859, salvinorin.a, trimebutine",0.511449283499556,0.187755303199631,FALSE
+"H2009","Pearson.est","p38 MAPK inhibitor",-0.41268,-0.984,0.484,1086,0.742,"SB.239063, TAK.715",0.315154638355588,0.129596094720973,FALSE
+"H2009","Pearson.est","PARP inhibitor",-0.38725,-0.907,0.601,1057,0.814,"olaparib, talazoparib, PJ.34",0.22112552799726,0.0893755951107988,FALSE
+"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.3926,-0.94,0.531,777,0.772,"sunitinib, masitinib, sorafenib, crenolanib, trapidil, vatalanib, SU014813, imatinib, regorafenib, motesanib, KI.8751, nintedanib, tandutinib, pazopanib, ponatinib, CP.673451",0.274905478918531,0.112382699664264,FALSE
+"H2009","Pearson.est","phosphatase inhibitor",0.3028,0.818,0.683,7,0.971,"bis.maltolato.oxovanadium.IV.",0.165579296318467,0.0127807700919951,FALSE
+"H2009","Pearson.est","phosphodiesterase inhibitor",-0.27883,-0.666,0.873,729,0.995,"zardaverine, cilostamide, YM.976, GSK256066, avanafil, papaverine, EMD.53998, trequinsin",0.0589857562944303,0.00217691925427455,FALSE
+"H2009","Pearson.est","PI3K inhibitor",0.29781,0.816,0.663,128,0.905,"SB.2343, PF.05212384, PKI.179, YM.201636",0.178486471595227,0.0433514207947967,FALSE
+"H2009","Pearson.est","PLK inhibitor",-0.55495,-1.33,0.147,1203,0.846,"rigosertib, GW.843682X, volasertib",0.832682665251824,0.0726296369609765,FALSE
+"H2009","Pearson.est","potassium channel blocker",-0.61882,-1.47,0.0693,967,0.764,"oleoylethanolamide, mepivacaine, dofetilide",1.15926676538819,0.11690664142431,FALSE
+"H2009","Pearson.est","PPAR receptor agonist",0.36909,1.03,0.402,147,0.818,"pterostilbene, clofibrate",0.39577394691553,0.087246696328677,FALSE
+"H2009","Pearson.est","progesterone receptor agonist",0.35305,0.999,0.414,32,0.807,"norethindrone, levonorgestrel",0.382999658879101,0.0931264652779296,FALSE
+"H2009","Pearson.est","proteasome inhibitor",-0.51122,-1.23,0.206,1364,0.588,"carfilzomib, bortezomib",0.686132779630847,0.230622673923862,FALSE
+"H2009","Pearson.est","protein synthesis inhibitor",0.34597,0.978,0.436,177,0.777,"clofoctol, cycloheximide, chloramphenicol.palmitate, methacycline, mercaptopurine, thiostrepton",0.360513510731414,0.109578981199086,FALSE
+"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.44592,-1.08,0.369,1150,0.696,"rheochrysidin, AV.412, BMS.599626",0.43297363384094,0.157390760389438,FALSE
+"H2009","Pearson.est","RAF inhibitor",-0.51813,-1.24,0.202,1060,0.646,"AZ.628, regorafenib, GDC.0879, vemurafenib, TAK.632, dabrafenib, RAF265",0.694648630553376,0.189767482004916,FALSE
+"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.47386,-1.15,0.27,777,0.651,"sunitinib, sorafenib, cabozantinib, apatinib, regorafenib",0.568636235841013,0.186419011431808,FALSE
+"H2009","Pearson.est","retinoid receptor agonist",-0.59974,-1.45,0.0828,1375,0.639,"tamibarotene, adarotene",1.08196966321512,0.1944991418416,FALSE
+"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.4396,-1.05,0.408,1197,0.702,"pentostatin, fludarabine, clofarabine",0.38933983691012,0.153662887870195,FALSE
+"H2009","Pearson.est","serotonin receptor agonist",0.61344,1.74,0.0233,1,0.341,"aripiprazole",1.63264407897398,0.467245621007502,FALSE
+"H2009","Pearson.est","serotonin receptor antagonist",-0.40413,-0.98,0.488,1151,0.733,"SB.216641, paliperidone, ziprasidone, SB.228357, lurasidone, RS.16566",0.311580177997289,0.134896025358872,FALSE
+"H2009","Pearson.est","sodium channel blocker",-0.33001,-0.804,0.712,894,0.898,"ajmaline, oxcarbazepine, mepivacaine, benzethonium, lappaconite, triamterene, quinidine",0.147520006363144,0.0467236633326956,FALSE
+"H2009","Pearson.est","src inhibitor",-0.61802,-1.49,0.0704,1320,0.815,"bosutinib, TG.100572, PP.1",1.15242734085789,0.0888423912600234,FALSE
+"H2009","Pearson.est","sterol demethylase inhibitor",0.47007,1.28,0.189,275,0.576,"terconazole, lanoconazole, ketoconazole, sulconazole",0.723538195826756,0.239577516576788,FALSE
+"H2009","Pearson.est","TGF beta receptor inhibitor",-0.64512,-1.56,0.0332,1332,0.656,"LY2109761, D.4476",1.47886191629596,0.18309616062434,FALSE
+"H2009","Pearson.est","thymidylate synthase inhibitor",-0.69526,-1.66,0.0212,1112,0.436,"raltitrexed, trifluridine, doxifluridine, capecitabine",1.67366413907125,0.360513510731414,FALSE
+"H2009","Pearson.est","topoisomerase inhibitor",0.20006,0.567,0.951,136,1,"epirubicin, beta.lapachone, voreloxin, TAS.103",0.0218194830625861,0,FALSE
+"H2009","Pearson.est","tubulin polymerization inhibitor",-0.32683,-0.784,0.742,1147,0.911,"parbendazole, fosbretabulin, vindesine, docetaxel, albendazole, paclitaxel",0.129596094720973,0.0404816230270017,FALSE
+"H2009","Pearson.est","tyrosine kinase inhibitor",-0.35334,-0.84,0.675,777,0.876,"sunitinib, tyrphostin.A9, CP.724714, sorafenib, AMG.208, cabozantinib, aminopurvalanol.a, apatinib, regorafenib, rheochrysidin, AV.412, hypericin, BMS.599626, tivantinib",0.170696227168975,0.0574958938319193,FALSE
+"H2009","Pearson.est","VEGFR inhibitor",-0.45098,-1.09,0.35,1091,0.714,"regorafenib, lucitanib, motesanib, OSI.930, tivozanib, KI.8751, nintedanib, ENMD.2076, pazopanib, RAF265, TG.100572, MK.2461, golvatinib, foretinib",0.455931955649724,0.146301788223826,FALSE
+"H2009","Pearson.est","vitamin D receptor agonist",0.46093,1.31,0.167,167,0.627,"doxercalciferol, maxacalcitol, paricalcitol",0.777283528852417,0.202732459169284,FALSE
+"HCC4006","Pearson.est","EGFR inhibitor",-0.46484,-1.13,0.311,1123,0.653,"PD.153035, PD.168393, rociletinib, BIBU.1361, pelitinib, WZ.4002, icotinib, BMS.599626, gefitinib, canertinib, tucatinib, CP.724714, osimertinib, erlotinib, OSI.420, XL.647, AEE788, WZ8040",0.507239610973163,0.185086818724926,FALSE
+"HCC4006","Pearson.est","Abl kinase inhibitor",-0.46968,-1.13,0.317,805,0.653,"metatinib, KW.2449, dasatinib, flumatinib, ZM.306416, tozasertib, imatinib, bosutinib",0.498940737782249,0.185086818724926,FALSE
+"HCC4006","Pearson.est","acetylcholine receptor agonist",-0.41193,-0.993,0.484,594,0.837,"tremorine, xanomeline, oxiracetam, nicotine, nefiracetam, pilocarpine",0.315154638355588,0.07727454200674,FALSE
+"HCC4006","Pearson.est","acetylcholine receptor antagonist",-0.39562,-0.944,0.54,680,0.869,"iododexetimide, diphemanil, methscopolamine, dicycloverine, darifenacin",0.267606240177031,0.0609802235513335,FALSE
+"HCC4006","Pearson.est","adenosine receptor antagonist",-0.56551,-1.36,0.113,1249,0.682,"PSB.1115, CGS.15943, sulmazole",0.94692155651658,0.166215625343521,FALSE
+"HCC4006","Pearson.est","adrenergic receptor agonist",0.29239,0.87,0.654,1029,0.914,"norepinephrine, ritodrine, terbutaline, isoxsuprine, A61603, lidamidine, methyldopa, metaraminol, oxymetazoline, buphenine, xylazine, isoetharine, epinephrine, clenbuterol, midodrine",0.184422251675733,0.0390538042661686,FALSE
+"HCC4006","Pearson.est","adrenergic receptor antagonist",-0.47946,-1.15,0.279,1039,0.669,"idazoxan, RS.17053, dronedarone, vincamine, imiloxan, dihydroergocristine, oxprenolol, pindolol",0.554395796726402,0.174573882232177,FALSE
+"HCC4006","Pearson.est","AKT inhibitor",-0.65591,-1.57,0.0306,1393,0.698,"AT7867, palomid.529, AZD5363, CCT128930",1.51427857351842,0.156144577376839,FALSE
+"HCC4006","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.50449,-1.21,0.226,774,0.584,"SB.505124, AP26113, brigatinib, alectinib, DMH1, CEP.37440, GW.788388, AZD3463",0.645891560852599,0.233587152887601,FALSE
+"HCC4006","Pearson.est","androgen receptor antagonist",-0.52111,-1.25,0.193,1009,0.58,"RU.58841, flutamide, nilutamide, bicalutamide",0.714442690992226,0.236572006437063,FALSE
+"HCC4006","Pearson.est","antioxidant",-0.5388,-1.29,0.156,896,0.663,"mesna, chlorogenic.acid, benfotiamine, trolox, taurine",0.806875401645538,0.178486471595227,FALSE
+"HCC4006","Pearson.est","AP inhibitor",0.52741,1.59,0.0571,87,0.156,"birinapant, GDC.0152, idronoxil",1.24336389175415,0.806875401645538,FALSE
+"HCC4006","Pearson.est","ATPase inhibitor",-0.20832,-0.502,0.975,613,0.979,"rabeprazole, evodiamine, thonzonium, digitoxin, blebbistatin...., ouabain, oligomycin.a, omeprazole, digoxin",0.0109953843014632,0.00921730819686218,FALSE
+"HCC4006","Pearson.est","Aurora kinase inhibitor",-0.53814,-1.29,0.16,977,0.663,"barasertib.HQPA, CCT137690, alisertib, AMG900, MK.8745, SNS.314, TAK.901, ENMD.2076, PF.03814735, tozasertib, ZM.447439, danusertib, AT.9283, CYC116, hesperadin, CCT129202",0.795880017344075,0.178486471595227,FALSE
+"HCC4006","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.6141,-1.49,0.0449,1221,0.442,"tedizolid, azalomycin.b, valnemulin, tilmicosin",1.34775365899668,0.354577730650908,FALSE
+"HCC4006","Pearson.est","bacterial DNA gyrase inhibitor",0.58533,1.79,0.0147,141,0.165,"sparfloxacin, sarafloxacin, finafloxacin, lomefloxacin, trovafloxacin",1.83268266525182,0.782516055786094,TRUE
+"HCC4006","Pearson.est","BCL inhibitor",0.33798,1.05,0.394,178,0.798,"navitoclax, ABT.737, HA14.1",0.404503778174426,0.0979971086492706,FALSE
+"HCC4006","Pearson.est","Bcr.Abl kinase inhibitor",-0.48043,-1.16,0.296,1256,0.667,"tozasertib, imatinib, bosutinib",0.528708288941061,0.175874166083451,FALSE
+"HCC4006","Pearson.est","benzodiazepine receptor agonist",-0.2666,-0.628,0.907,1051,0.973,"nefiracetam, eprinomectin, lorazepam",0.0423927129399047,0.0118871597316481,FALSE
+"HCC4006","Pearson.est","bromodomain inhibitor",-0.51963,-1.27,0.186,772,0.582,"I.BET151, bromosporine, OTX015, I.BET.762, JQ1....",0.730487055782084,0.235077015350112,FALSE
+"HCC4006","Pearson.est","calcium channel blocker",-0.45405,-1.07,0.379,1125,0.736,"pranidipine, cinnarazine, mibefradil, tetrandrine",0.421360790031928,0.133122185662501,FALSE
+"HCC4006","Pearson.est","CC chemokine receptor antagonist",-0.43609,-1.05,0.415,874,0.764,"RS.504393, SB.225002, PF.04136309, MK.0812, navarixin",0.381951903287907,0.11690664142431,FALSE
+"HCC4006","Pearson.est","CDK inhibitor",-0.61361,-1.49,0.0526,1052,0.442,"arcyriaflavin.a, BMS.265246, dinaciclib, TG.02, ribociclib, abemaciclib, palbociclib, BMS.387032, AT.7519, indisulam, aminopurvalanol.a, JNJ.7706621, R547, PHA.793887",1.27901425584626,0.354577730650908,FALSE
+"HCC4006","Pearson.est","CHK inhibitor",0.26162,0.789,0.655,1071,0.908,"CHIR.124, SCH.900776, LY2606368, SB.218078, AZD7762, PF.477736, LY2603618",0.183758700008217,0.0419141514789149,FALSE
+"HCC4006","Pearson.est","cyclooxygenase inhibitor",-0.35683,-0.849,0.696,1104,0.858,"ketoprofen, ramifenazone, tryptanthrin, acetylsalicylsalicylic.acid, meloxicam, indoprofen, piroxicam, FR.122047",0.157390760389438,0.0665127121512946,FALSE
+"HCC4006","Pearson.est","cytochrome P450 inhibitor",-0.41669,-1.01,0.478,1047,0.82,"PF.4981517, itraconazole, clotrimazole",0.320572103387881,0.0861861476162833,FALSE
+"HCC4006","Pearson.est","DNA alkylating agent",-0.23597,-0.569,0.941,534,0.967,"cisplatin, carmustine, ifosfamide, mitomycin.c, estramustine, streptozotocin, melphalan, carboplatin, temozolomide, TH.302",0.0264103765727431,0.0145735259169983,FALSE
+"HCC4006","Pearson.est","DNA inhibitor",-0.37558,-0.904,0.611,778,0.84,"valrubicin, tirapazamine, nimorazole, melphalan, carboplatin, chlorambucil, busulfan, bendamustine, pibenzimol, primaquine",0.213958789757446,0.0757207139381184,FALSE
+"HCC4006","Pearson.est","DNA methyltransferase inhibitor",-0.47854,-1.16,0.264,1059,0.667,"SGI.1027, fdcyd, RG108",0.578396073130169,0.175874166083451,FALSE
+"HCC4006","Pearson.est","DNA polymerase inhibitor",-0.47374,-1.12,0.312,1433,0.656,"idoxuridine",0.505845405981557,0.18309616062434,FALSE
+"HCC4006","Pearson.est","DNA synthesis inhibitor",-0.29886,-0.714,0.831,844,0.925,"capecitabine, enocitabine, floxuridine, nelarabine, cyclocytidine, CB.10.277, anisomycin, azodicarbonamide",0.080398976215889,0.0338582672609674,FALSE
+"HCC4006","Pearson.est","dopamine receptor antagonist",-0.25412,-0.614,0.914,883,0.954,"ziprasidone, nemonapride, UH.232...., paliperidone, piperacetazine, oxiperomide, mesoridazine",0.0390538042661686,0.0204516252959049,FALSE
+"HCC4006","Pearson.est","estrogen receptor agonist",-0.3835,-0.921,0.591,794,0.878,"equol, estrone, estradiol.cypionate, estradiol, PPT",0.228412519118745,0.0565054840938974,FALSE
+"HCC4006","Pearson.est","estrogen receptor antagonist",-0.50918,-1.23,0.209,985,0.581,"fulvestrant, tamoxifen, clomifene",0.679853713888946,0.235823867609669,FALSE
+"HCC4006","Pearson.est","FGFR inhibitor",-0.61008,-1.46,0.0623,1359,0.476,"lucitanib, AZD4547, nintedanib",1.20551195334083,0.322393047279507,FALSE
+"HCC4006","Pearson.est","FLT3 inhibitor",-0.37466,-0.902,0.611,1106,0.827,"tandutinib, lestaurtinib, TG.02, ENMD.2076, tozasertib, pacritinib",0.213958789757446,0.0824944904474534,FALSE
+"HCC4006","Pearson.est","glucocorticoid receptor agonist",-0.33853,-0.811,0.735,897,0.887,"dexamethasone.acetate, rimexolone, fluorometholone, halobetasol.propionate, prednisolone, difluprednate, deflazacort, clobetasol.propionate, halcinonide, methylprednisolone, flumethasone",0.133712660915805,0.0520763801682736,FALSE
+"HCC4006","Pearson.est","glutamate receptor antagonist",-0.29783,-0.716,0.827,740,0.938,"MTPG, diazooxonorleucine, latrepirdine, SIB.1757, tiletamine, CGP.37849, CPP, IEM1754",0.0824944904474534,0.0277971616209356,FALSE
+"HCC4006","Pearson.est","glycogen synthase kinase inhibitor",0.30716,0.933,0.536,1006,0.981,"TWS.119, LY2090314, kenpaullone, GSK.3.inhibitor.IX, indirubin, tideglusib, AZD2858, CHIR.99021, CHIR.98014",0.27083521030723,0.0083309926200515,FALSE
+"HCC4006","Pearson.est","growth factor receptor inhibitor",-0.71443,-1.71,0.0115,1148,0.71,"lestaurtinib, danusertib, AZD3463, GSK1838705A",1.93930215964639,0.148741651280925,FALSE
+"HCC4006","Pearson.est","HCV inhibitor",-0.37988,-0.931,0.559,1160,0.876,"embelin, narlaprevir",0.252588192113577,0.0574958938319193,FALSE
+"HCC4006","Pearson.est","HDAC inhibitor",-0.64704,-1.55,0.035,1149,0.608,"ACY.1215, chidamide, belinostat, mocetinostat, SB.939, PCI.24781, R306465, pyroxamide, givinostat, dacinostat, vorinostat, RG2833, resminostat, AR.42, M.344",1.45593195564972,0.216096420727265,FALSE
+"HCC4006","Pearson.est","histamine receptor antagonist",-0.34994,-0.834,0.716,704,0.867,"ebastine, pheniramine, ranitidine, terfenadine, epinastine, BF2.649, ICI.162846, astemizole, nizatidine, tecastemizole, tiotidine, cimetidine, levocetirizine",0.145086977692144,0.0619809025237897,FALSE
+"HCC4006","Pearson.est","HMGCR inhibitor",0.55687,1.68,0.0377,645,0.185,"pitavastatin, mevastatin, fluvastatin, atorvastatin, lovastatin, simvastatin",1.42365864979421,0.732828271596986,TRUE
+"HCC4006","Pearson.est","HSP inhibitor",-0.37796,-0.917,0.593,591,0.867,"SNX.5422, NVP.AUY922, alvespimycin, KW.2478, guanidine, NMS.E973, tanespimycin, SNX.2112, PU.H71, XL888, VER.49009",0.226945306635737,0.0619809025237897,FALSE
+"HCC4006","Pearson.est","JAK inhibitor",-0.53785,-1.28,0.178,1001,0.653,"TG.101209, atiprimod, filgotinib, lestaurtinib, AZD1480, TG.02, tozasertib, AT.9283, PRT062070, AZ960, pacritinib",0.749579997691106,0.185086818724926,FALSE
+"HCC4006","Pearson.est","KIT inhibitor",-0.47347,-1.13,0.305,870,0.653,"telatinib, dasatinib, regorafenib, cediranib, sunitinib, motesanib, KI.8751, tandutinib, vatalanib, imatinib",0.515700160653214,0.185086818724926,FALSE
+"HCC4006","Pearson.est","MDM inhibitor",-0.33969,-0.81,0.727,1417,0.873,"CGM097",0.138465589140962,0.0589857562944303,FALSE
+"HCC4006","Pearson.est","MEK inhibitor",0.17572,0.537,0.971,154,0.972,"PD.318088, BIX.02188, MEK162, MEK1.2.inhibitor",0.0127807700919951,0.0123337350737254,FALSE
+"HCC4006","Pearson.est","MET inhibitor",-0.5209,-1.24,0.176,1381,0.58,"AMG458",0.75448733218585,0.236572006437063,FALSE
+"HCC4006","Pearson.est","microtubule inhibitor",-0.43088,-1.03,0.44,1082,0.791,"triclabendazole, D.64131, secnidazole",0.356547323513813,0.101823516502323,FALSE
+"HCC4006","Pearson.est","mTOR inhibitor",-0.28087,-0.681,0.874,1212,0.944,"WYE.354, GSK2126458, palomid.529, LY303511",0.058488567365597,0.025028005701931,FALSE
+"HCC4006","Pearson.est","NFkB pathway inhibitor",-0.31977,-0.772,0.789,1442,0.884,"betulinic.acid",0.10292299679058,0.0535477349869269,FALSE
+"HCC4006","Pearson.est","opioid receptor agonist",-0.37101,-0.892,0.629,1207,0.814,"trimebutine, salvinorin.a",0.201349354554731,0.0893755951107988,FALSE
+"HCC4006","Pearson.est","p38 MAPK inhibitor",-0.40588,-0.977,0.517,833,0.834,"skepinone.l, SB.239063, talmapimod, VX.702",0.286509456906058,0.0788339493622613,FALSE
+"HCC4006","Pearson.est","PARP inhibitor",0.29796,0.849,0.664,85,0.869,"olaparib, niraparib",0.177831920631982,0.0609802235513335,FALSE
+"HCC4006","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.40247,-0.986,0.488,933,0.834,"dasatinib, regorafenib, sunitinib, motesanib, KI.8751, tandutinib, CP.673451, vatalanib, crenolanib, trapidil, imatinib, nintedanib",0.311580177997289,0.0788339493622613,FALSE
+"HCC4006","Pearson.est","phosphatase inhibitor",0.28841,0.888,0.585,79,0.974,"alexidine, mycophenolate.mofetil",0.23284413391782,0.0114410431213845,FALSE
+"HCC4006","Pearson.est","phosphodiesterase inhibitor",0.19889,0.609,0.935,1162,0.994,"avanafil, zardaverine, anagrelide, enoximone, papaverine, cilostamide, YM.976, GSK256066, trequinsin, EMD.53998",0.0291883891274822,0.00261361560268669,FALSE
+"HCC4006","Pearson.est","PI3K inhibitor",-0.3761,-0.912,0.595,1034,0.841,"buparlisib, CH5132799, TG.100713, alpelisib, GSK2126458, CUDC.907, PIK.75, taselisib, LY303511",0.22548303427145,0.0752040042020878,FALSE
+"HCC4006","Pearson.est","PLK inhibitor",-0.55783,-1.34,0.116,878,0.69,"GW.843682X, GSK461364, volasertib, NMS.1286937, BI.2536",0.935542010773082,0.161150909262745,FALSE
+"HCC4006","Pearson.est","potassium channel blocker",-0.44912,-1.08,0.354,1143,0.733,"oleoylethanolamide, mepivacaine",0.450996737974212,0.134896025358872,FALSE
+"HCC4006","Pearson.est","PPAR receptor agonist",-0.26486,-0.626,0.926,1143,0.96,"oleoylethanolamide, S26948",0.0333890133180656,0.0177287669604316,FALSE
+"HCC4006","Pearson.est","progesterone receptor agonist",0.69407,2.01,0,152,0.129,"norethindrone.acetate, norgestrel, norethindrone, dienogest, tanaproget, levonorgestrel",Inf,0.889410289700751,TRUE
+"HCC4006","Pearson.est","proteasome inhibitor",-0.4007,-0.959,0.516,634,0.856,"delanzomib, oprozomib, ixazomib.citrate, carfilzomib, MG.132, bortezomib, ixazomib",0.287350298372789,0.0675262353228468,FALSE
+"HCC4006","Pearson.est","protein synthesis inhibitor",-0.33867,-0.79,0.757,1155,0.873,"homoharringtonine, anguidine, thiostrepton, bruceantin, puromycin",0.120904120499927,0.0589857562944303,FALSE
+"HCC4006","Pearson.est","protein tyrosine kinase inhibitor",-0.52812,-1.27,0.189,871,0.582,"AV.412, rheochrysidin, NVP.TAE226, tyrphostin.A9, BMS.599626, CP.724714",0.723538195826756,0.235077015350112,FALSE
+"HCC4006","Pearson.est","RAF inhibitor",-0.33344,-0.806,0.748,1211,0.864,"CEP.32496, TAK.632, AZ.628",0.126098402135539,0.0634862575211067,FALSE
+"HCC4006","Pearson.est","RET tyrosine kinase inhibitor",-0.62265,-1.49,0.0585,934,0.442,"regorafenib, sunitinib, apatinib, cabozantinib",1.23284413391782,0.354577730650908,FALSE
+"HCC4006","Pearson.est","retinoid receptor agonist",0.43819,1.34,0.124,817,0.339,"adapalene, LE.135, bexarotene, adarotene, tamibarotene, AM.580, CD.437, fenretinide",0.906578314837765,0.469800301796918,FALSE
+"HCC4006","Pearson.est","ribonucleotide reductase inhibitor",-0.52703,-1.27,0.177,1187,0.582,"gemcitabine, fludarabine, fludarabine.phosphate, clofarabine",0.752026733638193,0.235077015350112,FALSE
+"HCC4006","Pearson.est","serotonin receptor agonist",-0.51884,-1.26,0.19,1048,0.582,"zolmitriptan, aripiprazole, ipsapirone",0.721246399047171,0.235077015350112,FALSE
+"HCC4006","Pearson.est","serotonin receptor antagonist",-0.37384,-0.9,0.594,1065,0.815,"paliperidone, aripiprazole, SB.216641, SB.228357, RS.16566",0.226213555018806,0.0888423912600234,FALSE
+"HCC4006","Pearson.est","sodium channel blocker",-0.57382,-1.37,0.113,1361,0.71,"butamben, triamterene, mepivacaine, quinidine",0.94692155651658,0.148741651280925,FALSE
+"HCC4006","Pearson.est","src inhibitor",-0.55441,-1.31,0.145,933,0.688,"dasatinib, KX2.391, TG.100572, saracatinib, PP.1, ZM.306416, bosutinib",0.838631997765025,0.162411561764489,FALSE
+"HCC4006","Pearson.est","sterol demethylase inhibitor",0.53398,1.61,0.0222,678,0.179,"sulconazole, chlormidazole, lanoconazole, ketoconazole, terconazole, posaconazole",1.65364702554936,0.747146969020107,TRUE
+"HCC4006","Pearson.est","TGF beta receptor inhibitor",-0.66002,-1.57,0.0274,980,0.698,"SB.431542, LY2109761, repsox, D.4476, SB.525334",1.56224943717961,0.156144577376839,FALSE
+"HCC4006","Pearson.est","thymidylate synthase inhibitor",-0.49653,-1.22,0.209,716,0.581,"trifluridine, capecitabine, doxifluridine, ftorafur, carmofur, raltitrexed",0.679853713888946,0.235823867609669,FALSE
+"HCC4006","Pearson.est","topoisomerase inhibitor",0.21667,0.612,0.938,64,1,"etoposide.phosphate, epirubicin, doxorubicin, beta.lapachone",0.0277971616209356,0,FALSE
+"HCC4006","Pearson.est","tubulin polymerization inhibitor",-0.38205,-0.916,0.583,849,0.851,"albendazole, docetaxel, mebendazole, combretastatin.A.4, KX2.391, parbendazole, fosbretabulin, epothilone.b, epothilone.d, oxibendazole, flubendazole, ABT.751, plinabulin",0.234331445240986,0.0700704399154121,FALSE
+"HCC4006","Pearson.est","tyrosine kinase inhibitor",-0.54386,-1.31,0.144,933,0.688,"dasatinib, regorafenib, sunitinib, rheochrysidin, NVP.TAE226, AMG.208, tyrphostin.A9, BMS.599626, apatinib, CP.724714, tyrphostin.AG.99, aminopurvalanol.a, UNC2250, cabozantinib",0.84163750790475,0.162411561764489,FALSE
+"HCC4006","Pearson.est","VEGFR inhibitor",-0.36958,-0.874,0.638,934,0.83,"regorafenib, cediranib, golvatinib, sunitinib, motesanib, TG.100572, KI.8751, ZM.306416, foretinib, ENMD.2076, vatalanib, lucitanib, XL.647, cabozantinib, AEE788, nintedanib",0.195179321278838,0.0809219076239261,FALSE
+"HCC4006","Pearson.est","vitamin D receptor agonist",-0.64015,-1.52,0.0486,1227,0.589,"doxercalciferol, maxacalcitol, alfacalcidol, tacalcitol",1.31336373073771,0.229884705212898,FALSE
+"HCC2279","Pearson.est","EGFR inhibitor",0.22676,0.551,0.957,205,0.973,"tucatinib, salvianolic.acid.B, dovitinib, BMS.599626, neratinib, AST.1306",0.0190880622231565,0.0118871597316481,FALSE
+"HCC2279","Pearson.est","Abl kinase inhibitor",0.41009,0.997,0.466,691,0.701,"flumatinib, metatinib, ponatinib, imatinib, ZM.306416, bafetinib, bosutinib, nilotinib",0.33161408331,0.154281982033341,FALSE
+"HCC2279","Pearson.est","acetylcholine receptor agonist",0.35607,0.877,0.605,699,0.767,"xanomeline, oxiracetam, tremorine, pilocarpine, nefiracetam",0.218244625347531,0.115204636051019,FALSE
+"HCC2279","Pearson.est","acetylcholine receptor antagonist",0.53339,1.3,0.171,637,0.488,"darifenacin, methscopolamine, dicycloverine, hyoscyamine, diphemanil",0.767003889607846,0.311580177997289,FALSE
+"HCC2279","Pearson.est","adenosine receptor antagonist",0.55354,1.36,0.129,100,0.437,"PSB.1115, istradefylline",0.889410289700751,0.359518563029578,FALSE
+"HCC2279","Pearson.est","adrenergic receptor agonist",0.32801,0.79,0.703,348,0.805,"clenbuterol, buphenine, metaraminol, midodrine, methyldopa",0.153044674980176,0.0942041196321315,FALSE
+"HCC2279","Pearson.est","adrenergic receptor antagonist",0.29171,0.717,0.807,615,0.854,"atenolol...., idazoxan, prazosin, atenolol......, practolol, dronedarone, RS.17053, levobunolol, pindolol, oxprenolol",0.0931264652779296,0.068542129310995,FALSE
+"HCC2279","Pearson.est","AKT inhibitor",0.3788,0.925,0.542,258,0.754,"A.674563, uprosertib, GDC.0068",0.266000713461613,0.122628654130226,FALSE
+"HCC2279","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39437,0.962,0.515,514,0.726,"DMH1, CEP.37440, SB.505124, AZD3463, GW.788388, NVP.TAE684, crizotinib",0.288192770958809,0.139063379299906,FALSE
+"HCC2279","Pearson.est","androgen receptor antagonist",-0.46351,-1.33,0.125,1178,0.622,"bicalutamide, nilutamide",0.903089986991944,0.206209615309181,FALSE
+"HCC2279","Pearson.est","antioxidant",-0.38769,-1.06,0.348,1375,0.661,"chlorogenic.acid",0.458420756053419,0.17979854051436,FALSE
+"HCC2279","Pearson.est","AP inhibitor",0.35689,0.876,0.589,238,0.753,"embelin, LCL.161",0.229884705212898,0.123205023799299,FALSE
+"HCC2279","Pearson.est","ATPase inhibitor",0.45547,1.1,0.338,323,0.623,"digoxin, NMS.873, ouabain, omeprazole, evodiamine",0.471083299722345,0.20551195334083,FALSE
+"HCC2279","Pearson.est","Aurora kinase inhibitor",0.2194,0.533,0.964,528,0.965,"danusertib, barasertib.HQPA, alisertib, ENMD.2076, MK.8745, SNS.314, CCT137690, barasertib, PHA.680632",0.0159229660971692,0.0154726866562074,FALSE
+"HCC2279","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.6018,1.46,0.0764,543,0.407,"azalomycin.b, dirithromycin, tedizolid, valnemulin, josamycin, azithromycin",1.11690664142431,0.39040559077478,FALSE
+"HCC2279","Pearson.est","bacterial DNA gyrase inhibitor",-0.6279,-1.74,0.0302,1151,0.435,"norfloxacin, trovafloxacin, lomefloxacin, novobiocin, finafloxacin",1.51999305704285,0.361510743045363,FALSE
+"HCC2279","Pearson.est","BCL inhibitor",0.30983,0.764,0.735,108,0.824,"navitoclax",0.133712660915805,0.0840727883028842,FALSE
+"HCC2279","Pearson.est","Bcr.Abl kinase inhibitor",0.47075,1.16,0.285,393,0.588,"flumatinib, metatinib, ponatinib, imatinib",0.54515513999149,0.230622673923862,FALSE
+"HCC2279","Pearson.est","benzodiazepine receptor agonist",-0.34436,-0.951,0.473,1262,0.718,"CGS.20625, zaleplon, eprinomectin, bentazepam, ivermectin",0.325138859262188,0.1438755557577,FALSE
+"HCC2279","Pearson.est","bromodomain inhibitor",0.62378,1.53,0.0577,417,0.334,"I.BET151, I.BET.762, JQ1...., PFI.1",1.23882418684427,0.476253533188435,FALSE
+"HCC2279","Pearson.est","calcium channel blocker",0.61519,1.52,0.0637,209,0.321,"tetrandrine, efonidipine.monoethanolate, SKF.96365, penfluridol",1.19586056766465,0.493494967595128,FALSE
+"HCC2279","Pearson.est","CC chemokine receptor antagonist",-0.17627,-0.488,0.991,254,0.988,"SB.225002, RS.504393, PF.04136309, UNBS.5162, MK.0812, ZK811752, navarixin",0.00392634551472468,0.00524305541237188,FALSE
+"HCC2279","Pearson.est","CDK inhibitor",0.58463,1.45,0.0734,212,0.366,"ribociclib, AT.7519, abemaciclib, dinaciclib, palbociclib, JNJ.7706621, P276.00, PHA.848125, BMS.387032, PHA.793887",1.13430394008393,0.436518914605589,FALSE
+"HCC2279","Pearson.est","CHK inhibitor",0.51756,1.24,0.228,8,0.54,"PF.477736",0.642065152999546,0.267606240177031,FALSE
+"HCC2279","Pearson.est","cyclooxygenase inhibitor",-0.23515,-0.651,0.872,1089,0.922,"sulfasalazine, FR.122047, FK.3311, piroxicam, amfenac, metoxibutropate, AM.404, pterostilbene",0.0594835150674328,0.0352690789463706,FALSE
+"HCC2279","Pearson.est","cytochrome P450 inhibitor",0.34977,0.846,0.668,73,0.784,"morin",0.175223537524454,0.105683937315562,FALSE
+"HCC2279","Pearson.est","DNA alkylating agent",-0.2724,-0.768,0.719,1348,0.883,"dacarbazine, carboplatin, cyclophosphamide",0.143271109617117,0.0540392964224314,FALSE
+"HCC2279","Pearson.est","DNA inhibitor",0.26159,0.635,0.911,279,0.926,"primaquine, pibenzimol, oxaliplatin, bendamustine",0.0404816230270017,0.0333890133180656,FALSE
+"HCC2279","Pearson.est","DNA methyltransferase inhibitor",0.63427,1.53,0.0557,281,0.334,"SGI.1027, fdcyd, azacitidine",1.25414480482627,0.476253533188435,FALSE
+"HCC2279","Pearson.est","DNA polymerase inhibitor",0.47756,1.16,0.281,305,0.588,"trifluridine, adefovir.dipivoxil, idoxuridine",0.55129368009492,0.230622673923862,FALSE
+"HCC2279","Pearson.est","DNA synthesis inhibitor",-0.41384,-1.16,0.248,1314,0.577,"estramustine.phosphate, nelarabine, CB.10.277, altretamine",0.605548319173784,0.238824186844269,FALSE
+"HCC2279","Pearson.est","dopamine receptor antagonist",-0.47482,-1.32,0.152,1182,0.554,"amisulpride, isofloxythepin, nemonapride, domperidone, acetophenazine, remoxipride, oxiperomide, clebopride, thioproperazine",0.818156412055227,0.25649023527157,FALSE
+"HCC2279","Pearson.est","estrogen receptor agonist",-0.32708,-0.917,0.509,471,0.698,"erteberel, equol, estradiol, PPT, levonorgestrel, estrone, ethinyl.estradiol, estradiol.cypionate",0.293282217663241,0.156144577376839,FALSE
+"HCC2279","Pearson.est","estrogen receptor antagonist",0.40483,1,0.455,186,0.714,"tamoxifen, clomifene",0.341988603342888,0.146301788223826,FALSE
+"HCC2279","Pearson.est","FGFR inhibitor",0.77841,1.92,0.00431,124,0.149,"lucitanib, erdafitinib, dovitinib, PD.173074, regorafenib, nintedanib",2.36552272983927,0.826813731587726,TRUE
+"HCC2279","Pearson.est","FLT3 inhibitor",0.51119,1.27,0.185,314,0.527,"sorafenib, dovitinib, pacritinib, ENMD.2076, tandutinib, gilteritinib, ponatinib, sunitinib",0.732828271596986,0.278189384787453,FALSE
+"HCC2279","Pearson.est","glucocorticoid receptor agonist",-0.42072,-1.14,0.285,1098,0.563,"flumethasone.pivalate, clobetasol.propionate, dexamethasone.acetate, triamcinolone, piretanide, fludroxycortide, methylprednisolone, fluocinolone.acetonide, desonide, prednisolone.acetate, triamcinolone.acetonide, prednisolone, ciclesonide, hydrocortisone",0.54515513999149,0.249491605148654,FALSE
+"HCC2279","Pearson.est","glutamate receptor antagonist",-0.37282,-1.04,0.376,1383,0.651,"MTPG, latrepirdine, SIB.1757",0.424812155072339,0.186419011431808,FALSE
+"HCC2279","Pearson.est","glycogen synthase kinase inhibitor",-0.28214,-0.759,0.699,406,0.855,"CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX, kenpaullone, tideglusib, indirubin, LY2090314, TWS.119, AZD2858",0.155522824254319,0.0680338852718274,FALSE
+"HCC2279","Pearson.est","growth factor receptor inhibitor",0.5941,1.45,0.094,142,0.366,"GSK1838705A, danusertib, PHA.848125",1.0268721464003,0.436518914605589,FALSE
+"HCC2279","Pearson.est","HCV inhibitor",0.39428,0.953,0.502,104,0.724,"embelin, mericitabine",0.299296282854981,0.140261433802853,FALSE
+"HCC2279","Pearson.est","HDAC inhibitor",-0.25526,-0.72,0.774,1387,0.874,"mocetinostat, tacedinaline, JNJ.26481585",0.111259039317107,0.058488567365597,FALSE
+"HCC2279","Pearson.est","histamine receptor antagonist",-0.35771,-0.977,0.411,1159,0.718,"epinastine, nizatidine, ranitidine, lafutidine, terfenadine, famotidine, chloropyramine",0.386158178123931,0.1438755557577,FALSE
+"HCC2279","Pearson.est","HMGCR inhibitor",-0.72232,-2.03,0.0108,1326,0.187,"mevastatin, fluvastatin, pitavastatin",1.96657624451305,0.728158393463501,TRUE
+"HCC2279","Pearson.est","HSP inhibitor",0.4358,1.07,0.384,554,0.606,"NMS.E973, XL888, NVP.AUY922, KW.2478, SNX.2112, alvespimycin, SNX.5422",0.415668775632469,0.217527375833714,FALSE
+"HCC2279","Pearson.est","JAK inhibitor",0.46065,1.13,0.318,579,0.626,"pacritinib, AZ960, TG.101209, AZD1480, PRT062070, TG.02, filgotinib, TG.101348, lestaurtinib, baricitinib, atiprimod",0.497572880015567,0.20342566678957,FALSE
+"HCC2279","Pearson.est","KIT inhibitor",0.6352,1.56,0.0388,393,0.563,"pazopanib, sorafenib, regorafenib, cediranib, masitinib, telatinib, tandutinib, sunitinib, OSI.930, lenvatinib, imatinib",1.41116827440579,0.249491605148654,FALSE
+"HCC2279","Pearson.est","MDM inhibitor",-0.49762,-1.4,0.131,1101,0.596,"AMG.232, idasanutlin, serdemetan, RITA",0.882728704344236,0.224753740259764,FALSE
+"HCC2279","Pearson.est","MEK inhibitor",-0.42828,-1.2,0.233,1139,0.624,"AZD8330, U.0126, TAK.733, Ro.4987655, MEK162, PD.318088, PD.184352, PD.98059, PD.198306, refametinib",0.632644078973981,0.204815410317576,FALSE
+"HCC2279","Pearson.est","MET inhibitor",0.45102,1.08,0.394,388,0.622,"INC.280, AMG458, PHA.665752, LY2801653",0.404503778174426,0.206209615309181,FALSE
+"HCC2279","Pearson.est","microtubule inhibitor",0.54118,1.32,0.15,241,0.494,"D.64131, vinflunine, cytochalasin.b, triclabendazole",0.823908740944319,0.306273051076353,FALSE
+"HCC2279","Pearson.est","mTOR inhibitor",0.4737,1.17,0.288,340,0.634,"WYE.125132, torin.2, temsirolimus, WYE.354, AZD2014, OSI.027, deforolimus, voxtalisib, everolimus, PKI.179, LY3023414, AZD8055, XL388",0.540607512240769,0.197910742118267,FALSE
+"HCC2279","Pearson.est","NFkB pathway inhibitor",0.44322,1.08,0.358,337,0.622,"Ro.106.9920, betulinic.acid, EVP4593, IKK.2.inhibitor.V, bortezomib",0.446116973356126,0.206209615309181,FALSE
+"HCC2279","Pearson.est","opioid receptor agonist",-0.31128,-0.849,0.611,1408,0.783,"BW.180C",0.213958789757446,0.106238237942057,FALSE
+"HCC2279","Pearson.est","p38 MAPK inhibitor",-0.41901,-1.17,0.253,1440,0.614,"CMPD.1",0.596879478824182,0.211831628858832,FALSE
+"HCC2279","Pearson.est","PARP inhibitor",0.36561,0.905,0.575,769,0.771,"PJ.34, endo.IWR.1, E7449, AZD2461, talazoparib, olaparib",0.24033215531037,0.112945621949043,FALSE
+"HCC2279","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.57679,1.41,0.104,393,0.388,"pazopanib, sorafenib, dovitinib, regorafenib, nintedanib, masitinib, telatinib, tandutinib, CP.673451, crenolanib, ponatinib, sunitinib, lenvatinib, imatinib",0.98296666070122,0.411168274405793,FALSE
+"HCC2279","Pearson.est","phosphatase inhibitor",0.40398,0.987,0.478,335,0.701,"GSK2830371, CID.5458317, sodium.stibogluconate, AS.1949490",0.320572103387881,0.154281982033341,FALSE
+"HCC2279","Pearson.est","phosphodiesterase inhibitor",0.30127,0.736,0.792,455,0.846,"trequinsin, cilostamide, papaverine, enoximone",0.101274818410506,0.0726296369609765,FALSE
+"HCC2279","Pearson.est","PI3K inhibitor",0.36044,0.88,0.634,618,0.778,"BGT226, buparlisib, CH5132799, voxtalisib, PKI.179, LY3023414, taselisib, PI3K.IN.2, PI.828, LY303511, TG100.115, idelalisib, AZD6482, CUDC.907, PF.05212384, PF.04691502, PIK.75",0.197910742118267,0.109020403010311,FALSE
+"HCC2279","Pearson.est","PLK inhibitor",0.70889,1.76,0.0167,239,0.335,"volasertib, NMS.1286937, GW.843682X, rigosertib",1.77728352885242,0.474955192963155,FALSE
+"HCC2279","Pearson.est","potassium channel blocker",0.33607,0.833,0.679,365,0.788,"dofetilide, mepivacaine, ML133",0.168130225719498,0.103473782510445,FALSE
+"HCC2279","Pearson.est","PPAR receptor agonist",-0.57111,-1.55,0.0758,1183,0.442,"S26948, pterostilbene, clofibrate",1.12033079436795,0.354577730650908,FALSE
+"HCC2279","Pearson.est","progesterone receptor agonist",-0.60097,-1.65,0.0391,1249,0.406,"tanaproget, norethindrone, norgestrel, norethindrone.acetate",1.40782324260413,0.391473966422806,FALSE
+"HCC2279","Pearson.est","proteasome inhibitor",0.45276,1.11,0.342,426,0.624,"MG.132, oprozomib, bortezomib, carfilzomib",0.465973893943865,0.204815410317576,FALSE
+"HCC2279","Pearson.est","protein synthesis inhibitor",0.33009,0.796,0.708,282,0.812,"puromycin, tedizolid.phosphate, harringtonine, bruceantin, anguidine, homoharringtonine",0.149966742310231,0.0904439707588247,FALSE
+"HCC2279","Pearson.est","protein tyrosine kinase inhibitor",0.65592,1.62,0.0314,473,0.488,"BMS.599626, AV.412, rheochrysidin, mubritinib, tyrphostin.A9, CP.724714, NVP.TAE226",1.50307035192679,0.311580177997289,FALSE
+"HCC2279","Pearson.est","RAF inhibitor",0.71294,1.75,0.0151,92,0.246,"GDC.0879, sorafenib, RAF265, dabrafenib, TAK.632, regorafenib",1.82102305270683,0.609064892896621,TRUE
+"HCC2279","Pearson.est","RET tyrosine kinase inhibitor",0.6351,1.54,0.0562,314,0.395,"sorafenib, regorafenib, apatinib, sunitinib",1.25026368443094,0.40340290437354,FALSE
+"HCC2279","Pearson.est","retinoid receptor agonist",0.37577,0.896,0.589,221,0.769,"adarotene, fenretinide",0.229884705212898,0.114073660198569,FALSE
+"HCC2279","Pearson.est","ribonucleotide reductase inhibitor",0.52812,1.3,0.175,391,0.488,"pentostatin, fludarabine.phosphate, LY2334737, cladribine",0.756961951313706,0.311580177997289,FALSE
+"HCC2279","Pearson.est","serotonin receptor agonist",0.62996,1.54,0.043,398,0.395,"zolmitriptan, pardoprunox, ipsapirone, aripiprazole",1.36653154442041,0.40340290437354,FALSE
+"HCC2279","Pearson.est","serotonin receptor antagonist",0.43517,1.07,0.366,653,0.606,"sertindole, lurasidone, SB.216641, aripiprazole, SB.200646, pirenperone, lerisetron, paliperidone, RS.16566, SB.228357, ziprasidone",0.436518914605589,0.217527375833714,FALSE
+"HCC2279","Pearson.est","sodium channel blocker",0.4397,1.11,0.331,648,0.624,"lappaconite, mepivacaine, butamben, triamterene, quinidine, benzethonium, cibenzoline, oxcarbazepine",0.480172006224281,0.204815410317576,FALSE
+"HCC2279","Pearson.est","src inhibitor",0.63045,1.54,0.0554,235,0.395,"TG.100572, PP.1, masitinib, saracatinib",1.25649023527157,0.40340290437354,FALSE
+"HCC2279","Pearson.est","sterol demethylase inhibitor",-0.43252,-1.2,0.253,1209,0.624,"ketoconazole, lanoconazole, terconazole",0.596879478824182,0.204815410317576,FALSE
+"HCC2279","Pearson.est","TGF beta receptor inhibitor",0.50624,1.25,0.234,718,0.544,"LY2109761, adaprev, D.4476, SB.431542, SB.525334, repsox",0.630784142589857,0.26440110030182,FALSE
+"HCC2279","Pearson.est","thymidylate synthase inhibitor",0.56941,1.37,0.119,128,0.444,"trifluridine, capecitabine",0.924453038607469,0.35261702988538,FALSE
+"HCC2279","Pearson.est","topoisomerase inhibitor",0.33749,0.819,0.689,341,0.794,"etoposide.phosphate, SN.38, daunorubicin, topotecan, dexrazoxane, irinotecan, fleroxacin",0.161780778092374,0.100179497572904,FALSE
+"HCC2279","Pearson.est","tubulin polymerization inhibitor",0.4851,1.19,0.262,545,0.617,"vindesine, albendazole, paclitaxel, docetaxel, vincristine, parbendazole, vinorelbine, combretastatin.A.4, ABT.751, flubendazole, taltobulin, plinabulin, fosbretabulin, fenbendazole, CYT.997, verubulin, vinblastine",0.581698708680255,0.209714835966758,FALSE
+"HCC2279","Pearson.est","tyrosine kinase inhibitor",0.48175,1.16,0.287,408,0.588,"tivantinib, sorafenib, regorafenib, BMS.599626, AV.412, hypericin, apatinib, aminopurvalanol.a, sunitinib, rheochrysidin, mubritinib, tyrphostin.A9, CP.724714",0.542118103266008,0.230622673923862,FALSE
+"HCC2279","Pearson.est","VEGFR inhibitor",0.58025,1.44,0.0952,326,0.359,"TG.100572, foretinib, pazopanib, lucitanib, sorafenib, RAF265, golvatinib, dovitinib, PD.173074, regorafenib, nintedanib, cediranib, tivozanib, ENMD.2076, telatinib, AEE788, sunitinib, OSI.930",1.02136305161553,0.444905551421681,FALSE
+"HCC2279","Pearson.est","vitamin D receptor agonist",-0.34499,-0.948,0.518,1266,0.681,"ercalcitriol, calcitriol",0.285670240254767,0.166852888087215,FALSE
+"H520","Pearson.est","EGFR inhibitor",-0.43523,-1.07,0.373,831,0.729,"BIBU.1361, canertinib, PD.168393, icotinib, WZ.3146, pelitinib, XL.647, rociletinib, lapatinib, erlotinib, WZ8040, neratinib, ARRY.334543, tyrphostin.AG.1478, dacomitinib, WZ.4002, poziotinib, BIBX.1382, gefitinib, CNX.2006, tucatinib, AST.1306, AZD8931, CP.724714, CUDC.101",0.428291168191312,0.137272471682025,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",0.5935,1.66,0.0508,341,0.204,"GZD824, ponatinib, bafetinib, metatinib, dasatinib, tozasertib, imatinib, flumatinib",1.29413628771608,0.690369832574101,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",-0.46921,-1.16,0.283,1175,0.687,"nefiracetam, oxiracetam, pilocarpine",0.54821356447571,0.16304326294045,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",-0.48604,-1.19,0.261,1057,0.691,"dicycloverine, methscopolamine, diphemanil",0.583359492661719,0.160521952625802,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",-0.5699,-1.41,0.0948,876,0.482,"MRS.1220, PSB.1115, CGS.15943, theophylline, SCH.58261",1.02319166266193,0.31695296176115,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.3651,1.04,0.356,255,0.628,"terbutaline, metaraminol, epinephrine, buphenine, oxymetazoline, clenbuterol",0.448550002027125,0.202040356262804,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",-0.37159,-0.907,0.551,869,0.895,"dronedarone, pindolol, oxprenolol, imiloxan, atenolol...., propranolol, carvedilol, levobunolol, RS.17053, atenolol......, prazosin",0.258848401148215,0.048176964684088,FALSE
+"H520","Pearson.est","AKT inhibitor",-0.35935,-0.886,0.599,950,0.857,"A.674563, GSK2110183, palomid.529, CCT128930, uprosertib, AT7867",0.222573177610689,0.0670191780768018,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39813,1.08,0.333,483,0.622,"lorlatinib, brigatinib, CEP.37440, NVP.TAE684, alectinib, crizotinib, DMH1, GW.788388",0.47755576649368,0.206209615309181,FALSE
+"H520","Pearson.est","androgen receptor antagonist",-0.42438,-1.04,0.395,896,0.711,"flutamide, RU.58841, bicalutamide",0.40340290437354,0.148130399270234,FALSE
+"H520","Pearson.est","antioxidant",-0.56271,-1.38,0.12,1060,0.469,"chlorogenic.acid, rutin, trolox, taurine",0.920818753952375,0.328827157284917,FALSE
+"H520","Pearson.est","AP inhibitor",0.31101,0.861,0.554,291,0.764,"LCL.161, birinapant, GDC.0152",0.25649023527157,0.11690664142431,FALSE
+"H520","Pearson.est","ATPase inhibitor",-0.56151,-1.38,0.127,1201,0.469,"digitoxigenin, evodiamine, rabeprazole, ouabain, digoxin, k.strophanthidin",0.896196279044043,0.328827157284917,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.4342,-1.05,0.405,820,0.716,"alisertib, ZM.447439, CCT137690, GSK1070916, SNS.314, PF.03814735, ENMD.2076, barasertib.HQPA, barasertib, AMG900, AT.9283, MK.8745, danusertib, CCT129202, PHA.680632",0.392544976785331,0.145086977692144,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40094,-0.99,0.449,906,0.756,"josamycin, radezolid, tilmicosin, azalomycin.b",0.347753658996677,0.121478204498793,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.44378,1.21,0.226,14,0.535,"sparfloxacin, novobiocin",0.645891560852599,0.271646217978772,FALSE
+"H520","Pearson.est","BCL inhibitor",0.50644,1.45,0.105,189,0.316,"navitoclax, oridonin, gossypol, HA14.1, ABT.737",0.978810700930062,0.500312917381596,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.6257,1.72,0.0251,341,0.212,"GZD824, ponatinib, bafetinib, metatinib, dasatinib, tozasertib, imatinib, flumatinib",1.60032627851896,0.673664139071249,TRUE
+"H520","Pearson.est","benzodiazepine receptor agonist",-0.36206,-0.89,0.608,1049,0.874,"temazepam, nefiracetam, bentazepam, eprinomectin",0.216096420727265,0.058488567365597,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.73664,-1.76,0.00992,1166,0.201,"OTX015, JQ1...., I.BET.762, I.BET151",2.00348832784582,0.696803942579511,TRUE
+"H520","Pearson.est","calcium channel blocker",-0.25837,-0.629,0.893,1401,1,"mibefradil",0.0491485411114536,0,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",0.33531,0.928,0.527,343,0.699,"navarixin, UNBS.5162, RS.504393, ZK811752, MK.0812",0.278189384787453,0.155522824254319,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.34747,-0.851,0.628,1033,0.846,"PHA.793887, arcyriaflavin.a, TG.02, indisulam, aminopurvalanol.a, CR8..R., indirubin, BMS.387032, R547",0.202040356262804,0.0726296369609765,FALSE
+"H520","Pearson.est","CHK inhibitor",0.71942,1.93,0.0161,155,0.117,"SCH.900776, LY2606368, AZD7762, LY2603618",1.79317412396815,0.931814138253838,TRUE
+"H520","Pearson.est","cyclooxygenase inhibitor",-0.26074,-0.649,0.87,819,1,"piroxicam, phenazone, sulfasalazine, meloxicam, FK.3311, ketoprofen, tryptanthrin, tepoxalin, AM.404, aspirin, amfenac, naproxen",0.0604807473813815,0,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.38038,1.08,0.346,342,0.622,"itraconazole, eplerenone, clotrimazole, metyrapone",0.460923901207223,0.206209615309181,FALSE
+"H520","Pearson.est","DNA alkylating agent",0.3364,0.936,0.495,222,0.749,"dianhydrogalactitol, estramustine, carmustine, cisplatin, cyclophosphamide",0.305394801066431,0.125518182300534,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.55568,-1.34,0.139,1294,0.524,"bendamustine, carboplatin, nimorazole, metronidazole, mechlorethamine",0.856985199745905,0.280668713016273,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",0.51366,1.38,0.147,3,0.361,"decitabine",0.832682665251824,0.442492798094342,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",-0.5476,-1.32,0.167,798,0.497,"menadione, famciclovir, foscarnet, cephalomannine, idoxuridine, cidofovir",0.777283528852417,0.303643611266668,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.41571,-1.01,0.439,1369,0.744,"artesunate, artemisinin",0.357535479757879,0.128427064454121,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",-0.47152,-1.15,0.303,1070,0.647,"sertindole, ziprasidone, mesoridazine, amisulpride, raclopride, thioproperazine, remoxipride",0.518557371497695,0.1890957193313,FALSE
+"H520","Pearson.est","estrogen receptor agonist",-0.64061,-1.57,0.0344,1116,0.371,"PPT, estrone, erteberel, levonorgestrel",1.46344155742847,0.430626090384954,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",-0.43455,-1.07,0.385,1445,0.729,"clomifene",0.414539270491499,0.137272471682025,FALSE
+"H520","Pearson.est","FGFR inhibitor",0.22347,0.589,0.915,256,0.937,"erdafitinib, MK.2461, dovitinib",0.0385789059335517,0.0282604091122217,FALSE
+"H520","Pearson.est","FLT3 inhibitor",0.27369,0.769,0.786,256,0.86,"gilteritinib, ponatinib, sunitinib, lestaurtinib, tozasertib, dovitinib",0.104577453960592,0.0655015487564323,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",-0.62662,-1.51,0.0621,1004,0.349,"fluorometholone, triamcinolone, flumethasone, flumethasone.pivalate, rimexolone, triamcinolone.acetonide, deflazacort, fluocinolone.acetonide, ciclesonide, halcinonide, fluticasone.propionate, dexamethasone.acetate, prednisolone, betamethasone, difluprednate, methylprednisolone, desonide, hydrocortisone",1.20690839982342,0.45717457304082,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",-0.29769,-0.728,0.783,972,0.949,"CPP, IEM1754, CGP.37849, latrepirdine, tiletamine, ACDPP",0.106238237942057,0.0227337875727074,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.24438,0.673,0.852,128,0.884,"tideglusib, GSK.3.inhibitor.IX",0.0695604052332999,0.0535477349869269,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.33338,-0.82,0.659,1228,0.835,"GW.441756, danusertib",0.18111458540599,0.0783135245163979,FALSE
+"H520","Pearson.est","HCV inhibitor",-0.34422,-0.848,0.65,1184,0.809,"narlaprevir, PSI.7976",0.187086643357144,0.0920514783877277,FALSE
+"H520","Pearson.est","HDAC inhibitor",-0.2411,-0.601,0.94,857,0.983,"PCI.24781, scriptaid, givinostat, vorinostat, NSC.3852, panobinostat, M.344, entinostat, trichostatin.a, pyroxamide, RGFP966, mocetinostat",0.0268721464003014,0.00744648216786438,FALSE
+"H520","Pearson.est","histamine receptor antagonist",-0.35082,-0.86,0.637,1071,0.878,"ebastine, zolantidine, pheniramine, nizatidine, famotidine, ranitidine",0.19586056766465,0.0565054840938974,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.60774,1.71,0.0359,279,0.189,"mevastatin, atorvastatin, pitavastatin, simvastatin, lovastatin",1.44490555142168,0.723538195826756,TRUE
+"H520","Pearson.est","HSP inhibitor",-0.28386,-0.687,0.828,1029,0.981,"KW.2478, tanespimycin, XL888, PU.H71",0.0819696632151199,0.0083309926200515,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.48517,-1.18,0.279,1136,0.678,"AT.9283, TG.101348, atiprimod, pacritinib, WHI.P154, filgotinib, TG.101209, AZD1480, CEP.33779",0.554395796726402,0.168770306132937,FALSE
+"H520","Pearson.est","KIT inhibitor",0.37489,1.04,0.386,166,0.628,"KI.8751, pazopanib, sunitinib, dasatinib, motesanib",0.413412695328245,0.202040356262804,FALSE
+"H520","Pearson.est","MDM inhibitor",-0.8476,-2.07,0.00141,1259,0.024,"AMG.232, RITA, nutlin.3, idasanutlin, CGM097",2.85078088734462,1.61978875828839,TRUE
+"H520","Pearson.est","MEK inhibitor",0.56842,1.54,0.0884,170,0.28,"BIX.02188, cobimetinib, refametinib, TAK.733, AZD8330, arctigenin, trametinib, PD.98059, MEK162",1.05354773498693,0.552841968657781,FALSE
+"H520","Pearson.est","MET inhibitor",0.8637,2.29,0,119,0.0241,"NVP.BVU972, LY2801653, INC.280, PF.04217903",Inf,1.61798295742513,TRUE
+"H520","Pearson.est","microtubule inhibitor",-0.57439,-1.42,0.0835,1084,0.504,"vinblastine, triclabendazole, vinflunine, podophyllotoxin, cabazitaxel, secnidazole",1.0783135245164,0.297569463554475,FALSE
+"H520","Pearson.est","mTOR inhibitor",-0.34484,-0.857,0.63,850,0.859,"LY3023414, OSI.027, ku.0063794, PI.103, PKI.179, PP242, WYE.354, palomid.529, XL388, PF.04691502, LY303511, voxtalisib, WYE.125132, torin.1, AZD8055",0.200659450546418,0.0660068361687577,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",0.43122,1.17,0.277,77,0.568,"Ro.106.9920, BAY.11.7082, bortezomib, BAY.11.7085",0.557520230935551,0.245651664288981,FALSE
+"H520","Pearson.est","opioid receptor agonist",-0.45092,-1.1,0.339,1135,0.723,"salvinorin.a, trimebutine",0.469800301796918,0.140861702705469,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.69282,-1.68,0.0163,1314,0.276,"VX.702, skepinone.l, talmapimod",1.78781239559604,0.559090917934782,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.48775,-1.19,0.263,1251,0.691,"E7449, endo.IWR.1, AG.14361",0.580044251510242,0.160521952625802,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.40791,1.13,0.294,166,0.607,"SU014813, ponatinib, KI.8751, pazopanib, sunitinib, dasatinib, motesanib",0.531652669587843,0.216811308924742,FALSE
+"H520","Pearson.est","phosphatase inhibitor",0.27483,0.75,0.784,130,0.863,"BVT.948, alexidine",0.105683937315562,0.0639892042847904,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",-0.34937,-0.85,0.65,1349,0.826,"avanafil, cilostamide",0.187086643357144,0.0830199526796178,FALSE
+"H520","Pearson.est","PI3K inhibitor",-0.22716,-0.548,0.964,1332,0.958,"voxtalisib, AZD6482, YM.201636",0.0159229660971692,0.0186344909214556,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.5447,-1.32,0.157,1188,0.497,"HMN.214, NMS.1286937",0.804100347590766,0.303643611266668,FALSE
+"H520","Pearson.est","potassium channel blocker",0.2663,0.737,0.775,1064,0.827,"dofetilide, mepivacaine, meglitinide, oleoylethanolamide, ibutilide, ML133",0.11069829749369,0.0824944904474534,FALSE
+"H520","Pearson.est","PPAR receptor agonist",-0.2355,-0.583,0.945,671,0.975,"GW.501516, ciprofibrate, S26948, oleoylethanolamide, fenofibrate",0.0245681914907371,0.0109953843014632,FALSE
+"H520","Pearson.est","progesterone receptor agonist",-0.51982,-1.24,0.227,1256,0.643,"dienogest, levonorgestrel, norethindrone",0.643974142806877,0.191789027075778,FALSE
+"H520","Pearson.est","proteasome inhibitor",0.74325,2.08,0.0139,238,0.0955,"carfilzomib, bortezomib, ixazomib, delanzomib, ONX.0914",1.8569851997459,1.01999662841625,TRUE
+"H520","Pearson.est","protein synthesis inhibitor",-0.36739,-0.898,0.578,989,0.885,"florfenicol, methacycline, tedizolid.phosphate, harringtonine, azomycin..2.nitroimidazole., anguidine, cycloheximide, bruceantin",0.238072161579471,0.0530567293021746,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.62875,-1.53,0.0582,947,0.351,"mubritinib, PP.121, NVP.TAE226, AV.412, CP.724714",1.23507701535011,0.454692883534176,FALSE
+"H520","Pearson.est","RAF inhibitor",0.52071,1.5,0.0825,201,0.297,"vemurafenib, LGX818, SB.590885, dabrafenib",1.08354605145007,0.527243550682788,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",0.68111,1.86,0.0301,277,0.143,"sunitinib, cabozantinib, vandetanib",1.52143350440616,0.844663962534938,TRUE
+"H520","Pearson.est","retinoid receptor agonist",0.48573,1.32,0.159,192,0.409,"LE.135, CD.437, tamibarotene, fenretinide, AM.580",0.798602875679548,0.388276691992658,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",0.27239,0.749,0.742,108,0.836,"triapine, clofarabine",0.129596094720973,0.0777937225609836,FALSE
+"H520","Pearson.est","serotonin receptor agonist",-0.74938,-1.84,0.00438,1218,0.155,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",2.3585258894959,0.809668301829709,TRUE
+"H520","Pearson.est","serotonin receptor antagonist",-0.47542,-1.15,0.301,1061,0.647,"SB.200646, sertindole, ziprasidone, pirenperone, aripiprazole",0.521433504406157,0.1890957193313,FALSE
+"H520","Pearson.est","sodium channel blocker",-0.24758,-0.607,0.926,1157,0.999,"cibenzoline, A.803467, butamben",0.0333890133180656,0.000434511774017692,FALSE
+"H520","Pearson.est","src inhibitor",0.28577,0.785,0.72,148,0.865,"TG.100572, dasatinib",0.142667503568732,0.0629838925351858,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",-0.64178,-1.54,0.0546,1122,0.38,"chlormidazole, posaconazole, terconazole",1.26280735729526,0.42021640338319,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",-0.43278,-1.05,0.395,799,0.716,"LY2109761, adaprev, SB.525334, D.4476, SB.431542",0.40340290437354,0.145086977692144,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",0.36408,1,0.415,923,0.667,"doxifluridine, capecitabine, trifluridine, raltitrexed, carmofur, ftorafur",0.381951903287907,0.175874166083451,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",0.6655,1.94,0.0206,317,0.148,"irinotecan, topotecan, beta.lapachone, rubitecan, etoposide, daunorubicin, SN.38, doxorubicin, teniposide, epirubicin, nemorubicin, genz.644282, etoposide.phosphate, mitoxantrone, camptothecin, exatecan.mesylate",1.68613277963085,0.829738284605043,TRUE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.64246,-1.57,0.0579,1084,0.371,"vinblastine, fenbendazole, CYT.997, parbendazole, podophyllotoxin, verubulin, flubendazole, indibulin, dolastatin.10, plinabulin, vincristine, epothilone.d, KX2.391, epothilone.b, taltobulin, ABT.751, albendazole, nocodazole, vinorelbine",1.23732143627256,0.430626090384954,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",-0.22714,-0.56,0.964,920,0.97,"tyrphostin.AG.99, mubritinib, PP.121, NVP.TAE226, UNC2250, aminopurvalanol.a, AV.412, CP.724714, GTP.14564",0.0159229660971692,0.0132282657337552,FALSE
+"H520","Pearson.est","VEGFR inhibitor",0.34769,0.932,0.496,277,0.723,"foretinib, SU014813, KI.8751, pazopanib, sunitinib, golvatinib, TG.100572, cabozantinib, motesanib, MK.2461, tivozanib, dovitinib, vandetanib",0.304518323509803,0.140861702705469,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",0.31853,0.887,0.545,989,0.745,"paricalcitol, ercalcitriol, tacalcitol, maxacalcitol, calcitriol, alfacalcidol, doxercalciferol",0.263603497723358,0.127843727251707,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",0.35933,0.886,0.622,529,0.849,"BMS.599626, tucatinib, neratinib, osimertinib, BIBU.1361, OSI.420, AST.1306, lapatinib, AEE788, PD.153035, salvianolic.acid.B, XL.647, dovitinib, CP.724714, brigatinib, CUDC.101, BMS.690514, FERb.033, afatinib",0.206209615309181,0.0710923097560473,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",0.51676,1.26,0.202,360,0.693,"flumatinib, ZM.306416, metatinib, bafetinib, tozasertib, ponatinib",0.694648630553376,0.159266765388193,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",0.47913,1.19,0.254,540,0.703,"tremorine, xanomeline, nicotine",0.595166283380062,0.153044674980176,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",0.45441,1.08,0.366,513,0.794,"darifenacin, dicycloverine, methscopolamine",0.436518914605589,0.100179497572904,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",0.64055,1.54,0.0473,231,0.43,"PSB.1115, sulmazole",1.32513885926219,0.366531544420413,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",0.3485,0.861,0.637,411,0.836,"clenbuterol, metaraminol, isoetharine, terbutaline, epinephrine, oxymetazoline, ritodrine",0.19586056766465,0.0777937225609836,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",0.27381,0.676,0.843,787,0.991,"atipamezole, dronedarone, atenolol...., dihydroergocristine, oxprenolol, idazoxan, pindolol, practolol, levobunolol, vincamine, carvedilol, propranolol",0.0741724253752577,0.00392634551472468,FALSE
+"HCC15","Pearson.est","AKT inhibitor",-0.24426,-0.688,0.82,351,0.962,"palomid.529, A.674563, CCT128930, GDC.0068, AZD5363, uprosertib, AT7867, MK.2206, triciribine, GSK2110183, ONC201",0.0861861476162833,0.0168249279621871,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.40312,0.978,0.491,607,0.845,"DMH1, CEP.37440, GW.788388, AZD3463, brigatinib, SB.505124, crizotinib",0.308918507877032,0.0731432910503077,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.2705,-0.744,0.798,1242,0.976,"nilutamide, enzalutamide",0.0979971086492706,0.0105501823333082,FALSE
+"HCC15","Pearson.est","antioxidant",0.37804,0.931,0.549,184,0.828,"taurine",0.260427655549908,0.0819696632151199,FALSE
+"HCC15","Pearson.est","AP inhibitor",-0.41262,-1.17,0.279,595,0.605,"tanshinone.i, embelin, LCL.161, GDC.0152, idronoxil, birinapant",0.554395796726402,0.218244625347531,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",-0.46673,-1.33,0.149,1383,0.518,"rabeprazole, digitoxigenin, k.strophanthidin",0.826813731587726,0.285670240254767,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",0.2536,0.615,0.918,349,1,"ENMD.2076, alisertib, danusertib, ZM.447439, SNS.314, tozasertib",0.0371573187987575,0,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.50605,1.23,0.232,59,0.7,"dirithromycin, tedizolid",0.6345120151091,0.154901959985743,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",-0.26346,-0.766,0.739,1303,0.993,"norfloxacin, finafloxacin",0.131355561605174,0.00305075150461883,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.31107,0.763,0.755,379,0.917,"navitoclax, oridonin, gossypol",0.122053048370812,0.0376306643299789,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.50047,1.23,0.209,360,0.7,"flumatinib, metatinib, bafetinib, tozasertib, ponatinib",0.679853713888946,0.154901959985743,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.22212,0.55,0.954,49,1,"ZK.93423",0.0204516252959049,0,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.42025,1.03,0.433,842,0.806,"JQ1...., I.BET.762, PFI.1, I.BET151, bromosporine, OTX015",0.363512103646635,0.0936649581949093,FALSE
+"HCC15","Pearson.est","calcium channel blocker",0.45562,1.13,0.32,617,0.704,"penfluridol, SKF.96365, fendiline, efonidipine.monoethanolate, pranidipine, mibefradil, tetrandrine",0.494850021680094,0.152427340857888,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.53718,1.33,0.161,489,0.623,"RS.504393, MK.0812, UNBS.5162, PF.04136309, SB.225002",0.79317412396815,0.20551195334083,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.39908,0.96,0.523,419,0.813,"JNJ.7706621, abemaciclib, ribociclib, AT.7519, P276.00, PHA.793887, aminopurvalanol.a, palbociclib, kenpaullone, BMS.387032, R547",0.281498311132726,0.0899094544059319,FALSE
+"HCC15","Pearson.est","CHK inhibitor",0.29896,0.729,0.805,72,0.944,"PF.477736",0.0942041196321315,0.025028005701931,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.22632,-0.644,0.898,1313,0.927,"FK.3311, pterostilbene, amfenac, AM.404",0.0467236633326956,0.0329202658555029,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",0.5376,1.31,0.163,199,0.594,"itraconazole, morin",0.787812395596042,0.226213555018806,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",0.41313,1,0.457,101,0.821,"estramustine, ifosfamide, carmustine, melphalan",0.34008379993015,0.0856568428805592,FALSE
+"HCC15","Pearson.est","DNA inhibitor",0.3924,0.964,0.521,230,0.828,"primaquine, carmustine, melphalan, pibenzimol, bendamustine",0.283162276700476,0.0819696632151199,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.77446,1.92,0.00552,224,0.121,"SGI.1027, fdcyd, azacitidine, decitabine",2.2580609222708,0.91721462968355,TRUE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.35753,0.87,0.61,217,0.839,"trifluridine, idoxuridine",0.214670164989233,0.0762380391712997,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",-0.32688,-0.928,0.518,1386,0.838,"artesunate, altretamine",0.285670240254767,0.0767559813697235,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",-0.37326,-1.02,0.424,1280,0.704,"raclopride, oxiperomide, clebopride, remoxipride, thioproperazine",0.372634143407267,0.152427340857888,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",0.35792,0.873,0.623,95,0.853,"estradiol",0.20551195334083,0.069050968832477,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",0.46419,1.15,0.282,592,0.711,"tamoxifen, fulvestrant, toremifene, clomifene, danazol",0.549750891680639,0.148130399270234,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.55863,1.35,0.131,466,0.613,"MK.2461, nintedanib, lucitanib, erdafitinib, PD.173074, regorafenib, dovitinib",0.882728704344236,0.212539525481585,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.36646,0.899,0.592,368,0.846,"gilteritinib, tandutinib, ENMD.2076, tozasertib, ponatinib, sorafenib",0.22767829327708,0.0726296369609765,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.71385,-1.99,0.0122,1360,0.121,"fluticasone.propionate, fluocinolone.acetonide, prednisolone, flumethasone.pivalate, dexamethasone.acetate, triamcinolone.acetonide, ciclesonide, desonide, hydrocortisone",1.91364016932525,0.91721462968355,TRUE
+"HCC15","Pearson.est","glutamate receptor antagonist",-0.28167,-0.81,0.637,1240,0.965,"CPP, tiletamine, MTPG, latrepirdine",0.19586056766465,0.0154726866562074,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.24145,-0.658,0.876,1424,0.954,"indirubin",0.0574958938319193,0.0204516252959049,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",0.4641,1.13,0.311,227,0.704,"GSK1838705A, danusertib",0.507239610973163,0.152427340857888,FALSE
+"HCC15","Pearson.est","HCV inhibitor",-0.43354,-1.22,0.245,1444,0.646,"PSI.7976",0.610833915635468,0.189767482004916,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.36319,0.902,0.583,409,0.861,"RG2833, dacinostat, pyroxamide, R306465, M.344, belinostat, resminostat, chidamide, trichostatin.a, givinostat, RGFP966",0.234331445240986,0.0649968485463452,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",0.19439,0.479,0.985,111,1,"tiotidine, cimetidine",0.00656376950238827,0,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",-0.37154,-1.09,0.317,1131,0.689,"pitavastatin, lovastatin, fluvastatin",0.498940737782249,0.161780778092374,FALSE
+"HCC15","Pearson.est","HSP inhibitor",0.39029,0.952,0.529,192,0.809,"XL888, NMS.E973, SNX.5422",0.276544327964814,0.0920514783877277,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.21797,0.535,0.969,751,1,"AZD1480, baricitinib, tozasertib, AZ960, atiprimod, TG.02, lestaurtinib, WHI.P154, filgotinib",0.0136762229492347,0,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.48881,1.19,0.271,455,0.703,"pazopanib, motesanib, tandutinib, KI.8751, OSI.930, masitinib, sorafenib, regorafenib",0.567030709125594,0.153044674980176,FALSE
+"HCC15","Pearson.est","MDM inhibitor",-0.79879,-2.18,0.00391,1199,0.0704,"serdemetan, CGM097, AMG.232, idasanutlin, RITA",2.40782324260413,1.15242734085789,TRUE
+"HCC15","Pearson.est","MEK inhibitor",0.20659,0.505,0.966,346,1,"cobimetinib, trametinib, nobiletin, arctigenin",0.0150228735845067,0,FALSE
+"HCC15","Pearson.est","MET inhibitor",0.72518,1.75,0.015,228,0.339,"AMG458, LY2801653, NVP.BVU972, INC.280",1.82390874094432,0.469800301796918,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.33656,0.823,0.698,261,0.862,"D.64131, vinflunine",0.156144577376839,0.0644927341752872,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",-0.48758,-1.35,0.161,1179,0.567,"OSI.027, AZD8055, ku.0063794, MLN0128, PKI.179, GDC.0980, PI.103, WAY.600, sirolimus, PP242, SB.2343, torin.1",0.79317412396815,0.246416941107093,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.56765,1.37,0.121,93,0.609,"Ro.106.9920, bortezomib, betulinic.acid",0.91721462968355,0.215382707367125,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",0.41675,1.04,0.411,670,0.808,"trimebutine, salvinorin.a, cebranopadol, spiradoline",0.386158178123931,0.0925886392254138,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",0.25137,0.606,0.906,262,1,"SB.239063",0.0428718023231869,0,FALSE
+"HCC15","Pearson.est","PARP inhibitor",0.31816,0.786,0.734,40,0.901,"PJ.34",0.134303940083929,0.045275209020937,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.42724,1.04,0.415,466,0.808,"nintedanib, CP.673451, pazopanib, motesanib, tandutinib, KI.8751, masitinib, ponatinib, sorafenib, regorafenib, dovitinib",0.381951903287907,0.0925886392254138,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",-0.29944,-0.863,0.625,1443,0.915,"bis.maltolato.oxovanadium.IV.",0.204119982655925,0.0385789059335517,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",0.25337,0.625,0.91,234,1,"trequinsin, YM.976",0.0409586076789064,0,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",-0.21711,-0.623,0.902,1142,0.908,"pilaralisib, idelalisib, GDC.0941, PI3K.IN.2, ZSTK.474, PKI.179, GDC.0980, PI.103, YM.201636, SB.2343",0.0447934624580583,0.0419141514789149,FALSE
+"HCC15","Pearson.est","PLK inhibitor",0.66097,1.65,0.0254,342,0.287,"volasertib, GW.843682X, BI.2536, GSK461364, NMS.1286937",1.59516628338006,0.542118103266008,FALSE
+"HCC15","Pearson.est","potassium channel blocker",0.40635,1,0.453,289,0.821,"mepivacaine, dofetilide, ML133",0.343901797987168,0.0856568428805592,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.36886,-1.05,0.355,1316,0.703,"pterostilbene, clofibrate",0.449771646944906,0.153044674980176,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.55081,-1.55,0.0567,1265,0.34,"norethindrone.acetate, levonorgestrel, tanaproget, norgestrel, norethindrone",1.24641694110709,0.468521082957745,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.6327,1.54,0.0516,430,0.43,"bortezomib, carfilzomib, MG.132, ixazomib, delanzomib, oprozomib",1.28735029837279,0.366531544420413,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",-0.25361,-0.712,0.804,1228,0.976,"azomycin..2.nitroimidazole., mercaptopurine, methacycline, cycloheximide, brefeldin.a",0.0947439512515487,0.0105501823333082,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.42367,1.05,0.397,635,0.839,"BMS.599626, NVP.TAE226, tyrphostin.A9, CP.724714, rheochrysidin, mubritinib",0.401209493236885,0.0762380391712997,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.60764,1.46,0.0855,368,0.577,"GDC.0879, TAK.632, dabrafenib, SB.590885, RAF265, vemurafenib, LGX818, sorafenib",1.06803388527183,0.238824186844269,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.57105,1.37,0.11,455,0.609,"cabozantinib, apatinib, sorafenib, regorafenib",0.958607314841775,0.215382707367125,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",0.57188,1.38,0.101,517,0.696,"adarotene, tamibarotene, fenretinide, AM.580, CD.437, bexarotene",0.995678626217357,0.157390760389438,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.48748,1.2,0.235,747,0.744,"triapine, fludarabine, clofarabine, hydroxyurea, fludarabine.phosphate, gemcitabine, LY2334737, cytarabine, cladribine, pentostatin",0.628932137728264,0.128427064454121,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",-0.60023,-1.68,0.0746,1447,0.344,"aripiprazole",1.12726117252733,0.46344155742847,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",-0.43113,-1.19,0.237,1447,0.631,"aripiprazole",0.625251653989896,0.199970640755866,FALSE
+"HCC15","Pearson.est","sodium channel blocker",0.33855,0.847,0.644,671,0.841,"quinidine, mepivacaine, triamterene, ajmaline, oxcarbazepine, lappaconite, butamben, benzethonium",0.191114132640188,0.0752040042020878,FALSE
+"HCC15","Pearson.est","src inhibitor",0.58662,1.43,0.0819,316,0.603,"TG.100572, ZM.306416, PP.1, masitinib",1.08671609823958,0.219682687859849,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",-0.57879,-1.56,0.0679,1300,0.414,"lanoconazole, sulconazole, ketoconazole, terconazole",1.1681302257195,0.382999658879101,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.71319,1.72,0.0131,148,0.286,"LY2109761, D.4476, repsox",1.88272870434424,0.543633966870957,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.69939,1.69,0.0135,376,0.274,"trifluridine, raltitrexed, capecitabine, ftorafur, doxifluridine",1.86966623150499,0.562249437179612,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",0.47345,1.15,0.312,293,0.711,"exatecan.mesylate, topotecan, SN.38, irinotecan, etoposide, rubitecan, genz.644282, fleroxacin, daunorubicin, etoposide.phosphate",0.505845405981557,0.148130399270234,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.17652,0.441,0.993,426,0.992,"vindesine, paclitaxel, parbendazole, docetaxel, albendazole",0.00305075150461883,0.00348832784582135,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.40247,0.966,0.511,368,0.847,"BMS.599626, hypericin, tivantinib, cabozantinib, NVP.TAE226, aminopurvalanol.a, apatinib, tyrphostin.A9, bafetinib, sorafenib",0.291579099865287,0.0721165896692931,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.47355,1.17,0.267,252,0.722,"TG.100572, foretinib, MK.2461, nintedanib, lucitanib, golvatinib, pazopanib, motesanib, ZM.306416, cabozantinib, ENMD.2076, RAF265, KI.8751, OSI.930",0.573488738635425,0.141462802430361,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",0.52991,1.31,0.163,331,0.594,"tacalcitol, alfacalcidol",0.787812395596042,0.226213555018806,FALSE
+"H460","Pearson.est","EGFR inhibitor",-0.33654,-0.804,0.745,606,0.93,"vandetanib, GW.583340, afatinib, canertinib, lapatinib, AZD8931, OSI.420, dacomitinib, PD.168393, WZ.4002, AST.1306, erlotinib, FERb.033, BIBX.1382, icotinib, gefitinib, AEE788, WZ8040, pelitinib, CUDC.101, BIBU.1361, BMS.599626, neratinib, XL.647, osimertinib, rociletinib, salvianolic.acid.B, CP.724714, tucatinib",0.127843727251707,0.0315170514460649,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.42374,-1.03,0.429,1155,0.868,"tozasertib, flumatinib, KW.2449, bosutinib",0.367542707815276,0.0614802748235081,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.52174,-1.24,0.202,913,0.619,"oxiracetam, nefiracetam, xanomeline, pilocarpine",0.694648630553376,0.208309350979882,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",-0.35808,-0.863,0.65,598,0.946,"darifenacin, iododexetimide, hyoscyamine, dicycloverine, methscopolamine",0.187086643357144,0.0241088635982073,FALSE
+"H460","Pearson.est","adenosine receptor antagonist",-0.4405,-1.07,0.383,796,0.833,"istradefylline, SCH.58261, PSB.1115, theophylline, sulmazole",0.416801226031377,0.0793549985932124,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",-0.28779,-0.699,0.878,881,0.989,"buphenine, methyldopa, clenbuterol, epinephrine, isoetharine, midodrine",0.0565054840938974,0.0048037084028206,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",-0.20703,-0.495,0.972,808,0.996,"atenolol......, carvedilol, pindolol, dihydroergocristine, dronedarone, levobunolol, oxprenolol, idazoxan",0.0123337350737254,0.00174066157630127,FALSE
+"H460","Pearson.est","AKT inhibitor",-0.56143,-1.38,0.0929,1170,0.522,"uprosertib, palomid.529, CCT128930, AT7867",1.03198428600636,0.282329496997738,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31624,-0.763,0.802,826,0.96,"GW.788388, CEP.37440, AZD3463, DMH1, alectinib",0.0958256317158365,0.0177287669604316,FALSE
+"H460","Pearson.est","androgen receptor antagonist",-0.46354,-1.12,0.311,680,0.772,"enzalutamide, RU.58841, cyproterone.acetate, bicalutamide, flutamide",0.507239610973163,0.112382699664264,FALSE
+"H460","Pearson.est","antioxidant",-0.47259,-1.14,0.283,1009,0.741,"trolox, benfotiamine, taurine",0.54821356447571,0.130181792020672,FALSE
+"H460","Pearson.est","AP inhibitor",0.30028,0.903,0.613,1015,0.971,"birinapant, tanshinone.i, idronoxil, GDC.0152, embelin, LCL.161",0.212539525481585,0.0127807700919951,FALSE
+"H460","Pearson.est","ATPase inhibitor",-0.35642,-0.862,0.644,1035,0.93,"evodiamine, digitoxin, omeprazole, oligomycin.a, digoxin",0.191114132640188,0.0315170514460649,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.67101,-1.64,0.0126,1155,0.251,"tozasertib, CCT137690, CCT129202, KW.2449, ZM.447439, CYC116, alisertib, MK.8745, AMG900, barasertib.HQPA, PF.03814735, AT.9283, danusertib, ENMD.2076, SNS.314, hesperadin",1.89962945488244,0.600326278518962,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.52625,-1.28,0.166,879,0.666,"tilmicosin, radezolid, josamycin, dirithromycin, azalomycin.b, valnemulin",0.779891911959945,0.176525770829699,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.59375,1.71,0.0569,593,0.367,"sparfloxacin, finafloxacin, trovafloxacin, lomefloxacin, norfloxacin, nadifloxacin, sarafloxacin, novobiocin",1.24488773360493,0.435333935747911,FALSE
+"H460","Pearson.est","BCL inhibitor",-0.35416,-0.849,0.696,866,0.919,"ABT.737, venetoclax, gossypol, navitoclax, TW.37",0.157390760389438,0.0366844886138887,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.38812,-0.955,0.538,1155,0.862,"tozasertib, flumatinib, bosutinib",0.269217724333611,0.0644927341752872,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",-0.28999,-0.705,0.851,1025,0.999,"nefiracetam, piperazine, lorazepam",0.0700704399154121,0.000434511774017692,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.78849,-1.88,0.00113,1137,0.142,"OTX015, PFI.1, bromosporine, I.BET151, JQ1...., I.BET.762",2.94692155651658,0.847711655616944,TRUE
+"H460","Pearson.est","calcium channel blocker",0.23783,0.746,0.765,1106,1,"SKF.96365, fendiline, efonidipine.monoethanolate, penfluridol, cinnarazine, pranidipine, SR.33805, tetrandrine, carboxyamidotriazole, mibefradil",0.116338564846382,0,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.39548,-0.949,0.537,980,0.856,"RS.504393, PF.04136309, SB.225002, MK.0812",0.270025714300444,0.0675262353228468,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.56711,-1.37,0.103,1031,0.511,"TG.02, AT.7519, BMS.387032, palbociclib, indisulam, AZD5438, P276.00, PHA.793887, ribociclib, abemaciclib, BMS.265246, dinaciclib, R547, aminopurvalanol.a, JNJ.7706621",0.987162775294828,0.291579099865287,FALSE
+"H460","Pearson.est","CHK inhibitor",-0.38873,-0.938,0.554,1176,0.862,"SB.218078, PF.477736",0.25649023527157,0.0644927341752872,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.28997,-0.694,0.878,819,0.979,"indoprofen, suxibuzone, meloxicam, aspirin, FR.122047, acetylsalicylsalicylic.acid, ketoprofen, ramifenazone, piroxicam, phenazone",0.0565054840938974,0.00921730819686218,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",-0.23769,-0.574,0.957,610,0.995,"eplerenone, itraconazole, cobicistat, PF.4981517, clotrimazole",0.0190880622231565,0.00217691925427455,FALSE
+"H460","Pearson.est","DNA alkylating agent",-0.49373,-1.19,0.242,1263,0.706,"mitomycin.c, temozolomide, TH.302, estramustine",0.616184634019569,0.151195298948196,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.25266,-0.614,0.931,1188,1,"pibenzimol, bendamustine, primaquine",0.0310503190186574,0,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.43546,-1.05,0.398,669,0.863,"disulfiram, RG108, decitabine, SGI.1027, fdcyd",0.400116927926312,0.0639892042847904,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",-0.52124,-1.25,0.202,1384,0.684,"idoxuridine, trifluridine",0.694648630553376,0.164943898279884,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.22132,-0.533,0.974,670,0.998,"artemisinin, enocitabine, artesunate, azodicarbonamide, CB.10.277, floxuridine, anisomycin, cyclocytidine, capecitabine, mitomycin.c",0.0114410431213845,0.000869458712628891,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",-0.24653,-0.593,0.932,999,0.999,"ziprasidone, sertindole, paliperidone, lurasidone, thioproperazine, piperacetazine, UH.232....",0.0305840876460186,0.000434511774017692,FALSE
+"H460","Pearson.est","estrogen receptor agonist",-0.40463,-0.962,0.547,617,0.865,"erteberel, equol, ethinyl.estradiol, estradiol.cypionate, estrone, estradiol, PPT",0.262012673666569,0.0629838925351858,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",-0.57048,-1.38,0.0911,1444,0.522,"clomifene",1.040481623027,0.282329496997738,FALSE
+"H460","Pearson.est","FGFR inhibitor",-0.67335,-1.61,0.017,1205,0.26,"nintedanib, MK.2461, regorafenib, lucitanib",1.76955107862173,0.585026652029182,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.45728,-1.07,0.38,851,0.833,"gilteritinib, ponatinib, TG.101348, sorafenib, lestaurtinib, TG.02, tozasertib, pacritinib, KW.2449, tandutinib, ENMD.2076",0.42021640338319,0.0793549985932124,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",-0.34231,-0.818,0.733,1034,0.924,"prednisolone.hemisuccinate, fludroxycortide, deflazacort, fluorometholone, fluticasone.propionate, betamethasone, flumethasone, halobetasol.propionate, methylprednisolone, difluprednate, prednisolone",0.134896025358872,0.0343280287798933,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.19512,0.577,0.953,1168,0.953,"MTPG, kynurenic.acid, SIB.1757, felbamate, JNJ.16259685, CGP.37849, latrepirdine, LY456236, diazooxonorleucine, CPP, ACDPP, tiletamine, IEM1754",0.0209070993616736,0.0209070993616736,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",0.42252,1.23,0.178,840,0.492,"CHIR.98014, GSK.3.inhibitor.IX, tideglusib, TWS.119, LY2090314, kenpaullone, indirubin, CHIR.99021, AZD2858",0.749579997691106,0.30803489723264,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.52442,-1.25,0.182,948,0.684,"AZD3463, GW.441756, lestaurtinib, GSK1838705A, danusertib",0.739928612014925,0.164943898279884,FALSE
+"H460","Pearson.est","HCV inhibitor",-0.35834,-0.863,0.666,1224,0.946,"narlaprevir, mericitabine",0.176525770829699,0.0241088635982073,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.49091,-1.2,0.226,1106,0.705,"belinostat, vorinostat, mocetinostat, givinostat, R306465, AR.42, RG2833, M.344, dacinostat, trichostatin.a, resminostat",0.645891560852599,0.151810883008601,FALSE
+"H460","Pearson.est","histamine receptor antagonist",-0.44073,-1.07,0.38,915,0.833,"lafutidine, levocetirizine, ebastine, astemizole, nizatidine, cimetidine, pheniramine, BF2.649, ICI.162846, tiotidine",0.42021640338319,0.0793549985932124,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.53121,1.6,0.0485,682,0.302,"mevastatin, lovastatin, fluvastatin, simvastatin, pitavastatin, atorvastatin",1.31425826139774,0.519993057042849,FALSE
+"H460","Pearson.est","HSP inhibitor",-0.60181,-1.47,0.0596,960,0.406,"tanespimycin, NVP.AUY922, SNX.5422, NMS.E973, alvespimycin, ganetespib, PU.H71, SNX.2112, VER.49009, XL888",1.22475374025976,0.391473966422806,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.64079,-1.56,0.0332,971,0.321,"TG.101348, lestaurtinib, WHI.P154, PRT062070, TG.02, baricitinib, tozasertib, pacritinib, TG.101209, atiprimod, AZD1480, AZ960, filgotinib, AT.9283",1.47886191629596,0.493494967595128,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.42362,-1.02,0.435,835,0.825,"motesanib, pazopanib, KI.8751, cediranib, OSI.930, sorafenib, telatinib, tandutinib, vatalanib, regorafenib",0.361510743045363,0.0835460514500749,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.38018,-0.917,0.598,1082,0.89,"nutlin.3, CGM097",0.223298816011589,0.0506099933550872,FALSE
+"H460","Pearson.est","MEK inhibitor",0.41335,1.23,0.205,192,0.492,"U.0126, MEK162, PD.318088, AZD8330, PD.198306, BIX.02188, PD.184352, refametinib, Ro.4987655, TAK.733",0.688246138944246,0.30803489723264,FALSE
+"H460","Pearson.est","MET inhibitor",-0.34219,-0.83,0.7,1322,0.92,"AMG458",0.154901959985743,0.0362121726544447,FALSE
+"H460","Pearson.est","microtubule inhibitor",-0.48447,-1.17,0.247,861,0.68,"colchicine, podophyllotoxin, triclabendazole, cabazitaxel, cytochalasin.b, vinflunine, secnidazole, D.64131",0.607303046740334,0.167491087293764,FALSE
+"H460","Pearson.est","mTOR inhibitor",0.39162,1.15,0.317,107,0.537,"SB.2343, sirolimus, PP242, WAY.600, OSI.027, deforolimus, torin.1, PF.05212384, temsirolimus",0.498940737782249,0.270025714300444,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",-0.35827,-0.846,0.689,895,0.908,"IKK.2.inhibitor.V, Ro.106.9920, EVP4593, bortezomib, betulinic.acid",0.161780778092374,0.0419141514789149,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.54533,-1.33,0.134,1298,0.553,"salvinorin.a, trimebutine",0.872895201635192,0.257274868695302,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",-0.57544,-1.4,0.0842,1037,0.552,"SB.239063, SB.242235, talmapimod, VX.702",1.07468790850035,0.258060922270801,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.4013,-0.982,0.501,582,0.838,"endo.IWR.1, niraparib, AZD2461, E7449, PJ.34, olaparib, talazoparib",0.300162274132754,0.0767559813697235,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.42323,-1.02,0.454,835,0.825,"motesanib, pazopanib, ponatinib, KI.8751, axitinib, sorafenib, telatinib, trapidil, nintedanib, tandutinib, vatalanib, crenolanib, regorafenib, CP.673451",0.342944147142896,0.0835460514500749,FALSE
+"H460","Pearson.est","phosphatase inhibitor",-0.40721,-0.983,0.498,1044,0.857,"mycophenolic.acid, menadione, GSK2830371, CID.5458317",0.302770657240282,0.0670191780768018,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",0.19533,0.598,0.965,116,1,"anagrelide, zardaverine, enoximone",0.0154726866562074,0,FALSE
+"H460","Pearson.est","PI3K inhibitor",0.2117,0.644,0.875,135,1,"SB.2343, PI.828, PF.05212384, pilaralisib, idelalisib, PI3K.IN.2",0.0579919469776868,0,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.72545,-1.73,0.0078,1296,0.192,"GSK461364, GW.843682X, volasertib, NMS.1286937, BI.2536",2.10790539730952,0.71669877129645,TRUE
+"H460","Pearson.est","potassium channel blocker",-0.24971,-0.605,0.943,921,1,"oleoylethanolamide, mepivacaine",0.0254883072626717,0,FALSE
+"H460","Pearson.est","PPAR receptor agonist",0.47652,1.4,0.15,150,0.43,"pterostilbene, clofibrate, GW.501516",0.823908740944319,0.366531544420413,FALSE
+"H460","Pearson.est","progesterone receptor agonist",0.26016,0.803,0.778,242,1,"tanaproget, norethindrone.acetate, norethindrone, levonorgestrel, norgestrel",0.109020403010311,0,FALSE
+"H460","Pearson.est","proteasome inhibitor",-0.417,-1.02,0.431,725,0.825,"oprozomib, carfilzomib, ixazomib.citrate, MG.132, ixazomib, bortezomib",0.365522729839268,0.0835460514500749,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.35774,-0.868,0.672,1316,0.976,"harringtonine, bruceantin, anguidine, puromycin",0.172630726946175,0.0105501823333082,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.51769,-1.24,0.192,855,0.619,"PP.121, tyrphostin.A9, NVP.TAE226, rheochrysidin, BMS.599626, CP.724714, AV.412",0.71669877129645,0.208309350979882,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.27524,-0.661,0.891,883,0.995,"GDC.0879, sorafenib, RAF265, regorafenib, TAK.632",0.0501222959631252,0.00217691925427455,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.43204,-1.04,0.416,978,0.865,"sorafenib, cabozantinib, regorafenib",0.380906669373257,0.0629838925351858,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.34887,-0.851,0.661,862,0.933,"tamibarotene, AM.580, bexarotene, adarotene",0.17979854051436,0.0301183562535,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.62068,-1.5,0.0414,983,0.373,"hydroxyurea, cladribine, gemcitabine, clofarabine, pentostatin, fludarabine, fludarabine.phosphate",1.3829996588791,0.428291168191312,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.75491,-1.83,0.00342,1359,0.117,"ipsapirone, zolmitriptan, aripiprazole",2.46597389394387,0.931814138253838,TRUE
+"H460","Pearson.est","serotonin receptor antagonist",-0.62547,-1.53,0.0448,999,0.347,"ziprasidone, SB.200646, sertindole, paliperidone, lurasidone, SB.228357, SB.216641, RS.16566, aripiprazole",1.34872198600186,0.459670525209126,FALSE
+"H460","Pearson.est","sodium channel blocker",-0.32528,-0.797,0.759,849,0.926,"triamterene, ajmaline, oxcarbazepine, mepivacaine, cibenzoline, butamben, quinidine",0.11975822410452,0.0333890133180656,FALSE
+"H460","Pearson.est","src inhibitor",-0.4897,-1.17,0.258,1229,0.68,"PP.1, bosutinib, KX2.391",0.58838029403677,0.167491087293764,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.30299,-0.732,0.84,580,0.984,"lanoconazole, terconazole, ketoconazole, chlormidazole, posaconazole",0.0757207139381184,0.00700490156865849,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",-0.41284,-0.99,0.465,899,0.858,"SB.525334, LY2109761, D.4476",0.332547047110046,0.0665127121512946,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.50849,-1.24,0.192,774,0.619,"doxifluridine, ftorafur, raltitrexed, capecitabine, trifluridine",0.71669877129645,0.208309350979882,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.1813,-0.43,0.996,620,0.994,"fleroxacin, idarubicin, mitoxantrone, teniposide, etoposide.phosphate, amsacrine, dexrazoxane, camptothecin, daunorubicin, valrubicin, genz.644282, SN.38, amonafide, exatecan.mesylate, licochalcone.a",0.00174066157630127,0.00261361560268669,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.55238,-1.34,0.115,968,0.56,"epothilone.d, vincristine, verubulin, vindesine, dolastatin.10, vinorelbine, plinabulin, taltobulin, oxibendazole, docetaxel, fosbretabulin, combretastatin.A.4, paclitaxel, epothilone.b, nocodazole, albendazole, parbendazole, KX2.391, ABT.751, flubendazole",0.939302159646388,0.2518119729938,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.48551,-1.18,0.252,855,0.706,"PP.121, tyrphostin.A9, NVP.TAE226, hypericin, rheochrysidin, sorafenib, BMS.599626, cabozantinib, AMG.208, tyrphostin.AG.99, UNC2250, CP.724714, regorafenib, AV.412, tivantinib, aminopurvalanol.a",0.598599459218456,0.151195298948196,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.41568,-1.01,0.447,818,0.83,"AEE788, motesanib, pazopanib, KI.8751, cediranib, axitinib, OSI.930, sorafenib, TG.100572, cabozantinib, telatinib, RAF265, XL.647, tivozanib, nintedanib, foretinib, vatalanib, MK.2461, regorafenib, golvatinib, lucitanib, ENMD.2076",0.349692476868064,0.0809219076239261,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",-0.71279,-1.71,0.00896,1136,0.169,"alfacalcidol, doxercalciferol, tacalcitol",2.04769199033787,0.772113295386326,TRUE
+"A549","Pearson.est","EGFR inhibitor",0.30611,0.805,0.665,242,0.825,"dacomitinib, GW.583340, pelitinib, poziotinib, ARRY.334543, tucatinib, AST.1306, WZ.3146, AZD8931, FERb.033",0.177178354696895,0.0835460514500749,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",0.45329,1.21,0.247,333,0.851,"ZM.306416, ponatinib, nilotinib, dasatinib, flumatinib, imatinib",0.607303046740334,0.0700704399154121,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",-0.66967,-1.69,0.0255,997,0.387,"tremorine, xanomeline, nefiracetam, nicotine",1.59345981956604,0.412289034981089,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",-0.40461,-1.02,0.416,1180,0.815,"dicycloverine, darifenacin",0.380906669373257,0.0888423912600234,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.4381,1.14,0.286,7,0.766,"theophylline",0.543633966870957,0.115771230367396,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",-0.36432,-0.921,0.531,1215,0.796,"clenbuterol, oxymetazoline, isoxsuprine, metaraminol",0.274905478918531,0.0990869322623309,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",-0.24087,-0.607,0.906,1309,0.937,"levobunolol, practolol, dronedarone",0.0428718023231869,0.0282604091122217,FALSE
+"A549","Pearson.est","AKT inhibitor",0.37003,0.951,0.487,267,0.869,"CCT128930, AT7867, GSK2110183, A.674563",0.312471038785366,0.0609802235513335,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41726,-1.02,0.437,1017,0.815,"lorlatinib, SB.505124, crizotinib, GW.788388, DMH1, CEP.37440",0.359518563029578,0.0888423912600234,FALSE
+"A549","Pearson.est","androgen receptor antagonist",-0.46564,-1.15,0.303,1434,0.686,"enzalutamide",0.518557371497695,0.163675884293248,FALSE
+"A549","Pearson.est","antioxidant",0.40835,1.06,0.335,254,0.799,"taurine, trolox",0.474955192963155,0.0974532206860086,FALSE
+"A549","Pearson.est","AP inhibitor",0.51824,1.34,0.163,199,0.766,"LCL.161, embelin",0.787812395596042,0.115771230367396,FALSE
+"A549","Pearson.est","ATPase inhibitor",-0.64954,-1.64,0.0438,1351,0.395,"oligomycin.a, rabeprazole, omeprazole, thonzonium",1.3585258894959,0.40340290437354,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.56388,-1.37,0.129,1003,0.607,"MK.8745, GSK1070916, MLN.8054, MK.5108, ZM.447439, SNS.314, KW.2449, AT.9283, danusertib, CCT137690, alisertib, AMG900, barasertib, hesperadin, TAK.901, tozasertib",0.889410289700751,0.216811308924742,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.44815,1.16,0.26,223,0.776,"josamycin, azithromycin, dirithromycin",0.585026652029182,0.110138278741812,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.19626,0.507,0.973,522,1,"lomefloxacin, sparfloxacin, norfloxacin, novobiocin, trovafloxacin",0.0118871597316481,0,FALSE
+"A549","Pearson.est","BCL inhibitor",-0.45453,-1.12,0.327,1401,0.68,"gossypol, HA14.1",0.485452247339714,0.167491087293764,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.45059,1.2,0.248,333,0.802,"ponatinib, nilotinib, dasatinib, flumatinib, imatinib",0.605548319173784,0.0958256317158365,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",-0.50266,-1.23,0.225,1121,0.592,"ivermectin, CL.218872, piperazine, indiplon, ZK.93423, nefiracetam",0.647817481888638,0.22767829327708,FALSE
+"A549","Pearson.est","bromodomain inhibitor",0.33495,0.866,0.584,965,0.829,"PFI.1, I.BET.762, I.BET151, JQ1...., bromosporine, OTX015",0.233587152887601,0.0814454694497265,FALSE
+"A549","Pearson.est","calcium channel blocker",-0.55059,-1.38,0.14,1316,0.647,"penfluridol, tetrandrine, efonidipine.monoethanolate, SKF.96365",0.853871964321762,0.1890957193313,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",0.3741,0.979,0.469,404,0.85,"MK.0812, UNBS.5162, RS.504393, SB.225002",0.328827157284917,0.0705810742857073,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.37535,-0.93,0.535,954,0.835,"aminopurvalanol.a, abemaciclib, BMS.387032, BMS.265246, R547, palbociclib, PHA.848125, TG.02, indisulam, PHA.793887, JNJ.7706621, AZD5438",0.271646217978772,0.0783135245163979,FALSE
+"A549","Pearson.est","CHK inhibitor",-0.48819,-1.24,0.23,1076,0.611,"LY2606368, LY2603618, AZD7762, SCH.900776, CHIR.124",0.638272163982407,0.213958789757446,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",0.43137,1.11,0.358,248,0.736,"AM.404, FK.3311, pterostilbene, sulfasalazine, piroxicam, metoxibutropate",0.446116973356126,0.133122185662501,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",-0.41127,-1.01,0.438,1428,0.801,"itraconazole",0.3585258894959,0.0963674839157623,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.2195,-0.545,0.949,1177,0.959,"temozolomide, cyclophosphamide, carmustine",0.0227337875727074,0.0181813928293364,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.25959,-0.632,0.886,860,0.959,"nithiamide, sangivamycin, valrubicin, primaquine, tirapazamine, busulfan, metronidazole, nimorazole, pibenzimol, carmustine",0.0525662781129492,0.0181813928293364,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.51433,1.35,0.177,4,1,"RG108",0.752026733638193,0,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",-0.31664,-0.796,0.7,916,0.885,"cephalomannine, adefovir.dipivoxil, foscarnet, menadione, famciclovir",0.154901959985743,0.0530567293021746,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",0.34498,0.884,0.569,233,0.927,"capecitabine, enocitabine, estramustine.phosphate, CB.10.277, cisplatin",0.244887733604929,0.0329202658555029,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",-0.38066,-0.951,0.529,1224,0.855,"thioproperazine, isofloxythepin, mesoridazine, clebopride",0.276544327964814,0.0680338852718274,FALSE
+"A549","Pearson.est","estrogen receptor agonist",0.34211,0.882,0.6,311,0.859,"equol, PPT, estradiol.cypionate, estrone",0.221848749616356,0.0660068361687577,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.50153,1.3,0.183,409,0.775,"danazol, tamoxifen, toremifene, clomifene",0.737548910269571,0.11069829749369,FALSE
+"A549","Pearson.est","FGFR inhibitor",0.31553,0.842,0.623,190,0.843,"orantinib, lenvatinib, regorafenib",0.20551195334083,0.0741724253752577,FALSE
+"A549","Pearson.est","FLT3 inhibitor",-0.3551,-0.863,0.617,1095,0.82,"KW.2449, TG.02, tandutinib, gilteritinib, TG.101348, pacritinib, sunitinib, tozasertib",0.209714835966758,0.0861861476162833,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.26856,-0.658,0.859,987,0.954,"difluprednate, prednisolone.acetate, flumethasone, prednisolone, halobetasol.propionate, prednisolone.hemisuccinate, dexamethasone.acetate, hydrocortisone",0.0660068361687577,0.0204516252959049,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.3109,0.809,0.672,292,0.846,"LY456236, CGP.37849, tiletamine, MTPG, CPP",0.172630726946175,0.0726296369609765,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.4678,-1.14,0.318,1141,0.672,"LY2090314, CHIR.98014, GSK.3.inhibitor.IX, AZD2858",0.497572880015567,0.172630726946175,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",0.43209,1.12,0.313,30,0.761,"GW.441756",0.504455662453552,0.118615343229427,FALSE
+"A549","Pearson.est","HCV inhibitor",0.33282,0.866,0.603,199,0.829,"narlaprevir, embelin",0.219682687859849,0.0814454694497265,FALSE
+"A549","Pearson.est","HDAC inhibitor",-0.34878,-0.871,0.588,1053,0.832,"dacinostat, scriptaid, romidepsin, vorinostat, JNJ.26481585, RG2833, PCI.24781, M.344, AR.42, pyroxamide, R306465",0.230622673923862,0.0798766737092761,FALSE
+"A549","Pearson.est","histamine receptor antagonist",-0.24886,-0.61,0.917,1229,0.957,"terfenadine, famotidine, chloropyramine, levocetirizine, ranitidine",0.0376306643299789,0.0190880622231565,FALSE
+"A549","Pearson.est","HMGCR inhibitor",-0.59454,-1.46,0.0936,896,0.592,"simvastatin, mevastatin, fluvastatin, pitavastatin, lovastatin",1.02872415126189,0.22767829327708,FALSE
+"A549","Pearson.est","HSP inhibitor",-0.3009,-0.75,0.772,942,0.883,"BIIB021, tanespimycin, NVP.AUY922, SNX.2112, guanidine, KW.2478",0.112382699664264,0.0540392964224314,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.34303,-0.841,0.665,1107,0.834,"TG.02, AT.9283, AZ960, TG.101348, pacritinib, tozasertib",0.177178354696895,0.0788339493622613,FALSE
+"A549","Pearson.est","KIT inhibitor",0.26784,0.722,0.818,252,0.905,"cediranib, lenvatinib, regorafenib, dasatinib, masitinib",0.087246696328677,0.0433514207947967,FALSE
+"A549","Pearson.est","MDM inhibitor",0.6705,1.71,0.042,355,0.462,"idasanutlin, AMG.232, CGM097, serdemetan",1.3767507096021,0.335358024443874,FALSE
+"A549","Pearson.est","MEK inhibitor",-0.37851,-0.932,0.537,1221,0.862,"MEK162, PD.184352, AZD8330, refametinib, cobimetinib",0.270025714300444,0.0644927341752872,FALSE
+"A549","Pearson.est","MET inhibitor",-0.76595,-1.91,0.00176,1147,0.176,"PHA.665752, LY2801653, NVP.BVU972, PF.04217903, INC.280",2.75448733218585,0.75448733218585,TRUE
+"A549","Pearson.est","microtubule inhibitor",0.39159,1.02,0.4,109,0.844,"podophyllotoxin, estramustine.phosphate",0.397940008672038,0.073657553374345,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.38425,-0.964,0.483,1218,0.861,"PF.04691502, SB.2343, GSK2126458, PF.05212384, PP242, WYE.354, torin.2, OSI.027",0.316052869248488,0.0649968485463452,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",-0.62379,-1.54,0.0687,1155,0.468,"IKK.2.inhibitor.V, curcumin, tyloxapol, BAY.11.7085, Ro.106.9920, betulinic.acid, bortezomib",1.16304326294045,0.329754146925876,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.37377,-0.926,0.534,1176,0.814,"trimebutine, BW.180C",0.272458742971444,0.0893755951107988,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",-0.31705,-0.783,0.719,1422,0.857,"TAK.715",0.143271109617117,0.0670191780768018,FALSE
+"A549","Pearson.est","PARP inhibitor",0.38736,1.01,0.427,117,0.824,"E7449, AG.14361",0.369572124974976,0.0840727883028842,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.24307,0.638,0.88,258,0.937,"ponatinib, orantinib, lenvatinib, regorafenib, dasatinib, masitinib, axitinib",0.0555173278498314,0.0282604091122217,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.32076,-0.794,0.721,1092,0.864,"mycophenolic.acid, menadione, alexidine",0.142064735280571,0.0634862575211067,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",0.45195,1.19,0.243,44,0.762,"cilostamide, trequinsin",0.614393726401688,0.1180450286604,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.48773,-1.22,0.219,1211,0.578,"GDC.0941, PF.04691502, PI.828, SB.2343, GSK2126458, PF.05212384, PIK.75, pilaralisib, CUDC.907, TG100.115, CH5132799",0.659555885159882,0.238072161579471,FALSE
+"A549","Pearson.est","PLK inhibitor",0.26944,0.694,0.809,67,0.919,"GSK461364",0.0920514783877277,0.0366844886138887,FALSE
+"A549","Pearson.est","potassium channel blocker",-0.53722,-1.35,0.153,1261,0.597,"ML133, meglitinide",0.815308569182401,0.224025668870631,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.35168,0.904,0.53,169,0.926,"fenofibrate, pterostilbene",0.275724130399211,0.0333890133180656,FALSE
+"A549","Pearson.est","progesterone receptor agonist",0.29375,0.76,0.732,288,0.872,"danazol, norethindrone, norgestrel",0.135488918941608,0.0594835150674328,FALSE
+"A549","Pearson.est","proteasome inhibitor",-0.66303,-1.63,0.0504,1091,0.337,"MG.132, ixazomib.citrate, ixazomib, carfilzomib, oprozomib, bortezomib",1.29756946355447,0.472370099128661,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",0.17889,0.457,0.993,486,0.992,"emetine, clindamycin.phosphate, harringtonine, mercaptopurine, bruceantin, cycloheximide, anguidine",0.00305075150461883,0.00348832784582135,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.52229,-1.31,0.205,1313,0.589,"tyrphostin.A9, mubritinib, BMS.599626",0.688246138944246,0.229884705212898,FALSE
+"A549","Pearson.est","RAF inhibitor",0.34281,0.883,0.574,291,0.892,"CEP.32496, AZ.628, PLX.4720, regorafenib, TAK.632",0.241088107602027,0.0496351456238769,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.53013,-1.31,0.178,1377,0.589,"apatinib, sunitinib",0.749579997691106,0.229884705212898,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.7253,1.88,0.00959,132,0.454,"adarotene, LE.135, adapalene",2.01818139282934,0.342944147142896,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",0.45126,1.21,0.234,274,0.851,"fludarabine.phosphate, hydroxyurea, cytarabine",0.630784142589857,0.0700704399154121,FALSE
+"A549","Pearson.est","serotonin receptor agonist",-0.74424,-1.83,0.0102,1447,0.198,"aripiprazole",1.99139982823808,0.703334809738469,TRUE
+"A549","Pearson.est","serotonin receptor antagonist",-0.5041,-1.26,0.198,1279,0.609,"lerisetron, RS.16566, aripiprazole",0.703334809738469,0.215382707367125,FALSE
+"A549","Pearson.est","sodium channel blocker",-0.58258,-1.42,0.11,1120,0.619,"ajmaline, lappaconite, mexiletine, butamben, benzethonium, benzocaine",0.958607314841775,0.208309350979882,FALSE
+"A549","Pearson.est","src inhibitor",0.51367,1.34,0.158,252,0.766,"ZM.306416, KX2.391, dasatinib, masitinib",0.801342913045577,0.115771230367396,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",0.55375,1.43,0.122,415,1,"ketoconazole, chlormidazole, terconazole",0.913640169325252,0,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",-0.50925,-1.26,0.203,925,0.609,"SB.431542, D.4476, adaprev, repsox, SB.525334",0.692503962086787,0.215382707367125,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",0.68924,1.83,0.0191,98,0.326,"capecitabine, doxifluridine",1.71896663275227,0.486782399932061,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.28179,-0.691,0.816,905,0.938,"genz.644282, valrubicin, voreloxin, camptothecin, teniposide, topotecan, dexrazoxane, irinotecan, doxorubicin, rubitecan, SN.38",0.0883098412461389,0.0277971616209356,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",0.51935,1.34,0.152,295,0.766,"dolastatin.10, combretastatin.A.4, podophyllotoxin, vincristine, taltobulin, KX2.391, CYT.997, fenbendazole, ABT.751, plinabulin, parbendazole, verubulin, vinorelbine",0.818156412055227,0.115771230367396,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",-0.36191,-0.885,0.583,1313,0.835,"tyrphostin.A9, apatinib, mubritinib, sunitinib, BMS.599626",0.234331445240986,0.0783135245163979,FALSE
+"A549","Pearson.est","VEGFR inhibitor",0.26271,0.679,0.853,190,0.914,"ZM.306416, SAR131675, semaxanib, orantinib, cediranib, lenvatinib, ENMD.2076, regorafenib",0.069050968832477,0.0390538042661686,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",0.31275,0.822,0.651,15,0.851,"doxercalciferol",0.186419011431808,0.0700704399154121,FALSE
+"HCC44","Pearson.est","EGFR inhibitor",-0.15057,-0.362,1,1116,0.999,"CNX.2006, WZ8040, WZ.4002, tyrphostin.AG.494, tyrphostin.AG.1478, BIBX.1382, rociletinib",0,0.000434511774017692,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",-0.50753,-1.22,0.234,1356,0.608,"bosutinib, tozasertib, KW.2449",0.630784142589857,0.216096420727265,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",-0.57698,-1.37,0.129,832,0.589,"nefiracetam, tremorine, oxiracetam, xanomeline, nicotine, pilocarpine",0.889410289700751,0.229884705212898,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.37489,-0.899,0.601,966,0.888,"dicycloverine, methscopolamine, iododexetimide",0.22112552799726,0.051587034221399,FALSE
+"HCC44","Pearson.est","adenosine receptor antagonist",0.43932,1.29,0.194,93,0.403,"PSB.1115, CGS.15943",0.712198270069774,0.39469495385889,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.29195,-0.703,0.851,1158,0.944,"epinephrine, xylazine, isoetharine, norepinephrine",0.0700704399154121,0.025028005701931,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",-0.23199,-0.56,0.956,806,1,"oxprenolol, carvedilol, idazoxan, metoprolol, pindolol, levobunolol, vincamine, imiloxan, naftidrofuryl",0.0195421077238999,0,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.36152,-0.854,0.641,737,0.932,"triciribine, AZD5363, GSK2110183, A.674563, uprosertib, palomid.529, CCT128930, ONC201, AT7867",0.193141970481183,0.0305840876460186,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26653,0.773,0.738,1065,0.812,"NVP.TAE684, GW.788388, CEP.37440, SB.505124, brigatinib, crizotinib, DMH1, lorlatinib, AZD3463, AP26113, alectinib",0.131943638176958,0.0904439707588247,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",-0.5123,-1.25,0.184,1024,0.587,"RU.58841, flutamide, nilutamide, bicalutamide",0.735182176990464,0.231361898752386,FALSE
+"HCC44","Pearson.est","antioxidant",-0.54993,-1.33,0.145,793,0.536,"taurine, rutin, mesna, benfotiamine, trolox, chlorogenic.acid",0.838631997765025,0.27083521030723,FALSE
+"HCC44","Pearson.est","AP inhibitor",0.59577,1.68,0.0561,150,0.443,"tanshinone.i, birinapant, embelin",1.25103713874384,0.35359627377693,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",-0.42329,-1.03,0.421,1160,0.788,"oligomycin.a, rabeprazole, digitoxigenin, digitoxin",0.375717904164332,0.103473782510445,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.77635,-1.9,0.00125,1208,0.114,"ZM.447439, PHA.680632, alisertib, danusertib, barasertib.HQPA, TAK.901, MK.8745, GSK1070916, CCT129202, barasertib, CCT137690, tozasertib, SNS.314, KW.2449, AMG900, CYC116, PF.03814735, AT.9283, hesperadin",2.90308998699194,0.943095148663527,TRUE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.24267,-0.582,0.931,756,1,"azalomycin.b, josamycin, radezolid, tilmicosin, valnemulin",0.0310503190186574,0,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.3727,-0.893,0.613,1291,0.88,"norfloxacin, finafloxacin",0.212539525481585,0.0555173278498314,FALSE
+"HCC44","Pearson.est","BCL inhibitor",-0.41204,-0.99,0.479,1301,0.789,"venetoclax, TW.37",0.319664486585437,0.10292299679058,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.41447,-0.992,0.474,1356,0.806,"bosutinib, tozasertib",0.324221658325915,0.0936649581949093,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",0.2672,0.773,0.737,188,0.812,"gamma.aminobutyric.acid, CL.218872, indiplon, ZK.93423, temazepam",0.132532512140949,0.0904439707588247,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",-0.63731,-1.53,0.0551,919,0.409,"PFI.1, I.BET.762, OTX015, I.BET151, JQ1...., bromosporine",1.25884840114821,0.388276691992658,FALSE
+"HCC44","Pearson.est","calcium channel blocker",0.46495,1.32,0.188,44,0.413,"fendiline, SKF.96365, efonidipine.monoethanolate",0.72584215073632,0.384049948343599,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",0.30412,0.875,0.575,136,0.769,"ZK811752, UNBS.5162",0.24033215531037,0.114073660198569,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.43104,-1.04,0.425,945,0.79,"TG.02, abemaciclib, AZD5438, palbociclib, PHA.793887, indisulam, PHA.848125, R547, aminopurvalanol.a, BMS.265246",0.371611069949688,0.102372908709559,FALSE
+"HCC44","Pearson.est","CHK inhibitor",-0.45814,-1.1,0.362,1104,0.72,"LY2606368, LY2603618, SB.218078",0.441291429466834,0.142667503568732,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.43785,-1.06,0.427,1020,0.768,"tepoxalin, curcumin, naproxen, aspirin, meloxicam, amfenac, FR.122047, ketoprofen, piroxicam",0.369572124974976,0.114638779968488,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.32511,-0.759,0.78,912,0.963,"clotrimazole, PF.4981517, eplerenone, cobicistat",0.10790539730952,0.0163737128754655,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",-0.46814,-1.12,0.318,1396,0.699,"carboplatin, streptozotocin, cyclophosphamide",0.497572880015567,0.155522824254319,FALSE
+"HCC44","Pearson.est","DNA inhibitor",0.16281,0.466,1,173,0.994,"carmustine, bendamustine, sangivamycin",0,0.00261361560268669,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",0.41132,1.19,0.238,239,0.503,"azacitidine, fdcyd, SGI.1027",0.623423042943488,0.298432014944073,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.52587,-1.25,0.199,1015,0.587,"famciclovir, idoxuridine, menadione, cephalomannine",0.701146923590293,0.231361898752386,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",-0.48238,-1.15,0.315,1217,0.652,"anisomycin, artemisinin, altretamine, CB.10.277, artesunate",0.501689446210399,0.18575240426808,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.50287,-1.2,0.266,1090,0.606,"amisulpride, remoxipride, oxiperomide, piperacetazine, raclopride, UH.232...., thioproperazine",0.575118363368933,0.217527375833714,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",-0.53981,-1.29,0.165,1221,0.608,"estrone, estradiol.cypionate, ethinyl.estradiol, PPT",0.782516055786094,0.216096420727265,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",-0.33336,-0.812,0.718,1303,0.922,"clomifene",0.1438755557577,0.0352690789463706,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",0.4865,1.4,0.104,77,0.363,"erdafitinib, dovitinib, PD.173074",0.98296666070122,0.440093374963888,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.38171,-0.921,0.568,1032,0.865,"tyrphostin.AG.1296, lestaurtinib, quizartinib, TG.101348, pacritinib, tozasertib, KW.2449",0.245651664288981,0.0629838925351858,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.6542,-1.59,0.0335,973,0.378,"fludroxycortide, halobetasol.propionate, triamcinolone, prednisolone.hemisuccinate, betamethasone, fluorometholone, difluprednate, flumethasone, clobetasol.propionate, flumethasone.pivalate, rimexolone, deflazacort, halcinonide, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, desonide, hydrocortisone, dexamethasone.acetate, methylprednisolone, ciclesonide, fluocinolone.acetonide, prednisolone",1.47495519296315,0.422508200162775,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",-0.35182,-0.843,0.665,1275,0.93,"SIB.1757, latrepirdine, tiletamine",0.177178354696895,0.0315170514460649,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",0.26268,0.759,0.773,1070,0.793,"CHIR.98014, GSK.3.inhibitor.IX, CHIR.99021, indirubin, kenpaullone, tideglusib, LY2090314, TWS.119, AZD2858",0.111820506081675,0.100726812682396,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.49715,-1.19,0.268,917,0.605,"AZD3463, lestaurtinib, PHA.848125, danusertib",0.571865205971211,0.218244625347531,FALSE
+"HCC44","Pearson.est","HCV inhibitor",-0.53316,-1.27,0.173,1306,0.626,"PSI.7976, narlaprevir",0.761953896871205,0.20342566678957,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",-0.43684,-1.07,0.388,994,0.768,"PCI.24781, romidepsin, SB.939, belinostat, mocetinostat, RG2833, M.344, dacinostat, givinostat, vorinostat, trichostatin.a, AR.42, ACY.1215",0.411168274405793,0.114638779968488,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",-0.55757,-1.33,0.138,1095,0.536,"lafutidine, tiotidine, BF2.649, pheniramine, nizatidine, terfenadine, ICI.162846, famotidine",0.860120913598763,0.27083521030723,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",-0.60765,-1.43,0.0798,1202,0.573,"fluvastatin, pitavastatin",1.09799710864927,0.24184537803261,FALSE
+"HCC44","Pearson.est","HSP inhibitor",-0.58272,-1.4,0.114,934,0.608,"SNX.5422, alvespimycin, PU.H71, XL888, NVP.AUY922, SNX.2112, ganetespib, BIIB021, VER.49009, tanespimycin",0.943095148663527,0.216096420727265,FALSE
+"HCC44","Pearson.est","JAK inhibitor",-0.60705,-1.46,0.0832,1075,0.552,"lestaurtinib, filgotinib, AZ960, TG.101348, PRT062070, WHI.P154, pacritinib, TG.101209, tozasertib, AT.9283",1.07987667370928,0.258060922270801,FALSE
+"HCC44","Pearson.est","KIT inhibitor",-0.16966,-0.411,0.999,679,1,"regorafenib, cediranib, midostaurin, KI.8751, tandutinib, masitinib, imatinib, telatinib, vatalanib",0.000434511774017692,0,FALSE
+"HCC44","Pearson.est","MDM inhibitor",-0.76634,-1.86,0.00369,1182,0.0913,"AMG.232, nutlin.3, idasanutlin, RITA, CGM097",2.43297363384094,1.0395292224657,TRUE
+"HCC44","Pearson.est","MEK inhibitor",-0.19453,-0.471,0.987,890,1,"PD.0325901, PD.98059, PD.198306, PD.184352, refametinib, nobiletin",0.00568284733036327,0,FALSE
+"HCC44","Pearson.est","MET inhibitor",0.5199,1.5,0.0718,283,0.436,"INC.280, NVP.BVU972, LY2801653, AMG458",1.1438755557577,0.360513510731414,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",-0.52587,-1.26,0.198,916,0.621,"cytochalasin.b, podophyllotoxin, vinblastine, secnidazole, cabazitaxel, colchicine, D.64131",0.703334809738469,0.20690839982342,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",0.36846,1.08,0.324,312,0.635,"temsirolimus, PF.05212384, OSI.027, everolimus, deforolimus, GSK2126458, torin.2, AZD2014, XL388, voxtalisib, WAY.600, LY3023414, sirolimus, AZD8055",0.489454989793388,0.197226274708024,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",-0.31148,-0.738,0.807,765,0.973,"EVP4593, IKK.2.inhibitor.V, parthenolide, BAY.11.7085, curcumin, betulinic.acid",0.0931264652779296,0.0118871597316481,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.5038,-1.2,0.23,961,0.606,"ADL5859, BW.180C, trimebutine, salvinorin.a",0.638272163982407,0.217527375833714,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",-0.5311,-1.24,0.228,1346,0.585,"CMPD.1, VX.702",0.642065152999546,0.23284413391782,FALSE
+"HCC44","Pearson.est","PARP inhibitor",-0.42984,-1.01,0.456,852,0.789,"AZD2461, E7449, endo.IWR.1, talazoparib, AG.14361, niraparib",0.341035157335565,0.10292299679058,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30518,-0.72,0.819,1040,0.96,"CP.673451, imatinib, telatinib, trapidil, nintedanib, crenolanib, axitinib, vatalanib",0.0867160982395816,0.0177287669604316,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",-0.48369,-1.15,0.303,1270,0.652,"menadione, CID.5458317, bis.maltolato.oxovanadium.IV.",0.518557371497695,0.18575240426808,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.27053,-0.642,0.901,1409,0.991,"GSK256066",0.045275209020937,0.00392634551472468,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",0.35325,1,0.419,127,0.678,"CH5132799, BGT226, PI.828, PF.05212384, buparlisib, PI3K.IN.2, idelalisib, TG100.115",0.377785977033705,0.168770306132937,FALSE
+"HCC44","Pearson.est","PLK inhibitor",-0.56493,-1.33,0.151,1114,0.536,"HMN.214, BI.2536, rigosertib, GSK461364",0.821023052706831,0.27083521030723,FALSE
+"HCC44","Pearson.est","potassium channel blocker",0.32004,0.904,0.542,121,0.816,"dofetilide, ML133",0.266000713461613,0.0883098412461389,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",0.34074,1.02,0.419,957,0.693,"pterostilbene, GW.501516, S26948, clofibrate, oleoylethanolamide, ciprofibrate, fenofibrate",0.377785977033705,0.159266765388193,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",-0.30287,-0.731,0.809,942,0.964,"melengestrol.acetate, nomegestrol.acetate, norgestrel, norethindrone",0.0920514783877277,0.0159229660971692,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",-0.66369,-1.58,0.0321,1309,0.338,"ixazomib.citrate, ixazomib",1.49349496759513,0.471083299722345,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",-0.39729,-0.954,0.536,1292,0.842,"bruceantin, emetine, anguidine, cycloheximide, mercaptopurine",0.27083521030723,0.0746879085003505,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.29837,-0.706,0.846,726,0.958,"NVP.TAE226, tyrphostin.A9, rheochrysidin, CP.724714, AV.412, PP.121",0.0726296369609765,0.0186344909214556,FALSE
+"HCC44","Pearson.est","RAF inhibitor",0.48559,1.42,0.153,76,0.393,"dabrafenib, vemurafenib, GDC.0879",0.815308569182401,0.405607449624573,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.53259,1.52,0.0833,680,0.539,"apatinib, sorafenib, vandetanib, sunitinib, cabozantinib, regorafenib",1.07935499859321,0.268411234813261,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",0.69273,2.04,0.0151,271,0.217,"tamibarotene, adarotene, fenretinide, CD.437, LE.135",1.82102305270683,0.66354026615147,TRUE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.3451,-0.818,0.704,759,0.953,"pentostatin, hydroxyurea, gemcitabine, fludarabine.phosphate, clofarabine, fludarabine",0.152427340857888,0.0209070993616736,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.66901,-1.6,0.0248,1447,0.437,"aripiprazole",1.60554831917378,0.359518563029578,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.55731,-1.36,0.12,1334,0.571,"RS.16566, aripiprazole",0.920818753952375,0.243363891754152,FALSE
+"HCC44","Pearson.est","sodium channel blocker",-0.22514,-0.542,0.969,809,1,"triamterene, oxcarbazepine, A.803467, ajmaline, quinidine, butamben",0.0136762229492347,0,FALSE
+"HCC44","Pearson.est","src inhibitor",-0.39388,-0.937,0.569,1356,0.855,"bosutinib, KX2.391",0.244887733604929,0.0680338852718274,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",-0.68037,-1.63,0.0303,1375,0.469,"ketoconazole, terconazole",1.5185573714977,0.328827157284917,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.34333,-0.814,0.721,1353,0.938,"D.4476",0.142064735280571,0.0277971616209356,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",0.5111,1.44,0.103,711,0.437,"doxifluridine, capecitabine, raltitrexed, trifluridine, ftorafur, carmofur",0.987162775294828,0.359518563029578,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",-0.42232,-1.02,0.434,1073,0.789,"amsacrine, valrubicin, idarubicin, licochalcone.a, teniposide, TAS.103, voreloxin, amonafide",0.362510270487489,0.10292299679058,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.5844,-1.39,0.0847,905,0.581,"indibulin, oxibendazole, CYT.997, vinorelbine, podophyllotoxin, BNC105, dolastatin.10, docetaxel, parbendazole, vinblastine, albendazole, taltobulin, verubulin, plinabulin, combretastatin.A.4, flubendazole, ABT.751, nocodazole, KX2.391, epothilone.b, fosbretabulin, epothilone.d",1.07211658966929,0.235823867609669,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.31447,-0.762,0.779,1329,0.979,"aminopurvalanol.a, tyrphostin.AG.99, UNC2250",0.108462542327436,0.00921730819686218,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",0.29217,0.84,0.607,77,0.786,"TG.100572, pazopanib, dovitinib, foretinib, PD.173074",0.216811308924742,0.104577453960592,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",0.30837,0.895,0.567,33,0.782,"maxacalcitol",0.246416941107093,0.106793246940152,FALSE
+"H1703","Pearson.est","EGFR inhibitor",-0.29748,-0.728,0.796,796,0.856,"icotinib, neratinib, poziotinib, vandetanib, CP.724714, lapatinib, pelitinib, OSI.420, gefitinib, XL.647, TAK.285, canertinib, CGP.52411, GW.583340, AEE788, CNX.2006, PD.153035, rociletinib, WZ8040, ARRY.334543, salvianolic.acid.B, BIBX.1382, PD.168393, WZ.4002",0.0990869322623309,0.0675262353228468,FALSE
+"H1703","Pearson.est","Abl kinase inhibitor",-0.4933,-1.23,0.234,763,0.505,"bafetinib, ponatinib, GZD824, nilotinib, ZM.306416, metatinib, flumatinib, KW.2449, bosutinib, imatinib, tozasertib",0.630784142589857,0.296708621881339,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",0.24549,0.683,0.851,1094,0.943,"pilocarpine, nefiracetam, xanomeline, nicotine, oxiracetam, tremorine",0.0700704399154121,0.0254883072626717,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",0.66385,1.84,0.0222,349,0.211,"hyoscyamine, diphemanil, dicycloverine, methscopolamine, darifenacin",1.65364702554936,0.675717544702307,TRUE
+"H1703","Pearson.est","adenosine receptor antagonist",0.41671,1.14,0.29,74,0.722,"SCH.58261, PSB.1115",0.537602002101044,0.141462802430361,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",0.47441,1.37,0.153,348,0.426,"methyldopa, ritodrine, clenbuterol, norepinephrine, A61603, metaraminol, buphenine, terbutaline",0.815308569182401,0.370590400897281,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",0.27866,0.802,0.664,20,0.836,"propranolol, atenolol....",0.177831920631982,0.0777937225609836,FALSE
+"H1703","Pearson.est","AKT inhibitor",-0.45839,-1.15,0.294,1012,0.567,"triciribine, uprosertib, A.674563, AZD5363, ONC201, CCT128930, AT7867",0.531652669587843,0.246416941107093,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34833,-0.872,0.622,1166,0.735,"crizotinib, AP26113, AZD3463",0.206209615309181,0.133712660915805,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",0.52448,1.45,0.0841,357,0.496,"bicalutamide, RU.58841, enzalutamide, cyproterone.acetate",1.07520400420209,0.304518323509803,FALSE
+"H1703","Pearson.est","antioxidant",-0.54797,-1.35,0.149,969,0.467,"benfotiamine, chlorogenic.acid, mesna, rutin, trolox",0.826813731587726,0.330683119433888,FALSE
+"H1703","Pearson.est","AP inhibitor",0.62259,1.73,0.0645,70,0.252,"GDC.0152, tanshinone.i, birinapant",1.19044028536473,0.598599459218456,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.44219,-1.08,0.365,788,0.595,"digitoxigenin, thonzonium, rabeprazole, blebbistatin...., digitoxin, oligomycin.a, digoxin, omeprazole",0.437707135543525,0.22548303427145,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.62915,-1.57,0.0499,951,0.379,"PHA.680632, CCT137690, MK.5108, KW.2449, GSK1070916, ZM.447439, barasertib, PF.03814735, MK.8745, alisertib, AMG900, danusertib, SNS.314, CCT129202, tozasertib, hesperadin, AT.9283, TAK.901, CYC116",1.30189945437661,0.421360790031928,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42587,-1.05,0.394,1311,0.595,"azalomycin.b, valnemulin",0.404503778174426,0.22548303427145,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.66432,1.92,0.0128,277,0.427,"trovafloxacin, lomefloxacin, sarafloxacin, sparfloxacin, nadifloxacin, finafloxacin",1.89279003035213,0.369572124974976,FALSE
+"H1703","Pearson.est","BCL inhibitor",-0.48724,-1.23,0.245,867,0.505,"TW.37, venetoclax, obatoclax, ABT.737, gossypol",0.610833915635468,0.296708621881339,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",-0.48607,-1.19,0.275,763,0.534,"bafetinib, ponatinib, GZD824, nilotinib, metatinib, flumatinib, bosutinib, imatinib, tozasertib",0.560667306169737,0.272458742971444,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.55781,1.51,0.0805,202,0.483,"gamma.aminobutyric.acid, bentazepam, piperazine, eprinomectin, temazepam, CL.218872",1.09420411963213,0.316052869248488,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",-0.55414,-1.38,0.118,956,0.536,"JQ1...., OTX015, PFI.1, bromosporine",0.928117992693875,0.27083521030723,FALSE
+"H1703","Pearson.est","calcium channel blocker",0.31123,0.878,0.598,105,0.775,"efonidipine.monoethanolate, SKF.96365",0.223298816011589,0.11069829749369,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",0.31031,0.892,0.574,369,0.788,"ZK811752, RS.504393, PF.04136309, UNBS.5162",0.241088107602027,0.103473782510445,FALSE
+"H1703","Pearson.est","CDK inhibitor",-0.62042,-1.57,0.0464,1279,0.379,"dinaciclib, JNJ.7706621, AT.7519, arcyriaflavin.a, PHA.793887, aminopurvalanol.a, abemaciclib, palbociclib, BMS.265246, ribociclib",1.33348201944512,0.421360790031928,FALSE
+"H1703","Pearson.est","CHK inhibitor",-0.62168,-1.57,0.0522,1139,0.379,"LY2606368, LY2603618, SCH.900776, SB.218078",1.28232949699774,0.421360790031928,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",-0.32176,-0.807,0.716,1188,0.783,"FR.122047, tepoxalin, curcumin, ketoprofen, acetylsalicylsalicylic.acid",0.145086977692144,0.106238237942057,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",0.51747,1.42,0.118,94,0.408,"morin, PF.4981517",0.928117992693875,0.38933983691012,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.4152,-1.02,0.444,873,0.596,"carboplatin, satraplatin, melphalan, mitomycin.c, cyclophosphamide, TH.302, dianhydrogalactitol",0.35261702988538,0.224753740259764,FALSE
+"H1703","Pearson.est","DNA inhibitor",-0.20202,-0.504,0.984,1004,0.993,"melphalan, oxaliplatin, chlorambucil, teroxirone, primaquine, pibenzimol",0.00700490156865849,0.00305075150461883,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",-0.61742,-1.55,0.0531,1186,0.33,"disulfiram, RG108, decitabine",1.27490547891853,0.481486060122112,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",0.37038,1.04,0.383,268,0.666,"famciclovir, foscarnet, menadione",0.416801226031377,0.176525770829699,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.46225,-1.19,0.271,932,0.534,"nelarabine, CB.10.277, enocitabine, artesunate, mitomycin.c, azodicarbonamide, cyclocytidine, anisomycin",0.567030709125594,0.272458742971444,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.27466,0.772,0.767,430,0.85,"clebopride, domperidone, thioproperazine, acetophenazine, sertindole, ziprasidone, remoxipride, UH.232...., isofloxythepin, lurasidone",0.115204636051019,0.0705810742857073,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",0.50152,1.42,0.123,313,0.408,"erteberel, ethinyl.estradiol, levonorgestrel, estradiol",0.910094888560602,0.38933983691012,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",-0.37867,-0.945,0.539,939,0.639,"danazol, raloxifene, fulvestrant",0.268411234813261,0.1944991418416,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.40641,-1.02,0.441,1296,0.596,"AZD4547, nintedanib",0.355561410532161,0.224753740259764,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",-0.46753,-1.18,0.279,975,0.532,"tyrphostin.AG.1296, KW.2449, TG.101348, TG.02, sunitinib, quizartinib, midostaurin, tozasertib, lestaurtinib, pacritinib",0.554395796726402,0.274088367704952,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",-0.4207,-1.05,0.413,760,0.595,"methylprednisolone, prednisolone.hemisuccinate, prednisolone, triamcinolone.acetonide, halobetasol.propionate, prednisolone.acetate, deflazacort, flumethasone.pivalate, difluprednate, triamcinolone, dexamethasone.acetate, rimexolone, desonide, clobetasol.propionate, fluorometholone, halcinonide, flumethasone, beclomethasone.dipropionate, fluocinolone.acetonide, fluticasone.propionate",0.384049948343599,0.22548303427145,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.20445,0.578,0.927,395,0.942,"kynurenic.acid, diazooxonorleucine, JNJ.16259685, felbamate, CGP.37849, latrepirdine",0.0329202658555029,0.0259490972071227,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",-0.32743,-0.822,0.678,714,0.777,"GSK.3.inhibitor.IX, tideglusib, TWS.119, indirubin, LY2090314, AZD2858",0.168770306132937,0.109578981199086,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",-0.66629,-1.66,0.033,1098,0.488,"PHA.848125, danusertib, AZD3463, lestaurtinib",1.48148606012211,0.311580177997289,FALSE
+"H1703","Pearson.est","HCV inhibitor",0.38311,1.06,0.363,161,0.671,"daclatasvir, PSI.7976",0.440093374963888,0.173277479831008,FALSE
+"H1703","Pearson.est","HDAC inhibitor",-0.66207,-1.64,0.0344,1124,0.425,"scriptaid, SB.939, PCI.24781, trichostatin.a, romidepsin, chidamide, mocetinostat, belinostat, vorinostat, M.344, entinostat, RG2833, resminostat, givinostat, dacinostat, AR.42, ACY.1215",1.46344155742847,0.371611069949688,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.22612,0.608,0.886,284,0.952,"chloropyramine, famotidine, terfenadine, ranitidine, cyproheptadine, epinastine, zolantidine, cimetidine",0.0525662781129492,0.0213630516155257,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.53486,-1.32,0.168,1386,0.448,"simvastatin",0.774690718274137,0.348721986001856,FALSE
+"H1703","Pearson.est","HSP inhibitor",-0.54803,-1.38,0.112,879,0.536,"NMS.E973, XL888, PU.H71, BIIB021, SNX.2112, alvespimycin, NVP.AUY922, VER.49009, tanespimycin, ganetespib",0.950781977329818,0.27083521030723,FALSE
+"H1703","Pearson.est","JAK inhibitor",-0.52109,-1.31,0.178,1378,0.444,"tozasertib, AZ960, AT.9283, PRT062070, lestaurtinib, pacritinib",0.749579997691106,0.35261702988538,FALSE
+"H1703","Pearson.est","KIT inhibitor",-0.38699,-0.976,0.476,1195,0.636,"masitinib, sunitinib, telatinib, imatinib, midostaurin, vatalanib",0.322393047279507,0.196542884351586,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.71857,-1.79,0.013,1225,0.268,"AMG.232, idasanutlin, RITA, CGM097",1.88605664769316,0.571865205971211,FALSE
+"H1703","Pearson.est","MEK inhibitor",-0.44864,-1.12,0.34,1009,0.579,"cobimetinib, MEK162, arctigenin, trametinib, PD.184352, Ro.4987655, AS.703026, selumetinib, AZD8330, TAK.733, refametinib, nobiletin",0.468521082957745,0.237321436272564,FALSE
+"H1703","Pearson.est","MET inhibitor",-0.53999,-1.36,0.126,902,0.506,"PHA.665752, AMG458, NVP.BVU972",0.899629454882437,0.295849483160201,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.53803,-1.34,0.163,910,0.437,"vinflunine, colchicine, secnidazole, cytochalasin.b, D.64131, cabazitaxel",0.787812395596042,0.359518563029578,FALSE
+"H1703","Pearson.est","mTOR inhibitor",-0.1493,-0.377,0.999,212,0.998,"AZD8055, PP242, PI.103, palomid.529, everolimus, deforolimus, LY3023414, temsirolimus, voxtalisib, torin.2, torin.1, WYE.125132, WAY.600, OSI.027, PKI.179, MLN0128, ku.0063794, GDC.0980, sirolimus, XL388, GSK2126458, AZD2014, PF.04691502, NVP.BEZ235, LY303511, SB.2343, PF.05212384, WYE.354",0.000434511774017692,0.000869458712628891,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.45352,-1.11,0.318,1234,0.561,"betulinic.acid, curcumin, Ro.106.9920",0.497572880015567,0.251037138743839,FALSE
+"H1703","Pearson.est","opioid receptor agonist",-0.32203,-0.804,0.724,1315,0.771,"salvinorin.a",0.140261433802853,0.112945621949043,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.28586,0.803,0.673,331,0.873,"SB.242235, TAK.715, SB.239063",0.171984935776023,0.0589857562944303,FALSE
+"H1703","Pearson.est","PARP inhibitor",-0.49584,-1.24,0.224,947,0.531,"endo.IWR.1, talazoparib, niraparib, AZD2461",0.649751981665837,0.274905478918531,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.42906,-1.05,0.401,1158,0.595,"trapidil, masitinib, sunitinib, telatinib, crenolanib, imatinib, axitinib, vatalanib, nintedanib",0.396855627379818,0.22548303427145,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",0.23721,0.674,0.848,268,0.918,"alexidine, sodium.stibogluconate, mycophenolate.mofetil, menadione",0.0716041477432862,0.0371573187987575,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",0.35317,0.975,0.438,102,0.749,"avanafil, cilostamide",0.3585258894959,0.125518182300534,FALSE
+"H1703","Pearson.est","PI3K inhibitor",-0.27303,-0.683,0.849,865,0.892,"PF.04691502, TG.100713, GDC.0941, NVP.BEZ235, CH5132799, LY303511, taselisib, alpelisib, ZSTK.474, SB.2343, pilaralisib, PF.05212384, CUDC.907, YM.201636, PIK.75",0.0710923097560473,0.0496351456238769,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.6063,-1.49,0.0725,937,0.378,"NMS.1286937, volasertib, GW.843682X, BI.2536, rigosertib, GSK461364",1.13966199342901,0.422508200162775,FALSE
+"H1703","Pearson.est","potassium channel blocker",0.38707,1.1,0.303,394,0.692,"meglitinide, ibutilide, dofetilide, ML133, oleoylethanolamide",0.518557371497695,0.159893905543242,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",0.40736,1.12,0.303,861,0.706,"pterostilbene, ciprofibrate, oleoylethanolamide, GW.501516, fenofibrate, clofibrate, S26948",0.518557371497695,0.151195298948196,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",0.47706,1.31,0.149,207,0.466,"dienogest, norethindrone.acetate, levonorgestrel",0.826813731587726,0.33161408331,FALSE
+"H1703","Pearson.est","proteasome inhibitor",-0.53882,-1.36,0.144,809,0.506,"bortezomib, ONX.0914, oprozomib, ixazomib.citrate, carfilzomib, ixazomib",0.84163750790475,0.295849483160201,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.4479,-1.11,0.341,1175,0.561,"thiostrepton, mercaptopurine, cycloheximide, bruceantin, harringtonine, emetine, homoharringtonine",0.467245621007502,0.251037138743839,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.45099,-1.12,0.349,711,0.579,"NVP.TAE226, mubritinib, CP.724714, AV.412, tyrphostin.A9, PP.121, rheochrysidin",0.45717457304082,0.237321436272564,FALSE
+"H1703","Pearson.est","RAF inhibitor",-0.33228,-0.822,0.685,981,0.777,"regorafenib, CEP.32496, LGX818, TAK.632, AZ.628",0.164309428507574,0.109578981199086,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",-0.54122,-1.35,0.129,832,0.467,"vandetanib, regorafenib, sunitinib, cabozantinib",0.889410289700751,0.330683119433888,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",0.65065,1.86,0.00694,51,0.289,"adarotene, tamibarotene, adapalene",2.15864052954515,0.539102157243452,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.62561,-1.56,0.0523,1181,0.351,"pentostatin, gemcitabine, clofarabine, fludarabine",1.28149831113273,0.454692883534176,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",0.38751,1.07,0.341,170,0.697,"NAN.190, SR.57227A",0.467245621007502,0.156767221901991,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",0.32067,0.896,0.528,372,0.867,"SB.200646, sertindole, ziprasidone, pirenperone, tropisetron, lerisetron",0.277366077466188,0.0619809025237897,FALSE
+"H1703","Pearson.est","sodium channel blocker",0.32367,0.895,0.55,168,0.824,"ajmaline, brivaracetam, benzethonium, A.803467",0.259637310505756,0.0840727883028842,FALSE
+"H1703","Pearson.est","src inhibitor",-0.39011,-0.978,0.479,936,0.648,"ZM.306416, saracatinib, masitinib, KX2.391, bosutinib",0.319664486585437,0.188424994129407,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.61284,-1.53,0.0578,1437,0.333,"ketoconazole",1.23807216157947,0.47755576649368,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",-0.41387,-1.03,0.412,967,0.611,"SB.525334, SB.431542, repsox",0.385102783966865,0.213958789757446,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",-0.39079,-0.961,0.503,670,0.63,"raltitrexed, capecitabine, doxifluridine, carmofur",0.298432014944073,0.200659450546418,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.53938,-1.34,0.158,1152,0.437,"mitoxantrone, fleroxacin, etoposide, amsacrine, licochalcone.a, daunorubicin, TAS.103, SN.38, voreloxin, camptothecin, amonafide, teniposide",0.801342913045577,0.359518563029578,FALSE
+"H1703","Pearson.est","tubulin polymerization inhibitor",-0.51685,-1.3,0.171,988,0.442,"flubendazole, ABT.751, vindesine, verubulin, dolastatin.10, CYT.997, oxibendazole, parbendazole, docetaxel, KX2.391, fosbretabulin, combretastatin.A.4, epothilone.b, epothilone.d, plinabulin",0.767003889607846,0.354577730650908,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",-0.38823,-0.969,0.494,981,0.632,"regorafenib, AV.412, tyrphostin.A9, PP.121, rheochrysidin, sunitinib, cabozantinib, AMG.208, UNC2250, aminopurvalanol.a, tyrphostin.AG.99",0.306273051076353,0.199282921717615,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",-0.24131,-0.605,0.902,1198,0.951,"sunitinib, cabozantinib, telatinib, axitinib, vatalanib, nintedanib",0.0447934624580583,0.0218194830625861,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",-0.76748,-1.94,0,1187,0.119,"maxacalcitol, paricalcitol, calcitriol, alfacalcidol, doxercalciferol, tacalcitol",Inf,0.924453038607469,TRUE
+"H1299","Pearson.est","EGFR inhibitor",-0.26174,-0.626,0.928,731,1,"OSI.420, dovitinib, AST.1306, afatinib, XL.647, ARRY.334543, vandetanib, TAK.285, rociletinib, pelitinib, PD.153035, BIBU.1361, CUDC.101, dacomitinib, BMS.599626, CP.724714, FERb.033, neratinib, salvianolic.acid.B, tucatinib",0.0324520237811379,0,FALSE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.67294,-1.63,0.0152,1194,0.365,"imatinib, nilotinib, bosutinib, KW.2449, tozasertib, ponatinib, flumatinib",1.81815641205523,0.437707135543525,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.48333,-1.17,0.259,768,0.499,"nefiracetam, xanomeline, oxiracetam, tremorine, pilocarpine",0.586700235918748,0.30189945437661,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",-0.52439,-1.26,0.183,853,0.478,"diphemanil, iododexetimide, dicycloverine, methscopolamine",0.737548910269571,0.320572103387881,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",-0.49567,-1.18,0.249,841,0.493,"theophylline, istradefylline, PSB.1115, sulmazole",0.603800652904264,0.30715308072277,FALSE
+"H1299","Pearson.est","adrenergic receptor agonist",-0.44538,-1.07,0.373,1133,0.641,"oxymetazoline, epinephrine, isoetharine, clenbuterol, midodrine",0.428291168191312,0.193141970481183,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",-0.19694,-0.477,0.986,507,1,"RS.17053, dronedarone, prazosin, atipamezole, dihydroergocristine, atenolol......, naftidrofuryl, levobunolol, vincamine, imiloxan, propranolol, oxprenolol, pindolol, carvedilol, atenolol...., idazoxan",0.0061230850587888,0,FALSE
+"H1299","Pearson.est","AKT inhibitor",-0.57258,-1.38,0.0951,1263,0.341,"palomid.529, uprosertib, CCT128930, AT7867",1.02181948306259,0.467245621007502,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25713,-0.624,0.917,839,1,"alectinib, AP26113, CEP.37440, AZD3463, DMH1",0.0376306643299789,0,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",-0.52466,-1.25,0.186,1225,0.451,"bicalutamide, flutamide",0.730487055782084,0.345823458122039,FALSE
+"H1299","Pearson.est","antioxidant",-0.52653,-1.25,0.194,849,0.451,"chlorogenic.acid, mesna, trolox, taurine, benfotiamine",0.712198270069774,0.345823458122039,FALSE
+"H1299","Pearson.est","AP inhibitor",0.45684,1.41,0.0992,146,1,"birinapant, tanshinone.i, GDC.0152",1.00348832784582,0,FALSE
+"H1299","Pearson.est","ATPase inhibitor",0.31584,0.963,0.503,47,0.691,"k.strophanthidin, thonzonium",0.298432014944073,0.160521952625802,FALSE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.56818,-1.38,0.0971,1131,0.341,"CCT129202, CCT137690, barasertib.HQPA, barasertib, MK.8745, hesperadin, KW.2449, alisertib, tozasertib, ZM.447439, danusertib, SNS.314, ENMD.2076, AT.9283",1.012780770092,0.467245621007502,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.67192,-1.62,0.0234,1000,0.262,"tedizolid, radezolid, valnemulin, josamycin, dirithromycin, tilmicosin, azalomycin.b",1.63078414258986,0.581698708680255,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.38017,1.2,0.194,203,0.566,"lomefloxacin, sparfloxacin, nadifloxacin",0.712198270069774,0.247183568811729,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.3934,-0.947,0.546,843,0.813,"gossypol, obatoclax, TW.37, venetoclax",0.262807357295263,0.0899094544059319,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.68093,-1.63,0.0245,1194,0.365,"imatinib, nilotinib, bosutinib, tozasertib, ponatinib, flumatinib",1.61083391563547,0.437707135543525,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.23484,0.705,0.821,1111,0.928,"gamma.aminobutyric.acid, ivermectin, bentazepam, eprinomectin, indiplon, zaleplon, CL.218872, ZK.93423, temazepam, nefiracetam, CGS.20625, lorazepam, piperazine",0.0856568428805592,0.0324520237811379,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",-0.82247,-1.96,0.0023,1186,0.0435,"OTX015, I.BET151, I.BET.762, PFI.1, bromosporine, JQ1....",2.63827216398241,1.36151074304536,TRUE
+"H1299","Pearson.est","calcium channel blocker",-0.36033,-0.877,0.639,818,0.855,"tetrandrine, carboxyamidotriazole, cinnarazine, mibefradil, pranidipine",0.1944991418416,0.0680338852718274,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.32807,-0.791,0.772,926,0.938,"PF.04136309, SB.225002, RS.504393, MK.0812",0.112382699664264,0.0277971616209356,FALSE
+"H1299","Pearson.est","CDK inhibitor",-0.61917,-1.47,0.0659,1125,0.355,"BMS.265246, indisulam, R547, P276.00, AZD5438, PHA.793887, AT.7519, JNJ.7706621, PHA.848125, BMS.387032, aminopurvalanol.a, TG.02, palbociclib, ribociclib, dinaciclib, abemaciclib",1.18111458540599,0.449771646944906,FALSE
+"H1299","Pearson.est","CHK inhibitor",-0.36118,-0.87,0.654,1399,0.837,"SB.218078",0.184422251675733,0.07727454200674,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",-0.39141,-0.943,0.555,1190,0.805,"acetylsalicylsalicylic.acid, FR.122047, ketoprofen, aspirin, piroxicam, phenazone",0.255707016877324,0.0942041196321315,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",-0.4425,-1.07,0.37,671,0.641,"clotrimazole, morin, PF.4981517, itraconazole, cobicistat, eplerenone",0.431798275933005,0.193141970481183,FALSE
+"H1299","Pearson.est","DNA alkylating agent",-0.36108,-0.875,0.645,1285,0.843,"temozolomide, TH.302, estramustine",0.190440285364732,0.0741724253752577,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.14695,-0.357,0.998,1407,1,"primaquine",0.000869458712628891,0,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",-0.63776,-1.53,0.0318,1249,0.414,"RG108, decitabine, SGI.1027",1.49757288001557,0.382999658879101,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",-0.61714,-1.5,0.0457,1389,0.354,"trifluridine, idoxuridine",1.34008379993015,0.450996737974212,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",-0.19491,-0.475,0.991,730,1,"artesunate, anisomycin, cyclocytidine, mitomycin.c, enocitabine, CB.10.277, azodicarbonamide, capecitabine",0.00392634551472468,0,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",-0.28311,-0.678,0.869,1068,1,"sertindole, mesoridazine, ziprasidone, UH.232...., raclopride, paliperidone",0.0609802235513335,0,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",-0.42809,-1.04,0.421,963,0.678,"estradiol, estradiol.cypionate, estrone, PPT",0.375717904164332,0.168770306132937,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.68337,-1.66,0.0207,1411,0.586,"clomifene, tamoxifen",1.68402965454308,0.232102383981909,FALSE
+"H1299","Pearson.est","FGFR inhibitor",-0.41503,-1.01,0.463,1287,0.726,"nintedanib, regorafenib, lucitanib",0.334419008982047,0.139063379299906,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.56028,-1.35,0.0959,1023,0.348,"quizartinib, gilteritinib, sorafenib, lestaurtinib, KW.2449, pacritinib, tandutinib, tozasertib, TG.02, ponatinib, ENMD.2076",1.01818139282934,0.458420756053419,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",-0.27774,-0.664,0.901,989,1,"halobetasol.propionate, fluocinolone.acetonide, flumethasone.pivalate, fluticasone.propionate, methylprednisolone, flumethasone, difluprednate, halcinonide, prednisolone, betamethasone",0.045275209020937,0,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",-0.22613,-0.541,0.95,1098,1,"tiletamine, IEM1754, JNJ.16259685",0.0222763947111523,0,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.30021,0.928,0.568,1016,0.661,"CHIR.98014, AZD2858, TWS.119, tideglusib, GSK.3.inhibitor.IX, indirubin, LY2090314, CHIR.99021, kenpaullone",0.245651664288981,0.17979854051436,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",-0.62941,-1.52,0.0498,1154,0.389,"lestaurtinib, AZD3463, danusertib, PHA.848125, GSK1838705A",1.30277065724028,0.410050398674292,FALSE
+"H1299","Pearson.est","HCV inhibitor",-0.5684,-1.37,0.0906,1362,0.327,"mericitabine, narlaprevir",1.04287180232319,0.485452247339714,FALSE
+"H1299","Pearson.est","HDAC inhibitor",-0.41596,-0.991,0.487,988,0.752,"ACY.1215, AR.42, R306465, RGFP966, givinostat, belinostat, resminostat, vorinostat, trichostatin.a, dacinostat, M.344, RG2833",0.312471038785366,0.123782159408358,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",-0.43323,-1.05,0.413,942,0.672,"pheniramine, levocetirizine, lafutidine, BF2.649, cimetidine, nizatidine, ICI.162846, tiotidine, ebastine",0.384049948343599,0.172630726946175,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",0.41262,1.34,0.0916,853,0.459,"mevastatin, fluvastatin, simvastatin, lovastatin, pitavastatin, atorvastatin",1.03810452633215,0.338187314462739,FALSE
+"H1299","Pearson.est","HSP inhibitor",-0.57625,-1.39,0.0955,888,0.357,"KW.2478, guanidine, VER.49009, BIIB021, NMS.E973, PU.H71, tanespimycin, ganetespib, alvespimycin, NVP.AUY922, SNX.5422, XL888",1.01999662841625,0.447331783887807,FALSE
+"H1299","Pearson.est","JAK inhibitor",-0.59818,-1.44,0.066,1102,0.394,"AZD1480, AZ960, baricitinib, lestaurtinib, TG.101209, filgotinib, pacritinib, tozasertib, PRT062070, TG.02, AT.9283",1.18045606445813,0.404503778174426,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.51484,-1.25,0.187,1099,0.451,"OSI.930, sorafenib, imatinib, tandutinib, vatalanib, regorafenib, telatinib, masitinib",0.728158393463501,0.345823458122039,FALSE
+"H1299","Pearson.est","MDM inhibitor",-0.62169,-1.51,0.0468,1171,0.37,"nutlin.3, CGM097",1.32975414692588,0.431798275933005,FALSE
+"H1299","Pearson.est","MEK inhibitor",-0.14549,-0.348,1,716,0.999,"PD.0325901, AS.703026, cobimetinib, arctigenin, selumetinib, trametinib, nobiletin",0,0.000434511774017692,FALSE
+"H1299","Pearson.est","MET inhibitor",-0.34312,-0.829,0.702,1281,0.893,"AMG458",0.153662887870195,0.0491485411114536,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.50611,-1.22,0.214,1253,0.466,"cytochalasin.b, secnidazole, D.64131",0.669586226650809,0.33161408331,FALSE
+"H1299","Pearson.est","mTOR inhibitor",0.33839,1.03,0.43,104,0.661,"SB.2343, sirolimus, WAY.600, PP242, torin.1, deforolimus, PF.05212384",0.366531544420413,0.17979854051436,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.28086,-0.681,0.88,871,1,"Ro.106.9920, EVP4593, bortezomib, IKK.2.inhibitor.V, betulinic.acid",0.0555173278498314,0,FALSE
+"H1299","Pearson.est","opioid receptor agonist",-0.67293,-1.62,0.0219,1380,0.262,"salvinorin.a, trimebutine",1.65955588515988,0.581698708680255,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",-0.54933,-1.32,0.126,865,0.389,"SB.242235, talmapimod, SB.239063, skepinone.l, VX.702",0.899629454882437,0.410050398674292,FALSE
+"H1299","Pearson.est","PARP inhibitor",-0.45596,-1.09,0.354,828,0.625,"AZD2461, PJ.34, niraparib, AG.14361, E7449, talazoparib",0.450996737974212,0.204119982655925,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.57578,-1.39,0.0906,1122,0.357,"sorafenib, trapidil, imatinib, tandutinib, nintedanib, vatalanib, regorafenib, axitinib, ponatinib, telatinib, CP.673451, crenolanib, masitinib",1.04287180232319,0.447331783887807,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.37334,-0.903,0.624,1435,0.837,"CID.5458317",0.204815410317576,0.07727454200674,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",-0.49873,-1.2,0.234,1038,0.479,"EMD.53998, trequinsin, cilostamide, GSK256066",0.630784142589857,0.319664486585437,FALSE
+"H1299","Pearson.est","PI3K inhibitor",-0.15449,-0.369,1,1303,1,"PIK.75, LY303511",0,0,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.60423,-1.49,0.0559,905,0.343,"GW.843682X, NMS.1286937, GSK461364, BI.2536, rigosertib, volasertib",1.25258819211358,0.464705879957229,FALSE
+"H1299","Pearson.est","potassium channel blocker",-0.47388,-1.13,0.299,1347,0.553,"mepivacaine",0.52432881167557,0.257274868695302,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",0.44451,1.35,0.109,154,0.665,"pterostilbene, clofibrate, GW.501516",0.962573502059376,0.177178354696895,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",0.18207,0.54,0.961,1186,0.97,"levonorgestrel, norethindrone.acetate, norethindrone, tanaproget, dienogest, norgestrel, melengestrol.acetate, danazol, nomegestrol.acetate",0.0172766123314547,0.0132282657337552,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.4746,-1.16,0.289,907,0.506,"MG.132, carfilzomib, ixazomib, bortezomib, ixazomib.citrate",0.539102157243452,0.295849483160201,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.24067,-0.576,0.951,1120,1,"thiostrepton, harringtonine, bruceantin, anguidine, puromycin",0.0218194830625861,0,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.52047,-1.24,0.184,1049,0.442,"BMS.599626, rheochrysidin, CP.724714, AV.412",0.735182176990464,0.354577730650908,FALSE
+"H1299","Pearson.est","RAF inhibitor",-0.58608,-1.41,0.0848,1021,0.434,"PLX.4720, dabrafenib, sorafenib, RAF265, GDC.0879, AZ.628, regorafenib, TAK.632",1.07160414774329,0.362510270487489,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.51143,-1.21,0.219,749,0.474,"cabozantinib, sunitinib, vandetanib, sorafenib, regorafenib",0.659555885159882,0.324221658325915,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",0.35069,1.06,0.348,166,0.723,"adapalene, LE.135, CD.437",0.458420756053419,0.140861702705469,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.59172,-1.4,0.0931,980,0.402,"cladribine, pentostatin, hydroxyurea, fludarabine, clofarabine, fludarabine.phosphate",1.03105031901866,0.39577394691553,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",-0.56197,-1.37,0.108,1134,0.327,"zolmitriptan, aripiprazole, ipsapirone",0.96657624451305,0.485452247339714,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",-0.51954,-1.24,0.183,981,0.442,"SB.228357, sertindole, ziprasidone, aripiprazole, paliperidone, RS.16566, SB.216641",0.737548910269571,0.354577730650908,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.32831,-0.781,0.775,1130,0.938,"triamterene, oxcarbazepine, mepivacaine, quinidine",0.11069829749369,0.0277971616209356,FALSE
+"H1299","Pearson.est","src inhibitor",-0.52495,-1.27,0.17,1226,0.475,"KX2.391, bosutinib, PP.1, masitinib",0.769551078621726,0.323306390375133,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.36286,-0.878,0.627,883,0.869,"ketoconazole, chlormidazole, posaconazole",0.202732459169284,0.0609802235513335,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",-0.57317,-1.39,0.0936,1295,0.357,"LY2109761, D.4476",1.02872415126189,0.447331783887807,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",-0.57902,-1.4,0.103,961,0.402,"raltitrexed, carmofur, capecitabine, trifluridine",0.987162775294828,0.39577394691553,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.20093,-0.489,0.979,588,1,"idarubicin, amsacrine, irinotecan, camptothecin, TAS.103, genz.644282, SN.38, dexrazoxane, etoposide, licochalcone.a, valrubicin, teniposide, exatecan.mesylate, fleroxacin, etoposide.phosphate, amonafide, daunorubicin",0.00921730819686218,0,FALSE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.49628,-1.18,0.24,872,0.493,"vinblastine, nocodazole, epothilone.b, verubulin, plinabulin, flubendazole, vincristine, taltobulin, vindesine, vinorelbine, KX2.391, ABT.751, parbendazole, combretastatin.A.4, docetaxel, albendazole, paclitaxel, fosbretabulin",0.619788758288394,0.30715308072277,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",-0.38829,-0.941,0.533,728,0.793,"bafetinib, cabozantinib, sunitinib, vandetanib, AMG.208, hypericin, BMS.599626, rheochrysidin, UNC2250, CP.724714, sorafenib, AV.412, regorafenib, aminopurvalanol.a, tivantinib",0.273272790973428,0.100726812682396,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.3965,-0.965,0.527,722,0.79,"cediranib, dovitinib, XL.647, cabozantinib, SAR131675, sunitinib, MK.2461, pazopanib, vandetanib, KI.8751, PD.173074, TG.100572, OSI.930, sorafenib, RAF265, tivozanib, nintedanib, foretinib, vatalanib, regorafenib, axitinib, telatinib, golvatinib, lucitanib, ENMD.2076",0.278189384787453,0.102372908709559,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",-0.37323,-0.905,0.6,1074,0.849,"doxercalciferol, alfacalcidol, tacalcitol",0.221848749616356,0.0710923097560473,FALSE
diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/DMEA/DMEA_venn_diagram.pdf
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diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_correlation_matrix.pdf b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_correlation_matrix.pdf
new file mode 100644
index 0000000..f7f7755
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diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_dot_plot.pdf b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_dot_plot.pdf
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diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_interactive_network.graph.html b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_interactive_network.graph.html
new file mode 100644
index 0000000..892e7b3
--- /dev/null
+++ b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-8dcd6e54c039cbb3d841" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_mean_results.csv b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_mean_results.csv
new file mode 100644
index 0000000..8dcb4e1
--- /dev/null
+++ b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_mean_results.csv
@@ -0,0 +1,3 @@
+"Feature_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"alpha amino acids",0.0415,1.15505777937046,0.166152839512075,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"H520",0.166152839512075
+"acyl carnitines",-0.2254,1.32928787425131,0.00108227266904627,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"H2126, HCC2279, H460",0.00216454533809254
diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_results.csv b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_results.csv
new file mode 100644
index 0000000..520d7c9
--- /dev/null
+++ b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_results.csv
@@ -0,0 +1,41 @@
+"type","Rank_metric","Feature_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H358","Input","alpha amino acids",-0.28972,-1.01,0.427,62,0.435,"sarcosine, homocysteine, glycine, citrulline, dimethylglycine, creatinine, betaine, acetylglycine, ornithine, phosphocreatine, creatine",0.369572124974976,0.361510743045363,FALSE
+"H358","Input","acyl carnitines",-0.38991,-1.41,0.119,85,0.227,"propionylcarnitine, heptanoylcarnitine, stearoylcarnitine, malonylcarnitine, hexanoylcarnitine, palmitoylcarnitine, myristoylcarnitine",0.924453038607469,0.643974142806877,FALSE
+"H1650","Input","alpha amino acids",-0.41638,-1.49,0.0853,173,0.1,"glycine, creatinine, betaine, ornithine, dimethylglycine, creatine, citrulline",1.06905096883248,1,FALSE
+"H1650","Input","acyl carnitines",0.36239,1.24,0.191,146,0.195,"hexanoylcarnitine, myristoylcarnitine, heptanoylcarnitine, malonylcarnitine, palmitoylcarnitine, stearoylcarnitine, propionylcarnitine",0.718966632752272,0.709965388637482,FALSE
+"HCC95","Input","alpha amino acids",-0.26711,-0.967,0.478,79,0.485,"homocysteine, creatine, glycine, citrulline, creatinine, dimethylglycine, betaine, sarcosine, acetylglycine, ornithine",0.320572103387881,0.314258261397736,FALSE
+"HCC95","Input","acyl carnitines",-0.38991,-1.37,0.123,85,0.293,"stearoylcarnitine, propionylcarnitine, palmitoylcarnitine, myristoylcarnitine, malonylcarnitine, heptanoylcarnitine, hexanoylcarnitine",0.910094888560602,0.533132379645891,FALSE
+"H3255","Input","alpha amino acids",0.33475,1.2,0.229,115,0.236,"homocysteine, creatine, acetylglycine, sarcosine, glycine, citrulline, dimethylglycine, creatinine, betaine",0.640164517660112,0.627087997029893,FALSE
+"H3255","Input","acyl carnitines",-0.35088,-1.24,0.21,179,0.216,"propionylcarnitine, myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.677780705266081,0.665546248849069,FALSE
+"H1648","Input","alpha amino acids",0.21893,0.775,0.727,40,0.736,"phosphocreatine, creatine, creatinine, glycine",0.138465589140962,0.133122185662501,FALSE
+"H1648","Input","acyl carnitines",0.25529,0.888,0.589,13,1,"palmitoylcarnitine, myristoylcarnitine",0.229884705212898,0,FALSE
+"H1975","Input","alpha amino acids",0.30803,1.07,0.36,39,0.361,"homocysteine, creatinine, dimethylglycine, phosphocreatine, ornithine",0.443697499232713,0.442492798094342,FALSE
+"H1975","Input","acyl carnitines",-0.41428,-1.45,0.104,125,0.1,"heptanoylcarnitine, hexanoylcarnitine, malonylcarnitine, stearoylcarnitine, myristoylcarnitine, palmitoylcarnitine",0.98296666070122,1,FALSE
+"HCC78","Input","alpha amino acids",-0.28078,-1,0.446,103,0.904,"phosphocreatine, citrulline, dimethylglycine, creatinine, homocysteine, betaine, creatine, ornithine, acetylglycine",0.350665141287858,0.0438315695246367,FALSE
+"HCC78","Input","acyl carnitines",-0.27409,-0.982,0.474,126,0.469,"hexanoylcarnitine, myristoylcarnitine, palmitoylcarnitine, stearoylcarnitine, heptanoylcarnitine",0.324221658325915,0.328827157284917,FALSE
+"H2126","Input","alpha amino acids",-0.28519,-1.01,0.41,104,0.42,"betaine, phosphocreatine, homocysteine, sarcosine, creatine, creatinine, dimethylglycine, citrulline, ornithine",0.387216143280265,0.3767507096021,FALSE
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+"HCC827","Input","alpha amino acids",0.26472,0.913,0.539,149,0.546,"ornithine, phosphocreatine, sarcosine, dimethylglycine, creatinine, glycine, creatine, homocysteine, betaine, citrulline",0.268411234813261,0.262807357295263,FALSE
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+"CALU3","Input","alpha amino acids",-0.44662,-1.64,0.0501,163,0.0402,"sarcosine, creatine, dimethylglycine, betaine, citrulline, creatinine, glycine, phosphocreatine",1.30016227413275,1.39577394691553,FALSE
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+"H2009","Input","alpha amino acids",-0.30219,-1.08,0.359,150,0.724,"betaine, ornithine, creatinine, citrulline, sarcosine, dimethylglycine, homocysteine",0.444905551421681,0.140261433802853,FALSE
+"H2009","Input","acyl carnitines",-0.23817,-0.874,0.576,87,0.595,"stearoylcarnitine, palmitoylcarnitine, heptanoylcarnitine, myristoylcarnitine, propionylcarnitine, hexanoylcarnitine",0.239577516576788,0.22548303427145,FALSE
+"HCC4006","Input","alpha amino acids",0.24766,0.88,0.589,172,0.607,"sarcosine, glycine, betaine, creatine, acetylglycine, ornithine, phosphocreatine, creatinine, homocysteine, citrulline, dimethylglycine",0.229884705212898,0.216811308924742,FALSE
+"HCC4006","Input","acyl carnitines",-0.30744,-1.09,0.344,100,0.351,"stearoylcarnitine, hexanoylcarnitine, propionylcarnitine, malonylcarnitine, palmitoylcarnitine, heptanoylcarnitine",0.46344155742847,0.454692883534176,FALSE
+"HCC2279","Input","alpha amino acids",-0.23263,-0.818,0.733,136,0.705,"betaine, creatinine, acetylglycine, glycine, creatine, sarcosine, phosphocreatine",0.134896025358872,0.151810883008601,FALSE
+"HCC2279","Input","acyl carnitines",0.55124,1.93,0.00977,75,0.0076,"stearoylcarnitine, palmitoylcarnitine, myristoylcarnitine, propionylcarnitine, malonylcarnitine, hexanoylcarnitine",2.01010543628123,2.11918640771921,TRUE
+"H520","Input","alpha amino acids",0.55543,1.95,0.00704,69,0.0214,"homocysteine, phosphocreatine, sarcosine, betaine, creatinine, ornithine, dimethylglycine, creatine, glycine",2.15242734085789,1.66958622665081,TRUE
+"H520","Input","acyl carnitines",0.37677,1.34,0.167,115,0.157,"hexanoylcarnitine, malonylcarnitine, myristoylcarnitine, propionylcarnitine, heptanoylcarnitine, palmitoylcarnitine",0.777283528852417,0.804100347590766,FALSE
+"HCC15","Input","alpha amino acids",-0.19164,-0.694,0.847,64,0.851,"ornithine, creatinine, dimethylglycine, acetylglycine, sarcosine, betaine, citrulline, glycine, creatine, phosphocreatine",0.0721165896692931,0.0700704399154121,FALSE
+"HCC15","Input","acyl carnitines",0.37551,1.31,0.168,112,0.161,"myristoylcarnitine, palmitoylcarnitine, hexanoylcarnitine, stearoylcarnitine, malonylcarnitine, propionylcarnitine",0.774690718274137,0.79317412396815,FALSE
+"H460","Input","alpha amino acids",0.33725,1.19,0.246,134,0.257,"homocysteine, phosphocreatine, sarcosine, creatine, dimethylglycine, creatinine, citrulline, ornithine, glycine, betaine",0.609064892896621,0.590066876668705,FALSE
+"H460","Input","acyl carnitines",-0.46083,-1.69,0.0309,208,0.0365,"myristoylcarnitine, heptanoylcarnitine, palmitoylcarnitine, stearoylcarnitine",1.51004152057517,1.43770713554353,TRUE
+"A549","Input","alpha amino acids",0.14945,0.523,0.97,74,0.975,"ornithine, glycine, citrulline, sarcosine, homocysteine",0.0132282657337552,0.0109953843014632,FALSE
+"A549","Input","acyl carnitines",0.42635,1.51,0.0727,39,0.14,"propionylcarnitine, malonylcarnitine, hexanoylcarnitine, stearoylcarnitine",1.13846558914096,0.853871964321762,FALSE
+"HCC44","Input","alpha amino acids",0.44653,1.59,0.0656,111,0.0648,"homocysteine, phosphocreatine, creatinine, sarcosine, dimethylglycine, ornithine, creatine, glycine, betaine, citrulline",1.18309616062434,1.18842499412941,FALSE
+"HCC44","Input","acyl carnitines",-0.26991,-0.947,0.511,192,0.501,"myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine",0.291579099865287,0.300162274132754,FALSE
+"H1703","Input","alpha amino acids",-0.16231,-0.572,0.955,182,0.948,"dimethylglycine, ornithine, betaine, sarcosine",0.0199966284162537,0.0231916626619338,FALSE
+"H1703","Input","acyl carnitines",0.32084,1.11,0.335,124,0.321,"propionylcarnitine, hexanoylcarnitine, palmitoylcarnitine, myristoylcarnitine, malonylcarnitine, stearoylcarnitine",0.474955192963155,0.493494967595128,FALSE
+"H1299","Input","alpha amino acids",0.29166,1.02,0.401,143,0.417,"homocysteine, sarcosine, citrulline, phosphocreatine, glycine, ornithine, creatinine, dimethylglycine, acetylglycine, betaine",0.396855627379818,0.379863945026242,FALSE
+"H1299","Input","acyl carnitines",-0.44634,-1.58,0.053,200,0.0553,"myristoylcarnitine, stearoylcarnitine, palmitoylcarnitine, heptanoylcarnitine",1.27572413039921,1.2572748686953,FALSE
diff --git a/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_venn_diagram.pdf b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_venn_diagram.pdf
new file mode 100644
index 0000000..870d653
Binary files /dev/null and b/Examples/cell_corr/Fig9_Coldren_met_NSCLC/GSEA/GSEA_venn_diagram.pdf differ
diff --git a/Examples/panSEA_examples.R b/Examples/panSEA_examples.R
new file mode 100644
index 0000000..1789b38
--- /dev/null
+++ b/Examples/panSEA_examples.R
@@ -0,0 +1,256 @@
+# panSEA examples
+# Author: Belinda B. Garana (BG)
+# Date created: 2023-12-21
+# Last edit: BG 2023-12-21
+
+# To recreate: press run through the whole script
+# Overview
+# 1 - import CCLE data
+# 2 - import Coldren et al. data
+# 3 - import GSE31625 data
+# 4 - import GSE12790 data
+# 5 - run panSEA
+
+rm(list=ls(all=TRUE))
+library(plyr);library(dplyr);library(GSA);library(panSEA);library(GEOquery)
+
+##### Step 1: Import CCLE data (PRISM drug AUC, drug moa gmt, RNAseq, proteomics, metabolomics) #####
+#### cell line info (CCLE 19Q4)
+cell.line.info <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/CCLE_sample_info.csv")
+cell.line.info$X <- NULL
+
+#### drug sensitivity (PRISM AUC) for 481 cancer cell lines
+AUC.df <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/PRISM_drug_mean_AUC_6-23-21.csv")
+AUC.df$X <- NULL
+
+#### drug sets (PRISM moa)
+gmt <- GSA.read.gmt(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/MOA_gmt_file_n6_no_special_chars.gmt")
+
+#### RNAseq (CCLE 19Q4) for 327 adherent cancer cell lines
+download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin", 
+              destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin"))
+load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin")
+download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin", 
+              destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin"))
+load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin")
+RNA.df <- rbind(RNA.first200, RNA.rest)
+
+#### transcriptomics (IMPROVE)
+options(timeout = 360)
+download.file("https://figshare.com/ndownloader/files/42131304", "transcriptomics.csv.gz")
+transcr.df <- read.csv(gzfile("transcriptomics.csv.gz"),fileEncoding="UTF-16LE")
+
+# merge with genes, samples to stop using improve IDs
+transcr.df <- merge(transcr.df, genes)
+transcr.df <- merge(transcr.df, samples)
+
+#### proteomics (IMPROVE)
+download.file("https://figshare.com/ndownloader/files/41466702", "proteomics.csv.gz")
+prot.df <- read.csv(gzfile("proteomics.csv.gz"),fileEncoding="UTF-16LE")
+
+allgenes = readr::read_csv("https://figshare.com/ndownloader/files/40576109")
+genes = allgenes|>
+  dplyr::select(gene_symbol,entrez_id)|>
+  dplyr::distinct()
+
+allsamples = readr::read_csv('https://figshare.com/ndownloader/files/40576103')
+samples = allsamples|>
+  dplyr::select(other_id,improve_sample_id)|>
+  unique()
+
+# merge prot.df with genes, samples to stop using improve IDs
+prot.df <- merge(prot.df, genes)
+
+#### metabolomics (CCLE)
+met.df <- read.csv(paste0("~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/",
+                          "Inputs/CCLE_metabolomics_20190502.csv"))
+
+Sys.setenv("VROOM_CONNECTION_SIZE"=300000) # increase connection buffer size
+##### Step 2: Coldren et al (EGFR inhibitor ) #####
+### Identify sensitive (SENS) or resistant (RES) cells
+### based on Coldren et al, 2006 paper
+### not in CCLE RNAseq: CALU3
+SENS.cells <- c("NCIH358","NCIH322C","CALU3","NCIH1334","NCIH1648",
+                "HCC827","HCC78","NCIH2126","HCC193","HCC95",
+                "NCIH3255","HCC4006","NCIH2009","NCIH1650","NCIH820","NCIH1975")
+RES.cells <- c("NCIH125","NCIH1703","A549","NCIH157","NCIH460","NCIH520",
+               "HCC44","HCC15","NCIH157","NCIH1299","HCC2279")
+SENS.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% SENS.cells,] # 5 cell lines: NCIH1650, HCC95, NCIH1975, NCIH1648, NCIH2126
+SENS.CCLE_ID <- SENS.cell.info$CCLE_ID
+RES.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% RES.cells,] # 7 cell lines: NCIH520, NCIH460, NCIH1299, HCC44, A549, NCIH1703, HCC15
+RES.CCLE_ID <- RES.cell.info$CCLE_ID
+Coldren.samples <- list(2:6, 7:13)
+
+### Get data for SENS and RES cells
+## transcriptomics
+SENS.data <- merge(SENS.cell.info, transcr.df, by="CCLE_ID")
+SENS.data$stripped_cell_line_name <- NULL
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+RES.data <- merge(RES.cell.info, transcr.df, by="CCLE_ID")
+RES.data$stripped_cell_line_name <- NULL
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.full.transcr.data <- cbind(data.SENS,data.RES)
+
+## proteomics
+SENS.data <- merge(SENS.cell.info, prot.df, by="CCLE_ID")
+SENS.data$stripped_cell_line_name <- NULL
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+RES.data <- merge(RES.cell.info, prot.df, by="CCLE_ID")
+RES.data$stripped_cell_line_name <- NULL
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.full.prot.data <- cbind(data.SENS,data.RES)
+
+## metabolomics
+SENS.data <- merge(SENS.cell.info, met.df, by="CCLE_ID")
+SENS.data$stripped_cell_line_name <- NULL
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+RES.data <- merge(RES.cell.info, met.df, by="CCLE_ID")
+RES.data$stripped_cell_line_name <- NULL
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.full.met.data <- cbind(data.SENS,data.RES)
+
+#### Get smaller data sets for comparison to GSE31625
+### randomly sample 3 sensitive cell lines & 2 resistant cell lines
+sampled.SENS.CCLE_ID <- sample(SENS.CCLE_ID, 3)
+
+sampled.RES.CCLE_ID <- sample(RES.CCLE_ID, 2)
+
+### Get data for SENS and RES cells
+## transcriptomics
+SENS.data <- merge(SENS.cell.info[SENS.cell.info$CCLE_ID %in% 
+                                    sampled.SENS.CCLE_ID, ], transcr.df,
+                   by = "CCLE_ID")
+SENS.data$stripped_cell_line_name <- NULL
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+RES.data <- merge(RES.cell.info[RES.cell.info$CCLE_ID %in% 
+                                   sampled.RES.CCLE_ID, ], transcr.df,
+                  by = "CCLE_ID")
+RES.data$stripped_cell_line_name <- NULL
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.transcr.data <- cbind(data.SENS,data.RES)
+
+## proteomics
+SENS.data <- merge(SENS.cell.info[SENS.cell.info$CCLE_ID %in% 
+                                    sampled.SENS.CCLE_ID, ], prot.df,
+                   by = "CCLE_ID")
+SENS.data$stripped_cell_line_name <- NULL
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+RES.data <- merge(RES.cell.info[RES.cell.info$CCLE_ID %in% 
+                                  sampled.RES.CCLE_ID, ], prot.df,
+                  by = "CCLE_ID")
+RES.data$stripped_cell_line_name <- NULL
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.prot.data <- cbind(data.SENS,data.RES)
+
+## metabolomics
+SENS.data <- merge(SENS.cell.info[SENS.cell.info$CCLE_ID %in% 
+                                    sampled.SENS.CCLE_ID, ], met.df,
+                   by = "CCLE_ID")
+SENS.data$stripped_cell_line_name <- NULL
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+RES.data <- merge(RES.cell.info[RES.cell.info$CCLE_ID %in% 
+                                  sampled.RES.CCLE_ID, ], met.df,
+                  by = "CCLE_ID")
+RES.data$stripped_cell_line_name <- NULL
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.met.data <- cbind(data.SENS,data.RES)
+
+##### Step 3: GSE31625 (EGFR inhibitor) #####
+# load series and platform data from GEO
+gset <- getGEO("GSE31625", GSEMatrix =TRUE, AnnotGPL=TRUE)
+if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1
+gset <- gset[[idx]]
+
+# make proper column names to match toptable
+fvarLabels(gset) <- make.names(fvarLabels(gset))
+
+# group membership for all samples
+gsms <- paste0("X11111111XXXXXXXXX0000000XXXXXXXX0000X0000001111") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded
+sml <- strsplit(gsms, split="")[[1]]
+
+# filter out excluded samples (marked as "X")
+sel <- which(sml != "X")
+sml <- sml[sel]
+
+##### Step 4: GSE12790 (EGFR inhibitor) #####
+# load series and platform data from GEO
+gset <- getGEO("GSE12790", GSEMatrix =TRUE, AnnotGPL=TRUE)
+if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1
+gset <- gset[[idx]]
+
+# make proper column names to match toptable
+fvarLabels(gset) <- make.names(fvarLabels(gset))
+
+# group membership for all samples
+gsms <- paste0("XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX1XX",
+               "X0X11X1XX1X1X1XX1XX1X1110X1XX1XXX11X1XX0XX1XXXXX") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded
+sml <- strsplit(gsms, split="")[[1]]
+
+# filter out excluded samples (marked as "X")
+sel <- which(sml != "X")
+sml <- sml[sel]
+
+#### Get smaller data sets for comparison to GSE31625
+### randomly sample 3 sensitive cell lines & 2 resistant cell lines
+
+##### Step 5: run panSEA #####
+# IMPORTANT: each group must have the same # & position of samples across data sets
+# e.g. "Sensitive" samples must be in the same columns across input data.list
+# but "Resistant" could have different # as "Sensitive" hypothetically
+group.names = c("Sensitive", "Resistant")
+#### Step 5a: Fig2: 3 transcriptomic signatures of EGFRi sensitivity ####
+types <- c("GSE12790", "GSE31625", "Coldren et al")
+data.list <- list()
+group.samples <- list()
+
+Fig2.panSEA <- panSEA::panSEA(data.list, types, group.names = group.names,
+                              group.samples = group.samples)
+
+#### Step 5b: Fig3: transcriptomics, proteomics, and metabolomics signatures ####
+types <- c("transcriptomics", "proteomics", "metabolomics")
+data.list <- list()
+feature.names <- c("Gene", "Gene", "Metabolite")
+group.samples <- list()
+gmt.features <- list("msigdb_Homo sapiens_C2_CP:KEGG",
+                     "msigdb_Homo sapiens_C2_CP:KEGG",
+                     "hmdb")
+
+Fig3.panSEA <- panSEA::panSEA(data.list, types, feature.names, 
+                              group.names = group.names,
+                              group.samples = group.samples,
+                              gmt.features = gmt.features)
+
+#### Step 5c: Fig4: Fig3 but only querying non-small cell lung cancer cell line data ####
+lung.samples <- cell.line.info[cell.line.info$tissue == "lung", ] # check column, lung filter
+lung.RNAseq <- RNAseq[RNAseq$CCLE_ID %in% lung.samples, ]
+expression <- list(lung.RNAseq, lung.RNAseq, lung.RNAseq)
+
+Fig3.panSEA <- panSEA::panSEA(data.list, types, feature.names, 
+                              group.names = group.names,
+                              group.samples = group.samples,
+                              gmt.features = gmt.features,
+                              expression = expression)
diff --git a/Examples/panSEA_examples_1group.R b/Examples/panSEA_examples_1group.R
new file mode 100644
index 0000000..a5fa71d
--- /dev/null
+++ b/Examples/panSEA_examples_1group.R
@@ -0,0 +1,569 @@
+# panSEA examples
+# Author: Belinda B. Garana (BG)
+# Date created: 2023-12-21
+# Last edit: BG 2023-12-21
+
+# To recreate: press run through the whole script
+# Overview
+# 1 - import CCLE data
+# 2 - import Coldren et al. data & run differential expression analysis
+# 3 - import GSE31625 data & run differential expression analysis
+# 4 - import GSE12790 data & run differential expression analysis
+# 5 - run panSEA
+
+rm(list=ls(all=TRUE))
+library(plyr);library(dplyr);library(GSA);library(panSEA);library(GEOquery)
+base.path <- "~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/"
+setwd(paste0(base.path, "Inputs"))
+
+# function to save results
+savePanSEA <- function(panSEA.results, fig.folder) {
+  # set file names
+  DMEA.files <- list("DMEA_results.csv" =
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$results,
+                     "DMEA_mean_results.csv" =
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$mean.results,
+                     "DMEA_correlation_matrix.pdf" =
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$corr.matrix,
+                     "DMEA_venn_diagram.pdf" = 
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$venn.diagram,
+                     "DMEA_dot_plot.pdf" =
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$dot.plot,
+                     "DMEA_interactive_network.graph.html" =
+                       panSEA.results$mDMEA.network[[1]]$interactive)
+  GSEA.files <- list("GSEA_results.csv" =
+                       panSEA.results$mGSEA.results[[1]]$compiled.results$results,
+                     "GSEA_mean_results.csv" =
+                       panSEA.results$mGSEA.results[[1]]$compiled.results$mean.results,
+                     "GSEA_correlation_matrix.pdf" =
+                       panSEA.results$mGSEA.results[[1]]$compiled.results$corr.matrix,
+                     "GSEA_venn_diagram.pdf" = 
+                       panSEA.results$mGSEA.results[[1]]$compiled.results$venn.diagram,
+                     "GSEA_dot_plot.pdf" =
+                       panSEA.results$mGSEA.results[[1]]$compiled.results$dot.plot,
+                     "GSEA_interactive_network.graph.html" =
+                       panSEA.results$mGSEA.network[[1]]$interactive)
+  all.files <- list('GSEA' = GSEA.files,
+                    'DMEA' = DMEA.files)
+  
+  base.path <- getwd()
+  dir.create(fig.folder)
+  setwd(fig.folder)
+  for (i in 1:length(all.files)) {
+    # create local folder for subset of results
+    setwd(paste0(base.path, "/", fig.folder))
+    dir.create(names(all.files)[i])
+    setwd(names(all.files)[i])
+    
+    # save results locally
+    temp.files <- all.files[[i]]
+    
+    CSV.files <- names(temp.files)[grepl(".csv", names(temp.files))]
+    for (j in 1:length(CSV.files)) {
+      write.csv(temp.files[[CSV.files[j]]], CSV.files[j], row.names = FALSE)
+    }
+    
+    PDF.files <- names(temp.files)[grepl(".pdf", names(temp.files))]
+    for (j in 1:length(PDF.files)) {
+      ggplot2::ggsave(PDF.files[j], temp.files[[PDF.files[j]]], device = "pdf")
+    }
+    
+    HTML.files <- names(temp.files)[grepl(".html", names(temp.files))]
+    if (length(HTML.files) > 0) {
+      for (j in 1:length(HTML.files)) {
+        visNetwork::visSave(temp.files[[HTML.files[j]]], HTML.files[j])
+      }
+    }
+  }
+  setwd(paste0(base.path, "/", fig.folder))
+  saveRDS(panSEA.results, paste0("panSEA_", fig.folder, ".rds"))
+}
+
+##### Step 1: Import CCLE data (PRISM drug AUC, drug moa gmt, RNAseq, proteomics, metabolomics) #####
+#### cell line info (CCLE 19Q4)
+cell.line.info <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/CCLE_sample_info.csv")
+cell.line.info$X <- NULL
+
+#### RNAseq (CCLE 19Q4) for 327 adherent cancer cell lines
+download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin", 
+              destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin"))
+load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin")
+download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin", 
+              destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin"))
+load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin")
+RNA.df <- rbind(RNA.first200, RNA.rest)
+RNA.first200 <- NULL
+RNA.rest <- NULL
+
+#### proteomics (CCLE from IMPROVE)
+#download.file("https://figshare.com/ndownloader/files/41466702", "proteomics.csv.gz")
+prot.df <- read.csv(gzfile("proteomics.csv.gz"),fileEncoding="UTF-16LE")
+
+allgenes = readr::read_csv("https://figshare.com/ndownloader/files/40576109")
+genes = allgenes|>
+  dplyr::select(gene_symbol,entrez_id)|>
+  dplyr::distinct()
+genes <- genes[genes$gene_symbol %in% colnames(RNA.df)[2:ncol(RNA.df)], ]
+
+allsamples = readr::read_csv('https://figshare.com/ndownloader/files/40576103')
+CCLE.samples <- dplyr::distinct(allsamples[allsamples$id_source == "CCLE",
+                                           c("other_id","improve_sample_id")])
+
+# merge prot.df with genes, samples to stop using improve IDs
+prot.df <- merge(prot.df, CCLE.samples)
+prot.df <- merge(prot.df, genes)
+prot.df$entrez_id <- NULL
+prot.df <- dplyr::distinct(prot.df)
+
+# convert to wide format for DMEA
+prot.df <- reshape2::dcast(prot.df, other_id ~ gene_symbol, mean,
+                                value.var = "proteomics")
+colnames(prot.df)[1] <- "CCLE_ID"
+
+#### metabolomics (CCLE)
+met.df <- read.csv(paste0("~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/",
+                          "Inputs/CCLE_metabolomics_20190502.csv"))
+met.df$DepMap_ID <- NULL
+
+Sys.setenv("VROOM_CONNECTION_SIZE"=300000) # increase connection buffer size
+setwd(base.path)
+##### Step 2: Coldren et al (EGFR inhibitor ) #####
+### Identify sensitive (SENS) or resistant (RES) cells
+### based on Coldren et al, 2006 paper
+SENS.cells <- c("NCIH358","NCIH322C","CALU3","NCIH1334","NCIH1648",
+                "HCC827","HCC78","NCIH2126","HCC193","HCC95",
+                "NCIH3255","HCC4006","NCIH2009","NCIH1650","NCIH820","NCIH1975")
+RES.cells <- c("NCIH125","NCIH1703","A549","NCIH157","NCIH460","NCIH520",
+               "HCC44","HCC15","NCIH157","NCIH1299","HCC2279")
+SENS.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% SENS.cells,] 
+SENS.stripped_cell_line_name <- SENS.cell.info$stripped_cell_line_name
+# 12 SENS cell lines: "HCC827", "NCIH1650", "HCC4006", "NCIH3255", "CALU3",
+# "HCC95", "HCC78", "NCIH1975", "NCIH1648", "NCIH2126", "NCIH358", "NCIH2009"
+
+RES.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% RES.cells,]
+RES.stripped_cell_line_name <- RES.cell.info$stripped_cell_line_name
+# 8 RES cell lines: "NCIH520", "NCIH460", "NCIH1299", "HCC44", "A549", 
+# "HCC2279", "NCIH1703", "HCC15"
+
+# Coldren.samples <- list(seq(2, length.out = length(SENS.stripped_cell_line_name)), 
+#                         seq((length(SENS.stripped_cell_line_name) + 2), 
+#                             length.out = length(RES.stripped_cell_line_name)))
+
+Coldren.sample.IDs <- CCLE.samples[CCLE.samples$other_id %in% 
+                                     c(SENS.cell.info$CCLE_Name,
+                                       RES.cell.info$CCLE_Name),]
+colnames(Coldren.sample.IDs)[1] <- "CCLE_Name" # change other_id to CCLE_Name
+Coldren.sample.IDs <- merge(Coldren.sample.IDs, cell.line.info)
+# Coldren.SENS.IDs <- Coldren.sample.IDs[Coldren.sample.IDs$CCLE_Name %in% 
+#                                          SENS.cell.info$CCLE_Name, 
+#                                        c("improve_sample_id", "CCLE_ID")]
+# Coldren.RES.IDs <- Coldren.sample.IDs[Coldren.sample.IDs$CCLE_Name %in% 
+#                                         RES.cell.info$CCLE_Name, 
+#                                       c("improve_sample_id", "CCLE_ID")]
+
+### Get data for SENS and RES cells
+## transcriptomics
+SENS.data <- RNA.df[RNA.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] 
+# 5 SENS cell lines: "NCIH1650_LUNG", "HCC95_LUNG", "NCIH1975_LUNG",
+# "NCIH1648_LUNG", "NCIH2126_LUNG"
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+
+RES.data <- RNA.df[RNA.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] 
+# 7 cell lines: "NCIH520_LUNG", "NCIH460_LUNG", "NCIH1299_LUNG", "HCC44_LUNG",
+# "A549_LUNG", "NCIH1703_LUNG", "HCC15_LUNG" 
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.transcr <- as.data.frame(cbind(data.SENS,data.RES))
+Coldren.transcr$Gene <- rownames(Coldren.transcr)
+Coldren.transcr <- Coldren.transcr[ , c("Gene", 
+                                        colnames(Coldren.transcr)[
+                                          1:(ncol(Coldren.transcr)-1)])]
+
+## proteomics
+SENS.data <- prot.df[prot.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] 
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+# 8 cell lines: "HCC827_LUNG", "HCC95_LUNG", "NCIH1650_LUNG", "NCIH1975_LUNG",
+# "NCIH2009_LUNG", "NCIH2126_LUNG", "NCIH3255_LUNG", "NCIH358_LUNG" 
+
+RES.data <- prot.df[prot.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] 
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+# 7 cell lines: "A549_LUNG", "HCC15_LUNG", "HCC44_LUNG", "NCIH1299_LUNG",
+# "NCIH1703_LUNG", "NCIH460_LUNG", "NCIH520_LUNG" 
+
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.prot <- as.data.frame(cbind(data.SENS,data.RES))
+Coldren.prot$Gene <- rownames(Coldren.prot)
+Coldren.prot <- Coldren.prot[ , c("Gene", 
+                                  colnames(Coldren.prot)[
+                                    1:(ncol(Coldren.prot)-1)])]
+
+## metabolomics
+SENS.data <- met.df[met.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] 
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+# 12 cell lines: "NCIH358_LUNG", "NCIH1650_LUNG", "HCC95_LUNG",
+# "NCIH3255_LUNG", "NCIH1648_LUNG", "NCIH1975_LUNG", "HCC78_LUNG",
+# "NCIH2126_LUNG", "HCC827_LUNG", "CALU3_LUNG", "NCIH2009_LUNG", "HCC4006_LUNG" 
+
+RES.data <- met.df[met.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] 
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+# 8 cell lines: "HCC2279_LUNG", "NCIH520_LUNG", "HCC15_LUNG", "NCIH460_LUNG",
+# "A549_LUNG", "HCC44_LUNG", "NCIH1703_LUNG", "NCIH1299_LUNG"
+
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.met <- as.data.frame(cbind(data.SENS,data.RES))
+Coldren.met$Metabolite <- rownames(Coldren.met)
+Coldren.met <- Coldren.met[ , c("Metabolite", 
+                                colnames(Coldren.met)[
+                                  1:(ncol(Coldren.met)-1)])]
+
+### run differential expression analysis
+### have to do this separately for each omics because they have different
+### numbers of SENS and RES samples
+## transcriptomics
+# group.samples <- list(seq(2, length.out = nrow(RNA.df[
+#   RNA.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ])), 
+#   seq((nrow(RNA.df[RNA.df$CCLE_ID %in% 
+#                          SENS.cell.info$CCLE_Name, ]) + 2), 
+#       length.out = nrow(met.df[met.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ])))
+group.samples <- list(RNA.df$CCLE_ID[RNA.df$CCLE_ID %in% 
+                                       SENS.cell.info$CCLE_Name],
+                      RNA.df$CCLE_ID[RNA.df$CCLE_ID %in% 
+                                       RES.cell.info$CCLE_Name])
+Coldren.transcr.DEGs <- panSEA::mDEG(list(Coldren.transcr), types = "Transcriptomics",
+                                     group.names = c("Sensitive", "Resistant"),
+                                     group.samples, "Gene")$all.results[[1]]
+write.csv(Coldren.transcr.DEGs, "Coldren_transcriptomics_DEGs_before_avg.csv", 
+          row.names = FALSE)
+Coldren.transcr.DEGs <- read.csv("Coldren_transcriptomics_DEGs_before_avg.csv")
+library(plyr);library(dplyr)
+Coldren.transcr <- ddply(Coldren.transcr.DEGs, .(Gene), summarise,
+                                    Log2FC = mean(Log2FC, na.rm=TRUE)) #prevent duplicate gene names
+write.csv(Coldren.transcr, "Coldren_transcriptomics_DEGs.csv", 
+          row.names = FALSE)
+Coldren.transcr <- read.csv("Coldren_transcriptomics_DEGs.csv")
+
+## proteomics
+group.samples <- list(prot.df$CCLE_ID[prot.df$CCLE_ID %in% 
+                                       SENS.cell.info$CCLE_Name],
+                      prot.df$CCLE_ID[prot.df$CCLE_ID %in% 
+                                       RES.cell.info$CCLE_Name])
+Coldren.prot.DEGs <- panSEA::mDEG(list(Coldren.prot), types = "Proteomics",
+                                     group.names = c("Sensitive", "Resistant"),
+                                     group.samples, "Gene")$all.results[[1]]
+write.csv(Coldren.prot.DEGs, "Coldren_proteomics_DEGs_before_avg.csv", 
+          row.names = FALSE)
+Coldren.prot.DEGs <- read.csv("Coldren_proteomics_DEGs_before_avg.csv")
+Coldren.prot <- plyr::ddply(Coldren.prot.DEGs, .(Gene), summarise,
+                                     Log2FC = mean(Log2FC, na.rm=TRUE)) #prevent duplicate gene names
+write.csv(Coldren.prot, "Coldren_proteomics_DEGs.csv", 
+          row.names = FALSE)
+Coldren.prot <- read.csv("Coldren_proteomics_DEGs.csv")
+
+## metabolomics
+group.samples <- list(met.df$CCLE_ID[met.df$CCLE_ID %in% 
+                                       SENS.cell.info$CCLE_Name],
+                      met.df$CCLE_ID[met.df$CCLE_ID %in% 
+                                       RES.cell.info$CCLE_Name])
+Coldren.met.DEGs <- panSEA::mDEG(list(Coldren.met), types = "Metabolomics",
+                                     group.names = c("Sensitive", "Resistant"),
+                                     group.samples, "Metabolite")$all.results[[1]]
+write.csv(Coldren.met.DEGs, "Coldren_metabolomics_DEGs_before_avg.csv", 
+          row.names = FALSE)
+Coldren.met.DEGs <- read.csv("Coldren_metabolomics_DEGs_before_avg.csv")
+Coldren.met <- plyr::ddply(Coldren.met.DEGs, .(Metabolite), summarise,
+                                 Log2FC = mean(Log2FC, na.rm=TRUE)) #prevent duplicate gene names
+write.csv(Coldren.met, "Coldren_metabolomics_DEGs.csv", 
+          row.names = FALSE)
+Coldren.met <- read.csv("Coldren_metabolomics_DEGs.csv")
+
+##### Step 3: GSE31625 (EGFR inhibitor) #####
+# load series and platform data from GEO
+gset <- getGEO("GSE31625", GSEMatrix =TRUE, AnnotGPL=TRUE)
+if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1
+gset <- gset[[idx]]
+
+# make proper column names to match toptable
+fvarLabels(gset) <- make.names(fvarLabels(gset))
+
+# group membership for all samples
+gsms <- paste0("X11111111XXXXXXXXX0000000XXXXXXXX0000X0000001111") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded
+sml <- strsplit(gsms, split="")[[1]]
+
+# filter out excluded samples (marked as "X")
+sel <- which(sml != "X")
+sml <- sml[sel]
+gset <- gset[ ,sel]
+
+### run differential expression analysis
+# log2 transformation
+ex <- exprs(gset)
+qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), na.rm=T))
+LogC <- (qx[5] > 100) ||
+  (qx[6]-qx[1] > 50 && qx[2] > 0)
+if (LogC) { ex[which(ex <= 0)] <- NaN
+exprs(gset) <- log2(ex) }
+SENS.expr <- as.data.frame(exprs(gset[,which(sml==0)]))
+RES.expr <- as.data.frame(exprs(gset[,which(sml==1)]))
+
+# assign samples to groups and set up design matrix
+gs <- factor(sml)
+groups <- make.names(c("test","test2"))
+levels(gs) <- groups
+gset$group <- gs
+design <- model.matrix(~group + 0, gset)
+colnames(design) <- levels(gs)
+
+fit <- limma::lmFit(gset, design)  # fit linear model
+
+# set up contrasts of interest and recalculate model coefficients
+cts <- paste(groups[1], groups[2], sep="-")
+cont.matrix <- limma::makeContrasts(contrasts=cts, levels=design)
+fit2 <- limma::contrasts.fit(fit, cont.matrix)
+
+# compute statistics and table of top significant genes
+fit2 <- limma::eBayes(fit2, 0.01)
+tT <- limma::topTable(fit2, adjust="fdr", sort.by="B", number=nrow(fit2))
+tT <- subset(tT, select=c("ID","adj.P.Val","P.Value","t","B","logFC","Gene.symbol","Gene.title")) # 22,215 genes
+tT.noblanks <- tT[tT$Gene.symbol!="",] # 21,146 genes
+colnames(tT.noblanks)[6] <- "Log2FC"
+colnames(tT.noblanks)[7] <- "Gene"
+GSE31625.DEGs <- tT.noblanks
+GSE31625.DEGs$Log2Transformed <- LogC
+write.csv(GSE31625.DEGs, "GSE31625_transcriptomics_DEGs_before_avg.csv", 
+          row.names = FALSE)
+GSE31625.DEGs <- read.csv("GSE31625_transcriptomics_DEGs_before_avg.csv")
+GSE31625 <- plyr::ddply(GSE31625.DEGs, .(Gene), summarise,
+                                 Log2FC = mean(Log2FC, na.rm=TRUE)) #prevent duplicate gene names
+write.csv(GSE31625, "GSE31625_transcriptomics_DEGs.csv", 
+          row.names = FALSE)
+GSE31625 <- read.csv("GSE31625_transcriptomics_DEGs.csv")
+
+# GSE31625.DEGs <- panSEA::mDEG(GSE31625, types = "Transcriptomics", 
+#                              group.names = c("Sensitive", "Resistant"),
+#                              list(sml[which(sml == 0)], sml[which(sml == 1)])
+#                              )$all.results
+
+##### Step 4: GSE12790 (EGFR inhibitor) #####
+# load series and platform data from GEO
+gset <- getGEO("GSE12790", GSEMatrix =TRUE, AnnotGPL=TRUE)
+if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1
+gset <- gset[[idx]]
+
+# make proper column names to match toptable
+fvarLabels(gset) <- make.names(fvarLabels(gset))
+
+# group membership for all samples
+gsms <- paste0("XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX1XX",
+               "X0X11X1XX1X1X1XX1XX1X1110X1XX1XXX11X1XX0XX1XXXXX") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded
+sml <- strsplit(gsms, split="")[[1]]
+
+# filter out excluded samples (marked as "X")
+sel <- which(sml != "X")
+sml <- sml[sel]
+gset <- gset[ ,sel]
+
+### run differential expression analysis
+# log2 transformation
+ex <- exprs(gset)
+qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), na.rm=T))
+LogC <- (qx[5] > 100) ||
+  (qx[6]-qx[1] > 50 && qx[2] > 0)
+if (LogC) { ex[which(ex <= 0)] <- NaN
+exprs(gset) <- log2(ex) }
+
+# assign samples to groups and set up design matrix
+gs <- factor(sml)
+groups <- make.names(c("test","test2"))
+levels(gs) <- groups
+gset$group <- gs
+design <- model.matrix(~group + 0, gset)
+colnames(design) <- levels(gs)
+
+fit <- limma::lmFit(gset, design)  # fit linear model
+
+# set up contrasts of interest and recalculate model coefficients
+cts <- paste(groups[1], groups[2], sep="-")
+cont.matrix <- limma::makeContrasts(contrasts=cts, levels=design)
+fit2 <- limma::contrasts.fit(fit, cont.matrix)
+
+# compute statistics and table of top significant genes
+fit2 <- limma::eBayes(fit2, 0.01)
+tT <- limma::topTable(fit2, adjust="fdr", sort.by="B", number=nrow(fit2))
+
+tT <- subset(tT, select=c("ID","adj.P.Val","P.Value","t","B","logFC","Gene.symbol","Gene.title")) # 54,675 genes
+tT.noblanks <- tT[tT$Gene.symbol!="",] #45,118 genes
+colnames(tT.noblanks)[6] <- "Log2FC"
+colnames(tT.noblanks)[7] <- "Gene"
+GSE12790.DEGs <- tT.noblanks
+GSE12790.DEGs$Log2Transformed <- LogC
+write.csv(GSE12790.DEGs, "GSE12790_transcriptomics_DEGs_before_avg.csv", 
+          row.names = FALSE)
+GSE12790.DEGs <- read.csv("GSE12790_transcriptomics_DEGs_before_avg.csv")
+GSE12790 <- dplyr::distinct(plyr::ddply(GSE12790.DEGs, .(Gene), summarise,
+                             Log2FC = mean(Log2FC, na.rm=TRUE))) #prevent duplicate gene names
+write.csv(GSE12790, "GSE12790_transcriptomics_DEGs.csv", 
+          row.names = FALSE)
+GSE12790 <- read.csv("GSE12790_transcriptomics_DEGs.csv")
+
+# GSE12790.DEGs <- panSEA::mDEG(GSE12790, types = "Transcriptomics", 
+#                               group.names = c("Sensitive", "Resistant"),
+#                               list(sml[which(sml == 0)], sml[which(sml == 1)])
+#                               )$all.results
+
+##### Step 5: run panSEA #####
+# IMPORTANT: each group must have the same # & position of samples across data sets
+# e.g. "Sensitive" samples must be in the same columns across input data.list
+# but "Resistant" could have different # as "Sensitive" hypothetically
+group.names <- "Sensitive vs. Resistant"
+group.samples <- 2
+
+# get gene set info
+msigdb.info <- msigdbr::msigdbr("Homo sapiens", "C2", "CP:KEGG")
+
+# extract necessary info into data frame
+msigdb.info <- as.data.frame(msigdb.info[, c(
+  "gene_symbol",
+  "gs_name",
+  "gs_description"
+)])
+
+gene.gmt <- DMEA::as_gmt(
+  msigdb.info, "gene_symbol", "gs_name", min.per.set = 6,
+  descriptions = "gs_description")
+saveRDS(gene.gmt, "gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds")
+gene.gmt <- readRDS("Inputs/gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds")
+
+# get metabolite set info
+# based on hmdb v5.0 downloaded 20231220: https://hmdb.ca/downloads 
+hmdb <- XML::xmlToDataFrame("hmdb_metabolites.xml")
+saveRDS(hmdb, "hmdb_metabolites_dataframe.rds")
+hmdb <- readRDS("hmdb_metabolites_dataframe.rds")
+#hmdb$class <- sub(".*belongs to the class of organic compounds known as (.+)\\..*", "\\1", hmdb$taxonomy)
+hmdb$class <- NA
+hmdb$class <- stringr::str_match(hmdb$taxonomy, "belongs to the class of organic compounds known as\\s*(.*?)\\s*\\. ")[ , 2]
+#inorganic.hmdb <- hmdb[is.na(hmdb$class), ] # 72291 / 217920
+hmdb[is.na(hmdb$class), ]$class <- 
+  stringr::str_match(
+    hmdb[is.na(hmdb$class), ]$taxonomy, 
+    "belongs to the class of inorganic compounds known as\\s*(.*?)\\s*\\. ")[ , 2]
+#unclassified.hmdb <- hmdb[is.na(hmdb$class), ] # 71984 / 217920
+#nonblank.unclassified.hmdb <- unclassified.hmdb[unclassified.hmdb$taxonomy != "\n  ", ] # 1 / 71984
+hmdb[is.na(hmdb$class), ]$class <- 
+  stringr::str_match(
+    hmdb[is.na(hmdb$class), ]$taxonomy, 
+    "belongs to the class of chemical entities known as\\s*(.*?)\\s*\\. ")[ , 2]
+#unclassified.hmdb <- hmdb[is.na(hmdb$class), ] # 71983 / 217920
+saveRDS(hmdb, "hmdb_metabolites_dataframe_with_class.rds")
+hmdb <- readRDS("hmdb_metabolites_dataframe_with_class.rds")
+hmdb <- dplyr::distinct(na.omit(hmdb[ , c("name", "class")])) # 145937 metabolites
+
+met.gmt <- DMEA::as_gmt(hmdb, "name", "class", min.per.set = 6)
+saveRDS(met.gmt, "gmt_HMDB.rds")
+
+hmdb <- readRDS("hmdb_metabolites_dataframe_with_class.rds")
+hmdb <- dplyr::distinct(na.omit(hmdb[ , c("name", "class")])) # 145937 metabolites
+# hmdb.wide <- reshape2::dcast(hmdb, class ~ name)
+# hmdb.match <- colnames(hmdb.wide)[tolower(colnames(hmdb.wide)) %in% colnames(met.df)[2:ncol(met.df)]] # 46 / 225
+hmdb.CCLE <- hmdb[tolower(hmdb$name) %in% colnames(met.df)[2:ncol(met.df)], ] # 46 / 225
+hmdb.CCLE$name <- lapply(hmdb.CCLE$name, tolower)
+met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 6)
+saveRDS(met.gmt, "gmt_HMDB_in_CCLE.rds")
+hmdb <- NULL
+met.gmt <- readRDS("gmt_HMDB_in_CCLE.rds")
+
+# increase # of groups with 6+ metabolites
+hmdb.CCLE[grep("alpha", hmdb.CCLE$class), ]$class <- "alpha amino acids"
+met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 6)
+saveRDS(met.gmt, "gmt_HMDB_in_CCLE_2sets.rds")
+met.gmt <- readRDS("Inputs/gmt_HMDB_in_CCLE_2sets.rds")
+
+# met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 4)
+# saveRDS(met.gmt, "gmt_HMDB_in_CCLE_4minperset.rds")
+
+#### Step 5a: Fig2: 3 transcriptomic signatures of EGFRi sensitivity ####
+types <- c("GSE12790", "GSE31625", "Coldren et al")
+data.list <- list("GSE12790" = GSE12790, 
+                  "GSE31625" = GSE31625, 
+                  "Coldren et al" = Coldren.transcr)
+gmt.features <- list(gene.gmt, gene.gmt, gene.gmt)
+expression <- list(RNA.df, RNA.df, RNA.df)
+
+Fig2.panSEA <- panSEA::panSEA(data.list, types, group.names = group.names,
+                              group.samples = group.samples, gmt.features = gmt.features,
+                              expression = expression)
+# save results
+fig.folder <- "Fig2"
+savePanSEA(Fig2.panSEA, fig.folder)
+Fig2.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+Fig2.panSEA <- NULL # make space to process next analysis
+
+#### Step 5b: Fig3: transcriptomics, proteomics, and metabolomics signatures ####
+types <- c("transcriptomics", "proteomics", "metabolomics")
+data.list <- list(Coldren.transcr, Coldren.prot, Coldren.met)
+feature.names <- c("Gene", "Gene", "Metabolite")
+gmt.features <- list(gene.gmt, gene.gmt, met.gmt)
+prot.df.noNA <- prot.df[, colSums(is.na(prot.df)) == 0] # 5466 gene names
+expression <- list(RNA.df, prot.df.noNA, met.df)
+
+Fig3.panSEA <- panSEA::panSEA(data.list, types, feature.names, 
+                              group.names = group.names,
+                              group.samples = group.samples,
+                              gmt.features = gmt.features,
+                              expression = expression)
+# proteomics: CCLE prot doesn't contain any of the gene symbols provided (?)
+# had to skip line 15 (na.omit for expr) of DMEA::WV
+# but then had: Error: id variables not found in data: WV
+# it's because the CCLE need to have full coverage of the input gene names
+
+# save results
+setwd(base.path)
+savePanSEA(Fig3.panSEA, "Fig3")
+Fig3.panSEA <- NULL # make space to process next analysis
+
+#### Step 5c: Fig4: Fig3 but only querying non-small cell lung cancer cell line data ####
+NSCLC.samples <- cell.line.info[cell.line.info$lineage_subtype == "NSCLC", ] # 158 CCLE
+NSCLC.RNA.df <- RNA.df[RNA.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 51 CCLE
+NSCLC.prot.df <- prot.df[prot.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 63 CCLE
+NSCLC.met.df <- met.df[met.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 122 CCLE
+NSCLC.prot.df.noNA <- NSCLC.prot.df[, colSums(is.na(NSCLC.prot.df)) == 0] # 5729 gene names
+expression <- list(NSCLC.RNA.df, NSCLC.prot.df.noNA, NSCLC.met.df)
+
+Fig4.panSEA <- panSEA::panSEA(data.list, types, feature.names, 
+                              group.names = group.names,
+                              group.samples = group.samples,
+                              gmt.features = gmt.features,
+                              expression = expression)
+
+# save results
+setwd(base.path)
+savePanSEA(Fig4.panSEA, "Fig4")
+Fig4.panSEA <- NULL # make space to process next analysis
+
+#### Step 5d: Fig5: Fig3 but only querying lung cancer cell line data ####
+lung.samples <- cell.line.info[cell.line.info$lineage == "lung", ] # 273 CCLE
+lung.RNA.df <- RNA.df[RNA.df$CCLE_ID %in% lung.samples$CCLE_Name, ] # 63 CCLE
+lung.prot.df <- prot.df[prot.df$CCLE_ID %in% lung.samples$CCLE_Name, ] # 78 CCLE
+lung.met.df <- met.df[met.df$CCLE_ID %in% lung.samples$CCLE_Name, ] # 182 CCLE
+lung.prot.df.noNA <- lung.prot.df[, colSums(is.na(lung.prot.df)) == 0] # 5565 gene names
+expression <- list(lung.RNA.df, lung.prot.df.noNA, lung.met.df)
+
+Fig5.panSEA <- panSEA::panSEA(data.list, types, feature.names, 
+                              group.names = group.names,
+                              group.samples = group.samples,
+                              gmt.features = gmt.features,
+                              expression = expression)
+
+# save results
+setwd(base.path)
+savePanSEA(Fig5.panSEA, "Fig5")
+Fig5.panSEA <- NULL # make space to process next analysis
diff --git a/Examples/panSEA_examples_cell_corr.R b/Examples/panSEA_examples_cell_corr.R
new file mode 100644
index 0000000..5ef65c8
--- /dev/null
+++ b/Examples/panSEA_examples_cell_corr.R
@@ -0,0 +1,1057 @@
+# panSEA examples
+# Author: Belinda B. Garana (BG)
+# Date created: 2023-12-21
+# Last edit: BG 2023-12-21
+
+# To recreate: press run through the whole script
+# Overview
+# 1 - import CCLE data
+# 2 - import Coldren et al. data & run differential expression analysis
+# 3 - import GSE31625 data & run differential expression analysis
+# 4 - import GSE12790 data & run differential expression analysis
+# 5 - run panSEA with DMEA_cell_corr
+# 6 - run panSEA with DMEA (WV)
+
+rm(list=ls(all=TRUE))
+library(plyr);library(dplyr);library(GSA);library(panSEA);library(GEOquery)
+base.path <- "~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/"
+setwd(paste0(base.path, "Inputs"))
+
+# function to save results
+savePanSEA <- function(panSEA.results, fig.folder, GSEA = TRUE, RDS = TRUE) {
+  # set file names
+  DMEA.files <- list("DMEA_results.csv" =
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$results,
+                     "DMEA_mean_results.csv" =
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$mean.results,
+                     "DMEA_correlation_matrix.pdf" =
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$corr.matrix,
+                     "DMEA_venn_diagram.pdf" = 
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$venn.diagram,
+                     "DMEA_dot_plot.pdf" =
+                       panSEA.results$mDMEA.results[[1]]$compiled.results$dot.plot,
+                     "DMEA_interactive_network.graph.html" =
+                       panSEA.results$mDMEA.network[[1]]$interactive)
+  
+  if (GSEA) {
+    GSEA.files <- list("GSEA_results.csv" =
+                         panSEA.results$mGSEA.results[[1]]$compiled.results$results,
+                       "GSEA_mean_results.csv" =
+                         panSEA.results$mGSEA.results[[1]]$compiled.results$mean.results,
+                       "GSEA_correlation_matrix.pdf" =
+                         panSEA.results$mGSEA.results[[1]]$compiled.results$corr.matrix,
+                       "GSEA_venn_diagram.pdf" = 
+                         panSEA.results$mGSEA.results[[1]]$compiled.results$venn.diagram,
+                       "GSEA_dot_plot.pdf" =
+                         panSEA.results$mGSEA.results[[1]]$compiled.results$dot.plot,
+                       "GSEA_interactive_network.graph.html" =
+                         panSEA.results$mGSEA.network[[1]]$interactive)
+    all.files <- list('GSEA' = GSEA.files,
+                      'DMEA' = DMEA.files)
+  } else {
+    all.files <- list('DMEA' = DMEA.files)
+  }
+  
+  base.path <- getwd()
+  dir.create(fig.folder)
+  setwd(fig.folder)
+  for (i in 1:length(all.files)) {
+    # create local folder for subset of results
+    setwd(paste0(base.path, "/", fig.folder))
+    dir.create(names(all.files)[i])
+    setwd(names(all.files)[i])
+    
+    # save results locally
+    temp.files <- all.files[[i]]
+    
+    CSV.files <- names(temp.files)[grepl(".csv", names(temp.files))]
+    for (j in 1:length(CSV.files)) {
+      write.csv(temp.files[[CSV.files[j]]], CSV.files[j], row.names = FALSE)
+    }
+    
+    PDF.files <- names(temp.files)[grepl(".pdf", names(temp.files))]
+    for (j in 1:length(PDF.files)) {
+      ggplot2::ggsave(PDF.files[j], temp.files[[PDF.files[j]]], device = "pdf")
+    }
+    
+    HTML.files <- names(temp.files)[grepl(".html", names(temp.files))]
+    if (length(HTML.files) > 0) {
+      for (j in 1:length(HTML.files)) {
+        visNetwork::visSave(temp.files[[HTML.files[j]]], HTML.files[j])
+      }
+    }
+  }
+  setwd(paste0(base.path, "/", fig.folder))
+  if (RDS) {
+    saveRDS(panSEA.results, paste0("panSEA_", fig.folder, ".rds"))
+  }
+}
+
+##### Step 1: Import CCLE data (PRISM drug AUC, drug moa gmt, RNAseq, proteomics, metabolomics) #####
+#### cell line info (CCLE 19Q4)
+cell.line.info <- read.csv(file="https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/CCLE_sample_info.csv")
+cell.line.info$X <- NULL
+
+#### RNAseq (CCLE 19Q4) for 327 adherent cancer cell lines
+download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin", 
+              destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin"))
+load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin")
+download.file("https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin", 
+              destfile = paste0(getwd(),"/Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin"))
+load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin")
+RNA.df <- rbind(RNA.first200, RNA.rest)
+RNA.first200 <- NULL
+RNA.rest <- NULL
+
+#### proteomics (CCLE from IMPROVE)
+download.file("https://figshare.com/ndownloader/files/41466702", "proteomics.csv.gz")
+prot.df <- read.csv(gzfile("proteomics.csv.gz"),fileEncoding="UTF-16LE")
+
+allgenes = readr::read_csv("https://figshare.com/ndownloader/files/40576109")
+genes = allgenes|>
+  dplyr::select(gene_symbol,entrez_id)|>
+  dplyr::distinct()
+genes <- genes[genes$gene_symbol %in% colnames(RNA.df)[2:ncol(RNA.df)], ]
+
+allsamples = readr::read_csv('https://figshare.com/ndownloader/files/40576103')
+CCLE.samples <- dplyr::distinct(allsamples[allsamples$id_source == "CCLE",
+                                           c("other_id","improve_sample_id")])
+
+# merge prot.df with genes, samples to stop using improve IDs
+prot.df <- merge(prot.df, CCLE.samples)
+prot.df <- merge(prot.df, genes)
+prot.df$entrez_id <- NULL
+prot.df <- dplyr::distinct(prot.df)
+
+# convert to wide format for DMEA
+prot.df <- reshape2::dcast(prot.df, other_id ~ gene_symbol, mean,
+                                value.var = "proteomics")
+colnames(prot.df)[1] <- "CCLE_ID"
+
+#### metabolomics (CCLE)
+met.df <- read.csv(paste0("~/OneDrive - PNNL/Documents/GitHub/panSEA/Examples/",
+                          "Inputs/CCLE_metabolomics_20190502.csv"))
+met.df$DepMap_ID <- NULL
+
+Sys.setenv("VROOM_CONNECTION_SIZE"=300000) # increase connection buffer size
+setwd(base.path)
+##### Step 2: Coldren et al (EGFR inhibitor ) #####
+### Identify sensitive (SENS) or resistant (RES) cells
+### based on Coldren et al, 2006 paper
+SENS.cells <- c("NCIH358","NCIH322C","CALU3","NCIH1334","NCIH1648",
+                "HCC827","HCC78","NCIH2126","HCC193","HCC95",
+                "NCIH3255","HCC4006","NCIH2009","NCIH1650","NCIH820","NCIH1975")
+RES.cells <- c("NCIH125","NCIH1703","A549","NCIH157","NCIH460","NCIH520",
+               "HCC44","HCC15","NCIH157","NCIH1299","HCC2279")
+SENS.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% SENS.cells,] 
+SENS.stripped_cell_line_name <- SENS.cell.info$stripped_cell_line_name
+# 12 SENS cell lines: "HCC827", "NCIH1650", "HCC4006", "NCIH3255", "CALU3",
+# "HCC95", "HCC78", "NCIH1975", "NCIH1648", "NCIH2126", "NCIH358", "NCIH2009"
+
+RES.cell.info <- cell.line.info[cell.line.info$stripped_cell_line_name %in% RES.cells,]
+RES.stripped_cell_line_name <- RES.cell.info$stripped_cell_line_name
+# 8 RES cell lines: "NCIH520", "NCIH460", "NCIH1299", "HCC44", "A549", 
+# "HCC2279", "NCIH1703", "HCC15"
+
+# Coldren.samples <- list(seq(2, length.out = length(SENS.stripped_cell_line_name)), 
+#                         seq((length(SENS.stripped_cell_line_name) + 2), 
+#                             length.out = length(RES.stripped_cell_line_name)))
+
+Coldren.sample.IDs <- CCLE.samples[CCLE.samples$other_id %in% 
+                                     c(SENS.cell.info$CCLE_Name,
+                                       RES.cell.info$CCLE_Name),]
+colnames(Coldren.sample.IDs)[1] <- "CCLE_Name" # change other_id to CCLE_Name
+Coldren.sample.IDs <- merge(Coldren.sample.IDs, cell.line.info)
+# Coldren.SENS.IDs <- Coldren.sample.IDs[Coldren.sample.IDs$CCLE_Name %in% 
+#                                          SENS.cell.info$CCLE_Name, 
+#                                        c("improve_sample_id", "CCLE_ID")]
+# Coldren.RES.IDs <- Coldren.sample.IDs[Coldren.sample.IDs$CCLE_Name %in% 
+#                                         RES.cell.info$CCLE_Name, 
+#                                       c("improve_sample_id", "CCLE_ID")]
+
+### Get data for SENS and RES cells
+## transcriptomics
+SENS.data <- RNA.df[RNA.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] 
+# 5 SENS cell lines: "NCIH1650_LUNG", "HCC95_LUNG", "NCIH1975_LUNG",
+# "NCIH1648_LUNG", "NCIH2126_LUNG"
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+
+RES.data <- RNA.df[RNA.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] 
+# 7 cell lines: "NCIH520_LUNG", "NCIH460_LUNG", "NCIH1299_LUNG", "HCC44_LUNG",
+# "A549_LUNG", "NCIH1703_LUNG", "HCC15_LUNG" 
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.transcr <- as.data.frame(cbind(data.SENS,data.RES))
+Coldren.transcr$Gene <- rownames(Coldren.transcr)
+Coldren.transcr <- Coldren.transcr[ , c("Gene", 
+                                        colnames(Coldren.transcr)[
+                                          1:(ncol(Coldren.transcr)-1)])]
+
+# compile data into list for panSEA input
+all.Coldren.CCLE_IDs <- colnames(Coldren.transcr)[2:ncol(Coldren.transcr)]
+all.Coldren.names <- c("H1650", "HCC95", "H1975", "H1648", "H2126", "H520", 
+                       "H460", "H1299", "HCC44", "A549", "H1703", "HCC15")
+Coldren <- list()
+for (i in 2:ncol(Coldren.transcr)) {
+  temp.df <- Coldren.transcr[ , c(1, i)]
+  colnames(temp.df)[2] <- "Input"
+  Coldren[[all.Coldren.names[i-1]]] <- temp.df
+}
+
+## proteomics
+SENS.data <- prot.df[prot.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] 
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+# 8 cell lines: "HCC827_LUNG", "HCC95_LUNG", "NCIH1650_LUNG", "NCIH1975_LUNG",
+# "NCIH2009_LUNG", "NCIH2126_LUNG", "NCIH3255_LUNG", "NCIH358_LUNG" 
+
+RES.data <- prot.df[prot.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] 
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+# 7 cell lines: "A549_LUNG", "HCC15_LUNG", "HCC44_LUNG", "NCIH1299_LUNG",
+# "NCIH1703_LUNG", "NCIH460_LUNG", "NCIH520_LUNG" 
+
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.prot <- as.data.frame(cbind(data.SENS,data.RES))
+Coldren.prot$Gene <- rownames(Coldren.prot)
+Coldren.prot <- Coldren.prot[ , c("Gene", 
+                                  colnames(Coldren.prot)[
+                                    1:(ncol(Coldren.prot)-1)])]
+
+all.Coldren.prot.CCLE_IDs <- colnames(Coldren.prot)[2:ncol(Coldren.prot)]
+all.Coldren.prot.names <- c("HCC827", "HCC95", "H1650", "H1975", "H2009",
+                            "H2126", "H3255", "H358", "A549", "HCC15", "HCC44",
+                            "H1299", "H1703", "H460", "H520")
+# compile data into list for panSEA input
+Coldren.prot.list <- list()
+for (i in 2:ncol(Coldren.prot)) {
+  temp.df <- Coldren.prot[ , c(1, i)]
+  colnames(temp.df)[2] <- "Input"
+  Coldren.prot.list[[all.Coldren.prot.names[i-1]]] <- temp.df
+}
+
+## metabolomics
+SENS.data <- met.df[met.df$CCLE_ID %in% SENS.cell.info$CCLE_Name, ] 
+rownames(SENS.data) <- SENS.data$CCLE_ID
+SENS.data$CCLE_ID <- NULL
+# 12 cell lines: "NCIH358_LUNG", "NCIH1650_LUNG", "HCC95_LUNG",
+# "NCIH3255_LUNG", "NCIH1648_LUNG", "NCIH1975_LUNG", "HCC78_LUNG",
+# "NCIH2126_LUNG", "HCC827_LUNG", "CALU3_LUNG", "NCIH2009_LUNG", "HCC4006_LUNG" 
+
+RES.data <- met.df[met.df$CCLE_ID %in% RES.cell.info$CCLE_Name, ] 
+rownames(RES.data) <- RES.data$CCLE_ID
+RES.data$CCLE_ID <- NULL
+# 8 cell lines: "HCC2279_LUNG", "NCIH520_LUNG", "HCC15_LUNG", "NCIH460_LUNG",
+# "A549_LUNG", "HCC44_LUNG", "NCIH1703_LUNG", "NCIH1299_LUNG"
+
+data.SENS <- t(SENS.data)
+data.RES <- t(RES.data)
+Coldren.met <- as.data.frame(cbind(data.SENS,data.RES))
+Coldren.met$Metabolite <- rownames(Coldren.met)
+Coldren.met <- Coldren.met[ , c("Metabolite", 
+                                colnames(Coldren.met)[
+                                  1:(ncol(Coldren.met)-1)])]
+
+all.Coldren.met.CCLE_IDs <- colnames(Coldren.met)[2:ncol(Coldren.met)]
+all.Coldren.met.names <- c("H358", "H1650", "HCC95", "H3255", "H1648",
+                           "H1975", "HCC78", "H2126", "HCC827", "CALU3", 
+                           "H2009", "HCC4006", "HCC2279", "H520", "HCC15", 
+                           "H460", "A549", "HCC44", "H1703", "H1299")
+# compile data into list for panSEA input
+Coldren.met.list <- list()
+for (i in 2:ncol(Coldren.met)) {
+  temp.df <- Coldren.met[ , c(1, i)]
+  colnames(temp.df)[2] <- "Input"
+  Coldren.met.list[[all.Coldren.met.names[i-1]]] <- temp.df
+}
+
+##### Step 3: GSE31625 (EGFR inhibitor) #####
+# load series and platform data from GEO
+gset <- getGEO("GSE31625", GSEMatrix =TRUE, AnnotGPL=TRUE)
+if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1
+gset <- gset[[idx]]
+
+# make proper column names to match toptable
+fvarLabels(gset) <- make.names(fvarLabels(gset))
+
+# group membership for all samples
+gsms <- paste0("X11111111XXXXXXXXX0000000XXXXXXXX0000X0000001111") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded
+sml <- strsplit(gsms, split="")[[1]]
+
+# filter out excluded samples (marked as "X")
+sel <- which(sml != "X")
+sml <- sml[sel]
+gset <- gset[ ,sel]
+
+# log2 transformation
+ex <- exprs(gset)
+qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), na.rm=T))
+LogC <- (qx[5] > 100) ||
+  (qx[6]-qx[1] > 50 && qx[2] > 0)
+if (LogC) { ex[which(ex <= 0)] <- NaN
+exprs(gset) <- log2(ex) }
+
+SENS.expr <- as.data.frame(exprs(gset[,which(sml==0)]))
+RES.expr <- as.data.frame(exprs(gset[,which(sml==1)]))
+SENS.GSE31625 <- colnames(SENS.expr)
+# matches with "H1650-8", "H1650-9", "H1650-H", "H1650A", "H1650B", "H1650C",
+# "H1650p8", "H3255_1", "H3255_2", "H3255_3", "H32551-Dec", "PC-9_7", "PC-9_8",
+# "PC-9_9", "PC-9_10", "PC9", "PC92-4val" on GEO
+SENS.GSE31625.names <- c("H1650_1", "H1650_2", "H1650_3", "H1650_4", "H1650_5", 
+                         "H1650_6", "H1650_7", "H3255_1", "H3255_2", "H3255_3", 
+                         "H3255_4", "PC9_1", "PC9_2", "PC9_3", "PC9_4", "PC9_5",
+                         "PC9_6")
+colnames(SENS.expr) <- SENS.GSE31625.names
+
+RES.GSE31625 <- colnames(RES.expr)
+# matches with "A549B", "A549C", "A549-3.05", "A549p2", "A549p3", "A549p4", 
+# "A549p5", "A549p6", "UKY-29_4", "UKY-29_5", "UKY-29_6", "UKY29-3" on GEO
+RES.GSE31625.names <- c("A549_1", "A549_2", "A549-3", "A549_4", "A549_5", 
+                        "A549_6", "A549_7", "A549_8", "UKY29_1", "UKY29_2", 
+                        "UKY29_3", "UKY29_4")
+colnames(RES.expr) <- RES.GSE31625.names
+
+GSE31625.df <- cbind(SENS.expr, RES.expr)
+GSE31625.df$Gene <- rownames(GSE31625.df)
+GSE31625.df <- GSE31625.df[ , c("Gene", 
+                                colnames(GSE31625.df)[
+                                  1:(ncol(GSE31625.df)-1)])]
+
+all.GSE31625.names <- c(SENS.GSE31625.names, RES.GSE31625.names)
+GSE31625.names <- c("H1650", "H3255", "PC9", "A549", "UKY29")
+GSE31625.CCLE_IDs <- c("NCIH1650_LUNG", "NCIH3255_LUNG", "PC9_LUNG", 
+                       "A549_LUNG")
+all.GSE31625.CCLE_IDs <- c()
+for (i in 1:length(all.GSE31625.names)) {
+  if (grepl(GSE31625.names[1], all.GSE31625.names[i])) {
+    all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, GSE31625.CCLE_IDs[1])
+  } else if (grepl(GSE31625.names[2], all.GSE31625.names[i])) {
+    all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, GSE31625.CCLE_IDs[2])
+  } else if (grepl(GSE31625.names[3], all.GSE31625.names[i])) {
+    all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, GSE31625.CCLE_IDs[3])
+  } else if (grepl(GSE31625.names[4], all.GSE31625.names[i])) {
+    all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, GSE31625.CCLE_IDs[4])
+  } else {
+    all.GSE31625.CCLE_IDs <- c(all.GSE31625.CCLE_IDs, NA)
+  }
+}
+
+# compile data into list for panSEA input
+GSE31625 <- list()
+for (i in 2:ncol(GSE31625.df)) {
+  temp.df <- GSE31625.df[ , c(1, i)]
+  colnames(temp.df)[2] <- "Input"
+  GSE31625[[colnames(GSE31625.df)[i]]] <- temp.df
+}
+temp.df <- NULL
+
+##### Step 4: GSE12790 (EGFR inhibitor) #####
+# load series and platform data from GEO
+gset <- getGEO("GSE12790", GSEMatrix =TRUE, AnnotGPL=TRUE)
+if (length(gset) > 1) idx <- grep("GPL570", attr(gset, "names")) else idx <- 1
+gset <- gset[[idx]]
+
+# make proper column names to match toptable
+fvarLabels(gset) <- make.names(fvarLabels(gset))
+
+# group membership for all samples
+gsms <- paste0("XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX1XX",
+               "X0X11X1XX1X1X1XX1XX1X1110X1XX1XXX11X1XX0XX1XXXXX") # 0 is phenotype of numerator in FC; 1 of denominator; X: excluded
+sml <- strsplit(gsms, split="")[[1]]
+
+# filter out excluded samples (marked as "X")
+sel <- which(sml != "X")
+sml <- sml[sel]
+gset <- gset[ ,sel]
+
+# log2 transformation
+ex <- exprs(gset)
+qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), na.rm=T))
+LogC <- (qx[5] > 100) ||
+  (qx[6]-qx[1] > 50 && qx[2] > 0)
+if (LogC) { ex[which(ex <= 0)] <- NaN
+exprs(gset) <- log2(ex) }
+SENS.expr <- as.data.frame(exprs(gset[,which(sml==0)]))
+RES.expr <- as.data.frame(exprs(gset[,which(sml==1)]))
+SENS.GSE12790 <- colnames(SENS.expr)
+# matches with "breast cancer cell line_HCC1806", 
+# "breast cancer cell line_CAL85-1", "breast cancer cell line_HDQ-P1" on GEO
+SENS.GSE12790.names <- c("HCC1806", "CAL851", "HDQ-P1")
+colnames(SENS.expr) <- SENS.GSE12790.names
+
+RES.GSE12790 <- colnames(RES.expr)
+# matches with "breast cancer cell line_BT20", "breast cancer cell line_BT474",
+# "breast cancer cell line_BT483", "breast cancer cell line_CAMA-1",
+# "breast cancer cell line_MCF7", "breast cancer cell line_MDA-MB-231",
+# "breast cancer cell line_MDA-MB-231", "breast cancer cell line_MDA-MB-453",
+# "breast cancer cell line_T47D", "breast cancer cell line_ZR75-1",
+# "breast cancer cell line_CAL-120", "breast cancer cell line_CAL-51", 
+# "breast cancer cell line_EFM-192A", "breast cancer cell line_KPL1", 
+# "breast cancer cell line_HCC1428", "breast cancer cell line_HCC1954", 
+# "breast cancer cell line_HCC1500", "breast cancer cell line_HCC1569" on GEO
+RES.GSE12790.names <- c("BT20", "BT474", "BT483", "CAMA-1", "MCF7", 
+                        "MDAMB231_1", "MDAMB231_2", "MDAMB453", "T47D", 
+                        "ZR751", "CAL120", "CAL51", "EFM192A", "KPL1", 
+                        "HCC1428", "HCC1954", "HCC1500", "HCC1569")
+colnames(RES.expr) <- RES.GSE12790.names
+
+GSE12790.df <- cbind(SENS.expr, RES.expr)
+GSE12790.df$Gene <- rownames(GSE12790.df)
+GSE12790.df <- GSE12790.df[ , c("Gene", 
+                                colnames(GSE12790.df)[
+                                  1:(ncol(GSE12790.df)-1)])]
+
+all.GSE12790.names <- c(SENS.GSE12790.names, RES.GSE12790.names)
+GSE12790.names <- c("HCC1806", "CAL851", "HDQ-P1", "BT20", "BT474", "BT483",
+                    "CAMA1", "MCF7", "MDAMB231", "MDAMB453", "T47D", 
+                    "ZR751", "CAL120", "CAL51", "EFM192A", "KPL1",
+                    "HCC1428", "HCC1954", "HCC1500", "HCC1569")
+GSE12790.CCLE_IDs <- c("HCC1806_BREAST", "CAL851_BREAST", "HDQP1_BREAST", 
+                       "BT20_BREAST", "BT474_BREAST", "BT483_BREAST", 
+                       "CAMA1_BREAST", "MCF7_BREAST", "MDAMB231_BREAST",
+                       "MDAMB453_BREAST", "T47D_BREAST", "ZR751_BREAST",
+                       "CAL120_BREAST", "CAL51_BREAST", "EFM192A_BREAST",
+                       "KPL1_BREAST", "HCC1428_BREAST", "HCC1954_BREAST",
+                       "HCC1500_BREAST", "HCC1569_BREAST")
+all.GSE12790.CCLE_IDs <- c()
+for (i in 1:length(all.GSE12790.names)) {
+  match <- FALSE
+  for (j in 1:length(GSE12790.names)) {
+    if (grepl(GSE12790.names[j], all.GSE12790.names[i])) {
+      all.GSE12790.CCLE_IDs <- c(all.GSE12790.CCLE_IDs, GSE12790.CCLE_IDs[j])
+      match <- TRUE
+      break
+    }
+  }
+  if (!match) {
+    all.GSE12790.CCLE_IDs <- c(all.GSE12790.CCLE_IDs, NA)
+  }
+}
+
+# compile data into list for panSEA input
+GSE12790 <- list()
+for (i in 2:ncol(GSE12790.df)) {
+  temp.df <- GSE12790.df[ , c(1, i)]
+  colnames(temp.df)[2] <- "Input"
+  GSE12790[[colnames(GSE12790.df)[i]]] <- temp.df
+}
+temp.df <- NULL
+
+##### Step 5: run panSEA #####
+dir.create("cell_corr")
+setwd("cell_corr")
+# IMPORTANT: each group must have the same # & position of samples across data sets
+# e.g. "Sensitive" samples must be in the same columns across input data.list
+# but "Resistant" could have different # as "Sensitive" hypothetically
+group.names <- "Sensitive or Resistant"
+group.samples <- 2
+
+# get gene set info
+msigdb.info <- msigdbr::msigdbr("Homo sapiens", "C2", "CP:KEGG")
+
+# extract necessary info into data frame
+msigdb.info <- as.data.frame(msigdb.info[, c(
+  "gene_symbol",
+  "gs_name",
+  "gs_description"
+)])
+
+gene.gmt <- DMEA::as_gmt(
+  msigdb.info, "gene_symbol", "gs_name", min.per.set = 6,
+  descriptions = "gs_description")
+saveRDS(gene.gmt, "gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds")
+gene.gmt <- readRDS("Inputs/gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds")
+gene.gmt <- readRDS("gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds")
+
+# get metabolite set info
+# based on hmdb v5.0 downloaded 20231220: https://hmdb.ca/downloads 
+hmdb <- XML::xmlToDataFrame("hmdb_metabolites.xml")
+saveRDS(hmdb, "hmdb_metabolites_dataframe.rds")
+hmdb <- readRDS("hmdb_metabolites_dataframe.rds")
+#hmdb$class <- sub(".*belongs to the class of organic compounds known as (.+)\\..*", "\\1", hmdb$taxonomy)
+hmdb$class <- NA
+hmdb$class <- stringr::str_match(hmdb$taxonomy, "belongs to the class of organic compounds known as\\s*(.*?)\\s*\\. ")[ , 2]
+#inorganic.hmdb <- hmdb[is.na(hmdb$class), ] # 72291 / 217920
+hmdb[is.na(hmdb$class), ]$class <- 
+  stringr::str_match(
+    hmdb[is.na(hmdb$class), ]$taxonomy, 
+    "belongs to the class of inorganic compounds known as\\s*(.*?)\\s*\\. ")[ , 2]
+#unclassified.hmdb <- hmdb[is.na(hmdb$class), ] # 71984 / 217920
+#nonblank.unclassified.hmdb <- unclassified.hmdb[unclassified.hmdb$taxonomy != "\n  ", ] # 1 / 71984
+hmdb[is.na(hmdb$class), ]$class <- 
+  stringr::str_match(
+    hmdb[is.na(hmdb$class), ]$taxonomy, 
+    "belongs to the class of chemical entities known as\\s*(.*?)\\s*\\. ")[ , 2]
+#unclassified.hmdb <- hmdb[is.na(hmdb$class), ] # 71983 / 217920
+saveRDS(hmdb, "hmdb_metabolites_dataframe_with_class.rds")
+hmdb <- readRDS("hmdb_metabolites_dataframe_with_class.rds")
+hmdb <- dplyr::distinct(na.omit(hmdb[ , c("name", "class")])) # 145937 metabolites
+
+met.gmt <- DMEA::as_gmt(hmdb, "name", "class", min.per.set = 6)
+saveRDS(met.gmt, "gmt_HMDB.rds")
+
+hmdb <- readRDS("hmdb_metabolites_dataframe_with_class.rds")
+hmdb <- dplyr::distinct(na.omit(hmdb[ , c("name", "class")])) # 145937 metabolites
+# hmdb.wide <- reshape2::dcast(hmdb, class ~ name)
+# hmdb.match <- colnames(hmdb.wide)[tolower(colnames(hmdb.wide)) %in% colnames(met.df)[2:ncol(met.df)]] # 46 / 225
+hmdb.CCLE <- hmdb[tolower(hmdb$name) %in% colnames(met.df)[2:ncol(met.df)], ] # 46 / 225
+hmdb.CCLE$name <- lapply(hmdb.CCLE$name, tolower)
+met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 6)
+saveRDS(met.gmt, "gmt_HMDB_in_CCLE.rds")
+hmdb <- NULL
+met.gmt <- readRDS("gmt_HMDB_in_CCLE.rds")
+
+# increase # of groups with 6+ metabolites
+hmdb.CCLE[grep("alpha", hmdb.CCLE$class), ]$class <- "alpha amino acids"
+met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 6)
+saveRDS(met.gmt, "gmt_HMDB_in_CCLE_2sets.rds")
+met.gmt <- readRDS("Inputs/gmt_HMDB_in_CCLE_2sets.rds")
+met.gmt <- readRDS("gmt_HMDB_in_CCLE_2sets.rds")
+
+# met.gmt <- DMEA::as_gmt(hmdb.CCLE, "name", "class", min.per.set = 4)
+# saveRDS(met.gmt, "gmt_HMDB_in_CCLE_4minperset.rds")
+
+#### Step 5a: GSE12790 ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.GSE12790.names)) {
+  gmt.features[[all.GSE12790.names[i]]] <- gene.gmt
+  expression[[all.GSE12790.names[i]]] <- RNA.df[
+    RNA.df$CCLE_ID != all.GSE12790.CCLE_IDs[i], ]
+}
+
+Fig2.panSEA <- panSEA::panSEA(GSE12790, all.GSE12790.names, GSEA = FALSE,
+                              GSEA.rank.var = rep("Input", length(GSE12790)),
+                              DMEA.type = "cell_corr", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              #gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+
+# Loading PRISM drug sensitivity AUC scores
+# Loading PRISM drug mechanism of action annotations
+# Read 85 records
+# Read 3655 items
+# 123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384851
+# 2
+# 3
+# 4
+# 5
+# 6
+# 7
+# 8
+# 9
+# 10
+# 11
+# 12
+# 13
+# 14
+# 15
+# 16
+# 17
+# 18
+# 19
+# 20
+# 21
+# 22
+# 23
+# 24
+# 25
+# 26
+# 27
+# 28
+# 29
+# 30
+# 31
+# 32
+# 33
+# 34
+# 35
+# 36
+# 37
+# 38
+# 39
+# 40
+# 41
+# 42
+# 43
+# 44
+# 45
+# 46
+# 47
+# 48
+# 49
+# 50
+# 51
+# 52
+# 53
+# 54
+# 55
+# 56
+# 57
+# 58
+# 59
+# 60
+# 61
+# 62
+# 63
+# 64
+# 65
+# 66
+# 67
+# 68
+# 69
+# 70
+# 71
+# 72
+# 73
+# 74
+# 75
+# 76
+# 77
+# 78
+# 79
+# 80
+# 81
+# 82
+# 83
+# 84
+# Running DMEA using HCC1806 data
+# Running correlations and regressions...
+# Error in `[.data.frame`(all.data.corr, , 3:ncol(all.data.corr)) : 
+#   undefined columns selected
+
+# save results
+fig.folder <- "Fig2"
+savePanSEA(Fig2.panSEA, fig.folder)
+#Fig2.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+Fig2.panSEA <- NULL # make space to process next analysis
+
+#### Step 5b: GSE31625 ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.GSE31625.names)) {
+  gmt.features[[all.GSE31625.names[i]]] <- gene.gmt
+  expression[[all.GSE31625.names[i]]] <- RNA.df[
+    RNA.df$CCLE_ID != all.GSE31625.CCLE_IDs[i], ]
+}
+
+Fig3.panSEA <- panSEA::panSEA(GSE31625, all.GSE31625.names, GSEA = FALSE,
+                              GSEA.rank.var = rep("Input", length(GSE31625)),
+                              DMEA.type = "cell_corr", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+# not doing GSEA because not enough sets for H1650_1 sample
+# again DMEA issue with H1650_1:
+# Running DMEA using H1650_1 data
+# Running correlations and regressions...
+# Error in `[.data.frame`(all.data.corr, , 3:ncol(all.data.corr)) : 
+#   undefined columns selected
+
+# try removing H1650_1
+GSE31625v2 <- GSE31625[2:length(GSE31625)]
+all.GSE31625.namesv2 <- all.GSE31625.names[2:length(all.GSE31625.names)]
+gmt.featuresv2 <- gmt.features[2:length(gmt.features)]
+expressionv2 <- expression[2:length(expression)]
+
+Fig3.panSEA <- panSEA::panSEA(GSE31625v2, all.GSE31625.namesv2, GSEA = FALSE,
+                              GSEA.rank.var = rep("Input", length(GSE31625v2)),
+                              DMEA.type = "cell_corr", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.featuresv2,
+                              expression = expressionv2,
+                              scatter.plots = FALSE)
+
+# realized it was because gene ids are not gene symbols
+# save results
+fig.folder <- "Fig3_GSE31625"
+setwd(base.path)
+setwd("cell_corr")
+savePanSEA(Fig3.panSEA, fig.folder, GSEA = FALSE)
+#Fig3.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+Fig3.panSEA <- NULL # make space to process next analysis
+
+#### Step 5c: Coldren ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.names)) {
+  gmt.features[[all.Coldren.names[i]]] <- gene.gmt
+  expression[[all.Coldren.names[i]]] <- RNA.df[
+    RNA.df$CCLE_ID != all.Coldren.CCLE_IDs[i], ]
+}
+
+Fig4.panSEA <- panSEA::panSEA(Coldren, all.Coldren.names, 
+                              GSEA.rank.var = rep("Input", length(Coldren)),
+                              DMEA.type = "cell_corr", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression)
+# save results
+fig.folder <- "Fig4"
+savePanSEA(Fig4.panSEA, fig.folder)
+#Fig4.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+Fig4.panSEA <- NULL # make space to process next analysis
+
+#### Step 5d: Coldren proteomics ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.prot.names)) {
+  gmt.features[[all.Coldren.prot.names[i]]] <- gene.gmt
+  expression[[all.Coldren.prot.names[i]]] <- prot.df[
+    prot.df$CCLE_ID != all.Coldren.prot.CCLE_IDs[i], ]
+}
+
+Fig5.panSEA <- panSEA::panSEA(Coldren.prot.list, all.Coldren.prot.names, 
+                              GSEA.rank.var = rep("Input", 
+                                                  length(Coldren.prot.list)),
+                              DMEA.type = "cell_corr", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression)
+# save results
+fig.folder <- "Fig5"
+setwd(base.path)
+setwd("cell_corr")
+savePanSEA(Fig5.panSEA, fig.folder)
+#Fig5.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+Fig5.panSEA <- NULL # make space to process next analysis
+
+#### Step 5e: Coldren metabolomics ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.met.names)) {
+  gmt.features[[all.Coldren.met.names[i]]] <- met.gmt
+  expression[[all.Coldren.met.names[i]]] <- met.df[
+    met.df$CCLE_ID != all.Coldren.met.CCLE_IDs[i], ]
+}
+
+Fig6.panSEA <- panSEA::panSEA(Coldren.met.list, all.Coldren.met.names, 
+                              feature.names = rep("Metabolite", length(Coldren.met.list)),
+                              GSEA.rank.var = rep("Input", 
+                                                  length(Coldren.met.list)),
+                              DMEA.type = "cell_corr", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+# save results
+fig.folder <- "Fig6"
+setwd(base.path)
+setwd("cell_corr")
+savePanSEA(Fig6.panSEA, fig.folder)
+#Fig6.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+Fig6.panSEA <- NULL # make space to process next analysis
+
+#### Step 5f: Coldren but only querying non-small-cell lung cancer cell line data ####
+NSCLC.samples <- cell.line.info[cell.line.info$lineage_subtype == "NSCLC", ] # 273 CCLE
+NSCLC.RNA.df <- RNA.df[RNA.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 63 CCLE
+NSCLC.prot.df <- prot.df[prot.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 78 CCLE
+NSCLC.met.df <- met.df[met.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 182 CCLE
+NSCLC.prot.df.noNA <- NSCLC.prot.df[, colSums(is.na(NSCLC.prot.df)) == 0] # 5565 gene names
+
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.names)) {
+  gmt.features[[all.Coldren.names[i]]] <- gene.gmt
+  expression[[all.Coldren.names[i]]] <- NSCLC.RNA.df[
+    NSCLC.RNA.df$CCLE_ID != all.Coldren.CCLE_IDs[i], ]
+}
+
+Fig7.panSEA <- panSEA::panSEA(Coldren, all.Coldren.names, 
+                              GSEA.rank.var = rep("Input", length(Coldren)),
+                              DMEA.type = "cell_corr", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+
+# save results
+setwd(base.path)
+setwd("cell_corr")
+savePanSEA(Fig7.panSEA, "Fig7_Coldren_transcr_NSCLC")
+Fig7.panSEA <- NULL # make space to process next analysis
+
+#### Step 5g: Coldren proteomics but only querying non-small-cell lung cancer cell line data ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.prot.names)) {
+  gmt.features[[all.Coldren.prot.names[i]]] <- gene.gmt
+  expression[[all.Coldren.prot.names[i]]] <- NSCLC.prot.df.noNA[
+    NSCLC.prot.df.noNA$CCLE_ID != all.Coldren.prot.CCLE_IDs[i], ]
+}
+
+Fig8.panSEA <- panSEA::panSEA(Coldren.prot.list, all.Coldren.prot.names, 
+                              GSEA.rank.var = rep("Input", 
+                                                  length(Coldren.prot.list)),
+                              DMEA.type = "cell_corr", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+
+# save results
+setwd(base.path)
+setwd("cell_corr")
+savePanSEA(Fig8.panSEA, "Fig8_Coldren_prot_NSCLC")
+Fig8.panSEA <- NULL # make space to process next analysis
+
+#### Step 5h: Coldren metabolomics but only querying non-small-cell lung cancer cell line data ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.met.names)) {
+  gmt.features[[all.Coldren.met.names[i]]] <- met.gmt
+  expression[[all.Coldren.met.names[i]]] <- NSCLC.met.df[
+    NSCLC.met.df$CCLE_ID != all.Coldren.met.CCLE_IDs[i], ]
+}
+
+Fig9.panSEA <- panSEA::panSEA(Coldren.met.list, all.Coldren.met.names, 
+                              feature.names = rep("Metabolite", length(Coldren.met.list)),
+                              GSEA.rank.var = rep("Input", 
+                                                  length(Coldren.met.list)),
+                              DMEA.type = "cell_corr", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+
+# save results
+setwd(base.path)
+setwd("cell_corr")
+savePanSEA(Fig9.panSEA, "Fig9_Coldren_met_NSCLC")
+Fig9.panSEA <- NULL # make space to process next analysis
+
+##### Step 6: run panSEA with WV #####
+setwd(base.path)
+dir.create("ssDMEA_WV")
+setwd("ssDMEA_WV")
+# IMPORTANT: each group must have the same # & position of samples across data sets
+# e.g. "Sensitive" samples must be in the same columns across input data.list
+# but "Resistant" could have different # as "Sensitive" hypothetically
+group.names <- "Sensitive or Resistant"
+group.samples <- 2
+
+# get gene set info
+gene.gmt <- readRDS("gmt_MSigDB_Homo-sapiens_C2_CP:KEGG.rds")
+
+# get metabolite set info
+met.gmt <- readRDS("gmt_HMDB_in_CCLE_2sets.rds")
+
+#### Step 6a: GSE12790 ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.GSE12790.names)) {
+  gmt.features[[all.GSE12790.names[i]]] <- gene.gmt
+  expression[[all.GSE12790.names[i]]] <- RNA.df[
+    RNA.df$CCLE_ID != all.GSE12790.CCLE_IDs[i], ]
+}
+
+GSE12790.panSEA <- panSEA::panSEA(GSE12790, all.GSE12790.names, GSEA = FALSE,
+                              GSEA.rank.var = rep("Input", length(GSE12790)),
+                              GSEA = FALSE, DMEA.type = "WV", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              #gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+
+# save results
+fig.folder <- "GSE12790"
+savePanSEA(GSE12790.panSEA, fig.folder)
+#GSE12790.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+GSE12790.panSEA <- NULL # make space to process next analysis
+
+#### Step 6b: GSE31625 ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.GSE31625.names)) {
+  gmt.features[[all.GSE31625.names[i]]] <- gene.gmt
+  expression[[all.GSE31625.names[i]]] <- RNA.df[
+    RNA.df$CCLE_ID != all.GSE31625.CCLE_IDs[i], ]
+}
+
+GSE31625.panSEA <- panSEA::panSEA(GSE31625, all.GSE31625.names, 
+                              GSEA.rank.var = rep("Input", length(GSE31625)),
+                              GSEA = FALSE, DMEA.type = "WV", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+# save results
+fig.folder <- "GSE31625"
+savePanSEA(GSE31625.panSEA, fig.folder)
+#GSE31625.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+GSE31625.panSEA <- NULL # make space to process next analysis
+
+#### Step 6c: Coldren ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.names)) {
+  gmt.features[[all.Coldren.names[i]]] <- gene.gmt
+  expression[[all.Coldren.names[i]]] <- RNA.df[
+    RNA.df$CCLE_ID != all.Coldren.CCLE_IDs[i], ]
+}
+
+Coldren.panSEA <- panSEA::panSEA(Coldren, all.Coldren.names, 
+                              GSEA.rank.var = rep("Input", length(Coldren)),
+                              GSEA = FALSE, DMEA.type = "WV", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+# save results
+fig.folder <- "Coldren"
+savePanSEA(Coldren.panSEA, fig.folder, GSEA = FALSE)
+#Coldren.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+Coldren.panSEA <- NULL # make space to process next analysis
+
+#### Step 6d: Coldren proteomics ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.prot.names)) {
+  gmt.features[[all.Coldren.prot.names[i]]] <- gene.gmt
+  expression[[all.Coldren.prot.names[i]]] <- prot.df[
+    prot.df$CCLE_ID != all.Coldren.prot.CCLE_IDs[i], ]
+}
+
+Coldren.prot.panSEA <- panSEA::panSEA(Coldren.prot.list, all.Coldren.prot.names, 
+                              GSEA.rank.var = rep("Input", 
+                                                  length(Coldren.prot.list)),
+                              GSEA = FALSE, DMEA.type = "WV", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression, scatter.plots = FALSE)
+# save results
+fig.folder <- "Coldren.prot"
+setwd(base.path)
+setwd("ssDMEA_WV")
+savePanSEA(Coldren.prot.panSEA, fig.folder, GSEA = FALSE)
+#Coldren.prot.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+Coldren.prot.panSEA <- NULL # make space to process next analysis
+
+#### Step 6e: Coldren metabolomics ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.met.names)) {
+  gmt.features[[all.Coldren.met.names[i]]] <- met.gmt
+  expression[[all.Coldren.met.names[i]]] <- met.df[
+    met.df$CCLE_ID != all.Coldren.met.CCLE_IDs[i], ]
+}
+
+Coldren.met.panSEA <- panSEA::panSEA(Coldren.met.list, all.Coldren.met.names, 
+                                     feature.names = rep("Metabolite", length(Coldren.met.list)),
+                              GSEA.rank.var = rep("Input", 
+                                                  length(Coldren.met.list)),
+                              GSEA = FALSE, DMEA.type = "WV", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+# save results
+fig.folder <- "Coldren.met"
+setwd(base.path)
+setwd("ssDMEA_WV")
+savePanSEA(Coldren.met.panSEA, fig.folder, GSEA = FALSE)
+#Coldren.met.panSEA <- readRDS(paste0("panSEA_", fig.folder, ".rds"))
+Coldren.met.panSEA <- NULL # make space to process next analysis
+
+#### Step 6f: Coldren but only querying non-small-cell lung cancer cell line data ####
+NSCLC.samples <- cell.line.info[cell.line.info$lineage_subtype == "NSCLC", ] # 273 CCLE
+NSCLC.RNA.df <- RNA.df[RNA.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 63 CCLE
+NSCLC.prot.df <- prot.df[prot.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 78 CCLE
+NSCLC.met.df <- met.df[met.df$CCLE_ID %in% NSCLC.samples$CCLE_Name, ] # 182 CCLE
+NSCLC.prot.df.noNA <- NSCLC.prot.df[, colSums(is.na(NSCLC.prot.df)) == 0] # 5565 gene names
+
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.names)) {
+  gmt.features[[all.Coldren.names[i]]] <- gene.gmt
+  expression[[all.Coldren.names[i]]] <- NSCLC.RNA.df[
+    NSCLC.RNA.df$CCLE_ID != all.Coldren.CCLE_IDs[i], ]
+}
+
+Coldren.NSCLC.panSEA <- panSEA::panSEA(Coldren, all.Coldren.names, 
+                              GSEA.rank.var = rep("Input", length(Coldren)),
+                              GSEA = FALSE, DMEA.type = "WV", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+
+# save results
+setwd(base.path)
+setwd("ssDMEA_WV")
+savePanSEA(Coldren.NSCLC.panSEA, "Coldren_trascr_NSCLC", GSEA = FALSE)
+Coldren.NSCLC.panSEA <- NULL # make space to process next analysis
+
+#### Step 6g: Coldren proteomics but only querying non-small-cell lung cancer cell line data ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.prot.names)) {
+  gmt.features[[all.Coldren.prot.names[i]]] <- gene.gmt
+  expression[[all.Coldren.prot.names[i]]] <- NSCLC.prot.df.noNA[
+    NSCLC.prot.df.noNA$CCLE_ID != all.Coldren.prot.CCLE_IDs[i], ]
+}
+
+Coldren.NSCLC.prot.panSEA <- panSEA::panSEA(Coldren.prot.list, all.Coldren.prot.names, 
+                              GSEA.rank.var = rep("Input", 
+                                                  length(Coldren.prot.list)),
+                              GSEA = FALSE, DMEA.type = "WV", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+
+# save results
+setwd(base.path)
+setwd("ssDMEA_WV")
+savePanSEA(Coldren.NSCLC.prot.panSEA, "Coldren_prot_NSCLC", GSEA = FALSE)
+Coldren.NSCLC.prot.panSEA <- NULL # make space to process next analysis
+
+#### Step 6h: Coldren metabolomics but only querying non-small-cell lung cancer cell line data ####
+gmt.features <- list()
+expression <- list()
+for (i in 1:length(all.Coldren.met.names)) {
+  gmt.features[[all.Coldren.met.names[i]]] <- met.gmt
+  expression[[all.Coldren.met.names[i]]] <- NSCLC.met.df[
+    NSCLC.met.df$CCLE_ID != all.Coldren.met.CCLE_IDs[i], ]
+}
+
+Coldren.NSCLC.met.panSEA <- panSEA::panSEA(Coldren.met.list, all.Coldren.met.names, 
+                                           feature.names = rep("Metabolite", length(Coldren.met.list)),
+                              GSEA.rank.var = rep("Input", 
+                                                  length(Coldren.met.list)),
+                              GSEA = FALSE, DMEA.type = "WV", 
+                              group.names = group.names,
+                              group.samples = group.samples, 
+                              gmt.features = gmt.features,
+                              expression = expression,
+                              scatter.plots = FALSE)
+
+# save results
+setwd(base.path)
+setwd("ssDMEA_WV")
+savePanSEA(Coldren.NSCLC.met.panSEA, "Coldren_met_NSCLC", GSEA = FALSE)
+Coldren.NSCLC.met.panSEA <- NULL # make space to process next analysis
+
diff --git a/Examples/ssDMEA_WV/.DS_Store b/Examples/ssDMEA_WV/.DS_Store
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diff --git a/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_correlation_matrix.pdf b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_correlation_matrix.pdf
new file mode 100644
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diff --git a/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_dot_plot.pdf b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_dot_plot.pdf
new file mode 100644
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diff --git a/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_interactive_network.graph.html b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
index 0000000..60f6cca
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
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+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
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+      };
+
+    } else {
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+      el.style.height = px(sizing.height);
+
+      return {
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+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
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diff --git a/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..1dffa5b
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_mean_results.csv
@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"MEK inhibitor",1.837,0.0718258126889007,1.04805803593986e-14,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"A549",4.34944084915044e-13
+"AP inhibitor",1.658,0.161264738208555,3.3671360440357e-10,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"CALU3",6.98680729137407e-09
+"HSP inhibitor",1.4845,0.162204386987204,7.84433373523757e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",5.91890636386107e-06
+"CHK inhibitor",1.459,0.124515904712273,2.49244058868342e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.47766120614803e-05
+"bacterial DNA gyrase inhibitor",1.398,0.113721728701895,5.93068477388403e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000307654272645234
+"estrogen receptor agonist",1.2995,0.0888212279036706,0.00199808555192968,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00753823185500743
+"thymidylate synthase inhibitor",1.2256,0.188098070725157,0.0130029033245659,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0415092683053451
+"glucocorticoid receptor agonist",1.2007,0.187024653595807,0.0260713767854997,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0769886029780495
+"adrenergic receptor antagonist",1.1705,0.0814652008367279,0.0570644407717307,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.143525714668292
+"proteasome inhibitor",1.1327,0.157606471948331,0.10491171311871,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.248790633967226
+"EGFR inhibitor",1.1262,0.148325602006283,0.127977156233972,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.295058443539436
+"ATPase inhibitor",0.83905,0.115644862447609,0.998061654194559,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"phosphodiesterase inhibitor",0.76505,0.17273846217849,0.999923243164951,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"DNA polymerase inhibitor",0.6789,0.482692110650475,0.999173327925464,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"cytochrome P450 inhibitor",0.62805,0.646229426018834,0.970017345337301,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"tubulin polymerization inhibitor",0.60165,0.537214675799849,0.998994665050148,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"benzodiazepine receptor agonist",0.54955,0.369565958075715,0.999999999956194,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"potassium channel blocker",0.53295,0.618733041234901,0.999579694939796,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"glutamate receptor antagonist",0.466,0.660526902914396,0.999874413399112,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"HCV inhibitor",0.4564,0.679967135428734,0.999807482677365,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"protein synthesis inhibitor",0.4486,0.793560225552508,0.983668059741666,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"src inhibitor",0.3754,0.945900150511058,0.752690881653816,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"RAF inhibitor",0.0822999999999999,0.801939694543306,0.99996382852263,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"PLK inhibitor",-0.01665,0.827688682575253,0.999779321057991,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"DNA methyltransferase inhibitor",-0.03195,0.985599922836207,0.907422784600226,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"microtubule inhibitor",-0.0979,0.591130308904275,0.999999999999991,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"tyrosine kinase inhibitor",-0.33585,0.527821368806172,0.999999999999913,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"RET tyrosine kinase inhibitor",-0.4127,0.78838756832838,0.9972876450892,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"TGF beta receptor inhibitor",-0.4863,0.790787821698949,0.985255632193486,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"ALK tyrosine kinase receptor inhibitor",-0.5731,0.43039833447144,0.999999989123903,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"topoisomerase inhibitor",-0.6991,0.340221584141555,0.999980915607873,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"protein tyrosine kinase inhibitor",-0.70065,0.376475941077948,0.999974859367147,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"NFkB pathway inhibitor",-0.7625,0.162951881822438,0.9999821647786,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"histamine receptor antagonist",-0.76335,0.114108108941984,0.999994692911645,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"cyclooxygenase inhibitor",-0.7705,0.0433620013133012,0.999997319224395,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"ribonucleotide reductase inhibitor",-0.78155,0.0886011019297045,0.999986589116802,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"VEGFR inhibitor",-0.807,0.0794043615400247,0.99995711607612,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"DNA synthesis inhibitor",-0.8334,0.0772394772257378,0.999711085773,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"progesterone receptor agonist",-0.85815,0.0710820689507262,0.999110209679851,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"JAK inhibitor",-0.8592,0.0840711478138418,0.998951201956296,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"PPAR receptor agonist",-0.8788,0.0778166536092845,0.996498089611052,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"DNA alkylating agent",-0.90985,0.0758032598937956,0.988467027005913,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"HMGCR inhibitor",-0.92915,0.515218019769046,0.351644249465577,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.694916016801021
+"PI3K inhibitor",-0.94995,0.0644780460393507,0.952406632479659,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"DNA inhibitor",-0.9703,0.0807172452714445,0.919173511629033,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"dopamine receptor antagonist",-0.9774,0.0688380249877241,0.907873250445604,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"CDK inhibitor",-0.99695,0.228528352496439,0.665560924904876,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"opioid receptor agonist",-1.01205,0.175418439587657,0.713462791798366,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"mTOR inhibitor",-1.0258,0.0899746163034184,0.733392721944979,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"adrenergic receptor agonist",-1.0335,0.109414951350112,0.694733318769849,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"sodium channel blocker",-1.0539,0.0615013050781509,0.599552023234603,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999991
+"acetylcholine receptor agonist",-1.0721,0.0859509652130366,0.529611475537834,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.99903982885546
+"CC chemokine receptor antagonist",-1.079,0.186614717081957,0.363867647047123,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.702349179183981
+"KIT inhibitor",-1.10615,0.0745980633303008,0.336461213113685,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.681128797278922
+"BCL inhibitor",-1.11665,0.170836725683049,0.190451749940676,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.400633051217512
+"phosphatase inhibitor",-1.1286,0.0917957687363352,0.193076169261452,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.400633051217512
+"AKT inhibitor",-1.13275,0.170969949652594,0.139538304499633,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.313018358742419
+"p38 MAPK inhibitor",-1.14975,0.0867154299388159,0.143409429021606,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.313236384441929
+"PDGFR tyrosine kinase receptor inhibitor",-1.1715,0.0640127454414147,0.0938326096386162,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.229061958823681
+"MDM inhibitor",-1.19205,0.19130946959807,0.0278272058956806,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0769886029780495
+"antioxidant",-1.19555,0.0894677095528414,0.0541876529562529,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.140549224855281
+"acetylcholine receptor antagonist",-1.2049,0.139171193329049,0.0312283163105961,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0836112985090153
+"growth factor receptor inhibitor",-1.2165,0.0873754753017718,0.0233061897848472,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0716449537830488
+"serotonin receptor antagonist",-1.2215,0.077342369405541,0.0271127185821637,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0769886029780495
+"Bcr.Abl kinase inhibitor",-1.2475,0.122297092963686,0.0101361296128085,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0336519503145243
+"HDAC inhibitor",-1.263,0.121573023323433,0.004788238329597,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0165593242231896
+"Abl kinase inhibitor",-1.267,0.107120198105237,0.00406328611433477,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0146631629343385
+"adenosine receptor antagonist",-1.2915,0.115041182557424,0.00131193028439299,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00544451068023093
+"glycogen synthase kinase inhibitor",-1.2925,0.0789986675437264,0.00185730876296803,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00734079177744505
+"retinoid receptor agonist",-1.3245,0.169441031506229,0.000182196746427658,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000840129441860868
+"vitamin D receptor agonist",-1.328,0.102320446071206,0.000329944258200849,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.0014413354437195
+"bacterial 50S ribosomal subunit inhibitor",-1.339,0.0994670006108876,0.000152020199449106,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000742216267898577
+"calcium channel blocker",-1.4,0.144913767461894,3.35624847546601e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.85712415642453e-05
+"androgen receptor antagonist",-1.41,0.15556349186104,2.3420775476773e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.47766120614803e-05
+"serotonin receptor agonist",-1.4245,0.0628678647724943,2.26521432280365e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.47766120614803e-05
+"sterol demethylase inhibitor",-1.4375,0.129487857589652,2.96178476951966e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",2.45828135870132e-06
+"Aurora kinase inhibitor",-1.4515,0.106290317428011,2.18601397223425e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",2.0159906632827e-06
+"FLT3 inhibitor",-1.457,0.0606196077363196,1.80806381591151e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.87586620900819e-06
+"FGFR inhibitor",-1.4725,0.117198661749141,4.13354078350316e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",4.90119835758232e-07
+"PARP inhibitor",-1.479,0.0689698637468798,2.09328525795183e-08,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",2.89571127350003e-07
+"bromodomain inhibitor",-1.49355,0.313164573347625,9.21872485605836e-10,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,4,"H358, H520, H460, H1299",1.53030832610569e-08
+"MET inhibitor",-1.5835,0.145973141004559,6.72990294094476e-11,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC95",1.86193981366138e-09
+"estrogen receptor antagonist",-1.7155,0.100758961988761,1.41776750072524e-17,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"H3255, HCC15",1.17674702560195e-15
diff --git a/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..2a8e021
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_results.csv
@@ -0,0 +1,1661 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H358","Pearson.est","EGFR inhibitor",0.32984,0.937,0.516,70,0.754,"pelitinib, vandetanib, canertinib, brigatinib, erlotinib, XL.647, BMS.690514, rociletinib, afatinib",0.287350298372789,0.122628654130226,FALSE
+"H358","Pearson.est","Abl kinase inhibitor",-0.47766,-1.15,0.28,1109,0.68,"flumatinib, nilotinib, KW.2449, ponatinib, imatinib, tozasertib",0.552841968657781,0.167491087293764,FALSE
+"H358","Pearson.est","acetylcholine receptor agonist",-0.40273,-0.966,0.524,945,0.814,"xanomeline, nicotine, nefiracetam, pilocarpine",0.280668713016273,0.0893755951107988,FALSE
+"H358","Pearson.est","acetylcholine receptor antagonist",-0.51404,-1.25,0.197,830,0.527,"diphemanil, dicycloverine, iododexetimide, methscopolamine",0.705533773838407,0.278189384787453,FALSE
+"H358","Pearson.est","adenosine receptor antagonist",-0.60691,-1.49,0.0556,1227,0.48,"MRS.1220, CGS.15943, SCH.58261",1.25492520841794,0.318758762624413,FALSE
+"H358","Pearson.est","adrenergic receptor agonist",-0.40384,-0.969,0.506,1137,0.829,"clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.295849483160201,0.0814454694497265,FALSE
+"H358","Pearson.est","adrenergic receptor antagonist",0.38547,1.13,0.273,218,0.763,"prazosin, vincamine, RS.17053, practolol, imiloxan, atenolol...., levobunolol, idazoxan",0.563837352959244,0.11747546204512,FALSE
+"H358","Pearson.est","AKT inhibitor",-0.60187,-1.44,0.071,1106,0.463,"GDC.0068, triciribine, ONC201, CCT128930, uprosertib, A.674563",1.14874165128092,0.334419008982047,FALSE
+"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24096,-0.583,0.944,1163,0.951,"AP26113, alectinib, DMH1",0.025028005701931,0.0218194830625861,FALSE
+"H358","Pearson.est","androgen receptor antagonist",-0.61522,-1.5,0.0616,995,0.517,"nilutamide, flutamide, bicalutamide",1.21041928783557,0.286509456906058,FALSE
+"H358","Pearson.est","antioxidant",-0.45293,-1.12,0.329,1274,0.725,"benfotiamine, trolox",0.482804102050026,0.139661993429006,FALSE
+"H358","Pearson.est","AP inhibitor",0.62938,1.81,0.0258,25,0.54,"GDC.0152, birinapant",1.58838029403677,0.267606240177031,FALSE
+"H358","Pearson.est","ATPase inhibitor",0.31855,0.903,0.557,124,0.721,"k.strophanthidin, digitoxin, ouabain",0.254144804826271,0.142064735280571,FALSE
+"H358","Pearson.est","Aurora kinase inhibitor",-0.63562,-1.52,0.0553,1131,0.543,"CCT137690, CCT129202, KW.2449, ENMD.2076, barasertib.HQPA, AMG900, aurora.a.inhibitor.i, MK.8745, PF.03814735, SNS.314, AT.9283, barasertib, hesperadin, tozasertib",1.2572748686953,0.265200170411153,FALSE
+"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.55922,-1.33,0.14,822,0.496,"azithromycin, valnemulin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.853871964321762,0.304518323509803,FALSE
+"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.53677,1.55,0.0702,207,0.492,"finafloxacin, sarafloxacin, novobiocin, sparfloxacin",1.15366288787019,0.30803489723264,FALSE
+"H358","Pearson.est","BCL inhibitor",-0.5451,-1.32,0.157,1217,0.465,"gossypol, ABT.737",0.804100347590766,0.332547047110046,FALSE
+"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.44341,-1.05,0.405,1109,0.789,"flumatinib, nilotinib, ponatinib, imatinib, tozasertib",0.392544976785331,0.10292299679058,FALSE
+"H358","Pearson.est","benzodiazepine receptor agonist",0.22955,0.67,0.887,134,0.908,"gamma.aminobutyric.acid, ZK.93423, eprinomectin",0.0520763801682736,0.0419141514789149,FALSE
+"H358","Pearson.est","bromodomain inhibitor",-0.80675,-1.94,0.00254,1192,0.0685,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.59516628338006,1.16430942850757,TRUE
+"H358","Pearson.est","calcium channel blocker",-0.64665,-1.57,0.0426,1239,0.594,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.37059040089728,0.226213555018806,FALSE
+"H358","Pearson.est","CC chemokine receptor antagonist",-0.51865,-1.27,0.197,1072,0.528,"SB.225002, PF.04136309, navarixin",0.705533773838407,0.277366077466188,FALSE
+"H358","Pearson.est","CDK inhibitor",-0.5444,-1.32,0.141,1039,0.465,"TG.02, palbociclib, AZD5438, BMS.265246, NU6027, indisulam, JNJ.7706621, ribociclib, abemaciclib, kenpaullone, indirubin, R547, arcyriaflavin.a",0.85078088734462,0.332547047110046,FALSE
+"H358","Pearson.est","CHK inhibitor",0.51553,1.45,0.135,182,0.532,"SCH.900776, CHIR.124, LY2603618, LY2606368",0.869666231504994,0.274088367704952,FALSE
+"H358","Pearson.est","cyclooxygenase inhibitor",-0.30426,-0.736,0.8,944,0.934,"indoprofen, FK.3311, curcumin, tepoxalin, piroxicam, aspirin, pterostilbene, naproxen, FR.122047, tryptanthrin",0.0969100130080564,0.0296531237699066,FALSE
+"H358","Pearson.est","cytochrome P450 inhibitor",0.40963,1.2,0.232,237,0.694,"PF.4981517, morin, eplerenone, metyrapone",0.6345120151091,0.158640529545145,FALSE
+"H358","Pearson.est","DNA alkylating agent",-0.32362,-0.788,0.745,807,0.914,"streptozotocin, carboplatin, temozolomide, ifosfamide, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.127843727251707,0.0390538042661686,FALSE
+"H358","Pearson.est","DNA inhibitor",-0.35823,-0.876,0.637,841,0.867,"oxaliplatin, carboplatin, valrubicin, carmustine, metronidazole, tirapazamine, pibenzimol, melphalan, mechlorethamine, primaquine",0.19586056766465,0.0619809025237897,FALSE
+"H358","Pearson.est","DNA methyltransferase inhibitor",-0.38425,-0.924,0.575,1031,0.836,"fdcyd, RG108, disulfiram",0.24033215531037,0.0777937225609836,FALSE
+"H358","Pearson.est","DNA polymerase inhibitor",0.29583,0.844,0.591,1022,0.733,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, foscarnet, trifluridine, cidofovir",0.228412519118745,0.134896025358872,FALSE
+"H358","Pearson.est","DNA synthesis inhibitor",-0.30582,-0.744,0.793,769,0.941,"cyclocytidine, altretamine, azodicarbonamide, artesunate, anisomycin, estramustine.phosphate, CB.10.277, enocitabine, mitomycin.c",0.100726812682396,0.0264103765727431,FALSE
+"H358","Pearson.est","dopamine receptor antagonist",-0.4414,-1.07,0.376,1171,0.768,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.424812155072339,0.114638779968488,FALSE
+"H358","Pearson.est","estrogen receptor agonist",0.45019,1.33,0.156,176,0.53,"PPT, levonorgestrel, ethinyl.estradiol",0.806875401645538,0.275724130399211,FALSE
+"H358","Pearson.est","estrogen receptor antagonist",-0.65727,-1.61,0.0324,1267,0.899,"toremifene, danazol, fulvestrant",1.48945498979339,0.0462403082667712,FALSE
+"H358","Pearson.est","FGFR inhibitor",-0.57921,-1.38,0.109,1133,0.465,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",0.962573502059376,0.332547047110046,FALSE
+"H358","Pearson.est","FLT3 inhibitor",-0.60871,-1.46,0.073,1039,0.509,"TG.02, sunitinib, pacritinib, tandutinib, KW.2449, ENMD.2076, ponatinib, TG.101348, GTP.14564, sorafenib, quizartinib, tozasertib",1.13667713987954,0.293282217663241,FALSE
+"H358","Pearson.est","glucocorticoid receptor agonist",0.31466,0.864,0.587,319,0.742,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, ciclesonide, halcinonide, prednisolone, fludroxycortide, triamcinolone.acetonide",0.231361898752386,0.129596094720973,FALSE
+"H358","Pearson.est","glutamate receptor antagonist",0.31039,0.914,0.553,282,0.746,"SIB.1757, latrepirdine, kynurenic.acid, CGP.37849, JNJ.16259685, CPP",0.257274868695302,0.127261172527331,FALSE
+"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.55259,-1.35,0.131,1213,0.507,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, CHIR.98014, indirubin",0.882728704344236,0.294992040666664,FALSE
+"H358","Pearson.est","growth factor receptor inhibitor",-0.51515,-1.25,0.205,880,0.527,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.688246138944246,0.278189384787453,FALSE
+"H358","Pearson.est","HCV inhibitor",0.23781,0.693,0.877,69,0.927,"daclatasvir",0.0570004066339595,0.0329202658555029,FALSE
+"H358","Pearson.est","HDAC inhibitor",-0.5445,-1.33,0.134,1045,0.496,"entinostat, PCI.24781, dacinostat, panobinostat, scriptaid, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.872895201635192,0.304518323509803,FALSE
+"H358","Pearson.est","histamine receptor antagonist",-0.24304,-0.602,0.899,987,0.97,"cyproheptadine, tecastemizole, BF2.649, lafutidine, epinastine",0.0462403082667712,0.0132282657337552,FALSE
+"H358","Pearson.est","HMGCR inhibitor",-0.22758,-0.557,0.958,979,0.951,"fluvastatin, lovastatin",0.0186344909214556,0.0218194830625861,FALSE
+"H358","Pearson.est","HSP inhibitor",0.4815,1.42,0.114,286,0.471,"BIIB021, KW.2478, SNX.2112, SNX.5422, alvespimycin, NVP.AUY922, ganetespib, VER.49009",0.943095148663527,0.326979092871104,FALSE
+"H358","Pearson.est","JAK inhibitor",-0.4049,-0.975,0.487,975,0.862,"lestaurtinib, LY2784544, AZD1480, TG.02, pacritinib, TG.101348, AT.9283, TG.101209, tozasertib",0.312471038785366,0.0644927341752872,FALSE
+"H358","Pearson.est","KIT inhibitor",-0.42799,-1.02,0.453,1198,0.808,"lenvatinib, tandutinib, imatinib, sorafenib, KI.8751, masitinib",0.343901797987168,0.0925886392254138,FALSE
+"H358","Pearson.est","MDM inhibitor",-0.52506,-1.28,0.184,1164,0.529,"serdemetan, RITA",0.735182176990464,0.276544327964814,FALSE
+"H358","Pearson.est","MEK inhibitor",0.62941,1.78,0.0455,201,0.306,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, TAK.733, AZD8330, PD.198306, PD.0325901",1.34198860334289,0.51427857351842,FALSE
+"H358","Pearson.est","MET inhibitor",-0.59719,-1.44,0.0822,1401,0.463,"NVP.BVU972, AMG458",1.08512818245995,0.334419008982047,FALSE
+"H358","Pearson.est","microtubule inhibitor",-0.23995,-0.585,0.938,1334,0.966,"D.64131",0.0277971616209356,0.0150228735845067,FALSE
+"H358","Pearson.est","mTOR inhibitor",-0.44583,-1.08,0.374,757,0.77,"GDC.0980, NVP.BEZ235, PF.05212384, AZD8055, OSI.027, voxtalisib, PKI.179, WYE.125132, torin.2, sirolimus, MLN0128, LY303511, XL388, torin.1, LY3023414, PF.04691502, GSK2126458, ku.0063794, WYE.354, SB.2343, AZD2014",0.42712839779952,0.113509274827518,FALSE
+"H358","Pearson.est","NFkB pathway inhibitor",-0.39847,-0.973,0.502,1369,0.843,"EVP4593, betulinic.acid",0.299296282854981,0.0741724253752577,FALSE
+"H358","Pearson.est","opioid receptor agonist",-0.30186,-0.733,0.804,879,0.92,"salvinorin.a, trimebutine, cebranopadol",0.0947439512515487,0.0362121726544447,FALSE
+"H358","Pearson.est","p38 MAPK inhibitor",-0.50835,-1.22,0.242,1365,0.545,"SB.239063, skepinone.l",0.616184634019569,0.263603497723358,FALSE
+"H358","Pearson.est","PARP inhibitor",-0.63077,-1.54,0.036,1183,0.572,"AG.14361, PJ.34, E7449, niraparib",1.44369749923271,0.242603971206976,FALSE
+"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.46008,-1.11,0.322,1056,0.724,"sunitinib, linifanib, axitinib, crenolanib, lenvatinib, tandutinib, ponatinib, imatinib, sorafenib, KI.8751, masitinib",0.492144128304169,0.140261433802853,FALSE
+"H358","Pearson.est","phosphatase inhibitor",-0.41656,-1.01,0.455,680,0.808,"mycophenolic.acid, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, AS.1949490, BVT.948, CID.5458317, alexidine, GSK2830371",0.341988603342888,0.0925886392254138,FALSE
+"H358","Pearson.est","phosphodiesterase inhibitor",0.34145,0.993,0.429,957,0.757,"cilostamide, EMD.53998, anagrelide, enoximone, avanafil, papaverine, zardaverine, trequinsin, GSK256066, YM.976",0.367542707815276,0.120904120499927,FALSE
+"H358","Pearson.est","PI3K inhibitor",-0.38477,-0.932,0.548,874,0.841,"voxtalisib, PKI.179, BGT226, YM.201636, AZD6482, PI3K.IN.2, TG.100713, LY303511, LY3023414, PF.04691502, GDC.0941, GSK2126458, CUDC.907, SB.2343, CH5132799",0.261219441515631,0.0752040042020878,FALSE
+"H358","Pearson.est","PLK inhibitor",-0.31659,-0.76,0.771,720,0.937,"NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.112945621949043,0.0282604091122217,FALSE
+"H358","Pearson.est","potassium channel blocker",0.38121,1.1,0.313,132,0.745,"dofetilide, mepivacaine",0.504455662453552,0.127843727251707,FALSE
+"H358","Pearson.est","PPAR receptor agonist",-0.35137,-0.852,0.645,897,0.889,"GW.501516, pterostilbene",0.190440285364732,0.0510982390297863,FALSE
+"H358","Pearson.est","progesterone receptor agonist",-0.3603,-0.881,0.631,1338,0.878,"melengestrol.acetate, danazol",0.199970640755866,0.0565054840938974,FALSE
+"H358","Pearson.est","proteasome inhibitor",0.34431,0.991,0.462,113,0.701,"MG.132, carfilzomib",0.335358024443874,0.154281982033341,FALSE
+"H358","Pearson.est","protein synthesis inhibitor",-0.25952,-0.635,0.902,1371,0.959,"florfenicol, azomycin..2.nitroimidazole.",0.0447934624580583,0.0181813928293364,FALSE
+"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.38935,-0.936,0.544,1078,0.855,"NVP.TAE226, mubritinib, BMS.599626",0.26440110030182,0.0680338852718274,FALSE
+"H358","Pearson.est","RAF inhibitor",-0.29224,-0.708,0.841,1337,0.917,"sorafenib, TAK.632",0.0752040042020878,0.0376306643299789,FALSE
+"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.30192,-0.726,0.794,1056,0.912,"sunitinib, cabozantinib, sorafenib",0.100179497572904,0.0400051616715838,FALSE
+"H358","Pearson.est","retinoid receptor agonist",-0.65106,-1.59,0.0345,1312,0.686,"adapalene, fenretinide, bexarotene",1.46218090492673,0.163675884293248,FALSE
+"H358","Pearson.est","ribonucleotide reductase inhibitor",-0.34825,-0.845,0.66,838,0.881,"clofarabine, cytarabine, fludarabine, cladribine, pentostatin",0.180456064458131,0.0550240915879521,FALSE
+"H358","Pearson.est","serotonin receptor agonist",-0.58377,-1.42,0.0883,1225,0.472,"ipsapirone, aripiprazole",1.05403929642243,0.326058001365912,FALSE
+"H358","Pearson.est","serotonin receptor antagonist",-0.50702,-1.23,0.219,1374,0.544,"lurasidone, aripiprazole",0.659555885159882,0.26440110030182,FALSE
+"H358","Pearson.est","sodium channel blocker",-0.42192,-1.03,0.437,1237,0.811,"triamterene, quinidine, ajmaline, lappaconite",0.359518563029578,0.090979145788844,FALSE
+"H358","Pearson.est","src inhibitor",0.37597,1.07,0.338,20,0.668,"dasatinib, saracatinib",0.471083299722345,0.175223537524454,FALSE
+"H358","Pearson.est","sterol demethylase inhibitor",-0.58877,-1.4,0.0922,1047,0.451,"terconazole, ketoconazole",1.03526907894637,0.345823458122039,FALSE
+"H358","Pearson.est","TGF beta receptor inhibitor",-0.31905,-0.79,0.74,1359,0.93,"adaprev",0.130768280269024,0.0315170514460649,FALSE
+"H358","Pearson.est","thymidylate synthase inhibitor",0.37308,1.08,0.316,232,0.711,"capecitabine, doxifluridine, ftorafur",0.500312917381596,0.148130399270234,FALSE
+"H358","Pearson.est","topoisomerase inhibitor",-0.36856,-0.901,0.571,873,0.859,"topotecan, valrubicin, camptothecin, nemorubicin, etoposide.phosphate, voreloxin, fleroxacin, rubitecan, SN.38, TAS.103, dexrazoxane, genz.644282, irinotecan",0.243363891754152,0.0660068361687577,FALSE
+"H358","Pearson.est","tubulin polymerization inhibitor",0.14547,0.411,1,5,0.998,"mebendazole",0,0.000869458712628891,FALSE
+"H358","Pearson.est","tyrosine kinase inhibitor",-0.28411,-0.688,0.874,1056,0.923,"sunitinib, cabozantinib, NVP.TAE226, mubritinib, BMS.599626, GTP.14564, sorafenib, UNC2250",0.058488567365597,0.0347982989740879,FALSE
+"H358","Pearson.est","VEGFR inhibitor",-0.33972,-0.823,0.706,1056,0.898,"sunitinib, cabozantinib, linifanib, RAF265, axitinib, PD.173074, MK.2461, lenvatinib, ENMD.2076, tivozanib, MGCD.265, sorafenib, lucitanib, KI.8751",0.151195298948196,0.0467236633326956,FALSE
+"H358","Pearson.est","vitamin D receptor agonist",-0.57068,-1.4,0.0943,1279,0.451,"maxacalcitol, paricalcitol, tacalcitol",1.02548830726267,0.345823458122039,FALSE
+"H1650","Pearson.est","EGFR inhibitor",0.42459,1.2,0.237,225,0.51,"pelitinib, canertinib, afatinib, XL.647, vandetanib, brigatinib, BMS.690514, rociletinib, erlotinib, CUDC.101, dacomitinib, AZD8931, neratinib, lapatinib, poziotinib, PD.168393, AEE788",0.625251653989896,0.292429823902064,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",-0.5425,-1.33,0.149,1063,0.62,"metatinib, KW.2449, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.826813731587726,0.207608310501746,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",-0.45659,-1.12,0.331,1151,0.624,"nicotine, nefiracetam, pilocarpine",0.480172006224281,0.204815410317576,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.5,-1.21,0.235,721,0.677,"hyoscyamine, darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.628932137728264,0.169411331314856,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",-0.54559,-1.33,0.149,901,0.62,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.826813731587726,0.207608310501746,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.40619,-0.99,0.508,750,0.74,"midodrine, metaraminol, xylazine, methyldopa, ritodrine, A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.294136287716081,0.130768280269024,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.43388,1.21,0.23,276,0.604,"prazosin, vincamine, RS.17053, practolol, levobunolol, dihydroergocristine, imiloxan, idazoxan, atenolol....",0.638272163982407,0.218963061378868,FALSE
+"H1650","Pearson.est","AKT inhibitor",-0.39566,-0.967,0.487,1116,0.763,"ONC201, uprosertib, A.674563, CCT128930",0.312471038785366,0.11747546204512,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.30112,-0.73,0.829,1213,0.892,"AP26113, alectinib, DMH1",0.0814454694497265,0.0496351456238769,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.54233,-1.31,0.158,992,0.637,"nilutamide, flutamide, bicalutamide",0.801342913045577,0.19586056766465,FALSE
+"H1650","Pearson.est","antioxidant",-0.48184,-1.15,0.286,1322,0.675,"benfotiamine, trolox",0.543633966870957,0.170696227168975,FALSE
+"H1650","Pearson.est","AP inhibitor",0.54764,1.55,0.0945,60,0.86,"birinapant, GDC.0152",1.02456819149074,0.0655015487564323,FALSE
+"H1650","Pearson.est","ATPase inhibitor",0.23444,0.65,0.908,282,1,"k.strophanthidin, digitoxin, blebbistatin...., ouabain",0.0419141514789149,0,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",-0.55976,-1.37,0.123,1076,0.805,"AMG900, SNS.314, KW.2449, CCT129202, AT.9283, aurora.a.inhibitor.i, MK.8745, PF.03814735, barasertib, ENMD.2076, hesperadin, tozasertib",0.910094888560602,0.0942041196321315,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.49327,-1.22,0.216,1035,0.685,"josamycin, tilmicosin, radezolid, dirithromycin",0.665546248849069,0.164309428507574,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.47315,1.33,0.144,184,0.62,"novobiocin, finafloxacin, sarafloxacin",0.84163750790475,0.207608310501746,FALSE
+"H1650","Pearson.est","BCL inhibitor",-0.41492,-1.01,0.452,1031,0.721,"gossypol, ABT.737",0.344861565188618,0.142064735280571,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",-0.54162,-1.3,0.167,1063,0.622,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.777283528852417,0.206209615309181,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",0.22733,0.649,0.9,74,0.964,"ZK.93423, gamma.aminobutyric.acid",0.0457574905606751,0.0159229660971692,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",-0.46154,-1.13,0.317,932,0.625,"JQ1...., PFI.1, bromosporine, I.BET151",0.498940737782249,0.204119982655925,FALSE
+"H1650","Pearson.est","calcium channel blocker",-0.55487,-1.35,0.13,1218,0.722,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.886056647693163,0.141462802430361,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",-0.46291,-1.13,0.326,754,0.625,"UNBS.5162, MK.0812, RS.504393, SB.225002, PF.04136309, navarixin",0.486782399932061,0.204119982655925,FALSE
+"H1650","Pearson.est","CDK inhibitor",-0.30902,-0.754,0.771,1089,0.893,"abemaciclib, ribociclib, kenpaullone, NU6027, R547, indirubin, arcyriaflavin.a",0.112945621949043,0.0491485411114536,FALSE
+"H1650","Pearson.est","CHK inhibitor",0.52087,1.48,0.0664,92,0.555,"SCH.900776, CHIR.124, LY2603618",1.17783192063198,0.255707016877324,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",-0.29618,-0.707,0.831,1003,0.887,"tepoxalin, piroxicam, FK.3311, metoxibutropate, indoprofen, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.080398976215889,0.0520763801682736,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",0.22317,0.632,0.924,296,0.902,"PF.4981517, morin, eplerenone",0.0343280287798933,0.0447934624580583,FALSE
+"H1650","Pearson.est","DNA alkylating agent",-0.38774,-0.939,0.55,1047,0.776,"carmustine, temozolomide, cyclophosphamide, carboplatin, melphalan, satraplatin, mitomycin.c",0.259637310505756,0.110138278741812,FALSE
+"H1650","Pearson.est","DNA inhibitor",-0.44238,-1.08,0.372,1047,0.628,"carmustine, pibenzimol, primaquine, carboplatin, melphalan, tirapazamine, metronidazole, mechlorethamine",0.429457060118102,0.202040356262804,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.33916,0.933,0.5,228,0.867,"decitabine, SGI.1027, azacitidine",0.301029995663981,0.0619809025237897,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",0.30903,0.869,0.651,1003,0.836,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.186419011431808,0.0777937225609836,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",-0.35591,-0.872,0.615,793,0.802,"cisplatin, nelarabine, azodicarbonamide, artesunate, estramustine.phosphate, enocitabine, altretamine, CB.10.277, mitomycin.c",0.211124884224583,0.0958256317158365,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",-0.42633,-1.05,0.428,747,0.664,"clebopride, oxiperomide, ziprasidone, raclopride, domperidone, amisulpride, paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.368556230986828,0.177831920631982,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",0.4752,1.34,0.152,30,0.719,"PPT, levonorgestrel",0.818156412055227,0.143271109617117,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",-0.74426,-1.8,0.0069,1268,0.396,"toremifene, fulvestrant, danazol",2.16115090926274,0.402304814074488,FALSE
+"H1650","Pearson.est","FGFR inhibitor",-0.61889,-1.49,0.0519,1037,0.77,"orantinib, PD.173074, lucitanib, lenvatinib, MK.2461, erdafitinib",1.28483264215154,0.113509274827518,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",-0.63389,-1.51,0.0547,1096,0.857,"midostaurin, KW.2449, sunitinib, sorafenib, TG.101348, tandutinib, GTP.14564, ENMD.2076, quizartinib, ponatinib, tozasertib",1.26201267366657,0.0670191780768018,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",0.45273,1.26,0.183,279,0.578,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, triamcinolone.acetonide, fluocinolone.acetonide, fludroxycortide, halcinonide, desonide",0.737548910269571,0.238072161579471,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",0.25111,0.707,0.813,100,0.98,"SIB.1757, latrepirdine",0.0899094544059319,0.00877392430750515,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.54843,-1.33,0.15,1202,0.62,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin, CHIR.98014",0.823908740944319,0.207608310501746,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",-0.51855,-1.26,0.187,774,0.652,"GSK1904529A, AZD3463, lestaurtinib, GSK1838705A, GW.441756",0.728158393463501,0.18575240426808,FALSE
+"H1650","Pearson.est","HCV inhibitor",-0.36197,-0.874,0.602,1305,0.817,"narlaprevir",0.220403508742175,0.0877779434675845,FALSE
+"H1650","Pearson.est","HDAC inhibitor",-0.4644,-1.14,0.313,1126,0.673,"AR.42, panobinostat, givinostat, trichostatin.a, vorinostat, resminostat, M.344, RG2833, R306465, RGFP966",0.504455662453552,0.171984935776023,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",-0.37707,-0.92,0.569,1198,0.792,"BF2.649, lafutidine, tecastemizole, epinastine",0.244887733604929,0.101274818410506,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.55585,-1.36,0.115,1285,0.758,"lovastatin, fluvastatin",0.939302159646388,0.120330794367946,FALSE
+"H1650","Pearson.est","HSP inhibitor",0.55286,1.52,0.0785,293,0.643,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, VER.49009, ganetespib",1.10513034325475,0.191789027075778,FALSE
+"H1650","Pearson.est","JAK inhibitor",-0.33795,-0.812,0.705,864,0.883,"WHI.P154, LY2784544, lestaurtinib, CEP.33779, AT.9283, AZD1480, TG.101348, TG.101209, tozasertib",0.151810883008601,0.0540392964224314,FALSE
+"H1650","Pearson.est","KIT inhibitor",-0.49765,-1.2,0.248,1096,0.671,"midostaurin, sunitinib, sorafenib, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.605548319173784,0.173277479831008,FALSE
+"H1650","Pearson.est","MDM inhibitor",-0.4558,-1.11,0.371,1352,0.624,"RITA",0.430626090384954,0.204815410317576,FALSE
+"H1650","Pearson.est","MEK inhibitor",0.67269,1.87,0.0123,176,0.477,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.9100948885606,0.321481620959886,FALSE
+"H1650","Pearson.est","MET inhibitor",-0.6643,-1.61,0.0301,1411,0.899,"NVP.BVU972, AMG458",1.52143350440616,0.0462403082667712,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.22462,0.636,0.919,1125,0.936,"secnidazole, triclabendazole, vinflunine, podophyllotoxin, vinblastine, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0366844886138887,0.0287241512618947,FALSE
+"H1650","Pearson.est","mTOR inhibitor",-0.45002,-1.08,0.373,810,0.628,"temsirolimus, deforolimus, NVP.BEZ235, PKI.179, torin.2, OSI.027, voxtalisib, MLN0128, LY303511, sirolimus, XL388, GSK2126458, PF.04691502, torin.1, ku.0063794, LY3023414, WYE.354, AZD2014, SB.2343",0.428291168191312,0.202040356262804,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",-0.30137,-0.727,0.805,812,0.879,"parthenolide, curcumin, bortezomib, bindarit, EVP4593, betulinic.acid",0.0942041196321315,0.0560111249262281,FALSE
+"H1650","Pearson.est","opioid receptor agonist",-0.50057,-1.22,0.241,876,0.685,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.617982957425132,0.164309428507574,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",-0.51628,-1.27,0.2,1004,0.663,"SB.242235, TAK.715, SB.239063, skepinone.l",0.698970004336019,0.178486471595227,FALSE
+"H1650","Pearson.est","PARP inhibitor",-0.60004,-1.48,0.0695,1163,0.681,"AG.14361, niraparib, PJ.34, E7449",1.15801519540989,0.166852888087215,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49183,-1.19,0.259,1037,0.637,"orantinib, crenolanib, sunitinib, axitinib, sorafenib, linifanib, imatinib, tandutinib, lenvatinib, ponatinib, KI.8751, masitinib",0.586700235918748,0.19586056766465,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",-0.47754,-1.16,0.295,928,0.679,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, GSK2830371, BVT.948",0.530177984021837,0.168130225719498,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",0.24965,0.713,0.789,1089,1,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, trequinsin, zardaverine, YM.976, GSK256066",0.10292299679058,0,FALSE
+"H1650","Pearson.est","PI3K inhibitor",-0.39275,-0.956,0.504,781,0.764,"pilaralisib, PI.828, NVP.BEZ235, PI3K.IN.2, PKI.179, TG.100713, voxtalisib, TG100.115, BGT226, LY303511, AZD6482, GSK2126458, CUDC.907, PF.04691502, LY3023414, GDC.0941, CH5132799, SB.2343",0.297569463554475,0.11690664142431,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.30673,0.874,0.573,1006,0.878,"HMN.214, GSK461364, BI.2536, NMS.1286937, volasertib, rigosertib, GW.843682X",0.24184537803261,0.0565054840938974,FALSE
+"H1650","Pearson.est","potassium channel blocker",-0.23605,-0.57,0.941,947,0.978,"ML133, ibutilide, meglitinide",0.0264103765727431,0.00966114521239857,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",-0.37035,-0.903,0.584,1291,0.804,"pterostilbene",0.233587152887601,0.0947439512515487,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",-0.32688,-0.803,0.735,1288,0.861,"melengestrol.acetate, danazol",0.133712660915805,0.0649968485463452,FALSE
+"H1650","Pearson.est","proteasome inhibitor",0.43607,1.2,0.237,85,0.51,"MG.132, carfilzomib",0.625251653989896,0.292429823902064,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.37826,1.04,0.399,107,0.759,"homoharringtonine, bruceantin, cycloheximide, anguidine, chloramphenicol.palmitate, clofoctol",0.399027104313252,0.11975822410452,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",-0.28628,-0.705,0.828,1087,0.873,"mubritinib, BMS.599626",0.0819696632151199,0.0589857562944303,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.28005,0.775,0.775,101,0.968,"AZ.628, vemurafenib, LGX818",0.11069829749369,0.0141246426916063,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.31141,-0.757,0.761,910,0.907,"apatinib, cabozantinib, sunitinib, sorafenib",0.118615343229427,0.0423927129399047,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",-0.48763,-1.19,0.252,1215,0.637,"fenretinide, adapalene, bexarotene",0.598599459218456,0.19586056766465,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",-0.31274,-0.749,0.775,803,0.883,"fludarabine, clofarabine, hydroxyurea, cytarabine, cladribine, pentostatin",0.11069829749369,0.0540392964224314,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",-0.56616,-1.39,0.121,1316,0.938,"ipsapirone, aripiprazole",0.91721462968355,0.0277971616209356,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",-0.46722,-1.13,0.32,1351,0.625,"lurasidone, aripiprazole",0.494850021680094,0.204119982655925,FALSE
+"H1650","Pearson.est","sodium channel blocker",-0.45897,-1.1,0.347,993,0.626,"cibenzoline, A.803467, oxcarbazepine, ajmaline, triamterene, quinidine, lappaconite",0.459670525209126,0.20342566678957,FALSE
+"H1650","Pearson.est","src inhibitor",0.3346,0.932,0.489,22,0.811,"saracatinib, dasatinib",0.31069114087638,0.090979145788844,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",-0.61916,-1.52,0.0553,1185,1,"terconazole, ketoconazole",1.2572748686953,0,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.36906,-0.895,0.576,1384,0.8,"adaprev",0.239577516576788,0.0969100130080564,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.46542,1.3,0.143,99,0.587,"capecitabine, doxifluridine",0.844663962534938,0.231361898752386,FALSE
+"H1650","Pearson.est","topoisomerase inhibitor",-0.22291,-0.549,0.946,787,0.973,"topotecan, voreloxin, camptothecin, valrubicin, nemorubicin, etoposide.phosphate, rubitecan, SN.38, TAS.103, genz.644282, dexrazoxane, fleroxacin, irinotecan",0.0241088635982073,0.0118871597316481,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.35078,0.982,0.46,364,0.824,"mebendazole, CYT.997, paclitaxel, BNC105, vincristine, vindesine, taltobulin, epothilone.b, vinorelbine, oxibendazole, fosbretabulin, verubulin, dolastatin.10, fenbendazole",0.337242168318426,0.0840727883028842,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",-0.21991,-0.533,0.966,1070,0.965,"cabozantinib, mubritinib, sunitinib, sorafenib, BMS.599626, GTP.14564, UNC2250",0.0150228735845067,0.0154726866562074,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",-0.33358,-0.81,0.702,1037,0.868,"orantinib, RAF265, cabozantinib, sunitinib, PD.173074, axitinib, sorafenib, linifanib, lucitanib, lenvatinib, MK.2461, ENMD.2076, MGCD.265, tivozanib, KI.8751",0.153662887870195,0.0614802748235081,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.55625,-1.38,0.107,1183,0.86,"maxacalcitol, paricalcitol, tacalcitol",0.97061622231479,0.0655015487564323,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",0.40029,1.11,0.281,187,0.674,"canertinib, pelitinib, BMS.690514, brigatinib, erlotinib, vandetanib, XL.647, afatinib, rociletinib, CUDC.101, AZD8931, neratinib, dacomitinib, PD.168393, lapatinib",0.55129368009492,0.17134010346468,FALSE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.55118,-1.34,0.149,1052,0.6,"metatinib, flumatinib, nilotinib, KW.2449, imatinib, ponatinib, tozasertib",0.826813731587726,0.221848749616356,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",-0.47506,-1.18,0.265,1181,0.548,"nicotine, nefiracetam, pilocarpine",0.576754126063192,0.261219441515631,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.57666,-1.41,0.0978,1071,0.862,"dicycloverine, iododexetimide, methscopolamine",1.0096611452124,0.0644927341752872,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",-0.50479,-1.23,0.232,976,0.53,"istradefylline, CGS.15943, MRS.1220, SCH.58261",0.6345120151091,0.275724130399211,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",-0.48151,-1.18,0.272,1123,0.548,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.565431095965801,0.261219441515631,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",0.45575,1.3,0.149,257,0.584,"prazosin, vincamine, RS.17053, practolol, levobunolol, imiloxan, dihydroergocristine, atenolol...., idazoxan",0.826813731587726,0.233587152887601,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.50086,-1.21,0.254,1225,0.548,"ONC201, uprosertib, A.674563, CCT128930",0.595166283380062,0.261219441515631,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.26846,-0.654,0.887,1204,0.925,"alectinib, AP26113, DMH1",0.0520763801682736,0.0338582672609674,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",-0.57143,-1.4,0.107,1002,0.708,"nilutamide, flutamide, bicalutamide",0.97061622231479,0.149966742310231,FALSE
+"HCC95","Pearson.est","antioxidant",-0.49417,-1.18,0.283,1328,0.548,"benfotiamine, trolox",0.54821356447571,0.261219441515631,FALSE
+"HCC95","Pearson.est","AP inhibitor",0.55424,1.59,0.052,53,0.794,"birinapant, GDC.0152",1.2839966563652,0.100179497572904,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",0.27405,0.781,0.7,232,0.952,"k.strophanthidin, ouabain, digitoxin, blebbistatin....",0.154901959985743,0.0213630516155257,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",-0.58542,-1.43,0.11,1077,0.902,"barasertib.HQPA, CCT129202, AT.9283, aurora.a.inhibitor.i, AMG900, SNS.314, KW.2449, MK.8745, PF.03814735, ENMD.2076, barasertib, hesperadin, tozasertib",0.958607314841775,0.0447934624580583,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53302,-1.29,0.173,806,0.581,"valnemulin, azithromycin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.761953896871205,0.235823867609669,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.50667,1.4,0.138,133,0.747,"finafloxacin, sarafloxacin, novobiocin",0.860120913598763,0.126679398184601,FALSE
+"HCC95","Pearson.est","BCL inhibitor",-0.51576,-1.24,0.216,1199,0.606,"gossypol, ABT.737",0.665546248849069,0.217527375833714,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.53868,-1.33,0.163,1052,0.549,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.787812395596042,0.260427655549908,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",0.26377,0.753,0.746,50,0.903,"ZK.93423, gamma.aminobutyric.acid",0.127261172527331,0.0443122496864942,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",-0.56203,-1.35,0.132,1065,0.668,"JQ1...., PFI.1, I.BET151, bromosporine",0.87942606879415,0.175223537524454,FALSE
+"HCC95","Pearson.est","calcium channel blocker",-0.54724,-1.33,0.14,1209,0.549,"cinnarazine, mibefradil, carboxyamidotriazole, SR.33805",0.853871964321762,0.260427655549908,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.36195,-0.884,0.612,737,0.837,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.213248577854439,0.07727454200674,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.39096,-0.953,0.513,942,0.754,"AZD5438, palbociclib, BMS.265246, JNJ.7706621, indisulam, ribociclib, kenpaullone, abemaciclib, NU6027, R547, indirubin, arcyriaflavin.a",0.289882634888184,0.122628654130226,FALSE
+"HCC95","Pearson.est","CHK inhibitor",0.47175,1.31,0.148,149,0.657,"SCH.900776, CHIR.124, LY2603618",0.829738284605043,0.182434630440219,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.29145,-0.71,0.824,910,0.898,"meloxicam, curcumin, naproxen, metoxibutropate, piroxicam, aspirin, FK.3311, indoprofen, tepoxalin, pterostilbene, FR.122047, tryptanthrin",0.0840727883028842,0.0467236633326956,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.23857,0.657,0.864,353,0.908,"PF.4981517, morin, eplerenone, metyrapone",0.0634862575211067,0.0419141514789149,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.40624,-0.989,0.471,895,0.742,"temozolomide, ifosfamide, streptozotocin, carboplatin, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.326979092871104,0.129596094720973,FALSE
+"HCC95","Pearson.est","DNA inhibitor",-0.45822,-1.11,0.351,1035,0.623,"carboplatin, tirapazamine, carmustine, primaquine, metronidazole, pibenzimol, melphalan, mechlorethamine",0.454692883534176,0.20551195334083,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.35786,-0.868,0.644,1271,0.826,"RG108, disulfiram",0.191114132640188,0.0830199526796178,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",0.30069,0.834,0.59,1015,1,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.229147988357856,0,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.33834,-0.825,0.69,758,0.806,"anisomycin, nelarabine, cisplatin, artesunate, azodicarbonamide, estramustine.phosphate, CB.10.277, altretamine, enocitabine, mitomycin.c",0.161150909262745,0.0936649581949093,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",-0.42318,-1.03,0.431,985,0.743,"raclopride, amisulpride, UH.232...., paliperidone, nemonapride, lurasidone, mesoridazine",0.365522729839268,0.129011186239425,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",0.44615,1.24,0.211,33,0.621,"levonorgestrel, PPT",0.675717544702307,0.20690839982342,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",-0.69692,-1.69,0.0219,1244,0.53,"toremifene, fulvestrant, danazol",1.65955588515988,0.275724130399211,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",-0.58217,-1.4,0.0938,1022,0.708,"orantinib, PD.173074, lenvatinib, MK.2461, erdafitinib, lucitanib",1.02779716162094,0.149966742310231,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",-0.63292,-1.54,0.0456,1101,0.992,"midostaurin, tandutinib, sunitinib, TG.101348, KW.2449, GTP.14564, sorafenib, ENMD.2076, quizartinib, ponatinib, tozasertib",1.34103515733556,0.00348832784582135,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",0.48436,1.36,0.115,271,0.679,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, halcinonide, fluocinolone.acetonide, triamcinolone.acetonide, desonide, fludroxycortide",0.939302159646388,0.168130225719498,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",0.29559,0.824,0.69,61,0.978,"SIB.1757, latrepirdine",0.161150909262745,0.00966114521239857,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",-0.50413,-1.23,0.225,1150,0.53,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, CHIR.98014, indirubin",0.647817481888638,0.275724130399211,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.51633,-1.23,0.235,786,0.53,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.628932137728264,0.275724130399211,FALSE
+"HCC95","Pearson.est","HCV inhibitor",0.29728,0.82,0.69,64,0.931,"daclatasvir",0.161150909262745,0.0310503190186574,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.55162,-1.34,0.152,1075,0.6,"PCI.24781, entinostat, dacinostat, AR.42, panobinostat, vorinostat, trichostatin.a, givinostat, M.344, RG2833, R306465, resminostat, RGFP966",0.818156412055227,0.221848749616356,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",-0.35967,-0.878,0.625,1183,0.828,"BF2.649, tecastemizole, lafutidine, epinastine",0.204119982655925,0.0819696632151199,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",-0.40853,-0.989,0.486,1145,0.742,"fluvastatin, lovastatin",0.313363730737707,0.129596094720973,FALSE
+"HCC95","Pearson.est","HSP inhibitor",0.53932,1.46,0.106,311,0.809,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, VER.49009, NVP.AUY922",0.97469413473523,0.0920514783877277,FALSE
+"HCC95","Pearson.est","JAK inhibitor",-0.31264,-0.758,0.769,867,0.871,"lestaurtinib, pacritinib, CEP.33779, LY2784544, AZD1480, AT.9283, TG.101348, TG.101209, tozasertib",0.114073660198569,0.0599818449923368,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.52729,-1.27,0.196,1061,0.596,"telatinib, midostaurin, tandutinib, sunitinib, sorafenib, lenvatinib, imatinib, KI.8751, masitinib",0.707743928643524,0.224753740259764,FALSE
+"HCC95","Pearson.est","MDM inhibitor",-0.34788,-0.839,0.666,1092,0.818,"serdemetan, RITA",0.176525770829699,0.087246696328677,FALSE
+"HCC95","Pearson.est","MEK inhibitor",0.68065,1.93,0.0112,127,0.363,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, AZD8330, cobimetinib, TAK.733, PD.198306, PD.0325901",1.95078197732982,0.440093374963888,FALSE
+"HCC95","Pearson.est","MET inhibitor",-0.77155,-1.88,0,1424,0.18,"NVP.BVU972, AMG458",Inf,0.744727494896694,TRUE
+"HCC95","Pearson.est","microtubule inhibitor",-0.1864,-0.451,0.989,1073,0.991,"estramustine.phosphate, D.64131",0.0048037084028206,0.00392634551472468,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.41782,-1.03,0.422,800,0.743,"temsirolimus, PKI.179, voxtalisib, NVP.BEZ235, OSI.027, torin.2, MLN0128, LY303511, sirolimus, XL388, GSK2126458, LY3023414, PF.04691502, torin.1, ku.0063794, AZD2014, WYE.354, SB.2343",0.374687549038326,0.129011186239425,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",-0.28526,-0.703,0.836,834,0.89,"bindarit, parthenolide, bortezomib, curcumin, EVP4593, betulinic.acid",0.0777937225609836,0.0506099933550872,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",-0.4795,-1.16,0.294,925,0.547,"salvinorin.a, ADL5859, trimebutine, cebranopadol",0.531652669587843,0.262012673666569,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",-0.40585,-0.977,0.466,1280,0.746,"SB.239063, skepinone.l",0.33161408331,0.127261172527331,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.56347,-1.38,0.127,1104,0.699,"AG.14361, niraparib, PJ.34, E7449",0.896196279044043,0.155522824254319,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.5222,-1.26,0.183,1022,0.588,"orantinib, telatinib, crenolanib, tandutinib, sunitinib, linifanib, axitinib, sorafenib, lenvatinib, imatinib, ponatinib, KI.8751, masitinib",0.737548910269571,0.230622673923862,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",-0.47928,-1.17,0.247,843,0.547,"AS.1949490, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, GSK2830371, BVT.948",0.607303046740334,0.262012673666569,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.20472,0.581,0.934,171,0.94,"cilostamide, EMD.53998",0.0296531237699066,0.0268721464003014,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.41224,-0.989,0.481,803,0.742,"PKI.179, YM.201636, voxtalisib, NVP.BEZ235, pilaralisib, AZD6482, TG.100713, TG100.115, BGT226, PI3K.IN.2, LY303511, GSK2126458, LY3023414, PF.04691502, GDC.0941, CUDC.907, CH5132799, SB.2343",0.317854923626168,0.129596094720973,FALSE
+"HCC95","Pearson.est","PLK inhibitor",0.27134,0.765,0.722,1057,0.93,"HMN.214, NMS.1286937, GSK461364, BI.2536, volasertib, rigosertib, GW.843682X",0.141462802430361,0.0315170514460649,FALSE
+"HCC95","Pearson.est","potassium channel blocker",0.25413,0.705,0.808,290,0.886,"dofetilide, oleoylethanolamide, mepivacaine",0.0925886392254138,0.0525662781129492,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",-0.3419,-0.834,0.666,1286,0.809,"pterostilbene",0.176525770829699,0.0920514783877277,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",-0.34019,-0.84,0.664,1288,0.834,"melengestrol.acetate, danazol",0.177831920631982,0.0788339493622613,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",0.40558,1.11,0.303,112,0.674,"MG.132, carfilzomib",0.518557371497695,0.17134010346468,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",0.31632,0.878,0.592,301,0.993,"clofoctol, cycloheximide, homoharringtonine, bruceantin, chloramphenicol.palmitate, anguidine, methacycline, puromycin, harringtonine",0.22767829327708,0.00305075150461883,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.29791,-0.715,0.828,691,0.909,"tyrphostin.A9, PP.121, rheochrysidin, NVP.TAE226, mubritinib, BMS.599626",0.0819696632151199,0.0414361167780325,FALSE
+"HCC95","Pearson.est","RAF inhibitor",0.26731,0.742,0.744,99,0.876,"vemurafenib, AZ.628, LGX818",0.128427064454121,0.0574958938319193,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.41429,-1.02,0.453,1154,0.743,"sunitinib, cabozantinib, sorafenib",0.343901797987168,0.129011186239425,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.59462,-1.44,0.0933,1320,1,"adapalene, bexarotene, fenretinide",1.0301183562535,0,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.32701,-0.81,0.699,877,0.812,"hydroxyurea, clofarabine, fludarabine, cladribine, pentostatin",0.155522824254319,0.0904439707588247,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.60681,-1.48,0.0774,1001,1,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",1.11125903931711,0,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",-0.50267,-1.23,0.248,1178,0.53,"paliperidone, lurasidone, aripiprazole",0.605548319173784,0.275724130399211,FALSE
+"HCC95","Pearson.est","sodium channel blocker",-0.39499,-0.968,0.505,1226,0.745,"ajmaline, quinidine, triamterene, lappaconite",0.296708621881339,0.127843727251707,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.34836,-0.847,0.644,1142,0.841,"KX2.391, PP.1, masitinib",0.191114132640188,0.0752040042020878,FALSE
+"HCC95","Pearson.est","sterol demethylase inhibitor",-0.55363,-1.36,0.127,1162,0.698,"terconazole, ketoconazole",0.896196279044043,0.156144577376839,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",0.39919,1.1,0.319,92,0.638,"repsox, SB.525334",0.496209316942819,0.195179321278838,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",0.43664,1.19,0.249,135,0.649,"capecitabine, doxifluridine",0.603800652904264,0.187755303199631,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",-0.25514,-0.617,0.911,858,0.942,"topotecan, valrubicin, camptothecin, etoposide.phosphate, nemorubicin, SN.38, TAS.103, rubitecan, genz.644282, dexrazoxane, fleroxacin, irinotecan",0.0404816230270017,0.0259490972071227,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",0.30916,0.889,0.554,270,1,"mebendazole, CYT.997, vincristine, paclitaxel, BNC105, vindesine, oxibendazole, epothilone.b",0.25649023527157,0,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.22179,-0.531,0.954,1140,0.982,"BMS.599626, sunitinib, cabozantinib, GTP.14564, sorafenib, UNC2250",0.0204516252959049,0.00788851221305034,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.37564,-0.898,0.588,1022,0.83,"orantinib, RAF265, telatinib, PD.173074, sunitinib, cabozantinib, linifanib, axitinib, sorafenib, ENMD.2076, lenvatinib, MK.2461, lucitanib, tivozanib, MGCD.265, KI.8751",0.230622673923862,0.0809219076239261,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",-0.54349,-1.32,0.15,1191,0.539,"maxacalcitol, paricalcitol, tacalcitol",0.823908740944319,0.268411234813261,FALSE
+"H3255","Pearson.est","EGFR inhibitor",0.49584,1.37,0.141,241,0.593,"canertinib, pelitinib, BMS.690514, XL.647, afatinib, erlotinib, rociletinib, vandetanib, brigatinib, AZD8931, CUDC.101, dacomitinib, lapatinib, neratinib, poziotinib, PD.168393, gefitinib, AEE788, osimertinib",0.85078088734462,0.226945306635737,FALSE
+"H3255","Pearson.est","Abl kinase inhibitor",-0.46955,-1.18,0.255,1090,0.617,"KW.2449, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.593459819566045,0.209714835966758,FALSE
+"H3255","Pearson.est","acetylcholine receptor agonist",-0.51262,-1.24,0.224,1223,0.776,"nefiracetam, nicotine, pilocarpine",0.649751981665837,0.110138278741812,FALSE
+"H3255","Pearson.est","acetylcholine receptor antagonist",-0.62081,-1.53,0.0552,1175,0.524,"dicycloverine, methscopolamine, iododexetimide",1.2580609222708,0.280668713016273,FALSE
+"H3255","Pearson.est","adenosine receptor antagonist",-0.42874,-1.02,0.459,760,0.757,"CGS.15943, sulmazole, istradefylline, MRS.1220, SCH.58261",0.338187314462739,0.120904120499927,FALSE
+"H3255","Pearson.est","adrenergic receptor agonist",-0.47998,-1.17,0.283,1207,0.591,"isoxsuprine, A61603, isoetharine, buphenine, norepinephrine",0.54821356447571,0.228412519118745,FALSE
+"H3255","Pearson.est","adrenergic receptor antagonist",0.40234,1.14,0.291,277,0.493,"prazosin, vincamine, RS.17053, practolol, dihydroergocristine, levobunolol, idazoxan, imiloxan",0.536107011014093,0.30715308072277,FALSE
+"H3255","Pearson.est","AKT inhibitor",-0.36232,-0.877,0.615,1045,0.834,"uprosertib, ONC201, A.674563, CCT128930",0.211124884224583,0.0788339493622613,FALSE
+"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31672,-0.775,0.756,1240,0.847,"alectinib, AP26113, DMH1",0.121478204498793,0.0721165896692931,FALSE
+"H3255","Pearson.est","androgen receptor antagonist",-0.63481,-1.55,0.0564,1125,0.697,"nilutamide, flutamide, bicalutamide",1.24872089601666,0.156767221901991,FALSE
+"H3255","Pearson.est","antioxidant",-0.55511,-1.36,0.144,1352,0.683,"benfotiamine, trolox",0.84163750790475,0.165579296318467,FALSE
+"H3255","Pearson.est","AP inhibitor",0.5637,1.59,0.0726,59,0.542,"birinapant, GDC.0152",1.13906337929991,0.266000713461613,FALSE
+"H3255","Pearson.est","ATPase inhibitor",0.26377,0.702,0.774,7,1,"k.strophanthidin",0.111259039317107,0,FALSE
+"H3255","Pearson.est","Aurora kinase inhibitor",-0.51031,-1.24,0.207,1004,0.776,"barasertib.HQPA, AMG900, aurora.a.inhibitor.i, CCT129202, AT.9283, SNS.314, KW.2449, MK.8745, ENMD.2076, PF.03814735, barasertib, hesperadin, tozasertib",0.684029654543082,0.110138278741812,FALSE
+"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.59929,-1.45,0.086,973,0.609,"azithromycin, azalomycin.b, josamycin, radezolid, tilmicosin, dirithromycin",1.06550154875643,0.215382707367125,FALSE
+"H3255","Pearson.est","bacterial DNA gyrase inhibitor",0.48365,1.31,0.165,170,0.622,"finafloxacin, novobiocin, sarafloxacin",0.782516055786094,0.206209615309181,FALSE
+"H3255","Pearson.est","BCL inhibitor",-0.34925,-0.848,0.644,1135,0.806,"gossypol, ABT.737",0.191114132640188,0.0936649581949093,FALSE
+"H3255","Pearson.est","Bcr.Abl kinase inhibitor",-0.53686,-1.32,0.165,1182,0.748,"nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.782516055786094,0.126098402135539,FALSE
+"H3255","Pearson.est","benzodiazepine receptor agonist",0.21783,0.609,0.938,96,1,"ZK.93423, gamma.aminobutyric.acid",0.0277971616209356,0,FALSE
+"H3255","Pearson.est","bromodomain inhibitor",-0.43252,-1.04,0.412,871,0.765,"JQ1...., PFI.1, I.BET151, bromosporine",0.385102783966865,0.116338564846382,FALSE
+"H3255","Pearson.est","calcium channel blocker",-0.49267,-1.21,0.241,1173,0.73,"cinnarazine, mibefradil, carboxyamidotriazole, SR.33805",0.617982957425132,0.136677139879544,FALSE
+"H3255","Pearson.est","CC chemokine receptor antagonist",-0.36157,-0.878,0.614,1170,0.874,"PF.04136309, navarixin",0.211831628858832,0.058488567365597,FALSE
+"H3255","Pearson.est","CDK inhibitor",-0.28386,-0.689,0.84,900,0.888,"BMS.265246, indisulam, AZD5438, JNJ.7706621, kenpaullone, ribociclib, abemaciclib, NU6027, R547, arcyriaflavin.a, indirubin",0.0757207139381184,0.051587034221399,FALSE
+"H3255","Pearson.est","CHK inhibitor",0.5472,1.52,0.0931,89,0.538,"SCH.900776, CHIR.124, LY2603618",1.03105031901866,0.269217724333611,FALSE
+"H3255","Pearson.est","cyclooxygenase inhibitor",-0.29365,-0.71,0.822,1022,0.882,"aspirin, FK.3311, tepoxalin, piroxicam, metoxibutropate, indoprofen, naproxen, pterostilbene, FR.122047, tryptanthrin",0.0851281824599496,0.0545314148681803,FALSE
+"H3255","Pearson.est","cytochrome P450 inhibitor",-0.25583,-0.61,0.909,1337,0.948,"clotrimazole",0.0414361167780325,0.0231916626619338,FALSE
+"H3255","Pearson.est","DNA alkylating agent",-0.4127,-1.01,0.444,1075,0.754,"temozolomide, cyclophosphamide, carmustine, carboplatin, melphalan, satraplatin, mitomycin.c",0.35261702988538,0.122628654130226,FALSE
+"H3255","Pearson.est","DNA inhibitor",-0.42267,-1.02,0.44,1113,0.757,"pibenzimol, carmustine, carboplatin, metronidazole, melphalan, tirapazamine, mechlorethamine",0.356547323513813,0.120904120499927,FALSE
+"H3255","Pearson.est","DNA methyltransferase inhibitor",0.42506,1.19,0.219,198,0.581,"decitabine, SGI.1027, azacitidine",0.659555885159882,0.235823867609669,FALSE
+"H3255","Pearson.est","DNA polymerase inhibitor",0.34743,0.991,0.4,64,0.667,"cephalomannine",0.397940008672038,0.175874166083451,FALSE
+"H3255","Pearson.est","DNA synthesis inhibitor",-0.3372,-0.836,0.676,972,0.808,"nelarabine, estramustine.phosphate, enocitabine, CB.10.277, altretamine, mitomycin.c",0.170053304058364,0.0925886392254138,FALSE
+"H3255","Pearson.est","dopamine receptor antagonist",-0.40525,-0.979,0.463,1088,0.774,"amisulpride, paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.334419008982047,0.111259039317107,FALSE
+"H3255","Pearson.est","estrogen receptor agonist",0.43425,1.2,0.229,43,0.617,"PPT, levonorgestrel",0.640164517660112,0.209714835966758,FALSE
+"H3255","Pearson.est","estrogen receptor antagonist",-0.76628,-1.88,0.00855,1336,0.202,"toremifene, fulvestrant, danazol",2.06803388527183,0.694648630553376,TRUE
+"H3255","Pearson.est","FGFR inhibitor",-0.63245,-1.54,0.0438,1039,0.593,"orantinib, PD.173074, lenvatinib, MK.2461, lucitanib, erdafitinib",1.3585258894959,0.226945306635737,FALSE
+"H3255","Pearson.est","FLT3 inhibitor",-0.63194,-1.5,0.0722,1084,0.534,"sunitinib, KW.2449, sorafenib, ENMD.2076, midostaurin, GTP.14564, tandutinib, TG.101348, quizartinib, ponatinib, tozasertib",1.14146280243036,0.272458742971444,FALSE
+"H3255","Pearson.est","glucocorticoid receptor agonist",0.43726,1.17,0.274,272,0.566,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, triamcinolone.acetonide, halcinonide, desonide, fluocinolone.acetonide",0.562249437179612,0.247183568811729,FALSE
+"H3255","Pearson.est","glutamate receptor antagonist",0.23694,0.667,0.827,110,1,"SIB.1757, latrepirdine",0.0824944904474534,0,FALSE
+"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.5166,-1.27,0.181,1246,0.851,"GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.742321425130815,0.0700704399154121,FALSE
+"H3255","Pearson.est","growth factor receptor inhibitor",-0.49056,-1.2,0.228,782,0.684,"AZD3463, lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.642065152999546,0.164943898279884,FALSE
+"H3255","Pearson.est","HCV inhibitor",0.38666,1.06,0.375,53,0.587,"daclatasvir",0.425968732272281,0.231361898752386,FALSE
+"H3255","Pearson.est","HDAC inhibitor",-0.4784,-1.17,0.3,1063,0.591,"AR.42, panobinostat, trichostatin.a, givinostat, vorinostat, M.344, RG2833, resminostat, R306465, RGFP966",0.522878745280338,0.228412519118745,FALSE
+"H3255","Pearson.est","histamine receptor antagonist",-0.29622,-0.71,0.834,1142,0.882,"BF2.649, tecastemizole, lafutidine, epinastine",0.0788339493622613,0.0545314148681803,FALSE
+"H3255","Pearson.est","HMGCR inhibitor",-0.64843,-1.56,0.0427,983,0.872,"mevastatin, atorvastatin, lovastatin, fluvastatin",1.36957212497498,0.0594835150674328,FALSE
+"H3255","Pearson.est","HSP inhibitor",0.62413,1.69,0.0356,280,0.574,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, VER.49009, ganetespib",1.44855000202712,0.241088107602027,FALSE
+"H3255","Pearson.est","JAK inhibitor",-0.35901,-0.877,0.632,1067,0.834,"AZD1480, AT.9283, CEP.33779, TG.101348, TG.101209, tozasertib",0.199282921717615,0.0788339493622613,FALSE
+"H3255","Pearson.est","KIT inhibitor",-0.49898,-1.19,0.271,1084,0.646,"sunitinib, sorafenib, imatinib, midostaurin, tandutinib, lenvatinib, KI.8751, masitinib",0.567030709125594,0.189767482004916,FALSE
+"H3255","Pearson.est","MDM inhibitor",-0.36796,-0.913,0.557,1083,0.854,"serdemetan, RITA",0.254144804826271,0.068542129310995,FALSE
+"H3255","Pearson.est","MEK inhibitor",0.6913,1.87,0.027,132,0.506,"trametinib, selumetinib, AS.703026, Ro.4987655, AZD8330, MEK1.2.inhibitor, cobimetinib, TAK.733, PD.0325901, PD.198306",1.56863623584101,0.295849483160201,FALSE
+"H3255","Pearson.est","MET inhibitor",-0.70389,-1.72,0.0157,1413,0.415,"NVP.BVU972, AMG458",1.80410034759077,0.381951903287907,FALSE
+"H3255","Pearson.est","microtubule inhibitor",0.20723,0.582,0.925,1150,1,"triclabendazole, secnidazole, vinflunine, podophyllotoxin, vinblastine, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0338582672609674,0,FALSE
+"H3255","Pearson.est","mTOR inhibitor",-0.3858,-0.927,0.575,969,0.851,"XL388, sirolimus, GSK2126458, LY303511, torin.1, LY3023414, PF.04691502, AZD2014, ku.0063794, WYE.354, SB.2343",0.24033215531037,0.0700704399154121,FALSE
+"H3255","Pearson.est","NFkB pathway inhibitor",-0.21609,-0.526,0.969,762,0.966,"BAY.11.7085, bortezomib, bindarit, curcumin, parthenolide, EVP4593, betulinic.acid",0.0136762229492347,0.0150228735845067,FALSE
+"H3255","Pearson.est","opioid receptor agonist",-0.45999,-1.14,0.301,771,0.628,"BW.180C, ADL5859, salvinorin.a, trimebutine, cebranopadol",0.521433504406157,0.202040356262804,FALSE
+"H3255","Pearson.est","p38 MAPK inhibitor",-0.48778,-1.18,0.253,1157,0.617,"TAK.715, SB.239063, skepinone.l",0.596879478824182,0.209714835966758,FALSE
+"H3255","Pearson.est","PARP inhibitor",-0.58771,-1.44,0.0958,1158,0.57,"AG.14361, niraparib, PJ.34, E7449",1.01863449092146,0.244125144327509,FALSE
+"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.48509,-1.19,0.275,1039,0.646,"orantinib, sunitinib, crenolanib, sorafenib, axitinib, linifanib, imatinib, tandutinib, lenvatinib, ponatinib, KI.8751, masitinib",0.560667306169737,0.189767482004916,FALSE
+"H3255","Pearson.est","phosphatase inhibitor",-0.46127,-1.13,0.302,870,0.626,"AS.1949490, CID.5458317, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., alexidine, GSK2830371, BVT.948",0.519993057042849,0.20342566678957,FALSE
+"H3255","Pearson.est","phosphodiesterase inhibitor",0.19301,0.563,0.951,189,0.99,"cilostamide, EMD.53998",0.0218194830625861,0.00436480540245009,FALSE
+"H3255","Pearson.est","PI3K inhibitor",-0.36507,-0.892,0.59,774,0.871,"voxtalisib, PI.828, TG.100713, PI3K.IN.2, YM.201636, BGT226, pilaralisib, TG100.115, GSK2126458, LY303511, AZD6482, LY3023414, CUDC.907, PF.04691502, GDC.0941, CH5132799, SB.2343",0.229147988357856,0.0599818449923368,FALSE
+"H3255","Pearson.est","PLK inhibitor",0.32933,0.905,0.539,95,0.744,"HMN.214",0.268411234813261,0.128427064454121,FALSE
+"H3255","Pearson.est","potassium channel blocker",-0.35444,-0.87,0.625,1181,0.826,"ibutilide, meglitinide",0.204119982655925,0.0830199526796178,FALSE
+"H3255","Pearson.est","PPAR receptor agonist",-0.35309,-0.858,0.637,1286,0.827,"pterostilbene",0.19586056766465,0.0824944904474534,FALSE
+"H3255","Pearson.est","progesterone receptor agonist",-0.41991,-1.05,0.399,1169,0.769,"dienogest, melengestrol.acetate, danazol",0.399027104313252,0.114073660198569,FALSE
+"H3255","Pearson.est","proteasome inhibitor",0.45494,1.26,0.188,94,0.565,"carfilzomib, MG.132",0.72584215073632,0.247951552180562,FALSE
+"H3255","Pearson.est","protein synthesis inhibitor",0.42804,1.26,0.171,305,0.565,"homoharringtonine, bruceantin, cycloheximide, anguidine, clofoctol, chloramphenicol.palmitate, harringtonine, methacycline, puromycin, emetine",0.767003889607846,0.247951552180562,FALSE
+"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.28681,0.789,0.722,1035,0.913,"AV.412, tyrphostin.A9, CP.724714, PP.121, mubritinib, NVP.TAE226, rheochrysidin, BMS.599626",0.141462802430361,0.039529222465701,FALSE
+"H3255","Pearson.est","RAF inhibitor",0.32205,0.906,0.576,121,0.783,"AZ.628, LGX818, vemurafenib",0.239577516576788,0.106238237942057,FALSE
+"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.32491,-0.793,0.722,1084,0.839,"sunitinib, sorafenib, cabozantinib",0.141462802430361,0.0762380391712997,FALSE
+"H3255","Pearson.est","retinoid receptor agonist",-0.52257,-1.26,0.2,1247,0.822,"fenretinide, adapalene, bexarotene",0.698970004336019,0.0851281824599496,FALSE
+"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.33086,-0.809,0.686,845,0.832,"cytarabine, hydroxyurea, clofarabine, fludarabine, cladribine, pentostatin",0.163675884293248,0.0798766737092761,FALSE
+"H3255","Pearson.est","serotonin receptor agonist",-0.57527,-1.38,0.122,1117,0.684,"NAN.190, ipsapirone, aripiprazole",0.913640169325252,0.164943898279884,FALSE
+"H3255","Pearson.est","serotonin receptor antagonist",-0.49694,-1.22,0.236,1323,0.788,"lurasidone, aripiprazole",0.627087997029893,0.103473782510445,FALSE
+"H3255","Pearson.est","sodium channel blocker",-0.40308,-0.984,0.473,960,0.785,"cibenzoline, A.803467, ajmaline, oxcarbazepine, triamterene, quinidine, lappaconite",0.325138859262188,0.105130343254747,FALSE
+"H3255","Pearson.est","src inhibitor",-0.34356,-0.85,0.654,1146,0.821,"KX2.391, PP.1, masitinib",0.184422251675733,0.0856568428805592,FALSE
+"H3255","Pearson.est","sterol demethylase inhibitor",-0.49964,-1.21,0.23,1159,0.73,"terconazole, ketoconazole",0.638272163982407,0.136677139879544,FALSE
+"H3255","Pearson.est","TGF beta receptor inhibitor",0.41881,1.15,0.264,104,0.514,"repsox, SB.525334",0.578396073130169,0.289036881004724,FALSE
+"H3255","Pearson.est","thymidylate synthase inhibitor",0.52417,1.47,0.122,319,0.512,"capecitabine, doxifluridine, ftorafur, carmofur",0.913640169325252,0.290730039024169,FALSE
+"H3255","Pearson.est","topoisomerase inhibitor",-0.21691,-0.532,0.967,859,0.981,"camptothecin, voreloxin, topotecan, nemorubicin, SN.38, etoposide.phosphate, TAS.103, rubitecan, genz.644282, dexrazoxane, fleroxacin, irinotecan",0.0145735259169983,0.0083309926200515,FALSE
+"H3255","Pearson.est","tubulin polymerization inhibitor",0.4244,1.15,0.256,367,0.514,"mebendazole, paclitaxel, CYT.997, BNC105, vindesine, vincristine, epothilone.b, taltobulin, oxibendazole, dolastatin.10, vinorelbine, podophyllotoxin, fenbendazole, fosbretabulin",0.59176003468815,0.289036881004724,FALSE
+"H3255","Pearson.est","tyrosine kinase inhibitor",0.16647,0.468,0.993,175,0.991,"vandetanib, dasatinib, hypericin, AV.412",0.00305075150461883,0.00392634551472468,FALSE
+"H3255","Pearson.est","VEGFR inhibitor",-0.29843,-0.74,0.796,1084,0.878,"sunitinib, sorafenib, cabozantinib, axitinib, PD.173074, linifanib, ENMD.2076, lenvatinib, MK.2461, lucitanib, tivozanib, MGCD.265, KI.8751",0.0990869322623309,0.0565054840938974,FALSE
+"H3255","Pearson.est","vitamin D receptor agonist",-0.49027,-1.2,0.234,1111,0.684,"maxacalcitol, paricalcitol, tacalcitol",0.630784142589857,0.164943898279884,FALSE
+"H1648","Pearson.est","EGFR inhibitor",0.40956,1.19,0.243,186,0.815,"pelitinib, canertinib, brigatinib, vandetanib, XL.647, BMS.690514, afatinib, erlotinib, rociletinib, CUDC.101, dacomitinib, AZD8931, neratinib, PD.168393, lapatinib",0.614393726401688,0.0888423912600234,FALSE
+"H1648","Pearson.est","Abl kinase inhibitor",-0.52206,-1.27,0.196,1158,0.67,"KW.2449, nilotinib, imatinib, flumatinib, ponatinib, tozasertib",0.707743928643524,0.173925197299174,FALSE
+"H1648","Pearson.est","acetylcholine receptor agonist",-0.40693,-0.987,0.483,1064,0.751,"nicotine, nefiracetam, pilocarpine",0.316052869248488,0.124360062995832,FALSE
+"H1648","Pearson.est","acetylcholine receptor antagonist",-0.47575,-1.16,0.291,1056,0.643,"dicycloverine, iododexetimide, methscopolamine",0.536107011014093,0.191789027075778,FALSE
+"H1648","Pearson.est","adenosine receptor antagonist",-0.57482,-1.38,0.13,1027,0.598,"CGS.15943, istradefylline, MRS.1220, SCH.58261",0.886056647693163,0.223298816011589,FALSE
+"H1648","Pearson.est","adrenergic receptor agonist",-0.48498,-1.17,0.279,1099,0.647,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.554395796726402,0.1890957193313,FALSE
+"H1648","Pearson.est","adrenergic receptor antagonist",0.38544,1.1,0.321,230,0.866,"prazosin, vincamine, RS.17053, practolol, levobunolol, dihydroergocristine, idazoxan",0.493494967595128,0.0624821079826534,FALSE
+"H1648","Pearson.est","AKT inhibitor",-0.40502,-0.974,0.503,1095,0.755,"ONC201, uprosertib, A.674563, CCT128930",0.298432014944073,0.122053048370812,FALSE
+"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.2471,0.686,0.841,143,1,"brigatinib, GW.788388, lorlatinib",0.0752040042020878,0,FALSE
+"H1648","Pearson.est","androgen receptor antagonist",-0.61496,-1.48,0.0595,1032,0.774,"nilutamide, flutamide, bicalutamide",1.22548303427145,0.111259039317107,FALSE
+"H1648","Pearson.est","antioxidant",-0.49244,-1.19,0.251,1323,0.63,"benfotiamine, trolox",0.600326278518962,0.200659450546418,FALSE
+"H1648","Pearson.est","AP inhibitor",0.54387,1.5,0.0897,50,0.58,"GDC.0152, birinapant",1.04720755695591,0.236572006437063,FALSE
+"H1648","Pearson.est","ATPase inhibitor",0.26585,0.744,0.781,198,1,"k.strophanthidin, digitoxin, ouabain",0.1073489661227,0,FALSE
+"H1648","Pearson.est","Aurora kinase inhibitor",-0.58096,-1.42,0.104,1077,0.671,"barasertib.HQPA, AMG900, CCT129202, aurora.a.inhibitor.i, AT.9283, KW.2449, SNS.314, ENMD.2076, PF.03814735, MK.8745, barasertib, hesperadin, tozasertib",0.98296666070122,0.173277479831008,FALSE
+"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.49843,-1.21,0.237,848,0.71,"azithromycin, azalomycin.b, tilmicosin, josamycin, radezolid, dirithromycin",0.625251653989896,0.148741651280925,FALSE
+"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.41798,1.16,0.304,218,0.8,"novobiocin, finafloxacin, sarafloxacin",0.517126416391246,0.0969100130080564,FALSE
+"H1648","Pearson.est","BCL inhibitor",-0.39412,-0.957,0.516,1129,0.746,"gossypol, ABT.737",0.287350298372789,0.127261172527331,FALSE
+"H1648","Pearson.est","Bcr.Abl kinase inhibitor",-0.51987,-1.26,0.201,1176,0.62,"nilotinib, imatinib, flumatinib, ponatinib, tozasertib",0.696803942579511,0.207608310501746,FALSE
+"H1648","Pearson.est","benzodiazepine receptor agonist",0.18389,0.523,0.979,171,1,"ZK.93423, gamma.aminobutyric.acid, eprinomectin",0.00921730819686218,0,FALSE
+"H1648","Pearson.est","bromodomain inhibitor",-0.58773,-1.42,0.0857,1050,0.671,"JQ1...., PFI.1, I.BET151, bromosporine",1.0670191780768,0.173277479831008,FALSE
+"H1648","Pearson.est","calcium channel blocker",-0.56673,-1.39,0.109,1205,0.625,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.962573502059376,0.204119982655925,FALSE
+"H1648","Pearson.est","CC chemokine receptor antagonist",-0.45353,-1.1,0.345,817,0.676,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.462180904926726,0.170053304058364,FALSE
+"H1648","Pearson.est","CDK inhibitor",-0.34089,-0.816,0.709,978,0.831,"AZD5438, BMS.265246, abemaciclib, ribociclib, JNJ.7706621, NU6027, kenpaullone, R547, indirubin, arcyriaflavin.a",0.149353764816933,0.080398976215889,FALSE
+"H1648","Pearson.est","CHK inhibitor",0.55562,1.59,0.0598,83,0.557,"SCH.900776, CHIR.124, LY2603618",1.22329881601159,0.254144804826271,FALSE
+"H1648","Pearson.est","cyclooxygenase inhibitor",-0.3438,-0.844,0.648,1089,0.884,"FK.3311, tepoxalin, indoprofen, piroxicam, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.188424994129407,0.0535477349869269,FALSE
+"H1648","Pearson.est","cytochrome P450 inhibitor",-0.20945,-0.514,0.971,1039,0.972,"cobicistat, clotrimazole",0.0127807700919951,0.0123337350737254,FALSE
+"H1648","Pearson.est","DNA alkylating agent",-0.40385,-0.963,0.52,1036,0.755,"temozolomide, carmustine, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.283996656365201,0.122053048370812,FALSE
+"H1648","Pearson.est","DNA inhibitor",-0.42145,-1.02,0.45,1055,0.729,"carmustine, carboplatin, pibenzimol, melphalan, metronidazole, primaquine, tirapazamine, mechlorethamine",0.346787486224656,0.137272471682025,FALSE
+"H1648","Pearson.est","DNA methyltransferase inhibitor",0.36269,1.06,0.369,214,0.811,"decitabine, SGI.1027, azacitidine",0.43297363384094,0.090979145788844,FALSE
+"H1648","Pearson.est","DNA polymerase inhibitor",0.35556,0.974,0.462,936,0.881,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, trifluridine, foscarnet, cidofovir",0.335358024443874,0.0550240915879521,FALSE
+"H1648","Pearson.est","DNA synthesis inhibitor",-0.32137,-0.771,0.756,783,0.859,"cisplatin, nelarabine, azodicarbonamide, artesunate, estramustine.phosphate, altretamine, enocitabine, CB.10.277, mitomycin.c",0.121478204498793,0.0660068361687577,FALSE
+"H1648","Pearson.est","dopamine receptor antagonist",-0.40927,-1,0.465,1131,0.747,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.332547047110046,0.126679398184601,FALSE
+"H1648","Pearson.est","estrogen receptor agonist",0.43086,1.23,0.206,40,0.958,"PPT, levonorgestrel",0.686132779630847,0.0186344909214556,FALSE
+"H1648","Pearson.est","estrogen receptor antagonist",-0.71319,-1.73,0.012,1262,0.669,"toremifene, danazol, fulvestrant",1.92081875395238,0.174573882232177,FALSE
+"H1648","Pearson.est","FGFR inhibitor",-0.63062,-1.55,0.048,985,0.838,"orantinib, PD.173074, lenvatinib, MK.2461, erdafitinib, lucitanib",1.31875876262441,0.0767559813697235,FALSE
+"H1648","Pearson.est","FLT3 inhibitor",-0.56447,-1.37,0.121,1098,0.572,"midostaurin, sorafenib, KW.2449, ENMD.2076, tandutinib, TG.101348, ponatinib, GTP.14564, quizartinib, tozasertib",0.91721462968355,0.242603971206976,FALSE
+"H1648","Pearson.est","glucocorticoid receptor agonist",0.37849,1.08,0.343,284,0.834,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, halcinonide, prednisolone, fluocinolone.acetonide, triamcinolone.acetonide, desonide",0.464705879957229,0.0788339493622613,FALSE
+"H1648","Pearson.est","glutamate receptor antagonist",-0.23727,-0.574,0.939,1259,0.976,"MTPG, IEM1754",0.0273344077338891,0.0105501823333082,FALSE
+"H1648","Pearson.est","glycogen synthase kinase inhibitor",-0.53439,-1.3,0.174,1169,0.672,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, CHIR.98014, indirubin",0.7594507517174,0.172630726946175,FALSE
+"H1648","Pearson.est","growth factor receptor inhibitor",-0.48657,-1.2,0.237,896,0.7,"lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.625251653989896,0.154901959985743,FALSE
+"H1648","Pearson.est","HCV inhibitor",0.29376,0.835,0.656,82,0.962,"daclatasvir",0.18309616062434,0.0168249279621871,FALSE
+"H1648","Pearson.est","HDAC inhibitor",-0.5183,-1.26,0.206,1109,0.62,"dacinostat, AR.42, panobinostat, vorinostat, givinostat, trichostatin.a, RG2833, M.344, resminostat, R306465, RGFP966",0.686132779630847,0.207608310501746,FALSE
+"H1648","Pearson.est","histamine receptor antagonist",-0.33658,-0.833,0.673,1078,0.881,"cyproheptadine, BF2.649, tecastemizole, lafutidine, epinastine",0.171984935776023,0.0550240915879521,FALSE
+"H1648","Pearson.est","HMGCR inhibitor",-0.48895,-1.19,0.263,1238,0.63,"fluvastatin, lovastatin",0.580044251510242,0.200659450546418,FALSE
+"H1648","Pearson.est","HSP inhibitor",0.57715,1.63,0.0622,245,0.715,"BIIB021, KW.2478, SNX.5422, alvespimycin, SNX.2112, NVP.AUY922, ganetespib, VER.49009",1.20620961530918,0.145693958198919,FALSE
+"H1648","Pearson.est","JAK inhibitor",-0.32192,-0.783,0.741,1157,0.861,"AT.9283, AZD1480, TG.101348, TG.101209, tozasertib",0.130181792020672,0.0649968485463452,FALSE
+"H1648","Pearson.est","KIT inhibitor",-0.44088,-1.08,0.358,1098,0.653,"midostaurin, sorafenib, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.446116973356126,0.185086818724926,FALSE
+"H1648","Pearson.est","MDM inhibitor",-0.44831,-1.1,0.37,1101,0.676,"serdemetan, RITA",0.431798275933005,0.170053304058364,FALSE
+"H1648","Pearson.est","MEK inhibitor",0.66901,1.89,0.00833,178,0.475,"selumetinib, trametinib, AS.703026, Ro.4987655, cobimetinib, MEK1.2.inhibitor, AZD8330, TAK.733, PD.198306, PD.0325901",2.07935499859321,0.323306390375133,FALSE
+"H1648","Pearson.est","MET inhibitor",-0.70283,-1.72,0.0211,1416,0.362,"NVP.BVU972, AMG458",1.67571754470231,0.441291429466834,FALSE
+"H1648","Pearson.est","microtubule inhibitor",0.1669,0.486,0.988,1208,0.987,"secnidazole, triclabendazole, vinflunine, podophyllotoxin, vinblastine, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.00524305541237188,0.00568284733036327,FALSE
+"H1648","Pearson.est","mTOR inhibitor",-0.37835,-0.919,0.565,1006,0.793,"LY303511, sirolimus, GSK2126458, XL388, torin.1, PF.04691502, LY3023414, ku.0063794, AZD2014, WYE.354, SB.2343",0.247951552180562,0.100726812682396,FALSE
+"H1648","Pearson.est","NFkB pathway inhibitor",-0.27686,-0.669,0.85,883,0.914,"parthenolide, bindarit, curcumin, EVP4593, betulinic.acid",0.0705810742857073,0.0390538042661686,FALSE
+"H1648","Pearson.est","opioid receptor agonist",-0.47589,-1.15,0.297,851,0.64,"ADL5859, trimebutine, salvinorin.a, cebranopadol",0.527243550682788,0.193820026016113,FALSE
+"H1648","Pearson.est","p38 MAPK inhibitor",-0.48859,-1.19,0.273,975,0.63,"TAK.715, SB.242235, SB.239063, skepinone.l",0.563837352959244,0.200659450546418,FALSE
+"H1648","Pearson.est","PARP inhibitor",-0.59979,-1.47,0.0729,1191,0.683,"AG.14361, niraparib, E7449, PJ.34",1.13727247168203,0.165579296318467,FALSE
+"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45248,-1.08,0.365,985,0.653,"orantinib, sunitinib, crenolanib, sorafenib, axitinib, linifanib, imatinib, tandutinib, lenvatinib, ponatinib, KI.8751, masitinib",0.437707135543525,0.185086818724926,FALSE
+"H1648","Pearson.est","phosphatase inhibitor",-0.4488,-1.09,0.341,824,0.676,"AS.1949490, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, CID.5458317, BVT.948, alexidine, GSK2830371",0.467245621007502,0.170053304058364,FALSE
+"H1648","Pearson.est","phosphodiesterase inhibitor",0.25243,0.713,0.829,1085,1,"cilostamide, EMD.53998, enoximone, anagrelide, avanafil, trequinsin, papaverine, zardaverine, GSK256066, YM.976",0.0814454694497265,0,FALSE
+"H1648","Pearson.est","PI3K inhibitor",-0.34208,-0.831,0.665,724,0.845,"NVP.BEZ235, voxtalisib, pilaralisib, PI3K.IN.2, YM.201636, TG100.115, PKI.179, BGT226, TG.100713, LY303511, GSK2126458, AZD6482, PF.04691502, LY3023414, GDC.0941, CUDC.907, CH5132799, SB.2343",0.177178354696895,0.0731432910503077,FALSE
+"H1648","Pearson.est","PLK inhibitor",0.22137,0.636,0.911,1129,1,"HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0404816230270017,0,FALSE
+"H1648","Pearson.est","potassium channel blocker",0.20742,0.594,0.925,304,1,"dofetilide, mepivacaine, oleoylethanolamide",0.0338582672609674,0,FALSE
+"H1648","Pearson.est","PPAR receptor agonist",-0.33588,-0.82,0.674,1277,0.843,"pterostilbene",0.17134010346468,0.0741724253752577,FALSE
+"H1648","Pearson.est","progesterone receptor agonist",-0.35992,-0.874,0.645,1318,0.852,"melengestrol.acetate, danazol",0.190440285364732,0.0695604052332999,FALSE
+"H1648","Pearson.est","proteasome inhibitor",0.41601,1.22,0.212,92,0.849,"MG.132, carfilzomib",0.673664139071249,0.0710923097560473,FALSE
+"H1648","Pearson.est","protein synthesis inhibitor",0.32281,0.911,0.534,279,0.904,"clofoctol, homoharringtonine, cycloheximide, anguidine, bruceantin, chloramphenicol.palmitate, methacycline, harringtonine, puromycin",0.272458742971444,0.0438315695246367,FALSE
+"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.30155,-0.731,0.783,705,0.895,"rheochrysidin, CP.724714, PP.121, NVP.TAE226, mubritinib, BMS.599626",0.106238237942057,0.048176964684088,FALSE
+"H1648","Pearson.est","RAF inhibitor",0.30484,0.859,0.593,90,0.964,"AZ.628, vemurafenib, LGX818",0.226945306635737,0.0159229660971692,FALSE
+"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.3202,0.95,0.51,24,0.875,"vandetanib",0.292429823902064,0.0579919469776868,FALSE
+"H1648","Pearson.est","retinoid receptor agonist",-0.45689,-1.13,0.307,1210,0.66,"fenretinide, adapalene, bexarotene",0.512861624522813,0.180456064458131,FALSE
+"H1648","Pearson.est","ribonucleotide reductase inhibitor",-0.28703,-0.685,0.858,777,0.915,"clofarabine, hydroxyurea, cytarabine, fludarabine, cladribine, pentostatin",0.0665127121512946,0.0385789059335517,FALSE
+"H1648","Pearson.est","serotonin receptor agonist",-0.61357,-1.48,0.0746,1012,0.774,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",1.12726117252733,0.111259039317107,FALSE
+"H1648","Pearson.est","serotonin receptor antagonist",-0.52947,-1.31,0.181,1370,0.694,"lurasidone, aripiprazole",0.742321425130815,0.158640529545145,FALSE
+"H1648","Pearson.est","sodium channel blocker",-0.42555,-1.02,0.441,1049,0.729,"oxcarbazepine, A.803467, triamterene, ajmaline, quinidine, lappaconite",0.355561410532161,0.137272471682025,FALSE
+"H1648","Pearson.est","src inhibitor",0.36599,1.04,0.407,18,0.792,"dasatinib, saracatinib",0.39040559077478,0.101274818410506,FALSE
+"H1648","Pearson.est","sterol demethylase inhibitor",-0.57205,-1.4,0.0997,1184,0.664,"terconazole, ketoconazole",1.00130484168834,0.177831920631982,FALSE
+"H1648","Pearson.est","TGF beta receptor inhibitor",-0.34196,-0.831,0.711,1387,0.845,"adaprev",0.148130399270234,0.0731432910503077,FALSE
+"H1648","Pearson.est","thymidylate synthase inhibitor",0.50783,1.47,0.112,276,0.52,"capecitabine, doxifluridine, ftorafur, carmofur",0.950781977329818,0.283996656365201,FALSE
+"H1648","Pearson.est","topoisomerase inhibitor",-0.21768,-0.523,0.975,834,0.986,"nemorubicin, camptothecin, valrubicin, voreloxin, etoposide.phosphate, rubitecan, SN.38, TAS.103, genz.644282, fleroxacin, dexrazoxane, irinotecan",0.0109953843014632,0.0061230850587888,FALSE
+"H1648","Pearson.est","tubulin polymerization inhibitor",0.29075,0.831,0.611,388,0.92,"mebendazole, paclitaxel, BNC105, CYT.997, vincristine, vindesine, epothilone.b, oxibendazole, taltobulin, verubulin, vinorelbine, dolastatin.10, fosbretabulin, podophyllotoxin",0.213958789757446,0.0362121726544447,FALSE
+"H1648","Pearson.est","tyrosine kinase inhibitor",0.18939,0.554,0.978,24,1,"dasatinib, vandetanib",0.00966114521239857,0,FALSE
+"H1648","Pearson.est","VEGFR inhibitor",-0.29167,-0.711,0.813,931,0.902,"telatinib, RAF265, orantinib, sunitinib, cabozantinib, PD.173074, sorafenib, axitinib, linifanib, ENMD.2076, lenvatinib, MK.2461, lucitanib, tivozanib, MGCD.265, KI.8751",0.0899094544059319,0.0447934624580583,FALSE
+"H1648","Pearson.est","vitamin D receptor agonist",-0.52263,-1.29,0.179,1199,0.655,"maxacalcitol, tacalcitol, paricalcitol",0.747146969020107,0.183758700008217,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.45153,1.29,0.158,154,0.732,"pelitinib, canertinib, vandetanib, BMS.690514, afatinib, XL.647, rociletinib, erlotinib, brigatinib, dacomitinib, AZD8931, lapatinib, neratinib, poziotinib, CUDC.101",0.801342913045577,0.135488918941608,FALSE
+"H1975","Pearson.est","Abl kinase inhibitor",-0.59683,-1.46,0.0846,1103,1,"metatinib, flumatinib, nilotinib, KW.2449, imatinib, ponatinib, tozasertib",1.07262963696098,0,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",-0.4732,-1.15,0.306,1168,0.613,"nicotine, nefiracetam, pilocarpine",0.51427857351842,0.212539525481585,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",-0.54511,-1.32,0.144,1020,0.602,"dicycloverine, iododexetimide, methscopolamine",0.84163750790475,0.220403508742175,FALSE
+"H1975","Pearson.est","adenosine receptor antagonist",-0.47511,-1.14,0.328,812,0.613,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.484126156288321,0.212539525481585,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",-0.47212,-1.15,0.307,1118,0.613,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.512861624522813,0.212539525481585,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.43364,1.24,0.208,247,0.642,"prazosin, vincamine, RS.17053, practolol, imiloxan, dihydroergocristine, atenolol...., levobunolol, idazoxan",0.681936665037238,0.192464971931147,FALSE
+"H1975","Pearson.est","AKT inhibitor",-0.44939,-1.09,0.368,1018,0.694,"triciribine, uprosertib, ONC201, A.674563, CCT128930",0.434152181326482,0.158640529545145,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33814,-0.825,0.697,1263,0.845,"alectinib, AP26113, DMH1",0.156767221901991,0.0731432910503077,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",-0.59789,-1.45,0.0876,1005,0.697,"nilutamide, flutamide, bicalutamide",1.05749589383192,0.156767221901991,FALSE
+"H1975","Pearson.est","antioxidant",-0.53452,-1.3,0.18,1358,0.579,"benfotiamine, trolox",0.744727494896694,0.237321436272564,FALSE
+"H1975","Pearson.est","AP inhibitor",0.58908,1.65,0.0595,46,0.633,"birinapant, GDC.0152",1.22548303427145,0.198596289982645,FALSE
+"H1975","Pearson.est","ATPase inhibitor",0.266,0.739,0.783,3,1,"k.strophanthidin",0.106238237942057,0,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",-0.5926,-1.45,0.0772,1105,0.697,"barasertib.HQPA, aurora.a.inhibitor.i, CCT129202, AMG900, ENMD.2076, SNS.314, KW.2449, AT.9283, MK.8745, PF.03814735, barasertib, hesperadin, tozasertib",1.11238269966426,0.156767221901991,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.5205,-1.28,0.18,796,0.595,"azithromycin, valnemulin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.744727494896694,0.22548303427145,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",0.53795,1.49,0.103,152,0.447,"finafloxacin, sarafloxacin, novobiocin",0.987162775294828,0.349692476868064,FALSE
+"H1975","Pearson.est","BCL inhibitor",-0.44202,-1.07,0.378,1111,0.671,"gossypol, ABT.737",0.422508200162775,0.173277479831008,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.58512,-1.44,0.103,1103,0.573,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.987162775294828,0.24184537803261,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.26308,0.738,0.751,47,0.97,"ZK.93423, gamma.aminobutyric.acid",0.124360062995832,0.0132282657337552,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",-0.48436,-1.19,0.248,961,0.599,"JQ1...., PFI.1, I.BET151, bromosporine",0.605548319173784,0.222573177610689,FALSE
+"H1975","Pearson.est","calcium channel blocker",-0.51556,-1.23,0.219,1157,0.591,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.659555885159882,0.228412519118745,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",-0.3502,-0.843,0.666,634,0.854,"UNBS.5162, RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.176525770829699,0.068542129310995,FALSE
+"H1975","Pearson.est","CDK inhibitor",-0.39343,-0.953,0.511,939,0.776,"palbociclib, indisulam, BMS.265246, AZD5438, JNJ.7706621, NU6027, kenpaullone, ribociclib, abemaciclib, indirubin, R547, arcyriaflavin.a",0.291579099865287,0.110138278741812,FALSE
+"H1975","Pearson.est","CHK inhibitor",0.53401,1.49,0.0842,121,0.447,"SCH.900776, CHIR.124, LY2603618",1.07468790850035,0.349692476868064,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.3051,-0.74,0.812,1006,0.862,"metoxibutropate, piroxicam, FK.3311, indoprofen, tepoxalin, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.0904439707588247,0.0644927341752872,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",0.24741,0.718,0.791,166,0.957,"PF.4981517, morin",0.101823516502323,0.0190880622231565,FALSE
+"H1975","Pearson.est","DNA alkylating agent",-0.41597,-1.03,0.439,926,0.709,"streptozotocin, ifosfamide, carmustine, temozolomide, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.357535479757879,0.149353764816933,FALSE
+"H1975","Pearson.est","DNA inhibitor",-0.41781,-1.01,0.448,1019,0.708,"carmustine, carboplatin, primaquine, pibenzimol, metronidazole, tirapazamine, melphalan, mechlorethamine",0.348721986001856,0.149966742310231,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.32672,0.909,0.5,242,0.894,"decitabine, SGI.1027, azacitidine",0.301029995663981,0.0486624812040823,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",0.31458,0.869,0.613,995,0.924,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.212539525481585,0.0343280287798933,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",-0.32748,-0.786,0.741,773,0.85,"nelarabine, cisplatin, artesunate, azodicarbonamide, estramustine.phosphate, CB.10.277, enocitabine, altretamine, mitomycin.c",0.130181792020672,0.0705810742857073,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",-0.39325,-0.963,0.505,950,0.777,"raclopride, amisulpride, UH.232...., paliperidone, nemonapride, lurasidone, mesoridazine",0.296708621881339,0.109578981199086,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",0.45122,1.22,0.231,37,0.549,"levonorgestrel, PPT",0.636388020107856,0.260427655549908,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",-0.74758,-1.79,0.00951,1290,0.45,"toremifene, fulvestrant, danazol",2.02181948306259,0.346787486224656,FALSE
+"H1975","Pearson.est","FGFR inhibitor",-0.5862,-1.43,0.0995,1145,0.49,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",1.00217691925427,0.309803919971486,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",-0.61733,-1.48,0.069,1112,1,"sunitinib, midostaurin, ENMD.2076, tandutinib, KW.2449, sorafenib, GTP.14564, TG.101348, quizartinib, ponatinib, tozasertib",1.16115090926274,0,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",0.43796,1.23,0.224,294,0.592,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, triamcinolone.acetonide, ciclesonide, halcinonide, prednisolone, fluocinolone.acetonide, desonide, fludroxycortide",0.649751981665837,0.22767829327708,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",0.26673,0.75,0.754,165,1,"SIB.1757, latrepirdine, kynurenic.acid",0.122628654130226,0,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.48809,-1.19,0.268,1123,0.599,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.571865205971211,0.222573177610689,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",-0.55162,-1.33,0.133,872,0.615,"lestaurtinib, GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.876148359032914,0.211124884224583,FALSE
+"H1975","Pearson.est","HCV inhibitor",0.36415,1.02,0.402,52,0.842,"daclatasvir",0.39577394691553,0.0746879085003505,FALSE
+"H1975","Pearson.est","HDAC inhibitor",-0.49198,-1.21,0.245,1270,0.607,"trichostatin.a, givinostat, vorinostat, M.344, R306465, RG2833, resminostat, RGFP966",0.610833915635468,0.216811308924742,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",-0.34126,-0.826,0.675,1170,0.861,"tecastemizole, lafutidine, BF2.649, epinastine",0.170696227168975,0.0649968485463452,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.56358,-1.38,0.107,1281,0.571,"lovastatin, fluvastatin",0.97061622231479,0.243363891754152,FALSE
+"H1975","Pearson.est","HSP inhibitor",0.57273,1.56,0.0717,304,0.572,"BIIB021, KW.2478, SNX.5422, alvespimycin, SNX.2112, NVP.AUY922, VER.49009, ganetespib",1.1444808443322,0.242603971206976,FALSE
+"H1975","Pearson.est","JAK inhibitor",-0.3292,-0.815,0.685,872,0.824,"lestaurtinib, pacritinib, LY2784544, AZD1480, CEP.33779, AT.9283, TG.101348, TG.101209, tozasertib",0.164309428507574,0.0840727883028842,FALSE
+"H1975","Pearson.est","KIT inhibitor",-0.51244,-1.24,0.219,1112,0.597,"sunitinib, midostaurin, tandutinib, sorafenib, imatinib, lenvatinib, KI.8751, masitinib",0.659555885159882,0.224025668870631,FALSE
+"H1975","Pearson.est","MDM inhibitor",-0.42641,-1.02,0.439,1120,0.707,"serdemetan, RITA",0.357535479757879,0.150580586203101,FALSE
+"H1975","Pearson.est","MEK inhibitor",0.66027,1.83,0.0412,158,0.6,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, AZD8330, TAK.733, cobimetinib, PD.198306, PD.0325901",1.38510278396687,0.221848749616356,FALSE
+"H1975","Pearson.est","MET inhibitor",-0.67436,-1.65,0.0275,1403,0.719,"NVP.BVU972, AMG458",1.56066730616974,0.143271109617117,FALSE
+"H1975","Pearson.est","microtubule inhibitor",-0.13971,-0.337,1,766,1,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0,0,FALSE
+"H1975","Pearson.est","mTOR inhibitor",-0.38761,-0.944,0.529,722,0.772,"deforolimus, NVP.BEZ235, voxtalisib, temsirolimus, PKI.179, OSI.027, torin.2, MLN0128, sirolimus, LY303511, XL388, GSK2126458, torin.1, PF.04691502, LY3023414, ku.0063794, AZD2014, WYE.354, SB.2343",0.276544327964814,0.112382699664264,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",-0.2749,-0.665,0.859,819,0.914,"parthenolide, curcumin, bortezomib, bindarit, EVP4593, betulinic.acid",0.0660068361687577,0.0390538042661686,FALSE
+"H1975","Pearson.est","opioid receptor agonist",-0.44164,-1.07,0.383,798,0.671,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.416801226031377,0.173277479831008,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",-0.43447,-1.06,0.397,1300,0.672,"SB.239063, skepinone.l",0.401209493236885,0.172630726946175,FALSE
+"H1975","Pearson.est","PARP inhibitor",-0.6051,-1.45,0.0755,1160,0.697,"AG.14361, PJ.34, niraparib, E7449",1.12205304837081,0.156767221901991,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.51173,-1.27,0.19,1112,0.556,"sunitinib, linifanib, crenolanib, axitinib, tandutinib, sorafenib, imatinib, lenvatinib, ponatinib, KI.8751, masitinib",0.721246399047171,0.254925208417942,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",-0.52899,-1.3,0.173,913,0.579,"AS.1949490, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, BVT.948, GSK2830371",0.761953896871205,0.237321436272564,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",0.25191,0.717,0.778,155,0.915,"cilostamide, EMD.53998",0.109020403010311,0.0385789059335517,FALSE
+"H1975","Pearson.est","PI3K inhibitor",-0.37949,-0.922,0.557,740,0.794,"pilaralisib, NVP.BEZ235, voxtalisib, YM.201636, PKI.179, PI3K.IN.2, TG100.115, TG.100713, BGT226, LY303511, AZD6482, GSK2126458, PF.04691502, LY3023414, GDC.0941, CUDC.907, CH5132799, SB.2343",0.254144804826271,0.100179497572904,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.24844,0.704,0.833,1090,0.893,"HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0793549985932124,0.0491485411114536,FALSE
+"H1975","Pearson.est","potassium channel blocker",0.23757,0.663,0.878,303,0.869,"dofetilide, mepivacaine, oleoylethanolamide",0.0565054840938974,0.0609802235513335,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",-0.31787,-0.78,0.743,1255,0.842,"pterostilbene",0.129011186239425,0.0746879085003505,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.37393,-0.916,0.569,1151,0.767,"dienogest, melengestrol.acetate, danazol",0.244887733604929,0.115204636051019,FALSE
+"H1975","Pearson.est","proteasome inhibitor",0.4225,1.18,0.274,104,0.569,"carfilzomib, MG.132",0.562249437179612,0.244887733604929,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.34789,0.963,0.471,147,0.902,"homoharringtonine, bruceantin, cycloheximide, clofoctol, chloramphenicol.palmitate, anguidine",0.326979092871104,0.0447934624580583,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",-0.24162,-0.585,0.935,947,0.968,"NVP.TAE226, mubritinib, BMS.599626",0.0291883891274822,0.0141246426916063,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.28963,0.824,0.663,90,0.969,"AZ.628, LGX818, vemurafenib",0.178486471595227,0.0136762229492347,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",-0.35619,-0.868,0.635,1112,0.832,"sunitinib, cabozantinib, sorafenib",0.197226274708024,0.0798766737092761,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",-0.56103,-1.36,0.101,1283,0.581,"fenretinide, adapalene, bexarotene",0.995678626217357,0.235823867609669,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.31425,-0.761,0.754,780,0.851,"cytarabine, hydroxyurea, clofarabine, fludarabine, cladribine, pentostatin",0.122628654130226,0.0700704399154121,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.59748,-1.43,0.108,975,0.49,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",0.96657624451305,0.309803919971486,FALSE
+"H1975","Pearson.est","serotonin receptor antagonist",-0.48294,-1.15,0.302,1331,0.613,"lurasidone, aripiprazole",0.519993057042849,0.212539525481585,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.4458,-1.08,0.36,1002,0.692,"oxcarbazepine, A.803467, cibenzoline, triamterene, ajmaline, quinidine, lappaconite",0.443697499232713,0.159893905543242,FALSE
+"H1975","Pearson.est","src inhibitor",-0.38744,-0.921,0.561,1203,0.777,"PP.1, KX2.391, masitinib",0.251037138743839,0.109578981199086,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",-0.59575,-1.44,0.0976,1153,0.573,"terconazole, ketoconazole",1.01055018233331,0.24184537803261,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.33732,0.932,0.504,271,0.906,"repsox, SB.525334, LY2109761",0.297569463554475,0.0428718023231869,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.46176,1.28,0.153,217,0.649,"capecitabine, doxifluridine, ftorafur",0.815308569182401,0.187755303199631,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",-0.30055,-0.733,0.794,859,0.854,"valrubicin, topotecan, etoposide.phosphate, voreloxin, nemorubicin, camptothecin, SN.38, rubitecan, genz.644282, TAS.103, fleroxacin, dexrazoxane, irinotecan",0.100179497572904,0.068542129310995,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",0.24947,0.682,0.829,404,0.882,"mebendazole, CYT.997, paclitaxel, BNC105, vincristine, vindesine, taltobulin, epothilone.b, oxibendazole, vinorelbine, fenbendazole, dolastatin.10, podophyllotoxin, verubulin",0.0814454694497265,0.0545314148681803,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",-0.20373,-0.492,0.98,1112,0.998,"sunitinib, cabozantinib, BMS.599626, sorafenib, GTP.14564, UNC2250",0.00877392430750515,0.000869458712628891,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",-0.33319,-0.816,0.713,1112,0.841,"sunitinib, linifanib, cabozantinib, PD.173074, ENMD.2076, axitinib, sorafenib, MK.2461, lenvatinib, MGCD.265, lucitanib, tivozanib, KI.8751",0.146910470148134,0.0752040042020878,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",-0.52272,-1.27,0.206,1150,0.556,"maxacalcitol, paricalcitol, tacalcitol",0.686132779630847,0.254925208417942,FALSE
+"HCC78","Pearson.est","EGFR inhibitor",0.32835,0.938,0.496,233,0.653,"pelitinib, canertinib, erlotinib, vandetanib, afatinib, XL.647, brigatinib, BMS.690514, rociletinib, dacomitinib, poziotinib, PD.168393, AZD8931, lapatinib, neratinib",0.304518323509803,0.185086818724926,FALSE
+"HCC78","Pearson.est","Abl kinase inhibitor",-0.57238,-1.4,0.102,1109,0.538,"nilotinib, metatinib, flumatinib, imatinib, KW.2449, ponatinib, tozasertib",0.991399828238082,0.269217724333611,FALSE
+"HCC78","Pearson.est","acetylcholine receptor agonist",-0.39333,-0.96,0.51,1054,0.799,"nicotine, nefiracetam, pilocarpine",0.292429823902064,0.0974532206860086,FALSE
+"HCC78","Pearson.est","acetylcholine receptor antagonist",-0.44155,-1.08,0.368,641,0.717,"darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.434152181326482,0.1444808443322,FALSE
+"HCC78","Pearson.est","adenosine receptor antagonist",-0.55507,-1.32,0.138,1151,0.496,"MRS.1220, CGS.15943, SCH.58261",0.860120913598763,0.304518323509803,FALSE
+"HCC78","Pearson.est","adrenergic receptor agonist",-0.40626,-0.981,0.497,1060,0.797,"A61603, clenbuterol, isoxsuprine, isoetharine, norepinephrine, buphenine",0.303643611266668,0.0985416786038876,FALSE
+"HCC78","Pearson.est","adrenergic receptor antagonist",0.40319,1.13,0.29,231,0.751,"prazosin, vincamine, RS.17053, imiloxan, practolol, atenolol...., levobunolol, dihydroergocristine",0.537602002101044,0.124360062995832,FALSE
+"HCC78","Pearson.est","AKT inhibitor",-0.57059,-1.4,0.122,994,0.538,"MK.2206, GDC.0068, triciribine, ONC201, CCT128930, uprosertib, A.674563",0.913640169325252,0.269217724333611,FALSE
+"HCC78","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.32662,-0.809,0.697,987,0.788,"NVP.TAE684, CEP.37440, AZD3463, AP26113, alectinib, DMH1",0.156767221901991,0.103473782510445,FALSE
+"HCC78","Pearson.est","androgen receptor antagonist",-0.46476,-1.13,0.319,792,0.726,"nilutamide, flutamide, bicalutamide",0.496209316942819,0.139063379299906,FALSE
+"HCC78","Pearson.est","antioxidant",-0.41114,-0.991,0.49,1246,0.797,"benfotiamine, trolox",0.309803919971486,0.0985416786038876,FALSE
+"HCC78","Pearson.est","AP inhibitor",0.61263,1.72,0.0342,27,0.402,"birinapant, GDC.0152",1.46597389394386,0.39577394691553,FALSE
+"HCC78","Pearson.est","ATPase inhibitor",0.36731,1.09,0.351,119,0.681,"k.strophanthidin, ouabain, digitoxin",0.454692883534176,0.166852888087215,FALSE
+"HCC78","Pearson.est","Aurora kinase inhibitor",-0.64598,-1.59,0.0338,1121,0.735,"CCT129202, CCT137690, barasertib.HQPA, aurora.a.inhibitor.i, KW.2449, ENMD.2076, SNS.314, PF.03814735, AMG900, MK.8745, AT.9283, barasertib, hesperadin, tozasertib",1.47108329972235,0.133712660915805,FALSE
+"HCC78","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.63582,-1.55,0.0397,932,0.561,"azithromycin, azalomycin.b, josamycin, tilmicosin, valnemulin, radezolid, dirithromycin",1.40120949323689,0.251037138743839,FALSE
+"HCC78","Pearson.est","bacterial DNA gyrase inhibitor",0.54756,1.55,0.0992,259,0.504,"finafloxacin, sarafloxacin, novobiocin, sparfloxacin",1.00348832784582,0.297569463554475,FALSE
+"HCC78","Pearson.est","BCL inhibitor",-0.45426,-1.11,0.352,1198,0.721,"gossypol, ABT.737",0.453457336521869,0.142064735280571,FALSE
+"HCC78","Pearson.est","Bcr.Abl kinase inhibitor",-0.55739,-1.36,0.125,1109,0.56,"nilotinib, metatinib, flumatinib, imatinib, ponatinib, tozasertib",0.903089986991944,0.2518119729938,FALSE
+"HCC78","Pearson.est","benzodiazepine receptor agonist",0.28544,0.798,0.717,100,0.809,"ZK.93423, gamma.aminobutyric.acid, eprinomectin",0.1444808443322,0.0920514783877277,FALSE
+"HCC78","Pearson.est","bromodomain inhibitor",-0.72862,-1.78,0.00664,1074,0.52,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.17783192063198,0.283996656365201,FALSE
+"HCC78","Pearson.est","calcium channel blocker",-0.59375,-1.48,0.0612,1224,0.608,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.21324857785444,0.216096420727265,FALSE
+"HCC78","Pearson.est","CC chemokine receptor antagonist",-0.49986,-1.2,0.255,1043,0.664,"SB.225002, PF.04136309, navarixin",0.593459819566045,0.177831920631982,FALSE
+"HCC78","Pearson.est","CDK inhibitor",-0.51005,-1.23,0.207,1094,0.652,"AZD5438, NU6027, BMS.265246, palbociclib, indisulam, JNJ.7706621, ribociclib, kenpaullone, abemaciclib, indirubin, R547, arcyriaflavin.a",0.684029654543082,0.18575240426808,FALSE
+"HCC78","Pearson.est","CHK inhibitor",0.41098,1.14,0.265,167,0.832,"SCH.900776, CHIR.124, LY2603618",0.576754126063192,0.0798766737092761,FALSE
+"HCC78","Pearson.est","cyclooxygenase inhibitor",-0.31447,-0.77,0.766,940,0.823,"FK.3311, curcumin, indoprofen, piroxicam, tepoxalin, naproxen, aspirin, pterostilbene, FR.122047, tryptanthrin",0.115771230367396,0.0846001647877302,FALSE
+"HCC78","Pearson.est","cytochrome P450 inhibitor",0.35888,1.05,0.365,281,0.701,"PF.4981517, morin, eplerenone, metyrapone",0.437707135543525,0.154281982033341,FALSE
+"HCC78","Pearson.est","DNA alkylating agent",-0.38882,-0.942,0.525,875,0.743,"streptozotocin, cisplatin, temozolomide, carmustine, ifosfamide, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.279840696594043,0.129011186239425,FALSE
+"HCC78","Pearson.est","DNA inhibitor",-0.34224,-0.829,0.694,1081,0.787,"tirapazamine, pibenzimol, metronidazole, primaquine, melphalan, mechlorethamine",0.158640529545145,0.104025267640935,FALSE
+"HCC78","Pearson.est","DNA methyltransferase inhibitor",-0.39166,-0.948,0.512,1036,0.766,"fdcyd, disulfiram, RG108",0.290730039024169,0.115771230367396,FALSE
+"HCC78","Pearson.est","DNA polymerase inhibitor",-0.28552,-0.694,0.85,941,0.871,"idoxuridine, cidofovir, trifluridine, foscarnet",0.0705810742857073,0.0599818449923368,FALSE
+"HCC78","Pearson.est","DNA synthesis inhibitor",-0.43121,-1.04,0.407,848,0.759,"cyclocytidine, azodicarbonamide, cisplatin, estramustine.phosphate, artesunate, anisomycin, altretamine, CB.10.277, enocitabine, mitomycin.c",0.39040559077478,0.11975822410452,FALSE
+"HCC78","Pearson.est","dopamine receptor antagonist",-0.37789,-0.927,0.567,1071,0.738,"UH.232...., nemonapride, paliperidone, lurasidone, mesoridazine",0.246416941107093,0.131943638176958,FALSE
+"HCC78","Pearson.est","estrogen receptor agonist",0.49882,1.46,0.0938,152,0.515,"levonorgestrel, PPT, ethinyl.estradiol",1.02779716162094,0.288192770958809,FALSE
+"HCC78","Pearson.est","estrogen receptor antagonist",-0.65125,-1.58,0.0277,1242,0.581,"toremifene, danazol, fulvestrant",1.55752023093555,0.235823867609669,FALSE
+"HCC78","Pearson.est","FGFR inhibitor",-0.54572,-1.34,0.143,1137,0.536,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",0.844663962534938,0.27083521030723,FALSE
+"HCC78","Pearson.est","FLT3 inhibitor",-0.61919,-1.51,0.0574,1021,0.594,"TG.02, midostaurin, sunitinib, pacritinib, tandutinib, GTP.14564, KW.2449, ENMD.2076, TG.101348, ponatinib, sorafenib, quizartinib, tozasertib",1.24108810760203,0.226213555018806,FALSE
+"HCC78","Pearson.est","glucocorticoid receptor agonist",0.49733,1.39,0.124,279,0.443,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, halcinonide, fluocinolone.acetonide, triamcinolone.acetonide, ciclesonide, prednisolone, desonide, fludroxycortide",0.906578314837765,0.35359627377693,FALSE
+"HCC78","Pearson.est","glutamate receptor antagonist",0.36664,1.03,0.4,248,0.68,"SIB.1757, latrepirdine, kynurenic.acid, CPP, JNJ.16259685, CGP.37849",0.397940008672038,0.167491087293764,FALSE
+"HCC78","Pearson.est","glycogen synthase kinase inhibitor",-0.55919,-1.35,0.135,1234,0.546,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, CHIR.98014, indirubin",0.869666231504994,0.262807357295263,FALSE
+"HCC78","Pearson.est","growth factor receptor inhibitor",-0.49067,-1.2,0.23,844,0.664,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.638272163982407,0.177831920631982,FALSE
+"HCC78","Pearson.est","HCV inhibitor",0.2493,0.717,0.804,64,0.846,"daclatasvir",0.0947439512515487,0.0726296369609765,FALSE
+"HCC78","Pearson.est","HDAC inhibitor",-0.56849,-1.39,0.103,1112,0.522,"PCI.24781, scriptaid, dacinostat, panobinostat, AR.42, trichostatin.a, givinostat, vorinostat, RG2833, M.344, R306465, resminostat, RGFP966",0.987162775294828,0.282329496997738,FALSE
+"HCC78","Pearson.est","histamine receptor antagonist",-0.2994,-0.729,0.815,1079,0.846,"tecastemizole, lafutidine, cyproheptadine, BF2.649, epinastine",0.0888423912600234,0.0726296369609765,FALSE
+"HCC78","Pearson.est","HMGCR inhibitor",-0.2106,-0.514,0.979,927,0.972,"fluvastatin, lovastatin",0.00921730819686218,0.0123337350737254,FALSE
+"HCC78","Pearson.est","HSP inhibitor",0.48119,1.41,0.108,186,0.496,"BIIB021, KW.2478, SNX.2112, alvespimycin, SNX.5422",0.96657624451305,0.304518323509803,FALSE
+"HCC78","Pearson.est","JAK inhibitor",-0.414,-1.01,0.452,918,0.8,"CEP.33779, lestaurtinib, LY2784544, TG.02, AZD1480, pacritinib, TG.101348, AT.9283, TG.101209, tozasertib",0.344861565188618,0.0969100130080564,FALSE
+"HCC78","Pearson.est","KIT inhibitor",-0.43822,-1.09,0.334,953,0.718,"regorafenib, telatinib, midostaurin, sunitinib, tandutinib, lenvatinib, imatinib, sorafenib, KI.8751, masitinib",0.476253533188435,0.1438755557577,FALSE
+"HCC78","Pearson.est","MDM inhibitor",-0.49633,-1.23,0.214,1232,0.652,"serdemetan, RITA",0.669586226650809,0.18575240426808,FALSE
+"HCC78","Pearson.est","MEK inhibitor",0.62868,1.74,0.036,166,0.734,"selumetinib, AS.703026, trametinib, Ro.4987655, MEK1.2.inhibitor, TAK.733, AZD8330, PD.198306, cobimetinib, PD.0325901",1.44369749923271,0.134303940083929,FALSE
+"HCC78","Pearson.est","MET inhibitor",-0.68743,-1.68,0.0228,1390,0.584,"NVP.BVU972, AMG458",1.64206515299955,0.233587152887601,FALSE
+"HCC78","Pearson.est","microtubule inhibitor",-0.2272,-0.545,0.951,1327,0.974,"D.64131",0.0218194830625861,0.0114410431213845,FALSE
+"HCC78","Pearson.est","mTOR inhibitor",-0.46212,-1.13,0.305,766,0.726,"deforolimus, AZD8055, GDC.0980, OSI.027, NVP.BEZ235, voxtalisib, WYE.125132, temsirolimus, PKI.179, torin.2, MLN0128, sirolimus, LY303511, XL388, torin.1, PF.04691502, LY3023414, ku.0063794, GSK2126458, WYE.354, AZD2014, SB.2343",0.515700160653214,0.139063379299906,FALSE
+"HCC78","Pearson.est","NFkB pathway inhibitor",-0.39461,-0.959,0.514,1343,0.781,"EVP4593, betulinic.acid",0.289036881004724,0.1073489661227,FALSE
+"HCC78","Pearson.est","opioid receptor agonist",-0.35051,-0.845,0.651,897,0.778,"salvinorin.a, trimebutine, cebranopadol",0.186419011431808,0.109020403010311,FALSE
+"HCC78","Pearson.est","p38 MAPK inhibitor",-0.45257,-1.11,0.334,1326,0.721,"SB.239063, skepinone.l",0.476253533188435,0.142064735280571,FALSE
+"HCC78","Pearson.est","PARP inhibitor",-0.58442,-1.41,0.101,1139,0.613,"AG.14361, PJ.34, niraparib, E7449",0.995678626217357,0.212539525481585,FALSE
+"HCC78","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49034,-1.19,0.255,1108,0.661,"sunitinib, linifanib, crenolanib, axitinib, tandutinib, lenvatinib, imatinib, ponatinib, sorafenib, KI.8751, masitinib",0.593459819566045,0.17979854051436,FALSE
+"HCC78","Pearson.est","phosphatase inhibitor",-0.43242,-1.05,0.386,769,0.759,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV., AS.1949490, BVT.948, CID.5458317, alexidine, GSK2830371",0.413412695328245,0.11975822410452,FALSE
+"HCC78","Pearson.est","phosphodiesterase inhibitor",0.29424,0.814,0.644,121,0.828,"cilostamide, EMD.53998",0.191114132640188,0.0819696632151199,FALSE
+"HCC78","Pearson.est","PI3K inhibitor",-0.39446,-0.964,0.494,782,0.812,"GDC.0980, TG100.115, YM.201636, NVP.BEZ235, voxtalisib, PKI.179, AZD6482, TG.100713, BGT226, PI3K.IN.2, LY303511, PF.04691502, LY3023414, GDC.0941, GSK2126458, CUDC.907, CH5132799, SB.2343",0.306273051076353,0.0904439707588247,FALSE
+"HCC78","Pearson.est","PLK inhibitor",-0.3918,-0.95,0.532,742,0.781,"GSK461364, NMS.1286937, BI.2536, rigosertib, volasertib, GW.843682X",0.274088367704952,0.1073489661227,FALSE
+"HCC78","Pearson.est","potassium channel blocker",0.31137,0.945,0.474,999,0.731,"dofetilide, mepivacaine, oleoylethanolamide, ibutilide, meglitinide, ML133",0.324221658325915,0.13608262304214,FALSE
+"HCC78","Pearson.est","PPAR receptor agonist",-0.37485,-0.908,0.576,1270,0.74,"pterostilbene",0.239577516576788,0.130768280269024,FALSE
+"HCC78","Pearson.est","progesterone receptor agonist",-0.33876,-0.822,0.685,1321,0.784,"melengestrol.acetate, danazol",0.164309428507574,0.105683937315562,FALSE
+"HCC78","Pearson.est","proteasome inhibitor",0.38967,1.12,0.305,108,0.69,"MG.132, carfilzomib",0.515700160653214,0.161150909262745,FALSE
+"HCC78","Pearson.est","protein synthesis inhibitor",0.25938,0.761,0.754,282,0.825,"clofoctol, cycloheximide, chloramphenicol.palmitate, homoharringtonine, bruceantin, puromycin, methacycline, anguidine",0.122628654130226,0.0835460514500749,FALSE
+"HCC78","Pearson.est","protein tyrosine kinase inhibitor",-0.41233,-0.995,0.473,1134,0.811,"mubritinib, NVP.TAE226, BMS.599626",0.325138859262188,0.090979145788844,FALSE
+"HCC78","Pearson.est","RAF inhibitor",-0.30335,-0.737,0.792,1200,0.85,"RAF265, sorafenib, TAK.632",0.101274818410506,0.0705810742857073,FALSE
+"HCC78","Pearson.est","RET tyrosine kinase inhibitor",-0.38638,-0.947,0.531,953,0.75,"regorafenib, sunitinib, cabozantinib, sorafenib",0.274905478918531,0.1249387366083,FALSE
+"HCC78","Pearson.est","retinoid receptor agonist",-0.58651,-1.44,0.0824,1239,0.661,"adapalene, fenretinide, bexarotene",1.08407278830288,0.17979854051436,FALSE
+"HCC78","Pearson.est","ribonucleotide reductase inhibitor",-0.35868,-0.869,0.618,828,0.786,"cytarabine, clofarabine, fludarabine, cladribine, pentostatin",0.209011524911184,0.104577453960592,FALSE
+"HCC78","Pearson.est","serotonin receptor agonist",-0.54406,-1.32,0.152,1204,0.496,"ipsapirone, aripiprazole",0.818156412055227,0.304518323509803,FALSE
+"HCC78","Pearson.est","serotonin receptor antagonist",-0.47017,-1.13,0.333,1189,0.726,"paliperidone, lurasidone, aripiprazole",0.47755576649368,0.139063379299906,FALSE
+"HCC78","Pearson.est","sodium channel blocker",-0.44989,-1.09,0.344,1245,0.718,"quinidine, triamterene, ajmaline, lappaconite",0.46344155742847,0.1438755557577,FALSE
+"HCC78","Pearson.est","src inhibitor",0.3661,1.02,0.381,19,0.644,"dasatinib, saracatinib",0.419075024324381,0.191114132640188,FALSE
+"HCC78","Pearson.est","sterol demethylase inhibitor",-0.53445,-1.32,0.161,1026,0.496,"terconazole, ketoconazole",0.79317412396815,0.304518323509803,FALSE
+"HCC78","Pearson.est","TGF beta receptor inhibitor",-0.3472,-0.854,0.658,1387,0.795,"adaprev",0.181774106386044,0.0996328713435297,FALSE
+"HCC78","Pearson.est","thymidylate synthase inhibitor",0.32741,0.938,0.506,229,0.653,"capecitabine, ftorafur, doxifluridine",0.295849483160201,0.185086818724926,FALSE
+"HCC78","Pearson.est","topoisomerase inhibitor",-0.37515,-0.919,0.563,772,0.736,"daunorubicin, exatecan.mesylate, valrubicin, beta.lapachone, voreloxin, etoposide.phosphate, camptothecin, topotecan, nemorubicin, fleroxacin, SN.38, dexrazoxane, TAS.103, rubitecan, genz.644282, irinotecan",0.249491605148654,0.133122185662501,FALSE
+"HCC78","Pearson.est","tubulin polymerization inhibitor",0.15631,0.445,0.991,4,0.994,"mebendazole",0.00392634551472468,0.00261361560268669,FALSE
+"HCC78","Pearson.est","tyrosine kinase inhibitor",-0.3472,-0.849,0.651,1108,0.787,"sunitinib, mubritinib, cabozantinib, NVP.TAE226, BMS.599626, GTP.14564, sorafenib, UNC2250",0.186419011431808,0.104025267640935,FALSE
+"HCC78","Pearson.est","VEGFR inhibitor",-0.38416,-0.929,0.578,1108,0.75,"sunitinib, PD.173074, linifanib, MK.2461, axitinib, cabozantinib, RAF265, lenvatinib, ENMD.2076, MGCD.265, sorafenib, lucitanib, tivozanib, KI.8751",0.238072161579471,0.1249387366083,FALSE
+"HCC78","Pearson.est","vitamin D receptor agonist",-0.59629,-1.43,0.0939,1291,0.615,"paricalcitol, maxacalcitol, tacalcitol",1.02733440773389,0.211124884224583,FALSE
+"H2126","Pearson.est","EGFR inhibitor",0.41056,1.19,0.233,188,0.641,"pelitinib, canertinib, vandetanib, XL.647, BMS.690514, rociletinib, erlotinib, brigatinib, afatinib, CUDC.101, AZD8931, dacomitinib, neratinib, lapatinib",0.632644078973981,0.193141970481183,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",-0.45944,-1.13,0.316,1106,0.721,"KW.2449, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.500312917381596,0.142064735280571,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",-0.48685,-1.18,0.292,1222,0.662,"nicotine, nefiracetam, pilocarpine",0.534617148551582,0.1791420105603,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",-0.46047,-1.11,0.341,664,0.666,"darifenacin, hyoscyamine, diphemanil, dicycloverine, methscopolamine, iododexetimide",0.467245621007502,0.176525770829699,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.53524,-1.25,0.207,869,0.677,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.684029654543082,0.169411331314856,FALSE
+"H2126","Pearson.est","adrenergic receptor agonist",-0.38459,-0.932,0.528,773,0.81,"methyldopa, midodrine, xylazine, ritodrine, clenbuterol, A61603, isoxsuprine, isoetharine, buphenine, norepinephrine",0.277366077466188,0.0915149811213502,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",0.40152,1.13,0.29,267,0.63,"prazosin, vincamine, RS.17053, practolol, levobunolol, dihydroergocristine, idazoxan, atenolol....",0.537602002101044,0.200659450546418,FALSE
+"H2126","Pearson.est","AKT inhibitor",-0.40313,-0.971,0.488,1085,0.777,"ONC201, uprosertib, A.674563, CCT128930",0.311580177997289,0.109578981199086,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.28079,-0.692,0.834,1190,0.903,"alectinib, AP26113, DMH1",0.0788339493622613,0.0443122496864942,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",-0.61302,-1.49,0.0584,1031,0.774,"nilutamide, flutamide, bicalutamide",1.2335871528876,0.111259039317107,FALSE
+"H2126","Pearson.est","antioxidant",-0.50492,-1.21,0.248,1337,0.681,"benfotiamine, trolox",0.605548319173784,0.166852888087215,FALSE
+"H2126","Pearson.est","AP inhibitor",0.5066,1.44,0.0789,49,0.638,"birinapant, GDC.0152",1.10292299679058,0.195179321278838,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.28977,0.794,0.701,170,0.884,"k.strophanthidin, digitoxin, blebbistatin....",0.154281982033341,0.0535477349869269,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",-0.57664,-1.4,0.105,1083,0.789,"CCT129202, barasertib.HQPA, KW.2449, AMG900, aurora.a.inhibitor.i, SNS.314, AT.9283, barasertib, ENMD.2076, MK.8745, PF.03814735, hesperadin, tozasertib",0.978810700930062,0.10292299679058,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.55121,-1.36,0.137,910,0.764,"azalomycin.b, azithromycin, tilmicosin, josamycin, radezolid, dirithromycin",0.863279432843593,0.11690664142431,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.45362,1.22,0.194,159,0.658,"novobiocin, finafloxacin, sarafloxacin",0.712198270069774,0.181774106386044,FALSE
+"H2126","Pearson.est","BCL inhibitor",-0.49332,-1.2,0.237,1147,0.644,"gossypol, ABT.737",0.625251653989896,0.191114132640188,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",-0.44422,-1.08,0.379,1118,0.684,"nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.421360790031928,0.164943898279884,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",0.2112,0.588,0.916,78,1,"ZK.93423, gamma.aminobutyric.acid",0.0381045263321496,0,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",-0.56044,-1.36,0.125,1038,0.764,"JQ1...., PFI.1, I.BET151, bromosporine",0.903089986991944,0.11690664142431,FALSE
+"H2126","Pearson.est","calcium channel blocker",-0.58841,-1.41,0.102,1238,0.857,"cinnarazine, mibefradil, carboxyamidotriazole, SR.33805",0.991399828238082,0.0670191780768018,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",-0.3583,-0.874,0.636,936,0.835,"SB.225002, PF.04136309, navarixin",0.196542884351586,0.0783135245163979,FALSE
+"H2126","Pearson.est","CDK inhibitor",-0.30728,-0.746,0.792,880,0.924,"AZD5438, indisulam, BMS.265246, abemaciclib, JNJ.7706621, ribociclib, kenpaullone, NU6027, indirubin, R547, arcyriaflavin.a",0.101274818410506,0.0343280287798933,FALSE
+"H2126","Pearson.est","CHK inhibitor",0.5521,1.55,0.0769,91,0.58,"SCH.900776, CHIR.124, LY2603618",1.11407366019857,0.236572006437063,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.34065,-0.82,0.693,1078,0.868,"tepoxalin, indoprofen, piroxicam, FK.3311, metoxibutropate, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.159266765388193,0.0614802748235081,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",0.26995,0.78,0.765,317,0.863,"PF.4981517, morin, eplerenone, metyrapone",0.116338564846382,0.0639892042847904,FALSE
+"H2126","Pearson.est","DNA alkylating agent",-0.35047,-0.856,0.65,1079,0.846,"carmustine, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.187086643357144,0.0726296369609765,FALSE
+"H2126","Pearson.est","DNA inhibitor",-0.44556,-1.09,0.365,1079,0.686,"carmustine, carboplatin, pibenzimol, metronidazole, primaquine, melphalan, tirapazamine, mechlorethamine",0.437707135543525,0.163675884293248,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",-0.31079,-0.752,0.77,1256,0.935,"RG108, disulfiram",0.113509274827518,0.0291883891274822,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",0.29375,0.828,0.671,1025,0.921,"cephalomannine, menadione, famciclovir, idoxuridine, adefovir.dipivoxil, trifluridine, foscarnet, cidofovir",0.173277479831008,0.0357403698031511,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",-0.33076,-0.801,0.714,1059,0.88,"estramustine.phosphate, enocitabine, CB.10.277, altretamine, mitomycin.c",0.146301788223826,0.0555173278498314,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.41521,-1.01,0.452,792,0.72,"ziprasidone, oxiperomide, domperidone, raclopride, amisulpride, paliperidone, nemonapride, UH.232...., lurasidone, mesoridazine",0.344861565188618,0.142667503568732,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",0.46711,1.29,0.179,47,0.602,"PPT, levonorgestrel",0.747146969020107,0.220403508742175,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",-0.73645,-1.76,0.0093,1317,0.559,"toremifene, fulvestrant, danazol",2.03151705144606,0.252588192113577,FALSE
+"H2126","Pearson.est","FGFR inhibitor",-0.64909,-1.57,0.0362,1036,1,"orantinib, PD.173074, MK.2461, erdafitinib, lenvatinib, lucitanib",1.44129142946683,0,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",-0.60396,-1.45,0.0832,1041,0.812,"sunitinib, sorafenib, KW.2449, midostaurin, TG.101348, tandutinib, ENMD.2076, ponatinib, GTP.14564, quizartinib, tozasertib",1.07987667370928,0.0904439707588247,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",0.42079,1.18,0.241,285,0.595,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, fluocinolone.acetonide, prednisolone, desonide, halcinonide, triamcinolone.acetonide, fludroxycortide",0.617982957425132,0.22548303427145,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.27903,-0.68,0.852,1314,0.9,"MTPG, IEM1754",0.0695604052332999,0.0457574905606751,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.51053,-1.25,0.2,1134,0.677,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.698970004336019,0.169411331314856,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",-0.45613,-1.11,0.307,788,0.666,"AZD3463, lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.512861624522813,0.176525770829699,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.31429,0.891,0.515,56,0.847,"daclatasvir",0.288192770958809,0.0721165896692931,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.45423,-1.11,0.342,865,0.666,"ACY.1215, scriptaid, romidepsin, PCI.24781, dacinostat, entinostat, panobinostat, AR.42, vorinostat, givinostat, trichostatin.a, RG2833, resminostat, M.344, R306465, RGFP966",0.465973893943865,0.176525770829699,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",-0.36822,-0.906,0.575,1188,0.837,"lafutidine, BF2.649, tecastemizole, epinastine",0.24033215531037,0.07727454200674,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",-0.53292,-1.3,0.166,1285,0.713,"lovastatin, fluvastatin",0.779891911959945,0.146910470148134,FALSE
+"H2126","Pearson.est","HSP inhibitor",0.56643,1.62,0.0522,292,0.681,"BIIB021, KW.2478, SNX.5422, NVP.AUY922, alvespimycin, SNX.2112, ganetespib, VER.49009",1.28232949699774,0.166852888087215,FALSE
+"H2126","Pearson.est","JAK inhibitor",-0.30905,-0.743,0.782,966,0.91,"LY2784544, CEP.33779, AZD1480, AT.9283, TG.101348, TG.101209, tozasertib",0.106793246940152,0.0409586076789064,FALSE
+"H2126","Pearson.est","KIT inhibitor",-0.44369,-1.06,0.396,1041,0.703,"sunitinib, sorafenib, midostaurin, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.402304814074488,0.153044674980176,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.46002,-1.12,0.329,1389,0.716,"RITA",0.482804102050026,0.145086977692144,FALSE
+"H2126","Pearson.est","MEK inhibitor",0.66636,1.96,0.0178,165,0.286,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.74957999769111,0.543633966870957,FALSE
+"H2126","Pearson.est","MET inhibitor",-0.62803,-1.53,0.0495,1415,1,"NVP.BVU972, AMG458",1.30539480106643,0,FALSE
+"H2126","Pearson.est","microtubule inhibitor",0.19193,0.555,0.969,1172,1,"secnidazole, triclabendazole, vinflunine, vinblastine, podophyllotoxin, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0136762229492347,0,FALSE
+"H2126","Pearson.est","mTOR inhibitor",-0.43347,-1.03,0.438,1076,0.702,"XL388, sirolimus, LY303511, GSK2126458, LY3023414, PF.04691502, torin.1, AZD2014, WYE.354, ku.0063794, SB.2343",0.3585258894959,0.153662887870195,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.22064,-0.537,0.959,1230,0.963,"EVP4593, betulinic.acid",0.0181813928293364,0.0163737128754655,FALSE
+"H2126","Pearson.est","opioid receptor agonist",-0.52431,-1.3,0.181,927,0.713,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.742321425130815,0.146910470148134,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",-0.4687,-1.14,0.321,993,0.726,"SB.242235, TAK.715, SB.239063, skepinone.l",0.493494967595128,0.139063379299906,FALSE
+"H2126","Pearson.est","PARP inhibitor",-0.62992,-1.51,0.0552,1179,0.86,"AG.14361, niraparib, PJ.34, E7449",1.2580609222708,0.0655015487564323,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49416,-1.2,0.259,1036,0.644,"orantinib, sunitinib, crenolanib, axitinib, sorafenib, linifanib, imatinib, tandutinib, ponatinib, lenvatinib, KI.8751, masitinib",0.586700235918748,0.191114132640188,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",-0.50958,-1.25,0.202,835,0.677,"bis.maltolato.oxovanadium.IV., AS.1949490, sodium.stibogluconate, CID.5458317, alexidine, GSK2830371, BVT.948",0.694648630553376,0.169411331314856,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",0.21627,0.608,0.925,1137,1,"cilostamide, EMD.53998, enoximone, anagrelide, avanafil, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.0338582672609674,0,FALSE
+"H2126","Pearson.est","PI3K inhibitor",-0.42425,-1.04,0.406,786,0.701,"TG100.115, YM.201636, PI3K.IN.2, pilaralisib, PKI.179, PI.828, voxtalisib, BGT226, TG.100713, LY303511, GSK2126458, AZD6482, LY3023414, PF.04691502, GDC.0941, CUDC.907, CH5132799, SB.2343",0.391473966422806,0.154281982033341,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.28799,0.819,0.662,1033,0.888,"HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.1791420105603,0.051587034221399,FALSE
+"H2126","Pearson.est","potassium channel blocker",-0.21903,-0.54,0.955,1093,0.978,"ibutilide, meglitinide",0.0199966284162537,0.00966114521239857,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",-0.42109,-1.04,0.401,1324,0.701,"pterostilbene",0.396855627379818,0.154281982033341,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",-0.37235,-0.899,0.597,1145,0.811,"dienogest, melengestrol.acetate, danazol",0.224025668870631,0.090979145788844,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.45951,1.31,0.16,83,0.66,"carfilzomib, MG.132",0.795880017344075,0.180456064458131,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.34602,0.95,0.504,157,0.97,"homoharringtonine, cycloheximide, clofoctol, anguidine, bruceantin, chloramphenicol.palmitate",0.297569463554475,0.0132282657337552,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.29335,-0.708,0.821,669,0.901,"CP.724714, PP.121, rheochrysidin, NVP.TAE226, mubritinib, BMS.599626",0.0856568428805592,0.045275209020937,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.32618,0.922,0.508,87,0.896,"AZ.628, LGX818, vemurafenib",0.294136287716081,0.0476919903378748,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.32823,0.92,0.512,24,0.841,"vandetanib",0.290730039024169,0.0752040042020878,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",-0.49512,-1.21,0.241,1206,0.681,"fenretinide, adapalene, bexarotene",0.617982957425132,0.166852888087215,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",-0.31139,-0.735,0.801,791,0.903,"hydroxyurea, cytarabine, fludarabine, clofarabine, cladribine, pentostatin",0.0963674839157623,0.0443122496864942,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",-0.56098,-1.35,0.136,1000,0.727,"zolmitriptan, NAN.190, ipsapirone, aripiprazole",0.866461091629782,0.138465589140962,FALSE
+"H2126","Pearson.est","serotonin receptor antagonist",-0.50387,-1.22,0.232,1363,0.725,"lurasidone, aripiprazole",0.6345120151091,0.139661993429006,FALSE
+"H2126","Pearson.est","sodium channel blocker",-0.39731,-0.959,0.513,1027,0.779,"A.803467, oxcarbazepine, ajmaline, triamterene, quinidine, lappaconite",0.289882634888184,0.108462542327436,FALSE
+"H2126","Pearson.est","src inhibitor",-0.35528,-0.847,0.656,1185,0.843,"KX2.391, PP.1, masitinib",0.18309616062434,0.0741724253752577,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",-0.52827,-1.29,0.162,1142,0.694,"terconazole, ketoconazole",0.790484985457369,0.158640529545145,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",-0.37231,-0.901,0.573,1379,0.826,"adaprev",0.24184537803261,0.0830199526796178,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.48569,1.4,0.0915,247,0.585,"capecitabine, doxifluridine, ftorafur",1.03857890593355,0.23284413391782,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",-0.23043,-0.569,0.941,890,0.979,"etoposide.phosphate, rubitecan, valrubicin, nemorubicin, voreloxin, SN.38, TAS.103, genz.644282, fleroxacin, dexrazoxane, irinotecan",0.0264103765727431,0.00921730819686218,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.33226,0.949,0.498,399,0.898,"mebendazole, paclitaxel, BNC105, vindesine, CYT.997, vincristine, epothilone.b, taltobulin, vinorelbine, oxibendazole, fosbretabulin, verubulin, vinblastine, dolastatin.10, fenbendazole, podophyllotoxin",0.302770657240282,0.0467236633326956,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",0.18499,0.522,0.989,24,0.976,"dasatinib, vandetanib",0.0048037084028206,0.0105501823333082,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",-0.30424,-0.734,0.805,1036,0.887,"orantinib, sunitinib, cabozantinib, axitinib, sorafenib, PD.173074, linifanib, ENMD.2076, MK.2461, lenvatinib, tivozanib, lucitanib, MGCD.265, KI.8751",0.0942041196321315,0.0520763801682736,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.5563,-1.33,0.144,922,0.732,"alfacalcidol, ercalcitriol, maxacalcitol, tacalcitol, paricalcitol",0.84163750790475,0.135488918941608,FALSE
+"HCC827","Pearson.est","EGFR inhibitor",0.30987,0.87,0.578,215,1,"pelitinib, canertinib, brigatinib, vandetanib, XL.647, BMS.690514, rociletinib, erlotinib, afatinib, dacomitinib, lapatinib, AZD8931, poziotinib, neratinib",0.238072161579471,0,FALSE
+"HCC827","Pearson.est","Abl kinase inhibitor",-0.58133,-1.42,0.104,1181,0.646,"imatinib, nilotinib, KW.2449, flumatinib, ponatinib, tozasertib",0.98296666070122,0.189767482004916,FALSE
+"HCC827","Pearson.est","acetylcholine receptor agonist",-0.4664,-1.13,0.318,1162,0.694,"nicotine, nefiracetam, pilocarpine",0.497572880015567,0.158640529545145,FALSE
+"HCC827","Pearson.est","acetylcholine receptor antagonist",-0.52689,-1.29,0.174,1027,0.536,"dicycloverine, iododexetimide, methscopolamine",0.7594507517174,0.27083521030723,FALSE
+"HCC827","Pearson.est","adenosine receptor antagonist",-0.49502,-1.21,0.233,825,0.635,"sulmazole, istradefylline, MRS.1220, CGS.15943, SCH.58261",0.632644078973981,0.197226274708024,FALSE
+"HCC827","Pearson.est","adrenergic receptor agonist",-0.43868,-1.07,0.379,1076,0.756,"clenbuterol, A61603, isoxsuprine, isoetharine, buphenine, norepinephrine",0.421360790031928,0.121478204498793,FALSE
+"HCC827","Pearson.est","adrenergic receptor antagonist",0.42582,1.23,0.198,238,0.664,"prazosin, vincamine, RS.17053, practolol, imiloxan, dihydroergocristine, atenolol...., levobunolol, idazoxan",0.703334809738469,0.177831920631982,FALSE
+"HCC827","Pearson.est","AKT inhibitor",-0.4402,-1.05,0.409,1017,0.776,"triciribine, ONC201, uprosertib, A.674563, CCT128930",0.388276691992658,0.110138278741812,FALSE
+"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.34834,-0.835,0.667,1275,0.839,"alectinib, AP26113, DMH1",0.175874166083451,0.0762380391712997,FALSE
+"HCC827","Pearson.est","androgen receptor antagonist",-0.64412,-1.58,0.0381,1060,0.57,"nilutamide, flutamide, bicalutamide",1.41907502432438,0.244125144327509,FALSE
+"HCC827","Pearson.est","antioxidant",-0.52921,-1.31,0.158,1322,0.515,"benfotiamine, trolox",0.801342913045577,0.288192770958809,FALSE
+"HCC827","Pearson.est","AP inhibitor",0.60206,1.78,0.0299,34,0.683,"birinapant, GDC.0152",1.52432881167557,0.165579296318467,FALSE
+"HCC827","Pearson.est","ATPase inhibitor",0.28657,0.842,0.625,240,0.921,"k.strophanthidin, digitoxin, ouabain, blebbistatin....",0.204119982655925,0.0357403698031511,FALSE
+"HCC827","Pearson.est","Aurora kinase inhibitor",-0.59922,-1.46,0.0793,1123,0.787,"CCT129202, barasertib.HQPA, AMG900, aurora.a.inhibitor.i, KW.2449, ENMD.2076, AT.9283, SNS.314, MK.8745, PF.03814735, barasertib, hesperadin, tozasertib",1.1007268126824,0.104025267640935,FALSE
+"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54228,-1.32,0.15,820,0.55,"valnemulin, azithromycin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.823908740944319,0.259637310505756,FALSE
+"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",0.47629,1.36,0.123,174,0.617,"finafloxacin, sarafloxacin, novobiocin",0.910094888560602,0.209714835966758,FALSE
+"HCC827","Pearson.est","BCL inhibitor",-0.3903,-0.951,0.536,1125,0.784,"gossypol, ABT.737",0.27083521030723,0.105683937315562,FALSE
+"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.55909,-1.37,0.116,1181,0.525,"imatinib, nilotinib, flumatinib, ponatinib, tozasertib",0.935542010773082,0.279840696594043,FALSE
+"HCC827","Pearson.est","benzodiazepine receptor agonist",0.23932,0.678,0.86,45,0.939,"ZK.93423, gamma.aminobutyric.acid",0.0655015487564323,0.0273344077338891,FALSE
+"HCC827","Pearson.est","bromodomain inhibitor",-0.59094,-1.43,0.0841,1097,0.692,"PFI.1, JQ1...., bromosporine, I.BET151",1.07520400420209,0.159893905543242,FALSE
+"HCC827","Pearson.est","calcium channel blocker",-0.57453,-1.4,0.0978,1201,0.582,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.0096611452124,0.235077015350112,FALSE
+"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.41567,-0.995,0.463,735,0.778,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.334419008982047,0.109020403010311,FALSE
+"HCC827","Pearson.est","CDK inhibitor",-0.42795,-1.04,0.42,1015,0.773,"AZD5438, indisulam, BMS.265246, NU6027, JNJ.7706621, ribociclib, abemaciclib, kenpaullone, indirubin, R547, arcyriaflavin.a",0.3767507096021,0.111820506081675,FALSE
+"HCC827","Pearson.est","CHK inhibitor",0.48923,1.41,0.0952,122,0.645,"SCH.900776, CHIR.124, LY2603618",1.02136305161553,0.190440285364732,FALSE
+"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.3199,-0.774,0.741,901,0.846,"meloxicam, curcumin, metoxibutropate, FK.3311, indoprofen, tepoxalin, piroxicam, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.130181792020672,0.0726296369609765,FALSE
+"HCC827","Pearson.est","cytochrome P450 inhibitor",0.28647,0.788,0.675,292,0.816,"PF.4981517, morin, eplerenone, metyrapone",0.170696227168975,0.0883098412461389,FALSE
+"HCC827","Pearson.est","DNA alkylating agent",-0.4218,-1.01,0.45,961,0.771,"ifosfamide, carboplatin, temozolomide, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.346787486224656,0.112945621949043,FALSE
+"HCC827","Pearson.est","DNA inhibitor",-0.39887,-0.955,0.517,982,0.796,"carboplatin, carmustine, pibenzimol, primaquine, tirapazamine, metronidazole, melphalan, mechlorethamine",0.286509456906058,0.0990869322623309,FALSE
+"HCC827","Pearson.est","DNA methyltransferase inhibitor",0.28671,0.814,0.685,149,0.816,"decitabine, SGI.1027",0.164309428507574,0.0883098412461389,FALSE
+"HCC827","Pearson.est","DNA polymerase inhibitor",0.30278,0.855,0.6,1012,0.96,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.221848749616356,0.0177287669604316,FALSE
+"HCC827","Pearson.est","DNA synthesis inhibitor",-0.3576,-0.866,0.64,774,0.824,"cisplatin, anisomycin, nelarabine, artesunate, azodicarbonamide, altretamine, estramustine.phosphate, CB.10.277, enocitabine, mitomycin.c",0.193820026016113,0.0840727883028842,FALSE
+"HCC827","Pearson.est","dopamine receptor antagonist",-0.42314,-1.03,0.421,1168,0.772,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.375717904164332,0.112382699664264,FALSE
+"HCC827","Pearson.est","estrogen receptor agonist",0.43392,1.24,0.203,33,0.75,"PPT, levonorgestrel",0.692503962086787,0.1249387366083,FALSE
+"HCC827","Pearson.est","estrogen receptor antagonist",-0.72358,-1.76,0.0105,1272,0.598,"toremifene, danazol, fulvestrant",1.97881070093006,0.223298816011589,FALSE
+"HCC827","Pearson.est","FGFR inhibitor",-0.66853,-1.58,0.0273,1055,0.57,"orantinib, PD.173074, lenvatinib, erdafitinib, MK.2461, lucitanib",1.56383735295924,0.244125144327509,FALSE
+"HCC827","Pearson.est","FLT3 inhibitor",-0.57019,-1.36,0.125,1198,0.515,"KW.2449, ENMD.2076, sorafenib, GTP.14564, TG.101348, tandutinib, quizartinib, ponatinib, tozasertib",0.903089986991944,0.288192770958809,FALSE
+"HCC827","Pearson.est","glucocorticoid receptor agonist",0.37493,1.09,0.329,323,0.721,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, fluocinolone.acetonide, halcinonide, triamcinolone.acetonide, fludroxycortide, desonide",0.482804102050026,0.142064735280571,FALSE
+"HCC827","Pearson.est","glutamate receptor antagonist",0.29574,0.835,0.622,130,0.877,"SIB.1757, latrepirdine, kynurenic.acid",0.206209615309181,0.0570004066339595,FALSE
+"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.55618,-1.38,0.115,1197,0.541,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.939302159646388,0.266802734893431,FALSE
+"HCC827","Pearson.est","growth factor receptor inhibitor",-0.55928,-1.33,0.138,867,0.557,"lestaurtinib, GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.860120913598763,0.254144804826271,FALSE
+"HCC827","Pearson.est","HCV inhibitor",-0.28909,-0.701,0.825,1277,0.875,"narlaprevir",0.0835460514500749,0.0579919469776868,FALSE
+"HCC827","Pearson.est","HDAC inhibitor",-0.5403,-1.31,0.152,1211,0.515,"AR.42, panobinostat, trichostatin.a, givinostat, vorinostat, M.344, RG2833, resminostat, R306465, RGFP966",0.818156412055227,0.288192770958809,FALSE
+"HCC827","Pearson.est","histamine receptor antagonist",-0.31971,-0.78,0.738,1064,0.854,"cyproheptadine, lafutidine, tecastemizole, BF2.649, epinastine",0.131943638176958,0.068542129310995,FALSE
+"HCC827","Pearson.est","HMGCR inhibitor",-0.44162,-1.08,0.358,1179,0.76,"fluvastatin, lovastatin",0.446116973356126,0.119186407719209,FALSE
+"HCC827","Pearson.est","HSP inhibitor",0.59706,1.69,0.0259,286,0.321,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, VER.49009, ganetespib",1.58670023591875,0.493494967595128,FALSE
+"HCC827","Pearson.est","JAK inhibitor",-0.33876,-0.824,0.699,936,0.839,"LY2784544, pacritinib, CEP.33779, AZD1480, AT.9283, TG.101348, TG.101209, tozasertib",0.155522824254319,0.0762380391712997,FALSE
+"HCC827","Pearson.est","KIT inhibitor",-0.46876,-1.14,0.325,1041,0.696,"sunitinib, midostaurin, imatinib, sorafenib, lenvatinib, tandutinib, KI.8751, masitinib",0.488116639021126,0.157390760389438,FALSE
+"HCC827","Pearson.est","MDM inhibitor",-0.40389,-0.969,0.514,1089,0.789,"serdemetan, RITA",0.289036881004724,0.10292299679058,FALSE
+"HCC827","Pearson.est","MEK inhibitor",0.63532,1.77,0.0535,182,0.356,"selumetinib, AS.703026, trametinib, Ro.4987655, MEK1.2.inhibitor, TAK.733, AZD8330, cobimetinib, PD.198306, PD.0325901",1.27164621797877,0.448550002027125,FALSE
+"HCC827","Pearson.est","MET inhibitor",-0.66043,-1.59,0.0256,1410,1,"NVP.BVU972, AMG458",1.59176003468815,0,FALSE
+"HCC827","Pearson.est","microtubule inhibitor",-0.16612,-0.404,0.999,1061,0.997,"estramustine.phosphate, D.64131",0.000434511774017692,0.00130484168834428,FALSE
+"HCC827","Pearson.est","mTOR inhibitor",-0.35438,-0.867,0.647,1012,0.84,"XL388, LY303511, torin.1, LY3023414, GSK2126458, PF.04691502, ku.0063794, AZD2014, WYE.354, SB.2343",0.1890957193313,0.0757207139381184,FALSE
+"HCC827","Pearson.est","NFkB pathway inhibitor",-0.31328,-0.751,0.783,832,0.846,"bindarit, parthenolide, curcumin, bortezomib, EVP4593, betulinic.acid",0.106238237942057,0.0726296369609765,FALSE
+"HCC827","Pearson.est","opioid receptor agonist",-0.41465,-1.01,0.447,778,0.771,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.349692476868064,0.112945621949043,FALSE
+"HCC827","Pearson.est","p38 MAPK inhibitor",-0.45983,-1.1,0.359,1332,0.738,"SB.239063, skepinone.l",0.444905551421681,0.131943638176958,FALSE
+"HCC827","Pearson.est","PARP inhibitor",-0.60047,-1.45,0.0779,1160,0.711,"AG.14361, niraparib, PJ.34, E7449",1.10846254232744,0.148130399270234,FALSE
+"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.50659,-1.22,0.228,1041,0.672,"sunitinib, orantinib, linifanib, crenolanib, axitinib, imatinib, sorafenib, lenvatinib, tandutinib, ponatinib, KI.8751, masitinib",0.642065152999546,0.172630726946175,FALSE
+"HCC827","Pearson.est","phosphatase inhibitor",-0.48986,-1.17,0.274,821,0.706,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV., AS.1949490, CID.5458317, BVT.948, alexidine, GSK2830371",0.562249437179612,0.151195298948196,FALSE
+"HCC827","Pearson.est","phosphodiesterase inhibitor",0.22949,0.639,0.896,1118,0.938,"cilostamide, EMD.53998, enoximone, anagrelide, avanafil, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.0476919903378748,0.0277971616209356,FALSE
+"HCC827","Pearson.est","PI3K inhibitor",-0.37646,-0.905,0.576,843,0.83,"PI3K.IN.2, YM.201636, BGT226, TG100.115, TG.100713, LY303511, AZD6482, LY3023414, GSK2126458, PF.04691502, GDC.0941, CUDC.907, CH5132799, SB.2343",0.239577516576788,0.0809219076239261,FALSE
+"HCC827","Pearson.est","PLK inhibitor",0.21999,0.603,0.926,1131,0.928,"HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0333890133180656,0.0324520237811379,FALSE
+"HCC827","Pearson.est","potassium channel blocker",-0.22232,-0.55,0.96,1074,0.988,"ibutilide, meglitinide",0.0177287669604316,0.00524305541237188,FALSE
+"HCC827","Pearson.est","PPAR receptor agonist",-0.36223,-0.882,0.617,1305,0.852,"pterostilbene",0.209714835966758,0.0695604052332999,FALSE
+"HCC827","Pearson.est","progesterone receptor agonist",-0.38876,-0.945,0.522,1341,0.776,"melengestrol.acetate, danazol",0.282329496997738,0.110138278741812,FALSE
+"HCC827","Pearson.est","proteasome inhibitor",0.39024,1.11,0.299,104,0.754,"MG.132, carfilzomib",0.52432881167557,0.122628654130226,FALSE
+"HCC827","Pearson.est","protein synthesis inhibitor",0.34201,0.936,0.531,151,1,"homoharringtonine, cycloheximide, clofoctol, bruceantin, anguidine, chloramphenicol.palmitate",0.274905478918531,0,FALSE
+"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.31799,-0.765,0.746,628,0.843,"PP.121, tyrphostin.A9, CP.724714, rheochrysidin, mubritinib, NVP.TAE226, BMS.599626",0.127261172527331,0.0741724253752577,FALSE
+"HCC827","Pearson.est","RAF inhibitor",0.29939,0.863,0.615,76,1,"vemurafenib, AZ.628, LGX818",0.211124884224583,0,FALSE
+"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.33619,-0.821,0.702,1041,0.827,"sunitinib, cabozantinib, sorafenib",0.153662887870195,0.0824944904474534,FALSE
+"HCC827","Pearson.est","retinoid receptor agonist",-0.50995,-1.21,0.246,1242,0.635,"adapalene, fenretinide, bexarotene",0.609064892896621,0.197226274708024,FALSE
+"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.32612,-0.789,0.725,882,0.856,"clofarabine, cytarabine, fludarabine, cladribine, pentostatin",0.139661993429006,0.0675262353228468,FALSE
+"HCC827","Pearson.est","serotonin receptor agonist",-0.57104,-1.38,0.121,1244,0.541,"ipsapirone, aripiprazole",0.91721462968355,0.266802734893431,FALSE
+"HCC827","Pearson.est","serotonin receptor antagonist",-0.47928,-1.16,0.299,1168,0.701,"paliperidone, lurasidone, aripiprazole",0.52432881167557,0.154281982033341,FALSE
+"HCC827","Pearson.est","sodium channel blocker",-0.46433,-1.14,0.309,976,0.696,"oxcarbazepine, cibenzoline, A.803467, triamterene, ajmaline, quinidine, lappaconite",0.510041520575165,0.157390760389438,FALSE
+"HCC827","Pearson.est","src inhibitor",-0.40403,-0.972,0.484,1185,0.803,"KX2.391, PP.1, masitinib",0.315154638355588,0.095284454721319,FALSE
+"HCC827","Pearson.est","sterol demethylase inhibitor",-0.61435,-1.47,0.0696,1174,0.888,"terconazole, ketoconazole",1.15739076038944,0.051587034221399,FALSE
+"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.34185,-0.84,0.671,1375,0.848,"adaprev",0.173277479831008,0.0716041477432862,FALSE
+"HCC827","Pearson.est","thymidylate synthase inhibitor",0.41914,1.16,0.273,113,0.727,"capecitabine, doxifluridine",0.563837352959244,0.138465589140962,FALSE
+"HCC827","Pearson.est","topoisomerase inhibitor",-0.30184,-0.732,0.794,849,0.854,"valrubicin, etoposide.phosphate, topotecan, voreloxin, nemorubicin, camptothecin, SN.38, TAS.103, rubitecan, fleroxacin, genz.644282, dexrazoxane, irinotecan",0.100179497572904,0.068542129310995,FALSE
+"HCC827","Pearson.est","tubulin polymerization inhibitor",0.2799,0.818,0.654,384,0.856,"mebendazole, CYT.997, BNC105, paclitaxel, vindesine, vincristine, epothilone.b, fenbendazole, taltobulin, verubulin, dolastatin.10, vinblastine, vinorelbine, oxibendazole, podophyllotoxin, fosbretabulin",0.184422251675733,0.0675262353228468,FALSE
+"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.21299,-0.518,0.971,1035,0.987,"NVP.TAE226, sunitinib, cabozantinib, sorafenib, GTP.14564, BMS.599626, UNC2250",0.0127807700919951,0.00568284733036327,FALSE
+"HCC827","Pearson.est","VEGFR inhibitor",-0.35564,-0.875,0.639,1018,0.845,"RAF265, sunitinib, orantinib, linifanib, PD.173074, cabozantinib, axitinib, ENMD.2076, sorafenib, lenvatinib, MK.2461, MGCD.265, lucitanib, tivozanib, KI.8751",0.1944991418416,0.0731432910503077,FALSE
+"HCC827","Pearson.est","vitamin D receptor agonist",-0.57307,-1.41,0.0948,1260,0.611,"maxacalcitol, paricalcitol, tacalcitol",1.02319166266193,0.213958789757446,FALSE
+"CALU3","Pearson.est","EGFR inhibitor",0.38803,1.04,0.361,197,0.674,"pelitinib, canertinib, erlotinib, afatinib, brigatinib, XL.647, rociletinib, BMS.690514, vandetanib, PD.168393, poziotinib, AZD8931, neratinib, dacomitinib",0.442492798094342,0.17134010346468,FALSE
+"CALU3","Pearson.est","Abl kinase inhibitor",-0.49386,-1.19,0.253,1064,0.687,"metatinib, nilotinib, flumatinib, KW.2449, imatinib, ponatinib, tozasertib",0.596879478824182,0.16304326294045,FALSE
+"CALU3","Pearson.est","acetylcholine receptor agonist",-0.41186,-0.993,0.471,1112,0.713,"nicotine, nefiracetam, pilocarpine",0.326979092871104,0.146910470148134,FALSE
+"CALU3","Pearson.est","acetylcholine receptor antagonist",-0.5596,-1.38,0.118,1035,0.445,"dicycloverine, iododexetimide, methscopolamine",0.928117992693875,0.351639989019068,FALSE
+"CALU3","Pearson.est","adenosine receptor antagonist",-0.56199,-1.38,0.127,1213,0.445,"MRS.1220, CGS.15943, SCH.58261",0.896196279044043,0.351639989019068,FALSE
+"CALU3","Pearson.est","adrenergic receptor agonist",-0.45512,-1.13,0.31,1141,0.637,"metaraminol, isoxsuprine, clenbuterol, isoetharine, norepinephrine, buphenine",0.508638306165727,0.19586056766465,FALSE
+"CALU3","Pearson.est","adrenergic receptor antagonist",0.45011,1.24,0.196,281,0.756,"prazosin, vincamine, RS.17053, imiloxan, levobunolol, dihydroergocristine, idazoxan, atenolol...., practolol",0.707743928643524,0.121478204498793,FALSE
+"CALU3","Pearson.est","AKT inhibitor",-0.48269,-1.22,0.229,1134,0.648,"triciribine, ONC201, CCT128930, uprosertib, A.674563",0.640164517660112,0.188424994129407,FALSE
+"CALU3","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.2247,-0.551,0.946,983,0.971,"AZD3463, AP26113, CEP.37440, alectinib, DMH1",0.0241088635982073,0.0127807700919951,FALSE
+"CALU3","Pearson.est","androgen receptor antagonist",-0.45809,-1.14,0.305,687,0.717,"cyproterone.acetate, RU.58841, nilutamide, flutamide, bicalutamide",0.515700160653214,0.1444808443322,FALSE
+"CALU3","Pearson.est","antioxidant",-0.45616,-1.11,0.339,1307,0.633,"benfotiamine, trolox",0.469800301796918,0.198596289982645,FALSE
+"CALU3","Pearson.est","AP inhibitor",0.74371,1.99,0.0134,30,0.242,"GDC.0152, birinapant",1.87289520163519,0.616184634019569,TRUE
+"CALU3","Pearson.est","ATPase inhibitor",0.37978,1.07,0.372,121,0.727,"k.strophanthidin, digitoxin, ouabain",0.429457060118102,0.138465589140962,FALSE
+"CALU3","Pearson.est","Aurora kinase inhibitor",-0.56645,-1.42,0.107,1048,0.494,"CCT129202, CCT137690, AT.9283, SNS.314, MK.8745, AMG900, ENMD.2076, PF.03814735, KW.2449, aurora.a.inhibitor.i, barasertib, hesperadin, tozasertib",0.97061622231479,0.306273051076353,FALSE
+"CALU3","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.57026,-1.42,0.0977,855,0.494,"azalomycin.b, josamycin, tilmicosin, azithromycin, valnemulin, radezolid, dirithromycin",1.01010543628123,0.306273051076353,FALSE
+"CALU3","Pearson.est","bacterial DNA gyrase inhibitor",0.49922,1.35,0.164,412,0.626,"finafloxacin, sarafloxacin, novobiocin, lomefloxacin, sparfloxacin, trovafloxacin, norfloxacin",0.785156151952302,0.20342566678957,FALSE
+"CALU3","Pearson.est","BCL inhibitor",-0.45702,-1.13,0.317,1261,0.637,"ABT.737, gossypol",0.498940737782249,0.19586056766465,FALSE
+"CALU3","Pearson.est","Bcr.Abl kinase inhibitor",-0.49183,-1.22,0.236,1064,0.648,"metatinib, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.627087997029893,0.188424994129407,FALSE
+"CALU3","Pearson.est","benzodiazepine receptor agonist",0.28464,0.773,0.754,35,0.904,"ZK.93423, gamma.aminobutyric.acid",0.122628654130226,0.0438315695246367,FALSE
+"CALU3","Pearson.est","bromodomain inhibitor",-0.63522,-1.57,0.0542,1154,0.642,"PFI.1, JQ1...., I.BET151, bromosporine",1.26600071346161,0.192464971931147,FALSE
+"CALU3","Pearson.est","calcium channel blocker",-0.55072,-1.36,0.142,1249,0.459,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.847711655616944,0.338187314462739,FALSE
+"CALU3","Pearson.est","CC chemokine receptor antagonist",-0.4822,-1.18,0.277,868,0.652,"RS.504393, SB.225002, PF.04136309, navarixin",0.557520230935551,0.18575240426808,FALSE
+"CALU3","Pearson.est","CDK inhibitor",-0.43302,-1.06,0.405,1071,0.649,"JNJ.7706621, BMS.265246, palbociclib, AZD5438, ribociclib, abemaciclib, NU6027, kenpaullone, R547, indirubin, arcyriaflavin.a",0.392544976785331,0.187755303199631,FALSE
+"CALU3","Pearson.est","CHK inhibitor",0.53167,1.43,0.115,294,0.576,"SCH.900776, CHIR.124, LY2603618, PF.477736, LY2606368, AZD7762",0.939302159646388,0.239577516576788,FALSE
+"CALU3","Pearson.est","cyclooxygenase inhibitor",-0.30451,-0.747,0.764,1011,0.848,"piroxicam, naproxen, curcumin, indoprofen, aspirin, tepoxalin, pterostilbene, FR.122047, tryptanthrin",0.11690664142431,0.0716041477432862,FALSE
+"CALU3","Pearson.est","cytochrome P450 inhibitor",0.40775,1.16,0.238,312,0.616,"PF.4981517, morin, eplerenone, metyrapone",0.623423042943488,0.210419287835575,FALSE
+"CALU3","Pearson.est","DNA alkylating agent",-0.35887,-0.875,0.601,804,0.776,"streptozotocin, carboplatin, temozolomide, cisplatin, ifosfamide, cyclophosphamide, carmustine, satraplatin, melphalan, mitomycin.c",0.22112552799726,0.110138278741812,FALSE
+"CALU3","Pearson.est","DNA inhibitor",-0.38627,-0.955,0.505,1150,0.726,"carmustine, pibenzimol, primaquine, mechlorethamine, metronidazole, melphalan",0.296708621881339,0.139063379299906,FALSE
+"CALU3","Pearson.est","DNA methyltransferase inhibitor",-0.28908,-0.724,0.811,1194,0.846,"disulfiram, RG108",0.090979145788844,0.0726296369609765,FALSE
+"CALU3","Pearson.est","DNA polymerase inhibitor",0.21157,0.576,0.941,313,0.981,"cephalomannine, famciclovir, menadione",0.0264103765727431,0.0083309926200515,FALSE
+"CALU3","Pearson.est","DNA synthesis inhibitor",-0.36752,-0.923,0.535,908,0.731,"azodicarbonamide, cisplatin, anisomycin, estramustine.phosphate, CB.10.277, artesunate, enocitabine, mitomycin.c",0.271646217978772,0.13608262304214,FALSE
+"CALU3","Pearson.est","dopamine receptor antagonist",-0.39384,-0.965,0.488,1227,0.726,"paliperidone, nemonapride, lurasidone, mesoridazine",0.311580177997289,0.139063379299906,FALSE
+"CALU3","Pearson.est","estrogen receptor agonist",0.43255,1.18,0.275,267,0.635,"levonorgestrel, PPT, ethinyl.estradiol, erteberel",0.560667306169737,0.197226274708024,FALSE
+"CALU3","Pearson.est","estrogen receptor antagonist",-0.70105,-1.72,0.0157,1270,0.454,"toremifene, danazol, fulvestrant",1.80410034759077,0.342944147142896,FALSE
+"CALU3","Pearson.est","FGFR inhibitor",-0.60473,-1.49,0.0699,984,0.69,"regorafenib, orantinib, PD.173074, lenvatinib, MK.2461, lucitanib, erdafitinib",1.15552282425432,0.161150909262745,FALSE
+"CALU3","Pearson.est","FLT3 inhibitor",-0.64927,-1.57,0.0228,1124,0.642,"pacritinib, tandutinib, sunitinib, TG.101348, GTP.14564, ENMD.2076, KW.2449, sorafenib, quizartinib, ponatinib, tozasertib",1.64206515299955,0.192464971931147,FALSE
+"CALU3","Pearson.est","glucocorticoid receptor agonist",0.5931,1.65,0.0605,278,0.434,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, halcinonide, fluocinolone.acetonide, prednisolone, ciclesonide, triamcinolone.acetonide, fludroxycortide, desonide, dexamethasone.acetate",1.21824462534753,0.362510270487489,FALSE
+"CALU3","Pearson.est","glutamate receptor antagonist",0.38391,1.05,0.363,234,0.707,"SIB.1757, latrepirdine, kynurenic.acid, CPP, CGP.37849",0.440093374963888,0.150580586203101,FALSE
+"CALU3","Pearson.est","glycogen synthase kinase inhibitor",-0.59869,-1.49,0.0715,1262,0.69,"LY2090314, CHIR.98014, GSK.3.inhibitor.IX, kenpaullone, indirubin",1.14569395819892,0.161150909262745,FALSE
+"CALU3","Pearson.est","growth factor receptor inhibitor",-0.43489,-1.06,0.382,842,0.649,"lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.417936637088291,0.187755303199631,FALSE
+"CALU3","Pearson.est","HCV inhibitor",0.25798,0.706,0.85,1076,0.92,"daclatasvir, mericitabine, embelin, PSI.7976, Ro.9187, narlaprevir",0.0705810742857073,0.0362121726544447,FALSE
+"CALU3","Pearson.est","HDAC inhibitor",-0.58982,-1.46,0.081,1097,0.605,"PCI.24781, scriptaid, dacinostat, entinostat, panobinostat, trichostatin.a, AR.42, vorinostat, givinostat, RGFP966, RG2833, R306465, M.344, resminostat",1.09151498112135,0.218244625347531,FALSE
+"CALU3","Pearson.est","histamine receptor antagonist",-0.34977,-0.843,0.659,1103,0.761,"tecastemizole, cyproheptadine, BF2.649, lafutidine, epinastine",0.18111458540599,0.118615343229427,FALSE
+"CALU3","Pearson.est","HMGCR inhibitor",-0.20101,-0.496,0.98,1180,0.979,"lovastatin",0.00877392430750515,0.00921730819686218,FALSE
+"CALU3","Pearson.est","HSP inhibitor",0.53638,1.55,0.0631,201,0.476,"KW.2478, BIIB021, alvespimycin, SNX.2112, SNX.5422",1.19997064075587,0.322393047279507,FALSE
+"CALU3","Pearson.est","JAK inhibitor",-0.34936,-0.874,0.637,1124,0.761,"pacritinib, AT.9283, TG.101348, TG.101209, tozasertib",0.19586056766465,0.118615343229427,FALSE
+"CALU3","Pearson.est","KIT inhibitor",-0.46928,-1.13,0.311,1128,0.637,"telatinib, tandutinib, lenvatinib, sunitinib, imatinib, sorafenib, KI.8751, masitinib",0.507239610973163,0.19586056766465,FALSE
+"CALU3","Pearson.est","MDM inhibitor",-0.47381,-1.18,0.284,1164,0.652,"serdemetan, RITA",0.546681659952962,0.18575240426808,FALSE
+"CALU3","Pearson.est","MEK inhibitor",0.60038,1.65,0.0465,181,0.434,"Ro.4987655, selumetinib, AS.703026, trametinib, MEK1.2.inhibitor, TAK.733, PD.198306, AZD8330, PD.0325901, cobimetinib",1.33254704711005,0.362510270487489,FALSE
+"CALU3","Pearson.est","MET inhibitor",-0.74291,-1.82,0.0102,1414,0.396,"NVP.BVU972, AMG458",1.99139982823808,0.402304814074488,FALSE
+"CALU3","Pearson.est","microtubule inhibitor",0.22457,0.632,0.894,347,0.973,"secnidazole, triclabendazole, vinblastine, vinflunine",0.0486624812040823,0.0118871597316481,FALSE
+"CALU3","Pearson.est","mTOR inhibitor",-0.48596,-1.22,0.249,930,0.648,"GDC.0980, WYE.125132, temsirolimus, NVP.BEZ235, torin.2, LY303511, PF.04691502, XL388, sirolimus, MLN0128, torin.1, LY3023414, GSK2126458, ku.0063794, AZD2014, WYE.354, SB.2343",0.603800652904264,0.188424994129407,FALSE
+"CALU3","Pearson.est","NFkB pathway inhibitor",-0.3587,-0.872,0.621,1338,0.749,"EVP4593, betulinic.acid",0.20690839982342,0.125518182300534,FALSE
+"CALU3","Pearson.est","opioid receptor agonist",-0.30449,-0.735,0.779,766,0.848,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.108462542327436,0.0716041477432862,FALSE
+"CALU3","Pearson.est","p38 MAPK inhibitor",-0.39915,-0.988,0.477,1277,0.703,"SB.239063, skepinone.l",0.321481620959886,0.153044674980176,FALSE
+"CALU3","Pearson.est","PARP inhibitor",-0.56085,-1.38,0.125,1286,0.445,"PJ.34, niraparib, E7449",0.903089986991944,0.351639989019068,FALSE
+"CALU3","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.52698,-1.3,0.165,1128,0.554,"telatinib, axitinib, tandutinib, crenolanib, linifanib, lenvatinib, sunitinib, imatinib, sorafenib, ponatinib, KI.8751, masitinib",0.782516055786094,0.25649023527157,FALSE
+"CALU3","Pearson.est","phosphatase inhibitor",-0.45414,-1.12,0.302,987,0.634,"bis.maltolato.oxovanadium.IV., CID.5458317, BVT.948, alexidine, GSK2830371",0.519993057042849,0.197910742118267,FALSE
+"CALU3","Pearson.est","phosphodiesterase inhibitor",0.2694,0.73,0.782,166,0.928,"cilostamide, EMD.53998",0.106793246940152,0.0324520237811379,FALSE
+"CALU3","Pearson.est","PI3K inhibitor",-0.42574,-1.03,0.416,930,0.685,"GDC.0980, TG.100713, NVP.BEZ235, LY303511, BGT226, TG100.115, PF.04691502, PI3K.IN.2, LY3023414, GDC.0941, GSK2126458, CUDC.907, CH5132799, SB.2343",0.380906669373257,0.164309428507574,FALSE
+"CALU3","Pearson.est","PLK inhibitor",0.20958,0.57,0.951,1146,0.946,"HMN.214, NMS.1286937, BI.2536, GSK461364, volasertib, rigosertib, GW.843682X",0.0218194830625861,0.0241088635982073,FALSE
+"CALU3","Pearson.est","potassium channel blocker",0.33773,0.92,0.493,961,0.687,"dofetilide, mepivacaine, oleoylethanolamide, meglitinide, ML133, ibutilide",0.30715308072277,0.16304326294045,FALSE
+"CALU3","Pearson.est","PPAR receptor agonist",-0.38488,-0.935,0.528,1300,0.728,"pterostilbene",0.277366077466188,0.137868620686963,FALSE
+"CALU3","Pearson.est","progesterone receptor agonist",-0.32306,-0.8,0.707,1310,0.793,"melengestrol.acetate, danazol",0.150580586203101,0.100726812682396,FALSE
+"CALU3","Pearson.est","proteasome inhibitor",0.37456,1.01,0.384,154,0.604,"MG.132, carfilzomib",0.415668775632469,0.218963061378868,FALSE
+"CALU3","Pearson.est","protein synthesis inhibitor",0.36332,1.03,0.419,111,0.648,"cycloheximide, clofoctol, bruceantin, chloramphenicol.palmitate, puromycin, homoharringtonine",0.377785977033705,0.188424994129407,FALSE
+"CALU3","Pearson.est","protein tyrosine kinase inhibitor",-0.41779,-1.02,0.441,933,0.685,"tyrphostin.A9, NVP.TAE226, mubritinib, BMS.599626",0.355561410532161,0.164309428507574,FALSE
+"CALU3","Pearson.est","RAF inhibitor",-0.34395,-0.853,0.648,1366,0.762,"sorafenib, TAK.632",0.188424994129407,0.1180450286604,FALSE
+"CALU3","Pearson.est","RET tyrosine kinase inhibitor",-0.44483,-1.08,0.366,984,0.65,"regorafenib, cabozantinib, sunitinib, sorafenib",0.436518914605589,0.187086643357144,FALSE
+"CALU3","Pearson.est","retinoid receptor agonist",-0.59488,-1.47,0.0745,1321,0.659,"adapalene, bexarotene, fenretinide",1.12784372725171,0.18111458540599,FALSE
+"CALU3","Pearson.est","ribonucleotide reductase inhibitor",-0.38244,-0.95,0.514,844,0.718,"cytarabine, hydroxyurea, clofarabine, fludarabine, cladribine, pentostatin",0.289036881004724,0.1438755557577,FALSE
+"CALU3","Pearson.est","serotonin receptor agonist",-0.56637,-1.41,0.117,1095,0.478,"NAN.190, ipsapirone, aripiprazole",0.931814138253838,0.320572103387881,FALSE
+"CALU3","Pearson.est","serotonin receptor antagonist",-0.45977,-1.13,0.336,1227,0.637,"paliperidone, lurasidone, aripiprazole",0.473660722610156,0.19586056766465,FALSE
+"CALU3","Pearson.est","sodium channel blocker",-0.45013,-1.08,0.366,1272,0.65,"quinidine, triamterene, lappaconite, ajmaline",0.436518914605589,0.187086643357144,FALSE
+"CALU3","Pearson.est","src inhibitor",0.35567,0.973,0.438,27,0.631,"saracatinib, dasatinib",0.3585258894959,0.199970640755866,FALSE
+"CALU3","Pearson.est","sterol demethylase inhibitor",-0.58389,-1.43,0.0946,1053,0.563,"terconazole, ketoconazole",1.02410886359821,0.249491605148654,FALSE
+"CALU3","Pearson.est","TGF beta receptor inhibitor",0.36657,1.02,0.415,110,0.625,"repsox, SB.525334",0.381951903287907,0.204119982655925,FALSE
+"CALU3","Pearson.est","thymidylate synthase inhibitor",0.41215,1.21,0.221,241,0.727,"capecitabine, doxifluridine, ftorafur",0.655607726314889,0.138465589140962,FALSE
+"CALU3","Pearson.est","topoisomerase inhibitor",-0.33262,-0.809,0.71,1005,0.796,"etoposide.phosphate, TAS.103, SN.38, topotecan, nemorubicin, fleroxacin, dexrazoxane, genz.644282, rubitecan, irinotecan",0.148741651280925,0.0990869322623309,FALSE
+"CALU3","Pearson.est","tubulin polymerization inhibitor",0.41293,1.18,0.254,353,0.635,"mebendazole, CYT.997, vincristine, paclitaxel, BNC105, epothilone.b, vindesine, verubulin, vinorelbine, dolastatin.10, vinblastine, oxibendazole",0.595166283380062,0.197226274708024,FALSE
+"CALU3","Pearson.est","tyrosine kinase inhibitor",-0.29472,-0.711,0.806,904,0.846,"bafetinib, tyrphostin.A9, regorafenib, NVP.TAE226, cabozantinib, mubritinib, BMS.599626, sunitinib, GTP.14564, UNC2250, sorafenib",0.0936649581949093,0.0726296369609765,FALSE
+"CALU3","Pearson.est","VEGFR inhibitor",-0.37757,-0.917,0.563,1019,0.725,"orantinib, foretinib, RAF265, cabozantinib, telatinib, PD.173074, axitinib, linifanib, lenvatinib, sunitinib, ENMD.2076, MK.2461, MGCD.265, lucitanib, sorafenib, tivozanib, KI.8751",0.249491605148654,0.139661993429006,FALSE
+"CALU3","Pearson.est","vitamin D receptor agonist",-0.58269,-1.43,0.106,1288,0.563,"maxacalcitol, paricalcitol, tacalcitol",0.97469413473523,0.249491605148654,FALSE
+"H2009","Pearson.est","EGFR inhibitor",0.33711,0.951,0.502,71,0.97,"pelitinib, canertinib, brigatinib, erlotinib, vandetanib, BMS.690514, rociletinib, XL.647, afatinib",0.299296282854981,0.0132282657337552,FALSE
+"H2009","Pearson.est","Abl kinase inhibitor",-0.45177,-1.09,0.363,1087,0.814,"flumatinib, nilotinib, imatinib, KW.2449, ponatinib, tozasertib",0.440093374963888,0.0893755951107988,FALSE
+"H2009","Pearson.est","acetylcholine receptor agonist",-0.43452,-1.06,0.404,1141,0.729,"nicotine, nefiracetam, pilocarpine",0.393618634889395,0.137272471682025,FALSE
+"H2009","Pearson.est","acetylcholine receptor antagonist",-0.52396,-1.26,0.195,882,0.57,"diphemanil, dicycloverine, iododexetimide, methscopolamine",0.709965388637482,0.244125144327509,FALSE
+"H2009","Pearson.est","adenosine receptor antagonist",-0.54367,-1.34,0.145,1178,0.601,"MRS.1220, CGS.15943, SCH.58261",0.838631997765025,0.22112552799726,FALSE
+"H2009","Pearson.est","adrenergic receptor agonist",-0.42098,-1.02,0.446,1050,0.71,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.350665141287858,0.148741651280925,FALSE
+"H2009","Pearson.est","adrenergic receptor antagonist",0.43772,1.25,0.233,217,0.633,"prazosin, vincamine, RS.17053, practolol, imiloxan, levobunolol, atenolol...., dihydroergocristine, idazoxan",0.632644078973981,0.198596289982645,FALSE
+"H2009","Pearson.est","AKT inhibitor",-0.53931,-1.3,0.157,1168,0.594,"triciribine, ONC201, CCT128930, uprosertib, A.674563",0.804100347590766,0.226213555018806,FALSE
+"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27959,-0.684,0.869,1007,0.896,"AZD3463, CEP.37440, AP26113, alectinib, DMH1",0.0609802235513335,0.0476919903378748,FALSE
+"H2009","Pearson.est","androgen receptor antagonist",-0.54501,-1.29,0.172,946,0.557,"nilutamide, flutamide, bicalutamide",0.764471553092451,0.254144804826271,FALSE
+"H2009","Pearson.est","antioxidant",-0.4472,-1.07,0.385,1273,0.779,"benfotiamine, trolox",0.414539270491499,0.108462542327436,FALSE
+"H2009","Pearson.est","AP inhibitor",0.60406,1.8,0.039,32,0.292,"GDC.0152, birinapant",1.4089353929735,0.534617148551582,FALSE
+"H2009","Pearson.est","ATPase inhibitor",0.30959,0.884,0.55,205,0.845,"k.strophanthidin, digitoxin, ouabain, blebbistatin....",0.259637310505756,0.0731432910503077,FALSE
+"H2009","Pearson.est","Aurora kinase inhibitor",-0.62806,-1.55,0.0389,1097,0.69,"CCT129202, CCT137690, barasertib.HQPA, KW.2449, aurora.a.inhibitor.i, AMG900, AT.9283, MK.8745, ENMD.2076, SNS.314, PF.03814735, barasertib, hesperadin, tozasertib",1.41005039867429,0.161150909262745,FALSE
+"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.63497,-1.53,0.0538,921,0.623,"valnemulin, azalomycin.b, azithromycin, josamycin, tilmicosin, radezolid, dirithromycin",1.26921772433361,0.20551195334083,FALSE
+"H2009","Pearson.est","bacterial DNA gyrase inhibitor",0.4705,1.27,0.212,138,0.69,"finafloxacin, sarafloxacin, novobiocin",0.673664139071249,0.161150909262745,FALSE
+"H2009","Pearson.est","BCL inhibitor",-0.54946,-1.34,0.139,1294,0.601,"gossypol, ABT.737",0.856985199745905,0.22112552799726,FALSE
+"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.42968,-1.03,0.427,1087,0.728,"flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.369572124974976,0.137868620686963,FALSE
+"H2009","Pearson.est","benzodiazepine receptor agonist",0.23563,0.698,0.819,37,0.961,"gamma.aminobutyric.acid, ZK.93423",0.0867160982395816,0.0172766123314547,FALSE
+"H2009","Pearson.est","bromodomain inhibitor",-0.76289,-1.83,0.0013,1108,0.314,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.88605664769316,0.503070351926785,FALSE
+"H2009","Pearson.est","calcium channel blocker",-0.6204,-1.49,0.0575,1249,0.557,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.24033215531037,0.254144804826271,FALSE
+"H2009","Pearson.est","CC chemokine receptor antagonist",-0.52495,-1.25,0.208,1046,0.542,"SB.225002, PF.04136309, navarixin",0.681936665037238,0.266000713461613,FALSE
+"H2009","Pearson.est","CDK inhibitor",-0.5256,-1.29,0.181,1014,0.557,"palbociclib, AZD5438, TG.02, BMS.265246, JNJ.7706621, NU6027, indisulam, ribociclib, abemaciclib, kenpaullone, indirubin, R547, arcyriaflavin.a",0.742321425130815,0.254144804826271,FALSE
+"H2009","Pearson.est","CHK inhibitor",0.4894,1.45,0.105,318,0.728,"SCH.900776, CHIR.124, LY2603618, LY2606368, PF.477736, AZD7762",0.978810700930062,0.137868620686963,FALSE
+"H2009","Pearson.est","cyclooxygenase inhibitor",-0.3088,-0.744,0.787,881,0.858,"metoxibutropate, meloxicam, FK.3311, curcumin, indoprofen, piroxicam, tepoxalin, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.104025267640935,0.0665127121512946,FALSE
+"H2009","Pearson.est","cytochrome P450 inhibitor",0.40522,1.14,0.301,250,0.688,"PF.4981517, morin, eplerenone, metyrapone",0.521433504406157,0.162411561764489,FALSE
+"H2009","Pearson.est","DNA alkylating agent",-0.35278,-0.864,0.633,778,0.781,"streptozotocin, cisplatin, temozolomide, carboplatin, ifosfamide, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.198596289982645,0.1073489661227,FALSE
+"H2009","Pearson.est","DNA inhibitor",-0.35593,-0.874,0.616,998,0.797,"tirapazamine, carmustine, metronidazole, pibenzimol, primaquine, mechlorethamine, melphalan",0.210419287835575,0.0985416786038876,FALSE
+"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.38696,-0.951,0.544,1042,0.827,"fdcyd, RG108, disulfiram",0.26440110030182,0.0824944904474534,FALSE
+"H2009","Pearson.est","DNA polymerase inhibitor",0.28542,0.789,0.749,1037,0.919,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, cidofovir, trifluridine, foscarnet",0.125518182300534,0.0366844886138887,FALSE
+"H2009","Pearson.est","DNA synthesis inhibitor",-0.31715,-0.772,0.752,854,0.868,"artesunate, anisomycin, azodicarbonamide, estramustine.phosphate, altretamine, CB.10.277, enocitabine, mitomycin.c",0.123782159408358,0.0614802748235081,FALSE
+"H2009","Pearson.est","dopamine receptor antagonist",-0.38244,-0.926,0.56,1091,0.794,"UH.232...., nemonapride, paliperidone, lurasidone, mesoridazine",0.2518119729938,0.100179497572904,FALSE
+"H2009","Pearson.est","estrogen receptor agonist",0.4742,1.35,0.142,46,0.782,"PPT, levonorgestrel",0.847711655616944,0.106793246940152,FALSE
+"H2009","Pearson.est","estrogen receptor antagonist",-0.66459,-1.62,0.0286,1276,0.875,"toremifene, danazol, fulvestrant",1.54363396687096,0.0579919469776868,FALSE
+"H2009","Pearson.est","FGFR inhibitor",-0.57235,-1.39,0.104,894,0.606,"regorafenib, orantinib, PD.173074, lenvatinib, MK.2461, erdafitinib, lucitanib",0.98296666070122,0.217527375833714,FALSE
+"H2009","Pearson.est","FLT3 inhibitor",-0.61228,-1.47,0.0796,1024,0.547,"TG.02, pacritinib, sunitinib, GTP.14564, KW.2449, tandutinib, TG.101348, ENMD.2076, ponatinib, sorafenib, quizartinib, tozasertib",1.09908693226233,0.262012673666569,FALSE
+"H2009","Pearson.est","glucocorticoid receptor agonist",0.45798,1.3,0.154,291,0.751,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, ciclesonide, halcinonide, fludroxycortide, prednisolone, desonide, triamcinolone.acetonide",0.812479279163537,0.124360062995832,FALSE
+"H2009","Pearson.est","glutamate receptor antagonist",0.33489,0.926,0.485,283,0.874,"SIB.1757, latrepirdine, kynurenic.acid, CGP.37849, CPP, JNJ.16259685",0.314258261397736,0.058488567365597,FALSE
+"H2009","Pearson.est","glycogen synthase kinase inhibitor",-0.54172,-1.33,0.155,1209,0.55,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, CHIR.98014, indirubin",0.809668301829709,0.259637310505756,FALSE
+"H2009","Pearson.est","growth factor receptor inhibitor",-0.47638,-1.16,0.284,904,0.696,"lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.546681659952962,0.157390760389438,FALSE
+"H2009","Pearson.est","HCV inhibitor",-0.21592,-0.52,0.963,1262,0.986,"narlaprevir",0.0163737128754655,0.0061230850587888,FALSE
+"H2009","Pearson.est","HDAC inhibitor",-0.55568,-1.33,0.14,1040,0.55,"scriptaid, PCI.24781, entinostat, dacinostat, panobinostat, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.853871964321762,0.259637310505756,FALSE
+"H2009","Pearson.est","histamine receptor antagonist",-0.31257,-0.755,0.766,1063,0.859,"cyproheptadine, tecastemizole, BF2.649, lafutidine, epinastine",0.115771230367396,0.0660068361687577,FALSE
+"H2009","Pearson.est","HMGCR inhibitor",0.24827,0.697,0.845,1090,0.914,"pitavastatin, simvastatin, mevastatin, atorvastatin, fluvastatin, lovastatin",0.0731432910503077,0.0390538042661686,FALSE
+"H2009","Pearson.est","HSP inhibitor",0.42702,1.22,0.245,324,0.608,"BIIB021, KW.2478, SNX.2112, alvespimycin, SNX.5422, VER.49009, NVP.AUY922",0.610833915635468,0.216096420727265,FALSE
+"H2009","Pearson.est","JAK inhibitor",-0.38101,-0.917,0.59,876,0.792,"CEP.33779, lestaurtinib, LY2784544, TG.02, pacritinib, AZD1480, TG.101348, AT.9283, TG.101209, tozasertib",0.229147988357856,0.101274818410506,FALSE
+"H2009","Pearson.est","KIT inhibitor",-0.43848,-1.06,0.387,1149,0.729,"sunitinib, imatinib, lenvatinib, tandutinib, sorafenib, KI.8751, masitinib",0.412289034981089,0.137272471682025,FALSE
+"H2009","Pearson.est","MDM inhibitor",-0.43514,-1.06,0.394,1177,0.729,"serdemetan, RITA",0.404503778174426,0.137272471682025,FALSE
+"H2009","Pearson.est","MEK inhibitor",0.63625,1.81,0.0224,161,0.557,"selumetinib, trametinib, AS.703026, MEK1.2.inhibitor, Ro.4987655, TAK.733, AZD8330, cobimetinib, PD.198306, PD.0325901",1.64975198166584,0.254144804826271,FALSE
+"H2009","Pearson.est","MET inhibitor",-0.65206,-1.58,0.0333,1411,0.762,"NVP.BVU972, AMG458",1.47755576649368,0.1180450286604,FALSE
+"H2009","Pearson.est","microtubule inhibitor",-0.20399,-0.495,0.972,1304,0.979,"D.64131",0.0123337350737254,0.00921730819686218,FALSE
+"H2009","Pearson.est","mTOR inhibitor",-0.44505,-1.08,0.368,700,0.809,"deforolimus, AZD8055, PF.05212384, NVP.BEZ235, PKI.179, GDC.0980, temsirolimus, WYE.125132, OSI.027, voxtalisib, MLN0128, torin.2, sirolimus, LY303511, XL388, torin.1, LY3023414, PF.04691502, GSK2126458, WYE.354, ku.0063794, AZD2014, SB.2343",0.434152181326482,0.0920514783877277,FALSE
+"H2009","Pearson.est","NFkB pathway inhibitor",-0.33387,-0.805,0.719,1330,0.837,"EVP4593, betulinic.acid",0.143271109617117,0.07727454200674,FALSE
+"H2009","Pearson.est","opioid receptor agonist",-0.38969,-0.946,0.543,820,0.816,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.265200170411153,0.0883098412461389,FALSE
+"H2009","Pearson.est","p38 MAPK inhibitor",-0.44491,-1.07,0.375,1338,0.779,"SB.239063, skepinone.l",0.425968732272281,0.108462542327436,FALSE
+"H2009","Pearson.est","PARP inhibitor",-0.59784,-1.44,0.0731,1122,0.513,"AG.14361, PJ.34, E7449, niraparib",1.13608262304214,0.289882634888184,FALSE
+"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.47729,-1.17,0.278,1100,0.699,"axitinib, linifanib, crenolanib, sunitinib, imatinib, lenvatinib, tandutinib, ponatinib, sorafenib, KI.8751, masitinib",0.555955204081924,0.155522824254319,FALSE
+"H2009","Pearson.est","phosphatase inhibitor",-0.42714,-1.04,0.423,698,0.729,"bis.maltolato.oxovanadium.IV., sodium.stibogluconate, mycophenolic.acid, AS.1949490, BVT.948, CID.5458317, alexidine, GSK2830371",0.373659632624958,0.137272471682025,FALSE
+"H2009","Pearson.est","phosphodiesterase inhibitor",0.21912,0.647,0.9,148,0.929,"cilostamide, EMD.53998",0.0457574905606751,0.0319842860063582,FALSE
+"H2009","Pearson.est","PI3K inhibitor",-0.42772,-1.04,0.419,730,0.729,"alpelisib, PF.05212384, PI.828, NVP.BEZ235, PKI.179, GDC.0980, TG100.115, YM.201636, voxtalisib, AZD6482, BGT226, TG.100713, PI3K.IN.2, LY303511, LY3023414, PF.04691502, GDC.0941, CUDC.907, GSK2126458, SB.2343, CH5132799",0.377785977033705,0.137272471682025,FALSE
+"H2009","Pearson.est","PLK inhibitor",-0.25585,-0.622,0.9,694,0.939,"NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0457574905606751,0.0273344077338891,FALSE
+"H2009","Pearson.est","potassium channel blocker",0.3143,0.902,0.547,183,0.865,"dofetilide, mepivacaine",0.262012673666569,0.0629838925351858,FALSE
+"H2009","Pearson.est","PPAR receptor agonist",-0.42145,-1.02,0.434,1265,0.71,"pterostilbene",0.362510270487489,0.148741651280925,FALSE
+"H2009","Pearson.est","progesterone receptor agonist",-0.37147,-0.9,0.586,1340,0.771,"melengestrol.acetate, danazol",0.232102383981909,0.112945621949043,FALSE
+"H2009","Pearson.est","proteasome inhibitor",0.29527,0.856,0.602,156,0.846,"MG.132, carfilzomib",0.220403508742175,0.0726296369609765,FALSE
+"H2009","Pearson.est","protein synthesis inhibitor",0.24995,0.712,0.844,288,0.994,"clofoctol, cycloheximide, homoharringtonine, chloramphenicol.palmitate, bruceantin, methacycline, anguidine, emetine",0.073657553374345,0.00261361560268669,FALSE
+"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.38497,-0.926,0.561,914,0.794,"tyrphostin.A9, NVP.TAE226, mubritinib, BMS.599626",0.251037138743839,0.100179497572904,FALSE
+"H2009","Pearson.est","RAF inhibitor",-0.30464,-0.738,0.782,1345,0.85,"sorafenib, TAK.632",0.106793246940152,0.0705810742857073,FALSE
+"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.38129,-0.915,0.594,1126,0.778,"cabozantinib, sunitinib, sorafenib",0.226213555018806,0.109020403010311,FALSE
+"H2009","Pearson.est","retinoid receptor agonist",-0.61883,-1.49,0.0612,1285,0.557,"adapalene, fenretinide, bexarotene",1.21324857785444,0.254144804826271,FALSE
+"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.38373,-0.939,0.538,1008,0.809,"clofarabine, fludarabine, cladribine, pentostatin",0.269217724333611,0.0920514783877277,FALSE
+"H2009","Pearson.est","serotonin receptor agonist",-0.56269,-1.35,0.135,920,0.668,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",0.869666231504994,0.175223537524454,FALSE
+"H2009","Pearson.est","serotonin receptor antagonist",-0.52625,-1.28,0.19,1391,0.554,"lurasidone, aripiprazole",0.721246399047171,0.25649023527157,FALSE
+"H2009","Pearson.est","sodium channel blocker",-0.47074,-1.15,0.296,1243,0.692,"quinidine, triamterene, ajmaline, lappaconite",0.528708288941061,0.159893905543242,FALSE
+"H2009","Pearson.est","src inhibitor",0.36716,1.02,0.388,20,0.88,"dasatinib, saracatinib",0.411168274405793,0.0555173278498314,FALSE
+"H2009","Pearson.est","sterol demethylase inhibitor",-0.51326,-1.25,0.208,1000,0.542,"terconazole, ketoconazole",0.681936665037238,0.266000713461613,FALSE
+"H2009","Pearson.est","TGF beta receptor inhibitor",-0.33625,-0.811,0.706,1356,0.845,"adaprev",0.151195298948196,0.0731432910503077,FALSE
+"H2009","Pearson.est","thymidylate synthase inhibitor",0.33864,0.938,0.465,258,0.92,"capecitabine, doxifluridine, ftorafur",0.332547047110046,0.0362121726544447,FALSE
+"H2009","Pearson.est","topoisomerase inhibitor",-0.37367,-0.906,0.589,891,0.777,"valrubicin, voreloxin, camptothecin, topotecan, nemorubicin, etoposide.phosphate, SN.38, TAS.103, fleroxacin, rubitecan, dexrazoxane, genz.644282, irinotecan",0.229884705212898,0.109578981199086,FALSE
+"H2009","Pearson.est","tubulin polymerization inhibitor",0.19821,0.576,0.952,278,0.947,"mebendazole, CYT.997, BNC105, paclitaxel, vincristine, vindesine, epothilone.b",0.0213630516155257,0.0236500209967266,FALSE
+"H2009","Pearson.est","tyrosine kinase inhibitor",-0.31367,-0.769,0.768,1090,0.855,"NVP.TAE226, mubritinib, cabozantinib, sunitinib, GTP.14564, BMS.599626, sorafenib, UNC2250",0.114638779968488,0.0680338852718274,FALSE
+"H2009","Pearson.est","VEGFR inhibitor",-0.35663,-0.868,0.622,1085,0.791,"RAF265, axitinib, PD.173074, linifanib, cabozantinib, sunitinib, lenvatinib, MK.2461, ENMD.2076, tivozanib, sorafenib, MGCD.265, lucitanib, KI.8751",0.206209615309181,0.101823516502323,FALSE
+"H2009","Pearson.est","vitamin D receptor agonist",-0.59065,-1.45,0.0788,1286,0.541,"maxacalcitol, paricalcitol, tacalcitol",1.10347378251044,0.266802734893431,FALSE
+"HCC4006","Pearson.est","EGFR inhibitor",0.31362,0.918,0.557,77,0.854,"pelitinib, vandetanib, canertinib, brigatinib, erlotinib, rociletinib, BMS.690514, XL.647, afatinib",0.254144804826271,0.068542129310995,FALSE
+"HCC4006","Pearson.est","Abl kinase inhibitor",-0.54753,-1.32,0.145,1074,0.577,"metatinib, flumatinib, nilotinib, KW.2449, imatinib, ponatinib, tozasertib",0.838631997765025,0.238824186844269,FALSE
+"HCC4006","Pearson.est","acetylcholine receptor agonist",-0.40891,-0.981,0.495,959,0.846,"xanomeline, nicotine, nefiracetam, pilocarpine",0.305394801066431,0.0726296369609765,FALSE
+"HCC4006","Pearson.est","acetylcholine receptor antagonist",-0.4195,-1.01,0.444,670,0.832,"darifenacin, diphemanil, dicycloverine, methscopolamine, iododexetimide",0.35261702988538,0.0798766737092761,FALSE
+"HCC4006","Pearson.est","adenosine receptor antagonist",-0.62184,-1.52,0.0497,1229,0.462,"MRS.1220, CGS.15943, SCH.58261",1.30364361126667,0.335358024443874,FALSE
+"HCC4006","Pearson.est","adrenergic receptor agonist",-0.37382,-0.921,0.56,1036,0.882,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.2518119729938,0.0545314148681803,FALSE
+"HCC4006","Pearson.est","adrenergic receptor antagonist",0.39999,1.22,0.224,252,0.649,"prazosin, vincamine, RS.17053, imiloxan, atenolol...., practolol, levobunolol, dihydroergocristine, idazoxan",0.649751981665837,0.187755303199631,FALSE
+"HCC4006","Pearson.est","AKT inhibitor",-0.5334,-1.29,0.173,1053,0.556,"GDC.0068, triciribine, ONC201, uprosertib, CCT128930, A.674563",0.761953896871205,0.254925208417942,FALSE
+"HCC4006","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27703,-0.681,0.868,890,0.918,"CEP.37440, NVP.TAE684, AZD3463, AP26113, alectinib, DMH1",0.0614802748235081,0.0371573187987575,FALSE
+"HCC4006","Pearson.est","androgen receptor antagonist",-0.55423,-1.33,0.147,909,0.587,"nilutamide, flutamide, bicalutamide",0.832682665251824,0.231361898752386,FALSE
+"HCC4006","Pearson.est","antioxidant",-0.46971,-1.14,0.292,1296,0.653,"benfotiamine, trolox",0.534617148551582,0.185086818724926,FALSE
+"HCC4006","Pearson.est","AP inhibitor",0.57911,1.67,0.0258,32,0.474,"GDC.0152, birinapant",1.58838029403677,0.324221658325915,FALSE
+"HCC4006","Pearson.est","ATPase inhibitor",0.30218,0.872,0.586,138,0.891,"k.strophanthidin, digitoxin, ouabain",0.232102383981909,0.0501222959631252,FALSE
+"HCC4006","Pearson.est","Aurora kinase inhibitor",-0.64017,-1.54,0.0477,1200,0.72,"CCT129202, KW.2449, barasertib.HQPA, AMG900, ENMD.2076, SNS.314, aurora.a.inhibitor.i, PF.03814735, MK.8745, AT.9283, barasertib, hesperadin, tozasertib",1.32148162095989,0.142667503568732,FALSE
+"HCC4006","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53029,-1.28,0.181,886,0.55,"valnemulin, azalomycin.b, josamycin, tilmicosin, radezolid, dirithromycin",0.742321425130815,0.259637310505756,FALSE
+"HCC4006","Pearson.est","bacterial DNA gyrase inhibitor",0.53241,1.56,0.0957,235,0.48,"sarafloxacin, finafloxacin, novobiocin, sparfloxacin",1.01908806222316,0.318758762624413,FALSE
+"HCC4006","Pearson.est","BCL inhibitor",-0.54705,-1.33,0.145,1166,0.587,"gossypol, ABT.737",0.838631997765025,0.231361898752386,FALSE
+"HCC4006","Pearson.est","Bcr.Abl kinase inhibitor",-0.53114,-1.3,0.159,1074,0.56,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.798602875679548,0.2518119729938,FALSE
+"HCC4006","Pearson.est","benzodiazepine receptor agonist",0.21624,0.611,0.933,46,0.969,"ZK.93423, gamma.aminobutyric.acid",0.0301183562535,0.0136762229492347,FALSE
+"HCC4006","Pearson.est","bromodomain inhibitor",-0.68154,-1.67,0.0214,1007,1,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",1.66958622665081,0,FALSE
+"HCC4006","Pearson.est","calcium channel blocker",-0.63627,-1.53,0.0526,1251,0.508,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.27901425584626,0.294136287716081,FALSE
+"HCC4006","Pearson.est","CC chemokine receptor antagonist",-0.46332,-1.13,0.319,1002,0.653,"SB.225002, PF.04136309, navarixin",0.496209316942819,0.185086818724926,FALSE
+"HCC4006","Pearson.est","CDK inhibitor",-0.47845,-1.16,0.276,996,0.677,"palbociclib, AZD5438, BMS.265246, NU6027, JNJ.7706621, indisulam, kenpaullone, abemaciclib, ribociclib, indirubin, R547, arcyriaflavin.a",0.559090917934782,0.169411331314856,FALSE
+"HCC4006","Pearson.est","CHK inhibitor",0.51032,1.45,0.0882,209,0.427,"SCH.900776, CHIR.124, LY2603618, LY2606368",1.05453141486818,0.369572124974976,FALSE
+"HCC4006","Pearson.est","cyclooxygenase inhibitor",-0.34444,-0.828,0.706,970,0.791,"curcumin, tepoxalin, metoxibutropate, indoprofen, FK.3311, piroxicam, naproxen, aspirin, pterostilbene, FR.122047, tryptanthrin",0.151195298948196,0.101823516502323,FALSE
+"HCC4006","Pearson.est","cytochrome P450 inhibitor",0.34402,1.01,0.382,289,0.716,"PF.4981517, morin, eplerenone, metyrapone",0.417936637088291,0.145086977692144,FALSE
+"HCC4006","Pearson.est","DNA alkylating agent",-0.36436,-0.877,0.627,918,0.845,"carmustine, carboplatin, temozolomide, ifosfamide, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.202732459169284,0.0731432910503077,FALSE
+"HCC4006","Pearson.est","DNA inhibitor",-0.3881,-0.946,0.54,918,0.877,"carmustine, carboplatin, valrubicin, tirapazamine, pibenzimol, metronidazole, melphalan, primaquine, mechlorethamine",0.267606240177031,0.0570004066339595,FALSE
+"HCC4006","Pearson.est","DNA methyltransferase inhibitor",-0.37963,-0.91,0.577,1030,0.841,"fdcyd, disulfiram, RG108",0.238824186844269,0.0752040042020878,FALSE
+"HCC4006","Pearson.est","DNA polymerase inhibitor",0.25486,0.722,0.793,1081,0.89,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, trifluridine, foscarnet, cidofovir",0.100726812682396,0.0506099933550872,FALSE
+"HCC4006","Pearson.est","DNA synthesis inhibitor",-0.35257,-0.85,0.666,833,0.821,"cisplatin, anisomycin, artesunate, azodicarbonamide, estramustine.phosphate, altretamine, CB.10.277, enocitabine, mitomycin.c",0.176525770829699,0.0856568428805592,FALSE
+"HCC4006","Pearson.est","dopamine receptor antagonist",-0.36829,-0.91,0.587,1100,0.841,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.231361898752386,0.0752040042020878,FALSE
+"HCC4006","Pearson.est","estrogen receptor agonist",0.49076,1.46,0.1,31,0.514,"PPT, levonorgestrel",1,0.289036881004724,FALSE
+"HCC4006","Pearson.est","estrogen receptor antagonist",-0.68093,-1.65,0.0196,1262,0.676,"toremifene, danazol, fulvestrant",1.70774392864352,0.170053304058364,FALSE
+"HCC4006","Pearson.est","FGFR inhibitor",-0.59068,-1.45,0.081,1171,0.439,"PD.173074, MK.2461, erdafitinib, lenvatinib, lucitanib",1.09151498112135,0.357535479757879,FALSE
+"HCC4006","Pearson.est","FLT3 inhibitor",-0.57714,-1.4,0.106,1127,0.522,"sunitinib, tandutinib, KW.2449, GTP.14564, TG.101348, ENMD.2076, sorafenib, ponatinib, quizartinib, tozasertib",0.97469413473523,0.282329496997738,FALSE
+"HCC4006","Pearson.est","glucocorticoid receptor agonist",0.4117,1.2,0.256,290,0.604,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, ciclesonide, prednisolone, halcinonide, triamcinolone.acetonide, fludroxycortide, desonide",0.59176003468815,0.218963061378868,FALSE
+"HCC4006","Pearson.est","glutamate receptor antagonist",0.28657,0.819,0.682,132,0.826,"SIB.1757, latrepirdine, kynurenic.acid",0.166215625343521,0.0830199526796178,FALSE
+"HCC4006","Pearson.est","glycogen synthase kinase inhibitor",-0.49768,-1.22,0.226,1175,0.637,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin, CHIR.98014",0.645891560852599,0.19586056766465,FALSE
+"HCC4006","Pearson.est","growth factor receptor inhibitor",-0.50215,-1.19,0.264,863,0.656,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.578396073130169,0.18309616062434,FALSE
+"HCC4006","Pearson.est","HCV inhibitor",0.26808,0.806,0.694,58,0.8,"daclatasvir",0.158640529545145,0.0969100130080564,FALSE
+"HCC4006","Pearson.est","HDAC inhibitor",-0.54329,-1.31,0.166,1049,0.567,"entinostat, PCI.24781, scriptaid, dacinostat, panobinostat, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.779891911959945,0.246416941107093,FALSE
+"HCC4006","Pearson.est","histamine receptor antagonist",-0.24261,-0.593,0.931,1095,0.946,"lafutidine, BF2.649, tecastemizole, epinastine",0.0310503190186574,0.0241088635982073,FALSE
+"HCC4006","Pearson.est","HMGCR inhibitor",-0.25749,-0.624,0.924,1006,0.939,"fluvastatin, lovastatin",0.0343280287798933,0.0273344077338891,FALSE
+"HCC4006","Pearson.est","HSP inhibitor",0.44405,1.29,0.16,323,0.602,"BIIB021, KW.2478, SNX.5422, SNX.2112, alvespimycin, NVP.AUY922, ganetespib, VER.49009",0.795880017344075,0.220403508742175,FALSE
+"HCC4006","Pearson.est","JAK inhibitor",-0.35878,-0.869,0.641,810,0.823,"WHI.P154, TG.02, CEP.33779, lestaurtinib, LY2784544, pacritinib, AZD1480, TG.101348, AT.9283, TG.101209, tozasertib",0.193141970481183,0.0846001647877302,FALSE
+"HCC4006","Pearson.est","KIT inhibitor",-0.44242,-1.07,0.367,1127,0.741,"sunitinib, tandutinib, imatinib, lenvatinib, sorafenib, KI.8751, masitinib",0.435333935747911,0.130181792020672,FALSE
+"HCC4006","Pearson.est","MDM inhibitor",-0.48485,-1.16,0.296,1123,0.677,"serdemetan, RITA",0.528708288941061,0.169411331314856,FALSE
+"HCC4006","Pearson.est","MEK inhibitor",0.63054,1.88,0.0142,177,0.416,"selumetinib, AS.703026, trametinib, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.84771165561694,0.380906669373257,FALSE
+"HCC4006","Pearson.est","MET inhibitor",-0.61123,-1.46,0.0599,1394,0.568,"NVP.BVU972, AMG458",1.22257317761069,0.245651664288981,FALSE
+"HCC4006","Pearson.est","microtubule inhibitor",-0.20263,-0.481,0.983,773,0.984,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.00744648216786438,0.00700490156865849,FALSE
+"HCC4006","Pearson.est","mTOR inhibitor",-0.47602,-1.14,0.303,817,0.653,"NVP.BEZ235, AZD8055, temsirolimus, deforolimus, voxtalisib, OSI.027, PF.05212384, PKI.179, torin.2, MLN0128, sirolimus, LY303511, XL388, torin.1, LY3023414, PF.04691502, ku.0063794, GSK2126458, WYE.354, AZD2014, SB.2343",0.518557371497695,0.185086818724926,FALSE
+"HCC4006","Pearson.est","NFkB pathway inhibitor",-0.35071,-0.854,0.653,1323,0.831,"EVP4593, betulinic.acid",0.185086818724926,0.080398976215889,FALSE
+"HCC4006","Pearson.est","opioid receptor agonist",-0.36522,-0.873,0.609,738,0.833,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.215382707367125,0.0793549985932124,FALSE
+"HCC4006","Pearson.est","p38 MAPK inhibitor",-0.46799,-1.15,0.29,1340,0.677,"SB.239063, skepinone.l",0.537602002101044,0.169411331314856,FALSE
+"HCC4006","Pearson.est","PARP inhibitor",-0.63686,-1.53,0.0449,1189,0.508,"AG.14361, PJ.34, E7449, niraparib",1.34775365899668,0.294136287716081,FALSE
+"HCC4006","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49434,-1.19,0.242,1103,0.656,"crenolanib, sunitinib, linifanib, axitinib, tandutinib, imatinib, lenvatinib, sorafenib, ponatinib, KI.8751, masitinib",0.616184634019569,0.18309616062434,FALSE
+"HCC4006","Pearson.est","phosphatase inhibitor",-0.43859,-1.07,0.367,840,0.741,"AS.1949490, sodium.stibogluconate, BVT.948, CID.5458317, alexidine, GSK2830371",0.435333935747911,0.130181792020672,FALSE
+"HCC4006","Pearson.est","phosphodiesterase inhibitor",0.29624,0.846,0.633,1022,0.88,"cilostamide, EMD.53998, anagrelide, enoximone, avanafil, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.198596289982645,0.0555173278498314,FALSE
+"HCC4006","Pearson.est","PI3K inhibitor",-0.41176,-0.985,0.483,871,0.861,"voxtalisib, PF.05212384, YM.201636, PKI.179, PI3K.IN.2, AZD6482, TG.100713, BGT226, LY303511, LY3023414, PF.04691502, GDC.0941, GSK2126458, CUDC.907, CH5132799, SB.2343",0.316052869248488,0.0649968485463452,FALSE
+"HCC4006","Pearson.est","PLK inhibitor",-0.34936,-0.836,0.669,787,0.81,"BI.2536, NMS.1286937, volasertib, rigosertib, GW.843682X",0.174573882232177,0.0915149811213502,FALSE
+"HCC4006","Pearson.est","potassium channel blocker",0.27925,0.822,0.665,167,0.872,"dofetilide, mepivacaine",0.177178354696895,0.0594835150674328,FALSE
+"HCC4006","Pearson.est","PPAR receptor agonist",-0.37953,-0.929,0.56,1298,0.888,"pterostilbene",0.2518119729938,0.051587034221399,FALSE
+"HCC4006","Pearson.est","progesterone receptor agonist",-0.34099,-0.835,0.689,1322,0.796,"melengestrol.acetate, danazol",0.161780778092374,0.0990869322623309,FALSE
+"HCC4006","Pearson.est","proteasome inhibitor",0.38436,1.09,0.33,117,0.678,"MG.132, carfilzomib",0.481486060122112,0.168770306132937,FALSE
+"HCC4006","Pearson.est","protein synthesis inhibitor",-0.29786,-0.729,0.804,1268,0.879,"thiostrepton, florfenicol, azomycin..2.nitroimidazole.",0.0947439512515487,0.0560111249262281,FALSE
+"HCC4006","Pearson.est","protein tyrosine kinase inhibitor",-0.37837,-0.918,0.583,1092,0.866,"NVP.TAE226, mubritinib, BMS.599626",0.234331445240986,0.0624821079826534,FALSE
+"HCC4006","Pearson.est","RAF inhibitor",-0.25243,-0.625,0.906,1293,0.954,"sorafenib, TAK.632",0.0428718023231869,0.0204516252959049,FALSE
+"HCC4006","Pearson.est","RET tyrosine kinase inhibitor",-0.37109,-0.879,0.641,1127,0.86,"sunitinib, cabozantinib, sorafenib",0.193141970481183,0.0655015487564323,FALSE
+"HCC4006","Pearson.est","retinoid receptor agonist",-0.55568,-1.34,0.154,1254,0.646,"adapalene, fenretinide, bexarotene",0.812479279163537,0.189767482004916,FALSE
+"HCC4006","Pearson.est","ribonucleotide reductase inhibitor",-0.31069,-0.756,0.776,804,0.861,"fludarabine, clofarabine, cytarabine, cladribine, pentostatin",0.110138278741812,0.0649968485463452,FALSE
+"HCC4006","Pearson.est","serotonin receptor agonist",-0.59799,-1.45,0.0708,1275,0.439,"ipsapirone, aripiprazole",1.14996674231023,0.357535479757879,FALSE
+"HCC4006","Pearson.est","serotonin receptor antagonist",-0.514,-1.22,0.216,1382,0.637,"lurasidone, aripiprazole",0.665546248849069,0.19586056766465,FALSE
+"HCC4006","Pearson.est","sodium channel blocker",-0.42123,-1.03,0.429,906,0.811,"oxcarbazepine, cibenzoline, A.803467, triamterene, quinidine, ajmaline, lappaconite",0.367542707815276,0.090979145788844,FALSE
+"HCC4006","Pearson.est","src inhibitor",0.35834,1.05,0.352,19,0.697,"dasatinib, saracatinib",0.453457336521869,0.156767221901991,FALSE
+"HCC4006","Pearson.est","sterol demethylase inhibitor",-0.65288,-1.61,0.0352,1099,0.598,"terconazole, ketoconazole",1.45345733652187,0.223298816011589,FALSE
+"HCC4006","Pearson.est","TGF beta receptor inhibitor",-0.39388,-0.952,0.542,1385,0.887,"adaprev",0.266000713461613,0.0520763801682736,FALSE
+"HCC4006","Pearson.est","thymidylate synthase inhibitor",0.4026,1.18,0.244,218,0.569,"capecitabine, doxifluridine, ftorafur",0.612610173661271,0.244887733604929,FALSE
+"HCC4006","Pearson.est","topoisomerase inhibitor",-0.35465,-0.845,0.68,900,0.813,"etoposide.phosphate, voreloxin, valrubicin, camptothecin, nemorubicin, rubitecan, fleroxacin, SN.38, dexrazoxane, TAS.103, genz.644282, irinotecan",0.167491087293764,0.0899094544059319,FALSE
+"HCC4006","Pearson.est","tubulin polymerization inhibitor",0.14697,0.433,1,236,0.996,"mebendazole, CYT.997, BNC105, paclitaxel, vindesine",0,0.00174066157630127,FALSE
+"HCC4006","Pearson.est","tyrosine kinase inhibitor",-0.30598,-0.758,0.77,1092,0.874,"NVP.TAE226, sunitinib, mubritinib, cabozantinib, BMS.599626, GTP.14564, sorafenib, UNC2250",0.113509274827518,0.058488567365597,FALSE
+"HCC4006","Pearson.est","VEGFR inhibitor",-0.36819,-0.892,0.618,1127,0.856,"sunitinib, linifanib, axitinib, cabozantinib, PD.173074, MK.2461, ENMD.2076, lenvatinib, sorafenib, MGCD.265, tivozanib, lucitanib, KI.8751",0.209011524911184,0.0675262353228468,FALSE
+"HCC4006","Pearson.est","vitamin D receptor agonist",-0.61241,-1.45,0.0765,1288,0.439,"paricalcitol, maxacalcitol, tacalcitol",1.11633856484638,0.357535479757879,FALSE
+"HCC2279","Pearson.est","EGFR inhibitor",0.42545,1.18,0.247,173,0.525,"pelitinib, canertinib, vandetanib, rociletinib, XL.647, afatinib, brigatinib, erlotinib, BMS.690514, CUDC.101, dacomitinib, neratinib, AZD8931, lapatinib",0.607303046740334,0.279840696594043,FALSE
+"HCC2279","Pearson.est","Abl kinase inhibitor",-0.51902,-1.26,0.2,1034,0.782,"metatinib, KW.2449, imatinib, nilotinib, flumatinib, ponatinib, tozasertib",0.698970004336019,0.106793246940152,FALSE
+"HCC2279","Pearson.est","acetylcholine receptor agonist",-0.47252,-1.13,0.339,1190,0.804,"nicotine, nefiracetam, pilocarpine",0.469800301796918,0.0947439512515487,FALSE
+"HCC2279","Pearson.est","acetylcholine receptor antagonist",-0.50208,-1.2,0.26,724,0.731,"hyoscyamine, darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.585026652029182,0.13608262304214,FALSE
+"HCC2279","Pearson.est","adenosine receptor antagonist",-0.5157,-1.27,0.173,875,0.805,"sulmazole, istradefylline, CGS.15943, MRS.1220, SCH.58261",0.761953896871205,0.0942041196321315,FALSE
+"HCC2279","Pearson.est","adrenergic receptor agonist",-0.46039,-1.1,0.353,1011,0.811,"ritodrine, A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.452225294612177,0.090979145788844,FALSE
+"HCC2279","Pearson.est","adrenergic receptor antagonist",0.45082,1.26,0.181,186,0.545,"prazosin, vincamine, RS.17053, practolol, levobunolol, dihydroergocristine, idazoxan",0.742321425130815,0.263603497723358,FALSE
+"HCC2279","Pearson.est","AKT inhibitor",-0.34255,-0.832,0.675,971,0.864,"uprosertib, ONC201, A.674563, CCT128930",0.170696227168975,0.0634862575211067,FALSE
+"HCC2279","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.3131,-0.754,0.767,1209,0.909,"alectinib, AP26113, DMH1",0.115204636051019,0.0414361167780325,FALSE
+"HCC2279","Pearson.est","androgen receptor antagonist",-0.69017,-1.68,0.0255,1148,0.402,"nilutamide, flutamide, bicalutamide",1.59345981956604,0.39577394691553,FALSE
+"HCC2279","Pearson.est","antioxidant",-0.53854,-1.32,0.16,1357,0.767,"benfotiamine, trolox",0.795880017344075,0.115204636051019,FALSE
+"HCC2279","Pearson.est","AP inhibitor",0.58129,1.65,0.0528,59,0.438,"birinapant, GDC.0152",1.27736607746619,0.3585258894959,FALSE
+"HCC2279","Pearson.est","ATPase inhibitor",0.29322,0.803,0.662,221,0.899,"k.strophanthidin, blebbistatin...., digitoxin",0.1791420105603,0.0462403082667712,FALSE
+"HCC2279","Pearson.est","Aurora kinase inhibitor",-0.49231,-1.21,0.224,1022,0.785,"AMG900, SNS.314, AT.9283, KW.2449, ENMD.2076, aurora.a.inhibitor.i, MK.8745, CCT129202, PF.03814735, barasertib, hesperadin, tozasertib",0.649751981665837,0.105130343254747,FALSE
+"HCC2279","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53932,-1.32,0.156,1082,0.767,"josamycin, tilmicosin, radezolid, dirithromycin",0.806875401645538,0.115204636051019,FALSE
+"HCC2279","Pearson.est","bacterial DNA gyrase inhibitor",0.49883,1.36,0.148,223,0.507,"novobiocin, finafloxacin, sarafloxacin",0.829738284605043,0.294992040666664,FALSE
+"HCC2279","Pearson.est","BCL inhibitor",-0.33794,-0.828,0.658,1360,0.852,"ABT.737",0.181774106386044,0.0695604052332999,FALSE
+"HCC2279","Pearson.est","Bcr.Abl kinase inhibitor",-0.53641,-1.3,0.188,1184,0.769,"imatinib, nilotinib, flumatinib, ponatinib, tozasertib",0.72584215073632,0.114073660198569,FALSE
+"HCC2279","Pearson.est","benzodiazepine receptor agonist",-0.20827,-0.501,0.978,801,0.994,"CL.218872, ivermectin, bentazepam, piperazine, indiplon, temazepam, nefiracetam, lorazepam",0.00966114521239857,0.00261361560268669,FALSE
+"HCC2279","Pearson.est","bromodomain inhibitor",-0.38403,-0.951,0.518,862,0.815,"JQ1...., PFI.1, I.BET151, bromosporine",0.285670240254767,0.0888423912600234,FALSE
+"HCC2279","Pearson.est","calcium channel blocker",-0.44446,-1.08,0.351,1283,0.769,"carboxyamidotriazole, cinnarazine, SR.33805",0.454692883534176,0.114073660198569,FALSE
+"HCC2279","Pearson.est","CC chemokine receptor antagonist",-0.36518,-0.891,0.593,1141,0.803,"PF.04136309, navarixin",0.226945306635737,0.095284454721319,FALSE
+"HCC2279","Pearson.est","CDK inhibitor",-0.23354,-0.562,0.951,1352,1,"R547, indirubin, arcyriaflavin.a",0.0218194830625861,0,FALSE
+"HCC2279","Pearson.est","CHK inhibitor",0.52066,1.43,0.119,97,0.563,"SCH.900776, CHIR.124, LY2603618",0.924453038607469,0.249491605148654,FALSE
+"HCC2279","Pearson.est","cyclooxygenase inhibitor",-0.32507,-0.803,0.697,1026,0.855,"tepoxalin, FK.3311, indoprofen, piroxicam, metoxibutropate, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.156767221901991,0.0680338852718274,FALSE
+"HCC2279","Pearson.est","cytochrome P450 inhibitor",-0.25665,-0.63,0.896,1345,0.982,"clotrimazole",0.0476919903378748,0.00788851221305034,FALSE
+"HCC2279","Pearson.est","DNA alkylating agent",-0.37959,-0.922,0.555,1075,0.826,"cyclophosphamide, carmustine, temozolomide, carboplatin, melphalan, satraplatin, mitomycin.c",0.255707016877324,0.0830199526796178,FALSE
+"HCC2279","Pearson.est","DNA inhibitor",-0.41766,-1.02,0.436,1040,0.793,"pibenzimol, primaquine, carmustine, carboplatin, melphalan, metronidazole, tirapazamine, mechlorethamine",0.360513510731414,0.100726812682396,FALSE
+"HCC2279","Pearson.est","DNA methyltransferase inhibitor",0.43956,1.2,0.262,183,0.538,"decitabine, SGI.1027, azacitidine",0.581698708680255,0.269217724333611,FALSE
+"HCC2279","Pearson.est","DNA polymerase inhibitor",0.31319,0.875,0.568,997,0.81,"cephalomannine, menadione, idoxuridine, adefovir.dipivoxil, famciclovir, trifluridine, cidofovir, foscarnet",0.245651664288981,0.0915149811213502,FALSE
+"HCC2279","Pearson.est","DNA synthesis inhibitor",-0.38809,-0.94,0.529,840,0.813,"cisplatin, azodicarbonamide, artesunate, nelarabine, estramustine.phosphate, enocitabine, altretamine, CB.10.277, mitomycin.c",0.276544327964814,0.0899094544059319,FALSE
+"HCC2279","Pearson.est","dopamine receptor antagonist",-0.41313,-0.99,0.467,784,0.784,"ziprasidone, clebopride, oxiperomide, raclopride, domperidone, amisulpride, paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.330683119433888,0.105683937315562,FALSE
+"HCC2279","Pearson.est","estrogen receptor agonist",0.45787,1.22,0.238,37,0.556,"PPT, levonorgestrel",0.623423042943488,0.254925208417942,FALSE
+"HCC2279","Pearson.est","estrogen receptor antagonist",-0.76464,-1.85,0.00576,1286,0.287,"toremifene, fulvestrant, danazol",2.23957751657679,0.542118103266008,FALSE
+"HCC2279","Pearson.est","FGFR inhibitor",-0.70487,-1.75,0.0146,1119,0.361,"orantinib, PD.173074, lucitanib, lenvatinib, erdafitinib, MK.2461",1.83564714421556,0.442492798094342,FALSE
+"HCC2279","Pearson.est","FLT3 inhibitor",-0.60535,-1.47,0.0813,998,0.904,"sorafenib, sunitinib, KW.2449, ENMD.2076, midostaurin, TG.101348, tandutinib, GTP.14564, quizartinib, ponatinib, tozasertib",1.08990945440593,0.0438315695246367,FALSE
+"HCC2279","Pearson.est","glucocorticoid receptor agonist",0.41621,1.14,0.273,317,0.545,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, prednisolone, fludroxycortide, halcinonide, triamcinolone.acetonide, fluocinolone.acetonide, desonide",0.563837352959244,0.263603497723358,FALSE
+"HCC2279","Pearson.est","glutamate receptor antagonist",-0.28599,-0.674,0.859,1312,0.955,"MTPG, IEM1754",0.0660068361687577,0.0199966284162537,FALSE
+"HCC2279","Pearson.est","glycogen synthase kinase inhibitor",-0.49341,-1.21,0.24,1257,0.785,"GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.619788758288394,0.105130343254747,FALSE
+"HCC2279","Pearson.est","growth factor receptor inhibitor",-0.41168,-1,0.455,741,0.811,"AZD3463, lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.341988603342888,0.090979145788844,FALSE
+"HCC2279","Pearson.est","HCV inhibitor",0.29815,0.795,0.691,98,0.868,"daclatasvir",0.160521952625802,0.0614802748235081,FALSE
+"HCC2279","Pearson.est","HDAC inhibitor",-0.42237,-1.03,0.412,1098,0.823,"panobinostat, trichostatin.a, givinostat, vorinostat, M.344, R306465, resminostat, RG2833, RGFP966",0.385102783966865,0.0846001647877302,FALSE
+"HCC2279","Pearson.est","histamine receptor antagonist",-0.37141,-0.895,0.597,1205,0.815,"BF2.649, lafutidine, tecastemizole, epinastine",0.224025668870631,0.0888423912600234,FALSE
+"HCC2279","Pearson.est","HMGCR inhibitor",-0.59718,-1.44,0.069,1304,0.757,"lovastatin, fluvastatin",1.16115090926274,0.120904120499927,FALSE
+"HCC2279","Pearson.est","HSP inhibitor",0.63349,1.68,0.0764,269,0.591,"BIIB021, KW.2478, alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, ganetespib, VER.49009",1.11690664142431,0.228412519118745,FALSE
+"HCC2279","Pearson.est","JAK inhibitor",-0.29219,-0.715,0.811,904,0.944,"LY2784544, CEP.33779, AT.9283, AZD1480, TG.101348, TG.101209, tozasertib",0.090979145788844,0.025028005701931,FALSE
+"HCC2279","Pearson.est","KIT inhibitor",-0.44123,-1.07,0.378,1182,0.764,"midostaurin, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.422508200162775,0.11690664142431,FALSE
+"HCC2279","Pearson.est","MDM inhibitor",-0.44998,-1.09,0.361,1383,0.804,"RITA",0.442492798094342,0.0947439512515487,FALSE
+"HCC2279","Pearson.est","MEK inhibitor",0.65343,1.86,0.0505,198,0.532,"trametinib, selumetinib, AS.703026, Ro.4987655, cobimetinib, AZD8330, MEK1.2.inhibitor, TAK.733, PD.198306, PD.0325901",1.29670862188134,0.274088367704952,FALSE
+"HCC2279","Pearson.est","MET inhibitor",-0.66907,-1.6,0.0392,1420,0.525,"NVP.BVU972, AMG458",1.40671393297954,0.279840696594043,FALSE
+"HCC2279","Pearson.est","microtubule inhibitor",0.28517,0.788,0.719,348,0.838,"vinflunine, secnidazole, triclabendazole, podophyllotoxin, vinblastine",0.143271109617117,0.0767559813697235,FALSE
+"HCC2279","Pearson.est","mTOR inhibitor",-0.40617,-0.995,0.458,1054,0.797,"GSK2126458, sirolimus, LY303511, torin.1, LY3023414, PF.04691502, AZD2014, ku.0063794, WYE.354, SB.2343",0.339134521996131,0.0985416786038876,FALSE
+"HCC2279","Pearson.est","NFkB pathway inhibitor",-0.19003,-0.467,0.989,748,0.988,"BAY.11.7085, bortezomib, curcumin, parthenolide, bindarit, EVP4593, betulinic.acid",0.0048037084028206,0.00524305541237188,FALSE
+"HCC2279","Pearson.est","opioid receptor agonist",-0.4829,-1.17,0.29,914,0.77,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.537602002101044,0.113509274827518,FALSE
+"HCC2279","Pearson.est","p38 MAPK inhibitor",-0.50718,-1.23,0.234,1162,0.821,"TAK.715, SB.239063, skepinone.l",0.630784142589857,0.0856568428805592,FALSE
+"HCC2279","Pearson.est","PARP inhibitor",-0.56282,-1.4,0.102,1176,0.715,"niraparib, AG.14361, PJ.34, E7449",0.991399828238082,0.145693958198919,FALSE
+"HCC2279","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45892,-1.1,0.363,998,0.811,"sorafenib, crenolanib, sunitinib, axitinib, orantinib, imatinib, linifanib, tandutinib, lenvatinib, ponatinib, KI.8751, masitinib",0.440093374963888,0.090979145788844,FALSE
+"HCC2279","Pearson.est","phosphatase inhibitor",-0.47707,-1.16,0.292,906,0.761,"AS.1949490, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, alexidine, GSK2830371, BVT.948",0.534617148551582,0.118615343229427,FALSE
+"HCC2279","Pearson.est","phosphodiesterase inhibitor",0.21001,0.58,0.951,1146,0.983,"cilostamide, EMD.53998, avanafil, enoximone, anagrelide, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.0218194830625861,0.00744648216786438,FALSE
+"HCC2279","Pearson.est","PI3K inhibitor",-0.37087,-0.904,0.584,730,0.819,"PI3K.IN.2, NVP.BEZ235, YM.201636, PKI.179, voxtalisib, pilaralisib, BGT226, TG.100713, PI.828, TG100.115, GSK2126458, LY303511, CUDC.907, AZD6482, LY3023414, PF.04691502, GDC.0941, CH5132799, SB.2343",0.233587152887601,0.0867160982395816,FALSE
+"HCC2279","Pearson.est","PLK inhibitor",0.35253,0.974,0.441,940,0.758,"HMN.214, NMS.1286937, GSK461364, BI.2536, volasertib, rigosertib, GW.843682X",0.355561410532161,0.120330794367946,FALSE
+"HCC2279","Pearson.est","potassium channel blocker",0.2205,0.601,0.93,319,1,"dofetilide, mepivacaine, oleoylethanolamide",0.0315170514460649,0,FALSE
+"HCC2279","Pearson.est","PPAR receptor agonist",-0.36462,-0.873,0.602,1332,0.814,"pterostilbene",0.220403508742175,0.0893755951107988,FALSE
+"HCC2279","Pearson.est","progesterone receptor agonist",-0.37478,-0.907,0.559,1319,0.834,"melengestrol.acetate, danazol",0.252588192113577,0.0788339493622613,FALSE
+"HCC2279","Pearson.est","proteasome inhibitor",0.51432,1.42,0.118,71,0.485,"MG.132, carfilzomib",0.928117992693875,0.314258261397736,FALSE
+"HCC2279","Pearson.est","protein synthesis inhibitor",0.40401,1.13,0.285,304,0.521,"homoharringtonine, bruceantin, anguidine, cycloheximide, clofoctol, chloramphenicol.palmitate, harringtonine, emetine, methacycline, puromycin",0.54515513999149,0.283162276700476,FALSE
+"HCC2279","Pearson.est","protein tyrosine kinase inhibitor",-0.21701,-0.539,0.968,706,0.995,"PP.121, NVP.TAE226, rheochrysidin, mubritinib, BMS.599626",0.0141246426916063,0.00217691925427455,FALSE
+"HCC2279","Pearson.est","RAF inhibitor",0.33747,0.96,0.46,115,0.739,"AZ.628, LGX818, vemurafenib",0.337242168318426,0.131355561605174,FALSE
+"HCC2279","Pearson.est","RET tyrosine kinase inhibitor",0.32305,0.887,0.574,24,0.833,"vandetanib",0.241088107602027,0.0793549985932124,FALSE
+"HCC2279","Pearson.est","retinoid receptor agonist",-0.44498,-1.08,0.353,1195,0.769,"fenretinide, adapalene, bexarotene",0.452225294612177,0.114073660198569,FALSE
+"HCC2279","Pearson.est","ribonucleotide reductase inhibitor",-0.24254,-0.587,0.931,758,1,"clofarabine, hydroxyurea, fludarabine, cytarabine, cladribine, pentostatin",0.0310503190186574,0,FALSE
+"HCC2279","Pearson.est","serotonin receptor agonist",-0.57977,-1.43,0.101,1316,0.695,"ipsapirone, aripiprazole",0.995678626217357,0.158015195409886,FALSE
+"HCC2279","Pearson.est","serotonin receptor antagonist",-0.50347,-1.2,0.261,1361,0.731,"lurasidone, aripiprazole",0.583359492661719,0.13608262304214,FALSE
+"HCC2279","Pearson.est","sodium channel blocker",-0.42177,-1.02,0.434,997,0.793,"cibenzoline, A.803467, oxcarbazepine, triamterene, ajmaline, quinidine, lappaconite",0.362510270487489,0.100726812682396,FALSE
+"HCC2279","Pearson.est","src inhibitor",-0.342,-0.821,0.673,1443,0.844,"masitinib",0.171984935776023,0.073657553374345,FALSE
+"HCC2279","Pearson.est","sterol demethylase inhibitor",-0.59683,-1.45,0.0763,1222,0.84,"terconazole, ketoconazole",1.11747546204512,0.0757207139381184,FALSE
+"HCC2279","Pearson.est","TGF beta receptor inhibitor",-0.38818,-0.958,0.511,1391,0.823,"adaprev",0.291579099865287,0.0846001647877302,FALSE
+"HCC2279","Pearson.est","thymidylate synthase inhibitor",0.55601,1.55,0.086,306,0.471,"capecitabine, doxifluridine, ftorafur, carmofur",1.06550154875643,0.326979092871104,FALSE
+"HCC2279","Pearson.est","topoisomerase inhibitor",0.19146,0.53,0.965,232,0.971,"amsacrine, idarubicin, amonafide, etoposide, teniposide, epirubicin, mitoxantrone",0.0154726866562074,0.0127807700919951,FALSE
+"HCC2279","Pearson.est","tubulin polymerization inhibitor",0.47588,1.34,0.152,352,0.475,"mebendazole, CYT.997, paclitaxel, vindesine, BNC105, vincristine, taltobulin, fosbretabulin, vinorelbine, epothilone.b, verubulin, fenbendazole, podophyllotoxin, dolastatin.10, vinblastine, oxibendazole",0.818156412055227,0.323306390375133,FALSE
+"HCC2279","Pearson.est","tyrosine kinase inhibitor",0.21038,0.584,0.944,179,1,"vandetanib, dasatinib, AV.412, tivantinib, hypericin",0.025028005701931,0,FALSE
+"HCC2279","Pearson.est","VEGFR inhibitor",-0.28007,-0.68,0.849,1064,0.967,"sunitinib, axitinib, ENMD.2076, cabozantinib, orantinib, PD.173074, linifanib, lucitanib, lenvatinib, MK.2461, MGCD.265, tivozanib, KI.8751",0.0710923097560473,0.0145735259169983,FALSE
+"HCC2279","Pearson.est","vitamin D receptor agonist",-0.57276,-1.38,0.129,1196,0.705,"maxacalcitol, paricalcitol, tacalcitol",0.889410289700751,0.151810883008601,FALSE
+"H520","Pearson.est","EGFR inhibitor",0.35524,1.06,0.366,59,0.6,"vandetanib, pelitinib, canertinib, brigatinib, XL.647, erlotinib, rociletinib, BMS.690514, afatinib",0.436518914605589,0.221848749616356,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",-0.46253,-1.13,0.306,1098,0.71,"ponatinib, KW.2449, flumatinib, nilotinib, imatinib, tozasertib",0.51427857351842,0.148741651280925,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",-0.45822,-1.08,0.385,1008,0.804,"nicotine, xanomeline, nefiracetam, pilocarpine",0.414539270491499,0.0947439512515487,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",-0.42094,-1.02,0.454,607,0.823,"hyoscyamine, darifenacin, dicycloverine, diphemanil, methscopolamine, iododexetimide",0.342944147142896,0.0846001647877302,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",-0.54957,-1.33,0.14,1143,0.558,"CGS.15943, MRS.1220, SCH.58261",0.853871964321762,0.253365801062421,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",-0.3374,-0.815,0.703,1307,0.874,"isoetharine, buphenine, norepinephrine",0.153044674980176,0.058488567365597,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",0.37425,1.12,0.288,243,0.602,"vincamine, prazosin, RS.17053, practolol, levobunolol, atenolol...., idazoxan, imiloxan, dihydroergocristine",0.540607512240769,0.220403508742175,FALSE
+"H520","Pearson.est","AKT inhibitor",-0.50868,-1.24,0.196,862,0.6,"AZD5363, triciribine, GDC.0068, ONC201, uprosertib, CCT128930, A.674563",0.707743928643524,0.221848749616356,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31727,-0.75,0.788,1221,0.899,"AP26113, alectinib, DMH1",0.103473782510445,0.0462403082667712,FALSE
+"H520","Pearson.est","androgen receptor antagonist",-0.60977,-1.47,0.0744,1028,0.542,"nilutamide, bicalutamide, flutamide",1.12842706445412,0.266000713461613,FALSE
+"H520","Pearson.est","antioxidant",-0.47738,-1.16,0.282,1283,0.719,"benfotiamine, trolox",0.549750891680639,0.143271109617117,FALSE
+"H520","Pearson.est","AP inhibitor",0.55104,1.56,0.0864,33,0.455,"GDC.0152, birinapant",1.06348625752111,0.341988603342888,FALSE
+"H520","Pearson.est","ATPase inhibitor",0.28511,0.797,0.683,185,0.928,"k.strophanthidin, digitoxin, ouabain, blebbistatin....",0.165579296318467,0.0324520237811379,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.60073,-1.42,0.077,1026,0.477,"ZM.447439, GSK1070916, CCT137690, KW.2449, CCT129202, aurora.a.inhibitor.i, ENMD.2076, AMG900, PF.03814735, barasertib.HQPA, barasertib, MK.8745, SNS.314, AT.9283, hesperadin, tozasertib",1.11350927482752,0.321481620959886,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.51359,-1.26,0.19,1089,0.608,"tilmicosin, josamycin, dirithromycin, radezolid",0.721246399047171,0.216096420727265,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.47609,1.42,0.109,191,0.45,"novobiocin, finafloxacin, sarafloxacin, sparfloxacin",0.962573502059376,0.346787486224656,FALSE
+"H520","Pearson.est","BCL inhibitor",-0.46744,-1.13,0.314,1076,0.71,"gossypol, ABT.737",0.503070351926785,0.148741651280925,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.42933,-1.02,0.457,1098,0.823,"ponatinib, flumatinib, nilotinib, imatinib, tozasertib",0.34008379993015,0.0846001647877302,FALSE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.229,0.677,0.818,114,0.855,"ZK.93423, gamma.aminobutyric.acid, eprinomectin",0.087246696328677,0.0680338852718274,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.79604,-1.94,0,1175,0.0795,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",Inf,1.09963287134353,TRUE
+"H520","Pearson.est","calcium channel blocker",-0.6769,-1.63,0.0281,1281,0.518,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.55129368009492,0.285670240254767,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",-0.58639,-1.43,0.0886,1109,0.543,"PF.04136309, SB.225002, navarixin",1.05256627811295,0.265200170411153,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.45316,-1.07,0.37,1120,0.801,"abemaciclib, NU6027, indisulam, kenpaullone, JNJ.7706621, ribociclib, indirubin, R547, arcyriaflavin.a",0.431798275933005,0.0963674839157623,FALSE
+"H520","Pearson.est","CHK inhibitor",0.62225,1.78,0.0268,101,0.271,"SCH.900776, CHIR.124, LY2603618, LY2606368",1.57186520597121,0.567030709125594,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",-0.32319,-0.783,0.741,995,0.887,"curcumin, metoxibutropate, FK.3311, tepoxalin, piroxicam, aspirin, pterostilbene, naproxen, FR.122047, tryptanthrin",0.130181792020672,0.0520763801682736,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.40357,1.17,0.245,263,0.574,"PF.4981517, morin, eplerenone, metyrapone, itraconazole",0.610833915635468,0.241088107602027,FALSE
+"H520","Pearson.est","DNA alkylating agent",-0.29826,-0.732,0.816,851,0.905,"ifosfamide, carmustine, temozolomide, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.0883098412461389,0.0433514207947967,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.38714,-0.909,0.585,870,0.971,"carmustine, oxaliplatin, carboplatin, valrubicin, metronidazole, pibenzimol, tirapazamine, melphalan, primaquine, mechlorethamine",0.23284413391782,0.0127807700919951,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.34487,-0.831,0.686,1055,0.901,"fdcyd, RG108, disulfiram",0.163675884293248,0.045275209020937,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",0.27778,0.769,0.732,1048,0.869,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, foscarnet, trifluridine, cidofovir",0.135488918941608,0.0609802235513335,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.29778,-0.719,0.808,623,0.889,"cisplatin, cyclocytidine, nelarabine, artemisinin, floxuridine, artesunate, anisomycin, azodicarbonamide, estramustine.phosphate, altretamine, CB.10.277, enocitabine, mitomycin.c",0.0925886392254138,0.0510982390297863,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",-0.40314,-0.969,0.518,835,0.867,"oxiperomide, clebopride, domperidone, amisulpride, paliperidone, nemonapride, UH.232...., lurasidone, mesoridazine",0.285670240254767,0.0619809025237897,FALSE
+"H520","Pearson.est","estrogen receptor agonist",0.43776,1.24,0.207,56,0.678,"PPT, levonorgestrel",0.684029654543082,0.168770306132937,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",-0.66321,-1.58,0.0457,1250,0.55,"toremifene, fulvestrant, danazol",1.34008379993015,0.259637310505756,FALSE
+"H520","Pearson.est","FGFR inhibitor",-0.63791,-1.53,0.057,1025,0.434,"orantinib, PD.173074, erdafitinib, MK.2461, lenvatinib, lucitanib",1.24412514432751,0.362510270487489,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.59095,-1.42,0.0862,954,0.477,"pacritinib, lestaurtinib, sunitinib, midostaurin, ponatinib, KW.2449, tandutinib, sorafenib, ENMD.2076, TG.101348, GTP.14564, quizartinib, tozasertib",1.06449273417529,0.321481620959886,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",0.26934,0.78,0.73,115,0.902,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone",0.136677139879544,0.0447934624580583,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",0.25807,0.746,0.742,139,0.81,"SIB.1757, latrepirdine, kynurenic.acid",0.129596094720973,0.0915149811213502,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",-0.5495,-1.33,0.151,1179,0.558,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, CHIR.98014, indirubin",0.821023052706831,0.253365801062421,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.52103,-1.26,0.188,819,0.608,"AZD3463, danusertib, GSK1904529A, lestaurtinib, GSK1838705A, GW.441756",0.72584215073632,0.216096420727265,FALSE
+"H520","Pearson.est","HCV inhibitor",0.27385,0.768,0.719,44,0.822,"daclatasvir",0.143271109617117,0.0851281824599496,FALSE
+"H520","Pearson.est","HDAC inhibitor",-0.54114,-1.29,0.163,996,0.627,"dacinostat, ACY.1215, PCI.24781, entinostat, panobinostat, scriptaid, AR.42, trichostatin.a, givinostat, vorinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.787812395596042,0.202732459169284,FALSE
+"H520","Pearson.est","histamine receptor antagonist",-0.25236,-0.612,0.918,1445,0.947,"epinastine",0.0371573187987575,0.0236500209967266,FALSE
+"H520","Pearson.est","HMGCR inhibitor",-0.3457,-0.83,0.692,759,0.884,"atorvastatin, mevastatin, lovastatin, fluvastatin",0.159893905543242,0.0535477349869269,FALSE
+"H520","Pearson.est","HSP inhibitor",0.5048,1.42,0.124,198,0.45,"BIIB021, KW.2478, NVP.AUY922, SNX.5422, SNX.2112, ganetespib, alvespimycin",0.906578314837765,0.346787486224656,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.37616,-0.905,0.594,753,0.954,"AZ960, WHI.P154, atiprimod, TG.02, pacritinib, CEP.33779, lestaurtinib, LY2784544, AZD1480, TG.101348, AT.9283, TG.101209, tozasertib",0.226213555018806,0.0204516252959049,FALSE
+"H520","Pearson.est","KIT inhibitor",-0.44326,-1.06,0.405,1203,0.8,"tandutinib, imatinib, sorafenib, lenvatinib, KI.8751, masitinib",0.392544976785331,0.0969100130080564,FALSE
+"H520","Pearson.est","MDM inhibitor",-0.59462,-1.43,0.0744,1158,0.543,"serdemetan, RITA",1.12842706445412,0.265200170411153,FALSE
+"H520","Pearson.est","MEK inhibitor",0.63993,1.83,0.0179,91,0.428,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733",1.74714696902011,0.368556230986828,FALSE
+"H520","Pearson.est","MET inhibitor",-0.53035,-1.27,0.182,1385,0.647,"NVP.BVU972, AMG458",0.739928612014925,0.1890957193313,FALSE
+"H520","Pearson.est","microtubule inhibitor",-0.32868,-0.777,0.737,900,0.879,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.132532512140949,0.0560111249262281,FALSE
+"H520","Pearson.est","mTOR inhibitor",-0.43418,-1.05,0.399,813,0.799,"deforolimus, WYE.125132, AZD8055, voxtalisib, torin.2, PF.05212384, PKI.179, sirolimus, LY3023414, XL388, LY303511, torin.1, PF.04691502, GSK2126458, ku.0063794, WYE.354, AZD2014, SB.2343",0.399027104313252,0.0974532206860086,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",-0.3597,-0.874,0.605,1351,0.906,"betulinic.acid, EVP4593",0.218244625347531,0.0428718023231869,FALSE
+"H520","Pearson.est","opioid receptor agonist",-0.36211,-0.862,0.626,733,0.906,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.20342566678957,0.0428718023231869,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.52127,-1.25,0.201,1366,0.602,"SB.239063, skepinone.l",0.696803942579511,0.220403508742175,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.71313,-1.68,0.0144,1261,0.537,"AG.14361, E7449, PJ.34, niraparib",1.84163750790475,0.270025714300444,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.49223,-1.18,0.261,1023,0.696,"crenolanib, orantinib, sunitinib, ponatinib, linifanib, axitinib, tandutinib, imatinib, sorafenib, lenvatinib, KI.8751, masitinib",0.583359492661719,0.157390760389438,FALSE
+"H520","Pearson.est","phosphatase inhibitor",-0.40914,-0.991,0.469,685,0.866,"bis.maltolato.oxovanadium.IV., AS.1949490, BVT.948, sodium.stibogluconate, CID.5458317, alexidine, GSK2830371",0.328827157284917,0.0624821079826534,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",0.43602,1.23,0.221,821,0.601,"cilostamide, EMD.53998, enoximone, anagrelide, avanafil, papaverine, zardaverine, YM.976, GSK256066, trequinsin",0.655607726314889,0.22112552799726,FALSE
+"H520","Pearson.est","PI3K inhibitor",-0.41601,-0.99,0.485,781,0.844,"pilaralisib, PI.828, voxtalisib, TG.100713, BGT226, PF.05212384, PKI.179, YM.201636, LY3023414, AZD6482, LY303511, GDC.0941, PF.04691502, GSK2126458, CH5132799, CUDC.907, SB.2343",0.314258261397736,0.073657553374345,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.3747,-0.9,0.607,704,0.941,"BI.2536, volasertib, NMS.1286937, rigosertib, GW.843682X",0.216811308924742,0.0264103765727431,FALSE
+"H520","Pearson.est","potassium channel blocker",0.33742,0.986,0.438,138,0.683,"dofetilide, mepivacaine",0.3585258894959,0.165579296318467,FALSE
+"H520","Pearson.est","PPAR receptor agonist",-0.33752,-0.808,0.719,1255,0.867,"pterostilbene",0.143271109617117,0.0619809025237897,FALSE
+"H520","Pearson.est","progesterone receptor agonist",-0.33263,-0.816,0.709,1308,0.889,"melengestrol.acetate, danazol",0.149353764816933,0.0510982390297863,FALSE
+"H520","Pearson.est","proteasome inhibitor",0.3242,0.949,0.48,129,0.703,"carfilzomib, MG.132",0.318758762624413,0.153044674980176,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.29759,-0.727,0.79,1205,0.896,"thiostrepton, florfenicol, azomycin..2.nitroimidazole.",0.102372908709559,0.0476919903378748,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.36831,-0.887,0.591,910,0.945,"CP.724714, NVP.TAE226, BMS.599626, mubritinib",0.228412519118745,0.0245681914907371,FALSE
+"H520","Pearson.est","RAF inhibitor",-0.25985,-0.619,0.902,1027,0.958,"RAF265, CEP.32496, sorafenib, TAK.632",0.0447934624580583,0.0186344909214556,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.34244,-0.834,0.675,989,0.915,"apatinib, sunitinib, cabozantinib, sorafenib",0.170696227168975,0.0385789059335517,FALSE
+"H520","Pearson.est","retinoid receptor agonist",-0.61623,-1.53,0.0465,1258,0.434,"adapalene, fenretinide, bexarotene",1.33254704711005,0.362510270487489,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.2577,-0.624,0.914,746,0.97,"fludarabine, clofarabine, cytarabine, cladribine, pentostatin",0.0390538042661686,0.0132282657337552,FALSE
+"H520","Pearson.est","serotonin receptor agonist",-0.65109,-1.54,0.0442,1320,0.57,"ipsapirone, aripiprazole",1.35457773065091,0.244125144327509,FALSE
+"H520","Pearson.est","serotonin receptor antagonist",-0.58782,-1.4,0.0976,1389,0.489,"lurasidone, aripiprazole",1.01055018233331,0.31069114087638,FALSE
+"H520","Pearson.est","sodium channel blocker",-0.46987,-1.13,0.312,968,0.71,"cibenzoline, oxcarbazepine, A.803467, ajmaline, triamterene, quinidine, lappaconite",0.505845405981557,0.148741651280925,FALSE
+"H520","Pearson.est","src inhibitor",0.38442,1.09,0.303,18,0.601,"dasatinib, saracatinib",0.518557371497695,0.22112552799726,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",-0.57116,-1.35,0.123,1004,0.581,"terconazole, ketoconazole",0.910094888560602,0.235823867609669,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",-0.36183,-0.875,0.629,1381,0.925,"adaprev",0.201349354554731,0.0338582672609674,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",0.42381,1.19,0.209,207,0.6,"capecitabine, doxifluridine, ftorafur",0.679853713888946,0.221848749616356,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",-0.36852,-0.883,0.612,892,0.931,"fleroxacin, camptothecin, nemorubicin, rubitecan, valrubicin, etoposide.phosphate, voreloxin, SN.38, genz.644282, TAS.103, dexrazoxane, irinotecan",0.213248577854439,0.0310503190186574,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.19093,-0.463,0.99,800,0.988,"parbendazole, albendazole, flubendazole, indibulin, nocodazole, plinabulin, docetaxel, ABT.751, KX2.391, epothilone.d",0.00436480540245009,0.00524305541237188,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",-0.25436,-0.609,0.925,962,0.934,"tyrphostin.AG.99, apatinib, NVP.TAE226, sunitinib, cabozantinib, BMS.599626, sorafenib, mubritinib, GTP.14564, UNC2250",0.0338582672609674,0.0296531237699066,FALSE
+"H520","Pearson.est","VEGFR inhibitor",-0.34613,-0.838,0.671,1025,0.928,"orantinib, RAF265, sunitinib, PD.173074, cabozantinib, linifanib, axitinib, MK.2461, sorafenib, lenvatinib, ENMD.2076, tivozanib, MGCD.265, lucitanib, KI.8751",0.173277479831008,0.0324520237811379,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",-0.4907,-1.19,0.253,979,0.699,"ercalcitriol, maxacalcitol, paricalcitol, tacalcitol",0.596879478824182,0.155522824254319,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",0.47478,1.32,0.182,249,0.451,"pelitinib, canertinib, vandetanib, XL.647, rociletinib, afatinib, erlotinib, BMS.690514, brigatinib, CUDC.101, dacomitinib, AZD8931, neratinib, lapatinib, PD.168393, poziotinib, AEE788, gefitinib, osimertinib",0.739928612014925,0.345823458122039,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",-0.47548,-1.18,0.271,1010,0.743,"metatinib, KW.2449, flumatinib, imatinib, nilotinib, ponatinib, tozasertib",0.567030709125594,0.129011186239425,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",-0.43946,-1.07,0.377,1160,0.688,"nicotine, nefiracetam, pilocarpine",0.423658649794207,0.162411561764489,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.5104,-1.24,0.218,736,0.738,"hyoscyamine, darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.661543506395395,0.131943638176958,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",-0.47068,-1.15,0.313,859,0.691,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.504455662453552,0.160521952625802,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",-0.46174,-1.12,0.351,1106,0.654,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.454692883534176,0.184422251675733,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",0.408,1.12,0.314,224,0.627,"prazosin, vincamine, RS.17053, practolol, dihydroergocristine, levobunolol, idazoxan",0.503070351926785,0.202732459169284,FALSE
+"HCC15","Pearson.est","AKT inhibitor",-0.38643,-0.924,0.54,923,0.848,"triciribine, uprosertib, ONC201, A.674563, CCT128930",0.267606240177031,0.0716041477432862,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31408,-0.765,0.745,1222,0.896,"alectinib, AP26113, DMH1",0.127843727251707,0.0476919903378748,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.67075,-1.69,0.0179,1125,0.562,"nilutamide, flutamide, bicalutamide",1.74714696902011,0.250263684430939,FALSE
+"HCC15","Pearson.est","antioxidant",-0.51722,-1.25,0.222,1343,0.753,"benfotiamine, trolox",0.653647025549361,0.123205023799299,FALSE
+"HCC15","Pearson.est","AP inhibitor",0.5202,1.45,0.103,62,0.529,"birinapant, GDC.0152",0.987162775294828,0.276544327964814,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",0.26415,0.732,0.787,214,0.979,"k.strophanthidin, blebbistatin...., digitoxin",0.104025267640935,0.00921730819686218,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",-0.54382,-1.34,0.15,1025,0.833,"barasertib.HQPA, KW.2449, AMG900, aurora.a.inhibitor.i, CCT129202, SNS.314, ENMD.2076, MK.8745, barasertib, AT.9283, PF.03814735, hesperadin, tozasertib",0.823908740944319,0.0793549985932124,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53761,-1.3,0.159,1108,0.895,"josamycin, tilmicosin, radezolid, dirithromycin",0.798602875679548,0.048176964684088,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.49343,1.4,0.126,194,0.523,"novobiocin, finafloxacin, sarafloxacin",0.899629454882437,0.281498311132726,FALSE
+"HCC15","Pearson.est","BCL inhibitor",-0.38774,-0.943,0.519,1362,0.831,"ABT.737",0.284832642151542,0.080398976215889,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.51875,-1.27,0.203,1188,0.861,"flumatinib, imatinib, nilotinib, ponatinib, tozasertib",0.692503962086787,0.0649968485463452,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.21446,0.576,0.936,91,0.987,"ZK.93423, gamma.aminobutyric.acid",0.0287241512618947,0.00568284733036327,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",-0.44616,-1.11,0.354,910,0.653,"JQ1...., PFI.1, I.BET151, bromosporine",0.450996737974212,0.185086818724926,FALSE
+"HCC15","Pearson.est","calcium channel blocker",-0.48091,-1.17,0.285,1302,0.733,"cinnarazine, carboxyamidotriazole, SR.33805",0.54515513999149,0.134896025358872,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",-0.32237,-0.785,0.747,703,0.886,"MK.0812, UNBS.5162, SB.225002, PF.04136309, navarixin",0.126679398184601,0.0525662781129492,FALSE
+"HCC15","Pearson.est","CDK inhibitor",-0.28626,-0.711,0.836,921,0.914,"AZD5438, BMS.265246, abemaciclib, JNJ.7706621, ribociclib, kenpaullone, NU6027, R547, indirubin, arcyriaflavin.a",0.0777937225609836,0.0390538042661686,FALSE
+"HCC15","Pearson.est","CHK inhibitor",0.54305,1.47,0.0874,92,0.617,"SCH.900776, LY2603618, CHIR.124",1.0584885673656,0.209714835966758,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.32676,-0.819,0.679,1053,0.888,"tepoxalin, FK.3311, indoprofen, aspirin, piroxicam, metoxibutropate, pterostilbene, naproxen, FR.122047, tryptanthrin",0.168130225719498,0.051587034221399,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",-0.23832,-0.571,0.94,1330,0.978,"clotrimazole",0.0268721464003014,0.00966114521239857,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",-0.35014,-0.841,0.657,1026,0.893,"carmustine, temozolomide, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.182434630440219,0.0491485411114536,FALSE
+"HCC15","Pearson.est","DNA inhibitor",-0.39646,-0.972,0.499,1026,0.819,"carmustine, pibenzimol, primaquine, carboplatin, melphalan, metronidazole, tirapazamine, mechlorethamine",0.30189945437661,0.0867160982395816,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.44184,1.24,0.213,177,0.521,"decitabine, SGI.1027, azacitidine",0.671620396561262,0.283162276700476,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.33542,0.893,0.569,965,0.774,"cephalomannine, menadione, idoxuridine, adefovir.dipivoxil, famciclovir, trifluridine, foscarnet, cidofovir",0.244887733604929,0.111259039317107,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",-0.34133,-0.818,0.709,1070,0.871,"estramustine.phosphate, enocitabine, CB.10.277, altretamine, mitomycin.c",0.149353764816933,0.0599818449923368,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",-0.44915,-1.09,0.378,811,0.671,"ziprasidone, domperidone, clebopride, oxiperomide, raclopride, amisulpride, paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.422508200162775,0.173277479831008,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",0.46611,1.32,0.178,43,0.451,"PPT, levonorgestrel",0.749579997691106,0.345823458122039,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",-0.78428,-1.92,0.00425,1314,0.138,"toremifene, fulvestrant, danazol",2.37161106994969,0.860120913598763,TRUE
+"HCC15","Pearson.est","FGFR inhibitor",-0.68967,-1.68,0.025,1112,0.403,"PD.173074, orantinib, MK.2461, lucitanib, lenvatinib, erdafitinib",1.60205999132796,0.39469495385889,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",-0.62344,-1.48,0.0751,1048,0.599,"sorafenib, KW.2449, sunitinib, ENMD.2076, midostaurin, TG.101348, tandutinib, GTP.14564, ponatinib, quizartinib, tozasertib",1.12436006299583,0.222573177610689,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",0.41327,1.14,0.292,297,0.643,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, ciclesonide, fluocinolone.acetonide, prednisolone, fludroxycortide, triamcinolone.acetonide, desonide, halcinonide",0.534617148551582,0.191789027075778,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",-0.26697,-0.646,0.884,1307,0.952,"MTPG, IEM1754",0.0535477349869269,0.0213630516155257,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.50164,-1.23,0.199,1259,0.725,"GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.701146923590293,0.139661993429006,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",-0.48406,-1.16,0.311,889,0.696,"GSK1904529A, lestaurtinib, GSK1838705A, GW.441756",0.507239610973163,0.157390760389438,FALSE
+"HCC15","Pearson.est","HCV inhibitor",0.31572,0.885,0.591,73,0.748,"daclatasvir",0.228412519118745,0.126098402135539,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",-0.42309,-1.01,0.447,1147,0.764,"givinostat, trichostatin.a, vorinostat, M.344, RG2833, resminostat, R306465, RGFP966",0.349692476868064,0.11690664142431,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",-0.34289,-0.833,0.684,1175,0.886,"BF2.649, lafutidine, tecastemizole, epinastine",0.164943898279884,0.0525662781129492,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",-0.59352,-1.46,0.0816,929,0.515,"mevastatin, atorvastatin, lovastatin, fluvastatin",1.08830984124614,0.288192770958809,FALSE
+"HCC15","Pearson.est","HSP inhibitor",0.61353,1.71,0.028,204,0.478,"BIIB021, KW.2478, SNX.5422, NVP.AUY922, SNX.2112, alvespimycin, ganetespib",1.55284196865778,0.320572103387881,FALSE
+"HCC15","Pearson.est","JAK inhibitor",-0.32444,-0.791,0.726,904,0.895,"lestaurtinib, LY2784544, CEP.33779, AZD1480, AT.9283, TG.101348, TG.101209, tozasertib",0.139063379299906,0.048176964684088,FALSE
+"HCC15","Pearson.est","KIT inhibitor",-0.46522,-1.13,0.32,1048,0.68,"sorafenib, sunitinib, midostaurin, imatinib, tandutinib, lenvatinib, KI.8751, masitinib",0.494850021680094,0.167491087293764,FALSE
+"HCC15","Pearson.est","MDM inhibitor",-0.51524,-1.26,0.205,1063,0.777,"serdemetan, RITA",0.688246138944246,0.109578981199086,FALSE
+"HCC15","Pearson.est","MEK inhibitor",0.65741,1.83,0.0276,188,0.562,"trametinib, AS.703026, selumetinib, Ro.4987655, cobimetinib, AZD8330, MEK1.2.inhibitor, TAK.733, PD.0325901, PD.198306",1.55909091793478,0.250263684430939,FALSE
+"HCC15","Pearson.est","MET inhibitor",-0.64383,-1.58,0.0435,1418,0.595,"NVP.BVU972, AMG458",1.36151074304536,0.22548303427145,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.2114,0.599,0.952,1144,1,"secnidazole, vinflunine, triclabendazole, podophyllotoxin, vinblastine, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0213630516155257,0,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",-0.40126,-0.969,0.48,1013,0.802,"XL388, LY303511, GSK2126458, sirolimus, LY3023414, PF.04691502, torin.1, AZD2014, ku.0063794, WYE.354, SB.2343",0.318758762624413,0.0958256317158365,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",-0.22146,-0.531,0.96,1212,0.984,"EVP4593, betulinic.acid",0.0177287669604316,0.00700490156865849,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",-0.48178,-1.16,0.284,873,0.696,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.546681659952962,0.157390760389438,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",-0.49778,-1.2,0.248,1140,0.729,"TAK.715, SB.239063, skepinone.l",0.605548319173784,0.137272471682025,FALSE
+"HCC15","Pearson.est","PARP inhibitor",-0.63255,-1.52,0.0559,1210,0.568,"niraparib, AG.14361, PJ.34, E7449",1.25258819211358,0.245651664288981,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.50328,-1.22,0.219,1048,0.714,"sorafenib, crenolanib, axitinib, sunitinib, orantinib, linifanib, imatinib, tandutinib, ponatinib, lenvatinib, KI.8751, masitinib",0.659555885159882,0.146301788223826,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",-0.46787,-1.13,0.317,869,0.68,"AS.1949490, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, GSK2830371, BVT.948",0.498940737782249,0.167491087293764,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",0.23922,0.654,0.878,1104,1,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, trequinsin, zardaverine, YM.976, GSK256066",0.0565054840938974,0,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",-0.37127,-0.917,0.571,781,0.839,"PI3K.IN.2, pilaralisib, PKI.179, BGT226, voxtalisib, PI.828, TG.100713, TG100.115, LY303511, GSK2126458, CUDC.907, LY3023414, PF.04691502, AZD6482, GDC.0941, CH5132799, SB.2343",0.243363891754152,0.0762380391712997,FALSE
+"HCC15","Pearson.est","PLK inhibitor",0.32894,0.906,0.53,974,0.792,"HMN.214, GSK461364, BI.2536, NMS.1286937, volasertib, rigosertib, GW.843682X",0.275724130399211,0.101274818410506,FALSE
+"HCC15","Pearson.est","potassium channel blocker",0.23739,0.657,0.884,280,1,"dofetilide, mepivacaine, oleoylethanolamide",0.0535477349869269,0,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.3589,-0.875,0.632,1298,0.855,"pterostilbene",0.199282921717615,0.0680338852718274,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.29644,-0.727,0.816,978,0.912,"norethindrone, dienogest, melengestrol.acetate, danazol",0.0883098412461389,0.0400051616715838,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.47929,1.35,0.116,102,0.524,"carfilzomib, MG.132",0.935542010773082,0.280668713016273,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.37253,1.02,0.4,151,0.77,"homoharringtonine, anguidine, bruceantin, cycloheximide, chloramphenicol.palmitate, clofoctol",0.397940008672038,0.113509274827518,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",-0.2349,-0.571,0.943,674,0.978,"NVP.TAE226, PP.121, rheochrysidin, mubritinib, BMS.599626",0.0254883072626717,0.00966114521239857,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.33598,0.944,0.5,103,0.817,"AZ.628, LGX818, vemurafenib",0.301029995663981,0.0877779434675845,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.33888,0.928,0.516,20,0.797,"vandetanib",0.287350298372789,0.0985416786038876,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",-0.43174,-1.05,0.403,1150,0.708,"fenretinide, adapalene, bexarotene",0.39469495385889,0.149966742310231,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.30566,-0.742,0.777,812,0.909,"hydroxyurea, clofarabine, fludarabine, cytarabine, cladribine, pentostatin",0.109578981199086,0.0414361167780325,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",-0.62101,-1.52,0.0516,1326,0.568,"ipsapirone, aripiprazole",1.28735029837279,0.245651664288981,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",-0.52143,-1.29,0.185,1351,0.857,"lurasidone, aripiprazole",0.732828271596986,0.0670191780768018,FALSE
+"HCC15","Pearson.est","sodium channel blocker",-0.46388,-1.12,0.343,1030,0.654,"cibenzoline, A.803467, ajmaline, oxcarbazepine, triamterene, quinidine, lappaconite",0.464705879957229,0.184422251675733,FALSE
+"HCC15","Pearson.est","src inhibitor",-0.35807,-0.885,0.62,1172,0.858,"PP.1, KX2.391, masitinib",0.207608310501746,0.0665127121512946,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",-0.60277,-1.47,0.0695,1213,0.552,"terconazole, ketoconazole",1.15801519540989,0.258060922270801,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",-0.36973,-0.892,0.599,1389,0.866,"adaprev",0.222573177610689,0.0624821079826534,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.54786,1.52,0.0885,219,0.693,"capecitabine, doxifluridine, ftorafur",1.05305672930217,0.159266765388193,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",-0.17282,-0.415,0.997,865,0.996,"camptothecin, voreloxin, nemorubicin, rubitecan, SN.38, etoposide.phosphate, genz.644282, TAS.103, fleroxacin, dexrazoxane, irinotecan",0.00130484168834428,0.00174066157630127,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.34779,0.953,0.457,402,0.856,"mebendazole, paclitaxel, CYT.997, BNC105, vindesine, vincristine, taltobulin, fosbretabulin, vinorelbine, epothilone.b, fenbendazole, oxibendazole, verubulin, podophyllotoxin, dolastatin.10",0.34008379993015,0.0675262353228468,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.20817,0.567,0.956,196,0.953,"vandetanib, dasatinib, hypericin, AV.412, tivantinib",0.0195421077238999,0.0209070993616736,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",-0.28477,-0.693,0.848,1039,0.918,"cabozantinib, sorafenib, axitinib, sunitinib, PD.173074, orantinib, ENMD.2076, linifanib, MK.2461, lucitanib, lenvatinib, tivozanib, MGCD.265, KI.8751",0.0716041477432862,0.0371573187987575,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",-0.50547,-1.26,0.211,919,0.777,"ercalcitriol, maxacalcitol, tacalcitol, paricalcitol",0.675717544702307,0.109578981199086,FALSE
+"H460","Pearson.est","EGFR inhibitor",0.43205,1.29,0.153,190,0.536,"pelitinib, canertinib, vandetanib, erlotinib, BMS.690514, XL.647, rociletinib, brigatinib, afatinib, AZD8931, dacomitinib, poziotinib, PD.168393, lapatinib, neratinib, icotinib, gefitinib",0.815308569182401,0.27083521030723,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.50146,-1.22,0.224,1030,0.634,"metatinib, flumatinib, nilotinib, imatinib, KW.2449, ponatinib, tozasertib",0.649751981665837,0.197910742118267,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.47795,-1.17,0.279,1004,0.605,"xanomeline, nicotine, nefiracetam, pilocarpine",0.554395796726402,0.218244625347531,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",-0.40278,-0.978,0.501,716,0.794,"diphemanil, dicycloverine, iododexetimide, methscopolamine",0.300162274132754,0.100179497572904,FALSE
+"H460","Pearson.est","adenosine receptor antagonist",-0.50493,-1.22,0.209,781,0.634,"sulmazole, istradefylline, CGS.15943, MRS.1220, SCH.58261",0.679853713888946,0.197910742118267,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",-0.40212,-0.976,0.5,1065,0.778,"clenbuterol, A61603, isoxsuprine, isoetharine, buphenine, norepinephrine",0.301029995663981,0.109020403010311,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",0.36417,1.04,0.341,150,0.65,"prazosin, vincamine, RS.17053, practolol, imiloxan, atenolol....",0.467245621007502,0.187086643357144,FALSE
+"H460","Pearson.est","AKT inhibitor",-0.51338,-1.25,0.214,1119,0.645,"triciribine, ONC201, CCT128930, uprosertib, A.674563",0.669586226650809,0.190440285364732,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.2693,-0.663,0.874,1162,0.933,"AP26113, alectinib, DMH1",0.058488567365597,0.0301183562535,FALSE
+"H460","Pearson.est","androgen receptor antagonist",-0.50086,-1.21,0.242,840,0.631,"nilutamide, flutamide, bicalutamide",0.616184634019569,0.199970640755866,FALSE
+"H460","Pearson.est","antioxidant",-0.48458,-1.17,0.278,1302,0.605,"benfotiamine, trolox",0.555955204081924,0.218244625347531,FALSE
+"H460","Pearson.est","AP inhibitor",0.53199,1.54,0.0667,36,0.695,"birinapant, GDC.0152",1.17587416608345,0.158015195409886,FALSE
+"H460","Pearson.est","ATPase inhibitor",0.32177,0.94,0.498,101,0.639,"k.strophanthidin, ouabain, digitoxin",0.302770657240282,0.1944991418416,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.66418,-1.59,0.0362,1143,0.726,"ZM.447439, CCT129202, CCT137690, aurora.a.inhibitor.i, KW.2449, AMG900, ENMD.2076, barasertib.HQPA, PF.03814735, MK.8745, barasertib, SNS.314, AT.9283, hesperadin, tozasertib",1.44129142946683,0.139063379299906,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.59487,-1.43,0.094,978,0.507,"azalomycin.b, tilmicosin, valnemulin, josamycin, radezolid, dirithromycin",1.0268721464003,0.294992040666664,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.47257,1.39,0.142,216,0.777,"sarafloxacin, finafloxacin, novobiocin, sparfloxacin",0.847711655616944,0.109578981199086,FALSE
+"H460","Pearson.est","BCL inhibitor",-0.54623,-1.34,0.133,1221,0.581,"gossypol, ABT.737",0.876148359032914,0.235823867609669,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.4812,-1.17,0.277,1030,0.605,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.557520230935551,0.218244625347531,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.22779,0.666,0.858,126,0.87,"ZK.93423, gamma.aminobutyric.acid, eprinomectin",0.0665127121512946,0.0604807473813815,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.78728,-1.89,0.00254,1168,0.177,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.59516628338006,0.752026733638193,TRUE
+"H460","Pearson.est","calcium channel blocker",-0.65167,-1.57,0.0431,1236,0.617,"cinnarazine, mibefradil, carboxyamidotriazole, SR.33805",1.36552272983927,0.209714835966758,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.57927,-1.39,0.112,1130,0.574,"SB.225002, PF.04136309, navarixin",0.950781977329818,0.241088107602027,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.53921,-1.3,0.166,1054,0.577,"palbociclib, NU6027, AZD5438, BMS.265246, JNJ.7706621, kenpaullone, indisulam, abemaciclib, ribociclib, indirubin, arcyriaflavin.a, R547",0.779891911959945,0.238824186844269,FALSE
+"H460","Pearson.est","CHK inhibitor",0.48955,1.36,0.113,109,0.648,"SCH.900776, CHIR.124, LY2603618",0.94692155651658,0.188424994129407,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.32242,-0.796,0.71,933,0.897,"curcumin, metoxibutropate, indoprofen, FK.3311, tepoxalin, piroxicam, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.148741651280925,0.0472075569559079,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",0.39152,1.11,0.307,256,0.576,"PF.4981517, morin, eplerenone, metyrapone",0.512861624522813,0.239577516576788,FALSE
+"H460","Pearson.est","DNA alkylating agent",-0.35346,-0.86,0.649,776,0.884,"carmustine, temozolomide, cisplatin, carboplatin, streptozotocin, ifosfamide, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.187755303199631,0.0535477349869269,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.34979,-0.848,0.651,1099,0.886,"metronidazole, tirapazamine, pibenzimol, primaquine, melphalan, mechlorethamine",0.186419011431808,0.0525662781129492,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.47326,-1.16,0.28,1151,0.606,"fdcyd, RG108, disulfiram",0.552841968657781,0.217527375833714,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",0.28056,0.78,0.702,1044,0.77,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, cidofovir, foscarnet, trifluridine",0.153662887870195,0.113509274827518,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.37767,-0.929,0.575,798,0.852,"cisplatin, azodicarbonamide, artesunate, cyclocytidine, estramustine.phosphate, CB.10.277, anisomycin, altretamine, enocitabine, mitomycin.c",0.24033215531037,0.0695604052332999,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",-0.37798,-0.908,0.599,1110,0.873,"nemonapride, paliperidone, UH.232...., lurasidone, mesoridazine",0.222573177610689,0.0589857562944303,FALSE
+"H460","Pearson.est","estrogen receptor agonist",0.44663,1.25,0.226,37,0.526,"PPT, levonorgestrel",0.645891560852599,0.279014255846261,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",-0.67382,-1.69,0.0218,1283,0.529,"toremifene, danazol, fulvestrant",1.6615435063954,0.276544327964814,FALSE
+"H460","Pearson.est","FGFR inhibitor",-0.53145,-1.29,0.181,1092,0.571,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",0.742321425130815,0.243363891754152,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.60419,-1.45,0.0875,1048,0.556,"midostaurin, pacritinib, sunitinib, tandutinib, KW.2449, ponatinib, GTP.14564, TG.101348, ENMD.2076, sorafenib, quizartinib, tozasertib",1.05799194697769,0.254925208417942,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",0.45807,1.33,0.144,206,0.569,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, triamcinolone.acetonide, ciclesonide, halcinonide, desonide",0.84163750790475,0.244887733604929,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.30342,0.887,0.594,181,0.687,"SIB.1757, latrepirdine, kynurenic.acid, CGP.37849",0.226213555018806,0.16304326294045,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.5279,-1.3,0.185,1193,0.577,"GSK.3.inhibitor.IX, kenpaullone, LY2090314, indirubin, CHIR.98014",0.732828271596986,0.238824186844269,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.54454,-1.32,0.164,802,0.594,"GSK1904529A, danusertib, AZD3463, lestaurtinib, GSK1838705A, GW.441756",0.785156151952302,0.226213555018806,FALSE
+"H460","Pearson.est","HCV inhibitor",-0.27137,-0.66,0.858,1304,0.906,"narlaprevir",0.0665127121512946,0.0428718023231869,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.55024,-1.35,0.144,1053,0.593,"PCI.24781, panobinostat, entinostat, dacinostat, scriptaid, AR.42, givinostat, trichostatin.a, vorinostat, RG2833, resminostat, R306465, M.344, RGFP966",0.84163750790475,0.226945306635737,FALSE
+"H460","Pearson.est","histamine receptor antagonist",-0.23169,-0.559,0.945,938,0.952,"chloropyramine, cyproheptadine, tecastemizole, lafutidine, BF2.649, epinastine",0.0245681914907371,0.0213630516155257,FALSE
+"H460","Pearson.est","HMGCR inhibitor",-0.28774,-0.709,0.839,1077,0.914,"fluvastatin, lovastatin",0.0762380391712997,0.0390538042661686,FALSE
+"H460","Pearson.est","HSP inhibitor",0.43475,1.23,0.21,278,0.493,"BIIB021, KW.2478, SNX.5422, SNX.2112, alvespimycin, NVP.AUY922, ganetespib",0.677780705266081,0.30715308072277,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.41197,-1.01,0.471,923,0.789,"CEP.33779, lestaurtinib, LY2784544, TG.02, AZD1480, pacritinib, TG.101348, AT.9283, TG.101209, tozasertib",0.326979092871104,0.10292299679058,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.41554,-1.02,0.453,1048,0.811,"midostaurin, sunitinib, tandutinib, lenvatinib, imatinib, sorafenib, KI.8751, masitinib",0.343901797987168,0.090979145788844,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.62445,-1.5,0.0524,1247,0.754,"serdemetan, RITA",1.28066871301627,0.122628654130226,FALSE
+"H460","Pearson.est","MEK inhibitor",0.62567,1.85,0.0205,160,0.42,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, AZD8330, cobimetinib, TAK.733, PD.198306, PD.0325901",1.68824613894425,0.3767507096021,FALSE
+"H460","Pearson.est","MET inhibitor",-0.57053,-1.37,0.109,1357,0.583,"NVP.BVU972, AMG458",0.962573502059376,0.234331445240986,FALSE
+"H460","Pearson.est","microtubule inhibitor",-0.32533,-0.79,0.736,906,0.872,"estramustine.phosphate, colchicine, cabazitaxel, D.64131",0.133122185662501,0.0594835150674328,FALSE
+"H460","Pearson.est","mTOR inhibitor",-0.40812,-0.99,0.476,792,0.81,"deforolimus, WYE.125132, voxtalisib, AZD8055, PKI.179, MLN0128, sirolimus, torin.2, XL388, LY303511, LY3023414, torin.1, PF.04691502, GSK2126458, ku.0063794, WYE.354, AZD2014, SB.2343",0.322393047279507,0.0915149811213502,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",-0.40028,-0.982,0.492,1373,0.806,"EVP4593, betulinic.acid",0.30803489723264,0.0936649581949093,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.33528,-0.811,0.704,1098,0.891,"trimebutine, cebranopadol",0.152427340857888,0.0501222959631252,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",-0.49149,-1.19,0.247,915,0.627,"TAK.715, talmapimod, SB.242235, SB.239063, skepinone.l",0.607303046740334,0.202732459169284,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.61577,-1.49,0.048,1154,0.667,"AG.14361, PJ.34, E7449, niraparib",1.31875876262441,0.175874166083451,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.44807,-1.09,0.365,1066,0.718,"sunitinib, linifanib, crenolanib, tandutinib, axitinib, lenvatinib, imatinib, ponatinib, sorafenib, KI.8751, masitinib",0.437707135543525,0.1438755557577,FALSE
+"H460","Pearson.est","phosphatase inhibitor",-0.43302,-1.06,0.385,745,0.765,"bis.maltolato.oxovanadium.IV., sodium.stibogluconate, AS.1949490, BVT.948, CID.5458317, alexidine, GSK2830371",0.414539270491499,0.116338564846382,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",0.33102,0.979,0.445,972,0.715,"cilostamide, EMD.53998, avanafil, enoximone, anagrelide, papaverine, zardaverine, GSK256066, trequinsin, YM.976",0.351639989019068,0.145693958198919,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.37002,-0.895,0.595,899,0.879,"TG.100713, PKI.179, YM.201636, BGT226, AZD6482, GDC.0941, LY303511, LY3023414, PF.04691502, GSK2126458, CH5132799, CUDC.907, SB.2343",0.22548303427145,0.0560111249262281,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.46492,-1.13,0.298,902,0.653,"NMS.1286937, volasertib, BI.2536, rigosertib, GW.843682X",0.525783735923745,0.185086818724926,FALSE
+"H460","Pearson.est","potassium channel blocker",0.31924,0.94,0.493,145,0.639,"dofetilide, mepivacaine",0.30715308072277,0.1944991418416,FALSE
+"H460","Pearson.est","PPAR receptor agonist",-0.32679,-0.784,0.747,1216,0.864,"pterostilbene",0.126679398184601,0.0634862575211067,FALSE
+"H460","Pearson.est","progesterone receptor agonist",-0.36334,-0.879,0.623,1158,0.888,"dienogest, melengestrol.acetate, danazol",0.20551195334083,0.051587034221399,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.29128,0.818,0.635,129,0.753,"carfilzomib, MG.132",0.197226274708024,0.123205023799299,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.32194,-0.781,0.743,1248,0.853,"thiostrepton, florfenicol, azomycin..2.nitroimidazole.",0.129011186239425,0.069050968832477,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.34806,-0.841,0.694,1078,0.879,"NVP.TAE226, BMS.599626, mubritinib",0.158640529545145,0.0560111249262281,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.28838,-0.692,0.849,1332,0.918,"sorafenib, TAK.632",0.0710923097560473,0.0371573187987575,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.30763,-0.738,0.806,1066,0.895,"sunitinib, cabozantinib, sorafenib",0.0936649581949093,0.048176964684088,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.58861,-1.44,0.0834,1211,0.528,"adapalene, fenretinide, bexarotene",1.07883394936226,0.277366077466188,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.33067,-0.795,0.744,928,0.881,"fludarabine, clofarabine, cladribine, pentostatin",0.128427064454121,0.0550240915879521,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.59417,-1.48,0.0782,1046,0.605,"zolmitriptan, ipsapirone, aripiprazole",1.10679324694015,0.218244625347531,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.51412,-1.24,0.21,1380,0.639,"lurasidone, aripiprazole",0.677780705266081,0.1944991418416,FALSE
+"H460","Pearson.est","sodium channel blocker",-0.41969,-1.01,0.451,996,0.789,"cibenzoline, A.803467, triamterene, quinidine, ajmaline, lappaconite",0.345823458122039,0.10292299679058,FALSE
+"H460","Pearson.est","src inhibitor",0.38878,1.16,0.269,11,0.553,"dasatinib, saracatinib",0.570247719997592,0.257274868695302,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.59928,-1.45,0.0683,1007,0.556,"terconazole, ketoconazole",1.16557929631847,0.254925208417942,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",-0.36061,-0.872,0.631,1359,0.881,"adaprev",0.199970640755866,0.0550240915879521,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",0.33524,0.966,0.495,204,0.685,"capecitabine, doxifluridine, ftorafur",0.305394801066431,0.164309428507574,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.43336,-1.04,0.426,936,0.788,"nemorubicin, topotecan, fleroxacin, valrubicin, etoposide.phosphate, camptothecin, voreloxin, rubitecan, SN.38, dexrazoxane, genz.644282, TAS.103, irinotecan",0.370590400897281,0.103473782510445,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.25649,-0.631,0.904,931,0.917,"indibulin, flubendazole, albendazole, plinabulin, nocodazole, ABT.751, docetaxel, epothilone.d, KX2.391",0.0438315695246367,0.0376306643299789,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.2775,-0.661,0.879,1066,0.92,"sunitinib, NVP.TAE226, BMS.599626, cabozantinib, mubritinib, GTP.14564, sorafenib, UNC2250",0.0560111249262281,0.0362121726544447,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.34231,-0.826,0.697,1066,0.885,"sunitinib, linifanib, PD.173074, RAF265, MK.2461, cabozantinib, axitinib, lenvatinib, ENMD.2076, sorafenib, MGCD.265, tivozanib, lucitanib, KI.8751",0.156767221901991,0.0530567293021746,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",-0.50499,-1.2,0.247,867,0.629,"alfacalcidol, ercalcitriol, maxacalcitol, paricalcitol, tacalcitol",0.607303046740334,0.201349354554731,FALSE
+"A549","Pearson.est","EGFR inhibitor",0.39186,1.09,0.32,256,0.834,"pelitinib, canertinib, vandetanib, brigatinib, erlotinib, XL.647, afatinib, rociletinib, BMS.690514, dacomitinib, neratinib, AZD8931, PD.168393, lapatinib, poziotinib, AEE788, icotinib, CUDC.101",0.494850021680094,0.0788339493622613,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",-0.5224,-1.27,0.18,1055,0.595,"metatinib, KW.2449, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.744727494896694,0.22548303427145,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",-0.41942,-1.03,0.432,1075,0.717,"nicotine, nefiracetam, pilocarpine",0.364516253185088,0.1444808443322,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",-0.46813,-1.12,0.339,741,0.7,"darifenacin, diphemanil, dicycloverine, iododexetimide, methscopolamine",0.469800301796918,0.154901959985743,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",-0.53642,-1.3,0.168,1127,0.582,"CGS.15943, MRS.1220, SCH.58261",0.774690718274137,0.235077015350112,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",-0.42171,-1.02,0.436,1143,0.699,"isoxsuprine, clenbuterol, isoetharine, norepinephrine, buphenine",0.360513510731414,0.155522824254319,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",0.37555,1.06,0.356,272,0.681,"prazosin, vincamine, RS.17053, dihydroergocristine, levobunolol, idazoxan, imiloxan, atenolol...., practolol",0.448550002027125,0.166852888087215,FALSE
+"A549","Pearson.est","AKT inhibitor",-0.48625,-1.19,0.265,991,0.644,"GDC.0068, triciribine, ONC201, uprosertib, A.674563, CCT128930",0.576754126063192,0.191114132640188,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.22256,0.639,0.908,64,0.894,"brigatinib, GW.788388",0.0419141514789149,0.0486624812040823,FALSE
+"A549","Pearson.est","androgen receptor antagonist",-0.56106,-1.35,0.113,1004,0.715,"nilutamide, flutamide, bicalutamide",0.94692155651658,0.145693958198919,FALSE
+"A549","Pearson.est","antioxidant",-0.51247,-1.23,0.231,1329,0.601,"benfotiamine, trolox",0.636388020107856,0.22112552799726,FALSE
+"A549","Pearson.est","AP inhibitor",0.67189,1.98,0.0136,36,0.286,"GDC.0152, birinapant",1.86646109162978,0.543633966870957,FALSE
+"A549","Pearson.est","ATPase inhibitor",0.31492,0.883,0.602,140,1,"k.strophanthidin, digitoxin, ouabain",0.220403508742175,0,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.61234,-1.48,0.0788,1089,0.669,"CCT137690, ENMD.2076, KW.2449, AMG900, barasertib.HQPA, SNS.314, CCT129202, aurora.a.inhibitor.i, AT.9283, PF.03814735, MK.8745, barasertib, hesperadin, tozasertib",1.10347378251044,0.174573882232177,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.50919,-1.24,0.189,752,0.606,"azithromycin, azalomycin.b, valnemulin, josamycin, tilmicosin, radezolid, dirithromycin",0.723538195826756,0.217527375833714,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.48781,1.38,0.143,158,0.511,"finafloxacin, novobiocin, sarafloxacin",0.844663962534938,0.291579099865287,FALSE
+"A549","Pearson.est","BCL inhibitor",-0.42032,-1.02,0.45,1203,0.699,"gossypol, ABT.737",0.346787486224656,0.155522824254319,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.52202,-1.26,0.217,1055,0.588,"metatinib, nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.66354026615147,0.230622673923862,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",-0.21624,-0.523,0.962,898,0.985,"ivermectin, indiplon, piperazine, temazepam, nefiracetam, lorazepam",0.0168249279621871,0.00656376950238827,FALSE
+"A549","Pearson.est","bromodomain inhibitor",-0.61977,-1.49,0.0685,1095,0.761,"PFI.1, JQ1...., bromosporine, I.BET151",1.16430942850757,0.118615343229427,FALSE
+"A549","Pearson.est","calcium channel blocker",-0.57959,-1.4,0.0827,1182,0.686,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.08249449044745,0.163675884293248,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",-0.42716,-1.04,0.418,1208,0.718,"PF.04136309, navarixin",0.378823718224965,0.1438755557577,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.45261,-1.09,0.348,1044,0.697,"AZD5438, BMS.265246, indisulam, JNJ.7706621, kenpaullone, NU6027, abemaciclib, ribociclib, indirubin, R547, arcyriaflavin.a",0.458420756053419,0.156767221901991,FALSE
+"A549","Pearson.est","CHK inhibitor",0.49092,1.43,0.097,106,0.519,"SCH.900776, LY2603618, CHIR.124",1.01322826573376,0.284832642151542,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",-0.31878,-0.777,0.761,916,0.882,"metoxibutropate, curcumin, FK.3311, indoprofen, tepoxalin, piroxicam, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.118615343229427,0.0545314148681803,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",0.29378,0.847,0.612,241,0.956,"PF.4981517, eplerenone, morin",0.213248577854439,0.0195421077238999,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.39862,-0.955,0.519,903,0.768,"cisplatin, ifosfamide, temozolomide, carboplatin, carmustine, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.284832642151542,0.114638779968488,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.38216,-0.92,0.561,1002,0.76,"carboplatin, carmustine, pibenzimol, melphalan, primaquine, metronidazole, tirapazamine, mechlorethamine",0.251037138743839,0.119186407719209,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.30399,0.882,0.573,222,0.943,"decitabine, SGI.1027, azacitidine",0.24184537803261,0.0254883072626717,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",0.25278,0.718,0.77,1084,0.881,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, cidofovir, trifluridine, foscarnet",0.113509274827518,0.0550240915879521,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.31991,-0.783,0.744,698,0.909,"cyclocytidine, nelarabine, altretamine, azodicarbonamide, anisomycin, cisplatin, estramustine.phosphate, artesunate, CB.10.277, enocitabine, mitomycin.c",0.128427064454121,0.0414361167780325,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",-0.40492,-0.98,0.485,1120,0.739,"paliperidone, UH.232...., nemonapride, lurasidone, mesoridazine",0.314258261397736,0.131355561605174,FALSE
+"A549","Pearson.est","estrogen receptor agonist",0.49245,1.43,0.0905,27,0.519,"PPT, levonorgestrel",1.0433514207948,0.284832642151542,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",-0.6821,-1.66,0.0196,1245,0.631,"toremifene, danazol, fulvestrant",1.70774392864352,0.199970640755866,FALSE
+"A549","Pearson.est","FGFR inhibitor",-0.57968,-1.41,0.102,1156,0.84,"PD.173074, MK.2461, lenvatinib, lucitanib, erdafitinib",0.991399828238082,0.0757207139381184,FALSE
+"A549","Pearson.est","FLT3 inhibitor",-0.57059,-1.37,0.114,1069,0.72,"sunitinib, midostaurin, ENMD.2076, KW.2449, tandutinib, GTP.14564, sorafenib, ponatinib, TG.101348, quizartinib, tozasertib",0.943095148663527,0.142667503568732,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",0.46594,1.34,0.158,286,0.495,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, ciclesonide, triamcinolone.acetonide, halcinonide, prednisolone, fludroxycortide, desonide",0.801342913045577,0.305394801066431,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.24802,0.72,0.799,171,0.922,"SIB.1757, latrepirdine, kynurenic.acid",0.0974532206860086,0.0352690789463706,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.47883,-1.16,0.297,1016,0.686,"TWS.119, kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin, CHIR.98014",0.527243550682788,0.163675884293248,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",-0.51526,-1.27,0.224,835,0.595,"lestaurtinib, GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.649751981665837,0.22548303427145,FALSE
+"A549","Pearson.est","HCV inhibitor",0.26876,0.767,0.766,83,0.895,"daclatasvir",0.115771230367396,0.048176964684088,FALSE
+"A549","Pearson.est","HDAC inhibitor",-0.5435,-1.3,0.172,1168,0.582,"scriptaid, panobinostat, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, resminostat, M.344, R306465, RGFP966",0.764471553092451,0.235077015350112,FALSE
+"A549","Pearson.est","histamine receptor antagonist",-0.31569,-0.763,0.776,1021,0.868,"cyproheptadine, nizatidine, BF2.649, tecastemizole, lafutidine, epinastine",0.110138278741812,0.0614802748235081,FALSE
+"A549","Pearson.est","HMGCR inhibitor",-0.37223,-0.903,0.587,1081,0.756,"fluvastatin, lovastatin",0.231361898752386,0.121478204498793,FALSE
+"A549","Pearson.est","HSP inhibitor",0.50358,1.45,0.121,248,0.802,"BIIB021, KW.2478, SNX.5422, SNX.2112, alvespimycin, ganetespib, NVP.AUY922",0.91721462968355,0.0958256317158365,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.37341,-0.903,0.59,1272,0.756,"AT.9283, TG.101348, TG.101209, tozasertib",0.229147988357856,0.121478204498793,FALSE
+"A549","Pearson.est","KIT inhibitor",-0.4559,-1.12,0.336,1069,0.7,"sunitinib, midostaurin, imatinib, tandutinib, lenvatinib, sorafenib, KI.8751, masitinib",0.473660722610156,0.154901959985743,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.57102,-1.4,0.101,1138,0.686,"serdemetan, RITA",0.995678626217357,0.163675884293248,FALSE
+"A549","Pearson.est","MEK inhibitor",0.64319,1.9,0.0211,164,0.207,"selumetinib, trametinib, AS.703026, Ro.4987655, cobimetinib, MEK1.2.inhibitor, TAK.733, AZD8330, PD.198306, PD.0325901",1.67571754470231,0.684029654543082,TRUE
+"A549","Pearson.est","MET inhibitor",-0.66326,-1.62,0.0299,1400,0.552,"NVP.BVU972, AMG458",1.52432881167557,0.258060922270801,FALSE
+"A549","Pearson.est","microtubule inhibitor",-0.16822,-0.409,0.991,1268,0.996,"D.64131",0.00392634551472468,0.00174066157630127,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.4557,-1.11,0.356,725,0.701,"PF.05212384, deforolimus, AZD8055, everolimus, OSI.027, NVP.BEZ235, WYE.125132, voxtalisib, temsirolimus, torin.2, PKI.179, LY303511, MLN0128, XL388, sirolimus, PF.04691502, torin.1, GSK2126458, LY3023414, ku.0063794, AZD2014, WYE.354, SB.2343",0.448550002027125,0.154281982033341,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",-0.38839,-0.929,0.567,1342,0.761,"EVP4593, betulinic.acid",0.246416941107093,0.118615343229427,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.43594,-1.07,0.395,944,0.718,"salvinorin.a, trimebutine, cebranopadol",0.40340290437354,0.1438755557577,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",-0.54469,-1.3,0.143,1039,0.582,"TAK.715, SB.242235, SB.239063, skepinone.l",0.844663962534938,0.235077015350112,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.62814,-1.51,0.055,1223,0.845,"AG.14361, E7449, PJ.34, niraparib",1.25963731050576,0.0731432910503077,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.46497,-1.13,0.315,1144,0.729,"crenolanib, linifanib, imatinib, tandutinib, axitinib, lenvatinib, sorafenib, ponatinib, KI.8751, masitinib",0.501689446210399,0.137272471682025,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.49594,-1.19,0.273,927,0.644,"AS.1949490, sodium.stibogluconate, CID.5458317, BVT.948, alexidine, GSK2830371",0.563837352959244,0.191114132640188,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",0.29833,0.829,0.633,1019,0.933,"cilostamide, EMD.53998, anagrelide, enoximone, avanafil, trequinsin, papaverine, zardaverine, GSK256066, YM.976",0.198596289982645,0.0301183562535,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.42734,-1.04,0.414,828,0.718,"TG100.115, NVP.BEZ235, voxtalisib, YM.201636, TG.100713, PI3K.IN.2, PKI.179, BGT226, LY303511, AZD6482, PF.04691502, GSK2126458, LY3023414, GDC.0941, CUDC.907, CH5132799, SB.2343",0.382999658879101,0.1438755557577,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.24423,-0.586,0.933,872,0.966,"volasertib, rigosertib, GW.843682X",0.0301183562535,0.0150228735845067,FALSE
+"A549","Pearson.est","potassium channel blocker",0.27369,0.791,0.733,160,0.9,"dofetilide, mepivacaine",0.134896025358872,0.0457574905606751,FALSE
+"A549","Pearson.est","PPAR receptor agonist",-0.40929,-0.998,0.474,1314,0.723,"pterostilbene",0.324221658325915,0.140861702705469,FALSE
+"A549","Pearson.est","progesterone receptor agonist",-0.3593,-0.87,0.661,1345,0.793,"melengestrol.acetate, danazol",0.17979854051436,0.100726812682396,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.42683,1.23,0.195,104,0.606,"MG.132, carfilzomib",0.709965388637482,0.217527375833714,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.29716,-0.723,0.808,1415,0.869,"florfenicol, azomycin..2.nitroimidazole.",0.0925886392254138,0.0609802235513335,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.32571,-0.78,0.773,1031,0.895,"NVP.TAE226, BMS.599626, mubritinib",0.111820506081675,0.048176964684088,FALSE
+"A549","Pearson.est","RAF inhibitor",0.29052,0.812,0.72,86,0.91,"vemurafenib, AZ.628, LGX818",0.142667503568732,0.0409586076789064,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.31235,-0.749,0.771,906,0.869,"apatinib, sunitinib, cabozantinib, sorafenib",0.112945621949043,0.0609802235513335,FALSE
+"A549","Pearson.est","retinoid receptor agonist",-0.54094,-1.31,0.153,1292,0.676,"adapalene, fenretinide, bexarotene",0.815308569182401,0.170053304058364,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.31125,-0.763,0.791,783,0.868,"clofarabine, fludarabine, cytarabine, cladribine, pentostatin",0.101823516502323,0.0614802748235081,FALSE
+"A549","Pearson.est","serotonin receptor agonist",-0.54747,-1.32,0.135,1247,0.697,"ipsapirone, aripiprazole",0.869666231504994,0.156767221901991,FALSE
+"A549","Pearson.est","serotonin receptor antagonist",-0.45843,-1.09,0.364,1375,0.697,"lurasidone, aripiprazole",0.438898616350944,0.156767221901991,FALSE
+"A549","Pearson.est","sodium channel blocker",-0.42922,-1.06,0.403,973,0.718,"cibenzoline, oxcarbazepine, A.803467, triamterene, quinidine, ajmaline, lappaconite",0.39469495385889,0.1438755557577,FALSE
+"A549","Pearson.est","src inhibitor",0.36658,1.07,0.352,16,0.724,"dasatinib, saracatinib",0.453457336521869,0.140261433802853,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",-0.7094,-1.74,0.0183,1179,0.653,"terconazole, ketoconazole",1.73754891026957,0.185086818724926,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",-0.37927,-0.937,0.525,1391,0.764,"adaprev",0.279840696594043,0.11690664142431,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",0.39084,1.07,0.331,325,0.724,"capecitabine, doxifluridine, ftorafur, carmofur",0.480172006224281,0.140261433802853,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.39578,-0.948,0.532,920,0.762,"voreloxin, valrubicin, camptothecin, nemorubicin, etoposide.phosphate, SN.38, rubitecan, fleroxacin, TAS.103, genz.644282, dexrazoxane, irinotecan",0.274088367704952,0.1180450286604,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",0.22916,0.689,0.889,365,0.878,"mebendazole, CYT.997, paclitaxel, BNC105, vincristine, vindesine, epothilone.b, verubulin, fosbretabulin, taltobulin, dolastatin.10, vinorelbine, podophyllotoxin",0.0510982390297863,0.0565054840938974,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",-0.24234,-0.589,0.955,1031,0.981,"NVP.TAE226, sunitinib, cabozantinib, BMS.599626, mubritinib, GTP.14564, sorafenib, UNC2250",0.0199966284162537,0.0083309926200515,FALSE
+"A549","Pearson.est","VEGFR inhibitor",-0.30074,-0.737,0.775,1069,0.868,"sunitinib, cabozantinib, ENMD.2076, PD.173074, linifanib, MK.2461, axitinib, lenvatinib, lucitanib, sorafenib, MGCD.265, tivozanib, KI.8751",0.11069829749369,0.0614802748235081,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",-0.55644,-1.34,0.148,1257,0.688,"maxacalcitol, paricalcitol, tacalcitol",0.829738284605043,0.162411561764489,FALSE
+"HCC44","Pearson.est","EGFR inhibitor",0.46107,1.28,0.168,181,0.676,"pelitinib, canertinib, vandetanib, XL.647, BMS.690514, afatinib, brigatinib, erlotinib, rociletinib, dacomitinib, AZD8931, neratinib, lapatinib, poziotinib, CUDC.101, PD.168393, AEE788",0.774690718274137,0.170053304058364,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",-0.5691,-1.4,0.102,1185,0.613,"KW.2449, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.991399828238082,0.212539525481585,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",-0.40697,-0.989,0.484,1055,0.825,"nicotine, nefiracetam, pilocarpine",0.315154638355588,0.0835460514500749,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.4726,-1.16,0.304,986,0.685,"dicycloverine, iododexetimide, methscopolamine",0.517126416391246,0.164309428507574,FALSE
+"HCC44","Pearson.est","adenosine receptor antagonist",-0.56326,-1.35,0.133,873,0.523,"sulmazole, CGS.15943, istradefylline, MRS.1220, SCH.58261",0.876148359032914,0.281498311132726,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.47732,-1.15,0.297,1117,0.683,"A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.527243550682788,0.165579296318467,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",0.38565,1.1,0.31,266,0.661,"prazosin, vincamine, RS.17053, practolol, dihydroergocristine, atenolol...., levobunolol, imiloxan, idazoxan",0.508638306165727,0.17979854051436,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.44724,-1.09,0.354,998,0.698,"triciribine, uprosertib, ONC201, A.674563, CCT128930",0.450996737974212,0.156144577376839,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33558,-0.806,0.713,1234,0.858,"alectinib, AP26113, DMH1",0.146910470148134,0.0665127121512946,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",-0.59204,-1.45,0.0876,1015,0.672,"nilutamide, flutamide, bicalutamide",1.05749589383192,0.172630726946175,FALSE
+"HCC44","Pearson.est","antioxidant",-0.52167,-1.25,0.193,1350,0.647,"benfotiamine, trolox",0.714442690992226,0.1890957193313,FALSE
+"HCC44","Pearson.est","AP inhibitor",0.51529,1.44,0.115,50,0.586,"birinapant, GDC.0152",0.939302159646388,0.232102383981909,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",0.25835,0.764,0.737,2,0.906,"k.strophanthidin",0.132532512140949,0.0428718023231869,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.6182,-1.5,0.0533,1160,0.707,"aurora.a.inhibitor.i, CCT129202, AMG900, KW.2449, barasertib.HQPA, ENMD.2076, SNS.314, AT.9283, barasertib, MK.8745, PF.03814735, hesperadin, tozasertib",1.27327279097343,0.150580586203101,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.49996,-1.22,0.235,1080,0.628,"tilmicosin, josamycin, radezolid, dirithromycin",0.628932137728264,0.202040356262804,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",0.4762,1.39,0.0972,126,0.558,"novobiocin, finafloxacin, sarafloxacin",1.01233373507373,0.253365801062421,FALSE
+"HCC44","Pearson.est","BCL inhibitor",-0.40969,-0.976,0.497,1059,0.829,"gossypol, ABT.737",0.303643611266668,0.0814454694497265,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.56179,-1.39,0.0964,1211,0.587,"flumatinib, nilotinib, imatinib, ponatinib, tozasertib",1.01592296609717,0.231361898752386,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",0.21665,0.608,0.92,53,0.967,"ZK.93423, gamma.aminobutyric.acid",0.0362121726544447,0.0145735259169983,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",-0.56718,-1.38,0.112,1056,0.565,"JQ1...., PFI.1, I.BET151, bromosporine",0.950781977329818,0.247951552180562,FALSE
+"HCC44","Pearson.est","calcium channel blocker",-0.55503,-1.37,0.117,1171,0.547,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",0.931814138253838,0.262012673666569,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.42657,-1.04,0.434,760,0.739,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.362510270487489,0.131355561605174,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.38451,-0.927,0.564,1067,0.86,"BMS.265246, JNJ.7706621, NU6027, abemaciclib, ribociclib, kenpaullone, indirubin, R547, arcyriaflavin.a",0.248720896016658,0.0655015487564323,FALSE
+"HCC44","Pearson.est","CHK inhibitor",0.53261,1.57,0.0574,102,0.712,"SCH.900776, LY2603618, CHIR.124",1.24108810760203,0.147520006363144,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.33995,-0.824,0.689,1021,0.903,"tepoxalin, metoxibutropate, indoprofen, piroxicam, FK.3311, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.161780778092374,0.0443122496864942,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",0.23167,0.669,0.825,254,0.997,"PF.4981517, morin, eplerenone",0.0835460514500749,0.00130484168834428,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",-0.38584,-0.932,0.549,946,0.872,"carmustine, streptozotocin, temozolomide, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.260427655549908,0.0594835150674328,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.38984,-0.952,0.495,1079,0.855,"pibenzimol, carboplatin, metronidazole, melphalan, primaquine, tirapazamine, mechlorethamine",0.305394801066431,0.0680338852718274,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",0.32476,0.952,0.502,202,0.864,"decitabine, SGI.1027, azacitidine",0.299296282854981,0.0634862575211067,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",0.31806,0.925,0.489,990,0.865,"cephalomannine, menadione, famciclovir, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.31069114087638,0.0629838925351858,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",-0.33522,-0.809,0.705,709,0.889,"cyclocytidine, anisomycin, nelarabine, cisplatin, azodicarbonamide, artesunate, estramustine.phosphate, enocitabine, CB.10.277, altretamine, mitomycin.c",0.151810883008601,0.0510982390297863,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.36871,-0.894,0.589,645,0.883,"ziprasidone, clebopride, acetophenazine, piperacetazine, oxiperomide, domperidone, raclopride, amisulpride, paliperidone, nemonapride, UH.232...., lurasidone, mesoridazine",0.229884705212898,0.0540392964224314,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",0.44247,1.27,0.183,28,0.6,"levonorgestrel, PPT",0.737548910269571,0.221848749616356,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",-0.72554,-1.77,0.00759,1284,0.487,"toremifene, fulvestrant, danazol",2.11975822410452,0.312471038785366,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",-0.57576,-1.41,0.102,972,0.646,"orantinib, PD.173074, lenvatinib, MK.2461, erdafitinib, lucitanib",0.991399828238082,0.189767482004916,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.58477,-1.41,0.0854,1126,0.646,"midostaurin, sorafenib, KW.2449, ENMD.2076, tandutinib, TG.101348, GTP.14564, ponatinib, quizartinib, tozasertib",1.06854212931099,0.189767482004916,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",0.39227,1.13,0.272,292,0.663,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, triamcinolone.acetonide, ciclesonide, desonide, fluocinolone.acetonide, prednisolone, halcinonide, fludroxycortide",0.565431095965801,0.178486471595227,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",-0.25259,-0.607,0.916,1291,0.935,"MTPG, IEM1754",0.0381045263321496,0.0291883891274822,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.51643,-1.24,0.215,1152,0.641,"kenpaullone, GSK.3.inhibitor.IX, LY2090314, indirubin, CHIR.98014",0.667561540084395,0.193141970481183,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.51003,-1.23,0.219,817,0.633,"AZD3463, lestaurtinib, GSK1904529A, GSK1838705A, GW.441756",0.659555885159882,0.198596289982645,FALSE
+"HCC44","Pearson.est","HCV inhibitor",0.28531,0.814,0.662,60,0.866,"daclatasvir",0.1791420105603,0.0624821079826534,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",-0.48732,-1.19,0.253,960,0.643,"entinostat, scriptaid, PCI.24781, dacinostat, panobinostat, AR.42, givinostat, trichostatin.a, vorinostat, resminostat, RG2833, R306465, M.344, RGFP966",0.596879478824182,0.191789027075778,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",-0.3457,-0.846,0.649,1193,0.907,"BF2.649, lafutidine, tecastemizole, epinastine",0.187755303199631,0.0423927129399047,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",-0.51603,-1.25,0.213,1245,0.647,"lovastatin, fluvastatin",0.671620396561262,0.1890957193313,FALSE
+"HCC44","Pearson.est","HSP inhibitor",0.55166,1.55,0.0376,283,0.513,"BIIB021, KW.2478, alvespimycin, SNX.5422, NVP.AUY922, SNX.2112, ganetespib, VER.49009",1.42481215507234,0.289882634888184,FALSE
+"HCC44","Pearson.est","JAK inhibitor",-0.34455,-0.844,0.68,889,0.89,"WHI.P154, lestaurtinib, LY2784544, CEP.33779, AZD1480, TG.101348, AT.9283, TG.101209, tozasertib",0.167491087293764,0.0506099933550872,FALSE
+"HCC44","Pearson.est","KIT inhibitor",-0.4698,-1.13,0.317,1126,0.704,"midostaurin, sorafenib, tandutinib, imatinib, lenvatinib, KI.8751, masitinib",0.498940737782249,0.152427340857888,FALSE
+"HCC44","Pearson.est","MDM inhibitor",-0.55641,-1.35,0.137,1119,0.523,"serdemetan, RITA",0.863279432843593,0.281498311132726,FALSE
+"HCC44","Pearson.est","MEK inhibitor",0.65847,1.91,0.0128,173,0.372,"trametinib, selumetinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, AZD8330, cobimetinib, TAK.733, PD.0325901, PD.198306",1.89279003035213,0.429457060118102,FALSE
+"HCC44","Pearson.est","MET inhibitor",-0.66107,-1.6,0.0318,1407,0.933,"NVP.BVU972, AMG458",1.49757288001557,0.0301183562535,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",-0.27795,-0.672,0.894,831,0.925,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0486624812040823,0.0338582672609674,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",-0.37076,-0.895,0.607,708,0.903,"OSI.027, AZD8055, NVP.BEZ235, deforolimus, voxtalisib, torin.2, PKI.179, MLN0128, sirolimus, XL388, GSK2126458, LY303511, PF.04691502, torin.1, LY3023414, ku.0063794, AZD2014, WYE.354, SB.2343",0.216811308924742,0.0443122496864942,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",-0.28038,-0.677,0.856,1255,0.937,"EVP4593, betulinic.acid",0.0675262353228468,0.0282604091122217,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.49043,-1.19,0.246,840,0.643,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.609064892896621,0.191789027075778,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",-0.45882,-1.11,0.342,968,0.7,"SB.242235, TAK.715, SB.239063, skepinone.l",0.465973893943865,0.154901959985743,FALSE
+"HCC44","Pearson.est","PARP inhibitor",-0.63667,-1.54,0.0413,1207,0.693,"AG.14361, niraparib, PJ.34, E7449",1.3840499483436,0.159266765388193,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45476,-1.1,0.368,1088,0.698,"linifanib, crenolanib, axitinib, sorafenib, tandutinib, imatinib, lenvatinib, ponatinib, KI.8751, masitinib",0.434152181326482,0.156144577376839,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",-0.54518,-1.29,0.158,914,0.648,"AS.1949490, sodium.stibogluconate, bis.maltolato.oxovanadium.IV., CID.5458317, alexidine, BVT.948, GSK2830371",0.801342913045577,0.188424994129407,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",0.28442,0.827,0.676,1039,0.894,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.170053304058364,0.0486624812040823,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",-0.35464,-0.863,0.632,724,0.898,"TG100.115, NVP.BEZ235, pilaralisib, voxtalisib, YM.201636, PKI.179, BGT226, TG.100713, GSK2126458, LY303511, AZD6482, PF.04691502, GDC.0941, LY3023414, CH5132799, CUDC.907, SB.2343",0.199282921717615,0.0467236633326956,FALSE
+"HCC44","Pearson.est","PLK inhibitor",-0.28469,-0.691,0.825,632,0.939,"GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.0835460514500749,0.0273344077338891,FALSE
+"HCC44","Pearson.est","potassium channel blocker",0.21721,0.621,0.918,196,1,"dofetilide, mepivacaine",0.0371573187987575,0,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",-0.32995,-0.806,0.722,1246,0.858,"pterostilbene",0.141462802430361,0.0665127121512946,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",-0.33542,-0.818,0.702,1131,0.893,"dienogest, melengestrol.acetate, danazol",0.153662887870195,0.0491485411114536,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",0.4499,1.26,0.166,87,0.543,"carfilzomib, MG.132",0.779891911959945,0.265200170411153,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",0.31401,0.859,0.627,153,0.883,"homoharringtonine, clofoctol, cycloheximide, bruceantin, chloramphenicol.palmitate, anguidine",0.202732459169284,0.0540392964224314,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.27246,-0.665,0.871,593,0.916,"CP.724714, tyrphostin.A9, PP.121, rheochrysidin, NVP.TAE226, mubritinib, BMS.599626",0.0599818449923368,0.0381045263321496,FALSE
+"HCC44","Pearson.est","RAF inhibitor",-0.24677,-0.609,0.924,1001,0.949,"CEP.32496, RAF265, sorafenib, TAK.632",0.0343280287798933,0.0227337875727074,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.30878,0.863,0.609,19,0.933,"vandetanib",0.215382707367125,0.0301183562535,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",-0.43435,-1.06,0.409,1180,0.719,"fenretinide, adapalene, bexarotene",0.388276691992658,0.143271109617117,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.32116,-0.783,0.718,843,0.858,"cytarabine, fludarabine, clofarabine, cladribine, pentostatin",0.1438755557577,0.0665127121512946,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.59191,-1.46,0.0702,1293,0.744,"ipsapirone, aripiprazole",1.15366288787019,0.128427064454121,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.52382,-1.28,0.173,1349,0.637,"lurasidone, aripiprazole",0.761953896871205,0.19586056766465,FALSE
+"HCC44","Pearson.est","sodium channel blocker",-0.43813,-1.06,0.388,991,0.719,"cibenzoline, oxcarbazepine, A.803467, triamterene, ajmaline, quinidine, lappaconite",0.411168274405793,0.143271109617117,FALSE
+"HCC44","Pearson.est","src inhibitor",0.35406,0.966,0.469,17,0.9,"saracatinib, dasatinib",0.328827157284917,0.0457574905606751,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",-0.64766,-1.56,0.0425,1216,0.811,"terconazole, ketoconazole",1.37161106994969,0.090979145788844,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.35969,-0.883,0.619,1379,0.883,"adaprev",0.208309350979882,0.0540392964224314,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",0.43364,1.23,0.229,210,0.532,"capecitabine, doxifluridine, ftorafur",0.640164517660112,0.274088367704952,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",-0.33399,-0.796,0.719,886,0.856,"valrubicin, nemorubicin, etoposide.phosphate, camptothecin, voreloxin, rubitecan, SN.38, fleroxacin, dexrazoxane, genz.644282, TAS.103, irinotecan",0.143271109617117,0.0675262353228468,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",0.17442,0.514,0.991,218,0.979,"mebendazole, paclitaxel, BNC105, vindesine, CYT.997",0.00392634551472468,0.00921730819686218,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.18608,-0.45,0.994,834,0.991,"AMG.208, apatinib, NVP.TAE226, tyrphostin.AG.99, sunitinib, mubritinib, cabozantinib, BMS.599626, sorafenib, GTP.14564, UNC2250",0.00261361560268669,0.00392634551472468,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",-0.28876,-0.695,0.842,972,0.952,"orantinib, sunitinib, RAF265, PD.173074, cabozantinib, linifanib, axitinib, sorafenib, ENMD.2076, lenvatinib, MK.2461, lucitanib, tivozanib, MGCD.265, KI.8751",0.0746879085003505,0.0213630516155257,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",-0.45837,-1.11,0.355,793,0.7,"alfacalcidol, ercalcitriol, maxacalcitol, paricalcitol, tacalcitol",0.449771646944906,0.154901959985743,FALSE
+"H1703","Pearson.est","EGFR inhibitor",0.39102,1.12,0.301,220,0.625,"pelitinib, canertinib, vandetanib, XL.647, brigatinib, afatinib, erlotinib, BMS.690514, rociletinib, dacomitinib, AZD8931, neratinib, PD.168393, CUDC.101, poziotinib, lapatinib",0.521433504406157,0.204119982655925,FALSE
+"H1703","Pearson.est","Abl kinase inhibitor",-0.5569,-1.33,0.142,1093,0.554,"metatinib, flumatinib, nilotinib, KW.2449, imatinib, ponatinib, tozasertib",0.847711655616944,0.25649023527157,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",-0.40463,-0.976,0.499,1095,0.8,"nicotine, nefiracetam, pilocarpine",0.30189945437661,0.0969100130080564,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.47397,-1.15,0.33,985,0.687,"dicycloverine, iododexetimide, methscopolamine",0.481486060122112,0.16304326294045,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",-0.54651,-1.3,0.159,1005,0.56,"istradefylline, CGS.15943, MRS.1220, SCH.58261",0.798602875679548,0.2518119729938,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",-0.38734,-0.933,0.531,835,0.822,"metaraminol, ritodrine, midodrine, A61603, clenbuterol, isoxsuprine, isoetharine, buphenine, norepinephrine",0.274905478918531,0.0851281824599496,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",0.45186,1.31,0.17,227,0.474,"prazosin, vincamine, RS.17053, practolol, imiloxan, dihydroergocristine, levobunolol, atenolol...., idazoxan",0.769551078621726,0.324221658325915,FALSE
+"H1703","Pearson.est","AKT inhibitor",-0.46532,-1.13,0.323,1195,0.681,"ONC201, uprosertib, A.674563, CCT128930",0.490797477668897,0.166852888087215,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25949,-0.623,0.894,906,0.923,"NVP.TAE684, CEP.37440, AZD3463, AP26113, alectinib, DMH1",0.0486624812040823,0.0347982989740879,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",-0.55134,-1.33,0.15,853,0.554,"nilutamide, flutamide, bicalutamide",0.823908740944319,0.25649023527157,FALSE
+"H1703","Pearson.est","antioxidant",-0.49249,-1.21,0.24,1332,0.627,"benfotiamine, trolox",0.619788758288394,0.202732459169284,FALSE
+"H1703","Pearson.est","AP inhibitor",0.60439,1.7,0.0574,38,0.49,"birinapant, GDC.0152",1.24108810760203,0.309803919971486,FALSE
+"H1703","Pearson.est","ATPase inhibitor",0.29462,0.815,0.646,147,0.85,"k.strophanthidin, digitoxin, ouabain",0.189767482004916,0.0705810742857073,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.62369,-1.51,0.0622,1137,0.707,"barasertib.HQPA, KW.2449, CCT129202, ENMD.2076, AMG900, SNS.314, aurora.a.inhibitor.i, PF.03814735, MK.8745, AT.9283, barasertib, hesperadin, tozasertib",1.20620961530918,0.150580586203101,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54825,-1.35,0.132,836,0.674,"azithromycin, azalomycin.b, valnemulin, tilmicosin, josamycin, radezolid, dirithromycin",0.87942606879415,0.17134010346468,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.54456,1.58,0.0368,133,0.506,"finafloxacin, sarafloxacin, novobiocin",1.43415218132648,0.295849483160201,FALSE
+"H1703","Pearson.est","BCL inhibitor",-0.52318,-1.28,0.164,1131,0.522,"gossypol, ABT.737",0.785156151952302,0.282329496997738,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",-0.53866,-1.29,0.177,1093,0.527,"metatinib, flumatinib, nilotinib, imatinib, ponatinib, tozasertib",0.752026733638193,0.278189384787453,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.24645,0.72,0.826,49,0.917,"ZK.93423, gamma.aminobutyric.acid",0.0830199526796178,0.0376306643299789,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",-0.62594,-1.53,0.0587,1121,1,"PFI.1, JQ1...., bromosporine, I.BET151",1.23136189875239,0,FALSE
+"H1703","Pearson.est","calcium channel blocker",-0.6211,-1.51,0.0626,1257,0.707,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.20342566678957,0.150580586203101,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.41835,-1.01,0.463,712,0.82,"RS.504393, MK.0812, SB.225002, PF.04136309, navarixin",0.334419008982047,0.0861861476162833,FALSE
+"H1703","Pearson.est","CDK inhibitor",-0.40481,-0.988,0.499,916,0.798,"palbociclib, AZD5438, indisulam, BMS.265246, JNJ.7706621, ribociclib, abemaciclib, kenpaullone, NU6027, indirubin, R547, arcyriaflavin.a",0.30189945437661,0.0979971086492706,FALSE
+"H1703","Pearson.est","CHK inhibitor",0.49102,1.37,0.13,107,0.517,"SCH.900776, CHIR.124, LY2603618",0.886056647693163,0.286509456906058,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",-0.30235,-0.72,0.821,943,0.87,"metoxibutropate, curcumin, tepoxalin, piroxicam, indoprofen, FK.3311, aspirin, naproxen, pterostilbene, FR.122047, tryptanthrin",0.0856568428805592,0.0604807473813815,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",0.32296,0.935,0.49,323,0.884,"PF.4981517, morin, eplerenone, metyrapone",0.309803919971486,0.0535477349869269,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.377,-0.907,0.581,800,0.85,"streptozotocin, cisplatin, temozolomide, ifosfamide, carmustine, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.235823867609669,0.0705810742857073,FALSE
+"H1703","Pearson.est","DNA inhibitor",-0.40224,-0.96,0.503,1009,0.811,"carmustine, carboplatin, tirapazamine, pibenzimol, metronidazole, primaquine, melphalan, mechlorethamine",0.298432014944073,0.090979145788844,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",-0.32096,-0.778,0.737,1247,0.875,"disulfiram, RG108",0.132532512140949,0.0579919469776868,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",0.30556,0.879,0.597,1008,0.829,"cephalomannine, famciclovir, menadione, adefovir.dipivoxil, idoxuridine, trifluridine, cidofovir, foscarnet",0.224025668870631,0.0814454694497265,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.32107,-0.778,0.734,920,0.875,"artesunate, azodicarbonamide, estramustine.phosphate, altretamine, CB.10.277, enocitabine, mitomycin.c",0.134303940083929,0.0579919469776868,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",-0.33677,-0.807,0.709,1041,0.886,"UH.232...., paliperidone, nemonapride, lurasidone, mesoridazine",0.149353764816933,0.0525662781129492,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",0.5161,1.44,0.1,26,0.616,"levonorgestrel, PPT",1,0.210419287835575,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",-0.69799,-1.67,0.0218,1265,1,"toremifene, danazol, fulvestrant",1.6615435063954,0,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.59329,-1.45,0.0751,1011,0.546,"orantinib, PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",1.12436006299583,0.262807357295263,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",-0.57423,-1.39,0.133,1115,0.606,"sunitinib, tandutinib, KW.2449, ENMD.2076, GTP.14564, TG.101348, sorafenib, ponatinib, quizartinib, tozasertib",0.876148359032914,0.217527375833714,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",0.46603,1.29,0.201,286,0.452,"hydrocortisone, betamethasone, methylprednisolone, fluorometholone, fluocinolone.acetonide, ciclesonide, triamcinolone.acetonide, prednisolone, halcinonide, fludroxycortide, desonide",0.696803942579511,0.344861565188618,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.26803,0.755,0.758,154,0.906,"SIB.1757, latrepirdine, kynurenic.acid",0.120330794367946,0.0428718023231869,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",-0.54867,-1.31,0.161,1218,0.568,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin, CHIR.98014",0.79317412396815,0.245651664288981,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",-0.52426,-1.27,0.195,819,0.52,"GSK1904529A, lestaurtinib, AZD3463, GSK1838705A, GW.441756",0.709965388637482,0.283996656365201,FALSE
+"H1703","Pearson.est","HCV inhibitor",0.33574,0.933,0.494,63,0.825,"daclatasvir",0.306273051076353,0.0835460514500749,FALSE
+"H1703","Pearson.est","HDAC inhibitor",-0.54463,-1.33,0.152,1043,0.554,"PCI.24781, scriptaid, entinostat, dacinostat, panobinostat, AR.42, trichostatin.a, vorinostat, givinostat, RG2833, R306465, resminostat, M.344, RGFP966",0.818156412055227,0.25649023527157,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",-0.31412,-0.766,0.748,1139,0.874,"lafutidine, BF2.649, tecastemizole, epinastine",0.126098402135539,0.058488567365597,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.40881,-0.992,0.488,1151,0.812,"fluvastatin, lovastatin",0.311580177997289,0.0904439707588247,FALSE
+"H1703","Pearson.est","HSP inhibitor",0.50524,1.37,0.146,180,0.517,"BIIB021, KW.2478, SNX.5422, SNX.2112, alvespimycin",0.835647144215563,0.286509456906058,FALSE
+"H1703","Pearson.est","JAK inhibitor",-0.33512,-0.825,0.687,1246,0.915,"TG.101348, AT.9283, TG.101209, tozasertib",0.16304326294045,0.0385789059335517,FALSE
+"H1703","Pearson.est","KIT inhibitor",-0.43721,-1.06,0.4,1115,0.785,"sunitinib, tandutinib, imatinib, lenvatinib, sorafenib, KI.8751, masitinib",0.397940008672038,0.105130343254747,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.53279,-1.29,0.178,1134,0.527,"serdemetan, RITA",0.749579997691106,0.278189384787453,FALSE
+"H1703","Pearson.est","MEK inhibitor",0.63658,1.79,0.0195,174,0.682,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.70996538863748,0.166215625343521,FALSE
+"H1703","Pearson.est","MET inhibitor",-0.63129,-1.5,0.0581,1402,0.624,"NVP.BVU972, AMG458",1.23582386760967,0.204815410317576,FALSE
+"H1703","Pearson.est","microtubule inhibitor",0.1509,0.438,0.996,1231,0.996,"secnidazole, triclabendazole, vinflunine, vinblastine, podophyllotoxin, cytochalasin.b, cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.00174066157630127,0.00174066157630127,FALSE
+"H1703","Pearson.est","mTOR inhibitor",-0.42557,-1.03,0.424,773,0.827,"PF.05212384, NVP.BEZ235, deforolimus, temsirolimus, voxtalisib, OSI.027, PKI.179, torin.2, MLN0128, LY303511, sirolimus, XL388, LY3023414, torin.1, GSK2126458, PF.04691502, ku.0063794, WYE.354, AZD2014, SB.2343",0.372634143407267,0.0824944904474534,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.33785,-0.812,0.697,1309,0.916,"EVP4593, betulinic.acid",0.156767221901991,0.0381045263321496,FALSE
+"H1703","Pearson.est","opioid receptor agonist",-0.41862,-1,0.457,809,0.818,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.34008379993015,0.087246696328677,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",-0.46367,-1.11,0.343,1322,0.7,"SB.239063, skepinone.l",0.464705879957229,0.154901959985743,FALSE
+"H1703","Pearson.est","PARP inhibitor",-0.60621,-1.46,0.0803,1169,0.583,"AG.14361, PJ.34, niraparib, E7449",1.09528445472132,0.234331445240986,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.47221,-1.14,0.305,1067,0.684,"crenolanib, sunitinib, linifanib, tandutinib, axitinib, imatinib, lenvatinib, sorafenib, ponatinib, KI.8751, masitinib",0.515700160653214,0.164943898279884,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.49677,-1.2,0.237,850,0.599,"sodium.stibogluconate, bis.maltolato.oxovanadium.IV., AS.1949490, CID.5458317, BVT.948, alexidine, GSK2830371",0.625251653989896,0.222573177610689,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",0.24131,0.668,0.897,1101,0.945,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, trequinsin, zardaverine, GSK256066, YM.976",0.0472075569559079,0.0245681914907371,FALSE
+"H1703","Pearson.est","PI3K inhibitor",-0.42619,-1.02,0.426,736,0.823,"PI.828, TG100.115, PF.05212384, pilaralisib, NVP.BEZ235, YM.201636, voxtalisib, TG.100713, PI3K.IN.2, PKI.179, BGT226, AZD6482, LY303511, GDC.0941, LY3023414, GSK2126458, PF.04691502, CUDC.907, CH5132799, SB.2343",0.370590400897281,0.0846001647877302,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.27315,-0.651,0.892,676,0.931,"GSK461364, BI.2536, NMS.1286937, volasertib, rigosertib, GW.843682X",0.0496351456238769,0.0310503190186574,FALSE
+"H1703","Pearson.est","potassium channel blocker",0.32007,0.922,0.498,238,0.792,"dofetilide, oleoylethanolamide, mepivacaine",0.302770657240282,0.101274818410506,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",-0.37307,-0.9,0.584,1310,0.843,"pterostilbene",0.233587152887601,0.0741724253752577,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.31491,-0.753,0.784,1301,0.859,"melengestrol.acetate, danazol",0.105683937315562,0.0660068361687577,FALSE
+"H1703","Pearson.est","proteasome inhibitor",0.3938,1.12,0.326,109,0.625,"MG.132, carfilzomib",0.486782399932061,0.204119982655925,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",0.29014,0.836,0.595,175,0.861,"cycloheximide, clofoctol, homoharringtonine, chloramphenicol.palmitate, bruceantin, anguidine",0.22548303427145,0.0649968485463452,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.3074,-0.728,0.781,987,0.876,"NVP.TAE226, mubritinib, BMS.599626",0.1073489661227,0.0574958938319193,FALSE
+"H1703","Pearson.est","RAF inhibitor",-0.26152,-0.634,0.899,1278,0.93,"sorafenib, TAK.632",0.0462403082667712,0.0315170514460649,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",-0.35206,-0.852,0.639,1110,0.889,"cabozantinib, sunitinib, sorafenib",0.1944991418416,0.0510982390297863,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",-0.5551,-1.34,0.138,1287,0.65,"adapalene, fenretinide, bexarotene",0.860120913598763,0.187086643357144,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.33057,-0.794,0.728,776,0.886,"hydroxyurea, clofarabine, cytarabine, fludarabine, cladribine, pentostatin",0.137868620686963,0.0525662781129492,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",-0.57415,-1.42,0.0905,1271,0.575,"ipsapirone, aripiprazole",1.0433514207948,0.24033215531037,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",-0.49512,-1.2,0.263,1369,0.599,"lurasidone, aripiprazole",0.580044251510242,0.222573177610689,FALSE
+"H1703","Pearson.est","sodium channel blocker",-0.38709,-0.947,0.519,1004,0.815,"cibenzoline, A.803467, quinidine, ajmaline, triamterene, lappaconite",0.284832642151542,0.0888423912600234,FALSE
+"H1703","Pearson.est","src inhibitor",0.37515,1.03,0.391,17,0.746,"dasatinib, saracatinib",0.407823242604133,0.127261172527331,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.66846,-1.62,0.0147,1156,0.864,"terconazole, ketoconazole",1.83268266525182,0.0634862575211067,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",-0.36029,-0.875,0.605,1386,0.868,"adaprev",0.218244625347531,0.0614802748235081,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",0.46395,1.31,0.181,208,0.474,"capecitabine, doxifluridine, ftorafur",0.742321425130815,0.324221658325915,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.31615,-0.765,0.744,891,0.859,"voreloxin, valrubicin, etoposide.phosphate, camptothecin, nemorubicin, rubitecan, SN.38, fleroxacin, TAS.103, genz.644282, dexrazoxane, irinotecan",0.128427064454121,0.0660068361687577,FALSE
+"H1703","Pearson.est","tubulin polymerization inhibitor",0.22723,0.665,0.91,355,0.906,"mebendazole, CYT.997, BNC105, paclitaxel, vincristine, vindesine, taltobulin, verubulin, epothilone.b, vinorelbine, oxibendazole",0.0409586076789064,0.0428718023231869,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",-0.24615,-0.59,0.931,1110,0.932,"cabozantinib, sunitinib, mubritinib, BMS.599626, GTP.14564, sorafenib, UNC2250",0.0310503190186574,0.0305840876460186,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",-0.33446,-0.81,0.713,1110,0.9,"cabozantinib, sunitinib, linifanib, PD.173074, axitinib, ENMD.2076, MK.2461, lenvatinib, sorafenib, MGCD.265, lucitanib, tivozanib, KI.8751",0.146910470148134,0.0457574905606751,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",-0.59758,-1.46,0.0734,1254,0.583,"maxacalcitol, paricalcitol, tacalcitol",1.13430394008393,0.234331445240986,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.40182,1.18,0.237,183,0.555,"pelitinib, canertinib, vandetanib, BMS.690514, erlotinib, brigatinib, XL.647, afatinib, rociletinib, AZD8931, PD.168393, dacomitinib, poziotinib, lapatinib, neratinib, icotinib",0.625251653989896,0.255707016877324,FALSE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.51717,-1.27,0.179,1164,0.545,"nilotinib, flumatinib, KW.2449, imatinib, ponatinib, tozasertib",0.747146969020107,0.263603497723358,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.43348,-1.05,0.41,960,0.778,"xanomeline, nicotine, nefiracetam, pilocarpine",0.387216143280265,0.109020403010311,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",-0.49852,-1.22,0.222,852,0.588,"dicycloverine, diphemanil, iododexetimide, methscopolamine",0.653647025549361,0.230622673923862,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",-0.53912,-1.3,0.153,958,0.528,"istradefylline, CGS.15943, MRS.1220, SCH.58261",0.815308569182401,0.277366077466188,FALSE
+"H1299","Pearson.est","adrenergic receptor agonist",-0.36595,-0.873,0.644,996,0.915,"A61603, isoxsuprine, clenbuterol, isoetharine, buphenine, norepinephrine",0.191114132640188,0.0385789059335517,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",0.3726,1.08,0.345,186,0.606,"prazosin, vincamine, RS.17053, practolol, imiloxan, levobunolol, atenolol....",0.462180904926726,0.217527375833714,FALSE
+"H1299","Pearson.est","AKT inhibitor",-0.50255,-1.21,0.228,1101,0.59,"triciribine, ONC201, CCT128930, uprosertib, A.674563",0.642065152999546,0.229147988357856,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24882,-0.607,0.93,888,0.935,"CEP.37440, NVP.TAE684, AZD3463, AP26113, alectinib, DMH1",0.0315170514460649,0.0291883891274822,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",-0.56584,-1.37,0.121,899,0.506,"nilutamide, flutamide, bicalutamide",0.91721462968355,0.295849483160201,FALSE
+"H1299","Pearson.est","antioxidant",-0.48629,-1.19,0.257,1310,0.592,"benfotiamine, trolox",0.590066876668705,0.22767829327708,FALSE
+"H1299","Pearson.est","AP inhibitor",0.59545,1.75,0.0233,27,0.288,"birinapant, GDC.0152",1.63264407897398,0.540607512240769,FALSE
+"H1299","Pearson.est","ATPase inhibitor",0.33368,0.976,0.482,114,0.548,"k.strophanthidin, ouabain, digitoxin",0.31695296176115,0.261219441515631,FALSE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.65789,-1.59,0.033,1158,1,"CCT129202, CCT137690, aurora.a.inhibitor.i, KW.2449, barasertib.HQPA, PF.03814735, AMG900, ENMD.2076, MK.8745, AT.9283, SNS.314, barasertib, hesperadin, tozasertib",1.48148606012211,0,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.58512,-1.42,0.0837,948,0.531,"valnemulin, azalomycin.b, tilmicosin, josamycin, radezolid, dirithromycin",1.07727454200674,0.274905478918531,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.51149,1.49,0.0711,212,0.386,"sarafloxacin, finafloxacin, novobiocin, sparfloxacin",1.14813039927023,0.413412695328245,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.52948,-1.31,0.159,1206,0.561,"gossypol, ABT.737",0.798602875679548,0.251037138743839,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.48467,-1.19,0.257,1164,0.592,"nilotinib, flumatinib, imatinib, ponatinib, tozasertib",0.590066876668705,0.22767829327708,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.23773,0.68,0.885,118,0.853,"gamma.aminobutyric.acid, ZK.93423, eprinomectin",0.0530567293021746,0.069050968832477,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",-0.76933,-1.87,0.00386,1128,0.207,"OTX015, PFI.1, JQ1...., bromosporine, I.BET151",2.41341269532824,0.684029654543082,TRUE
+"H1299","Pearson.est","calcium channel blocker",-0.63135,-1.52,0.052,1237,0.485,"mibefradil, cinnarazine, carboxyamidotriazole, SR.33805",1.2839966563652,0.314258261397736,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.52527,-1.26,0.209,1098,0.521,"SB.225002, PF.04136309, navarixin",0.679853713888946,0.283162276700476,FALSE
+"H1299","Pearson.est","CDK inhibitor",-0.53221,-1.28,0.159,1077,0.549,"palbociclib, BMS.265246, AZD5438, NU6027, indisulam, JNJ.7706621, kenpaullone, abemaciclib, ribociclib, indirubin, R547, arcyriaflavin.a",0.798602875679548,0.260427655549908,FALSE
+"H1299","Pearson.est","CHK inhibitor",0.52934,1.5,0.0935,187,0.497,"SCH.900776, CHIR.124, LY2603618, LY2606368",1.02918838912748,0.303643611266668,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",-0.30719,-0.758,0.763,921,0.915,"metoxibutropate, indoprofen, curcumin, FK.3311, tepoxalin, piroxicam, pterostilbene, naproxen, aspirin, FR.122047, tryptanthrin",0.11747546204512,0.0385789059335517,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",0.35685,1.02,0.367,178,0.519,"PF.4981517, morin, eplerenone",0.435333935747911,0.284832642151542,FALSE
+"H1299","Pearson.est","DNA alkylating agent",-0.37621,-0.905,0.571,855,0.893,"temozolomide, ifosfamide, streptozotocin, carmustine, carboplatin, cyclophosphamide, melphalan, satraplatin, mitomycin.c",0.243363891754152,0.0491485411114536,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.43159,-1.06,0.399,934,0.804,"oxaliplatin, carmustine, valrubicin, carboplatin, metronidazole, tirapazamine, pibenzimol, melphalan, primaquine, mechlorethamine",0.399027104313252,0.0947439512515487,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",-0.40118,-0.973,0.492,1060,0.836,"fdcyd, RG108, disulfiram",0.30803489723264,0.0777937225609836,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",-0.29744,-0.718,0.809,890,0.903,"idoxuridine, foscarnet, cidofovir, trifluridine",0.0920514783877277,0.0443122496864942,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",-0.34056,-0.806,0.723,704,0.933,"floxuridine, cisplatin, cyclocytidine, azodicarbonamide, estramustine.phosphate, artesunate, anisomycin, altretamine, CB.10.277, enocitabine, mitomycin.c",0.140861702705469,0.0301183562535,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",-0.43672,-1.05,0.401,1187,0.778,"nemonapride, paliperidone, UH.232...., lurasidone, mesoridazine",0.396855627379818,0.109020403010311,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",0.44188,1.28,0.194,39,0.638,"PPT, levonorgestrel",0.712198270069774,0.195179321278838,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.65624,-1.58,0.0422,1238,0.771,"toremifene, danazol, fulvestrant",1.37468754903833,0.112945621949043,FALSE
+"H1299","Pearson.est","FGFR inhibitor",-0.55111,-1.32,0.158,1127,0.568,"PD.173074, MK.2461, lenvatinib, erdafitinib, lucitanib",0.801342913045577,0.245651664288981,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.62995,-1.53,0.0555,964,0.535,"midostaurin, TG.02, lestaurtinib, pacritinib, sunitinib, tandutinib, KW.2449, TG.101348, ENMD.2076, ponatinib, GTP.14564, sorafenib, quizartinib, tozasertib",1.25570701687732,0.271646217978772,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",0.37584,1.09,0.327,258,0.655,"hydrocortisone, betamethasone, fluorometholone, methylprednisolone, fluocinolone.acetonide, triamcinolone.acetonide, ciclesonide, halcinonide, desonide",0.485452247339714,0.183758700008217,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.30568,0.871,0.599,162,0.63,"SIB.1757, latrepirdine, kynurenic.acid, CGP.37849",0.222573177610689,0.200659450546418,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.56931,-1.38,0.1,1215,0.515,"LY2090314, GSK.3.inhibitor.IX, kenpaullone, CHIR.98014, indirubin",1,0.288192770958809,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",-0.53339,-1.3,0.145,913,0.528,"GSK1904529A, AZD3463, lestaurtinib, GSK1838705A, GW.441756",0.838631997765025,0.277366077466188,FALSE
+"H1299","Pearson.est","HCV inhibitor",-0.25735,-0.627,0.902,1291,0.949,"narlaprevir",0.0447934624580583,0.0227337875727074,FALSE
+"H1299","Pearson.est","HDAC inhibitor",-0.57037,-1.4,0.104,1075,0.499,"PCI.24781, entinostat, scriptaid, panobinostat, dacinostat, AR.42, trichostatin.a, givinostat, vorinostat, RG2833, resminostat, R306465, M.344, RGFP966",0.98296666070122,0.30189945437661,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",-0.25117,-0.618,0.934,998,0.941,"cyproheptadine, tecastemizole, BF2.649, lafutidine, epinastine",0.0296531237699066,0.0264103765727431,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",-0.26443,-0.646,0.887,1033,0.947,"fluvastatin, lovastatin",0.0520763801682736,0.0236500209967266,FALSE
+"H1299","Pearson.est","HSP inhibitor",0.42534,1.22,0.21,307,0.555,"BIIB021, KW.2478, SNX.2112, SNX.5422, alvespimycin, NVP.AUY922, ganetespib, VER.49009",0.677780705266081,0.255707016877324,FALSE
+"H1299","Pearson.est","JAK inhibitor",-0.38867,-0.934,0.542,989,0.854,"LY2784544, TG.02, AZD1480, lestaurtinib, pacritinib, TG.101348, AT.9283, TG.101209, tozasertib",0.266000713461613,0.068542129310995,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.40371,-0.983,0.497,1112,0.837,"sunitinib, tandutinib, lenvatinib, imatinib, sorafenib, KI.8751, masitinib",0.303643611266668,0.07727454200674,FALSE
+"H1299","Pearson.est","MDM inhibitor",-0.63653,-1.54,0.0485,1223,0.605,"serdemetan, RITA",1.31425826139774,0.218244625347531,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.61207,1.79,0.027,201,0.485,"selumetinib, trametinib, AS.703026, Ro.4987655, MEK1.2.inhibitor, cobimetinib, AZD8330, TAK.733, PD.198306, PD.0325901",1.56863623584101,0.314258261397736,FALSE
+"H1299","Pearson.est","MET inhibitor",-0.60239,-1.45,0.0782,1377,0.503,"NVP.BVU972, AMG458",1.10679324694015,0.298432014944073,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.29532,-0.728,0.826,846,0.923,"cabazitaxel, colchicine, estramustine.phosphate, D.64131",0.0830199526796178,0.0347982989740879,FALSE
+"H1299","Pearson.est","mTOR inhibitor",-0.42663,-1.03,0.43,720,0.78,"deforolimus, NVP.BEZ235, PF.05212384, OSI.027, voxtalisib, AZD8055, WYE.125132, PKI.179, torin.2, MLN0128, sirolimus, LY3023414, torin.1, PF.04691502, XL388, LY303511, GSK2126458, ku.0063794, WYE.354, SB.2343, AZD2014",0.366531544420413,0.10790539730952,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.3907,-0.937,0.557,1378,0.869,"betulinic.acid, EVP4593",0.254144804826271,0.0609802235513335,FALSE
+"H1299","Pearson.est","opioid receptor agonist",-0.32585,-0.796,0.736,714,0.93,"ADL5859, salvinorin.a, trimebutine, cebranopadol",0.133122185662501,0.0315170514460649,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",-0.48156,-1.15,0.293,893,0.663,"TAK.715, talmapimod, SB.242235, SB.239063, skepinone.l",0.533132379645891,0.178486471595227,FALSE
+"H1299","Pearson.est","PARP inhibitor",-0.62871,-1.5,0.0713,1185,0.478,"AG.14361, PJ.34, E7449, niraparib",1.14691047014813,0.320572103387881,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45659,-1.1,0.357,1080,0.736,"linifanib, sunitinib, crenolanib, tandutinib, axitinib, lenvatinib, imatinib, ponatinib, sorafenib, KI.8751, masitinib",0.447331783887807,0.133122185662501,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.40751,-0.991,0.475,1012,0.841,"BVT.948, CID.5458317, alexidine, GSK2830371",0.323306390375133,0.0752040042020878,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",0.3491,0.97,0.468,946,0.523,"cilostamide, EMD.53998, enoximone, avanafil, anagrelide, papaverine, zardaverine, trequinsin, GSK256066, YM.976",0.329754146925876,0.281498311132726,FALSE
+"H1299","Pearson.est","PI3K inhibitor",-0.36473,-0.884,0.627,850,0.914,"PI3K.IN.2, YM.201636, TG.100713, PKI.179, BGT226, AZD6482, LY3023414, PF.04691502, LY303511, GDC.0941, GSK2126458, CH5132799, CUDC.907, SB.2343",0.202732459169284,0.0390538042661686,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.39669,-0.963,0.517,701,0.835,"GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib, GW.843682X",0.286509456906058,0.0783135245163979,FALSE
+"H1299","Pearson.est","potassium channel blocker",0.34636,1.02,0.429,144,0.519,"dofetilide, mepivacaine",0.367542707815276,0.284832642151542,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",-0.31593,-0.771,0.75,877,0.931,"GW.501516, pterostilbene",0.1249387366083,0.0310503190186574,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.34016,-0.828,0.698,1323,0.935,"melengestrol.acetate, danazol",0.156144577376839,0.0291883891274822,FALSE
+"H1299","Pearson.est","proteasome inhibitor",0.36132,1.05,0.367,107,0.555,"MG.132, carfilzomib",0.435333935747911,0.255707016877324,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.29467,-0.719,0.813,1246,0.918,"thiostrepton, florfenicol, azomycin..2.nitroimidazole.",0.0899094544059319,0.0371573187987575,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.32649,-0.787,0.749,1070,0.925,"NVP.TAE226, BMS.599626, mubritinib",0.125518182300534,0.0338582672609674,FALSE
+"H1299","Pearson.est","RAF inhibitor",-0.30453,-0.746,0.771,1336,0.915,"sorafenib, TAK.632",0.112945621949043,0.0385789059335517,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.3392,-0.823,0.687,1112,0.924,"sunitinib, cabozantinib, sorafenib",0.16304326294045,0.0343280287798933,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",-0.64042,-1.55,0.0549,1290,0.708,"adapalene, fenretinide, bexarotene",1.26042765554991,0.149966742310231,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.35204,-0.846,0.658,947,0.923,"clofarabine, fludarabine, cladribine, pentostatin",0.181774106386044,0.0347982989740879,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",-0.60398,-1.48,0.0667,1257,0.475,"ipsapirone, aripiprazole",1.17587416608345,0.323306390375133,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",-0.54234,-1.32,0.136,1379,0.568,"lurasidone, aripiprazole",0.866461091629782,0.245651664288981,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.45029,-1.1,0.347,1248,0.736,"quinidine, triamterene, ajmaline, lappaconite",0.459670525209126,0.133122185662501,FALSE
+"H1299","Pearson.est","src inhibitor",0.40397,1.23,0.201,7,0.627,"dasatinib, saracatinib",0.696803942579511,0.202732459169284,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.5831,-1.41,0.0973,1004,0.513,"terconazole, ketoconazole",1.01188715973165,0.289882634888184,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",-0.31274,-0.762,0.792,1343,0.927,"adaprev",0.101274818410506,0.0329202658555029,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",0.36479,1.06,0.336,184,0.588,"capecitabine, doxifluridine, ftorafur",0.473660722610156,0.230622673923862,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.42285,-1.03,0.441,939,0.78,"beta.lapachone, camptothecin, nemorubicin, valrubicin, etoposide.phosphate, fleroxacin, voreloxin, rubitecan, SN.38, dexrazoxane, genz.644282, TAS.103, irinotecan",0.355561410532161,0.10790539730952,FALSE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.15773,-0.38,0.997,831,0.998,"indibulin, flubendazole, albendazole, plinabulin, nocodazole, ABT.751, docetaxel, epothilone.d, KX2.391",0.00130484168834428,0.000869458712628891,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",-0.27468,-0.664,0.883,1070,0.946,"NVP.TAE226, sunitinib, BMS.599626, cabozantinib, mubritinib, GTP.14564, sorafenib, UNC2250",0.0540392964224314,0.0241088635982073,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.3491,-0.848,0.685,1080,0.94,"linifanib, sunitinib, cabozantinib, PD.173074, MK.2461, RAF265, axitinib, lenvatinib, ENMD.2076, MGCD.265, sorafenib, tivozanib, lucitanib, KI.8751",0.164309428507574,0.0268721464003014,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",-0.51182,-1.26,0.194,1175,0.521,"maxacalcitol, paricalcitol, tacalcitol",0.712198270069774,0.283162276700476,FALSE
diff --git a/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren.met/DMEA/DMEA_venn_diagram.pdf
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diff --git a/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_correlation_matrix.pdf b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_correlation_matrix.pdf
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diff --git a/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_interactive_network.graph.html b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_interactive_network.graph.html
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--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-88e65af1ec95b6c84a61" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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diff --git a/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..291c61e
--- /dev/null
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+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"estrogen receptor antagonist",0.8851,1.14384832424972,0.00170439338368609,"HCC827, HCC95, H1650, H2009, H2126, H3255, H1299, H1703, H460, H520",10,3,"HCC827, HCC95, H1299",0.0113464066409016
+"KIT inhibitor",0.839466666666667,0.803198326928631,0.19121708254354,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.307447073893535
+"PDGFR tyrosine kinase receptor inhibitor",0.8026,0.784486711168519,0.357883032418245,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.481088666529444
+"microtubule inhibitor",0.770533333333333,0.903426008249127,0.114816218863349,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.208310356372865
+"FLT3 inhibitor",0.677733333333333,0.959667983260481,0.137914163518786,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.23079513078654
+"VEGFR inhibitor",0.595733333333333,0.863282809700164,0.607982672900286,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.744098196683932
+"RET tyrosine kinase inhibitor",0.573428571428571,1.32970243717479,0.0239655681574714,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"H2009, H3255",0.0701848781754521
+"tyrosine kinase inhibitor",0.556133333333333,0.869785841183799,0.690775001579834,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.820596210897299
+"vitamin D receptor agonist",0.549642857142857,1.36886952837525,0.0475892932624293,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1299, H1703, H460, H520",14,2,"H2126, H1299",0.118252183258158
+"phosphatase inhibitor",0.4786,1.01344094196808,0.325808489249211,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.446884199423928
+"FGFR inhibitor",0.4696,1.13571467744827,0.120120437869359,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.209571827772073
+"histamine receptor antagonist",0.416133333333333,0.951023198355079,0.67544344869976,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.81450533519677
+"ATPase inhibitor",0.411533333333333,1.17289342267419,0.0385494299994575,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.105368441998517
+"tubulin polymerization inhibitor",0.402333333333333,1.32053661531248,0.00227791502989198,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H2009",0.0133420737465102
+"cytochrome P450 inhibitor",0.393076923076923,1.35978763424897,0.00344947591532525,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H520",13,1,"H358",0.018857135003778
+"CC chemokine receptor antagonist",0.3636,1.07077720771943,0.326988438602874,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.446884199423928
+"androgen receptor antagonist",0.329,1.55017123478113,0.000888251145708769,"HCC827, HCC95, H1650, H2126, A549, HCC15, H460, H520",8,1,"H520",0.00809295488312434
+"acetylcholine receptor agonist",0.317272727272727,1.21997853185284,0.0830351587096072,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, H1703, H460, H520",11,0,"",0.174586743953533
+"MET inhibitor",0.299642857142857,1.35854920395267,0.00456728950628658,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"H3255, H520",0.0234073587197187
+"RAF inhibitor",0.279333333333333,1.18965196991549,0.0897258113656997,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.179451622731399
+"PI3K inhibitor",0.269933333333333,0.873835753336703,0.970160276568316,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.994414283482524
+"acetylcholine receptor antagonist",0.255583333333333,1.46268218497472,0.000574967513496775,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, H1703, H460, H520",12,2,"HCC827, H520",0.00667744342406333
+"HCV inhibitor",0.252333333333333,1.66280977063924,0.0404494935445278,"HCC95, H1650, H2126",3,1,"H2126",0.106995434537138
+"Bcr.Abl kinase inhibitor",0.242866666666667,1.31318608553323,0.00946312735091422,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.0369512591797603
+"CDK inhibitor",0.2346,1.05436018513599,0.515173034480734,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.643245580591472
+"protein tyrosine kinase inhibitor",0.2198,1.28920120340354,0.0150872673834341,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0526342477945311
+"phosphodiesterase inhibitor",0.215866666666667,1.18091767383715,0.103406399754913,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC827",0.192711926815974
+"protein synthesis inhibitor",0.215666666666667,1.1380993972827,0.223548542544777,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.345867556390032
+"Abl kinase inhibitor",0.211666666666667,1.19977745952362,0.0967920359681462,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2009",0.184580161613674
+"AKT inhibitor",0.202066666666667,1.11403984711157,0.294622577041667,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.431411630668156
+"sodium channel blocker",0.202066666666667,0.997834259546048,0.76415742175529,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.829002800604204
+"Aurora kinase inhibitor",0.193466666666667,1.39324604875842,0.000651457895030568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, HCC15",0.00667744342406333
+"JAK inhibitor",0.1906,1.05944829308196,0.517734247793136,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.643245580591472
+"PPAR receptor agonist",0.180333333333333,1.15114551643135,0.324169860550375,"HCC827, HCC95, H1650, H1975, H2126, H3255, A549, HCC15, H520",9,0,"",0.446884199423928
+"topoisomerase inhibitor",0.174133333333333,1.22948914284794,0.0374414601257941,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2009, H520",0.105368441998517
+"thymidylate synthase inhibitor",0.172666666666667,1.33068755947908,0.00683375180867201,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0311315360172836
+"proteasome inhibitor",0.1566,1.66280661189792,0.0004488483204824,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,6,"H1650, H2009, H2126, HCC15, HCC44, H520",0.00613426037992614
+"calcium channel blocker",0.1564,1.00755147333949,0.749350522627746,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.829002800604204
+"adrenergic receptor agonist",0.156066666666667,1.01618062698846,0.738996105873,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.829002800604204
+"adrenergic receptor antagonist",0.1464,0.96060968734891,0.876466860201191,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.933380292681788
+"retinoid receptor agonist",0.142733333333333,1.49692625386951,0.00113915341974756,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC827, H1650, H460",0.00849187094720905
+"HDAC inhibitor",0.140933333333333,1.19780826432916,0.116857029184778,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.208310356372865
+"glutamate receptor antagonist",0.1316,1.03153331086716,0.717593262624976,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.820596210897299
+"DNA polymerase inhibitor",0.121133333333333,1.11883203556634,0.281802030716572,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.42014120943198
+"p38 MAPK inhibitor",0.112133333333333,1.28435085697387,0.0197801780415804,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.0623836384388304
+"dopamine receptor antagonist",0.104066666666667,1.00620961084278,0.768344059096579,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.829002800604204
+"NFkB pathway inhibitor",0.101266666666667,1.01840796390856,0.720523502251287,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.820596210897299
+"estrogen receptor agonist",0.0958666666666666,1.23278105266488,0.0539026687462208,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.130000554035003
+"growth factor receptor inhibitor",0.0930714285714285,1.33328117320136,0.00758242775850614,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"HCC95, H1975",0.0327241619051318
+"PARP inhibitor",0.0758,1.31580698758269,0.0105458707427728,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0393073364048803
+"progesterone receptor agonist",0.0749333333333334,1.22358387339736,0.0602338598054067,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.141119328686953
+"sterol demethylase inhibitor",0.0470769230769232,1.44773653574229,0.000410104063120403,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1299, H1703, H520",13,4,"HCC827, HCC95, H1975, H2126",0.00613426037992614
+"DNA inhibitor",0.0252666666666666,0.926540220903756,0.959470890947323,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.994414283482524
+"adenosine receptor antagonist",0.0247142857142857,1.360399004171,0.00654636876144202,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"H358, H520",0.0311315360172836
+"opioid receptor agonist",0.0243076923076923,1.22585401418871,0.088645632297815,"HCC827, HCC95, H1650, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",13,0,"",0.179451622731399
+"cyclooxygenase inhibitor",0.0159333333333333,0.877131157049313,0.993011081052835,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.995803359462341
+"ribonucleotide reductase inhibitor",0,1.08591001995035,0.50378480371297,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.643245580591472
+"DNA alkylating agent",-0.0186666666666666,0.858306028229581,0.995803359462341,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.995803359462341
+"mTOR inhibitor",-0.0252666666666666,1.09878448859681,0.454162966796078,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.591132750432991
+"serotonin receptor antagonist",-0.0269333333333333,0.911887717607716,0.957515272450734,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.994414283482524
+"ALK tyrosine kinase receptor inhibitor",-0.0446666666666667,1.16079736552489,0.25201862318328,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.382694946315351
+"glycogen synthase kinase inhibitor",-0.0522,1.21404366831322,0.0961651329110097,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.184580161613674
+"PLK inhibitor",-0.0701333333333333,1.52403969139664,0.000999606405274106,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,4,"HCC95, H2009, H460, H520",0.00819677252324767
+"MDM inhibitor",-0.0708000000000001,1.66942363972986,1.56270817326498e-05,"HCC827, HCC95, H1650, H1975, H2126, H3255, A549, HCC15, H1703, H520",10,4,"HCC95, H1650, A549, HCC15",0.000640710351038642
+"benzodiazepine receptor agonist",-0.0820666666666666,1.02639072667748,0.707471534520014,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.820596210897299
+"BCL inhibitor",-0.0991333333333333,1.1177867076547,0.321780236635162,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.446884199423928
+"src inhibitor",-0.103733333333333,1.27221451844898,0.0233276406645266,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC95",0.0701848781754521
+"DNA synthesis inhibitor",-0.113333333333333,1.08893904241479,0.419663100419937,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.555038294103788
+"DNA methyltransferase inhibitor",-0.117923076923077,1.18734714535798,0.206687310061696,"HCC827, HCC95, H1650, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",13,1,"H1650",0.325929988943443
+"TGF beta receptor inhibitor",-0.134428571428571,1.47191124911617,4.93800000911267e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,2,"H2126, HCC15",0.0010122900018681
+"antioxidant",-0.154461538461539,1.47953413925829,0.00930092235482115,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, HCC15, H1299, H1703, H460, H520",13,3,"HCC95, H358, H1299",0.0369512591797603
+"EGFR inhibitor",-0.168266666666667,1.29604301442433,0.0192857874899016,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0623836384388304
+"HMGCR inhibitor",-0.237428571428571,1.72200288977137,0.075956984258917,"HCC95, H1650, H2126, A549, HCC15, H1703, H460",7,2,"HCC95, A549",0.163907176558716
+"bacterial DNA gyrase inhibitor",-0.255428571428571,1.13860776756162,0.17306815712699,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1703, H460, H520",14,1,"H1703",0.283831777688264
+"bacterial 50S ribosomal subunit inhibitor",-0.304466666666667,1.12757558293806,0.133955195667609,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.228840125932165
+"bromodomain inhibitor",-0.314769230769231,1.50190352296933,3.03863454928732e-05,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, HCC44, H1703, H460, H520",13,4,"HCC95, HCC15, H1703, H520",0.000830560110138535
+"glucocorticoid receptor agonist",-0.3748,1.2018185149419,0.041973067144815,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.107555984558588
+"MEK inhibitor",-0.406666666666667,1.33239942888581,0.00179882056502098,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC95, H1703",0.0113464066409016
+"AP inhibitor",-0.482846153846154,1.63842718514606,2.24458832074295e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, H1299, H1703, H460, H520",13,5,"HCC95, H1975, H2126, A549, H460",1.84056242300922e-05
+"HSP inhibitor",-0.5138,1.11503089002695,0.0733558848355029,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"HCC95, HCC44, H520",0.162572501527331
+"potassium channel blocker",-0.621,1.06096756869293,0.0651150256396577,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, A549, HCC15, H1703, H460, H520",12,0,"",0.148317558401442
+"CHK inhibitor",-0.700214285714286,1.34756236782007,0.0154051456959603,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, H1299, H1703, H460, H520",14,4,"HCC95, H1650, H2126, A549",0.0526342477945311
diff --git a/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..a6fe0fd
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_results.csv
@@ -0,0 +1,1156 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"HCC827","Pearson.est","EGFR inhibitor",-0.58091,-1.56,0.0895,1183,0.46,"neratinib, CGP.52411, BMS.599626, GW.583340, OSI.420, PD.153035, PD.168393, CNX.2006, tucatinib, afatinib, poziotinib, BMS.690514, CP.724714, erlotinib, gefitinib, XL.647, lapatinib, canertinib, AZD8931, pelitinib, dacomitinib, rociletinib",1.04817696468409,0.337242168318426,FALSE
+"HCC827","Pearson.est","Abl kinase inhibitor",-0.19255,-0.518,0.959,274,0.971,"imatinib, GZD824, tozasertib, bafetinib, ponatinib, flumatinib, nilotinib, dasatinib, KW.2449, bosutinib, metatinib, ZM.306416",0.0181813928293364,0.0127807700919951,FALSE
+"HCC827","Pearson.est","acetylcholine receptor agonist",0.44648,1.18,0.254,33,0.853,"tremorine",0.595166283380062,0.069050968832477,FALSE
+"HCC827","Pearson.est","acetylcholine receptor antagonist",0.67072,1.8,0.0166,156,0.2,"darifenacin, dicycloverine",1.77989191195995,0.698970004336019,TRUE
+"HCC827","Pearson.est","adenosine receptor antagonist",-0.43307,-1.15,0.275,1208,0.771,"sulmazole, CGS.15943",0.560667306169737,0.112945621949043,FALSE
+"HCC827","Pearson.est","adrenergic receptor agonist",0.14296,0.38,1,1232,0.999,"xylazine, buphenine, isoetharine, epinephrine, norepinephrine, methyldopa, ritodrine, oxymetazoline, A61603, midodrine, terbutaline, isoxsuprine, clenbuterol, lidamidine, metaraminol",0,0.000434511774017692,FALSE
+"HCC827","Pearson.est","adrenergic receptor antagonist",-0.29568,-0.807,0.655,1261,0.884,"pindolol, propranolol, dronedarone, prazosin",0.183758700008217,0.0535477349869269,FALSE
+"HCC827","Pearson.est","AKT inhibitor",-0.2281,-0.62,0.91,1133,0.925,"MK.2206, palomid.529, A.674563",0.0409586076789064,0.0338582672609674,FALSE
+"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25945,-0.711,0.782,1153,0.981,"crizotinib, AP26113, AZD3463, GW.788388",0.106793246940152,0.0083309926200515,FALSE
+"HCC827","Pearson.est","androgen receptor antagonist",0.53691,1.45,0.0898,455,0.74,"flutamide, RU.58841, nilutamide, enzalutamide",1.0467236633327,0.130768280269024,FALSE
+"HCC827","Pearson.est","antioxidant",-0.23243,-0.629,0.881,919,0.968,"benfotiamine, chlorogenic.acid, mesna, trolox",0.0550240915879521,0.0141246426916063,FALSE
+"HCC827","Pearson.est","AP inhibitor",0.35568,0.945,0.485,15,1,"idronoxil",0.314258261397736,0,FALSE
+"HCC827","Pearson.est","ATPase inhibitor",0.40984,1.09,0.354,450,0.962,"blebbistatin...., digitoxigenin, oligomycin.a, evodiamine, rabeprazole",0.450996737974212,0.0168249279621871,FALSE
+"HCC827","Pearson.est","Aurora kinase inhibitor",-0.30848,-0.85,0.599,928,0.87,"PHA.680632, danusertib, KW.2449, CYC116, ZM.447439, MLN.8054, GSK1070916, MK.5108, TAK.901, PF.03814735, AT.9283, CCT129202",0.222573177610689,0.0604807473813815,FALSE
+"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.53637,-1.48,0.104,1198,0.539,"radezolid, valnemulin, azalomycin.b, tilmicosin, tedizolid",0.98296666070122,0.268411234813261,FALSE
+"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.31663,-0.854,0.587,1221,0.895,"trovafloxacin, nadifloxacin",0.231361898752386,0.048176964684088,FALSE
+"HCC827","Pearson.est","BCL inhibitor",-0.41157,-1.13,0.285,1233,0.764,"navitoclax, TW.37, HA14.1",0.54515513999149,0.11690664142431,FALSE
+"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",0.33056,0.89,0.561,539,0.958,"imatinib, GZD824, tozasertib, bafetinib, ponatinib, flumatinib",0.251037138743839,0.0186344909214556,FALSE
+"HCC827","Pearson.est","benzodiazepine receptor agonist",0.27498,0.709,0.791,338,1,"piperazine, eprinomectin, bentazepam, CL.218872",0.101823516502323,0,FALSE
+"HCC827","Pearson.est","bromodomain inhibitor",0.3364,0.906,0.537,550,0.962,"I.BET151, PFI.1, JQ1....",0.270025714300444,0.0168249279621871,FALSE
+"HCC827","Pearson.est","calcium channel blocker",-0.23172,-0.624,0.935,1413,0.946,"fendiline",0.0291883891274822,0.0241088635982073,FALSE
+"HCC827","Pearson.est","CC chemokine receptor antagonist",0.37793,0.989,0.434,347,1,"SB.225002, UNBS.5162, PF.04136309",0.362510270487489,0,FALSE
+"HCC827","Pearson.est","CDK inhibitor",-0.45914,-1.23,0.213,960,0.778,"arcyriaflavin.a, indisulam, BMS.265246, P276.00, PHA.793887, kenpaullone, aminopurvalanol.a, BMS.387032, AT.7519, R547, indirubin, CR8..R.",0.671620396561262,0.109020403010311,FALSE
+"HCC827","Pearson.est","CHK inhibitor",-0.50086,-1.36,0.166,1093,0.633,"LY2606368, CHIR.124, AZD7762, LY2603618",0.779891911959945,0.198596289982645,FALSE
+"HCC827","Pearson.est","cyclooxygenase inhibitor",0.35539,0.933,0.53,339,0.987,"naproxen, piroxicam, amfenac, tepoxalin, aspirin, AM.404, suxibuzone, metoxibutropate, acetylsalicylsalicylic.acid, curcumin",0.275724130399211,0.00568284733036327,FALSE
+"HCC827","Pearson.est","cytochrome P450 inhibitor",0.49714,1.34,0.166,482,0.66,"clotrimazole, cobicistat, metyrapone, eplerenone",0.779891911959945,0.180456064458131,FALSE
+"HCC827","Pearson.est","DNA alkylating agent",0.32822,0.852,0.65,313,1,"cisplatin, TH.302, dianhydrogalactitol, carmustine, estramustine, cyclophosphamide, carboplatin",0.187086643357144,0,FALSE
+"HCC827","Pearson.est","DNA inhibitor",0.2113,0.555,0.952,199,1,"carmustine, tirapazamine, mechlorethamine",0.0213630516155257,0,FALSE
+"HCC827","Pearson.est","DNA methyltransferase inhibitor",-0.33493,-0.895,0.544,1422,0.847,"fdcyd",0.26440110030182,0.0721165896692931,FALSE
+"HCC827","Pearson.est","DNA polymerase inhibitor",0.26901,0.713,0.796,369,1,"cidofovir, famciclovir, foscarnet",0.0990869322623309,0,FALSE
+"HCC827","Pearson.est","DNA synthesis inhibitor",0.48775,1.31,0.154,160,0.667,"cisplatin, azodicarbonamide, artesunate, nelarabine, estramustine.phosphate",0.812479279163537,0.175874166083451,FALSE
+"HCC827","Pearson.est","dopamine receptor antagonist",0.26614,0.706,0.824,505,1,"lurasidone, isofloxythepin, UH.232...., amisulpride, raclopride, sertindole, acetophenazine",0.0840727883028842,0,FALSE
+"HCC827","Pearson.est","estrogen receptor agonist",0.50455,1.36,0.116,161,0.765,"equol, ethinyl.estradiol, estradiol.cypionate",0.935542010773082,0.116338564846382,FALSE
+"HCC827","Pearson.est","estrogen receptor antagonist",0.70625,1.91,0.00727,287,0.184,"toremifene, tamoxifen, fulvestrant, raloxifene",2.13846558914096,0.735182176990464,TRUE
+"HCC827","Pearson.est","FGFR inhibitor",-0.29486,-0.801,0.692,1083,0.865,"nintedanib, PD.173074, orantinib, AZD4547, MK.2461",0.159893905543242,0.0629838925351858,FALSE
+"HCC827","Pearson.est","FLT3 inhibitor",0.31868,0.85,0.632,502,0.969,"tyrphostin.AG.1296, dovitinib, ENMD.2076, sunitinib, tozasertib, gilteritinib, TG.101348, TG.02, ponatinib, sorafenib",0.199282921717615,0.0136762229492347,FALSE
+"HCC827","Pearson.est","glucocorticoid receptor agonist",-0.24382,-0.653,0.86,1365,0.969,"rimexolone, methylprednisolone, deflazacort",0.0655015487564323,0.0136762229492347,FALSE
+"HCC827","Pearson.est","glutamate receptor antagonist",0.37034,0.967,0.479,274,1,"latrepirdine, felbamate, IEM1754, diazooxonorleucine, MTPG",0.319664486585437,0,FALSE
+"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.69535,-1.91,0.011,1089,0.42,"kenpaullone, AZD2858, CHIR.99021, indirubin, CHIR.98014",1.95860731484178,0.3767507096021,FALSE
+"HCC827","Pearson.est","growth factor receptor inhibitor",-0.43109,-1.19,0.25,1176,0.802,"lestaurtinib, GSK1904529A, AZD3463",0.602059991327962,0.0958256317158365,FALSE
+"HCC827","Pearson.est","HDAC inhibitor",-0.45562,-1.24,0.228,1068,0.832,"chidamide, panobinostat, R306465, belinostat, pyroxamide, scriptaid, RG2833, givinostat, SB.939, JNJ.26481585, entinostat, mocetinostat, tacedinaline, resminostat",0.642065152999546,0.0798766737092761,FALSE
+"HCC827","Pearson.est","histamine receptor antagonist",0.41266,1.12,0.299,443,0.944,"chloropyramine, tiotidine, cyproheptadine, cimetidine, famotidine, lafutidine, tecastemizole, epinastine, nizatidine, BF2.649, terfenadine",0.52432881167557,0.025028005701931,FALSE
+"HCC827","Pearson.est","HSP inhibitor",-0.39156,-1.03,0.399,1346,0.841,"XL888, KW.2478, tanespimycin",0.399027104313252,0.0752040042020878,FALSE
+"HCC827","Pearson.est","JAK inhibitor",-0.36523,-0.992,0.435,1088,0.759,"WHI.P154, pacritinib, PRT062070, TG.101209, lestaurtinib, AT.9283, baricitinib",0.361510743045363,0.11975822410452,FALSE
+"HCC827","Pearson.est","KIT inhibitor",0.25641,0.665,0.87,312,1,"motesanib, imatinib, masitinib, regorafenib, sunitinib",0.0604807473813815,0,FALSE
+"HCC827","Pearson.est","MDM inhibitor",0.28041,0.752,0.739,459,1,"idasanutlin, nutlin.3, AMG.232",0.131355561605174,0,FALSE
+"HCC827","Pearson.est","MEK inhibitor",-0.35688,-0.991,0.453,986,0.728,"MEK162, AZD8330, Ro.4987655, PD.318088, TAK.733, U.0126, refametinib, PD.184352, arctigenin",0.343901797987168,0.137868620686963,FALSE
+"HCC827","Pearson.est","MET inhibitor",-0.58165,-1.57,0.0763,1099,0.533,"PF.04217903, AMG458, LY2801653, INC.280",1.11747546204512,0.273272790973428,FALSE
+"HCC827","Pearson.est","microtubule inhibitor",0.38674,1.03,0.397,472,1,"estramustine.phosphate, triclabendazole, D.64131, vinflunine, colchicine, vinblastine, secnidazole",0.401209493236885,0,FALSE
+"HCC827","Pearson.est","mTOR inhibitor",-0.23651,-0.656,0.881,1239,1,"AZD8055, palomid.529, LY3023414, XL388, WYE.125132",0.0550240915879521,0,FALSE
+"HCC827","Pearson.est","NFkB pathway inhibitor",0.2226,0.578,0.931,531,1,"parthenolide...., curcumin, bindarit, BAY.11.7082, EVP4593, betulinic.acid",0.0310503190186574,0,FALSE
+"HCC827","Pearson.est","opioid receptor agonist",-0.38947,-1.03,0.415,1031,0.841,"ADL5859, spiradoline, salvinorin.a",0.381951903287907,0.0752040042020878,FALSE
+"HCC827","Pearson.est","p38 MAPK inhibitor",0.35827,0.953,0.491,365,1,"SB.242235, skepinone.l, CMPD.1",0.308918507877032,0,FALSE
+"HCC827","Pearson.est","PARP inhibitor",0.30269,0.797,0.694,465,1,"AZD2461, PJ.34, niraparib, AG.14361",0.158640529545145,0,FALSE
+"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.19075,0.507,0.967,502,1,"dovitinib, motesanib, imatinib, masitinib, regorafenib, sunitinib, lenvatinib, linifanib, ponatinib, sorafenib",0.0145735259169983,0,FALSE
+"HCC827","Pearson.est","phosphatase inhibitor",0.50091,1.35,0.163,412,0.706,"CID.5458317, bis.maltolato.oxovanadium.IV., GSK2830371, alexidine, BVT.948, mycophenolate.mofetil, sodium.stibogluconate",0.787812395596042,0.151195298948196,FALSE
+"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.72191,-1.9,0.00842,1260,0.226,"avanafil, papaverine, EMD.53998, GSK256066, cilostamide, YM.976",2.07468790850035,0.645891560852599,TRUE
+"HCC827","Pearson.est","PI3K inhibitor",-0.36476,-1.02,0.414,1107,0.817,"ZSTK.474, GSK2126458, CUDC.907, YM.201636, TG100.115, CH5132799, buparlisib, TG.100713, LY3023414, taselisib, alpelisib",0.382999658879101,0.0877779434675845,FALSE
+"HCC827","Pearson.est","PLK inhibitor",-0.62268,-1.67,0.0448,898,0.579,"GW.843682X, rigosertib, BI.2536, NMS.1286937, GSK461364, volasertib",1.34872198600186,0.237321436272564,FALSE
+"HCC827","Pearson.est","potassium channel blocker",-0.37411,-1.01,0.413,1132,0.796,"oleoylethanolamide, ML133",0.384049948343599,0.0990869322623309,FALSE
+"HCC827","Pearson.est","PPAR receptor agonist",-0.3649,-1,0.433,1132,0.778,"oleoylethanolamide, ciprofibrate, pterostilbene",0.363512103646635,0.109020403010311,FALSE
+"HCC827","Pearson.est","progesterone receptor agonist",0.286,0.755,0.736,51,1,"nomegestrol.acetate",0.133122185662501,0,FALSE
+"HCC827","Pearson.est","proteasome inhibitor",0.22296,0.587,0.938,464,1,"MG.132, oprozomib, ixazomib, ixazomib.citrate",0.0277971616209356,0,FALSE
+"HCC827","Pearson.est","protein synthesis inhibitor",0.2157,0.561,0.952,227,1,"chloramphenicol.palmitate, anguidine, azomycin..2.nitroimidazole., clindamycin.phosphate",0.0213630516155257,0,FALSE
+"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.38498,-1.03,0.413,1212,0.841,"BMS.599626, NVP.TAE226, AV.412, CP.724714",0.384049948343599,0.0752040042020878,FALSE
+"HCC827","Pearson.est","RAF inhibitor",0.46693,1.29,0.169,502,0.655,"SB.590885, vemurafenib, CEP.32496, regorafenib, AZ.628, dabrafenib, GDC.0879, sorafenib",0.772113295386326,0.183758700008217,FALSE
+"HCC827","Pearson.est","RET tyrosine kinase inhibitor",0.3353,0.909,0.555,312,0.997,"vandetanib, regorafenib, sunitinib",0.255707016877324,0.00130484168834428,FALSE
+"HCC827","Pearson.est","retinoid receptor agonist",0.74749,1.98,0.00542,219,0.219,"AM.580, adapalene, fenretinide, LE.135",2.26600071346161,0.659555885159882,TRUE
+"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.309,-0.823,0.67,1078,0.889,"triapine, gemcitabine, fludarabine",0.173925197299174,0.0510982390297863,FALSE
+"HCC827","Pearson.est","serotonin receptor antagonist",0.29447,0.804,0.679,441,1,"lurasidone, pirenperone, lerisetron, SB.200646, sertindole",0.168130225719498,0,FALSE
+"HCC827","Pearson.est","sodium channel blocker",0.53513,1.42,0.12,310,0.708,"oxcarbazepine, benzocaine, cibenzoline, butamben, ajmaline, brivaracetam",0.920818753952375,0.149966742310231,FALSE
+"HCC827","Pearson.est","src inhibitor",-0.60044,-1.61,0.0614,1308,0.567,"PP.1, ZM.306416, TG.100572, PP.2",1.21183162885883,0.246416941107093,FALSE
+"HCC827","Pearson.est","sterol demethylase inhibitor",0.70066,1.84,0.0192,296,0.205,"ketoconazole, terconazole, posaconazole, sulconazole",1.71669877129645,0.688246138944246,TRUE
+"HCC827","Pearson.est","TGF beta receptor inhibitor",0.60056,1.6,0.0425,230,0.464,"D.4476, adaprev, SB.431542",1.37161106994969,0.333482019445119,FALSE
+"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.43119,-1.17,0.26,941,0.783,"raltitrexed, trifluridine, ftorafur, doxifluridine",0.585026652029182,0.106238237942057,FALSE
+"HCC827","Pearson.est","topoisomerase inhibitor",0.203,0.539,0.967,523,1,"etoposide.phosphate, beta.lapachone, dexrazoxane, amsacrine, TAS.103, epirubicin, mitoxantrone, nemorubicin, amonafide, topotecan",0.0145735259169983,0,FALSE
+"HCC827","Pearson.est","tubulin polymerization inhibitor",0.40194,1.06,0.371,484,0.98,"taltobulin, flubendazole, dolastatin.10, nocodazole, KX2.391, combretastatin.A.4, CYT.997, oxibendazole, indibulin, vinblastine, epothilone.d, verubulin, vindesine",0.430626090384954,0.00877392430750515,FALSE
+"HCC827","Pearson.est","tyrosine kinase inhibitor",-0.23421,-0.654,0.871,1285,0.997,"NVP.TAE226, AMG.208, AV.412, cabozantinib, CP.724714",0.0599818449923368,0.00130484168834428,FALSE
+"HCC827","Pearson.est","VEGFR inhibitor",-0.34386,-0.94,0.502,1083,0.79,"nintedanib, PD.173074, vatalanib, KI.8751, golvatinib, orantinib, MK.2461, foretinib, ZM.306416, cabozantinib, BMS.690514, TG.100572, XL.647",0.299296282854981,0.102372908709559,FALSE
+"HCC827","Pearson.est","vitamin D receptor agonist",-0.51255,-1.38,0.143,1228,0.669,"tacalcitol, calcitriol, ercalcitriol",0.844663962534938,0.174573882232177,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",-0.57702,-1.51,0.0847,1076,0.28,"AST.1306, afatinib, tyrphostin.AG.494, poziotinib, erlotinib, canertinib, osimertinib, tyrphostin.AG.1478, vandetanib, rociletinib, tucatinib, BMS.690514, neratinib, dovitinib, TAK.285, WZ8040, WZ.4002, WZ.3146, AEE788, ARRY.334543, lapatinib, XL.647, GW.583340, gefitinib, CP.724714, dacomitinib, AZD8931, pelitinib",1.07211658966929,0.552841968657781,FALSE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.41747,-1.11,0.335,966,0.529,"tozasertib, GZD824, metatinib, ponatinib, imatinib, bosutinib, dasatinib",0.474955192963155,0.276544327964814,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",-0.39232,-1.04,0.399,1164,0.605,"oxiracetam, xanomeline",0.399027104313252,0.218244625347531,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.37871,-0.996,0.447,989,0.576,"diphemanil, iododexetimide, hyoscyamine",0.349692476868064,0.239577516576788,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",-0.39178,-1.03,0.408,843,0.586,"PSB.1115, theophylline, SCH.58261, CGS.15943",0.38933983691012,0.232102383981909,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",0.23639,0.696,0.824,422,0.945,"metaraminol, methyldopa, isoetharine, oxymetazoline, xylazine, ritodrine",0.0840727883028842,0.0245681914907371,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",-0.22449,-0.602,0.93,1092,0.915,"atenolol...., metoprolol, prazosin, RS.17053, practolol",0.0315170514460649,0.0385789059335517,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.47178,-1.22,0.256,1159,0.484,"CCT128930, triciribine, AZD5363, GDC.0068, GSK2110183, uprosertib",0.59176003468815,0.315154638355588,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.60228,-1.61,0.0538,886,0.26,"brigatinib, AZD3463, DMH1, crizotinib, alectinib, SB.505124, AP26113, NVP.TAE684, CEP.37440, GW.788388",1.26921772433361,0.585026652029182,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",0.5284,1.51,0.0829,508,0.275,"enzalutamide, RU.58841, bicalutamide",1.08144546944973,0.560667306169737,FALSE
+"HCC95","Pearson.est","antioxidant",0.61925,1.78,0.0396,421,0.146,"mesna, benfotiamine, trolox, chlorogenic.acid",1.40230481407449,0.835647144215563,TRUE
+"HCC95","Pearson.est","AP inhibitor",0.65109,1.88,0.0242,157,0.106,"tanshinone.i, LCL.161, birinapant, GDC.0152",1.61618463401957,0.97469413473523,TRUE
+"HCC95","Pearson.est","ATPase inhibitor",0.42317,1.22,0.216,191,0.576,"oligomycin.a, thonzonium, omeprazole, blebbistatin...., k.strophanthidin",0.665546248849069,0.239577516576788,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",-0.49804,-1.31,0.176,906,0.388,"PHA.680632, CCT129202, barasertib.HQPA, MK.8745, GSK1070916, tozasertib, AT.9283, MK.5108, AMG900, alisertib, aurora.a.inhibitor.i, PF.03814735, TAK.901, barasertib, danusertib, CCT137690",0.75448733218585,0.411168274405793,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.29052,0.826,0.65,433,0.873,"tilmicosin, josamycin, valnemulin, tedizolid",0.187086643357144,0.0589857562944303,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.60345,1.64,0.0803,363,0.217,"finafloxacin, novobiocin, sarafloxacin, sparfloxacin, norfloxacin",1.09528445472132,0.66354026615147,FALSE
+"HCC95","Pearson.est","BCL inhibitor",-0.46096,-1.22,0.237,1001,0.484,"HA14.1, ABT.737, obatoclax, navitoclax",0.625251653989896,0.315154638355588,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.52128,-1.39,0.155,966,0.386,"tozasertib, GZD824, metatinib, ponatinib, imatinib, bosutinib, dasatinib",0.809668301829709,0.413412695328245,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",0.3704,1.04,0.393,95,0.688,"lorazepam, temazepam, bentazepam",0.405607449624573,0.162411561764489,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",-0.72227,-1.87,0.0172,1187,0.143,"JQ1...., PFI.1, I.BET.762, OTX015",1.76447155309245,0.844663962534938,TRUE
+"HCC95","Pearson.est","calcium channel blocker",0.33097,0.938,0.49,243,0.81,"cinnarazine, SR.33805, fendiline, pranidipine",0.309803919971486,0.0915149811213502,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",0.359,1.05,0.357,373,0.71,"MK.0812, navarixin, PF.04136309",0.447331783887807,0.148741651280925,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.2923,-0.769,0.727,1248,0.815,"TG.02, PHA.848125, alvocidib, R547, abemaciclib",0.138465589140962,0.0888423912600234,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.65271,-1.73,0.0162,1056,0.189,"SCH.900776, PF.477736, LY2606368, CHIR.124, SB.218078",1.79048498545737,0.723538195826756,TRUE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",0.24102,0.694,0.805,110,0.914,"metoxibutropate, phenylbutazone, FR.122047",0.0942041196321315,0.0390538042661686,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",-0.54443,-1.45,0.109,962,0.342,"morin, PF.4981517, metyrapone",0.962573502059376,0.465973893943865,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.33084,-0.887,0.576,1275,0.692,"cyclophosphamide, mitomycin.c, dacarbazine, TH.302",0.239577516576788,0.159893905543242,FALSE
+"HCC95","Pearson.est","DNA inhibitor",-0.34654,-0.909,0.548,1100,0.675,"mechlorethamine, nithiamide, teroxirone, bendamustine, chlorambucil, valrubicin",0.261219441515631,0.170696227168975,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.57536,-1.53,0.0723,918,0.298,"disulfiram, fdcyd, SGI.1027, decitabine",1.14086170270547,0.525783735923745,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",0.39585,1.11,0.297,310,0.734,"famciclovir, cidofovir, foscarnet, menadione",0.527243550682788,0.134303940083929,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.38423,-1.01,0.417,1293,0.57,"artemisinin, mitomycin.c, azodicarbonamide, artesunate",0.379863945026242,0.244125144327509,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",0.3804,1.08,0.329,330,0.695,"amisulpride, UH.232...., remoxipride, raclopride, nemonapride, thioproperazine, isofloxythepin, domperidone",0.482804102050026,0.158015195409886,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.27946,-0.723,0.79,950,0.823,"estradiol, PPT, estradiol.cypionate, levonorgestrel",0.102372908709559,0.0846001647877302,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",0.68694,1.95,0.0114,11,0.146,"toremifene, fulvestrant",1.94309514866353,0.835647144215563,TRUE
+"HCC95","Pearson.est","FGFR inhibitor",-0.52185,-1.39,0.125,1178,0.386,"erdafitinib, dovitinib, lenvatinib, nintedanib",0.903089986991944,0.413412695328245,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",-0.45307,-1.18,0.25,1248,0.491,"TG.02, midostaurin, dovitinib, pacritinib, TG.101348, lestaurtinib",0.602059991327962,0.308918507877032,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.49086,-1.31,0.197,881,0.388,"prednisolone.acetate, halobetasol.propionate, difluprednate, halcinonide, prednisolone.hemisuccinate, ciclesonide, fluocinolone.acetonide, fluticasone.propionate, flumethasone, desonide, methylprednisolone, deflazacort, triamcinolone.acetonide, beclomethasone.dipropionate, triamcinolone, betamethasone, fluorometholone",0.705533773838407,0.411168274405793,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",0.31395,0.908,0.557,992,0.793,"latrepirdine, IEM1754, ACDPP, SIB.1757, tiletamine, JNJ.16259685, CPP, felbamate, diazooxonorleucine, LY456236, MTPG, kynurenic.acid, CGP.37849",0.254144804826271,0.100726812682396,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.27911,0.804,0.679,150,0.809,"kenpaullone, LY2090314, GSK.3.inhibitor.IX",0.168130225719498,0.0920514783877277,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.65709,-1.74,0.0237,1325,0.214,"PHA.848125, GSK1838705A, danusertib, lestaurtinib",1.6252516539899,0.669586226650809,TRUE
+"HCC95","Pearson.est","HCV inhibitor",0.31836,0.917,0.508,158,0.813,"narlaprevir, PSI.7976",0.294136287716081,0.0899094544059319,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.278,-0.724,0.774,1039,0.84,"chidamide, panobinostat, ACY.1215, scriptaid, pyroxamide, belinostat, RGFP966, NSC.3852, resminostat, vorinostat",0.111259039317107,0.0757207139381184,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",0.54948,1.61,0.072,271,0.218,"nizatidine, astemizole, famotidine, ICI.162846, tecastemizole, BF2.649, zolantidine, tiotidine, epinastine",1.14266750356873,0.661543506395395,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.76538,2.22,0,162,0.0702,"atorvastatin, pitavastatin, fluvastatin, lovastatin",Inf,1.15366288787019,TRUE
+"HCC95","Pearson.est","HSP inhibitor",-0.64617,-1.71,0.0267,986,0.185,"alvespimycin, NMS.E973, XL888, VER.49009, NVP.AUY922, ganetespib, SNX.5422, tanespimycin, SNX.2112, BIIB021, PU.H71",1.57348873863542,0.732828271596986,TRUE
+"HCC95","Pearson.est","JAK inhibitor",-0.50259,-1.34,0.155,966,0.38,"tozasertib, ruxolitinib, PRT062070, baricitinib, AT.9283, LY2784544, AZ960, TG.02, pacritinib, TG.101348, lestaurtinib",0.809668301829709,0.42021640338319,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.39138,-1.01,0.44,1094,0.57,"imatinib, masitinib, dasatinib, midostaurin, motesanib, lenvatinib",0.356547323513813,0.244125144327509,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.67816,1.91,0.0207,288,0.108,"idasanutlin, RITA, nutlin.3",1.68402965454308,0.96657624451305,TRUE
+"HCC95","Pearson.est","MEK inhibitor",0.68571,1.99,0.0154,333,0.17,"selumetinib, refametinib, TAK.733, MEK162, AZD8330, Ro.4987655, PD.184352, U.0126, cobimetinib, PD.98059, PD.318088, PD.0325901, trametinib, AS.703026, PD.198306",1.81247927916354,0.769551078621726,TRUE
+"HCC95","Pearson.est","MET inhibitor",-0.3439,-0.922,0.555,965,0.671,"NVP.BVU972, PF.04217903, LY2801653",0.255707016877324,0.173277479831008,FALSE
+"HCC95","Pearson.est","microtubule inhibitor",-0.57764,-1.52,0.081,1035,0.288,"vinblastine, podophyllotoxin, cabazitaxel, cytochalasin.b, triclabendazole, colchicine, vinflunine, D.64131",1.09151498112135,0.540607512240769,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.5199,-1.38,0.129,1020,0.359,"SB.2343, voxtalisib, temsirolimus, AZD2014, WAY.600, PF.04691502, NVP.BEZ235, MLN0128, sirolimus, AZD8055, OSI.027, GSK2126458, LY3023414, PF.05212384, WYE.125132, GDC.0980, everolimus",0.889410289700751,0.444905551421681,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",0.34137,0.989,0.448,107,0.743,"tyloxapol, parthenolide, BAY.11.7085",0.348721986001856,0.129011186239425,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",-0.31193,-0.814,0.672,1217,0.768,"salvinorin.a, spiradoline",0.172630726946175,0.114638779968488,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",-0.42806,-1.12,0.315,1108,0.53,"SB.239063, skepinone.l, talmapimod",0.501689446210399,0.275724130399211,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.59112,-1.55,0.0613,1006,0.322,"niraparib, PJ.34, endo.IWR.1, olaparib, talazoparib",1.21253952548158,0.492144128304169,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.38676,-1.01,0.426,1072,0.57,"ponatinib, imatinib, masitinib, crenolanib, dasatinib, motesanib, dovitinib, lenvatinib, linifanib, nintedanib",0.370590400897281,0.244125144327509,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.17656,0.498,0.982,395,0.983,"BVT.948, AS.1949490, menadione, alexidine",0.00788851221305034,0.00744648216786438,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.28878,0.835,0.639,367,0.895,"EMD.53998, enoximone, trequinsin, GSK256066",0.1944991418416,0.048176964684088,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.50704,-1.35,0.16,988,0.384,"idelalisib, SB.2343, voxtalisib, taselisib, GDC.0941, buparlisib, CUDC.907, PF.04691502, YM.201636, NVP.BEZ235, TG.100713, GSK2126458, LY3023414, PF.05212384, GDC.0980, CH5132799, PI3K.IN.2",0.795880017344075,0.415668775632469,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.77682,-2.03,0.00317,1235,0.0984,"HMN.214, NMS.1286937, GSK461364, GW.843682X, volasertib, BI.2536",2.49894073778225,1.00700490156866,TRUE
+"HCC95","Pearson.est","potassium channel blocker",-0.26737,-0.702,0.806,1032,0.832,"mepivacaine, ibutilide, ML133",0.0936649581949093,0.0798766737092761,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.37444,1.09,0.313,125,0.724,"clofibrate, GW.501516",0.504455662453552,0.140261433802853,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",0.1884,0.541,0.957,318,0.997,"nomegestrol.acetate, norgestrel, norethindrone.acetate",0.0190880622231565,0.00130484168834428,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",0.28188,0.817,0.665,39,0.854,"oprozomib",0.177178354696895,0.068542129310995,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",-0.43855,-1.15,0.29,1000,0.5,"tedizolid.phosphate, bruceantin, mercaptopurine, puromycin, anguidine, harringtonine, emetine, chloramphenicol.palmitate",0.537602002101044,0.301029995663981,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.44536,-1.18,0.283,1391,0.491,"PP.121, CP.724714",0.54821356447571,0.308918507877032,FALSE
+"HCC95","Pearson.est","RAF inhibitor",0.67295,1.93,0.0163,254,0.12,"dabrafenib, AZ.628, vemurafenib, CEP.32496, LGX818, SB.590885, PLX.4720",1.78781239559604,0.920818753952375,TRUE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.5291,-1.38,0.137,1199,0.359,"vandetanib, cabozantinib",0.863279432843593,0.444905551421681,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.28491,-0.747,0.749,1053,0.827,"bexarotene, CD.437, tamibarotene",0.125518182300534,0.0824944904474534,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.22867,0.645,0.898,1113,0.941,"pentostatin, gemcitabine, fludarabine, cladribine, hydroxyurea, triapine, clofarabine, cytarabine, fludarabine.phosphate, LY2334737",0.0467236633326956,0.0264103765727431,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",-0.31604,-0.827,0.665,1417,0.767,"pirenperone",0.177178354696895,0.115204636051019,FALSE
+"HCC95","Pearson.est","sodium channel blocker",0.41229,1.22,0.226,248,0.576,"A.803467, cibenzoline, benzethonium, ajmaline, quinidine",0.645891560852599,0.239577516576788,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.7274,-1.92,0.00626,1077,0.139,"PP.2, masitinib, KX2.391, bosutinib, dasatinib, saracatinib, TG.100572",2.20342566678957,0.856985199745905,TRUE
+"HCC95","Pearson.est","sterol demethylase inhibitor",-0.61546,-1.64,0.0416,1055,0.247,"sulconazole, terconazole, lanoconazole",1.38090666937326,0.607303046740334,TRUE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.43649,-1.15,0.288,821,0.5,"SB.525334, repsox, SB.431542, LY2109761, adaprev",0.540607512240769,0.301029995663981,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.40538,-1.07,0.371,876,0.575,"capecitabine, doxifluridine, carmofur, raltitrexed",0.430626090384954,0.24033215531037,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",-0.57304,-1.53,0.0773,1162,0.298,"topotecan, SN.38, irinotecan, exatecan.mesylate, etoposide, daunorubicin, licochalcone.a, genz.644282, camptothecin, fleroxacin, teniposide, mitoxantrone, TAS.103, amsacrine, valrubicin",1.11182050608168,0.525783735923745,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.68665,-1.79,0.0143,1035,0.19,"vinblastine, albendazole, vindesine, CYT.997, fosbretabulin, podophyllotoxin, KX2.391, dolastatin.10, mebendazole, verubulin, BNC105, indibulin, nocodazole, flubendazole, oxibendazole, plinabulin, parbendazole, fenbendazole, taltobulin, paclitaxel, ABT.751, epothilone.b, vinorelbine, docetaxel",1.84466396253494,0.721246399047171,TRUE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.38891,-1.03,0.42,1157,0.586,"tyrphostin.AG.99, vandetanib, tivantinib, cabozantinib, dasatinib, UNC2250, PP.121, CP.724714",0.3767507096021,0.232102383981909,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.46184,-1.21,0.228,1199,0.48,"vandetanib, cabozantinib, motesanib, BMS.690514, dovitinib, lenvatinib, foretinib, AEE788, TG.100572, XL.647, linifanib, nintedanib",0.642065152999546,0.318758762624413,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",0.27785,0.809,0.702,334,0.833,"ercalcitriol, maxacalcitol, alfacalcidol",0.153662887870195,0.0793549985932124,FALSE
+"H1650","Pearson.est","EGFR inhibitor",-0.3432,-0.982,0.444,1165,0.594,"AZD8931, canertinib, ARRY.334543, CP.724714, pelitinib, WZ8040, dovitinib, dacomitinib, AST.1306, PD.168393, BIBU.1361, poziotinib, osimertinib, FERb.033, BMS.690514, afatinib, icotinib, erlotinib, vandetanib",0.35261702988538,0.226213555018806,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",0.52231,1.31,0.178,347,1,"bosutinib, flumatinib, KW.2449, nilotinib, metatinib, imatinib",0.749579997691106,0,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.32694,0.817,0.697,432,0.973,"tremorine, nicotine",0.156767221901991,0.0118871597316481,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",0.30986,0.783,0.736,129,0.916,"dicycloverine",0.133122185662501,0.0381045263321496,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",0.42246,1.05,0.384,259,0.877,"sulmazole, PSB.1115",0.415668775632469,0.0570004066339595,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.25532,-0.712,0.812,1145,0.957,"A61603, buphenine, isoetharine, epinephrine, isoxsuprine, terbutaline",0.0904439707588247,0.0190880622231565,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.46659,1.18,0.286,497,0.921,"dronedarone, naftidrofuryl, dihydroergocristine, imiloxan, metoprolol, carvedilol, propranolol, oxprenolol, idazoxan, practolol",0.543633966870957,0.0357403698031511,FALSE
+"H1650","Pearson.est","AKT inhibitor",-0.21523,-0.619,0.932,308,0.953,"AT7867, palomid.529, ONC201, CCT128930, uprosertib, AZD5363, triciribine, A.674563, MK.2206, GSK2110183, GDC.0068",0.0305840876460186,0.0209070993616736,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.35893,0.904,0.564,333,0.992,"DMH1, AZD3463, crizotinib, brigatinib",0.248720896016658,0.00348832784582135,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",0.30195,0.762,0.78,491,0.907,"nilutamide, flutamide, enzalutamide",0.10790539730952,0.0423927129399047,FALSE
+"H1650","Pearson.est","antioxidant",0.4993,1.27,0.203,725,0.97,"chlorogenic.acid, trolox, taurine, rutin, benfotiamine, mesna",0.692503962086787,0.0132282657337552,FALSE
+"H1650","Pearson.est","AP inhibitor",-0.49486,-1.35,0.143,1146,0.433,"birinapant, LCL.161, GDC.0152",0.844663962534938,0.363512103646635,FALSE
+"H1650","Pearson.est","ATPase inhibitor",0.51671,1.3,0.156,596,0.951,"digoxin, digitoxin, rabeprazole, k.strophanthidin, omeprazole, ouabain, oligomycin.a, digitoxigenin, NMS.873",0.806875401645538,0.0218194830625861,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",-0.25176,-0.718,0.813,1160,0.992,"CCT137690, GSK1070916, AT.9283, PF.03814735, TAK.901, hesperadin, barasertib, MLN.8054, ZM.447439",0.0899094544059319,0.00348832784582135,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.54236,1.35,0.121,540,1,"valnemulin, josamycin, tedizolid, dirithromycin, azithromycin",0.91721462968355,0,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.21688,-0.617,0.915,311,0.919,"lomefloxacin, sparfloxacin, finafloxacin, novobiocin, norfloxacin, sarafloxacin, nadifloxacin, trovafloxacin",0.0385789059335517,0.0366844886138887,FALSE
+"H1650","Pearson.est","BCL inhibitor",-0.39515,-1.14,0.295,1125,0.579,"HA14.1, navitoclax, ABT.737, venetoclax",0.530177984021837,0.237321436272564,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.6161,1.53,0.0567,535,1,"bosutinib, flumatinib, nilotinib, metatinib, imatinib, GZD824, dasatinib",1.24641694110709,0,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",0.29469,0.73,0.802,189,0.933,"temazepam, indiplon, eprinomectin",0.0958256317158365,0.0301183562535,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.39851,0.993,0.463,499,0.948,"bromosporine, I.BET.762, I.BET151",0.334419008982047,0.0231916626619338,FALSE
+"H1650","Pearson.est","calcium channel blocker",0.36196,0.906,0.564,173,1,"carboxyamidotriazole, SR.33805",0.248720896016658,0,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",0.47565,1.18,0.25,196,0.921,"navarixin, SB.225002",0.602059991327962,0.0357403698031511,FALSE
+"H1650","Pearson.est","CDK inhibitor",0.48975,1.23,0.219,455,0.882,"BMS.265246, BMS.387032, P276.00, dinaciclib, PHA.793887, JNJ.7706621, aminopurvalanol.a, kenpaullone, indirubin, TG.02, AT.7519, PHA.848125",0.659555885159882,0.0545314148681803,FALSE
+"H1650","Pearson.est","CHK inhibitor",-0.84939,-2.4,0,1252,0.00698,"SCH.900776, PF.477736, CHIR.124, LY2606368, AZD7762, LY2603618",Inf,2.15614457737684,TRUE
+"H1650","Pearson.est","cyclooxygenase inhibitor",0.34258,0.857,0.644,362,0.975,"tryptanthrin, FR.122047, sulfasalazine, piroxicam, indoprofen, suxibuzone, tepoxalin, ketoprofen",0.191114132640188,0.0109953843014632,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",0.42646,1.07,0.404,4,0.942,"itraconazole",0.393618634889395,0.0259490972071227,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.37778,0.937,0.535,232,1,"temozolomide, carboplatin, satraplatin, streptozotocin",0.271646217978772,0,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.26721,0.667,0.86,430,0.991,"carboplatin, sangivamycin, primaquine, pibenzimol, tirapazamine, carmustine, busulfan",0.0655015487564323,0.00392634551472468,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",-0.62533,-1.81,0.0351,1211,0.175,"azacitidine, decitabine, fdcyd",1.45469288353418,0.756961951313706,TRUE
+"H1650","Pearson.est","DNA polymerase inhibitor",-0.49698,-1.42,0.104,1395,0.436,"adefovir.dipivoxil, trifluridine, cephalomannine",0.98296666070122,0.360513510731414,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",-0.52685,-1.56,0.0731,1342,0.316,"estramustine.phosphate, floxuridine, capecitabine, artesunate",1.13608262304214,0.500312917381596,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",-0.42326,-1.2,0.246,1378,0.519,"piperacetazine, sertindole, clebopride, thioproperazine",0.609064892896621,0.284832642151542,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",-0.34519,-0.991,0.454,495,0.682,"equol, estradiol, estrone, erteberel, estradiol.cypionate, PPT, ethinyl.estradiol, levonorgestrel",0.342944147142896,0.166215625343521,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",0.57476,1.44,0.0927,429,1,"danazol, raloxifene, tamoxifen, clomifene",1.0329202658555,0,FALSE
+"H1650","Pearson.est","FGFR inhibitor",0.44233,1.11,0.332,503,1,"AZD4547, erdafitinib, regorafenib, lucitanib, PD.173074, nintedanib",0.478861916295964,0,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.45241,1.1,0.349,514,1,"ENMD.2076, GTP.14564, TG.101348, tyrphostin.AG.1296, KW.2449, tandutinib, TG.02, quizartinib, sorafenib",0.45717457304082,0,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",-0.36822,-1.03,0.389,1237,0.692,"fluticasone.propionate, desonide, dexamethasone.acetate, prednisolone.hemisuccinate, triamcinolone.acetonide, prednisolone.acetate, fludroxycortide",0.410050398674292,0.159893905543242,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",0.39998,1.01,0.454,636,0.942,"LY456236, tiletamine, diazooxonorleucine, CGP.37849, IEM1754, MTPG, CPP, ACDPP",0.342944147142896,0.0259490972071227,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.3526,0.878,0.615,365,0.99,"GSK.3.inhibitor.IX, tideglusib, kenpaullone, indirubin",0.211124884224583,0.00436480540245009,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.48537,1.23,0.227,455,0.882,"GSK1904529A, AZD3463, PHA.848125",0.643974142806877,0.0545314148681803,FALSE
+"H1650","Pearson.est","HCV inhibitor",0.59355,1.48,0.0689,581,1,"PSI.7976, narlaprevir, daclatasvir, mericitabine, embelin",1.16178077809237,0,FALSE
+"H1650","Pearson.est","HDAC inhibitor",0.26313,0.655,0.869,465,0.965,"M.344, AR.42, mocetinostat, givinostat, pyroxamide, entinostat, R306465, PCI.24781, RG2833, tacedinaline, SB.939",0.0609802235513335,0.0154726866562074,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",0.20931,0.524,0.979,332,1,"zolantidine, chloropyramine, lafutidine, tecastemizole",0.00921730819686218,0,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.34935,-0.983,0.434,1164,0.623,"mevastatin, pitavastatin, simvastatin",0.362510270487489,0.20551195334083,FALSE
+"H1650","Pearson.est","HSP inhibitor",-0.42066,-1.2,0.218,1098,0.519,"VER.49009, ganetespib, SNX.2112, BIIB021, tanespimycin, alvespimycin",0.661543506395395,0.284832642151542,FALSE
+"H1650","Pearson.est","JAK inhibitor",0.41793,1.05,0.387,387,0.877,"filgotinib, CEP.33779, AZD1480, TG.101348, TG.101209, AZ960, TG.02, atiprimod",0.412289034981089,0.0570004066339595,FALSE
+"H1650","Pearson.est","KIT inhibitor",0.30913,0.776,0.734,687,0.907,"cediranib, tandutinib, regorafenib, pazopanib, imatinib, masitinib, sorafenib, dasatinib, lenvatinib, KI.8751, telatinib",0.134303940083929,0.0423927129399047,FALSE
+"H1650","Pearson.est","MDM inhibitor",-0.68225,-1.9,0.0146,1313,0.152,"RITA, serdemetan",1.83564714421556,0.818156412055227,TRUE
+"H1650","Pearson.est","MEK inhibitor",-0.29227,-0.84,0.619,1106,0.82,"selumetinib, cobimetinib, Ro.4987655, trametinib, AZD8330, TAK.733, PD.318088, BIX.02188",0.208309350979882,0.0861861476162833,FALSE
+"H1650","Pearson.est","MET inhibitor",-0.24164,-0.701,0.843,347,0.934,"PHA.665752, AMG458, PF.04217903, NVP.BVU972, LY2801653, INC.280",0.0741724253752577,0.0296531237699066,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.35292,0.886,0.602,389,1,"D.64131, secnidazole, cabazitaxel",0.220403508742175,0,FALSE
+"H1650","Pearson.est","mTOR inhibitor",0.45655,1.15,0.301,587,0.96,"ku.0063794, PP242, torin.1, PKI.179, WYE.354, AZD8055, AZD2014, GSK2126458, OSI.027, deforolimus, palomid.529, MLN0128, PF.04691502, GDC.0980, XL388, SB.2343, voxtalisib",0.521433504406157,0.0177287669604316,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",0.33573,0.85,0.661,323,0.962,"bindarit, EVP4593, Ro.106.9920, tyloxapol",0.17979854051436,0.0168249279621871,FALSE
+"H1650","Pearson.est","opioid receptor agonist",0.56327,1.4,0.123,183,1,"trimebutine, cebranopadol",0.910094888560602,0,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.36882,0.92,0.571,267,1,"skepinone.l, talmapimod",0.243363891754152,0,FALSE
+"H1650","Pearson.est","PARP inhibitor",0.49924,1.25,0.212,527,0.956,"niraparib, olaparib, PJ.34, endo.IWR.1, AG.14361",0.673664139071249,0.0195421077238999,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.31615,0.797,0.724,535,0.96,"trapidil, crenolanib, tandutinib, regorafenib, pazopanib, imatinib, masitinib, CP.673451, nintedanib, sorafenib, dasatinib",0.140261433802853,0.0177287669604316,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",0.31217,0.793,0.738,180,0.944,"menadione, AS.1949490, BVT.948",0.131943638176958,0.025028005701931,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",-0.35764,-1.01,0.392,1350,0.685,"trequinsin, papaverine",0.406713932979543,0.164309428507574,FALSE
+"H1650","Pearson.est","PI3K inhibitor",0.42417,1.06,0.391,785,0.926,"alpelisib, ZSTK.474, PKI.179, BGT226, GSK2126458, PI.828, pilaralisib, buparlisib, PF.04691502, GDC.0980, PI3K.IN.2, SB.2343, voxtalisib, taselisib, TG.100713, NVP.BEZ235, LY303511, CH5132799, GDC.0941, YM.201636, CUDC.907, PIK.75",0.407823242604133,0.0333890133180656,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.32229,0.802,0.697,680,0.975,"NMS.1286937, HMN.214, rigosertib",0.156767221901991,0.0109953843014632,FALSE
+"H1650","Pearson.est","potassium channel blocker",-0.40111,-1.13,0.286,576,0.554,"dofetilide, mepivacaine, meglitinide, ML133, oleoylethanolamide, ibutilide",0.543633966870957,0.25649023527157,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",0.25157,0.638,0.905,1081,0.963,"GW.501516, clofibrate, pterostilbene, ciprofibrate, oleoylethanolamide, S26948, fenofibrate",0.0433514207947967,0.0163737128754655,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",0.36928,0.937,0.532,630,1,"danazol, melengestrol.acetate, dienogest, norethindrone, tanaproget",0.274088367704952,0,FALSE
+"H1650","Pearson.est","proteasome inhibitor",-0.62273,-1.77,0.0253,1120,0.167,"oprozomib, bortezomib, ixazomib.citrate, ixazomib, delanzomib, ONX.0914",1.59687947882418,0.777283528852417,TRUE
+"H1650","Pearson.est","protein synthesis inhibitor",0.43039,1.08,0.367,361,0.96,"cycloheximide, mercaptopurine, bruceantin, clofoctol, chloramphenicol.palmitate, brefeldin.a, florfenicol, homoharringtonine",0.435333935747911,0.0177287669604316,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.44253,1.09,0.368,367,0.98,"mubritinib, BMS.599626, rheochrysidin, tyrphostin.A9",0.434152181326482,0.00877392430750515,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.52797,1.32,0.149,664,1,"CEP.32496, TAK.632, SB.590885, regorafenib, PLX.4720, sorafenib, RAF265, AZ.628, vemurafenib",0.826813731587726,0,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.31061,0.783,0.745,514,0.916,"apatinib, regorafenib, sorafenib",0.127843727251707,0.0381045263321496,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",-0.82902,-2.41,0,1357,0.0105,"CD.437, adapalene, bexarotene, AM.580",Inf,1.97881070093006,TRUE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.25436,0.633,0.885,437,0.95,"fludarabine, hydroxyurea, cladribine, LY2334737",0.0530567293021746,0.0222763947111523,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",0.26986,0.665,0.854,569,0.973,"SB.200646, lerisetron, lurasidone, RS.16566, SB.216641, SB.228357",0.068542129310995,0.0118871597316481,FALSE
+"H1650","Pearson.est","sodium channel blocker",-0.22592,-0.644,0.896,1256,0.965,"ajmaline, brivaracetam, A.803467",0.0476919903378748,0.0154726866562074,FALSE
+"H1650","Pearson.est","src inhibitor",0.34117,0.859,0.622,597,0.998,"bosutinib, PP.1, masitinib, saracatinib, dasatinib, KX2.391",0.206209615309181,0.000869458712628891,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",0.58547,1.45,0.0801,294,1,"lanoconazole, chlormidazole, posaconazole",1.09636748391576,0,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.51184,-1.41,0.122,735,0.395,"repsox, SB.431542, D.4476, adaprev, SB.525334, LY2109761",0.913640169325252,0.40340290437354,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",-0.44373,-1.27,0.184,1425,0.505,"trifluridine, capecitabine",0.735182176990464,0.296708621881339,FALSE
+"H1650","Pearson.est","topoisomerase inhibitor",-0.36338,-0.987,0.441,1318,0.65,"beta.lapachone, topotecan, irinotecan, rubitecan, camptothecin, exatecan.mesylate",0.355561410532161,0.187086643357144,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.20292,0.511,0.966,658,0.993,"mebendazole, epothilone.d, oxibendazole, fenbendazole, CYT.997, combretastatin.A.4, ABT.751, KX2.391, vincristine, paclitaxel, plinabulin",0.0150228735845067,0.00305075150461883,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.33369,0.842,0.659,367,0.952,"GTP.14564, mubritinib, BMS.599626, rheochrysidin, apatinib, regorafenib, aminopurvalanol.a, tivantinib, tyrphostin.A9",0.18111458540599,0.0213630516155257,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.18765,0.469,0.997,514,0.988,"cediranib, ENMD.2076, golvatinib, regorafenib, pazopanib, MGCD.265, SAR131675, lucitanib, PD.173074, tivozanib, nintedanib, sorafenib",0.00130484168834428,0.00524305541237188,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",0.56069,1.42,0.106,306,1,"tacalcitol, alfacalcidol, ercalcitriol, maxacalcitol",0.97469413473523,0,FALSE
+"H1975","Pearson.est","EGFR inhibitor",-0.65752,-1.96,0.0123,1061,0.179,"PD.153035, icotinib, vandetanib, CNX.2006, rociletinib, CP.724714, neratinib, afatinib, tucatinib, BIBX.1382, erlotinib, osimertinib, WZ.4002, lapatinib, dacomitinib, XL.647, BMS.690514, PD.168393, GW.583340, canertinib, AZD8931, WZ8040, poziotinib, WZ.3146, pelitinib, BIBU.1361",1.9100948885606,0.747146969020107,TRUE
+"H1975","Pearson.est","Abl kinase inhibitor",-0.33708,-1,0.408,1302,0.649,"GZD824, dasatinib, bosutinib",0.38933983691012,0.187755303199631,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",0.43255,1.16,0.293,456,0.764,"pilocarpine, tremorine, nefiracetam, nicotine",0.533132379645891,0.11690664142431,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",0.63138,1.69,0.0251,316,1,"dicycloverine, iododexetimide, methscopolamine",1.60032627851896,0,FALSE
+"H1975","Pearson.est","adenosine receptor antagonist",0.48316,1.3,0.182,459,0.755,"SCH.58261, theophylline, PSB.1115, istradefylline, sulmazole",0.739928612014925,0.122053048370812,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",0.24451,0.667,0.872,526,0.996,"isoetharine, clenbuterol, buphenine, terbutaline, epinephrine, A61603",0.0594835150674328,0.00174066157630127,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.27373,0.748,0.743,344,0.93,"carvedilol, idazoxan, pindolol, atipamezole, vincamine, oxprenolol",0.129011186239425,0.0315170514460649,FALSE
+"H1975","Pearson.est","AKT inhibitor",-0.38873,-1.17,0.256,1158,0.517,"CCT128930, triciribine, GDC.0068, AT7867, MK.2206",0.59176003468815,0.286509456906058,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.51472,-1.54,0.0781,1221,0.241,"SB.505124, lorlatinib, AP26113, AZD3463, CEP.37440",1.1073489661227,0.617982957425132,FALSE
+"H1975","Pearson.est","antioxidant",0.41654,1.13,0.326,659,0.753,"trolox, chlorogenic.acid, benfotiamine",0.486782399932061,0.123205023799299,FALSE
+"H1975","Pearson.est","AP inhibitor",-0.60799,-1.81,0.0265,1156,0.168,"GDC.0152, tanshinone.i, idronoxil",1.57675412606319,0.774690718274137,TRUE
+"H1975","Pearson.est","ATPase inhibitor",0.55161,1.48,0.0875,185,0.706,"ouabain, digitoxin, evodiamine, thonzonium, digitoxigenin",1.05799194697769,0.151195298948196,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",0.37194,1,0.434,178,0.724,"TAK.901, MK.5108, alisertib, tozasertib, barasertib, ZM.447439, AMG900",0.362510270487489,0.140261433802853,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.40004,1.08,0.36,212,0.726,"azalomycin.b, valnemulin",0.443697499232713,0.139063379299906,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",0.44353,1.2,0.254,238,0.713,"trovafloxacin, nadifloxacin, sarafloxacin, norfloxacin",0.595166283380062,0.146910470148134,FALSE
+"H1975","Pearson.est","BCL inhibitor",-0.44562,-1.29,0.166,1228,0.415,"navitoclax, ABT.737, venetoclax",0.779891911959945,0.381951903287907,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.37221,-1.11,0.331,1302,0.573,"GZD824, dasatinib, bosutinib",0.480172006224281,0.24184537803261,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",-0.24105,-0.743,0.758,1260,0.912,"bentazepam, CGS.20625",0.120330794367946,0.0400051616715838,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",0.33045,0.889,0.578,249,0.808,"I.BET151",0.238072161579471,0.0925886392254138,FALSE
+"H1975","Pearson.est","calcium channel blocker",-0.32082,-0.952,0.488,436,0.696,"SKF.96365, tetrandrine, mibefradil, SR.33805, efonidipine.monoethanolate, carboxyamidotriazole, penfluridol",0.311580177997289,0.157390760389438,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",0.56105,1.48,0.0866,397,0.706,"ZK811752, MK.0812, RS.504393, SB.225002",1.06248210798265,0.151195298948196,FALSE
+"H1975","Pearson.est","CDK inhibitor",0.17686,0.483,0.982,413,1,"dinaciclib, PHA.793887, palbociclib, ribociclib, NU6027, abemaciclib, AT.7519",0.00788851221305034,0,FALSE
+"H1975","Pearson.est","CHK inhibitor",0.28109,0.752,0.768,984,0.947,"LY2606368, SB.218078, PF.477736, AZD7762, SCH.900776, CHIR.124, LY2603618",0.114638779968488,0.0236500209967266,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.18748,-0.567,0.957,1171,0.989,"phenazone, tryptanthrin, phenylbutazone, ramifenazone",0.0190880622231565,0.0048037084028206,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",0.406,1.09,0.354,462,0.804,"PF.4981517, cobicistat",0.450996737974212,0.0947439512515487,FALSE
+"H1975","Pearson.est","DNA alkylating agent",0.14156,0.389,0.992,523,0.998,"estramustine, mitomycin.c, melphalan, cisplatin, satraplatin",0.00348832784582135,0.000869458712628891,FALSE
+"H1975","Pearson.est","DNA inhibitor",-0.21428,-0.634,0.88,1163,0.971,"nithiamide, pibenzimol, chlorambucil, sangivamycin",0.0555173278498314,0.0127807700919951,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",0.36583,0.995,0.455,91,0.711,"menadione, cephalomannine",0.341988603342888,0.148130399270234,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",0.35272,0.939,0.522,507,0.79,"estramustine.phosphate, cyclocytidine, mitomycin.c, anisomycin, CB.10.277, capecitabine, artesunate, cisplatin",0.282329496997738,0.102372908709559,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",0.24085,0.653,0.879,471,0.99,"paliperidone, nemonapride, UH.232...., domperidone, amisulpride, piperacetazine",0.0560111249262281,0.00436480540245009,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.5283,-1.57,0.0559,1343,0.25,"equol, ethinyl.estradiol",1.25258819211358,0.602059991327962,FALSE
+"H1975","Pearson.est","FGFR inhibitor",0.47288,1.27,0.203,375,0.629,"nintedanib, MK.2461, regorafenib, erdafitinib",0.692503962086787,0.201349354554731,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",0.20237,0.557,0.969,1093,1,"tozasertib, tandutinib, tyrphostin.AG.1296, TG.02, gilteritinib, sunitinib, ENMD.2076, ponatinib, lestaurtinib, sorafenib, dovitinib, quizartinib, GTP.14564, midostaurin, pacritinib, TG.101348, KW.2449",0.0136762229492347,0,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",-0.53122,-1.57,0.0833,1088,0.25,"piretanide, ciclesonide, difluprednate, fluticasone.propionate, prednisolone.acetate, fluorometholone, clobetasol.propionate, dexamethasone.acetate, betamethasone, flumethasone.pivalate, triamcinolone.acetonide",1.07935499859321,0.602059991327962,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",0.39527,1.04,0.417,509,0.779,"LY456236, MTPG, ACDPP, felbamate, IEM1754, diazooxonorleucine",0.379863945026242,0.108462542327436,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.28155,-0.846,0.634,1251,0.812,"LY2090314, TWS.119",0.197910742118267,0.0904439707588247,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",-0.70055,-2.07,0.00286,1195,0.205,"GSK1904529A, AZD3463, PHA.848125",2.54363396687096,0.688246138944246,TRUE
+"H1975","Pearson.est","HDAC inhibitor",0.40054,1.08,0.352,551,0.726,"RGFP966, RG2833, M.344, belinostat, givinostat, trichostatin.a, panobinostat, R306465, ACY.1215, nexturastat.a, SB.939, dacinostat, pyroxamide, resminostat, scriptaid, vorinostat",0.453457336521869,0.139063379299906,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",0.50531,1.35,0.148,434,0.749,"astemizole, lafutidine, ICI.162846, epinastine, cimetidine, BF2.649, famotidine, nizatidine, tecastemizole",0.829738284605043,0.125518182300534,FALSE
+"H1975","Pearson.est","HSP inhibitor",-0.26534,-0.764,0.73,359,0.92,"BIIB021, tanespimycin, NVP.AUY922, KW.2478, alvespimycin, guanidine, SNX.2112, XL888, ganetespib, SNX.5422, PU.H71, VER.49009, NMS.E973",0.136677139879544,0.0362121726544447,FALSE
+"H1975","Pearson.est","JAK inhibitor",0.37757,1.01,0.438,599,0.754,"tozasertib, PRT062070, AZD1480, WHI.P154, AT.9283, TG.02, TG.101209, AZ960, baricitinib",0.3585258894959,0.122628654130226,FALSE
+"H1975","Pearson.est","KIT inhibitor",0.34812,0.934,0.543,438,0.775,"masitinib, imatinib, tandutinib, regorafenib, telatinib, cediranib",0.265200170411153,0.11069829749369,FALSE
+"H1975","Pearson.est","MDM inhibitor",0.43043,1.15,0.317,9,0.748,"serdemetan",0.498940737782249,0.126098402135539,FALSE
+"H1975","Pearson.est","MEK inhibitor",-0.47669,-1.44,0.0984,1023,0.278,"MEK1.2.inhibitor, nobiletin, refametinib, AS.703026, cobimetinib, trametinib, TAK.733, PD.0325901, Ro.4987655, PD.318088, AZD8330",1.00700490156866,0.555955204081924,FALSE
+"H1975","Pearson.est","MET inhibitor",0.55825,1.47,0.0913,506,0.634,"INC.280, NVP.BVU972, AMG458, LY2801653, PHA.665752",1.0395292224657,0.197910742118267,FALSE
+"H1975","Pearson.est","microtubule inhibitor",0.62755,1.68,0.0375,156,0.467,"vinflunine, estramustine.phosphate, vinblastine, cabazitaxel, triclabendazole, D.64131",1.42596873227228,0.330683119433888,FALSE
+"H1975","Pearson.est","mTOR inhibitor",-0.34562,-1.04,0.36,1085,0.617,"PKI.179, PP242, PI.103, everolimus, torin.1, OSI.027, torin.2, WYE.354, SB.2343, WAY.600, ku.0063794, XL388",0.443697499232713,0.209714835966758,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",-0.27897,-0.847,0.622,378,0.853,"betulinic.acid, IKK.2.inhibitor.V, BAY.11.7085, bindarit, Ro.106.9920, bortezomib, curcumin, EVP4593, BAY.11.7082, parthenolide...., parthenolide",0.206209615309181,0.069050968832477,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",-0.23915,-0.717,0.814,325,0.909,"talmapimod, TAK.715, CMPD.1, skepinone.l, SB.239063, VX.702, SB.242235",0.0893755951107988,0.0414361167780325,FALSE
+"H1975","Pearson.est","PARP inhibitor",0.48618,1.29,0.214,356,0.67,"talazoparib, niraparib, endo.IWR.1, olaparib",0.669586226650809,0.173925197299174,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.40156,1.08,0.377,395,0.726,"linifanib, nintedanib, masitinib, imatinib, tandutinib, crenolanib, CP.673451, regorafenib, telatinib",0.423658649794207,0.139063379299906,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",0.27934,0.755,0.761,321,0.967,"menadione, mycophenolate.mofetil, AS.1949490",0.118615343229427,0.0145735259169983,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",0.19034,0.505,0.975,428,1,"EMD.53998, YM.976, papaverine",0.0109953843014632,0,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.19485,0.535,0.976,394,1,"PF.05212384, PF.04691502, GDC.0941, AZD6482, GDC.0980, NVP.BEZ235, CH5132799, PI.828, voxtalisib",0.0105501823333082,0,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.63793,1.68,0.037,481,0.467,"BI.2536, volasertib, rigosertib, GSK461364, HMN.214, GW.843682X",1.431798275933,0.330683119433888,FALSE
+"H1975","Pearson.est","potassium channel blocker",0.3012,0.805,0.699,233,0.91,"meglitinide, oleoylethanolamide",0.155522824254319,0.0409586076789064,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",0.49317,1.29,0.175,233,0.67,"GW.501516, oleoylethanolamide",0.756961951313706,0.173925197299174,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",0.54412,1.46,0.0937,311,0.584,"norethindrone.acetate, melengestrol.acetate, dienogest, nomegestrol.acetate, danazol",1.02826040911222,0.233587152887601,FALSE
+"H1975","Pearson.est","proteasome inhibitor",0.5076,1.36,0.124,467,0.797,"ONX.0914, carfilzomib, MG.132, oprozomib",0.906578314837765,0.0985416786038876,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.4684,1.25,0.218,307,0.634,"chloramphenicol.palmitate, azomycin..2.nitroimidazole., homoharringtonine, puromycin, bruceantin, anguidine, harringtonine, emetine, cycloheximide",0.661543506395395,0.197910742118267,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",-0.57903,-1.69,0.0439,1039,0.222,"rheochrysidin, mubritinib, CP.724714, AV.412",1.35753547975788,0.653647025549361,TRUE
+"H1975","Pearson.est","RAF inhibitor",-0.35174,-1.04,0.368,1094,0.617,"CEP.32496, TAK.632, LGX818, RAF265, PLX.4720",0.434152181326482,0.209714835966758,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.37577,1.03,0.418,366,0.769,"apatinib, regorafenib",0.378823718224965,0.114073660198569,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.37817,1.01,0.435,150,0.754,"LE.135, fenretinide",0.361510743045363,0.122628654130226,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.48764,-1.47,0.0948,1110,0.275,"hydroxyurea, pentostatin, fludarabine.phosphate, cladribine, cytarabine",1.02319166266193,0.560667306169737,FALSE
+"H1975","Pearson.est","serotonin receptor antagonist",0.36994,1,0.448,695,0.724,"paliperidone, SB.228357, pirenperone, tropisetron, RS.16566, lurasidone, lerisetron",0.348721986001856,0.140261433802853,FALSE
+"H1975","Pearson.est","sodium channel blocker",0.3062,0.825,0.652,41,0.897,"benzocaine, butamben",0.18575240426808,0.0472075569559079,FALSE
+"H1975","Pearson.est","src inhibitor",-0.40301,-1.2,0.243,1297,0.512,"saracatinib, dasatinib, bosutinib",0.614393726401688,0.290730039024169,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",-0.63509,-1.83,0.0123,1180,0.206,"posaconazole, lanoconazole, terconazole",1.9100948885606,0.686132779630847,TRUE
+"H1975","Pearson.est","TGF beta receptor inhibitor",-0.18685,-0.539,0.967,1103,0.967,"LY2109761, repsox",0.0145735259169983,0.0145735259169983,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.48492,1.3,0.191,457,0.755,"ftorafur, raltitrexed, doxifluridine, capecitabine",0.718966632752272,0.122053048370812,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",0.47352,1.28,0.2,439,0.649,"nemorubicin, daunorubicin, exatecan.mesylate, amsacrine, etoposide, mitoxantrone, dexrazoxane, rubitecan, idarubicin, irinotecan, doxorubicin, valrubicin, topotecan, fleroxacin",0.698970004336019,0.187755303199631,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",0.61565,1.65,0.0261,417,0.425,"flubendazole, combretastatin.A.4, taltobulin, vinblastine, paclitaxel, vindesine, verubulin, fosbretabulin, parbendazole, docetaxel, vincristine, albendazole, dolastatin.10, epothilone.b, mebendazole, BNC105, nocodazole, fenbendazole, plinabulin, oxibendazole, ABT.751, podophyllotoxin, KX2.391",1.58335949266172,0.371611069949688,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",0.21118,0.56,0.945,261,1,"tivantinib, UNC2250, AMG.208, hypericin, apatinib",0.0245681914907371,0,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",0.26859,0.706,0.81,438,0.968,"SAR131675, golvatinib, linifanib, nintedanib, foretinib, TG.100572, MK.2461, regorafenib, telatinib, AEE788, tivozanib, cediranib",0.0915149811213502,0.0141246426916063,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.33279,0.899,0.571,427,0.815,"alfacalcidol, tacalcitol, calcitriol",0.243363891754152,0.0888423912600234,FALSE
+"H2009","Pearson.est","EGFR inhibitor",-0.48523,-1.3,0.181,1012,0.604,"afatinib, dacomitinib, BIBU.1361, poziotinib, AZD8931, PD.153035, neratinib, PD.168393, lapatinib, erlotinib, tyrphostin.AG.494, canertinib, pelitinib, ARRY.334543, OSI.420, osimertinib, tyrphostin.AG.1478, TAK.285, WZ.4002, gefitinib",0.742321425130815,0.218963061378868,FALSE
+"H2009","Pearson.est","Abl kinase inhibitor",0.61654,1.83,0.0193,297,0.0998,"flumatinib, nilotinib, bafetinib, ponatinib, tozasertib, dasatinib, GZD824",1.71444269099223,1.00086945871263,TRUE
+"H2009","Pearson.est","acetylcholine receptor agonist",-0.45869,-1.22,0.247,1045,0.686,"nefiracetam, tremorine, nicotine, pilocarpine",0.607303046740334,0.163675884293248,FALSE
+"H2009","Pearson.est","acetylcholine receptor antagonist",-0.42446,-1.12,0.346,876,0.605,"hyoscyamine, darifenacin, methscopolamine, dicycloverine",0.460923901207223,0.218244625347531,FALSE
+"H2009","Pearson.est","adenosine receptor antagonist",-0.56455,-1.53,0.0774,794,0.59,"PSB.1115, sulmazole, SCH.58261, MRS.1220, CGS.15943",1.11125903931711,0.229147988357856,FALSE
+"H2009","Pearson.est","adrenergic receptor agonist",-0.32352,-0.866,0.59,826,0.709,"A61603, oxymetazoline, methyldopa, lidamidine, isoetharine, terbutaline, midodrine, metaraminol",0.229147988357856,0.149353764816933,FALSE
+"H2009","Pearson.est","adrenergic receptor antagonist",-0.41966,-1.12,0.316,844,0.605,"vincamine, propranolol, pindolol, metoprolol, idazoxan, levobunolol, carvedilol, oxprenolol, prazosin, atenolol....",0.500312917381596,0.218244625347531,FALSE
+"H2009","Pearson.est","AKT inhibitor",-0.36319,-0.972,0.481,913,0.688,"GDC.0068, GSK2110183, AZD5363, A.674563, uprosertib, CCT128930",0.317854923626168,0.162411561764489,FALSE
+"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.27043,0.819,0.644,993,0.828,"brigatinib, DMH1, CEP.37440, GW.788388, alectinib, crizotinib, SB.505124, lorlatinib, AZD3463, AP26113, NVP.TAE684",0.191114132640188,0.0819696632151199,FALSE
+"H2009","Pearson.est","antioxidant",-0.55937,-1.49,0.0804,783,0.398,"trolox, rutin, benfotiamine, taurine, chlorogenic.acid",1.09474395125155,0.400116927926312,FALSE
+"H2009","Pearson.est","AP inhibitor",0.47646,1.4,0.117,143,0.253,"GDC.0152, birinapant, LCL.161",0.931814138253838,0.596879478824182,FALSE
+"H2009","Pearson.est","ATPase inhibitor",0.34925,1.03,0.369,121,0.598,"ouabain, digoxin",0.43297363384094,0.223298816011589,FALSE
+"H2009","Pearson.est","Aurora kinase inhibitor",0.57384,1.68,0.0344,257,0.159,"barasertib.HQPA, hesperadin, danusertib, PF.03814735, AMG900, AT.9283, barasertib, ENMD.2076, alisertib, SNS.314, tozasertib, CCT137690",1.46344155742847,0.798602875679548,TRUE
+"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.32978,-0.878,0.601,1019,0.71,"josamycin, azithromycin, dirithromycin",0.22112552799726,0.148741651280925,FALSE
+"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.33905,-0.922,0.535,918,0.703,"trovafloxacin, sparfloxacin",0.271646217978772,0.153044674980176,FALSE
+"H2009","Pearson.est","BCL inhibitor",0.34841,1.03,0.378,887,0.598,"gossypol, navitoclax, obatoclax, ABT.737, HA14.1, TW.37, oridonin, venetoclax",0.422508200162775,0.223298816011589,FALSE
+"H2009","Pearson.est","Bcr.Abl kinase inhibitor",0.71573,2.09,0.0148,297,0.0988,"flumatinib, nilotinib, bafetinib, ponatinib, tozasertib, dasatinib, GZD824",1.82973828460504,1.00524305541237,TRUE
+"H2009","Pearson.est","benzodiazepine receptor agonist",-0.42834,-1.15,0.3,1000,0.669,"piperazine, bentazepam, nefiracetam, gamma.aminobutyric.acid, indiplon, CL.218872, zaleplon",0.522878745280338,0.174573882232177,FALSE
+"H2009","Pearson.est","bromodomain inhibitor",-0.55892,-1.5,0.0748,1061,0.486,"JQ1...., I.BET151, I.BET.762",1.12609840213554,0.313363730737707,FALSE
+"H2009","Pearson.est","calcium channel blocker",0.24006,0.709,0.815,136,0.948,"SKF.96365, tetrandrine",0.0888423912600234,0.0231916626619338,FALSE
+"H2009","Pearson.est","CC chemokine receptor antagonist",-0.41115,-1.12,0.321,846,0.605,"ZK811752, SB.225002, MK.0812, PF.04136309, navarixin",0.493494967595128,0.218244625347531,FALSE
+"H2009","Pearson.est","CDK inhibitor",-0.45477,-1.21,0.245,899,0.663,"alvocidib, PHA.793887, AT.7519, BMS.387032, abemaciclib, JNJ.7706621, dinaciclib, indirubin, kenpaullone, BMS.265246, NU6027, P276.00, R547, arcyriaflavin.a",0.610833915635468,0.178486471595227,FALSE
+"H2009","Pearson.est","CHK inhibitor",-0.29759,-0.799,0.712,1317,0.789,"SB.218078",0.147520006363144,0.10292299679058,FALSE
+"H2009","Pearson.est","cyclooxygenase inhibitor",-0.36274,-0.99,0.451,1101,0.732,"ramifenazone, suxibuzone, pterostilbene, ketoprofen, FK.3311, aspirin, tryptanthrin",0.345823458122039,0.135488918941608,FALSE
+"H2009","Pearson.est","cytochrome P450 inhibitor",0.33599,1.02,0.401,20,0.585,"metyrapone",0.396855627379818,0.23284413391782,FALSE
+"H2009","Pearson.est","DNA alkylating agent",-0.4458,-1.2,0.251,1034,0.645,"carboplatin, cisplatin, melphalan, satraplatin, ifosfamide, cyclophosphamide",0.600326278518962,0.190440285364732,FALSE
+"H2009","Pearson.est","DNA inhibitor",0.30131,0.894,0.534,77,0.748,"valrubicin, nimorazole, primaquine",0.272458742971444,0.126098402135539,FALSE
+"H2009","Pearson.est","DNA methyltransferase inhibitor",0.41151,1.23,0.212,366,0.41,"SGI.1027, decitabine, azacitidine",0.673664139071249,0.387216143280265,FALSE
+"H2009","Pearson.est","DNA polymerase inhibitor",-0.26973,-0.707,0.812,1171,0.828,"cephalomannine",0.0904439707588247,0.0819696632151199,FALSE
+"H2009","Pearson.est","DNA synthesis inhibitor",-0.46491,-1.25,0.231,1094,0.666,"cisplatin, artemisinin, nelarabine, estramustine.phosphate, capecitabine, azodicarbonamide, CB.10.277",0.636388020107856,0.176525770829699,FALSE
+"H2009","Pearson.est","dopamine receptor antagonist",-0.39661,-1.04,0.391,911,0.722,"mesoridazine, clebopride, isofloxythepin, acetophenazine, ziprasidone, lurasidone, sertindole",0.407823242604133,0.141462802430361,FALSE
+"H2009","Pearson.est","estrogen receptor agonist",-0.37221,-1.03,0.426,1287,0.713,"estradiol, ethinyl.estradiol",0.370590400897281,0.146910470148134,FALSE
+"H2009","Pearson.est","estrogen receptor antagonist",-0.53495,-1.45,0.0905,800,0.429,"toremifene, fulvestrant, clomifene, danazol",1.0433514207948,0.367542707815276,FALSE
+"H2009","Pearson.est","FGFR inhibitor",0.71935,2.12,0.0174,213,0.13,"erdafitinib, MK.2461, PD.173074, regorafenib, lenvatinib, dovitinib, nintedanib",1.7594507517174,0.886056647693163,TRUE
+"H2009","Pearson.est","FLT3 inhibitor",0.5079,1.51,0.0891,314,0.196,"sunitinib, tandutinib, ponatinib, ENMD.2076, midostaurin, dovitinib, tozasertib, sorafenib, GTP.14564, tyrphostin.AG.1296",1.05012229596313,0.707743928643524,FALSE
+"H2009","Pearson.est","glucocorticoid receptor agonist",-0.54618,-1.49,0.0697,919,0.398,"fluocinolone.acetonide, flumethasone.pivalate, beclomethasone.dipropionate, flumethasone, ciclesonide, prednisolone.hemisuccinate, prednisolone, clobetasol.propionate, fluorometholone, methylprednisolone, desonide, deflazacort, fludroxycortide, halcinonide, triamcinolone",1.15676722190199,0.400116927926312,FALSE
+"H2009","Pearson.est","glutamate receptor antagonist",-0.34517,-0.93,0.523,976,0.712,"kynurenic.acid, diazooxonorleucine, CPP, ACDPP, JNJ.16259685",0.281498311132726,0.147520006363144,FALSE
+"H2009","Pearson.est","glycogen synthase kinase inhibitor",-0.27832,-0.752,0.748,984,0.834,"CHIR.99021, indirubin, kenpaullone",0.126098402135539,0.0788339493622613,FALSE
+"H2009","Pearson.est","growth factor receptor inhibitor",0.22308,0.657,0.864,76,0.955,"danusertib",0.0634862575211067,0.0199966284162537,FALSE
+"H2009","Pearson.est","HDAC inhibitor",-0.49665,-1.33,0.164,897,0.58,"nexturastat.a, trichostatin.a, tacedinaline, SB.939, RGFP966, AR.42, belinostat, panobinostat, ACY.1215, M.344, PCI.24781, resminostat, vorinostat, entinostat, givinostat, chidamide",0.785156151952302,0.236572006437063,FALSE
+"H2009","Pearson.est","histamine receptor antagonist",-0.3637,-0.98,0.479,761,0.698,"lafutidine, tecastemizole, cimetidine, levocetirizine, ranitidine, cyproheptadine, tiotidine, terfenadine, pheniramine, nizatidine, famotidine, epinastine",0.319664486585437,0.156144577376839,FALSE
+"H2009","Pearson.est","HSP inhibitor",0.19717,0.576,0.927,1092,1,"XL888, tanespimycin, NVP.AUY922, NMS.E973, ganetespib, SNX.2112, alvespimycin, VER.49009, PU.H71, guanidine, KW.2478, BIIB021, SNX.5422",0.0329202658555029,0,FALSE
+"H2009","Pearson.est","JAK inhibitor",-0.15344,-0.417,0.991,908,0.995,"CEP.33779, TG.101209, LY2784544, WHI.P154, filgotinib",0.00392634551472468,0.00217691925427455,FALSE
+"H2009","Pearson.est","KIT inhibitor",0.69843,2.03,0.0145,399,0.0816,"sunitinib, tandutinib, regorafenib, pazopanib, cediranib, lenvatinib, midostaurin, vatalanib, KI.8751, sorafenib, dasatinib, motesanib, OSI.930, masitinib, telatinib",1.83863199776503,1.08830984124614,TRUE
+"H2009","Pearson.est","MEK inhibitor",0.1806,0.53,0.973,1115,0.969,"BIX.02188, PD.318088, MEK162, Ro.4987655, AS.703026, PD.184352, PD.0325901, selumetinib, cobimetinib, AZD8330, TAK.733, trametinib, arctigenin, MEK1.2.inhibitor, PD.198306, U.0126, nobiletin",0.0118871597316481,0.0136762229492347,FALSE
+"H2009","Pearson.est","MET inhibitor",0.36926,1.09,0.348,116,0.584,"INC.280, NVP.BVU972",0.458420756053419,0.233587152887601,FALSE
+"H2009","Pearson.est","microtubule inhibitor",0.51264,1.56,0.0636,246,0.175,"vinblastine, vinflunine, podophyllotoxin, D.64131, triclabendazole, colchicine",1.19654288435159,0.756961951313706,FALSE
+"H2009","Pearson.est","mTOR inhibitor",-0.3408,-0.921,0.532,774,0.683,"palomid.529, LY3023414, torin.1, LY303511, ku.0063794, temsirolimus, PP242, WAY.600, GDC.0980, AZD2014, AZD8055, torin.2, MLN0128, PF.05212384, PF.04691502, OSI.027, XL388",0.274088367704952,0.165579296318467,FALSE
+"H2009","Pearson.est","NFkB pathway inhibitor",-0.34351,-0.939,0.498,766,0.72,"curcumin, parthenolide, Ro.106.9920, EVP4593, BAY.11.7082, IKK.2.inhibitor.V, bindarit, parthenolide....",0.302770657240282,0.142667503568732,FALSE
+"H2009","Pearson.est","opioid receptor agonist",-0.49318,-1.36,0.146,929,0.564,"trimebutine, ADL5859, cebranopadol, spiradoline",0.835647144215563,0.248720896016658,FALSE
+"H2009","Pearson.est","p38 MAPK inhibitor",-0.57096,-1.56,0.0469,1187,0.853,"SB.239063, SB.242235, talmapimod, TAK.715",1.32882715728492,0.069050968832477,FALSE
+"H2009","Pearson.est","PARP inhibitor",-0.57639,-1.54,0.0614,942,0.706,"E7449, talazoparib, endo.IWR.1, AZD2461, olaparib, niraparib",1.21183162885883,0.151195298948196,FALSE
+"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.7051,2.05,0.0118,255,0.0929,"SU014813, sunitinib, CP.673451, crenolanib, tandutinib, linifanib, regorafenib, ponatinib, axitinib, pazopanib, lenvatinib, dovitinib, nintedanib, vatalanib, KI.8751, sorafenib, dasatinib",1.92811799269387,1.03198428600636,TRUE
+"H2009","Pearson.est","phosphatase inhibitor",0.23371,0.68,0.817,158,0.957,"CID.5458317, BVT.948",0.0877779434675845,0.0190880622231565,FALSE
+"H2009","Pearson.est","phosphodiesterase inhibitor",-0.36355,-0.987,0.446,915,0.711,"avanafil, cilostamide, YM.976, zardaverine, anagrelide",0.350665141287858,0.148130399270234,FALSE
+"H2009","Pearson.est","PI3K inhibitor",0.18387,0.549,0.962,172,0.989,"buparlisib, idelalisib, SB.2343, ZSTK.474, GDC.0941",0.0168249279621871,0.0048037084028206,FALSE
+"H2009","Pearson.est","PLK inhibitor",0.63352,1.84,0.0379,295,0.108,"BI.2536, rigosertib, HMN.214, volasertib",1.42136079003193,0.96657624451305,TRUE
+"H2009","Pearson.est","potassium channel blocker",-0.56442,-1.51,0.0746,956,0.54,"dofetilide, meglitinide, mepivacaine",1.12726117252733,0.267606240177031,FALSE
+"H2009","Pearson.est","progesterone receptor agonist",-0.42879,-1.14,0.282,954,0.654,"norethindrone.acetate, melengestrol.acetate, danazol, dienogest",0.549750891680639,0.184422251675733,FALSE
+"H2009","Pearson.est","proteasome inhibitor",0.78033,2.34,0,185,0.0505,"bortezomib, ixazomib.citrate, carfilzomib, ixazomib, MG.132, delanzomib, oprozomib",Inf,1.29670862188134,TRUE
+"H2009","Pearson.est","protein synthesis inhibitor",0.47859,1.43,0.106,171,0.242,"thiostrepton, anguidine, bruceantin, mercaptopurine, harringtonine, cycloheximide",0.97469413473523,0.616184634019569,FALSE
+"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.32738,-0.884,0.595,1003,0.72,"tyrphostin.A9, rheochrysidin, PP.121",0.22548303427145,0.142667503568732,FALSE
+"H2009","Pearson.est","RAF inhibitor",0.28104,0.861,0.64,979,0.78,"regorafenib, sorafenib, CEP.32496, TAK.632, AZ.628, PLX.4720, SB.590885, GDC.0879, dabrafenib, LGX818, vemurafenib, RAF265",0.193820026016113,0.10790539730952,FALSE
+"H2009","Pearson.est","RET tyrosine kinase inhibitor",0.62312,1.86,0.0414,252,0.115,"cabozantinib, sunitinib, regorafenib, sorafenib",1.3829996588791,0.939302159646388,TRUE
+"H2009","Pearson.est","retinoid receptor agonist",-0.26681,-0.72,0.804,872,0.833,"bexarotene, CD.437, AM.580",0.0947439512515487,0.0793549985932124,FALSE
+"H2009","Pearson.est","ribonucleotide reductase inhibitor",0.27482,0.802,0.687,109,0.828,"LY2334737, cladribine",0.16304326294045,0.0819696632151199,FALSE
+"H2009","Pearson.est","serotonin receptor antagonist",-0.59051,-1.59,0.0442,1038,1,"SB.228357, lerisetron, ziprasidone, pirenperone, lurasidone, sertindole, tropisetron",1.35457773065091,0,FALSE
+"H2009","Pearson.est","sodium channel blocker",-0.3746,-1.01,0.42,916,0.723,"A.803467, triamterene, mexiletine, lappaconite, butamben, mepivacaine",0.3767507096021,0.140861702705469,FALSE
+"H2009","Pearson.est","src inhibitor",0.34199,1,0.425,896,0.594,"KX2.391, dasatinib, PP.2, masitinib, PP.1, saracatinib, ZM.306416, bosutinib, TG.100572",0.371611069949688,0.226213555018806,FALSE
+"H2009","Pearson.est","sterol demethylase inhibitor",-0.2719,-0.725,0.807,900,0.848,"posaconazole, terconazole",0.0931264652779296,0.0716041477432862,FALSE
+"H2009","Pearson.est","TGF beta receptor inhibitor",-0.44492,-1.19,0.265,757,0.627,"adaprev, SB.431542, D.4476",0.576754126063192,0.202732459169284,FALSE
+"H2009","Pearson.est","thymidylate synthase inhibitor",-0.66164,-1.77,0.0182,1205,0.761,"capecitabine, carmofur",1.73992861201493,0.118615343229427,FALSE
+"H2009","Pearson.est","topoisomerase inhibitor",0.54886,1.65,0.0316,216,0.162,"voreloxin, idarubicin, valrubicin, mitoxantrone, amsacrine, TAS.103, etoposide, doxorubicin, teniposide, licochalcone.a, daunorubicin, dexrazoxane, epirubicin",1.5003129173816,0.790484985457369,TRUE
+"H2009","Pearson.est","tubulin polymerization inhibitor",0.66033,1.98,0.0271,289,0.0844,"vinblastine, BNC105, CYT.997, mebendazole, vindesine, taltobulin, verubulin, KX2.391, podophyllotoxin, oxibendazole, vincristine, fenbendazole, fosbretabulin, parbendazole, flubendazole, dolastatin.10, ABT.751",1.56703070912559,1.07365755337434,TRUE
+"H2009","Pearson.est","tyrosine kinase inhibitor",0.36255,1.08,0.347,376,0.569,"cabozantinib, sunitinib, UNC2250, bafetinib, regorafenib, aminopurvalanol.a, BMS.599626, NVP.TAE226, sorafenib, dasatinib, GTP.14564, AMG.208, hypericin, apatinib",0.459670525209126,0.244887733604929,FALSE
+"H2009","Pearson.est","VEGFR inhibitor",0.56038,1.64,0.0632,291,0.154,"SU014813, cabozantinib, sunitinib, MK.2461, PD.173074, linifanib, MGCD.265, regorafenib, axitinib, tivozanib, ENMD.2076, pazopanib, cediranib, lenvatinib, dovitinib, nintedanib, vatalanib, KI.8751, sorafenib, golvatinib, foretinib",1.19928292171761,0.812479279163537,FALSE
+"H2009","Pearson.est","vitamin D receptor agonist",0.52109,1.57,0.0531,124,0.181,"tacalcitol, alfacalcidol, doxercalciferol",1.27490547891853,0.742321425130815,FALSE
+"H2126","Pearson.est","EGFR inhibitor",0.61179,1.55,0.056,348,0.331,"vandetanib, CP.724714, AZD8931, CUDC.101, icotinib, XL.647, gefitinib, lapatinib, neratinib, WZ.4002, erlotinib, BIBU.1361, BMS.690514, rociletinib, poziotinib, pelitinib, ARRY.334543, dacomitinib, FERb.033, osimertinib, CGP.52411, PD.168393, afatinib, AST.1306, WZ.3146, canertinib, BMS.599626",1.2518119729938,0.480172006224281,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",0.60069,1.51,0.0715,375,0.338,"ponatinib, dasatinib, flumatinib, metatinib, tozasertib, GZD824, nilotinib, KW.2449, ZM.306416",1.14569395819892,0.471083299722345,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",0.60837,1.55,0.054,383,0.331,"pilocarpine, xanomeline, nefiracetam",1.26760624017703,0.480172006224281,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",0.55623,1.41,0.102,409,0.449,"dicycloverine, diphemanil, methscopolamine, darifenacin",0.991399828238082,0.347753658996677,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",0.46684,1.17,0.285,45,0.569,"sulmazole",0.54515513999149,0.244887733604929,FALSE
+"H2126","Pearson.est","adrenergic receptor agonist",0.28327,0.726,0.788,366,0.926,"buphenine, oxymetazoline, A61603, epinephrine, clenbuterol, isoetharine",0.103473782510445,0.0333890133180656,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",0.34888,0.9,0.584,458,0.818,"propranolol, pindolol, dihydroergocristine, metoprolol, idazoxan, practolol, RS.17053, atipamezole, naftidrofuryl, vincamine",0.233587152887601,0.087246696328677,FALSE
+"H2126","Pearson.est","AKT inhibitor",0.52511,1.32,0.16,429,0.551,"AT7867, uprosertib, palomid.529, ONC201, triciribine, GSK2110183, CCT128930",0.795880017344075,0.258848401148215,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41234,1.06,0.417,462,0.641,"AP26113, DMH1, CEP.37440, NVP.TAE684, AZD3463",0.379863945026242,0.193141970481183,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",-0.51129,-1.51,0.0969,1282,0.275,"RU.58841, bicalutamide",1.01367622294923,0.560667306169737,FALSE
+"H2126","Pearson.est","antioxidant",0.61827,1.57,0.0494,414,0.379,"taurine, benfotiamine, trolox, rutin",1.30627305107635,0.421360790031928,FALSE
+"H2126","Pearson.est","AP inhibitor",-0.75408,-2.14,0.00746,1290,0.0347,"LCL.161, GDC.0152, birinapant, idronoxil",2.12726117252733,1.45967052520913,TRUE
+"H2126","Pearson.est","ATPase inhibitor",0.37935,0.971,0.494,635,0.746,"digitoxin, digitoxigenin, omeprazole, blebbistatin...., ouabain, evodiamine, thonzonium, oligomycin.a, NMS.873",0.306273051076353,0.127261172527331,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.49381,1.27,0.202,702,0.575,"hesperadin, ENMD.2076, AMG900, MLN.8054, tozasertib, CYC116, danusertib, KW.2449, barasertib.HQPA, CCT129202, alisertib, AT.9283, MK.8745, PHA.680632, CCT137690, SNS.314, aurora.a.inhibitor.i, barasertib, GSK1070916, PF.03814735, ZM.447439",0.694648630553376,0.24033215531037,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.35964,-1.06,0.352,1155,0.514,"valnemulin, radezolid, dirithromycin, azithromycin",0.453457336521869,0.289036881004724,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",-0.3184,-0.92,0.519,1125,0.67,"finafloxacin, sarafloxacin, nadifloxacin, norfloxacin, trovafloxacin",0.284832642151542,0.173925197299174,FALSE
+"H2126","Pearson.est","BCL inhibitor",-0.2858,-0.854,0.63,1320,0.709,"ABT.737, venetoclax",0.200659450546418,0.149353764816933,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.6109,1.54,0.0388,320,0.315,"ponatinib, dasatinib, flumatinib, metatinib, tozasertib, GZD824, nilotinib",1.41116827440579,0.501689446210399,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",-0.42007,-1.22,0.208,1352,0.42,"temazepam, piperazine, gamma.aminobutyric.acid, eprinomectin",0.681936665037238,0.3767507096021,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",0.49891,1.27,0.188,541,0.575,"I.BET.762, JQ1...., OTX015",0.72584215073632,0.24033215531037,FALSE
+"H2126","Pearson.est","calcium channel blocker",0.46203,1.19,0.249,364,0.573,"penfluridol, cinnarazine, mibefradil, pranidipine, tetrandrine",0.603800652904264,0.24184537803261,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.343,0.874,0.623,17,0.824,"RS.504393",0.20551195334083,0.0840727883028842,FALSE
+"H2126","Pearson.est","CDK inhibitor",0.25773,0.665,0.862,624,0.927,"indirubin, P276.00, R547, PHA.848125, ribociclib, palbociclib, AZD5438, aminopurvalanol.a, AT.7519, alvocidib, arcyriaflavin.a, abemaciclib",0.0644927341752872,0.0329202658555029,FALSE
+"H2126","Pearson.est","CHK inhibitor",-0.63566,-1.87,0.0268,1185,0.113,"CHIR.124, AZD7762, PF.477736, SCH.900776",1.57186520597121,0.94692155651658,TRUE
+"H2126","Pearson.est","cyclooxygenase inhibitor",0.35172,0.91,0.591,241,0.818,"piroxicam, tepoxalin, suxibuzone, acetylsalicylsalicylic.acid, ramifenazone, FR.122047",0.228412519118745,0.087246696328677,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",0.65095,1.64,0.0235,433,0.339,"PF.4981517, morin, eplerenone, cobicistat",1.62893213772826,0.469800301796918,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.34296,0.878,0.627,307,0.837,"dacarbazine, TH.302, ifosfamide",0.202732459169284,0.07727454200674,FALSE
+"H2126","Pearson.est","DNA inhibitor",-0.35305,-0.983,0.413,1353,0.6,"sangivamycin, pibenzimol, nithiamide, chlorambucil",0.384049948343599,0.221848749616356,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",0.40856,1.04,0.408,469,0.643,"RG108, disulfiram",0.38933983691012,0.191789027075778,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",0.26508,0.674,0.851,305,0.934,"cephalomannine, menadione",0.0700704399154121,0.0296531237699066,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",0.21878,0.554,0.959,663,0.969,"CB.10.277, azodicarbonamide, nelarabine, estramustine.phosphate, anisomycin, cyclocytidine, altretamine, artesunate",0.0181813928293364,0.0136762229492347,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",0.2228,0.568,0.948,155,0.977,"UH.232...., clebopride",0.0231916626619338,0.0101054362812269,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",0.54821,1.39,0.116,96,0.46,"estradiol.cypionate, ethinyl.estradiol",0.935542010773082,0.337242168318426,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",0.41082,1.06,0.394,606,0.641,"tamoxifen, toremifene, raloxifene, clomifene, fulvestrant",0.404503778174426,0.193141970481183,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.32957,0.843,0.643,139,0.842,"PD.173074, orantinib",0.191789027075778,0.0746879085003505,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.5888,1.48,0.063,374,0.37,"midostaurin, ponatinib, sorafenib, ENMD.2076, GTP.14564, quizartinib, pacritinib, tozasertib, gilteritinib, KW.2449, lestaurtinib",1.20065945054642,0.431798275933005,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",0.31874,0.81,0.699,146,0.858,"methylprednisolone, betamethasone, fluticasone.propionate, prednisolone, dexamethasone.acetate",0.155522824254319,0.0665127121512946,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.41767,-1.2,0.259,1238,0.413,"diazooxonorleucine, CPP, CGP.37849, kynurenic.acid, JNJ.16259685, latrepirdine",0.586700235918748,0.384049948343599,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.42337,-1.19,0.262,1262,0.396,"CHIR.98014, LY2090314, CHIR.99021, kenpaullone",0.581698708680255,0.402304814074488,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.48476,1.21,0.24,620,0.556,"danusertib, lestaurtinib, PHA.848125, AZD3463, GSK1838705A",0.619788758288394,0.254925208417942,FALSE
+"H2126","Pearson.est","HCV inhibitor",-0.5657,-1.64,0.0395,1269,0.234,"PSI.7976, daclatasvir, Ro.9187",1.40340290437354,0.630784142589857,TRUE
+"H2126","Pearson.est","HDAC inhibitor",0.48541,1.21,0.254,485,0.556,"belinostat, resminostat, nexturastat.a, M.344, ACY.1215, panobinostat, chidamide, RG2833, vorinostat, RGFP966, mocetinostat, givinostat, tacedinaline, PCI.24781",0.595166283380062,0.254925208417942,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",0.47728,1.21,0.25,509,0.556,"pheniramine, tiotidine, ranitidine, BF2.649, lafutidine, terfenadine, ebastine, ICI.162846, levocetirizine, tecastemizole, famotidine",0.602059991327962,0.254925208417942,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",-0.44304,-1.26,0.196,1437,0.447,"lovastatin",0.707743928643524,0.349692476868064,FALSE
+"H2126","Pearson.est","HSP inhibitor",-0.233,-0.665,0.881,1316,0.867,"alvespimycin, SNX.2112, VER.49009",0.0550240915879521,0.0619809025237897,FALSE
+"H2126","Pearson.est","JAK inhibitor",0.4446,1.14,0.314,501,0.586,"ruxolitinib, pacritinib, PRT062070, CEP.33779, tozasertib, lestaurtinib, TG.101209, atiprimod, AZ960, AT.9283",0.503070351926785,0.232102383981909,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.46842,1.21,0.242,259,0.556,"midostaurin, masitinib, sorafenib, dasatinib, pazopanib, motesanib",0.616184634019569,0.254925208417942,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.56252,-1.59,0.0581,1223,0.239,"serdemetan, CGM097, AMG.232, idasanutlin",1.23582386760967,0.621602099051862,FALSE
+"H2126","Pearson.est","MEK inhibitor",-0.46123,-1.36,0.161,1157,0.36,"selumetinib, TAK.733, PD.318088, cobimetinib, AS.703026, PD.184352, trametinib, refametinib",0.79317412396815,0.443697499232713,FALSE
+"H2126","Pearson.est","MET inhibitor",-0.40796,-1.24,0.216,1275,0.431,"INC.280, PF.04217903",0.665546248849069,0.365522729839268,FALSE
+"H2126","Pearson.est","microtubule inhibitor",0.43088,1.08,0.376,589,0.64,"secnidazole, cabazitaxel, D.64131, estramustine.phosphate, cytochalasin.b, vinflunine",0.424812155072339,0.193820026016113,FALSE
+"H2126","Pearson.est","mTOR inhibitor",0.37139,0.942,0.528,515,0.78,"GSK2126458, everolimus, temsirolimus, AZD2014, LY3023414, deforolimus, palomid.529, PI.103, WYE.125132, AZD8055, NVP.BEZ235, torin.1, MLN0128, torin.2, WYE.354, PF.05212384",0.277366077466188,0.10790539730952,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.24662,-0.728,0.799,1136,0.824,"curcumin, IKK.2.inhibitor.V, bortezomib, tyloxapol, bindarit",0.0974532206860086,0.0840727883028842,FALSE
+"H2126","Pearson.est","opioid receptor agonist",0.49199,1.24,0.233,735,0.588,"salvinorin.a, spiradoline, BW.180C, ADL5859, trimebutine, cebranopadol",0.632644078973981,0.230622673923862,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",0.70848,1.78,0.0202,379,0.306,"VX.702, TAK.715, SB.242235, talmapimod, CMPD.1",1.69464863055338,0.51427857351842,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.45429,1.16,0.281,790,0.57,"PJ.34, E7449, AZD2461, olaparib, endo.IWR.1, niraparib, talazoparib, AG.14361",0.55129368009492,0.244125144327509,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.46661,1.18,0.262,259,0.571,"masitinib, ponatinib, sorafenib, orantinib, dasatinib, axitinib, pazopanib, motesanib",0.581698708680255,0.243363891754152,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.26917,0.683,0.846,511,0.96,"sodium.stibogluconate, mycophenolic.acid, menadione, bis.maltolato.oxovanadium.IV., CID.5458317",0.0726296369609765,0.0177287669604316,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",0.5398,1.36,0.131,380,0.496,"YM.976, GSK256066, cilostamide, enoximone",0.882728704344236,0.304518323509803,FALSE
+"H2126","Pearson.est","PI3K inhibitor",0.32877,0.837,0.667,778,0.833,"GSK2126458, LY3023414, YM.201636, alpelisib, PI.103, GDC.0941, NVP.BEZ235, buparlisib, PF.05212384, GDC.0980, PKI.179, TG.100713, taselisib, BGT226, PI.828, PIK.75, voxtalisib, CH5132799, PI3K.IN.2, CUDC.907",0.175874166083451,0.0793549985932124,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.42473,1.09,0.362,764,0.641,"volasertib, NMS.1286937, HMN.214, GW.843682X, rigosertib, GSK461364",0.441291429466834,0.193141970481183,FALSE
+"H2126","Pearson.est","potassium channel blocker",-0.30585,-0.866,0.586,1314,0.726,"dofetilide, mepivacaine",0.232102383981909,0.139063379299906,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",-0.37267,-1.07,0.363,1281,0.533,"clofibrate, pterostilbene",0.440093374963888,0.273272790973428,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",-0.5085,-1.5,0.076,1344,0.251,"danazol, norgestrel, norethindrone.acetate",1.11918640771921,0.600326278518962,FALSE
+"H2126","Pearson.est","proteasome inhibitor",-0.75506,-2.2,0,1082,0.0347,"ixazomib.citrate, ixazomib, delanzomib, bortezomib, MG.132, ONX.0914, carfilzomib, oprozomib",Inf,1.45967052520913,TRUE
+"H2126","Pearson.est","protein synthesis inhibitor",0.26486,0.677,0.848,159,0.948,"tedizolid.phosphate, cycloheximide",0.0716041477432862,0.0231916626619338,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",0.57641,1.46,0.0803,443,0.379,"CP.724714, NVP.TAE226, PP.121, BMS.599626, AV.412",1.09528445472132,0.421360790031928,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.29654,0.75,0.789,108,0.912,"SB.590885, sorafenib",0.10292299679058,0.0400051616715838,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.7394,1.85,0.00974,208,0.351,"vandetanib, sorafenib, apatinib",2.01144104312138,0.454692883534176,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.30224,0.766,0.764,497,0.908,"adapalene, CD.437, bexarotene, adarotene",0.11690664142431,0.0419141514789149,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",-0.28654,-0.84,0.611,1302,0.696,"cytarabine, cladribine",0.213958789757446,0.157390760389438,FALSE
+"H2126","Pearson.est","serotonin receptor antagonist",0.20012,0.507,0.99,51,0.975,"SB.216641",0.00436480540245009,0.0109953843014632,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.41512,1.05,0.411,290,0.642,"oxcarbazepine, brivaracetam, benzocaine, quinidine, A.803467",0.386158178123931,0.192464971931147,FALSE
+"H2126","Pearson.est","src inhibitor",0.63945,1.62,0.0321,375,0.323,"masitinib, saracatinib, dasatinib, TG.100572, ZM.306416",1.49349496759513,0.490797477668897,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.66141,1.72,0.0224,64,0.238,"lanoconazole, ketoconazole, chlormidazole",1.64975198166584,0.623423042943488,TRUE
+"H2126","Pearson.est","TGF beta receptor inhibitor",0.68001,1.72,0.0124,339,0.238,"D.4476, adaprev, SB.431542, repsox",1.90657831483776,0.623423042943488,TRUE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.33925,0.863,0.618,136,0.825,"ftorafur",0.209011524911184,0.0835460514500749,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.23898,0.603,0.901,577,0.969,"doxorubicin, amsacrine, mitoxantrone, epirubicin, etoposide, valrubicin, amonafide, dexrazoxane, voreloxin, rubitecan",0.045275209020937,0.0136762229492347,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.43504,1.09,0.344,723,0.641,"nocodazole, epothilone.d, vincristine, ABT.751, fosbretabulin, paclitaxel, taltobulin, epothilone.b, docetaxel, indibulin, BNC105, albendazole, mebendazole, vindesine, dolastatin.10, parbendazole, flubendazole, plinabulin, vinorelbine, vinblastine",0.46344155742847,0.193141970481183,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",0.5243,1.31,0.172,208,0.543,"vandetanib, CP.724714, NVP.TAE226, sorafenib, GTP.14564, dasatinib, PP.121, apatinib",0.764471553092451,0.265200170411153,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",0.49558,1.24,0.228,375,0.588,"semaxanib, vandetanib, XL.647, sorafenib, ENMD.2076, PD.173074, orantinib, BMS.690514, axitinib, pazopanib, motesanib, SAR131675, TG.100572, tivozanib, ZM.306416",0.642065152999546,0.230622673923862,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.76081,-2.26,0,1091,0.0459,"calcitriol, tacalcitol, ercalcitriol, maxacalcitol, alfacalcidol, paricalcitol, doxercalciferol",Inf,1.33818731446274,TRUE
+"H3255","Pearson.est","EGFR inhibitor",0.15854,0.469,0.996,172,0.991,"dovitinib, icotinib, brigatinib, gefitinib, ARRY.334543, erlotinib, rociletinib",0.00174066157630127,0.00392634551472468,FALSE
+"H3255","Pearson.est","Abl kinase inhibitor",-0.33503,-0.887,0.601,1069,1,"ZM.306416, flumatinib, KW.2449, metatinib",0.22112552799726,0,FALSE
+"H3255","Pearson.est","acetylcholine receptor agonist",-0.45432,-1.23,0.223,826,0.801,"tremorine, nefiracetam, xanomeline, nicotine",0.651695136951839,0.0963674839157623,FALSE
+"H3255","Pearson.est","acetylcholine receptor antagonist",-0.5721,-1.53,0.0735,918,0.463,"darifenacin, diphemanil, hyoscyamine",1.1337126609158,0.334419008982047,FALSE
+"H3255","Pearson.est","adenosine receptor antagonist",-0.20525,-0.547,0.944,736,0.99,"PSB.1115, theophylline, sulmazole, istradefylline",0.025028005701931,0.00436480540245009,FALSE
+"H3255","Pearson.est","adrenergic receptor agonist",-0.3923,-1.06,0.383,846,0.982,"isoetharine, A61603, buphenine, norepinephrine, metaraminol, methyldopa, xylazine",0.416801226031377,0.00788851221305034,FALSE
+"H3255","Pearson.est","adrenergic receptor antagonist",-0.27974,-0.758,0.752,881,0.913,"dihydroergocristine, vincamine, atenolol...., atenolol......, oxprenolol, metoprolol, dronedarone, imiloxan",0.123782159408358,0.039529222465701,FALSE
+"H3255","Pearson.est","AKT inhibitor",0.26309,0.855,0.617,204,0.936,"uprosertib, AZD5363, AT7867, ONC201",0.209714835966758,0.0287241512618947,FALSE
+"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.32129,0.976,0.469,338,0.84,"brigatinib, alectinib, lorlatinib, SB.505124, crizotinib, NVP.TAE684",0.328827157284917,0.0757207139381184,FALSE
+"H3255","Pearson.est","antioxidant",-0.50424,-1.33,0.164,1047,0.632,"taurine, mesna, benfotiamine, rutin",0.785156151952302,0.199282921717615,FALSE
+"H3255","Pearson.est","AP inhibitor",-0.58639,-1.59,0.0597,1178,0.392,"birinapant, GDC.0152, tanshinone.i, embelin",1.22402566887063,0.406713932979543,FALSE
+"H3255","Pearson.est","ATPase inhibitor",0.22783,0.749,0.748,230,0.988,"omeprazole, evodiamine, digitoxigenin",0.126098402135539,0.00524305541237188,FALSE
+"H3255","Pearson.est","Aurora kinase inhibitor",-0.38298,-1.03,0.426,971,0.932,"SNS.314, danusertib, CCT137690, PF.03814735, PHA.680632, AT.9283, KW.2449, MK.8745, GSK1070916, CCT129202",0.370590400897281,0.0305840876460186,FALSE
+"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.66387,-1.79,0.00691,1253,0.636,"tedizolid, radezolid, josamycin, dirithromycin, tilmicosin",2.1605219526258,0.196542884351586,FALSE
+"H3255","Pearson.est","bacterial DNA gyrase inhibitor",0.23421,0.755,0.752,1087,1,"lomefloxacin, sparfloxacin, nadifloxacin, trovafloxacin, novobiocin, norfloxacin, finafloxacin, sarafloxacin",0.123782159408358,0,FALSE
+"H3255","Pearson.est","BCL inhibitor",0.32576,1.03,0.401,958,0.919,"oridonin, obatoclax, TW.37, venetoclax, gossypol, navitoclax, ABT.737, HA14.1",0.396855627379818,0.0366844886138887,FALSE
+"H3255","Pearson.est","Bcr.Abl kinase inhibitor",-0.19439,-0.515,0.963,1109,0.969,"flumatinib, metatinib",0.0163737128754655,0.0136762229492347,FALSE
+"H3255","Pearson.est","benzodiazepine receptor agonist",-0.20771,-0.556,0.937,861,1,"eprinomectin, nefiracetam, piperazine, lorazepam, temazepam, ivermectin",0.0282604091122217,0,FALSE
+"H3255","Pearson.est","bromodomain inhibitor",-0.39989,-1.07,0.382,1329,1,"OTX015, JQ1....",0.417936637088291,0,FALSE
+"H3255","Pearson.est","calcium channel blocker",-0.39452,-1.06,0.393,1227,0.982,"SKF.96365, mibefradil, cinnarazine",0.405607449624573,0.00788851221305034,FALSE
+"H3255","Pearson.est","CC chemokine receptor antagonist",-0.41879,-1.12,0.317,1269,1,"navarixin, PF.04136309",0.498940737782249,0,FALSE
+"H3255","Pearson.est","CDK inhibitor",0.2276,0.708,0.817,352,0.96,"abemaciclib, ribociclib, indirubin, indisulam, R547, dinaciclib, PHA.848125, AT.7519, P276.00",0.0877779434675845,0.0177287669604316,FALSE
+"H3255","Pearson.est","CHK inhibitor",-0.6328,-1.68,0.0211,1010,0.341,"SB.218078, SCH.900776, CHIR.124, PF.477736, AZD7762",1.67571754470231,0.467245621007502,FALSE
+"H3255","Pearson.est","cyclooxygenase inhibitor",-0.29705,-0.779,0.737,662,0.925,"ketoprofen, ramifenazone, amfenac, aspirin, phenylbutazone, piroxicam, FK.3311, indoprofen, FR.122047, phenazone, acetylsalicylsalicylic.acid, suxibuzone, naproxen",0.132532512140949,0.0338582672609674,FALSE
+"H3255","Pearson.est","cytochrome P450 inhibitor",-0.30168,-0.794,0.724,1014,0.946,"clotrimazole, cobicistat, morin",0.140261433802853,0.0241088635982073,FALSE
+"H3255","Pearson.est","DNA alkylating agent",-0.37024,-0.986,0.469,951,0.898,"melphalan, carboplatin, carmustine, satraplatin, streptozotocin, ifosfamide, cyclophosphamide, temozolomide",0.328827157284917,0.0467236633326956,FALSE
+"H3255","Pearson.est","DNA inhibitor",-0.4167,-1.11,0.344,927,1,"oxaliplatin, nimorazole, nithiamide, melphalan, carboplatin, bendamustine, carmustine, teroxirone, mechlorethamine, busulfan",0.46344155742847,0,FALSE
+"H3255","Pearson.est","DNA methyltransferase inhibitor",-0.31866,-0.864,0.649,998,1,"RG108, SGI.1027, fdcyd",0.187755303199631,0,FALSE
+"H3255","Pearson.est","DNA polymerase inhibitor",-0.59694,-1.62,0.0347,1012,0.399,"idoxuridine, foscarnet, cidofovir, adefovir.dipivoxil, trifluridine",1.45967052520913,0.399027104313252,FALSE
+"H3255","Pearson.est","DNA synthesis inhibitor",-0.38142,-1.02,0.43,779,0.885,"mitomycin.c, CB.10.277, azodicarbonamide, enocitabine, artemisinin, artesunate, floxuridine, nelarabine",0.366531544420413,0.0530567293021746,FALSE
+"H3255","Pearson.est","dopamine receptor antagonist",-0.24624,-0.658,0.855,791,0.957,"UH.232...., acetophenazine, piperacetazine, isofloxythepin, amisulpride, domperidone, raclopride",0.0680338852718274,0.0190880622231565,FALSE
+"H3255","Pearson.est","estrogen receptor agonist",-0.51548,-1.41,0.113,960,0.58,"equol, PPT, estradiol.cypionate, estrone, estradiol",0.94692155651658,0.236572006437063,FALSE
+"H3255","Pearson.est","estrogen receptor antagonist",-0.30441,-0.805,0.699,653,0.977,"tamoxifen, clomifene, fulvestrant, danazol, raloxifene",0.155522824254319,0.0101054362812269,FALSE
+"H3255","Pearson.est","FGFR inhibitor",0.3454,1.09,0.348,54,0.849,"dovitinib, regorafenib, PD.173074",0.458420756053419,0.0710923097560473,FALSE
+"H3255","Pearson.est","FLT3 inhibitor",0.43744,1.34,0.16,42,0.554,"sorafenib, ENMD.2076, dovitinib, sunitinib, pacritinib",0.795880017344075,0.25649023527157,FALSE
+"H3255","Pearson.est","glucocorticoid receptor agonist",-0.37853,-1.01,0.447,744,0.875,"piretanide, fluocinolone.acetonide, difluprednate, halcinonide, flumethasone, rimexolone, beclomethasone.dipropionate, fluorometholone, fluticasone.propionate, halobetasol.propionate, prednisolone, triamcinolone, prednisolone.hemisuccinate, methylprednisolone",0.349692476868064,0.0579919469776868,FALSE
+"H3255","Pearson.est","glutamate receptor antagonist",0.22719,0.723,0.823,201,0.982,"CPP, MTPG, felbamate, CGP.37849",0.0846001647877302,0.00788851221305034,FALSE
+"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.2997,-0.797,0.708,1148,0.965,"CHIR.98014, tideglusib, kenpaullone",0.149966742310231,0.0154726866562074,FALSE
+"H3255","Pearson.est","growth factor receptor inhibitor",-0.38846,-1.04,0.419,896,0.947,"GW.441756, AZD3463, danusertib, GSK1904529A, lestaurtinib",0.377785977033705,0.0236500209967266,FALSE
+"H3255","Pearson.est","HDAC inhibitor",0.41179,1.26,0.189,266,0.56,"vorinostat, tacedinaline, resminostat, scriptaid, romidepsin, entinostat, JNJ.26481585, nexturastat.a, panobinostat, AR.42, dacinostat",0.723538195826756,0.2518119729938,FALSE
+"H3255","Pearson.est","histamine receptor antagonist",-0.2882,-0.785,0.714,703,0.938,"ICI.162846, BF2.649, levocetirizine, ebastine, pheniramine, tecastemizole, famotidine, cimetidine, terfenadine, nizatidine, ranitidine",0.146301788223826,0.0277971616209356,FALSE
+"H3255","Pearson.est","HSP inhibitor",-0.30528,-0.824,0.673,1187,1,"guanidine, SNX.5422, XL888, NMS.E973",0.171984935776023,0,FALSE
+"H3255","Pearson.est","JAK inhibitor",-0.49323,-1.33,0.141,1124,0.632,"AT.9283, TG.101348, baricitinib, TG.101209, LY2784544, lestaurtinib, CEP.33779, atiprimod",0.85078088734462,0.199282921717615,FALSE
+"H3255","Pearson.est","KIT inhibitor",0.5161,1.61,0.0376,183,0.503,"sorafenib, sunitinib, regorafenib, motesanib, imatinib, vatalanib",1.42481215507234,0.298432014944073,FALSE
+"H3255","Pearson.est","MDM inhibitor",-0.37274,-1.02,0.433,615,0.885,"CGM097, serdemetan, RITA, AMG.232, nutlin.3",0.363512103646635,0.0530567293021746,FALSE
+"H3255","Pearson.est","MEK inhibitor",-0.46026,-1.26,0.197,776,0.771,"trametinib, AZD8330, PD.98059, refametinib, U.0126, PD.318088, PD.184352, PD.0325901, TAK.733, selumetinib, AS.703026, MEK162, MEK1.2.inhibitor, arctigenin",0.705533773838407,0.112945621949043,FALSE
+"H3255","Pearson.est","MET inhibitor",0.67423,2.11,0.00837,300,0.104,"LY2801653, PF.04217903, INC.280, AMG458",2.07727454200674,0.98296666070122,TRUE
+"H3255","Pearson.est","microtubule inhibitor",0.41649,1.29,0.14,831,0.569,"cytochalasin.b, colchicine, secnidazole, vinblastine, triclabendazole, vinflunine, cabazitaxel, estramustine.phosphate, D.64131, podophyllotoxin",0.853871964321762,0.244887733604929,FALSE
+"H3255","Pearson.est","mTOR inhibitor",-0.39896,-1.06,0.375,902,0.982,"ku.0063794, voxtalisib, WYE.125132, sirolimus, MLN0128, everolimus, LY303511, temsirolimus, AZD2014, torin.1, LY3023414, torin.2, PP242, PKI.179, deforolimus, AZD8055",0.425968732272281,0.00788851221305034,FALSE
+"H3255","Pearson.est","NFkB pathway inhibitor",0.22033,0.679,0.871,283,0.917,"BAY.11.7082, curcumin, parthenolide...., bindarit",0.0599818449923368,0.0376306643299789,FALSE
+"H3255","Pearson.est","opioid receptor agonist",-0.66194,-1.76,0.0137,1288,0.392,"ADL5859, cebranopadol",1.86327943284359,0.406713932979543,FALSE
+"H3255","Pearson.est","p38 MAPK inhibitor",-0.56341,-1.52,0.0686,1081,0.426,"talmapimod, VX.702, SB.239063, CMPD.1, SB.242235",1.16367588429325,0.370590400897281,FALSE
+"H3255","Pearson.est","PARP inhibitor",-0.27392,-0.732,0.782,851,0.929,"endo.IWR.1, AZD2461, E7449",0.106793246940152,0.0319842860063582,FALSE
+"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.53436,1.58,0.0656,219,0.42,"sorafenib, axitinib, dovitinib, sunitinib, regorafenib, motesanib, SU014813, imatinib, CP.673451, vatalanib, trapidil",1.18309616062434,0.3767507096021,FALSE
+"H3255","Pearson.est","phosphatase inhibitor",-0.2027,-0.54,0.955,868,0.975,"alexidine, BVT.948, mycophenolate.mofetil, mycophenolic.acid",0.0199966284162537,0.0109953843014632,FALSE
+"H3255","Pearson.est","phosphodiesterase inhibitor",0.32397,1.02,0.385,128,0.865,"trequinsin, enoximone, anagrelide",0.414539270491499,0.0629838925351858,FALSE
+"H3255","Pearson.est","PI3K inhibitor",0.21982,0.701,0.862,253,0.928,"idelalisib, GSK2126458, pilaralisib, YM.201636, PI.103, buparlisib, AZD6482, CH5132799, PI.828, SB.2343",0.0644927341752872,0.0324520237811379,FALSE
+"H3255","Pearson.est","PLK inhibitor",0.27961,0.865,0.585,264,0.971,"GW.843682X, GSK461364, rigosertib",0.23284413391782,0.0127807700919951,FALSE
+"H3255","Pearson.est","potassium channel blocker",0.18852,0.591,0.93,1151,0.97,"dofetilide, meglitinide, ibutilide, oleoylethanolamide, mepivacaine, ML133",0.0315170514460649,0.0132282657337552,FALSE
+"H3255","Pearson.est","PPAR receptor agonist",-0.38895,-1.04,0.416,1291,0.947,"S26948, clofibrate",0.380906669373257,0.0236500209967266,FALSE
+"H3255","Pearson.est","progesterone receptor agonist",-0.28552,-0.772,0.757,800,0.914,"melengestrol.acetate, norgestrel, danazol, tanaproget, nomegestrol.acetate",0.120904120499927,0.0390538042661686,FALSE
+"H3255","Pearson.est","proteasome inhibitor",-0.51001,-1.38,0.122,976,0.608,"oprozomib, bortezomib, ixazomib, ixazomib.citrate, delanzomib",0.913640169325252,0.216096420727265,FALSE
+"H3255","Pearson.est","protein synthesis inhibitor",0.2771,0.847,0.657,854,0.9,"brefeldin.a, cycloheximide, harringtonine, chloramphenicol.palmitate, emetine, anguidine, homoharringtonine, azomycin..2.nitroimidazole., bruceantin, tedizolid.phosphate, puromycin, mercaptopurine, clofoctol, thiostrepton, florfenicol, clindamycin.phosphate",0.182434630440219,0.0457574905606751,FALSE
+"H3255","Pearson.est","protein tyrosine kinase inhibitor",-0.54805,-1.47,0.0839,824,0.485,"CP.724714, NVP.TAE226, PP.121, tyrphostin.A9, BMS.599626, mubritinib, AV.412",1.0762380391713,0.314258261397736,FALSE
+"H3255","Pearson.est","RAF inhibitor",-0.21641,-0.593,0.926,825,0.999,"SB.590885, PLX.4720, GDC.0879, TAK.632, CEP.32496, LGX818, dabrafenib",0.0333890133180656,0.000434511774017692,FALSE
+"H3255","Pearson.est","RET tyrosine kinase inhibitor",0.8246,2.58,0,43,0.00255,"sorafenib, sunitinib, cabozantinib, regorafenib",Inf,2.59345981956604,TRUE
+"H3255","Pearson.est","retinoid receptor agonist",0.49644,1.52,0.0988,137,0.421,"adapalene, bexarotene, AM.580",1.00524305541237,0.375717904164332,FALSE
+"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.35131,-0.936,0.53,657,0.943,"fludarabine.phosphate, fludarabine, cytarabine, LY2334737, triapine, gemcitabine, clofarabine",0.275724130399211,0.0254883072626717,FALSE
+"H3255","Pearson.est","serotonin receptor antagonist",-0.25932,-0.694,0.837,869,0.957,"SB.228357, RS.16566, lerisetron, SB.216641, SB.200646",0.07727454200674,0.0190880622231565,FALSE
+"H3255","Pearson.est","sodium channel blocker",-0.30567,-0.815,0.682,753,0.984,"butamben, lappaconite, brivaracetam, oxcarbazepine, mepivacaine, triamterene, quinidine, ajmaline, benzethonium",0.166215625343521,0.00700490156865849,FALSE
+"H3255","Pearson.est","src inhibitor",-0.25107,-0.684,0.843,812,0.948,"TG.100572, KX2.391, PP.2, ZM.306416",0.0741724253752577,0.0231916626619338,FALSE
+"H3255","Pearson.est","sterol demethylase inhibitor",-0.30566,-0.825,0.683,1174,1,"lanoconazole, posaconazole",0.165579296318467,0,FALSE
+"H3255","Pearson.est","TGF beta receptor inhibitor",-0.64232,-1.73,0.0173,1352,0.321,"adaprev, SB.525334, LY2109761",1.7619538968712,0.493494967595128,FALSE
+"H3255","Pearson.est","thymidylate synthase inhibitor",-0.30585,-0.817,0.694,844,1,"ftorafur, carmofur, raltitrexed, trifluridine",0.158640529545145,0,FALSE
+"H3255","Pearson.est","topoisomerase inhibitor",-0.30546,-0.834,0.638,654,1,"nemorubicin, exatecan.mesylate, doxorubicin, etoposide.phosphate, amsacrine, etoposide, rubitecan, valrubicin, idarubicin, camptothecin, mitoxantrone, irinotecan, teniposide, topotecan, fleroxacin, amonafide, genz.644282, voreloxin, TAS.103, SN.38",0.195179321278838,0,FALSE
+"H3255","Pearson.est","tubulin polymerization inhibitor",0.32322,0.99,0.415,299,0.868,"mebendazole, vinorelbine, nocodazole, docetaxel, verubulin, paclitaxel, fosbretabulin, parbendazole, vindesine, BNC105, vincristine",0.381951903287907,0.0614802748235081,FALSE
+"H3255","Pearson.est","tyrosine kinase inhibitor",0.311,0.959,0.494,88,0.82,"sorafenib, sunitinib, cabozantinib, regorafenib, tyrphostin.AG.99",0.306273051076353,0.0861861476162833,FALSE
+"H3255","Pearson.est","VEGFR inhibitor",0.47776,1.4,0.11,209,0.526,"sorafenib, axitinib, ENMD.2076, dovitinib, sunitinib, cabozantinib, regorafenib, motesanib, SU014813, PD.173074, tivozanib, semaxanib, vatalanib, MK.2461, MGCD.265",0.958607314841775,0.279014255846261,FALSE
+"H3255","Pearson.est","vitamin D receptor agonist",-0.36014,-0.963,0.497,880,0.915,"alfacalcidol, calcitriol, doxercalciferol, tacalcitol, ercalcitriol",0.303643611266668,0.0385789059335517,FALSE
+"H358","Pearson.est","EGFR inhibitor",-0.37886,-1.1,0.321,867,0.517,"WZ.4002, BIBU.1361, erlotinib, tyrphostin.AG.1478, lapatinib, dacomitinib, AZD8931, ARRY.334543, FERb.033, afatinib, pelitinib, poziotinib, PD.168393, dovitinib, osimertinib, neratinib, tyrphostin.AG.494, vandetanib, BIBX.1382, BMS.690514, canertinib",0.493494967595128,0.286509456906058,FALSE
+"H358","Pearson.est","Abl kinase inhibitor",0.50577,1.33,0.154,414,0.463,"GZD824, metatinib, flumatinib, KW.2449, imatinib, tozasertib, nilotinib",0.812479279163537,0.334419008982047,FALSE
+"H358","Pearson.est","adenosine receptor antagonist",-0.7832,-2.23,0.00279,1118,0.0226,"theophylline, sulmazole, SCH.58261, PSB.1115",2.5543957967264,1.6458915608526,TRUE
+"H358","Pearson.est","adrenergic receptor agonist",-0.49644,-1.43,0.129,1141,0.484,"ritodrine, A61603, isoetharine, xylazine",0.889410289700751,0.315154638355588,FALSE
+"H358","Pearson.est","adrenergic receptor antagonist",-0.29941,-0.837,0.658,1013,0.789,"pindolol, RS.17053, prazosin, atenolol....",0.181774106386044,0.10292299679058,FALSE
+"H358","Pearson.est","AKT inhibitor",0.39081,1.04,0.421,459,0.639,"GDC.0068, MK.2206, A.674563, CCT128930, AZD5363, uprosertib, triciribine",0.375717904164332,0.1944991418416,FALSE
+"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.48722,-1.38,0.133,1031,0.494,"GW.788388, AZD3463, CEP.37440, crizotinib, SB.505124",0.876148359032914,0.306273051076353,FALSE
+"H358","Pearson.est","antioxidant",-0.82175,-2.34,0,1056,0.0164,"rutin, taurine, chlorogenic.acid, benfotiamine, trolox",Inf,1.7851561519523,TRUE
+"H358","Pearson.est","ATPase inhibitor",0.56153,1.48,0.0887,482,0.624,"ouabain, NMS.873, blebbistatin...., thonzonium, digitoxigenin",1.05207638016827,0.204815410317576,FALSE
+"H358","Pearson.est","Aurora kinase inhibitor",0.65107,1.72,0.024,371,1,"barasertib.HQPA, SNS.314, CYC116, PF.03814735, danusertib, AMG900, ZM.447439, MK.5108, CCT129202, ENMD.2076, barasertib, TAK.901, CCT137690, PHA.680632, aurora.a.inhibitor.i, KW.2449, tozasertib, AT.9283",1.61978875828839,0,FALSE
+"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.2921,0.785,0.729,8,0.811,"tedizolid",0.137272471682025,0.090979145788844,FALSE
+"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.36916,0.988,0.448,319,0.68,"trovafloxacin, sarafloxacin",0.348721986001856,0.167491087293764,FALSE
+"H358","Pearson.est","BCL inhibitor",0.5106,1.35,0.15,206,0.459,"HA14.1, TW.37, ABT.737, venetoclax",0.823908740944319,0.338187314462739,FALSE
+"H358","Pearson.est","Bcr.Abl kinase inhibitor",0.5405,1.43,0.105,414,0.52,"GZD824, metatinib, flumatinib, imatinib, tozasertib, nilotinib",0.978810700930062,0.283996656365201,FALSE
+"H358","Pearson.est","benzodiazepine receptor agonist",-0.36214,-1.04,0.402,902,0.546,"zaleplon, temazepam, CGS.20625, nefiracetam, gamma.aminobutyric.acid",0.39577394691553,0.262807357295263,FALSE
+"H358","Pearson.est","calcium channel blocker",0.4579,1.23,0.214,536,0.468,"SKF.96365, mibefradil, SR.33805, tetrandrine, pranidipine, carboxyamidotriazole, penfluridol, efonidipine.monoethanolate",0.669586226650809,0.329754146925876,FALSE
+"H358","Pearson.est","CC chemokine receptor antagonist",0.29196,0.778,0.72,395,0.801,"RS.504393, ZK811752, SB.225002",0.142667503568732,0.0963674839157623,FALSE
+"H358","Pearson.est","CDK inhibitor",0.49328,1.3,0.173,315,0.406,"kenpaullone, AZD5438, BMS.387032, alvocidib, TG.02, BMS.265246, indisulam, AT.7519, aminopurvalanol.a, P276.00, dinaciclib",0.761953896871205,0.391473966422806,FALSE
+"H358","Pearson.est","CHK inhibitor",0.36529,0.968,0.492,238,0.669,"PF.477736, CHIR.124, AZD7762",0.30803489723264,0.174573882232177,FALSE
+"H358","Pearson.est","cyclooxygenase inhibitor",0.30963,0.816,0.671,305,0.806,"piroxicam, amfenac, acetylsalicylsalicylic.acid, curcumin, tryptanthrin",0.173277479831008,0.0936649581949093,FALSE
+"H358","Pearson.est","cytochrome P450 inhibitor",-0.71831,-2.03,0.0141,1038,0.0716,"metyrapone, PF.4981517, eplerenone, morin",1.85078088734462,1.14508697769214,TRUE
+"H358","Pearson.est","DNA alkylating agent",-0.29116,-0.827,0.648,1088,0.769,"carboplatin, ifosfamide, dacarbazine, cisplatin",0.188424994129407,0.114073660198569,FALSE
+"H358","Pearson.est","DNA inhibitor",0.32207,0.859,0.632,330,0.782,"melphalan, chlorambucil, pibenzimol, valrubicin, oxaliplatin, primaquine",0.199282921717615,0.106793246940152,FALSE
+"H358","Pearson.est","DNA methyltransferase inhibitor",0.44101,1.16,0.293,611,0.532,"disulfiram, fdcyd, decitabine, azacitidine",0.533132379645891,0.274088367704952,FALSE
+"H358","Pearson.est","DNA polymerase inhibitor",-0.42939,-1.23,0.214,526,0.425,"trifluridine, menadione, cidofovir, foscarnet, cephalomannine, idoxuridine",0.669586226650809,0.371611069949688,FALSE
+"H358","Pearson.est","DNA synthesis inhibitor",-0.30809,-0.872,0.603,939,0.763,"azodicarbonamide, artemisinin, artesunate, cisplatin, capecitabine",0.219682687859849,0.11747546204512,FALSE
+"H358","Pearson.est","dopamine receptor antagonist",-0.46175,-1.34,0.15,1179,0.394,"ziprasidone, oxiperomide, amisulpride, domperidone",0.823908740944319,0.404503778174426,FALSE
+"H358","Pearson.est","estrogen receptor agonist",0.49608,1.32,0.153,530,0.45,"estradiol, equol, PPT, estrone",0.815308569182401,0.346787486224656,FALSE
+"H358","Pearson.est","FGFR inhibitor",-0.24528,-0.677,0.857,983,0.888,"PD.173074, dovitinib, AZD4547",0.0670191780768018,0.051587034221399,FALSE
+"H358","Pearson.est","FLT3 inhibitor",0.52278,1.38,0.128,358,0.476,"lestaurtinib, GTP.14564, TG.02, quizartinib, ENMD.2076, tyrphostin.AG.1296, midostaurin, KW.2449, tozasertib, pacritinib, sunitinib",0.892790030352132,0.322393047279507,FALSE
+"H358","Pearson.est","glucocorticoid receptor agonist",-0.38682,-1.07,0.363,959,0.53,"triamcinolone, fluocinolone.acetonide, prednisolone.hemisuccinate, desonide, deflazacort, fludroxycortide",0.440093374963888,0.275724130399211,FALSE
+"H358","Pearson.est","glutamate receptor antagonist",-0.47351,-1.36,0.139,1084,0.462,"CPP, SIB.1757, kynurenic.acid, JNJ.16259685, felbamate",0.856985199745905,0.335358024443874,FALSE
+"H358","Pearson.est","glycogen synthase kinase inhibitor",0.59237,1.58,0.0655,444,0.582,"kenpaullone, LY2090314, CHIR.98014, CHIR.99021, AZD2858, GSK.3.inhibitor.IX",1.18375870000822,0.235077015350112,FALSE
+"H358","Pearson.est","growth factor receptor inhibitor",0.40266,1.07,0.371,63,0.61,"lestaurtinib, danusertib",0.430626090384954,0.214670164989233,FALSE
+"H358","Pearson.est","HDAC inhibitor",0.51166,1.35,0.154,295,0.459,"M.344, dacinostat, chidamide, entinostat, SB.939, romidepsin, PCI.24781, givinostat, scriptaid, AR.42, ACY.1215",0.812479279163537,0.338187314462739,FALSE
+"H358","Pearson.est","histamine receptor antagonist",0.19531,0.521,0.964,5,0.97,"ICI.162846",0.0159229660971692,0.0132282657337552,FALSE
+"H358","Pearson.est","HSP inhibitor",0.42928,1.11,0.326,164,0.59,"XL888, PU.H71, NMS.E973, alvespimycin, SNX.5422",0.486782399932061,0.229147988357856,FALSE
+"H358","Pearson.est","JAK inhibitor",0.41605,1.1,0.323,371,0.582,"lestaurtinib, PRT062070, TG.02, TG.101209, tozasertib, pacritinib, WHI.P154, AT.9283",0.490797477668897,0.235077015350112,FALSE
+"H358","Pearson.est","KIT inhibitor",0.30449,0.804,0.677,358,0.802,"OSI.930, KI.8751, pazopanib, midostaurin, imatinib, telatinib, sunitinib",0.169411331314856,0.0958256317158365,FALSE
+"H358","Pearson.est","MEK inhibitor",-0.5586,-1.61,0.0556,932,0.38,"PD.0325901, PD.98059, selumetinib, Ro.4987655, AZD8330, PD.318088, TAK.733, PD.198306, trametinib, PD.184352, cobimetinib, AS.703026",1.25492520841794,0.42021640338319,FALSE
+"H358","Pearson.est","MET inhibitor",-0.42221,-1.22,0.231,886,0.379,"PHA.665752, INC.280, PF.04217903, NVP.BVU972",0.636388020107856,0.421360790031928,FALSE
+"H358","Pearson.est","microtubule inhibitor",0.36726,0.972,0.475,153,0.684,"cabazitaxel, D.64131",0.323306390375133,0.164943898279884,FALSE
+"H358","Pearson.est","mTOR inhibitor",0.49742,1.31,0.15,340,0.414,"WAY.600, PF.05212384, torin.2, ku.0063794, XL388, OSI.027, torin.1, WYE.125132, AZD8055, PF.04691502, deforolimus, PKI.179, WYE.354, sirolimus, MLN0128",0.823908740944319,0.382999658879101,FALSE
+"H358","Pearson.est","NFkB pathway inhibitor",0.5574,1.45,0.0895,321,0.535,"parthenolide, EVP4593, curcumin, betulinic.acid, bindarit, BAY.11.7085",1.04817696468409,0.271646217978772,FALSE
+"H358","Pearson.est","opioid receptor agonist",-0.50326,-1.47,0.113,828,0.505,"BW.180C, ADL5859, trimebutine, salvinorin.a",0.94692155651658,0.296708621881339,FALSE
+"H358","Pearson.est","p38 MAPK inhibitor",-0.47794,-1.34,0.157,1020,0.394,"TAK.715, SB.242235",0.804100347590766,0.404503778174426,FALSE
+"H358","Pearson.est","PARP inhibitor",0.52978,1.4,0.109,382,0.479,"PJ.34, talazoparib, olaparib, niraparib",0.962573502059376,0.319664486585437,FALSE
+"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.24139,0.649,0.881,358,0.898,"axitinib, KI.8751, crenolanib, pazopanib, CP.673451, imatinib, telatinib, sunitinib",0.0550240915879521,0.0467236633326956,FALSE
+"H358","Pearson.est","phosphatase inhibitor",0.55321,1.51,0.0744,402,0.656,"CID.5458317, sodium.stibogluconate, BVT.948, alexidine",1.12842706445412,0.18309616062434,FALSE
+"H358","Pearson.est","phosphodiesterase inhibitor",-0.42031,-1.22,0.232,955,0.379,"EMD.53998, trequinsin, avanafil, enoximone",0.6345120151091,0.421360790031928,FALSE
+"H358","Pearson.est","PI3K inhibitor",0.3225,0.855,0.61,486,0.766,"PIK.75, PF.05212384, CUDC.907, PF.04691502, PKI.179, CH5132799, PI3K.IN.2, NVP.BEZ235, AZD6482, BGT226, PI.103, YM.201636, TG.100713, ZSTK.474",0.214670164989233,0.115771230367396,FALSE
+"H358","Pearson.est","PLK inhibitor",0.32735,0.863,0.613,830,0.799,"rigosertib, volasertib, HMN.214, BI.2536, GSK461364, GW.843682X",0.212539525481585,0.0974532206860086,FALSE
+"H358","Pearson.est","progesterone receptor agonist",0.385,1.03,0.42,173,0.633,"melengestrol.acetate, dienogest",0.3767507096021,0.198596289982645,FALSE
+"H358","Pearson.est","proteasome inhibitor",0.50376,1.31,0.192,317,0.414,"MG.132, oprozomib, ONX.0914, delanzomib",0.71669877129645,0.382999658879101,FALSE
+"H358","Pearson.est","protein synthesis inhibitor",0.4845,1.29,0.19,323,0.399,"florfenicol, thiostrepton, methacycline, tedizolid.phosphate, mercaptopurine, anguidine, harringtonine, cycloheximide, homoharringtonine",0.721246399047171,0.399027104313252,FALSE
+"H358","Pearson.est","protein tyrosine kinase inhibitor",0.57945,1.58,0.0524,362,0.582,"BMS.599626, PP.121, tyrphostin.A9, AV.412",1.28066871301627,0.235077015350112,FALSE
+"H358","Pearson.est","RAF inhibitor",0.27149,0.723,0.772,276,0.855,"SB.590885, CEP.32496, RAF265",0.112382699664264,0.0680338852718274,FALSE
+"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.27837,-0.799,0.674,341,0.781,"cabozantinib, sunitinib, regorafenib, apatinib, sorafenib, vandetanib",0.17134010346468,0.1073489661227,FALSE
+"H358","Pearson.est","retinoid receptor agonist",0.63918,1.7,0.0271,448,0.585,"CD.437, tamibarotene, adapalene, LE.135, bexarotene, fenretinide",1.56703070912559,0.23284413391782,FALSE
+"H358","Pearson.est","ribonucleotide reductase inhibitor",0.32452,0.868,0.599,303,0.815,"triapine, clofarabine, fludarabine.phosphate, LY2334737",0.222573177610689,0.0888423912600234,FALSE
+"H358","Pearson.est","serotonin receptor antagonist",-0.21244,-0.619,0.918,906,0.914,"SB.216641, lurasidone, SB.200646, ziprasidone",0.0371573187987575,0.0390538042661686,FALSE
+"H358","Pearson.est","sodium channel blocker",-0.26149,-0.733,0.762,1115,0.849,"butamben, oxcarbazepine",0.1180450286604,0.0710923097560473,FALSE
+"H358","Pearson.est","src inhibitor",-0.35145,-1.02,0.399,891,0.55,"ZM.306416, masitinib, dasatinib, saracatinib",0.399027104313252,0.259637310505756,FALSE
+"H358","Pearson.est","TGF beta receptor inhibitor",-0.45111,-1.3,0.168,857,0.372,"SB.525334, repsox, SB.431542, D.4476, LY2109761",0.774690718274137,0.429457060118102,FALSE
+"H358","Pearson.est","thymidylate synthase inhibitor",-0.47438,-1.3,0.158,1131,0.372,"carmofur, capecitabine",0.801342913045577,0.429457060118102,FALSE
+"H358","Pearson.est","topoisomerase inhibitor",0.54248,1.45,0.13,386,0.535,"doxorubicin, exatecan.mesylate, voreloxin, nemorubicin, irinotecan, genz.644282, valrubicin, etoposide, beta.lapachone, etoposide.phosphate, teniposide, topotecan",0.886056647693163,0.271646217978772,FALSE
+"H358","Pearson.est","tubulin polymerization inhibitor",0.52489,1.41,0.117,208,0.506,"taltobulin, albendazole, parbendazole, KX2.391, vinorelbine, combretastatin.A.4, paclitaxel, docetaxel",0.931814138253838,0.295849483160201,FALSE
+"H358","Pearson.est","tyrosine kinase inhibitor",0.43693,1.18,0.274,362,0.522,"UNC2250, BMS.599626, GTP.14564, PP.121, tyrphostin.A9, aminopurvalanol.a, tivantinib, cabozantinib, sunitinib, AV.412",0.562249437179612,0.282329496997738,FALSE
+"H358","Pearson.est","VEGFR inhibitor",0.25216,0.68,0.846,358,0.886,"OSI.930, axitinib, KI.8751, lucitanib, ENMD.2076, AEE788, pazopanib, RAF265, semaxanib, telatinib, cabozantinib, sunitinib",0.0726296369609765,0.0525662781129492,FALSE
+"A549","Pearson.est","EGFR inhibitor",0.61182,1.79,0.0328,332,0.407,"erlotinib, vandetanib, pelitinib, gefitinib, GW.583340, afatinib, canertinib, PD.168393, icotinib, XL.647, poziotinib, neratinib, lapatinib, BMS.690514, osimertinib, BMS.599626, dacomitinib, TAK.285, AZD8931, CNX.2006, BIBX.1382, AST.1306, WZ8040, rociletinib, CP.724714, OSI.420, tyrphostin.AG.1478, BIBU.1361, brigatinib, WZ.3146",1.48412615628832,0.39040559077478,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",0.43276,1.26,0.217,199,0.707,"ZM.306416, bosutinib, dasatinib, GZD824, ponatinib",0.66354026615147,0.150580586203101,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",-0.46893,-1.31,0.182,1076,0.552,"pilocarpine, nefiracetam, oxiracetam, nicotine",0.739928612014925,0.258060922270801,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",-0.59188,-1.64,0.0475,970,0.346,"diphemanil, darifenacin, dicycloverine, iododexetimide",1.32330639037513,0.460923901207223,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.32125,0.926,0.507,294,0.895,"CGS.15943, SCH.58261",0.294992040666664,0.048176964684088,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",-0.32274,-0.925,0.531,1138,0.805,"ritodrine, epinephrine, isoxsuprine, isoetharine, xylazine, methyldopa",0.274905478918531,0.0942041196321315,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",-0.17849,-0.515,0.982,798,0.998,"naftidrofuryl, practolol, atenolol...., pindolol, oxprenolol, metoprolol, vincamine, idazoxan, levobunolol",0.00788851221305034,0.000869458712628891,FALSE
+"A549","Pearson.est","AKT inhibitor",0.28799,0.804,0.669,516,0.875,"ONC201, CCT128930, AT7867, uprosertib, GSK2110183, GDC.0068",0.174573882232177,0.0579919469776868,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.49903,1.44,0.108,363,0.567,"AP26113, CEP.37440, crizotinib, NVP.TAE684, brigatinib, AZD3463, DMH1",0.96657624451305,0.246416941107093,FALSE
+"A549","Pearson.est","androgen receptor antagonist",-0.36129,-1.03,0.4,949,0.805,"bicalutamide, flutamide, nilutamide",0.397940008672038,0.0942041196321315,FALSE
+"A549","Pearson.est","AP inhibitor",-0.6771,-1.97,0.00753,1019,0.0907,"LCL.161, idronoxil, GDC.0152, tanshinone.i, embelin",2.1232050237993,1.0423927129399,TRUE
+"A549","Pearson.est","ATPase inhibitor",-0.51397,-1.45,0.114,1064,0.472,"omeprazole, digoxin, rabeprazole, ouabain, blebbistatin...., digitoxigenin, digitoxin",0.943095148663527,0.326058001365912,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",0.42892,1.25,0.2,414,0.633,"AMG900, CCT129202, hesperadin, GSK1070916, alisertib, barasertib.HQPA, PHA.680632, danusertib, CCT137690, TAK.901, tozasertib, ENMD.2076, SNS.314, CYC116",0.698970004336019,0.198596289982645,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44521,-1.26,0.204,1289,0.593,"tilmicosin, azithromycin, dirithromycin",0.690369832574101,0.226945306635737,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.32131,-0.908,0.539,1136,0.768,"trovafloxacin, sarafloxacin, lomefloxacin",0.268411234813261,0.114638779968488,FALSE
+"A549","Pearson.est","BCL inhibitor",0.22454,0.641,0.892,287,0.939,"venetoclax, obatoclax",0.0496351456238769,0.0273344077338891,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.44096,1.28,0.202,308,0.717,"bosutinib, dasatinib, GZD824, ponatinib, tozasertib",0.694648630553376,0.1444808443322,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",-0.32882,-0.922,0.522,753,0.775,"ivermectin, CL.218872, zaleplon, lorazepam, temazepam, indiplon, bentazepam, nefiracetam, ZK.93423, CGS.20625",0.282329496997738,0.11069829749369,FALSE
+"A549","Pearson.est","bromodomain inhibitor",0.42601,1.25,0.21,370,0.633,"JQ1...., OTX015, I.BET.762, I.BET151",0.677780705266081,0.198596289982645,FALSE
+"A549","Pearson.est","calcium channel blocker",-0.26868,-0.762,0.69,1298,0.886,"cinnarazine, pranidipine",0.161150909262745,0.0525662781129492,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",0.52559,1.52,0.0809,36,0.64,"SB.225002, ZK811752",1.09205147838773,0.193820026016113,FALSE
+"A549","Pearson.est","CDK inhibitor",0.34615,0.983,0.46,320,0.881,"palbociclib, AT.7519, indisulam, aminopurvalanol.a, abemaciclib, alvocidib, PHA.848125, PHA.793887, ribociclib",0.337242168318426,0.0550240915879521,FALSE
+"A549","Pearson.est","CHK inhibitor",-0.8002,-2.28,0,1161,0.0221,"CHIR.124, AZD7762, SB.218078, PF.477736, LY2606368, SCH.900776",Inf,1.65560772631489,TRUE
+"A549","Pearson.est","cyclooxygenase inhibitor",-0.32578,-0.935,0.518,1302,0.823,"tepoxalin, amfenac, metoxibutropate, ketoprofen, AM.404",0.285670240254767,0.0846001647877302,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",0.3982,1.16,0.258,496,0.733,"cobicistat, morin, eplerenone, PF.4981517",0.58838029403677,0.134896025358872,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.29449,-0.837,0.6,1115,0.86,"cisplatin, dianhydrogalactitol, carboplatin, ifosfamide, temozolomide, cyclophosphamide",0.221848749616356,0.0655015487564323,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.46055,-1.31,0.18,1156,0.552,"chlorambucil, carboplatin, tirapazamine, teroxirone, busulfan, metronidazole, pibenzimol",0.744727494896694,0.258060922270801,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.35624,1.04,0.361,125,0.871,"azacitidine, fdcyd",0.442492798094342,0.0599818449923368,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",0.31349,0.92,0.53,447,0.874,"adefovir.dipivoxil, cephalomannine, trifluridine, cidofovir, menadione",0.275724130399211,0.058488567365597,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.36211,-1.02,0.423,1243,0.781,"CB.10.277, artemisinin, azodicarbonamide, nelarabine",0.373659632624958,0.1073489661227,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",0.25905,0.756,0.714,339,0.881,"remoxipride, piperacetazine, ziprasidone, oxiperomide, clebopride, domperidone",0.146301788223826,0.0550240915879521,FALSE
+"A549","Pearson.est","estrogen receptor agonist",0.2094,0.598,0.903,1118,0.939,"erteberel, levonorgestrel, equol, estradiol.cypionate, ethinyl.estradiol, PPT, estradiol, estrone",0.0443122496864942,0.0273344077338891,FALSE
+"A549","Pearson.est","FGFR inhibitor",-0.22505,-0.641,0.87,1061,0.991,"MK.2461, lucitanib, orantinib",0.0604807473813815,0.00392634551472468,FALSE
+"A549","Pearson.est","FLT3 inhibitor",-0.22547,-0.64,0.872,1067,0.96,"tandutinib, KW.2449, gilteritinib, lestaurtinib, sunitinib",0.0594835150674328,0.0177287669604316,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",0.4962,1.39,0.134,456,0.546,"ciclesonide, clobetasol.propionate, methylprednisolone, triamcinolone.acetonide, halobetasol.propionate, deflazacort, prednisolone.hemisuccinate, betamethasone, fludroxycortide, beclomethasone.dipropionate, prednisolone.acetate, flumethasone, triamcinolone, flumethasone.pivalate, dexamethasone.acetate, rimexolone",0.872895201635192,0.262807357295263,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.26345,0.767,0.701,444,0.888,"CPP, SIB.1757, MTPG, diazooxonorleucine, felbamate, latrepirdine",0.154281982033341,0.051587034221399,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",0.23664,0.7,0.813,1080,0.936,"TWS.119, CHIR.99021, tideglusib, AZD2858, LY2090314, kenpaullone, CHIR.98014, GSK.3.inhibitor.IX, indirubin",0.0899094544059319,0.0287241512618947,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",0.52532,1.51,0.0921,347,0.57,"GSK1904529A, GSK1838705A, danusertib, PHA.848125, AZD3463",1.03574036980315,0.244125144327509,FALSE
+"A549","Pearson.est","HDAC inhibitor",0.26512,0.769,0.752,519,0.909,"belinostat, panobinostat, pyroxamide, resminostat, JNJ.26481585, scriptaid, givinostat, AR.42, entinostat, NSC.3852, vorinostat, nexturastat.a, trichostatin.a, R306465, PCI.24781",0.123782159408358,0.0414361167780325,FALSE
+"A549","Pearson.est","histamine receptor antagonist",-0.32675,-0.945,0.503,1092,0.845,"nizatidine, epinastine, cyproheptadine, famotidine, ICI.162846, lafutidine, tecastemizole",0.298432014944073,0.0731432910503077,FALSE
+"A549","Pearson.est","HMGCR inhibitor",-0.79618,-2.24,0,1165,0.0176,"mevastatin, atorvastatin, simvastatin, fluvastatin, pitavastatin",Inf,1.75448733218585,TRUE
+"A549","Pearson.est","HSP inhibitor",-0.18372,-0.523,0.965,954,1,"guanidine, XL888, SNX.2112, NMS.E973",0.0154726866562074,0,FALSE
+"A549","Pearson.est","JAK inhibitor",0.21633,0.633,0.864,333,0.925,"atiprimod, ruxolitinib, pacritinib, tozasertib, WHI.P154, filgotinib",0.0634862575211067,0.0338582672609674,FALSE
+"A549","Pearson.est","KIT inhibitor",0.28792,0.82,0.641,315,0.873,"dasatinib, lenvatinib, vatalanib, midostaurin, motesanib, regorafenib",0.193141970481183,0.0589857562944303,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.62931,-1.79,0.0164,1219,0.203,"AMG.232, CGM097, serdemetan",1.7851561519523,0.692503962086787,TRUE
+"A549","Pearson.est","MEK inhibitor",0.55728,1.61,0.0589,281,0.543,"selumetinib, AZD8330, cobimetinib, AS.703026, refametinib, Ro.4987655, trametinib, PD.0325901, TAK.733, PD.318088, arctigenin, U.0126",1.2298847052129,0.265200170411153,FALSE
+"A549","Pearson.est","MET inhibitor",0.36574,1.06,0.374,383,0.869,"NVP.BVU972, PHA.665752, LY2801653",0.42712839779952,0.0609802235513335,FALSE
+"A549","Pearson.est","microtubule inhibitor",0.24048,0.68,0.83,30,0.938,"triclabendazole",0.0809219076239261,0.0277971616209356,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.34671,-0.986,0.468,952,0.807,"palomid.529, MLN0128, deforolimus, PP242, OSI.027, torin.1, WYE.125132, torin.2, sirolimus, LY3023414, ku.0063794",0.329754146925876,0.0931264652779296,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",0.29381,0.839,0.638,266,0.919,"tyloxapol, IKK.2.inhibitor.V, bortezomib, bindarit",0.195179321278838,0.0366844886138887,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.27715,-0.769,0.72,1150,0.906,"ADL5859, BW.180C",0.142667503568732,0.0428718023231869,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",-0.26811,-0.761,0.727,1215,0.857,"SB.242235, skepinone.l",0.138465589140962,0.0670191780768018,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.39874,-1.14,0.295,1348,0.725,"PJ.34, AG.14361",0.530177984021837,0.139661993429006,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.28728,0.832,0.627,315,0.903,"axitinib, dasatinib, lenvatinib, linifanib, ponatinib, vatalanib, motesanib, regorafenib",0.202732459169284,0.0443122496864942,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.28111,-0.795,0.694,1157,0.898,"CID.5458317, BVT.948, bis.maltolato.oxovanadium.IV.",0.158640529545145,0.0467236633326956,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",0.30735,0.869,0.603,151,0.95,"cilostamide, papaverine",0.219682687859849,0.0222763947111523,FALSE
+"A549","Pearson.est","PI3K inhibitor",0.1686,0.497,0.98,215,0.977,"PI.828, alpelisib, CH5132799, TG.100713",0.00877392430750515,0.0101054362812269,FALSE
+"A549","Pearson.est","PLK inhibitor",0.63238,1.8,0.0234,413,0.58,"GSK461364, volasertib, NMS.1286937, BI.2536",1.63078414258986,0.236572006437063,FALSE
+"A549","Pearson.est","potassium channel blocker",-0.5156,-1.48,0.0689,1027,0.481,"mepivacaine, ibutilide, meglitinide, dofetilide",1.16178077809237,0.317854923626168,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.34588,1.03,0.392,439,0.851,"ciprofibrate, oleoylethanolamide, clofibrate",0.406713932979543,0.0700704399154121,FALSE
+"A549","Pearson.est","progesterone receptor agonist",-0.52624,-1.54,0.0705,1125,0.445,"norethindrone.acetate, melengestrol.acetate, norgestrel, danazol",1.1518108830086,0.351639989019068,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.33333,0.971,0.498,944,0.869,"bortezomib, ONX.0914, carfilzomib, oprozomib, delanzomib, MG.132, ixazomib.citrate, ixazomib",0.302770657240282,0.0609802235513335,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.39897,-1.13,0.304,1105,0.695,"cycloheximide, thiostrepton, bruceantin, chloramphenicol.palmitate, mercaptopurine, azomycin..2.nitroimidazole.",0.517126416391246,0.158015195409886,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",0.42096,1.22,0.213,271,0.652,"NVP.TAE226, BMS.599626, mubritinib, CP.724714",0.671620396561262,0.18575240426808,FALSE
+"A549","Pearson.est","RAF inhibitor",0.30033,0.867,0.592,315,0.89,"CEP.32496, TAK.632, AZ.628, regorafenib",0.22767829327708,0.0506099933550872,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.44491,-1.25,0.209,1350,0.565,"apatinib, sunitinib",0.679853713888946,0.247951552180562,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.68364,1.97,0.0207,279,0.425,"CD.437, bexarotene, tamibarotene, fenretinide, AM.580, adapalene",1.68402965454308,0.371611069949688,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.36866,-1.05,0.383,1323,0.812,"pentostatin, cytarabine",0.416801226031377,0.0904439707588247,FALSE
+"A549","Pearson.est","serotonin receptor antagonist",-0.14297,-0.395,0.996,841,0.997,"sertindole, lurasidone, RS.16566, tropisetron, SB.200646",0.00174066157630127,0.00130484168834428,FALSE
+"A549","Pearson.est","sodium channel blocker",0.30685,0.867,0.599,157,0.89,"brivaracetam, ajmaline, benzethonium",0.222573177610689,0.0506099933550872,FALSE
+"A549","Pearson.est","src inhibitor",0.48787,1.39,0.14,136,0.546,"saracatinib, ZM.306416, bosutinib, dasatinib",0.853871964321762,0.262807357295263,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",0.29425,0.825,0.633,263,0.89,"sulconazole, chlormidazole",0.198596289982645,0.0506099933550872,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",-0.48438,-1.37,0.151,1137,0.555,"LY2109761, adaprev, D.4476",0.821023052706831,0.255707016877324,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",0.51961,1.47,0.11,415,0.568,"carmofur, raltitrexed, capecitabine, trifluridine, doxifluridine",0.958607314841775,0.245651664288981,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",0.23069,0.671,0.844,62,0.927,"dexrazoxane, daunorubicin, epirubicin",0.073657553374345,0.0329202658555029,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",0.35216,0.997,0.422,328,0.887,"mebendazole, albendazole, paclitaxel, indibulin, epothilone.b, docetaxel, plinabulin, parbendazole, vincristine",0.374687549038326,0.0520763801682736,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",0.39875,1.15,0.279,315,0.711,"NVP.TAE226, vandetanib, tyrphostin.AG.99, BMS.599626, dasatinib, aminopurvalanol.a, mubritinib, tivantinib, AMG.208, CP.724714, regorafenib",0.554395796726402,0.148130399270234,FALSE
+"A549","Pearson.est","VEGFR inhibitor",0.32981,0.963,0.489,432,0.85,"vandetanib, tivozanib, ZM.306416, XL.647, axitinib, BMS.690514, golvatinib, lenvatinib, linifanib, vatalanib, motesanib, regorafenib, ENMD.2076, semaxanib, cediranib, AEE788, PD.173074",0.31069114087638,0.0705810742857073,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",0.58106,1.66,0.0593,351,0.557,"calcitriol, alfacalcidol, tacalcitol, paricalcitol, maxacalcitol",1.22694530663574,0.254144804826271,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",-0.20418,-0.594,0.922,1291,0.928,"PD.168393, XL.647, tyrphostin.AG.1478, gefitinib, vandetanib, ARRY.334543",0.0352690789463706,0.0324520237811379,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",0.26327,0.706,0.824,226,0.976,"bafetinib, KW.2449, tozasertib",0.0840727883028842,0.0105501823333082,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",0.40581,1.09,0.356,635,0.633,"methscopolamine, darifenacin, dicycloverine, hyoscyamine",0.448550002027125,0.198596289982645,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",-0.4358,-1.25,0.223,1108,0.51,"CGS.15943, theophylline, sulmazole",0.651695136951839,0.292429823902064,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",0.23336,0.608,0.904,116,0.966,"buphenine, metaraminol",0.0438315695246367,0.0150228735845067,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",-0.35669,-1.02,0.409,1253,0.669,"idazoxan, imiloxan, naftidrofuryl, atenolol...., practolol, carvedilol",0.388276691992658,0.174573882232177,FALSE
+"HCC15","Pearson.est","AKT inhibitor",0.60668,1.59,0.0349,194,0.34,"MK.2206, A.674563, triciribine, GSK2110183, AZD5363, GDC.0068",1.45717457304082,0.468521082957745,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.38019,0.999,0.454,441,0.759,"CEP.37440, AP26113, AZD3463, NVP.TAE684",0.342944147142896,0.11975822410452,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.67353,-1.92,0.0106,949,0.38,"enzalutamide, cyproterone.acetate, RU.58841, bicalutamide, flutamide, nilutamide",1.97469413473523,0.42021640338319,FALSE
+"HCC15","Pearson.est","antioxidant",-0.23419,-0.664,0.846,1285,0.936,"benfotiamine",0.0726296369609765,0.0287241512618947,FALSE
+"HCC15","Pearson.est","AP inhibitor",0.60547,1.61,0.0487,545,0.347,"birinapant, idronoxil, tanshinone.i, LCL.161, GDC.0152",1.31247103878537,0.459670525209126,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",0.43873,1.18,0.264,329,0.582,"thonzonium, oligomycin.a, ouabain, evodiamine, omeprazole, digoxin",0.578396073130169,0.235077015350112,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",0.67754,1.79,0.0142,360,0.195,"TAK.901, PHA.680632, hesperadin, AT.9283, barasertib, ZM.447439, danusertib, GSK1070916, barasertib.HQPA, CCT129202, KW.2449, tozasertib, SNS.314, AMG900, PF.03814735, alisertib, aurora.a.inhibitor.i, MK.8745, CYC116",1.84771165561694,0.709965388637482,TRUE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.26865,0.712,0.783,259,1,"tedizolid, radezolid",0.106238237942057,0,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",-0.48903,-1.43,0.111,1371,0.564,"finafloxacin, nadifloxacin",0.954677021213343,0.248720896016658,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.63651,1.69,0.0324,172,0.3,"ABT.737, navitoclax, obatoclax, TW.37",1.48945498979339,0.522878745280338,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.28125,-0.837,0.624,1247,0.794,"bosutinib, imatinib, dasatinib",0.204815410317576,0.100179497572904,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",-0.4481,-1.29,0.178,1328,0.504,"gamma.aminobutyric.acid, bentazepam, zaleplon",0.749579997691106,0.297569463554475,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.69007,1.84,0.0137,375,0.185,"JQ1...., bromosporine, PFI.1, OTX015",1.86327943284359,0.732828271596986,TRUE
+"HCC15","Pearson.est","calcium channel blocker",0.284,0.766,0.731,372,0.952,"mibefradil, SKF.96365, carboxyamidotriazole, tetrandrine",0.13608262304214,0.0213630516155257,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.29988,0.798,0.685,471,0.97,"navarixin, SB.225002, UNBS.5162, ZK811752",0.164309428507574,0.0132282657337552,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.51321,1.38,0.14,476,0.42,"BMS.387032, dinaciclib, JNJ.7706621, indisulam, TG.02, kenpaullone, NU6027, AZD5438, AT.7519, palbociclib, BMS.265246, R547, abemaciclib, ribociclib",0.853871964321762,0.3767507096021,FALSE
+"HCC15","Pearson.est","CHK inhibitor",0.23489,0.624,0.896,607,0.971,"SB.218078, CHIR.124, AZD7762, SCH.900776",0.0476919903378748,0.0127807700919951,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.22217,-0.645,0.895,1156,0.919,"phenylbutazone, tryptanthrin, acetylsalicylsalicylic.acid, aspirin, metoxibutropate, phenazone",0.048176964684088,0.0366844886138887,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",-0.60937,-1.73,0.0386,884,0.322,"morin, PF.4981517, clotrimazole, eplerenone, metyrapone",1.41341269532825,0.492144128304169,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",0.26352,0.692,0.828,416,0.974,"carmustine, melphalan, dianhydrogalactitol, mitomycin.c, estramustine, TH.302",0.0819696632151199,0.0114410431213845,FALSE
+"HCC15","Pearson.est","DNA inhibitor",0.44101,1.17,0.272,303,0.578,"chlorambucil, oxaliplatin, carmustine, melphalan, valrubicin, mechlorethamine",0.565431095965801,0.238072161579471,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.47532,1.25,0.212,450,0.529,"azacitidine, disulfiram, fdcyd, SGI.1027",0.673664139071249,0.276544327964814,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.24958,0.66,0.872,18,0.971,"cephalomannine",0.0594835150674328,0.0127807700919951,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",0.21621,0.571,0.941,382,0.976,"enocitabine, floxuridine, cyclocytidine, mitomycin.c",0.0264103765727431,0.0105501823333082,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",-0.44764,-1.29,0.197,1057,0.504,"amisulpride, lurasidone, clebopride, UH.232...., raclopride, piperacetazine, mesoridazine",0.705533773838407,0.297569463554475,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.47744,-1.38,0.127,1319,0.56,"estrone, estradiol.cypionate",0.896196279044043,0.2518119729938,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.6053,1.62,0.053,378,0.385,"erdafitinib, PD.173074, nintedanib, dovitinib, lucitanib, regorafenib",1.27572413039921,0.414539270491499,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.42469,1.11,0.33,511,0.618,"KW.2449, sorafenib, tozasertib, TG.02, TG.101348, quizartinib, dovitinib, pacritinib, ponatinib, lestaurtinib",0.481486060122112,0.209011524911184,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.54318,-1.58,0.0771,1063,0.419,"methylprednisolone, prednisolone.acetate, flumethasone, difluprednate, desonide, flumethasone.pivalate, fluticasone.propionate, beclomethasone.dipropionate, clobetasol.propionate, fluocinolone.acetonide, halcinonide, halobetasol.propionate, ciclesonide, dexamethasone.acetate",1.11294562194904,0.377785977033705,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",-0.41344,-1.18,0.254,1407,0.576,"tiletamine, MTPG",0.595166283380062,0.239577516576788,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.53294,1.43,0.105,373,0.392,"CHIR.99021, AZD2858, kenpaullone, LY2090314, TWS.119",0.978810700930062,0.406713932979543,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",0.54966,1.46,0.0782,511,0.425,"danusertib, GSK1904529A, AZD3463, GW.441756, lestaurtinib",1.10679324694015,0.371611069949688,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.45984,1.22,0.22,567,0.533,"PCI.24781, AR.42, givinostat, NSC.3852, tacedinaline, chidamide, entinostat, M.344, scriptaid, RGFP966, pyroxamide, panobinostat, dacinostat, romidepsin, trichostatin.a, JNJ.26481585, SB.939, vorinostat",0.657577319177794,0.273272790973428,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",-0.45702,-1.32,0.173,1056,0.589,"tecastemizole, cyproheptadine, terfenadine, cimetidine, epinastine, famotidine, ICI.162846, zolantidine, ranitidine",0.761953896871205,0.229884705212898,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",0.35433,0.941,0.526,528,0.799,"simvastatin, mevastatin, lovastatin, fluvastatin, atorvastatin",0.279014255846261,0.0974532206860086,FALSE
+"HCC15","Pearson.est","HSP inhibitor",0.20521,0.538,0.943,251,0.978,"VER.49009, XL888",0.0254883072626717,0.00966114521239857,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.41664,1.12,0.319,286,0.622,"AT.9283, TG.101209, CEP.33779, tozasertib, TG.02, TG.101348, AZ960",0.496209316942819,0.206209615309181,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.20567,0.529,0.95,418,0.964,"sorafenib, OSI.930, KI.8751, regorafenib, motesanib",0.0222763947111523,0.0159229660971692,FALSE
+"HCC15","Pearson.est","MDM inhibitor",0.73989,1.93,0.00458,153,0.131,"nutlin.3, idasanutlin, AMG.232, CGM097",2.33913452199613,0.882728704344236,TRUE
+"HCC15","Pearson.est","MEK inhibitor",-0.28163,-0.795,0.705,1179,0.827,"PD.318088, arctigenin, refametinib, Ro.4987655, AS.703026",0.151810883008601,0.0824944904474534,FALSE
+"HCC15","Pearson.est","MET inhibitor",0.29708,0.788,0.709,404,0.962,"PF.04217903, PHA.665752",0.149353764816933,0.0168249279621871,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.49469,1.3,0.18,310,0.512,"vinflunine, cytochalasin.b, D.64131, colchicine, triclabendazole",0.744727494896694,0.290730039024169,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",0.26169,0.691,0.83,243,0.954,"XL388, PI.103, WYE.125132, GSK2126458, PF.04691502, OSI.027",0.0809219076239261,0.0204516252959049,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.42719,1.16,0.276,736,0.574,"parthenolide...., curcumin, EVP4593, BAY.11.7082, Ro.106.9920, bortezomib, IKK.2.inhibitor.V, bindarit",0.559090917934782,0.241088107602027,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",0.24706,0.654,0.86,649,0.958,"ADL5859, trimebutine, salvinorin.a, cebranopadol",0.0655015487564323,0.0186344909214556,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",0.54367,1.43,0.122,297,0.392,"SB.242235, talmapimod, skepinone.l, SB.239063",0.913640169325252,0.406713932979543,FALSE
+"HCC15","Pearson.est","PARP inhibitor",0.58209,1.54,0.0673,596,0.39,"olaparib, talazoparib, niraparib, AG.14361, PJ.34, endo.IWR.1, AZD2461, E7449",1.17198493577602,0.408935392973501,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.26111,0.706,0.82,418,0.976,"sorafenib, nintedanib, KI.8751, dovitinib, SU014813, axitinib, linifanib, regorafenib, motesanib",0.0861861476162833,0.0105501823333082,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.33106,0.908,0.559,133,0.813,"sodium.stibogluconate, CID.5458317",0.252588192113577,0.0899094544059319,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",0.47247,1.25,0.216,192,0.529,"cilostamide, papaverine, YM.976",0.665546248849069,0.276544327964814,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",0.29144,0.773,0.742,477,0.964,"PI.103, CH5132799, GSK2126458, PF.04691502, buparlisib, taselisib, BGT226, alpelisib, voxtalisib, CUDC.907, ZSTK.474, GDC.0941, PI3K.IN.2",0.129596094720973,0.0159229660971692,FALSE
+"HCC15","Pearson.est","PLK inhibitor",-0.31377,-0.914,0.548,1150,0.78,"HMN.214, rigosertib",0.261219441515631,0.10790539730952,FALSE
+"HCC15","Pearson.est","potassium channel blocker",-0.34993,-1.02,0.398,1301,0.669,"mepivacaine, oleoylethanolamide",0.400116927926312,0.174573882232177,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.31027,-0.905,0.553,1116,0.753,"ciprofibrate, fenofibrate, oleoylethanolamide",0.257274868695302,0.123205023799299,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.30161,-0.849,0.596,935,0.815,"melengestrol.acetate, dienogest, levonorgestrel, norgestrel, danazol, norethindrone.acetate",0.224753740259764,0.0888423912600234,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.82848,2.21,0,164,0.00966,"ixazomib.citrate, delanzomib, MG.132, carfilzomib, oprozomib, ixazomib",Inf,2.01502287358451,TRUE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.37313,0.997,0.469,498,0.74,"methacycline, florfenicol, harringtonine, bruceantin, anguidine, tedizolid.phosphate, brefeldin.a, homoharringtonine",0.328827157284917,0.130768280269024,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.52595,1.38,0.125,341,0.42,"NVP.TAE226, mubritinib, tyrphostin.A9",0.903089986991944,0.3767507096021,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.50701,1.34,0.149,420,0.464,"TAK.632, CEP.32496, sorafenib, AZ.628, RAF265, regorafenib, LGX818",0.826813731587726,0.333482019445119,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",-0.24403,-0.695,0.834,1334,0.939,"vandetanib",0.0788339493622613,0.0273344077338891,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",0.54139,1.43,0.111,532,0.392,"AM.580, tamibarotene, bexarotene, fenretinide, CD.437",0.954677021213343,0.406713932979543,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.37092,0.999,0.449,603,0.759,"LY2334737, clofarabine, fludarabine, triapine, cladribine, pentostatin, gemcitabine, fludarabine.phosphate",0.347753658996677,0.11975822410452,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",0.34782,0.918,0.572,513,0.817,"SB.200646, pirenperone, ziprasidone, sertindole, SB.216641, SB.228357",0.242603971206976,0.0877779434675845,FALSE
+"HCC15","Pearson.est","sodium channel blocker",-0.34429,-0.99,0.413,1245,0.682,"oxcarbazepine, quinidine, mepivacaine, benzocaine",0.384049948343599,0.166215625343521,FALSE
+"HCC15","Pearson.est","src inhibitor",-0.36537,-1.1,0.347,1207,0.619,"saracatinib, bosutinib, PP.2, dasatinib",0.459670525209126,0.208309350979882,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",-0.39557,-1.15,0.279,1183,0.579,"posaconazole, terconazole, lanoconazole",0.554395796726402,0.237321436272564,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",-0.64729,-1.88,0.014,1269,0.242,"D.4476, repsox, LY2109761",1.85387196432176,0.616184634019569,TRUE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.57091,1.52,0.0797,436,0.384,"raltitrexed, carmofur, doxifluridine",1.09854167860389,0.415668775632469,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",0.56227,1.47,0.0978,411,0.443,"nemorubicin, mitoxantrone, topotecan, genz.644282, TAS.103, amsacrine, etoposide.phosphate, etoposide, epirubicin, idarubicin, voreloxin, valrubicin, doxorubicin, licochalcone.a, daunorubicin, teniposide, dexrazoxane, camptothecin",1.0096611452124,0.35359627377693,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.4848,1.29,0.196,405,0.506,"fenbendazole, vincristine, CYT.997, oxibendazole, vinorelbine, mebendazole, nocodazole, KX2.391, albendazole, parbendazole, indibulin, combretastatin.A.4, flubendazole, docetaxel, dolastatin.10, plinabulin, vindesine",0.707743928643524,0.295849483160201,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.31361,0.831,0.638,378,0.934,"bafetinib, UNC2250, sorafenib, NVP.TAE226, mubritinib, tyrphostin.A9, regorafenib",0.195179321278838,0.0296531237699066,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.46221,1.24,0.24,418,0.523,"foretinib, PD.173074, AEE788, sorafenib, OSI.930, golvatinib, MGCD.265, nintedanib, KI.8751, RAF265, dovitinib, SU014813, lucitanib, axitinib, tivozanib, linifanib, regorafenib, motesanib",0.619788758288394,0.281498311132726,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",0.37165,0.99,0.453,82,0.731,"ercalcitriol, alfacalcidol",0.343901797987168,0.13608262304214,FALSE
+"HCC44","Pearson.est","EGFR inhibitor",-0.12151,-0.378,1,281,0.999,"dovitinib, WZ.4002, PD.153035, AZD8931, poziotinib, tyrphostin.AG.1478, tucatinib, PD.168393, icotinib, osimertinib, erlotinib, CNX.2006, dacomitinib, afatinib, AEE788, brigatinib, WZ8040, pelitinib, BIBX.1382, neratinib, CP.724714, BIBU.1361, ARRY.334543, tyrphostin.AG.494, canertinib, gefitinib, XL.647, lapatinib, rociletinib, OSI.420, salvianolic.acid.B, FERb.033, BMS.690514",0,0.000434511774017692,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",0.38209,1.04,0.414,333,0.587,"GZD824, KW.2449, tozasertib, bafetinib, flumatinib, ZM.306416",0.382999658879101,0.231361898752386,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",0.34917,0.974,0.477,22,0.618,"clenbuterol, midodrine",0.321481620959886,0.209011524911184,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",0.363,1.03,0.403,445,0.558,"oxprenolol, dronedarone, practolol, naftidrofuryl, vincamine, metoprolol, atipamezole, idazoxan",0.39469495385889,0.253365801062421,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.31927,-0.973,0.436,821,0.735,"AZD5363, triciribine, GDC.0068, ONC201, GSK2110183",0.360513510731414,0.133712660915805,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.32892,-1.04,0.378,1039,0.82,"DMH1, crizotinib",0.422508200162775,0.0861861476162833,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",-0.33154,-0.997,0.415,1064,0.791,"digoxin, digitoxigenin",0.381951903287907,0.101823516502323,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",0.52812,1.44,0.0836,411,0.416,"MLN.8054, KW.2449, danusertib, GSK1070916, tozasertib, CCT137690, aurora.a.inhibitor.i, PHA.680632, CCT129202",1.07779372256098,0.380906669373257,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34099,-1.07,0.34,1146,0.911,"azalomycin.b",0.468521082957745,0.0404816230270017,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",0.37504,1.04,0.408,55,0.587,"trovafloxacin",0.38933983691012,0.231361898752386,FALSE
+"HCC44","Pearson.est","BCL inhibitor",-0.29326,-0.914,0.535,976,0.762,"navitoclax, oridonin, venetoclax",0.271646217978772,0.1180450286604,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",0.29236,0.831,0.646,325,0.761,"GZD824, tozasertib, bafetinib, flumatinib",0.189767482004916,0.118615343229427,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.31893,-0.978,0.444,369,0.773,"ivermectin, zaleplon, ZK.93423, bentazepam, CGS.20625, indiplon, CL.218872, nefiracetam",0.35261702988538,0.111820506081675,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",-0.54679,-1.72,0.0316,870,0.525,"I.BET.762, bromosporine, JQ1...., OTX015",1.5003129173816,0.279840696594043,FALSE
+"HCC44","Pearson.est","calcium channel blocker",-0.34618,-1.09,0.346,861,1,"tetrandrine, mibefradil, pranidipine, penfluridol, SR.33805, fendiline",0.460923901207223,0,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",0.4306,1.18,0.282,531,0.541,"SB.225002, navarixin, MK.0812, ZK811752",0.549750891680639,0.266802734893431,FALSE
+"HCC44","Pearson.est","CDK inhibitor",0.39845,1.1,0.345,231,0.653,"aminopurvalanol.a, abemaciclib, PHA.848125, indisulam, ribociclib, PHA.793887, TG.02",0.462180904926726,0.185086818724926,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",0.49714,1.37,0.153,440,0.381,"metoxibutropate, FR.122047, piroxicam, ketoprofen, amfenac, meloxicam, suxibuzone, curcumin, pterostilbene",0.815308569182401,0.419075024324381,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",0.23995,0.676,0.859,81,0.922,"mitomycin.c, satraplatin",0.0660068361687577,0.0352690789463706,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.23632,-0.719,0.795,882,0.825,"busulfan, chlorambucil, bendamustine, teroxirone, mechlorethamine",0.0996328713435297,0.0835460514500749,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.34685,-1.06,0.352,1034,0.849,"trifluridine, cidofovir",0.453457336521869,0.0710923097560473,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",0.16431,0.456,0.99,201,0.987,"mitomycin.c, estramustine.phosphate",0.00436480540245009,0.00568284733036327,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",0.5042,1.42,0.105,124,0.367,"acetophenazine, piperacetazine, UH.232...., oxiperomide, lurasidone",0.978810700930062,0.435333935747911,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",0.51028,1.41,0.104,74,0.352,"estradiol, estrone",0.98296666070122,0.453457336521869,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",-0.24287,-0.776,0.763,281,0.885,"dovitinib, nintedanib, regorafenib, MK.2461, lucitanib, erdafitinib, AZD4547, lenvatinib",0.11747546204512,0.0530567293021746,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",0.39417,1.06,0.416,282,0.605,"sunitinib, KW.2449, sorafenib, tozasertib, TG.02, lestaurtinib, dovitinib",0.380906669373257,0.218244625347531,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",0.64499,1.79,0.0125,274,0.188,"deflazacort, triamcinolone, ciclesonide, fludroxycortide, fluorometholone, halobetasol.propionate, rimexolone, fluocinolone.acetonide, flumethasone.pivalate, halcinonide, clobetasol.propionate, flumethasone, difluprednate",1.90308998699194,0.72584215073632,TRUE
+"HCC44","Pearson.est","glutamate receptor antagonist",-0.24699,-0.756,0.776,967,0.88,"felbamate, CGP.37849",0.110138278741812,0.0555173278498314,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.35955,-1.11,0.298,416,1,"indirubin, GSK.3.inhibitor.IX, kenpaullone, LY2090314, CHIR.98014, TWS.119, tideglusib, AZD2858",0.525783735923745,0,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",-0.42036,-1.34,0.139,852,0.808,"tacedinaline, vorinostat, M.344, AR.42, chidamide, pyroxamide, entinostat, dacinostat, panobinostat, SB.939, romidepsin, resminostat",0.856985199745905,0.0925886392254138,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",0.20063,0.538,0.945,412,0.982,"epinastine, astemizole, ranitidine, levocetirizine, tiotidine, BF2.649",0.0245681914907371,0.00788851221305034,FALSE
+"HCC44","Pearson.est","HSP inhibitor",-0.7409,-2.31,0.00621,981,0.0458,"NMS.E973, NVP.AUY922, alvespimycin, ganetespib, tanespimycin, BIIB021, SNX.5422, VER.49009",2.20690839982342,1.33913452199613,TRUE
+"HCC44","Pearson.est","JAK inhibitor",0.23666,0.658,0.883,305,0.914,"tozasertib, TG.02, lestaurtinib, atiprimod, TG.101209",0.0540392964224314,0.0390538042661686,FALSE
+"HCC44","Pearson.est","KIT inhibitor",0.47037,1.31,0.174,102,0.444,"masitinib, KI.8751, sunitinib, sorafenib",0.7594507517174,0.35261702988538,FALSE
+"HCC44","Pearson.est","MEK inhibitor",0.42679,1.19,0.24,423,0.554,"trametinib, PD.198306, PD.318088, TAK.733, PD.0325901, cobimetinib, AZD8330, MEK162, AS.703026, nobiletin, arctigenin",0.619788758288394,0.25649023527157,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",0.4638,1.27,0.187,436,0.479,"colchicine, vinflunine, vinblastine, estramustine.phosphate, D.64131, cytochalasin.b, secnidazole, podophyllotoxin",0.728158393463501,0.319664486585437,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",-0.24972,-0.754,0.755,1022,0.845,"PI.103, deforolimus, GSK2126458, SB.2343, PP242",0.122053048370812,0.0731432910503077,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",-0.33076,-1.03,0.393,1046,0.78,"bindarit, Ro.106.9920, parthenolide",0.405607449624573,0.10790539730952,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",0.39018,1.07,0.384,191,0.643,"skepinone.l, CMPD.1",0.415668775632469,0.191789027075778,FALSE
+"HCC44","Pearson.est","PARP inhibitor",-0.37456,-1.14,0.282,886,1,"niraparib, olaparib, PJ.34, E7449, endo.IWR.1",0.549750891680639,0,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.39769,1.08,0.37,106,0.657,"masitinib, KI.8751, sunitinib, axitinib, sorafenib, crenolanib",0.431798275933005,0.182434630440219,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",0.5874,1.6,0.0561,277,0.289,"alexidine, CID.5458317, BVT.948, mycophenolic.acid, menadione",1.25103713874384,0.539102157243452,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",-0.52049,-1.6,0.0685,946,0.55,"enoximone, trequinsin, anagrelide, EMD.53998",1.16430942850757,0.259637310505756,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",-0.43984,-1.37,0.152,901,0.918,"taselisib, buparlisib, PF.05212384, TG100.115, idelalisib, CUDC.907, PI.103, TG.100713, CH5132799, GSK2126458, GDC.0941, SB.2343",0.818156412055227,0.0371573187987575,FALSE
+"HCC44","Pearson.est","PLK inhibitor",0.34188,0.962,0.476,372,0.614,"rigosertib, NMS.1286937, GSK461364",0.322393047279507,0.211831628858832,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",0.30424,0.839,0.642,205,0.774,"melengestrol.acetate, norgestrel",0.192464971931147,0.111259039317107,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",0.7695,2.16,0.00297,270,0.0228,"oprozomib, carfilzomib, ixazomib.citrate, ixazomib, bortezomib, ONX.0914",2.52724355068279,1.64206515299955,TRUE
+"HCC44","Pearson.est","protein synthesis inhibitor",0.59364,1.63,0.0379,297,0.295,"florfenicol, harringtonine, anguidine, bruceantin, chloramphenicol.palmitate, puromycin, tedizolid.phosphate, mercaptopurine, brefeldin.a, methacycline, cycloheximide, azomycin..2.nitroimidazole.",1.42136079003193,0.530177984021837,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.5126,1.42,0.108,347,0.367,"rheochrysidin, mubritinib, tyrphostin.A9",0.96657624451305,0.435333935747911,FALSE
+"HCC44","Pearson.est","RAF inhibitor",0.52678,1.45,0.0929,360,0.448,"vemurafenib, sorafenib, dabrafenib, RAF265, LGX818, CEP.32496, AZ.628",1.03198428600636,0.348721986001856,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",-0.28756,-0.893,0.529,333,0.723,"fenretinide, LE.135, adapalene, bexarotene, CD.437, AM.580, tamibarotene",0.276544327964814,0.140861702705469,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.29934,-0.942,0.495,895,0.751,"clofarabine, fludarabine, gemcitabine, fludarabine.phosphate, LY2334737",0.305394801066431,0.124360062995832,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",0.37048,1.03,0.426,409,0.558,"SB.228357, lurasidone, SB.200646, ziprasidone",0.370590400897281,0.253365801062421,FALSE
+"HCC44","Pearson.est","sodium channel blocker",0.37076,1.06,0.397,317,0.605,"quinidine, A.803467, triamterene, butamben, lappaconite",0.401209493236885,0.218244625347531,FALSE
+"HCC44","Pearson.est","src inhibitor",-0.30721,-0.912,0.526,892,0.726,"dasatinib, saracatinib, bosutinib, TG.100572",0.279014255846261,0.139063379299906,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",0.63974,1.8,0.0147,307,0.27,"ketoconazole, lanoconazole, terconazole, chlormidazole, sulconazole",1.83268266525182,0.568636235841013,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.239,-0.734,0.751,277,0.838,"carmofur, raltitrexed, ftorafur, capecitabine, doxifluridine, trifluridine",0.124360062995832,0.0767559813697235,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",0.44015,1.22,0.23,414,0.535,"beta.lapachone, valrubicin, irinotecan, dexrazoxane, etoposide.phosphate, camptothecin, TAS.103, teniposide, amonafide, daunorubicin, topotecan, etoposide",0.638272163982407,0.271646217978772,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",0.60467,1.66,0.0314,459,0.311,"albendazole, mebendazole, parbendazole, verubulin, vincristine, vinblastine, ABT.751, plinabulin, indibulin, vindesine, combretastatin.A.4, CYT.997, taltobulin, vinorelbine, flubendazole, docetaxel, dolastatin.10, paclitaxel, BNC105, epothilone.d, podophyllotoxin, nocodazole, oxibendazole",1.50307035192679,0.507239610973163,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",0.5393,1.53,0.0782,351,0.354,"sunitinib, apatinib, sorafenib, aminopurvalanol.a, rheochrysidin, cabozantinib, tivantinib, mubritinib, bafetinib, tyrphostin.A9, AMG.208",1.10679324694015,0.450996737974212,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",0.27644,0.786,0.715,399,0.802,"KI.8751, sunitinib, axitinib, sorafenib, RAF265, cabozantinib, dovitinib, nintedanib, ZM.306416, vatalanib, SU014813, golvatinib",0.145693958198919,0.0958256317158365,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",-0.33687,-1.07,0.354,894,0.911,"alfacalcidol, doxercalciferol, maxacalcitol",0.450996737974212,0.0404816230270017,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.53844,1.56,0.0822,350,0.221,"osimertinib, poziotinib, afatinib, tucatinib, dacomitinib, canertinib, tyrphostin.AG.494, AZD8931, pelitinib, erlotinib, ARRY.334543, BIBX.1382, CP.724714, PD.168393, neratinib, vandetanib, PD.153035, XL.647, BIBU.1361, WZ.4002, CNX.2006, gefitinib, TAK.285, BMS.690514, lapatinib",1.08512818245995,0.655607726314889,FALSE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.5501,-1.45,0.109,972,0.408,"metatinib, tozasertib, imatinib, flumatinib, nilotinib, KW.2449, GZD824",0.962573502059376,0.38933983691012,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",0.60468,1.73,0.0409,158,0.264,"SCH.58261, PSB.1115, istradefylline",1.38827669199266,0.578396073130169,FALSE
+"H1299","Pearson.est","adrenergic receptor agonist",0.545,1.56,0.0705,150,0.221,"lidamidine, A61603, isoetharine, ritodrine, norepinephrine, xylazine",1.1518108830086,0.655607726314889,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",0.55908,1.61,0.0426,229,0.331,"prazosin, naftidrofuryl, atenolol...., pindolol, propranolol, imiloxan",1.37059040089728,0.480172006224281,FALSE
+"H1299","Pearson.est","AKT inhibitor",-0.31407,-0.844,0.631,695,0.819,"GSK2110183, CCT128930, GDC.0068, uprosertib, AZD5363, triciribine, MK.2206, A.674563",0.199970640755866,0.0867160982395816,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.2079,0.595,0.949,1074,0.931,"SB.505124, GW.788388, AZD3463, DMH1, NVP.TAE684, CEP.37440, crizotinib, brigatinib, lorlatinib, alectinib, AP26113",0.0227337875727074,0.0310503190186574,FALSE
+"H1299","Pearson.est","antioxidant",0.69234,1.98,0.0114,369,0.157,"rutin, trolox, benfotiamine, taurine, chlorogenic.acid",1.94309514866353,0.804100347590766,TRUE
+"H1299","Pearson.est","AP inhibitor",-0.71722,-1.89,0.00657,1310,0.336,"birinapant, GDC.0152, LCL.161",2.18243463044022,0.473660722610156,FALSE
+"H1299","Pearson.est","ATPase inhibitor",-0.68567,-1.84,0.00939,1034,0.248,"blebbistatin...., NMS.873, digitoxigenin, ouabain, omeprazole, digitoxin",2.02733440773389,0.605548319173784,TRUE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.62085,-1.67,0.032,922,0.481,"MK.8745, GSK1070916, aurora.a.inhibitor.i, AT.9283, tozasertib, ENMD.2076, TAK.901, PHA.680632, barasertib, ZM.447439, MK.5108, KW.2449, CCT137690, danusertib, CCT129202, CYC116, AMG900, SNS.314, PF.03814735, barasertib.HQPA",1.49485002168009,0.317854923626168,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30271,-0.812,0.693,1316,0.849,"tedizolid",0.159266765388193,0.0710923097560473,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.49357,-1.33,0.157,995,0.362,"TW.37, oridonin, venetoclax, ABT.737, HA14.1",0.804100347590766,0.441291429466834,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.55374,-1.49,0.0845,972,0.47,"metatinib, tozasertib, imatinib, flumatinib, nilotinib, GZD824",1.07314329105031,0.327902142064283,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.40619,1.19,0.251,429,0.441,"gamma.aminobutyric.acid, eprinomectin, indiplon, zaleplon, temazepam, CL.218872, nefiracetam",0.600326278518962,0.355561410532161,FALSE
+"H1299","Pearson.est","calcium channel blocker",-0.57566,-1.51,0.0756,939,0.493,"efonidipine.monoethanolate, pranidipine, penfluridol, carboxyamidotriazole, SR.33805, tetrandrine, SKF.96365",1.12147820449879,0.30715308072277,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.37115,-0.987,0.456,1185,0.648,"RS.504393",0.341035157335565,0.188424994129407,FALSE
+"H1299","Pearson.est","CDK inhibitor",-0.46332,-1.23,0.227,924,0.433,"palbociclib, TG.02, dinaciclib, BMS.265246, aminopurvalanol.a, arcyriaflavin.a, AZD5438, alvocidib, PHA.793887, indisulam, kenpaullone, AT.7519, BMS.387032",0.643974142806877,0.363512103646635,FALSE
+"H1299","Pearson.est","CHK inhibitor",-0.52486,-1.38,0.132,997,0.427,"AZD7762, SB.218078, CHIR.124, PF.477736",0.87942606879415,0.369572124974976,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",-0.28511,-0.766,0.75,1112,0.875,"curcumin, piroxicam, aspirin, acetylsalicylsalicylic.acid, indoprofen, AM.404",0.1249387366083,0.0579919469776868,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",0.53703,1.53,0.0972,246,0.219,"eplerenone, morin, PF.4981517",1.01233373507373,0.659555885159882,FALSE
+"H1299","Pearson.est","DNA alkylating agent",-0.33262,-0.894,0.576,1018,0.784,"estramustine, TH.302, dianhydrogalactitol, melphalan, cyclophosphamide, mitomycin.c",0.239577516576788,0.105683937315562,FALSE
+"H1299","Pearson.est","DNA inhibitor",0.23899,0.672,0.845,213,0.962,"mechlorethamine, nimorazole, metronidazole, carboplatin, tirapazamine",0.0731432910503077,0.0168249279621871,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",-0.48309,-1.27,0.202,819,0.41,"disulfiram, decitabine, fdcyd",0.694648630553376,0.387216143280265,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",0.32615,0.916,0.516,914,0.674,"famciclovir, idoxuridine, cidofovir, foscarnet, cephalomannine, trifluridine, adefovir.dipivoxil",0.287350298372789,0.17134010346468,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",-0.2076,-0.548,0.942,1221,0.976,"mitomycin.c, altretamine",0.0259490972071227,0.0105501823333082,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",-0.27888,-0.752,0.743,1181,0.851,"isofloxythepin, acetophenazine, raclopride, piperacetazine",0.129011186239425,0.0700704399154121,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",0.44305,1.31,0.16,8,0.415,"levonorgestrel",0.795880017344075,0.381951903287907,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",0.62616,1.83,0.0187,131,0.22,"raloxifene, clomifene, danazol",1.7281583934635,0.657577319177794,TRUE
+"H1299","Pearson.est","FGFR inhibitor",-0.23053,-0.614,0.906,940,0.949,"nintedanib, orantinib, lucitanib",0.0428718023231869,0.0227337875727074,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.52513,-1.38,0.142,973,0.427,"TG.02, tozasertib, tyrphostin.AG.1296, TG.101348, ENMD.2076, GTP.14564, quizartinib, midostaurin, KW.2449, lestaurtinib",0.847711655616944,0.369572124974976,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",0.37444,1.06,0.371,267,0.484,"fludroxycortide, methylprednisolone, prednisolone.acetate, deflazacort, desonide, triamcinolone, fluocinolone.acetonide, triamcinolone.acetonide, beclomethasone.dipropionate, prednisolone.hemisuccinate",0.430626090384954,0.315154638355588,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.38652,1.15,0.274,310,0.414,"JNJ.16259685, felbamate, CGP.37849, kynurenic.acid, SIB.1757, CPP, diazooxonorleucine",0.562249437179612,0.382999658879101,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.48271,-1.3,0.182,1040,0.386,"LY2090314, kenpaullone, CHIR.99021, AZD2858, CHIR.98014",0.739928612014925,0.413412695328245,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",-0.40248,-1.06,0.384,1243,0.574,"danusertib, lestaurtinib",0.415668775632469,0.241088107602027,FALSE
+"H1299","Pearson.est","HDAC inhibitor",-0.43771,-1.18,0.257,984,0.469,"givinostat, PCI.24781, entinostat, AR.42, SB.939, pyroxamide, romidepsin, tacedinaline, M.344, dacinostat, mocetinostat",0.590066876668705,0.328827157284917,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",0.41462,1.16,0.289,290,0.426,"astemizole, famotidine, epinastine, nizatidine, zolantidine, BF2.649",0.539102157243452,0.370590400897281,FALSE
+"H1299","Pearson.est","HSP inhibitor",-0.41695,-1.1,0.34,951,0.533,"alvespimycin, SNX.5422, SNX.2112, NVP.AUY922, NMS.E973, XL888, PU.H71",0.468521082957745,0.273272790973428,FALSE
+"H1299","Pearson.est","JAK inhibitor",-0.39481,-1.05,0.395,953,0.57,"WHI.P154, AT.9283, TG.02, tozasertib, TG.101348, TG.101209, PRT062070, lestaurtinib",0.40340290437354,0.244125144327509,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.28942,-0.756,0.75,914,0.867,"cediranib, imatinib, midostaurin, KI.8751, pazopanib, OSI.930",0.1249387366083,0.0619809025237897,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.43598,1.3,0.162,340,0.392,"refametinib, PD.198306, PD.184352, trametinib, TAK.733, AS.703026, PD.0325901, AZD8330, cobimetinib, PD.318088, Ro.4987655, PD.98059",0.790484985457369,0.406713932979543,FALSE
+"H1299","Pearson.est","MET inhibitor",0.53817,1.59,0.055,151,0.296,"NVP.BVU972, PF.04217903",1.25963731050576,0.528708288941061,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.43628,-1.14,0.317,933,0.491,"vinblastine, vinflunine, D.64131, colchicine, cabazitaxel",0.498940737782249,0.308918507877032,FALSE
+"H1299","Pearson.est","mTOR inhibitor",-0.43431,-1.15,0.283,892,0.495,"ku.0063794, PI.103, WYE.354, WYE.125132, AZD8055, PF.04691502, PKI.179, XL388, OSI.027, deforolimus, sirolimus, torin.2, torin.1, PF.05212384",0.54821356447571,0.305394801066431,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.54396,-1.45,0.11,856,0.408,"bindarit, betulinic.acid, EVP4593, Ro.106.9920, BAY.11.7085, curcumin, tyloxapol, parthenolide",0.958607314841775,0.38933983691012,FALSE
+"H1299","Pearson.est","opioid receptor agonist",0.40015,1.16,0.261,814,0.426,"salvinorin.a, BW.180C, trimebutine, ADL5859, cebranopadol, spiradoline",0.583359492661719,0.370590400897281,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",0.21422,0.617,0.916,121,0.947,"SB.242235",0.0381045263321496,0.0236500209967266,FALSE
+"H1299","Pearson.est","PARP inhibitor",-0.56113,-1.51,0.0767,983,0.493,"niraparib, olaparib, talazoparib, PJ.34",1.11520463605102,0.30715308072277,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.27714,-0.735,0.774,940,0.854,"nintedanib, orantinib, imatinib, axitinib, crenolanib, CP.673451, KI.8751, pazopanib",0.111259039317107,0.068542129310995,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.52213,-1.37,0.136,806,0.415,"alexidine, GSK2830371, sodium.stibogluconate, mycophenolic.acid, CID.5458317",0.866461091629782,0.381951903287907,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",0.25084,0.748,0.791,461,0.93,"enoximone, trequinsin, avanafil, YM.976, papaverine",0.101823516502323,0.0315170514460649,FALSE
+"H1299","Pearson.est","PI3K inhibitor",0.23334,0.651,0.887,34,0.947,"GDC.0980, idelalisib, alpelisib",0.0520763801682736,0.0236500209967266,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.45409,-1.23,0.245,744,0.433,"GSK461364, HMN.214, BI.2536, rigosertib, volasertib",0.610833915635468,0.363512103646635,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",0.54307,1.56,0.0588,131,0.221,"levonorgestrel, norgestrel, nomegestrol.acetate, danazol",1.23062267392386,0.655607726314889,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.61763,-1.65,0.0334,862,0.405,"carfilzomib, ixazomib, ONX.0914, oprozomib, ixazomib.citrate, delanzomib, MG.132",1.47625353318844,0.392544976785331,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.50024,-1.35,0.145,1062,0.373,"cycloheximide, homoharringtonine, bruceantin, harringtonine, anguidine, methacycline, florfenicol, mercaptopurine, tedizolid.phosphate, thiostrepton",0.838631997765025,0.428291168191312,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.50345,-1.35,0.153,1234,0.373,"BMS.599626, tyrphostin.A9, PP.121",0.815308569182401,0.428291168191312,FALSE
+"H1299","Pearson.est","RAF inhibitor",-0.4455,-1.2,0.245,1131,0.458,"PLX.4720, RAF265, CEP.32496, SB.590885",0.610833915635468,0.339134521996131,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",0.36451,1.07,0.326,862,0.495,"vandetanib, regorafenib, sorafenib, apatinib, sunitinib, cabozantinib",0.486782399932061,0.305394801066431,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",-0.59604,-1.59,0.0537,934,0.463,"adapalene, fenretinide, CD.437, tamibarotene, LE.135",1.27002571430044,0.334419008982047,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.53023,-1.46,0.0978,947,0.479,"fludarabine.phosphate, cladribine, LY2334737, triapine, clofarabine",1.0096611452124,0.319664486585437,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",-0.18027,-0.482,0.991,1266,0.983,"lerisetron",0.00392634551472468,0.00744648216786438,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.52735,-1.42,0.116,1138,0.424,"brivaracetam, cibenzoline, benzocaine, benzethonium, ajmaline",0.935542010773082,0.372634143407267,FALSE
+"H1299","Pearson.est","src inhibitor",0.24702,0.697,0.812,304,0.969,"PP.1, masitinib, saracatinib",0.0904439707588247,0.0136762229492347,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.28395,-0.773,0.724,974,0.888,"sulconazole, terconazole",0.140261433802853,0.051587034221399,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",0.43451,1.29,0.171,159,0.372,"SB.431542, LY2109761",0.767003889607846,0.429457060118102,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",0.42217,1.25,0.186,89,0.392,"carmofur, capecitabine",0.730487055782084,0.406713932979543,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.49806,-1.36,0.13,946,0.405,"teniposide, rubitecan, irinotecan, doxorubicin, valrubicin, topotecan, genz.644282, beta.lapachone, etoposide, exatecan.mesylate, nemorubicin, epirubicin, etoposide.phosphate, voreloxin, dexrazoxane",0.886056647693163,0.392544976785331,FALSE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.50412,-1.34,0.165,708,0.367,"oxibendazole, CYT.997, plinabulin, epothilone.b, podophyllotoxin, dolastatin.10, verubulin, vincristine, flubendazole, indibulin, vindesine, BNC105, vinblastine, fosbretabulin, mebendazole, combretastatin.A.4, docetaxel, fenbendazole, paclitaxel, KX2.391, parbendazole, nocodazole, taltobulin, albendazole, vinorelbine",0.782516055786094,0.435333935747911,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",-0.31868,-0.849,0.635,861,0.835,"cabozantinib, NVP.TAE226, AV.412, aminopurvalanol.a, GTP.14564, UNC2250, tivantinib, BMS.599626, tyrphostin.A9, PP.121",0.197226274708024,0.0783135245163979,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.23636,-0.648,0.885,914,0.937,"cediranib, nintedanib, orantinib, semaxanib, axitinib, ENMD.2076, lucitanib, RAF265, KI.8751, AEE788, pazopanib, OSI.930",0.0530567293021746,0.0282604091122217,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.76861,2.2,0,228,0.0564,"calcitriol, maxacalcitol, tacalcitol, doxercalciferol, alfacalcidol",Inf,1.24872089601666,TRUE
+"H1703","Pearson.est","EGFR inhibitor",0.24664,0.739,0.77,565,0.895,"BMS.599626, OSI.420, PD.168393, TAK.285, osimertinib, lapatinib, WZ.4002, AEE788, erlotinib, BMS.690514, ARRY.334543, neratinib, GW.583340, vandetanib, pelitinib, tucatinib, PD.153035, BIBX.1382, afatinib, AZD8931, canertinib, XL.647, dacomitinib",0.113509274827518,0.048176964684088,FALSE
+"H1703","Pearson.est","Abl kinase inhibitor",-0.41455,-1.22,0.234,1061,0.633,"bosutinib, ponatinib, dasatinib, flumatinib, bafetinib, GZD824",0.630784142589857,0.198596289982645,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",0.39084,1.2,0.252,70,0.684,"oxiracetam, nefiracetam",0.598599459218456,0.164943898279884,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.5153,-1.51,0.0942,995,0.615,"dicycloverine, iododexetimide, hyoscyamine, diphemanil",1.02594909720712,0.211124884224583,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",-0.25729,-0.749,0.743,752,0.852,"PSB.1115, theophylline, MRS.1220, SCH.58261",0.129011186239425,0.0695604052332999,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",-0.29236,-0.877,0.588,841,0.798,"A61603, methyldopa, ritodrine, norepinephrine, metaraminol, buphenine, xylazine, epinephrine, isoetharine",0.230622673923862,0.0979971086492706,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",0.31959,0.949,0.498,250,0.899,"RS.17053, atenolol...., dihydroergocristine, idazoxan, vincamine",0.302770657240282,0.0462403082667712,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.51674,1.54,0.0792,429,1,"ONC201, MK.2206, palomid.529, GSK2110183, GDC.0068, AZD5363, CCT128930, triciribine",1.10127481841051,0,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.48621,-1.4,0.133,1350,0.77,"GW.788388, DMH1, SB.505124",0.876148359032914,0.113509274827518,FALSE
+"H1703","Pearson.est","antioxidant",-0.29584,-0.861,0.613,1170,0.8,"mesna, chlorogenic.acid",0.212539525481585,0.0969100130080564,FALSE
+"H1703","Pearson.est","AP inhibitor",-0.30177,-0.882,0.559,1240,0.818,"GDC.0152, birinapant",0.252588192113577,0.087246696328677,FALSE
+"H1703","Pearson.est","ATPase inhibitor",0.4268,1.29,0.187,278,0.664,"rabeprazole, digitoxigenin, thonzonium, digitoxin",0.728158393463501,0.177831920631982,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.42279,-1.23,0.227,1271,0.659,"TAK.901, CYC116, GSK1070916, danusertib, barasertib.HQPA, SNS.314, AT.9283, hesperadin",0.643974142806877,0.18111458540599,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.21954,-0.64,0.87,966,0.939,"tilmicosin, azalomycin.b, radezolid",0.0604807473813815,0.0273344077338891,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.69109,-2.05,0.00193,1145,0.0982,"lomefloxacin, nadifloxacin, sarafloxacin, novobiocin, trovafloxacin, finafloxacin",2.71444269099223,1.00788851221305,TRUE
+"H1703","Pearson.est","BCL inhibitor",-0.23616,-0.687,0.791,907,0.911,"navitoclax, obatoclax, ABT.737, HA14.1",0.101823516502323,0.0404816230270017,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",-0.45762,-1.32,0.203,1061,0.636,"bosutinib, ponatinib, dasatinib, flumatinib, bafetinib, GZD824",0.692503962086787,0.196542884351586,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.2508,0.759,0.739,123,0.892,"eprinomectin, nefiracetam, lorazepam",0.131355561605174,0.0496351456238769,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",-0.71574,-2.09,0.00571,1095,0.146,"I.BET151, OTX015, JQ1...., bromosporine",2.24336389175415,0.835647144215563,TRUE
+"H1703","Pearson.est","calcium channel blocker",0.32354,0.978,0.449,160,0.881,"fendiline, tetrandrine, penfluridol",0.347753658996677,0.0550240915879521,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.26318,-0.755,0.731,887,0.868,"PF.04136309, SB.225002, RS.504393",0.13608262304214,0.0614802748235081,FALSE
+"H1703","Pearson.est","CDK inhibitor",0.2322,0.693,0.829,393,0.907,"AZD5438, CR8..R., ribociclib, arcyriaflavin.a, aminopurvalanol.a, NU6027, indisulam, BMS.265246",0.0814454694497265,0.0423927129399047,FALSE
+"H1703","Pearson.est","CHK inhibitor",0.29018,0.876,0.562,468,0.896,"LY2606368, AZD7762, CHIR.124, SB.218078",0.250263684430939,0.0476919903378748,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",-0.3192,-0.932,0.506,946,0.89,"ketoprofen, FK.3311, ramifenazone, tepoxalin, aspirin, pterostilbene, sulfasalazine, indoprofen, piroxicam, amfenac, phenazone",0.295849483160201,0.0506099933550872,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",0.26476,0.784,0.695,356,0.876,"cobicistat, metyrapone, clotrimazole",0.158015195409886,0.0574958938319193,FALSE
+"H1703","Pearson.est","DNA alkylating agent",0.26855,0.803,0.654,117,0.902,"estramustine, satraplatin, TH.302",0.184422251675733,0.0447934624580583,FALSE
+"H1703","Pearson.est","DNA inhibitor",0.3525,1.06,0.361,118,0.834,"oxaliplatin, sangivamycin, pibenzimol, busulfan",0.442492798094342,0.0788339493622613,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",0.23075,0.693,0.837,432,0.907,"fdcyd, SGI.1027, disulfiram",0.07727454200674,0.0423927129399047,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",0.43353,1.32,0.164,78,0.74,"idoxuridine, cidofovir",0.785156151952302,0.130768280269024,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",0.43571,1.3,0.188,183,0.709,"CB.10.277, azodicarbonamide, capecitabine, enocitabine, floxuridine",0.72584215073632,0.149353764816933,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.28491,0.88,0.562,151,0.926,"sertindole, paliperidone, oxiperomide, nemonapride",0.250263684430939,0.0333890133180656,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",-0.30193,-0.889,0.574,1245,0.866,"PPT, erteberel",0.241088107602027,0.0624821079826534,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",0.35064,1.05,0.35,481,0.768,"raloxifene, fulvestrant, clomifene, danazol",0.455931955649724,0.114638779968488,FALSE
+"H1703","Pearson.est","FGFR inhibitor",0.48051,1.45,0.103,96,0.737,"orantinib, lucitanib, lenvatinib",0.987162775294828,0.132532512140949,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",0.29223,0.866,0.574,23,0.848,"tandutinib, sorafenib",0.241088107602027,0.0716041477432862,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",-0.19081,-0.561,0.951,883,0.962,"fluticasone.propionate, fludroxycortide, triamcinolone, prednisolone, halcinonide, methylprednisolone, beclomethasone.dipropionate, clobetasol.propionate, flumethasone.pivalate, prednisolone.hemisuccinate, betamethasone",0.0218194830625861,0.0168249279621871,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",-0.33194,-0.965,0.503,905,0.861,"ACDPP, tiletamine, kynurenic.acid, diazooxonorleucine, latrepirdine, IEM1754",0.298432014944073,0.0649968485463452,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",-0.29098,-0.854,0.604,1213,0.785,"CHIR.99021, tideglusib",0.218963061378868,0.105130343254747,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",-0.31571,-0.925,0.535,1096,0.868,"GSK1838705A, GSK1904529A, danusertib",0.271646217978772,0.0614802748235081,FALSE
+"H1703","Pearson.est","HDAC inhibitor",0.401,1.21,0.234,231,0.715,"entinostat, PCI.24781, romidepsin, givinostat, M.344, scriptaid, JNJ.26481585, NSC.3852, ACY.1215, R306465",0.630784142589857,0.145693958198919,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.21958,0.656,0.832,438,0.877,"levocetirizine, astemizole, zolantidine, tiotidine, nizatidine, ranitidine, cyproheptadine, lafutidine",0.0798766737092761,0.0570004066339595,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.58065,-1.71,0.0377,1212,0.316,"pitavastatin, mevastatin, atorvastatin, lovastatin",1.42365864979421,0.500312917381596,FALSE
+"H1703","Pearson.est","HSP inhibitor",0.29159,0.865,0.579,465,0.82,"PU.H71, guanidine, SNX.2112, alvespimycin, SNX.5422, BIIB021, XL888, KW.2478",0.237321436272564,0.0861861476162833,FALSE
+"H1703","Pearson.est","JAK inhibitor",-0.33407,-0.993,0.426,1071,0.885,"CEP.33779, filgotinib, WHI.P154, ruxolitinib, baricitinib, AT.9283",0.370590400897281,0.0530567293021746,FALSE
+"H1703","Pearson.est","KIT inhibitor",0.47297,1.42,0.121,240,0.698,"tandutinib, sorafenib, pazopanib, lenvatinib, masitinib, cediranib, KI.8751, vatalanib",0.91721462968355,0.156144577376839,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.58258,-1.73,0.0342,1129,0.354,"idasanutlin, AMG.232, nutlin.3, serdemetan",1.46597389394386,0.450996737974212,FALSE
+"H1703","Pearson.est","MEK inhibitor",-0.64077,-1.9,0.00792,1014,0.184,"trametinib, refametinib, PD.184352, cobimetinib, U.0126, MEK162, AZD8330, Ro.4987655, AS.703026, PD.0325901, TAK.733, selumetinib, PD.198306, PD.318088, MEK1.2.inhibitor",2.10127481841051,0.735182176990464,TRUE
+"H1703","Pearson.est","MET inhibitor",-0.44773,-1.28,0.193,1360,0.609,"NVP.BVU972, INC.280",0.714442690992226,0.215382707367125,FALSE
+"H1703","Pearson.est","microtubule inhibitor",0.22674,0.672,0.834,112,0.882,"triclabendazole, secnidazole",0.0788339493622613,0.0545314148681803,FALSE
+"H1703","Pearson.est","mTOR inhibitor",0.34718,1.05,0.359,488,0.768,"ku.0063794, palomid.529, WAY.600, GSK2126458, deforolimus, LY3023414, sirolimus, LY303511, PKI.179, OSI.027, torin.2, AZD2014, everolimus, torin.1, temsirolimus, PI.103, voxtalisib",0.444905551421681,0.114638779968488,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.14874,-0.429,0.994,760,0.993,"bortezomib, EVP4593, BAY.11.7082, curcumin, bindarit, parthenolide, Ro.106.9920, BAY.11.7085",0.00261361560268669,0.00305075150461883,FALSE
+"H1703","Pearson.est","opioid receptor agonist",0.22498,0.685,0.825,224,0.891,"BW.180C, cebranopadol",0.0835460514500749,0.0501222959631252,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",-0.37941,-1.1,0.312,747,0.7,"SB.239063, CMPD.1, VX.702, TAK.715",0.505845405981557,0.154901959985743,FALSE
+"H1703","Pearson.est","PARP inhibitor",0.29197,0.882,0.555,523,0.962,"E7449, niraparib, AZD2461, PJ.34, talazoparib",0.255707016877324,0.0168249279621871,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.44518,1.34,0.173,270,0.779,"orantinib, tandutinib, sorafenib, pazopanib, axitinib, lenvatinib, masitinib, KI.8751, vatalanib, linifanib",0.761953896871205,0.108462542327436,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.47495,-1.37,0.139,1094,0.594,"menadione, GSK2830371, sodium.stibogluconate, AS.1949490, CID.5458317",0.856985199745905,0.226213555018806,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",0.35589,1.07,0.341,347,0.863,"trequinsin, avanafil, anagrelide, enoximone",0.467245621007502,0.0639892042847904,FALSE
+"H1703","Pearson.est","PI3K inhibitor",0.35334,1.07,0.358,275,0.863,"YM.201636, pilaralisib, CH5132799, GSK2126458, LY3023414, ZSTK.474, PI3K.IN.2, LY303511, TG100.115, PKI.179, taselisib",0.446116973356126,0.0639892042847904,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.34332,-0.97,0.473,781,0.891,"GW.843682X, HMN.214, BI.2536, volasertib, rigosertib, NMS.1286937",0.325138859262188,0.0501222959631252,FALSE
+"H1703","Pearson.est","potassium channel blocker",-0.46474,-1.37,0.133,908,0.594,"ibutilide, mepivacaine, dofetilide, oleoylethanolamide, ML133",0.876148359032914,0.226213555018806,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.27845,-0.807,0.674,389,0.838,"melengestrol.acetate, levonorgestrel, danazol, norethindrone.acetate, norgestrel, norethindrone, nomegestrol.acetate, tanaproget, dienogest",0.17134010346468,0.0767559813697235,FALSE
+"H1703","Pearson.est","proteasome inhibitor",-0.39452,-1.15,0.295,1016,0.683,"ixazomib, MG.132, oprozomib",0.530177984021837,0.165579296318467,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.31286,-0.921,0.523,1243,0.841,"emetine, anguidine, harringtonine, bruceantin, mercaptopurine",0.281498311132726,0.0752040042020878,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.31288,0.935,0.527,308,0.886,"BMS.599626, AV.412, tyrphostin.A9, PP.121",0.278189384787453,0.0525662781129492,FALSE
+"H1703","Pearson.est","RAF inhibitor",-0.44601,-1.31,0.191,1133,0.603,"dabrafenib, TAK.632, CEP.32496, AZ.628, LGX818, PLX.4720",0.718966632752272,0.219682687859849,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.51022,1.51,0.0979,48,0.719,"sorafenib, apatinib",1.00921730819686,0.143271109617117,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",-0.2597,-0.763,0.727,1314,0.881,"adapalene",0.138465589140962,0.0550240915879521,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",0.56068,1.67,0.0413,243,1,"hydroxyurea, fludarabine.phosphate, triapine, gemcitabine, clofarabine, cladribine",1.3840499483436,0,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",-0.38154,-1.14,0.291,1155,0.662,"SB.200646, SB.216641, tropisetron, lerisetron, RS.16566",0.536107011014093,0.1791420105603,FALSE
+"H1703","Pearson.est","sodium channel blocker",0.19754,0.592,0.9,425,0.918,"butamben, brivaracetam, triamterene, lappaconite, mexiletine, oxcarbazepine",0.0457574905606751,0.0371573187987575,FALSE
+"H1703","Pearson.est","src inhibitor",-0.40942,-1.19,0.269,1061,0.65,"bosutinib, PP.2, dasatinib, PP.1, KX2.391",0.570247719997592,0.187086643357144,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.48381,-1.39,0.129,1254,0.698,"posaconazole, sulconazole",0.889410289700751,0.156144577376839,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.25571,0.787,0.683,1048,0.9,"SB.431542, repsox, D.4476, SB.525334, adaprev, LY2109761",0.165579296318467,0.0457574905606751,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",0.63346,1.89,0.0186,255,0.776,"capecitabine, raltitrexed, carmofur",1.73048705578208,0.110138278741812,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.21702,-0.625,0.892,909,0.931,"mitoxantrone, genz.644282, etoposide.phosphate, beta.lapachone, doxorubicin, epirubicin, topotecan, idarubicin, TAS.103, teniposide",0.0496351456238769,0.0310503190186574,FALSE
+"H1703","Pearson.est","tubulin polymerization inhibitor",-0.29886,-0.883,0.607,1043,0.846,"podophyllotoxin, vindesine, verubulin, taltobulin, mebendazole, CYT.997, BNC105, vinblastine, KX2.391, oxibendazole",0.216811308924742,0.0726296369609765,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.28778,0.867,0.621,308,0.879,"BMS.599626, hypericin, sorafenib, apatinib, AV.412, AMG.208, tyrphostin.A9, aminopurvalanol.a, PP.121",0.20690839982342,0.0560111249262281,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",0.41452,1.24,0.212,373,0.709,"orantinib, sorafenib, pazopanib, axitinib, lucitanib, lenvatinib, cediranib, KI.8751, tivozanib, vatalanib, golvatinib, linifanib, AEE788, MGCD.265, BMS.690514, TG.100572, motesanib",0.673664139071249,0.149353764816933,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.51284,1.53,0.0977,369,0.845,"maxacalcitol, paricalcitol, calcitriol, tacalcitol, doxercalciferol",1.01010543628123,0.0731432910503077,FALSE
+"H460","Pearson.est","EGFR inhibitor",-0.17666,-0.608,0.923,753,1,"PD.168393, erlotinib, BIBU.1361, icotinib, OSI.420, gefitinib, WZ.3146, tyrphostin.AG.1478, AEE788, CGP.52411, WZ.4002, AZD8931, BMS.599626, canertinib, BMS.690514, pelitinib, dacomitinib, brigatinib, GW.583340, dovitinib, CP.724714, TAK.285, osimertinib, FERb.033, afatinib, vandetanib, rociletinib, poziotinib, CNX.2006, tucatinib, salvianolic.acid.B",0.0347982989740879,0,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",0.37845,1.08,0.362,433,0.674,"dasatinib, GZD824, bosutinib, flumatinib, metatinib, ponatinib",0.441291429466834,0.17134010346468,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",0.50599,1.42,0.0979,36,0.56,"pilocarpine, nefiracetam",1.00921730819686,0.2518119729938,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.46661,1.32,0.146,580,0.63,"diphemanil, iododexetimide, dicycloverine, hyoscyamine, methscopolamine",0.835647144215563,0.200659450546418,FALSE
+"H460","Pearson.est","adenosine receptor antagonist",0.3059,0.876,0.618,729,0.771,"sulmazole, PSB.1115, istradefylline, MRS.1220, CGS.15943",0.209011524911184,0.112945621949043,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",0.39769,1.16,0.287,392,0.592,"isoetharine, xylazine, epinephrine, buphenine, A61603, clenbuterol, methyldopa, oxymetazoline",0.542118103266008,0.22767829327708,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",0.20139,0.574,0.936,701,0.935,"metoprolol, naftidrofuryl, oxprenolol, propranolol, dihydroergocristine, prazosin, imiloxan, atenolol...., atipamezole, dronedarone, RS.17053",0.0287241512618947,0.0291883891274822,FALSE
+"H460","Pearson.est","AKT inhibitor",0.42284,1.23,0.222,455,0.583,"AZD5363, ONC201, A.674563, palomid.529, AT7867, CCT128930, triciribine",0.653647025549361,0.234331445240986,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33225,0.965,0.514,625,0.809,"GW.788388, SB.505124, DMH1, AZD3463, NVP.TAE684, crizotinib",0.289036881004724,0.0920514783877277,FALSE
+"H460","Pearson.est","androgen receptor antagonist",0.54573,1.59,0.0388,403,1,"flutamide, RU.58841, bicalutamide, nilutamide",1.41116827440579,0,FALSE
+"H460","Pearson.est","antioxidant",-0.43755,-1.49,0.0874,599,0.369,"taurine, chlorogenic.acid, benfotiamine, rutin, mesna, trolox",1.0584885673656,0.43297363384094,FALSE
+"H460","Pearson.est","AP inhibitor",-0.56481,-1.93,0.0118,1242,0.239,"tanshinone.i, birinapant, LCL.161, GDC.0152",1.92811799269387,0.621602099051862,TRUE
+"H460","Pearson.est","ATPase inhibitor",-0.14287,-0.485,0.967,1347,0.979,"rabeprazole",0.0145735259169983,0.00921730819686218,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",0.41054,1.21,0.237,677,0.599,"ENMD.2076, GSK1070916, PF.03814735, SNS.314, barasertib.HQPA, CCT137690, AMG900, MLN.8054, CYC116, AT.9283, danusertib, alisertib, MK.5108, ZM.447439, hesperadin, KW.2449, aurora.a.inhibitor.i, MK.8745",0.625251653989896,0.222573177610689,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.38796,1.11,0.347,514,0.654,"tedizolid, tilmicosin, josamycin, valnemulin, radezolid",0.459670525209126,0.184422251675733,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.24146,-0.817,0.661,847,0.889,"norfloxacin, sarafloxacin, sparfloxacin, finafloxacin, nadifloxacin, trovafloxacin",0.17979854051436,0.0510982390297863,FALSE
+"H460","Pearson.est","BCL inhibitor",0.23685,0.672,0.848,73,0.885,"gossypol",0.0716041477432862,0.0530567293021746,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",0.50454,1.46,0.078,433,0.736,"dasatinib, GZD824, bosutinib, flumatinib, metatinib, ponatinib",1.10790539730952,0.133122185662501,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.41109,1.18,0.259,529,0.592,"nefiracetam, ZK.93423, eprinomectin, lorazepam, ivermectin, CL.218872, CGS.20625",0.586700235918748,0.22767829327708,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.29584,-0.99,0.448,405,0.882,"bromosporine, PFI.1, OTX015, JQ1...., I.BET151, I.BET.762",0.348721986001856,0.0545314148681803,FALSE
+"H460","Pearson.est","calcium channel blocker",0.36849,1.05,0.401,684,0.716,"pranidipine, carboxyamidotriazole, efonidipine.monoethanolate, cinnarazine, mibefradil, SR.33805",0.396855627379818,0.145086977692144,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",0.32036,0.917,0.57,706,0.804,"RS.504393, PF.04136309, navarixin, ZK811752",0.244125144327509,0.0947439512515487,FALSE
+"H460","Pearson.est","CDK inhibitor",0.26118,0.756,0.77,224,0.866,"JNJ.7706621, palbociclib, kenpaullone, abemaciclib, ribociclib, TG.02",0.113509274827518,0.0624821079826534,FALSE
+"H460","Pearson.est","CHK inhibitor",-0.30117,-0.994,0.421,412,0.996,"SB.218078, AZD7762, LY2606368, SCH.900776, CHIR.124, PF.477736, LY2603618",0.375717904164332,0.00174066157630127,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",0.24256,0.696,0.837,660,0.891,"meloxicam, curcumin, tepoxalin, metoxibutropate, ramifenazone, suxibuzone, FR.122047, acetylsalicylsalicylic.acid, ketoprofen, tryptanthrin, FK.3311, indoprofen",0.07727454200674,0.0501222959631252,FALSE
+"H460","Pearson.est","DNA alkylating agent",0.24566,0.703,0.821,874,0.898,"streptozotocin, temozolomide, dacarbazine, ifosfamide, carboplatin, dianhydrogalactitol, TH.302, melphalan, mitomycin.c",0.0856568428805592,0.0467236633326956,FALSE
+"H460","Pearson.est","DNA inhibitor",0.28938,0.832,0.669,303,0.791,"metronidazole, tirapazamine, nithiamide, valrubicin, busulfan",0.174573882232177,0.101823516502323,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.26735,-0.869,0.59,366,0.954,"decitabine, fdcyd, RG108, azacitidine, disulfiram, SGI.1027",0.229147988357856,0.0204516252959049,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",0.50792,1.45,0.101,530,0.673,"trifluridine, idoxuridine, cidofovir, foscarnet, famciclovir",0.995678626217357,0.171984935776023,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",0.53376,1.53,0.0554,418,0.732,"capecitabine, azodicarbonamide, artesunate, nelarabine, anisomycin, floxuridine, artemisinin, CB.10.277, estramustine.phosphate",1.25649023527157,0.135488918941608,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",0.31592,0.9,0.577,329,0.78,"paliperidone, lurasidone, piperacetazine, oxiperomide, nemonapride, amisulpride, UH.232....",0.238824186844269,0.10790539730952,FALSE
+"H460","Pearson.est","estrogen receptor agonist",0.30878,0.903,0.596,161,0.792,"estradiol, estradiol.cypionate",0.224753740259764,0.101274818410506,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",0.2932,0.836,0.663,375,0.801,"tamoxifen, toremifene, danazol",0.178486471595227,0.0963674839157623,FALSE
+"H460","Pearson.est","FGFR inhibitor",0.4366,1.25,0.196,383,0.592,"MK.2461, AZD4547, PD.173074, nintedanib, regorafenib",0.707743928643524,0.22767829327708,FALSE
+"H460","Pearson.est","FLT3 inhibitor",0.50781,1.46,0.0849,490,0.736,"gilteritinib, midostaurin, ENMD.2076, TG.02, tandutinib, lestaurtinib, quizartinib, pacritinib, ponatinib, sunitinib, TG.101348",1.07109230975605,0.133122185662501,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",0.31617,0.912,0.569,192,0.794,"methylprednisolone, clobetasol.propionate, halobetasol.propionate, ciclesonide, halcinonide, deflazacort, desonide",0.244887733604929,0.100179497572904,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.20802,0.59,0.938,176,0.94,"CGP.37849, tiletamine, latrepirdine",0.0277971616209356,0.0268721464003014,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",0.3285,0.934,0.549,870,0.809,"TWS.119, kenpaullone, LY2090314, CHIR.99021, CHIR.98014, tideglusib, indirubin, GSK.3.inhibitor.IX",0.260427655549908,0.0920514783877277,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",0.4499,1.29,0.191,538,0.563,"GSK1838705A, lestaurtinib, AZD3463, GW.441756, danusertib",0.718966632752272,0.249491605148654,FALSE
+"H460","Pearson.est","HDAC inhibitor",0.28455,0.814,0.679,952,0.803,"pyroxamide, trichostatin.a, RG2833, nexturastat.a, vorinostat, tacedinaline, NSC.3852, panobinostat, entinostat, SB.939, belinostat, mocetinostat, JNJ.26481585, AR.42, M.344, givinostat, RGFP966, R306465, resminostat, dacinostat, scriptaid, chidamide, romidepsin",0.168130225719498,0.095284454721319,FALSE
+"H460","Pearson.est","histamine receptor antagonist",0.34067,0.95,0.518,426,0.819,"tecastemizole, epinastine, nizatidine, BF2.649, lafutidine, levocetirizine, famotidine, ICI.162846",0.285670240254767,0.0867160982395816,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.49004,1.37,0.125,259,0.588,"lovastatin, atorvastatin, mevastatin",0.903089986991944,0.230622673923862,FALSE
+"H460","Pearson.est","HSP inhibitor",0.4142,1.18,0.247,645,0.592,"guanidine, XL888, SNX.2112, NVP.AUY922, BIIB021, ganetespib, VER.49009, PU.H71",0.607303046740334,0.22767829327708,FALSE
+"H460","Pearson.est","JAK inhibitor",0.49675,1.41,0.123,526,0.537,"WHI.P154, CEP.33779, ruxolitinib, AZ960, TG.02, AZD1480, lestaurtinib, PRT062070, TG.101209, pacritinib, filgotinib, TG.101348, AT.9283",0.910094888560602,0.270025714300444,FALSE
+"H460","Pearson.est","KIT inhibitor",0.43992,1.29,0.179,766,0.563,"dasatinib, midostaurin, KI.8751, tandutinib, OSI.930, motesanib, regorafenib, sunitinib, masitinib, telatinib, vatalanib, lenvatinib, cediranib",0.747146969020107,0.249491605148654,FALSE
+"H460","Pearson.est","MEK inhibitor",-0.28997,-0.964,0.478,600,0.846,"arctigenin, cobimetinib, refametinib, PD.184352, trametinib, PD.318088, selumetinib, U.0126, TAK.733, AS.703026, PD.198306, Ro.4987655, PD.0325901, MEK1.2.inhibitor, AZD8330, MEK162, BIX.02188",0.320572103387881,0.0726296369609765,FALSE
+"H460","Pearson.est","MET inhibitor",0.43629,1.24,0.202,657,0.587,"PHA.665752, NVP.BVU972, INC.280, PF.04217903, LY2801653",0.694648630553376,0.231361898752386,FALSE
+"H460","Pearson.est","microtubule inhibitor",0.33885,0.976,0.472,612,0.83,"secnidazole, estramustine.phosphate, triclabendazole, cabazitaxel",0.326058001365912,0.0809219076239261,FALSE
+"H460","Pearson.est","mTOR inhibitor",0.30775,0.885,0.593,695,0.772,"PP242, palomid.529, WAY.600, temsirolimus, LY303511, torin.1, GSK2126458, NVP.BEZ235, XL388, AZD8055, MLN0128, sirolimus, GDC.0980, deforolimus, LY3023414, OSI.027, torin.2, PKI.179",0.226945306635737,0.112382699664264,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",0.46289,1.31,0.172,217,0.617,"curcumin, EVP4593, bortezomib, betulinic.acid",0.764471553092451,0.209714835966758,FALSE
+"H460","Pearson.est","opioid receptor agonist",0.47023,1.34,0.144,593,0.62,"cebranopadol, salvinorin.a, trimebutine, ADL5859, spiradoline",0.84163750790475,0.207608310501746,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",0.4497,1.29,0.158,646,0.563,"CMPD.1, TAK.715, VX.702, SB.242235, talmapimod",0.801342913045577,0.249491605148654,FALSE
+"H460","Pearson.est","PARP inhibitor",0.54724,1.58,0.0492,362,0.707,"AG.14361, PJ.34, olaparib, talazoparib",1.30803489723264,0.150580586203101,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3893,1.11,0.328,557,0.654,"dasatinib, CP.673451, KI.8751, tandutinib, motesanib, nintedanib, regorafenib, ponatinib, sunitinib, masitinib, SU014813, telatinib",0.484126156288321,0.184422251675733,FALSE
+"H460","Pearson.est","phosphatase inhibitor",0.31521,0.917,0.563,190,0.804,"CID.5458317, mycophenolate.mofetil, sodium.stibogluconate",0.249491605148654,0.0947439512515487,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",0.33836,0.968,0.499,409,0.824,"avanafil, EMD.53998, trequinsin, anagrelide, YM.976",0.30189945437661,0.0840727883028842,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.16395,-0.563,0.95,221,1,"GDC.0941, LY303511, BGT226, GSK2126458, NVP.BEZ235, TG100.115, taselisib, GDC.0980, LY3023414, TG.100713, ZSTK.474, PKI.179, idelalisib, alpelisib, buparlisib, CUDC.907, CH5132799, PI3K.IN.2, SB.2343, voxtalisib, PI.103, pilaralisib, PIK.75, AZD6482, PF.05212384, PF.04691502, YM.201636",0.0222763947111523,0,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.54094,-1.82,0.0347,740,0.129,"GW.843682X, GSK461364, rigosertib, volasertib, HMN.214, BI.2536, NMS.1286937",1.45967052520913,0.889410289700751,TRUE
+"H460","Pearson.est","potassium channel blocker",0.59864,1.71,0.0225,402,1,"dofetilide, meglitinide, oleoylethanolamide, mepivacaine, ML133",1.64781748188864,0,FALSE
+"H460","Pearson.est","progesterone receptor agonist",-0.36735,-1.26,0.196,1295,0.639,"levonorgestrel, nomegestrol.acetate, norethindrone",0.707743928643524,0.1944991418416,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.26065,0.754,0.771,683,0.853,"bortezomib, carfilzomib, ixazomib, oprozomib",0.112945621949043,0.069050968832477,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.24934,-0.866,0.615,1228,0.873,"clofoctol, harringtonine, homoharringtonine, bruceantin, anguidine, chloramphenicol.palmitate",0.211124884224583,0.0589857562944303,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",0.42007,1.2,0.255,370,0.595,"NVP.TAE226, mubritinib",0.593459819566045,0.22548303427145,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.20308,-0.668,0.85,277,1,"vemurafenib, regorafenib, TAK.632, CEP.32496, GDC.0879, AZ.628, sorafenib, LGX818, RAF265, PLX.4720, SB.590885",0.0705810742857073,0,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",0.5534,1.58,0.0465,447,0.707,"apatinib, cabozantinib, regorafenib, sunitinib",1.33254704711005,0.150580586203101,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.56382,-1.9,0.00571,1308,0.138,"LE.135, AM.580, CD.437",2.24336389175415,0.860120913598763,TRUE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",0.23674,0.674,0.861,619,0.899,"triapine, hydroxyurea, gemcitabine, cladribine",0.0649968485463452,0.0462403082667712,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",0.38478,1.09,0.347,468,0.675,"paliperidone, lurasidone, tropisetron, RS.16566, lerisetron, SB.228357",0.459670525209126,0.170696227168975,FALSE
+"H460","Pearson.est","sodium channel blocker",0.3638,1.04,0.411,365,0.715,"oxcarbazepine, ajmaline, mexiletine, triamterene, butamben, mepivacaine",0.386158178123931,0.145693958198919,FALSE
+"H460","Pearson.est","src inhibitor",0.32925,0.944,0.512,799,0.809,"dasatinib, saracatinib, bosutinib, PP.2, masitinib, PP.1, ZM.306416, KX2.391",0.290730039024169,0.0920514783877277,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",0.50559,1.43,0.104,159,0.591,"LY2109761, repsox, adaprev",0.98296666070122,0.228412519118745,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",0.50207,1.43,0.0983,633,0.591,"capecitabine, raltitrexed, trifluridine, ftorafur, carmofur",1.00744648216786,0.228412519118745,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",0.3109,0.895,0.594,594,0.771,"camptothecin, etoposide, fleroxacin, valrubicin, idarubicin, TAS.103, teniposide, amsacrine, SN.38, voreloxin, genz.644282, amonafide",0.226213555018806,0.112945621949043,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.32028,-1.06,0.356,639,0.977,"epothilone.d, flubendazole, CYT.997, dolastatin.10, KX2.391, parbendazole, nocodazole, epothilone.b, plinabulin, docetaxel, ABT.751, podophyllotoxin, paclitaxel, combretastatin.A.4, verubulin, BNC105, fosbretabulin, vincristine, albendazole, indibulin, taltobulin, vindesine, vinblastine, vinorelbine, fenbendazole",0.448550002027125,0.0101054362812269,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",0.40625,1.16,0.281,447,0.592,"dasatinib, apatinib, cabozantinib, AMG.208, UNC2250, NVP.TAE226, mubritinib, regorafenib, sunitinib",0.55129368009492,0.22767829327708,FALSE
+"H460","Pearson.est","VEGFR inhibitor",0.3012,0.862,0.62,447,0.776,"cabozantinib, tivozanib, ENMD.2076, MK.2461, foretinib, KI.8751, PD.173074, OSI.930, XL.647, motesanib, nintedanib, regorafenib, MGCD.265, sunitinib",0.207608310501746,0.110138278741812,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",0.44152,1.25,0.194,771,0.592,"tacalcitol, maxacalcitol, alfacalcidol, ercalcitriol, paricalcitol, doxercalciferol, calcitriol",0.712198270069774,0.22767829327708,FALSE
+"H520","Pearson.est","EGFR inhibitor",0.50425,1.36,0.15,434,0.392,"WZ.3146, lapatinib, tucatinib, tyrphostin.AG.494, osimertinib, brigatinib, WZ8040, CGP.52411, PD.168393, BMS.599626, pelitinib, icotinib, CUDC.101, XL.647, poziotinib, canertinib, PD.153035, AZD8931, erlotinib, gefitinib, vandetanib, dacomitinib",0.823908740944319,0.406713932979543,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",-0.25796,-0.706,0.816,1216,0.99,"KW.2449, GZD824, tozasertib",0.0883098412461389,0.00436480540245009,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",0.34805,0.963,0.478,146,0.719,"nicotine, nefiracetam",0.320572103387881,0.143271109617117,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",0.64941,1.77,0.0371,507,0.202,"dicycloverine, iododexetimide, darifenacin, diphemanil, hyoscyamine, methscopolamine",1.43062609038495,0.694648630553376,TRUE
+"H520","Pearson.est","adenosine receptor antagonist",0.64709,1.78,0.0147,479,0.232,"CGS.15943, MRS.1220, theophylline, PSB.1115, sulmazole, istradefylline",1.83268266525182,0.6345120151091,TRUE
+"H520","Pearson.est","adrenergic receptor agonist",0.52221,1.44,0.118,244,0.318,"isoxsuprine, isoetharine, methyldopa, metaraminol, buphenine, terbutaline, ritodrine",0.928117992693875,0.497572880015567,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",0.3148,0.864,0.607,283,0.779,"atenolol...., prazosin, imiloxan, RS.17053, metoprolol, pindolol",0.216811308924742,0.108462542327436,FALSE
+"H520","Pearson.est","AKT inhibitor",0.40578,1.07,0.391,412,0.671,"GSK2110183, AT7867, GDC.0068, palomid.529, AZD5363, CCT128930",0.407823242604133,0.173277479831008,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27958,-0.747,0.764,1141,1,"SB.505124, NVP.TAE684, lorlatinib",0.11690664142431,0,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.662,1.78,0.0271,418,0.232,"RU.58841, cyproterone.acetate, enzalutamide, flutamide, nilutamide",1.56703070912559,0.6345120151091,TRUE
+"H520","Pearson.est","antioxidant",-0.3454,-0.934,0.521,1262,0.85,"mesna, chlorogenic.acid",0.283162276700476,0.0705810742857073,FALSE
+"H520","Pearson.est","AP inhibitor",0.54622,1.45,0.127,361,0.326,"embelin, tanshinone.i, idronoxil, GDC.0152",0.896196279044043,0.486782399932061,FALSE
+"H520","Pearson.est","ATPase inhibitor",-0.31517,-0.845,0.63,1074,0.906,"evodiamine, digoxin, thonzonium, NMS.873",0.200659450546418,0.0428718023231869,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.62188,-1.65,0.0468,1088,0.25,"MK.8745, TAK.901, alisertib, CCT129202, CCT137690, KW.2449, MK.5108, PHA.680632, PF.03814735, aurora.a.inhibitor.i, danusertib, GSK1070916, hesperadin, tozasertib, MLN.8054, barasertib",1.32975414692588,0.602059991327962,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54204,-1.44,0.114,1042,0.305,"radezolid, azalomycin.b, tedizolid, azithromycin, valnemulin",0.943095148663527,0.515700160653214,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",-0.25104,-0.681,0.831,1225,0.989,"novobiocin, trovafloxacin",0.080398976215889,0.0048037084028206,FALSE
+"H520","Pearson.est","BCL inhibitor",0.2426,0.665,0.877,39,0.981,"gossypol",0.0570004066339595,0.0083309926200515,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.27086,-0.746,0.769,1290,1,"GZD824, tozasertib",0.114073660198569,0,FALSE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.38213,1.06,0.354,229,0.663,"CL.218872, nefiracetam, gamma.aminobutyric.acid, ivermectin",0.450996737974212,0.178486471595227,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.76421,-2,0.00205,1235,0.0479,"OTX015, PFI.1, I.BET151, I.BET.762",2.68824613894425,1.31966448658544,TRUE
+"H520","Pearson.est","calcium channel blocker",0.21404,0.577,0.94,1130,0.979,"mibefradil, cinnarazine, efonidipine.monoethanolate, pranidipine, SR.33805, SKF.96365, fendiline, penfluridol, tetrandrine, carboxyamidotriazole",0.0268721464003014,0.00921730819686218,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",-0.48319,-1.33,0.158,1057,0.387,"ZK811752, PF.04136309, SB.225002, MK.0812",0.801342913045577,0.412289034981089,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.4988,-1.34,0.154,1351,0.403,"PHA.793887, R547, indisulam, BMS.265246, AZD5438",0.812479279163537,0.39469495385889,FALSE
+"H520","Pearson.est","CHK inhibitor",0.53642,1.47,0.0936,24,0.325,"SCH.900776",1.02872415126189,0.488116639021126,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",-0.15828,-0.423,0.99,1244,0.996,"indoprofen, sulfasalazine, AM.404",0.00436480540245009,0.00174066157630127,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.5525,1.48,0.0982,362,0.335,"clotrimazole, eplerenone, morin, metyrapone, cobicistat",1.00788851221305,0.474955192963155,FALSE
+"H520","Pearson.est","DNA alkylating agent",-0.21496,-0.579,0.926,1238,0.965,"mitomycin.c, carmustine",0.0333890133180656,0.0154726866562074,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.2491,-0.665,0.845,876,0.942,"teroxirone, mechlorethamine, busulfan, carboplatin, oxaliplatin, valrubicin, sangivamycin, carmustine",0.0731432910503077,0.0259490972071227,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.26032,-0.708,0.793,944,1,"azacitidine, decitabine, disulfiram, SGI.1027",0.100726812682396,0,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",-0.34041,-0.904,0.525,1077,0.83,"foscarnet, idoxuridine, cephalomannine, cidofovir",0.279840696594043,0.0809219076239261,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.40324,-1.08,0.356,1238,0.643,"mitomycin.c, enocitabine, anisomycin, capecitabine",0.448550002027125,0.191789027075778,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",0.32001,0.878,0.595,513,0.8,"ziprasidone, remoxipride, piperacetazine, sertindole, clebopride, lurasidone, mesoridazine, UH.232...., nemonapride, isofloxythepin",0.22548303427145,0.0969100130080564,FALSE
+"H520","Pearson.est","estrogen receptor agonist",0.42255,1.14,0.289,15,0.575,"levonorgestrel",0.539102157243452,0.24033215531037,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",0.374,1.03,0.411,336,0.644,"clomifene, tamoxifen, raloxifene",0.386158178123931,0.191114132640188,FALSE
+"H520","Pearson.est","FGFR inhibitor",0.43655,1.19,0.239,384,0.52,"lucitanib, PD.173074, orantinib, regorafenib, erdafitinib",0.621602099051862,0.283996656365201,FALSE
+"H520","Pearson.est","FLT3 inhibitor",0.24132,0.653,0.868,140,0.973,"tandutinib, GTP.14564, midostaurin",0.0614802748235081,0.0118871597316481,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",-0.48744,-1.31,0.183,1002,0.386,"fludroxycortide, fluticasone.propionate, triamcinolone.acetonide, deflazacort, clobetasol.propionate, flumethasone.pivalate, betamethasone, halcinonide, halobetasol.propionate, beclomethasone.dipropionate, rimexolone, fluorometholone",0.737548910269571,0.413412695328245,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",0.44626,1.21,0.247,224,0.512,"SIB.1757, ACDPP, JNJ.16259685, kynurenic.acid, diazooxonorleucine",0.607303046740334,0.290730039024169,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.6047,1.65,0.0402,97,0.288,"TWS.119, indirubin, GSK.3.inhibitor.IX",1.39577394691553,0.540607512240769,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",0.33456,0.901,0.541,135,0.784,"GW.441756, GSK1838705A",0.266802734893431,0.105683937315562,FALSE
+"H520","Pearson.est","HDAC inhibitor",-0.61829,-1.64,0.0451,1105,0.225,"vorinostat, ACY.1215, entinostat, NSC.3852, resminostat, chidamide, PCI.24781, panobinostat, scriptaid, belinostat, SB.939, trichostatin.a, AR.42, givinostat, JNJ.26481585, romidepsin, dacinostat, M.344",1.34582345812204,0.647817481888638,TRUE
+"H520","Pearson.est","histamine receptor antagonist",0.2337,0.633,0.861,118,0.973,"terfenadine, chloropyramine, famotidine",0.0649968485463452,0.0118871597316481,FALSE
+"H520","Pearson.est","HSP inhibitor",-0.68719,-1.85,0.00967,1224,0.111,"alvespimycin, PU.H71, ganetespib, KW.2478, BIIB021, NMS.E973, VER.49009, tanespimycin, SNX.2112",2.014573525917,0.954677021213343,TRUE
+"H520","Pearson.est","JAK inhibitor",0.32204,0.86,0.619,233,0.765,"baricitinib, atiprimod, AT.9283, ruxolitinib, LY2784544",0.208309350979882,0.116338564846382,FALSE
+"H520","Pearson.est","KIT inhibitor",0.35763,0.96,0.498,205,0.702,"tandutinib, dasatinib, midostaurin, masitinib, telatinib, imatinib",0.302770657240282,0.153662887870195,FALSE
+"H520","Pearson.est","MDM inhibitor",0.58642,1.58,0.0621,597,0.314,"AMG.232, RITA, CGM097, idasanutlin, nutlin.3, serdemetan",1.20690839982342,0.503070351926785,FALSE
+"H520","Pearson.est","MEK inhibitor",-0.59363,-1.56,0.0711,1277,0.285,"PD.98059, PD.318088, PD.184352, PD.0325901, TAK.733, AZD8330, MEK162, Ro.4987655, refametinib, PD.198306",1.14813039927023,0.54515513999149,FALSE
+"H520","Pearson.est","MET inhibitor",0.64528,1.78,0.0264,435,0.232,"NVP.BVU972, PF.04217903, INC.280, LY2801653, PHA.665752",1.57839607313017,0.6345120151091,TRUE
+"H520","Pearson.est","microtubule inhibitor",0.2976,0.822,0.656,212,0.789,"colchicine, estramustine.phosphate, secnidazole",0.18309616062434,0.10292299679058,FALSE
+"H520","Pearson.est","mTOR inhibitor",0.57334,1.54,0.0795,471,0.285,"torin.1, PI.103, SB.2343, sirolimus, LY3023414, deforolimus, torin.2, WAY.600, OSI.027, PF.04691502, everolimus, ku.0063794, temsirolimus, palomid.529, WYE.125132, AZD8055, NVP.BEZ235, PP242, GDC.0980",1.09963287134353,0.54515513999149,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",-0.34911,-0.913,0.514,1102,0.852,"BAY.11.7085, Ro.106.9920, parthenolide...., EVP4593",0.289036881004724,0.0695604052332999,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.3898,1.04,0.404,332,0.649,"cebranopadol, ADL5859, trimebutine",0.393618634889395,0.187755303199631,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",0.64458,1.74,0.0333,437,0.205,"SB.242235, TAK.715, SB.239063, skepinone.l, VX.702",1.47755576649368,0.688246138944246,TRUE
+"H520","Pearson.est","PARP inhibitor",-0.43612,-1.15,0.298,1099,0.59,"endo.IWR.1, AG.14361, talazoparib, olaparib",0.525783735923745,0.229147988357856,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.32762,0.873,0.604,280,0.787,"tandutinib, dasatinib, SU014813, masitinib, telatinib, imatinib, orantinib, regorafenib",0.218963061378868,0.104025267640935,FALSE
+"H520","Pearson.est","phosphatase inhibitor",0.56727,1.56,0.0693,407,0.284,"menadione, AS.1949490, mycophenolic.acid, BVT.948, mycophenolate.mofetil, alexidine",1.15926676538819,0.546681659952962,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",0.4956,1.33,0.154,318,0.409,"GSK256066, avanafil, enoximone, cilostamide",0.812479279163537,0.388276691992658,FALSE
+"H520","Pearson.est","PI3K inhibitor",0.30378,0.824,0.649,167,0.806,"PI.103, SB.2343, TG100.115, LY3023414, PF.04691502",0.187755303199631,0.0936649581949093,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.86557,-2.32,0,1289,0.00476,"volasertib, NMS.1286937, GW.843682X, GSK461364, rigosertib, BI.2536",Inf,2.32239304727951,TRUE
+"H520","Pearson.est","potassium channel blocker",-0.55153,-1.47,0.101,1411,0.3,"dofetilide",0.995678626217357,0.522878745280338,FALSE
+"H520","Pearson.est","PPAR receptor agonist",0.60406,1.59,0.0598,156,0.336,"pterostilbene, S26948, GW.501516",1.22329881601159,0.473660722610156,FALSE
+"H520","Pearson.est","progesterone receptor agonist",0.68736,1.87,0.00982,26,0.673,"norethindrone.acetate, levonorgestrel, nomegestrol.acetate",2.00788851221305,0.171984935776023,FALSE
+"H520","Pearson.est","proteasome inhibitor",-0.75661,-2.01,0.00397,1108,0.0658,"oprozomib, delanzomib, ixazomib, ONX.0914, carfilzomib",2.40120949323688,1.18177410638604,TRUE
+"H520","Pearson.est","protein synthesis inhibitor",-0.41425,-1.11,0.307,1109,0.624,"anguidine, thiostrepton, harringtonine, puromycin, azomycin..2.nitroimidazole., cycloheximide, bruceantin, tedizolid.phosphate",0.512861624522813,0.204815410317576,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",0.22801,0.616,0.895,210,0.967,"mubritinib, BMS.599626",0.048176964684088,0.0145735259169983,FALSE
+"H520","Pearson.est","RAF inhibitor",-0.57183,-1.53,0.0765,967,0.259,"AZ.628, GDC.0879, vemurafenib, dabrafenib, RAF265, SB.590885, PLX.4720, CEP.32496, TAK.632, sorafenib",1.11633856484638,0.586700235918748,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.38152,-1.02,0.433,1420,0.716,"sorafenib",0.363512103646635,0.145086977692144,FALSE
+"H520","Pearson.est","retinoid receptor agonist",0.28575,0.788,0.708,441,0.824,"fenretinide, CD.437, bexarotene, tamibarotene",0.149966742310231,0.0840727883028842,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",0.45577,1.23,0.222,402,0.505,"triapine, cladribine, cytarabine, pentostatin, gemcitabine",0.653647025549361,0.296708621881339,FALSE
+"H520","Pearson.est","serotonin receptor antagonist",-0.25005,-0.671,0.848,1089,0.968,"SB.228357, pirenperone, SB.200646, paliperidone, tropisetron",0.0716041477432862,0.0141246426916063,FALSE
+"H520","Pearson.est","sodium channel blocker",0.20745,0.569,0.941,1140,0.963,"A.803467, benzocaine, oxcarbazepine, ajmaline, cibenzoline, brivaracetam, butamben, quinidine, triamterene, mepivacaine, lappaconite, mexiletine, benzethonium",0.0264103765727431,0.0163737128754655,FALSE
+"H520","Pearson.est","src inhibitor",0.59563,1.57,0.0708,185,0.297,"dasatinib, saracatinib, masitinib, PP.2",1.14996674231023,0.527243550682788,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",0.49154,1.31,0.172,460,0.412,"terconazole, posaconazole, sulconazole, lanoconazole",0.764471553092451,0.385102783966865,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",0.69526,1.86,0.00826,154,0.361,"SB.525334, LY2109761",2.08301995267962,0.442492798094342,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",0.37096,0.998,0.439,172,0.68,"ftorafur, doxifluridine",0.357535479757879,0.167491087293764,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",-0.66722,-1.83,0.00774,1018,0.1,"amonafide, licochalcone.a, etoposide.phosphate, valrubicin, voreloxin, nemorubicin, teniposide, genz.644282, etoposide, epirubicin, TAS.103, irinotecan, camptothecin, daunorubicin, rubitecan, amsacrine, idarubicin, mitoxantrone, doxorubicin, topotecan, dexrazoxane",2.11125903931711,1,TRUE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.5495,-1.53,0.0877,997,0.259,"KX2.391, plinabulin, BNC105, ABT.751, taltobulin, vinblastine, dolastatin.10, combretastatin.A.4, parbendazole, vincristine, epothilone.b, vindesine, vinorelbine, fosbretabulin, docetaxel, paclitaxel, fenbendazole",1.05700040663396,0.586700235918748,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",-0.22073,-0.594,0.929,1350,0.984,"tivantinib, PP.121, sorafenib",0.0319842860063582,0.00700490156865849,FALSE
+"H520","Pearson.est","VEGFR inhibitor",0.1907,0.508,0.98,485,0.975,"lucitanib, SU014813, PD.173074, telatinib, foretinib, semaxanib, orantinib, regorafenib, XL.647, golvatinib, linifanib, SAR131675, vandetanib, KI.8751, sunitinib, BMS.690514",0.00877392430750515,0.0109953843014632,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",0.38851,1.04,0.384,627,0.649,"doxercalciferol, ercalcitriol, maxacalcitol, tacalcitol, alfacalcidol, paricalcitol",0.415668775632469,0.187755303199631,FALSE
diff --git a/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren.prot/DMEA/DMEA_venn_diagram.pdf
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diff --git a/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_interactive_network.graph.html b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_interactive_network.graph.html
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--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-beeac02d71a0843f7db4" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_mean_results.csv
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@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"estrogen receptor antagonist",1.00241666666667,0.696588891192885,0.124327712710528,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.265331768848105
+"RAF inhibitor",0.698,1.13162080060577,0.0047006947780887,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0278684047558116
+"MEK inhibitor",0.667833333333333,1.60164357817685,5.08540197049992e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"H1650, H520, H460, H1299, H1703",0.000844176727102987
+"retinoid receptor agonist",0.610333333333333,1.03738520357968,0.171997633009449,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.339900084280579
+"HMGCR inhibitor",0.5195,1.9209607681385,8.5331314142516e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"HCC95, H1975, H1648, H2126, H1299, HCC44, H1703",0.000395749475218249
+"MDM inhibitor",0.45425,1.52040958147946,0.00416580339781743,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, HCC95, H1648, H460",0.0265970524629882
+"glutamate receptor antagonist",0.43275,0.716226237111761,0.987358742586612,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"BCL inhibitor",0.425416666666667,1.05488159252232,0.304199929869937,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.515277432228669
+"dopamine receptor antagonist",0.4205,0.89417046371585,0.875993102824703,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"RET tyrosine kinase inhibitor",0.406416666666667,1.0790967989551,0.291163973828253,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50697819475302
+"phosphatase inhibitor",0.393166666666667,0.983230744520175,0.513890846378439,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.804772457536046
+"thymidylate synthase inhibitor",0.353416666666667,1.40048059662216,4.67424917816275e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H2126, HCC44",0.000844176727102987
+"FGFR inhibitor",0.32725,1.13192427669956,0.176518018039236,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.340720825517595
+"benzodiazepine receptor agonist",0.32275,0.573400562037965,0.999999744255947,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"Bcr.Abl kinase inhibitor",0.311416666666667,1.25046772764386,0.0259847661335041,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.0937711125687321
+"antioxidant",0.2925,1.39479633573573,0.0129712791125946,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.0616112951911576
+"Abl kinase inhibitor",0.2875,1.24619431579801,0.041043726324705,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.121665331605376
+"acetylcholine receptor agonist",0.236583333333333,0.981314559736844,0.770707396593526,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"cytochrome P450 inhibitor",0.232083333333333,1.30142770960716,0.0150124187360823,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.0655805660576229
+"proteasome inhibitor",0.221916666666667,1.25182531879966,0.0251527702555807,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0937711125687321
+"CC chemokine receptor antagonist",0.215916666666667,1.30495743283647,0.00678708773166565,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0375552187818833
+"p38 MAPK inhibitor",0.213916666666667,1.20391123640886,0.094665808369185,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.218257280406732
+"adenosine receptor antagonist",0.185,1.38904735176831,0.00218259813041714,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H2126, H1299, H1703",0.0164686949840566
+"TGF beta receptor inhibitor",0.164,1.2726662063272,0.0381301100288775,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.117214782681364
+"adrenergic receptor agonist",0.142583333333333,0.841425031320874,0.992401426537453,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"FLT3 inhibitor",0.13425,1.09332463157106,0.410067230754878,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.667364316718723
+"bacterial DNA gyrase inhibitor",0.13425,1.03675017811341,0.684040247241143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.946255675350247
+"HCV inhibitor",0.126916666666667,1.05333370852506,0.633163264300218,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"sterol demethylase inhibitor",0.125583333333333,0.99504037911062,0.792730624396318,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"histamine receptor antagonist",0.113166666666667,0.67722251390022,0.999997961805646,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"growth factor receptor inhibitor",0.10475,1.26224044136535,0.0379479136146386,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.117214782681364
+"ALK tyrosine kinase receptor inhibitor",0.0668333333333333,1.01703542740952,0.741185677459224,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.999999744255948
+"EGFR inhibitor",0.058,1.84339055201895,3.20369112697271e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"HCC95, H1975, H1648, H2126, H520, H1299, H1703",0.000844176727102987
+"mTOR inhibitor",0.0465833333333333,1.05096738625406,0.614580823363627,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"glycogen synthase kinase inhibitor",0.0435,0.980106534098114,0.998823553215968,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.999999744255948
+"bromodomain inhibitor",0.04025,1.53547914493993,0.0340763504946138,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, A549",0.113133483642118
+"glucocorticoid receptor agonist",0.0339166666666667,1.29597309584401,0.0158476448165722,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0657677259887745
+"src inhibitor",0.0273333333333334,1.50636403503954,8.24951913546827e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"HCC95, H520, H1299, HCC44, H1703",0.00114118348040644
+"KIT inhibitor",0.0248333333333333,0.94747125965846,0.935832669479616,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"HDAC inhibitor",0.0211666666666666,1.1537745039914,0.293192209013795,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, A549",0.50697819475302
+"acetylcholine receptor antagonist",-0.00183333333333337,1.23950597441322,0.0779561053013444,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.200456681429326
+"estrogen receptor agonist",-0.00725000000000005,0.801671336532735,0.999452080686153,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"DNA inhibitor",-0.00916666666666668,0.931550694793202,0.966638581217711,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"progesterone receptor agonist",-0.0171666666666666,1.09721745862666,0.46373187184175,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.740187410824331
+"PI3K inhibitor",-0.0253333333333333,1.06693608339985,0.608568603424358,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"tyrosine kinase inhibitor",-0.02975,1.00830380748156,0.811127303266585,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"DNA polymerase inhibitor",-0.0300833333333334,1.04827507305472,0.588924130380289,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"DNA methyltransferase inhibitor",-0.0356666666666666,1.13077329400028,0.283229556884785,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50697819475302
+"ribonucleotide reductase inhibitor",-0.0415000000000001,1.28968385837206,0.0329390189674143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.113133483642118
+"opioid receptor agonist",-0.0475833333333333,1.23267303475255,0.0933508384303763,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.218257280406732
+"AP inhibitor",-0.0699166666666666,1.33192556837722,0.101268730435768,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, A549",0.227170395301859
+"PPAR receptor agonist",-0.0780833333333334,1.27135793245814,0.0627046999800293,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.167886777365885
+"NFkB pathway inhibitor",-0.0893333333333333,0.704062669386925,0.99998542119808,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"JAK inhibitor",-0.0970833333333334,1.01858515583969,0.812129700429645,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"AKT inhibitor",-0.119916666666667,1.24744243505978,0.0796996444237081,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.200456681429326
+"phosphodiesterase inhibitor",-0.125833333333333,0.938912313974704,0.926782184949637,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"PDGFR tyrosine kinase receptor inhibitor",-0.1285,1.00276857658276,0.762426676890818,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"protein tyrosine kinase inhibitor",-0.166416666666667,1.3955663860522,0.000996752902459099,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H1648, H2126",0.0103413113630132
+"CDK inhibitor",-0.201916666666667,1.16107743523249,0.0941930017532901,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.218257280406732
+"CHK inhibitor",-0.209583333333333,1.18310919025279,0.204180911811555,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.385159447280888
+"protein synthesis inhibitor",-0.248833333333333,1.17580137726909,0.140001294478339,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.290502686042554
+"serotonin receptor antagonist",-0.263916666666667,1.03078244405388,0.624882064154891,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"VEGFR inhibitor",-0.2715,0.741741868846568,0.999534634664959,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"calcium channel blocker",-0.27525,0.937528775315966,0.866095767459057,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"adrenergic receptor antagonist",-0.275916666666667,0.770525494632584,0.998631425519013,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"androgen receptor antagonist",-0.29825,1.28566609018615,0.0133614857041065,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, A549, HCC15",0.0616112951911576
+"bacterial 50S ribosomal subunit inhibitor",-0.31975,0.987198158702423,0.630216737456706,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"Aurora kinase inhibitor",-0.37975,1.24472122654761,0.0085197872386698,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0441963963005996
+"PARP inhibitor",-0.394416666666667,1.1955539954601,0.044614158385556,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.127688798137971
+"DNA alkylating agent",-0.401166666666667,0.901674486046865,0.846215198379105,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"potassium channel blocker",-0.408,1.0340825534128,0.399605399146996,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.663344962584014
+"sodium channel blocker",-0.409833333333333,0.682226013380708,0.998626395757675,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"DNA synthesis inhibitor",-0.438166666666667,1.10393995499865,0.226980227883247,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.41865242031799
+"vitamin D receptor agonist",-0.442416666666667,1.55978701683236,0.0206707016748029,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H2126, H1299",0.08169848757184
+"MET inhibitor",-0.4645,1.14146233960095,0.165128270570095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.334284059934583
+"cyclooxygenase inhibitor",-0.46875,0.609628370402822,0.999158830773346,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"tubulin polymerization inhibitor",-0.49775,1.28656894844035,0.00133279142519831,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H2126, H1299",0.012291298699051
+"PLK inhibitor",-0.596666666666667,1.47931392779548,9.53613193296986e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H460, H1299",0.000395749475218249
+"microtubule inhibitor",-0.613833333333333,1.17771124978867,0.00249951164829279,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H2126, H460, H1299",0.0172882889006918
+"topoisomerase inhibitor",-0.66875,1.22133058029497,0.00183574463749805,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1299, H1703",0.0152366804912338
+"ATPase inhibitor",-0.752666666666667,1.00384717537838,0.0468005257141872,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.129481454475918
+"serotonin receptor agonist",-0.81,1.27959148310559,0.00014168317666895,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.00167995766621755
+"HSP inhibitor",-0.958416666666667,0.69444293676604,0.124673963675616,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265331768848105
diff --git a/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..6cd3803
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_results.csv
@@ -0,0 +1,997 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H1650","Pearson.est","EGFR inhibitor",-0.18808,-0.582,0.967,1165,0.95,"AZD8931, TAK.285, FERb.033, WZ8040, icotinib, WZ.3146, BMS.599626, neratinib, rociletinib, ARRY.334543, CP.724714, lapatinib, osimertinib, PD.168393, GW.583340, brigatinib, canertinib, BMS.690514, tucatinib",0.0145735259169983,0.0222763947111523,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",0.54126,1.27,0.168,427,0.685,"KW.2449, GZD824, tozasertib, bafetinib, ponatinib, nilotinib, flumatinib",0.774690718274137,0.164309428507574,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.55053,1.31,0.143,550,0.745,"oxiracetam, tremorine, pilocarpine, xanomeline, nicotine",0.844663962534938,0.127843727251707,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.52982,-1.61,0.0464,764,0.393,"hyoscyamine, iododexetimide, dicycloverine, diphemanil, methscopolamine, darifenacin",1.33348201944512,0.405607449624573,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",0.45164,1.08,0.365,328,0.885,"istradefylline, sulmazole, PSB.1115, SCH.58261",0.437707135543525,0.0530567293021746,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.19853,-0.624,0.915,1447,0.978,"xylazine",0.0385789059335517,0.00966114521239857,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.34548,0.829,0.694,317,1,"oxprenolol, carvedilol, atipamezole, atenolol......, idazoxan",0.158640529545145,0,FALSE
+"H1650","Pearson.est","AKT inhibitor",-0.31037,-0.9,0.587,446,0.645,"palomid.529, ONC201, uprosertib, AT7867, AZD5363, MK.2206, triciribine, GSK2110183, CCT128930, A.674563, GDC.0068",0.231361898752386,0.190440285364732,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39974,0.947,0.545,510,0.988,"AZD3463, alectinib, DMH1, lorlatinib, CEP.37440",0.263603497723358,0.00524305541237188,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.35563,-1.06,0.35,1234,0.475,"enzalutamide, flutamide, RU.58841",0.455931955649724,0.323306390375133,FALSE
+"H1650","Pearson.est","antioxidant",0.45589,1.07,0.398,231,0.854,"mesna, trolox",0.400116927926312,0.068542129310995,FALSE
+"H1650","Pearson.est","AP inhibitor",-0.45002,-1.36,0.109,1216,0.526,"LCL.161, tanshinone.i, birinapant, GDC.0152",0.962573502059376,0.279014255846261,FALSE
+"H1650","Pearson.est","ATPase inhibitor",-0.44453,-1.42,0.109,1318,0.559,"rabeprazole, digitoxigenin, oligomycin.a, omeprazole, k.strophanthidin",0.962573502059376,0.252588192113577,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.56442,1.33,0.124,533,0.729,"GSK1070916, SNS.314, KW.2449, tozasertib, AT.9283, danusertib, hesperadin, alisertib, CCT129202, AMG900, barasertib, barasertib.HQPA, ENMD.2076, CCT137690, PHA.680632, PF.03814735, MK.8745, MK.5108",0.906578314837765,0.137272471682025,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30728,0.734,0.824,684,1,"valnemulin, tedizolid, tilmicosin, azalomycin.b, azithromycin",0.0840727883028842,0,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.53356,1.27,0.178,146,0.685,"finafloxacin, novobiocin",0.749579997691106,0.164309428507574,FALSE
+"H1650","Pearson.est","BCL inhibitor",0.51208,1.23,0.202,224,0.693,"gossypol, TW.37, obatoclax",0.694648630553376,0.159266765388193,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.51671,1.23,0.209,427,0.693,"GZD824, tozasertib, bafetinib, ponatinib, nilotinib, flumatinib",0.679853713888946,0.159266765388193,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",0.17413,0.42,0.991,706,0.995,"zaleplon, ZK.93423, lorazepam, ivermectin, eprinomectin, temazepam",0.00392634551472468,0.00217691925427455,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.49653,1.21,0.228,732,0.686,"bromosporine, I.BET.762, JQ1...., PFI.1, I.BET151, OTX015",0.642065152999546,0.163675884293248,FALSE
+"H1650","Pearson.est","calcium channel blocker",0.33933,0.813,0.723,342,1,"tetrandrine, cinnarazine, mibefradil",0.140861702705469,0,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",0.70818,1.69,0.0131,233,0.17,"navarixin, ZK811752, PF.04136309, SB.225002",1.88272870434424,0.769551078621726,TRUE
+"H1650","Pearson.est","CDK inhibitor",0.69186,1.64,0.0126,248,0.214,"palbociclib, AZD5438, ribociclib, indisulam, abemaciclib, alvocidib, PHA.848125, JNJ.7706621, TG.02, aminopurvalanol.a, dinaciclib, P276.00",1.89962945488244,0.669586226650809,TRUE
+"H1650","Pearson.est","CHK inhibitor",-0.43234,-1.3,0.196,623,0.514,"SB.218078, AZD7762, CHIR.124, LY2606368, SCH.900776, LY2603618, PF.477736",0.707743928643524,0.289036881004724,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",0.2703,0.644,0.904,453,1,"tepoxalin, meloxicam, FR.122047, ketoprofen, curcumin, aspirin, piroxicam, indoprofen",0.0438315695246367,0,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",0.44419,1.05,0.399,486,0.854,"morin, itraconazole, cobicistat",0.399027104313252,0.068542129310995,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.43944,1.04,0.411,482,0.854,"carmustine, melphalan, cyclophosphamide, carboplatin, temozolomide, TH.302, streptozotocin",0.386158178123931,0.068542129310995,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.39707,0.941,0.549,395,0.976,"carmustine, oxaliplatin, melphalan, carboplatin, mechlorethamine, sangivamycin, bendamustine",0.260427655549908,0.0105501823333082,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.27229,0.654,0.901,653,1,"fdcyd, disulfiram, decitabine, RG108",0.045275209020937,0,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",0.47391,1.13,0.323,457,0.77,"idoxuridine, trifluridine, adefovir.dipivoxil, foscarnet, famciclovir",0.490797477668897,0.113509274827518,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",0.44794,1.07,0.392,226,0.854,"anisomycin, floxuridine, cyclocytidine, CB.10.277",0.406713932979543,0.068542129310995,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",0.46674,1.13,0.311,280,0.77,"domperidone, amisulpride, UH.232...., sertindole, paliperidone, isofloxythepin, mesoridazine",0.507239610973163,0.113509274827518,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",0.30122,0.715,0.842,481,1,"PPT, estrone, erteberel, ethinyl.estradiol",0.0746879085003505,0,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",0.52217,1.22,0.218,456,0.689,"raloxifene, clomifene, fulvestrant",0.661543506395395,0.161780778092374,FALSE
+"H1650","Pearson.est","FGFR inhibitor",0.38321,0.91,0.587,378,0.975,"regorafenib, PD.173074, dovitinib",0.231361898752386,0.0109953843014632,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.57249,1.36,0.113,436,0.838,"gilteritinib, KW.2449, tozasertib, ponatinib, TG.02, pacritinib, lestaurtinib, TG.101348, ENMD.2076, dovitinib, sunitinib",0.94692155651658,0.0767559813697235,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",0.55703,1.34,0.137,407,0.758,"hydrocortisone, prednisolone, ciclesonide, fluocinolone.acetonide, triamcinolone.acetonide, rimexolone, halobetasol.propionate, difluprednate, methylprednisolone, desonide, fluticasone.propionate, flumethasone.pivalate, halcinonide, triamcinolone, prednisolone.acetate",0.863279432843593,0.120330794367946,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",0.29918,0.714,0.843,160,1,"diazooxonorleucine, SIB.1757",0.0741724253752577,0,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.3524,0.848,0.669,615,1,"tideglusib, TWS.119, CHIR.99021, kenpaullone, AZD2858",0.174573882232177,0,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.65866,1.57,0.0297,327,0.304,"GSK1838705A, AZD3463, PHA.848125, danusertib, lestaurtinib, GSK1904529A",1.52724355068279,0.517126416391246,FALSE
+"H1650","Pearson.est","HCV inhibitor",0.41615,0.992,0.493,600,0.927,"embelin, PSI.7976, mericitabine",0.30715308072277,0.0329202658555029,FALSE
+"H1650","Pearson.est","HDAC inhibitor",0.22243,0.543,0.952,555,1,"PCI.24781, givinostat, trichostatin.a, panobinostat, AR.42, resminostat, belinostat, entinostat, dacinostat, R306465",0.0213630516155257,0,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",0.2411,0.575,0.951,923,1,"pheniramine, astemizole, tiotidine, ranitidine, ICI.162846, epinastine, BF2.649, zolantidine, levocetirizine, famotidine, tecastemizole, cimetidine, nizatidine, cyproheptadine",0.0218194830625861,0,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.41401,-1.27,0.195,597,0.413,"lovastatin, simvastatin, atorvastatin, mevastatin, fluvastatin, pitavastatin",0.709965388637482,0.384049948343599,FALSE
+"H1650","Pearson.est","HSP inhibitor",-0.35367,-1.07,0.323,1294,0.502,"VER.49009, tanespimycin, guanidine, alvespimycin, KW.2478",0.490797477668897,0.299296282854981,FALSE
+"H1650","Pearson.est","JAK inhibitor",0.49631,1.18,0.27,431,0.713,"atiprimod, TG.101209, tozasertib, AZ960, TG.02, AT.9283, pacritinib, lestaurtinib, TG.101348, AZD1480, filgotinib",0.568636235841013,0.146910470148134,FALSE
+"H1650","Pearson.est","KIT inhibitor",0.39485,0.928,0.566,149,0.958,"KI.8751, regorafenib, OSI.930",0.247183568811729,0.0186344909214556,FALSE
+"H1650","Pearson.est","MDM inhibitor",0.82133,1.94,0,180,0.0323,"idasanutlin, nutlin.3, serdemetan, CGM097, AMG.232",Inf,1.4907974776689,TRUE
+"H1650","Pearson.est","MEK inhibitor",0.86838,2.1,0,96,0.00468,"cobimetinib, AZD8330, AS.703026, PD.0325901, trametinib, TAK.733, MEK162, Ro.4987655, selumetinib, PD.318088, refametinib, PD.198306, PD.184352",Inf,2.32975414692588,TRUE
+"H1650","Pearson.est","MET inhibitor",0.33916,0.808,0.71,678,1,"PHA.665752, LY2801653, AMG458",0.148741651280925,0,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.31595,0.756,0.796,608,1,"vinflunine, podophyllotoxin, vinblastine, D.64131, triclabendazole, secnidazole",0.0990869322623309,0,FALSE
+"H1650","Pearson.est","mTOR inhibitor",0.36306,0.853,0.689,463,1,"XL388, WAY.600, ku.0063794, LY303511, WYE.354, torin.1, PF.04691502, PP242, OSI.027, palomid.529, GSK2126458, voxtalisib, AZD8055",0.161780778092374,0,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",0.27807,0.663,0.89,621,1,"bortezomib, curcumin, betulinic.acid, parthenolide...., EVP4593, parthenolide",0.0506099933550872,0,FALSE
+"H1650","Pearson.est","opioid receptor agonist",0.49789,1.18,0.251,562,0.713,"trimebutine, salvinorin.a, cebranopadol",0.600326278518962,0.146910470148134,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.44356,1.06,0.401,696,0.854,"skepinone.l, SB.242235, VX.702, TAK.715, CMPD.1",0.396855627379818,0.068542129310995,FALSE
+"H1650","Pearson.est","PARP inhibitor",0.54492,1.29,0.159,333,0.707,"talazoparib, niraparib, AG.14361",0.798602875679548,0.150580586203101,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.23349,0.561,0.949,448,1,"KI.8751, regorafenib, ponatinib, dovitinib, sunitinib, crenolanib",0.0227337875727074,0,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",0.24877,0.592,0.941,225,1,"GSK2830371, sodium.stibogluconate",0.0264103765727431,0,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",-0.33171,-0.984,0.428,477,0.553,"avanafil, GSK256066, EMD.53998, anagrelide, zardaverine, cilostamide, YM.976, trequinsin, papaverine, enoximone",0.368556230986828,0.257274868695302,FALSE
+"H1650","Pearson.est","PI3K inhibitor",0.3958,0.931,0.564,503,0.975,"YM.201636, LY303511, buparlisib, PIK.75, ZSTK.474, GDC.0941, AZD6482, PF.04691502, GSK2126458, voxtalisib, TG.100713",0.248720896016658,0.0109953843014632,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.62742,1.48,0.0734,296,0.487,"rigosertib, NMS.1286937, volasertib, GSK461364",1.13430394008393,0.312471038785366,FALSE
+"H1650","Pearson.est","potassium channel blocker",-0.38488,-1.18,0.252,555,0.485,"meglitinide, oleoylethanolamide, ML133, ibutilide, mepivacaine, dofetilide",0.598599459218456,0.314258261397736,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",-0.38793,-1.15,0.265,559,0.477,"ciprofibrate, oleoylethanolamide, fenofibrate, clofibrate, S26948, pterostilbene, GW.501516",0.576754126063192,0.321481620959886,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",0.32588,0.774,0.755,426,1,"melengestrol.acetate, nomegestrol.acetate, tanaproget",0.122053048370812,0,FALSE
+"H1650","Pearson.est","proteasome inhibitor",0.20868,0.498,0.979,563,1,"bortezomib, ixazomib, MG.132",0.00921730819686218,0,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.41826,0.988,0.493,120,0.912,"brefeldin.a, cycloheximide, homoharringtonine",0.30715308072277,0.0400051616715838,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.29662,0.699,0.842,57,1,"NVP.TAE226",0.0746879085003505,0,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.74518,1.76,0.00585,144,0.106,"AZ.628, dabrafenib, CEP.32496, GDC.0879, LGX818, SB.590885, vemurafenib, regorafenib",2.23284413391782,0.97469413473523,TRUE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.48011,1.14,0.284,670,0.801,"regorafenib, sunitinib, sorafenib, vandetanib",0.546681659952962,0.0963674839157623,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.4206,1,0.482,281,0.933,"tamibarotene, CD.437, adarotene",0.31695296176115,0.0301183562535,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.54497,1.3,0.165,331,0.723,"LY2334737, triapine, clofarabine, fludarabine.phosphate, cladribine",0.782516055786094,0.140861702705469,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",0.28963,0.693,0.849,855,1,"NAN.190, ipsapirone, aripiprazole, SR.57227A, zolmitriptan",0.0710923097560473,0,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",0.55315,1.34,0.126,274,0.758,"pirenperone, sertindole, paliperidone, SB.216641, SB.200646, lerisetron",0.899629454882437,0.120330794367946,FALSE
+"H1650","Pearson.est","sodium channel blocker",0.32985,0.785,0.75,419,1,"ajmaline, mexiletine, benzethonium, quinidine, butamben",0.1249387366083,0,FALSE
+"H1650","Pearson.est","src inhibitor",0.27796,0.668,0.891,51,1,"PP.2",0.0501222959631252,0,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",-0.38003,-1.13,0.256,548,0.455,"terconazole, posaconazole, lanoconazole, ketoconazole, sulconazole, chlormidazole",0.59176003468815,0.341988603342888,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.42718,-1.28,0.155,616,0.464,"SB.525334, D.4476, adaprev, SB.431542, repsox, LY2109761",0.809668301829709,0.333482019445119,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.75588,1.79,0.0034,295,0.109,"carmofur, raltitrexed, trifluridine, ftorafur",2.46852108295775,0.962573502059376,TRUE
+"H1650","Pearson.est","topoisomerase inhibitor",0.38246,0.899,0.601,681,0.976,"amsacrine, topotecan, fleroxacin, idarubicin, voreloxin, teniposide, TAS.103, SN.38, exatecan.mesylate, rubitecan, daunorubicin, valrubicin, nemorubicin, doxorubicin, genz.644282, licochalcone.a",0.22112552799726,0.0105501823333082,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.52319,1.25,0.206,479,0.706,"verubulin, indibulin, albendazole, fosbretabulin, oxibendazole, parbendazole, podophyllotoxin, nocodazole, vindesine, vinorelbine, vinblastine, epothilone.b, BNC105, combretastatin.A.4, taltobulin, plinabulin, vincristine, dolastatin.10",0.686132779630847,0.151195298948196,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.31444,0.758,0.769,708,1,"NVP.TAE226, regorafenib, bafetinib, aminopurvalanol.a, tivantinib, UNC2250, sunitinib, tyrphostin.A9, PP.121, hypericin, sorafenib, vandetanib, dasatinib",0.114073660198569,0,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.19227,0.457,0.983,796,1,"KI.8751, regorafenib, OSI.930, PD.173074, ENMD.2076, TG.100572, dovitinib, sunitinib, RAF265, sorafenib, golvatinib, vandetanib, axitinib, semaxanib, MK.2461, SAR131675, orantinib, vatalanib, pazopanib",0.00744648216786438,0,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.51224,-1.63,0.0192,1326,0.725,"calcitriol, maxacalcitol",1.71669877129645,0.139661993429006,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",-0.82172,-2.01,0,1330,0.0316,"CNX.2006, CUDC.101, TAK.285, PD.168393, GW.583340, BMS.599626, WZ8040, brigatinib, AST.1306, WZ.3146, icotinib, WZ.4002, BIBX.1382, ARRY.334543, CP.724714, AEE788, pelitinib, BMS.690514, tucatinib, rociletinib, lapatinib, neratinib, AZD8931, dacomitinib, osimertinib, erlotinib, XL.647, gefitinib, afatinib, canertinib, poziotinib",Inf,1.5003129173816,TRUE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.37517,-0.915,0.568,1227,0.85,"metatinib, bosutinib, ZM.306416",0.245651664288981,0.0705810742857073,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.52402,1.42,0.135,407,0.303,"tremorine, nefiracetam, oxiracetam, nicotine, pilocarpine",0.869666231504994,0.518557371497695,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",0.46524,1.29,0.161,19,0.395,"iododexetimide",0.79317412396815,0.40340290437354,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",-0.54128,-1.33,0.147,1443,0.455,"CGS.15943",0.832682665251824,0.341988603342888,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",0.37474,1.03,0.411,386,0.558,"ritodrine, isoxsuprine, isoetharine, oxymetazoline, norepinephrine, epinephrine, xylazine",0.386158178123931,0.253365801062421,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",-0.22971,-0.571,0.932,1081,1,"dihydroergocristine, vincamine, carvedilol, RS.17053, imiloxan",0.0305840876460186,0,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.60551,-1.45,0.0902,1305,0.361,"CCT128930, GDC.0068, triciribine, uprosertib",1.04479346245806,0.442492798094342,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.73298,-1.78,0.0147,1246,0.134,"SB.505124, CEP.37440, alectinib, NVP.TAE684, AZD3463, brigatinib",1.83268266525182,0.872895201635192,TRUE
+"HCC95","Pearson.est","androgen receptor antagonist",0.63795,1.67,0.0458,222,0.201,"bicalutamide, enzalutamide",1.33913452199613,0.696803942579511,TRUE
+"HCC95","Pearson.est","antioxidant",0.74347,2.06,0,200,0.0553,"benfotiamine, chlorogenic.acid, trolox, mesna",Inf,1.2572748686953,TRUE
+"HCC95","Pearson.est","AP inhibitor",0.41269,1.15,0.277,22,0.442,"idronoxil",0.557520230935551,0.354577730650908,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",-0.5272,-1.27,0.186,1057,0.497,"digitoxigenin, omeprazole, evodiamine, digoxin, oligomycin.a, NMS.873, k.strophanthidin, rabeprazole",0.730487055782084,0.303643611266668,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",-0.65344,-1.59,0.0318,1085,0.271,"barasertib, GSK1070916, CCT137690, PF.03814735, MK.5108, alisertib, aurora.a.inhibitor.i, ENMD.2076, CCT129202, hesperadin, MLN.8054, MK.8745, CYC116, ZM.447439, TAK.901, danusertib, barasertib.HQPA, PHA.680632",1.49757288001557,0.567030709125594,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45658,-1.12,0.318,1024,0.646,"tedizolid, valnemulin, azithromycin, radezolid",0.497572880015567,0.189767482004916,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.56518,1.58,0.0733,116,0.225,"nadifloxacin, novobiocin, sparfloxacin",1.13489602535887,0.647817481888638,FALSE
+"HCC95","Pearson.est","BCL inhibitor",0.53749,1.47,0.107,400,0.279,"oridonin, venetoclax, ABT.737, navitoclax, gossypol",0.97061622231479,0.554395796726402,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.24612,-0.59,0.909,1227,1,"metatinib, bosutinib",0.0414361167780325,0,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.20328,-0.498,0.981,1064,1,"ZK.93423, ivermectin, bentazepam",0.0083309926200515,0,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",-0.5225,-1.3,0.193,1029,0.463,"JQ1...., I.BET151, OTX015, I.BET.762",0.714442690992226,0.334419008982047,FALSE
+"HCC95","Pearson.est","calcium channel blocker",-0.42758,-1.06,0.373,873,0.691,"tetrandrine, fendiline, carboxyamidotriazole, efonidipine.monoethanolate, penfluridol",0.428291168191312,0.160521952625802,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.25951,-0.63,0.906,1044,1,"MK.0812, SB.225002, ZK811752",0.0428718023231869,0,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.60637,-1.47,0.0849,1012,0.386,"CR8..R., ribociclib, palbociclib, PHA.848125, dinaciclib, alvocidib, TG.02, aminopurvalanol.a, R547, arcyriaflavin.a, JNJ.7706621, indisulam, BMS.265246, PHA.793887, BMS.387032, AT.7519",1.07109230975605,0.413412695328245,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.39923,-0.975,0.489,765,0.784,"AZD7762, PF.477736, CHIR.124, LY2603618, SB.218078",0.31069114087638,0.105683937315562,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.1866,-0.455,0.991,787,1,"indoprofen, sulfasalazine, curcumin, piroxicam, aspirin, phenazone, FR.122047, ramifenazone, FK.3311, tryptanthrin, amfenac",0.00392634551472468,0,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.62507,1.79,0.0261,181,0.167,"metyrapone, morin, clotrimazole",1.58335949266172,0.777283528852417,TRUE
+"HCC95","Pearson.est","DNA alkylating agent",-0.28241,-0.687,0.819,1096,1,"cyclophosphamide, mitomycin.c, estramustine, dacarbazine",0.0867160982395816,0,FALSE
+"HCC95","Pearson.est","DNA inhibitor",0.37521,1.02,0.411,248,0.524,"nimorazole, metronidazole, carboplatin, bendamustine, pibenzimol, nithiamide, carmustine",0.386158178123931,0.280668713016273,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.66148,-1.59,0.042,1146,0.271,"fdcyd, SGI.1027, azacitidine, decitabine",1.3767507096021,0.567030709125594,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",-0.2787,-0.678,0.859,1380,1,"cephalomannine",0.0660068361687577,0,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.41843,-1.03,0.427,1211,0.727,"mitomycin.c, anisomycin, cyclocytidine, enocitabine",0.369572124974976,0.138465589140962,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",0.22873,0.63,0.87,144,1,"amisulpride, clebopride, ziprasidone",0.0604807473813815,0,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.3061,-0.738,0.765,1362,1,"levonorgestrel",0.116338564846382,0,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",0.42984,1.18,0.257,92,0.428,"danazol, toremifene",0.590066876668705,0.368556230986828,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",0.21958,0.616,0.898,202,0.977,"erdafitinib, orantinib",0.0467236633326956,0.0101054362812269,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",0.20475,0.556,0.962,397,0.987,"GTP.14564, ponatinib, gilteritinib, midostaurin, KW.2449, dovitinib, tyrphostin.AG.1296, tandutinib",0.0168249279621871,0.00568284733036327,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.40631,-0.988,0.459,1001,0.784,"betamethasone, methylprednisolone, halcinonide, difluprednate, clobetasol.propionate, flumethasone.pivalate, deflazacort, beclomethasone.dipropionate, triamcinolone.acetonide, halobetasol.propionate, ciclesonide, flumethasone, fluorometholone",0.338187314462739,0.105683937315562,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",-0.17529,-0.424,0.997,1344,0.995,"LY456236",0.00130484168834428,0.00217691925427455,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.73408,2.03,0,130,0.0522,"CHIR.98014, CHIR.99021, GSK.3.inhibitor.IX, tideglusib, LY2090314",Inf,1.28232949699774,TRUE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.55436,-1.33,0.161,935,0.455,"lestaurtinib, PHA.848125, GSK1838705A, danusertib, AZD3463",0.79317412396815,0.341988603342888,FALSE
+"HCC95","Pearson.est","HCV inhibitor",0.24965,0.668,0.869,1088,0.993,"Ro.9187, embelin, mericitabine, daclatasvir, PSI.7976, narlaprevir",0.0609802235513335,0.00305075150461883,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.38257,-0.928,0.537,847,0.851,"resminostat, R306465, RGFP966, chidamide, AR.42, belinostat, ACY.1215, M.344, trichostatin.a, NSC.3852, scriptaid, vorinostat, PCI.24781, JNJ.26481585, givinostat, dacinostat, SB.939",0.270025714300444,0.0700704399154121,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",0.12867,0.35,1,1264,1,"epinastine, lafutidine, chloropyramine, nizatidine, famotidine, ICI.162846, cimetidine, pheniramine, tecastemizole, astemizole, ranitidine, tiotidine, cyproheptadine, zolantidine, BF2.649, terfenadine, levocetirizine, ebastine",0,0,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.9154,2.5,0,128,0,"lovastatin, pitavastatin, fluvastatin, mevastatin, atorvastatin, simvastatin",Inf,Inf,TRUE
+"HCC95","Pearson.est","HSP inhibitor",-0.58608,-1.4,0.116,931,0.375,"ganetespib, XL888, VER.49009, alvespimycin, NVP.AUY922, BIIB021, KW.2478, tanespimycin, PU.H71",0.935542010773082,0.425968732272281,FALSE
+"HCC95","Pearson.est","JAK inhibitor",-0.53095,-1.31,0.193,1008,0.468,"baricitinib, AT.9283, LY2784544, WHI.P154, TG.02, AZD1480, ruxolitinib, AZ960, pacritinib, filgotinib, PRT062070",0.714442690992226,0.329754146925876,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.19135,-0.465,0.993,1033,1,"lenvatinib, vatalanib, cediranib, OSI.930",0.00305075150461883,0,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.85188,2.36,0,71,0.00404,"AMG.232, idasanutlin, CGM097, nutlin.3",Inf,2.3936186348894,TRUE
+"HCC95","Pearson.est","MEK inhibitor",0.43088,1.18,0.267,392,0.428,"refametinib, BIX.02188, cobimetinib, U.0126, TAK.733, MEK1.2.inhibitor, PD.184352, MEK162",0.573488738635425,0.368556230986828,FALSE
+"HCC95","Pearson.est","MET inhibitor",0.60658,1.68,0.0458,213,0.226,"PHA.665752, NVP.BVU972, AMG458",1.33913452199613,0.645891560852599,TRUE
+"HCC95","Pearson.est","microtubule inhibitor",-0.59596,-1.46,0.0804,1139,0.373,"podophyllotoxin, colchicine, vinflunine, cabazitaxel, D.64131",1.09474395125155,0.428291168191312,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.45945,-1.12,0.329,1056,0.646,"PP242, torin.1, MLN0128, WYE.125132, torin.2, deforolimus, AZD8055, PI.103, GDC.0980, WYE.354, GSK2126458, PF.05212384",0.482804102050026,0.189767482004916,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",-0.20611,-0.5,0.983,832,1,"curcumin, parthenolide...., IKK.2.inhibitor.V, parthenolide, Ro.106.9920, EVP4593",0.00744648216786438,0,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",0.49728,1.33,0.166,103,0.373,"BW.180C, ADL5859",0.779891911959945,0.428291168191312,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",-0.58875,-1.41,0.103,1240,0.381,"CMPD.1, SB.239063, talmapimod",0.987162775294828,0.419075024324381,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.36089,-0.872,0.62,907,0.908,"AZD2461, olaparib, PJ.34, niraparib, talazoparib",0.207608310501746,0.0419141514789149,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.2569,0.705,0.784,464,0.976,"KI.8751, orantinib, ponatinib, linifanib, dovitinib, CP.673451, telatinib, tandutinib, pazopanib, sunitinib, regorafenib, trapidil",0.105683937315562,0.0105501823333082,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.45718,1.25,0.212,232,0.418,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, menadione, CID.5458317",0.673664139071249,0.378823718224965,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.37454,1.02,0.41,121,0.524,"anagrelide, GSK256066, enoximone",0.387216143280265,0.280668713016273,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.49432,-1.19,0.253,1196,0.604,"TG.100713, PI.103, GDC.0980, PIK.75, GSK2126458, CH5132799, PF.05212384, alpelisib, taselisib",0.596879478824182,0.218963061378868,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.814,-1.97,0,1348,0.0307,"GW.843682X, HMN.214, BI.2536, volasertib, NMS.1286937",Inf,1.51286162452281,TRUE
+"HCC95","Pearson.est","potassium channel blocker",0.3966,1.13,0.308,212,0.444,"meglitinide, ML133",0.511449283499556,0.35261702988538,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.57999,1.62,0.0655,132,0.219,"fenofibrate, S26948, clofibrate",1.18375870000822,0.659555885159882,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",0.54867,1.48,0.1,198,0.297,"norethindrone, nomegestrol.acetate, danazol, norethindrone.acetate, norgestrel",1,0.527243550682788,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",-0.44815,-1.07,0.368,1178,0.696,"carfilzomib",0.434152181326482,0.157390760389438,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",-0.51442,-1.22,0.22,1181,0.57,"thiostrepton, cycloheximide, harringtonine, anguidine, puromycin, homoharringtonine, tedizolid.phosphate, bruceantin",0.657577319177794,0.244125144327509,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.74314,-1.78,0.00855,1372,0.134,"BMS.599626, NVP.TAE226, CP.724714, AV.412",2.06803388527183,0.872895201635192,TRUE
+"HCC95","Pearson.est","RAF inhibitor",0.44794,1.24,0.235,35,0.403,"dabrafenib, vemurafenib",0.628932137728264,0.39469495385889,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.32328,-0.791,0.708,1037,1,"cabozantinib, vandetanib",0.149966742310231,0,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.35302,-0.86,0.627,971,0.905,"adarotene, bexarotene, adapalene, CD.437",0.202732459169284,0.0433514207947967,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.30177,0.832,0.625,241,0.794,"pentostatin, hydroxyurea, fludarabine",0.204119982655925,0.100179497572904,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.65005,-1.57,0.0427,1238,0.27,"zolmitriptan, pardoprunox, aripiprazole",1.36957212497498,0.568636235841013,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",-0.31608,-0.766,0.763,1436,1,"aripiprazole",0.11747546204512,0,FALSE
+"HCC95","Pearson.est","sodium channel blocker",-0.24539,-0.589,0.927,960,1,"benzethonium, triamterene, lappaconite, A.803467, brivaracetam",0.0329202658555029,0,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.71705,-1.73,0.0171,1369,0.157,"bosutinib, saracatinib, ZM.306416",1.76700388960785,0.804100347590766,TRUE
+"HCC95","Pearson.est","sterol demethylase inhibitor",-0.23717,-0.582,0.918,342,1,"posaconazole, terconazole, ketoconazole, chlormidazole, sulconazole, lanoconazole",0.0371573187987575,0,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.60175,-1.47,0.0727,1083,0.386,"adaprev, SB.525334, D.4476, repsox",1.13846558914096,0.413412695328245,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.24124,-0.593,0.905,1268,1,"carmofur",0.0433514207947967,0,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",-0.43995,-1.07,0.395,798,0.696,"licochalcone.a, epirubicin, voreloxin, valrubicin, teniposide, idarubicin, daunorubicin, beta.lapachone, etoposide, amsacrine, TAS.103, irinotecan, mitoxantrone, genz.644282, amonafide, camptothecin, SN.38, exatecan.mesylate, dexrazoxane",0.40340290437354,0.157390760389438,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.6977,-1.68,0.0192,1139,0.198,"podophyllotoxin, combretastatin.A.4, flubendazole, indibulin, CYT.997, plinabulin, albendazole, fenbendazole, vincristine, mebendazole, dolastatin.10, fosbretabulin, taltobulin, nocodazole, ABT.751, vinorelbine, epothilone.b, parbendazole, docetaxel, paclitaxel",1.71669877129645,0.703334809738469,TRUE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.46455,-1.12,0.336,1372,0.646,"BMS.599626, NVP.TAE226, CP.724714, AV.412, tivantinib",0.473660722610156,0.189767482004916,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.47148,-1.15,0.289,933,0.662,"SAR131675, RAF265, TG.100572, golvatinib, foretinib, semaxanib, lenvatinib, cabozantinib, SU014813, vatalanib, cediranib, ENMD.2076, PD.173074, lucitanib, vandetanib, OSI.930, ZM.306416, AEE788, BMS.690514, XL.647",0.539102157243452,0.1791420105603,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",-0.58103,-1.44,0.102,846,0.353,"ercalcitriol, calcitriol, doxercalciferol, paricalcitol, tacalcitol, maxacalcitol",0.991399828238082,0.452225294612177,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.75378,1.74,0.0062,170,0.215,"gefitinib, poziotinib, AZD8931, afatinib, AST.1306, neratinib, dacomitinib, erlotinib, pelitinib, XL.647, BIBU.1361, CUDC.101, lapatinib, osimertinib, BMS.690514, canertinib, ARRY.334543, vandetanib, WZ.4002, tucatinib, CNX.2006, PD.153035, BIBX.1382, AEE788, BMS.599626, icotinib",2.20760831050175,0.667561540084395,TRUE
+"H1975","Pearson.est","Abl kinase inhibitor",0.44677,1.06,0.405,666,0.769,"ZM.306416, dasatinib, bosutinib, bafetinib, nilotinib, GZD824, imatinib, tozasertib",0.392544976785331,0.114073660198569,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",0.31852,0.738,0.792,634,0.941,"pilocarpine, tremorine, xanomeline, oxiracetam",0.101274818410506,0.0264103765727431,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",-0.3726,-1.03,0.407,1262,0.869,"iododexetimide, methscopolamine",0.39040559077478,0.0609802235513335,FALSE
+"H1975","Pearson.est","adenosine receptor antagonist",0.53704,1.27,0.188,399,0.549,"CGS.15943, PSB.1115, istradefylline, MRS.1220, SCH.58261, sulmazole",0.72584215073632,0.260427655549908,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",-0.42733,-1.23,0.165,1186,0.749,"clenbuterol, midodrine, epinephrine, A61603, norepinephrine, lidamidine, xylazine",0.782516055786094,0.125518182300534,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.2973,0.689,0.845,567,0.94,"atenolol......, dihydroergocristine, dronedarone, oxprenolol, imiloxan, idazoxan, practolol, naftidrofuryl, prazosin",0.0731432910503077,0.0268721464003014,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.42379,0.995,0.475,438,0.76,"uprosertib, triciribine, palomid.529, GDC.0068, GSK2110183",0.323306390375133,0.119186407719209,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41655,0.969,0.521,727,0.749,"AZD3463, alectinib, CEP.37440, SB.505124, NVP.TAE684, brigatinib, crizotinib, DMH1, lorlatinib",0.283162276700476,0.125518182300534,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",-0.32119,-0.878,0.551,1255,0.943,"enzalutamide, flutamide",0.258848401148215,0.0254883072626717,FALSE
+"H1975","Pearson.est","antioxidant",-0.35198,-1.01,0.369,1332,0.853,"taurine, rutin",0.43297363384094,0.069050968832477,FALSE
+"H1975","Pearson.est","AP inhibitor",-0.71291,-2.1,0,1426,0.081,"birinapant, LCL.161, GDC.0152",Inf,1.09151498112135,TRUE
+"H1975","Pearson.est","ATPase inhibitor",-0.39797,-1.14,0.263,1224,0.724,"oligomycin.a, blebbistatin...., ouabain, digitoxigenin, digitoxin, omeprazole",0.580044251510242,0.140261433802853,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",0.42594,1,0.448,690,0.795,"ENMD.2076, PHA.680632, danusertib, CCT137690, hesperadin, barasertib.HQPA, CCT129202, GSK1070916, alisertib, AT.9283, CYC116, SNS.314, barasertib, tozasertib, MK.8745, PF.03814735",0.348721986001856,0.0996328713435297,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.42094,0.966,0.521,600,0.716,"azithromycin, azalomycin.b, tilmicosin, tedizolid, valnemulin, radezolid",0.283162276700476,0.145086977692144,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.30415,-0.851,0.632,1428,0.864,"sparfloxacin",0.199282921717615,0.0634862575211067,FALSE
+"H1975","Pearson.est","BCL inhibitor",0.63111,1.45,0.0754,166,0.557,"obatoclax, gossypol, TW.37",1.12262865413023,0.254144804826271,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",0.43761,1.03,0.423,666,0.783,"dasatinib, bosutinib, bafetinib, nilotinib, GZD824, imatinib, tozasertib",0.373659632624958,0.106238237942057,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.27345,0.626,0.912,377,0.944,"eprinomectin, zaleplon, ZK.93423, piperazine",0.0400051616715838,0.025028005701931,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",0.71298,1.67,0.0114,303,0.265,"JQ1...., I.BET151, bromosporine, OTX015, I.BET.762",1.94309514866353,0.576754126063192,FALSE
+"H1975","Pearson.est","calcium channel blocker",0.47116,1.09,0.353,256,0.783,"tetrandrine, cinnarazine, mibefradil",0.452225294612177,0.106238237942057,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",0.46866,1.09,0.358,648,0.783,"ZK811752, SB.225002, PF.04136309, navarixin",0.446116973356126,0.106238237942057,FALSE
+"H1975","Pearson.est","CDK inhibitor",0.56804,1.3,0.155,556,0.509,"TG.02, P276.00, R547, JNJ.7706621, indisulam, ribociclib, aminopurvalanol.a, PHA.848125, AZD5438, palbociclib, alvocidib, indirubin, BMS.387032, arcyriaflavin.a, AT.7519, NU6027, dinaciclib, abemaciclib",0.809668301829709,0.293282217663241,FALSE
+"H1975","Pearson.est","CHK inhibitor",0.30654,0.707,0.846,781,0.939,"AZD7762, SB.218078, LY2603618, CHIR.124, PF.477736",0.0726296369609765,0.0273344077338891,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.20462,-0.592,0.908,1236,1,"amfenac, acetylsalicylsalicylic.acid, naproxen, AM.404, suxibuzone, metoxibutropate",0.0419141514789149,0,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.28623,-0.809,0.674,1244,0.903,"eplerenone, clotrimazole",0.17134010346468,0.0443122496864942,FALSE
+"H1975","Pearson.est","DNA alkylating agent",-0.19577,-0.535,0.979,1259,1,"carboplatin, dianhydrogalactitol, cisplatin",0.00921730819686218,0,FALSE
+"H1975","Pearson.est","DNA inhibitor",0.37094,0.865,0.642,684,0.815,"mechlorethamine, oxaliplatin, bendamustine, carmustine, nimorazole, sangivamycin, valrubicin, melphalan, nithiamide, busulfan",0.192464971931147,0.0888423912600234,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.59498,1.38,0.0907,213,0.531,"fdcyd, azacitidine, disulfiram",1.0423927129399,0.274905478918531,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",0.44102,1.04,0.426,333,0.786,"idoxuridine, adefovir.dipivoxil, trifluridine, cidofovir",0.370590400897281,0.104577453960592,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",0.32948,0.764,0.781,366,0.949,"anisomycin, enocitabine, cyclocytidine, floxuridine, CB.10.277",0.1073489661227,0.0227337875727074,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",0.42308,0.997,0.468,125,0.778,"mesoridazine, sertindole, domperidone",0.329754146925876,0.109020403010311,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.31695,-0.896,0.538,1386,0.953,"estradiol, estradiol.cypionate",0.269217724333611,0.0209070993616736,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",0.45424,1.07,0.385,289,0.774,"clomifene, raloxifene",0.414539270491499,0.111259039317107,FALSE
+"H1975","Pearson.est","FGFR inhibitor",0.32505,0.755,0.801,335,0.939,"regorafenib, PD.173074, dovitinib",0.0963674839157623,0.0273344077338891,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",0.4293,0.993,0.483,666,0.742,"pacritinib, TG.02, ENMD.2076, dovitinib, TG.101348, gilteritinib, sorafenib, GTP.14564, quizartinib, lestaurtinib, sunitinib, tozasertib",0.316052869248488,0.129596094720973,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",0.70775,1.63,0.0201,234,0.279,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate, desonide, halobetasol.propionate, rimexolone, methylprednisolone, halcinonide, fluocinolone.acetonide, flumethasone.pivalate, prednisolone, clobetasol.propionate, deflazacort, prednisolone.acetate, fludroxycortide, triamcinolone",1.69680394257951,0.554395796726402,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",0.25863,0.598,0.9,176,0.929,"CPP, CGP.37849",0.0457574905606751,0.0319842860063582,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.30987,-0.867,0.575,1192,0.873,"tideglusib, CHIR.99021, CHIR.98014",0.24033215531037,0.0589857562944303,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",0.58508,1.36,0.127,577,0.494,"danusertib, AZD3463, GSK1838705A, PHA.848125, GSK1904529A, lestaurtinib",0.896196279044043,0.306273051076353,FALSE
+"H1975","Pearson.est","HCV inhibitor",0.3914,0.92,0.575,231,0.743,"embelin",0.24033215531037,0.129011186239425,FALSE
+"H1975","Pearson.est","HDAC inhibitor",0.41467,0.967,0.508,456,0.732,"PCI.24781, givinostat, AR.42, trichostatin.a, M.344, RGFP966, R306465, dacinostat, belinostat, scriptaid, NSC.3852, vorinostat, SB.939",0.294136287716081,0.135488918941608,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",-0.20597,-0.569,0.939,1228,1,"zolantidine, tiotidine, cimetidine, lafutidine, chloropyramine",0.0273344077338891,0,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.8444,-2.41,0,1281,0.0088,"atorvastatin, fluvastatin, pitavastatin, mevastatin",Inf,2.05551732784983,TRUE
+"H1975","Pearson.est","HSP inhibitor",-0.52195,-1.49,0.0739,1091,0.501,"BIIB021, PU.H71, NMS.E973, ganetespib, NVP.AUY922, guanidine, KW.2478, alvespimycin",1.13135556160517,0.300162274132754,FALSE
+"H1975","Pearson.est","JAK inhibitor",0.4837,1.12,0.329,360,0.807,"pacritinib, atiprimod, TG.02, AZ960, TG.101209, AZD1480, LY2784544, TG.101348",0.482804102050026,0.0931264652779296,FALSE
+"H1975","Pearson.est","KIT inhibitor",0.26704,0.621,0.921,653,0.93,"OSI.930, regorafenib, dasatinib, sorafenib, masitinib, imatinib, sunitinib",0.0357403698031511,0.0315170514460649,FALSE
+"H1975","Pearson.est","MDM inhibitor",0.75333,1.75,0.00493,222,0.393,"nutlin.3, idasanutlin, RITA, CGM097, serdemetan",2.30715308072277,0.405607449624573,FALSE
+"H1975","Pearson.est","MEK inhibitor",0.66147,1.56,0.0418,107,0.38,"cobimetinib, AS.703026, trametinib, PD.0325901, AZD8330, selumetinib, TAK.733, Ro.4987655, MEK162",1.37882371822496,0.42021640338319,FALSE
+"H1975","Pearson.est","MET inhibitor",-0.62097,-1.72,0.0591,1261,0.27,"PF.04217903, LY2801653",1.22841251911874,0.568636235841013,FALSE
+"H1975","Pearson.est","microtubule inhibitor",-0.38804,-1.08,0.335,558,0.808,"podophyllotoxin, D.64131, secnidazole, triclabendazole, vinflunine, colchicine, cabazitaxel, estramustine.phosphate, vinblastine, cytochalasin.b",0.474955192963155,0.0925886392254138,FALSE
+"H1975","Pearson.est","mTOR inhibitor",0.60923,1.42,0.1,364,0.519,"GSK2126458, WAY.600, WYE.354, AZD8055, XL388, WYE.125132, PP242, OSI.027, voxtalisib, LY303511, AZD2014, torin.2, PF.04691502, torin.1, GDC.0980, palomid.529",1,0.284832642151542,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",0.27781,0.648,0.912,363,0.942,"EVP4593, curcumin, betulinic.acid",0.0400051616715838,0.0259490972071227,FALSE
+"H1975","Pearson.est","opioid receptor agonist",-0.40275,-1.14,0.28,1312,0.724,"ADL5859, BW.180C, spiradoline",0.552841968657781,0.140261433802853,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",0.58902,1.38,0.1,565,0.531,"SB.242235, CMPD.1, skepinone.l, talmapimod, SB.239063, VX.702",1,0.274905478918531,FALSE
+"H1975","Pearson.est","PARP inhibitor",-0.32294,-0.908,0.522,1372,0.982,"olaparib, E7449",0.282329496997738,0.00788851221305034,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.27858,-0.792,0.762,1257,0.897,"motesanib, trapidil, nintedanib, SU014813, CP.673451, linifanib",0.1180450286604,0.0472075569559079,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",0.28426,0.654,0.866,637,0.956,"alexidine, mycophenolic.acid, mycophenolate.mofetil, sodium.stibogluconate, CID.5458317, GSK2830371",0.0624821079826534,0.0195421077238999,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",-0.32359,-0.953,0.469,1177,0.932,"zardaverine, anagrelide, YM.976, GSK256066, enoximone",0.328827157284917,0.0305840876460186,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.56867,1.34,0.132,526,0.508,"GSK2126458, taselisib, YM.201636, GDC.0941, alpelisib, buparlisib, voxtalisib, PI3K.IN.2, LY303511, CH5132799, PIK.75, PF.04691502, GDC.0980, CUDC.907, PI.828, AZD6482, TG.100713, BGT226, pilaralisib, PI.103, PKI.179",0.87942606879415,0.294136287716081,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.48608,1.15,0.293,189,0.796,"NMS.1286937",0.533132379645891,0.0990869322623309,FALSE
+"H1975","Pearson.est","potassium channel blocker",-0.32401,-0.871,0.58,1375,0.911,"dofetilide",0.236572006437063,0.0404816230270017,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",-0.4364,-1.25,0.183,1220,0.808,"fenofibrate, S26948, clofibrate",0.737548910269571,0.0925886392254138,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.43153,-1.22,0.19,1358,0.689,"norethindrone, dienogest, norgestrel",0.721246399047171,0.161780778092374,FALSE
+"H1975","Pearson.est","proteasome inhibitor",-0.50534,-1.46,0.0545,1389,0.462,"ONX.0914, delanzomib",1.26360349772336,0.335358024443874,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.41908,0.987,0.482,515,0.734,"brefeldin.a, cycloheximide, azomycin..2.nitroimidazole., homoharringtonine, clindamycin.phosphate, anguidine, bruceantin, emetine, thiostrepton",0.31695296176115,0.134303940083929,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.6247,1.49,0.0605,243,0.507,"NVP.TAE226, AV.412, BMS.599626, tyrphostin.A9, CP.724714",1.21824462534753,0.294992040666664,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.56058,1.32,0.148,223,0.523,"AZ.628, SB.590885, CEP.32496, regorafenib, LGX818",0.829738284605043,0.281498311132726,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.5478,1.3,0.159,653,0.509,"vandetanib, regorafenib, sorafenib, apatinib, sunitinib",0.798602875679548,0.293282217663241,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.45567,1.08,0.351,313,0.779,"CD.437, tamibarotene, adarotene",0.454692883534176,0.108462542327436,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.30906,0.716,0.829,660,0.948,"cytarabine, fludarabine.phosphate, LY2334737, triapine, clofarabine",0.0814454694497265,0.0231916626619338,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.67324,-2.01,0.0193,1288,0.0998,"SR.57227A, pardoprunox, aripiprazole",1.71444269099223,1.00086945871263,TRUE
+"H1975","Pearson.est","serotonin receptor antagonist",0.39151,0.928,0.57,267,0.747,"SB.228357, SB.200646, sertindole, SB.216641, pirenperone",0.244125144327509,0.126679398184601,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.22201,-0.619,0.917,1248,1,"lappaconite, oxcarbazepine, brivaracetam, cibenzoline",0.0376306643299789,0,FALSE
+"H1975","Pearson.est","src inhibitor",0.47974,1.14,0.313,356,0.787,"ZM.306416, saracatinib, dasatinib, bosutinib",0.504455662453552,0.104025267640935,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",0.43812,1.02,0.438,445,0.778,"lanoconazole, posaconazole, sulconazole",0.3585258894959,0.109020403010311,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.49183,1.15,0.316,461,0.796,"D.4476, SB.525334, SB.431542, repsox",0.500312917381596,0.0990869322623309,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.595,1.36,0.121,326,0.494,"carmofur, raltitrexed, trifluridine",0.91721462968355,0.306273051076353,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",-0.17217,-0.481,0.985,245,0.989,"amsacrine, idarubicin, SN.38, exatecan.mesylate, voreloxin, valrubicin, licochalcone.a, TAS.103, camptothecin, dexrazoxane, teniposide, doxorubicin, nemorubicin, beta.lapachone, topotecan, fleroxacin, mitoxantrone, genz.644282, rubitecan, daunorubicin, amonafide, irinotecan, etoposide, epirubicin, etoposide.phosphate",0.00656376950238827,0.0048037084028206,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",-0.20114,-0.559,0.958,1327,1,"docetaxel, vinblastine, paclitaxel, epothilone.d, BNC105",0.0186344909214556,0,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",0.47713,1.1,0.342,441,0.824,"NVP.TAE226, vandetanib, AV.412, hypericin, BMS.599626, tyrphostin.A9, regorafenib, CP.724714, dasatinib, aminopurvalanol.a, tivantinib, sorafenib, bafetinib",0.465973893943865,0.0840727883028842,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",0.40466,0.957,0.541,335,0.714,"XL.647, BMS.690514, ZM.306416, OSI.930, vandetanib, ENMD.2076, AEE788, regorafenib, golvatinib, PD.173074, dovitinib",0.266802734893431,0.146301788223826,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.6109,1.43,0.084,459,0.549,"tacalcitol, alfacalcidol, ercalcitriol, calcitriol, maxacalcitol",1.07572071393812,0.260427655549908,FALSE
+"H1648","Pearson.est","EGFR inhibitor",-0.8675,-2.36,0.00325,1404,0.00209,"icotinib, BIBU.1361, PD.153035, AST.1306, TAK.285, AEE788, rociletinib, vandetanib, WZ8040, CP.724714, BMS.599626, BIBX.1382, pelitinib, GW.583340, ARRY.334543, PD.168393, erlotinib, gefitinib, osimertinib, afatinib, BMS.690514, lapatinib, dacomitinib, XL.647, canertinib, tucatinib, neratinib, poziotinib, AZD8931",2.48811663902113,2.67985371388895,TRUE
+"H1648","Pearson.est","Abl kinase inhibitor",0.46859,1.11,0.335,264,0.59,"GZD824, tozasertib, ponatinib, nilotinib, bafetinib, KW.2449, flumatinib",0.474955192963155,0.229147988357856,FALSE
+"H1648","Pearson.est","acetylcholine receptor agonist",0.52918,1.26,0.182,36,0.488,"oxiracetam",0.739928612014925,0.311580177997289,FALSE
+"H1648","Pearson.est","acetylcholine receptor antagonist",0.50363,1.2,0.267,520,0.528,"iododexetimide, diphemanil, darifenacin",0.573488738635425,0.277366077466188,FALSE
+"H1648","Pearson.est","adenosine receptor antagonist",-0.48527,-1.27,0.196,1291,0.559,"theophylline, MRS.1220, CGS.15943",0.707743928643524,0.252588192113577,FALSE
+"H1648","Pearson.est","adrenergic receptor agonist",0.26433,0.634,0.903,794,0.985,"buphenine, isoetharine, oxymetazoline, norepinephrine, metaraminol, ritodrine, clenbuterol, lidamidine, isoxsuprine, midodrine",0.0443122496864942,0.00656376950238827,FALSE
+"H1648","Pearson.est","adrenergic receptor antagonist",0.37103,0.879,0.615,452,0.785,"oxprenolol, metoprolol, carvedilol, naftidrofuryl, levobunolol, atipamezole, idazoxan",0.211124884224583,0.105130343254747,FALSE
+"H1648","Pearson.est","AKT inhibitor",-0.62829,-1.65,0.0645,1247,0.323,"A.674563, GSK2110183, CCT128930, triciribine, uprosertib, GDC.0068",1.19044028536473,0.490797477668897,FALSE
+"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27322,-0.707,0.798,1360,0.955,"GW.788388, brigatinib",0.0979971086492706,0.0199966284162537,FALSE
+"H1648","Pearson.est","androgen receptor antagonist",0.51595,1.23,0.217,268,0.488,"nilutamide, bicalutamide",0.66354026615147,0.311580177997289,FALSE
+"H1648","Pearson.est","antioxidant",0.63141,1.51,0.0641,258,0.451,"trolox, benfotiamine, chlorogenic.acid",1.19314197048118,0.345823458122039,FALSE
+"H1648","Pearson.est","AP inhibitor",0.45152,1.07,0.374,239,0.593,"idronoxil, embelin",0.42712839779952,0.226945306635737,FALSE
+"H1648","Pearson.est","ATPase inhibitor",0.30413,0.731,0.807,615,0.933,"digoxin, blebbistatin...., digitoxin, ouabain, thonzonium, evodiamine, digitoxigenin",0.0931264652779296,0.0301183562535,FALSE
+"H1648","Pearson.est","Aurora kinase inhibitor",0.42414,1.02,0.446,412,0.629,"barasertib, tozasertib, AT.9283, AMG900, SNS.314, KW.2449, PF.03814735, hesperadin, barasertib.HQPA, ENMD.2076, alisertib",0.350665141287858,0.201349354554731,FALSE
+"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36159,-0.954,0.46,1248,0.974,"josamycin, tedizolid, azithromycin",0.337242168318426,0.0114410431213845,FALSE
+"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.21439,0.521,0.98,633,0.987,"novobiocin, sparfloxacin, norfloxacin, sarafloxacin",0.00877392430750515,0.00568284733036327,FALSE
+"H1648","Pearson.est","BCL inhibitor",0.48386,1.17,0.263,553,0.513,"venetoclax, TW.37, oridonin, gossypol, ABT.737",0.580044251510242,0.289882634888184,FALSE
+"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.55817,1.34,0.137,264,0.608,"GZD824, tozasertib, ponatinib, nilotinib, bafetinib, flumatinib",0.863279432843593,0.216096420727265,FALSE
+"H1648","Pearson.est","benzodiazepine receptor agonist",0.31877,0.765,0.761,656,0.926,"temazepam, indiplon, ZK.93423, eprinomectin, zaleplon, piperazine, gamma.aminobutyric.acid",0.118615343229427,0.0333890133180656,FALSE
+"H1648","Pearson.est","bromodomain inhibitor",-0.27947,-0.74,0.757,403,0.948,"bromosporine, PFI.1, I.BET.762, I.BET151, JQ1...., OTX015",0.120904120499927,0.0231916626619338,FALSE
+"H1648","Pearson.est","calcium channel blocker",-0.28169,-0.762,0.782,1325,1,"fendiline, SKF.96365",0.106793246940152,0,FALSE
+"H1648","Pearson.est","CC chemokine receptor antagonist",0.68501,1.63,0.0204,357,0.485,"UNBS.5162, navarixin, PF.04136309, SB.225002, MK.0812",1.6903698325741,0.314258261397736,FALSE
+"H1648","Pearson.est","CDK inhibitor",-0.25131,-0.64,0.893,1371,1,"BMS.387032, indirubin, AT.7519",0.0491485411114536,0,FALSE
+"H1648","Pearson.est","CHK inhibitor",-0.47606,-1.27,0.197,686,0.559,"SB.218078, PF.477736, SCH.900776, AZD7762, LY2606368, CHIR.124, LY2603618",0.705533773838407,0.252588192113577,FALSE
+"H1648","Pearson.est","cyclooxygenase inhibitor",-0.20309,-0.541,0.961,1336,0.962,"tryptanthrin, ramifenazone, FK.3311, amfenac",0.0172766123314547,0.0168249279621871,FALSE
+"H1648","Pearson.est","cytochrome P450 inhibitor",0.60897,1.45,0.0874,370,0.495,"metyrapone, morin, cobicistat, itraconazole",1.0584885673656,0.305394801066431,FALSE
+"H1648","Pearson.est","DNA alkylating agent",0.37005,0.89,0.593,135,0.784,"melphalan, carboplatin, carmustine",0.226945306635737,0.105683937315562,FALSE
+"H1648","Pearson.est","DNA inhibitor",0.41542,0.991,0.478,417,0.663,"melphalan, carboplatin, chlorambucil, carmustine, pibenzimol, bendamustine, valrubicin, teroxirone",0.320572103387881,0.178486471595227,FALSE
+"H1648","Pearson.est","DNA methyltransferase inhibitor",-0.50353,-1.3,0.161,1380,0.655,"decitabine, azacitidine, SGI.1027",0.79317412396815,0.183758700008217,FALSE
+"H1648","Pearson.est","DNA polymerase inhibitor",0.26677,0.645,0.884,495,0.993,"foscarnet, idoxuridine, trifluridine",0.0535477349869269,0.00305075150461883,FALSE
+"H1648","Pearson.est","DNA synthesis inhibitor",0.49135,1.19,0.258,385,0.511,"nelarabine, azodicarbonamide, anisomycin, floxuridine, artesunate, artemisinin, CB.10.277",0.58838029403677,0.291579099865287,FALSE
+"H1648","Pearson.est","dopamine receptor antagonist",0.27846,0.661,0.852,193,0.997,"amisulpride, raclopride, paliperidone",0.0695604052332999,0.00130484168834428,FALSE
+"H1648","Pearson.est","estrogen receptor agonist",-0.27905,-0.746,0.786,1312,0.984,"erteberel, levonorgestrel",0.104577453960592,0.00700490156865849,FALSE
+"H1648","Pearson.est","estrogen receptor antagonist",0.45424,1.1,0.367,324,0.574,"fulvestrant, danazol, toremifene",0.435333935747911,0.241088107602027,FALSE
+"H1648","Pearson.est","FGFR inhibitor",0.64732,1.54,0.0435,236,0.441,"erdafitinib, dovitinib, regorafenib, nintedanib, MK.2461, orantinib",1.36151074304536,0.355561410532161,FALSE
+"H1648","Pearson.est","FLT3 inhibitor",0.62797,1.48,0.0585,294,0.47,"dovitinib, TG.101348, tozasertib, midostaurin, ponatinib, quizartinib, sunitinib, KW.2449, lestaurtinib, gilteritinib",1.23284413391782,0.327902142064283,FALSE
+"H1648","Pearson.est","glucocorticoid receptor agonist",-0.54631,-1.45,0.0886,1137,0.466,"difluprednate, dexamethasone.acetate, halobetasol.propionate, halcinonide, desonide, flumethasone.pivalate, methylprednisolone, beclomethasone.dipropionate, ciclesonide, fluorometholone, fludroxycortide, clobetasol.propionate, betamethasone, flumethasone, triamcinolone.acetonide",1.05256627811295,0.33161408331,FALSE
+"H1648","Pearson.est","glutamate receptor antagonist",0.15631,0.369,1,741,0.999,"MTPG, ACDPP, IEM1754, diazooxonorleucine, felbamate, CPP, SIB.1757",0,0.000434511774017692,FALSE
+"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.31993,0.767,0.744,459,0.943,"tideglusib, CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.128427064454121,0.0254883072626717,FALSE
+"H1648","Pearson.est","growth factor receptor inhibitor",0.37789,0.9,0.588,596,0.787,"lestaurtinib, danusertib, PHA.848125, GSK1838705A, AZD3463",0.230622673923862,0.104025267640935,FALSE
+"H1648","Pearson.est","HCV inhibitor",0.49252,1.18,0.272,384,0.513,"narlaprevir, embelin, mericitabine",0.565431095965801,0.289882634888184,FALSE
+"H1648","Pearson.est","HDAC inhibitor",0.30553,0.736,0.78,740,0.946,"entinostat, resminostat, dacinostat, trichostatin.a, RG2833, R306465, nexturastat.a, belinostat, M.344, vorinostat, ACY.1215, chidamide, scriptaid, NSC.3852, panobinostat",0.10790539730952,0.0241088635982073,FALSE
+"H1648","Pearson.est","histamine receptor antagonist",0.24554,0.588,0.939,491,0.985,"pheniramine, famotidine, cimetidine, tiotidine, lafutidine, ICI.162846, epinastine, nizatidine",0.0273344077338891,0.00656376950238827,FALSE
+"H1648","Pearson.est","HMGCR inhibitor",0.88532,2.13,0.00145,6,0.000981,"mevastatin, pitavastatin, fluvastatin, atorvastatin",2.83863199776503,3.00833099262005,TRUE
+"H1648","Pearson.est","HSP inhibitor",-0.32629,-0.849,0.641,1307,0.948,"VER.49009, tanespimycin, alvespimycin, KW.2478",0.193141970481183,0.0231916626619338,FALSE
+"H1648","Pearson.est","JAK inhibitor",0.45604,1.09,0.369,263,0.575,"TG.101348, tozasertib, AT.9283, TG.101209, AZ960, lestaurtinib",0.43297363384094,0.24033215531037,FALSE
+"H1648","Pearson.est","KIT inhibitor",0.50095,1.19,0.279,529,0.511,"KI.8751, midostaurin, pazopanib, regorafenib, sunitinib, masitinib, motesanib, telatinib, sorafenib, lenvatinib",0.554395796726402,0.291579099865287,FALSE
+"H1648","Pearson.est","MDM inhibitor",0.87828,2.14,0,80,0.00196,"idasanutlin, AMG.232, nutlin.3, CGM097, serdemetan",Inf,2.70774392864352,TRUE
+"H1648","Pearson.est","MEK inhibitor",-0.33511,-0.894,0.579,1141,0.912,"PD.198306, PD.318088, PD.0325901, PD.184352, AZD8330, Ro.4987655, selumetinib, AS.703026, trametinib",0.237321436272564,0.0400051616715838,FALSE
+"H1648","Pearson.est","MET inhibitor",-0.35399,-0.934,0.517,1422,0.947,"INC.280",0.286509456906058,0.0236500209967266,FALSE
+"H1648","Pearson.est","microtubule inhibitor",0.54939,1.3,0.158,133,0.498,"vinblastine, secnidazole, vinflunine",0.801342913045577,0.302770657240282,FALSE
+"H1648","Pearson.est","mTOR inhibitor",0.22145,0.537,0.964,669,0.998,"torin.1, ku.0063794, deforolimus, LY303511, WAY.600, SB.2343, LY3023414, sirolimus, NVP.BEZ235, PKI.179, XL388, temsirolimus, AZD8055, AZD2014",0.0159229660971692,0.000869458712628891,FALSE
+"H1648","Pearson.est","NFkB pathway inhibitor",-0.2305,-0.618,0.895,331,0.98,"BAY.11.7082, bortezomib, betulinic.acid, BAY.11.7085, curcumin, parthenolide...., parthenolide, bindarit, EVP4593, tyloxapol, Ro.106.9920, IKK.2.inhibitor.V",0.048176964684088,0.00877392430750515,FALSE
+"H1648","Pearson.est","opioid receptor agonist",0.59792,1.44,0.0795,518,0.473,"cebranopadol, trimebutine, BW.180C, spiradoline, salvinorin.a",1.09963287134353,0.325138859262188,FALSE
+"H1648","Pearson.est","p38 MAPK inhibitor",-0.42596,-1.09,0.361,1323,0.879,"SB.239063, talmapimod",0.442492798094342,0.0560111249262281,FALSE
+"H1648","Pearson.est","PARP inhibitor",0.55286,1.33,0.154,433,0.591,"talazoparib, AG.14361, niraparib, PJ.34",0.812479279163537,0.228412519118745,FALSE
+"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.54535,1.31,0.153,529,0.504,"KI.8751, dovitinib, axitinib, ponatinib, pazopanib, regorafenib, sunitinib, nintedanib, orantinib, masitinib, CP.673451, SU014813, crenolanib, trapidil, motesanib, telatinib, sorafenib, lenvatinib",0.815308569182401,0.297569463554475,FALSE
+"H1648","Pearson.est","phosphatase inhibitor",0.6766,1.6,0.0322,61,0.455,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, sodium.stibogluconate",1.49214412830417,0.341988603342888,FALSE
+"H1648","Pearson.est","phosphodiesterase inhibitor",0.53453,1.26,0.183,33,0.488,"anagrelide, GSK256066",0.737548910269571,0.311580177997289,FALSE
+"H1648","Pearson.est","PI3K inhibitor",-0.34815,-0.928,0.521,1265,0.896,"TG.100713, PF.05212384, GDC.0980, GSK2126458, CH5132799, alpelisib, taselisib",0.283162276700476,0.0476919903378748,FALSE
+"H1648","Pearson.est","PLK inhibitor",0.57843,1.37,0.121,379,0.622,"rigosertib, volasertib, GSK461364",0.91721462968355,0.206209615309181,FALSE
+"H1648","Pearson.est","potassium channel blocker",0.52543,1.25,0.184,558,0.488,"meglitinide, dofetilide, mepivacaine, oleoylethanolamide",0.735182176990464,0.311580177997289,FALSE
+"H1648","Pearson.est","PPAR receptor agonist",0.45597,1.1,0.359,698,0.574,"clofibrate, GW.501516, fenofibrate, oleoylethanolamide, S26948, ciprofibrate",0.444905551421681,0.241088107602027,FALSE
+"H1648","Pearson.est","progesterone receptor agonist",0.55625,1.32,0.155,153,0.577,"norethindrone, danazol, tanaproget",0.809668301829709,0.238824186844269,FALSE
+"H1648","Pearson.est","proteasome inhibitor",0.54645,1.31,0.153,536,0.504,"ixazomib, MG.132, delanzomib, oprozomib, bortezomib, ONX.0914",0.815308569182401,0.297569463554475,FALSE
+"H1648","Pearson.est","protein synthesis inhibitor",0.43581,1.06,0.393,336,0.593,"brefeldin.a, mercaptopurine, cycloheximide, homoharringtonine, harringtonine, methacycline, anguidine",0.405607449624573,0.226945306635737,FALSE
+"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.73932,-1.96,0.00687,1418,0.0805,"CP.724714, BMS.599626, AV.412",2.16304326294045,1.09420411963213,TRUE
+"H1648","Pearson.est","RAF inhibitor",0.54133,1.31,0.156,640,0.504,"dabrafenib, vemurafenib, regorafenib, TAK.632, LGX818, GDC.0879, CEP.32496, sorafenib, RAF265, SB.590885, AZ.628",0.806875401645538,0.297569463554475,FALSE
+"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.38665,0.929,0.564,151,0.754,"regorafenib, sunitinib",0.248720896016658,0.122628654130226,FALSE
+"H1648","Pearson.est","retinoid receptor agonist",0.25275,0.6,0.912,137,0.994,"fenretinide",0.0400051616715838,0.00261361560268669,FALSE
+"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.66371,1.57,0.0418,443,0.437,"cladribine, pentostatin, triapine, clofarabine, fludarabine, fludarabine.phosphate, hydroxyurea, LY2334737",1.37882371822496,0.359518563029578,FALSE
+"H1648","Pearson.est","serotonin receptor agonist",0.56884,1.35,0.129,527,0.627,"NAN.190, aripiprazole, SR.57227A, ipsapirone",0.889410289700751,0.202732459169284,FALSE
+"H1648","Pearson.est","serotonin receptor antagonist",0.51875,1.24,0.221,262,0.487,"lerisetron, SB.200646, aripiprazole, paliperidone, pirenperone",0.655607726314889,0.312471038785366,FALSE
+"H1648","Pearson.est","sodium channel blocker",-0.20939,-0.546,0.969,1286,0.997,"A.803467, lappaconite, brivaracetam",0.0136762229492347,0.00130484168834428,FALSE
+"H1648","Pearson.est","src inhibitor",-0.58654,-1.55,0.0629,1332,0.389,"dasatinib, bosutinib, ZM.306416, saracatinib",1.20134935455473,0.410050398674292,FALSE
+"H1648","Pearson.est","sterol demethylase inhibitor",0.5386,1.28,0.181,347,0.49,"ketoconazole, posaconazole, chlormidazole, lanoconazole",0.742321425130815,0.309803919971486,FALSE
+"H1648","Pearson.est","TGF beta receptor inhibitor",-0.38776,-1.06,0.377,1402,0.866,"repsox",0.423658649794207,0.0624821079826534,FALSE
+"H1648","Pearson.est","thymidylate synthase inhibitor",0.42473,1.02,0.444,523,0.629,"ftorafur, trifluridine, doxifluridine, raltitrexed",0.35261702988538,0.201349354554731,FALSE
+"H1648","Pearson.est","topoisomerase inhibitor",0.53522,1.28,0.167,415,0.49,"nemorubicin, etoposide.phosphate, topotecan, teniposide, daunorubicin, voreloxin, doxorubicin, amsacrine, epirubicin, rubitecan, idarubicin, TAS.103, valrubicin, amonafide, etoposide",0.777283528852417,0.309803919971486,FALSE
+"H1648","Pearson.est","tubulin polymerization inhibitor",0.492,1.16,0.29,511,0.515,"verubulin, vinblastine, BNC105, taltobulin, combretastatin.A.4, vindesine, CYT.997, vincristine, plinabulin, KX2.391, fosbretabulin, vinorelbine, podophyllotoxin, dolastatin.10",0.537602002101044,0.288192770958809,FALSE
+"H1648","Pearson.est","tyrosine kinase inhibitor",-0.36687,-0.965,0.48,1415,1,"vandetanib, CP.724714, BMS.599626, AV.412",0.318758762624413,0,FALSE
+"H1648","Pearson.est","VEGFR inhibitor",-0.30751,-0.794,0.652,1411,1,"AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.18575240426808,0,FALSE
+"H1648","Pearson.est","vitamin D receptor agonist",-0.85631,-2.28,0,1299,0.00627,"ercalcitriol, paricalcitol, tacalcitol, calcitriol, maxacalcitol",Inf,2.20273245916928,TRUE
+"H2126","Pearson.est","EGFR inhibitor",-0.83003,-2.18,0,1371,0.0166,"rociletinib, AST.1306, vandetanib, BIBU.1361, afatinib, WZ8040, PD.153035, TAK.285, erlotinib, AEE788, CUDC.101, dacomitinib, ARRY.334543, BMS.599626, BIBX.1382, gefitinib, canertinib, osimertinib, CP.724714, GW.583340, XL.647, poziotinib, PD.168393, BMS.690514, lapatinib, neratinib, AZD8931, tucatinib",Inf,1.77989191195995,TRUE
+"H2126","Pearson.est","Abl kinase inhibitor",0.48701,1.19,0.256,94,0.593,"ponatinib, GZD824, tozasertib, KW.2449",0.59176003468815,0.226945306635737,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",0.31132,0.769,0.766,79,0.882,"oxiracetam",0.115771230367396,0.0545314148681803,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",0.23508,0.583,0.946,216,0.986,"iododexetimide",0.0241088635982073,0.0061230850587888,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.74087,-1.96,0.0119,1390,0.0524,"SCH.58261, MRS.1220, CGS.15943",1.92445303860747,1.28066871301627,TRUE
+"H2126","Pearson.est","adrenergic receptor agonist",0.28732,0.682,0.848,538,0.943,"midodrine, lidamidine, buphenine, clenbuterol, oxymetazoline, terbutaline, ritodrine",0.0716041477432862,0.0254883072626717,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",0.22516,0.549,0.946,499,0.991,"oxprenolol, idazoxan, carvedilol, metoprolol, levobunolol, naftidrofuryl, atipamezole",0.0241088635982073,0.00392634551472468,FALSE
+"H2126","Pearson.est","AKT inhibitor",-0.72093,-1.91,0.00893,1295,0.0523,"triciribine, A.674563, CCT128930, uprosertib, GSK2110183, GDC.0068",2.04914854111145,1.28149831113273,TRUE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41451,0.994,0.475,346,0.784,"lorlatinib, DMH1, AZD3463, alectinib",0.323306390375133,0.105683937315562,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",0.37416,0.909,0.565,505,0.86,"nilutamide, bicalutamide, cyproterone.acetate",0.247951552180562,0.0655015487564323,FALSE
+"H2126","Pearson.est","antioxidant",0.50686,1.23,0.224,594,0.584,"mesna, trolox, benfotiamine, chlorogenic.acid",0.649751981665837,0.233587152887601,FALSE
+"H2126","Pearson.est","AP inhibitor",0.33481,0.811,0.692,593,0.89,"idronoxil, embelin, GDC.0152, LCL.161, birinapant",0.159893905543242,0.0506099933550872,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.41785,1.01,0.454,310,0.775,"ouabain, blebbistatin...., digitoxin, digoxin, thonzonium, digitoxigenin",0.342944147142896,0.11069829749369,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.48142,1.14,0.331,348,0.625,"barasertib, tozasertib, KW.2449, AT.9283, AMG900, SNS.314, PF.03814735, hesperadin, GSK1070916, barasertib.HQPA, alisertib, ENMD.2076",0.480172006224281,0.204119982655925,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.25396,0.611,0.911,153,0.981,"valnemulin",0.0404816230270017,0.0083309926200515,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.38054,0.931,0.525,136,0.862,"sparfloxacin, novobiocin",0.279840696594043,0.0644927341752872,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.39995,0.984,0.492,484,0.78,"venetoclax, obatoclax, TW.37, ABT.737, gossypol",0.30803489723264,0.10790539730952,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.54689,1.32,0.162,397,0.602,"ponatinib, GZD824, tozasertib, nilotinib, flumatinib, bafetinib",0.790484985457369,0.220403508742175,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",0.21028,0.513,0.972,742,0.991,"temazepam, piperazine, indiplon, eprinomectin, zaleplon, gamma.aminobutyric.acid, ivermectin, ZK.93423, CGS.20625",0.0123337350737254,0.00392634551472468,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",-0.8054,-2.13,0,1285,0.0177,"I.BET151, OTX015, JQ1....",Inf,1.75202673363819,TRUE
+"H2126","Pearson.est","calcium channel blocker",-0.36069,-0.952,0.451,1224,0.774,"SKF.96365, SR.33805, fendiline",0.345823458122039,0.111259039317107,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.68157,1.68,0.0214,377,0.319,"UNBS.5162, SB.225002, navarixin, PF.04136309, MK.0812",1.66958622665081,0.496209316942819,FALSE
+"H2126","Pearson.est","CDK inhibitor",-0.24804,-0.666,0.852,1427,0.938,"arcyriaflavin.a, indirubin",0.0695604052332999,0.0277971616209356,FALSE
+"H2126","Pearson.est","CHK inhibitor",0.4989,1.24,0.215,466,0.617,"SCH.900776, LY2606368, PF.477736, SB.218078",0.667561540084395,0.209714835966758,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.17321,-0.466,0.997,1067,0.99,"metoxibutropate, meloxicam, sulfasalazine, AM.404, ramifenazone, aspirin, FK.3311, amfenac, tryptanthrin",0.00130484168834428,0.00436480540245009,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",0.6974,1.72,0.0139,114,0.444,"metyrapone, itraconazole, morin",1.8569851997459,0.35261702988538,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.50166,1.23,0.256,328,0.584,"melphalan, carmustine, carboplatin, temozolomide, estramustine, streptozotocin",0.59176003468815,0.233587152887601,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.3449,0.831,0.68,257,0.877,"melphalan, carmustine, chlorambucil, carboplatin",0.167491087293764,0.0570004066339595,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",-0.31449,-0.823,0.644,1256,0.822,"azacitidine, SGI.1027",0.191114132640188,0.0851281824599496,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",0.4831,1.17,0.277,497,0.586,"trifluridine, idoxuridine, adefovir.dipivoxil, foscarnet",0.557520230935551,0.232102383981909,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",0.41355,1.01,0.439,644,0.775,"nelarabine, anisomycin, floxuridine, cyclocytidine, artesunate, azodicarbonamide, artemisinin, capecitabine, CB.10.277",0.357535479757879,0.11069829749369,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",0.31935,0.793,0.741,160,0.882,"raclopride, paliperidone, amisulpride, isofloxythepin",0.130181792020672,0.0545314148681803,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",0.2636,0.634,0.888,524,0.977,"estrone, PPT, estradiol",0.051587034221399,0.0101054362812269,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",0.34524,0.842,0.642,476,0.879,"toremifene, fulvestrant, raloxifene, danazol",0.192464971931147,0.0560111249262281,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.53259,1.28,0.196,247,0.59,"erdafitinib, dovitinib, MK.2461, regorafenib",0.707743928643524,0.229147988357856,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.57093,1.43,0.114,348,0.491,"ponatinib, gilteritinib, tozasertib, dovitinib, KW.2449, lestaurtinib, sunitinib, midostaurin, tyrphostin.AG.1296, quizartinib, ENMD.2076",0.943095148663527,0.308918507877032,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",-0.30724,-0.808,0.679,1050,0.806,"deflazacort, rimexolone, halobetasol.propionate, betamethasone, beclomethasone.dipropionate, difluprednate, fludroxycortide, halcinonide, flumethasone, methylprednisolone, triamcinolone.acetonide, clobetasol.propionate",0.168130225719498,0.0936649581949093,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.36744,-0.977,0.476,1160,0.779,"CPP, ACDPP, latrepirdine, LY456236, tiletamine, CGP.37849",0.322393047279507,0.108462542327436,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.32802,-0.88,0.538,1431,0.807,"indirubin",0.269217724333611,0.0931264652779296,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.47401,1.13,0.324,261,0.623,"PHA.848125, GSK1838705A, lestaurtinib, AZD3463",0.489454989793388,0.20551195334083,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.48922,1.2,0.267,386,0.596,"narlaprevir, embelin, mericitabine",0.573488738635425,0.224753740259764,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.63626,-1.73,0.0338,1080,0.119,"vorinostat, R306465, panobinostat, scriptaid, AR.42, tacedinaline, romidepsin, PCI.24781, M.344, JNJ.26481585, givinostat, mocetinostat, SB.939, pyroxamide",1.47108329972235,0.924453038607469,TRUE
+"H2126","Pearson.est","histamine receptor antagonist",0.29944,0.719,0.82,302,0.915,"cimetidine, pheniramine, astemizole, tiotidine, famotidine",0.0861861476162833,0.0385789059335517,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",0.91756,2.25,0,14,0,"fluvastatin, atorvastatin, mevastatin, pitavastatin",Inf,Inf,TRUE
+"H2126","Pearson.est","HSP inhibitor",0.45381,1.11,0.361,326,0.642,"SNX.2112, NVP.AUY922, ganetespib, NMS.E973, BIIB021, SNX.5422, PU.H71",0.442492798094342,0.192464971931147,FALSE
+"H2126","Pearson.est","JAK inhibitor",0.35905,0.864,0.633,503,0.902,"tozasertib, AT.9283, lestaurtinib, AZ960, PRT062070, TG.101209, TG.101348",0.198596289982645,0.0447934624580583,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.49951,1.21,0.256,634,0.602,"KI.8751, sunitinib, midostaurin, motesanib, regorafenib, cediranib, pazopanib, lenvatinib, telatinib, dasatinib, sorafenib, OSI.930, masitinib",0.59176003468815,0.220403508742175,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.31739,-0.829,0.669,1421,0.856,"RITA",0.174573882232177,0.0675262353228468,FALSE
+"H2126","Pearson.est","MEK inhibitor",0.32807,0.808,0.671,755,0.876,"PD.318088, U.0126, cobimetinib, AZD8330, PD.0325901, refametinib, TAK.733, Ro.4987655, AS.703026, arctigenin, MEK162, BIX.02188",0.173277479831008,0.0574958938319193,FALSE
+"H2126","Pearson.est","MET inhibitor",-0.4006,-1.03,0.415,1387,0.727,"NVP.BVU972, INC.280",0.381951903287907,0.138465589140962,FALSE
+"H2126","Pearson.est","microtubule inhibitor",0.67524,1.66,0.0368,173,0.208,"vinblastine, vinflunine, podophyllotoxin, cabazitaxel, secnidazole",1.43415218132648,0.681936665037238,TRUE
+"H2126","Pearson.est","mTOR inhibitor",-0.33124,-0.886,0.537,1111,0.847,"XL388, torin.2, voxtalisib, palomid.529, PP242, WYE.125132, PF.05212384, GDC.0980, PI.103, GSK2126458",0.270025714300444,0.0721165896692931,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.18063,-0.478,0.989,1203,1,"Ro.106.9920, EVP4593, tyloxapol",0.0048037084028206,0,FALSE
+"H2126","Pearson.est","opioid receptor agonist",0.56838,1.37,0.131,460,0.52,"spiradoline, cebranopadol, trimebutine, BW.180C",0.882728704344236,0.283996656365201,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",-0.4372,-1.17,0.273,630,0.711,"skepinone.l, TAK.715, CMPD.1, SB.242235, VX.702, talmapimod, SB.239063",0.563837352959244,0.148130399270234,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.5628,1.41,0.102,275,0.5,"talazoparib, niraparib, olaparib",0.991399828238082,0.301029995663981,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.52686,1.27,0.207,548,0.581,"ponatinib, KI.8751, SU014813, axitinib, dovitinib, CP.673451, sunitinib, motesanib, regorafenib, pazopanib, lenvatinib, telatinib, nintedanib, crenolanib, dasatinib, sorafenib",0.684029654543082,0.235823867609669,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.56742,1.39,0.122,97,0.509,"bis.maltolato.oxovanadium.IV., BVT.948, sodium.stibogluconate, GSK2830371",0.913640169325252,0.293282217663241,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",0.40722,1.01,0.462,250,0.775,"anagrelide, GSK256066, YM.976",0.335358024443874,0.11069829749369,FALSE
+"H2126","Pearson.est","PI3K inhibitor",-0.44974,-1.2,0.243,1207,0.732,"CUDC.907, PI3K.IN.2, PI.828, PF.05212384, GDC.0980, PI.103, GSK2126458, CH5132799, alpelisib, taselisib",0.614393726401688,0.135488918941608,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.59805,1.46,0.0655,512,0.464,"rigosertib, GSK461364, volasertib, GW.843682X, HMN.214, BI.2536",1.18375870000822,0.333482019445119,FALSE
+"H2126","Pearson.est","potassium channel blocker",0.30974,0.742,0.793,609,0.901,"dofetilide, mepivacaine, meglitinide",0.100726812682396,0.045275209020937,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",0.3599,0.856,0.646,140,0.895,"fenofibrate",0.189767482004916,0.048176964684088,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",0.3669,0.868,0.626,476,0.916,"norethindrone, tanaproget, danazol",0.20342566678957,0.0381045263321496,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.68299,1.7,0.0141,294,0.357,"ixazomib, bortezomib, delanzomib, MG.132, carfilzomib",1.85078088734462,0.447331783887807,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.49112,1.18,0.264,205,0.589,"brefeldin.a, mercaptopurine, cycloheximide, methacycline, homoharringtonine",0.578396073130169,0.229884705212898,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.75244,-1.93,0.00592,1249,0.0545,"tyrphostin.A9, mubritinib, AV.412, BMS.599626, CP.724714",2.22767829327708,1.26360349772336,TRUE
+"H2126","Pearson.est","RAF inhibitor",0.66605,1.58,0.043,247,0.281,"dabrafenib, vemurafenib, RAF265, GDC.0879, LGX818, AZ.628, regorafenib",1.36653154442041,0.55129368009492,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.31953,0.775,0.739,247,0.89,"sunitinib, regorafenib",0.131355561605174,0.0506099933550872,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.3507,0.851,0.645,234,0.884,"adarotene, tamibarotene",0.190440285364732,0.0535477349869269,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.53448,1.29,0.185,428,0.597,"cladribine, clofarabine, triapine, fludarabine.phosphate, LY2334737, pentostatin, gemcitabine",0.732828271596986,0.224025668870631,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",0.67564,1.67,0.0259,267,0.272,"aripiprazole, NAN.190, ipsapirone, SR.57227A",1.58670023591875,0.565431095965801,FALSE
+"H2126","Pearson.est","serotonin receptor antagonist",0.37798,0.916,0.567,119,0.867,"aripiprazole, lerisetron, paliperidone",0.246416941107093,0.0619809025237897,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.18867,0.455,0.994,516,0.991,"quinidine, mexiletine, benzocaine, mepivacaine",0.00261361560268669,0.00392634551472468,FALSE
+"H2126","Pearson.est","src inhibitor",-0.39411,-1.05,0.361,1411,0.748,"ZM.306416, saracatinib",0.442492798094342,0.126098402135539,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.53761,1.29,0.18,571,0.597,"ketoconazole, posaconazole, lanoconazole, terconazole, chlormidazole",0.744727494896694,0.224025668870631,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",-0.41401,-1.1,0.341,597,0.71,"D.4476, LY2109761, adaprev, SB.525334, SB.431542, repsox",0.467245621007502,0.148741651280925,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.67145,1.63,0.0316,338,0.227,"raltitrexed, trifluridine, carmofur, ftorafur",1.5003129173816,0.643974142806877,TRUE
+"H2126","Pearson.est","topoisomerase inhibitor",0.62204,1.49,0.089,286,0.434,"topotecan, etoposide.phosphate, teniposide, rubitecan, daunorubicin, nemorubicin, irinotecan, doxorubicin, voreloxin, SN.38, TAS.103, etoposide, idarubicin, amsacrine, dexrazoxane",1.05060999335509,0.362510270487489,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.69618,1.66,0.0235,305,0.208,"verubulin, vinblastine, BNC105, taltobulin, vindesine, podophyllotoxin, CYT.997, docetaxel, vincristine, dolastatin.10, combretastatin.A.4, plinabulin, paclitaxel, fosbretabulin, ABT.751, vinorelbine, KX2.391, epothilone.b, indibulin",1.62893213772826,0.681936665037238,TRUE
+"H2126","Pearson.est","tyrosine kinase inhibitor",-0.41526,-1.13,0.278,1320,0.716,"GTP.14564, mubritinib, vandetanib, AV.412, BMS.599626, CP.724714",0.555955204081924,0.145086977692144,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",-0.27477,-0.746,0.796,1382,0.867,"vandetanib, semaxanib, ZM.306416, AEE788, XL.647, BMS.690514",0.0990869322623309,0.0619809025237897,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.82106,-2.23,0,1345,0.0182,"ercalcitriol, paricalcitol, calcitriol, tacalcitol, maxacalcitol",Inf,1.73992861201493,TRUE
+"H520","Pearson.est","EGFR inhibitor",0.72338,1.79,0.0174,130,0.191,"poziotinib, PD.153035, vandetanib, icotinib, erlotinib, pelitinib, XL.647, gefitinib, BIBU.1361, afatinib, dacomitinib, osimertinib, AZD8931, canertinib, lapatinib, AST.1306, neratinib, BMS.599626, PD.168393",1.7594507517174,0.718966632752272,TRUE
+"H520","Pearson.est","Abl kinase inhibitor",0.6975,1.75,0.0153,321,0.197,"dasatinib, bosutinib, ZM.306416, GZD824, metatinib, ponatinib, nilotinib",1.8153085691824,0.705533773838407,TRUE
+"H520","Pearson.est","acetylcholine receptor agonist",0.38711,0.955,0.522,201,0.98,"nicotine, pilocarpine",0.282329496997738,0.00877392430750515,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",-0.38687,-1.01,0.391,1404,0.993,"diphemanil",0.407823242604133,0.00305075150461883,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",0.38874,0.962,0.509,292,1,"PSB.1115, CGS.15943",0.293282217663241,0,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.46375,1.14,0.312,273,0.728,"ritodrine, isoxsuprine, oxymetazoline, buphenine, epinephrine",0.505845405981557,0.137868620686963,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",-0.23295,-0.62,0.907,1066,1,"carvedilol, practolol, propranolol, metoprolol, dihydroergocristine, pindolol",0.0423927129399047,0,FALSE
+"H520","Pearson.est","AKT inhibitor",-0.27207,-0.699,0.802,1177,1,"GSK2110183, ONC201, GDC.0068, A.674563",0.0958256317158365,0,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.2398,0.598,0.917,149,0.985,"lorlatinib, GW.788388",0.0376306643299789,0.00656376950238827,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.29131,0.721,0.823,470,0.965,"RU.58841, nilutamide, bicalutamide",0.0846001647877302,0.0154726866562074,FALSE
+"H520","Pearson.est","antioxidant",0.54097,1.32,0.172,309,0.637,"mesna, chlorogenic.acid",0.764471553092451,0.19586056766465,FALSE
+"H520","Pearson.est","AP inhibitor",0.6253,1.59,0.0516,286,0.311,"birinapant, GDC.0152, LCL.161, embelin",1.28735029837279,0.507239610973163,FALSE
+"H520","Pearson.est","ATPase inhibitor",-0.44657,-1.16,0.287,1201,0.751,"omeprazole, digoxin, evodiamine, rabeprazole, oligomycin.a",0.542118103266008,0.124360062995832,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.65043,-1.67,0.0408,1202,0.429,"PF.03814735, danusertib, AT.9283, SNS.314, PHA.680632, AMG900, aurora.a.inhibitor.i, MK.8745, TAK.901, CCT137690, barasertib.HQPA, barasertib, ZM.447439",1.38933983691012,0.367542707815276,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.38886,0.948,0.496,48,0.956,"tedizolid",0.304518323509803,0.0195421077238999,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.37796,0.939,0.506,14,0.937,"finafloxacin",0.295849483160201,0.0282604091122217,FALSE
+"H520","Pearson.est","BCL inhibitor",-0.37735,-0.965,0.437,1126,0.991,"navitoclax, TW.37, HA14.1, ABT.737, oridonin",0.359518563029578,0.00392634551472468,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.70004,1.74,0.0216,321,0.169,"dasatinib, bosutinib, GZD824, metatinib, ponatinib, nilotinib",1.66554624884907,0.772113295386326,TRUE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.31482,0.782,0.715,329,0.983,"lorazepam, piperazine, eprinomectin, CGS.20625",0.145693958198919,0.00744648216786438,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.72072,-1.92,0.00771,1120,0.35,"bromosporine, I.BET.762, PFI.1, I.BET151, OTX015",2.11294562194904,0.455931955649724,FALSE
+"H520","Pearson.est","calcium channel blocker",0.38857,0.964,0.495,278,1,"SKF.96365, efonidipine.monoethanolate, cinnarazine",0.305394801066431,0,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",0.49066,1.21,0.243,132,0.746,"navarixin, ZK811752",0.614393726401688,0.127261172527331,FALSE
+"H520","Pearson.est","CDK inhibitor",0.21788,0.544,0.949,511,0.956,"AZD5438, alvocidib, palbociclib, kenpaullone, JNJ.7706621, ribociclib, aminopurvalanol.a, AT.7519, PHA.848125, P276.00",0.0227337875727074,0.0195421077238999,FALSE
+"H520","Pearson.est","CHK inhibitor",-0.62331,-1.64,0.0644,1318,0.329,"SB.218078, PF.477736",1.19111413264019,0.482804102050026,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",-0.26361,-0.694,0.798,1342,1,"AM.404, sulfasalazine, naproxen",0.0979971086492706,0,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.62174,1.51,0.0701,268,0.423,"morin, metyrapone, itraconazole",1.15428198203334,0.373659632624958,FALSE
+"H520","Pearson.est","DNA alkylating agent",-0.36093,-0.94,0.498,1273,0.903,"melphalan, satraplatin, dianhydrogalactitol, mitomycin.c",0.302770657240282,0.0443122496864942,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.36156,-0.984,0.462,1166,1,"primaquine, tirapazamine, melphalan, bendamustine, pibenzimol, chlorambucil, valrubicin, mechlorethamine",0.335358024443874,0,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.28711,-0.775,0.728,993,1,"fdcyd, disulfiram, SGI.1027",0.137868620686963,0,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",0.25074,0.622,0.886,304,1,"foscarnet, adefovir.dipivoxil",0.0525662781129492,0,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.31062,-0.811,0.664,1237,1,"estramustine.phosphate, artemisinin, azodicarbonamide, mitomycin.c",0.177831920631982,0,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",0.45375,1.14,0.315,399,0.728,"clebopride, acetophenazine, oxiperomide, isofloxythepin, amisulpride, domperidone, piperacetazine, UH.232....",0.501689446210399,0.137868620686963,FALSE
+"H520","Pearson.est","estrogen receptor agonist",0.23476,0.579,0.927,463,0.978,"erteberel, PPT, estrone, ethinyl.estradiol",0.0329202658555029,0.00966114521239857,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",0.36681,0.909,0.542,221,0.896,"raloxifene, clomifene",0.266000713461613,0.0476919903378748,FALSE
+"H520","Pearson.est","FGFR inhibitor",-0.53967,-1.42,0.118,1255,0.521,"dovitinib, regorafenib, erdafitinib, lenvatinib, nintedanib",0.928117992693875,0.283162276700476,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.23279,-0.612,0.901,913,1,"lestaurtinib, pacritinib, tozasertib, tyrphostin.AG.1296, midostaurin, quizartinib, TG.02, ENMD.2076, sorafenib, dovitinib, TG.101348",0.045275209020937,0,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",0.52123,1.31,0.169,259,0.609,"hydrocortisone, fluocinolone.acetonide, ciclesonide, dexamethasone.acetate, flumethasone.pivalate, triamcinolone.acetonide, halobetasol.propionate, prednisolone.acetate, desonide",0.772113295386326,0.215382707367125,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",0.28854,0.722,0.799,312,0.991,"SIB.1757, diazooxonorleucine, MTPG, latrepirdine",0.0974532206860086,0.00392634551472468,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.36965,0.931,0.548,356,0.885,"LY2090314, tideglusib, kenpaullone, TWS.119",0.261219441515631,0.0530567293021746,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",0.36099,0.869,0.607,53,0.913,"GSK1904529A",0.216811308924742,0.039529222465701,FALSE
+"H520","Pearson.est","HCV inhibitor",0.37946,0.932,0.517,341,0.917,"PSI.7976, embelin, daclatasvir",0.286509456906058,0.0376306643299789,FALSE
+"H520","Pearson.est","HDAC inhibitor",-0.57682,-1.56,0.0765,1052,0.347,"belinostat, nexturastat.a, entinostat, mocetinostat, trichostatin.a, dacinostat, PCI.24781, NSC.3852, RGFP966, ACY.1215, givinostat, SB.939, R306465, vorinostat, resminostat, chidamide, pyroxamide, scriptaid, M.344",1.11633856484638,0.459670525209126,FALSE
+"H520","Pearson.est","histamine receptor antagonist",0.28328,0.726,0.776,426,1,"astemizole, ranitidine, terfenadine, zolantidine, levocetirizine, tecastemizole, cimetidine",0.110138278741812,0,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.53804,1.34,0.159,466,0.708,"lovastatin, fluvastatin, pitavastatin, simvastatin",0.798602875679548,0.149966742310231,FALSE
+"H520","Pearson.est","HSP inhibitor",-0.33422,-0.893,0.547,1439,0.965,"NMS.E973",0.262012673666569,0.0154726866562074,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.21345,-0.575,0.954,1167,0.968,"PRT062070, LY2784544, AT.9283, ruxolitinib, TG.101348",0.0204516252959049,0.0141246426916063,FALSE
+"H520","Pearson.est","KIT inhibitor",0.29841,0.734,0.809,1,1,"dasatinib",0.0920514783877277,0,FALSE
+"H520","Pearson.est","MDM inhibitor",0.47695,1.19,0.267,332,0.744,"idasanutlin, nutlin.3",0.573488738635425,0.128427064454121,FALSE
+"H520","Pearson.est","MEK inhibitor",0.79814,2.02,0.00514,44,0.0597,"TAK.733, AZD8330, trametinib, PD.0325901, cobimetinib, Ro.4987655, refametinib, AS.703026, selumetinib, PD.318088, MEK162",2.28903688100472,1.22402566887063,TRUE
+"H520","Pearson.est","MET inhibitor",-0.28754,-0.741,0.802,1082,1,"NVP.BVU972, INC.280, AMG458",0.0958256317158365,0,FALSE
+"H520","Pearson.est","microtubule inhibitor",-0.39052,-1.02,0.404,1237,1,"estramustine.phosphate, vinflunine, colchicine",0.393618634889395,0,FALSE
+"H520","Pearson.est","mTOR inhibitor",0.54424,1.35,0.162,494,0.757,"WAY.600, torin.1, WYE.354, OSI.027, LY303511, XL388, PP242, GSK2126458, AZD8055, SB.2343, PF.04691502, AZD2014, MLN0128, voxtalisib, LY3023414, ku.0063794, NVP.BEZ235, temsirolimus",0.790484985457369,0.120904120499927,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",-0.23904,-0.612,0.923,1423,1,"BAY.11.7082",0.0347982989740879,0,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.52359,1.33,0.155,288,0.666,"ADL5859, trimebutine, BW.180C",0.809668301829709,0.176525770829699,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",0.2219,0.557,0.939,425,0.97,"TAK.715, VX.702",0.0273344077338891,0.0132282657337552,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.65403,-1.69,0.02,1296,0.514,"PJ.34, olaparib, AZD2461, niraparib, talazoparib",1.69897000433602,0.289036881004724,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.31053,-0.814,0.688,1089,1,"motesanib, sorafenib, trapidil, masitinib, axitinib, dovitinib, regorafenib, linifanib, lenvatinib, pazopanib, nintedanib",0.162411561764489,0,FALSE
+"H520","Pearson.est","phosphatase inhibitor",-0.31279,-0.8,0.668,1034,1,"menadione, AS.1949490, mycophenolate.mofetil, CID.5458317",0.175223537524454,0,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",-0.21295,-0.555,0.956,1373,0.955,"enoximone",0.0195421077238999,0.0199966284162537,FALSE
+"H520","Pearson.est","PI3K inhibitor",0.3208,0.806,0.689,480,1,"TG.100713, LY303511, AZD6482, GSK2126458, SB.2343, buparlisib, PF.04691502, GDC.0941, voxtalisib, LY3023414, NVP.BEZ235, PIK.75",0.161780778092374,0,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.70099,-1.82,0.0217,1189,0.378,"HMN.214, BI.2536, NMS.1286937, volasertib",1.66354026615147,0.422508200162775,FALSE
+"H520","Pearson.est","potassium channel blocker",-0.2982,-0.78,0.714,430,1,"oleoylethanolamide, mepivacaine, meglitinide, ML133, ibutilide, dofetilide",0.146301788223826,0,FALSE
+"H520","Pearson.est","PPAR receptor agonist",-0.51085,-1.35,0.153,1170,0.536,"pterostilbene, clofibrate, ciprofibrate, GW.501516",0.815308569182401,0.27083521030723,FALSE
+"H520","Pearson.est","progesterone receptor agonist",-0.23141,-0.609,0.894,333,0.993,"melengestrol.acetate, nomegestrol.acetate, levonorgestrel, norethindrone, dienogest, tanaproget, norethindrone.acetate, norgestrel, danazol",0.0486624812040823,0.00305075150461883,FALSE
+"H520","Pearson.est","proteasome inhibitor",-0.26018,-0.677,0.848,1096,1,"oprozomib, delanzomib, MG.132",0.0716041477432862,0,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.3581,-0.951,0.483,1246,0.971,"azomycin..2.nitroimidazole., harringtonine, bruceantin, homoharringtonine, clofoctol, anguidine",0.316052869248488,0.0127807700919951,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",0.27985,0.689,0.824,487,0.984,"BMS.599626, PP.121, AV.412, NVP.TAE226",0.0840727883028842,0.00700490156865849,FALSE
+"H520","Pearson.est","RAF inhibitor",0.43296,1.09,0.365,305,0.795,"LGX818, AZ.628, CEP.32496, dabrafenib, vemurafenib, SB.590885",0.437707135543525,0.0996328713435297,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",0.52403,1.3,0.188,17,0.584,"vandetanib",0.72584215073632,0.233587152887601,FALSE
+"H520","Pearson.est","retinoid receptor agonist",-0.49046,-1.25,0.231,1216,0.669,"adarotene, adapalene, bexarotene, fenretinide",0.636388020107856,0.174573882232177,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.60728,-1.6,0.061,1025,0.339,"gemcitabine, cladribine, fludarabine, clofarabine, hydroxyurea, cytarabine, pentostatin",1.21467016498923,0.469800301796918,FALSE
+"H520","Pearson.est","serotonin receptor agonist",-0.52589,-1.39,0.145,1361,0.517,"zolmitriptan, aripiprazole",0.838631997765025,0.286509456906058,FALSE
+"H520","Pearson.est","serotonin receptor antagonist",-0.35474,-0.949,0.506,1447,0.927,"aripiprazole",0.295849483160201,0.0329202658555029,FALSE
+"H520","Pearson.est","sodium channel blocker",-0.22785,-0.604,0.908,1203,0.97,"brivaracetam, triamterene, oxcarbazepine, cibenzoline",0.0419141514789149,0.0132282657337552,FALSE
+"H520","Pearson.est","src inhibitor",0.6866,1.69,0.0371,83,0.202,"dasatinib, PP.2, saracatinib, bosutinib, ZM.306416",1.43062609038495,0.694648630553376,TRUE
+"H520","Pearson.est","sterol demethylase inhibitor",0.36398,0.906,0.552,169,0.871,"sulconazole, terconazole",0.258060922270801,0.0599818449923368,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",0.45947,1.14,0.297,92,0.728,"repsox",0.527243550682788,0.137868620686963,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",0.73357,1.8,0.00984,313,0.269,"carmofur, capecitabine, ftorafur, raltitrexed",2.00700490156866,0.570247719997592,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",-0.62958,-1.65,0.0622,1121,0.376,"amsacrine, irinotecan, genz.644282, dexrazoxane, teniposide, voreloxin, doxorubicin, daunorubicin, mitoxantrone, topotecan, valrubicin, etoposide, amonafide, nemorubicin, etoposide.phosphate, epirubicin",1.20620961530918,0.424812155072339,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.4619,-1.19,0.281,945,0.74,"epothilone.d, dolastatin.10, mebendazole, vindesine, BNC105, vinorelbine, verubulin, fosbretabulin, vincristine, CYT.997, flubendazole, ABT.751, albendazole, combretastatin.A.4, fenbendazole, taltobulin, KX2.391",0.55129368009492,0.130768280269024,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",0.32734,0.803,0.69,126,0.975,"dasatinib, vandetanib, BMS.599626",0.161150909262745,0.0109953843014632,FALSE
+"H520","Pearson.est","VEGFR inhibitor",0.24002,0.599,0.934,178,1,"vandetanib, XL.647, ZM.306416, SU014813, BMS.690514, lucitanib",0.0296531237699066,0,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",0.26865,0.688,0.813,310,0.96,"ercalcitriol, tacalcitol",0.0899094544059319,0.0177287669604316,FALSE
+"H460","Pearson.est","EGFR inhibitor",0.18479,0.566,0.918,1188,1,"tucatinib, BMS.690514, canertinib, AZD8931, tyrphostin.AG.494, lapatinib, FERb.033, neratinib, PD.168393, brigatinib, XL.647, poziotinib, icotinib, ARRY.334543, GW.583340, salvianolic.acid.B, osimertinib, gefitinib, erlotinib, dacomitinib, TAK.285, vandetanib, BIBX.1382, WZ8040, CP.724714, afatinib, WZ.3146, rociletinib, AEE788, tyrphostin.AG.1478, CGP.52411, dovitinib, pelitinib, OSI.420, PD.153035, BMS.599626, CUDC.101, BIBU.1361, CNX.2006, WZ.4002, AST.1306",0.0371573187987575,0,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.41326,-0.993,0.482,792,0.942,"ponatinib, flumatinib, GZD824, metatinib, tozasertib, nilotinib, KW.2449, bosutinib",0.31695296176115,0.0259490972071227,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.32193,-0.785,0.747,755,1,"tremorine, nicotine, pilocarpine, oxiracetam",0.126679398184601,0,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.4896,1.51,0.065,742,0.561,"diphemanil, darifenacin, iododexetimide, dicycloverine, hyoscyamine, methscopolamine",1.18708664335714,0.251037138743839,FALSE
+"H460","Pearson.est","adenosine receptor antagonist",-0.22484,-0.547,0.974,1255,1,"istradefylline",0.0114410431213845,0,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",-0.24893,-0.61,0.935,916,1,"lidamidine, midodrine, oxymetazoline, buphenine, clenbuterol",0.0291883891274822,0,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",-0.46215,-1.12,0.339,1247,0.873,"carvedilol, imiloxan, atipamezole, oxprenolol, vincamine",0.469800301796918,0.0589857562944303,FALSE
+"H460","Pearson.est","AKT inhibitor",0.19385,0.6,0.919,123,1,"GDC.0068, GSK2110183, MK.2206",0.0366844886138887,0,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31824,-0.766,0.804,1441,1,"AZD3463",0.0947439512515487,0,FALSE
+"H460","Pearson.est","androgen receptor antagonist",-0.40086,-0.974,0.498,712,0.89,"cyproterone.acetate, RU.58841, nilutamide",0.302770657240282,0.0506099933550872,FALSE
+"H460","Pearson.est","antioxidant",-0.55753,-1.33,0.122,851,0.598,"rutin, taurine, trolox, chlorogenic.acid, mesna",0.913640169325252,0.223298816011589,FALSE
+"H460","Pearson.est","AP inhibitor",-0.39117,-0.926,0.594,635,0.988,"tanshinone.i, birinapant, embelin, LCL.161",0.226213555018806,0.00524305541237188,FALSE
+"H460","Pearson.est","ATPase inhibitor",-0.37845,-0.917,0.582,939,0.961,"digitoxin, blebbistatin...., evodiamine, digitoxigenin, NMS.873, digoxin",0.235077015350112,0.0172766123314547,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.63544,-1.53,0.0347,1021,0.324,"MK.8745, tozasertib, barasertib, barasertib.HQPA, CCT129202, MLN.8054, KW.2449, CCT137690, MK.5108, alisertib, GSK1070916, PHA.680632, AMG900, ENMD.2076, danusertib, SNS.314, AT.9283, hesperadin, PF.03814735",1.45967052520913,0.489454989793388,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54304,-1.33,0.127,1243,0.598,"tedizolid, radezolid, valnemulin",0.896196279044043,0.223298816011589,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.44114,-1.07,0.389,1438,0.863,"finafloxacin",0.410050398674292,0.0639892042847904,FALSE
+"H460","Pearson.est","BCL inhibitor",-0.44563,-1.08,0.347,1396,0.896,"TW.37, gossypol",0.459670525209126,0.0476919903378748,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.41786,-0.998,0.462,792,0.956,"ponatinib, flumatinib, GZD824, metatinib, tozasertib, nilotinib, bosutinib",0.335358024443874,0.0195421077238999,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.26698,0.813,0.687,117,0.931,"CL.218872, indiplon, bentazepam, nefiracetam",0.16304326294045,0.0310503190186574,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.42727,-1.02,0.432,643,0.92,"OTX015, PFI.1, JQ1...., I.BET.762, bromosporine",0.364516253185088,0.0362121726544447,FALSE
+"H460","Pearson.est","calcium channel blocker",-0.51528,-1.27,0.155,1077,0.706,"cinnarazine, carboxyamidotriazole, mibefradil, tetrandrine",0.809668301829709,0.151195298948196,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.48901,-1.19,0.254,1215,0.761,"ZK811752, SB.225002, navarixin",0.595166283380062,0.118615343229427,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.54832,-1.33,0.115,1126,0.598,"BMS.387032, R547, PHA.793887, aminopurvalanol.a, JNJ.7706621, TG.02, kenpaullone, alvocidib, BMS.265246, ribociclib, abemaciclib, AZD5438, palbociclib",0.939302159646388,0.223298816011589,FALSE
+"H460","Pearson.est","CHK inhibitor",0.4275,1.27,0.22,215,0.571,"PF.477736, SCH.900776, LY2606368, LY2603618",0.657577319177794,0.243363891754152,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.34487,-0.834,0.718,1111,1,"tepoxalin, piroxicam, tryptanthrin, ketoprofen, indoprofen, FR.122047",0.1438755557577,0,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",-0.32168,-0.785,0.773,619,1,"eplerenone, cobicistat, morin, itraconazole",0.111820506081675,0,FALSE
+"H460","Pearson.est","DNA alkylating agent",-0.39955,-0.984,0.484,655,0.913,"dianhydrogalactitol, temozolomide, cyclophosphamide, estramustine, carboplatin, satraplatin, TH.302, streptozotocin, melphalan, carmustine, mitomycin.c",0.315154638355588,0.039529222465701,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.35353,-0.847,0.685,1290,1,"melphalan, teroxirone, carmustine, oxaliplatin",0.164309428507574,0,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.25337,-0.62,0.916,591,1,"disulfiram, fdcyd, azacitidine, RG108, decitabine",0.0381045263321496,0,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",-0.65464,-1.58,0.026,1283,0.303,"foscarnet, trifluridine, idoxuridine",1.58502665202918,0.518557371497695,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.51182,-1.23,0.195,1101,0.711,"artesunate, enocitabine, CB.10.277, floxuridine, mitomycin.c, cyclocytidine, anisomycin",0.709965388637482,0.148130399270234,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",-0.40495,-0.982,0.483,1050,0.894,"amisulpride, piperacetazine, domperidone, mesoridazine, sertindole, raclopride, oxiperomide, paliperidone, UH.232....",0.316052869248488,0.0486624812040823,FALSE
+"H460","Pearson.est","estrogen receptor agonist",0.27473,0.834,0.692,139,0.969,"estradiol.cypionate, equol, levonorgestrel, ethinyl.estradiol",0.159893905543242,0.0136762229492347,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",0.32837,1.01,0.439,4,0.75,"toremifene",0.357535479757879,0.1249387366083,FALSE
+"H460","Pearson.est","FGFR inhibitor",0.33102,1.05,0.326,972,0.74,"erdafitinib, lenvatinib, AZD4547, orantinib, nintedanib, lucitanib, dovitinib, MK.2461, regorafenib, PD.173074",0.486782399932061,0.130768280269024,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.44515,-1.07,0.379,792,0.863,"ponatinib, dovitinib, midostaurin, TG.101348, lestaurtinib, tozasertib, gilteritinib, sunitinib, pacritinib, KW.2449, TG.02, ENMD.2076, quizartinib",0.421360790031928,0.0639892042847904,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",-0.32852,-0.804,0.729,934,1,"desonide, flumethasone.pivalate, fluticasone.propionate, halcinonide, prednisolone, rimexolone, flumethasone, halobetasol.propionate, fluocinolone.acetonide, ciclesonide, hydrocortisone",0.137272471682025,0,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.35052,1.08,0.31,945,0.767,"felbamate, CGP.37849, JNJ.16259685, tiletamine, kynurenic.acid, IEM1754, MTPG, LY456236, CPP, latrepirdine, diazooxonorleucine, ACDPP, SIB.1757",0.508638306165727,0.115204636051019,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.22609,-0.556,0.962,946,1,"TWS.119, tideglusib, kenpaullone",0.0168249279621871,0,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.58048,-1.38,0.104,901,0.648,"PHA.848125, lestaurtinib, GSK1904529A, GSK1838705A, danusertib, AZD3463",0.98296666070122,0.188424994129407,FALSE
+"H460","Pearson.est","HCV inhibitor",-0.43235,-1.05,0.399,1217,0.892,"narlaprevir, mericitabine",0.399027104313252,0.0496351456238769,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.21266,-0.512,0.98,574,0.993,"RGFP966, scriptaid, R306465, resminostat, romidepsin, JNJ.26481585, belinostat, trichostatin.a, AR.42, PCI.24781, RG2833, entinostat, givinostat, SB.939, dacinostat",0.00877392430750515,0.00305075150461883,FALSE
+"H460","Pearson.est","histamine receptor antagonist",-0.21489,-0.523,0.983,763,1,"levocetirizine, nizatidine, terfenadine, zolantidine, astemizole, BF2.649, pheniramine, tiotidine",0.00744648216786438,0,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.55687,1.7,0.0521,645,0.509,"pitavastatin, lovastatin, atorvastatin, mevastatin, fluvastatin, simvastatin",1.28316227670048,0.293282217663241,FALSE
+"H460","Pearson.est","HSP inhibitor",-0.49358,-1.18,0.264,1207,0.757,"ganetespib, SNX.2112, NVP.AUY922, tanespimycin, PU.H71",0.578396073130169,0.120904120499927,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.43913,-1.04,0.423,1041,0.89,"tozasertib, AZD1480, pacritinib, AZ960, WHI.P154, TG.101209, TG.02, AT.9283, filgotinib",0.373659632624958,0.0506099933550872,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.31204,-0.755,0.82,1151,1,"OSI.930, sunitinib, vatalanib, KI.8751",0.0861861476162833,0,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.73615,-1.81,0.00224,1170,0.0784,"RITA, idasanutlin, CGM097, serdemetan, nutlin.3",2.64975198166584,1.10568393731556,TRUE
+"H460","Pearson.est","MEK inhibitor",-0.77946,-1.91,0,1195,0.0811,"arctigenin, cobimetinib, refametinib, PD.198306, MEK162, trametinib, PD.184352, selumetinib, AS.703026, nobiletin, PD.318088, PD.0325901, TAK.733, AZD8330, Ro.4987655",Inf,1.09097914578884,TRUE
+"H460","Pearson.est","MET inhibitor",0.46325,1.47,0.0696,780,0.439,"INC.280, NVP.BVU972, AMG458, PF.04217903, LY2801653, PHA.665752",1.15739076038944,0.357535479757879,FALSE
+"H460","Pearson.est","microtubule inhibitor",-0.71337,-1.72,0.00682,1275,0.148,"cabazitaxel, secnidazole, vinflunine, D.64131, vinblastine, podophyllotoxin",2.16621562534352,0.829738284605043,TRUE
+"H460","Pearson.est","mTOR inhibitor",-0.40351,-0.987,0.497,737,0.932,"palomid.529, torin.2, WYE.125132, voxtalisib, SB.2343, PKI.179, deforolimus, LY303511, GSK2126458, NVP.BEZ235, AZD2014, PP242, WAY.600, AZD8055, MLN0128, XL388, torin.1, WYE.354, ku.0063794",0.303643611266668,0.0305840876460186,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",-0.21219,-0.509,0.977,719,0.979,"Ro.106.9920, parthenolide, bortezomib, betulinic.acid, EVP4593",0.0101054362812269,0.00921730819686218,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.55926,-1.37,0.101,950,0.622,"spiradoline, cebranopadol, salvinorin.a, trimebutine",0.995678626217357,0.206209615309181,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",0.32824,0.98,0.471,975,0.738,"talmapimod, SB.239063, TAK.715, SB.242235, VX.702, CMPD.1, skepinone.l",0.326979092871104,0.131943638176958,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.51074,-1.24,0.186,908,0.72,"AZD2461, niraparib, PJ.34, AG.14361, E7449, talazoparib",0.730487055782084,0.142667503568732,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.25466,-0.615,0.93,742,1,"axitinib, ponatinib, trapidil, dovitinib, regorafenib, CP.673451, SU014813, sunitinib, vatalanib, crenolanib, KI.8751",0.0315170514460649,0,FALSE
+"H460","Pearson.est","phosphatase inhibitor",0.14882,0.434,1,1234,0.995,"menadione, alexidine, BVT.948, AS.1949490, mycophenolate.mofetil, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, mycophenolic.acid, GSK2830371",0,0.00217691925427455,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",0.20376,0.638,0.965,1155,1,"enoximone, trequinsin, avanafil, anagrelide, cilostamide, papaverine, YM.976, zardaverine, GSK256066, EMD.53998",0.0154726866562074,0,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.24808,-0.599,0.934,764,1,"BGT226, voxtalisib, GDC.0941, SB.2343, TG.100713, PKI.179, LY303511, GSK2126458, CUDC.907, NVP.BEZ235, YM.201636, PIK.75, ZSTK.474",0.0296531237699066,0,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.75156,-1.85,0.00554,1083,0.0797,"GW.843682X, BI.2536, NMS.1286937, GSK461364, HMN.214, volasertib, rigosertib",2.25649023527157,1.09854167860389,TRUE
+"H460","Pearson.est","potassium channel blocker",-0.33703,-0.821,0.732,486,1,"dofetilide, meglitinide, mepivacaine, ibutilide, ML133, oleoylethanolamide",0.135488918941608,0,FALSE
+"H460","Pearson.est","PPAR receptor agonist",-0.23955,-0.58,0.944,1015,1,"ciprofibrate, oleoylethanolamide",0.025028005701931,0,FALSE
+"H460","Pearson.est","progesterone receptor agonist",-0.26975,-0.667,0.892,953,1,"dienogest, melengestrol.acetate, tanaproget",0.0496351456238769,0,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.39375,1.2,0.224,881,0.602,"delanzomib, ONX.0914, oprozomib, carfilzomib, ixazomib.citrate, MG.132, bortezomib, ixazomib",0.649751981665837,0.220403508742175,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.63246,-1.55,0.0355,1285,0.324,"emetine, brefeldin.a, mercaptopurine, harringtonine, anguidine, bruceantin, cycloheximide, homoharringtonine",1.44977164694491,0.489454989793388,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.33269,-0.802,0.741,888,1,"mubritinib, BMS.599626, tyrphostin.A9, NVP.TAE226",0.130181792020672,0,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.50483,-1.24,0.201,1105,0.72,"SB.590885, CEP.32496, RAF265, dabrafenib, LGX818, AZ.628, GDC.0879",0.696803942579511,0.142667503568732,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.34496,-0.836,0.705,873,1,"regorafenib, cabozantinib, sunitinib",0.151810883008601,0,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.35923,-0.87,0.655,1392,1,"adarotene",0.183758700008217,0,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.44285,-1.08,0.369,924,0.896,"gemcitabine, cladribine, triapine, clofarabine, LY2334737",0.43297363384094,0.0476919903378748,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.53638,-1.3,0.123,1447,0.652,"aripiprazole",0.910094888560602,0.18575240426808,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.44652,-1.08,0.356,1068,0.896,"pirenperone, sertindole, paliperidone, SB.200646, aripiprazole",0.448550002027125,0.0476919903378748,FALSE
+"H460","Pearson.est","sodium channel blocker",-0.38465,-0.923,0.591,1013,0.971,"triamterene, butamben, mexiletine, benzethonium, ajmaline, A.803467",0.228412519118745,0.0127807700919951,FALSE
+"H460","Pearson.est","src inhibitor",-0.46449,-1.12,0.321,1133,0.873,"KX2.391, PP.2, TG.100572, bosutinib",0.493494967595128,0.0589857562944303,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.30791,-0.75,0.793,444,1,"posaconazole, chlormidazole, sulconazole, terconazole, lanoconazole, ketoconazole",0.100726812682396,0,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",0.42926,1.33,0.149,829,0.575,"LY2109761, SB.431542, repsox, D.4476, SB.525334, adaprev",0.826813731587726,0.24033215531037,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.61761,-1.5,0.0411,1141,0.351,"ftorafur, trifluridine, raltitrexed, carmofur",1.38615817812393,0.454692883534176,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.50043,-1.2,0.243,833,0.767,"irinotecan, nemorubicin, doxorubicin, camptothecin, SN.38, topotecan, exatecan.mesylate, fleroxacin, dexrazoxane, rubitecan, valrubicin, genz.644282, daunorubicin, voreloxin, teniposide, amonafide, idarubicin, amsacrine, TAS.103",0.614393726401688,0.115204636051019,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.66396,-1.59,0.0233,1027,0.338,"mebendazole, oxibendazole, paclitaxel, KX2.391, vindesine, indibulin, vincristine, plinabulin, nocodazole, CYT.997, docetaxel, ABT.751, BNC105, vinorelbine, vinblastine, dolastatin.10, podophyllotoxin, parbendazole, combretastatin.A.4, albendazole, taltobulin, verubulin, epothilone.b, fosbretabulin",1.63264407897398,0.471083299722345,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.2958,-0.717,0.819,873,1,"regorafenib, mubritinib, BMS.599626, cabozantinib, tyrphostin.A9, UNC2250, tivantinib, sunitinib, aminopurvalanol.a, NVP.TAE226",0.0867160982395816,0,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.2665,-0.644,0.92,817,1,"dovitinib, MK.2461, regorafenib, semaxanib, PD.173074, cabozantinib, SU014813, SAR131675, OSI.930, sunitinib, RAF265, vatalanib, TG.100572, ENMD.2076, KI.8751",0.0362121726544447,0,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",-0.35484,-0.852,0.677,847,1,"alfacalcidol, doxercalciferol, tacalcitol, ercalcitriol",0.169411331314856,0,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.8326,2.35,0,121,0.0105,"AZD8931, poziotinib, XL.647, canertinib, neratinib, gefitinib, lapatinib, BMS.690514, dacomitinib, osimertinib, erlotinib, tucatinib, ARRY.334543, afatinib, vandetanib, BMS.599626, PD.168393, CUDC.101, icotinib, WZ8040, AST.1306, pelitinib, BIBU.1361, PD.153035, CP.724714, AEE788, rociletinib, WZ.4002, GW.583340",Inf,1.97881070093006,TRUE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.32189,-0.752,0.804,998,1,"ponatinib, flumatinib, nilotinib, KW.2449, tozasertib, GZD824",0.0947439512515487,0,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.4728,-1.12,0.317,1189,0.73,"xanomeline, oxiracetam",0.498940737782249,0.136677139879544,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",-0.4804,-1.12,0.329,1151,0.73,"methscopolamine, iododexetimide",0.482804102050026,0.136677139879544,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",0.64509,1.76,0.00909,122,0.156,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",2.04143611677803,0.806875401645538,TRUE
+"H1299","Pearson.est","adrenergic receptor agonist",0.2568,0.734,0.824,1080,1,"isoxsuprine, methyldopa, oxymetazoline, isoetharine, ritodrine, norepinephrine, metaraminol, epinephrine, terbutaline, xylazine, A61603, clenbuterol, buphenine, lidamidine, midodrine",0.0840727883028842,0,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",-0.34419,-0.799,0.735,868,1,"pindolol, naftidrofuryl, metoprolol, oxprenolol, atipamezole, vincamine, idazoxan, carvedilol",0.133712660915805,0,FALSE
+"H1299","Pearson.est","AKT inhibitor",0.46108,1.34,0.146,243,0.356,"GDC.0068, uprosertib, CCT128930, GSK2110183, AZD5363, triciribine",0.835647144215563,0.448550002027125,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26514,0.741,0.796,1067,1,"GW.788388, brigatinib, SB.505124, NVP.TAE684, CEP.37440, alectinib, AP26113, AZD3463, crizotinib, DMH1, lorlatinib",0.0990869322623309,0,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",-0.26972,-0.638,0.913,551,0.952,"cyproterone.acetate, RU.58841, bicalutamide, flutamide, nilutamide",0.039529222465701,0.0213630516155257,FALSE
+"H1299","Pearson.est","antioxidant",0.53883,1.49,0.0708,671,0.301,"mesna, taurine, trolox, rutin, chlorogenic.acid, benfotiamine",1.14996674231023,0.521433504406157,FALSE
+"H1299","Pearson.est","AP inhibitor",-0.51716,-1.22,0.224,1012,0.668,"birinapant, GDC.0152, idronoxil",0.649751981665837,0.175223537524454,FALSE
+"H1299","Pearson.est","ATPase inhibitor",-0.71887,-1.69,0.0193,1165,0.122,"evodiamine, digitoxin, ouabain, k.strophanthidin, thonzonium, NMS.873, digitoxigenin, oligomycin.a, digoxin",1.71444269099223,0.913640169325252,TRUE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.64737,-1.55,0.0259,1167,0.31,"ZM.447439, GSK1070916, alisertib, KW.2449, tozasertib, MK.8745, barasertib.HQPA, hesperadin, CCT137690, AT.9283, barasertib, PF.03814735, MK.5108, AMG900, SNS.314, danusertib",1.58670023591875,0.508638306165727,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30244,-0.703,0.847,940,0.993,"josamycin, radezolid, valnemulin",0.0721165896692931,0.00305075150461883,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.31494,-0.749,0.783,702,1,"sparfloxacin, trovafloxacin, sarafloxacin, norfloxacin, lomefloxacin, novobiocin",0.106238237942057,0,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.4493,-1.05,0.419,1229,0.861,"TW.37, gossypol",0.377785977033705,0.0649968485463452,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.37134,-0.875,0.653,998,1,"ponatinib, flumatinib, nilotinib, tozasertib, GZD824",0.185086818724926,0,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.22997,0.661,0.859,1118,1,"CL.218872, gamma.aminobutyric.acid, nefiracetam, piperazine, eprinomectin, lorazepam, zaleplon, bentazepam, CGS.20625, indiplon, ZK.93423, ivermectin, temazepam",0.0660068361687577,0,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",-0.3536,-0.825,0.688,634,1,"I.BET151, OTX015, PFI.1, bromosporine",0.162411561764489,0,FALSE
+"H1299","Pearson.est","calcium channel blocker",-0.33053,-0.765,0.746,1423,1,"carboxyamidotriazole",0.127261172527331,0,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.60278,-1.4,0.0927,913,0.507,"RS.504393, PF.04136309, MK.0812, SB.225002, UNBS.5162",1.0329202658555,0.294992040666664,FALSE
+"H1299","Pearson.est","CDK inhibitor",-0.33829,-0.795,0.743,880,1,"JNJ.7706621, AZD5438, kenpaullone, palbociclib, dinaciclib, R547, PHA.848125, BMS.265246, BMS.387032, indisulam, abemaciclib, PHA.793887",0.129011186239425,0,FALSE
+"H1299","Pearson.est","CHK inhibitor",-0.43828,-1.03,0.442,1191,0.884,"LY2606368, PF.477736",0.354577730650908,0.0535477349869269,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",-0.30549,-0.725,0.813,1096,1,"indoprofen, piroxicam, AM.404, naproxen, suxibuzone, tepoxalin",0.0899094544059319,0,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",-0.38331,-0.895,0.613,929,1,"clotrimazole, cobicistat, metyrapone",0.212539525481585,0,FALSE
+"H1299","Pearson.est","DNA alkylating agent",-0.38587,-0.904,0.615,904,1,"streptozotocin, estramustine, cisplatin, carboplatin, TH.302, dianhydrogalactitol, satraplatin, melphalan",0.211124884224583,0,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.38573,-0.908,0.577,1338,1,"valrubicin, melphalan, chlorambucil",0.238824186844269,0,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",0.24649,0.701,0.825,184,1,"azacitidine, fdcyd",0.0835460514500749,0,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",-0.41626,-0.965,0.52,1159,1,"trifluridine, idoxuridine, cephalomannine",0.283996656365201,0,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",-0.52826,-1.22,0.215,981,0.668,"nelarabine, azodicarbonamide, cyclocytidine, artesunate, enocitabine, cisplatin, CB.10.277, artemisinin, anisomycin",0.667561540084395,0.175223537524454,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",0.21578,0.617,0.916,264,1,"lurasidone, clebopride, domperidone, ziprasidone, remoxipride, acetophenazine, nemonapride, mesoridazine, oxiperomide",0.0381045263321496,0,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",0.29792,0.83,0.668,1019,1,"levonorgestrel, erteberel, ethinyl.estradiol, equol, estradiol.cypionate, PPT, estradiol, estrone",0.175223537524454,0,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.39952,-0.941,0.537,1139,1,"fulvestrant, toremifene",0.270025714300444,0,FALSE
+"H1299","Pearson.est","FGFR inhibitor",-0.50765,-1.19,0.246,1048,0.69,"MK.2461, dovitinib, nintedanib, erdafitinib, regorafenib",0.609064892896621,0.161150909262745,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.49502,-1.17,0.272,998,0.715,"ponatinib, lestaurtinib, TG.101348, dovitinib, KW.2449, tyrphostin.AG.1296, tozasertib, midostaurin, quizartinib, sorafenib",0.565431095965801,0.145693958198919,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",0.15179,0.417,0.991,1232,0.998,"triamcinolone.acetonide, ciclesonide, fludroxycortide, hydrocortisone, desonide, methylprednisolone, betamethasone, difluprednate, flumethasone.pivalate, dexamethasone.acetate, fluocinolone.acetonide, clobetasol.propionate, flumethasone, piretanide, prednisolone.acetate, triamcinolone, halobetasol.propionate, halcinonide, prednisolone, prednisolone.hemisuccinate, beclomethasone.dipropionate, rimexolone, deflazacort, fluticasone.propionate, fluorometholone",0.00392634551472468,0.000869458712628891,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.42771,1.21,0.204,164,0.488,"diazooxonorleucine, latrepirdine, CGP.37849, kynurenic.acid, SIB.1757",0.690369832574101,0.311580177997289,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.27844,-0.66,0.882,926,0.983,"GSK.3.inhibitor.IX, TWS.119, kenpaullone, AZD2858, tideglusib",0.0545314148681803,0.00744648216786438,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",-0.36841,-0.873,0.649,927,1,"GSK1838705A, PHA.848125, lestaurtinib, danusertib",0.187755303199631,0,FALSE
+"H1299","Pearson.est","HCV inhibitor",-0.65176,-1.53,0.0424,1138,0.314,"Ro.9187, mericitabine, narlaprevir",1.37263414340727,0.503070351926785,FALSE
+"H1299","Pearson.est","HDAC inhibitor",-0.30694,-0.727,0.814,760,1,"R306465, ACY.1215, SB.939, trichostatin.a, givinostat, RG2833, AR.42, resminostat, scriptaid, chidamide, dacinostat, entinostat, belinostat",0.0893755951107988,0,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",-0.21575,-0.51,0.976,1180,0.994,"nizatidine, tiotidine, cimetidine",0.0105501823333082,0.00261361560268669,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",-0.84377,-2,0.00124,1408,0.0212,"pitavastatin, fluvastatin, mevastatin, atorvastatin",2.90657831483776,1.67366413907125,TRUE
+"H1299","Pearson.est","HSP inhibitor",-0.64908,-1.52,0.052,1247,0.3,"BIIB021, PU.H71, ganetespib, SNX.2112, NVP.AUY922, NMS.E973",1.2839966563652,0.522878745280338,FALSE
+"H1299","Pearson.est","JAK inhibitor",-0.36124,-0.849,0.67,1039,1,"lestaurtinib, TG.101348, AZ960, PRT062070, tozasertib, AT.9283",0.173925197299174,0,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.5337,-1.25,0.191,1107,0.656,"cediranib, OSI.930, motesanib, vatalanib, midostaurin, sorafenib, KI.8751, regorafenib, pazopanib",0.718966632752272,0.18309616062434,FALSE
+"H1299","Pearson.est","MDM inhibitor",-0.28205,-0.657,0.882,1222,0.968,"serdemetan",0.0545314148681803,0.0141246426916063,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.66475,2.05,0.00518,168,0.0514,"trametinib, AS.703026, selumetinib, cobimetinib, AZD8330, PD.0325901, TAK.733, Ro.4987655, MEK162, PD.318088, PD.198306, MEK1.2.inhibitor",2.28567024025477,1.28903688100472,TRUE
+"H1299","Pearson.est","MET inhibitor",-0.2762,-0.647,0.903,955,0.96,"AMG458, PHA.665752, LY2801653",0.0443122496864942,0.0177287669604316,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.72772,-1.7,0.00855,1273,0.133,"D.64131, podophyllotoxin, secnidazole, cabazitaxel, vinflunine, vinblastine",2.06803388527183,0.876148359032914,TRUE
+"H1299","Pearson.est","mTOR inhibitor",0.16318,0.456,1,1022,1,"GSK2126458, GDC.0980, LY303511, WYE.125132, voxtalisib, WAY.600, PP242, XL388, PI.103, OSI.027, torin.2, PF.04691502, SB.2343, everolimus, WYE.354, palomid.529, AZD2014, torin.1, AZD8055, temsirolimus, PF.05212384, MLN0128, NVP.BEZ235, ku.0063794, sirolimus, PKI.179, LY3023414",0,0,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.32517,-0.773,0.786,613,1,"curcumin, parthenolide...., bindarit, BAY.11.7082, betulinic.acid, bortezomib, parthenolide, IKK.2.inhibitor.V, EVP4593",0.104577453960592,0,FALSE
+"H1299","Pearson.est","opioid receptor agonist",-0.39109,-0.916,0.587,754,1,"salvinorin.a, trimebutine, cebranopadol, spiradoline",0.231361898752386,0,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",0.47606,1.39,0.0878,762,0.328,"SB.239063, talmapimod, SB.242235, TAK.715, skepinone.l, VX.702, CMPD.1",1.0565054840939,0.484126156288321,FALSE
+"H1299","Pearson.est","PARP inhibitor",-0.49206,-1.15,0.303,728,0.707,"PJ.34, niraparib, AG.14361, E7449, olaparib, AZD2461, talazoparib",0.518557371497695,0.150580586203101,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.55223,-1.3,0.145,1131,0.588,"trapidil, motesanib, SU014813, dovitinib, nintedanib, vatalanib, axitinib, crenolanib, CP.673451, sorafenib, KI.8751, regorafenib, pazopanib",0.838631997765025,0.230622673923862,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.40347,-0.925,0.587,935,1,"AS.1949490, BVT.948, CID.5458317, GSK2830371, bis.maltolato.oxovanadium.IV.",0.231361898752386,0,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",-0.28672,-0.68,0.864,962,0.982,"papaverine, zardaverine, YM.976, GSK256066",0.0634862575211067,0.00788851221305034,FALSE
+"H1299","Pearson.est","PI3K inhibitor",0.32666,0.883,0.553,92,1,"alpelisib, taselisib, GSK2126458, CH5132799, PI.828",0.257274868695302,0,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.81124,-1.88,0.00124,1169,0.0515,"GW.843682X, HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib",2.90657831483776,1.28819277095881,TRUE
+"H1299","Pearson.est","potassium channel blocker",-0.50625,-1.19,0.245,850,0.69,"ibutilide, meglitinide, mepivacaine, dofetilide",0.610833915635468,0.161150909262745,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",-0.35854,-0.833,0.71,809,1,"ciprofibrate, clofibrate, GW.501516",0.148741651280925,0,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.18348,-0.435,0.994,799,0.994,"norgestrel, norethindrone, dienogest, tanaproget",0.00261361560268669,0.00261361560268669,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.59536,-1.38,0.0978,967,0.522,"bortezomib, ONX.0914, delanzomib, carfilzomib, ixazomib, MG.132",1.0096611452124,0.282329496997738,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.56802,-1.34,0.131,1206,0.515,"puromycin, cycloheximide, bruceantin, thiostrepton, harringtonine, mercaptopurine, homoharringtonine, anguidine",0.882728704344236,0.288192770958809,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.42594,1.19,0.219,72,0.473,"BMS.599626, AV.412, CP.724714",0.659555885159882,0.325138859262188,FALSE
+"H1299","Pearson.est","RAF inhibitor",-0.58449,-1.37,0.116,1250,0.508,"TAK.632, PLX.4720, RAF265, sorafenib, regorafenib",0.935542010773082,0.294136287716081,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.45537,-1.06,0.406,1345,0.866,"sorafenib, regorafenib",0.391473966422806,0.0624821079826534,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",0.31621,0.873,0.607,61,1,"CD.437, tamibarotene",0.216811308924742,0,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.59692,-1.41,0.0929,1302,0.527,"triapine, pentostatin, gemcitabine, cladribine, clofarabine",1.03198428600636,0.278189384787453,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",-0.55047,-1.28,0.185,1305,0.609,"pardoprunox, aripiprazole",0.732828271596986,0.215382707367125,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",-0.49817,-1.16,0.289,1316,0.71,"paliperidone, lerisetron, aripiprazole",0.539102157243452,0.148741651280925,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.5799,-1.36,0.138,971,0.496,"quinidine, mepivacaine, butamben, brivaracetam, triamterene, cibenzoline, benzethonium",0.860120913598763,0.304518323509803,FALSE
+"H1299","Pearson.est","src inhibitor",0.62004,1.74,0.0249,41,0.134,"saracatinib, dasatinib, ZM.306416",1.60380065290426,0.872895201635192,TRUE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.30205,-0.712,0.834,738,1,"lanoconazole, ketoconazole, posaconazole, chlormidazole",0.0788339493622613,0,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",0.51299,1.43,0.0931,227,0.317,"repsox, LY2109761, SB.431542",1.03105031901866,0.498940737782249,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",-0.27336,-0.636,0.894,664,0.937,"ftorafur, doxifluridine, raltitrexed, trifluridine",0.0486624812040823,0.0282604091122217,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.79476,-1.84,0.0025,1234,0.05,"genz.644282, amonafide, dexrazoxane, amsacrine, SN.38, nemorubicin, valrubicin, idarubicin, irinotecan, mitoxantrone, voreloxin, doxorubicin, epirubicin, TAS.103, rubitecan, etoposide, etoposide.phosphate, daunorubicin, teniposide, topotecan",2.60205999132796,1.30102999566398,TRUE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.77033,-1.82,0.00854,1175,0.0513,"parbendazole, mebendazole, epothilone.d, epothilone.b, albendazole, fenbendazole, plinabulin, fosbretabulin, ABT.751, dolastatin.10, podophyllotoxin, vinorelbine, KX2.391, CYT.997, paclitaxel, docetaxel, combretastatin.A.4, vincristine, vindesine, verubulin, taltobulin, BNC105, vinblastine",2.068542129311,1.28988263488818,TRUE
+"H1299","Pearson.est","tyrosine kinase inhibitor",0.26174,0.74,0.807,72,1,"vandetanib, BMS.599626, dasatinib, AV.412, CP.724714",0.0931264652779296,0,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.2861,-0.682,0.869,1048,0.998,"MK.2461, SAR131675, cediranib, OSI.930, motesanib, SU014813, dovitinib, nintedanib, vatalanib, tivozanib, axitinib, RAF265, sorafenib, KI.8751, regorafenib, pazopanib",0.0609802235513335,0.000869458712628891,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.73963,2.15,0,144,0.0363,"maxacalcitol, paricalcitol, tacalcitol",Inf,1.44009337496389,TRUE
+"HCC44","Pearson.est","EGFR inhibitor",-0.74153,-1.74,0.00917,1369,0.257,"WZ.4002, PD.168393, BMS.690514, BMS.599626, CUDC.101, icotinib, BIBU.1361, vandetanib, canertinib, lapatinib, PD.153035, osimertinib, neratinib, AST.1306, AZD8931, dacomitinib, pelitinib, gefitinib, afatinib, erlotinib, XL.647, poziotinib",2.03763066432998,0.590066876668705,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",-0.60626,-1.4,0.106,1396,0.58,"ZM.306416, bosutinib, dasatinib",0.97469413473523,0.236572006437063,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",0.19626,0.54,0.956,1165,0.971,"nefiracetam, xanomeline, oxiracetam, nicotine, tremorine, pilocarpine",0.0195421077238999,0.0127807700919951,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",0.51275,1.45,0.0855,347,0.906,"diphemanil, iododexetimide, darifenacin, methscopolamine",1.06803388527183,0.0428718023231869,FALSE
+"HCC44","Pearson.est","adenosine receptor antagonist",-0.63517,-1.49,0.0571,1352,0.582,"PSB.1115, CGS.15943",1.24336389175415,0.235077015350112,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.29171,-0.672,0.874,1217,1,"isoxsuprine, ritodrine, oxymetazoline",0.058488567365597,0,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",-0.21931,-0.515,0.965,922,1,"atenolol......, idazoxan, vincamine, atipamezole, naftidrofuryl, imiloxan, dronedarone",0.0154726866562074,0,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.41692,-0.962,0.515,953,0.893,"palomid.529, uprosertib, AZD5363, AT7867, triciribine",0.288192770958809,0.0491485411114536,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.37021,-0.86,0.668,822,1,"alectinib, lorlatinib, SB.505124, GW.788388, AP26113, AZD3463",0.175223537524454,0,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",0.24856,0.711,0.824,237,1,"flutamide, enzalutamide",0.0840727883028842,0,FALSE
+"HCC44","Pearson.est","antioxidant",-0.5485,-1.28,0.191,1398,0.542,"mesna",0.718966632752272,0.266000713461613,FALSE
+"HCC44","Pearson.est","AP inhibitor",0.25515,0.725,0.811,68,1,"idronoxil",0.090979145788844,0,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",0.32566,0.894,0.546,183,1,"oligomycin.a, omeprazole, rabeprazole",0.262807357295263,0,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.31183,-0.716,0.815,968,1,"hesperadin, CCT129202, MK.5108, danusertib, ENMD.2076, alisertib, CYC116, PHA.680632, GSK1070916",0.0888423912600234,0,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.58114,-1.36,0.124,912,0.647,"dirithromycin, azalomycin.b, azithromycin, tilmicosin, radezolid, valnemulin, tedizolid",0.906578314837765,0.1890957193313,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.45392,-1.08,0.358,1422,0.885,"finafloxacin",0.446116973356126,0.0530567293021746,FALSE
+"HCC44","Pearson.est","BCL inhibitor",0.39765,1.09,0.286,116,0.836,"oridonin, ABT.737, HA14.1",0.543633966870957,0.0777937225609836,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.55572,-1.31,0.137,1407,0.561,"bosutinib, dasatinib",0.863279432843593,0.251037138743839,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.23279,-0.544,0.957,961,1,"CGS.20625, zaleplon, ZK.93423, eprinomectin, lorazepam, ivermectin",0.0190880622231565,0,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",0.30236,0.855,0.61,1012,0.99,"PFI.1, I.BET151, OTX015, I.BET.762, bromosporine, JQ1....",0.214670164989233,0.00436480540245009,FALSE
+"HCC44","Pearson.est","calcium channel blocker",-0.44882,-1.06,0.389,1228,0.901,"SKF.96365, cinnarazine, tetrandrine",0.410050398674292,0.045275209020937,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.43962,-1.02,0.426,1337,0.903,"navarixin, ZK811752",0.370590400897281,0.0443122496864942,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.57439,-1.33,0.149,1116,0.547,"BMS.387032, kenpaullone, palbociclib, PHA.848125, P276.00, BMS.265246, JNJ.7706621, aminopurvalanol.a, AT.7519, alvocidib, AZD5438",0.826813731587726,0.262012673666569,FALSE
+"HCC44","Pearson.est","CHK inhibitor",0.23084,0.64,0.91,62,0.971,"PF.477736",0.0409586076789064,0.0127807700919951,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",0.30121,0.84,0.602,101,0.964,"naproxen, AM.404, sulfasalazine, metoxibutropate, suxibuzone",0.220403508742175,0.0159229660971692,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.48228,-1.13,0.308,1082,0.821,"morin, eplerenone, itraconazole",0.511449283499556,0.0856568428805592,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",-0.25409,-0.594,0.921,959,1,"estramustine, streptozotocin, dacarbazine, temozolomide, cyclophosphamide, carmustine",0.0357403698031511,0,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.22682,-0.528,0.971,849,1,"primaquine, busulfan, nimorazole, oxaliplatin, teroxirone, metronidazole, sangivamycin, carmustine",0.0127807700919951,0,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.57187,-1.33,0.146,1309,0.547,"azacitidine, decitabine",0.835647144215563,0.262012673666569,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.53296,-1.27,0.182,1032,0.535,"foscarnet, cidofovir, trifluridine, adefovir.dipivoxil, idoxuridine",0.739928612014925,0.271646217978772,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",-0.27393,-0.641,0.89,1149,1,"capecitabine, cyclocytidine, CB.10.277, anisomycin",0.0506099933550872,0,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.44209,-1.03,0.451,1063,0.911,"piperacetazine, UH.232...., domperidone, clebopride, oxiperomide, acetophenazine, mesoridazine",0.345823458122039,0.0404816230270017,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",-0.24876,-0.587,0.936,948,1,"ethinyl.estradiol, estrone, PPT, erteberel",0.0287241512618947,0,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",0.33989,0.929,0.516,158,1,"toremifene, danazol",0.287350298372789,0,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",0.4823,1.34,0.148,284,0.788,"erdafitinib, nintedanib, lenvatinib, dovitinib, orantinib, regorafenib",0.829738284605043,0.103473782510445,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.21355,-0.498,0.98,893,0.997,"TG.02, GTP.14564, tandutinib, ENMD.2076, pacritinib, gilteritinib",0.00877392430750515,0.00130484168834428,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.66066,-1.53,0.0501,1182,0.549,"difluprednate, prednisolone.acetate, halcinonide, rimexolone, dexamethasone.acetate, flumethasone.pivalate, flumethasone, methylprednisolone, desonide, halobetasol.propionate, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, hydrocortisone",1.30016227413275,0.260427655549908,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",-0.27592,-0.636,0.873,1249,1,"diazooxonorleucine, SIB.1757",0.0589857562944303,0,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.26783,-0.62,0.909,1089,1,"TWS.119, kenpaullone, LY2090314",0.0414361167780325,0,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.57476,-1.35,0.139,1015,0.623,"danusertib, GSK1838705A, PHA.848125, AZD3463, GSK1904529A",0.856985199745905,0.20551195334083,FALSE
+"HCC44","Pearson.est","HCV inhibitor",-0.36096,-0.851,0.67,1109,1,"embelin, PSI.7976",0.173925197299174,0,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",0.31392,0.886,0.553,224,0.977,"mocetinostat, pyroxamide, vorinostat, ACY.1215, scriptaid, chidamide, resminostat, M.344",0.257274868695302,0.0101054362812269,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",-0.41138,-0.953,0.519,1020,0.886,"zolantidine, pheniramine, levocetirizine, ebastine, terfenadine, ranitidine, astemizole",0.284832642151542,0.0525662781129492,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",0.75935,2.11,0.00858,60,0.132,"mevastatin, pitavastatin, atorvastatin",2.06651271215129,0.87942606879415,TRUE
+"HCC44","Pearson.est","HSP inhibitor",-0.4145,-0.969,0.523,904,0.905,"tanespimycin, XL888, ganetespib, NVP.AUY922, SNX.2112, SNX.5422, PU.H71, BIIB021",0.281498311132726,0.0433514207947967,FALSE
+"HCC44","Pearson.est","JAK inhibitor",-0.33483,-0.787,0.741,871,1,"baricitinib, atiprimod, TG.02, AZ960, CEP.33779, AZD1480, TG.101209, pacritinib, WHI.P154, filgotinib",0.130181792020672,0,FALSE
+"HCC44","Pearson.est","KIT inhibitor",-0.25412,-0.601,0.92,1436,1,"dasatinib",0.0362121726544447,0,FALSE
+"HCC44","Pearson.est","MDM inhibitor",0.26283,0.768,0.715,1069,1,"AMG.232, serdemetan, CGM097, idasanutlin, nutlin.3, RITA",0.145693958198919,0,FALSE
+"HCC44","Pearson.est","MEK inhibitor",-0.77406,-1.8,0.00785,1295,0.295,"PD.184352, MEK162, refametinib, PD.318088, selumetinib, cobimetinib, Ro.4987655, AS.703026, PD.0325901, TAK.733, trametinib, AZD8330",2.10513034325475,0.530177984021837,FALSE
+"HCC44","Pearson.est","MET inhibitor",-0.36281,-0.844,0.671,992,1,"PHA.665752, LY2801653, PF.04217903",0.173277479831008,0,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",-0.27379,-0.641,0.886,954,1,"D.64131, cabazitaxel, vinblastine, cytochalasin.b, podophyllotoxin",0.0525662781129492,0,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",-0.39847,-0.932,0.566,1069,0.906,"voxtalisib, torin.1, PF.04691502, LY303511, OSI.027, AZD8055, PP242, XL388, WAY.600, WYE.354, GSK2126458",0.247183568811729,0.0428718023231869,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",-0.18799,-0.439,0.986,900,0.993,"EVP4593, bortezomib, curcumin, BAY.11.7085, betulinic.acid",0.0061230850587888,0.00305075150461883,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.42135,-0.995,0.494,652,0.904,"spiradoline, ADL5859, salvinorin.a, cebranopadol, trimebutine",0.306273051076353,0.0438315695246367,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",-0.55789,-1.29,0.174,809,0.547,"SB.242235, skepinone.l, VX.702, SB.239063, CMPD.1, TAK.715",0.7594507517174,0.262012673666569,FALSE
+"HCC44","Pearson.est","PARP inhibitor",0.2542,0.687,0.85,342,0.953,"AZD2461, olaparib, talazoparib, PJ.34",0.0705810742857073,0.0209070993616736,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.33372,0.915,0.538,290,1,"nintedanib, lenvatinib, pazopanib, linifanib, motesanib, axitinib, dovitinib, trapidil, orantinib, sorafenib, regorafenib, telatinib",0.269217724333611,0,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",0.35989,1,0.427,228,0.986,"bis.maltolato.oxovanadium.IV., BVT.948, menadione, CID.5458317",0.369572124974976,0.0061230850587888,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",0.2223,0.617,0.902,13,0.953,"enoximone",0.0447934624580583,0.0209070993616736,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",-0.47286,-1.11,0.324,941,0.84,"PIK.75, CH5132799, YM.201636, voxtalisib, PF.04691502, AZD6482, LY303511, buparlisib, taselisib, GDC.0941, alpelisib, TG.100713, GSK2126458",0.489454989793388,0.0757207139381184,FALSE
+"HCC44","Pearson.est","PLK inhibitor",-0.45064,-1.05,0.377,772,0.892,"BI.2536, GSK461364, GW.843682X, rigosertib, NMS.1286937",0.423658649794207,0.0496351456238769,FALSE
+"HCC44","Pearson.est","potassium channel blocker",0.25104,0.704,0.81,1086,0.97,"dofetilide, mepivacaine, meglitinide, ibutilide, ML133, oleoylethanolamide",0.0915149811213502,0.0132282657337552,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",0.51969,1.48,0.0991,178,1,"GW.501516, clofibrate, pterostilbene",1.00392634551472,0,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",0.49856,1.42,0.125,158,0.753,"norethindrone.acetate, norethindrone, norgestrel, danazol",0.903089986991944,0.123205023799299,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",0.41544,1.12,0.311,261,0.846,"delanzomib, ONX.0914, oprozomib, MG.132",0.507239610973163,0.0726296369609765,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",-0.33274,-0.78,0.747,786,1,"tedizolid.phosphate, florfenicol, chloramphenicol.palmitate, homoharringtonine, bruceantin, thiostrepton, emetine, cycloheximide, brefeldin.a",0.126679398184601,0,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.56854,-1.34,0.148,1374,0.603,"NVP.TAE226, BMS.599626, AV.412",0.829738284605043,0.219682687859849,FALSE
+"HCC44","Pearson.est","RAF inhibitor",-0.31407,-0.741,0.806,1014,1,"LGX818, CEP.32496, SB.590885, AZ.628",0.0936649581949093,0,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.6037,-1.41,0.109,1418,0.787,"vandetanib",0.962573502059376,0.104025267640935,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",0.43741,1.25,0.189,149,0.86,"fenretinide, adapalene, LE.135, bexarotene",0.723538195826756,0.0655015487564323,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.44038,1.21,0.22,250,0.831,"pentostatin, cladribine, hydroxyurea, fludarabine",0.657577319177794,0.080398976215889,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.42138,-0.993,0.484,1286,0.879,"ipsapirone",0.315154638355588,0.0560111249262281,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.42529,-0.996,0.473,1072,0.932,"SB.216641, pirenperone, RS.16566, SB.228357",0.325138859262188,0.0305840876460186,FALSE
+"HCC44","Pearson.est","sodium channel blocker",0.25567,0.716,0.803,25,1,"cibenzoline, oxcarbazepine",0.095284454721319,0,FALSE
+"HCC44","Pearson.est","src inhibitor",-0.73033,-1.7,0.0117,1268,0.186,"PP.2, ZM.306416, bosutinib, saracatinib, dasatinib",1.93181413825384,0.730487055782084,TRUE
+"HCC44","Pearson.est","sterol demethylase inhibitor",0.41401,1.18,0.242,259,0.796,"chlormidazole, ketoconazole, posaconazole",0.616184634019569,0.0990869322623309,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.60439,-1.4,0.0913,1175,0.58,"D.4476, repsox",1.0395292224657,0.236572006437063,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.73496,-1.72,0.00789,1138,0.204,"trifluridine, capecitabine, ftorafur, raltitrexed, carmofur",2.10292299679058,0.690369832574101,TRUE
+"HCC44","Pearson.est","topoisomerase inhibitor",-0.34027,-0.783,0.742,1124,1,"amsacrine, camptothecin, TAS.103, licochalcone.a, SN.38, idarubicin, exatecan.mesylate, fleroxacin",0.129596094720973,0,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.5069,-1.21,0.263,963,0.648,"vinblastine, dolastatin.10, vinorelbine, verubulin, plinabulin, paclitaxel, albendazole, oxibendazole, fosbretabulin, docetaxel, indibulin, podophyllotoxin, epothilone.b, parbendazole, nocodazole",0.580044251510242,0.188424994129407,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.55477,-1.29,0.175,1336,0.547,"aminopurvalanol.a, NVP.TAE226, tivantinib, BMS.599626, AV.412, vandetanib, dasatinib",0.756961951313706,0.262012673666569,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",-0.30144,-0.71,0.83,1391,1,"BMS.690514, ZM.306416, vandetanib, XL.647",0.0809219076239261,0,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",-0.59072,-1.4,0.109,1126,0.58,"alfacalcidol, ercalcitriol, tacalcitol",0.962573502059376,0.236572006437063,FALSE
+"A549","Pearson.est","EGFR inhibitor",-0.2672,-0.658,0.889,795,1,"ARRY.334543, tyrphostin.AG.494, CNX.2006, BMS.690514, dacomitinib, poziotinib, gefitinib, vandetanib, XL.647, afatinib, PD.153035, WZ8040, tyrphostin.AG.1478, pelitinib, PD.168393, erlotinib, OSI.420, icotinib, WZ.4002, BMS.599626",0.0510982390297863,0,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",-0.57696,-1.42,0.0984,1115,0.573,"KW.2449, flumatinib, GZD824, ponatinib, nilotinib, metatinib, bosutinib, dasatinib",1.00700490156866,0.24184537803261,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",-0.24936,-0.616,0.911,672,1,"tremorine, nicotine, pilocarpine",0.0404816230270017,0,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",0.28502,0.834,0.658,1037,0.775,"diphemanil, iododexetimide, hyoscyamine, darifenacin, dicycloverine, methscopolamine",0.181774106386044,0.11069829749369,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.26509,0.825,0.677,1066,0.745,"MRS.1220, SCH.58261, istradefylline, CGS.15943, sulmazole, theophylline, PSB.1115",0.169411331314856,0.127843727251707,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",-0.31283,-0.759,0.774,1030,1,"oxymetazoline, isoetharine, midodrine, buphenine, clenbuterol, isoxsuprine",0.111259039317107,0,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",-0.38915,-0.962,0.515,788,0.978,"prazosin, oxprenolol, RS.17053, carvedilol, pindolol, idazoxan, naftidrofuryl, dronedarone, imiloxan, vincamine, levobunolol, atipamezole",0.288192770958809,0.00966114521239857,FALSE
+"A549","Pearson.est","AKT inhibitor",0.39772,1.21,0.214,110,0.471,"GDC.0068, uprosertib, GSK2110183, MK.2206",0.669586226650809,0.326979092871104,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4207,-1.03,0.413,1444,0.95,"AZD3463",0.384049948343599,0.0222763947111523,FALSE
+"A549","Pearson.est","androgen receptor antagonist",-0.77344,-1.89,0.0024,1389,0.147,"nilutamide, cyproterone.acetate, RU.58841",2.61978875828839,0.832682665251824,TRUE
+"A549","Pearson.est","antioxidant",-0.59613,-1.47,0.0595,909,0.623,"taurine, chlorogenic.acid, mesna, trolox, rutin",1.22548303427145,0.20551195334083,FALSE
+"A549","Pearson.est","AP inhibitor",0.53398,1.57,0.0391,678,0.187,"embelin, idronoxil, tanshinone.i, birinapant, GDC.0152, LCL.161",1.40782324260413,0.728158393463501,TRUE
+"A549","Pearson.est","ATPase inhibitor",-0.5111,-1.26,0.201,1119,0.812,"digitoxin, digoxin, blebbistatin...., ouabain, digitoxigenin",0.696803942579511,0.0904439707588247,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.29338,-0.729,0.819,884,0.998,"MK.5108, hesperadin, SNS.314, alisertib, MLN.8054, KW.2449, CYC116, AT.9283, CCT129202, AMG900, PF.03814735",0.0867160982395816,0.000869458712628891,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.5828,-1.46,0.0896,1089,0.579,"tilmicosin, dirithromycin, valnemulin, radezolid, tedizolid",1.04769199033787,0.237321436272564,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.48335,-1.19,0.256,1433,0.849,"finafloxacin",0.59176003468815,0.0710923097560473,FALSE
+"A549","Pearson.est","BCL inhibitor",0.27012,0.791,0.749,133,0.756,"ABT.737, oridonin, HA14.1",0.125518182300534,0.121478204498793,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.63302,-1.56,0.0375,1144,0.83,"flumatinib, GZD824, ponatinib, nilotinib, metatinib, bosutinib, dasatinib",1.42596873227228,0.0809219076239261,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",-0.3097,-0.761,0.781,1161,1,"lorazepam, CGS.20625, ivermectin, eprinomectin",0.1073489661227,0,FALSE
+"A549","Pearson.est","bromodomain inhibitor",0.85058,2.55,0,190,0.00497,"I.BET151, OTX015, PFI.1, JQ1...., I.BET.762",Inf,2.30364361126667,TRUE
+"A549","Pearson.est","calcium channel blocker",-0.20252,-0.499,0.988,1312,0.978,"cinnarazine",0.00524305541237188,0.00966114521239857,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",-0.39894,-0.992,0.494,1406,0.931,"navarixin",0.306273051076353,0.0310503190186574,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.54502,-1.35,0.122,1097,0.576,"CR8..R., NU6027, aminopurvalanol.a, JNJ.7706621, R547, abemaciclib, kenpaullone, PHA.848125, palbociclib, AZD5438, BMS.265246",0.913640169325252,0.239577516576788,FALSE
+"A549","Pearson.est","CHK inhibitor",0.51839,1.55,0.0517,11,0.152,"PF.477736",1.28650945690606,0.818156412055227,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",-0.24007,-0.585,0.95,947,1,"piroxicam, meloxicam, acetylsalicylsalicylic.acid, tepoxalin, FR.122047, ketoprofen, indoprofen, tryptanthrin",0.0222763947111523,0,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",-0.58287,-1.44,0.078,934,0.574,"metyrapone, cobicistat, eplerenone, itraconazole",1.10790539730952,0.241088107602027,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.44312,-1.1,0.352,764,0.964,"temozolomide, ifosfamide, dacarbazine, cyclophosphamide, melphalan, TH.302, carboplatin, carmustine, streptozotocin, mitomycin.c",0.453457336521869,0.0159229660971692,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.36606,-0.9,0.605,974,0.985,"melphalan, oxaliplatin, carboplatin, nimorazole, tirapazamine, valrubicin, carmustine, teroxirone",0.218244625347531,0.00656376950238827,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.38071,1.16,0.245,23,0.498,"SGI.1027",0.610833915635468,0.302770657240282,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",-0.30727,-0.757,0.774,1262,0.998,"idoxuridine, foscarnet",0.111259039317107,0.000869458712628891,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.54645,-1.35,0.149,1216,0.576,"CB.10.277, artesunate, floxuridine, mitomycin.c, cyclocytidine, anisomycin",0.826813731587726,0.239577516576788,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",-0.44472,-1.07,0.377,1145,0.938,"oxiperomide, amisulpride, piperacetazine, remoxipride, acetophenazine, mesoridazine, UH.232...., raclopride",0.423658649794207,0.0277971616209356,FALSE
+"A549","Pearson.est","estrogen receptor agonist",-0.33536,-0.825,0.714,1156,1,"estradiol, estrone",0.146301788223826,0,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.68394,2.06,0.0166,1,0.072,"toremifene",1.77989191195995,1.14266750356873,TRUE
+"A549","Pearson.est","FGFR inhibitor",-0.22677,-0.552,0.967,1381,0.972,"AZD4547",0.0145735259169983,0.0123337350737254,FALSE
+"A549","Pearson.est","FLT3 inhibitor",-0.36625,-0.891,0.618,769,0.955,"pacritinib, ENMD.2076, gilteritinib, TG.101348, tandutinib, KW.2449, GTP.14564, ponatinib, midostaurin, quizartinib",0.209011524911184,0.0199966284162537,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.55593,-1.37,0.134,1014,0.609,"methylprednisolone, dexamethasone.acetate, prednisolone, deflazacort, halcinonide, fludroxycortide, triamcinolone, flumethasone.pivalate, rimexolone, fluticasone.propionate, desonide, flumethasone, prednisolone.acetate, beclomethasone.dipropionate, ciclesonide, halobetasol.propionate, fluocinolone.acetonide",0.872895201635192,0.215382707367125,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.2729,0.834,0.649,161,0.775,"felbamate, CPP, CGP.37849",0.187755303199631,0.11069829749369,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.3269,-0.809,0.725,1318,0.999,"TWS.119, kenpaullone",0.139661993429006,0.000434511774017692,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",-0.63016,-1.54,0.0481,1371,0.708,"PHA.848125, AZD3463",1.31785492362617,0.149966742310231,FALSE
+"A549","Pearson.est","HCV inhibitor",-0.36842,-0.904,0.603,855,1,"narlaprevir, Ro.9187, mericitabine",0.219682687859849,0,FALSE
+"A549","Pearson.est","HDAC inhibitor",0.58289,1.79,0.024,248,0.119,"M.344, vorinostat, PCI.24781, tacedinaline, nexturastat.a, R306465, chidamide, NSC.3852, panobinostat, romidepsin, ACY.1215, trichostatin.a, pyroxamide, JNJ.26481585",1.61978875828839,0.924453038607469,TRUE
+"A549","Pearson.est","histamine receptor antagonist",-0.252,-0.606,0.93,979,1,"zolantidine, cimetidine, tiotidine, BF2.649, pheniramine, terfenadine, nizatidine",0.0315170514460649,0,FALSE
+"A549","Pearson.est","HMGCR inhibitor",0.33495,0.984,0.497,965,0.656,"pitavastatin, simvastatin, atorvastatin, mevastatin, lovastatin, fluvastatin",0.303643611266668,0.18309616062434,FALSE
+"A549","Pearson.est","HSP inhibitor",-0.33644,-0.82,0.707,1049,1,"BIIB021, NVP.AUY922, PU.H71, ganetespib, SNX.2112, tanespimycin",0.150580586203101,0,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.44934,-1.09,0.35,1102,0.953,"CEP.33779, AT.9283, AZ960, WHI.P154, TG.101209, filgotinib",0.455931955649724,0.0209070993616736,FALSE
+"A549","Pearson.est","KIT inhibitor",-0.30175,-0.732,0.823,1420,1,"KI.8751, dasatinib",0.0846001647877302,0,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.64964,-1.59,0.0238,1069,1,"serdemetan, nutlin.3, CGM097, idasanutlin, RITA",1.62342304294349,0,FALSE
+"A549","Pearson.est","MEK inhibitor",-0.40769,-1,0.461,854,0.939,"U.0126, PD.184352, trametinib, Ro.4987655, PD.198306, selumetinib, TAK.733, PD.0325901, refametinib, AZD8330, PD.318088, arctigenin, nobiletin",0.336299074610352,0.0273344077338891,FALSE
+"A549","Pearson.est","MET inhibitor",-0.3784,-0.926,0.574,804,1,"PHA.665752, NVP.BVU972, LY2801653, PF.04217903",0.241088107602027,0,FALSE
+"A549","Pearson.est","microtubule inhibitor",-0.41579,-1.01,0.449,810,0.942,"vinblastine, cabazitaxel, secnidazole, D.64131, cytochalasin.b, podophyllotoxin",0.347753658996677,0.0259490972071227,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.60826,-1.51,0.0639,958,0.681,"everolimus, OSI.027, deforolimus, PI.103, LY303511, PKI.179, palomid.529, voxtalisib, temsirolimus, WYE.125132, XL388, PP242, AZD2014, sirolimus, LY3023414, GSK2126458, NVP.BEZ235, GDC.0980, AZD8055, WAY.600, ku.0063794, MLN0128, SB.2343, WYE.354, torin.1",1.1944991418416,0.166852888087215,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",0.25891,0.766,0.781,304,0.749,"parthenolide...., Ro.106.9920, parthenolide, bortezomib, bindarit, curcumin, tyloxapol",0.1073489661227,0.125518182300534,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.49664,-1.2,0.251,830,0.864,"BW.180C, spiradoline, salvinorin.a, cebranopadol, trimebutine",0.600326278518962,0.0634862575211067,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",-0.23173,-0.57,0.953,598,0.978,"CMPD.1, SB.242235, TAK.715, VX.702, skepinone.l",0.0209070993616736,0.00966114521239857,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.41165,-1.03,0.443,1437,0.95,"E7449",0.35359627377693,0.0222763947111523,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37088,-0.91,0.597,1342,1,"CP.673451, KI.8751, crenolanib, dasatinib",0.224025668870631,0,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.25892,-0.637,0.898,1410,1,"mycophenolic.acid",0.0467236633326956,0,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",-0.33559,-0.817,0.715,1308,1,"zardaverine, YM.976",0.145693958198919,0,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.46642,-1.14,0.297,993,0.925,"PI.103, LY303511, YM.201636, BGT226, PKI.179, voxtalisib, PI3K.IN.2, TG.100713, LY3023414, GDC.0941, GSK2126458, ZSTK.474, NVP.BEZ235, GDC.0980, SB.2343",0.527243550682788,0.0338582672609674,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.46077,-1.14,0.309,763,0.925,"HMN.214, BI.2536, GSK461364, volasertib, rigosertib, GW.843682X",0.510041520575165,0.0338582672609674,FALSE
+"A549","Pearson.est","potassium channel blocker",-0.51452,-1.25,0.186,1203,0.795,"ibutilide, ML133",0.730487055782084,0.0996328713435297,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.5059,1.57,0.0432,719,0.187,"pterostilbene, clofibrate, GW.501516, ciprofibrate, fenofibrate, S26948, oleoylethanolamide",1.36451625318509,0.728158393463501,TRUE
+"A549","Pearson.est","progesterone receptor agonist",-0.41685,-1.02,0.445,1051,0.946,"dienogest, tanaproget, melengestrol.acetate",0.351639989019068,0.0241088635982073,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.51258,1.55,0.0783,231,0.152,"ONX.0914, carfilzomib, delanzomib, oprozomib, bortezomib",1.10623823794206,0.818156412055227,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.49133,-1.2,0.219,1210,0.864,"emetine, brefeldin.a, methacycline, cycloheximide, mercaptopurine, florfenicol",0.659555885159882,0.0634862575211067,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.3291,-0.813,0.708,1083,1,"NVP.TAE226, mubritinib, BMS.599626",0.149966742310231,0,FALSE
+"A549","Pearson.est","RAF inhibitor",0.39358,1.15,0.268,154,0.468,"vemurafenib, TAK.632, regorafenib, AZ.628",0.571865205971211,0.329754146925876,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",0.35506,1.05,0.376,936,0.584,"regorafenib, sorafenib, sunitinib, cabozantinib, apatinib, vandetanib",0.424812155072339,0.233587152887601,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.65541,1.94,0.024,318,0.0828,"fenretinide, adapalene, adarotene, tamibarotene, AM.580, CD.437",1.61978875828839,1.08196966321512,TRUE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.26455,-0.646,0.899,894,1,"cladribine, clofarabine, triapine, gemcitabine",0.0462403082667712,0,FALSE
+"A549","Pearson.est","serotonin receptor agonist",-0.5982,-1.48,0.0652,1362,0.682,"aripiprazole, ipsapirone",1.18575240426808,0.166215625343521,FALSE
+"A549","Pearson.est","serotonin receptor antagonist",-0.23574,-0.578,0.932,1296,0.989,"RS.16566, aripiprazole",0.0305840876460186,0.0048037084028206,FALSE
+"A549","Pearson.est","sodium channel blocker",-0.36995,-0.905,0.586,1323,1,"A.803467, ajmaline, butamben",0.232102383981909,0,FALSE
+"A549","Pearson.est","src inhibitor",-0.43544,-1.08,0.359,1397,0.945,"bosutinib, dasatinib",0.444905551421681,0.0245681914907371,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",-0.36538,-0.892,0.601,670,0.977,"terconazole, sulconazole, lanoconazole, ketoconazole",0.22112552799726,0.0101054362812269,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",0.29126,0.868,0.58,1028,0.824,"LY2109761, D.4476, SB.525334, SB.431542, repsox, adaprev",0.236572006437063,0.0840727883028842,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",-0.5782,-1.41,0.0883,1253,0.548,"ftorafur, raltitrexed, carmofur",1.05403929642243,0.261219441515631,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.44189,-1.11,0.347,1319,0.975,"exatecan.mesylate, teniposide, voreloxin, amsacrine, fleroxacin, idarubicin, TAS.103",0.459670525209126,0.0109953843014632,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",-0.42805,-1.05,0.396,810,0.961,"vinblastine, fenbendazole, dolastatin.10, plinabulin, albendazole, taltobulin, docetaxel, ABT.751, CYT.997, BNC105, parbendazole, epothilone.d, combretastatin.A.4, KX2.391, podophyllotoxin, verubulin, epothilone.b",0.402304814074488,0.0172766123314547,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",-0.26078,-0.626,0.902,833,1,"cabozantinib, hypericin, apatinib, vandetanib, UNC2250, NVP.TAE226, GTP.14564, aminopurvalanol.a, mubritinib, BMS.599626, dasatinib",0.0447934624580583,0,FALSE
+"A549","Pearson.est","VEGFR inhibitor",-0.24381,-0.595,0.933,603,1,"tivozanib, sunitinib, SAR131675, semaxanib, SU014813, AEE788, motesanib, foretinib, PD.173074, TG.100572, ENMD.2076, RAF265, cabozantinib, nintedanib, BMS.690514, cediranib, vandetanib, ZM.306416, vatalanib, XL.647, telatinib, lucitanib, MGCD.265, KI.8751",0.0301183562535,0,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",-0.32022,-0.782,0.742,840,1,"alfacalcidol, ercalcitriol, tacalcitol",0.129596094720973,0,FALSE
+"H1703","Pearson.est","EGFR inhibitor",0.82362,2.03,0,57,0.0668,"poziotinib, AZD8931, gefitinib, dacomitinib, XL.647, neratinib, afatinib, canertinib, lapatinib, erlotinib, osimertinib, BIBU.1361, AST.1306, pelitinib, BMS.690514, PD.153035, vandetanib, CUDC.101, tucatinib, icotinib, BMS.599626, ARRY.334543, PD.168393, WZ8040",Inf,1.17522353752445,TRUE
+"H1703","Pearson.est","Abl kinase inhibitor",0.46962,1.2,0.265,104,0.877,"dasatinib, ZM.306416, bosutinib",0.576754126063192,0.0570004066339595,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",-0.28411,-0.709,0.807,1007,0.904,"nefiracetam, xanomeline, oxiracetam",0.0931264652779296,0.0438315695246367,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.56334,-1.38,0.126,1032,0.534,"diphemanil, darifenacin, iododexetimide, methscopolamine",0.899629454882437,0.272458742971444,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",0.68445,1.73,0.0294,170,0.216,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",1.53165266958784,0.665546248849069,TRUE
+"H1703","Pearson.est","adrenergic receptor agonist",0.26044,0.654,0.893,150,0.977,"ritodrine, oxymetazoline, isoxsuprine",0.0491485411114536,0.0101054362812269,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",-0.30126,-0.735,0.782,1286,0.912,"metoprolol, carvedilol, pindolol",0.106793246940152,0.0400051616715838,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.4272,1.06,0.381,414,0.769,"uprosertib, triciribine, AZD5363, GDC.0068, CCT128930, MK.2206, GSK2110183, palomid.529",0.419075024324381,0.114073660198569,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.20058,0.526,0.968,523,1,"GW.788388, SB.505124, brigatinib, alectinib, AZD3463, CEP.37440, AP26113, NVP.TAE684",0.0141246426916063,0,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",-0.47712,-1.16,0.296,688,0.661,"cyproterone.acetate, bicalutamide, enzalutamide, RU.58841, nilutamide, flutamide",0.528708288941061,0.17979854051436,FALSE
+"H1703","Pearson.est","antioxidant",0.4485,1.12,0.306,44,0.921,"mesna",0.51427857351842,0.0357403698031511,FALSE
+"H1703","Pearson.est","AP inhibitor",-0.40077,-0.989,0.48,1417,0.77,"idronoxil",0.318758762624413,0.113509274827518,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.61923,-1.51,0.0802,984,0.498,"evodiamine, blebbistatin...., ouabain, omeprazole, k.strophanthidin, thonzonium, digitoxin, digitoxigenin, digoxin, oligomycin.a",1.09582563171584,0.302770657240282,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.63111,-1.57,0.0538,988,0.41,"hesperadin, TAK.901, alisertib, KW.2449, MK.5108, CCT137690, MK.8745, tozasertib, danusertib, barasertib.HQPA, AT.9283, aurora.a.inhibitor.i, ZM.447439, SNS.314, PF.03814735, AMG900, barasertib",1.26921772433361,0.387216143280265,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.21224,0.54,0.954,432,1,"tedizolid, azithromycin, azalomycin.b, tilmicosin",0.0204516252959049,0,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.31223,0.796,0.693,46,0.932,"finafloxacin",0.159266765388193,0.0305840876460186,FALSE
+"H1703","Pearson.est","BCL inhibitor",-0.32548,-0.794,0.711,776,0.916,"venetoclax, navitoclax, ABT.737, HA14.1, TW.37, oridonin",0.148130399270234,0.0381045263321496,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.40935,1.03,0.421,104,0.744,"dasatinib, bosutinib",0.375717904164332,0.128427064454121,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.17979,0.456,0.991,1190,0.99,"piperazine, CL.218872, lorazepam, zaleplon, ivermectin, eprinomectin, gamma.aminobutyric.acid, ZK.93423, CGS.20625, temazepam, bentazepam, nefiracetam, indiplon",0.00392634551472468,0.00436480540245009,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",0.39459,0.993,0.423,879,0.705,"JQ1...., OTX015, I.BET.762, I.BET151, bromosporine, PFI.1",0.373659632624958,0.151810883008601,FALSE
+"H1703","Pearson.est","calcium channel blocker",-0.32585,-0.795,0.738,1060,0.939,"penfluridol, pranidipine, SR.33805, carboxyamidotriazole",0.131943638176958,0.0273344077338891,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.3392,-0.827,0.648,1261,0.911,"MK.0812, UNBS.5162",0.188424994129407,0.0404816230270017,FALSE
+"H1703","Pearson.est","CDK inhibitor",0.19668,0.494,0.975,237,1,"indirubin, alvocidib, P276.00, TG.02, AZD5438",0.0109953843014632,0,FALSE
+"H1703","Pearson.est","CHK inhibitor",-0.34312,-0.832,0.652,1110,0.929,"SB.218078, PF.477736",0.18575240426808,0.0319842860063582,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",-0.39138,-0.977,0.459,1370,0.765,"tepoxalin, suxibuzone, AM.404, naproxen",0.338187314462739,0.116338564846382,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",-0.35725,-0.876,0.594,1104,0.9,"clotrimazole, metyrapone, cobicistat",0.226213555018806,0.0457574905606751,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.49277,-1.19,0.25,1080,0.666,"TH.302, mitomycin.c, carboplatin, satraplatin, cisplatin, dianhydrogalactitol, melphalan",0.602059991327962,0.176525770829699,FALSE
+"H1703","Pearson.est","DNA inhibitor",-0.4796,-1.14,0.32,1122,0.671,"tirapazamine, pibenzimol, carboplatin, valrubicin, melphalan, chlorambucil",0.494850021680094,0.173277479831008,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",0.46029,1.17,0.309,210,0.872,"azacitidine, decitabine, fdcyd",0.510041520575165,0.0594835150674328,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",-0.28929,-0.712,0.794,1123,0.921,"menadione, cephalomannine",0.100179497572904,0.0357403698031511,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.53567,-1.33,0.158,1157,0.518,"enocitabine, mitomycin.c, estramustine.phosphate, azodicarbonamide, cisplatin, artemisinin",0.801342913045577,0.285670240254767,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.42894,1.08,0.385,221,0.822,"domperidone, clebopride, lurasidone, acetophenazine, mesoridazine, oxiperomide",0.414539270491499,0.0851281824599496,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",0.35167,0.923,0.518,198,0.768,"erteberel, levonorgestrel, ethinyl.estradiol",0.285670240254767,0.114638779968488,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",0.43335,1.1,0.331,111,0.833,"clomifene, raloxifene",0.480172006224281,0.0793549985932124,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.58078,-1.4,0.121,1216,0.536,"regorafenib, lenvatinib, dovitinib, nintedanib, erdafitinib",0.91721462968355,0.27083521030723,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",-0.41291,-0.997,0.472,1036,0.812,"KW.2449, tyrphostin.AG.1296, tozasertib, quizartinib, sorafenib, TG.101348, midostaurin, dovitinib",0.326058001365912,0.0904439707588247,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",0.55382,1.41,0.0874,295,0.618,"hydrocortisone, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, flumethasone.pivalate, desonide, difluprednate, methylprednisolone, dexamethasone.acetate, fludroxycortide, prednisolone, flumethasone, halobetasol.propionate",1.0584885673656,0.209011524911184,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.39271,1.01,0.427,340,0.708,"diazooxonorleucine, SIB.1757, CGP.37849, IEM1754, kynurenic.acid, latrepirdine, CPP",0.369572124974976,0.149966742310231,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.33722,0.85,0.618,152,0.869,"indirubin, LY2090314",0.209011524911184,0.0609802235513335,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",0.30297,0.771,0.676,71,0.942,"GSK1904529A",0.170053304058364,0.0259490972071227,FALSE
+"H1703","Pearson.est","HCV inhibitor",-0.35152,-0.864,0.612,1038,0.896,"Ro.9187, mericitabine, narlaprevir",0.213248577854439,0.0476919903378748,FALSE
+"H1703","Pearson.est","HDAC inhibitor",-0.19195,-0.471,0.99,677,0.986,"trichostatin.a, AR.42, vorinostat, M.344, R306465, nexturastat.a, RGFP966, mocetinostat, dacinostat, NSC.3852, ACY.1215, SB.939, belinostat, pyroxamide, RG2833, entinostat, resminostat, scriptaid, chidamide",0.00436480540245009,0.0061230850587888,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.29217,0.733,0.753,181,0.936,"ranitidine, terfenadine, levocetirizine, astemizole",0.123205023799299,0.0287241512618947,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.94383,-2.26,0,1408,0,"fluvastatin, mevastatin, atorvastatin, pitavastatin",Inf,Inf,TRUE
+"H1703","Pearson.est","HSP inhibitor",-0.52095,-1.28,0.211,1069,0.584,"PU.H71, SNX.2112, NVP.AUY922, ganetespib, NMS.E973",0.675717544702307,0.233587152887601,FALSE
+"H1703","Pearson.est","JAK inhibitor",-0.27921,-0.678,0.842,1154,0.921,"tozasertib, ruxolitinib, AT.9283, TG.101348, PRT062070",0.0746879085003505,0.0357403698031511,FALSE
+"H1703","Pearson.est","KIT inhibitor",-0.50547,-1.24,0.232,1180,0.598,"telatinib, cediranib, regorafenib, sorafenib, midostaurin, motesanib, lenvatinib, pazopanib",0.6345120151091,0.223298816011589,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.37108,-0.901,0.586,1121,0.882,"AMG.232, serdemetan",0.232102383981909,0.0545314148681803,FALSE
+"H1703","Pearson.est","MEK inhibitor",0.84685,2.18,0,107,0.0169,"trametinib, AS.703026, cobimetinib, AZD8330, TAK.733, PD.0325901, selumetinib, Ro.4987655, MEK162, PD.318088, refametinib, PD.198306, PD.184352",Inf,1.77211329538633,TRUE
+"H1703","Pearson.est","MET inhibitor",-0.40727,-1,0.442,1126,0.836,"LY2801653, AMG458",0.354577730650908,0.0777937225609836,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.61266,-1.49,0.0643,881,0.429,"triclabendazole, colchicine, D.64131, cytochalasin.b, podophyllotoxin, estramustine.phosphate, cabazitaxel, secnidazole, vinflunine, vinblastine",1.19178902707578,0.367542707815276,FALSE
+"H1703","Pearson.est","mTOR inhibitor",0.26649,0.663,0.832,378,0.999,"GSK2126458, LY303511, PP242, WAY.600, XL388, WYE.354, OSI.027, PF.04691502, GDC.0980, voxtalisib, WYE.125132",0.0798766737092761,0.000434511774017692,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.19837,-0.48,0.981,1325,1,"BAY.11.7082",0.0083309926200515,0,FALSE
+"H1703","Pearson.est","opioid receptor agonist",-0.22538,-0.54,0.957,325,1,"ADL5859, trimebutine, BW.180C, cebranopadol, salvinorin.a, spiradoline",0.0190880622231565,0,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.54823,1.39,0.135,658,0.584,"SB.239063, TAK.715, talmapimod, SB.242235, skepinone.l, CMPD.1, VX.702",0.869666231504994,0.233587152887601,FALSE
+"H1703","Pearson.est","PARP inhibitor",-0.59277,-1.45,0.0952,1307,0.471,"olaparib, AZD2461, talazoparib",1.02136305161553,0.326979092871104,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.55008,-1.35,0.161,1171,0.515,"crenolanib, telatinib, trapidil, regorafenib, CP.673451, linifanib, sorafenib, motesanib, lenvatinib, dovitinib, axitinib, nintedanib, pazopanib",0.79317412396815,0.288192770958809,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.42808,-1.05,0.407,1062,0.765,"AS.1949490, menadione, BVT.948, GSK2830371, bis.maltolato.oxovanadium.IV.",0.39040559077478,0.116338564846382,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",-0.40968,-0.996,0.476,1176,0.785,"zardaverine, YM.976, enoximone, GSK256066",0.322393047279507,0.105130343254747,FALSE
+"H1703","Pearson.est","PI3K inhibitor",0.4203,1.05,0.398,351,0.746,"alpelisib, taselisib, GSK2126458, TG.100713, CH5132799, LY303511, GDC.0941, PIK.75, PF.04691502, PI.828, GDC.0980, AZD6482, voxtalisib",0.400116927926312,0.127261172527331,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.64391,-1.59,0.0495,1127,0.726,"GSK461364, HMN.214, BI.2536, rigosertib, volasertib",1.30539480106643,0.139063379299906,FALSE
+"H1703","Pearson.est","potassium channel blocker",-0.5592,-1.36,0.151,1416,0.534,"dofetilide",0.821023052706831,0.272458742971444,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",-0.44832,-1.12,0.342,1054,0.655,"pterostilbene, clofibrate, GW.501516",0.465973893943865,0.183758700008217,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.31414,-0.767,0.75,982,0.911,"danazol, dienogest, tanaproget, norgestrel, norethindrone",0.1249387366083,0.0404816230270017,FALSE
+"H1703","Pearson.est","proteasome inhibitor",-0.45691,-1.12,0.324,926,0.655,"ixazomib, oprozomib, delanzomib, ONX.0914, MG.132",0.489454989793388,0.183758700008217,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.51746,-1.27,0.21,1161,0.569,"thiostrepton, clofoctol, puromycin, bruceantin, mercaptopurine, homoharringtonine, harringtonine, anguidine",0.677780705266081,0.244887733604929,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.54835,1.43,0.105,200,0.664,"BMS.599626, AV.412, NVP.TAE226, CP.724714",0.978810700930062,0.177831920631982,FALSE
+"H1703","Pearson.est","RAF inhibitor",0.30081,0.767,0.733,156,0.914,"AZ.628, CEP.32496, SB.590885",0.134896025358872,0.0390538042661686,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.44018,1.11,0.323,29,0.873,"vandetanib",0.490797477668897,0.0589857562944303,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",0.40017,1.01,0.441,48,0.708,"CD.437, tamibarotene",0.355561410532161,0.149966742310231,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.63686,-1.57,0.0595,963,0.41,"hydroxyurea, fludarabine.phosphate, triapine, gemcitabine, fludarabine, cladribine, clofarabine, pentostatin",1.22548303427145,0.387216143280265,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",-0.62589,-1.57,0.0587,1151,0.41,"SR.57227A, pardoprunox, aripiprazole",1.23136189875239,0.387216143280265,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",-0.47896,-1.17,0.268,1262,0.674,"paliperidone, lerisetron, aripiprazole",0.571865205971211,0.17134010346468,FALSE
+"H1703","Pearson.est","sodium channel blocker",-0.25562,-0.619,0.909,1021,0.963,"brivaracetam, triamterene, oxcarbazepine, butamben, cibenzoline",0.0414361167780325,0.0163737128754655,FALSE
+"H1703","Pearson.est","src inhibitor",0.66148,1.76,0.0208,104,0.224,"saracatinib, dasatinib, ZM.306416, bosutinib",1.68193666503724,0.649751981665837,TRUE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.31245,-0.772,0.73,1392,0.927,"chlormidazole",0.136677139879544,0.0329202658555029,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.38532,0.99,0.458,480,0.679,"repsox, D.4476, SB.431542, LY2109761",0.339134521996131,0.168130225719498,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",0.46965,1.2,0.249,364,0.877,"carmofur, capecitabine, raltitrexed",0.603800652904264,0.0570004066339595,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.73872,-1.81,0.0152,1243,0.23,"irinotecan, dexrazoxane, rubitecan, voreloxin, doxorubicin, valrubicin, mitoxantrone, TAS.103, amonafide, nemorubicin, daunorubicin, teniposide, etoposide, topotecan, etoposide.phosphate, epirubicin",1.81815641205523,0.638272163982407,TRUE
+"H1703","Pearson.est","tubulin polymerization inhibitor",-0.60989,-1.5,0.0875,973,0.458,"fosbretabulin, epothilone.b, podophyllotoxin, mebendazole, fenbendazole, flubendazole, plinabulin, vinorelbine, docetaxel, epothilone.d, ABT.751, dolastatin.10, paclitaxel, CYT.997, vincristine, combretastatin.A.4, vindesine, KX2.391, vinblastine, verubulin, taltobulin, BNC105",1.05799194697769,0.339134521996131,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.41593,1.06,0.374,200,0.769,"vandetanib, dasatinib, BMS.599626, AV.412, NVP.TAE226, hypericin, GTP.14564, CP.724714",0.42712839779952,0.114073660198569,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",-0.30703,-0.751,0.753,1180,0.912,"telatinib, cediranib, regorafenib, SAR131675, RAF265, linifanib, sorafenib, motesanib, lenvatinib, dovitinib, axitinib, tivozanib, nintedanib, pazopanib",0.123205023799299,0.0400051616715838,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.70695,1.79,0.0187,321,0.254,"tacalcitol, paricalcitol, calcitriol, maxacalcitol, ercalcitriol, alfacalcidol",1.7281583934635,0.595166283380062,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",0.7297,1.75,0.00865,80,0.649,"gefitinib, poziotinib, afatinib, pelitinib, XL.647, CUDC.101, AZD8931, erlotinib, dacomitinib, BIBU.1361, AST.1306, osimertinib, lapatinib, neratinib, vandetanib, canertinib, icotinib, PD.153035, WZ.4002, tucatinib",2.06298389253519,0.187755303199631,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",0.56625,1.35,0.148,484,0.67,"dasatinib, ZM.306416, tozasertib, GZD824, nilotinib, ponatinib, imatinib, bosutinib",0.829738284605043,0.173925197299174,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",-0.3505,-0.923,0.483,1398,0.728,"nefiracetam",0.316052869248488,0.137868620686963,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.27741,-0.739,0.748,1143,0.878,"darifenacin, diphemanil, methscopolamine",0.126098402135539,0.0565054840938974,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",0.48282,1.19,0.243,301,0.717,"istradefylline, sulmazole, CGS.15943, PSB.1115",0.614393726401688,0.1444808443322,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",0.30493,0.732,0.778,334,0.955,"ritodrine, terbutaline, oxymetazoline, methyldopa, isoxsuprine",0.109020403010311,0.0199966284162537,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",-0.3474,-0.935,0.538,1306,0.74,"levobunolol, metoprolol, propranolol, pindolol",0.269217724333611,0.130768280269024,FALSE
+"HCC15","Pearson.est","AKT inhibitor",0.38654,0.927,0.548,384,0.793,"uprosertib, MK.2206, GSK2110183, triciribine, AT7867",0.261219441515631,0.100726812682396,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.49057,1.17,0.273,400,0.697,"lorlatinib, SB.505124, CEP.37440, alectinib, AZD3463",0.563837352959244,0.156767221901991,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.82341,-2.22,0.00342,1256,0.0411,"flutamide, RU.58841, enzalutamide, cyproterone.acetate",2.46597389394387,1.38615817812393,TRUE
+"HCC15","Pearson.est","antioxidant",-0.45702,-1.2,0.266,1426,0.628,"taurine, rutin",0.575118363368933,0.202040356262804,FALSE
+"HCC15","Pearson.est","AP inhibitor",-0.43189,-1.16,0.257,1212,0.653,"birinapant, LCL.161, GDC.0152",0.590066876668705,0.185086818724926,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",-0.48383,-1.3,0.193,1266,0.707,"omeprazole, digitoxin, rabeprazole, digitoxigenin, oligomycin.a",0.714442690992226,0.150580586203101,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",0.12973,0.308,0.999,320,1,"GSK1070916, tozasertib, ENMD.2076",0.000434511774017692,0,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.26389,-0.709,0.792,380,0.858,"tedizolid, valnemulin, azithromycin, tilmicosin, azalomycin.b, dirithromycin, radezolid, josamycin",0.101274818410506,0.0665127121512946,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.21394,0.514,0.978,380,0.989,"finafloxacin, novobiocin, sarafloxacin",0.00966114521239857,0.0048037084028206,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.34132,0.809,0.67,346,0.886,"obatoclax, gossypol, venetoclax",0.173925197299174,0.0525662781129492,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.57356,1.38,0.122,484,0.921,"dasatinib, tozasertib, GZD824, nilotinib, ponatinib, imatinib, bosutinib",0.913640169325252,0.0357403698031511,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.26517,0.64,0.891,543,0.961,"ZK.93423, piperazine, bentazepam, zaleplon, CL.218872, eprinomectin",0.0501222959631252,0.0172766123314547,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.46165,1.14,0.31,491,0.701,"JQ1...., I.BET.762, OTX015, I.BET151",0.508638306165727,0.154281982033341,FALSE
+"HCC15","Pearson.est","calcium channel blocker",0.41373,0.993,0.461,560,0.737,"tetrandrine, SKF.96365, efonidipine.monoethanolate, penfluridol, mibefradil, fendiline",0.336299074610352,0.132532512140949,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.55356,1.35,0.155,173,0.67,"ZK811752, PF.04136309",0.809668301829709,0.173925197299174,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.49761,1.18,0.295,385,0.706,"indisulam, P276.00, alvocidib, AT.7519, TG.02, dinaciclib, AZD5438, ribociclib, PHA.848125, palbociclib, JNJ.7706621",0.530177984021837,0.151195298948196,FALSE
+"HCC15","Pearson.est","CHK inhibitor",-0.32408,-0.875,0.615,467,0.747,"LY2603618, AZD7762, LY2606368, PF.477736, SCH.900776, CHIR.124, SB.218078",0.211124884224583,0.126679398184601,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.4483,-1.24,0.2,1347,0.611,"AM.404, sulfasalazine, metoxibutropate, suxibuzone, naproxen",0.698970004336019,0.213958789757446,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",0.49946,1.2,0.252,165,0.731,"morin, metyrapone",0.598599459218456,0.13608262304214,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",-0.38211,-1.04,0.329,1151,0.623,"streptozotocin, ifosfamide, melphalan, satraplatin, cisplatin, dianhydrogalactitol, mitomycin.c",0.482804102050026,0.20551195334083,FALSE
+"HCC15","Pearson.est","DNA inhibitor",0.22993,0.549,0.945,229,0.992,"sangivamycin, carmustine, bendamustine",0.0245681914907371,0.00348832784582135,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.39417,0.945,0.502,225,0.782,"decitabine, azacitidine",0.299296282854981,0.106793246940152,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.40542,0.994,0.467,193,0.758,"cidofovir, idoxuridine",0.330683119433888,0.120330794367946,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",-0.60115,-1.68,0.0639,1322,0.286,"floxuridine, cisplatin, artemisinin, estramustine.phosphate, mitomycin.c",1.1944991418416,0.543633966870957,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",0.45684,1.08,0.391,250,0.687,"clebopride, lurasidone, domperidone, mesoridazine, sertindole, amisulpride, thioproperazine",0.407823242604133,0.16304326294045,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.29437,-0.81,0.645,1442,0.828,"estradiol.cypionate",0.190440285364732,0.0819696632151199,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",0.63709,1.55,0.0579,134,0.529,"raloxifene, clomifene",1.23732143627256,0.276544327964814,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.40749,0.998,0.457,318,0.774,"PD.173074, MK.2461, lucitanib, regorafenib",0.34008379993015,0.111259039317107,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.4217,1.03,0.417,430,0.736,"gilteritinib, pacritinib, tozasertib, TG.02, sunitinib, ENMD.2076, sorafenib, ponatinib, tyrphostin.AG.1296",0.379863945026242,0.133122185662501,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",0.52471,1.25,0.208,327,0.687,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate, flumethasone.pivalate, halcinonide, halobetasol.propionate, fluocinolone.acetonide, prednisolone.acetate, desonide, prednisolone",0.681936665037238,0.16304326294045,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",0.28399,0.693,0.832,354,0.965,"SIB.1757, CPP, diazooxonorleucine, CGP.37849",0.0798766737092761,0.0154726866562074,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.18838,-0.512,0.971,1218,0.978,"indirubin, CHIR.98014",0.0127807700919951,0.00966114521239857,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",0.46534,1.13,0.317,501,0.664,"GSK1904529A, GSK1838705A, PHA.848125, AZD3463, lestaurtinib, danusertib",0.498940737782249,0.177831920631982,FALSE
+"HCC15","Pearson.est","HCV inhibitor",0.34683,0.83,0.679,47,0.897,"embelin",0.168130225719498,0.0472075569559079,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.51246,1.26,0.221,360,0.706,"PCI.24781, R306465, M.344, romidepsin, JNJ.26481585, dacinostat, givinostat, belinostat, trichostatin.a, NSC.3852, vorinostat, panobinostat, tacedinaline, entinostat, nexturastat.a",0.655607726314889,0.151195298948196,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",0.34689,0.828,0.671,479,0.877,"ranitidine, astemizole, pheniramine, ebastine, chloropyramine, tecastemizole, lafutidine",0.173277479831008,0.0570004066339595,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",0.48141,1.16,0.295,470,0.688,"lovastatin, pitavastatin, simvastatin",0.530177984021837,0.162411561764489,FALSE
+"HCC15","Pearson.est","HSP inhibitor",-0.4397,-1.14,0.286,1253,0.642,"XL888, KW.2478, alvespimycin, VER.49009, tanespimycin",0.543633966870957,0.192464971931147,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.37889,0.91,0.574,389,0.803,"atiprimod, pacritinib, tozasertib, TG.02, filgotinib, AZD1480",0.241088107602027,0.095284454721319,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.27329,0.658,0.885,483,0.962,"dasatinib, sunitinib, regorafenib, sorafenib, imatinib, vatalanib",0.0530567293021746,0.0168249279621871,FALSE
+"HCC15","Pearson.est","MDM inhibitor",0.43923,1.09,0.364,154,0.692,"nutlin.3, idasanutlin",0.438898616350944,0.159893905543242,FALSE
+"HCC15","Pearson.est","MEK inhibitor",0.69964,1.72,0.0189,156,0.421,"cobimetinib, AZD8330, MEK162, TAK.733, AS.703026, trametinib, PD.0325901, Ro.4987655, selumetinib, MEK1.2.inhibitor",1.72353819582676,0.375717904164332,FALSE
+"HCC15","Pearson.est","MET inhibitor",-0.62128,-1.69,0.0635,1099,0.34,"INC.280, AMG458, NVP.BVU972",1.19722627470802,0.468521082957745,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",-0.35202,-0.961,0.494,1358,0.729,"cytochalasin.b, estramustine.phosphate",0.306273051076353,0.137272471682025,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",0.2973,0.715,0.79,145,0.957,"GSK2126458, WAY.600, LY303511, XL388, OSI.027",0.102372908709559,0.0190880622231565,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.52477,1.26,0.209,266,0.706,"curcumin, parthenolide...., bortezomib, Ro.106.9920, parthenolide",0.679853713888946,0.151195298948196,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",-0.40083,-1.06,0.395,578,0.626,"trimebutine, salvinorin.a, cebranopadol, ADL5859, BW.180C, spiradoline",0.40340290437354,0.20342566678957,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",0.56299,1.34,0.153,583,0.642,"SB.242235, SB.239063, TAK.715, CMPD.1, talmapimod, VX.702",0.815308569182401,0.192464971931147,FALSE
+"HCC15","Pearson.est","PARP inhibitor",-0.41383,-1.11,0.295,1235,0.612,"olaparib, AZD2461, E7449",0.530177984021837,0.213248577854439,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.19253,-0.522,0.959,1173,1,"crenolanib, lenvatinib, motesanib, tandutinib, trapidil, nintedanib, linifanib",0.0181813928293364,0,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.50615,1.21,0.232,361,0.749,"GSK2830371, alexidine, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate",0.6345120151091,0.125518182300534,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.39081,-1.07,0.361,1157,0.644,"zardaverine, papaverine, GSK256066, YM.976, enoximone",0.442492798094342,0.191114132640188,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",0.35581,0.853,0.657,503,0.879,"buparlisib, YM.201636, GSK2126458, LY303511, TG.100713, taselisib, GDC.0941, PIK.75, AZD6482, CUDC.907, PF.04691502, pilaralisib, PF.05212384",0.182434630440219,0.0560111249262281,FALSE
+"HCC15","Pearson.est","PLK inhibitor",-0.48448,-1.32,0.185,1111,0.757,"GSK461364, HMN.214, GW.843682X, BI.2536, volasertib",0.732828271596986,0.120904120499927,FALSE
+"HCC15","Pearson.est","potassium channel blocker",-0.47471,-1.27,0.184,1267,0.616,"dofetilide, ML133",0.735182176990464,0.210419287835575,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.47031,-1.28,0.186,1108,0.662,"clofibrate, pterostilbene, ciprofibrate, GW.501516",0.730487055782084,0.1791420105603,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.50578,-1.35,0.136,1402,0.804,"dienogest, norgestrel",0.866461091629782,0.0947439512515487,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.4017,0.992,0.462,195,0.717,"carfilzomib, bortezomib",0.335358024443874,0.1444808443322,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.46752,1.11,0.346,417,0.679,"brefeldin.a, clindamycin.phosphate, chloramphenicol.palmitate, homoharringtonine, azomycin..2.nitroimidazole., cycloheximide, bruceantin, tedizolid.phosphate",0.460923901207223,0.168130225719498,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.46669,1.13,0.294,377,0.664,"AV.412, NVP.TAE226, PP.121",0.531652669587843,0.177831920631982,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.63823,1.51,0.0622,200,0.557,"AZ.628, dabrafenib, vemurafenib, CEP.32496, LGX818, SB.590885",1.20620961530918,0.254144804826271,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.57362,1.37,0.125,406,0.751,"vandetanib, sunitinib, regorafenib, sorafenib",0.903089986991944,0.124360062995832,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",0.71117,1.7,0.0219,194,0.322,"tamibarotene, CD.437, adarotene, AM.580",1.65955588515988,0.492144128304169,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.40211,-1.11,0.309,1086,0.612,"pentostatin, fludarabine, cytarabine, hydroxyurea, clofarabine, gemcitabine",0.510041520575165,0.213248577854439,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",-0.66371,-1.84,0.0226,1447,0.323,"aripiprazole",1.6458915608526,0.490797477668897,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",-0.31928,-0.892,0.58,1447,0.748,"aripiprazole",0.236572006437063,0.126098402135539,FALSE
+"HCC15","Pearson.est","sodium channel blocker",-0.26782,-0.709,0.771,1276,0.858,"cibenzoline, lappaconite, oxcarbazepine",0.112945621949043,0.0665127121512946,FALSE
+"HCC15","Pearson.est","src inhibitor",0.64064,1.56,0.0495,105,0.627,"saracatinib, dasatinib, ZM.306416, PP.2",1.30539480106643,0.202732459169284,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",0.27717,0.669,0.855,465,0.972,"terconazole, sulconazole, lanoconazole",0.0680338852718274,0.0123337350737254,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.57039,1.37,0.15,66,0.751,"repsox, D.4476",0.823908740944319,0.124360062995832,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.53782,1.3,0.177,44,0.697,"carmofur",0.752026733638193,0.156767221901991,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",-0.63409,-1.75,0.0422,1117,0.341,"daunorubicin, epirubicin, camptothecin, rubitecan, valrubicin, amsacrine, teniposide, exatecan.mesylate, etoposide, idarubicin, nemorubicin, genz.644282, voreloxin, TAS.103, amonafide, mitoxantrone",1.37468754903833,0.467245621007502,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.23288,0.556,0.952,541,1,"nocodazole, indibulin, vindesine, vinorelbine, oxibendazole, podophyllotoxin, plinabulin, albendazole, mebendazole, vincristine, verubulin, parbendazole",0.0213630516155257,0,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.42549,1.03,0.423,406,0.736,"vandetanib, dasatinib, tivantinib, AV.412, NVP.TAE226, sunitinib, regorafenib, PP.121, sorafenib",0.373659632624958,0.133122185662501,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.33429,0.801,0.715,320,0.877,"XL.647, vandetanib, ZM.306416, PD.173074, BMS.690514, MK.2461, lucitanib, sunitinib, regorafenib, ENMD.2076",0.145693958198919,0.0570004066339595,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",-0.27967,-0.753,0.734,403,0.89,"alfacalcidol, calcitriol, tacalcitol, ercalcitriol, paricalcitol, maxacalcitol, doxercalciferol",0.134303940083929,0.0506099933550872,FALSE
diff --git a/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren/Coldren/DMEA/DMEA_venn_diagram.pdf
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diff --git a/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_interactive_network.graph.html b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
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--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-f6c0c0ae815eafe5f508" style="width:960px;height:500px;"></div>
+</div>
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diff --git a/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_mean_results.csv
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@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"estrogen receptor antagonist",1.00241666666667,0.696588891192885,0.124327712710528,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.265331768848105
+"RAF inhibitor",0.698,1.13162080060577,0.0047006947780887,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0278684047558116
+"MEK inhibitor",0.667833333333333,1.60164357817685,5.08540197049992e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"H1650, H520, H460, H1299, H1703",0.000844176727102987
+"retinoid receptor agonist",0.610333333333333,1.03738520357968,0.171997633009449,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.339900084280579
+"HMGCR inhibitor",0.5195,1.9209607681385,8.5331314142516e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"HCC95, H1975, H1648, H2126, H1299, HCC44, H1703",0.000395749475218249
+"MDM inhibitor",0.45425,1.52040958147946,0.00416580339781743,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,4,"H1650, HCC95, H1648, H460",0.0265970524629882
+"glutamate receptor antagonist",0.43275,0.716226237111761,0.987358742586612,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"BCL inhibitor",0.425416666666667,1.05488159252232,0.304199929869937,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.515277432228669
+"dopamine receptor antagonist",0.4205,0.89417046371585,0.875993102824703,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"RET tyrosine kinase inhibitor",0.406416666666667,1.0790967989551,0.291163973828253,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50697819475302
+"phosphatase inhibitor",0.393166666666667,0.983230744520175,0.513890846378439,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.804772457536046
+"thymidylate synthase inhibitor",0.353416666666667,1.40048059662216,4.67424917816275e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H2126, HCC44",0.000844176727102987
+"FGFR inhibitor",0.32725,1.13192427669956,0.176518018039236,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.340720825517595
+"benzodiazepine receptor agonist",0.32275,0.573400562037965,0.999999744255947,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"Bcr.Abl kinase inhibitor",0.311416666666667,1.25046772764386,0.0259847661335041,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.0937711125687321
+"antioxidant",0.2925,1.39479633573573,0.0129712791125946,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.0616112951911576
+"Abl kinase inhibitor",0.2875,1.24619431579801,0.041043726324705,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.121665331605376
+"acetylcholine receptor agonist",0.236583333333333,0.981314559736844,0.770707396593526,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"cytochrome P450 inhibitor",0.232083333333333,1.30142770960716,0.0150124187360823,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.0655805660576229
+"proteasome inhibitor",0.221916666666667,1.25182531879966,0.0251527702555807,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0937711125687321
+"CC chemokine receptor antagonist",0.215916666666667,1.30495743283647,0.00678708773166565,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0375552187818833
+"p38 MAPK inhibitor",0.213916666666667,1.20391123640886,0.094665808369185,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.218257280406732
+"adenosine receptor antagonist",0.185,1.38904735176831,0.00218259813041714,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H2126, H1299, H1703",0.0164686949840566
+"TGF beta receptor inhibitor",0.164,1.2726662063272,0.0381301100288775,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.117214782681364
+"adrenergic receptor agonist",0.142583333333333,0.841425031320874,0.992401426537453,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"FLT3 inhibitor",0.13425,1.09332463157106,0.410067230754878,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.667364316718723
+"bacterial DNA gyrase inhibitor",0.13425,1.03675017811341,0.684040247241143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.946255675350247
+"HCV inhibitor",0.126916666666667,1.05333370852506,0.633163264300218,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"sterol demethylase inhibitor",0.125583333333333,0.99504037911062,0.792730624396318,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"histamine receptor antagonist",0.113166666666667,0.67722251390022,0.999997961805646,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"growth factor receptor inhibitor",0.10475,1.26224044136535,0.0379479136146386,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.117214782681364
+"ALK tyrosine kinase receptor inhibitor",0.0668333333333333,1.01703542740952,0.741185677459224,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.999999744255948
+"EGFR inhibitor",0.058,1.84339055201895,3.20369112697271e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,7,"HCC95, H1975, H1648, H2126, H520, H1299, H1703",0.000844176727102987
+"mTOR inhibitor",0.0465833333333333,1.05096738625406,0.614580823363627,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"glycogen synthase kinase inhibitor",0.0435,0.980106534098114,0.998823553215968,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.999999744255948
+"bromodomain inhibitor",0.04025,1.53547914493993,0.0340763504946138,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, A549",0.113133483642118
+"glucocorticoid receptor agonist",0.0339166666666667,1.29597309584401,0.0158476448165722,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0657677259887745
+"src inhibitor",0.0273333333333334,1.50636403503954,8.24951913546827e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"HCC95, H520, H1299, HCC44, H1703",0.00114118348040644
+"KIT inhibitor",0.0248333333333333,0.94747125965846,0.935832669479616,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"HDAC inhibitor",0.0211666666666666,1.1537745039914,0.293192209013795,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H2126, A549",0.50697819475302
+"acetylcholine receptor antagonist",-0.00183333333333337,1.23950597441322,0.0779561053013444,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.200456681429326
+"estrogen receptor agonist",-0.00725000000000005,0.801671336532735,0.999452080686153,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"DNA inhibitor",-0.00916666666666668,0.931550694793202,0.966638581217711,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"progesterone receptor agonist",-0.0171666666666666,1.09721745862666,0.46373187184175,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.740187410824331
+"PI3K inhibitor",-0.0253333333333333,1.06693608339985,0.608568603424358,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"tyrosine kinase inhibitor",-0.02975,1.00830380748156,0.811127303266585,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"DNA polymerase inhibitor",-0.0300833333333334,1.04827507305472,0.588924130380289,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"DNA methyltransferase inhibitor",-0.0356666666666666,1.13077329400028,0.283229556884785,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.50697819475302
+"ribonucleotide reductase inhibitor",-0.0415000000000001,1.28968385837206,0.0329390189674143,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.113133483642118
+"opioid receptor agonist",-0.0475833333333333,1.23267303475255,0.0933508384303763,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.218257280406732
+"AP inhibitor",-0.0699166666666666,1.33192556837722,0.101268730435768,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1975, A549",0.227170395301859
+"PPAR receptor agonist",-0.0780833333333334,1.27135793245814,0.0627046999800293,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.167886777365885
+"NFkB pathway inhibitor",-0.0893333333333333,0.704062669386925,0.99998542119808,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"JAK inhibitor",-0.0970833333333334,1.01858515583969,0.812129700429645,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"AKT inhibitor",-0.119916666666667,1.24744243505978,0.0796996444237081,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.200456681429326
+"phosphodiesterase inhibitor",-0.125833333333333,0.938912313974704,0.926782184949637,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"PDGFR tyrosine kinase receptor inhibitor",-0.1285,1.00276857658276,0.762426676890818,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"protein tyrosine kinase inhibitor",-0.166416666666667,1.3955663860522,0.000996752902459099,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H1648, H2126",0.0103413113630132
+"CDK inhibitor",-0.201916666666667,1.16107743523249,0.0941930017532901,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.218257280406732
+"CHK inhibitor",-0.209583333333333,1.18310919025279,0.204180911811555,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.385159447280888
+"protein synthesis inhibitor",-0.248833333333333,1.17580137726909,0.140001294478339,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.290502686042554
+"serotonin receptor antagonist",-0.263916666666667,1.03078244405388,0.624882064154891,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"VEGFR inhibitor",-0.2715,0.741741868846568,0.999534634664959,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"calcium channel blocker",-0.27525,0.937528775315966,0.866095767459057,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"adrenergic receptor antagonist",-0.275916666666667,0.770525494632584,0.998631425519013,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"androgen receptor antagonist",-0.29825,1.28566609018615,0.0133614857041065,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, A549, HCC15",0.0616112951911576
+"bacterial 50S ribosomal subunit inhibitor",-0.31975,0.987198158702423,0.630216737456706,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.890721202320646
+"Aurora kinase inhibitor",-0.37975,1.24472122654761,0.0085197872386698,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0441963963005996
+"PARP inhibitor",-0.394416666666667,1.1955539954601,0.044614158385556,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.127688798137971
+"DNA alkylating agent",-0.401166666666667,0.901674486046865,0.846215198379105,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"potassium channel blocker",-0.408,1.0340825534128,0.399605399146996,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.663344962584014
+"sodium channel blocker",-0.409833333333333,0.682226013380708,0.998626395757675,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"DNA synthesis inhibitor",-0.438166666666667,1.10393995499865,0.226980227883247,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.41865242031799
+"vitamin D receptor agonist",-0.442416666666667,1.55978701683236,0.0206707016748029,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1648, H2126, H1299",0.08169848757184
+"MET inhibitor",-0.4645,1.14146233960095,0.165128270570095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.334284059934583
+"cyclooxygenase inhibitor",-0.46875,0.609628370402822,0.999158830773346,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.999999744255948
+"tubulin polymerization inhibitor",-0.49775,1.28656894844035,0.00133279142519831,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H2126, H1299",0.012291298699051
+"PLK inhibitor",-0.596666666666667,1.47931392779548,9.53613193296986e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H460, H1299",0.000395749475218249
+"microtubule inhibitor",-0.613833333333333,1.17771124978867,0.00249951164829279,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H2126, H460, H1299",0.0172882889006918
+"topoisomerase inhibitor",-0.66875,1.22133058029497,0.00183574463749805,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1299, H1703",0.0152366804912338
+"ATPase inhibitor",-0.752666666666667,1.00384717537838,0.0468005257141872,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.129481454475918
+"serotonin receptor agonist",-0.81,1.27959148310559,0.00014168317666895,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1975",0.00167995766621755
+"HSP inhibitor",-0.958416666666667,0.69444293676604,0.124673963675616,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.265331768848105
diff --git a/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..6cd3803
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_results.csv
@@ -0,0 +1,997 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H1650","Pearson.est","EGFR inhibitor",-0.18808,-0.582,0.967,1165,0.95,"AZD8931, TAK.285, FERb.033, WZ8040, icotinib, WZ.3146, BMS.599626, neratinib, rociletinib, ARRY.334543, CP.724714, lapatinib, osimertinib, PD.168393, GW.583340, brigatinib, canertinib, BMS.690514, tucatinib",0.0145735259169983,0.0222763947111523,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",0.54126,1.27,0.168,427,0.685,"KW.2449, GZD824, tozasertib, bafetinib, ponatinib, nilotinib, flumatinib",0.774690718274137,0.164309428507574,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.55053,1.31,0.143,550,0.745,"oxiracetam, tremorine, pilocarpine, xanomeline, nicotine",0.844663962534938,0.127843727251707,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.52982,-1.61,0.0464,764,0.393,"hyoscyamine, iododexetimide, dicycloverine, diphemanil, methscopolamine, darifenacin",1.33348201944512,0.405607449624573,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",0.45164,1.08,0.365,328,0.885,"istradefylline, sulmazole, PSB.1115, SCH.58261",0.437707135543525,0.0530567293021746,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.19853,-0.624,0.915,1447,0.978,"xylazine",0.0385789059335517,0.00966114521239857,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.34548,0.829,0.694,317,1,"oxprenolol, carvedilol, atipamezole, atenolol......, idazoxan",0.158640529545145,0,FALSE
+"H1650","Pearson.est","AKT inhibitor",-0.31037,-0.9,0.587,446,0.645,"palomid.529, ONC201, uprosertib, AT7867, AZD5363, MK.2206, triciribine, GSK2110183, CCT128930, A.674563, GDC.0068",0.231361898752386,0.190440285364732,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39974,0.947,0.545,510,0.988,"AZD3463, alectinib, DMH1, lorlatinib, CEP.37440",0.263603497723358,0.00524305541237188,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.35563,-1.06,0.35,1234,0.475,"enzalutamide, flutamide, RU.58841",0.455931955649724,0.323306390375133,FALSE
+"H1650","Pearson.est","antioxidant",0.45589,1.07,0.398,231,0.854,"mesna, trolox",0.400116927926312,0.068542129310995,FALSE
+"H1650","Pearson.est","AP inhibitor",-0.45002,-1.36,0.109,1216,0.526,"LCL.161, tanshinone.i, birinapant, GDC.0152",0.962573502059376,0.279014255846261,FALSE
+"H1650","Pearson.est","ATPase inhibitor",-0.44453,-1.42,0.109,1318,0.559,"rabeprazole, digitoxigenin, oligomycin.a, omeprazole, k.strophanthidin",0.962573502059376,0.252588192113577,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.56442,1.33,0.124,533,0.729,"GSK1070916, SNS.314, KW.2449, tozasertib, AT.9283, danusertib, hesperadin, alisertib, CCT129202, AMG900, barasertib, barasertib.HQPA, ENMD.2076, CCT137690, PHA.680632, PF.03814735, MK.8745, MK.5108",0.906578314837765,0.137272471682025,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30728,0.734,0.824,684,1,"valnemulin, tedizolid, tilmicosin, azalomycin.b, azithromycin",0.0840727883028842,0,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.53356,1.27,0.178,146,0.685,"finafloxacin, novobiocin",0.749579997691106,0.164309428507574,FALSE
+"H1650","Pearson.est","BCL inhibitor",0.51208,1.23,0.202,224,0.693,"gossypol, TW.37, obatoclax",0.694648630553376,0.159266765388193,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.51671,1.23,0.209,427,0.693,"GZD824, tozasertib, bafetinib, ponatinib, nilotinib, flumatinib",0.679853713888946,0.159266765388193,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",0.17413,0.42,0.991,706,0.995,"zaleplon, ZK.93423, lorazepam, ivermectin, eprinomectin, temazepam",0.00392634551472468,0.00217691925427455,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.49653,1.21,0.228,732,0.686,"bromosporine, I.BET.762, JQ1...., PFI.1, I.BET151, OTX015",0.642065152999546,0.163675884293248,FALSE
+"H1650","Pearson.est","calcium channel blocker",0.33933,0.813,0.723,342,1,"tetrandrine, cinnarazine, mibefradil",0.140861702705469,0,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",0.70818,1.69,0.0131,233,0.17,"navarixin, ZK811752, PF.04136309, SB.225002",1.88272870434424,0.769551078621726,TRUE
+"H1650","Pearson.est","CDK inhibitor",0.69186,1.64,0.0126,248,0.214,"palbociclib, AZD5438, ribociclib, indisulam, abemaciclib, alvocidib, PHA.848125, JNJ.7706621, TG.02, aminopurvalanol.a, dinaciclib, P276.00",1.89962945488244,0.669586226650809,TRUE
+"H1650","Pearson.est","CHK inhibitor",-0.43234,-1.3,0.196,623,0.514,"SB.218078, AZD7762, CHIR.124, LY2606368, SCH.900776, LY2603618, PF.477736",0.707743928643524,0.289036881004724,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",0.2703,0.644,0.904,453,1,"tepoxalin, meloxicam, FR.122047, ketoprofen, curcumin, aspirin, piroxicam, indoprofen",0.0438315695246367,0,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",0.44419,1.05,0.399,486,0.854,"morin, itraconazole, cobicistat",0.399027104313252,0.068542129310995,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.43944,1.04,0.411,482,0.854,"carmustine, melphalan, cyclophosphamide, carboplatin, temozolomide, TH.302, streptozotocin",0.386158178123931,0.068542129310995,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.39707,0.941,0.549,395,0.976,"carmustine, oxaliplatin, melphalan, carboplatin, mechlorethamine, sangivamycin, bendamustine",0.260427655549908,0.0105501823333082,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.27229,0.654,0.901,653,1,"fdcyd, disulfiram, decitabine, RG108",0.045275209020937,0,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",0.47391,1.13,0.323,457,0.77,"idoxuridine, trifluridine, adefovir.dipivoxil, foscarnet, famciclovir",0.490797477668897,0.113509274827518,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",0.44794,1.07,0.392,226,0.854,"anisomycin, floxuridine, cyclocytidine, CB.10.277",0.406713932979543,0.068542129310995,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",0.46674,1.13,0.311,280,0.77,"domperidone, amisulpride, UH.232...., sertindole, paliperidone, isofloxythepin, mesoridazine",0.507239610973163,0.113509274827518,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",0.30122,0.715,0.842,481,1,"PPT, estrone, erteberel, ethinyl.estradiol",0.0746879085003505,0,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",0.52217,1.22,0.218,456,0.689,"raloxifene, clomifene, fulvestrant",0.661543506395395,0.161780778092374,FALSE
+"H1650","Pearson.est","FGFR inhibitor",0.38321,0.91,0.587,378,0.975,"regorafenib, PD.173074, dovitinib",0.231361898752386,0.0109953843014632,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.57249,1.36,0.113,436,0.838,"gilteritinib, KW.2449, tozasertib, ponatinib, TG.02, pacritinib, lestaurtinib, TG.101348, ENMD.2076, dovitinib, sunitinib",0.94692155651658,0.0767559813697235,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",0.55703,1.34,0.137,407,0.758,"hydrocortisone, prednisolone, ciclesonide, fluocinolone.acetonide, triamcinolone.acetonide, rimexolone, halobetasol.propionate, difluprednate, methylprednisolone, desonide, fluticasone.propionate, flumethasone.pivalate, halcinonide, triamcinolone, prednisolone.acetate",0.863279432843593,0.120330794367946,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",0.29918,0.714,0.843,160,1,"diazooxonorleucine, SIB.1757",0.0741724253752577,0,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.3524,0.848,0.669,615,1,"tideglusib, TWS.119, CHIR.99021, kenpaullone, AZD2858",0.174573882232177,0,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.65866,1.57,0.0297,327,0.304,"GSK1838705A, AZD3463, PHA.848125, danusertib, lestaurtinib, GSK1904529A",1.52724355068279,0.517126416391246,FALSE
+"H1650","Pearson.est","HCV inhibitor",0.41615,0.992,0.493,600,0.927,"embelin, PSI.7976, mericitabine",0.30715308072277,0.0329202658555029,FALSE
+"H1650","Pearson.est","HDAC inhibitor",0.22243,0.543,0.952,555,1,"PCI.24781, givinostat, trichostatin.a, panobinostat, AR.42, resminostat, belinostat, entinostat, dacinostat, R306465",0.0213630516155257,0,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",0.2411,0.575,0.951,923,1,"pheniramine, astemizole, tiotidine, ranitidine, ICI.162846, epinastine, BF2.649, zolantidine, levocetirizine, famotidine, tecastemizole, cimetidine, nizatidine, cyproheptadine",0.0218194830625861,0,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.41401,-1.27,0.195,597,0.413,"lovastatin, simvastatin, atorvastatin, mevastatin, fluvastatin, pitavastatin",0.709965388637482,0.384049948343599,FALSE
+"H1650","Pearson.est","HSP inhibitor",-0.35367,-1.07,0.323,1294,0.502,"VER.49009, tanespimycin, guanidine, alvespimycin, KW.2478",0.490797477668897,0.299296282854981,FALSE
+"H1650","Pearson.est","JAK inhibitor",0.49631,1.18,0.27,431,0.713,"atiprimod, TG.101209, tozasertib, AZ960, TG.02, AT.9283, pacritinib, lestaurtinib, TG.101348, AZD1480, filgotinib",0.568636235841013,0.146910470148134,FALSE
+"H1650","Pearson.est","KIT inhibitor",0.39485,0.928,0.566,149,0.958,"KI.8751, regorafenib, OSI.930",0.247183568811729,0.0186344909214556,FALSE
+"H1650","Pearson.est","MDM inhibitor",0.82133,1.94,0,180,0.0323,"idasanutlin, nutlin.3, serdemetan, CGM097, AMG.232",Inf,1.4907974776689,TRUE
+"H1650","Pearson.est","MEK inhibitor",0.86838,2.1,0,96,0.00468,"cobimetinib, AZD8330, AS.703026, PD.0325901, trametinib, TAK.733, MEK162, Ro.4987655, selumetinib, PD.318088, refametinib, PD.198306, PD.184352",Inf,2.32975414692588,TRUE
+"H1650","Pearson.est","MET inhibitor",0.33916,0.808,0.71,678,1,"PHA.665752, LY2801653, AMG458",0.148741651280925,0,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.31595,0.756,0.796,608,1,"vinflunine, podophyllotoxin, vinblastine, D.64131, triclabendazole, secnidazole",0.0990869322623309,0,FALSE
+"H1650","Pearson.est","mTOR inhibitor",0.36306,0.853,0.689,463,1,"XL388, WAY.600, ku.0063794, LY303511, WYE.354, torin.1, PF.04691502, PP242, OSI.027, palomid.529, GSK2126458, voxtalisib, AZD8055",0.161780778092374,0,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",0.27807,0.663,0.89,621,1,"bortezomib, curcumin, betulinic.acid, parthenolide...., EVP4593, parthenolide",0.0506099933550872,0,FALSE
+"H1650","Pearson.est","opioid receptor agonist",0.49789,1.18,0.251,562,0.713,"trimebutine, salvinorin.a, cebranopadol",0.600326278518962,0.146910470148134,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.44356,1.06,0.401,696,0.854,"skepinone.l, SB.242235, VX.702, TAK.715, CMPD.1",0.396855627379818,0.068542129310995,FALSE
+"H1650","Pearson.est","PARP inhibitor",0.54492,1.29,0.159,333,0.707,"talazoparib, niraparib, AG.14361",0.798602875679548,0.150580586203101,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.23349,0.561,0.949,448,1,"KI.8751, regorafenib, ponatinib, dovitinib, sunitinib, crenolanib",0.0227337875727074,0,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",0.24877,0.592,0.941,225,1,"GSK2830371, sodium.stibogluconate",0.0264103765727431,0,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",-0.33171,-0.984,0.428,477,0.553,"avanafil, GSK256066, EMD.53998, anagrelide, zardaverine, cilostamide, YM.976, trequinsin, papaverine, enoximone",0.368556230986828,0.257274868695302,FALSE
+"H1650","Pearson.est","PI3K inhibitor",0.3958,0.931,0.564,503,0.975,"YM.201636, LY303511, buparlisib, PIK.75, ZSTK.474, GDC.0941, AZD6482, PF.04691502, GSK2126458, voxtalisib, TG.100713",0.248720896016658,0.0109953843014632,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.62742,1.48,0.0734,296,0.487,"rigosertib, NMS.1286937, volasertib, GSK461364",1.13430394008393,0.312471038785366,FALSE
+"H1650","Pearson.est","potassium channel blocker",-0.38488,-1.18,0.252,555,0.485,"meglitinide, oleoylethanolamide, ML133, ibutilide, mepivacaine, dofetilide",0.598599459218456,0.314258261397736,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",-0.38793,-1.15,0.265,559,0.477,"ciprofibrate, oleoylethanolamide, fenofibrate, clofibrate, S26948, pterostilbene, GW.501516",0.576754126063192,0.321481620959886,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",0.32588,0.774,0.755,426,1,"melengestrol.acetate, nomegestrol.acetate, tanaproget",0.122053048370812,0,FALSE
+"H1650","Pearson.est","proteasome inhibitor",0.20868,0.498,0.979,563,1,"bortezomib, ixazomib, MG.132",0.00921730819686218,0,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.41826,0.988,0.493,120,0.912,"brefeldin.a, cycloheximide, homoharringtonine",0.30715308072277,0.0400051616715838,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.29662,0.699,0.842,57,1,"NVP.TAE226",0.0746879085003505,0,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.74518,1.76,0.00585,144,0.106,"AZ.628, dabrafenib, CEP.32496, GDC.0879, LGX818, SB.590885, vemurafenib, regorafenib",2.23284413391782,0.97469413473523,TRUE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.48011,1.14,0.284,670,0.801,"regorafenib, sunitinib, sorafenib, vandetanib",0.546681659952962,0.0963674839157623,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.4206,1,0.482,281,0.933,"tamibarotene, CD.437, adarotene",0.31695296176115,0.0301183562535,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.54497,1.3,0.165,331,0.723,"LY2334737, triapine, clofarabine, fludarabine.phosphate, cladribine",0.782516055786094,0.140861702705469,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",0.28963,0.693,0.849,855,1,"NAN.190, ipsapirone, aripiprazole, SR.57227A, zolmitriptan",0.0710923097560473,0,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",0.55315,1.34,0.126,274,0.758,"pirenperone, sertindole, paliperidone, SB.216641, SB.200646, lerisetron",0.899629454882437,0.120330794367946,FALSE
+"H1650","Pearson.est","sodium channel blocker",0.32985,0.785,0.75,419,1,"ajmaline, mexiletine, benzethonium, quinidine, butamben",0.1249387366083,0,FALSE
+"H1650","Pearson.est","src inhibitor",0.27796,0.668,0.891,51,1,"PP.2",0.0501222959631252,0,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",-0.38003,-1.13,0.256,548,0.455,"terconazole, posaconazole, lanoconazole, ketoconazole, sulconazole, chlormidazole",0.59176003468815,0.341988603342888,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.42718,-1.28,0.155,616,0.464,"SB.525334, D.4476, adaprev, SB.431542, repsox, LY2109761",0.809668301829709,0.333482019445119,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.75588,1.79,0.0034,295,0.109,"carmofur, raltitrexed, trifluridine, ftorafur",2.46852108295775,0.962573502059376,TRUE
+"H1650","Pearson.est","topoisomerase inhibitor",0.38246,0.899,0.601,681,0.976,"amsacrine, topotecan, fleroxacin, idarubicin, voreloxin, teniposide, TAS.103, SN.38, exatecan.mesylate, rubitecan, daunorubicin, valrubicin, nemorubicin, doxorubicin, genz.644282, licochalcone.a",0.22112552799726,0.0105501823333082,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.52319,1.25,0.206,479,0.706,"verubulin, indibulin, albendazole, fosbretabulin, oxibendazole, parbendazole, podophyllotoxin, nocodazole, vindesine, vinorelbine, vinblastine, epothilone.b, BNC105, combretastatin.A.4, taltobulin, plinabulin, vincristine, dolastatin.10",0.686132779630847,0.151195298948196,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.31444,0.758,0.769,708,1,"NVP.TAE226, regorafenib, bafetinib, aminopurvalanol.a, tivantinib, UNC2250, sunitinib, tyrphostin.A9, PP.121, hypericin, sorafenib, vandetanib, dasatinib",0.114073660198569,0,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.19227,0.457,0.983,796,1,"KI.8751, regorafenib, OSI.930, PD.173074, ENMD.2076, TG.100572, dovitinib, sunitinib, RAF265, sorafenib, golvatinib, vandetanib, axitinib, semaxanib, MK.2461, SAR131675, orantinib, vatalanib, pazopanib",0.00744648216786438,0,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.51224,-1.63,0.0192,1326,0.725,"calcitriol, maxacalcitol",1.71669877129645,0.139661993429006,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",-0.82172,-2.01,0,1330,0.0316,"CNX.2006, CUDC.101, TAK.285, PD.168393, GW.583340, BMS.599626, WZ8040, brigatinib, AST.1306, WZ.3146, icotinib, WZ.4002, BIBX.1382, ARRY.334543, CP.724714, AEE788, pelitinib, BMS.690514, tucatinib, rociletinib, lapatinib, neratinib, AZD8931, dacomitinib, osimertinib, erlotinib, XL.647, gefitinib, afatinib, canertinib, poziotinib",Inf,1.5003129173816,TRUE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.37517,-0.915,0.568,1227,0.85,"metatinib, bosutinib, ZM.306416",0.245651664288981,0.0705810742857073,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.52402,1.42,0.135,407,0.303,"tremorine, nefiracetam, oxiracetam, nicotine, pilocarpine",0.869666231504994,0.518557371497695,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",0.46524,1.29,0.161,19,0.395,"iododexetimide",0.79317412396815,0.40340290437354,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",-0.54128,-1.33,0.147,1443,0.455,"CGS.15943",0.832682665251824,0.341988603342888,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",0.37474,1.03,0.411,386,0.558,"ritodrine, isoxsuprine, isoetharine, oxymetazoline, norepinephrine, epinephrine, xylazine",0.386158178123931,0.253365801062421,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",-0.22971,-0.571,0.932,1081,1,"dihydroergocristine, vincamine, carvedilol, RS.17053, imiloxan",0.0305840876460186,0,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.60551,-1.45,0.0902,1305,0.361,"CCT128930, GDC.0068, triciribine, uprosertib",1.04479346245806,0.442492798094342,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.73298,-1.78,0.0147,1246,0.134,"SB.505124, CEP.37440, alectinib, NVP.TAE684, AZD3463, brigatinib",1.83268266525182,0.872895201635192,TRUE
+"HCC95","Pearson.est","androgen receptor antagonist",0.63795,1.67,0.0458,222,0.201,"bicalutamide, enzalutamide",1.33913452199613,0.696803942579511,TRUE
+"HCC95","Pearson.est","antioxidant",0.74347,2.06,0,200,0.0553,"benfotiamine, chlorogenic.acid, trolox, mesna",Inf,1.2572748686953,TRUE
+"HCC95","Pearson.est","AP inhibitor",0.41269,1.15,0.277,22,0.442,"idronoxil",0.557520230935551,0.354577730650908,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",-0.5272,-1.27,0.186,1057,0.497,"digitoxigenin, omeprazole, evodiamine, digoxin, oligomycin.a, NMS.873, k.strophanthidin, rabeprazole",0.730487055782084,0.303643611266668,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",-0.65344,-1.59,0.0318,1085,0.271,"barasertib, GSK1070916, CCT137690, PF.03814735, MK.5108, alisertib, aurora.a.inhibitor.i, ENMD.2076, CCT129202, hesperadin, MLN.8054, MK.8745, CYC116, ZM.447439, TAK.901, danusertib, barasertib.HQPA, PHA.680632",1.49757288001557,0.567030709125594,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45658,-1.12,0.318,1024,0.646,"tedizolid, valnemulin, azithromycin, radezolid",0.497572880015567,0.189767482004916,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.56518,1.58,0.0733,116,0.225,"nadifloxacin, novobiocin, sparfloxacin",1.13489602535887,0.647817481888638,FALSE
+"HCC95","Pearson.est","BCL inhibitor",0.53749,1.47,0.107,400,0.279,"oridonin, venetoclax, ABT.737, navitoclax, gossypol",0.97061622231479,0.554395796726402,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.24612,-0.59,0.909,1227,1,"metatinib, bosutinib",0.0414361167780325,0,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.20328,-0.498,0.981,1064,1,"ZK.93423, ivermectin, bentazepam",0.0083309926200515,0,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",-0.5225,-1.3,0.193,1029,0.463,"JQ1...., I.BET151, OTX015, I.BET.762",0.714442690992226,0.334419008982047,FALSE
+"HCC95","Pearson.est","calcium channel blocker",-0.42758,-1.06,0.373,873,0.691,"tetrandrine, fendiline, carboxyamidotriazole, efonidipine.monoethanolate, penfluridol",0.428291168191312,0.160521952625802,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.25951,-0.63,0.906,1044,1,"MK.0812, SB.225002, ZK811752",0.0428718023231869,0,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.60637,-1.47,0.0849,1012,0.386,"CR8..R., ribociclib, palbociclib, PHA.848125, dinaciclib, alvocidib, TG.02, aminopurvalanol.a, R547, arcyriaflavin.a, JNJ.7706621, indisulam, BMS.265246, PHA.793887, BMS.387032, AT.7519",1.07109230975605,0.413412695328245,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.39923,-0.975,0.489,765,0.784,"AZD7762, PF.477736, CHIR.124, LY2603618, SB.218078",0.31069114087638,0.105683937315562,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.1866,-0.455,0.991,787,1,"indoprofen, sulfasalazine, curcumin, piroxicam, aspirin, phenazone, FR.122047, ramifenazone, FK.3311, tryptanthrin, amfenac",0.00392634551472468,0,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.62507,1.79,0.0261,181,0.167,"metyrapone, morin, clotrimazole",1.58335949266172,0.777283528852417,TRUE
+"HCC95","Pearson.est","DNA alkylating agent",-0.28241,-0.687,0.819,1096,1,"cyclophosphamide, mitomycin.c, estramustine, dacarbazine",0.0867160982395816,0,FALSE
+"HCC95","Pearson.est","DNA inhibitor",0.37521,1.02,0.411,248,0.524,"nimorazole, metronidazole, carboplatin, bendamustine, pibenzimol, nithiamide, carmustine",0.386158178123931,0.280668713016273,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.66148,-1.59,0.042,1146,0.271,"fdcyd, SGI.1027, azacitidine, decitabine",1.3767507096021,0.567030709125594,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",-0.2787,-0.678,0.859,1380,1,"cephalomannine",0.0660068361687577,0,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.41843,-1.03,0.427,1211,0.727,"mitomycin.c, anisomycin, cyclocytidine, enocitabine",0.369572124974976,0.138465589140962,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",0.22873,0.63,0.87,144,1,"amisulpride, clebopride, ziprasidone",0.0604807473813815,0,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.3061,-0.738,0.765,1362,1,"levonorgestrel",0.116338564846382,0,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",0.42984,1.18,0.257,92,0.428,"danazol, toremifene",0.590066876668705,0.368556230986828,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",0.21958,0.616,0.898,202,0.977,"erdafitinib, orantinib",0.0467236633326956,0.0101054362812269,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",0.20475,0.556,0.962,397,0.987,"GTP.14564, ponatinib, gilteritinib, midostaurin, KW.2449, dovitinib, tyrphostin.AG.1296, tandutinib",0.0168249279621871,0.00568284733036327,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.40631,-0.988,0.459,1001,0.784,"betamethasone, methylprednisolone, halcinonide, difluprednate, clobetasol.propionate, flumethasone.pivalate, deflazacort, beclomethasone.dipropionate, triamcinolone.acetonide, halobetasol.propionate, ciclesonide, flumethasone, fluorometholone",0.338187314462739,0.105683937315562,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",-0.17529,-0.424,0.997,1344,0.995,"LY456236",0.00130484168834428,0.00217691925427455,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.73408,2.03,0,130,0.0522,"CHIR.98014, CHIR.99021, GSK.3.inhibitor.IX, tideglusib, LY2090314",Inf,1.28232949699774,TRUE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.55436,-1.33,0.161,935,0.455,"lestaurtinib, PHA.848125, GSK1838705A, danusertib, AZD3463",0.79317412396815,0.341988603342888,FALSE
+"HCC95","Pearson.est","HCV inhibitor",0.24965,0.668,0.869,1088,0.993,"Ro.9187, embelin, mericitabine, daclatasvir, PSI.7976, narlaprevir",0.0609802235513335,0.00305075150461883,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.38257,-0.928,0.537,847,0.851,"resminostat, R306465, RGFP966, chidamide, AR.42, belinostat, ACY.1215, M.344, trichostatin.a, NSC.3852, scriptaid, vorinostat, PCI.24781, JNJ.26481585, givinostat, dacinostat, SB.939",0.270025714300444,0.0700704399154121,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",0.12867,0.35,1,1264,1,"epinastine, lafutidine, chloropyramine, nizatidine, famotidine, ICI.162846, cimetidine, pheniramine, tecastemizole, astemizole, ranitidine, tiotidine, cyproheptadine, zolantidine, BF2.649, terfenadine, levocetirizine, ebastine",0,0,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.9154,2.5,0,128,0,"lovastatin, pitavastatin, fluvastatin, mevastatin, atorvastatin, simvastatin",Inf,Inf,TRUE
+"HCC95","Pearson.est","HSP inhibitor",-0.58608,-1.4,0.116,931,0.375,"ganetespib, XL888, VER.49009, alvespimycin, NVP.AUY922, BIIB021, KW.2478, tanespimycin, PU.H71",0.935542010773082,0.425968732272281,FALSE
+"HCC95","Pearson.est","JAK inhibitor",-0.53095,-1.31,0.193,1008,0.468,"baricitinib, AT.9283, LY2784544, WHI.P154, TG.02, AZD1480, ruxolitinib, AZ960, pacritinib, filgotinib, PRT062070",0.714442690992226,0.329754146925876,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.19135,-0.465,0.993,1033,1,"lenvatinib, vatalanib, cediranib, OSI.930",0.00305075150461883,0,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.85188,2.36,0,71,0.00404,"AMG.232, idasanutlin, CGM097, nutlin.3",Inf,2.3936186348894,TRUE
+"HCC95","Pearson.est","MEK inhibitor",0.43088,1.18,0.267,392,0.428,"refametinib, BIX.02188, cobimetinib, U.0126, TAK.733, MEK1.2.inhibitor, PD.184352, MEK162",0.573488738635425,0.368556230986828,FALSE
+"HCC95","Pearson.est","MET inhibitor",0.60658,1.68,0.0458,213,0.226,"PHA.665752, NVP.BVU972, AMG458",1.33913452199613,0.645891560852599,TRUE
+"HCC95","Pearson.est","microtubule inhibitor",-0.59596,-1.46,0.0804,1139,0.373,"podophyllotoxin, colchicine, vinflunine, cabazitaxel, D.64131",1.09474395125155,0.428291168191312,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.45945,-1.12,0.329,1056,0.646,"PP242, torin.1, MLN0128, WYE.125132, torin.2, deforolimus, AZD8055, PI.103, GDC.0980, WYE.354, GSK2126458, PF.05212384",0.482804102050026,0.189767482004916,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",-0.20611,-0.5,0.983,832,1,"curcumin, parthenolide...., IKK.2.inhibitor.V, parthenolide, Ro.106.9920, EVP4593",0.00744648216786438,0,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",0.49728,1.33,0.166,103,0.373,"BW.180C, ADL5859",0.779891911959945,0.428291168191312,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",-0.58875,-1.41,0.103,1240,0.381,"CMPD.1, SB.239063, talmapimod",0.987162775294828,0.419075024324381,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.36089,-0.872,0.62,907,0.908,"AZD2461, olaparib, PJ.34, niraparib, talazoparib",0.207608310501746,0.0419141514789149,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.2569,0.705,0.784,464,0.976,"KI.8751, orantinib, ponatinib, linifanib, dovitinib, CP.673451, telatinib, tandutinib, pazopanib, sunitinib, regorafenib, trapidil",0.105683937315562,0.0105501823333082,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.45718,1.25,0.212,232,0.418,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, menadione, CID.5458317",0.673664139071249,0.378823718224965,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.37454,1.02,0.41,121,0.524,"anagrelide, GSK256066, enoximone",0.387216143280265,0.280668713016273,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.49432,-1.19,0.253,1196,0.604,"TG.100713, PI.103, GDC.0980, PIK.75, GSK2126458, CH5132799, PF.05212384, alpelisib, taselisib",0.596879478824182,0.218963061378868,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.814,-1.97,0,1348,0.0307,"GW.843682X, HMN.214, BI.2536, volasertib, NMS.1286937",Inf,1.51286162452281,TRUE
+"HCC95","Pearson.est","potassium channel blocker",0.3966,1.13,0.308,212,0.444,"meglitinide, ML133",0.511449283499556,0.35261702988538,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.57999,1.62,0.0655,132,0.219,"fenofibrate, S26948, clofibrate",1.18375870000822,0.659555885159882,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",0.54867,1.48,0.1,198,0.297,"norethindrone, nomegestrol.acetate, danazol, norethindrone.acetate, norgestrel",1,0.527243550682788,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",-0.44815,-1.07,0.368,1178,0.696,"carfilzomib",0.434152181326482,0.157390760389438,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",-0.51442,-1.22,0.22,1181,0.57,"thiostrepton, cycloheximide, harringtonine, anguidine, puromycin, homoharringtonine, tedizolid.phosphate, bruceantin",0.657577319177794,0.244125144327509,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.74314,-1.78,0.00855,1372,0.134,"BMS.599626, NVP.TAE226, CP.724714, AV.412",2.06803388527183,0.872895201635192,TRUE
+"HCC95","Pearson.est","RAF inhibitor",0.44794,1.24,0.235,35,0.403,"dabrafenib, vemurafenib",0.628932137728264,0.39469495385889,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.32328,-0.791,0.708,1037,1,"cabozantinib, vandetanib",0.149966742310231,0,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.35302,-0.86,0.627,971,0.905,"adarotene, bexarotene, adapalene, CD.437",0.202732459169284,0.0433514207947967,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.30177,0.832,0.625,241,0.794,"pentostatin, hydroxyurea, fludarabine",0.204119982655925,0.100179497572904,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.65005,-1.57,0.0427,1238,0.27,"zolmitriptan, pardoprunox, aripiprazole",1.36957212497498,0.568636235841013,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",-0.31608,-0.766,0.763,1436,1,"aripiprazole",0.11747546204512,0,FALSE
+"HCC95","Pearson.est","sodium channel blocker",-0.24539,-0.589,0.927,960,1,"benzethonium, triamterene, lappaconite, A.803467, brivaracetam",0.0329202658555029,0,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.71705,-1.73,0.0171,1369,0.157,"bosutinib, saracatinib, ZM.306416",1.76700388960785,0.804100347590766,TRUE
+"HCC95","Pearson.est","sterol demethylase inhibitor",-0.23717,-0.582,0.918,342,1,"posaconazole, terconazole, ketoconazole, chlormidazole, sulconazole, lanoconazole",0.0371573187987575,0,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.60175,-1.47,0.0727,1083,0.386,"adaprev, SB.525334, D.4476, repsox",1.13846558914096,0.413412695328245,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.24124,-0.593,0.905,1268,1,"carmofur",0.0433514207947967,0,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",-0.43995,-1.07,0.395,798,0.696,"licochalcone.a, epirubicin, voreloxin, valrubicin, teniposide, idarubicin, daunorubicin, beta.lapachone, etoposide, amsacrine, TAS.103, irinotecan, mitoxantrone, genz.644282, amonafide, camptothecin, SN.38, exatecan.mesylate, dexrazoxane",0.40340290437354,0.157390760389438,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.6977,-1.68,0.0192,1139,0.198,"podophyllotoxin, combretastatin.A.4, flubendazole, indibulin, CYT.997, plinabulin, albendazole, fenbendazole, vincristine, mebendazole, dolastatin.10, fosbretabulin, taltobulin, nocodazole, ABT.751, vinorelbine, epothilone.b, parbendazole, docetaxel, paclitaxel",1.71669877129645,0.703334809738469,TRUE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.46455,-1.12,0.336,1372,0.646,"BMS.599626, NVP.TAE226, CP.724714, AV.412, tivantinib",0.473660722610156,0.189767482004916,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.47148,-1.15,0.289,933,0.662,"SAR131675, RAF265, TG.100572, golvatinib, foretinib, semaxanib, lenvatinib, cabozantinib, SU014813, vatalanib, cediranib, ENMD.2076, PD.173074, lucitanib, vandetanib, OSI.930, ZM.306416, AEE788, BMS.690514, XL.647",0.539102157243452,0.1791420105603,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",-0.58103,-1.44,0.102,846,0.353,"ercalcitriol, calcitriol, doxercalciferol, paricalcitol, tacalcitol, maxacalcitol",0.991399828238082,0.452225294612177,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.75378,1.74,0.0062,170,0.215,"gefitinib, poziotinib, AZD8931, afatinib, AST.1306, neratinib, dacomitinib, erlotinib, pelitinib, XL.647, BIBU.1361, CUDC.101, lapatinib, osimertinib, BMS.690514, canertinib, ARRY.334543, vandetanib, WZ.4002, tucatinib, CNX.2006, PD.153035, BIBX.1382, AEE788, BMS.599626, icotinib",2.20760831050175,0.667561540084395,TRUE
+"H1975","Pearson.est","Abl kinase inhibitor",0.44677,1.06,0.405,666,0.769,"ZM.306416, dasatinib, bosutinib, bafetinib, nilotinib, GZD824, imatinib, tozasertib",0.392544976785331,0.114073660198569,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",0.31852,0.738,0.792,634,0.941,"pilocarpine, tremorine, xanomeline, oxiracetam",0.101274818410506,0.0264103765727431,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",-0.3726,-1.03,0.407,1262,0.869,"iododexetimide, methscopolamine",0.39040559077478,0.0609802235513335,FALSE
+"H1975","Pearson.est","adenosine receptor antagonist",0.53704,1.27,0.188,399,0.549,"CGS.15943, PSB.1115, istradefylline, MRS.1220, SCH.58261, sulmazole",0.72584215073632,0.260427655549908,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",-0.42733,-1.23,0.165,1186,0.749,"clenbuterol, midodrine, epinephrine, A61603, norepinephrine, lidamidine, xylazine",0.782516055786094,0.125518182300534,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.2973,0.689,0.845,567,0.94,"atenolol......, dihydroergocristine, dronedarone, oxprenolol, imiloxan, idazoxan, practolol, naftidrofuryl, prazosin",0.0731432910503077,0.0268721464003014,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.42379,0.995,0.475,438,0.76,"uprosertib, triciribine, palomid.529, GDC.0068, GSK2110183",0.323306390375133,0.119186407719209,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41655,0.969,0.521,727,0.749,"AZD3463, alectinib, CEP.37440, SB.505124, NVP.TAE684, brigatinib, crizotinib, DMH1, lorlatinib",0.283162276700476,0.125518182300534,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",-0.32119,-0.878,0.551,1255,0.943,"enzalutamide, flutamide",0.258848401148215,0.0254883072626717,FALSE
+"H1975","Pearson.est","antioxidant",-0.35198,-1.01,0.369,1332,0.853,"taurine, rutin",0.43297363384094,0.069050968832477,FALSE
+"H1975","Pearson.est","AP inhibitor",-0.71291,-2.1,0,1426,0.081,"birinapant, LCL.161, GDC.0152",Inf,1.09151498112135,TRUE
+"H1975","Pearson.est","ATPase inhibitor",-0.39797,-1.14,0.263,1224,0.724,"oligomycin.a, blebbistatin...., ouabain, digitoxigenin, digitoxin, omeprazole",0.580044251510242,0.140261433802853,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",0.42594,1,0.448,690,0.795,"ENMD.2076, PHA.680632, danusertib, CCT137690, hesperadin, barasertib.HQPA, CCT129202, GSK1070916, alisertib, AT.9283, CYC116, SNS.314, barasertib, tozasertib, MK.8745, PF.03814735",0.348721986001856,0.0996328713435297,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.42094,0.966,0.521,600,0.716,"azithromycin, azalomycin.b, tilmicosin, tedizolid, valnemulin, radezolid",0.283162276700476,0.145086977692144,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.30415,-0.851,0.632,1428,0.864,"sparfloxacin",0.199282921717615,0.0634862575211067,FALSE
+"H1975","Pearson.est","BCL inhibitor",0.63111,1.45,0.0754,166,0.557,"obatoclax, gossypol, TW.37",1.12262865413023,0.254144804826271,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",0.43761,1.03,0.423,666,0.783,"dasatinib, bosutinib, bafetinib, nilotinib, GZD824, imatinib, tozasertib",0.373659632624958,0.106238237942057,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.27345,0.626,0.912,377,0.944,"eprinomectin, zaleplon, ZK.93423, piperazine",0.0400051616715838,0.025028005701931,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",0.71298,1.67,0.0114,303,0.265,"JQ1...., I.BET151, bromosporine, OTX015, I.BET.762",1.94309514866353,0.576754126063192,FALSE
+"H1975","Pearson.est","calcium channel blocker",0.47116,1.09,0.353,256,0.783,"tetrandrine, cinnarazine, mibefradil",0.452225294612177,0.106238237942057,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",0.46866,1.09,0.358,648,0.783,"ZK811752, SB.225002, PF.04136309, navarixin",0.446116973356126,0.106238237942057,FALSE
+"H1975","Pearson.est","CDK inhibitor",0.56804,1.3,0.155,556,0.509,"TG.02, P276.00, R547, JNJ.7706621, indisulam, ribociclib, aminopurvalanol.a, PHA.848125, AZD5438, palbociclib, alvocidib, indirubin, BMS.387032, arcyriaflavin.a, AT.7519, NU6027, dinaciclib, abemaciclib",0.809668301829709,0.293282217663241,FALSE
+"H1975","Pearson.est","CHK inhibitor",0.30654,0.707,0.846,781,0.939,"AZD7762, SB.218078, LY2603618, CHIR.124, PF.477736",0.0726296369609765,0.0273344077338891,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.20462,-0.592,0.908,1236,1,"amfenac, acetylsalicylsalicylic.acid, naproxen, AM.404, suxibuzone, metoxibutropate",0.0419141514789149,0,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.28623,-0.809,0.674,1244,0.903,"eplerenone, clotrimazole",0.17134010346468,0.0443122496864942,FALSE
+"H1975","Pearson.est","DNA alkylating agent",-0.19577,-0.535,0.979,1259,1,"carboplatin, dianhydrogalactitol, cisplatin",0.00921730819686218,0,FALSE
+"H1975","Pearson.est","DNA inhibitor",0.37094,0.865,0.642,684,0.815,"mechlorethamine, oxaliplatin, bendamustine, carmustine, nimorazole, sangivamycin, valrubicin, melphalan, nithiamide, busulfan",0.192464971931147,0.0888423912600234,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.59498,1.38,0.0907,213,0.531,"fdcyd, azacitidine, disulfiram",1.0423927129399,0.274905478918531,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",0.44102,1.04,0.426,333,0.786,"idoxuridine, adefovir.dipivoxil, trifluridine, cidofovir",0.370590400897281,0.104577453960592,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",0.32948,0.764,0.781,366,0.949,"anisomycin, enocitabine, cyclocytidine, floxuridine, CB.10.277",0.1073489661227,0.0227337875727074,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",0.42308,0.997,0.468,125,0.778,"mesoridazine, sertindole, domperidone",0.329754146925876,0.109020403010311,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.31695,-0.896,0.538,1386,0.953,"estradiol, estradiol.cypionate",0.269217724333611,0.0209070993616736,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",0.45424,1.07,0.385,289,0.774,"clomifene, raloxifene",0.414539270491499,0.111259039317107,FALSE
+"H1975","Pearson.est","FGFR inhibitor",0.32505,0.755,0.801,335,0.939,"regorafenib, PD.173074, dovitinib",0.0963674839157623,0.0273344077338891,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",0.4293,0.993,0.483,666,0.742,"pacritinib, TG.02, ENMD.2076, dovitinib, TG.101348, gilteritinib, sorafenib, GTP.14564, quizartinib, lestaurtinib, sunitinib, tozasertib",0.316052869248488,0.129596094720973,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",0.70775,1.63,0.0201,234,0.279,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate, desonide, halobetasol.propionate, rimexolone, methylprednisolone, halcinonide, fluocinolone.acetonide, flumethasone.pivalate, prednisolone, clobetasol.propionate, deflazacort, prednisolone.acetate, fludroxycortide, triamcinolone",1.69680394257951,0.554395796726402,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",0.25863,0.598,0.9,176,0.929,"CPP, CGP.37849",0.0457574905606751,0.0319842860063582,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.30987,-0.867,0.575,1192,0.873,"tideglusib, CHIR.99021, CHIR.98014",0.24033215531037,0.0589857562944303,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",0.58508,1.36,0.127,577,0.494,"danusertib, AZD3463, GSK1838705A, PHA.848125, GSK1904529A, lestaurtinib",0.896196279044043,0.306273051076353,FALSE
+"H1975","Pearson.est","HCV inhibitor",0.3914,0.92,0.575,231,0.743,"embelin",0.24033215531037,0.129011186239425,FALSE
+"H1975","Pearson.est","HDAC inhibitor",0.41467,0.967,0.508,456,0.732,"PCI.24781, givinostat, AR.42, trichostatin.a, M.344, RGFP966, R306465, dacinostat, belinostat, scriptaid, NSC.3852, vorinostat, SB.939",0.294136287716081,0.135488918941608,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",-0.20597,-0.569,0.939,1228,1,"zolantidine, tiotidine, cimetidine, lafutidine, chloropyramine",0.0273344077338891,0,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.8444,-2.41,0,1281,0.0088,"atorvastatin, fluvastatin, pitavastatin, mevastatin",Inf,2.05551732784983,TRUE
+"H1975","Pearson.est","HSP inhibitor",-0.52195,-1.49,0.0739,1091,0.501,"BIIB021, PU.H71, NMS.E973, ganetespib, NVP.AUY922, guanidine, KW.2478, alvespimycin",1.13135556160517,0.300162274132754,FALSE
+"H1975","Pearson.est","JAK inhibitor",0.4837,1.12,0.329,360,0.807,"pacritinib, atiprimod, TG.02, AZ960, TG.101209, AZD1480, LY2784544, TG.101348",0.482804102050026,0.0931264652779296,FALSE
+"H1975","Pearson.est","KIT inhibitor",0.26704,0.621,0.921,653,0.93,"OSI.930, regorafenib, dasatinib, sorafenib, masitinib, imatinib, sunitinib",0.0357403698031511,0.0315170514460649,FALSE
+"H1975","Pearson.est","MDM inhibitor",0.75333,1.75,0.00493,222,0.393,"nutlin.3, idasanutlin, RITA, CGM097, serdemetan",2.30715308072277,0.405607449624573,FALSE
+"H1975","Pearson.est","MEK inhibitor",0.66147,1.56,0.0418,107,0.38,"cobimetinib, AS.703026, trametinib, PD.0325901, AZD8330, selumetinib, TAK.733, Ro.4987655, MEK162",1.37882371822496,0.42021640338319,FALSE
+"H1975","Pearson.est","MET inhibitor",-0.62097,-1.72,0.0591,1261,0.27,"PF.04217903, LY2801653",1.22841251911874,0.568636235841013,FALSE
+"H1975","Pearson.est","microtubule inhibitor",-0.38804,-1.08,0.335,558,0.808,"podophyllotoxin, D.64131, secnidazole, triclabendazole, vinflunine, colchicine, cabazitaxel, estramustine.phosphate, vinblastine, cytochalasin.b",0.474955192963155,0.0925886392254138,FALSE
+"H1975","Pearson.est","mTOR inhibitor",0.60923,1.42,0.1,364,0.519,"GSK2126458, WAY.600, WYE.354, AZD8055, XL388, WYE.125132, PP242, OSI.027, voxtalisib, LY303511, AZD2014, torin.2, PF.04691502, torin.1, GDC.0980, palomid.529",1,0.284832642151542,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",0.27781,0.648,0.912,363,0.942,"EVP4593, curcumin, betulinic.acid",0.0400051616715838,0.0259490972071227,FALSE
+"H1975","Pearson.est","opioid receptor agonist",-0.40275,-1.14,0.28,1312,0.724,"ADL5859, BW.180C, spiradoline",0.552841968657781,0.140261433802853,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",0.58902,1.38,0.1,565,0.531,"SB.242235, CMPD.1, skepinone.l, talmapimod, SB.239063, VX.702",1,0.274905478918531,FALSE
+"H1975","Pearson.est","PARP inhibitor",-0.32294,-0.908,0.522,1372,0.982,"olaparib, E7449",0.282329496997738,0.00788851221305034,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.27858,-0.792,0.762,1257,0.897,"motesanib, trapidil, nintedanib, SU014813, CP.673451, linifanib",0.1180450286604,0.0472075569559079,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",0.28426,0.654,0.866,637,0.956,"alexidine, mycophenolic.acid, mycophenolate.mofetil, sodium.stibogluconate, CID.5458317, GSK2830371",0.0624821079826534,0.0195421077238999,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",-0.32359,-0.953,0.469,1177,0.932,"zardaverine, anagrelide, YM.976, GSK256066, enoximone",0.328827157284917,0.0305840876460186,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.56867,1.34,0.132,526,0.508,"GSK2126458, taselisib, YM.201636, GDC.0941, alpelisib, buparlisib, voxtalisib, PI3K.IN.2, LY303511, CH5132799, PIK.75, PF.04691502, GDC.0980, CUDC.907, PI.828, AZD6482, TG.100713, BGT226, pilaralisib, PI.103, PKI.179",0.87942606879415,0.294136287716081,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.48608,1.15,0.293,189,0.796,"NMS.1286937",0.533132379645891,0.0990869322623309,FALSE
+"H1975","Pearson.est","potassium channel blocker",-0.32401,-0.871,0.58,1375,0.911,"dofetilide",0.236572006437063,0.0404816230270017,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",-0.4364,-1.25,0.183,1220,0.808,"fenofibrate, S26948, clofibrate",0.737548910269571,0.0925886392254138,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.43153,-1.22,0.19,1358,0.689,"norethindrone, dienogest, norgestrel",0.721246399047171,0.161780778092374,FALSE
+"H1975","Pearson.est","proteasome inhibitor",-0.50534,-1.46,0.0545,1389,0.462,"ONX.0914, delanzomib",1.26360349772336,0.335358024443874,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.41908,0.987,0.482,515,0.734,"brefeldin.a, cycloheximide, azomycin..2.nitroimidazole., homoharringtonine, clindamycin.phosphate, anguidine, bruceantin, emetine, thiostrepton",0.31695296176115,0.134303940083929,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.6247,1.49,0.0605,243,0.507,"NVP.TAE226, AV.412, BMS.599626, tyrphostin.A9, CP.724714",1.21824462534753,0.294992040666664,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.56058,1.32,0.148,223,0.523,"AZ.628, SB.590885, CEP.32496, regorafenib, LGX818",0.829738284605043,0.281498311132726,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.5478,1.3,0.159,653,0.509,"vandetanib, regorafenib, sorafenib, apatinib, sunitinib",0.798602875679548,0.293282217663241,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.45567,1.08,0.351,313,0.779,"CD.437, tamibarotene, adarotene",0.454692883534176,0.108462542327436,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.30906,0.716,0.829,660,0.948,"cytarabine, fludarabine.phosphate, LY2334737, triapine, clofarabine",0.0814454694497265,0.0231916626619338,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.67324,-2.01,0.0193,1288,0.0998,"SR.57227A, pardoprunox, aripiprazole",1.71444269099223,1.00086945871263,TRUE
+"H1975","Pearson.est","serotonin receptor antagonist",0.39151,0.928,0.57,267,0.747,"SB.228357, SB.200646, sertindole, SB.216641, pirenperone",0.244125144327509,0.126679398184601,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.22201,-0.619,0.917,1248,1,"lappaconite, oxcarbazepine, brivaracetam, cibenzoline",0.0376306643299789,0,FALSE
+"H1975","Pearson.est","src inhibitor",0.47974,1.14,0.313,356,0.787,"ZM.306416, saracatinib, dasatinib, bosutinib",0.504455662453552,0.104025267640935,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",0.43812,1.02,0.438,445,0.778,"lanoconazole, posaconazole, sulconazole",0.3585258894959,0.109020403010311,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.49183,1.15,0.316,461,0.796,"D.4476, SB.525334, SB.431542, repsox",0.500312917381596,0.0990869322623309,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.595,1.36,0.121,326,0.494,"carmofur, raltitrexed, trifluridine",0.91721462968355,0.306273051076353,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",-0.17217,-0.481,0.985,245,0.989,"amsacrine, idarubicin, SN.38, exatecan.mesylate, voreloxin, valrubicin, licochalcone.a, TAS.103, camptothecin, dexrazoxane, teniposide, doxorubicin, nemorubicin, beta.lapachone, topotecan, fleroxacin, mitoxantrone, genz.644282, rubitecan, daunorubicin, amonafide, irinotecan, etoposide, epirubicin, etoposide.phosphate",0.00656376950238827,0.0048037084028206,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",-0.20114,-0.559,0.958,1327,1,"docetaxel, vinblastine, paclitaxel, epothilone.d, BNC105",0.0186344909214556,0,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",0.47713,1.1,0.342,441,0.824,"NVP.TAE226, vandetanib, AV.412, hypericin, BMS.599626, tyrphostin.A9, regorafenib, CP.724714, dasatinib, aminopurvalanol.a, tivantinib, sorafenib, bafetinib",0.465973893943865,0.0840727883028842,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",0.40466,0.957,0.541,335,0.714,"XL.647, BMS.690514, ZM.306416, OSI.930, vandetanib, ENMD.2076, AEE788, regorafenib, golvatinib, PD.173074, dovitinib",0.266802734893431,0.146301788223826,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.6109,1.43,0.084,459,0.549,"tacalcitol, alfacalcidol, ercalcitriol, calcitriol, maxacalcitol",1.07572071393812,0.260427655549908,FALSE
+"H1648","Pearson.est","EGFR inhibitor",-0.8675,-2.36,0.00325,1404,0.00209,"icotinib, BIBU.1361, PD.153035, AST.1306, TAK.285, AEE788, rociletinib, vandetanib, WZ8040, CP.724714, BMS.599626, BIBX.1382, pelitinib, GW.583340, ARRY.334543, PD.168393, erlotinib, gefitinib, osimertinib, afatinib, BMS.690514, lapatinib, dacomitinib, XL.647, canertinib, tucatinib, neratinib, poziotinib, AZD8931",2.48811663902113,2.67985371388895,TRUE
+"H1648","Pearson.est","Abl kinase inhibitor",0.46859,1.11,0.335,264,0.59,"GZD824, tozasertib, ponatinib, nilotinib, bafetinib, KW.2449, flumatinib",0.474955192963155,0.229147988357856,FALSE
+"H1648","Pearson.est","acetylcholine receptor agonist",0.52918,1.26,0.182,36,0.488,"oxiracetam",0.739928612014925,0.311580177997289,FALSE
+"H1648","Pearson.est","acetylcholine receptor antagonist",0.50363,1.2,0.267,520,0.528,"iododexetimide, diphemanil, darifenacin",0.573488738635425,0.277366077466188,FALSE
+"H1648","Pearson.est","adenosine receptor antagonist",-0.48527,-1.27,0.196,1291,0.559,"theophylline, MRS.1220, CGS.15943",0.707743928643524,0.252588192113577,FALSE
+"H1648","Pearson.est","adrenergic receptor agonist",0.26433,0.634,0.903,794,0.985,"buphenine, isoetharine, oxymetazoline, norepinephrine, metaraminol, ritodrine, clenbuterol, lidamidine, isoxsuprine, midodrine",0.0443122496864942,0.00656376950238827,FALSE
+"H1648","Pearson.est","adrenergic receptor antagonist",0.37103,0.879,0.615,452,0.785,"oxprenolol, metoprolol, carvedilol, naftidrofuryl, levobunolol, atipamezole, idazoxan",0.211124884224583,0.105130343254747,FALSE
+"H1648","Pearson.est","AKT inhibitor",-0.62829,-1.65,0.0645,1247,0.323,"A.674563, GSK2110183, CCT128930, triciribine, uprosertib, GDC.0068",1.19044028536473,0.490797477668897,FALSE
+"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27322,-0.707,0.798,1360,0.955,"GW.788388, brigatinib",0.0979971086492706,0.0199966284162537,FALSE
+"H1648","Pearson.est","androgen receptor antagonist",0.51595,1.23,0.217,268,0.488,"nilutamide, bicalutamide",0.66354026615147,0.311580177997289,FALSE
+"H1648","Pearson.est","antioxidant",0.63141,1.51,0.0641,258,0.451,"trolox, benfotiamine, chlorogenic.acid",1.19314197048118,0.345823458122039,FALSE
+"H1648","Pearson.est","AP inhibitor",0.45152,1.07,0.374,239,0.593,"idronoxil, embelin",0.42712839779952,0.226945306635737,FALSE
+"H1648","Pearson.est","ATPase inhibitor",0.30413,0.731,0.807,615,0.933,"digoxin, blebbistatin...., digitoxin, ouabain, thonzonium, evodiamine, digitoxigenin",0.0931264652779296,0.0301183562535,FALSE
+"H1648","Pearson.est","Aurora kinase inhibitor",0.42414,1.02,0.446,412,0.629,"barasertib, tozasertib, AT.9283, AMG900, SNS.314, KW.2449, PF.03814735, hesperadin, barasertib.HQPA, ENMD.2076, alisertib",0.350665141287858,0.201349354554731,FALSE
+"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36159,-0.954,0.46,1248,0.974,"josamycin, tedizolid, azithromycin",0.337242168318426,0.0114410431213845,FALSE
+"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.21439,0.521,0.98,633,0.987,"novobiocin, sparfloxacin, norfloxacin, sarafloxacin",0.00877392430750515,0.00568284733036327,FALSE
+"H1648","Pearson.est","BCL inhibitor",0.48386,1.17,0.263,553,0.513,"venetoclax, TW.37, oridonin, gossypol, ABT.737",0.580044251510242,0.289882634888184,FALSE
+"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.55817,1.34,0.137,264,0.608,"GZD824, tozasertib, ponatinib, nilotinib, bafetinib, flumatinib",0.863279432843593,0.216096420727265,FALSE
+"H1648","Pearson.est","benzodiazepine receptor agonist",0.31877,0.765,0.761,656,0.926,"temazepam, indiplon, ZK.93423, eprinomectin, zaleplon, piperazine, gamma.aminobutyric.acid",0.118615343229427,0.0333890133180656,FALSE
+"H1648","Pearson.est","bromodomain inhibitor",-0.27947,-0.74,0.757,403,0.948,"bromosporine, PFI.1, I.BET.762, I.BET151, JQ1...., OTX015",0.120904120499927,0.0231916626619338,FALSE
+"H1648","Pearson.est","calcium channel blocker",-0.28169,-0.762,0.782,1325,1,"fendiline, SKF.96365",0.106793246940152,0,FALSE
+"H1648","Pearson.est","CC chemokine receptor antagonist",0.68501,1.63,0.0204,357,0.485,"UNBS.5162, navarixin, PF.04136309, SB.225002, MK.0812",1.6903698325741,0.314258261397736,FALSE
+"H1648","Pearson.est","CDK inhibitor",-0.25131,-0.64,0.893,1371,1,"BMS.387032, indirubin, AT.7519",0.0491485411114536,0,FALSE
+"H1648","Pearson.est","CHK inhibitor",-0.47606,-1.27,0.197,686,0.559,"SB.218078, PF.477736, SCH.900776, AZD7762, LY2606368, CHIR.124, LY2603618",0.705533773838407,0.252588192113577,FALSE
+"H1648","Pearson.est","cyclooxygenase inhibitor",-0.20309,-0.541,0.961,1336,0.962,"tryptanthrin, ramifenazone, FK.3311, amfenac",0.0172766123314547,0.0168249279621871,FALSE
+"H1648","Pearson.est","cytochrome P450 inhibitor",0.60897,1.45,0.0874,370,0.495,"metyrapone, morin, cobicistat, itraconazole",1.0584885673656,0.305394801066431,FALSE
+"H1648","Pearson.est","DNA alkylating agent",0.37005,0.89,0.593,135,0.784,"melphalan, carboplatin, carmustine",0.226945306635737,0.105683937315562,FALSE
+"H1648","Pearson.est","DNA inhibitor",0.41542,0.991,0.478,417,0.663,"melphalan, carboplatin, chlorambucil, carmustine, pibenzimol, bendamustine, valrubicin, teroxirone",0.320572103387881,0.178486471595227,FALSE
+"H1648","Pearson.est","DNA methyltransferase inhibitor",-0.50353,-1.3,0.161,1380,0.655,"decitabine, azacitidine, SGI.1027",0.79317412396815,0.183758700008217,FALSE
+"H1648","Pearson.est","DNA polymerase inhibitor",0.26677,0.645,0.884,495,0.993,"foscarnet, idoxuridine, trifluridine",0.0535477349869269,0.00305075150461883,FALSE
+"H1648","Pearson.est","DNA synthesis inhibitor",0.49135,1.19,0.258,385,0.511,"nelarabine, azodicarbonamide, anisomycin, floxuridine, artesunate, artemisinin, CB.10.277",0.58838029403677,0.291579099865287,FALSE
+"H1648","Pearson.est","dopamine receptor antagonist",0.27846,0.661,0.852,193,0.997,"amisulpride, raclopride, paliperidone",0.0695604052332999,0.00130484168834428,FALSE
+"H1648","Pearson.est","estrogen receptor agonist",-0.27905,-0.746,0.786,1312,0.984,"erteberel, levonorgestrel",0.104577453960592,0.00700490156865849,FALSE
+"H1648","Pearson.est","estrogen receptor antagonist",0.45424,1.1,0.367,324,0.574,"fulvestrant, danazol, toremifene",0.435333935747911,0.241088107602027,FALSE
+"H1648","Pearson.est","FGFR inhibitor",0.64732,1.54,0.0435,236,0.441,"erdafitinib, dovitinib, regorafenib, nintedanib, MK.2461, orantinib",1.36151074304536,0.355561410532161,FALSE
+"H1648","Pearson.est","FLT3 inhibitor",0.62797,1.48,0.0585,294,0.47,"dovitinib, TG.101348, tozasertib, midostaurin, ponatinib, quizartinib, sunitinib, KW.2449, lestaurtinib, gilteritinib",1.23284413391782,0.327902142064283,FALSE
+"H1648","Pearson.est","glucocorticoid receptor agonist",-0.54631,-1.45,0.0886,1137,0.466,"difluprednate, dexamethasone.acetate, halobetasol.propionate, halcinonide, desonide, flumethasone.pivalate, methylprednisolone, beclomethasone.dipropionate, ciclesonide, fluorometholone, fludroxycortide, clobetasol.propionate, betamethasone, flumethasone, triamcinolone.acetonide",1.05256627811295,0.33161408331,FALSE
+"H1648","Pearson.est","glutamate receptor antagonist",0.15631,0.369,1,741,0.999,"MTPG, ACDPP, IEM1754, diazooxonorleucine, felbamate, CPP, SIB.1757",0,0.000434511774017692,FALSE
+"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.31993,0.767,0.744,459,0.943,"tideglusib, CHIR.99021, CHIR.98014, GSK.3.inhibitor.IX",0.128427064454121,0.0254883072626717,FALSE
+"H1648","Pearson.est","growth factor receptor inhibitor",0.37789,0.9,0.588,596,0.787,"lestaurtinib, danusertib, PHA.848125, GSK1838705A, AZD3463",0.230622673923862,0.104025267640935,FALSE
+"H1648","Pearson.est","HCV inhibitor",0.49252,1.18,0.272,384,0.513,"narlaprevir, embelin, mericitabine",0.565431095965801,0.289882634888184,FALSE
+"H1648","Pearson.est","HDAC inhibitor",0.30553,0.736,0.78,740,0.946,"entinostat, resminostat, dacinostat, trichostatin.a, RG2833, R306465, nexturastat.a, belinostat, M.344, vorinostat, ACY.1215, chidamide, scriptaid, NSC.3852, panobinostat",0.10790539730952,0.0241088635982073,FALSE
+"H1648","Pearson.est","histamine receptor antagonist",0.24554,0.588,0.939,491,0.985,"pheniramine, famotidine, cimetidine, tiotidine, lafutidine, ICI.162846, epinastine, nizatidine",0.0273344077338891,0.00656376950238827,FALSE
+"H1648","Pearson.est","HMGCR inhibitor",0.88532,2.13,0.00145,6,0.000981,"mevastatin, pitavastatin, fluvastatin, atorvastatin",2.83863199776503,3.00833099262005,TRUE
+"H1648","Pearson.est","HSP inhibitor",-0.32629,-0.849,0.641,1307,0.948,"VER.49009, tanespimycin, alvespimycin, KW.2478",0.193141970481183,0.0231916626619338,FALSE
+"H1648","Pearson.est","JAK inhibitor",0.45604,1.09,0.369,263,0.575,"TG.101348, tozasertib, AT.9283, TG.101209, AZ960, lestaurtinib",0.43297363384094,0.24033215531037,FALSE
+"H1648","Pearson.est","KIT inhibitor",0.50095,1.19,0.279,529,0.511,"KI.8751, midostaurin, pazopanib, regorafenib, sunitinib, masitinib, motesanib, telatinib, sorafenib, lenvatinib",0.554395796726402,0.291579099865287,FALSE
+"H1648","Pearson.est","MDM inhibitor",0.87828,2.14,0,80,0.00196,"idasanutlin, AMG.232, nutlin.3, CGM097, serdemetan",Inf,2.70774392864352,TRUE
+"H1648","Pearson.est","MEK inhibitor",-0.33511,-0.894,0.579,1141,0.912,"PD.198306, PD.318088, PD.0325901, PD.184352, AZD8330, Ro.4987655, selumetinib, AS.703026, trametinib",0.237321436272564,0.0400051616715838,FALSE
+"H1648","Pearson.est","MET inhibitor",-0.35399,-0.934,0.517,1422,0.947,"INC.280",0.286509456906058,0.0236500209967266,FALSE
+"H1648","Pearson.est","microtubule inhibitor",0.54939,1.3,0.158,133,0.498,"vinblastine, secnidazole, vinflunine",0.801342913045577,0.302770657240282,FALSE
+"H1648","Pearson.est","mTOR inhibitor",0.22145,0.537,0.964,669,0.998,"torin.1, ku.0063794, deforolimus, LY303511, WAY.600, SB.2343, LY3023414, sirolimus, NVP.BEZ235, PKI.179, XL388, temsirolimus, AZD8055, AZD2014",0.0159229660971692,0.000869458712628891,FALSE
+"H1648","Pearson.est","NFkB pathway inhibitor",-0.2305,-0.618,0.895,331,0.98,"BAY.11.7082, bortezomib, betulinic.acid, BAY.11.7085, curcumin, parthenolide...., parthenolide, bindarit, EVP4593, tyloxapol, Ro.106.9920, IKK.2.inhibitor.V",0.048176964684088,0.00877392430750515,FALSE
+"H1648","Pearson.est","opioid receptor agonist",0.59792,1.44,0.0795,518,0.473,"cebranopadol, trimebutine, BW.180C, spiradoline, salvinorin.a",1.09963287134353,0.325138859262188,FALSE
+"H1648","Pearson.est","p38 MAPK inhibitor",-0.42596,-1.09,0.361,1323,0.879,"SB.239063, talmapimod",0.442492798094342,0.0560111249262281,FALSE
+"H1648","Pearson.est","PARP inhibitor",0.55286,1.33,0.154,433,0.591,"talazoparib, AG.14361, niraparib, PJ.34",0.812479279163537,0.228412519118745,FALSE
+"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.54535,1.31,0.153,529,0.504,"KI.8751, dovitinib, axitinib, ponatinib, pazopanib, regorafenib, sunitinib, nintedanib, orantinib, masitinib, CP.673451, SU014813, crenolanib, trapidil, motesanib, telatinib, sorafenib, lenvatinib",0.815308569182401,0.297569463554475,FALSE
+"H1648","Pearson.est","phosphatase inhibitor",0.6766,1.6,0.0322,61,0.455,"bis.maltolato.oxovanadium.IV., GSK2830371, BVT.948, sodium.stibogluconate",1.49214412830417,0.341988603342888,FALSE
+"H1648","Pearson.est","phosphodiesterase inhibitor",0.53453,1.26,0.183,33,0.488,"anagrelide, GSK256066",0.737548910269571,0.311580177997289,FALSE
+"H1648","Pearson.est","PI3K inhibitor",-0.34815,-0.928,0.521,1265,0.896,"TG.100713, PF.05212384, GDC.0980, GSK2126458, CH5132799, alpelisib, taselisib",0.283162276700476,0.0476919903378748,FALSE
+"H1648","Pearson.est","PLK inhibitor",0.57843,1.37,0.121,379,0.622,"rigosertib, volasertib, GSK461364",0.91721462968355,0.206209615309181,FALSE
+"H1648","Pearson.est","potassium channel blocker",0.52543,1.25,0.184,558,0.488,"meglitinide, dofetilide, mepivacaine, oleoylethanolamide",0.735182176990464,0.311580177997289,FALSE
+"H1648","Pearson.est","PPAR receptor agonist",0.45597,1.1,0.359,698,0.574,"clofibrate, GW.501516, fenofibrate, oleoylethanolamide, S26948, ciprofibrate",0.444905551421681,0.241088107602027,FALSE
+"H1648","Pearson.est","progesterone receptor agonist",0.55625,1.32,0.155,153,0.577,"norethindrone, danazol, tanaproget",0.809668301829709,0.238824186844269,FALSE
+"H1648","Pearson.est","proteasome inhibitor",0.54645,1.31,0.153,536,0.504,"ixazomib, MG.132, delanzomib, oprozomib, bortezomib, ONX.0914",0.815308569182401,0.297569463554475,FALSE
+"H1648","Pearson.est","protein synthesis inhibitor",0.43581,1.06,0.393,336,0.593,"brefeldin.a, mercaptopurine, cycloheximide, homoharringtonine, harringtonine, methacycline, anguidine",0.405607449624573,0.226945306635737,FALSE
+"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.73932,-1.96,0.00687,1418,0.0805,"CP.724714, BMS.599626, AV.412",2.16304326294045,1.09420411963213,TRUE
+"H1648","Pearson.est","RAF inhibitor",0.54133,1.31,0.156,640,0.504,"dabrafenib, vemurafenib, regorafenib, TAK.632, LGX818, GDC.0879, CEP.32496, sorafenib, RAF265, SB.590885, AZ.628",0.806875401645538,0.297569463554475,FALSE
+"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.38665,0.929,0.564,151,0.754,"regorafenib, sunitinib",0.248720896016658,0.122628654130226,FALSE
+"H1648","Pearson.est","retinoid receptor agonist",0.25275,0.6,0.912,137,0.994,"fenretinide",0.0400051616715838,0.00261361560268669,FALSE
+"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.66371,1.57,0.0418,443,0.437,"cladribine, pentostatin, triapine, clofarabine, fludarabine, fludarabine.phosphate, hydroxyurea, LY2334737",1.37882371822496,0.359518563029578,FALSE
+"H1648","Pearson.est","serotonin receptor agonist",0.56884,1.35,0.129,527,0.627,"NAN.190, aripiprazole, SR.57227A, ipsapirone",0.889410289700751,0.202732459169284,FALSE
+"H1648","Pearson.est","serotonin receptor antagonist",0.51875,1.24,0.221,262,0.487,"lerisetron, SB.200646, aripiprazole, paliperidone, pirenperone",0.655607726314889,0.312471038785366,FALSE
+"H1648","Pearson.est","sodium channel blocker",-0.20939,-0.546,0.969,1286,0.997,"A.803467, lappaconite, brivaracetam",0.0136762229492347,0.00130484168834428,FALSE
+"H1648","Pearson.est","src inhibitor",-0.58654,-1.55,0.0629,1332,0.389,"dasatinib, bosutinib, ZM.306416, saracatinib",1.20134935455473,0.410050398674292,FALSE
+"H1648","Pearson.est","sterol demethylase inhibitor",0.5386,1.28,0.181,347,0.49,"ketoconazole, posaconazole, chlormidazole, lanoconazole",0.742321425130815,0.309803919971486,FALSE
+"H1648","Pearson.est","TGF beta receptor inhibitor",-0.38776,-1.06,0.377,1402,0.866,"repsox",0.423658649794207,0.0624821079826534,FALSE
+"H1648","Pearson.est","thymidylate synthase inhibitor",0.42473,1.02,0.444,523,0.629,"ftorafur, trifluridine, doxifluridine, raltitrexed",0.35261702988538,0.201349354554731,FALSE
+"H1648","Pearson.est","topoisomerase inhibitor",0.53522,1.28,0.167,415,0.49,"nemorubicin, etoposide.phosphate, topotecan, teniposide, daunorubicin, voreloxin, doxorubicin, amsacrine, epirubicin, rubitecan, idarubicin, TAS.103, valrubicin, amonafide, etoposide",0.777283528852417,0.309803919971486,FALSE
+"H1648","Pearson.est","tubulin polymerization inhibitor",0.492,1.16,0.29,511,0.515,"verubulin, vinblastine, BNC105, taltobulin, combretastatin.A.4, vindesine, CYT.997, vincristine, plinabulin, KX2.391, fosbretabulin, vinorelbine, podophyllotoxin, dolastatin.10",0.537602002101044,0.288192770958809,FALSE
+"H1648","Pearson.est","tyrosine kinase inhibitor",-0.36687,-0.965,0.48,1415,1,"vandetanib, CP.724714, BMS.599626, AV.412",0.318758762624413,0,FALSE
+"H1648","Pearson.est","VEGFR inhibitor",-0.30751,-0.794,0.652,1411,1,"AEE788, vandetanib, ZM.306416, BMS.690514, XL.647",0.18575240426808,0,FALSE
+"H1648","Pearson.est","vitamin D receptor agonist",-0.85631,-2.28,0,1299,0.00627,"ercalcitriol, paricalcitol, tacalcitol, calcitriol, maxacalcitol",Inf,2.20273245916928,TRUE
+"H2126","Pearson.est","EGFR inhibitor",-0.83003,-2.18,0,1371,0.0166,"rociletinib, AST.1306, vandetanib, BIBU.1361, afatinib, WZ8040, PD.153035, TAK.285, erlotinib, AEE788, CUDC.101, dacomitinib, ARRY.334543, BMS.599626, BIBX.1382, gefitinib, canertinib, osimertinib, CP.724714, GW.583340, XL.647, poziotinib, PD.168393, BMS.690514, lapatinib, neratinib, AZD8931, tucatinib",Inf,1.77989191195995,TRUE
+"H2126","Pearson.est","Abl kinase inhibitor",0.48701,1.19,0.256,94,0.593,"ponatinib, GZD824, tozasertib, KW.2449",0.59176003468815,0.226945306635737,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",0.31132,0.769,0.766,79,0.882,"oxiracetam",0.115771230367396,0.0545314148681803,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",0.23508,0.583,0.946,216,0.986,"iododexetimide",0.0241088635982073,0.0061230850587888,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.74087,-1.96,0.0119,1390,0.0524,"SCH.58261, MRS.1220, CGS.15943",1.92445303860747,1.28066871301627,TRUE
+"H2126","Pearson.est","adrenergic receptor agonist",0.28732,0.682,0.848,538,0.943,"midodrine, lidamidine, buphenine, clenbuterol, oxymetazoline, terbutaline, ritodrine",0.0716041477432862,0.0254883072626717,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",0.22516,0.549,0.946,499,0.991,"oxprenolol, idazoxan, carvedilol, metoprolol, levobunolol, naftidrofuryl, atipamezole",0.0241088635982073,0.00392634551472468,FALSE
+"H2126","Pearson.est","AKT inhibitor",-0.72093,-1.91,0.00893,1295,0.0523,"triciribine, A.674563, CCT128930, uprosertib, GSK2110183, GDC.0068",2.04914854111145,1.28149831113273,TRUE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.41451,0.994,0.475,346,0.784,"lorlatinib, DMH1, AZD3463, alectinib",0.323306390375133,0.105683937315562,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",0.37416,0.909,0.565,505,0.86,"nilutamide, bicalutamide, cyproterone.acetate",0.247951552180562,0.0655015487564323,FALSE
+"H2126","Pearson.est","antioxidant",0.50686,1.23,0.224,594,0.584,"mesna, trolox, benfotiamine, chlorogenic.acid",0.649751981665837,0.233587152887601,FALSE
+"H2126","Pearson.est","AP inhibitor",0.33481,0.811,0.692,593,0.89,"idronoxil, embelin, GDC.0152, LCL.161, birinapant",0.159893905543242,0.0506099933550872,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.41785,1.01,0.454,310,0.775,"ouabain, blebbistatin...., digitoxin, digoxin, thonzonium, digitoxigenin",0.342944147142896,0.11069829749369,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.48142,1.14,0.331,348,0.625,"barasertib, tozasertib, KW.2449, AT.9283, AMG900, SNS.314, PF.03814735, hesperadin, GSK1070916, barasertib.HQPA, alisertib, ENMD.2076",0.480172006224281,0.204119982655925,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.25396,0.611,0.911,153,0.981,"valnemulin",0.0404816230270017,0.0083309926200515,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.38054,0.931,0.525,136,0.862,"sparfloxacin, novobiocin",0.279840696594043,0.0644927341752872,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.39995,0.984,0.492,484,0.78,"venetoclax, obatoclax, TW.37, ABT.737, gossypol",0.30803489723264,0.10790539730952,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.54689,1.32,0.162,397,0.602,"ponatinib, GZD824, tozasertib, nilotinib, flumatinib, bafetinib",0.790484985457369,0.220403508742175,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",0.21028,0.513,0.972,742,0.991,"temazepam, piperazine, indiplon, eprinomectin, zaleplon, gamma.aminobutyric.acid, ivermectin, ZK.93423, CGS.20625",0.0123337350737254,0.00392634551472468,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",-0.8054,-2.13,0,1285,0.0177,"I.BET151, OTX015, JQ1....",Inf,1.75202673363819,TRUE
+"H2126","Pearson.est","calcium channel blocker",-0.36069,-0.952,0.451,1224,0.774,"SKF.96365, SR.33805, fendiline",0.345823458122039,0.111259039317107,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.68157,1.68,0.0214,377,0.319,"UNBS.5162, SB.225002, navarixin, PF.04136309, MK.0812",1.66958622665081,0.496209316942819,FALSE
+"H2126","Pearson.est","CDK inhibitor",-0.24804,-0.666,0.852,1427,0.938,"arcyriaflavin.a, indirubin",0.0695604052332999,0.0277971616209356,FALSE
+"H2126","Pearson.est","CHK inhibitor",0.4989,1.24,0.215,466,0.617,"SCH.900776, LY2606368, PF.477736, SB.218078",0.667561540084395,0.209714835966758,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.17321,-0.466,0.997,1067,0.99,"metoxibutropate, meloxicam, sulfasalazine, AM.404, ramifenazone, aspirin, FK.3311, amfenac, tryptanthrin",0.00130484168834428,0.00436480540245009,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",0.6974,1.72,0.0139,114,0.444,"metyrapone, itraconazole, morin",1.8569851997459,0.35261702988538,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.50166,1.23,0.256,328,0.584,"melphalan, carmustine, carboplatin, temozolomide, estramustine, streptozotocin",0.59176003468815,0.233587152887601,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.3449,0.831,0.68,257,0.877,"melphalan, carmustine, chlorambucil, carboplatin",0.167491087293764,0.0570004066339595,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",-0.31449,-0.823,0.644,1256,0.822,"azacitidine, SGI.1027",0.191114132640188,0.0851281824599496,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",0.4831,1.17,0.277,497,0.586,"trifluridine, idoxuridine, adefovir.dipivoxil, foscarnet",0.557520230935551,0.232102383981909,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",0.41355,1.01,0.439,644,0.775,"nelarabine, anisomycin, floxuridine, cyclocytidine, artesunate, azodicarbonamide, artemisinin, capecitabine, CB.10.277",0.357535479757879,0.11069829749369,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",0.31935,0.793,0.741,160,0.882,"raclopride, paliperidone, amisulpride, isofloxythepin",0.130181792020672,0.0545314148681803,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",0.2636,0.634,0.888,524,0.977,"estrone, PPT, estradiol",0.051587034221399,0.0101054362812269,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",0.34524,0.842,0.642,476,0.879,"toremifene, fulvestrant, raloxifene, danazol",0.192464971931147,0.0560111249262281,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.53259,1.28,0.196,247,0.59,"erdafitinib, dovitinib, MK.2461, regorafenib",0.707743928643524,0.229147988357856,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.57093,1.43,0.114,348,0.491,"ponatinib, gilteritinib, tozasertib, dovitinib, KW.2449, lestaurtinib, sunitinib, midostaurin, tyrphostin.AG.1296, quizartinib, ENMD.2076",0.943095148663527,0.308918507877032,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",-0.30724,-0.808,0.679,1050,0.806,"deflazacort, rimexolone, halobetasol.propionate, betamethasone, beclomethasone.dipropionate, difluprednate, fludroxycortide, halcinonide, flumethasone, methylprednisolone, triamcinolone.acetonide, clobetasol.propionate",0.168130225719498,0.0936649581949093,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.36744,-0.977,0.476,1160,0.779,"CPP, ACDPP, latrepirdine, LY456236, tiletamine, CGP.37849",0.322393047279507,0.108462542327436,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.32802,-0.88,0.538,1431,0.807,"indirubin",0.269217724333611,0.0931264652779296,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.47401,1.13,0.324,261,0.623,"PHA.848125, GSK1838705A, lestaurtinib, AZD3463",0.489454989793388,0.20551195334083,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.48922,1.2,0.267,386,0.596,"narlaprevir, embelin, mericitabine",0.573488738635425,0.224753740259764,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.63626,-1.73,0.0338,1080,0.119,"vorinostat, R306465, panobinostat, scriptaid, AR.42, tacedinaline, romidepsin, PCI.24781, M.344, JNJ.26481585, givinostat, mocetinostat, SB.939, pyroxamide",1.47108329972235,0.924453038607469,TRUE
+"H2126","Pearson.est","histamine receptor antagonist",0.29944,0.719,0.82,302,0.915,"cimetidine, pheniramine, astemizole, tiotidine, famotidine",0.0861861476162833,0.0385789059335517,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",0.91756,2.25,0,14,0,"fluvastatin, atorvastatin, mevastatin, pitavastatin",Inf,Inf,TRUE
+"H2126","Pearson.est","HSP inhibitor",0.45381,1.11,0.361,326,0.642,"SNX.2112, NVP.AUY922, ganetespib, NMS.E973, BIIB021, SNX.5422, PU.H71",0.442492798094342,0.192464971931147,FALSE
+"H2126","Pearson.est","JAK inhibitor",0.35905,0.864,0.633,503,0.902,"tozasertib, AT.9283, lestaurtinib, AZ960, PRT062070, TG.101209, TG.101348",0.198596289982645,0.0447934624580583,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.49951,1.21,0.256,634,0.602,"KI.8751, sunitinib, midostaurin, motesanib, regorafenib, cediranib, pazopanib, lenvatinib, telatinib, dasatinib, sorafenib, OSI.930, masitinib",0.59176003468815,0.220403508742175,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.31739,-0.829,0.669,1421,0.856,"RITA",0.174573882232177,0.0675262353228468,FALSE
+"H2126","Pearson.est","MEK inhibitor",0.32807,0.808,0.671,755,0.876,"PD.318088, U.0126, cobimetinib, AZD8330, PD.0325901, refametinib, TAK.733, Ro.4987655, AS.703026, arctigenin, MEK162, BIX.02188",0.173277479831008,0.0574958938319193,FALSE
+"H2126","Pearson.est","MET inhibitor",-0.4006,-1.03,0.415,1387,0.727,"NVP.BVU972, INC.280",0.381951903287907,0.138465589140962,FALSE
+"H2126","Pearson.est","microtubule inhibitor",0.67524,1.66,0.0368,173,0.208,"vinblastine, vinflunine, podophyllotoxin, cabazitaxel, secnidazole",1.43415218132648,0.681936665037238,TRUE
+"H2126","Pearson.est","mTOR inhibitor",-0.33124,-0.886,0.537,1111,0.847,"XL388, torin.2, voxtalisib, palomid.529, PP242, WYE.125132, PF.05212384, GDC.0980, PI.103, GSK2126458",0.270025714300444,0.0721165896692931,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.18063,-0.478,0.989,1203,1,"Ro.106.9920, EVP4593, tyloxapol",0.0048037084028206,0,FALSE
+"H2126","Pearson.est","opioid receptor agonist",0.56838,1.37,0.131,460,0.52,"spiradoline, cebranopadol, trimebutine, BW.180C",0.882728704344236,0.283996656365201,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",-0.4372,-1.17,0.273,630,0.711,"skepinone.l, TAK.715, CMPD.1, SB.242235, VX.702, talmapimod, SB.239063",0.563837352959244,0.148130399270234,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.5628,1.41,0.102,275,0.5,"talazoparib, niraparib, olaparib",0.991399828238082,0.301029995663981,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.52686,1.27,0.207,548,0.581,"ponatinib, KI.8751, SU014813, axitinib, dovitinib, CP.673451, sunitinib, motesanib, regorafenib, pazopanib, lenvatinib, telatinib, nintedanib, crenolanib, dasatinib, sorafenib",0.684029654543082,0.235823867609669,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.56742,1.39,0.122,97,0.509,"bis.maltolato.oxovanadium.IV., BVT.948, sodium.stibogluconate, GSK2830371",0.913640169325252,0.293282217663241,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",0.40722,1.01,0.462,250,0.775,"anagrelide, GSK256066, YM.976",0.335358024443874,0.11069829749369,FALSE
+"H2126","Pearson.est","PI3K inhibitor",-0.44974,-1.2,0.243,1207,0.732,"CUDC.907, PI3K.IN.2, PI.828, PF.05212384, GDC.0980, PI.103, GSK2126458, CH5132799, alpelisib, taselisib",0.614393726401688,0.135488918941608,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.59805,1.46,0.0655,512,0.464,"rigosertib, GSK461364, volasertib, GW.843682X, HMN.214, BI.2536",1.18375870000822,0.333482019445119,FALSE
+"H2126","Pearson.est","potassium channel blocker",0.30974,0.742,0.793,609,0.901,"dofetilide, mepivacaine, meglitinide",0.100726812682396,0.045275209020937,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",0.3599,0.856,0.646,140,0.895,"fenofibrate",0.189767482004916,0.048176964684088,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",0.3669,0.868,0.626,476,0.916,"norethindrone, tanaproget, danazol",0.20342566678957,0.0381045263321496,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.68299,1.7,0.0141,294,0.357,"ixazomib, bortezomib, delanzomib, MG.132, carfilzomib",1.85078088734462,0.447331783887807,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.49112,1.18,0.264,205,0.589,"brefeldin.a, mercaptopurine, cycloheximide, methacycline, homoharringtonine",0.578396073130169,0.229884705212898,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.75244,-1.93,0.00592,1249,0.0545,"tyrphostin.A9, mubritinib, AV.412, BMS.599626, CP.724714",2.22767829327708,1.26360349772336,TRUE
+"H2126","Pearson.est","RAF inhibitor",0.66605,1.58,0.043,247,0.281,"dabrafenib, vemurafenib, RAF265, GDC.0879, LGX818, AZ.628, regorafenib",1.36653154442041,0.55129368009492,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.31953,0.775,0.739,247,0.89,"sunitinib, regorafenib",0.131355561605174,0.0506099933550872,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.3507,0.851,0.645,234,0.884,"adarotene, tamibarotene",0.190440285364732,0.0535477349869269,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.53448,1.29,0.185,428,0.597,"cladribine, clofarabine, triapine, fludarabine.phosphate, LY2334737, pentostatin, gemcitabine",0.732828271596986,0.224025668870631,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",0.67564,1.67,0.0259,267,0.272,"aripiprazole, NAN.190, ipsapirone, SR.57227A",1.58670023591875,0.565431095965801,FALSE
+"H2126","Pearson.est","serotonin receptor antagonist",0.37798,0.916,0.567,119,0.867,"aripiprazole, lerisetron, paliperidone",0.246416941107093,0.0619809025237897,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.18867,0.455,0.994,516,0.991,"quinidine, mexiletine, benzocaine, mepivacaine",0.00261361560268669,0.00392634551472468,FALSE
+"H2126","Pearson.est","src inhibitor",-0.39411,-1.05,0.361,1411,0.748,"ZM.306416, saracatinib",0.442492798094342,0.126098402135539,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.53761,1.29,0.18,571,0.597,"ketoconazole, posaconazole, lanoconazole, terconazole, chlormidazole",0.744727494896694,0.224025668870631,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",-0.41401,-1.1,0.341,597,0.71,"D.4476, LY2109761, adaprev, SB.525334, SB.431542, repsox",0.467245621007502,0.148741651280925,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.67145,1.63,0.0316,338,0.227,"raltitrexed, trifluridine, carmofur, ftorafur",1.5003129173816,0.643974142806877,TRUE
+"H2126","Pearson.est","topoisomerase inhibitor",0.62204,1.49,0.089,286,0.434,"topotecan, etoposide.phosphate, teniposide, rubitecan, daunorubicin, nemorubicin, irinotecan, doxorubicin, voreloxin, SN.38, TAS.103, etoposide, idarubicin, amsacrine, dexrazoxane",1.05060999335509,0.362510270487489,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.69618,1.66,0.0235,305,0.208,"verubulin, vinblastine, BNC105, taltobulin, vindesine, podophyllotoxin, CYT.997, docetaxel, vincristine, dolastatin.10, combretastatin.A.4, plinabulin, paclitaxel, fosbretabulin, ABT.751, vinorelbine, KX2.391, epothilone.b, indibulin",1.62893213772826,0.681936665037238,TRUE
+"H2126","Pearson.est","tyrosine kinase inhibitor",-0.41526,-1.13,0.278,1320,0.716,"GTP.14564, mubritinib, vandetanib, AV.412, BMS.599626, CP.724714",0.555955204081924,0.145086977692144,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",-0.27477,-0.746,0.796,1382,0.867,"vandetanib, semaxanib, ZM.306416, AEE788, XL.647, BMS.690514",0.0990869322623309,0.0619809025237897,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.82106,-2.23,0,1345,0.0182,"ercalcitriol, paricalcitol, calcitriol, tacalcitol, maxacalcitol",Inf,1.73992861201493,TRUE
+"H520","Pearson.est","EGFR inhibitor",0.72338,1.79,0.0174,130,0.191,"poziotinib, PD.153035, vandetanib, icotinib, erlotinib, pelitinib, XL.647, gefitinib, BIBU.1361, afatinib, dacomitinib, osimertinib, AZD8931, canertinib, lapatinib, AST.1306, neratinib, BMS.599626, PD.168393",1.7594507517174,0.718966632752272,TRUE
+"H520","Pearson.est","Abl kinase inhibitor",0.6975,1.75,0.0153,321,0.197,"dasatinib, bosutinib, ZM.306416, GZD824, metatinib, ponatinib, nilotinib",1.8153085691824,0.705533773838407,TRUE
+"H520","Pearson.est","acetylcholine receptor agonist",0.38711,0.955,0.522,201,0.98,"nicotine, pilocarpine",0.282329496997738,0.00877392430750515,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",-0.38687,-1.01,0.391,1404,0.993,"diphemanil",0.407823242604133,0.00305075150461883,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",0.38874,0.962,0.509,292,1,"PSB.1115, CGS.15943",0.293282217663241,0,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.46375,1.14,0.312,273,0.728,"ritodrine, isoxsuprine, oxymetazoline, buphenine, epinephrine",0.505845405981557,0.137868620686963,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",-0.23295,-0.62,0.907,1066,1,"carvedilol, practolol, propranolol, metoprolol, dihydroergocristine, pindolol",0.0423927129399047,0,FALSE
+"H520","Pearson.est","AKT inhibitor",-0.27207,-0.699,0.802,1177,1,"GSK2110183, ONC201, GDC.0068, A.674563",0.0958256317158365,0,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.2398,0.598,0.917,149,0.985,"lorlatinib, GW.788388",0.0376306643299789,0.00656376950238827,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.29131,0.721,0.823,470,0.965,"RU.58841, nilutamide, bicalutamide",0.0846001647877302,0.0154726866562074,FALSE
+"H520","Pearson.est","antioxidant",0.54097,1.32,0.172,309,0.637,"mesna, chlorogenic.acid",0.764471553092451,0.19586056766465,FALSE
+"H520","Pearson.est","AP inhibitor",0.6253,1.59,0.0516,286,0.311,"birinapant, GDC.0152, LCL.161, embelin",1.28735029837279,0.507239610973163,FALSE
+"H520","Pearson.est","ATPase inhibitor",-0.44657,-1.16,0.287,1201,0.751,"omeprazole, digoxin, evodiamine, rabeprazole, oligomycin.a",0.542118103266008,0.124360062995832,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.65043,-1.67,0.0408,1202,0.429,"PF.03814735, danusertib, AT.9283, SNS.314, PHA.680632, AMG900, aurora.a.inhibitor.i, MK.8745, TAK.901, CCT137690, barasertib.HQPA, barasertib, ZM.447439",1.38933983691012,0.367542707815276,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.38886,0.948,0.496,48,0.956,"tedizolid",0.304518323509803,0.0195421077238999,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.37796,0.939,0.506,14,0.937,"finafloxacin",0.295849483160201,0.0282604091122217,FALSE
+"H520","Pearson.est","BCL inhibitor",-0.37735,-0.965,0.437,1126,0.991,"navitoclax, TW.37, HA14.1, ABT.737, oridonin",0.359518563029578,0.00392634551472468,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.70004,1.74,0.0216,321,0.169,"dasatinib, bosutinib, GZD824, metatinib, ponatinib, nilotinib",1.66554624884907,0.772113295386326,TRUE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.31482,0.782,0.715,329,0.983,"lorazepam, piperazine, eprinomectin, CGS.20625",0.145693958198919,0.00744648216786438,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.72072,-1.92,0.00771,1120,0.35,"bromosporine, I.BET.762, PFI.1, I.BET151, OTX015",2.11294562194904,0.455931955649724,FALSE
+"H520","Pearson.est","calcium channel blocker",0.38857,0.964,0.495,278,1,"SKF.96365, efonidipine.monoethanolate, cinnarazine",0.305394801066431,0,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",0.49066,1.21,0.243,132,0.746,"navarixin, ZK811752",0.614393726401688,0.127261172527331,FALSE
+"H520","Pearson.est","CDK inhibitor",0.21788,0.544,0.949,511,0.956,"AZD5438, alvocidib, palbociclib, kenpaullone, JNJ.7706621, ribociclib, aminopurvalanol.a, AT.7519, PHA.848125, P276.00",0.0227337875727074,0.0195421077238999,FALSE
+"H520","Pearson.est","CHK inhibitor",-0.62331,-1.64,0.0644,1318,0.329,"SB.218078, PF.477736",1.19111413264019,0.482804102050026,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",-0.26361,-0.694,0.798,1342,1,"AM.404, sulfasalazine, naproxen",0.0979971086492706,0,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.62174,1.51,0.0701,268,0.423,"morin, metyrapone, itraconazole",1.15428198203334,0.373659632624958,FALSE
+"H520","Pearson.est","DNA alkylating agent",-0.36093,-0.94,0.498,1273,0.903,"melphalan, satraplatin, dianhydrogalactitol, mitomycin.c",0.302770657240282,0.0443122496864942,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.36156,-0.984,0.462,1166,1,"primaquine, tirapazamine, melphalan, bendamustine, pibenzimol, chlorambucil, valrubicin, mechlorethamine",0.335358024443874,0,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.28711,-0.775,0.728,993,1,"fdcyd, disulfiram, SGI.1027",0.137868620686963,0,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",0.25074,0.622,0.886,304,1,"foscarnet, adefovir.dipivoxil",0.0525662781129492,0,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.31062,-0.811,0.664,1237,1,"estramustine.phosphate, artemisinin, azodicarbonamide, mitomycin.c",0.177831920631982,0,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",0.45375,1.14,0.315,399,0.728,"clebopride, acetophenazine, oxiperomide, isofloxythepin, amisulpride, domperidone, piperacetazine, UH.232....",0.501689446210399,0.137868620686963,FALSE
+"H520","Pearson.est","estrogen receptor agonist",0.23476,0.579,0.927,463,0.978,"erteberel, PPT, estrone, ethinyl.estradiol",0.0329202658555029,0.00966114521239857,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",0.36681,0.909,0.542,221,0.896,"raloxifene, clomifene",0.266000713461613,0.0476919903378748,FALSE
+"H520","Pearson.est","FGFR inhibitor",-0.53967,-1.42,0.118,1255,0.521,"dovitinib, regorafenib, erdafitinib, lenvatinib, nintedanib",0.928117992693875,0.283162276700476,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.23279,-0.612,0.901,913,1,"lestaurtinib, pacritinib, tozasertib, tyrphostin.AG.1296, midostaurin, quizartinib, TG.02, ENMD.2076, sorafenib, dovitinib, TG.101348",0.045275209020937,0,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",0.52123,1.31,0.169,259,0.609,"hydrocortisone, fluocinolone.acetonide, ciclesonide, dexamethasone.acetate, flumethasone.pivalate, triamcinolone.acetonide, halobetasol.propionate, prednisolone.acetate, desonide",0.772113295386326,0.215382707367125,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",0.28854,0.722,0.799,312,0.991,"SIB.1757, diazooxonorleucine, MTPG, latrepirdine",0.0974532206860086,0.00392634551472468,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.36965,0.931,0.548,356,0.885,"LY2090314, tideglusib, kenpaullone, TWS.119",0.261219441515631,0.0530567293021746,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",0.36099,0.869,0.607,53,0.913,"GSK1904529A",0.216811308924742,0.039529222465701,FALSE
+"H520","Pearson.est","HCV inhibitor",0.37946,0.932,0.517,341,0.917,"PSI.7976, embelin, daclatasvir",0.286509456906058,0.0376306643299789,FALSE
+"H520","Pearson.est","HDAC inhibitor",-0.57682,-1.56,0.0765,1052,0.347,"belinostat, nexturastat.a, entinostat, mocetinostat, trichostatin.a, dacinostat, PCI.24781, NSC.3852, RGFP966, ACY.1215, givinostat, SB.939, R306465, vorinostat, resminostat, chidamide, pyroxamide, scriptaid, M.344",1.11633856484638,0.459670525209126,FALSE
+"H520","Pearson.est","histamine receptor antagonist",0.28328,0.726,0.776,426,1,"astemizole, ranitidine, terfenadine, zolantidine, levocetirizine, tecastemizole, cimetidine",0.110138278741812,0,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.53804,1.34,0.159,466,0.708,"lovastatin, fluvastatin, pitavastatin, simvastatin",0.798602875679548,0.149966742310231,FALSE
+"H520","Pearson.est","HSP inhibitor",-0.33422,-0.893,0.547,1439,0.965,"NMS.E973",0.262012673666569,0.0154726866562074,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.21345,-0.575,0.954,1167,0.968,"PRT062070, LY2784544, AT.9283, ruxolitinib, TG.101348",0.0204516252959049,0.0141246426916063,FALSE
+"H520","Pearson.est","KIT inhibitor",0.29841,0.734,0.809,1,1,"dasatinib",0.0920514783877277,0,FALSE
+"H520","Pearson.est","MDM inhibitor",0.47695,1.19,0.267,332,0.744,"idasanutlin, nutlin.3",0.573488738635425,0.128427064454121,FALSE
+"H520","Pearson.est","MEK inhibitor",0.79814,2.02,0.00514,44,0.0597,"TAK.733, AZD8330, trametinib, PD.0325901, cobimetinib, Ro.4987655, refametinib, AS.703026, selumetinib, PD.318088, MEK162",2.28903688100472,1.22402566887063,TRUE
+"H520","Pearson.est","MET inhibitor",-0.28754,-0.741,0.802,1082,1,"NVP.BVU972, INC.280, AMG458",0.0958256317158365,0,FALSE
+"H520","Pearson.est","microtubule inhibitor",-0.39052,-1.02,0.404,1237,1,"estramustine.phosphate, vinflunine, colchicine",0.393618634889395,0,FALSE
+"H520","Pearson.est","mTOR inhibitor",0.54424,1.35,0.162,494,0.757,"WAY.600, torin.1, WYE.354, OSI.027, LY303511, XL388, PP242, GSK2126458, AZD8055, SB.2343, PF.04691502, AZD2014, MLN0128, voxtalisib, LY3023414, ku.0063794, NVP.BEZ235, temsirolimus",0.790484985457369,0.120904120499927,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",-0.23904,-0.612,0.923,1423,1,"BAY.11.7082",0.0347982989740879,0,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.52359,1.33,0.155,288,0.666,"ADL5859, trimebutine, BW.180C",0.809668301829709,0.176525770829699,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",0.2219,0.557,0.939,425,0.97,"TAK.715, VX.702",0.0273344077338891,0.0132282657337552,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.65403,-1.69,0.02,1296,0.514,"PJ.34, olaparib, AZD2461, niraparib, talazoparib",1.69897000433602,0.289036881004724,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.31053,-0.814,0.688,1089,1,"motesanib, sorafenib, trapidil, masitinib, axitinib, dovitinib, regorafenib, linifanib, lenvatinib, pazopanib, nintedanib",0.162411561764489,0,FALSE
+"H520","Pearson.est","phosphatase inhibitor",-0.31279,-0.8,0.668,1034,1,"menadione, AS.1949490, mycophenolate.mofetil, CID.5458317",0.175223537524454,0,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",-0.21295,-0.555,0.956,1373,0.955,"enoximone",0.0195421077238999,0.0199966284162537,FALSE
+"H520","Pearson.est","PI3K inhibitor",0.3208,0.806,0.689,480,1,"TG.100713, LY303511, AZD6482, GSK2126458, SB.2343, buparlisib, PF.04691502, GDC.0941, voxtalisib, LY3023414, NVP.BEZ235, PIK.75",0.161780778092374,0,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.70099,-1.82,0.0217,1189,0.378,"HMN.214, BI.2536, NMS.1286937, volasertib",1.66354026615147,0.422508200162775,FALSE
+"H520","Pearson.est","potassium channel blocker",-0.2982,-0.78,0.714,430,1,"oleoylethanolamide, mepivacaine, meglitinide, ML133, ibutilide, dofetilide",0.146301788223826,0,FALSE
+"H520","Pearson.est","PPAR receptor agonist",-0.51085,-1.35,0.153,1170,0.536,"pterostilbene, clofibrate, ciprofibrate, GW.501516",0.815308569182401,0.27083521030723,FALSE
+"H520","Pearson.est","progesterone receptor agonist",-0.23141,-0.609,0.894,333,0.993,"melengestrol.acetate, nomegestrol.acetate, levonorgestrel, norethindrone, dienogest, tanaproget, norethindrone.acetate, norgestrel, danazol",0.0486624812040823,0.00305075150461883,FALSE
+"H520","Pearson.est","proteasome inhibitor",-0.26018,-0.677,0.848,1096,1,"oprozomib, delanzomib, MG.132",0.0716041477432862,0,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.3581,-0.951,0.483,1246,0.971,"azomycin..2.nitroimidazole., harringtonine, bruceantin, homoharringtonine, clofoctol, anguidine",0.316052869248488,0.0127807700919951,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",0.27985,0.689,0.824,487,0.984,"BMS.599626, PP.121, AV.412, NVP.TAE226",0.0840727883028842,0.00700490156865849,FALSE
+"H520","Pearson.est","RAF inhibitor",0.43296,1.09,0.365,305,0.795,"LGX818, AZ.628, CEP.32496, dabrafenib, vemurafenib, SB.590885",0.437707135543525,0.0996328713435297,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",0.52403,1.3,0.188,17,0.584,"vandetanib",0.72584215073632,0.233587152887601,FALSE
+"H520","Pearson.est","retinoid receptor agonist",-0.49046,-1.25,0.231,1216,0.669,"adarotene, adapalene, bexarotene, fenretinide",0.636388020107856,0.174573882232177,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.60728,-1.6,0.061,1025,0.339,"gemcitabine, cladribine, fludarabine, clofarabine, hydroxyurea, cytarabine, pentostatin",1.21467016498923,0.469800301796918,FALSE
+"H520","Pearson.est","serotonin receptor agonist",-0.52589,-1.39,0.145,1361,0.517,"zolmitriptan, aripiprazole",0.838631997765025,0.286509456906058,FALSE
+"H520","Pearson.est","serotonin receptor antagonist",-0.35474,-0.949,0.506,1447,0.927,"aripiprazole",0.295849483160201,0.0329202658555029,FALSE
+"H520","Pearson.est","sodium channel blocker",-0.22785,-0.604,0.908,1203,0.97,"brivaracetam, triamterene, oxcarbazepine, cibenzoline",0.0419141514789149,0.0132282657337552,FALSE
+"H520","Pearson.est","src inhibitor",0.6866,1.69,0.0371,83,0.202,"dasatinib, PP.2, saracatinib, bosutinib, ZM.306416",1.43062609038495,0.694648630553376,TRUE
+"H520","Pearson.est","sterol demethylase inhibitor",0.36398,0.906,0.552,169,0.871,"sulconazole, terconazole",0.258060922270801,0.0599818449923368,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",0.45947,1.14,0.297,92,0.728,"repsox",0.527243550682788,0.137868620686963,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",0.73357,1.8,0.00984,313,0.269,"carmofur, capecitabine, ftorafur, raltitrexed",2.00700490156866,0.570247719997592,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",-0.62958,-1.65,0.0622,1121,0.376,"amsacrine, irinotecan, genz.644282, dexrazoxane, teniposide, voreloxin, doxorubicin, daunorubicin, mitoxantrone, topotecan, valrubicin, etoposide, amonafide, nemorubicin, etoposide.phosphate, epirubicin",1.20620961530918,0.424812155072339,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.4619,-1.19,0.281,945,0.74,"epothilone.d, dolastatin.10, mebendazole, vindesine, BNC105, vinorelbine, verubulin, fosbretabulin, vincristine, CYT.997, flubendazole, ABT.751, albendazole, combretastatin.A.4, fenbendazole, taltobulin, KX2.391",0.55129368009492,0.130768280269024,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",0.32734,0.803,0.69,126,0.975,"dasatinib, vandetanib, BMS.599626",0.161150909262745,0.0109953843014632,FALSE
+"H520","Pearson.est","VEGFR inhibitor",0.24002,0.599,0.934,178,1,"vandetanib, XL.647, ZM.306416, SU014813, BMS.690514, lucitanib",0.0296531237699066,0,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",0.26865,0.688,0.813,310,0.96,"ercalcitriol, tacalcitol",0.0899094544059319,0.0177287669604316,FALSE
+"H460","Pearson.est","EGFR inhibitor",0.18479,0.566,0.918,1188,1,"tucatinib, BMS.690514, canertinib, AZD8931, tyrphostin.AG.494, lapatinib, FERb.033, neratinib, PD.168393, brigatinib, XL.647, poziotinib, icotinib, ARRY.334543, GW.583340, salvianolic.acid.B, osimertinib, gefitinib, erlotinib, dacomitinib, TAK.285, vandetanib, BIBX.1382, WZ8040, CP.724714, afatinib, WZ.3146, rociletinib, AEE788, tyrphostin.AG.1478, CGP.52411, dovitinib, pelitinib, OSI.420, PD.153035, BMS.599626, CUDC.101, BIBU.1361, CNX.2006, WZ.4002, AST.1306",0.0371573187987575,0,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.41326,-0.993,0.482,792,0.942,"ponatinib, flumatinib, GZD824, metatinib, tozasertib, nilotinib, KW.2449, bosutinib",0.31695296176115,0.0259490972071227,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.32193,-0.785,0.747,755,1,"tremorine, nicotine, pilocarpine, oxiracetam",0.126679398184601,0,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.4896,1.51,0.065,742,0.561,"diphemanil, darifenacin, iododexetimide, dicycloverine, hyoscyamine, methscopolamine",1.18708664335714,0.251037138743839,FALSE
+"H460","Pearson.est","adenosine receptor antagonist",-0.22484,-0.547,0.974,1255,1,"istradefylline",0.0114410431213845,0,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",-0.24893,-0.61,0.935,916,1,"lidamidine, midodrine, oxymetazoline, buphenine, clenbuterol",0.0291883891274822,0,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",-0.46215,-1.12,0.339,1247,0.873,"carvedilol, imiloxan, atipamezole, oxprenolol, vincamine",0.469800301796918,0.0589857562944303,FALSE
+"H460","Pearson.est","AKT inhibitor",0.19385,0.6,0.919,123,1,"GDC.0068, GSK2110183, MK.2206",0.0366844886138887,0,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.31824,-0.766,0.804,1441,1,"AZD3463",0.0947439512515487,0,FALSE
+"H460","Pearson.est","androgen receptor antagonist",-0.40086,-0.974,0.498,712,0.89,"cyproterone.acetate, RU.58841, nilutamide",0.302770657240282,0.0506099933550872,FALSE
+"H460","Pearson.est","antioxidant",-0.55753,-1.33,0.122,851,0.598,"rutin, taurine, trolox, chlorogenic.acid, mesna",0.913640169325252,0.223298816011589,FALSE
+"H460","Pearson.est","AP inhibitor",-0.39117,-0.926,0.594,635,0.988,"tanshinone.i, birinapant, embelin, LCL.161",0.226213555018806,0.00524305541237188,FALSE
+"H460","Pearson.est","ATPase inhibitor",-0.37845,-0.917,0.582,939,0.961,"digitoxin, blebbistatin...., evodiamine, digitoxigenin, NMS.873, digoxin",0.235077015350112,0.0172766123314547,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.63544,-1.53,0.0347,1021,0.324,"MK.8745, tozasertib, barasertib, barasertib.HQPA, CCT129202, MLN.8054, KW.2449, CCT137690, MK.5108, alisertib, GSK1070916, PHA.680632, AMG900, ENMD.2076, danusertib, SNS.314, AT.9283, hesperadin, PF.03814735",1.45967052520913,0.489454989793388,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54304,-1.33,0.127,1243,0.598,"tedizolid, radezolid, valnemulin",0.896196279044043,0.223298816011589,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.44114,-1.07,0.389,1438,0.863,"finafloxacin",0.410050398674292,0.0639892042847904,FALSE
+"H460","Pearson.est","BCL inhibitor",-0.44563,-1.08,0.347,1396,0.896,"TW.37, gossypol",0.459670525209126,0.0476919903378748,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.41786,-0.998,0.462,792,0.956,"ponatinib, flumatinib, GZD824, metatinib, tozasertib, nilotinib, bosutinib",0.335358024443874,0.0195421077238999,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.26698,0.813,0.687,117,0.931,"CL.218872, indiplon, bentazepam, nefiracetam",0.16304326294045,0.0310503190186574,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.42727,-1.02,0.432,643,0.92,"OTX015, PFI.1, JQ1...., I.BET.762, bromosporine",0.364516253185088,0.0362121726544447,FALSE
+"H460","Pearson.est","calcium channel blocker",-0.51528,-1.27,0.155,1077,0.706,"cinnarazine, carboxyamidotriazole, mibefradil, tetrandrine",0.809668301829709,0.151195298948196,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.48901,-1.19,0.254,1215,0.761,"ZK811752, SB.225002, navarixin",0.595166283380062,0.118615343229427,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.54832,-1.33,0.115,1126,0.598,"BMS.387032, R547, PHA.793887, aminopurvalanol.a, JNJ.7706621, TG.02, kenpaullone, alvocidib, BMS.265246, ribociclib, abemaciclib, AZD5438, palbociclib",0.939302159646388,0.223298816011589,FALSE
+"H460","Pearson.est","CHK inhibitor",0.4275,1.27,0.22,215,0.571,"PF.477736, SCH.900776, LY2606368, LY2603618",0.657577319177794,0.243363891754152,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.34487,-0.834,0.718,1111,1,"tepoxalin, piroxicam, tryptanthrin, ketoprofen, indoprofen, FR.122047",0.1438755557577,0,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",-0.32168,-0.785,0.773,619,1,"eplerenone, cobicistat, morin, itraconazole",0.111820506081675,0,FALSE
+"H460","Pearson.est","DNA alkylating agent",-0.39955,-0.984,0.484,655,0.913,"dianhydrogalactitol, temozolomide, cyclophosphamide, estramustine, carboplatin, satraplatin, TH.302, streptozotocin, melphalan, carmustine, mitomycin.c",0.315154638355588,0.039529222465701,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.35353,-0.847,0.685,1290,1,"melphalan, teroxirone, carmustine, oxaliplatin",0.164309428507574,0,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.25337,-0.62,0.916,591,1,"disulfiram, fdcyd, azacitidine, RG108, decitabine",0.0381045263321496,0,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",-0.65464,-1.58,0.026,1283,0.303,"foscarnet, trifluridine, idoxuridine",1.58502665202918,0.518557371497695,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.51182,-1.23,0.195,1101,0.711,"artesunate, enocitabine, CB.10.277, floxuridine, mitomycin.c, cyclocytidine, anisomycin",0.709965388637482,0.148130399270234,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",-0.40495,-0.982,0.483,1050,0.894,"amisulpride, piperacetazine, domperidone, mesoridazine, sertindole, raclopride, oxiperomide, paliperidone, UH.232....",0.316052869248488,0.0486624812040823,FALSE
+"H460","Pearson.est","estrogen receptor agonist",0.27473,0.834,0.692,139,0.969,"estradiol.cypionate, equol, levonorgestrel, ethinyl.estradiol",0.159893905543242,0.0136762229492347,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",0.32837,1.01,0.439,4,0.75,"toremifene",0.357535479757879,0.1249387366083,FALSE
+"H460","Pearson.est","FGFR inhibitor",0.33102,1.05,0.326,972,0.74,"erdafitinib, lenvatinib, AZD4547, orantinib, nintedanib, lucitanib, dovitinib, MK.2461, regorafenib, PD.173074",0.486782399932061,0.130768280269024,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.44515,-1.07,0.379,792,0.863,"ponatinib, dovitinib, midostaurin, TG.101348, lestaurtinib, tozasertib, gilteritinib, sunitinib, pacritinib, KW.2449, TG.02, ENMD.2076, quizartinib",0.421360790031928,0.0639892042847904,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",-0.32852,-0.804,0.729,934,1,"desonide, flumethasone.pivalate, fluticasone.propionate, halcinonide, prednisolone, rimexolone, flumethasone, halobetasol.propionate, fluocinolone.acetonide, ciclesonide, hydrocortisone",0.137272471682025,0,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.35052,1.08,0.31,945,0.767,"felbamate, CGP.37849, JNJ.16259685, tiletamine, kynurenic.acid, IEM1754, MTPG, LY456236, CPP, latrepirdine, diazooxonorleucine, ACDPP, SIB.1757",0.508638306165727,0.115204636051019,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.22609,-0.556,0.962,946,1,"TWS.119, tideglusib, kenpaullone",0.0168249279621871,0,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.58048,-1.38,0.104,901,0.648,"PHA.848125, lestaurtinib, GSK1904529A, GSK1838705A, danusertib, AZD3463",0.98296666070122,0.188424994129407,FALSE
+"H460","Pearson.est","HCV inhibitor",-0.43235,-1.05,0.399,1217,0.892,"narlaprevir, mericitabine",0.399027104313252,0.0496351456238769,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.21266,-0.512,0.98,574,0.993,"RGFP966, scriptaid, R306465, resminostat, romidepsin, JNJ.26481585, belinostat, trichostatin.a, AR.42, PCI.24781, RG2833, entinostat, givinostat, SB.939, dacinostat",0.00877392430750515,0.00305075150461883,FALSE
+"H460","Pearson.est","histamine receptor antagonist",-0.21489,-0.523,0.983,763,1,"levocetirizine, nizatidine, terfenadine, zolantidine, astemizole, BF2.649, pheniramine, tiotidine",0.00744648216786438,0,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.55687,1.7,0.0521,645,0.509,"pitavastatin, lovastatin, atorvastatin, mevastatin, fluvastatin, simvastatin",1.28316227670048,0.293282217663241,FALSE
+"H460","Pearson.est","HSP inhibitor",-0.49358,-1.18,0.264,1207,0.757,"ganetespib, SNX.2112, NVP.AUY922, tanespimycin, PU.H71",0.578396073130169,0.120904120499927,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.43913,-1.04,0.423,1041,0.89,"tozasertib, AZD1480, pacritinib, AZ960, WHI.P154, TG.101209, TG.02, AT.9283, filgotinib",0.373659632624958,0.0506099933550872,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.31204,-0.755,0.82,1151,1,"OSI.930, sunitinib, vatalanib, KI.8751",0.0861861476162833,0,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.73615,-1.81,0.00224,1170,0.0784,"RITA, idasanutlin, CGM097, serdemetan, nutlin.3",2.64975198166584,1.10568393731556,TRUE
+"H460","Pearson.est","MEK inhibitor",-0.77946,-1.91,0,1195,0.0811,"arctigenin, cobimetinib, refametinib, PD.198306, MEK162, trametinib, PD.184352, selumetinib, AS.703026, nobiletin, PD.318088, PD.0325901, TAK.733, AZD8330, Ro.4987655",Inf,1.09097914578884,TRUE
+"H460","Pearson.est","MET inhibitor",0.46325,1.47,0.0696,780,0.439,"INC.280, NVP.BVU972, AMG458, PF.04217903, LY2801653, PHA.665752",1.15739076038944,0.357535479757879,FALSE
+"H460","Pearson.est","microtubule inhibitor",-0.71337,-1.72,0.00682,1275,0.148,"cabazitaxel, secnidazole, vinflunine, D.64131, vinblastine, podophyllotoxin",2.16621562534352,0.829738284605043,TRUE
+"H460","Pearson.est","mTOR inhibitor",-0.40351,-0.987,0.497,737,0.932,"palomid.529, torin.2, WYE.125132, voxtalisib, SB.2343, PKI.179, deforolimus, LY303511, GSK2126458, NVP.BEZ235, AZD2014, PP242, WAY.600, AZD8055, MLN0128, XL388, torin.1, WYE.354, ku.0063794",0.303643611266668,0.0305840876460186,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",-0.21219,-0.509,0.977,719,0.979,"Ro.106.9920, parthenolide, bortezomib, betulinic.acid, EVP4593",0.0101054362812269,0.00921730819686218,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.55926,-1.37,0.101,950,0.622,"spiradoline, cebranopadol, salvinorin.a, trimebutine",0.995678626217357,0.206209615309181,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",0.32824,0.98,0.471,975,0.738,"talmapimod, SB.239063, TAK.715, SB.242235, VX.702, CMPD.1, skepinone.l",0.326979092871104,0.131943638176958,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.51074,-1.24,0.186,908,0.72,"AZD2461, niraparib, PJ.34, AG.14361, E7449, talazoparib",0.730487055782084,0.142667503568732,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.25466,-0.615,0.93,742,1,"axitinib, ponatinib, trapidil, dovitinib, regorafenib, CP.673451, SU014813, sunitinib, vatalanib, crenolanib, KI.8751",0.0315170514460649,0,FALSE
+"H460","Pearson.est","phosphatase inhibitor",0.14882,0.434,1,1234,0.995,"menadione, alexidine, BVT.948, AS.1949490, mycophenolate.mofetil, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate, mycophenolic.acid, GSK2830371",0,0.00217691925427455,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",0.20376,0.638,0.965,1155,1,"enoximone, trequinsin, avanafil, anagrelide, cilostamide, papaverine, YM.976, zardaverine, GSK256066, EMD.53998",0.0154726866562074,0,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.24808,-0.599,0.934,764,1,"BGT226, voxtalisib, GDC.0941, SB.2343, TG.100713, PKI.179, LY303511, GSK2126458, CUDC.907, NVP.BEZ235, YM.201636, PIK.75, ZSTK.474",0.0296531237699066,0,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.75156,-1.85,0.00554,1083,0.0797,"GW.843682X, BI.2536, NMS.1286937, GSK461364, HMN.214, volasertib, rigosertib",2.25649023527157,1.09854167860389,TRUE
+"H460","Pearson.est","potassium channel blocker",-0.33703,-0.821,0.732,486,1,"dofetilide, meglitinide, mepivacaine, ibutilide, ML133, oleoylethanolamide",0.135488918941608,0,FALSE
+"H460","Pearson.est","PPAR receptor agonist",-0.23955,-0.58,0.944,1015,1,"ciprofibrate, oleoylethanolamide",0.025028005701931,0,FALSE
+"H460","Pearson.est","progesterone receptor agonist",-0.26975,-0.667,0.892,953,1,"dienogest, melengestrol.acetate, tanaproget",0.0496351456238769,0,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.39375,1.2,0.224,881,0.602,"delanzomib, ONX.0914, oprozomib, carfilzomib, ixazomib.citrate, MG.132, bortezomib, ixazomib",0.649751981665837,0.220403508742175,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.63246,-1.55,0.0355,1285,0.324,"emetine, brefeldin.a, mercaptopurine, harringtonine, anguidine, bruceantin, cycloheximide, homoharringtonine",1.44977164694491,0.489454989793388,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.33269,-0.802,0.741,888,1,"mubritinib, BMS.599626, tyrphostin.A9, NVP.TAE226",0.130181792020672,0,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.50483,-1.24,0.201,1105,0.72,"SB.590885, CEP.32496, RAF265, dabrafenib, LGX818, AZ.628, GDC.0879",0.696803942579511,0.142667503568732,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.34496,-0.836,0.705,873,1,"regorafenib, cabozantinib, sunitinib",0.151810883008601,0,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.35923,-0.87,0.655,1392,1,"adarotene",0.183758700008217,0,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.44285,-1.08,0.369,924,0.896,"gemcitabine, cladribine, triapine, clofarabine, LY2334737",0.43297363384094,0.0476919903378748,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.53638,-1.3,0.123,1447,0.652,"aripiprazole",0.910094888560602,0.18575240426808,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.44652,-1.08,0.356,1068,0.896,"pirenperone, sertindole, paliperidone, SB.200646, aripiprazole",0.448550002027125,0.0476919903378748,FALSE
+"H460","Pearson.est","sodium channel blocker",-0.38465,-0.923,0.591,1013,0.971,"triamterene, butamben, mexiletine, benzethonium, ajmaline, A.803467",0.228412519118745,0.0127807700919951,FALSE
+"H460","Pearson.est","src inhibitor",-0.46449,-1.12,0.321,1133,0.873,"KX2.391, PP.2, TG.100572, bosutinib",0.493494967595128,0.0589857562944303,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.30791,-0.75,0.793,444,1,"posaconazole, chlormidazole, sulconazole, terconazole, lanoconazole, ketoconazole",0.100726812682396,0,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",0.42926,1.33,0.149,829,0.575,"LY2109761, SB.431542, repsox, D.4476, SB.525334, adaprev",0.826813731587726,0.24033215531037,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.61761,-1.5,0.0411,1141,0.351,"ftorafur, trifluridine, raltitrexed, carmofur",1.38615817812393,0.454692883534176,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.50043,-1.2,0.243,833,0.767,"irinotecan, nemorubicin, doxorubicin, camptothecin, SN.38, topotecan, exatecan.mesylate, fleroxacin, dexrazoxane, rubitecan, valrubicin, genz.644282, daunorubicin, voreloxin, teniposide, amonafide, idarubicin, amsacrine, TAS.103",0.614393726401688,0.115204636051019,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.66396,-1.59,0.0233,1027,0.338,"mebendazole, oxibendazole, paclitaxel, KX2.391, vindesine, indibulin, vincristine, plinabulin, nocodazole, CYT.997, docetaxel, ABT.751, BNC105, vinorelbine, vinblastine, dolastatin.10, podophyllotoxin, parbendazole, combretastatin.A.4, albendazole, taltobulin, verubulin, epothilone.b, fosbretabulin",1.63264407897398,0.471083299722345,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.2958,-0.717,0.819,873,1,"regorafenib, mubritinib, BMS.599626, cabozantinib, tyrphostin.A9, UNC2250, tivantinib, sunitinib, aminopurvalanol.a, NVP.TAE226",0.0867160982395816,0,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.2665,-0.644,0.92,817,1,"dovitinib, MK.2461, regorafenib, semaxanib, PD.173074, cabozantinib, SU014813, SAR131675, OSI.930, sunitinib, RAF265, vatalanib, TG.100572, ENMD.2076, KI.8751",0.0362121726544447,0,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",-0.35484,-0.852,0.677,847,1,"alfacalcidol, doxercalciferol, tacalcitol, ercalcitriol",0.169411331314856,0,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.8326,2.35,0,121,0.0105,"AZD8931, poziotinib, XL.647, canertinib, neratinib, gefitinib, lapatinib, BMS.690514, dacomitinib, osimertinib, erlotinib, tucatinib, ARRY.334543, afatinib, vandetanib, BMS.599626, PD.168393, CUDC.101, icotinib, WZ8040, AST.1306, pelitinib, BIBU.1361, PD.153035, CP.724714, AEE788, rociletinib, WZ.4002, GW.583340",Inf,1.97881070093006,TRUE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.32189,-0.752,0.804,998,1,"ponatinib, flumatinib, nilotinib, KW.2449, tozasertib, GZD824",0.0947439512515487,0,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.4728,-1.12,0.317,1189,0.73,"xanomeline, oxiracetam",0.498940737782249,0.136677139879544,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",-0.4804,-1.12,0.329,1151,0.73,"methscopolamine, iododexetimide",0.482804102050026,0.136677139879544,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",0.64509,1.76,0.00909,122,0.156,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",2.04143611677803,0.806875401645538,TRUE
+"H1299","Pearson.est","adrenergic receptor agonist",0.2568,0.734,0.824,1080,1,"isoxsuprine, methyldopa, oxymetazoline, isoetharine, ritodrine, norepinephrine, metaraminol, epinephrine, terbutaline, xylazine, A61603, clenbuterol, buphenine, lidamidine, midodrine",0.0840727883028842,0,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",-0.34419,-0.799,0.735,868,1,"pindolol, naftidrofuryl, metoprolol, oxprenolol, atipamezole, vincamine, idazoxan, carvedilol",0.133712660915805,0,FALSE
+"H1299","Pearson.est","AKT inhibitor",0.46108,1.34,0.146,243,0.356,"GDC.0068, uprosertib, CCT128930, GSK2110183, AZD5363, triciribine",0.835647144215563,0.448550002027125,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26514,0.741,0.796,1067,1,"GW.788388, brigatinib, SB.505124, NVP.TAE684, CEP.37440, alectinib, AP26113, AZD3463, crizotinib, DMH1, lorlatinib",0.0990869322623309,0,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",-0.26972,-0.638,0.913,551,0.952,"cyproterone.acetate, RU.58841, bicalutamide, flutamide, nilutamide",0.039529222465701,0.0213630516155257,FALSE
+"H1299","Pearson.est","antioxidant",0.53883,1.49,0.0708,671,0.301,"mesna, taurine, trolox, rutin, chlorogenic.acid, benfotiamine",1.14996674231023,0.521433504406157,FALSE
+"H1299","Pearson.est","AP inhibitor",-0.51716,-1.22,0.224,1012,0.668,"birinapant, GDC.0152, idronoxil",0.649751981665837,0.175223537524454,FALSE
+"H1299","Pearson.est","ATPase inhibitor",-0.71887,-1.69,0.0193,1165,0.122,"evodiamine, digitoxin, ouabain, k.strophanthidin, thonzonium, NMS.873, digitoxigenin, oligomycin.a, digoxin",1.71444269099223,0.913640169325252,TRUE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.64737,-1.55,0.0259,1167,0.31,"ZM.447439, GSK1070916, alisertib, KW.2449, tozasertib, MK.8745, barasertib.HQPA, hesperadin, CCT137690, AT.9283, barasertib, PF.03814735, MK.5108, AMG900, SNS.314, danusertib",1.58670023591875,0.508638306165727,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.30244,-0.703,0.847,940,0.993,"josamycin, radezolid, valnemulin",0.0721165896692931,0.00305075150461883,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.31494,-0.749,0.783,702,1,"sparfloxacin, trovafloxacin, sarafloxacin, norfloxacin, lomefloxacin, novobiocin",0.106238237942057,0,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.4493,-1.05,0.419,1229,0.861,"TW.37, gossypol",0.377785977033705,0.0649968485463452,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.37134,-0.875,0.653,998,1,"ponatinib, flumatinib, nilotinib, tozasertib, GZD824",0.185086818724926,0,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.22997,0.661,0.859,1118,1,"CL.218872, gamma.aminobutyric.acid, nefiracetam, piperazine, eprinomectin, lorazepam, zaleplon, bentazepam, CGS.20625, indiplon, ZK.93423, ivermectin, temazepam",0.0660068361687577,0,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",-0.3536,-0.825,0.688,634,1,"I.BET151, OTX015, PFI.1, bromosporine",0.162411561764489,0,FALSE
+"H1299","Pearson.est","calcium channel blocker",-0.33053,-0.765,0.746,1423,1,"carboxyamidotriazole",0.127261172527331,0,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.60278,-1.4,0.0927,913,0.507,"RS.504393, PF.04136309, MK.0812, SB.225002, UNBS.5162",1.0329202658555,0.294992040666664,FALSE
+"H1299","Pearson.est","CDK inhibitor",-0.33829,-0.795,0.743,880,1,"JNJ.7706621, AZD5438, kenpaullone, palbociclib, dinaciclib, R547, PHA.848125, BMS.265246, BMS.387032, indisulam, abemaciclib, PHA.793887",0.129011186239425,0,FALSE
+"H1299","Pearson.est","CHK inhibitor",-0.43828,-1.03,0.442,1191,0.884,"LY2606368, PF.477736",0.354577730650908,0.0535477349869269,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",-0.30549,-0.725,0.813,1096,1,"indoprofen, piroxicam, AM.404, naproxen, suxibuzone, tepoxalin",0.0899094544059319,0,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",-0.38331,-0.895,0.613,929,1,"clotrimazole, cobicistat, metyrapone",0.212539525481585,0,FALSE
+"H1299","Pearson.est","DNA alkylating agent",-0.38587,-0.904,0.615,904,1,"streptozotocin, estramustine, cisplatin, carboplatin, TH.302, dianhydrogalactitol, satraplatin, melphalan",0.211124884224583,0,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.38573,-0.908,0.577,1338,1,"valrubicin, melphalan, chlorambucil",0.238824186844269,0,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",0.24649,0.701,0.825,184,1,"azacitidine, fdcyd",0.0835460514500749,0,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",-0.41626,-0.965,0.52,1159,1,"trifluridine, idoxuridine, cephalomannine",0.283996656365201,0,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",-0.52826,-1.22,0.215,981,0.668,"nelarabine, azodicarbonamide, cyclocytidine, artesunate, enocitabine, cisplatin, CB.10.277, artemisinin, anisomycin",0.667561540084395,0.175223537524454,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",0.21578,0.617,0.916,264,1,"lurasidone, clebopride, domperidone, ziprasidone, remoxipride, acetophenazine, nemonapride, mesoridazine, oxiperomide",0.0381045263321496,0,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",0.29792,0.83,0.668,1019,1,"levonorgestrel, erteberel, ethinyl.estradiol, equol, estradiol.cypionate, PPT, estradiol, estrone",0.175223537524454,0,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.39952,-0.941,0.537,1139,1,"fulvestrant, toremifene",0.270025714300444,0,FALSE
+"H1299","Pearson.est","FGFR inhibitor",-0.50765,-1.19,0.246,1048,0.69,"MK.2461, dovitinib, nintedanib, erdafitinib, regorafenib",0.609064892896621,0.161150909262745,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.49502,-1.17,0.272,998,0.715,"ponatinib, lestaurtinib, TG.101348, dovitinib, KW.2449, tyrphostin.AG.1296, tozasertib, midostaurin, quizartinib, sorafenib",0.565431095965801,0.145693958198919,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",0.15179,0.417,0.991,1232,0.998,"triamcinolone.acetonide, ciclesonide, fludroxycortide, hydrocortisone, desonide, methylprednisolone, betamethasone, difluprednate, flumethasone.pivalate, dexamethasone.acetate, fluocinolone.acetonide, clobetasol.propionate, flumethasone, piretanide, prednisolone.acetate, triamcinolone, halobetasol.propionate, halcinonide, prednisolone, prednisolone.hemisuccinate, beclomethasone.dipropionate, rimexolone, deflazacort, fluticasone.propionate, fluorometholone",0.00392634551472468,0.000869458712628891,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.42771,1.21,0.204,164,0.488,"diazooxonorleucine, latrepirdine, CGP.37849, kynurenic.acid, SIB.1757",0.690369832574101,0.311580177997289,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",-0.27844,-0.66,0.882,926,0.983,"GSK.3.inhibitor.IX, TWS.119, kenpaullone, AZD2858, tideglusib",0.0545314148681803,0.00744648216786438,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",-0.36841,-0.873,0.649,927,1,"GSK1838705A, PHA.848125, lestaurtinib, danusertib",0.187755303199631,0,FALSE
+"H1299","Pearson.est","HCV inhibitor",-0.65176,-1.53,0.0424,1138,0.314,"Ro.9187, mericitabine, narlaprevir",1.37263414340727,0.503070351926785,FALSE
+"H1299","Pearson.est","HDAC inhibitor",-0.30694,-0.727,0.814,760,1,"R306465, ACY.1215, SB.939, trichostatin.a, givinostat, RG2833, AR.42, resminostat, scriptaid, chidamide, dacinostat, entinostat, belinostat",0.0893755951107988,0,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",-0.21575,-0.51,0.976,1180,0.994,"nizatidine, tiotidine, cimetidine",0.0105501823333082,0.00261361560268669,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",-0.84377,-2,0.00124,1408,0.0212,"pitavastatin, fluvastatin, mevastatin, atorvastatin",2.90657831483776,1.67366413907125,TRUE
+"H1299","Pearson.est","HSP inhibitor",-0.64908,-1.52,0.052,1247,0.3,"BIIB021, PU.H71, ganetespib, SNX.2112, NVP.AUY922, NMS.E973",1.2839966563652,0.522878745280338,FALSE
+"H1299","Pearson.est","JAK inhibitor",-0.36124,-0.849,0.67,1039,1,"lestaurtinib, TG.101348, AZ960, PRT062070, tozasertib, AT.9283",0.173925197299174,0,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.5337,-1.25,0.191,1107,0.656,"cediranib, OSI.930, motesanib, vatalanib, midostaurin, sorafenib, KI.8751, regorafenib, pazopanib",0.718966632752272,0.18309616062434,FALSE
+"H1299","Pearson.est","MDM inhibitor",-0.28205,-0.657,0.882,1222,0.968,"serdemetan",0.0545314148681803,0.0141246426916063,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.66475,2.05,0.00518,168,0.0514,"trametinib, AS.703026, selumetinib, cobimetinib, AZD8330, PD.0325901, TAK.733, Ro.4987655, MEK162, PD.318088, PD.198306, MEK1.2.inhibitor",2.28567024025477,1.28903688100472,TRUE
+"H1299","Pearson.est","MET inhibitor",-0.2762,-0.647,0.903,955,0.96,"AMG458, PHA.665752, LY2801653",0.0443122496864942,0.0177287669604316,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.72772,-1.7,0.00855,1273,0.133,"D.64131, podophyllotoxin, secnidazole, cabazitaxel, vinflunine, vinblastine",2.06803388527183,0.876148359032914,TRUE
+"H1299","Pearson.est","mTOR inhibitor",0.16318,0.456,1,1022,1,"GSK2126458, GDC.0980, LY303511, WYE.125132, voxtalisib, WAY.600, PP242, XL388, PI.103, OSI.027, torin.2, PF.04691502, SB.2343, everolimus, WYE.354, palomid.529, AZD2014, torin.1, AZD8055, temsirolimus, PF.05212384, MLN0128, NVP.BEZ235, ku.0063794, sirolimus, PKI.179, LY3023414",0,0,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.32517,-0.773,0.786,613,1,"curcumin, parthenolide...., bindarit, BAY.11.7082, betulinic.acid, bortezomib, parthenolide, IKK.2.inhibitor.V, EVP4593",0.104577453960592,0,FALSE
+"H1299","Pearson.est","opioid receptor agonist",-0.39109,-0.916,0.587,754,1,"salvinorin.a, trimebutine, cebranopadol, spiradoline",0.231361898752386,0,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",0.47606,1.39,0.0878,762,0.328,"SB.239063, talmapimod, SB.242235, TAK.715, skepinone.l, VX.702, CMPD.1",1.0565054840939,0.484126156288321,FALSE
+"H1299","Pearson.est","PARP inhibitor",-0.49206,-1.15,0.303,728,0.707,"PJ.34, niraparib, AG.14361, E7449, olaparib, AZD2461, talazoparib",0.518557371497695,0.150580586203101,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.55223,-1.3,0.145,1131,0.588,"trapidil, motesanib, SU014813, dovitinib, nintedanib, vatalanib, axitinib, crenolanib, CP.673451, sorafenib, KI.8751, regorafenib, pazopanib",0.838631997765025,0.230622673923862,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.40347,-0.925,0.587,935,1,"AS.1949490, BVT.948, CID.5458317, GSK2830371, bis.maltolato.oxovanadium.IV.",0.231361898752386,0,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",-0.28672,-0.68,0.864,962,0.982,"papaverine, zardaverine, YM.976, GSK256066",0.0634862575211067,0.00788851221305034,FALSE
+"H1299","Pearson.est","PI3K inhibitor",0.32666,0.883,0.553,92,1,"alpelisib, taselisib, GSK2126458, CH5132799, PI.828",0.257274868695302,0,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.81124,-1.88,0.00124,1169,0.0515,"GW.843682X, HMN.214, GSK461364, NMS.1286937, BI.2536, volasertib, rigosertib",2.90657831483776,1.28819277095881,TRUE
+"H1299","Pearson.est","potassium channel blocker",-0.50625,-1.19,0.245,850,0.69,"ibutilide, meglitinide, mepivacaine, dofetilide",0.610833915635468,0.161150909262745,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",-0.35854,-0.833,0.71,809,1,"ciprofibrate, clofibrate, GW.501516",0.148741651280925,0,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.18348,-0.435,0.994,799,0.994,"norgestrel, norethindrone, dienogest, tanaproget",0.00261361560268669,0.00261361560268669,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.59536,-1.38,0.0978,967,0.522,"bortezomib, ONX.0914, delanzomib, carfilzomib, ixazomib, MG.132",1.0096611452124,0.282329496997738,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.56802,-1.34,0.131,1206,0.515,"puromycin, cycloheximide, bruceantin, thiostrepton, harringtonine, mercaptopurine, homoharringtonine, anguidine",0.882728704344236,0.288192770958809,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.42594,1.19,0.219,72,0.473,"BMS.599626, AV.412, CP.724714",0.659555885159882,0.325138859262188,FALSE
+"H1299","Pearson.est","RAF inhibitor",-0.58449,-1.37,0.116,1250,0.508,"TAK.632, PLX.4720, RAF265, sorafenib, regorafenib",0.935542010773082,0.294136287716081,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.45537,-1.06,0.406,1345,0.866,"sorafenib, regorafenib",0.391473966422806,0.0624821079826534,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",0.31621,0.873,0.607,61,1,"CD.437, tamibarotene",0.216811308924742,0,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.59692,-1.41,0.0929,1302,0.527,"triapine, pentostatin, gemcitabine, cladribine, clofarabine",1.03198428600636,0.278189384787453,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",-0.55047,-1.28,0.185,1305,0.609,"pardoprunox, aripiprazole",0.732828271596986,0.215382707367125,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",-0.49817,-1.16,0.289,1316,0.71,"paliperidone, lerisetron, aripiprazole",0.539102157243452,0.148741651280925,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.5799,-1.36,0.138,971,0.496,"quinidine, mepivacaine, butamben, brivaracetam, triamterene, cibenzoline, benzethonium",0.860120913598763,0.304518323509803,FALSE
+"H1299","Pearson.est","src inhibitor",0.62004,1.74,0.0249,41,0.134,"saracatinib, dasatinib, ZM.306416",1.60380065290426,0.872895201635192,TRUE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.30205,-0.712,0.834,738,1,"lanoconazole, ketoconazole, posaconazole, chlormidazole",0.0788339493622613,0,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",0.51299,1.43,0.0931,227,0.317,"repsox, LY2109761, SB.431542",1.03105031901866,0.498940737782249,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",-0.27336,-0.636,0.894,664,0.937,"ftorafur, doxifluridine, raltitrexed, trifluridine",0.0486624812040823,0.0282604091122217,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.79476,-1.84,0.0025,1234,0.05,"genz.644282, amonafide, dexrazoxane, amsacrine, SN.38, nemorubicin, valrubicin, idarubicin, irinotecan, mitoxantrone, voreloxin, doxorubicin, epirubicin, TAS.103, rubitecan, etoposide, etoposide.phosphate, daunorubicin, teniposide, topotecan",2.60205999132796,1.30102999566398,TRUE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.77033,-1.82,0.00854,1175,0.0513,"parbendazole, mebendazole, epothilone.d, epothilone.b, albendazole, fenbendazole, plinabulin, fosbretabulin, ABT.751, dolastatin.10, podophyllotoxin, vinorelbine, KX2.391, CYT.997, paclitaxel, docetaxel, combretastatin.A.4, vincristine, vindesine, verubulin, taltobulin, BNC105, vinblastine",2.068542129311,1.28988263488818,TRUE
+"H1299","Pearson.est","tyrosine kinase inhibitor",0.26174,0.74,0.807,72,1,"vandetanib, BMS.599626, dasatinib, AV.412, CP.724714",0.0931264652779296,0,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.2861,-0.682,0.869,1048,0.998,"MK.2461, SAR131675, cediranib, OSI.930, motesanib, SU014813, dovitinib, nintedanib, vatalanib, tivozanib, axitinib, RAF265, sorafenib, KI.8751, regorafenib, pazopanib",0.0609802235513335,0.000869458712628891,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.73963,2.15,0,144,0.0363,"maxacalcitol, paricalcitol, tacalcitol",Inf,1.44009337496389,TRUE
+"HCC44","Pearson.est","EGFR inhibitor",-0.74153,-1.74,0.00917,1369,0.257,"WZ.4002, PD.168393, BMS.690514, BMS.599626, CUDC.101, icotinib, BIBU.1361, vandetanib, canertinib, lapatinib, PD.153035, osimertinib, neratinib, AST.1306, AZD8931, dacomitinib, pelitinib, gefitinib, afatinib, erlotinib, XL.647, poziotinib",2.03763066432998,0.590066876668705,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",-0.60626,-1.4,0.106,1396,0.58,"ZM.306416, bosutinib, dasatinib",0.97469413473523,0.236572006437063,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",0.19626,0.54,0.956,1165,0.971,"nefiracetam, xanomeline, oxiracetam, nicotine, tremorine, pilocarpine",0.0195421077238999,0.0127807700919951,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",0.51275,1.45,0.0855,347,0.906,"diphemanil, iododexetimide, darifenacin, methscopolamine",1.06803388527183,0.0428718023231869,FALSE
+"HCC44","Pearson.est","adenosine receptor antagonist",-0.63517,-1.49,0.0571,1352,0.582,"PSB.1115, CGS.15943",1.24336389175415,0.235077015350112,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.29171,-0.672,0.874,1217,1,"isoxsuprine, ritodrine, oxymetazoline",0.058488567365597,0,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",-0.21931,-0.515,0.965,922,1,"atenolol......, idazoxan, vincamine, atipamezole, naftidrofuryl, imiloxan, dronedarone",0.0154726866562074,0,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.41692,-0.962,0.515,953,0.893,"palomid.529, uprosertib, AZD5363, AT7867, triciribine",0.288192770958809,0.0491485411114536,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.37021,-0.86,0.668,822,1,"alectinib, lorlatinib, SB.505124, GW.788388, AP26113, AZD3463",0.175223537524454,0,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",0.24856,0.711,0.824,237,1,"flutamide, enzalutamide",0.0840727883028842,0,FALSE
+"HCC44","Pearson.est","antioxidant",-0.5485,-1.28,0.191,1398,0.542,"mesna",0.718966632752272,0.266000713461613,FALSE
+"HCC44","Pearson.est","AP inhibitor",0.25515,0.725,0.811,68,1,"idronoxil",0.090979145788844,0,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",0.32566,0.894,0.546,183,1,"oligomycin.a, omeprazole, rabeprazole",0.262807357295263,0,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.31183,-0.716,0.815,968,1,"hesperadin, CCT129202, MK.5108, danusertib, ENMD.2076, alisertib, CYC116, PHA.680632, GSK1070916",0.0888423912600234,0,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.58114,-1.36,0.124,912,0.647,"dirithromycin, azalomycin.b, azithromycin, tilmicosin, radezolid, valnemulin, tedizolid",0.906578314837765,0.1890957193313,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.45392,-1.08,0.358,1422,0.885,"finafloxacin",0.446116973356126,0.0530567293021746,FALSE
+"HCC44","Pearson.est","BCL inhibitor",0.39765,1.09,0.286,116,0.836,"oridonin, ABT.737, HA14.1",0.543633966870957,0.0777937225609836,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.55572,-1.31,0.137,1407,0.561,"bosutinib, dasatinib",0.863279432843593,0.251037138743839,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",-0.23279,-0.544,0.957,961,1,"CGS.20625, zaleplon, ZK.93423, eprinomectin, lorazepam, ivermectin",0.0190880622231565,0,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",0.30236,0.855,0.61,1012,0.99,"PFI.1, I.BET151, OTX015, I.BET.762, bromosporine, JQ1....",0.214670164989233,0.00436480540245009,FALSE
+"HCC44","Pearson.est","calcium channel blocker",-0.44882,-1.06,0.389,1228,0.901,"SKF.96365, cinnarazine, tetrandrine",0.410050398674292,0.045275209020937,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.43962,-1.02,0.426,1337,0.903,"navarixin, ZK811752",0.370590400897281,0.0443122496864942,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.57439,-1.33,0.149,1116,0.547,"BMS.387032, kenpaullone, palbociclib, PHA.848125, P276.00, BMS.265246, JNJ.7706621, aminopurvalanol.a, AT.7519, alvocidib, AZD5438",0.826813731587726,0.262012673666569,FALSE
+"HCC44","Pearson.est","CHK inhibitor",0.23084,0.64,0.91,62,0.971,"PF.477736",0.0409586076789064,0.0127807700919951,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",0.30121,0.84,0.602,101,0.964,"naproxen, AM.404, sulfasalazine, metoxibutropate, suxibuzone",0.220403508742175,0.0159229660971692,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.48228,-1.13,0.308,1082,0.821,"morin, eplerenone, itraconazole",0.511449283499556,0.0856568428805592,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",-0.25409,-0.594,0.921,959,1,"estramustine, streptozotocin, dacarbazine, temozolomide, cyclophosphamide, carmustine",0.0357403698031511,0,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.22682,-0.528,0.971,849,1,"primaquine, busulfan, nimorazole, oxaliplatin, teroxirone, metronidazole, sangivamycin, carmustine",0.0127807700919951,0,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.57187,-1.33,0.146,1309,0.547,"azacitidine, decitabine",0.835647144215563,0.262012673666569,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.53296,-1.27,0.182,1032,0.535,"foscarnet, cidofovir, trifluridine, adefovir.dipivoxil, idoxuridine",0.739928612014925,0.271646217978772,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",-0.27393,-0.641,0.89,1149,1,"capecitabine, cyclocytidine, CB.10.277, anisomycin",0.0506099933550872,0,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.44209,-1.03,0.451,1063,0.911,"piperacetazine, UH.232...., domperidone, clebopride, oxiperomide, acetophenazine, mesoridazine",0.345823458122039,0.0404816230270017,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",-0.24876,-0.587,0.936,948,1,"ethinyl.estradiol, estrone, PPT, erteberel",0.0287241512618947,0,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",0.33989,0.929,0.516,158,1,"toremifene, danazol",0.287350298372789,0,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",0.4823,1.34,0.148,284,0.788,"erdafitinib, nintedanib, lenvatinib, dovitinib, orantinib, regorafenib",0.829738284605043,0.103473782510445,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.21355,-0.498,0.98,893,0.997,"TG.02, GTP.14564, tandutinib, ENMD.2076, pacritinib, gilteritinib",0.00877392430750515,0.00130484168834428,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.66066,-1.53,0.0501,1182,0.549,"difluprednate, prednisolone.acetate, halcinonide, rimexolone, dexamethasone.acetate, flumethasone.pivalate, flumethasone, methylprednisolone, desonide, halobetasol.propionate, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, hydrocortisone",1.30016227413275,0.260427655549908,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",-0.27592,-0.636,0.873,1249,1,"diazooxonorleucine, SIB.1757",0.0589857562944303,0,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.26783,-0.62,0.909,1089,1,"TWS.119, kenpaullone, LY2090314",0.0414361167780325,0,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.57476,-1.35,0.139,1015,0.623,"danusertib, GSK1838705A, PHA.848125, AZD3463, GSK1904529A",0.856985199745905,0.20551195334083,FALSE
+"HCC44","Pearson.est","HCV inhibitor",-0.36096,-0.851,0.67,1109,1,"embelin, PSI.7976",0.173925197299174,0,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",0.31392,0.886,0.553,224,0.977,"mocetinostat, pyroxamide, vorinostat, ACY.1215, scriptaid, chidamide, resminostat, M.344",0.257274868695302,0.0101054362812269,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",-0.41138,-0.953,0.519,1020,0.886,"zolantidine, pheniramine, levocetirizine, ebastine, terfenadine, ranitidine, astemizole",0.284832642151542,0.0525662781129492,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",0.75935,2.11,0.00858,60,0.132,"mevastatin, pitavastatin, atorvastatin",2.06651271215129,0.87942606879415,TRUE
+"HCC44","Pearson.est","HSP inhibitor",-0.4145,-0.969,0.523,904,0.905,"tanespimycin, XL888, ganetespib, NVP.AUY922, SNX.2112, SNX.5422, PU.H71, BIIB021",0.281498311132726,0.0433514207947967,FALSE
+"HCC44","Pearson.est","JAK inhibitor",-0.33483,-0.787,0.741,871,1,"baricitinib, atiprimod, TG.02, AZ960, CEP.33779, AZD1480, TG.101209, pacritinib, WHI.P154, filgotinib",0.130181792020672,0,FALSE
+"HCC44","Pearson.est","KIT inhibitor",-0.25412,-0.601,0.92,1436,1,"dasatinib",0.0362121726544447,0,FALSE
+"HCC44","Pearson.est","MDM inhibitor",0.26283,0.768,0.715,1069,1,"AMG.232, serdemetan, CGM097, idasanutlin, nutlin.3, RITA",0.145693958198919,0,FALSE
+"HCC44","Pearson.est","MEK inhibitor",-0.77406,-1.8,0.00785,1295,0.295,"PD.184352, MEK162, refametinib, PD.318088, selumetinib, cobimetinib, Ro.4987655, AS.703026, PD.0325901, TAK.733, trametinib, AZD8330",2.10513034325475,0.530177984021837,FALSE
+"HCC44","Pearson.est","MET inhibitor",-0.36281,-0.844,0.671,992,1,"PHA.665752, LY2801653, PF.04217903",0.173277479831008,0,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",-0.27379,-0.641,0.886,954,1,"D.64131, cabazitaxel, vinblastine, cytochalasin.b, podophyllotoxin",0.0525662781129492,0,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",-0.39847,-0.932,0.566,1069,0.906,"voxtalisib, torin.1, PF.04691502, LY303511, OSI.027, AZD8055, PP242, XL388, WAY.600, WYE.354, GSK2126458",0.247183568811729,0.0428718023231869,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",-0.18799,-0.439,0.986,900,0.993,"EVP4593, bortezomib, curcumin, BAY.11.7085, betulinic.acid",0.0061230850587888,0.00305075150461883,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.42135,-0.995,0.494,652,0.904,"spiradoline, ADL5859, salvinorin.a, cebranopadol, trimebutine",0.306273051076353,0.0438315695246367,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",-0.55789,-1.29,0.174,809,0.547,"SB.242235, skepinone.l, VX.702, SB.239063, CMPD.1, TAK.715",0.7594507517174,0.262012673666569,FALSE
+"HCC44","Pearson.est","PARP inhibitor",0.2542,0.687,0.85,342,0.953,"AZD2461, olaparib, talazoparib, PJ.34",0.0705810742857073,0.0209070993616736,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.33372,0.915,0.538,290,1,"nintedanib, lenvatinib, pazopanib, linifanib, motesanib, axitinib, dovitinib, trapidil, orantinib, sorafenib, regorafenib, telatinib",0.269217724333611,0,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",0.35989,1,0.427,228,0.986,"bis.maltolato.oxovanadium.IV., BVT.948, menadione, CID.5458317",0.369572124974976,0.0061230850587888,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",0.2223,0.617,0.902,13,0.953,"enoximone",0.0447934624580583,0.0209070993616736,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",-0.47286,-1.11,0.324,941,0.84,"PIK.75, CH5132799, YM.201636, voxtalisib, PF.04691502, AZD6482, LY303511, buparlisib, taselisib, GDC.0941, alpelisib, TG.100713, GSK2126458",0.489454989793388,0.0757207139381184,FALSE
+"HCC44","Pearson.est","PLK inhibitor",-0.45064,-1.05,0.377,772,0.892,"BI.2536, GSK461364, GW.843682X, rigosertib, NMS.1286937",0.423658649794207,0.0496351456238769,FALSE
+"HCC44","Pearson.est","potassium channel blocker",0.25104,0.704,0.81,1086,0.97,"dofetilide, mepivacaine, meglitinide, ibutilide, ML133, oleoylethanolamide",0.0915149811213502,0.0132282657337552,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",0.51969,1.48,0.0991,178,1,"GW.501516, clofibrate, pterostilbene",1.00392634551472,0,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",0.49856,1.42,0.125,158,0.753,"norethindrone.acetate, norethindrone, norgestrel, danazol",0.903089986991944,0.123205023799299,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",0.41544,1.12,0.311,261,0.846,"delanzomib, ONX.0914, oprozomib, MG.132",0.507239610973163,0.0726296369609765,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",-0.33274,-0.78,0.747,786,1,"tedizolid.phosphate, florfenicol, chloramphenicol.palmitate, homoharringtonine, bruceantin, thiostrepton, emetine, cycloheximide, brefeldin.a",0.126679398184601,0,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.56854,-1.34,0.148,1374,0.603,"NVP.TAE226, BMS.599626, AV.412",0.829738284605043,0.219682687859849,FALSE
+"HCC44","Pearson.est","RAF inhibitor",-0.31407,-0.741,0.806,1014,1,"LGX818, CEP.32496, SB.590885, AZ.628",0.0936649581949093,0,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.6037,-1.41,0.109,1418,0.787,"vandetanib",0.962573502059376,0.104025267640935,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",0.43741,1.25,0.189,149,0.86,"fenretinide, adapalene, LE.135, bexarotene",0.723538195826756,0.0655015487564323,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.44038,1.21,0.22,250,0.831,"pentostatin, cladribine, hydroxyurea, fludarabine",0.657577319177794,0.080398976215889,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.42138,-0.993,0.484,1286,0.879,"ipsapirone",0.315154638355588,0.0560111249262281,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.42529,-0.996,0.473,1072,0.932,"SB.216641, pirenperone, RS.16566, SB.228357",0.325138859262188,0.0305840876460186,FALSE
+"HCC44","Pearson.est","sodium channel blocker",0.25567,0.716,0.803,25,1,"cibenzoline, oxcarbazepine",0.095284454721319,0,FALSE
+"HCC44","Pearson.est","src inhibitor",-0.73033,-1.7,0.0117,1268,0.186,"PP.2, ZM.306416, bosutinib, saracatinib, dasatinib",1.93181413825384,0.730487055782084,TRUE
+"HCC44","Pearson.est","sterol demethylase inhibitor",0.41401,1.18,0.242,259,0.796,"chlormidazole, ketoconazole, posaconazole",0.616184634019569,0.0990869322623309,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.60439,-1.4,0.0913,1175,0.58,"D.4476, repsox",1.0395292224657,0.236572006437063,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.73496,-1.72,0.00789,1138,0.204,"trifluridine, capecitabine, ftorafur, raltitrexed, carmofur",2.10292299679058,0.690369832574101,TRUE
+"HCC44","Pearson.est","topoisomerase inhibitor",-0.34027,-0.783,0.742,1124,1,"amsacrine, camptothecin, TAS.103, licochalcone.a, SN.38, idarubicin, exatecan.mesylate, fleroxacin",0.129596094720973,0,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.5069,-1.21,0.263,963,0.648,"vinblastine, dolastatin.10, vinorelbine, verubulin, plinabulin, paclitaxel, albendazole, oxibendazole, fosbretabulin, docetaxel, indibulin, podophyllotoxin, epothilone.b, parbendazole, nocodazole",0.580044251510242,0.188424994129407,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.55477,-1.29,0.175,1336,0.547,"aminopurvalanol.a, NVP.TAE226, tivantinib, BMS.599626, AV.412, vandetanib, dasatinib",0.756961951313706,0.262012673666569,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",-0.30144,-0.71,0.83,1391,1,"BMS.690514, ZM.306416, vandetanib, XL.647",0.0809219076239261,0,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",-0.59072,-1.4,0.109,1126,0.58,"alfacalcidol, ercalcitriol, tacalcitol",0.962573502059376,0.236572006437063,FALSE
+"A549","Pearson.est","EGFR inhibitor",-0.2672,-0.658,0.889,795,1,"ARRY.334543, tyrphostin.AG.494, CNX.2006, BMS.690514, dacomitinib, poziotinib, gefitinib, vandetanib, XL.647, afatinib, PD.153035, WZ8040, tyrphostin.AG.1478, pelitinib, PD.168393, erlotinib, OSI.420, icotinib, WZ.4002, BMS.599626",0.0510982390297863,0,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",-0.57696,-1.42,0.0984,1115,0.573,"KW.2449, flumatinib, GZD824, ponatinib, nilotinib, metatinib, bosutinib, dasatinib",1.00700490156866,0.24184537803261,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",-0.24936,-0.616,0.911,672,1,"tremorine, nicotine, pilocarpine",0.0404816230270017,0,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",0.28502,0.834,0.658,1037,0.775,"diphemanil, iododexetimide, hyoscyamine, darifenacin, dicycloverine, methscopolamine",0.181774106386044,0.11069829749369,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.26509,0.825,0.677,1066,0.745,"MRS.1220, SCH.58261, istradefylline, CGS.15943, sulmazole, theophylline, PSB.1115",0.169411331314856,0.127843727251707,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",-0.31283,-0.759,0.774,1030,1,"oxymetazoline, isoetharine, midodrine, buphenine, clenbuterol, isoxsuprine",0.111259039317107,0,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",-0.38915,-0.962,0.515,788,0.978,"prazosin, oxprenolol, RS.17053, carvedilol, pindolol, idazoxan, naftidrofuryl, dronedarone, imiloxan, vincamine, levobunolol, atipamezole",0.288192770958809,0.00966114521239857,FALSE
+"A549","Pearson.est","AKT inhibitor",0.39772,1.21,0.214,110,0.471,"GDC.0068, uprosertib, GSK2110183, MK.2206",0.669586226650809,0.326979092871104,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4207,-1.03,0.413,1444,0.95,"AZD3463",0.384049948343599,0.0222763947111523,FALSE
+"A549","Pearson.est","androgen receptor antagonist",-0.77344,-1.89,0.0024,1389,0.147,"nilutamide, cyproterone.acetate, RU.58841",2.61978875828839,0.832682665251824,TRUE
+"A549","Pearson.est","antioxidant",-0.59613,-1.47,0.0595,909,0.623,"taurine, chlorogenic.acid, mesna, trolox, rutin",1.22548303427145,0.20551195334083,FALSE
+"A549","Pearson.est","AP inhibitor",0.53398,1.57,0.0391,678,0.187,"embelin, idronoxil, tanshinone.i, birinapant, GDC.0152, LCL.161",1.40782324260413,0.728158393463501,TRUE
+"A549","Pearson.est","ATPase inhibitor",-0.5111,-1.26,0.201,1119,0.812,"digitoxin, digoxin, blebbistatin...., ouabain, digitoxigenin",0.696803942579511,0.0904439707588247,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.29338,-0.729,0.819,884,0.998,"MK.5108, hesperadin, SNS.314, alisertib, MLN.8054, KW.2449, CYC116, AT.9283, CCT129202, AMG900, PF.03814735",0.0867160982395816,0.000869458712628891,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.5828,-1.46,0.0896,1089,0.579,"tilmicosin, dirithromycin, valnemulin, radezolid, tedizolid",1.04769199033787,0.237321436272564,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.48335,-1.19,0.256,1433,0.849,"finafloxacin",0.59176003468815,0.0710923097560473,FALSE
+"A549","Pearson.est","BCL inhibitor",0.27012,0.791,0.749,133,0.756,"ABT.737, oridonin, HA14.1",0.125518182300534,0.121478204498793,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",-0.63302,-1.56,0.0375,1144,0.83,"flumatinib, GZD824, ponatinib, nilotinib, metatinib, bosutinib, dasatinib",1.42596873227228,0.0809219076239261,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",-0.3097,-0.761,0.781,1161,1,"lorazepam, CGS.20625, ivermectin, eprinomectin",0.1073489661227,0,FALSE
+"A549","Pearson.est","bromodomain inhibitor",0.85058,2.55,0,190,0.00497,"I.BET151, OTX015, PFI.1, JQ1...., I.BET.762",Inf,2.30364361126667,TRUE
+"A549","Pearson.est","calcium channel blocker",-0.20252,-0.499,0.988,1312,0.978,"cinnarazine",0.00524305541237188,0.00966114521239857,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",-0.39894,-0.992,0.494,1406,0.931,"navarixin",0.306273051076353,0.0310503190186574,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.54502,-1.35,0.122,1097,0.576,"CR8..R., NU6027, aminopurvalanol.a, JNJ.7706621, R547, abemaciclib, kenpaullone, PHA.848125, palbociclib, AZD5438, BMS.265246",0.913640169325252,0.239577516576788,FALSE
+"A549","Pearson.est","CHK inhibitor",0.51839,1.55,0.0517,11,0.152,"PF.477736",1.28650945690606,0.818156412055227,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",-0.24007,-0.585,0.95,947,1,"piroxicam, meloxicam, acetylsalicylsalicylic.acid, tepoxalin, FR.122047, ketoprofen, indoprofen, tryptanthrin",0.0222763947111523,0,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",-0.58287,-1.44,0.078,934,0.574,"metyrapone, cobicistat, eplerenone, itraconazole",1.10790539730952,0.241088107602027,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.44312,-1.1,0.352,764,0.964,"temozolomide, ifosfamide, dacarbazine, cyclophosphamide, melphalan, TH.302, carboplatin, carmustine, streptozotocin, mitomycin.c",0.453457336521869,0.0159229660971692,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.36606,-0.9,0.605,974,0.985,"melphalan, oxaliplatin, carboplatin, nimorazole, tirapazamine, valrubicin, carmustine, teroxirone",0.218244625347531,0.00656376950238827,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.38071,1.16,0.245,23,0.498,"SGI.1027",0.610833915635468,0.302770657240282,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",-0.30727,-0.757,0.774,1262,0.998,"idoxuridine, foscarnet",0.111259039317107,0.000869458712628891,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.54645,-1.35,0.149,1216,0.576,"CB.10.277, artesunate, floxuridine, mitomycin.c, cyclocytidine, anisomycin",0.826813731587726,0.239577516576788,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",-0.44472,-1.07,0.377,1145,0.938,"oxiperomide, amisulpride, piperacetazine, remoxipride, acetophenazine, mesoridazine, UH.232...., raclopride",0.423658649794207,0.0277971616209356,FALSE
+"A549","Pearson.est","estrogen receptor agonist",-0.33536,-0.825,0.714,1156,1,"estradiol, estrone",0.146301788223826,0,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.68394,2.06,0.0166,1,0.072,"toremifene",1.77989191195995,1.14266750356873,TRUE
+"A549","Pearson.est","FGFR inhibitor",-0.22677,-0.552,0.967,1381,0.972,"AZD4547",0.0145735259169983,0.0123337350737254,FALSE
+"A549","Pearson.est","FLT3 inhibitor",-0.36625,-0.891,0.618,769,0.955,"pacritinib, ENMD.2076, gilteritinib, TG.101348, tandutinib, KW.2449, GTP.14564, ponatinib, midostaurin, quizartinib",0.209011524911184,0.0199966284162537,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.55593,-1.37,0.134,1014,0.609,"methylprednisolone, dexamethasone.acetate, prednisolone, deflazacort, halcinonide, fludroxycortide, triamcinolone, flumethasone.pivalate, rimexolone, fluticasone.propionate, desonide, flumethasone, prednisolone.acetate, beclomethasone.dipropionate, ciclesonide, halobetasol.propionate, fluocinolone.acetonide",0.872895201635192,0.215382707367125,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.2729,0.834,0.649,161,0.775,"felbamate, CPP, CGP.37849",0.187755303199631,0.11069829749369,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.3269,-0.809,0.725,1318,0.999,"TWS.119, kenpaullone",0.139661993429006,0.000434511774017692,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",-0.63016,-1.54,0.0481,1371,0.708,"PHA.848125, AZD3463",1.31785492362617,0.149966742310231,FALSE
+"A549","Pearson.est","HCV inhibitor",-0.36842,-0.904,0.603,855,1,"narlaprevir, Ro.9187, mericitabine",0.219682687859849,0,FALSE
+"A549","Pearson.est","HDAC inhibitor",0.58289,1.79,0.024,248,0.119,"M.344, vorinostat, PCI.24781, tacedinaline, nexturastat.a, R306465, chidamide, NSC.3852, panobinostat, romidepsin, ACY.1215, trichostatin.a, pyroxamide, JNJ.26481585",1.61978875828839,0.924453038607469,TRUE
+"A549","Pearson.est","histamine receptor antagonist",-0.252,-0.606,0.93,979,1,"zolantidine, cimetidine, tiotidine, BF2.649, pheniramine, terfenadine, nizatidine",0.0315170514460649,0,FALSE
+"A549","Pearson.est","HMGCR inhibitor",0.33495,0.984,0.497,965,0.656,"pitavastatin, simvastatin, atorvastatin, mevastatin, lovastatin, fluvastatin",0.303643611266668,0.18309616062434,FALSE
+"A549","Pearson.est","HSP inhibitor",-0.33644,-0.82,0.707,1049,1,"BIIB021, NVP.AUY922, PU.H71, ganetespib, SNX.2112, tanespimycin",0.150580586203101,0,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.44934,-1.09,0.35,1102,0.953,"CEP.33779, AT.9283, AZ960, WHI.P154, TG.101209, filgotinib",0.455931955649724,0.0209070993616736,FALSE
+"A549","Pearson.est","KIT inhibitor",-0.30175,-0.732,0.823,1420,1,"KI.8751, dasatinib",0.0846001647877302,0,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.64964,-1.59,0.0238,1069,1,"serdemetan, nutlin.3, CGM097, idasanutlin, RITA",1.62342304294349,0,FALSE
+"A549","Pearson.est","MEK inhibitor",-0.40769,-1,0.461,854,0.939,"U.0126, PD.184352, trametinib, Ro.4987655, PD.198306, selumetinib, TAK.733, PD.0325901, refametinib, AZD8330, PD.318088, arctigenin, nobiletin",0.336299074610352,0.0273344077338891,FALSE
+"A549","Pearson.est","MET inhibitor",-0.3784,-0.926,0.574,804,1,"PHA.665752, NVP.BVU972, LY2801653, PF.04217903",0.241088107602027,0,FALSE
+"A549","Pearson.est","microtubule inhibitor",-0.41579,-1.01,0.449,810,0.942,"vinblastine, cabazitaxel, secnidazole, D.64131, cytochalasin.b, podophyllotoxin",0.347753658996677,0.0259490972071227,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.60826,-1.51,0.0639,958,0.681,"everolimus, OSI.027, deforolimus, PI.103, LY303511, PKI.179, palomid.529, voxtalisib, temsirolimus, WYE.125132, XL388, PP242, AZD2014, sirolimus, LY3023414, GSK2126458, NVP.BEZ235, GDC.0980, AZD8055, WAY.600, ku.0063794, MLN0128, SB.2343, WYE.354, torin.1",1.1944991418416,0.166852888087215,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",0.25891,0.766,0.781,304,0.749,"parthenolide...., Ro.106.9920, parthenolide, bortezomib, bindarit, curcumin, tyloxapol",0.1073489661227,0.125518182300534,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.49664,-1.2,0.251,830,0.864,"BW.180C, spiradoline, salvinorin.a, cebranopadol, trimebutine",0.600326278518962,0.0634862575211067,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",-0.23173,-0.57,0.953,598,0.978,"CMPD.1, SB.242235, TAK.715, VX.702, skepinone.l",0.0209070993616736,0.00966114521239857,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.41165,-1.03,0.443,1437,0.95,"E7449",0.35359627377693,0.0222763947111523,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37088,-0.91,0.597,1342,1,"CP.673451, KI.8751, crenolanib, dasatinib",0.224025668870631,0,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.25892,-0.637,0.898,1410,1,"mycophenolic.acid",0.0467236633326956,0,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",-0.33559,-0.817,0.715,1308,1,"zardaverine, YM.976",0.145693958198919,0,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.46642,-1.14,0.297,993,0.925,"PI.103, LY303511, YM.201636, BGT226, PKI.179, voxtalisib, PI3K.IN.2, TG.100713, LY3023414, GDC.0941, GSK2126458, ZSTK.474, NVP.BEZ235, GDC.0980, SB.2343",0.527243550682788,0.0338582672609674,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.46077,-1.14,0.309,763,0.925,"HMN.214, BI.2536, GSK461364, volasertib, rigosertib, GW.843682X",0.510041520575165,0.0338582672609674,FALSE
+"A549","Pearson.est","potassium channel blocker",-0.51452,-1.25,0.186,1203,0.795,"ibutilide, ML133",0.730487055782084,0.0996328713435297,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.5059,1.57,0.0432,719,0.187,"pterostilbene, clofibrate, GW.501516, ciprofibrate, fenofibrate, S26948, oleoylethanolamide",1.36451625318509,0.728158393463501,TRUE
+"A549","Pearson.est","progesterone receptor agonist",-0.41685,-1.02,0.445,1051,0.946,"dienogest, tanaproget, melengestrol.acetate",0.351639989019068,0.0241088635982073,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.51258,1.55,0.0783,231,0.152,"ONX.0914, carfilzomib, delanzomib, oprozomib, bortezomib",1.10623823794206,0.818156412055227,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.49133,-1.2,0.219,1210,0.864,"emetine, brefeldin.a, methacycline, cycloheximide, mercaptopurine, florfenicol",0.659555885159882,0.0634862575211067,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",-0.3291,-0.813,0.708,1083,1,"NVP.TAE226, mubritinib, BMS.599626",0.149966742310231,0,FALSE
+"A549","Pearson.est","RAF inhibitor",0.39358,1.15,0.268,154,0.468,"vemurafenib, TAK.632, regorafenib, AZ.628",0.571865205971211,0.329754146925876,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",0.35506,1.05,0.376,936,0.584,"regorafenib, sorafenib, sunitinib, cabozantinib, apatinib, vandetanib",0.424812155072339,0.233587152887601,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.65541,1.94,0.024,318,0.0828,"fenretinide, adapalene, adarotene, tamibarotene, AM.580, CD.437",1.61978875828839,1.08196966321512,TRUE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.26455,-0.646,0.899,894,1,"cladribine, clofarabine, triapine, gemcitabine",0.0462403082667712,0,FALSE
+"A549","Pearson.est","serotonin receptor agonist",-0.5982,-1.48,0.0652,1362,0.682,"aripiprazole, ipsapirone",1.18575240426808,0.166215625343521,FALSE
+"A549","Pearson.est","serotonin receptor antagonist",-0.23574,-0.578,0.932,1296,0.989,"RS.16566, aripiprazole",0.0305840876460186,0.0048037084028206,FALSE
+"A549","Pearson.est","sodium channel blocker",-0.36995,-0.905,0.586,1323,1,"A.803467, ajmaline, butamben",0.232102383981909,0,FALSE
+"A549","Pearson.est","src inhibitor",-0.43544,-1.08,0.359,1397,0.945,"bosutinib, dasatinib",0.444905551421681,0.0245681914907371,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",-0.36538,-0.892,0.601,670,0.977,"terconazole, sulconazole, lanoconazole, ketoconazole",0.22112552799726,0.0101054362812269,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",0.29126,0.868,0.58,1028,0.824,"LY2109761, D.4476, SB.525334, SB.431542, repsox, adaprev",0.236572006437063,0.0840727883028842,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",-0.5782,-1.41,0.0883,1253,0.548,"ftorafur, raltitrexed, carmofur",1.05403929642243,0.261219441515631,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.44189,-1.11,0.347,1319,0.975,"exatecan.mesylate, teniposide, voreloxin, amsacrine, fleroxacin, idarubicin, TAS.103",0.459670525209126,0.0109953843014632,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",-0.42805,-1.05,0.396,810,0.961,"vinblastine, fenbendazole, dolastatin.10, plinabulin, albendazole, taltobulin, docetaxel, ABT.751, CYT.997, BNC105, parbendazole, epothilone.d, combretastatin.A.4, KX2.391, podophyllotoxin, verubulin, epothilone.b",0.402304814074488,0.0172766123314547,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",-0.26078,-0.626,0.902,833,1,"cabozantinib, hypericin, apatinib, vandetanib, UNC2250, NVP.TAE226, GTP.14564, aminopurvalanol.a, mubritinib, BMS.599626, dasatinib",0.0447934624580583,0,FALSE
+"A549","Pearson.est","VEGFR inhibitor",-0.24381,-0.595,0.933,603,1,"tivozanib, sunitinib, SAR131675, semaxanib, SU014813, AEE788, motesanib, foretinib, PD.173074, TG.100572, ENMD.2076, RAF265, cabozantinib, nintedanib, BMS.690514, cediranib, vandetanib, ZM.306416, vatalanib, XL.647, telatinib, lucitanib, MGCD.265, KI.8751",0.0301183562535,0,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",-0.32022,-0.782,0.742,840,1,"alfacalcidol, ercalcitriol, tacalcitol",0.129596094720973,0,FALSE
+"H1703","Pearson.est","EGFR inhibitor",0.82362,2.03,0,57,0.0668,"poziotinib, AZD8931, gefitinib, dacomitinib, XL.647, neratinib, afatinib, canertinib, lapatinib, erlotinib, osimertinib, BIBU.1361, AST.1306, pelitinib, BMS.690514, PD.153035, vandetanib, CUDC.101, tucatinib, icotinib, BMS.599626, ARRY.334543, PD.168393, WZ8040",Inf,1.17522353752445,TRUE
+"H1703","Pearson.est","Abl kinase inhibitor",0.46962,1.2,0.265,104,0.877,"dasatinib, ZM.306416, bosutinib",0.576754126063192,0.0570004066339595,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",-0.28411,-0.709,0.807,1007,0.904,"nefiracetam, xanomeline, oxiracetam",0.0931264652779296,0.0438315695246367,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.56334,-1.38,0.126,1032,0.534,"diphemanil, darifenacin, iododexetimide, methscopolamine",0.899629454882437,0.272458742971444,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",0.68445,1.73,0.0294,170,0.216,"CGS.15943, MRS.1220, SCH.58261, PSB.1115",1.53165266958784,0.665546248849069,TRUE
+"H1703","Pearson.est","adrenergic receptor agonist",0.26044,0.654,0.893,150,0.977,"ritodrine, oxymetazoline, isoxsuprine",0.0491485411114536,0.0101054362812269,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",-0.30126,-0.735,0.782,1286,0.912,"metoprolol, carvedilol, pindolol",0.106793246940152,0.0400051616715838,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.4272,1.06,0.381,414,0.769,"uprosertib, triciribine, AZD5363, GDC.0068, CCT128930, MK.2206, GSK2110183, palomid.529",0.419075024324381,0.114073660198569,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.20058,0.526,0.968,523,1,"GW.788388, SB.505124, brigatinib, alectinib, AZD3463, CEP.37440, AP26113, NVP.TAE684",0.0141246426916063,0,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",-0.47712,-1.16,0.296,688,0.661,"cyproterone.acetate, bicalutamide, enzalutamide, RU.58841, nilutamide, flutamide",0.528708288941061,0.17979854051436,FALSE
+"H1703","Pearson.est","antioxidant",0.4485,1.12,0.306,44,0.921,"mesna",0.51427857351842,0.0357403698031511,FALSE
+"H1703","Pearson.est","AP inhibitor",-0.40077,-0.989,0.48,1417,0.77,"idronoxil",0.318758762624413,0.113509274827518,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.61923,-1.51,0.0802,984,0.498,"evodiamine, blebbistatin...., ouabain, omeprazole, k.strophanthidin, thonzonium, digitoxin, digitoxigenin, digoxin, oligomycin.a",1.09582563171584,0.302770657240282,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.63111,-1.57,0.0538,988,0.41,"hesperadin, TAK.901, alisertib, KW.2449, MK.5108, CCT137690, MK.8745, tozasertib, danusertib, barasertib.HQPA, AT.9283, aurora.a.inhibitor.i, ZM.447439, SNS.314, PF.03814735, AMG900, barasertib",1.26921772433361,0.387216143280265,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.21224,0.54,0.954,432,1,"tedizolid, azithromycin, azalomycin.b, tilmicosin",0.0204516252959049,0,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.31223,0.796,0.693,46,0.932,"finafloxacin",0.159266765388193,0.0305840876460186,FALSE
+"H1703","Pearson.est","BCL inhibitor",-0.32548,-0.794,0.711,776,0.916,"venetoclax, navitoclax, ABT.737, HA14.1, TW.37, oridonin",0.148130399270234,0.0381045263321496,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.40935,1.03,0.421,104,0.744,"dasatinib, bosutinib",0.375717904164332,0.128427064454121,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.17979,0.456,0.991,1190,0.99,"piperazine, CL.218872, lorazepam, zaleplon, ivermectin, eprinomectin, gamma.aminobutyric.acid, ZK.93423, CGS.20625, temazepam, bentazepam, nefiracetam, indiplon",0.00392634551472468,0.00436480540245009,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",0.39459,0.993,0.423,879,0.705,"JQ1...., OTX015, I.BET.762, I.BET151, bromosporine, PFI.1",0.373659632624958,0.151810883008601,FALSE
+"H1703","Pearson.est","calcium channel blocker",-0.32585,-0.795,0.738,1060,0.939,"penfluridol, pranidipine, SR.33805, carboxyamidotriazole",0.131943638176958,0.0273344077338891,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.3392,-0.827,0.648,1261,0.911,"MK.0812, UNBS.5162",0.188424994129407,0.0404816230270017,FALSE
+"H1703","Pearson.est","CDK inhibitor",0.19668,0.494,0.975,237,1,"indirubin, alvocidib, P276.00, TG.02, AZD5438",0.0109953843014632,0,FALSE
+"H1703","Pearson.est","CHK inhibitor",-0.34312,-0.832,0.652,1110,0.929,"SB.218078, PF.477736",0.18575240426808,0.0319842860063582,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",-0.39138,-0.977,0.459,1370,0.765,"tepoxalin, suxibuzone, AM.404, naproxen",0.338187314462739,0.116338564846382,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",-0.35725,-0.876,0.594,1104,0.9,"clotrimazole, metyrapone, cobicistat",0.226213555018806,0.0457574905606751,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.49277,-1.19,0.25,1080,0.666,"TH.302, mitomycin.c, carboplatin, satraplatin, cisplatin, dianhydrogalactitol, melphalan",0.602059991327962,0.176525770829699,FALSE
+"H1703","Pearson.est","DNA inhibitor",-0.4796,-1.14,0.32,1122,0.671,"tirapazamine, pibenzimol, carboplatin, valrubicin, melphalan, chlorambucil",0.494850021680094,0.173277479831008,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",0.46029,1.17,0.309,210,0.872,"azacitidine, decitabine, fdcyd",0.510041520575165,0.0594835150674328,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",-0.28929,-0.712,0.794,1123,0.921,"menadione, cephalomannine",0.100179497572904,0.0357403698031511,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.53567,-1.33,0.158,1157,0.518,"enocitabine, mitomycin.c, estramustine.phosphate, azodicarbonamide, cisplatin, artemisinin",0.801342913045577,0.285670240254767,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.42894,1.08,0.385,221,0.822,"domperidone, clebopride, lurasidone, acetophenazine, mesoridazine, oxiperomide",0.414539270491499,0.0851281824599496,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",0.35167,0.923,0.518,198,0.768,"erteberel, levonorgestrel, ethinyl.estradiol",0.285670240254767,0.114638779968488,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",0.43335,1.1,0.331,111,0.833,"clomifene, raloxifene",0.480172006224281,0.0793549985932124,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.58078,-1.4,0.121,1216,0.536,"regorafenib, lenvatinib, dovitinib, nintedanib, erdafitinib",0.91721462968355,0.27083521030723,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",-0.41291,-0.997,0.472,1036,0.812,"KW.2449, tyrphostin.AG.1296, tozasertib, quizartinib, sorafenib, TG.101348, midostaurin, dovitinib",0.326058001365912,0.0904439707588247,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",0.55382,1.41,0.0874,295,0.618,"hydrocortisone, triamcinolone.acetonide, ciclesonide, fluocinolone.acetonide, flumethasone.pivalate, desonide, difluprednate, methylprednisolone, dexamethasone.acetate, fludroxycortide, prednisolone, flumethasone, halobetasol.propionate",1.0584885673656,0.209011524911184,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.39271,1.01,0.427,340,0.708,"diazooxonorleucine, SIB.1757, CGP.37849, IEM1754, kynurenic.acid, latrepirdine, CPP",0.369572124974976,0.149966742310231,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.33722,0.85,0.618,152,0.869,"indirubin, LY2090314",0.209011524911184,0.0609802235513335,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",0.30297,0.771,0.676,71,0.942,"GSK1904529A",0.170053304058364,0.0259490972071227,FALSE
+"H1703","Pearson.est","HCV inhibitor",-0.35152,-0.864,0.612,1038,0.896,"Ro.9187, mericitabine, narlaprevir",0.213248577854439,0.0476919903378748,FALSE
+"H1703","Pearson.est","HDAC inhibitor",-0.19195,-0.471,0.99,677,0.986,"trichostatin.a, AR.42, vorinostat, M.344, R306465, nexturastat.a, RGFP966, mocetinostat, dacinostat, NSC.3852, ACY.1215, SB.939, belinostat, pyroxamide, RG2833, entinostat, resminostat, scriptaid, chidamide",0.00436480540245009,0.0061230850587888,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.29217,0.733,0.753,181,0.936,"ranitidine, terfenadine, levocetirizine, astemizole",0.123205023799299,0.0287241512618947,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.94383,-2.26,0,1408,0,"fluvastatin, mevastatin, atorvastatin, pitavastatin",Inf,Inf,TRUE
+"H1703","Pearson.est","HSP inhibitor",-0.52095,-1.28,0.211,1069,0.584,"PU.H71, SNX.2112, NVP.AUY922, ganetespib, NMS.E973",0.675717544702307,0.233587152887601,FALSE
+"H1703","Pearson.est","JAK inhibitor",-0.27921,-0.678,0.842,1154,0.921,"tozasertib, ruxolitinib, AT.9283, TG.101348, PRT062070",0.0746879085003505,0.0357403698031511,FALSE
+"H1703","Pearson.est","KIT inhibitor",-0.50547,-1.24,0.232,1180,0.598,"telatinib, cediranib, regorafenib, sorafenib, midostaurin, motesanib, lenvatinib, pazopanib",0.6345120151091,0.223298816011589,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.37108,-0.901,0.586,1121,0.882,"AMG.232, serdemetan",0.232102383981909,0.0545314148681803,FALSE
+"H1703","Pearson.est","MEK inhibitor",0.84685,2.18,0,107,0.0169,"trametinib, AS.703026, cobimetinib, AZD8330, TAK.733, PD.0325901, selumetinib, Ro.4987655, MEK162, PD.318088, refametinib, PD.198306, PD.184352",Inf,1.77211329538633,TRUE
+"H1703","Pearson.est","MET inhibitor",-0.40727,-1,0.442,1126,0.836,"LY2801653, AMG458",0.354577730650908,0.0777937225609836,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.61266,-1.49,0.0643,881,0.429,"triclabendazole, colchicine, D.64131, cytochalasin.b, podophyllotoxin, estramustine.phosphate, cabazitaxel, secnidazole, vinflunine, vinblastine",1.19178902707578,0.367542707815276,FALSE
+"H1703","Pearson.est","mTOR inhibitor",0.26649,0.663,0.832,378,0.999,"GSK2126458, LY303511, PP242, WAY.600, XL388, WYE.354, OSI.027, PF.04691502, GDC.0980, voxtalisib, WYE.125132",0.0798766737092761,0.000434511774017692,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.19837,-0.48,0.981,1325,1,"BAY.11.7082",0.0083309926200515,0,FALSE
+"H1703","Pearson.est","opioid receptor agonist",-0.22538,-0.54,0.957,325,1,"ADL5859, trimebutine, BW.180C, cebranopadol, salvinorin.a, spiradoline",0.0190880622231565,0,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.54823,1.39,0.135,658,0.584,"SB.239063, TAK.715, talmapimod, SB.242235, skepinone.l, CMPD.1, VX.702",0.869666231504994,0.233587152887601,FALSE
+"H1703","Pearson.est","PARP inhibitor",-0.59277,-1.45,0.0952,1307,0.471,"olaparib, AZD2461, talazoparib",1.02136305161553,0.326979092871104,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.55008,-1.35,0.161,1171,0.515,"crenolanib, telatinib, trapidil, regorafenib, CP.673451, linifanib, sorafenib, motesanib, lenvatinib, dovitinib, axitinib, nintedanib, pazopanib",0.79317412396815,0.288192770958809,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.42808,-1.05,0.407,1062,0.765,"AS.1949490, menadione, BVT.948, GSK2830371, bis.maltolato.oxovanadium.IV.",0.39040559077478,0.116338564846382,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",-0.40968,-0.996,0.476,1176,0.785,"zardaverine, YM.976, enoximone, GSK256066",0.322393047279507,0.105130343254747,FALSE
+"H1703","Pearson.est","PI3K inhibitor",0.4203,1.05,0.398,351,0.746,"alpelisib, taselisib, GSK2126458, TG.100713, CH5132799, LY303511, GDC.0941, PIK.75, PF.04691502, PI.828, GDC.0980, AZD6482, voxtalisib",0.400116927926312,0.127261172527331,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.64391,-1.59,0.0495,1127,0.726,"GSK461364, HMN.214, BI.2536, rigosertib, volasertib",1.30539480106643,0.139063379299906,FALSE
+"H1703","Pearson.est","potassium channel blocker",-0.5592,-1.36,0.151,1416,0.534,"dofetilide",0.821023052706831,0.272458742971444,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",-0.44832,-1.12,0.342,1054,0.655,"pterostilbene, clofibrate, GW.501516",0.465973893943865,0.183758700008217,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.31414,-0.767,0.75,982,0.911,"danazol, dienogest, tanaproget, norgestrel, norethindrone",0.1249387366083,0.0404816230270017,FALSE
+"H1703","Pearson.est","proteasome inhibitor",-0.45691,-1.12,0.324,926,0.655,"ixazomib, oprozomib, delanzomib, ONX.0914, MG.132",0.489454989793388,0.183758700008217,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.51746,-1.27,0.21,1161,0.569,"thiostrepton, clofoctol, puromycin, bruceantin, mercaptopurine, homoharringtonine, harringtonine, anguidine",0.677780705266081,0.244887733604929,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",0.54835,1.43,0.105,200,0.664,"BMS.599626, AV.412, NVP.TAE226, CP.724714",0.978810700930062,0.177831920631982,FALSE
+"H1703","Pearson.est","RAF inhibitor",0.30081,0.767,0.733,156,0.914,"AZ.628, CEP.32496, SB.590885",0.134896025358872,0.0390538042661686,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.44018,1.11,0.323,29,0.873,"vandetanib",0.490797477668897,0.0589857562944303,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",0.40017,1.01,0.441,48,0.708,"CD.437, tamibarotene",0.355561410532161,0.149966742310231,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.63686,-1.57,0.0595,963,0.41,"hydroxyurea, fludarabine.phosphate, triapine, gemcitabine, fludarabine, cladribine, clofarabine, pentostatin",1.22548303427145,0.387216143280265,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",-0.62589,-1.57,0.0587,1151,0.41,"SR.57227A, pardoprunox, aripiprazole",1.23136189875239,0.387216143280265,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",-0.47896,-1.17,0.268,1262,0.674,"paliperidone, lerisetron, aripiprazole",0.571865205971211,0.17134010346468,FALSE
+"H1703","Pearson.est","sodium channel blocker",-0.25562,-0.619,0.909,1021,0.963,"brivaracetam, triamterene, oxcarbazepine, butamben, cibenzoline",0.0414361167780325,0.0163737128754655,FALSE
+"H1703","Pearson.est","src inhibitor",0.66148,1.76,0.0208,104,0.224,"saracatinib, dasatinib, ZM.306416, bosutinib",1.68193666503724,0.649751981665837,TRUE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.31245,-0.772,0.73,1392,0.927,"chlormidazole",0.136677139879544,0.0329202658555029,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.38532,0.99,0.458,480,0.679,"repsox, D.4476, SB.431542, LY2109761",0.339134521996131,0.168130225719498,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",0.46965,1.2,0.249,364,0.877,"carmofur, capecitabine, raltitrexed",0.603800652904264,0.0570004066339595,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.73872,-1.81,0.0152,1243,0.23,"irinotecan, dexrazoxane, rubitecan, voreloxin, doxorubicin, valrubicin, mitoxantrone, TAS.103, amonafide, nemorubicin, daunorubicin, teniposide, etoposide, topotecan, etoposide.phosphate, epirubicin",1.81815641205523,0.638272163982407,TRUE
+"H1703","Pearson.est","tubulin polymerization inhibitor",-0.60989,-1.5,0.0875,973,0.458,"fosbretabulin, epothilone.b, podophyllotoxin, mebendazole, fenbendazole, flubendazole, plinabulin, vinorelbine, docetaxel, epothilone.d, ABT.751, dolastatin.10, paclitaxel, CYT.997, vincristine, combretastatin.A.4, vindesine, KX2.391, vinblastine, verubulin, taltobulin, BNC105",1.05799194697769,0.339134521996131,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.41593,1.06,0.374,200,0.769,"vandetanib, dasatinib, BMS.599626, AV.412, NVP.TAE226, hypericin, GTP.14564, CP.724714",0.42712839779952,0.114073660198569,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",-0.30703,-0.751,0.753,1180,0.912,"telatinib, cediranib, regorafenib, SAR131675, RAF265, linifanib, sorafenib, motesanib, lenvatinib, dovitinib, axitinib, tivozanib, nintedanib, pazopanib",0.123205023799299,0.0400051616715838,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.70695,1.79,0.0187,321,0.254,"tacalcitol, paricalcitol, calcitriol, maxacalcitol, ercalcitriol, alfacalcidol",1.7281583934635,0.595166283380062,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",0.7297,1.75,0.00865,80,0.649,"gefitinib, poziotinib, afatinib, pelitinib, XL.647, CUDC.101, AZD8931, erlotinib, dacomitinib, BIBU.1361, AST.1306, osimertinib, lapatinib, neratinib, vandetanib, canertinib, icotinib, PD.153035, WZ.4002, tucatinib",2.06298389253519,0.187755303199631,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",0.56625,1.35,0.148,484,0.67,"dasatinib, ZM.306416, tozasertib, GZD824, nilotinib, ponatinib, imatinib, bosutinib",0.829738284605043,0.173925197299174,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",-0.3505,-0.923,0.483,1398,0.728,"nefiracetam",0.316052869248488,0.137868620686963,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.27741,-0.739,0.748,1143,0.878,"darifenacin, diphemanil, methscopolamine",0.126098402135539,0.0565054840938974,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",0.48282,1.19,0.243,301,0.717,"istradefylline, sulmazole, CGS.15943, PSB.1115",0.614393726401688,0.1444808443322,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",0.30493,0.732,0.778,334,0.955,"ritodrine, terbutaline, oxymetazoline, methyldopa, isoxsuprine",0.109020403010311,0.0199966284162537,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",-0.3474,-0.935,0.538,1306,0.74,"levobunolol, metoprolol, propranolol, pindolol",0.269217724333611,0.130768280269024,FALSE
+"HCC15","Pearson.est","AKT inhibitor",0.38654,0.927,0.548,384,0.793,"uprosertib, MK.2206, GSK2110183, triciribine, AT7867",0.261219441515631,0.100726812682396,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.49057,1.17,0.273,400,0.697,"lorlatinib, SB.505124, CEP.37440, alectinib, AZD3463",0.563837352959244,0.156767221901991,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.82341,-2.22,0.00342,1256,0.0411,"flutamide, RU.58841, enzalutamide, cyproterone.acetate",2.46597389394387,1.38615817812393,TRUE
+"HCC15","Pearson.est","antioxidant",-0.45702,-1.2,0.266,1426,0.628,"taurine, rutin",0.575118363368933,0.202040356262804,FALSE
+"HCC15","Pearson.est","AP inhibitor",-0.43189,-1.16,0.257,1212,0.653,"birinapant, LCL.161, GDC.0152",0.590066876668705,0.185086818724926,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",-0.48383,-1.3,0.193,1266,0.707,"omeprazole, digitoxin, rabeprazole, digitoxigenin, oligomycin.a",0.714442690992226,0.150580586203101,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",0.12973,0.308,0.999,320,1,"GSK1070916, tozasertib, ENMD.2076",0.000434511774017692,0,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.26389,-0.709,0.792,380,0.858,"tedizolid, valnemulin, azithromycin, tilmicosin, azalomycin.b, dirithromycin, radezolid, josamycin",0.101274818410506,0.0665127121512946,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.21394,0.514,0.978,380,0.989,"finafloxacin, novobiocin, sarafloxacin",0.00966114521239857,0.0048037084028206,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.34132,0.809,0.67,346,0.886,"obatoclax, gossypol, venetoclax",0.173925197299174,0.0525662781129492,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.57356,1.38,0.122,484,0.921,"dasatinib, tozasertib, GZD824, nilotinib, ponatinib, imatinib, bosutinib",0.913640169325252,0.0357403698031511,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.26517,0.64,0.891,543,0.961,"ZK.93423, piperazine, bentazepam, zaleplon, CL.218872, eprinomectin",0.0501222959631252,0.0172766123314547,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.46165,1.14,0.31,491,0.701,"JQ1...., I.BET.762, OTX015, I.BET151",0.508638306165727,0.154281982033341,FALSE
+"HCC15","Pearson.est","calcium channel blocker",0.41373,0.993,0.461,560,0.737,"tetrandrine, SKF.96365, efonidipine.monoethanolate, penfluridol, mibefradil, fendiline",0.336299074610352,0.132532512140949,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.55356,1.35,0.155,173,0.67,"ZK811752, PF.04136309",0.809668301829709,0.173925197299174,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.49761,1.18,0.295,385,0.706,"indisulam, P276.00, alvocidib, AT.7519, TG.02, dinaciclib, AZD5438, ribociclib, PHA.848125, palbociclib, JNJ.7706621",0.530177984021837,0.151195298948196,FALSE
+"HCC15","Pearson.est","CHK inhibitor",-0.32408,-0.875,0.615,467,0.747,"LY2603618, AZD7762, LY2606368, PF.477736, SCH.900776, CHIR.124, SB.218078",0.211124884224583,0.126679398184601,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.4483,-1.24,0.2,1347,0.611,"AM.404, sulfasalazine, metoxibutropate, suxibuzone, naproxen",0.698970004336019,0.213958789757446,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",0.49946,1.2,0.252,165,0.731,"morin, metyrapone",0.598599459218456,0.13608262304214,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",-0.38211,-1.04,0.329,1151,0.623,"streptozotocin, ifosfamide, melphalan, satraplatin, cisplatin, dianhydrogalactitol, mitomycin.c",0.482804102050026,0.20551195334083,FALSE
+"HCC15","Pearson.est","DNA inhibitor",0.22993,0.549,0.945,229,0.992,"sangivamycin, carmustine, bendamustine",0.0245681914907371,0.00348832784582135,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.39417,0.945,0.502,225,0.782,"decitabine, azacitidine",0.299296282854981,0.106793246940152,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.40542,0.994,0.467,193,0.758,"cidofovir, idoxuridine",0.330683119433888,0.120330794367946,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",-0.60115,-1.68,0.0639,1322,0.286,"floxuridine, cisplatin, artemisinin, estramustine.phosphate, mitomycin.c",1.1944991418416,0.543633966870957,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",0.45684,1.08,0.391,250,0.687,"clebopride, lurasidone, domperidone, mesoridazine, sertindole, amisulpride, thioproperazine",0.407823242604133,0.16304326294045,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.29437,-0.81,0.645,1442,0.828,"estradiol.cypionate",0.190440285364732,0.0819696632151199,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",0.63709,1.55,0.0579,134,0.529,"raloxifene, clomifene",1.23732143627256,0.276544327964814,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.40749,0.998,0.457,318,0.774,"PD.173074, MK.2461, lucitanib, regorafenib",0.34008379993015,0.111259039317107,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.4217,1.03,0.417,430,0.736,"gilteritinib, pacritinib, tozasertib, TG.02, sunitinib, ENMD.2076, sorafenib, ponatinib, tyrphostin.AG.1296",0.379863945026242,0.133122185662501,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",0.52471,1.25,0.208,327,0.687,"hydrocortisone, ciclesonide, triamcinolone.acetonide, difluprednate, flumethasone.pivalate, halcinonide, halobetasol.propionate, fluocinolone.acetonide, prednisolone.acetate, desonide, prednisolone",0.681936665037238,0.16304326294045,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",0.28399,0.693,0.832,354,0.965,"SIB.1757, CPP, diazooxonorleucine, CGP.37849",0.0798766737092761,0.0154726866562074,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.18838,-0.512,0.971,1218,0.978,"indirubin, CHIR.98014",0.0127807700919951,0.00966114521239857,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",0.46534,1.13,0.317,501,0.664,"GSK1904529A, GSK1838705A, PHA.848125, AZD3463, lestaurtinib, danusertib",0.498940737782249,0.177831920631982,FALSE
+"HCC15","Pearson.est","HCV inhibitor",0.34683,0.83,0.679,47,0.897,"embelin",0.168130225719498,0.0472075569559079,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.51246,1.26,0.221,360,0.706,"PCI.24781, R306465, M.344, romidepsin, JNJ.26481585, dacinostat, givinostat, belinostat, trichostatin.a, NSC.3852, vorinostat, panobinostat, tacedinaline, entinostat, nexturastat.a",0.655607726314889,0.151195298948196,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",0.34689,0.828,0.671,479,0.877,"ranitidine, astemizole, pheniramine, ebastine, chloropyramine, tecastemizole, lafutidine",0.173277479831008,0.0570004066339595,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",0.48141,1.16,0.295,470,0.688,"lovastatin, pitavastatin, simvastatin",0.530177984021837,0.162411561764489,FALSE
+"HCC15","Pearson.est","HSP inhibitor",-0.4397,-1.14,0.286,1253,0.642,"XL888, KW.2478, alvespimycin, VER.49009, tanespimycin",0.543633966870957,0.192464971931147,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.37889,0.91,0.574,389,0.803,"atiprimod, pacritinib, tozasertib, TG.02, filgotinib, AZD1480",0.241088107602027,0.095284454721319,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.27329,0.658,0.885,483,0.962,"dasatinib, sunitinib, regorafenib, sorafenib, imatinib, vatalanib",0.0530567293021746,0.0168249279621871,FALSE
+"HCC15","Pearson.est","MDM inhibitor",0.43923,1.09,0.364,154,0.692,"nutlin.3, idasanutlin",0.438898616350944,0.159893905543242,FALSE
+"HCC15","Pearson.est","MEK inhibitor",0.69964,1.72,0.0189,156,0.421,"cobimetinib, AZD8330, MEK162, TAK.733, AS.703026, trametinib, PD.0325901, Ro.4987655, selumetinib, MEK1.2.inhibitor",1.72353819582676,0.375717904164332,FALSE
+"HCC15","Pearson.est","MET inhibitor",-0.62128,-1.69,0.0635,1099,0.34,"INC.280, AMG458, NVP.BVU972",1.19722627470802,0.468521082957745,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",-0.35202,-0.961,0.494,1358,0.729,"cytochalasin.b, estramustine.phosphate",0.306273051076353,0.137272471682025,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",0.2973,0.715,0.79,145,0.957,"GSK2126458, WAY.600, LY303511, XL388, OSI.027",0.102372908709559,0.0190880622231565,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.52477,1.26,0.209,266,0.706,"curcumin, parthenolide...., bortezomib, Ro.106.9920, parthenolide",0.679853713888946,0.151195298948196,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",-0.40083,-1.06,0.395,578,0.626,"trimebutine, salvinorin.a, cebranopadol, ADL5859, BW.180C, spiradoline",0.40340290437354,0.20342566678957,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",0.56299,1.34,0.153,583,0.642,"SB.242235, SB.239063, TAK.715, CMPD.1, talmapimod, VX.702",0.815308569182401,0.192464971931147,FALSE
+"HCC15","Pearson.est","PARP inhibitor",-0.41383,-1.11,0.295,1235,0.612,"olaparib, AZD2461, E7449",0.530177984021837,0.213248577854439,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.19253,-0.522,0.959,1173,1,"crenolanib, lenvatinib, motesanib, tandutinib, trapidil, nintedanib, linifanib",0.0181813928293364,0,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.50615,1.21,0.232,361,0.749,"GSK2830371, alexidine, CID.5458317, bis.maltolato.oxovanadium.IV., sodium.stibogluconate",0.6345120151091,0.125518182300534,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.39081,-1.07,0.361,1157,0.644,"zardaverine, papaverine, GSK256066, YM.976, enoximone",0.442492798094342,0.191114132640188,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",0.35581,0.853,0.657,503,0.879,"buparlisib, YM.201636, GSK2126458, LY303511, TG.100713, taselisib, GDC.0941, PIK.75, AZD6482, CUDC.907, PF.04691502, pilaralisib, PF.05212384",0.182434630440219,0.0560111249262281,FALSE
+"HCC15","Pearson.est","PLK inhibitor",-0.48448,-1.32,0.185,1111,0.757,"GSK461364, HMN.214, GW.843682X, BI.2536, volasertib",0.732828271596986,0.120904120499927,FALSE
+"HCC15","Pearson.est","potassium channel blocker",-0.47471,-1.27,0.184,1267,0.616,"dofetilide, ML133",0.735182176990464,0.210419287835575,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.47031,-1.28,0.186,1108,0.662,"clofibrate, pterostilbene, ciprofibrate, GW.501516",0.730487055782084,0.1791420105603,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.50578,-1.35,0.136,1402,0.804,"dienogest, norgestrel",0.866461091629782,0.0947439512515487,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.4017,0.992,0.462,195,0.717,"carfilzomib, bortezomib",0.335358024443874,0.1444808443322,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.46752,1.11,0.346,417,0.679,"brefeldin.a, clindamycin.phosphate, chloramphenicol.palmitate, homoharringtonine, azomycin..2.nitroimidazole., cycloheximide, bruceantin, tedizolid.phosphate",0.460923901207223,0.168130225719498,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.46669,1.13,0.294,377,0.664,"AV.412, NVP.TAE226, PP.121",0.531652669587843,0.177831920631982,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.63823,1.51,0.0622,200,0.557,"AZ.628, dabrafenib, vemurafenib, CEP.32496, LGX818, SB.590885",1.20620961530918,0.254144804826271,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.57362,1.37,0.125,406,0.751,"vandetanib, sunitinib, regorafenib, sorafenib",0.903089986991944,0.124360062995832,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",0.71117,1.7,0.0219,194,0.322,"tamibarotene, CD.437, adarotene, AM.580",1.65955588515988,0.492144128304169,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.40211,-1.11,0.309,1086,0.612,"pentostatin, fludarabine, cytarabine, hydroxyurea, clofarabine, gemcitabine",0.510041520575165,0.213248577854439,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",-0.66371,-1.84,0.0226,1447,0.323,"aripiprazole",1.6458915608526,0.490797477668897,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",-0.31928,-0.892,0.58,1447,0.748,"aripiprazole",0.236572006437063,0.126098402135539,FALSE
+"HCC15","Pearson.est","sodium channel blocker",-0.26782,-0.709,0.771,1276,0.858,"cibenzoline, lappaconite, oxcarbazepine",0.112945621949043,0.0665127121512946,FALSE
+"HCC15","Pearson.est","src inhibitor",0.64064,1.56,0.0495,105,0.627,"saracatinib, dasatinib, ZM.306416, PP.2",1.30539480106643,0.202732459169284,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",0.27717,0.669,0.855,465,0.972,"terconazole, sulconazole, lanoconazole",0.0680338852718274,0.0123337350737254,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.57039,1.37,0.15,66,0.751,"repsox, D.4476",0.823908740944319,0.124360062995832,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.53782,1.3,0.177,44,0.697,"carmofur",0.752026733638193,0.156767221901991,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",-0.63409,-1.75,0.0422,1117,0.341,"daunorubicin, epirubicin, camptothecin, rubitecan, valrubicin, amsacrine, teniposide, exatecan.mesylate, etoposide, idarubicin, nemorubicin, genz.644282, voreloxin, TAS.103, amonafide, mitoxantrone",1.37468754903833,0.467245621007502,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.23288,0.556,0.952,541,1,"nocodazole, indibulin, vindesine, vinorelbine, oxibendazole, podophyllotoxin, plinabulin, albendazole, mebendazole, vincristine, verubulin, parbendazole",0.0213630516155257,0,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.42549,1.03,0.423,406,0.736,"vandetanib, dasatinib, tivantinib, AV.412, NVP.TAE226, sunitinib, regorafenib, PP.121, sorafenib",0.373659632624958,0.133122185662501,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.33429,0.801,0.715,320,0.877,"XL.647, vandetanib, ZM.306416, PD.173074, BMS.690514, MK.2461, lucitanib, sunitinib, regorafenib, ENMD.2076",0.145693958198919,0.0570004066339595,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",-0.27967,-0.753,0.734,403,0.89,"alfacalcidol, calcitriol, tacalcitol, ercalcitriol, paricalcitol, maxacalcitol, doxercalciferol",0.134303940083929,0.0506099933550872,FALSE
diff --git a/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren/DMEA/DMEA_venn_diagram.pdf
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diff --git a/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_interactive_network.graph.html b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_interactive_network.graph.html
new file mode 100644
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--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-e5d548bb7954c49b92eb" style="width:960px;height:500px;"></div>
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diff --git a/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..ca89807
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_mean_results.csv
@@ -0,0 +1,84 @@
+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"mTOR inhibitor",1.749,0.0773168463974192,1.81770657168265e-15,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,1,"HCC827",5.02898818165532e-14
+"AP inhibitor",1.6535,0.0755523520132685,4.54471748498591e-11,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",4.71514439067288e-10
+"DNA methyltransferase inhibitor",1.568,0.164303954528442,4.91911199325153e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",4.53651439377641e-08
+"potassium channel blocker",1.5105,0.0971962204160115,2.77990508975808e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",1.92276768708267e-06
+"cytochrome P450 inhibitor",1.42335,0.138754715424852,1.86814499856125e-05,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.000103370689920389
+"vitamin D receptor agonist",1.356,0.151844796108603,0.000210101338773053,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00108990069488521
+"HSP inhibitor",1.322,0.149968417727832,0.000926496321902759,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.00452348204223112
+"HDAC inhibitor",1.166,0.0569764494284585,0.0967786388401707,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.401631351186709
+"benzodiazepine receptor agonist",1.1104,0.0654461610791649,0.262209222425643,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.946233280927322
+"ATPase inhibitor",1.10575,0.098505610313108,0.276686861938312,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.956875397536664
+"RAF inhibitor",1.0673,0.19274010316595,0.393170355853769,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"AKT inhibitor",1.06345,0.124425617179608,0.462291062814404,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"EGFR inhibitor",1.0527,0.124433072266517,0.510643799893822,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"tubulin polymerization inhibitor",1.03945,0.127331922238897,0.567924069219369,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"HCV inhibitor",1.0226,0.148299270679968,0.642672692732662,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"DNA polymerase inhibitor",1.01125,0.10167744406494,0.719223078754668,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"microtubule inhibitor",0.99945,0.0843223607729041,0.761881356671272,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"proteasome inhibitor",0.9991,0.124047910947852,0.735345838446027,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"bacterial DNA gyrase inhibitor",0.99845,0.143989208294452,0.730843891500061,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"HMGCR inhibitor",0.9921,0.172175522436599,0.756881291720326,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"glycogen synthase kinase inhibitor",0.95645,0.0786340457937574,0.897785829851299,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"PI3K inhibitor",0.94065,0.0646775605763333,0.943152705883192,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"adrenergic receptor antagonist",0.8513,0.0724780184462485,0.997692020232059,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"glutamate receptor antagonist",0.83055,0.0690975473705947,0.999126970013929,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"sodium channel blocker",0.82145,0.13733304696785,0.998915844082484,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"Aurora kinase inhibitor",0.8076,0.157815148362353,0.99929419741276,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"Bcr.Abl kinase inhibitor",0.77715,0.525378387450417,0.94424779269903,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"retinoid receptor agonist",0.75985,0.387731631958308,0.998284025469237,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"PLK inhibitor",0.7465,0.540690932243667,0.975484102506319,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"protein synthesis inhibitor",0.7229,0.079108120549297,0.999999557876575,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"topoisomerase inhibitor",0.6587,0.300590489046582,0.999999881659007,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"sterol demethylase inhibitor",0.6391,0.672213773954935,0.977773940363725,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"phosphodiesterase inhibitor",0.49995,0.480694943750575,0.999999995001786,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"tyrosine kinase inhibitor",0.4205,0.552137616331672,0.999999996706063,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"acetylcholine receptor agonist",0.40895,0.518550964353147,0.999999999849094,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"Abl kinase inhibitor",0.37755,0.738387679873841,0.99961702078595,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"VEGFR inhibitor",0.1306,0.582349180836594,0.999999999999998,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"adenosine receptor antagonist",-0.18175,0.95280096087936,0.917186682244559,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"MDM inhibitor",-0.2309,0.807614740096448,0.999364086978706,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"KIT inhibitor",-0.2856,0.775155970722905,0.999845525377226,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"protein tyrosine kinase inhibitor",-0.3517,0.788012964093198,0.998627128197425,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"thymidylate synthase inhibitor",-0.38475,0.729261694058486,0.999704979167057,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"CC chemokine receptor antagonist",-0.5173,0.450509080462256,0.999999997141223,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"CDK inhibitor",-0.56825,0.397803558371002,0.999999943267046,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"BCL inhibitor",-0.5941,0.788819097398797,0.856055565248078,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"p38 MAPK inhibitor",-0.59935,0.281905783999959,0.999999999540895,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"DNA inhibitor",-0.6392,0.0693348852727793,0.999999999971843,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"histamine receptor antagonist",-0.6692,0.0774124972910841,0.999999998631121,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"DNA synthesis inhibitor",-0.69915,0.31092955286062,0.999980156599818,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"bacterial 50S ribosomal subunit inhibitor",-0.7296,0.64428143572592,0.88420601736604,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"MEK inhibitor",-0.7445,0.11614306060336,0.999992140327109,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"PPAR receptor agonist",-0.7485,0.383463646805082,0.998646186855031,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"phosphatase inhibitor",-0.75555,0.353245922239659,0.998967731258152,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"FGFR inhibitor",-0.7957,0.169341790782025,0.999560383339883,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"estrogen receptor agonist",-0.8011,0.336723672436239,0.995423765507422,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"DNA alkylating agent",-0.85255,0.126899659905811,0.995109343422822,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"ALK tyrosine kinase receptor inhibitor",-0.89135,0.160093812957804,0.975707463200835,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"RET tyrosine kinase inhibitor",-0.90055,0.436464199412072,0.788218544040761,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"calcium channel blocker",-0.9185,0.0999376121177081,0.952838069351939,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"PDGFR tyrosine kinase receptor inhibitor",-0.9307,0.160510403007669,0.923144648720296,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"src inhibitor",-0.93535,0.18186758485517,0.914419006996309,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"FLT3 inhibitor",-0.945,0.0965810267953396,0.916365472930537,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"JAK inhibitor",-0.9644,0.112318813159122,0.853814317801295,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"glucocorticoid receptor agonist",-0.96475,0.14640170943782,0.853809512985718,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"dopamine receptor antagonist",-0.97,0.0769059576092092,0.855963497237929,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"ribonucleotide reductase inhibitor",-0.9703,0.0602469479462828,0.847431868676047,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"cyclooxygenase inhibitor",-1.01165,0.0935016324090542,0.682258748045896,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"adrenergic receptor agonist",-1.04165,0.0581715023375753,0.563684692077703,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"serotonin receptor antagonist",-1.043,0.453502161545362,0.179402530951814,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.709067146142885
+"NFkB pathway inhibitor",-1.0561,0.0797086140758622,0.486194204375438,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.999999999999998
+"opioid receptor agonist",-1.1162,0.0597922719878889,0.245329067947084,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.925559665436727
+"bromodomain inhibitor",-1.1776,0.228974694074074,0.0539383000035225,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.235625205278546
+"CHK inhibitor",-1.1927,0.212135036437196,0.0356117705564163,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",0.164209830899031
+"TGF beta receptor inhibitor",-1.465,0.155817031701997,6.26067247011913e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",3.7116843929992e-05
+"PARP inhibitor",-1.472,0.0869119336485291,3.82990686108232e-06,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,0,"",2.44524822669102e-05
+"growth factor receptor inhibitor",-1.5185,0.135734842131345,1.66808731112601e-07,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,2,"HCC4006, H460",1.25864769839508e-06
+"antioxidant",-1.59,0.14682606967716,7.00979812697237e-09,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,3,"HCC4006, HCC2279, HCC44",5.81813244538707e-08
+"progesterone receptor agonist",-1.6565,0.210694965343391,4.48035671584148e-12,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,8,"H358, H3255, H1648, H2126, HCC2279, H520, HCC15, HCC44",6.19782679024738e-11
+"MET inhibitor",-1.7265,0.218180876194139,1.33276086328534e-11,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,10,"H358, HCC95, HCC78, CALU3, H2009, HCC2279, H460, A549, H1703, H1299",1.58027359503833e-10
+"serotonin receptor agonist",-1.7526,0.22556231488158,3.81555527937888e-15,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,14,"H358, H1650, H1648, HCC78, H2126, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44",7.91727720471117e-14
+"androgen receptor antagonist",-1.9005,0.0845716762341425,2.06191825891495e-19,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,18,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, CALU3, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",8.55696077449703e-18
+"acetylcholine receptor antagonist",-1.936,0.0916170519637382,1.00447673629914e-20,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,19,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",8.33715691128287e-19
+"estrogen receptor antagonist",-2.1135,0.0883935577552549,9.28727143852532e-15,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",20,20,"H358, H1650, HCC95, H3255, H1648, H1975, HCC78, H2126, HCC827, CALU3, H2009, HCC4006, HCC2279, H520, HCC15, H460, A549, HCC44, H1703, H1299",1.5416870587952e-13
diff --git a/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..6cee985
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_results.csv
@@ -0,0 +1,1661 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H358","Pearson.est","EGFR inhibitor",0.40339,1.02,0.442,307,0.857,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, BMS.690514, WZ.3146, brigatinib, XL.647, canertinib, PD.168393, gefitinib, BIBU.1361, BIBX.1382, AST.1306, icotinib, AZD8931, pelitinib",0.354577730650908,0.0670191780768018,FALSE
+"H358","Pearson.est","Abl kinase inhibitor",-0.21057,-0.566,0.956,1181,0.985,"imatinib, KW.2449, flumatinib",0.0195421077238999,0.00656376950238827,FALSE
+"H358","Pearson.est","acetylcholine receptor agonist",0.18207,0.473,0.996,165,0.986,"xanomeline",0.00174066157630127,0.0061230850587888,FALSE
+"H358","Pearson.est","acetylcholine receptor antagonist",-0.76326,-1.95,0.00607,1322,0.152,"iododexetimide, dicycloverine, methscopolamine",2.21681130892474,0.818156412055227,TRUE
+"H358","Pearson.est","adenosine receptor antagonist",-0.38629,-0.986,0.437,1428,1,"istradefylline",0.359518563029578,0,FALSE
+"H358","Pearson.est","adrenergic receptor agonist",-0.41,-1.07,0.367,1052,1,"clenbuterol, xylazine, ritodrine, midodrine, methyldopa, oxymetazoline, norepinephrine, isoetharine",0.435333935747911,0,FALSE
+"H358","Pearson.est","adrenergic receptor antagonist",0.33404,0.858,0.633,188,0.858,"practolol, propranolol, idazoxan, vincamine",0.198596289982645,0.0665127121512946,FALSE
+"H358","Pearson.est","AKT inhibitor",0.38861,1.01,0.427,366,0.833,"MK.2206, triciribine, ONC201, AT7867, palomid.529",0.369572124974976,0.0793549985932124,FALSE
+"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33107,-0.908,0.533,1231,0.899,"alectinib, CEP.37440, DMH1",0.273272790973428,0.0462403082667712,FALSE
+"H358","Pearson.est","androgen receptor antagonist",-0.71669,-1.85,0.00828,1055,0.218,"bicalutamide, nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.08196966321512,0.661543506395395,TRUE
+"H358","Pearson.est","antioxidant",-0.64627,-1.66,0.0363,1200,0.301,"benfotiamine, trolox",1.44009337496389,0.521433504406157,FALSE
+"H358","Pearson.est","AP inhibitor",0.68798,1.77,0.0252,59,0.732,"birinapant, GDC.0152",1.59859945921846,0.135488918941608,FALSE
+"H358","Pearson.est","ATPase inhibitor",0.41834,1.07,0.383,289,0.983,"k.strophanthidin, oligomycin.a, evodiamine, blebbistatin...., ouabain",0.416801226031377,0.00744648216786438,FALSE
+"H358","Pearson.est","Aurora kinase inhibitor",0.31149,0.801,0.693,564,0.89,"MK.5108, barasertib.HQPA, MK.8745, ENMD.2076, barasertib, alisertib, PF.03814735, ZM.447439, MLN.8054, CCT137690, SNS.314, AMG900, danusertib",0.159266765388193,0.0506099933550872,FALSE
+"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.39566,-1.03,0.386,1359,1,"azalomycin.b, dirithromycin",0.413412695328245,0,FALSE
+"H358","Pearson.est","bacterial DNA gyrase inhibitor",0.48743,1.27,0.211,144,1,"lomefloxacin, novobiocin, finafloxacin",0.675717544702307,0,FALSE
+"H358","Pearson.est","BCL inhibitor",-0.34022,-0.88,0.556,1385,0.841,"gossypol, ABT.737",0.254925208417942,0.0752040042020878,FALSE
+"H358","Pearson.est","Bcr.Abl kinase inhibitor",0.26067,0.679,0.824,304,0.948,"dasatinib, metatinib, bafetinib",0.0840727883028842,0.0231916626619338,FALSE
+"H358","Pearson.est","benzodiazepine receptor agonist",0.41764,1.07,0.379,141,0.983,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.421360790031928,0.00744648216786438,FALSE
+"H358","Pearson.est","bromodomain inhibitor",-0.62006,-1.56,0.0789,982,0.379,"bromosporine, JQ1...., I.BET151, PFI.1",1.10292299679058,0.421360790031928,FALSE
+"H358","Pearson.est","calcium channel blocker",-0.38051,-1.02,0.407,1224,1,"efonidipine.monoethanolate, SR.33805, mibefradil",0.39040559077478,0,FALSE
+"H358","Pearson.est","CC chemokine receptor antagonist",-0.20402,-0.544,0.972,294,0.958,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.0123337350737254,0.0186344909214556,FALSE
+"H358","Pearson.est","CDK inhibitor",-0.32523,-0.867,0.597,941,0.841,"BMS.387032, palbociclib, PHA.848125, arcyriaflavin.a, R547, indirubin, AZD5438, abemaciclib, ribociclib, BMS.265246, JNJ.7706621, TG.02",0.224025668870631,0.0752040042020878,FALSE
+"H358","Pearson.est","CHK inhibitor",-0.37743,-0.983,0.435,1083,1,"SCH.900776, AZD7762, SB.218078",0.361510743045363,0,FALSE
+"H358","Pearson.est","cyclooxygenase inhibitor",-0.342,-0.891,0.58,1247,0.875,"acetylsalicylsalicylic.acid, FR.122047, piroxicam, tryptanthrin, naproxen",0.236572006437063,0.0579919469776868,FALSE
+"H358","Pearson.est","cytochrome P450 inhibitor",0.6093,1.55,0.069,254,0.816,"PF.4981517, eplerenone, morin",1.16115090926274,0.0883098412461389,FALSE
+"H358","Pearson.est","DNA alkylating agent",-0.28961,-0.753,0.739,1027,0.92,"TH.302, streptozotocin, carmustine, cyclophosphamide, melphalan, satraplatin, temozolomide",0.131355561605174,0.0362121726544447,FALSE
+"H358","Pearson.est","DNA inhibitor",-0.21882,-0.582,0.942,1062,1,"primaquine, carmustine, melphalan, busulfan, nithiamide, pibenzimol",0.0259490972071227,0,FALSE
+"H358","Pearson.est","DNA methyltransferase inhibitor",0.54864,1.42,0.125,485,0.832,"decitabine, azacitidine, SGI.1027, fdcyd",0.903089986991944,0.0798766737092761,FALSE
+"H358","Pearson.est","DNA polymerase inhibitor",0.37945,0.982,0.469,138,0.848,"cephalomannine, foscarnet, cidofovir",0.328827157284917,0.0716041477432862,FALSE
+"H358","Pearson.est","DNA synthesis inhibitor",-0.22121,-0.578,0.94,1245,0.998,"altretamine, enocitabine",0.0268721464003014,0.000869458712628891,FALSE
+"H358","Pearson.est","dopamine receptor antagonist",-0.36009,-0.944,0.489,1101,0.958,"mesoridazine, nemonapride, remoxipride, ziprasidone, paliperidone, amisulpride, lurasidone",0.31069114087638,0.0186344909214556,FALSE
+"H358","Pearson.est","estrogen receptor agonist",-0.33575,-0.846,0.609,1195,0.856,"estrone, erteberel",0.215382707367125,0.0675262353228468,FALSE
+"H358","Pearson.est","estrogen receptor antagonist",-0.80158,-2.07,0.00211,1257,0.0962,"danazol, raloxifene, fulvestrant, tamoxifen",2.67571754470231,1.01682492796219,TRUE
+"H358","Pearson.est","FGFR inhibitor",-0.29795,-0.771,0.761,1010,0.915,"nintedanib, MK.2461, lenvatinib, lucitanib",0.118615343229427,0.0385789059335517,FALSE
+"H358","Pearson.est","FLT3 inhibitor",-0.35743,-0.929,0.521,1128,0.921,"TG.101348, quizartinib, KW.2449, pacritinib, TG.02, sunitinib, lestaurtinib",0.283162276700476,0.0357403698031511,FALSE
+"H358","Pearson.est","glucocorticoid receptor agonist",-0.37382,-0.972,0.488,906,0.972,"fludroxycortide, triamcinolone, desonide, clobetasol.propionate, triamcinolone.acetonide, halcinonide, prednisolone, halobetasol.propionate, prednisolone.acetate, flumethasone, rimexolone, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, piretanide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.311580177997289,0.0123337350737254,FALSE
+"H358","Pearson.est","glutamate receptor antagonist",0.32873,0.828,0.645,195,0.878,"ACDPP, tiletamine, kynurenic.acid",0.190440285364732,0.0565054840938974,FALSE
+"H358","Pearson.est","glycogen synthase kinase inhibitor",0.35703,0.958,0.479,53,0.854,"CHIR.99021",0.319664486585437,0.068542129310995,FALSE
+"H358","Pearson.est","growth factor receptor inhibitor",-0.60071,-1.54,0.085,1216,0.371,"GSK1838705A, GW.441756, lestaurtinib",1.07058107428571,0.430626090384954,FALSE
+"H358","Pearson.est","HCV inhibitor",0.35051,0.891,0.568,100,0.868,"daclatasvir",0.245651664288981,0.0614802748235081,FALSE
+"H358","Pearson.est","HDAC inhibitor",0.45829,1.18,0.278,401,1,"chidamide, nexturastat.a, panobinostat, NSC.3852, belinostat, SB.939, scriptaid, entinostat, ACY.1215, M.344, mocetinostat, romidepsin, resminostat, givinostat",0.555955204081924,0,FALSE
+"H358","Pearson.est","histamine receptor antagonist",-0.27476,-0.72,0.799,1137,0.947,"terfenadine, tiotidine, ranitidine, BF2.649, ebastine, epinastine",0.0974532206860086,0.0236500209967266,FALSE
+"H358","Pearson.est","HMGCR inhibitor",0.39822,1.02,0.42,202,0.857,"atorvastatin, simvastatin",0.3767507096021,0.0670191780768018,FALSE
+"H358","Pearson.est","HSP inhibitor",0.47046,1.22,0.226,283,1,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, ganetespib, SNX.5422",0.645891560852599,0,FALSE
+"H358","Pearson.est","JAK inhibitor",-0.38869,-1,0.438,1128,1,"TG.101348, CEP.33779, AZD1480, pacritinib, filgotinib, TG.02, lestaurtinib",0.3585258894959,0,FALSE
+"H358","Pearson.est","KIT inhibitor",-0.33479,-0.885,0.552,1181,0.858,"imatinib, lenvatinib, vatalanib, telatinib, sunitinib, masitinib",0.258060922270801,0.0665127121512946,FALSE
+"H358","Pearson.est","MDM inhibitor",0.22816,0.59,0.915,1119,0.983,"serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3, RITA",0.0385789059335517,0.00744648216786438,FALSE
+"H358","Pearson.est","MEK inhibitor",-0.2082,-0.544,0.947,1199,0.958,"MEK162, BIX.02188, nobiletin, arctigenin",0.0236500209967266,0.0186344909214556,FALSE
+"H358","Pearson.est","MET inhibitor",-0.67837,-1.79,0.0185,1172,0.242,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.73282827159699,0.616184634019569,TRUE
+"H358","Pearson.est","microtubule inhibitor",0.42673,1.1,0.345,389,1,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel",0.462180904926726,0,FALSE
+"H358","Pearson.est","mTOR inhibitor",0.66482,1.72,0.0214,332,0.5,"deforolimus, PI.103, PKI.179, AZD8055, torin.1, everolimus, temsirolimus, NVP.BEZ235, LY3023414, PP242, MLN0128, sirolimus, SB.2343, AZD2014, GDC.0980, torin.2, WYE.125132, PF.04691502, voxtalisib",1.66958622665081,0.301029995663981,FALSE
+"H358","Pearson.est","NFkB pathway inhibitor",-0.40209,-1.05,0.392,1206,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.406713932979543,0,FALSE
+"H358","Pearson.est","opioid receptor agonist",-0.41881,-1.1,0.337,1241,1,"ADL5859, salvinorin.a",0.472370099128661,0,FALSE
+"H358","Pearson.est","p38 MAPK inhibitor",-0.3008,-0.789,0.73,1326,0.91,"skepinone.l",0.136677139879544,0.0409586076789064,FALSE
+"H358","Pearson.est","PARP inhibitor",-0.60063,-1.59,0.0618,1024,0.375,"olaparib, niraparib, AZD2461, AG.14361, talazoparib",1.20901152491118,0.425968732272281,FALSE
+"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37863,-0.98,0.454,1008,0.996,"motesanib, nintedanib, crenolanib, KI.8751, axitinib, imatinib, lenvatinib, vatalanib, telatinib, sunitinib, CP.673451, masitinib",0.342944147142896,0.00174066157630127,FALSE
+"H358","Pearson.est","phosphatase inhibitor",-0.34704,-0.907,0.547,1222,0.871,"CID.5458317, menadione, alexidine",0.262012673666569,0.0599818449923368,FALSE
+"H358","Pearson.est","phosphodiesterase inhibitor",-0.22847,-0.6,0.926,1198,1,"trequinsin, GSK256066, avanafil",0.0333890133180656,0,FALSE
+"H358","Pearson.est","PI3K inhibitor",0.35841,0.948,0.487,332,0.833,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, SB.2343, GDC.0980, ZSTK.474, PF.04691502, voxtalisib",0.312471038785366,0.0793549985932124,FALSE
+"H358","Pearson.est","PLK inhibitor",0.34282,0.91,0.572,954,0.869,"HMN.214, BI.2536, volasertib, GSK461364, rigosertib, NMS.1286937, GW.843682X",0.242603971206976,0.0609802235513335,FALSE
+"H358","Pearson.est","potassium channel blocker",0.59895,1.53,0.0732,458,0.667,"ibutilide, ML133, mepivacaine, dofetilide, oleoylethanolamide",1.13548891894161,0.175874166083451,FALSE
+"H358","Pearson.est","PPAR receptor agonist",-0.30572,-0.804,0.658,1071,0.908,"clofibrate, S26948, fenofibrate",0.181774106386044,0.0419141514789149,FALSE
+"H358","Pearson.est","progesterone receptor agonist",-0.65161,-1.72,0.0246,1130,0.247,"norgestrel, dienogest, melengestrol.acetate, danazol, nomegestrol.acetate, norethindrone.acetate",1.60906489289662,0.607303046740334,TRUE
+"H358","Pearson.est","proteasome inhibitor",0.33719,0.876,0.597,193,0.859,"ONX.0914, MG.132",0.224025668870631,0.0660068361687577,FALSE
+"H358","Pearson.est","protein synthesis inhibitor",0.27276,0.709,0.804,502,0.939,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, chloramphenicol.palmitate, azomycin..2.nitroimidazole.",0.0947439512515487,0.0273344077338891,FALSE
+"H358","Pearson.est","protein tyrosine kinase inhibitor",-0.25486,-0.65,0.889,1313,0.993,"CP.724714, rheochrysidin",0.0510982390297863,0.00305075150461883,FALSE
+"H358","Pearson.est","RAF inhibitor",0.40646,1.05,0.39,427,0.964,"SB.590885, vemurafenib, LGX818, dabrafenib, AZ.628, sorafenib",0.408935392973501,0.0159229660971692,FALSE
+"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.3524,-0.933,0.537,1374,0.946,"sunitinib",0.270025714300444,0.0241088635982073,FALSE
+"H358","Pearson.est","retinoid receptor agonist",0.40115,1.03,0.429,42,0.947,"LE.135",0.367542707815276,0.0236500209967266,FALSE
+"H358","Pearson.est","ribonucleotide reductase inhibitor",-0.3761,-0.967,0.459,1440,0.943,"pentostatin",0.338187314462739,0.0254883072626717,FALSE
+"H358","Pearson.est","serotonin receptor agonist",-0.68992,-1.76,0.0292,1335,0.239,"zolmitriptan, ipsapirone, aripiprazole",1.53461714855158,0.621602099051862,TRUE
+"H358","Pearson.est","serotonin receptor antagonist",-0.48188,-1.29,0.176,1177,0.754,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.75448733218585,0.122628654130226,FALSE
+"H358","Pearson.est","sodium channel blocker",0.29636,0.785,0.71,450,0.853,"brivaracetam, ajmaline, cibenzoline, mexiletine, mepivacaine, butamben",0.148741651280925,0.069050968832477,FALSE
+"H358","Pearson.est","src inhibitor",-0.39258,-1.02,0.406,999,1,"TG.100572, bosutinib, PP.1, PP.2, masitinib",0.391473966422806,0,FALSE
+"H358","Pearson.est","sterol demethylase inhibitor",-0.35247,-0.909,0.55,1184,0.929,"sulconazole, posaconazole, ketoconazole",0.259637310505756,0.0319842860063582,FALSE
+"H358","Pearson.est","TGF beta receptor inhibitor",-0.57122,-1.49,0.092,964,0.412,"repsox, adaprev, SB.525334, SB.431542, D.4476",1.03621217265444,0.385102783966865,FALSE
+"H358","Pearson.est","thymidylate synthase inhibitor",-0.24896,-0.657,0.86,359,1,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.0655015487564323,0,FALSE
+"H358","Pearson.est","topoisomerase inhibitor",0.30593,0.798,0.669,517,0.864,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin, amsacrine, epirubicin, voreloxin, rubitecan, camptothecin, etoposide, teniposide, daunorubicin, valrubicin",0.174573882232177,0.0634862575211067,FALSE
+"H358","Pearson.est","tubulin polymerization inhibitor",0.40809,1.09,0.352,400,1,"mebendazole, epothilone.b, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, indibulin, taltobulin, verubulin, podophyllotoxin, dolastatin.10",0.453457336521869,0,FALSE
+"H358","Pearson.est","tyrosine kinase inhibitor",0.23553,0.626,0.895,427,0.98,"dasatinib, AV.412, NVP.TAE226, bafetinib, vandetanib, mubritinib, tyrphostin.A9, GTP.14564, apatinib, sorafenib",0.048176964684088,0.00877392430750515,FALSE
+"H358","Pearson.est","VEGFR inhibitor",0.19918,0.508,0.963,111,1,"BMS.690514, SAR131675, OSI.930, XL.647",0.0163737128754655,0,FALSE
+"H358","Pearson.est","vitamin D receptor agonist",0.5404,1.38,0.116,333,0.808,"ercalcitriol, calcitriol, maxacalcitol",0.935542010773082,0.0925886392254138,FALSE
+"H1650","Pearson.est","EGFR inhibitor",0.43737,1.13,0.312,335,0.784,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, canertinib, WZ.3146, gefitinib, AST.1306, brigatinib, PD.168393, icotinib, BIBU.1361, BIBX.1382, afatinib, pelitinib, osimertinib, AZD8931, lapatinib",0.505845405981557,0.105683937315562,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",0.40855,1.04,0.386,148,0.888,"dasatinib, metatinib, bafetinib",0.413412695328245,0.051587034221399,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.29338,0.765,0.743,83,0.876,"xanomeline",0.129011186239425,0.0574958938319193,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.72074,-1.84,0.0103,1171,0.236,"hyoscyamine, dicycloverine, iododexetimide, methscopolamine",1.98716277529483,0.627087997029893,TRUE
+"H1650","Pearson.est","adenosine receptor antagonist",0.34334,0.907,0.556,165,0.905,"theophylline, PSB.1115",0.254925208417942,0.0433514207947967,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.45937,-1.21,0.246,1117,0.908,"lidamidine, xylazine, oxymetazoline, ritodrine, methyldopa, norepinephrine, isoetharine",0.609064892896621,0.0419141514789149,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.29626,0.76,0.737,198,0.858,"practolol, vincamine, idazoxan, propranolol",0.132532512140949,0.0665127121512946,FALSE
+"H1650","Pearson.est","AKT inhibitor",0.49716,1.28,0.188,409,0.919,"MK.2206, triciribine, palomid.529, AT7867, ONC201, GSK2110183",0.72584215073632,0.0366844886138887,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.32233,-0.846,0.633,1213,0.905,"alectinib, CEP.37440, DMH1",0.198596289982645,0.0433514207947967,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.70446,-1.82,0.0257,1184,0.203,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.59006687666871,0.692503962086787,TRUE
+"H1650","Pearson.est","antioxidant",-0.5841,-1.5,0.0803,1035,0.571,"benfotiamine, trolox",1.09528445472132,0.243363891754152,FALSE
+"H1650","Pearson.est","AP inhibitor",0.63194,1.64,0.0552,111,0.561,"birinapant, GDC.0152",1.2580609222708,0.251037138743839,FALSE
+"H1650","Pearson.est","ATPase inhibitor",0.39742,1.03,0.425,383,0.861,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.371611069949688,0.0649968485463452,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.40718,1.04,0.402,548,0.888,"barasertib.HQPA, MK.8745, alisertib, barasertib, MK.5108, ZM.447439, PF.03814735, CCT137690, SNS.314, danusertib, hesperadin, ENMD.2076, AMG900, MLN.8054",0.39577394691553,0.051587034221399,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.38269,-0.997,0.408,1333,0.893,"azalomycin.b, dirithromycin",0.38933983691012,0.0491485411114536,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",0.31532,0.796,0.694,370,0.881,"lomefloxacin, novobiocin, trovafloxacin, finafloxacin",0.158640529545145,0.0550240915879521,FALSE
+"H1650","Pearson.est","BCL inhibitor",-0.36829,-0.966,0.463,1386,0.885,"gossypol, ABT.737",0.334419008982047,0.0530567293021746,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.4627,1.2,0.244,148,0.864,"dasatinib, metatinib, bafetinib",0.612610173661271,0.0634862575211067,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",0.46156,1.19,0.265,100,0.815,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.576754126063192,0.0888423912600234,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",-0.32216,-0.825,0.646,1096,0.889,"I.BET151, PFI.1",0.189767482004916,0.0510982390297863,FALSE
+"H1650","Pearson.est","calcium channel blocker",-0.39734,-1.03,0.376,1295,0.899,"SR.33805, efonidipine.monoethanolate, mibefradil",0.424812155072339,0.0462403082667712,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",-0.29493,-0.761,0.74,425,0.897,"MK.0812, UNBS.5162, ZK811752, RS.504393, SB.225002, navarixin, PF.04136309",0.130768280269024,0.0472075569559079,FALSE
+"H1650","Pearson.est","CDK inhibitor",-0.23834,-0.622,0.886,1044,0.943,"abemaciclib, R547, indirubin, AZD5438, JNJ.7706621, ribociclib, BMS.265246, TG.02",0.0525662781129492,0.0254883072626717,FALSE
+"H1650","Pearson.est","CHK inhibitor",-0.49408,-1.29,0.175,1148,0.77,"AZD7762, SCH.900776, SB.218078",0.756961951313706,0.113509274827518,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",-0.42845,-1.1,0.328,1258,0.878,"AM.404, acetylsalicylsalicylic.acid, piroxicam, tryptanthrin, FR.122047, naproxen",0.484126156288321,0.0565054840938974,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",0.61218,1.57,0.0545,196,0.594,"PF.4981517, morin, eplerenone",1.26360349772336,0.226213555018806,FALSE
+"H1650","Pearson.est","DNA alkylating agent",-0.2796,-0.739,0.788,984,0.907,"melphalan, carmustine, mitomycin.c, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.103473782510445,0.0423927129399047,FALSE
+"H1650","Pearson.est","DNA inhibitor",-0.32429,-0.847,0.638,1207,0.933,"metronidazole, busulfan, pibenzimol, nithiamide",0.195179321278838,0.0301183562535,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.66448,1.75,0.0236,483,0.867,"SGI.1027, azacitidine, decitabine, fdcyd, RG108",1.62708799702989,0.0619809025237897,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",0.36339,0.92,0.55,294,0.92,"cephalomannine, foscarnet, cidofovir, idoxuridine",0.259637310505756,0.0362121726544447,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",-0.3417,-0.903,0.569,1194,0.916,"artesunate, CB.10.277, altretamine, enocitabine",0.244887733604929,0.0381045263321496,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",-0.4203,-1.1,0.321,1178,0.878,"paliperidone, mesoridazine, ziprasidone, remoxipride, amisulpride, lurasidone",0.493494967595128,0.0565054840938974,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",-0.37134,-0.973,0.483,1301,0.909,"estrone, erteberel",0.316052869248488,0.0414361167780325,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",-0.83737,-2.2,0,1321,0.0169,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.77211329538633,TRUE
+"H1650","Pearson.est","FGFR inhibitor",-0.21921,-0.566,0.945,1002,0.946,"nintedanib, lucitanib, MK.2461, lenvatinib",0.0245681914907371,0.0241088635982073,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",-0.31526,-0.833,0.628,1132,0.902,"TG.101348, pacritinib, quizartinib, TG.02, sunitinib, lestaurtinib",0.202040356262804,0.0447934624580583,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",-0.39485,-1.04,0.393,962,0.92,"flumethasone, ciclesonide, fludroxycortide, halcinonide, desonide, prednisolone, triamcinolone.acetonide, triamcinolone, rimexolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, piretanide, fluocinolone.acetonide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.405607449624573,0.0362121726544447,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",0.30263,0.756,0.737,257,0.838,"ACDPP, tiletamine, kynurenic.acid",0.132532512140949,0.0767559813697235,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.39659,1.02,0.42,39,0.837,"CHIR.99021",0.3767507096021,0.07727454200674,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",-0.58184,-1.49,0.0884,1388,0.521,"GW.441756, lestaurtinib",1.05354773498693,0.283162276700476,FALSE
+"H1650","Pearson.est","HCV inhibitor",0.32453,0.831,0.673,90,0.914,"daclatasvir",0.171984935776023,0.0390538042661686,FALSE
+"H1650","Pearson.est","HDAC inhibitor",0.4572,1.18,0.248,384,0.777,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, resminostat, M.344, entinostat, givinostat, mocetinostat",0.605548319173784,0.109578981199086,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",-0.23456,-0.609,0.93,1015,0.934,"cyproheptadine, terfenadine, lafutidine, tiotidine, ICI.162846, ranitidine, ebastine, BF2.649, epinastine",0.0315170514460649,0.0296531237699066,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",0.29737,0.752,0.759,270,0.82,"atorvastatin, simvastatin",0.11975822410452,0.0861861476162833,FALSE
+"H1650","Pearson.est","HSP inhibitor",0.56969,1.48,0.094,235,0.707,"BIIB021, PU.H71, NMS.E973, SNX.5422, NVP.AUY922, SNX.2112, ganetespib",1.0268721464003,0.150580586203101,FALSE
+"H1650","Pearson.est","JAK inhibitor",-0.42393,-1.11,0.3,1132,0.968,"TG.101348, pacritinib, CEP.33779, AZD1480, filgotinib, TG.02, lestaurtinib",0.522878745280338,0.0141246426916063,FALSE
+"H1650","Pearson.est","KIT inhibitor",-0.25608,-0.648,0.858,1128,0.937,"imatinib, lenvatinib, vatalanib, telatinib, sunitinib, masitinib",0.0665127121512946,0.0282604091122217,FALSE
+"H1650","Pearson.est","MDM inhibitor",-0.30991,-0.813,0.693,1071,0.884,"CGM097, nutlin.3, RITA",0.159266765388193,0.0535477349869269,FALSE
+"H1650","Pearson.est","MEK inhibitor",-0.31401,-0.812,0.661,1070,0.861,"PD.0325901, nobiletin, PD.318088, BIX.02188, refametinib, MEK162, arctigenin",0.17979854051436,0.0649968485463452,FALSE
+"H1650","Pearson.est","MET inhibitor",-0.61558,-1.6,0.0485,1043,0.443,"PF.04217903, INC.280, PHA.665752, NVP.BVU972, AMG458",1.31425826139774,0.35359627377693,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.39046,1,0.431,488,0.836,"estramustine.phosphate, triclabendazole, cabazitaxel, D.64131, podophyllotoxin",0.365522729839268,0.0777937225609836,FALSE
+"H1650","Pearson.est","mTOR inhibitor",0.65427,1.69,0.0245,293,0.637,"deforolimus, PI.103, AZD8055, PKI.179, temsirolimus, everolimus, torin.1, LY3023414, NVP.BEZ235, MLN0128, AZD2014, PP242, GDC.0980, WYE.125132, sirolimus, torin.2, SB.2343, palomid.529",1.61083391563547,0.19586056766465,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",-0.43556,-1.14,0.289,1229,0.951,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.539102157243452,0.0218194830625861,FALSE
+"H1650","Pearson.est","opioid receptor agonist",-0.38983,-1.05,0.361,1231,0.946,"ADL5859, salvinorin.a",0.442492798094342,0.0241088635982073,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",-0.25013,-0.655,0.878,939,0.952,"SB.242235, CMPD.1, TAK.715, skepinone.l",0.0565054840938974,0.0213630516155257,FALSE
+"H1650","Pearson.est","PARP inhibitor",-0.53469,-1.4,0.142,937,0.65,"PJ.34, niraparib, AZD2461, olaparib, AG.14361, talazoparib",0.847711655616944,0.187086643357144,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30689,-0.797,0.696,945,0.862,"crenolanib, motesanib, ponatinib, nintedanib, linifanib, KI.8751, imatinib, axitinib, lenvatinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.157390760389438,0.0644927341752872,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",-0.27988,-0.72,0.779,1118,0.912,"CID.5458317, menadione, alexidine",0.108462542327436,0.0400051616715838,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",0.32026,0.83,0.631,124,0.883,"papaverine, enoximone",0.199970640755866,0.0540392964224314,FALSE
+"H1650","Pearson.est","PI3K inhibitor",0.33419,0.858,0.63,75,0.897,"PI.103, PKI.179, BGT226, LY3023414, NVP.BEZ235",0.200659450546418,0.0472075569559079,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.36364,0.936,0.524,924,0.929,"HMN.214, BI.2536, volasertib, NMS.1286937, GSK461364, rigosertib, GW.843682X",0.280668713016273,0.0319842860063582,FALSE
+"H1650","Pearson.est","potassium channel blocker",0.51775,1.32,0.181,460,1,"ibutilide, ML133, dofetilide, mepivacaine, oleoylethanolamide",0.742321425130815,0,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",-0.32692,-0.852,0.634,1069,0.955,"S26948, clofibrate, fenofibrate",0.197910742118267,0.0199966284162537,FALSE
+"H1650","Pearson.est","progesterone receptor agonist",-0.62857,-1.62,0.0482,1125,0.486,"norgestrel, dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.31695296176115,0.313363730737707,FALSE
+"H1650","Pearson.est","proteasome inhibitor",0.48962,1.28,0.165,391,0.919,"ONX.0914, MG.132, delanzomib, carfilzomib",0.782516055786094,0.0366844886138887,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.29468,0.769,0.739,511,0.897,"clofoctol, cycloheximide, puromycin, thiostrepton, brefeldin.a, azomycin..2.nitroimidazole., methacycline, chloramphenicol.palmitate, anguidine, homoharringtonine",0.131355561605174,0.0472075569559079,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.3377,0.885,0.584,359,0.912,"AV.412, NVP.TAE226, mubritinib, tyrphostin.A9, PP.121",0.233587152887601,0.0400051616715838,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.45185,1.16,0.288,510,0.767,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628, regorafenib, PLX.4720",0.540607512240769,0.115204636051019,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.36016,-0.931,0.522,1380,0.891,"sunitinib",0.282329496997738,0.0501222959631252,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.32134,0.828,0.655,68,0.857,"LE.135",0.183758700008217,0.0670191780768018,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",-0.38685,-0.999,0.446,1440,0.931,"pentostatin",0.350665141287858,0.0310503190186574,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",-0.72827,-1.91,0.00416,1252,0.203,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",2.38090666937326,0.692503962086787,TRUE
+"H1650","Pearson.est","serotonin receptor antagonist",-0.44543,-1.17,0.262,1306,0.943,"ziprasidone, lurasidone, aripiprazole",0.581698708680255,0.0254883072626717,FALSE
+"H1650","Pearson.est","sodium channel blocker",0.34018,0.878,0.593,425,0.888,"brivaracetam, butamben, ajmaline, cibenzoline, mexiletine, mepivacaine",0.226945306635737,0.051587034221399,FALSE
+"H1650","Pearson.est","src inhibitor",-0.26593,-0.696,0.804,1415,0.922,"masitinib",0.0947439512515487,0.0352690789463706,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",-0.36614,-0.95,0.522,1237,0.884,"sulconazole, posaconazole, ketoconazole",0.282329496997738,0.0535477349869269,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.5475,-1.39,0.135,971,0.607,"repsox, SB.431542, adaprev, SB.525334, D.4476",0.869666231504994,0.216811308924742,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",-0.32802,-0.853,0.609,473,0.987,"doxifluridine, ftorafur, raltitrexed, carmofur, capecitabine, trifluridine",0.215382707367125,0.00568284733036327,FALSE
+"H1650","Pearson.est","topoisomerase inhibitor",0.23345,0.604,0.918,169,0.942,"mitoxantrone, exatecan.mesylate, idarubicin, doxorubicin",0.0371573187987575,0.0259490972071227,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.46271,1.21,0.248,488,0.923,"epothilone.b, oxibendazole, mebendazole, BNC105, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, dolastatin.10, parbendazole, plinabulin, combretastatin.A.4, KX2.391, podophyllotoxin",0.605548319173784,0.0347982989740879,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.27847,0.724,0.78,449,0.833,"AV.412, dasatinib, bafetinib, NVP.TAE226, sorafenib, mubritinib, tyrphostin.A9, PP.121, tivantinib, aminopurvalanol.a, vandetanib",0.10790539730952,0.0793549985932124,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.21312,0.534,0.952,106,0.965,"BMS.690514, XL.647, SAR131675, OSI.930",0.0213630516155257,0.0154726866562074,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",0.48954,1.27,0.197,586,0.843,"calcitriol, ercalcitriol, maxacalcitol, tacalcitol, doxercalciferol",0.705533773838407,0.0741724253752577,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",0.39045,1.02,0.417,296,0.908,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, BMS.690514, WZ.3146, XL.647, AST.1306, canertinib, gefitinib, icotinib, BIBU.1361, brigatinib, BIBX.1382, PD.168393",0.379863945026242,0.0419141514789149,FALSE
+"HCC95","Pearson.est","Abl kinase inhibitor",-0.27286,-0.695,0.829,1174,0.968,"ponatinib, KW.2449, imatinib, flumatinib",0.0814454694497265,0.0141246426916063,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.29493,0.777,0.73,325,0.916,"xanomeline, oxiracetam",0.136677139879544,0.0381045263321496,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.70559,-1.91,0.0164,1313,0.217,"dicycloverine, methscopolamine, iododexetimide",1.7851561519523,0.66354026615147,TRUE
+"HCC95","Pearson.est","adenosine receptor antagonist",0.31168,0.809,0.677,172,0.962,"theophylline, PSB.1115",0.169411331314856,0.0168249279621871,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",-0.3712,-0.979,0.43,1402,0.962,"norepinephrine, isoetharine",0.366531544420413,0.0168249279621871,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",0.29737,0.766,0.724,135,0.903,"practolol, propranolol, idazoxan",0.140261433802853,0.0443122496864942,FALSE
+"HCC95","Pearson.est","AKT inhibitor",0.35332,0.916,0.509,366,0.866,"MK.2206, palomid.529, AT7867, ONC201, triciribine",0.293282217663241,0.0624821079826534,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.36842,-0.993,0.44,1218,0.973,"alectinib, CEP.37440, DMH1",0.356547323513813,0.0118871597316481,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",-0.71887,-1.86,0.00641,1160,0.155,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.19314197048118,0.809668301829709,TRUE
+"HCC95","Pearson.est","antioxidant",-0.64067,-1.65,0.0379,1100,0.354,"benfotiamine, trolox",1.42136079003193,0.450996737974212,FALSE
+"HCC95","Pearson.est","AP inhibitor",0.59967,1.54,0.0766,49,0.889,"birinapant, GDC.0152",1.1157712303674,0.0510982390297863,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",0.43523,1.11,0.35,281,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin....",0.455931955649724,0,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",0.25077,0.632,0.901,291,0.941,"MK.5108, barasertib.HQPA, MK.8745, barasertib, ENMD.2076, alisertib",0.045275209020937,0.0264103765727431,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40285,-1.06,0.377,1328,0.951,"azalomycin.b, dirithromycin",0.423658649794207,0.0218194830625861,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.40919,1.05,0.397,375,1,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.401209493236885,0,FALSE
+"HCC95","Pearson.est","BCL inhibitor",-0.41438,-1.1,0.319,1416,1,"gossypol, ABT.737",0.496209316942819,0,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",0.2699,0.688,0.812,256,0.932,"dasatinib, metatinib, bafetinib",0.0904439707588247,0.0305840876460186,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",0.46636,1.22,0.245,92,0.978,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.610833915635468,0.00966114521239857,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",-0.38818,-1.01,0.422,1165,0.975,"I.BET151, PFI.1",0.374687549038326,0.0109953843014632,FALSE
+"HCC95","Pearson.est","calcium channel blocker",-0.26303,-0.693,0.823,1123,0.946,"efonidipine.monoethanolate, SR.33805, mibefradil",0.0846001647877302,0.0241088635982073,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.24636,-0.652,0.87,355,0.951,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, PF.04136309, navarixin",0.0604807473813815,0.0218194830625861,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.27016,-0.714,0.821,942,0.991,"AZD5438, PHA.848125, arcyriaflavin.a, R547, palbociclib, indirubin, abemaciclib, JNJ.7706621, BMS.265246, ribociclib, TG.02",0.0856568428805592,0.00392634551472468,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.50632,-1.31,0.177,1202,0.814,"SCH.900776, AZD7762, SB.218078",0.752026733638193,0.0893755951107988,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.42313,-1.12,0.314,1260,1,"AM.404, tryptanthrin, acetylsalicylsalicylic.acid, piroxicam, FR.122047, naproxen",0.503070351926785,0,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.57473,1.46,0.0951,262,0.953,"PF.4981517, morin, eplerenone",1.02181948306259,0.0209070993616736,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.43799,-1.16,0.253,1117,1,"melphalan, carmustine, mitomycin.c, streptozotocin, satraplatin, temozolomide, cyclophosphamide",0.596879478824182,0,FALSE
+"HCC95","Pearson.est","DNA inhibitor",-0.24957,-0.663,0.852,1117,0.962,"melphalan, carmustine, busulfan, nithiamide, pibenzimol",0.0695604052332999,0.0168249279621871,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",0.46339,1.2,0.278,551,0.936,"SGI.1027, fdcyd, azacitidine, decitabine",0.555955204081924,0.0287241512618947,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",0.4034,1.02,0.408,300,0.908,"foscarnet, cephalomannine, cidofovir, idoxuridine",0.38933983691012,0.0419141514789149,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.24103,-0.625,0.9,1437,0.958,"enocitabine",0.0457574905606751,0.0186344909214556,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",-0.34135,-0.908,0.533,1150,0.93,"mesoridazine, remoxipride, ziprasidone, paliperidone, lurasidone, amisulpride",0.273272790973428,0.0315170514460649,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.28523,-0.745,0.77,1404,0.969,"erteberel",0.113509274827518,0.0136762229492347,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",-0.83815,-2.15,0,1333,0.0504,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.29756946355447,TRUE
+"HCC95","Pearson.est","FGFR inhibitor",-0.30717,-0.815,0.632,1074,0.928,"MK.2461, nintedanib, lenvatinib, lucitanib",0.199282921717615,0.0324520237811379,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",-0.39654,-1.03,0.411,1174,0.974,"ponatinib, KW.2449, pacritinib, quizartinib, TG.02, sunitinib, lestaurtinib",0.386158178123931,0.0114410431213845,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.36764,-0.966,0.473,980,0.909,"triamcinolone.acetonide, rimexolone, halcinonide, fludroxycortide, prednisolone, flumethasone, triamcinolone, prednisolone.acetate, piretanide, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, hydrocortisone, flumethasone.pivalate, dexamethasone.acetate",0.325138859262188,0.0414361167780325,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",0.33886,0.842,0.637,349,0.974,"ACDPP, tiletamine, kynurenic.acid, CGP.37849",0.19586056766465,0.0114410431213845,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.40081,1.05,0.367,36,1,"CHIR.99021",0.435333935747911,0,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.64846,-1.68,0.0477,1254,0.367,"GSK1838705A, GW.441756, lestaurtinib",1.32148162095989,0.435333935747911,FALSE
+"HCC95","Pearson.est","HCV inhibitor",0.55748,1.45,0.0975,44,0.794,"daclatasvir",1.01099538430146,0.100179497572904,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",0.4075,1.05,0.393,378,1,"nexturastat.a, panobinostat, chidamide, belinostat, NSC.3852, scriptaid, SB.939, ACY.1215, entinostat, M.344, resminostat",0.405607449624573,0,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",-0.23231,-0.608,0.895,1242,0.953,"tiotidine, ebastine, epinastine, BF2.649",0.048176964684088,0.0209070993616736,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.5215,1.35,0.152,310,0.826,"atorvastatin, simvastatin, pitavastatin",0.818156412055227,0.0830199526796178,FALSE
+"HCC95","Pearson.est","HSP inhibitor",0.48376,1.26,0.202,326,0.972,"BIIB021, NMS.E973, PU.H71, SNX.5422, SNX.2112, NVP.AUY922, ganetespib, KW.2478",0.694648630553376,0.0123337350737254,FALSE
+"HCC95","Pearson.est","JAK inhibitor",-0.34799,-0.933,0.505,998,0.91,"AT.9283, PRT062070, TG.101348, CEP.33779, AZD1480, filgotinib, pacritinib, TG.02, lestaurtinib",0.296708621881339,0.0409586076789064,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.37258,-0.962,0.498,1175,0.881,"lenvatinib, KI.8751, imatinib, telatinib, vatalanib, sunitinib, masitinib",0.302770657240282,0.0550240915879521,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.21012,0.54,0.965,1145,0.96,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.0154726866562074,0.0177287669604316,FALSE
+"HCC95","Pearson.est","MEK inhibitor",-0.30583,-0.818,0.678,1284,0.951,"nobiletin, MEK162, BIX.02188, arctigenin",0.168770306132937,0.0218194830625861,FALSE
+"HCC95","Pearson.est","MET inhibitor",-0.71135,-1.87,0.0128,1233,0.188,"INC.280, PHA.665752, AMG458, NVP.BVU972",1.89279003035213,0.72584215073632,TRUE
+"HCC95","Pearson.est","microtubule inhibitor",0.37755,0.98,0.467,182,0.898,"estramustine.phosphate, triclabendazole",0.330683119433888,0.0467236633326956,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",0.68759,1.73,0.00916,332,0.937,"deforolimus, PI.103, AZD8055, PKI.179, torin.1, everolimus, LY3023414, NVP.BEZ235, temsirolimus, MLN0128, PP242, AZD2014, GDC.0980, WYE.125132, torin.2, sirolimus, SB.2343, voxtalisib, palomid.529, PF.04691502",2.03810452633215,0.0282604091122217,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",-0.42576,-1.09,0.349,1079,0.981,"IKK.2.inhibitor.V, curcumin, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.45717457304082,0.0083309926200515,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",-0.41695,-1.1,0.345,1262,1,"ADL5859, salvinorin.a",0.462180904926726,0,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",-0.22533,-0.584,0.94,896,0.951,"talmapimod, CMPD.1, TAK.715, skepinone.l",0.0268721464003014,0.0218194830625861,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.54924,-1.47,0.0954,972,0.511,"niraparib, olaparib, AZD2461, AG.14361, talazoparib",1.0204516252959,0.291579099865287,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45414,-1.19,0.235,1130,1,"nintedanib, ponatinib, lenvatinib, KI.8751, axitinib, imatinib, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.628932137728264,0,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",-0.29123,-0.786,0.676,1177,0.927,"menadione, CID.5458317, alexidine",0.170053304058364,0.0329202658555029,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.27143,0.714,0.781,275,0.924,"papaverine, enoximone, EMD.53998",0.1073489661227,0.0343280287798933,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",0.3149,0.796,0.694,90,0.915,"PI.103, PKI.179, BGT226, LY3023414, NVP.BEZ235",0.158640529545145,0.0385789059335517,FALSE
+"HCC95","Pearson.est","PLK inhibitor",0.31437,0.808,0.694,995,0.928,"HMN.214, BI.2536, NMS.1286937, volasertib, rigosertib, GSK461364, GW.843682X",0.158640529545145,0.0324520237811379,FALSE
+"HCC95","Pearson.est","potassium channel blocker",0.63103,1.63,0.0472,422,0.856,"ML133, ibutilide, oleoylethanolamide, dofetilide, mepivacaine",1.32605800136591,0.0675262353228468,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",-0.26982,-0.71,0.814,979,0.971,"GW.501516, S26948, clofibrate, fenofibrate",0.0893755951107988,0.0127807700919951,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",-0.61232,-1.62,0.0552,1148,0.347,"dienogest, norgestrel, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.2580609222708,0.459670525209126,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",0.39475,1.02,0.418,183,0.908,"ONX.0914, MG.132",0.378823718224965,0.0419141514789149,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",0.29296,0.761,0.732,421,0.882,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, azomycin..2.nitroimidazole., chloramphenicol.palmitate",0.135488918941608,0.0545314148681803,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.32526,-0.86,0.587,1331,0.966,"CP.724714, rheochrysidin",0.231361898752386,0.0150228735845067,FALSE
+"HCC95","Pearson.est","RAF inhibitor",0.38643,0.99,0.446,368,0.925,"SB.590885, vemurafenib, dabrafenib, sorafenib, LGX818",0.350665141287858,0.0338582672609674,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.40723,-1.08,0.38,1410,0.949,"sunitinib",0.42021640338319,0.0227337875727074,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.30082,-0.806,0.696,1056,0.918,"CD.437, adarotene, AM.580",0.157390760389438,0.0371573187987575,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.36759,-0.976,0.455,1439,0.926,"pentostatin",0.341988603342888,0.0333890133180656,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.32309,-0.832,0.658,1142,0.987,"NAN.190, ipsapirone, zolmitriptan",0.181774106386044,0.00568284733036327,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",0.32578,0.84,0.652,342,0.939,"SB.200646, sertindole, aripiprazole, lerisetron, SB.228357, pirenperone",0.18575240426808,0.0273344077338891,FALSE
+"HCC95","Pearson.est","sodium channel blocker",0.36806,0.937,0.519,426,0.904,"brivaracetam, ajmaline, cibenzoline, butamben, mepivacaine, mexiletine",0.284832642151542,0.0438315695246367,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.34274,-0.9,0.559,1278,0.914,"PP.2, masitinib",0.252588192113577,0.0390538042661686,FALSE
+"HCC95","Pearson.est","sterol demethylase inhibitor",0.36519,0.944,0.493,13,0.934,"chlormidazole",0.30715308072277,0.0296531237699066,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.57606,-1.49,0.107,1020,0.532,"SB.431542, adaprev, repsox, D.4476, SB.525334",0.97061622231479,0.274088367704952,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.31623,-0.82,0.649,456,0.978,"ftorafur, raltitrexed, carmofur, doxifluridine, capecitabine, trifluridine",0.187755303199631,0.00966114521239857,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",0.25312,0.653,0.877,174,0.946,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate",0.0570004066339595,0.0241088635982073,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",0.36216,0.925,0.532,544,0.888,"mebendazole, epothilone.b, BNC105, oxibendazole, vinorelbine, CYT.997, indibulin, taltobulin, fenbendazole, verubulin, KX2.391, dolastatin.10, plinabulin, parbendazole, podophyllotoxin",0.274088367704952,0.051587034221399,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",0.23237,0.593,0.912,470,0.949,"dasatinib, AV.412, mubritinib, NVP.TAE226, bafetinib, GTP.14564, sorafenib, vandetanib, tyrphostin.A9, tivantinib, apatinib",0.0400051616715838,0.0227337875727074,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.20758,-0.562,0.947,1049,0.947,"AEE788, MK.2461, tivozanib, nintedanib, lenvatinib, KI.8751, axitinib, lucitanib, foretinib, telatinib, vatalanib, sunitinib",0.0236500209967266,0.0236500209967266,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",0.54269,1.4,0.134,465,0.805,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol",0.872895201635192,0.0942041196321315,FALSE
+"H3255","Pearson.est","EGFR inhibitor",0.47647,1.22,0.232,368,1,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, canertinib, WZ.3146, gefitinib, brigatinib, AST.1306, BIBU.1361, PD.168393, icotinib, BIBX.1382, AZD8931, lapatinib, afatinib, rociletinib, pelitinib, osimertinib",0.6345120151091,0,FALSE
+"H3255","Pearson.est","Abl kinase inhibitor",0.33791,0.856,0.631,232,0.881,"dasatinib, metatinib, bafetinib",0.199970640755866,0.0550240915879521,FALSE
+"H3255","Pearson.est","acetylcholine receptor agonist",0.29605,0.757,0.74,306,0.853,"xanomeline, oxiracetam",0.130768280269024,0.069050968832477,FALSE
+"H3255","Pearson.est","acetylcholine receptor antagonist",-0.76141,-2.01,0,1309,0.0687,"dicycloverine, methscopolamine, iododexetimide",Inf,1.16304326294045,TRUE
+"H3255","Pearson.est","adenosine receptor antagonist",0.3399,0.884,0.582,173,0.861,"theophylline, PSB.1115",0.235077015350112,0.0649968485463452,FALSE
+"H3255","Pearson.est","adrenergic receptor agonist",-0.39644,-1.06,0.345,1247,0.986,"methyldopa, ritodrine, norepinephrine, isoetharine",0.462180904926726,0.0061230850587888,FALSE
+"H3255","Pearson.est","adrenergic receptor antagonist",0.37475,0.961,0.471,167,0.886,"practolol, idazoxan, propranolol, vincamine",0.326979092871104,0.0525662781129492,FALSE
+"H3255","Pearson.est","AKT inhibitor",0.44547,1.12,0.327,341,0.987,"triciribine, MK.2206, AT7867, ONC201, palomid.529",0.485452247339714,0.00568284733036327,FALSE
+"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27517,-0.73,0.791,1187,0.883,"alectinib, CEP.37440, DMH1",0.101823516502323,0.0540392964224314,FALSE
+"H3255","Pearson.est","androgen receptor antagonist",-0.74927,-2.01,0.00642,1212,0.0687,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.19246497193115,1.16304326294045,TRUE
+"H3255","Pearson.est","antioxidant",-0.57031,-1.5,0.0708,1114,0.485,"benfotiamine, trolox",1.14996674231023,0.314258261397736,FALSE
+"H3255","Pearson.est","AP inhibitor",0.60776,1.57,0.0627,81,0.807,"birinapant, GDC.0152",1.20273245916928,0.0931264652779296,FALSE
+"H3255","Pearson.est","ATPase inhibitor",0.3926,1.01,0.431,498,0.907,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873, thonzonium, digoxin",0.365522729839268,0.0423927129399047,FALSE
+"H3255","Pearson.est","Aurora kinase inhibitor",0.38544,0.988,0.447,464,0.866,"barasertib, barasertib.HQPA, MK.8745, alisertib, MK.5108, ENMD.2076, ZM.447439, PF.03814735, CCT137690, danusertib, SNS.314",0.349692476868064,0.0624821079826534,FALSE
+"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.27758,-0.733,0.774,1244,0.902,"azalomycin.b, dirithromycin",0.111259039317107,0.0447934624580583,FALSE
+"H3255","Pearson.est","bacterial DNA gyrase inhibitor",0.35823,0.935,0.507,393,0.863,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.294992040666664,0.0639892042847904,FALSE
+"H3255","Pearson.est","BCL inhibitor",-0.37109,-0.959,0.464,1398,1,"gossypol, ABT.737",0.333482019445119,0,FALSE
+"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.39713,1.02,0.386,232,0.99,"dasatinib, metatinib, bafetinib",0.413412695328245,0.00436480540245009,FALSE
+"H3255","Pearson.est","benzodiazepine receptor agonist",0.41276,1.06,0.378,129,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.422508200162775,0,FALSE
+"H3255","Pearson.est","bromodomain inhibitor",-0.42149,-1.08,0.348,1180,1,"I.BET151, PFI.1",0.458420756053419,0,FALSE
+"H3255","Pearson.est","calcium channel blocker",-0.34179,-0.891,0.556,1111,1,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.254925208417942,0,FALSE
+"H3255","Pearson.est","CC chemokine receptor antagonist",-0.28938,-0.75,0.755,417,0.901,"ZK811752, MK.0812, UNBS.5162, RS.504393, SB.225002, navarixin, PF.04136309",0.122053048370812,0.045275209020937,FALSE
+"H3255","Pearson.est","CDK inhibitor",-0.15919,-0.415,0.998,227,0.996,"alvocidib, NU6027, CR8..R., kenpaullone, AT.7519, dinaciclib, P276.00, aminopurvalanol.a, indisulam, PHA.793887, BMS.387032, palbociclib, arcyriaflavin.a, PHA.848125, R547, AZD5438, abemaciclib, indirubin, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.000869458712628891,0.00174066157630127,FALSE
+"H3255","Pearson.est","CHK inhibitor",-0.49896,-1.31,0.179,1174,0.751,"SCH.900776, AZD7762, SB.218078",0.747146969020107,0.124360062995832,FALSE
+"H3255","Pearson.est","cyclooxygenase inhibitor",-0.40463,-1.08,0.358,1231,1,"acetylsalicylsalicylic.acid, AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.446116973356126,0,FALSE
+"H3255","Pearson.est","cytochrome P450 inhibitor",0.5224,1.32,0.17,295,0.989,"PF.4981517, morin, eplerenone",0.769551078621726,0.0048037084028206,FALSE
+"H3255","Pearson.est","DNA alkylating agent",-0.3224,-0.885,0.586,1045,0.984,"streptozotocin, carmustine, melphalan, satraplatin, cyclophosphamide, temozolomide",0.232102383981909,0.00700490156865849,FALSE
+"H3255","Pearson.est","DNA inhibitor",-0.24169,-0.642,0.868,1358,0.948,"pibenzimol, nithiamide",0.0614802748235081,0.0231916626619338,FALSE
+"H3255","Pearson.est","DNA methyltransferase inhibitor",0.65378,1.69,0.0331,411,0.609,"SGI.1027, azacitidine, decitabine, fdcyd",1.48017200622428,0.215382707367125,FALSE
+"H3255","Pearson.est","DNA polymerase inhibitor",0.46659,1.18,0.266,171,1,"foscarnet, cidofovir, cephalomannine, idoxuridine",0.575118363368933,0,FALSE
+"H3255","Pearson.est","DNA synthesis inhibitor",-0.32865,-0.864,0.607,1388,0.955,"altretamine, enocitabine",0.216811308924742,0.0199966284162537,FALSE
+"H3255","Pearson.est","dopamine receptor antagonist",-0.34498,-0.907,0.54,1188,1,"ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.267606240177031,0,FALSE
+"H3255","Pearson.est","estrogen receptor agonist",-0.33647,-0.864,0.616,1126,0.955,"ethinyl.estradiol, estrone, erteberel",0.210419287835575,0.0199966284162537,FALSE
+"H3255","Pearson.est","estrogen receptor antagonist",-0.78386,-2.1,0.00233,1287,0.0939,"danazol, raloxifene, fulvestrant, tamoxifen",2.63264407897398,1.02733440773389,TRUE
+"H3255","Pearson.est","FGFR inhibitor",-0.22949,-0.607,0.923,330,0.959,"orantinib, AZD4547, regorafenib, erdafitinib, PD.173074, dovitinib, nintedanib, MK.2461, lenvatinib, lucitanib",0.0347982989740879,0.0181813928293364,FALSE
+"H3255","Pearson.est","FLT3 inhibitor",-0.3107,-0.826,0.668,1171,0.935,"TG.101348, KW.2449, quizartinib, TG.02, sunitinib, lestaurtinib",0.175223537524454,0.0291883891274822,FALSE
+"H3255","Pearson.est","glucocorticoid receptor agonist",-0.35685,-0.948,0.502,956,1,"flumethasone, desonide, halcinonide, triamcinolone.acetonide, rimexolone, fludroxycortide, prednisolone, triamcinolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.299296282854981,0,FALSE
+"H3255","Pearson.est","glutamate receptor antagonist",0.30336,0.758,0.77,258,0.877,"ACDPP, tiletamine, kynurenic.acid",0.113509274827518,0.0570004066339595,FALSE
+"H3255","Pearson.est","glycogen synthase kinase inhibitor",0.37363,0.96,0.456,31,0.85,"CHIR.99021",0.341035157335565,0.0705810742857073,FALSE
+"H3255","Pearson.est","growth factor receptor inhibitor",-0.51585,-1.36,0.148,1176,0.709,"GSK1838705A, GW.441756, lestaurtinib",0.829738284605043,0.149353764816933,FALSE
+"H3255","Pearson.est","HCV inhibitor",0.40114,1.02,0.435,63,0.99,"daclatasvir",0.361510743045363,0.00436480540245009,FALSE
+"H3255","Pearson.est","HDAC inhibitor",0.46123,1.16,0.263,407,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, M.344, ACY.1215, entinostat, resminostat, mocetinostat, romidepsin, givinostat",0.580044251510242,0,FALSE
+"H3255","Pearson.est","histamine receptor antagonist",-0.25592,-0.671,0.829,1103,0.938,"cyproheptadine, terfenadine, tiotidine, ranitidine, ebastine, BF2.649, epinastine",0.0814454694497265,0.0277971616209356,FALSE
+"H3255","Pearson.est","HMGCR inhibitor",0.31895,0.808,0.686,257,0.875,"atorvastatin, simvastatin",0.163675884293248,0.0579919469776868,FALSE
+"H3255","Pearson.est","HSP inhibitor",0.56564,1.45,0.0994,216,0.709,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, SNX.2112, ganetespib, SNX.5422",1.00261361560269,0.149353764816933,FALSE
+"H3255","Pearson.est","JAK inhibitor",-0.31267,-0.84,0.609,1171,0.971,"TG.101348, filgotinib, AZD1480, CEP.33779, TG.02, lestaurtinib",0.215382707367125,0.0127807700919951,FALSE
+"H3255","Pearson.est","KIT inhibitor",0.29528,0.765,0.75,80,0.892,"midostaurin, OSI.930, dasatinib",0.1249387366083,0.0496351456238769,FALSE
+"H3255","Pearson.est","MDM inhibitor",-0.29196,-0.768,0.744,421,0.898,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.128427064454121,0.0467236633326956,FALSE
+"H3255","Pearson.est","MEK inhibitor",-0.30982,-0.831,0.641,1197,0.957,"refametinib, nobiletin, MEK162, arctigenin, BIX.02188",0.193141970481183,0.0190880622231565,FALSE
+"H3255","Pearson.est","MET inhibitor",-0.61545,-1.6,0.0516,1144,0.422,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.28735029837279,0.374687549038326,FALSE
+"H3255","Pearson.est","microtubule inhibitor",0.42306,1.11,0.312,151,0.942,"estramustine.phosphate, triclabendazole",0.505845405981557,0.0259490972071227,FALSE
+"H3255","Pearson.est","mTOR inhibitor",0.69455,1.78,0.0156,190,0.677,"deforolimus, PI.103, AZD8055, PKI.179, everolimus, torin.1, NVP.BEZ235, temsirolimus, MLN0128, LY3023414, AZD2014, PP242, GDC.0980, WYE.125132, sirolimus, torin.2",1.80687540164554,0.169411331314856,FALSE
+"H3255","Pearson.est","NFkB pathway inhibitor",-0.40553,-1.08,0.332,1039,1,"curcumin, tyloxapol, IKK.2.inhibitor.V, Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.478861916295964,0,FALSE
+"H3255","Pearson.est","opioid receptor agonist",-0.41123,-1.07,0.357,1268,1,"ADL5859, salvinorin.a",0.447331783887807,0,FALSE
+"H3255","Pearson.est","p38 MAPK inhibitor",-0.21056,-0.556,0.945,1150,0.974,"TAK.715, skepinone.l",0.0245681914907371,0.0114410431213845,FALSE
+"H3255","Pearson.est","PARP inhibitor",-0.59429,-1.56,0.0751,1033,0.432,"niraparib, AZD2461, olaparib, AG.14361, talazoparib",1.12436006299583,0.364516253185088,FALSE
+"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.29832,-0.813,0.649,1116,0.872,"lenvatinib, KI.8751, axitinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.187755303199631,0.0594835150674328,FALSE
+"H3255","Pearson.est","phosphatase inhibitor",-0.30875,-0.796,0.688,1159,0.876,"CID.5458317, menadione, alexidine",0.162411561764489,0.0574958938319193,FALSE
+"H3255","Pearson.est","phosphodiesterase inhibitor",0.27198,0.689,0.825,259,0.873,"papaverine, enoximone, EMD.53998",0.0835460514500749,0.0589857562944303,FALSE
+"H3255","Pearson.est","PI3K inhibitor",0.38613,1,0.451,493,0.884,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, GDC.0980, voxtalisib, SB.2343, PF.04691502, ZSTK.474, buparlisib, PF.05212384, PI3K.IN.2, CUDC.907, PI.828",0.345823458122039,0.0535477349869269,FALSE
+"H3255","Pearson.est","PLK inhibitor",0.36849,0.922,0.532,917,0.82,"HMN.214, BI.2536, volasertib, NMS.1286937, rigosertib, GSK461364, GW.843682X",0.274088367704952,0.0861861476162833,FALSE
+"H3255","Pearson.est","potassium channel blocker",0.5926,1.51,0.0622,423,0.813,"ML133, ibutilide, oleoylethanolamide, mepivacaine, dofetilide",1.20620961530918,0.0899094544059319,FALSE
+"H3255","Pearson.est","PPAR receptor agonist",-0.31467,-0.823,0.681,968,0.911,"GW.501516, S26948, clofibrate, fenofibrate",0.166852888087215,0.0404816230270017,FALSE
+"H3255","Pearson.est","progesterone receptor agonist",-0.71483,-1.88,0.0129,1208,0.139,"norgestrel, melengestrol.acetate, dienogest, nomegestrol.acetate, danazol, norethindrone.acetate",1.88941028970075,0.856985199745905,TRUE
+"H3255","Pearson.est","proteasome inhibitor",0.43907,1.14,0.3,146,1,"ONX.0914, MG.132",0.522878745280338,0,FALSE
+"H3255","Pearson.est","protein synthesis inhibitor",0.26051,0.675,0.83,297,0.866,"clofoctol, cycloheximide, thiostrepton, puromycin, brefeldin.a",0.0809219076239261,0.0624821079826534,FALSE
+"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.33138,0.846,0.642,198,0.868,"AV.412, NVP.TAE226, mubritinib",0.192464971931147,0.0614802748235081,FALSE
+"H3255","Pearson.est","RAF inhibitor",0.49427,1.24,0.246,338,1,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.609064892896621,0,FALSE
+"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.30972,-0.821,0.661,1375,0.885,"sunitinib",0.17979854051436,0.0530567293021746,FALSE
+"H3255","Pearson.est","retinoid receptor agonist",0.27529,0.703,0.815,102,0.878,"LE.135",0.0888423912600234,0.0565054840938974,FALSE
+"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.36591,-0.978,0.462,1438,1,"pentostatin",0.335358024443874,0,FALSE
+"H3255","Pearson.est","serotonin receptor agonist",-0.64949,-1.69,0.0566,1179,0.337,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",1.24718356881173,0.472370099128661,FALSE
+"H3255","Pearson.est","serotonin receptor antagonist",-0.3813,-1,0.422,1088,1,"RS.16566, tropisetron, ziprasidone, paliperidone, lurasidone, aripiprazole",0.374687549038326,0,FALSE
+"H3255","Pearson.est","sodium channel blocker",0.31361,0.802,0.669,486,0.858,"brivaracetam, ajmaline, butamben, mepivacaine, cibenzoline, mexiletine",0.174573882232177,0.0665127121512946,FALSE
+"H3255","Pearson.est","src inhibitor",-0.34036,-0.906,0.559,1294,1,"PP.2, masitinib",0.252588192113577,0,FALSE
+"H3255","Pearson.est","sterol demethylase inhibitor",0.36053,0.925,0.527,10,0.847,"chlormidazole",0.278189384787453,0.0721165896692931,FALSE
+"H3255","Pearson.est","TGF beta receptor inhibitor",-0.45113,-1.22,0.234,941,0.906,"repsox, adaprev, SB.431542, D.4476, SB.525334",0.630784142589857,0.0428718023231869,FALSE
+"H3255","Pearson.est","thymidylate synthase inhibitor",-0.34327,-0.908,0.545,495,1,"ftorafur, raltitrexed, carmofur, doxifluridine, capecitabine, trifluridine",0.263603497723358,0,FALSE
+"H3255","Pearson.est","topoisomerase inhibitor",0.27234,0.709,0.824,157,0.895,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin",0.0840727883028842,0.048176964684088,FALSE
+"H3255","Pearson.est","tubulin polymerization inhibitor",0.40052,1.01,0.423,492,0.907,"epothilone.b, mebendazole, oxibendazole, BNC105, vinorelbine, CYT.997, fenbendazole, taltobulin, verubulin, indibulin, plinabulin, parbendazole, KX2.391, dolastatin.10",0.373659632624958,0.0423927129399047,FALSE
+"H3255","Pearson.est","tyrosine kinase inhibitor",0.31492,0.812,0.677,522,0.898,"dasatinib, AV.412, NVP.TAE226, mubritinib, bafetinib, sorafenib, tyrphostin.A9, GTP.14564, tivantinib, vandetanib, apatinib, PP.121, regorafenib, aminopurvalanol.a",0.169411331314856,0.0467236633326956,FALSE
+"H3255","Pearson.est","VEGFR inhibitor",0.22416,0.59,0.947,118,0.927,"BMS.690514, OSI.930, XL.647, SAR131675",0.0236500209967266,0.0329202658555029,FALSE
+"H3255","Pearson.est","vitamin D receptor agonist",0.57496,1.46,0.105,524,0.815,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol, doxercalciferol",0.978810700930062,0.0888423912600234,FALSE
+"H1648","Pearson.est","EGFR inhibitor",0.43902,1.14,0.287,414,1,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, canertinib, WZ.3146, brigatinib, gefitinib, AST.1306, PD.168393, BIBU.1361, icotinib, AZD8931, lapatinib, pelitinib, BIBX.1382, osimertinib, afatinib, rociletinib, GW.583340, vandetanib",0.542118103266008,0,FALSE
+"H1648","Pearson.est","Abl kinase inhibitor",0.33285,0.842,0.611,186,0.861,"dasatinib, metatinib, bafetinib",0.213958789757446,0.0649968485463452,FALSE
+"H1648","Pearson.est","acetylcholine receptor agonist",0.2306,0.581,0.946,127,0.962,"xanomeline",0.0241088635982073,0.0168249279621871,FALSE
+"H1648","Pearson.est","acetylcholine receptor antagonist",-0.7901,-2.09,0.00421,1327,0.0437,"dicycloverine, methscopolamine, iododexetimide",2.37571790416433,1.35951856302958,TRUE
+"H1648","Pearson.est","adenosine receptor antagonist",0.37232,0.955,0.48,137,0.884,"theophylline, PSB.1115",0.318758762624413,0.0535477349869269,FALSE
+"H1648","Pearson.est","adrenergic receptor agonist",-0.37097,-0.983,0.474,1413,0.926,"norepinephrine, isoetharine",0.324221658325915,0.0333890133180656,FALSE
+"H1648","Pearson.est","adrenergic receptor antagonist",0.3527,0.908,0.562,178,0.868,"practolol, idazoxan, propranolol, vincamine",0.250263684430939,0.0614802748235081,FALSE
+"H1648","Pearson.est","AKT inhibitor",0.45328,1.16,0.279,345,1,"MK.2206, triciribine, AT7867, palomid.529, ONC201",0.554395796726402,0,FALSE
+"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.29754,-0.769,0.724,1169,0.91,"alectinib, CEP.37440, DMH1",0.140261433802853,0.0409586076789064,FALSE
+"H1648","Pearson.est","androgen receptor antagonist",-0.74899,-1.99,0.00638,1172,0.0688,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.19517932127884,1.16241156176449,TRUE
+"H1648","Pearson.est","antioxidant",-0.62411,-1.61,0.0678,1124,0.358,"benfotiamine, trolox",1.16877030613294,0.446116973356126,FALSE
+"H1648","Pearson.est","AP inhibitor",0.64659,1.65,0.045,68,0.794,"birinapant, GDC.0152",1.34678748622466,0.100179497572904,FALSE
+"H1648","Pearson.est","ATPase inhibitor",0.38965,1.03,0.381,373,0.852,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.419075024324381,0.0695604052332999,FALSE
+"H1648","Pearson.est","Aurora kinase inhibitor",0.26311,0.689,0.817,510,0.928,"MK.5108, barasertib.HQPA, barasertib, ENMD.2076, alisertib, MK.8745, ZM.447439, PF.03814735, CCT137690, danusertib",0.0877779434675845,0.0324520237811379,FALSE
+"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.3809,-1.03,0.395,1314,1,"azalomycin.b, dirithromycin",0.40340290437354,0,FALSE
+"H1648","Pearson.est","bacterial DNA gyrase inhibitor",0.34199,0.886,0.582,269,0.81,"lomefloxacin, novobiocin, finafloxacin",0.235077015350112,0.0915149811213502,FALSE
+"H1648","Pearson.est","BCL inhibitor",-0.39017,-1.02,0.389,1401,1,"gossypol, ABT.737",0.410050398674292,0,FALSE
+"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.40257,1.04,0.398,186,0.88,"dasatinib, metatinib, bafetinib",0.400116927926312,0.0555173278498314,FALSE
+"H1648","Pearson.est","benzodiazepine receptor agonist",0.42871,1.1,0.322,108,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.492144128304169,0,FALSE
+"H1648","Pearson.est","bromodomain inhibitor",-0.45891,-1.21,0.248,1220,0.908,"I.BET151, PFI.1",0.605548319173784,0.0419141514789149,FALSE
+"H1648","Pearson.est","calcium channel blocker",-0.31662,-0.829,0.636,1080,0.941,"pranidipine, SR.33805, efonidipine.monoethanolate, mibefradil",0.196542884351586,0.0264103765727431,FALSE
+"H1648","Pearson.est","CC chemokine receptor antagonist",-0.26579,-0.693,0.837,383,0.904,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.07727454200674,0.0438315695246367,FALSE
+"H1648","Pearson.est","CDK inhibitor",-0.2905,-0.762,0.719,1036,0.851,"R547, PHA.848125, AZD5438, indirubin, abemaciclib, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.143271109617117,0.0700704399154121,FALSE
+"H1648","Pearson.est","CHK inhibitor",-0.53591,-1.39,0.139,1193,0.605,"SCH.900776, AZD7762, SB.218078",0.856985199745905,0.218244625347531,FALSE
+"H1648","Pearson.est","cyclooxygenase inhibitor",-0.38464,-1,0.414,1225,0.933,"acetylsalicylsalicylic.acid, AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.382999658879101,0.0301183562535,FALSE
+"H1648","Pearson.est","cytochrome P450 inhibitor",0.50524,1.33,0.155,318,0.904,"PF.4981517, morin, eplerenone",0.809668301829709,0.0438315695246367,FALSE
+"H1648","Pearson.est","DNA alkylating agent",-0.31305,-0.814,0.664,942,0.94,"TH.302, mitomycin.c, carmustine, streptozotocin, melphalan, satraplatin, cyclophosphamide, temozolomide",0.177831920631982,0.0268721464003014,FALSE
+"H1648","Pearson.est","DNA inhibitor",-0.23659,-0.607,0.905,1363,0.935,"pibenzimol, nithiamide",0.0433514207947967,0.0291883891274822,FALSE
+"H1648","Pearson.est","DNA methyltransferase inhibitor",0.60751,1.59,0.0615,564,0.536,"decitabine, SGI.1027, azacitidine, fdcyd, RG108",1.21112488422458,0.27083521030723,FALSE
+"H1648","Pearson.est","DNA polymerase inhibitor",0.41069,1.07,0.386,238,0.919,"foscarnet, cephalomannine, cidofovir, idoxuridine",0.413412695328245,0.0366844886138887,FALSE
+"H1648","Pearson.est","DNA synthesis inhibitor",-0.33966,-0.886,0.564,1388,0.957,"altretamine, enocitabine",0.248720896016658,0.0190880622231565,FALSE
+"H1648","Pearson.est","dopamine receptor antagonist",-0.3466,-0.903,0.545,1190,0.956,"ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.263603497723358,0.0195421077238999,FALSE
+"H1648","Pearson.est","estrogen receptor agonist",-0.2993,-0.779,0.708,1101,0.974,"ethinyl.estradiol, estrone, erteberel",0.149966742310231,0.0114410431213845,FALSE
+"H1648","Pearson.est","estrogen receptor antagonist",-0.80953,-2.18,0,1265,0.0261,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.58335949266172,TRUE
+"H1648","Pearson.est","FGFR inhibitor",-0.2427,-0.633,0.878,349,0.953,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, nintedanib, MK.2461, lenvatinib, lucitanib",0.0565054840938974,0.0209070993616736,FALSE
+"H1648","Pearson.est","FLT3 inhibitor",-0.3725,-1,0.433,1155,0.933,"pacritinib, TG.101348, quizartinib, KW.2449, TG.02, sunitinib, lestaurtinib",0.363512103646635,0.0301183562535,FALSE
+"H1648","Pearson.est","glucocorticoid receptor agonist",-0.39656,-1.05,0.377,999,1,"halcinonide, desonide, triamcinolone.acetonide, flumethasone, rimexolone, triamcinolone, prednisolone, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, piretanide, fluocinolone.acetonide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.423658649794207,0,FALSE
+"H1648","Pearson.est","glutamate receptor antagonist",0.28994,0.746,0.758,351,0.932,"ACDPP, tiletamine, kynurenic.acid, CGP.37849",0.120330794367946,0.0305840876460186,FALSE
+"H1648","Pearson.est","glycogen synthase kinase inhibitor",0.36302,0.928,0.53,33,0.862,"CHIR.99021",0.275724130399211,0.0644927341752872,FALSE
+"H1648","Pearson.est","growth factor receptor inhibitor",-0.56773,-1.48,0.0875,1012,0.484,"GSK1904529A, PHA.848125, GSK1838705A, GW.441756, lestaurtinib",1.05799194697769,0.315154638355588,FALSE
+"H1648","Pearson.est","HCV inhibitor",0.41064,1.08,0.365,71,0.957,"daclatasvir",0.437707135543525,0.0190880622231565,FALSE
+"H1648","Pearson.est","HDAC inhibitor",0.46699,1.2,0.266,341,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, entinostat, M.344, resminostat, mocetinostat",0.575118363368933,0,FALSE
+"H1648","Pearson.est","histamine receptor antagonist",-0.2381,-0.616,0.927,1003,0.948,"ICI.162846, cyproheptadine, ranitidine, tiotidine, terfenadine, ebastine, epinastine, BF2.649",0.0329202658555029,0.0231916626619338,FALSE
+"H1648","Pearson.est","HMGCR inhibitor",0.40417,1.05,0.381,185,0.91,"atorvastatin, simvastatin",0.419075024324381,0.0409586076789064,FALSE
+"H1648","Pearson.est","HSP inhibitor",0.52317,1.38,0.15,244,0.878,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, SNX.5422, ganetespib",0.823908740944319,0.0565054840938974,FALSE
+"H1648","Pearson.est","JAK inhibitor",-0.377,-1,0.429,1155,0.933,"pacritinib, TG.101348, filgotinib, AZD1480, CEP.33779, TG.02, lestaurtinib",0.367542707815276,0.0301183562535,FALSE
+"H1648","Pearson.est","KIT inhibitor",-0.2915,-0.765,0.746,1294,0.869,"vatalanib, telatinib, sunitinib, masitinib",0.127261172527331,0.0609802235513335,FALSE
+"H1648","Pearson.est","MDM inhibitor",-0.29473,-0.778,0.718,425,0.947,"serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3, RITA",0.1438755557577,0.0236500209967266,FALSE
+"H1648","Pearson.est","MEK inhibitor",-0.32479,-0.858,0.617,1215,0.945,"refametinib, nobiletin, BIX.02188, MEK162, arctigenin",0.209714835966758,0.0245681914907371,FALSE
+"H1648","Pearson.est","MET inhibitor",-0.63363,-1.66,0.0489,1157,0.327,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.31069114087638,0.485452247339714,FALSE
+"H1648","Pearson.est","microtubule inhibitor",0.39871,1.02,0.419,158,0.828,"estramustine.phosphate, triclabendazole",0.377785977033705,0.0819696632151199,FALSE
+"H1648","Pearson.est","mTOR inhibitor",0.68077,1.73,0.0155,311,0.977,"deforolimus, PI.103, AZD8055, PKI.179, everolimus, torin.1, temsirolimus, NVP.BEZ235, LY3023414, MLN0128, AZD2014, PP242, GDC.0980, sirolimus, torin.2, WYE.125132, SB.2343, voxtalisib, palomid.529",1.80966830182971,0.0101054362812269,FALSE
+"H1648","Pearson.est","NFkB pathway inhibitor",-0.42286,-1.09,0.338,1016,1,"tyloxapol, IKK.2.inhibitor.V, curcumin, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.471083299722345,0,FALSE
+"H1648","Pearson.est","opioid receptor agonist",-0.42753,-1.13,0.296,1270,1,"ADL5859, salvinorin.a",0.528708288941061,0,FALSE
+"H1648","Pearson.est","p38 MAPK inhibitor",-0.22903,-0.594,0.92,1089,0.924,"TAK.715, skepinone.l",0.0362121726544447,0.0343280287798933,FALSE
+"H1648","Pearson.est","PARP inhibitor",-0.57872,-1.54,0.0747,1001,0.428,"AZD2461, niraparib, olaparib, AG.14361, talazoparib",1.1266793981846,0.368556230986828,FALSE
+"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30889,-0.83,0.624,1294,0.971,"vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.204815410317576,0.0127807700919951,FALSE
+"H1648","Pearson.est","phosphatase inhibitor",-0.33563,-0.862,0.596,1194,0.971,"menadione, CID.5458317, alexidine",0.224753740259764,0.0127807700919951,FALSE
+"H1648","Pearson.est","phosphodiesterase inhibitor",0.28265,0.734,0.769,278,0.92,"papaverine, enoximone, EMD.53998",0.114073660198569,0.0362121726544447,FALSE
+"H1648","Pearson.est","PI3K inhibitor",0.3714,0.947,0.511,360,0.861,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, SB.2343, voxtalisib, ZSTK.474, PF.04691502, buparlisib",0.291579099865287,0.0649968485463452,FALSE
+"H1648","Pearson.est","PLK inhibitor",0.31783,0.833,0.669,990,0.847,"HMN.214, BI.2536, volasertib, NMS.1286937, GSK461364, rigosertib, GW.843682X",0.174573882232177,0.0721165896692931,FALSE
+"H1648","Pearson.est","potassium channel blocker",0.61961,1.63,0.0454,390,0.588,"ML133, ibutilide, mepivacaine, oleoylethanolamide, dofetilide",1.3429441471429,0.230622673923862,FALSE
+"H1648","Pearson.est","PPAR receptor agonist",-0.28311,-0.748,0.749,1387,0.851,"fenofibrate",0.125518182300534,0.0700704399154121,FALSE
+"H1648","Pearson.est","progesterone receptor agonist",-0.71232,-1.85,0.0172,1214,0.15,"norgestrel, dienogest, danazol, melengestrol.acetate, nomegestrol.acetate, norethindrone.acetate",1.76447155309245,0.823908740944319,TRUE
+"H1648","Pearson.est","proteasome inhibitor",0.34414,0.886,0.567,210,0.81,"ONX.0914, MG.132",0.246416941107093,0.0915149811213502,FALSE
+"H1648","Pearson.est","protein synthesis inhibitor",0.26426,0.682,0.83,304,0.91,"clofoctol, cycloheximide, brefeldin.a, puromycin, thiostrepton",0.0809219076239261,0.0409586076789064,FALSE
+"H1648","Pearson.est","protein tyrosine kinase inhibitor",-0.29945,-0.775,0.711,1338,0.926,"CP.724714, rheochrysidin",0.148130399270234,0.0333890133180656,FALSE
+"H1648","Pearson.est","RAF inhibitor",0.45136,1.17,0.281,371,1,"SB.590885, vemurafenib, LGX818, sorafenib, dabrafenib, AZ.628",0.55129368009492,0,FALSE
+"H1648","Pearson.est","RET tyrosine kinase inhibitor",-0.35813,-0.926,0.54,1397,0.978,"sunitinib",0.267606240177031,0.00966114521239857,FALSE
+"H1648","Pearson.est","retinoid receptor agonist",0.30451,0.789,0.709,280,0.893,"LE.135, adarotene",0.149353764816933,0.0491485411114536,FALSE
+"H1648","Pearson.est","ribonucleotide reductase inhibitor",-0.37293,-0.94,0.505,1441,0.987,"pentostatin",0.296708621881339,0.00568284733036327,FALSE
+"H1648","Pearson.est","serotonin receptor agonist",-0.68253,-1.84,0.0247,1208,0.131,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",1.60730304674033,0.882728704344236,TRUE
+"H1648","Pearson.est","serotonin receptor antagonist",-0.42248,-1.08,0.347,1093,1,"RS.16566, tropisetron, ziprasidone, paliperidone, lurasidone, aripiprazole",0.459670525209126,0,FALSE
+"H1648","Pearson.est","sodium channel blocker",0.37794,0.988,0.473,382,0.853,"brivaracetam, ajmaline, cibenzoline, mepivacaine, butamben, mexiletine",0.325138859262188,0.069050968832477,FALSE
+"H1648","Pearson.est","src inhibitor",-0.35053,-0.909,0.542,1291,0.98,"PP.2, masitinib",0.266000713461613,0.00877392430750515,FALSE
+"H1648","Pearson.est","sterol demethylase inhibitor",0.34072,0.9,0.571,14,0.847,"chlormidazole",0.243363891754152,0.0721165896692931,FALSE
+"H1648","Pearson.est","TGF beta receptor inhibitor",-0.47678,-1.26,0.208,1002,0.846,"SB.431542, adaprev, SB.525334, D.4476",0.681936665037238,0.0726296369609765,FALSE
+"H1648","Pearson.est","thymidylate synthase inhibitor",-0.2982,-0.767,0.736,430,0.889,"ftorafur, doxifluridine, raltitrexed, carmofur, capecitabine, trifluridine",0.133122185662501,0.0510982390297863,FALSE
+"H1648","Pearson.est","topoisomerase inhibitor",0.2791,0.731,0.795,133,0.897,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin",0.0996328713435297,0.0472075569559079,FALSE
+"H1648","Pearson.est","tubulin polymerization inhibitor",0.4118,1.08,0.324,499,0.957,"mebendazole, epothilone.b, oxibendazole, BNC105, CYT.997, vinorelbine, fenbendazole, taltobulin, indibulin, verubulin, dolastatin.10, plinabulin, podophyllotoxin, KX2.391, parbendazole",0.489454989793388,0.0190880622231565,FALSE
+"H1648","Pearson.est","tyrosine kinase inhibitor",0.24889,0.638,0.88,517,0.936,"dasatinib, AV.412, bafetinib, NVP.TAE226, mubritinib, sorafenib, GTP.14564, tyrphostin.A9, vandetanib, tivantinib, apatinib, PP.121, regorafenib",0.0555173278498314,0.0287241512618947,FALSE
+"H1648","Pearson.est","VEGFR inhibitor",0.20014,0.516,0.963,135,0.973,"BMS.690514, XL.647, OSI.930, SAR131675",0.0163737128754655,0.0118871597316481,FALSE
+"H1648","Pearson.est","vitamin D receptor agonist",0.56759,1.43,0.111,515,0.877,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol, doxercalciferol",0.954677021213343,0.0570004066339595,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.40808,1.07,0.356,381,1,"CUDC.101, ARRY.334543, BMS.690514, tyrphostin.AG.1478, erlotinib, WZ.3146, XL.647, canertinib, gefitinib, AST.1306, brigatinib, BIBU.1361, PD.168393, lapatinib, AZD8931, icotinib, BIBX.1382, afatinib, pelitinib, osimertinib",0.448550002027125,0,FALSE
+"H1975","Pearson.est","Abl kinase inhibitor",0.28576,0.734,0.776,226,0.897,"dasatinib, metatinib, bafetinib",0.110138278741812,0.0472075569559079,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",-0.20219,-0.517,0.968,1300,0.972,"nicotine",0.0141246426916063,0.0123337350737254,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",-0.79312,-2.11,0,1299,0.0305,"dicycloverine, methscopolamine, iododexetimide",Inf,1.51570016065321,TRUE
+"H1975","Pearson.est","adenosine receptor antagonist",0.34054,0.88,0.579,153,0.89,"theophylline, PSB.1115",0.237321436272564,0.0506099933550872,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",-0.37351,-0.985,0.454,1416,0.96,"norepinephrine, isoetharine",0.342944147142896,0.0177287669604316,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.32942,0.868,0.609,197,0.879,"practolol, idazoxan, propranolol, vincamine",0.215382707367125,0.0560111249262281,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.39086,1.02,0.401,475,0.996,"MK.2206, triciribine, ONC201, palomid.529, AT7867, GSK2110183",0.396855627379818,0.00174066157630127,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.36373,-0.977,0.464,1214,0.936,"alectinib, CEP.37440, DMH1",0.333482019445119,0.0287241512618947,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",-0.75071,-1.98,0.0102,1223,0.0779,"flutamide, nilutamide, enzalutamide, cyproterone.acetate",1.99139982823808,1.10846254232744,TRUE
+"H1975","Pearson.est","antioxidant",-0.62945,-1.63,0.0487,1141,0.334,"benfotiamine, trolox",1.31247103878537,0.476253533188435,FALSE
+"H1975","Pearson.est","AP inhibitor",0.64682,1.67,0.0383,55,0.677,"birinapant, GDC.0152",1.41680122603138,0.169411331314856,FALSE
+"H1975","Pearson.est","ATPase inhibitor",0.37475,0.975,0.479,215,0.996,"k.strophanthidin, oligomycin.a, ouabain, evodiamine",0.319664486585437,0.00174066157630127,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",0.26124,0.668,0.858,518,0.93,"MK.5108, MK.8745, barasertib.HQPA, barasertib, ENMD.2076, alisertib, ZM.447439, PF.03814735, CCT137690, danusertib, MLN.8054",0.0665127121512946,0.0315170514460649,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36785,-0.964,0.484,1331,0.85,"azalomycin.b, dirithromycin",0.315154638355588,0.0705810742857073,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",0.39227,1.01,0.411,343,0.962,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.386158178123931,0.0168249279621871,FALSE
+"H1975","Pearson.est","BCL inhibitor",-0.39726,-1.04,0.38,1411,1,"gossypol, ABT.737",0.42021640338319,0,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",0.34819,0.903,0.538,226,0.883,"dasatinib, metatinib, bafetinib",0.269217724333611,0.0540392964224314,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.45473,1.18,0.25,98,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.602059991327962,0,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",-0.38166,-1.01,0.433,1163,0.945,"I.BET151, PFI.1",0.363512103646635,0.0245681914907371,FALSE
+"H1975","Pearson.est","calcium channel blocker",-0.34609,-0.899,0.547,1125,0.828,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.262012673666569,0.0819696632151199,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",-0.21374,-0.565,0.949,308,0.989,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.0227337875727074,0.0048037084028206,FALSE
+"H1975","Pearson.est","CDK inhibitor",-0.22725,-0.583,0.932,985,0.998,"PHA.848125, AZD5438, R547, abemaciclib, indirubin, ribociclib, JNJ.7706621, TG.02, BMS.265246",0.0305840876460186,0.000869458712628891,FALSE
+"H1975","Pearson.est","CHK inhibitor",-0.45719,-1.2,0.241,1143,1,"SCH.900776, AZD7762, SB.218078",0.617982957425132,0,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.43817,-1.14,0.283,1256,1,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.54821356447571,0,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",0.50427,1.31,0.176,336,1,"PF.4981517, morin, eplerenone",0.75448733218585,0,FALSE
+"H1975","Pearson.est","DNA alkylating agent",-0.35691,-0.941,0.487,1027,0.833,"TH.302, carmustine, melphalan, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.312471038785366,0.0793549985932124,FALSE
+"H1975","Pearson.est","DNA inhibitor",-0.2777,-0.708,0.788,1379,0.904,"nithiamide, pibenzimol",0.103473782510445,0.0438315695246367,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.62577,1.63,0.0508,457,0.563,"azacitidine, SGI.1027, fdcyd, decitabine",1.29413628771608,0.249491605148654,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",0.3896,1.02,0.449,257,0.996,"foscarnet, cidofovir, cephalomannine, idoxuridine",0.347753658996677,0.00174066157630127,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",-0.28476,-0.736,0.751,1350,0.909,"altretamine, enocitabine",0.124360062995832,0.0414361167780325,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",-0.33187,-0.868,0.588,1034,0.811,"nemonapride, mesoridazine, ziprasidone, remoxipride, paliperidone, lurasidone, amisulpride",0.230622673923862,0.090979145788844,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.37017,-0.97,0.464,1137,0.911,"ethinyl.estradiol, estrone, erteberel",0.333482019445119,0.0404816230270017,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",-0.81816,-2.14,0.00412,1286,0.0474,"danazol, raloxifene, fulvestrant, tamoxifen",2.38510278396687,1.32422165832591,TRUE
+"H1975","Pearson.est","FGFR inhibitor",-0.29302,-0.774,0.731,1005,0.9,"MK.2461, nintedanib, lenvatinib, lucitanib",0.13608262304214,0.0457574905606751,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",-0.39948,-1.02,0.393,1178,0.969,"pacritinib, TG.101348, quizartinib, KW.2449, TG.02, sunitinib, lestaurtinib",0.405607449624573,0.0136762229492347,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",-0.35434,-0.898,0.569,910,0.803,"fludroxycortide, desonide, clobetasol.propionate, triamcinolone.acetonide, halcinonide, flumethasone, triamcinolone, rimexolone, prednisolone, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, piretanide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.244887733604929,0.095284454721319,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",0.3251,0.837,0.657,203,0.871,"ACDPP, tiletamine, kynurenic.acid",0.182434630440219,0.0599818449923368,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",0.3954,1.04,0.421,33,1,"CHIR.99021",0.375717904164332,0,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",-0.58762,-1.55,0.0551,1224,0.417,"GSK1838705A, GW.441756, lestaurtinib",1.25884840114821,0.379863945026242,FALSE
+"H1975","Pearson.est","HCV inhibitor",0.41189,1.06,0.407,54,1,"daclatasvir",0.39040559077478,0,FALSE
+"H1975","Pearson.est","HDAC inhibitor",0.43857,1.15,0.299,445,1,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, scriptaid, SB.939, entinostat, ACY.1215, M.344, resminostat, romidepsin, mocetinostat, givinostat",0.52432881167557,0,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",-0.2434,-0.642,0.878,972,0.963,"lafutidine, ICI.162846, cyproheptadine, ranitidine, terfenadine, tiotidine, ebastine, BF2.649, epinastine",0.0565054840938974,0.0163737128754655,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",0.31035,0.816,0.664,267,0.88,"atorvastatin, simvastatin",0.177831920631982,0.0555173278498314,FALSE
+"H1975","Pearson.est","HSP inhibitor",0.48947,1.28,0.19,258,1,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, SNX.5422, ganetespib",0.721246399047171,0,FALSE
+"H1975","Pearson.est","JAK inhibitor",-0.39369,-1.02,0.395,1177,0.969,"CEP.33779, pacritinib, TG.101348, AZD1480, TG.02, filgotinib, lestaurtinib",0.40340290437354,0.0136762229492347,FALSE
+"H1975","Pearson.est","KIT inhibitor",-0.28998,-0.737,0.746,1102,0.932,"imatinib, lenvatinib, KI.8751, telatinib, vatalanib, sunitinib, masitinib",0.127261172527331,0.0305840876460186,FALSE
+"H1975","Pearson.est","MDM inhibitor",-0.2862,-0.729,0.75,1013,0.896,"nutlin.3, CGM097, RITA",0.1249387366083,0.0476919903378748,FALSE
+"H1975","Pearson.est","MEK inhibitor",-0.30813,-0.802,0.688,1182,0.878,"refametinib, nobiletin, BIX.02188, MEK162, arctigenin",0.162411561764489,0.0565054840938974,FALSE
+"H1975","Pearson.est","MET inhibitor",-0.63959,-1.66,0.0471,1153,0.331,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.3269790928711,0.480172006224281,FALSE
+"H1975","Pearson.est","microtubule inhibitor",0.43555,1.11,0.32,149,1,"estramustine.phosphate, triclabendazole",0.494850021680094,0,FALSE
+"H1975","Pearson.est","mTOR inhibitor",0.69201,1.81,0.021,187,0.563,"deforolimus, PI.103, AZD8055, PKI.179, torin.1, everolimus, temsirolimus, NVP.BEZ235, LY3023414, PP242, MLN0128, AZD2014, sirolimus, GDC.0980, torin.2, WYE.125132",1.67778070526608,0.249491605148654,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",-0.41013,-1.06,0.374,1221,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.42712839779952,0,FALSE
+"H1975","Pearson.est","opioid receptor agonist",-0.45098,-1.15,0.301,1266,1,"ADL5859, salvinorin.a",0.521433504406157,0,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",-0.20305,-0.53,0.971,1298,0.987,"skepinone.l",0.0127807700919951,0.00568284733036327,FALSE
+"H1975","Pearson.est","PARP inhibitor",-0.54853,-1.43,0.126,980,0.6,"olaparib, AZD2461, niraparib, AG.14361, talazoparib",0.899629454882437,0.221848749616356,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.36807,-0.939,0.504,1019,0.808,"crenolanib, ponatinib, nintedanib, imatinib, lenvatinib, KI.8751, axitinib, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.297569463554475,0.0925886392254138,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",-0.40778,-1.08,0.329,1241,1,"CID.5458317, menadione, alexidine",0.482804102050026,0,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",0.24375,0.646,0.905,164,0.928,"papaverine, enoximone",0.0433514207947967,0.0324520237811379,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.3678,0.936,0.542,476,0.934,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, voxtalisib, SB.2343, ZSTK.474, buparlisib, PF.04691502, PI3K.IN.2, PF.05212384, PI.828, CUDC.907",0.266000713461613,0.0296531237699066,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.34906,0.92,0.534,945,0.886,"HMN.214, BI.2536, volasertib, NMS.1286937, GSK461364, rigosertib, GW.843682X",0.272458742971444,0.0525662781129492,FALSE
+"H1975","Pearson.est","potassium channel blocker",0.58388,1.51,0.0742,464,0.755,"ML133, ibutilide, dofetilide, oleoylethanolamide, mepivacaine",1.12959609472097,0.122053048370812,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",-0.34172,-0.873,0.571,1085,0.827,"S26948, clofibrate, fenofibrate",0.243363891754152,0.0824944904474534,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.65785,-1.71,0.037,1170,0.306,"dienogest, norgestrel, melengestrol.acetate, danazol, nomegestrol.acetate, norethindrone.acetate",1.431798275933,0.51427857351842,FALSE
+"H1975","Pearson.est","proteasome inhibitor",0.3742,0.971,0.464,198,0.954,"ONX.0914, MG.132",0.333482019445119,0.0204516252959049,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.28551,0.738,0.772,400,0.918,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, azomycin..2.nitroimidazole.",0.112382699664264,0.0371573187987575,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",-0.31976,-0.831,0.671,1354,0.852,"CP.724714, rheochrysidin",0.173277479831008,0.0695604052332999,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.46132,1.18,0.283,339,1,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.54821356447571,0,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",-0.3526,-0.923,0.533,1384,0.811,"sunitinib",0.273272790973428,0.090979145788844,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.31175,0.813,0.69,71,0.856,"LE.135",0.161150909262745,0.0675262353228468,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.36384,-0.951,0.491,1442,0.845,"pentostatin",0.308918507877032,0.0731432910503077,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.67638,-1.75,0.0264,1327,0.306,"zolmitriptan, ipsapirone, aripiprazole",1.57839607313017,0.51427857351842,FALSE
+"H1975","Pearson.est","serotonin receptor antagonist",-0.38782,-1.03,0.395,1283,1,"paliperidone, lurasidone, aripiprazole",0.40340290437354,0,FALSE
+"H1975","Pearson.est","sodium channel blocker",0.33324,0.853,0.605,464,0.874,"brivaracetam, ajmaline, butamben, cibenzoline, mexiletine, mepivacaine",0.218244625347531,0.058488567365597,FALSE
+"H1975","Pearson.est","src inhibitor",-0.36515,-0.965,0.481,1056,0.883,"bosutinib, PP.1, PP.2, masitinib",0.317854923626168,0.0540392964224314,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",0.36424,0.949,0.508,10,0.954,"chlormidazole",0.294136287716081,0.0204516252959049,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",-0.52052,-1.39,0.141,969,0.62,"adaprev, repsox, SB.431542, D.4476, SB.525334",0.85078088734462,0.207608310501746,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.31521,0.799,0.7,586,0.85,"ftorafur, raltitrexed, doxifluridine, carmofur",0.154901959985743,0.0705810742857073,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",0.26911,0.701,0.812,171,0.916,"mitoxantrone, doxorubicin, idarubicin, exatecan.mesylate",0.0904439707588247,0.0381045263321496,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",0.36538,0.931,0.534,530,0.903,"mebendazole, epothilone.b, oxibendazole, BNC105, vinorelbine, CYT.997, fenbendazole, taltobulin, indibulin, verubulin, dolastatin.10, plinabulin, podophyllotoxin, parbendazole, KX2.391",0.272458742971444,0.0443122496864942,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",0.23559,0.598,0.935,437,0.948,"AV.412, dasatinib, NVP.TAE226, bafetinib, mubritinib, sorafenib, GTP.14564, apatinib, tyrphostin.A9, tivantinib",0.0291883891274822,0.0231916626619338,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",0.1975,0.514,0.975,125,0.974,"BMS.690514, OSI.930, XL.647, SAR131675",0.0109953843014632,0.0114410431213845,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.5536,1.42,0.115,253,0.888,"ercalcitriol, calcitriol, maxacalcitol",0.939302159646388,0.051587034221399,FALSE
+"HCC78","Pearson.est","EGFR inhibitor",0.341,0.884,0.568,321,0.943,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, WZ.3146, BMS.690514, XL.647, canertinib, gefitinib, AST.1306, BIBX.1382, brigatinib, PD.168393, icotinib, afatinib, BIBU.1361",0.245651664288981,0.0254883072626717,FALSE
+"HCC78","Pearson.est","Abl kinase inhibitor",-0.3141,-0.797,0.671,1062,0.866,"bosutinib, ponatinib, imatinib, KW.2449, flumatinib",0.173277479831008,0.0624821079826534,FALSE
+"HCC78","Pearson.est","acetylcholine receptor agonist",0.22299,0.571,0.942,356,1,"xanomeline, oxiracetam",0.0259490972071227,0,FALSE
+"HCC78","Pearson.est","acetylcholine receptor antagonist",-0.73108,-1.88,0.0125,1075,0.145,"darifenacin, hyoscyamine, dicycloverine, methscopolamine, iododexetimide",1.90308998699194,0.838631997765025,TRUE
+"HCC78","Pearson.est","adenosine receptor antagonist",-0.38965,-1,0.44,1199,0.788,"sulmazole, istradefylline",0.356547323513813,0.103473782510445,FALSE
+"HCC78","Pearson.est","adrenergic receptor agonist",-0.4071,-1.03,0.423,858,0.758,"isoxsuprine, clenbuterol, midodrine, A61603, terbutaline, xylazine, ritodrine, oxymetazoline, methyldopa, norepinephrine, isoetharine",0.373659632624958,0.120330794367946,FALSE
+"HCC78","Pearson.est","adrenergic receptor antagonist",0.34413,0.894,0.54,193,1,"practolol, propranolol, idazoxan, vincamine",0.267606240177031,0,FALSE
+"HCC78","Pearson.est","AKT inhibitor",0.38476,1,0.448,421,1,"ONC201, MK.2206, triciribine, palomid.529, AT7867, GSK2110183",0.348721986001856,0,FALSE
+"HCC78","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.45139,-1.16,0.293,1254,0.709,"alectinib, DMH1, CEP.37440",0.533132379645891,0.149353764816933,FALSE
+"HCC78","Pearson.est","androgen receptor antagonist",-0.6846,-1.76,0.0239,1017,0.215,"nilutamide, bicalutamide, flutamide, enzalutamide, cyproterone.acetate",1.62160209905186,0.667561540084395,TRUE
+"HCC78","Pearson.est","antioxidant",-0.45091,-1.16,0.288,784,0.709,"taurine, mesna, rutin, benfotiamine, trolox",0.540607512240769,0.149353764816933,FALSE
+"HCC78","Pearson.est","AP inhibitor",0.65078,1.69,0.0364,75,0.633,"birinapant, GDC.0152",1.43889861635094,0.198596289982645,FALSE
+"HCC78","Pearson.est","ATPase inhibitor",0.47025,1.23,0.23,264,1,"k.strophanthidin, oligomycin.a, ouabain, evodiamine, blebbistatin....",0.638272163982407,0,FALSE
+"HCC78","Pearson.est","Aurora kinase inhibitor",0.23853,0.626,0.894,517,0.987,"MK.5108, MK.8745, barasertib.HQPA, barasertib, MLN.8054, alisertib, ENMD.2076, PF.03814735, CCT137690, ZM.447439, danusertib",0.0486624812040823,0.00568284733036327,FALSE
+"HCC78","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.48588,-1.25,0.212,1359,0.774,"azalomycin.b, dirithromycin",0.673664139071249,0.111259039317107,FALSE
+"HCC78","Pearson.est","bacterial DNA gyrase inhibitor",0.31691,0.846,0.64,418,0.931,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.193820026016113,0.0310503190186574,FALSE
+"HCC78","Pearson.est","BCL inhibitor",-0.38284,-0.963,0.5,1408,0.805,"gossypol, ABT.737",0.301029995663981,0.0942041196321315,FALSE
+"HCC78","Pearson.est","Bcr.Abl kinase inhibitor",-0.25988,-0.673,0.856,1062,0.919,"bosutinib, ponatinib, imatinib, flumatinib",0.0675262353228468,0.0366844886138887,FALSE
+"HCC78","Pearson.est","benzodiazepine receptor agonist",0.39574,1.05,0.387,147,1,"ivermectin, gamma.aminobutyric.acid, bentazepam, ZK.93423",0.412289034981089,0,FALSE
+"HCC78","Pearson.est","bromodomain inhibitor",-0.58823,-1.5,0.0734,1031,0.479,"JQ1...., bromosporine, I.BET151, PFI.1",1.13430394008393,0.319664486585437,FALSE
+"HCC78","Pearson.est","calcium channel blocker",-0.41531,-1.06,0.385,1278,0.786,"SR.33805, efonidipine.monoethanolate, mibefradil",0.414539270491499,0.104577453960592,FALSE
+"HCC78","Pearson.est","CC chemokine receptor antagonist",-0.23916,-0.61,0.902,965,0.948,"SB.225002, navarixin, PF.04136309",0.0447934624580583,0.0231916626619338,FALSE
+"HCC78","Pearson.est","CDK inhibitor",-0.35257,-0.893,0.565,970,0.835,"palbociclib, PHA.848125, R547, AZD5438, indirubin, abemaciclib, ribociclib, BMS.265246, JNJ.7706621, TG.02",0.247951552180562,0.0783135245163979,FALSE
+"HCC78","Pearson.est","CHK inhibitor",-0.53752,-1.43,0.103,1120,0.568,"SCH.900776, AZD7762, SB.218078",0.987162775294828,0.245651664288981,FALSE
+"HCC78","Pearson.est","cyclooxygenase inhibitor",-0.35196,-0.919,0.519,976,0.837,"indoprofen, amfenac, curcumin, phenazone, AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.284832642151542,0.07727454200674,FALSE
+"HCC78","Pearson.est","cytochrome P450 inhibitor",0.37844,0.997,0.459,398,0.963,"PF.4981517, morin, eplerenone",0.338187314462739,0.0163737128754655,FALSE
+"HCC78","Pearson.est","DNA alkylating agent",-0.38433,-0.989,0.473,1050,0.781,"melphalan, TH.302, satraplatin, carmustine, streptozotocin, cyclophosphamide, temozolomide",0.325138859262188,0.1073489661227,FALSE
+"HCC78","Pearson.est","DNA inhibitor",-0.21682,-0.546,0.944,1366,0.977,"nithiamide, pibenzimol",0.025028005701931,0.0101054362812269,FALSE
+"HCC78","Pearson.est","DNA methyltransferase inhibitor",0.58329,1.55,0.0787,543,0.815,"azacitidine, fdcyd, SGI.1027, decitabine",1.10402526764094,0.0888423912600234,FALSE
+"HCC78","Pearson.est","DNA polymerase inhibitor",0.31726,0.844,0.622,182,0.894,"foscarnet, cidofovir, cephalomannine",0.206209615309181,0.0486624812040823,FALSE
+"HCC78","Pearson.est","DNA synthesis inhibitor",-0.32156,-0.82,0.629,1362,0.872,"altretamine, enocitabine",0.201349354554731,0.0594835150674328,FALSE
+"HCC78","Pearson.est","dopamine receptor antagonist",-0.40342,-1.04,0.394,1196,0.796,"mesoridazine, remoxipride, ziprasidone, paliperidone, lurasidone, amisulpride",0.404503778174426,0.0990869322623309,FALSE
+"HCC78","Pearson.est","estrogen receptor agonist",-0.3295,-0.852,0.622,1224,0.861,"estrone, erteberel",0.206209615309181,0.0649968485463452,FALSE
+"HCC78","Pearson.est","estrogen receptor antagonist",-0.7845,-2.05,0.00186,1228,0.0497,"raloxifene, danazol, fulvestrant, tamoxifen",2.73048705578208,1.30364361126667,TRUE
+"HCC78","Pearson.est","FGFR inhibitor",-0.46186,-1.19,0.28,1083,0.764,"lenvatinib, MK.2461, nintedanib, lucitanib",0.552841968657781,0.11690664142431,FALSE
+"HCC78","Pearson.est","FLT3 inhibitor",-0.42337,-1.07,0.381,1097,0.797,"ponatinib, TG.101348, quizartinib, pacritinib, KW.2449, TG.02, sunitinib, lestaurtinib",0.419075024324381,0.0985416786038876,FALSE
+"HCC78","Pearson.est","glucocorticoid receptor agonist",-0.29868,-0.772,0.732,1027,0.885,"rimexolone, flumethasone, prednisolone, prednisolone.acetate, hydrocortisone, beclomethasone.dipropionate, fluticasone.propionate, piretanide, fluocinolone.acetonide, dexamethasone.acetate, flumethasone.pivalate",0.135488918941608,0.0530567293021746,FALSE
+"HCC78","Pearson.est","glutamate receptor antagonist",0.27773,0.731,0.779,225,0.915,"ACDPP, tiletamine, kynurenic.acid",0.108462542327436,0.0385789059335517,FALSE
+"HCC78","Pearson.est","glycogen synthase kinase inhibitor",0.30364,0.794,0.678,80,0.876,"CHIR.99021",0.168770306132937,0.0574958938319193,FALSE
+"HCC78","Pearson.est","growth factor receptor inhibitor",-0.60759,-1.56,0.0857,954,0.411,"AZD3463, PHA.848125, GSK1904529A, GW.441756, GSK1838705A, lestaurtinib",1.0670191780768,0.386158178123931,FALSE
+"HCC78","Pearson.est","HCV inhibitor",0.40292,1.05,0.381,91,1,"daclatasvir",0.419075024324381,0,FALSE
+"HCC78","Pearson.est","HDAC inhibitor",0.45832,1.22,0.226,256,1,"chidamide, nexturastat.a, panobinostat, NSC.3852, belinostat, scriptaid, ACY.1215, SB.939, entinostat, mocetinostat",0.645891560852599,0,FALSE
+"HCC78","Pearson.est","histamine receptor antagonist",-0.25853,-0.676,0.835,1230,0.936,"epinastine, tiotidine, ebastine, BF2.649",0.0783135245163979,0.0287241512618947,FALSE
+"HCC78","Pearson.est","HMGCR inhibitor",0.39262,1.04,0.383,222,1,"atorvastatin, simvastatin",0.416801226031377,0,FALSE
+"HCC78","Pearson.est","HSP inhibitor",0.44375,1.16,0.257,334,1,"BIIB021, PU.H71, NMS.E973, NVP.AUY922, ganetespib, KW.2478, SNX.2112, SNX.5422",0.590066876668705,0,FALSE
+"HCC78","Pearson.est","JAK inhibitor",-0.39908,-1.03,0.405,1105,0.758,"TG.101348, CEP.33779, filgotinib, pacritinib, AZD1480, TG.02, lestaurtinib",0.392544976785331,0.120330794367946,FALSE
+"HCC78","Pearson.est","KIT inhibitor",-0.3613,-0.947,0.522,1083,0.811,"lenvatinib, imatinib, KI.8751, telatinib, vatalanib, sunitinib, masitinib",0.282329496997738,0.090979145788844,FALSE
+"HCC78","Pearson.est","MDM inhibitor",0.31969,0.826,0.656,987,0.891,"serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3, RITA",0.18309616062434,0.0501222959631252,FALSE
+"HCC78","Pearson.est","MEK inhibitor",-0.29832,-0.771,0.745,1175,0.865,"refametinib, MEK162, BIX.02188, nobiletin, arctigenin",0.127843727251707,0.0629838925351858,FALSE
+"HCC78","Pearson.est","MET inhibitor",-0.79985,-2.06,0,1287,0.0973,"INC.280, PHA.665752, NVP.BVU972, AMG458",Inf,1.01188715973165,TRUE
+"HCC78","Pearson.est","microtubule inhibitor",0.38032,1,0.423,163,1,"estramustine.phosphate, triclabendazole",0.373659632624958,0,FALSE
+"HCC78","Pearson.est","mTOR inhibitor",0.67089,1.77,0.0277,207,0.795,"deforolimus, PI.103, torin.1, AZD8055, PKI.179, NVP.BEZ235, PP242, LY3023414, everolimus, MLN0128, temsirolimus, AZD2014, sirolimus, SB.2343, GDC.0980, WYE.125132",1.55752023093555,0.0996328713435297,FALSE
+"HCC78","Pearson.est","NFkB pathway inhibitor",-0.46883,-1.21,0.236,1044,0.761,"IKK.2.inhibitor.V, bortezomib, curcumin, bindarit, parthenolide, Ro.106.9920, betulinic.acid",0.627087997029893,0.118615343229427,FALSE
+"HCC78","Pearson.est","opioid receptor agonist",-0.42735,-1.1,0.348,1203,0.805,"ADL5859, salvinorin.a",0.458420756053419,0.0942041196321315,FALSE
+"HCC78","Pearson.est","p38 MAPK inhibitor",-0.30785,-0.799,0.696,1320,0.885,"skepinone.l",0.157390760389438,0.0530567293021746,FALSE
+"HCC78","Pearson.est","PARP inhibitor",-0.59525,-1.56,0.0624,947,0.411,"PJ.34, niraparib, olaparib, AZD2461, AG.14361, talazoparib",1.20481541031758,0.386158178123931,FALSE
+"HCC78","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.45176,-1.16,0.282,1083,0.709,"lenvatinib, ponatinib, imatinib, axitinib, nintedanib, KI.8751, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.549750891680639,0.149353764816933,FALSE
+"HCC78","Pearson.est","phosphatase inhibitor",-0.3398,-0.864,0.603,1177,0.864,"CID.5458317, menadione, alexidine",0.219682687859849,0.0634862575211067,FALSE
+"HCC78","Pearson.est","phosphodiesterase inhibitor",-0.20975,-0.542,0.973,1154,0.96,"trequinsin, GSK256066, avanafil",0.0118871597316481,0.0177287669604316,FALSE
+"HCC78","Pearson.est","PI3K inhibitor",0.35322,0.926,0.527,169,1,"PI.103, PKI.179, NVP.BEZ235, LY3023414, BGT226, SB.2343, GDC.0980",0.278189384787453,0,FALSE
+"HCC78","Pearson.est","PLK inhibitor",-0.32105,-0.825,0.636,847,0.886,"rigosertib, volasertib, GSK461364, NMS.1286937, GW.843682X",0.196542884351586,0.0525662781129492,FALSE
+"HCC78","Pearson.est","potassium channel blocker",0.56481,1.51,0.096,408,0.725,"ibutilide, ML133, oleoylethanolamide, dofetilide",1.01772876696043,0.139661993429006,FALSE
+"HCC78","Pearson.est","PPAR receptor agonist",-0.25675,-0.662,0.866,1364,0.913,"fenofibrate",0.0624821079826534,0.039529222465701,FALSE
+"HCC78","Pearson.est","progesterone receptor agonist",-0.49519,-1.28,0.189,1130,0.76,"dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",0.723538195826756,0.119186407719209,FALSE
+"HCC78","Pearson.est","proteasome inhibitor",0.35436,0.937,0.5,179,1,"ONX.0914, MG.132",0.301029995663981,0,FALSE
+"HCC78","Pearson.est","protein synthesis inhibitor",0.33061,0.864,0.6,358,0.936,"clofoctol, cycloheximide, chloramphenicol.palmitate, brefeldin.a, azomycin..2.nitroimidazole., methacycline, thiostrepton",0.221848749616356,0.0287241512618947,FALSE
+"HCC78","Pearson.est","protein tyrosine kinase inhibitor",-0.41083,-1.07,0.377,1282,0.797,"BMS.599626, CP.724714, rheochrysidin",0.423658649794207,0.0985416786038876,FALSE
+"HCC78","Pearson.est","RAF inhibitor",0.24771,0.641,0.909,148,1,"SB.590885, vemurafenib",0.0414361167780325,0,FALSE
+"HCC78","Pearson.est","RET tyrosine kinase inhibitor",-0.50005,-1.28,0.202,1401,0.76,"sunitinib",0.694648630553376,0.119186407719209,FALSE
+"HCC78","Pearson.est","retinoid receptor agonist",0.30978,0.815,0.628,50,0.876,"LE.135",0.202040356262804,0.0574958938319193,FALSE
+"HCC78","Pearson.est","ribonucleotide reductase inhibitor",-0.35043,-0.894,0.551,1438,0.858,"pentostatin",0.258848401148215,0.0665127121512946,FALSE
+"HCC78","Pearson.est","serotonin receptor agonist",-0.69102,-1.79,0.0179,1338,0.216,"zolmitriptan, ipsapirone, aripiprazole",1.74714696902011,0.665546248849069,TRUE
+"HCC78","Pearson.est","serotonin receptor antagonist",-0.4855,-1.23,0.231,1210,0.766,"ziprasidone, RS.16566, paliperidone, lurasidone, aripiprazole",0.636388020107856,0.115771230367396,FALSE
+"HCC78","Pearson.est","sodium channel blocker",0.20848,0.545,0.968,446,0.989,"brivaracetam, cibenzoline, ajmaline, mexiletine, butamben",0.0141246426916063,0.0048037084028206,FALSE
+"HCC78","Pearson.est","src inhibitor",-0.50457,-1.29,0.199,1062,0.864,"bosutinib, TG.100572, PP.1, PP.2, masitinib",0.701146923590293,0.0634862575211067,FALSE
+"HCC78","Pearson.est","sterol demethylase inhibitor",0.34269,0.888,0.571,19,0.983,"chlormidazole",0.243363891754152,0.00744648216786438,FALSE
+"HCC78","Pearson.est","TGF beta receptor inhibitor",-0.63175,-1.61,0.0584,1021,0.433,"SB.525334, repsox, SB.431542, adaprev, D.4476",1.2335871528876,0.363512103646635,FALSE
+"HCC78","Pearson.est","thymidylate synthase inhibitor",0.20735,0.544,0.955,1149,0.959,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.0199966284162537,0.0181813928293364,FALSE
+"HCC78","Pearson.est","topoisomerase inhibitor",0.27905,0.742,0.77,239,0.931,"doxorubicin, mitoxantrone, idarubicin, amsacrine, epirubicin, exatecan.mesylate",0.113509274827518,0.0310503190186574,FALSE
+"HCC78","Pearson.est","tubulin polymerization inhibitor",0.38816,1.02,0.411,283,1,"mebendazole, BNC105, vinorelbine, epothilone.b, CYT.997, oxibendazole, verubulin, indibulin, fenbendazole, taltobulin",0.386158178123931,0,FALSE
+"HCC78","Pearson.est","tyrosine kinase inhibitor",-0.27498,-0.71,0.789,1282,0.913,"BMS.599626, CP.724714, rheochrysidin, sunitinib",0.10292299679058,0.039529222465701,FALSE
+"HCC78","Pearson.est","VEGFR inhibitor",-0.27872,-0.716,0.805,1083,0.926,"lenvatinib, axitinib, MK.2461, nintedanib, TG.100572, tivozanib, KI.8751, telatinib, lucitanib, vatalanib, foretinib, sunitinib",0.0942041196321315,0.0333890133180656,FALSE
+"HCC78","Pearson.est","vitamin D receptor agonist",0.42489,1.12,0.312,379,1,"ercalcitriol, calcitriol, maxacalcitol",0.505845405981557,0,FALSE
+"H2126","Pearson.est","EGFR inhibitor",0.46772,1.18,0.275,400,1,"CUDC.101, ARRY.334543, BMS.690514, tyrphostin.AG.1478, erlotinib, XL.647, canertinib, brigatinib, WZ.3146, gefitinib, BIBU.1361, AST.1306, PD.168393, icotinib, BIBX.1382, afatinib, rociletinib, pelitinib, AZD8931, lapatinib, osimertinib, vandetanib",0.560667306169737,0,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",0.39366,1,0.441,171,0.889,"dasatinib, metatinib, bafetinib",0.355561410532161,0.0510982390297863,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",0.28109,0.702,0.821,474,0.899,"xanomeline, oxiracetam, tremorine",0.0856568428805592,0.0462403082667712,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",-0.73604,-1.92,0.00952,1282,0.133,"dicycloverine, methscopolamine, iododexetimide",2.02136305161553,0.876148359032914,TRUE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.3705,-0.973,0.477,1432,0.9,"istradefylline",0.321481620959886,0.0457574905606751,FALSE
+"H2126","Pearson.est","adrenergic receptor agonist",-0.39197,-1.02,0.412,1256,0.882,"ritodrine, methyldopa, norepinephrine, isoetharine",0.385102783966865,0.0545314148681803,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",0.35561,0.902,0.564,194,0.798,"practolol, idazoxan, propranolol, vincamine",0.248720896016658,0.0979971086492706,FALSE
+"H2126","Pearson.est","AKT inhibitor",0.45184,1.17,0.296,402,1,"triciribine, MK.2206, palomid.529, AT7867, ONC201",0.528708288941061,0,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.21619,-0.579,0.925,1176,0.987,"alectinib, CEP.37440, DMH1",0.0338582672609674,0.00568284733036327,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",-0.72463,-1.88,0.00457,1177,0.131,"flutamide, nilutamide, enzalutamide, cyproterone.acetate",2.34008379993015,0.882728704344236,TRUE
+"H2126","Pearson.est","antioxidant",-0.60913,-1.69,0.0483,1109,0.263,"benfotiamine, trolox",1.31605286924849,0.580044251510242,FALSE
+"H2126","Pearson.est","AP inhibitor",0.62122,1.55,0.0651,75,0.696,"birinapant, GDC.0152",1.18641901143181,0.157390760389438,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.4408,1.13,0.316,420,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873, thonzonium",0.500312917381596,0,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.40132,1.03,0.407,440,0.905,"MK.5108, barasertib, alisertib, barasertib.HQPA, MK.8745, ENMD.2076, ZM.447439, CCT137690, PF.03814735, danusertib, SNS.314",0.39040559077478,0.0433514207947967,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.28198,0.722,0.793,188,0.919,"tedizolid, azithromycin",0.100726812682396,0.0366844886138887,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.41172,1.04,0.376,343,0.928,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.424812155072339,0.0324520237811379,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.37377,0.972,0.478,327,0.838,"oridonin, TW.37, obatoclax, HA14.1, venetoclax",0.320572103387881,0.0767559813697235,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.43545,1.1,0.343,171,0.936,"dasatinib, metatinib, bafetinib",0.464705879957229,0.0287241512618947,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",0.43451,1.09,0.334,104,0.907,"gamma.aminobutyric.acid, ZK.93423, ivermectin, bentazepam",0.476253533188435,0.0423927129399047,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",-0.38667,-1.02,0.396,1157,0.882,"I.BET151, PFI.1",0.402304814074488,0.0545314148681803,FALSE
+"H2126","Pearson.est","calcium channel blocker",-0.31465,-0.834,0.643,1212,0.958,"efonidipine.monoethanolate, SR.33805, mibefradil",0.191789027075778,0.0186344909214556,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.29142,0.74,0.766,464,0.916,"UNBS.5162, ZK811752, MK.0812, RS.504393",0.115771230367396,0.0381045263321496,FALSE
+"H2126","Pearson.est","CDK inhibitor",-0.17111,-0.453,0.993,244,0.991,"alvocidib, kenpaullone, NU6027, CR8..R., P276.00, AT.7519, aminopurvalanol.a, dinaciclib, BMS.387032, indisulam, PHA.793887, palbociclib, PHA.848125, AZD5438, arcyriaflavin.a, R547, abemaciclib, indirubin, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.00305075150461883,0.00392634551472468,FALSE
+"H2126","Pearson.est","CHK inhibitor",-0.50799,-1.35,0.151,1179,0.674,"SCH.900776, AZD7762, SB.218078",0.821023052706831,0.17134010346468,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.42754,-1.15,0.309,1257,0.918,"acetylsalicylsalicylic.acid, piroxicam, FR.122047, AM.404, tryptanthrin, naproxen",0.510041520575165,0.0371573187987575,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",0.56089,1.43,0.119,205,0.805,"PF.4981517, morin, eplerenone",0.924453038607469,0.0942041196321315,FALSE
+"H2126","Pearson.est","DNA alkylating agent",-0.27459,-0.719,0.814,984,0.965,"mitomycin.c, carmustine, streptozotocin, melphalan, satraplatin, cyclophosphamide, temozolomide",0.0893755951107988,0.0154726866562074,FALSE
+"H2126","Pearson.est","DNA inhibitor",-0.23948,-0.618,0.879,1361,1,"pibenzimol, nithiamide",0.0560111249262281,0,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",0.64372,1.65,0.0355,412,0.79,"SGI.1027, decitabine, azacitidine, fdcyd",1.44977164694491,0.102372908709559,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",0.42296,1.1,0.329,243,0.936,"foscarnet, cephalomannine, idoxuridine, cidofovir",0.482804102050026,0.0287241512618947,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",-0.33039,-0.882,0.574,1384,0.934,"altretamine, enocitabine",0.241088107602027,0.0296531237699066,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.38029,-0.979,0.467,1100,0.932,"mesoridazine, nemonapride, ziprasidone, paliperidone, remoxipride, amisulpride, lurasidone",0.330683119433888,0.0305840876460186,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",-0.3096,-0.814,0.656,1089,0.928,"ethinyl.estradiol, estrone, erteberel",0.18309616062434,0.0324520237811379,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",-0.7989,-2.08,0.00228,1288,0.105,"danazol, raloxifene, fulvestrant, tamoxifen",2.64206515299955,0.978810700930062,TRUE
+"H2126","Pearson.est","FGFR inhibitor",-0.25869,-0.67,0.862,372,1,"orantinib, AZD4547, regorafenib, erdafitinib, PD.173074, dovitinib, nintedanib, MK.2461, lucitanib, lenvatinib",0.0644927341752872,0,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",-0.30279,-0.815,0.64,1114,0.96,"KW.2449, pacritinib, TG.101348, quizartinib, TG.02, sunitinib, lestaurtinib",0.193820026016113,0.0177287669604316,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",-0.37715,-1.02,0.412,971,0.882,"flumethasone, fludroxycortide, halcinonide, triamcinolone.acetonide, prednisolone, rimexolone, desonide, triamcinolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.385102783966865,0.0545314148681803,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",0.39358,0.991,0.458,189,0.87,"ACDPP, kynurenic.acid, tiletamine",0.339134521996131,0.0604807473813815,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",0.36233,0.918,0.543,29,0.853,"CHIR.99021",0.265200170411153,0.069050968832477,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",-0.55766,-1.46,0.111,1359,0.522,"GW.441756, lestaurtinib",0.954677021213343,0.282329496997738,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.3693,0.933,0.538,49,0.886,"daclatasvir",0.269217724333611,0.0525662781129492,FALSE
+"H2126","Pearson.est","HDAC inhibitor",0.45539,1.16,0.267,308,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, M.344, ACY.1215, entinostat, resminostat",0.573488738635425,0,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",-0.24492,-0.636,0.872,1130,1,"terfenadine, tiotidine, ebastine, ranitidine, BF2.649, epinastine",0.0594835150674328,0,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",0.35417,0.915,0.548,224,0.829,"atorvastatin, simvastatin",0.261219441515631,0.0814454694497265,FALSE
+"H2126","Pearson.est","HSP inhibitor",0.57332,1.43,0.112,203,0.805,"BIIB021, NMS.E973, PU.H71, SNX.5422, SNX.2112, NVP.AUY922, ganetespib",0.950781977329818,0.0942041196321315,FALSE
+"H2126","Pearson.est","JAK inhibitor",-0.31846,-0.835,0.642,1141,0.994,"pacritinib, TG.101348, filgotinib, CEP.33779, AZD1480, TG.02, lestaurtinib",0.192464971931147,0.00261361560268669,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.31706,0.81,0.701,73,0.854,"midostaurin, OSI.930, dasatinib",0.154281982033341,0.068542129310995,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.2337,-0.607,0.9,337,0.991,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.0457574905606751,0.00392634551472468,FALSE
+"H2126","Pearson.est","MEK inhibitor",-0.2221,-0.576,0.932,1154,0.963,"refametinib, nobiletin, MEK162, BIX.02188, arctigenin",0.0305840876460186,0.0163737128754655,FALSE
+"H2126","Pearson.est","MET inhibitor",-0.57195,-1.5,0.0876,1108,0.514,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.05749589383192,0.289036881004724,FALSE
+"H2126","Pearson.est","microtubule inhibitor",0.35119,0.906,0.531,560,0.817,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel, D.64131",0.274905478918531,0.0877779434675845,FALSE
+"H2126","Pearson.est","mTOR inhibitor",0.67791,1.75,0.0125,389,0.856,"deforolimus, PI.103, AZD8055, everolimus, PKI.179, NVP.BEZ235, temsirolimus, torin.1, MLN0128, AZD2014, LY3023414, PP242, torin.2, GDC.0980, WYE.125132, sirolimus, SB.2343, PF.04691502, palomid.529, ku.0063794, voxtalisib",1.90308998699194,0.0675262353228468,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.3568,-0.917,0.545,1151,0.899,"tyloxapol, Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.263603497723358,0.0462403082667712,FALSE
+"H2126","Pearson.est","opioid receptor agonist",-0.41929,-1.09,0.346,1279,1,"ADL5859, salvinorin.a",0.460923901207223,0,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",0.20452,0.522,0.976,163,0.97,"SB.239063",0.0105501823333082,0.0132282657337552,FALSE
+"H2126","Pearson.est","PARP inhibitor",-0.48365,-1.28,0.209,884,0.758,"E7449, niraparib, AZD2461, olaparib, AG.14361, talazoparib",0.679853713888946,0.120330794367946,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30197,-0.805,0.663,1169,0.913,"axitinib, lenvatinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.178486471595227,0.039529222465701,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.26838,0.679,0.852,174,0.905,"AS.1949490, sodium.stibogluconate",0.0695604052332999,0.0433514207947967,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",0.31413,0.786,0.698,228,0.869,"papaverine, enoximone, EMD.53998",0.156144577376839,0.0609802235513335,FALSE
+"H2126","Pearson.est","PI3K inhibitor",0.38658,0.982,0.469,513,0.851,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, GDC.0980, SB.2343, buparlisib, PF.04691502, ZSTK.474, voxtalisib, PI.828, PI3K.IN.2, CUDC.907, PF.05212384",0.328827157284917,0.0700704399154121,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.39695,1.02,0.434,876,0.885,"HMN.214, BI.2536, volasertib, rigosertib, NMS.1286937, GSK461364, GW.843682X",0.362510270487489,0.0530567293021746,FALSE
+"H2126","Pearson.est","potassium channel blocker",0.61348,1.56,0.0627,416,0.881,"ML133, ibutilide, mepivacaine, oleoylethanolamide, dofetilide",1.20273245916928,0.0550240915879521,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",-0.34702,-0.922,0.514,1418,0.973,"fenofibrate",0.289036881004724,0.0118871597316481,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",-0.74559,-1.99,0.00233,1221,0.11,"norgestrel, dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",2.63264407897398,0.958607314841775,TRUE
+"H2126","Pearson.est","proteasome inhibitor",0.46115,1.18,0.259,426,1,"ONX.0914, MG.132, carfilzomib, delanzomib",0.586700235918748,0,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.24022,0.612,0.924,465,0.954,"clofoctol, cycloheximide, thiostrepton, puromycin, brefeldin.a, azomycin..2.nitroimidazole., methacycline",0.0343280287798933,0.0204516252959049,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",0.32569,0.82,0.654,332,0.862,"AV.412, NVP.TAE226, mubritinib, tyrphostin.A9",0.184422251675733,0.0644927341752872,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.48858,1.25,0.202,353,1,"SB.590885, vemurafenib, LGX818, dabrafenib, sorafenib, AZ.628",0.694648630553376,0,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",-0.30117,-0.783,0.694,1374,0.921,"sunitinib",0.158640529545145,0.0357403698031511,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.33427,0.862,0.62,92,0.843,"LE.135",0.207608310501746,0.0741724253752577,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",-0.39037,-1.03,0.395,1442,1,"pentostatin",0.40340290437354,0,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",-0.67538,-1.8,0.0232,1314,0.175,"ipsapirone, zolmitriptan, aripiprazole",1.6345120151091,0.756961951313706,TRUE
+"H2126","Pearson.est","serotonin receptor antagonist",-0.39527,-1.07,0.358,1382,0.992,"lurasidone, aripiprazole",0.446116973356126,0.00348832784582135,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.42317,1.1,0.337,427,0.936,"brivaracetam, ajmaline, mepivacaine, butamben, mexiletine, cibenzoline",0.472370099128661,0.0287241512618947,FALSE
+"H2126","Pearson.est","src inhibitor",-0.29537,-0.777,0.695,1258,0.902,"PP.2, masitinib",0.158015195409886,0.0447934624580583,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.37253,0.926,0.555,10,0.868,"chlormidazole",0.255707016877324,0.0614802748235081,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",-0.47494,-1.25,0.205,1034,0.754,"adaprev, SB.431542, D.4476, SB.525334",0.688246138944246,0.122628654130226,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",-0.34189,-0.919,0.533,493,0.935,"raltitrexed, ftorafur, doxifluridine, carmofur, capecitabine, trifluridine",0.273272790973428,0.0291883891274822,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.33189,0.845,0.623,574,0.846,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin, amsacrine, rubitecan, voreloxin, camptothecin, etoposide, valrubicin, epirubicin, daunorubicin, teniposide, topotecan, genz.644282",0.20551195334083,0.0726296369609765,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.41393,1.05,0.395,510,0.955,"epothilone.b, BNC105, mebendazole, oxibendazole, CYT.997, vinorelbine, taltobulin, fenbendazole, verubulin, indibulin, parbendazole, plinabulin, KX2.391, podophyllotoxin, dolastatin.10",0.40340290437354,0.0199966284162537,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",0.27987,0.713,0.82,502,0.907,"dasatinib, AV.412, bafetinib, NVP.TAE226, mubritinib, sorafenib, tyrphostin.A9, tivantinib, vandetanib, apatinib, GTP.14564, aminopurvalanol.a",0.0861861476162833,0.0423927129399047,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",0.22044,0.572,0.956,123,0.964,"BMS.690514, OSI.930, XL.647, SAR131675",0.0195421077238999,0.0159229660971692,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",0.45554,1.17,0.288,541,1,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol",0.540607512240769,0,FALSE
+"HCC827","Pearson.est","EGFR inhibitor",0.26301,0.685,0.841,309,0.858,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, WZ.3146, BMS.690514, erlotinib, XL.647, AST.1306, brigatinib, lapatinib, canertinib, AZD8931",0.0752040042020878,0.0665127121512946,FALSE
+"HCC827","Pearson.est","Abl kinase inhibitor",-0.25484,-0.667,0.851,1045,0.889,"imatinib, ponatinib, bosutinib, KW.2449, flumatinib",0.0700704399154121,0.0510982390297863,FALSE
+"HCC827","Pearson.est","acetylcholine receptor agonist",0.25287,0.662,0.858,122,0.86,"xanomeline",0.0665127121512946,0.0655015487564323,FALSE
+"HCC827","Pearson.est","acetylcholine receptor antagonist",-0.75125,-1.95,0.00589,1308,0.123,"dicycloverine, iododexetimide, methscopolamine",2.2298847052129,0.910094888560602,TRUE
+"HCC827","Pearson.est","adenosine receptor antagonist",-0.32399,-0.817,0.674,1206,0.891,"sulmazole, istradefylline",0.17134010346468,0.0501222959631252,FALSE
+"HCC827","Pearson.est","adrenergic receptor agonist",-0.39482,-1.03,0.395,1091,1,"oxymetazoline, xylazine, methyldopa, ritodrine, norepinephrine, isoetharine",0.40340290437354,0,FALSE
+"HCC827","Pearson.est","adrenergic receptor antagonist",0.28592,0.77,0.731,215,0.944,"practolol, idazoxan, propranolol, vincamine",0.13608262304214,0.025028005701931,FALSE
+"HCC827","Pearson.est","AKT inhibitor",0.35662,0.939,0.506,485,0.981,"MK.2206, triciribine, ONC201, AT7867, palomid.529, GSK2110183",0.295849483160201,0.0083309926200515,FALSE
+"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.38868,-0.998,0.448,1233,1,"alectinib, DMH1, CEP.37440",0.348721986001856,0,FALSE
+"HCC827","Pearson.est","androgen receptor antagonist",-0.70365,-1.8,0.0247,1169,0.257,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.60730304674033,0.590066876668705,FALSE
+"HCC827","Pearson.est","antioxidant",-0.55092,-1.42,0.124,1155,0.575,"benfotiamine, trolox",0.906578314837765,0.24033215531037,FALSE
+"HCC827","Pearson.est","AP inhibitor",0.66251,1.73,0.0291,59,0.497,"birinapant, GDC.0152",1.53610701101409,0.303643611266668,FALSE
+"HCC827","Pearson.est","ATPase inhibitor",0.42821,1.13,0.316,251,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, NMS.873",0.500312917381596,0,FALSE
+"HCC827","Pearson.est","Aurora kinase inhibitor",0.26592,0.702,0.801,506,0.862,"barasertib, barasertib.HQPA, MK.8745, MK.5108, alisertib, ENMD.2076, ZM.447439, CCT137690, PF.03814735, danusertib, SNS.314",0.0963674839157623,0.0644927341752872,FALSE
+"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.3691,-0.959,0.497,1334,0.868,"azalomycin.b, dirithromycin",0.303643611266668,0.0614802748235081,FALSE
+"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",0.3554,0.916,0.525,271,0.934,"lomefloxacin, finafloxacin, novobiocin",0.279840696594043,0.0296531237699066,FALSE
+"HCC827","Pearson.est","BCL inhibitor",-0.37912,-0.977,0.449,1395,0.862,"gossypol, ABT.737",0.347753658996677,0.0644927341752872,FALSE
+"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",0.31312,0.834,0.634,205,0.938,"metatinib, dasatinib, bafetinib",0.197910742118267,0.0277971616209356,FALSE
+"HCC827","Pearson.est","benzodiazepine receptor agonist",0.44134,1.19,0.271,107,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.567030709125594,0,FALSE
+"HCC827","Pearson.est","bromodomain inhibitor",-0.5128,-1.34,0.158,941,0.64,"JQ1...., bromosporine, I.BET151, PFI.1",0.801342913045577,0.193820026016113,FALSE
+"HCC827","Pearson.est","calcium channel blocker",-0.33914,-0.887,0.574,1196,0.894,"efonidipine.monoethanolate, SR.33805, mibefradil",0.241088107602027,0.0486624812040823,FALSE
+"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.25746,-0.678,0.833,371,0.896,"UNBS.5162, ZK811752, RS.504393, MK.0812, SB.225002, navarixin, PF.04136309",0.0793549985932124,0.0476919903378748,FALSE
+"HCC827","Pearson.est","CDK inhibitor",-0.27759,-0.711,0.803,1020,0.916,"AZD5438, R547, abemaciclib, indirubin, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.095284454721319,0.0381045263321496,FALSE
+"HCC827","Pearson.est","CHK inhibitor",-0.55802,-1.45,0.0985,1204,0.572,"SCH.900776, AZD7762, SB.218078",1.00656376950239,0.242603971206976,FALSE
+"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.40828,-1.03,0.415,1219,1,"acetylsalicylsalicylic.acid, AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.381951903287907,0,FALSE
+"HCC827","Pearson.est","cytochrome P450 inhibitor",0.58439,1.51,0.0838,260,0.746,"PF.4981517, morin, eplerenone",1.07675598136972,0.127261172527331,FALSE
+"HCC827","Pearson.est","DNA alkylating agent",-0.36376,-0.939,0.506,1001,0.849,"streptozotocin, TH.302, carmustine, melphalan, satraplatin, cyclophosphamide, temozolomide",0.295849483160201,0.0710923097560473,FALSE
+"HCC827","Pearson.est","DNA inhibitor",-0.25037,-0.654,0.84,1372,0.885,"pibenzimol, nithiamide",0.0757207139381184,0.0530567293021746,FALSE
+"HCC827","Pearson.est","DNA methyltransferase inhibitor",0.5783,1.51,0.0716,579,0.746,"SGI.1027, azacitidine, decitabine, fdcyd, disulfiram",1.14508697769214,0.127261172527331,FALSE
+"HCC827","Pearson.est","DNA polymerase inhibitor",0.33866,0.874,0.601,164,0.936,"foscarnet, cephalomannine, cidofovir",0.22112552799726,0.0287241512618947,FALSE
+"HCC827","Pearson.est","DNA synthesis inhibitor",-0.2745,-0.72,0.792,1297,0.927,"altretamine, enocitabine",0.101274818410506,0.0329202658555029,FALSE
+"HCC827","Pearson.est","dopamine receptor antagonist",-0.3781,-0.987,0.445,1042,0.951,"nemonapride, piperacetazine, mesoridazine, ziprasidone, remoxipride, paliperidone, amisulpride, lurasidone",0.351639989019068,0.0218194830625861,FALSE
+"HCC827","Pearson.est","estrogen receptor agonist",-0.35343,-0.92,0.537,1107,0.857,"ethinyl.estradiol, estrone, erteberel",0.270025714300444,0.0670191780768018,FALSE
+"HCC827","Pearson.est","estrogen receptor antagonist",-0.83708,-2.21,0,1301,0.0111,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.95467702121334,TRUE
+"HCC827","Pearson.est","FGFR inhibitor",-0.2733,-0.702,0.792,393,0.907,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, nintedanib, lenvatinib, MK.2461, lucitanib",0.101274818410506,0.0423927129399047,FALSE
+"HCC827","Pearson.est","FLT3 inhibitor",-0.38518,-0.979,0.463,1149,0.892,"TG.101348, pacritinib, quizartinib, KW.2449, TG.02, sunitinib, lestaurtinib",0.334419008982047,0.0496351456238769,FALSE
+"HCC827","Pearson.est","glucocorticoid receptor agonist",-0.44482,-1.16,0.28,926,0.967,"fluorometholone, ciclesonide, halobetasol.propionate, desonide, fludroxycortide, halcinonide, flumethasone, clobetasol.propionate, triamcinolone, triamcinolone.acetonide, prednisolone, rimexolone, beclomethasone.dipropionate, fluticasone.propionate, piretanide, prednisolone.acetate, fluocinolone.acetonide, hydrocortisone, dexamethasone.acetate, flumethasone.pivalate",0.552841968657781,0.0145735259169983,FALSE
+"HCC827","Pearson.est","glutamate receptor antagonist",0.36181,0.958,0.469,222,1,"ACDPP, kynurenic.acid, tiletamine, CGP.37849",0.328827157284917,0,FALSE
+"HCC827","Pearson.est","glycogen synthase kinase inhibitor",0.31447,0.842,0.625,70,0.961,"CHIR.99021",0.204119982655925,0.0172766123314547,FALSE
+"HCC827","Pearson.est","growth factor receptor inhibitor",-0.58456,-1.51,0.0741,1244,0.498,"GSK1838705A, GW.441756, lestaurtinib",1.13018179202067,0.302770657240282,FALSE
+"HCC827","Pearson.est","HCV inhibitor",0.40828,1.11,0.306,65,0.947,"daclatasvir",0.51427857351842,0.0236500209967266,FALSE
+"HCC827","Pearson.est","HDAC inhibitor",0.43518,1.12,0.311,302,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, scriptaid, SB.939, mocetinostat, ACY.1215, entinostat, M.344",0.507239610973163,0,FALSE
+"HCC827","Pearson.est","histamine receptor antagonist",-0.31435,-0.826,0.633,1037,0.925,"ICI.162846, cyproheptadine, ranitidine, terfenadine, tiotidine, ebastine, BF2.649, epinastine",0.198596289982645,0.0338582672609674,FALSE
+"HCC827","Pearson.est","HMGCR inhibitor",0.27538,0.722,0.78,262,0.89,"atorvastatin, simvastatin",0.10790539730952,0.0506099933550872,FALSE
+"HCC827","Pearson.est","HSP inhibitor",0.50456,1.31,0.18,246,1,"NMS.E973, BIIB021, PU.H71, NVP.AUY922, SNX.2112, ganetespib, SNX.5422",0.744727494896694,0,FALSE
+"HCC827","Pearson.est","JAK inhibitor",-0.43865,-1.13,0.298,1149,0.926,"TG.101348, pacritinib, CEP.33779, filgotinib, AZD1480, TG.02, lestaurtinib",0.525783735923745,0.0333890133180656,FALSE
+"HCC827","Pearson.est","KIT inhibitor",-0.30203,-0.777,0.741,1312,0.886,"vatalanib, telatinib, sunitinib, masitinib",0.130181792020672,0.0525662781129492,FALSE
+"HCC827","Pearson.est","MDM inhibitor",-0.26642,-0.685,0.854,1022,0.907,"nutlin.3, CGM097, RITA",0.068542129310995,0.0423927129399047,FALSE
+"HCC827","Pearson.est","MEK inhibitor",-0.32071,-0.825,0.628,1166,0.901,"refametinib, MEK162, nobiletin, BIX.02188, arctigenin",0.202040356262804,0.045275209020937,FALSE
+"HCC827","Pearson.est","MET inhibitor",-0.58274,-1.55,0.0758,1101,0.483,"INC.280, PHA.665752, AMG458, NVP.BVU972",1.12033079436795,0.316052869248488,FALSE
+"HCC827","Pearson.est","microtubule inhibitor",0.34902,0.913,0.538,165,0.896,"estramustine.phosphate, triclabendazole",0.269217724333611,0.0476919903378748,FALSE
+"HCC827","Pearson.est","mTOR inhibitor",0.72123,1.95,0.0127,186,0.21,"deforolimus, PKI.179, PI.103, AZD8055, torin.1, temsirolimus, everolimus, LY3023414, NVP.BEZ235, AZD2014, MLN0128, PP242, sirolimus, GDC.0980, WYE.125132, SB.2343, torin.2",1.89619627904404,0.677780705266081,TRUE
+"HCC827","Pearson.est","NFkB pathway inhibitor",-0.39424,-1.03,0.415,1032,1,"IKK.2.inhibitor.V, curcumin, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.381951903287907,0,FALSE
+"HCC827","Pearson.est","opioid receptor agonist",-0.4026,-1.02,0.397,1222,1,"ADL5859, salvinorin.a",0.401209493236885,0,FALSE
+"HCC827","Pearson.est","p38 MAPK inhibitor",-0.33382,-0.867,0.603,1356,0.876,"skepinone.l",0.219682687859849,0.0574958938319193,FALSE
+"HCC827","Pearson.est","PARP inhibitor",-0.53081,-1.36,0.153,887,0.651,"PJ.34, olaparib, AZD2461, niraparib, AG.14361, talazoparib",0.815308569182401,0.186419011431808,FALSE
+"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.38669,-0.995,0.481,987,0.976,"crenolanib, nintedanib, lenvatinib, imatinib, ponatinib, motesanib, KI.8751, axitinib, vatalanib, telatinib, sunitinib, CP.673451, masitinib",0.317854923626168,0.0105501823333082,FALSE
+"HCC827","Pearson.est","phosphatase inhibitor",-0.38176,-0.983,0.446,1194,0.92,"CID.5458317, menadione, alexidine",0.350665141287858,0.0362121726544447,FALSE
+"HCC827","Pearson.est","phosphodiesterase inhibitor",0.29935,0.771,0.73,130,0.979,"papaverine, enoximone",0.136677139879544,0.00921730819686218,FALSE
+"HCC827","Pearson.est","PI3K inhibitor",0.37876,0.964,0.478,365,1,"PKI.179, PI.103, BGT226, LY3023414, NVP.BEZ235, GDC.0980, SB.2343, voxtalisib, ZSTK.474, PF.04691502, buparlisib, PI3K.IN.2",0.320572103387881,0,FALSE
+"HCC827","Pearson.est","PLK inhibitor",0.35878,0.938,0.498,931,0.932,"HMN.214, BI.2536, NMS.1286937, volasertib, rigosertib, GSK461364, GW.843682X",0.302770657240282,0.0305840876460186,FALSE
+"HCC827","Pearson.est","potassium channel blocker",0.51654,1.36,0.155,505,1,"ML133, ibutilide, oleoylethanolamide, dofetilide, mepivacaine",0.809668301829709,0,FALSE
+"HCC827","Pearson.est","PPAR receptor agonist",-0.29494,-0.754,0.756,1029,0.901,"clofibrate, S26948, fenofibrate",0.121478204498793,0.045275209020937,FALSE
+"HCC827","Pearson.est","progesterone receptor agonist",-0.65779,-1.71,0.0264,1198,0.356,"dienogest, norgestrel, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.57839607313017,0.448550002027125,FALSE
+"HCC827","Pearson.est","proteasome inhibitor",0.37144,0.971,0.478,143,1,"ONX.0914, MG.132",0.320572103387881,0,FALSE
+"HCC827","Pearson.est","protein synthesis inhibitor",0.28833,0.737,0.765,430,0.93,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, azomycin..2.nitroimidazole., chloramphenicol.palmitate",0.116338564846382,0.0315170514460649,FALSE
+"HCC827","Pearson.est","protein tyrosine kinase inhibitor",-0.31362,-0.807,0.67,1329,0.883,"CP.724714, rheochrysidin",0.173925197299174,0.0540392964224314,FALSE
+"HCC827","Pearson.est","RAF inhibitor",0.42764,1.13,0.296,403,1,"SB.590885, vemurafenib, sorafenib, AZ.628, LGX818, dabrafenib, regorafenib",0.528708288941061,0,FALSE
+"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.36107,-0.952,0.479,1368,0.851,"sunitinib",0.319664486585437,0.0700704399154121,FALSE
+"HCC827","Pearson.est","retinoid receptor agonist",0.27733,0.734,0.78,73,0.903,"LE.135",0.10790539730952,0.0443122496864942,FALSE
+"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.33642,-0.868,0.569,1435,0.902,"pentostatin",0.244887733604929,0.0447934624580583,FALSE
+"HCC827","Pearson.est","serotonin receptor agonist",-0.66458,-1.69,0.037,1153,0.324,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",1.431798275933,0.489454989793388,FALSE
+"HCC827","Pearson.est","serotonin receptor antagonist",-0.43997,-1.13,0.308,1152,0.926,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.511449283499556,0.0333890133180656,FALSE
+"HCC827","Pearson.est","sodium channel blocker",0.28044,0.741,0.76,384,0.956,"brivaracetam, ajmaline, cibenzoline, mexiletine, butamben",0.119186407719209,0.0195421077238999,FALSE
+"HCC827","Pearson.est","src inhibitor",-0.45874,-1.17,0.281,1110,1,"bosutinib, PP.1, PP.2, masitinib",0.55129368009492,0,FALSE
+"HCC827","Pearson.est","sterol demethylase inhibitor",0.36396,0.948,0.509,9,1,"chlormidazole",0.293282217663241,0,FALSE
+"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.60063,-1.55,0.0777,1026,0.483,"adaprev, repsox, SB.431542, SB.525334, D.4476",1.10957898119909,0.316052869248488,FALSE
+"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.30166,-0.782,0.691,435,0.901,"ftorafur, doxifluridine, raltitrexed, carmofur, capecitabine, trifluridine",0.160521952625802,0.045275209020937,FALSE
+"HCC827","Pearson.est","topoisomerase inhibitor",0.29492,0.773,0.719,234,1,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate, amsacrine",0.143271109617117,0,FALSE
+"HCC827","Pearson.est","tubulin polymerization inhibitor",0.41592,1.07,0.379,444,0.978,"mebendazole, epothilone.b, BNC105, CYT.997, fenbendazole, oxibendazole, vinorelbine, taltobulin, verubulin, indibulin, dolastatin.10, plinabulin, podophyllotoxin, KX2.391",0.421360790031928,0.00966114521239857,FALSE
+"HCC827","Pearson.est","tyrosine kinase inhibitor",0.26445,0.711,0.797,458,0.877,"AV.412, dasatinib, bafetinib, sorafenib, mubritinib, NVP.TAE226, tivantinib, regorafenib, GTP.14564, tyrphostin.A9, apatinib, PP.121",0.0985416786038876,0.0570004066339595,FALSE
+"HCC827","Pearson.est","VEGFR inhibitor",-0.23412,-0.595,0.903,1088,0.922,"motesanib, MK.2461, AEE788, tivozanib, KI.8751, axitinib, foretinib, lucitanib, vatalanib, telatinib, sunitinib",0.0443122496864942,0.0352690789463706,FALSE
+"HCC827","Pearson.est","vitamin D receptor agonist",0.4443,1.19,0.255,362,1,"ercalcitriol, calcitriol, maxacalcitol",0.593459819566045,0,FALSE
+"CALU3","Pearson.est","EGFR inhibitor",0.41422,1.04,0.395,365,0.924,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, WZ.3146, BMS.690514, XL.647, canertinib, gefitinib, AST.1306, icotinib, BIBX.1382, PD.168393, BIBU.1361, AZD8931, brigatinib, rociletinib, pelitinib, afatinib",0.40340290437354,0.0343280287798933,FALSE
+"CALU3","Pearson.est","Abl kinase inhibitor",-0.35237,-0.914,0.523,1138,0.879,"imatinib, ponatinib, KW.2449, flumatinib",0.281498311132726,0.0560111249262281,FALSE
+"CALU3","Pearson.est","acetylcholine receptor agonist",0.33173,0.848,0.615,324,0.927,"xanomeline, oxiracetam",0.211124884224583,0.0329202658555029,FALSE
+"CALU3","Pearson.est","acetylcholine receptor antagonist",-0.67636,-1.73,0.0336,1083,0.278,"hyoscyamine, darifenacin, methscopolamine, dicycloverine, iododexetimide",1.47366072261016,0.555955204081924,FALSE
+"CALU3","Pearson.est","adenosine receptor antagonist",-0.32816,-0.869,0.55,1433,0.883,"istradefylline",0.259637310505756,0.0540392964224314,FALSE
+"CALU3","Pearson.est","adrenergic receptor agonist",-0.41116,-1.08,0.357,1101,0.729,"A61603, oxymetazoline, terbutaline, xylazine, norepinephrine, isoetharine",0.447331783887807,0.137272471682025,FALSE
+"CALU3","Pearson.est","adrenergic receptor antagonist",0.26246,0.684,0.844,217,0.967,"practolol, propranolol, idazoxan, vincamine",0.073657553374345,0.0145735259169983,FALSE
+"CALU3","Pearson.est","AKT inhibitor",0.49628,1.28,0.201,412,0.905,"MK.2206, ONC201, triciribine, AT7867, GSK2110183, palomid.529",0.696803942579511,0.0433514207947967,FALSE
+"CALU3","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41023,-1.1,0.314,1390,0.796,"CEP.37440, DMH1",0.503070351926785,0.0990869322623309,FALSE
+"CALU3","Pearson.est","androgen receptor antagonist",-0.76229,-2,0.00218,1242,0.105,"flutamide, enzalutamide, cyproterone.acetate",2.6615435063954,0.978810700930062,TRUE
+"CALU3","Pearson.est","antioxidant",-0.57359,-1.48,0.13,909,0.5,"rutin, mesna, benfotiamine, trolox",0.886056647693163,0.301029995663981,FALSE
+"CALU3","Pearson.est","AP inhibitor",0.62025,1.58,0.0674,94,0.721,"birinapant, GDC.0152",1.17134010346468,0.142064735280571,FALSE
+"CALU3","Pearson.est","ATPase inhibitor",0.55547,1.43,0.109,309,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.962573502059376,0,FALSE
+"CALU3","Pearson.est","Aurora kinase inhibitor",0.28721,0.739,0.749,469,0.918,"barasertib.HQPA, MK.8745, MK.5108, barasertib, ENMD.2076, alisertib, PF.03814735, danusertib, ZM.447439, CCT137690",0.125518182300534,0.0371573187987575,FALSE
+"CALU3","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.44167,-1.16,0.279,1378,0.707,"azalomycin.b, dirithromycin",0.554395796726402,0.150580586203101,FALSE
+"CALU3","Pearson.est","bacterial DNA gyrase inhibitor",0.40297,1.02,0.395,88,0.818,"lomefloxacin, finafloxacin",0.40340290437354,0.087246696328677,FALSE
+"CALU3","Pearson.est","BCL inhibitor",-0.36302,-0.932,0.513,1415,0.908,"gossypol, ABT.737",0.289882634888184,0.0419141514789149,FALSE
+"CALU3","Pearson.est","Bcr.Abl kinase inhibitor",-0.28058,-0.716,0.777,1138,0.939,"imatinib, ponatinib, flumatinib",0.109578981199086,0.0273344077338891,FALSE
+"CALU3","Pearson.est","benzodiazepine receptor agonist",0.43168,1.08,0.356,40,0.95,"bentazepam, gamma.aminobutyric.acid, ivermectin",0.448550002027125,0.0222763947111523,FALSE
+"CALU3","Pearson.est","bromodomain inhibitor",-0.4561,-1.21,0.224,1045,0.736,"bromosporine, I.BET151, PFI.1",0.649751981665837,0.133122185662501,FALSE
+"CALU3","Pearson.est","calcium channel blocker",-0.41109,-1.08,0.338,1258,0.729,"efonidipine.monoethanolate, SR.33805, mibefradil",0.471083299722345,0.137272471682025,FALSE
+"CALU3","Pearson.est","CC chemokine receptor antagonist",-0.27273,-0.714,0.805,393,0.919,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, PF.04136309, navarixin",0.0942041196321315,0.0366844886138887,FALSE
+"CALU3","Pearson.est","CDK inhibitor",-0.36872,-0.958,0.487,1077,0.886,"indirubin, R547, abemaciclib, AZD5438, ribociclib, BMS.265246, TG.02, JNJ.7706621",0.312471038785366,0.0525662781129492,FALSE
+"CALU3","Pearson.est","CHK inhibitor",-0.54134,-1.46,0.0975,1214,0.487,"AZD7762, SCH.900776, SB.218078",1.01099538430146,0.312471038785366,FALSE
+"CALU3","Pearson.est","cyclooxygenase inhibitor",-0.31535,-0.817,0.639,1062,0.897,"phenazone, indoprofen, AM.404, curcumin, tryptanthrin, acetylsalicylsalicylic.acid, FR.122047, naproxen, piroxicam",0.1944991418416,0.0472075569559079,FALSE
+"CALU3","Pearson.est","cytochrome P450 inhibitor",0.52347,1.32,0.164,366,0.901,"PF.4981517, morin, eplerenone",0.785156151952302,0.045275209020937,FALSE
+"CALU3","Pearson.est","DNA alkylating agent",-0.29814,-0.791,0.68,949,0.918,"melphalan, mitomycin.c, estramustine, satraplatin, TH.302, cyclophosphamide, streptozotocin, carmustine, temozolomide",0.167491087293764,0.0371573187987575,FALSE
+"CALU3","Pearson.est","DNA inhibitor",-0.20073,-0.526,0.964,1360,0.968,"nithiamide, pibenzimol",0.0159229660971692,0.0141246426916063,FALSE
+"CALU3","Pearson.est","DNA methyltransferase inhibitor",0.48752,1.26,0.227,745,0.775,"azacitidine, SGI.1027, fdcyd, RG108, disulfiram, decitabine",0.643974142806877,0.11069829749369,FALSE
+"CALU3","Pearson.est","DNA polymerase inhibitor",0.41697,1.07,0.361,138,0.91,"cephalomannine, foscarnet, cidofovir",0.442492798094342,0.0409586076789064,FALSE
+"CALU3","Pearson.est","DNA synthesis inhibitor",-0.27801,-0.727,0.807,1313,0.947,"altretamine, enocitabine",0.0931264652779296,0.0236500209967266,FALSE
+"CALU3","Pearson.est","dopamine receptor antagonist",-0.2889,-0.76,0.764,1175,0.918,"mesoridazine, ziprasidone, paliperidone, lurasidone, amisulpride",0.11690664142431,0.0371573187987575,FALSE
+"CALU3","Pearson.est","estrogen receptor agonist",0.22777,0.578,0.95,467,0.962,"PPT, equol, levonorgestrel, estradiol",0.0222763947111523,0.0168249279621871,FALSE
+"CALU3","Pearson.est","estrogen receptor antagonist",-0.69967,-1.85,0.0161,1386,0.225,"danazol, fulvestrant, tamoxifen",1.79317412396815,0.647817481888638,TRUE
+"CALU3","Pearson.est","FGFR inhibitor",-0.34937,-0.91,0.562,1174,0.857,"nintedanib, MK.2461, lucitanib",0.250263684430939,0.0670191780768018,FALSE
+"CALU3","Pearson.est","FLT3 inhibitor",-0.38582,-1,0.442,1135,0.864,"quizartinib, ponatinib, pacritinib, KW.2449, TG.02, lestaurtinib, sunitinib",0.354577730650908,0.0634862575211067,FALSE
+"CALU3","Pearson.est","glucocorticoid receptor agonist",-0.22533,-0.596,0.913,1011,1,"halobetasol.propionate, prednisolone.acetate, rimexolone, flumethasone, fluticasone.propionate, fluocinolone.acetonide, hydrocortisone, beclomethasone.dipropionate, piretanide, dexamethasone.acetate, flumethasone.pivalate",0.039529222465701,0,FALSE
+"CALU3","Pearson.est","glutamate receptor antagonist",0.33437,0.842,0.609,188,0.901,"ACDPP, tiletamine, kynurenic.acid",0.215382707367125,0.045275209020937,FALSE
+"CALU3","Pearson.est","glycogen synthase kinase inhibitor",0.30558,0.781,0.697,65,0.911,"CHIR.99021",0.156767221901991,0.0404816230270017,FALSE
+"CALU3","Pearson.est","growth factor receptor inhibitor",-0.58993,-1.56,0.0774,1232,0.411,"GSK1838705A, GW.441756, lestaurtinib",1.11125903931711,0.386158178123931,FALSE
+"CALU3","Pearson.est","HCV inhibitor",0.49607,1.26,0.21,101,0.775,"daclatasvir",0.677780705266081,0.11069829749369,FALSE
+"CALU3","Pearson.est","HDAC inhibitor",0.42784,1.1,0.323,203,0.969,"nexturastat.a, chidamide, panobinostat, NSC.3852, belinostat, scriptaid, ACY.1215, SB.939",0.490797477668897,0.0136762229492347,FALSE
+"CALU3","Pearson.est","histamine receptor antagonist",-0.21192,-0.547,0.947,1283,0.978,"ebastine, tiotidine, BF2.649",0.0236500209967266,0.00966114521239857,FALSE
+"CALU3","Pearson.est","HMGCR inhibitor",0.55904,1.4,0.133,395,0.945,"atorvastatin, simvastatin, pitavastatin",0.876148359032914,0.0245681914907371,FALSE
+"CALU3","Pearson.est","HSP inhibitor",0.40428,1.02,0.415,377,0.818,"BIIB021, PU.H71, NMS.E973, SNX.2112, ganetespib, SNX.5422, KW.2478, NVP.AUY922",0.381951903287907,0.087246696328677,FALSE
+"CALU3","Pearson.est","JAK inhibitor",-0.26797,-0.697,0.838,1137,0.92,"AZD1480, filgotinib, pacritinib, TG.02, lestaurtinib",0.0767559813697235,0.0362121726544447,FALSE
+"CALU3","Pearson.est","KIT inhibitor",-0.41327,-1.08,0.357,1291,0.729,"KI.8751, vatalanib, telatinib, sunitinib, masitinib",0.447331783887807,0.137272471682025,FALSE
+"CALU3","Pearson.est","MDM inhibitor",0.45416,1.18,0.289,496,0.827,"serdemetan, idasanutlin, AMG.232",0.539102157243452,0.0824944904474534,FALSE
+"CALU3","Pearson.est","MEK inhibitor",-0.32963,-0.88,0.569,1153,0.891,"refametinib, cobimetinib, MEK162, nobiletin, BIX.02188, arctigenin",0.244887733604929,0.0501222959631252,FALSE
+"CALU3","Pearson.est","MET inhibitor",-0.86406,-2.27,0,1370,0.0086,"PHA.665752, INC.280, AMG458, NVP.BVU972",Inf,2.06550154875643,TRUE
+"CALU3","Pearson.est","microtubule inhibitor",0.33939,0.857,0.614,136,0.948,"estramustine.phosphate, triclabendazole",0.211831628858832,0.0231916626619338,FALSE
+"CALU3","Pearson.est","mTOR inhibitor",0.63925,1.63,0.0374,312,1,"PI.103, deforolimus, torin.1, AZD8055, PKI.179, PP242, LY3023414, NVP.BEZ235, everolimus, MLN0128, SB.2343, sirolimus, AZD2014, temsirolimus, WYE.125132, PF.04691502, GDC.0980, voxtalisib",1.42712839779952,0,FALSE
+"CALU3","Pearson.est","NFkB pathway inhibitor",-0.4515,-1.16,0.289,1398,0.707,"parthenolide, Ro.106.9920, betulinic.acid",0.539102157243452,0.150580586203101,FALSE
+"CALU3","Pearson.est","opioid receptor agonist",-0.37027,-0.974,0.448,1250,0.884,"ADL5859, salvinorin.a",0.348721986001856,0.0535477349869269,FALSE
+"CALU3","Pearson.est","p38 MAPK inhibitor",-0.21069,-0.557,0.954,1121,0.995,"TAK.715, skepinone.l",0.0204516252959049,0.00217691925427455,FALSE
+"CALU3","Pearson.est","PARP inhibitor",-0.61088,-1.61,0.0526,963,0.373,"niraparib, AG.14361, PJ.34, olaparib, AZD2461, talazoparib",1.27901425584626,0.428291168191312,FALSE
+"CALU3","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.46091,-1.24,0.232,1138,0.778,"imatinib, ponatinib, nintedanib, axitinib, KI.8751, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.6345120151091,0.109020403010311,FALSE
+"CALU3","Pearson.est","phosphatase inhibitor",-0.29115,-0.776,0.722,1022,0.915,"BVT.948, CID.5458317, menadione, alexidine",0.141462802430361,0.0385789059335517,FALSE
+"CALU3","Pearson.est","phosphodiesterase inhibitor",0.29692,0.746,0.75,266,0.939,"papaverine, cilostamide, enoximone",0.1249387366083,0.0273344077338891,FALSE
+"CALU3","Pearson.est","PI3K inhibitor",0.33304,0.857,0.602,312,0.948,"PI.103, PKI.179, LY3023414, BGT226, NVP.BEZ235, SB.2343, YM.201636, PF.04691502, GDC.0980, voxtalisib",0.220403508742175,0.0231916626619338,FALSE
+"CALU3","Pearson.est","PLK inhibitor",0.30812,0.797,0.686,1004,0.916,"HMN.214, BI.2536, NMS.1286937, volasertib, rigosertib, GSK461364, GW.843682X",0.163675884293248,0.0381045263321496,FALSE
+"CALU3","Pearson.est","potassium channel blocker",0.62024,1.61,0.0582,272,0.931,"ibutilide, ML133, oleoylethanolamide",1.23507701535011,0.0310503190186574,FALSE
+"CALU3","Pearson.est","PPAR receptor agonist",0.3196,0.83,0.644,284,0.89,"pterostilbene, oleoylethanolamide, ciprofibrate",0.191114132640188,0.0506099933550872,FALSE
+"CALU3","Pearson.est","progesterone receptor agonist",-0.46163,-1.21,0.219,1219,0.736,"nomegestrol.acetate, melengestrol.acetate, norethindrone.acetate, danazol",0.659555885159882,0.133122185662501,FALSE
+"CALU3","Pearson.est","proteasome inhibitor",0.36266,0.923,0.509,162,0.898,"ONX.0914, MG.132",0.293282217663241,0.0467236633326956,FALSE
+"CALU3","Pearson.est","protein synthesis inhibitor",0.35429,0.929,0.536,355,0.927,"clofoctol, cycloheximide, azomycin..2.nitroimidazole., chloramphenicol.palmitate, thiostrepton, brefeldin.a",0.27083521030723,0.0329202658555029,FALSE
+"CALU3","Pearson.est","protein tyrosine kinase inhibitor",-0.34836,-0.916,0.551,1297,0.907,"BMS.599626, CP.724714, rheochrysidin",0.258848401148215,0.0423927129399047,FALSE
+"CALU3","Pearson.est","RAF inhibitor",0.23752,0.589,0.913,202,0.981,"SB.590885, vemurafenib",0.039529222465701,0.0083309926200515,FALSE
+"CALU3","Pearson.est","RET tyrosine kinase inhibitor",-0.46731,-1.25,0.198,1420,0.816,"sunitinib",0.703334809738469,0.0883098412461389,FALSE
+"CALU3","Pearson.est","retinoid receptor agonist",0.26606,0.679,0.827,86,0.943,"LE.135",0.0824944904474534,0.0254883072626717,FALSE
+"CALU3","Pearson.est","ribonucleotide reductase inhibitor",-0.32211,-0.835,0.636,1240,0.92,"clofarabine, pentostatin",0.196542884351586,0.0362121726544447,FALSE
+"CALU3","Pearson.est","serotonin receptor agonist",-0.68738,-1.83,0.0218,1181,0.188,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",1.6615435063954,0.72584215073632,TRUE
+"CALU3","Pearson.est","serotonin receptor antagonist",-0.45122,-1.2,0.23,1186,0.709,"ziprasidone, paliperidone, RS.16566, lurasidone, aripiprazole",0.638272163982407,0.149353764816933,FALSE
+"CALU3","Pearson.est","sodium channel blocker",0.21914,0.573,0.934,439,0.94,"brivaracetam, cibenzoline, ajmaline, butamben",0.0296531237699066,0.0268721464003014,FALSE
+"CALU3","Pearson.est","src inhibitor",-0.54216,-1.42,0.121,1209,0.511,"PP.1, TG.100572, PP.2, masitinib",0.91721462968355,0.291579099865287,FALSE
+"CALU3","Pearson.est","sterol demethylase inhibitor",0.40576,1.03,0.437,171,0.892,"chlormidazole, terconazole",0.359518563029578,0.0496351456238769,FALSE
+"CALU3","Pearson.est","TGF beta receptor inhibitor",-0.61649,-1.69,0.0599,965,0.291,"SB.525334, adaprev, repsox, SB.431542, D.4476",1.22257317761069,0.536107011014093,FALSE
+"CALU3","Pearson.est","thymidylate synthase inhibitor",0.3689,0.931,0.521,174,0.968,"ftorafur",0.283162276700476,0.0141246426916063,FALSE
+"CALU3","Pearson.est","topoisomerase inhibitor",-0.22671,-0.591,0.95,1140,0.993,"TAS.103, SN.38, fleroxacin, dexrazoxane, irinotecan, beta.lapachone, etoposide.phosphate",0.0222763947111523,0.00305075150461883,FALSE
+"CALU3","Pearson.est","tubulin polymerization inhibitor",0.45534,1.18,0.289,267,0.827,"BNC105, mebendazole, epothilone.b, oxibendazole, CYT.997, vinorelbine, verubulin, taltobulin, indibulin, fenbendazole, dolastatin.10",0.539102157243452,0.0824944904474534,FALSE
+"CALU3","Pearson.est","tyrosine kinase inhibitor",0.23813,0.604,0.894,450,0.997,"AV.412, NVP.TAE226, dasatinib, GTP.14564, bafetinib, mubritinib, aminopurvalanol.a, PP.121, apatinib, sorafenib, tyrphostin.A9",0.0486624812040823,0.00130484168834428,FALSE
+"CALU3","Pearson.est","VEGFR inhibitor",-0.32216,-0.828,0.668,1174,0.905,"nintedanib, MK.2461, axitinib, tivozanib, KI.8751, TG.100572, lucitanib, vatalanib, telatinib, foretinib, sunitinib",0.175223537524454,0.0433514207947967,FALSE
+"CALU3","Pearson.est","vitamin D receptor agonist",0.53112,1.37,0.156,392,0.883,"maxacalcitol, ercalcitriol, calcitriol",0.806875401645538,0.0540392964224314,FALSE
+"H2009","Pearson.est","EGFR inhibitor",0.43488,1.12,0.331,228,0.838,"CUDC.101, tyrphostin.AG.1478, ARRY.334543, BMS.690514, erlotinib, WZ.3146, XL.647, canertinib, BIBX.1382, gefitinib, brigatinib, AST.1306, PD.168393, BIBU.1361, icotinib",0.480172006224281,0.0767559813697235,FALSE
+"H2009","Pearson.est","Abl kinase inhibitor",0.25271,0.658,0.871,240,0.909,"dasatinib, bafetinib, metatinib",0.0599818449923368,0.0414361167780325,FALSE
+"H2009","Pearson.est","acetylcholine receptor agonist",0.24314,0.629,0.863,372,0.916,"xanomeline, oxiracetam",0.0639892042847904,0.0381045263321496,FALSE
+"H2009","Pearson.est","acetylcholine receptor antagonist",-0.69679,-1.85,0.0127,1342,0.209,"iododexetimide, dicycloverine, methscopolamine",1.89619627904404,0.679853713888946,TRUE
+"H2009","Pearson.est","adenosine receptor antagonist",-0.37679,-0.997,0.425,1431,1,"istradefylline",0.371611069949688,0,FALSE
+"H2009","Pearson.est","adrenergic receptor agonist",-0.4167,-1.09,0.337,995,0.98,"midodrine, A61603, clenbuterol, terbutaline, xylazine, oxymetazoline, ritodrine, methyldopa, norepinephrine, isoetharine",0.472370099128661,0.00877392430750515,FALSE
+"H2009","Pearson.est","adrenergic receptor antagonist",0.37567,0.948,0.508,188,0.767,"practolol, propranolol, idazoxan, vincamine",0.294136287716081,0.115204636051019,FALSE
+"H2009","Pearson.est","AKT inhibitor",0.40784,1.06,0.382,470,0.769,"triciribine, MK.2206, ONC201, AT7867, palomid.529, GSK2110183",0.417936637088291,0.114073660198569,FALSE
+"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.37674,-0.982,0.451,1381,0.949,"DMH1, CEP.37440",0.345823458122039,0.0227337875727074,FALSE
+"H2009","Pearson.est","androgen receptor antagonist",-0.65152,-1.72,0.0448,1250,0.293,"flutamide, enzalutamide, cyproterone.acetate",1.34872198600186,0.533132379645891,FALSE
+"H2009","Pearson.est","antioxidant",-0.62724,-1.64,0.0484,1190,0.28,"benfotiamine, trolox",1.31515463835559,0.552841968657781,FALSE
+"H2009","Pearson.est","AP inhibitor",0.65559,1.69,0.0304,82,1,"birinapant, GDC.0152",1.51712641639125,0,FALSE
+"H2009","Pearson.est","ATPase inhibitor",0.47335,1.2,0.263,268,1,"k.strophanthidin, oligomycin.a, evodiamine, blebbistatin...., ouabain",0.580044251510242,0,FALSE
+"H2009","Pearson.est","Aurora kinase inhibitor",0.37072,0.954,0.476,491,0.788,"MK.5108, barasertib.HQPA, barasertib, MK.8745, ENMD.2076, alisertib, PF.03814735, ZM.447439, MLN.8054, CCT137690, danusertib, SNS.314",0.322393047279507,0.103473782510445,FALSE
+"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40125,-1.05,0.383,1341,0.971,"azalomycin.b, dirithromycin",0.416801226031377,0.0127807700919951,FALSE
+"H2009","Pearson.est","bacterial DNA gyrase inhibitor",0.46438,1.22,0.231,176,1,"lomefloxacin, finafloxacin, novobiocin",0.636388020107856,0,FALSE
+"H2009","Pearson.est","BCL inhibitor",0.3556,0.899,0.566,290,0.799,"oridonin, obatoclax, TW.37, HA14.1, venetoclax",0.247183568811729,0.0974532206860086,FALSE
+"H2009","Pearson.est","Bcr.Abl kinase inhibitor",0.31124,0.798,0.692,240,0.8,"dasatinib, bafetinib, metatinib",0.159893905543242,0.0969100130080564,FALSE
+"H2009","Pearson.est","benzodiazepine receptor agonist",0.40329,1.06,0.395,150,0.769,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.40340290437354,0.114073660198569,FALSE
+"H2009","Pearson.est","bromodomain inhibitor",-0.52386,-1.37,0.135,965,0.616,"JQ1...., bromosporine, I.BET151, PFI.1",0.869666231504994,0.210419287835575,FALSE
+"H2009","Pearson.est","calcium channel blocker",-0.35542,-0.944,0.508,1232,0.881,"SR.33805, efonidipine.monoethanolate, mibefradil",0.294136287716081,0.0550240915879521,FALSE
+"H2009","Pearson.est","CC chemokine receptor antagonist",-0.27203,-0.703,0.796,392,0.957,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.0990869322623309,0.0190880622231565,FALSE
+"H2009","Pearson.est","CDK inhibitor",-0.27768,-0.706,0.808,1041,1,"indirubin, R547, AZD5438, abemaciclib, BMS.265246, JNJ.7706621, ribociclib, TG.02",0.0925886392254138,0,FALSE
+"H2009","Pearson.est","CHK inhibitor",-0.50283,-1.32,0.193,1122,0.66,"SCH.900776, AZD7762, SB.218078",0.714442690992226,0.180456064458131,FALSE
+"H2009","Pearson.est","cyclooxygenase inhibitor",-0.3588,-0.941,0.501,1236,0.855,"AM.404, acetylsalicylsalicylic.acid, piroxicam, FR.122047, tryptanthrin, naproxen",0.300162274132754,0.0680338852718274,FALSE
+"H2009","Pearson.est","cytochrome P450 inhibitor",0.59583,1.53,0.0635,221,0.946,"PF.4981517, morin, eplerenone",1.19722627470802,0.0241088635982073,FALSE
+"H2009","Pearson.est","DNA alkylating agent",-0.38619,-1.03,0.395,1001,0.969,"TH.302, estramustine, mitomycin.c, cyclophosphamide, streptozotocin, melphalan, satraplatin, carmustine, temozolomide",0.40340290437354,0.0136762229492347,FALSE
+"H2009","Pearson.est","DNA inhibitor",-0.23036,-0.61,0.915,1118,0.91,"melphalan, carmustine, busulfan, nithiamide, pibenzimol",0.0385789059335517,0.0409586076789064,FALSE
+"H2009","Pearson.est","DNA methyltransferase inhibitor",0.51456,1.33,0.175,706,1,"SGI.1027, decitabine, azacitidine, fdcyd, RG108, disulfiram",0.756961951313706,0,FALSE
+"H2009","Pearson.est","DNA polymerase inhibitor",0.39041,0.997,0.433,124,0.817,"foscarnet, cephalomannine, cidofovir",0.363512103646635,0.0877779434675845,FALSE
+"H2009","Pearson.est","DNA synthesis inhibitor",-0.25985,-0.69,0.846,1298,0.927,"altretamine, enocitabine",0.0726296369609765,0.0329202658555029,FALSE
+"H2009","Pearson.est","dopamine receptor antagonist",-0.38065,-0.995,0.419,1185,0.962,"mesoridazine, remoxipride, ziprasidone, paliperidone, amisulpride, lurasidone",0.377785977033705,0.0168249279621871,FALSE
+"H2009","Pearson.est","estrogen receptor agonist",-0.2893,-0.758,0.761,1395,1,"erteberel",0.118615343229427,0,FALSE
+"H2009","Pearson.est","estrogen receptor antagonist",-0.81465,-2.11,0,1297,0.0655,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.18375870000822,TRUE
+"H2009","Pearson.est","FGFR inhibitor",-0.35181,-0.916,0.532,1024,0.845,"nintedanib, lenvatinib, MK.2461, lucitanib",0.274088367704952,0.0731432910503077,FALSE
+"H2009","Pearson.est","FLT3 inhibitor",-0.36909,-0.971,0.448,1103,0.896,"ponatinib, TG.101348, quizartinib, KW.2449, pacritinib, TG.02, lestaurtinib, sunitinib",0.348721986001856,0.0476919903378748,FALSE
+"H2009","Pearson.est","glucocorticoid receptor agonist",-0.29471,-0.767,0.723,858,1,"clobetasol.propionate, triamcinolone.acetonide, fluorometholone, prednisolone, halcinonide, triamcinolone, fludroxycortide, halobetasol.propionate, rimexolone, flumethasone, beclomethasone.dipropionate, hydrocortisone, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate",0.140861702705469,0,FALSE
+"H2009","Pearson.est","glutamate receptor antagonist",0.35455,0.916,0.532,159,0.798,"ACDPP, tiletamine, kynurenic.acid",0.274088367704952,0.0979971086492706,FALSE
+"H2009","Pearson.est","glycogen synthase kinase inhibitor",0.38542,1,0.429,35,0.853,"CHIR.99021",0.367542707815276,0.069050968832477,FALSE
+"H2009","Pearson.est","growth factor receptor inhibitor",-0.63283,-1.71,0.0238,1256,0.258,"GSK1838705A, GW.441756, lestaurtinib",1.62342304294349,0.58838029403677,FALSE
+"H2009","Pearson.est","HCV inhibitor",0.45544,1.15,0.282,97,0.899,"daclatasvir",0.549750891680639,0.0462403082667712,FALSE
+"H2009","Pearson.est","HDAC inhibitor",0.43208,1.1,0.326,440,0.828,"chidamide, nexturastat.a, panobinostat, NSC.3852, belinostat, ACY.1215, scriptaid, SB.939, entinostat, romidepsin, resminostat, givinostat, mocetinostat, M.344",0.486782399932061,0.0819696632151199,FALSE
+"H2009","Pearson.est","histamine receptor antagonist",-0.26143,-0.67,0.849,1037,0.931,"ICI.162846, cyproheptadine, ranitidine, terfenadine, ebastine, tiotidine, epinastine, BF2.649",0.0710923097560473,0.0310503190186574,FALSE
+"H2009","Pearson.est","HMGCR inhibitor",0.44893,1.18,0.279,388,0.901,"atorvastatin, simvastatin, pitavastatin",0.554395796726402,0.045275209020937,FALSE
+"H2009","Pearson.est","HSP inhibitor",0.43233,1.13,0.306,319,0.878,"BIIB021, NMS.E973, PU.H71, SNX.2112, ganetespib, NVP.AUY922, SNX.5422",0.51427857351842,0.0565054840938974,FALSE
+"H2009","Pearson.est","JAK inhibitor",-0.38191,-0.981,0.443,1132,0.911,"TG.101348, CEP.33779, filgotinib, pacritinib, AZD1480, TG.02, lestaurtinib",0.35359627377693,0.0404816230270017,FALSE
+"H2009","Pearson.est","KIT inhibitor",-0.34271,-0.889,0.578,1116,0.839,"imatinib, lenvatinib, KI.8751, vatalanib, telatinib, masitinib, sunitinib",0.238072161579471,0.0762380391712997,FALSE
+"H2009","Pearson.est","MDM inhibitor",0.49178,1.28,0.196,330,1,"serdemetan, idasanutlin, AMG.232",0.707743928643524,0,FALSE
+"H2009","Pearson.est","MEK inhibitor",-0.2607,-0.668,0.834,1195,0.912,"MEK162, nobiletin, BIX.02188, arctigenin",0.0788339493622613,0.0400051616715838,FALSE
+"H2009","Pearson.est","MET inhibitor",-0.7772,-2.01,0.00208,1252,0.0877,"PHA.665752, INC.280, NVP.BVU972, AMG458",2.68193666503724,1.05700040663396,TRUE
+"H2009","Pearson.est","microtubule inhibitor",0.41839,1.08,0.369,410,0.822,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel",0.43297363384094,0.0851281824599496,FALSE
+"H2009","Pearson.est","mTOR inhibitor",0.65926,1.68,0.0328,452,0.65,"deforolimus, PI.103, torin.1, AZD8055, PKI.179, PP242, everolimus, NVP.BEZ235, LY3023414, MLN0128, temsirolimus, SB.2343, AZD2014, sirolimus, GDC.0980, WYE.125132, torin.2, PF.04691502, WAY.600, voxtalisib, ku.0063794, palomid.529, PF.05212384",1.48412615628832,0.187086643357144,FALSE
+"H2009","Pearson.est","NFkB pathway inhibitor",-0.36674,-0.964,0.478,1098,0.874,"IKK.2.inhibitor.V, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.320572103387881,0.058488567365597,FALSE
+"H2009","Pearson.est","opioid receptor agonist",-0.44068,-1.15,0.286,1259,0.882,"ADL5859, salvinorin.a",0.543633966870957,0.0545314148681803,FALSE
+"H2009","Pearson.est","p38 MAPK inhibitor",-0.26527,-0.69,0.808,1112,0.927,"TAK.715, skepinone.l",0.0925886392254138,0.0329202658555029,FALSE
+"H2009","Pearson.est","PARP inhibitor",-0.59762,-1.57,0.0701,958,0.348,"PJ.34, AZD2461, niraparib, olaparib, AG.14361, talazoparib",1.15428198203334,0.458420756053419,FALSE
+"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.40835,-1.06,0.361,1103,0.999,"ponatinib, imatinib, axitinib, lenvatinib, KI.8751, vatalanib, telatinib, CP.673451, masitinib, sunitinib",0.442492798094342,0.000434511774017692,FALSE
+"H2009","Pearson.est","phosphatase inhibitor",-0.28515,-0.748,0.762,1183,0.989,"CID.5458317, menadione, alexidine",0.1180450286604,0.0048037084028206,FALSE
+"H2009","Pearson.est","phosphodiesterase inhibitor",-0.25122,-0.656,0.881,1219,0.905,"trequinsin, GSK256066, avanafil",0.0550240915879521,0.0433514207947967,FALSE
+"H2009","Pearson.est","PI3K inhibitor",0.38183,0.98,0.447,485,0.775,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, SB.2343, GDC.0980, ZSTK.474, PF.04691502, voxtalisib, buparlisib, YM.201636, PF.05212384, PI.828, CUDC.907, PI3K.IN.2",0.349692476868064,0.11069829749369,FALSE
+"H2009","Pearson.est","PLK inhibitor",0.30743,0.807,0.682,1005,0.813,"HMN.214, BI.2536, NMS.1286937, GSK461364, volasertib, rigosertib, GW.843682X",0.166215625343521,0.0899094544059319,FALSE
+"H2009","Pearson.est","potassium channel blocker",0.52059,1.33,0.184,534,1,"ibutilide, ML133, oleoylethanolamide, mepivacaine, dofetilide",0.735182176990464,0,FALSE
+"H2009","Pearson.est","PPAR receptor agonist",-0.28328,-0.74,0.788,1377,0.975,"fenofibrate",0.103473782510445,0.0109953843014632,FALSE
+"H2009","Pearson.est","progesterone receptor agonist",-0.54586,-1.42,0.116,1215,0.569,"dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",0.935542010773082,0.244887733604929,FALSE
+"H2009","Pearson.est","proteasome inhibitor",0.38328,0.992,0.445,193,0.788,"ONX.0914, MG.132",0.351639989019068,0.103473782510445,FALSE
+"H2009","Pearson.est","protein synthesis inhibitor",0.27134,0.69,0.833,512,0.897,"clofoctol, cycloheximide, thiostrepton, brefeldin.a, methacycline, chloramphenicol.palmitate, azomycin..2.nitroimidazole., puromycin",0.0793549985932124,0.0472075569559079,FALSE
+"H2009","Pearson.est","protein tyrosine kinase inhibitor",-0.29371,-0.766,0.728,1206,1,"BMS.599626, CP.724714, rheochrysidin",0.137868620686963,0,FALSE
+"H2009","Pearson.est","RAF inhibitor",0.33956,0.887,0.598,408,0.79,"SB.590885, vemurafenib, LGX818, sorafenib, AZ.628",0.223298816011589,0.102372908709559,FALSE
+"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.5013,-1.3,0.181,1417,0.651,"sunitinib",0.742321425130815,0.186419011431808,FALSE
+"H2009","Pearson.est","retinoid receptor agonist",0.33301,0.877,0.591,83,0.779,"LE.135",0.228412519118745,0.108462542327436,FALSE
+"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.34258,-0.9,0.559,1440,0.847,"pentostatin",0.252588192113577,0.0721165896692931,FALSE
+"H2009","Pearson.est","serotonin receptor agonist",-0.7053,-1.83,0.0117,1354,0.182,"zolmitriptan, ipsapirone, aripiprazole",1.93181413825384,0.739928612014925,TRUE
+"H2009","Pearson.est","serotonin receptor antagonist",-0.48555,-1.27,0.203,1213,0.66,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.692503962086787,0.180456064458131,FALSE
+"H2009","Pearson.est","sodium channel blocker",0.31846,0.842,0.629,457,0.785,"brivaracetam, ajmaline, cibenzoline, butamben, mexiletine, mepivacaine",0.201349354554731,0.105130343254747,FALSE
+"H2009","Pearson.est","src inhibitor",-0.35354,-0.934,0.487,1081,0.839,"TG.100572, PP.1, PP.2, masitinib",0.312471038785366,0.0762380391712997,FALSE
+"H2009","Pearson.est","sterol demethylase inhibitor",0.33175,0.851,0.642,25,0.796,"chlormidazole",0.192464971931147,0.0990869322623309,FALSE
+"H2009","Pearson.est","TGF beta receptor inhibitor",-0.63306,-1.66,0.0341,1016,0.291,"repsox, SB.431542, SB.525334, D.4476",1.4672456210075,0.536107011014093,FALSE
+"H2009","Pearson.est","thymidylate synthase inhibitor",-0.26015,-0.704,0.815,1216,0.981,"trifluridine",0.0888423912600234,0.0083309926200515,FALSE
+"H2009","Pearson.est","topoisomerase inhibitor",0.2849,0.752,0.741,346,0.84,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate, amsacrine, epirubicin, voreloxin",0.130181792020672,0.0757207139381184,FALSE
+"H2009","Pearson.est","tubulin polymerization inhibitor",0.4549,1.18,0.268,428,0.901,"epothilone.b, mebendazole, BNC105, oxibendazole, CYT.997, vinorelbine, verubulin, fenbendazole, indibulin, taltobulin, dolastatin.10, plinabulin, podophyllotoxin, KX2.391",0.571865205971211,0.045275209020937,FALSE
+"H2009","Pearson.est","tyrosine kinase inhibitor",0.23289,0.606,0.908,447,0.912,"dasatinib, AV.412, NVP.TAE226, mubritinib, bafetinib, GTP.14564, sorafenib, vandetanib, PP.121, tyrphostin.A9",0.0419141514789149,0.0400051616715838,FALSE
+"H2009","Pearson.est","VEGFR inhibitor",-0.24485,-0.63,0.881,1152,0.912,"axitinib, lenvatinib, MK.2461, KI.8751, tivozanib, vatalanib, lucitanib, telatinib, foretinib, sunitinib",0.0550240915879521,0.0400051616715838,FALSE
+"H2009","Pearson.est","vitamin D receptor agonist",0.52393,1.35,0.149,354,1,"ercalcitriol, calcitriol, maxacalcitol",0.826813731587726,0,FALSE
+"HCC4006","Pearson.est","EGFR inhibitor",0.37425,0.98,0.472,388,1,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, BMS.690514, erlotinib, WZ.3146, XL.647, canertinib, gefitinib, brigatinib, AST.1306, PD.168393, BIBU.1361, icotinib, BIBX.1382, pelitinib, afatinib, AZD8931, lapatinib, rociletinib",0.326058001365912,0,FALSE
+"HCC4006","Pearson.est","Abl kinase inhibitor",0.26596,0.676,0.836,228,0.922,"dasatinib, metatinib, bafetinib",0.0777937225609836,0.0352690789463706,FALSE
+"HCC4006","Pearson.est","acetylcholine receptor agonist",0.21941,0.568,0.95,133,0.972,"xanomeline",0.0222763947111523,0.0123337350737254,FALSE
+"HCC4006","Pearson.est","acetylcholine receptor antagonist",-0.71373,-1.85,0.0114,1310,0.211,"dicycloverine, iododexetimide, methscopolamine",1.94309514866353,0.675717544702307,TRUE
+"HCC4006","Pearson.est","adenosine receptor antagonist",-0.36098,-0.929,0.525,1427,0.87,"istradefylline",0.279840696594043,0.0604807473813815,FALSE
+"HCC4006","Pearson.est","adrenergic receptor agonist",-0.4302,-1.12,0.318,1124,1,"xylazine, oxymetazoline, ritodrine, methyldopa, norepinephrine, isoetharine",0.497572880015567,0,FALSE
+"HCC4006","Pearson.est","adrenergic receptor antagonist",0.30409,0.788,0.709,207,0.876,"practolol, idazoxan, propranolol, vincamine",0.149353764816933,0.0574958938319193,FALSE
+"HCC4006","Pearson.est","AKT inhibitor",0.37209,0.967,0.48,473,0.95,"MK.2206, triciribine, ONC201, AT7867, palomid.529, GSK2110183",0.318758762624413,0.0222763947111523,FALSE
+"HCC4006","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.40024,-1.06,0.387,1223,1,"alectinib, CEP.37440, DMH1",0.412289034981089,0,FALSE
+"HCC4006","Pearson.est","androgen receptor antagonist",-0.75881,-1.96,0.00986,1231,0.132,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.00612308505879,0.87942606879415,TRUE
+"HCC4006","Pearson.est","antioxidant",-0.68448,-1.77,0.0297,1197,0.218,"benfotiamine, trolox",1.52724355068279,0.661543506395395,TRUE
+"HCC4006","Pearson.est","AP inhibitor",0.68634,1.77,0.0251,39,0.381,"birinapant, GDC.0152",1.60032627851896,0.419075024324381,FALSE
+"HCC4006","Pearson.est","ATPase inhibitor",0.42021,1.1,0.328,365,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.484126156288321,0,FALSE
+"HCC4006","Pearson.est","Aurora kinase inhibitor",0.32072,0.834,0.637,514,0.858,"MK.5108, barasertib, MK.8745, barasertib.HQPA, alisertib, ENMD.2076, PF.03814735, ZM.447439, MLN.8054, CCT137690, SNS.314, danusertib",0.19586056766465,0.0665127121512946,FALSE
+"HCC4006","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36395,-0.927,0.532,1330,0.844,"azalomycin.b, dirithromycin",0.274088367704952,0.073657553374345,FALSE
+"HCC4006","Pearson.est","bacterial DNA gyrase inhibitor",0.42883,1.15,0.282,333,1,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.549750891680639,0,FALSE
+"HCC4006","Pearson.est","BCL inhibitor",-0.38411,-0.988,0.456,1414,1,"gossypol, ABT.737",0.341035157335565,0,FALSE
+"HCC4006","Pearson.est","Bcr.Abl kinase inhibitor",0.32752,0.858,0.62,228,0.848,"dasatinib, metatinib, bafetinib",0.207608310501746,0.0716041477432862,FALSE
+"HCC4006","Pearson.est","benzodiazepine receptor agonist",0.42389,1.09,0.34,124,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.468521082957745,0,FALSE
+"HCC4006","Pearson.est","bromodomain inhibitor",-0.38352,-0.99,0.454,1171,1,"I.BET151, PFI.1",0.342944147142896,0,FALSE
+"HCC4006","Pearson.est","calcium channel blocker",-0.34927,-0.9,0.529,1103,0.84,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.276544327964814,0.0757207139381184,FALSE
+"HCC4006","Pearson.est","CC chemokine receptor antagonist",-0.25746,-0.673,0.854,371,0.927,"UNBS.5162, ZK811752, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.068542129310995,0.0329202658555029,FALSE
+"HCC4006","Pearson.est","CDK inhibitor",-0.25177,-0.647,0.854,884,0.935,"PHA.793887, BMS.387032, PHA.848125, palbociclib, arcyriaflavin.a, AZD5438, indirubin, R547, abemaciclib, ribociclib, BMS.265246, JNJ.7706621, TG.02",0.068542129310995,0.0291883891274822,FALSE
+"HCC4006","Pearson.est","CHK inhibitor",-0.41837,-1.07,0.363,1073,1,"SCH.900776, AZD7762, SB.218078",0.440093374963888,0,FALSE
+"HCC4006","Pearson.est","cyclooxygenase inhibitor",-0.3837,-0.981,0.454,1201,0.979,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.342944147142896,0.00921730819686218,FALSE
+"HCC4006","Pearson.est","cytochrome P450 inhibitor",0.63095,1.66,0.0459,205,0.486,"PF.4981517, morin, eplerenone",1.33818731446274,0.313363730737707,FALSE
+"HCC4006","Pearson.est","DNA alkylating agent",-0.35938,-0.934,0.512,1042,0.891,"TH.302, streptozotocin, melphalan, carmustine, satraplatin, cyclophosphamide, temozolomide",0.290730039024169,0.0501222959631252,FALSE
+"HCC4006","Pearson.est","DNA inhibitor",-0.25855,-0.676,0.856,1380,0.945,"nithiamide, pibenzimol",0.0675262353228468,0.0245681914907371,FALSE
+"HCC4006","Pearson.est","DNA methyltransferase inhibitor",0.63078,1.65,0.0466,469,0.385,"azacitidine, decitabine, SGI.1027, fdcyd",1.33161408331,0.414539270491499,FALSE
+"HCC4006","Pearson.est","DNA polymerase inhibitor",0.36547,0.962,0.481,155,0.866,"foscarnet, cephalomannine, cidofovir",0.317854923626168,0.0624821079826534,FALSE
+"HCC4006","Pearson.est","DNA synthesis inhibitor",-0.26713,-0.706,0.814,1315,0.949,"altretamine, enocitabine",0.0893755951107988,0.0227337875727074,FALSE
+"HCC4006","Pearson.est","dopamine receptor antagonist",-0.4069,-1.02,0.429,1190,1,"ziprasidone, remoxipride, mesoridazine, paliperidone, amisulpride, lurasidone",0.367542707815276,0,FALSE
+"HCC4006","Pearson.est","estrogen receptor agonist",-0.34421,-0.889,0.572,1243,0.808,"estrone, erteberel",0.242603971206976,0.0925886392254138,FALSE
+"HCC4006","Pearson.est","estrogen receptor antagonist",-0.8379,-2.17,0,1296,0.024,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.61978875828839,TRUE
+"HCC4006","Pearson.est","FGFR inhibitor",-0.39011,-1.03,0.389,1049,1,"MK.2461, nintedanib, lenvatinib, lucitanib",0.410050398674292,0,FALSE
+"HCC4006","Pearson.est","FLT3 inhibitor",-0.37259,-0.95,0.505,1164,0.927,"quizartinib, TG.101348, KW.2449, pacritinib, TG.02, sunitinib, lestaurtinib",0.296708621881339,0.0329202658555029,FALSE
+"HCC4006","Pearson.est","glucocorticoid receptor agonist",-0.35798,-0.925,0.521,893,0.82,"desonide, halobetasol.propionate, fludroxycortide, clobetasol.propionate, triamcinolone.acetonide, triamcinolone, halcinonide, prednisolone, flumethasone, rimexolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, flumethasone.pivalate, hydrocortisone, dexamethasone.acetate",0.283162276700476,0.0861861476162833,FALSE
+"HCC4006","Pearson.est","glutamate receptor antagonist",0.3356,0.861,0.616,192,0.877,"ACDPP, tiletamine, kynurenic.acid",0.210419287835575,0.0570004066339595,FALSE
+"HCC4006","Pearson.est","glycogen synthase kinase inhibitor",0.39916,1.03,0.405,49,1,"CHIR.99021",0.392544976785331,0,FALSE
+"HCC4006","Pearson.est","growth factor receptor inhibitor",-0.65521,-1.75,0.0278,1268,0.205,"GSK1838705A, GW.441756, lestaurtinib",1.55595520408192,0.688246138944246,TRUE
+"HCC4006","Pearson.est","HCV inhibitor",0.38379,1,0.448,66,1,"daclatasvir",0.348721986001856,0,FALSE
+"HCC4006","Pearson.est","HDAC inhibitor",0.43613,1.13,0.312,459,1,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, entinostat, M.344, resminostat, romidepsin, mocetinostat, givinostat, trichostatin.a",0.505845405981557,0,FALSE
+"HCC4006","Pearson.est","histamine receptor antagonist",-0.2654,-0.688,0.849,960,0.952,"lafutidine, cyproheptadine, ICI.162846, terfenadine, ranitidine, tiotidine, ebastine, BF2.649, epinastine",0.0710923097560473,0.0213630516155257,FALSE
+"HCC4006","Pearson.est","HMGCR inhibitor",0.36445,0.975,0.469,229,0.987,"atorvastatin, simvastatin",0.328827157284917,0.00568284733036327,FALSE
+"HCC4006","Pearson.est","HSP inhibitor",0.54031,1.43,0.0994,214,0.7,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, ganetespib, SNX.2112, SNX.5422",1.00261361560269,0.154901959985743,FALSE
+"HCC4006","Pearson.est","JAK inhibitor",-0.36271,-0.937,0.528,1109,0.919,"CEP.33779, TG.101348, pacritinib, filgotinib, AZD1480, TG.02, lestaurtinib",0.277366077466188,0.0366844886138887,FALSE
+"HCC4006","Pearson.est","KIT inhibitor",-0.28973,-0.757,0.768,1102,0.919,"imatinib, lenvatinib, KI.8751, vatalanib, telatinib, sunitinib, masitinib",0.114638779968488,0.0366844886138887,FALSE
+"HCC4006","Pearson.est","MDM inhibitor",-0.2418,-0.631,0.89,1012,0.93,"nutlin.3, CGM097, RITA",0.0506099933550872,0.0315170514460649,FALSE
+"HCC4006","Pearson.est","MEK inhibitor",-0.27467,-0.71,0.805,1142,0.967,"refametinib, MEK162, BIX.02188, nobiletin, arctigenin",0.0942041196321315,0.0145735259169983,FALSE
+"HCC4006","Pearson.est","MET inhibitor",-0.6435,-1.67,0.0511,1146,0.268,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.29157909986529,0.571865205971211,FALSE
+"HCC4006","Pearson.est","microtubule inhibitor",0.38045,0.965,0.478,454,0.904,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel",0.320572103387881,0.0438315695246367,FALSE
+"HCC4006","Pearson.est","mTOR inhibitor",0.69868,1.82,0.0149,226,0.552,"deforolimus, PI.103, AZD8055, torin.1, PKI.179, everolimus, temsirolimus, NVP.BEZ235, LY3023414, PP242, MLN0128, AZD2014, sirolimus, GDC.0980, SB.2343, torin.2, WYE.125132",1.82681373158773,0.258060922270801,FALSE
+"HCC4006","Pearson.est","NFkB pathway inhibitor",-0.39249,-1.04,0.388,1226,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.411168274405793,0,FALSE
+"HCC4006","Pearson.est","opioid receptor agonist",-0.43002,-1.11,0.323,1264,1,"ADL5859, salvinorin.a",0.490797477668897,0,FALSE
+"HCC4006","Pearson.est","p38 MAPK inhibitor",-0.22983,-0.597,0.907,1302,0.94,"skepinone.l",0.0423927129399047,0.0268721464003014,FALSE
+"HCC4006","Pearson.est","PARP inhibitor",-0.53205,-1.39,0.129,898,0.635,"niraparib, olaparib, PJ.34, AZD2461, AG.14361, talazoparib",0.889410289700751,0.197226274708024,FALSE
+"HCC4006","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.37345,-0.971,0.478,1102,0.958,"imatinib, axitinib, nintedanib, lenvatinib, KI.8751, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.320572103387881,0.0186344909214556,FALSE
+"HCC4006","Pearson.est","phosphatase inhibitor",-0.29531,-0.77,0.715,1157,0.922,"CID.5458317, menadione, alexidine",0.145693958198919,0.0352690789463706,FALSE
+"HCC4006","Pearson.est","phosphodiesterase inhibitor",0.21587,0.571,0.95,489,0.999,"papaverine, enoximone, EMD.53998, zardaverine, cilostamide",0.0222763947111523,0.000434511774017692,FALSE
+"HCC4006","Pearson.est","PI3K inhibitor",0.35094,0.897,0.552,185,0.877,"PI.103, PKI.179, NVP.BEZ235, LY3023414, BGT226, GDC.0980, SB.2343",0.258060922270801,0.0570004066339595,FALSE
+"HCC4006","Pearson.est","PLK inhibitor",0.34074,0.872,0.614,957,0.892,"HMN.214, BI.2536, rigosertib, volasertib, GSK461364, NMS.1286937, GW.843682X",0.211831628858832,0.0496351456238769,FALSE
+"HCC4006","Pearson.est","potassium channel blocker",0.56314,1.44,0.11,476,0.807,"ML133, ibutilide, oleoylethanolamide, dofetilide, mepivacaine",0.958607314841775,0.0931264652779296,FALSE
+"HCC4006","Pearson.est","PPAR receptor agonist",-0.31713,-0.814,0.675,1406,0.896,"fenofibrate",0.170696227168975,0.0476919903378748,FALSE
+"HCC4006","Pearson.est","progesterone receptor agonist",-0.55188,-1.44,0.108,1081,0.586,"norgestrel, dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",0.96657624451305,0.232102383981909,FALSE
+"HCC4006","Pearson.est","proteasome inhibitor",0.36017,0.954,0.524,206,0.841,"ONX.0914, MG.132",0.280668713016273,0.0752040042020878,FALSE
+"HCC4006","Pearson.est","protein synthesis inhibitor",0.28052,0.721,0.781,405,0.92,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, methacycline, azomycin..2.nitroimidazole.",0.1073489661227,0.0362121726544447,FALSE
+"HCC4006","Pearson.est","protein tyrosine kinase inhibitor",-0.32632,-0.842,0.627,1363,0.871,"CP.724714, rheochrysidin",0.202732459169284,0.0599818449923368,FALSE
+"HCC4006","Pearson.est","RAF inhibitor",0.40094,1.06,0.381,510,1,"SB.590885, vemurafenib, sorafenib, LGX818, AZ.628, dabrafenib, PLX.4720, regorafenib",0.419075024324381,0,FALSE
+"HCC4006","Pearson.est","RET tyrosine kinase inhibitor",-0.37305,-0.959,0.469,1392,0.945,"sunitinib",0.328827157284917,0.0245681914907371,FALSE
+"HCC4006","Pearson.est","retinoid receptor agonist",0.31541,0.812,0.684,63,0.865,"LE.135",0.164943898279884,0.0629838925351858,FALSE
+"HCC4006","Pearson.est","ribonucleotide reductase inhibitor",-0.39798,-1.03,0.388,1441,1,"pentostatin",0.411168274405793,0,FALSE
+"HCC4006","Pearson.est","serotonin receptor agonist",-0.70773,-1.82,0.0196,1348,0.194,"zolmitriptan, ipsapirone, aripiprazole",1.70774392864352,0.712198270069774,TRUE
+"HCC4006","Pearson.est","serotonin receptor antagonist",-0.41143,-1.07,0.368,1397,1,"lurasidone, aripiprazole",0.434152181326482,0,FALSE
+"HCC4006","Pearson.est","sodium channel blocker",0.29456,0.769,0.728,476,0.877,"brivaracetam, ajmaline, cibenzoline, mexiletine, butamben, mepivacaine",0.137868620686963,0.0570004066339595,FALSE
+"HCC4006","Pearson.est","src inhibitor",-0.34039,-0.892,0.561,1055,0.827,"bosutinib, PP.1, PP.2, masitinib",0.251037138743839,0.0824944904474534,FALSE
+"HCC4006","Pearson.est","sterol demethylase inhibitor",0.3633,0.951,0.504,10,0.809,"chlormidazole",0.297569463554475,0.0920514783877277,FALSE
+"HCC4006","Pearson.est","TGF beta receptor inhibitor",-0.63419,-1.63,0.0567,1003,0.289,"adaprev, repsox, SB.431542, SB.525334, D.4476",1.24641694110709,0.539102157243452,FALSE
+"HCC4006","Pearson.est","thymidylate synthase inhibitor",-0.32316,-0.806,0.667,466,0.885,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.175874166083451,0.0530567293021746,FALSE
+"HCC4006","Pearson.est","topoisomerase inhibitor",0.26898,0.705,0.832,247,0.913,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate, amsacrine",0.0798766737092761,0.039529222465701,FALSE
+"HCC4006","Pearson.est","tubulin polymerization inhibitor",0.40614,1.06,0.365,463,1,"epothilone.b, BNC105, mebendazole, oxibendazole, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, dolastatin.10, podophyllotoxin, plinabulin, KX2.391",0.437707135543525,0,FALSE
+"HCC4006","Pearson.est","tyrosine kinase inhibitor",-0.22203,-0.578,0.945,1363,0.935,"CP.724714, sunitinib, rheochrysidin",0.0245681914907371,0.0291883891274822,FALSE
+"HCC4006","Pearson.est","VEGFR inhibitor",0.20175,0.534,0.963,100,0.965,"BMS.690514, OSI.930, SAR131675, XL.647",0.0163737128754655,0.0154726866562074,FALSE
+"HCC4006","Pearson.est","vitamin D receptor agonist",0.48744,1.26,0.201,400,1,"ercalcitriol, calcitriol, maxacalcitol",0.696803942579511,0,FALSE
+"HCC2279","Pearson.est","EGFR inhibitor",0.43915,1.11,0.333,373,0.925,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, WZ.3146, canertinib, AST.1306, gefitinib, brigatinib, BIBU.1361, PD.168393, BIBX.1382, icotinib, pelitinib, afatinib, AZD8931, lapatinib, osimertinib",0.47755576649368,0.0338582672609674,FALSE
+"HCC2279","Pearson.est","Abl kinase inhibitor",0.35954,0.925,0.545,222,0.888,"metatinib, dasatinib, bafetinib",0.263603497723358,0.051587034221399,FALSE
+"HCC2279","Pearson.est","acetylcholine receptor agonist",0.2858,0.737,0.804,88,0.896,"xanomeline",0.0947439512515487,0.0476919903378748,FALSE
+"HCC2279","Pearson.est","acetylcholine receptor antagonist",-0.74317,-1.98,0.00232,1280,0.122,"dicycloverine, methscopolamine, iododexetimide",2.6345120151091,0.913640169325252,TRUE
+"HCC2279","Pearson.est","adenosine receptor antagonist",0.42261,1.07,0.372,128,0.871,"theophylline, PSB.1115",0.429457060118102,0.0599818449923368,FALSE
+"HCC2279","Pearson.est","adrenergic receptor agonist",-0.4041,-1.07,0.36,1115,1,"xylazine, oxymetazoline, methyldopa, ritodrine, norepinephrine, isoetharine",0.443697499232713,0,FALSE
+"HCC2279","Pearson.est","adrenergic receptor antagonist",0.3217,0.81,0.667,217,0.905,"practolol, idazoxan, vincamine, propranolol",0.175874166083451,0.0433514207947967,FALSE
+"HCC2279","Pearson.est","AKT inhibitor",0.42308,1.07,0.368,485,0.871,"MK.2206, triciribine, AT7867, palomid.529, ONC201, GSK2110183",0.434152181326482,0.0599818449923368,FALSE
+"HCC2279","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.28665,-0.754,0.741,1206,0.947,"alectinib, CEP.37440, DMH1",0.130181792020672,0.0236500209967266,FALSE
+"HCC2279","Pearson.est","androgen receptor antagonist",-0.74422,-1.93,0.00696,1229,0.121,"flutamide, nilutamide, enzalutamide, cyproterone.acetate",2.15739076038944,0.91721462968355,TRUE
+"HCC2279","Pearson.est","antioxidant",-0.62691,-1.72,0.0411,1149,0.214,"benfotiamine, trolox",1.38615817812393,0.669586226650809,TRUE
+"HCC2279","Pearson.est","AP inhibitor",0.62245,1.54,0.0614,82,0.752,"birinapant, GDC.0152",1.21183162885883,0.123782159408358,FALSE
+"HCC2279","Pearson.est","ATPase inhibitor",0.45017,1.14,0.287,321,0.97,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, NMS.873, blebbistatin....",0.542118103266008,0.0132282657337552,FALSE
+"HCC2279","Pearson.est","Aurora kinase inhibitor",0.40273,1.03,0.415,438,0.839,"MK.8745, barasertib.HQPA, barasertib, alisertib, ENMD.2076, MK.5108, ZM.447439, CCT137690, PF.03814735, danusertib, SNS.314",0.381951903287907,0.0762380391712997,FALSE
+"HCC2279","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30116,0.759,0.735,152,0.91,"tedizolid, azithromycin",0.133712660915805,0.0409586076789064,FALSE
+"HCC2279","Pearson.est","bacterial DNA gyrase inhibitor",0.30787,0.784,0.718,457,0.896,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.1438755557577,0.0476919903378748,FALSE
+"HCC2279","Pearson.est","BCL inhibitor",0.35658,0.903,0.571,331,0.871,"oridonin, obatoclax, TW.37, venetoclax, HA14.1",0.243363891754152,0.0599818449923368,FALSE
+"HCC2279","Pearson.est","Bcr.Abl kinase inhibitor",0.41744,1.07,0.377,222,0.871,"metatinib, dasatinib, bafetinib",0.423658649794207,0.0599818449923368,FALSE
+"HCC2279","Pearson.est","benzodiazepine receptor agonist",0.45361,1.18,0.256,116,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.59176003468815,0,FALSE
+"HCC2279","Pearson.est","bromodomain inhibitor",-0.35488,-0.931,0.53,1120,0.929,"I.BET151, PFI.1",0.275724130399211,0.0319842860063582,FALSE
+"HCC2279","Pearson.est","calcium channel blocker",-0.31383,-0.828,0.626,1100,0.946,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.20342566678957,0.0241088635982073,FALSE
+"HCC2279","Pearson.est","CC chemokine receptor antagonist",-0.30396,-0.811,0.663,438,0.91,"UNBS.5162, ZK811752, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.178486471595227,0.0409586076789064,FALSE
+"HCC2279","Pearson.est","CDK inhibitor",0.22682,0.578,0.934,437,0.937,"alvocidib, NU6027, P276.00, AT.7519, dinaciclib, CR8..R., kenpaullone, aminopurvalanol.a",0.0296531237699066,0.0282604091122217,FALSE
+"HCC2279","Pearson.est","CHK inhibitor",-0.37942,-1.02,0.417,1148,0.972,"SCH.900776, AZD7762, SB.218078",0.379863945026242,0.0123337350737254,FALSE
+"HCC2279","Pearson.est","cyclooxygenase inhibitor",-0.40169,-1.05,0.366,1228,1,"acetylsalicylsalicylic.acid, AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.436518914605589,0,FALSE
+"HCC2279","Pearson.est","cytochrome P450 inhibitor",0.57356,1.42,0.115,253,0.871,"PF.4981517, morin, eplerenone",0.939302159646388,0.0599818449923368,FALSE
+"HCC2279","Pearson.est","DNA alkylating agent",-0.29599,-0.782,0.714,1041,0.933,"melphalan, carmustine, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.146301788223826,0.0301183562535,FALSE
+"HCC2279","Pearson.est","DNA inhibitor",-0.23623,-0.617,0.903,1041,0.929,"melphalan, metronidazole, carmustine, busulfan, pibenzimol, nithiamide",0.0443122496864942,0.0319842860063582,FALSE
+"HCC2279","Pearson.est","DNA methyltransferase inhibitor",0.65815,1.65,0.0358,392,0.809,"azacitidine, SGI.1027, decitabine, fdcyd",1.44611697335613,0.0920514783877277,FALSE
+"HCC2279","Pearson.est","DNA polymerase inhibitor",0.46568,1.17,0.276,210,1,"foscarnet, cephalomannine, cidofovir, idoxuridine",0.559090917934782,0,FALSE
+"HCC2279","Pearson.est","DNA synthesis inhibitor",-0.34519,-0.916,0.522,1406,0.919,"altretamine, enocitabine",0.282329496997738,0.0366844886138887,FALSE
+"HCC2279","Pearson.est","dopamine receptor antagonist",-0.37798,-0.995,0.422,1028,0.922,"clebopride, nemonapride, mesoridazine, ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.374687549038326,0.0352690789463706,FALSE
+"HCC2279","Pearson.est","estrogen receptor agonist",-0.31267,-0.812,0.643,1130,0.941,"ethinyl.estradiol, estrone, erteberel",0.191789027075778,0.0264103765727431,FALSE
+"HCC2279","Pearson.est","estrogen receptor antagonist",-0.79704,-2.1,0.00248,1307,0.095,"danazol, raloxifene, fulvestrant, tamoxifen",2.60554831917378,1.02227639471115,TRUE
+"HCC2279","Pearson.est","FGFR inhibitor",-0.26217,-0.686,0.82,377,0.879,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, nintedanib, MK.2461, lenvatinib, lucitanib",0.0861861476162833,0.0560111249262281,FALSE
+"HCC2279","Pearson.est","FLT3 inhibitor",-0.28707,-0.744,0.731,1171,0.932,"TG.101348, KW.2449, quizartinib, TG.02, lestaurtinib, sunitinib",0.13608262304214,0.0305840876460186,FALSE
+"HCC2279","Pearson.est","glucocorticoid receptor agonist",-0.35201,-0.938,0.518,928,0.958,"clobetasol.propionate, ciclesonide, fludroxycortide, flumethasone, halcinonide, desonide, triamcinolone, rimexolone, prednisolone, triamcinolone.acetonide, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.285670240254767,0.0186344909214556,FALSE
+"HCC2279","Pearson.est","glutamate receptor antagonist",0.33881,0.884,0.592,316,0.849,"ACDPP, tiletamine, kynurenic.acid, CGP.37849",0.22767829327708,0.0710923097560473,FALSE
+"HCC2279","Pearson.est","glycogen synthase kinase inhibitor",0.41156,1.05,0.367,33,0.831,"CHIR.99021",0.435333935747911,0.080398976215889,FALSE
+"HCC2279","Pearson.est","growth factor receptor inhibitor",-0.49468,-1.31,0.16,1353,0.664,"GW.441756, lestaurtinib",0.795880017344075,0.177831920631982,FALSE
+"HCC2279","Pearson.est","HCV inhibitor",0.36262,0.924,0.526,70,0.858,"daclatasvir",0.279014255846261,0.0665127121512946,FALSE
+"HCC2279","Pearson.est","HDAC inhibitor",0.47665,1.21,0.249,288,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, M.344, entinostat, resminostat",0.603800652904264,0,FALSE
+"HCC2279","Pearson.est","histamine receptor antagonist",-0.27106,-0.714,0.816,1019,0.891,"ICI.162846, lafutidine, cyproheptadine, tiotidine, terfenadine, ebastine, ranitidine, BF2.649, epinastine",0.0883098412461389,0.0501222959631252,FALSE
+"HCC2279","Pearson.est","HMGCR inhibitor",0.35543,0.89,0.586,243,0.866,"atorvastatin, simvastatin",0.232102383981909,0.0624821079826534,FALSE
+"HCC2279","Pearson.est","HSP inhibitor",0.58732,1.5,0.0687,204,0.73,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, SNX.2112, ganetespib, SNX.5422",1.16304326294045,0.136677139879544,FALSE
+"HCC2279","Pearson.est","JAK inhibitor",-0.30761,-0.832,0.638,1171,0.976,"TG.101348, CEP.33779, filgotinib, AZD1480, TG.02, lestaurtinib",0.195179321278838,0.0105501823333082,FALSE
+"HCC2279","Pearson.est","KIT inhibitor",0.26336,0.683,0.848,218,0.922,"midostaurin, OSI.930, dasatinib, sorafenib",0.0716041477432862,0.0352690789463706,FALSE
+"HCC2279","Pearson.est","MDM inhibitor",-0.27601,-0.742,0.762,398,0.906,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.1180450286604,0.0428718023231869,FALSE
+"HCC2279","Pearson.est","MEK inhibitor",-0.31578,-0.843,0.622,1136,0.994,"PD.318088, nobiletin, refametinib, BIX.02188, MEK162, arctigenin",0.206209615309181,0.00261361560268669,FALSE
+"HCC2279","Pearson.est","MET inhibitor",-0.63067,-1.68,0.0302,1065,0.227,"PF.04217903, INC.280, PHA.665752, NVP.BVU972, AMG458",1.51999305704285,0.643974142806877,TRUE
+"HCC2279","Pearson.est","microtubule inhibitor",0.44887,1.15,0.308,460,1,"estramustine.phosphate, triclabendazole, D.64131, cabazitaxel, podophyllotoxin",0.511449283499556,0,FALSE
+"HCC2279","Pearson.est","mTOR inhibitor",0.69425,1.76,0.0186,198,0.777,"deforolimus, PI.103, AZD8055, PKI.179, everolimus, temsirolimus, torin.1, NVP.BEZ235, LY3023414, MLN0128, AZD2014, PP242, torin.2, GDC.0980, WYE.125132, sirolimus",1.73048705578208,0.109578981199086,FALSE
+"HCC2279","Pearson.est","NFkB pathway inhibitor",-0.36824,-0.981,0.47,1210,0.905,"Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.327902142064283,0.0433514207947967,FALSE
+"HCC2279","Pearson.est","opioid receptor agonist",-0.42367,-1.11,0.344,1278,1,"ADL5859, salvinorin.a",0.46344155742847,0,FALSE
+"HCC2279","Pearson.est","p38 MAPK inhibitor",-0.21537,-0.581,0.936,1015,0.934,"CMPD.1, TAK.715, skepinone.l",0.0287241512618947,0.0296531237699066,FALSE
+"HCC2279","Pearson.est","PARP inhibitor",-0.55559,-1.46,0.112,986,0.504,"olaparib, niraparib, AZD2461, AG.14361, talazoparib",0.950781977329818,0.297569463554475,FALSE
+"HCC2279","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.27351,-0.707,0.804,1118,0.875,"axitinib, KI.8751, lenvatinib, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.0947439512515487,0.0579919469776868,FALSE
+"HCC2279","Pearson.est","phosphatase inhibitor",-0.27238,-0.721,0.751,1424,0.909,"alexidine",0.124360062995832,0.0414361167780325,FALSE
+"HCC2279","Pearson.est","phosphodiesterase inhibitor",0.26533,0.678,0.843,428,0.907,"papaverine, enoximone, EMD.53998, cilostamide",0.0741724253752577,0.0423927129399047,FALSE
+"HCC2279","Pearson.est","PI3K inhibitor",0.37559,0.952,0.504,371,0.9,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, ZSTK.474, voxtalisib, buparlisib, SB.2343, PF.04691502",0.297569463554475,0.0457574905606751,FALSE
+"HCC2279","Pearson.est","PLK inhibitor",0.42401,1.05,0.402,837,0.831,"HMN.214, BI.2536, volasertib, NMS.1286937, rigosertib, GSK461364, GW.843682X",0.39577394691553,0.080398976215889,FALSE
+"HCC2279","Pearson.est","potassium channel blocker",0.6142,1.54,0.059,397,0.752,"ML133, ibutilide, mepivacaine, dofetilide, oleoylethanolamide",1.22914798835786,0.123782159408358,FALSE
+"HCC2279","Pearson.est","PPAR receptor agonist",-0.39076,-1.04,0.377,1147,0.984,"clofibrate, S26948, fenofibrate",0.423658649794207,0.00700490156865849,FALSE
+"HCC2279","Pearson.est","progesterone receptor agonist",-0.69261,-1.81,0.0183,1209,0.161,"dienogest, norgestrel, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.73754891026957,0.79317412396815,TRUE
+"HCC2279","Pearson.est","proteasome inhibitor",0.437,1.12,0.32,135,0.959,"ONX.0914, MG.132",0.494850021680094,0.0181813928293364,FALSE
+"HCC2279","Pearson.est","protein synthesis inhibitor",0.24222,0.613,0.901,585,0.952,"clofoctol, cycloheximide, puromycin, thiostrepton, brefeldin.a, methacycline, azomycin..2.nitroimidazole., anguidine, homoharringtonine, chloramphenicol.palmitate",0.045275209020937,0.0213630516155257,FALSE
+"HCC2279","Pearson.est","protein tyrosine kinase inhibitor",0.3168,0.806,0.71,357,0.885,"AV.412, NVP.TAE226, mubritinib, tyrphostin.A9",0.148741651280925,0.0530567293021746,FALSE
+"HCC2279","Pearson.est","RAF inhibitor",0.47626,1.21,0.243,434,1,"SB.590885, vemurafenib, sorafenib, dabrafenib, LGX818, AZ.628, regorafenib",0.614393726401688,0,FALSE
+"HCC2279","Pearson.est","RET tyrosine kinase inhibitor",0.32383,0.828,0.667,481,0.927,"sorafenib, regorafenib, apatinib, vandetanib",0.175874166083451,0.0329202658555029,FALSE
+"HCC2279","Pearson.est","retinoid receptor agonist",0.29587,0.752,0.755,76,0.897,"LE.135",0.122053048370812,0.0472075569559079,FALSE
+"HCC2279","Pearson.est","ribonucleotide reductase inhibitor",-0.37302,-1.01,0.433,1437,0.939,"pentostatin",0.363512103646635,0.0273344077338891,FALSE
+"HCC2279","Pearson.est","serotonin receptor agonist",-0.68958,-1.82,0.0167,1213,0.189,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",1.77728352885242,0.723538195826756,TRUE
+"HCC2279","Pearson.est","serotonin receptor antagonist",-0.39765,-1.06,0.39,1380,1,"lurasidone, aripiprazole",0.408935392973501,0,FALSE
+"HCC2279","Pearson.est","sodium channel blocker",0.37315,0.964,0.471,456,0.95,"brivaracetam, ajmaline, butamben, mepivacaine, cibenzoline, mexiletine",0.326979092871104,0.0222763947111523,FALSE
+"HCC2279","Pearson.est","src inhibitor",-0.32003,-0.854,0.613,1272,1,"PP.2, masitinib",0.212539525481585,0,FALSE
+"HCC2279","Pearson.est","sterol demethylase inhibitor",0.37122,0.933,0.52,11,0.906,"chlormidazole",0.283996656365201,0.0428718023231869,FALSE
+"HCC2279","Pearson.est","TGF beta receptor inhibitor",-0.51439,-1.31,0.172,1006,0.664,"repsox, adaprev, SB.431542, D.4476, SB.525334",0.764471553092451,0.177831920631982,FALSE
+"HCC2279","Pearson.est","thymidylate synthase inhibitor",0.3766,0.952,0.49,671,0.9,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine",0.309803919971486,0.0457574905606751,FALSE
+"HCC2279","Pearson.est","topoisomerase inhibitor",0.27081,0.698,0.836,157,0.926,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate",0.0777937225609836,0.0333890133180656,FALSE
+"HCC2279","Pearson.est","tubulin polymerization inhibitor",0.45344,1.14,0.302,566,0.97,"epothilone.b, mebendazole, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, plinabulin, parbendazole, dolastatin.10, KX2.391, podophyllotoxin, combretastatin.A.4, vindesine, paclitaxel, ABT.751",0.519993057042849,0.0132282657337552,FALSE
+"HCC2279","Pearson.est","tyrosine kinase inhibitor",0.32461,0.821,0.686,517,0.912,"AV.412, dasatinib, NVP.TAE226, sorafenib, bafetinib, mubritinib, tivantinib, tyrphostin.A9, regorafenib, apatinib, aminopurvalanol.a, vandetanib, PP.121, GTP.14564",0.163675884293248,0.0400051616715838,FALSE
+"HCC2279","Pearson.est","VEGFR inhibitor",0.23293,0.587,0.936,223,0.952,"BMS.690514, OSI.930, XL.647, SAR131675, sorafenib, ENMD.2076",0.0287241512618947,0.0213630516155257,FALSE
+"HCC2279","Pearson.est","vitamin D receptor agonist",0.55351,1.4,0.117,570,0.812,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol, doxercalciferol",0.931814138253838,0.0904439707588247,FALSE
+"H520","Pearson.est","EGFR inhibitor",0.3785,1,0.438,413,1,"CUDC.101, ARRY.334543, BMS.690514, tyrphostin.AG.1478, erlotinib, XL.647, brigatinib, WZ.3146, canertinib, gefitinib, PD.168393, BIBU.1361, icotinib, AST.1306, BIBX.1382, afatinib, pelitinib, vandetanib, lapatinib, rociletinib, osimertinib",0.3585258894959,0,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",0.38038,0.992,0.464,149,0.918,"dasatinib, metatinib, bafetinib",0.333482019445119,0.0371573187987575,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",-0.21849,-0.574,0.934,1154,1,"pilocarpine, nicotine",0.0296531237699066,0,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",-0.76136,-1.96,0.00832,1308,0.12,"dicycloverine, iododexetimide, methscopolamine",2.07987667370928,0.920818753952375,TRUE
+"H520","Pearson.est","adenosine receptor antagonist",-0.34721,-0.882,0.552,1422,0.951,"istradefylline",0.258060922270801,0.0218194830625861,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",-0.3918,-0.993,0.451,1253,1,"methyldopa, ritodrine, norepinephrine, isoetharine",0.345823458122039,0,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",0.31608,0.82,0.682,207,0.878,"practolol, idazoxan, vincamine, propranolol",0.166215625343521,0.0565054840938974,FALSE
+"H520","Pearson.est","AKT inhibitor",0.36932,0.966,0.498,516,0.885,"triciribine, MK.2206, ONC201, palomid.529, AT7867, GSK2110183",0.302770657240282,0.0530567293021746,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25973,-0.665,0.858,1307,1,"CEP.37440, DMH1",0.0665127121512946,0,FALSE
+"H520","Pearson.est","androgen receptor antagonist",-0.74075,-1.86,0.0217,1080,0.18,"bicalutamide, nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.66354026615147,0.744727494896694,TRUE
+"H520","Pearson.est","antioxidant",-0.61441,-1.6,0.0496,1141,0.428,"benfotiamine, trolox",1.3045183235098,0.368556230986828,FALSE
+"H520","Pearson.est","AP inhibitor",0.68708,1.75,0.026,52,0.854,"birinapant, GDC.0152",1.58502665202918,0.068542129310995,FALSE
+"H520","Pearson.est","ATPase inhibitor",0.41974,1.06,0.379,401,0.989,"k.strophanthidin, oligomycin.a, evodiamine, blebbistatin...., ouabain, thonzonium, NMS.873",0.421360790031928,0.0048037084028206,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",0.31032,0.782,0.716,508,0.801,"MK.5108, barasertib.HQPA, barasertib, MK.8745, ENMD.2076, alisertib, PF.03814735, ZM.447439, CCT137690, MLN.8054, hesperadin, SNS.314",0.145086977692144,0.0963674839157623,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34519,-0.881,0.594,1322,0.92,"azalomycin.b, dirithromycin",0.226213555018806,0.0362121726544447,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.36667,0.918,0.524,340,0.902,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.280668713016273,0.0447934624580583,FALSE
+"H520","Pearson.est","BCL inhibitor",0.38335,0.989,0.472,306,0.877,"oridonin, TW.37, HA14.1, obatoclax, venetoclax",0.326058001365912,0.0570004066339595,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.42427,1.13,0.314,149,1,"dasatinib, metatinib, bafetinib",0.503070351926785,0,FALSE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.41145,1.07,0.33,136,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.481486060122112,0,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.51138,-1.34,0.156,1242,0.669,"PFI.1, I.BET151",0.806875401645538,0.174573882232177,FALSE
+"H520","Pearson.est","calcium channel blocker",-0.38234,-0.966,0.487,1120,0.995,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.312471038785366,0.00217691925427455,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",-0.24983,-0.654,0.875,360,0.974,"UNBS.5162, ZK811752, MK.0812, RS.504393, navarixin, SB.225002, PF.04136309",0.0579919469776868,0.0114410431213845,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.20338,-0.532,0.967,954,0.963,"arcyriaflavin.a, abemaciclib, AZD5438, R547, indirubin, ribociclib, JNJ.7706621, BMS.265246, TG.02",0.0145735259169983,0.0163737128754655,FALSE
+"H520","Pearson.est","CHK inhibitor",-0.21786,-0.551,0.967,1327,0.974,"SB.218078",0.0145735259169983,0.0114410431213845,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",-0.40428,-1.05,0.385,1274,0.928,"AM.404, tryptanthrin, FR.122047, piroxicam, naproxen",0.414539270491499,0.0324520237811379,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.57695,1.49,0.0812,183,0.559,"PF.4981517, morin, eplerenone",1.09044397075882,0.252588192113577,FALSE
+"H520","Pearson.est","DNA alkylating agent",-0.27267,-0.692,0.842,984,0.999,"mitomycin.c, carmustine, streptozotocin, melphalan, cyclophosphamide, satraplatin, temozolomide",0.0746879085003505,0.000434511774017692,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.24891,-0.637,0.895,1084,0.969,"melphalan, metronidazole, busulfan, pibenzimol, nithiamide",0.048176964684088,0.0136762229492347,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",0.66149,1.69,0.0296,451,0.418,"decitabine, azacitidine, SGI.1027, fdcyd",1.52870828894106,0.378823718224965,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",0.33928,0.86,0.602,289,0.904,"foscarnet, cephalomannine, cidofovir, idoxuridine",0.220403508742175,0.0438315695246367,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.27852,-0.721,0.775,952,1,"azodicarbonamide, anisomycin, mitomycin.c, CB.10.277, artesunate, altretamine, enocitabine",0.11069829749369,0,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",-0.41706,-1.08,0.354,1177,0.908,"mesoridazine, ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.450996737974212,0.0419141514789149,FALSE
+"H520","Pearson.est","estrogen receptor agonist",-0.36956,-0.976,0.466,1275,1,"estrone, erteberel",0.33161408331,0,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",-0.82569,-2.1,0,1244,0.0746,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.12726117252733,TRUE
+"H520","Pearson.est","FGFR inhibitor",-0.3032,-0.79,0.705,436,0.978,"orantinib, AZD4547, erdafitinib, regorafenib, dovitinib, PD.173074, nintedanib, MK.2461, lenvatinib, lucitanib",0.151810883008601,0.00966114521239857,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.3603,-0.924,0.535,1228,0.968,"TG.101348, pacritinib, quizartinib, TG.02, sunitinib, lestaurtinib",0.271646217978772,0.0141246426916063,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",-0.45101,-1.16,0.275,1026,0.934,"flumethasone, halcinonide, triamcinolone, desonide, triamcinolone.acetonide, prednisolone, beclomethasone.dipropionate, prednisolone.acetate, rimexolone, fluticasone.propionate, fluocinolone.acetonide, piretanide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.560667306169737,0.0296531237699066,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",0.30263,0.791,0.697,236,0.839,"ACDPP, kynurenic.acid, tiletamine",0.156767221901991,0.0762380391712997,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.35796,0.951,0.487,48,0.874,"CHIR.99021",0.312471038785366,0.058488567365597,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.55484,-1.4,0.131,1356,0.671,"GW.441756, lestaurtinib",0.882728704344236,0.173277479831008,FALSE
+"H520","Pearson.est","HCV inhibitor",0.32196,0.84,0.639,60,0.872,"daclatasvir",0.1944991418416,0.0594835150674328,FALSE
+"H520","Pearson.est","HDAC inhibitor",0.48026,1.24,0.228,324,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, ACY.1215, scriptaid, entinostat, resminostat, M.344, romidepsin",0.642065152999546,0,FALSE
+"H520","Pearson.est","histamine receptor antagonist",-0.25225,-0.655,0.87,923,0.997,"nizatidine, lafutidine, cyproheptadine, tiotidine, ICI.162846, terfenadine, ebastine, ranitidine, BF2.649, epinastine",0.0604807473813815,0.00130484168834428,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.3774,0.993,0.431,198,0.97,"atorvastatin, simvastatin",0.365522729839268,0.0132282657337552,FALSE
+"H520","Pearson.est","HSP inhibitor",0.57377,1.51,0.0998,184,0.617,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, SNX.5422, ganetespib",1.00086945871263,0.209714835966758,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.45606,-1.16,0.282,1228,0.934,"TG.101348, pacritinib, CEP.33779, AZD1480, filgotinib, TG.02, lestaurtinib",0.549750891680639,0.0296531237699066,FALSE
+"H520","Pearson.est","KIT inhibitor",0.28105,0.735,0.749,88,0.816,"midostaurin, dasatinib, OSI.930",0.125518182300534,0.0883098412461389,FALSE
+"H520","Pearson.est","MDM inhibitor",-0.44364,-1.15,0.32,1104,0.897,"nutlin.3, CGM097, RITA",0.494850021680094,0.0472075569559079,FALSE
+"H520","Pearson.est","MEK inhibitor",-0.21787,-0.565,0.936,1074,0.987,"refametinib, PD.318088, nobiletin, MEK162, BIX.02188, arctigenin",0.0287241512618947,0.00568284733036327,FALSE
+"H520","Pearson.est","MET inhibitor",-0.5436,-1.39,0.149,1061,0.623,"INC.280, PHA.665752, NVP.BVU972, AMG458",0.826813731587726,0.20551195334083,FALSE
+"H520","Pearson.est","microtubule inhibitor",0.34835,0.896,0.562,209,0.908,"estramustine.phosphate, triclabendazole",0.250263684430939,0.0419141514789149,FALSE
+"H520","Pearson.est","mTOR inhibitor",0.67774,1.73,0.0193,227,0.48,"deforolimus, PI.103, everolimus, temsirolimus, AZD8055, NVP.BEZ235, PKI.179, torin.1, MLN0128, LY3023414, AZD2014, GDC.0980, PP242, torin.2, sirolimus, SB.2343",1.71444269099223,0.318758762624413,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",-0.36892,-0.951,0.481,1075,0.988,"Ro.106.9920, IKK.2.inhibitor.V, tyloxapol, bindarit, parthenolide, betulinic.acid",0.317854923626168,0.00524305541237188,FALSE
+"H520","Pearson.est","opioid receptor agonist",-0.46935,-1.21,0.259,1265,0.938,"ADL5859, salvinorin.a",0.586700235918748,0.0277971616209356,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.27164,-0.699,0.8,1344,1,"skepinone.l",0.0969100130080564,0,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.5499,-1.46,0.0782,839,0.682,"PJ.34, olaparib, E7449, AZD2461, niraparib, AG.14361, talazoparib",1.10679324694015,0.166215625343521,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.2951,-0.779,0.721,1038,0.968,"crenolanib, imatinib, KI.8751, axitinib, lenvatinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.142064735280571,0.0141246426916063,FALSE
+"H520","Pearson.est","phosphatase inhibitor",-0.31777,-0.805,0.717,1203,0.979,"CID.5458317, menadione, alexidine",0.1444808443322,0.00921730819686218,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",0.31336,0.807,0.707,261,0.84,"papaverine, enoximone, EMD.53998",0.150580586203101,0.0757207139381184,FALSE
+"H520","Pearson.est","PI3K inhibitor",0.3974,1.03,0.414,230,1,"PI.103, NVP.BEZ235, PKI.179, LY3023414, BGT226, GDC.0980, SB.2343, ZSTK.474",0.382999658879101,0,FALSE
+"H520","Pearson.est","PLK inhibitor",0.33727,0.841,0.62,962,0.904,"HMN.214, BI.2536, volasertib, GSK461364, rigosertib, GW.843682X, NMS.1286937",0.207608310501746,0.0438315695246367,FALSE
+"H520","Pearson.est","potassium channel blocker",0.62432,1.65,0.0584,423,0.384,"ML133, ibutilide, mepivacaine, dofetilide, oleoylethanolamide",1.2335871528876,0.415668775632469,FALSE
+"H520","Pearson.est","PPAR receptor agonist",-0.36332,-0.944,0.476,1419,0.963,"fenofibrate",0.322393047279507,0.0163737128754655,FALSE
+"H520","Pearson.est","progesterone receptor agonist",-0.7201,-1.83,0.0141,1161,0.135,"norgestrel, nomegestrol.acetate, danazol, dienogest, melengestrol.acetate, norethindrone.acetate",1.85078088734462,0.869666231504994,TRUE
+"H520","Pearson.est","proteasome inhibitor",0.44222,1.14,0.313,416,1,"ONX.0914, MG.132, carfilzomib, delanzomib",0.504455662453552,0,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",0.30016,0.783,0.699,253,0.824,"clofoctol, cycloheximide, puromycin, brefeldin.a, thiostrepton",0.155522824254319,0.0840727883028842,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.34542,-0.895,0.583,1376,0.995,"CP.724714, rheochrysidin",0.234331445240986,0.00217691925427455,FALSE
+"H520","Pearson.est","RAF inhibitor",0.47834,1.23,0.232,336,0.945,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.6345120151091,0.0245681914907371,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.3001,-0.765,0.734,1355,0.964,"sunitinib",0.134303940083929,0.0159229660971692,FALSE
+"H520","Pearson.est","retinoid receptor agonist",0.42832,1.1,0.337,27,1,"LE.135",0.472370099128661,0,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.43338,-1.09,0.35,1441,0.937,"pentostatin",0.455931955649724,0.0282604091122217,FALSE
+"H520","Pearson.est","serotonin receptor agonist",-0.70693,-1.83,0.0154,1246,0.135,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",1.81247927916354,0.869666231504994,TRUE
+"H520","Pearson.est","serotonin receptor antagonist",-0.42174,-1.1,0.359,1390,0.967,"lurasidone, aripiprazole",0.444905551421681,0.0145735259169983,FALSE
+"H520","Pearson.est","sodium channel blocker",0.33502,0.868,0.617,453,0.925,"brivaracetam, ajmaline, mepivacaine, butamben, cibenzoline, mexiletine",0.209714835966758,0.0338582672609674,FALSE
+"H520","Pearson.est","src inhibitor",-0.31848,-0.813,0.688,1036,0.994,"bosutinib, PP.1, PP.2, masitinib",0.162411561764489,0.00261361560268669,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",-0.33923,-0.89,0.557,1163,0.969,"sulconazole, posaconazole, ketoconazole",0.254144804826271,0.0136762229492347,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",-0.5623,-1.45,0.105,931,0.621,"repsox, adaprev, SB.431542, D.4476, SB.525334",0.978810700930062,0.20690839982342,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",-0.33218,-0.874,0.593,479,0.904,"ftorafur, doxifluridine, raltitrexed, carmofur, capecitabine, trifluridine",0.226945306635737,0.0438315695246367,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",0.31477,0.816,0.668,564,0.853,"mitoxantrone, doxorubicin, idarubicin, exatecan.mesylate, amsacrine, rubitecan, epirubicin, etoposide, voreloxin, daunorubicin, teniposide, camptothecin, valrubicin, genz.644282, licochalcone.a",0.175223537524454,0.069050968832477,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",0.29879,0.773,0.705,393,0.789,"mebendazole, epothilone.b, oxibendazole, BNC105, CYT.997, vinorelbine, fenbendazole, verubulin, taltobulin, indibulin",0.151810883008601,0.10292299679058,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",0.25607,0.669,0.848,510,0.875,"dasatinib, AV.412, bafetinib, NVP.TAE226, sorafenib, mubritinib, tyrphostin.A9, vandetanib, tivantinib, apatinib, PP.121, regorafenib, hypericin",0.0716041477432862,0.0579919469776868,FALSE
+"H520","Pearson.est","VEGFR inhibitor",0.19396,0.516,0.975,118,0.972,"BMS.690514, XL.647, OSI.930, SAR131675",0.0109953843014632,0.0123337350737254,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",0.5113,1.31,0.173,338,0.939,"ercalcitriol, calcitriol, maxacalcitol",0.761953896871205,0.0273344077338891,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",0.4747,1.21,0.243,371,0.981,"CUDC.101, ARRY.334543, BMS.690514, tyrphostin.AG.1478, erlotinib, XL.647, canertinib, WZ.3146, brigatinib, AST.1306, BIBU.1361, gefitinib, PD.168393, icotinib, lapatinib, afatinib, osimertinib, rociletinib, pelitinib, BIBX.1382, AZD8931",0.614393726401688,0.0083309926200515,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",0.36733,0.926,0.519,185,0.874,"dasatinib, metatinib, bafetinib",0.284832642151542,0.058488567365597,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",0.27619,0.706,0.796,498,0.873,"xanomeline, oxiracetam, tremorine",0.0990869322623309,0.0589857562944303,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.75094,-1.99,0.00233,1279,0.118,"dicycloverine, methscopolamine, iododexetimide",2.63264407897398,0.928117992693875,TRUE
+"HCC15","Pearson.est","adenosine receptor antagonist",0.4539,1.16,0.271,111,0.966,"theophylline, PSB.1115",0.567030709125594,0.0150228735845067,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",-0.37441,-0.992,0.426,1230,0.943,"ritodrine, methyldopa, norepinephrine, isoetharine",0.370590400897281,0.0254883072626717,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",0.36834,0.93,0.531,170,0.9,"practolol, idazoxan, propranolol, vincamine",0.274905478918531,0.0457574905606751,FALSE
+"HCC15","Pearson.est","AKT inhibitor",0.38861,0.992,0.446,446,0.956,"MK.2206, triciribine, palomid.529, AT7867, ONC201",0.350665141287858,0.0195421077238999,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.24648,-0.634,0.881,1193,0.966,"alectinib, CEP.37440, DMH1",0.0550240915879521,0.0150228735845067,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.72362,-1.96,0.0121,1184,0.0767,"flutamide, nilutamide, enzalutamide, cyproterone.acetate",1.91721462968355,1.11520463605102,TRUE
+"HCC15","Pearson.est","antioxidant",-0.57035,-1.49,0.0938,1132,0.466,"benfotiamine, trolox",1.02779716162094,0.33161408331,FALSE
+"HCC15","Pearson.est","AP inhibitor",0.62917,1.57,0.0485,82,0.617,"birinapant, GDC.0152",1.31425826139774,0.209714835966758,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",0.39911,1.02,0.417,279,0.935,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin....",0.379863945026242,0.0291883891274822,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",0.40262,1.03,0.41,421,0.959,"alisertib, MK.8745, MK.5108, barasertib.HQPA, ENMD.2076, barasertib, ZM.447439, PF.03814735, danusertib, CCT137690, SNS.314",0.387216143280265,0.0181813928293364,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.30022,0.744,0.777,161,0.912,"tedizolid, azithromycin",0.109578981199086,0.0400051616715838,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.32057,0.81,0.665,434,0.884,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.177178354696895,0.0535477349869269,FALSE
+"HCC15","Pearson.est","BCL inhibitor",-0.35061,-0.95,0.468,1382,0.856,"gossypol, ABT.737",0.329754146925876,0.0675262353228468,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",0.41978,1.07,0.346,185,1,"dasatinib, metatinib, bafetinib",0.460923901207223,0,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.41034,1.04,0.377,146,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.423658649794207,0,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",-0.382,-0.998,0.461,1149,1,"I.BET151, PFI.1",0.336299074610352,0,FALSE
+"HCC15","Pearson.est","calcium channel blocker",-0.3376,-0.897,0.536,1244,0.896,"efonidipine.monoethanolate, SR.33805, mibefradil",0.27083521030723,0.0476919903378748,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.31191,0.812,0.701,470,0.908,"UNBS.5162, MK.0812, ZK811752, RS.504393",0.154281982033341,0.0419141514789149,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.18167,0.459,0.995,475,0.989,"alvocidib, NU6027, kenpaullone, P276.00, AT.7519, aminopurvalanol.a, CR8..R., dinaciclib",0.00217691925427455,0.0048037084028206,FALSE
+"HCC15","Pearson.est","CHK inhibitor",-0.41944,-1.1,0.32,1169,0.983,"AZD7762, SCH.900776, SB.218078",0.494850021680094,0.00744648216786438,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.36877,-0.976,0.453,1212,0.928,"acetylsalicylsalicylic.acid, FR.122047, piroxicam, AM.404, tryptanthrin, naproxen",0.343901797987168,0.0324520237811379,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",0.55354,1.39,0.117,243,0.803,"PF.4981517, morin, eplerenone",0.931814138253838,0.095284454721319,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",-0.25436,-0.679,0.845,1150,0.938,"streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.0731432910503077,0.0277971616209356,FALSE
+"HCC15","Pearson.est","DNA inhibitor",-0.23693,-0.627,0.891,1344,0.948,"pibenzimol, nithiamide",0.0501222959631252,0.0231916626619338,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.69931,1.76,0.017,357,0.742,"azacitidine, SGI.1027, decitabine, fdcyd",1.76955107862173,0.129596094720973,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.46272,1.16,0.282,212,0.966,"foscarnet, cephalomannine, idoxuridine, cidofovir",0.549750891680639,0.0150228735845067,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",-0.35604,-0.929,0.5,1415,0.864,"altretamine, enocitabine",0.301029995663981,0.0634862575211067,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",-0.3643,-0.959,0.486,1029,0.877,"nemonapride, clebopride, mesoridazine, ziprasidone, paliperidone, remoxipride, amisulpride, lurasidone",0.313363730737707,0.0570004066339595,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.29956,-0.801,0.704,1268,0.889,"estrone, erteberel",0.152427340857888,0.0510982390297863,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",-0.79436,-2.06,0.00483,1292,0.13,"danazol, raloxifene, fulvestrant, tamoxifen",2.31605286924849,0.886056647693163,TRUE
+"HCC15","Pearson.est","FGFR inhibitor",-0.31224,-0.832,0.636,449,0.925,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, nintedanib, MK.2461, lucitanib, lenvatinib",0.196542884351586,0.0338582672609674,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",-0.31852,-0.846,0.62,1151,0.932,"KW.2449, pacritinib, TG.101348, quizartinib, TG.02, lestaurtinib, sunitinib",0.207608310501746,0.0305840876460186,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.40605,-1.06,0.368,1017,1,"flumethasone, halcinonide, triamcinolone, desonide, rimexolone, prednisolone, triamcinolone.acetonide, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, piretanide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.434152181326482,0,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",0.31265,0.789,0.703,256,0.867,"ACDPP, tiletamine, kynurenic.acid",0.153044674980176,0.0619809025237897,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.38542,0.975,0.478,23,0.951,"CHIR.99021",0.320572103387881,0.0218194830625861,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",-0.50199,-1.32,0.18,1353,0.737,"GW.441756, lestaurtinib",0.744727494896694,0.132532512140949,FALSE
+"HCC15","Pearson.est","HCV inhibitor",0.35214,0.905,0.568,64,0.884,"daclatasvir",0.245651664288981,0.0535477349869269,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.51723,1.31,0.164,448,0.852,"chidamide, nexturastat.a, panobinostat, belinostat, SB.939, NSC.3852, scriptaid, entinostat, M.344, ACY.1215, resminostat, givinostat, trichostatin.a, mocetinostat, dacinostat, romidepsin",0.785156151952302,0.0695604052332999,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",-0.20707,-0.558,0.945,963,0.977,"lafutidine, ICI.162846, tiotidine, cyproheptadine, terfenadine, ebastine, ranitidine, BF2.649, epinastine",0.0245681914907371,0.0101054362812269,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",0.37717,0.944,0.519,211,0.941,"atorvastatin, simvastatin",0.284832642151542,0.0264103765727431,FALSE
+"HCC15","Pearson.est","HSP inhibitor",0.59866,1.51,0.0688,195,0.665,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, SNX.5422, ganetespib",1.16241156176449,0.177178354696895,FALSE
+"HCC15","Pearson.est","JAK inhibitor",-0.33546,-0.872,0.577,1165,0.914,"pacritinib, TG.101348, CEP.33779, AZD1480, filgotinib, TG.02, lestaurtinib",0.238824186844269,0.0390538042661686,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.28591,0.72,0.825,104,0.878,"midostaurin, OSI.930, dasatinib",0.0835460514500749,0.0565054840938974,FALSE
+"HCC15","Pearson.est","MDM inhibitor",-0.28225,-0.76,0.708,407,0.873,"serdemetan, AMG.232, idasanutlin, nutlin.3, CGM097, RITA",0.149966742310231,0.0589857562944303,FALSE
+"HCC15","Pearson.est","MEK inhibitor",-0.26987,-0.721,0.764,1114,0.906,"PD.318088, nobiletin, refametinib, MEK162, BIX.02188, arctigenin",0.11690664142431,0.0428718023231869,FALSE
+"HCC15","Pearson.est","MET inhibitor",-0.57646,-1.55,0.0798,1135,0.497,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.09799710864927,0.303643611266668,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.40806,1.03,0.42,519,0.959,"estramustine.phosphate, triclabendazole, D.64131, cabazitaxel, podophyllotoxin",0.3767507096021,0.0181813928293364,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",0.64849,1.62,0.0462,393,0.949,"deforolimus, PI.103, AZD8055, everolimus, PKI.179, NVP.BEZ235, temsirolimus, LY3023414, torin.1, torin.2, MLN0128, AZD2014, PP242, GDC.0980, WYE.125132, sirolimus, palomid.529, voxtalisib, PF.04691502, SB.2343",1.33535802444387,0.0227337875727074,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",-0.37119,-0.972,0.453,1046,0.891,"IKK.2.inhibitor.V, curcumin, tyloxapol, Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.343901797987168,0.0501222959631252,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",-0.40723,-1.1,0.328,1285,0.983,"ADL5859, salvinorin.a",0.484126156288321,0.00744648216786438,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",-0.188,-0.508,0.983,898,0.978,"SB.242235, talmapimod, CMPD.1, TAK.715, skepinone.l",0.00744648216786438,0.00966114521239857,FALSE
+"HCC15","Pearson.est","PARP inhibitor",-0.57564,-1.52,0.0745,987,0.476,"olaparib, niraparib, AZD2461, AG.14361, talazoparib",1.12784372725171,0.322393047279507,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.29684,-0.792,0.7,1118,0.874,"imatinib, axitinib, lenvatinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.154901959985743,0.058488567365597,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",-0.29889,-0.785,0.718,1166,0.86,"CID.5458317, menadione, alexidine",0.1438755557577,0.0655015487564323,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",0.28622,0.726,0.808,290,0.892,"papaverine, enoximone, EMD.53998",0.0925886392254138,0.0496351456238769,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",0.35301,0.881,0.597,393,0.87,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, GDC.0980, buparlisib, ZSTK.474, voxtalisib, PF.04691502, SB.2343",0.224025668870631,0.0604807473813815,FALSE
+"HCC15","Pearson.est","PLK inhibitor",0.52789,1.33,0.158,557,0.891,"HMN.214, BI.2536, volasertib",0.801342913045577,0.0501222959631252,FALSE
+"HCC15","Pearson.est","potassium channel blocker",0.64186,1.6,0.0488,370,0.706,"ML133, ibutilide, mepivacaine, oleoylethanolamide, dofetilide",1.31158017799729,0.151195298948196,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.38262,-1.01,0.432,1134,1,"S26948, clofibrate, fenofibrate",0.364516253185088,0,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.74274,-1.98,0.00495,1220,0.0861,"melengestrol.acetate, dienogest, nomegestrol.acetate, norgestrel, danazol, norethindrone.acetate",2.30539480106643,1.06499684854635,TRUE
+"HCC15","Pearson.est","proteasome inhibitor",0.43655,1.1,0.326,455,1,"ONX.0914, MG.132, carfilzomib, delanzomib",0.486782399932061,0,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.23232,0.601,0.919,268,0.965,"clofoctol, cycloheximide, puromycin, thiostrepton",0.0366844886138887,0.0154726866562074,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.33983,0.854,0.624,341,0.889,"AV.412, NVP.TAE226, mubritinib, tyrphostin.A9",0.204815410317576,0.0510982390297863,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.48008,1.21,0.264,364,0.981,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.578396073130169,0.0083309926200515,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",-0.30204,-0.811,0.676,1393,0.933,"sunitinib",0.170053304058364,0.0301183562535,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",0.29303,0.735,0.79,67,0.902,"LE.135",0.102372908709559,0.0447934624580583,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.36771,-0.992,0.4,1441,0.943,"pentostatin",0.397940008672038,0.0254883072626717,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",-0.67185,-1.78,0.0221,1211,0.203,"NAN.190, zolmitriptan, ipsapirone, aripiprazole",1.65560772631489,0.692503962086787,TRUE
+"HCC15","Pearson.est","serotonin receptor antagonist",-0.42442,-1.16,0.249,1390,0.981,"lurasidone, aripiprazole",0.603800652904264,0.0083309926200515,FALSE
+"HCC15","Pearson.est","sodium channel blocker",0.34602,0.881,0.603,463,0.87,"brivaracetam, ajmaline, mepivacaine, butamben, mexiletine, cibenzoline",0.219682687859849,0.0604807473813815,FALSE
+"HCC15","Pearson.est","src inhibitor",-0.31149,-0.81,0.714,1283,0.902,"PP.2, masitinib",0.146301788223826,0.0447934624580583,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",0.37449,0.958,0.496,10,0.948,"chlormidazole",0.304518323509803,0.0231916626619338,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",-0.47619,-1.27,0.198,1048,0.772,"D.4476, SB.431542, adaprev, SB.525334",0.703334809738469,0.112382699664264,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.37034,0.938,0.518,733,0.917,"ftorafur, raltitrexed, doxifluridine, capecitabine, carmofur",0.285670240254767,0.0376306643299789,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",0.32297,0.813,0.703,524,0.934,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin, amsacrine, rubitecan, voreloxin, etoposide, camptothecin, teniposide, daunorubicin, genz.644282, valrubicin",0.153044674980176,0.0296531237699066,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.41064,1.04,0.403,592,1,"epothilone.b, mebendazole, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, plinabulin, parbendazole, KX2.391, dolastatin.10, podophyllotoxin, combretastatin.A.4, paclitaxel, vindesine",0.39469495385889,0,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.31143,0.79,0.708,586,0.891,"dasatinib, AV.412, NVP.TAE226, bafetinib, mubritinib, sorafenib, tyrphostin.A9, tivantinib, aminopurvalanol.a, apatinib, vandetanib, regorafenib, hypericin, GTP.14564, PP.121, tyrphostin.AG.99",0.149966742310231,0.0501222959631252,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.21315,0.54,0.952,129,0.984,"BMS.690514, OSI.930, XL.647, SAR131675",0.0213630516155257,0.00700490156865849,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",0.55408,1.45,0.089,590,0.726,"ercalcitriol, calcitriol, maxacalcitol, tacalcitol, doxercalciferol",1.05060999335509,0.139063379299906,FALSE
+"H460","Pearson.est","EGFR inhibitor",0.3822,0.992,0.443,362,0.889,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, BMS.690514, erlotinib, WZ.3146, XL.647, canertinib, brigatinib, gefitinib, AST.1306, PD.168393, BIBU.1361, icotinib, BIBX.1382, afatinib, pelitinib, lapatinib, AZD8931",0.35359627377693,0.0510982390297863,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",0.27114,0.713,0.786,199,0.938,"dasatinib, metatinib, bafetinib",0.104577453960592,0.0277971616209356,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.24119,-0.625,0.898,1140,0.976,"pilocarpine, nicotine",0.0467236633326956,0.0105501823333082,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",-0.74252,-1.93,0.00575,1329,0.105,"dicycloverine, iododexetimide, methscopolamine",2.24033215531037,0.978810700930062,TRUE
+"H460","Pearson.est","adenosine receptor antagonist",-0.38,-0.969,0.455,1218,0.888,"sulmazole, istradefylline",0.341988603342888,0.051587034221399,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",-0.40242,-1.03,0.414,1041,1,"midodrine, xylazine, oxymetazoline, ritodrine, methyldopa, norepinephrine, isoetharine",0.382999658879101,0,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",0.35206,0.91,0.554,165,0.877,"practolol, propranolol, idazoxan, vincamine",0.25649023527157,0.0570004066339595,FALSE
+"H460","Pearson.est","AKT inhibitor",0.36416,0.961,0.484,493,0.858,"MK.2206, triciribine, ONC201, GSK2110183, palomid.529, AT7867",0.315154638355588,0.0665127121512946,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.38897,-1.01,0.426,1236,0.909,"alectinib, CEP.37440, DMH1",0.370590400897281,0.0414361167780325,FALSE
+"H460","Pearson.est","androgen receptor antagonist",-0.71618,-1.89,0.00816,1044,0.111,"bicalutamide, nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.08830984124614,0.954677021213343,TRUE
+"H460","Pearson.est","antioxidant",-0.62435,-1.61,0.066,1170,0.373,"benfotiamine, trolox",1.18045606445813,0.428291168191312,FALSE
+"H460","Pearson.est","AP inhibitor",0.64981,1.68,0.0414,62,0.656,"birinapant, GDC.0152",1.3829996588791,0.18309616062434,FALSE
+"H460","Pearson.est","ATPase inhibitor",0.41178,1.1,0.321,411,1,"k.strophanthidin, oligomycin.a, ouabain, blebbistatin...., evodiamine, NMS.873, thonzonium",0.493494967595128,0,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",0.23861,0.633,0.888,506,0.945,"MK.5108, barasertib, MK.8745, barasertib.HQPA, alisertib, MLN.8054, ENMD.2076, ZM.447439, PF.03814735, CCT137690",0.051587034221399,0.0245681914907371,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.40025,-1.04,0.393,1332,1,"azalomycin.b, dirithromycin",0.405607449624573,0,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.4241,1.11,0.326,322,1,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.486782399932061,0,FALSE
+"H460","Pearson.est","BCL inhibitor",-0.37063,-0.945,0.489,1401,0.844,"gossypol, ABT.737",0.31069114087638,0.073657553374345,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",0.33168,0.887,0.557,199,0.845,"dasatinib, metatinib, bafetinib",0.254144804826271,0.0731432910503077,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.41886,1.11,0.337,108,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.472370099128661,0,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.58354,-1.52,0.0974,1038,0.394,"bromosporine, JQ1...., I.BET151, PFI.1",1.01144104312138,0.404503778174426,FALSE
+"H460","Pearson.est","calcium channel blocker",-0.36745,-0.949,0.498,1201,0.866,"efonidipine.monoethanolate, SR.33805, mibefradil",0.302770657240282,0.0624821079826534,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.26585,-0.683,0.838,1016,0.972,"navarixin, SB.225002, PF.04136309",0.0767559813697235,0.0123337350737254,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.33156,-0.827,0.654,1078,0.885,"indirubin, AZD5438, abemaciclib, R547, ribociclib, BMS.265246, TG.02, JNJ.7706621",0.184422251675733,0.0530567293021746,FALSE
+"H460","Pearson.est","CHK inhibitor",-0.44864,-1.18,0.254,1034,1,"SCH.900776, AZD7762, SB.218078",0.595166283380062,0,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.3727,-0.943,0.503,1183,0.794,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.298432014944073,0.100179497572904,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",0.57781,1.53,0.0799,252,0.676,"PF.4981517, morin, eplerenone",1.09745322068601,0.170053304058364,FALSE
+"H460","Pearson.est","DNA alkylating agent",-0.34785,-0.897,0.554,990,0.783,"mitomycin.c, carmustine, streptozotocin, melphalan, TH.302, satraplatin, cyclophosphamide, temozolomide",0.25649023527157,0.106238237942057,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.24333,-0.615,0.895,1366,0.965,"nithiamide, pibenzimol",0.048176964684088,0.0154726866562074,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",0.54914,1.41,0.101,554,0.717,"azacitidine, decitabine, SGI.1027, fdcyd",0.995678626217357,0.1444808443322,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",0.35889,0.927,0.526,129,0.883,"foscarnet, cephalomannine, cidofovir",0.279014255846261,0.0540392964224314,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.18947,-0.482,0.983,1420,0.984,"enocitabine",0.00744648216786438,0.00700490156865849,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",-0.36938,-0.94,0.5,1120,0.775,"mesoridazine, ziprasidone, remoxipride, paliperidone, amisulpride, lurasidone",0.301029995663981,0.11069829749369,FALSE
+"H460","Pearson.est","estrogen receptor agonist",-0.39754,-1.02,0.418,1088,1,"ethinyl.estradiol, estrone, erteberel",0.378823718224965,0,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",-0.83998,-2.19,0.00355,1259,0.0213,"danazol, raloxifene, fulvestrant, tamoxifen",2.44977164694491,1.67162039656126,TRUE
+"H460","Pearson.est","FGFR inhibitor",-0.4142,-1.04,0.369,1048,1,"nintedanib, MK.2461, lenvatinib, lucitanib",0.43297363384094,0,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.40395,-1.02,0.417,1172,1,"quizartinib, TG.101348, KW.2449, pacritinib, TG.02, sunitinib, lestaurtinib",0.379863945026242,0,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",-0.39015,-0.986,0.448,867,0.923,"triamcinolone.acetonide, fluorometholone, desonide, clobetasol.propionate, halcinonide, halobetasol.propionate, fludroxycortide, triamcinolone, rimexolone, flumethasone, prednisolone.acetate, prednisolone, beclomethasone.dipropionate, fluocinolone.acetonide, fluticasone.propionate, piretanide, hydrocortisone, flumethasone.pivalate, dexamethasone.acetate",0.348721986001856,0.0347982989740879,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.31904,0.836,0.626,194,0.803,"ACDPP, kynurenic.acid, tiletamine",0.20342566678957,0.095284454721319,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",0.36918,0.965,0.49,42,0.898,"CHIR.99021",0.309803919971486,0.0467236633326956,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.67217,-1.73,0.025,1267,0.231,"GSK1838705A, GW.441756, lestaurtinib",1.60205999132796,0.636388020107856,TRUE
+"H460","Pearson.est","HCV inhibitor",0.38326,1.02,0.418,61,1,"daclatasvir",0.378823718224965,0,FALSE
+"H460","Pearson.est","HDAC inhibitor",0.45107,1.19,0.261,169,1,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, scriptaid, SB.939, ACY.1215",0.583359492661719,0,FALSE
+"H460","Pearson.est","histamine receptor antagonist",-0.31335,-0.802,0.694,987,0.881,"lafutidine, cyproheptadine, ICI.162846, terfenadine, ranitidine, ebastine, tiotidine, epinastine, BF2.649",0.158640529545145,0.0550240915879521,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.38329,1,0.445,206,0.988,"atorvastatin, simvastatin",0.351639989019068,0.00524305541237188,FALSE
+"H460","Pearson.est","HSP inhibitor",0.46014,1.21,0.246,250,1,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, ganetespib, SNX.2112, SNX.5422",0.609064892896621,0,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.39251,-1.03,0.397,1058,1,"AT.9283, CEP.33779, TG.101348, pacritinib, AZD1480, TG.02, filgotinib, lestaurtinib",0.401209493236885,0,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.29241,-0.739,0.774,1288,0.915,"vatalanib, telatinib, sunitinib, masitinib",0.111259039317107,0.0385789059335517,FALSE
+"H460","Pearson.est","MDM inhibitor",0.24272,0.647,0.878,1098,0.959,"serdemetan, idasanutlin, AMG.232, nutlin.3, CGM097, RITA",0.0565054840938974,0.0181813928293364,FALSE
+"H460","Pearson.est","MEK inhibitor",-0.20611,-0.538,0.966,1160,0.982,"MEK162, BIX.02188, nobiletin, arctigenin",0.0150228735845067,0.00788851221305034,FALSE
+"H460","Pearson.est","MET inhibitor",-0.67956,-1.77,0.0186,1131,0.215,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.73048705578208,0.667561540084395,TRUE
+"H460","Pearson.est","microtubule inhibitor",0.33814,0.901,0.556,212,0.855,"estramustine.phosphate, triclabendazole",0.254925208417942,0.0680338852718274,FALSE
+"H460","Pearson.est","mTOR inhibitor",0.69986,1.86,0.0144,186,0.425,"deforolimus, PI.103, torin.1, AZD8055, PKI.179, everolimus, NVP.BEZ235, temsirolimus, PP242, MLN0128, LY3023414, AZD2014, sirolimus, SB.2343, GDC.0980, torin.2",1.84163750790475,0.371611069949688,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",-0.37172,-0.977,0.427,949,0.905,"tyloxapol, curcumin, IKK.2.inhibitor.V, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.369572124974976,0.0433514207947967,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.45726,-1.17,0.285,1272,0.968,"ADL5859, salvinorin.a",0.54515513999149,0.0141246426916063,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",-0.24733,-0.646,0.866,875,0.997,"talmapimod, SB.242235, TAK.715, skepinone.l",0.0624821079826534,0.00130484168834428,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.53099,-1.36,0.145,835,0.612,"E7449, PJ.34, niraparib, AZD2461, olaparib, AG.14361, talazoparib",0.838631997765025,0.213248577854439,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.38374,-0.943,0.496,968,0.794,"motesanib, ponatinib, crenolanib, nintedanib, imatinib, lenvatinib, KI.8751, axitinib, vatalanib, telatinib, sunitinib, CP.673451, masitinib",0.304518323509803,0.100179497572904,FALSE
+"H460","Pearson.est","phosphatase inhibitor",-0.35984,-0.924,0.528,1234,0.78,"menadione, CID.5458317, alexidine",0.277366077466188,0.10790539730952,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",0.20192,0.535,0.969,298,0.963,"papaverine, enoximone, EMD.53998",0.0136762229492347,0.0163737128754655,FALSE
+"H460","Pearson.est","PI3K inhibitor",0.397,1.05,0.394,479,1,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, SB.2343, GDC.0980, ZSTK.474, voxtalisib, PF.04691502, PI3K.IN.2, PI.828, buparlisib, PF.05212384, YM.201636, CUDC.907",0.404503778174426,0,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.30306,-0.767,0.729,844,0.917,"rigosertib, volasertib, GSK461364, NMS.1286937, GW.843682X",0.137272471682025,0.0376306643299789,FALSE
+"H460","Pearson.est","potassium channel blocker",0.58001,1.52,0.0714,459,0.562,"ML133, ibutilide, dofetilide, oleoylethanolamide, mepivacaine",1.14630178822383,0.250263684430939,FALSE
+"H460","Pearson.est","PPAR receptor agonist",-0.32245,-0.817,0.649,1397,0.879,"fenofibrate",0.187755303199631,0.0560111249262281,FALSE
+"H460","Pearson.est","progesterone receptor agonist",-0.61073,-1.55,0.0819,1133,0.384,"norgestrel, dienogest, danazol, melengestrol.acetate, nomegestrol.acetate, norethindrone.acetate",1.08671609823958,0.415668775632469,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.32894,0.844,0.601,205,0.853,"ONX.0914, MG.132",0.22112552799726,0.069050968832477,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",0.25803,0.691,0.843,448,0.936,"clofoctol, cycloheximide, brefeldin.a, azomycin..2.nitroimidazole., thiostrepton, methacycline, chloramphenicol.palmitate, puromycin",0.0741724253752577,0.0287241512618947,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.36757,-0.955,0.496,1371,0.885,"CP.724714, rheochrysidin",0.304518323509803,0.0530567293021746,FALSE
+"H460","Pearson.est","RAF inhibitor",0.40459,1.03,0.378,401,1,"SB.590885, vemurafenib, LGX818, AZ.628, sorafenib, dabrafenib",0.422508200162775,0,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.39823,-1.01,0.445,1375,0.909,"sunitinib",0.351639989019068,0.0414361167780325,FALSE
+"H460","Pearson.est","retinoid receptor agonist",0.38216,0.993,0.451,48,0.943,"LE.135",0.345823458122039,0.0254883072626717,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.3878,-1.01,0.423,1442,0.909,"pentostatin",0.373659632624958,0.0414361167780325,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.77289,-1.96,0.00391,1379,0.122,"ipsapirone, zolmitriptan, aripiprazole",2.40782324260413,0.913640169325252,TRUE
+"H460","Pearson.est","serotonin receptor antagonist",-0.54815,-1.39,0.138,1193,0.6,"ziprasidone, RS.16566, paliperidone, lurasidone, aripiprazole",0.860120913598763,0.221848749616356,FALSE
+"H460","Pearson.est","sodium channel blocker",0.22402,0.587,0.935,502,0.959,"brivaracetam, ajmaline, mexiletine, butamben, mepivacaine, cibenzoline",0.0291883891274822,0.0181813928293364,FALSE
+"H460","Pearson.est","src inhibitor",-0.35508,-0.909,0.54,1051,0.785,"bosutinib, PP.1, PP.2, masitinib",0.267606240177031,0.105130343254747,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",0.32132,0.853,0.633,18,0.872,"chlormidazole",0.198596289982645,0.0594835150674328,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",-0.61698,-1.6,0.0562,957,0.342,"repsox, adaprev, SB.431542, SB.525334, D.4476",1.25026368443094,0.465973893943865,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.2982,-0.763,0.734,430,0.901,"ftorafur, carmofur, raltitrexed, doxifluridine, capecitabine, trifluridine",0.134303940083929,0.045275209020937,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",0.27325,0.713,0.816,272,0.938,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate, epirubicin, amsacrine",0.0883098412461389,0.0277971616209356,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",0.3305,0.841,0.62,370,0.826,"BNC105, mebendazole, epothilone.b, oxibendazole, CYT.997, vinorelbine, fenbendazole, verubulin, taltobulin, indibulin",0.207608310501746,0.0830199526796178,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.25563,-0.645,0.884,1371,0.975,"CP.724714, sunitinib, rheochrysidin",0.0535477349869269,0.0109953843014632,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.21988,-0.564,0.931,1114,0.986,"MK.2461, lenvatinib, KI.8751, axitinib, tivozanib, foretinib, lucitanib, vatalanib, telatinib, sunitinib",0.0310503190186574,0.0061230850587888,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",0.61305,1.61,0.0595,305,0.629,"calcitriol, ercalcitriol, maxacalcitol",1.22548303427145,0.201349354554731,FALSE
+"A549","Pearson.est","EGFR inhibitor",0.46438,1.19,0.259,392,0.868,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, erlotinib, BMS.690514, XL.647, canertinib, WZ.3146, gefitinib, brigatinib, AST.1306, PD.168393, pelitinib, icotinib, BIBU.1361, BIBX.1382, afatinib, AZD8931, lapatinib, dacomitinib, rociletinib, osimertinib, GW.583340",0.586700235918748,0.0614802748235081,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",0.28995,0.745,0.757,264,0.985,"dasatinib, metatinib, bafetinib",0.120904120499927,0.00656376950238827,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",0.20896,0.529,0.959,149,0.967,"xanomeline",0.0181813928293364,0.0145735259169983,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",-0.70032,-1.85,0.012,1295,0.166,"dicycloverine, methscopolamine, iododexetimide",1.92081875395238,0.779891911959945,TRUE
+"A549","Pearson.est","adenosine receptor antagonist",-0.33739,-0.912,0.541,1433,1,"istradefylline",0.266802734893431,0,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",-0.39818,-1.07,0.352,1151,1,"methyldopa, oxymetazoline, ritodrine, norepinephrine, isoetharine",0.453457336521869,0,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",0.35461,0.896,0.567,162,0.943,"practolol, idazoxan, propranolol, vincamine",0.246416941107093,0.0254883072626717,FALSE
+"A549","Pearson.est","AKT inhibitor",0.51689,1.32,0.165,391,0.974,"MK.2206, triciribine, AT7867, palomid.529, ONC201, GSK2110183",0.782516055786094,0.0114410431213845,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33141,-0.863,0.601,1353,0.995,"CEP.37440, DMH1",0.22112552799726,0.00217691925427455,FALSE
+"A549","Pearson.est","androgen receptor antagonist",-0.76175,-2.01,0,1190,0.222,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",Inf,0.653647025549361,TRUE
+"A549","Pearson.est","antioxidant",-0.56775,-1.46,0.108,1159,0.562,"benfotiamine, trolox",0.96657624451305,0.250263684430939,FALSE
+"A549","Pearson.est","AP inhibitor",0.65754,1.7,0.0321,86,1,"birinapant, GDC.0152",1.49349496759513,0,FALSE
+"A549","Pearson.est","ATPase inhibitor",0.41795,1.06,0.391,367,0.945,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.407823242604133,0.0245681914907371,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",0.33189,0.864,0.626,526,0.933,"MK.5108, MK.8745, ENMD.2076, barasertib.HQPA, barasertib, alisertib, PF.03814735, ZM.447439, CCT137690, danusertib, SNS.314, MLN.8054",0.20342566678957,0.0301183562535,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34076,-0.899,0.55,1302,1,"azalomycin.b, dirithromycin",0.259637310505756,0,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.41656,1.07,0.368,331,1,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.434152181326482,0,FALSE
+"A549","Pearson.est","BCL inhibitor",-0.37198,-0.968,0.479,1408,1,"gossypol, ABT.737",0.319664486585437,0,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.36535,0.944,0.54,264,0.966,"dasatinib, metatinib, bafetinib",0.267606240177031,0.0150228735845067,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",0.37616,0.988,0.45,169,0.91,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.346787486224656,0.0409586076789064,FALSE
+"A549","Pearson.est","bromodomain inhibitor",-0.33911,-0.898,0.561,1135,0.995,"I.BET151, PFI.1",0.251037138743839,0.00217691925427455,FALSE
+"A549","Pearson.est","calcium channel blocker",-0.37681,-0.996,0.438,1272,1,"SR.33805, efonidipine.monoethanolate, mibefradil",0.3585258894959,0,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",-0.28661,-0.77,0.718,413,0.866,"UNBS.5162, MK.0812, ZK811752, RS.504393, SB.225002, navarixin, PF.04136309",0.1438755557577,0.0624821079826534,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.23657,-0.626,0.894,1047,0.895,"indirubin, abemaciclib, R547, AZD5438, ribociclib, BMS.265246, TG.02, JNJ.7706621",0.0486624812040823,0.048176964684088,FALSE
+"A549","Pearson.est","CHK inhibitor",-0.41062,-1.08,0.382,1146,1,"SCH.900776, AZD7762, SB.218078",0.417936637088291,0,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",-0.32124,-0.865,0.589,1226,1,"acetylsalicylsalicylic.acid, FR.122047, piroxicam, tryptanthrin, naproxen",0.229884705212898,0,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",0.54156,1.42,0.122,242,0.781,"PF.4981517, morin, eplerenone",0.913640169325252,0.1073489661227,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.29066,-0.747,0.722,994,0.877,"TH.302, streptozotocin, melphalan, satraplatin, carmustine, cyclophosphamide, temozolomide",0.141462802430361,0.0570004066339595,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.27255,-0.727,0.788,1037,0.883,"melphalan, metronidazole, carmustine, busulfan, pibenzimol, nithiamide",0.103473782510445,0.0540392964224314,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.60527,1.57,0.0699,529,0.797,"SGI.1027, azacitidine, decitabine, fdcyd, RG108",1.15552282425432,0.0985416786038876,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",0.41763,1.08,0.363,234,1,"cidofovir, cephalomannine, foscarnet, idoxuridine",0.440093374963888,0,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.32658,-0.86,0.61,1395,0.964,"altretamine, enocitabine",0.214670164989233,0.0159229660971692,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",-0.3761,-0.992,0.456,1148,1,"ziprasidone, mesoridazine, remoxipride, paliperidone, amisulpride, lurasidone",0.341035157335565,0,FALSE
+"A549","Pearson.est","estrogen receptor agonist",-0.31673,-0.826,0.66,1152,0.929,"ethinyl.estradiol, estrone, erteberel",0.180456064458131,0.0319842860063582,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",-0.75142,-1.97,0.00907,1241,0.148,"danazol, raloxifene, fulvestrant, tamoxifen",2.0423927129399,0.829738284605043,TRUE
+"A549","Pearson.est","FGFR inhibitor",-0.24145,-0.629,0.885,1052,0.913,"nintedanib, lenvatinib, MK.2461, lucitanib",0.0530567293021746,0.039529222465701,FALSE
+"A549","Pearson.est","FLT3 inhibitor",-0.31889,-0.85,0.647,1187,0.949,"pacritinib, KW.2449, TG.101348, TG.02, lestaurtinib, sunitinib",0.1890957193313,0.0227337875727074,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.30848,-0.808,0.664,1153,0.904,"beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, fluocinolone.acetonide, flumethasone.pivalate, piretanide, dexamethasone.acetate, hydrocortisone",0.177831920631982,0.0438315695246367,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.29654,0.759,0.736,339,0.993,"ACDPP, tiletamine, kynurenic.acid, CGP.37849",0.133122185662501,0.00305075150461883,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",0.385,0.989,0.45,34,0.956,"CHIR.99021",0.346787486224656,0.0195421077238999,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",-0.51465,-1.35,0.147,964,0.662,"PHA.848125, GSK1904529A, GSK1838705A, GW.441756, lestaurtinib",0.832682665251824,0.1791420105603,FALSE
+"A549","Pearson.est","HCV inhibitor",0.40296,1.03,0.414,78,0.961,"daclatasvir",0.382999658879101,0.0172766123314547,FALSE
+"A549","Pearson.est","HDAC inhibitor",0.46623,1.19,0.259,435,0.868,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, SB.939, ACY.1215, entinostat, scriptaid, resminostat, mocetinostat, M.344, givinostat, romidepsin, trichostatin.a",0.586700235918748,0.0614802748235081,FALSE
+"A549","Pearson.est","histamine receptor antagonist",-0.23882,-0.636,0.892,985,0.929,"cyproheptadine, lafutidine, ICI.162846, ebastine, tiotidine, terfenadine, ranitidine, BF2.649, epinastine",0.0496351456238769,0.0319842860063582,FALSE
+"A549","Pearson.est","HMGCR inhibitor",0.39809,1.01,0.417,200,0.957,"atorvastatin, simvastatin",0.379863945026242,0.0190880622231565,FALSE
+"A549","Pearson.est","HSP inhibitor",0.56363,1.46,0.097,208,0.999,"BIIB021, PU.H71, NMS.E973, SNX.2112, ganetespib, SNX.5422, NVP.AUY922",1.01322826573376,0.000434511774017692,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.35809,-0.954,0.476,1145,0.999,"CEP.33779, pacritinib, TG.101348, AZD1480, filgotinib, TG.02, lestaurtinib",0.322393047279507,0.000434511774017692,FALSE
+"A549","Pearson.est","KIT inhibitor",0.26654,0.675,0.845,101,0.969,"midostaurin, OSI.930, dasatinib",0.0731432910503077,0.0136762229492347,FALSE
+"A549","Pearson.est","MDM inhibitor",0.22053,0.57,0.931,1130,0.967,"serdemetan, idasanutlin, AMG.232, CGM097, nutlin.3, RITA",0.0310503190186574,0.0145735259169983,FALSE
+"A549","Pearson.est","MEK inhibitor",-0.30755,-0.824,0.635,1202,0.903,"nobiletin, refametinib, BIX.02188, MEK162, arctigenin",0.197226274708024,0.0443122496864942,FALSE
+"A549","Pearson.est","MET inhibitor",-0.73841,-1.95,0.00209,1253,0.114,"INC.280, PHA.665752, NVP.BVU972, AMG458",2.67985371388895,0.943095148663527,TRUE
+"A549","Pearson.est","microtubule inhibitor",0.41537,1.06,0.36,409,0.945,"estramustine.phosphate, triclabendazole, podophyllotoxin, cabazitaxel",0.443697499232713,0.0245681914907371,FALSE
+"A549","Pearson.est","mTOR inhibitor",0.64762,1.66,0.0475,319,0.729,"deforolimus, PI.103, AZD8055, PKI.179, torin.1, everolimus, temsirolimus, NVP.BEZ235, LY3023414, MLN0128, PP242, sirolimus, GDC.0980, AZD2014, torin.2, WYE.125132, SB.2343, voxtalisib",1.32330639037513,0.137272471682025,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",-0.42217,-1.1,0.354,1247,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.450996737974212,0,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.43523,-1.13,0.305,1291,1,"ADL5859, salvinorin.a",0.515700160653214,0,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",-0.25993,-0.693,0.814,1158,0.885,"TAK.715, skepinone.l",0.0893755951107988,0.0530567293021746,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.57161,-1.51,0.0837,946,0.534,"PJ.34, olaparib, niraparib, AZD2461, AG.14361, talazoparib",1.07727454200674,0.272458742971444,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30295,-0.796,0.68,1050,0.872,"imatinib, nintedanib, lenvatinib, axitinib, KI.8751, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.167491087293764,0.0594835150674328,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.2668,-0.694,0.824,1424,0.907,"alexidine",0.0840727883028842,0.0423927129399047,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",0.265,0.673,0.853,379,0.919,"papaverine, enoximone, EMD.53998, cilostamide",0.069050968832477,0.0366844886138887,FALSE
+"A549","Pearson.est","PI3K inhibitor",0.35748,0.91,0.553,441,0.997,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, SB.2343, voxtalisib, ZSTK.474, PF.04691502, buparlisib, PI3K.IN.2, YM.201636",0.257274868695302,0.00130484168834428,FALSE
+"A549","Pearson.est","PLK inhibitor",0.31783,0.811,0.691,990,0.967,"HMN.214, BI.2536, volasertib, GSK461364, rigosertib, NMS.1286937, GW.843682X",0.160521952625802,0.0145735259169983,FALSE
+"A549","Pearson.est","potassium channel blocker",0.55091,1.42,0.11,476,0.781,"ibutilide, ML133, oleoylethanolamide, mepivacaine, dofetilide",0.958607314841775,0.1073489661227,FALSE
+"A549","Pearson.est","PPAR receptor agonist",-0.32197,-0.834,0.617,1087,0.946,"clofibrate, S26948, fenofibrate",0.209714835966758,0.0241088635982073,FALSE
+"A549","Pearson.est","progesterone receptor agonist",-0.58387,-1.55,0.069,1114,0.53,"norgestrel, dienogest, danazol, melengestrol.acetate, nomegestrol.acetate, norethindrone.acetate",1.16115090926274,0.275724130399211,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.34747,0.886,0.604,209,0.925,"ONX.0914, MG.132",0.218963061378868,0.0338582672609674,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",0.28274,0.73,0.743,445,0.948,"clofoctol, cycloheximide, puromycin, brefeldin.a, thiostrepton, azomycin..2.nitroimidazole., methacycline",0.129011186239425,0.0231916626619338,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",0.26237,0.673,0.866,448,0.919,"AV.412, NVP.TAE226, mubritinib, PP.121, tyrphostin.A9",0.0624821079826534,0.0366844886138887,FALSE
+"A549","Pearson.est","RAF inhibitor",0.44895,1.2,0.241,532,1,"SB.590885, vemurafenib, AZ.628, sorafenib, LGX818, regorafenib, PLX.4720, dabrafenib",0.617982957425132,0,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",-0.38283,-1.05,0.351,1409,1,"sunitinib",0.454692883534176,0,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.31555,0.82,0.684,54,0.986,"LE.135",0.164943898279884,0.0061230850587888,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.38449,-1.01,0.427,1442,1,"pentostatin",0.369572124974976,0,FALSE
+"A549","Pearson.est","serotonin receptor agonist",-0.68983,-1.77,0.0164,1215,0.212,"NAN.190, ipsapirone, zolmitriptan, aripiprazole",1.7851561519523,0.673664139071249,TRUE
+"A549","Pearson.est","serotonin receptor antagonist",-0.41889,-1.1,0.326,1397,1,"lurasidone, aripiprazole",0.486782399932061,0,FALSE
+"A549","Pearson.est","sodium channel blocker",0.30915,0.78,0.699,475,0.99,"brivaracetam, ajmaline, cibenzoline, butamben, mepivacaine, mexiletine",0.155522824254319,0.00436480540245009,FALSE
+"A549","Pearson.est","src inhibitor",-0.2995,-0.8,0.704,1278,0.892,"PP.2, masitinib",0.152427340857888,0.0496351456238769,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",0.35518,0.906,0.554,13,0.964,"chlormidazole",0.25649023527157,0.0159229660971692,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",-0.54013,-1.43,0.119,973,0.557,"repsox, SB.431542, adaprev, D.4476, SB.525334",0.924453038607469,0.254144804826271,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",-0.29057,-0.781,0.702,419,0.872,"ftorafur, doxifluridine, raltitrexed, capecitabine, carmofur, trifluridine",0.153662887870195,0.0594835150674328,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",0.26423,0.691,0.83,142,0.977,"mitoxantrone, idarubicin, exatecan.mesylate, doxorubicin",0.0809219076239261,0.0101054362812269,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",0.49642,1.27,0.208,423,1,"epothilone.b, mebendazole, BNC105, CYT.997, vinorelbine, oxibendazole, taltobulin, verubulin, fenbendazole, dolastatin.10, plinabulin, podophyllotoxin, indibulin, KX2.391, parbendazole, combretastatin.A.4",0.681936665037238,0,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",0.28736,0.73,0.787,459,0.948,"AV.412, dasatinib, NVP.TAE226, bafetinib, sorafenib, tivantinib, mubritinib, GTP.14564, PP.121, vandetanib, tyrphostin.A9, regorafenib",0.104025267640935,0.0231916626619338,FALSE
+"A549","Pearson.est","VEGFR inhibitor",0.22977,0.593,0.939,83,0.975,"BMS.690514, XL.647, OSI.930, SAR131675",0.0273344077338891,0.0109953843014632,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",0.46843,1.19,0.267,564,0.868,"calcitriol, ercalcitriol, maxacalcitol, doxercalciferol, tacalcitol",0.573488738635425,0.0614802748235081,FALSE
+"HCC44","Pearson.est","EGFR inhibitor",0.42234,1.07,0.365,368,1,"CUDC.101, ARRY.334543, BMS.690514, erlotinib, tyrphostin.AG.1478, XL.647, WZ.3146, canertinib, brigatinib, AST.1306, gefitinib, PD.168393, BIBU.1361, icotinib, lapatinib, AZD8931, pelitinib, afatinib, BIBX.1382, osimertinib",0.437707135543525,0,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",0.30255,0.766,0.734,217,0.875,"metatinib, dasatinib, bafetinib",0.134303940083929,0.0579919469776868,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",-0.24002,-0.621,0.894,1135,0.941,"pilocarpine, nicotine",0.0486624812040823,0.0264103765727431,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",-0.7853,-2.06,0.00202,1306,0.0447,"dicycloverine, methscopolamine, iododexetimide",2.69464863055338,1.34969247686806,TRUE
+"HCC44","Pearson.est","adenosine receptor antagonist",0.3631,0.946,0.519,133,0.971,"theophylline, PSB.1115",0.284832642151542,0.0127807700919951,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.40355,-1.04,0.383,1093,0.952,"oxymetazoline, xylazine, methyldopa, ritodrine, norepinephrine, isoetharine",0.416801226031377,0.0213630516155257,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",0.31689,0.826,0.64,211,0.834,"practolol, idazoxan, propranolol, vincamine",0.193820026016113,0.0788339493622613,FALSE
+"HCC44","Pearson.est","AKT inhibitor",0.38514,1.01,0.445,505,0.925,"MK.2206, triciribine, ONC201, AT7867, palomid.529, GSK2110183",0.351639989019068,0.0338582672609674,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.33911,-0.872,0.591,1213,0.942,"alectinib, CEP.37440, DMH1",0.228412519118745,0.0259490972071227,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",-0.75662,-1.96,0.00412,1244,0.0804,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",2.38510278396687,1.09474395125155,TRUE
+"HCC44","Pearson.est","antioxidant",-0.67595,-1.78,0.0252,1145,0.205,"benfotiamine, trolox",1.59859945921846,0.688246138944246,TRUE
+"HCC44","Pearson.est","AP inhibitor",0.64671,1.67,0.0402,59,0.482,"birinapant, GDC.0152",1.39577394691553,0.31695296176115,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",0.4248,1.08,0.344,309,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin...., NMS.873",0.46344155742847,0,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",0.2396,0.621,0.877,281,0.926,"MK.5108, MK.8745, barasertib, ENMD.2076, barasertib.HQPA, alisertib",0.0570004066339595,0.0333890133180656,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.32009,-0.805,0.675,1303,0.923,"azalomycin.b, dirithromycin",0.170696227168975,0.0347982989740879,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",0.33904,0.878,0.547,378,0.801,"lomefloxacin, novobiocin, finafloxacin, trovafloxacin",0.262012673666569,0.0963674839157623,FALSE
+"HCC44","Pearson.est","BCL inhibitor",-0.37243,-0.958,0.49,1392,0.827,"gossypol, ABT.737",0.309803919971486,0.0824944904474534,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",0.36223,0.931,0.525,217,0.91,"metatinib, dasatinib, bafetinib",0.279840696594043,0.0409586076789064,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",0.45147,1.2,0.243,92,1,"gamma.aminobutyric.acid, ivermectin, ZK.93423, bentazepam",0.614393726401688,0,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",-0.46293,-1.17,0.275,939,0.89,"JQ1...., bromosporine, I.BET151, PFI.1",0.560667306169737,0.0506099933550872,FALSE
+"HCC44","Pearson.est","calcium channel blocker",-0.29927,-0.76,0.726,1082,0.896,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.139063379299906,0.0476919903378748,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.20333,-0.519,0.968,293,0.971,"ZK811752, UNBS.5162, MK.0812, RS.504393, SB.225002, navarixin, PF.04136309",0.0141246426916063,0.0127807700919951,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.22962,-0.598,0.919,1044,0.941,"indirubin, AZD5438, R547, abemaciclib, ribociclib, JNJ.7706621, TG.02, BMS.265246",0.0366844886138887,0.0264103765727431,FALSE
+"HCC44","Pearson.est","CHK inhibitor",-0.4633,-1.18,0.261,1096,0.928,"SCH.900776, AZD7762, SB.218078",0.583359492661719,0.0324520237811379,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.40278,-1.05,0.368,1222,0.979,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.434152181326482,0.00921730819686218,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",0.5424,1.41,0.133,274,0.777,"PF.4981517, morin, eplerenone",0.876148359032914,0.109578981199086,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",-0.29081,-0.745,0.752,922,0.873,"mitomycin.c, carmustine, TH.302, melphalan, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.123782159408358,0.0589857562944303,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.24104,-0.628,0.882,1354,0.956,"pibenzimol, nithiamide",0.0545314148681803,0.0195421077238999,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",0.68422,1.77,0.019,380,0.796,"azacitidine, SGI.1027, fdcyd, decitabine",1.72124639904717,0.0990869322623309,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",0.35394,0.93,0.501,287,0.833,"foscarnet, cidofovir, cephalomannine, idoxuridine",0.300162274132754,0.0793549985932124,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",-0.30236,-0.782,0.723,1368,0.886,"altretamine, enocitabine",0.140861702705469,0.0525662781129492,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.37702,-0.983,0.455,1034,0.955,"nemonapride, piperacetazine, mesoridazine, ziprasidone, paliperidone, remoxipride, lurasidone, amisulpride",0.341988603342888,0.0199966284162537,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",-0.37549,-0.96,0.499,1143,0.855,"ethinyl.estradiol, estrone, erteberel",0.30189945437661,0.0680338852718274,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",-0.82612,-2.16,0,1275,0.0317,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.49894073778225,TRUE
+"HCC44","Pearson.est","FGFR inhibitor",-0.26592,-0.689,0.829,1013,0.907,"MK.2461, nintedanib, lenvatinib, lucitanib",0.0814454694497265,0.0423927129399047,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.41558,-1.11,0.316,1210,0.99,"pacritinib, quizartinib, TG.101348, KW.2449, TG.02, sunitinib, lestaurtinib",0.500312917381596,0.00436480540245009,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",-0.46204,-1.2,0.263,956,1,"halobetasol.propionate, fludroxycortide, clobetasol.propionate, ciclesonide, triamcinolone.acetonide, desonide, triamcinolone, halcinonide, flumethasone, rimexolone, prednisolone, beclomethasone.dipropionate, prednisolone.acetate, fluticasone.propionate, piretanide, fluocinolone.acetonide, flumethasone.pivalate, dexamethasone.acetate, hydrocortisone",0.580044251510242,0,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",0.31371,0.803,0.697,311,0.843,"ACDPP, kynurenic.acid, tiletamine, CGP.37849",0.156767221901991,0.0741724253752577,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",0.39479,1.01,0.428,34,0.925,"CHIR.99021",0.368556230986828,0.0338582672609674,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.58059,-1.48,0.102,978,0.631,"PHA.848125, GSK1904529A, GSK1838705A, GW.441756, lestaurtinib",0.991399828238082,0.199970640755866,FALSE
+"HCC44","Pearson.est","HCV inhibitor",0.35954,0.93,0.52,68,0.833,"daclatasvir",0.283996656365201,0.0793549985932124,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",0.44767,1.16,0.261,441,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, entinostat, ACY.1215, resminostat, M.344, mocetinostat, romidepsin, givinostat",0.583359492661719,0,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",-0.29298,-0.759,0.74,998,0.875,"lafutidine, cyproheptadine, ICI.162846, ranitidine, tiotidine, terfenadine, ebastine, BF2.649, epinastine",0.130768280269024,0.0579919469776868,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",0.39135,1.01,0.423,212,0.925,"atorvastatin, simvastatin",0.373659632624958,0.0338582672609674,FALSE
+"HCC44","Pearson.est","HSP inhibitor",0.50079,1.32,0.17,233,0.908,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, ganetespib, SNX.5422, SNX.2112",0.769551078621726,0.0419141514789149,FALSE
+"HCC44","Pearson.est","JAK inhibitor",-0.39231,-1.03,0.396,1170,0.884,"CEP.33779, pacritinib, TG.101348, AZD1480, filgotinib, TG.02, lestaurtinib",0.402304814074488,0.0535477349869269,FALSE
+"HCC44","Pearson.est","KIT inhibitor",-0.28597,-0.736,0.785,1100,0.865,"imatinib, KI.8751, lenvatinib, telatinib, vatalanib, sunitinib, masitinib",0.105130343254747,0.0629838925351858,FALSE
+"HCC44","Pearson.est","MDM inhibitor",-0.40792,-1.05,0.377,1081,0.979,"nutlin.3, CGM097, RITA",0.423658649794207,0.00921730819686218,FALSE
+"HCC44","Pearson.est","MEK inhibitor",-0.30314,-0.804,0.716,1204,0.898,"refametinib, BIX.02188, MEK162, nobiletin, arctigenin",0.145086977692144,0.0467236633326956,FALSE
+"HCC44","Pearson.est","MET inhibitor",-0.5702,-1.47,0.0888,1074,0.575,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.0515870342214,0.24033215531037,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",0.40027,1.03,0.42,167,1,"estramustine.phosphate, triclabendazole",0.3767507096021,0,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",0.68369,1.75,0.037,245,0.455,"deforolimus, PI.103, AZD8055, everolimus, temsirolimus, PKI.179, torin.1, NVP.BEZ235, LY3023414, MLN0128, AZD2014, PP242, GDC.0980, torin.2, sirolimus, WYE.125132, SB.2343",1.431798275933,0.341988603342888,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",-0.39656,-1.03,0.397,1006,0.884,"tyloxapol, IKK.2.inhibitor.V, curcumin, bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.401209493236885,0.0535477349869269,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.45038,-1.18,0.273,1288,0.928,"ADL5859, salvinorin.a",0.563837352959244,0.0324520237811379,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",-0.29318,-0.787,0.699,884,0.902,"SB.242235, talmapimod, CMPD.1, TAK.715, skepinone.l",0.155522824254319,0.0447934624580583,FALSE
+"HCC44","Pearson.est","PARP inhibitor",-0.55474,-1.44,0.109,957,0.573,"olaparib, AZD2461, niraparib, AG.14361, talazoparib",0.962573502059376,0.24184537803261,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.3276,-0.84,0.606,1100,0.915,"imatinib, KI.8751, lenvatinib, axitinib, telatinib, vatalanib, CP.673451, sunitinib, masitinib",0.217527375833714,0.0385789059335517,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",-0.37325,-0.974,0.463,1224,0.934,"CID.5458317, menadione, alexidine",0.334419008982047,0.0296531237699066,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",0.26076,0.687,0.827,149,0.906,"papaverine, enoximone",0.0824944904474534,0.0428718023231869,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",0.40198,1.04,0.401,393,1,"PI.103, PKI.179, BGT226, NVP.BEZ235, LY3023414, GDC.0980, SB.2343, voxtalisib, buparlisib, ZSTK.474, PF.04691502, PI3K.IN.2, PI.828",0.396855627379818,0,FALSE
+"HCC44","Pearson.est","PLK inhibitor",0.36849,0.936,0.506,917,0.945,"HMN.214, BI.2536, volasertib, NMS.1286937, rigosertib, GSK461364, GW.843682X",0.295849483160201,0.0245681914907371,FALSE
+"HCC44","Pearson.est","potassium channel blocker",0.59597,1.56,0.0722,410,0.629,"ML133, ibutilide, dofetilide, oleoylethanolamide, mepivacaine",1.14146280243036,0.201349354554731,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",-0.3392,-0.871,0.603,1414,0.913,"fenofibrate",0.219682687859849,0.039529222465701,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",-0.6591,-1.72,0.0322,1176,0.238,"dienogest, norgestrel, danazol, nomegestrol.acetate, melengestrol.acetate, norethindrone.acetate",1.49214412830417,0.623423042943488,TRUE
+"HCC44","Pearson.est","proteasome inhibitor",0.36826,0.951,0.498,453,1,"ONX.0914, MG.132, carfilzomib, delanzomib",0.302770657240282,0,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",0.28748,0.74,0.735,399,0.888,"clofoctol, cycloheximide, brefeldin.a, puromycin, thiostrepton, azomycin..2.nitroimidazole., methacycline",0.133712660915805,0.051587034221399,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",-0.30848,-0.827,0.66,1342,0.91,"CP.724714, rheochrysidin",0.180456064458131,0.0409586076789064,FALSE
+"HCC44","Pearson.est","RAF inhibitor",0.4578,1.18,0.271,363,1,"SB.590885, vemurafenib, sorafenib, LGX818, dabrafenib, AZ.628",0.567030709125594,0,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.34416,-0.91,0.559,1376,0.894,"sunitinib",0.252588192113577,0.0486624812040823,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",0.35099,0.922,0.529,52,0.815,"LE.135",0.276544327964814,0.0888423912600234,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.3821,-0.969,0.483,1442,0.904,"pentostatin",0.316052869248488,0.0438315695246367,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.68095,-1.81,0.0261,1333,0.208,"ipsapirone, zolmitriptan, aripiprazole",1.58335949266172,0.681936665037238,TRUE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.40062,-1.07,0.353,1123,1,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.452225294612177,0,FALSE
+"HCC44","Pearson.est","sodium channel blocker",0.34717,0.876,0.566,420,0.775,"brivaracetam, ajmaline, mexiletine, cibenzoline, mepivacaine, butamben",0.247183568811729,0.11069829749369,FALSE
+"HCC44","Pearson.est","src inhibitor",-0.37562,-0.968,0.472,1058,0.871,"PP.1, bosutinib, PP.2, masitinib",0.326058001365912,0.0599818449923368,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",0.35361,0.903,0.567,11,0.785,"chlormidazole",0.246416941107093,0.105130343254747,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.50895,-1.34,0.175,927,0.736,"repsox, adaprev, SB.431542, SB.525334, D.4476",0.756961951313706,0.133122185662501,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.32386,-0.848,0.615,467,0.929,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.211124884224583,0.0319842860063582,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",0.2717,0.708,0.8,147,0.906,"mitoxantrone, doxorubicin, idarubicin, exatecan.mesylate",0.0969100130080564,0.0428718023231869,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",0.34717,0.903,0.537,532,0.785,"mebendazole, epothilone.b, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, taltobulin, verubulin, indibulin, dolastatin.10, plinabulin, podophyllotoxin, parbendazole, KX2.391",0.270025714300444,0.105130343254747,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",0.25685,0.669,0.846,542,0.901,"dasatinib, AV.412, NVP.TAE226, bafetinib, mubritinib, sorafenib, tivantinib, vandetanib, GTP.14564, tyrphostin.A9, apatinib, PP.121, regorafenib, aminopurvalanol.a",0.0726296369609765,0.045275209020937,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",0.18234,0.473,0.986,142,0.987,"BMS.690514, OSI.930, XL.647, SAR131675",0.0061230850587888,0.00568284733036327,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",0.59031,1.53,0.0639,251,0.573,"calcitriol, ercalcitriol, maxacalcitol",1.1944991418416,0.24184537803261,FALSE
+"H1703","Pearson.est","EGFR inhibitor",0.3917,1.01,0.442,350,0.905,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, BMS.690514, erlotinib, XL.647, WZ.3146, canertinib, brigatinib, AST.1306, gefitinib, BIBU.1361, icotinib, PD.168393, afatinib, BIBX.1382, AZD8931, pelitinib",0.354577730650908,0.0433514207947967,FALSE
+"H1703","Pearson.est","Abl kinase inhibitor",0.35264,0.914,0.545,208,0.898,"dasatinib, metatinib, bafetinib",0.263603497723358,0.0467236633326956,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",0.26271,0.67,0.836,125,0.9,"xanomeline",0.0777937225609836,0.0457574905606751,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.75347,-1.95,0.00628,1306,0.149,"dicycloverine, methscopolamine, iododexetimide",2.2020403562628,0.826813731587726,TRUE
+"H1703","Pearson.est","adenosine receptor antagonist",-0.34203,-0.912,0.52,1432,0.865,"istradefylline",0.283996656365201,0.0629838925351858,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",-0.37381,-0.961,0.461,1110,0.936,"xylazine, oxymetazoline, methyldopa, ritodrine, norepinephrine, isoetharine",0.336299074610352,0.0287241512618947,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",0.32906,0.841,0.631,106,0.836,"practolol, propranolol, idazoxan",0.199970640755866,0.0777937225609836,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.43614,1.12,0.319,465,1,"MK.2206, triciribine, ONC201, palomid.529, AT7867, GSK2110183",0.496209316942819,0,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.35278,-0.927,0.514,1208,0.899,"alectinib, CEP.37440, DMH1",0.289036881004724,0.0462403082667712,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",-0.72989,-1.9,0.011,1173,0.15,"nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.95860731484178,0.823908740944319,TRUE
+"H1703","Pearson.est","antioxidant",-0.67218,-1.7,0.031,1154,0.266,"benfotiamine, trolox",1.50863830616573,0.575118363368933,FALSE
+"H1703","Pearson.est","AP inhibitor",0.64571,1.61,0.043,34,0.633,"birinapant, GDC.0152",1.36653154442041,0.198596289982645,FALSE
+"H1703","Pearson.est","ATPase inhibitor",0.42606,1.08,0.332,361,0.798,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, NMS.873, blebbistatin....",0.478861916295964,0.0979971086492706,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",0.3383,0.858,0.614,495,0.867,"MK.5108, barasertib.HQPA, barasertib, MK.8745, ENMD.2076, alisertib, PF.03814735, ZM.447439, CCT137690, MLN.8054, SNS.314, danusertib",0.211831628858832,0.0619809025237897,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.36326,-0.952,0.499,1339,0.916,"azalomycin.b, dirithromycin",0.30189945437661,0.0381045263321496,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",0.43388,1.11,0.356,355,1,"lomefloxacin, finafloxacin, novobiocin, trovafloxacin",0.448550002027125,0,FALSE
+"H1703","Pearson.est","BCL inhibitor",-0.38067,-0.979,0.469,1414,1,"gossypol, ABT.737",0.328827157284917,0,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.41345,1.08,0.327,208,0.798,"dasatinib, metatinib, bafetinib",0.485452247339714,0.0979971086492706,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.45108,1.17,0.28,110,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.552841968657781,0,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",-0.40416,-1.07,0.374,1181,1,"I.BET151, PFI.1",0.42712839779952,0,FALSE
+"H1703","Pearson.est","calcium channel blocker",-0.34271,-0.897,0.568,1098,0.867,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.245651664288981,0.0619809025237897,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.23942,-0.634,0.893,345,0.91,"ZK811752, UNBS.5162, RS.504393, MK.0812, SB.225002, navarixin, PF.04136309",0.0491485411114536,0.0409586076789064,FALSE
+"H1703","Pearson.est","CDK inhibitor",-0.24911,-0.665,0.859,1024,0.919,"AZD5438, R547, abemaciclib, indirubin, ribociclib, JNJ.7706621, TG.02, BMS.265246",0.0660068361687577,0.0366844886138887,FALSE
+"H1703","Pearson.est","CHK inhibitor",-0.42128,-1.11,0.309,1146,1,"SCH.900776, AZD7762, SB.218078",0.510041520575165,0,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",-0.41517,-1.09,0.331,1260,1,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.480172006224281,0,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",0.58615,1.48,0.0987,256,0.7,"PF.4981517, morin, eplerenone",1.00568284733036,0.154901959985743,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.36099,-0.928,0.511,969,0.933,"mitomycin.c, TH.302, streptozotocin, carmustine, melphalan, satraplatin, cyclophosphamide, temozolomide",0.291579099865287,0.0301183562535,FALSE
+"H1703","Pearson.est","DNA inhibitor",-0.2611,-0.676,0.849,1108,0.975,"carmustine, busulfan, melphalan, pibenzimol, nithiamide",0.0710923097560473,0.0109953843014632,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",0.63296,1.64,0.0398,469,0.806,"azacitidine, SGI.1027, fdcyd, decitabine",1.40011692792631,0.0936649581949093,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",0.41664,1.08,0.366,261,0.798,"foscarnet, cidofovir, cephalomannine, idoxuridine",0.436518914605589,0.0979971086492706,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.2624,-0.674,0.819,1322,0.953,"altretamine, enocitabine",0.0867160982395816,0.0209070993616736,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",-0.39495,-1.01,0.436,1178,1,"mesoridazine, remoxipride, ziprasidone, paliperidone, lurasidone, amisulpride",0.360513510731414,0,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",-0.28868,-0.765,0.73,1237,0.97,"estrone, erteberel",0.136677139879544,0.0132282657337552,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",-0.82762,-2.22,0,1313,0.0128,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.89279003035213,TRUE
+"H1703","Pearson.est","FGFR inhibitor",-0.25452,-0.672,0.852,366,0.932,"orantinib, regorafenib, erdafitinib, AZD4547, PD.173074, dovitinib, MK.2461, lenvatinib, nintedanib, lucitanib",0.0695604052332999,0.0305840876460186,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",-0.37732,-1,0.416,1175,1,"KW.2449, TG.101348, quizartinib, pacritinib, TG.02, lestaurtinib, sunitinib",0.380906669373257,0,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",-0.40188,-1.04,0.398,976,1,"prednisolone, clobetasol.propionate, desonide, fludroxycortide, halcinonide, triamcinolone.acetonide, triamcinolone, rimexolone, flumethasone, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, piretanide, fluocinolone.acetonide, dexamethasone.acetate, flumethasone.pivalate, hydrocortisone",0.400116927926312,0,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.32877,0.844,0.658,199,0.86,"ACDPP, tiletamine, kynurenic.acid",0.181774106386044,0.0655015487564323,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.38239,0.977,0.481,47,0.888,"CHIR.99021",0.317854923626168,0.051587034221399,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",-0.57265,-1.46,0.0921,1056,0.471,"GSK1904529A, GSK1838705A, GW.441756, lestaurtinib",1.03574036980315,0.326979092871104,FALSE
+"H1703","Pearson.est","HCV inhibitor",0.41707,1.08,0.35,50,0.798,"daclatasvir",0.455931955649724,0.0979971086492706,FALSE
+"H1703","Pearson.est","HDAC inhibitor",0.43226,1.14,0.284,459,1,"nexturastat.a, chidamide, panobinostat, belinostat, NSC.3852, SB.939, scriptaid, ACY.1215, entinostat, M.344, resminostat, mocetinostat, romidepsin, givinostat",0.546681659952962,0,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",-0.21803,-0.581,0.947,989,0.934,"ICI.162846, cyproheptadine, terfenadine, ranitidine, tiotidine, ebastine, epinastine, BF2.649",0.0236500209967266,0.0296531237699066,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",0.35185,0.907,0.551,443,0.875,"atorvastatin, simvastatin, pitavastatin",0.258848401148215,0.0579919469776868,FALSE
+"H1703","Pearson.est","HSP inhibitor",0.50593,1.29,0.187,249,1,"BIIB021, NMS.E973, PU.H71, NVP.AUY922, SNX.2112, SNX.5422, ganetespib",0.728158393463501,0,FALSE
+"H1703","Pearson.est","JAK inhibitor",-0.35336,-0.918,0.555,1126,0.885,"CEP.33779, TG.101348, pacritinib, AZD1480, filgotinib, TG.02, lestaurtinib",0.255707016877324,0.0530567293021746,FALSE
+"H1703","Pearson.est","KIT inhibitor",0.29986,0.758,0.757,66,0.915,"midostaurin, OSI.930, dasatinib",0.120904120499927,0.0385789059335517,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.30836,-0.81,0.681,1032,0.944,"nutlin.3, CGM097, RITA",0.166852888087215,0.025028005701931,FALSE
+"H1703","Pearson.est","MEK inhibitor",-0.33577,-0.865,0.611,1214,0.898,"refametinib, BIX.02188, MEK162, nobiletin, arctigenin",0.213958789757446,0.0467236633326956,FALSE
+"H1703","Pearson.est","MET inhibitor",-0.6719,-1.77,0.0221,1188,0.218,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.65560772631489,0.661543506395395,TRUE
+"H1703","Pearson.est","microtubule inhibitor",0.36874,0.937,0.501,162,0.892,"estramustine.phosphate, triclabendazole",0.300162274132754,0.0496351456238769,FALSE
+"H1703","Pearson.est","mTOR inhibitor",0.68585,1.75,0.0173,243,0.825,"deforolimus, PI.103, AZD8055, PKI.179, everolimus, torin.1, temsirolimus, NVP.BEZ235, LY3023414, PP242, MLN0128, AZD2014, GDC.0980, sirolimus, torin.2, WYE.125132, SB.2343",1.7619538968712,0.0835460514500749,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.4231,-1.12,0.314,1242,1,"bindarit, Ro.106.9920, parthenolide, betulinic.acid",0.503070351926785,0,FALSE
+"H1703","Pearson.est","opioid receptor agonist",-0.45721,-1.21,0.228,1256,0.98,"ADL5859, salvinorin.a",0.642065152999546,0.00877392430750515,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",-0.24359,-0.642,0.879,1311,0.923,"skepinone.l",0.0560111249262281,0.0347982989740879,FALSE
+"H1703","Pearson.est","PARP inhibitor",-0.564,-1.46,0.117,993,0.471,"olaparib, niraparib, AZD2461, AG.14361, talazoparib",0.931814138253838,0.326979092871104,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.30633,-0.807,0.646,1285,0.922,"vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.189767482004916,0.0352690789463706,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.27078,-0.704,0.831,1124,0.988,"menadione, CID.5458317, alexidine",0.080398976215889,0.00524305541237188,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",0.25461,0.661,0.84,305,0.885,"papaverine, enoximone, EMD.53998",0.0757207139381184,0.0530567293021746,FALSE
+"H1703","Pearson.est","PI3K inhibitor",0.36186,0.945,0.526,404,0.917,"PI.103, PKI.179, NVP.BEZ235, LY3023414, BGT226, GDC.0980, SB.2343, ZSTK.474, voxtalisib, buparlisib, PI3K.IN.2, PF.04691502",0.279014255846261,0.0376306643299789,FALSE
+"H1703","Pearson.est","PLK inhibitor",0.34421,0.89,0.57,952,0.872,"HMN.214, BI.2536, volasertib, rigosertib, NMS.1286937, GSK461364, GW.843682X",0.244125144327509,0.0594835150674328,FALSE
+"H1703","Pearson.est","potassium channel blocker",0.59544,1.52,0.0578,483,0.737,"ibutilide, ML133, oleoylethanolamide, dofetilide, mepivacaine",1.23807216157947,0.132532512140949,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",-0.29107,-0.762,0.721,1405,0.949,"fenofibrate",0.142064735280571,0.0227337875727074,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.61981,-1.64,0.0421,1138,0.316,"norgestrel, dienogest, nomegestrol.acetate, melengestrol.acetate, danazol, norethindrone.acetate",1.37571790416433,0.500312917381596,FALSE
+"H1703","Pearson.est","proteasome inhibitor",0.3869,1,0.45,462,0.88,"ONX.0914, MG.132, carfilzomib, delanzomib",0.346787486224656,0.0555173278498314,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",0.26634,0.671,0.879,485,0.925,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, puromycin, azomycin..2.nitroimidazole., methacycline, chloramphenicol.palmitate",0.0560111249262281,0.0338582672609674,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.3228,-0.833,0.627,1366,0.93,"CP.724714, rheochrysidin",0.202732459169284,0.0315170514460649,FALSE
+"H1703","Pearson.est","RAF inhibitor",0.43075,1.11,0.324,489,1,"SB.590885, vemurafenib, sorafenib, AZ.628, dabrafenib, LGX818, PLX.4720, regorafenib",0.489454989793388,0,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",-0.37158,-0.975,0.462,1412,0.988,"sunitinib",0.335358024443874,0.00524305541237188,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",0.27695,0.699,0.829,64,0.972,"LE.135",0.0814454694497265,0.0123337350737254,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.36668,-0.964,0.442,1442,0.971,"pentostatin",0.354577730650908,0.0127807700919951,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",-0.67935,-1.78,0.017,1316,0.254,"zolmitriptan, ipsapirone, aripiprazole",1.76955107862173,0.595166283380062,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",-0.44733,-1.16,0.278,1245,1,"ziprasidone, paliperidone, lurasidone, aripiprazole",0.555955204081924,0,FALSE
+"H1703","Pearson.est","sodium channel blocker",0.32249,0.838,0.646,494,0.813,"brivaracetam, ajmaline, cibenzoline, butamben, mepivacaine, mexiletine",0.189767482004916,0.0899094544059319,FALSE
+"H1703","Pearson.est","src inhibitor",-0.26879,-0.694,0.838,1422,0.976,"masitinib",0.0767559813697235,0.0105501823333082,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",0.34352,0.866,0.615,10,0.885,"chlormidazole",0.211124884224583,0.0530567293021746,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",-0.62423,-1.61,0.0591,1047,0.32,"adaprev, repsox, SB.431542, SB.525334, D.4476",1.22841251911874,0.494850021680094,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",-0.28363,-0.756,0.738,409,0.933,"ftorafur, raltitrexed, doxifluridine, carmofur, capecitabine, trifluridine",0.131943638176958,0.0301183562535,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",0.26859,0.678,0.846,175,0.943,"mitoxantrone, idarubicin, doxorubicin, exatecan.mesylate",0.0726296369609765,0.0254883072626717,FALSE
+"H1703","Pearson.est","tubulin polymerization inhibitor",0.41783,1.09,0.333,286,1,"mebendazole, epothilone.b, BNC105, oxibendazole, vinorelbine, CYT.997, fenbendazole, taltobulin, verubulin, indibulin",0.47755576649368,0,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.26733,0.694,0.819,543,0.95,"dasatinib, AV.412, NVP.TAE226, bafetinib, sorafenib, mubritinib, GTP.14564, tivantinib, apatinib, tyrphostin.A9, vandetanib, regorafenib, PP.121, aminopurvalanol.a",0.0867160982395816,0.0222763947111523,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",0.23303,0.602,0.898,84,0.917,"BMS.690514, OSI.930, XL.647, SAR131675",0.0467236633326956,0.0376306643299789,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.44362,1.14,0.291,440,1,"ercalcitriol, calcitriol, maxacalcitol",0.536107011014093,0,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.37448,0.983,0.446,268,1,"CUDC.101, ARRY.334543, tyrphostin.AG.1478, BMS.690514, erlotinib, WZ.3146, XL.647, canertinib, gefitinib, brigatinib, PD.168393, AST.1306, icotinib, BIBX.1382, BIBU.1361",0.350665141287858,0,FALSE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.23072,-0.597,0.933,1015,0.983,"bosutinib, ponatinib, imatinib, KW.2449, flumatinib",0.0301183562535,0.00744648216786438,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",0.21122,0.541,0.95,150,0.989,"xanomeline",0.0222763947111523,0.0048037084028206,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",-0.74436,-1.91,0.00358,1345,0.17,"dicycloverine, iododexetimide, methscopolamine",2.44611697335613,0.769551078621726,TRUE
+"H1299","Pearson.est","adenosine receptor antagonist",-0.38585,-1,0.419,1208,0.812,"sulmazole, istradefylline",0.377785977033705,0.0904439707588247,FALSE
+"H1299","Pearson.est","adrenergic receptor agonist",-0.39671,-1.02,0.429,1115,0.871,"xylazine, methyldopa, ritodrine, oxymetazoline, norepinephrine, isoetharine",0.367542707815276,0.0599818449923368,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",0.34441,0.886,0.577,184,0.871,"practolol, idazoxan, propranolol, vincamine",0.238824186844269,0.0599818449923368,FALSE
+"H1299","Pearson.est","AKT inhibitor",0.35029,0.908,0.55,488,1,"triciribine, MK.2206, ONC201, GSK2110183, palomid.529, AT7867",0.259637310505756,0,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.38801,-1,0.45,1212,0.812,"alectinib, CEP.37440, DMH1",0.346787486224656,0.0904439707588247,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",-0.71733,-1.87,0.0121,1054,0.16,"bicalutamide, nilutamide, flutamide, enzalutamide, cyproterone.acetate",1.91721462968355,0.795880017344075,TRUE
+"H1299","Pearson.est","antioxidant",-0.64598,-1.73,0.0335,1201,0.259,"benfotiamine, trolox",1.47495519296315,0.586700235918748,FALSE
+"H1299","Pearson.est","AP inhibitor",0.66205,1.7,0.0278,49,0.615,"birinapant, GDC.0152",1.55595520408192,0.211124884224583,FALSE
+"H1299","Pearson.est","ATPase inhibitor",0.4381,1.13,0.294,280,1,"k.strophanthidin, oligomycin.a, evodiamine, ouabain, blebbistatin....",0.531652669587843,0,FALSE
+"H1299","Pearson.est","Aurora kinase inhibitor",0.24364,0.631,0.879,448,0.975,"MK.5108, MK.8745, barasertib, barasertib.HQPA, alisertib, ENMD.2076, MLN.8054, PF.03814735, ZM.447439",0.0560111249262281,0.0109953843014632,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42062,-1.08,0.35,1363,1,"azalomycin.b, dirithromycin",0.455931955649724,0,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.44068,1.15,0.289,182,1,"lomefloxacin, novobiocin, finafloxacin",0.539102157243452,0,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.38806,-1.02,0.405,1403,0.871,"gossypol, ABT.737",0.392544976785331,0.0599818449923368,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",0.26417,0.7,0.825,259,0.951,"dasatinib, metatinib, bafetinib",0.0835460514500749,0.0218194830625861,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.41638,1.07,0.363,124,1,"gamma.aminobutyric.acid, ivermectin, bentazepam, ZK.93423",0.440093374963888,0,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",-0.584,-1.5,0.0883,988,0.418,"JQ1...., bromosporine, I.BET151, PFI.1",1.05403929642243,0.378823718224965,FALSE
+"H1299","Pearson.est","calcium channel blocker",-0.39087,-1.01,0.417,1122,0.856,"pranidipine, efonidipine.monoethanolate, SR.33805, mibefradil",0.379863945026242,0.0675262353228468,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.18752,-0.484,0.988,962,0.984,"navarixin, SB.225002, PF.04136309",0.00524305541237188,0.00700490156865849,FALSE
+"H1299","Pearson.est","CDK inhibitor",-0.32419,-0.823,0.639,1076,0.854,"R547, AZD5438, indirubin, abemaciclib, ribociclib, BMS.265246, JNJ.7706621, TG.02",0.1944991418416,0.068542129310995,FALSE
+"H1299","Pearson.est","CHK inhibitor",-0.41612,-1.07,0.373,1052,0.973,"SCH.900776, AZD7762, SB.218078",0.428291168191312,0.0118871597316481,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",-0.41186,-1.04,0.39,1233,1,"AM.404, acetylsalicylsalicylic.acid, tryptanthrin, FR.122047, piroxicam, naproxen",0.408935392973501,0,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",0.51428,1.34,0.157,282,0.95,"PF.4981517, morin, eplerenone",0.804100347590766,0.0222763947111523,FALSE
+"H1299","Pearson.est","DNA alkylating agent",-0.3376,-0.887,0.558,944,0.767,"mitomycin.c, estramustine, carmustine, TH.302, melphalan, streptozotocin, satraplatin, cyclophosphamide, temozolomide",0.253365801062421,0.115204636051019,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.21955,-0.578,0.942,1357,0.977,"nithiamide, pibenzimol",0.0259490972071227,0.0101054362812269,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",0.61893,1.64,0.0581,507,0.426,"azacitidine, fdcyd, decitabine, SGI.1027",1.23582386760967,0.370590400897281,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",0.37341,0.979,0.457,141,1,"foscarnet, cephalomannine, cidofovir",0.34008379993015,0,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",0.20094,0.518,0.964,229,0.972,"estramustine.phosphate, cisplatin, artemisinin",0.0159229660971692,0.0123337350737254,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",-0.40335,-1.03,0.411,1176,0.93,"mesoridazine, ziprasidone, remoxipride, paliperidone, amisulpride, lurasidone",0.386158178123931,0.0315170514460649,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",-0.40718,-1.03,0.395,1276,0.93,"estrone, erteberel",0.40340290437354,0.0315170514460649,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.84597,-2.16,0,1283,0.0288,"danazol, raloxifene, fulvestrant, tamoxifen",Inf,1.54060751224077,TRUE
+"H1299","Pearson.est","FGFR inhibitor",-0.3918,-0.992,0.459,1019,0.769,"MK.2461, nintedanib, lenvatinib, lucitanib",0.338187314462739,0.114073660198569,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.38371,-0.983,0.473,1151,0.735,"TG.101348, quizartinib, KW.2449, pacritinib, TG.02, sunitinib, lestaurtinib",0.325138859262188,0.133712660915805,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",-0.38006,-0.989,0.458,883,0.749,"clobetasol.propionate, desonide, triamcinolone.acetonide, halobetasol.propionate, fludroxycortide, triamcinolone, halcinonide, flumethasone, prednisolone, rimexolone, prednisolone.acetate, beclomethasone.dipropionate, fluticasone.propionate, fluocinolone.acetonide, piretanide, hydrocortisone, dexamethasone.acetate, flumethasone.pivalate",0.339134521996131,0.125518182300534,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.30866,0.839,0.6,202,0.923,"ACDPP, tiletamine, kynurenic.acid",0.221848749616356,0.0347982989740879,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.34347,0.891,0.579,54,0.943,"CHIR.99021",0.237321436272564,0.0254883072626717,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",-0.64068,-1.67,0.0306,1263,0.259,"GSK1838705A, GW.441756, lestaurtinib",1.51427857351842,0.586700235918748,FALSE
+"H1299","Pearson.est","HCV inhibitor",0.33246,0.888,0.576,83,0.906,"daclatasvir",0.239577516576788,0.0428718023231869,FALSE
+"H1299","Pearson.est","HDAC inhibitor",0.42765,1.13,0.313,388,1,"chidamide, nexturastat.a, panobinostat, belinostat, NSC.3852, scriptaid, SB.939, entinostat, ACY.1215, romidepsin, mocetinostat, resminostat",0.504455662453552,0,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",-0.29824,-0.77,0.706,1031,0.897,"lafutidine, terfenadine, ranitidine, ICI.162846, tiotidine, epinastine, ebastine, BF2.649",0.151195298948196,0.0472075569559079,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",0.40347,1.06,0.394,189,1,"atorvastatin, simvastatin",0.404503778174426,0,FALSE
+"H1299","Pearson.est","HSP inhibitor",0.41032,1.09,0.348,241,1,"BIIB021, NMS.E973, PU.H71, SNX.2112, NVP.AUY922, ganetespib",0.458420756053419,0,FALSE
+"H1299","Pearson.est","JAK inhibitor",-0.38159,-0.979,0.473,1127,0.696,"CEP.33779, TG.101348, pacritinib, AZD1480, filgotinib, TG.02, lestaurtinib",0.325138859262188,0.157390760389438,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.36174,-0.936,0.528,1123,0.747,"KI.8751, imatinib, lenvatinib, vatalanib, telatinib, sunitinib, masitinib",0.277366077466188,0.126679398184601,FALSE
+"H1299","Pearson.est","MDM inhibitor",-0.28277,-0.728,0.797,1057,0.918,"nutlin.3, CGM097, RITA",0.0985416786038876,0.0371573187987575,FALSE
+"H1299","Pearson.est","MEK inhibitor",-0.24697,-0.635,0.904,1202,0.991,"MEK162, BIX.02188, nobiletin, arctigenin",0.0438315695246367,0.00392634551472468,FALSE
+"H1299","Pearson.est","MET inhibitor",-0.66753,-1.71,0.0443,1105,0.243,"INC.280, PHA.665752, NVP.BVU972, AMG458",1.35359627377693,0.614393726401688,TRUE
+"H1299","Pearson.est","microtubule inhibitor",0.36949,0.944,0.49,159,1,"estramustine.phosphate, triclabendazole",0.309803919971486,0,FALSE
+"H1299","Pearson.est","mTOR inhibitor",0.68512,1.79,0.0148,208,0.722,"deforolimus, PI.103, AZD8055, torin.1, PKI.179, everolimus, temsirolimus, NVP.BEZ235, PP242, LY3023414, MLN0128, sirolimus, SB.2343, AZD2014, GDC.0980, torin.2",1.82973828460504,0.141462802430361,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.44207,-1.16,0.269,1264,0.902,"Ro.106.9920, bindarit, parthenolide, betulinic.acid",0.570247719997592,0.0447934624580583,FALSE
+"H1299","Pearson.est","opioid receptor agonist",-0.45925,-1.17,0.277,1267,0.937,"ADL5859, salvinorin.a",0.557520230935551,0.0282604091122217,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",-0.29184,-0.735,0.781,1341,0.93,"skepinone.l",0.1073489661227,0.0315170514460649,FALSE
+"H1299","Pearson.est","PARP inhibitor",-0.55827,-1.47,0.0978,860,0.43,"PJ.34, E7449, olaparib, niraparib, AZD2461, AG.14361, talazoparib",1.0096611452124,0.366531544420413,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.43677,-1.17,0.282,1041,0.937,"nintedanib, ponatinib, crenolanib, KI.8751, imatinib, lenvatinib, axitinib, vatalanib, telatinib, CP.673451, sunitinib, masitinib",0.549750891680639,0.0282604091122217,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.34135,-0.891,0.554,1181,0.781,"menadione, CID.5458317, alexidine",0.25649023527157,0.1073489661227,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",0.2109,0.543,0.964,329,1,"papaverine, enoximone, EMD.53998",0.0159229660971692,0,FALSE
+"H1299","Pearson.est","PI3K inhibitor",0.35513,0.914,0.529,188,1,"PI.103, PKI.179, NVP.BEZ235, BGT226, LY3023414, SB.2343, GDC.0980",0.276544327964814,0,FALSE
+"H1299","Pearson.est","PLK inhibitor",0.34698,0.901,0.569,948,0.967,"HMN.214, BI.2536, volasertib, GSK461364, NMS.1286937, rigosertib, GW.843682X",0.244887733604929,0.0145735259169983,FALSE
+"H1299","Pearson.est","potassium channel blocker",0.56102,1.46,0.103,387,0.749,"ML133, ibutilide, oleoylethanolamide, dofetilide",0.987162775294828,0.125518182300534,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",-0.3185,-0.82,0.66,1398,0.837,"fenofibrate",0.180456064458131,0.07727454200674,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.61916,-1.6,0.0472,1139,0.288,"dienogest, norgestrel, melengestrol.acetate, nomegestrol.acetate, danazol, norethindrone.acetate",1.32605800136591,0.540607512240769,FALSE
+"H1299","Pearson.est","proteasome inhibitor",0.31373,0.811,0.645,220,0.868,"ONX.0914, MG.132",0.190440285364732,0.0614802748235081,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",0.28793,0.742,0.775,441,0.92,"clofoctol, cycloheximide, brefeldin.a, thiostrepton, chloramphenicol.palmitate, methacycline, azomycin..2.nitroimidazole., puromycin",0.11069829749369,0.0362121726544447,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.34845,-0.891,0.564,1375,0.781,"CP.724714, rheochrysidin",0.248720896016658,0.1073489661227,FALSE
+"H1299","Pearson.est","RAF inhibitor",0.31917,0.829,0.64,483,0.904,"SB.590885, vemurafenib, LGX818, sorafenib, AZ.628, dabrafenib",0.193820026016113,0.0438315695246367,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.44339,-1.18,0.264,1393,1,"sunitinib",0.578396073130169,0,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",0.39242,1.04,0.389,48,1,"LE.135",0.410050398674292,0,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.38982,-0.993,0.449,1441,0.795,"pentostatin",0.347753658996677,0.0996328713435297,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",-0.6795,-1.76,0.0153,1344,0.273,"zolmitriptan, ipsapirone, aripiprazole",1.8153085691824,0.563837352959244,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",-0.44142,-1.12,0.317,1164,0.95,"RS.16566, ziprasidone, paliperidone, lurasidone, aripiprazole",0.498940737782249,0.0222763947111523,FALSE
+"H1299","Pearson.est","sodium channel blocker",0.30459,0.822,0.651,343,0.883,"brivaracetam, ajmaline, mexiletine, cibenzoline, butamben",0.186419011431808,0.0540392964224314,FALSE
+"H1299","Pearson.est","src inhibitor",-0.38289,-0.98,0.434,986,0.717,"TG.100572, bosutinib, PP.1, PP.2, masitinib",0.362510270487489,0.1444808443322,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",0.30889,0.8,0.669,23,0.856,"chlormidazole",0.174573882232177,0.0675262353228468,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",-0.64372,-1.66,0.0516,950,0.24,"repsox, adaprev, SB.431542, SB.525334, D.4476",1.28735029837279,0.619788758288394,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",-0.24064,-0.621,0.908,347,0.983,"ftorafur, doxifluridine, raltitrexed, carmofur, capecitabine, trifluridine",0.0419141514789149,0.00744648216786438,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",0.23711,0.635,0.904,187,1,"mitoxantrone, doxorubicin, idarubicin, exatecan.mesylate",0.0438315695246367,0,FALSE
+"H1299","Pearson.est","tubulin polymerization inhibitor",0.36452,0.926,0.519,457,1,"mebendazole, epothilone.b, BNC105, oxibendazole, CYT.997, vinorelbine, fenbendazole, indibulin, verubulin, taltobulin, podophyllotoxin, dolastatin.10, plinabulin",0.284832642151542,0,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",-0.25715,-0.655,0.859,1375,0.991,"CP.724714, sunitinib, rheochrysidin",0.0660068361687577,0.00392634551472468,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.22553,-0.572,0.949,1123,0.96,"KI.8751, lenvatinib, tivozanib, axitinib, foretinib, vatalanib, lucitanib, telatinib, sunitinib",0.0227337875727074,0.0177287669604316,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.66456,1.67,0.0251,246,0.477,"ercalcitriol, calcitriol, maxacalcitol",1.60032627851896,0.321481620959886,FALSE
diff --git a/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren_met_NSCLC/DMEA/DMEA_venn_diagram.pdf
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diff --git a/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_interactive_network.graph.html b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_interactive_network.graph.html
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--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-67dddd8d5adb270a8dbb" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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diff --git a/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv
new file mode 100644
index 0000000..95c2482
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_mean_results.csv
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+"calcium channel blocker",0.669066666666667,0.764335515956429,0.718995992285689,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"protein tyrosine kinase inhibitor",0.6564,0.939729277124914,0.255355467923227,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.492895438084369
+"glucocorticoid receptor agonist",0.6138,1.18168682097125,0.00718308919049664,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0350703766359542
+"ATPase inhibitor",0.577733333333333,1.52591609330576,1.68607565966016e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1650, H2009, H358, H1299, H1703",6.99721398758967e-06
+"BCL inhibitor",0.5258,0.941638935959153,0.485585206952129,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.732792221400485
+"phosphatase inhibitor",0.4896,0.8541608078777,0.840904564162789,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"VEGFR inhibitor",0.412133333333333,0.628340884127928,0.999866235270498,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"PPAR receptor agonist",0.405866666666667,1.26729553812533,0.00455847173507005,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, HCC44",0.0270252252864867
+"serotonin receptor agonist",0.343466666666667,1.38500762590302,0.000588750424142963,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.00640193307478055
+"progesterone receptor agonist",0.339066666666667,1.24491276037816,0.0213166434445007,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.080421882086071
+"benzodiazepine receptor agonist",0.337533333333333,0.927542595607699,0.84214452437271,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"adenosine receptor antagonist",0.322733333333333,1.34172173326805,0.0195544673228818,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1299",0.0772867041809139
+"TGF beta receptor inhibitor",0.3216,1.57032798211984,0.000246250493721987,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,5,"H1975, H2126, A549, HCC44, H460",0.00340646516315415
+"src inhibitor",0.2944,0.962872992663103,0.808986370631176,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"cytochrome P450 inhibitor",0.232,1.15200942456462,0.202547823423821,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.410035837662858
+"acetylcholine receptor agonist",0.209266666666667,1.11106046297263,0.365240456250648,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.644999103591571
+"acetylcholine receptor antagonist",0.2044,1.3579660105151,0.0225333688130711,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1975, HCC44, H460",0.081316070064561
+"adrenergic receptor antagonist",0.202133333333333,0.868700578587407,0.987390223689633,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"PDGFR tyrosine kinase receptor inhibitor",0.193333333333333,0.838695472289016,0.993267927562213,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"bromodomain inhibitor",0.160933333333333,1.2071654796415,0.0930908930682079,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.234137700747311
+"serotonin receptor antagonist",0.110733333333333,1.04811936797476,0.681789041162975,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.992780533623279
+"FLT3 inhibitor",0.0957333333333333,0.803696768214291,0.999505129073447,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"NFkB pathway inhibitor",0.0772666666666667,1.00282247871172,0.813097249720832,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"adrenergic receptor agonist",0.0741333333333333,0.921820471107244,0.970126212481252,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"glutamate receptor antagonist",0.0694666666666667,1.10560028082141,0.4456006573628,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.711986536439988
+"Abl kinase inhibitor",0.0692,0.999047346225393,0.732355202805763,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.99993046379352
+"sodium channel blocker",0.0672,0.775115954459165,0.999890448772568,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"EGFR inhibitor",0.0556666666666666,1.18356390778425,0.148291609268001,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.341894543590114
+"JAK inhibitor",0.0548000000000001,0.813014601872035,0.999292762714507,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"AP inhibitor",0.0368,1.19773620992747,0.134105023630439,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.327374028274306
+"DNA polymerase inhibitor",0.0345333333333333,1.08310294106903,0.460110425658606,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.720550289238949
+"tyrosine kinase inhibitor",0.0322,0.768510079866974,0.99993046379352,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"phosphodiesterase inhibitor",0.0178,1.14608384136091,0.235595172091122,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.465580935322931
+"androgen receptor antagonist",0.0137333333333333,1.10150951404144,0.446063854155173,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.711986536439988
+"KIT inhibitor",-0.00260000000000007,0.91661222522317,0.969847472330129,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"growth factor receptor inhibitor",-0.0062,1.26665917165702,0.0441582097304621,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, H460, H520",0.135363519744558
+"protein synthesis inhibitor",-0.0248,1.00625445518091,0.789642037971312,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"RAF inhibitor",-0.0608666666666667,1.24537543775055,0.0743150575986443,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.198972573570564
+"estrogen receptor antagonist",-0.079,1.1693266682766,0.173377583987051,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.368983063357057
+"CHK inhibitor",-0.0821333333333333,1.2904897667534,0.011720670404108,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.0497579785927863
+"bacterial 50S ribosomal subunit inhibitor",-0.0926666666666667,1.00001640462735,0.835424087205858,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"HCV inhibitor",-0.112533333333333,1.56347515246676,9.13851410698753e-07,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H1703",2.52832223626655e-05
+"microtubule inhibitor",-0.140466666666667,0.964089642147056,0.881634740228835,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"retinoid receptor agonist",-0.140933333333333,1.25581814349205,0.0456648018415377,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.135363519744558
+"dopamine receptor antagonist",-0.162133333333333,0.949306503767481,0.91447544916416,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"proteasome inhibitor",-0.171066666666667,1.3877890158021,0.00010585618528265,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.00175721267569198
+"sterol demethylase inhibitor",-0.176133333333333,1.38625326827731,0.00122163673572184,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H2126, H1299",0.00921780446044664
+"tubulin polymerization inhibitor",-0.2002,1.1915180713215,0.0865375480389498,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.224456765226026
+"RET tyrosine kinase inhibitor",-0.2096,1.16022656654392,0.16357980376848,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.366949289534699
+"histamine receptor antagonist",-0.217266666666667,1.25321777076148,0.0415773699308154,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.132727757856065
+"Bcr.Abl kinase inhibitor",-0.236,1.02768491558176,0.485567344891289,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H1975",0.732792221400485
+"antioxidant",-0.268066666666667,1.34566619012224,0.00186573341751068,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1975, HCC44",0.0129046561377822
+"thymidylate synthase inhibitor",-0.2888,1.56362153806019,6.32468123223936e-08,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1975, H2009, H520",5.24948542275867e-06
+"potassium channel blocker",-0.289666666666667,1.27384831271605,0.0094593736303801,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0436182228511971
+"AKT inhibitor",-0.301733333333333,1.06989995972031,0.419216790362892,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.710101910206531
+"vitamin D receptor agonist",-0.321866666666667,1.28030626172394,0.0119898743597075,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC15",0.0497579785927863
+"mTOR inhibitor",-0.3262,0.969587408569822,0.699832991155403,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"PLK inhibitor",-0.3266,1.72261320590052,2.41831614238838e-06,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,7,"H1650, H1975, H2126, A549, HCC15, HCC44, H520",5.01800599545588e-05
+"glycogen synthase kinase inhibitor",-0.327333333333333,1.19282813195404,0.061643204052963,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.170546197879864
+"ribonucleotide reductase inhibitor",-0.329933333333333,1.0639181269968,0.381561809861436,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.659783962885399
+"PI3K inhibitor",-0.3306,0.729006741101499,0.99907974070906,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"DNA methyltransferase inhibitor",-0.3432,1.34270070061372,0.000877609666336268,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H3255",0.00809351136732336
+"ALK tyrosine kinase receptor inhibitor",-0.3686,0.8960289217271,0.886439888369425,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"CDK inhibitor",-0.3694,0.922757497937567,0.835524921577286,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"opioid receptor agonist",-0.371866666666667,1.05995241582324,0.290289021335075,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.523782364582852
+"DNA inhibitor",-0.386466666666667,1.07833336130124,0.285843393693962,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.523782364582852
+"HSP inhibitor",-0.387533333333333,1.05875667423544,0.278232706670768,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.523782364582852
+"DNA alkylating agent",-0.4264,0.992701782294879,0.512117411498631,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.759031163471185
+"cyclooxygenase inhibitor",-0.4438,0.787414594008228,0.975097561360289,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"Aurora kinase inhibitor",-0.452466666666667,0.964798710810163,0.443235491383775,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.711986536439988
+"HMGCR inhibitor",-0.458066666666667,1.18249243227217,0.0571971980024561,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"H1650, H1975",0.163702325317374
+"CC chemokine receptor antagonist",-0.474533333333333,1.07032157161606,0.182414945640923,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H2126",0.378511012204916
+"p38 MAPK inhibitor",-0.477466666666667,1.24056178902179,0.00598821677746599,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"H520",0.0313670795831991
+"HDAC inhibitor",-0.499666666666667,1.06302712414438,0.139565508463874,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.330969634357187
+"DNA synthesis inhibitor",-0.510666666666667,0.803366280691679,0.930237657776222,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"PARP inhibitor",-0.5204,1.21852016807273,0.00604666594374922,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.0313670795831991
+"estrogen receptor agonist",-0.540133333333333,0.719117799476421,0.977295965776543,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,0,"",0.99993046379352
+"bacterial DNA gyrase inhibitor",-0.6078,0.977415849501707,0.173357113494988,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.368983063357057
+"topoisomerase inhibitor",-0.652066666666667,1.16874563202647,0.0024002044901223,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,1,"HCC44",0.0153243825138578
+"MDM inhibitor",-0.750266666666667,1.2734691912066,0.000617053790340294,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1650, H358, HCC15",0.00640193307478055
+"MEK inhibitor",-0.786733333333333,1.08990192656211,0.0393901766978517,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,3,"H1975, HCC15, HCC44",0.131782638659706
+"MET inhibitor",-0.962,0.942409980543803,0.00106360917134968,"HCC827, HCC95, H1650, H1975, H2009, H2126, H3255, H358, A549, HCC15, HCC44, H1299, H1703, H460, H520",15,2,"HCC44, H1299",0.00882795612220233
diff --git a/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..1ff0005
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_results.csv
@@ -0,0 +1,1246 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"HCC827","Pearson.est","EGFR inhibitor",-0.31927,-0.792,0.727,1125,0.871,"afatinib, BMS.599626, tyrphostin.AG.1478, osimertinib, pelitinib, lapatinib, PD.168393, WZ8040, PD.153035, erlotinib, TAK.285, icotinib, BIBU.1361",0.138465589140962,0.0599818449923368,FALSE
+"HCC827","Pearson.est","Abl kinase inhibitor",-0.31138,-0.773,0.732,1004,0.882,"bosutinib, imatinib, KW.2449, metatinib, tozasertib, bafetinib",0.135488918941608,0.0545314148681803,FALSE
+"HCC827","Pearson.est","acetylcholine receptor agonist",-0.278,-0.69,0.837,1262,0.92,"tremorine",0.07727454200674,0.0362121726544447,FALSE
+"HCC827","Pearson.est","acetylcholine receptor antagonist",0.46678,1.29,0.197,147,1,"methscopolamine, hyoscyamine",0.705533773838407,0,FALSE
+"HCC827","Pearson.est","adenosine receptor antagonist",-0.45639,-1.14,0.276,878,0.735,"MRS.1220, sulmazole, CGS.15943",0.559090917934782,0.133712660915805,FALSE
+"HCC827","Pearson.est","adrenergic receptor agonist",-0.35825,-0.884,0.601,1058,0.957,"A61603, buphenine, oxymetazoline, metaraminol, terbutaline, epinephrine, isoxsuprine",0.22112552799726,0.0190880622231565,FALSE
+"HCC827","Pearson.est","adrenergic receptor antagonist",0.35699,0.95,0.496,111,0.967,"atipamezole, metoprolol, dihydroergocristine, atenolol......",0.304518323509803,0.0145735259169983,FALSE
+"HCC827","Pearson.est","AKT inhibitor",-0.54678,-1.36,0.138,1129,0.56,"GDC.0068, AZD5363, CCT128930, uprosertib, palomid.529, triciribine",0.860120913598763,0.2518119729938,FALSE
+"HCC827","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41805,-1.06,0.392,851,0.785,"alectinib, crizotinib, AZD3463, lorlatinib, NVP.TAE684, GW.788388, CEP.37440",0.406713932979543,0.105130343254747,FALSE
+"HCC827","Pearson.est","androgen receptor antagonist",0.28849,0.795,0.672,1032,1,"RU.58841, enzalutamide, nilutamide, flutamide, bicalutamide, cyproterone.acetate",0.172630726946175,0,FALSE
+"HCC827","Pearson.est","antioxidant",0.38941,1.02,0.397,30,0.871,"trolox",0.401209493236885,0.0599818449923368,FALSE
+"HCC827","Pearson.est","AP inhibitor",-0.46918,-1.15,0.299,958,0.744,"tanshinone.i, GDC.0152, embelin, LCL.161",0.52432881167557,0.128427064454121,FALSE
+"HCC827","Pearson.est","ATPase inhibitor",0.71507,1.94,0.0196,219,0.315,"k.strophanthidin, oligomycin.a, digoxin, blebbistatin...., evodiamine, NMS.873",1.70774392864352,0.501689446210399,FALSE
+"HCC827","Pearson.est","Aurora kinase inhibitor",-0.30475,-0.77,0.75,1056,0.868,"AMG900, hesperadin, KW.2449, alisertib, ZM.447439, tozasertib, PF.03814735, MLN.8054",0.1249387366083,0.0614802748235081,FALSE
+"HCC827","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.39241,1.06,0.355,94,0.924,"josamycin, radezolid",0.449771646944906,0.0343280287798933,FALSE
+"HCC827","Pearson.est","bacterial DNA gyrase inhibitor",-0.29616,-0.75,0.782,1151,0.878,"trovafloxacin, novobiocin",0.106793246940152,0.0565054840938974,FALSE
+"HCC827","Pearson.est","BCL inhibitor",0.44678,1.19,0.244,382,0.996,"ABT.737, gossypol, TW.37, obatoclax, venetoclax",0.612610173661271,0.00174066157630127,FALSE
+"HCC827","Pearson.est","Bcr.Abl kinase inhibitor",-0.34558,-0.867,0.624,1004,0.938,"bosutinib, imatinib, metatinib, tozasertib, bafetinib",0.204815410317576,0.0277971616209356,FALSE
+"HCC827","Pearson.est","benzodiazepine receptor agonist",-0.25005,-0.636,0.876,1160,0.942,"zaleplon, CGS.20625",0.0574958938319193,0.0259490972071227,FALSE
+"HCC827","Pearson.est","bromodomain inhibitor",-0.52024,-1.3,0.166,760,0.618,"I.BET151, bromosporine, OTX015, I.BET.762, JQ1....",0.779891911959945,0.209011524911184,FALSE
+"HCC827","Pearson.est","calcium channel blocker",0.43959,1.18,0.256,80,0.898,"carboxyamidotriazole, efonidipine.monoethanolate",0.59176003468815,0.0467236633326956,FALSE
+"HCC827","Pearson.est","CC chemokine receptor antagonist",-0.33367,-0.835,0.674,1442,0.879,"navarixin",0.17134010346468,0.0560111249262281,FALSE
+"HCC827","Pearson.est","CDK inhibitor",-0.43953,-1.11,0.339,1271,0.736,"kenpaullone, PHA.793887, arcyriaflavin.a, alvocidib, AZD5438",0.469800301796918,0.133122185662501,FALSE
+"HCC827","Pearson.est","CHK inhibitor",-0.56613,-1.42,0.107,1086,0.507,"SCH.900776, LY2603618, LY2606368",0.97061622231479,0.294992040666664,FALSE
+"HCC827","Pearson.est","cyclooxygenase inhibitor",-0.35103,-0.878,0.599,1078,0.942,"acetylsalicylsalicylic.acid, AM.404, FR.122047, aspirin, curcumin, ramifenazone, meloxicam, FK.3311, indoprofen, amfenac",0.222573177610689,0.0259490972071227,FALSE
+"HCC827","Pearson.est","cytochrome P450 inhibitor",-0.33267,-0.849,0.637,1299,0.899,"cobicistat",0.19586056766465,0.0462403082667712,FALSE
+"HCC827","Pearson.est","DNA alkylating agent",-0.46925,-1.16,0.278,1233,0.755,"dianhydrogalactitol, melphalan, streptozotocin, TH.302, dacarbazine",0.555955204081924,0.122053048370812,FALSE
+"HCC827","Pearson.est","DNA inhibitor",-0.2339,-0.577,0.939,1247,0.974,"melphalan, nithiamide, busulfan",0.0273344077338891,0.0114410431213845,FALSE
+"HCC827","Pearson.est","DNA methyltransferase inhibitor",-0.57064,-1.42,0.11,1238,0.507,"decitabine, fdcyd, azacitidine",0.958607314841775,0.294992040666664,FALSE
+"HCC827","Pearson.est","DNA polymerase inhibitor",0.22566,0.611,0.916,82,1,"menadione",0.0381045263321496,0,FALSE
+"HCC827","Pearson.est","DNA synthesis inhibitor",-0.32758,-0.824,0.682,1149,0.858,"CB.10.277, anisomycin, floxuridine, altretamine",0.166215625343521,0.0665127121512946,FALSE
+"HCC827","Pearson.est","dopamine receptor antagonist",-0.3289,-0.829,0.681,1179,0.869,"oxiperomide, acetophenazine, amisulpride, isofloxythepin",0.166852888087215,0.0609802235513335,FALSE
+"HCC827","Pearson.est","estrogen receptor agonist",-0.33715,-0.853,0.623,1302,0.915,"PPT, estradiol",0.20551195334083,0.0385789059335517,FALSE
+"HCC827","Pearson.est","estrogen receptor antagonist",-0.44231,-1.12,0.322,1094,0.746,"toremifene, raloxifene",0.492144128304169,0.127261172527331,FALSE
+"HCC827","Pearson.est","FGFR inhibitor",0.42101,1.16,0.269,234,0.848,"erdafitinib, dovitinib, nintedanib, lenvatinib",0.570247719997592,0.0716041477432862,FALSE
+"HCC827","Pearson.est","FLT3 inhibitor",0.26592,0.716,0.81,263,1,"GTP.14564, TG.101348, dovitinib, ponatinib, ENMD.2076, tyrphostin.AG.1296",0.0915149811213502,0,FALSE
+"HCC827","Pearson.est","glucocorticoid receptor agonist",0.65804,1.77,0.0323,285,0.416,"hydrocortisone, beclomethasone.dipropionate, triamcinolone, halcinonide, dexamethasone.acetate, triamcinolone.acetonide, desonide, deflazacort, flumethasone.pivalate, betamethasone, clobetasol.propionate, ciclesonide, methylprednisolone, rimexolone, fluocinolone.acetonide",1.4907974776689,0.380906669373257,FALSE
+"HCC827","Pearson.est","glutamate receptor antagonist",-0.33719,-0.84,0.655,949,0.893,"ACDPP, LY456236, latrepirdine, SIB.1757, MTPG, diazooxonorleucine",0.183758700008217,0.0491485411114536,FALSE
+"HCC827","Pearson.est","glycogen synthase kinase inhibitor",-0.65554,-1.67,0.0438,1251,0.499,"LY2090314, kenpaullone, GSK.3.inhibitor.IX, AZD2858",1.3585258894959,0.30189945437661,FALSE
+"HCC827","Pearson.est","growth factor receptor inhibitor",0.29285,0.786,0.689,1026,1,"PHA.848125, GSK1904529A, lestaurtinib, danusertib, GW.441756, GSK1838705A, AZD3463",0.161780778092374,0,FALSE
+"HCC827","Pearson.est","HCV inhibitor",-0.70672,-1.75,0.0191,1119,0.438,"PSI.7976, daclatasvir, embelin, Ro.9187",1.71896663275227,0.3585258894959,FALSE
+"HCC827","Pearson.est","HDAC inhibitor",-0.5877,-1.45,0.0946,1168,0.586,"givinostat, nexturastat.a, dacinostat, M.344, entinostat, romidepsin, panobinostat, R306465, PCI.24781, SB.939, tacedinaline, JNJ.26481585",1.02410886359821,0.232102383981909,FALSE
+"HCC827","Pearson.est","histamine receptor antagonist",-0.53699,-1.35,0.142,1145,0.545,"pheniramine, ICI.162846, levocetirizine, tiotidine, ranitidine, terfenadine, tecastemizole, zolantidine, chloropyramine",0.847711655616944,0.263603497723358,FALSE
+"HCC827","Pearson.est","HMGCR inhibitor",-0.42054,-1.05,0.405,1211,0.776,"mevastatin, simvastatin",0.392544976785331,0.110138278741812,FALSE
+"HCC827","Pearson.est","HSP inhibitor",-0.64668,-1.58,0.0505,1220,0.659,"SNX.2112, tanespimycin, SNX.5422, BIIB021, PU.H71, VER.49009, NVP.AUY922, XL888",1.29670862188134,0.18111458540599,FALSE
+"HCC827","Pearson.est","JAK inhibitor",0.2615,0.721,0.797,211,1,"filgotinib, TG.101348, TG.101209, AT.9283, AZ960",0.0985416786038876,0,FALSE
+"HCC827","Pearson.est","KIT inhibitor",-0.28871,-0.725,0.795,1009,0.894,"KI.8751, imatinib, vatalanib, sunitinib, tandutinib, telatinib",0.0996328713435297,0.0486624812040823,FALSE
+"HCC827","Pearson.est","MDM inhibitor",-0.38271,-0.945,0.531,974,0.913,"CGM097, serdemetan, RITA",0.274905478918531,0.039529222465701,FALSE
+"HCC827","Pearson.est","MEK inhibitor",-0.48871,-1.24,0.226,1010,0.611,"AS.703026, arctigenin, AZD8330, cobimetinib, MEK162, PD.184352, trametinib, Ro.4987655, TAK.733, BIX.02188, nobiletin",0.645891560852599,0.213958789757446,FALSE
+"HCC827","Pearson.est","MET inhibitor",-0.57206,-1.42,0.124,1017,0.507,"LY2801653, PF.04217903, AMG458, INC.280",0.906578314837765,0.294992040666664,FALSE
+"HCC827","Pearson.est","microtubule inhibitor",-0.35501,-0.906,0.561,890,0.94,"estramustine.phosphate, D.64131, cabazitaxel, podophyllotoxin",0.251037138743839,0.0268721464003014,FALSE
+"HCC827","Pearson.est","mTOR inhibitor",0.16112,0.433,0.997,299,1,"torin.1, voxtalisib, XL388, PF.04691502, OSI.027, WYE.354, AZD2014, WYE.125132",0.00130484168834428,0,FALSE
+"HCC827","Pearson.est","NFkB pathway inhibitor",0.38871,1.05,0.397,42,0.87,"EVP4593, tyloxapol",0.401209493236885,0.0604807473813815,FALSE
+"HCC827","Pearson.est","opioid receptor agonist",-0.42886,-1.07,0.377,1396,0.794,"salvinorin.a",0.423658649794207,0.100179497572904,FALSE
+"HCC827","Pearson.est","p38 MAPK inhibitor",-0.58324,-1.45,0.0902,1221,0.586,"TAK.715, VX.702, CMPD.1",1.04479346245806,0.232102383981909,FALSE
+"HCC827","Pearson.est","PARP inhibitor",-0.58612,-1.45,0.0946,888,0.586,"E7449, AZD2461, talazoparib, olaparib, PJ.34, niraparib",1.02410886359821,0.232102383981909,FALSE
+"HCC827","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.18419,-0.461,0.988,1009,1,"KI.8751, imatinib, vatalanib, sunitinib, tandutinib, telatinib, trapidil",0.00524305541237188,0,FALSE
+"HCC827","Pearson.est","phosphatase inhibitor",0.35715,0.94,0.525,82,0.926,"GSK2830371, menadione",0.279840696594043,0.0333890133180656,FALSE
+"HCC827","Pearson.est","phosphodiesterase inhibitor",-0.50714,-1.26,0.205,1016,0.6,"cilostamide, papaverine, zardaverine, EMD.53998, GSK256066, YM.976",0.688246138944246,0.221848749616356,FALSE
+"HCC827","Pearson.est","PI3K inhibitor",-0.18036,-0.451,0.997,835,0.991,"CUDC.907, YM.201636, LY3023414, GSK2126458, alpelisib, PKI.179, NVP.BEZ235, taselisib, PF.05212384, LY303511, PIK.75, TG.100713, CH5132799, pilaralisib, PI.103",0.00130484168834428,0.00392634551472468,FALSE
+"HCC827","Pearson.est","PLK inhibitor",0.25121,0.681,0.835,1086,1,"volasertib, NMS.1286937, GW.843682X, rigosertib, HMN.214, GSK461364, BI.2536",0.0783135245163979,0,FALSE
+"HCC827","Pearson.est","potassium channel blocker",-0.59988,-1.51,0.0729,1215,0.646,"oleoylethanolamide, meglitinide",1.13727247168203,0.189767482004916,FALSE
+"HCC827","Pearson.est","PPAR receptor agonist",0.32839,0.902,0.539,251,0.955,"fenofibrate, clofibrate, pterostilbene",0.268411234813261,0.0199966284162537,FALSE
+"HCC827","Pearson.est","progesterone receptor agonist",0.54686,1.45,0.0891,28,1,"norethindrone, tanaproget",1.05012229596313,0,FALSE
+"HCC827","Pearson.est","proteasome inhibitor",-0.7164,-1.83,0.0063,1171,0.429,"carfilzomib, bortezomib, ONX.0914, delanzomib, ixazomib, ixazomib.citrate",2.20065945054642,0.367542707815276,FALSE
+"HCC827","Pearson.est","protein synthesis inhibitor",0.23785,0.651,0.901,235,1,"clofoctol, clindamycin.phosphate, harringtonine, florfenicol",0.045275209020937,0,FALSE
+"HCC827","Pearson.est","protein tyrosine kinase inhibitor",0.41025,1.09,0.349,98,0.935,"mubritinib, PP.121",0.45717457304082,0.0291883891274822,FALSE
+"HCC827","Pearson.est","RAF inhibitor",-0.55186,-1.37,0.136,1226,0.577,"LGX818, CEP.32496, GDC.0879, vemurafenib, dabrafenib",0.866461091629782,0.238824186844269,FALSE
+"HCC827","Pearson.est","RET tyrosine kinase inhibitor",-0.50669,-1.27,0.204,802,0.611,"regorafenib, cabozantinib, vandetanib, sunitinib, apatinib",0.690369832574101,0.213958789757446,FALSE
+"HCC827","Pearson.est","retinoid receptor agonist",-0.32538,-0.82,0.662,1191,0.844,"tamibarotene, AM.580, CD.437",0.1791420105603,0.073657553374345,FALSE
+"HCC827","Pearson.est","ribonucleotide reductase inhibitor",-0.39775,-1.01,0.427,1321,0.831,"fludarabine.phosphate, clofarabine, fludarabine",0.369572124974976,0.080398976215889,FALSE
+"HCC827","Pearson.est","serotonin receptor agonist",0.44602,1.22,0.216,216,1,"NAN.190, zolmitriptan, aripiprazole",0.665546248849069,0,FALSE
+"HCC827","Pearson.est","serotonin receptor antagonist",0.24134,0.652,0.869,216,1,"SB.200646, pirenperone, aripiprazole",0.0609802235513335,0,FALSE
+"HCC827","Pearson.est","sodium channel blocker",0.27448,0.762,0.766,184,1,"cibenzoline, oxcarbazepine, benzethonium",0.115771230367396,0,FALSE
+"HCC827","Pearson.est","src inhibitor",-0.25612,-0.64,0.881,1004,0.956,"bosutinib, saracatinib, KX2.391, PP.2",0.0550240915879521,0.0195421077238999,FALSE
+"HCC827","Pearson.est","sterol demethylase inhibitor",0.46536,1.27,0.217,239,1,"posaconazole, sulconazole, terconazole, chlormidazole",0.66354026615147,0,FALSE
+"HCC827","Pearson.est","TGF beta receptor inhibitor",-0.37028,-0.934,0.524,1107,0.908,"repsox, D.4476, LY2109761",0.280668713016273,0.0419141514789149,FALSE
+"HCC827","Pearson.est","thymidylate synthase inhibitor",-0.61255,-1.51,0.0525,1266,0.646,"raltitrexed, carmofur, doxifluridine",1.27984069659404,0.189767482004916,FALSE
+"HCC827","Pearson.est","topoisomerase inhibitor",-0.50946,-1.27,0.193,1195,0.611,"amsacrine, etoposide, nemorubicin, irinotecan, rubitecan, SN.38, licochalcone.a, camptothecin, exatecan.mesylate, genz.644282",0.714442690992226,0.213958789757446,FALSE
+"HCC827","Pearson.est","tubulin polymerization inhibitor",-0.33859,-0.855,0.623,1039,0.936,"epothilone.d, epothilone.b, plinabulin, mebendazole, fosbretabulin, KX2.391, taltobulin, podophyllotoxin, combretastatin.A.4",0.20551195334083,0.0287241512618947,FALSE
+"HCC827","Pearson.est","tyrosine kinase inhibitor",0.19558,0.524,0.974,98,1,"mubritinib, GTP.14564, PP.121",0.0114410431213845,0,FALSE
+"HCC827","Pearson.est","VEGFR inhibitor",0.13506,0.372,1,385,0.999,"SAR131675, ZM.306416, dovitinib, axitinib, nintedanib, ENMD.2076, lenvatinib, semaxanib, cediranib, linifanib, pazopanib, motesanib",0,0.000434511774017692,FALSE
+"HCC827","Pearson.est","vitamin D receptor agonist",-0.38639,-0.974,0.494,1239,0.879,"calcitriol, ercalcitriol",0.306273051076353,0.0560111249262281,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",-0.15561,-0.382,1,944,1,"neratinib, GW.583340, erlotinib, BIBU.1361, OSI.420, WZ8040, lapatinib, CP.724714, AEE788, TAK.285, BIBX.1382, tyrphostin.AG.1478, BMS.599626",0,0,FALSE
+"HCC95","Pearson.est","Abl kinase inhibitor",0.26229,0.704,0.807,157,0.884,"ZM.306416, flumatinib, ponatinib",0.0931264652779296,0.0535477349869269,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.50752,1.35,0.15,3,0.726,"xanomeline",0.823908740944319,0.139063379299906,FALSE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.37627,-0.94,0.537,822,0.78,"dicycloverine, hyoscyamine, darifenacin, diphemanil",0.270025714300444,0.10790539730952,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",0.39695,1.07,0.36,876,0.849,"MRS.1220, SCH.58261, istradefylline, CGS.15943, PSB.1115, theophylline, sulmazole",0.443697499232713,0.0710923097560473,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",-0.41177,-1.03,0.444,1202,0.831,"methyldopa, buphenine, clenbuterol, terbutaline, metaraminol, epinephrine",0.35261702988538,0.080398976215889,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",0.2759,0.759,0.737,99,0.984,"atipamezole, atenolol...., prazosin",0.132532512140949,0.00700490156865849,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.47841,-1.18,0.272,1237,0.892,"GDC.0068, ONC201, triciribine, uprosertib",0.565431095965801,0.0496351456238769,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.41041,-1.01,0.447,771,0.795,"brigatinib, lorlatinib, DMH1, AZD3463, CEP.37440, crizotinib, GW.788388",0.349692476868064,0.0996328713435297,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",-0.57758,-1.44,0.083,949,0.95,"nilutamide, enzalutamide, cyproterone.acetate, bicalutamide",1.08092190762393,0.0222763947111523,FALSE
+"HCC95","Pearson.est","antioxidant",0.476,1.28,0.196,146,0.649,"trolox, benfotiamine",0.707743928643524,0.187755303199631,FALSE
+"HCC95","Pearson.est","AP inhibitor",0.37948,1.04,0.38,2,0.836,"idronoxil",0.42021640338319,0.0777937225609836,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",0.65199,1.74,0.0211,282,0.807,"k.strophanthidin, blebbistatin...., NMS.873, evodiamine, ouabain, thonzonium, digitoxigenin",1.67571754470231,0.0931264652779296,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",-0.25637,-0.623,0.902,1290,0.984,"hesperadin, MLN.8054, PF.03814735, tozasertib",0.0447934624580583,0.00700490156865849,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.4343,-1.07,0.379,970,0.859,"valnemulin, azalomycin.b, tedizolid, dirithromycin, azithromycin",0.421360790031928,0.0660068361687577,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",-0.37044,-0.93,0.555,1360,0.76,"lomefloxacin, novobiocin",0.255707016877324,0.119186407719209,FALSE
+"HCC95","Pearson.est","BCL inhibitor",0.31602,0.855,0.611,345,0.973,"ABT.737, gossypol, TW.37, navitoclax",0.213958789757446,0.0118871597316481,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.31434,-0.772,0.749,1308,0.89,"imatinib, tozasertib",0.125518182300534,0.0506099933550872,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",-0.30341,-0.752,0.772,965,0.901,"bentazepam, ivermectin, lorazepam, eprinomectin, zaleplon",0.112382699664264,0.045275209020937,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",0.48096,1.32,0.181,316,0.663,"PFI.1, bromosporine, OTX015",0.742321425130815,0.178486471595227,FALSE
+"HCC95","Pearson.est","calcium channel blocker",0.26378,0.734,0.75,279,0.882,"efonidipine.monoethanolate, SR.33805, tetrandrine, carboxyamidotriazole",0.1249387366083,0.0545314148681803,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",-0.56687,-1.39,0.111,1063,0.797,"MK.0812, ZK811752, RS.504393, PF.04136309, navarixin",0.954677021213343,0.0985416786038876,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.32268,-0.802,0.689,996,0.863,"indisulam, BMS.265246, arcyriaflavin.a, JNJ.7706621, BMS.387032, R547, AZD5438, PHA.793887, alvocidib",0.161780778092374,0.0639892042847904,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.56236,-1.39,0.124,914,0.797,"PF.477736, LY2603618, LY2606368, SB.218078, CHIR.124, SCH.900776",0.906578314837765,0.0985416786038876,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",-0.44585,-1.1,0.338,1146,0.89,"phenazone, acetylsalicylsalicylic.acid, indoprofen, FK.3311, ramifenazone, curcumin, aspirin, amfenac, meloxicam",0.471083299722345,0.0506099933550872,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.42249,1.16,0.279,200,0.733,"eplerenone, morin, metyrapone",0.554395796726402,0.134896025358872,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.50732,-1.26,0.215,1124,0.87,"cyclophosphamide, melphalan, carboplatin, dianhydrogalactitol, mitomycin.c, dacarbazine",0.667561540084395,0.0604807473813815,FALSE
+"HCC95","Pearson.est","DNA inhibitor",-0.62148,-1.52,0.0666,1123,0.947,"valrubicin, tirapazamine, melphalan, carboplatin, sangivamycin, nimorazole, busulfan, nithiamide",1.1765257708297,0.0236500209967266,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",-0.55324,-1.41,0.103,1316,0.941,"fdcyd, azacitidine",0.987162775294828,0.0264103765727431,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",-0.31866,-0.803,0.714,1015,0.88,"idoxuridine, famciclovir, trifluridine, foscarnet",0.146301788223826,0.0555173278498314,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",-0.40767,-1.01,0.436,1147,0.795,"CB.10.277, cyclocytidine, enocitabine, mitomycin.c, floxuridine, altretamine",0.360513510731414,0.0996328713435297,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",-0.49299,-1.21,0.266,1070,0.905,"acetophenazine, ziprasidone, lurasidone, domperidone, isofloxythepin, amisulpride, oxiperomide",0.575118363368933,0.0433514207947967,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.42502,-1.05,0.415,1315,0.842,"equol, PPT",0.381951903287907,0.0746879085003505,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",-0.2251,-0.572,0.941,769,1,"tamoxifen, danazol, clomifene, raloxifene",0.0264103765727431,0,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",0.26773,0.746,0.767,1063,0.906,"erdafitinib, PD.173074, nintedanib, orantinib, MK.2461, dovitinib, AZD4547, regorafenib, lucitanib, lenvatinib",0.115204636051019,0.0428718023231869,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",-0.41457,-1.03,0.422,1327,0.831,"sunitinib, tozasertib, pacritinib, tandutinib",0.374687549038326,0.080398976215889,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",0.59776,1.57,0.0742,245,0.869,"deflazacort, prednisolone.hemisuccinate, triamcinolone.acetonide, flumethasone.pivalate, beclomethasone.dipropionate, dexamethasone.acetate, desonide, triamcinolone, betamethasone, ciclesonide, fluocinolone.acetonide, halcinonide, piretanide, rimexolone, hydrocortisone",1.12959609472097,0.0609802235513335,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",-0.36231,-0.897,0.58,1212,0.798,"tiletamine, CPP, latrepirdine, diazooxonorleucine",0.236572006437063,0.0979971086492706,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.24547,0.646,0.844,308,0.917,"indirubin, TWS.119, CHIR.99021",0.073657553374345,0.0376306643299789,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",0.29632,0.786,0.728,1021,0.992,"GSK1904529A, PHA.848125, lestaurtinib, danusertib, AZD3463, GSK1838705A, GW.441756",0.137868620686963,0.00348832784582135,FALSE
+"HCC95","Pearson.est","HCV inhibitor",-0.54442,-1.34,0.149,1109,0.742,"PSI.7976, embelin, Ro.9187, daclatasvir",0.826813731587726,0.129596094720973,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",-0.27388,-0.684,0.835,1000,0.936,"PCI.24781, chidamide, romidepsin, M.344, dacinostat, tacedinaline, SB.939, JNJ.26481585, vorinostat",0.0783135245163979,0.0287241512618947,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",-0.42989,-1.08,0.364,982,0.868,"nizatidine, lafutidine, tecastemizole, levocetirizine, astemizole, tiotidine, terfenadine, chloropyramine, zolantidine",0.438898616350944,0.0614802748235081,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.30652,0.835,0.653,1006,0.954,"lovastatin, atorvastatin, pitavastatin, fluvastatin, simvastatin, mevastatin",0.185086818724926,0.0204516252959049,FALSE
+"HCC95","Pearson.est","HSP inhibitor",-0.19962,-0.491,0.985,766,1,"SNX.2112, BIIB021, XL888, tanespimycin, NVP.AUY922, guanidine, PU.H71, VER.49009",0.00656376950238827,0,FALSE
+"HCC95","Pearson.est","JAK inhibitor",-0.38069,-0.941,0.535,1355,0.798,"LY2784544, atiprimod, tozasertib, pacritinib",0.271646217978772,0.0979971086492706,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.34966,-0.853,0.631,1308,0.855,"imatinib, sunitinib, tandutinib",0.199970640755866,0.0680338852718274,FALSE
+"HCC95","Pearson.est","MDM inhibitor",-0.29094,-0.715,0.819,1048,0.916,"idasanutlin, nutlin.3",0.0867160982395816,0.0381045263321496,FALSE
+"HCC95","Pearson.est","MEK inhibitor",-0.50416,-1.24,0.229,1041,0.87,"arctigenin, TAK.733, PD.198306, nobiletin, Ro.4987655, AS.703026, cobimetinib, MEK162, BIX.02188, PD.98059, trametinib, PD.0325901",0.640164517660112,0.0604807473813815,FALSE
+"HCC95","Pearson.est","MET inhibitor",-0.60191,-1.49,0.0774,903,0.892,"LY2801653, NVP.BVU972, INC.280, PF.04217903, AMG458",1.11125903931711,0.0496351456238769,FALSE
+"HCC95","Pearson.est","microtubule inhibitor",0.28283,0.754,0.741,27,0.94,"cytochalasin.b",0.130181792020672,0.0268721464003014,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.38762,-0.969,0.499,1088,0.831,"NVP.BEZ235, GSK2126458, AZD8055, PP242, GDC.0980, LY303511, sirolimus, ku.0063794, PI.103",0.30189945437661,0.080398976215889,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",-0.38194,-0.943,0.526,1242,0.815,"parthenolide...., betulinic.acid, bortezomib, curcumin",0.279014255846261,0.0888423912600234,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",-0.40155,-1.01,0.438,1189,0.795,"BW.180C, salvinorin.a",0.3585258894959,0.0996328713435297,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",-0.64469,-1.59,0.0487,929,0.848,"CMPD.1, SB.239063, SB.242235, talmapimod, skepinone.l, VX.702, TAK.715",1.31247103878537,0.0716041477432862,FALSE
+"HCC95","Pearson.est","PARP inhibitor",-0.42941,-1.08,0.357,1215,0.868,"PJ.34, niraparib, olaparib",0.447331783887807,0.0614802748235081,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.38538,-0.961,0.502,1308,0.801,"imatinib, sunitinib, trapidil, tandutinib",0.299296282854981,0.0963674839157623,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.55023,1.5,0.108,166,0.743,"GSK2830371, menadione, CID.5458317, bis.maltolato.oxovanadium.IV.",0.96657624451305,0.129011186239425,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.31494,0.855,0.59,8,0.973,"avanafil",0.229147988357856,0.0118871597316481,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.38592,-0.961,0.534,1088,0.801,"NVP.BEZ235, pilaralisib, GSK2126458, PIK.75, alpelisib, taselisib, GDC.0980, LY303511, TG.100713, PI.103, CH5132799",0.272458742971444,0.0963674839157623,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.4512,-1.11,0.346,753,0.903,"HMN.214, NMS.1286937, GW.843682X, GSK461364, BI.2536",0.460923901207223,0.0443122496864942,FALSE
+"HCC95","Pearson.est","potassium channel blocker",-0.55968,-1.38,0.123,1217,0.749,"meglitinide, oleoylethanolamide",0.910094888560602,0.125518182300534,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.3594,0.956,0.478,140,0.954,"pterostilbene, fenofibrate",0.320572103387881,0.0204516252959049,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",0.53604,1.48,0.112,44,0.595,"norethindrone, tanaproget",0.950781977329818,0.22548303427145,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",-0.69492,-1.71,0.0155,1028,0.568,"MG.132, ixazomib.citrate, ONX.0914, delanzomib, carfilzomib, bortezomib, ixazomib",1.80966830182971,0.245651664288981,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",0.22711,0.62,0.892,1123,0.905,"clindamycin.phosphate, clofoctol, methacycline, harringtonine, cycloheximide, azomycin..2.nitroimidazole., chloramphenicol.palmitate, anguidine, florfenicol, mercaptopurine, tedizolid.phosphate, emetine, thiostrepton, puromycin, brefeldin.a, bruceantin, homoharringtonine",0.0496351456238769,0.0433514207947967,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",0.4416,1.22,0.197,42,0.687,"PP.121, mubritinib",0.705533773838407,0.16304326294045,FALSE
+"HCC95","Pearson.est","RAF inhibitor",-0.44802,-1.12,0.323,1075,0.919,"LGX818, SB.590885, CEP.32496, dabrafenib, vemurafenib, AZ.628",0.490797477668897,0.0366844886138887,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.53408,-1.33,0.159,1327,0.714,"sunitinib, apatinib",0.798602875679548,0.146301788223826,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.38123,-0.938,0.52,1066,0.764,"adapalene, bexarotene, tamibarotene, AM.580, CD.437",0.283996656365201,0.11690664142431,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",-0.39381,-0.985,0.471,961,0.823,"cladribine, clofarabine, fludarabine, fludarabine.phosphate",0.326979092871104,0.0846001647877302,FALSE
+"HCC95","Pearson.est","serotonin receptor agonist",-0.33844,-0.828,0.675,814,0.858,"ipsapirone, aripiprazole, zolmitriptan",0.170696227168975,0.0665127121512946,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",-0.47115,-1.18,0.266,985,0.892,"sertindole, aripiprazole, ziprasidone, SB.228357, lurasidone, SB.216641, RS.16566",0.575118363368933,0.0496351456238769,FALSE
+"HCC95","Pearson.est","sodium channel blocker",-0.34142,-0.851,0.645,1149,0.84,"triamterene, brivaracetam, ajmaline, butamben, lappaconite",0.190440285364732,0.0757207139381184,FALSE
+"HCC95","Pearson.est","src inhibitor",0.33204,0.873,0.571,124,1,"ZM.306416, TG.100572, masitinib",0.243363891754152,0,FALSE
+"HCC95","Pearson.est","sterol demethylase inhibitor",-0.46713,-1.15,0.296,1273,0.927,"ketoconazole, lanoconazole",0.528708288941061,0.0329202658555029,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.4514,-1.12,0.345,1103,0.919,"repsox, D.4476, LY2109761",0.462180904926726,0.0366844886138887,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.72545,-1.79,0.0088,1181,0.609,"raltitrexed, trifluridine, carmofur, doxifluridine",2.05551732784983,0.215382707367125,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",-0.42169,-1.05,0.411,859,0.842,"dexrazoxane, etoposide, rubitecan, beta.lapachone, idarubicin, camptothecin, amonafide, valrubicin, SN.38, topotecan, irinotecan, amsacrine, genz.644282, licochalcone.a, exatecan.mesylate",0.386158178123931,0.0746879085003505,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.11291,-0.279,1,980,1,"combretastatin.A.4, epothilone.b, KX2.391, oxibendazole, mebendazole",0,0,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.29583,-0.731,0.795,1327,0.912,"sunitinib, AMG.208, apatinib, BMS.599626",0.0996328713435297,0.0400051616715838,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.17047,-0.418,0.994,900,1,"vatalanib, linifanib, cabozantinib, regorafenib, ENMD.2076, foretinib, golvatinib, lucitanib, tivozanib, OSI.930, lenvatinib, AEE788, MGCD.265, sunitinib",0.00261361560268669,0,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",-0.5472,-1.36,0.152,1406,0.74,"maxacalcitol, ercalcitriol",0.818156412055227,0.130768280269024,FALSE
+"H1650","Pearson.est","EGFR inhibitor",-0.39467,-0.983,0.48,992,0.906,"canertinib, CNX.2006, WZ.4002, afatinib, gefitinib, osimertinib, ARRY.334543, CGP.52411, tyrphostin.AG.494, OSI.420, TAK.285, BMS.599626, PD.153035, BIBX.1382, pelitinib, icotinib, rociletinib, tyrphostin.AG.1478, vandetanib, erlotinib, PD.168393, WZ8040, BIBU.1361",0.318758762624413,0.0428718023231869,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",0.29248,0.778,0.726,1028,1,"GZD824, ponatinib, KW.2449, bafetinib, imatinib, tozasertib, flumatinib, dasatinib, metatinib, ZM.306416, bosutinib, nilotinib",0.139063379299906,0,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.53351,1.43,0.126,53,0.42,"xanomeline",0.899629454882437,0.3767507096021,FALSE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.26443,-0.647,0.878,938,1,"darifenacin, iododexetimide, diphemanil",0.0565054840938974,0,FALSE
+"H1650","Pearson.est","adenosine receptor antagonist",-0.33444,-0.82,0.68,1192,1,"sulmazole, istradefylline",0.167491087293764,0,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.32188,-0.806,0.666,1060,1,"isoxsuprine, xylazine, oxymetazoline, epinephrine, isoetharine",0.176525770829699,0,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",0.36487,0.952,0.479,172,0.892,"atenolol......, dihydroergocristine, naftidrofuryl, idazoxan",0.319664486585437,0.0496351456238769,FALSE
+"H1650","Pearson.est","AKT inhibitor",-0.3664,-0.908,0.555,1007,0.967,"GSK2110183, triciribine, palomid.529, AZD5363, CCT128930, AT7867",0.255707016877324,0.0145735259169983,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.21424,-0.532,0.963,1019,0.983,"NVP.TAE684, GW.788388, lorlatinib, AP26113",0.0163737128754655,0.00744648216786438,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.23792,-0.593,0.929,1251,1,"RU.58841",0.0319842860063582,0,FALSE
+"H1650","Pearson.est","antioxidant",-0.43411,-1.08,0.381,1077,1,"benfotiamine, mesna, rutin",0.419075024324381,0,FALSE
+"H1650","Pearson.est","AP inhibitor",-0.6377,-1.55,0.0479,1326,0.489,"embelin, tanshinone.i, GDC.0152",1.31966448658544,0.31069114087638,FALSE
+"H1650","Pearson.est","ATPase inhibitor",0.71133,1.9,0.0147,37,0.21,"k.strophanthidin, evodiamine, digoxin, NMS.873",1.83268266525182,0.677780705266081,TRUE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.25774,0.692,0.835,325,1,"CCT137690, CCT129202, PHA.680632, aurora.a.inhibitor.i, danusertib, barasertib.HQPA, barasertib, AMG900",0.0783135245163979,0,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.28305,0.75,0.753,279,0.999,"josamycin, azalomycin.b, azithromycin",0.123205023799299,0.000434511774017692,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.32318,-0.818,0.687,934,1,"trovafloxacin, sarafloxacin, novobiocin, finafloxacin",0.16304326294045,0,FALSE
+"H1650","Pearson.est","BCL inhibitor",0.50357,1.33,0.159,320,0.536,"venetoclax, gossypol, TW.37, oridonin",0.798602875679548,0.27083521030723,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.29207,0.765,0.739,1028,1,"GZD824, ponatinib, bafetinib, imatinib, tozasertib, flumatinib, dasatinib, metatinib, bosutinib, nilotinib",0.131355561605174,0,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",-0.27203,-0.671,0.841,1112,1,"zaleplon, CGS.20625, lorazepam",0.0752040042020878,0,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.33178,0.9,0.541,205,0.961,"PFI.1, I.BET.762",0.266802734893431,0.0172766123314547,FALSE
+"H1650","Pearson.est","calcium channel blocker",0.25784,0.689,0.842,171,0.984,"carboxyamidotriazole, SKF.96365",0.0746879085003505,0.00700490156865849,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",-0.43515,-1.07,0.37,1197,1,"MK.0812, RS.504393, navarixin",0.431798275933005,0,FALSE
+"H1650","Pearson.est","CDK inhibitor",0.41326,1.13,0.295,419,0.702,"PHA.848125, abemaciclib, indisulam, dinaciclib, AT.7519, BMS.387032, JNJ.7706621, alvocidib, P276.00, palbociclib, PHA.793887",0.530177984021837,0.153662887870195,FALSE
+"H1650","Pearson.est","CHK inhibitor",-0.39898,-0.986,0.476,888,0.935,"LY2606368, CHIR.124, SCH.900776, AZD7762",0.322393047279507,0.0291883891274822,FALSE
+"H1650","Pearson.est","cyclooxygenase inhibitor",-0.41974,-1.03,0.427,1092,0.992,"acetylsalicylsalicylic.acid, ketoprofen, amfenac, curcumin, tryptanthrin, indoprofen, pterostilbene, FR.122047, metoxibutropate, naproxen",0.369572124974976,0.00348832784582135,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",-0.467,-1.16,0.293,1246,0.905,"cobicistat, itraconazole",0.533132379645891,0.0433514207947967,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.30347,0.816,0.66,257,1,"carmustine, satraplatin, estramustine, mitomycin.c",0.180456064458131,0,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.26448,0.684,0.852,403,0.956,"carmustine, mechlorethamine, chlorambucil, sangivamycin, pibenzimol, bendamustine, teroxirone, carboplatin",0.0695604052332999,0.0195421077238999,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",-0.30344,-0.749,0.775,1214,1,"RG108, azacitidine",0.11069829749369,0,FALSE
+"H1650","Pearson.est","DNA polymerase inhibitor",-0.532,-1.31,0.149,1034,0.664,"adefovir.dipivoxil, famciclovir, cephalomannine, cidofovir",0.826813731587726,0.177831920631982,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",-0.31575,-0.792,0.709,1359,1,"CB.10.277, estramustine.phosphate",0.149353764816933,0,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",-0.5326,-1.32,0.173,1047,0.693,"domperidone, UH.232...., ziprasidone, raclopride, mesoridazine, amisulpride, acetophenazine, nemonapride, oxiperomide, remoxipride",0.761953896871205,0.159266765388193,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",-0.29227,-0.713,0.784,1223,1,"estradiol, PPT",0.105683937315562,0,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",-0.46631,-1.16,0.275,1147,0.905,"raloxifene, fulvestrant",0.560667306169737,0.0433514207947967,FALSE
+"H1650","Pearson.est","FGFR inhibitor",0.54992,1.46,0.0955,123,0.422,"dovitinib, nintedanib, erdafitinib, regorafenib, lenvatinib",1.01999662841625,0.374687549038326,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.24871,0.639,0.887,445,0.946,"dovitinib, tyrphostin.AG.1296, sorafenib, TG.101348, gilteritinib, ponatinib, KW.2449",0.0520763801682736,0.0241088635982073,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",-0.2338,-0.576,0.942,993,0.977,"clobetasol.propionate, triamcinolone, triamcinolone.acetonide, flumethasone.pivalate, piretanide, rimexolone, dexamethasone.acetate, difluprednate, fludroxycortide, prednisolone.acetate",0.0259490972071227,0.0101054362812269,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",-0.29826,-0.753,0.755,1046,1,"ACDPP, MTPG, CPP, latrepirdine, SIB.1757",0.122053048370812,0,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",-0.53822,-1.33,0.156,1319,0.728,"kenpaullone, LY2090314",0.806875401645538,0.137868620686963,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.682,1.84,0.0339,246,0.202,"PHA.848125, GSK1838705A, danusertib",1.46980030179692,0.694648630553376,TRUE
+"H1650","Pearson.est","HCV inhibitor",-0.79713,-2,0.00331,1310,0.0766,"Ro.9187, PSI.7976, embelin, narlaprevir",2.48017200622428,1.1157712303674,TRUE
+"H1650","Pearson.est","HDAC inhibitor",-0.50496,-1.25,0.197,1146,0.772,"SB.939, nexturastat.a, ACY.1215, RGFP966, tacedinaline, mocetinostat, romidepsin, entinostat, JNJ.26481585, RG2833",0.705533773838407,0.112382699664264,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",-0.57543,-1.45,0.103,975,0.536,"terfenadine, pheniramine, ranitidine, levocetirizine, astemizole, cimetidine, famotidine, BF2.649, tiotidine, lafutidine, ICI.162846, tecastemizole, chloropyramine",0.987162775294828,0.27083521030723,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.77928,-1.97,0,1245,0.0528,"mevastatin, atorvastatin, fluvastatin, pitavastatin, simvastatin",Inf,1.27736607746619,TRUE
+"H1650","Pearson.est","HSP inhibitor",-0.39599,-0.97,0.499,964,0.9,"BIIB021, NVP.AUY922, XL888, KW.2478, VER.49009, guanidine",0.30189945437661,0.0457574905606751,FALSE
+"H1650","Pearson.est","JAK inhibitor",-0.24908,-0.63,0.892,1028,1,"PRT062070, LY2784544, pacritinib, atiprimod",0.0496351456238769,0,FALSE
+"H1650","Pearson.est","KIT inhibitor",-0.31894,-0.783,0.733,1347,1,"midostaurin, vatalanib, telatinib",0.134896025358872,0,FALSE
+"H1650","Pearson.est","MDM inhibitor",-0.69778,-1.76,0.0141,1355,0.198,"CGM097, RITA",1.85078088734462,0.703334809738469,TRUE
+"H1650","Pearson.est","MEK inhibitor",-0.61198,-1.5,0.0792,1059,0.541,"refametinib, PD.198306, PD.0325901, BIX.02188, MEK162, U.0126, PD.318088, Ro.4987655, AZD8330, PD.184352, TAK.733",1.10127481841051,0.266802734893431,FALSE
+"H1650","Pearson.est","MET inhibitor",-0.42347,-1.05,0.392,1224,1,"PF.04217903",0.406713932979543,0,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.37545,0.999,0.464,118,0.833,"D.64131, vinblastine, vinflunine",0.333482019445119,0.0793549985932124,FALSE
+"H1650","Pearson.est","mTOR inhibitor",-0.23404,-0.582,0.932,1143,0.993,"palomid.529, XL388, deforolimus, torin.2, PF.05212384, sirolimus",0.0305840876460186,0.00305075150461883,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",-0.42049,-1.04,0.404,1129,1,"Ro.106.9920, bortezomib, curcumin, parthenolide...., BAY.11.7085",0.393618634889395,0,FALSE
+"H1650","Pearson.est","opioid receptor agonist",-0.3078,-0.761,0.743,1280,1,"ADL5859",0.129011186239425,0,FALSE
+"H1650","Pearson.est","p38 MAPK inhibitor",-0.41625,-1.02,0.431,1121,0.971,"skepinone.l, TAK.715, CMPD.1, VX.702",0.365522729839268,0.0127807700919951,FALSE
+"H1650","Pearson.est","PARP inhibitor",-0.301,-0.747,0.784,1205,0.984,"AZD2461, E7449",0.105683937315562,0.00700490156865849,FALSE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3129,0.838,0.645,123,1,"dovitinib, nintedanib, regorafenib, pazopanib, lenvatinib",0.190440285364732,0,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",0.37889,1.02,0.405,299,0.835,"GSK2830371, sodium.stibogluconate, AS.1949490, mycophenolic.acid, CID.5458317",0.392544976785331,0.0783135245163979,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",-0.41092,-1.01,0.436,1364,0.916,"GSK256066, papaverine",0.360513510731414,0.0381045263321496,FALSE
+"H1650","Pearson.est","PI3K inhibitor",0.20039,0.525,0.965,87,0.97,"idelalisib, buparlisib, alpelisib",0.0154726866562074,0.0132282657337552,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.7847,2.1,0.011,247,0.0862,"volasertib, NMS.1286937, GW.843682X, BI.2536, HMN.214, rigosertib",1.95860731484178,1.06449273417529,TRUE
+"H1650","Pearson.est","potassium channel blocker",-0.64346,-1.6,0.0456,1116,0.443,"mepivacaine, oleoylethanolamide, meglitinide",1.34103515733556,0.35359627377693,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",-0.71834,-1.79,0.0176,1163,0.21,"fenofibrate, S26948, pterostilbene, GW.501516, oleoylethanolamide",1.75448733218585,0.677780705266081,TRUE
+"H1650","Pearson.est","progesterone receptor agonist",-0.17936,-0.436,0.989,951,0.993,"tanaproget, melengestrol.acetate, norgestrel",0.0048037084028206,0.00305075150461883,FALSE
+"H1650","Pearson.est","proteasome inhibitor",-0.56283,-1.43,0.109,929,0.529,"carfilzomib, delanzomib, ixazomib, bortezomib, oprozomib, ixazomib.citrate, ONX.0914",0.962573502059376,0.276544327964814,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.55909,1.48,0.0899,307,0.443,"clofoctol, harringtonine, tedizolid.phosphate, homoharringtonine, anguidine, bruceantin, thiostrepton, puromycin, chloramphenicol.palmitate",1.04624030826677,0.35359627377693,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",0.44158,1.15,0.296,220,0.715,"PP.121, mubritinib, tyrphostin.A9, CP.724714",0.528708288941061,0.145693958198919,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.41194,1.11,0.316,322,0.696,"SB.590885, regorafenib, PLX.4720, sorafenib",0.500312917381596,0.157390760389438,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",-0.41081,-1.01,0.443,1296,0.916,"apatinib, vandetanib",0.35359627377693,0.0381045263321496,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",0.64234,1.68,0.0386,208,0.283,"adarotene, fenretinide, adapalene",1.41341269532825,0.54821356447571,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",0.43399,1.16,0.266,189,0.754,"pentostatin, cytarabine, hydroxyurea",0.575118363368933,0.122628654130226,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",0.43914,1.18,0.235,89,0.776,"zolmitriptan, pardoprunox",0.628932137728264,0.110138278741812,FALSE
+"H1650","Pearson.est","serotonin receptor antagonist",0.23899,0.645,0.876,175,0.971,"SB.200646, pirenperone, lurasidone",0.0574958938319193,0.0127807700919951,FALSE
+"H1650","Pearson.est","sodium channel blocker",-0.34649,-0.867,0.609,1108,1,"A.803467, mepivacaine, mexiletine, quinidine",0.215382707367125,0,FALSE
+"H1650","Pearson.est","src inhibitor",-0.24392,-0.6,0.932,351,1,"masitinib, KX2.391, saracatinib, TG.100572, dasatinib, ZM.306416, PP.1, bosutinib, PP.2",0.0305840876460186,0,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",0.27387,0.743,0.784,342,0.973,"chlormidazole, sulconazole, posaconazole",0.105683937315562,0.0118871597316481,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",-0.38097,-0.935,0.514,915,0.941,"repsox, SB.431542, D.4476",0.289036881004724,0.0264103765727431,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.59955,1.61,0.0463,533,0.315,"ftorafur, carmofur, raltitrexed, capecitabine, doxifluridine",1.33441900898205,0.501689446210399,FALSE
+"H1650","Pearson.est","topoisomerase inhibitor",-0.24579,-0.598,0.911,1031,1,"amonafide, TAS.103, rubitecan, idarubicin, licochalcone.a, fleroxacin, beta.lapachone, teniposide, voreloxin, etoposide, camptothecin",0.0404816230270017,0,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.61926,1.68,0.0477,427,0.283,"vindesine, oxibendazole, fenbendazole, vinblastine, docetaxel, vinorelbine, paclitaxel, verubulin, ABT.751, vincristine, BNC105, dolastatin.10, taltobulin, fosbretabulin, nocodazole, parbendazole, epothilone.b, mebendazole, KX2.391, CYT.997, albendazole",1.32148162095989,0.54821356447571,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.325,0.861,0.587,71,1,"PP.121, tivantinib, regorafenib, mubritinib",0.231361898752386,0,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.23408,0.625,0.918,123,0.93,"dovitinib, nintedanib, regorafenib, pazopanib, SAR131675, lenvatinib",0.0371573187987575,0.0315170514460649,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.60859,-1.48,0.085,1167,0.523,"tacalcitol, calcitriol, paricalcitol, ercalcitriol",1.07058107428571,0.281498311132726,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.30784,0.791,0.728,377,0.94,"neratinib, AEE788, tucatinib, GW.583340, CP.724714, lapatinib, OSI.420, CUDC.101, BMS.599626, dacomitinib, PD.153035, dovitinib, TAK.285",0.137868620686963,0.0268721464003014,FALSE
+"H1975","Pearson.est","Abl kinase inhibitor",-0.7007,-1.8,0.0121,1341,0.13,"flumatinib, GZD824, KW.2449, ponatinib, dasatinib",1.91721462968355,0.886056647693163,TRUE
+"H1975","Pearson.est","acetylcholine receptor agonist",0.29498,0.762,0.751,341,0.942,"pilocarpine, tremorine, oxiracetam",0.124360062995832,0.0259490972071227,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",0.74434,1.88,0.00524,258,0.121,"diphemanil, darifenacin, hyoscyamine, dicycloverine",2.28066871301627,0.91721462968355,TRUE
+"H1975","Pearson.est","adenosine receptor antagonist",0.3074,0.798,0.66,248,0.979,"CGS.15943, PSB.1115",0.180456064458131,0.00921730819686218,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",0.30757,0.786,0.695,77,0.925,"lidamidine, methyldopa",0.158015195409886,0.0338582672609674,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",0.37889,0.969,0.494,295,0.924,"RS.17053, idazoxan, prazosin, carvedilol, vincamine, levobunolol",0.306273051076353,0.0343280287798933,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.28941,0.731,0.783,156,0.946,"uprosertib, triciribine, A.674563",0.106238237942057,0.0241088635982073,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.23109,-0.603,0.92,1144,0.948,"alectinib, brigatinib, lorlatinib, AP26113",0.0362121726544447,0.0231916626619338,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",0.52762,1.34,0.165,627,0.549,"cyproterone.acetate, enzalutamide, flutamide, nilutamide, bicalutamide",0.782516055786094,0.260427655549908,FALSE
+"H1975","Pearson.est","antioxidant",-0.78841,-2.07,0.00231,1367,0.0421,"trolox, mesna, benfotiamine",2.63638802010786,1.37571790416433,TRUE
+"H1975","Pearson.est","AP inhibitor",0.27155,0.69,0.807,393,0.939,"tanshinone.i, LCL.161",0.0931264652779296,0.0273344077338891,FALSE
+"H1975","Pearson.est","ATPase inhibitor",-0.36236,-0.954,0.487,1356,0.836,"k.strophanthidin, oligomycin.a",0.312471038785366,0.0777937225609836,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",-0.6042,-1.64,0.0641,1105,0.221,"ZM.447439, TAK.901, MLN.8054, CCT129202, hesperadin, AMG900, MK.8745, barasertib, barasertib.HQPA, alisertib, KW.2449, SNS.314, GSK1070916, CYC116, AT.9283",1.19314197048118,0.655607726314889,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.55257,1.39,0.13,153,0.568,"azithromycin, azalomycin.b, dirithromycin",0.886056647693163,0.245651664288981,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.51387,-1.36,0.149,1388,0.421,"novobiocin, finafloxacin",0.826813731587726,0.375717904164332,FALSE
+"H1975","Pearson.est","BCL inhibitor",-0.32569,-0.847,0.633,469,0.877,"obatoclax, HA14.1, oridonin, venetoclax, navitoclax, ABT.737, TW.37, gossypol",0.198596289982645,0.0570004066339595,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.70947,-1.96,0.00442,1341,0.0748,"flumatinib, GZD824, ponatinib, dasatinib",2.35457773065091,1.12609840213554,TRUE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.2381,0.611,0.895,635,1,"indiplon, zaleplon, ZK.93423, temazepam, eprinomectin, piperazine, nefiracetam, CL.218872, bentazepam",0.048176964684088,0,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",0.39228,1,0.442,93,0.921,"JQ1....",0.354577730650908,0.0357403698031511,FALSE
+"H1975","Pearson.est","calcium channel blocker",0.43051,1.1,0.326,219,0.799,"fendiline, tetrandrine, SKF.96365",0.486782399932061,0.0974532206860086,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",0.44924,1.16,0.28,563,0.74,"PF.04136309, MK.0812, ZK811752, navarixin, SB.225002, RS.504393",0.552841968657781,0.130768280269024,FALSE
+"H1975","Pearson.est","CDK inhibitor",0.36864,0.927,0.548,362,0.954,"BMS.387032, arcyriaflavin.a, JNJ.7706621, PHA.793887, AZD5438, kenpaullone, dinaciclib, alvocidib, CR8..R., BMS.265246",0.261219441515631,0.0204516252959049,FALSE
+"H1975","Pearson.est","CHK inhibitor",0.7286,1.85,0.00539,96,0.116,"PF.477736, SB.218078, CHIR.124",2.26841123481326,0.935542010773082,TRUE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.30811,-0.825,0.643,1343,0.841,"sulfasalazine, metoxibutropate, ketoprofen, tepoxalin",0.191789027075778,0.0752040042020878,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.66556,-1.76,0.032,1243,0.136,"cobicistat, itraconazole, eplerenone",1.49485002168009,0.866461091629782,TRUE
+"H1975","Pearson.est","DNA alkylating agent",0.43847,1.13,0.321,283,0.77,"dacarbazine, mitomycin.c, melphalan, ifosfamide, estramustine, satraplatin",0.493494967595128,0.113509274827518,FALSE
+"H1975","Pearson.est","DNA inhibitor",0.30985,0.801,0.674,293,1,"melphalan, busulfan, metronidazole, primaquine, bendamustine",0.17134010346468,0,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.60535,1.51,0.0668,297,0.461,"SGI.1027, fdcyd, azacitidine, disulfiram",1.17522353752445,0.336299074610352,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",0.23252,0.585,0.916,211,0.989,"trifluridine",0.0381045263321496,0.0048037084028206,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",0.34019,0.864,0.598,231,0.965,"mitomycin.c, enocitabine, floxuridine",0.223298816011589,0.0154726866562074,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",-0.31192,-0.833,0.654,1273,0.864,"UH.232...., thioproperazine, oxiperomide, nemonapride, raclopride, acetophenazine",0.184422251675733,0.0634862575211067,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.37253,-1.01,0.418,989,0.869,"ethinyl.estradiol, estradiol, PPT, estrone",0.378823718224965,0.0609802235513335,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",0.65951,1.71,0.0234,446,0.267,"danazol, toremifene, clomifene, raloxifene, tamoxifen",1.63078414258986,0.573488738635425,FALSE
+"H1975","Pearson.est","FGFR inhibitor",0.52125,1.35,0.152,143,0.567,"regorafenib, lenvatinib, lucitanib",0.818156412055227,0.246416941107093,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",-0.32192,-0.853,0.626,1376,0.909,"KW.2449, ponatinib, midostaurin",0.20342566678957,0.0414361167780325,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",-0.50338,-1.3,0.176,1155,0.433,"prednisolone.hemisuccinate, flumethasone.pivalate, fluocinolone.acetonide, prednisolone, prednisolone.acetate, dexamethasone.acetate, desonide, hydrocortisone, beclomethasone.dipropionate, fluticasone.propionate, piretanide, triamcinolone",0.75448733218585,0.363512103646635,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",0.42402,1.08,0.355,338,0.775,"CGP.37849, MTPG, diazooxonorleucine, IEM1754, CPP, tiletamine, ACDPP",0.449771646944906,0.11069829749369,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",0.22708,0.571,0.933,43,0.98,"AZD2858",0.0301183562535,0.00877392430750515,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",0.34018,0.854,0.625,53,0.956,"GW.441756",0.204119982655925,0.0195421077238999,FALSE
+"H1975","Pearson.est","HCV inhibitor",0.65648,1.66,0.0309,80,0.262,"PSI.7976, daclatasvir",1.51004152057517,0.581698708680255,FALSE
+"H1975","Pearson.est","HDAC inhibitor",-0.22407,-0.592,0.904,1413,0.926,"RG2833, mocetinostat",0.0438315695246367,0.0333890133180656,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",0.33009,0.843,0.66,126,0.95,"zolantidine, tecastemizole, cyproheptadine, astemizole",0.180456064458131,0.0222763947111523,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.77855,-2.08,0.00212,1211,0.0765,"lovastatin, simvastatin, atorvastatin, fluvastatin, pitavastatin",2.67366413907125,1.11633856484638,TRUE
+"H1975","Pearson.est","HSP inhibitor",0.17672,0.463,0.988,331,0.989,"XL888, NMS.E973, SNX.2112",0.00524305541237188,0.0048037084028206,FALSE
+"H1975","Pearson.est","JAK inhibitor",0.37282,0.935,0.514,200,0.968,"LY2784544, baricitinib, TG.101348, pacritinib, AZD1480, CEP.33779",0.289036881004724,0.0141246426916063,FALSE
+"H1975","Pearson.est","KIT inhibitor",-0.36785,-0.976,0.44,1421,0.835,"midostaurin, dasatinib, KI.8751",0.356547323513813,0.0783135245163979,FALSE
+"H1975","Pearson.est","MDM inhibitor",-0.52258,-1.37,0.132,1064,0.498,"CGM097, idasanutlin, serdemetan, AMG.232, RITA",0.87942606879415,0.302770657240282,FALSE
+"H1975","Pearson.est","MEK inhibitor",-0.72228,-1.93,0.00883,1190,0.0718,"PD.198306, MEK162, cobimetinib, PD.98059, U.0126, AS.703026, trametinib, Ro.4987655, selumetinib, TAK.733, refametinib, AZD8330, PD.318088, PD.184352",2.05403929642243,1.1438755557577,TRUE
+"H1975","Pearson.est","MET inhibitor",-0.25848,-0.676,0.824,1186,0.935,"PF.04217903, LY2801653",0.0840727883028842,0.0291883891274822,FALSE
+"H1975","Pearson.est","microtubule inhibitor",0.39257,0.989,0.463,454,0.911,"colchicine, D.64131, podophyllotoxin, triclabendazole, vinflunine",0.334419008982047,0.0404816230270017,FALSE
+"H1975","Pearson.est","mTOR inhibitor",-0.51375,-1.36,0.129,1140,0.421,"deforolimus, WYE.354, GDC.0980, OSI.027, PKI.179, MLN0128, everolimus, LY3023414, torin.1, temsirolimus, PF.04691502, NVP.BEZ235, SB.2343",0.889410289700751,0.375717904164332,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",-0.24944,-0.651,0.874,1167,0.932,"BAY.11.7085, EVP4593, BAY.11.7082",0.058488567365597,0.0305840876460186,FALSE
+"H1975","Pearson.est","opioid receptor agonist",0.35097,0.891,0.562,16,0.968,"salvinorin.a",0.250263684430939,0.0141246426916063,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",0.55923,1.44,0.104,322,0.562,"talmapimod, SB.242235, SB.239063, TAK.715",0.98296666070122,0.250263684430939,FALSE
+"H1975","Pearson.est","PARP inhibitor",0.50882,1.3,0.186,21,0.525,"PJ.34",0.730487055782084,0.279840696594043,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.39575,-1.04,0.376,1309,0.862,"linifanib, SU014813, axitinib, ponatinib, dasatinib, KI.8751",0.424812155072339,0.0644927341752872,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",0.23457,0.593,0.928,332,1,"AS.1949490, mycophenolic.acid",0.0324520237811379,0,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",0.29214,0.737,0.789,334,0.959,"cilostamide, YM.976, enoximone",0.10292299679058,0.0181813928293364,FALSE
+"H1975","Pearson.est","PI3K inhibitor",-0.38214,-0.984,0.451,1157,0.868,"GDC.0980, PI3K.IN.2, BGT226, PKI.179, ZSTK.474, LY3023414, buparlisib, GDC.0941, PF.04691502, NVP.BEZ235, SB.2343",0.345823458122039,0.0614802748235081,FALSE
+"H1975","Pearson.est","PLK inhibitor",0.67024,1.7,0.0294,311,0.239,"BI.2536, NMS.1286937, GSK461364, GW.843682X, volasertib",1.53165266958784,0.621602099051862,TRUE
+"H1975","Pearson.est","potassium channel blocker",0.42929,1.08,0.368,305,0.775,"dofetilide, oleoylethanolamide, ML133",0.434152181326482,0.11069829749369,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",-0.34142,-0.878,0.584,1065,0.903,"clofibrate, pterostilbene, fenofibrate",0.233587152887601,0.0443122496864942,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.48485,-1.31,0.18,1194,0.454,"norgestrel, norethindrone, tanaproget",0.744727494896694,0.342944147142896,FALSE
+"H1975","Pearson.est","proteasome inhibitor",0.54073,1.41,0.109,567,0.574,"MG.132, ixazomib, delanzomib, carfilzomib, bortezomib",0.962573502059376,0.241088107602027,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.45514,1.16,0.277,426,0.74,"bruceantin, homoharringtonine, harringtonine, puromycin, chloramphenicol.palmitate, clofoctol, thiostrepton, anguidine, emetine, tedizolid.phosphate",0.557520230935551,0.130768280269024,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.34072,0.877,0.614,290,0.967,"tyrphostin.A9, CP.724714, AV.412, BMS.599626",0.211831628858832,0.0145735259169983,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.53115,1.35,0.147,557,0.567,"regorafenib, SB.590885, AZ.628, CEP.32496, GDC.0879, vemurafenib, LGX818, dabrafenib, RAF265, sorafenib",0.832682665251824,0.246416941107093,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.36759,0.921,0.51,236,0.935,"regorafenib, apatinib",0.292429823902064,0.0291883891274822,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.60436,1.53,0.0828,198,0.476,"adarotene, AM.580, tamibarotene, CD.437",1.08196966321512,0.322393047279507,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",0.19065,0.485,0.991,473,1,"fludarabine.phosphate, gemcitabine, fludarabine",0.00392634551472468,0,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",-0.52503,-1.38,0.147,1447,0.541,"aripiprazole",0.832682665251824,0.266802734893431,FALSE
+"H1975","Pearson.est","serotonin receptor antagonist",-0.28748,-0.762,0.727,1447,0.878,"aripiprazole",0.138465589140962,0.0565054840938974,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.30052,-0.796,0.66,1038,0.855,"A.803467, oxcarbazepine, benzocaine, mexiletine, benzethonium, mepivacaine",0.180456064458131,0.0680338852718274,FALSE
+"H1975","Pearson.est","src inhibitor",0.28521,0.728,0.772,298,0.929,"KX2.391, TG.100572, saracatinib",0.112382699664264,0.0319842860063582,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",0.31027,0.793,0.714,403,0.961,"ketoconazole, lanoconazole, posaconazole",0.146301788223826,0.0172766123314547,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.74997,1.92,0.0053,307,0.246,"LY2109761, SB.525334, repsox, D.4476",2.27572413039921,0.609064892896621,TRUE
+"H1975","Pearson.est","thymidylate synthase inhibitor",0.73976,1.91,0.00735,292,0.134,"ftorafur, doxifluridine, raltitrexed, trifluridine, carmofur",2.13371266091581,0.872895201635192,TRUE
+"H1975","Pearson.est","topoisomerase inhibitor",0.27317,0.695,0.823,249,0.954,"dexrazoxane, SN.38, exatecan.mesylate, genz.644282, camptothecin, topotecan",0.0846001647877302,0.0204516252959049,FALSE
+"H1975","Pearson.est","tubulin polymerization inhibitor",0.50617,1.3,0.192,397,0.525,"vinorelbine, vincristine, KX2.391, CYT.997, combretastatin.A.4, taltobulin, oxibendazole, podophyllotoxin, plinabulin, dolastatin.10, albendazole, indibulin",0.71669877129645,0.279840696594043,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",-0.35049,-0.948,0.491,1322,0.805,"mubritinib, cabozantinib, aminopurvalanol.a, UNC2250, dasatinib, NVP.TAE226",0.308918507877032,0.0942041196321315,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",-0.26555,-0.72,0.782,1309,0.909,"linifanib, semaxanib, SAR131675, SU014813, cabozantinib, axitinib, KI.8751",0.106793246940152,0.0414361167780325,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.50276,1.31,0.182,34,0.571,"maxacalcitol",0.739928612014925,0.243363891754152,FALSE
+"H2009","Pearson.est","EGFR inhibitor",-0.29935,-0.734,0.82,1028,0.896,"rociletinib, osimertinib, OSI.420, tyrphostin.AG.494, pelitinib, canertinib, WZ8040, gefitinib, PD.153035, afatinib, erlotinib, TAK.285, icotinib, BIBX.1382, tyrphostin.AG.1478, BIBU.1361",0.0861861476162833,0.0476919903378748,FALSE
+"H2009","Pearson.est","Abl kinase inhibitor",-0.23614,-0.59,0.932,1275,0.961,"bafetinib, bosutinib",0.0305840876460186,0.0172766123314547,FALSE
+"H2009","Pearson.est","acetylcholine receptor agonist",0.28183,0.785,0.702,35,0.905,"xanomeline",0.153662887870195,0.0433514207947967,FALSE
+"H2009","Pearson.est","acetylcholine receptor antagonist",-0.49055,-1.2,0.247,1281,0.891,"dicycloverine, diphemanil",0.607303046740334,0.0501222959631252,FALSE
+"H2009","Pearson.est","adenosine receptor antagonist",-0.47233,-1.19,0.267,1080,0.872,"SCH.58261, CGS.15943, sulmazole",0.573488738635425,0.0594835150674328,FALSE
+"H2009","Pearson.est","adrenergic receptor agonist",-0.28913,-0.716,0.809,755,0.901,"norepinephrine, xylazine, terbutaline, oxymetazoline, A61603, metaraminol, isoxsuprine, clenbuterol, buphenine, epinephrine",0.0920514783877277,0.045275209020937,FALSE
+"H2009","Pearson.est","adrenergic receptor antagonist",-0.36146,-0.895,0.594,1256,0.911,"carvedilol, pindolol, levobunolol, propranolol, vincamine",0.226213555018806,0.0404816230270017,FALSE
+"H2009","Pearson.est","AKT inhibitor",-0.42941,-1.07,0.365,951,0.849,"AZD5363, GDC.0068, ONC201, CCT128930, uprosertib, triciribine, palomid.529",0.437707135543525,0.0710923097560473,FALSE
+"H2009","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4148,-1.03,0.414,844,0.855,"lorlatinib, crizotinib, NVP.TAE684, DMH1, AZD3463, GW.788388",0.382999658879101,0.0680338852718274,FALSE
+"H2009","Pearson.est","androgen receptor antagonist",-0.38341,-0.948,0.535,883,0.876,"cyproterone.acetate, flutamide, nilutamide, bicalutamide",0.271646217978772,0.0574958938319193,FALSE
+"H2009","Pearson.est","antioxidant",0.37078,1.05,0.385,20,0.941,"trolox",0.414539270491499,0.0264103765727431,FALSE
+"H2009","Pearson.est","AP inhibitor",-0.27927,-0.683,0.851,830,0.909,"birinapant, embelin, GDC.0152, tanshinone.i, LCL.161",0.0700704399154121,0.0414361167780325,FALSE
+"H2009","Pearson.est","ATPase inhibitor",0.71635,2.03,0.00746,245,0.211,"k.strophanthidin, oligomycin.a, omeprazole, NMS.873, digoxin, evodiamine, blebbistatin....",2.12726117252733,0.675717544702307,TRUE
+"H2009","Pearson.est","Aurora kinase inhibitor",-0.2121,-0.526,0.963,754,0.966,"AMG900, CCT137690, alisertib, tozasertib, GSK1070916, MK.8745, KW.2449, ZM.447439, hesperadin, MK.5108, PF.03814735, MLN.8054",0.0163737128754655,0.0150228735845067,FALSE
+"H2009","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.37131,-0.895,0.584,868,0.911,"dirithromycin, tedizolid, azalomycin.b, azithromycin",0.233587152887601,0.0404816230270017,FALSE
+"H2009","Pearson.est","bacterial DNA gyrase inhibitor",-0.40766,-1.01,0.446,856,0.845,"lomefloxacin, sarafloxacin, finafloxacin, novobiocin, trovafloxacin",0.350665141287858,0.0731432910503077,FALSE
+"H2009","Pearson.est","BCL inhibitor",0.38793,1.11,0.322,363,0.892,"ABT.737, gossypol, TW.37, venetoclax, navitoclax, obatoclax",0.492144128304169,0.0496351456238769,FALSE
+"H2009","Pearson.est","Bcr.Abl kinase inhibitor",-0.31054,-0.769,0.764,1275,0.899,"bafetinib, bosutinib",0.11690664142431,0.0462403082667712,FALSE
+"H2009","Pearson.est","benzodiazepine receptor agonist",-0.34366,-0.844,0.662,788,0.896,"gamma.aminobutyric.acid, ivermectin, piperazine, indiplon, CGS.20625, ZK.93423, zaleplon",0.1791420105603,0.0476919903378748,FALSE
+"H2009","Pearson.est","bromodomain inhibitor",-0.36322,-0.891,0.609,738,0.875,"I.BET151, I.BET.762, bromosporine, JQ1....",0.215382707367125,0.0579919469776868,FALSE
+"H2009","Pearson.est","calcium channel blocker",0.31958,0.913,0.556,83,0.87,"efonidipine.monoethanolate, carboxyamidotriazole",0.254925208417942,0.0604807473813815,FALSE
+"H2009","Pearson.est","CC chemokine receptor antagonist",-0.46745,-1.16,0.288,1201,0.828,"MK.0812, PF.04136309, navarixin",0.540607512240769,0.0819696632151199,FALSE
+"H2009","Pearson.est","CDK inhibitor",-0.4684,-1.15,0.308,1312,0.817,"arcyriaflavin.a, BMS.387032, kenpaullone, PHA.793887, AZD5438, alvocidib",0.511449283499556,0.0877779434675845,FALSE
+"H2009","Pearson.est","CHK inhibitor",-0.46918,-1.17,0.276,807,0.841,"CHIR.124, SCH.900776, SB.218078, LY2603618, LY2606368",0.559090917934782,0.0752040042020878,FALSE
+"H2009","Pearson.est","cyclooxygenase inhibitor",-0.51028,-1.26,0.202,1207,0.863,"FR.122047, meloxicam, indoprofen, amfenac, curcumin, ramifenazone, aspirin, FK.3311",0.694648630553376,0.0639892042847904,FALSE
+"H2009","Pearson.est","cytochrome P450 inhibitor",-0.35944,-0.891,0.595,981,0.875,"cobicistat, clotrimazole, PF.4981517",0.22548303427145,0.0579919469776868,FALSE
+"H2009","Pearson.est","DNA alkylating agent",-0.53922,-1.35,0.136,923,0.826,"ifosfamide, satraplatin, dianhydrogalactitol, TH.302, cyclophosphamide, mitomycin.c, carboplatin, streptozotocin, melphalan, dacarbazine",0.866461091629782,0.0830199526796178,FALSE
+"H2009","Pearson.est","DNA inhibitor",-0.42381,-1.05,0.402,984,0.866,"primaquine, valrubicin, nimorazole, tirapazamine, carboplatin, sangivamycin, bendamustine, busulfan, melphalan, nithiamide",0.39577394691553,0.0624821079826534,FALSE
+"H2009","Pearson.est","DNA methyltransferase inhibitor",-0.63065,-1.54,0.0433,1093,0.445,"fdcyd, SGI.1027, decitabine, azacitidine",1.36351210364663,0.351639989019068,FALSE
+"H2009","Pearson.est","DNA polymerase inhibitor",0.31384,0.872,0.58,201,0.9,"menadione, adefovir.dipivoxil, cidofovir",0.236572006437063,0.0457574905606751,FALSE
+"H2009","Pearson.est","DNA synthesis inhibitor",-0.54155,-1.36,0.144,1076,0.876,"mitomycin.c, estramustine.phosphate, cyclocytidine, anisomycin, CB.10.277, floxuridine, altretamine",0.84163750790475,0.0574958938319193,FALSE
+"H2009","Pearson.est","dopamine receptor antagonist",-0.32924,-0.813,0.69,933,0.87,"oxiperomide, acetophenazine, sertindole, ziprasidone, amisulpride, piperacetazine, isofloxythepin",0.161150909262745,0.0604807473813815,FALSE
+"H2009","Pearson.est","estrogen receptor agonist",-0.35421,-0.883,0.603,1139,0.849,"estradiol.cypionate, PPT, ethinyl.estradiol",0.219682687859849,0.0710923097560473,FALSE
+"H2009","Pearson.est","estrogen receptor antagonist",-0.37333,-0.912,0.573,804,0.926,"danazol, fulvestrant, clomifene, raloxifene, toremifene",0.24184537803261,0.0333890133180656,FALSE
+"H2009","Pearson.est","FGFR inhibitor",0.48853,1.4,0.103,127,0.578,"erdafitinib, lenvatinib, dovitinib",0.987162775294828,0.238072161579471,FALSE
+"H2009","Pearson.est","FLT3 inhibitor",0.35304,0.968,0.471,191,0.961,"ponatinib, TG.101348, sorafenib, dovitinib, GTP.14564, ENMD.2076",0.326979092871104,0.0172766123314547,FALSE
+"H2009","Pearson.est","glucocorticoid receptor agonist",0.59023,1.66,0.0497,290,0.384,"dexamethasone.acetate, triamcinolone.acetonide, hydrocortisone, halcinonide, beclomethasone.dipropionate, triamcinolone, desonide, flumethasone.pivalate, deflazacort, fluticasone.propionate, piretanide, betamethasone, rimexolone, fluocinolone.acetonide, prednisolone.hemisuccinate, ciclesonide",1.30364361126667,0.415668775632469,FALSE
+"H2009","Pearson.est","glutamate receptor antagonist",-0.40306,-1.01,0.45,869,0.845,"JNJ.16259685, MTPG, SIB.1757, tiletamine, ACDPP, latrepirdine, diazooxonorleucine",0.346787486224656,0.0731432910503077,FALSE
+"H2009","Pearson.est","glycogen synthase kinase inhibitor",-0.49142,-1.22,0.239,847,0.94,"CHIR.99021, tideglusib, LY2090314, GSK.3.inhibitor.IX, kenpaullone, AZD2858",0.621602099051862,0.0268721464003014,FALSE
+"H2009","Pearson.est","growth factor receptor inhibitor",-0.2862,-0.704,0.845,962,0.9,"GSK1838705A, AZD3463, GW.441756",0.0731432910503077,0.0457574905606751,FALSE
+"H2009","Pearson.est","HCV inhibitor",-0.6967,-1.72,0.0195,1354,0.474,"narlaprevir, PSI.7976, daclatasvir",1.70996538863748,0.324221658325915,FALSE
+"H2009","Pearson.est","HDAC inhibitor",-0.46157,-1.14,0.307,902,0.807,"pyroxamide, dacinostat, nexturastat.a, givinostat, chidamide, entinostat, M.344, AR.42, tacedinaline, romidepsin, PCI.24781, R306465, vorinostat, panobinostat, JNJ.26481585, SB.939",0.512861624522813,0.0931264652779296,FALSE
+"H2009","Pearson.est","histamine receptor antagonist",-0.53774,-1.32,0.168,886,0.727,"ranitidine, astemizole, tiotidine, cyproheptadine, levocetirizine, cimetidine, ICI.162846, nizatidine, famotidine, lafutidine, pheniramine, tecastemizole, terfenadine, chloropyramine, zolantidine",0.774690718274137,0.138465589140962,FALSE
+"H2009","Pearson.est","HMGCR inhibitor",-0.31223,-0.771,0.736,1018,0.914,"simvastatin, mevastatin",0.133122185662501,0.0390538042661686,FALSE
+"H2009","Pearson.est","HSP inhibitor",-0.55629,-1.37,0.124,1110,0.942,"VER.49009, SNX.2112, BIIB021, PU.H71, NVP.AUY922, tanespimycin, XL888, SNX.5422",0.906578314837765,0.0259490972071227,FALSE
+"H2009","Pearson.est","JAK inhibitor",-0.33464,-0.837,0.656,1204,0.889,"pacritinib, atiprimod, CEP.33779, WHI.P154, LY2784544",0.18309616062434,0.0510982390297863,FALSE
+"H2009","Pearson.est","KIT inhibitor",0.26596,0.762,0.716,340,0.896,"lenvatinib, sorafenib, pazopanib, dasatinib, motesanib, cediranib, midostaurin",0.145086977692144,0.0476919903378748,FALSE
+"H2009","Pearson.est","MDM inhibitor",-0.40087,-0.979,0.495,853,0.862,"RITA, nutlin.3, serdemetan",0.305394801066431,0.0644927341752872,FALSE
+"H2009","Pearson.est","MEK inhibitor",-0.30345,-0.748,0.76,742,0.894,"cobimetinib, PD.184352, PD.98059, AS.703026, arctigenin, PD.0325901, trametinib, TAK.733, Ro.4987655, PD.198306, BIX.02188, nobiletin",0.119186407719209,0.0486624812040823,FALSE
+"H2009","Pearson.est","MET inhibitor",-0.67304,-1.64,0.028,1070,0.331,"LY2801653, AMG458, PF.04217903, NVP.BVU972, INC.280",1.55284196865778,0.480172006224281,FALSE
+"H2009","Pearson.est","microtubule inhibitor",-0.45286,-1.1,0.379,1119,0.808,"estramustine.phosphate, cabazitaxel, D.64131, podophyllotoxin",0.421360790031928,0.0925886392254138,FALSE
+"H2009","Pearson.est","mTOR inhibitor",0.31171,0.861,0.569,212,0.814,"OSI.027, torin.1, WYE.354, PF.04691502, voxtalisib, XL388, SB.2343, AZD2014, everolimus, WYE.125132",0.244887733604929,0.0893755951107988,FALSE
+"H2009","Pearson.est","NFkB pathway inhibitor",0.34127,0.935,0.495,25,0.888,"EVP4593, tyloxapol",0.305394801066431,0.051587034221399,FALSE
+"H2009","Pearson.est","opioid receptor agonist",-0.44161,-1.1,0.353,1436,0.808,"salvinorin.a",0.452225294612177,0.0925886392254138,FALSE
+"H2009","Pearson.est","p38 MAPK inhibitor",-0.66877,-1.66,0.0233,1356,0.49,"VX.702, TAK.715, CMPD.1",1.63264407897398,0.309803919971486,FALSE
+"H2009","Pearson.est","PARP inhibitor",-0.52849,-1.32,0.151,1043,0.727,"talazoparib, niraparib, olaparib, PJ.34",0.821023052706831,0.138465589140962,FALSE
+"H2009","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.39997,1.14,0.285,276,0.932,"axitinib, ponatinib, lenvatinib, linifanib, sorafenib, dovitinib, SU014813, pazopanib, dasatinib, nintedanib, motesanib",0.54515513999149,0.0305840876460186,FALSE
+"H2009","Pearson.est","phosphatase inhibitor",0.34829,0.997,0.443,178,0.98,"GSK2830371, CID.5458317, menadione",0.35359627377693,0.00877392430750515,FALSE
+"H2009","Pearson.est","phosphodiesterase inhibitor",-0.44568,-1.12,0.334,1213,0.822,"cilostamide, zardaverine, YM.976, EMD.53998",0.476253533188435,0.0851281824599496,FALSE
+"H2009","Pearson.est","PI3K inhibitor",0.23092,0.672,0.851,329,0.98,"ZSTK.474, GDC.0941, PF.04691502, PI3K.IN.2, voxtalisib, SB.2343, buparlisib, LY3023414, PI.828, TG100.115, idelalisib",0.0700704399154121,0.00877392430750515,FALSE
+"H2009","Pearson.est","PLK inhibitor",-0.47468,-1.17,0.251,888,0.841,"GW.843682X, GSK461364, HMN.214, BI.2536",0.600326278518962,0.0752040042020878,FALSE
+"H2009","Pearson.est","potassium channel blocker",-0.53939,-1.34,0.123,1248,0.785,"oleoylethanolamide, meglitinide",0.910094888560602,0.105130343254747,FALSE
+"H2009","Pearson.est","PPAR receptor agonist",0.22181,0.618,0.888,173,0.95,"fenofibrate, clofibrate",0.051587034221399,0.0222763947111523,FALSE
+"H2009","Pearson.est","progesterone receptor agonist",0.54162,1.54,0.0641,171,0.441,"norethindrone, tanaproget, levonorgestrel",1.19314197048118,0.355561410532161,FALSE
+"H2009","Pearson.est","proteasome inhibitor",-0.68297,-1.65,0.0192,997,0.389,"carfilzomib, MG.132, ONX.0914, bortezomib, delanzomib, ixazomib.citrate, ixazomib",1.71669877129645,0.410050398674292,FALSE
+"H2009","Pearson.est","protein synthesis inhibitor",-0.23175,-0.57,0.94,943,0.958,"mercaptopurine, brefeldin.a, azomycin..2.nitroimidazole., thiostrepton, puromycin, homoharringtonine, emetine",0.0268721464003014,0.0186344909214556,FALSE
+"H2009","Pearson.est","protein tyrosine kinase inhibitor",0.48737,1.35,0.172,42,0.572,"mubritinib, PP.121",0.764471553092451,0.242603971206976,FALSE
+"H2009","Pearson.est","RAF inhibitor",-0.41604,-1.04,0.399,1208,0.861,"vemurafenib, GDC.0879, dabrafenib, CEP.32496, LGX818",0.399027104313252,0.0649968485463452,FALSE
+"H2009","Pearson.est","RET tyrosine kinase inhibitor",-0.27293,-0.68,0.852,774,0.896,"regorafenib, cabozantinib, vandetanib, apatinib",0.0695604052332999,0.0476919903378748,FALSE
+"H2009","Pearson.est","retinoid receptor agonist",-0.39098,-0.981,0.489,1181,0.884,"tamibarotene, AM.580, CD.437",0.31069114087638,0.0535477349869269,FALSE
+"H2009","Pearson.est","ribonucleotide reductase inhibitor",-0.32887,-0.822,0.687,1225,0.875,"clofarabine, fludarabine.phosphate, fludarabine",0.16304326294045,0.0579919469776868,FALSE
+"H2009","Pearson.est","serotonin receptor agonist",0.66134,1.82,0.0179,103,0.291,"aripiprazole, zolmitriptan",1.74714696902011,0.536107011014093,FALSE
+"H2009","Pearson.est","serotonin receptor antagonist",0.2989,0.863,0.601,2,0.861,"aripiprazole",0.22112552799726,0.0649968485463452,FALSE
+"H2009","Pearson.est","sodium channel blocker",0.19438,0.552,0.976,120,0.959,"cibenzoline, benzethonium",0.0105501823333082,0.0181813928293364,FALSE
+"H2009","Pearson.est","src inhibitor",-0.38418,-0.949,0.528,1029,0.899,"PP.2, saracatinib, KX2.391, bosutinib",0.277366077466188,0.0462403082667712,FALSE
+"H2009","Pearson.est","sterol demethylase inhibitor",-0.35868,-0.89,0.589,1237,0.857,"ketoconazole, lanoconazole",0.229884705212898,0.0670191780768018,FALSE
+"H2009","Pearson.est","TGF beta receptor inhibitor",-0.66209,-1.63,0.0352,1369,0.298,"D.4476, LY2109761",1.45345733652187,0.525783735923745,FALSE
+"H2009","Pearson.est","thymidylate synthase inhibitor",-0.77207,-1.92,0.00424,1259,0.14,"raltitrexed, carmofur, doxifluridine",2.37263414340727,0.853871964321762,TRUE
+"H2009","Pearson.est","topoisomerase inhibitor",-0.4855,-1.2,0.229,944,0.891,"TAS.103, teniposide, valrubicin, etoposide, amsacrine, topotecan, amonafide, irinotecan, nemorubicin, rubitecan, licochalcone.a, SN.38, camptothecin, genz.644282, exatecan.mesylate",0.640164517660112,0.0501222959631252,FALSE
+"H2009","Pearson.est","tubulin polymerization inhibitor",-0.33092,-0.822,0.682,1086,0.875,"mebendazole, epothilone.b, epothilone.d, fosbretabulin, podophyllotoxin, KX2.391, taltobulin, combretastatin.A.4",0.166215625343521,0.0579919469776868,FALSE
+"H2009","Pearson.est","tyrosine kinase inhibitor",0.2291,0.67,0.896,213,0.936,"mubritinib, PP.121, sorafenib, GTP.14564, dasatinib, UNC2250",0.0476919903378748,0.0287241512618947,FALSE
+"H2009","Pearson.est","VEGFR inhibitor",0.33574,0.957,0.431,191,0.908,"axitinib, lenvatinib, linifanib, sorafenib, dovitinib, semaxanib, SU014813, ZM.306416, pazopanib, ENMD.2076",0.365522729839268,0.0419141514789149,FALSE
+"H2009","Pearson.est","vitamin D receptor agonist",-0.30587,-0.753,0.782,1422,0.904,"ercalcitriol",0.106793246940152,0.0438315695246367,FALSE
+"H2126","Pearson.est","EGFR inhibitor",-0.46085,-1.16,0.291,1176,0.629,"rociletinib, poziotinib, tucatinib, CNX.2006, BIBX.1382, GW.583340, BMS.599626, vandetanib, CGP.52411, dacomitinib, BIBU.1361, pelitinib, PD.168393, PD.153035, OSI.420, AST.1306, CP.724714, WZ8040",0.536107011014093,0.201349354554731,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",0.32019,0.832,0.624,351,0.836,"GZD824, bafetinib, ponatinib, nilotinib, KW.2449, dasatinib",0.204815410317576,0.0777937225609836,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",-0.30475,-0.779,0.73,1400,0.852,"oxiracetam",0.136677139879544,0.0695604052332999,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",-0.53802,-1.38,0.149,959,0.609,"methscopolamine, darifenacin, diphemanil, dicycloverine",0.826813731587726,0.215382707367125,FALSE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.63133,-1.6,0.0505,1320,0.575,"MRS.1220, CGS.15943, istradefylline",1.29670862188134,0.24033215531037,FALSE
+"H2126","Pearson.est","adrenergic receptor agonist",0.37514,0.994,0.427,277,0.745,"epinephrine, norepinephrine, terbutaline, buphenine, clenbuterol, ritodrine",0.369572124974976,0.127843727251707,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",-0.30502,-0.79,0.696,1091,0.882,"RS.17053, prazosin, atenolol...., pindolol, imiloxan, dronedarone",0.157390760389438,0.0545314148681803,FALSE
+"H2126","Pearson.est","AKT inhibitor",-0.40204,-1.03,0.42,1293,0.722,"CCT128930, A.674563, AT7867",0.3767507096021,0.141462802430361,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.53668,1.43,0.107,367,0.508,"brigatinib, alectinib, DMH1, CEP.37440, crizotinib, lorlatinib, SB.505124",0.97061622231479,0.294136287716081,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",-0.59537,-1.51,0.0893,914,0.595,"nilutamide, flutamide, cyproterone.acetate, enzalutamide, RU.58841",1.04914854111145,0.22548303427145,FALSE
+"H2126","Pearson.est","antioxidant",-0.52701,-1.33,0.175,1017,0.606,"taurine, trolox, benfotiamine",0.756961951313706,0.217527375833714,FALSE
+"H2126","Pearson.est","AP inhibitor",-0.5653,-1.46,0.0958,1308,0.552,"embelin, tanshinone.i",1.01863449092146,0.258060922270801,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.44028,1.16,0.289,313,0.719,"digitoxigenin, digitoxin, oligomycin.a, rabeprazole, NMS.873, ouabain",0.539102157243452,0.143271109617117,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.37737,1.01,0.441,431,0.745,"CCT137690, AMG900, MK.8745, barasertib, KW.2449, PF.03814735, danusertib, GSK1070916, MK.5108, ENMD.2076, barasertib.HQPA",0.355561410532161,0.127843727251707,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.34088,-0.855,0.599,1288,0.878,"valnemulin, tilmicosin",0.222573177610689,0.0565054840938974,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.33241,0.89,0.572,263,0.819,"sparfloxacin, finafloxacin, lomefloxacin",0.242603971206976,0.0867160982395816,FALSE
+"H2126","Pearson.est","BCL inhibitor",-0.24512,-0.62,0.915,1380,0.901,"obatoclax",0.0385789059335517,0.045275209020937,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.41554,1.09,0.351,222,0.733,"GZD824, bafetinib, ponatinib, nilotinib",0.454692883534176,0.134896025358872,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",0.34471,0.894,0.563,147,0.843,"bentazepam, piperazine, ZK.93423",0.249491605148654,0.0741724253752577,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",-0.50317,-1.29,0.209,936,0.644,"I.BET151, I.BET.762, bromosporine",0.679853713888946,0.191114132640188,FALSE
+"H2126","Pearson.est","calcium channel blocker",-0.45827,-1.18,0.292,1143,0.625,"SKF.96365, tetrandrine, SR.33805, cinnarazine, mibefradil",0.534617148551582,0.204119982655925,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.73018,1.88,0.0155,37,0.239,"UNBS.5162, ZK811752",1.80966830182971,0.621602099051862,TRUE
+"H2126","Pearson.est","CDK inhibitor",-0.44611,-1.11,0.34,1191,0.633,"kenpaullone, dinaciclib, arcyriaflavin.a, ribociclib, AT.7519, CR8..R., TG.02, indirubin",0.468521082957745,0.198596289982645,FALSE
+"H2126","Pearson.est","CHK inhibitor",-0.42298,-1.08,0.367,1216,0.658,"AZD7762, CHIR.124",0.435333935747911,0.181774106386044,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.32954,-0.841,0.643,1314,0.849,"FR.122047, phenylbutazone, naproxen, tryptanthrin",0.191789027075778,0.0710923097560473,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",-0.37239,-0.958,0.478,1435,0.799,"itraconazole",0.320572103387881,0.0974532206860086,FALSE
+"H2126","Pearson.est","DNA alkylating agent",0.28984,0.767,0.742,476,0.917,"dianhydrogalactitol, carboplatin, carmustine, melphalan, mitomycin.c, cyclophosphamide, estramustine",0.129596094720973,0.0376306643299789,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.3933,1.04,0.397,287,0.721,"teroxirone, chlorambucil, carboplatin, mechlorethamine, carmustine, melphalan, tirapazamine",0.401209493236885,0.142064735280571,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",0.40835,1.05,0.362,226,0.736,"SGI.1027, decitabine",0.441291429466834,0.133122185662501,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",-0.32802,-0.845,0.626,1271,0.867,"adefovir.dipivoxil, cidofovir",0.20342566678957,0.0619809025237897,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",-0.28007,-0.704,0.8,1145,0.87,"estramustine.phosphate, cisplatin, anisomycin, altretamine",0.0969100130080564,0.0604807473813815,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.44618,-1.18,0.272,1175,0.625,"clebopride, oxiperomide, acetophenazine, piperacetazine, nemonapride, remoxipride",0.565431095965801,0.204119982655925,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",-0.25919,-0.675,0.845,1173,0.864,"equol, PPT",0.0731432910503077,0.0634862575211067,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",-0.33359,-0.879,0.573,1383,0.892,"tamoxifen",0.24184537803261,0.0496351456238769,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.44361,1.2,0.217,82,0.802,"erdafitinib, dovitinib, regorafenib",0.66354026615147,0.0958256317158365,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.28893,0.754,0.745,316,0.909,"dovitinib, tyrphostin.AG.1296, ponatinib, sorafenib, tandutinib, KW.2449, gilteritinib",0.127843727251707,0.0414361167780325,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",0.32333,0.865,0.578,497,0.835,"fluticasone.propionate, ciclesonide, prednisolone, flumethasone.pivalate, prednisolone.hemisuccinate, fluocinolone.acetonide, triamcinolone, halobetasol.propionate, betamethasone, desonide, triamcinolone.acetonide, clobetasol.propionate, prednisolone.acetate, fludroxycortide, beclomethasone.dipropionate, halcinonide",0.238072161579471,0.0783135245163979,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.30456,-0.77,0.72,1353,0.843,"latrepirdine, CPP",0.142667503568732,0.0741724253752577,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.5508,-1.43,0.111,1029,0.557,"CHIR.98014, AZD2858, kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin",0.954677021213343,0.254144804826271,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.56368,1.48,0.0899,76,0.545,"PHA.848125, GSK1838705A",1.04624030826677,0.263603497723358,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.37343,0.988,0.453,244,0.726,"narlaprevir, daclatasvir, mericitabine",0.343901797987168,0.139063379299906,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.62682,-1.59,0.0478,1024,0.482,"givinostat, AR.42, dacinostat, RGFP966, resminostat, ACY.1215, vorinostat, tacedinaline, panobinostat, PCI.24781, R306465, M.344, RG2833, entinostat, mocetinostat, SB.939, scriptaid, romidepsin, JNJ.26481585",1.32057210338788,0.31695296176115,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",-0.44722,-1.15,0.298,1092,0.616,"astemizole, tiotidine, levocetirizine, ranitidine, epinastine, famotidine, BF2.649, tecastemizole, chloropyramine",0.525783735923745,0.210419287835575,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",-0.32004,-0.798,0.693,901,0.895,"lovastatin, simvastatin, mevastatin",0.159266765388193,0.048176964684088,FALSE
+"H2126","Pearson.est","HSP inhibitor",-0.35052,-0.885,0.558,1165,0.912,"alvespimycin, XL888, tanespimycin, KW.2478, VER.49009",0.253365801062421,0.0400051616715838,FALSE
+"H2126","Pearson.est","JAK inhibitor",-0.3005,-0.763,0.738,1404,0.831,"TG.02, pacritinib",0.131943638176958,0.080398976215889,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.2613,0.683,0.829,252,0.905,"regorafenib, OSI.930, masitinib, sorafenib, tandutinib",0.0814454694497265,0.0433514207947967,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.50166,-1.28,0.202,1025,0.62,"nutlin.3, idasanutlin, AMG.232, CGM097, RITA",0.694648630553376,0.207608310501746,FALSE
+"H2126","Pearson.est","MEK inhibitor",-0.3391,-0.869,0.584,1254,0.88,"TAK.733, selumetinib, BIX.02188, nobiletin",0.233587152887601,0.0555173278498314,FALSE
+"H2126","Pearson.est","MET inhibitor",0.4158,1.08,0.337,89,0.713,"LY2801653",0.472370099128661,0.146910470148134,FALSE
+"H2126","Pearson.est","microtubule inhibitor",-0.2834,-0.735,0.771,1145,0.85,"estramustine.phosphate, triclabendazole, colchicine, cytochalasin.b",0.112945621949043,0.0705810742857073,FALSE
+"H2126","Pearson.est","mTOR inhibitor",0.40679,1.1,0.339,266,0.754,"ku.0063794, PP242, AZD2014, PI.103, SB.2343, MLN0128, WYE.125132, OSI.027",0.469800301796918,0.122628654130226,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.46538,-1.21,0.251,1051,0.683,"betulinic.acid, bortezomib, BAY.11.7085, IKK.2.inhibitor.V, tyloxapol, Ro.106.9920, parthenolide",0.600326278518962,0.165579296318467,FALSE
+"H2126","Pearson.est","opioid receptor agonist",-0.37593,-0.96,0.482,1179,0.826,"salvinorin.a, cebranopadol, ADL5859",0.31695296176115,0.0830199526796178,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",0.43413,1.14,0.293,427,0.713,"talmapimod, CMPD.1, SB.239063, skepinone.l",0.533132379645891,0.146910470148134,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.44848,1.19,0.253,319,0.705,"olaparib, AZD2461, talazoparib, PJ.34, niraparib",0.596879478824182,0.151810883008601,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.2839,0.738,0.757,170,0.879,"dovitinib, regorafenib, ponatinib, masitinib, sorafenib",0.120904120499927,0.0560111249262281,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",0.25329,0.674,0.875,49,0.892,"sodium.stibogluconate",0.0579919469776868,0.0496351456238769,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",-0.30276,-0.782,0.712,1276,0.871,"avanafil, anagrelide",0.147520006363144,0.0599818449923368,FALSE
+"H2126","Pearson.est","PI3K inhibitor",0.27009,0.697,0.798,486,0.911,"buparlisib, PI.103, SB.2343, CH5132799, PI3K.IN.2, GDC.0980, GDC.0941, BGT226, NVP.BEZ235, ZSTK.474, idelalisib, PKI.179, PF.04691502, alpelisib",0.0979971086492706,0.0404816230270017,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.81496,2.16,0,177,0.0358,"GW.843682X, HMN.214, volasertib, NMS.1286937, GSK461364, BI.2536",Inf,1.44611697335613,TRUE
+"H2126","Pearson.est","potassium channel blocker",-0.70184,-1.82,0.015,1044,0.298,"dofetilide, oleoylethanolamide, ibutilide, ML133, mepivacaine",1.82390874094432,0.525783735923745,FALSE
+"H2126","Pearson.est","PPAR receptor agonist",-0.52648,-1.36,0.157,996,0.596,"fenofibrate, pterostilbene, oleoylethanolamide, clofibrate, S26948, GW.501516",0.804100347590766,0.224753740259764,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",0.31993,0.837,0.638,282,0.856,"nomegestrol.acetate, melengestrol.acetate",0.195179321278838,0.0675262353228468,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.59609,1.59,0.0681,81,0.417,"MG.132, delanzomib",1.16685288808721,0.379863945026242,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.36333,0.966,0.479,406,0.737,"clofoctol, cycloheximide, chloramphenicol.palmitate, thiostrepton, mercaptopurine, puromycin, methacycline",0.319664486585437,0.132532512140949,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.48308,-1.21,0.245,1070,0.683,"rheochrysidin, AV.412, BMS.599626, CP.724714",0.610833915635468,0.165579296318467,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.48312,1.24,0.22,326,0.773,"RAF265, SB.590885, regorafenib, sorafenib, vemurafenib, PLX.4720",0.657577319177794,0.111820506081675,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.48254,1.29,0.176,170,0.734,"regorafenib, sorafenib",0.75448733218585,0.134303940083929,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.67349,1.78,0.0219,230,0.243,"adapalene, tamibarotene, LE.135",1.65955588515988,0.614393726401688,TRUE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.54411,1.46,0.114,291,0.514,"hydroxyurea, cladribine, cytarabine, triapine, fludarabine.phosphate",0.943095148663527,0.289036881004724,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",-0.76611,-2,0.00738,1447,0.135,"aripiprazole",2.13194363817696,0.869666231504994,TRUE
+"H2126","Pearson.est","serotonin receptor antagonist",-0.43681,-1.13,0.316,1447,0.624,"aripiprazole",0.500312917381596,0.204815410317576,FALSE
+"H2126","Pearson.est","sodium channel blocker",0.28691,0.752,0.725,88,0.884,"brivaracetam, benzocaine",0.139661993429006,0.0535477349869269,FALSE
+"H2126","Pearson.est","src inhibitor",-0.46277,-1.19,0.26,1076,0.677,"PP.1, TG.100572, bosutinib, PP.2, ZM.306416",0.585026652029182,0.169411331314856,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.69175,1.84,0.0249,166,0.213,"chlormidazole, lanoconazole, sulconazole",1.60380065290426,0.671620396561262,TRUE
+"H2126","Pearson.est","TGF beta receptor inhibitor",-0.71089,-1.8,0.00722,1385,0.233,"SB.431542, SB.525334, repsox",2.14146280243036,0.632644078973981,TRUE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.23133,0.597,0.908,398,0.948,"raltitrexed, ftorafur, trifluridine",0.0419141514789149,0.0231916626619338,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.65131,1.7,0.0523,420,0.308,"mitoxantrone, topotecan, amsacrine, etoposide.phosphate, doxorubicin, exatecan.mesylate, idarubicin, dexrazoxane, genz.644282, TAS.103, epirubicin, nemorubicin, etoposide, voreloxin, rubitecan, SN.38, daunorubicin, beta.lapachone, amonafide, irinotecan, valrubicin",1.28149831113273,0.511449283499556,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.46017,1.19,0.253,549,0.705,"BNC105, mebendazole, taltobulin, verubulin, vinblastine, fenbendazole, oxibendazole, albendazole, podophyllotoxin, flubendazole, indibulin, paclitaxel, vinorelbine, dolastatin.10, ABT.751, epothilone.b, vindesine, vincristine, docetaxel",0.596879478824182,0.151810883008601,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",-0.26691,-0.683,0.833,1070,0.874,"rheochrysidin, tyrphostin.AG.99, UNC2250, AV.412, AMG.208, BMS.599626, vandetanib, GTP.14564, CP.724714",0.0793549985932124,0.058488567365597,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",0.21094,0.555,0.952,206,0.952,"RAF265, dovitinib, regorafenib, OSI.930, tivozanib, sorafenib, foretinib",0.0213630516155257,0.0213630516155257,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.5807,-1.48,0.0934,1222,0.578,"alfacalcidol, tacalcitol, paricalcitol",1.02965312376991,0.238072161579471,FALSE
+"H3255","Pearson.est","EGFR inhibitor",-0.51478,-1.27,0.21,1073,0.534,"GW.583340, XL.647, BMS.690514, CP.724714, tucatinib, vandetanib, tyrphostin.AG.1478, BMS.599626, gefitinib, AEE788, neratinib, TAK.285, lapatinib, PD.168393, WZ8040, PD.153035, OSI.420, canertinib, icotinib, afatinib, pelitinib, osimertinib, BIBU.1361, erlotinib",0.677780705266081,0.272458742971444,FALSE
+"H3255","Pearson.est","Abl kinase inhibitor",0.2923,0.746,0.739,286,0.898,"ponatinib, dasatinib, flumatinib, GZD824, ZM.306416",0.131355561605174,0.0467236633326956,FALSE
+"H3255","Pearson.est","acetylcholine receptor agonist",0.46189,1.22,0.252,168,1,"xanomeline, nicotine",0.598599459218456,0,FALSE
+"H3255","Pearson.est","acetylcholine receptor antagonist",-0.25234,-0.644,0.883,1379,0.961,"diphemanil",0.0540392964224314,0.0172766123314547,FALSE
+"H3255","Pearson.est","adenosine receptor antagonist",-0.46757,-1.15,0.304,997,0.654,"PSB.1115, SCH.58261, MRS.1220, CGS.15943",0.517126416391246,0.184422251675733,FALSE
+"H3255","Pearson.est","adrenergic receptor agonist",-0.20926,-0.53,0.964,1027,0.968,"A61603, isoxsuprine, clenbuterol, oxymetazoline, epinephrine",0.0159229660971692,0.0141246426916063,FALSE
+"H3255","Pearson.est","adrenergic receptor antagonist",-0.32136,-0.803,0.708,1206,0.936,"pindolol, RS.17053, vincamine, levobunolol, carvedilol, dronedarone",0.149966742310231,0.0287241512618947,FALSE
+"H3255","Pearson.est","AKT inhibitor",-0.43141,-1.07,0.374,1094,0.73,"GDC.0068, uprosertib, CCT128930, triciribine, palomid.529",0.42712839779952,0.136677139879544,FALSE
+"H3255","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.36462,-0.903,0.568,1142,0.904,"CEP.37440, AZD3463, NVP.TAE684",0.245651664288981,0.0438315695246367,FALSE
+"H3255","Pearson.est","androgen receptor antagonist",0.343,0.918,0.527,243,0.891,"RU.58841, enzalutamide",0.278189384787453,0.0501222959631252,FALSE
+"H3255","Pearson.est","antioxidant",0.45576,1.2,0.237,18,0.976,"trolox",0.625251653989896,0.0105501823333082,FALSE
+"H3255","Pearson.est","AP inhibitor",-0.43916,-1.09,0.374,1182,0.719,"tanshinone.i, GDC.0152, LCL.161",0.42712839779952,0.143271109617117,FALSE
+"H3255","Pearson.est","ATPase inhibitor",0.63251,1.69,0.045,293,0.658,"k.strophanthidin, oligomycin.a, evodiamine, digoxin, NMS.873, blebbistatin....",1.34678748622466,0.181774106386044,FALSE
+"H3255","Pearson.est","Aurora kinase inhibitor",0.39087,1,0.426,324,0.915,"AT.9283, CYC116, barasertib.HQPA, SNS.314, CCT129202, TAK.901, aurora.a.inhibitor.i, barasertib, ENMD.2076",0.370590400897281,0.0385789059335517,FALSE
+"H3255","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.3125,0.844,0.628,258,1,"josamycin, radezolid, valnemulin, tilmicosin",0.202040356262804,0,FALSE
+"H3255","Pearson.est","bacterial DNA gyrase inhibitor",-0.22987,-0.577,0.933,1024,0.979,"novobiocin, sarafloxacin, trovafloxacin",0.0301183562535,0.00921730819686218,FALSE
+"H3255","Pearson.est","BCL inhibitor",0.3904,1.04,0.376,389,0.878,"ABT.737, gossypol, TW.37, obatoclax, venetoclax",0.424812155072339,0.0565054840938974,FALSE
+"H3255","Pearson.est","Bcr.Abl kinase inhibitor",0.30297,0.795,0.678,223,1,"ponatinib, dasatinib, flumatinib, GZD824",0.168770306132937,0,FALSE
+"H3255","Pearson.est","benzodiazepine receptor agonist",-0.33509,-0.841,0.677,897,0.945,"indiplon, bentazepam, CGS.20625, ZK.93423, zaleplon",0.169411331314856,0.0245681914907371,FALSE
+"H3255","Pearson.est","bromodomain inhibitor",-0.4036,-0.997,0.451,1203,0.744,"JQ1....",0.345823458122039,0.128427064454121,FALSE
+"H3255","Pearson.est","calcium channel blocker",0.29499,0.783,0.714,291,0.947,"efonidipine.monoethanolate, carboxyamidotriazole, SR.33805",0.146301788223826,0.0236500209967266,FALSE
+"H3255","Pearson.est","CC chemokine receptor antagonist",-0.27838,-0.71,0.796,1413,0.944,"navarixin",0.0990869322623309,0.025028005701931,FALSE
+"H3255","Pearson.est","CDK inhibitor",-0.40192,-1.01,0.419,1185,0.745,"PHA.793887, BMS.387032, AZD5438, kenpaullone, alvocidib, arcyriaflavin.a",0.377785977033705,0.127843727251707,FALSE
+"H3255","Pearson.est","CHK inhibitor",-0.52259,-1.32,0.132,968,0.497,"CHIR.124, SCH.900776, LY2606368, LY2603618",0.87942606879415,0.303643611266668,FALSE
+"H3255","Pearson.est","cyclooxygenase inhibitor",-0.26442,-0.655,0.858,868,0.991,"curcumin, amfenac, acetylsalicylsalicylic.acid, aspirin, meloxicam, FR.122047, suxibuzone, indoprofen, ramifenazone, AM.404, FK.3311",0.0665127121512946,0.00392634551472468,FALSE
+"H3255","Pearson.est","cytochrome P450 inhibitor",0.46194,1.25,0.205,358,1,"metyrapone, eplerenone, itraconazole, morin",0.688246138944246,0,FALSE
+"H3255","Pearson.est","DNA alkylating agent",-0.41616,-1.03,0.433,1307,0.785,"mitomycin.c, ifosfamide, melphalan, dacarbazine",0.363512103646635,0.105130343254747,FALSE
+"H3255","Pearson.est","DNA inhibitor",-0.26495,-0.654,0.89,1014,0.97,"valrubicin, sangivamycin, bendamustine, nithiamide, busulfan, primaquine, melphalan",0.0506099933550872,0.0132282657337552,FALSE
+"H3255","Pearson.est","DNA methyltransferase inhibitor",-0.7504,-1.9,0.0085,1344,0.248,"SGI.1027, fdcyd, azacitidine",2.07058107428571,0.605548319173784,TRUE
+"H3255","Pearson.est","DNA polymerase inhibitor",0.28615,0.756,0.716,360,0.917,"famciclovir, adefovir.dipivoxil, foscarnet",0.145086977692144,0.0376306643299789,FALSE
+"H3255","Pearson.est","DNA synthesis inhibitor",-0.34415,-0.871,0.58,949,0.914,"capecitabine, enocitabine, cyclocytidine, estramustine.phosphate, anisomycin, altretamine, mitomycin.c, floxuridine",0.236572006437063,0.0390538042661686,FALSE
+"H3255","Pearson.est","dopamine receptor antagonist",0.24463,0.653,0.872,270,0.963,"thioproperazine, remoxipride, clebopride, domperidone, nemonapride, raclopride",0.0594835150674328,0.0163737128754655,FALSE
+"H3255","Pearson.est","estrogen receptor agonist",0.4263,1.13,0.296,406,0.875,"estrone, erteberel, levonorgestrel, estradiol.cypionate, ethinyl.estradiol",0.528708288941061,0.0579919469776868,FALSE
+"H3255","Pearson.est","estrogen receptor antagonist",0.39171,1.04,0.405,107,0.878,"tamoxifen",0.392544976785331,0.0565054840938974,FALSE
+"H3255","Pearson.est","FGFR inhibitor",0.34743,0.932,0.531,253,0.962,"erdafitinib, nintedanib, AZD4547, lenvatinib",0.274905478918531,0.0168249279621871,FALSE
+"H3255","Pearson.est","FLT3 inhibitor",0.2219,0.594,0.918,370,0.99,"tyrphostin.AG.1296, ponatinib, GTP.14564, TG.101348, ENMD.2076, gilteritinib",0.0371573187987575,0.00436480540245009,FALSE
+"H3255","Pearson.est","glucocorticoid receptor agonist",0.61621,1.65,0.0463,91,0.529,"hydrocortisone, beclomethasone.dipropionate, dexamethasone.acetate, triamcinolone, desonide, fluticasone.propionate, halcinonide, piretanide",1.33441900898205,0.276544327964814,FALSE
+"H3255","Pearson.est","glutamate receptor antagonist",-0.49291,-1.22,0.246,1313,0.601,"diazooxonorleucine, MTPG, ACDPP",0.609064892896621,0.22112552799726,FALSE
+"H3255","Pearson.est","glycogen synthase kinase inhibitor",-0.55557,-1.38,0.13,1202,0.554,"GSK.3.inhibitor.IX, LY2090314, kenpaullone, AZD2858",0.886056647693163,0.25649023527157,FALSE
+"H3255","Pearson.est","growth factor receptor inhibitor",-0.36284,-0.892,0.579,1017,0.898,"GSK1838705A, AZD3463, GW.441756",0.237321436272564,0.0467236633326956,FALSE
+"H3255","Pearson.est","HCV inhibitor",-0.56102,-1.4,0.125,1321,0.61,"PSI.7976, daclatasvir",0.903089986991944,0.214670164989233,FALSE
+"H3255","Pearson.est","HDAC inhibitor",-0.57408,-1.44,0.109,1114,1,"AR.42, vorinostat, M.344, givinostat, nexturastat.a, chidamide, entinostat, romidepsin, tacedinaline, PCI.24781, R306465, panobinostat, JNJ.26481585, SB.939",0.962573502059376,0,FALSE
+"H3255","Pearson.est","histamine receptor antagonist",-0.57235,-1.43,0.122,1156,0.89,"levocetirizine, astemizole, ranitidine, terfenadine, tecastemizole, cyproheptadine, chloropyramine, zolantidine",0.913640169325252,0.0506099933550872,FALSE
+"H3255","Pearson.est","HMGCR inhibitor",0.30595,0.825,0.624,296,0.993,"lovastatin, atorvastatin",0.204815410317576,0.00305075150461883,FALSE
+"H3255","Pearson.est","HSP inhibitor",-0.55124,-1.36,0.161,1010,0.555,"VER.49009, BIIB021, SNX.2112, PU.H71, NVP.AUY922, tanespimycin, alvespimycin, SNX.5422, XL888",0.79317412396815,0.255707016877324,FALSE
+"H3255","Pearson.est","JAK inhibitor",0.2023,0.529,0.975,74,0.97,"AT.9283, filgotinib",0.0109953843014632,0.0132282657337552,FALSE
+"H3255","Pearson.est","KIT inhibitor",-0.31777,-0.792,0.691,860,0.909,"sunitinib, imatinib, motesanib, vatalanib, OSI.930, regorafenib, telatinib, tandutinib",0.160521952625802,0.0414361167780325,FALSE
+"H3255","Pearson.est","MDM inhibitor",0.28387,0.773,0.745,66,0.925,"AMG.232",0.127843727251707,0.0338582672609674,FALSE
+"H3255","Pearson.est","MEK inhibitor",0.29911,0.793,0.702,134,0.969,"PD.318088, MEK1.2.inhibitor, refametinib",0.153662887870195,0.0136762229492347,FALSE
+"H3255","Pearson.est","MET inhibitor",-0.5637,-1.39,0.14,1013,0.581,"NVP.BVU972, AMG458, INC.280",0.853871964321762,0.235823867609669,FALSE
+"H3255","Pearson.est","microtubule inhibitor",-0.32808,-0.823,0.69,935,0.951,"cabazitaxel, vinflunine, estramustine.phosphate, D.64131, podophyllotoxin",0.161150909262745,0.0218194830625861,FALSE
+"H3255","Pearson.est","mTOR inhibitor",0.35704,0.936,0.509,318,1,"torin.1, OSI.027, WYE.354, SB.2343, PF.04691502, WYE.125132, AZD2014, PKI.179, XL388, LY3023414, voxtalisib, MLN0128",0.293282217663241,0,FALSE
+"H3255","Pearson.est","NFkB pathway inhibitor",0.44904,1.18,0.239,59,0.829,"EVP4593, tyloxapol",0.621602099051862,0.0814454694497265,FALSE
+"H3255","Pearson.est","opioid receptor agonist",-0.46758,-1.16,0.273,1409,0.693,"salvinorin.a",0.563837352959244,0.159266765388193,FALSE
+"H3255","Pearson.est","p38 MAPK inhibitor",-0.55788,-1.41,0.112,1058,0.73,"TAK.715, SB.239063, VX.702, CMPD.1",0.950781977329818,0.136677139879544,FALSE
+"H3255","Pearson.est","PARP inhibitor",-0.59878,-1.52,0.0675,1216,0.865,"talazoparib, olaparib, niraparib, PJ.34",1.17069622716898,0.0629838925351858,FALSE
+"H3255","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.21319,0.554,0.97,253,0.987,"nintedanib, linifanib, axitinib, ponatinib, dasatinib, lenvatinib",0.0132282657337552,0.00568284733036327,FALSE
+"H3255","Pearson.est","phosphatase inhibitor",-0.25989,-0.643,0.877,1108,0.942,"mycophenolate.mofetil, AS.1949490, sodium.stibogluconate",0.0570004066339595,0.0259490972071227,FALSE
+"H3255","Pearson.est","phosphodiesterase inhibitor",-0.54754,-1.35,0.143,1074,0.536,"trequinsin, GSK256066, EMD.53998, papaverine, YM.976, zardaverine, cilostamide",0.844663962534938,0.27083521030723,FALSE
+"H3255","Pearson.est","PI3K inhibitor",0.27867,0.719,0.768,313,0.907,"GDC.0941, SB.2343, PF.04691502, ZSTK.474, buparlisib, PKI.179, LY3023414, voxtalisib",0.114638779968488,0.0423927129399047,FALSE
+"H3255","Pearson.est","PLK inhibitor",-0.57657,-1.4,0.121,1011,0.61,"HMN.214, GSK461364, BI.2536",0.91721462968355,0.214670164989233,FALSE
+"H3255","Pearson.est","potassium channel blocker",-0.40357,-1.01,0.453,1175,0.745,"meglitinide, oleoylethanolamide",0.343901797987168,0.127843727251707,FALSE
+"H3255","Pearson.est","PPAR receptor agonist",0.44848,1.23,0.208,34,1,"fenofibrate, clofibrate",0.681936665037238,0,FALSE
+"H3255","Pearson.est","progesterone receptor agonist",0.63677,1.76,0.0338,248,0.957,"tanaproget, norethindrone, nomegestrol.acetate, norgestrel",1.47108329972235,0.0190880622231565,FALSE
+"H3255","Pearson.est","proteasome inhibitor",-0.69441,-1.75,0.013,1057,0.404,"MG.132, ONX.0914, carfilzomib, delanzomib, bortezomib, ixazomib, ixazomib.citrate",1.88605664769316,0.393618634889395,FALSE
+"H3255","Pearson.est","protein synthesis inhibitor",-0.28992,-0.715,0.821,1124,0.959,"brefeldin.a, puromycin, homoharringtonine, azomycin..2.nitroimidazole., emetine",0.0856568428805592,0.0181813928293364,FALSE
+"H3255","Pearson.est","protein tyrosine kinase inhibitor",0.35105,0.918,0.538,113,0.891,"mubritinib, PP.121",0.269217724333611,0.0501222959631252,FALSE
+"H3255","Pearson.est","RAF inhibitor",-0.53213,-1.32,0.18,1076,0.497,"regorafenib, SB.590885, vemurafenib, LGX818, dabrafenib, CEP.32496, GDC.0879",0.744727494896694,0.303643611266668,FALSE
+"H3255","Pearson.est","RET tyrosine kinase inhibitor",-0.52575,-1.29,0.194,1076,0.524,"regorafenib, vandetanib, apatinib",0.712198270069774,0.280668713016273,FALSE
+"H3255","Pearson.est","retinoid receptor agonist",-0.56665,-1.42,0.096,1235,0.797,"tamibarotene, adarotene, AM.580, CD.437",1.01772876696043,0.0985416786038876,FALSE
+"H3255","Pearson.est","ribonucleotide reductase inhibitor",-0.41084,-1.02,0.409,1132,0.777,"gemcitabine, fludarabine.phosphate, clofarabine, fludarabine",0.388276691992658,0.109578981199086,FALSE
+"H3255","Pearson.est","serotonin receptor agonist",0.45599,1.19,0.259,133,0.894,"zolmitriptan, aripiprazole",0.586700235918748,0.0486624812040823,FALSE
+"H3255","Pearson.est","serotonin receptor antagonist",-0.32401,-0.812,0.679,1077,0.945,"RS.16566, sertindole, ziprasidone, SB.228357",0.168130225719498,0.0245681914907371,FALSE
+"H3255","Pearson.est","sodium channel blocker",0.41085,1.09,0.326,84,0.895,"oxcarbazepine, benzethonium, cibenzoline",0.486782399932061,0.048176964684088,FALSE
+"H3255","Pearson.est","src inhibitor",-0.28932,-0.739,0.774,950,0.946,"PP.2, TG.100572, saracatinib, KX2.391",0.111259039317107,0.0241088635982073,FALSE
+"H3255","Pearson.est","sterol demethylase inhibitor",0.62176,1.64,0.064,105,0.412,"sulconazole, posaconazole, terconazole",1.19382002601611,0.385102783966865,FALSE
+"H3255","Pearson.est","TGF beta receptor inhibitor",-0.32393,-0.801,0.717,1160,0.916,"D.4476, LY2109761",0.1444808443322,0.0381045263321496,FALSE
+"H3255","Pearson.est","thymidylate synthase inhibitor",-0.69308,-1.72,0.0149,1324,0.347,"carmofur, raltitrexed, doxifluridine",1.82681373158773,0.459670525209126,FALSE
+"H3255","Pearson.est","topoisomerase inhibitor",-0.53436,-1.33,0.161,1220,0.543,"topotecan, nemorubicin, licochalcone.a, irinotecan, rubitecan, SN.38, camptothecin, genz.644282, exatecan.mesylate",0.79317412396815,0.265200170411153,FALSE
+"H3255","Pearson.est","tubulin polymerization inhibitor",-0.45552,-1.15,0.285,805,0.654,"oxibendazole, ABT.751, indibulin, flubendazole, BNC105, epothilone.b, CYT.997, vinorelbine, dolastatin.10, vincristine, parbendazole, albendazole, plinabulin, mebendazole, fosbretabulin, KX2.391, podophyllotoxin, taltobulin, combretastatin.A.4",0.54515513999149,0.184422251675733,FALSE
+"H3255","Pearson.est","tyrosine kinase inhibitor",-0.30393,-0.757,0.77,1135,0.941,"CP.724714, AV.412, tyrphostin.A9, vandetanib, tivantinib, BMS.599626, apatinib, AMG.208, bafetinib",0.113509274827518,0.0264103765727431,FALSE
+"H3255","Pearson.est","VEGFR inhibitor",-0.21744,-0.545,0.964,946,0.979,"motesanib, foretinib, vatalanib, RAF265, OSI.930, regorafenib, XL.647, TG.100572, BMS.690514, telatinib, golvatinib, MGCD.265, vandetanib, lucitanib, AEE788, orantinib",0.0159229660971692,0.00921730819686218,FALSE
+"H3255","Pearson.est","vitamin D receptor agonist",-0.44314,-1.11,0.316,1198,0.706,"maxacalcitol, calcitriol, ercalcitriol",0.500312917381596,0.151195298948196,FALSE
+"H358","Pearson.est","EGFR inhibitor",-0.51398,-1.3,0.196,1045,0.548,"PD.168393, CP.724714, BMS.690514, ARRY.334543, AEE788, OSI.420, vandetanib, tucatinib, BMS.599626, rociletinib, GW.583340, BIBU.1361, PD.153035, canertinib, erlotinib, dacomitinib, TAK.285, tyrphostin.AG.1478, icotinib, WZ8040, neratinib, lapatinib, gefitinib, osimertinib, pelitinib, afatinib",0.707743928643524,0.261219441515631,FALSE
+"H358","Pearson.est","Abl kinase inhibitor",0.22552,0.594,0.913,357,1,"ponatinib, ZM.306416, flumatinib, GZD824, dasatinib",0.039529222465701,0,FALSE
+"H358","Pearson.est","acetylcholine receptor agonist",0.56475,1.53,0.0916,367,0.641,"xanomeline, nefiracetam",1.03810452633215,0.193141970481183,FALSE
+"H358","Pearson.est","acetylcholine receptor antagonist",-0.4512,-1.14,0.298,1412,0.586,"dicycloverine",0.525783735923745,0.232102383981909,FALSE
+"H358","Pearson.est","adenosine receptor antagonist",-0.51285,-1.3,0.173,1071,0.548,"sulmazole, theophylline, CGS.15943",0.761953896871205,0.261219441515631,FALSE
+"H358","Pearson.est","adrenergic receptor agonist",-0.47938,-1.23,0.224,944,0.561,"midodrine, methyldopa, epinephrine, norepinephrine, oxymetazoline, metaraminol, terbutaline, clenbuterol, A61603, isoxsuprine",0.649751981665837,0.251037138743839,FALSE
+"H358","Pearson.est","adrenergic receptor antagonist",-0.34512,-0.87,0.624,1295,0.857,"pindolol, vincamine, levobunolol, dronedarone",0.204815410317576,0.0670191780768018,FALSE
+"H358","Pearson.est","AKT inhibitor",-0.47207,-1.18,0.249,1007,0.581,"GDC.0068, GSK2110183, CCT128930, ONC201, palomid.529, triciribine, uprosertib",0.603800652904264,0.235823867609669,FALSE
+"H358","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26444,0.708,0.804,1068,1,"alectinib, brigatinib, SB.505124, DMH1, AZD3463, lorlatinib, NVP.TAE684, AP26113, GW.788388, CEP.37440, crizotinib",0.0947439512515487,0,FALSE
+"H358","Pearson.est","androgen receptor antagonist",-0.28281,-0.727,0.807,760,0.957,"flutamide, enzalutamide, nilutamide, bicalutamide, cyproterone.acetate",0.0931264652779296,0.0190880622231565,FALSE
+"H358","Pearson.est","antioxidant",0.5127,1.39,0.135,14,0.696,"trolox",0.869666231504994,0.157390760389438,FALSE
+"H358","Pearson.est","AP inhibitor",-0.46805,-1.19,0.261,989,0.613,"GDC.0152, tanshinone.i, LCL.161, embelin",0.583359492661719,0.212539525481585,FALSE
+"H358","Pearson.est","ATPase inhibitor",0.70154,1.89,0.0148,83,0.151,"k.strophanthidin, NMS.873, oligomycin.a, blebbistatin....",1.82973828460504,0.821023052706831,TRUE
+"H358","Pearson.est","Aurora kinase inhibitor",0.21701,0.584,0.93,482,0.999,"CYC116, CCT129202, AT.9283, barasertib.HQPA, PHA.680632, ENMD.2076, CCT137690, TAK.901, GSK1070916, SNS.314, danusertib, KW.2449",0.0315170514460649,0.000434511774017692,FALSE
+"H358","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.29645,0.826,0.657,26,1,"radezolid",0.182434630440219,0,FALSE
+"H358","Pearson.est","bacterial DNA gyrase inhibitor",-0.35459,-0.87,0.62,1113,0.857,"sarafloxacin, lomefloxacin, sparfloxacin, trovafloxacin",0.207608310501746,0.0670191780768018,FALSE
+"H358","Pearson.est","BCL inhibitor",0.27847,0.753,0.741,1047,1,"gossypol, ABT.737, TW.37, venetoclax, HA14.1, oridonin, navitoclax, obatoclax",0.130181792020672,0,FALSE
+"H358","Pearson.est","Bcr.Abl kinase inhibitor",-0.20044,-0.503,0.979,1139,0.997,"metatinib, tozasertib, imatinib",0.00921730819686218,0.00130484168834428,FALSE
+"H358","Pearson.est","benzodiazepine receptor agonist",-0.25642,-0.647,0.895,803,1,"eprinomectin, ZK.93423, temazepam, CGS.20625, indiplon, zaleplon",0.048176964684088,0,FALSE
+"H358","Pearson.est","bromodomain inhibitor",-0.65874,-1.62,0.0381,1179,0.528,"bromosporine, I.BET151, JQ1...., I.BET.762",1.41907502432438,0.277366077466188,FALSE
+"H358","Pearson.est","calcium channel blocker",0.28589,0.775,0.715,308,1,"efonidipine.monoethanolate, carboxyamidotriazole, pranidipine, cinnarazine",0.145693958198919,0,FALSE
+"H358","Pearson.est","CC chemokine receptor antagonist",-0.30267,-0.759,0.748,1115,0.978,"PF.04136309, MK.0812, navarixin",0.126098402135539,0.00966114521239857,FALSE
+"H358","Pearson.est","CDK inhibitor",-0.38777,-0.98,0.453,1097,0.767,"AZD5438, dinaciclib, P276.00, BMS.387032, kenpaullone, PHA.793887, arcyriaflavin.a, alvocidib, CR8..R.",0.343901797987168,0.115204636051019,FALSE
+"H358","Pearson.est","CHK inhibitor",-0.55031,-1.39,0.126,793,0.656,"SB.218078, AZD7762, PF.477736, CHIR.124, LY2603618, SCH.900776, LY2606368",0.899629454882437,0.18309616062434,FALSE
+"H358","Pearson.est","cyclooxygenase inhibitor",0.20353,0.532,0.959,188,0.968,"pterostilbene, tepoxalin, phenylbutazone, sulfasalazine",0.0181813928293364,0.0141246426916063,FALSE
+"H358","Pearson.est","cytochrome P450 inhibitor",0.23441,0.627,0.903,339,1,"eplerenone, morin, PF.4981517",0.0443122496864942,0,FALSE
+"H358","Pearson.est","DNA alkylating agent",-0.57136,-1.45,0.0895,1128,0.632,"mitomycin.c, dianhydrogalactitol, ifosfamide, estramustine, satraplatin, cisplatin, melphalan, dacarbazine",1.04817696468409,0.199282921717615,FALSE
+"H358","Pearson.est","DNA inhibitor",0.29353,0.803,0.651,185,1,"carboplatin, oxaliplatin, mechlorethamine, metronidazole, teroxirone",0.186419011431808,0,FALSE
+"H358","Pearson.est","DNA methyltransferase inhibitor",-0.72291,-1.84,0.0111,1426,0.454,"fdcyd, azacitidine",1.95467702121334,0.342944147142896,FALSE
+"H358","Pearson.est","DNA polymerase inhibitor",-0.53429,-1.34,0.143,897,0.619,"adefovir.dipivoxil, cephalomannine, trifluridine, cidofovir",0.844663962534938,0.208309350979882,FALSE
+"H358","Pearson.est","DNA synthesis inhibitor",-0.2998,-0.752,0.779,1128,0.965,"mitomycin.c, floxuridine, altretamine, cisplatin",0.108462542327436,0.0154726866562074,FALSE
+"H358","Pearson.est","dopamine receptor antagonist",-0.23834,-0.59,0.936,1194,0.986,"amisulpride, sertindole, acetophenazine, isofloxythepin",0.0287241512618947,0.0061230850587888,FALSE
+"H358","Pearson.est","estrogen receptor agonist",-0.33789,-0.86,0.639,1174,0.852,"equol, estradiol, PPT",0.1944991418416,0.0695604052332999,FALSE
+"H358","Pearson.est","estrogen receptor antagonist",-0.28098,-0.696,0.816,1047,0.978,"toremifene, raloxifene",0.0883098412461389,0.00966114521239857,FALSE
+"H358","Pearson.est","FGFR inhibitor",0.42861,1.15,0.269,119,0.734,"AZD4547, nintedanib, erdafitinib",0.570247719997592,0.134303940083929,FALSE
+"H358","Pearson.est","FLT3 inhibitor",-0.21741,-0.546,0.963,1345,0.997,"tandutinib, pacritinib",0.0163737128754655,0.00130484168834428,FALSE
+"H358","Pearson.est","glucocorticoid receptor agonist",0.71496,1.92,0.00767,139,0.381,"hydrocortisone, beclomethasone.dipropionate, dexamethasone.acetate, desonide, triamcinolone.acetonide, halcinonide, flumethasone.pivalate, rimexolone, triamcinolone, fluticasone.propionate, ciclesonide, fluocinolone.acetonide, deflazacort, betamethasone, clobetasol.propionate",2.11520463605102,0.419075024324381,FALSE
+"H358","Pearson.est","glutamate receptor antagonist",-0.41884,-1.06,0.394,1336,0.642,"ACDPP, LY456236, diazooxonorleucine",0.404503778174426,0.192464971931147,FALSE
+"H358","Pearson.est","glycogen synthase kinase inhibitor",-0.55724,-1.39,0.123,1275,0.656,"kenpaullone, GSK.3.inhibitor.IX, AZD2858",0.910094888560602,0.18309616062434,FALSE
+"H358","Pearson.est","growth factor receptor inhibitor",0.42628,1.16,0.272,500,0.779,"PHA.848125, GSK1904529A, lestaurtinib, danusertib, GSK1838705A",0.565431095965801,0.108462542327436,FALSE
+"H358","Pearson.est","HCV inhibitor",-0.62047,-1.55,0.068,1221,0.444,"daclatasvir, PSI.7976, embelin, Ro.9187",1.16749108729376,0.35261702988538,FALSE
+"H358","Pearson.est","HDAC inhibitor",-0.48952,-1.27,0.195,1052,0.574,"dacinostat, trichostatin.a, givinostat, romidepsin, tacedinaline, M.344, entinostat, vorinostat, R306465, PCI.24781, panobinostat, SB.939, JNJ.26481585",0.709965388637482,0.241088107602027,FALSE
+"H358","Pearson.est","histamine receptor antagonist",-0.5457,-1.35,0.166,1020,0.701,"cimetidine, cyproheptadine, lafutidine, astemizole, tecastemizole, terfenadine, tiotidine, levocetirizine, zolantidine, chloropyramine",0.779891911959945,0.154281982033341,FALSE
+"H358","Pearson.est","HMGCR inhibitor",0.28127,0.747,0.769,374,1,"lovastatin, pitavastatin, atorvastatin",0.114073660198569,0,FALSE
+"H358","Pearson.est","HSP inhibitor",-0.47492,-1.18,0.281,845,0.581,"SNX.5422, ganetespib, SNX.2112, PU.H71, tanespimycin, KW.2478, guanidine, BIIB021, alvespimycin, XL888, NVP.AUY922, VER.49009",0.55129368009492,0.235823867609669,FALSE
+"H358","Pearson.est","JAK inhibitor",-0.34899,-0.878,0.597,1376,0.89,"pacritinib, LY2784544, atiprimod",0.224025668870631,0.0506099933550872,FALSE
+"H358","Pearson.est","KIT inhibitor",-0.33649,-0.852,0.658,1233,0.844,"imatinib, telatinib, tandutinib",0.181774106386044,0.073657553374345,FALSE
+"H358","Pearson.est","MDM inhibitor",0.71263,1.9,0.0131,416,0.214,"AMG.232, idasanutlin, nutlin.3, RITA, serdemetan",1.88272870434424,0.669586226650809,TRUE
+"H358","Pearson.est","MEK inhibitor",-0.3513,-0.888,0.571,1436,0.897,"nobiletin, BIX.02188",0.243363891754152,0.0472075569559079,FALSE
+"H358","Pearson.est","MET inhibitor",-0.71441,-1.78,0.0131,1126,0.369,"NVP.BVU972, LY2801653, AMG458, INC.280",1.88272870434424,0.43297363384094,FALSE
+"H358","Pearson.est","microtubule inhibitor",0.29972,0.827,0.633,1017,1,"vinblastine, cytochalasin.b, estramustine.phosphate, vinflunine, secnidazole, colchicine, cabazitaxel, D.64131, podophyllotoxin, triclabendazole",0.198596289982645,0,FALSE
+"H358","Pearson.est","mTOR inhibitor",0.28056,0.752,0.747,337,1,"SB.2343, torin.1, PF.04691502, AZD2014, MLN0128, XL388, WYE.125132, WYE.354, OSI.027, PKI.179",0.126679398184601,0,FALSE
+"H358","Pearson.est","NFkB pathway inhibitor",0.23699,0.636,0.888,8,1,"EVP4593",0.051587034221399,0,FALSE
+"H358","Pearson.est","opioid receptor agonist",-0.62567,-1.6,0.0499,1442,0.473,"salvinorin.a",1.30189945437661,0.325138859262188,FALSE
+"H358","Pearson.est","p38 MAPK inhibitor",-0.52606,-1.34,0.151,981,0.619,"SB.239063, VX.702, CMPD.1, TAK.715",0.821023052706831,0.208309350979882,FALSE
+"H358","Pearson.est","PARP inhibitor",-0.52088,-1.3,0.192,1012,0.548,"talazoparib, olaparib, PJ.34, niraparib",0.71669877129645,0.261219441515631,FALSE
+"H358","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.23695,-0.6,0.915,1343,1,"telatinib, tandutinib, trapidil",0.0385789059335517,0,FALSE
+"H358","Pearson.est","phosphatase inhibitor",0.33856,0.89,0.562,74,1,"GSK2830371, bis.maltolato.oxovanadium.IV.",0.250263684430939,0,FALSE
+"H358","Pearson.est","phosphodiesterase inhibitor",-0.47035,-1.17,0.297,1072,0.554,"EMD.53998, zardaverine, YM.976, cilostamide",0.527243550682788,0.25649023527157,FALSE
+"H358","Pearson.est","PI3K inhibitor",-0.24952,-0.628,0.903,1197,1,"taselisib, AZD6482, PIK.75, CH5132799, TG.100713, pilaralisib, PF.05212384",0.0443122496864942,0,FALSE
+"H358","Pearson.est","PLK inhibitor",0.49733,1.34,0.159,373,0.615,"NMS.1286937, volasertib, HMN.214, rigosertib",0.798602875679548,0.211124884224583,FALSE
+"H358","Pearson.est","potassium channel blocker",-0.43773,-1.09,0.344,1056,0.609,"meglitinide, oleoylethanolamide, dofetilide",0.46344155742847,0.215382707367125,FALSE
+"H358","Pearson.est","PPAR receptor agonist",0.49484,1.34,0.147,84,0.615,"fenofibrate, pterostilbene",0.832682665251824,0.211124884224583,FALSE
+"H358","Pearson.est","progesterone receptor agonist",0.54969,1.45,0.121,37,0.677,"tanaproget, norethindrone",0.91721462968355,0.169411331314856,FALSE
+"H358","Pearson.est","proteasome inhibitor",-0.67367,-1.7,0.0274,1092,0.432,"ONX.0914, ixazomib, ixazomib.citrate, bortezomib, carfilzomib",1.56224943717961,0.364516253185088,FALSE
+"H358","Pearson.est","protein synthesis inhibitor",0.2181,0.587,0.928,121,1,"clindamycin.phosphate, clofoctol",0.0324520237811379,0,FALSE
+"H358","Pearson.est","protein tyrosine kinase inhibitor",0.40412,1.1,0.329,88,0.776,"mubritinib, PP.121",0.482804102050026,0.110138278741812,FALSE
+"H358","Pearson.est","RAF inhibitor",-0.50533,-1.32,0.178,881,0.619,"regorafenib, CEP.32496, SB.590885, AZ.628, GDC.0879, vemurafenib, dabrafenib",0.749579997691106,0.208309350979882,FALSE
+"H358","Pearson.est","RET tyrosine kinase inhibitor",-0.49647,-1.25,0.218,881,0.552,"regorafenib, sunitinib, vandetanib, apatinib",0.661543506395395,0.258060922270801,FALSE
+"H358","Pearson.est","retinoid receptor agonist",-0.44912,-1.1,0.347,1310,0.612,"AM.580, tamibarotene, CD.437",0.459670525209126,0.213248577854439,FALSE
+"H358","Pearson.est","ribonucleotide reductase inhibitor",0.27802,0.749,0.777,178,1,"cytarabine, pentostatin, hydroxyurea",0.109578981199086,0,FALSE
+"H358","Pearson.est","serotonin receptor agonist",0.46064,1.24,0.237,73,0.674,"aripiprazole",0.625251653989896,0.17134010346468,FALSE
+"H358","Pearson.est","serotonin receptor antagonist",-0.35959,-0.912,0.553,1192,0.876,"lerisetron, SB.228357, sertindole, RS.16566",0.257274868695302,0.0574958938319193,FALSE
+"H358","Pearson.est","sodium channel blocker",0.30052,0.828,0.649,161,1,"oxcarbazepine, benzethonium, A.803467, cibenzoline",0.187755303199631,0,FALSE
+"H358","Pearson.est","src inhibitor",-0.29084,-0.737,0.801,1266,0.964,"saracatinib, PP.2",0.0963674839157623,0.0159229660971692,FALSE
+"H358","Pearson.est","sterol demethylase inhibitor",0.47098,1.29,0.177,370,0.639,"sulconazole, posaconazole, terconazole, chlormidazole",0.752026733638193,0.1944991418416,FALSE
+"H358","Pearson.est","TGF beta receptor inhibitor",-0.49094,-1.25,0.223,1227,0.552,"D.4476, repsox, LY2109761",0.651695136951839,0.258060922270801,FALSE
+"H358","Pearson.est","thymidylate synthase inhibitor",-0.61318,-1.55,0.0564,1039,0.444,"trifluridine, raltitrexed, carmofur, doxifluridine",1.24872089601666,0.35261702988538,FALSE
+"H358","Pearson.est","topoisomerase inhibitor",-0.43851,-1.11,0.335,1263,0.617,"SN.38, camptothecin, irinotecan, licochalcone.a, genz.644282, exatecan.mesylate",0.474955192963155,0.209714835966758,FALSE
+"H358","Pearson.est","tubulin polymerization inhibitor",0.21101,0.556,0.955,1000,0.986,"verubulin, vindesine, vinblastine, CYT.997, ABT.751, BNC105, mebendazole, dolastatin.10, fenbendazole, parbendazole, docetaxel, vincristine, indibulin, flubendazole, nocodazole, plinabulin, albendazole, vinorelbine, taltobulin, oxibendazole, epothilone.b, podophyllotoxin, fosbretabulin, paclitaxel, epothilone.d, KX2.391",0.0199966284162537,0.0061230850587888,FALSE
+"H358","Pearson.est","tyrosine kinase inhibitor",-0.23646,-0.592,0.931,878,1,"tyrphostin.AG.99, regorafenib, bafetinib, rheochrysidin, sunitinib, CP.724714, tyrphostin.A9, vandetanib, BMS.599626, AV.412, apatinib, tivantinib, AMG.208",0.0310503190186574,0,FALSE
+"H358","Pearson.est","VEGFR inhibitor",-0.19149,-0.479,0.988,873,0.985,"cediranib, regorafenib, XL.647, vatalanib, MK.2461, foretinib, sunitinib, BMS.690514, orantinib, AEE788, lucitanib, vandetanib, golvatinib, telatinib, MGCD.265",0.00524305541237188,0.00656376950238827,FALSE
+"H358","Pearson.est","vitamin D receptor agonist",-0.46559,-1.17,0.278,1215,0.554,"maxacalcitol, ercalcitriol, calcitriol",0.555955204081924,0.25649023527157,FALSE
+"A549","Pearson.est","EGFR inhibitor",0.69799,1.75,0.0167,139,0.584,"pelitinib, dacomitinib, tucatinib, AZD8931, osimertinib, afatinib, CP.724714, WZ8040, canertinib, OSI.420, gefitinib, AEE788, poziotinib, icotinib, neratinib, erlotinib, ARRY.334543, BMS.690514, AST.1306, BMS.599626, vandetanib",1.77728352885242,0.233587152887601,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",0.3852,0.963,0.489,177,0.782,"ZM.306416, imatinib, flumatinib",0.31069114087638,0.106793246940152,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",-0.33589,-0.877,0.586,1366,0.866,"nicotine",0.232102383981909,0.0624821079826534,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",0.61234,1.52,0.0719,565,0.585,"dicycloverine, darifenacin, hyoscyamine, diphemanil, methscopolamine, iododexetimide",1.14327110961712,0.23284413391782,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.6438,1.66,0.0373,496,0.497,"CGS.15943, MRS.1220, SCH.58261, istradefylline, sulmazole, PSB.1115",1.42829116819131,0.303643611266668,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",0.39275,1.01,0.442,406,0.826,"oxymetazoline, methyldopa, A61603, isoxsuprine, isoetharine, clenbuterol, xylazine",0.354577730650908,0.0830199526796178,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",0.40265,1.03,0.403,298,0.882,"atenolol...., RS.17053, dronedarone, pindolol, oxprenolol, prazosin",0.39469495385889,0.0545314148681803,FALSE
+"A549","Pearson.est","AKT inhibitor",0.37852,0.967,0.476,227,0.799,"CCT128930, palomid.529, uprosertib",0.322393047279507,0.0974532206860086,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.27572,-0.724,0.786,1141,0.872,"alectinib, AZD3463, lorlatinib, crizotinib",0.104577453960592,0.0594835150674328,FALSE
+"A549","Pearson.est","androgen receptor antagonist",0.55479,1.41,0.144,648,0.495,"cyproterone.acetate, nilutamide, flutamide, enzalutamide, RU.58841, bicalutamide",0.84163750790475,0.305394801066431,FALSE
+"A549","Pearson.est","antioxidant",-0.5227,-1.35,0.153,1188,0.317,"trolox, rutin, chlorogenic.acid, mesna",0.815308569182401,0.498940737782249,FALSE
+"A549","Pearson.est","AP inhibitor",0.65772,1.67,0.0471,288,0.628,"embelin, tanshinone.i, LCL.161",1.3269790928711,0.202040356262804,FALSE
+"A549","Pearson.est","ATPase inhibitor",-0.40148,-1.04,0.402,1288,0.674,"rabeprazole, digitoxigenin, oligomycin.a",0.39577394691553,0.17134010346468,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.6084,-1.56,0.0759,1217,0.417,"alisertib, CCT137690, danusertib, MLN.8054, TAK.901, hesperadin, AT.9283, PF.03814735, GSK1070916, MK.8745, MK.5108, AMG900",1.11975822410452,0.379863945026242,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.27847,0.702,0.808,1047,0.902,"dirithromycin, tilmicosin, josamycin, valnemulin, tedizolid, radezolid, azithromycin, azalomycin.b",0.0925886392254138,0.0447934624580583,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",-0.53394,-1.41,0.122,1313,0.348,"lomefloxacin, novobiocin, finafloxacin",0.913640169325252,0.458420756053419,FALSE
+"A549","Pearson.est","BCL inhibitor",0.5263,1.32,0.162,247,0.558,"ABT.737, navitoclax, obatoclax",0.790484985457369,0.253365801062421,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.3087,0.805,0.689,177,0.846,"imatinib, flumatinib",0.161780778092374,0.0726296369609765,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",0.40284,1.05,0.377,293,0.913,"temazepam, CL.218872, indiplon, piperazine, gamma.aminobutyric.acid",0.423658649794207,0.039529222465701,FALSE
+"A549","Pearson.est","bromodomain inhibitor",0.32751,0.841,0.63,502,0.806,"I.BET151, I.BET.762, JQ1...., bromosporine",0.200659450546418,0.0936649581949093,FALSE
+"A549","Pearson.est","calcium channel blocker",0.35934,0.906,0.553,370,0.774,"SKF.96365, tetrandrine, mibefradil, efonidipine.monoethanolate, fendiline",0.257274868695302,0.111259039317107,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",-0.45726,-1.17,0.273,1317,0.525,"UNBS.5162, ZK811752",0.563837352959244,0.279840696594043,FALSE
+"A549","Pearson.est","CDK inhibitor",0.34133,0.877,0.605,152,0.785,"CR8..R., BMS.387032, TG.02, indirubin, AT.7519, dinaciclib",0.218244625347531,0.105130343254747,FALSE
+"A549","Pearson.est","CHK inhibitor",0.58127,1.49,0.0763,40,0.579,"PF.477736",1.11747546204512,0.237321436272564,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",-0.20648,-0.522,0.962,1037,0.973,"phenazone, amfenac, meloxicam, aspirin, metoxibutropate, suxibuzone, tepoxalin, curcumin, acetylsalicylsalicylic.acid",0.0168249279621871,0.0118871597316481,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",0.36402,0.931,0.534,609,0.77,"morin, itraconazole, metyrapone, cobicistat, clotrimazole",0.272458742971444,0.113509274827518,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.32488,-0.824,0.655,1186,0.848,"TH.302, mitomycin.c, satraplatin, cyclophosphamide, carboplatin",0.183758700008217,0.0716041477432862,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.59924,-1.53,0.0998,1178,0.393,"tirapazamine, chlorambucil, oxaliplatin, sangivamycin, metronidazole, valrubicin, teroxirone, carboplatin",1.00086945871263,0.405607449624573,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",0.2855,0.744,0.74,421,0.881,"fdcyd, SGI.1027, RG108, azacitidine",0.130768280269024,0.0550240915879521,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",0.25392,0.654,0.876,324,0.905,"menadione, famciclovir, cidofovir",0.0574958938319193,0.0433514207947967,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.4077,-1.09,0.36,1022,0.624,"altretamine, artemisinin, anisomycin, azodicarbonamide, CB.10.277, mitomycin.c, cyclocytidine, artesunate, floxuridine",0.443697499232713,0.204815410317576,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",0.23811,0.609,0.913,175,0.93,"lurasidone, mesoridazine, nemonapride",0.039529222465701,0.0315170514460649,FALSE
+"A549","Pearson.est","estrogen receptor agonist",-0.29428,-0.763,0.701,1121,0.88,"estradiol.cypionate, estrone, levonorgestrel",0.154281982033341,0.0555173278498314,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.2933,0.753,0.76,89,0.909,"tamoxifen",0.119186407719209,0.0414361167780325,FALSE
+"A549","Pearson.est","FGFR inhibitor",0.55741,1.4,0.14,340,0.477,"orantinib, PD.173074, erdafitinib, lucitanib, lenvatinib",0.853871964321762,0.321481620959886,FALSE
+"A549","Pearson.est","FLT3 inhibitor",0.19746,0.49,0.979,500,0.983,"TG.02, pacritinib, tandutinib, TG.101348, gilteritinib, sorafenib, sunitinib",0.00921730819686218,0.00744648216786438,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.27503,-0.712,0.802,1113,0.858,"dexamethasone.acetate, beclomethasone.dipropionate, prednisolone, fluocinolone.acetonide, triamcinolone, ciclesonide, desonide, fluticasone.propionate",0.0958256317158365,0.0665127121512946,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.56527,1.45,0.108,492,0.549,"LY456236, CPP, kynurenic.acid, MTPG, diazooxonorleucine, JNJ.16259685, latrepirdine, ACDPP, felbamate, IEM1754",0.96657624451305,0.260427655549908,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",0.27913,0.707,0.802,310,0.915,"indirubin, GSK.3.inhibitor.IX",0.0958256317158365,0.0385789059335517,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",-0.57284,-1.44,0.118,1179,0.382,"AZD3463, lestaurtinib, danusertib, PHA.848125",0.928117992693875,0.417936637088291,FALSE
+"A549","Pearson.est","HCV inhibitor",0.63814,1.65,0.0423,489,0.421,"embelin, PSI.7976, narlaprevir, daclatasvir",1.37365963262496,0.375717904164332,FALSE
+"A549","Pearson.est","HDAC inhibitor",0.29041,0.746,0.768,434,0.898,"pyroxamide, nexturastat.a, SB.939, vorinostat, R306465, belinostat, panobinostat, RG2833",0.114638779968488,0.0467236633326956,FALSE
+"A549","Pearson.est","histamine receptor antagonist",0.54233,1.41,0.13,510,0.495,"chloropyramine, tecastemizole, ICI.162846, astemizole, cyproheptadine, tiotidine, epinastine, terfenadine, nizatidine, cimetidine, levocetirizine, BF2.649, famotidine",0.886056647693163,0.305394801066431,FALSE
+"A549","Pearson.est","HMGCR inhibitor",-0.58618,-1.49,0.0776,1108,0.351,"fluvastatin, pitavastatin, simvastatin",1.11013827874181,0.454692883534176,FALSE
+"A549","Pearson.est","HSP inhibitor",-0.24733,-0.646,0.884,1205,0.909,"ganetespib, PU.H71, NMS.E973, BIIB021",0.0535477349869269,0.0414361167780325,FALSE
+"A549","Pearson.est","JAK inhibitor",0.33189,0.856,0.628,249,0.799,"TG.02, LY2784544, AZD1480, atiprimod, pacritinib",0.202040356262804,0.0974532206860086,FALSE
+"A549","Pearson.est","KIT inhibitor",0.45635,1.18,0.269,500,0.733,"imatinib, cediranib, motesanib, pazopanib, tandutinib, lenvatinib, telatinib, sorafenib, vatalanib, sunitinib",0.570247719997592,0.134896025358872,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.65691,-1.68,0.039,1122,0.292,"nutlin.3, serdemetan, RITA, idasanutlin",1.4089353929735,0.534617148551582,FALSE
+"A549","Pearson.est","MEK inhibitor",-0.54657,-1.4,0.139,1173,0.331,"MEK162, PD.198306, AS.703026, trametinib, AZD8330, PD.98059, PD.184352, PD.318088, PD.0325901, Ro.4987655, refametinib",0.856985199745905,0.480172006224281,FALSE
+"A549","Pearson.est","MET inhibitor",-0.33029,-0.864,0.589,1331,0.852,"PF.04217903",0.229884705212898,0.0695604052332999,FALSE
+"A549","Pearson.est","microtubule inhibitor",-0.36484,-0.958,0.471,1127,0.75,"cabazitaxel, D.64131, secnidazole, vinflunine, vinblastine",0.326979092871104,0.1249387366083,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.58724,-1.52,0.0888,1068,0.352,"deforolimus, OSI.027, sirolimus, GDC.0980, PI.103, AZD2014, WYE.125132, voxtalisib, XL388, PF.04691502, NVP.BEZ235, LY303511, GSK2126458, PKI.179, MLN0128, torin.1, ku.0063794, PP242, SB.2343",1.0515870342214,0.453457336521869,FALSE
+"A549","Pearson.est","NFkB pathway inhibitor",0.42986,1.1,0.337,145,0.836,"Ro.106.9920, parthenolide, tyloxapol, bortezomib",0.472370099128661,0.0777937225609836,FALSE
+"A549","Pearson.est","opioid receptor agonist",0.36717,0.945,0.478,178,0.767,"ADL5859, salvinorin.a",0.320572103387881,0.115204636051019,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",0.25811,0.668,0.86,404,0.907,"TAK.715, SB.242235, SB.239063",0.0655015487564323,0.0423927129399047,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.33705,-0.859,0.617,1006,0.824,"AG.14361, AZD2461, niraparib, talazoparib, olaparib",0.209714835966758,0.0840727883028842,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.39537,1.02,0.4,532,0.837,"orantinib, imatinib, motesanib, pazopanib, tandutinib, linifanib, lenvatinib, telatinib, sorafenib, vatalanib, trapidil, sunitinib, CP.673451",0.397940008672038,0.07727454200674,FALSE
+"A549","Pearson.est","phosphatase inhibitor",-0.28521,-0.735,0.755,1367,0.888,"mycophenolic.acid, bis.maltolato.oxovanadium.IV.",0.122053048370812,0.051587034221399,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",0.40097,1.03,0.415,205,0.882,"cilostamide, avanafil, anagrelide",0.381951903287907,0.0545314148681803,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.5217,-1.38,0.122,1170,0.33,"CH5132799, GDC.0980, PI.103, voxtalisib, PF.04691502, NVP.BEZ235, LY303511, buparlisib, ZSTK.474, GSK2126458, PKI.179, GDC.0941, YM.201636, SB.2343",0.913640169325252,0.481486060122112,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.78071,-2.02,0.0042,1125,0.0791,"BI.2536, volasertib, rigosertib, NMS.1286937, GSK461364, GW.843682X, HMN.214",2.3767507096021,1.10182351650232,TRUE
+"A549","Pearson.est","potassium channel blocker",0.3741,0.961,0.467,292,0.762,"dofetilide, oleoylethanolamide",0.330683119433888,0.1180450286604,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.50919,1.34,0.152,292,0.554,"S26948, GW.501516, oleoylethanolamide",0.818156412055227,0.25649023527157,FALSE
+"A549","Pearson.est","progesterone receptor agonist",-0.29156,-0.776,0.74,1104,0.894,"nomegestrol.acetate, levonorgestrel, norethindrone, tanaproget",0.130768280269024,0.0486624812040823,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.40861,1.02,0.419,437,0.837,"carfilzomib, bortezomib, ixazomib.citrate, oprozomib",0.377785977033705,0.07727454200674,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.37086,-0.972,0.443,1053,0.763,"anguidine, thiostrepton, methacycline, harringtonine, chloramphenicol.palmitate, mercaptopurine, cycloheximide",0.35359627377693,0.11747546204512,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",0.55725,1.45,0.108,261,0.549,"CP.724714, BMS.599626, AV.412",0.96657624451305,0.260427655549908,FALSE
+"A549","Pearson.est","RAF inhibitor",0.49044,1.26,0.203,221,0.637,"dabrafenib, GDC.0879, CEP.32496, PLX.4720",0.692503962086787,0.19586056766465,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",0.34361,0.884,0.575,500,0.793,"vandetanib, apatinib, sorafenib, sunitinib",0.24033215531037,0.100726812682396,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.39706,1,0.421,266,0.817,"adarotene, tamibarotene, fenretinide",0.375717904164332,0.0877779434675845,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",-0.54322,-1.42,0.126,1028,0.369,"triapine, gemcitabine, fludarabine.phosphate, clofarabine, fludarabine, cladribine, hydroxyurea",0.899629454882437,0.43297363384094,FALSE
+"A549","Pearson.est","serotonin receptor agonist",0.63096,1.6,0.0585,1,0.468,"aripiprazole",1.23284413391782,0.329754146925876,FALSE
+"A549","Pearson.est","serotonin receptor antagonist",0.56603,1.44,0.113,100,0.52,"aripiprazole, lurasidone, lerisetron",0.94692155651658,0.283996656365201,FALSE
+"A549","Pearson.est","sodium channel blocker",0.27157,0.687,0.843,103,0.903,"triamterene, lappaconite",0.0741724253752577,0.0443122496864942,FALSE
+"A549","Pearson.est","src inhibitor",0.4546,1.16,0.294,184,0.739,"ZM.306416, PP.1, saracatinib",0.531652669587843,0.131355561605174,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",-0.71174,-1.78,0.0235,1380,0.327,"chlormidazole, lanoconazole",1.62893213772826,0.485452247339714,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",0.77692,1.97,0.00194,234,0.2,"SB.431542, LY2109761, D.4476, repsox, SB.525334",2.71219827006977,0.698970004336019,TRUE
+"A549","Pearson.est","thymidylate synthase inhibitor",0.38422,0.974,0.48,149,0.812,"doxifluridine, capecitabine",0.318758762624413,0.0904439707588247,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.63925,-1.69,0.0323,1098,0.363,"topotecan, camptothecin, teniposide, genz.644282, nemorubicin, SN.38, rubitecan, etoposide, amonafide, valrubicin, idarubicin, doxorubicin, voreloxin, epirubicin, TAS.103, mitoxantrone, amsacrine",1.4907974776689,0.440093374963888,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",-0.5197,-1.37,0.127,1189,0.317,"KX2.391, fenbendazole, oxibendazole, epothilone.b, taltobulin, vinblastine, mebendazole, verubulin, BNC105",0.896196279044043,0.498940737782249,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",0.3591,0.915,0.526,323,0.779,"CP.724714, hypericin, BMS.599626, vandetanib, tivantinib, AV.412, apatinib",0.279014255846261,0.108462542327436,FALSE
+"A549","Pearson.est","VEGFR inhibitor",0.46172,1.19,0.24,500,0.751,"orantinib, golvatinib, ZM.306416, PD.173074, AEE788, cediranib, motesanib, BMS.690514, vandetanib, pazopanib, lucitanib, linifanib, XL.647, lenvatinib, TG.100572, semaxanib, telatinib, sorafenib, vatalanib, MK.2461, tivozanib, sunitinib",0.619788758288394,0.124360062995832,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",0.3768,0.976,0.448,297,0.836,"paricalcitol, alfacalcidol, tacalcitol",0.348721986001856,0.0777937225609836,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",-0.38652,-1.06,0.373,1132,1,"salvianolic.acid.B, WZ.4002, pelitinib, XL.647, GW.583340, tyrphostin.AG.1478, BIBU.1361, PD.153035, gefitinib, BIBX.1382, icotinib, OSI.420, CNX.2006, erlotinib, rociletinib, vandetanib, WZ8040, PD.168393, CGP.52411",0.428291168191312,0,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",-0.23329,-0.623,0.879,335,0.993,"flumatinib, bafetinib, nilotinib, imatinib, tozasertib, metatinib, KW.2449, GZD824, ZM.306416, bosutinib, ponatinib, dasatinib",0.0560111249262281,0.00305075150461883,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",0.6281,1.57,0.062,149,0.822,"xanomeline, oxiracetam, tremorine",1.20760831050175,0.0851281824599496,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",0.47883,1.21,0.257,753,0.649,"hyoscyamine, dicycloverine, darifenacin, iododexetimide, diphemanil",0.590066876668705,0.187755303199631,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",0.25799,0.633,0.896,456,0.911,"MRS.1220, PSB.1115, sulmazole",0.0476919903378748,0.0404816230270017,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",0.26164,0.648,0.87,359,0.915,"ritodrine, lidamidine, clenbuterol, isoxsuprine",0.0604807473813815,0.0385789059335517,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",0.21637,0.541,0.958,308,0.961,"atipamezole, atenolol......, idazoxan, propranolol, naftidrofuryl",0.0186344909214556,0.0172766123314547,FALSE
+"HCC15","Pearson.est","AKT inhibitor",-0.30982,-0.857,0.614,1166,1,"GSK2110183, CCT128930, AT7867",0.211831628858832,0,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.35289,-0.986,0.44,1228,1,"GW.788388, alectinib, AP26113, lorlatinib",0.356547323513813,0,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",0.55579,1.38,0.143,568,0.714,"cyproterone.acetate, nilutamide, flutamide, bicalutamide, enzalutamide",0.844663962534938,0.146301788223826,FALSE
+"HCC15","Pearson.est","antioxidant",-0.50475,-1.35,0.171,1239,0.824,"benfotiamine, rutin, mesna",0.767003889607846,0.0840727883028842,FALSE
+"HCC15","Pearson.est","AP inhibitor",-0.38474,-1.04,0.399,1428,1,"embelin",0.399027104313252,0,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",0.51328,1.29,0.176,281,0.771,"k.strophanthidin, evodiamine, digoxin, NMS.873, digitoxin",0.75448733218585,0.112945621949043,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",-0.30022,-0.832,0.657,1024,0.962,"alisertib, MK.8745, PF.03814735, TAK.901, AT.9283, barasertib.HQPA, CCT129202, GSK1070916, hesperadin, MLN.8054, CYC116",0.182434630440219,0.0168249279621871,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.35021,0.872,0.624,558,0.874,"josamycin, azithromycin, dirithromycin, tedizolid, tilmicosin",0.204815410317576,0.058488567365597,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.43702,1.08,0.358,330,0.679,"norfloxacin, sarafloxacin, trovafloxacin, sparfloxacin",0.446116973356126,0.168130225719498,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.50347,1.26,0.213,620,0.74,"TW.37, oridonin, HA14.1, venetoclax, gossypol, ABT.737",0.671620396561262,0.130768280269024,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.23296,-0.635,0.901,335,1,"flumatinib, bafetinib, nilotinib, imatinib, tozasertib, metatinib, GZD824, bosutinib, ponatinib, dasatinib",0.045275209020937,0,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",0.46792,1.15,0.293,252,0.713,"ZK.93423, temazepam, indiplon, bentazepam",0.533132379645891,0.146910470148134,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.59131,1.46,0.0768,543,0.551,"PFI.1, JQ1...., bromosporine, I.BET151",1.11463877996849,0.258848401148215,FALSE
+"HCC15","Pearson.est","calcium channel blocker",0.478,1.18,0.26,449,0.679,"fendiline, carboxyamidotriazole, tetrandrine, pranidipine, efonidipine.monoethanolate, SKF.96365",0.585026652029182,0.168130225719498,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",0.29485,0.733,0.797,596,0.894,"UNBS.5162, SB.225002, ZK811752, MK.0812, PF.04136309",0.0985416786038876,0.0486624812040823,FALSE
+"HCC15","Pearson.est","CDK inhibitor",-0.17742,-0.483,0.992,253,0.985,"BMS.387032, CR8..R., PHA.848125, PHA.793887, indisulam, kenpaullone, arcyriaflavin.a, JNJ.7706621, TG.02, AZD5438, dinaciclib, P276.00, AT.7519, abemaciclib, alvocidib, BMS.265246, R547, indirubin, aminopurvalanol.a, NU6027, palbociclib, ribociclib",0.00348832784582135,0.00656376950238827,FALSE
+"HCC15","Pearson.est","CHK inhibitor",0.49536,1.23,0.232,505,0.676,"PF.477736, LY2606368, CHIR.124, SB.218078, LY2603618",0.6345120151091,0.170053304058364,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.35461,-0.962,0.485,1120,1,"curcumin, meloxicam, acetylsalicylsalicylic.acid, indoprofen, tryptanthrin, amfenac, pterostilbene",0.314258261397736,0,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",0.43791,1.09,0.372,735,0.712,"eplerenone, morin, itraconazole, PF.4981517, metyrapone",0.429457060118102,0.147520006363144,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",-0.29167,-0.792,0.681,1234,0.918,"carboplatin, streptozotocin, cyclophosphamide, TH.302, dianhydrogalactitol",0.166852888087215,0.0371573187987575,FALSE
+"HCC15","Pearson.est","DNA inhibitor",0.33575,0.826,0.671,417,0.882,"mechlorethamine, teroxirone, valrubicin, metronidazole, melphalan, primaquine, sangivamycin, bendamustine",0.173277479831008,0.0545314148681803,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.5169,1.28,0.201,406,0.739,"SGI.1027, decitabine, disulfiram",0.696803942579511,0.131355561605174,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.42252,1.06,0.389,353,0.646,"trifluridine, idoxuridine, menadione",0.410050398674292,0.189767482004916,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",0.32144,0.804,0.683,378,0.852,"azodicarbonamide, artesunate, floxuridine, mitomycin.c",0.165579296318467,0.0695604052332999,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",-0.44029,-1.18,0.256,1200,0.844,"nemonapride, amisulpride, clebopride, remoxipride, acetophenazine, oxiperomide",0.59176003468815,0.073657553374345,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.31142,-0.864,0.612,1419,1,"PPT",0.213248577854439,0,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",-0.31137,-0.879,0.584,449,1,"danazol, clomifene, toremifene, tamoxifen, raloxifene, fulvestrant",0.233587152887601,0,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.59685,1.49,0.0876,229,0.947,"regorafenib, dovitinib, erdafitinib, nintedanib",1.05749589383192,0.0236500209967266,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.3372,0.822,0.663,377,0.844,"dovitinib, sorafenib, GTP.14564, quizartinib, tandutinib",0.178486471595227,0.073657553374345,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.18591,-0.504,0.986,1329,1,"fluticasone.propionate, fluorometholone, prednisolone.acetate",0.0061230850587888,0,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",-0.27701,-0.745,0.746,1309,0.965,"CPP, latrepirdine, SIB.1757",0.127261172527331,0.0154726866562074,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",-0.29882,-0.825,0.617,430,0.932,"AZD2858, tideglusib, kenpaullone, CHIR.99021, GSK.3.inhibitor.IX, TWS.119, indirubin, CHIR.98014, LY2090314",0.209714835966758,0.0305840876460186,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",0.33223,0.825,0.679,321,0.861,"GSK1838705A, PHA.848125",0.168130225719498,0.0649968485463452,FALSE
+"HCC15","Pearson.est","HCV inhibitor",-0.46572,-1.25,0.194,1379,0.862,"Ro.9187, embelin",0.712198270069774,0.0644927341752872,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",-0.31444,-0.867,0.593,1250,1,"romidepsin, entinostat, tacedinaline, RG2833, mocetinostat, JNJ.26481585",0.226945306635737,0,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",-0.30731,-0.843,0.632,1354,0.983,"levocetirizine, tiotidine, pheniramine",0.199282921717615,0.00744648216786438,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",-0.46536,-1.25,0.202,1401,0.862,"simvastatin",0.694648630553376,0.0644927341752872,FALSE
+"HCC15","Pearson.est","HSP inhibitor",0.53557,1.32,0.148,539,0.82,"SNX.2112, KW.2478, NMS.E973, SNX.5422, ganetespib, BIIB021, NVP.AUY922, guanidine, PU.H71, XL888",0.829738284605043,0.0861861476162833,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.2889,0.712,0.796,211,0.9,"baricitinib, CEP.33779, AZD1480",0.0990869322623309,0.0457574905606751,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.39173,0.971,0.486,236,0.762,"regorafenib, OSI.930, sorafenib, pazopanib, masitinib",0.313363730737707,0.1180450286604,FALSE
+"HCC15","Pearson.est","MDM inhibitor",-0.86092,-2.33,0,1352,0.00694,"CGM097, idasanutlin, AMG.232, RITA",Inf,2.15864052954515,TRUE
+"HCC15","Pearson.est","MEK inhibitor",-0.81982,-2.22,0,1257,0.0202,"BIX.02188, PD.98059, U.0126, PD.198306, PD.0325901, MEK162, PD.184352, PD.318088, trametinib, cobimetinib, TAK.733, AS.703026, AZD8330, refametinib, selumetinib, Ro.4987655",Inf,1.69464863055338,TRUE
+"HCC15","Pearson.est","MET inhibitor",-0.54167,-1.44,0.12,1208,0.904,"INC.280, PHA.665752, PF.04217903",0.920818753952375,0.0438315695246367,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.60121,1.47,0.0683,442,0.6,"colchicine, vinblastine, D.64131, vinflunine, cabazitaxel, podophyllotoxin, triclabendazole",1.16557929631847,0.221848749616356,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",-0.44858,-1.24,0.196,1020,0.788,"GSK2126458, torin.1, MLN0128, OSI.027, temsirolimus, AZD8055, PF.04691502, LY3023414, SB.2343, GDC.0980, NVP.BEZ235, WYE.354, XL388, sirolimus, PF.05212384",0.707743928643524,0.103473782510445,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",-0.30491,-0.873,0.595,1263,1,"Ro.106.9920, parthenolide, BAY.11.7082, parthenolide....",0.22548303427145,0,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",0.37916,0.952,0.505,282,0.774,"cebranopadol, spiradoline, trimebutine",0.296708621881339,0.111259039317107,FALSE
+"HCC15","Pearson.est","p38 MAPK inhibitor",-0.26024,-0.689,0.842,375,0.98,"talmapimod, SB.242235, SB.239063, TAK.715, VX.702, CMPD.1, skepinone.l",0.0746879085003505,0.00877392430750515,FALSE
+"HCC15","Pearson.est","PARP inhibitor",-0.35055,-0.956,0.483,1246,1,"E7449, endo.IWR.1",0.316052869248488,0,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3086,0.761,0.745,307,0.875,"regorafenib, dovitinib, sorafenib, pazopanib, nintedanib, masitinib, crenolanib",0.127843727251707,0.0579919469776868,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.6019,1.48,0.0824,435,0.799,"AS.1949490, CID.5458317, GSK2830371, sodium.stibogluconate, menadione, mycophenolic.acid",1.08407278830288,0.0974532206860086,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",0.43394,1.07,0.365,497,0.65,"enoximone, avanafil, EMD.53998, cilostamide",0.437707135543525,0.187086643357144,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",-0.2778,-0.741,0.763,1000,0.935,"CUDC.907, GSK2126458, PI3K.IN.2, ZSTK.474, alpelisib, PIK.75, pilaralisib, PF.04691502, CH5132799, GDC.0941, LY3023414, SB.2343, GDC.0980, NVP.BEZ235, PF.05212384",0.11747546204512,0.0291883891274822,FALSE
+"HCC15","Pearson.est","PLK inhibitor",0.76613,1.89,0,344,0.215,"volasertib, NMS.1286937, GW.843682X, BI.2536, HMN.214, rigosertib, GSK461364",Inf,0.667561540084395,TRUE
+"HCC15","Pearson.est","potassium channel blocker",0.45215,1.12,0.338,158,0.712,"ML133, dofetilide",0.471083299722345,0.147520006363144,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.50402,-1.38,0.135,1138,0.894,"GW.501516, clofibrate, fenofibrate, pterostilbene",0.869666231504994,0.0486624812040823,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.28978,-0.794,0.688,417,0.952,"norethindrone, danazol, norethindrone.acetate, melengestrol.acetate, nomegestrol.acetate, tanaproget, norgestrel, dienogest, levonorgestrel",0.162411561764489,0.0213630516155257,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.36987,0.923,0.534,58,0.803,"MG.132",0.272458742971444,0.095284454721319,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",0.50191,1.25,0.212,617,0.715,"puromycin, clofoctol, thiostrepton, homoharringtonine, harringtonine, bruceantin, methacycline, anguidine, cycloheximide, chloramphenicol.palmitate, mercaptopurine, emetine, tedizolid.phosphate",0.673664139071249,0.145693958198919,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",0.49997,1.22,0.242,218,0.662,"tyrphostin.A9, PP.121, mubritinib",0.616184634019569,0.1791420105603,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.52448,1.3,0.192,540,0.807,"SB.590885, regorafenib, RAF265, sorafenib, TAK.632, PLX.4720, GDC.0879, dabrafenib, vemurafenib",0.71669877129645,0.0931264652779296,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.43876,1.08,0.377,142,0.679,"regorafenib, sorafenib",0.423658649794207,0.168130225719498,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",0.40454,1.02,0.439,9,0.695,"adarotene",0.357535479757879,0.158015195409886,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",0.33036,0.828,0.674,612,0.902,"fludarabine.phosphate, triapine, hydroxyurea, LY2334737, gemcitabine, cladribine, cytarabine",0.17134010346468,0.0447934624580583,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",0.44725,1.11,0.344,124,0.702,"pardoprunox, zolmitriptan",0.46344155742847,0.153662887870195,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",0.45891,1.14,0.301,346,0.702,"SB.200646, lerisetron, sertindole, pirenperone, tropisetron, lurasidone",0.521433504406157,0.153662887870195,FALSE
+"HCC15","Pearson.est","sodium channel blocker",-0.1827,-0.493,0.968,1194,1,"mexiletine, lappaconite, benzocaine, butamben",0.0141246426916063,0,FALSE
+"HCC15","Pearson.est","src inhibitor",0.2849,0.708,0.803,279,0.886,"KX2.391, masitinib, TG.100572",0.095284454721319,0.0525662781129492,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",0.31262,0.764,0.766,48,0.891,"chlormidazole",0.115771230367396,0.0501222959631252,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.28295,0.694,0.825,167,0.884,"LY2109761",0.0835460514500749,0.0535477349869269,FALSE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",0.5842,1.47,0.0927,227,0.6,"trifluridine, raltitrexed, ftorafur",1.0329202658555,0.221848749616356,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",0.49744,1.23,0.217,216,0.676,"dexrazoxane, exatecan.mesylate, epirubicin, daunorubicin, topotecan, etoposide.phosphate, mitoxantrone, doxorubicin, valrubicin, SN.38",0.66354026615147,0.170053304058364,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.65572,1.6,0.0424,437,1,"vinorelbine, vindesine, vincristine, taltobulin, vinblastine, parbendazole, BNC105, dolastatin.10, paclitaxel, verubulin, fenbendazole, CYT.997, docetaxel, oxibendazole, KX2.391, flubendazole, albendazole, nocodazole, ABT.751, podophyllotoxin, fosbretabulin, indibulin, epothilone.b",1.37263414340727,0,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.43986,1.07,0.374,218,0.65,"tivantinib, tyrphostin.A9, regorafenib, hypericin, sorafenib, PP.121, GTP.14564, mubritinib",0.42712839779952,0.187086643357144,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.35742,0.869,0.629,279,0.855,"regorafenib, RAF265, dovitinib, OSI.930, sorafenib, pazopanib, tivozanib, nintedanib, TG.100572",0.201349354554731,0.0680338852718274,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",-0.69106,-1.88,0.0108,1134,0.193,"calcitriol, tacalcitol, maxacalcitol, paricalcitol, ercalcitriol, doxercalciferol",1.96657624451305,0.714442690992226,TRUE
+"HCC44","Pearson.est","EGFR inhibitor",0.58846,1.67,0.0425,394,0.371,"AEE788, AZD8931, tucatinib, GW.583340, CP.724714, dacomitinib, CNX.2006, canertinib, BIBX.1382, poziotinib, BMS.690514, neratinib, gefitinib, ARRY.334543, afatinib, WZ8040, pelitinib, OSI.420, osimertinib, PD.153035, salvianolic.acid.B, vandetanib, XL.647, CUDC.101, icotinib, WZ.4002, PD.168393",1.37161106994969,0.430626090384954,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",-0.57634,-1.46,0.0935,1061,0.367,"dasatinib, ponatinib, bafetinib, tozasertib, GZD824, KW.2449",1.02918838912748,0.435333935747911,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",-0.4165,-1.03,0.402,1215,0.788,"tremorine, nicotine",0.39577394691553,0.103473782510445,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",0.85629,2.34,0,158,0.00236,"dicycloverine, diphemanil, darifenacin, iododexetimide",Inf,2.62708799702989,TRUE
+"HCC44","Pearson.est","adenosine receptor antagonist",0.57518,1.61,0.0676,103,0.37,"CGS.15943, istradefylline, MRS.1220",1.17005330405836,0.431798275933005,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",-0.32066,-0.79,0.733,997,1,"clenbuterol, terbutaline, midodrine, metaraminol, norepinephrine, buphenine, epinephrine",0.134896025358872,0,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",0.40547,1.11,0.307,100,0.749,"RS.17053, prazosin, atenolol......, atenolol....",0.512861624522813,0.125518182300534,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.28401,-0.706,0.818,919,0.908,"uprosertib, ONC201, triciribine, GDC.0068",0.087246696328677,0.0419141514789149,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.25075,-0.615,0.899,1291,0.964,"alectinib, crizotinib",0.0462403082667712,0.0159229660971692,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",-0.35987,-0.893,0.596,1145,0.93,"bicalutamide",0.224753740259764,0.0315170514460649,FALSE
+"HCC44","Pearson.est","antioxidant",-0.73284,-1.83,0.0087,1284,0.115,"chlorogenic.acid, mesna",2.06048074738138,0.939302159646388,TRUE
+"HCC44","Pearson.est","AP inhibitor",0.37141,1.05,0.362,200,0.767,"tanshinone.i, embelin",0.441291429466834,0.115204636051019,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",0.36086,1.03,0.397,81,0.714,"k.strophanthidin, blebbistatin....",0.401209493236885,0.146301788223826,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.72864,-1.81,0.00709,1243,0.103,"danusertib, AT.9283, barasertib, GSK1070916, MLN.8054, MK.8745, CCT137690, SNS.314, alisertib, tozasertib, AMG900, MK.5108, KW.2449, hesperadin, PF.03814735",2.14935376481693,0.987162775294828,TRUE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.28045,-0.71,0.811,1047,0.924,"josamycin, tedizolid",0.090979145788844,0.0343280287798933,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.70873,-1.78,0.00902,1364,0.107,"lomefloxacin, finafloxacin, novobiocin",2.04479346245806,0.97061622231479,TRUE
+"HCC44","Pearson.est","BCL inhibitor",0.19514,0.546,0.961,1167,1,"ABT.737, obatoclax, gossypol, navitoclax, HA14.1, venetoclax, oridonin, TW.37",0.0172766123314547,0,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",-0.64527,-1.6,0.032,1061,0.252,"dasatinib, ponatinib, bafetinib, tozasertib, GZD824",1.49485002168009,0.598599459218456,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",0.4494,1.26,0.202,66,0.693,"indiplon, temazepam, nefiracetam",0.694648630553376,0.159266765388193,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",-0.529,-1.32,0.168,991,0.463,"JQ1...., PFI.1, OTX015, I.BET.762",0.774690718274137,0.334419008982047,FALSE
+"HCC44","Pearson.est","calcium channel blocker",0.5276,1.38,0.137,98,0.532,"tetrandrine, fendiline, efonidipine.monoethanolate",0.863279432843593,0.274088367704952,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",-0.55633,-1.39,0.12,988,0.387,"SB.225002, RS.504393, ZK811752, navarixin, UNBS.5162",0.920818753952375,0.412289034981089,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.37449,-0.928,0.54,1027,0.946,"aminopurvalanol.a, P276.00, kenpaullone, palbociclib, PHA.848125, alvocidib, BMS.265246, PHA.793887, abemaciclib, AZD5438, R547",0.267606240177031,0.0241088635982073,FALSE
+"HCC44","Pearson.est","CHK inhibitor",0.32299,0.876,0.564,57,0.85,"PF.477736",0.248720896016658,0.0705810742857073,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",-0.29931,-0.742,0.793,1046,0.966,"ketoprofen, indoprofen, piroxicam, meloxicam, acetylsalicylsalicylic.acid, sulfasalazine, curcumin, ramifenazone, aspirin, suxibuzone",0.100726812682396,0.0150228735845067,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",-0.34646,-0.872,0.632,1124,0.944,"eplerenone, PF.4981517, cobicistat, clotrimazole",0.199282921717615,0.025028005701931,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",-0.45734,-1.13,0.323,981,0.751,"estramustine, dianhydrogalactitol, melphalan, mitomycin.c, carmustine, cyclophosphamide, TH.302, carboplatin",0.490797477668897,0.124360062995832,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.54845,-1.36,0.138,883,0.415,"mechlorethamine, metronidazole, nimorazole, sangivamycin, melphalan, carmustine, tirapazamine, teroxirone, chlorambucil, valrubicin, carboplatin",0.860120913598763,0.381951903287907,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.49629,-1.23,0.225,1221,0.566,"fdcyd, decitabine",0.647817481888638,0.247183568811729,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.2916,-0.718,0.793,1290,0.955,"foscarnet, trifluridine",0.100726812682396,0.0199966284162537,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",-0.43722,-1.07,0.388,1300,0.787,"CB.10.277, cyclocytidine, floxuridine",0.411168274405793,0.104025267640935,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",0.21323,0.593,0.913,217,1,"remoxipride, lurasidone, mesoridazine, nemonapride",0.039529222465701,0,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",-0.44416,-1.08,0.373,910,0.796,"ethinyl.estradiol, PPT, estrone, estradiol, estradiol.cypionate",0.428291168191312,0.0990869322623309,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",0.54194,1.54,0.0772,41,0.397,"tamoxifen",1.11238269966426,0.401209493236885,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",0.55788,1.53,0.0938,83,0.353,"orantinib, PD.173074, lenvatinib",1.02779716162094,0.452225294612177,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.32239,-0.793,0.714,1081,1,"ponatinib, ENMD.2076, tandutinib, gilteritinib, tozasertib, KW.2449",0.146301788223826,0,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",0.39018,1.07,0.359,293,0.778,"triamcinolone.acetonide, hydrocortisone, deflazacort, dexamethasone.acetate, piretanide, prednisolone.hemisuccinate, halcinonide, flumethasone.pivalate, betamethasone, rimexolone",0.444905551421681,0.109020403010311,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",0.44047,1.22,0.221,314,0.709,"CGP.37849, MTPG, LY456236, CPP, kynurenic.acid, latrepirdine",0.655607726314889,0.149353764816933,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.40932,-1.03,0.437,995,0.788,"CHIR.99021, kenpaullone, LY2090314, tideglusib",0.359518563029578,0.103473782510445,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.5787,-1.44,0.0979,1243,0.348,"danusertib, PHA.848125, GSK1838705A",1.00921730819686,0.458420756053419,FALSE
+"HCC44","Pearson.est","HCV inhibitor",0.41015,1.14,0.274,200,0.747,"PSI.7976, embelin",0.562249437179612,0.126679398184601,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",-0.21875,-0.541,0.952,1138,0.957,"R306465, dacinostat, entinostat, NSC.3852, trichostatin.a, givinostat",0.0213630516155257,0.0190880622231565,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",0.29145,0.835,0.624,260,0.891,"tecastemizole, ebastine, epinastine, famotidine, chloropyramine, astemizole",0.204815410317576,0.0501222959631252,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",-0.27223,-0.668,0.878,786,0.932,"mevastatin, pitavastatin, fluvastatin, simvastatin",0.0565054840938974,0.0305840876460186,FALSE
+"HCC44","Pearson.est","HSP inhibitor",-0.44079,-1.09,0.374,1111,0.808,"PU.H71, SNX.5422, SNX.2112, ganetespib, NVP.AUY922, BIIB021",0.42712839779952,0.0925886392254138,FALSE
+"HCC44","Pearson.est","JAK inhibitor",0.27556,0.765,0.727,164,0.987,"PRT062070, TG.101348, LY2784544, TG.101209, TG.02",0.138465589140962,0.00568284733036327,FALSE
+"HCC44","Pearson.est","KIT inhibitor",0.17863,0.499,0.977,83,1,"cediranib, lenvatinib",0.0101054362812269,0,FALSE
+"HCC44","Pearson.est","MDM inhibitor",-0.60825,-1.51,0.0723,1000,0.342,"serdemetan, nutlin.3, CGM097, idasanutlin",1.14086170270547,0.465973893943865,FALSE
+"HCC44","Pearson.est","MEK inhibitor",-0.66832,-1.63,0.0473,1207,0.239,"PD.318088, PD.184352, PD.198306, MEK162, AS.703026, AZD8330, PD.98059, TAK.733, cobimetinib, PD.0325901, trametinib, Ro.4987655, refametinib",1.32513885926219,0.621602099051862,TRUE
+"HCC44","Pearson.est","MET inhibitor",-0.677,-1.65,0.0198,1094,0.244,"AMG458, PHA.665752, LY2801653, PF.04217903",1.70333480973847,0.612610173661271,TRUE
+"HCC44","Pearson.est","microtubule inhibitor",-0.32959,-0.827,0.661,895,1,"cytochalasin.b, podophyllotoxin, secnidazole, cabazitaxel, D.64131, vinflunine, vinblastine",0.17979854051436,0,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",-0.30552,-0.75,0.758,1037,0.978,"AZD2014, PI.103, LY3023414, GSK2126458, MLN0128, PP242, LY303511, ku.0063794, NVP.BEZ235",0.120330794367946,0.00966114521239857,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",0.34575,0.947,0.498,2,0.834,"tyloxapol",0.302770657240282,0.0788339493622613,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.63262,-1.56,0.0353,1078,0.286,"trimebutine, spiradoline, BW.180C",1.45222529461218,0.543633966870957,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",-0.39882,-0.991,0.471,1195,0.839,"VX.702, CMPD.1",0.326979092871104,0.0762380391712997,FALSE
+"HCC44","Pearson.est","PARP inhibitor",-0.59723,-1.45,0.099,1353,0.357,"niraparib, talazoparib, olaparib",1.00436480540245,0.447331783887807,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.18705,0.523,0.975,83,1,"orantinib, lenvatinib",0.0109953843014632,0,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",0.32994,0.919,0.483,292,0.848,"menadione, mycophenolate.mofetil, BVT.948, GSK2830371",0.316052869248488,0.0716041477432862,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",0.19974,0.56,0.96,150,1,"avanafil, enoximone",0.0177287669604316,0,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",-0.29175,-0.716,0.82,957,0.936,"alpelisib, GDC.0980, buparlisib, PI.103, LY3023414, PIK.75, GDC.0941, TG.100713, GSK2126458, LY303511, NVP.BEZ235",0.0861861476162833,0.0287241512618947,FALSE
+"HCC44","Pearson.est","PLK inhibitor",-0.75955,-1.92,0.00298,1144,0.142,"rigosertib, HMN.214, GSK461364, BI.2536, volasertib, GW.843682X",2.52578373592374,0.847711655616944,TRUE
+"HCC44","Pearson.est","potassium channel blocker",-0.29228,-0.718,0.792,1316,0.955,"meglitinide",0.101274818410506,0.0199966284162537,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",0.71422,2,0.00329,88,0.0954,"S26948, GW.501516, pterostilbene",2.48280410205003,1.0204516252959,TRUE
+"HCC44","Pearson.est","progesterone receptor agonist",0.25732,0.73,0.753,301,0.967,"norethindrone.acetate, norgestrel, norethindrone, levonorgestrel",0.123205023799299,0.0145735259169983,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",0.16875,0.47,1,1205,0.99,"oprozomib, ONX.0914, carfilzomib, ixazomib.citrate, delanzomib, MG.132, bortezomib, ixazomib",0,0.00436480540245009,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",-0.31457,-0.787,0.712,1036,0.995,"brefeldin.a, emetine, thiostrepton, mercaptopurine, cycloheximide",0.147520006363144,0.00217691925427455,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.3125,0.907,0.572,272,0.828,"CP.724714, PP.121, AV.412",0.242603971206976,0.0819696632151199,FALSE
+"HCC44","Pearson.est","RAF inhibitor",-0.3116,-0.769,0.739,768,0.997,"AZ.628, PLX.4720, SB.590885, vemurafenib, dabrafenib, RAF265, LGX818",0.131355561605174,0.00130484168834428,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",-0.43198,-1.06,0.404,1345,0.779,"cabozantinib",0.393618634889395,0.108462542327436,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",-0.37587,-0.924,0.55,1150,0.925,"tamibarotene, AM.580, adapalene",0.259637310505756,0.0338582672609674,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",-0.56925,-1.41,0.109,1074,0.376,"gemcitabine, cladribine, hydroxyurea, triapine, fludarabine, fludarabine.phosphate, clofarabine",0.962573502059376,0.424812155072339,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.23662,-0.591,0.93,1252,0.964,"SR.57227A",0.0315170514460649,0.0159229660971692,FALSE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.36794,-0.922,0.55,1133,0.899,"pirenperone, RS.16566, SB.216641, SB.200646",0.259637310505756,0.0462403082667712,FALSE
+"HCC44","Pearson.est","sodium channel blocker",-0.22155,-0.545,0.963,958,0.974,"mexiletine, benzocaine, ajmaline, butamben",0.0163737128754655,0.0114410431213845,FALSE
+"HCC44","Pearson.est","src inhibitor",0.36717,1.03,0.386,175,0.714,"saracatinib, ZM.306416, PP.1",0.413412695328245,0.146301788223826,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",-0.59972,-1.5,0.0697,1367,0.327,"lanoconazole, chlormidazole",1.15676722190199,0.485452247339714,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",0.93962,2.61,0,90,0,"SB.525334, SB.431542, repsox, adaprev, LY2109761",Inf,Inf,TRUE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.51819,-1.28,0.184,1065,0.517,"ftorafur, carmofur, raltitrexed, trifluridine",0.735182176990464,0.286509456906058,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",-0.76735,-1.89,0.00295,1292,0.0966,"irinotecan, teniposide, camptothecin, nemorubicin, valrubicin, amonafide, topotecan, SN.38, etoposide, mitoxantrone, exatecan.mesylate, idarubicin, TAS.103, rubitecan, genz.644282, voreloxin, amsacrine",2.53017798402184,1.01502287358451,TRUE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",-0.51384,-1.27,0.196,1172,0.511,"taltobulin, oxibendazole, mebendazole, paclitaxel, docetaxel, fenbendazole, vinblastine, verubulin, fosbretabulin, BNC105, epothilone.b",0.707743928643524,0.291579099865287,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",-0.30908,-0.766,0.763,1027,0.977,"aminopurvalanol.a, dasatinib, UNC2250, tyrphostin.AG.99, bafetinib, cabozantinib, NVP.TAE226, AMG.208",0.11747546204512,0.0101054362812269,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",0.27516,0.753,0.73,125,0.968,"orantinib, AEE788, cediranib, PD.173074, lenvatinib, ZM.306416, BMS.690514",0.136677139879544,0.0141246426916063,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",0.4202,1.16,0.293,203,0.771,"maxacalcitol, paricalcitol, alfacalcidol",0.533132379645891,0.112945621949043,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.64054,1.58,0.0663,311,0.504,"erlotinib, WZ8040, OSI.420, osimertinib, PD.168393, pelitinib, BIBU.1361, icotinib, CP.724714, canertinib, BMS.690514, afatinib, dacomitinib, gefitinib, XL.647, tyrphostin.AG.1478, AZD8931, ARRY.334543, rociletinib, AEE788, vandetanib, BIBX.1382, PD.153035, lapatinib, poziotinib, CNX.2006",1.17848647159523,0.297569463554475,FALSE
+"H1299","Pearson.est","Abl kinase inhibitor",0.20663,0.504,0.984,499,0.978,"ZM.306416, imatinib, KW.2449, bosutinib, metatinib",0.00700490156865849,0.00966114521239857,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.38866,-1.01,0.423,1322,0.686,"nicotine, xanomeline",0.373659632624958,0.163675884293248,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",0.25279,0.623,0.917,375,0.982,"darifenacin, diphemanil, dicycloverine",0.0376306643299789,0.00788851221305034,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",0.84647,2.11,0,152,0.0159,"CGS.15943, SCH.58261, MRS.1220, PSB.1115",Inf,1.79860287567955,TRUE
+"H1299","Pearson.est","adrenergic receptor agonist",0.32889,0.811,0.699,560,0.953,"oxymetazoline, A61603, isoetharine, clenbuterol, methyldopa, buphenine, isoxsuprine, metaraminol",0.155522824254319,0.0209070993616736,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",0.26757,0.668,0.832,107,1,"atenolol...., dronedarone, RS.17053",0.0798766737092761,0,FALSE
+"H1299","Pearson.est","AKT inhibitor",0.55536,1.37,0.146,266,0.489,"CCT128930, palomid.529, GSK2110183, AZD5363",0.835647144215563,0.31069114087638,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.43565,1.08,0.367,388,0.752,"NVP.TAE684, GW.788388, SB.505124, AZD3463, alectinib, AP26113",0.435333935747911,0.123782159408358,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",-0.29994,-0.791,0.668,980,0.88,"RU.58841, nilutamide, enzalutamide",0.175223537524454,0.0555173278498314,FALSE
+"H1299","Pearson.est","antioxidant",0.25427,0.629,0.893,378,1,"benfotiamine, taurine",0.0491485411114536,0,FALSE
+"H1299","Pearson.est","AP inhibitor",0.39624,0.988,0.453,475,0.924,"birinapant, embelin, tanshinone.i, LCL.161",0.343901797987168,0.0343280287798933,FALSE
+"H1299","Pearson.est","ATPase inhibitor",-0.76696,-2.03,0.0026,1307,0.161,"rabeprazole, digitoxigenin, evodiamine, thonzonium, oligomycin.a, digoxin, k.strophanthidin",2.58502665202918,0.79317412396815,TRUE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.40706,-1.07,0.354,931,0.652,"MK.8745, hesperadin, tozasertib, GSK1070916, barasertib, SNS.314, ENMD.2076, CCT137690, TAK.901, MK.5108, AT.9283, AMG900, aurora.a.inhibitor.i",0.450996737974212,0.18575240426808,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.43398,-1.15,0.304,1144,0.671,"valnemulin, josamycin",0.517126416391246,0.173277479831008,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",-0.44109,-1.16,0.266,1262,0.702,"norfloxacin, lomefloxacin",0.575118363368933,0.153662887870195,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.39063,-1.03,0.365,964,0.686,"obatoclax, venetoclax, TW.37, ABT.737, gossypol",0.437707135543525,0.163675884293248,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.24282,-0.658,0.876,1176,0.951,"ponatinib, GZD824",0.0574958938319193,0.0218194830625861,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.56436,1.4,0.117,287,0.502,"lorazepam, nefiracetam, gamma.aminobutyric.acid, CGS.20625, zaleplon, piperazine",0.931814138253838,0.299296282854981,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",0.4892,1.2,0.255,729,0.632,"JQ1...., I.BET151, OTX015, I.BET.762, bromosporine",0.593459819566045,0.199282921717615,FALSE
+"H1299","Pearson.est","calcium channel blocker",0.25722,0.644,0.886,602,1,"cinnarazine, SR.33805, fendiline, efonidipine.monoethanolate, pranidipine, mibefradil",0.0525662781129492,0,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.46565,-1.21,0.231,1335,0.79,"ZK811752, UNBS.5162, SB.225002",0.636388020107856,0.102372908709559,FALSE
+"H1299","Pearson.est","CDK inhibitor",0.22298,0.552,0.959,551,1,"arcyriaflavin.a, indirubin, BMS.387032, kenpaullone, TG.02, indisulam, AZD5438, ribociclib, alvocidib, JNJ.7706621",0.0181813928293364,0,FALSE
+"H1299","Pearson.est","CHK inhibitor",0.33588,0.831,0.637,964,0.972,"LY2603618, CHIR.124, AZD7762, SCH.900776, SB.218078, LY2606368, PF.477736",0.19586056766465,0.0123337350737254,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",0.37036,0.92,0.561,424,0.977,"tryptanthrin, FR.122047, indoprofen, phenylbutazone, suxibuzone, ramifenazone, metoxibutropate, ketoprofen, pterostilbene, meloxicam, FK.3311, AM.404",0.251037138743839,0.0101054362812269,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",0.51937,1.28,0.191,244,0.564,"morin, PF.4981517, itraconazole",0.718966632752272,0.248720896016658,FALSE
+"H1299","Pearson.est","DNA alkylating agent",0.28248,0.709,0.8,261,1,"ifosfamide, streptozotocin, TH.302, dacarbazine",0.0969100130080564,0,FALSE
+"H1299","Pearson.est","DNA inhibitor",-0.46603,-1.23,0.229,1264,0.826,"mechlorethamine, carboplatin, carmustine, chlorambucil, sangivamycin, metronidazole",0.640164517660112,0.0830199526796178,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",0.53737,1.33,0.16,416,0.529,"azacitidine, RG108, SGI.1027, fdcyd",0.795880017344075,0.276544327964814,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",-0.51109,-1.35,0.165,1179,1,"adefovir.dipivoxil, foscarnet, trifluridine",0.782516055786094,0,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",0.26921,0.676,0.854,389,1,"estramustine.phosphate, capecitabine, altretamine, floxuridine",0.068542129310995,0,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",0.28252,0.707,0.818,326,1,"ziprasidone, acetophenazine, nemonapride, isofloxythepin, lurasidone, mesoridazine, amisulpride",0.087246696328677,0,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",-0.36767,-0.97,0.447,1067,0.664,"ethinyl.estradiol, equol, levonorgestrel, estrone",0.349692476868064,0.177831920631982,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.36938,-0.978,0.478,1385,0.68,"toremifene",0.320572103387881,0.167491087293764,FALSE
+"H1299","Pearson.est","FGFR inhibitor",0.39288,0.982,0.481,22,0.903,"PD.173074, orantinib",0.317854923626168,0.0443122496864942,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.33624,-0.868,0.591,1065,0.812,"GTP.14564, gilteritinib, ENMD.2076, TG.101348, ponatinib, sorafenib, dovitinib, tyrphostin.AG.1296",0.228412519118745,0.0904439707588247,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",0.34096,0.842,0.649,567,1,"betamethasone, rimexolone, flumethasone, fludroxycortide, clobetasol.propionate, triamcinolone.acetonide, prednisolone.hemisuccinate, prednisolone.acetate, deflazacort, ciclesonide, fluocinolone.acetonide, halobetasol.propionate, halcinonide, methylprednisolone, flumethasone.pivalate",0.187755303199631,0,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.48444,1.18,0.265,518,0.61,"latrepirdine, MTPG, SIB.1757, kynurenic.acid, CPP, LY456236, diazooxonorleucine, ACDPP",0.576754126063192,0.214670164989233,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.60282,1.51,0.0672,262,0.398,"LY2090314, indirubin, GSK.3.inhibitor.IX, CHIR.99021, kenpaullone",1.17263072694617,0.400116927926312,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",0.34382,0.868,0.606,494,1,"GSK1904529A, AZD3463, GSK1838705A, GW.441756",0.217527375833714,0,FALSE
+"H1299","Pearson.est","HCV inhibitor",0.67882,1.69,0.0342,319,0.31,"Ro.9187, daclatasvir, embelin, PSI.7976",1.46597389394386,0.508638306165727,FALSE
+"H1299","Pearson.est","HDAC inhibitor",0.63369,1.57,0.0576,445,0.445,"nexturastat.a, JNJ.26481585, tacedinaline, R306465, romidepsin, SB.939, panobinostat, pyroxamide, RG2833, entinostat, PCI.24781, M.344, resminostat, vorinostat, RGFP966, chidamide",1.23957751657679,0.351639989019068,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",0.52801,1.31,0.165,505,0.534,"terfenadine, levocetirizine, astemizole, tecastemizole, zolantidine, epinastine, ebastine, tiotidine, cyproheptadine, pheniramine, ICI.162846, ranitidine, BF2.649",0.782516055786094,0.272458742971444,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",-0.40693,-1.07,0.34,1001,0.652,"fluvastatin, atorvastatin, lovastatin",0.468521082957745,0.18575240426808,FALSE
+"H1299","Pearson.est","HSP inhibitor",0.33103,0.822,0.667,301,0.96,"alvespimycin, SNX.5422, tanespimycin, VER.49009",0.175874166083451,0.0177287669604316,FALSE
+"H1299","Pearson.est","JAK inhibitor",0.2235,0.548,0.966,450,0.998,"pacritinib, LY2784544, atiprimod, TG.02, PRT062070, WHI.P154",0.0150228735845067,0.000869458712628891,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.2731,-0.721,0.788,1225,0.93,"regorafenib, pazopanib, sorafenib, lenvatinib",0.103473782510445,0.0315170514460649,FALSE
+"H1299","Pearson.est","MDM inhibitor",0.71946,1.79,0.0159,302,0.3,"CGM097, RITA, serdemetan, nutlin.3",1.79860287567955,0.522878745280338,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.36941,0.913,0.547,141,0.958,"nobiletin, BIX.02188, arctigenin",0.262012673666569,0.0186344909214556,FALSE
+"H1299","Pearson.est","MET inhibitor",-0.66925,-1.77,0.0178,1419,0.226,"LY2801653",1.74957999769111,0.645891560852599,TRUE
+"H1299","Pearson.est","microtubule inhibitor",-0.40164,-1.09,0.33,1114,0.693,"cabazitaxel, D.64131, vinflunine, secnidazole, vinblastine",0.481486060122112,0.159266765388193,FALSE
+"H1299","Pearson.est","mTOR inhibitor",-0.23731,-0.617,0.908,1135,0.965,"WYE.354, MLN0128, voxtalisib, PKI.179, AZD2014, OSI.027, SB.2343, ku.0063794, PF.04691502",0.0419141514789149,0.0154726866562074,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",-0.23978,-0.61,0.903,1420,0.942,"EVP4593",0.0443122496864942,0.0259490972071227,FALSE
+"H1299","Pearson.est","opioid receptor agonist",-0.28628,-0.756,0.744,1353,0.906,"trimebutine",0.128427064454121,0.0428718023231869,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",0.43941,1.09,0.351,574,0.763,"SB.239063, SB.242235, VX.702, skepinone.l, TAK.715",0.454692883534176,0.11747546204512,FALSE
+"H1299","Pearson.est","PARP inhibitor",0.62121,1.53,0.0512,533,0.463,"endo.IWR.1, PJ.34, AG.14361, E7449, talazoparib, AZD2461, niraparib",1.29073003902417,0.334419008982047,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.31484,-0.818,0.676,1154,0.867,"axitinib, ponatinib, regorafenib, pazopanib, sorafenib, lenvatinib, linifanib, dovitinib, nintedanib",0.170053304058364,0.0619809025237897,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.37648,-0.978,0.448,1277,0.68,"GSK2830371, bis.maltolato.oxovanadium.IV., alexidine",0.348721986001856,0.167491087293764,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",0.704,1.73,0.0146,380,0.318,"GSK256066, papaverine, cilostamide, YM.976, zardaverine, anagrelide, trequinsin, EMD.53998",1.83564714421556,0.497572880015567,FALSE
+"H1299","Pearson.est","PI3K inhibitor",-0.21296,-0.563,0.95,1184,0.95,"voxtalisib, PKI.179, SB.2343, buparlisib, PF.04691502, GDC.0941",0.0222763947111523,0.0222763947111523,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.70854,-1.85,0.0212,1021,0.289,"GSK461364, BI.2536, HMN.214, rigosertib, NMS.1286937, volasertib, GW.843682X",1.67366413907125,0.539102157243452,FALSE
+"H1299","Pearson.est","potassium channel blocker",0.50103,1.24,0.219,85,0.579,"oleoylethanolamide",0.659555885159882,0.237321436272564,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",0.47121,1.18,0.257,213,0.61,"S26948, oleoylethanolamide, ciprofibrate",0.590066876668705,0.214670164989233,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",-0.45366,-1.19,0.243,1256,0.697,"norethindrone, levonorgestrel, tanaproget, nomegestrol.acetate",0.614393726401688,0.156767221901991,FALSE
+"H1299","Pearson.est","proteasome inhibitor",0.20756,0.522,0.958,479,0.991,"ixazomib.citrate, oprozomib, ONX.0914",0.0186344909214556,0.00392634551472468,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.41791,-1.1,0.338,1222,0.719,"bruceantin, mercaptopurine, anguidine, harringtonine, cycloheximide, clofoctol, chloramphenicol.palmitate",0.471083299722345,0.143271109617117,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",0.34052,0.832,0.672,158,1,"CP.724714, NVP.TAE226",0.172630726946175,0,FALSE
+"H1299","Pearson.est","RAF inhibitor",0.30092,0.737,0.777,104,1,"GDC.0879, CEP.32496",0.109578981199086,0,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",0.33661,0.837,0.666,209,1,"apatinib, vandetanib",0.176525770829699,0,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",-0.50954,-1.33,0.153,1432,0.775,"adapalene, fenretinide",0.815308569182401,0.11069829749369,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.45317,-1.19,0.268,1230,0.697,"hydroxyurea, triapine, pentostatin",0.571865205971211,0.156767221901991,FALSE
+"H1299","Pearson.est","serotonin receptor agonist",0.59688,1.49,0.0805,54,0.4,"ipsapirone, aripiprazole",1.09420411963213,0.397940008672038,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",0.50766,1.26,0.237,110,0.572,"SB.228357, aripiprazole, ziprasidone",0.625251653989896,0.242603971206976,FALSE
+"H1299","Pearson.est","sodium channel blocker",-0.25437,-0.663,0.888,1254,0.978,"oxcarbazepine, cibenzoline, benzocaine",0.051587034221399,0.00966114521239857,FALSE
+"H1299","Pearson.est","src inhibitor",0.60044,1.51,0.0824,268,0.398,"saracatinib, PP.2, PP.1, ZM.306416",1.08407278830288,0.400116927926312,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.68308,-1.82,0.0102,1268,0.232,"lanoconazole, posaconazole, sulconazole, chlormidazole",1.99139982823808,0.6345120151091,TRUE
+"H1299","Pearson.est","TGF beta receptor inhibitor",0.58713,1.47,0.0808,241,0.399,"LY2109761, D.4476, repsox",1.09258863922541,0.399027104313252,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",0.38111,0.937,0.534,345,0.974,"doxifluridine, capecitabine, raltitrexed, carmofur",0.272458742971444,0.0114410431213845,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.49658,-1.34,0.122,1162,0.872,"amsacrine, daunorubicin, idarubicin, voreloxin, TAS.103, SN.38, epirubicin, topotecan, dexrazoxane, etoposide.phosphate, doxorubicin, mitoxantrone",0.913640169325252,0.0594835150674328,FALSE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.49795,-1.3,0.168,1053,0.745,"ABT.751, indibulin, vincristine, epothilone.b, oxibendazole, verubulin, mebendazole, docetaxel, vinblastine, BNC105, paclitaxel, vindesine, fenbendazole",0.774690718274137,0.127843727251707,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",0.26385,0.651,0.876,209,1,"CP.724714, NVP.TAE226, apatinib, vandetanib",0.0574958938319193,0,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",0.24707,0.625,0.922,209,1,"PD.173074, orantinib, BMS.690514, vatalanib, XL.647, AEE788, vandetanib",0.0352690789463706,0,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.55076,1.39,0.116,400,0.485,"maxacalcitol, ercalcitriol, tacalcitol, calcitriol",0.935542010773082,0.314258261397736,FALSE
+"H1703","Pearson.est","EGFR inhibitor",0.32472,0.791,0.707,359,0.919,"WZ8040, BIBU.1361, TAK.285, erlotinib, icotinib, BMS.599626, tyrphostin.AG.1478, OSI.420, pelitinib, osimertinib, lapatinib, vandetanib, afatinib, gefitinib, PD.168393, rociletinib, canertinib",0.150580586203101,0.0366844886138887,FALSE
+"H1703","Pearson.est","Abl kinase inhibitor",0.3655,0.893,0.572,436,0.924,"imatinib, tozasertib, bafetinib, metatinib, KW.2449",0.242603971206976,0.0343280287798933,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",-0.46098,-1.19,0.255,1143,0.695,"nicotine, xanomeline",0.593459819566045,0.158015195409886,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.33306,-0.872,0.603,1112,1,"iododexetimide, hyoscyamine, methscopolamine",0.219682687859849,0,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",0.59302,1.51,0.0785,524,0.566,"CGS.15943, sulmazole, SCH.58261, MRS.1220",1.10513034325475,0.247183568811729,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",0.3026,0.757,0.759,480,0.929,"oxymetazoline, epinephrine, clenbuterol, isoxsuprine, terbutaline, A61603, norepinephrine",0.11975822410452,0.0319842860063582,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",-0.26373,-0.696,0.829,1147,0.986,"prazosin, atenolol......, naftidrofuryl, dihydroergocristine, metoprolol, atipamezole",0.0814454694497265,0.0061230850587888,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.61511,1.5,0.0855,97,0.461,"palomid.529, triciribine, uprosertib, CCT128930",1.06803388527183,0.336299074610352,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33758,0.856,0.627,254,0.945,"NVP.TAE684, GW.788388",0.202732459169284,0.0245681914907371,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",-0.23529,-0.607,0.919,1180,0.983,"flutamide, RU.58841",0.0366844886138887,0.00744648216786438,FALSE
+"H1703","Pearson.est","antioxidant",-0.57764,-1.49,0.101,1422,0.557,"trolox",0.995678626217357,0.254144804826271,FALSE
+"H1703","Pearson.est","AP inhibitor",0.51332,1.29,0.186,186,0.526,"embelin, LCL.161, GDC.0152",0.730487055782084,0.279014255846261,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.75157,-1.95,0.00465,1280,0.224,"blebbistatin...., NMS.873, evodiamine, digoxin, oligomycin.a, k.strophanthidin",2.33254704711005,0.649751981665837,TRUE
+"H1703","Pearson.est","Aurora kinase inhibitor",-0.26049,-0.665,0.874,1194,0.954,"TAK.901, CYC116, CCT129202, PHA.680632, AT.9283, aurora.a.inhibitor.i",0.058488567365597,0.0204516252959049,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.45731,-1.2,0.251,1427,0.742,"josamycin",0.600326278518962,0.129596094720973,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.38722,-1.02,0.404,1183,0.873,"norfloxacin, lomefloxacin, nadifloxacin",0.393618634889395,0.0589857562944303,FALSE
+"H1703","Pearson.est","BCL inhibitor",-0.47606,-1.23,0.234,1120,0.846,"obatoclax, TW.37, ABT.737, gossypol",0.630784142589857,0.0726296369609765,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.45954,1.12,0.332,420,0.709,"imatinib, tozasertib, bafetinib, metatinib",0.478861916295964,0.149353764816933,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.30115,0.749,0.778,487,0.921,"zaleplon, piperazine, CGS.20625, eprinomectin, lorazepam, ivermectin",0.109020403010311,0.0357403698031511,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",0.40894,1.04,0.364,507,0.787,"JQ1...., I.BET.762, bromosporine, OTX015",0.438898616350944,0.104025267640935,FALSE
+"H1703","Pearson.est","calcium channel blocker",-0.40474,-1.04,0.356,1010,0.893,"tetrandrine, fendiline, efonidipine.monoethanolate, mibefradil, carboxyamidotriazole",0.448550002027125,0.0491485411114536,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",0.36085,0.9,0.561,1,0.938,"navarixin",0.251037138743839,0.0277971616209356,FALSE
+"H1703","Pearson.est","CDK inhibitor",0.31086,0.765,0.746,503,0.939,"alvocidib, AZD5438, arcyriaflavin.a, kenpaullone, BMS.387032, PHA.793887, TG.02, JNJ.7706621, P276.00",0.127261172527331,0.0273344077338891,FALSE
+"H1703","Pearson.est","CHK inhibitor",0.54089,1.31,0.168,434,0.547,"LY2606368, SCH.900776, LY2603618, CHIR.124",0.774690718274137,0.262012673666569,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",0.40548,1,0.423,392,0.842,"indoprofen, amfenac, meloxicam, FK.3311, FR.122047, tryptanthrin, acetylsalicylsalicylic.acid, metoxibutropate, ramifenazone, curcumin, AM.404, aspirin",0.373659632624958,0.0746879085003505,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",0.38756,0.954,0.518,53,0.88,"itraconazole",0.285670240254767,0.0555173278498314,FALSE
+"H1703","Pearson.est","DNA alkylating agent",0.43589,1.08,0.361,501,0.759,"dacarbazine, TH.302, dianhydrogalactitol, streptozotocin, ifosfamide, cisplatin, estramustine, melphalan",0.442492798094342,0.11975822410452,FALSE
+"H1703","Pearson.est","DNA inhibitor",0.35448,0.9,0.559,12,0.938,"busulfan, nithiamide",0.252588192113577,0.0277971616209356,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",0.51136,1.28,0.195,365,0.517,"azacitidine, fdcyd, SGI.1027, decitabine",0.709965388637482,0.286509456906058,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",-0.31042,-0.804,0.692,447,0.886,"famciclovir, cephalomannine, cidofovir, idoxuridine, trifluridine, foscarnet, adefovir.dipivoxil, menadione",0.159893905543242,0.0525662781129492,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",0.25692,0.634,0.911,415,1,"altretamine, floxuridine, estramustine.phosphate, anisomycin, cisplatin",0.0404816230270017,0,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.31464,0.791,0.677,305,0.919,"isofloxythepin, ziprasidone, acetophenazine, oxiperomide, mesoridazine, amisulpride",0.169411331314856,0.0366844886138887,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",-0.31055,-0.821,0.662,1170,0.938,"levonorgestrel, estrone, erteberel",0.1791420105603,0.0277971616209356,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",0.34045,0.838,0.65,446,0.928,"raloxifene, toremifene",0.187086643357144,0.0324520237811379,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.3347,-0.856,0.596,1246,1,"dovitinib, nintedanib, erdafitinib",0.224753740259764,0,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",0.32847,0.825,0.655,122,0.903,"tandutinib, sunitinib, pacritinib",0.183758700008217,0.0443122496864942,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",-0.56219,-1.44,0.105,1133,0.561,"methylprednisolone, fluocinolone.acetonide, betamethasone, deflazacort, fluticasone.propionate, triamcinolone, clobetasol.propionate, flumethasone.pivalate, halcinonide, triamcinolone.acetonide, dexamethasone.acetate, desonide, beclomethasone.dipropionate, hydrocortisone",0.978810700930062,0.251037138743839,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.56339,1.42,0.107,102,0.461,"diazooxonorleucine, latrepirdine, SIB.1757, MTPG",0.97061622231479,0.336299074610352,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.57909,1.44,0.113,236,0.457,"AZD2858, GSK.3.inhibitor.IX, LY2090314, kenpaullone",0.94692155651658,0.34008379993015,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",-0.26509,-0.686,0.858,382,0.963,"GW.441756, GSK1838705A, lestaurtinib, AZD3463, GSK1904529A, danusertib, PHA.848125",0.0665127121512946,0.0163737128754655,FALSE
+"H1703","Pearson.est","HCV inhibitor",0.79174,1.97,0.00512,147,0.136,"embelin, Ro.9187, PSI.7976, daclatasvir",2.29073003902417,0.866461091629782,TRUE
+"H1703","Pearson.est","HDAC inhibitor",0.56074,1.4,0.126,363,0.41,"JNJ.26481585, tacedinaline, SB.939, R306465, panobinostat, M.344, romidepsin, vorinostat, RG2833, PCI.24781, nexturastat.a, dacinostat, ACY.1215",0.899629454882437,0.387216143280265,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.55756,1.41,0.115,440,0.418,"chloropyramine, terfenadine, levocetirizine, zolantidine, tiotidine, tecastemizole, ICI.162846, cimetidine, ranitidine, lafutidine, astemizole",0.939302159646388,0.378823718224965,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.32338,-0.842,0.641,1218,0.942,"atorvastatin, lovastatin",0.193141970481183,0.0259490972071227,FALSE
+"H1703","Pearson.est","HSP inhibitor",0.61147,1.54,0.0667,310,0.678,"VER.49009, XL888, guanidine, SNX.5422, tanespimycin, alvespimycin, SNX.2112, BIIB021, NVP.AUY922",1.17587416608345,0.168770306132937,FALSE
+"H1703","Pearson.est","JAK inhibitor",0.24143,0.6,0.922,174,0.978,"atiprimod, pacritinib, LY2784544",0.0352690789463706,0.00966114521239857,FALSE
+"H1703","Pearson.est","KIT inhibitor",0.58503,1.47,0.0903,459,0.481,"tandutinib, imatinib, sunitinib, telatinib, regorafenib, vatalanib, KI.8751, OSI.930, motesanib",1.04431224968649,0.317854923626168,FALSE
+"H1703","Pearson.est","MDM inhibitor",-0.27737,-0.735,0.778,1315,0.965,"AMG.232",0.109020403010311,0.0154726866562074,FALSE
+"H1703","Pearson.est","MEK inhibitor",0.28311,0.706,0.82,154,0.941,"BIX.02188, nobiletin, arctigenin",0.0861861476162833,0.0264103765727431,FALSE
+"H1703","Pearson.est","MET inhibitor",0.5104,1.26,0.207,712,0.5,"AMG458, INC.280, LY2801653, NVP.BVU972, PF.04217903, PHA.665752",0.684029654543082,0.301029995663981,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.21734,-0.557,0.948,1079,0.986,"triclabendazole, secnidazole, vinblastine, cytochalasin.b",0.0231916626619338,0.0061230850587888,FALSE
+"H1703","Pearson.est","mTOR inhibitor",0.20568,0.503,0.985,101,1,"palomid.529, PI.103, sirolimus",0.00656376950238827,0,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",-0.47456,-1.22,0.244,1429,0.773,"tyloxapol, EVP4593",0.612610173661271,0.111820506081675,FALSE
+"H1703","Pearson.est","opioid receptor agonist",0.33949,0.848,0.625,40,0.935,"salvinorin.a",0.204119982655925,0.0291883891274822,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.58292,1.46,0.0991,585,0.457,"CMPD.1, TAK.715, SB.239063, VX.702, skepinone.l, SB.242235",1.00392634551472,0.34008379993015,FALSE
+"H1703","Pearson.est","PARP inhibitor",0.60111,1.5,0.0717,264,0.461,"PJ.34, olaparib, niraparib, talazoparib",1.1444808443322,0.336299074610352,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.47468,1.18,0.284,366,0.617,"tandutinib, trapidil, imatinib, sunitinib, telatinib, orantinib, regorafenib, vatalanib, KI.8751",0.546681659952962,0.209714835966758,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.35279,-0.905,0.546,1278,1,"menadione, bis.maltolato.oxovanadium.IV., GSK2830371",0.262807357295263,0,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",0.28406,0.707,0.817,322,0.96,"YM.976, papaverine, GSK256066, EMD.53998",0.0877779434675845,0.0177287669604316,FALSE
+"H1703","Pearson.est","PI3K inhibitor",0.18908,0.474,0.983,390,1,"PI.103, CH5132799, pilaralisib, LY303511, TG.100713, PF.05212384, PIK.75, alpelisib",0.00744648216786438,0,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.60044,-1.55,0.0895,1153,0.56,"GW.843682X, volasertib, NMS.1286937",1.04817696468409,0.2518119729938,FALSE
+"H1703","Pearson.est","potassium channel blocker",0.69379,1.75,0.0165,141,0.307,"oleoylethanolamide, meglitinide",1.78251605578609,0.512861624522813,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",-0.32341,-0.85,0.607,1283,0.973,"fenofibrate, clofibrate",0.216811308924742,0.0118871597316481,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.70415,-1.82,0.0146,1170,0.282,"levonorgestrel, nomegestrol.acetate, tanaproget, norethindrone",1.83564714421556,0.549750891680639,FALSE
+"H1703","Pearson.est","proteasome inhibitor",0.69667,1.71,0.0212,348,0.313,"ixazomib.citrate, ixazomib, bortezomib, carfilzomib, delanzomib, ONX.0914",1.67366413907125,0.504455662453552,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.1827,-0.475,0.996,1036,0.989,"anguidine, cycloheximide, bruceantin, clindamycin.phosphate, florfenicol, clofoctol, harringtonine",0.00174066157630127,0.0048037084028206,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.53296,-1.41,0.114,1398,0.538,"PP.121, mubritinib",0.943095148663527,0.269217724333611,FALSE
+"H1703","Pearson.est","RAF inhibitor",0.56072,1.41,0.118,176,0.418,"dabrafenib, vemurafenib, CEP.32496, AZ.628, GDC.0879",0.928117992693875,0.378823718224965,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.69162,1.75,0.0152,311,0.307,"apatinib, sunitinib, regorafenib, vandetanib",1.81815641205523,0.512861624522813,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",-0.42714,-1.12,0.313,1321,0.778,"adapalene, adarotene, fenretinide",0.504455662453552,0.109020403010311,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",0.25187,0.625,0.898,409,0.995,"clofarabine, fludarabine.phosphate, fludarabine, gemcitabine, cladribine",0.0467236633326956,0.00217691925427455,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",-0.59237,-1.62,0.0679,1299,0.563,"aripiprazole, zolmitriptan, NAN.190",1.1681302257195,0.249491605148654,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",0.39091,0.982,0.461,160,0.849,"SB.228357, RS.16566, ziprasidone",0.336299074610352,0.0710923097560473,FALSE
+"H1703","Pearson.est","sodium channel blocker",-0.31453,-0.806,0.667,1118,0.922,"mepivacaine, oxcarbazepine, benzethonium, cibenzoline",0.175874166083451,0.0352690789463706,FALSE
+"H1703","Pearson.est","src inhibitor",0.41694,1.05,0.386,260,0.794,"saracatinib, PP.2, KX2.391",0.413412695328245,0.100179497572904,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.37949,-0.982,0.456,1160,0.902,"chlormidazole, sulconazole, posaconazole",0.341035157335565,0.0447934624580583,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.50843,1.26,0.209,227,0.5,"LY2109761, D.4476, repsox",0.679853713888946,0.301029995663981,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",0.61403,1.52,0.0802,181,0.629,"doxifluridine, carmofur, raltitrexed",1.09582563171584,0.201349354554731,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",0.35817,0.892,0.56,39,0.899,"licochalcone.a, genz.644282, exatecan.mesylate",0.2518119729938,0.0462403082667712,FALSE
+"H1703","Pearson.est","tubulin polymerization inhibitor",0.14999,0.377,0.998,369,0.999,"combretastatin.A.4, fosbretabulin, KX2.391, taltobulin, podophyllotoxin",0.000869458712628891,0.000434511774017692,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.24227,0.605,0.916,462,0.994,"apatinib, sunitinib, BMS.599626, tivantinib, regorafenib, vandetanib, bafetinib, AMG.208, rheochrysidin, AV.412",0.0381045263321496,0.00261361560268669,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",0.33684,0.828,0.664,366,0.922,"MGCD.265, sunitinib, lucitanib, telatinib, golvatinib, tivozanib, orantinib, regorafenib, vandetanib, PD.173074, vatalanib, KI.8751",0.177831920631982,0.0352690789463706,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.51401,1.3,0.176,298,0.535,"ercalcitriol, maxacalcitol, calcitriol, tacalcitol",0.75448733218585,0.271646217978772,FALSE
+"H460","Pearson.est","EGFR inhibitor",0.47508,1.23,0.215,431,0.81,"AZD8931, dacomitinib, CGP.52411, poziotinib, CNX.2006, canertinib, AST.1306, afatinib, tucatinib, WZ.3146, CP.724714, pelitinib, BMS.690514, salvianolic.acid.B, gefitinib, WZ8040, GW.583340, ARRY.334543, BIBX.1382, rociletinib, FERb.033",0.667561540084395,0.0915149811213502,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.39259,-1.01,0.443,1326,0.755,"KW.2449, GZD824, bafetinib",0.35359627377693,0.122053048370812,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.29863,-0.75,0.748,1320,0.811,"tremorine",0.126098402135539,0.090979145788844,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.72372,1.92,0.00677,204,0.178,"methscopolamine, iododexetimide, dicycloverine, hyoscyamine",2.16941133131486,0.749579997691106,TRUE
+"H460","Pearson.est","adenosine receptor antagonist",0.44253,1.2,0.214,603,0.811,"istradefylline, CGS.15943, theophylline, MRS.1220, sulmazole",0.669586226650809,0.090979145788844,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",0.31813,0.832,0.634,358,0.932,"lidamidine, xylazine, ritodrine, isoetharine, A61603, methyldopa",0.197910742118267,0.0305840876460186,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",0.35521,0.921,0.531,301,0.934,"RS.17053, atipamezole, atenolol...., prazosin, atenolol......, metoprolol, pindolol",0.274905478918531,0.0296531237699066,FALSE
+"H460","Pearson.est","AKT inhibitor",-0.30832,-0.793,0.699,1294,0.81,"triciribine, GDC.0068",0.155522824254319,0.0915149811213502,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4197,-1.1,0.316,1219,0.783,"AZD3463, crizotinib, alectinib",0.500312917381596,0.106238237942057,FALSE
+"H460","Pearson.est","androgen receptor antagonist",0.25489,0.662,0.831,592,0.984,"flutamide, RU.58841, nilutamide, enzalutamide, cyproterone.acetate",0.080398976215889,0.00700490156865849,FALSE
+"H460","Pearson.est","antioxidant",-0.44122,-1.15,0.309,1262,0.86,"chlorogenic.acid, mesna",0.510041520575165,0.0655015487564323,FALSE
+"H460","Pearson.est","AP inhibitor",0.33079,0.867,0.638,971,0.972,"embelin, idronoxil, tanshinone.i, LCL.161, birinapant, GDC.0152",0.195179321278838,0.0123337350737254,FALSE
+"H460","Pearson.est","ATPase inhibitor",0.4351,1.14,0.287,379,0.883,"k.strophanthidin, omeprazole, blebbistatin...., oligomycin.a, evodiamine, thonzonium",0.542118103266008,0.0540392964224314,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.40871,-1.05,0.378,1030,0.774,"ENMD.2076, AMG900, GSK1070916, danusertib, CCT137690, MK.8745, MK.5108, MLN.8054, hesperadin, KW.2449, PF.03814735",0.422508200162775,0.111259039317107,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.35567,-0.904,0.568,1357,0.792,"azalomycin.b, azithromycin",0.245651664288981,0.101274818410506,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",-0.36887,-0.962,0.473,1393,0.762,"finafloxacin, novobiocin",0.325138859262188,0.1180450286604,FALSE
+"H460","Pearson.est","BCL inhibitor",0.3741,1.01,0.414,330,0.864,"ABT.737, obatoclax, gossypol, navitoclax",0.382999658879101,0.0634862575211067,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.43596,-1.13,0.332,1332,0.854,"GZD824, bafetinib",0.478861916295964,0.068542129310995,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.37953,1.01,0.401,189,0.864,"temazepam, CL.218872, indiplon",0.396855627379818,0.0634862575211067,FALSE
+"H460","Pearson.est","bromodomain inhibitor",0.52805,1.37,0.157,504,0.814,"I.BET151, bromosporine, I.BET.762, OTX015",0.804100347590766,0.0893755951107988,FALSE
+"H460","Pearson.est","calcium channel blocker",0.52905,1.36,0.142,70,0.736,"mibefradil, efonidipine.monoethanolate, tetrandrine",0.847711655616944,0.133122185662501,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.46154,-1.16,0.275,1066,0.898,"ZK811752, UNBS.5162, RS.504393, navarixin",0.560667306169737,0.0467236633326956,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.30725,-0.789,0.682,989,0.776,"ribociclib, JNJ.7706621, abemaciclib, arcyriaflavin.a, BMS.265246, kenpaullone, PHA.848125, alvocidib, NU6027, AZD5438",0.166215625343521,0.110138278741812,FALSE
+"H460","Pearson.est","CHK inhibitor",-0.39615,-1.02,0.412,964,0.802,"SB.218078, SCH.900776, LY2603618, LY2606368",0.385102783966865,0.0958256317158365,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",-0.36854,-0.943,0.496,1147,0.77,"meloxicam, amfenac, FR.122047, aspirin, phenazone, curcumin, ramifenazone, indoprofen, suxibuzone, acetylsalicylsalicylic.acid",0.304518323509803,0.113509274827518,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",0.37629,0.978,0.465,336,0.894,"metyrapone, itraconazole, morin",0.332547047110046,0.0486624812040823,FALSE
+"H460","Pearson.est","DNA alkylating agent",-0.34644,-0.872,0.605,1105,0.753,"melphalan, dianhydrogalactitol, mitomycin.c, carboplatin, TH.302",0.218244625347531,0.123205023799299,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.53032,-1.36,0.156,1105,0.724,"melphalan, nithiamide, sangivamycin, valrubicin, carboplatin, teroxirone",0.806875401645538,0.140261433802853,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.48627,-1.27,0.215,1318,0.893,"azacitidine, decitabine",0.667561540084395,0.0491485411114536,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",0.64065,1.69,0.0285,199,0.484,"cidofovir, adefovir.dipivoxil, menadione, famciclovir",1.54515513999149,0.315154638355588,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.46508,-1.19,0.262,1142,0.956,"anisomycin, CB.10.277, mitomycin.c, altretamine, cyclocytidine, floxuridine",0.581698708680255,0.0195421077238999,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",0.39649,1.07,0.345,175,0.934,"nemonapride, remoxipride, lurasidone, mesoridazine, clebopride",0.462180904926726,0.0296531237699066,FALSE
+"H460","Pearson.est","estrogen receptor agonist",0.19759,0.518,0.964,361,1,"erteberel, ethinyl.estradiol",0.0159229660971692,0,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",0.6005,1.62,0.0458,11,0.52,"tamoxifen",1.33913452199613,0.283996656365201,FALSE
+"H460","Pearson.est","FGFR inhibitor",0.38891,1.02,0.415,392,0.941,"erdafitinib, orantinib, nintedanib, lenvatinib, lucitanib",0.381951903287907,0.0264103765727431,FALSE
+"H460","Pearson.est","FLT3 inhibitor",0.25235,0.664,0.865,263,1,"GTP.14564, TG.02, sorafenib, TG.101348, midostaurin",0.0629838925351858,0,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",0.54698,1.44,0.114,411,0.74,"hydrocortisone, piretanide, triamcinolone, halcinonide, triamcinolone.acetonide, difluprednate, deflazacort, dexamethasone.acetate, beclomethasone.dipropionate, flumethasone.pivalate, prednisolone.hemisuccinate, betamethasone",0.943095148663527,0.130768280269024,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.25971,0.687,0.832,430,1,"LY456236, kynurenic.acid, JNJ.16259685, IEM1754, CPP",0.0798766737092761,0,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.30809,-0.789,0.717,980,0.776,"AZD2858, tideglusib, kenpaullone, LY2090314",0.1444808443322,0.110138278741812,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.71854,-1.8,0.0123,1117,0.214,"danusertib, lestaurtinib, AZD3463, GSK1838705A, PHA.848125, GW.441756",1.9100948885606,0.669586226650809,TRUE
+"H460","Pearson.est","HCV inhibitor",-0.3528,-0.926,0.523,1081,0.776,"Ro.9187, daclatasvir",0.281498311132726,0.110138278741812,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.40426,-1.05,0.377,1017,0.774,"M.344, dacinostat, JNJ.26481585, AR.42, romidepsin, PCI.24781, panobinostat, entinostat, givinostat, R306465, tacedinaline, chidamide",0.423658649794207,0.111259039317107,FALSE
+"H460","Pearson.est","histamine receptor antagonist",-0.25437,-0.654,0.883,1128,0.87,"levocetirizine, pheniramine, astemizole, ranitidine, terfenadine, zolantidine",0.0540392964224314,0.0604807473813815,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.32412,0.861,0.619,261,0.945,"lovastatin, atorvastatin",0.208309350979882,0.0245681914907371,FALSE
+"H460","Pearson.est","HSP inhibitor",-0.42422,-1.11,0.309,927,0.852,"tanespimycin, XL888, VER.49009, NMS.E973, ganetespib, NVP.AUY922, SNX.2112, BIIB021, PU.H71, SNX.5422",0.510041520575165,0.0695604052332999,FALSE
+"H460","Pearson.est","JAK inhibitor",0.17339,0.465,0.985,523,1,"TG.02, TG.101348, TG.101209, AT.9283, LY2784544, AZD1480, atiprimod, filgotinib, CEP.33779",0.00656376950238827,0,FALSE
+"H460","Pearson.est","KIT inhibitor",0.32605,0.847,0.62,333,0.937,"cediranib, telatinib, sorafenib, midostaurin, lenvatinib, motesanib",0.207608310501746,0.0282604091122217,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.71116,-1.83,0.00749,1266,0.26,"CGM097, serdemetan, idasanutlin, nutlin.3",2.12551818230053,0.585026652029182,FALSE
+"H460","Pearson.est","MEK inhibitor",-0.58352,-1.52,0.0669,1057,0.477,"nobiletin, arctigenin, selumetinib, AZD8330, PD.198306, TAK.733, cobimetinib, MEK162, refametinib, PD.98059, PD.184352, AS.703026, Ro.4987655, PD.0325901, trametinib",1.17457388223218,0.321481620959886,FALSE
+"H460","Pearson.est","MET inhibitor",-0.34951,-0.9,0.553,504,0.774,"AMG458, LY2801653, NVP.BVU972, INC.280, PHA.665752, PF.04217903",0.257274868695302,0.111259039317107,FALSE
+"H460","Pearson.est","microtubule inhibitor",0.31506,0.808,0.669,213,0.911,"triclabendazole, cytochalasin.b, colchicine",0.174573882232177,0.0404816230270017,FALSE
+"H460","Pearson.est","mTOR inhibitor",-0.43514,-1.1,0.34,1225,0.783,"AZD2014, MLN0128, sirolimus, NVP.BEZ235, PI.103, ku.0063794, LY303511, PP242",0.468521082957745,0.106238237942057,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",0.43332,1.13,0.292,245,0.845,"tyloxapol, parthenolide, IKK.2.inhibitor.V",0.534617148551582,0.0731432910503077,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.27484,-0.717,0.813,1008,0.835,"salvinorin.a, spiradoline, BW.180C",0.0899094544059319,0.0783135245163979,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",-0.42168,-1.08,0.355,1193,0.786,"CMPD.1, VX.702",0.449771646944906,0.104577453960592,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.68161,-1.73,0.0235,1348,0.261,"niraparib, talazoparib, olaparib",1.62893213772826,0.583359492661719,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.27761,0.728,0.779,333,0.981,"linifanib, orantinib, telatinib, nintedanib, sorafenib, lenvatinib, motesanib",0.108462542327436,0.0083309926200515,FALSE
+"H460","Pearson.est","phosphatase inhibitor",0.33263,0.875,0.59,196,0.996,"GSK2830371, menadione, BVT.948",0.229147988357856,0.00174066157630127,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",-0.45,-1.17,0.284,1070,0.937,"zardaverine, cilostamide, papaverine, EMD.53998, GSK256066, YM.976, trequinsin",0.546681659952962,0.0282604091122217,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.2647,-0.675,0.836,1337,0.867,"NVP.BEZ235, PIK.75, PI.103, LY303511",0.0777937225609836,0.0619809025237897,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.62322,-1.59,0.068,1073,0.398,"GW.843682X, NMS.1286937, BI.2536, HMN.214, GSK461364",1.16749108729376,0.400116927926312,FALSE
+"H460","Pearson.est","potassium channel blocker",-0.33683,-0.867,0.615,1297,0.74,"oleoylethanolamide, meglitinide",0.211124884224583,0.130768280269024,FALSE
+"H460","Pearson.est","PPAR receptor agonist",0.57444,1.52,0.0744,210,0.652,"GW.501516, fenofibrate, pterostilbene, S26948",1.12842706445412,0.18575240426808,FALSE
+"H460","Pearson.est","progesterone receptor agonist",0.48928,1.32,0.174,456,0.742,"norgestrel, norethindrone, melengestrol.acetate, tanaproget, nomegestrol.acetate",0.7594507517174,0.129596094720973,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.18125,0.465,0.99,1187,1,"carfilzomib, oprozomib, ONX.0914, bortezomib, ixazomib.citrate, MG.132, ixazomib, delanzomib",0.00436480540245009,0,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.39369,-0.987,0.491,1059,0.742,"homoharringtonine, azomycin..2.nitroimidazole., chloramphenicol.palmitate, emetine, cycloheximide, thiostrepton, brefeldin.a",0.308918507877032,0.129596094720973,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",0.39404,1.06,0.344,574,0.9,"CP.724714, rheochrysidin, PP.121, mubritinib, AV.412",0.46344155742847,0.0457574905606751,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.32537,-0.841,0.611,975,0.759,"AZ.628, dabrafenib, CEP.32496, RAF265, regorafenib, vemurafenib, SB.590885, LGX818",0.213958789757446,0.11975822410452,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.34205,-0.876,0.594,990,0.768,"sunitinib, cabozantinib, regorafenib",0.226213555018806,0.114638779968488,FALSE
+"H460","Pearson.est","retinoid receptor agonist",0.31141,0.819,0.7,14,0.922,"fenretinide",0.154901959985743,0.0352690789463706,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",-0.56772,-1.45,0.087,1239,0.572,"hydroxyurea, clofarabine, cladribine, fludarabine, fludarabine.phosphate",1.06048074738138,0.242603971206976,FALSE
+"H460","Pearson.est","serotonin receptor agonist",-0.3873,-0.989,0.442,1447,0.766,"aripiprazole",0.354577730650908,0.115771230367396,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.35302,-0.893,0.568,1061,0.762,"RS.16566, SB.216641, SB.228357, ziprasidone, SB.200646, aripiprazole",0.245651664288981,0.1180450286604,FALSE
+"H460","Pearson.est","sodium channel blocker",0.21036,0.575,0.946,360,1,"cibenzoline, benzethonium, lappaconite, mepivacaine",0.0241088635982073,0,FALSE
+"H460","Pearson.est","src inhibitor",0.49438,1.3,0.193,71,0.711,"ZM.306416, PP.1",0.714442690992226,0.148130399270234,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.39597,-1.01,0.43,1296,0.755,"ketoconazole, lanoconazole",0.366531544420413,0.122053048370812,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",0.85937,2.27,0,123,0.00516,"adaprev, SB.525334, SB.431542, repsox",Inf,2.28735029837279,TRUE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.73562,-1.85,0.00549,1382,0.432,"carmofur, raltitrexed",2.26042765554991,0.364516253185088,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.62289,-1.64,0.038,1123,0.361,"beta.lapachone, etoposide, idarubicin, irinotecan, topotecan, voreloxin, SN.38, TAS.103, nemorubicin, valrubicin, rubitecan, camptothecin, amonafide, exatecan.mesylate, mitoxantrone, amsacrine, genz.644282",1.42021640338319,0.442492798094342,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.48443,-1.25,0.212,1068,0.865,"vinblastine, oxibendazole, ABT.751, podophyllotoxin, fosbretabulin, epothilone.b, verubulin, KX2.391, taltobulin, combretastatin.A.4, mebendazole, BNC105",0.673664139071249,0.0629838925351858,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",0.13953,0.371,1,340,0.999,"GTP.14564, sorafenib, CP.724714, UNC2250, rheochrysidin",0,0.000434511774017692,FALSE
+"H460","Pearson.est","VEGFR inhibitor",0.3571,0.952,0.502,392,0.91,"ZM.306416, cediranib, linifanib, orantinib, telatinib, nintedanib, sorafenib, BMS.690514, lenvatinib, semaxanib, motesanib, golvatinib, lucitanib",0.299296282854981,0.0409586076789064,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",0.29641,0.783,0.696,157,0.922,"alfacalcidol, paricalcitol",0.157390760389438,0.0352690789463706,FALSE
+"H520","Pearson.est","EGFR inhibitor",0.27517,0.704,0.818,418,0.938,"WZ.3146, vandetanib, WZ8040, CNX.2006, pelitinib, CGP.52411, icotinib, canertinib, AST.1306, BMS.690514, afatinib, rociletinib, tyrphostin.AG.494, BIBU.1361, erlotinib, PD.168393, dacomitinib, poziotinib, BIBX.1382",0.087246696328677,0.0277971616209356,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",0.49309,1.28,0.197,230,0.615,"flumatinib, KW.2449, ZM.306416, dasatinib",0.705533773838407,0.211124884224583,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",0.31363,0.818,0.663,494,0.948,"xanomeline, nefiracetam, nicotine",0.178486471595227,0.0231916626619338,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",-0.33074,-0.894,0.543,1403,0.705,"diphemanil",0.265200170411153,0.151810883008601,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",0.57047,1.45,0.109,491,0.582,"theophylline, MRS.1220, sulmazole, istradefylline, CGS.15943",0.962573502059376,0.235077015350112,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.49369,1.26,0.211,243,0.574,"oxymetazoline, norepinephrine, terbutaline, midodrine, buphenine, A61603, clenbuterol",0.675717544702307,0.241088107602027,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",-0.31245,-0.814,0.666,1303,0.81,"naftidrofuryl, prazosin, idazoxan, vincamine",0.176525770829699,0.0915149811213502,FALSE
+"H520","Pearson.est","AKT inhibitor",0.4088,1.06,0.397,192,0.69,"AT7867, palomid.529, CCT128930, MK.2206",0.401209493236885,0.161150909262745,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.39632,-1.04,0.379,1275,0.728,"AZD3463, CEP.37440, crizotinib",0.421360790031928,0.137868620686963,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.4801,1.21,0.232,253,0.633,"bicalutamide, RU.58841",0.6345120151091,0.198596289982645,FALSE
+"H520","Pearson.est","antioxidant",0.41932,1.06,0.362,15,0.69,"benfotiamine",0.441291429466834,0.161150909262745,FALSE
+"H520","Pearson.est","AP inhibitor",0.43649,1.12,0.319,519,0.702,"birinapant, embelin, GDC.0152",0.496209316942819,0.153662887870195,FALSE
+"H520","Pearson.est","ATPase inhibitor",-0.44172,-1.17,0.269,1260,0.594,"omeprazole, NMS.873, digitoxigenin, rabeprazole, digoxin",0.570247719997592,0.226213555018806,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",0.18436,0.473,0.974,469,0.986,"KW.2449, CYC116, ZM.447439, hesperadin, GSK1070916, MLN.8054, SNS.314, CCT129202, alisertib",0.0114410431213845,0.0061230850587888,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.39851,-1.05,0.387,1039,0.745,"radezolid, tedizolid, dirithromycin, azithromycin, azalomycin.b",0.412289034981089,0.127843727251707,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.62164,1.56,0.0659,352,0.561,"trovafloxacin, novobiocin, sparfloxacin, nadifloxacin, finafloxacin",1.18111458540599,0.251037138743839,FALSE
+"H520","Pearson.est","BCL inhibitor",0.46703,1.2,0.257,608,0.618,"ABT.737, TW.37, HA14.1, navitoclax, gossypol, obatoclax, oridonin",0.590066876668705,0.209011524911184,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",0.30858,0.779,0.712,230,0.927,"flumatinib, dasatinib",0.147520006363144,0.0329202658555029,FALSE
+"H520","Pearson.est","benzodiazepine receptor agonist",0.52092,1.33,0.152,374,0.73,"lorazepam, temazepam, CGS.20625, gamma.aminobutyric.acid, indiplon, nefiracetam",0.818156412055227,0.136677139879544,FALSE
+"H520","Pearson.est","bromodomain inhibitor",0.27184,0.701,0.805,1056,0.918,"bromosporine, I.BET151, PFI.1, OTX015, I.BET.762, JQ1....",0.0942041196321315,0.0371573187987575,FALSE
+"H520","Pearson.est","calcium channel blocker",0.2329,0.612,0.909,56,0.93,"efonidipine.monoethanolate",0.0414361167780325,0.0315170514460649,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",-0.35154,-0.937,0.527,1011,0.683,"UNBS.5162, navarixin, SB.225002, PF.04136309, ZK811752",0.278189384787453,0.165579296318467,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.54737,-1.43,0.11,1016,0.417,"AT.7519, indisulam, ribociclib, PHA.793887, dinaciclib, JNJ.7706621, alvocidib, abemaciclib, arcyriaflavin.a, NU6027, AZD5438, BMS.265246, BMS.387032, PHA.848125",0.958607314841775,0.379863945026242,FALSE
+"H520","Pearson.est","CHK inhibitor",0.36397,0.957,0.489,43,0.836,"AZD7762",0.31069114087638,0.0777937225609836,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",0.26133,0.649,0.877,247,0.936,"ketoprofen, metoxibutropate, piroxicam, indoprofen, tryptanthrin",0.0570004066339595,0.0287241512618947,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",0.67597,1.7,0.0276,186,0.429,"itraconazole, cobicistat, eplerenone",1.55909091793478,0.367542707815276,FALSE
+"H520","Pearson.est","DNA alkylating agent",-0.38903,-1.03,0.384,1067,0.711,"temozolomide, satraplatin, cyclophosphamide, melphalan, dacarbazine, mitomycin.c",0.415668775632469,0.148130399270234,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.59418,-1.57,0.0719,1216,0.444,"busulfan, melphalan, nimorazole, bendamustine, teroxirone, sangivamycin, metronidazole",1.14327110961712,0.35261702988538,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",-0.37274,-0.983,0.441,1154,0.768,"azacitidine, SGI.1027, fdcyd, decitabine",0.355561410532161,0.114638779968488,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",0.55304,1.46,0.0993,325,0.64,"cephalomannine, menadione, cidofovir, famciclovir",1.00305075150462,0.193820026016113,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",-0.36911,-0.975,0.47,1222,0.751,"cyclocytidine, floxuridine, enocitabine, nelarabine, mitomycin.c",0.327902142064283,0.124360062995832,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",0.42886,1.1,0.341,224,0.674,"nemonapride, UH.232...., acetophenazine, clebopride, raclopride, lurasidone",0.467245621007502,0.17134010346468,FALSE
+"H520","Pearson.est","estrogen receptor agonist",0.31639,0.792,0.674,36,0.963,"PPT",0.17134010346468,0.0163737128754655,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",-0.57345,-1.49,0.0839,1025,0.409,"tamoxifen, toremifene, raloxifene",1.0762380391713,0.388276691992658,FALSE
+"H520","Pearson.est","FGFR inhibitor",-0.51548,-1.36,0.138,1263,0.448,"nintedanib, dovitinib, lenvatinib, regorafenib",0.860120913598763,0.348721986001856,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.35827,-0.946,0.496,1179,0.692,"ENMD.2076, sorafenib, lestaurtinib, pacritinib, tyrphostin.AG.1296, dovitinib, TG.101348",0.304518323509803,0.159893905543242,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",0.36701,0.952,0.508,404,0.814,"piretanide, hydrocortisone, deflazacort, prednisolone.hemisuccinate, flumethasone.pivalate, triamcinolone, clobetasol.propionate, fludroxycortide, prednisolone",0.294136287716081,0.0893755951107988,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",0.50061,1.3,0.187,227,0.734,"SIB.1757, JNJ.16259685, latrepirdine, kynurenic.acid, LY456236",0.728158393463501,0.134303940083929,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.50873,1.28,0.194,583,0.615,"LY2090314, indirubin, CHIR.99021, CHIR.98014, TWS.119, GSK.3.inhibitor.IX",0.712198270069774,0.211124884224583,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.68015,-1.73,0.0364,1257,0.242,"lestaurtinib, AZD3463, GW.441756, PHA.848125, danusertib",1.43889861635094,0.616184634019569,TRUE
+"H520","Pearson.est","HCV inhibitor",0.45279,1.15,0.297,71,0.678,"Ro.9187",0.527243550682788,0.168770306132937,FALSE
+"H520","Pearson.est","HDAC inhibitor",0.25877,0.663,0.878,336,0.943,"romidepsin, RG2833, RGFP966, pyroxamide, belinostat, nexturastat.a, mocetinostat, JNJ.26481585",0.0565054840938974,0.0254883072626717,FALSE
+"H520","Pearson.est","histamine receptor antagonist",0.61981,1.56,0.0658,254,0.561,"chloropyramine, epinastine, BF2.649, famotidine, ICI.162846, terfenadine, tiotidine, pheniramine, lafutidine",1.18177410638604,0.251037138743839,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.71945,1.85,0.0057,391,0.488,"pitavastatin, atorvastatin, fluvastatin, mevastatin, lovastatin",2.24412514432751,0.311580177997289,FALSE
+"H520","Pearson.est","HSP inhibitor",0.27805,0.724,0.776,129,0.96,"KW.2478, VER.49009",0.110138278741812,0.0177287669604316,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.48403,-1.26,0.212,1257,0.509,"lestaurtinib, LY2784544, pacritinib, baricitinib, TG.101348",0.673664139071249,0.293282217663241,FALSE
+"H520","Pearson.est","KIT inhibitor",-0.2872,-0.749,0.741,1192,0.886,"sorafenib, OSI.930, pazopanib, lenvatinib, regorafenib",0.130181792020672,0.0525662781129492,FALSE
+"H520","Pearson.est","MDM inhibitor",-0.22047,-0.583,0.924,1169,0.934,"nutlin.3, idasanutlin",0.0343280287798933,0.0296531237699066,FALSE
+"H520","Pearson.est","MEK inhibitor",0.37734,0.972,0.479,468,0.837,"U.0126, PD.184352, TAK.733, BIX.02188, arctigenin, PD.98059, refametinib, MEK1.2.inhibitor, PD.318088, AZD8330",0.319664486585437,0.07727454200674,FALSE
+"H520","Pearson.est","MET inhibitor",-0.26214,-0.7,0.793,378,0.856,"LY2801653, AMG458, NVP.BVU972, PF.04217903, PHA.665752, INC.280",0.100726812682396,0.0675262353228468,FALSE
+"H520","Pearson.est","microtubule inhibitor",-0.36534,-0.958,0.492,955,0.753,"secnidazole, cabazitaxel, colchicine, vinblastine, podophyllotoxin, vinflunine, D.64131",0.30803489723264,0.123205023799299,FALSE
+"H520","Pearson.est","mTOR inhibitor",-0.51302,-1.34,0.164,1038,0.446,"PKI.179, WAY.600, PF.04691502, sirolimus, GSK2126458, OSI.027, XL388, voxtalisib, WYE.354, NVP.BEZ235, WYE.125132, PP242, ku.0063794, AZD8055, MLN0128, AZD2014",0.785156151952302,0.350665141287858,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",0.27931,0.728,0.79,305,0.981,"BAY.11.7085, IKK.2.inhibitor.V, tyloxapol",0.102372908709559,0.0083309926200515,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.57142,1.48,0.0904,4,0.686,"cebranopadol",1.04383156952464,0.163675884293248,FALSE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.66,-1.73,0.033,1447,0.242,"talmapimod",1.48148606012211,0.616184634019569,TRUE
+"H520","Pearson.est","PARP inhibitor",-0.35235,-0.914,0.519,1148,0.696,"niraparib, olaparib, PJ.34",0.284832642151542,0.157390760389438,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.26266,-0.702,0.797,1192,0.877,"sorafenib, crenolanib, pazopanib, nintedanib, dovitinib, lenvatinib, regorafenib",0.0985416786038876,0.0570004066339595,FALSE
+"H520","Pearson.est","phosphatase inhibitor",0.27437,0.717,0.793,338,0.945,"menadione, mycophenolate.mofetil, CID.5458317",0.100726812682396,0.0245681914907371,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",0.56915,1.44,0.11,487,0.539,"papaverine, anagrelide, avanafil, GSK256066, YM.976, enoximone, EMD.53998",0.958607314841775,0.268411234813261,FALSE
+"H520","Pearson.est","PI3K inhibitor",-0.36408,-0.947,0.492,1128,0.716,"PIK.75, GSK2126458, alpelisib, voxtalisib, CUDC.907, NVP.BEZ235, PI3K.IN.2, YM.201636, idelalisib, CH5132799",0.30803489723264,0.145086977692144,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.81935,-2.16,0,1262,0.0304,"GSK461364, HMN.214, volasertib, BI.2536, GW.843682X, NMS.1286937",Inf,1.51712641639125,TRUE
+"H520","Pearson.est","potassium channel blocker",0.32672,0.839,0.66,522,0.94,"meglitinide, dofetilide, ibutilide, mepivacaine",0.180456064458131,0.0268721464003014,FALSE
+"H520","Pearson.est","PPAR receptor agonist",0.49267,1.26,0.209,237,0.574,"S26948, fenofibrate",0.679853713888946,0.241088107602027,FALSE
+"H520","Pearson.est","progesterone receptor agonist",0.3317,0.845,0.629,287,0.96,"norgestrel, tanaproget, norethindrone",0.201349354554731,0.0177287669604316,FALSE
+"H520","Pearson.est","proteasome inhibitor",-0.22847,-0.606,0.931,329,0.939,"ixazomib.citrate, ONX.0914, oprozomib, bortezomib, carfilzomib, ixazomib, MG.132, delanzomib",0.0310503190186574,0.0273344077338891,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.56568,-1.48,0.0987,1231,0.383,"emetine, clofoctol, anguidine, tedizolid.phosphate, harringtonine, bruceantin, homoharringtonine, chloramphenicol.palmitate",1.00568284733036,0.416801226031377,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.27014,-0.708,0.812,1151,0.92,"BMS.599626, mubritinib, tyrphostin.A9",0.0904439707588247,0.0362121726544447,FALSE
+"H520","Pearson.est","RAF inhibitor",-0.56474,-1.54,0.0901,1060,0.377,"TAK.632, vemurafenib, sorafenib, SB.590885, RAF265, LGX818, AZ.628, regorafenib",1.04527520902094,0.423658649794207,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.42452,-1.14,0.297,1192,0.614,"sorafenib, regorafenib",0.527243550682788,0.211831628858832,FALSE
+"H520","Pearson.est","retinoid receptor agonist",-0.49849,-1.31,0.188,1004,0.458,"CD.437, bexarotene, adapalene, tamibarotene, adarotene, AM.580",0.72584215073632,0.339134521996131,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.36279,-0.949,0.511,1187,0.74,"hydroxyurea, fludarabine.phosphate, pentostatin",0.291579099865287,0.130768280269024,FALSE
+"H520","Pearson.est","serotonin receptor agonist",0.66534,1.71,0.0229,1,0.601,"aripiprazole",1.64016451766011,0.22112552799726,FALSE
+"H520","Pearson.est","serotonin receptor antagonist",0.5068,1.29,0.198,224,0.695,"aripiprazole, RS.16566, lerisetron, tropisetron, lurasidone",0.703334809738469,0.158015195409886,FALSE
+"H520","Pearson.est","sodium channel blocker",0.30496,0.783,0.717,332,0.948,"quinidine, lappaconite, ajmaline, A.803467, benzethonium",0.1444808443322,0.0231916626619338,FALSE
+"H520","Pearson.est","src inhibitor",0.35015,0.912,0.545,230,0.861,"PP.2, ZM.306416, dasatinib",0.263603497723358,0.0649968485463452,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",-0.68719,-1.85,0.0104,1407,0.285,"chlormidazole, ketoconazole, lanoconazole",1.98296666070122,0.54515513999149,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",0.425,1.1,0.323,644,0.674,"D.4476, SB.431542, repsox, LY2109761",0.490797477668897,0.17134010346468,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",-0.63628,-1.73,0.0277,1086,0.242,"raltitrexed, trifluridine, carmofur, ftorafur",1.55752023093555,0.616184634019569,TRUE
+"H520","Pearson.est","topoisomerase inhibitor",-0.45754,-1.18,0.263,1199,0.611,"amsacrine, camptothecin, genz.644282, nemorubicin, etoposide.phosphate, topotecan, mitoxantrone, dexrazoxane, SN.38",0.580044251510242,0.213958789757446,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.53365,-1.41,0.123,911,0.41,"docetaxel, vindesine, vinorelbine, paclitaxel, dolastatin.10, vincristine, epothilone.b, vinblastine, combretastatin.A.4, fenbendazole, CYT.997, oxibendazole, verubulin, podophyllotoxin, plinabulin, ABT.751, BNC105, taltobulin, KX2.391, mebendazole",0.910094888560602,0.387216143280265,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",-0.27742,-0.707,0.791,1143,0.895,"tyrphostin.AG.99, BMS.599626, mubritinib, tyrphostin.A9, sorafenib, bafetinib, tivantinib, regorafenib",0.101823516502323,0.048176964684088,FALSE
+"H520","Pearson.est","VEGFR inhibitor",0.24159,0.618,0.91,365,0.947,"orantinib, SU014813, vatalanib, ZM.306416, semaxanib, vandetanib, motesanib, MK.2461, MGCD.265, BMS.690514, cediranib, axitinib, KI.8751, SAR131675",0.0409586076789064,0.0236500209967266,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",-0.58618,-1.54,0.0862,1248,0.377,"calcitriol, maxacalcitol, doxercalciferol",1.06449273417529,0.423658649794207,FALSE
diff --git a/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren_prot_NSCLC/DMEA/DMEA_venn_diagram.pdf
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diff --git a/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_correlation_matrix.pdf b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_correlation_matrix.pdf
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+++ b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_interactive_network.graph.html
@@ -0,0 +1,5318 @@
+<!DOCTYPE html>
+<html>
+<head>
+<meta charset="utf-8" />
+<title>visNetwork</title>
+<script>(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var el = scope.querySelector(selector);
+    if (el === null) {
+      return null;
+    } else {
+      return window.HTMLWidgets.getInstance(el);
+    }
+  };
+
+  // Finds all elements in the scope that match the selector, and
+  // returns the HTMLWidget instances (i.e. the return values of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with the elements, in an array. If elements that
+  // match the selector don't have an associated HTMLWidget
+  // instance, the returned array will contain nulls.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.findAll = function(scope, selector) {
+    if (arguments.length == 1) {
+      selector = scope;
+      scope = document;
+    }
+
+    var nodes = scope.querySelectorAll(selector);
+    var results = [];
+    for (var i = 0; i < nodes.length; i++) {
+      results.push(window.HTMLWidgets.getInstance(nodes[i]));
+    }
+    return results;
+  };
+
+  var postRenderHandlers = [];
+  function invokePostRenderHandlers() {
+    while (postRenderHandlers.length) {
+      var handler = postRenderHandlers.shift();
+      if (handler) {
+        handler();
+      }
+    }
+  }
+
+  // Register the given callback function to be invoked after the
+  // next time static widgets are rendered.
+  window.HTMLWidgets.addPostRenderHandler = function(callback) {
+    postRenderHandlers.push(callback);
+  };
+
+  // Takes a new-style instance-bound definition, and returns an
+  // old-style class-bound definition. This saves us from having
+  // to rewrite all the logic in this file to accomodate both
+  // types of definitions.
+  function createLegacyDefinitionAdapter(defn) {
+    var result = {
+      name: defn.name,
+      type: defn.type,
+      initialize: function(el, width, height) {
+        return defn.factory(el, width, height);
+      },
+      renderValue: function(el, x, instance) {
+        return instance.renderValue(x);
+      },
+      resize: function(el, width, height, instance) {
+        return instance.resize(width, height);
+      }
+    };
+
+    if (defn.find)
+      result.find = defn.find;
+    if (defn.renderError)
+      result.renderError = defn.renderError;
+    if (defn.clearError)
+      result.clearError = defn.clearError;
+
+    return result;
+  }
+})();
+</script>
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div.vis-manipulation 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div.vis-manipulation div.vis-none:hover{box-shadow:1px 1px 8px transparent;cursor:default}div.vis-network div.vis-manipulation div.vis-none:active{box-shadow:1px 1px 8px transparent}div.vis-network div.vis-manipulation div.vis-none{line-height:23px;padding:0}div.vis-network div.vis-manipulation div.notification{font-weight:700;margin:2px}div.vis-network div.vis-manipulation 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div.vis-edit-mode button.vis-button.vis-edit,div.vis-network div.vis-manipulation button.vis-button.vis-edit{background-image:url("data:image/png;base64,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div.vis-edit-mode button.vis-button.vis-edit.vis-edit-mode{background-color:#fcfcfc;border:1px solid #ccc}div.vis-network div.vis-manipulation button.vis-button.vis-connect{background-image:url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAKT2lDQ1BQaG90b3Nob3AgSUNDIHByb2ZpbGUAAHjanVNnVFPpFj333vRCS4iAlEtvUhUIIFJCi4AUkSYqIQkQSoghodkVUcERRUUEG8igiAOOjoCMFVEsDIoK2AfkIaKOg6OIisr74Xuja9a89+bN/rXXPues852zzwfACAyWSDNRNYAMqUIeEeCDx8TG4eQuQIEKJHAAEAizZCFz/SMBAPh+PDwrIsAHvgABeNMLCADATZvAMByH/w/qQplcAYCEAcB0kThLCIAUAEB6jkKmAEBGAYCdmCZTAKAEAGDLY2LjAFAtAGAnf+bTAICd+Jl7AQBblCEVAaCRACATZYhEAGg7AKzPVopFAFgwABRmS8Q5ANgtADBJV2ZIALC3AMDOEAuyAAgMADBRiIUpAAR7AGDIIyN4AISZABRG8lc88SuuEOcqAAB4mbI8uSQ5RYFbCC1xB1dXLh4ozkkXKxQ2YQJhmkAuwnmZGTKBNA/g88wAAKCRFRHgg/P9eM4Ors7ONo62Dl8t6r8G/yJiYuP+5c+rcEAAAOF0ftH+LC+zGoA7BoBt/qIl7gRoXgugdfeLZrIPQLUAoOnaV/Nw+H48PEWhkLnZ2eXk5NhKxEJbYcpXff5nwl/AV/1s+X48/Pf14L7iJIEyXYFHBPjgwsz0TKUcz5IJhGLc5o9H/LcL//wd0yLESWK5WCoU41EScY5EmozzMqUiiUKSKcUl0v9k4t8s+wM+3zUAsGo+AXuRLahdYwP2SycQWHTA4vcAAPK7b8HUKAgDgGiD4c93/+8//UegJQCAZkmScQAAXkQkLlTKsz/HCAAARKCBKrBBG/TBGCzABhzBBdzBC/xgNoRCJMTCQhBCCmSAHHJgKayCQiiGzbAdKmAv1EAdNMBRaIaTcA4uwlW4Dj1wD/phCJ7BKLyBCQRByAgTYSHaiAFiilgjjggXmYX4IcFIBBKLJCDJiBRRIkuRNUgxUopUIFVIHfI9cgI5h1xGupE7yAAygvyGvEcxlIGyUT3UDLVDuag3GoRGogvQZHQxmo8WoJvQcrQaPYw2oefQq2gP2o8+Q8cwwOgYBzPEbDAuxsNCsTgsCZNjy7EirAyrxhqwVqwDu4n1Y8+xdwQSgUXACTYEd0IgYR5BSFhMWE7YSKggHCQ0EdoJNwkDhFHCJyKTqEu0JroR+cQYYjIxh1hILCPWEo8TLxB7iEPENyQSiUMyJ7mQAkmxpFTSEtJG0m5SI+ksqZs0SBojk8naZGuyBzmULCAryIXkneTD5DPkG+Qh8lsKnWJAcaT4U+IoUspqShnlEOU05QZlmDJBVaOaUt2ooVQRNY9aQq2htlKvUYeoEzR1mjnNgxZJS6WtopXTGmgXaPdpr+h0uhHdlR5Ol9BX0svpR+iX6AP0dwwNhhWDx4hnKBmbGAcYZxl3GK+YTKYZ04sZx1QwNzHrmOeZD5lvVVgqtip8FZHKCpVKlSaVGyovVKmqpqreqgtV81XLVI+pXlN9rkZVM1PjqQnUlqtVqp1Q61MbU2epO6iHqmeob1Q/pH5Z/YkGWcNMw09DpFGgsV/jvMYgC2MZs3gsIWsNq4Z1gTXEJrHN2Xx2KruY/R27iz2qqaE5QzNKM1ezUvOUZj8H45hx+Jx0TgnnKKeX836K3hTvKeIpG6Y0TLkxZVxrqpaXllirSKtRq0frvTau7aedpr1Fu1n7gQ5Bx0onXCdHZ4/OBZ3nU9lT3acKpxZNPTr1ri6qa6UbobtEd79up+6Ynr5egJ5Mb6feeb3n+hx9L/1U/W36p/VHDFgGswwkBtsMzhg8xTVxbzwdL8fb8VFDXcNAQ6VhlWGX4YSRudE8o9VGjUYPjGnGXOMk423GbcajJgYmISZLTepN7ppSTbmmKaY7TDtMx83MzaLN1pk1mz0x1zLnm+eb15vft2BaeFostqi2uGVJsuRaplnutrxuhVo5WaVYVVpds0atna0l1rutu6cRp7lOk06rntZnw7Dxtsm2qbcZsOXYBtuutm22fWFnYhdnt8Wuw+6TvZN9un2N/T0HDYfZDqsdWh1+c7RyFDpWOt6azpzuP33F9JbpL2dYzxDP2DPjthPLKcRpnVOb00dnF2e5c4PziIuJS4LLLpc+Lpsbxt3IveRKdPVxXeF60vWdm7Obwu2o26/uNu5p7ofcn8w0nymeWTNz0MPIQ+BR5dE/C5+VMGvfrH5PQ0+BZ7XnIy9jL5FXrdewt6V3qvdh7xc+9j5yn+M+4zw33jLeWV/MN8C3yLfLT8Nvnl+F30N/I/9k/3r/0QCngCUBZwOJgUGBWwL7+Hp8Ib+OPzrbZfay2e1BjKC5QRVBj4KtguXBrSFoyOyQrSH355jOkc5pDoVQfujW0Adh5mGLw34MJ4WHhVeGP45wiFga0TGXNXfR3ENz30T6RJZE3ptnMU85ry1KNSo+qi5qPNo3ujS6P8YuZlnM1VidWElsSxw5LiquNm5svt/87fOH4p3iC+N7F5gvyF1weaHOwvSFpxapLhIsOpZATIhOOJTwQRAqqBaMJfITdyWOCnnCHcJnIi/RNtGI2ENcKh5O8kgqTXqS7JG8NXkkxTOlLOW5hCepkLxMDUzdmzqeFpp2IG0yPTq9MYOSkZBxQqohTZO2Z+pn5mZ2y6xlhbL+xW6Lty8elQfJa7OQrAVZLQq2QqboVFoo1yoHsmdlV2a/zYnKOZarnivN7cyzytuQN5zvn//tEsIS4ZK2pYZLVy0dWOa9rGo5sjxxedsK4xUFK4ZWBqw8uIq2Km3VT6vtV5eufr0mek1rgV7ByoLBtQFr6wtVCuWFfevc1+1dT1gvWd+1YfqGnRs+FYmKrhTbF5cVf9go3HjlG4dvyr+Z3JS0qavEuWTPZtJm6ebeLZ5bDpaql+aXDm4N2dq0Dd9WtO319kXbL5fNKNu7g7ZDuaO/PLi8ZafJzs07P1SkVPRU+lQ27tLdtWHX+G7R7ht7vPY07NXbW7z3/T7JvttVAVVN1WbVZftJ+7P3P66Jqun4lvttXa1ObXHtxwPSA/0HIw6217nU1R3SPVRSj9Yr60cOxx++/p3vdy0NNg1VjZzG4iNwRHnk6fcJ3/ceDTradox7rOEH0x92HWcdL2pCmvKaRptTmvtbYlu6T8w+0dbq3nr8R9sfD5w0PFl5SvNUyWna6YLTk2fyz4ydlZ19fi753GDborZ752PO32oPb++6EHTh0kX/i+c7vDvOXPK4dPKy2+UTV7hXmq86X23qdOo8/pPTT8e7nLuarrlca7nuer21e2b36RueN87d9L158Rb/1tWeOT3dvfN6b/fF9/XfFt1+cif9zsu72Xcn7q28T7xf9EDtQdlD3YfVP1v+3Njv3H9qwHeg89HcR/cGhYPP/pH1jw9DBY+Zj8uGDYbrnjg+OTniP3L96fynQ89kzyaeF/6i/suuFxYvfvjV69fO0ZjRoZfyl5O/bXyl/erA6xmv28bCxh6+yXgzMV70VvvtwXfcdx3vo98PT+R8IH8o/2j5sfVT0Kf7kxmTk/8EA5jz/GMzLdsAAEEOaVRYdFhNTDpjb20uYWRvYmUueG1wAAAAAAA8P3hwYWNrZXQgYmVnaW49Iu+7vyIgaWQ9Ilc1TTBNcENlaGlIenJlU3pOVGN6a2M5ZCI/Pgo8eDp4bXBtZXRhIHhtbG5zOng9ImFkb2JlOm5zOm1ldGEvIiB4OnhtcHRrPSJBZG9iZSBYTVAgQ29yZSA1LjUtYzAyMSA3OS4xNTQ5MTEsIDIwMTMvMTAvMjktMTE6NDc6MTYgICAgICAgICI+CiAgIDxyZGY6UkRGIHhtbG5zOnJkZj0iaHR0cDovL3d3dy53My5vcmcvMTk5OS8wMi8yMi1yZGYtc3ludGF4LW5zIyI+CiAgICAgIDxyZGY6RGVzY3JpcHRpb24gcmRmOmFib3V0PSIiCiAgICAgICAgICAgIHhtbG5zOnhtcD0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wLyIKICAgICAgICAgICAgeG1sbnM6ZGM9Imh0dHA6Ly9wdXJsLm9yZy9kYy9lbGVtZW50cy8xLjEvIgogICAgICAgICAgICB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIKICAgICAgICAgICAgeG1sbnM6c3RFdnQ9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZUV2ZW50IyIKICAgICAgICAgICAgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiCiAgICAgICAgICAgIHhtbG5zOnBob3Rvc2hvcD0iaHR0cDovL25zLmFkb2JlLmNvbS9waG90b3Nob3AvMS4wLyIKICAgICAgICAgICAgeG1sbnM6dGlmZj0iaHR0cDovL25zLmFkb2JlLmNvbS90aWZmLzEuMC8iCiAgICAgICAgICAgIHhtbG5zOmV4aWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20vZXhpZi8xLjAvIj4KICAgICAgICAgPHhtcDpDcmVhdG9yVG9vbD5BZG9iZSBQaG90b3Nob3AgQ0MgKFdpbmRvd3MpPC94bXA6Q3JlYXRvclRvb2w+CiAgICAgICAgIDx4bXA6Q3JlYXRlRGF0ZT4yMDE0LTAxLTIyVDE5OjI0OjUxKzAxOjAwPC94bXA6Q3JlYXRlRGF0ZT4KICAgICAgICAgPHhtcDpNZXRhZGF0YURhdGU+MjAxNC0wMi0wNFQxNDozODo1NyswMTowMDwveG1wOk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div.vis-manipulation button.vis-button.vis-delete{background-image:url("data:image/png;base64,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+<script>/**
+ * vis-network
+ * https://visjs.github.io/vis-network/
+ *
+ * A dynamic, browser-based visualization library.
+ *
+ * @version 0.0.0-no-version
+ * @date    2021-09-28T12:03:00.413Z
+ *
+ * @copyright (c) 2011-2017 Almende B.V, http://almende.com
+ * @copyright (c) 2017-2019 visjs contributors, https://github.com/visjs
+ *
+ * @license
+ * vis.js is dual licensed under both
+ *
+ *   1. The Apache 2.0 License
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *   and
+ *
+ *   2. The MIT License
+ *      http://opensource.org/licenses/MIT
+ *
+ * vis.js may be distributed under either license.
+ */
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e?{background:t.background||e.background,border:t.border||e.border,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||e.highlight.background,border:t.highlight&&t.highlight.border||e.highlight.border},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||e.hover.border,background:t.hover&&t.hover.background||e.hover.background}}:{background:t.background||void 0,border:t.border||void 0,highlight:bh(t.highlight)?{border:t.highlight,background:t.highlight}:{background:t.highlight&&t.highlight.background||void 0,border:t.highlight&&t.highlight.border||void 0},hover:bh(t.hover)?{border:t.hover,background:t.hover}:{border:t.hover&&t.hover.border||void 0,background:t.hover&&t.hover.background||void 0}}}function Lh(t,e,i){t/=255,e/=255,i/=255;var n=Math.min(t,Math.min(e,i)),o=Math.max(t,Math.max(e,i));return 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gh.test(t)}function Kh(t){if(null===t||"object"!==go(t))return null;if(t instanceof Element)return t;var e=Gr(t);for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&"object"==go(t[i])&&(e[i]=Kh(t[i]));return e}function $h(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=function(t){return null!=t},r=function(t){return null!==t&&"object"===go(t)},s=function(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e))return!1;return!0};if(!r(t))throw new Error("Parameter mergeTarget must be an object");if(!r(e))throw new Error("Parameter options must be an object");if(!o(i))throw new Error("Parameter option must have a value");if(!r(n))throw new Error("Parameter globalOptions must be an object");var a=function(t,e,i){r(t[i])||(t[i]={});var n=e[i],o=t[i];for(var s in n)Object.prototype.hasOwnProperty.call(n,s)&&(o[s]=n[s])},h=e[i],l=r(n)&&!s(n),d=l?n[i]:void 0,c=d?d.enabled:void 0;if(void 0!==h){if("boolean"==typeof h)return r(t[i])||(t[i]={}),void(t[i].enabled=h);if(null===h&&!r(t[i])){if(!o(d))return;t[i]=Gr(d)}if(r(h)){var u=!0;void 0!==h.enabled?u=h.enabled:void 0!==c&&(u=d.enabled),a(t,e,i),t[i].enabled=u}}}var Zh={linear:function(t){return t},easeInQuad:function(t){return t*t},easeOutQuad:function(t){return t*(2-t)},easeInOutQuad:function(t){return t<.5?2*t*t:(4-2*t)*t-1},easeInCubic:function(t){return t*t*t},easeOutCubic:function(t){return--t*t*t+1},easeInOutCubic:function(t){return t<.5?4*t*t*t:(t-1)*(2*t-2)*(2*t-2)+1},easeInQuart:function(t){return t*t*t*t},easeOutQuart:function(t){return 1- --t*t*t*t},easeInOutQuart:function(t){return t<.5?8*t*t*t*t:1-8*--t*t*t*t},easeInQuint:function(t){return t*t*t*t*t},easeOutQuint:function(t){return 1+--t*t*t*t*t},easeInOutQuint:function(t){return t<.5?16*t*t*t*t*t:1+16*--t*t*t*t*t}};function Qh(t,e){var i;So(e)||(e=[e]);var n,o=Ja(t);try{for(o.s();!(n=o.n()).done;){var r=n.value;if(r){i=r[e[0]];for(var s=1;s<e.length;s++)i&&(i=i[e[s]]);if(void 0!==i)break}}}catch(t){o.e(t)}finally{o.f()}return i}var Jh={black:"#000000",navy:"#000080",darkblue:"#00008B",mediumblue:"#0000CD",blue:"#0000FF",darkgreen:"#006400",green:"#008000",teal:"#008080",darkcyan:"#008B8B",deepskyblue:"#00BFFF",darkturquoise:"#00CED1",mediumspringgreen:"#00FA9A",lime:"#00FF00",springgreen:"#00FF7F",aqua:"#00FFFF",cyan:"#00FFFF",midnightblue:"#191970",dodgerblue:"#1E90FF",lightseagreen:"#20B2AA",forestgreen:"#228B22",seagreen:"#2E8B57",darkslategray:"#2F4F4F",limegreen:"#32CD32",mediumseagreen:"#3CB371",turquoise:"#40E0D0",royalblue:"#4169E1",steelblue:"#4682B4",darkslateblue:"#483D8B",mediumturquoise:"#48D1CC",indigo:"#4B0082",darkolivegreen:"#556B2F",cadetblue:"#5F9EA0",cornflowerblue:"#6495ED",mediumaquamarine:"#66CDAA",dimgray:"#696969",slateblue:"#6A5ACD",olivedrab:"#6B8E23",slategray:"#708090",lightslategray:"#778899",mediumslateblue:"#7B68EE",lawngreen:"#7CFC00",chartreuse:"#7FFF00",aquamarine:"#7FFFD4",maroon:"#800000",purple:"#800080",olive:"#808000",gray:"#808080",skyblue:"#87CEEB",lightskyblue:"#87CEFA",blueviolet:"#8A2BE2",darkred:"#8B0000",darkmagenta:"#8B008B",saddlebrown:"#8B4513",darkseagreen:"#8FBC8F",lightgreen:"#90EE90",mediumpurple:"#9370D8",darkviolet:"#9400D3",palegreen:"#98FB98",darkorchid:"#9932CC",yellowgreen:"#9ACD32",sienna:"#A0522D",brown:"#A52A2A",darkgray:"#A9A9A9",lightblue:"#ADD8E6",greenyellow:"#ADFF2F",paleturquoise:"#AFEEEE",lightsteelblue:"#B0C4DE",powderblue:"#B0E0E6",firebrick:"#B22222",darkgoldenrod:"#B8860B",mediumorchid:"#BA55D3",rosybrown:"#BC8F8F",darkkhaki:"#BDB76B",silver:"#C0C0C0",mediumvioletred:"#C71585",indianred:"#CD5C5C",peru:"#CD853F",chocolate:"#D2691E",tan:"#D2B48C",lightgrey:"#D3D3D3",palevioletred:"#D87093",thistle:"#D8BFD8",orchid:"#DA70D6",goldenrod:"#DAA520",crimson:"#DC143C",gainsboro:"#DCDCDC",plum:"#DDA0DD",burlywood:"#DEB887",lightcyan:"#E0FFFF",lavender:"#E6E6FA",darksalmon:"#E9967A",violet:"#EE82EE",palegoldenrod:"#EEE8AA",lightcoral:"#F08080",khaki:"#F0E68C",aliceblue:"#F0F8FF",honeydew:"#F0FFF0",azure:"#F0FFFF",sandybrown:"#F4A460",wheat:"#F5DEB3",beige:"#F5F5DC",whitesmoke:"#F5F5F5",mintcream:"#F5FFFA",ghostwhite:"#F8F8FF",salmon:"#FA8072",antiquewhite:"#FAEBD7",linen:"#FAF0E6",lightgoldenrodyellow:"#FAFAD2",oldlace:"#FDF5E6",red:"#FF0000",fuchsia:"#FF00FF",magenta:"#FF00FF",deeppink:"#FF1493",orangered:"#FF4500",tomato:"#FF6347",hotpink:"#FF69B4",coral:"#FF7F50",darkorange:"#FF8C00",lightsalmon:"#FFA07A",orange:"#FFA500",lightpink:"#FFB6C1",pink:"#FFC0CB",gold:"#FFD700",peachpuff:"#FFDAB9",navajowhite:"#FFDEAD",moccasin:"#FFE4B5",bisque:"#FFE4C4",mistyrose:"#FFE4E1",blanchedalmond:"#FFEBCD",papayawhip:"#FFEFD5",lavenderblush:"#FFF0F5",seashell:"#FFF5EE",cornsilk:"#FFF8DC",lemonchiffon:"#FFFACD",floralwhite:"#FFFAF0",snow:"#FFFAFA",yellow:"#FFFF00",lightyellow:"#FFFFE0",ivory:"#FFFFF0",white:"#FFFFFF"},tl=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;Nn(this,t),this.pixelRatio=e,this.generated=!1,this.centerCoordinates={x:144.5,y:144.5},this.r=289*.49,this.color={r:255,g:255,b:255,a:1},this.hueCircle=void 0,this.initialColor={r:255,g:255,b:255,a:1},this.previousColor=void 0,this.applied=!1,this.updateCallback=function(){},this.closeCallback=function(){},this._create()}return Fn(t,[{key:"insertTo",value:function(t){void 0!==this.hammer&&(this.hammer.destroy(),this.hammer=void 0),this.container=t,this.container.appendChild(this.frame),this._bindHammer(),this._setSize()}},{key:"setUpdateCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker update callback is not a function.");this.updateCallback=t}},{key:"setCloseCallback",value:function(t){if("function"!=typeof t)throw new Error("Function attempted to set as colorPicker closing callback is not a function.");this.closeCallback=t}},{key:"_isColorString",value:function(t){if("string"==typeof t)return Jh[t]}},{key:"setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if("none"!==t){var i,n=this._isColorString(t);if(void 0!==n&&(t=n),!0===bh(t)){if(!0===Xh(t)){var o=t.substr(4).substr(0,t.length-5).split(",");i={r:o[0],g:o[1],b:o[2],a:1}}else if(!0===Gh(t)){var r=t.substr(5).substr(0,t.length-6).split(",");i={r:r[0],g:r[1],b:r[2],a:r[3]}}else if(!0===Yh(t)){var s=Ah(t);i={r:s.r,g:s.g,b:s.b,a:1}}}else if(t instanceof Object&&void 0!==t.r&&void 0!==t.g&&void 0!==t.b){var a=void 0!==t.a?t.a:"1.0";i={r:t.r,g:t.g,b:t.b,a:a}}if(void 0===i)throw new Error("Unknown color passed to the colorPicker. Supported are strings: rgb, hex, rgba. Object: rgb ({r:r,g:g,b:b,[a:a]}). Supplied: "+es(t));this._setColor(i,e)}}},{key:"show",value:function(){void 0!==this.closeCallback&&(this.closeCallback(),this.closeCallback=void 0),this.applied=!1,this.frame.style.display="block",this._generateHueCircle()}},{key:"_hide",value:function(){var t=this,e=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];!0===e&&(this.previousColor=At({},this.color)),!0===this.applied&&this.updateCallback(this.initialColor),this.frame.style.display="none",rs((function(){void 0!==t.closeCallback&&(t.closeCallback(),t.closeCallback=void 0)}),0)}},{key:"_save",value:function(){this.updateCallback(this.color),this.applied=!1,this._hide()}},{key:"_apply",value:function(){this.applied=!0,this.updateCallback(this.color),this._updatePicker(this.color)}},{key:"_loadLast",value:function(){void 0!==this.previousColor?this.setColor(this.previousColor,!1):alert("There is no last color to load...")}},{key:"_setColor",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];!0===e&&(this.initialColor=At({},t)),this.color=t;var i=Lh(t.r,t.g,t.b),n=2*Math.PI,o=this.r*i.s,r=this.centerCoordinates.x+o*Math.sin(n*i.h),s=this.centerCoordinates.y+o*Math.cos(n*i.h);this.colorPickerSelector.style.left=r-.5*this.colorPickerSelector.clientWidth+"px",this.colorPickerSelector.style.top=s-.5*this.colorPickerSelector.clientHeight+"px",this._updatePicker(t)}},{key:"_setOpacity",value:function(t){this.color.a=t/100,this._updatePicker(this.color)}},{key:"_setBrightness",value:function(t){var e=Lh(this.color.r,this.color.g,this.color.b);e.v=t/100;var i=qh(e.h,e.s,e.v);i.a=this.color.a,this.color=i,this._updatePicker()}},{key:"_updatePicker",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.color,e=Lh(t.r,t.g,t.b),i=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(i.webkitBackingStorePixelRatio||i.mozBackingStorePixelRatio||i.msBackingStorePixelRatio||i.oBackingStorePixelRatio||i.backingStorePixelRatio||1)),i.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var n=this.colorPickerCanvas.clientWidth,o=this.colorPickerCanvas.clientHeight;i.clearRect(0,0,n,o),i.putImageData(this.hueCircle,0,0),i.fillStyle="rgba(0,0,0,"+(1-e.v)+")",hs(i).call(i),this.brightnessRange.value=100*e.v,this.opacityRange.value=100*t.a,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}},{key:"_setSize",value:function(){this.colorPickerCanvas.style.width="100%",this.colorPickerCanvas.style.height="100%",this.colorPickerCanvas.width=289*this.pixelRatio,this.colorPickerCanvas.height=289*this.pixelRatio}},{key:"_create",value:function(){var t,e,i,n;if(this.frame=document.createElement("div"),this.frame.className="vis-color-picker",this.colorPickerDiv=document.createElement("div"),this.colorPickerSelector=document.createElement("div"),this.colorPickerSelector.className="vis-selector",this.colorPickerDiv.appendChild(this.colorPickerSelector),this.colorPickerCanvas=document.createElement("canvas"),this.colorPickerDiv.appendChild(this.colorPickerCanvas),this.colorPickerCanvas.getContext){var o=this.colorPickerCanvas.getContext("2d");this.pixelRatio=(window.devicePixelRatio||1)/(o.webkitBackingStorePixelRatio||o.mozBackingStorePixelRatio||o.msBackingStorePixelRatio||o.oBackingStorePixelRatio||o.backingStorePixelRatio||1),this.colorPickerCanvas.getContext("2d").setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}else{var r=document.createElement("DIV");r.style.color="red",r.style.fontWeight="bold",r.style.padding="10px",r.innerText="Error: your browser does not support HTML canvas",this.colorPickerCanvas.appendChild(r)}this.colorPickerDiv.className="vis-color",this.opacityDiv=document.createElement("div"),this.opacityDiv.className="vis-opacity",this.brightnessDiv=document.createElement("div"),this.brightnessDiv.className="vis-brightness",this.arrowDiv=document.createElement("div"),this.arrowDiv.className="vis-arrow",this.opacityRange=document.createElement("input");try{this.opacityRange.type="range",this.opacityRange.min="0",this.opacityRange.max="100"}catch(t){}this.opacityRange.value="100",this.opacityRange.className="vis-range",this.brightnessRange=document.createElement("input");try{this.brightnessRange.type="range",this.brightnessRange.min="0",this.brightnessRange.max="100"}catch(t){}this.brightnessRange.value="100",this.brightnessRange.className="vis-range",this.opacityDiv.appendChild(this.opacityRange),this.brightnessDiv.appendChild(this.brightnessRange);var s=this;this.opacityRange.onchange=function(){s._setOpacity(this.value)},this.opacityRange.oninput=function(){s._setOpacity(this.value)},this.brightnessRange.onchange=function(){s._setBrightness(this.value)},this.brightnessRange.oninput=function(){s._setBrightness(this.value)},this.brightnessLabel=document.createElement("div"),this.brightnessLabel.className="vis-label vis-brightness",this.brightnessLabel.innerText="brightness:",this.opacityLabel=document.createElement("div"),this.opacityLabel.className="vis-label vis-opacity",this.opacityLabel.innerText="opacity:",this.newColorDiv=document.createElement("div"),this.newColorDiv.className="vis-new-color",this.newColorDiv.innerText="new",this.initialColorDiv=document.createElement("div"),this.initialColorDiv.className="vis-initial-color",this.initialColorDiv.innerText="initial",this.cancelButton=document.createElement("div"),this.cancelButton.className="vis-button vis-cancel",this.cancelButton.innerText="cancel",this.cancelButton.onclick=Vt(t=this._hide).call(t,this,!1),this.applyButton=document.createElement("div"),this.applyButton.className="vis-button vis-apply",this.applyButton.innerText="apply",this.applyButton.onclick=Vt(e=this._apply).call(e,this),this.saveButton=document.createElement("div"),this.saveButton.className="vis-button vis-save",this.saveButton.innerText="save",this.saveButton.onclick=Vt(i=this._save).call(i,this),this.loadButton=document.createElement("div"),this.loadButton.className="vis-button vis-load",this.loadButton.innerText="load last",this.loadButton.onclick=Vt(n=this._loadLast).call(n,this),this.frame.appendChild(this.colorPickerDiv),this.frame.appendChild(this.arrowDiv),this.frame.appendChild(this.brightnessLabel),this.frame.appendChild(this.brightnessDiv),this.frame.appendChild(this.opacityLabel),this.frame.appendChild(this.opacityDiv),this.frame.appendChild(this.newColorDiv),this.frame.appendChild(this.initialColorDiv),this.frame.appendChild(this.cancelButton),this.frame.appendChild(this.applyButton),this.frame.appendChild(this.saveButton),this.frame.appendChild(this.loadButton)}},{key:"_bindHammer",value:function(){var t=this;this.drag={},this.pinch={},this.hammer=new dh(this.colorPickerCanvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.on("hammer.input",(function(e){e.isFirst&&t._moveSelector(e)})),this.hammer.on("tap",(function(e){t._moveSelector(e)})),this.hammer.on("panstart",(function(e){t._moveSelector(e)})),this.hammer.on("panmove",(function(e){t._moveSelector(e)})),this.hammer.on("panend",(function(e){t._moveSelector(e)}))}},{key:"_generateHueCircle",value:function(){if(!1===this.generated){var t=this.colorPickerCanvas.getContext("2d");void 0===this.pixelRation&&(this.pixelRatio=(window.devicePixelRatio||1)/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)),t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0);var e,i,n,o,r=this.colorPickerCanvas.clientWidth,s=this.colorPickerCanvas.clientHeight;t.clearRect(0,0,r,s),this.centerCoordinates={x:.5*r,y:.5*s},this.r=.49*r;var a,h=2*Math.PI/360,l=1/this.r;for(n=0;n<360;n++)for(o=0;o<this.r;o++)e=this.centerCoordinates.x+o*Math.sin(h*n),i=this.centerCoordinates.y+o*Math.cos(h*n),a=qh(.002777777777777778*n,o*l,1),t.fillStyle="rgb("+a.r+","+a.g+","+a.b+")",t.fillRect(e-.5,i-.5,2,2);t.strokeStyle="rgba(0,0,0,1)",t.stroke(),this.hueCircle=t.getImageData(0,0,r,s)}this.generated=!0}},{key:"_moveSelector",value:function(t){var e=this.colorPickerDiv.getBoundingClientRect(),i=t.center.x-e.left,n=t.center.y-e.top,o=.5*this.colorPickerDiv.clientHeight,r=.5*this.colorPickerDiv.clientWidth,s=i-r,a=n-o,h=Math.atan2(s,a),l=.98*Math.min(Math.sqrt(s*s+a*a),r),d=Math.cos(h)*l+o,c=Math.sin(h)*l+r;this.colorPickerSelector.style.top=d-.5*this.colorPickerSelector.clientHeight+"px",this.colorPickerSelector.style.left=c-.5*this.colorPickerSelector.clientWidth+"px";var u=h/(2*Math.PI);u=u<0?u+1:u;var f=l/this.r,p=Lh(this.color.r,this.color.g,this.color.b);p.h=u,p.s=f;var v=qh(p.h,p.s,p.v);v.a=this.color.a,this.color=v,this.initialColorDiv.style.backgroundColor="rgba("+this.initialColor.r+","+this.initialColor.g+","+this.initialColor.b+","+this.initialColor.a+")",this.newColorDiv.style.backgroundColor="rgba("+this.color.r+","+this.color.g+","+this.color.b+","+this.color.a+")"}}]),t}();function el(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];if(e.length<1)throw new TypeError("Invalid arguments.");if(1===e.length)return document.createTextNode(e[0]);var n=document.createElement(e[0]);return n.appendChild(el.apply(void 0,wo(Oo(e).call(e,1)))),n}var il,nl=function(){function t(e,i,n){var o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:1,r=arguments.length>4&&void 0!==arguments[4]?arguments[4]:function(){return!1};Nn(this,t),this.parent=e,this.changedOptions=[],this.container=i,this.allowCreation=!1,this.hideOption=r,this.options={},this.initialized=!1,this.popupCounter=0,this.defaultOptions={enabled:!1,filter:!0,container:void 0,showButton:!0},At(this.options,this.defaultOptions),this.configureOptions=n,this.moduleOptions={},this.domElements=[],this.popupDiv={},this.popupLimit=5,this.popupHistory={},this.colorPicker=new tl(o),this.wrapper=void 0}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){this.popupHistory={},this._removePopup();var e=!0;if("string"==typeof t)this.options.filter=t;else if(So(t))this.options.filter=t.join();else if("object"===go(t)){if(null==t)throw new TypeError("options cannot be null");void 0!==t.container&&(this.options.container=t.container),void 0!==mr(t)&&(this.options.filter=mr(t)),void 0!==t.showButton&&(this.options.showButton=t.showButton),void 0!==t.enabled&&(e=t.enabled)}else"boolean"==typeof t?(this.options.filter=!0,e=t):"function"==typeof t&&(this.options.filter=t,e=!0);!1===mr(this.options)&&(e=!1),this.options.enabled=e}this._clean()}},{key:"setModuleOptions",value:function(t){this.moduleOptions=t,!0===this.options.enabled&&(this._clean(),void 0!==this.options.container&&(this.container=this.options.container),this._create())}},{key:"_create",value:function(){this._clean(),this.changedOptions=[];var t=mr(this.options),e=0,i=!1;for(var n in this.configureOptions)Object.prototype.hasOwnProperty.call(this.configureOptions,n)&&(this.allowCreation=!1,i=!1,"function"==typeof t?i=(i=t(n,[]))||this._handleObject(this.configureOptions[n],[n],!0):!0!==t&&-1===Hr(t).call(t,n)||(i=!0),!1!==i&&(this.allowCreation=!0,e>0&&this._makeItem([]),this._makeHeader(n),this._handleObject(this.configureOptions[n],[n])),e++);this._makeButton(),this._push()}},{key:"_push",value:function(){this.wrapper=document.createElement("div"),this.wrapper.className="vis-configuration-wrapper",this.container.appendChild(this.wrapper);for(var t=0;t<this.domElements.length;t++)this.wrapper.appendChild(this.domElements[t]);this._showPopupIfNeeded()}},{key:"_clean",value:function(){for(var t=0;t<this.domElements.length;t++)this.wrapper.removeChild(this.domElements[t]);void 0!==this.wrapper&&(this.container.removeChild(this.wrapper),this.wrapper=void 0),this.domElements=[],this._removePopup()}},{key:"_getValue",value:function(t){for(var e=this.moduleOptions,i=0;i<t.length;i++){if(void 0===e[t[i]]){e=void 0;break}e=e[t[i]]}return e}},{key:"_makeItem",value:function(t){if(!0===this.allowCreation){var e=document.createElement("div");e.className="vis-configuration vis-config-item vis-config-s"+t.length;for(var i=arguments.length,n=new Array(i>1?i-1:0),o=1;o<i;o++)n[o-1]=arguments[o];return Wo(n).call(n,(function(t){e.appendChild(t)})),this.domElements.push(e),this.domElements.length}return 0}},{key:"_makeHeader",value:function(t){var e=document.createElement("div");e.className="vis-configuration vis-config-header",e.innerText=t,this._makeItem([],e)}},{key:"_makeLabel",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");if(n.className="vis-configuration vis-config-label vis-config-s"+e.length,!0===i){for(;n.firstChild;)n.removeChild(n.firstChild);n.appendChild(el("i","b",t))}else n.innerText=t+":";return n}},{key:"_makeDropdown",value:function(t,e,i){var n=document.createElement("select");n.className="vis-configuration vis-config-select";var o=0;void 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e=this.domElements[this.popupDiv.index].getBoundingClientRect();this.popupDiv.html.style.left=e.left+"px",this.popupDiv.html.style.top=e.top-30+"px",document.body.appendChild(this.popupDiv.html),this.popupDiv.hideTimeout=rs((function(){t.popupDiv.html.style.opacity=0}),1500),this.popupDiv.deleteTimeout=rs((function(){t._removePopup()}),1800)}}},{key:"_makeCheckbox",value:function(t,e,i){var n=document.createElement("input");n.type="checkbox",n.className="vis-configuration vis-config-checkbox",n.checked=t,void 0!==e&&(n.checked=e,e!==t&&("object"===go(t)?e!==t.enabled&&this.changedOptions.push({path:i,value:e}):this.changedOptions.push({path:i,value:e})));var o=this;n.onchange=function(){o._update(this.checked,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeTextInput",value:function(t,e,i){var n=document.createElement("input");n.type="text",n.className="vis-configuration vis-config-text",n.value=e,e!==t&&this.changedOptions.push({path:i,value:e});var o=this;n.onchange=function(){o._update(this.value,i)};var r=this._makeLabel(i[i.length-1],i);this._makeItem(i,r,n)}},{key:"_makeColorField",value:function(t,e,i){var n=this,o=t[1],r=document.createElement("div");"none"!==(e=void 0===e?o:e)?(r.className="vis-configuration vis-config-colorBlock",r.style.backgroundColor=e):r.className="vis-configuration vis-config-colorBlock none",e=void 0===e?o:e,r.onclick=function(){n._showColorPicker(e,r,i)};var s=this._makeLabel(i[i.length-1],i);this._makeItem(i,s,r)}},{key:"_showColorPicker",value:function(t,e,i){var n=this;e.onclick=function(){},this.colorPicker.insertTo(e),this.colorPicker.show(),this.colorPicker.setColor(t),this.colorPicker.setUpdateCallback((function(t){var o="rgba("+t.r+","+t.g+","+t.b+","+t.a+")";e.style.backgroundColor=o,n._update(o,i)})),this.colorPicker.setCloseCallback((function(){e.onclick=function(){n._showColorPicker(t,e,i)}}))}},{key:"_handleObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=!1,o=mr(this.options),r=!1;for(var s in t)if(Object.prototype.hasOwnProperty.call(t,s)){n=!0;var a=t[s],h=Sh(e,s);if("function"==typeof o&&!1===(n=o(s,e))&&!So(a)&&"string"!=typeof a&&"boolean"!=typeof a&&a instanceof Object&&(this.allowCreation=!1,n=this._handleObject(a,h,!0),this.allowCreation=!1===i),!1!==n){r=!0;var l=this._getValue(h);if(So(a))this._handleArray(a,l,h);else if("string"==typeof a)this._makeTextInput(a,l,h);else if("boolean"==typeof a)this._makeCheckbox(a,l,h);else if(a instanceof Object){if(!this.hideOption(e,s,this.moduleOptions))if(void 0!==a.enabled){var d=Sh(h,"enabled"),c=this._getValue(d);if(!0===c){var u=this._makeLabel(s,h,!0);this._makeItem(h,u),r=this._handleObject(a,h)||r}else this._makeCheckbox(a,c,h)}else{var f=this._makeLabel(s,h,!0);this._makeItem(h,f),r=this._handleObject(a,h)||r}}else console.error("dont know how to handle",a,s,h)}}return r}},{key:"_handleArray",value:function(t,e,i){"string"==typeof t[0]&&"color"===t[0]?(this._makeColorField(t,e,i),t[1]!==e&&this.changedOptions.push({path:i,value:e})):"string"==typeof t[0]?(this._makeDropdown(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:e})):"number"==typeof t[0]&&(this._makeRange(t,e,i),t[0]!==e&&this.changedOptions.push({path:i,value:Number(e)}))}},{key:"_update",value:function(t,e){var i=this._constructOptions(t,e);this.parent.body&&this.parent.body.emitter&&this.parent.body.emitter.emit&&this.parent.body.emitter.emit("configChange",i),this.initialized=!0,this.parent.setOptions(i)}},{key:"_constructOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},n=i;t="false"!==(t="true"===t||t)&&t;for(var o=0;o<e.length;o++)"global"!==e[o]&&(void 0===n[e[o]]&&(n[e[o]]={}),o!==e.length-1?n=n[e[o]]:n[e[o]]=t);return i}},{key:"_printOptions",value:function(){for(var 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null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),"Directed"===t.type&&(e.arrows="to"),t.color&&!1===n.edges.inheritColor&&(e.color=t.color),e}));return{nodes:Io(i=t.nodes).call(i,(function(t){var e={id:t.id,fixed:n.nodes.fixed&&null!=t.x&&null!=t.y};return null!=t.attributes&&(e.attributes=t.attributes),null!=t.label&&(e.label=t.label),null!=t.size&&(e.size=t.size),null!=t.attributes&&null!=t.attributes.title&&(e.title=t.attributes.title),null!=t.title&&(e.title=t.title),null!=t.x&&(e.x=t.x),null!=t.y&&(e.y=t.y),null!=t.color&&(!0===n.nodes.parseColor?e.color=t.color:e.color={background:t.color,border:t.color,highlight:{background:t.color,border:t.color},hover:{background:t.color,border:t.color}}),e})),edges:r}}var Gl=Object.freeze({__proto__:null,parseGephi:Xl}),Kl=Object.freeze({__proto__:null,en:{addDescription:"Click in an empty space to place a new node.",addEdge:"Add 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null;for(var n=i.value[1],o=t(i.value[1],i.value[0]);!(i=e.next()).done;){var r=uo(i.value,2),s=r[0],a=r[1],h=t(a,s);h<o&&(o=h,n=a)}return n}},{key:"reduce",value:function(t,e){var i,n=Yc(this._pairs);try{for(n.s();!(i=n.n()).done;){var o=uo(i.value,2),r=o[0];e=t(e,o[1],r)}}catch(t){n.e(t)}finally{n.f()}return e}},{key:"sort",value:function(t){var i=this;return new e(jn({},ic,(function(){var e;return nc(xc(e=wo(i._pairs)).call(e,(function(e,i){var n=uo(e,2),o=n[0],r=n[1],s=uo(i,2),a=s[0],h=s[1];return t(r,h,o,a)})))})))}}]),e}(ic);var tu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o;return Nn(this,i),(o=e.call(this))._queue=null,t&&!So(t)&&(n=t,t=[]),o._options=n||{},o._data=new vd,o.length=0,o._idProp=o._options.fieldId||"id",t&&t.length&&o.add(t),o.setOptions(n),o}return Fn(i,[{key:"idProp",get:function(){return this._idProp}},{key:"setOptions",value:function(t){t&&void 0!==t.queue&&(!1===t.queue?this._queue&&(this._queue.destroy(),this._queue=null):(this._queue||(this._queue=Zc.extend(this,{replace:["add","update","remove"]})),t.queue&&"object"===go(t.queue)&&this._queue.setOptions(t.queue)))}},{key:"add",value:function(t,e){var i,n=this,o=[];if(So(t)){var r=Io(t).call(t,(function(t){return t[n._idProp]}));if(Od(r).call(r,(function(t){return n._data.has(t)})))throw new Error("A duplicate id was found in the parameter array.");for(var s=0,a=t.length;s<a;s++)i=this._addItem(t[s]),o.push(i)}else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");i=this._addItem(t),o.push(i)}return o.length&&this._trigger("add",{items:o},e),o}},{key:"update",value:function(t,e){var i=this,n=[],o=[],r=[],s=[],a=this._idProp,h=function(t){var e=t[a];if(null!=e&&i._data.has(e)){var h=t,l=At({},i._data.get(e)),d=i._updateItem(h);o.push(d),s.push(h),r.push(l)}else{var c=i._addItem(t);n.push(c)}};if(So(t))for(var l=0,d=t.length;l<d;l++)t[l]&&"object"===go(t[l])?h(t[l]):console.warn("Ignoring input item, which is not an object at index "+l);else{if(!t||"object"!==go(t))throw new Error("Unknown dataType");h(t)}if(n.length&&this._trigger("add",{items:n},e),o.length){var c={items:o,oldData:r,data:s};this._trigger("update",c,e)}return Eo(n).call(n,o)}},{key:"updateOnly",value:function(t,e){var i,n=this;So(t)||(t=[t]);var o=Io(i=Io(t).call(t,(function(t){var e=n._data.get(t[n._idProp]);if(null==e)throw new Error("Updating non-existent items is not allowed.");return{oldData:e,update:t}}))).call(i,(function(t){var e=t.oldData,i=t.update,o=e[n._idProp],r=ih(e,i);return n._data.set(o,r),{id:o,oldData:e,updatedData:r}}));if(o.length){var r={items:Io(o).call(o,(function(t){return t.id})),oldData:Io(o).call(o,(function(t){return t.oldData})),data:Io(o).call(o,(function(t){return t.updatedData}))};return this._trigger("update",r,e),r.items}return[]}},{key:"get",value:function(t,e){var i=void 0,n=void 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i;return t?Kd(i=So(e)?e:zo(e)).call(i,(function(e,i){return e[i]=t[i],e}),{}):t}},{key:"_sort",value:function(t,e){if("string"==typeof e){var i=e;xc(t).call(t,(function(t,e){var n=t[i],o=e[i];return n>o?1:n<o?-1:0}))}else{if("function"!=typeof e)throw new TypeError("Order must be a function or a string");xc(t).call(t,e)}}},{key:"remove",value:function(t,e){for(var i=[],n=[],o=So(t)?t:[t],r=0,s=o.length;r<s;r++){var a=this._remove(o[r]);if(a){var h=a[this._idProp];null!=h&&(i.push(h),n.push(a))}}return i.length&&this._trigger("remove",{items:i,oldData:n},e),i}},{key:"_remove",value:function(t){var e;if($c(t)?e=t:t&&"object"===go(t)&&(e=t[this._idProp]),null!=e&&this._data.has(e)){var i=this._data.get(e)||null;return this._data.delete(e),--this.length,i}return null}},{key:"clear",value:function(t){for(var e,i=wo(Sc(e=this._data).call(e)),n=[],o=0,r=i.length;o<r;o++)n.push(this._data.get(i[o]));return 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this._data.set(i,e),++this.length,i}},{key:"_updateItem",value:function(t){var e=t[this._idProp];if(null==e)throw new Error("Cannot update item: item has no id (item: "+es(t)+")");var i=this._data.get(e);if(!i)throw new Error("Cannot update item: no item with id "+e+" found");return this._data.set(e,Vc(Vc({},i),t)),e}},{key:"stream",value:function(t){if(t){var e=this._data;return new Jc(jn({},ic,Hd.mark((function i(){var n,o,r,s;return Hd.wrap((function(i){for(;;)switch(i.prev=i.next){case 0:n=Yc(t),i.prev=1,n.s();case 3:if((o=n.n()).done){i.next=11;break}if(r=o.value,null==(s=e.get(r))){i.next=9;break}return i.next=9,[r,s];case 9:i.next=3;break;case 11:i.next=16;break;case 13:i.prev=13,i.t0=i.catch(1),n.e(i.t0);case 16:return i.prev=16,n.f(),i.finish(16);case 19:case"end":return i.stop()}}),i,null,[[1,13,16,19]])}))))}var i;return new Jc(jn({},ic,Vt(i=Nc(this._data)).call(i,this._data)))}}]),i}(Qc),eu=function(t){Ad(i,t);var e=Uc(i);function i(t,n){var o,r;return 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e.setOptions&&"function"==typeof e.stream&&"function"==typeof e.update&&"function"==typeof e.updateOnly}function nu(t,e){return"object"===go(e)&&null!==e&&t===e.idProp&&"function"==typeof Wo(e)&&"function"==typeof e.get&&"function"==typeof e.getDataSet&&"function"==typeof e.getIds&&"number"==typeof e.length&&"function"==typeof Io(e)&&"function"==typeof e.off&&"function"==typeof e.on&&"function"==typeof e.stream&&iu(t,e.getDataSet())}var ou=Object.freeze({__proto__:null,DELETE:eh,DataSet:tu,DataStream:Jc,DataView:eu,Queue:Zc,createNewDataPipeFrom:function(t){return new Kc(t)},isDataSetLike:iu,isDataViewLike:nu}),ru=Tr.trim,su=a.parseFloat,au=1/su(xr+"-0")!=-1/0?function(t){var e=ru(Qt(t)),i=su(e);return 0===i&&"-"==e.charAt(0)?-0:i}:su;gt({global:!0,forced:parseFloat!=au},{parseFloat:au});var hu=k.parseFloat,lu=Li.f,du=h((function(){return!Object.getOwnPropertyNames(1)}));gt({target:"Object",stat:!0,forced:du},{getOwnPropertyNames:lu});var cu=k.Object,uu=function(t){return cu.getOwnPropertyNames(t)};function fu(t,e){var i=["node","edge","label"],n=!0,o=Qh(e,"chosen");if("boolean"==typeof o)n=o;else if("object"===go(o)){if(-1===Hr(i).call(i,t))throw new Error("choosify: subOption '"+t+"' should be one of '"+i.join("', '")+"'");var r=Qh(e,["chosen",t]);"boolean"!=typeof r&&"function"!=typeof r||(n=r)}return n}function pu(t,e,i){if(t.width<=0||t.height<=0)return!1;if(void 0!==i){var n={x:e.x-i.x,y:e.y-i.y};if(0!==i.angle){var o=-i.angle;e={x:Math.cos(o)*n.x-Math.sin(o)*n.y,y:Math.sin(o)*n.x+Math.cos(o)*n.y}}else e=n}var r=t.x+t.width,s=t.y+t.width;return t.left<e.x&&r>e.x&&t.top<e.y&&s>e.y}function vu(t){return"string"==typeof t&&""!==t}function gu(t,e,i,n){var o=n.x,r=n.y;if("function"==typeof n.distanceToBorder){var s=n.distanceToBorder(t,e),a=Math.sin(e)*s,h=Math.cos(e)*s;h===s?(o+=s,r=n.y):a===s?(o=n.x,r-=s):(o+=h,r-=a)}else n.shape.width>n.shape.height?(o=n.x+.5*n.shape.width,r=n.y-i):(o=n.x+i,r=n.y-.5*n.shape.height);return{x:o,y:r}}var yu=function(){function t(e){Nn(this,t),this.measureText=e,this.current=0,this.width=0,this.height=0,this.lines=[]}return Fn(t,[{key:"_add",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:"normal";void 0===this.lines[t]&&(this.lines[t]={width:0,height:0,blocks:[]});var n=e;void 0!==e&&""!==e||(n=" ");var o=this.measureText(n,i),r=At({},Dc(o));r.text=e,r.width=o.width,r.mod=i,void 0!==e&&""!==e||(r.width=0),this.lines[t].blocks.push(r),this.lines[t].width+=r.width}},{key:"curWidth",value:function(){var t=this.lines[this.current];return void 0===t?0:t.width}},{key:"append",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e)}},{key:"newLine",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal";this._add(this.current,t,e),this.current++}},{key:"determineLineHeights",value:function(){for(var t=0;t<this.lines.length;t++){var e=this.lines[t],i=0;if(void 0!==e.blocks)for(var n=0;n<e.blocks.length;n++){var o=e.blocks[n];i<o.height&&(i=o.height)}e.height=i}}},{key:"determineLabelSize",value:function(){for(var t=0,e=0,i=0;i<this.lines.length;i++){var n=this.lines[i];n.width>t&&(t=n.width),e+=n.height}this.width=t,this.height=e}},{key:"removeEmptyBlocks",value:function(){for(var t=[],e=0;e<this.lines.length;e++){var i=this.lines[e];if(0!==i.blocks.length&&(e!==this.lines.length-1||0!==i.width)){var n={};At(n,i),n.blocks=[];for(var o=void 0,r=[],s=0;s<i.blocks.length;s++){var a=i.blocks[s];0!==a.width?r.push(a):void 0===o&&(o=a)}0===r.length&&void 0!==o&&r.push(o),n.blocks=r,t.push(n)}}return t}},{key:"finalize",value:function(){this.determineLineHeights(),this.determineLabelSize();var t=this.removeEmptyBlocks();return{width:this.width,height:this.height,lines:t}}}]),t}(),mu={"<b>":/<b>/,"<i>":/<i>/,"<code>":/<code>/,"</b>":/<\/b>/,"</i>":/<\/i>/,"</code>":/<\/code>/,"*":/\*/,_:/_/,"`":/`/,afterBold:/[^*]/,afterItal:/[^_]/,afterMono:/[^`]/},bu=function(){function t(e){Nn(this,t),this.text=e,this.bold=!1,this.ital=!1,this.mono=!1,this.spacing=!1,this.position=0,this.buffer="",this.modStack=[],this.blocks=[]}return Fn(t,[{key:"mod",value:function(){return 0===this.modStack.length?"normal":this.modStack[0]}},{key:"modName",value:function(){return 0===this.modStack.length?"normal":"mono"===this.modStack[0]?"mono":this.bold&&this.ital?"boldital":this.bold?"bold":this.ital?"ital":void 0}},{key:"emitBlock",value:function(){this.spacing&&(this.add(" "),this.spacing=!1),this.buffer.length>0&&(this.blocks.push({text:this.buffer,mod:this.modName()}),this.buffer="")}},{key:"add",value:function(t){" "===t&&(this.spacing=!0),this.spacing&&(this.buffer+=" ",this.spacing=!1)," "!=t&&(this.buffer+=t)}},{key:"parseWS",value:function(t){return!!/[ \t]/.test(t)&&(this.mono?this.add(t):this.spacing=!0,!0)}},{key:"setTag",value:function(t){this.emitBlock(),this[t]=!0,this.modStack.unshift(t)}},{key:"unsetTag",value:function(t){this.emitBlock(),this[t]=!1,this.modStack.shift()}},{key:"parseStartTag",value:function(t,e){return!(this.mono||this[t]||!this.match(e))&&(this.setTag(t),!0)}},{key:"match",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.prepareRegExp(t),n=uo(i,2),o=n[0],r=n[1],s=o.test(this.text.substr(this.position,r));return s&&e&&(this.position+=r-1),s}},{key:"parseEndTag",value:function(t,e,i){var n=this.mod()===t;return!(!(n="mono"===t?n&&this.mono:n&&!this.mono)||!this.match(e))&&(void 0!==i?(this.position===this.text.length-1||this.match(i,!1))&&this.unsetTag(t):this.unsetTag(t),!0)}},{key:"replace",value:function(t,e){return!!this.match(t)&&(this.add(e),this.position+=length-1,!0)}},{key:"prepareRegExp",value:function(t){var e,i;if(t instanceof RegExp)i=t,e=1;else{var n=mu[t];i=void 0!==n?n:new RegExp(t),e=t.length}return[i,e]}}]),t}(),wu=function(){function t(e,i,n,o){var r=this;Nn(this,t),this.ctx=e,this.parent=i,this.selected=n,this.hover=o;this.lines=new yu((function(t,i){if(void 0===t)return 0;var s=r.parent.getFormattingValues(e,n,o,i),a=0;""!==t&&(a=r.ctx.measureText(t).width);return{width:a,values:s}}))}return Fn(t,[{key:"process",value:function(t){if(!vu(t))return this.lines.finalize();var e=this.parent.fontOptions;t=(t=t.replace(/\r\n/g,"\n")).replace(/\r/g,"\n");var i=String(t).split("\n"),n=i.length;if(e.multi)for(var o=0;o<n;o++){var r=this.splitBlocks(i[o],e.multi);if(void 0!==r)if(0!==r.length){if(e.maxWdt>0)for(var s=0;s<r.length;s++){var a=r[s].mod,h=r[s].text;this.splitStringIntoLines(h,a,!0)}else for(var l=0;l<r.length;l++){var d=r[l].mod,c=r[l].text;this.lines.append(c,d)}this.lines.newLine()}else this.lines.newLine("")}else if(e.maxWdt>0)for(var u=0;u<n;u++)this.splitStringIntoLines(i[u]);else for(var f=0;f<n;f++)this.lines.newLine(i[f]);return this.lines.finalize()}},{key:"decodeMarkupSystem",value:function(t){var e="none";return"markdown"===t||"md"===t?e="markdown":!0!==t&&"html"!==t||(e="html"),e}},{key:"splitHtmlBlocks",value:function(t){for(var e=new bu(t),i=function(t){return!!/&/.test(t)&&(e.replace(e.text,"&lt;","<")||e.replace(e.text,"&amp;","&")||e.add("&"),!0)};e.position<e.text.length;){var n=e.text.charAt(e.position);e.parseWS(n)||/</.test(n)&&(e.parseStartTag("bold","<b>")||e.parseStartTag("ital","<i>")||e.parseStartTag("mono","<code>")||e.parseEndTag("bold","</b>")||e.parseEndTag("ital","</i>")||e.parseEndTag("mono","</code>"))||i(n)||e.add(n),e.position++}return e.emitBlock(),e.blocks}},{key:"splitMarkdownBlocks",value:function(t){for(var e=this,i=new bu(t),n=!0,o=function(t){return!!/\\/.test(t)&&(i.position<e.text.length+1&&(i.position++,t=e.text.charAt(i.position),/ \t/.test(t)?i.spacing=!0:(i.add(t),n=!1)),!0)};i.position<i.text.length;){var r=i.text.charAt(i.position);i.parseWS(r)||o(r)||(n||i.spacing)&&(i.parseStartTag("bold","*")||i.parseStartTag("ital","_")||i.parseStartTag("mono","`"))||i.parseEndTag("bold","*","afterBold")||i.parseEndTag("ital","_","afterItal")||i.parseEndTag("mono","`","afterMono")||(i.add(r),n=!1),i.position++}return i.emitBlock(),i.blocks}},{key:"splitBlocks",value:function(t,e){var i=this.decodeMarkupSystem(e);return"none"===i?[{text:t,mod:"normal"}]:"markdown"===i?this.splitMarkdownBlocks(t):"html"===i?this.splitHtmlBlocks(t):void 0}},{key:"overMaxWidth",value:function(t){var e=this.ctx.measureText(t).width;return this.lines.curWidth()+e>this.parent.fontOptions.maxWdt}},{key:"getLongestFit",value:function(t){for(var e="",i=0;i<t.length;){var n=e+(""===e?"":" ")+t[i];if(this.overMaxWidth(n))break;e=n,i++}return i}},{key:"getLongestFitWord",value:function(t){for(var e=0;e<t.length&&!this.overMaxWidth(Oo(t).call(t,0,e));)e++;return e}},{key:"splitStringIntoLines",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"normal",i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];this.parent.getFormattingValues(this.ctx,this.selected,this.hover,e);for(var n=(t=(t=t.replace(/^( +)/g,"$1\r")).replace(/([^\r][^ ]*)( +)/g,"$1\r$2\r")).split("\r");n.length>0;){var o=this.getLongestFit(n);if(0===o){var r=n[0],s=this.getLongestFitWord(r);this.lines.newLine(Oo(r).call(r,0,s),e),n[0]=Oo(r).call(r,s)}else{var a=o;" "===n[o-1]?o--:" "===n[a]&&a++;var h=Oo(n).call(n,0,o).join("");o==n.length&&i?this.lines.append(h,e):this.lines.newLine(h,e),n=Oo(n).call(n,a)}}}}]),t}(),ku=["bold","ital","boldital","mono"],_u=function(){function t(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2];Nn(this,t),this.body=e,this.pointToSelf=!1,this.baseSize=void 0,this.fontOptions={},this.setOptions(i),this.size={top:0,left:0,width:0,height:0,yLine:0},this.isEdgeLabel=n}return Fn(t,[{key:"setOptions",value:function(t){if(this.elementOptions=t,this.initFontOptions(t.font),vu(t.label)?this.labelDirty=!0:t.label=void 0,void 0!==t.font&&null!==t.font)if("string"==typeof t.font)this.baseSize=this.fontOptions.size;else if("object"===go(t.font)){var e=t.font.size;void 0!==e&&(this.baseSize=e)}}},{key:"initFontOptions",value:function(e){var i=this;Dh(ku,(function(t){i.fontOptions[t]={}})),t.parseFontString(this.fontOptions,e)?this.fontOptions.vadjust=0:Dh(e,(function(t,e){null!=t&&"object"!==go(t)&&(i.fontOptions[e]=t)}))}},{key:"constrain",value:function(t){var e={constrainWidth:!1,maxWdt:-1,minWdt:-1,constrainHeight:!1,minHgt:-1,valign:"middle"},i=Qh(t,"widthConstraint");if("number"==typeof i)e.maxWdt=Number(i),e.minWdt=Number(i);else if("object"===go(i)){var n=Qh(t,["widthConstraint","maximum"]);"number"==typeof n&&(e.maxWdt=Number(n));var o=Qh(t,["widthConstraint","minimum"]);"number"==typeof o&&(e.minWdt=Number(o))}var r=Qh(t,"heightConstraint");if("number"==typeof r)e.minHgt=Number(r);else if("object"===go(r)){var s=Qh(t,["heightConstraint","minimum"]);"number"==typeof s&&(e.minHgt=Number(s));var a=Qh(t,["heightConstraint","valign"]);"string"==typeof a&&("top"!==a&&"bottom"!==a||(e.valign=a))}return e}},{key:"update",value:function(t,e){this.setOptions(t,!0),this.propagateFonts(e),Ch(this.fontOptions,this.constrain(e)),this.fontOptions.chooser=fu("label",e)}},{key:"adjustSizes",value:function(t){var e=t?t.right+t.left:0;this.fontOptions.constrainWidth&&(this.fontOptions.maxWdt-=e,this.fontOptions.minWdt-=e);var i=t?t.top+t.bottom:0;this.fontOptions.constrainHeight&&(this.fontOptions.minHgt-=i)}},{key:"addFontOptionsToPile",value:function(t,e){for(var i=0;i<e.length;++i)this.addFontToPile(t,e[i])}},{key:"addFontToPile",value:function(t,e){if(void 0!==e&&void 0!==e.font&&null!==e.font){var i=e.font;t.push(i)}}},{key:"getBasicOptions",value:function(e){for(var i={},n=0;n<e.length;++n){var o=e[n],r={};t.parseFontString(r,o)&&(o=r),Dh(o,(function(t,e){void 0!==t&&(Object.prototype.hasOwnProperty.call(i,e)||(-1!==Hr(ku).call(ku,e)?i[e]={}:i[e]=t))}))}return i}},{key:"getFontOption",value:function(e,i,n){for(var o,r=0;r<e.length;++r){var s=e[r];if(Object.prototype.hasOwnProperty.call(s,i)){if(null==(o=s[i]))continue;var a={};if(t.parseFontString(a,o)&&(o=a),Object.prototype.hasOwnProperty.call(o,n))return o[n]}}if(Object.prototype.hasOwnProperty.call(this.fontOptions,n))return this.fontOptions[n];throw new Error("Did not find value for multi-font for property: '"+n+"'")}},{key:"getFontOptions",value:function(t,e){for(var i={},n=["color","size","face","mod","vadjust"],o=0;o<n.length;++o){var r=n[o];i[r]=this.getFontOption(t,e,r)}return i}},{key:"propagateFonts",value:function(t){var e=this,i=[];this.addFontOptionsToPile(i,t),this.fontOptions=this.getBasicOptions(i);for(var n=function(t){var n=ku[t],o=e.fontOptions[n];Dh(e.getFontOptions(i,n),(function(t,e){o[e]=t})),o.size=Number(o.size),o.vadjust=Number(o.vadjust)},o=0;o<ku.length;++o)n(o)}},{key:"draw",value:function(t,e,i,n,o){var r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";if(void 0!==this.elementOptions.label){var s=this.fontOptions.size*this.body.view.scale;this.elementOptions.label&&s<this.elementOptions.scaling.label.drawThreshold-1||(s>=this.elementOptions.scaling.label.maxVisible&&(s=Number(this.elementOptions.scaling.label.maxVisible)/this.body.view.scale),this.calculateLabelSize(t,n,o,e,i,r),this._drawBackground(t),this._drawText(t,e,this.size.yLine,r,s))}}},{key:"_drawBackground",value:function(t){if(void 0!==this.fontOptions.background&&"none"!==this.fontOptions.background){t.fillStyle=this.fontOptions.background;var e=this.getSize();t.fillRect(e.left,e.top,e.width,e.height)}}},{key:"_drawText",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"middle",o=arguments.length>4?arguments[4]:void 0,r=this._setAlignment(t,e,i,n),s=uo(r,2);e=s[0],i=s[1],t.textAlign="left",e-=this.size.width/2,this.fontOptions.valign&&this.size.height>this.size.labelHeight&&("top"===this.fontOptions.valign&&(i-=(this.size.height-this.size.labelHeight)/2),"bottom"===this.fontOptions.valign&&(i+=(this.size.height-this.size.labelHeight)/2));for(var a=0;a<this.lineCount;a++){var h=this.lines[a];if(h&&h.blocks){var l=0;this.isEdgeLabel||"center"===this.fontOptions.align?l+=(this.size.width-h.width)/2:"right"===this.fontOptions.align&&(l+=this.size.width-h.width);for(var d=0;d<h.blocks.length;d++){var c=h.blocks[d];t.font=c.font;var u=this._getColor(c.color,o,c.strokeColor),f=uo(u,2),p=f[0],v=f[1];c.strokeWidth>0&&(t.lineWidth=c.strokeWidth,t.strokeStyle=v,t.lineJoin="round"),t.fillStyle=p,c.strokeWidth>0&&t.strokeText(c.text,e+l,i+c.vadjust),t.fillText(c.text,e+l,i+c.vadjust),l+=c.width}i+=h.height}}}},{key:"_setAlignment",value:function(t,e,i,n){if(this.isEdgeLabel&&"horizontal"!==this.fontOptions.align&&!1===this.pointToSelf){e=0,i=0;"top"===this.fontOptions.align?(t.textBaseline="alphabetic",i-=4):"bottom"===this.fontOptions.align?(t.textBaseline="hanging",i+=4):t.textBaseline="middle"}else t.textBaseline=n;return[e,i]}},{key:"_getColor",value:function(t,e,i){var n=t||"#000000",o=i||"#ffffff";if(e<=this.elementOptions.scaling.label.drawThreshold){var r=Math.max(0,Math.min(1,1-(this.elementOptions.scaling.label.drawThreshold-e)));n=Fh(n,r),o=Fh(o,r)}return[n,o]}},{key:"getTextSize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];return this._processLabel(t,e,i),{width:this.size.width,height:this.size.height,lineCount:this.lineCount}}},{key:"getSize",value:function(){var t=this.size.left,e=this.size.top-1;if(this.isEdgeLabel){var i=.5*-this.size.width;switch(this.fontOptions.align){case"middle":t=i,e=.5*-this.size.height;break;case"top":t=i,e=-(this.size.height+2);break;case"bottom":t=i,e=2}}return{left:t,top:e,width:this.size.width,height:this.size.height}}},{key:"calculateLabelSize",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:0,r=arguments.length>5&&void 0!==arguments[5]?arguments[5]:"middle";this._processLabel(t,e,i),this.size.left=n-.5*this.size.width,this.size.top=o-.5*this.size.height,this.size.yLine=o+.5*(1-this.lineCount)*this.fontOptions.size,"hanging"===r&&(this.size.top+=.5*this.fontOptions.size,this.size.top+=4,this.size.yLine+=4)}},{key:"getFormattingValues",value:function(t,e,i,n){var o=function(t,e,i){return"normal"===e?"mod"===i?"":t[i]:void 0!==t[e][i]?t[e][i]:t[i]},r={color:o(this.fontOptions,n,"color"),size:o(this.fontOptions,n,"size"),face:o(this.fontOptions,n,"face"),mod:o(this.fontOptions,n,"mod"),vadjust:o(this.fontOptions,n,"vadjust"),strokeWidth:this.fontOptions.strokeWidth,strokeColor:this.fontOptions.strokeColor};(e||i)&&("normal"===n&&!0===this.fontOptions.chooser&&this.elementOptions.labelHighlightBold?r.mod="bold":"function"==typeof this.fontOptions.chooser&&this.fontOptions.chooser(r,this.elementOptions.id,e,i));var s="";return void 0!==r.mod&&""!==r.mod&&(s+=r.mod+" "),s+=r.size+"px "+r.face,t.font=s.replace(/"/g,""),r.font=t.font,r.height=r.size,r}},{key:"differentState",value:function(t,e){return t!==this.selectedState||e!==this.hoverState}},{key:"_processLabelText",value:function(t,e,i,n){return new wu(t,this,e,i).process(n)}},{key:"_processLabel",value:function(t,e,i){if(!1!==this.labelDirty||this.differentState(e,i)){var n=this._processLabelText(t,e,i,this.elementOptions.label);this.fontOptions.minWdt>0&&n.width<this.fontOptions.minWdt&&(n.width=this.fontOptions.minWdt),this.size.labelHeight=n.height,this.fontOptions.minHgt>0&&n.height<this.fontOptions.minHgt&&(n.height=this.fontOptions.minHgt),this.lines=n.lines,this.lineCount=n.lines.length,this.size.width=n.width,this.size.height=n.height,this.selectedState=e,this.hoverState=i,this.labelDirty=!1}}},{key:"visible",value:function(){return 0!==this.size.width&&0!==this.size.height&&void 0!==this.elementOptions.label&&!(this.fontOptions.size*this.body.view.scale<this.elementOptions.scaling.label.drawThreshold-1)}}],[{key:"parseFontString",value:function(t,e){if(!e||"string"!=typeof e)return!1;var i=e.split(" ");return t.size=+i[0].replace("px",""),t.face=i[1],t.color=i[2],!0}}]),t}(),xu=function(){function t(e,i,n){Nn(this,t),this.body=i,this.labelModule=n,this.setOptions(e),this.top=void 0,this.left=void 0,this.height=void 0,this.width=void 0,this.radius=void 0,this.margin=void 0,this.refreshNeeded=!0,this.boundingBox={top:0,left:0,right:0,bottom:0}}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"_setMargins",value:function(t){this.margin={},this.options.margin&&("object"==go(this.options.margin)?(this.margin.top=this.options.margin.top,this.margin.right=this.options.margin.right,this.margin.bottom=this.options.margin.bottom,this.margin.left=this.options.margin.left):(this.margin.top=this.options.margin,this.margin.right=this.options.margin,this.margin.bottom=this.options.margin,this.margin.left=this.options.margin)),t.adjustSizes(this.margin)}},{key:"_distanceToBorder",value:function(t,e){var i=this.options.borderWidth;return t&&this.resize(t),Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}},{key:"enableShadow",value:function(t,e){e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"enableBorderDashes",value:function(t,e){if(!1!==e.borderDashes)if(void 0!==t.setLineDash){var i=e.borderDashes;!0===i&&(i=[5,15]),t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1}},{key:"disableBorderDashes",value:function(t,e){!1!==e.borderDashes&&(void 0!==t.setLineDash?t.setLineDash([0]):(console.warn("setLineDash is not supported in this browser. The dashed borders cannot be used."),this.options.shapeProperties.borderDashes=!1,e.borderDashes=!1))}},{key:"needsRefresh",value:function(t,e){return!0===this.refreshNeeded?(this.refreshNeeded=!1,!0):void 0===this.width||this.labelModule.differentState(t,e)}},{key:"initContextForDraw",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.lineWidth=Math.min(this.width,i),t.strokeStyle=e.borderColor,t.fillStyle=e.color}},{key:"performStroke",value:function(t,e){var i=e.borderWidth/this.body.view.scale;t.save(),i>0&&(this.enableBorderDashes(t,e),t.stroke(),this.disableBorderDashes(t,e)),t.restore()}},{key:"performFill",value:function(t,e){t.save(),t.fillStyle=e.color,this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e),t.restore(),this.performStroke(t,e)}},{key:"_addBoundingBoxMargin",value:function(t){this.boundingBox.left-=t,this.boundingBox.top-=t,this.boundingBox.bottom+=t,this.boundingBox.right+=t}},{key:"_updateBoundingBox",value:function(t,e,i,n,o){void 0!==i&&this.resize(i,n,o),this.left=t-this.width/2,this.top=e-this.height/2,this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o)}},{key:"getDimensionsFromLabel",value:function(t,e,i){this.textSize=this.labelModule.getTextSize(t,e,i);var n=this.textSize.width,o=this.textSize.height;return 0===n&&(n=14,o=14),{width:n,height:o}}}]),t}();function Eu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ou=function(t){Ad(i,t);var e=Eu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.width=n.width+this.margin.right+this.margin.left,this.height=n.height+this.margin.top+this.margin.bottom,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Yt(t,this.left,this.top,this.width,this.height,r.borderRadius),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"updateBoundingBox",value:function(t,e,i,n,o){this._updateBoundingBox(t,e,i,n,o);var r=this.options.shapeProperties.borderRadius;this._addBoundingBoxMargin(r)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=this.options.borderWidth;return Math.min(Math.abs(this.width/2/Math.cos(e)),Math.abs(this.height/2/Math.sin(e)))+i}}]),i}(xu);function Cu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Su=function(t){Ad(i,t);var e=Cu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).labelOffset=0,r.selected=!1,r}return Fn(i,[{key:"setOptions",value:function(t,e,i){this.options=t,void 0===e&&void 0===i||this.setImages(e,i)}},{key:"setImages",value:function(t,e){e&&this.selected?(this.imageObj=e,this.imageObjAlt=t):(this.imageObj=t,this.imageObjAlt=e)}},{key:"switchImages",value:function(t){var e=t&&!this.selected||!t&&this.selected;if(this.selected=t,void 0!==this.imageObjAlt&&e){var i=this.imageObj;this.imageObj=this.imageObjAlt,this.imageObjAlt=i}}},{key:"_getImagePadding",value:function(){var t={top:0,right:0,bottom:0,left:0};if(this.options.imagePadding){var e=this.options.imagePadding;"object"==go(e)?(t.top=e.top,t.right=e.right,t.bottom=e.bottom,t.left=e.left):(t.top=e,t.right=e,t.bottom=e,t.left=e)}return t}},{key:"_resizeImage",value:function(){var t,e;if(!1===this.options.shapeProperties.useImageSize){var i=1,n=1;this.imageObj.width&&this.imageObj.height&&(this.imageObj.width>this.imageObj.height?i=this.imageObj.width/this.imageObj.height:n=this.imageObj.height/this.imageObj.width),t=2*this.options.size*i,e=2*this.options.size*n}else{var o=this._getImagePadding();t=this.imageObj.width+o.left+o.right,e=this.imageObj.height+o.top+o.bottom}this.width=t,this.height=e,this.radius=.5*this.width}},{key:"_drawRawCircle",value:function(t,e,i,n){this.initContextForDraw(t,n),Ut(t,e,i,n.size),this.performFill(t,n)}},{key:"_drawImageAtPosition",value:function(t,e){if(0!=this.imageObj.width){t.globalAlpha=void 0!==e.opacity?e.opacity:1,this.enableShadow(t,e);var i=1;!0===this.options.shapeProperties.interpolation&&(i=this.imageObj.width/this.width/this.body.view.scale);var n=this._getImagePadding(),o=this.left+n.left,r=this.top+n.top,s=this.width-n.left-n.right,a=this.height-n.top-n.bottom;this.imageObj.drawImageAtPosition(t,i,o,r,s,a),this.disableShadow(t,e)}}},{key:"_drawImageLabel",value:function(t,e,i,n,o){var r=0;if(void 0!==this.height){r=.5*this.height;var s=this.labelModule.getTextSize(t,n,o);s.lineCount>=1&&(r+=s.height/2)}var a=i+r;this.options.label&&(this.labelOffset=r),this.labelModule.draw(t,e,a,n,o,"hanging")}}]),i}(xu);function Tu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Mu=function(t){Ad(i,t);var e=Tu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i),o=Math.max(n.width+this.margin.right+this.margin.left,n.height+this.margin.top+this.margin.bottom);this.options.size=o/2,this.width=o,this.height=o,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this._drawRawCircle(t,e,i,r),this.updateBoundingBox(e,i),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,i,n,o)}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Pu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Du=function(t){Ad(i,t);var e=Pu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,this.height=o,void(this.radius=.5*this.width)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){this.switchImages(n),this.resize();var s=e,a=i;"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),this._drawRawCircle(t,s,a,r),t.save(),t.clip(),this._drawImageAtPosition(t,r),t.restore(),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i)}},{key:"updateBoundingBox",value:function(t,e){"top-left"===this.options.shapeProperties.coordinateOrigin?(this.boundingBox.top=e,this.boundingBox.left=t,this.boundingBox.right=t+2*this.options.size,this.boundingBox.bottom=e+2*this.options.size):(this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size),this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),.5*this.width}}]),i}(Su);function Iu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Bu=function(t){Ad(i,t);var e=Iu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{size:this.options.size};if(this.needsRefresh(e,i)){var o,r;this.labelModule.getTextSize(t,e,i);var s=2*n.size;this.width=null!==(o=this.customSizeWidth)&&void 0!==o?o:s,this.height=null!==(r=this.customSizeHeight)&&void 0!==r?r:s,this.radius=.5*this.width}}},{key:"_drawShape",value:function(t,e,i,n,o,r,s,a){var h,l=this;return this.resize(t,r,s,a),this.left=n-this.width/2,this.top=o-this.height/2,this.initContextForDraw(t,a),(h=e,Object.prototype.hasOwnProperty.call($t,h)?$t[h]:function(t){for(var e=arguments.length,i=new Array(e>1?e-1:0),n=1;n<e;n++)i[n-1]=arguments[n];CanvasRenderingContext2D.prototype[h].call(t,i)})(t,n,o,a.size),this.performFill(t,a),void 0!==this.options.icon&&void 0!==this.options.icon.code&&(t.font=(r?"bold ":"")+this.height/2+"px "+(this.options.icon.face||"FontAwesome"),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",t.fillText(this.options.icon.code,n,o)),{drawExternalLabel:function(){if(void 0!==l.options.label){l.labelModule.calculateLabelSize(t,r,s,n,o,"hanging");var e=o+.5*l.height+.5*l.labelModule.size.height;l.labelModule.draw(t,n,e,r,s,"hanging")}l.updateBoundingBox(n,o)}}}},{key:"updateBoundingBox",value:function(t,e){this.boundingBox.top=e-this.options.size,this.boundingBox.left=t-this.options.size,this.boundingBox.right=t+this.options.size,this.boundingBox.bottom=e+this.options.size,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height))}}]),i}(xu);function zu(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Nu(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=zu(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=zu(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Au(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Fu=function(t){Ad(i,t);var e=Au(i);function i(t,n,o,r){var s;return Nn(this,i),(s=e.call(this,t,n,o,r)).ctxRenderer=r,s}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o,r),this.left=e-this.width/2,this.top=i-this.height/2,t.save();var s=this.ctxRenderer({ctx:t,id:this.options.id,x:e,y:i,state:{selected:n,hover:o},style:Nu({},r),label:this.options.label});if(null!=s.drawNode&&s.drawNode(),t.restore(),s.drawExternalLabel){var a=s.drawExternalLabel;s.drawExternalLabel=function(){t.save(),a(),t.restore()}}return s.nodeDimensions&&(this.customSizeWidth=s.nodeDimensions.width,this.customSizeHeight=s.nodeDimensions.height),s}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function ju(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ru=function(t){Ad(i,t);var e=ju(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i).width+this.margin.right+this.margin.left;this.width=n,this.height=n,this.radius=this.width/2}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.initContextForDraw(t,r),Gt(t,e-this.width/2,i-this.height/2,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Lu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Hu=function(t){Ad(i,t);var e=Lu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"diamond",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Wu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var qu=function(t){Ad(i,t);var e=Wu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"circle",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t){return t&&this.resize(t),this.options.size}}]),i}(Bu);function Vu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uu=function(t){Ad(i,t);var e=Vu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover;if(this.needsRefresh(e,i)){var n=this.getDimensionsFromLabel(t,e,i);this.height=2*n.height,this.width=n.width+n.height,this.radius=.5*this.width}}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-.5*this.width,this.top=i-.5*this.height,this.initContextForDraw(t,r),Xt(t,this.left,this.top,this.width,this.height),this.performFill(t,r),this.updateBoundingBox(e,i,t,n,o),this.labelModule.draw(t,e,i,n,o)}},{key:"distanceToBorder",value:function(t,e){t&&this.resize(t);var i=.5*this.width,n=.5*this.height,o=Math.sin(e)*i,r=Math.cos(e)*n;return i*n/Math.sqrt(o*o+r*r)}}]),i}(xu);function Yu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xu=function(t){Ad(i,t);var e=Yu(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.iconSize={width:Number(this.options.icon.size),height:Number(this.options.icon.size)},this.width=this.iconSize.width+this.margin.right+this.margin.left,this.height=this.iconSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){var s=this;return this.resize(t,n,o),this.options.icon.size=this.options.icon.size||50,this.left=e-this.width/2,this.top=i-this.height/2,this._icon(t,e,i,n,o,r),{drawExternalLabel:function(){if(void 0!==s.options.label){s.labelModule.draw(t,s.left+s.iconSize.width/2+s.margin.left,i+s.height/2+5,n)}s.updateBoundingBox(e,i)}}}},{key:"updateBoundingBox",value:function(t,e){if(this.boundingBox.top=e-.5*this.options.icon.size,this.boundingBox.left=t-.5*this.options.icon.size,this.boundingBox.right=t+.5*this.options.icon.size,this.boundingBox.bottom=e+.5*this.options.icon.size,void 0!==this.options.label&&this.labelModule.size.width>0){this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelModule.size.height+5)}}},{key:"_icon",value:function(t,e,i,n,o,r){var s=Number(this.options.icon.size);void 0!==this.options.icon.code?(t.font=[null!=this.options.icon.weight?this.options.icon.weight:n?"bold":"",(null!=this.options.icon.weight&&n?5:0)+s+"px",this.options.icon.face].join(" "),t.fillStyle=this.options.icon.color||"black",t.textAlign="center",t.textBaseline="middle",this.enableShadow(t,r),t.fillText(this.options.icon.code,e,i),this.disableShadow(t,r)):console.error("When using the icon shape, you need to define the code in the icon options object. This can be done per node or globally.")}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function Gu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ku=function(t){Ad(i,t);var e=Gu(i);function i(t,n,o,r,s){var a;return Nn(this,i),(a=e.call(this,t,n,o)).setImages(r,s),a}return Fn(i,[{key:"resize",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.selected,i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this.hover,n=void 0===this.imageObj.src||void 0===this.imageObj.width||void 0===this.imageObj.height;if(n){var o=2*this.options.size;return this.width=o,void(this.height=o)}this.needsRefresh(e,i)&&this._resizeImage()}},{key:"draw",value:function(t,e,i,n,o,r){t.save(),this.switchImages(n),this.resize();var s=e,a=i;if("top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=e,this.top=i,s+=this.width/2,a+=this.height/2):(this.left=e-this.width/2,this.top=i-this.height/2),!0===this.options.shapeProperties.useBorderWithImage){var h=this.options.borderWidth,l=this.options.borderWidthSelected||2*this.options.borderWidth,d=(n?l:h)/this.body.view.scale;t.lineWidth=Math.min(this.width,d),t.beginPath();var c=n?this.options.color.highlight.border:o?this.options.color.hover.border:this.options.color.border,u=n?this.options.color.highlight.background:o?this.options.color.hover.background:this.options.color.background;void 0!==r.opacity&&(c=Fh(c,r.opacity),u=Fh(u,r.opacity)),t.strokeStyle=c,t.fillStyle=u,t.rect(this.left-.5*t.lineWidth,this.top-.5*t.lineWidth,this.width+t.lineWidth,this.height+t.lineWidth),hs(t).call(t),this.performStroke(t,r),t.closePath()}this._drawImageAtPosition(t,r),this._drawImageLabel(t,s,a,n,o),this.updateBoundingBox(e,i),t.restore()}},{key:"updateBoundingBox",value:function(t,e){this.resize(),"top-left"===this.options.shapeProperties.coordinateOrigin?(this.left=t,this.top=e):(this.left=t-this.width/2,this.top=e-this.height/2),this.boundingBox.left=this.left,this.boundingBox.top=this.top,this.boundingBox.bottom=this.top+this.height,this.boundingBox.right=this.left+this.width,void 0!==this.options.label&&this.labelModule.size.width>0&&(this.boundingBox.left=Math.min(this.boundingBox.left,this.labelModule.size.left),this.boundingBox.right=Math.max(this.boundingBox.right,this.labelModule.size.left+this.labelModule.size.width),this.boundingBox.bottom=Math.max(this.boundingBox.bottom,this.boundingBox.bottom+this.labelOffset))}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Su);function $u(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Zu=function(t){Ad(i,t);var e=$u(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"square",2,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function Qu(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Ju=function(t){Ad(i,t);var e=Qu(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"hexagon",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function tf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var ef=function(t){Ad(i,t);var e=tf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"star",4,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function nf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var of=function(t){Ad(i,t);var e=nf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._setMargins(o),r}return Fn(i,[{key:"resize",value:function(t,e,i){this.needsRefresh(e,i)&&(this.textSize=this.labelModule.getTextSize(t,e,i),this.width=this.textSize.width+this.margin.right+this.margin.left,this.height=this.textSize.height+this.margin.top+this.margin.bottom,this.radius=.5*this.width)}},{key:"draw",value:function(t,e,i,n,o,r){this.resize(t,n,o),this.left=e-this.width/2,this.top=i-this.height/2,this.enableShadow(t,r),this.labelModule.draw(t,this.left+this.textSize.width/2+this.margin.left,this.top+this.textSize.height/2+this.margin.top,n,o),this.disableShadow(t,r),this.updateBoundingBox(e,i,t,n,o)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(xu);function rf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var sf=function(t){Ad(i,t);var e=rf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangle",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function af(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var hf=function(t){Ad(i,t);var e=af(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"draw",value:function(t,e,i,n,o,r){return this._drawShape(t,"triangleDown",3,e,i,n,o,r)}},{key:"distanceToBorder",value:function(t,e){return this._distanceToBorder(t,e)}}]),i}(Bu);function lf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function df(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=lf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=lf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var cf=function(){function t(e,i,n,o,r,s){Nn(this,t),this.options=Kh(r),this.globalOptions=r,this.defaultOptions=s,this.body=i,this.edges=[],this.id=void 0,this.imagelist=n,this.grouplist=o,this.x=void 0,this.y=void 0,this.baseSize=this.options.size,this.baseFontSize=this.options.font.size,this.predefinedPosition=!1,this.selected=!1,this.hover=!1,this.labelModule=new _u(this.body,this.options,!1),this.setOptions(e)}return Fn(t,[{key:"attachEdge",value:function(t){var e;-1===Hr(e=this.edges).call(e,t)&&this.edges.push(t)}},{key:"detachEdge",value:function(t){var e,i,n=Hr(e=this.edges).call(e,t);-1!=n&&er(i=this.edges).call(i,n,1)}},{key:"setOptions",value:function(e){var i=this.options.shape;if(e){if(void 0!==e.color&&(this._localColor=e.color),void 0!==e.id&&(this.id=e.id),void 0===this.id)throw new Error("Node must have an id");t.checkMass(e,this.id),void 0!==e.x&&(null===e.x?(this.x=void 0,this.predefinedPosition=!1):(this.x=Br(e.x),this.predefinedPosition=!0)),void 0!==e.y&&(null===e.y?(this.y=void 0,this.predefinedPosition=!1):(this.y=Br(e.y),this.predefinedPosition=!0)),void 0!==e.size&&(this.baseSize=e.size),void 0!==e.value&&(e.value=hu(e.value)),t.parseOptions(this.options,e,!0,this.globalOptions,this.grouplist);var n=[e,this.options,this.defaultOptions];return this.chooser=fu("node",n),this._load_images(),this.updateLabelModule(e),void 0!==e.opacity&&t.checkOpacity(e.opacity)&&(this.options.opacity=e.opacity),this.updateShape(i),void 0!==e.hidden||void 0!==e.physics}}},{key:"_load_images",value:function(){if(("circularImage"===this.options.shape||"image"===this.options.shape)&&void 0===this.options.image)throw new Error("Option image must be defined for node type '"+this.options.shape+"'");if(void 0!==this.options.image){if(void 0===this.imagelist)throw new Error("Internal Error: No images provided");if("string"==typeof this.options.image)this.imageObj=this.imagelist.load(this.options.image,this.options.brokenImage,this.id);else{if(void 0===this.options.image.unselected)throw new Error("No unselected image provided");this.imageObj=this.imagelist.load(this.options.image.unselected,this.options.brokenImage,this.id),void 0!==this.options.image.selected?this.imageObjAlt=this.imagelist.load(this.options.image.selected,this.options.brokenImage,this.id):this.imageObjAlt=void 0}}}},{key:"getFormattingValues",value:function(){var t={color:this.options.color.background,opacity:this.options.opacity,borderWidth:this.options.borderWidth,borderColor:this.options.color.border,size:this.options.size,borderDashes:this.options.shapeProperties.borderDashes,borderRadius:this.options.shapeProperties.borderRadius,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y};if(this.selected||this.hover?!0===this.chooser?this.selected?(null!=this.options.borderWidthSelected?t.borderWidth=this.options.borderWidthSelected:t.borderWidth*=2,t.color=this.options.color.highlight.background,t.borderColor=this.options.color.highlight.border,t.shadow=this.options.shadow.enabled):this.hover&&(t.color=this.options.color.hover.background,t.borderColor=this.options.color.hover.border,t.shadow=this.options.shadow.enabled):"function"==typeof this.chooser&&(this.chooser(t,this.options.id,this.selected,this.hover),!1===t.shadow&&(t.shadowColor===this.options.shadow.color&&t.shadowSize===this.options.shadow.size&&t.shadowX===this.options.shadow.x&&t.shadowY===this.options.shadow.y||(t.shadow=!0))):t.shadow=this.options.shadow.enabled,void 0!==this.options.opacity){var e=this.options.opacity;t.borderColor=Fh(t.borderColor,e),t.color=Fh(t.color,e),t.shadowColor=Fh(t.shadowColor,e)}return t}},{key:"updateLabelModule",value:function(e){void 0!==this.options.label&&null!==this.options.label||(this.options.label=""),t.updateGroupOptions(this.options,df(df({},e),{},{color:e&&e.color||this._localColor||void 0}),this.grouplist);var i=this.grouplist.get(this.options.group,!1),n=[e,this.options,i,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,n),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateShape",value:function(t){if(t===this.options.shape&&this.shape)this.shape.setOptions(this.options,this.imageObj,this.imageObjAlt);else switch(this.options.shape){case"box":this.shape=new Ou(this.options,this.body,this.labelModule);break;case"circle":this.shape=new Mu(this.options,this.body,this.labelModule);break;case"circularImage":this.shape=new Du(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"custom":this.shape=new Fu(this.options,this.body,this.labelModule,this.options.ctxRenderer);break;case"database":this.shape=new Ru(this.options,this.body,this.labelModule);break;case"diamond":this.shape=new Hu(this.options,this.body,this.labelModule);break;case"dot":this.shape=new qu(this.options,this.body,this.labelModule);break;case"ellipse":this.shape=new Uu(this.options,this.body,this.labelModule);break;case"icon":this.shape=new Xu(this.options,this.body,this.labelModule);break;case"image":this.shape=new Ku(this.options,this.body,this.labelModule,this.imageObj,this.imageObjAlt);break;case"square":this.shape=new Zu(this.options,this.body,this.labelModule);break;case"hexagon":this.shape=new Ju(this.options,this.body,this.labelModule);break;case"star":this.shape=new ef(this.options,this.body,this.labelModule);break;case"text":this.shape=new of(this.options,this.body,this.labelModule);break;case"triangle":this.shape=new sf(this.options,this.body,this.labelModule);break;case"triangleDown":this.shape=new hf(this.options,this.body,this.labelModule);break;default:this.shape=new Uu(this.options,this.body,this.labelModule)}this.needsRefresh()}},{key:"select",value:function(){this.selected=!0,this.needsRefresh()}},{key:"unselect",value:function(){this.selected=!1,this.needsRefresh()}},{key:"needsRefresh",value:function(){this.shape.refreshNeeded=!0}},{key:"getTitle",value:function(){return this.options.title}},{key:"distanceToBorder",value:function(t,e){return this.shape.distanceToBorder(t,e)}},{key:"isFixed",value:function(){return this.options.fixed.x&&this.options.fixed.y}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"getLabelSize",value:function(){return this.labelModule.size()}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.size=this.options.scaling.min+n*o}else this.options.size=this.baseSize,this.options.font.size=this.baseFontSize;this.updateLabelModule()}},{key:"draw",value:function(t){var e=this.getFormattingValues();return this.shape.draw(t,this.x,this.y,this.selected,this.hover,e)||{}}},{key:"updateBoundingBox",value:function(t){this.shape.updateBoundingBox(this.x,this.y,t)}},{key:"resize",value:function(t){var e=this.getFormattingValues();this.shape.resize(t,this.selected,this.hover,e)}},{key:"getItemsOnPoint",value:function(t){var e=[];return this.labelModule.visible()&&pu(this.labelModule.getSize(),t)&&e.push({nodeId:this.id,labelId:0}),pu(this.shape.boundingBox,t)&&e.push({nodeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){return this.shape.left<t.right&&this.shape.left+this.shape.width>t.left&&this.shape.top<t.bottom&&this.shape.top+this.shape.height>t.top}},{key:"isBoundingBoxOverlappingWith",value:function(t){return this.shape.boundingBox.left<t.right&&this.shape.boundingBox.right>t.left&&this.shape.boundingBox.top<t.bottom&&this.shape.boundingBox.bottom>t.top}}],[{key:"checkOpacity",value:function(t){return 0<=t&&t<=1}},{key:"checkCoordinateOrigin",value:function(t){return void 0===t||"center"===t||"top-left"===t}},{key:"updateGroupOptions",value:function(e,i,n){var o;if(void 0!==n){var r=e.group;if(void 0!==i&&void 0!==i.group&&r!==i.group)throw new Error("updateGroupOptions: group values in options don't match.");if("number"==typeof r||"string"==typeof r&&""!=r){var s=n.get(r);void 0!==s.opacity&&void 0===i.opacity&&(t.checkOpacity(s.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+s.opacity),s.opacity=void 0));var a=mr(o=uu(i)).call(o,(function(t){return null!=i[t]}));a.push("font"),Oh(a,e,s),e.color=Rh(e.color)}}}},{key:"parseOptions",value:function(e,i){var n=arguments.length>2&&void 0!==arguments[2]&&arguments[2],o=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},r=arguments.length>4?arguments[4]:void 0,s=["color","fixed","shadow"];if(Oh(s,e,i,n),t.checkMass(i),void 0!==e.opacity&&(t.checkOpacity(e.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+e.opacity),e.opacity=void 0)),void 0!==i.opacity&&(t.checkOpacity(i.opacity)||(console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+i.opacity),i.opacity=void 0)),i.shapeProperties&&!t.checkCoordinateOrigin(i.shapeProperties.coordinateOrigin)&&console.error("Invalid option for node coordinateOrigin, found: "+i.shapeProperties.coordinateOrigin),$h(e,i,"shadow",o),void 0!==i.color&&null!==i.color){var a=Rh(i.color);_h(e.color,a)}else!0===n&&null===i.color&&(e.color=Kh(o.color));void 0!==i.fixed&&null!==i.fixed&&("boolean"==typeof i.fixed?(e.fixed.x=i.fixed,e.fixed.y=i.fixed):(void 0!==i.fixed.x&&"boolean"==typeof i.fixed.x&&(e.fixed.x=i.fixed.x),void 0!==i.fixed.y&&"boolean"==typeof i.fixed.y&&(e.fixed.y=i.fixed.y))),!0===n&&null===i.font&&(e.font=Kh(o.font)),t.updateGroupOptions(e,i,r),void 0!==i.scaling&&$h(e.scaling,i.scaling,"label",o.scaling)}},{key:"checkMass",value:function(t,e){if(void 0!==t.mass&&t.mass<=0){var i="";void 0!==e&&(i=" in node id: "+e),console.error("%cNegative or zero mass disallowed"+i+", setting mass to 1.",cl),t.mass=1}}}]),t}();function uf(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return ff(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return ff(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function ff(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var pf=function(){function t(e,i,n,o){var r,s=this;if(Nn(this,t),this.body=e,this.images=i,this.groups=n,this.layoutEngine=o,this.body.functions.createNode=Vt(r=this.create).call(r,this),this.nodesListeners={add:function(t,e){s.add(e.items)},update:function(t,e){s.update(e.items,e.data,e.oldData)},remove:function(t,e){s.remove(e.items)}},this.defaultOptions={borderWidth:1,borderWidthSelected:void 0,brokenImage:void 0,color:{border:"#2B7CE9",background:"#97C2FC",highlight:{border:"#2B7CE9",background:"#D2E5FF"},hover:{border:"#2B7CE9",background:"#D2E5FF"}},opacity:void 0,fixed:{x:!1,y:!1},font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:0,strokeColor:"#ffffff",align:"center",vadjust:0,multi:!1,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"monospace",vadjust:2}},group:void 0,hidden:!1,icon:{face:"FontAwesome",code:void 0,size:50,color:"#2B7CE9"},image:void 0,imagePadding:{top:0,right:0,bottom:0,left:0},label:void 0,labelHighlightBold:!0,level:void 0,margin:{top:5,right:5,bottom:5,left:5},mass:1,physics:!0,scaling:{min:10,max:30,label:{enabled:!1,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},shape:"ellipse",shapeProperties:{borderDashes:!1,borderRadius:6,interpolation:!0,useImageSize:!1,useBorderWithImage:!1,coordinateOrigin:"center"},size:25,title:void 0,value:void 0,x:void 0,y:void 0},this.defaultOptions.mass<=0)throw"Internal error: mass in defaultOptions of NodesHandler may not be zero or negative";this.options=Kh(this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("refreshNodes",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.nodesListeners,(function(t,e){i.body.data.nodes&&i.body.data.nodes.off(e,t)})),delete i.body.functions.createNode,delete i.nodesListeners.add,delete i.nodesListeners.update,delete i.nodesListeners.remove,delete i.nodesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){if(cf.parseOptions(this.options,t),void 0!==t.opacity&&(yd(t.opacity)||!wd(t.opacity)||t.opacity<0||t.opacity>1?console.error("Invalid option for node opacity. Value must be between 0 and 1, found: "+t.opacity):this.options.opacity=t.opacity),void 0!==t.shape)for(var e in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&this.body.nodes[e].updateShape();if(void 0!==t.font||void 0!==t.widthConstraint||void 0!==t.heightConstraint)for(var i=0,n=zo(this.body.nodes);i<n.length;i++){var o=n[i];this.body.nodes[o].updateLabelModule(),this.body.nodes[o].needsRefresh()}if(void 0!==t.size)for(var r in this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,r)&&this.body.nodes[r].needsRefresh();void 0===t.hidden&&void 0===t.physics||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.data.nodes;if(nu("id",t))this.body.data.nodes=t;else if(So(t))this.body.data.nodes=new tu,this.body.data.nodes.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.nodes=new tu}if(i&&Dh(this.nodesListeners,(function(t,e){i.off(e,t)})),this.body.nodes={},this.body.data.nodes){var n=this;Dh(this.nodesListeners,(function(t,e){n.body.data.nodes.on(e,t)}));var o=this.body.data.nodes.getIds();this.add(o,!0)}!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=[],o=0;o<t.length;o++){e=t[o];var r=this.body.data.nodes.get(e),s=this.create(r);n.push(s),this.body.nodes[e]=s}this.layoutEngine.positionInitially(n),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t,e,i){for(var n=this.body.nodes,o=!1,r=0;r<t.length;r++){var s=t[r],a=n[s],h=e[r];void 0!==a?a.setOptions(h)&&(o=!0):(o=!0,a=this.create(h),n[s]=a)}o||void 0===i||(o=Od(e).call(e,(function(t,e){var n=i[e];return n&&n.level!==t.level}))),!0===o?this.body.emitter.emit("_dataChanged"):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){for(var e=this.body.nodes,i=0;i<t.length;i++){delete e[t[i]]}this.body.emitter.emit("_dataChanged")}},{key:"create",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:cf;return new e(t,this.body,this.images,this.groups,this.options,this.defaultOptions)}},{key:"refresh",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Dh(this.body.nodes,(function(i,n){var o=t.body.data.nodes.get(n);void 0!==o&&(!0===e&&i.setOptions({x:null,y:null}),i.setOptions({fixed:!1}),i.setOptions(o))}))}},{key:"getPositions",value:function(t){var e={};if(void 0!==t){if(!0===So(t)){for(var i=0;i<t.length;i++)if(void 0!==this.body.nodes[t[i]]){var n=this.body.nodes[t[i]];e[t[i]]={x:Math.round(n.x),y:Math.round(n.y)}}}else if(void 0!==this.body.nodes[t]){var o=this.body.nodes[t];e[t]={x:Math.round(o.x),y:Math.round(o.y)}}}else for(var r=0;r<this.body.nodeIndices.length;r++){var s=this.body.nodes[this.body.nodeIndices[r]];e[this.body.nodeIndices[r]]={x:Math.round(s.x),y:Math.round(s.y)}}return e}},{key:"getPosition",value:function(t){if(null==t)throw new TypeError("No id was specified for getPosition method.");if(null==this.body.nodes[t])throw new ReferenceError("NodeId provided for getPosition does not exist. Provided: ".concat(t));return{x:Math.round(this.body.nodes[t].x),y:Math.round(this.body.nodes[t].y)}}},{key:"storePositions",value:function(){var t,e=[],i=this.body.data.nodes.getDataSet(),n=uf(i.get());try{for(n.s();!(t=n.n()).done;){var o=t.value,r=o.id,s=this.body.nodes[r],a=Math.round(s.x),h=Math.round(s.y);o.x===a&&o.y===h||e.push({id:r,x:a,y:h})}}catch(t){n.e(t)}finally{n.f()}i.update(e)}},{key:"getBoundingBox",value:function(t){if(void 0!==this.body.nodes[t])return this.body.nodes[t].shape.boundingBox}},{key:"getConnectedNodes",value:function(t,e){var i=[];if(void 0!==this.body.nodes[t])for(var n=this.body.nodes[t],o={},r=0;r<n.edges.length;r++){var s=n.edges[r];"to"!==e&&s.toId==n.id?void 0===o[s.fromId]&&(i.push(s.fromId),o[s.fromId]=!0):"from"!==e&&s.fromId==n.id&&void 0===o[s.toId]&&(i.push(s.toId),o[s.toId]=!0)}return i}},{key:"getConnectedEdges",value:function(t){var e=[];if(void 0!==this.body.nodes[t])for(var i=this.body.nodes[t],n=0;n<i.edges.length;n++)e.push(i.edges[n].id);else console.error("NodeId provided for getConnectedEdges does not exist. Provided: ",t);return e}},{key:"moveNode",value:function(t,e,i){var n=this;void 0!==this.body.nodes[t]?(this.body.nodes[t].x=Number(e),this.body.nodes[t].y=Number(i),rs((function(){n.body.emitter.emit("startSimulation")}),0)):console.error("Node id supplied to moveNode does not exist. 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i,n,o=0,r=0,s=arguments.length,a=0;r<s;)a<(i=wf(arguments[r++]))?(o=o*(n=a/i)*n+1,a=i):o+=i>0?(n=i/a)*n:i;return a===1/0?1/0:a*kf(o)}});var xf=k.Math.hypot;function Ef(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Of=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"transform",value:function(t,e){So(t)||(t=[t]);for(var i=e.point.x,n=e.point.y,o=e.angle,r=e.length,s=0;s<t.length;++s){var a=t[s],h=a.x*Math.cos(o)-a.y*Math.sin(o),l=a.x*Math.sin(o)+a.y*Math.cos(o);a.x=i+r*h,a.y=n+r*l}}},{key:"drawPath",value:function(t,e){t.beginPath(),t.moveTo(e[0].x,e[0].y);for(var i=1;i<e.length;++i)t.lineTo(e[i].x,e[i].y);t.closePath()}}]),t}(),Cf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){if(e.image){t.save(),t.translate(e.point.x,e.point.y),t.rotate(Math.PI/2+e.angle);var i=null!=e.imageWidth?e.imageWidth:e.image.width,n=null!=e.imageHeight?e.imageHeight:e.image.height;e.image.drawImageAtPosition(t,1,-i/2,0,i,n),t.restore()}return!1}}]),i}(Of),Sf=function(t){Ad(i,t);var e=Ef(i);function i(){return Nn(this,i),e.apply(this,arguments)}return Fn(i,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-1,y:.3},{x:-.9,y:0},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),i}(Of),Tf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:0},{x:0,y:.3},{x:-.4,y:0},{x:0,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Mf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle-n/2,r=e.angle+n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Pf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.3,y:0};Of.transform(i,e),t.strokeStyle=t.fillStyle,t.fillStyle="rgba(0, 0, 0, 0)";var n=Math.PI,o=e.angle+n/2,r=e.angle+3*n/2;return t.beginPath(),t.arc(i.x,i.y,.4*e.length,o,r,!1),t.stroke(),!0}}]),t}(),Df=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:.02,y:0},{x:-1,y:.3},{x:-1,y:-.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),If=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-1,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Bf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i={x:-.4,y:0};return Of.transform(i,e),Ut(t,i.x,i.y,.4*e.length),!0}}]),t}(),zf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.5},{x:0,y:-.5},{x:-.15,y:-.5},{x:-.15,y:.5}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Nf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:.3},{x:0,y:-.3},{x:-.6,y:-.3},{x:-.6,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Af=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:0,y:0},{x:-.5,y:-.3},{x:-1,y:0},{x:-.5,y:.3}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),Ff=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i=[{x:-1,y:.3},{x:-.5,y:0},{x:-1,y:-.3},{x:0,y:0}];return Of.transform(i,e),Of.drawPath(t,i),!0}}]),t}(),jf=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"draw",value:function(t,e){var i;switch(e.type&&(i=e.type.toLowerCase()),i){case"image":return Cf.draw(t,e);case"circle":return Bf.draw(t,e);case"box":return Nf.draw(t,e);case"crow":return Tf.draw(t,e);case"curve":return Mf.draw(t,e);case"diamond":return Af.draw(t,e);case"inv_curve":return Pf.draw(t,e);case"triangle":return Df.draw(t,e);case"inv_triangle":return If.draw(t,e);case"bar":return zf.draw(t,e);case"vee":return Ff.draw(t,e);case"arrow":default:return Sf.draw(t,e)}}}]),t}();function Rf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function Lf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Rf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Rf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}var Hf=function(){function t(e,i,n){Nn(this,t),this._body=i,this._labelModule=n,this.color={},this.colorDirty=!0,this.hoverWidth=1.5,this.selectionWidth=2,this.setOptions(e),this.fromPoint=this.from,this.toPoint=this.to}return Fn(t,[{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to]}},{key:"cleanup",value:function(){return!1}},{key:"setOptions",value:function(t){this.options=t,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.id=this.options.id}},{key:"drawLine",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]?arguments[4]:this.getViaNode();t.strokeStyle=this.getColor(t,e),t.lineWidth=e.width,!1!==e.dashes?this._drawDashedLine(t,e,o):this._drawLine(t,e,o)}},{key:"_drawLine",value:function(t,e,i,n,o){if(this.from!=this.to)this._line(t,e,i,n,o);else{var r=this._getCircleData(t),s=uo(r,3),a=s[0],h=s[1],l=s[2];this._circle(t,e,a,h,l)}}},{key:"_drawDashedLine",value:function(t,e,i,n,o){t.lineCap="round";var r=So(e.dashes)?e.dashes:[5,5];if(void 0!==t.setLineDash){if(t.save(),t.setLineDash(r),t.lineDashOffset=0,this.from!=this.to)this._line(t,e,i);else{var s=this._getCircleData(t),a=uo(s,3),h=a[0],l=a[1],d=a[2];this._circle(t,e,h,l,d)}t.setLineDash([0]),t.lineDashOffset=0,t.restore()}else{if(this.from!=this.to)Kt(t,this.from.x,this.from.y,this.to.x,this.to.y,r);else{var c=this._getCircleData(t),u=uo(c,3),f=u[0],p=u[1],v=u[2];this._circle(t,e,f,p,v)}this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}}},{key:"findBorderPosition",value:function(t,e,i){return this.from!=this.to?this._findBorderPosition(t,e,i):this._findBorderPositionCircle(t,e,i)}},{key:"findBorderPositions",value:function(t){if(this.from!=this.to)return{from:this._findBorderPosition(this.from,t),to:this._findBorderPosition(this.to,t)};var e,i=Oo(e=this._getCircleData(t)).call(e,0,2),n=uo(i,2),o=n[0],r=n[1];return{from:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.25,high:.6,direction:-1}),to:this._findBorderPositionCircle(this.from,t,{x:o,y:r,low:.6,high:.8,direction:1})}}},{key:"_getCircleData",value:function(t){var e=this.options.selfReference.size;void 0!==t&&void 0===this.from.shape.width&&this.from.shape.resize(t);var i=gu(t,this.options.selfReference.angle,e,this.from);return[i.x,i.y,e]}},{key:"_pointOnCircle",value:function(t,e,i,n){var o=2*n*Math.PI;return{x:t+i*Math.cos(o),y:e-i*Math.sin(o)}}},{key:"_findBorderPositionCircle",value:function(t,e,i){var n,o=i.x,r=i.y,s=i.low,a=i.high,h=i.direction,l=this.options.selfReference.size,d=.5*(s+a),c=0;!0===this.options.arrowStrikethrough&&(-1===h?c=this.options.endPointOffset.from:1===h&&(c=this.options.endPointOffset.to));var u=0;do{d=.5*(s+a),n=this._pointOnCircle(o,r,l,d);var f=Math.atan2(t.y-n.y,t.x-n.x),p=t.distanceToBorder(e,f)+c-Math.sqrt(Math.pow(n.x-t.x,2)+Math.pow(n.y-t.y,2));if(Math.abs(p)<.05)break;p>0?h>0?s=d:a=d:h>0?a=d:s=d,++u}while(s<=a&&u<10);return Lf(Lf({},n),{},{t:d})}},{key:"getLineWidth",value:function(t,e){return!0===t?Math.max(this.selectionWidth,.3/this._body.view.scale):!0===e?Math.max(this.hoverWidth,.3/this._body.view.scale):Math.max(this.options.width,.3/this._body.view.scale)}},{key:"getColor",value:function(t,e){if(!1!==e.inheritsColor){if("both"===e.inheritsColor&&this.from.id!==this.to.id){var i=t.createLinearGradient(this.from.x,this.from.y,this.to.x,this.to.y),n=this.from.options.color.highlight.border,o=this.to.options.color.highlight.border;return!1===this.from.selected&&!1===this.to.selected?(n=Fh(this.from.options.color.border,e.opacity),o=Fh(this.to.options.color.border,e.opacity)):!0===this.from.selected&&!1===this.to.selected?o=this.to.options.color.border:!1===this.from.selected&&!0===this.to.selected&&(n=this.from.options.color.border),i.addColorStop(0,n),i.addColorStop(1,o),i}return"to"===e.inheritsColor?Fh(this.to.options.color.border,e.opacity):Fh(this.from.options.color.border,e.opacity)}return Fh(e.color,e.opacity)}},{key:"_circle",value:function(t,e,i,n,o){this.enableShadow(t,e);var r=0,s=2*Math.PI;if(!this.options.selfReference.renderBehindTheNode){var a=this.options.selfReference.angle,h=this.options.selfReference.angle+Math.PI,l=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:-1}),d=this._findBorderPositionCircle(this.from,t,{x:i,y:n,low:a,high:h,direction:1});r=Math.atan2(l.y-n,l.x-i),s=Math.atan2(d.y-n,d.x-i)}t.beginPath(),t.arc(i,n,o,r,s,!1),t.stroke(),this.disableShadow(t,e)}},{key:"getDistanceToEdge",value:function(t,e,i,n,o,r){if(this.from!=this.to)return this._getDistanceToEdge(t,e,i,n,o,r);var s=this._getCircleData(void 0),a=uo(s,3),h=a[0],l=a[1],d=a[2],c=h-o,u=l-r;return Math.abs(Math.sqrt(c*c+u*u)-d)}},{key:"_getDistanceToLine",value:function(t,e,i,n,o,r){var s=i-t,a=n-e,h=((o-t)*s+(r-e)*a)/(s*s+a*a);h>1?h=1:h<0&&(h=0);var l=t+h*s-o,d=e+h*a-r;return Math.sqrt(l*l+d*d)}},{key:"getArrowData",value:function(t,e,i,n,o,r){var s,a,h,l,d,c,u,f=r.width;"from"===e?(h=this.from,l=this.to,d=r.fromArrowScale<0,c=Math.abs(r.fromArrowScale),u=r.fromArrowType):"to"===e?(h=this.to,l=this.from,d=r.toArrowScale<0,c=Math.abs(r.toArrowScale),u=r.toArrowType):(h=this.to,l=this.from,d=r.middleArrowScale<0,c=Math.abs(r.middleArrowScale),u=r.middleArrowType);var p=15*c+3*f;if(h!=l){var v=p/xf(h.x-l.x,h.y-l.y);if("middle"!==e)if(!0===this.options.smooth.enabled){var g=this._findBorderPosition(h,t,{via:i}),y=this.getPoint(g.t+v*("from"===e?1:-1),i);s=Math.atan2(g.y-y.y,g.x-y.x),a=g}else s=Math.atan2(h.y-l.y,h.x-l.x),a=this._findBorderPosition(h,t);else{var m=(d?-v:v)/2,b=this.getPoint(.5+m,i),w=this.getPoint(.5-m,i);s=Math.atan2(b.y-w.y,b.x-w.x),a=this.getPoint(.5,i)}}else{var k=this._getCircleData(t),_=uo(k,3),x=_[0],E=_[1],O=_[2];if("from"===e){var C=this.options.selfReference.angle,S=this.options.selfReference.angle+Math.PI,T=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:C,high:S,direction:-1});s=-2*T.t*Math.PI+1.5*Math.PI+.1*Math.PI,a=T}else if("to"===e){var M=this.options.selfReference.angle,P=this.options.selfReference.angle+Math.PI,D=this._findBorderPositionCircle(this.from,t,{x:x,y:E,low:M,high:P,direction:1});s=-2*D.t*Math.PI+1.5*Math.PI-1.1*Math.PI,a=D}else{var I=this.options.selfReference.angle/(2*Math.PI);a=this._pointOnCircle(x,E,O,I),s=-2*I*Math.PI+1.5*Math.PI+.1*Math.PI}}return{point:a,core:{x:a.x-.9*p*Math.cos(s),y:a.y-.9*p*Math.sin(s)},angle:s,length:p,type:u}}},{key:"drawArrowHead",value:function(t,e,i,n,o){t.strokeStyle=this.getColor(t,e),t.fillStyle=t.strokeStyle,t.lineWidth=e.width,jf.draw(t,o)&&(this.enableShadow(t,e),hs(t).call(t),this.disableShadow(t,e))}},{key:"enableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor=e.shadowColor,t.shadowBlur=e.shadowSize,t.shadowOffsetX=e.shadowX,t.shadowOffsetY=e.shadowY)}},{key:"disableShadow",value:function(t,e){!0===e.shadow&&(t.shadowColor="rgba(0,0,0,0)",t.shadowBlur=0,t.shadowOffsetX=0,t.shadowOffsetY=0)}},{key:"drawBackground",value:function(t,e){if(!1!==e.background){var i={strokeStyle:t.strokeStyle,lineWidth:t.lineWidth,dashes:t.dashes};t.strokeStyle=e.backgroundColor,t.lineWidth=e.backgroundSize,this.setStrokeDashed(t,e.backgroundDashes),t.stroke(),t.strokeStyle=i.strokeStyle,t.lineWidth=i.lineWidth,t.dashes=i.dashes,this.setStrokeDashed(t,e.dashes)}}},{key:"setStrokeDashed",value:function(t,e){if(!1!==e)if(void 0!==t.setLineDash){var i=So(e)?e:[5,5];t.setLineDash(i)}else console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.");else void 0!==t.setLineDash?t.setLineDash([]):console.warn("setLineDash is not supported in this browser. The dashed stroke cannot be used.")}}]),t}();function Wf(t,e){var i=zo(t);if(On){var n=On(t);e&&(n=mr(n).call(n,(function(e){return Mn(t,e).enumerable}))),i.push.apply(i,n)}return i}function qf(t){for(var e=1;e<arguments.length;e++){var i,n=null!=arguments[e]?arguments[e]:{};if(e%2)Wo(i=Wf(Object(n),!0)).call(i,(function(e){jn(t,e,n[e])}));else if(Dn)In(t,Dn(n));else{var o;Wo(o=Wf(Object(n))).call(o,(function(e){zn(t,e,Mn(n,e))}))}}return t}function Vf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Uf=function(t){Ad(i,t);var e=Vf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_findBorderPositionBezier",value:function(t,e){var i,n,o=arguments.length>2&&void 0!==arguments[2]?arguments[2]:this._getViaCoordinates(),r=10,s=.2,a=!1,h=1,l=0,d=this.to,c=this.options.endPointOffset?this.options.endPointOffset.to:0;t.id===this.from.id&&(d=this.from,a=!0,c=this.options.endPointOffset?this.options.endPointOffset.from:0),!1===this.options.arrowStrikethrough&&(c=0);var u=0;do{n=.5*(l+h),i=this.getPoint(n,o);var f=Math.atan2(d.y-i.y,d.x-i.x),p=d.distanceToBorder(e,f)+c,v=Math.sqrt(Math.pow(i.x-d.x,2)+Math.pow(i.y-d.y,2)),g=p-v;if(Math.abs(g)<s)break;g<0?!1===a?l=n:h=n:!1===a?h=n:l=n,++u}while(l<=h&&u<r);return qf(qf({},i),{},{t:n})}},{key:"_getDistanceToBezierEdge",value:function(t,e,i,n,o,r,s){var a,h,l,d,c,u=1e9,f=t,p=e;for(h=1;h<10;h++)l=.1*h,d=Math.pow(1-l,2)*t+2*l*(1-l)*s.x+Math.pow(l,2)*i,c=Math.pow(1-l,2)*e+2*l*(1-l)*s.y+Math.pow(l,2)*n,h>0&&(u=(a=this._getDistanceToLine(f,p,d,c,o,r))<u?a:u),f=d,p=c;return u}},{key:"_bezierCurve",value:function(t,e,i,n){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),null!=i&&null!=i.x?null!=n&&null!=n.x?t.bezierCurveTo(i.x,i.y,n.x,n.y,this.toPoint.x,this.toPoint.y):t.quadraticCurveTo(i.x,i.y,this.toPoint.x,this.toPoint.y):t.lineTo(this.toPoint.x,this.toPoint.y),this.drawBackground(t,e),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}}]),i}(Hf);function Yf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Xf=function(t){Ad(i,t);var e=Yf(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o)).via=r.via,r._boundFunction=function(){r.positionBezierNode()},r._body.emitter.on("_repositionBezierNodes",r._boundFunction),r}return Fn(i,[{key:"setOptions",value:function(t){mf(Ld(i.prototype),"setOptions",this).call(this,t);var e=!1;this.options.physics!==t.physics&&(e=!0),this.options=t,this.id=this.options.id,this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],this.setupSupportNode(),this.connect(),!0===e&&(this.via.setOptions({physics:this.options.physics}),this.positionBezierNode())}},{key:"connect",value:function(){this.from=this._body.nodes[this.options.from],this.to=this._body.nodes[this.options.to],void 0===this.from||void 0===this.to||!1===this.options.physics||this.from.id===this.to.id?this.via.setOptions({physics:!1}):this.via.setOptions({physics:!0})}},{key:"cleanup",value:function(){return this._body.emitter.off("_repositionBezierNodes",this._boundFunction),void 0!==this.via&&(delete this._body.nodes[this.via.id],this.via=void 0,!0)}},{key:"setupSupportNode",value:function(){if(void 0===this.via){var t="edgeId:"+this.id,e=this._body.functions.createNode({id:t,shape:"circle",physics:!0,hidden:!0});this._body.nodes[t]=e,this.via=e,this.via.parentEdgeId=this.id,this.positionBezierNode()}}},{key:"positionBezierNode",value:function(){void 0!==this.via&&void 0!==this.from&&void 0!==this.to?(this.via.x=.5*(this.from.x+this.to.x),this.via.y=.5*(this.from.y+this.to.y)):void 0!==this.via&&(this.via.x=0,this.via.y=0)}},{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"_getViaCoordinates",value:function(){return this.via}},{key:"getViaNode",value:function(){return this.via}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.via;if(this.from===this.to){var i=this._getCircleData(),n=uo(i,3),o=n[0],r=n[1],s=n[2],a=2*Math.PI*(1-t);return{x:o+s*Math.sin(a),y:r+s-s*(1-Math.cos(a))}}return{x:Math.pow(1-t,2)*this.fromPoint.x+2*t*(1-t)*e.x+Math.pow(t,2)*this.toPoint.x,y:Math.pow(1-t,2)*this.fromPoint.y+2*t*(1-t)*e.y+Math.pow(t,2)*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e,this.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToBezierEdge(t,e,i,n,o,r,this.via)}}]),i}(Uf);function Gf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Kf=function(t){Ad(i,t);var e=Gf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){this._bezierCurve(t,e,i)}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_getViaCoordinates",value:function(){var t,e,i=this.options.smooth.roundness,n=this.options.smooth.type,o=Math.abs(this.from.x-this.to.x),r=Math.abs(this.from.y-this.to.y);if("discrete"===n||"diagonalCross"===n){var s,a;s=a=o<=r?i*r:i*o,this.from.x>this.to.x&&(s=-s),this.from.y>=this.to.y&&(a=-a);var h=this.from.x+s,l=this.from.y+a;return"discrete"===n&&(o<=r?h=o<i*r?this.from.x:h:l=r<i*o?this.from.y:l),{x:h,y:l}}if("straightCross"===n){var d=(1-i)*o,c=(1-i)*r;return o<=r?(d=0,this.from.y<this.to.y&&(c=-c)):(this.from.x<this.to.x&&(d=-d),c=0),{x:this.to.x+d,y:this.to.y+c}}if("horizontal"===n){var u=(1-i)*o;return this.from.x<this.to.x&&(u=-u),{x:this.to.x+u,y:this.from.y}}if("vertical"===n){var f=(1-i)*r;return this.from.y<this.to.y&&(f=-f),{x:this.from.x,y:this.to.y+f}}if("curvedCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var p=Math.sqrt(o*o+r*r),v=Math.PI,g=(Math.atan2(r,o)+(.5*i+.5)*v)%(2*v);return{x:this.from.x+(.5*i+.5)*p*Math.sin(g),y:this.from.y+(.5*i+.5)*p*Math.cos(g)}}if("curvedCCW"===n){o=this.to.x-this.from.x,r=this.from.y-this.to.y;var y=Math.sqrt(o*o+r*r),m=Math.PI,b=(Math.atan2(r,o)+(.5*-i+.5)*m)%(2*m);return{x:this.from.x+(.5*i+.5)*y*Math.sin(b),y:this.from.y+(.5*i+.5)*y*Math.cos(b)}}t=e=o<=r?i*r:i*o,this.from.x>this.to.x&&(t=-t),this.from.y>=this.to.y&&(e=-e);var w=this.from.x+t,k=this.from.y+e;return o<=r?w=this.from.x<=this.to.x?this.to.x<w?this.to.x:w:this.to.x>w?this.to.x:w:k=this.from.y>=this.to.y?this.to.y>k?this.to.y:k:this.to.y<k?this.to.y:k,{x:w,y:k}}},{key:"_findBorderPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{};return this._findBorderPositionBezier(t,e,i.via)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates();return this._getDistanceToBezierEdge(t,e,i,n,o,r,s)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=t,n=Math.pow(1-i,2)*this.fromPoint.x+2*i*(1-i)*e.x+Math.pow(i,2)*this.toPoint.x,o=Math.pow(1-i,2)*this.fromPoint.y+2*i*(1-i)*e.y+Math.pow(i,2)*this.toPoint.y;return{x:n,y:o}}}]),i}(Uf);function $f(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}function Zf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var Qf=function(t){Ad(i,t);var e=Zf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e,i){var n=i[0],o=i[1];this._bezierCurve(t,e,n,o)}},{key:"_getViaCoordinates",value:function(){var t,e,i,n,o=this.from.x-this.to.x,r=this.from.y-this.to.y,s=this.options.smooth.roundness;return(Math.abs(o)>Math.abs(r)||!0===this.options.smooth.forceDirection||"horizontal"===this.options.smooth.forceDirection)&&"vertical"!==this.options.smooth.forceDirection?(e=this.from.y,n=this.to.y,t=this.from.x-s*o,i=this.to.x+s*o):(e=this.from.y-s*r,n=this.to.y+s*r,t=this.from.x,i=this.to.x),[{x:t,y:e},{x:i,y:n}]}},{key:"getViaNode",value:function(){return this._getViaCoordinates()}},{key:"_findBorderPosition",value:function(t,e){return this._findBorderPositionBezier(t,e)}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){var s=arguments.length>6&&void 0!==arguments[6]?arguments[6]:this._getViaCoordinates(),a=uo(s,2),h=a[0],l=a[1];return this._getDistanceToBezierEdge2(t,e,i,n,o,r,h,l)}},{key:"getPoint",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this._getViaCoordinates(),i=uo(e,2),n=i[0],o=i[1],r=t,s=[Math.pow(1-r,3),3*r*Math.pow(1-r,2),3*Math.pow(r,2)*(1-r),Math.pow(r,3)],a=s[0]*this.fromPoint.x+s[1]*n.x+s[2]*o.x+s[3]*this.toPoint.x,h=s[0]*this.fromPoint.y+s[1]*n.y+s[2]*o.y+s[3]*this.toPoint.y;return{x:a,y:h}}}]),i}(function(t){Ad(i,t);var e=$f(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_getDistanceToBezierEdge2",value:function(t,e,i,n,o,r,s,a){for(var h=1e9,l=t,d=e,c=[0,0,0,0],u=1;u<10;u++){var f=.1*u;c[0]=Math.pow(1-f,3),c[1]=3*f*Math.pow(1-f,2),c[2]=3*Math.pow(f,2)*(1-f),c[3]=Math.pow(f,3);var p=c[0]*t+c[1]*s.x+c[2]*a.x+c[3]*i,v=c[0]*e+c[1]*s.y+c[2]*a.y+c[3]*n;if(u>0){var g=this._getDistanceToLine(l,d,p,v,o,r);h=g<h?g:h}l=p,d=v}return h}}]),i}(Uf));function Jf(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var tp=function(t){Ad(i,t);var e=Jf(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_line",value:function(t,e){t.beginPath(),t.moveTo(this.fromPoint.x,this.fromPoint.y),t.lineTo(this.toPoint.x,this.toPoint.y),this.enableShadow(t,e),t.stroke(),this.disableShadow(t,e)}},{key:"getViaNode",value:function(){}},{key:"getPoint",value:function(t){return{x:(1-t)*this.fromPoint.x+t*this.toPoint.x,y:(1-t)*this.fromPoint.y+t*this.toPoint.y}}},{key:"_findBorderPosition",value:function(t,e){var i=this.to,n=this.from;t.id===this.from.id&&(i=this.from,n=this.to);var o=Math.atan2(i.y-n.y,i.x-n.x),r=i.x-n.x,s=i.y-n.y,a=Math.sqrt(r*r+s*s),h=(a-t.distanceToBorder(e,o))/a;return{x:(1-h)*n.x+h*i.x,y:(1-h)*n.y+h*i.y,t:0}}},{key:"_getDistanceToEdge",value:function(t,e,i,n,o,r){return this._getDistanceToLine(t,e,i,n,o,r)}}]),i}(Hf),ep=function(){function t(e,i,n,o,r){if(Nn(this,t),void 0===i)throw new Error("No body provided");this.options=Kh(o),this.globalOptions=o,this.defaultOptions=r,this.body=i,this.imagelist=n,this.id=void 0,this.fromId=void 0,this.toId=void 0,this.selected=!1,this.hover=!1,this.labelDirty=!0,this.baseWidth=this.options.width,this.baseFontSize=this.options.font.size,this.from=void 0,this.to=void 0,this.edgeType=void 0,this.connected=!1,this.labelModule=new _u(this.body,this.options,!0),this.setOptions(e)}return Fn(t,[{key:"setOptions",value:function(e){if(e){var i=void 0!==e.physics&&this.options.physics!==e.physics||void 0!==e.hidden&&(this.options.hidden||!1)!==(e.hidden||!1)||void 0!==e.from&&this.options.from!==e.from||void 0!==e.to&&this.options.to!==e.to;t.parseOptions(this.options,e,!0,this.globalOptions),void 0!==e.id&&(this.id=e.id),void 0!==e.from&&(this.fromId=e.from),void 0!==e.to&&(this.toId=e.to),void 0!==e.title&&(this.title=e.title),void 0!==e.value&&(e.value=hu(e.value));var n=[e,this.options,this.defaultOptions];return this.chooser=fu("edge",n),this.updateLabelModule(e),i=this.updateEdgeType()||i,this._setInteractionWidths(),this.connect(),i}}},{key:"getFormattingValues",value:function(){var t=!0===this.options.arrows.to||!0===this.options.arrows.to.enabled,e=!0===this.options.arrows.from||!0===this.options.arrows.from.enabled,i=!0===this.options.arrows.middle||!0===this.options.arrows.middle.enabled,n=this.options.color.inherit,o={toArrow:t,toArrowScale:this.options.arrows.to.scaleFactor,toArrowType:this.options.arrows.to.type,toArrowSrc:this.options.arrows.to.src,toArrowImageWidth:this.options.arrows.to.imageWidth,toArrowImageHeight:this.options.arrows.to.imageHeight,middleArrow:i,middleArrowScale:this.options.arrows.middle.scaleFactor,middleArrowType:this.options.arrows.middle.type,middleArrowSrc:this.options.arrows.middle.src,middleArrowImageWidth:this.options.arrows.middle.imageWidth,middleArrowImageHeight:this.options.arrows.middle.imageHeight,fromArrow:e,fromArrowScale:this.options.arrows.from.scaleFactor,fromArrowType:this.options.arrows.from.type,fromArrowSrc:this.options.arrows.from.src,fromArrowImageWidth:this.options.arrows.from.imageWidth,fromArrowImageHeight:this.options.arrows.from.imageHeight,arrowStrikethrough:this.options.arrowStrikethrough,color:n?void 0:this.options.color.color,inheritsColor:n,opacity:this.options.color.opacity,hidden:this.options.hidden,length:this.options.length,shadow:this.options.shadow.enabled,shadowColor:this.options.shadow.color,shadowSize:this.options.shadow.size,shadowX:this.options.shadow.x,shadowY:this.options.shadow.y,dashes:this.options.dashes,width:this.options.width,background:this.options.background.enabled,backgroundColor:this.options.background.color,backgroundSize:this.options.background.size,backgroundDashes:this.options.background.dashes};if(this.selected||this.hover)if(!0===this.chooser){if(this.selected){var r=this.options.selectionWidth;"function"==typeof r?o.width=r(o.width):"number"==typeof r&&(o.width+=r),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.highlight,o.shadow=this.options.shadow.enabled}else if(this.hover){var s=this.options.hoverWidth;"function"==typeof s?o.width=s(o.width):"number"==typeof s&&(o.width+=s),o.width=Math.max(o.width,.3/this.body.view.scale),o.color=this.options.color.hover,o.shadow=this.options.shadow.enabled}}else"function"==typeof this.chooser&&(this.chooser(o,this.options.id,this.selected,this.hover),void 0!==o.color&&(o.inheritsColor=!1),!1===o.shadow&&(o.shadowColor===this.options.shadow.color&&o.shadowSize===this.options.shadow.size&&o.shadowX===this.options.shadow.x&&o.shadowY===this.options.shadow.y||(o.shadow=!0)));else o.shadow=this.options.shadow.enabled,o.width=Math.max(o.width,.3/this.body.view.scale);return o}},{key:"updateLabelModule",value:function(t){var e=[t,this.options,this.globalOptions,this.defaultOptions];this.labelModule.update(this.options,e),void 0!==this.labelModule.baseSize&&(this.baseFontSize=this.labelModule.baseSize)}},{key:"updateEdgeType",value:function(){var t=this.options.smooth,e=!1,i=!0;return void 0!==this.edgeType&&((this.edgeType instanceof Xf&&!0===t.enabled&&"dynamic"===t.type||this.edgeType instanceof Qf&&!0===t.enabled&&"cubicBezier"===t.type||this.edgeType instanceof Kf&&!0===t.enabled&&"dynamic"!==t.type&&"cubicBezier"!==t.type||this.edgeType instanceof tp&&!1===t.type.enabled)&&(i=!1),!0===i&&(e=this.cleanup())),!0===i?!0===t.enabled?"dynamic"===t.type?(e=!0,this.edgeType=new Xf(this.options,this.body,this.labelModule)):"cubicBezier"===t.type?this.edgeType=new Qf(this.options,this.body,this.labelModule):this.edgeType=new Kf(this.options,this.body,this.labelModule):this.edgeType=new tp(this.options,this.body,this.labelModule):this.edgeType.setOptions(this.options),e}},{key:"connect",value:function(){this.disconnect(),this.from=this.body.nodes[this.fromId]||void 0,this.to=this.body.nodes[this.toId]||void 0,this.connected=void 0!==this.from&&void 0!==this.to,!0===this.connected?(this.from.attachEdge(this),this.to.attachEdge(this)):(this.from&&this.from.detachEdge(this),this.to&&this.to.detachEdge(this)),this.edgeType.connect()}},{key:"disconnect",value:function(){this.from&&(this.from.detachEdge(this),this.from=void 0),this.to&&(this.to.detachEdge(this),this.to=void 0),this.connected=!1}},{key:"getTitle",value:function(){return this.title}},{key:"isSelected",value:function(){return this.selected}},{key:"getValue",value:function(){return this.options.value}},{key:"setValueRange",value:function(t,e,i){if(void 0!==this.options.value){var n=this.options.scaling.customScalingFunction(t,e,i,this.options.value),o=this.options.scaling.max-this.options.scaling.min;if(!0===this.options.scaling.label.enabled){var r=this.options.scaling.label.max-this.options.scaling.label.min;this.options.font.size=this.options.scaling.label.min+n*r}this.options.width=this.options.scaling.min+n*o}else this.options.width=this.baseWidth,this.options.font.size=this.baseFontSize;this._setInteractionWidths(),this.updateLabelModule()}},{key:"_setInteractionWidths",value:function(){"function"==typeof this.options.hoverWidth?this.edgeType.hoverWidth=this.options.hoverWidth(this.options.width):this.edgeType.hoverWidth=this.options.hoverWidth+this.options.width,"function"==typeof this.options.selectionWidth?this.edgeType.selectionWidth=this.options.selectionWidth(this.options.width):this.edgeType.selectionWidth=this.options.selectionWidth+this.options.width}},{key:"draw",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode();this.edgeType.drawLine(t,e,this.selected,this.hover,i),this.drawLabel(t,i)}}},{key:"drawArrows",value:function(t){var e=this.getFormattingValues();if(!e.hidden){var i=this.edgeType.getViaNode(),n={};this.edgeType.fromPoint=this.edgeType.from,this.edgeType.toPoint=this.edgeType.to,e.fromArrow&&(n.from=this.edgeType.getArrowData(t,"from",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.fromPoint=n.from.core),e.fromArrowSrc&&(n.from.image=this.imagelist.load(e.fromArrowSrc)),e.fromArrowImageWidth&&(n.from.imageWidth=e.fromArrowImageWidth),e.fromArrowImageHeight&&(n.from.imageHeight=e.fromArrowImageHeight)),e.toArrow&&(n.to=this.edgeType.getArrowData(t,"to",i,this.selected,this.hover,e),!1===e.arrowStrikethrough&&(this.edgeType.toPoint=n.to.core),e.toArrowSrc&&(n.to.image=this.imagelist.load(e.toArrowSrc)),e.toArrowImageWidth&&(n.to.imageWidth=e.toArrowImageWidth),e.toArrowImageHeight&&(n.to.imageHeight=e.toArrowImageHeight)),e.middleArrow&&(n.middle=this.edgeType.getArrowData(t,"middle",i,this.selected,this.hover,e),e.middleArrowSrc&&(n.middle.image=this.imagelist.load(e.middleArrowSrc)),e.middleArrowImageWidth&&(n.middle.imageWidth=e.middleArrowImageWidth),e.middleArrowImageHeight&&(n.middle.imageHeight=e.middleArrowImageHeight)),e.fromArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.from),e.middleArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.middle),e.toArrow&&this.edgeType.drawArrowHead(t,e,this.selected,this.hover,n.to)}}},{key:"drawLabel",value:function(t,e){if(void 0!==this.options.label){var i,n=this.from,o=this.to;if(this.labelModule.differentState(this.selected,this.hover)&&this.labelModule.getTextSize(t,this.selected,this.hover),n.id!=o.id){this.labelModule.pointToSelf=!1,i=this.edgeType.getPoint(.5,e),t.save();var r=this._getRotation(t);0!=r.angle&&(t.translate(r.x,r.y),t.rotate(r.angle)),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover),t.restore()}else{this.labelModule.pointToSelf=!0;var s=gu(t,this.options.selfReference.angle,this.options.selfReference.size,n);i=this._pointOnCircle(s.x,s.y,this.options.selfReference.size,this.options.selfReference.angle),this.labelModule.draw(t,i.x,i.y,this.selected,this.hover)}}}},{key:"getItemsOnPoint",value:function(t){var e=[];if(this.labelModule.visible()){var i=this._getRotation();pu(this.labelModule.getSize(),t,i)&&e.push({edgeId:this.id,labelId:0})}var n={left:t.x,top:t.y};return this.isOverlappingWith(n)&&e.push({edgeId:this.id}),e}},{key:"isOverlappingWith",value:function(t){if(this.connected){var e=this.from.x,i=this.from.y,n=this.to.x,o=this.to.y,r=t.left,s=t.top;return this.edgeType.getDistanceToEdge(e,i,n,o,r,s)<10}return!1}},{key:"_getRotation",value:function(t){var e=this.edgeType.getViaNode(),i=this.edgeType.getPoint(.5,e);void 0!==t&&this.labelModule.calculateLabelSize(t,this.selected,this.hover,i.x,i.y);var n={x:i.x,y:this.labelModule.size.yLine,angle:0};if(!this.labelModule.visible())return n;if("horizontal"===this.options.font.align)return n;var o=this.from.y-this.to.y,r=this.from.x-this.to.x,s=Math.atan2(o,r);return(s<-1&&r<0||s>0&&r<0)&&(s+=Math.PI),n.angle=s,n}},{key:"_pointOnCircle",value:function(t,e,i,n){return{x:t+i*Math.cos(n),y:e-i*Math.sin(n)}}},{key:"select",value:function(){this.selected=!0}},{key:"unselect",value:function(){this.selected=!1}},{key:"cleanup",value:function(){return this.edgeType.cleanup()}},{key:"remove",value:function(){this.cleanup(),this.disconnect(),delete this.body.edges[this.id]}},{key:"endPointsValid",value:function(){return void 0!==this.body.nodes[this.fromId]&&void 0!==this.body.nodes[this.toId]}}],[{key:"parseOptions",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:{},o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=["endPointOffset","arrowStrikethrough","id","from","hidden","hoverWidth","labelHighlightBold","length","line","opacity","physics","scaling","selectionWidth","selfReferenceSize","selfReference","to","title","value","width","font","chosen","widthConstraint"];if(Eh(r,t,e,i),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.from&&(wd(e.endPointOffset.from)?t.endPointOffset.from=e.endPointOffset.from:(t.endPointOffset.from=void 0!==n.endPointOffset.from?n.endPointOffset.from:0,console.error("endPointOffset.from is not a valid number"))),void 0!==e.endPointOffset&&void 0!==e.endPointOffset.to&&(wd(e.endPointOffset.to)?t.endPointOffset.to=e.endPointOffset.to:(t.endPointOffset.to=void 0!==n.endPointOffset.to?n.endPointOffset.to:0,console.error("endPointOffset.to is not a valid number"))),vu(e.label)?t.label=e.label:vu(t.label)||(t.label=void 0),$h(t,e,"smooth",n),$h(t,e,"shadow",n),$h(t,e,"background",n),void 0!==e.dashes&&null!==e.dashes?t.dashes=e.dashes:!0===i&&null===e.dashes&&(t.dashes=Gr(n.dashes)),void 0!==e.scaling&&null!==e.scaling?(void 0!==e.scaling.min&&(t.scaling.min=e.scaling.min),void 0!==e.scaling.max&&(t.scaling.max=e.scaling.max),$h(t.scaling,e.scaling,"label",n.scaling)):!0===i&&null===e.scaling&&(t.scaling=Gr(n.scaling)),void 0!==e.arrows&&null!==e.arrows)if("string"==typeof e.arrows){var s=e.arrows.toLowerCase();t.arrows.to.enabled=-1!=Hr(s).call(s,"to"),t.arrows.middle.enabled=-1!=Hr(s).call(s,"middle"),t.arrows.from.enabled=-1!=Hr(s).call(s,"from")}else{if("object"!==go(e.arrows))throw new Error("The arrow newOptions can only be an object or a string. Refer to the documentation. You used:"+es(e.arrows));$h(t.arrows,e.arrows,"to",n.arrows),$h(t.arrows,e.arrows,"middle",n.arrows),$h(t.arrows,e.arrows,"from",n.arrows)}else!0===i&&null===e.arrows&&(t.arrows=Gr(n.arrows));if(void 0!==e.color&&null!==e.color){var a=bh(e.color)?{color:e.color,highlight:e.color,hover:e.color,inherit:!1,opacity:1}:e.color,h=t.color;if(o)Ch(h,n.color,!1,i);else for(var l in h)Object.prototype.hasOwnProperty.call(h,l)&&delete h[l];if(bh(h))h.color=h,h.highlight=h,h.hover=h,h.inherit=!1,void 0===a.opacity&&(h.opacity=1);else{var d=!1;void 0!==a.color&&(h.color=a.color,d=!0),void 0!==a.highlight&&(h.highlight=a.highlight,d=!0),void 0!==a.hover&&(h.hover=a.hover,d=!0),void 0!==a.inherit&&(h.inherit=a.inherit),void 0!==a.opacity&&(h.opacity=Math.min(1,Math.max(0,a.opacity))),!0===d?h.inherit=!1:void 0===h.inherit&&(h.inherit="from")}}else!0===i&&null===e.color&&(t.color=Kh(n.color));!0===i&&null===e.font&&(t.font=Kh(n.font)),Object.prototype.hasOwnProperty.call(e,"selfReferenceSize")&&(console.warn("The selfReferenceSize property has been deprecated. Please use selfReference property instead. The selfReference can be set like thise selfReference:{size:30, angle:Math.PI / 4}"),t.selfReference.size=e.selfReferenceSize)}}]),t}(),ip=function(){function t(e,i,n){var o,r=this;Nn(this,t),this.body=e,this.images=i,this.groups=n,this.body.functions.createEdge=Vt(o=this.create).call(o,this),this.edgesListeners={add:function(t,e){r.add(e.items)},update:function(t,e){r.update(e.items)},remove:function(t,e){r.remove(e.items)}},this.options={},this.defaultOptions={arrows:{to:{enabled:!1,scaleFactor:1,type:"arrow"},middle:{enabled:!1,scaleFactor:1,type:"arrow"},from:{enabled:!1,scaleFactor:1,type:"arrow"}},endPointOffset:{from:0,to:0},arrowStrikethrough:!0,color:{color:"#848484",highlight:"#848484",hover:"#848484",inherit:"from",opacity:1},dashes:!1,font:{color:"#343434",size:14,face:"arial",background:"none",strokeWidth:2,strokeColor:"#ffffff",align:"horizontal",multi:!1,vadjust:0,bold:{mod:"bold"},boldital:{mod:"bold italic"},ital:{mod:"italic"},mono:{mod:"",size:15,face:"courier new",vadjust:2}},hidden:!1,hoverWidth:1.5,label:void 0,labelHighlightBold:!0,length:void 0,physics:!0,scaling:{min:1,max:15,label:{enabled:!0,min:14,max:30,maxVisible:30,drawThreshold:5},customScalingFunction:function(t,e,i,n){if(e===t)return.5;var o=1/(e-t);return Math.max(0,(n-t)*o)}},selectionWidth:1.5,selfReference:{size:20,angle:Math.PI/4,renderBehindTheNode:!0},shadow:{enabled:!1,color:"rgba(0,0,0,0.5)",size:10,x:5,y:5},background:{enabled:!1,color:"rgba(111,111,111,1)",size:10,dashes:!1},smooth:{enabled:!0,type:"dynamic",forceDirection:"none",roundness:.5},title:void 0,width:1,value:void 0},Ch(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e,i=this;this.body.emitter.on("_forceDisableDynamicCurves",(function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];"dynamic"===t&&(t="continuous");var n=!1;for(var o in i.body.edges)if(Object.prototype.hasOwnProperty.call(i.body.edges,o)){var r=i.body.edges[o],s=i.body.data.edges.get(o);if(null!=s){var a=s.smooth;void 0!==a&&!0===a.enabled&&"dynamic"===a.type&&(void 0===t?r.setOptions({smooth:!1}):r.setOptions({smooth:{type:t}}),n=!0)}}!0===e&&!0===n&&i.body.emitter.emit("_dataChanged")})),this.body.emitter.on("_dataUpdated",(function(){i.reconnectEdges()})),this.body.emitter.on("refreshEdges",Vt(t=this.refresh).call(t,this)),this.body.emitter.on("refresh",Vt(e=this.refresh).call(e,this)),this.body.emitter.on("destroy",(function(){Dh(i.edgesListeners,(function(t,e){i.body.data.edges&&i.body.data.edges.off(e,t)})),delete i.body.functions.createEdge,delete i.edgesListeners.add,delete i.edgesListeners.update,delete i.edgesListeners.remove,delete i.edgesListeners}))}},{key:"setOptions",value:function(t){if(void 0!==t){ep.parseOptions(this.options,t,!0,this.defaultOptions,!0);var e=!1;if(void 0!==t.smooth)for(var i in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,i)&&(e=this.body.edges[i].updateEdgeType()||e);if(void 0!==t.font)for(var n in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,n)&&this.body.edges[n].updateLabelModule();void 0===t.hidden&&void 0===t.physics&&!0!==e||this.body.emitter.emit("_dataChanged")}}},{key:"setData",value:function(t){var e=this,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1],n=this.body.data.edges;if(nu("id",t))this.body.data.edges=t;else if(So(t))this.body.data.edges=new tu,this.body.data.edges.add(t);else{if(t)throw new TypeError("Array or DataSet expected");this.body.data.edges=new tu}if(n&&Dh(this.edgesListeners,(function(t,e){n.off(e,t)})),this.body.edges={},this.body.data.edges){Dh(this.edgesListeners,(function(t,i){e.body.data.edges.on(i,t)}));var o=this.body.data.edges.getIds();this.add(o,!0)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===i&&this.body.emitter.emit("_dataChanged")}},{key:"add",value:function(t){for(var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1],i=this.body.edges,n=this.body.data.edges,o=0;o<t.length;o++){var r=t[o],s=i[r];s&&s.disconnect();var a=n.get(r,{showInternalIds:!0});i[r]=this.create(a)}this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),!1===e&&this.body.emitter.emit("_dataChanged")}},{key:"update",value:function(t){for(var e=this.body.edges,i=this.body.data.edges,n=!1,o=0;o<t.length;o++){var r=t[o],s=i.get(r),a=e[r];void 0!==a?(a.disconnect(),n=a.setOptions(s)||n,a.connect()):(this.body.edges[r]=this.create(s),n=!0)}!0===n?(this.body.emitter.emit("_adjustEdgesForHierarchicalLayout"),this.body.emitter.emit("_dataChanged")):this.body.emitter.emit("_dataUpdated")}},{key:"remove",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(0!==t.length){var i=this.body.edges;Dh(t,(function(t){var e=i[t];void 0!==e&&e.remove()})),e&&this.body.emitter.emit("_dataChanged")}}},{key:"refresh",value:function(){var t=this;Dh(this.body.edges,(function(e,i){var n=t.body.data.edges.get(i);void 0!==n&&e.setOptions(n)}))}},{key:"create",value:function(t){return new ep(t,this.body,this.images,this.options,this.defaultOptions)}},{key:"reconnectEdges",value:function(){var t,e=this.body.nodes,i=this.body.edges;for(t in e)Object.prototype.hasOwnProperty.call(e,t)&&(e[t].edges=[]);for(t in i)if(Object.prototype.hasOwnProperty.call(i,t)){var n=i[t];n.from=null,n.to=null,n.connect()}}},{key:"getConnectedNodes",value:function(t){var e=[];if(void 0!==this.body.edges[t]){var i=this.body.edges[t];void 0!==i.fromId&&e.push(i.fromId),void 0!==i.toId&&e.push(i.toId)}return e}},{key:"_updateState",value:function(){this._addMissingEdges(),this._removeInvalidEdges()}},{key:"_removeInvalidEdges",value:function(){var t=this,e=[];Dh(this.body.edges,(function(i,n){var o=t.body.nodes[i.toId],r=t.body.nodes[i.fromId];void 0!==o&&!0===o.isCluster||void 0!==r&&!0===r.isCluster||void 0!==o&&void 0!==r||e.push(n)})),this.remove(e,!1)}},{key:"_addMissingEdges",value:function(){var t=this.body.data.edges;if(null!=t){var e=this.body.edges,i=[];Wo(t).call(t,(function(t,n){void 0===e[n]&&i.push(n)})),this.add(i,!0)}}}]),t}(),np=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.barnesHutTree,this.setOptions(n),this._rng=ah("BARNES HUT SOLVER")}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.thetaInversed=1/this.options.theta,this.overlapAvoidanceFactor=1-Math.max(0,Math.min(1,this.options.avoidOverlap))}},{key:"solve",value:function(){if(0!==this.options.gravitationalConstant&&this.physicsBody.physicsNodeIndices.length>0){var t,e=this.body.nodes,i=this.physicsBody.physicsNodeIndices,n=i.length,o=this._formBarnesHutTree(e,i);this.barnesHutTree=o;for(var r=0;r<n;r++)(t=e[i[r]]).options.mass>0&&this._getForceContributions(o.root,t)}}},{key:"_getForceContributions",value:function(t,e){this._getForceContribution(t.children.NW,e),this._getForceContribution(t.children.NE,e),this._getForceContribution(t.children.SW,e),this._getForceContribution(t.children.SE,e)}},{key:"_getForceContribution",value:function(t,e){if(t.childrenCount>0){var i=t.centerOfMass.x-e.x,n=t.centerOfMass.y-e.y,o=Math.sqrt(i*i+n*n);o*t.calcSize>this.thetaInversed?this._calculateForces(o,i,n,e,t):4===t.childrenCount?this._getForceContributions(t,e):t.children.data.id!=e.id&&this._calculateForces(o,i,n,e,t)}}},{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=this.options.gravitationalConstant*o.mass*n.options.mass/Math.pow(t,3),s=e*r,a=i*r;this.physicsBody.forces[n.id].x+=s,this.physicsBody.forces[n.id].y+=a}},{key:"_formBarnesHutTree",value:function(t,e){for(var i,n=e.length,o=t[e[0]].x,r=t[e[0]].y,s=t[e[0]].x,a=t[e[0]].y,h=1;h<n;h++){var l=t[e[h]],d=l.x,c=l.y;l.options.mass>0&&(d<o&&(o=d),d>s&&(s=d),c<r&&(r=c),c>a&&(a=c))}var u=Math.abs(s-o)-Math.abs(a-r);u>0?(r-=.5*u,a+=.5*u):(o+=.5*u,s-=.5*u);var f=Math.max(1e-5,Math.abs(s-o)),p=.5*f,v=.5*(o+s),g=.5*(r+a),y={root:{centerOfMass:{x:0,y:0},mass:0,range:{minX:v-p,maxX:v+p,minY:g-p,maxY:g+p},size:f,calcSize:1/f,children:{data:null},maxWidth:0,level:0,childrenCount:4}};this._splitBranch(y.root);for(var m=0;m<n;m++)(i=t[e[m]]).options.mass>0&&this._placeInTree(y.root,i);return y}},{key:"_updateBranchMass",value:function(t,e){var i=t.centerOfMass,n=t.mass+e.options.mass,o=1/n;i.x=i.x*t.mass+e.x*e.options.mass,i.x*=o,i.y=i.y*t.mass+e.y*e.options.mass,i.y*=o,t.mass=n;var r=Math.max(Math.max(e.height,e.radius),e.width);t.maxWidth=t.maxWidth<r?r:t.maxWidth}},{key:"_placeInTree",value:function(t,e,i){1==i&&void 0!==i||this._updateBranchMass(t,e);var n,o=t.children.NW.range;n=o.maxX>e.x?o.maxY>e.y?"NW":"SW":o.maxY>e.y?"NE":"SE",this._placeInRegion(t,e,n)}},{key:"_placeInRegion",value:function(t,e,i){var n=t.children[i];switch(n.childrenCount){case 0:n.children.data=e,n.childrenCount=1,this._updateBranchMass(n,e);break;case 1:n.children.data.x===e.x&&n.children.data.y===e.y?(e.x+=this._rng(),e.y+=this._rng()):(this._splitBranch(n),this._placeInTree(n,e));break;case 4:this._placeInTree(n,e)}}},{key:"_splitBranch",value:function(t){var e=null;1===t.childrenCount&&(e=t.children.data,t.mass=0,t.centerOfMass.x=0,t.centerOfMass.y=0),t.childrenCount=4,t.children.data=null,this._insertRegion(t,"NW"),this._insertRegion(t,"NE"),this._insertRegion(t,"SW"),this._insertRegion(t,"SE"),null!=e&&this._placeInTree(t,e)}},{key:"_insertRegion",value:function(t,e){var i,n,o,r,s=.5*t.size;switch(e){case"NW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY,r=t.range.minY+s;break;case"NE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY,r=t.range.minY+s;break;case"SW":i=t.range.minX,n=t.range.minX+s,o=t.range.minY+s,r=t.range.maxY;break;case"SE":i=t.range.minX+s,n=t.range.maxX,o=t.range.minY+s,r=t.range.maxY}t.children[e]={centerOfMass:{x:0,y:0},mass:0,range:{minX:i,maxX:n,minY:o,maxY:r},size:.5*t.size,calcSize:2*t.calcSize,children:{data:null},maxWidth:0,level:t.level+1,childrenCount:0}}},{key:"_debug",value:function(t,e){void 0!==this.barnesHutTree&&(t.lineWidth=1,this._drawBranch(this.barnesHutTree.root,t,e))}},{key:"_drawBranch",value:function(t,e,i){void 0===i&&(i="#FF0000"),4===t.childrenCount&&(this._drawBranch(t.children.NW,e),this._drawBranch(t.children.NE,e),this._drawBranch(t.children.SE,e),this._drawBranch(t.children.SW,e)),e.strokeStyle=i,e.beginPath(),e.moveTo(t.range.minX,t.range.minY),e.lineTo(t.range.maxX,t.range.minY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.minY),e.lineTo(t.range.maxX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.maxX,t.range.maxY),e.lineTo(t.range.minX,t.range.maxY),e.stroke(),e.beginPath(),e.moveTo(t.range.minX,t.range.maxY),e.lineTo(t.range.minX,t.range.minY),e.stroke()}}]),t}(),op=function(){function t(e,i,n){Nn(this,t),this._rng=ah("REPULSION SOLVER"),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h=this.body.nodes,l=this.physicsBody.physicsNodeIndices,d=this.physicsBody.forces,c=this.options.nodeDistance,u=-2/3/c,f=0;f<l.length-1;f++){s=h[l[f]];for(var p=f+1;p<l.length;p++)t=(a=h[l[p]]).x-s.x,e=a.y-s.y,0===(i=Math.sqrt(t*t+e*e))&&(t=i=.1*this._rng()),i<2*c&&(r=i<.5*c?1:u*i+1.3333333333333333,n=t*(r/=i),o=e*r,d[s.id].x-=n,d[s.id].y-=o,d[a.id].x+=n,d[a.id].y+=o)}}}]),t}(),rp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t,this.overlapAvoidanceFactor=Math.max(0,Math.min(1,this.options.avoidOverlap||0))}},{key:"solve",value:function(){for(var t=this.body.nodes,e=this.physicsBody.physicsNodeIndices,i=this.physicsBody.forces,n=this.options.nodeDistance,o=0;o<e.length-1;o++)for(var r=t[e[o]],s=o+1;s<e.length;s++){var a=t[e[s]];if(r.level===a.level){var h=n+this.overlapAvoidanceFactor*((r.shape.radius||0)/2+(a.shape.radius||0)/2),l=a.x-r.x,d=a.y-r.y,c=Math.sqrt(l*l+d*d),u=void 0;u=c<h?-Math.pow(.05*c,2)+Math.pow(.05*h,2):0,0!==c&&(u/=c);var f=l*u,p=d*u;i[r.id].x-=f,i[r.id].y-=p,i[a.id].x+=f,i[a.id].y+=p}}}}]),t}(),sp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r=this.physicsBody.physicsEdgeIndices,s=this.body.edges,a=0;a<r.length;a++)!0===(e=s[r[a]]).connected&&e.toId!==e.fromId&&void 0!==this.body.nodes[e.toId]&&void 0!==this.body.nodes[e.fromId]&&(void 0!==e.edgeType.via?(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.to,n=e.edgeType.via,o=e.from,this._calculateSpringForce(i,n,.5*t),this._calculateSpringForce(n,o,.5*t)):(t=void 0===e.options.length?1.5*this.options.springLength:e.options.length,this._calculateSpringForce(e.from,e.to,t)))}},{key:"_calculateSpringForce",value:function(t,e,i){var n=t.x-e.x,o=t.y-e.y,r=Math.max(Math.sqrt(n*n+o*o),.01),s=this.options.springConstant*(i-r)/r,a=n*s,h=o*s;void 0!==this.physicsBody.forces[t.id]&&(this.physicsBody.forces[t.id].x+=a,this.physicsBody.forces[t.id].y+=h),void 0!==this.physicsBody.forces[e.id]&&(this.physicsBody.forces[e.id].x-=a,this.physicsBody.forces[e.id].y-=h)}}]),t}(),ap=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o,r,s,a,h,l,d=this.body.edges,c=.5,u=this.physicsBody.physicsEdgeIndices,f=this.physicsBody.physicsNodeIndices,p=this.physicsBody.forces,v=0;v<f.length;v++){var g=f[v];p[g].springFx=0,p[g].springFy=0}for(var y=0;y<u.length;y++)!0===(e=d[u[y]]).connected&&(t=void 0===e.options.length?this.options.springLength:e.options.length,i=e.from.x-e.to.x,n=e.from.y-e.to.y,a=0===(a=Math.sqrt(i*i+n*n))?.01:a,o=i*(s=this.options.springConstant*(t-a)/a),r=n*s,e.to.level!=e.from.level?(void 0!==p[e.toId]&&(p[e.toId].springFx-=o,p[e.toId].springFy-=r),void 0!==p[e.fromId]&&(p[e.fromId].springFx+=o,p[e.fromId].springFy+=r)):(void 0!==p[e.toId]&&(p[e.toId].x-=c*o,p[e.toId].y-=c*r),void 0!==p[e.fromId]&&(p[e.fromId].x+=c*o,p[e.fromId].y+=c*r)));s=1;for(var m=0;m<f.length;m++){var b=f[m];h=Math.min(s,Math.max(-s,p[b].springFx)),l=Math.min(s,Math.max(-s,p[b].springFy)),p[b].x+=h,p[b].y+=l}for(var w=0,k=0,_=0;_<f.length;_++){var x=f[_];w+=p[x].x,k+=p[x].y}for(var E=w/f.length,O=k/f.length,C=0;C<f.length;C++){var S=f[C];p[S].x-=E,p[S].y-=O}}}]),t}(),hp=function(){function t(e,i,n){Nn(this,t),this.body=e,this.physicsBody=i,this.setOptions(n)}return Fn(t,[{key:"setOptions",value:function(t){this.options=t}},{key:"solve",value:function(){for(var t,e,i,n,o=this.body.nodes,r=this.physicsBody.physicsNodeIndices,s=this.physicsBody.forces,a=0;a<r.length;a++){t=-(n=o[r[a]]).x,e=-n.y,i=Math.sqrt(t*t+e*e),this._calculateForces(i,t,e,s,n)}}},{key:"_calculateForces",value:function(t,e,i,n,o){var r=0===t?0:this.options.centralGravity/t;n[o.id].x=e*r,n[o.id].y=i*r}}]),t}();function lp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var dp=function(t){Ad(i,t);var e=lp(i);function i(t,n,o){var r;return Nn(this,i),(r=e.call(this,t,n,o))._rng=ah("FORCE ATLAS 2 BASED REPULSION SOLVER"),r}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){0===t&&(e=t=.1*this._rng()),this.overlapAvoidanceFactor<1&&n.shape.radius&&(t=Math.max(.1+this.overlapAvoidanceFactor*n.shape.radius,t-n.shape.radius));var r=n.edges.length+1,s=this.options.gravitationalConstant*o.mass*n.options.mass*r/Math.pow(t,2),a=e*s,h=i*s;this.physicsBody.forces[n.id].x+=a,this.physicsBody.forces[n.id].y+=h}}]),i}(np);function cp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var up=function(t){Ad(i,t);var e=cp(i);function i(t,n,o){return Nn(this,i),e.call(this,t,n,o)}return Fn(i,[{key:"_calculateForces",value:function(t,e,i,n,o){if(t>0){var r=o.edges.length+1,s=this.options.centralGravity*r*o.options.mass;n[o.id].x=e*s,n[o.id].y=i*s}}}]),i}(hp),fp=function(){function t(e){Nn(this,t),this.body=e,this.physicsBody={physicsNodeIndices:[],physicsEdgeIndices:[],forces:{},velocities:{}},this.physicsEnabled=!0,this.simulationInterval=1e3/60,this.requiresTimeout=!0,this.previousStates={},this.referenceState={},this.freezeCache={},this.renderTimer=void 0,this.adaptiveTimestep=!1,this.adaptiveTimestepEnabled=!1,this.adaptiveCounter=0,this.adaptiveInterval=3,this.stabilized=!1,this.startedStabilization=!1,this.stabilizationIterations=0,this.ready=!1,this.options={},this.defaultOptions={enabled:!0,barnesHut:{theta:.5,gravitationalConstant:-2e3,centralGravity:.3,springLength:95,springConstant:.04,damping:.09,avoidOverlap:0},forceAtlas2Based:{theta:.5,gravitationalConstant:-50,centralGravity:.01,springConstant:.08,springLength:100,damping:.4,avoidOverlap:0},repulsion:{centralGravity:.2,springLength:200,springConstant:.05,nodeDistance:100,damping:.09,avoidOverlap:0},hierarchicalRepulsion:{centralGravity:0,springLength:100,springConstant:.01,nodeDistance:120,damping:.09},maxVelocity:50,minVelocity:.75,solver:"barnesHut",stabilization:{enabled:!0,iterations:1e3,updateInterval:50,onlyDynamicEdges:!1,fit:!0},timestep:.5,adaptiveTimestep:!0,wind:{x:0,y:0}},At(this.options,this.defaultOptions),this.timestep=.5,this.layoutFailed=!1,this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("initPhysics",(function(){t.initPhysics()})),this.body.emitter.on("_layoutFailed",(function(){t.layoutFailed=!0})),this.body.emitter.on("resetPhysics",(function(){t.stopSimulation(),t.ready=!1})),this.body.emitter.on("disablePhysics",(function(){t.physicsEnabled=!1,t.stopSimulation()})),this.body.emitter.on("restorePhysics",(function(){t.setOptions(t.options),!0===t.ready&&t.startSimulation()})),this.body.emitter.on("startSimulation",(function(){!0===t.ready&&t.startSimulation()})),this.body.emitter.on("stopSimulation",(function(){t.stopSimulation()})),this.body.emitter.on("destroy",(function(){t.stopSimulation(!1),t.body.emitter.off()})),this.body.emitter.on("_dataChanged",(function(){t.updatePhysicsData()}))}},{key:"setOptions",value:function(t){if(void 0!==t)if(!1===t)this.options.enabled=!1,this.physicsEnabled=!1,this.stopSimulation();else if(!0===t)this.options.enabled=!0,this.physicsEnabled=!0,this.startSimulation();else{this.physicsEnabled=!0,Oh(["stabilization"],this.options,t),$h(this.options,t,"stabilization"),void 0===t.enabled&&(this.options.enabled=!0),!1===this.options.enabled&&(this.physicsEnabled=!1,this.stopSimulation());var e=this.options.wind;e&&(("number"!=typeof e.x||yd(e.x))&&(e.x=0),("number"!=typeof e.y||yd(e.y))&&(e.y=0)),this.timestep=this.options.timestep}this.init()}},{key:"init",value:function(){var t;"forceAtlas2Based"===this.options.solver?(t=this.options.forceAtlas2Based,this.nodesSolver=new dp(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new up(this.body,this.physicsBody,t)):"repulsion"===this.options.solver?(t=this.options.repulsion,this.nodesSolver=new op(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):"hierarchicalRepulsion"===this.options.solver?(t=this.options.hierarchicalRepulsion,this.nodesSolver=new rp(this.body,this.physicsBody,t),this.edgesSolver=new ap(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)):(t=this.options.barnesHut,this.nodesSolver=new np(this.body,this.physicsBody,t),this.edgesSolver=new sp(this.body,this.physicsBody,t),this.gravitySolver=new hp(this.body,this.physicsBody,t)),this.modelOptions=t}},{key:"initPhysics",value:function(){!0===this.physicsEnabled&&!0===this.options.enabled?!0===this.options.stabilization.enabled?this.stabilize():(this.stabilized=!1,this.ready=!0,this.body.emitter.emit("fit",{},this.layoutFailed),this.startSimulation()):(this.ready=!0,this.body.emitter.emit("fit"))}},{key:"startSimulation",value:function(){var t;!0===this.physicsEnabled&&!0===this.options.enabled?(this.stabilized=!1,this.adaptiveTimestep=!1,this.body.emitter.emit("_resizeNodes"),void 0===this.viewFunction&&(this.viewFunction=Vt(t=this.simulationStep).call(t,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering"))):this.body.emitter.emit("_redraw")}},{key:"stopSimulation",value:function(){var t=!(arguments.length>0&&void 0!==arguments[0])||arguments[0];this.stabilized=!0,!0===t&&this._emitStabilized(),void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.viewFunction=void 0,!0===t&&this.body.emitter.emit("_stopRendering"))}},{key:"simulationStep",value:function(){var t=No();this.physicsTick(),(No()-t<.4*this.simulationInterval||!0===this.runDoubleSpeed)&&!1===this.stabilized&&(this.physicsTick(),this.runDoubleSpeed=!0),!0===this.stabilized&&this.stopSimulation()}},{key:"_emitStabilized",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.stabilizationIterations;(this.stabilizationIterations>1||!0===this.startedStabilization)&&rs((function(){t.body.emitter.emit("stabilized",{iterations:e}),t.startedStabilization=!1,t.stabilizationIterations=0}),0)}},{key:"physicsStep",value:function(){this.gravitySolver.solve(),this.nodesSolver.solve(),this.edgesSolver.solve(),this.moveNodes()}},{key:"adjustTimeStep",value:function(){!0===this._evaluateStepQuality()?this.timestep=1.2*this.timestep:this.timestep/1.2<this.options.timestep?this.timestep=this.options.timestep:(this.adaptiveCounter=-1,this.timestep=Math.max(this.options.timestep,this.timestep/1.2))}},{key:"physicsTick",value:function(){if(this._startStabilizing(),!0!==this.stabilized){if(!0===this.adaptiveTimestep&&!0===this.adaptiveTimestepEnabled)this.adaptiveCounter%this.adaptiveInterval==0?(this.timestep=2*this.timestep,this.physicsStep(),this.revert(),this.timestep=.5*this.timestep,this.physicsStep(),this.physicsStep(),this.adjustTimeStep()):this.physicsStep(),this.adaptiveCounter+=1;else this.timestep=this.options.timestep,this.physicsStep();!0===this.stabilized&&this.revert(),this.stabilizationIterations++}}},{key:"updatePhysicsData",value:function(){this.physicsBody.forces={},this.physicsBody.physicsNodeIndices=[],this.physicsBody.physicsEdgeIndices=[];var t=this.body.nodes,e=this.body.edges;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&!0===t[i].options.physics&&this.physicsBody.physicsNodeIndices.push(t[i].id);for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&!0===e[n].options.physics&&this.physicsBody.physicsEdgeIndices.push(e[n].id);for(var o=0;o<this.physicsBody.physicsNodeIndices.length;o++){var r=this.physicsBody.physicsNodeIndices[o];this.physicsBody.forces[r]={x:0,y:0},void 0===this.physicsBody.velocities[r]&&(this.physicsBody.velocities[r]={x:0,y:0})}for(var s in this.physicsBody.velocities)void 0===t[s]&&delete this.physicsBody.velocities[s]}},{key:"revert",value:function(){var t=zo(this.previousStates),e=this.body.nodes,i=this.physicsBody.velocities;this.referenceState={};for(var n=0;n<t.length;n++){var o=t[n];void 0!==e[o]?!0===e[o].options.physics&&(this.referenceState[o]={positions:{x:e[o].x,y:e[o].y}},i[o].x=this.previousStates[o].vx,i[o].y=this.previousStates[o].vy,e[o].x=this.previousStates[o].x,e[o].y=this.previousStates[o].y):delete this.previousStates[o]}}},{key:"_evaluateStepQuality",value:function(){var t,e,i=this.body.nodes,n=this.referenceState;for(var o in this.referenceState)if(Object.prototype.hasOwnProperty.call(this.referenceState,o)&&void 0!==i[o]&&(t=i[o].x-n[o].positions.x,e=i[o].y-n[o].positions.y,Math.sqrt(Math.pow(t,2)+Math.pow(e,2))>.3))return!1;return!0}},{key:"moveNodes",value:function(){for(var t=this.physicsBody.physicsNodeIndices,e=0,i=0,n=0;n<t.length;n++){var o=t[n],r=this._performStep(o);e=Math.max(e,r),i+=r}this.adaptiveTimestepEnabled=i/t.length<5,this.stabilized=e<this.options.minVelocity}},{key:"calculateComponentVelocity",value:function(t,e,i){t+=(e-this.modelOptions.damping*t)/i*this.timestep;var n=this.options.maxVelocity||1e9;return Math.abs(t)>n&&(t=t>0?n:-n),t}},{key:"_performStep",value:function(t){var e=this.body.nodes[t],i=this.physicsBody.forces[t];this.options.wind&&(i.x+=this.options.wind.x,i.y+=this.options.wind.y);var n=this.physicsBody.velocities[t];return this.previousStates[t]={x:e.x,y:e.y,vx:n.x,vy:n.y},!1===e.options.fixed.x?(n.x=this.calculateComponentVelocity(n.x,i.x,e.options.mass),e.x+=n.x*this.timestep):(i.x=0,n.x=0),!1===e.options.fixed.y?(n.y=this.calculateComponentVelocity(n.y,i.y,e.options.mass),e.y+=n.y*this.timestep):(i.y=0,n.y=0),Math.sqrt(Math.pow(n.x,2)+Math.pow(n.y,2))}},{key:"_freezeNodes",value:function(){var t=this.body.nodes;for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].x&&t[e].y){var i=t[e].options.fixed;this.freezeCache[e]={x:i.x,y:i.y},i.x=!0,i.y=!0}}},{key:"_restoreFrozenNodes",value:function(){var t=this.body.nodes;for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&void 0!==this.freezeCache[e]&&(t[e].options.fixed.x=this.freezeCache[e].x,t[e].options.fixed.y=this.freezeCache[e].y);this.freezeCache={}}},{key:"stabilize",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.stabilization.iterations;"number"!=typeof e&&(e=this.options.stabilization.iterations,console.error("The stabilize method needs a numeric amount of iterations. Switching to default: ",e)),0!==this.physicsBody.physicsNodeIndices.length?(this.adaptiveTimestep=this.options.adaptiveTimestep,this.body.emitter.emit("_resizeNodes"),this.stopSimulation(),this.stabilized=!1,this.body.emitter.emit("_blockRedraw"),this.targetIterations=e,!0===this.options.stabilization.onlyDynamicEdges&&this._freezeNodes(),this.stabilizationIterations=0,rs((function(){return t._stabilizationBatch()}),0)):this.ready=!0}},{key:"_startStabilizing",value:function(){return!0!==this.startedStabilization&&(this.body.emitter.emit("startStabilizing"),this.startedStabilization=!0,!0)}},{key:"_stabilizationBatch",value:function(){var t=this,e=function(){return!1===t.stabilized&&t.stabilizationIterations<t.targetIterations},i=function(){t.body.emitter.emit("stabilizationProgress",{iterations:t.stabilizationIterations,total:t.targetIterations})};this._startStabilizing()&&i();for(var n,o=0;e()&&o<this.options.stabilization.updateInterval;)this.physicsTick(),o++;(i(),e())?rs(Vt(n=this._stabilizationBatch).call(n,this),0):this._finalizeStabilization()}},{key:"_finalizeStabilization",value:function(){this.body.emitter.emit("_allowRedraw"),!0===this.options.stabilization.fit&&this.body.emitter.emit("fit"),!0===this.options.stabilization.onlyDynamicEdges&&this._restoreFrozenNodes(),this.body.emitter.emit("stabilizationIterationsDone"),this.body.emitter.emit("_requestRedraw"),!0===this.stabilized?this._emitStabilized():this.startSimulation(),this.ready=!0}},{key:"_drawForces",value:function(t){for(var e=0;e<this.physicsBody.physicsNodeIndices.length;e++){var i=this.physicsBody.physicsNodeIndices[e],n=this.body.nodes[i],o=this.physicsBody.forces[i],r=Math.sqrt(Math.pow(o.x,2)+Math.pow(o.x,2)),s=Math.min(Math.max(5,r),15),a=3*s,h=Vh((180-180*Math.min(1,Math.max(0,.03*r)))/360,1,1),l={x:n.x+20*o.x,y:n.y+20*o.y};t.lineWidth=s,t.strokeStyle=h,t.beginPath(),t.moveTo(n.x,n.y),t.lineTo(l.x,l.y),t.stroke();var d=Math.atan2(o.y,o.x);t.fillStyle=h,jf.draw(t,{type:"arrow",point:l,angle:d,length:a}),hs(t).call(t)}}}]),t}(),pp=function(){function t(){Nn(this,t)}return Fn(t,null,[{key:"getRange",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).shape.boundingBox.left&&(r=e.shape.boundingBox.left),s<e.shape.boundingBox.right&&(s=e.shape.boundingBox.right),n>e.shape.boundingBox.top&&(n=e.shape.boundingBox.top),o<e.shape.boundingBox.bottom&&(o=e.shape.boundingBox.bottom);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"getRangeCore",value:function(t){var e,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:[],n=1e9,o=-1e9,r=1e9,s=-1e9;if(i.length>0)for(var a=0;a<i.length;a++)r>(e=t[i[a]]).x&&(r=e.x),s<e.x&&(s=e.x),n>e.y&&(n=e.y),o<e.y&&(o=e.y);return 1e9===r&&-1e9===s&&1e9===n&&-1e9===o&&(n=0,o=0,r=0,s=0),{minX:r,maxX:s,minY:n,maxY:o}}},{key:"findCenter",value:function(t){return{x:.5*(t.maxX+t.minX),y:.5*(t.maxY+t.minY)}}},{key:"cloneOptions",value:function(t,e){var i={};return void 0===e||"node"===e?(Ch(i,t.options,!0),i.x=t.x,i.y=t.y,i.amountOfConnections=t.edges.length):Ch(i,t.options,!0),i}}]),t}();function vp(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var gp=function(t){Ad(i,t);var e=vp(i);function i(t,n,o,r,s,a){var h;return Nn(this,i),(h=e.call(this,t,n,o,r,s,a)).isCluster=!0,h.containedNodes={},h.containedEdges={},h}return Fn(i,[{key:"_openChildCluster",value:function(t){var e=this,i=this.body.nodes[t];if(void 0===this.containedNodes[t])throw new Error("node with id: "+t+" not in current cluster");if(!i.isCluster)throw new Error("node with id: "+t+" is not a cluster");delete this.containedNodes[t],Dh(i.edges,(function(t){delete e.containedEdges[t.id]})),Dh(i.containedNodes,(function(t,i){e.containedNodes[i]=t})),i.containedNodes={},Dh(i.containedEdges,(function(t,i){e.containedEdges[i]=t})),i.containedEdges={},Dh(i.edges,(function(t){Dh(e.edges,(function(i){var n,o,r=Hr(n=i.clusteringEdgeReplacingIds).call(n,t.id);-1!==r&&(Dh(t.clusteringEdgeReplacingIds,(function(t){i.clusteringEdgeReplacingIds.push(t),e.body.edges[t].edgeReplacedById=i.id})),er(o=i.clusteringEdgeReplacingIds).call(o,r,1))}))})),i.edges=[]}}]),i}(cf),yp=function(){function t(e){var i=this;Nn(this,t),this.body=e,this.clusteredNodes={},this.clusteredEdges={},this.options={},this.defaultOptions={},At(this.options,this.defaultOptions),this.body.emitter.on("_resetData",(function(){i.clusteredNodes={},i.clusteredEdges={}}))}return Fn(t,[{key:"clusterByHubsize",value:function(t,e){void 0===t?t=this._getHubSize():"object"===go(t)&&(e=this._checkOptions(t),t=this._getHubSize());for(var i=[],n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodes[this.body.nodeIndices[n]];o.edges.length>=t&&i.push(o.id)}for(var r=0;r<i.length;r++)this.clusterByConnection(i[r],e,!0);this.body.emitter.emit("_dataChanged")}},{key:"cluster",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},i=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(void 0===e.joinCondition)throw new Error("Cannot call clusterByNodeData without a joinCondition function in the options.");e=this._checkOptions(e);var n={},o={};Dh(this.body.nodes,(function(i,r){i.options&&!0===e.joinCondition(i.options)&&(n[r]=i,Dh(i.edges,(function(e){void 0===t.clusteredEdges[e.id]&&(o[e.id]=e)})))})),this._cluster(n,o,e,i)}},{key:"clusterByEdgeCount",value:function(t,e){var i=this,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];e=this._checkOptions(e);for(var o,r,s,a=[],h={},l=function(n){var l={},d={},c=i.body.nodeIndices[n],u=i.body.nodes[c];if(void 0===h[c]){s=0,r=[];for(var f=0;f<u.edges.length;f++)o=u.edges[f],void 0===i.clusteredEdges[o.id]&&(o.toId!==o.fromId&&s++,r.push(o));if(s===t){for(var p=function(t){if(void 0===e.joinCondition||null===e.joinCondition)return!0;var i=pp.cloneOptions(t);return e.joinCondition(i)},v=!0,g=0;g<r.length;g++){o=r[g];var y=i._getConnectedId(o,c);if(!p(u)){v=!1;break}d[o.id]=o,l[c]=u,l[y]=i.body.nodes[y],h[c]=!0}if(zo(l).length>0&&zo(d).length>0&&!0===v){var m=function(){for(var t=0;t<a.length;++t)for(var e in l)if(void 0!==a[t].nodes[e])return a[t]}();if(void 0!==m){for(var b in l)void 0===m.nodes[b]&&(m.nodes[b]=l[b]);for(var w in d)void 0===m.edges[w]&&(m.edges[w]=d[w])}else a.push({nodes:l,edges:d})}}}},d=0;d<this.body.nodeIndices.length;d++)l(d);for(var c=0;c<a.length;c++)this._cluster(a[c].nodes,a[c].edges,e,!1);!0===n&&this.body.emitter.emit("_dataChanged")}},{key:"clusterOutliers",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(1,t,e)}},{key:"clusterBridges",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];this.clusterByEdgeCount(2,t,e)}},{key:"clusterByConnection",value:function(t,e){var i,n=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No nodeId supplied to clusterByConnection!");if(void 0===this.body.nodes[t])throw new Error("The nodeId given to clusterByConnection does not exist!");var o=this.body.nodes[t];void 0===(e=this._checkOptions(e,o)).clusterNodeProperties.x&&(e.clusterNodeProperties.x=o.x),void 0===e.clusterNodeProperties.y&&(e.clusterNodeProperties.y=o.y),void 0===e.clusterNodeProperties.fixed&&(e.clusterNodeProperties.fixed={},e.clusterNodeProperties.fixed.x=o.options.fixed.x,e.clusterNodeProperties.fixed.y=o.options.fixed.y);var r={},s={},a=o.id,h=pp.cloneOptions(o);r[a]=o;for(var l=0;l<o.edges.length;l++){var d=o.edges[l];if(void 0===this.clusteredEdges[d.id]){var c=this._getConnectedId(d,a);if(void 0===this.clusteredNodes[c])if(c!==a)if(void 0===e.joinCondition)s[d.id]=d,r[c]=this.body.nodes[c];else{var u=pp.cloneOptions(this.body.nodes[c]);!0===e.joinCondition(h,u)&&(s[d.id]=d,r[c]=this.body.nodes[c])}else s[d.id]=d}}var f=Io(i=zo(r)).call(i,(function(t){return r[t].id}));for(var p in r)if(Object.prototype.hasOwnProperty.call(r,p))for(var v=r[p],g=0;g<v.edges.length;g++){var y=v.edges[g];Hr(f).call(f,this._getConnectedId(y,v.id))>-1&&(s[y.id]=y)}this._cluster(r,s,e,n)}},{key:"_createClusterEdges",value:function(t,e,i,n){for(var o,r,s,a,h,l,d=zo(t),c=[],u=0;u<d.length;u++){s=t[r=d[u]];for(var f=0;f<s.edges.length;f++)o=s.edges[f],void 0===this.clusteredEdges[o.id]&&(o.toId==o.fromId?e[o.id]=o:o.toId==r?(a=i.id,l=h=o.fromId):(a=o.toId,h=i.id,l=a),void 0===t[l]&&c.push({edge:o,fromId:h,toId:a}))}for(var p=[],v=function(t){for(var e=0;e<p.length;e++){var i=p[e],n=t.fromId===i.fromId&&t.toId===i.toId,o=t.fromId===i.toId&&t.toId===i.fromId;if(n||o)return i}return null},g=0;g<c.length;g++){var y=c[g],m=y.edge,b=v(y);null===b?(b=this._createClusteredEdge(y.fromId,y.toId,m,n),p.push(b)):b.clusteringEdgeReplacingIds.push(m.id),this.body.edges[m.id].edgeReplacedById=b.id,this._backupEdgeOptions(m),m.setOptions({physics:!1})}}},{key:"_checkOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};return void 0===t.clusterEdgeProperties&&(t.clusterEdgeProperties={}),void 0===t.clusterNodeProperties&&(t.clusterNodeProperties={}),t}},{key:"_cluster",value:function(t,e,i){var n=!(arguments.length>3&&void 0!==arguments[3])||arguments[3],o=[];for(var r in t)Object.prototype.hasOwnProperty.call(t,r)&&void 0!==this.clusteredNodes[r]&&o.push(r);for(var s=0;s<o.length;++s)delete t[o[s]];if(0!=zo(t).length&&(1!=zo(t).length||1==i.clusterNodeProperties.allowSingleNodeCluster)){var a=Ch({},i.clusterNodeProperties);if(void 0!==i.processProperties){var h=[];for(var l in t)if(Object.prototype.hasOwnProperty.call(t,l)){var d=pp.cloneOptions(t[l]);h.push(d)}var c=[];for(var u in e)if(Object.prototype.hasOwnProperty.call(e,u)&&"clusterEdge:"!==u.substr(0,12)){var f=pp.cloneOptions(e[u],"edge");c.push(f)}if(!(a=i.processProperties(a,h,c)))throw new Error("The processProperties function does not return properties!")}void 0===a.id&&(a.id="cluster:"+Wc());var p=a.id;void 0===a.label&&(a.label="cluster");var v=void 0;void 0===a.x&&(v=this._getClusterPosition(t),a.x=v.x),void 0===a.y&&(void 0===v&&(v=this._getClusterPosition(t)),a.y=v.y),a.id=p;var g=this.body.functions.createNode(a,gp);g.containedNodes=t,g.containedEdges=e,g.clusterEdgeProperties=i.clusterEdgeProperties,this.body.nodes[a.id]=g,this._clusterEdges(t,e,a,i.clusterEdgeProperties),a.id=void 0,!0===n&&this.body.emitter.emit("_dataChanged")}}},{key:"_backupEdgeOptions",value:function(t){void 0===this.clusteredEdges[t.id]&&(this.clusteredEdges[t.id]={physics:t.options.physics})}},{key:"_restoreEdge",value:function(t){var e=this.clusteredEdges[t.id];void 0!==e&&(t.setOptions({physics:e.physics}),delete this.clusteredEdges[t.id])}},{key:"isCluster",value:function(t){return void 0!==this.body.nodes[t]?!0===this.body.nodes[t].isCluster:(console.error("Node does not exist."),!1)}},{key:"_getClusterPosition",value:function(t){for(var e,i=zo(t),n=t[i[0]].x,o=t[i[0]].x,r=t[i[0]].y,s=t[i[0]].y,a=1;a<i.length;a++)n=(e=t[i[a]]).x<n?e.x:n,o=e.x>o?e.x:o,r=e.y<r?e.y:r,s=e.y>s?e.y:s;return{x:.5*(n+o),y:.5*(r+s)}}},{key:"openCluster",value:function(t,e){var i=!(arguments.length>2&&void 0!==arguments[2])||arguments[2];if(void 0===t)throw new Error("No clusterNodeId supplied to openCluster.");var n=this.body.nodes[t];if(void 0===n)throw new Error("The clusterNodeId supplied to openCluster does not exist.");if(!0!==n.isCluster||void 0===n.containedNodes||void 0===n.containedEdges)throw new Error("The node:"+t+" is not a valid cluster.");var o=this.findNode(t),r=Hr(o).call(o,t)-1;if(r>=0){var s=o[r],a=this.body.nodes[s];return a._openChildCluster(t),delete this.body.nodes[t],void(!0===i&&this.body.emitter.emit("_dataChanged"))}var h=n.containedNodes,l=n.containedEdges;if(void 0!==e&&void 0!==e.releaseFunction&&"function"==typeof e.releaseFunction){var d={},c={x:n.x,y:n.y};for(var u in h)if(Object.prototype.hasOwnProperty.call(h,u)){var f=this.body.nodes[u];d[u]={x:f.x,y:f.y}}var p=e.releaseFunction(c,d);for(var v in h)if(Object.prototype.hasOwnProperty.call(h,v)){var g=this.body.nodes[v];void 0!==p[v]&&(g.x=void 0===p[v].x?n.x:p[v].x,g.y=void 0===p[v].y?n.y:p[v].y)}}else Dh(h,(function(t){!1===t.options.fixed.x&&(t.x=n.x),!1===t.options.fixed.y&&(t.y=n.y)}));for(var y in h)if(Object.prototype.hasOwnProperty.call(h,y)){var m=this.body.nodes[y];m.vx=n.vx,m.vy=n.vy,m.setOptions({physics:!0}),delete this.clusteredNodes[y]}for(var b=[],w=0;w<n.edges.length;w++)b.push(n.edges[w]);for(var k=0;k<b.length;k++){for(var _=b[k],x=this._getConnectedId(_,t),E=this.clusteredNodes[x],O=0;O<_.clusteringEdgeReplacingIds.length;O++){var C=_.clusteringEdgeReplacingIds[O],S=this.body.edges[C];if(void 0!==S)if(void 0!==E){var T=this.body.nodes[E.clusterId];T.containedEdges[S.id]=S,delete l[S.id];var M=S.fromId,P=S.toId;S.toId==x?P=E.clusterId:M=E.clusterId,this._createClusteredEdge(M,P,S,T.clusterEdgeProperties,{hidden:!1,physics:!0})}else this._restoreEdge(S)}_.remove()}for(var D in l)Object.prototype.hasOwnProperty.call(l,D)&&this._restoreEdge(l[D]);delete this.body.nodes[t],!0===i&&this.body.emitter.emit("_dataChanged")}},{key:"getNodesInCluster",value:function(t){var e=[];if(!0===this.isCluster(t)){var i=this.body.nodes[t].containedNodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&e.push(this.body.nodes[n].id)}return e}},{key:"findNode",value:function(t){for(var e,i=[],n=0;void 0!==this.clusteredNodes[t]&&n<100;){if(void 0===(e=this.body.nodes[t]))return[];i.push(e.id),t=this.clusteredNodes[t].clusterId,n++}return void 0===(e=this.body.nodes[t])?[]:(i.push(e.id),Xo(i).call(i),i)}},{key:"updateClusteredNode",value:function(t,e){if(void 0===t)throw new Error("No clusteredNodeId supplied to updateClusteredNode.");if(void 0===e)throw new Error("No newOptions supplied to updateClusteredNode.");if(void 0===this.body.nodes[t])throw new Error("The clusteredNodeId supplied to updateClusteredNode does not exist.");this.body.nodes[t].setOptions(e),this.body.emitter.emit("_dataChanged")}},{key:"updateEdge",value:function(t,e){if(void 0===t)throw new Error("No startEdgeId supplied to updateEdge.");if(void 0===e)throw new Error("No newOptions supplied to updateEdge.");if(void 0===this.body.edges[t])throw new Error("The startEdgeId supplied to updateEdge does not exist.");for(var i=this.getClusteredEdges(t),n=0;n<i.length;n++){this.body.edges[i[n]].setOptions(e)}this.body.emitter.emit("_dataChanged")}},{key:"getClusteredEdges",value:function(t){for(var e=[],i=0;void 0!==t&&void 0!==this.body.edges[t]&&i<100;)e.push(this.body.edges[t].id),t=this.body.edges[t].edgeReplacedById,i++;return Xo(e).call(e),e}},{key:"getBaseEdge",value:function(t){return this.getBaseEdges(t)[0]}},{key:"getBaseEdges",value:function(t){for(var e=[t],i=[],n=[],o=0;e.length>0&&o<100;){var r=e.pop();if(void 0!==r){var s=this.body.edges[r];if(void 0!==s){o++;var a=s.clusteringEdgeReplacingIds;if(void 0===a)n.push(r);else for(var h=0;h<a.length;++h){var l=a[h];-1===Hr(e).call(e,a)&&-1===Hr(i).call(i,a)&&e.push(l)}i.push(r)}}}return n}},{key:"_getConnectedId",value:function(t,e){return t.toId!=e?t.toId:(t.fromId,t.fromId)}},{key:"_getHubSize",value:function(){for(var t=0,e=0,i=0,n=0,o=0;o<this.body.nodeIndices.length;o++){var r=this.body.nodes[this.body.nodeIndices[o]];r.edges.length>n&&(n=r.edges.length),t+=r.edges.length,e+=Math.pow(r.edges.length,2),i+=1}t/=i;var s=(e/=i)-Math.pow(t,2),a=Math.sqrt(s),h=Math.floor(t+2*a);return h>n&&(h=n),h}},{key:"_createClusteredEdge",value:function(t,e,i,n,o){var r=pp.cloneOptions(i,"edge");Ch(r,n),r.from=t,r.to=e,r.id="clusterEdge:"+Wc(),void 0!==o&&Ch(r,o);var s=this.body.functions.createEdge(r);return s.clusteringEdgeReplacingIds=[i.id],s.connect(),this.body.edges[s.id]=s,s}},{key:"_clusterEdges",value:function(t,e,i,n){if(e instanceof ep){var o=e,r={};r[o.id]=o,e=r}if(t instanceof cf){var s=t,a={};a[s.id]=s,t=a}if(null==i)throw new Error("_clusterEdges: parameter clusterNode required");for(var h in void 0===n&&(n=i.clusterEdgeProperties),this._createClusterEdges(t,e,i,n),e)if(Object.prototype.hasOwnProperty.call(e,h)&&void 0!==this.body.edges[h]){var l=this.body.edges[h];this._backupEdgeOptions(l),l.setOptions({physics:!1})}for(var d in t)Object.prototype.hasOwnProperty.call(t,d)&&(this.clusteredNodes[d]={clusterId:i.id,node:this.body.nodes[d]},this.body.nodes[d].setOptions({physics:!1}))}},{key:"_getClusterNodeForNode",value:function(t){if(void 0!==t){var e=this.clusteredNodes[t];if(void 0!==e){var i=e.clusterId;if(void 0!==i)return this.body.nodes[i]}}}},{key:"_filter",value:function(t,e){var i=[];return Dh(t,(function(t){e(t)&&i.push(t)})),i}},{key:"_updateState",value:function(){var t,e=this,i=[],n={},o=function(t){Dh(e.body.nodes,(function(e){!0===e.isCluster&&t(e)}))};for(t in this.clusteredNodes){if(Object.prototype.hasOwnProperty.call(this.clusteredNodes,t))void 0===this.body.nodes[t]&&i.push(t)}o((function(t){for(var e=0;e<i.length;e++)delete t.containedNodes[i[e]]}));for(var r=0;r<i.length;r++)delete this.clusteredNodes[i[r]];Dh(this.clusteredEdges,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()||(n[t]=t)})),o((function(t){Dh(t.containedEdges,(function(t,e){t.endPointsValid()||n[e]||(n[e]=e)}))})),Dh(this.body.edges,(function(t,i){var o=!0,r=t.clusteringEdgeReplacingIds;if(void 0!==r){var s=0;Dh(r,(function(t){var i=e.body.edges[t];void 0!==i&&i.endPointsValid()&&(s+=1)})),o=s>0}t.endPointsValid()&&o||(n[i]=i)})),o((function(t){Dh(n,(function(i){delete t.containedEdges[i],Dh(t.edges,(function(o,r){o.id!==i?o.clusteringEdgeReplacingIds=e._filter(o.clusteringEdgeReplacingIds,(function(t){return!n[t]})):t.edges[r]=null})),t.edges=e._filter(t.edges,(function(t){return null!==t}))}))})),Dh(n,(function(t){delete e.clusteredEdges[t]})),Dh(n,(function(t){delete e.body.edges[t]})),Dh(zo(this.body.edges),(function(t){var i=e.body.edges[t],n=e._isClusteredNode(i.fromId)||e._isClusteredNode(i.toId);if(n!==e._isClusteredEdge(i.id))if(n){var o=e._getClusterNodeForNode(i.fromId);void 0!==o&&e._clusterEdges(e.body.nodes[i.fromId],i,o);var r=e._getClusterNodeForNode(i.toId);void 0!==r&&e._clusterEdges(e.body.nodes[i.toId],i,r)}else delete e._clusterEdges[t],e._restoreEdge(i)}));for(var s=!1,a=!0,h=function(){var t=[];o((function(e){var i=zo(e.containedNodes).length,n=!0===e.options.allowSingleNodeCluster;(n&&i<1||!n&&i<2)&&t.push(e.id)}));for(var i=0;i<t.length;++i)e.openCluster(t[i],{},!1);a=t.length>0,s=s||a};a;)h();s&&this._updateState()}},{key:"_isClusteredNode",value:function(t){return void 0!==this.clusteredNodes[t]}},{key:"_isClusteredEdge",value:function(t){return void 0!==this.clusteredEdges[t]}}]),t}();function mp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return bp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return bp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function bp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var wp=function(){function t(e,i){var n;Nn(this,t),void 0!==window&&(n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||window.msRequestAnimationFrame),window.requestAnimationFrame=void 0===n?function(t){t()}:n,this.body=e,this.canvas=i,this.redrawRequested=!1,this.renderTimer=void 0,this.requiresTimeout=!0,this.renderingActive=!1,this.renderRequests=0,this.allowRedraw=!0,this.dragging=!1,this.zooming=!1,this.options={},this.defaultOptions={hideEdgesOnDrag:!1,hideEdgesOnZoom:!1,hideNodesOnDrag:!1},At(this.options,this.defaultOptions),this._determineBrowserMethod(),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.on("dragStart",(function(){e.dragging=!0})),this.body.emitter.on("dragEnd",(function(){e.dragging=!1})),this.body.emitter.on("zoom",(function(){e.zooming=!0,window.clearTimeout(e.zoomTimeoutId),e.zoomTimeoutId=rs((function(){var t;e.zooming=!1,Vt(t=e._requestRedraw).call(t,e)()}),250)})),this.body.emitter.on("_resizeNodes",(function(){e._resizeNodes()})),this.body.emitter.on("_redraw",(function(){!1===e.renderingActive&&e._redraw()})),this.body.emitter.on("_blockRedraw",(function(){e.allowRedraw=!1})),this.body.emitter.on("_allowRedraw",(function(){e.allowRedraw=!0,e.redrawRequested=!1})),this.body.emitter.on("_requestRedraw",Vt(t=this._requestRedraw).call(t,this)),this.body.emitter.on("_startRendering",(function(){e.renderRequests+=1,e.renderingActive=!0,e._startRendering()})),this.body.emitter.on("_stopRendering",(function(){e.renderRequests-=1,e.renderingActive=e.renderRequests>0,e.renderTimer=void 0})),this.body.emitter.on("destroy",(function(){e.renderRequests=0,e.allowRedraw=!1,e.renderingActive=!1,!0===e.requiresTimeout?clearTimeout(e.renderTimer):window.cancelAnimationFrame(e.renderTimer),e.body.emitter.off()}))}},{key:"setOptions",value:function(t){if(void 0!==t){Eh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag"],this.options,t)}}},{key:"_requestNextFrame",value:function(t,e){if("undefined"!=typeof window){var i,n=window;return!0===this.requiresTimeout?i=rs(t,e):n.requestAnimationFrame&&(i=n.requestAnimationFrame(t)),i}}},{key:"_startRendering",value:function(){var t;!0===this.renderingActive&&(void 0===this.renderTimer&&(this.renderTimer=this._requestNextFrame(Vt(t=this._renderStep).call(t,this),this.simulationInterval)))}},{key:"_renderStep",value:function(){!0===this.renderingActive&&(this.renderTimer=void 0,!0===this.requiresTimeout&&this._startRendering(),this._redraw(),!1===this.requiresTimeout&&this._startRendering())}},{key:"redraw",value:function(){this.body.emitter.emit("setSize"),this._redraw()}},{key:"_requestRedraw",value:function(){var t=this;!0!==this.redrawRequested&&!1===this.renderingActive&&!0===this.allowRedraw&&(this.redrawRequested=!0,this._requestNextFrame((function(){t._redraw(!1)}),0))}},{key:"_redraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!0===this.allowRedraw){this.body.emitter.emit("initRedraw"),this.redrawRequested=!1;var e={drawExternalLabels:null};0!==this.canvas.frame.canvas.width&&0!==this.canvas.frame.canvas.height||this.canvas.setSize(),this.canvas.setTransform();var i=this.canvas.getContext(),n=this.canvas.frame.canvas.clientWidth,o=this.canvas.frame.canvas.clientHeight;if(i.clearRect(0,0,n,o),0===this.canvas.frame.clientWidth)return;if(i.save(),i.translate(this.body.view.translation.x,this.body.view.translation.y),i.scale(this.body.view.scale,this.body.view.scale),i.beginPath(),this.body.emitter.emit("beforeDrawing",i),i.closePath(),!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawEdges(i),!1===this.dragging||!0===this.dragging&&!1===this.options.hideNodesOnDrag){var r=this._drawNodes(i,t),s=r.drawExternalLabels;e.drawExternalLabels=s}!1===t&&(!1===this.dragging||!0===this.dragging&&!1===this.options.hideEdgesOnDrag)&&(!1===this.zooming||!0===this.zooming&&!1===this.options.hideEdgesOnZoom)&&this._drawArrows(i),null!=e.drawExternalLabels&&e.drawExternalLabels(),!1===t&&this._drawSelectionBox(i),i.beginPath(),this.body.emitter.emit("afterDrawing",i),i.closePath(),i.restore(),!0===t&&i.clearRect(0,0,n,o)}}},{key:"_resizeNodes",value:function(){this.canvas.setTransform();var t=this.canvas.getContext();t.save(),t.translate(this.body.view.translation.x,this.body.view.translation.y),t.scale(this.body.view.scale,this.body.view.scale);var e,i=this.body.nodes;for(var n in i)Object.prototype.hasOwnProperty.call(i,n)&&((e=i[n]).resize(t),e.updateBoundingBox(t,e.selected));t.restore()}},{key:"_drawNodes",value:function(t){for(var e,i,n=arguments.length>1&&void 0!==arguments[1]&&arguments[1],o=this.body.nodes,r=this.body.nodeIndices,s=[],a=[],h=20,l=this.canvas.DOMtoCanvas({x:-h,y:-h}),d=this.canvas.DOMtoCanvas({x:this.canvas.frame.canvas.clientWidth+h,y:this.canvas.frame.canvas.clientHeight+h}),c={top:l.y,left:l.x,bottom:d.y,right:d.x},u=[],f=0;f<r.length;f++)if((e=o[r[f]]).hover)a.push(r[f]);else if(e.isSelected())s.push(r[f]);else if(!0===n){var p=e.draw(t);null!=p.drawExternalLabel&&u.push(p.drawExternalLabel)}else if(!0===e.isBoundingBoxOverlappingWith(c)){var v=e.draw(t);null!=v.drawExternalLabel&&u.push(v.drawExternalLabel)}else e.updateBoundingBox(t,e.selected);var g=s.length,y=a.length;for(i=0;i<g;i++){var m=(e=o[s[i]]).draw(t);null!=m.drawExternalLabel&&u.push(m.drawExternalLabel)}for(i=0;i<y;i++){var b=(e=o[a[i]]).draw(t);null!=b.drawExternalLabel&&u.push(b.drawExternalLabel)}return{drawExternalLabels:function(){var t,e=mp(u);try{for(e.s();!(t=e.n()).done;){(0,t.value)()}}catch(t){e.e(t)}finally{e.f()}}}}},{key:"_drawEdges",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.draw(t)}}},{key:"_drawArrows",value:function(t){for(var e=this.body.edges,i=this.body.edgeIndices,n=0;n<i.length;n++){var o=e[i[n]];!0===o.connected&&o.drawArrows(t)}}},{key:"_determineBrowserMethod",value:function(){if("undefined"!=typeof window){var t=navigator.userAgent.toLowerCase();this.requiresTimeout=!1,(-1!=Hr(t).call(t,"msie 9.0")||-1!=Hr(t).call(t,"safari")&&Hr(t).call(t,"chrome")<=-1)&&(this.requiresTimeout=!0)}else this.requiresTimeout=!0}},{key:"_drawSelectionBox",value:function(t){if(this.body.selectionBox.show){t.beginPath();var e=this.body.selectionBox.position.end.x-this.body.selectionBox.position.start.x,i=this.body.selectionBox.position.end.y-this.body.selectionBox.position.start.y;t.rect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.fillStyle="rgba(151, 194, 252, 0.2)",t.fillRect(this.body.selectionBox.position.start.x,this.body.selectionBox.position.start.y,e,i),t.strokeStyle="rgba(151, 194, 252, 1)",t.stroke()}else t.closePath()}}]),t}(),kp=k.setInterval;function _p(t,e){e.inputHandler=function(t){t.isFirst&&e(t)},t.on("hammer.input",e.inputHandler)}function xp(t,e){return e.inputHandler=function(t){t.isFinal&&e(t)},t.on("hammer.input",e.inputHandler)}var Ep=function(){function t(e){Nn(this,t),this.body=e,this.pixelRatio=1,this.cameraState={},this.initialized=!1,this.canvasViewCenter={},this._cleanupCallbacks=[],this.options={},this.defaultOptions={autoResize:!0,height:"100%",width:"100%"},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t,e=this;this.body.emitter.once("resize",(function(t){0!==t.width&&(e.body.view.translation.x=.5*t.width),0!==t.height&&(e.body.view.translation.y=.5*t.height)})),this.body.emitter.on("setSize",Vt(t=this.setSize).call(t,this)),this.body.emitter.on("destroy",(function(){e.hammerFrame.destroy(),e.hammer.destroy(),e._cleanUp()}))}},{key:"setOptions",value:function(t){var e=this;if(void 0!==t){Eh(["width","height","autoResize"],this.options,t)}if(this._cleanUp(),!0===this.options.autoResize){var i;if(window.ResizeObserver){var n=new ResizeObserver((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")})),o=this.frame;n.observe(o),this._cleanupCallbacks.push((function(){n.unobserve(o)}))}else{var r=kp((function(){!0===e.setSize()&&e.body.emitter.emit("_requestRedraw")}),1e3);this._cleanupCallbacks.push((function(){clearInterval(r)}))}var s=Vt(i=this._onResize).call(i,this);Bh(window,"resize",s),this._cleanupCallbacks.push((function(){zh(window,"resize",s)}))}}},{key:"_cleanUp",value:function(){var t,e,i;Wo(t=Xo(e=er(i=this._cleanupCallbacks).call(i,0)).call(e)).call(t,(function(t){try{t()}catch(t){console.error(t)}}))}},{key:"_onResize",value:function(){this.setSize(),this.body.emitter.emit("_redraw")}},{key:"_getCameraState",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.pixelRatio;!0===this.initialized&&(this.cameraState.previousWidth=this.frame.canvas.width/t,this.cameraState.previousHeight=this.frame.canvas.height/t,this.cameraState.scale=this.body.view.scale,this.cameraState.position=this.DOMtoCanvas({x:.5*this.frame.canvas.width/t,y:.5*this.frame.canvas.height/t}))}},{key:"_setCameraState",value:function(){if(void 0!==this.cameraState.scale&&0!==this.frame.canvas.clientWidth&&0!==this.frame.canvas.clientHeight&&0!==this.pixelRatio&&this.cameraState.previousWidth>0&&this.cameraState.previousHeight>0){var t=this.frame.canvas.width/this.pixelRatio/this.cameraState.previousWidth,e=this.frame.canvas.height/this.pixelRatio/this.cameraState.previousHeight,i=this.cameraState.scale;1!=t&&1!=e?i=.5*this.cameraState.scale*(t+e):1!=t?i=this.cameraState.scale*t:1!=e&&(i=this.cameraState.scale*e),this.body.view.scale=i;var n=this.DOMtoCanvas({x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight}),o={x:n.x-this.cameraState.position.x,y:n.y-this.cameraState.position.y};this.body.view.translation.x+=o.x*this.body.view.scale,this.body.view.translation.y+=o.y*this.body.view.scale}}},{key:"_prepareValue",value:function(t){if("number"==typeof t)return t+"px";if("string"==typeof t){if(-1!==Hr(t).call(t,"%")||-1!==Hr(t).call(t,"px"))return t;if(-1===Hr(t).call(t,"%"))return t+"px"}throw new Error("Could not use the value supplied for width or height:"+t)}},{key:"_create",value:function(){for(;this.body.container.hasChildNodes();)this.body.container.removeChild(this.body.container.firstChild);if(this.frame=document.createElement("div"),this.frame.className="vis-network",this.frame.style.position="relative",this.frame.style.overflow="hidden",this.frame.tabIndex=0,this.frame.canvas=document.createElement("canvas"),this.frame.canvas.style.position="relative",this.frame.appendChild(this.frame.canvas),this.frame.canvas.getContext)this._setPixelRatio(),this.setTransform();else{var t=document.createElement("DIV");t.style.color="red",t.style.fontWeight="bold",t.style.padding="10px",t.innerText="Error: your browser does not support HTML canvas",this.frame.canvas.appendChild(t)}this.body.container.appendChild(this.frame),this.body.view.scale=1,this.body.view.translation={x:.5*this.frame.canvas.clientWidth,y:.5*this.frame.canvas.clientHeight},this._bindHammer()}},{key:"_bindHammer",value:function(){var t=this;void 0!==this.hammer&&this.hammer.destroy(),this.drag={},this.pinch={},this.hammer=new ll(this.frame.canvas),this.hammer.get("pinch").set({enable:!0}),this.hammer.get("pan").set({threshold:5,direction:ll.DIRECTION_ALL}),_p(this.hammer,(function(e){t.body.eventListeners.onTouch(e)})),this.hammer.on("tap",(function(e){t.body.eventListeners.onTap(e)})),this.hammer.on("doubletap",(function(e){t.body.eventListeners.onDoubleTap(e)})),this.hammer.on("press",(function(e){t.body.eventListeners.onHold(e)})),this.hammer.on("panstart",(function(e){t.body.eventListeners.onDragStart(e)})),this.hammer.on("panmove",(function(e){t.body.eventListeners.onDrag(e)})),this.hammer.on("panend",(function(e){t.body.eventListeners.onDragEnd(e)})),this.hammer.on("pinch",(function(e){t.body.eventListeners.onPinch(e)})),this.frame.canvas.addEventListener("wheel",(function(e){t.body.eventListeners.onMouseWheel(e)})),this.frame.canvas.addEventListener("mousemove",(function(e){t.body.eventListeners.onMouseMove(e)})),this.frame.canvas.addEventListener("contextmenu",(function(e){t.body.eventListeners.onContext(e)})),this.hammerFrame=new ll(this.frame),xp(this.hammerFrame,(function(e){t.body.eventListeners.onRelease(e)}))}},{key:"setSize",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:this.options.width,e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.height;t=this._prepareValue(t),e=this._prepareValue(e);var i=!1,n=this.frame.canvas.width,o=this.frame.canvas.height,r=this.pixelRatio;if(this._setPixelRatio(),t!=this.options.width||e!=this.options.height||this.frame.style.width!=t||this.frame.style.height!=e)this._getCameraState(r),this.frame.style.width=t,this.frame.style.height=e,this.frame.canvas.style.width="100%",this.frame.canvas.style.height="100%",this.frame.canvas.width=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),this.frame.canvas.height=Math.round(this.frame.canvas.clientHeight*this.pixelRatio),this.options.width=t,this.options.height=e,this.canvasViewCenter={x:.5*this.frame.clientWidth,y:.5*this.frame.clientHeight},i=!0;else{var s=Math.round(this.frame.canvas.clientWidth*this.pixelRatio),a=Math.round(this.frame.canvas.clientHeight*this.pixelRatio);this.frame.canvas.width===s&&this.frame.canvas.height===a||this._getCameraState(r),this.frame.canvas.width!==s&&(this.frame.canvas.width=s,i=!0),this.frame.canvas.height!==a&&(this.frame.canvas.height=a,i=!0)}return!0===i&&(this.body.emitter.emit("resize",{width:Math.round(this.frame.canvas.width/this.pixelRatio),height:Math.round(this.frame.canvas.height/this.pixelRatio),oldWidth:Math.round(n/this.pixelRatio),oldHeight:Math.round(o/this.pixelRatio)}),this._setCameraState()),this.initialized=!0,i}},{key:"getContext",value:function(){return this.frame.canvas.getContext("2d")}},{key:"_determinePixelRatio",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");var e=1;return"undefined"!=typeof window&&(e=window.devicePixelRatio||1),e/(t.webkitBackingStorePixelRatio||t.mozBackingStorePixelRatio||t.msBackingStorePixelRatio||t.oBackingStorePixelRatio||t.backingStorePixelRatio||1)}},{key:"_setPixelRatio",value:function(){this.pixelRatio=this._determinePixelRatio()}},{key:"setTransform",value:function(){var t=this.getContext();if(void 0===t)throw new Error("Could not get canvax context");t.setTransform(this.pixelRatio,0,0,this.pixelRatio,0,0)}},{key:"_XconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.x)/this.body.view.scale}},{key:"_XconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.x}},{key:"_YconvertDOMtoCanvas",value:function(t){return(t-this.body.view.translation.y)/this.body.view.scale}},{key:"_YconvertCanvasToDOM",value:function(t){return t*this.body.view.scale+this.body.view.translation.y}},{key:"canvasToDOM",value:function(t){return{x:this._XconvertCanvasToDOM(t.x),y:this._YconvertCanvasToDOM(t.y)}}},{key:"DOMtoCanvas",value:function(t){return{x:this._XconvertDOMtoCanvas(t.x),y:this._YconvertDOMtoCanvas(t.y)}}}]),t}();function Op(t,e){var i=At({nodes:e,minZoomLevel:Number.MIN_VALUE,maxZoomLevel:1},null!=t?t:{});if(!So(i.nodes))throw new TypeError("Nodes has to be an array of ids.");if(0===i.nodes.length&&(i.nodes=e),!("number"==typeof i.minZoomLevel&&i.minZoomLevel>0))throw new TypeError("Min zoom level has to be a number higher than zero.");if(!("number"==typeof i.maxZoomLevel&&i.minZoomLevel<=i.maxZoomLevel))throw new TypeError("Max zoom level has to be a number higher than min zoom level.");return i}var Cp=function(){function t(e,i){var n,o,r=this;Nn(this,t),this.body=e,this.canvas=i,this.animationSpeed=1/this.renderRefreshRate,this.animationEasingFunction="easeInOutQuint",this.easingTime=0,this.sourceScale=0,this.targetScale=0,this.sourceTranslation=0,this.targetTranslation=0,this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0,this.touchTime=0,this.viewFunction=void 0,this.body.emitter.on("fit",Vt(n=this.fit).call(n,this)),this.body.emitter.on("animationFinished",(function(){r.body.emitter.emit("_stopRendering")})),this.body.emitter.on("unlockNode",Vt(o=this.releaseNode).call(o,this))}return Fn(t,[{key:"setOptions",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};this.options=t}},{key:"fit",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];t=Op(t,this.body.nodeIndices);var i,n,o=this.canvas.frame.canvas.clientWidth,r=this.canvas.frame.canvas.clientHeight;if(0===o||0===r)n=1,i=pp.getRange(this.body.nodes,t.nodes);else if(!0===e){var s=0;for(var a in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,a)){var h=this.body.nodes[a];!0===h.predefinedPosition&&(s+=1)}if(s>.5*this.body.nodeIndices.length)return void this.fit(t,!1);i=pp.getRange(this.body.nodes,t.nodes);var l=this.body.nodeIndices.length;n=12.662/(l+7.4147)+.0964822;var d=Math.min(o/600,r/600);n*=d}else{this.body.emitter.emit("_resizeNodes"),i=pp.getRange(this.body.nodes,t.nodes);var c=1.1*Math.abs(i.maxX-i.minX),u=1.1*Math.abs(i.maxY-i.minY),f=o/c,p=r/u;n=f<=p?f:p}n>t.maxZoomLevel?n=t.maxZoomLevel:n<t.minZoomLevel&&(n=t.minZoomLevel);var v=pp.findCenter(i),g={position:v,scale:n,animation:t.animation};this.moveTo(g)}},{key:"focus",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(void 0!==this.body.nodes[t]){var i={x:this.body.nodes[t].x,y:this.body.nodes[t].y};e.position=i,e.lockedOnNode=t,this.moveTo(e)}else console.error("Node: "+t+" cannot be found.")}},{key:"moveTo",value:function(t){if(void 0!==t){if(null!=t.offset){if(null!=t.offset.x){if(t.offset.x=+t.offset.x,!wd(t.offset.x))throw new TypeError('The option "offset.x" has to be a finite number.')}else t.offset.x=0;if(null!=t.offset.y){if(t.offset.y=+t.offset.y,!wd(t.offset.y))throw new TypeError('The option "offset.y" has to be a finite number.')}else t.offset.x=0}else t.offset={x:0,y:0};if(null!=t.position){if(null!=t.position.x){if(t.position.x=+t.position.x,!wd(t.position.x))throw new TypeError('The option "position.x" has to be a finite number.')}else t.position.x=0;if(null!=t.position.y){if(t.position.y=+t.position.y,!wd(t.position.y))throw new TypeError('The option "position.y" has to be a finite number.')}else t.position.x=0}else t.position=this.getViewPosition();if(null!=t.scale){if(t.scale=+t.scale,!(t.scale>0))throw new TypeError('The option "scale" has to be a number greater than zero.')}else t.scale=this.body.view.scale;void 0===t.animation&&(t.animation={duration:0}),!1===t.animation&&(t.animation={duration:0}),!0===t.animation&&(t.animation={}),void 0===t.animation.duration&&(t.animation.duration=1e3),void 0===t.animation.easingFunction&&(t.animation.easingFunction="easeInOutQuad"),this.animateView(t)}else t={}}},{key:"animateView",value:function(t){if(void 0!==t){this.animationEasingFunction=t.animation.easingFunction,this.releaseNode(),!0===t.locked&&(this.lockedOnNodeId=t.lockedOnNode,this.lockedOnNodeOffset=t.offset),0!=this.easingTime&&this._transitionRedraw(!0),this.sourceScale=this.body.view.scale,this.sourceTranslation=this.body.view.translation,this.targetScale=t.scale,this.body.view.scale=this.targetScale;var e,i,n=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),o=n.x-t.position.x,r=n.y-t.position.y;if(this.targetTranslation={x:this.sourceTranslation.x+o*this.targetScale+t.offset.x,y:this.sourceTranslation.y+r*this.targetScale+t.offset.y},0===t.animation.duration)if(null!=this.lockedOnNodeId)this.viewFunction=Vt(e=this._lockedRedraw).call(e,this),this.body.emitter.on("initRedraw",this.viewFunction);else this.body.view.scale=this.targetScale,this.body.view.translation=this.targetTranslation,this.body.emitter.emit("_requestRedraw");else this.animationSpeed=1/(60*t.animation.duration*.001)||1/60,this.animationEasingFunction=t.animation.easingFunction,this.viewFunction=Vt(i=this._transitionRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction),this.body.emitter.emit("_startRendering")}}},{key:"_lockedRedraw",value:function(){var t=this.body.nodes[this.lockedOnNodeId].x,e=this.body.nodes[this.lockedOnNodeId].y,i=this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight}),n=i.x-t,o=i.y-e,r=this.body.view.translation,s={x:r.x+n*this.body.view.scale+this.lockedOnNodeOffset.x,y:r.y+o*this.body.view.scale+this.lockedOnNodeOffset.y};this.body.view.translation=s}},{key:"releaseNode",value:function(){void 0!==this.lockedOnNodeId&&void 0!==this.viewFunction&&(this.body.emitter.off("initRedraw",this.viewFunction),this.lockedOnNodeId=void 0,this.lockedOnNodeOffset=void 0)}},{key:"_transitionRedraw",value:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];this.easingTime+=this.animationSpeed,this.easingTime=!0===t?1:this.easingTime;var e=Zh[this.animationEasingFunction](this.easingTime);if(this.body.view.scale=this.sourceScale+(this.targetScale-this.sourceScale)*e,this.body.view.translation={x:this.sourceTranslation.x+(this.targetTranslation.x-this.sourceTranslation.x)*e,y:this.sourceTranslation.y+(this.targetTranslation.y-this.sourceTranslation.y)*e},this.easingTime>=1){var i;if(this.body.emitter.off("initRedraw",this.viewFunction),this.easingTime=0,null!=this.lockedOnNodeId)this.viewFunction=Vt(i=this._lockedRedraw).call(i,this),this.body.emitter.on("initRedraw",this.viewFunction);this.body.emitter.emit("animationFinished")}}},{key:"getScale",value:function(){return this.body.view.scale}},{key:"getViewPosition",value:function(){return this.canvas.DOMtoCanvas({x:.5*this.canvas.frame.canvas.clientWidth,y:.5*this.canvas.frame.canvas.clientHeight})}}]),t}();function Sp(t){var e,i=t&&t.preventDefault||!1,n=t&&t.container||window,o={},r={keydown:{},keyup:{}},s={};for(e=97;e<=122;e++)s[String.fromCharCode(e)]={code:e-97+65,shift:!1};for(e=65;e<=90;e++)s[String.fromCharCode(e)]={code:e,shift:!0};for(e=0;e<=9;e++)s[""+e]={code:48+e,shift:!1};for(e=1;e<=12;e++)s["F"+e]={code:111+e,shift:!1};for(e=0;e<=9;e++)s["num"+e]={code:96+e,shift:!1};s["num*"]={code:106,shift:!1},s["num+"]={code:107,shift:!1},s["num-"]={code:109,shift:!1},s["num/"]={code:111,shift:!1},s["num."]={code:110,shift:!1},s.left={code:37,shift:!1},s.up={code:38,shift:!1},s.right={code:39,shift:!1},s.down={code:40,shift:!1},s.space={code:32,shift:!1},s.enter={code:13,shift:!1},s.shift={code:16,shift:void 0},s.esc={code:27,shift:!1},s.backspace={code:8,shift:!1},s.tab={code:9,shift:!1},s.ctrl={code:17,shift:!1},s.alt={code:18,shift:!1},s.delete={code:46,shift:!1},s.pageup={code:33,shift:!1},s.pagedown={code:34,shift:!1},s["="]={code:187,shift:!1},s["-"]={code:189,shift:!1},s["]"]={code:221,shift:!1},s["["]={code:219,shift:!1};var a=function(t){l(t,"keydown")},h=function(t){l(t,"keyup")},l=function(t,e){if(void 0!==r[e][t.keyCode]){for(var n=r[e][t.keyCode],o=0;o<n.length;o++)(void 0===n[o].shift||1==n[o].shift&&1==t.shiftKey||0==n[o].shift&&0==t.shiftKey)&&n[o].fn(t);1==i&&t.preventDefault()}};return o.bind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);void 0===r[i][s[t].code]&&(r[i][s[t].code]=[]),r[i][s[t].code].push({fn:e,shift:s[t].shift})},o.bindAll=function(t,e){for(var i in void 0===e&&(e="keydown"),s)s.hasOwnProperty(i)&&o.bind(i,t,e)},o.getKey=function(t){for(var e in s)if(s.hasOwnProperty(e)){if(1==t.shiftKey&&1==s[e].shift&&t.keyCode==s[e].code)return e;if(0==t.shiftKey&&0==s[e].shift&&t.keyCode==s[e].code)return e;if(t.keyCode==s[e].code&&"shift"==e)return e}return"unknown key, currently not supported"},o.unbind=function(t,e,i){if(void 0===i&&(i="keydown"),void 0===s[t])throw new Error("unsupported key: "+t);if(void 0!==e){var n=[],o=r[i][s[t].code];if(void 0!==o)for(var a=0;a<o.length;a++)o[a].fn==e&&o[a].shift==s[t].shift||n.push(r[i][s[t].code][a]);r[i][s[t].code]=n}else r[i][s[t].code]=[]},o.reset=function(){r={keydown:{},keyup:{}}},o.destroy=function(){r={keydown:{},keyup:{}},n.removeEventListener("keydown",a,!0),n.removeEventListener("keyup",h,!0)},n.addEventListener("keydown",a,!0),n.addEventListener("keyup",h,!0),o}var Tp=Object.freeze({__proto__:null,default:Sp}),Mp=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this.iconsCreated=!1,this.navigationHammers=[],this.boundFunctions={},this.touchTime=0,this.activated=!1,this.body.emitter.on("activate",(function(){n.activated=!0,n.configureKeyboardBindings()})),this.body.emitter.on("deactivate",(function(){n.activated=!1,n.configureKeyboardBindings()})),this.body.emitter.on("destroy",(function(){void 0!==n.keycharm&&n.keycharm.destroy()})),this.options={}}return Fn(t,[{key:"setOptions",value:function(t){void 0!==t&&(this.options=t,this.create())}},{key:"create",value:function(){!0===this.options.navigationButtons?!1===this.iconsCreated&&this.loadNavigationElements():!0===this.iconsCreated&&this.cleanNavigation(),this.configureKeyboardBindings()}},{key:"cleanNavigation",value:function(){if(0!=this.navigationHammers.length){for(var t=0;t<this.navigationHammers.length;t++)this.navigationHammers[t].destroy();this.navigationHammers=[]}this.navigationDOM&&this.navigationDOM.wrapper&&this.navigationDOM.wrapper.parentNode&&this.navigationDOM.wrapper.parentNode.removeChild(this.navigationDOM.wrapper),this.iconsCreated=!1}},{key:"loadNavigationElements",value:function(){var t=this;this.cleanNavigation(),this.navigationDOM={};var e=["up","down","left","right","zoomIn","zoomOut","zoomExtends"],i=["_moveUp","_moveDown","_moveLeft","_moveRight","_zoomIn","_zoomOut","_fit"];this.navigationDOM.wrapper=document.createElement("div"),this.navigationDOM.wrapper.className="vis-navigation",this.canvas.frame.appendChild(this.navigationDOM.wrapper);for(var n=0;n<e.length;n++){this.navigationDOM[e[n]]=document.createElement("div"),this.navigationDOM[e[n]].className="vis-button vis-"+e[n],this.navigationDOM.wrapper.appendChild(this.navigationDOM[e[n]]);var o,r,s=new ll(this.navigationDOM[e[n]]);if("_fit"===i[n])_p(s,Vt(o=this._fit).call(o,this));else _p(s,Vt(r=this.bindToRedraw).call(r,this,i[n]));this.navigationHammers.push(s)}var a=new ll(this.canvas.frame);xp(a,(function(){t._stopMovement()})),this.navigationHammers.push(a),this.iconsCreated=!0}},{key:"bindToRedraw",value:function(t){var e;void 0===this.boundFunctions[t]&&(this.boundFunctions[t]=Vt(e=this[t]).call(e,this),this.body.emitter.on("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_startRendering"))}},{key:"unbindFromRedraw",value:function(t){void 0!==this.boundFunctions[t]&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"),delete this.boundFunctions[t])}},{key:"_fit",value:function(){(new Date).valueOf()-this.touchTime>700&&(this.body.emitter.emit("fit",{duration:700}),this.touchTime=(new Date).valueOf())}},{key:"_stopMovement",value:function(){for(var t in this.boundFunctions)Object.prototype.hasOwnProperty.call(this.boundFunctions,t)&&(this.body.emitter.off("initRedraw",this.boundFunctions[t]),this.body.emitter.emit("_stopRendering"));this.boundFunctions={}}},{key:"_moveUp",value:function(){this.body.view.translation.y+=this.options.keyboard.speed.y}},{key:"_moveDown",value:function(){this.body.view.translation.y-=this.options.keyboard.speed.y}},{key:"_moveLeft",value:function(){this.body.view.translation.x+=this.options.keyboard.speed.x}},{key:"_moveRight",value:function(){this.body.view.translation.x-=this.options.keyboard.speed.x}},{key:"_zoomIn",value:function(){var t=this.body.view.scale,e=this.body.view.scale*(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:null})}},{key:"_zoomOut",value:function(){var t=this.body.view.scale,e=this.body.view.scale/(1+this.options.keyboard.speed.zoom),i=this.body.view.translation,n=e/t,o=(1-n)*this.canvas.canvasViewCenter.x+i.x*n,r=(1-n)*this.canvas.canvasViewCenter.y+i.y*n;this.body.view.scale=e,this.body.view.translation={x:o,y:r},this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:null})}},{key:"configureKeyboardBindings",value:function(){var t,e,i,n,o,r,s,a,h,l,d,c,u,f,p,v,g,y,m,b,w,k,_,x,E=this;(void 0!==this.keycharm&&this.keycharm.destroy(),!0===this.options.keyboard.enabled)&&(!0===this.options.keyboard.bindToWindow?this.keycharm=Sp({container:window,preventDefault:!0}):this.keycharm=Sp({container:this.canvas.frame,preventDefault:!0}),this.keycharm.reset(),!0===this.activated&&(Vt(t=this.keycharm).call(t,"up",(function(){E.bindToRedraw("_moveUp")}),"keydown"),Vt(e=this.keycharm).call(e,"down",(function(){E.bindToRedraw("_moveDown")}),"keydown"),Vt(i=this.keycharm).call(i,"left",(function(){E.bindToRedraw("_moveLeft")}),"keydown"),Vt(n=this.keycharm).call(n,"right",(function(){E.bindToRedraw("_moveRight")}),"keydown"),Vt(o=this.keycharm).call(o,"=",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(r=this.keycharm).call(r,"num+",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(s=this.keycharm).call(s,"num-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(a=this.keycharm).call(a,"-",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(h=this.keycharm).call(h,"[",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(l=this.keycharm).call(l,"]",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(d=this.keycharm).call(d,"pageup",(function(){E.bindToRedraw("_zoomIn")}),"keydown"),Vt(c=this.keycharm).call(c,"pagedown",(function(){E.bindToRedraw("_zoomOut")}),"keydown"),Vt(u=this.keycharm).call(u,"up",(function(){E.unbindFromRedraw("_moveUp")}),"keyup"),Vt(f=this.keycharm).call(f,"down",(function(){E.unbindFromRedraw("_moveDown")}),"keyup"),Vt(p=this.keycharm).call(p,"left",(function(){E.unbindFromRedraw("_moveLeft")}),"keyup"),Vt(v=this.keycharm).call(v,"right",(function(){E.unbindFromRedraw("_moveRight")}),"keyup"),Vt(g=this.keycharm).call(g,"=",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(y=this.keycharm).call(y,"num+",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(m=this.keycharm).call(m,"num-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(b=this.keycharm).call(b,"-",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(w=this.keycharm).call(w,"[",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup"),Vt(k=this.keycharm).call(k,"]",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(_=this.keycharm).call(_,"pageup",(function(){E.unbindFromRedraw("_zoomIn")}),"keyup"),Vt(x=this.keycharm).call(x,"pagedown",(function(){E.unbindFromRedraw("_zoomOut")}),"keyup")))}}]),t}();function Pp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Dp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Dp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Dp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ip=function(){function t(e,i,n){var o,r,s,a,h,l,d,c,u,f,p,v,g;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.navigationHandler=new Mp(e,i),this.body.eventListeners.onTap=Vt(o=this.onTap).call(o,this),this.body.eventListeners.onTouch=Vt(r=this.onTouch).call(r,this),this.body.eventListeners.onDoubleTap=Vt(s=this.onDoubleTap).call(s,this),this.body.eventListeners.onHold=Vt(a=this.onHold).call(a,this),this.body.eventListeners.onDragStart=Vt(h=this.onDragStart).call(h,this),this.body.eventListeners.onDrag=Vt(l=this.onDrag).call(l,this),this.body.eventListeners.onDragEnd=Vt(d=this.onDragEnd).call(d,this),this.body.eventListeners.onMouseWheel=Vt(c=this.onMouseWheel).call(c,this),this.body.eventListeners.onPinch=Vt(u=this.onPinch).call(u,this),this.body.eventListeners.onMouseMove=Vt(f=this.onMouseMove).call(f,this),this.body.eventListeners.onRelease=Vt(p=this.onRelease).call(p,this),this.body.eventListeners.onContext=Vt(v=this.onContext).call(v,this),this.touchTime=0,this.drag={},this.pinch={},this.popup=void 0,this.popupObj=void 0,this.popupTimer=void 0,this.body.functions.getPointer=Vt(g=this.getPointer).call(g,this),this.options={},this.defaultOptions={dragNodes:!0,dragView:!0,hover:!1,keyboard:{enabled:!1,speed:{x:10,y:10,zoom:.02},bindToWindow:!0,autoFocus:!0},navigationButtons:!1,tooltipDelay:300,zoomView:!0,zoomSpeed:1},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("destroy",(function(){clearTimeout(t.popupTimer),delete t.body.functions.getPointer}))}},{key:"setOptions",value:function(t){if(void 0!==t){Oh(["hideEdgesOnDrag","hideEdgesOnZoom","hideNodesOnDrag","keyboard","multiselect","selectable","selectConnectedEdges"],this.options,t),$h(this.options,t,"keyboard"),t.tooltip&&(At(this.options.tooltip,t.tooltip),t.tooltip.color&&(this.options.tooltip.color=Rh(t.tooltip.color)))}this.navigationHandler.setOptions(this.options)}},{key:"getPointer",value:function(t){return{x:t.x-Mh(this.canvas.frame.canvas),y:t.y-Ph(this.canvas.frame.canvas)}}},{key:"onTouch",value:function(t){(new Date).valueOf()-this.touchTime>50&&(this.drag.pointer=this.getPointer(t.center),this.drag.pinched=!1,this.pinch.scale=this.body.view.scale,this.touchTime=(new Date).valueOf())}},{key:"onTap",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect&&(t.changedPointers[0].ctrlKey||t.changedPointers[0].metaKey);this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e)}},{key:"onDoubleTap",value:function(t){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("doubleClick",t,e)}},{key:"onHold",value:function(t){var e=this.getPointer(t.center),i=this.selectionHandler.options.multiselect;this.checkSelectionChanges(e,i),this.selectionHandler.commitAndEmit(e,t),this.selectionHandler.generateClickEvent("click",t,e),this.selectionHandler.generateClickEvent("hold",t,e)}},{key:"onRelease",value:function(t){if((new Date).valueOf()-this.touchTime>10){var e=this.getPointer(t.center);this.selectionHandler.generateClickEvent("release",t,e),this.touchTime=(new Date).valueOf()}}},{key:"onContext",value:function(t){var e=this.getPointer({x:t.clientX,y:t.clientY});this.selectionHandler.generateClickEvent("oncontext",t,e)}},{key:"checkSelectionChanges",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]&&arguments[1];!0===e?this.selectionHandler.selectAdditionalOnPoint(t):this.selectionHandler.selectOnPoint(t)}},{key:"_determineDifference",value:function(t,e){var i=function(t,e){for(var i=[],n=0;n<t.length;n++){var o=t[n];-1===Hr(e).call(e,o)&&i.push(o)}return i};return{nodes:i(t.nodes,e.nodes),edges:i(t.edges,e.edges)}}},{key:"onDragStart",value:function(t){if(!this.drag.dragging){void 0===this.drag.pointer&&this.onTouch(t);var e=this.selectionHandler.getNodeAt(this.drag.pointer);if(this.drag.dragging=!0,this.drag.selection=[],this.drag.translation=At({},this.body.view.translation),this.drag.nodeId=void 0,t.srcEvent.shiftKey){this.body.selectionBox.show=!0;var i=this.getPointer(t.center);this.body.selectionBox.position.start={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)}}if(void 0!==e&&!0===this.options.dragNodes){this.drag.nodeId=e.id,!1===e.isSelected()&&(this.selectionHandler.unselectAll(),this.selectionHandler.selectObject(e)),this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer);var n,o=Pp(this.selectionHandler.getSelectedNodes());try{for(o.s();!(n=o.n()).done;){var r=n.value,s={id:r.id,node:r,x:r.x,y:r.y,xFixed:r.options.fixed.x,yFixed:r.options.fixed.y};r.options.fixed.x=!0,r.options.fixed.y=!0,this.drag.selection.push(s)}}catch(t){o.e(t)}finally{o.f()}}else this.selectionHandler.generateClickEvent("dragStart",t,this.drag.pointer,void 0,!0)}}},{key:"onDrag",value:function(t){var e=this;if(!0!==this.drag.pinched){this.body.emitter.emit("unlockNode");var i=this.getPointer(t.center),n=this.drag.selection;if(n&&n.length&&!0===this.options.dragNodes){this.selectionHandler.generateClickEvent("dragging",t,i);var o=i.x-this.drag.pointer.x,r=i.y-this.drag.pointer.y;Wo(n).call(n,(function(t){var i=t.node;!1===t.xFixed&&(i.x=e.canvas._XconvertDOMtoCanvas(e.canvas._XconvertCanvasToDOM(t.x)+o)),!1===t.yFixed&&(i.y=e.canvas._YconvertDOMtoCanvas(e.canvas._YconvertCanvasToDOM(t.y)+r))})),this.body.emitter.emit("startSimulation")}else{if(t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);this.body.selectionBox.position.end={x:this.canvas._XconvertDOMtoCanvas(i.x),y:this.canvas._YconvertDOMtoCanvas(i.y)},this.body.emitter.emit("_requestRedraw")}if(!0===this.options.dragView&&!t.srcEvent.shiftKey){if(this.selectionHandler.generateClickEvent("dragging",t,i,void 0,!0),void 0===this.drag.pointer)return void this.onDragStart(t);var s=i.x-this.drag.pointer.x,a=i.y-this.drag.pointer.y;this.body.view.translation={x:this.drag.translation.x+s,y:this.drag.translation.y+a},this.body.emitter.emit("_requestRedraw")}}}}},{key:"onDragEnd",value:function(t){var e=this;if(this.drag.dragging=!1,this.body.selectionBox.show){var i;this.body.selectionBox.show=!1;var n=this.body.selectionBox.position,o={minX:Math.min(n.start.x,n.end.x),minY:Math.min(n.start.y,n.end.y),maxX:Math.max(n.start.x,n.end.x),maxY:Math.max(n.start.y,n.end.y)},r=mr(i=this.body.nodeIndices).call(i,(function(t){var i=e.body.nodes[t];return i.x>=o.minX&&i.x<=o.maxX&&i.y>=o.minY&&i.y<=o.maxY}));Wo(r).call(r,(function(t){return e.selectionHandler.selectObject(e.body.nodes[t])}));var s=this.getPointer(t.center);this.selectionHandler.commitAndEmit(s,t),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw")}else{var a=this.drag.selection;a&&a.length?(Wo(a).call(a,(function(t){t.node.options.fixed.x=t.xFixed,t.node.options.fixed.y=t.yFixed})),this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center)),this.body.emitter.emit("startSimulation")):(this.selectionHandler.generateClickEvent("dragEnd",t,this.getPointer(t.center),void 0,!0),this.body.emitter.emit("_requestRedraw"))}}},{key:"onPinch",value:function(t){var e=this.getPointer(t.center);this.drag.pinched=!0,void 0===this.pinch.scale&&(this.pinch.scale=1);var i=this.pinch.scale*t.scale;this.zoom(i,e)}},{key:"zoom",value:function(t,e){if(!0===this.options.zoomView){var i=this.body.view.scale;t<1e-5&&(t=1e-5),t>10&&(t=10);var n=void 0;void 0!==this.drag&&!0===this.drag.dragging&&(n=this.canvas.DOMtoCanvas(this.drag.pointer));var o=this.body.view.translation,r=t/i,s=(1-r)*e.x+o.x*r,a=(1-r)*e.y+o.y*r;if(this.body.view.scale=t,this.body.view.translation={x:s,y:a},null!=n){var h=this.canvas.canvasToDOM(n);this.drag.pointer.x=h.x,this.drag.pointer.y=h.y}this.body.emitter.emit("_requestRedraw"),i<t?this.body.emitter.emit("zoom",{direction:"+",scale:this.body.view.scale,pointer:e}):this.body.emitter.emit("zoom",{direction:"-",scale:this.body.view.scale,pointer:e})}}},{key:"onMouseWheel",value:function(t){if(!0===this.options.zoomView){if(0!==t.deltaY){var e=this.body.view.scale;e*=1+(t.deltaY<0?1:-1)*(.1*this.options.zoomSpeed);var i=this.getPointer({x:t.clientX,y:t.clientY});this.zoom(e,i)}t.preventDefault()}}},{key:"onMouseMove",value:function(t){var e=this,i=this.getPointer({x:t.clientX,y:t.clientY}),n=!1;void 0!==this.popup&&(!1===this.popup.hidden&&this._checkHidePopup(i),!1===this.popup.hidden&&(n=!0,this.popup.setPosition(i.x+3,i.y-5),this.popup.show())),this.options.keyboard.autoFocus&&!1===this.options.keyboard.bindToWindow&&!0===this.options.keyboard.enabled&&this.canvas.frame.focus(),!1===n&&(void 0!==this.popupTimer&&(clearInterval(this.popupTimer),this.popupTimer=void 0),this.drag.dragging||(this.popupTimer=rs((function(){return e._checkShowPopup(i)}),this.options.tooltipDelay))),!0===this.options.hover&&this.selectionHandler.hoverObject(t,i)}},{key:"_checkShowPopup",value:function(t){var e=this.canvas._XconvertDOMtoCanvas(t.x),i=this.canvas._YconvertDOMtoCanvas(t.y),n={left:e,top:i,right:e,bottom:i},o=void 0===this.popupObj?void 0:this.popupObj.id,r=!1,s="node";if(void 0===this.popupObj){for(var a,h=this.body.nodeIndices,l=this.body.nodes,d=[],c=0;c<h.length;c++)!0===(a=l[h[c]]).isOverlappingWith(n)&&(r=!0,void 0!==a.getTitle()&&d.push(h[c]));d.length>0&&(this.popupObj=l[d[d.length-1]],r=!0)}if(void 0===this.popupObj&&!1===r){for(var u,f=this.body.edgeIndices,p=this.body.edges,v=[],g=0;g<f.length;g++)!0===(u=p[f[g]]).isOverlappingWith(n)&&!0===u.connected&&void 0!==u.getTitle()&&v.push(f[g]);v.length>0&&(this.popupObj=p[v[v.length-1]],s="edge")}void 0!==this.popupObj?this.popupObj.id!==o&&(void 0===this.popup&&(this.popup=new dl(this.canvas.frame)),this.popup.popupTargetType=s,this.popup.popupTargetId=this.popupObj.id,this.popup.setPosition(t.x+3,t.y-5),this.popup.setText(this.popupObj.getTitle()),this.popup.show(),this.body.emitter.emit("showPopup",this.popupObj.id)):void 0!==this.popup&&(this.popup.hide(),this.body.emitter.emit("hidePopup"))}},{key:"_checkHidePopup",value:function(t){var e=this.selectionHandler._pointerToPositionObject(t),i=!1;if("node"===this.popup.popupTargetType){if(void 0!==this.body.nodes[this.popup.popupTargetId]&&!0===(i=this.body.nodes[this.popup.popupTargetId].isOverlappingWith(e))){var n=this.selectionHandler.getNodeAt(t);i=void 0!==n&&n.id===this.popup.popupTargetId}}else void 0===this.selectionHandler.getNodeAt(t)&&void 0!==this.body.edges[this.popup.popupTargetId]&&(i=this.body.edges[this.popup.popupTargetId].isOverlappingWith(e));!1===i&&(this.popupObj=void 0,this.popup.hide(),this.body.emitter.emit("hidePopup"))}}]),t}(),Bp=Jl.getWeakData,zp=we.set,Np=we.getterFor,Ap=Gi.find,Fp=Gi.findIndex,jp=0,Rp=function(t){return t.frozen||(t.frozen=new Lp)},Lp=function(){this.entries=[]},Hp=function(t,e){return Ap(t.entries,(function(t){return t[0]===e}))};Lp.prototype={get:function(t){var e=Hp(this,t);if(e)return e[1]},has:function(t){return!!Hp(this,t)},set:function(t,e){var i=Hp(this,t);i?i[1]=e:this.entries.push([t,e])},delete:function(t){var e=Fp(this.entries,(function(e){return e[0]===t}));return~e&&this.entries.splice(e,1),!!~e}};var Wp={getConstructor:function(t,e,i,n){var o=t((function(t,r){id(t,o,e),zp(t,{type:e,id:jp++,frozen:void 0}),null!=r&&ed(r,t[n],{that:t,AS_ENTRIES:i})})),r=Np(e),s=function(t,e,i){var n=r(t),o=Bp(dt(e),!0);return!0===o?Rp(n).set(e,i):o[n.id]=i,t};return hd(o.prototype,{delete:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).delete(t):i&&j(i,e.id)&&delete i[e.id]},has:function(t){var e=r(this);if(!w(t))return!1;var i=Bp(t);return!0===i?Rp(e).has(t):i&&j(i,e.id)}}),hd(o.prototype,i?{get:function(t){var e=r(this);if(w(t)){var i=Bp(t);return!0===i?Rp(e).get(t):i?i[e.id]:void 0}},set:function(t,e){return s(this,t,e)}}:{add:function(t){return s(this,t,!0)}}),o}};n((function(t){var e,i=we.enforce,n=!a.ActiveXObject&&"ActiveXObject"in a,o=Object.isExtensible,r=function(t){return function(){return t(this,arguments.length?arguments[0]:void 0)}},s=t.exports=ad("WeakMap",r,Wp);if(ae&&n){e=Wp.getConstructor(r,"WeakMap",!0),Jl.enable();var h=s.prototype,l=h.delete,d=h.has,c=h.get,u=h.set;hd(h,{delete:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),l.call(this,t)||n.frozen.delete(t)}return l.call(this,t)},has:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)||n.frozen.has(t)}return d.call(this,t)},get:function(t){if(w(t)&&!o(t)){var n=i(this);return n.frozen||(n.frozen=new e),d.call(this,t)?c.call(this,t):n.frozen.get(t)}return c.call(this,t)},set:function(t,n){if(w(t)&&!o(t)){var r=i(this);r.frozen||(r.frozen=new e),d.call(this,t)?u.call(this,t,n):r.frozen.set(t,n)}else u.call(this,t,n);return this}})}}));var qp,Vp,Up,Yp,Xp,Gp=k.WeakMap;function Kp(t,e,i,n){if("a"===i&&!n)throw new TypeError("Private accessor was defined without a getter");if("function"==typeof e?t!==e||!n:!e.has(t))throw new TypeError("Cannot read private member from an object whose class did not declare it");return"m"===i?n:"a"===i?n.call(t):n?n.value:e.get(t)}function $p(t,e,i,n,o){if("m"===n)throw new TypeError("Private method is not writable");if("a"===n&&!o)throw new TypeError("Private accessor was defined without a setter");if("function"==typeof e?t!==e||!o:!e.has(t))throw new TypeError("Cannot write private member to an object whose class did not declare it");return"a"===n?o.call(t,i):o?o.value=i:e.set(t,i),i}function Zp(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Qp(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Qp(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Qp(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function Jp(t,e){var i,n=new ec,o=Zp(e);try{for(o.s();!(i=o.n()).done;){var r=i.value;t.has(r)||n.add(r)}}catch(t){o.e(t)}finally{o.f()}return n}var tv=function(){function t(){Nn(this,t),qp.set(this,new ec),Vp.set(this,new ec)}return Fn(t,[{key:"size",get:function(){return Kp(this,Vp,"f").size}},{key:"add",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").add(r)}}},{key:"delete",value:function(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];for(var n=0,o=e;n<o.length;n++){var r=o[n];Kp(this,Vp,"f").delete(r)}}},{key:"clear",value:function(){Kp(this,Vp,"f").clear()}},{key:"getSelection",value:function(){return wo(Kp(this,Vp,"f"))}},{key:"getChanges",value:function(){return{added:wo(Jp(Kp(this,qp,"f"),Kp(this,Vp,"f"))),deleted:wo(Jp(Kp(this,Vp,"f"),Kp(this,qp,"f"))),previous:wo(new ec(Kp(this,qp,"f"))),current:wo(new ec(Kp(this,Vp,"f")))}}},{key:"commit",value:function(){var t=this.getChanges();$p(this,qp,Kp(this,Vp,"f"),"f"),$p(this,Vp,new ec(Kp(this,qp,"f")),"f");var e,i=Zp(t.added);try{for(i.s();!(e=i.n()).done;){e.value.select()}}catch(t){i.e(t)}finally{i.f()}var n,o=Zp(t.deleted);try{for(o.s();!(n=o.n()).done;){n.value.unselect()}}catch(t){o.e(t)}finally{o.f()}return t}}]),t}();qp=new Gp,Vp=new Gp;var ev=function(){function t(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){};Nn(this,t),Up.set(this,new tv),Yp.set(this,new tv),Xp.set(this,void 0),$p(this,Xp,e,"f")}return Fn(t,[{key:"sizeNodes",get:function(){return Kp(this,Up,"f").size}},{key:"sizeEdges",get:function(){return Kp(this,Yp,"f").size}},{key:"getNodes",value:function(){return Kp(this,Up,"f").getSelection()}},{key:"getEdges",value:function(){return Kp(this,Yp,"f").getSelection()}},{key:"addNodes",value:function(){var t;(t=Kp(this,Up,"f")).add.apply(t,arguments)}},{key:"addEdges",value:function(){var t;(t=Kp(this,Yp,"f")).add.apply(t,arguments)}},{key:"deleteNodes",value:function(t){Kp(this,Up,"f").delete(t)}},{key:"deleteEdges",value:function(t){Kp(this,Yp,"f").delete(t)}},{key:"clear",value:function(){Kp(this,Up,"f").clear(),Kp(this,Yp,"f").clear()}},{key:"commit",value:function(){for(var t,e,i={nodes:Kp(this,Up,"f").commit(),edges:Kp(this,Yp,"f").commit()},n=arguments.length,o=new Array(n),r=0;r<n;r++)o[r]=arguments[r];return(t=Kp(this,Xp,"f")).call.apply(t,Eo(e=[this,i]).call(e,o)),i}}]),t}();function iv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return nv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return nv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function nv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}Up=new Gp,Yp=new Gp,Xp=new Gp;var ov=function(){function t(e,i){var n=this;Nn(this,t),this.body=e,this.canvas=i,this._selectionAccumulator=new ev,this.hoverObj={nodes:{},edges:{}},this.options={},this.defaultOptions={multiselect:!1,selectable:!0,selectConnectedEdges:!0,hoverConnectedEdges:!0},At(this.options,this.defaultOptions),this.body.emitter.on("_dataChanged",(function(){n.updateSelection()}))}return Fn(t,[{key:"setOptions",value:function(t){if(void 0!==t){Eh(["multiselect","hoverConnectedEdges","selectable","selectConnectedEdges"],this.options,t)}}},{key:"selectOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);this.unselectAll(),void 0!==i&&(e=this.selectObject(i)),this.body.emitter.emit("_requestRedraw")}return e}},{key:"selectAdditionalOnPoint",value:function(t){var e=!1;if(!0===this.options.selectable){var i=this.getNodeAt(t)||this.getEdgeAt(t);void 0!==i&&(e=!0,!0===i.isSelected()?this.deselectObject(i):this.selectObject(i),this.body.emitter.emit("_requestRedraw"))}return e}},{key:"_initBaseEvent",value:function(t,e){var i={};return i.pointer={DOM:{x:e.x,y:e.y},canvas:this.canvas.DOMtoCanvas(e)},i.event=t,i}},{key:"generateClickEvent",value:function(t,e,i,n){var o=arguments.length>4&&void 0!==arguments[4]&&arguments[4],r=this._initBaseEvent(e,i);if(!0===o)r.nodes=[],r.edges=[];else{var s=this.getSelection();r.nodes=s.nodes,r.edges=s.edges}void 0!==n&&(r.previousSelection=n),"click"==t&&(r.items=this.getClickedItems(i)),void 0!==e.controlEdge&&(r.controlEdge=e.controlEdge),this.body.emitter.emit(t,r)}},{key:"selectObject",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:this.options.selectConnectedEdges;if(void 0!==t){if(t instanceof cf){var i;if(!0===e)(i=this._selectionAccumulator).addEdges.apply(i,wo(t.edges));this._selectionAccumulator.addNodes(t)}else this._selectionAccumulator.addEdges(t);return!0}return!1}},{key:"deselectObject",value:function(t){!0===t.isSelected()&&(t.selected=!1,this._removeFromSelection(t))}},{key:"_getAllNodesOverlappingWith",value:function(t){for(var e=[],i=this.body.nodes,n=0;n<this.body.nodeIndices.length;n++){var o=this.body.nodeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}return e}},{key:"_pointerToPositionObject",value:function(t){var e=this.canvas.DOMtoCanvas(t);return{left:e.x-1,top:e.y+1,right:e.x+1,bottom:e.y-1}}},{key:"getNodeAt",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this._pointerToPositionObject(t),n=this._getAllNodesOverlappingWith(i);return n.length>0?!0===e?this.body.nodes[n[n.length-1]]:n[n.length-1]:void 0}},{key:"_getEdgesOverlappingWith",value:function(t,e){for(var i=this.body.edges,n=0;n<this.body.edgeIndices.length;n++){var o=this.body.edgeIndices[n];i[o].isOverlappingWith(t)&&e.push(o)}}},{key:"_getAllEdgesOverlappingWith",value:function(t){var e=[];return this._getEdgesOverlappingWith(t,e),e}},{key:"getEdgeAt",value:function(t){for(var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],i=this.canvas.DOMtoCanvas(t),n=10,o=null,r=this.body.edges,s=0;s<this.body.edgeIndices.length;s++){var a=this.body.edgeIndices[s],h=r[a];if(h.connected){var l=h.from.x,d=h.from.y,c=h.to.x,u=h.to.y,f=h.edgeType.getDistanceToEdge(l,d,c,u,i.x,i.y);f<n&&(o=a,n=f)}}return null!==o?!0===e?this.body.edges[o]:o:void 0}},{key:"_addToHover",value:function(t){t instanceof cf?this.hoverObj.nodes[t.id]=t:this.hoverObj.edges[t.id]=t}},{key:"_removeFromSelection",value:function(t){var e;t instanceof cf?(this._selectionAccumulator.deleteNodes(t),(e=this._selectionAccumulator).deleteEdges.apply(e,wo(t.edges))):this._selectionAccumulator.deleteEdges(t)}},{key:"unselectAll",value:function(){this._selectionAccumulator.clear()}},{key:"getSelectedNodeCount",value:function(){return this._selectionAccumulator.sizeNodes}},{key:"getSelectedEdgeCount",value:function(){return this._selectionAccumulator.sizeEdges}},{key:"_hoverConnectedEdges",value:function(t){for(var e=0;e<t.edges.length;e++){var i=t.edges[e];i.hover=!0,this._addToHover(i)}}},{key:"emitBlurEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e);!0===i.hover&&(i.hover=!1,i instanceof cf?(n.node=i.id,this.body.emitter.emit("blurNode",n)):(n.edge=i.id,this.body.emitter.emit("blurEdge",n)))}},{key:"emitHoverEvent",value:function(t,e,i){var n=this._initBaseEvent(t,e),o=!1;return!1===i.hover&&(i.hover=!0,this._addToHover(i),o=!0,i instanceof cf?(n.node=i.id,this.body.emitter.emit("hoverNode",n)):(n.edge=i.id,this.body.emitter.emit("hoverEdge",n))),o}},{key:"hoverObject",value:function(t,e){var i=this.getNodeAt(e);void 0===i&&(i=this.getEdgeAt(e));var n=!1;for(var o in this.hoverObj.nodes)Object.prototype.hasOwnProperty.call(this.hoverObj.nodes,o)&&(void 0===i||i instanceof cf&&i.id!=o||i instanceof ep)&&(this.emitBlurEvent(t,e,this.hoverObj.nodes[o]),delete this.hoverObj.nodes[o],n=!0);for(var r in this.hoverObj.edges)Object.prototype.hasOwnProperty.call(this.hoverObj.edges,r)&&(!0===n?(this.hoverObj.edges[r].hover=!1,delete this.hoverObj.edges[r]):(void 0===i||i instanceof ep&&i.id!=r||i instanceof cf&&!i.hover)&&(this.emitBlurEvent(t,e,this.hoverObj.edges[r]),delete this.hoverObj.edges[r],n=!0));if(void 0!==i){var s=zo(this.hoverObj.edges).length,a=zo(this.hoverObj.nodes).length;(n||i instanceof ep&&0===s&&0===a||i instanceof cf&&0===s&&0===a)&&(n=this.emitHoverEvent(t,e,i)),i instanceof cf&&!0===this.options.hoverConnectedEdges&&this._hoverConnectedEdges(i)}!0===n&&this.body.emitter.emit("_requestRedraw")}},{key:"commitWithoutEmitting",value:function(){this._selectionAccumulator.commit()}},{key:"commitAndEmit",value:function(t,e){var i=!1,n=this._selectionAccumulator.commit(),o={nodes:n.nodes.previous,edges:n.edges.previous};n.edges.deleted.length>0&&(this.generateClickEvent("deselectEdge",e,t,o),i=!0),n.nodes.deleted.length>0&&(this.generateClickEvent("deselectNode",e,t,o),i=!0),n.nodes.added.length>0&&(this.generateClickEvent("selectNode",e,t),i=!0),n.edges.added.length>0&&(this.generateClickEvent("selectEdge",e,t),i=!0),!0===i&&this.generateClickEvent("select",e,t)}},{key:"getSelection",value:function(){return{nodes:this.getSelectedNodeIds(),edges:this.getSelectedEdgeIds()}}},{key:"getSelectedNodes",value:function(){return this._selectionAccumulator.getNodes()}},{key:"getSelectedEdges",value:function(){return this._selectionAccumulator.getEdges()}},{key:"getSelectedNodeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getNodes()).call(t,(function(t){return t.id}))}},{key:"getSelectedEdgeIds",value:function(){var t;return Io(t=this._selectionAccumulator.getEdges()).call(t,(function(t){return t.id}))}},{key:"setSelection",value:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{};if(!t||!t.nodes&&!t.edges)throw new TypeError("Selection must be an object with nodes and/or edges properties");if((e.unselectAll||void 0===e.unselectAll)&&this.unselectAll(),t.nodes){var i,n=iv(t.nodes);try{for(n.s();!(i=n.n()).done;){var o=i.value,r=this.body.nodes[o];if(!r)throw new RangeError('Node with id "'+o+'" not found');this.selectObject(r,e.highlightEdges)}}catch(t){n.e(t)}finally{n.f()}}if(t.edges){var s,a=iv(t.edges);try{for(a.s();!(s=a.n()).done;){var h=s.value,l=this.body.edges[h];if(!l)throw new RangeError('Edge with id "'+h+'" not found');this.selectObject(l)}}catch(t){a.e(t)}finally{a.f()}}this.body.emitter.emit("_requestRedraw"),this._selectionAccumulator.commit()}},{key:"selectNodes",value:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1];if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({nodes:t},{highlightEdges:e})}},{key:"selectEdges",value:function(t){if(!t||void 0===t.length)throw"Selection must be an array with ids";this.setSelection({edges:t})}},{key:"updateSelection",value:function(){for(var t in this._selectionAccumulator.getNodes())Object.prototype.hasOwnProperty.call(this.body.nodes,t.id)||this._selectionAccumulator.deleteNodes(t);for(var e in this._selectionAccumulator.getEdges())Object.prototype.hasOwnProperty.call(this.body.edges,e.id)||this._selectionAccumulator.deleteEdges(e)}},{key:"getClickedItems",value:function(t){for(var e=this.canvas.DOMtoCanvas(t),i=[],n=this.body.nodeIndices,o=this.body.nodes,r=n.length-1;r>=0;r--){var s=o[n[r]].getItemsOnPoint(e);i.push.apply(i,s)}for(var a=this.body.edgeIndices,h=this.body.edges,l=a.length-1;l>=0;l--){var d=h[a[l]].getItemsOnPoint(e);i.push.apply(i,d)}return i}}]),t}(),rv=n((function(t,e){!function(t){function e(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}t.__esModule=!0,t.sort=v;var i=32,n=7,o=256,r=[1,10,100,1e3,1e4,1e5,1e6,1e7,1e8,1e9];function s(t){return t<1e5?t<100?t<10?0:1:t<1e4?t<1e3?2:3:4:t<1e7?t<1e6?5:6:t<1e9?t<1e8?7:8:9}function a(t,e){if(t===e)return 0;if(~~t===t&&~~e===e){if(0===t||0===e)return t<e?-1:1;if(t<0||e<0){if(e>=0)return-1;if(t>=0)return 1;t=-t,e=-e}var i=s(t),n=s(e),o=0;return i<n?(t*=r[n-i-1],e/=10,o=-1):i>n&&(e*=r[i-n-1],t/=10,o=1),t===e?o:t<e?-1:1}var a=String(t),h=String(e);return a===h?0:a<h?-1:1}function h(t){for(var e=0;t>=i;)e|=1&t,t>>=1;return t+e}function l(t,e,i,n){var o=e+1;if(o===i)return 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d=s+(h-s>>>1);r(t,e[i+d])<0?h=d:s=d+1}return h}var p=function(){function t(i,r){e(this,t),this.array=null,this.compare=null,this.minGallop=n,this.length=0,this.tmpStorageLength=o,this.stackLength=0,this.runStart=null,this.runLength=null,this.stackSize=0,this.array=i,this.compare=r,this.length=i.length,this.length<2*o&&(this.tmpStorageLength=this.length>>>1),this.tmp=new Array(this.tmpStorageLength),this.stackLength=this.length<120?5:this.length<1542?10:this.length<119151?19:40,this.runStart=new Array(this.stackLength),this.runLength=new Array(this.stackLength)}return t.prototype.pushRun=function(t,e){this.runStart[this.stackSize]=t,this.runLength[this.stackSize]=e,this.stackSize+=1},t.prototype.mergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;if(t>=1&&this.runLength[t-1]<=this.runLength[t]+this.runLength[t+1]||t>=2&&this.runLength[t-2]<=this.runLength[t]+this.runLength[t-1])this.runLength[t-1]<this.runLength[t+1]&&t--;else if(this.runLength[t]>this.runLength[t+1])break;this.mergeAt(t)}},t.prototype.forceMergeRuns=function(){for(;this.stackSize>1;){var t=this.stackSize-2;t>0&&this.runLength[t-1]<this.runLength[t+1]&&t--,this.mergeAt(t)}},t.prototype.mergeAt=function(t){var e=this.compare,i=this.array,n=this.runStart[t],o=this.runLength[t],r=this.runStart[t+1],s=this.runLength[t+1];this.runLength[t]=o+s,t===this.stackSize-3&&(this.runStart[t+1]=this.runStart[t+2],this.runLength[t+1]=this.runLength[t+2]),this.stackSize--;var a=f(i[r],i,n,o,0,e);n+=a,0!=(o-=a)&&0!==(s=u(i[n+o-1],i,r,s,s-1,e))&&(o<=s?this.mergeLow(n,o,r,s):this.mergeHigh(n,o,r,s))},t.prototype.mergeLow=function(t,e,i,o){var r=this.compare,s=this.array,a=this.tmp,h=0;for(h=0;h<e;h++)a[h]=s[t+h];var l=0,d=i,c=t;if(s[c++]=s[d++],0!=--o)if(1!==e){for(var p=this.minGallop;;){var v=0,g=0,y=!1;do{if(r(s[d],a[l])<0){if(s[c++]=s[d++],g++,v=0,0==--o){y=!0;break}}else 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if(s[c--]=a[d--],m++,y=0,1==--o){b=!0;break}}while((y|m)<g);if(b)break;do{if(0!=(y=e-f(a[d],s,t,e,e-1,r))){for(e-=y,v=1+(c-=y),p=1+(l-=y),h=y-1;h>=0;h--)s[v+h]=s[p+h];if(0===e){b=!0;break}}if(s[c--]=a[d--],1==--o){b=!0;break}if(0!=(m=o-u(s[l],a,0,o,o-1,r))){for(o-=m,v=1+(c-=m),p=1+(d-=m),h=0;h<m;h++)s[v+h]=a[p+h];if(o<=1){b=!0;break}}if(s[c--]=s[l--],0==--e){b=!0;break}g--}while(y>=n||m>=n);if(b)break;g<0&&(g=0),g+=2}if(this.minGallop=g,g<1&&(this.minGallop=1),1===o){for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else{if(0===o)throw new Error("mergeHigh preconditions were not respected");for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]}}else{for(v=1+(c-=e),p=1+(l-=e),h=e-1;h>=0;h--)s[v+h]=s[p+h];s[c]=a[d]}else for(p=c-(o-1),h=0;h<o;h++)s[p+h]=a[h]},t}();function v(t,e,n,o){if(!Array.isArray(t))throw new TypeError("Can only sort arrays");e?"function"!=typeof e&&(o=n,n=e,e=a):e=a,n||(n=0),o||(o=t.length);var r=o-n;if(!(r<2)){var s=0;if(r<i)c(t,n,o,n+(s=l(t,n,o,e)),e);else{var d=new p(t,e),u=h(r);do{if((s=l(t,n,o,e))<u){var f=r;f>u&&(f=u),c(t,n,n+f,n+s,e),s=f}d.pushRun(n,s),d.mergeRuns(),r-=s,n+=s}while(0!==r);d.forceMergeRuns()}}}}(e)}));i(rv);var sv=rv,av=sv.sort;function hv(t){var e=function(){if("undefined"==typeof Reflect||!Pd)return!1;if(Pd.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Pd(Boolean,[],(function(){}))),!0}catch(t){return!1}}();return function(){var i,n=Ld(t);if(e){var o=Ld(this).constructor;i=Pd(n,arguments,o)}else i=n.apply(this,arguments);return Fd(this,i)}}var lv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"abstract",value:function(){throw new Error("Can't instantiate abstract class!")}},{key:"fake_use",value:function(){}},{key:"curveType",value:function(){return this.abstract()}},{key:"getPosition",value:function(t){return this.fake_use(t),this.abstract()}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;this.fake_use(t,e,i),this.abstract()}},{key:"getTreeSize",value:function(t){return this.fake_use(t),this.abstract()}},{key:"sort",value:function(t){this.fake_use(t),this.abstract()}},{key:"fix",value:function(t,e){this.fake_use(t,e),this.abstract()}},{key:"shift",value:function(t,e){this.fake_use(t,e),this.abstract()}}]),t}(),dv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"horizontal"}},{key:"getPosition",value:function(t){return t.x}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.x=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_x,max:e.max_x}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.x-e.x}))}},{key:"fix",value:function(t,e){t.y=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.y=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].x+=e}}]),i}(lv),cv=function(t){Ad(i,t);var e=hv(i);function i(t){var n;return Nn(this,i),(n=e.call(this)).layout=t,n}return Fn(i,[{key:"curveType",value:function(){return"vertical"}},{key:"getPosition",value:function(t){return t.y}},{key:"setPosition",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:void 0;void 0!==i&&this.layout.hierarchical.addToOrdering(t,i),t.y=e}},{key:"getTreeSize",value:function(t){var e=this.layout.hierarchical.getTreeSize(this.layout.body.nodes,t);return{min:e.min_y,max:e.max_y}}},{key:"sort",value:function(t){av(t,(function(t,e){return t.y-e.y}))}},{key:"fix",value:function(t,e){t.x=this.layout.options.hierarchical.levelSeparation*e,t.options.fixed.x=!0}},{key:"shift",value:function(t,e){this.layout.body.nodes[t].y+=e}}]),i}(lv),uv=Gi.every,fv=Ao("every");gt({target:"Array",proto:!0,forced:!fv},{every:function(t){return uv(this,t,arguments.length>1?arguments[1]:void 0)}});var pv=Ht("Array").every,vv=Array.prototype,gv=function(t){var e=t.every;return t===vv||t instanceof Array&&e===vv.every?pv:e};function yv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return mv(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return mv(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function mv(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}function bv(t,e){var i=new ec;return Wo(t).call(t,(function(t){var e;Wo(e=t.edges).call(e,(function(t){t.connected&&i.add(t)}))})),Wo(i).call(i,(function(t){var i=t.from.id,n=t.to.id;null==e[i]&&(e[i]=0),(null==e[n]||e[i]>=e[n])&&(e[n]=e[i]+1)})),e}function wv(t,e,i,n){var o,r,s=Gr(null),a=Kd(o=wo(Dc(n).call(n))).call(o,(function(t,e){return t+1+e.edges.length}),0),h=i+"Id",l="to"===i?1:-1,d=yv(n);try{var c=function(){var o=uo(r.value,2),d=o[0],c=o[1];if(!n.has(d)||!t(c))return"continue";s[d]=0;for(var u=[c],f=0,p=void 0,v=function(){var t,o;if(!n.has(d))return"continue";var r=s[p.id]+l;if(Wo(t=mr(o=p.edges).call(o,(function(t){return t.connected&&t.to!==t.from&&t[i]!==p&&n.has(t.toId)&&n.has(t.fromId)}))).call(t,(function(t){var n=t[h],o=s[n];(null==o||e(r,o))&&(s[n]=r,u.push(t[i]))})),f>a)return{v:{v:bv(n,s)}};++f};p=u.pop();){var g=v();if("continue"!==g&&"object"===go(g))return g.v}};for(d.s();!(r=d.n()).done;){var u=c();if("continue"!==u&&"object"===go(u))return u.v}}catch(t){d.e(t)}finally{d.f()}return s}var kv=function(){function t(){Nn(this,t),this.childrenReference={},this.parentReference={},this.trees={},this.distributionOrdering={},this.levels={},this.distributionIndex={},this.isTree=!1,this.treeIndex=-1}return Fn(t,[{key:"addRelation",value:function(t,e){void 0===this.childrenReference[t]&&(this.childrenReference[t]=[]),this.childrenReference[t].push(e),void 0===this.parentReference[e]&&(this.parentReference[e]=[]),this.parentReference[e].push(t)}},{key:"checkIfTree",value:function(){for(var t in this.parentReference)if(this.parentReference[t].length>1)return void(this.isTree=!1);this.isTree=!0}},{key:"numTrees",value:function(){return this.treeIndex+1}},{key:"setTreeIndex",value:function(t,e){void 0!==e&&void 0===this.trees[t.id]&&(this.trees[t.id]=e,this.treeIndex=Math.max(e,this.treeIndex))}},{key:"ensureLevel",value:function(t){void 0===this.levels[t]&&(this.levels[t]=0)}},{key:"getMaxLevel",value:function(t){var e=this,i={};return function t(n){if(void 0!==i[n])return i[n];var o=e.levels[n];if(e.childrenReference[n]){var r=e.childrenReference[n];if(r.length>0)for(var s=0;s<r.length;s++)o=Math.max(o,t(r[s]))}return i[n]=o,o}(t)}},{key:"levelDownstream",value:function(t,e){void 0===this.levels[e.id]&&(void 0===this.levels[t.id]&&(this.levels[t.id]=0),this.levels[e.id]=this.levels[t.id]+1)}},{key:"setMinLevelToZero",value:function(t){var e=1e9;for(var i in t)Object.prototype.hasOwnProperty.call(t,i)&&void 0!==this.levels[i]&&(e=Math.min(this.levels[i],e));for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&void 0!==this.levels[n]&&(this.levels[n]-=e)}},{key:"getTreeSize",value:function(t,e){var i=1e9,n=-1e9,o=1e9,r=-1e9;for(var s in this.trees)if(Object.prototype.hasOwnProperty.call(this.trees,s)&&this.trees[s]===e){var a=t[s];i=Math.min(a.x,i),n=Math.max(a.x,n),o=Math.min(a.y,o),r=Math.max(a.y,r)}return{min_x:i,max_x:n,min_y:o,max_y:r}}},{key:"hasSameParent",value:function(t,e){var i=this.parentReference[t.id],n=this.parentReference[e.id];if(void 0===i||void 0===n)return!1;for(var o=0;o<i.length;o++)for(var r=0;r<n.length;r++)if(i[o]==n[r])return!0;return!1}},{key:"inSameSubNetwork",value:function(t,e){return this.trees[t.id]===this.trees[e.id]}},{key:"getLevels",value:function(){return zo(this.distributionOrdering)}},{key:"addToOrdering",value:function(t,e){void 0===this.distributionOrdering[e]&&(this.distributionOrdering[e]=[]);var i=!1,n=this.distributionOrdering[e];for(var o in n)if(n[o]===t){i=!0;break}i||(this.distributionOrdering[e].push(t),this.distributionIndex[t.id]=this.distributionOrdering[e].length-1)}}]),t}(),_v=function(){function t(e){Nn(this,t),this.body=e,this._resetRNG(Math.random()+":"+No()),this.setPhysics=!1,this.options={},this.optionsBackup={physics:{}},this.defaultOptions={randomSeed:void 0,improvedLayout:!0,clusterThreshold:150,hierarchical:{enabled:!1,levelSeparation:150,nodeSpacing:100,treeSpacing:200,blockShifting:!0,edgeMinimization:!0,parentCentralization:!0,direction:"UD",sortMethod:"hubsize"}},At(this.options,this.defaultOptions),this.bindEventListeners()}return Fn(t,[{key:"bindEventListeners",value:function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_dataLoaded",(function(){t.layoutNetwork()})),this.body.emitter.on("_resetHierarchicalLayout",(function(){t.setupHierarchicalLayout()})),this.body.emitter.on("_adjustEdgesForHierarchicalLayout",(function(){if(!0===t.options.hierarchical.enabled){var e=t.direction.curveType();t.body.emitter.emit("_forceDisableDynamicCurves",e,!1)}}))}},{key:"setOptions",value:function(t,e){if(void 0!==t){var i=this.options.hierarchical,n=i.enabled;if(Eh(["randomSeed","improvedLayout","clusterThreshold"],this.options,t),$h(this.options,t,"hierarchical"),void 0!==t.randomSeed&&this._resetRNG(t.randomSeed),!0===i.enabled)return!0===n&&this.body.emitter.emit("refresh",!0),"RL"===i.direction||"DU"===i.direction?i.levelSeparation>0&&(i.levelSeparation*=-1):i.levelSeparation<0&&(i.levelSeparation*=-1),this.setDirectionStrategy(),this.body.emitter.emit("_resetHierarchicalLayout"),this.adaptAllOptionsForHierarchicalLayout(e);if(!0===n)return this.body.emitter.emit("refresh"),Ch(e,this.optionsBackup)}return e}},{key:"_resetRNG",value:function(t){this.initialRandomSeed=t,this._rng=ah(this.initialRandomSeed)}},{key:"adaptAllOptionsForHierarchicalLayout",value:function(t){if(!0===this.options.hierarchical.enabled){var e=this.optionsBackup.physics;void 0===t.physics||!0===t.physics?(t.physics={enabled:void 0===e.enabled||e.enabled,solver:"hierarchicalRepulsion"},e.enabled=void 0===e.enabled||e.enabled,e.solver=e.solver||"barnesHut"):"object"===go(t.physics)?(e.enabled=void 0===t.physics.enabled||t.physics.enabled,e.solver=t.physics.solver||"barnesHut",t.physics.solver="hierarchicalRepulsion"):!1!==t.physics&&(e.solver="barnesHut",t.physics={solver:"hierarchicalRepulsion"});var i=this.direction.curveType();if(void 0===t.edges)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges={smooth:!1};else if(void 0===t.edges.smooth)this.optionsBackup.edges={smooth:{enabled:!0,type:"dynamic"}},t.edges.smooth=!1;else if("boolean"==typeof t.edges.smooth)this.optionsBackup.edges={smooth:t.edges.smooth},t.edges.smooth={enabled:t.edges.smooth,type:i};else{var n=t.edges.smooth;void 0!==n.type&&"dynamic"!==n.type&&(i=n.type),this.optionsBackup.edges={smooth:{enabled:void 0===n.enabled||n.enabled,type:void 0===n.type?"dynamic":n.type,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}},t.edges.smooth={enabled:void 0===n.enabled||n.enabled,type:i,roundness:void 0===n.roundness?.5:n.roundness,forceDirection:void 0!==n.forceDirection&&n.forceDirection}}this.body.emitter.emit("_forceDisableDynamicCurves",i)}return t}},{key:"positionInitially",value:function(t){if(!0!==this.options.hierarchical.enabled){this._resetRNG(this.initialRandomSeed);for(var e=t.length+50,i=0;i<t.length;i++){var n=t[i],o=2*Math.PI*this._rng();void 0===n.x&&(n.x=e*Math.cos(o)),void 0===n.y&&(n.y=e*Math.sin(o))}}}},{key:"layoutNetwork",value:function(){if(!0!==this.options.hierarchical.enabled&&!0===this.options.improvedLayout){for(var t=this.body.nodeIndices,e=0,i=0;i<t.length;i++){!0===this.body.nodes[t[i]].predefinedPosition&&(e+=1)}if(e<.5*t.length){var n=0,o=this.options.clusterThreshold,r={clusterNodeProperties:{shape:"ellipse",label:"",group:"",font:{multi:!1}},clusterEdgeProperties:{label:"",font:{multi:!1},smooth:{enabled:!1}}};if(t.length>o){for(var s=t.length;t.length>o&&n<=10;){n+=1;var a=t.length;if(n%3==0?this.body.modules.clustering.clusterBridges(r):this.body.modules.clustering.clusterOutliers(r),a==t.length&&n%3!=0)return this._declusterAll(),this.body.emitter.emit("_layoutFailed"),void console.info("This network could not be positioned by this version of the improved layout algorithm. Please disable improvedLayout for better performance.")}this.body.modules.kamadaKawai.setOptions({springLength:Math.max(150,2*s)})}n>10&&console.info("The clustering didn't succeed within the amount of interations allowed, progressing with partial result."),this.body.modules.kamadaKawai.solve(t,this.body.edgeIndices,!0),this._shiftToCenter();for(var h=0;h<t.length;h++){var l=this.body.nodes[t[h]];!1===l.predefinedPosition&&(l.x+=70*(.5-this._rng()),l.y+=70*(.5-this._rng()))}this._declusterAll(),this.body.emitter.emit("_repositionBezierNodes")}}}},{key:"_shiftToCenter",value:function(){for(var t=pp.getRangeCore(this.body.nodes,this.body.nodeIndices),e=pp.findCenter(t),i=0;i<this.body.nodeIndices.length;i++){var n=this.body.nodes[this.body.nodeIndices[i]];n.x-=e.x,n.y-=e.y}}},{key:"_declusterAll",value:function(){for(var t=!0;!0===t;){t=!1;for(var e=0;e<this.body.nodeIndices.length;e++)!0===this.body.nodes[this.body.nodeIndices[e]].isCluster&&(t=!0,this.body.modules.clustering.openCluster(this.body.nodeIndices[e],{},!1));!0===t&&this.body.emitter.emit("_dataChanged")}}},{key:"getSeed",value:function(){return this.initialRandomSeed}},{key:"setupHierarchicalLayout",value:function(){if(!0===this.options.hierarchical.enabled&&this.body.nodeIndices.length>0){var t,e,i=!1,n=!1;for(e in this.lastNodeOnLevel={},this.hierarchical=new kv,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,e)&&(void 0!==(t=this.body.nodes[e]).options.level?(i=!0,this.hierarchical.levels[e]=t.options.level):n=!0);if(!0===n&&!0===i)throw new Error("To use the hierarchical layout, nodes require either no predefined levels or levels have to be defined for all nodes.");if(!0===n){var 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k=y-m+c;k<-b+c&&(k=-b+c),k<0&&(t._shiftBlock(n.id,k),e=!0,!0===o&&t._centerParent(n))}}},d=function(n,o){for(var a=o.id,h=o.edges,l=t.hierarchical.levels[o.id],d=t.options.hierarchical.levelSeparation*t.options.hierarchical.levelSeparation,c={},u=[],f=0;f<h.length;f++){var p=h[f];if(p.toId!=p.fromId){var v=p.toId==a?p.from:p.to;c[h[f].id]=v,t.hierarchical.levels[v.id]<l&&u.push(p)}}var g=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n+=r/Math.sqrt(r*r+d)}return n},y=function(e,i){for(var n=0,o=0;o<i.length;o++)if(void 0!==c[i[o].id]){var r=t.direction.getPosition(c[i[o].id])-e;n-=d*Math.pow(r*r+d,-1.5)}return n},m=function(e,i){for(var n=t.direction.getPosition(o),r={},s=0;s<e;s++){var a=g(n,i),h=y(n,i);if(void 0!==r[n-=Math.max(-40,Math.min(40,Math.round(a/h)))])break;r[n]=s}return n},b=m(n,u);!function(n){var a=t.direction.getPosition(o);if(void 0===i[o.id]){var h={};r(o,h),i[o.id]=h}var l=s(i[o.id]),d=l[2],c=l[3],u=n-a,f=0;u>0?f=Math.min(u,c-t.options.hierarchical.nodeSpacing):u<0&&(f=-Math.min(-u,d-t.options.hierarchical.nodeSpacing)),0!=f&&(t._shiftBlock(o.id,f),e=!0)}(b),function(i){var n=t.direction.getPosition(o),r=t._getSpaceAroundNode(o),s=uo(r,2),a=s[0],h=s[1],l=i-n,d=n;l>0?d=Math.min(n+(h-t.options.hierarchical.nodeSpacing),i):l<0&&(d=Math.max(n-(a-t.options.hierarchical.nodeSpacing),i)),d!==n&&(t.direction.setPosition(o,d),e=!0)}(b=m(n,h))};!0===this.options.hierarchical.blockShifting&&(function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i&&(e=!1,h(l,n,!0),!0===e);o++);}(5),function(){for(var e in t.body.nodes)Object.prototype.hasOwnProperty.call(t.body.nodes,e)&&t._centerParent(t.body.nodes[e])}()),!0===this.options.hierarchical.edgeMinimization&&function(i){var n=t.hierarchical.getLevels();n=Xo(n).call(n);for(var o=0;o<i;o++){e=!1;for(var r=0;r<n.length;r++)for(var s=n[r],a=t.hierarchical.distributionOrdering[s],h=0;h<a.length;h++)d(1e3,a[h]);if(!0!==e)break}}(20),!0===this.options.hierarchical.parentCentralization&&function(){var e=t.hierarchical.getLevels();e=Xo(e).call(e);for(var i=0;i<e.length;i++)for(var n=e[i],o=t.hierarchical.distributionOrdering[n],r=0;r<o.length;r++)t._centerParent(o[r])}(),function(){for(var e=o(),i=0,r=0;r<e.length-1;r++){i+=e[r].max-e[r+1].min+t.options.hierarchical.treeSpacing,n(r+1,i)}}()}},{key:"_getSpaceAroundNode",value:function(t,e){var i=!0;void 0===e&&(i=!1);var n=this.hierarchical.levels[t.id];if(void 0!==n){var o=this.hierarchical.distributionIndex[t.id],r=this.direction.getPosition(t),s=this.hierarchical.distributionOrdering[n],a=1e9,h=1e9;if(0!==o){var l=s[o-1];if(!0===i&&void 0===e[l.id]||!1===i)a=r-this.direction.getPosition(l)}if(o!=s.length-1){var d=s[o+1];if(!0===i&&void 0===e[d.id]||!1===i){var c=this.direction.getPosition(d);h=Math.min(h,c-r)}}return[a,h]}return[0,0]}},{key:"_centerParent",value:function(t){if(this.hierarchical.parentReference[t.id])for(var e=this.hierarchical.parentReference[t.id],i=0;i<e.length;i++){var n=e[i],o=this.body.nodes[n],r=this.hierarchical.childrenReference[n];if(void 0!==r){var s=this._getCenterPosition(r),a=this.direction.getPosition(o),h=this._getSpaceAroundNode(o),l=uo(h,2),d=l[0],c=l[1],u=a-s;(u<0&&Math.abs(u)<c-this.options.hierarchical.nodeSpacing||u>0&&Math.abs(u)<d-this.options.hierarchical.nodeSpacing)&&this.direction.setPosition(o,s)}}}},{key:"_placeNodesByHierarchy",value:function(t){for(var e in this.positionedNodes={},t)if(Object.prototype.hasOwnProperty.call(t,e)){var i,n=zo(t[e]);n=this._indexArrayToNodes(n),xc(i=this.direction).call(i,n);for(var o=0,r=0;r<n.length;r++){var s=n[r];if(void 0===this.positionedNodes[s.id]){var a=this.options.hierarchical.nodeSpacing,h=a*o;o>0&&(h=this.direction.getPosition(n[r-1])+a),this.direction.setPosition(s,h,e),this._validatePositionAndContinue(s,e,h),o++}}}}},{key:"_placeBranchNodes",value:function(t,e){var i,n=this.hierarchical.childrenReference[t];if(void 0!==n){for(var o=[],r=0;r<n.length;r++)o.push(this.body.nodes[n[r]]);xc(i=this.direction).call(i,o);for(var s=0;s<o.length;s++){var a=o[s],h=this.hierarchical.levels[a.id];if(!(h>e&&void 0===this.positionedNodes[a.id]))return;var l=this.options.hierarchical.nodeSpacing,d=void 0;d=0===s?this.direction.getPosition(this.body.nodes[t]):this.direction.getPosition(o[s-1])+l,this.direction.setPosition(a,d,h),this._validatePositionAndContinue(a,h,d)}var c=this._getCenterPosition(o);this.direction.setPosition(this.body.nodes[t],c,e)}}},{key:"_validatePositionAndContinue",value:function(t,e,i){if(this.hierarchical.isTree){if(void 0!==this.lastNodeOnLevel[e]){var n=this.direction.getPosition(this.body.nodes[this.lastNodeOnLevel[e]]);if(i-n<this.options.hierarchical.nodeSpacing){var o=n+this.options.hierarchical.nodeSpacing-i,r=this._findCommonParent(this.lastNodeOnLevel[e],t.id);this._shiftBlock(r.withChild,o)}}this.lastNodeOnLevel[e]=t.id,this.positionedNodes[t.id]=!0,this._placeBranchNodes(t.id,e)}}},{key:"_indexArrayToNodes",value:function(t){for(var e=[],i=0;i<t.length;i++)e.push(this.body.nodes[t[i]]);return e}},{key:"_getDistribution",value:function(){var t,e,i={};for(t in this.body.nodes)if(Object.prototype.hasOwnProperty.call(this.body.nodes,t)){e=this.body.nodes[t];var n=void 0===this.hierarchical.levels[t]?0:this.hierarchical.levels[t];this.direction.fix(e,n),void 0===i[n]&&(i[n]={}),i[n][t]=e}return i}},{key:"_getActiveEdges",value:function(t){var e=this,i=[];return Dh(t.edges,(function(t){var n;-1!==Hr(n=e.body.edgeIndices).call(n,t.id)&&i.push(t)})),i}},{key:"_getHubSizes",value:function(){var t=this,e={};Dh(this.body.nodeIndices,(function(i){var n=t.body.nodes[i],o=t._getActiveEdges(n).length;e[o]=!0}));var i=[];return Dh(e,(function(t){i.push(Number(t))})),xc(sv).call(sv,i,(function(t,e){return e-t})),i}},{key:"_determineLevelsByHubsize",value:function(){for(var t=this,e=function(e,i){t.hierarchical.levelDownstream(e,i)},i=this._getHubSizes(),n=function(n){var o=i[n];if(0===o)return"break";Dh(t.body.nodeIndices,(function(i){var n=t.body.nodes[i];o===t._getActiveEdges(n).length&&t._crawlNetwork(e,i)}))},o=0;o<i.length;++o){if("break"===n(o))break}}},{key:"_determineLevelsCustomCallback",value:function(){var t=this;this._crawlNetwork((function(e,i,n){var o=t.hierarchical.levels[e.id];void 0===o&&(o=t.hierarchical.levels[e.id]=1e5);var r=(pp.cloneOptions(e,"node"),pp.cloneOptions(i,"node"),void pp.cloneOptions(n,"edge"));t.hierarchical.levels[i.id]=o+r})),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_determineLevelsDirected",value:function(){var t,e=this,i=Kd(t=this.body.nodeIndices).call(t,(function(t,i){return t.set(i,e.body.nodes[i]),t}),new vd);"roots"===this.options.hierarchical.shakeTowards?this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.from===e}))}),(function(t,e){return e<t}),"to",t)}(i):this.hierarchical.levels=function(t){return wv((function(e){var i,n;return gv(i=mr(n=e.edges).call(n,(function(e){return t.has(e.toId)}))).call(i,(function(t){return t.to===e}))}),(function(t,e){return e>t}),"from",t)}(i),this.hierarchical.setMinLevelToZero(this.body.nodes)}},{key:"_generateMap",value:function(){var t=this;this._crawlNetwork((function(e,i){t.hierarchical.levels[i.id]>t.hierarchical.levels[e.id]&&t.hierarchical.addRelation(e.id,i.id)})),this.hierarchical.checkIfTree()}},{key:"_crawlNetwork",value:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:function(){},i=arguments.length>1?arguments[1]:void 0,n={},o=function i(o,r){if(void 0===n[o.id]){var s;t.hierarchical.setTreeIndex(o,r),n[o.id]=!0;for(var a=t._getActiveEdges(o),h=0;h<a.length;h++){var l=a[h];!0===l.connected&&(s=l.toId==o.id?l.from:l.to,o.id!=s.id&&(e(o,s,l),i(s,r)))}}};if(void 0===i)for(var r=0,s=0;s<this.body.nodeIndices.length;s++){var a=this.body.nodeIndices[s];if(void 0===n[a]){var h=this.body.nodes[a];o(h,r),r+=1}}else{var l=this.body.nodes[i];if(void 0===l)return void console.error("Node not found:",i);o(l)}}},{key:"_shiftBlock",value:function(t,e){var i=this,n={};!function t(o){if(!n[o]){n[o]=!0,i.direction.shift(o,e);var r=i.hierarchical.childrenReference[o];if(void 0!==r)for(var s=0;s<r.length;s++)t(r[s])}}(t)}},{key:"_findCommonParent",value:function(t,e){var i=this,n={};return function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];e[s]=!0,t(e,s)}}(n,t),function t(e,n){var o=i.hierarchical.parentReference[n];if(void 0!==o)for(var r=0;r<o.length;r++){var s=o[r];if(void 0!==e[s])return{foundParent:s,withChild:n};var a=t(e,s);if(null!==a.foundParent)return a}return{foundParent:null,withChild:n}}(n,e)}},{key:"setDirectionStrategy",value:function(){var t="UD"===this.options.hierarchical.direction||"DU"===this.options.hierarchical.direction;this.direction=t?new dv(this):new cv(this)}},{key:"_getCenterPosition",value:function(t){for(var e=1e9,i=-1e9,n=0;n<t.length;n++){var o=void 0;if(void 0!==t[n].id)o=t[n];else{var r=t[n];o=this.body.nodes[r]}var s=this.direction.getPosition(o);e=Math.min(e,s),i=Math.max(i,s)}return.5*(e+i)}}]),t}();function xv(t,e){var i=void 0!==ko&&Bi(t)||t["@@iterator"];if(!i){if(So(t)||(i=function(t,e){var i;if(!t)return;if("string"==typeof t)return Ev(t,e);var n=Oo(i=Object.prototype.toString.call(t)).call(i,8,-1);"Object"===n&&t.constructor&&(n=t.constructor.name);if("Map"===n||"Set"===n)return Ei(t);if("Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n))return Ev(t,e)}(t))||e&&t&&"number"==typeof t.length){i&&(t=i);var n=0,o=function(){};return{s:o,n:function(){return n>=t.length?{done:!0}:{done:!1,value:t[n++]}},e:function(t){throw t},f:o}}throw new TypeError("Invalid attempt to iterate non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}var r,s=!0,a=!1;return{s:function(){i=i.call(t)},n:function(){var t=i.next();return s=t.done,t},e:function(t){a=!0,r=t},f:function(){try{s||null==i.return||i.return()}finally{if(a)throw r}}}}function Ev(t,e){(null==e||e>t.length)&&(e=t.length);for(var i=0,n=new Array(e);i<e;i++)n[i]=t[i];return n}var Ov=function(){function t(e,i,n,o){var r,s,a=this;Nn(this,t),this.body=e,this.canvas=i,this.selectionHandler=n,this.interactionHandler=o,this.editMode=!1,this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0,this._domEventListenerCleanupQueue=[],this.temporaryUIFunctions={},this.temporaryEventFunctions=[],this.touchTime=0,this.temporaryIds={nodes:[],edges:[]},this.guiEnabled=!1,this.inMode=!1,this.selectedControlNode=void 0,this.options={},this.defaultOptions={enabled:!1,initiallyActive:!1,addNode:!0,addEdge:!0,editNode:void 0,editEdge:!0,deleteNode:!0,deleteEdge:!0,controlNodeStyle:{shape:"dot",size:6,color:{background:"#ff0000",border:"#3c3c3c",highlight:{background:"#07f968",border:"#3c3c3c"}},borderWidth:2,borderWidthSelected:2}},At(this.options,this.defaultOptions),this.body.emitter.on("destroy",(function(){a._clean()})),this.body.emitter.on("_dataChanged",Vt(r=this._restore).call(r,this)),this.body.emitter.on("_resetData",Vt(s=this._restore).call(s,this))}return Fn(t,[{key:"_restore",value:function(){!1!==this.inMode&&(!0===this.options.initiallyActive?this.enableEditMode():this.disableEditMode())}},{key:"setOptions",value:function(t,e,i){void 0!==e&&(void 0!==e.locale?this.options.locale=e.locale:this.options.locale=i.locale,void 0!==e.locales?this.options.locales=e.locales:this.options.locales=i.locales),void 0!==t&&("boolean"==typeof t?this.options.enabled=t:(this.options.enabled=!0,Ch(this.options,t)),!0===this.options.initiallyActive&&(this.editMode=!0),this._setup())}},{key:"toggleEditMode",value:function(){!0===this.editMode?this.disableEditMode():this.enableEditMode()}},{key:"enableEditMode",value:function(){this.editMode=!0,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="block",this.closeDiv.style.display="block",this.editModeDiv.style.display="none",this.showManipulatorToolbar())}},{key:"disableEditMode",value:function(){this.editMode=!1,this._clean(),!0===this.guiEnabled&&(this.manipulationDiv.style.display="none",this.closeDiv.style.display="none",this.editModeDiv.style.display="block",this._createEditButton())}},{key:"showManipulatorToolbar",value:function(){if(this._clean(),this.manipulationDOM={},!0===this.guiEnabled){var t,e;this.editMode=!0,this.manipulationDiv.style.display="block",this.closeDiv.style.display="block";var i=this.selectionHandler.getSelectedNodeCount(),n=this.selectionHandler.getSelectedEdgeCount(),o=i+n,r=this.options.locales[this.options.locale],s=!1;!1!==this.options.addNode&&(this._createAddNodeButton(r),s=!0),!1!==this.options.addEdge&&(!0===s?this._createSeperator(1):s=!0,this._createAddEdgeButton(r)),1===i&&"function"==typeof this.options.editNode?(!0===s?this._createSeperator(2):s=!0,this._createEditNodeButton(r)):1===n&&0===i&&!1!==this.options.editEdge&&(!0===s?this._createSeperator(3):s=!0,this._createEditEdgeButton(r)),0!==o&&(i>0&&!1!==this.options.deleteNode||0===i&&!1!==this.options.deleteEdge)&&(!0===s&&this._createSeperator(4),this._createDeleteButton(r)),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this)),this._temporaryBindEvent("select",Vt(e=this.showManipulatorToolbar).call(e,this))}this.body.emitter.emit("_redraw")}},{key:"addNodeMode",value:function(){var t;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addNode",!0===this.guiEnabled){var e,i=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(i),this._createSeperator(),this._createDescription(i.addDescription||this.options.locales.en.addDescription),this._bindElementEvents(this.closeDiv,Vt(e=this.toggleEditMode).call(e,this))}this._temporaryBindEvent("click",Vt(t=this._performAddNode).call(t,this))}},{key:"editNode",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean();var e=this.selectionHandler.getSelectedNodes()[0];if(void 0!==e){if(this.inMode="editNode","function"!=typeof this.options.editNode)throw new Error("No function has been configured to handle the editing of nodes.");if(!0!==e.isCluster){var i=Ch({},e.options,!1);if(i.x=e.x,i.y=e.y,2!==this.options.editNode.length)throw new Error("The function for edit does not support two arguments (data, callback)");this.options.editNode(i,(function(e){null!=e&&"editNode"===t.inMode&&t.body.data.nodes.getDataSet().update(e),t.showManipulatorToolbar()}))}else alert(this.options.locales[this.options.locale].editClusterError||this.options.locales.en.editClusterError)}else this.showManipulatorToolbar()}},{key:"addEdgeMode",value:function(){var t,e,i,n,o;if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="addEdge",!0===this.guiEnabled){var r,s=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(s),this._createSeperator(),this._createDescription(s.edgeDescription||this.options.locales.en.edgeDescription),this._bindElementEvents(this.closeDiv,Vt(r=this.toggleEditMode).call(r,this))}this._temporaryBindUI("onTouch",Vt(t=this._handleConnect).call(t,this)),this._temporaryBindUI("onDragEnd",Vt(e=this._finishConnect).call(e,this)),this._temporaryBindUI("onDrag",Vt(i=this._dragControlNode).call(i,this)),this._temporaryBindUI("onRelease",Vt(n=this._finishConnect).call(n,this)),this._temporaryBindUI("onDragStart",Vt(o=this._dragStartEdge).call(o,this)),this._temporaryBindUI("onHold",(function(){}))}},{key:"editEdgeMode",value:function(){if(!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="editEdge","object"!==go(this.options.editEdge)||"function"!=typeof this.options.editEdge.editWithoutDrag||(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0===this.edgeBeingEditedId)){if(!0===this.guiEnabled){var t,e=this.options.locales[this.options.locale];this.manipulationDOM={},this._createBackButton(e),this._createSeperator(),this._createDescription(e.editEdgeDescription||this.options.locales.en.editEdgeDescription),this._bindElementEvents(this.closeDiv,Vt(t=this.toggleEditMode).call(t,this))}if(this.edgeBeingEditedId=this.selectionHandler.getSelectedEdgeIds()[0],void 0!==this.edgeBeingEditedId){var i,n,o,r,s=this.body.edges[this.edgeBeingEditedId],a=this._getNewTargetNode(s.from.x,s.from.y),h=this._getNewTargetNode(s.to.x,s.to.y);this.temporaryIds.nodes.push(a.id),this.temporaryIds.nodes.push(h.id),this.body.nodes[a.id]=a,this.body.nodeIndices.push(a.id),this.body.nodes[h.id]=h,this.body.nodeIndices.push(h.id),this._temporaryBindUI("onTouch",Vt(i=this._controlNodeTouch).call(i,this)),this._temporaryBindUI("onTap",(function(){})),this._temporaryBindUI("onHold",(function(){})),this._temporaryBindUI("onDragStart",Vt(n=this._controlNodeDragStart).call(n,this)),this._temporaryBindUI("onDrag",Vt(o=this._controlNodeDrag).call(o,this)),this._temporaryBindUI("onDragEnd",Vt(r=this._controlNodeDragEnd).call(r,this)),this._temporaryBindUI("onMouseMove",(function(){})),this._temporaryBindEvent("beforeDrawing",(function(t){var e=s.edgeType.findBorderPositions(t);!1===a.selected&&(a.x=e.from.x,a.y=e.from.y),!1===h.selected&&(h.x=e.to.x,h.y=e.to.y)})),this.body.emitter.emit("_redraw")}else this.showManipulatorToolbar()}else{var l=this.body.edges[this.edgeBeingEditedId];this._performEditEdge(l.from.id,l.to.id)}}},{key:"deleteSelected",value:function(){var t=this;!0!==this.editMode&&this.enableEditMode(),this._clean(),this.inMode="delete";var e=this.selectionHandler.getSelectedNodeIds(),i=this.selectionHandler.getSelectedEdgeIds(),n=void 0;if(e.length>0){for(var o=0;o<e.length;o++)if(!0===this.body.nodes[e[o]].isCluster)return void alert(this.options.locales[this.options.locale].deleteClusterError||this.options.locales.en.deleteClusterError);"function"==typeof this.options.deleteNode&&(n=this.options.deleteNode)}else i.length>0&&"function"==typeof this.options.deleteEdge&&(n=this.options.deleteEdge);if("function"==typeof n){var r={nodes:e,edges:i};if(2!==n.length)throw new Error("The function for delete does not support two arguments (data, callback)");n(r,(function(e){null!=e&&"delete"===t.inMode?(t.body.data.edges.getDataSet().remove(e.edges),t.body.data.nodes.getDataSet().remove(e.nodes),t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar()):(t.body.emitter.emit("startSimulation"),t.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().remove(i),this.body.data.nodes.getDataSet().remove(e),this.body.emitter.emit("startSimulation"),this.showManipulatorToolbar()}},{key:"_setup",value:function(){!0===this.options.enabled?(this.guiEnabled=!0,this._createWrappers(),!1===this.editMode?this._createEditButton():this.showManipulatorToolbar()):(this._removeManipulationDOM(),this.guiEnabled=!1)}},{key:"_createWrappers",value:function(){var t,e;(void 0===this.manipulationDiv&&(this.manipulationDiv=document.createElement("div"),this.manipulationDiv.className="vis-manipulation",!0===this.editMode?this.manipulationDiv.style.display="block":this.manipulationDiv.style.display="none",this.canvas.frame.appendChild(this.manipulationDiv)),void 0===this.editModeDiv&&(this.editModeDiv=document.createElement("div"),this.editModeDiv.className="vis-edit-mode",!0===this.editMode?this.editModeDiv.style.display="none":this.editModeDiv.style.display="block",this.canvas.frame.appendChild(this.editModeDiv)),void 0===this.closeDiv)&&(this.closeDiv=document.createElement("button"),this.closeDiv.className="vis-close",this.closeDiv.setAttribute("aria-label",null!==(t=null===(e=this.options.locales[this.options.locale])||void 0===e?void 0:e.close)&&void 0!==t?t:this.options.locales.en.close),this.closeDiv.style.display=this.manipulationDiv.style.display,this.canvas.frame.appendChild(this.closeDiv))}},{key:"_getNewTargetNode",value:function(t,e){var i=Ch({},this.options.controlNodeStyle);i.id="targetNode"+Wc(),i.hidden=!1,i.physics=!1,i.x=t,i.y=e;var n=this.body.functions.createNode(i);return n.shape.boundingBox={left:t,right:t,top:e,bottom:e},n}},{key:"_createEditButton",value:function(){var t;this._clean(),this.manipulationDOM={},mh(this.editModeDiv);var e=this.options.locales[this.options.locale],i=this._createButton("editMode","vis-edit vis-edit-mode",e.edit||this.options.locales.en.edit);this.editModeDiv.appendChild(i),this._bindElementEvents(i,Vt(t=this.toggleEditMode).call(t,this))}},{key:"_clean",value:function(){this.inMode=!1,!0===this.guiEnabled&&(mh(this.editModeDiv),mh(this.manipulationDiv),this._cleanupDOMEventListeners()),this._cleanupTemporaryNodesAndEdges(),this._unbindTemporaryUIs(),this._unbindTemporaryEvents(),this.body.emitter.emit("restorePhysics")}},{key:"_cleanupDOMEventListeners",value:function(){var t,e,i=xv(er(t=this._domEventListenerCleanupQueue).call(t,0));try{for(i.s();!(e=i.n()).done;){(0,e.value)()}}catch(t){i.e(t)}finally{i.f()}}},{key:"_removeManipulationDOM",value:function(){this._clean(),mh(this.manipulationDiv),mh(this.editModeDiv),mh(this.closeDiv),this.manipulationDiv&&this.canvas.frame.removeChild(this.manipulationDiv),this.editModeDiv&&this.canvas.frame.removeChild(this.editModeDiv),this.closeDiv&&this.canvas.frame.removeChild(this.closeDiv),this.manipulationDiv=void 0,this.editModeDiv=void 0,this.closeDiv=void 0}},{key:"_createSeperator",value:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:1;this.manipulationDOM["seperatorLineDiv"+t]=document.createElement("div"),this.manipulationDOM["seperatorLineDiv"+t].className="vis-separator-line",this.manipulationDiv.appendChild(this.manipulationDOM["seperatorLineDiv"+t])}},{key:"_createAddNodeButton",value:function(t){var e,i=this._createButton("addNode","vis-add",t.addNode||this.options.locales.en.addNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addNodeMode).call(e,this))}},{key:"_createAddEdgeButton",value:function(t){var e,i=this._createButton("addEdge","vis-connect",t.addEdge||this.options.locales.en.addEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.addEdgeMode).call(e,this))}},{key:"_createEditNodeButton",value:function(t){var e,i=this._createButton("editNode","vis-edit",t.editNode||this.options.locales.en.editNode);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editNode).call(e,this))}},{key:"_createEditEdgeButton",value:function(t){var e,i=this._createButton("editEdge","vis-edit",t.editEdge||this.options.locales.en.editEdge);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.editEdgeMode).call(e,this))}},{key:"_createDeleteButton",value:function(t){var e,i;i=this.options.rtl?"vis-delete-rtl":"vis-delete";var n=this._createButton("delete",i,t.del||this.options.locales.en.del);this.manipulationDiv.appendChild(n),this._bindElementEvents(n,Vt(e=this.deleteSelected).call(e,this))}},{key:"_createBackButton",value:function(t){var e,i=this._createButton("back","vis-back",t.back||this.options.locales.en.back);this.manipulationDiv.appendChild(i),this._bindElementEvents(i,Vt(e=this.showManipulatorToolbar).call(e,this))}},{key:"_createButton",value:function(t,e,i){var n=arguments.length>3&&void 0!==arguments[3]?arguments[3]:"vis-label";return this.manipulationDOM[t+"Div"]=document.createElement("button"),this.manipulationDOM[t+"Div"].className="vis-button "+e,this.manipulationDOM[t+"Label"]=document.createElement("div"),this.manipulationDOM[t+"Label"].className=n,this.manipulationDOM[t+"Label"].innerText=i,this.manipulationDOM[t+"Div"].appendChild(this.manipulationDOM[t+"Label"]),this.manipulationDOM[t+"Div"]}},{key:"_createDescription",value:function(t){this.manipulationDOM.descriptionLabel=document.createElement("div"),this.manipulationDOM.descriptionLabel.className="vis-none",this.manipulationDOM.descriptionLabel.innerText=t,this.manipulationDiv.appendChild(this.manipulationDOM.descriptionLabel)}},{key:"_temporaryBindEvent",value:function(t,e){this.temporaryEventFunctions.push({event:t,boundFunction:e}),this.body.emitter.on(t,e)}},{key:"_temporaryBindUI",value:function(t,e){if(void 0===this.body.eventListeners[t])throw new Error("This UI function does not exist. Typo? You tried: "+t+" possible are: "+es(zo(this.body.eventListeners)));this.temporaryUIFunctions[t]=this.body.eventListeners[t],this.body.eventListeners[t]=e}},{key:"_unbindTemporaryUIs",value:function(){for(var t in this.temporaryUIFunctions)Object.prototype.hasOwnProperty.call(this.temporaryUIFunctions,t)&&(this.body.eventListeners[t]=this.temporaryUIFunctions[t],delete this.temporaryUIFunctions[t]);this.temporaryUIFunctions={}}},{key:"_unbindTemporaryEvents",value:function(){for(var t=0;t<this.temporaryEventFunctions.length;t++){var e=this.temporaryEventFunctions[t].event,i=this.temporaryEventFunctions[t].boundFunction;this.body.emitter.off(e,i)}this.temporaryEventFunctions=[]}},{key:"_bindElementEvents",value:function(t,e){var i=new ll(t,{});_p(i,e),this._domEventListenerCleanupQueue.push((function(){i.destroy()}));var n=function(t){var i=t.keyCode,n=t.key;"Enter"!==n&&" "!==n&&13!==i&&32!==i||e()};t.addEventListener("keyup",n,!1),this._domEventListenerCleanupQueue.push((function(){t.removeEventListener("keyup",n,!1)}))}},{key:"_cleanupTemporaryNodesAndEdges",value:function(){for(var t=0;t<this.temporaryIds.edges.length;t++){var e;this.body.edges[this.temporaryIds.edges[t]].disconnect(),delete this.body.edges[this.temporaryIds.edges[t]];var i,n=Hr(e=this.body.edgeIndices).call(e,this.temporaryIds.edges[t]);if(-1!==n)er(i=this.body.edgeIndices).call(i,n,1)}for(var o=0;o<this.temporaryIds.nodes.length;o++){var r;delete this.body.nodes[this.temporaryIds.nodes[o]];var s,a=Hr(r=this.body.nodeIndices).call(r,this.temporaryIds.nodes[o]);if(-1!==a)er(s=this.body.nodeIndices).call(s,a,1)}this.temporaryIds={nodes:[],edges:[]}}},{key:"_controlNodeTouch",value:function(t){this.selectionHandler.unselectAll(),this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation)}},{key:"_controlNodeDragStart",value:function(){var t=this.lastTouch,e=this.selectionHandler._pointerToPositionObject(t),i=this.body.nodes[this.temporaryIds.nodes[0]],n=this.body.nodes[this.temporaryIds.nodes[1]],o=this.body.edges[this.edgeBeingEditedId];this.selectedControlNode=void 0;var r=i.isOverlappingWith(e),s=n.isOverlappingWith(e);!0===r?(this.selectedControlNode=i,o.edgeType.from=i):!0===s&&(this.selectedControlNode=n,o.edgeType.to=n),void 0!==this.selectedControlNode&&this.selectionHandler.selectObject(this.selectedControlNode),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDrag",value:function(t){this.body.emitter.emit("disablePhysics");var e=this.body.functions.getPointer(t.center),i=this.canvas.DOMtoCanvas(e);void 0!==this.selectedControlNode?(this.selectedControlNode.x=i.x,this.selectedControlNode.y=i.y):this.interactionHandler.onDrag(t),this.body.emitter.emit("_redraw")}},{key:"_controlNodeDragEnd",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=this.body.edges[this.edgeBeingEditedId];if(void 0!==this.selectedControlNode){this.selectionHandler.unselectAll();for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--)if(o[s]!==this.selectedControlNode.id){r=this.body.nodes[o[s]];break}if(void 0!==r&&void 0!==this.selectedControlNode)if(!0===r.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var a=this.body.nodes[this.temporaryIds.nodes[0]];this.selectedControlNode.id===a.id?this._performEditEdge(r.id,n.to.id):this._performEditEdge(n.from.id,r.id)}else n.updateEdgeType(),this.body.emitter.emit("restorePhysics");this.body.emitter.emit("_redraw")}}},{key:"_handleConnect",value:function(t){if((new Date).valueOf()-this.touchTime>100){this.lastTouch=this.body.functions.getPointer(t.center),this.lastTouch.translation=At({},this.body.view.translation),this.interactionHandler.drag.pointer=this.lastTouch,this.interactionHandler.drag.translation=this.lastTouch.translation;var e=this.lastTouch,i=this.selectionHandler.getNodeAt(e);if(void 0!==i)if(!0===i.isCluster)alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError);else{var n=this._getNewTargetNode(i.x,i.y);this.body.nodes[n.id]=n,this.body.nodeIndices.push(n.id);var o=this.body.functions.createEdge({id:"connectionEdge"+Wc(),from:i.id,to:n.id,physics:!1,smooth:{enabled:!0,type:"continuous",roundness:.5}});this.body.edges[o.id]=o,this.body.edgeIndices.push(o.id),this.temporaryIds.nodes.push(n.id),this.temporaryIds.edges.push(o.id)}this.touchTime=(new Date).valueOf()}}},{key:"_dragControlNode",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}if(t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragging",t,e),void 0!==this.temporaryIds.nodes[0]){var h=this.body.nodes[this.temporaryIds.nodes[0]];h.x=this.canvas._XconvertDOMtoCanvas(e.x),h.y=this.canvas._YconvertDOMtoCanvas(e.y),this.body.emitter.emit("_redraw")}else this.interactionHandler.onDrag(t)}},{key:"_finishConnect",value:function(t){var e=this.body.functions.getPointer(t.center),i=this.selectionHandler._pointerToPositionObject(e),n=void 0;void 0!==this.temporaryIds.edges[0]&&(n=this.body.edges[this.temporaryIds.edges[0]].fromId);for(var o=this.selectionHandler._getAllNodesOverlappingWith(i),r=void 0,s=o.length-1;s>=0;s--){var a;if(-1===Hr(a=this.temporaryIds.nodes).call(a,o[s])){r=this.body.nodes[o[s]];break}}this._cleanupTemporaryNodesAndEdges(),void 0!==r&&(!0===r.isCluster?alert(this.options.locales[this.options.locale].createEdgeError||this.options.locales.en.createEdgeError):void 0!==this.body.nodes[n]&&void 0!==this.body.nodes[r.id]&&this._performAddEdge(n,r.id)),t.controlEdge={from:n,to:r?r.id:void 0},this.selectionHandler.generateClickEvent("controlNodeDragEnd",t,e),this.body.emitter.emit("_redraw")}},{key:"_dragStartEdge",value:function(t){var e=this.lastTouch;this.selectionHandler.generateClickEvent("dragStart",t,e,void 0,!0)}},{key:"_performAddNode",value:function(t){var e=this,i={id:Wc(),x:t.pointer.canvas.x,y:t.pointer.canvas.y,label:"new"};if("function"==typeof this.options.addNode){if(2!==this.options.addNode.length)throw this.showManipulatorToolbar(),new Error("The function for add does not support two arguments (data,callback)");this.options.addNode(i,(function(t){null!=t&&"addNode"===e.inMode&&e.body.data.nodes.getDataSet().add(t),e.showManipulatorToolbar()}))}else this.body.data.nodes.getDataSet().add(i),this.showManipulatorToolbar()}},{key:"_performAddEdge",value:function(t,e){var i=this,n={from:t,to:e};if("function"==typeof this.options.addEdge){if(2!==this.options.addEdge.length)throw new Error("The function for connect does not support two arguments (data,callback)");this.options.addEdge(n,(function(t){null!=t&&"addEdge"===i.inMode&&(i.body.data.edges.getDataSet().add(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else this.body.data.edges.getDataSet().add(n),this.selectionHandler.unselectAll(),this.showManipulatorToolbar()}},{key:"_performEditEdge",value:function(t,e){var i=this,n={id:this.edgeBeingEditedId,from:t,to:e,label:this.body.data.edges.get(this.edgeBeingEditedId).label},o=this.options.editEdge;if("object"===go(o)&&(o=o.editWithoutDrag),"function"==typeof o){if(2!==o.length)throw new Error("The function for edit does not support two arguments (data, callback)");o(n,(function(t){null==t||"editEdge"!==i.inMode?(i.body.edges[n.id].updateEdgeType(),i.body.emitter.emit("_redraw"),i.showManipulatorToolbar()):(i.body.data.edges.getDataSet().update(t),i.selectionHandler.unselectAll(),i.showManipulatorToolbar())}))}else 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n;return!(!dr(t).call(t,"physics")||!dr(n=zv.physics.solver).call(n,e)||i.physics.solver===e||"wind"===e)},Av=Object.freeze({__proto__:null,configuratorHideOption:Nv,allOptions:Bv,configureOptions:zv}),Fv=function(){function t(){Nn(this,t)}return Fn(t,[{key:"getDistances",value:function(t,e,i){for(var n={},o=t.edges,r=0;r<e.length;r++){var s={};n[e[r]]=s;for(var a=0;a<e.length;a++)s[e[a]]=r==a?0:1e9}for(var h=0;h<i.length;h++){var l=o[i[h]];!0===l.connected&&void 0!==n[l.fromId]&&void 0!==n[l.toId]&&(n[l.fromId][l.toId]=1,n[l.toId][l.fromId]=1)}for(var d=e.length,c=0;c<d;c++)for(var u=e[c],f=n[u],p=0;p<d-1;p++)for(var v=e[p],g=n[v],y=p+1;y<d;y++){var m=e[y],b=n[m],w=Math.min(g[m],g[u]+f[m]);g[m]=w,b[v]=w}return n}}]),t}(),jv=function(){function t(e,i,n){Nn(this,t),this.body=e,this.springLength=i,this.springConstant=n,this.distanceSolver=new Fv}return Fn(t,[{key:"setOptions",value:function(t){t&&(t.springLength&&(this.springLength=t.springLength),t.springConstant&&(this.springConstant=t.springConstant))}},{key:"solve",value:function(t,e){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=this.distanceSolver.getDistances(this.body,t,e);this._createL_matrix(n),this._createK_matrix(n),this._createE_matrix();for(var o=.01,r=1,s=0,a=Math.max(1e3,Math.min(10*this.body.nodeIndices.length,6e3)),h=5,l=1e9,d=0,c=0,u=0,f=0,p=0;l>o&&s<a;){s+=1;var v=this._getHighestEnergyNode(i),g=uo(v,4);for(d=g[0],l=g[1],c=g[2],u=g[3],f=l,p=0;f>r&&p<h;){p+=1,this._moveNode(d,c,u);var y=this._getEnergy(d),m=uo(y,3);f=m[0],c=m[1],u=m[2]}}}},{key:"_getHighestEnergyNode",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=0,o=e[0],r=0,s=0,a=0;a<e.length;a++){var h=e[a];if(!0!==i[h].predefinedPosition||!0===i[h].isCluster&&!0===t||!0!==i[h].options.fixed.x||!0!==i[h].options.fixed.y){var l=this._getEnergy(h),d=uo(l,3),c=d[0],u=d[1],f=d[2];n<c&&(n=c,o=h,r=u,s=f)}}return[o,n,r,s]}},{key:"_getEnergy",value:function(t){var e=uo(this.E_sums[t],2),i=e[0],n=e[1];return[Math.sqrt(Math.pow(i,2)+Math.pow(n,2)),i,n]}},{key:"_moveNode",value:function(t,e,i){for(var n=this.body.nodeIndices,o=this.body.nodes,r=0,s=0,a=0,h=o[t].x,l=o[t].y,d=this.K_matrix[t],c=this.L_matrix[t],u=0;u<n.length;u++){var f=n[u];if(f!==t){var p=o[f].x,v=o[f].y,g=d[f],y=c[f],m=1/Math.pow(Math.pow(h-p,2)+Math.pow(l-v,2),1.5);r+=g*(1-y*Math.pow(l-v,2)*m),s+=g*(y*(h-p)*(l-v)*m),a+=g*(1-y*Math.pow(h-p,2)*m)}}var b=(e/r+i/s)/(s/r-a/s),w=-(s*b+e)/r;o[t].x+=w,o[t].y+=b,this._updateE_matrix(t)}},{key:"_createL_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springLength;this.L_matrix=[];for(var n=0;n<e.length;n++){this.L_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.L_matrix[e[n]][e[o]]=i*t[e[n]][e[o]]}}},{key:"_createK_matrix",value:function(t){var e=this.body.nodeIndices,i=this.springConstant;this.K_matrix=[];for(var n=0;n<e.length;n++){this.K_matrix[e[n]]={};for(var o=0;o<e.length;o++)this.K_matrix[e[n]][e[o]]=i*Math.pow(t[e[n]][e[o]],-2)}}},{key:"_createE_matrix",value:function(){var t=this.body.nodeIndices,e=this.body.nodes;this.E_matrix={},this.E_sums={};for(var i=0;i<t.length;i++)this.E_matrix[t[i]]=[];for(var n=0;n<t.length;n++){for(var o=t[n],r=e[o].x,s=e[o].y,a=0,h=0,l=n;l<t.length;l++){var d=t[l];if(d!==o){var c=e[d].x,u=e[d].y,f=1/Math.sqrt(Math.pow(r-c,2)+Math.pow(s-u,2));this.E_matrix[o][l]=[this.K_matrix[o][d]*(r-c-this.L_matrix[o][d]*(r-c)*f),this.K_matrix[o][d]*(s-u-this.L_matrix[o][d]*(s-u)*f)],this.E_matrix[d][n]=this.E_matrix[o][l],a+=this.E_matrix[o][l][0],h+=this.E_matrix[o][l][1]}}this.E_sums[o]=[a,h]}}},{key:"_updateE_matrix",value:function(t){for(var e=this.body.nodeIndices,i=this.body.nodes,n=this.E_matrix[t],o=this.K_matrix[t],r=this.L_matrix[t],s=i[t].x,a=i[t].y,h=0,l=0,d=0;d<e.length;d++){var c=e[d];if(c!==t){var u=n[d],f=u[0],p=u[1],v=i[c].x,g=i[c].y,y=1/Math.sqrt(Math.pow(s-v,2)+Math.pow(a-g,2)),m=o[c]*(s-v-r[c]*(s-v)*y),b=o[c]*(a-g-r[c]*(a-g)*y);n[d]=[m,b],h+=m,l+=b;var w=this.E_sums[c];w[0]+=m-f,w[1]+=b-p}}this.E_sums[t]=[h,l]}}]),t}();function Rv(t,e,i){var n,o,r,s,a=this;if(!(this instanceof Rv))throw new SyntaxError("Constructor must be called with the new operator");this.options={},this.defaultOptions={locale:"en",locales:Kl,clickToUse:!1},At(this.options,this.defaultOptions),this.body={container:t,nodes:{},nodeIndices:[],edges:{},edgeIndices:[],emitter:{on:Vt(n=this.on).call(n,this),off:Vt(o=this.off).call(o,this),emit:Vt(r=this.emit).call(r,this),once:Vt(s=this.once).call(s,this)},eventListeners:{onTap:function(){},onTouch:function(){},onDoubleTap:function(){},onHold:function(){},onDragStart:function(){},onDrag:function(){},onDragEnd:function(){},onMouseWheel:function(){},onPinch:function(){},onMouseMove:function(){},onRelease:function(){},onContext:function(){}},data:{nodes:null,edges:null},functions:{createNode:function(){},createEdge:function(){},getPointer:function(){}},modules:{},view:{scale:1,translation:{x:0,y:0}},selectionBox:{show:!1,position:{start:{x:0,y:0},end:{x:0,y:0}}}},this.bindEventListeners(),this.images=new Zl((function(){return a.body.emitter.emit("_requestRedraw")})),this.groups=new gd,this.canvas=new Ep(this.body),this.selectionHandler=new ov(this.body,this.canvas),this.interactionHandler=new Ip(this.body,this.canvas,this.selectionHandler),this.view=new Cp(this.body,this.canvas),this.renderer=new wp(this.body,this.canvas),this.physics=new fp(this.body),this.layoutEngine=new _v(this.body),this.clustering=new yp(this.body),this.manipulation=new Ov(this.body,this.canvas,this.selectionHandler,this.interactionHandler),this.nodesHandler=new pf(this.body,this.images,this.groups,this.layoutEngine),this.edgesHandler=new ip(this.body,this.images,this.groups),this.body.modules.kamadaKawai=new jv(this.body,150,.05),this.body.modules.clustering=this.clustering,this.canvas._create(),this.setOptions(i),this.setData(e)}function Lv(t){for(var e in t)Object.prototype.hasOwnProperty.call(t,e)&&(t[e].redundant=t[e].used,t[e].used=[])}function Hv(t){for(var e in t)if(Object.prototype.hasOwnProperty.call(t,e)&&t[e].redundant){for(var i=0;i<t[e].redundant.length;i++)t[e].redundant[i].parentNode.removeChild(t[e].redundant[i]);t[e].redundant=[]}}function Wv(t,e,i){var n;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(n=e[t].redundant[0],e[t].redundant.shift()):(n=document.createElementNS("http://www.w3.org/2000/svg",t),i.appendChild(n)):(n=document.createElementNS("http://www.w3.org/2000/svg",t),e[t]={used:[],redundant:[]},i.appendChild(n)),e[t].used.push(n),n}Zt(Rv.prototype),Rv.prototype.setOptions=function(t){var e=this;if(null===t&&(t=void 0),void 0!==t){!0===ul.validate(t,Bv)&&console.error("%cErrors have been found in the supplied options object.",cl);if(Eh(["locale","locales","clickToUse"],this.options,t),void 0!==t.locale&&(t.locale=function(t,e){try{var i=e.split(/[-_ /]/,2),n=uo(i,2),o=n[0],r=n[1],s=null!=o?o.toLowerCase():null,a=null!=r?r.toUpperCase():null;if(s&&a){var h,l=s+"-"+a;if(Object.prototype.hasOwnProperty.call(t,l))return l;console.warn(Eo(h="Unknown variant ".concat(a," of language ")).call(h,s,"."))}if(s){var d=s;if(Object.prototype.hasOwnProperty.call(t,d))return d;console.warn("Unknown language ".concat(s))}return console.warn("Unknown locale ".concat(e,", falling back to English.")),"en"}catch(t){return console.error(t),console.warn("Unexpected error while normalizing locale ".concat(e,", falling back to English.")),"en"}}(t.locales||this.options.locales,t.locale)),t=this.layoutEngine.setOptions(t.layout,t),this.canvas.setOptions(t),this.groups.setOptions(t.groups),this.nodesHandler.setOptions(t.nodes),this.edgesHandler.setOptions(t.edges),this.physics.setOptions(t.physics),this.manipulation.setOptions(t.manipulation,t,this.options),this.interactionHandler.setOptions(t.interaction),this.renderer.setOptions(t.interaction),this.selectionHandler.setOptions(t.interaction),void 0!==t.groups&&this.body.emitter.emit("refreshNodes"),"configure"in t&&(this.configurator||(this.configurator=new hl(this,this.body.container,zv,this.canvas.pixelRatio,Nv)),this.configurator.setOptions(t.configure)),this.configurator&&!0===this.configurator.options.enabled){var i={nodes:{},edges:{},layout:{},interaction:{},manipulation:{},physics:{},global:{}};Ch(i.nodes,this.nodesHandler.options),Ch(i.edges,this.edgesHandler.options),Ch(i.layout,this.layoutEngine.options),Ch(i.interaction,this.selectionHandler.options),Ch(i.interaction,this.renderer.options),Ch(i.interaction,this.interactionHandler.options),Ch(i.manipulation,this.manipulation.options),Ch(i.physics,this.physics.options),Ch(i.global,this.canvas.options),Ch(i.global,this.options),this.configurator.setModuleOptions(i)}void 0!==t.clickToUse?!0===t.clickToUse?void 0===this.activator&&(this.activator=new sl(this.canvas.frame),this.activator.on("change",(function(){e.body.emitter.emit("activate")}))):(void 0!==this.activator&&(this.activator.destroy(),delete this.activator),this.body.emitter.emit("activate")):this.body.emitter.emit("activate"),this.canvas.setSize(),this.body.emitter.emit("startSimulation")}},Rv.prototype._updateVisibleIndices=function(){var t=this.body.nodes,e=this.body.edges;for(var i in this.body.nodeIndices=[],this.body.edgeIndices=[],t)Object.prototype.hasOwnProperty.call(t,i)&&(this.clustering._isClusteredNode(i)||!1!==t[i].options.hidden||this.body.nodeIndices.push(t[i].id));for(var n in e)if(Object.prototype.hasOwnProperty.call(e,n)){var o=e[n],r=t[o.fromId],s=t[o.toId],a=void 0!==r&&void 0!==s;!this.clustering._isClusteredEdge(n)&&!1===o.options.hidden&&a&&!1===r.options.hidden&&!1===s.options.hidden&&this.body.edgeIndices.push(o.id)}},Rv.prototype.bindEventListeners=function(){var t=this;this.body.emitter.on("_dataChanged",(function(){t.edgesHandler._updateState(),t.body.emitter.emit("_dataUpdated")})),this.body.emitter.on("_dataUpdated",(function(){t.clustering._updateState(),t._updateVisibleIndices(),t._updateValueRange(t.body.nodes),t._updateValueRange(t.body.edges),t.body.emitter.emit("startSimulation"),t.body.emitter.emit("_requestRedraw")}))},Rv.prototype.setData=function(t){if(this.body.emitter.emit("resetPhysics"),this.body.emitter.emit("_resetData"),this.selectionHandler.unselectAll(),t&&t.dot&&(t.nodes||t.edges))throw new SyntaxError('Data must contain either parameter "dot" or  parameter pair "nodes" and "edges", but not both.');if(this.setOptions(t&&t.options),t&&t.dot){console.warn("The dot property has been deprecated. Please use the static convertDot method to convert DOT into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertDot(dotString);");var e=Ul(t.dot);this.setData(e)}else if(t&&t.gephi){console.warn("The gephi property has been deprecated. Please use the static convertGephi method to convert gephi into vis.network format and use the normal data format with nodes and edges. This converter is used like this: var data = vis.network.convertGephi(gephiJson);");var i=Xl(t.gephi);this.setData(i)}else this.nodesHandler.setData(t&&t.nodes,!0),this.edgesHandler.setData(t&&t.edges,!0),this.body.emitter.emit("_dataChanged"),this.body.emitter.emit("_dataLoaded"),this.body.emitter.emit("initPhysics")},Rv.prototype.destroy=function(){for(var t in this.body.emitter.emit("destroy"),this.body.emitter.off(),this.off(),delete this.groups,delete this.canvas,delete this.selectionHandler,delete this.interactionHandler,delete this.view,delete this.renderer,delete this.physics,delete this.layoutEngine,delete this.clustering,delete this.manipulation,delete this.nodesHandler,delete this.edgesHandler,delete this.configurator,delete this.images,this.body.nodes)Object.prototype.hasOwnProperty.call(this.body.nodes,t)&&delete this.body.nodes[t];for(var e in this.body.edges)Object.prototype.hasOwnProperty.call(this.body.edges,e)&&delete this.body.edges[e];mh(this.body.container)},Rv.prototype._updateValueRange=function(t){var e,i=void 0,n=void 0,o=0;for(e in t)if(Object.prototype.hasOwnProperty.call(t,e)){var r=t[e].getValue();void 0!==r&&(i=void 0===i?r:Math.min(r,i),n=void 0===n?r:Math.max(r,n),o+=r)}if(void 0!==i&&void 0!==n)for(e in t)Object.prototype.hasOwnProperty.call(t,e)&&t[e].setValueRange(i,n,o)},Rv.prototype.isActive=function(){return!this.activator||this.activator.active},Rv.prototype.setSize=function(){return this.canvas.setSize.apply(this.canvas,arguments)},Rv.prototype.canvasToDOM=function(){return this.canvas.canvasToDOM.apply(this.canvas,arguments)},Rv.prototype.DOMtoCanvas=function(){return this.canvas.DOMtoCanvas.apply(this.canvas,arguments)},Rv.prototype.findNode=function(){return this.clustering.findNode.apply(this.clustering,arguments)},Rv.prototype.isCluster=function(){return this.clustering.isCluster.apply(this.clustering,arguments)},Rv.prototype.openCluster=function(){return this.clustering.openCluster.apply(this.clustering,arguments)},Rv.prototype.cluster=function(){return this.clustering.cluster.apply(this.clustering,arguments)},Rv.prototype.getNodesInCluster=function(){return this.clustering.getNodesInCluster.apply(this.clustering,arguments)},Rv.prototype.clusterByConnection=function(){return this.clustering.clusterByConnection.apply(this.clustering,arguments)},Rv.prototype.clusterByHubsize=function(){return this.clustering.clusterByHubsize.apply(this.clustering,arguments)},Rv.prototype.updateClusteredNode=function(){return this.clustering.updateClusteredNode.apply(this.clustering,arguments)},Rv.prototype.getClusteredEdges=function(){return this.clustering.getClusteredEdges.apply(this.clustering,arguments)},Rv.prototype.getBaseEdge=function(){return this.clustering.getBaseEdge.apply(this.clustering,arguments)},Rv.prototype.getBaseEdges=function(){return this.clustering.getBaseEdges.apply(this.clustering,arguments)},Rv.prototype.updateEdge=function(){return this.clustering.updateEdge.apply(this.clustering,arguments)},Rv.prototype.clusterOutliers=function(){return this.clustering.clusterOutliers.apply(this.clustering,arguments)},Rv.prototype.getSeed=function(){return this.layoutEngine.getSeed.apply(this.layoutEngine,arguments)},Rv.prototype.enableEditMode=function(){return this.manipulation.enableEditMode.apply(this.manipulation,arguments)},Rv.prototype.disableEditMode=function(){return this.manipulation.disableEditMode.apply(this.manipulation,arguments)},Rv.prototype.addNodeMode=function(){return this.manipulation.addNodeMode.apply(this.manipulation,arguments)},Rv.prototype.editNode=function(){return this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.editNodeMode=function(){return console.warn("Deprecated: Please use editNode instead of editNodeMode."),this.manipulation.editNode.apply(this.manipulation,arguments)},Rv.prototype.addEdgeMode=function(){return this.manipulation.addEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.editEdgeMode=function(){return this.manipulation.editEdgeMode.apply(this.manipulation,arguments)},Rv.prototype.deleteSelected=function(){return this.manipulation.deleteSelected.apply(this.manipulation,arguments)},Rv.prototype.getPositions=function(){return this.nodesHandler.getPositions.apply(this.nodesHandler,arguments)},Rv.prototype.getPosition=function(){return this.nodesHandler.getPosition.apply(this.nodesHandler,arguments)},Rv.prototype.storePositions=function(){return this.nodesHandler.storePositions.apply(this.nodesHandler,arguments)},Rv.prototype.moveNode=function(){return this.nodesHandler.moveNode.apply(this.nodesHandler,arguments)},Rv.prototype.getBoundingBox=function(){return this.nodesHandler.getBoundingBox.apply(this.nodesHandler,arguments)},Rv.prototype.getConnectedNodes=function(t){return void 0!==this.body.nodes[t]?this.nodesHandler.getConnectedNodes.apply(this.nodesHandler,arguments):this.edgesHandler.getConnectedNodes.apply(this.edgesHandler,arguments)},Rv.prototype.getConnectedEdges=function(){return this.nodesHandler.getConnectedEdges.apply(this.nodesHandler,arguments)},Rv.prototype.startSimulation=function(){return this.physics.startSimulation.apply(this.physics,arguments)},Rv.prototype.stopSimulation=function(){return this.physics.stopSimulation.apply(this.physics,arguments)},Rv.prototype.stabilize=function(){return this.physics.stabilize.apply(this.physics,arguments)},Rv.prototype.getSelection=function(){return this.selectionHandler.getSelection.apply(this.selectionHandler,arguments)},Rv.prototype.setSelection=function(){return this.selectionHandler.setSelection.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedNodes=function(){return this.selectionHandler.getSelectedNodeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getSelectedEdges=function(){return this.selectionHandler.getSelectedEdgeIds.apply(this.selectionHandler,arguments)},Rv.prototype.getNodeAt=function(){var t=this.selectionHandler.getNodeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.getEdgeAt=function(){var t=this.selectionHandler.getEdgeAt.apply(this.selectionHandler,arguments);return void 0!==t&&void 0!==t.id?t.id:t},Rv.prototype.selectNodes=function(){return this.selectionHandler.selectNodes.apply(this.selectionHandler,arguments)},Rv.prototype.selectEdges=function(){return this.selectionHandler.selectEdges.apply(this.selectionHandler,arguments)},Rv.prototype.unselectAll=function(){this.selectionHandler.unselectAll.apply(this.selectionHandler,arguments),this.selectionHandler.commitWithoutEmitting.apply(this.selectionHandler),this.redraw()},Rv.prototype.redraw=function(){return this.renderer.redraw.apply(this.renderer,arguments)},Rv.prototype.getScale=function(){return this.view.getScale.apply(this.view,arguments)},Rv.prototype.getViewPosition=function(){return this.view.getViewPosition.apply(this.view,arguments)},Rv.prototype.fit=function(){return this.view.fit.apply(this.view,arguments)},Rv.prototype.moveTo=function(){return this.view.moveTo.apply(this.view,arguments)},Rv.prototype.focus=function(){return this.view.focus.apply(this.view,arguments)},Rv.prototype.releaseNode=function(){return this.view.releaseNode.apply(this.view,arguments)},Rv.prototype.getOptionsFromConfigurator=function(){var t={};return this.configurator&&(t=this.configurator.getOptions.apply(this.configurator)),t};var qv=Object.freeze({__proto__:null,prepareElements:Lv,cleanupElements:Hv,resetElements:function(t){Lv(t),Hv(t),Lv(t)},getSVGElement:Wv,getDOMElement:function(t,e,i,n){var o;return Object.prototype.hasOwnProperty.call(e,t)?e[t].redundant.length>0?(o=e[t].redundant[0],e[t].redundant.shift()):(o=document.createElement(t),void 0!==n?i.insertBefore(o,n):i.appendChild(o)):(o=document.createElement(t),e[t]={used:[],redundant:[]},void 0!==n?i.insertBefore(o,n):i.appendChild(o)),e[t].used.push(o),o},drawPoint:function(t,e,i,n,o,r){var s;if("circle"==i.style?((s=Wv("circle",n,o)).setAttributeNS(null,"cx",t),s.setAttributeNS(null,"cy",e),s.setAttributeNS(null,"r",.5*i.size)):((s=Wv("rect",n,o)).setAttributeNS(null,"x",t-.5*i.size),s.setAttributeNS(null,"y",e-.5*i.size),s.setAttributeNS(null,"width",i.size),s.setAttributeNS(null,"height",i.size)),void 0!==i.styles&&s.setAttributeNS(null,"style",i.styles),s.setAttributeNS(null,"class",i.className+" vis-point"),r){var a=Wv("text",n,o);r.xOffset&&(t+=r.xOffset),r.yOffset&&(e+=r.yOffset),r.content&&(a.textContent=r.content),r.className&&a.setAttributeNS(null,"class",r.className+" vis-label"),a.setAttributeNS(null,"x",t),a.setAttributeNS(null,"y",e)}return s},drawBar:function(t,e,i,n,o,r,s,a){if(0!=n){n<0&&(e-=n*=-1);var h=Wv("rect",r,s);h.setAttributeNS(null,"x",t-.5*i),h.setAttributeNS(null,"y",e),h.setAttributeNS(null,"width",i),h.setAttributeNS(null,"height",n),h.setAttributeNS(null,"class",o),a&&h.setAttributeNS(null,"style",a)}}}),Vv={Images:Zl,dotparser:Yl,gephiParser:Gl,allOptions:Av,convertDot:Ul,convertGephi:Xl},Uv=Object.freeze({__proto__:null,network:Vv,DOMutil:qv,util:fl,data:ou,Hammer:ll,keycharm:Tp,DataSet:tu,DataView:eu,Queue:Zc,Network:Rv});t.DOMutil=qv,t.DataSet=tu,t.DataView=eu,t.Hammer=ll,t.Network=Rv,t.Queue=Zc,t.data=ou,t.default=Uv,t.keycharm=Tp,t.network=Vv,t.util=fl,Object.defineProperty(t,"__esModule",{value:!0})}));
+//# sourceMappingURL=vis-network.min.js.map
+</script>
+<script>// Production steps of ECMA-262, Edition 6, 22.1.2.1
+// Référence : https://people.mozilla.org/~jorendorff/es6-draft.html#sec-array.from
+if (!Array.from) {
+  Array.from = (function () {
+    var toStr = Object.prototype.toString;
+    var isCallable = function (fn) { 
+      return typeof fn === 'function' || toStr.call(fn) === '[object Function]';
+    };
+    var toInteger = function (value) { 
+      var number = Number(value); 
+      if (isNaN(number)) { return 0; }
+      if (number === 0 || !isFinite(number)) { return number; }
+      return (number > 0 ? 1 : -1) * Math.floor(Math.abs(number)); 
+    };
+    var maxSafeInteger = Math.pow(2, 53) - 1;
+    var toLength = function (value) { 
+      var len = toInteger(value);
+      return Math.min(Math.max(len, 0), maxSafeInteger);
+    }; 
+  
+    // La propriété length de la méthode vaut 1.
+    return function from(arrayLike/*, mapFn, thisArg */) { 
+      // 1. Soit C, la valeur this
+      var C = this;
+      
+      // 2. Soit items le ToObject(arrayLike).
+      var items = Object(arrayLike); 
+      
+      // 3. ReturnIfAbrupt(items).
+      if (arrayLike == null) { 
+        throw new TypeError("Array.from doit utiliser un objet semblable à un tableau - null ou undefined ne peuvent pas être utilisés");
+      }
+    
+      // 4. Si mapfn est undefined, le mapping sera false.
+      var mapFn = arguments.length > 1 ? arguments[1] : void undefined;
+      var T;
+      if (typeof mapFn !== 'undefined') {  
+        // 5. sinon      
+        // 5. a. si IsCallable(mapfn) est false, on lève une TypeError.
+        if (!isCallable(mapFn)) { 
+          throw new TypeError('Array.from: lorsqu il est utilisé le deuxième argument doit être une fonction'); 
+        }
+     
+        // 5. b. si thisArg a été fourni, T sera thisArg ; sinon T sera undefined.
+        if (arguments.length > 2) { 
+          T = arguments[2];
+        }
+      }
+    
+      // 10. Soit lenValue pour Get(items, "length").
+      // 11. Soit len pour ToLength(lenValue).
+      var len = toLength(items.length);  
+     
+      // 13. Si IsConstructor(C) vaut true, alors
+      // 13. a. Soit A le résultat de l'appel à la méthode interne [[Construct]] avec une liste en argument qui contient l'élément len.
+      // 14. a. Sinon, soit A le résultat de ArrayCreate(len).
+      var A = isCallable(C) ? Object(new C(len)) : new Array(len);
+   
+      // 16. Soit k égal à 0.
+      var k = 0;  // 17. On répète tant que k < len… 
+      var kValue;
+      while (k < len) {
+        kValue = items[k]; 
+        if (mapFn) {
+          A[k] = typeof T === 'undefined' ? mapFn(kValue, k) : mapFn.call(T, kValue, k); 
+        } else {
+          A[k] = kValue;
+        }
+        k += 1;
+      }
+      // 18. Soit putStatus égal à Put(A, "length", len, true).
+      A.length = len;  // 20. On renvoie A.
+      return A;
+    };
+  }());
+};
+
+
+// https://tc39.github.io/ecma262/#sec-array.prototype.includes
+if (!Array.prototype.includes) {
+  Object.defineProperty(Array.prototype, 'includes', {
+    value: function(searchElement, fromIndex) {
+
+      if (this == null) {
+        throw new TypeError('"this" est nul ou non défini');
+      }
+
+      // 1. Soit o égal à ? Object(cette valeur).
+      var o = Object(this);
+
+      // 2. Soit len égal à ? Length(? Get(o, "length")).
+      var len = o.length >>> 0;
+
+      // 3. Si len = 0, renvoyer "false".
+      if (len === 0) {
+        return false;
+      }
+
+      // 4. Soit n = ? ToInteger(fromIndex).
+      // Pour la cohérence du code, on gardera le nom anglais "fromIndex" pour la variable auparavant appelée "indiceDépart"
+      //    (Si fromIndex n'est pas défini, cette étape produit la valeur 0.)
+      var n = fromIndex | 0;
+
+      // 5. Si n ≥ 0,
+      //  a. Alors k = n.
+      // 6. Sinon, si n < 0,
+      //  a. Alors k = len + n.
+      //  b. Si k < 0, alors k = 0.
+      var k = Math.max(n >= 0 ? n : len - Math.abs(n), 0);
+
+      function sameValueZero(x, y) {
+        return x === y || (typeof x === 'number' && typeof y === 'number' && isNaN(x) && isNaN(y));
+      }
+
+      // 7. Répéter tant que k < len
+      while (k < len) {
+        // a. Soit elementK le résultat de ? Get(O, ! ToString(k)).
+        // b. Si SameValueZero(searchElement, elementK) est vrai, renvoyer "true".
+        if (sameValueZero(o[k], searchElement)) {
+          return true;
+        }
+        // c. Augmenter la valeur de k de 1. 
+        k++;
+      }
+
+      // 8. Renvoyer "false"
+      return false;
+    }
+  });
+}
+
+// Add shim for Function.prototype.bind() from:
+// https://developer.mozilla.org/en-US/docs/JavaScript/Reference/Global_Objects/Function/bind#Compatibility
+// for fix some RStudio viewer bug (Desktop / windows)
+if (!Function.prototype.bind) {
+  Function.prototype.bind = function (oThis) {
+    if (typeof this !== "function") {
+      // closest thing possible to the ECMAScript 5 internal IsCallable function
+      throw new TypeError("Function.prototype.bind - what is trying to be bound is not callable");
+    }
+    
+    var aArgs = Array.prototype.slice.call(arguments, 1),
+    fToBind = this,
+    fNOP = function () {},
+    fBound = function () {
+      return fToBind.apply(this instanceof fNOP && oThis
+                           ? this
+                           : oThis,
+                           aArgs.concat(Array.prototype.slice.call(arguments)));
+    };
+    
+    fNOP.prototype = this.prototype;
+    fBound.prototype = new fNOP();
+    
+    return fBound;
+  };
+}
+
+//--------------------------------------------
+// functions to reset edges after hard to read
+//--------------------------------------------
+
+// for edges
+function edgeAsHardToRead(edge, hideColor1, hideColor2, network, type){
+  //console.info("edgeAsHardToRead")
+  
+  if(type === "edge"){
+    //console.info("edge")
+    //console.info(edge.id)
+    
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  } else {
+    //console.info("cluster")
+    //console.info(edge.id)
+    //console.info(edge)
+    // saving color information (if we have)
+    if (edge.hiddenColor === undefined && edge.color !== hideColor1 && edge.color !== hideColor2) {
+      //network.clustering.updateEdge(edge.id, {hiddenColor : edge.color});
+      edge.hiddenColor = edge.color;
+    }
+    // set "hard to read" color
+    edge.color = hideColor1;
+    //network.clustering.updateEdge(edge.id, {color : hideColor1});
+    //edge.color = hideColor1;
+    // reset and save label
+    if (edge.hiddenLabel === undefined) {
+      edge.hiddenLabel = edge.label;
+      edge.label = undefined;
+    }
+    edge.isHardToRead = true;
+  }
+
+}
+
+function resetOneEdge(edge, hideColor1, hideColor2, type){
+  
+  /*console.info("resetOneEdge")
+  console.info(type)
+  console.info(edge.id) 
+  console.info(edge)
+  console.info("edge.hiddenColor")
+  console.info(edge.hiddenColor)*/
+  
+  var treat_egde = false;
+  if(type === "cluster"){
+    if(edge.isHardToRead !== undefined){ // we have to reset this node
+      if(edge.isHardToRead){
+        treat_egde = true;
+      } else if(edge.isHardToRead === false && (edge.color.color === hideColor1 || edge.color.color === hideColor2)){
+        treat_egde = true;
+      }
+    } else if(edge.color.color === hideColor1 || edge.color.color === hideColor2){
+      treat_egde = true;
+    }
+    
+    if(treat_egde){
+      // get back color
+      if (edge.hiddenColor !== undefined) {
+        edge.color = edge.hiddenColor;
+        edge.hiddenColor = undefined;
+      }else{
+        delete edge.color;
+      }
+        
+      // finally, get back label
+      if (edge.hiddenLabel !== undefined) {
+        edge.label = edge.hiddenLabel;
+        edge.hiddenLabel = undefined;
+      }
+      edge.isHardToRead = false;
+    }
+  } else {
+    // get back color
+    if (edge.hiddenColor !== undefined) {
+      edge.color = edge.hiddenColor;
+      edge.hiddenColor = undefined;
+    }else{
+      edge.color = null;
+    }
+    
+    // finally, get back label
+    if (edge.hiddenLabel !== undefined) {
+      edge.label = edge.hiddenLabel;
+      edge.hiddenLabel = undefined;
+    }
+    edge.isHardToRead = false;
+  }
+}
+
+function resetAllEdges(edges, hideColor1, hideColor2, network){
+  
+  var edgesToReset = edges.get({
+    fields: ['id', 'color', 'hiddenColor', 'label', 'hiddenLabel'],
+    filter: function (item) {
+      return item.isHardToRead === true;
+    },
+    returnType :'Array'
+  });
+
+  var is_cluster_edges = false;
+  var edges_in_clusters;
+  if(network !== undefined){
+    edges_in_clusters = network.body.modules.clustering.clusteredEdges;
+    if(Object.keys(edges_in_clusters).length > 0){
+      is_cluster_edges = true;
+      edges_in_clusters = Object.keys(edges_in_clusters);
+    } else {
+      edges_in_clusters = [];
+    }
+  }
+  
+  var treat_edges_in_clusters = [];
+  // all edges get their own color and their label back
+  for (var i = 0; i < edgesToReset.length; i++) {
+    resetOneEdge(edgesToReset[i], hideColor1, hideColor2,type = "edge");
+    if(is_cluster_edges){
+      if(indexOf.call(edges_in_clusters, edgesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.getClusteredEdges(edgesToReset[i].id);
+        if(tmp_cluster_id.length > 1){
+          tmp_cluster_id = tmp_cluster_id[0];
+          treat_edges_in_clusters.push(tmp_cluster_id);
+          resetOneEdge(network.body.edges[tmp_cluster_id].options, hideColor1, hideColor2, type = "cluster");
+        }
+      }
+    }
+  }
+  
+  // some misunderstood bug on some cluster edges... so have a (bad) fix...
+  var edges_in_clusters_ctrl = edges_in_clusters.filter(function(word,index){
+    if(word.match(/^clusterEdge/i)){
+      if(indexOf.call(treat_edges_in_clusters, word, true) === -1){
+        return true;
+      } else {
+        return false;
+      }
+        
+    }else{
+        return false;
+    }
+  });
+  
+  if(is_cluster_edges){
+    if(edges_in_clusters_ctrl.length > 0){
+       for (var j = 0; j < edges_in_clusters_ctrl.length; j++) {
+         if(network.body.edges[edges_in_clusters_ctrl[j]] !== undefined){
+           resetOneEdge(network.body.edges[edges_in_clusters_ctrl[j]].options, hideColor1, hideColor2, type = "cluster");
+         }
+        }
+    }
+  }
+
+  edges.update(edgesToReset);
+}
+
+//--------------------------------------------
+// functions to reset nodes after hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleResetNode(node, type){
+  if(type === "node"){
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2){
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for icon node
+function simpleIconResetNode(node, type){
+  if(type === "node"){  
+    // icon color
+    node.icon.color = node.hiddenColor;
+    node.hiddenColor = undefined;
+    // get back color
+    if (node.hiddenColorForLabel !== undefined) {
+      node.color = node.hiddenColorForLabel;
+      node.hiddenColorForLabel = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+  } else {
+    node.setOptions({icon : { color : node.options.hiddenColor}, hiddenColor : undefined});
+    if (node.options.hiddenColorForLabel !== undefined) {
+      node.setOptions({color : node.options.hiddenColorForLabel, hiddenColorForLabel : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+  }
+}
+
+// for image node
+function simpleImageResetNode(node, imageType, type){
+  if(type === "node"){  
+    // get back color
+    if (node.hiddenColor !== undefined) {
+      node.color = node.hiddenColor;
+      node.hiddenColor = undefined;
+    }else{
+      if(node.group !== undefined){
+        node.color = undefined;
+      } else {
+        node.color = null;
+      }
+    }
+    // and set shape as image/circularImage
+    node.shape = imageType;
+  } else {
+    if (Object.keys(node.options.hiddenColor).length > 2) {
+      node.setOptions({color : node.options.hiddenColor, hiddenColor : undefined});
+    }else{
+      if(node.options.group !== undefined){
+        node.setOptions({color : undefined});
+      } else {
+        node.setOptions({color : null});
+      }
+    }
+    node.setOptions({shape : imageType});
+  }
+}
+
+// Global function to reset one cluster
+function resetOneCluster(node, options, network){
+  if(node !== undefined){
+    if(node.options.isHardToRead !== undefined){ // we have to reset this node
+      if(node.options.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.options.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.options.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.options.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.options.hiddenImage !== undefined){
+          final_shape = node.options.hiddenImage;
+        } else if(node.options.shape !== undefined){
+          final_shape = node.options.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.options.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        node.setOptions({bodyHiddenColor : network.body.nodes[node.id].options.color});
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "cluster");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "cluster");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "cluster");
+        } else {
+          simpleResetNode(node, "cluster");
+        }
+    	 // finally, get back label
+        if (node.options.hiddenLabel !== undefined) {
+          node.setOptions({label : node.options.hiddenLabel, hiddenLabel : undefined});
+        }
+        node.options.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset one node
+function resetOneNode(node, options, network){
+  if(node !== undefined){
+    if(node.isHardToRead !== undefined){ // we have to reset this node
+      if(node.isHardToRead){
+        var final_shape;
+        var shape_group = false;
+        var is_group = false;
+  	  // have a group information & a shape defined in group ?
+        if(node.group !== undefined && options.groups !== undefined){
+          if(options.groups[node.group] !== undefined){
+            is_group = true;
+            if(options.groups[node.group].shape !== undefined){
+              shape_group = true;
+            }
+          }
+        }
+        // have a global shape in nodes options ?
+        var shape_options = false;
+        if(options.nodes !== undefined){
+          if(options.nodes.shape !== undefined){
+            shape_options = true;
+          }
+        }
+        // set final shape (individual > group > global)
+        if(node.hiddenImage !== undefined){
+          final_shape = node.hiddenImage;
+        } else if(node.shape !== undefined){
+          final_shape = node.shape;
+        } else if(shape_group){
+          final_shape = options.groups[node.group].shape;
+        } else if(shape_options){
+          final_shape = options.nodes.shape;
+        }
+        
+        // reset body information
+        network.body.nodes[node.id].options.color = node.bodyHiddenColor;
+
+        // and call good reset function
+        if(final_shape === "icon"){
+          simpleIconResetNode(node, "node");
+        } else if(final_shape === "image"){
+          simpleImageResetNode(node, "image", "node");
+        } else if(final_shape === "circularImage"){
+          simpleImageResetNode(node, "circularImage", "node");
+        } else {
+          simpleResetNode(node, "node");
+        }
+    	 // finally, get back label
+    	  if (node.hiddenLabel !== undefined) {
+          node.label = node.hiddenLabel;
+          node.hiddenLabel = undefined;
+        }
+        node.isHardToRead = false;
+      }
+    }
+  }
+}
+
+// Global function to reset all node
+function resetAllNodes(nodes, update, options, network, all){
+  
+  if(all === false){
+      var nodesToReset = nodes.get({
+      filter: function (item) {
+        return item.isHardToRead === true;
+      },
+      returnType :'Array'
+    });
+  } else {
+      var nodesToReset = nodes.get({returnType :'Array'});
+  }
+  
+  var have_cluster_nodes = false;
+  var nodes_in_clusters;
+  if(network !== undefined){
+    nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+    if(Object.keys(nodes_in_clusters).length > 0){
+      have_cluster_nodes = true;
+      nodes_in_clusters = Object.keys(nodes_in_clusters);
+    } else {
+      nodes_in_clusters = [];
+    }
+  }
+
+  for (var i = 0; i < nodesToReset.length; i++) {
+    resetOneNode(nodesToReset[i], options, network, type = "node");
+	// reset coordinates
+    nodesToReset[i].x = undefined;
+    nodesToReset[i].y = undefined;
+    if(have_cluster_nodes){
+      if(indexOf.call(nodes_in_clusters, nodesToReset[i].id, true) > -1){
+        var tmp_cluster_id = network.clustering.findNode(nodesToReset[i].id);
+        // in case of multiple cluster...
+        for(var j = 0; j < (tmp_cluster_id.length-1); j++) {
+          resetOneCluster(network.body.nodes[tmp_cluster_id[j]], options, network);
+        }
+      }
+    }
+  }
+  if(update){
+    nodes.update(nodesToReset);
+  }
+}
+
+//--------------------------------------------
+// functions to set nodes as hard to read
+//--------------------------------------------
+
+// for classic node
+function simpleNodeAsHardToRead(node, hideColor1, hideColor2, type){
+
+
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+  
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  // cluster  
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label});
+      node.setOptions({label : undefined});
+    }
+  }
+}
+
+// for icon node
+function iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type){
+  // classic nodes
+  if(type === "node"){
+    // individual information
+    if(node.icon !== undefined && node.icon !== null && node.icon !== {}){
+      node.iconDefined = true;
+    } else { // information in group : have to as individual
+      node.icon = {};
+      node.iconDefined = false;
+    }
+    // set "hard to read" color
+    node.icon.color = hideColor1;
+    node.hiddenColor = icon_color;
+    // for edges....saving color information (if we have)
+    if (node.hiddenColorForLabel === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColorForLabel = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+  } else {
+    // individual information
+    if(node.options.icon !== undefined && node.options.icon !== null && node.options.icon !== {}){
+      node.setOptions({iconDefined : true});
+    } else { // information in group : have to as individual
+      node.setOptions({iconDefined : false, icon:{}});
+    }
+    // set "hard to read" color
+    node.setOptions({hiddenColor : icon_color, icon:{color : hideColor1}});
+    // for edges....saving color information (if we have)
+    if (node.options.hiddenColorForLabel === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColorForLabel : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+  }
+}
+
+// for image node
+function imageNodeAsHardToRead(node, imageType, hideColor1, hideColor2, type){
+  // classic nodes
+  if(type === "node"){
+    // saving color information (if we have)
+    if (node.hiddenColor === undefined && node.color !== hideColor1 && node.color !== hideColor2) {
+      node.hiddenColor = node.color;
+    }
+    // set "hard to read" color
+    node.color = hideColor1;
+    // reset and save label
+    if (node.hiddenLabel === undefined) {
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    }
+    // keep shape information, and set a new
+    if(imageType === "image"){
+      node.hiddenImage = imageType;
+      node.shape = "square";
+    }else if(imageType === "circularImage"){
+      node.hiddenImage = imageType;
+      node.shape = "dot";
+    }
+  } else {
+    // saving color information (if we have)
+    if (node.options.hiddenColor === undefined && node.options.color !== hideColor1 && node.options.color !== hideColor2) {
+      node.setOptions({hiddenColor : node.options.color});
+    }
+    // set "hard to read" color
+    node.setOptions({color : hideColor1});
+    // reset and save label
+    if (node.options.hiddenLabel === undefined) {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined});
+    }
+    if(imageType === "image"){
+      node.setOptions({hiddenImage : "image", shape : "square"});
+    } else if(imageType === "circularImage"){
+      node.setOptions({hiddenImage : "circularImage", shape : "dot"});
+    }
+    node.hiddenImage = imageType;
+  }
+}
+
+// Global function to set one node as hard to read
+function nodeAsHardToRead(node, options, hideColor1, hideColor2, network, type){
+  var final_shape;
+  var shape_group = false;
+  var is_group = false;
+
+
+  if(node.isHardToRead === false || node.isHardToRead === undefined){
+
+    // have a group information & a shape defined in group ?
+    if(node.group !== undefined && options.groups !== undefined){
+      if(options.groups[node.group] !== undefined){
+        is_group = true;
+        if(options.groups[node.group].shape !== undefined){
+          shape_group = true;
+        }
+      }
+    }
+    // have a group information & a shape defined in group ?
+    var shape_options = false;
+    if(options.nodes !== undefined){
+      if(options.nodes.shape !== undefined){
+        shape_options = true;
+      }
+    }
+    // set final shape (individual > group > global)
+    if(node.shape !== undefined){
+      final_shape = node.shape;
+    } else if(shape_group){
+      final_shape = options.groups[node.group].shape;
+    } else if(shape_options){
+      final_shape = options.nodes.shape;
+    }
+    
+    // information save in body nodes
+    if(type === "node"){
+      node.bodyHiddenColor = clone(network.body.nodes[node.id].options.color);
+    } else {
+      node.setOptions({bodyHiddenColor : clone(network.body.nodes[node.id].options.color)});
+    }
+  
+    // and call good function
+    if(final_shape === "icon"){
+      // find color for icon
+      var icon_color = "#2B7CE9";
+      var find_color = false;
+      // in nodes ?
+      if(node.icon !== undefined){
+        if(node.icon.color !== undefined){
+          icon_color = node.icon.color;
+          find_color = true;
+        }
+      } 
+      // or in group ?
+      if(find_color === false && is_group && options.groups !== undefined && options.groups[node.group].icon !== undefined){
+        if(options.groups[node.group].icon.color !== undefined){
+          icon_color = options.groups[node.group].icon.color;
+          find_color = true;
+        }
+      }
+      // in global node ?
+      if(find_color === false && options.nodes.icon !== undefined){
+        if(options.nodes.icon.color !== undefined){
+          icon_color = options.nodes.icon.color;
+        }
+      } 
+      iconsNodeAsHardToRead(node, hideColor1, hideColor2, icon_color, type);
+    } else if(final_shape === "image"){
+      imageNodeAsHardToRead(node, "image", hideColor1, hideColor2, type);
+    } else if(final_shape === "circularImage"){
+      imageNodeAsHardToRead(node, "circularImage", hideColor1, hideColor2, type);
+    } else {
+      simpleNodeAsHardToRead(node, hideColor1, hideColor2, type);
+    }
+    
+    // finally set isHardToRead
+    if(type === "node"){
+      node.isHardToRead = true;
+    } else {
+      node.setOptions({isHardToRead : true});
+    }
+  // special case of just to label  
+  } else if(node.isHardToRead === true && node.label !== undefined){
+    if(type === "node"){
+      node.hiddenLabel = node.label;
+      node.label = undefined;
+    } else {
+      node.setOptions({hiddenLabel : node.options.label, label : undefined})
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Revrite HTMLWidgets.dataframeToD3() for passing custom
+// properties directly in data.frame (color.background) for example
+//----------------------------------------------------------------
+function visNetworkdataframeToD3(df, type) {
+
+  // variables we have specially to control
+  /*var nodesctrl = ["color", "fixed", "font", "icon", "shadow", "scaling", "shapeProperties", "chosen", "heightConstraint", "image", "margin", "widthConstraint"];
+  var edgesctrl = ["color", "font", "arrows", "shadow", "smooth", "scaling", "chosen", "widthConstraint"];*/
+  
+  var names = [];
+  var colnames = [];
+  var length;
+  var toctrl;
+  var ctrlname;
+  
+  for (var name in df) {
+    if (df.hasOwnProperty(name))
+      colnames.push(name);
+      ctrlname = name.split(".");
+      if(ctrlname.length === 1){
+        names.push( new Array(name));
+      } else {
+        /*if(type === "nodes"){
+         toctrl = indexOf.call(nodesctrl, ctrlname[0], true);
+        } else if(type === "edges"){
+         toctrl = indexOf.call(edgesctrl, ctrlname[0], true);
+        }
+        if(toctrl > -1){*/
+          names.push(ctrlname);
+        /*} else {
+          names.push(new Array(name));
+        }*/
+      }
+      if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+          throw new Error("All fields must be arrays");
+      } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+          throw new Error("All fields must be arrays of the same length");
+      }
+      length = df[name].length;
+  }
+
+  var results = [];
+  var item;
+    for (var row = 0; row < length; row++) {
+      item = {};
+      for (var col = 0; col < names.length; col++) {
+        if(df[colnames[col]][row] !== null){
+          if(names[col].length === 1){
+            if(names[col][0] === "dashes"){
+              item[names[col]] = eval(df[colnames[col]][row]);
+            } else {
+              item[names[col]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 2){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(names[col][0] === "icon" && names[col][1] === "code"){
+              item[names[col][0]][names[col][1]] = JSON.parse( '"'+'\\u' + df[colnames[col]][row] + '"');
+            } else if(names[col][0] === "icon" && names[col][1] === "color"){
+              item.color = df[colnames[col]][row];
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else if(names[col][0] === "icon" && names[col][1] === "face"){
+              if(df[colnames[col]][row] === "'Font Awesome 5 Free'"){
+                item.icon.weight = "bold";
+              }
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            } else{
+              item[names[col][0]][names[col][1]] = df[colnames[col]][row];
+            }
+          } else if(names[col].length === 3){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]] = df[colnames[col]][row];
+          } else if(names[col].length === 4){
+            if(item[names[col][0]] === undefined){
+              item[names[col][0]] = {};
+            }
+            if(item[names[col][0]][names[col][1]] === undefined){
+              item[names[col][0]][names[col][1]] = {};
+            }
+            if(item[names[col][0]][names[col][1]][names[col][2]] === undefined){
+              item[names[col][0]][names[col][1]][names[col][2]] = {};
+            }
+            item[names[col][0]][names[col][1]][names[col][2]][names[col][3]] = df[colnames[col]][row];
+          }
+        }
+      }
+      results.push(item);
+    }
+  return results;
+}
+
+//----------------------------------------------------------------
+// Some utils functions
+//---------------------------------------------------------------- 
+
+//unique element in array
+function uniqueArray(arr, exclude_cluster, network) {
+  var a = [];
+  for (var i=0, l=arr.length; i<l; i++){
+    if (a.indexOf(arr[i]) === -1 && arr[i] !== ''){
+      if(exclude_cluster === false){
+        a.push(arr[i]);
+      } else if(network.isCluster(arr[i]) === false){
+        a.push(arr[i]);
+      }
+    }
+  }
+
+  return a;
+}
+
+function uniqueShiny(arr) {
+  return arr.filter(function (value, index, self) { 
+    return self.indexOf(value) === index;
+  });
+};
+// clone an object
+function clone(obj) {
+    if(obj === null || typeof(obj) != 'object')
+        return obj;    
+    var temp = new obj.constructor(); 
+    for(var key in obj)
+        temp[key] = clone(obj[key]);    
+    return temp;
+}
+// update a list
+function update(source, target) {
+	Object.keys(target).forEach(function (k) {
+		if (typeof target[k] === 'object' && k !== "container") {
+			source[k] = source[k] || {};
+			update(source[k], target[k]);
+		} else {
+			source[k] = target[k];
+		}
+	});
+}
+// for find element
+function indexOf(needle, str) {
+        indexOf = function(needle, str) {
+            var i = -1, index = -1;
+            if(str){
+                  needle = ''+needle;
+            }
+            for(i = 0; i < this.length; i++) {
+                var val = this[i];
+                if(str){
+                  val = ''+val;
+                }
+                if(val === needle) {
+                    index = i;
+                    break;
+                }
+            }
+            return index;
+        };
+    return indexOf.call(this, needle, str);
+};
+// reset a html list
+function resetList(list_name, id, shiny_input_name) {
+  var list = document.getElementById(list_name + id);
+  list.value = "";
+  if (window.Shiny){
+    Shiny.onInputChange(id + '_' + shiny_input_name, "");
+  }
+}
+// id node list selection init
+function setNodeIdList(selectList, params, nodes){
+  if(params.style !== undefined){
+    selectList.setAttribute('style', params.style);
+  }
+  selectList.style.display = 'inline';
+      
+  option = document.createElement("option");
+  option.value = "";
+  if(params.main === undefined){
+    option.text = "Select by id";
+  } else {
+    option.text = params.main;
+  }
+  
+  selectList.appendChild(option);
+      
+  // have to set for all nodes ?
+  if(params.values === undefined){
+    var info_node_list = nodes.get({
+      fields: ['id', 'label'],
+      returnType :'Array'
+    });
+    for (var i = 0; i < info_node_list.length; i++) {
+      option = document.createElement("option");
+      option.value = info_node_list[i].id;
+      if(info_node_list[i].label && params.useLabels){
+        option.text = info_node_list[i].label;
+      }else{
+        option.text = info_node_list[i].id;
+      }
+      selectList.appendChild(option);
+    }
+  } else {
+    var tmp_node;
+    for(var tmp_id = 0 ; tmp_id < params.values.length; tmp_id++){
+      tmp_node = nodes.get({
+        fields: ['id', 'label'],
+        filter: function (item) {
+          return (item.id === params.values[tmp_id]) ;
+        },
+        returnType :'Array'
+      });
+      if(tmp_node !== undefined){
+        option = document.createElement("option");
+        option.value = tmp_node[0].id;
+        if(tmp_node[0].label && params.useLabels){
+          option.text = tmp_node[0].label;
+        }else{
+          option.text = tmp_node[0].id;
+        }
+        selectList.appendChild(option);
+      }
+    }
+  }
+}
+
+//----------------------------------------------------------------
+// Collapsed function
+//---------------------------------------------------------------- 
+
+function networkOpenCluster(params){
+  if (params.nodes.length === 1) {
+    if (this.isCluster(params.nodes[0]) === true) {
+      var elid = this.body.container.id.substring(5);
+      var fit = document.getElementById(elid).collapseFit;
+      var resetHighlight = document.getElementById(elid).collapseResetHighlight;
+      
+      if(document.getElementById(elid).collapseKeepCoord){
+        this.openCluster(params.nodes[0], 
+        {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }
+        });
+      } else {
+        this.openCluster(params.nodes[0]);
+      }
+
+      
+      if(resetHighlight){
+        document.getElementById("nodeSelect"+elid).value = "";
+        document.getElementById("nodeSelect"+elid).onchange();
+      }
+      if(fit){
+        this.fit();
+      }
+    }
+  }
+}
+
+function collapsedNetwork(nodes, fit, resetHighlight, clusterParams, labelSuffix, treeParams, network, elid) {
+  
+  var set_position = true;
+  var selectedNode;
+  var j;
+  
+  if(nodes[0] !== undefined){
+    
+    for (var inodes = 0; inodes < nodes.length; inodes++) {
+      
+      selectedNode = nodes[inodes];
+      if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          //network.openCluster(selectedNode)
+          /*instance.network.openCluster(selectedNode, 
+          {releaseFunction : function(clusterPosition, containedNodesPositions) {
+            return tmp_position;
+          }})*/
+          //networkOpenCluster(selectedNode)
+        } else {
+          var firstLevelNodes = [];
+          var otherLevelNodes = [];
+          var connectedToNodes = [];
+      
+          item = network.body.data.nodes.get({
+            filter: function (item) {
+              return item.id == selectedNode;
+            }
+          });
+            
+          connectedToNodes = network.body.data.edges.get({
+          fields: ['id','to'],
+            filter: function (item) {
+              return item.from == selectedNode;
+            },
+            returnType :'Array'
+          });
+          
+          
+          
+          for (j = 0; j < connectedToNodes.length; j++) {
+            firstLevelNodes = firstLevelNodes.concat(connectedToNodes[j].to);
+          }
+    
+          var currentConnectedToNodes = firstLevelNodes;
+          while(currentConnectedToNodes.length !== 0){
+            connectedToNodes = network.body.data.edges.get({
+              fields: ['id', 'to'],
+                filter: function (item) {
+                  return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                },
+                returnType :'Array'
+            });
+                
+            currentConnectedToNodes = [];
+            var currentlength = otherLevelNodes.length;
+            for (j = 0; j < connectedToNodes.length; j++) {
+              otherLevelNodes = uniqueArray(otherLevelNodes.concat(connectedToNodes[j].to), false, network);
+              currentConnectedToNodes = uniqueArray(currentConnectedToNodes.concat(connectedToNodes[j].to), false, network);
+            }
+            if (otherLevelNodes.length === currentlength) { break; }
+          }
+              
+          var finalFirstLevelNodes = [];
+          for (j = 0; j < firstLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(firstLevelNodes[j])
+            if(findnode.length === 1){
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(firstLevelNodes[j]);
+            } else {
+              finalFirstLevelNodes = finalFirstLevelNodes.concat(findnode[0]);
+            }
+          }
+          
+          var finalClusterNodes = [];
+          for (j = 0; j < otherLevelNodes.length; j++) {
+            var findnode = network.clustering.findNode(otherLevelNodes[j])
+            if(findnode.length === 1){
+              finalClusterNodes = finalClusterNodes.concat(otherLevelNodes[j]);
+            } else {
+              finalClusterNodes = finalClusterNodes.concat(findnode[0]);
+            }
+          }
+
+          if(set_position){ 
+            network.storePositions();
+          }
+    
+          var clusterOptions = {
+            joinCondition: function (nodesOptions) {
+              return nodesOptions.id === selectedNode || indexOf.call(finalFirstLevelNodes, nodesOptions.id, true) > -1 || 
+                  indexOf.call(finalClusterNodes, nodesOptions.id, true) > -1; 
+              },
+              processProperties: function(clusterOptions, childNodes) {
+                var click_node = network.body.data.nodes.get({
+                  filter: function (item) {
+                    return item.id == selectedNode;
+                  },
+                  returnType :'Array'
+                });
+                
+                var is_hard_to_read = false;
+                if(click_node[0].isHardToRead !== undefined){
+                  is_hard_to_read = click_node[0].isHardToRead;
+                }
+                
+                for (var i in click_node[0]) {
+                  if(i !== "id" && i !== "isHardToRead"){
+                    if(i === "label" && is_hard_to_read){
+                      clusterOptions[i]=  click_node[0]["hiddenLabel"];
+                    } else if(i === "color" && is_hard_to_read) {
+                      clusterOptions[i]=  click_node[0]["hiddenColor"];
+                    } else {
+                       clusterOptions[i]=  click_node[0][i];
+                    }
+                  }
+                }
+                        
+                // gestion des tree
+                if(treeParams !== undefined){
+                  if(treeParams.updateShape){
+                    clusterOptions.label = clusterOptions.labelClust
+                    clusterOptions.color = clusterOptions.colorClust
+                    clusterOptions.shape = treeParams.shapeY
+                  }
+                }
+                        
+                if(clusterOptions.label !== undefined){
+                  clusterOptions.label = clusterOptions.label + " " + labelSuffix;
+                } else {
+                  clusterOptions.label =  labelSuffix;
+                }
+                        
+                if(clusterOptions.borderWidth !== undefined){
+                  clusterOptions.borderWidth = clusterOptions.borderWidth * 3;
+                } else {
+                  clusterOptions.borderWidth =  3;
+                }
+                        
+                if(set_position){
+                  if(click_node[0].x !== undefined){
+                    clusterOptions.x = click_node[0].x;
+                  }
+                  if(click_node[0].y !== undefined){
+                    clusterOptions.y = click_node[0].y;
+                  }
+                }
+                      
+                if(clusterParams !== undefined){
+                  for (var j in clusterParams) {
+                    clusterOptions[j]=  clusterParams[j];
+                  }
+                }
+                    
+              return clusterOptions;
+            },
+            clusterNodeProperties: {
+              allowSingleNodeCluster: false
+            }
+          }
+          network.cluster(clusterOptions);
+        }
+      }
+      
+    }
+    if(resetHighlight){
+      document.getElementById("nodeSelect"+elid).value = "";
+      document.getElementById("nodeSelect"+elid).onchange();
+    }
+    if(fit){
+      network.fit();
+    }
+  }
+};
+
+function uncollapsedNetwork(nodes, fit, resetHighlight, keepCoord, network, elid) {
+  var selectedNode;
+  var j;
+  var arr_nodes = [];
+  var cluster_node;
+  
+  var nodes_in_clusters = network.body.modules.clustering.clusteredNodes;
+  if(Object.keys(nodes_in_clusters).length > 0){
+    nodes_in_clusters = Object.keys(nodes_in_clusters);
+  } else {
+    nodes_in_clusters = []
+  }
+    
+  if(nodes !== undefined && nodes !== null){
+    arr_nodes = nodes
+  } else {
+    arr_nodes = nodes_in_clusters;
+  }
+
+  for (var inodes = 0; inodes < arr_nodes.length; inodes++) {
+    selectedNode = '' + arr_nodes[inodes];
+    if(selectedNode !== undefined){
+        if(network.isCluster(selectedNode)){
+          if(keepCoord){
+            network.openCluster(selectedNode, 
+              {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                    return containedNodesPositions;
+                  }
+              });
+          } else {
+            network.openCluster(selectedNode)
+          }
+        } else {
+          if(indexOf.call(nodes_in_clusters, selectedNode, true) > -1){
+            // not a cluster into a cluster...
+            if(selectedNode.search(/^cluster/i) === -1){
+              cluster_node = network.clustering.findNode(selectedNode)[0];
+              if(network.isCluster(cluster_node)){
+                if(keepCoord){
+                  network.openCluster(cluster_node, 
+                    {releaseFunction : function(clusterPosition, containedNodesPositions) {
+                          return containedNodesPositions;
+                        }
+                    });
+                } else {
+                  network.openCluster(cluster_node)
+                }
+              }
+            }
+          }
+        } 
+      }
+    }
+  if(resetHighlight){
+    document.getElementById("nodeSelect"+elid).value = "";
+    document.getElementById("nodeSelect"+elid).onchange();
+  }
+  if(fit){
+    network.fit();
+  }
+};
+
+//----------------------------------------------------------------
+// All available functions/methods with visNetworkProxy
+//--------------------------------------------------------------- 
+if (HTMLWidgets.shinyMode){
+  
+  // collapsed method
+  Shiny.addCustomMessageHandler('visShinyCollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        collapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.clusterOptions, data.labelSuffix, undefined, el.chart, data.id)
+      }
+  });
+  
+  // uncollapsed method
+  Shiny.addCustomMessageHandler('visShinyUncollapse', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        uncollapsedNetwork(data.nodes, data.fit, data.resetHighlight, data.keepCoord, el.chart, data.id)
+      }
+  });
+
+  // event method
+  Shiny.addCustomMessageHandler('visShinyEvents', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        if(data.type === "once"){
+          for (var key in data.events) {
+            eval('network.once("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "on"){
+          for (var key in data.events) {
+            eval('network.on("' + key + '",' + data.events[key] + ')');
+          }
+        } else if(data.type === "off"){
+          for (var key in data.events) {
+            eval('network.off("' + key + '",' + data.events[key] + ')');
+          }
+        }
+      }
+  });
+  
+  // moveNode method
+  Shiny.addCustomMessageHandler('visShinyMoveNode', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.moveNode(data.nodeId, data.x, data.y);
+      }
+  });
+  
+  // unselectAll method
+  Shiny.addCustomMessageHandler('visShinyUnselectAll', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        
+        // reset selection
+        document.getElementById("nodeSelect"+data.id).value = "";
+        document.getElementById("nodeSelect"+data.id).onchange();
+        
+        if(document.getElementById(data.id).selectActive === true){
+            document.getElementById("selectedBy"+data.id).value = "";
+            document.getElementById("selectedBy"+data.id).onchange();
+        }
+        
+        network.unselectAll();
+      }
+  });
+  
+  // updateOptions in the network
+  Shiny.addCustomMessageHandler('visShinyOptions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      
+      if(el){
+        var network = el.chart;
+        var options = el.options;
+        // configure
+        if(data.options.configure !== undefined){
+          if(data.options.configure.container !== undefined){
+            var dom_conf = document.getElementById(data.options.configure.container);
+            if(dom_conf !== null){
+              data.options.configure.container = dom_conf;
+            } else {
+              data.options.configure.container = undefined;
+            }
+          }
+        }
+    
+        //*************************
+        // pre-treatment for icons (unicode)
+        //*************************
+        if(data.options.groups){
+          for (var gr in data.options.groups){
+            if(data.options.groups[gr].icon){
+              if(data.options.groups[gr].icon.code){
+                data.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + data.options.groups[gr].icon.code + '"');
+              }
+              if(data.options.groups[gr].icon.face){
+                if(data.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                  data.options.groups[gr].icon.weight = "bold"
+                }
+              }
+              if(data.options.groups[gr].icon.color){
+                data.options.groups[gr].color = data.options.groups[gr].icon.color;
+              }
+            }
+          }
+        }
+        
+        if(data.options.nodes){
+          if(data.options.nodes.icon){
+            if(data.options.nodes.icon.code){
+              data.options.nodes.icon.code = JSON.parse( '"'+'\\u' + data.options.nodes.icon.code + '"');
+            }
+            if(data.options.nodes.icon.face){
+              if(data.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+                  data.options.nodes.icon.weight = "bold"
+              }
+            }
+            if(data.options.nodes.icon.color){
+              data.options.nodes.color = data.options.nodes.icon.color;
+            }
+          }
+        }
+
+        
+        update(options, data.options);
+        network.setOptions(options);
+      }
+  });
+  
+  // setData the network
+  Shiny.addCustomMessageHandler('visShinySetData', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var newnodes = new vis.DataSet();
+        var newedges = new vis.DataSet();
+		
+        newnodes.add(visNetworkdataframeToD3(data.nodes, "nodes"));
+        newedges.add(visNetworkdataframeToD3(data.edges, "edges"));
+        var newdata = {
+          nodes: newnodes,
+          edges: newedges
+        };
+        network.setData(newdata);
+      }
+  });
+  
+  // fit to a specific node
+  Shiny.addCustomMessageHandler('visShinyFit', function(data){
+    // get container id
+    var el = document.getElementById("graph"+data.id);
+    if(el){
+        var network = el.chart;
+        network.fit(data.options);
+      }
+  });
+  
+  // focus on a node in the network
+  Shiny.addCustomMessageHandler('visShinyFocus', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.focus(data.focusId, data.options);
+      }
+  });
+  
+  // stabilize the network
+  Shiny.addCustomMessageHandler('visShinyStabilize', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stabilize(data.options);
+      }
+  });
+
+  // startSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStartSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.startSimulation();
+      }
+  });
+  
+  // stopSimulation on network
+  Shiny.addCustomMessageHandler('visShinyStopSimulation', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.stopSimulation();
+      }
+  });
+  
+  // get positions of the network
+  Shiny.addCustomMessageHandler('visShinyGetPositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        if(data.nodes !== undefined){
+          pos = network.getPositions(data.nodes);
+        }else{
+          pos = network.getPositions();
+        }
+		// return positions in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get edges data
+  Shiny.addCustomMessageHandler('visShinyGetEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.edges.get({returnType:"Object"}));
+      }
+  });
+  
+  // get nodes data
+  Shiny.addCustomMessageHandler('visShinyGetNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        if(data.addCoordinates){
+          el.chart.storePositions();
+        }
+        // return data in shiny
+        Shiny.onInputChange(data.input, el.nodes.get({returnType:"Object"}));
+      }
+  });
+  
+  // get selected edges
+  Shiny.addCustomMessageHandler('visShinyGetSelectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedEdges();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selected nodes
+  Shiny.addCustomMessageHandler('visShinyGetSelectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getSelectedNodes();
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedEdges
+  Shiny.addCustomMessageHandler('visShinyGetConnectedEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedEdges(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getConnectedNodes
+  Shiny.addCustomMessageHandler('visShinyGetConnectedNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getConnectedNodes(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // getBoundingBox
+  Shiny.addCustomMessageHandler('visShinyGetBoundingBox', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos = network.getBoundingBox(data.nodeId);
+        // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get selection
+  Shiny.addCustomMessageHandler('visShinyGetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getSelection();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get scale
+  Shiny.addCustomMessageHandler('visShinyGetScale', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getScale();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // store positions
+  Shiny.addCustomMessageHandler('visShinyStorePositions', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        network.storePositions();
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetViewPosition', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        var pos;
+        
+        pos = network.getViewPosition();
+
+		    // return  in shiny
+        Shiny.onInputChange(data.input, pos);
+      }
+  });
+  
+  // get view position
+  Shiny.addCustomMessageHandler('visShinyGetOptionsFromConfigurator', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+		    // return  in shiny
+        Shiny.onInputChange(data.input, network.getOptionsFromConfigurator());
+      }
+  });
+  
+  // Redraw the network
+  Shiny.addCustomMessageHandler('visShinyRedraw', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        el.chart.redraw();
+      }
+  });
+  
+  // select nodes
+  Shiny.addCustomMessageHandler('visShinySelectNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectNodes(data.selid, data.highlightEdges);
+          if(data.clickEvent){
+            el.myclick({nodes : data.selid});
+          }
+        }else{
+          if(data.clickEvent){
+            el.myclick({nodes : []});
+          }
+        }
+      }
+  });
+  
+  // select edges
+  Shiny.addCustomMessageHandler('visShinySelectEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selid !== null){
+          network.selectEdges(data.selid);
+        }
+      }
+  });
+  
+  // set selection
+  Shiny.addCustomMessageHandler('visShinySetSelection', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(el){
+        var network = el.chart;
+        if(data.selection.nodes !== null || data.selection.edges !== null){
+          network.setSelection(data.selection, data.options);
+        }
+        if(data.clickEvent){
+          if(data.selection.nodes !== null){
+            el.myclick({nodes : data.selection.nodes});
+          } else {
+           el.myclick({nodes : []}); 
+          }
+        }
+      }
+  });
+  
+  function updateVisOptions(data){
+        // get container id
+        var graph = document.getElementById("graph"+data.id);
+        var el = document.getElementById(data.id);
+        var do_loop_by = false;
+        var option2;
+        var selectList2;
+        var selectList;
+        var reset = false;
+        
+        if(graph){
+          // reset nodes before ?
+          if(document.getElementById(el.id).highlight){
+            // need reset nodes
+            if(document.getElementById(el.id).highlightActive === true){
+              reset = true;
+            }
+          }
+          if(reset){
+            document.getElementById("nodeSelect"+data.id).value = "";
+            document.getElementById("nodeSelect"+data.id).onchange();
+          }
+          
+          // collapse init
+          if(data.options.collapse !== undefined){
+            el.collapse = data.options.collapse.enabled;
+            el.collapseFit = data.options.collapse.fit;
+            el.collapseResetHighlight = data.options.collapse.resetHighlight;
+            el.collapseKeepCoord = data.options.collapse.keepCoord;
+            el.collapseLabelSuffix = data.options.collapse.labelSuffix;
+            el.clusterOptions = data.options.collapse.clusterOptions;
+          }
+          
+          // highlight init
+          if(data.options.highlight !== undefined){
+            el.highlight = data.options.highlight.enabled;
+            el.degree = data.options.highlight.degree;
+            el.hoverNearest = data.options.highlight.hoverNearest;
+            el.highlightColor = data.options.highlight.hideColor;
+            el.highlightAlgorithm = data.options.highlight.algorithm;
+            el.highlightLabelOnly = data.options.labelOnly;
+          }
+
+          // byselection init
+          if(data.options.byselection !== undefined){
+            if(data.options.byselection.selected !== undefined){
+              document.getElementById("selectedBy"+data.id).value = data.options.byselection.selected;
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+            if(data.options.byselection.hideColor){
+              el.byselectionColor = data.options.byselection.hideColor;
+            }
+            if(data.options.byselection.highlight !== undefined){
+              el.byselectionHighlight = data.options.byselection.highlight;
+            }
+          }
+          
+          if(data.options.byselection !== undefined){
+            selectList2 = document.getElementById("selectedBy"+data.id)
+            selectList2.options.length = 0;
+            if(data.options.byselection.enabled === true){
+              option2 = document.createElement("option");
+              option2.value = "";
+              if(data.options.byselection.main === undefined){
+                option2.text = "Select by " + data.options.byselection.variable;
+              } else {
+                option2.text = data.options.byselection.main;
+              }
+              
+              selectList2.appendChild(option2);
+      
+              if(data.options.byselection.values !== undefined){
+                for (var i = 0; i < data.options.byselection.values.length; i++) {
+                  option2 = document.createElement("option");
+                  option2.value = data.options.byselection.values[i];
+                  option2.text = data.options.byselection.values[i];
+                  selectList2.appendChild(option2);
+                }
+              }else{
+                do_loop_by = true;
+              }
+
+              el.byselection_variable = data.options.byselection.variable;
+              el.byselection_multiple = data.options.byselection.multiple;
+              selectList2.style.display = 'inline';
+              if(data.options.byselection.style !== undefined){
+                selectList2.setAttribute('style', data.options.byselection.style);
+              }
+              el.byselection = true;
+            } else {
+              selectList2.style.display = 'none';
+              el.byselection = false;
+              // reset selection
+              if(el.selectActive === true){
+                document.getElementById("selectedBy"+data.id).value = "";
+                document.getElementById("selectedBy"+data.id).onchange();
+              }
+            }
+          }else{
+            // reset selection
+            if(el.selectActive === true){
+              document.getElementById("selectedBy"+data.id).value = "";
+              document.getElementById("selectedBy"+data.id).onchange();
+            }
+          }
+          
+          if(do_loop_by){
+              var allNodes = graph.nodes.get({returnType:"Object"});
+              var byselection_values = [];
+              for (var nodeId in allNodes) {
+                if(do_loop_by){
+                  var current_sel_value = allNodes[nodeId][data.options.byselection.variable];
+                  if(data.options.byselection.multiple){
+                    current_sel_value = current_sel_value.split(",").map(Function.prototype.call, String.prototype.trim);
+                  }else{
+                    current_sel_value = [current_sel_value];
+                  }
+                  for(var ind_c in current_sel_value){
+                    if(indexOf.call(byselection_values, current_sel_value[ind_c], false) === -1){
+                      option2 = document.createElement("option");
+                      option2.value = current_sel_value[ind_c];
+                      option2.text = current_sel_value[ind_c];
+                      selectList2.appendChild(option2);
+                      byselection_values.push(current_sel_value[ind_c]);
+                    }
+                  }
+                }
+              } 
+          }
+          
+          // node id selection init
+          if(data.options.idselection !== undefined){
+            selectList = document.getElementById("nodeSelect"+data.id)
+            selectList.options.length = 0;
+            if(data.options.idselection.enabled === true){
+              setNodeIdList(selectList, data.options.idselection, graph.nodes)
+              el.idselection = true;
+            } else {
+              selectList.style.display = 'none';
+              el.idselection = false;
+            }
+            if(data.options.idselection.useLabels !== undefined){
+              el.idselection_useLabels = data.options.idselection.useLabels
+            }
+          }
+          
+          if(data.options.idselection !== undefined){
+            if(data.options.idselection.enabled === true && data.options.idselection.selected !== undefined){
+              document.getElementById("nodeSelect"+data.id).value = data.options.idselection.selected;
+              document.getElementById("nodeSelect"+data.id).onchange();
+            }
+          }
+        }
+  };
+      
+  Shiny.addCustomMessageHandler('visShinyCustomOptions', updateVisOptions);
+  
+  // udpate nodes data
+  Shiny.addCustomMessageHandler('visShinyUpdateNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      
+      if(data.legend === false){
+        if(el){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          
+          // reset some parameters / data before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+
+            //reset nodes
+            resetAllEdges(el.edges, el.highlightColor, el.byselectionColor, el.chart);
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // update nodes
+          el.nodes.update(tmpnodes);
+          
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpnodes = visNetworkdataframeToD3(data.nodes, "nodes");
+          // update nodes
+          legend_network.network.body.data.nodes.update(tmpnodes);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+
+  // udpate edges data
+  Shiny.addCustomMessageHandler('visShinyUpdateEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // get edges object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.update(tmpedges);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // get & transform nodes object
+          var tmpedges = visNetworkdataframeToD3(data.edges, "edges");
+          // update edges
+          legend_network.network.body.data.edges.update(tmpedges);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove nodes
+  Shiny.addCustomMessageHandler('visShinyRemoveNodes', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      var main_el = document.getElementById(data.id);
+      if(data.legend === false){
+        if(el){
+          // reset some parameters / date before
+          if (main_el.selectActive === true | main_el.highlightActive === true) {
+            //reset nodes
+            resetAllNodes(el.nodes, true, el.options, el.chart, false);
+            
+            if (main_el.selectActive === true){
+              main_el.selectActive = false;
+              resetList('selectedBy', data.id, 'selectedBy');
+            }
+            if (main_el.highlightActive === true){
+              main_el.highlightActive = false;
+              resetList('nodeSelect', data.id, 'selected');
+            }
+          }
+          // remove nodes
+          el.nodes.remove(data.rmid);
+  
+          // update options ?
+          if(data.updateOptions){
+            var dataOptions = {};
+            dataOptions.options = {};
+          
+            var updateOpts = false;
+            if(document.getElementById("nodeSelect"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.idselection = {enabled : true, useLabels : main_el.idselection_useLabels};
+            }
+      
+            if(document.getElementById("selectedBy"+data.id).style.display === 'inline'){
+              updateOpts = true;
+              dataOptions.id  = data.id;
+              dataOptions.options.byselection = {enabled : true, variable : main_el.byselection_variable, multiple : main_el.byselection_multiple};
+            }
+          
+            if(updateOpts){
+              updateVisOptions(dataOptions);
+            }
+          }
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove nodes
+          legend_network.network.body.data.nodes.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinyRemoveEdges', function(data){
+      // get container id
+      var el = document.getElementById("graph"+data.id);
+      if(data.legend === false){
+        if(el){
+          // reset edges
+          resetAllEdges(el.edges, el.highlightColor,  el.byselectionColor, el.chart)
+          el.edges.remove(data.rmid);
+        }
+      } else if(data.legend === true){
+        var legend_network = document.getElementById("legend"+data.id);
+        if(legend_network){
+          // remove edges
+          legend_network.network.body.data.edges.remove(data.rmid);
+          // fit
+          legend_network.network.fit();
+        }
+      }
+  });
+  
+  // remove edges
+  Shiny.addCustomMessageHandler('visShinySetTitle', function(data){
+    if(data.main !== null){
+      var div_title = document.getElementById("title" + data.id);
+      if(div_title !== null){
+        if(data.main.hidden === true){
+          div_title.style.display = 'none';
+        } else {
+          if(data.main.text !== undefined){
+            if(data.main.text !== null){
+              if(data.main.text.length > 0){
+                div_title.innerHTML = data.main.text;
+              } else {
+                div_title.innerHTML = "";
+              }
+            }
+          }
+          if(data.main.style !== undefined){
+            if(data.main.style !== null){
+              if(data.main.style.length > 0){
+                div_title.setAttribute('style',  data.main.style);
+              }
+            }
+          }
+          div_title.style.display = 'block';
+        } 
+      }
+    }
+    if(data.submain !== null){
+      var div_subtitle = document.getElementById("subtitle" + data.id);
+      if(div_subtitle !== null){
+        if(data.submain.hidden === true){
+          div_subtitle.style.display = 'none';
+        } else {
+          if(data.submain.text !== undefined){
+            if(data.submain.text !== null){
+              if(data.submain.text.length > 0){
+                div_subtitle.innerHTML = data.submain.text;
+              } else {
+                div_subtitle.innerHTML = "";
+              }
+            }
+          }
+          if(data.submain.style !== undefined){
+            if(data.submain.style !== null){
+              if(data.submain.style.length > 0){
+                div_subtitle.setAttribute('style',  data.submain.style);
+              }
+            }
+          }
+          div_subtitle.style.display = 'block';
+        }
+      }
+    }
+    if(data.footer !== null){
+      var div_footer = document.getElementById("footer" + data.id);
+      if(div_footer !== null){
+        if(data.footer.hidden === true){
+          div_footer.style.display = 'none';
+        } else {
+          if(data.footer.text !== undefined){
+            if(data.footer.text !== null){
+              if(data.footer.text.length > 0){
+                div_footer.innerHTML = data.footer.text;
+              } else {
+                div_footer.innerHTML = "";
+              }
+            }
+          }
+          if(data.footer.style !== undefined){
+            if(data.footer.style !== null){
+              if(data.footer.style.length > 0){
+                div_footer.setAttribute('style',  data.footer.style);
+              }
+            }
+          }
+          div_footer.style.display = 'block';
+        } 
+      }
+    }
+  });
+
+  // updateTree
+  Shiny.addCustomMessageHandler('visShinyUpdateTree', function(data){
+      // get container id
+      var el = document.getElementById(data.id);
+      if(el){
+      if(el.tree){
+          if(data.tree.updateShape != undefined){
+            el.tree.updateShape = data.tree.updateShape
+          }
+          if(data.tree.shapeVar != undefined){
+            el.tree.shapeVar = data.tree.shapeVar
+          }
+          if(data.tree.shapeY != undefined){
+            el.tree.shapeY = data.tree.shapeY
+          }
+        }
+      }
+  });
+}
+
+//----------------------------------------------------------------
+// HTMLWidgets.widget Definition
+//--------------------------------------------------------------- 
+HTMLWidgets.widget({
+  
+  name: 'visNetwork',
+  
+  type: 'output',
+  
+  initialize: function(el, width, height) {
+    return {
+    };
+  },
+  
+  renderValue: function(el, x, instance) {
+    var data;
+    var nodes;
+    var edges;
+
+
+    // clustergin by zoom variables
+    var clusterIndex = 0;
+    var clusters = [];
+    var lastClusterZoomLevel = 0;
+    var clusterFactor;
+    var ctrlwait = 0;
+    
+    // legend control
+    var addlegend = false;
+
+    // main div el.id
+    var el_id = document.getElementById(el.id);
+    
+    // test background
+    el_id.style.background = x.background;
+    
+    // clear el.id (for shiny...)
+    el_id.innerHTML = "";  
+    
+    // shared control with proxy function (is there a better way ?)
+    el_id.highlightActive = false;
+    el_id.selectActive = false;
+    el_id.idselection = x.idselection.enabled;
+    el_id.byselection = x.byselection.enabled;
+    
+    if(x.highlight !== undefined){
+      el_id.highlight = x.highlight.enabled;
+      el_id.highlightColor = x.highlight.hideColor;
+      el_id.hoverNearest = x.highlight.hoverNearest;
+      el_id.degree = x.highlight.degree;
+      el_id.highlightAlgorithm = x.highlight.algorithm;
+      el_id.highlightLabelOnly = x.highlight.labelOnly;
+    } else {
+      el_id.highlight = false;
+      el_id.hoverNearest = false;
+      el_id.highlightColor = 'rgba(200,200,200,0.5)';
+      el_id.degree = 1;
+      el_id.highlightAlgorithm = "all";
+      el_id.highlightLabelOnly = true;
+    }
+
+    if(x.byselection.enabled){
+      el_id.byselectionColor = x.byselection.hideColor;
+      el_id.byselectionHighlight = x.byselection.highlight;
+    } else {
+      el_id.byselectionColor = 'rgba(200,200,200,0.5)';
+      el_id.byselectionHighlight = false;
+    }
+    
+    if(x.idselection.enabled){
+      el_id.idselection_useLabels = true;
+    } else {
+      el_id.idselection_useLabels = false;
+    }
+    
+    if(x.collapse !== undefined){
+      if(x.collapse.enabled){
+        el_id.collapse = true;
+        el_id.collapseFit = x.collapse.fit;
+        el_id.collapseResetHighlight = x.collapse.resetHighlight;
+        el_id.collapseKeepCoord = x.collapse.keepCoord;
+        el_id.collapseLabelSuffix = x.collapse.labelSuffix;
+        el_id.clusterOptions = x.collapse.clusterOptions;
+      }
+    } else {
+      el_id.collapse = false;
+      el_id.collapseFit = false;
+      el_id.collapseResetHighlight = false;
+      el_id.collapseKeepCoord = true;
+      el_id.collapseLabelSuffix = " (cluster)";
+      el_id.clusterOptions = undefined;
+    }
+    
+    if(x.tree !== undefined){
+      el_id.tree = x.tree;
+    }
+
+    // configure
+    if(x.options.configure !== undefined){
+      if(x.options.configure.container !== undefined){
+        var dom_conf = document.getElementById(x.options.configure.container);
+        if(dom_conf !== null){
+          x.options.configure.container = dom_conf;
+        } else {
+          x.options.configure.container = undefined;
+        }
+      }
+    }
+    
+    var changeInput = function(id, data) {
+            Shiny.onInputChange(el.id + '_' + id, data);
+    };
+          
+    //*************************
+    //title
+    //*************************
+    var div_title = document.createElement('div');
+    div_title.id = "title"+el.id;
+    div_title.setAttribute('style','font-family:Georgia, Times New Roman, Times, serif;font-weight:bold;font-size:20px;text-align:center;');
+    div_title.style.display = 'none';
+    el_id.appendChild(div_title);  
+    if(x.main !== null){
+      div_title.innerHTML = x.main.text;
+      div_title.setAttribute('style',  x.main.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+    
+    //*************************
+    //subtitle
+    //*************************
+    var div_subtitle = document.createElement('div');
+    div_subtitle.id = "subtitle"+el.id;
+    div_subtitle.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;');
+    div_subtitle.style.display = 'none';
+    el_id.appendChild(div_subtitle); 
+    if(x.submain !== null){
+      div_subtitle.innerHTML = x.submain.text;
+      div_subtitle.setAttribute('style',  x.submain.style + ";background-color: inherit;");
+      div_title.style.display = 'block';
+    }
+ 
+    //*************************
+    //init idselection
+    //*************************
+    function onIdChange(id, init) {
+      if(id === ""){
+        instance.network.selectNodes([]);
+      }else{
+        instance.network.selectNodes([id]);
+      }
+      if(el_id.highlight){
+        neighbourhoodHighlight(instance.network.getSelection().nodes, "click", el_id.highlightAlgorithm, true);
+      }else{
+        if(init){
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, id, true) > -1){
+              selectNode.value = id;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = id;
+          }
+        }
+      }
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+      if(el_id.byselection){
+        resetList('selectedBy', el.id, 'selectedBy');
+      }
+    }
+      
+    // id nodes selection : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    var idList = document.createElement("select");
+    idList.setAttribute('class', 'dropdown');
+    idList.style.display = 'none';
+    idList.id = "nodeSelect"+el.id;
+    el_id.appendChild(idList);
+      
+    idList.onchange =  function(){
+      if(instance.network){
+        onIdChange(document.getElementById("nodeSelect"+el.id).value, false);
+      }
+    };
+      
+    var hr = document.createElement("hr");
+    hr.setAttribute('style', 'height:0px; visibility:hidden; margin-bottom:-1px;');
+    el_id.appendChild(hr);  
+      
+    //*************************
+    //selectedBy
+    //*************************
+    function onByChange(value) {
+        if(instance.network){
+          selectedHighlight(value);
+        }
+        if (window.Shiny){
+          changeInput('selectedBy', value);
+        }
+        if(el_id.idselection){
+          resetList('nodeSelect', el.id, 'selected');
+        }
+    }
+    
+    // selectedBy : add a list on top left
+    // actually only with nodes + edges data (not dot and gephi)
+    //Create and append select list
+    var byList = document.createElement("select");
+    byList.setAttribute('class', 'dropdown');
+    byList.style.display = 'none';
+    byList.id = "selectedBy"+el.id;
+    el_id.appendChild(byList);
+
+    byList.onchange =  function(){
+      onByChange(document.getElementById("selectedBy"+el.id).value);
+    };
+      
+    if(el_id.byselection){
+
+      el_id.byselection_values = x.byselection.values;
+      el_id.byselection_variable = x.byselection.variable;
+      el_id.byselection_multiple = x.byselection.multiple;
+      var option2;
+      
+      //Create and append select list
+      var selectList2 = document.getElementById("selectedBy"+el.id);
+      selectList2.setAttribute('style', x.byselection.style);
+      selectList2.style.display = 'inline';
+      
+      option2 = document.createElement("option");
+      option2.value = "";
+      if(x.byselection.main === undefined){
+        option2.text = "Select by " + x.byselection.variable;
+      } else {
+        option2.text = x.byselection.main;
+      }
+
+      selectList2.appendChild(option2);
+      
+      //Create and append the options
+      for (var i2 = 0; i2 < x.byselection.values.length; i2++) {
+        option2 = document.createElement("option");
+        option2.value = x.byselection.values[i2];
+        option2.text = x.byselection.values[i2];
+        selectList2.appendChild(option2);
+      }
+      
+      if (window.Shiny){
+        changeInput('selectedBy', document.getElementById("selectedBy"+el.id).value);
+      }
+    }
+    
+    //*************************
+    // pre-treatment for icons (unicode)
+    //*************************
+    if(x.options.groups){
+      for (var gr in x.options.groups){
+        if(x.options.groups[gr].icon){
+          if(x.options.groups[gr].icon.code){
+            x.options.groups[gr].icon.code = JSON.parse( '"'+'\\u' + x.options.groups[gr].icon.code + '"');
+          }
+          if(x.options.groups[gr].icon.face){
+            if(x.options.groups[gr].icon.face === "'Font Awesome 5 Free'"){
+                x.options.groups[gr].icon.weight = "bold"
+            }
+          }
+          if(x.options.groups[gr].icon.color){
+            x.options.groups[gr].color = x.options.groups[gr].icon.color;
+          }
+        }
+      }
+    }
+    
+    if(x.options.nodes.icon){
+        if(x.options.nodes.icon.code){
+          x.options.nodes.icon.code = JSON.parse( '"'+'\\u' + x.options.nodes.icon.code + '"');
+        }
+        if(x.options.nodes.icon.face){
+          if(x.options.nodes.icon.face === "'Font Awesome 5 Free'"){
+              x.options.nodes.icon.weight = "bold"
+          }
+        }
+        if(x.options.nodes.icon.color){
+          x.options.nodes.color = x.options.nodes.icon.color;
+        }
+    }
+    
+    //*************************
+    //page structure
+    //*************************
+    
+    // divide page
+    var maindiv  = document.createElement('div');
+    maindiv.id = "maindiv"+el.id;
+    maindiv.setAttribute('style', 'height:95%;background-color: inherit;');
+    el_id.appendChild(maindiv);
+    
+    var graph = document.createElement('div');
+    graph.id = "graph"+el.id;
+    
+    if(x.legend !== undefined){
+      if((x.groups && x.legend.useGroups) || (x.legend.nodes !== undefined) || (x.legend.edges !== undefined)){
+        addlegend = true;
+      }
+    }
+    
+    //legend
+    if(addlegend){
+      var legendwidth = x.legend.width*100;
+      var legend = document.createElement('div');
+      
+      var pos = x.legend.position;
+      var pos2 = "right";
+      if(pos == "right"){
+        pos2 = "left";
+      }
+      
+      legend.id = "legend"+el.id;
+      legend.setAttribute('style', 'float:' + pos + '; width:'+legendwidth+'%;height:100%');
+      
+      //legend title
+      if(x.legend.main !== undefined){
+        var legend_title = document.createElement('div');
+        legend_title.innerHTML = x.legend.main.text;
+        legend_title.setAttribute('style',  x.legend.main.style);
+        legend.appendChild(legend_title);  
+        
+        legend.id = "legend_main"+el.id;
+        var legend_network = document.createElement('div');
+        legend_network.id = "legend"+el.id;
+        legend_network.setAttribute('style', 'height:100%');
+        legend.appendChild(legend_network); 
+      }
+      
+      document.getElementById("maindiv"+el.id).appendChild(legend);
+      graph.setAttribute('style', 'float:' + pos2 + '; width:'+(100-legendwidth)+'%;height:100%;background-color: inherit;');
+    }else{
+      graph.setAttribute('style', 'float:right; width:100%;height:100%;background-color: inherit;');
+    }
+    
+    document.getElementById("maindiv"+el.id).appendChild(graph);
+    
+    //*************************
+    //legend definition
+    //*************************
+    if(addlegend){
+      
+      var legendnodes = new vis.DataSet();
+      var legendedges = null;
+      var datalegend;
+      var tmpnodes;
+      
+      // set some options
+      var optionslegend = {
+        interaction:{
+          dragNodes: false,
+          dragView: false,
+          selectable: false,
+          zoomView: x.legend.zoom
+        },
+        physics:{
+          stabilization: false
+        }
+      };
+      
+      function range(start, length, step, rep){
+        var a=[], b=start;
+        while(a.length < length){
+          for (var i = 0; i < rep; i++){
+            a.push(b);
+            if(a.length === length){
+              break;
+            }
+          }
+          b+=step;
+        }
+        return a;
+      };
+      
+      var mynetwork = document.getElementById('legend'+el.id);
+      var lx = mynetwork.clientWidth / 2 + 50;
+      var ly = mynetwork.clientHeight / 2 + 50;
+      var edge_ly = ly;
+      var ncol = x.legend.ncol;
+      var step_x = x.legend.stepX;
+      var step_y = x.legend.stepY;
+      var tmp_ly;
+      var tmp_lx = lx;
+      var tmp_lx2;
+      var all_tmp_y = [];
+      if(tmp_lx === 0){
+        tmp_lx = 1
+      }
+      
+      // construct nodes data if needed
+      if(x.legend.nodes !== undefined){
+        if(x.legend.nodesToDataframe){ // data in data.frame
+          tmpnodes = visNetworkdataframeToD3(x.legend.nodes, "nodes")
+        } else { // data in list
+          tmpnodes = x.legend.nodes;
+        }
+        // only one element   
+        if(tmpnodes.length === undefined){
+          tmpnodes = new Array(tmpnodes);
+        }
+      }
+      
+      // array of y position 
+      if(x.groups && x.legend.useGroups && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, x.groups.length + tmpnodes.length, step_y, ncol);
+      } else if(x.groups && x.legend.useGroups && x.legend.nodes === undefined){
+        all_tmp_y = range(ly, x.groups.length, step_y, ncol);
+      } else if(x.legend.useGroups === false && x.legend.nodes !== undefined){
+        all_tmp_y = range(ly, tmpnodes.length, step_y, ncol);
+      }
+      
+      // want to view groups in legend
+      if(x.groups && x.legend.useGroups){
+        // create data
+        for (var g1 = 0; g1 < x.groups.length; g1++){
+          
+          if(g1 === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + g1%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[g1];
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          legendnodes.add({id: null, x : tmp_lx, y : tmp_ly, label: x.groups[g1], group: x.groups[g1], value: 1, mass:1});
+          edge_ly = tmp_ly;
+        }
+        // control icon size
+        if(x.options.groups){
+          optionslegend.groups = clone(x.options.groups);
+          for (var grp in optionslegend.groups) {
+            if(optionslegend.groups[grp].shape === "icon"){
+              optionslegend.groups[grp].icon.size = 50;
+            }
+          }
+        }
+      }
+      // want to add custom nodes
+      if(x.legend.nodes !== undefined){
+        
+        // control icon
+        for (var nd in tmpnodes){
+          if(tmpnodes[nd].icon  && !x.legend.nodesToDataframe){
+            tmpnodes[nd].icon.code = JSON.parse( '"'+'\\u' + tmpnodes[nd].icon.code + '"');
+          }
+          if(tmpnodes[nd].icon  && tmpnodes[nd].icon.face){
+            if(tmpnodes[nd].icon.face === "'Font Awesome 5 Free'"){
+              tmpnodes[nd].icon.weight = "bold"
+            }
+          }
+        }
+        // group control for y
+        var add_gr_y = 0;
+        if(x.groups && x.legend.useGroups){
+          add_gr_y = x.groups.length;
+        }
+        // set coordinates
+        for (var g = 0; g < tmpnodes.length; g++){
+          if((g+legendnodes.length) === 0){
+            tmp_lx = lx;
+          } else {
+            tmp_lx = lx + (g+legendnodes.length)%ncol * step_x;
+          }
+          
+          tmp_ly = all_tmp_y[add_gr_y + g];
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          tmpnodes[g].x = tmp_lx;
+          tmpnodes[g].y = tmp_ly;
+          
+          if(tmpnodes[g].value === undefined && tmpnodes[g].size === undefined){
+            tmpnodes[g].value = 1;
+          }
+          /*if(tmpnodes[g].id !== undefined){
+            tmpnodes[g].id = null;
+          }*/
+          tmpnodes[g].mass = 1;
+          edge_ly = tmp_ly;
+        }
+        legendnodes.add(tmpnodes);
+      }
+      // want to add custom edges
+      if(x.legend.edges !== undefined){
+        if(x.legend.edgesToDataframe){ // data in data.frame
+          legendedges = visNetworkdataframeToD3(x.legend.edges, "edges")
+        } else {  // data in list
+          legendedges = x.legend.edges;
+        }
+        // only one element 
+        if(legendedges.length === undefined){
+          legendedges = new Array(legendedges);
+        }
+
+        // set coordinates and options
+        for (var edg = 0; edg < (legendedges.length); edg++){
+          
+          var tmp_int = Math.floor(Math.random() * 1001);
+          legendedges[edg].from = edg + "tmp_leg_edges_" + tmp_int + "_1";
+          legendedges[edg].to = edg + "tmp_leg_edges_" + tmp_int + "_2";
+          legendedges[edg].physics = false;
+          legendedges[edg].smooth = false;
+          legendedges[edg].value = undefined;
+
+          if(legendedges[edg].arrows === undefined){
+            legendedges[edg].arrows = 'to';
+          }
+          
+          if(legendedges[edg].width === undefined){
+            legendedges[edg].width = 1;
+          }
+
+          tmp_ly = edge_ly + (edg+1)*step_y;
+          if(tmp_ly === 0){
+            tmp_ly = 1
+          }
+          
+          if(ncol === 1){
+            tmp_lx = lx - mynetwork.clientWidth/3;
+            tmp_lx2 = lx + mynetwork.clientWidth/3;
+          } else {
+            tmp_lx = lx;
+            tmp_lx2 = lx + (ncol-1) * step_x;
+          }
+          
+          if(tmp_lx === 0){
+            tmp_lx = 1
+          }
+          
+          if(tmp_lx2 === 0){
+            tmp_lx2 = 1
+          }
+          
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_1", x : tmp_lx, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+          legendnodes.add({id: edg + "tmp_leg_edges_" + tmp_int + "_2", x : tmp_lx2, y : tmp_ly, size : 0.0001, hidden : false, shape : "square", mass:1});
+        }
+      }
+      
+      // render legend network
+      datalegend = {
+        nodes: legendnodes, 
+        edges: legendedges       
+      };
+
+      
+      instance.legend = new vis.Network(document.getElementById("legend"+el.id), datalegend, optionslegend);
+      //link network for update for re-use and update
+      document.getElementById("legend"+el.id).network = instance.legend;
+    }
+    
+    //*************************
+    // Main Network rendering
+    //*************************
+    if(x.nodes){
+      
+      // network
+      nodes = new vis.DataSet();
+      edges = new vis.DataSet();
+      
+      var tmpnodes;
+      if(x.nodesToDataframe){ // data in data.frame
+        tmpnodes = visNetworkdataframeToD3(x.nodes, "nodes")
+      } else { // data in list
+        tmpnodes = x.nodes;
+      }
+      // only one element   
+      if(tmpnodes.length === undefined){
+        tmpnodes = new Array(tmpnodes);
+      }
+        
+      // update coordinates if igraph
+      if(x.igraphlayout !== undefined){
+        // to improved
+        var zoomLevel = -232.622349 / (tmpnodes.length + 91.165919)  +2.516861;
+        var igclientWidth = document.getElementById("graph"+el.id).clientWidth;
+        var scalex = 100;
+        var scaley = 100;
+        
+        // current div visibled
+        if(igclientWidth !== 0){
+          var factor = igclientWidth / 1890;
+          zoomLevel = zoomLevel/factor;
+          var scalex = (igclientWidth / 2) * zoomLevel;
+          var scaley = scalex;
+          if(x.igraphlayout.type !== "square"){
+            scaley = (document.getElementById("graph"+el.id).clientHeight / 2) * zoomLevel;
+          }
+        } else {
+          // current div not visibled....
+          igclientWidth = parseInt(el_id.style.width);
+          if(igclientWidth !== 0){
+            var factor = igclientWidth / 1890;
+            zoomLevel = zoomLevel/factor;
+            var scalex = (igclientWidth / 2) * zoomLevel;
+            var scaley = scalex;
+            if(x.igraphlayout.type !== "square"){
+              scaley = (parseInt(el_id.style.height) / 2) * zoomLevel;
+            }
+          }
+        }
+        
+        for (var nd in tmpnodes) {
+          tmpnodes[nd].x = tmpnodes[nd].x * scalex;
+          tmpnodes[nd].y = tmpnodes[nd].y * scaley;
+        }
+      }
+      
+      nodes.add(tmpnodes);
+      
+      var tmpedges;
+      if(x.edgesToDataframe){ // data in data.frame
+        tmpedges = visNetworkdataframeToD3(x.edges, "edges")
+      } else { // data in list
+        tmpedges = x.edges;
+      }
+      // only one element
+      if(tmpedges !== null){
+        if(tmpedges.length === undefined){
+          tmpedges = new Array(tmpedges);
+        }
+        edges.add(tmpedges);  
+      }
+      
+      // reset tmpnodes
+      tmpnodes = null;
+      
+      data = {
+        nodes: nodes,
+        edges: edges
+      };
+      
+      //save data for re-use and update
+      document.getElementById("graph"+el.id).nodes = nodes;
+      document.getElementById("graph"+el.id).edges = edges;
+
+    }else if(x.dot){
+      data = {
+        dot: x.dot
+      };
+    }else if(x.gephi){
+      data = {
+        gephi: x.gephi
+      };
+    } 
+    
+    var options = x.options;
+
+    //*************************
+    //manipulation
+    //*************************
+    if(x.options.manipulation.enabled){
+
+      var style = document.createElement('style');
+      style.type = 'text/css';
+      style.appendChild(document.createTextNode(x.opts_manipulation.datacss));
+      document.getElementsByTagName("head")[0].appendChild(style);
+
+      var div_addnode = document.createElement('div');
+      div_addnode.id = 'addnode-popUp';
+      div_addnode.classList.add('network-popUp');
+      div_addnode.innerHTML = x.opts_manipulation.tab_add_node;
+      el_id.appendChild(div_addnode);
+
+      var div_editnode = document.createElement('div');
+      div_editnode.id = 'editnode-popUp';
+      div_editnode.classList.add('network-popUp');
+      div_editnode.innerHTML = x.opts_manipulation.tab_edit_node;
+      el_id.appendChild(div_editnode);
+      
+      var div_editedge = document.createElement('div');
+      div_editedge.id = 'editedge-popUp';
+      div_editedge.classList.add('network-popUp');
+      div_editedge.innerHTML = x.opts_manipulation.tab_edit_edge;
+      el_id.appendChild(div_editedge);
+      
+      if(x.options.manipulation.addNode === undefined){
+        options.manipulation.addNode = function(data, callback) {
+          document.getElementById('addnode-operation').innerHTML = "Add Node";
+          for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+            document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+          }
+          document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+          document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+          document.getElementById('addnode-popUp').style.display = 'block';
+        };
+      } else if(typeof(x.options.manipulation.addNode) === typeof(true)){
+        if(x.options.manipulation.addNode){
+          options.manipulation.addNode = function(data, callback) {
+            document.getElementById('addnode-operation').innerHTML = "Add Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.addNodeCols.length; nodecol++){
+              document.getElementById('addnode-' + x.opts_manipulation.addNodeCols[nodecol]).value = data[x.opts_manipulation.addNodeCols[nodecol]];
+            }
+            document.getElementById('addnode-saveButton').onclick = saveNode.bind(this, data, callback, "addNode");
+            document.getElementById('addnode-cancelButton').onclick = clearPopUp.bind();
+            document.getElementById('addnode-popUp').style.display = 'block';
+          };
+        } else {
+          options.manipulation.addNode = false;
+        }
+      } else {
+        options.manipulation.addNode = x.options.manipulation.addNode;
+      }
+
+      if(x.options.manipulation.editNode === undefined){
+        options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+          };
+      } else if(typeof(x.options.manipulation.editNode) === typeof(true)){
+        if(x.options.manipulation.editNode){
+          options.manipulation.editNode = function(data, callback) {
+            var node_data = nodes.get(data.id);
+            document.getElementById('editnode-operation').innerHTML = "Edit Node";
+            for (var nodecol = 0; nodecol < x.opts_manipulation.editNodeCols.length; nodecol++){
+              document.getElementById('editnode-' + x.opts_manipulation.editNodeCols[nodecol]).value = node_data[x.opts_manipulation.editNodeCols[nodecol]];
+            }
+            document.getElementById('editnode-saveButton').onclick = saveNode.bind(this, data, callback, "editNode");
+            document.getElementById('editnode-cancelButton').onclick = cancelEdit.bind(this,callback);
+            document.getElementById('editnode-popUp').style.display = 'block';
+            };
+        } else {
+          options.manipulation.editNode = false;
+        }
+      } else {
+        options.manipulation.editNode = x.options.manipulation.editNode;
+      }
+  
+      if(x.options.manipulation.deleteNode === undefined){
+        options.manipulation.deleteNode = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteNode) === typeof(true)){
+        if(x.options.manipulation.deleteNode){
+          options.manipulation.deleteNode = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.nodes.length + " node(s) and " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteNode = false;
+        }
+      } else {
+        options.manipulation.deleteNode = x.options.manipulation.deleteNode;
+      }
+
+      if(x.options.manipulation.deleteEdge === undefined){
+        options.manipulation.deleteEdge = function(data, callback) {
+            var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+            if (r === true) {
+              deleteSubGraph(data, callback);
+            } else { clearPopUp(); callback(null); }
+        };
+      } else if(typeof(x.options.manipulation.deleteEdge) === typeof(true)){
+        if(x.options.manipulation.deleteEdge){
+          options.manipulation.deleteEdge = function(data, callback) {
+              var r = confirm("Do you want to delete " + data.edges.length + " edges ?");
+              if (r === true) {
+                deleteSubGraph(data, callback);
+              } else { clearPopUp(); callback(null); }
+          };
+        } else {
+          options.manipulation.deleteEdge = false;
+        }
+      } else {
+        options.manipulation.deleteEdge = x.options.manipulation.deleteEdge;
+      }
+
+      if(x.options.manipulation.addEdge === undefined){
+        options.manipulation.addEdge = function(data, callback) {
+          if (data.from == data.to) {
+            var r = confirm("Do you want to connect the node to itself?");
+            if (r === true) {
+              saveEdge(data, callback, "addEdge");
+            }
+          }
+          else {
+            saveEdge(data, callback, "addEdge");
+          }
+        };
+      } else if(typeof(x.options.manipulation.addEdge) === typeof(true)){
+        if(x.options.manipulation.addEdge){
+          options.manipulation.addEdge = function(data, callback) {
+            if (data.from == data.to) {
+              var r = confirm("Do you want to connect the node to itself?");
+              if (r === true) {
+                saveEdge(data, callback, "addEdge");
+              }
+            }
+            else {
+              saveEdge(data, callback, "addEdge");
+            }
+          };
+        } else {
+          options.manipulation.addEdge = false;
+        }
+      } else {
+        options.manipulation.addEdge = x.options.manipulation.addEdge;
+      }
+
+      if(x.options.manipulation.editEdge === undefined){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+      } else if(typeof(x.options.manipulation.editEdge) === typeof(true)){
+        if(x.options.manipulation.editEdge){
+          if(x.opts_manipulation.tab_edit_edge){
+            options.manipulation.editEdge = {editWithoutDrag : function(data, callback) {
+              var edge_data = edges.get(data.id);
+              document.getElementById('editedge-operation').innerHTML = "Edit Edge";
+              for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+                document.getElementById('editedge-' + x.opts_manipulation.editEdgeCols[edgecol]).value = edge_data[x.opts_manipulation.editEdgeCols[edgecol]];
+              }
+              document.getElementById('editedge-saveButton').onclick = saveEdge.bind(this, data, callback, "editEdgeCols");
+              document.getElementById('editedge-cancelButton').onclick = cancelEdit.bind(this,callback);
+              document.getElementById('editedge-popUp').style.display = 'block';
+            }
+            }
+          } else {
+            options.manipulation.editEdge = function(data, callback) {
+              if (data.from == data.to) {
+                var r = confirm("Do you want to connect the node to itself?");
+                if (r === true) {
+                  saveEdge(data, callback, "editEdge");
+                }
+              }
+              else {
+                saveEdge(data, callback, "editEdge");
+              }
+            };
+          }
+        } else {
+          options.manipulation.editEdge = false;
+        }
+      } else {
+        options.manipulation.editEdge = x.options.manipulation.editEdge;
+      }
+    }
+    
+    // create network
+    instance.network = new vis.Network(document.getElementById("graph"+el.id), data, options);
+    if (window.Shiny){
+      Shiny.onInputChange(el.id + '_initialized', true);
+    }
+    
+    //*************************
+    //add values to idselection
+    //*************************
+    
+    if(el_id.idselection){  
+      var selectList = document.getElementById("nodeSelect"+el.id)
+      setNodeIdList(selectList, x.idselection, nodes)
+      
+      if (window.Shiny){
+        changeInput('selected', document.getElementById("nodeSelect"+el.id).value);
+      }
+    }
+      
+    //console.info(instance.network)  
+    //save data for re-use and update
+    document.getElementById("graph"+el.id).chart = instance.network;
+    document.getElementById("graph"+el.id).options = options;
+    
+    /////////
+    // popup
+    /////////
+    
+    // Temporary variables to hold mouse x-y pos.s
+    var tempX = 0
+    var tempY = 0
+
+    // Main function to retrieve mouse x-y pos.s
+    function getMouseXY(e) {
+      tempX = e.clientX
+      tempY = e.clientY
+      // catch possible negative values in NS
+      if (tempX < 0){tempX = 0}
+      if (tempY < 0){tempY = 0}
+    }
+
+    document.addEventListener('mousemove', getMouseXY);
+
+   //this.body.emitter.emit("showPopup",{id:this.popupObj.id,x:t.x+3,y:t.y-5}))
+
+    // popup for title
+    var popupState = false;
+    var popupTimeout = null;
+    var vispopup = document.createElement("div");
+   
+    // disable vis.js tooltip 
+    var style = document.createElement('style');
+    style.type = 'text/css';
+    style.innerHTML = 'div.vis-tooltip {display : none}';
+    document.getElementsByTagName('head')[0].appendChild(style);
+
+    var popupStyle = 'position: fixed;visibility:hidden;padding: 5px;font-family: verdana;font-size:14px;font-color:#000000;background-color: #f5f4ed;-moz-border-radius: 3px;-webkit-border-radius: 3px;border-radius: 3px;border: 1px solid #808074;box-shadow: 3px 3px 10px rgba(0, 0, 0, 0.2);max-width:400px;word-break: break-all'
+    
+    if(x.tooltipStyle !== undefined){
+      popupStyle = x.tooltipStyle
+    }
+    var popupStay = 300;
+    if(x.tooltipStay !== undefined){
+      popupStay = x.tooltipStay
+    }
+    vispopup.setAttribute('style', popupStyle)
+    
+    document.getElementById("graph"+el.id).appendChild(vispopup);
+    
+    // add some event listeners to avoid it disappearing when the mouse if over it.
+    vispopup.addEventListener('mouseover',function () {
+      if (popupTimeout !== null) {
+        clearTimeout(popupTimeout);
+        popupTimeout = null;
+      }
+    });
+  
+    // set the timeout when the mouse leaves it.
+    vispopup.addEventListener('mouseout',function () {
+      if (popupTimeout === null) {
+        myHidePopup(100);
+      }
+    });
+    
+    // use the popup event to show
+    instance.network.on("showPopup", function(params) {
+      popupState = true;  
+      myShowPopup(params);
+    })
+  
+    // use the hide event to hide it
+    instance.network.on("hidePopup", function(params) {
+      // avoid double firing of this event, bug in 4.2.0
+      if (popupState === true) {
+        popupState = false;
+        myHidePopup(popupStay);
+      }
+    })
+  
+    // hiding the popup through css and a timeout
+    function myHidePopup(delay) {
+      popupTimeout = setTimeout(function() {vispopup.style.visibility = 'hidden';}, delay);
+    }
+  
+    // showing the popup
+    function myShowPopup(id) {
+      // get the data from the vis.DataSet
+      var nodeData = nodes.get([id]);
+      var edgeData = edges.get([id]);
+      
+      // a node ?
+      if(nodeData[0] !== null && nodeData[0] !== undefined){
+        vispopup.innerHTML = nodeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+        
+      } else if(edgeData[0] !== null && edgeData[0] !== undefined){
+        // so it's perhaps a edge ?
+        vispopup.innerHTML = edgeData[0].title;
+        // show and place the tooltip.
+        vispopup.style.visibility = 'visible';
+        vispopup.style.top = tempY - 20 +  "px";
+        vispopup.style.left = tempX + 5 + "px";
+      } else {
+        // or a cluster ?
+        var node_cluster = instance.network.body.nodes[id]
+        if(node_cluster !== undefined){
+          vispopup.innerHTML = node_cluster.options.title;
+          // show and place the tooltip.
+          vispopup.style.visibility = 'visible';
+          vispopup.style.top = tempY - 20 +  "px";
+          vispopup.style.left = tempX + 5 + "px";
+        }
+      }
+      
+      // for sparkline. Eval script...
+      var any_script= vispopup.getElementsByTagName('script')
+      for (var n = 0; n < any_script.length; n++){
+        if(any_script[n].getAttribute("type") === "text/javascript"){
+           eval(any_script[n].innerHTML);
+        }
+      }
+    }
+  
+    //*************************
+    // Events
+    //*************************
+    if(x.events !== undefined){
+      for (var key in x.events) {
+          instance.network.on(key, x.events[key]);
+      }
+    }
+
+    if(x.OnceEvents !== undefined){
+      for (var key in x.OnceEvents) {
+          instance.network.once(key, x.OnceEvents[key]);
+      }
+    }
+    
+    if(x.ResetEvents !== undefined){
+      for (var key in x.ResetEvents) {
+          instance.network.off(key);
+      }
+    }
+    //*************************
+    // Selected Highlight
+    //*************************
+
+    function selectedHighlight(value) {
+      // get current nodes
+      var allNodes = nodes.get({returnType:"Object"});
+       
+      // first resetEdges
+      resetAllEdges(edges, el_id.byselectionColor, el_id.highlightColor, instance.network);
+      var connectedNodes = [];  
+      
+      // get variable
+      var sel = el_id.byselection_variable;
+      // need to make an update?
+      var update = !(el_id.selectActive === false && value === "");
+
+      if (value !== "") {
+        var updateArray = [];
+        el_id.selectActive = true;
+        
+        // mark all nodes as hard to read.
+        for (var nodeId in allNodes) {
+          var value_in = false;
+          // unique selection
+          if(el_id.byselection_multiple === false){
+            if(sel == "label"){
+              value_in = ((allNodes[nodeId]["label"] + "") === value) || ((allNodes[nodeId]["hiddenLabel"] + "") === value);
+            }else if(sel == "color"){
+              value_in = ((allNodes[nodeId]["color"] + "") === value) || ((allNodes[nodeId]["hiddenColor"] + "") === value);
+            }else {
+              value_in = (allNodes[nodeId][sel] + "") === value;
+            }
+          }else{ // multiple selection
+            if(sel == "label"){
+              var current_value = allNodes[nodeId]["label"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenLabel"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else if(sel == "color"){
+              var current_value = allNodes[nodeId]["color"] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              var current_value2 = allNodes[nodeId]["hiddenColor"] + "";
+              var value_split2 = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = (value_split.indexOf(value) !== -1) || (value_split2.indexOf(value) !== -1);
+            }else {
+              var current_value = allNodes[nodeId][sel] + "";
+              var value_split = current_value.split(",").map(Function.prototype.call, String.prototype.trim);
+              value_in = value_split.indexOf(value) !== -1;
+            }
+          }
+          if(value_in === false){ // not in selection, so as hard to read
+            nodeAsHardToRead(allNodes[nodeId], options, el_id.byselectionColor, el_id.highlightColor, instance.network, "node");
+          } else { // in selection, so reset if needed
+            connectedNodes = connectedNodes.concat(allNodes[nodeId].id);
+            resetOneNode(allNodes[nodeId], options, instance.network);
+          }
+          allNodes[nodeId].x = undefined;
+          allNodes[nodeId].y = undefined;
+          // update data
+          if (allNodes.hasOwnProperty(nodeId) && update) {
+            updateArray.push(allNodes[nodeId]);
+          }
+        }
+        if(update){
+          // set some edges as hard to read
+          var edgesHardToRead = edges.get({
+            fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+            filter: function (item) {
+              return (indexOf.call(connectedNodes, item.from, true) === -1) ;
+            },
+            returnType :'Array'
+          });
+
+          // all in degree nodes get their own color and their label back
+          for (i = 0; i < edgesHardToRead.length; i++) {
+            edgeAsHardToRead(edgesHardToRead[i], el_id.byselectionColor, el_id.highlightColor, instance.network, type = "edge")
+          }
+          edges.update(edgesHardToRead);
+            
+          nodes.update(updateArray);
+          
+          // select for highlight
+          if(el_id.highlight && x.nodes && el_id.byselectionHighlight){
+              neighbourhoodHighlight(connectedNodes, "click", el_id.highlightAlgorithm, false);
+              instance.network.selectNodes(connectedNodes)
+          }
+        }
+      }
+      else if (el_id.selectActive === true) {
+        //reset nodes
+        resetAllNodes(nodes, update, options, instance.network, false)
+        el_id.selectActive = false
+      }
+    } 
+  
+    //*************************
+    //Highlight
+    //*************************
+    var is_hovered = false;
+    var is_clicked = false;
+    
+    function neighbourhoodHighlight(params, action_type, algorithm, reset_selectedBy) {
+
+      var nodes_in_clusters = instance.network.body.modules.clustering.clusteredNodes;
+      var have_cluster_nodes = false;
+      if(Object.keys(nodes_in_clusters).length > 0){
+        have_cluster_nodes = true;
+        nodes_in_clusters = Object.keys(nodes_in_clusters);
+        edges_in_clusters = Object.keys(instance.network.body.modules.clustering.clusteredEdges);
+      } else {
+        nodes_in_clusters = [];
+        edges_in_clusters = [];
+      }
+      
+      var selectNode;
+      // get nodes data
+      var allNodes = nodes.get({returnType:"Object"});
+
+      // cluster
+      var array_cluster_id;
+      
+      // update 
+      var update = !(el_id.highlightActive === false && params.length === 0) | (el_id.selectActive === true && params.length === 0);
+
+      if(!(action_type == "hover" && is_clicked)){
+        
+        // first resetEdges
+        resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+
+        if (params.length > 0) {
+          var is_cluster = instance.network.isCluster(params[0]);
+          var selectedNode;
+          
+          if(is_cluster){
+            selectedNode = instance.network.getNodesInCluster(params[0]);
+          } else {
+            selectedNode = params;
+          }
+
+          var updateArray = [];
+          if(el_id.idselection){
+            selectNode = document.getElementById('nodeSelect'+el.id);
+            if(is_cluster === false){
+              if(x.idselection.values !== undefined){
+                if(indexOf.call(x.idselection.values, selectedNode[0], true) > -1){
+                  selectNode.value = selectedNode[0];
+                }else{
+                  selectNode.value = "";
+                }
+              }else{
+                selectNode.value = selectedNode[0];
+              }
+              if (window.Shiny){
+                changeInput('selected', selectNode.value);
+              }
+            }
+          }
+          
+          el_id.highlightActive = true;
+          var i,j;
+          var degrees = el_id.degree;
+          
+          // mark all nodes as hard to read.
+          for (var nodeId in instance.network.body.nodes) {
+            if(instance.network.isCluster(nodeId)){
+              nodeAsHardToRead(instance.network.body.nodes[nodeId], options, el_id.highlightColor, el_id.byselectionColor, instance.network, "cluster");
+            }else {
+              var tmp_node = allNodes[nodeId];
+              if(tmp_node !== undefined){
+                nodeAsHardToRead(tmp_node, options, el_id.highlightColor, el_id.byselectionColor, instance.network, "node");
+                tmp_node.x = undefined;
+                tmp_node.y = undefined;
+              }
+            }
+          }
+ 
+          if(algorithm === "all"){
+            var connectedNodes;
+            if(degrees > 0){
+              connectedNodes = [];
+              for (j = 0; j < selectedNode.length; j++) {
+                connectedNodes = connectedNodes.concat(instance.network.getConnectedNodes(selectedNode[j], true));
+              }
+              connectedNodes = uniqueArray(connectedNodes, true, instance.network);
+            }else{
+              connectedNodes = selectedNode;
+            }
+            
+            var allConnectedNodes = [];
+            // get the nodes to color
+            if(degrees >= 2){
+              for (i = 2; i <= degrees; i++) {
+                var previous_connectedNodes = connectedNodes;
+                var currentlength = connectedNodes.length;
+                for (j = 0; j < currentlength; j++) {
+                  connectedNodes = uniqueArray(connectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j])), true, instance.network);
+                }
+                if (connectedNodes.length === previous_connectedNodes.length) { break; }
+              }
+            }
+            // nodes to just label
+            for (j = 0; j < connectedNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(instance.network.getConnectedNodes(connectedNodes[j]));
+            }
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network);
+
+            if(el_id.highlightLabelOnly === true){
+              // all higher degree nodes get a different color and their label back
+              array_cluster_id = [];
+              for (i = 0; i < allConnectedNodes.length; i++) {
+                if (allNodes[allConnectedNodes[i]].hiddenLabel !== undefined) {
+                  allNodes[allConnectedNodes[i]].label = allNodes[allConnectedNodes[i]].hiddenLabel;
+                  allNodes[allConnectedNodes[i]].hiddenLabel = undefined;
+                  if(have_cluster_nodes){
+                    if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+  
+                      array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                    }
+                  }
+                }
+              }
+  
+              if(array_cluster_id.length > 0){
+                array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+                for (i = 0; i < array_cluster_id.length; i++) {
+                  instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+                }
+              }
+            }
+
+            // all in degree nodes get their own color and their label back + main nodes
+            connectedNodes = connectedNodes.concat(selectedNode);
+            
+            if (window.Shiny){
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(connectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', allConnectedNodes.filter(function(x){ return !connectedNodes.includes(x)}));
+              }
+            }  
+   
+            array_cluster_id = [];
+            for (i = 0; i < connectedNodes.length; i++) {
+              resetOneNode(allNodes[connectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, connectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(connectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(connectedNodes, item.from, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            var tmp_cluster_id;
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster")
+              }
+            }
+            edges.update(edgesHardToRead);
+          } else if(algorithm === "hierarchical"){
+            
+            var degree_from = degrees.from;
+            var degree_to = degrees.to;
+            degrees = Math.max(degree_from, degree_to);
+            
+            var allConnectedNodes = [];
+            var currentConnectedFromNodes = [];
+            var currentConnectedToNodes = [];
+            var connectedFromNodes = [];
+            var connectedToNodes = [];
+            
+            if(degree_from > 0){
+              connectedFromNodes = edges.get({
+                fields: ['from'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.to, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+
+            if(degree_to > 0){
+              connectedToNodes = edges.get({
+                fields: ['to'],
+                filter: function (item) {
+                  return ((indexOf.call(selectedNode, item.from, true) !== -1)) ;
+                },
+                returnType :'Array'
+              });
+            }
+            for (j = 0; j < connectedFromNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+            }
+            
+            for (j = 0; j < connectedToNodes.length; j++) {
+                allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+            }
+            
+            var go_from;
+            var go_to;
+                
+            if(degrees > 1){
+              for (i = 2; i <= degrees; i++) {
+                go_from = false;
+                go_to = false;
+                if(currentConnectedFromNodes.length > 0 && i <= degree_from){
+                  connectedFromNodes = edges.get({
+                    fields: ['from'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedFromNodes, item.to, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_from = true;
+                }
+
+                if(currentConnectedToNodes.length > 0 && i <= degree_to){
+                  connectedToNodes = edges.get({
+                    fields: ['to'],
+                    filter: function (item) {
+                      return indexOf.call(currentConnectedToNodes, item.from, true) > -1;
+                    },
+                    returnType :'Array'
+                  });
+                  go_to = true;
+                }
+
+                if(go_from === true){
+                  currentConnectedFromNodes = [];
+                  for (j = 0; j < connectedFromNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedFromNodes[j].from);
+                    currentConnectedFromNodes = currentConnectedFromNodes.concat(connectedFromNodes[j].from);
+                  }
+                }
+
+                if(go_to === true){
+                  currentConnectedToNodes = [];
+                  for (j = 0; j < connectedToNodes.length; j++) {
+                    allConnectedNodes = allConnectedNodes.concat(connectedToNodes[j].to);
+                    currentConnectedToNodes = currentConnectedToNodes.concat(connectedToNodes[j].to);
+                  } 
+                }
+                
+                if (go_from === false &&  go_to === false) { break;}
+              }
+            }
+            
+            allConnectedNodes = uniqueArray(allConnectedNodes, true, instance.network).concat(selectedNode);
+
+            var nodesWithLabel = [];
+            if(el_id.highlightLabelOnly === true){
+              if(degrees > 0){
+                // nodes to just label
+                for (j = 0; j < currentConnectedToNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedToNodes[j]));
+                }
+                
+                for (j = 0; j < currentConnectedFromNodes.length; j++) {
+                    nodesWithLabel = nodesWithLabel.concat(instance.network.getConnectedNodes(currentConnectedFromNodes[j]));
+                }
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              } else{
+                nodesWithLabel = currentConnectedToNodes;
+                nodesWithLabel = nodesWithLabel.concat(currentConnectedFromNodes);
+                nodesWithLabel = uniqueArray(nodesWithLabel, true, instance.network);
+              }
+            }
+            // all higher degree nodes get a different color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < nodesWithLabel.length; i++) {
+              if (allNodes[nodesWithLabel[i]].hiddenLabel !== undefined) {
+                allNodes[nodesWithLabel[i]].label = allNodes[nodesWithLabel[i]].hiddenLabel;
+                allNodes[nodesWithLabel[i]].hiddenLabel = undefined;
+                if(have_cluster_nodes){
+                  if(indexOf.call(nodes_in_clusters, nodesWithLabel[i], true) > -1){
+                    array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(nodesWithLabel[i])[0]);
+                  }
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                instance.network.body.nodes[array_cluster_id[i]].setOptions({label : instance.network.body.nodes[array_cluster_id[i]].options.hiddenLabel, hiddenLabel:undefined})
+              }
+            }
+
+            // all in degree nodes get their own color and their label back
+            array_cluster_id = [];
+            for (i = 0; i < allConnectedNodes.length; i++) {
+              resetOneNode(allNodes[allConnectedNodes[i]], options, instance.network);
+              if(have_cluster_nodes){
+                if(indexOf.call(nodes_in_clusters, allConnectedNodes[i], true) > -1){
+                  array_cluster_id = array_cluster_id.concat(instance.network.clustering.findNode(allConnectedNodes[i])[0]);
+                }
+              }
+            }
+            
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 resetOneCluster(instance.network.body.nodes[array_cluster_id[i]], options, instance.network);
+              }
+            }
+             
+            if (window.Shiny){ 
+              Shiny.onInputChange(el.id + '_highlight_color_id', uniqueShiny(allConnectedNodes));
+            }
+            if(el_id.highlightLabelOnly === true){
+              if (window.Shiny){
+                Shiny.onInputChange(el.id + '_highlight_label_id', nodesWithLabel.filter(function(x) {return !allConnectedNodes.includes(x)}));
+              }
+            }  
+            
+            // set some edges as hard to read
+            var edgesHardToRead = edges.get({
+              fields: ['id', 'color', 'hiddenColor', 'hiddenLabel', 'label'],
+              filter: function (item) {
+                return ((indexOf.call(allConnectedNodes, item.from, true) === -1)  || (indexOf.call(allConnectedNodes, item.to, true) === -1)) ;
+              },
+              returnType :'Array'
+            });
+
+            array_cluster_id = [];
+            for (i = 0; i < edgesHardToRead.length; i++) {
+              edgeAsHardToRead(edgesHardToRead[i], el_id.highlightColor, el_id.byselectionColor, instance.network, type = "edge")
+              if(have_cluster_nodes){
+                if(indexOf.call(edges_in_clusters, edgesHardToRead[i].id, true) > -1){
+                  var tmp_cluster_id = instance.network.clustering.getClusteredEdges(edgesHardToRead[i].id);
+                  if(tmp_cluster_id.length > 1){
+                    array_cluster_id = array_cluster_id.concat(tmp_cluster_id[0]);
+                  }
+                }
+              }
+            }
+
+            if(array_cluster_id.length > 0){
+              array_cluster_id = uniqueArray(array_cluster_id, false, instance.network);
+              for (i = 0; i < array_cluster_id.length; i++) {
+                 edgeAsHardToRead(instance.network.body.edges[array_cluster_id[i]].options, el_id.highlightColor, el_id.byselectionColor, instance.network, type = "cluster");
+              }
+            }
+            
+            edges.update(edgesHardToRead);
+            
+          }
+
+          if(update){
+            if(!(action_type == "hover")){
+               is_clicked = true;
+            }
+            // transform the object into an array
+            var updateArray = [];
+            for (nodeId in allNodes) {
+              if (allNodes.hasOwnProperty(nodeId)) {
+                updateArray.push(allNodes[nodeId]);
+              }
+            }
+            nodes.update(updateArray);
+          }else{
+            is_clicked = false;
+          }
+        
+        }
+        else if (el_id.highlightActive === true | el_id.selectActive === true) {
+          // reset nodeSelect list if actived
+          if(el_id.idselection){
+            resetList("nodeSelect", el.id, 'selected');
+          }
+          //reset nodes
+          resetAllNodes(nodes, update, options, instance.network, false)
+          el_id.highlightActive = false;
+          is_clicked = false;
+          
+          if (window.Shiny){
+            Shiny.onInputChange(el.id + '_highlight_label_id', null)
+            Shiny.onInputChange(el.id + '_highlight_color_id', null)
+          }
+        }
+      }
+      // reset selectedBy list if actived
+      if(el_id.byselection && reset_selectedBy){
+        resetList("selectedBy", el.id, 'selectedBy');
+      }
+    }
+    
+    function onClickIDSelection(selectedItems) {
+      var selectNode;
+      if(el_id.idselection){
+        if (selectedItems.nodes.length !== 0) {
+          selectNode = document.getElementById('nodeSelect'+el.id);
+          if(x.idselection.values !== undefined){
+            if(indexOf.call(x.idselection.values, selectedItems.nodes[0], true) > -1){
+              selectNode.value = selectedItems.nodes;
+            }else{
+              selectNode.value = "";
+            }
+          }else{
+            selectNode.value = selectedItems.nodes;
+          }
+          if (window.Shiny){
+            changeInput('selected', selectNode.value);
+          }
+        }else{
+          resetList("nodeSelect", el.id, 'selected');
+        } 
+      }
+      if(el_id.byselection){
+        // reset selectedBy list if actived
+        if (selectedItems.nodes.length === 0) {
+          resetList("selectedBy", el.id, 'selectedBy');
+          selectedHighlight("");
+        }
+      }
+    }
+    
+    // shared click function (selectedNodes)
+    document.getElementById("graph"+el.id).myclick = function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        }
+    };
+    
+    // Set event in relation with highlightNearest      
+    instance.network.on("click", function(params){
+        if(el_id.highlight && x.nodes){
+          neighbourhoodHighlight(params.nodes, "click", el_id.highlightAlgorithm, true);
+        }else if((el_id.idselection || el_id.byselection) && x.nodes){
+          onClickIDSelection(params)
+        } 
+    });
+    
+    instance.network.on("hoverNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([params.node], "hover", el_id.highlightAlgorithm, true);
+      } 
+    });
+
+    instance.network.on("blurNode", function(params){
+      if(el_id.hoverNearest && x.nodes){
+        neighbourhoodHighlight([], "hover", el_id.highlightAlgorithm, true);
+      }      
+    });
+    
+    //*************************
+    //collapse
+    //*************************
+    instance.network.on("doubleClick", function(params){
+      if(el_id.collapse){
+        collapsedNetwork(params.nodes, el_id.collapseFit, el_id.collapseResetHighlight, 
+          el_id.clusterOptions, el_id.collapseLabelSuffix,
+          el_id.tree, instance.network, el.id) 
+      }
+    }); 
+    
+    if(el_id.collapse){
+      instance.network.on("doubleClick", networkOpenCluster);
+    }
+    
+    //*************************
+    //footer
+    //*************************
+    var div_footer = document.createElement('div');
+    div_footer.id = "footer"+el.id;
+    div_footer.setAttribute('style',  'font-family:Georgia, Times New Roman, Times, serif;font-size:12px;text-align:center;background-color: inherit;');
+    div_footer.style.display = 'none';
+
+    document.getElementById("graph" + el.id).appendChild(div_footer);  
+    if(x.footer !== null){
+      div_footer.innerHTML = x.footer.text;
+      div_footer.setAttribute('style',  x.footer.style + ';background-color: inherit;');
+      div_footer.style.display = 'block'; 
+    }
+    
+    //*************************
+    // export
+    //*************************
+    if(x.export !== undefined){
+      
+      var downloaddiv = document.createElement('div');
+      downloaddiv.setAttribute('style', 'float:right; width:100%;background-color: inherit;');
+      
+      var downloadbutton = document.createElement("button");
+      downloadbutton.setAttribute('style', x.export.css);
+      downloadbutton.style.position = "relative";
+      downloadbutton.id = "download"+el.id;
+      downloadbutton.appendChild(document.createTextNode(x.export.label)); 
+      downloaddiv.appendChild(downloadbutton);
+      
+      var hr = document.createElement("hr");
+      hr.setAttribute('style', 'height:5px; visibility:hidden; margin-bottom:-1px;');
+      downloaddiv.appendChild(hr);  
+      
+      document.getElementById("maindiv"+el.id).appendChild(downloaddiv);
+      
+      document.getElementById("download"+el.id).onclick = function() {
+
+      // height control for export
+      var addHeightExport = document.getElementById("graph" + el.id).offsetHeight + idList.offsetHeight + byList.offsetHeight + downloaddiv.offsetHeight;
+      if(div_title.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_title.offsetHeight;
+      }
+      if(div_subtitle.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_subtitle.offsetHeight;
+      }
+      if(div_footer.style.display !== 'none'){
+        addHeightExport = addHeightExport + div_footer.offsetHeight;
+      } else {
+        addHeightExport = addHeightExport + 15;
+      }
+
+      downloadbutton.style.display = 'none';
+      var export_background = x.export.background;
+      if(x.background !== "transparent" && x.background !== "rgba(0, 0, 0, 0)"){
+        export_background = x.background
+      }
+      
+      if(x.export.type !== "pdf"){
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            canvas.toBlobHD(function(blob) {
+              saveAs(blob, x.export.name);
+            }, "image/"+x.export.type);
+          }
+        });
+      } else {
+        html2canvas(el_id, {
+          background: export_background,
+          height : addHeightExport,
+          onrendered: function(canvas) {
+            var myImage = canvas.toDataURL("image/png", 1.0);
+            //var imgWidth = (canvas.width * 25.4) / 24;
+            //var imgHeight = (canvas.height * 25.4) / 24; 
+            var table = new jsPDF('l', 'pt', [canvas.width, canvas.height]);
+            table.addImage(myImage, 'JPEG', 0, 0, canvas.width, canvas.height);
+            table.save(x.export.name);
+          } 
+        });
+      }
+
+      downloadbutton.style.display = 'block';
+      };
+    }
+
+    //*************************
+    // dataManipulation
+    //*************************
+    function clearPopUp() {
+      if(x.opts_manipulation.tab_add_node){
+        document.getElementById('addnode-saveButton').onclick = null;
+        document.getElementById('addnode-cancelButton').onclick = null;
+        document.getElementById('addnode-popUp').style.display = 'none';
+      }
+
+      if(x.opts_manipulation.tab_edit_node){
+        document.getElementById('editnode-saveButton').onclick = null;
+        document.getElementById('editnode-cancelButton').onclick = null;
+        document.getElementById('editnode-popUp').style.display = 'none';
+      }
+      
+      if(x.opts_manipulation.tab_edit_edge){
+        document.getElementById('editedge-saveButton').onclick = null;
+        document.getElementById('editedge-cancelButton').onclick = null;
+        document.getElementById('editedge-popUp').style.display = 'none';
+      }
+    }
+
+    function saveNode(data, callback, cmd) {
+      var iname;
+      var prediv;
+      if(cmd === "addNode"){
+        iname = "addNodeCols";
+        prediv = 'addnode-';
+      } else  {
+        iname = "editNodeCols";
+        prediv = 'editnode-';
+      }
+      var obj = {id : data.id}
+      for (var nodecol = 0; nodecol < x.opts_manipulation[iname].length; nodecol++){
+        var add_node_val = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).value;
+        var add_node_type = document.getElementById(prediv + x.opts_manipulation[iname][nodecol]).type;
+        if(add_node_type && add_node_type === "number"){
+          add_node_val = parseFloat(add_node_val)
+        }
+        if(add_node_val !== "undefined"){
+          obj[x.opts_manipulation[iname][nodecol]] = add_node_val
+        }
+      }
+
+      var update_obj = clone(obj);
+      update_obj.x = data.x;
+      update_obj.y = data.y;
+      nodes.update(update_obj);
+      
+      if (window.Shiny){
+        obj.cmd = cmd;
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      clearPopUp();
+      callback(null);
+    }
+
+    function saveEdge(data, callback, cmd) {
+      if(cmd === "editEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "addEdge"){
+        callback(data); //must be first called for egde id !
+        if (window.Shiny){
+          var obj = {cmd: cmd, id: data.id, from: data.from, to: data.to};
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+      } else if(cmd === "editEdgeCols"){
+        for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+          var add_edge_val = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).value;
+          var add_edge_type = document.getElementById("editedge-" + x.opts_manipulation.editEdgeCols[edgecol]).type;
+          if(add_edge_type && add_edge_type === "number"){
+            add_edge_val = parseFloat(add_edge_val)
+          }
+          if(add_edge_val !== "undefined"){
+            data[x.opts_manipulation.editEdgeCols[edgecol]] = add_edge_val
+          }
+        }
+        if (window.Shiny){
+          var obj = {cmd: "editEdge", id : data.id}
+          for (var edgecol = 0; edgecol < x.opts_manipulation.editEdgeCols.length; edgecol++){
+            if(data[x.opts_manipulation.editEdgeCols[edgecol]] !== "undefined"){
+              obj[x.opts_manipulation.editEdgeCols[edgecol]] = data[x.opts_manipulation.editEdgeCols[edgecol]];
+            }
+          }
+          Shiny.onInputChange(el.id + '_graphChange', obj);
+        }
+        callback(data);
+        clearPopUp();
+      }
+    }
+
+    function deleteSubGraph(data, callback) {
+      if (window.Shiny){
+        var obj = {cmd: "deleteElements", nodes: data.nodes, edges: data.edges}
+        Shiny.onInputChange(el.id + '_graphChange', obj);
+      }
+      callback(data);
+    }
+
+    function cancelEdit(callback) {
+      clearPopUp();
+      callback(null);
+    }
+    
+    //*************************
+    // CLUSTERING
+    //*************************
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringHubsize || x.clusteringConnection){
+      
+      var clusterbutton = document.createElement("input");
+      clusterbutton.id = "backbtn"+el.id;
+      clusterbutton.setAttribute('type', 'button');  
+      clusterbutton.setAttribute('value', 'Reinitialize clustering'); 
+      clusterbutton.setAttribute('style', 'background-color:#FFFFFF;border: none');
+      el_id.appendChild(clusterbutton);
+      
+      clusterbutton.onclick =  function(){
+        // reset some parameters / data before
+        if (el_id.selectActive === true | el_id.highlightActive === true) {
+          //reset nodes
+          neighbourhoodHighlight([], "click", el_id.highlightAlgorithm, true);
+          if (el_id.selectActive === true){
+            el_id.selectActive = false;
+            resetList('selectedBy',el.id, 'selectedBy');
+          }
+          if (el_id.highlightActive === true){
+            el_id.highlightActive = false;
+            resetList('nodeSelect', el.id, 'selected');
+          }
+        }
+        //instance.network.setData(data);
+        if(x.clusteringColor){
+          clusterByColor();
+        }
+        if(x.clusteringGroup){
+          clusterByGroup(x.clusteringGroup.groups);
+        }
+        if(x.clusteringHubsize){
+          clusterByHubsize();
+        }
+        if(x.clusteringConnection){
+          clusterByConnection();
+        }
+        instance.network.fit();
+      }
+    }
+    
+    if(x.clusteringGroup || x.clusteringColor || x.clusteringOutliers || x.clusteringHubsize || x.clusteringConnection){
+      // if we click on a node, we want to open it up!
+      instance.network.on("doubleClick", function (params){
+        if (params.nodes.length === 1) {
+          if (instance.network.isCluster(params.nodes[0]) === true) {
+            is_clicked = false;
+            instance.network.openCluster(params.nodes[0], {releaseFunction : function(clusterPosition, containedNodesPositions) {
+              return containedNodesPositions;
+            }});
+            // must be better...
+            resetAllEdges(edges, el_id.highlightColor, el_id.byselectionColor, instance.network);
+            resetAllNodes(nodes, true, options, instance.network, true);
+          } else {
+            if(x.clusteringGroup){
+              var array_group = nodes.get({
+                fields: ['group'],
+                filter: function (item) {
+                  return  item.id === params.nodes[0] ;
+                },
+                returnType :'Array'
+              });
+            
+              clusterByGroup([array_group[0].group]);
+            }
+          }
+        }
+      });
+    }
+    //*************************
+    //clustering Connection
+    //*************************
+    if(x.clusteringConnection){
+      
+      function clusterByConnection() {
+        for (var i = 0; i < x.clusteringConnection.nodes.length; i++) {
+          instance.network.clusterByConnection(x.clusteringConnection.nodes[i])
+        }
+      }
+      clusterByConnection();
+    }
+    
+    //*************************
+    //clustering hubsize
+    //*************************
+    if(x.clusteringHubsize){
+      
+      function clusterByHubsize() {
+        var clusterOptionsByData = {
+          processProperties: function(clusterOptions, childNodes) {
+            var cluster_level = 9999999
+                  for (var i = 0; i < childNodes.length; i++) {
+                      //totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(i === 0){
+                        //clusterOptions.shape =  childNodes[i].shape;
+                        clusterOptions.color =  childNodes[i].color.background;
+                      }else{
+                        //if(childNodes[i].shape !== clusterOptions.shape){
+                          //clusterOptions.shape = 'database';
+                        //}
+                        if(childNodes[i].color.background !== clusterOptions.color){
+                          clusterOptions.color = 'grey';
+                        }
+                      }
+                  }
+            clusterOptions.label = "[" + childNodes.length + "]";
+            if(cluster_level !== 9999999){
+              clusterOptions.level = cluster_level
+            }
+            return clusterOptions;
+          },
+          clusterNodeProperties: {borderWidth:3, shape:'box', font:{size:30}}
+        }
+        if(x.clusteringHubsize.size > 0){
+          instance.network.clusterByHubsize(x.clusteringHubsize.size, clusterOptionsByData);
+        }else{
+          instance.network.clusterByHubsize(undefined, clusterOptionsByData);
+        }
+      }
+      
+      clusterByHubsize();
+    }
+    
+    if(x.clusteringColor){
+      
+    //*************************
+    //clustering color
+    //*************************
+    function clusterByColor() {
+        var colors = x.clusteringColor.colors
+        var clusterOptionsByData;
+        for (var i = 0; i < colors.length; i++) {
+          var color = colors[i];
+          var sh = x.clusteringColor.shape[i];
+          var force = x.clusteringColor.force[i];
+          clusterOptionsByData = {
+              joinCondition: function (childOptions) {
+                  return childOptions.color.background == color; // the color is fully defined in the node.
+              },
+              processProperties: function (clusterOptions, childNodes, childEdges) {
+                  var totalMass = 0;
+                  var cluster_level = 9999999;
+                  for (var i = 0; i < childNodes.length; i++) {
+                      totalMass += childNodes[i].mass;
+                      if(childNodes[i].level){
+                        cluster_level = Math.min(cluster_level, childNodes[i].level)
+                      }
+                      if(force === false){
+                        if(i === 0){
+                          clusterOptions.shape =  childNodes[i].shape;
+                        }else{
+                          if(childNodes[i].shape !== clusterOptions.shape){
+                            clusterOptions.shape = sh;
+                          }
+                        }
+                      } else {
+                        clusterOptions.shape = sh;
+                      }
+
+                  }
+                  clusterOptions.value = totalMass;
+                  if(cluster_level !== 9999999){
+                    clusterOptions.level = cluster_level
+                  }
+                  return clusterOptions;
+              },
+              clusterNodeProperties: {id: 'cluster:' + color, borderWidth: 3, color:color, label: x.clusteringColor.label + color}
+          }
+          instance.network.cluster(clusterOptionsByData);
+        }
+      }
+      
+      clusterByColor();
+    }
+
+    //*************************
+    //clustering groups
+    //*************************
+    if(x.clusteringGroup){
+      
+      function clusterByGroup(groups) {
+        var clusterOptionsByData;
+        for (var i = 0; i < groups.length; i++) {
+          var group = groups[i];
+          var j = x.clusteringGroup.groups.indexOf(group);
+          if(j !== -1) {
+            var col = x.clusteringGroup.color[j];
+            var sh = x.clusteringGroup.shape[j];
+            var force = x.clusteringGroup.force[j];
+            var sc_size = x.clusteringGroup.scale_size[j];
+            
+            clusterOptionsByData = {
+                joinCondition: function (childOptions) {
+                    return childOptions.group == group; //
+                },
+                processProperties: function (clusterOptions, childNodes, childEdges) {
+                    var totalMass = 0;
+                    var cluster_level = 9999999;
+                    for (var i = 0; i < childNodes.length; i++) {
+                        totalMass += childNodes[i].mass;
+                        if(childNodes[i].level){
+                          cluster_level = Math.min(cluster_level, childNodes[i].level)
+                        }
+                        if(force === false){
+                          if(i === 0){
+                            clusterOptions.shape =  childNodes[i].shape;
+                            clusterOptions.color =  childNodes[i].color.background;
+                          }else{
+                            if(childNodes[i].shape !== clusterOptions.shape){
+                              clusterOptions.shape = sh;
+                            }
+                            if(childNodes[i].color.background !== clusterOptions.color){
+                              clusterOptions.color = col;
+                            }
+                          }
+                        } else {
+                          clusterOptions.shape = sh;
+                          clusterOptions.color = col;
+                        }
+                    }
+                    if(sc_size){
+                       clusterOptions.value = totalMass;
+                    }
+                    if(cluster_level !== 9999999){
+                      clusterOptions.level = cluster_level
+                    }
+                    return clusterOptions;
+                },
+                clusterNodeProperties: {id: 'cluster:' + group, borderWidth: 3, label:x.clusteringGroup.label + group}
+            }
+            instance.network.cluster(clusterOptionsByData);
+          }
+
+        }
+      }
+      clusterByGroup(x.clusteringGroup.groups);
+    }
+  
+    //*************************
+    //clustering by zoom
+    //*************************
+    if(x.clusteringOutliers){
+      
+      clusterFactor = x.clusteringOutliers.clusterFactor;
+      
+      // set the first initial zoom level
+      instance.network.on('initRedraw', function() {
+        if (lastClusterZoomLevel === 0) {
+          lastClusterZoomLevel = instance.network.getScale();
+        }
+      });
+
+      // we use the zoom event for our clustering
+      instance.network.on('zoom', function (params) {
+        if(ctrlwait === 0){
+        if (params.direction == '-') {
+          if (params.scale < lastClusterZoomLevel*clusterFactor) {
+            makeClusters(params.scale);
+            lastClusterZoomLevel = params.scale;
+          }
+        }
+        else {
+          openClusters(params.scale);
+        }
+        }
+      });
+    }
+
+    // make the clusters
+    function makeClusters(scale) {
+        ctrlwait = 1;
+        var clusterOptionsByData = {
+            processProperties: function (clusterOptions, childNodes) {
+                clusterIndex = clusterIndex + 1;
+                var childrenCount = 0;
+                var cluster_level = 9999999;
+                for (var i = 0; i < childNodes.length; i++) {
+                    childrenCount += childNodes[i].childrenCount || 1;
+                    if(childNodes[i].level){
+                      cluster_level = Math.min(cluster_level, childNodes[i].level)
+                    }
+                }
+                clusterOptions.childrenCount = childrenCount;
+                clusterOptions.label = "# " + childrenCount + "";
+                clusterOptions.font = {size: childrenCount*5+30}
+                clusterOptions.id = 'cluster:' + clusterIndex;
+                clusters.push({id:'cluster:' + clusterIndex, scale:scale});
+                
+                if(cluster_level !== 9999999){
+                  clusterOptions.level = cluster_level
+                }
+                return clusterOptions;
+            },
+            clusterNodeProperties: {borderWidth: 3, shape: 'database', font: {size: 30}}
+        }
+        instance.network.clusterOutliers(clusterOptionsByData);
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+
+    // open them back up!
+    function openClusters(scale) {
+        ctrlwait = 1;
+        var newClusters = [];
+        var declustered = false;
+        for (var i = 0; i < clusters.length; i++) {
+            if (clusters[i].scale < scale) {
+                instance.network.openCluster(clusters[i].id);
+                lastClusterZoomLevel = scale;
+                declustered = true;
+            }
+            else {
+                newClusters.push(clusters[i])
+            }
+        }
+        clusters = newClusters;
+        if (x.clusteringOutliers.stabilize) {
+            instance.network.stabilize();
+        };
+        ctrlwait = 0;
+    }
+    
+    //******************
+    // init selection
+    //******************
+    if(el_id.idselection && x.nodes && x.idselection.selected !== undefined){ 
+      onIdChange(''+ x.idselection.selected, true);
+    }
+      
+    if(el_id.byselection && x.nodes && x.byselection.selected !== undefined){ 
+      onByChange(x.byselection.selected);
+      selectNode = document.getElementById('selectedBy'+el.id);
+      selectNode.value = x.byselection.selected;
+    }
+    
+    // try to fix icons loading css bug...
+    function iconsRedraw() {
+      setTimeout(function(){
+        if(instance.network)
+          instance.network.redraw();
+        if(instance.legend)
+          instance.legend.redraw();
+      }, 250);
+    };
+    
+    if(x.iconsRedraw !== undefined){
+      if(x.iconsRedraw){
+        iconsRedraw();
+        instance.network.once("stabilized", function(){iconsRedraw();})
+      }
+    }
+  }, 
+  
+  resize: function(el, width, height, instance) {
+      if(instance.network)
+        instance.network.fit();
+      if(instance.legend)
+        instance.legend.fit();
+  }
+  
+});
+</script>
+
+</head>
+<body style="background-color: white;">
+<div id="htmlwidget_container">
+  <div class="visNetwork html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-5a2424407fd10da631bc" style="width:960px;height:500px;"></div>
+</div>
+<script type="application/json" 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index 0000000..975f4d9
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+"Drug_set","mean_NES","sd_NES","Fisher_p","types","N_types","N_sig","sig_types","adj_Fisher_p"
+"TGF beta receptor inhibitor",0.913333333333333,1.00986410726964,0.00295420917678714,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC15",0.0204332801394444
+"opioid receptor agonist",0.821833333333333,1.29748461776367,3.18461727594471e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H520, HCC15",0.000528646467806823
+"p38 MAPK inhibitor",0.770416666666667,0.865615016078514,0.204841463769956,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.472273374802954
+"serotonin receptor antagonist",0.660333333333333,1.09067846552112,0.0474600935910376,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.164132823669005
+"DNA methyltransferase inhibitor",0.650166666666667,1.20612805240069,0.00793405531467982,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.0439017727412283
+"acetylcholine receptor agonist",0.638416666666667,1.2013921060271,0.00332866118057934,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, HCC95, H1648",0.0212522213836988
+"cytochrome P450 inhibitor",0.624916666666667,1.2004672922229,0.0773388332553046,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H460",0.246889352315011
+"FGFR inhibitor",0.61975,1.19126801236024,0.0124836168362864,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0609494233771628
+"DNA polymerase inhibitor",0.615916666666667,0.969000746630103,0.289899084157724,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879
+"serotonin receptor agonist",0.549,1.63596692441436,0.000342986783840368,"H1650, H1975, H1648, H2126, H520, H1299, HCC44, A549, H1703, HCC15",10,5,"H1650, H1975, H2126, H520, HCC44",0.00355848788234381
+"RET tyrosine kinase inhibitor",0.454416666666667,1.11954101458291,0.15853229885422,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.395508587605083
+"MEK inhibitor",0.424916666666667,1.52881471963404,0.000168928610080343,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H520, HCC44",0.00200301066238121
+"ALK tyrosine kinase receptor inhibitor",0.4175,0.979026835921542,0.59787788919107,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.842195416188551
+"NFkB pathway inhibitor",0.412833333333333,0.935240157133531,0.701908331500717,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.910287367414993
+"dopamine receptor antagonist",0.3865,0.952093721513515,0.720138394834125,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.919561334942037
+"proteasome inhibitor",0.365166666666667,1.0829952432812,0.244445707548859,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.53392088754093
+"HSP inhibitor",0.345083333333333,1.37469411198097,0.000816485868795425,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, HCC95",0.00752981412333559
+"bromodomain inhibitor",0.322333333333333,1.30509549168796,0.00469301275409585,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.027822861327854
+"FLT3 inhibitor",0.320166666666667,1.00432617241913,0.67272001519146,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.900576794530503
+"potassium channel blocker",0.3155,1.16333912041627,0.145405949708937,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H2126",0.380342911769697
+"ATPase inhibitor",0.314166666666667,1.18801613344825,0.117507434219084,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.325103901339466
+"sodium channel blocker",0.29275,0.848811696110831,0.966336603040099,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476
+"bacterial DNA gyrase inhibitor",0.290166666666667,1.17881302652929,0.0943927860836075,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.281356632742163
+"RAF inhibitor",0.280166666666667,1.11642553253541,0.319709981358538,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879
+"antioxidant",0.277166666666667,1.32589927173518,0.0107472975039914,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0557516058019556
+"HMGCR inhibitor",0.271583333333333,1.73015613895149,1.55365513866256e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,5,"HCC95, H1648, H520, H460, H1703",6.4476688254496e-05
+"calcium channel blocker",0.251666666666667,0.952012732280531,0.868582317371563,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917
+"phosphodiesterase inhibitor",0.246083333333333,1.00378288655134,0.701629779750684,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.910287367414993
+"HCV inhibitor",0.24425,1.23272662493279,0.0983053295123219,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.281356632742163
+"benzodiazepine receptor agonist",0.229416666666667,0.907554401908912,0.94361920760397,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476
+"PARP inhibitor",0.228416666666667,1.11180790184549,0.33098974305323,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.602943525907879
+"KIT inhibitor",0.198833333333333,1.14213554627312,0.315300755570576,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879
+"AP inhibitor",0.196833333333333,1.07903541380365,0.444318244172752,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H520",0.737568285326769
+"PDGFR tyrosine kinase receptor inhibitor",0.191333333333333,1.07097893480118,0.547869434390149,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.833620703105775
+"PPAR receptor agonist",0.189083333333333,1.2938439879489,0.0418206406591395,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,2,"H1650, H460",0.150917964117764
+"progesterone receptor agonist",0.174,1.04605127633748,0.625673367330335,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.865514824806963
+"BCL inhibitor",0.150166666666667,1.06292519477947,0.575847572613479,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.838514886437171
+"MDM inhibitor",0.145,1.65976723450226,7.89329835102124e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"HCC95, H520, HCC44",0.000163785940783691
+"VEGFR inhibitor",0.134583333333333,0.885227290621231,0.973314179502101,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476
+"glycogen synthase kinase inhibitor",0.128166666666667,1.00884495910678,0.758129022004787,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.953404679187838
+"tyrosine kinase inhibitor",0.127916666666667,0.828150892962841,0.995163006002476,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476
+"AKT inhibitor",0.1195,1.18522023269939,0.211749384719054,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.475005376531932
+"microtubule inhibitor",0.0925833333333333,1.12085344580355,0.44055380916358,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.737568285326769
+"DNA inhibitor",0.0918333333333333,0.924596209983121,0.95776117019698,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476
+"histamine receptor antagonist",0.0738333333333333,0.974568700254195,0.880207313818108,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917
+"phosphatase inhibitor",0.06675,1.05524647056333,0.643564991193952,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.875670397854066
+"cyclooxygenase inhibitor",0.0648333333333334,0.877587378020335,0.986282704690237,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476
+"bacterial 50S ribosomal subunit inhibitor",0.0401666666666667,0.999421544816012,0.834133979759095,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917
+"protein synthesis inhibitor",0.00633333333333332,0.970586264568841,0.883631795253734,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917
+"adrenergic receptor agonist",0.00149999999999991,1.09716862878958,0.527743404741443,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.826466086670562
+"glutamate receptor antagonist",-0.000666666666666704,1.08539011280263,0.573166268556998,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.838514886437171
+"growth factor receptor inhibitor",-0.0109166666666666,1.15885040671845,0.298080376945264,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879
+"tubulin polymerization inhibitor",-0.0303333333333334,1.29596649320696,0.0352119261448867,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.139170946191695
+"Aurora kinase inhibitor",-0.0324166666666666,1.09028140306931,0.526306866263577,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.826466086670562
+"JAK inhibitor",-0.0428333333333334,0.950117488747704,0.919381554363839,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476
+"sterol demethylase inhibitor",-0.07425,1.35497401014994,0.0152566557027169,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.0703501346291945
+"PI3K inhibitor",-0.103,0.951020122146358,0.876586807084671,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917
+"HDAC inhibitor",-0.10475,1.12594252436873,0.366112865007304,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.646539740332048
+"ribonucleotide reductase inhibitor",-0.15,1.40035015101743,0.00280732489417635,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.0204332801394444
+"CDK inhibitor",-0.1545,1.23740994162661,0.095367777261869,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.281356632742163
+"Abl kinase inhibitor",-0.172083333333333,0.988868357663384,0.792156974208221,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.979765350307264
+"retinoid receptor agonist",-0.173166666666667,1.14609343053485,0.301230536905824,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879
+"CC chemokine receptor antagonist",-0.20775,1.07228999851211,0.552399261094188,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.833620703105775
+"androgen receptor antagonist",-0.226583333333333,1.17285521530179,0.174829153168707,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.414594848942935
+"adenosine receptor antagonist",-0.22725,1.27450982556218,0.162015566006902,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1299",0.395508587605083
+"MET inhibitor",-0.2415,1.24277354771861,0.0321086086443673,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"HCC95",0.133250725874124
+"estrogen receptor antagonist",-0.260333333333333,1.50406469477234,6.18068573204134e-05,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.000854994859599053
+"Bcr.Abl kinase inhibitor",-0.266916666666667,1.10478014746936,0.332711407152,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.602943525907879
+"glucocorticoid receptor agonist",-0.312083333333333,0.911319468815642,0.880453658120564,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.991100527108917
+"DNA synthesis inhibitor",-0.316583333333333,0.949657111165856,0.802699323143301,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.979765350307264
+"adrenergic receptor antagonist",-0.325666666666667,0.878351900212017,0.924528929198808,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476
+"topoisomerase inhibitor",-0.337333333333333,1.36859551985592,0.0012103587680913,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1975, H1299, H1703",0.0100459777751578
+"acetylcholine receptor antagonist",-0.391583333333333,1.53897719625928,2.6234296837352e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,3,"H1650, H2126, H460",7.25815545833406e-05
+"thymidylate synthase inhibitor",-0.40075,0.981132566800411,0.598669030784633,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.842195416188551
+"mTOR inhibitor",-0.417333333333333,1.01538244772672,0.334161472189909,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"A549",0.602943525907879
+"PLK inhibitor",-0.421666666666667,1.74493466058101,1.3541656713242e-06,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,6,"H1650, H1648, H2126, H520, H1299, H1703",6.4476688254496e-05
+"EGFR inhibitor",-0.451333333333333,1.1625235351153,0.0540564160985525,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.179467301447194
+"vitamin D receptor agonist",-0.45875,1.19189330860229,0.0405749206986854,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.150917964117764
+"protein tyrosine kinase inhibitor",-0.502083333333333,1.10066066592531,0.146638231043738,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.380342911769697
+"estrogen receptor agonist",-0.52825,0.982934301420543,0.400779022557223,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.693013726505198
+"src inhibitor",-0.532666666666667,0.947837570792623,0.493132394210983,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.802548798421796
+"DNA alkylating agent",-0.551,0.733577535097688,0.930470885321363,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,0,"",0.995163006002476
+"CHK inhibitor",-0.881833333333333,1.06082590751763,0.0254858350329839,"H1650, HCC95, H1975, H1648, H2126, H520, H460, H1299, HCC44, A549, H1703, HCC15",12,1,"H1650",0.111332858301982
diff --git a/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_results.csv b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_results.csv
new file mode 100644
index 0000000..a1b9600
--- /dev/null
+++ b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_results.csv
@@ -0,0 +1,995 @@
+"type","Rank_metric","Drug_set","ES","NES","p_value","Position_at_max","FDR_q_value","Leading_edge","minusLogP","minusLogFDR","sig"
+"H1650","Pearson.est","EGFR inhibitor",-0.56936,-1.51,0.0998,1075,0.499,"AST.1306, CNX.2006, gefitinib, ARRY.334543, WZ8040, dacomitinib, neratinib, PD.153035, lapatinib, AZD8931, rociletinib, osimertinib, XL.647, pelitinib, canertinib, vandetanib, WZ.3146, BMS.599626, AEE788, PD.168393, afatinib, poziotinib, TAK.285, icotinib, erlotinib, GW.583340",1.00086945871263,0.30189945437661,FALSE
+"H1650","Pearson.est","Abl kinase inhibitor",0.32161,0.812,0.7,327,0.861,"KW.2449, tozasertib, imatinib",0.154901959985743,0.0649968485463452,FALSE
+"H1650","Pearson.est","acetylcholine receptor agonist",0.67274,1.69,0.0297,467,0.201,"xanomeline, oxiracetam, nefiracetam, tremorine, nicotine",1.52724355068279,0.696803942579511,TRUE
+"H1650","Pearson.est","acetylcholine receptor antagonist",-0.717,-1.9,0.0067,1241,0.192,"hyoscyamine, diphemanil, iododexetimide, darifenacin",2.17392519729917,0.71669877129645,TRUE
+"H1650","Pearson.est","adenosine receptor antagonist",-0.2639,-0.711,0.786,1044,0.911,"MRS.1220, CGS.15943, theophylline",0.104577453960592,0.0404816230270017,FALSE
+"H1650","Pearson.est","adrenergic receptor agonist",-0.39144,-1.06,0.365,1335,0.857,"methyldopa, A61603, isoetharine, xylazine",0.437707135543525,0.0670191780768018,FALSE
+"H1650","Pearson.est","adrenergic receptor antagonist",-0.28236,-0.756,0.766,1287,0.932,"naftidrofuryl, metoprolol, prazosin, practolol",0.115771230367396,0.0305840876460186,FALSE
+"H1650","Pearson.est","AKT inhibitor",0.4296,1.07,0.358,445,0.631,"uprosertib, GDC.0068, ONC201, CCT128930, AT7867, palomid.529",0.446116973356126,0.199970640755866,FALSE
+"H1650","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.37475,-0.989,0.448,1391,0.861,"lorlatinib, AP26113",0.348721986001856,0.0649968485463452,FALSE
+"H1650","Pearson.est","androgen receptor antagonist",-0.56788,-1.45,0.112,1245,0.537,"enzalutamide, flutamide",0.950781977329818,0.270025714300444,FALSE
+"H1650","Pearson.est","antioxidant",0.3826,0.962,0.477,170,0.736,"mesna, benfotiamine",0.321481620959886,0.133122185662501,FALSE
+"H1650","Pearson.est","AP inhibitor",-0.32144,-0.854,0.63,972,0.931,"GDC.0152, birinapant, tanshinone.i",0.200659450546418,0.0310503190186574,FALSE
+"H1650","Pearson.est","ATPase inhibitor",0.47922,1.22,0.234,334,0.457,"evodiamine, ouabain, NMS.873, omeprazole, thonzonium, digoxin",0.630784142589857,0.34008379993015,FALSE
+"H1650","Pearson.est","Aurora kinase inhibitor",0.62846,1.58,0.0474,351,0.293,"barasertib, GSK1070916, PHA.680632, AMG900, CCT137690, danusertib, MK.8745, KW.2449, CCT129202, tozasertib, alisertib, ENMD.2076, SNS.314, barasertib.HQPA, PF.03814735",1.32422165832591,0.533132379645891,FALSE
+"H1650","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.39884,1.01,0.42,93,0.695,"valnemulin, azalomycin.b",0.3767507096021,0.158015195409886,FALSE
+"H1650","Pearson.est","bacterial DNA gyrase inhibitor",-0.23755,-0.634,0.904,1146,0.918,"sparfloxacin, sarafloxacin, lomefloxacin",0.0438315695246367,0.0371573187987575,FALSE
+"H1650","Pearson.est","BCL inhibitor",0.52502,1.32,0.175,326,0.387,"venetoclax, oridonin, gossypol, navitoclax",0.756961951313706,0.412289034981089,FALSE
+"H1650","Pearson.est","Bcr.Abl kinase inhibitor",0.2574,0.633,0.892,327,0.929,"tozasertib, imatinib",0.0496351456238769,0.0319842860063582,FALSE
+"H1650","Pearson.est","benzodiazepine receptor agonist",-0.31935,-0.828,0.645,1300,0.906,"gamma.aminobutyric.acid, indiplon, bentazepam",0.190440285364732,0.0428718023231869,FALSE
+"H1650","Pearson.est","bromodomain inhibitor",0.76472,1.94,0.00179,260,0.104,"I.BET.762, JQ1...., bromosporine, I.BET151",2.74714696902011,0.98296666070122,TRUE
+"H1650","Pearson.est","calcium channel blocker",0.31918,0.804,0.699,84,0.83,"cinnarazine",0.155522824254319,0.0809219076239261,FALSE
+"H1650","Pearson.est","CC chemokine receptor antagonist",-0.37991,-0.965,0.497,1066,0.868,"RS.504393, ZK811752, MK.0812, UNBS.5162",0.303643611266668,0.0614802748235081,FALSE
+"H1650","Pearson.est","CDK inhibitor",0.57382,1.47,0.095,386,0.345,"PHA.793887, indisulam, JNJ.7706621, alvocidib, R547, AZD5438, ribociclib, palbociclib, AT.7519, PHA.848125, TG.02, indirubin, aminopurvalanol.a, abemaciclib, kenpaullone, BMS.265246",1.02227639471115,0.462180904926726,FALSE
+"H1650","Pearson.est","CHK inhibitor",-0.81665,-2.19,0,1253,0.0229,"PF.477736, AZD7762, LY2606368, CHIR.124",Inf,1.64016451766011,TRUE
+"H1650","Pearson.est","cyclooxygenase inhibitor",-0.32134,-0.849,0.598,1136,0.903,"FR.122047, indoprofen, pterostilbene, metoxibutropate, FK.3311, naproxen",0.223298816011589,0.0443122496864942,FALSE
+"H1650","Pearson.est","cytochrome P450 inhibitor",-0.49631,-1.28,0.196,1105,0.754,"morin, clotrimazole, metyrapone",0.707743928643524,0.122628654130226,FALSE
+"H1650","Pearson.est","DNA alkylating agent",0.33373,0.841,0.626,371,0.881,"carmustine, estramustine, carboplatin, temozolomide, TH.302",0.20342566678957,0.0550240915879521,FALSE
+"H1650","Pearson.est","DNA inhibitor",0.31335,0.789,0.725,524,0.831,"carmustine, oxaliplatin, carboplatin, valrubicin, chlorambucil, pibenzimol, melphalan, mechlorethamine",0.139661993429006,0.080398976215889,FALSE
+"H1650","Pearson.est","DNA methyltransferase inhibitor",0.70879,1.77,0.0223,83,0.205,"decitabine, azacitidine, disulfiram",1.65169513695184,0.688246138944246,TRUE
+"H1650","Pearson.est","DNA polymerase inhibitor",0.51458,1.32,0.166,278,0.387,"trifluridine, foscarnet, idoxuridine",0.779891911959945,0.412289034981089,FALSE
+"H1650","Pearson.est","DNA synthesis inhibitor",-0.36679,-0.963,0.473,1112,0.829,"altretamine, nelarabine, artemisinin, artesunate, CB.10.277, estramustine.phosphate",0.325138859262188,0.0814454694497265,FALSE
+"H1650","Pearson.est","dopamine receptor antagonist",0.26904,0.684,0.838,216,0.913,"mesoridazine, ziprasidone, paliperidone, raclopride",0.0767559813697235,0.039529222465701,FALSE
+"H1650","Pearson.est","estrogen receptor agonist",-0.47954,-1.26,0.208,1175,0.721,"levonorgestrel, estradiol, estradiol.cypionate",0.681936665037238,0.142064735280571,FALSE
+"H1650","Pearson.est","estrogen receptor antagonist",-0.62301,-1.67,0.0383,1059,0.372,"raloxifene, toremifene, fulvestrant",1.41680122603138,0.429457060118102,FALSE
+"H1650","Pearson.est","FGFR inhibitor",0.33045,0.835,0.634,190,0.867,"dovitinib, nintedanib",0.197910742118267,0.0619809025237897,FALSE
+"H1650","Pearson.est","FLT3 inhibitor",0.53599,1.34,0.171,325,0.419,"sorafenib, KW.2449, dovitinib, tozasertib, TG.02, ENMD.2076, sunitinib, TG.101348, tandutinib",0.767003889607846,0.377785977033705,FALSE
+"H1650","Pearson.est","glucocorticoid receptor agonist",-0.276,-0.714,0.792,1316,0.937,"flumethasone.pivalate, deflazacort, triamcinolone.acetonide, clobetasol.propionate",0.101274818410506,0.0282604091122217,FALSE
+"H1650","Pearson.est","glutamate receptor antagonist",-0.45502,-1.23,0.219,1054,0.719,"CPP, SIB.1757, ACDPP, JNJ.16259685, tiletamine, kynurenic.acid, MTPG, LY456236, CGP.37849",0.659555885159882,0.143271109617117,FALSE
+"H1650","Pearson.est","glycogen synthase kinase inhibitor",0.56807,1.42,0.0986,354,0.396,"indirubin, CHIR.99021, tideglusib, kenpaullone",1.00612308505879,0.402304814074488,FALSE
+"H1650","Pearson.est","growth factor receptor inhibitor",0.43563,1.11,0.318,207,0.609,"danusertib, GSK1838705A, PHA.848125",0.497572880015567,0.215382707367125,FALSE
+"H1650","Pearson.est","HCV inhibitor",0.49394,1.25,0.219,9,0.453,"narlaprevir",0.659555885159882,0.343901797987168,FALSE
+"H1650","Pearson.est","HDAC inhibitor",0.18248,0.459,0.995,462,0.989,"vorinostat, resminostat, panobinostat, pyroxamide, R306465, givinostat, PCI.24781, belinostat, AR.42",0.00217691925427455,0.0048037084028206,FALSE
+"H1650","Pearson.est","histamine receptor antagonist",-0.39043,-1.06,0.364,1103,0.857,"tecastemizole, cimetidine, astemizole, famotidine, ICI.162846, BF2.649, lafutidine, chloropyramine",0.438898616350944,0.0670191780768018,FALSE
+"H1650","Pearson.est","HMGCR inhibitor",-0.61045,-1.58,0.0612,1111,0.446,"mevastatin, simvastatin, fluvastatin, pitavastatin",1.21324857785444,0.350665141287858,FALSE
+"H1650","Pearson.est","HSP inhibitor",0.65387,1.65,0.024,344,0.219,"PU.H71, NVP.AUY922, BIIB021, SNX.2112, tanespimycin, ganetespib, SNX.5422, NMS.E973, XL888",1.61978875828839,0.659555885159882,TRUE
+"H1650","Pearson.est","JAK inhibitor",0.3215,0.807,0.695,353,0.847,"AZD1480, tozasertib, AZ960, TG.02, filgotinib, TG.101348, atiprimod",0.158015195409886,0.0721165896692931,FALSE
+"H1650","Pearson.est","KIT inhibitor",0.43683,1.09,0.318,328,0.619,"OSI.930, sorafenib, KI.8751, sunitinib, tandutinib, imatinib, masitinib",0.497572880015567,0.208309350979882,FALSE
+"H1650","Pearson.est","MDM inhibitor",0.54515,1.39,0.12,201,0.365,"idasanutlin, nutlin.3, CGM097",0.920818753952375,0.437707135543525,FALSE
+"H1650","Pearson.est","MEK inhibitor",0.61023,1.55,0.0679,132,0.309,"PD.0325901, cobimetinib, trametinib, AS.703026, Ro.4987655, AZD8330, refametinib, MEK162, TAK.733",1.1681302257195,0.510041520575165,FALSE
+"H1650","Pearson.est","MET inhibitor",-0.30244,-0.814,0.671,1169,0.897,"PHA.665752, PF.04217903",0.173277479831008,0.0472075569559079,FALSE
+"H1650","Pearson.est","microtubule inhibitor",0.3299,0.831,0.664,72,0.851,"vinflunine, vinblastine",0.177831920631982,0.0700704399154121,FALSE
+"H1650","Pearson.est","mTOR inhibitor",-0.26131,-0.677,0.831,1370,0.899,"PI.103, sirolimus, SB.2343, deforolimus",0.080398976215889,0.0462403082667712,FALSE
+"H1650","Pearson.est","NFkB pathway inhibitor",0.37168,0.949,0.509,125,0.735,"betulinic.acid, curcumin, bortezomib",0.293282217663241,0.133712660915805,FALSE
+"H1650","Pearson.est","opioid receptor agonist",0.79244,2.02,0.00533,87,0.0813,"salvinorin.a, trimebutine",2.27327279097343,1.08990945440593,TRUE
+"H1650","Pearson.est","p38 MAPK inhibitor",0.41458,1.05,0.401,175,0.645,"skepinone.l, talmapimod",0.396855627379818,0.190440285364732,FALSE
+"H1650","Pearson.est","PARP inhibitor",0.72924,1.84,0.012,295,0.159,"niraparib, talazoparib, olaparib, endo.IWR.1, PJ.34",1.92081875395238,0.798602875679548,TRUE
+"H1650","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.49502,1.26,0.221,400,0.458,"sorafenib, crenolanib, CP.673451, axitinib, KI.8751, dovitinib, nintedanib, sunitinib, tandutinib, imatinib, masitinib, trapidil, SU014813",0.655607726314889,0.339134521996131,FALSE
+"H1650","Pearson.est","phosphatase inhibitor",-0.51624,-1.37,0.138,1351,0.627,"bis.maltolato.oxovanadium.IV., mycophenolate.mofetil, BVT.948",0.860120913598763,0.202732459169284,FALSE
+"H1650","Pearson.est","phosphodiesterase inhibitor",-0.2236,-0.597,0.929,1144,0.927,"EMD.53998, enoximone, GSK256066",0.0319842860063582,0.0329202658555029,FALSE
+"H1650","Pearson.est","PI3K inhibitor",0.24157,0.613,0.914,385,0.927,"CH5132799, alpelisib, buparlisib, voxtalisib, AZD6482, LY303511, PIK.75, CUDC.907, GDC.0941",0.0390538042661686,0.0329202658555029,FALSE
+"H1650","Pearson.est","PLK inhibitor",0.70612,1.75,0.0226,116,0.189,"GW.843682X, rigosertib, NMS.1286937, volasertib",1.6458915608526,0.723538195826756,TRUE
+"H1650","Pearson.est","potassium channel blocker",-0.3817,-1.02,0.386,1433,0.894,"ibutilide",0.413412695328245,0.0486624812040823,FALSE
+"H1650","Pearson.est","PPAR receptor agonist",-0.70532,-1.86,0.012,1191,0.164,"pterostilbene, clofibrate, fenofibrate, GW.501516",1.92081875395238,0.785156151952302,TRUE
+"H1650","Pearson.est","progesterone receptor agonist",-0.40049,-1.06,0.351,1148,0.857,"norgestrel, levonorgestrel, norethindrone.acetate",0.454692883534176,0.0670191780768018,FALSE
+"H1650","Pearson.est","proteasome inhibitor",0.51239,1.32,0.166,381,0.387,"bortezomib, MG.132, ixazomib, carfilzomib",0.779891911959945,0.412289034981089,FALSE
+"H1650","Pearson.est","protein synthesis inhibitor",0.35454,0.902,0.571,159,0.795,"tedizolid.phosphate, florfenicol, harringtonine, cycloheximide, thiostrepton",0.243363891754152,0.0996328713435297,FALSE
+"H1650","Pearson.est","protein tyrosine kinase inhibitor",-0.30396,-0.798,0.709,1276,0.893,"BMS.599626, rheochrysidin",0.149353764816933,0.0491485411114536,FALSE
+"H1650","Pearson.est","RAF inhibitor",0.54278,1.39,0.148,252,0.365,"sorafenib, dabrafenib, SB.590885, AZ.628",0.829738284605043,0.437707135543525,FALSE
+"H1650","Pearson.est","RET tyrosine kinase inhibitor",0.39165,0.988,0.451,481,0.711,"sorafenib, sunitinib, cabozantinib, regorafenib",0.345823458122039,0.148130399270234,FALSE
+"H1650","Pearson.est","retinoid receptor agonist",-0.28212,-0.721,0.786,1108,0.958,"AM.580, fenretinide, LE.135, adapalene",0.104577453960592,0.0186344909214556,FALSE
+"H1650","Pearson.est","ribonucleotide reductase inhibitor",-0.34231,-0.897,0.559,1310,0.882,"hydroxyurea, clofarabine",0.252588192113577,0.0545314148681803,FALSE
+"H1650","Pearson.est","serotonin receptor agonist",0.671,1.69,0.031,183,0.201,"aripiprazole, pardoprunox, zolmitriptan, ipsapirone",1.50863830616573,0.696803942579511,TRUE
+"H1650","Pearson.est","serotonin receptor antagonist",0.57415,1.47,0.0976,280,0.345,"aripiprazole, ziprasidone, paliperidone, pirenperone, SB.200646",1.01055018233331,0.462180904926726,FALSE
+"H1650","Pearson.est","sodium channel blocker",-0.26034,-0.696,0.819,1198,0.903,"oxcarbazepine, quinidine, cibenzoline",0.0867160982395816,0.0443122496864942,FALSE
+"H1650","Pearson.est","src inhibitor",-0.34261,-0.931,0.519,1023,0.852,"bosutinib, saracatinib, ZM.306416, dasatinib, PP.1",0.284832642151542,0.0695604052332999,FALSE
+"H1650","Pearson.est","sterol demethylase inhibitor",-0.37912,-1.01,0.419,943,0.863,"lanoconazole, posaconazole, terconazole",0.377785977033705,0.0639892042847904,FALSE
+"H1650","Pearson.est","TGF beta receptor inhibitor",0.55827,1.41,0.133,558,0.384,"repsox, SB.431542, LY2109761, D.4476",0.876148359032914,0.415668775632469,FALSE
+"H1650","Pearson.est","thymidylate synthase inhibitor",0.48271,1.24,0.223,267,0.447,"carmofur, trifluridine, capecitabine",0.651695136951839,0.349692476868064,FALSE
+"H1650","Pearson.est","topoisomerase inhibitor",0.25748,0.661,0.851,567,0.92,"topotecan, SN.38, nemorubicin, dexrazoxane, daunorubicin, valrubicin, idarubicin, genz.644282, rubitecan, etoposide.phosphate, fleroxacin, TAS.103, voreloxin",0.0700704399154121,0.0362121726544447,FALSE
+"H1650","Pearson.est","tubulin polymerization inhibitor",0.60463,1.53,0.0724,497,0.308,"fosbretabulin, verubulin, docetaxel, vindesine, vinblastine, albendazole, taltobulin, epothilone.b, BNC105, plinabulin, KX2.391, paclitaxel, combretastatin.A.4, oxibendazole, dolastatin.10, vincristine, podophyllotoxin, fenbendazole, ABT.751, parbendazole, indibulin",1.14026143380285,0.511449283499556,FALSE
+"H1650","Pearson.est","tyrosine kinase inhibitor",0.29543,0.742,0.747,120,0.858,"sorafenib, tivantinib, UNC2250, PP.121",0.126679398184601,0.0665127121512946,FALSE
+"H1650","Pearson.est","VEGFR inhibitor",0.31419,0.784,0.707,286,0.819,"OSI.930, sorafenib, axitinib, KI.8751, dovitinib, nintedanib, semaxanib, tivozanib, ENMD.2076, sunitinib",0.150580586203101,0.0867160982395816,FALSE
+"H1650","Pearson.est","vitamin D receptor agonist",-0.4232,-1.09,0.358,1179,0.986,"doxercalciferol, paricalcitol",0.446116973356126,0.0061230850587888,FALSE
+"HCC95","Pearson.est","EGFR inhibitor",-0.72735,-1.93,0.0103,1177,0.337,"BIBX.1382, pelitinib, WZ.4002, salvianolic.acid.B, ARRY.334543, brigatinib, BIBU.1361, BMS.599626, AEE788, rociletinib, poziotinib, WZ8040, icotinib, BMS.690514, CNX.2006, AZD8931, erlotinib, dacomitinib, WZ.3146, osimertinib, afatinib, canertinib, tucatinib, gefitinib, neratinib, CUDC.101, XL.647, CP.724714, lapatinib",1.98716277529483,0.472370099128661,FALSE
+"HCC95","Pearson.est","Abl kinase inhibitor",0.24134,0.607,0.914,148,0.979,"KW.2449, GZD824",0.0390538042661686,0.00921730819686218,FALSE
+"HCC95","Pearson.est","acetylcholine receptor agonist",0.70826,1.74,0.0166,351,0.203,"tremorine, xanomeline, nefiracetam, oxiracetam",1.77989191195995,0.692503962086787,TRUE
+"HCC95","Pearson.est","acetylcholine receptor antagonist",-0.49272,-1.26,0.22,1343,0.714,"dicycloverine, diphemanil",0.657577319177794,0.146301788223826,FALSE
+"HCC95","Pearson.est","adenosine receptor antagonist",-0.47138,-1.25,0.199,1353,0.67,"PSB.1115, CGS.15943",0.701146923590293,0.173925197299174,FALSE
+"HCC95","Pearson.est","adrenergic receptor agonist",-0.31143,-0.81,0.687,1327,0.812,"buphenine, methyldopa, lidamidine",0.16304326294045,0.0904439707588247,FALSE
+"HCC95","Pearson.est","adrenergic receptor antagonist",-0.32106,-0.842,0.612,1375,0.818,"dihydroergocristine, atenolol......, practolol",0.213248577854439,0.087246696328677,FALSE
+"HCC95","Pearson.est","AKT inhibitor",-0.36201,-0.944,0.492,1112,0.827,"GSK2110183, AT7867, GDC.0068, A.674563, uprosertib",0.30803489723264,0.0824944904474534,FALSE
+"HCC95","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.55548,-1.49,0.0882,1188,0.539,"NVP.TAE684, brigatinib, CEP.37440, AZD3463",1.05453141486818,0.268411234813261,FALSE
+"HCC95","Pearson.est","androgen receptor antagonist",0.34871,0.867,0.625,230,0.932,"flutamide",0.204119982655925,0.0305840876460186,FALSE
+"HCC95","Pearson.est","antioxidant",0.57903,1.41,0.104,494,0.595,"benfotiamine, trolox, mesna, chlorogenic.acid, taurine",0.98296666070122,0.22548303427145,FALSE
+"HCC95","Pearson.est","AP inhibitor",0.38663,0.955,0.476,366,0.846,"idronoxil, birinapant, GDC.0152",0.322393047279507,0.0726296369609765,FALSE
+"HCC95","Pearson.est","ATPase inhibitor",0.29365,0.726,0.782,13,0.957,"k.strophanthidin",0.106793246940152,0.0190880622231565,FALSE
+"HCC95","Pearson.est","Aurora kinase inhibitor",0.31667,0.774,0.716,417,1,"KW.2449, ZM.447439, SNS.314, aurora.a.inhibitor.i, AMG900, MK.5108, PF.03814735, AT.9283, alisertib, MLN.8054",0.145086977692144,0,FALSE
+"HCC95","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.28029,0.687,0.854,485,0.962,"tilmicosin, josamycin, dirithromycin",0.068542129310995,0.0168249279621871,FALSE
+"HCC95","Pearson.est","bacterial DNA gyrase inhibitor",0.52996,1.32,0.162,311,0.702,"nadifloxacin, finafloxacin, norfloxacin, trovafloxacin",0.790484985457369,0.153662887870195,FALSE
+"HCC95","Pearson.est","BCL inhibitor",-0.22274,-0.587,0.942,1180,0.963,"venetoclax, obatoclax",0.0259490972071227,0.0163737128754655,FALSE
+"HCC95","Pearson.est","Bcr.Abl kinase inhibitor",-0.35015,-0.938,0.515,1270,0.801,"dasatinib, metatinib, imatinib",0.288192770958809,0.0963674839157623,FALSE
+"HCC95","Pearson.est","benzodiazepine receptor agonist",0.21607,0.523,0.977,21,0.991,"CGS.20625",0.0101054362812269,0.00392634551472468,FALSE
+"HCC95","Pearson.est","bromodomain inhibitor",0.48228,1.19,0.266,37,0.77,"PFI.1",0.575118363368933,0.113509274827518,FALSE
+"HCC95","Pearson.est","calcium channel blocker",-0.31788,-0.804,0.687,1236,0.795,"mibefradil, tetrandrine, penfluridol",0.16304326294045,0.0996328713435297,FALSE
+"HCC95","Pearson.est","CC chemokine receptor antagonist",0.42502,1.04,0.398,219,0.91,"MK.0812, UNBS.5162",0.400116927926312,0.0409586076789064,FALSE
+"HCC95","Pearson.est","CDK inhibitor",-0.46168,-1.21,0.227,1054,0.634,"aminopurvalanol.a, CR8..R., BMS.265246, JNJ.7706621, PHA.848125, PHA.793887, alvocidib, ribociclib, AT.7519, palbociclib, arcyriaflavin.a, dinaciclib, BMS.387032",0.643974142806877,0.197910742118267,FALSE
+"HCC95","Pearson.est","CHK inhibitor",-0.67205,-1.8,0.0202,1030,0.393,"CHIR.124, LY2603618, AZD7762, LY2606368, SCH.900776, PF.477736",1.69464863055338,0.405607449624573,FALSE
+"HCC95","Pearson.est","cyclooxygenase inhibitor",0.39743,0.967,0.477,117,0.852,"suxibuzone, ketoprofen, AM.404, metoxibutropate, phenylbutazone",0.321481620959886,0.0695604052332999,FALSE
+"HCC95","Pearson.est","cytochrome P450 inhibitor",0.65294,1.62,0.0383,244,0.264,"eplerenone, cobicistat, metyrapone",1.41680122603138,0.578396073130169,FALSE
+"HCC95","Pearson.est","DNA alkylating agent",-0.39787,-1.07,0.344,1206,0.687,"dianhydrogalactitol, mitomycin.c, dacarbazine",0.46344155742847,0.16304326294045,FALSE
+"HCC95","Pearson.est","DNA inhibitor",0.24581,0.606,0.932,428,0.958,"sangivamycin, pibenzimol, metronidazole, valrubicin, nimorazole, tirapazamine",0.0305840876460186,0.0186344909214556,FALSE
+"HCC95","Pearson.est","DNA methyltransferase inhibitor",0.29839,0.737,0.769,288,0.965,"decitabine, RG108",0.114073660198569,0.0154726866562074,FALSE
+"HCC95","Pearson.est","DNA polymerase inhibitor",-0.30783,-0.821,0.653,1364,0.822,"cidofovir",0.185086818724926,0.0851281824599496,FALSE
+"HCC95","Pearson.est","DNA synthesis inhibitor",0.34326,0.846,0.635,97,0.942,"artesunate, nelarabine, CB.10.277",0.197226274708024,0.0259490972071227,FALSE
+"HCC95","Pearson.est","dopamine receptor antagonist",0.40454,0.99,0.442,187,0.872,"nemonapride, paliperidone, raclopride, clebopride",0.354577730650908,0.0594835150674328,FALSE
+"HCC95","Pearson.est","estrogen receptor agonist",-0.46816,-1.22,0.249,1367,0.667,"equol, levonorgestrel",0.603800652904264,0.175874166083451,FALSE
+"HCC95","Pearson.est","estrogen receptor antagonist",0.38704,0.953,0.523,381,0.82,"fulvestrant, raloxifene, danazol, toremifene",0.281498311132726,0.0861861476162833,FALSE
+"HCC95","Pearson.est","FGFR inhibitor",0.31238,0.763,0.745,5,0.975,"MK.2461",0.127843727251707,0.0109953843014632,FALSE
+"HCC95","Pearson.est","FLT3 inhibitor",0.34836,0.842,0.668,54,0.921,"KW.2449, gilteritinib",0.175223537524454,0.0357403698031511,FALSE
+"HCC95","Pearson.est","glucocorticoid receptor agonist",-0.34976,-0.926,0.535,1022,0.788,"prednisolone, desonide, dexamethasone.acetate, deflazacort, halobetasol.propionate, ciclesonide, triamcinolone.acetonide, betamethasone, beclomethasone.dipropionate, fluorometholone, difluprednate, fluticasone.propionate, methylprednisolone, prednisolone.acetate, halcinonide, flumethasone.pivalate, flumethasone",0.271646217978772,0.103473782510445,FALSE
+"HCC95","Pearson.est","glutamate receptor antagonist",0.24351,0.612,0.912,11,0.997,"JNJ.16259685",0.0400051616715838,0.00130484168834428,FALSE
+"HCC95","Pearson.est","glycogen synthase kinase inhibitor",0.5311,1.32,0.173,347,0.702,"kenpaullone, LY2090314, GSK.3.inhibitor.IX",0.761953896871205,0.153662887870195,FALSE
+"HCC95","Pearson.est","growth factor receptor inhibitor",-0.60876,-1.61,0.0551,1293,0.398,"GW.441756, AZD3463",1.25884840114821,0.400116927926312,FALSE
+"HCC95","Pearson.est","HCV inhibitor",0.40707,1,0.436,196,0.885,"mericitabine, narlaprevir",0.360513510731414,0.0530567293021746,FALSE
+"HCC95","Pearson.est","HDAC inhibitor",0.30458,0.761,0.741,478,0.952,"RGFP966, R306465, romidepsin, entinostat, RG2833, panobinostat, AR.42, nexturastat.a, belinostat, JNJ.26481585, mocetinostat",0.130181792020672,0.0213630516155257,FALSE
+"HCC95","Pearson.est","histamine receptor antagonist",0.41016,1.03,0.404,208,0.854,"ICI.162846, BF2.649, famotidine, epinastine, nizatidine",0.393618634889395,0.068542129310995,FALSE
+"HCC95","Pearson.est","HMGCR inhibitor",0.92228,2.24,0,118,0.00185,"mevastatin, pitavastatin, lovastatin, fluvastatin, atorvastatin, simvastatin",Inf,2.73282827159699,TRUE
+"HCC95","Pearson.est","HSP inhibitor",0.73688,1.78,0.00322,172,0.196,"SNX.5422, BIIB021, ganetespib, tanespimycin, XL888, NVP.AUY922, SNX.2112, KW.2478",2.49214412830417,0.707743928643524,TRUE
+"HCC95","Pearson.est","JAK inhibitor",-0.35301,-0.966,0.428,1040,0.821,"TG.101209, filgotinib, TG.101348, CEP.33779, atiprimod, pacritinib, ruxolitinib",0.368556230986828,0.0856568428805592,FALSE
+"HCC95","Pearson.est","KIT inhibitor",-0.33293,-0.898,0.561,1232,0.809,"tandutinib, dasatinib, pazopanib, lenvatinib, imatinib",0.251037138743839,0.0920514783877277,FALSE
+"HCC95","Pearson.est","MDM inhibitor",0.68899,1.7,0.024,427,0.216,"AMG.232, CGM097, serdemetan, RITA",1.61978875828839,0.665546248849069,TRUE
+"HCC95","Pearson.est","MEK inhibitor",0.4747,1.19,0.279,391,0.77,"PD.184352, arctigenin, refametinib, PD.318088, nobiletin, TAK.733, AZD8330, Ro.4987655",0.554395796726402,0.113509274827518,FALSE
+"HCC95","Pearson.est","MET inhibitor",0.77029,1.9,0.00322,278,0.0897,"NVP.BVU972, AMG458, PF.04217903, PHA.665752",2.49214412830417,1.04720755695591,TRUE
+"HCC95","Pearson.est","microtubule inhibitor",0.4118,1.03,0.408,382,0.854,"cytochalasin.b, secnidazole, estramustine.phosphate, cabazitaxel, vinblastine",0.38933983691012,0.068542129310995,FALSE
+"HCC95","Pearson.est","mTOR inhibitor",-0.44389,-1.2,0.245,1007,0.607,"deforolimus, sirolimus, everolimus, XL388, OSI.027, MLN0128, WAY.600, PI.103, PP242, torin.1, PF.05212384, PKI.179, ku.0063794, AZD8055, WYE.354, GDC.0980, WYE.125132",0.610833915635468,0.216811308924742,FALSE
+"HCC95","Pearson.est","NFkB pathway inhibitor",0.49999,1.21,0.226,399,0.824,"BAY.11.7085, parthenolide, BAY.11.7082, tyloxapol",0.645891560852599,0.0840727883028842,FALSE
+"HCC95","Pearson.est","opioid receptor agonist",0.67406,1.65,0.037,348,0.257,"cebranopadol, trimebutine, BW.180C, spiradoline",1.431798275933,0.590066876668705,FALSE
+"HCC95","Pearson.est","p38 MAPK inhibitor",0.31552,0.768,0.719,405,0.995,"TAK.715, VX.702, CMPD.1",0.143271109617117,0.00217691925427455,FALSE
+"HCC95","Pearson.est","PARP inhibitor",0.50912,1.24,0.22,132,0.87,"AG.14361, AZD2461",0.657577319177794,0.0604807473813815,FALSE
+"HCC95","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.20641,-0.55,0.964,1232,0.962,"tandutinib, dasatinib, pazopanib, lenvatinib, imatinib",0.0159229660971692,0.0168249279621871,FALSE
+"HCC95","Pearson.est","phosphatase inhibitor",0.44608,1.11,0.303,334,0.827,"bis.maltolato.oxovanadium.IV., CID.5458317, BVT.948, GSK2830371, alexidine",0.518557371497695,0.0824944904474534,FALSE
+"HCC95","Pearson.est","phosphodiesterase inhibitor",0.46698,1.15,0.305,354,0.822,"GSK256066, avanafil, EMD.53998, zardaverine, anagrelide, YM.976",0.515700160653214,0.0851281824599496,FALSE
+"HCC95","Pearson.est","PI3K inhibitor",-0.43933,-1.14,0.284,1262,0.632,"alpelisib, PF.05212384, PKI.179, BGT226, PI3K.IN.2, taselisib, GDC.0980, idelalisib",0.546681659952962,0.199282921717615,FALSE
+"HCC95","Pearson.est","PLK inhibitor",-0.43648,-1.15,0.285,1098,0.655,"GW.843682X, volasertib, NMS.1286937",0.54515513999149,0.183758700008217,FALSE
+"HCC95","Pearson.est","potassium channel blocker",0.28786,0.69,0.845,231,0.982,"meglitinide, dofetilide",0.0731432910503077,0.00788851221305034,FALSE
+"HCC95","Pearson.est","PPAR receptor agonist",0.45632,1.12,0.326,371,0.85,"S26948, ciprofibrate, clofibrate, fenofibrate",0.486782399932061,0.0705810742857073,FALSE
+"HCC95","Pearson.est","progesterone receptor agonist",0.49207,1.21,0.27,318,0.824,"norethindrone, tanaproget, dienogest, norgestrel, danazol",0.568636235841013,0.0840727883028842,FALSE
+"HCC95","Pearson.est","proteasome inhibitor",-0.26894,-0.716,0.776,387,0.877,"ixazomib, ixazomib.citrate, bortezomib, oprozomib, carfilzomib, ONX.0914, delanzomib, MG.132",0.110138278741812,0.0570004066339595,FALSE
+"HCC95","Pearson.est","protein synthesis inhibitor",0.25891,0.625,0.901,453,1,"florfenicol, azomycin..2.nitroimidazole., mercaptopurine, clindamycin.phosphate, brefeldin.a, puromycin, methacycline, cycloheximide",0.045275209020937,0,FALSE
+"HCC95","Pearson.est","protein tyrosine kinase inhibitor",-0.65889,-1.78,0.0241,1229,0.295,"tyrphostin.A9, NVP.TAE226, BMS.599626, AV.412, CP.724714",1.61798295742513,0.530177984021837,FALSE
+"HCC95","Pearson.est","RAF inhibitor",-0.41051,-1.12,0.296,1208,0.631,"TAK.632, GDC.0879, SB.590885, CEP.32496, AZ.628",0.528708288941061,0.199970640755866,FALSE
+"HCC95","Pearson.est","RET tyrosine kinase inhibitor",-0.28383,-0.752,0.748,409,0.851,"sorafenib, apatinib, cabozantinib, vandetanib, regorafenib, sunitinib",0.126098402135539,0.0700704399154121,FALSE
+"HCC95","Pearson.est","retinoid receptor agonist",-0.52117,-1.37,0.172,1161,0.621,"bexarotene, adarotene, tamibarotene, adapalene, CD.437",0.764471553092451,0.20690839982342,FALSE
+"HCC95","Pearson.est","ribonucleotide reductase inhibitor",0.44705,1.1,0.333,273,0.809,"cytarabine, clofarabine, hydroxyurea, fludarabine, triapine",0.47755576649368,0.0920514783877277,FALSE
+"HCC95","Pearson.est","serotonin receptor antagonist",0.61278,1.53,0.0424,92,0.379,"tropisetron, lerisetron, paliperidone",1.37263414340727,0.421360790031928,FALSE
+"HCC95","Pearson.est","sodium channel blocker",0.19316,0.478,0.991,322,0.986,"A.803467, oxcarbazepine, mexiletine",0.00392634551472468,0.0061230850587888,FALSE
+"HCC95","Pearson.est","src inhibitor",-0.52822,-1.39,0.14,1270,0.66,"dasatinib, PP.1, saracatinib",0.853871964321762,0.180456064458131,FALSE
+"HCC95","Pearson.est","sterol demethylase inhibitor",0.40165,0.972,0.49,86,0.874,"sulconazole",0.309803919971486,0.058488567365597,FALSE
+"HCC95","Pearson.est","TGF beta receptor inhibitor",-0.49906,-1.3,0.179,942,0.699,"SB.525334, repsox, LY2109761, adaprev, SB.431542",0.747146969020107,0.155522824254319,FALSE
+"HCC95","Pearson.est","thymidylate synthase inhibitor",-0.34012,-0.874,0.616,1283,0.822,"carmofur",0.210419287835575,0.0851281824599496,FALSE
+"HCC95","Pearson.est","topoisomerase inhibitor",0.35906,0.889,0.584,493,0.919,"nemorubicin, etoposide, camptothecin, beta.lapachone, valrubicin, doxorubicin, rubitecan, amonafide, fleroxacin, etoposide.phosphate, daunorubicin, voreloxin, teniposide, exatecan.mesylate",0.233587152887601,0.0366844886138887,FALSE
+"HCC95","Pearson.est","tubulin polymerization inhibitor",-0.32468,-0.87,0.605,968,0.797,"fosbretabulin, dolastatin.10, vinorelbine, parbendazole, mebendazole, oxibendazole, plinabulin, taltobulin, ABT.751, CYT.997, fenbendazole",0.218244625347531,0.0985416786038876,FALSE
+"HCC95","Pearson.est","tyrosine kinase inhibitor",-0.37409,-0.99,0.436,1229,0.812,"tyrphostin.A9, NVP.TAE226, dasatinib, BMS.599626, tivantinib, AV.412, CP.724714",0.360513510731414,0.0904439707588247,FALSE
+"HCC95","Pearson.est","VEGFR inhibitor",-0.26801,-0.713,0.805,1276,0.854,"pazopanib, AEE788, lucitanib, SAR131675, BMS.690514, lenvatinib, XL.647",0.0942041196321315,0.068542129310995,FALSE
+"HCC95","Pearson.est","vitamin D receptor agonist",-0.61933,-1.62,0.0483,1247,0.473,"tacalcitol, doxercalciferol, maxacalcitol",1.31605286924849,0.325138859262188,FALSE
+"H1975","Pearson.est","EGFR inhibitor",0.33978,0.889,0.556,315,0.782,"CUDC.101, tucatinib, neratinib, dovitinib, CP.724714, brigatinib, BMS.599626, BMS.690514, lapatinib, ARRY.334543, WZ.4002, AZD8931",0.254925208417942,0.106793246940152,FALSE
+"H1975","Pearson.est","Abl kinase inhibitor",-0.55165,-1.42,0.117,1025,0.513,"tozasertib, ponatinib, bafetinib, GZD824, KW.2449, bosutinib, flumatinib",0.931814138253838,0.289882634888184,FALSE
+"H1975","Pearson.est","acetylcholine receptor agonist",0.33619,0.865,0.582,528,0.776,"oxiracetam, xanomeline, pilocarpine, nefiracetam",0.235077015350112,0.110138278741812,FALSE
+"H1975","Pearson.est","acetylcholine receptor antagonist",-0.30081,-0.772,0.746,917,0.836,"hyoscyamine, dicycloverine, diphemanil, iododexetimide",0.127261172527331,0.0777937225609836,FALSE
+"H1975","Pearson.est","adenosine receptor antagonist",-0.35786,-0.898,0.555,1438,0.734,"theophylline",0.255707016877324,0.134303940083929,FALSE
+"H1975","Pearson.est","adrenergic receptor agonist",-0.44122,-1.11,0.333,1234,0.609,"xylazine, isoetharine, terbutaline, epinephrine, norepinephrine, A61603",0.47755576649368,0.215382707367125,FALSE
+"H1975","Pearson.est","adrenergic receptor antagonist",-0.26637,-0.67,0.837,1190,0.874,"idazoxan, carvedilol, naftidrofuryl, atenolol...., metoprolol",0.07727454200674,0.058488567365597,FALSE
+"H1975","Pearson.est","AKT inhibitor",0.3241,0.838,0.614,577,0.735,"uprosertib, GDC.0068, AZD5363, GSK2110183, CCT128930, AT7867",0.211831628858832,0.133712660915805,FALSE
+"H1975","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.33363,0.86,0.614,165,0.762,"SB.505124, crizotinib, brigatinib",0.211831628858832,0.1180450286604,FALSE
+"H1975","Pearson.est","androgen receptor antagonist",0.32153,0.845,0.623,243,0.744,"RU.58841, nilutamide",0.20551195334083,0.128427064454121,FALSE
+"H1975","Pearson.est","antioxidant",0.45178,1.16,0.274,159,0.768,"trolox",0.562249437179612,0.114638779968488,FALSE
+"H1975","Pearson.est","AP inhibitor",0.33578,0.879,0.575,340,0.775,"embelin, birinapant",0.24033215531037,0.11069829749369,FALSE
+"H1975","Pearson.est","ATPase inhibitor",0.56875,1.48,0.107,300,0.471,"k.strophanthidin, digoxin, thonzonium, omeprazole, NMS.873",0.97061622231479,0.326979092871104,FALSE
+"H1975","Pearson.est","Aurora kinase inhibitor",-0.38383,-0.978,0.462,1020,0.726,"GSK1070916, tozasertib, MK.8745, PF.03814735, AMG900, SNS.314, AT.9283, ZM.447439, alisertib, TAK.901, KW.2449, MK.5108, CYC116",0.335358024443874,0.139063379299906,FALSE
+"H1975","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.28328,0.726,0.79,198,0.803,"azalomycin.b, radezolid",0.102372908709559,0.095284454721319,FALSE
+"H1975","Pearson.est","bacterial DNA gyrase inhibitor",-0.50917,-1.27,0.19,1115,0.525,"sarafloxacin, trovafloxacin, novobiocin, sparfloxacin",0.721246399047171,0.279840696594043,FALSE
+"H1975","Pearson.est","BCL inhibitor",0.39791,1.05,0.392,537,0.697,"venetoclax, obatoclax, oridonin, HA14.1, navitoclax, TW.37",0.406713932979543,0.156767221901991,FALSE
+"H1975","Pearson.est","Bcr.Abl kinase inhibitor",-0.54824,-1.42,0.111,1025,0.513,"tozasertib, ponatinib, bafetinib, GZD824, bosutinib, flumatinib",0.954677021213343,0.289882634888184,FALSE
+"H1975","Pearson.est","benzodiazepine receptor agonist",0.29417,0.769,0.762,10,0.764,"eprinomectin",0.1180450286604,0.11690664142431,FALSE
+"H1975","Pearson.est","bromodomain inhibitor",-0.45247,-1.14,0.285,1163,0.586,"bromosporine, OTX015, PFI.1",0.54515513999149,0.232102383981909,FALSE
+"H1975","Pearson.est","calcium channel blocker",0.61412,1.6,0.066,168,0.507,"tetrandrine, SKF.96365, cinnarazine, efonidipine.monoethanolate, SR.33805",1.18045606445813,0.294992040666664,FALSE
+"H1975","Pearson.est","CC chemokine receptor antagonist",-0.34049,-0.869,0.592,1238,0.734,"UNBS.5162, MK.0812",0.22767829327708,0.134303940083929,FALSE
+"H1975","Pearson.est","CDK inhibitor",0.59565,1.53,0.0877,359,0.43,"R547, AT.7519, indirubin, AZD5438, BMS.387032, TG.02, JNJ.7706621, BMS.265246, indisulam, alvocidib, P276.00, CR8..R., NU6027",1.05700040663396,0.366531544420413,FALSE
+"H1975","Pearson.est","CHK inhibitor",-0.56827,-1.43,0.132,1053,0.633,"LY2603618, CHIR.124, AZD7762, LY2606368",0.87942606879415,0.198596289982645,FALSE
+"H1975","Pearson.est","cyclooxygenase inhibitor",-0.515,-1.32,0.173,1088,0.605,"ramifenazone, pterostilbene, naproxen, indoprofen, FK.3311, sulfasalazine, piroxicam, acetylsalicylsalicylic.acid, metoxibutropate",0.761953896871205,0.218244625347531,FALSE
+"H1975","Pearson.est","cytochrome P450 inhibitor",-0.42145,-1.07,0.349,800,0.596,"itraconazole, morin, metyrapone, clotrimazole, eplerenone, cobicistat",0.45717457304082,0.224753740259764,FALSE
+"H1975","Pearson.est","DNA alkylating agent",-0.29456,-0.753,0.75,928,0.84,"mitomycin.c, melphalan, cisplatin, satraplatin, streptozotocin, cyclophosphamide, dianhydrogalactitol",0.1249387366083,0.0757207139381184,FALSE
+"H1975","Pearson.est","DNA inhibitor",0.40062,1.05,0.381,329,0.697,"busulfan, nimorazole, mechlorethamine, sangivamycin, nithiamide, carmustine, metronidazole",0.419075024324381,0.156767221901991,FALSE
+"H1975","Pearson.est","DNA methyltransferase inhibitor",0.52569,1.4,0.136,196,0.516,"disulfiram, azacitidine, fdcyd",0.866461091629782,0.287350298372789,FALSE
+"H1975","Pearson.est","DNA polymerase inhibitor",0.30209,0.794,0.683,228,0.763,"idoxuridine, cidofovir, menadione",0.165579296318467,0.11747546204512,FALSE
+"H1975","Pearson.est","DNA synthesis inhibitor",-0.50875,-1.25,0.21,1208,0.525,"artesunate, CB.10.277, estramustine.phosphate, altretamine",0.677780705266081,0.279840696594043,FALSE
+"H1975","Pearson.est","dopamine receptor antagonist",0.30873,0.788,0.691,132,0.753,"mesoridazine, ziprasidone, sertindole",0.160521952625802,0.123205023799299,FALSE
+"H1975","Pearson.est","estrogen receptor agonist",-0.59541,-1.5,0.0788,1314,0.656,"estradiol, estradiol.cypionate",1.10347378251044,0.18309616062434,FALSE
+"H1975","Pearson.est","estrogen receptor antagonist",-0.57411,-1.46,0.0833,1216,0.654,"raloxifene, fulvestrant, toremifene",1.07935499859321,0.184422251675733,FALSE
+"H1975","Pearson.est","FGFR inhibitor",0.67617,1.77,0.027,271,0.26,"dovitinib, lenvatinib, nintedanib, erdafitinib, regorafenib",1.56863623584101,0.585026652029182,FALSE
+"H1975","Pearson.est","FLT3 inhibitor",0.3723,0.958,0.486,157,0.757,"sorafenib, ENMD.2076, TG.101348, dovitinib, TG.02",0.313363730737707,0.120904120499927,FALSE
+"H1975","Pearson.est","glucocorticoid receptor agonist",0.57384,1.47,0.101,388,0.443,"hydrocortisone, dexamethasone.acetate, fludroxycortide, difluprednate, desonide, halcinonide, ciclesonide, rimexolone, prednisolone.hemisuccinate, fluocinolone.acetonide, triamcinolone.acetonide, flumethasone, piretanide, methylprednisolone",0.995678626217357,0.35359627377693,FALSE
+"H1975","Pearson.est","glutamate receptor antagonist",-0.5002,-1.27,0.201,1239,0.525,"SIB.1757, JNJ.16259685, kynurenic.acid, MTPG, LY456236",0.696803942579511,0.279840696594043,FALSE
+"H1975","Pearson.est","glycogen synthase kinase inhibitor",-0.28471,-0.72,0.806,1003,0.859,"tideglusib, LY2090314, TWS.119, AZD2858",0.0936649581949093,0.0660068361687577,FALSE
+"H1975","Pearson.est","growth factor receptor inhibitor",0.43045,1.12,0.305,437,0.813,"GSK1838705A, PHA.848125, lestaurtinib",0.515700160653214,0.0899094544059319,FALSE
+"H1975","Pearson.est","HCV inhibitor",0.51201,1.33,0.176,205,0.602,"narlaprevir, embelin, daclatasvir",0.75448733218585,0.220403508742175,FALSE
+"H1975","Pearson.est","HDAC inhibitor",-0.27481,-0.692,0.826,1193,0.871,"M.344, SB.939, RG2833, entinostat, mocetinostat",0.0830199526796178,0.0599818449923368,FALSE
+"H1975","Pearson.est","histamine receptor antagonist",-0.50196,-1.27,0.207,1015,0.525,"terfenadine, nizatidine, zolantidine, ICI.162846, pheniramine, cimetidine, ebastine, lafutidine, tiotidine, BF2.649, chloropyramine",0.684029654543082,0.279840696594043,FALSE
+"H1975","Pearson.est","HMGCR inhibitor",-0.59994,-1.53,0.071,1117,0.948,"fluvastatin, mevastatin, simvastatin, pitavastatin",1.14874165128092,0.0231916626619338,FALSE
+"H1975","Pearson.est","HSP inhibitor",-0.31368,-0.797,0.715,996,0.824,"VER.49009, BIIB021, NVP.AUY922, alvespimycin, ganetespib, SNX.5422",0.145693958198919,0.0840727883028842,FALSE
+"H1975","Pearson.est","JAK inhibitor",0.46562,1.19,0.257,437,0.748,"AZD1480, AZ960, TG.101348, TG.02, filgotinib, TG.101209, atiprimod, baricitinib, ruxolitinib, lestaurtinib",0.590066876668705,0.126098402135539,FALSE
+"H1975","Pearson.est","KIT inhibitor",0.31503,0.818,0.67,447,0.747,"sorafenib, lenvatinib, OSI.930, regorafenib, sunitinib, imatinib, pazopanib, tandutinib",0.173925197299174,0.126679398184601,FALSE
+"H1975","Pearson.est","MDM inhibitor",0.46675,1.2,0.244,97,0.78,"nutlin.3, idasanutlin, CGM097",0.612610173661271,0.10790539730952,FALSE
+"H1975","Pearson.est","MEK inhibitor",0.31762,0.848,0.616,355,0.76,"PD.0325901, cobimetinib, AS.703026, trametinib, MEK162, AZD8330, PD.198306, Ro.4987655",0.210419287835575,0.119186407719209,FALSE
+"H1975","Pearson.est","MET inhibitor",-0.74203,-1.87,0.0138,1179,0.329,"PHA.665752, LY2801653, INC.280, PF.04217903, NVP.BVU972",1.86012091359876,0.482804102050026,FALSE
+"H1975","Pearson.est","microtubule inhibitor",-0.50631,-1.28,0.19,1099,0.636,"D.64131, colchicine, cabazitaxel, estramustine.phosphate",0.721246399047171,0.196542884351586,FALSE
+"H1975","Pearson.est","mTOR inhibitor",0.68659,1.78,0.0176,276,0.328,"voxtalisib, PP242, AZD2014, AZD8055, GSK2126458, XL388, OSI.027, WAY.600, torin.1, ku.0063794, WYE.354, PF.05212384, LY3023414, torin.2, MLN0128, sirolimus",1.75448733218585,0.484126156288321,FALSE
+"H1975","Pearson.est","NFkB pathway inhibitor",-0.37448,-0.96,0.484,1396,0.703,"BAY.11.7082, BAY.11.7085",0.315154638355588,0.153044674980176,FALSE
+"H1975","Pearson.est","opioid receptor agonist",0.41915,1.06,0.369,226,0.74,"salvinorin.a, trimebutine",0.43297363384094,0.130768280269024,FALSE
+"H1975","Pearson.est","p38 MAPK inhibitor",0.41876,1.11,0.309,225,0.747,"skepinone.l, SB.242235, talmapimod",0.510041520575165,0.126679398184601,FALSE
+"H1975","Pearson.est","PARP inhibitor",-0.26019,-0.661,0.875,1195,0.861,"E7449, niraparib",0.0579919469776868,0.0649968485463452,FALSE
+"H1975","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.39917,1.03,0.416,447,0.705,"sorafenib, dovitinib, lenvatinib, crenolanib, nintedanib, regorafenib, sunitinib, linifanib, imatinib, axitinib, pazopanib, tandutinib",0.380906669373257,0.151810883008601,FALSE
+"H1975","Pearson.est","phosphatase inhibitor",-0.34817,-0.888,0.57,1292,0.725,"BVT.948, bis.maltolato.oxovanadium.IV.",0.244125144327509,0.139661993429006,FALSE
+"H1975","Pearson.est","phosphodiesterase inhibitor",-0.36672,-0.924,0.518,1192,0.739,"enoximone, EMD.53998, GSK256066, trequinsin",0.285670240254767,0.131355561605174,FALSE
+"H1975","Pearson.est","PI3K inhibitor",0.51297,1.3,0.178,260,0.618,"CH5132799, voxtalisib, GSK2126458, alpelisib, CUDC.907, BGT226, PI3K.IN.2, PF.05212384, LY3023414, GDC.0941, buparlisib",0.749579997691106,0.209011524911184,FALSE
+"H1975","Pearson.est","PLK inhibitor",-0.60109,-1.5,0.0799,1374,0.656,"BI.2536, GSK461364",1.09745322068601,0.18309616062434,FALSE
+"H1975","Pearson.est","potassium channel blocker",0.38532,0.982,0.447,36,0.739,"ML133",0.349692476868064,0.131355561605174,FALSE
+"H1975","Pearson.est","PPAR receptor agonist",-0.42609,-1.08,0.356,1101,0.606,"pterostilbene, GW.501516, fenofibrate",0.448550002027125,0.217527375833714,FALSE
+"H1975","Pearson.est","progesterone receptor agonist",-0.42607,-1.08,0.351,1172,0.606,"nomegestrol.acetate, dienogest, norethindrone.acetate",0.454692883534176,0.217527375833714,FALSE
+"H1975","Pearson.est","proteasome inhibitor",-0.38054,-0.965,0.486,905,0.721,"carfilzomib, oprozomib, ixazomib.citrate, delanzomib, ONX.0914",0.313363730737707,0.142064735280571,FALSE
+"H1975","Pearson.est","protein synthesis inhibitor",0.35735,0.946,0.502,394,0.754,"tedizolid.phosphate, florfenicol, chloramphenicol.palmitate, bruceantin, harringtonine, methacycline, brefeldin.a, cycloheximide, thiostrepton, clofoctol, azomycin..2.nitroimidazole.",0.299296282854981,0.122628654130226,FALSE
+"H1975","Pearson.est","protein tyrosine kinase inhibitor",0.39744,1.02,0.401,209,0.695,"mubritinib, CP.724714, BMS.599626",0.396855627379818,0.158015195409886,FALSE
+"H1975","Pearson.est","RAF inhibitor",0.43502,1.11,0.327,278,0.747,"sorafenib, SB.590885, dabrafenib, regorafenib, RAF265",0.485452247339714,0.126679398184601,FALSE
+"H1975","Pearson.est","RET tyrosine kinase inhibitor",0.59744,1.56,0.0778,343,0.506,"sorafenib, regorafenib, apatinib, sunitinib",1.10902040301031,0.295849483160201,FALSE
+"H1975","Pearson.est","retinoid receptor agonist",0.36177,0.909,0.541,5,0.771,"adarotene",0.266802734893431,0.112945621949043,FALSE
+"H1975","Pearson.est","ribonucleotide reductase inhibitor",-0.5592,-1.41,0.14,1145,0.481,"triapine, hydroxyurea, LY2334737, gemcitabine, cladribine, fludarabine, clofarabine",0.853871964321762,0.317854923626168,FALSE
+"H1975","Pearson.est","serotonin receptor agonist",0.84011,2.2,0,195,0.0183,"aripiprazole, ipsapirone, NAN.190, zolmitriptan, pardoprunox",Inf,1.73754891026957,TRUE
+"H1975","Pearson.est","serotonin receptor antagonist",0.60067,1.54,0.0762,132,0.472,"aripiprazole, ziprasidone, SB.200646, sertindole",1.1180450286604,0.326058001365912,FALSE
+"H1975","Pearson.est","sodium channel blocker",-0.35182,-0.899,0.567,969,0.757,"benzethonium, mepivacaine, A.803467, cibenzoline, quinidine, oxcarbazepine",0.246416941107093,0.120904120499927,FALSE
+"H1975","Pearson.est","src inhibitor",-0.45592,-1.16,0.297,864,0.583,"dasatinib, KX2.391, masitinib, PP.1, PP.2, bosutinib",0.527243550682788,0.234331445240986,FALSE
+"H1975","Pearson.est","sterol demethylase inhibitor",0.36098,0.924,0.534,187,0.768,"posaconazole, sulconazole",0.272458742971444,0.114638779968488,FALSE
+"H1975","Pearson.est","TGF beta receptor inhibitor",0.72132,1.85,0.00839,348,0.317,"SB.525334, adaprev, SB.431542, repsox",2.0762380391713,0.498940737782249,FALSE
+"H1975","Pearson.est","thymidylate synthase inhibitor",-0.48086,-1.22,0.239,1433,0.514,"doxifluridine",0.621602099051862,0.289036881004724,FALSE
+"H1975","Pearson.est","topoisomerase inhibitor",-0.7243,-1.85,0.0133,1200,0.191,"doxorubicin, epirubicin, amsacrine, etoposide.phosphate, TAS.103, amonafide, voreloxin, mitoxantrone, rubitecan, daunorubicin, teniposide, genz.644282, licochalcone.a, irinotecan, etoposide, exatecan.mesylate",1.87614835903291,0.718966632752272,TRUE
+"H1975","Pearson.est","tubulin polymerization inhibitor",-0.48046,-1.24,0.229,1082,0.51,"dolastatin.10, combretastatin.A.4, docetaxel, epothilone.b, paclitaxel, parbendazole, CYT.997, oxibendazole, fenbendazole, nocodazole, BNC105, epothilone.d",0.640164517660112,0.292429823902064,FALSE
+"H1975","Pearson.est","tyrosine kinase inhibitor",0.23099,0.601,0.916,382,0.921,"sorafenib, mubritinib, CP.724714, BMS.599626, regorafenib, apatinib, sunitinib, tivantinib",0.0381045263321496,0.0357403698031511,FALSE
+"H1975","Pearson.est","VEGFR inhibitor",0.4226,1.1,0.334,532,0.693,"sorafenib, ENMD.2076, dovitinib, lenvatinib, OSI.930, nintedanib, tivozanib, BMS.690514, regorafenib, RAF265, sunitinib, linifanib, AEE788, semaxanib, axitinib, pazopanib, motesanib, TG.100572, foretinib, golvatinib, cediranib",0.476253533188435,0.159266765388193,FALSE
+"H1975","Pearson.est","vitamin D receptor agonist",0.42613,1.1,0.324,316,0.693,"maxacalcitol, tacalcitol, ercalcitriol, alfacalcidol",0.489454989793388,0.159266765388193,FALSE
+"H1648","Pearson.est","EGFR inhibitor",-0.70678,-1.86,0.0106,1278,0.27,"rociletinib, AST.1306, PD.168393, lapatinib, OSI.420, BMS.690514, CP.724714, tyrphostin.AG.1478, vandetanib, BIBU.1361, BIBX.1382, PD.153035, neratinib, XL.647, osimertinib, poziotinib, AZD8931, afatinib, canertinib, pelitinib, dacomitinib, icotinib, gefitinib, erlotinib, WZ8040",1.97469413473523,0.568636235841013,FALSE
+"H1648","Pearson.est","Abl kinase inhibitor",-0.14136,-0.381,1,203,0.999,"flumatinib, nilotinib, GZD824, KW.2449, tozasertib, metatinib, ponatinib, bafetinib, dasatinib, ZM.306416, bosutinib, imatinib",0,0.000434511774017692,FALSE
+"H1648","Pearson.est","acetylcholine receptor agonist",0.77136,1.96,0.00321,223,0.0484,"tremorine, xanomeline, oxiracetam, pilocarpine",2.49349496759513,1.31515463835559,TRUE
+"H1648","Pearson.est","acetylcholine receptor antagonist",-0.5334,-1.47,0.104,1135,0.764,"diphemanil, darifenacin, dicycloverine",0.98296666070122,0.11690664142431,FALSE
+"H1648","Pearson.est","adenosine receptor antagonist",-0.38832,-1.07,0.36,1073,1,"SCH.58261, PSB.1115, theophylline, MRS.1220, CGS.15943",0.443697499232713,0,FALSE
+"H1648","Pearson.est","adrenergic receptor agonist",-0.49783,-1.35,0.155,1040,0.915,"oxymetazoline, xylazine, terbutaline, metaraminol, clenbuterol, lidamidine, isoetharine, A61603, methyldopa",0.809668301829709,0.0385789059335517,FALSE
+"H1648","Pearson.est","adrenergic receptor antagonist",-0.2135,-0.584,0.916,1048,1,"RS.17053, atenolol......, practolol, levobunolol, metoprolol, atenolol...., dronedarone",0.0381045263321496,0,FALSE
+"H1648","Pearson.est","AKT inhibitor",-0.38786,-1.05,0.361,1175,1,"CCT128930, A.674563, uprosertib, triciribine",0.442492798094342,0,FALSE
+"H1648","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.25046,0.64,0.869,362,0.978,"DMH1, alectinib, SB.505124, crizotinib",0.0609802235513335,0.00966114521239857,FALSE
+"H1648","Pearson.est","androgen receptor antagonist",-0.49493,-1.33,0.135,1337,0.811,"cyproterone.acetate, enzalutamide",0.869666231504994,0.090979145788844,FALSE
+"H1648","Pearson.est","antioxidant",0.48825,1.22,0.248,44,0.576,"trolox",0.605548319173784,0.239577516576788,FALSE
+"H1648","Pearson.est","AP inhibitor",0.60089,1.5,0.081,8,0.501,"idronoxil",1.09151498112135,0.300162274132754,FALSE
+"H1648","Pearson.est","ATPase inhibitor",0.50933,1.27,0.192,489,0.662,"k.strophanthidin, oligomycin.a, evodiamine, digoxin, ouabain, digitoxigenin, thonzonium, NMS.873",0.71669877129645,0.1791420105603,FALSE
+"H1648","Pearson.est","Aurora kinase inhibitor",0.43411,1.1,0.349,639,0.677,"barasertib, AMG900, CCT137690, danusertib, SNS.314, MK.5108, PHA.680632, alisertib, AT.9283, GSK1070916, KW.2449, PF.03814735, ENMD.2076, barasertib.HQPA, ZM.447439, hesperadin, tozasertib, MK.8745, CCT129202",0.45717457304082,0.169411331314856,FALSE
+"H1648","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.42972,1.1,0.37,277,0.677,"valnemulin, radezolid",0.431798275933005,0.169411331314856,FALSE
+"H1648","Pearson.est","bacterial DNA gyrase inhibitor",-0.29091,-0.81,0.663,1266,1,"trovafloxacin, lomefloxacin",0.178486471595227,0,FALSE
+"H1648","Pearson.est","BCL inhibitor",0.23801,0.594,0.922,603,1,"TW.37, ABT.737, gossypol, navitoclax",0.0352690789463706,0,FALSE
+"H1648","Pearson.est","Bcr.Abl kinase inhibitor",0.20481,0.512,0.982,369,0.991,"flumatinib, nilotinib, GZD824",0.00788851221305034,0.00392634551472468,FALSE
+"H1648","Pearson.est","benzodiazepine receptor agonist",-0.27555,-0.751,0.757,1161,1,"zaleplon, bentazepam, gamma.aminobutyric.acid, lorazepam",0.120904120499927,0,FALSE
+"H1648","Pearson.est","bromodomain inhibitor",0.48155,1.22,0.224,479,0.576,"PFI.1, bromosporine, I.BET.762, I.BET151",0.649751981665837,0.239577516576788,FALSE
+"H1648","Pearson.est","calcium channel blocker",0.2949,0.752,0.759,17,0.895,"carboxyamidotriazole",0.11975822410452,0.048176964684088,FALSE
+"H1648","Pearson.est","CC chemokine receptor antagonist",0.48413,1.24,0.223,582,0.656,"UNBS.5162, ZK811752, SB.225002, MK.0812, PF.04136309",0.651695136951839,0.18309616062434,FALSE
+"H1648","Pearson.est","CDK inhibitor",-0.27611,-0.757,0.714,1160,1,"CR8..R., TG.02, dinaciclib, alvocidib, BMS.387032, P276.00, arcyriaflavin.a, indirubin",0.146301788223826,0,FALSE
+"H1648","Pearson.est","CHK inhibitor",-0.70877,-1.93,0.005,1116,0.363,"AZD7762, LY2603618, LY2606368, CHIR.124, SCH.900776",2.30102999566398,0.440093374963888,FALSE
+"H1648","Pearson.est","cyclooxygenase inhibitor",-0.25091,-0.702,0.828,1305,1,"indoprofen, tryptanthrin, naproxen, FK.3311",0.0819696632151199,0,FALSE
+"H1648","Pearson.est","cytochrome P450 inhibitor",0.30854,0.774,0.702,283,0.902,"metyrapone, eplerenone",0.153662887870195,0.0447934624580583,FALSE
+"H1648","Pearson.est","DNA alkylating agent",-0.30934,-0.855,0.572,1193,1,"ifosfamide, satraplatin, cisplatin, dacarbazine",0.242603971206976,0,FALSE
+"H1648","Pearson.est","DNA inhibitor",0.35842,0.923,0.554,417,0.759,"valrubicin, teroxirone, tirapazamine, metronidazole, chlorambucil, oxaliplatin, primaquine, bendamustine, carboplatin",0.25649023527157,0.11975822410452,FALSE
+"H1648","Pearson.est","DNA methyltransferase inhibitor",0.56762,1.41,0.116,201,0.51,"decitabine, disulfiram, RG108",0.935542010773082,0.292429823902064,FALSE
+"H1648","Pearson.est","DNA polymerase inhibitor",-0.26494,-0.728,0.82,1021,1,"cidofovir, cephalomannine, menadione, famciclovir",0.0861861476162833,0,FALSE
+"H1648","Pearson.est","DNA synthesis inhibitor",0.38339,0.972,0.478,83,0.731,"azodicarbonamide, artesunate, anisomycin",0.320572103387881,0.13608262304214,FALSE
+"H1648","Pearson.est","dopamine receptor antagonist",0.38747,0.983,0.476,61,0.733,"thioproperazine, paliperidone, raclopride",0.322393047279507,0.134896025358872,FALSE
+"H1648","Pearson.est","estrogen receptor agonist",0.42543,1.07,0.381,200,0.662,"ethinyl.estradiol, estrone",0.419075024324381,0.1791420105603,FALSE
+"H1648","Pearson.est","estrogen receptor antagonist",0.42506,1.07,0.377,739,0.662,"raloxifene, danazol, fulvestrant, clomifene, toremifene",0.423658649794207,0.1791420105603,FALSE
+"H1648","Pearson.est","FGFR inhibitor",0.48643,1.24,0.222,122,0.656,"regorafenib, dovitinib, nintedanib",0.653647025549361,0.18309616062434,FALSE
+"H1648","Pearson.est","FLT3 inhibitor",0.45089,1.12,0.321,169,0.691,"sorafenib, TG.101348, dovitinib, tyrphostin.AG.1296",0.493494967595128,0.160521952625802,FALSE
+"H1648","Pearson.est","glucocorticoid receptor agonist",0.27329,0.697,0.818,531,0.931,"prednisolone.hemisuccinate, fluticasone.propionate, triamcinolone, beclomethasone.dipropionate, rimexolone, dexamethasone.acetate, prednisolone, deflazacort, ciclesonide, methylprednisolone",0.087246696328677,0.0310503190186574,FALSE
+"H1648","Pearson.est","glutamate receptor antagonist",-0.2706,-0.757,0.743,1059,1,"JNJ.16259685, CGP.37849, LY456236, SIB.1757, CPP, kynurenic.acid, diazooxonorleucine",0.129011186239425,0,FALSE
+"H1648","Pearson.est","glycogen synthase kinase inhibitor",-0.3309,-0.886,0.576,1320,1,"GSK.3.inhibitor.IX, indirubin",0.239577516576788,0,FALSE
+"H1648","Pearson.est","growth factor receptor inhibitor",0.5774,1.46,0.0898,318,0.544,"danusertib, PHA.848125, GSK1838705A",1.0467236633327,0.26440110030182,FALSE
+"H1648","Pearson.est","HCV inhibitor",0.57963,1.44,0.11,72,0.536,"narlaprevir, mericitabine",0.958607314841775,0.27083521030723,FALSE
+"H1648","Pearson.est","HDAC inhibitor",-0.31742,-0.83,0.604,1158,1,"M.344, nexturastat.a, SB.939, romidepsin, mocetinostat, tacedinaline, JNJ.26481585",0.218963061378868,0,FALSE
+"H1648","Pearson.est","histamine receptor antagonist",-0.28731,-0.778,0.708,1447,1,"chloropyramine",0.149966742310231,0,FALSE
+"H1648","Pearson.est","HMGCR inhibitor",0.78985,1.99,0.00162,254,0.0535,"atorvastatin, fluvastatin, pitavastatin, lovastatin, mevastatin",2.79048498545737,1.27164621797877,TRUE
+"H1648","Pearson.est","HSP inhibitor",0.48607,1.23,0.245,377,0.612,"SNX.2112, NVP.AUY922, BIIB021, ganetespib, PU.H71, NMS.E973, tanespimycin",0.610833915635468,0.213248577854439,FALSE
+"H1648","Pearson.est","JAK inhibitor",0.31079,0.787,0.719,71,0.903,"TG.101348, AZD1480, AZ960",0.143271109617117,0.0443122496864942,FALSE
+"H1648","Pearson.est","KIT inhibitor",0.46892,1.18,0.269,41,0.598,"sorafenib, masitinib, regorafenib",0.570247719997592,0.223298816011589,FALSE
+"H1648","Pearson.est","MDM inhibitor",0.41792,1.05,0.382,450,0.655,"AMG.232, idasanutlin, nutlin.3, CGM097",0.417936637088291,0.183758700008217,FALSE
+"H1648","Pearson.est","MEK inhibitor",-0.2241,-0.591,0.915,1446,1,"BIX.02188",0.0385789059335517,0,FALSE
+"H1648","Pearson.est","MET inhibitor",0.30164,0.768,0.728,94,0.891,"LY2801653",0.137868620686963,0.0501222959631252,FALSE
+"H1648","Pearson.est","microtubule inhibitor",0.56219,1.43,0.118,321,0.511,"D.64131, cabazitaxel, secnidazole, vinblastine, podophyllotoxin, vinflunine",0.928117992693875,0.291579099865287,FALSE
+"H1648","Pearson.est","mTOR inhibitor",0.18397,0.464,0.981,133,0.988,"ku.0063794, voxtalisib, AZD2014",0.0083309926200515,0.00524305541237188,FALSE
+"H1648","Pearson.est","NFkB pathway inhibitor",-0.30433,-0.819,0.648,1356,1,"bindarit, IKK.2.inhibitor.V",0.188424994129407,0,FALSE
+"H1648","Pearson.est","opioid receptor agonist",0.61952,1.58,0.0546,485,0.44,"trimebutine, salvinorin.a, cebranopadol, spiradoline",1.26280735729526,0.356547323513813,FALSE
+"H1648","Pearson.est","p38 MAPK inhibitor",-0.3817,-1.02,0.379,1122,1,"TAK.715, CMPD.1, SB.239063",0.421360790031928,0,FALSE
+"H1648","Pearson.est","PARP inhibitor",0.50985,1.28,0.202,353,0.682,"niraparib, olaparib, talazoparib, AZD2461",0.694648630553376,0.166215625343521,FALSE
+"H1648","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.48121,1.23,0.227,274,0.612,"sorafenib, masitinib, regorafenib, dovitinib, nintedanib, axitinib, CP.673451, crenolanib, linifanib",0.643974142806877,0.213248577854439,FALSE
+"H1648","Pearson.est","phosphatase inhibitor",-0.21608,-0.583,0.919,1423,1,"mycophenolate.mofetil",0.0366844886138887,0,FALSE
+"H1648","Pearson.est","phosphodiesterase inhibitor",-0.26269,-0.699,0.811,1165,0.982,"zardaverine, GSK256066, cilostamide",0.090979145788844,0.00788851221305034,FALSE
+"H1648","Pearson.est","PI3K inhibitor",0.21896,0.551,0.953,137,0.99,"ZSTK.474, voxtalisib, GDC.0941",0.0209070993616736,0.00436480540245009,FALSE
+"H1648","Pearson.est","PLK inhibitor",0.85982,2.22,0,209,0.00412,"volasertib, NMS.1286937, BI.2536, GW.843682X, GSK461364, rigosertib, HMN.214",Inf,2.38510278396687,TRUE
+"H1648","Pearson.est","potassium channel blocker",0.32242,0.814,0.694,253,0.881,"ML133, mepivacaine",0.158640529545145,0.0550240915879521,FALSE
+"H1648","Pearson.est","PPAR receptor agonist",-0.36691,-0.999,0.44,1083,1,"pterostilbene, GW.501516, S26948, oleoylethanolamide, clofibrate",0.356547323513813,0,FALSE
+"H1648","Pearson.est","progesterone receptor agonist",0.34053,0.859,0.615,503,0.85,"norethindrone, tanaproget, melengestrol.acetate, danazol, nomegestrol.acetate, norgestrel",0.211124884224583,0.0705810742857073,FALSE
+"H1648","Pearson.est","proteasome inhibitor",-0.17014,-0.456,0.989,245,1,"delanzomib, ixazomib, ONX.0914, bortezomib, oprozomib, MG.132, carfilzomib, ixazomib.citrate",0.0048037084028206,0,FALSE
+"H1648","Pearson.est","protein synthesis inhibitor",0.47027,1.21,0.235,382,0.567,"anguidine, thiostrepton, cycloheximide, mercaptopurine, harringtonine, bruceantin, methacycline, homoharringtonine",0.628932137728264,0.246416941107093,FALSE
+"H1648","Pearson.est","protein tyrosine kinase inhibitor",0.37731,0.956,0.503,6,0.739,"mubritinib",0.298432014944073,0.131355561605174,FALSE
+"H1648","Pearson.est","RAF inhibitor",0.42166,1.05,0.409,41,0.655,"sorafenib, regorafenib",0.388276691992658,0.183758700008217,FALSE
+"H1648","Pearson.est","RET tyrosine kinase inhibitor",0.62093,1.58,0.0447,41,0.44,"sorafenib, regorafenib",1.34969247686806,0.356547323513813,FALSE
+"H1648","Pearson.est","retinoid receptor agonist",-0.41621,-1.14,0.28,1308,1,"adapalene, adarotene, CD.437",0.552841968657781,0,FALSE
+"H1648","Pearson.est","ribonucleotide reductase inhibitor",0.61545,1.54,0.0696,513,0.47,"cladribine, triapine, fludarabine.phosphate, cytarabine, clofarabine, pentostatin, fludarabine, gemcitabine",1.15739076038944,0.327902142064283,FALSE
+"H1648","Pearson.est","serotonin receptor agonist",0.32828,0.84,0.664,436,0.86,"zolmitriptan, SR.57227A, pardoprunox",0.177831920631982,0.0655015487564323,FALSE
+"H1648","Pearson.est","serotonin receptor antagonist",0.41142,1.01,0.445,33,0.704,"SB.200646, paliperidone",0.351639989019068,0.152427340857888,FALSE
+"H1648","Pearson.est","sodium channel blocker",-0.3497,-0.957,0.463,1352,1,"benzethonium, lappaconite",0.334419008982047,0,FALSE
+"H1648","Pearson.est","src inhibitor",-0.43688,-1.22,0.241,1388,0.987,"PP.1, saracatinib, PP.2",0.617982957425132,0.00568284733036327,FALSE
+"H1648","Pearson.est","sterol demethylase inhibitor",0.51841,1.32,0.151,490,0.629,"lanoconazole, chlormidazole, sulconazole, ketoconazole, posaconazole",0.821023052706831,0.201349354554731,FALSE
+"H1648","Pearson.est","TGF beta receptor inhibitor",0.42659,1.07,0.378,126,0.662,"adaprev",0.422508200162775,0.1791420105603,FALSE
+"H1648","Pearson.est","thymidylate synthase inhibitor",0.22798,0.576,0.924,660,0.993,"trifluridine, capecitabine, carmofur, raltitrexed, ftorafur",0.0343280287798933,0.00305075150461883,FALSE
+"H1648","Pearson.est","topoisomerase inhibitor",0.68149,1.71,0.0224,248,0.292,"mitoxantrone, idarubicin, TAS.103, voreloxin, etoposide.phosphate, valrubicin, amonafide, amsacrine, daunorubicin, nemorubicin, teniposide, doxorubicin, SN.38, topotecan",1.64975198166584,0.534617148551582,FALSE
+"H1648","Pearson.est","tubulin polymerization inhibitor",0.55276,1.38,0.129,439,0.535,"docetaxel, epothilone.b, verubulin, vindesine, taltobulin, mebendazole, vinblastine, dolastatin.10, podophyllotoxin, BNC105, KX2.391, CYT.997, flubendazole, vincristine, plinabulin, fosbretabulin, combretastatin.A.4",0.889410289700751,0.271646217978772,FALSE
+"H1648","Pearson.est","tyrosine kinase inhibitor",0.36606,0.926,0.535,145,0.774,"mubritinib, sorafenib, regorafenib, hypericin",0.271646217978772,0.111259039317107,FALSE
+"H1648","Pearson.est","VEGFR inhibitor",0.28211,0.713,0.806,151,0.929,"sorafenib, regorafenib, tivozanib, dovitinib, nintedanib, foretinib, axitinib",0.0936649581949093,0.0319842860063582,FALSE
+"H1648","Pearson.est","vitamin D receptor agonist",-0.62747,-1.67,0.0259,1331,0.472,"calcitriol, maxacalcitol, paricalcitol",1.58670023591875,0.326058001365912,FALSE
+"H2126","Pearson.est","EGFR inhibitor",-0.55917,-1.43,0.11,1052,0.564,"AZD8931, dacomitinib, canertinib, tucatinib, TAK.285, rociletinib, osimertinib, OSI.420, pelitinib, poziotinib, BIBX.1382, afatinib, XL.647, WZ.3146, tyrphostin.AG.1478, AEE788, gefitinib, neratinib, PD.168393, BMS.599626, vandetanib, icotinib, GW.583340, AST.1306, BIBU.1361, WZ8040, CP.724714, erlotinib, PD.153035",0.958607314841775,0.248720896016658,FALSE
+"H2126","Pearson.est","Abl kinase inhibitor",0.25223,0.668,0.856,354,0.945,"ponatinib, KW.2449, nilotinib, GZD824, flumatinib",0.0675262353228468,0.0245681914907371,FALSE
+"H2126","Pearson.est","acetylcholine receptor agonist",0.57584,1.57,0.0615,57,0.36,"tremorine, xanomeline",1.21112488422458,0.443697499232713,FALSE
+"H2126","Pearson.est","acetylcholine receptor antagonist",-0.72428,-1.81,0.00862,1297,0.174,"dicycloverine, darifenacin, diphemanil",2.06449273417529,0.7594507517174,TRUE
+"H2126","Pearson.est","adenosine receptor antagonist",-0.7338,-1.82,0.00836,1141,0.48,"theophylline, istradefylline, SCH.58261, MRS.1220, CGS.15943",2.07779372256098,0.318758762624413,FALSE
+"H2126","Pearson.est","adrenergic receptor agonist",-0.43238,-1.08,0.394,1080,0.742,"lidamidine, isoxsuprine, metaraminol, isoetharine, xylazine, A61603",0.404503778174426,0.129596094720973,FALSE
+"H2126","Pearson.est","adrenergic receptor antagonist",-0.33477,-0.843,0.633,982,0.934,"idazoxan, prazosin, metoprolol, imiloxan, atenolol...., naftidrofuryl, pindolol, dronedarone",0.198596289982645,0.0296531237699066,FALSE
+"H2126","Pearson.est","AKT inhibitor",-0.26764,-0.68,0.822,1258,0.932,"palomid.529, A.674563",0.0851281824599496,0.0305840876460186,FALSE
+"H2126","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.34399,0.909,0.554,27,0.757,"DMH1, alectinib",0.25649023527157,0.120904120499927,FALSE
+"H2126","Pearson.est","androgen receptor antagonist",-0.67637,-1.67,0.0317,1175,0.272,"enzalutamide, flutamide, cyproterone.acetate",1.49894073778225,0.565431095965801,FALSE
+"H2126","Pearson.est","antioxidant",-0.31797,-0.797,0.69,1324,0.954,"taurine",0.161150909262745,0.0204516252959049,FALSE
+"H2126","Pearson.est","AP inhibitor",-0.46295,-1.14,0.298,1290,0.736,"birinapant, tanshinone.i",0.525783735923745,0.133122185662501,FALSE
+"H2126","Pearson.est","ATPase inhibitor",0.61586,1.65,0.0469,260,0.415,"ouabain, k.strophanthidin, digitoxigenin, omeprazole, oligomycin.a, NMS.873, evodiamine, thonzonium",1.32882715728492,0.381951903287907,FALSE
+"H2126","Pearson.est","Aurora kinase inhibitor",0.31416,0.85,0.642,480,0.789,"CCT137690, CCT129202, KW.2449, barasertib, ENMD.2076, aurora.a.inhibitor.i, AMG900, GSK1070916, alisertib, SNS.314, MK.8745, PF.03814735, barasertib.HQPA",0.192464971931147,0.10292299679058,FALSE
+"H2126","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.19853,0.52,0.981,298,0.972,"valnemulin, radezolid",0.0083309926200515,0.0123337350737254,FALSE
+"H2126","Pearson.est","bacterial DNA gyrase inhibitor",0.3641,1.01,0.418,67,0.676,"novobiocin, sparfloxacin",0.378823718224965,0.170053304058364,FALSE
+"H2126","Pearson.est","BCL inhibitor",0.30417,0.824,0.661,155,0.809,"navitoclax, ABT.737",0.17979854051436,0.0920514783877277,FALSE
+"H2126","Pearson.est","Bcr.Abl kinase inhibitor",0.19637,0.53,0.966,354,0.991,"ponatinib, nilotinib, GZD824, flumatinib",0.0150228735845067,0.00392634551472468,FALSE
+"H2126","Pearson.est","benzodiazepine receptor agonist",-0.31008,-0.792,0.683,989,0.931,"CGS.20625, indiplon, temazepam, gamma.aminobutyric.acid, lorazepam",0.165579296318467,0.0310503190186574,FALSE
+"H2126","Pearson.est","bromodomain inhibitor",0.68352,1.8,0.02,424,0.472,"I.BET151, PFI.1, I.BET.762, bromosporine",1.69897000433602,0.326058001365912,FALSE
+"H2126","Pearson.est","calcium channel blocker",-0.33728,-0.848,0.631,1383,0.958,"mibefradil, SKF.96365",0.199970640755866,0.0186344909214556,FALSE
+"H2126","Pearson.est","CC chemokine receptor antagonist",0.60818,1.57,0.0884,231,0.36,"ZK811752, UNBS.5162, SB.225002",1.05354773498693,0.443697499232713,FALSE
+"H2126","Pearson.est","CDK inhibitor",-0.35484,-0.901,0.535,984,0.926,"NU6027, JNJ.7706621, kenpaullone, TG.02, alvocidib, dinaciclib, BMS.387032, CR8..R., indirubin, arcyriaflavin.a",0.271646217978772,0.0333890133180656,FALSE
+"H2126","Pearson.est","CHK inhibitor",-0.61936,-1.59,0.0439,1094,0.359,"LY2603618, SCH.900776, AZD7762, LY2606368, CHIR.124",1.35753547975788,0.444905551421681,FALSE
+"H2126","Pearson.est","cyclooxygenase inhibitor",-0.35878,-0.911,0.55,1287,0.943,"phenylbutazone, naproxen, FR.122047, FK.3311",0.259637310505756,0.0254883072626717,FALSE
+"H2126","Pearson.est","cytochrome P450 inhibitor",-0.27412,-0.688,0.815,395,0.947,"cobicistat, PF.4981517, metyrapone, clotrimazole, eplerenone, itraconazole, morin",0.0888423912600234,0.0236500209967266,FALSE
+"H2126","Pearson.est","DNA alkylating agent",-0.25448,-0.63,0.889,1152,0.914,"streptozotocin, satraplatin, cisplatin, dacarbazine",0.0510982390297863,0.0390538042661686,FALSE
+"H2126","Pearson.est","DNA inhibitor",0.31703,0.857,0.604,345,0.801,"carmustine, chlorambucil, oxaliplatin, teroxirone, valrubicin, carboplatin, melphalan",0.218963061378868,0.0963674839157623,FALSE
+"H2126","Pearson.est","DNA methyltransferase inhibitor",0.57039,1.53,0.0829,235,0.336,"decitabine, disulfiram",1.08144546944973,0.473660722610156,FALSE
+"H2126","Pearson.est","DNA polymerase inhibitor",0.38055,1.03,0.38,124,0.67,"trifluridine, adefovir.dipivoxil",0.42021640338319,0.173925197299174,FALSE
+"H2126","Pearson.est","DNA synthesis inhibitor",-0.44043,-1.1,0.352,1439,0.739,"estramustine.phosphate, altretamine",0.453457336521869,0.131355561605174,FALSE
+"H2126","Pearson.est","dopamine receptor antagonist",-0.39651,-0.999,0.46,1354,0.795,"clebopride, remoxipride, nemonapride, piperacetazine",0.337242168318426,0.0996328713435297,FALSE
+"H2126","Pearson.est","estrogen receptor agonist",0.34615,0.921,0.521,59,0.787,"ethinyl.estradiol",0.283162276700476,0.104025267640935,FALSE
+"H2126","Pearson.est","estrogen receptor antagonist",-0.33609,-0.867,0.598,838,0.957,"tamoxifen, danazol, clomifene, fulvestrant",0.223298816011589,0.0190880622231565,FALSE
+"H2126","Pearson.est","FGFR inhibitor",0.48616,1.29,0.163,180,0.487,"erdafitinib, regorafenib, nintedanib, dovitinib",0.787812395596042,0.312471038785366,FALSE
+"H2126","Pearson.est","FLT3 inhibitor",0.43441,1.17,0.273,239,0.51,"sorafenib, tyrphostin.AG.1296, ponatinib, KW.2449, dovitinib, TG.101348, ENMD.2076",0.563837352959244,0.292429823902064,FALSE
+"H2126","Pearson.est","glucocorticoid receptor agonist",-0.23779,-0.602,0.922,1103,0.917,"fluorometholone, betamethasone, methylprednisolone, rimexolone, flumethasone, hydrocortisone",0.0352690789463706,0.0376306643299789,FALSE
+"H2126","Pearson.est","glutamate receptor antagonist",-0.43661,-1.1,0.333,1056,0.739,"ACDPP, kynurenic.acid, tiletamine, diazooxonorleucine, CPP, latrepirdine, LY456236, JNJ.16259685",0.47755576649368,0.131355561605174,FALSE
+"H2126","Pearson.est","glycogen synthase kinase inhibitor",-0.31524,-0.802,0.713,1015,0.977,"kenpaullone, LY2090314, GSK.3.inhibitor.IX, indirubin",0.146910470148134,0.0101054362812269,FALSE
+"H2126","Pearson.est","growth factor receptor inhibitor",0.45669,1.2,0.252,185,0.513,"GSK1838705A, PHA.848125",0.598599459218456,0.289882634888184,FALSE
+"H2126","Pearson.est","HCV inhibitor",0.43039,1.18,0.273,114,0.519,"narlaprevir, mericitabine",0.563837352959244,0.284832642151542,FALSE
+"H2126","Pearson.est","HDAC inhibitor",-0.61559,-1.54,0.0871,1214,0.398,"PCI.24781, scriptaid, panobinostat, entinostat, nexturastat.a, mocetinostat, M.344, romidepsin, SB.939, JNJ.26481585, tacedinaline",1.05998184499234,0.400116927926312,FALSE
+"H2126","Pearson.est","histamine receptor antagonist",-0.44426,-1.15,0.297,1241,0.758,"zolantidine, BF2.649, lafutidine, famotidine, ranitidine, chloropyramine",0.527243550682788,0.120330794367946,FALSE
+"H2126","Pearson.est","HMGCR inhibitor",0.64066,1.69,0.0536,388,0.438,"atorvastatin, fluvastatin, mevastatin",1.27083521030723,0.3585258894959,FALSE
+"H2126","Pearson.est","HSP inhibitor",0.49137,1.28,0.207,182,0.446,"BIIB021, NMS.E973, SNX.2112, SNX.5422, PU.H71, NVP.AUY922",0.684029654543082,0.350665141287858,FALSE
+"H2126","Pearson.est","JAK inhibitor",-0.24966,-0.637,0.901,1377,0.93,"CEP.33779, pacritinib",0.045275209020937,0.0315170514460649,FALSE
+"H2126","Pearson.est","KIT inhibitor",0.52204,1.39,0.137,76,0.399,"sorafenib, masitinib, OSI.930, regorafenib",0.863279432843593,0.399027104313252,FALSE
+"H2126","Pearson.est","MDM inhibitor",-0.53988,-1.41,0.121,1415,0.545,"RITA",0.91721462968355,0.263603497723358,FALSE
+"H2126","Pearson.est","MEK inhibitor",0.21669,0.572,0.942,436,0.991,"PD.318088, PD.0325901, AZD8330, Ro.4987655, AS.703026, MEK162, trametinib, cobimetinib, U.0126",0.0259490972071227,0.00392634551472468,FALSE
+"H2126","Pearson.est","MET inhibitor",-0.5142,-1.32,0.168,1198,0.577,"PHA.665752, NVP.BVU972, PF.04217903, INC.280",0.774690718274137,0.238824186844269,FALSE
+"H2126","Pearson.est","microtubule inhibitor",-0.29198,-0.734,0.777,1178,0.966,"cytochalasin.b, colchicine, estramustine.phosphate",0.109578981199086,0.0150228735845067,FALSE
+"H2126","Pearson.est","mTOR inhibitor",-0.41914,-1.05,0.39,863,0.73,"LY303511, torin.2, NVP.BEZ235, MLN0128, torin.1, GSK2126458, sirolimus, everolimus, SB.2343, WYE.125132, AZD8055, PKI.179, PF.05212384, GDC.0980, PI.103, temsirolimus, PP242, palomid.529, LY3023414, deforolimus",0.408935392973501,0.136677139879544,FALSE
+"H2126","Pearson.est","NFkB pathway inhibitor",-0.2832,-0.718,0.809,1024,0.961,"BAY.11.7085, IKK.2.inhibitor.V, bindarit, tyloxapol",0.0920514783877277,0.0172766123314547,FALSE
+"H2126","Pearson.est","opioid receptor agonist",0.37398,1.03,0.39,198,0.67,"trimebutine, spiradoline",0.408935392973501,0.173925197299174,FALSE
+"H2126","Pearson.est","p38 MAPK inhibitor",0.30544,0.812,0.671,12,0.804,"talmapimod",0.173277479831008,0.0947439512515487,FALSE
+"H2126","Pearson.est","PARP inhibitor",0.57439,1.54,0.0948,410,0.358,"niraparib, olaparib, talazoparib, AZD2461, PJ.34",1.02319166266193,0.446116973356126,FALSE
+"H2126","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.48043,1.3,0.189,180,0.501,"sorafenib, masitinib, regorafenib, linifanib, ponatinib, axitinib, nintedanib, dovitinib",0.723538195826756,0.300162274132754,FALSE
+"H2126","Pearson.est","phosphatase inhibitor",-0.26291,-0.664,0.841,1397,0.925,"mycophenolate.mofetil",0.0752040042020878,0.0338582672609674,FALSE
+"H2126","Pearson.est","phosphodiesterase inhibitor",-0.4173,-1.06,0.369,1252,0.745,"EMD.53998, cilostamide, GSK256066",0.43297363384094,0.127843727251707,FALSE
+"H2126","Pearson.est","PI3K inhibitor",-0.30872,-0.788,0.725,863,0.909,"LY303511, NVP.BEZ235, PI3K.IN.2, TG.100713, BGT226, GSK2126458, taselisib, alpelisib, YM.201636, SB.2343, PKI.179, CUDC.907, PF.05212384, GDC.0980, PI.103, AZD6482, PI.828, LY3023414, idelalisib",0.139661993429006,0.0414361167780325,FALSE
+"H2126","Pearson.est","PLK inhibitor",0.78791,2.05,0.00242,109,0.137,"rigosertib, volasertib, GW.843682X, NMS.1286937",2.61618463401957,0.863279432843593,TRUE
+"H2126","Pearson.est","potassium channel blocker",-0.69503,-1.75,0.0221,1140,0.201,"meglitinide, oleoylethanolamide, ibutilide",1.65560772631489,0.696803942579511,TRUE
+"H2126","Pearson.est","PPAR receptor agonist",-0.55192,-1.4,0.114,1315,0.511,"oleoylethanolamide, clofibrate, GW.501516",0.943095148663527,0.291579099865287,FALSE
+"H2126","Pearson.est","progesterone receptor agonist",0.25427,0.656,0.855,358,0.936,"norethindrone, norgestrel, melengestrol.acetate, tanaproget",0.0680338852718274,0.0287241512618947,FALSE
+"H2126","Pearson.est","proteasome inhibitor",0.42485,1.14,0.296,519,0.536,"MG.132, delanzomib, ixazomib, oprozomib, bortezomib, carfilzomib",0.528708288941061,0.27083521030723,FALSE
+"H2126","Pearson.est","protein synthesis inhibitor",0.29477,0.79,0.714,393,0.817,"thiostrepton, anguidine, mercaptopurine, tedizolid.phosphate, florfenicol, cycloheximide, harringtonine",0.146301788223826,0.0877779434675845,FALSE
+"H2126","Pearson.est","protein tyrosine kinase inhibitor",-0.49492,-1.25,0.198,1330,0.634,"BMS.599626, CP.724714",0.703334809738469,0.197910742118267,FALSE
+"H2126","Pearson.est","RAF inhibitor",0.52649,1.42,0.108,225,0.42,"sorafenib, regorafenib, SB.590885, dabrafenib, RAF265",0.96657624451305,0.3767507096021,FALSE
+"H2126","Pearson.est","RET tyrosine kinase inhibitor",0.51763,1.39,0.154,76,0.399,"sorafenib, regorafenib",0.812479279163537,0.399027104313252,FALSE
+"H2126","Pearson.est","retinoid receptor agonist",0.5629,1.51,0.0806,177,0.331,"LE.135, tamibarotene, fenretinide",1.09366495819491,0.480172006224281,FALSE
+"H2126","Pearson.est","ribonucleotide reductase inhibitor",0.34151,0.913,0.495,160,0.776,"triapine, cladribine",0.305394801066431,0.110138278741812,FALSE
+"H2126","Pearson.est","serotonin receptor agonist",-0.70709,-1.81,0.00831,1369,0.174,"NAN.190, aripiprazole",2.08039897621589,0.7594507517174,TRUE
+"H2126","Pearson.est","serotonin receptor antagonist",-0.49807,-1.27,0.205,1447,0.638,"aripiprazole",0.688246138944246,0.195179321278838,FALSE
+"H2126","Pearson.est","sodium channel blocker",-0.27649,-0.7,0.815,1097,0.959,"triamterene, quinidine, ajmaline, lappaconite",0.0888423912600234,0.0181813928293364,FALSE
+"H2126","Pearson.est","src inhibitor",-0.46915,-1.19,0.273,1240,0.716,"bosutinib, PP.2, PP.1",0.563837352959244,0.145086977692144,FALSE
+"H2126","Pearson.est","sterol demethylase inhibitor",0.50279,1.28,0.197,164,0.446,"chlormidazole, sulconazole",0.705533773838407,0.350665141287858,FALSE
+"H2126","Pearson.est","TGF beta receptor inhibitor",0.45722,1.24,0.22,167,0.48,"SB.431542",0.657577319177794,0.318758762624413,FALSE
+"H2126","Pearson.est","thymidylate synthase inhibitor",0.33469,0.923,0.537,133,0.812,"trifluridine, capecitabine",0.270025714300444,0.0904439707588247,FALSE
+"H2126","Pearson.est","topoisomerase inhibitor",0.62645,1.69,0.0238,289,0.438,"etoposide.phosphate, idarubicin, topotecan, TAS.103, voreloxin, doxorubicin, nemorubicin, mitoxantrone, SN.38, exatecan.mesylate, daunorubicin, valrubicin, amonafide, teniposide",1.62342304294349,0.3585258894959,FALSE
+"H2126","Pearson.est","tubulin polymerization inhibitor",0.58268,1.57,0.0678,325,0.36,"verubulin, vinblastine, docetaxel, BNC105, vindesine, podophyllotoxin, taltobulin, fosbretabulin, albendazole, combretastatin.A.4, dolastatin.10, plinabulin, flubendazole, mebendazole, vincristine, indibulin",1.16877030613294,0.443697499232713,FALSE
+"H2126","Pearson.est","tyrosine kinase inhibitor",0.26878,0.712,0.788,219,0.912,"sorafenib, regorafenib, hypericin, tivantinib, UNC2250, mubritinib",0.103473782510445,0.0400051616715838,FALSE
+"H2126","Pearson.est","VEGFR inhibitor",0.32813,0.879,0.585,276,0.787,"sorafenib, tivozanib, OSI.930, regorafenib, linifanib, axitinib, nintedanib, dovitinib, RAF265, ENMD.2076, MGCD.265",0.23284413391782,0.104025267640935,FALSE
+"H2126","Pearson.est","vitamin D receptor agonist",-0.54259,-1.35,0.137,1001,0.565,"tacalcitol, calcitriol, maxacalcitol, paricalcitol",0.863279432843593,0.247951552180562,FALSE
+"H520","Pearson.est","EGFR inhibitor",-0.40163,-1.01,0.436,1055,0.872,"PD.168393, WZ.4002, dacomitinib, dovitinib, brigatinib, salvianolic.acid.B, AZD8931, gefitinib, TAK.285, ARRY.334543, XL.647, lapatinib, CP.724714, tucatinib, AEE788, rociletinib, neratinib, GW.583340",0.360513510731414,0.0594835150674328,FALSE
+"H520","Pearson.est","Abl kinase inhibitor",-0.46688,-1.16,0.295,944,0.899,"dasatinib, bosutinib, imatinib, GZD824, flumatinib, metatinib, ponatinib, bafetinib, nilotinib",0.530177984021837,0.0462403082667712,FALSE
+"H520","Pearson.est","acetylcholine receptor agonist",0.53333,1.39,0.125,198,0.444,"nicotine, nefiracetam",0.903089986991944,0.35261702988538,FALSE
+"H520","Pearson.est","acetylcholine receptor antagonist",-0.58687,-1.46,0.0856,1051,0.807,"methscopolamine, hyoscyamine, diphemanil",1.06752623532285,0.0931264652779296,FALSE
+"H520","Pearson.est","adenosine receptor antagonist",-0.2068,-0.515,0.96,298,0.973,"istradefylline, MRS.1220, SCH.58261, PSB.1115, sulmazole, CGS.15943, theophylline",0.0177287669604316,0.0118871597316481,FALSE
+"H520","Pearson.est","adrenergic receptor agonist",0.27738,0.696,0.823,306,0.937,"oxymetazoline, isoxsuprine, terbutaline, buphenine, clenbuterol, metaraminol",0.0846001647877302,0.0282604091122217,FALSE
+"H520","Pearson.est","adrenergic receptor antagonist",-0.4522,-1.15,0.289,1137,0.821,"naftidrofuryl, vincamine, metoprolol, idazoxan, carvedilol, prazosin, practolol, RS.17053, dihydroergocristine",0.539102157243452,0.0856568428805592,FALSE
+"H520","Pearson.est","AKT inhibitor",0.51098,1.34,0.173,366,0.402,"MK.2206, palomid.529, GDC.0068, AT7867, AZD5363, ONC201, CCT128930",0.761953896871205,0.39577394691553,FALSE
+"H520","Pearson.est","ALK tyrosine kinase receptor inhibitor",-0.4083,-1.02,0.413,1016,0.883,"NVP.TAE684, crizotinib, AZD3463, brigatinib, DMH1, AP26113, CEP.37440",0.384049948343599,0.0540392964224314,FALSE
+"H520","Pearson.est","androgen receptor antagonist",0.51744,1.34,0.161,121,0.402,"RU.58841, nilutamide",0.79317412396815,0.39577394691553,FALSE
+"H520","Pearson.est","antioxidant",0.54537,1.42,0.102,80,0.437,"mesna, benfotiamine",0.991399828238082,0.359518563029578,FALSE
+"H520","Pearson.est","AP inhibitor",0.65751,1.69,0.0271,66,0.211,"birinapant, GDC.0152",1.56703070912559,0.675717544702307,TRUE
+"H520","Pearson.est","ATPase inhibitor",-0.21253,-0.523,0.963,1075,0.989,"oligomycin.a, digoxin, digitoxin, evodiamine",0.0163737128754655,0.0048037084028206,FALSE
+"H520","Pearson.est","Aurora kinase inhibitor",-0.27819,-0.699,0.833,1054,0.955,"MK.5108, barasertib.HQPA, SNS.314, TAK.901, CCT137690, AT.9283, CYC116, danusertib, PHA.680632",0.0793549985932124,0.0199966284162537,FALSE
+"H520","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.31082,-0.804,0.692,935,0.958,"valnemulin, azithromycin, josamycin, dirithromycin",0.159893905543242,0.0186344909214556,FALSE
+"H520","Pearson.est","bacterial DNA gyrase inhibitor",0.7398,1.91,0.00665,45,0.108,"finafloxacin, novobiocin, trovafloxacin",2.1771783546969,0.96657624451305,TRUE
+"H520","Pearson.est","BCL inhibitor",0.43576,1.11,0.304,137,0.505,"venetoclax, oridonin, HA14.1",0.517126416391246,0.296708621881339,FALSE
+"H520","Pearson.est","Bcr.Abl kinase inhibitor",-0.63063,-1.53,0.0693,944,0.689,"dasatinib, bosutinib, imatinib, GZD824, flumatinib, metatinib, ponatinib, bafetinib, nilotinib",1.15926676538819,0.161780778092374,FALSE
+"H520","Pearson.est","benzodiazepine receptor agonist",-0.27515,-0.7,0.829,1202,0.976,"ZK.93423, bentazepam, indiplon",0.0814454694497265,0.0105501823333082,FALSE
+"H520","Pearson.est","bromodomain inhibitor",-0.69606,-1.72,0.0216,1119,0.533,"OTX015, bromosporine, I.BET.762, PFI.1",1.66554624884907,0.273272790973428,FALSE
+"H520","Pearson.est","calcium channel blocker",0.41509,1.09,0.36,209,0.51,"cinnarazine, efonidipine.monoethanolate, SR.33805, pranidipine",0.443697499232713,0.292429823902064,FALSE
+"H520","Pearson.est","CC chemokine receptor antagonist",-0.35896,-0.877,0.587,1406,0.934,"UNBS.5162",0.231361898752386,0.0296531237699066,FALSE
+"H520","Pearson.est","CDK inhibitor",-0.31589,-0.777,0.73,1019,0.978,"abemaciclib, CR8..R., indisulam, aminopurvalanol.a, PHA.848125, arcyriaflavin.a, dinaciclib, AT.7519, BMS.387032",0.136677139879544,0.00966114521239857,FALSE
+"H520","Pearson.est","CHK inhibitor",-0.46846,-1.17,0.246,1313,0.931,"SB.218078, PF.477736",0.609064892896621,0.0310503190186574,FALSE
+"H520","Pearson.est","cyclooxygenase inhibitor",0.22173,0.575,0.958,319,1,"metoxibutropate, FR.122047, phenylbutazone, indoprofen, aspirin, amfenac, suxibuzone, curcumin, acetylsalicylsalicylic.acid",0.0186344909214556,0,FALSE
+"H520","Pearson.est","cytochrome P450 inhibitor",-0.23838,-0.587,0.927,972,0.99,"morin, eplerenone, metyrapone",0.0329202658555029,0.00436480540245009,FALSE
+"H520","Pearson.est","DNA alkylating agent",-0.46172,-1.17,0.284,1010,0.931,"satraplatin, temozolomide, melphalan, ifosfamide, dacarbazine, dianhydrogalactitol, mitomycin.c",0.546681659952962,0.0310503190186574,FALSE
+"H520","Pearson.est","DNA inhibitor",-0.26839,-0.678,0.836,969,0.96,"oxaliplatin, valrubicin, pibenzimol, melphalan, teroxirone, primaquine, mechlorethamine, bendamustine",0.0777937225609836,0.0177287669604316,FALSE
+"H520","Pearson.est","DNA methyltransferase inhibitor",0.50627,1.3,0.184,146,0.427,"azacitidine, decitabine",0.735182176990464,0.369572124974976,FALSE
+"H520","Pearson.est","DNA polymerase inhibitor",0.59836,1.54,0.0888,513,0.313,"famciclovir, cephalomannine, adefovir.dipivoxil, trifluridine, cidofovir, foscarnet, menadione",1.0515870342214,0.504455662453552,FALSE
+"H520","Pearson.est","DNA synthesis inhibitor",0.20012,0.517,0.969,201,0.974,"CB.10.277, capecitabine, altretamine",0.0136762229492347,0.0114410431213845,FALSE
+"H520","Pearson.est","dopamine receptor antagonist",0.48935,1.27,0.207,322,0.436,"clebopride, acetophenazine, oxiperomide, UH.232...., ziprasidone, domperidone, raclopride, mesoridazine, remoxipride, paliperidone",0.684029654543082,0.360513510731414,FALSE
+"H520","Pearson.est","estrogen receptor agonist",-0.28534,-0.701,0.78,1229,0.999,"equol, levonorgestrel",0.10790539730952,0.000434511774017692,FALSE
+"H520","Pearson.est","estrogen receptor antagonist",-0.5618,-1.39,0.104,1245,0.728,"toremifene, tamoxifen",0.98296666070122,0.137868620686963,FALSE
+"H520","Pearson.est","FGFR inhibitor",-0.54587,-1.37,0.151,1047,0.705,"AZD4547, dovitinib, nintedanib, regorafenib, erdafitinib, lenvatinib",0.821023052706831,0.151810883008601,FALSE
+"H520","Pearson.est","FLT3 inhibitor",-0.32392,-0.808,0.668,908,0.978,"ENMD.2076, lestaurtinib, midostaurin, dovitinib, ponatinib, tyrphostin.AG.1296, TG.101348, quizartinib",0.175223537524454,0.00966114521239857,FALSE
+"H520","Pearson.est","glucocorticoid receptor agonist",-0.38983,-0.969,0.477,1122,0.893,"flumethasone.pivalate, clobetasol.propionate, methylprednisolone, flumethasone, fluticasone.propionate, halcinonide, triamcinolone.acetonide, fluorometholone, betamethasone, deflazacort",0.321481620959886,0.0491485411114536,FALSE
+"H520","Pearson.est","glutamate receptor antagonist",-0.29125,-0.723,0.796,1307,1,"ACDPP, CGP.37849, LY456236",0.0990869322623309,0,FALSE
+"H520","Pearson.est","glycogen synthase kinase inhibitor",0.45609,1.17,0.276,303,0.445,"LY2090314, kenpaullone, indirubin, tideglusib",0.559090917934782,0.351639989019068,FALSE
+"H520","Pearson.est","growth factor receptor inhibitor",-0.38439,-0.965,0.505,939,0.87,"lestaurtinib, AZD3463, PHA.848125, danusertib",0.296708621881339,0.0604807473813815,FALSE
+"H520","Pearson.est","HCV inhibitor",-0.36301,-0.919,0.531,1007,0.877,"narlaprevir, PSI.7976, mericitabine",0.274905478918531,0.0570004066339595,FALSE
+"H520","Pearson.est","HDAC inhibitor",0.36545,0.939,0.486,216,0.667,"romidepsin, JNJ.26481585, R306465, RGFP966, tacedinaline, pyroxamide",0.313363730737707,0.175874166083451,FALSE
+"H520","Pearson.est","histamine receptor antagonist",0.1996,0.517,0.954,394,0.974,"epinastine, ranitidine, terfenadine, levocetirizine, tecastemizole, famotidine",0.0204516252959049,0.0114410431213845,FALSE
+"H520","Pearson.est","HMGCR inhibitor",0.72469,1.88,0.0119,403,0.102,"pitavastatin, fluvastatin, lovastatin, atorvastatin, mevastatin, simvastatin",1.92445303860747,0.991399828238082,TRUE
+"H520","Pearson.est","HSP inhibitor",0.5203,1.38,0.126,468,0.415,"BIIB021, PU.H71, SNX.5422, KW.2478, VER.49009, NVP.AUY922, SNX.2112, tanespimycin",0.899629454882437,0.381951903287907,FALSE
+"H520","Pearson.est","JAK inhibitor",-0.39686,-0.982,0.479,939,0.897,"lestaurtinib, ruxolitinib, TG.101209, baricitinib, CEP.33779, AT.9283, TG.101348, LY2784544",0.319664486585437,0.0472075569559079,FALSE
+"H520","Pearson.est","KIT inhibitor",-0.41813,-1.04,0.405,854,0.916,"sorafenib, cediranib, dasatinib, midostaurin, imatinib, masitinib, regorafenib, pazopanib, lenvatinib",0.392544976785331,0.0381045263321496,FALSE
+"H520","Pearson.est","MDM inhibitor",0.71768,1.92,0.00728,213,0.149,"RITA, idasanutlin, serdemetan, nutlin.3",2.13786862068696,0.826813731587726,TRUE
+"H520","Pearson.est","MEK inhibitor",0.84218,2.19,0,95,0.0165,"AZD8330, TAK.733, PD.0325901, Ro.4987655, PD.184352, refametinib, AS.703026, cobimetinib, PD.318088, trametinib, MEK162, selumetinib",Inf,1.78251605578609,TRUE
+"H520","Pearson.est","MET inhibitor",0.22676,0.588,0.95,413,1,"AMG458, PF.04217903, INC.280",0.0222763947111523,0,FALSE
+"H520","Pearson.est","microtubule inhibitor",-0.56865,-1.4,0.141,1352,0.788,"cabazitaxel, D.64131, colchicine",0.85078088734462,0.103473782510445,FALSE
+"H520","Pearson.est","mTOR inhibitor",-0.32998,-0.809,0.686,992,1,"torin.1, NVP.BEZ235, SB.2343, AZD8055, PF.05212384, PKI.179, WYE.354, MLN0128, deforolimus, PF.04691502, WYE.125132",0.163675884293248,0,FALSE
+"H520","Pearson.est","NFkB pathway inhibitor",0.37023,0.949,0.485,147,0.678,"BAY.11.7085, betulinic.acid",0.314258261397736,0.168770306132937,FALSE
+"H520","Pearson.est","opioid receptor agonist",0.69851,1.79,0.0349,308,0.148,"cebranopadol, BW.180C, salvinorin.a, ADL5859",1.45717457304082,0.829738284605043,TRUE
+"H520","Pearson.est","p38 MAPK inhibitor",-0.37378,-0.93,0.521,1446,0.883,"talmapimod",0.283162276700476,0.0540392964224314,FALSE
+"H520","Pearson.est","PARP inhibitor",-0.26875,-0.671,0.854,387,0.947,"AZD2461, AG.14361, olaparib, talazoparib, endo.IWR.1, E7449, niraparib, PJ.34",0.068542129310995,0.0236500209967266,FALSE
+"H520","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.32954,-0.826,0.656,1044,1,"imatinib, dovitinib, masitinib, nintedanib, ponatinib, crenolanib, regorafenib, pazopanib, lenvatinib",0.18309616062434,0,FALSE
+"H520","Pearson.est","phosphatase inhibitor",0.27772,0.718,0.806,129,0.938,"bis.maltolato.oxovanadium.IV., alexidine",0.0936649581949093,0.0277971616209356,FALSE
+"H520","Pearson.est","phosphodiesterase inhibitor",0.47899,1.25,0.201,369,0.41,"papaverine, anagrelide, zardaverine, EMD.53998",0.696803942579511,0.387216143280265,FALSE
+"H520","Pearson.est","PI3K inhibitor",-0.22154,-0.562,0.928,933,0.986,"taselisib, idelalisib, NVP.BEZ235, SB.2343, YM.201636, PIK.75, PI3K.IN.2, BGT226, PF.05212384, PKI.179, PF.04691502, ZSTK.474",0.0324520237811379,0.0061230850587888,FALSE
+"H520","Pearson.est","PLK inhibitor",-0.82878,-2.07,0,1251,0.0426,"HMN.214, GW.843682X, BI.2536, volasertib, GSK461364, NMS.1286937",Inf,1.37059040089728,TRUE
+"H520","Pearson.est","potassium channel blocker",0.49171,1.26,0.208,44,0.422,"meglitinide",0.681936665037238,0.374687549038326,FALSE
+"H520","Pearson.est","PPAR receptor agonist",0.3386,0.84,0.643,75,0.803,"S26948",0.191789027075778,0.095284454721319,FALSE
+"H520","Pearson.est","progesterone receptor agonist",-0.25194,-0.621,0.911,901,0.98,"danazol, melengestrol.acetate, nomegestrol.acetate, levonorgestrel",0.0404816230270017,0.00877392430750515,FALSE
+"H520","Pearson.est","proteasome inhibitor",0.2875,0.738,0.802,1034,0.941,"ixazomib, ixazomib.citrate, MG.132, ONX.0914, bortezomib, oprozomib, delanzomib, carfilzomib",0.0958256317158365,0.0264103765727431,FALSE
+"H520","Pearson.est","protein synthesis inhibitor",-0.55782,-1.35,0.139,1283,0.69,"puromycin, mercaptopurine, clofoctol, bruceantin, harringtonine, anguidine, homoharringtonine",0.856985199745905,0.161150909262745,FALSE
+"H520","Pearson.est","protein tyrosine kinase inhibitor",-0.63833,-1.58,0.0597,1115,0.872,"rheochrysidin, mubritinib, tyrphostin.A9, PP.121, CP.724714, AV.412",1.22402566887063,0.0594835150674328,FALSE
+"H520","Pearson.est","RAF inhibitor",-0.28813,-0.709,0.842,1342,1,"regorafenib, TAK.632",0.0746879085003505,0,FALSE
+"H520","Pearson.est","RET tyrosine kinase inhibitor",-0.37905,-0.947,0.508,1342,0.877,"regorafenib",0.294136287716081,0.0570004066339595,FALSE
+"H520","Pearson.est","retinoid receptor agonist",-0.44488,-1.1,0.346,954,0.854,"tamibarotene, AM.580, bexarotene, fenretinide",0.460923901207223,0.068542129310995,FALSE
+"H520","Pearson.est","ribonucleotide reductase inhibitor",-0.45984,-1.15,0.311,1272,0.821,"clofarabine, LY2334737, pentostatin",0.507239610973163,0.0856568428805592,FALSE
+"H520","Pearson.est","serotonin receptor agonist",0.62914,1.68,0.0392,127,0.191,"aripiprazole, ipsapirone",1.40671393297954,0.718966632752272,TRUE
+"H520","Pearson.est","serotonin receptor antagonist",0.47089,1.22,0.261,322,0.425,"aripiprazole, lerisetron, ziprasidone, RS.16566, tropisetron, paliperidone",0.583359492661719,0.371611069949688,FALSE
+"H520","Pearson.est","sodium channel blocker",0.38468,1,0.419,76,0.62,"ajmaline, A.803467",0.377785977033705,0.207608310501746,FALSE
+"H520","Pearson.est","src inhibitor",-0.45988,-1.18,0.255,944,1,"dasatinib, bosutinib, masitinib, TG.100572, PP.1, KX2.391, saracatinib",0.593459819566045,0,FALSE
+"H520","Pearson.est","sterol demethylase inhibitor",-0.63042,-1.57,0.0578,1018,0.695,"terconazole, ketoconazole, posaconazole, lanoconazole, chlormidazole",1.23807216157947,0.158015195409886,FALSE
+"H520","Pearson.est","TGF beta receptor inhibitor",0.45354,1.19,0.247,455,0.441,"D.4476, LY2109761, SB.431542, repsox",0.607303046740334,0.355561410532161,FALSE
+"H520","Pearson.est","thymidylate synthase inhibitor",-0.44635,-1.12,0.341,1405,0.847,"doxifluridine",0.467245621007502,0.0721165896692931,FALSE
+"H520","Pearson.est","topoisomerase inhibitor",-0.57424,-1.43,0.117,1155,0.795,"epirubicin, daunorubicin, idarubicin, licochalcone.a, teniposide, etoposide.phosphate, amonafide, dexrazoxane, etoposide, TAS.103, doxorubicin, exatecan.mesylate, nemorubicin, SN.38, amsacrine, mitoxantrone",0.931814138253838,0.0996328713435297,FALSE
+"H520","Pearson.est","tubulin polymerization inhibitor",-0.51161,-1.28,0.175,987,0.821,"nocodazole, plinabulin, taltobulin, vindesine, docetaxel, vincristine, epothilone.b, mebendazole, epothilone.d, dolastatin.10, KX2.391, paclitaxel, ABT.751, oxibendazole, CYT.997, fenbendazole",0.756961951313706,0.0856568428805592,FALSE
+"H520","Pearson.est","tyrosine kinase inhibitor",-0.40907,-1.02,0.428,1115,0.883,"rheochrysidin, mubritinib, aminopurvalanol.a, bafetinib, tyrphostin.A9, PP.121, CP.724714, regorafenib, AV.412",0.368556230986828,0.0540392964224314,FALSE
+"H520","Pearson.est","VEGFR inhibitor",-0.28601,-0.716,0.804,1102,1,"dovitinib, nintedanib, TG.100572, foretinib, SAR131675, XL.647, AEE788, regorafenib, pazopanib, lenvatinib",0.0947439512515487,0,FALSE
+"H520","Pearson.est","vitamin D receptor agonist",-0.42529,-1.04,0.416,1424,0.916,"doxercalciferol",0.380906669373257,0.0381045263321496,FALSE
+"H460","Pearson.est","EGFR inhibitor",-0.24982,-0.627,0.895,954,0.95,"brigatinib, CUDC.101, osimertinib, WZ8040, BMS.599626, tyrphostin.AG.1478, CGP.52411, lapatinib, tucatinib, BIBU.1361, neratinib, salvianolic.acid.B, dovitinib, WZ.4002, CP.724714",0.048176964684088,0.0222763947111523,FALSE
+"H460","Pearson.est","Abl kinase inhibitor",-0.33433,-0.855,0.636,1266,0.872,"metatinib, nilotinib, imatinib",0.196542884351586,0.0594835150674328,FALSE
+"H460","Pearson.est","acetylcholine receptor agonist",-0.41455,-1.05,0.403,1359,0.742,"oxiracetam",0.39469495385889,0.129596094720973,FALSE
+"H460","Pearson.est","acetylcholine receptor antagonist",0.74638,2.03,0.00252,210,0.0622,"diphemanil, iododexetimide, hyoscyamine, darifenacin",2.59859945921846,1.20620961530918,TRUE
+"H460","Pearson.est","adenosine receptor antagonist",0.40055,1.09,0.329,372,0.571,"CGS.15943, SCH.58261, MRS.1220",0.482804102050026,0.243363891754152,FALSE
+"H460","Pearson.est","adrenergic receptor agonist",0.47314,1.29,0.188,398,0.356,"ritodrine, xylazine, methyldopa, A61603, isoxsuprine, clenbuterol, terbutaline, norepinephrine",0.72584215073632,0.448550002027125,FALSE
+"H460","Pearson.est","adrenergic receptor antagonist",0.52075,1.41,0.12,104,0.402,"RS.17053, prazosin, atenolol...., metoprolol, practolol",0.920818753952375,0.39577394691553,FALSE
+"H460","Pearson.est","AKT inhibitor",-0.34752,-0.87,0.594,1392,0.891,"uprosertib, AT7867",0.226213555018806,0.0501222959631252,FALSE
+"H460","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.5019,1.31,0.171,282,0.418,"lorlatinib, NVP.TAE684, GW.788388, AP26113, CEP.37440",0.767003889607846,0.378823718224965,FALSE
+"H460","Pearson.est","androgen receptor antagonist",-0.3221,-0.822,0.675,1313,0.907,"RU.58841",0.170696227168975,0.0423927129399047,FALSE
+"H460","Pearson.est","antioxidant",-0.66876,-1.71,0.0207,1206,0.415,"trolox, chlorogenic.acid, mesna",1.68402965454308,0.381951903287907,FALSE
+"H460","Pearson.est","AP inhibitor",0.34209,0.914,0.548,86,0.675,"tanshinone.i",0.261219441515631,0.170696227168975,FALSE
+"H460","Pearson.est","ATPase inhibitor",-0.41793,-1.04,0.394,1101,0.686,"digitoxigenin, ouabain, digitoxin, omeprazole, NMS.873, digoxin",0.404503778174426,0.163675884293248,FALSE
+"H460","Pearson.est","Aurora kinase inhibitor",-0.52542,-1.32,0.174,1057,0.638,"MLN.8054, MK.5108, KW.2449, PF.03814735, hesperadin, alisertib, CCT137690, GSK1070916, MK.8745, CCT129202, PHA.680632, ENMD.2076",0.7594507517174,0.195179321278838,FALSE
+"H460","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.54785,-1.38,0.144,1336,0.593,"radezolid, tedizolid, azalomycin.b, valnemulin",0.84163750790475,0.226945306635737,FALSE
+"H460","Pearson.est","bacterial DNA gyrase inhibitor",0.48833,1.29,0.192,348,0.356,"sparfloxacin, norfloxacin, nadifloxacin, lomefloxacin, trovafloxacin, sarafloxacin",0.71669877129645,0.448550002027125,FALSE
+"H460","Pearson.est","BCL inhibitor",-0.60388,-1.53,0.0666,1408,0.445,"TW.37, venetoclax",1.1765257708297,0.351639989019068,FALSE
+"H460","Pearson.est","Bcr.Abl kinase inhibitor",-0.40925,-1.04,0.411,1266,0.686,"metatinib, nilotinib, imatinib",0.386158178123931,0.163675884293248,FALSE
+"H460","Pearson.est","benzodiazepine receptor agonist",0.54037,1.44,0.117,195,0.405,"indiplon, gamma.aminobutyric.acid, piperazine, temazepam, CL.218872, bentazepam",0.931814138253838,0.392544976785331,FALSE
+"H460","Pearson.est","bromodomain inhibitor",-0.28704,-0.731,0.783,875,0.943,"JQ1...., bromosporine, I.BET.762",0.106238237942057,0.0254883072626717,FALSE
+"H460","Pearson.est","calcium channel blocker",-0.22066,-0.552,0.948,1189,0.972,"SR.33805, mibefradil",0.0231916626619338,0.0123337350737254,FALSE
+"H460","Pearson.est","CC chemokine receptor antagonist",-0.453,-1.17,0.271,1268,0.782,"RS.504393, navarixin",0.567030709125594,0.106793246940152,FALSE
+"H460","Pearson.est","CDK inhibitor",-0.64369,-1.63,0.0388,1192,0.419,"R547, BMS.387032, abemaciclib, aminopurvalanol.a, TG.02, palbociclib, indirubin, alvocidib, AZD5438, PHA.793887, BMS.265246, ribociclib",1.41116827440579,0.377785977033705,FALSE
+"H460","Pearson.est","CHK inhibitor",-0.26436,-0.663,0.877,1008,0.992,"SB.218078, LY2603618, SCH.900776",0.0570004066339595,0.00348832784582135,FALSE
+"H460","Pearson.est","cyclooxygenase inhibitor",0.32339,0.865,0.586,150,0.724,"naproxen, pterostilbene, metoxibutropate, FK.3311",0.232102383981909,0.140261433802853,FALSE
+"H460","Pearson.est","cytochrome P450 inhibitor",0.81424,2.2,0,137,0.0217,"morin, itraconazole, metyrapone, eplerenone",Inf,1.66354026615147,TRUE
+"H460","Pearson.est","DNA alkylating agent",-0.43781,-1.11,0.34,1100,0.77,"estramustine, carmustine, TH.302, mitomycin.c, carboplatin",0.468521082957745,0.113509274827518,FALSE
+"H460","Pearson.est","DNA inhibitor",-0.45255,-1.14,0.312,1103,0.774,"nimorazole, carmustine, teroxirone, valrubicin, carboplatin, mechlorethamine",0.505845405981557,0.111259039317107,FALSE
+"H460","Pearson.est","DNA methyltransferase inhibitor",-0.60083,-1.52,0.0789,1153,0.417,"fdcyd, azacitidine, disulfiram, decitabine",1.10292299679058,0.379863945026242,FALSE
+"H460","Pearson.est","DNA polymerase inhibitor",0.31947,0.855,0.622,99,0.683,"famciclovir, cephalomannine",0.206209615309181,0.165579296318467,FALSE
+"H460","Pearson.est","DNA synthesis inhibitor",-0.40652,-1.04,0.398,1312,0.686,"capecitabine, cyclocytidine, floxuridine, mitomycin.c, anisomycin",0.400116927926312,0.163675884293248,FALSE
+"H460","Pearson.est","dopamine receptor antagonist",-0.20666,-0.522,0.972,988,0.97,"paliperidone, acetophenazine, oxiperomide, ziprasidone, mesoridazine, thioproperazine, UH.232....",0.0123337350737254,0.0132282657337552,FALSE
+"H460","Pearson.est","estrogen receptor agonist",-0.26032,-0.657,0.86,1068,0.957,"equol, PPT",0.0655015487564323,0.0190880622231565,FALSE
+"H460","Pearson.est","estrogen receptor antagonist",0.62329,1.66,0.0413,289,0.27,"toremifene, fulvestrant, raloxifene, tamoxifen",1.3840499483436,0.568636235841013,FALSE
+"H460","Pearson.est","FGFR inhibitor",0.404,1.08,0.335,312,0.526,"erdafitinib, lucitanib, orantinib, lenvatinib",0.474955192963155,0.279014255846261,FALSE
+"H460","Pearson.est","FLT3 inhibitor",-0.40024,-1.01,0.408,1220,0.721,"dovitinib, sunitinib, TG.02, TG.101348, pacritinib, ENMD.2076",0.38933983691012,0.142064735280571,FALSE
+"H460","Pearson.est","glucocorticoid receptor agonist",0.22773,0.62,0.875,95,0.906,"triamcinolone.acetonide, piretanide",0.0579919469776868,0.0428718023231869,FALSE
+"H460","Pearson.est","glutamate receptor antagonist",0.48841,1.28,0.212,357,0.345,"kynurenic.acid, JNJ.16259685, MTPG, LY456236, felbamate, CGP.37849, tiletamine",0.673664139071249,0.462180904926726,FALSE
+"H460","Pearson.est","glycogen synthase kinase inhibitor",-0.24751,-0.622,0.898,1195,0.936,"LY2090314, indirubin",0.0467236633326956,0.0287241512618947,FALSE
+"H460","Pearson.est","growth factor receptor inhibitor",-0.42985,-1.07,0.386,756,0.729,"AZD3463, GSK1904529A, danusertib, GSK1838705A, lestaurtinib, PHA.848125",0.413412695328245,0.137272471682025,FALSE
+"H460","Pearson.est","HCV inhibitor",-0.48754,-1.23,0.247,1446,0.679,"narlaprevir",0.607303046740334,0.168130225719498,FALSE
+"H460","Pearson.est","HDAC inhibitor",-0.5704,-1.44,0.0893,1040,0.503,"scriptaid, panobinostat, belinostat, R306465, entinostat, M.344, PCI.24781, romidepsin, RG2833, JNJ.26481585, resminostat, AR.42, dacinostat, trichostatin.a, chidamide, vorinostat, givinostat",1.04914854111145,0.298432014944073,FALSE
+"H460","Pearson.est","histamine receptor antagonist",0.32882,0.864,0.616,324,0.696,"famotidine, chloropyramine, lafutidine, cimetidine, ICI.162846, ebastine",0.210419287835575,0.157390760389438,FALSE
+"H460","Pearson.est","HMGCR inhibitor",0.71528,1.91,0.0185,323,0.105,"lovastatin, mevastatin, fluvastatin, pitavastatin, atorvastatin",1.73282827159699,0.978810700930062,TRUE
+"H460","Pearson.est","HSP inhibitor",-0.60827,-1.53,0.07,1097,0.445,"XL888, SNX.2112, BIIB021, NVP.AUY922, VER.49009, ganetespib, tanespimycin, PU.H71",1.15490195998574,0.351639989019068,FALSE
+"H460","Pearson.est","JAK inhibitor",-0.50011,-1.26,0.206,965,0.653,"atiprimod, lestaurtinib, AZD1480, TG.101209, WHI.P154, AZ960, TG.02, TG.101348, pacritinib, filgotinib",0.686132779630847,0.185086818724926,FALSE
+"H460","Pearson.est","KIT inhibitor",-0.43446,-1.09,0.364,1257,0.777,"KI.8751, sunitinib, OSI.930, imatinib",0.438898616350944,0.109578981199086,FALSE
+"H460","Pearson.est","MDM inhibitor",-0.72352,-1.84,0.015,1375,0.482,"CGM097, nutlin.3, idasanutlin",1.82390874094432,0.31695296176115,FALSE
+"H460","Pearson.est","MEK inhibitor",-0.70314,-1.78,0.0209,1289,0.378,"refametinib, PD.184352, PD.318088, Ro.4987655, cobimetinib, selumetinib, MEK162, PD.0325901, AZD8330, TAK.733, trametinib, AS.703026",1.67985371388895,0.422508200162775,FALSE
+"H460","Pearson.est","MET inhibitor",0.47952,1.3,0.173,563,0.397,"PHA.665752, NVP.BVU972, PF.04217903, INC.280",0.761953896871205,0.401209493236885,FALSE
+"H460","Pearson.est","microtubule inhibitor",0.26716,0.731,0.799,13,0.838,"estramustine.phosphate",0.0974532206860086,0.0767559813697235,FALSE
+"H460","Pearson.est","mTOR inhibitor",-0.43216,-1.08,0.366,1027,0.736,"AZD8055, voxtalisib, GDC.0980, temsirolimus, WAY.600, GSK2126458, PP242, LY303511, XL388, MLN0128, ku.0063794, AZD2014, everolimus, NVP.BEZ235",0.436518914605589,0.133122185662501,FALSE
+"H460","Pearson.est","NFkB pathway inhibitor",-0.29216,-0.742,0.797,1341,0.948,"curcumin, betulinic.acid",0.0985416786038876,0.0231916626619338,FALSE
+"H460","Pearson.est","opioid receptor agonist",-0.49745,-1.26,0.2,1419,0.653,"salvinorin.a",0.698970004336019,0.185086818724926,FALSE
+"H460","Pearson.est","p38 MAPK inhibitor",0.54527,1.4,0.126,226,0.373,"TAK.715, SB.239063",0.899629454882437,0.428291168191312,FALSE
+"H460","Pearson.est","PARP inhibitor",-0.43053,-1.11,0.333,1125,0.77,"niraparib, endo.IWR.1, talazoparib, olaparib",0.47755576649368,0.113509274827518,FALSE
+"H460","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.51796,-1.34,0.172,1084,0.636,"nintedanib, vatalanib, trapidil, CP.673451, linifanib, dovitinib, KI.8751, sunitinib, axitinib, crenolanib, imatinib",0.764471553092451,0.196542884351586,FALSE
+"H460","Pearson.est","phosphatase inhibitor",0.58842,1.56,0.0869,553,0.344,"BVT.948, AS.1949490, alexidine, mycophenolate.mofetil, mycophenolic.acid, menadione, GSK2830371, sodium.stibogluconate, CID.5458317",1.06098022355133,0.46344155742847,FALSE
+"H460","Pearson.est","phosphodiesterase inhibitor",0.36522,0.965,0.479,142,0.683,"enoximone, GSK256066",0.319664486585437,0.165579296318467,FALSE
+"H460","Pearson.est","PI3K inhibitor",-0.39331,-0.988,0.47,1091,0.741,"CH5132799, GDC.0980, alpelisib, PIK.75, GSK2126458, TG.100713, LY303511, CUDC.907, NVP.BEZ235",0.327902142064283,0.130181792020672,FALSE
+"H460","Pearson.est","PLK inhibitor",-0.6541,-1.63,0.0328,1217,0.419,"GW.843682X, volasertib, NMS.1286937, rigosertib",1.48412615628832,0.377785977033705,FALSE
+"H460","Pearson.est","potassium channel blocker",0.39862,1.08,0.337,129,0.526,"dofetilide, ibutilide",0.472370099128661,0.279014255846261,FALSE
+"H460","Pearson.est","PPAR receptor agonist",0.66959,1.78,0.0428,241,0.176,"pterostilbene, GW.501516, fenofibrate, S26948",1.36855623098683,0.75448733218585,TRUE
+"H460","Pearson.est","progesterone receptor agonist",0.55353,1.47,0.0998,291,0.415,"norgestrel, nomegestrol.acetate, norethindrone.acetate, dienogest",1.00086945871263,0.381951903287907,FALSE
+"H460","Pearson.est","proteasome inhibitor",0.51479,1.38,0.12,259,0.362,"oprozomib, ONX.0914, delanzomib",0.920818753952375,0.441291429466834,FALSE
+"H460","Pearson.est","protein synthesis inhibitor",-0.26844,-0.676,0.838,1179,0.999,"emetine, homoharringtonine, anguidine, tedizolid.phosphate, thiostrepton",0.0767559813697235,0.000434511774017692,FALSE
+"H460","Pearson.est","protein tyrosine kinase inhibitor",-0.48258,-1.26,0.229,1022,0.653,"BMS.599626, NVP.TAE226, AV.412, CP.724714, mubritinib",0.640164517660112,0.185086818724926,FALSE
+"H460","Pearson.est","RAF inhibitor",-0.36256,-0.905,0.558,932,0.849,"RAF265, SB.590885, vemurafenib, TAK.632, AZ.628, CEP.32496, dabrafenib",0.253365801062421,0.0710923097560473,FALSE
+"H460","Pearson.est","RET tyrosine kinase inhibitor",-0.2658,-0.659,0.875,1274,0.975,"sunitinib",0.0579919469776868,0.0109953843014632,FALSE
+"H460","Pearson.est","retinoid receptor agonist",-0.31124,-0.799,0.684,1058,0.901,"tamibarotene, CD.437, bexarotene, adarotene",0.164943898279884,0.045275209020937,FALSE
+"H460","Pearson.est","ribonucleotide reductase inhibitor",0.35143,0.942,0.505,942,0.689,"hydroxyurea, clofarabine, pentostatin, cladribine, cytarabine, fludarabine, triapine, gemcitabine, fludarabine.phosphate, LY2334737",0.296708621881339,0.161780778092374,FALSE
+"H460","Pearson.est","serotonin receptor antagonist",-0.30645,-0.766,0.743,988,0.932,"paliperidone, RS.16566, pirenperone, ziprasidone, SB.200646, SB.216641",0.129011186239425,0.0305840876460186,FALSE
+"H460","Pearson.est","sodium channel blocker",0.34661,0.939,0.506,344,0.662,"cibenzoline, oxcarbazepine, benzethonium, benzocaine, quinidine",0.295849483160201,0.1791420105603,FALSE
+"H460","Pearson.est","src inhibitor",-0.24982,-0.628,0.91,1173,0.968,"TG.100572, KX2.391",0.0409586076789064,0.0141246426916063,FALSE
+"H460","Pearson.est","sterol demethylase inhibitor",-0.36313,-0.926,0.541,914,0.833,"lanoconazole, ketoconazole",0.266802734893431,0.0793549985932124,FALSE
+"H460","Pearson.est","TGF beta receptor inhibitor",0.25815,0.697,0.804,1075,0.852,"LY2109761, SB.525334, repsox, adaprev, D.4476, SB.431542",0.0947439512515487,0.0695604052332999,FALSE
+"H460","Pearson.est","thymidylate synthase inhibitor",-0.59503,-1.51,0.066,1312,0.396,"capecitabine, trifluridine, carmofur",1.18045606445813,0.402304814074488,FALSE
+"H460","Pearson.est","topoisomerase inhibitor",-0.31393,-0.807,0.688,960,0.909,"genz.644282, camptothecin, SN.38, licochalcone.a, TAS.103, rubitecan, amsacrine, mitoxantrone, voreloxin, idarubicin, amonafide, valrubicin",0.162411561764489,0.0414361167780325,FALSE
+"H460","Pearson.est","tubulin polymerization inhibitor",-0.61095,-1.53,0.0691,989,0.445,"podophyllotoxin, albendazole, dolastatin.10, vindesine, plinabulin, epothilone.d, BNC105, vinblastine, ABT.751, docetaxel, taltobulin, flubendazole, parbendazole, combretastatin.A.4, verubulin, KX2.391, epothilone.b, fosbretabulin",1.1605219526258,0.351639989019068,FALSE
+"H460","Pearson.est","tyrosine kinase inhibitor",-0.33414,-0.855,0.622,978,0.872,"AMG.208, BMS.599626, NVP.TAE226, tivantinib, AV.412, aminopurvalanol.a, UNC2250, sunitinib, tyrphostin.AG.99, CP.724714, mubritinib",0.206209615309181,0.0594835150674328,FALSE
+"H460","Pearson.est","VEGFR inhibitor",-0.43721,-1.08,0.356,1084,0.736,"nintedanib, vatalanib, golvatinib, TG.100572, linifanib, dovitinib, tivozanib, foretinib, KI.8751, MGCD.265, sunitinib, semaxanib, OSI.930, axitinib, ENMD.2076",0.448550002027125,0.133122185662501,FALSE
+"H460","Pearson.est","vitamin D receptor agonist",-0.46528,-1.16,0.298,1002,0.767,"calcitriol, alfacalcidol, doxercalciferol, tacalcitol, ercalcitriol",0.525783735923745,0.115204636051019,FALSE
+"H1299","Pearson.est","EGFR inhibitor",0.50186,1.29,0.196,430,0.65,"OSI.420, tyrphostin.AG.1478, erlotinib, gefitinib, BIBX.1382, WZ8040, icotinib, CP.724714, BIBU.1361, AZD8931, dacomitinib, osimertinib, pelitinib, canertinib, PD.153035, AST.1306, poziotinib, tyrphostin.AG.494, afatinib, BMS.690514, lapatinib, CGP.52411, ARRY.334543, XL.647, neratinib, WZ.3146, PD.168393",0.707743928643524,0.187086643357144,FALSE
+"H1299","Pearson.est","Abl kinase inhibitor",-0.54426,-1.41,0.114,973,0.368,"dasatinib, bafetinib, metatinib, nilotinib, flumatinib, GZD824, ponatinib",0.943095148663527,0.434152181326482,FALSE
+"H1299","Pearson.est","acetylcholine receptor agonist",-0.33247,-0.887,0.575,1192,0.681,"xanomeline, tremorine",0.24033215531037,0.166852888087215,FALSE
+"H1299","Pearson.est","acetylcholine receptor antagonist",0.28589,0.741,0.781,424,0.911,"darifenacin, diphemanil, dicycloverine",0.1073489661227,0.0404816230270017,FALSE
+"H1299","Pearson.est","adenosine receptor antagonist",0.85637,2.2,0,59,0.00751,"SCH.58261, CGS.15943, MRS.1220, PSB.1115",Inf,2.12436006299583,TRUE
+"H1299","Pearson.est","adrenergic receptor agonist",0.52866,1.37,0.137,408,0.707,"oxymetazoline, clenbuterol, lidamidine, metaraminol, methyldopa, isoxsuprine, A61603",0.863279432843593,0.150580586203101,FALSE
+"H1299","Pearson.est","adrenergic receptor antagonist",0.34974,0.873,0.59,127,1,"levobunolol, imiloxan, dronedarone, atenolol....",0.229147988357856,0,FALSE
+"H1299","Pearson.est","AKT inhibitor",0.49189,1.27,0.197,341,0.64,"CCT128930, uprosertib, GDC.0068, palomid.529, AZD5363",0.705533773838407,0.193820026016113,FALSE
+"H1299","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.40064,1,0.449,102,0.859,"NVP.TAE684, GW.788388",0.347753658996677,0.0660068361687577,FALSE
+"H1299","Pearson.est","androgen receptor antagonist",0.45692,1.16,0.283,363,0.795,"enzalutamide, cyproterone.acetate",0.54821356447571,0.0996328713435297,FALSE
+"H1299","Pearson.est","antioxidant",0.39206,1.02,0.423,487,0.853,"benfotiamine, taurine, chlorogenic.acid, mesna",0.373659632624958,0.069050968832477,FALSE
+"H1299","Pearson.est","AP inhibitor",-0.48103,-1.24,0.237,1432,0.466,"idronoxil",0.625251653989896,0.33161408331,FALSE
+"H1299","Pearson.est","ATPase inhibitor",-0.53703,-1.37,0.149,1135,0.369,"digitoxigenin, ouabain, thonzonium, k.strophanthidin, digoxin, oligomycin.a",0.826813731587726,0.43297363384094,FALSE
+"H1299","Pearson.est","Aurora kinase inhibitor",-0.35907,-0.903,0.54,1213,0.677,"CYC116, MK.5108, AMG900, aurora.a.inhibitor.i, CCT137690",0.267606240177031,0.169411331314856,FALSE
+"H1299","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.43403,-1.1,0.328,1198,0.572,"josamycin, valnemulin",0.484126156288321,0.242603971206976,FALSE
+"H1299","Pearson.est","bacterial DNA gyrase inhibitor",0.1921,0.491,0.982,340,1,"finafloxacin, trovafloxacin",0.00788851221305034,0,FALSE
+"H1299","Pearson.est","BCL inhibitor",-0.37014,-0.957,0.5,1329,0.634,"gossypol, ABT.737",0.301029995663981,0.197910742118267,FALSE
+"H1299","Pearson.est","Bcr.Abl kinase inhibitor",-0.5751,-1.48,0.0996,973,0.362,"dasatinib, bafetinib, metatinib, nilotinib, flumatinib, GZD824, ponatinib",1.0017406615763,0.441291429466834,FALSE
+"H1299","Pearson.est","benzodiazepine receptor agonist",0.49407,1.26,0.203,301,0.616,"gamma.aminobutyric.acid, lorazepam, nefiracetam, piperazine, eprinomectin, zaleplon",0.692503962086787,0.210419287835575,FALSE
+"H1299","Pearson.est","bromodomain inhibitor",-0.32005,-0.821,0.661,1068,0.719,"bromosporine, PFI.1",0.17979854051436,0.143271109617117,FALSE
+"H1299","Pearson.est","calcium channel blocker",-0.34313,-0.855,0.64,1438,0.71,"carboxyamidotriazole",0.193820026016113,0.148741651280925,FALSE
+"H1299","Pearson.est","CC chemokine receptor antagonist",-0.46219,-1.2,0.218,1416,0.475,"UNBS.5162",0.661543506395395,0.323306390375133,FALSE
+"H1299","Pearson.est","CDK inhibitor",0.40329,1.03,0.398,381,0.87,"indirubin, arcyriaflavin.a, alvocidib, JNJ.7706621, BMS.387032, kenpaullone, P276.00, AZD5438, TG.02",0.400116927926312,0.0604807473813815,FALSE
+"H1299","Pearson.est","CHK inhibitor",-0.31159,-0.821,0.68,449,0.719,"SCH.900776, CHIR.124, LY2603618, SB.218078, LY2606368, AZD7762, PF.477736",0.167491087293764,0.143271109617117,FALSE
+"H1299","Pearson.est","cyclooxygenase inhibitor",0.31872,0.803,0.691,184,0.938,"tryptanthrin, FK.3311, phenylbutazone, FR.122047, amfenac",0.160521952625802,0.0277971616209356,FALSE
+"H1299","Pearson.est","cytochrome P450 inhibitor",0.45151,1.14,0.295,222,0.747,"PF.4981517, morin, itraconazole",0.530177984021837,0.126679398184601,FALSE
+"H1299","Pearson.est","DNA alkylating agent",0.1915,0.488,0.994,179,0.985,"dacarbazine, ifosfamide",0.00261361560268669,0.00656376950238827,FALSE
+"H1299","Pearson.est","DNA inhibitor",0.29509,0.749,0.78,18,0.924,"busulfan, nithiamide",0.10790539730952,0.0343280287798933,FALSE
+"H1299","Pearson.est","DNA methyltransferase inhibitor",0.31622,0.82,0.672,37,0.935,"azacitidine",0.172630726946175,0.0291883891274822,FALSE
+"H1299","Pearson.est","DNA polymerase inhibitor",0.43087,1.1,0.329,15,0.794,"famciclovir",0.482804102050026,0.100179497572904,FALSE
+"H1299","Pearson.est","DNA synthesis inhibitor",0.26804,0.688,0.824,130,0.94,"altretamine, estramustine.phosphate",0.0840727883028842,0.0268721464003014,FALSE
+"H1299","Pearson.est","dopamine receptor antagonist",0.34915,0.908,0.524,417,0.987,"acetophenazine, ziprasidone, domperidone, remoxipride, oxiperomide, nemonapride, mesoridazine, sertindole, UH.232...., clebopride",0.280668713016273,0.00568284733036327,FALSE
+"H1299","Pearson.est","estrogen receptor agonist",-0.44971,-1.14,0.306,1137,0.538,"estrone, levonorgestrel",0.51427857351842,0.269217724333611,FALSE
+"H1299","Pearson.est","estrogen receptor antagonist",-0.60297,-1.58,0.0571,1042,0.33,"tamoxifen, toremifene, raloxifene",1.24336389175415,0.481486060122112,FALSE
+"H1299","Pearson.est","FGFR inhibitor",-0.59386,-1.57,0.0531,1298,0.305,"lenvatinib, nintedanib, dovitinib, erdafitinib, regorafenib",1.27490547891853,0.515700160653214,FALSE
+"H1299","Pearson.est","FLT3 inhibitor",-0.54511,-1.42,0.12,1203,0.382,"midostaurin, quizartinib, tyrphostin.AG.1296, TG.101348, dovitinib, ponatinib, sorafenib",0.920818753952375,0.417936637088291,FALSE
+"H1299","Pearson.est","glucocorticoid receptor agonist",-0.17553,-0.446,0.996,975,0.994,"beclomethasone.dipropionate, triamcinolone, fluorometholone, rimexolone, halobetasol.propionate, fluticasone.propionate, flumethasone.pivalate, prednisolone.acetate, deflazacort",0.00174066157630127,0.00261361560268669,FALSE
+"H1299","Pearson.est","glutamate receptor antagonist",0.43567,1.15,0.301,451,0.769,"diazooxonorleucine, latrepirdine, kynurenic.acid, JNJ.16259685, CPP, SIB.1757, felbamate",0.521433504406157,0.114073660198569,FALSE
+"H1299","Pearson.est","glycogen synthase kinase inhibitor",0.34114,0.871,0.589,106,0.993,"indirubin, CHIR.99021",0.229884705212898,0.00305075150461883,FALSE
+"H1299","Pearson.est","growth factor receptor inhibitor",0.3327,0.841,0.632,134,0.987,"GSK1904529A",0.199282921717615,0.00568284733036327,FALSE
+"H1299","Pearson.est","HCV inhibitor",-0.38825,-1.02,0.414,1447,0.58,"narlaprevir",0.382999658879101,0.236572006437063,FALSE
+"H1299","Pearson.est","HDAC inhibitor",0.53523,1.37,0.152,211,0.707,"tacedinaline, JNJ.26481585, nexturastat.a, romidepsin, panobinostat, pyroxamide, vorinostat, R306465",0.818156412055227,0.150580586203101,FALSE
+"H1299","Pearson.est","histamine receptor antagonist",0.28086,0.736,0.779,472,0.895,"terfenadine, famotidine, chloropyramine, ranitidine, levocetirizine, astemizole, zolantidine, tecastemizole, pheniramine, lafutidine",0.108462542327436,0.048176964684088,FALSE
+"H1299","Pearson.est","HMGCR inhibitor",-0.69071,-1.72,0.0312,996,0.276,"lovastatin, simvastatin, mevastatin, fluvastatin, atorvastatin, pitavastatin",1.50584540598156,0.559090917934782,FALSE
+"H1299","Pearson.est","HSP inhibitor",-0.27691,-0.702,0.814,923,0.862,"BIIB021, NMS.E973, PU.H71, alvespimycin, NVP.AUY922, ganetespib, SNX.2112",0.0893755951107988,0.0644927341752872,FALSE
+"H1299","Pearson.est","JAK inhibitor",0.21217,0.54,0.96,125,1,"CEP.33779, atiprimod",0.0177287669604316,0,FALSE
+"H1299","Pearson.est","KIT inhibitor",-0.57724,-1.49,0.0936,1203,0.386,"midostaurin, masitinib, lenvatinib, pazopanib, sorafenib, regorafenib",1.02872415126189,0.413412695328245,FALSE
+"H1299","Pearson.est","MDM inhibitor",0.64637,1.7,0.0236,506,0.465,"nutlin.3, CGM097, RITA, idasanutlin, serdemetan",1.62708799702989,0.332547047110046,FALSE
+"H1299","Pearson.est","MEK inhibitor",0.71696,1.85,0.00595,336,0.25,"BIX.02188, AS.703026, selumetinib, PD.0325901, cobimetinib, trametinib, PD.198306, MEK162, refametinib, Ro.4987655, PD.184352, TAK.733, AZD8330",2.22548303427145,0.602059991327962,FALSE
+"H1299","Pearson.est","MET inhibitor",-0.37292,-0.966,0.475,1406,0.641,"LY2801653",0.323306390375133,0.193141970481183,FALSE
+"H1299","Pearson.est","microtubule inhibitor",-0.5271,-1.35,0.169,1141,0.37,"podophyllotoxin, vinblastine, secnidazole, D.64131, cabazitaxel",0.772113295386326,0.431798275933005,FALSE
+"H1299","Pearson.est","mTOR inhibitor",0.20325,0.52,0.972,391,1,"PP242, PI.103, palomid.529, XL388, torin.2, WAY.600, LY303511, AZD8055, GSK2126458, PF.05212384",0.0123337350737254,0,FALSE
+"H1299","Pearson.est","NFkB pathway inhibitor",0.31021,0.793,0.655,460,0.876,"bindarit, IKK.2.inhibitor.V, betulinic.acid, parthenolide...., tyloxapol",0.183758700008217,0.0574958938319193,FALSE
+"H1299","Pearson.est","opioid receptor agonist",0.30766,0.799,0.688,360,0.917,"salvinorin.a, BW.180C",0.162411561764489,0.0376306643299789,FALSE
+"H1299","Pearson.est","p38 MAPK inhibitor",0.52106,1.33,0.158,421,0.667,"SB.239063, skepinone.l, TAK.715, SB.242235, CMPD.1",0.801342913045577,0.175874166083451,FALSE
+"H1299","Pearson.est","PARP inhibitor",0.30896,0.796,0.697,283,0.896,"PJ.34, endo.IWR.1",0.156767221901991,0.0476919903378748,FALSE
+"H1299","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.57721,-1.47,0.0961,1196,0.341,"linifanib, axitinib, masitinib, lenvatinib, crenolanib, nintedanib, dovitinib, pazopanib, ponatinib, sorafenib, regorafenib",1.01727661233145,0.467245621007502,FALSE
+"H1299","Pearson.est","phosphatase inhibitor",-0.4204,-1.06,0.359,1232,0.564,"GSK2830371, CID.5458317, bis.maltolato.oxovanadium.IV.",0.444905551421681,0.248720896016658,FALSE
+"H1299","Pearson.est","phosphodiesterase inhibitor",0.58881,1.54,0.0668,288,0.639,"cilostamide, zardaverine, GSK256066, anagrelide",1.17522353752445,0.1944991418416,FALSE
+"H1299","Pearson.est","PI3K inhibitor",0.25132,0.653,0.876,391,0.958,"pilaralisib, alpelisib, CH5132799, PI.103, idelalisib, PI.828, AZD6482, LY303511, TG.100713, GSK2126458, TG100.115, PF.05212384",0.0574958938319193,0.0186344909214556,FALSE
+"H1299","Pearson.est","PLK inhibitor",-0.80985,-2.07,0.0021,1167,0.0537,"rigosertib, HMN.214, GW.843682X, NMS.1286937, volasertib, GSK461364, BI.2536",2.67778070526608,1.27002571430044,TRUE
+"H1299","Pearson.est","potassium channel blocker",0.52573,1.36,0.163,145,0.662,"oleoylethanolamide, ibutilide",0.787812395596042,0.1791420105603,FALSE
+"H1299","Pearson.est","PPAR receptor agonist",0.50097,1.29,0.212,335,0.65,"oleoylethanolamide, S26948, clofibrate, pterostilbene",0.673664139071249,0.187086643357144,FALSE
+"H1299","Pearson.est","progesterone receptor agonist",0.31764,0.835,0.644,109,0.967,"norethindrone.acetate, dienogest",0.191114132640188,0.0145735259169983,FALSE
+"H1299","Pearson.est","proteasome inhibitor",-0.3975,-1.03,0.401,1345,0.586,"delanzomib",0.396855627379818,0.232102383981909,FALSE
+"H1299","Pearson.est","protein synthesis inhibitor",-0.35713,-0.929,0.531,1222,0.657,"bruceantin, puromycin, harringtonine, mercaptopurine, anguidine",0.274905478918531,0.182434630440219,FALSE
+"H1299","Pearson.est","protein tyrosine kinase inhibitor",-0.42631,-1.09,0.369,1140,0.563,"AV.412, tyrphostin.A9, rheochrysidin, mubritinib",0.43297363384094,0.249491605148654,FALSE
+"H1299","Pearson.est","RAF inhibitor",-0.48538,-1.28,0.192,1297,0.436,"RAF265, TAK.632, sorafenib, regorafenib",0.71669877129645,0.360513510731414,FALSE
+"H1299","Pearson.est","RET tyrosine kinase inhibitor",-0.63386,-1.6,0.0673,1421,0.35,"sorafenib, regorafenib",1.17198493577602,0.455931955649724,FALSE
+"H1299","Pearson.est","retinoid receptor agonist",0.32755,0.843,0.633,325,1,"adarotene, CD.437, AM.580, tamibarotene",0.198596289982645,0,FALSE
+"H1299","Pearson.est","ribonucleotide reductase inhibitor",-0.76235,-2,0.00204,1301,0.0579,"LY2334737, triapine, clofarabine, gemcitabine, pentostatin, cladribine",2.6903698325741,1.23732143627256,TRUE
+"H1299","Pearson.est","serotonin receptor agonist",0.63387,1.62,0.0419,129,0.547,"aripiprazole, ipsapirone",1.3777859770337,0.262012673666569,FALSE
+"H1299","Pearson.est","serotonin receptor antagonist",0.40655,1.04,0.375,347,0.89,"aripiprazole, ziprasidone, SB.228357, tropisetron, sertindole",0.425968732272281,0.0506099933550872,FALSE
+"H1299","Pearson.est","sodium channel blocker",0.32089,0.832,0.658,339,0.941,"lappaconite, benzethonium, A.803467, triamterene, ajmaline",0.181774106386044,0.0264103765727431,FALSE
+"H1299","Pearson.est","src inhibitor",0.37818,0.976,0.471,193,0.874,"PP.2, PP.1, saracatinib",0.326979092871104,0.058488567365597,FALSE
+"H1299","Pearson.est","sterol demethylase inhibitor",-0.55473,-1.4,0.136,1005,0.354,"posaconazole, ketoconazole, sulconazole, chlormidazole, lanoconazole",0.866461091629782,0.450996737974212,FALSE
+"H1299","Pearson.est","TGF beta receptor inhibitor",0.5658,1.45,0.104,228,0.779,"LY2109761, D.4476",0.98296666070122,0.108462542327436,FALSE
+"H1299","Pearson.est","thymidylate synthase inhibitor",-0.21988,-0.571,0.935,1253,0.969,"trifluridine",0.0291883891274822,0.0136762229492347,FALSE
+"H1299","Pearson.est","topoisomerase inhibitor",-0.71905,-1.81,0.00984,1176,0.194,"dexrazoxane, rubitecan, etoposide, topotecan, epirubicin, nemorubicin, amsacrine, exatecan.mesylate, SN.38, teniposide, voreloxin, doxorubicin, amonafide, daunorubicin, valrubicin, etoposide.phosphate, idarubicin, TAS.103, mitoxantrone",2.00700490156866,0.712198270069774,TRUE
+"H1299","Pearson.est","tubulin polymerization inhibitor",-0.6475,-1.67,0.0456,1009,0.292,"paclitaxel, nocodazole, plinabulin, oxibendazole, podophyllotoxin, ABT.751, CYT.997, KX2.391, parbendazole, vincristine, fenbendazole, BNC105, vinblastine, vindesine, verubulin, taltobulin, epothilone.b, dolastatin.10, flubendazole, mebendazole, docetaxel",1.34103515733556,0.534617148551582,FALSE
+"H1299","Pearson.est","tyrosine kinase inhibitor",-0.41944,-1.06,0.37,973,0.564,"dasatinib, bafetinib, sunitinib, aminopurvalanol.a, tyrphostin.AG.99, AV.412, cabozantinib, tyrphostin.A9, rheochrysidin, hypericin, mubritinib, sorafenib, regorafenib",0.431798275933005,0.248720896016658,FALSE
+"H1299","Pearson.est","VEGFR inhibitor",-0.4705,-1.22,0.233,1196,0.47,"linifanib, axitinib, TG.100572, RAF265, lenvatinib, nintedanib, dovitinib, golvatinib, pazopanib, tivozanib, foretinib, sorafenib, regorafenib",0.632644078973981,0.327902142064283,FALSE
+"H1299","Pearson.est","vitamin D receptor agonist",0.53526,1.41,0.11,225,0.788,"maxacalcitol, calcitriol, ercalcitriol, paricalcitol",0.958607314841775,0.103473782510445,FALSE
+"HCC44","Pearson.est","EGFR inhibitor",-0.12768,-0.329,1,853,1,"dacomitinib, AST.1306, canertinib, tucatinib, erlotinib, osimertinib, BIBX.1382, CP.724714, gefitinib, OSI.420, CUDC.101, FERb.033, BMS.690514, BMS.599626, WZ8040, CGP.52411, BIBU.1361, tyrphostin.AG.1478, tyrphostin.AG.494",0,0,FALSE
+"HCC44","Pearson.est","Abl kinase inhibitor",0.32323,0.85,0.621,394,0.975,"bafetinib, GZD824, flumatinib, ZM.306416, ponatinib, metatinib",0.20690839982342,0.0109953843014632,FALSE
+"HCC44","Pearson.est","acetylcholine receptor agonist",-0.4241,-1.08,0.362,846,0.727,"tremorine, nefiracetam, oxiracetam, nicotine",0.441291429466834,0.138465589140962,FALSE
+"HCC44","Pearson.est","acetylcholine receptor antagonist",0.68428,1.73,0.0193,426,0.553,"iododexetimide, hyoscyamine, diphemanil, darifenacin, methscopolamine",1.71444269099223,0.257274868695302,FALSE
+"HCC44","Pearson.est","adenosine receptor antagonist",-0.31109,-0.783,0.705,1370,0.977,"PSB.1115",0.151810883008601,0.0101054362812269,FALSE
+"HCC44","Pearson.est","adrenergic receptor agonist",0.29192,0.754,0.764,81,0.931,"xylazine, A61603",0.11690664142431,0.0310503190186574,FALSE
+"HCC44","Pearson.est","adrenergic receptor antagonist",-0.27937,-0.693,0.809,1339,0.998,"atipamezole, dronedarone, levobunolol, imiloxan",0.0920514783877277,0.000869458712628891,FALSE
+"HCC44","Pearson.est","AKT inhibitor",-0.49942,-1.28,0.227,1025,0.619,"GDC.0068, AZD5363, CCT128930, ONC201, uprosertib",0.643974142806877,0.208309350979882,FALSE
+"HCC44","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.44421,1.16,0.278,252,0.986,"AP26113, lorlatinib, NVP.TAE684, CEP.37440",0.555955204081924,0.0061230850587888,FALSE
+"HCC44","Pearson.est","androgen receptor antagonist",-0.3531,-0.911,0.572,1428,0.932,"RU.58841",0.242603971206976,0.0305840876460186,FALSE
+"HCC44","Pearson.est","antioxidant",-0.65149,-1.63,0.0536,1253,0.371,"chlorogenic.acid, benfotiamine, mesna",1.27083521030723,0.430626090384954,FALSE
+"HCC44","Pearson.est","AP inhibitor",-0.25485,-0.643,0.899,1097,0.977,"GDC.0152, birinapant",0.0462403082667712,0.0101054362812269,FALSE
+"HCC44","Pearson.est","ATPase inhibitor",-0.22186,-0.553,0.95,1158,1,"ouabain, digoxin, thonzonium",0.0222763947111523,0,FALSE
+"HCC44","Pearson.est","Aurora kinase inhibitor",-0.49035,-1.23,0.232,1211,0.63,"barasertib, PF.03814735, CCT129202, ENMD.2076, alisertib, KW.2449, MK.8745, GSK1070916, MLN.8054",0.6345120151091,0.200659450546418,FALSE
+"HCC44","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.32309,0.817,0.676,67,0.97,"dirithromycin, josamycin",0.170053304058364,0.0132282657337552,FALSE
+"HCC44","Pearson.est","bacterial DNA gyrase inhibitor",-0.50939,-1.3,0.168,1389,0.684,"novobiocin, finafloxacin",0.774690718274137,0.164943898279884,FALSE
+"HCC44","Pearson.est","BCL inhibitor",-0.36632,-0.934,0.524,1122,0.921,"TW.37, HA14.1, venetoclax, oridonin",0.280668713016273,0.0357403698031511,FALSE
+"HCC44","Pearson.est","Bcr.Abl kinase inhibitor",0.37437,0.958,0.494,469,0.885,"bafetinib, GZD824, flumatinib, ponatinib, metatinib, bosutinib",0.306273051076353,0.0530567293021746,FALSE
+"HCC44","Pearson.est","benzodiazepine receptor agonist",0.29612,0.765,0.748,332,0.941,"indiplon, bentazepam, gamma.aminobutyric.acid, piperazine, CL.218872",0.126098402135539,0.0264103765727431,FALSE
+"HCC44","Pearson.est","bromodomain inhibitor",0.41894,1.07,0.35,60,0.895,"PFI.1",0.455931955649724,0.048176964684088,FALSE
+"HCC44","Pearson.est","calcium channel blocker",-0.34739,-0.889,0.555,1297,0.906,"mibefradil, SR.33805, cinnarazine",0.255707016877324,0.0428718023231869,FALSE
+"HCC44","Pearson.est","CC chemokine receptor antagonist",0.39852,1.03,0.412,125,0.942,"UNBS.5162, MK.0812",0.385102783966865,0.0259490972071227,FALSE
+"HCC44","Pearson.est","CDK inhibitor",-0.57078,-1.45,0.12,1036,0.714,"P276.00, abemaciclib, JNJ.7706621, indisulam, BMS.265246, R547, kenpaullone, indirubin, alvocidib, TG.02, palbociclib, PHA.793887, ribociclib, AZD5438",0.920818753952375,0.146301788223826,FALSE
+"HCC44","Pearson.est","CHK inhibitor",0.32205,0.819,0.667,439,1,"PF.477736, LY2606368, SB.218078",0.175874166083451,0,FALSE
+"HCC44","Pearson.est","cyclooxygenase inhibitor",0.25544,0.661,0.859,354,0.979,"naproxen, AM.404, FK.3311, tepoxalin, metoxibutropate, acetylsalicylsalicylic.acid, pterostilbene, ramifenazone, phenazone",0.0660068361687577,0.00921730819686218,FALSE
+"HCC44","Pearson.est","cytochrome P450 inhibitor",0.46516,1.17,0.276,409,1,"metyrapone, eplerenone, morin, cobicistat, clotrimazole",0.559090917934782,0,FALSE
+"HCC44","Pearson.est","DNA alkylating agent",0.20514,0.515,0.954,455,0.998,"dianhydrogalactitol, mitomycin.c, cyclophosphamide, streptozotocin, dacarbazine, satraplatin",0.0204516252959049,0.000869458712628891,FALSE
+"HCC44","Pearson.est","DNA inhibitor",-0.31349,-0.796,0.673,953,1,"metronidazole, sangivamycin, valrubicin, carboplatin, nithiamide, nimorazole, carmustine, busulfan",0.171984935776023,0,FALSE
+"HCC44","Pearson.est","DNA methyltransferase inhibitor",-0.5399,-1.38,0.132,1380,0.807,"decitabine, azacitidine",0.87942606879415,0.0931264652779296,FALSE
+"HCC44","Pearson.est","DNA polymerase inhibitor",-0.50278,-1.25,0.234,1041,0.635,"adefovir.dipivoxil, cidofovir, idoxuridine, foscarnet, trifluridine",0.630784142589857,0.197226274708024,FALSE
+"HCC44","Pearson.est","DNA synthesis inhibitor",0.28054,0.703,0.821,329,0.979,"estramustine.phosphate, nelarabine, artesunate, mitomycin.c",0.0856568428805592,0.00921730819686218,FALSE
+"HCC44","Pearson.est","dopamine receptor antagonist",-0.52503,-1.31,0.187,1141,0.728,"UH.232...., remoxipride, oxiperomide, domperidone, clebopride, acetophenazine, ziprasidone, mesoridazine",0.728158393463501,0.137868620686963,FALSE
+"HCC44","Pearson.est","estrogen receptor agonist",0.45284,1.14,0.315,155,0.963,"levonorgestrel, estradiol.cypionate",0.501689446210399,0.0163737128754655,FALSE
+"HCC44","Pearson.est","estrogen receptor antagonist",0.70856,1.8,0.0062,140,0.701,"toremifene, raloxifene, fulvestrant",2.20760831050175,0.154281982033341,FALSE
+"HCC44","Pearson.est","FGFR inhibitor",0.64474,1.66,0.0385,346,0.331,"erdafitinib, lenvatinib, AZD4547, regorafenib, orantinib, dovitinib",1.4145392704915,0.480172006224281,FALSE
+"HCC44","Pearson.est","FLT3 inhibitor",-0.30402,-0.778,0.735,1231,0.954,"tandutinib, TG.02, ENMD.2076, KW.2449, pacritinib",0.133712660915805,0.0204516252959049,FALSE
+"HCC44","Pearson.est","glucocorticoid receptor agonist",0.22616,0.585,0.925,356,0.98,"fluorometholone, deflazacort, triamcinolone.acetonide, clobetasol.propionate, betamethasone, flumethasone.pivalate, fluticasone.propionate, prednisolone",0.0338582672609674,0.00877392430750515,FALSE
+"HCC44","Pearson.est","glutamate receptor antagonist",0.37305,0.974,0.473,287,0.931,"LY456236, kynurenic.acid, tiletamine, MTPG, CGP.37849",0.325138859262188,0.0310503190186574,FALSE
+"HCC44","Pearson.est","glycogen synthase kinase inhibitor",-0.46347,-1.17,0.285,1205,0.596,"tideglusib, kenpaullone, indirubin, LY2090314",0.54515513999149,0.224753740259764,FALSE
+"HCC44","Pearson.est","growth factor receptor inhibitor",-0.29563,-0.726,0.779,426,1,"GW.441756, PHA.848125, danusertib, AZD3463, lestaurtinib, GSK1838705A, GSK1904529A",0.108462542327436,0,FALSE
+"HCC44","Pearson.est","HCV inhibitor",-0.48737,-1.22,0.234,1217,0.609,"daclatasvir, narlaprevir",0.630784142589857,0.215382707367125,FALSE
+"HCC44","Pearson.est","HDAC inhibitor",-0.48037,-1.2,0.242,1113,0.609,"belinostat, AR.42, RGFP966, panobinostat, tacedinaline, PCI.24781, givinostat, vorinostat, pyroxamide, JNJ.26481585, romidepsin, R306465",0.616184634019569,0.215382707367125,FALSE
+"HCC44","Pearson.est","histamine receptor antagonist",0.32467,0.816,0.674,538,0.94,"chloropyramine, tiotidine, ebastine, ICI.162846, BF2.649, zolantidine, lafutidine, astemizole, tecastemizole, cimetidine, nizatidine, famotidine, cyproheptadine",0.17134010346468,0.0268721464003014,FALSE
+"HCC44","Pearson.est","HMGCR inhibitor",0.6515,1.64,0.0518,279,0.304,"pitavastatin, mevastatin, lovastatin",1.28567024025477,0.517126416391246,FALSE
+"HCC44","Pearson.est","HSP inhibitor",-0.52358,-1.35,0.149,959,0.701,"KW.2478, ganetespib, VER.49009, PU.H71, tanespimycin, SNX.2112, SNX.5422, XL888, NVP.AUY922, BIIB021",0.826813731587726,0.154281982033341,FALSE
+"HCC44","Pearson.est","JAK inhibitor",-0.24431,-0.627,0.893,1032,0.967,"AZ960, tozasertib, WHI.P154, TG.02, pacritinib, filgotinib",0.0491485411114536,0.0145735259169983,FALSE
+"HCC44","Pearson.est","KIT inhibitor",-0.34353,-0.847,0.667,1231,0.957,"tandutinib, imatinib, KI.8751, OSI.930",0.175874166083451,0.0190880622231565,FALSE
+"HCC44","Pearson.est","MDM inhibitor",-0.75386,-1.93,0,1374,0.0717,"CGM097, nutlin.3, idasanutlin",Inf,1.1444808443322,TRUE
+"HCC44","Pearson.est","MEK inhibitor",-0.78085,-2.01,0.00762,1301,0.0507,"PD.198306, selumetinib, PD.184352, PD.318088, MEK162, refametinib, Ro.4987655, AS.703026, trametinib, cobimetinib, TAK.733, AZD8330, PD.0325901",2.1180450286604,1.29499204066666,TRUE
+"HCC44","Pearson.est","MET inhibitor",0.33722,0.868,0.607,374,1,"PHA.665752, LY2801653, NVP.BVU972",0.216811308924742,0,FALSE
+"HCC44","Pearson.est","microtubule inhibitor",0.41659,1.09,0.336,239,0.9,"estramustine.phosphate, colchicine, D.64131, cabazitaxel",0.473660722610156,0.0457574905606751,FALSE
+"HCC44","Pearson.est","mTOR inhibitor",-0.2677,-0.68,0.847,899,0.987,"NVP.BEZ235, palomid.529, everolimus, sirolimus, AZD8055, temsirolimus, ku.0063794, AZD2014, torin.2, OSI.027, voxtalisib, WAY.600, LY303511, GSK2126458, PP242, XL388",0.0721165896692931,0.00568284733036327,FALSE
+"HCC44","Pearson.est","NFkB pathway inhibitor",0.37746,0.966,0.46,207,0.906,"BAY.11.7082, tyloxapol, bindarit, EVP4593",0.337242168318426,0.0428718023231869,FALSE
+"HCC44","Pearson.est","opioid receptor agonist",-0.63294,-1.64,0.0514,1378,0.44,"salvinorin.a, cebranopadol",1.28903688100472,0.356547323513813,FALSE
+"HCC44","Pearson.est","p38 MAPK inhibitor",0.3299,0.859,0.631,298,0.994,"SB.242235, VX.702, SB.239063",0.199970640755866,0.00261361560268669,FALSE
+"HCC44","Pearson.est","PARP inhibitor",-0.41041,-1.02,0.392,1094,0.812,"niraparib, olaparib, talazoparib",0.406713932979543,0.0904439707588247,FALSE
+"HCC44","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",-0.25648,-0.65,0.875,1226,0.996,"CP.673451, tandutinib, imatinib, SU014813, KI.8751",0.0579919469776868,0.00174066157630127,FALSE
+"HCC44","Pearson.est","phosphatase inhibitor",0.42915,1.09,0.325,401,0.9,"BVT.948, GSK2830371, AS.1949490, CID.5458317",0.488116639021126,0.0457574905606751,FALSE
+"HCC44","Pearson.est","phosphodiesterase inhibitor",0.29938,0.765,0.742,312,0.941,"GSK256066, enoximone, trequinsin",0.129596094720973,0.0264103765727431,FALSE
+"HCC44","Pearson.est","PI3K inhibitor",-0.289,-0.712,0.81,1239,1,"alpelisib, LY303511, GSK2126458, TG.100713, CUDC.907, CH5132799",0.0915149811213502,0,FALSE
+"HCC44","Pearson.est","PLK inhibitor",0.59709,1.54,0.0646,75,0.431,"GSK461364, BI.2536",1.18976748200492,0.365522729839268,FALSE
+"HCC44","Pearson.est","potassium channel blocker",-0.54319,-1.37,0.138,1195,0.73,"meglitinide, oleoylethanolamide, ML133",0.860120913598763,0.136677139879544,FALSE
+"HCC44","Pearson.est","PPAR receptor agonist",0.31058,0.778,0.742,320,0.979,"GW.501516, pterostilbene, clofibrate",0.129596094720973,0.00921730819686218,FALSE
+"HCC44","Pearson.est","progesterone receptor agonist",0.53725,1.37,0.145,248,0.745,"nomegestrol.acetate, levonorgestrel, norgestrel, norethindrone.acetate",0.838631997765025,0.127843727251707,FALSE
+"HCC44","Pearson.est","proteasome inhibitor",-0.37258,-0.941,0.485,1051,0.947,"ixazomib, bortezomib, ixazomib.citrate, MG.132",0.314258261397736,0.0236500209967266,FALSE
+"HCC44","Pearson.est","protein synthesis inhibitor",0.39507,1.01,0.411,148,0.94,"clofoctol, mercaptopurine, anguidine, puromycin, clindamycin.phosphate, homoharringtonine",0.386158178123931,0.0268721464003014,FALSE
+"HCC44","Pearson.est","protein tyrosine kinase inhibitor",0.43151,1.1,0.35,206,1,"rheochrysidin, PP.121, tyrphostin.A9",0.455931955649724,0,FALSE
+"HCC44","Pearson.est","RAF inhibitor",-0.30781,-0.786,0.715,1160,1,"SB.590885, AZ.628, dabrafenib",0.145693958198919,0,FALSE
+"HCC44","Pearson.est","RET tyrosine kinase inhibitor",0.26699,0.675,0.842,1063,0.989,"regorafenib, vandetanib, cabozantinib, sorafenib, apatinib, sunitinib",0.0746879085003505,0.0048037084028206,FALSE
+"HCC44","Pearson.est","retinoid receptor agonist",0.39427,1,0.424,301,0.916,"fenretinide, AM.580, LE.135, bexarotene",0.372634143407267,0.0381045263321496,FALSE
+"HCC44","Pearson.est","ribonucleotide reductase inhibitor",0.64914,1.66,0.0429,337,0.331,"pentostatin, clofarabine, LY2334737, cladribine, fludarabine, gemcitabine, hydroxyurea",1.36754270781528,0.480172006224281,FALSE
+"HCC44","Pearson.est","serotonin receptor agonist",-0.81222,-2.09,0,1228,0.0473,"SR.57227A, ipsapirone, aripiprazole",Inf,1.32513885926219,TRUE
+"HCC44","Pearson.est","serotonin receptor antagonist",-0.50938,-1.29,0.2,1406,0.649,"ziprasidone, aripiprazole",0.698970004336019,0.187755303199631,FALSE
+"HCC44","Pearson.est","sodium channel blocker",0.46183,1.19,0.266,36,1,"cibenzoline, oxcarbazepine",0.575118363368933,0,FALSE
+"HCC44","Pearson.est","src inhibitor",0.49423,1.28,0.183,469,0.907,"PP.1, ZM.306416, TG.100572, KX2.391, saracatinib, bosutinib",0.737548910269571,0.0423927129399047,FALSE
+"HCC44","Pearson.est","sterol demethylase inhibitor",0.65572,1.68,0.0362,447,0.49,"lanoconazole, ketoconazole, posaconazole, terconazole, chlormidazole",1.44129142946683,0.309803919971486,FALSE
+"HCC44","Pearson.est","TGF beta receptor inhibitor",-0.34698,-0.904,0.587,920,0.91,"LY2109761, SB.431542, repsox, D.4476",0.231361898752386,0.0409586076789064,FALSE
+"HCC44","Pearson.est","thymidylate synthase inhibitor",-0.47431,-1.19,0.276,1196,0.593,"capecitabine, raltitrexed, carmofur, trifluridine",0.559090917934782,0.226945306635737,FALSE
+"HCC44","Pearson.est","topoisomerase inhibitor",0.24928,0.641,0.88,167,0.977,"dexrazoxane, licochalcone.a, mitoxantrone, etoposide",0.0555173278498314,0.0101054362812269,FALSE
+"HCC44","Pearson.est","tubulin polymerization inhibitor",0.18476,0.462,0.996,486,0.99,"CYT.997, dolastatin.10, ABT.751, vincristine, oxibendazole, mebendazole, nocodazole, KX2.391, paclitaxel, fenbendazole, indibulin, epothilone.d",0.00174066157630127,0.00436480540245009,FALSE
+"HCC44","Pearson.est","tyrosine kinase inhibitor",0.23085,0.585,0.951,206,0.98,"rheochrysidin, bafetinib, PP.121, tyrphostin.A9",0.0218194830625861,0.00877392430750515,FALSE
+"HCC44","Pearson.est","VEGFR inhibitor",-0.17543,-0.444,0.996,1255,1,"ENMD.2076, SU014813, KI.8751, MGCD.265, OSI.930",0.00174066157630127,0,FALSE
+"HCC44","Pearson.est","vitamin D receptor agonist",0.34167,0.865,0.577,327,1,"doxercalciferol, maxacalcitol, paricalcitol",0.238824186844269,0,FALSE
+"A549","Pearson.est","EGFR inhibitor",-0.21155,-0.549,0.946,1147,0.957,"CNX.2006, salvianolic.acid.B, CP.724714, PD.168393, lapatinib, CGP.52411, BIBU.1361, WZ8040, WZ.4002",0.0241088635982073,0.0190880622231565,FALSE
+"A549","Pearson.est","Abl kinase inhibitor",0.2773,0.73,0.805,209,1,"bafetinib, flumatinib, GZD824",0.0942041196321315,0,FALSE
+"A549","Pearson.est","acetylcholine receptor agonist",-0.26144,-0.692,0.826,377,0.932,"nefiracetam, pilocarpine, xanomeline, nicotine, tremorine, oxiracetam",0.0830199526796178,0.0305840876460186,FALSE
+"A549","Pearson.est","acetylcholine receptor antagonist",0.71882,1.88,0.00781,298,0.428,"iododexetimide, diphemanil, hyoscyamine, methscopolamine, darifenacin",2.1073489661227,0.368556230986828,FALSE
+"A549","Pearson.est","adenosine receptor antagonist",0.23437,0.62,0.899,477,1,"CGS.15943, MRS.1220, SCH.58261",0.0462403082667712,0,FALSE
+"A549","Pearson.est","adrenergic receptor agonist",0.45738,1.18,0.274,168,1,"methyldopa, xylazine, A61603, ritodrine",0.562249437179612,0,FALSE
+"A549","Pearson.est","adrenergic receptor antagonist",0.39377,1.01,0.41,231,0.958,"idazoxan, metoprolol, atenolol...., prazosin, RS.17053, practolol",0.387216143280265,0.0186344909214556,FALSE
+"A549","Pearson.est","AKT inhibitor",-0.43911,-1.15,0.291,1341,0.61,"AZD5363, AT7867",0.536107011014093,0.214670164989233,FALSE
+"A549","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.3773,0.991,0.444,271,0.919,"lorlatinib, CEP.37440, NVP.TAE684, AP26113",0.35261702988538,0.0366844886138887,FALSE
+"A549","Pearson.est","androgen receptor antagonist",0.42302,1.11,0.315,323,1,"enzalutamide, cyproterone.acetate, flutamide",0.501689446210399,0,FALSE
+"A549","Pearson.est","antioxidant",-0.67242,-1.75,0.0316,1225,0.288,"trolox, rutin, mesna, chlorogenic.acid",1.5003129173816,0.540607512240769,FALSE
+"A549","Pearson.est","AP inhibitor",0.25589,0.69,0.822,1079,1,"tanshinone.i, embelin, LCL.161, GDC.0152, idronoxil, birinapant",0.0851281824599496,0,FALSE
+"A549","Pearson.est","ATPase inhibitor",0.43003,1.12,0.316,113,1,"k.strophanthidin, evodiamine",0.500312917381596,0,FALSE
+"A549","Pearson.est","Aurora kinase inhibitor",-0.4402,-1.14,0.326,1031,0.593,"CCT137690, MK.5108, CCT129202, PHA.680632, CYC116, hesperadin, AMG900, MLN.8054, GSK1070916, KW.2449, PF.03814735",0.486782399932061,0.226945306635737,FALSE
+"A549","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.42231,-1.12,0.314,1323,0.595,"azalomycin.b, valnemulin, tedizolid, radezolid",0.503070351926785,0.22548303427145,FALSE
+"A549","Pearson.est","bacterial DNA gyrase inhibitor",0.39349,1.02,0.417,304,1,"norfloxacin, sparfloxacin, sarafloxacin, lomefloxacin",0.379863945026242,0,FALSE
+"A549","Pearson.est","BCL inhibitor",-0.41521,-1.07,0.369,1236,0.618,"TW.37, venetoclax",0.43297363384094,0.209011524911184,FALSE
+"A549","Pearson.est","Bcr.Abl kinase inhibitor",0.39623,1.04,0.402,209,1,"bafetinib, flumatinib, GZD824",0.39577394691553,0,FALSE
+"A549","Pearson.est","benzodiazepine receptor agonist",0.38078,0.998,0.458,289,0.943,"indiplon, gamma.aminobutyric.acid, CL.218872, bentazepam, temazepam, piperazine",0.339134521996131,0.0254883072626717,FALSE
+"A549","Pearson.est","bromodomain inhibitor",0.38627,1.01,0.43,891,0.958,"I.BET151, JQ1...., PFI.1, bromosporine, I.BET.762, OTX015",0.366531544420413,0.0186344909214556,FALSE
+"A549","Pearson.est","calcium channel blocker",0.31788,0.825,0.68,275,0.994,"SKF.96365, fendiline, penfluridol",0.167491087293764,0.00261361560268669,FALSE
+"A549","Pearson.est","CC chemokine receptor antagonist",-0.26654,-0.705,0.824,1232,0.944,"ZK811752, navarixin",0.0840727883028842,0.025028005701931,FALSE
+"A549","Pearson.est","CDK inhibitor",-0.43057,-1.16,0.275,961,0.673,"kenpaullone, PHA.848125, aminopurvalanol.a, indirubin, palbociclib, ribociclib, NU6027, R547, PHA.793887, AZD5438, BMS.265246",0.560667306169737,0.171984935776023,FALSE
+"A549","Pearson.est","CHK inhibitor",0.31059,0.799,0.68,311,1,"PF.477736, LY2606368",0.167491087293764,0,FALSE
+"A549","Pearson.est","cyclooxygenase inhibitor",0.27019,0.701,0.812,252,1,"naproxen, pterostilbene, FK.3311, phenylbutazone, phenazone",0.0904439707588247,0,FALSE
+"A549","Pearson.est","cytochrome P450 inhibitor",0.69324,1.83,0.0157,235,0.313,"morin, itraconazole, metyrapone, clotrimazole",1.80410034759077,0.504455662453552,FALSE
+"A549","Pearson.est","DNA alkylating agent",-0.46678,-1.25,0.207,1249,0.553,"cyclophosphamide, TH.302, mitomycin.c, carmustine, streptozotocin, carboplatin",0.684029654543082,0.257274868695302,FALSE
+"A549","Pearson.est","DNA inhibitor",-0.50283,-1.32,0.182,1306,0.564,"teroxirone, carmustine, nimorazole, valrubicin, carboplatin",0.739928612014925,0.248720896016658,FALSE
+"A549","Pearson.est","DNA methyltransferase inhibitor",-0.36158,-0.955,0.492,1101,0.676,"azacitidine, disulfiram, decitabine",0.30803489723264,0.170053304058364,FALSE
+"A549","Pearson.est","DNA polymerase inhibitor",0.34492,0.921,0.536,266,0.894,"famciclovir, cephalomannine",0.27083521030723,0.0486624812040823,FALSE
+"A549","Pearson.est","DNA synthesis inhibitor",-0.48177,-1.26,0.213,1191,0.626,"azodicarbonamide, enocitabine, mitomycin.c, cyclocytidine, anisomycin, floxuridine",0.671620396561262,0.20342566678957,FALSE
+"A549","Pearson.est","dopamine receptor antagonist",-0.22482,-0.584,0.933,1074,0.96,"UH.232...., remoxipride, acetophenazine, mesoridazine, amisulpride, thioproperazine, oxiperomide",0.0301183562535,0.0177287669604316,FALSE
+"A549","Pearson.est","estrogen receptor agonist",-0.39978,-1.02,0.407,968,0.645,"estradiol, ethinyl.estradiol, levonorgestrel, PPT",0.39040559077478,0.190440285364732,FALSE
+"A549","Pearson.est","estrogen receptor antagonist",0.58059,1.52,0.0693,199,0.927,"toremifene, fulvestrant, tamoxifen",1.15926676538819,0.0329202658555029,FALSE
+"A549","Pearson.est","FGFR inhibitor",0.56175,1.47,0.0959,299,0.907,"erdafitinib, lenvatinib, orantinib, dovitinib, lucitanib",1.01818139282934,0.0423927129399047,FALSE
+"A549","Pearson.est","FLT3 inhibitor",0.26289,0.701,0.836,319,1,"gilteritinib, tyrphostin.AG.1296, dovitinib, sorafenib, tandutinib",0.0777937225609836,0,FALSE
+"A549","Pearson.est","glucocorticoid receptor agonist",-0.5263,-1.37,0.153,1157,0.655,"prednisolone.acetate, beclomethasone.dipropionate, halobetasol.propionate, rimexolone, prednisolone.hemisuccinate, methylprednisolone, dexamethasone.acetate, desonide, prednisolone, ciclesonide, fluocinolone.acetonide, fludroxycortide",0.815308569182401,0.183758700008217,FALSE
+"A549","Pearson.est","glutamate receptor antagonist",0.42371,1.1,0.348,189,1,"kynurenic.acid, JNJ.16259685, LY456236, felbamate",0.458420756053419,0,FALSE
+"A549","Pearson.est","glycogen synthase kinase inhibitor",-0.24308,-0.641,0.912,961,0.963,"kenpaullone, tideglusib, LY2090314, indirubin, AZD2858",0.0400051616715838,0.0163737128754655,FALSE
+"A549","Pearson.est","growth factor receptor inhibitor",-0.46656,-1.25,0.227,1000,0.553,"PHA.848125, GSK1838705A, AZD3463",0.643974142806877,0.257274868695302,FALSE
+"A549","Pearson.est","HCV inhibitor",-0.50051,-1.32,0.165,1446,0.564,"narlaprevir",0.782516055786094,0.248720896016658,FALSE
+"A549","Pearson.est","HDAC inhibitor",-0.43884,-1.15,0.297,920,0.61,"dacinostat, R306465, ACY.1215, AR.42, RG2833, panobinostat, trichostatin.a, RGFP966, chidamide, PCI.24781, entinostat, romidepsin, JNJ.26481585, givinostat",0.527243550682788,0.214670164989233,FALSE
+"A549","Pearson.est","histamine receptor antagonist",0.3834,0.986,0.461,294,0.856,"chloropyramine, famotidine, lafutidine, ebastine, astemizole, tiotidine",0.336299074610352,0.0675262353228468,FALSE
+"A549","Pearson.est","HMGCR inhibitor",-0.31907,-0.848,0.627,981,0.834,"simvastatin, fluvastatin, pitavastatin",0.202732459169284,0.0788339493622613,FALSE
+"A549","Pearson.est","HSP inhibitor",-0.56818,-1.51,0.0842,1245,0.497,"SNX.2112, ganetespib, NVP.AUY922, VER.49009, BIIB021, PU.H71, tanespimycin",1.07468790850035,0.303643611266668,FALSE
+"A549","Pearson.est","JAK inhibitor",-0.41421,-1.09,0.337,1258,0.614,"pacritinib, WHI.P154, AZ960, filgotinib",0.472370099128661,0.211831628858832,FALSE
+"A549","Pearson.est","KIT inhibitor",0.36655,0.933,0.516,93,0.901,"cediranib, lenvatinib, pazopanib",0.287350298372789,0.045275209020937,FALSE
+"A549","Pearson.est","MDM inhibitor",-0.70315,-1.87,0.0201,1137,0.376,"nutlin.3, CGM097, RITA, idasanutlin",1.69680394257951,0.424812155072339,FALSE
+"A549","Pearson.est","MEK inhibitor",-0.63047,-1.63,0.0427,1332,0.433,"cobimetinib, MEK162, trametinib, PD.0325901, selumetinib, TAK.733, Ro.4987655, AS.703026, PD.318088, refametinib, PD.184352, AZD8330",1.36957212497498,0.363512103646635,FALSE
+"A549","Pearson.est","MET inhibitor",-0.53736,-1.4,0.13,1218,0.669,"PF.04217903",0.886056647693163,0.174573882232177,FALSE
+"A549","Pearson.est","microtubule inhibitor",0.29374,0.765,0.734,212,1,"colchicine, estramustine.phosphate",0.134303940083929,0,FALSE
+"A549","Pearson.est","mTOR inhibitor",-0.72148,-1.86,0.012,1117,0.202,"voxtalisib, PI.103, WYE.354, deforolimus, LY3023414, LY303511, AZD2014, WAY.600, AZD8055, temsirolimus, MLN0128, PP242, GDC.0980, ku.0063794, XL388, torin.1, SB.2343, NVP.BEZ235, sirolimus, everolimus, GSK2126458",1.92081875395238,0.694648630553376,TRUE
+"A549","Pearson.est","NFkB pathway inhibitor",0.39684,1.03,0.411,167,1,"parthenolide...., bindarit, tyloxapol",0.386158178123931,0,FALSE
+"A549","Pearson.est","opioid receptor agonist",-0.29405,-0.757,0.752,1050,0.926,"BW.180C, cebranopadol, salvinorin.a",0.123782159408358,0.0333890133180656,FALSE
+"A549","Pearson.est","p38 MAPK inhibitor",0.61473,1.58,0.0572,205,0.949,"TAK.715, SB.239063, SB.242235",1.24260397120698,0.0227337875727074,FALSE
+"A549","Pearson.est","PARP inhibitor",-0.2455,-0.632,0.893,1128,0.944,"olaparib, endo.IWR.1, talazoparib",0.0491485411114536,0.025028005701931,FALSE
+"A549","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.22504,0.594,0.933,319,0.988,"lenvatinib, pazopanib, orantinib, dovitinib, sorafenib, tandutinib",0.0301183562535,0.00524305541237188,FALSE
+"A549","Pearson.est","phosphatase inhibitor",0.36346,0.951,0.518,443,0.897,"BVT.948, GSK2830371, AS.1949490, CID.5458317, mycophenolate.mofetil, alexidine",0.285670240254767,0.0472075569559079,FALSE
+"A549","Pearson.est","phosphodiesterase inhibitor",0.29244,0.769,0.735,29,1,"enoximone",0.133712660915805,0,FALSE
+"A549","Pearson.est","PI3K inhibitor",-0.59205,-1.59,0.0471,1083,0.421,"ZSTK.474, voxtalisib, PI.103, CUDC.907, LY3023414, LY303511, alpelisib, TG.100713, pilaralisib, PI3K.IN.2, GDC.0941, taselisib, GDC.0980, CH5132799, YM.201636, SB.2343, NVP.BEZ235, GSK2126458",1.3269790928711,0.375717904164332,FALSE
+"A549","Pearson.est","PLK inhibitor",-0.3731,-0.99,0.439,1023,0.668,"NMS.1286937, HMN.214, rigosertib",0.357535479757879,0.175223537524454,FALSE
+"A549","Pearson.est","potassium channel blocker",0.40471,1.06,0.372,19,1,"dofetilide",0.429457060118102,0,FALSE
+"A549","Pearson.est","PPAR receptor agonist",0.46152,1.22,0.231,225,1,"pterostilbene, S26948, GW.501516",0.636388020107856,0,FALSE
+"A549","Pearson.est","progesterone receptor agonist",0.18346,0.486,0.986,1184,1,"nomegestrol.acetate, norethindrone.acetate, dienogest, norethindrone, norgestrel, melengestrol.acetate, danazol, levonorgestrel, tanaproget",0.0061230850587888,0,FALSE
+"A549","Pearson.est","proteasome inhibitor",0.48687,1.28,0.204,480,1,"oprozomib, carfilzomib, ONX.0914, bortezomib, MG.132",0.690369832574101,0,FALSE
+"A549","Pearson.est","protein synthesis inhibitor",-0.28509,-0.743,0.774,955,0.916,"methacycline, azomycin..2.nitroimidazole., emetine, anguidine, tedizolid.phosphate, brefeldin.a, mercaptopurine, cycloheximide, thiostrepton",0.111259039317107,0.0381045263321496,FALSE
+"A549","Pearson.est","protein tyrosine kinase inhibitor",0.25919,0.669,0.868,315,1,"rheochrysidin, PP.121, tyrphostin.A9",0.0614802748235081,0,FALSE
+"A549","Pearson.est","RAF inhibitor",0.42989,1.13,0.288,574,1,"GDC.0879, PLX.4720, vemurafenib, sorafenib, SB.590885, regorafenib, LGX818, TAK.632, RAF265",0.540607512240769,0,FALSE
+"A549","Pearson.est","RET tyrosine kinase inhibitor",0.35931,0.908,0.545,415,0.86,"sorafenib, apatinib, regorafenib",0.263603497723358,0.0655015487564323,FALSE
+"A549","Pearson.est","retinoid receptor agonist",0.46829,1.22,0.223,296,1,"adapalene, fenretinide, AM.580, tamibarotene",0.651695136951839,0,FALSE
+"A549","Pearson.est","ribonucleotide reductase inhibitor",0.27399,0.712,0.79,1054,1,"pentostatin, cytarabine, hydroxyurea, fludarabine.phosphate, LY2334737, cladribine, clofarabine, fludarabine, triapine, gemcitabine",0.102372908709559,0,FALSE
+"A549","Pearson.est","serotonin receptor agonist",-0.51201,-1.34,0.17,916,0.645,"zolmitriptan, SR.57227A, aripiprazole, ipsapirone",0.769551078621726,0.190440285364732,FALSE
+"A549","Pearson.est","serotonin receptor antagonist",0.39403,1.01,0.426,276,0.958,"lerisetron, sertindole, lurasidone, pirenperone, tropisetron",0.370590400897281,0.0186344909214556,FALSE
+"A549","Pearson.est","sodium channel blocker",0.43254,1.12,0.318,302,1,"cibenzoline, lappaconite, oxcarbazepine, quinidine, triamterene, benzethonium",0.497572880015567,0,FALSE
+"A549","Pearson.est","src inhibitor",0.24809,0.646,0.871,1091,1,"PP.1, bosutinib, ZM.306416, saracatinib, PP.2, TG.100572, dasatinib, masitinib, KX2.391",0.0599818449923368,0,FALSE
+"A549","Pearson.est","sterol demethylase inhibitor",0.37216,0.989,0.451,221,0.886,"chlormidazole, terconazole",0.345823458122039,0.0525662781129492,FALSE
+"A549","Pearson.est","TGF beta receptor inhibitor",0.35744,0.917,0.563,86,0.87,"LY2109761",0.249491605148654,0.0604807473813815,FALSE
+"A549","Pearson.est","thymidylate synthase inhibitor",-0.36725,-0.984,0.436,1297,0.653,"raltitrexed, carmofur",0.360513510731414,0.185086818724926,FALSE
+"A549","Pearson.est","topoisomerase inhibitor",-0.2879,-0.762,0.753,1353,0.95,"amsacrine, idarubicin, voreloxin, TAS.103, valrubicin",0.123205023799299,0.0222763947111523,FALSE
+"A549","Pearson.est","tubulin polymerization inhibitor",0.18483,0.477,0.993,396,0.985,"indibulin, vinorelbine, vincristine, paclitaxel, vindesine, nocodazole, ABT.751, fenbendazole",0.00305075150461883,0.00656376950238827,FALSE
+"A549","Pearson.est","tyrosine kinase inhibitor",0.22787,0.583,0.934,336,0.975,"bafetinib, rheochrysidin, tivantinib, PP.121, sorafenib, tyrphostin.A9, apatinib",0.0296531237699066,0.0109953843014632,FALSE
+"A549","Pearson.est","VEGFR inhibitor",0.23853,0.619,0.902,149,0.988,"cediranib, lenvatinib, pazopanib, SAR131675, orantinib",0.0447934624580583,0.00524305541237188,FALSE
+"A549","Pearson.est","vitamin D receptor agonist",-0.40168,-1.05,0.376,986,0.623,"calcitriol, alfacalcidol, ercalcitriol, tacalcitol",0.424812155072339,0.20551195334083,FALSE
+"H1703","Pearson.est","EGFR inhibitor",0.43321,1.11,0.317,376,0.849,"tyrphostin.AG.1478, WZ8040, BIBX.1382, OSI.420, tyrphostin.AG.494, CGP.52411, BIBU.1361, icotinib, gefitinib, erlotinib, dacomitinib, AZD8931, PD.153035, canertinib, pelitinib, CP.724714, osimertinib, BMS.690514, tucatinib",0.498940737782249,0.0710923097560473,FALSE
+"H1703","Pearson.est","Abl kinase inhibitor",0.29464,0.754,0.768,11,0.907,"imatinib",0.114638779968488,0.0423927129399047,FALSE
+"H1703","Pearson.est","acetylcholine receptor agonist",0.36287,0.935,0.512,423,1,"nefiracetam, nicotine, oxiracetam",0.290730039024169,0,FALSE
+"H1703","Pearson.est","acetylcholine receptor antagonist",-0.27996,-0.738,0.747,1025,0.922,"methscopolamine, hyoscyamine, iododexetimide",0.126679398184601,0.0352690789463706,FALSE
+"H1703","Pearson.est","adenosine receptor antagonist",0.62421,1.58,0.0529,222,0.732,"MRS.1220, CGS.15943, SCH.58261, PSB.1115",1.27654432796481,0.135488918941608,FALSE
+"H1703","Pearson.est","adrenergic receptor agonist",0.3297,0.858,0.63,295,1,"oxymetazoline, clenbuterol, lidamidine, isoxsuprine",0.200659450546418,0,FALSE
+"H1703","Pearson.est","adrenergic receptor antagonist",-0.27192,-0.726,0.771,1178,0.903,"vincamine, prazosin, carvedilol, practolol, naftidrofuryl, dihydroergocristine",0.112945621949043,0.0443122496864942,FALSE
+"H1703","Pearson.est","AKT inhibitor",0.61667,1.54,0.0729,210,0.723,"uprosertib, CCT128930, AZD5363, palomid.529, triciribine, GDC.0068",1.13727247168203,0.140861702705469,FALSE
+"H1703","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.26542,0.689,0.854,357,0.918,"GW.788388, SB.505124, alectinib, NVP.TAE684",0.068542129310995,0.0371573187987575,FALSE
+"H1703","Pearson.est","androgen receptor antagonist",-0.31247,-0.838,0.646,1396,0.874,"flutamide",0.189767482004916,0.058488567365597,FALSE
+"H1703","Pearson.est","antioxidant",0.50091,1.27,0.202,458,0.674,"benfotiamine, mesna, chlorogenic.acid, taurine",0.694648630553376,0.17134010346468,FALSE
+"H1703","Pearson.est","AP inhibitor",-0.35381,-0.941,0.511,1417,0.904,"idronoxil",0.291579099865287,0.0438315695246367,FALSE
+"H1703","Pearson.est","ATPase inhibitor",-0.51611,-1.4,0.124,1428,0.544,"k.strophanthidin, oligomycin.a",0.906578314837765,0.26440110030182,FALSE
+"H1703","Pearson.est","Aurora kinase inhibitor",0.32019,0.817,0.689,413,1,"MLN.8054, barasertib, GSK1070916, ENMD.2076, KW.2449, PF.03814735, MK.8745, tozasertib",0.161780778092374,0,FALSE
+"H1703","Pearson.est","bacterial 50S ribosomal subunit inhibitor",-0.35201,-0.942,0.502,1367,0.962,"azithromycin, josamycin",0.299296282854981,0.0168249279621871,FALSE
+"H1703","Pearson.est","bacterial DNA gyrase inhibitor",-0.32693,-0.885,0.571,1269,0.87,"norfloxacin, lomefloxacin, sparfloxacin",0.243363891754152,0.0604807473813815,FALSE
+"H1703","Pearson.est","BCL inhibitor",0.36572,0.932,0.529,446,0.946,"venetoclax, oridonin, obatoclax, HA14.1, navitoclax",0.276544327964814,0.0241088635982073,FALSE
+"H1703","Pearson.est","Bcr.Abl kinase inhibitor",0.36819,0.932,0.528,11,0.946,"imatinib",0.277366077466188,0.0241088635982073,FALSE
+"H1703","Pearson.est","benzodiazepine receptor agonist",0.3132,0.814,0.688,359,1,"nefiracetam, lorazepam, CGS.20625, zaleplon, eprinomectin, ivermectin",0.162411561764489,0,FALSE
+"H1703","Pearson.est","bromodomain inhibitor",-0.4287,-1.08,0.368,1413,0.84,"PFI.1",0.434152181326482,0.0757207139381184,FALSE
+"H1703","Pearson.est","calcium channel blocker",0.28288,0.727,0.8,311,0.907,"cinnarazine, efonidipine.monoethanolate, pranidipine, SR.33805",0.0969100130080564,0.0423927129399047,FALSE
+"H1703","Pearson.est","CC chemokine receptor antagonist",-0.30035,-0.799,0.691,1255,0.862,"MK.0812, UNBS.5162",0.160521952625802,0.0644927341752872,FALSE
+"H1703","Pearson.est","CDK inhibitor",0.42243,1.06,0.399,299,0.931,"indirubin, AZD5438, TG.02, alvocidib, JNJ.7706621, kenpaullone, palbociclib, P276.00, PHA.793887",0.399027104313252,0.0310503190186574,FALSE
+"H1703","Pearson.est","CHK inhibitor",0.21284,0.534,0.965,141,1,"SCH.900776",0.0154726866562074,0,FALSE
+"H1703","Pearson.est","cyclooxygenase inhibitor",0.29621,0.752,0.756,352,0.891,"tryptanthrin, FR.122047, amfenac, aspirin, curcumin, phenylbutazone",0.121478204498793,0.0501222959631252,FALSE
+"H1703","Pearson.est","cytochrome P450 inhibitor",0.47405,1.21,0.252,64,0.77,"PF.4981517, itraconazole",0.598599459218456,0.113509274827518,FALSE
+"H1703","Pearson.est","DNA alkylating agent",-0.24955,-0.668,0.855,1362,0.912,"mitomycin.c, dianhydrogalactitol",0.0680338852718274,0.0400051616715838,FALSE
+"H1703","Pearson.est","DNA inhibitor",0.31127,0.782,0.705,54,0.998,"busulfan, nithiamide",0.151810883008601,0.000869458712628891,FALSE
+"H1703","Pearson.est","DNA methyltransferase inhibitor",0.53115,1.38,0.128,396,1,"azacitidine, fdcyd, decitabine",0.892790030352132,0,FALSE
+"H1703","Pearson.est","DNA polymerase inhibitor",0.4446,1.14,0.289,626,0.907,"famciclovir, foscarnet, cidofovir, idoxuridine, menadione, adefovir.dipivoxil",0.539102157243452,0.0423927129399047,FALSE
+"H1703","Pearson.est","DNA synthesis inhibitor",-0.3046,-0.832,0.634,1114,0.845,"artemisinin, enocitabine, nelarabine, azodicarbonamide, mitomycin.c, artesunate",0.197910742118267,0.0731432910503077,FALSE
+"H1703","Pearson.est","dopamine receptor antagonist",0.50365,1.29,0.176,314,0.721,"acetophenazine, mesoridazine, domperidone, ziprasidone, UH.232...., oxiperomide, remoxipride, clebopride",0.75448733218585,0.142064735280571,FALSE
+"H1703","Pearson.est","estrogen receptor agonist",-0.2647,-0.712,0.795,1104,0.888,"estradiol.cypionate, levonorgestrel",0.0996328713435297,0.051587034221399,FALSE
+"H1703","Pearson.est","estrogen receptor antagonist",-0.70779,-1.93,0.00959,1100,0.302,"raloxifene, fulvestrant, clomifene, toremifene",2.01818139282934,0.519993057042849,FALSE
+"H1703","Pearson.est","FGFR inhibitor",-0.34041,-0.901,0.549,1238,0.939,"dovitinib, regorafenib, erdafitinib",0.260427655549908,0.0273344077338891,FALSE
+"H1703","Pearson.est","FLT3 inhibitor",0.35513,0.899,0.549,413,0.96,"sunitinib, TG.02, tandutinib, pacritinib, ENMD.2076, lestaurtinib, GTP.14564, KW.2449, tozasertib",0.260427655549908,0.0177287669604316,FALSE
+"H1703","Pearson.est","glucocorticoid receptor agonist",-0.40874,-1.08,0.367,934,0.84,"rimexolone, prednisolone.acetate, ciclesonide, halcinonide, halobetasol.propionate, beclomethasone.dipropionate, triamcinolone, methylprednisolone, fluticasone.propionate, prednisolone.hemisuccinate, triamcinolone.acetonide, flumethasone.pivalate, betamethasone, fluorometholone, clobetasol.propionate, deflazacort",0.435333935747911,0.0757207139381184,FALSE
+"H1703","Pearson.est","glutamate receptor antagonist",0.39429,0.986,0.473,105,0.994,"diazooxonorleucine, SIB.1757, latrepirdine",0.325138859262188,0.00261361560268669,FALSE
+"H1703","Pearson.est","glycogen synthase kinase inhibitor",0.41632,1.04,0.386,524,0.899,"indirubin, CHIR.99021, GSK.3.inhibitor.IX, kenpaullone, LY2090314, tideglusib, CHIR.98014",0.413412695328245,0.0462403082667712,FALSE
+"H1703","Pearson.est","growth factor receptor inhibitor",0.2569,0.661,0.869,491,0.932,"GSK1904529A, lestaurtinib, GSK1838705A",0.0609802235513335,0.0305840876460186,FALSE
+"H1703","Pearson.est","HCV inhibitor",0.51867,1.34,0.158,116,0.769,"daclatasvir, PSI.7976",0.801342913045577,0.114073660198569,FALSE
+"H1703","Pearson.est","HDAC inhibitor",0.44742,1.13,0.315,404,0.887,"tacedinaline, R306465, vorinostat, romidepsin, pyroxamide, JNJ.26481585, panobinostat, resminostat, belinostat, ACY.1215, RG2833, RGFP966",0.501689446210399,0.0520763801682736,FALSE
+"H1703","Pearson.est","histamine receptor antagonist",0.38336,0.985,0.467,110,0.958,"levocetirizine, ranitidine, terfenadine",0.330683119433888,0.0186344909214556,FALSE
+"H1703","Pearson.est","HMGCR inhibitor",-0.6792,-1.79,0.0268,1126,0.23,"fluvastatin, atorvastatin, mevastatin, pitavastatin",1.57186520597121,0.638272163982407,TRUE
+"H1703","Pearson.est","HSP inhibitor",0.56801,1.47,0.103,514,0.846,"guanidine, KW.2478, PU.H71, BIIB021, SNX.5422, NVP.AUY922, XL888, tanespimycin, VER.49009",0.987162775294828,0.0726296369609765,FALSE
+"H1703","Pearson.est","JAK inhibitor",0.37795,0.95,0.513,329,1,"TG.02, atiprimod, pacritinib, filgotinib, CEP.33779, lestaurtinib",0.289882634888184,0,FALSE
+"H1703","Pearson.est","KIT inhibitor",0.4965,1.27,0.193,219,0.674,"imatinib, sunitinib, tandutinib, KI.8751, OSI.930",0.714442690992226,0.17134010346468,FALSE
+"H1703","Pearson.est","MDM inhibitor",0.5189,1.33,0.153,170,0.732,"nutlin.3, CGM097",0.815308569182401,0.135488918941608,FALSE
+"H1703","Pearson.est","MEK inhibitor",0.72377,1.87,0.012,145,0.427,"trametinib, AS.703026, PD.0325901, cobimetinib, MEK162, Ro.4987655, TAK.733, refametinib, AZD8330, selumetinib, PD.198306, PD.184352",1.92081875395238,0.369572124974976,FALSE
+"H1703","Pearson.est","MET inhibitor",-0.36893,-0.973,0.458,532,1,"PF.04217903, INC.280, AMG458, NVP.BVU972, LY2801653, PHA.665752",0.339134521996131,0,FALSE
+"H1703","Pearson.est","microtubule inhibitor",-0.36666,-0.965,0.471,1204,0.976,"secnidazole, cabazitaxel, D.64131",0.326979092871104,0.0105501823333082,FALSE
+"H1703","Pearson.est","mTOR inhibitor",0.18812,0.48,0.985,438,0.984,"PP242, palomid.529, GSK2126458, LY303511, XL388, WAY.600, torin.2, OSI.027, PF.05212384",0.00656376950238827,0.00700490156865849,FALSE
+"H1703","Pearson.est","NFkB pathway inhibitor",0.25545,0.656,0.874,467,0.919,"betulinic.acid, bortezomib, curcumin, bindarit, IKK.2.inhibitor.V",0.058488567365597,0.0366844886138887,FALSE
+"H1703","Pearson.est","opioid receptor agonist",0.68912,1.76,0.0168,392,0.482,"salvinorin.a, BW.180C, cebranopadol",1.77469071827414,0.31695296176115,FALSE
+"H1703","Pearson.est","p38 MAPK inhibitor",0.29923,0.756,0.726,234,0.925,"CMPD.1, skepinone.l",0.139063379299906,0.0338582672609674,FALSE
+"H1703","Pearson.est","PARP inhibitor",0.32398,0.807,0.692,493,1,"PJ.34, talazoparib, endo.IWR.1, AG.14361",0.159893905543242,0,FALSE
+"H1703","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.30912,0.78,0.725,520,0.977,"imatinib, sunitinib, tandutinib, KI.8751, SU014813, linifanib, orantinib, motesanib, axitinib, crenolanib, CP.673451",0.139661993429006,0.0101054362812269,FALSE
+"H1703","Pearson.est","phosphatase inhibitor",-0.32589,-0.885,0.574,1107,0.87,"CID.5458317, AS.1949490, bis.maltolato.oxovanadium.IV., GSK2830371",0.241088107602027,0.0604807473813815,FALSE
+"H1703","Pearson.est","phosphodiesterase inhibitor",0.32019,0.792,0.685,321,1,"cilostamide, anagrelide, zardaverine",0.164309428507574,0,FALSE
+"H1703","Pearson.est","PI3K inhibitor",0.31593,0.799,0.705,216,1,"CH5132799, CUDC.907, alpelisib, TG.100713, GSK2126458, TG100.115, LY303511",0.151810883008601,0,FALSE
+"H1703","Pearson.est","PLK inhibitor",-0.70766,-1.86,0.0221,1247,0.23,"NMS.1286937, volasertib, BI.2536, GSK461364",1.65560772631489,0.638272163982407,TRUE
+"H1703","Pearson.est","potassium channel blocker",0.52165,1.35,0.145,254,0.908,"oleoylethanolamide, meglitinide",0.838631997765025,0.0419141514789149,FALSE
+"H1703","Pearson.est","PPAR receptor agonist",0.52062,1.34,0.16,100,0.769,"oleoylethanolamide, S26948",0.795880017344075,0.114073660198569,FALSE
+"H1703","Pearson.est","progesterone receptor agonist",-0.43244,-1.17,0.277,990,0.873,"melengestrol.acetate, norethindrone, norgestrel, levonorgestrel, nomegestrol.acetate",0.557520230935551,0.0589857562944303,FALSE
+"H1703","Pearson.est","proteasome inhibitor",0.35968,0.922,0.529,547,0.938,"ixazomib.citrate, bortezomib, ixazomib, MG.132, carfilzomib, oprozomib",0.276544327964814,0.0277971616209356,FALSE
+"H1703","Pearson.est","protein synthesis inhibitor",-0.31218,-0.838,0.635,1264,0.874,"harringtonine, puromycin, clofoctol, mercaptopurine, anguidine",0.197226274708024,0.058488567365597,FALSE
+"H1703","Pearson.est","protein tyrosine kinase inhibitor",-0.44191,-1.2,0.225,1309,0.902,"tyrphostin.A9, rheochrysidin, mubritinib",0.647817481888638,0.0447934624580583,FALSE
+"H1703","Pearson.est","RAF inhibitor",0.3051,0.772,0.753,178,0.967,"AZ.628, dabrafenib, CEP.32496",0.123205023799299,0.0145735259169983,FALSE
+"H1703","Pearson.est","RET tyrosine kinase inhibitor",0.41025,1.05,0.381,275,0.915,"sunitinib, apatinib",0.419075024324381,0.0385789059335517,FALSE
+"H1703","Pearson.est","retinoid receptor agonist",-0.42994,-1.16,0.271,1205,0.807,"adapalene, LE.135, AM.580, bexarotene, fenretinide",0.567030709125594,0.0931264652779296,FALSE
+"H1703","Pearson.est","ribonucleotide reductase inhibitor",-0.61188,-1.67,0.0536,1237,0.215,"gemcitabine, cladribine, fludarabine, clofarabine, pentostatin",1.27083521030723,0.667561540084395,FALSE
+"H1703","Pearson.est","serotonin receptor agonist",0.64049,1.64,0.0339,32,0.7,"aripiprazole, ipsapirone",1.46980030179692,0.154901959985743,FALSE
+"H1703","Pearson.est","serotonin receptor antagonist",0.51339,1.31,0.187,330,0.725,"aripiprazole, ziprasidone, SB.228357, RS.16566, tropisetron",0.728158393463501,0.139661993429006,FALSE
+"H1703","Pearson.est","sodium channel blocker",0.29577,0.769,0.74,383,0.949,"A.803467, ajmaline, lappaconite, benzethonium, triamterene, brivaracetam",0.130768280269024,0.0227337875727074,FALSE
+"H1703","Pearson.est","src inhibitor",-0.18581,-0.505,0.98,1188,0.978,"ZM.306416, TG.100572",0.00877392430750515,0.00966114521239857,FALSE
+"H1703","Pearson.est","sterol demethylase inhibitor",-0.60734,-1.67,0.0508,950,0.215,"sulconazole, ketoconazole, chlormidazole, posaconazole, lanoconazole",1.29413628771608,0.667561540084395,FALSE
+"H1703","Pearson.est","TGF beta receptor inhibitor",0.53509,1.35,0.136,401,0.908,"LY2109761, D.4476, repsox, SB.431542",0.866461091629782,0.0419141514789149,FALSE
+"H1703","Pearson.est","thymidylate synthase inhibitor",0.30049,0.765,0.749,419,0.933,"carmofur, capecitabine, raltitrexed",0.125518182300534,0.0301183562535,FALSE
+"H1703","Pearson.est","topoisomerase inhibitor",-0.64092,-1.75,0.0259,1139,0.219,"voreloxin, exatecan.mesylate, daunorubicin, valrubicin, teniposide, nemorubicin, amonafide, etoposide, idarubicin, TAS.103, dexrazoxane, licochalcone.a, doxorubicin, amsacrine, etoposide.phosphate, epirubicin, mitoxantrone",1.58670023591875,0.659555885159882,TRUE
+"H1703","Pearson.est","tubulin polymerization inhibitor",-0.21559,-0.583,0.938,873,0.966,"nocodazole, BNC105, parbendazole, podophyllotoxin, flubendazole, KX2.391, mebendazole, vincristine, oxibendazole, ABT.751, epothilone.b, dolastatin.10, fenbendazole, CYT.997",0.0277971616209356,0.0150228735845067,FALSE
+"H1703","Pearson.est","tyrosine kinase inhibitor",0.19389,0.501,0.984,317,0.996,"sunitinib, UNC2250, tivantinib, apatinib, NVP.TAE226, CP.724714",0.00700490156865849,0.00174066157630127,FALSE
+"H1703","Pearson.est","VEGFR inhibitor",0.27579,0.701,0.803,358,0.923,"MGCD.265, sunitinib, semaxanib, KI.8751, PD.173074, OSI.930, SU014813, ENMD.2076, linifanib, orantinib, BMS.690514",0.095284454721319,0.0347982989740879,FALSE
+"H1703","Pearson.est","vitamin D receptor agonist",0.4427,1.11,0.319,107,0.849,"calcitriol, ercalcitriol",0.496209316942819,0.0710923097560473,FALSE
+"HCC15","Pearson.est","EGFR inhibitor",0.21964,0.54,0.963,281,0.987,"CUDC.101, BIBX.1382, tucatinib, FERb.033, tyrphostin.AG.494, gefitinib, canertinib, BMS.690514",0.0163737128754655,0.00568284733036327,FALSE
+"HCC15","Pearson.est","Abl kinase inhibitor",-0.49591,-1.26,0.21,1240,0.878,"bafetinib, metatinib, dasatinib, ponatinib",0.677780705266081,0.0565054840938974,FALSE
+"HCC15","Pearson.est","acetylcholine receptor agonist",0.49011,1.22,0.245,690,0.746,"nicotine, xanomeline, oxiracetam, nefiracetam, tremorine",0.610833915635468,0.127261172527331,FALSE
+"HCC15","Pearson.est","acetylcholine receptor antagonist",-0.64387,-1.67,0.0438,1326,1,"hyoscyamine, diphemanil",1.3585258894959,0,FALSE
+"HCC15","Pearson.est","adenosine receptor antagonist",-0.44275,-1.17,0.243,1434,0.869,"theophylline",0.614393726401688,0.0609802235513335,FALSE
+"HCC15","Pearson.est","adrenergic receptor agonist",-0.27365,-0.72,0.76,1415,0.86,"A61603, norepinephrine",0.119186407719209,0.0655015487564323,FALSE
+"HCC15","Pearson.est","adrenergic receptor antagonist",-0.35113,-0.937,0.496,1280,0.857,"idazoxan, practolol, naftidrofuryl, carvedilol, dihydroergocristine, metoprolol",0.304518323509803,0.0670191780768018,FALSE
+"HCC15","Pearson.est","AKT inhibitor",0.54041,1.35,0.144,34,0.814,"uprosertib, GDC.0068, AZD5363",0.84163750790475,0.0893755951107988,FALSE
+"HCC15","Pearson.est","ALK tyrosine kinase receptor inhibitor",0.39133,0.95,0.5,302,0.743,"SB.505124, alectinib, GW.788388, DMH1",0.301029995663981,0.129011186239425,FALSE
+"HCC15","Pearson.est","androgen receptor antagonist",-0.37911,-1.02,0.393,1231,0.939,"flutamide, enzalutamide, cyproterone.acetate",0.405607449624573,0.0273344077338891,FALSE
+"HCC15","Pearson.est","antioxidant",0.30934,0.751,0.75,139,0.861,"benfotiamine",0.1249387366083,0.0649968485463452,FALSE
+"HCC15","Pearson.est","AP inhibitor",0.22684,0.552,0.954,465,1,"embelin, birinapant",0.0204516252959049,0,FALSE
+"HCC15","Pearson.est","ATPase inhibitor",0.47086,1.19,0.249,345,0.768,"k.strophanthidin, thonzonium, digoxin, omeprazole, NMS.873",0.603800652904264,0.114638779968488,FALSE
+"HCC15","Pearson.est","Aurora kinase inhibitor",0.3074,0.76,0.747,307,0.871,"barasertib, aurora.a.inhibitor.i, ENMD.2076, alisertib, AMG900, tozasertib, CCT137690, MK.8745",0.126679398184601,0.0599818449923368,FALSE
+"HCC15","Pearson.est","bacterial 50S ribosomal subunit inhibitor",0.38528,0.968,0.481,330,0.764,"azalomycin.b, tedizolid, tilmicosin",0.317854923626168,0.11690664142431,FALSE
+"HCC15","Pearson.est","bacterial DNA gyrase inhibitor",0.53163,1.34,0.139,505,0.752,"norfloxacin, sarafloxacin, finafloxacin, lomefloxacin, trovafloxacin, novobiocin",0.856985199745905,0.123782159408358,FALSE
+"HCC15","Pearson.est","BCL inhibitor",0.42198,1.05,0.398,397,0.692,"oridonin, venetoclax, gossypol, HA14.1",0.400116927926312,0.159893905543242,FALSE
+"HCC15","Pearson.est","Bcr.Abl kinase inhibitor",-0.54543,-1.4,0.128,1240,0.987,"bafetinib, metatinib, dasatinib, ponatinib",0.892790030352132,0.00568284733036327,FALSE
+"HCC15","Pearson.est","benzodiazepine receptor agonist",-0.28558,-0.745,0.741,939,0.873,"eprinomectin, ivermectin, ZK.93423, piperazine, bentazepam, temazepam, gamma.aminobutyric.acid, indiplon",0.130181792020672,0.0589857562944303,FALSE
+"HCC15","Pearson.est","bromodomain inhibitor",0.46018,1.13,0.303,56,0.691,"JQ1...., I.BET151",0.518557371497695,0.160521952625802,FALSE
+"HCC15","Pearson.est","calcium channel blocker",0.47579,1.17,0.259,270,0.681,"SR.33805, tetrandrine, mibefradil, SKF.96365, cinnarazine",0.586700235918748,0.166852888087215,FALSE
+"HCC15","Pearson.est","CC chemokine receptor antagonist",-0.30124,-0.788,0.71,1416,0.881,"UNBS.5162",0.148741651280925,0.0550240915879521,FALSE
+"HCC15","Pearson.est","CDK inhibitor",0.3808,0.941,0.514,114,0.735,"AZD5438, JNJ.7706621, TG.02, R547",0.289036881004724,0.133712660915805,FALSE
+"HCC15","Pearson.est","CHK inhibitor",-0.43832,-1.14,0.285,1147,0.88,"AZD7762, CHIR.124, LY2606368",0.54515513999149,0.0555173278498314,FALSE
+"HCC15","Pearson.est","cyclooxygenase inhibitor",-0.29296,-0.764,0.746,1097,0.894,"metoxibutropate, acetylsalicylsalicylic.acid, FK.3311, suxibuzone, ramifenazone, AM.404, indoprofen",0.127261172527331,0.0486624812040823,FALSE
+"HCC15","Pearson.est","cytochrome P450 inhibitor",0.47248,1.18,0.251,126,0.743,"itraconazole",0.600326278518962,0.129011186239425,FALSE
+"HCC15","Pearson.est","DNA alkylating agent",-0.3599,-0.95,0.494,1339,0.869,"streptozotocin, mitomycin.c, dianhydrogalactitol",0.306273051076353,0.0609802235513335,FALSE
+"HCC15","Pearson.est","DNA inhibitor",-0.27467,-0.72,0.786,1218,0.86,"bendamustine, carboplatin, mechlorethamine, teroxirone, tirapazamine",0.104577453960592,0.0655015487564323,FALSE
+"HCC15","Pearson.est","DNA methyltransferase inhibitor",0.53013,1.31,0.165,401,0.762,"azacitidine, decitabine, SGI.1027, fdcyd",0.782516055786094,0.1180450286604,FALSE
+"HCC15","Pearson.est","DNA polymerase inhibitor",0.6005,1.49,0.077,448,0.577,"trifluridine, cidofovir, adefovir.dipivoxil, cephalomannine, menadione",1.11350927482752,0.238824186844269,FALSE
+"HCC15","Pearson.est","DNA synthesis inhibitor",-0.42695,-1.08,0.329,1023,0.907,"enocitabine, floxuridine, cisplatin, artesunate, altretamine, nelarabine, estramustine.phosphate, mitomycin.c",0.482804102050026,0.0423927129399047,FALSE
+"HCC15","Pearson.est","dopamine receptor antagonist",0.44334,1.14,0.308,166,0.707,"mesoridazine, raclopride, ziprasidone, clebopride, domperidone",0.511449283499556,0.150580586203101,FALSE
+"HCC15","Pearson.est","estrogen receptor agonist",-0.49485,-1.26,0.21,1301,0.878,"levonorgestrel, estradiol.cypionate, equol",0.677780705266081,0.0565054840938974,FALSE
+"HCC15","Pearson.est","estrogen receptor antagonist",-0.48024,-1.23,0.234,1116,0.791,"danazol, fulvestrant, toremifene",0.630784142589857,0.101823516502323,FALSE
+"HCC15","Pearson.est","FGFR inhibitor",0.4842,1.17,0.283,133,0.681,"lucitanib, nintedanib",0.54821356447571,0.166852888087215,FALSE
+"HCC15","Pearson.est","FLT3 inhibitor",0.34022,0.828,0.686,422,0.858,"sorafenib, TG.02, ENMD.2076, tozasertib, sunitinib, tandutinib",0.163675884293248,0.0665127121512946,FALSE
+"HCC15","Pearson.est","glucocorticoid receptor agonist",-0.38592,-1.01,0.434,1124,0.863,"triamcinolone, flumethasone.pivalate, fluticasone.propionate, flumethasone, methylprednisolone, beclomethasone.dipropionate, rimexolone, betamethasone, deflazacort, fluorometholone, clobetasol.propionate",0.362510270487489,0.0639892042847904,FALSE
+"HCC15","Pearson.est","glutamate receptor antagonist",-0.39969,-1.03,0.404,1095,0.974,"kynurenic.acid, CGP.37849, tiletamine, CPP, MTPG, LY456236",0.393618634889395,0.0114410431213845,FALSE
+"HCC15","Pearson.est","glycogen synthase kinase inhibitor",0.22886,0.558,0.959,592,1,"CHIR.99021, tideglusib, GSK.3.inhibitor.IX, indirubin, kenpaullone",0.0181813928293364,0,FALSE
+"HCC15","Pearson.est","growth factor receptor inhibitor",-0.35286,-0.902,0.559,1253,0.894,"PHA.848125, GW.441756",0.252588192113577,0.0486624812040823,FALSE
+"HCC15","Pearson.est","HCV inhibitor",0.44357,1.1,0.355,392,0.684,"narlaprevir, embelin, daclatasvir",0.449771646944906,0.164943898279884,FALSE
+"HCC15","Pearson.est","HDAC inhibitor",0.37552,0.936,0.536,369,0.7,"R306465, RGFP966, pyroxamide, ACY.1215, vorinostat, belinostat, romidepsin, PCI.24781, trichostatin.a",0.27083521030723,0.154901959985743,FALSE
+"HCC15","Pearson.est","histamine receptor antagonist",-0.31356,-0.79,0.709,1118,0.908,"lafutidine, tiotidine, astemizole, terfenadine, BF2.649, zolantidine",0.149353764816933,0.0419141514789149,FALSE
+"HCC15","Pearson.est","HMGCR inhibitor",-0.23041,-0.623,0.915,1081,0.904,"fluvastatin, mevastatin, pitavastatin",0.0385789059335517,0.0438315695246367,FALSE
+"HCC15","Pearson.est","HSP inhibitor",0.50939,1.24,0.211,346,0.75,"NMS.E973, guanidine, KW.2478, BIIB021, PU.H71, NVP.AUY922, SNX.2112",0.675717544702307,0.1249387366083,FALSE
+"HCC15","Pearson.est","JAK inhibitor",0.31681,0.774,0.746,325,0.874,"atiprimod, TG.02, tozasertib, filgotinib, AZD1480",0.127261172527331,0.058488567365597,FALSE
+"HCC15","Pearson.est","KIT inhibitor",0.43297,1.07,0.381,595,0.713,"sorafenib, OSI.930, telatinib, cediranib, sunitinib, KI.8751, tandutinib, lenvatinib, masitinib, regorafenib, imatinib",0.419075024324381,0.146910470148134,FALSE
+"HCC15","Pearson.est","MDM inhibitor",-0.56283,-1.5,0.0802,1182,1,"RITA, AMG.232, idasanutlin",1.09582563171584,0,FALSE
+"HCC15","Pearson.est","MEK inhibitor",0.42372,1.04,0.401,387,0.683,"MEK162, AZD8330, TAK.733, PD.0325901, cobimetinib, PD.318088, Ro.4987655, trametinib, AS.703026",0.396855627379818,0.165579296318467,FALSE
+"HCC15","Pearson.est","MET inhibitor",-0.37895,-0.979,0.463,1017,0.846,"PF.04217903, LY2801653, NVP.BVU972, PHA.665752",0.334419008982047,0.0726296369609765,FALSE
+"HCC15","Pearson.est","microtubule inhibitor",0.38626,0.963,0.489,313,0.747,"vinblastine, vinflunine, podophyllotoxin",0.31069114087638,0.126679398184601,FALSE
+"HCC15","Pearson.est","mTOR inhibitor",-0.34263,-0.896,0.558,1174,0.871,"WYE.125132, PI.103, temsirolimus, everolimus, NVP.BEZ235, MLN0128, GDC.0980, SB.2343, deforolimus",0.253365801062421,0.0599818449923368,FALSE
+"HCC15","Pearson.est","NFkB pathway inhibitor",0.66576,1.64,0.0389,191,0.379,"betulinic.acid, curcumin, bortezomib, IKK.2.inhibitor.V, parthenolide....",1.41005039867429,0.421360790031928,FALSE
+"HCC15","Pearson.est","opioid receptor agonist",0.7326,1.83,0.0067,271,0.185,"salvinorin.a, cebranopadol, trimebutine",2.17392519729917,0.732828271596986,TRUE
+"HCC15","Pearson.est","p38 MAPK inhibitor",0.61871,1.53,0.0665,272,0.562,"CMPD.1, TAK.715, skepinone.l",1.1771783546969,0.250263684430939,FALSE
+"HCC15","Pearson.est","PARP inhibitor",-0.26042,-0.668,0.852,375,0.879,"PJ.34, niraparib, E7449, talazoparib, AG.14361, olaparib, AZD2461, endo.IWR.1",0.0695604052332999,0.0560111249262281,FALSE
+"HCC15","Pearson.est","PDGFR tyrosine kinase receptor inhibitor",0.3807,0.938,0.526,595,0.718,"sorafenib, telatinib, CP.673451, nintedanib, crenolanib, sunitinib, KI.8751, tandutinib, linifanib, lenvatinib, SU014813, masitinib, axitinib, regorafenib, imatinib",0.279014255846261,0.1438755557577,FALSE
+"HCC15","Pearson.est","phosphatase inhibitor",0.32822,0.822,0.641,460,0.843,"alexidine, CID.5458317, menadione, mycophenolic.acid",0.193141970481183,0.0741724253752577,FALSE
+"HCC15","Pearson.est","phosphodiesterase inhibitor",-0.38338,-0.998,0.449,1154,0.846,"GSK256066, YM.976, trequinsin",0.347753658996677,0.0726296369609765,FALSE
+"HCC15","Pearson.est","PI3K inhibitor",0.25348,0.628,0.876,109,0.988,"CH5132799, buparlisib, CUDC.907, pilaralisib",0.0574958938319193,0.00524305541237188,FALSE
+"HCC15","Pearson.est","PLK inhibitor",-0.52063,-1.35,0.175,1369,0.975,"BI.2536, GSK461364",0.756961951313706,0.0109953843014632,FALSE
+"HCC15","Pearson.est","potassium channel blocker",-0.25817,-0.67,0.841,1349,0.9,"ibutilide",0.0752040042020878,0.0457574905606751,FALSE
+"HCC15","Pearson.est","PPAR receptor agonist",-0.29981,-0.76,0.749,1099,0.873,"clofibrate, fenofibrate, ciprofibrate",0.125518182300534,0.0589857562944303,FALSE
+"HCC15","Pearson.est","progesterone receptor agonist",-0.33383,-0.867,0.608,1116,0.861,"danazol, norethindrone.acetate, dienogest, levonorgestrel, nomegestrol.acetate",0.216096420727265,0.0649968485463452,FALSE
+"HCC15","Pearson.est","proteasome inhibitor",0.7039,1.71,0.0186,342,0.306,"MG.132, bortezomib, ixazomib.citrate, oprozomib, ixazomib, carfilzomib",1.73048705578208,0.51427857351842,FALSE
+"HCC15","Pearson.est","protein synthesis inhibitor",-0.3392,-0.871,0.583,1328,0.887,"anguidine, clindamycin.phosphate, homoharringtonine, clofoctol, mercaptopurine",0.234331445240986,0.0520763801682736,FALSE
+"HCC15","Pearson.est","protein tyrosine kinase inhibitor",-0.30972,-0.812,0.695,446,0.901,"NVP.TAE226, tyrphostin.A9, mubritinib, PP.121, BMS.599626, CP.724714, rheochrysidin, AV.412",0.158015195409886,0.045275209020937,FALSE
+"HCC15","Pearson.est","RAF inhibitor",0.52199,1.29,0.182,160,0.746,"SB.590885, sorafenib, dabrafenib, RAF265",0.739928612014925,0.127261172527331,FALSE
+"HCC15","Pearson.est","RET tyrosine kinase inhibitor",0.50687,1.26,0.213,366,0.76,"sorafenib, apatinib, sunitinib",0.671620396561262,0.119186407719209,FALSE
+"HCC15","Pearson.est","retinoid receptor agonist",-0.48294,-1.27,0.209,1344,1,"AM.580, LE.135, bexarotene",0.679853713888946,0,FALSE
+"HCC15","Pearson.est","ribonucleotide reductase inhibitor",-0.59003,-1.54,0.0871,1266,1,"gemcitabine, pentostatin, cladribine, fludarabine, clofarabine",1.05998184499234,0,FALSE
+"HCC15","Pearson.est","serotonin receptor agonist",0.42785,1.06,0.382,297,0.703,"ipsapirone, zolmitriptan, SR.57227A, pardoprunox",0.417936637088291,0.153044674980176,FALSE
+"HCC15","Pearson.est","serotonin receptor antagonist",0.45498,1.12,0.331,108,0.677,"ziprasidone, lerisetron, tropisetron, pirenperone",0.480172006224281,0.169411331314856,FALSE
+"HCC15","Pearson.est","sodium channel blocker",0.17621,0.437,0.998,634,0.995,"benzocaine, brivaracetam, ajmaline, A.803467, mexiletine, triamterene, lappaconite, benzethonium",0.000869458712628891,0.00217691925427455,FALSE
+"HCC15","Pearson.est","src inhibitor",-0.41442,-1.09,0.333,1008,0.945,"saracatinib, PP.1, TG.100572, dasatinib",0.47755576649368,0.0245681914907371,FALSE
+"HCC15","Pearson.est","sterol demethylase inhibitor",-0.56842,-1.48,0.0914,1219,0.93,"ketoconazole, lanoconazole, terconazole",1.03905380426617,0.0315170514460649,FALSE
+"HCC15","Pearson.est","TGF beta receptor inhibitor",0.796,1.99,0.00323,111,0.0787,"SB.525334, LY2109761, repsox, D.4476",2.4907974776689,1.10402526764094,TRUE
+"HCC15","Pearson.est","thymidylate synthase inhibitor",-0.32481,-0.844,0.636,1432,0.872,"doxifluridine",0.196542884351586,0.0594835150674328,FALSE
+"HCC15","Pearson.est","topoisomerase inhibitor",-0.47308,-1.23,0.222,1177,0.791,"amonafide, exatecan.mesylate, epirubicin, etoposide, idarubicin, nemorubicin, TAS.103, amsacrine, mitoxantrone, licochalcone.a",0.653647025549361,0.101823516502323,FALSE
+"HCC15","Pearson.est","tubulin polymerization inhibitor",0.55843,1.39,0.129,323,0.785,"vinblastine, vinorelbine, albendazole, fosbretabulin, vindesine, verubulin, plinabulin, taltobulin, BNC105, vincristine, indibulin, flubendazole, podophyllotoxin, docetaxel",0.889410289700751,0.105130343254747,FALSE
+"HCC15","Pearson.est","tyrosine kinase inhibitor",0.32619,0.81,0.673,35,0.841,"sorafenib, tivantinib, UNC2250",0.171984935776023,0.0752040042020878,FALSE
+"HCC15","Pearson.est","VEGFR inhibitor",0.39319,0.992,0.442,523,0.744,"sorafenib, OSI.930, lucitanib, telatinib, nintedanib, cediranib, RAF265, ENMD.2076, tivozanib, BMS.690514, sunitinib, KI.8751, linifanib, lenvatinib, SU014813, semaxanib, MGCD.265",0.354577730650908,0.128427064454121,FALSE
+"HCC15","Pearson.est","vitamin D receptor agonist",-0.39773,-1.01,0.418,1052,0.863,"tacalcitol, maxacalcitol, paricalcitol, doxercalciferol",0.378823718224965,0.0639892042847904,FALSE
diff --git a/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_venn_diagram.pdf b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_venn_diagram.pdf
new file mode 100644
index 0000000..bba2ac5
Binary files /dev/null and b/Examples/ssDMEA_WV/Coldren_trascr_NSCLC/DMEA/DMEA_venn_diagram.pdf differ
diff --git a/LICENSE b/LICENSE
old mode 100755
new mode 100644
index e541da1..6b84c71
--- a/LICENSE
+++ b/LICENSE
@@ -1,23 +1,21 @@
-LICENSE
-Copyright Battelle Memorial Institute 2025
- 
-Redistribution and use in source and binary forms, with or without
-modification, are permitted provided that the following conditions are met:
- 
-1. Redistributions of source code must retain the above copyright notice, this
-list of conditions and the following disclaimer.
- 
-2. Redistributions in binary form must reproduce the above copyright notice,
-this list of conditions and the following disclaimer in the documentation
-and/or other materials provided with the distribution.
- 
-THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND
-ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED
-WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE
-DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE LIABLE
-FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
-DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
-SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER
-CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
-OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
-OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
\ No newline at end of file
+MIT License
+
+Copyright (c) 2023 Belinda B. Garana
+
+Permission is hereby granted, free of charge, to any person obtaining a copy
+of this software and associated documentation files (the "Software"), to deal
+in the Software without restriction, including without limitation the rights
+to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+copies of the Software, and to permit persons to whom the Software is
+furnished to do so, subject to the following conditions:
+
+The above copyright notice and this permission notice shall be included in all
+copies or substantial portions of the Software.
+
+THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
+AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+SOFTWARE.
diff --git a/R/.DS_Store b/R/.DS_Store
new file mode 100644
index 0000000..42c16ac
Binary files /dev/null and b/R/.DS_Store differ
diff --git a/R/DMAI.R b/R/DMAI.R
deleted file mode 100755
index 5ea0c4a..0000000
--- a/R/DMAI.R
+++ /dev/null
@@ -1,135 +0,0 @@
-DMAI <- function(drug.sensitivity, gmt = NULL, expression, weights,
-                 value = "AUC", sample.names = colnames(expression)[1],
-                 gene.names = colnames(weights)[1],
-                 weight.values = colnames(weights)[2],
-                 rank.metric = "Pearson.est", FDR = 0.25,
-                 num.permutations = 1000, stat.type = "Weighted",
-                 drug.info = NULL, drug = "Drug", set.type = "moa",
-                 min.per.set = 6, sep = "[|]",
-                 exclusions = c("-666", "NA", "na", "NaN", "NULL"),
-                 descriptions = NULL, min.per.corr = 3, scatter.plots = TRUE,
-                 scatter.plot.type = "pearson", FDR.scatter.plots = 0.05,
-                 xlab = "Weighted Voting Score", ylab = value,
-                 position.x = "min", position.y = "min", se = TRUE, ties = FALSE) {
-  # check classes of expression and weight data frames are as expected
-  testthat::expect_is(expression, "data.frame")
-  testthat::expect_is(weights, "data.frame")
-
-  # Weighted Voting (WV)
-  WV.result <- panSEA::WV(
-    expression = expression, weights = weights,
-    sample.names = sample.names, gene.names = gene.names,
-    weight.values = weight.values
-  )
-
-  used.weights <- weights[!(weights[,gene.names] %in% WV.result$unused.weights[,gene.names]),]
-  # Find out how many cores are available
-  if (requireNamespace("parallel") &
-      requireNamespace("snow") &
-      requireNamespace("doSNOW")) {
-    cores <- parallel::detectCores()
-    if (cores[1] > 1) {
-      cl <- snow::makeCluster(cores[1] - 1) # cluster using all but 1 core
-      doSNOW::registerDoSNOW(cl) # register cluster
-    }
-  }
-  
-  ### optional: weight permutations (for biomarker selection)
-  if (marker.select) {
-    WVMarkerArray <- matrix(data = NA, nrow = nperm,
-                            ncol = length(Drug.Sets.All))
-    num.Drug.Sets.all <- length(Drug.Sets.All)
-    `%dopar%` <- foreach::`%dopar%`
-    
-    WVMarkerArray <- foreach::foreach(L = seq_len(nrow(used.weights)),
-                                      .combine = "rbind") %dopar% {
-                                        temp.KSMarkerArray <- matrix(data = NA, nrow = 1,
-                                                                     ncol = num.Drug.Sets.all)
-                                        for (i in seq_len(length(Drug.Sets.All))) {
-                                          pos_gene_set <- which(temp.input[, Drug.Sets.All[i]] %in% c("X"))
-                                          
-                                          # calculate enrichment score for each drug set and rank list which excluded each gene
-                                          temp.KSMarkerArray[, i] <- GSEA.EnrichmentScore(marker.perms[,L],
-                                                                                          pos_gene_set,
-                                                                                          weighted.score.type = score.weight,
-                                                                                          correl.vector = rank_metric
-                                          )$ES
-                                        }
-                                        temp.KSMarkerArray
-                                      }
-    colnames(KSMarkerArray) <- Drug.Sets.All
-    KSMarkerArray <- as.data.frame(KSMarkerArray) 
-    
-    markerDiff <- KSMarkerArray - GSEA.Results$ES # check this will subtract first ES from first column values
-  }
-  
-  if (requireNamespace("parallel") &
-      requireNamespace("snow") &
-      requireNamespace("doSNOW")) {
-    if (cores[1] > 1) {
-      snow::stopCluster(cl) # stop cluster
-      rm(cl)
-    }
-  }
-  
-  # check classes of drug sensitivity data and WV output are as expected
-  testthat::expect_is(drug.sensitivity, "data.frame")
-  testthat::expect_is(WV.result$scores, "data.frame")
-
-  # merge drug sensitivity dataframe with WV
-  WV.result.drug.sensitivity <- merge(WV.result$scores, drug.sensitivity,
-    by = sample.names
-  )
-
-  # rank_corr
-  corr.results <- rank_corr(
-    data = WV.result.drug.sensitivity, variable = drug, value = value,
-    type = scatter.plot.type, min.per.corr = min.per.corr,
-    plots = scatter.plots, FDR = FDR.scatter.plots, xlab = xlab, ylab = ylab,
-    position.x = position.x, position.y = position.y, se = se
-  )
-
-  # check class of rank_corr output is as expected
-  testthat::expect_is(corr.results$result, "data.frame")
-
-  # if necessary, generate gmt object
-  if (is.null(gmt)) {
-    if (is.null(drug.info)) {
-      stop(paste(
-        "drug.info dataframe containing set membership information",
-        "must be provided as input if no gmt object is provided"
-      ))
-    } else {
-      corr.output <- merge(corr.results$result, drug.info, by = drug)
-      gmt <- as_gmt(
-        data = corr.output, element.names = drug, set.names = set.type,
-        min.per.set, sep, exclusions, descriptions
-      )
-    }
-  } else {
-    corr.output <- corr.results$result
-  }
-
-  # Drug Mechanism Enrichment Analysis (DMEA)
-  DMEA.results <- panSEA::drugSEA_ties(
-    data = corr.output, gmt = gmt, drug = drug, rank.metric = rank.metric, 
-    set.type = set.type, direction.adjust = NULL, FDR = FDR, 
-    num.permutations = num.permutations, stat.type = stat.type, 
-    min.per.set = min.per.set, sep = sep, exclusions = exclusions, 
-    descriptions = descriptions, convert.synonyms = FALSE, ties = ties
-  )
-
-  return(list(
-    WV.scores = WV.result$scores,
-    unused.weights = WV.result$unused.weights,
-    corr.result = corr.results$result,
-    corr.scatter.plots = corr.results$scatter.plots,
-    gmt = gmt,
-    result = DMEA.results$result,
-    result.w.ties = DMEA.results$result.w.ties,
-    mtn.plots = DMEA.results$mtn.plots,
-    volcano.plot = DMEA.results$volcano.plot,
-    removed.sets = DMEA.results$removed.sets,
-    unannotated.drugs = DMEA.results$unannotated.drugs
-  ))
-}
diff --git a/R/DMEA.R b/R/DMEA.R
deleted file mode 100755
index d68775e..0000000
--- a/R/DMEA.R
+++ /dev/null
@@ -1,85 +0,0 @@
-DMEA <- function(drug.sensitivity, gmt = NULL, expression, weights,
-                 value = "AUC", sample.names = colnames(expression)[1],
-                 gene.names = colnames(weights)[1],
-                 weight.values = colnames(weights)[2],
-                 rank.metric = "Pearson.est", FDR = 0.25,
-                 num.permutations = 1000, stat.type = "Weighted",
-                 drug.info = NULL, drug = "Drug", set.type = "moa",
-                 min.per.set = 6, sep = "[|]",
-                 exclusions = c("-666", "NA", "na", "NaN", "NULL"),
-                 descriptions = NULL, min.per.corr = 3, scatter.plots = TRUE,
-                 scatter.plot.type = "pearson", FDR.scatter.plots = 0.05,
-                 xlab = "Weighted Voting Score", ylab = value,
-                 position.x = "min", position.y = "min", se = TRUE, ties = FALSE) {
-  # check classes of expression and weight data frames are as expected
-  testthat::expect_is(expression, "data.frame")
-  testthat::expect_is(weights, "data.frame")
-
-  # Weighted Voting (WV)
-  WV.result <- panSEA::WV(
-    expression = expression, weights = weights,
-    sample.names = sample.names, gene.names = gene.names,
-    weight.values = weight.values
-  )
-
-  # check classes of drug sensitivity data and WV output are as expected
-  testthat::expect_is(drug.sensitivity, "data.frame")
-  testthat::expect_is(WV.result$scores, "data.frame")
-
-  # merge drug sensitivity dataframe with WV
-  WV.result.drug.sensitivity <- merge(WV.result$scores, drug.sensitivity,
-    by = sample.names
-  )
-
-  # rank_corr
-  corr.results <- rank_corr(
-    data = WV.result.drug.sensitivity, variable = drug, value = value,
-    type = scatter.plot.type, min.per.corr = min.per.corr,
-    plots = scatter.plots, FDR = FDR.scatter.plots, xlab = xlab, ylab = ylab,
-    position.x = position.x, position.y = position.y, se = se
-  )
-
-  # check class of rank_corr output is as expected
-  testthat::expect_is(corr.results$result, "data.frame")
-
-  # if necessary, generate gmt object
-  if (is.null(gmt)) {
-    if (is.null(drug.info)) {
-      stop(paste(
-        "drug.info dataframe containing set membership information",
-        "must be provided as input if no gmt object is provided"
-      ))
-    } else {
-      corr.output <- merge(corr.results$result, drug.info, by = drug)
-      gmt <- as_gmt(
-        data = corr.output, element.names = drug, set.names = set.type,
-        min.per.set, sep, exclusions, descriptions
-      )
-    }
-  } else {
-    corr.output <- corr.results$result
-  }
-
-  # Drug Mechanism Enrichment Analysis (DMEA)
-  DMEA.results <- panSEA::drugSEA_ties(
-    data = corr.output, gmt = gmt, drug = drug, rank.metric = rank.metric, 
-    set.type = set.type, direction.adjust = NULL, FDR = FDR, 
-    num.permutations = num.permutations, stat.type = stat.type, 
-    min.per.set = min.per.set, sep = sep, exclusions = exclusions, 
-    descriptions = descriptions, convert.synonyms = FALSE, ties = ties
-  )
-
-  return(list(
-    WV.scores = WV.result$scores,
-    unused.weights = WV.result$unused.weights,
-    corr.result = corr.results$result,
-    corr.scatter.plots = corr.results$scatter.plots,
-    gmt = gmt,
-    result = DMEA.results$result,
-    result.w.ties = DMEA.results$result.w.ties,
-    mtn.plots = DMEA.results$mtn.plots,
-    volcano.plot = DMEA.results$volcano.plot,
-    removed.sets = DMEA.results$removed.sets,
-    unannotated.drugs = DMEA.results$unannotated.drugs
-  ))
-}
diff --git a/R/DMEA_cell_corr.R b/R/DMEA_cell_corr.R
old mode 100755
new mode 100644
index f125c3f..02ac774
--- a/R/DMEA_cell_corr.R
+++ b/R/DMEA_cell_corr.R
@@ -13,7 +13,7 @@ DMEA_cell_corr <- function(drug.sensitivity, gmt = NULL, expression, weights,
                            FDR.scatter.plots = 0.05,
                            xlab = "Expression Correlation Estimate", 
                            ylab = value,
-                           position.x = "min", position.y = "min", se = TRUE, ties = FALSE) {
+                           position.x = "min", position.y = "min", se = TRUE) {
   # reformat expression data frame with cell lines as column names
   rownames(expression) <- expression[ , sample.names]
   expr <- as.data.frame(t(expression))
@@ -44,11 +44,11 @@ DMEA_cell_corr <- function(drug.sensitivity, gmt = NULL, expression, weights,
                                se = se)
   
   # run drugSEA
-  DMEA.results <- panSEA::drugSEA_ties(
+  DMEA.results <- DMEA::drugSEA(
     drug.corr$result, gmt, drug, rank.metric, set.type, FDR = FDR,
     num.permutations = num.permutations, stat.type = stat.type,
     min.per.set = min.per.set, sep = sep, exclusions = exclusions,
-    descriptions = descriptions, ties = ties
+    descriptions = descriptions
   )
 
   return(list(
diff --git a/R/DMEA_gene_corr.R b/R/DMEA_gene_corr.R
old mode 100755
new mode 100644
index 737fff7..bfecd85
--- a/R/DMEA_gene_corr.R
+++ b/R/DMEA_gene_corr.R
@@ -1,5 +1,5 @@
-DMEA_gene_corr <- function(gmt = NULL, expression, weights,
-                           value = "Perturbation", sample.names = "Drug", 
+DMEA_gene_corr <- function(drug.sensitivity, gmt = NULL, expression, weights,
+                           value = "AUC", sample.names = colnames(expression)[1], 
                            gene.names = colnames(weights)[1], 
                            weight.values = colnames(weights)[2],
                            rank.metric = "Pearson.est", FDR = 0.25,
@@ -13,39 +13,29 @@ DMEA_gene_corr <- function(gmt = NULL, expression, weights,
                            FDR.scatter.plots = 0.05,
                            xlab = "Expression Correlation Estimate", 
                            ylab = value,
-                           position.x = "min", position.y = "min", se = TRUE, ties = FALSE) {
+                           position.x = "min", position.y = "min", se = TRUE) {
   # merge expression data frame with input weights
   expr.weights <- merge(weights[ , c(gene.names, weight.values)], 
                         expression, by = gene.names)
   
-  if (nrow(na.omit(expr.weights)) > 2) {
-    # for each drug line: run correlation between expression & input weights
-    # data points are genes
-    drug.corr <- DMEA::rank_corr(expr.weights, variable = sample.names,
-                                 value = value, type = scatter.plot.type, 
-                                 min.per.corr = min.per.corr,
-                                 plots = scatter.plots, 
-                                 FDR = FDR.scatter.plots, 
-                                 xlab = xlab, ylab = ylab, 
-                                 position.x = position.x, 
-                                 position.y = position.y, se = se)
-    
-    # run drugSEA
-    DMEA.results <- panSEA::drugSEA_ties(
-      drug.corr$result, gmt, drug, rank.metric, set.type, FDR = FDR,
-      num.permutations = num.permutations, stat.type = stat.type,
-      min.per.set = min.per.set, sep = sep, exclusions = exclusions,
-      descriptions = descriptions, ties = ties
-    ) 
-  } else {
-    drug.corr <- list("result" = data.frame(),
-                      "scatter.plots" = NA)
-    DMEA.results <- list("result" = data.frame(),
-                         "mtn.plots" = list(),
-                         "volcano.plot" = list(),
-                         "removed.sets" = data.frame(),
-                         "unannotated.drugs" = data.frame())
-  }
+  # for each drug line: run correlation between expression & input weights
+  # data points are genes
+  drug.corr <- DMEA::rank_corr(expr.weights, variable = sample.names,
+                                       value = value, type = scatter.plot.type, 
+                                       min.per.corr = min.per.corr,
+                                       plots = scatter.plots, 
+                                       FDR = FDR.scatter.plots, 
+                                       xlab = xlab, ylab = ylab, 
+                                       position.x = position.x, 
+                                       position.y = position.y, se = se)
+  
+  # run drugSEA
+  DMEA.results <- DMEA::drugSEA(
+    drug.corr$result, gmt, drug, rank.metric, set.type, FDR = FDR,
+    num.permutations = num.permutations, stat.type = stat.type,
+    min.per.set = min.per.set, sep = sep, exclusions = exclusions,
+    descriptions = descriptions
+  )
 
   return(list(
     corr.result = drug.corr$result,
diff --git a/R/WV.R b/R/WV.R
deleted file mode 100755
index ccfd870..0000000
--- a/R/WV.R
+++ /dev/null
@@ -1,62 +0,0 @@
-WV <- function(expression, weights, sample.names = colnames(expression)[1],
-               gene.names = colnames(weights)[1],
-               weight.values = colnames(weights)[2]) {
-  # expression: cell lines should be rows, genes should be columns
-  # weights: one column should contain gene symbols,
-  # another column should be gene weights
-  message("Calculating Weighted Voting scores...")
-
-  # check classes of inputs are as expected
-  testthat::expect_is(expression, "data.frame")
-  testthat::expect_is(weights, "data.frame")
-
-  # remove gene names not found in expression
-  unused.weights <- weights[!(weights[, gene.names] %in%
-                                colnames(expression)[2:ncol(expression)]), ]
-  filtered.weights <- weights[weights[, gene.names] %in%
-                                colnames(expression)[2:ncol(expression)],
-                              c(gene.names, weight.values)]
-  filtered.weights <- na.omit(filtered.weights)
-
-  # check expression for gene names
-  filtered.expr <- expression %>%
-    dplyr::select(c(tidyselect::all_of(sample.names),
-                    tidyselect::all_of(filtered.weights[, gene.names])))
-  filtered.expr <- filtered.expr[,colSums(is.na(filtered.expr)) == 0]
-  filtered.weights <- filtered.weights[filtered.weights[,gene.names] %in% 
-                                         colnames(filtered.expr)[2:ncol(filtered.expr)],]
-
-  if (nrow(filtered.expr) > 0) {
-    ## prep for matrix multiplication
-    # store sample names in row names
-    rownames(filtered.expr) <- filtered.expr[, sample.names]
-
-    # remove sample names from expression
-    filtered.expr.data <- dplyr::select(filtered.expr,
-                                        -c(tidyselect::all_of(sample.names)))
-
-    # remove gene names from weights
-    weight.data <- dplyr::select(filtered.weights,
-                                 -c(tidyselect::all_of(gene.names)))
-
-    # format data frames as matrices
-    weight.matrix <- as.matrix(weight.data)
-    expr.matrix <- as.matrix(filtered.expr.data)
-
-    ## perform matrix multiplication
-    scores <- as.data.frame(expr.matrix %*% weight.matrix)
-
-    ## format dataframe for output
-    colnames(scores)[1] <- "WV"
-    scores[, c(sample.names)] <- rownames(scores)
-    scores <- scores %>% relocate(colnames(scores)[2], .before = WV)
-
-    # check classes of outputs are as expected
-    testthat::expect_is(scores, "data.frame")
-    testthat::expect_is(unused.weights, "data.frame")
-  } else {
-    stop(paste("expression data frame does not contain",
-               "any of the gene symbols provided"))
-  }
-  return(list(scores = scores, unused.weights = unused.weights))
-}
diff --git a/R/compile_mDEG.R b/R/compile_mDEG.R
old mode 100755
new mode 100644
diff --git a/R/compile_mDMEA.R b/R/compile_mDMEA.R
old mode 100755
new mode 100644
diff --git a/R/compile_mGSEA.R b/R/compile_mGSEA.R
old mode 100755
new mode 100644
index d1f1951..2da043a
--- a/R/compile_mGSEA.R
+++ b/R/compile_mGSEA.R
@@ -8,13 +8,11 @@ compile_mGSEA <- function(ssGSEA.list, p = 0.05, FDR = 0.25, n.dot.sets = 10) {
   }
 
   # collapse GSEA results across omics types
-  GSEA.df <- as.data.frame(data.table::rbindlist(GSEA.df, use.names = TRUE, idcol = "type"))
+  GSEA.df <- data.table::rbindlist(GSEA.df, use.names = TRUE, idcol = "type")
   GSEA.df$minusLogP <- -log(GSEA.df$p_value, base = 10)
   GSEA.df$minusLogFDR <- -log(GSEA.df$FDR_q_value, base = 10)
   GSEA.df$sig <- FALSE
-  if (nrow(GSEA.df[GSEA.df$p_value < p & GSEA.df$FDR_q_value < FDR, ]) > 0) {
-    GSEA.df[GSEA.df$p_value < p & GSEA.df$FDR_q_value < FDR, ]$sig <- TRUE 
-  }
+  GSEA.df[GSEA.df$p_value < p & GSEA.df$FDR_q_value < FDR, ]$sig <- TRUE
   
   # summarize results for each Feature_set
   mean.GSEA.df <- plyr::ddply(GSEA.df, .(Feature_set), summarize,
@@ -25,7 +23,7 @@ compile_mGSEA <- function(ssGSEA.list, p = 0.05, FDR = 0.25, n.dot.sets = 10) {
                               N_types = length(unique(type)),
                               N_sig = length(sig[sig]),
                               sig_types = paste0(type[sig], collapse = ", "))
-  if (length(na.omit(unique(mean.GSEA.df$Fisher_p))) > 1) {
+  if (length(unique(mean.GSEA.df$Fisher_p)) > 1) {
     mean.GSEA.df$adj_Fisher_p <- 
       qvalue::qvalue(mean.GSEA.df$Fisher_p, pi0=1)$qvalues
   } else {
@@ -47,9 +45,6 @@ compile_mGSEA <- function(ssGSEA.list, p = 0.05, FDR = 0.25, n.dot.sets = 10) {
       mean.GSEA.df %>% dplyr::slice_max(abs(mean_NES), n = n.dot.sets)
   }
   dot.df <- GSEA.df[GSEA.df$Feature_set %in% top.GSEA.df$Feature_set, ]
-  if (any(dot.df$FDR_q_value == 0)) {
-    dot.df[dot.df$FDR_q_value == 0,]$FDR_q_value <- 0.0001
-  }
 
   ## create venn diagram
   # compile significant results for each type in list
diff --git a/R/drugSAI.R b/R/drugSAI.R
deleted file mode 100755
index eceb17a..0000000
--- a/R/drugSAI.R
+++ /dev/null
@@ -1,993 +0,0 @@
-
-# load GSEA_custom function
-GSEA_custom <- function(input.df, gmt.list,
-                        nperm = 1000,
-                        stat.type = "Weighted", min.per.set,
-                        convert.synonyms = FALSE, ties = FALSE, marker.select=TRUE) {
-  GSEA.EnrichmentScore <- function(gene.list, gene.set,
-                                   weighted.score.type = score.weight,
-                                   correl.vector = NULL) {
-    tag.indicators <- sign(match(gene.list, gene.set, nomatch = 0))
-    no.tag.indicator <- 1 - tag.indicators
-    N <- length(gene.list)
-    Nh <- sum(tag.indicators)
-    Nm <- N - Nh
-    if (weighted.score.type == 0) {
-      correl.vector <- rep(1, N)
-    }
-    alpha <- weighted.score.type
-    correl.vector <- abs(correl.vector**alpha)
-    sum.correl.tag <- sum(correl.vector[tag.indicators == 1])
-    norm.tag <- 1.0 / sum.correl.tag
-    norm.no.tag <- 1.0 / Nm
-    RES <-
-      cumsum(tag.indicators * correl.vector * norm.tag -
-               no.tag.indicator * norm.no.tag)
-    max.ES <- max(RES)
-    min.ES <- min(RES)
-    if (max.ES > -min.ES) {
-      ES <- signif(max.ES, digits = 5)
-      arg.ES <- which.max(RES)
-    } else {
-      ES <- signif(min.ES, digits = 5)
-      arg.ES <- which.min(RES)
-    }
-    return(list(
-      ES = ES,
-      arg.ES = arg.ES,
-      RES = RES,
-      indicator = tag.indicators
-    ))
-  }
-  
-  # set weight for drug ranks
-  if (stat.type == "Classic") {
-    score.weight <- 0
-  } else if (stat.type == "Weighted") {
-    score.weight <- 1
-  }
-  
-  # find biggest drug set
-  biggest.set <- min.per.set
-  for (i in seq_len(length(gmt.list$genesets))) {
-    if (length(gmt.list$genesets[[i]]) > biggest.set) {
-      biggest.set <- length(gmt.list$genesets[[i]])
-    }
-  }
-  
-  # restructure drug sets so that each MOA is a column with drugs in rows
-  # also generate list of all annotated drugs from gmt
-  Drug.Sets <- matrix(
-    data = "", nrow = biggest.set,
-    ncol = length(gmt.list$genesets)
-  )
-  colnames(Drug.Sets) <- gmt.list$geneset.names
-  annotated.drugs <- c()
-  for (i in seq_len(ncol(Drug.Sets))) {
-    for (j in seq_len(length(gmt.list$genesets[[i]]))) {
-      Drug.Sets[j, i] <- gmt.list$genesets[[i]][[j]][1]
-      annotated.drugs <- c(annotated.drugs, gmt.list$genesets[[i]][[j]][1])
-    }
-  }
-  Drug.Sets <- as.data.frame(Drug.Sets)
-  annotated.drugs <- unique(annotated.drugs)
-  
-  # check class of inputs is as expected
-  testthat::expect_is(input.df, "data.frame")
-  testthat::expect_is(Drug.Sets, "data.frame")
-  
-  Samples <- colnames(input.df)[2]
-  Drug.Sets.All <- colnames(Drug.Sets)
-  
-  annotations <- matrix(
-    data = 0, nrow = nrow(input.df),
-    ncol = length(Drug.Sets.All)
-  )
-  colnames(annotations) <- Drug.Sets.All
-  
-  annotations <- as.data.frame(annotations)
-  
-  annotations <- cbind(input.df[, 1], annotations)
-  colnames(annotations) <- c(colnames(input.df)[1], Drug.Sets.All)
-  annotations <- as.matrix(annotations)
-  
-  # Find out how many cores are available
-  if (requireNamespace("parallel") &
-      requireNamespace("snow") &
-      requireNamespace("doSNOW")) {
-    cores <- parallel::detectCores()
-    if (cores[1] > 1) {
-      cl <- snow::makeCluster(cores[1] - 1) # cluster using all but 1 core
-      doSNOW::registerDoSNOW(cl) # register cluster
-    }
-  }
-  
-  num.hits.pathways <- as.data.frame(Drug.Sets.All)
-  num.hits.pathways$N_drugs <- NA
-  ### Annotate drug sets
-  for (j in seq_len(length(Drug.Sets.All))) {
-    temp.pathway <- Drug.Sets[, Drug.Sets.All[j]]
-    for (i in seq_len(nrow(annotations))) {
-      if (annotations[i, 1] %in% temp.pathway) {
-        annotations[i, j + 1] <- "X"
-      }
-    }
-    num.hits.pathways$N_drugs[j] <-
-      sum(annotations[, Drug.Sets.All[j]] == "X")
-  }
-  
-  ### Check if any drugs are not in any sets
-  unannotated.drugs <- c()
-  for (i in seq_len(nrow(annotations))) {
-    if (sum(annotations[i, 2:ncol(annotations)] == "X") == 0) {
-      unannotated.drugs <- c(unannotated.drugs, annotations[i, 1])
-    }
-  }
-  
-  ### Check if these unannotated drug names are a synonym for an annotated drug
-  if (convert.synonyms) {
-    # access drug synonyms
-    synonyms <- utils::read.csv(
-      paste0("https://raw.github.com/BelindaBGarana/DMEA/",
-             "shiny-app/Inputs/PRISM_drug_synonyms.csv")
-    )
-    replacements <- as.data.frame(unannotated.drugs)
-    replacements[, c("PRISM_drug_name",
-                     "PubChem_CID", "PubChem_synonyms")] <- NA
-    for (i in seq_len(length(unannotated.drugs))) {
-      # check if unannotated drug name is a CID for a PRISM drug
-      if (unannotated.drugs[i] %in% synonyms$PubChem_CID) {
-        replacements[i, c("PRISM_drug_name",
-                          "PubChem_CID", "PubChem_synonyms")] <-
-          synonyms[synonyms$PubChem_CID == unannotated.drugs[i], ]
-      } else {
-        # else check if unannotated drug is a synonym for a PRISM drug name
-        for (j in seq_len(nrow(synonyms))) {
-          temp.synonyms <- strsplit(synonyms$PubChem_synonyms[j], "[|]")
-          if (unannotated.drugs[i] %in% temp.synonyms) {
-            replacements[i, c("PRISM_drug_name",
-                              "PubChem_CID", "PubChem_synonyms")] <-
-              synonyms[j, c("PRISM_drug_name",
-                            "PubChem_CID", "PubChem_synonyms")]
-            break
-          }
-        }
-      }
-    }
-    unannotated.drugs <-
-      replacements[is.na(replacements$PRISM_drug_name), ]$unannotated.drugs
-    
-    # remove any drugs which were not replaced
-    replacements <- na.omit(replacements)
-    rm(synonyms)
-    
-    # replace drug names in rank list
-    for (i in seq_len(nrow(input.df))) {
-      if (input.df[i, 1] %in% replacements$unannotated.drugs) {
-        input.df[i, 1] <-
-          replacements[replacements$unannotated.drugs == input.df[i, 1],
-          ]$PRISM_drug_name
-      }
-    }
-    
-    # redo annotations
-    annotations <- matrix(
-      data = 0, nrow = nrow(input.df),
-      ncol = length(Drug.Sets.All)
-    )
-    colnames(annotations) <- Drug.Sets.All
-    
-    annotations <- as.data.frame(annotations)
-    
-    annotations <- cbind(input.df[, 1], annotations)
-    colnames(annotations) <- c(colnames(input.df)[1], Drug.Sets.All)
-    annotations <- as.matrix(annotations)
-    
-    ### Annotate drug sets
-    for (j in seq_len(length(Drug.Sets.All))) {
-      temp.pathway <- Drug.Sets[, Drug.Sets.All[j]]
-      for (i in seq_len(nrow(annotations))) {
-        if (annotations[i, 1] %in% temp.pathway) {
-          annotations[i, j + 1] <- "X"
-        }
-      }
-      num.hits.pathways$N_drugs[j] <-
-        sum(annotations[, Drug.Sets.All[j]] == "X")
-    }
-  } else {
-    replacements <- NULL
-  }
-  unannotated.input <- input.df[input.df[, 1] %in% unannotated.drugs, ]
-  
-  Drug.Sets.under <-
-    num.hits.pathways[num.hits.pathways$N_drugs < min.per.set, ]$Drug.Sets.All
-  Drug.Sets.over <-
-    num.hits.pathways[num.hits.pathways$N_drugs >= min.per.set,
-    ]$Drug.Sets.All
-  if (length(Drug.Sets.under) > 0) {
-    warning(paste0(
-      "Removing drug sets with less than ", min.per.set,
-      " drugs observed in data set"
-    ))
-    annotations <- annotations[, c(colnames(input.df)[1], Drug.Sets.All)]
-    
-    # only keep drug sets with >= min.per.set drugs
-    Drug.Sets.All <- Drug.Sets.over
-  }
-  colnames(num.hits.pathways)[1] <- "Drug_set"
-  if (length(Drug.Sets.over) < 2) {
-    stop("annotations for 2+ sets are required")
-  } # BG 2022-06-25
-  annotations <- as.data.frame(annotations)
-  input.df <- merge(input.df, annotations, by = colnames(input.df)[1])
-  input.df <- stats::na.omit(input.df)
-  rm(annotations)
-  
-  GSEA.Results <- matrix(data = NA, nrow = length(Drug.Sets.All), ncol = 8)
-  colnames(GSEA.Results) <- c(
-    "Rank_metric", "Drug_set", "ES", "NES",
-    "p_value", "Position_at_max", "FDR_q_value", "Leading_edge"
-  )
-  GSEA.Results <- as.data.frame(GSEA.Results)
-  GSEA.Results$Drug_set <- Drug.Sets.All
-  GSEA.Results$Rank_metric <- Samples
-  
-  ## Assuming first two columns in data table are drug names and
-  ## rank metric (e.g. Foldchange, SNR)
-  input.df[, Samples] <- as.numeric(as.character(input.df[, Samples]))
-  
-  # sort by descending order for the rank metric
-  input.df <- input.df[order(-input.df[, Samples]), ]
-  
-  # reorder row indices for counting in for loop below
-  rownames(input.df) <- seq_len(nrow(input.df))
-  ions <- nrow(input.df)
-  
-  # for plotting
-  ks_results_plot <- list()
-  positions.of.hits <- list()
-  
-  gene.list <- seq_len(ions)
-  rank_metric <- input.df[, Samples] # Save the rank metric
-  
-  pos_gene_set <- array(data = 0, dim = nrow(input.df), dimnames = NULL)
-  
-  ## Calculate Real KS Statistic with original input
-  message("calculating ES with original input")
-  for (i in seq_len(length(Drug.Sets.All))) {
-    pos_gene_set <- which(input.df[, Drug.Sets.All[i]] %in% c("X"))
-    KS_real <- GSEA.EnrichmentScore(gene.list, pos_gene_set,
-                                    weighted.score.type = score.weight,
-                                    correl.vector = rank_metric
-    )
-    
-    # store ES and positions
-    GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i],
-    ]$ES <- KS_real$ES
-    GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i],
-    ]$Position_at_max <- KS_real$arg.ES
-    ks_results_plot[[Drug.Sets.All[i]]] <- KS_real$RES
-    positions.of.hits[[Drug.Sets.All[i]]] <- pos_gene_set
-    
-    # identify leading edge elements
-    if (KS_real$ES <= 0) {
-      pos_leading_edge <- pos_gene_set[pos_gene_set >= KS_real$arg.ES]
-    } else if (KS_real$ES >= 0) {
-      pos_leading_edge <- pos_gene_set[pos_gene_set <= KS_real$arg.ES]
-    }
-    leading_edge <- input.df[pos_leading_edge, 1]
-    GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i], 
-    ]$Leading_edge <- paste(leading_edge, collapse = ", ")
-  }
-  Mountain.Plot.Info <- list(
-    MountainPlot = ks_results_plot,
-    Position.of.hits = positions.of.hits
-  )
-  rm(pos_gene_set)
-  rm(KS_real)
-  
-  ### tie permutations (NOT a null distribution)
-  if (ties) {
-    KSRandomArray_ties <- matrix(data = NA, nrow = nperm,
-                                 ncol = length(Drug.Sets.All))
-    num.Drug.Sets.all <- length(Drug.Sets.All)
-    `%dopar%` <- foreach::`%dopar%`
-    message("calculating ES with shuffled ties")
-    KSRandomArray_ties <- foreach::foreach(L = seq_len(nperm),
-                                           .combine = "rbind") %dopar% {
-                                             # randomly jitter list to shuffle ties
-                                             temp.input <- input.df[order(-input.df[, Samples], jitter(-input.df[, Samples])),]
-                                             rownames(temp.input) <- seq_len(nrow(temp.input)) # adding in case random result is due to nonsequential rownames?
-                                             gene.list <- rownames(temp.input)
-                                             
-                                             temp.KSRandomArray <- matrix(data = NA, nrow = 1,
-                                                                          ncol = num.Drug.Sets.all)
-                                             for (i in seq_len(length(Drug.Sets.All))) {
-                                               pos_gene_set <- which(temp.input[, Drug.Sets.All[i]] %in% c("X"))
-                                               
-                                               # calculate ES with shuffled ties
-                                               temp.KSRandomArray[, i] <- GSEA.EnrichmentScore(gene.list,
-                                                                                               pos_gene_set,
-                                                                                               weighted.score.type = score.weight,
-                                                                                               correl.vector = temp.input[, Samples]
-                                               )$ES
-                                             }
-                                             temp.KSRandomArray
-                                           }
-    colnames(KSRandomArray_ties) <- Drug.Sets.All
-    KSRandomArray_ties <- as.data.frame(KSRandomArray_ties)
-    
-    ### calculate ES & NES
-    # let ES = mean of ES tie distribution and NES = mean of NES tie distribution
-    GSEA.Results.ties <- matrix(data = NA, nrow = length(Drug.Sets.All), ncol = 11)
-    colnames(GSEA.Results.ties) <- c(
-      "Rank_metric", "Drug_set", "ES","ES_min","ES_max", "ES_sd",
-      "NES", "NES_min", "NES_max", "p_value", "FDR_q_value"
-    )
-    GSEA.Results.ties <- as.data.frame(GSEA.Results.ties)
-    GSEA.Results.ties$Drug_set <- Drug.Sets.All
-    GSEA.Results.ties$Rank_metric <- Samples
-    GSEA.Results.ties$ES <- colMeans(KSRandomArray_ties, na.rm = TRUE)
-    GSEA.Results.ties$ES_min <- apply(KSRandomArray_ties, 2, min)
-    GSEA.Results.ties$ES_max <- apply(KSRandomArray_ties, 2, max)
-    GSEA.Results.ties$ES_sd <- apply(KSRandomArray_ties, 2, sd)
-    percent.pos.GSEA.ties <- sum(GSEA.Results.ties$ES >= 0) /
-      length(GSEA.Results.ties$ES) # BG OR EQUAL TO
-    percent.neg.GSEA.ties <- sum(GSEA.Results.ties$ES <= 0) /
-      length(GSEA.Results.ties$ES) # BG OR EQUAL TO 
-  }
-  
-  ### optional: weight permutations (for biomarker selection)
-  if (marker.select) {
-    KSMarkerArray <- matrix(data = NA, nrow = nperm,
-                            ncol = length(Drug.Sets.All))
-    num.Drug.Sets.all <- length(Drug.Sets.All)
-    `%dopar%` <- foreach::`%dopar%`
-    
-    KSMarkerArray <- foreach::foreach(L = seq_len(ncol(marker.perms)),
-                                      .combine = "rbind") %dopar% {
-                                        temp.KSMarkerArray <- matrix(data = NA, nrow = 1,
-                                                                     ncol = num.Drug.Sets.all)
-                                        for (i in seq_len(length(Drug.Sets.All))) {
-                                          pos_gene_set <- which(temp.input[, Drug.Sets.All[i]] %in% c("X"))
-                                          
-                                          # calculate enrichment score for each drug set and rank list which excluded each gene
-                                          temp.KSMarkerArray[, i] <- GSEA.EnrichmentScore(marker.perms[,L],
-                                                                                          pos_gene_set,
-                                                                                          weighted.score.type = score.weight,
-                                                                                          correl.vector = rank_metric
-                                          )$ES
-                                        }
-                                        temp.KSMarkerArray
-                                      }
-    colnames(KSMarkerArray) <- Drug.Sets.All
-    KSMarkerArray <- as.data.frame(KSMarkerArray) 
-    
-    markerDiff <- KSMarkerArray - GSEA.Results$ES # check this will subtract first ES from first column values
-  } else{ #SG Added to avoid error
-    markerDiff <- rep(0,nrow(GSEA.Results))
-  }
-  
-  ### MOA permutations (null distribution)
-  KSRandomArray <- matrix(data = NA, nrow = nperm,
-                          ncol = length(Drug.Sets.All))
-  num.Drug.Sets.all <- length(Drug.Sets.All)
-  `%dopar%` <- foreach::`%dopar%`
-  
-  KSRandomArray <- foreach::foreach(L = seq_len(nperm),
-                                    .combine = "rbind") %dopar% {
-                                      temp.KSRandomArray <- matrix(data = NA, nrow = 1,
-                                                                   ncol = num.Drug.Sets.all)
-                                      for (i in seq_len(length(Drug.Sets.All))) {
-                                        # randomly sample drug set of same size as original set
-                                        numhits_pathway <- length(positions.of.hits[[Drug.Sets.All[i]]])
-                                        pos_gene_set <- sample(seq_len(ions), numhits_pathway)
-                                        
-                                        # calculate null enrichment score
-                                        temp.KSRandomArray[, i] <- GSEA.EnrichmentScore(gene.list,
-                                                                                         pos_gene_set,
-                                                                                         weighted.score.type = score.weight,
-                                                                                         correl.vector = rank_metric
-                                        )$ES
-                                      }
-                                      temp.KSRandomArray
-                                    }
-  colnames(KSRandomArray) <- Drug.Sets.All
-  KSRandomArray <- as.data.frame(KSRandomArray)
-  
-  ### normalize the GSEA distribution
-  KSRandomArray.Norm <- matrix(
-    data = NA, nrow = nrow(KSRandomArray),
-    ncol = ncol(KSRandomArray)
-  )
-  colnames(KSRandomArray.Norm) <- colnames(KSRandomArray)
-  KSRandomArray.temp <- 0
-  for (i in seq_len(ncol(KSRandomArray.Norm))) {
-    KSRandomArray.temp <- KSRandomArray[, i]
-    pos.temp <- KSRandomArray.temp[which(KSRandomArray.temp >= 0)]
-    neg.temp <-
-      KSRandomArray.temp[which(KSRandomArray.temp <= 0)] # BG OR EQUAL TO
-    
-    avg.pos <- mean(pos.temp)
-    avg.neg <- mean(neg.temp)
-    
-    norm.pos.temp <- pos.temp / avg.pos
-    norm.neg.temp <- neg.temp / avg.neg * -1
-    
-    norm.perms <- c(norm.pos.temp, norm.neg.temp)
-    
-    KSRandomArray.Norm[, i] <- norm.perms
-  }
-  GSEA.NES.perms <- as.vector(KSRandomArray.Norm)
-  rm(KSRandomArray.Norm)
-  GSEA.NES.perms.pos <- GSEA.NES.perms[which(GSEA.NES.perms >= 0)]
-  GSEA.NES.perms.neg <-
-    GSEA.NES.perms[which(GSEA.NES.perms <= 0)] # BG OR EQUAL TO
-  rm(GSEA.NES.perms)
-  percent.pos.GSEA <- sum(GSEA.Results$ES >= 0) /
-    length(GSEA.Results$ES) # BG OR EQUAL TO
-  percent.neg.GSEA <- sum(GSEA.Results$ES <= 0) /
-    length(GSEA.Results$ES) # BG OR EQUAL TO
-  
-  # Calculate GSEA NES and p-value
-  for (i in seq_len(length(Drug.Sets.All))) {
-    temp.gene.set <- Drug.Sets.All[i]
-    temp.perms <- KSRandomArray[, temp.gene.set]
-    temp.ES <- GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$ES
-    if (ties) {
-      temp.ES.tie <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES
-      temp.ES.tie.min <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES_min
-      temp.ES.tie.max <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES_max 
-    }
-    pos.perms <- temp.perms[which(temp.perms >= 0)] # BG OR EQUAL TO
-    neg.perms <- temp.perms[which(temp.perms <= 0)] # BG OR EQUAL TO
-    
-    # original input order
-    if (temp.ES >= 0) { # BG OR EQUAL TO
-      # p-value
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <-
-        signif(sum(pos.perms >= temp.ES) /
-                 length(pos.perms), digits = 3) # BG OR EQUAL TO
-      
-      # NES
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES <-
-        signif(temp.ES / mean(pos.perms), digits = 3)
-    } else { # BG OR EQUAL TO
-      # p-value
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <-
-        signif(sum(neg.perms <= temp.ES) /
-                 length(neg.perms), digits = 3) # BG OR EQUAL TO
-      
-      # NES
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES <-
-        signif(temp.ES / mean(neg.perms) * -1, digits = 3)
-    }
-    
-    # shuffled ties
-    if (ties) {
-      if (temp.ES.tie >= 0) {
-        # p-value
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$p_value <-
-          signif(sum(pos.perms >= temp.ES.tie.min) /
-                   length(pos.perms), digits = 3)
-        
-        # NES
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES <-
-          signif(temp.ES.tie / mean(pos.perms), digits = 3)
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min <-
-          signif(temp.ES.tie.min / mean(pos.perms), digits = 3)
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max <-
-          signif(temp.ES.tie.max / mean(pos.perms), digits = 3)
-      } else { # BG OR EQUAL TO
-        # p-val
-        GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <-
-          signif(sum(neg.perms <= temp.ES) /
-                   length(neg.perms), digits = 3) # BG OR EQUAL TO
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$p_value <-
-          signif(sum(neg.perms <= temp.ES.tie.max) /
-                   length(neg.perms), digits = 3)
-        
-        # NES
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES <-
-          signif(temp.ES.tie / mean(neg.perms) * -1, digits = 3)
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min <-
-          signif(temp.ES.tie.min / mean(neg.perms) * -1, digits = 3)
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max <-
-          signif(temp.ES.tie.max / mean(neg.perms) * -1, digits = 3)
-      } 
-    }
-  }
-  
-  # Calculate GSEA FDR
-  for (i in seq_len(length(Drug.Sets.All))) {
-    temp.gene.set <- Drug.Sets.All[i]
-    temp.NES <- GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES
-    if (ties) {
-      temp.NES.tie <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES
-      temp.NES.tie.min <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min
-      temp.NES.tie.max <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max 
-    }
-    
-    # results for original input
-    if (temp.NES >= 0) { # BG OR EQUAL TO
-      percent.temp <-
-        sum(GSEA.NES.perms.pos >=
-              GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES) /
-        length(GSEA.NES.perms.pos) # BG OR EQUAL TO
-      percent.pos.stronger <-
-        sum(GSEA.Results$NES >=
-              GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES) /
-        sum(GSEA.Results$NES >= 0) # BG
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$FDR_q_value <-
-        ifelse(signif(percent.temp / percent.pos.stronger, digits = 3) < 1,
-               signif(percent.temp / percent.pos.stronger, digits = 3), 1
-        ) # BG
-    } else { # BG OR EQUAL TO
-      percent.temp <- sum(GSEA.NES.perms.neg <= temp.NES) /
-        length(GSEA.NES.perms.neg) # BG OR EQUAL TO
-      percent.neg.stronger <- sum(GSEA.Results$NES <= temp.NES) /
-        sum(GSEA.Results$NES <= 0) # BG
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$FDR_q_value <-
-        ifelse(signif(percent.temp / percent.neg.stronger, digits = 3) < 1,
-               signif(percent.temp / percent.neg.stronger, digits = 3), 1
-        ) # BG
-    }
-    
-    # results for shuffled ties
-    if (ties) {
-      if (temp.NES.tie >= 0) {
-        percent.temp <-
-          sum(GSEA.NES.perms.pos >= temp.NES.tie.min) / length(GSEA.NES.perms.pos) # BG OR EQUAL TO
-        percent.pos.stronger <-
-          sum(GSEA.Results.ties$NES_max >= temp.NES.tie.min) / sum(GSEA.Results.ties$NES >= 0) # BG
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$FDR_q_value <-
-          ifelse(signif(percent.temp / percent.pos.stronger, digits = 3) < 1,
-                 signif(percent.temp / percent.pos.stronger, digits = 3), 1
-          ) # BG
-      } else {
-        percent.temp <- sum(GSEA.NES.perms.neg <= temp.NES.tie.max) / length(GSEA.NES.perms.neg) # BG OR EQUAL TO
-        percent.neg.stronger <- sum(GSEA.Results.ties$NES_min <= temp.NES.tie.max) / sum(GSEA.Results.ties$NES <= 0) # BG
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$FDR_q_value <-
-          ifelse(signif(percent.temp / percent.neg.stronger, digits = 3) < 1,
-                 signif(percent.temp / percent.neg.stronger, digits = 3), 1
-          ) # BG
-      } 
-    }
-  }
-  
-  if (requireNamespace("parallel") &
-      requireNamespace("snow") &
-      requireNamespace("doSNOW")) {
-    if (cores[1] > 1) {
-      snow::stopCluster(cl) # stop cluster
-      rm(cl)
-    }
-  }
-  
-  if (!ties) {
-    GSEA.Results.ties <- data.frame()
-  }
-  
-  return(list(
-    GSEA.Results = GSEA.Results,
-    GSEA.Results.ties = GSEA.Results.ties,
-    Mountain.Plot.Info = Mountain.Plot.Info,
-    ranking.metric = rank_metric,
-    removed.sets =
-      num.hits.pathways[num.hits.pathways$N_drugs < min.per.set, ],
-    replacements = replacements,
-    unannotated.drugs = unannotated.input,
-    marker.importance = markerDiff
-  ))
-}
-
-# load mountain plot function
-gsea_mountain_plot <- function(GSEA.list, Sample.Name, Gene.Set.A,
-                               color = TRUE) {
-  if (color) {
-    color.palette <- c("red")
-  } else if (!color) {
-    color.palette <- c("black")
-  }
-  
-  GSEA.list <- GSEA.list
-  plotting.info <- GSEA.list$Mountain.Plot.Info
-  ES_profiles <- plotting.info$MountainPlot
-  position.of.hits <- plotting.info$Position.of.hits
-  
-  ranking.metric <- as.numeric(GSEA.list$ranking.metric)
-  
-  ES_GeneSetA <- ES_profiles[[Gene.Set.A]]
-  
-  pos.GeneSetA <- position.of.hits[[Gene.Set.A]]
-  
-  myName <- Gene.Set.A
-  
-  GSEA.results <- GSEA.list$GSEA.Results
-  GSEA.results <- GSEA.results[GSEA.results$Rank_metric == Sample.Name, ]
-  GSEA.results$p_value <- as.numeric(as.character(GSEA.results$p_value))
-  GSEA.results$FDR_q_value <- as.numeric(as.character(GSEA.results$FDR_q_value))
-  
-  gsea.normalized.enrichment.score <-
-    signif(GSEA.results[GSEA.results$Drug_set == myName, ]$NES, digits = 3)
-  gsea.p.value <-
-    signif(GSEA.results[GSEA.results$Drug_set == myName, ]$p_value,
-           digits = 3)
-  gsea.q.val <-
-    signif(GSEA.results[GSEA.results$Drug_set == myName, ]$FDR_q_value,
-           digits = 3)
-  
-  results.as.text <- paste(
-    "NES", gsea.normalized.enrichment.score, "\np-value:", gsea.p.value,
-    "\nq-value:", gsea.q.val
-  )
-  
-  gsea.hit.indices.A <- pos.GeneSetA
-  
-  gsea.es.profile.A <- ES_GeneSetA[gsea.hit.indices.A]
-  
-  ngenes <- length(ES_GeneSetA)
-  combined.ES <- c(ES_GeneSetA)
-  max.ES <- max(combined.ES)
-  min.ES <- min(combined.ES)
-  
-  mtn.plot <- NULL
-  mtn.plot <- ggplot2::ggplot() +
-    ggplot2::geom_line(
-      ggplot2::aes(
-        x = c(0, pos.GeneSetA, ngenes),
-        y = c(0, gsea.es.profile.A, 0)
-      ),
-      color = color.palette[1], size = 1
-    ) +
-    ggplot2::labs(x = NULL, y = "ES", title = myName) +
-    ggplot2::scale_x_continuous(expand = c(0, 0)) +
-    ggplot2::theme_bw() +
-    ggplot2::geom_hline(yintercept = 0, linetype = "dashed",
-                        color = "grey50") +
-    ggplot2::theme(
-      axis.text.x = ggplot2::element_blank(),
-      axis.ticks.x = ggplot2::element_blank(),
-      axis.ticks.length = ggplot2::unit(0, "pt"),
-      axis.title.x = ggplot2::element_blank(),
-      panel.grid = ggplot2::element_blank(),
-      plot.background = ggplot2::element_blank(),
-      plot.margin = ggplot2::unit(c(0, 0, 0, 0), "cm"),
-      plot.title = ggplot2::element_text(hjust = 0.5)
-    )
-  
-  if (!is.null(gsea.normalized.enrichment.score) &
-      length(gsea.normalized.enrichment.score) > 0) {
-    if (gsea.normalized.enrichment.score > 0) {
-      mtn.plot <- mtn.plot + ggplot2::annotate("text",
-                                               label = results.as.text, x = ngenes * 0.90,
-                                               y = max.ES * 0.70, color = "black"
-      )
-    } else if (gsea.normalized.enrichment.score < 0) {
-      mtn.plot <- mtn.plot + ggplot2::annotate("text",
-                                               label = results.as.text, x = ngenes * 0.10,
-                                               y = min.ES * 0.30, color = "black"
-      )
-    }
-  }
-  
-  hit.markers <- ggplot2::ggplot() +
-    cowplot::theme_nothing() +
-    ggplot2::theme(panel.border = ggplot2::element_rect(color = "black",
-                                                        fill = NA)) +
-    ggplot2::geom_col(ggplot2::aes(x = pos.GeneSetA, y = 1),
-                      color = color.palette[1],
-                      fill = color.palette[1], width = 0.75
-    ) +
-    ggplot2::labs(x = NULL, y = NULL) +
-    ggplot2::scale_y_continuous(expand = c(0, 0)) +
-    aplot::xlim2(mtn.plot)
-  
-  show.rank.metric <- ggplot2::ggplot() +
-    ggplot2::geom_line(ggplot2::aes(
-      x = seq_len(ngenes),
-      y = ranking.metric
-    ), color = "grey50") +
-    ggplot2::geom_area(ggplot2::aes(
-      x = seq_len(ngenes),
-      y = ranking.metric
-    ), fill = "grey50") +
-    ggplot2::labs(x = "Rank", y = "Rank Metric") +
-    ggplot2::theme_bw() +
-    ggplot2::theme(
-      panel.grid = ggplot2::element_blank(),
-      plot.title = ggplot2::element_blank(),
-      plot.margin = ggplot2::unit(c(0, 0, 0, 0), "cm")
-    ) +
-    aplot::xlim2(mtn.plot)
-  
-  assembled <- mtn.plot + hit.markers + show.rank.metric +
-    patchwork::plot_layout(ncol = 1, heights = c(2.5, 0.5, 2))
-  return(assembled)
-}
-
-summaryPlots <- function(EA, FDR = 0.25, n.top = 10, est.name = "Pearson.est", ties = FALSE) {
-  if (ties) {
-    plot.data <- EA$GSEA.Results.ties
-    significant.hits <- EA$GSEA.Results.ties[which(EA$GSEA.Results.ties$FDR_q_value < FDR), ]
-  } else {
-    plot.data <- EA$GSEA.Results 
-    significant.hits <- EA$GSEA.Results[which(EA$GSEA.Results$FDR_q_value < FDR), ]
-  }
-  
-  if (nrow(plot.data[plot.data$p_value == 0, ]) > 0) {
-    plot.data[plot.data$p_value == 0, ]$p_value <- 0.00099
-  }
-  
-  if (nrow(plot.data[plot.data$FDR_q_value == 0, ]) > 0) {
-    plot.data[plot.data$FDR_q_value == 0, ]$FDR_q_value <- 0.00099
-  }
-  
-  # define x, y limits
-  limit.x <- ceiling(max(abs(as.numeric(plot.data$NES)), na.rm = TRUE))
-  limit.y <- ceiling(max(-as.numeric(log(plot.data$p_value, 10)), na.rm = TRUE))
-  
-  ## select results which meet FDR threshold and produce mountain plots
-  temp.plot <- list()
-  if (nrow(significant.hits) > 0) {
-    for (i in seq_len(nrow(significant.hits))) {
-      temp <- gsea_mountain_plot(
-        GSEA.list = EA, Sample.Name = est.name,
-        Gene.Set.A = significant.hits$Drug_set[i]
-      )
-      temp.plot[significant.hits$Drug_set[i]] <- list(temp)
-    }
-  } else {
-    warning("No enrichments met the FDR cut-off to produce mountain plots")
-  }
-  
-  # categorize data by significance level if there are significant hits
-  if (nrow(significant.hits) > 0) {
-    plot.data$Significance <- paste0("FDR > ", FDR)
-    plot.data[plot.data$FDR_q_value < FDR, ]$Significance <- paste0("FDR < ", FDR)
-    plot.data$Significance <- factor(plot.data$Significance,
-                                     levels = c(paste0("FDR < ", FDR),
-                                                paste0("FDR > ", FDR)))
-    bar.data <- plot.data %>% slice_max(abs(NES), n=n.top)
-    bar.data <- bar.data[order(bar.data$NES),]
-    
-    volc <- ggplot2::ggplot(data = plot.data, aes(
-      x = NES, y = -log(p_value, 10),
-      color = Significance
-    )) +
-      ggplot2::geom_point(size = 4) +
-      ggrepel::geom_text_repel(
-        data = subset(plot.data, Significance == paste0("FDR < ", FDR)),
-        mapping = aes(label = Drug_set, size = I(6)), nudge_y = 0.25
-      ) +
-      ggplot2::scale_color_manual(
-        values = c("red", "azure4"), name = "Significance",
-        breaks = c(paste0("FDR < ", FDR), paste0("FDR > ", FDR))
-      ) +
-      ggplot2::xlim(-limit.x, limit.x) +
-      ggplot2::ylim(0, limit.y) +
-      ggplot2::xlab("Normalized Enrichment Score") +
-      ggplot2::ylab("-Log(p-value)") +
-      ggplot2::geom_vline(xintercept = 0, linetype = "solid", color = "grey",
-                          linewidth = 0.5) +
-      ggplot2::theme(
-        panel.border = element_rect(colour = "black", fill = NA, linewidth = 1),
-        axis.line = element_line(colour = "black", linewidth = 0.65),
-        legend.text = element_text(size = 20),
-        axis.text = element_text(size = 20),
-        axis.title = element_text(size = 26, face = "bold"),
-        panel.background = element_rect(
-          fill = "white", colour = "white", linewidth = 0.5,
-          linetype = "solid", color = "black"
-        ), text = element_text(size = 20),
-        legend.position = "bottom", legend.key = element_blank()
-      )
-    
-    bar <- ggplot2::ggplot(bar.data, aes(x=NES, y=Drug_set, fill = Significance)) + 
-      geom_bar(stat='identity') + ggplot2::theme(
-        panel.border = element_rect(colour = "black", fill = NA, linewidth = 1),
-        axis.line = element_line(colour = "black", linewidth = 0.65),
-        legend.text = element_text(size = 20),
-        axis.text = element_text(size = 20),
-        axis.title = element_text(size = 26, face = "bold"),
-        panel.background = element_rect(
-          fill = "white", colour = "white", linewidth = 0.5,
-          linetype = "solid", color = "black"
-        ), text = element_text(size = 20),
-        legend.position = "bottom", legend.key = element_blank()
-      ) + ggplot2::xlab("Normalized Enrichment Score") + 
-      ggplot2::ylab("") +
-      ggplot2::scale_fill_manual(
-        values = c("red", "azure4"), name = "Significance",
-        breaks = c(paste0("FDR < ", FDR), paste0("FDR > ", FDR))
-      ) 
-  } else {
-    plot.data$Significance <- paste0("FDR > ", FDR)
-    plot.data$Significance <- factor(plot.data$Significance,
-                                     levels = paste0("FDR > ", FDR))
-    bar.data <- plot.data %>% slice_max(abs(NES), n=n.top)
-    bar.data <- bar.data[order(bar.data$NES),]
-    
-    volc <- ggplot2::ggplot(data = plot.data,
-                            aes(x = NES, y = -log(p_value, 10))) +
-      ggplot2::geom_point(size = 4, color = "azure4") +
-      ggplot2::xlim(-limit.x, limit.x) +
-      ggplot2::ylim(0, limit.y) +
-      ggplot2::xlab("Normalized Enrichment Score") +
-      ggplot2::ylab("-Log(p-value)") +
-      ggplot2::geom_vline(xintercept = 0, linetype = "solid", color = "grey",
-                          linewidth = 0.5) +
-      ggplot2::theme(
-        panel.border = element_rect(colour = "black", fill = NA, linewidth = 1),
-        axis.line = element_line(colour = "black", linewidth = 0.65),
-        legend.text = element_text(size = 20),
-        axis.text = element_text(size = 20),
-        axis.title = element_text(size = 26, face = "bold"),
-        panel.background = element_rect(
-          fill = "white", colour = "white", linewidth = 0.5,
-          linetype = "solid", color = "black"
-        ), text = element_text(size = 20),
-        legend.position = "bottom", legend.key = element_blank()
-      )
-    
-    bar <- ggplot2::ggplot(bar.data, aes(x=NES, y=Drug_set, fill = Significance)) + 
-      geom_bar(stat='identity') + ggplot2::theme(
-        panel.border = element_rect(colour = "black", fill = NA, linewidth = 1),
-        axis.line = element_line(colour = "black", linewidth = 0.65),
-        legend.text = element_text(size = 20),
-        axis.text = element_text(size = 20),
-        axis.title = element_text(size = 26, face = "bold"),
-        panel.background = element_rect(
-          fill = "white", colour = "white", linewidth = 0.5,
-          linetype = "solid", color = "black"
-        ), text = element_text(size = 20),
-        legend.position = "bottom", legend.key = element_blank()
-      ) + ggplot2::xlab("Normalized Enrichment Score") + 
-      ggplot2::ylab("") +
-      ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) +
-      ggplot2::scale_fill_manual(
-        values = c("azure4"), name = "Significance",
-        breaks = c(paste0("FDR > ", FDR))
-      ) 
-  }
-  bar.data$name <- est.name
-  bg.theme <- ggplot2::theme(
-    legend.background = element_rect(), legend.position = "top",
-    legend.text = element_text(size = 14),
-    legend.key = element_blank(),
-    legend.title = element_text(size = 16),
-    axis.title.x = element_text(size = 20),
-    axis.text.x = element_text(size = 16, colour = "black"),
-    axis.title.y = element_text(size = 20),
-    axis.text.y = element_text(size = 16, colour = "black"),
-    plot.title = element_text(
-      lineheight = .8, face = "bold", size = 36
-    ),
-    panel.grid.major = element_blank(),
-    panel.grid.minor = element_blank(),
-    panel.border = element_rect(fill = NA),
-    panel.background = element_blank(),
-    axis.line = element_line(colour = "black"),
-    axis.ticks.x = element_line(colour = "black"),
-    axis.ticks.y = element_line(colour = "black")
-  )
-  dot <- ggplot2::ggplot(
-    bar.data,
-    ggplot2::aes(x = name, y = Drug_set, color = NES,
-      size = -log10(FDR_q_value)
-    )
-  ) +
-    ggplot2::geom_point() +
-    ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) +
-    viridis::scale_color_viridis() +
-    bg.theme +
-    ggplot2::labs(
-      x = "", y = "",
-      color = "NES", size = "-log(FDR)"
-    )
-  
-  if (ties) {
-    dot.sd <- ggplot2::ggplot(
-      bar.data,
-      ggplot2::aes(x = name, y = Drug_set, color = NES,
-                   size = -log10(ES_sd)
-      )
-    ) +
-      ggplot2::geom_point() +
-      ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) +
-      viridis::scale_color_viridis() +
-      bg.theme +
-      ggplot2::labs(
-        x = "", y = "",
-        color = "NES", size = "-log(ES SD)"
-      ) 
-  } else {
-    dot.sd <- NA
-  }
-  return(list(volcano = volc, bar = bar, mtn = temp.plot, dot = dot, dot.sd = dot.sd))
-}
-
-drugSAI <- function(data, gmt = NULL, drug = "Drug",
-                    rank.metric = "Pearson.est", set.type = "moa",
-                    direction.adjust = NULL, FDR = 0.25,
-                    num.permutations = 1000, stat.type = "Weighted",
-                    min.per.set = 6, n.top = 10, sep = "[|]",
-                    exclusions = c("-666", "NA", "na", "NaN", "NULL"),
-                    descriptions = NULL, convert.synonyms = FALSE, plots = TRUE, 
-                    ties = FALSE, marker.select=TRUE) {
-  # avoid unclear initialization
-  Drug_set <- NULL
-  NES <- NULL
-  Significance <- NULL
-  p_value <- NULL
-
-  # check class of input is as expected
-  testthat::expect_is(data, "data.frame")
-
-  ## remove any drugs with rank.metric = 0, NA
-  ## because signed ranks are required for enrichment analysis
-  data[, c(rank.metric)] <- as.numeric(data[, c(rank.metric)])
-  data <- data[data[, c(rank.metric)] != 0 & !is.na(data[, c(rank.metric)]), ]
-
-  ## check for duplicate entries for each drug
-  ## because only 1 rank metric is allowed per drug
-  drug.names <- unique(data[, c(drug)])
-  if (length(drug.names) < nrow(data)) {
-    stop("each drug must have only 1 rank.metric value")
-  }
-
-  ## if necessary, generate gmt object
-  if (is.null(gmt)) {
-    gmt <- as_gmt(data,
-      element.names = drug, set.names = set.type,
-      min.per.set, sep, exclusions, descriptions
-    )
-  }
-
-  ## if necessary, adjust rank metrics
-  if (length(direction.adjust) > 0) {
-    info <- dplyr::distinct(data[, c(drug, rank.metric, set.type)])
-    info$adjust <- 1
-    info[grep(direction.adjust, info[, c(set.type)],
-              value = TRUE), "adjust"] <- -1
-    info$adjusted.est <-
-      as.numeric(info[, c(rank.metric)]) * as.numeric(info$adjust)
-    input <- info[, c(drug, "adjusted.est")]
-    est.name <- paste0(rank.metric, " direction-adjusted")
-  } else {
-    input <- data[, c(drug, rank.metric)]
-    est.name <- rank.metric
-  }
-  colnames(input) <- c(drug, est.name)
-
-  ## perform enrichment analysis using GSEA_custom
-  message("Running enrichment analysis...")
-  EA <- GSEA_custom(
-    input, gmt, num.permutations, stat.type,
-    min.per.set, convert.synonyms, ties, marker.select
-  )
-  if (ties) {
-    result <- EA$GSEA.Results.ties
-    result.w.ties <- EA$GSEA.Results
-  } else {
-    result <- EA$GSEA.Results
-    result.w.ties <- data.frame()
-  }
-  
-  if (plots) {
-    ## produce volcano and bar plots
-    sumPlots <- summaryPlots(EA, FDR = FDR, n.top = n.top, est.name = est.name, ties = ties) 
-  } else {
-    sumPlots <- list("volcano" = NA, "bar" = NA, "mtn" = NA)
-  }
-
-  return(list(
-    gmt = gmt, result = result, result.w.ties = result.w.ties, 
-    mtn.plots = sumPlots$mtn,
-    volcano.plot = sumPlots$volcano, bar.plot = sumPlots$bar,
-    dot.plot = sumPlots$dot, dot.sd = sumPlots$dot.sd,
-    removed.sets = EA$removed.sets,
-    replaced.drugs = EA$replacements,
-    unannotated.drugs = EA$unannotated.drugs
-  ))
-}
diff --git a/R/drugSEA_ties.R b/R/drugSEA_ties.R
deleted file mode 100755
index f9a7f4e..0000000
--- a/R/drugSEA_ties.R
+++ /dev/null
@@ -1,962 +0,0 @@
-
-# load GSEA_custom function
-GSEA_custom1 <- function(input.df, gmt.list,
-                        nperm = 1000,
-                        stat.type = "Weighted", min.per.set,
-                        convert.synonyms = FALSE, ties = FALSE) {
-  GSEA.EnrichmentScore <- function(gene.list, gene.set,
-                                   weighted.score.type = score.weight,
-                                   correl.vector = NULL) {
-    tag.indicators <- sign(match(gene.list, gene.set, nomatch = 0))
-    no.tag.indicator <- 1 - tag.indicators
-    N <- length(gene.list)
-    Nh <- sum(tag.indicators)
-    Nm <- N - Nh
-    if (weighted.score.type == 0) {
-      correl.vector <- rep(1, N)
-    }
-    alpha <- weighted.score.type
-    correl.vector <- abs(correl.vector**alpha)
-    sum.correl.tag <- sum(correl.vector[tag.indicators == 1])
-    norm.tag <- 1.0 / sum.correl.tag
-    norm.no.tag <- 1.0 / Nm
-    RES <-
-      cumsum(tag.indicators * correl.vector * norm.tag -
-               no.tag.indicator * norm.no.tag)
-    max.ES <- max(RES)
-    min.ES <- min(RES)
-    if (max.ES > -min.ES) {
-      ES <- signif(max.ES, digits = 5)
-      arg.ES <- which.max(RES)
-    } else {
-      ES <- signif(min.ES, digits = 5)
-      arg.ES <- which.min(RES)
-    }
-    return(list(
-      ES = ES,
-      arg.ES = arg.ES,
-      RES = RES,
-      indicator = tag.indicators
-    ))
-  }
-  
-  # set weight for drug ranks
-  if (stat.type == "Classic") {
-    score.weight <- 0
-  } else if (stat.type == "Weighted") {
-    score.weight <- 1
-  }
-  
-  # find biggest drug set
-  biggest.set <- min.per.set
-  for (i in seq_len(length(gmt.list$genesets))) {
-    if (length(gmt.list$genesets[[i]]) > biggest.set) {
-      biggest.set <- length(gmt.list$genesets[[i]])
-    }
-  }
-  
-  # restructure drug sets so that each MOA is a column with drugs in rows
-  # also generate list of all annotated drugs from gmt
-  Drug.Sets <- matrix(
-    data = "", nrow = biggest.set,
-    ncol = length(gmt.list$genesets)
-  )
-  colnames(Drug.Sets) <- gmt.list$geneset.names
-  annotated.drugs <- c()
-  for (i in seq_len(ncol(Drug.Sets))) {
-    for (j in seq_len(length(gmt.list$genesets[[i]]))) {
-      Drug.Sets[j, i] <- gmt.list$genesets[[i]][[j]][1]
-      annotated.drugs <- c(annotated.drugs, gmt.list$genesets[[i]][[j]][1])
-    }
-  }
-  Drug.Sets <- as.data.frame(Drug.Sets)
-  annotated.drugs <- unique(annotated.drugs)
-  
-  # check class of inputs is as expected
-  testthat::expect_is(input.df, "data.frame")
-  testthat::expect_is(Drug.Sets, "data.frame")
-  
-  Samples <- colnames(input.df)[2]
-  Drug.Sets.All <- colnames(Drug.Sets)
-  
-  annotations <- matrix(
-    data = 0, nrow = nrow(input.df),
-    ncol = length(Drug.Sets.All)
-  )
-  colnames(annotations) <- Drug.Sets.All
-  
-  annotations <- as.data.frame(annotations)
-  
-  annotations <- cbind(input.df[, 1], annotations)
-  colnames(annotations) <- c(colnames(input.df)[1], Drug.Sets.All)
-  annotations <- as.matrix(annotations)
-  
-  # Find out how many cores are available
-  if (requireNamespace("parallel") &
-      requireNamespace("snow") &
-      requireNamespace("doSNOW")) {
-    cores <- parallel::detectCores()
-    if (cores[1] > 1) {
-      cl <- snow::makeCluster(cores[1] - 1) # cluster using all but 1 core
-      doSNOW::registerDoSNOW(cl) # register cluster
-    }
-  }
-  
-  num.hits.pathways <- as.data.frame(Drug.Sets.All)
-  num.hits.pathways$N_drugs <- NA
-  ### Annotate drug sets
-  for (j in seq_len(length(Drug.Sets.All))) {
-    temp.pathway <- Drug.Sets[, Drug.Sets.All[j]]
-    for (i in seq_len(nrow(annotations))) {
-      if (annotations[i, 1] %in% temp.pathway) {
-        annotations[i, j + 1] <- "X"
-      }
-    }
-    num.hits.pathways$N_drugs[j] <-
-      sum(annotations[, Drug.Sets.All[j]] == "X")
-  }
-  
-  ### Check if any drugs are not in any sets
-  unannotated.drugs <- c()
-  for (i in seq_len(nrow(annotations))) {
-    if (sum(annotations[i, 2:ncol(annotations)] == "X") == 0) {
-      unannotated.drugs <- c(unannotated.drugs, annotations[i, 1])
-    }
-  }
-  
-  ### Check if these unannotated drug names are a synonym for an annotated drug
-  if (convert.synonyms) {
-    # access drug synonyms
-    synonyms <- utils::read.csv(
-      paste0("https://raw.github.com/BelindaBGarana/DMEA/",
-             "shiny-app/Inputs/PRISM_drug_synonyms.csv")
-    )
-    replacements <- as.data.frame(unannotated.drugs)
-    replacements[, c("PRISM_drug_name",
-                     "PubChem_CID", "PubChem_synonyms")] <- NA
-    for (i in seq_len(length(unannotated.drugs))) {
-      # check if unannotated drug name is a CID for a PRISM drug
-      if (unannotated.drugs[i] %in% synonyms$PubChem_CID) {
-        replacements[i, c("PRISM_drug_name",
-                          "PubChem_CID", "PubChem_synonyms")] <-
-          synonyms[synonyms$PubChem_CID == unannotated.drugs[i], ]
-      } else {
-        # else check if unannotated drug is a synonym for a PRISM drug name
-        for (j in seq_len(nrow(synonyms))) {
-          temp.synonyms <- strsplit(synonyms$PubChem_synonyms[j], "[|]")
-          if (unannotated.drugs[i] %in% temp.synonyms) {
-            replacements[i, c("PRISM_drug_name",
-                              "PubChem_CID", "PubChem_synonyms")] <-
-              synonyms[j, c("PRISM_drug_name",
-                            "PubChem_CID", "PubChem_synonyms")]
-            break
-          }
-        }
-      }
-    }
-    unannotated.drugs <-
-      replacements[is.na(replacements$PRISM_drug_name), ]$unannotated.drugs
-    
-    # remove any drugs which were not replaced
-    replacements <- na.omit(replacements)
-    rm(synonyms)
-    
-    # replace drug names in rank list
-    for (i in seq_len(nrow(input.df))) {
-      if (input.df[i, 1] %in% replacements$unannotated.drugs) {
-        input.df[i, 1] <-
-          replacements[replacements$unannotated.drugs == input.df[i, 1],
-          ]$PRISM_drug_name
-      }
-    }
-    
-    # redo annotations
-    annotations <- matrix(
-      data = 0, nrow = nrow(input.df),
-      ncol = length(Drug.Sets.All)
-    )
-    colnames(annotations) <- Drug.Sets.All
-    
-    annotations <- as.data.frame(annotations)
-    
-    annotations <- cbind(input.df[, 1], annotations)
-    colnames(annotations) <- c(colnames(input.df)[1], Drug.Sets.All)
-    annotations <- as.matrix(annotations)
-    
-    ### Annotate drug sets
-    for (j in seq_len(length(Drug.Sets.All))) {
-      temp.pathway <- Drug.Sets[, Drug.Sets.All[j]]
-      for (i in seq_len(nrow(annotations))) {
-        if (annotations[i, 1] %in% temp.pathway) {
-          annotations[i, j + 1] <- "X"
-        }
-      }
-      num.hits.pathways$N_drugs[j] <-
-        sum(annotations[, Drug.Sets.All[j]] == "X")
-    }
-  } else {
-    replacements <- NULL
-  }
-  unannotated.input <- input.df[input.df[, 1] %in% unannotated.drugs, ]
-  
-  Drug.Sets.under <-
-    num.hits.pathways[num.hits.pathways$N_drugs < min.per.set, ]$Drug.Sets.All
-  Drug.Sets.over <-
-    num.hits.pathways[num.hits.pathways$N_drugs >= min.per.set,
-    ]$Drug.Sets.All
-  if (length(Drug.Sets.under) > 0) {
-    warning(paste0(
-      "Removing drug sets with less than ", min.per.set,
-      " drugs observed in data set"
-    ))
-    annotations <- annotations[, c(colnames(input.df)[1], Drug.Sets.All)]
-    
-    # only keep drug sets with >= min.per.set drugs
-    Drug.Sets.All <- Drug.Sets.over
-  }
-  colnames(num.hits.pathways)[1] <- "Drug_set"
-  if (length(Drug.Sets.over) < 2) {
-    stop("annotations for 2+ drug sets are required")
-  } # BG 2022-06-25
-  annotations <- as.data.frame(annotations)
-  input.df <- merge(input.df, annotations, by = colnames(input.df)[1])
-  input.df <- stats::na.omit(input.df)
-  rm(annotations)
-  
-  GSEA.Results <- matrix(data = NA, nrow = length(Drug.Sets.All), ncol = 8)
-  colnames(GSEA.Results) <- c(
-    "Rank_metric", "Drug_set", "ES", "NES",
-    "p_value", "Position_at_max", "FDR_q_value", "Leading_edge"
-  )
-  GSEA.Results <- as.data.frame(GSEA.Results)
-  GSEA.Results$Drug_set <- Drug.Sets.All
-  GSEA.Results$Rank_metric <- Samples
-  
-  ## Assuming first two columns in data table are drug names and
-  ## rank metric (e.g. Foldchange, SNR)
-  input.df[, Samples] <- as.numeric(as.character(input.df[, Samples]))
-  
-  # sort by descending order for the rank metric
-  input.df <- input.df[order(-input.df[, Samples]), ]
-  
-  # reorder row indices for counting in for loop below
-  rownames(input.df) <- seq_len(nrow(input.df))
-  ions <- nrow(input.df)
-  
-  # for plotting
-  ks_results_plot <- list()
-  positions.of.hits <- list()
-  
-  gene.list <- seq_len(ions)
-  rank_metric <- input.df[, Samples] # Save the rank metric
-  
-  pos_gene_set <- array(data = 0, dim = nrow(input.df), dimnames = NULL)
-  
-  ## Calculate Real KS Statistic with original input
-  message("calculating ES with original input")
-  for (i in seq_len(length(Drug.Sets.All))) {
-    pos_gene_set <- which(input.df[, Drug.Sets.All[i]] %in% c("X"))
-    KS_real <- GSEA.EnrichmentScore(gene.list, pos_gene_set,
-                                    weighted.score.type = score.weight,
-                                    correl.vector = rank_metric
-    )
-    
-    # store ES and positions
-    GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i],
-    ]$ES <- KS_real$ES
-    GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i],
-    ]$Position_at_max <- KS_real$arg.ES
-    ks_results_plot[[Drug.Sets.All[i]]] <- KS_real$RES
-    positions.of.hits[[Drug.Sets.All[i]]] <- pos_gene_set
-    
-    # identify leading edge elements
-    if (KS_real$ES <= 0) {
-      pos_leading_edge <- pos_gene_set[pos_gene_set >= KS_real$arg.ES]
-    } else if (KS_real$ES >= 0) {
-      pos_leading_edge <- pos_gene_set[pos_gene_set <= KS_real$arg.ES]
-    }
-    leading_edge <- input.df[pos_leading_edge, 1]
-    GSEA.Results[GSEA.Results$Drug_set == Drug.Sets.All[i], 
-    ]$Leading_edge <- paste(leading_edge, collapse = ", ")
-  }
-  Mountain.Plot.Info <- list(
-    MountainPlot = ks_results_plot,
-    Position.of.hits = positions.of.hits
-  )
-  rm(pos_gene_set)
-  rm(KS_real)
-  
-  ### tie permutations (NOT a null distribution)
-  if (ties) {
-    KSRandomArray_ties <- matrix(data = NA, nrow = nperm,
-                                 ncol = length(Drug.Sets.All))
-    num.Drug.Sets.all <- length(Drug.Sets.All)
-    `%dopar%` <- foreach::`%dopar%`
-    message("calculating ES with shuffled ties")
-    KSRandomArray_ties <- foreach::foreach(L = seq_len(nperm),
-                                           .combine = "rbind") %dopar% {
-                                             # randomly jitter list to shuffle ties
-                                             temp.input <- input.df[order(-input.df[, Samples], jitter(-input.df[, Samples])),]
-                                             rownames(temp.input) <- seq_len(nrow(temp.input)) # adding in case random result is due to nonsequential rownames?
-                                             gene.list <- rownames(temp.input)
-                                             
-                                             temp.KSRandomArray <- matrix(data = NA, nrow = 1,
-                                                                          ncol = num.Drug.Sets.all)
-                                             for (i in seq_len(length(Drug.Sets.All))) {
-                                               pos_gene_set <- which(temp.input[, Drug.Sets.All[i]] %in% c("X"))
-                                               
-                                               # calculate ES with shuffled ties
-                                               temp.KSRandomArray[, i] <- GSEA.EnrichmentScore(gene.list,
-                                                                                               pos_gene_set,
-                                                                                               weighted.score.type = score.weight,
-                                                                                               correl.vector = temp.input[, Samples]
-                                               )$ES
-                                             }
-                                             temp.KSRandomArray
-                                           }
-    colnames(KSRandomArray_ties) <- Drug.Sets.All
-    KSRandomArray_ties <- as.data.frame(KSRandomArray_ties)
-    
-    ### calculate ES & NES
-    # let ES = mean of ES tie distribution and NES = mean of NES tie distribution
-    GSEA.Results.ties <- matrix(data = NA, nrow = length(Drug.Sets.All), ncol = 11)
-    colnames(GSEA.Results.ties) <- c(
-      "Rank_metric", "Drug_set", "ES","ES_min","ES_max", "ES_sd",
-      "NES", "NES_min", "NES_max", "p_value", "FDR_q_value"
-    )
-    GSEA.Results.ties <- as.data.frame(GSEA.Results.ties)
-    GSEA.Results.ties$Drug_set <- Drug.Sets.All
-    GSEA.Results.ties$Rank_metric <- Samples
-    GSEA.Results.ties$ES <- colMeans(KSRandomArray_ties, na.rm = TRUE)
-    GSEA.Results.ties$ES_min <- apply(KSRandomArray_ties, 2, min)
-    GSEA.Results.ties$ES_max <- apply(KSRandomArray_ties, 2, max)
-    GSEA.Results.ties$ES_sd <- apply(KSRandomArray_ties, 2, sd)
-  }
-  
-  ### MOA permutations (null distribution)
-  KSRandomArray <- matrix(data = NA, nrow = nperm,
-                          ncol = length(Drug.Sets.All))
-  num.Drug.Sets.all <- length(Drug.Sets.All)
-  `%dopar%` <- foreach::`%dopar%`
-  
-  KSRandomArray <- foreach::foreach(L = seq_len(nperm),
-                                    .combine = "rbind") %dopar% {
-                                      temp.KSRandomArray <- matrix(data = NA, nrow = 1,
-                                                                   ncol = num.Drug.Sets.all)
-                                      for (i in seq_len(length(Drug.Sets.All))) {
-                                        # randomly sample drug set of same size as original set
-                                        numhits_pathway <- length(positions.of.hits[[Drug.Sets.All[i]]])
-                                        pos_gene_set <- sample(seq_len(ions), numhits_pathway)
-                                        
-                                        # calculate null enrichment score
-                                        temp.KSRandomArray[, i] <- GSEA.EnrichmentScore(gene.list,
-                                                                                         pos_gene_set,
-                                                                                         weighted.score.type = score.weight,
-                                                                                         correl.vector = rank_metric
-                                        )$ES
-                                      }
-                                      temp.KSRandomArray
-                                    }
-  colnames(KSRandomArray) <- Drug.Sets.All
-  KSRandomArray <- as.data.frame(KSRandomArray)
-  
-  ### normalize the GSEA distribution
-  KSRandomArray.Norm <- matrix(
-    data = NA, nrow = nrow(KSRandomArray),
-    ncol = ncol(KSRandomArray)
-  )
-  colnames(KSRandomArray.Norm) <- colnames(KSRandomArray)
-  KSRandomArray.temp <- 0
-  for (i in seq_len(ncol(KSRandomArray.Norm))) {
-    KSRandomArray.temp <- KSRandomArray[, i]
-    pos.temp <- KSRandomArray.temp[which(KSRandomArray.temp >= 0)]
-    neg.temp <-
-      KSRandomArray.temp[which(KSRandomArray.temp <= 0)] # BG OR EQUAL TO
-    
-    avg.pos <- mean(pos.temp)
-    avg.neg <- mean(neg.temp)
-    
-    norm.pos.temp <- pos.temp / avg.pos
-    norm.neg.temp <- neg.temp / avg.neg * -1
-    
-    norm.perms <- c(norm.pos.temp, norm.neg.temp)
-    
-    KSRandomArray.Norm[, i] <- norm.perms
-  }
-  
-  # Calculate GSEA NES and p-value
-  for (i in seq_len(length(Drug.Sets.All))) {
-    temp.gene.set <- Drug.Sets.All[i]
-    temp.perms <- KSRandomArray[, temp.gene.set]
-    temp.ES <- GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$ES
-    if (ties) {
-      temp.ES.tie <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES
-      temp.ES.tie.min <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES_min
-      temp.ES.tie.max <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$ES_max 
-    }
-    pos.perms <- temp.perms[which(temp.perms >= 0)] # BG OR EQUAL TO
-    neg.perms <- temp.perms[which(temp.perms <= 0)] # BG OR EQUAL TO
-    
-    # original input order
-    if (temp.ES >= 0) { # BG OR EQUAL TO
-      # p-value
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <-
-        signif(sum(pos.perms >= temp.ES) /
-                 length(pos.perms), digits = 3) # BG OR EQUAL TO
-      
-      # NES
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES <-
-        signif(temp.ES / mean(pos.perms), digits = 3)
-    } else { # BG OR EQUAL TO
-      # p-value
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <-
-        signif(sum(neg.perms <= temp.ES) /
-                 length(neg.perms), digits = 3) # BG OR EQUAL TO
-      
-      # NES
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES <-
-        signif(temp.ES / mean(neg.perms) * -1, digits = 3)
-    }
-    
-    # shuffled ties
-    if (ties) {
-      if (temp.ES.tie >= 0) {
-        # p-value
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$p_value <-
-          signif(sum(pos.perms >= temp.ES.tie.min) /
-                   length(pos.perms), digits = 3)
-        
-        # NES
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES <-
-          signif(temp.ES.tie / mean(pos.perms), digits = 3)
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min <-
-          signif(temp.ES.tie.min / mean(pos.perms), digits = 3)
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max <-
-          signif(temp.ES.tie.max / mean(pos.perms), digits = 3)
-      } else { # BG OR EQUAL TO
-        # p-val
-        GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$p_value <-
-          signif(sum(neg.perms <= temp.ES) /
-                   length(neg.perms), digits = 3) # BG OR EQUAL TO
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$p_value <-
-          signif(sum(neg.perms <= temp.ES.tie.max) /
-                   length(neg.perms), digits = 3)
-        
-        # NES
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES <-
-          signif(temp.ES.tie / mean(neg.perms) * -1, digits = 3)
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min <-
-          signif(temp.ES.tie.min / mean(neg.perms) * -1, digits = 3)
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max <-
-          signif(temp.ES.tie.max / mean(neg.perms) * -1, digits = 3)
-      } 
-    }
-  }
-  
-  # Calculate GSEA FDR
-  GSEA.Results <- GSEA.Results[!is.na(GSEA.Results$NES),]
-  GSEA.NES.perms <- as.vector(KSRandomArray.Norm[,GSEA.Results$Drug_set])
-  rm(KSRandomArray.Norm)
-  GSEA.NES.perms.pos <- GSEA.NES.perms[which(GSEA.NES.perms >= 0)]
-  GSEA.NES.perms.neg <-
-    GSEA.NES.perms[which(GSEA.NES.perms <= 0)] # BG OR EQUAL TO
-  rm(GSEA.NES.perms)
-  for (i in seq_len(length(GSEA.Results$Drug_set))) {
-    temp.gene.set <- GSEA.Results$Drug_set[i]
-    temp.NES <- GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES
-    if (ties) {
-      temp.NES.tie <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES
-      temp.NES.tie.min <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_min
-      temp.NES.tie.max <- GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$NES_max 
-    }
-    
-    # results for original input
-    if (temp.NES >= 0) { # BG OR EQUAL TO
-      percent.temp <-
-        sum(GSEA.NES.perms.pos >=
-              GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES) /
-        length(GSEA.NES.perms.pos) # BG OR EQUAL TO
-      percent.pos.stronger <-
-        sum(GSEA.Results$NES >=
-              GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$NES) /
-        sum(GSEA.Results$NES >= 0) # BG
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$FDR_q_value <-
-        ifelse(signif(percent.temp / percent.pos.stronger, digits = 3) < 1,
-               signif(percent.temp / percent.pos.stronger, digits = 3), 1
-        ) # BG
-    } else { # BG OR EQUAL TO
-      percent.temp <- sum(GSEA.NES.perms.neg <= temp.NES) /
-        length(GSEA.NES.perms.neg) # BG OR EQUAL TO
-      percent.neg.stronger <- sum(GSEA.Results$NES <= temp.NES) /
-        sum(GSEA.Results$NES <= 0) # BG
-      GSEA.Results[GSEA.Results$Drug_set == temp.gene.set, ]$FDR_q_value <-
-        ifelse(signif(percent.temp / percent.neg.stronger, digits = 3) < 1,
-               signif(percent.temp / percent.neg.stronger, digits = 3), 1
-        ) # BG
-    }
-    
-    # results for shuffled ties
-    if (ties) {
-      if (temp.NES.tie >= 0) {
-        percent.temp <-
-          sum(GSEA.NES.perms.pos >= temp.NES.tie.min) / length(GSEA.NES.perms.pos) # BG OR EQUAL TO
-        percent.pos.stronger <-
-          sum(GSEA.Results.ties$NES_max >= temp.NES.tie.min) / sum(GSEA.Results.ties$NES >= 0) # BG
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$FDR_q_value <-
-          ifelse(signif(percent.temp / percent.pos.stronger, digits = 3) < 1,
-                 signif(percent.temp / percent.pos.stronger, digits = 3), 1
-          ) # BG
-      } else {
-        percent.temp <- sum(GSEA.NES.perms.neg <= temp.NES.tie.max) / length(GSEA.NES.perms.neg) # BG OR EQUAL TO
-        percent.neg.stronger <- sum(GSEA.Results.ties$NES_min <= temp.NES.tie.max) / sum(GSEA.Results.ties$NES <= 0) # BG
-        GSEA.Results.ties[GSEA.Results.ties$Drug_set == temp.gene.set, ]$FDR_q_value <-
-          ifelse(signif(percent.temp / percent.neg.stronger, digits = 3) < 1,
-                 signif(percent.temp / percent.neg.stronger, digits = 3), 1
-          ) # BG
-      } 
-    } 
-  }
-  
-  if (requireNamespace("parallel") &
-      requireNamespace("snow") &
-      requireNamespace("doSNOW")) {
-    if (cores[1] > 1) {
-      snow::stopCluster(cl) # stop cluster
-      rm(cl)
-    }
-  }
-  
-  if (!ties) {
-    GSEA.Results.ties <- data.frame()
-  }
-  
-  return(list(
-    GSEA.Results = GSEA.Results,
-    GSEA.Results.ties = GSEA.Results.ties,
-    Mountain.Plot.Info = Mountain.Plot.Info,
-    ranking.metric = rank_metric,
-    removed.sets =
-      num.hits.pathways[num.hits.pathways$N_drugs < min.per.set, ],
-    replacements = replacements,
-    unannotated.drugs = unannotated.input
-  ))
-}
-
-# load mountain plot function
-gsea_mountain_plot <- function(GSEA.list, Sample.Name, Gene.Set.A,
-                               color = TRUE) {
-  if (color) {
-    color.palette <- c("red")
-  } else if (!color) {
-    color.palette <- c("black")
-  }
-  
-  GSEA.list <- GSEA.list
-  plotting.info <- GSEA.list$Mountain.Plot.Info
-  ES_profiles <- plotting.info$MountainPlot
-  position.of.hits <- plotting.info$Position.of.hits
-  
-  ranking.metric <- as.numeric(GSEA.list$ranking.metric)
-  
-  ES_GeneSetA <- ES_profiles[[Gene.Set.A]]
-  
-  pos.GeneSetA <- position.of.hits[[Gene.Set.A]]
-  
-  myName <- Gene.Set.A
-  
-  GSEA.results <- GSEA.list$GSEA.Results
-  GSEA.results <- GSEA.results[GSEA.results$Rank_metric == Sample.Name, ]
-  GSEA.results$p_value <- as.numeric(as.character(GSEA.results$p_value))
-  GSEA.results$FDR_q_value <- as.numeric(as.character(GSEA.results$FDR_q_value))
-  
-  gsea.normalized.enrichment.score <-
-    signif(GSEA.results[GSEA.results$Drug_set == myName, ]$NES, digits = 3)
-  gsea.p.value <-
-    signif(GSEA.results[GSEA.results$Drug_set == myName, ]$p_value,
-           digits = 3)
-  gsea.q.val <-
-    signif(GSEA.results[GSEA.results$Drug_set == myName, ]$FDR_q_value,
-           digits = 3)
-  
-  results.as.text <- paste(
-    "NES", gsea.normalized.enrichment.score, "\np-value:", gsea.p.value,
-    "\nq-value:", gsea.q.val
-  )
-  
-  gsea.hit.indices.A <- pos.GeneSetA
-  
-  gsea.es.profile.A <- ES_GeneSetA[gsea.hit.indices.A]
-  
-  ngenes <- length(ES_GeneSetA)
-  combined.ES <- c(ES_GeneSetA)
-  max.ES <- max(combined.ES)
-  min.ES <- min(combined.ES)
-  
-  mtn.plot <- NULL
-  mtn.plot <- ggplot2::ggplot() +
-    ggplot2::geom_line(
-      ggplot2::aes(
-        x = c(0, pos.GeneSetA, ngenes),
-        y = c(0, gsea.es.profile.A, 0)
-      ),
-      color = color.palette[1], size = 1
-    ) +
-    ggplot2::labs(x = NULL, y = "ES", title = myName) +
-    ggplot2::scale_x_continuous(expand = c(0, 0)) +
-    ggplot2::theme_bw() +
-    ggplot2::geom_hline(yintercept = 0, linetype = "dashed",
-                        color = "grey50") +
-    ggplot2::theme(
-      axis.text.x = ggplot2::element_blank(),
-      axis.ticks.x = ggplot2::element_blank(),
-      axis.ticks.length = ggplot2::unit(0, "pt"),
-      axis.title.x = ggplot2::element_blank(),
-      panel.grid = ggplot2::element_blank(),
-      plot.background = ggplot2::element_blank(),
-      plot.margin = ggplot2::unit(c(0, 0, 0, 0), "cm"),
-      plot.title = ggplot2::element_text(hjust = 0.5)
-    )
-  
-  if (!is.null(gsea.normalized.enrichment.score) &
-      length(gsea.normalized.enrichment.score) > 0) {
-    if (gsea.normalized.enrichment.score > 0) {
-      mtn.plot <- mtn.plot + ggplot2::annotate("text",
-                                               label = results.as.text, x = ngenes * 0.90,
-                                               y = max.ES * 0.70, color = "black"
-      )
-    } else if (gsea.normalized.enrichment.score < 0) {
-      mtn.plot <- mtn.plot + ggplot2::annotate("text",
-                                               label = results.as.text, x = ngenes * 0.10,
-                                               y = min.ES * 0.30, color = "black"
-      )
-    }
-  }
-  
-  hit.markers <- ggplot2::ggplot() +
-    cowplot::theme_nothing() +
-    ggplot2::theme(panel.border = ggplot2::element_rect(color = "black",
-                                                        fill = NA)) +
-    ggplot2::geom_col(ggplot2::aes(x = pos.GeneSetA, y = 1),
-                      color = color.palette[1],
-                      fill = color.palette[1], width = 0.75
-    ) +
-    ggplot2::labs(x = NULL, y = NULL) +
-    ggplot2::scale_y_continuous(expand = c(0, 0)) +
-    aplot::xlim2(mtn.plot)
-  
-  show.rank.metric <- ggplot2::ggplot() +
-    ggplot2::geom_line(ggplot2::aes(
-      x = seq_len(ngenes),
-      y = ranking.metric
-    ), color = "grey50") +
-    ggplot2::geom_area(ggplot2::aes(
-      x = seq_len(ngenes),
-      y = ranking.metric
-    ), fill = "grey50") +
-    ggplot2::labs(x = "Rank", y = "Rank Metric") +
-    ggplot2::theme_bw() +
-    ggplot2::theme(
-      panel.grid = ggplot2::element_blank(),
-      plot.title = ggplot2::element_blank(),
-      plot.margin = ggplot2::unit(c(0, 0, 0, 0), "cm")
-    ) +
-    aplot::xlim2(mtn.plot)
-  
-  assembled <- mtn.plot + hit.markers + show.rank.metric +
-    patchwork::plot_layout(ncol = 1, heights = c(2.5, 0.5, 2))
-  return(assembled)
-}
-
-summaryPlots <- function(EA, FDR = 0.25, n.top = 10, est.name = "Pearson.est", ties = FALSE) {
-  if (ties) {
-    plot.data <- na.omit(EA$GSEA.Results.ties)
-    significant.hits <- na.omit(EA$GSEA.Results.ties[which(EA$GSEA.Results.ties$FDR_q_value < FDR), ])
-  } else {
-    plot.data <- na.omit(EA$GSEA.Results) 
-    significant.hits <- na.omit(EA$GSEA.Results[which(EA$GSEA.Results$FDR_q_value < FDR), ])
-  }
-  
-  if (nrow(plot.data) > 0) {
-    if (nrow(plot.data[plot.data$p_value == 0, ]) > 0) {
-      plot.data[plot.data$p_value == 0, ]$p_value <- 0.00099
-    }
-    
-    if (nrow(plot.data[plot.data$FDR_q_value == 0, ]) > 0) {
-      plot.data[plot.data$FDR_q_value == 0, ]$FDR_q_value <- 0.00099
-    }
-    
-    # define x, y limits
-    limit.x <- ceiling(max(abs(as.numeric(plot.data$NES)), na.rm = TRUE))
-    limit.y <- ceiling(max(-as.numeric(log(plot.data$p_value, 10)), na.rm = TRUE))
-    
-    ## select results which meet FDR threshold and produce mountain plots
-    temp.plot <- list()
-    if (nrow(significant.hits) > 0) {
-      for (i in seq_len(nrow(significant.hits))) {
-        temp <- gsea_mountain_plot(
-          GSEA.list = EA, Sample.Name = est.name,
-          Gene.Set.A = significant.hits$Drug_set[i]
-        )
-        temp.plot[significant.hits$Drug_set[i]] <- list(temp)
-      }
-    } else {
-      warning("No enrichments met the FDR cut-off to produce mountain plots")
-    }
-    
-    # categorize data by significance level if there are significant hits
-    if (any(plot.data$FDR_q_value < FDR)) {
-      plot.data$Significance <- paste0("FDR > ", FDR)
-      plot.data[plot.data$FDR_q_value < FDR, ]$Significance <- paste0("FDR < ", FDR)
-      plot.data$Significance <- factor(plot.data$Significance,
-                                       levels = c(paste0("FDR < ", FDR),
-                                                  paste0("FDR > ", FDR)))
-      bar.data <- plot.data %>% slice_max(abs(NES), n=n.top)
-      bar.data <- bar.data[order(bar.data$NES),]
-      
-      volc <- ggplot2::ggplot(data = plot.data, aes(
-        x = NES, y = -log(p_value, 10),
-        color = Significance
-      )) +
-        ggplot2::geom_point(size = 4) +
-        ggrepel::geom_text_repel(
-          data = subset(plot.data, Significance == paste0("FDR < ", FDR)),
-          mapping = aes(label = Drug_set, size = I(6)), nudge_y = 0.25
-        ) +
-        ggplot2::scale_color_manual(
-          values = c("red", "azure4"), name = "Significance",
-          breaks = c(paste0("FDR < ", FDR), paste0("FDR > ", FDR))
-        ) +
-        ggplot2::xlim(-limit.x, limit.x) +
-        ggplot2::ylim(0, limit.y) +
-        ggplot2::xlab("Normalized Enrichment Score") +
-        ggplot2::ylab("-Log(p-value)") +
-        ggplot2::geom_vline(xintercept = 0, linetype = "solid", color = "grey",
-                            linewidth = 0.5) +
-        ggplot2::theme(
-          panel.border = element_rect(colour = "black", fill = NA, linewidth = 1),
-          axis.line = element_line(colour = "black", linewidth = 0.65),
-          legend.text = element_text(size = 20),
-          axis.text = element_text(size = 20),
-          axis.title = element_text(size = 26, face = "bold"),
-          panel.background = element_rect(
-            fill = "white", colour = "white", linewidth = 0.5,
-            linetype = "solid", color = "black"
-          ), text = element_text(size = 20),
-          legend.position = "bottom", legend.key = element_blank()
-        )
-      
-      bar <- ggplot2::ggplot(bar.data, aes(x=NES, y=Drug_set, fill = Significance)) + 
-        geom_bar(stat='identity') + ggplot2::theme(
-          panel.border = element_rect(colour = "black", fill = NA, linewidth = 1),
-          axis.line = element_line(colour = "black", linewidth = 0.65),
-          legend.text = element_text(size = 20),
-          axis.text = element_text(size = 20),
-          axis.title = element_text(size = 26, face = "bold"),
-          panel.background = element_rect(
-            fill = "white", colour = "white", linewidth = 0.5,
-            linetype = "solid", color = "black"
-          ), text = element_text(size = 20),
-          legend.position = "bottom", legend.key = element_blank()
-        ) + ggplot2::xlab("Normalized Enrichment Score") + 
-        ggplot2::ylab("") +
-        ggplot2::scale_fill_manual(
-          values = c("red", "azure4"), name = "Significance",
-          breaks = c(paste0("FDR < ", FDR), paste0("FDR > ", FDR))
-        ) 
-    } else {
-      plot.data$Significance <- paste0("FDR > ", FDR)
-      plot.data$Significance <- factor(plot.data$Significance,
-                                       levels = paste0("FDR > ", FDR))
-      bar.data <- plot.data %>% slice_max(abs(NES), n=n.top)
-      bar.data <- bar.data[order(bar.data$NES),]
-      
-      volc <- ggplot2::ggplot(data = plot.data,
-                              aes(x = NES, y = -log(p_value, 10))) +
-        ggplot2::geom_point(size = 4, color = "azure4") +
-        ggplot2::xlim(-limit.x, limit.x) +
-        ggplot2::ylim(0, limit.y) +
-        ggplot2::xlab("Normalized Enrichment Score") +
-        ggplot2::ylab("-Log(p-value)") +
-        ggplot2::geom_vline(xintercept = 0, linetype = "solid", color = "grey",
-                            linewidth = 0.5) +
-        ggplot2::theme(
-          panel.border = element_rect(colour = "black", fill = NA, linewidth = 1),
-          axis.line = element_line(colour = "black", linewidth = 0.65),
-          legend.text = element_text(size = 20),
-          axis.text = element_text(size = 20),
-          axis.title = element_text(size = 26, face = "bold"),
-          panel.background = element_rect(
-            fill = "white", colour = "white", linewidth = 0.5,
-            linetype = "solid", color = "black"
-          ), text = element_text(size = 20),
-          legend.position = "bottom", legend.key = element_blank()
-        )
-      
-      bar <- ggplot2::ggplot(bar.data, aes(x=NES, y=Drug_set, fill = Significance)) + 
-        geom_bar(stat='identity') + ggplot2::theme(
-          panel.border = element_rect(colour = "black", fill = NA, linewidth = 1),
-          axis.line = element_line(colour = "black", linewidth = 0.65),
-          legend.text = element_text(size = 20),
-          axis.text = element_text(size = 20),
-          axis.title = element_text(size = 26, face = "bold"),
-          panel.background = element_rect(
-            fill = "white", colour = "white", linewidth = 0.5,
-            linetype = "solid", color = "black"
-          ), text = element_text(size = 20),
-          legend.position = "bottom", legend.key = element_blank()
-        ) + ggplot2::xlab("Normalized Enrichment Score") + 
-        ggplot2::ylab("") +
-        ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) +
-        ggplot2::scale_fill_manual(
-          values = c("azure4"), name = "Significance",
-          breaks = c(paste0("FDR > ", FDR))
-        ) 
-    }
-    bar.data$name <- est.name
-    bg.theme <- ggplot2::theme(
-      legend.background = element_rect(), legend.position = "top",
-      legend.text = element_text(size = 14),
-      legend.key = element_blank(),
-      legend.title = element_text(size = 16),
-      axis.title.x = element_text(size = 20),
-      axis.text.x = element_text(size = 16, colour = "black"),
-      axis.title.y = element_text(size = 20),
-      axis.text.y = element_text(size = 16, colour = "black"),
-      plot.title = element_text(
-        lineheight = .8, face = "bold", size = 36
-      ),
-      panel.grid.major = element_blank(),
-      panel.grid.minor = element_blank(),
-      panel.border = element_rect(fill = NA),
-      panel.background = element_blank(),
-      axis.line = element_line(colour = "black"),
-      axis.ticks.x = element_line(colour = "black"),
-      axis.ticks.y = element_line(colour = "black")
-    )
-    dot <- ggplot2::ggplot(
-      bar.data,
-      ggplot2::aes(x = name, y = Drug_set, color = NES,
-                   size = -log10(FDR_q_value)
-      )
-    ) +
-      ggplot2::geom_point() +
-      ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) +
-      viridis::scale_color_viridis() +
-      bg.theme +
-      ggplot2::labs(
-        x = "", y = "",
-        color = "NES", size = "-log(FDR)"
-      )
-    
-    if (ties) {
-      dot.sd <- ggplot2::ggplot(
-        bar.data,
-        ggplot2::aes(x = name, y = Drug_set, color = NES,
-                     size = -log10(ES_sd)
-        )
-      ) +
-        ggplot2::geom_point() +
-        ggplot2::scale_y_discrete(limits = bar.data[order(bar.data$NES, decreasing = TRUE), ]$Drug_set) +
-        viridis::scale_color_viridis() +
-        bg.theme +
-        ggplot2::labs(
-          x = "", y = "",
-          color = "NES", size = "-log(ES SD)"
-        ) 
-    } else {
-      dot.sd <- NA
-    }
-  } else {
-    volc <- NA
-    bar <- NA
-    temp.plot <- list()
-    dot <- NA
-    dot.sd <- NA
-  }
-  return(list(volcano = volc, bar = bar, mtn = temp.plot, dot = dot, dot.sd = dot.sd))
-}
-
-drugSEA_ties <- function(data, gmt = NULL, drug = "Drug",
-                    rank.metric = "Pearson.est", set.type = "moa",
-                    direction.adjust = NULL, FDR = 0.25,
-                    num.permutations = 1000, stat.type = "Weighted",
-                    min.per.set = 6, n.top = 10, sep = "[|]",
-                    exclusions = c("-666", "NA", "na", "NaN", "NULL"),
-                    descriptions = NULL, convert.synonyms = FALSE, plots = TRUE, 
-                    ties = FALSE) {
-  # avoid unclear initialization
-  Drug_set <- NULL
-  NES <- NULL
-  Significance <- NULL
-  p_value <- NULL
-
-  # check class of input is as expected
-  testthat::expect_is(data, "data.frame")
-
-  ## remove any drugs with rank.metric = 0, NA
-  ## because signed ranks are required for enrichment analysis
-  data[, c(rank.metric)] <- as.numeric(data[, c(rank.metric)])
-  data <- data[data[, c(rank.metric)] != 0 & !is.na(data[, c(rank.metric)]), ]
-
-  ## check for duplicate entries for each drug
-  ## because only 1 rank metric is allowed per drug
-  drug.names <- unique(data[, c(drug)])
-  if (length(drug.names) < nrow(data)) {
-    stop("each drug must have only 1 rank.metric value")
-  }
-
-  ## if necessary, generate gmt object
-  if (is.null(gmt)) {
-    gmt <- as_gmt(data,
-      element.names = drug, set.names = set.type,
-      min.per.set, sep, exclusions, descriptions
-    )
-  }
-
-  ## if necessary, adjust rank metrics
-  if (length(direction.adjust) > 0) {
-    info <- dplyr::distinct(data[, c(drug, rank.metric, set.type)])
-    info$adjust <- 1
-    info[grep(direction.adjust, info[, c(set.type)],
-              value = TRUE), "adjust"] <- -1
-    info$adjusted.est <-
-      as.numeric(info[, c(rank.metric)]) * as.numeric(info$adjust)
-    input <- info[, c(drug, "adjusted.est")]
-    est.name <- paste0(rank.metric, " direction-adjusted")
-  } else {
-    input <- data[, c(drug, rank.metric)]
-    est.name <- rank.metric
-  }
-  colnames(input) <- c(drug, est.name)
-
-  ## perform enrichment analysis using GSEA_custom
-  message("Running enrichment analysis...")
-  EA <- GSEA_custom1(
-    input, gmt, num.permutations, stat.type,
-    min.per.set, convert.synonyms, ties
-  )
-  if (ties) {
-    result <- EA$GSEA.Results.ties
-    result.w.ties <- EA$GSEA.Results
-  } else {
-    result <- EA$GSEA.Results
-    result.w.ties <- data.frame()
-  }
-  
-  if (plots) {
-    ## produce volcano and bar plots
-    sumPlots <- summaryPlots(EA, FDR = FDR, n.top = n.top, est.name = est.name, ties = ties) 
-  } else {
-    sumPlots <- list("volcano" = NA, "bar" = NA, "mtn" = NA)
-  }
-
-  return(list(
-    gmt = gmt, result = result, result.w.ties = result.w.ties, 
-    mtn.plots = sumPlots$mtn,
-    volcano.plot = sumPlots$volcano, bar.plot = sumPlots$bar,
-    dot.plot = sumPlots$dot, dot.sd = sumPlots$dot.sd,
-    removed.sets = EA$removed.sets,
-    replaced.drugs = EA$replacements,
-    unannotated.drugs = EA$unannotated.drugs
-  ))
-}
diff --git a/R/mDEG.R b/R/mDEG.R
old mode 100755
new mode 100644
index 74bacd6..67d16a1
--- a/R/mDEG.R
+++ b/R/mDEG.R
@@ -1,28 +1,20 @@
-mDEG <- function(data.list, factor.info,
-                 feature.names = rep("Gene", length(data.list)), p = 0.05, 
+mDEG <- function(data.list, types, group.names = c("Diseased", "Healthy"), 
+                 group.samples = list(
+                   2:(0.5 * (ncol(data.list[[1]]) + 1)),
+                   (0.5 * (ncol(data.list[[1]]) + 1) + 1):ncol(data.list[[1]])
+                 ), group.names2 = NULL, group.samples2 = NULL, 
+                 feature.names = rep("Gene", length(types)), p = 0.05, 
                  FDR.features = 0.05, n.dot.features = 10) {
   #### Step 1. Check if formats are correct ####
   # check that there are as many types as data.list inputs
-  if (length(feature.names) != length(data.list)) {
-    stop("Length of feature.names vector must match that of data.list")
+  if (length(types) != length(data.list)) {
+    stop("Length of types vector must match that of data.list")
   }
-  types <- names(data.list)
-  
+
   #### Step 2. Differential expression analysis ####
-  if (length(levels(factor.info[,1])) != 2) {
-    stop("Exactly 2 levels are required for the first column of factor.info")
+  if (length(group.names) != 2) {
+    stop("Only 2 groups are allowed for differential expression analysis")
   } else {
-    # use parallel computing if possible
-    if (requireNamespace("parallel") &
-        requireNamespace("snow") &
-        requireNamespace("doSNOW")) {
-      cores <- parallel::detectCores() # number of cores available
-      if (cores[1] > 1) {
-        cl <- snow::makeCluster(cores[1] - 1) # cluster using all but 1 core
-        doSNOW::registerDoSNOW(cl) # register cluster
-      }
-    }
-    
     deg <- list()
     for (i in 1:length(types)) {
       # make sure there are no duplicated feature names
@@ -32,18 +24,60 @@ mDEG <- function(data.list, factor.info,
           "for each feature"
         ))
       } else {
-        # select annotated samples and set feature names as rownames
-        all.data.list <- data.list[[i]][,rownames(factor.info)]
+        ## separate data.list based on group (i.e., categorical phenotype)
+        # get column names for first set of groups
+        data.list1 <- as.data.frame(data.list[[i]][, group.samples[[1]]])
+        cols1 <- colnames(data.list1)
+        data.list2 <- as.data.frame(data.list[[i]][, group.samples[[2]]])
+        cols2 <- colnames(data.list2)
         
+        if (!is.null(group.names2) & !is.null(group.samples2)) {
+          # get column names for second set of groups
+          data.list1a <- as.data.frame(data.list[[i]][, group.samples2[[1]]])
+          data.list2a <- as.data.frame(data.list[[i]][, group.samples2[[2]]])
+          
+          # make sure samples have annotations for both sets of groups
+          cols1a <- colnames(data.list1a)
+          cols2a <- colnames(data.list2a)
+          cols1 <- cols1[cols1 %in% c(cols1a, cols2a)]
+          cols2 <- cols2[cols2 %in% c(cols1a, cols2a)]
+          
+          # refine data lists to shared samples
+          data.list1a <- NULL
+          data.list2a <- NULL
+          data.list1 <- data.list1[, cols1]
+          data.list2 <- data.list2[, cols2]
+          
+          # store group annotations
+          cols <- c(cols1, cols2)
+          factor.info <- as.data.frame(cols)
+          factor.info$f1 <- factor(c(rep(0, ncol(data.list1)), rep(1, ncol(data.list2))))
+          levels(factor.info$f1) <- make.names(group.names)
+          factor.info$f2 <- NA
+          factor.info[factor.info$cols %in% cols1a, ]$f2 <- 0
+          factor.info[factor.info$cols %in% cols2a, ]$f2 <- 1
+          factor.info$f2 <- as.factor(factor.info$f2)
+          levels(factor.info$f2) <- make.names(group.names2)
+          factor.info <- na.omit(factor.info)
+        } else {
+          # store group annotations
+          cols <- c(cols1, cols2)
+          factor.info <- as.data.frame(cols)
+          factor.info$f1 <- factor(c(rep(0, ncol(data.list1)), rep(1, ncol(data.list2))))
+          levels(factor.info$f1) <- make.names(group.names)
+        }
+
+        # combine data and set feature names as rownames
+        all.data.list <- cbind(data.list1, data.list2)
         rownames(all.data.list) <- data.list[[i]][ , feature.names[i]]
-        
+
         # create expression sets
         eset <- Biobase::ExpressionSet(as.matrix(all.data.list))
-        
+
         # log2 transformation if distribution isn't normal
         ex <- Biobase::exprs(eset)
         qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0),
-                                  na.rm = TRUE
+          na.rm = TRUE
         ))
         LogC <- (qx[5] > 100) ||
           (qx[6] - qx[1] > 50 && qx[2] > 0)
@@ -51,51 +85,32 @@ mDEG <- function(data.list, factor.info,
           ex[which(ex <= 0)] <- NaN
           Biobase::exprs(eset) <- log2(ex)
         }
-        
+
         # identify sample phenotypes and set up design matrix
-        eset$group <- factor.info[,1]
-        #levels(eset$group) <- levels(factor.info[,1])
-        if (ncol(factor.info) == 2) {
-          eset$batch <- factor.info[,2]
-          levels(eset$batch) <- levels(factor.info[,2])
+        eset$group <- factor.info$f1
+        if (!is.null(group.names2) & !is.null(group.samples2)) {
+          eset$batch <- factor.info$f2
           design <- stats::model.matrix(~ group + batch + 0, eset)
-          colnames(design)[1:2] <- make.names(substr(colnames(design)[1:2], 6, nchar(colnames(design)[1:2])))
-        } else if (ncol(factor.info) == 1) {
+          colnames(design)[1:2] <- levels(eset$group)
+        } else {
           design <- stats::model.matrix(~ group + 0, eset)
-          colnames(design) <- make.names(substr(colnames(design), 6, nchar(colnames(design))))
-        } else if (ncol(factor.info) == 3) {
-          eset$batch <- factor.info[,2]
-          eset$batch2 <- factor.info[,3]
-          levels(eset$batch) <- levels(factor.info[,2])
-          levels(eset$batch2) <- levels(factor.info[,3])
-          design <- stats::model.matrix(~ group + batch + batch2 + 0, eset)
-          colnames(design)[1:3] <- make.names(substr(colnames(design)[1:3], 6, nchar(colnames(design)[1:3])))
-        } else if (ncol(factor.info) > 3) {
-          eset$batch <- factor.info[,2]
-          eset$batch2 <- factor.info[,3]
-          eset$batch3 <- factor.info[,4]
-          levels(eset$batch) <- levels(factor.info[,2])
-          levels(eset$batch2) <- levels(factor.info[,3])
-          levels(eset$batch3) <- levels(factor.info[,4])
-          design <- stats::model.matrix(~ group + batch + batch2 + batch3 + 0, eset)
-          colnames(design)[1:4] <- make.names(substr(colnames(design)[1:4], 6, nchar(colnames(design)[1:4])))
+          colnames(design) <- levels(eset$group)
         }
-        
+
         # fit linear model
         fit <- limma::lmFit(eset, design)
-        
+
         # set up contrasts of interest and redo fit
-        cts <- paste(levels(factor.info[,1]), collapse = "-")
+        cts <- paste(colnames(design)[1:2], collapse = "-")
         cont.matrix <- limma::makeContrasts(contrasts = cts, levels = design)
         fit <- limma::contrasts.fit(fit, cont.matrix)
-        
+
         # calculate differential expression and statistics
         fit <- limma::eBayes(fit, 0.01)
         deg[[types[i]]] <- limma::topTable(fit,
-                                           adjust = "fdr",
-                                           number = nrow(fit)
+          adjust = "fdr",
+          number = nrow(fit)
         )
-        
         deg[[types[i]]][, feature.names[i]] <- rownames(deg[[types[i]]])
         colnames(deg[[types[i]]])[1] <- "Log2FC"
         deg[[types[i]]] <-
@@ -110,31 +125,16 @@ mDEG <- function(data.list, factor.info,
       }
     }
     
-    # compile DEG results across omics types if less than all of them are phospho
-    if (any(grepl("phospho", names(deg), ignore.case = TRUE))) {
-      compileDEGs <- all(grepl("phospho", names(deg), ignore.case = TRUE))
-    } else {
-      compileDEGs <- TRUE
-    }
-    if (length(types) > 1 & compileDEGs) {
+    # compile DEG results across omics types
+    if (length(types) > 1) {
       compiled.DEGs <- panSEA::compile_mDEG(deg, p, FDR.features, 
                                             n.dot.features)
     } else {
       compiled.DEGs <- NA
     }
-    
-    # stop cluster if relevant
-    if (requireNamespace("parallel") &
-        requireNamespace("snow") &
-        requireNamespace("doSNOW")) {
-      if (cores[1] > 1) {
-        snow::stopCluster(cl) # stop cluster
-        rm(cl)
-      }
-    }
-    
-    return(list(compiled.results = compiled.DEGs, all.results = deg
-    ))
+
+  return(list(compiled.results = compiled.DEGs, all.results = deg
+  ))
   }
 }
 
diff --git a/R/mDMEA.R b/R/mDMEA.R
old mode 100755
new mode 100644
index bd1dfed..d79e5e4
--- a/R/mDMEA.R
+++ b/R/mDMEA.R
@@ -13,7 +13,7 @@ mDMEA <- function(drug.sensitivity = "PRISM", gmt = "PRISM",
                   scatter.plot.type = "pearson", FDR.scatter.plots = 0.05,
                   xlab = "Weighted Voting Score", ylab = value, 
                   position.x = "min", position.y = "min", se = TRUE, 
-                  n.dot.sets = 10, ties = FALSE) {
+                  n.dot.sets = 10) {
   #### Step 1. Load data if necessary ####
   # get drug.sensitivity, gmt, and expression if PRISM/CCLE
   if (is.character(drug.sensitivity)) {
@@ -99,7 +99,7 @@ mDMEA <- function(drug.sensitivity = "PRISM", gmt = "PRISM",
   for (i in 1:length(types)) {
     message(paste("Running DMEA using", types[i], "data"))
 
-    DMEA.list[[types[i]]] <- panSEA::DMEA(
+    DMEA.list[[types[i]]] <- DMEA::DMEA(
       drug.sensitivity, gmt, expression[[i]],
       weights[[i]], value, sample.names,
       feature.names[i], weight.values[i],
@@ -109,7 +109,7 @@ mDMEA <- function(drug.sensitivity = "PRISM", gmt = "PRISM",
       descriptions, min.per.corr,
       scatter.plots, scatter.plot.type,
       FDR.scatter.plots, xlab, ylab,
-      position.x, position.y, se, ties
+      position.x, position.y, se
     )
 
     # merge correlation results with drug annotations if !is.null(drug.info)
diff --git a/R/mDMEA_cell_corr.R b/R/mDMEA_cell_corr.R
old mode 100755
new mode 100644
index f6d0f39..a65c2aa
--- a/R/mDMEA_cell_corr.R
+++ b/R/mDMEA_cell_corr.R
@@ -12,7 +12,7 @@ mDMEA_cell_corr <- function(drug.sensitivity = "PRISM", gmt = "PRISM",
                   scatter.plot.type = "pearson", FDR.scatter.plots = 0.05,
                   xlab = "Expression Correlation Estimate", ylab = value, 
                   position.x = "min", position.y = "min", se = TRUE, 
-                  n.dot.sets = 10, ties = FALSE) {
+                  n.dot.sets = 10) {
   #### Step 1. Load data if necessary ####
   # get drug.sensitivity, gmt, and expression if PRISM/CCLE
   if (is.character(drug.sensitivity)) {
@@ -108,7 +108,7 @@ mDMEA_cell_corr <- function(drug.sensitivity = "PRISM", gmt = "PRISM",
       descriptions, min.per.corr,
       scatter.plots, scatter.plot.type,
       FDR.scatter.plots, xlab, ylab,
-      position.x, position.y, se, ties
+      position.x, position.y, se
     )
 
     # merge correlation results with drug annotations if !is.null(drug.info)
diff --git a/R/mDMEA_gene_corr.R b/R/mDMEA_gene_corr.R
old mode 100755
new mode 100644
index 74078b7..2da4053
--- a/R/mDMEA_gene_corr.R
+++ b/R/mDMEA_gene_corr.R
@@ -1,7 +1,7 @@
 mDMEA_gene_corr <- function(gmt = "PRISM",
                   expression = as.list(rep("L1000", length(types))),
                   weights, types, value = "Perturbation",
-                  sample.names = "Drug",
+                  sample.names = colnames(expression[[1]])[1],
                   feature.names = rep("Gene", length(types)),
                   rank.metric = rep("Pearson.est", length(types)), p = 0.05,
                   FDR = 0.25, num.permutations = 1000, stat.type = "Weighted",
@@ -12,9 +12,25 @@ mDMEA_gene_corr <- function(gmt = "PRISM",
                   scatter.plot.type = "pearson", FDR.scatter.plots = 0.05,
                   xlab = "Expression", ylab = value, 
                   position.x = "min", position.y = "min", se = TRUE, 
-                  n.dot.sets = 10, ties = FALSE) {
+                  n.dot.sets = 10) {
   #### Step 1. Load data if necessary ####
-  # get gmt and expression if PRISM/L1000
+  # get drug.sensitivity, gmt, and expression if PRISM/CCLE
+  if (is.character(drug.sensitivity)) {
+    if (drug.sensitivity == "PRISM") {
+      message("Loading PRISM drug sensitivity AUC scores")
+      drug.sensitivity <- read.csv(file = paste0(
+        "https://raw.github.com/BelindaBGarana/",
+        "DMEA/shiny-app/Inputs/PRISM_drug_mean_AUC_6-23-21.csv"
+      )) # 481 cell lines
+      drug.sensitivity$X <- NULL
+    } else {
+      stop(paste(
+        "drug.sensitivity must be either 'PRISM' or data frame per",
+        "documentation"
+      ))
+    }
+  }
+
   if (is.character(gmt)) {
     if (gmt == "PRISM") {
       message("Loading PRISM drug mechanism of action annotations")
@@ -29,60 +45,32 @@ mDMEA_gene_corr <- function(gmt = "PRISM",
     }
   }
 
-  if ("L1000" %in% expression) {
-    message("Loading L1000")
-    # source: https://github.com/PNNL-CompBio/coderdata/blob/main/build/lincs/05-LINCS_perturbations.R
-    # identify URLs
-    #basename="https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE101406"
-    L1000 <- 'https://ftp.ncbi.nlm.nih.gov/geo/series/GSE101nnn/GSE101406/suppl/GSE101406%5FBroad%5FLINCS%5FL1000%5FLevel4%5FZSPCINF%5Fmlr12k%5Fn1667x12328.gctx.gz'
-    L1000.genes <- 'https://ftp.ncbi.nlm.nih.gov/geo/series/GSE101nnn/GSE101406/suppl/GSE101406%5FBroad%5FLINCS%5FL1000%5Fgene%5Finfo.txt.gz'
-    L1000.inst <- 'https://ftp.ncbi.nlm.nih.gov/geo/series/GSE101nnn/GSE101406/suppl/GSE101406%5FBroad%5FLINCS%5FL1000%5Finst%5Finfo.txt.gz'
-    
-    # download source sample & perturbation info
-    L1000.genes.info <- readr::read_delim(L1000.genes, "\t") # pr_gene_symbol, pr_gene_id
-    L1000.inst.info <- readr::read_delim(L1000.inst, "\t") # pert_iname; pert_type = "trt_cp" if drug, "ctl_vehicle" if DMSO; cell_id
-    L1000.inst.info <- L1000.inst.info[L1000.inst.info$pert_type == "trt_cp", ] # only keep drug treatments (remove DMSO controls)
-    
-    # download L1000 data
-    if (file.exists("L1000.gctx")) {
-      L1000.df <- cmapR::parse_gctx("L1000.gctx")
-    } else {
-      res<-download.file(L1000,'L1000.gctx.gz', mode="wb")
-      L1000.df<-cmapR::parse_gctx(R.utils::gunzip("L1000.gctx.gz")) 
-    }
-    
-    # put data into long format
-    L1000.long <- cmapR::melt_gct(L1000.df)
-    colnames(L1000.long) <- c("inst_id", "pr_gene_id", "data_value")
-    L1000.long$pr_gene_id <- as.numeric(L1000.long$pr_gene_id)
-    
-    # join with L1000.gene.info based on pr_gene_id;
-    # L1000.inst.info based on inst_id;
-    # keep only cell_id, pert_type, pert_iname, gene_symbol, data_value
-    L1000.full <- L1000.long |>
-      dplyr::left_join(L1000.genes.info) |>
-      dplyr::left_join(L1000.inst.info) |>
-      dplyr::select(cell_id,pert_type,pert_iname,pr_gene_symbol,data_value)|>
-      dplyr::distinct()
-    L1000.long <- NULL # save space
-    
-    # add relevant columns
-    L1000.full <- na.omit(L1000.full)
-    colnames(L1000.full)[1] <- "other_names" # match samples column name
-    colnames(L1000.full)[4] <- "gene_symbol" # match genes column name
-    colnames(L1000.full)[3] <- "chem_name"
-    L1000.full$data_type <- "transcriptomics"
-    L1000.full$source <- "Broad"
-    L1000.full$study <- "LINCS"
-    L1000.full$perturbation_type <- "drug" # all entries have pert_type="trt_cp"
+  if ("adherent CCLE" %in% expression) {
+    message("Loading adherent CCLE RNA-seq data version 19Q4")
+    download.file(
+      paste0(
+        "https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/",
+        "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin"
+      ),
+      destfile =
+        "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin"
+    )
+    load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_1-200.Rbin")
 
-    # aggregate across cell types
-    L1000.full <- reshape2::dcast(L1000.full, gene_symbol ~ chem_name, 
-                                  value.var = "data_value", fun.aggregate = mean)
-    colnames(L1000.full)[1] <- feature.names[1]
+    download.file(
+      paste0(
+        "https://raw.github.com/BelindaBGarana/DMEA/shiny-app/Inputs/",
+        "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin"
+      ),
+      destfile =
+        "Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin"
+    )
+    load("Normalized_adherent_CCLE_RNAseq_19Q4_samples_in_PRISM_201-327.Rbin")
 
-    for (i in which(expression == "L1000")) {
-      expression[[i]] <- L1000.full
+    RNA.df <- rbind(RNA.first200, RNA.rest)
+
+    for (i in which(expression == "adherent CCLE")) {
+      expression[[i]] <- RNA.df
     }
   }
 
@@ -91,13 +79,28 @@ mDMEA_gene_corr <- function(gmt = "PRISM",
     stop("Length of types vector must match that of weights list")
   }
 
+  # check that sample names are in drug.sensitivity data frame
+  if (!(sample.names %in% names(drug.sensitivity))) {
+    stop(paste("sample.names must match across drug.sensitivity and", 
+               "expression data frames"))
+  }
+
+  # check that sample names are in expression data frames
+  for (i in 1:length(types)) {
+    if (!(sample.names %in% names(expression[[i]]))) {
+      stop(paste("sample.names must match across drug.sensitivity and", 
+                 "expression data frames"))
+    }
+  }
+
   #### Step 2. Perform DMEA on each omics type ####
   DMEA.list <- list()
   for (i in 1:length(types)) {
     message(paste("Running DMEA using", types[i], "data"))
 
     DMEA.list[[types[i]]] <- panSEA::DMEA_gene_corr(
-      gmt, expression[[i]], weights[[i]], value, sample.names,
+      drug.sensitivity, gmt, expression[[i]],
+      weights[[i]], value, sample.names,
       feature.names[i], colnames(weights[[i]])[2],
       rank.metric[i], FDR, num.permutations,
       stat.type, drug.info, drug, set.type,
@@ -105,7 +108,7 @@ mDMEA_gene_corr <- function(gmt = "PRISM",
       descriptions, min.per.corr,
       scatter.plots, scatter.plot.type,
       FDR.scatter.plots, xlab, ylab,
-      position.x, position.y, se, ties
+      position.x, position.y, se
     )
 
     # merge correlation results with drug annotations if !is.null(drug.info)
diff --git a/R/mGSEA.R b/R/mGSEA.R
old mode 100755
new mode 100644
index f88e045..2343563
--- a/R/mGSEA.R
+++ b/R/mGSEA.R
@@ -6,7 +6,7 @@ mGSEA <- function(data.list, gmt = as.list(rep(
                   rank.var = rep("Log2FC", length(types)),
                   direction.adjust = NULL, p = 0.05, FDR = 0.25,
                   num.permutations = 1000, stat.type = "Weighted", 
-                  min.per.set = 6, n.dot.sets = 10, ties = FALSE) {
+                  min.per.set = 6, n.dot.sets = 10) {
   #### Step 1. Perform ssGSEA on each omics type ####
   ssGSEA.list <- list()
   for (i in 1:length(types)) {
@@ -16,7 +16,7 @@ mGSEA <- function(data.list, gmt = as.list(rep(
       data.list[[i]],
       gmt[[i]], feature.names[i], rank.var[i],
       direction.adjust, FDR,
-      num.permutations, stat.type, min.per.set, ties
+      num.permutations, stat.type, min.per.set
     )
   }
 
diff --git a/R/netSEA.R b/R/netSEA.R
old mode 100755
new mode 100644
diff --git a/R/panSEA.R b/R/panSEA.R
old mode 100755
new mode 100644
index dfbdfb6..e7b4565
--- a/R/panSEA.R
+++ b/R/panSEA.R
@@ -17,7 +17,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)),
                    scatter.plots = TRUE, scatter.plot.type = "pearson", 
                    drug.sensitivity = "PRISM",
                    expression = as.list(rep("adherent CCLE", length(types))),
-                   n.network.sets = 2*length(types), n.dot.sets = 10, scale = 5, ties = FALSE) {
+                   n.network.sets = 2*length(types), n.dot.sets = 10, scale = 5) {
   #### Step 1. Check if formats are correct ####
   # make sure that there are as many types as other inputs
   if (length(types) != length(gmt.features) |
@@ -77,7 +77,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)),
       ssGSEA.results <- panSEA::mGSEA(DEGs$all.results, gmt.features, types,
         feature.names, GSEA.rank.var, p = p, FDR = FDR, 
         num.permutations = num.permutations, stat.type = stat.type, 
-        min.per.set = min.per.set, n.dot.sets = n.dot.sets, ties = ties
+        min.per.set = min.per.set, n.dot.sets = n.dot.sets
       )
 
       # compile inputs & results for network graph
@@ -110,7 +110,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)),
                                       min.per.set = min.per.set,
                                       scatter.plots = scatter.plots, 
                                       scatter.plot.type = scatter.plot.type,
-                                      n.dot.sets = n.dot.sets, ties = ties
+                                      n.dot.sets = n.dot.sets
         ) 
       } else if (DMEA.type == "cell_corr") {
         DMEA.results <- 
@@ -123,7 +123,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)),
                                   min.per.set = min.per.set,
                                   scatter.plots = scatter.plots,
                                   scatter.plot.type = scatter.plot.type,
-                                  n.dot.sets = n.dot.sets, ties = ties
+                                  n.dot.sets = n.dot.sets
         ) 
       } else if (DMEA.type == "gene_corr") {
         DMEA.results <- 
@@ -136,7 +136,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)),
                                   min.per.set = min.per.set,
                                   scatter.plots = scatter.plots,
                                   scatter.plot.type = scatter.plot.type,
-                                  n.dot.sets = n.dot.sets, ties = ties
+                                  n.dot.sets = n.dot.sets
           ) 
       }
 
@@ -191,7 +191,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)),
                         GSEA.rank.var, p = p, FDR = FDR, 
                         num.permutations = num.permutations, 
                         stat.type = stat.type, min.per.set = min.per.set,
-                        n.dot.sets = n.dot.sets, ties = ties
+                        n.dot.sets = n.dot.sets
           )
 
         # compile inputs & outputs for network graph
@@ -225,7 +225,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)),
                           min.per.set = min.per.set, 
                           scatter.plots = scatter.plots,
                           scatter.plot.type = scatter.plot.type, 
-                          n.dot.sets = n.dot.sets, ties = ties
+                          n.dot.sets = n.dot.sets
             ) 
         } else if (DMEA.type == "cell_corr") {
           DMEA.results[[colnames(data.list[[1]])[j]]] <-
@@ -239,7 +239,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)),
                                     min.per.set = min.per.set, 
                                     scatter.plots = scatter.plots,
                                     scatter.plot.type = scatter.plot.type, 
-                                    n.dot.sets = n.dot.sets, ties = ties
+                                    n.dot.sets = n.dot.sets
             )
         } else if (DMEA.type == "gene_corr") {
           DMEA.results[[colnames(data.list[[1]])[j]]] <-
@@ -253,7 +253,7 @@ panSEA <- function(data.list, types, feature.names = rep("Gene", length(types)),
                                     min.per.set = min.per.set, 
                                     scatter.plots = scatter.plots,
                                     scatter.plot.type = scatter.plot.type, 
-                                    n.dot.sets = n.dot.sets, ties = ties
+                                    n.dot.sets = n.dot.sets
             )
         }
 
diff --git a/R/ssGSEA.R b/R/ssGSEA.R
old mode 100755
new mode 100644
index b7047bd..c57cf2d
--- a/R/ssGSEA.R
+++ b/R/ssGSEA.R
@@ -2,7 +2,7 @@ ssGSEA <- function(data, gmt = "msigdb_Homo sapiens_C2_CP:KEGG",
                    feature.names = colnames(data)[1],
                    rank.var = colnames(data)[2], direction.adjust = NULL,
                    FDR = 0.25, num.permutations = 1000,
-                   stat.type = "Weighted", min.per.set = 6, ties = FALSE) {
+                   stat.type = "Weighted", min.per.set = 6) {
   # get gmt if not provided
   if (is.character(gmt)) {
     if (grepl("msigdb", gmt, ignore.case = TRUE)) {
@@ -32,17 +32,14 @@ ssGSEA <- function(data, gmt = "msigdb_Homo sapiens_C2_CP:KEGG",
   }
 
   # run ssGSEA
-  results <- panSEA::drugSEA_ties(
+  results <- DMEA::drugSEA(
     data, gmt, feature.names, rank.var,
     "gs_name", direction.adjust, FDR,
-    num.permutations, stat.type, min.per.set, ties = ties
+    num.permutations, stat.type, min.per.set
   )
 
   # change "Drug_set" column names to "Feature_set"
   colnames(results$result)[2] <- "Feature_set"
-  if (ties) {
-    colnames(results$result.w.ties)[2] <- "Feature_set" 
-  }
   colnames(results$removed.sets)[1] <- "Feature_set"
   colnames(results$removed.sets)[2] <- "N_features"
 
@@ -50,7 +47,7 @@ ssGSEA <- function(data, gmt = "msigdb_Homo sapiens_C2_CP:KEGG",
   results$replaced.drugs <- NULL
 
   # change name of output referring to drugs to features
-  names(results)[length(results)] <- "unannotated.features"
+  names(results)[6] <- "unannotated.features"
 
   return(results)
 }
diff --git a/README.md b/README.md
old mode 100755
new mode 100644
diff --git a/app.R b/app.R
new file mode 100644
index 0000000..a9fc4cd
--- /dev/null
+++ b/app.R
@@ -0,0 +1,845 @@
+# Shiny app: multi-omics data analysis
+# accepts either 1 or 2 input groups
+# if 2 groups, performs differential expression analysis (limma::eBayes)
+# also performs enrichment analyses, including drug mechanism enrichment
+# analysis for each input data frame
+
+library(shiny)
+library(DT)
+library(panSEA)
+library(DMEA)
+library(data.table)
+library(dplyr)
+library(ggplot2)
+library(msigdbr)
+library(visNetwork)
+
+# set limit for upload file size
+MB.limit <- 180
+
+# set file names
+DEG.files <- c("Differential_expression_results.csv",
+               "Differential_expression_mean_results.csv",
+               "Differential_expression_venn_diagram.pdf",
+               "Differential_expression_correlation_matrix.pdf",
+               "Differential_expression_dot_plot.pdf")
+GSEA.files <- c("GSEA_results.csv",
+                "GSEA_mean_results.csv",
+                "GSEA_venn_diagram.pdf",
+                "GSEA_correlation_matrix.pdf",
+                "GSEA_dot_plot.pdf",
+                "GSEA_static_network_graph.pdf",
+                "GSEA_interactive_network.graph.html")
+DMEA.files <- c("DMEA_results.csv",
+                "DMEA_mean_results.csv",
+                "DMEA_venn_diagram.pdf",
+                "DMEA_correlation_matrix.pdf",
+                "DMEA_dot_plot.pdf",
+                "DMEA_static_network_graph.pdf",
+                "DMEA_interactive_network.graph.html")
+
+# Define UI for application
+ui <- fluidPage(
+  # Application title
+  titlePanel("panSEA: Multi-omic Set Enrichment Analysis"),
+
+  # Sidebar with a slider input for number of bins
+  sidebarLayout(
+    sidebarPanel(
+      # select 1 or 2 groups
+      radioButtons("Ngroups",
+        "How many groups/conditions would you like to analyze?",
+        choices = list(1, 2), selected = 1
+      ),
+
+      # keep track of last selection to add inputs if Ntypes is changed
+      # source: https://stackoverflow.com/questions/40631788/shiny-observe-triggered-by-dynamicaly-generated-inputs?noredirect=1
+      tags$script("$(document).on('change', '.dynamicSI select', function () {
+                              Shiny.onInputChange('lastSelectId',this.id);
+                              Shiny.onInputChange('lastSelect', Math.random());
+                             });"),
+      
+      # select # of input data sets
+      numericInput("Ntypes",
+        "How many omics data sets would you like to process?",
+        value = 2, min = 2
+      ),
+      
+      # allow input of multiple data sets
+      uiOutput("omics"),
+
+      # offer advanced settings
+      checkboxInput(inputId = "advanced", label = "Optional: advanced settings", value = FALSE),
+      conditionalPanel(
+        condition = "input.advanced",
+        textInput("g1Samples", "If 2 groups: columns containing samples belonging to group 1 (e.g., 2:4)"),
+        textInput("g2Samples", "If 2 groups: columns containing samples belonging to group 2 (e.g., 5:6)"),
+        selectInput(
+          "GSEA.rank", "If 2 groups: rank for GSEA",
+          c("Log2FC", "t"), "Log2FC"
+        ),
+        selectInput(
+          "DMEA.rank", "Rank for DMEA",
+          c("Pearson.est", "Spearman.est"), "Pearson.est"
+        ),
+        numericInput("n.min.per.set", "Minimum features or drugs per set", 6),
+        numericInput("n.dot.sets", "Number of sets for dot plots", 10),
+        numericInput("n.net.sets", "Number of sets for network graphs", 10),
+        sliderInput("p.cutoff", "P-value cutoff",
+          min = 0, max = 1, value = 0.05
+        ),
+        sliderInput("FDR.cutoff", "False discovery rate cutoff",
+          min = 0, max = 1, value = 0.25
+        ),
+        selectInput("drugSensType",
+          "Drug sensitivity data set",
+          choices = c(
+            "PRISM (adherent cancer cell lines)" = "prism",
+            "Other" = "other"
+          )
+        ),
+        conditionalPanel(
+          condition = "input.drugSensType == 'other'",
+          fileInput("drug.sens",
+            paste0("Upload a CSV file with sample names in column 1 and drug names as the rest of the column names (", MB.limit, " MB limit)"),
+            accept = ".csv"
+          ),
+          fileInput("drug.info",
+            paste0("Upload a CSV file with a column 'Drug' containing drug names and 'moa' containing set annotations (", MB.limit, " MB limit)"),
+            accept = ".csv"
+          )
+        )
+      ),
+
+      # include "Run" button
+      actionButton(inputId = "run", label = "Run"),
+
+      # including loading message
+      conditionalPanel(
+        condition = "input.run && !output.msg",
+        textOutput(outputId = "fyi")
+      ),
+
+      # indicate when run is completed
+      textOutput("msg")
+    ),
+
+    # Show a plot of the generated distribution
+    mainPanel(
+      # display plots in tabs
+      tabsetPanel(
+        tabPanel(
+          "Gene Set Enrichment Analysis: Dot Plot", plotOutput("GSEA.dot"),
+          conditionalPanel(
+            condition = "output.msg=='Run completed'",
+            downloadButton(outputId = "GSEA.dot.dwnld", 
+                           label = "Download dot plot of GSEA results")
+          )
+        ),
+        tabPanel(
+          "Drug Mechanism Enrichment Analysis: Dot Plot", 
+          plotOutput("DMEA.dot"),
+          conditionalPanel(
+            condition = "output.msg=='Run completed'",
+            downloadButton(outputId = "DMEA.dot.dwnld", 
+                           label = "Download dot plot of DMEA results")
+          )
+        ),
+        tabPanel(
+          "Gene Set Enrichment Analysis: Interactive Network Graph", 
+          visNetworkOutput("GSEA.int.net"),
+          conditionalPanel(
+            condition = "output.msg=='Run completed'",
+            downloadButton(outputId = "GSEA.int.net.dwnld", 
+                           label = "Download network graph of GSEA results")
+          )
+        ),
+        tabPanel(
+          "Drug Mechanism Enrichment Analysis: Interactive Network Graph", 
+          visNetworkOutput("DMEA.int.net"),
+          conditionalPanel(
+            condition = "output.msg=='Run completed'",
+            downloadButton(outputId = "DMEA.int.net.dwnld", 
+                           label = "Download network graph of GSEA results")
+          )
+        ),
+        # tabPanel(
+        #   "Gene Set Enrichment Analysis: Static Network Graph", 
+        #   plotOutput("GSEA.net"),
+        #   conditionalPanel(
+        #     condition = "output.msg=='Run completed'",
+        #     downloadButton(outputId = "GSEA.net.dwnld", 
+        #                    label = "Download network graph of GSEA results")
+        #   )
+        # ),
+        # tabPanel(
+        #   "Drug Mechanism Enrichment Analysis: Static Network Graph", 
+        #   plotOutput("DMEA.net"),
+        #   conditionalPanel(
+        #     condition = "output.msg=='Run completed'",
+        #     downloadButton(outputId = "DMEA.net.dwnld", 
+        #                    label = "Download network graph of GSEA results")
+        #   )
+        # ),
+        tabPanel(
+          "Gene Set Enrichment Analysis: Averaged Results", 
+          DT::dataTableOutput("GSEAResults"),
+          conditionalPanel(
+            condition = "output.msg=='Run completed'",
+            downloadButton(outputId = "GSEAResults.dwnld", 
+                           label = "Download averaged GSEA results")
+          )),
+        tabPanel(
+          "Drug Mechanism Enrichment Analysis: Averaged Results", 
+          DT::dataTableOutput("DMEAResults"),
+          conditionalPanel(
+            condition = "output.msg=='Run completed'",
+            downloadButton(outputId = "DMEAResults.dwnld", 
+                           label = "Download averaged DMEA results"))
+        )
+      ),
+
+      # output result files (.zip)
+      conditionalPanel(
+        condition = "output.msg=='Run completed'",
+        downloadButton(outputId = "results", label = "Download all results")
+      ),
+      uiOutput("info"),
+      textOutput("private"),
+      textOutput("refresh")
+    )
+  )
+)
+
+# Define backend
+server <- function(input, output) {
+  url <- a("https://github.com/belindabgarana/panSEA", href = "https://github.com/belindabgarana/panSEA")
+  output$info <- renderUI({
+    tagList("Please note that '0' values are < 0.001. For more information or to contact us, please visit: ", url)
+  })
+  output$private <- renderText({
+    "No user data is stored on our secure server, so your data will remain private."
+  })
+  output$refresh <- renderText({
+    "Please refresh your web browser after each analysis and format your inputs to match the examples on the 'How to Use' page at the URL above to avoid errors. You will also need to refresh this webpage after 5 minutes of inactivity."
+  })
+  output$fyi <- renderText({
+    "Running analysis... Please allow 1 to 5 minutes of run time"
+  })
+  options(shiny.maxRequestSize = MB.limit * 1024^2)
+  
+  # accept data inputs
+  output$omics <- renderUI({
+    # create list based on Ntypes
+    buttons <- as.list(1:input$Ntypes)
+
+    # create wellPanel for each input
+    div( class = "dynamicSI",
+         lapply(buttons, function(i) {
+           wellPanel(
+             helpText(paste0("Input omics data set #",i)),
+             selectInput(paste0("type",i),
+                         "Omics data type",
+                         choices = c(
+                           "Example (1 group): GSE66539 SKCM sensitive vs. resistant to vemurafenib",
+                           "Example (1 group): GSE31625 NSCLC sensitive vs. resistant to erlotinib",
+                           "Transcriptomics",
+                           "Proteomics",
+                           "Phospho-proteomics",
+                           "Acetyl-proteomics",
+                           "Metabolomics",
+                           "Lipidomics"
+                         )
+             ),
+             fileInput(paste0("data",i),
+                       paste0("Upload a CSV file (", MB.limit, " MB limit)"),
+                       accept = ".csv"
+             ),
+             textInput(paste0("featureName",i),
+                       "Column name containing feature names", "Gene"),
+              selectInput(paste0("gmtType",i),
+                         "Feature set annotations",
+                         choices = c(
+                           "MSigDB (gene sets)",
+                           "Kinase-substrate (substrate_site sets)",
+                           "HMDB (human metabolite sets)",
+                           "Lipid classes",
+                           "Other"
+                         )
+              ),
+             conditionalPanel(
+               condition = paste0("input.gmtType",i," == 'MSigDB (gene sets)'"),
+               textInput(paste0("species",i), "Species", "Homo sapiens"),
+               textInput(paste0("cat",i), "Category (e.g., H, C1, C2, ..., C8)", "C2"),
+               textInput(paste0("subcat",i), "Optional: sub-category (e.g., CGP, CP:KEGG, or CP:REACTOME for category C2)", "CP:KEGG"),
+               helpText("More info about MSigDB gene sets is available here: https://www.gsea-msigdb.org/gsea/msigdb/collections.jsp")
+             ),
+             conditionalPanel(
+               condition = paste0("input.gmtType",i," == 'Kinase-substrate (substrate_site sets)'"),
+               textInput(paste0("species",i), "Species", "human")
+              ),
+             conditionalPanel(
+               condition = paste0("input.gmtType",i," == 'Other'"),
+               fileInput(paste0("gmtInfo",i),
+                         paste0("Upload a CSV file (", MB.limit, " MB limit)"),
+                         accept = ".csv"
+               ),
+               textInput(paste0("feature",i), "Column name containing feature names (e.g., gene_symbol)"),
+               textInput(paste0("set",i), "Column name containing set names (e.g., gs_name)"),
+             ),
+             selectInput(paste0("exprType",i),
+                         "Expression data set to pair with drug sensitivity data",
+                         choices = c(
+                           "Adherent CCLE v19Q4" = "ccle",
+                           "Other" = "other"
+                         )
+             ),
+             conditionalPanel(
+               condition = paste0("input.exprType",i," == 'other'"),
+               fileInput(paste0("exprInfo",i),
+                         paste0("Upload a CSV file with sample names in column 1 and feature names as the rest of the column names (", MB.limit, " MB limit)"),
+                         accept = ".csv"
+               )
+             )
+           )
+         }
+         )
+        )
+  })
+  
+  observeEvent(input$run, {
+    # get input parameters
+    cat(file = stderr(), "About to get n.groups", "\n")
+    n.groups <- input$Ngroups
+    if (n.groups == 1) {
+      group.names <- "Diseased"
+    } else {
+      group.names <- c("Diseased", "Healthy")
+    }
+    n.types <- input$Ntypes
+    GSEA.rank.var <- rep(input$GSEA.rank, n.types)
+    DMEA.rank.var <- rep(input$DMEA.rank, n.types)
+    p <- input$p.cutoff
+    FDR <- input$FDR.cutoff
+    min.per.set <- input$n.min.per.set
+    drugSensType <- input$drugSensType
+    cat(file = stderr(), "About to get drug.sensitivity", "\n")
+    if (is.character(drugSensType)) {
+      if (drugSensType == "prism") {
+        drug.sensitivity <- "PRISM"
+      }
+    } else {
+      drug.sensitivity <- input$drug.sens
+    }
+    n.network.sets <- input$n.net.sets
+    n.dot.plot.sets <- input$n.dot.sets
+    cat(file = stderr(), "About to get groupSamples", "\n")
+    if (input$g1Samples != "" & input$g2Samples != "" &
+        n.groups == 2) {
+      groupSamples <- list(input$g1Samples, input$g2Samples)
+    } else if (input$g1Samples != "" & input$g2Samples == "" &
+               n.groups == 1) {
+      groupSamples <- list(input$g1Samples)
+    } else if (input$g2Samples != "" & input$g1Samples == "" &
+               n.groups == 1) {
+      groupSamples <- list(input$g2Samples)
+    } else {
+      groupSamples <- list(2)
+    }
+    cat(file = stderr(), "About to get gmt.drugs", "\n")
+    if (input$drugSensType == "prism") {
+      gmt.drugs <- "PRISM"
+    } else {
+      gmt.drugs <- DMEA::as_gmt(drug.info, min.per.set = min.per.set)
+    }
+    
+    # get input data
+    cat(file = stderr(), "About to get input", "\n")
+    gmt.features <- list()
+    data.list <- list()
+    expression <- list()
+    types <- c()
+    feature.names <- c()
+    for (i in 1:n.types){
+      # reformat gmt.features
+      cat(file = stderr(), "About to get info for MSigDB", "\n")
+      if (input[[paste0("gmtType",i)]] == "MSigDB (gene sets)") {
+        gmt.features[[i]] <- paste0(
+          "msigdb_", input[[paste0("species",i)]], "_",
+          input[[paste0("cat",i)]], "_", input[[paste0("subcat",i)]]
+        )
+        cat(file = stderr(), "About to make ksdb gmt", "\n")
+      } else if (input[[paste0("gmtType",i)]] == "Kinase-substrate (substrate_site sets)") {
+        ksdb <- read.csv(paste0("https://raw.githubusercontent.com/",
+                                "BelindaBGarana/panSEA/shiny-app/data/",
+                                "ksdb_20231101.csv"))
+        ksdb <- ksdb[ksdb$KIN_ORGANISM == input[[paste0("species",i)]], ]
+        ksdb$SUB_SITE <- paste0(ksdb$SUBSTRATE, ksdb$SUB_MOD_RSD, 
+                                collapse = "_")
+        gmt.features[[i]] <- DMEA::as_gmt(ksdb, "SUB_SITE", "KINASE", 
+                                          min.per.set = 6, 
+                                          descriptions = "KIN_ACC_ID")
+        cat(file = stderr(), "About to make metabolite gmt", "\n")
+      } else if (input[[paste0("gmtType",i)]] == "HMDB (human metabolite sets)") {
+        # based on hmdb v5.0 downloaded 20231220: https://hmdb.ca/downloads 
+        hmdb <- read.csv(paste0("https://raw.githubusercontent.com/",
+                                "BelindaBGarana/panSEA/shiny-app/data/",
+                                "ksdb_20231101.csv"))
+        gmt.features[[i]] <- 
+          DMEA::as_gmt(hmdb, "name", "direct_parent", min.per.set)
+        cat(file = stderr(), "About to make lipid gmt", "\n")
+      } else if (input[[paste0("gmtType",i)]] == "Lipid classes") {
+        # based on lipid MiniOn https://github.com/PNNL-Comp-Mass-Spec/Rodin/blob/master/R/02_lipid_miner.R
+        # https://pubmed.ncbi.nlm.nih.gov/30977807/
+        FattyAcyls<-c("EA", "carnitine","FAHFA", "WE" )
+        Prenol<- c("CoQ")
+        Sterol<- c("Cholesterol","CE")
+        Sphingolipids<- c("Cer","CerP","HexCer","SM","GM3","GD","PE-Cer","PI-Cer","Sulfatide","GM1","GM2","LacCer","GalCer","GD1", "GD3","GlcCer", "MIP2C","MIPC","GT3")
+        Glycerophospholipids<-c("PE", "PC", "PS", "PI", "PG", "PA", "CL","PIP","PIP2", "PIP3")
+        Glycerolipids<- c("TG","DG","MG","DGDG","MGDG","SQMG", "SQDG", "DGTS/A")
+        lipid.info <- data.frame(FattyAcyls, Prenol, Sterol, Sphingolipids, 
+                                 Glycerophospholipids, Glycerolipids)
+        lipid.info <- reshape2::melt(lipid.info, value.name = "lipid")
+        gmt.features[[i]] <- 
+          DMEA::as_gmt(lipid.info, "lipid", colnames(lipid.info)[1], 
+                       min.per.set)
+        cat(file = stderr(), "About to make custom gmt", "\n")
+      }else if (input[[paste0("gmtType",i)]] == "Other") {
+        custom.gmt.features <- read.csv(input[[paste0("gmtInfo",i)]]$datapath) 
+        gmt.features[[i]] <- 
+          DMEA::as_gmt(custom.gmt.features, 
+                       input[[paste0("feature",i)]], input[[paste0("set",i)]], 
+                       min.per.set)
+      }
+      
+      # read input files
+      cat(file = stderr(), "About to check for GSE66539 example", "\n")
+      if (input[[paste0("type",i)]] == "Example (1 group): GSE66539 SKCM sensitive vs. resistant to vemurafenib") {
+        data.list[[i]] <- read.csv(
+          paste0("https://raw.githubusercontent.com/BelindaBGarana/DMEA/",
+                 "shiny-app/Examples/Gene_signature/",
+                 "GSE66539_SKCM_sensitive_vs_resistant_to_vemurafenib",
+                 "/Filtered_gene_signature_no_duplicates.csv"))
+        cat(file = stderr(), "About to check for GSE31625 example", "\n")
+      } else if (input[[paste0("type",i)]] == "Example (1 group): GSE31625 NSCLC sensitive vs. resistant to erlotinib") {
+        data.list[[i]] <- read.csv(
+          paste0("https://raw.githubusercontent.com/BelindaBGarana/DMEA/",
+                 "shiny-app/Examples/Gene_signature/",
+                 "GSE31625_NSCLC_sensitive_vs_resistant_to_erlotinib",
+                 "/Filtered_gene_signature_no_duplicates.csv"))
+        data.list[[i]][ , 3] <- NULL
+        cat(file = stderr(), "About to get check for custom input", "\n")
+      } else {
+        data.list[[i]] <- read.csv(input[[paste0("data",i)]]$datapath)
+      }
+      
+      # adjust groupSamples if necessary
+      cat(file = stderr(), "About to adjust groupSamples if necessary", "\n")
+      if (groupSamples == 2 & n.groups == 2) {
+        groupSamples <- list(2:(0.5*(ncol(data.list[[1]])+1)), 
+                             (0.5*(ncol(data.list[[1]])+1)+1):ncol(data.list[[1]]))
+      }
+      cat(file = stderr(), "About to get expression data", "\n")
+      if (input[[paste0("exprType",i)]] == "ccle") {
+        expression[[i]] <- "adherent CCLE"
+      } else {
+        expression[[i]] <- read.csv(input[[paste0("exprInfo",i)]]$datapath)
+      }
+  
+      # compile other input parameters
+      types <- c(input[[paste0("type",i)]], types)
+      feature.names <- c(input[[paste0("featureName",i)]], feature.names)
+    }
+
+    # run panSEA
+    cat(file = stderr(), "About to run panSEA", "\n")
+    results <- panSEA::panSEA(
+      data.list, types, feature.names, GSEA.rank.var, DMEA.rank.var,
+      group.names, groupSamples, gmt.features, gmt.drugs, p, FDR, FDR.features,
+      num.permutations = 1000, stat.type = "Weighted", min.per.set,
+      scatter.plots = TRUE, scatter.plot.type = "pearson", drug.sensitivity,
+      expression, n.network.sets, n.dot.plot.sets
+    )
+
+    # output results
+    cat(file = stderr(), "About to output results", "\n")
+    if (length(group.names) == 2) {
+      output$results <- downloadHandler(
+        filename = function() {
+          paste0("panSEA_results_", Sys.Date(), ".zip")
+        },
+        content = function(file) {
+          # set file names
+          all.files <- c("Differential_expression_results.zip",
+                         "GSEA_results.zip", "DMEA_results.zip",
+                         "All_panSEA_results.rds"
+          )
+          
+          # generate DEG files
+          write.csv(results$mDEG.results$compiled.results$results,
+                    DEG.files[1], row.names = FALSE)
+          write.csv(results$mDEG.results$compiled.results$mean.results,
+                    DEG.files[2], row.names = FALSE)
+          ggplot2::ggsave(DEG.files[3], 
+                 results$mDEG.results$compiled.results$venn.diagram,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(DEG.files[4], 
+                 results$mDEG.results$compiled.results$corr.matrix,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(DEG.files[5], 
+                 results$mDEG.results$compiled.results$dot.plot,
+                 device = "pdf"
+          )
+          zip(zipfile = all.files[1], files = DEG.files)
+ 
+          
+          # generate GSEA files
+          write.csv(results$mGSEA.results$compiled.results$results,
+                    GSEA.files[1], row.names = FALSE)
+          write.csv(results$mGSEA.results$compiled.results$mean.results,
+                    GSEA.files[2], row.names = FALSE)
+          ggplot2::ggsave(GSEA.files[3], 
+                 results$mGSEA.results$compiled.results$venn.diagram,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(GSEA.files[4], 
+                 results$mGSEA.results$compiled.results$corr.matrix,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(GSEA.files[5], 
+                 results$mGSEA.results$compiled.results$dot.plot,
+                 device = "pdf"
+          )
+          results$mGSEA.network$static
+          dev.print(pdf, GSEA.files[6])
+          visNetwork::visSave(results$mGSEA.network$interactive, 
+                              GSEA.files[7])
+          zip(zipfile = all.files[2], files = GSEA.files)
+          
+          # generate DMEA files
+          write.csv(results$mDMEA.results$compiled.results$results,
+                    DMEA.files[1], row.names = FALSE)
+          write.csv(results$mDMEA.results$compiled.results$mean.results,
+                    DMEA.files[2], row.names = FALSE)
+          ggplot2::ggsave(DMEA.files[3], 
+                 results$mDMEA.results$compiled.results$venn.diagram,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(DMEA.files[4], 
+                 results$mDMEA.results$compiled.results$corr.matrix,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(DMEA.files[5], 
+                 results$mDMEA.results$compiled.results$dot.plot,
+                 device = "pdf"
+          )
+          results$mDMEA.network$static
+          dev.print(pdf, DMEA.files[6])
+          visNetwork::visSave(results$mDMEA.network$interactive, 
+                              DMEA.files[7])
+          zip(zipfile = all.files[3], files = DMEA.files)
+          
+          # save all results
+          saveRDS(results, all.files[4])
+          zip(zipfile = file, files = all.files)
+        }
+      )
+
+      output$GSEA.dot.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("GSEA_dot_plot_", Sys.Date(), ".pdf")
+        },
+        content = function(file) {
+          ggplot2::ggsave(file, results$mGSEA.results$compiled.results$dot.plot, 
+                 device = "pdf")
+        }
+      )
+      output$GSEA.dot <-
+        renderPlot({
+          results$mGSEA.results$compiled.results$dot.plot
+        })
+
+      output$DMEA.dot.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("DMEA_dot_plot_", Sys.Date(), ".pdf")
+        },
+        content = function(file) {
+          ggplot2::ggsave(file, results$mDMEA.results$compiled.results$dot.plot, 
+                 device = "pdf")
+        }
+      )
+      output$DMEA.dot <-
+        renderPlot({
+          results$mDMEA.results$compiled.results$dot.plot
+        })
+      
+      output$GSEA.int.net.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("GSEA_interactive_network_graph_", Sys.Date(), ".html")
+        },
+        content = function(file) {
+          visSave(results$mGSEA.network$interactive, file)
+        }
+      )
+      output$GSEA.int.net <-
+        renderVisNetwork({
+          results$mGSEA.network$interactive
+        })
+      
+      output$DMEA.int.net.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("DMEA_interactive_network_graph_", Sys.Date(), ".html")
+        },
+        content = function(file) {
+          visSave(results$mDMEA.network$interactive, file)
+        }
+      )
+      output$DMEA.int.net <-
+        renderVisNetwork({
+          results$mDMEA.network$interactive
+        })
+      
+
+      # output$GSEA.net.dwnld <- downloadHandler(
+      #   filename = function() {
+      #     paste0("GSEA_static_network_graph_", Sys.Date(), ".pdf")
+      #   },
+      #   content = function(file) {
+      #     results$mGSEA.network$static
+      #     dev.print(pdf, file)
+      #   }
+      # )
+      # output$GSEA.net <-
+      #   renderPlot({
+      #     results$mGSEA.network$static
+      #   })
+      # 
+      # output$DMEA.net.dwnld <- downloadHandler(
+      #   filename = function() {
+      #     paste0("DMEA_static_network_graph_", Sys.Date(), ".pdf")
+      #   },
+      #   content = function(file) {
+      #     results$mDMEA.network
+      #     dev.print(pdf, file)
+      #   }
+      # )
+      # output$DMEA.net <-
+      #   renderPlot({
+      #     results$mDMEA.network
+      #   })
+
+      output$GSEAResults.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("GSEA_mean_results_", Sys.Date(), ".csv")
+        },
+        content = function(file) {
+          write.csv(results$mGSEA.results$compiled.results$mean.results, file)
+        }
+      )
+      GSEA.results <- results$mGSEA.results$compiled.results$mean.results %>% 
+        dplyr::mutate_if(is.numeric, ~round(., 3))
+      output$GSEAResults <- DT::renderDataTable({
+        DT::datatable(GSEA.results
+                      # ,
+                      # options = list(order = list(list(2, 'desc')))
+                      )
+      })
+      
+      output$DMEAResults.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("DMEA_mean_results_", Sys.Date(), ".csv")
+        },
+        content = function(file) {
+          write.csv(results$mDMEA.results$compiled.results$mean.results, file)
+        }
+      )
+      DMEA.results <- results$mDMEA.results$compiled.results$mean.results %>% 
+        dplyr::mutate_if(is.numeric, ~round(., 3))
+      output$DMEAResults <- DT::renderDataTable({
+        DT::datatable(DMEA.results
+                      # ,
+                      # options = list(order = list(list(2, 'desc')))
+                      )
+      })
+      
+      output$msg <- renderText({
+        "Run completed"
+      })
+    } else if (n.groups == 1) {
+      output$results <- downloadHandler(
+        filename = function() {
+          paste0("panSEA_results_", Sys.Date(), ".zip")
+        },
+        content = function(file) {
+          # set file names
+          all.files <- c("GSEA_results.zip", "DMEA_results.zip",
+                         "All_panSEA_results.rds"
+          )
+        
+          # generate GSEA files
+          write.csv(results$mGSEA.results[[1]]$compiled.results$results,
+                    GSEA.files[1], row.names = FALSE)
+          write.csv(results$mGSEA.results[[1]]$compiled.results$mean.results,
+                    GSEA.files[2], row.names = FALSE)
+          ggplot2::ggsave(GSEA.files[3], 
+                 results$mGSEA.results[[1]]$compiled.results$venn.diagram,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(GSEA.files[4], 
+                 results$mGSEA.results[[1]]$compiled.results$corr.matrix,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(GSEA.files[5], 
+                 results$mGSEA.results[[1]]$compiled.results$dot.plot,
+                 device = "pdf"
+          )
+          results$mGSEA.network[[1]]$static
+          dev.print(pdf, GSEA.files[6])
+          visNetwork::visSave(results$mGSEA.network[[1]]$interactive, 
+                              GSEA.files[7])
+          zip(zipfile = all.files[2], files = GSEA.files)
+          
+          # generate DMEA files
+          write.csv(results$mDMEA.results[[1]]$compiled.results$results,
+                    DMEA.files[1], row.names = FALSE)
+          write.csv(results$mDMEA.results[[1]]$compiled.results$mean.results,
+                    DMEA.files[2], row.names = FALSE)
+          ggplot2::ggsave(DMEA.files[3], 
+                 results$mDMEA.results[[1]]$compiled.results$venn.diagram,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(DMEA.files[4], 
+                 results$mDMEA.results[[1]]$compiled.results$corr.matrix,
+                 device = "pdf"
+          )
+          ggplot2::ggsave(DMEA.files[5], 
+                 results$mDMEA.results[[1]]$compiled.results$dot.plot,
+                 device = "pdf"
+          )
+          results$mDMEA.network[[1]]$static
+          dev.print(pdf, DMEA.files[6])
+          visNetwork::visSave(results$mDMEA.network[[1]]$interactive, 
+                              DMEA.files[7])
+          zip(zipfile = all.files[3], files = DMEA.files)
+          
+          # save all results
+          saveRDS(results, all.files[4])
+          zip(zipfile = file, files = all.files)
+        }
+      )
+
+      output$GSEA.dot.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("GSEA_dot_plot_", Sys.Date(), ".pdf")
+        },
+        content = function(file) {
+          ggplot2::ggsave(file, results$mGSEA.results[[1]]$compiled.results$dot.plot, 
+                 device = "pdf")
+        }
+      )
+      output$GSEA.dot <-
+        renderPlot({
+          results$mGSEA.results[[1]]$compiled.results$dot.plot
+        })
+
+      output$DMEA.dot.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("DMEA_dot_plot_", Sys.Date(), ".pdf")
+        },
+        content = function(file) {
+          ggplot2::ggsave(file, results$mDMEA.results[[1]]$compiled.results$dot.plot, 
+                 device = "pdf")
+        }
+      )
+      output$DMEA.dot <-
+        renderPlot({
+          results$mDMEA.results[[1]]$compiled.results$dot.plot
+        })
+      
+      output$GSEA.int.net.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("GSEA_interactive_network_graph_", Sys.Date(), ".html")
+        },
+        content = function(file) {
+          visSave(results$mGSEA.network[[1]]$interactive, file)
+        }
+      )
+      output$GSEA.int.net <-
+        renderVisNetwork({
+          results$mGSEA.network[[1]]$interactive
+        })
+
+      output$DMEA.int.net.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("DMEA_interactive_network_graph_", Sys.Date(), ".html")
+        },
+        content = function(file) {
+          visSave(results$mDMEA.network[[1]]$interactive, file)
+        }
+      )
+      output$DMEA.int.net <-
+        renderVisNetwork({
+          results$mDMEA.network[[1]]$interactive
+        })
+      
+      # output$GSEA.net.dwnld <- downloadHandler(
+      #   filename = function() {
+      #     paste0("GSEA_static_network_graph_", Sys.Date(), ".pdf")
+      #   },
+      #   content = function(file) {
+      #     results$mGSEA.network[[1]]$static
+      #     dev.print(pdf, file)
+      #   }
+      # )
+      # output$GSEA.net <-
+      #   renderPlot({
+      #     results$mGSEA.network[[1]]$static
+      #   })
+
+      output$GSEAResults.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("GSEA_mean_results_", Sys.Date(), ".csv")
+        },
+        content = function(file) {
+          write.csv(results$mGSEA.results[[1]]$compiled.results$mean.results, 
+                    file)
+        }
+      )
+      GSEA.results <- results$mGSEA.results[[1]]$compiled.results$mean.results %>% 
+        dplyr::mutate_if(is.numeric, ~round(., 3))
+      output$GSEAResults <- DT::renderDataTable({
+        DT::datatable(GSEA.results
+                      # ,
+                      # options = list(order = list(list(2, 'desc')))
+                      )
+      })
+      
+      output$DMEAResults.dwnld <- downloadHandler(
+        filename = function() {
+          paste0("DMEA_mean_results_", Sys.Date(), ".csv")
+        },
+        content = function(file) {
+          write.csv(results$mDMEA.results[[1]]$compiled.results$mean.results, 
+                    file)
+        }
+      )
+      DMEA.results <- results$mDMEA.results[[1]]$compiled.results$mean.results %>% 
+        dplyr::mutate_if(is.numeric, ~round(., 3))
+      output$DMEAResults <- DT::renderDataTable({
+        DT::datatable(DMEA.results
+                      # ,
+                      # options = list(order = list(list(2, 'desc')))
+                      )
+      })
+      
+      output$msg <- renderText({
+        "Run completed"
+      })
+    }
+  })
+}
+
+# Run the application
+shinyApp(ui = ui, server = server)
diff --git a/data/gmt_ksdb_human.rds b/data/gmt_ksdb_human.rds
old mode 100755
new mode 100644
diff --git a/data/ksdb_20231101.csv b/data/ksdb_20231101.csv
old mode 100755
new mode 100644
diff --git a/man/.DS_Store b/man/.DS_Store
new file mode 100644
index 0000000..9df81b1
Binary files /dev/null and b/man/.DS_Store differ
diff --git a/man/DMEA_cell_corr.Rd b/man/DMEA_cell_corr.Rd
old mode 100755
new mode 100644
index 2f114a7..d331773
--- a/man/DMEA_cell_corr.Rd
+++ b/man/DMEA_cell_corr.Rd
@@ -20,7 +20,7 @@ DMEA_cell_corr(drug.sensitivity, gmt=NULL, expression, weights, value="AUC",
     exclusions=c("-666", "NA", "na", "NaN", "NULL"), descriptions=NULL,
     min.per.corr=3, scatter.plots=TRUE, scatter.plot.type="pearson",
     FDR.scatter.plots=0.05, xlab="Expression Correlation Estimate", ylab=value,
-    position.x="min", position.y="min", se=TRUE, ties=FALSE)
+    position.x="min", position.y="min", se=TRUE)
 }
 
 \arguments{
@@ -138,13 +138,10 @@ DMEA_cell_corr(drug.sensitivity, gmt=NULL, expression, weights, value="AUC",
   Must be "min", "mid", "max", or numeric. Default: "max".
   }
 
-  \item{se}{Logical operator describing whether or not to include the 95
-  percent confidence interval limits of the regression line on the scatter
-  plots. Default: TRUE.
-  }
-  
-  \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE.
-  }
+    \item{se}{Logical operator describing whether or not to include the 95
+    percent confidence interval limits of the regression line on the scatter
+    plots. Default: TRUE.
+    }
 }
 
 \value{
diff --git a/man/DMEA_gene_corr.Rd b/man/DMEA_gene_corr.Rd
old mode 100755
new mode 100644
index dbebaeb..693335c
--- a/man/DMEA_gene_corr.Rd
+++ b/man/DMEA_gene_corr.Rd
@@ -19,7 +19,7 @@ DMEA_gene_corr(gmt=NULL, expression, weights, value="Perturbation",
     exclusions=c("-666", "NA", "na", "NaN", "NULL"), descriptions=NULL,
     min.per.corr=3, scatter.plots=TRUE, scatter.plot.type="pearson",
     FDR.scatter.plots=0.05, xlab="Expression", ylab=value,
-    position.x="min", position.y="min", se=TRUE, ties=FALSE)
+    position.x="min", position.y="min", se=TRUE)
 }
 
 \arguments{
@@ -132,13 +132,10 @@ DMEA_gene_corr(gmt=NULL, expression, weights, value="Perturbation",
   Must be "min", "mid", "max", or numeric. Default: "max".
   }
 
-  \item{se}{Logical operator describing whether or not to include the 95
-  percent confidence interval limits of the regression line on the scatter
-  plots. Default: TRUE.
-  }
-  
-  \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE.
-  }
+    \item{se}{Logical operator describing whether or not to include the 95
+    percent confidence interval limits of the regression line on the scatter
+    plots. Default: TRUE.
+    }
 }
 
 \value{
diff --git a/man/WV.Rd b/man/WV.Rd
deleted file mode 100755
index 3a7b66b..0000000
--- a/man/WV.Rd
+++ /dev/null
@@ -1,97 +0,0 @@
-\name{WV}
-
-\alias{WV}
-
-\title{Weighted Voting
-}
-
-\description{Weights are multiplied by their expression values, then summed
-across all parameters (e.g., genes) for each sample or cell line to produce a
-score. Various types of expression data may be used (e.g., RNAseq, proteomics
-data).
-}
-
-\usage{
-WV(expression, weights, sample.names=colnames(expression)[1],
-        gene.names=colnames(weights)[1], weight.values=colnames(weights)[2])
-}
-
-\arguments{
-  \item{expression}{Data frame containing normalized gene expression with gene
-  symbols as column names, except for one column which contains sample names.
-  }
-
-  \item{weights}{Data frame with gene.names and weight.values (e.g.,
-  log2(fold-change) values). All gene.names must be present in the expression
-  data frame.
-  }
-
-  \item{sample.names}{Column name in expression data frame containing the sample
-  names. Default: colnames(expression)[1].
-  }
-
-  \item{gene.names}{Column name in weights data frame containing the gene
-  symbols. Default: colnames(weights)[1].
-  }
-
-  \item{weight.values}{Column name in weights data frame containing the weight
-  values (e.g., log2(fold-change) values). Default: colnames(weights)[2].
-  }
-}
-
-\value{
-  \item{scores}{Data frame with Weighted Voting scores for each sample name.}
-
-  \item{unused.weights}{Data frame with input weights not used for Weighted
-  Voting.}
-}
-
-\references{
-Garana, B.B., Joly, J.H., Delfarah, A. et al. Drug mechanism enrichment analysis
-improves prioritization of therapeutics for repurposing. BMC Bioinformatics 24,
-215 (2023). https://doi.org/10.1186/s12859-023-05343-8
-}
-
-\author{Belinda B. Garana
-}
-
-\section{Warning}{Make sure your weights have the same gene names as your
-expression data frame, and that your expression data frame is formatted with gene
-symbols along columns.}
-
-\examples{
-## Step 1: prepare gene weight data frame
-# create list of gene symbols
-Gene <- paste0("Gene_", seq(from = 1, to = 50))
-
-# by default, gene symbols are found in
-# the first column of your weights data frame
-weights <- as.data.frame(Gene)
-
-# give each gene a weight
-# by default, gene weight values are found in
-# the second column of your weights data frame
-weights$Rank_metric <- rnorm(length(Gene))
-
-## Step 2: prepare expression data frame
-# by default, column 1 of your expression data frame is
-# the column name from which sample names are gathered and
-# the column containing sample names in your drug sensitivity
-# data frame should have the same name
-
-# create list of sample names
-Sample_ID <- seq(from = 1, to = 21)
-
-# by default, column 1 of your expression data frame is
-# the column name from which sample names are gathered
-expression <- as.data.frame(Sample_ID)
-
-# give each gene values representative of normalized RNA expression
-# each gene is represented by a column in your expression data frame
-for(i in 1:length(Gene)){
-  expression[,c(Gene[i])] <- rnorm(length(Sample_ID), sd = 0.5)
-}
-
-## Step 3: run Weighted Voting to score each sample
-WV.test <- panSEA::WV(expression, weights)
-}
diff --git a/man/compile_mDEG.Rd b/man/compile_mDEG.Rd
old mode 100755
new mode 100644
diff --git a/man/compile_mDMEA.Rd b/man/compile_mDMEA.Rd
old mode 100755
new mode 100644
diff --git a/man/compile_mGSEA.Rd b/man/compile_mGSEA.Rd
old mode 100755
new mode 100644
diff --git a/man/drugSEA_ties.Rd b/man/drugSEA_ties.Rd
deleted file mode 100755
index 63c5506..0000000
--- a/man/drugSEA_ties.Rd
+++ /dev/null
@@ -1,157 +0,0 @@
-\name{drugSEA_ties}
-
-\alias{drugSEA_ties}
-
-\title{Drug Set Enrichment Analysis with Ties
-}
-
-\description{Using drug rank metrics and drug set annotations, drugSEA
-calculates the enrichment of drug sets allowing for the consideration of ties. 
-It can also produce plots and generate a gmt object for future enrichment analyses.
-}
-
-\usage{
-drugSEA_ties(data, gmt=NULL, drug="Drug", rank.metric="Pearson.est",
-        set.type="moa", direction.adjust=NULL, FDR=0.25,
-        num.permutations=1000, stat.type="Weighted", min.per.set=6,
-        sep = "[|]", exclusions = c("-666", "NA", "na", "NaN", "NULL"),
-        descriptions=NULL, convert.synonyms=FALSE, ties=FALSE)
-}
-
-\arguments{
-  \item{data}{Data frame containing rank metric for each drug.
-  }
-
-  \item{gmt}{Optional: gmt object containing drug sets (e.g., output from
-  GSA.read.gmt function from GSA package). If gmt is not provided, set.type
-  parameter must match a column name in data. Default: NULL.
-  }
-
-  \item{drug}{Column name in data containing the drug names. Default: "Drug".
-  }
-
-  \item{rank.metric}{Column name in data containing the metric for ranking
-  drugs. Default: "Pearson.est".
-  }
-
-  \item{set.type}{Column name in data containing the set membership information
-  for each drug. Optional unless using direction.adjust feature or gmt is not
-  provided. Default: "moa".
-  }
-
-  \item{direction.adjust}{Vector of conditions for set.type to identify which,
-  if any, estimates to multiply by -1 (e.g., c(" agonist", " activator")).
-  Default: NULL.
-  }
-
-  \item{FDR}{False discovery rate cut-off value to produce mountain plots for
-  significant enrichments. Default: 0.05.
-  }
-
-  \item{num.permutations}{Number of permutations to perform. Default: 1000.
-  }
-
-  \item{stat.type}{Kolmogorov-Smirnov statistic type. Must be either "Weighted"
-  (weight = 1) or "Classic" (weight = 0). Default: "Weighted".
-  }
-
-  \item{min.per.set}{The minimum number of drugs required per set. Default: 6.
-  }
-
-  \item{sep}{Character(s) to use for splitting drug set names. Optional unless
-  gmt is not provided. Default: "[|]".
-  }
-
-  \item{exclusions}{A vector of drug set names to be excluded from the
-  generated gmt. Optional unless gmt is not provided. Default: c("-666", "NA",
-  "na", "NaN", "NULL").
-  }
-
-  \item{descriptions}{Optional: column name in data containing descriptions for
-  each drug set. If not provided and gmt is also not provided, set.type will be
-  used for the descriptions instead. Default: NULL.
-  }
-
-  \item{convert.synonyms}{Logical operator describing whether or not to convert
-  unannotated drug names to synonyms for drugs in the PRISM database. Default:
-  FALSE.
-  }
-  
-  \item{ties}{Logical operator describing whether or not to shuffle the order of 
-  input drugs with tied rank values. Default: FALSE.
-  }
-}
-
-\value{
-  \item{gmt }{gmt object containing list of elements (genesets), set names
-  (geneset.names), and set descriptions (geneset.descriptions).}
-
-  \item{result }{Data frame containing enrichment analysis results for drug
-  sets. If ties, these results are shuffled to account for any tied drugs in input.}
-  
-  \item{result.w.ties }{Data frame containing enrichment analysis results 
-  using original input order.}
-
-  \item{mtn.plots }{ggplot object list of mountain plots for drug sets with
-  enrichments which meet the FDR threshold.}
-
-  \item{volcano.plot }{ggplot object for volcano plot summarizing enrichment
-  of all drug sets evaluated.}
-
-  \item{removed.sets }{Data frame containing any drug sets which had too few
-  elements to be evaluated and their number of elements.}
-
-  \item{replaced.drugs }{Data frame containing input drug names which were
-  replaced based on PubChem synonyms and their PubChem CID.}
-
-  \item{unannotated.drugs }{Data frame containing input drug names which were
-  not matched to a drug set and their ranks.}
-}
-
-\references{
-Garana, B.B., Joly, J.H., Delfarah, A. et al. Drug mechanism enrichment analysis
-improves prioritization of therapeutics for repurposing. BMC Bioinformatics 24,
-215 (2023). https://doi.org/10.1186/s12859-023-05343-8
-}
-
-\author{Belinda B. Garana, James H. Joly
-}
-
-\note{Mountain plots can be saved individually using:
-for(i in seq_len(length(drugSEA.output$mtn.plots))){
-ggsave(filename, drugSEA.output$mtn.plots[[i]])
-}
-
-Output gmt can be saved for future use as an R object using:
-saveRDS(DMEA.output$gmt, file)
-}
-
-\section{Warning}{Each drug must have 1 non-zero, numeric rank.metric value to
-be included in the analysis. NA and zero values will be omitted after coercing
-the rank.metric values to be of type "numeric". If no gmt is provided, then
-set.type must be provided in the input data. Either the gmt or set.type column
-must provide annotations for 2+ drug sets.
-
-If convert.synonyms=TRUE, an internet connection is required and the drug
-synonym conversion is fastest if the input drug names are PubChem CIDs.
-}
-
-\examples{
-## Step 1: prepare data frame containing rank metrics
-## and set annotations for each drug
-# Drug is our default name for the column containing drug names
-Drug <- paste0("Drug_", seq(from = 1, to = 24))
-
-data <- as.data.frame(Drug)
-
-# Pearson.est is our default name for the column containing drug ranks
-data$Pearson.est <- rnorm(length(Drug), sd = 0.25)
-
-# moa is our default name for the column containing drug set annotations
-data$moa <- rep(paste("Set", LETTERS[seq(from = 1, to = 4)]), 6)
-
-## Step 2: perform drugSEA and store results
-# if you use other column names for your data parameter,
-# then make sure to set drug, rank.metric, and set.type parameters
-drugSEA.test <- panSEA::drugSEA_ties(data)
-}
diff --git a/man/mDEG.Rd b/man/mDEG.Rd
old mode 100755
new mode 100644
index b4ac681..6d6cc95
--- a/man/mDEG.Rd
+++ b/man/mDEG.Rd
@@ -11,22 +11,48 @@ transformation is performed prior to analysis.
 }
 
 \usage{
-mDEG(data.list, factor.info, feature.names = rep("Gene", length(data.list)),
+mDEG(data.list, types, group.names=c("Diseased", "Healthy"), 
+  group.samples=list(2:(0.5 * (ncol(data.list[[1]]) + 1)),
+  (0.5 * (ncol(data.list[[1]]) + 1) + 1):ncol(data.list[[1]])), 
+  group.names2=NULL, group.samples2=NULL,
+  feature.names=rep("Gene", length(types)), 
   p=0.05, FDR.features=0.05, n.dot.features=10)
 }
 
 \arguments{
   \item{data.list}{List of data frames where each data frame has one column 
   containing feature names (e.g., gene symbols) and the rest of its columns 
-  having sample names as column names. List names will be interpreted as 
-  omics types (e.g., "global" or "phospho"). Non-numeric column will be 
-  assumed to be feature names (e.g., "Gene" or "SUB_SITE").
+  having sample names as column names.
   }
 
-  \item{factor.info}{Data frame where rownames are sample names found in each 
-  data frame of data.list, the first column is a contrast with 2 levels, and 
-  optionally there may be a second column to be included in the design matrix 
-  (e.g., sex or batch effect).}
+  \item{types}{Vector of character descriptions of each omics type (e.g., 
+  c("Transcriptomics", "Proteomics")).
+  }
+  
+  \item{group.names}{Vector of names for 2 sample groups. 
+  Default: c("Diseased", "Healthy").
+  }
+  
+  \item{group.samples}{List of column numbers or names corresponding to the 
+  group names. For example, if columns 2:4 correspond to the first group (e.g., 
+  "Diseased") and columns 5:7 correspond to the second group (e.g., "Healthy"), 
+  then group.samples would be list(2:4, 5:7). The order of samples must be the 
+  same across all data frames in the input data.list. Default: 
+  list(2:(0.5 * (ncol(data.list[[1]]) + 1)), 
+  (0.5 * (ncol(data.list[[1]]) + 1) + 1):ncol(data.list[[1]])).
+  }
+  
+  \item{group.names2}{Optional: vector of names for 2 sample groups intended 
+  for batch effects or other confounding factors (e.g., sex). Default: NULL.
+  }
+  
+  \item{group.samples2}{Optional: list of column numbers or names corresponding 
+  to group.names2. For example, if columns 2:4 correspond to the first group 
+  (e.g., "Batch1") and columns 5:7 correspond to the second group 
+  (e.g., "Batch2"), then group.samples2 would be list(2:4, 5:7). The order of 
+  samples must be the same across all data frames in the input data.list. 
+  Default: NULL.
+  }
   
   \item{feature.names}{Vector of column names containing feature names (e.g., 
   gene symbols) in each corresponding data frame in the input data.list. 
@@ -90,13 +116,9 @@ expr <- data.frame(Gene, Sample_1, Sample_2, Sample_3,
 expr2 <- data.frame(Gene, Sample_1, Sample_2, Sample_3, 
   Sample_4, Sample_5, Sample_6)
 
-# compile expression data into list with descriptive names
-data.list <- list("Transcriptomics" = expr, "Proteomics" = expr2)
-
-# prepare factor info for differential expression contrast
-factor.info <- data.frame("contrast" = c(rep(0, 3), rep(1, 3)))
-rownames(factor.info) <- colnames(expr)[2:ncol(expr)]
-
 ## Step 3: perform differential expression analysis
-mDEG.test <- panSEA::mDEG(data.list, factor.info)
+# by default, we assume the first half of samples (1-3) are "Diseased"
+# and the second half of samples (4-6) are "Healthy"
+mDEG.test <- panSEA::mDEG(list(expr, expr2), 
+  types = c("Transcriptomics", "Proteomics"))
 }
diff --git a/man/mDMEA.Rd b/man/mDMEA.Rd
old mode 100755
new mode 100644
index 716c288..4267d33
--- a/man/mDMEA.Rd
+++ b/man/mDMEA.Rd
@@ -24,7 +24,7 @@ mDMEA(drug.sensitivity="PRISM", gmt="PRISM",
   descriptions=NULL, min.per.corr=3, scatter.plots=TRUE, 
   scatter.plot.type="pearson", FDR.scatter.plots=0.05, 
   xlab="Weighted Voting Score", ylab=value, position.x="min", 
-  position.y="min", se=TRUE, n.dot.sets=10, ties=FALSE)
+  position.y="min", se=TRUE, n.dot.sets=10)
 }
 
 \arguments{
@@ -164,9 +164,6 @@ mDMEA(drug.sensitivity="PRISM", gmt="PRISM",
   in the dot plot. The top significant sets will be selected based on 
   abs(mean_NES) and p & FDR cutoff values. Default: 10.
   }
-  
-  \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE.
-  }
 }
 
 \value{
diff --git a/man/mDMEA_cell_corr.Rd b/man/mDMEA_cell_corr.Rd
old mode 100755
new mode 100644
index 225f04a..2c674d7
--- a/man/mDMEA_cell_corr.Rd
+++ b/man/mDMEA_cell_corr.Rd
@@ -23,7 +23,7 @@ mDMEA_cell_corr(drug.sensitivity="PRISM", gmt="PRISM",
   descriptions=NULL, min.per.corr=3, scatter.plots=TRUE, 
   scatter.plot.type="pearson", FDR.scatter.plots=0.05, 
   xlab="Expression Correlation Estimate", ylab=value, position.x="min", 
-  position.y="min", se=TRUE, n.dot.sets=10, ties=FALSE)
+  position.y="min", se=TRUE, n.dot.sets=10)
 }
 
 \arguments{
@@ -159,9 +159,6 @@ mDMEA_cell_corr(drug.sensitivity="PRISM", gmt="PRISM",
   in the dot plot. The top significant sets will be selected based on 
   abs(mean_NES) and p & FDR cutoff values. Default: 10.
   }
-  
-  \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE.
-  }
 }
 
 \value{
diff --git a/man/mDMEA_gene_corr.Rd b/man/mDMEA_gene_corr.Rd
old mode 100755
new mode 100644
index 95ceb56..4aaf5cd
--- a/man/mDMEA_gene_corr.Rd
+++ b/man/mDMEA_gene_corr.Rd
@@ -22,7 +22,7 @@ mDMEA_gene_corr(gmt="PRISM",
   descriptions=NULL, min.per.corr=3, scatter.plots=TRUE, 
   scatter.plot.type="pearson", FDR.scatter.plots=0.05, 
   xlab="Expression", ylab=value, position.x="min", 
-  position.y="min", se=TRUE, n.dot.sets=10, ties=FALSE)
+  position.y="min", se=TRUE, n.dot.sets=10)
 }
 
 \arguments{
@@ -152,9 +152,6 @@ mDMEA_gene_corr(gmt="PRISM",
   in the dot plot. The top significant sets will be selected based on 
   abs(mean_NES) and p & FDR cutoff values. Default: 10.
   }
-  
-  \item{ties}{Logical operator describing whether or not to permute order of drugs with tied ranks. Default: FALSE.
-  }
 }
 
 \value{
diff --git a/man/mGSEA.Rd b/man/mGSEA.Rd
old mode 100755
new mode 100644
index 1886126..6c36a4c
--- a/man/mGSEA.Rd
+++ b/man/mGSEA.Rd
@@ -13,7 +13,7 @@ mGSEA(data.list, gmt=as.list(rep("msigdb_Homo sapiens_C2_CP:KEGG", length(types)
   types, feature.names=rep("Gene", length(types)), 
   rank.var=rep("Log2FC", length(types)), direction.adjust=NULL, p=0.05, 
   FDR=0.25, num.permutations=1000, stat.type="Weighted", min.per.set=6, 
-  n.dot.sets=10, ties=FALSE)
+  n.dot.sets=10)
 }
 
 \arguments{
@@ -70,9 +70,6 @@ mGSEA(data.list, gmt=as.list(rep("msigdb_Homo sapiens_C2_CP:KEGG", length(types)
   in the dot plot. The top significant sets will be selected based on 
   abs(mean_NES) and p & FDR cutoff values. Default: 10.
   }
-  
-  \item{ties}{Logical operator describing whether or not to permute order of genes with tied ranks. Default: FALSE.
-  }
 }
 
 \value{
diff --git a/man/netSEA.Rd b/man/netSEA.Rd
old mode 100755
new mode 100644
diff --git a/man/panSEA.Rd b/man/panSEA.Rd
old mode 100755
new mode 100644
index 93b09e7..b3e6949
--- a/man/panSEA.Rd
+++ b/man/panSEA.Rd
@@ -22,7 +22,7 @@ panSEA(data.list, types, feature.names = rep("Gene", length(types)),
   gmt.drugs="PRISM", GSEA=TRUE, DMEA=TRUE, DMEA.type="WV", p=0.05, FDR=0.25, 
   FDR.features=0.05, min.per.set=6, drug.sensitivity="PRISM", 
   expression=as.list(rep("adherent CCLE", length(types))), 
-  n.network.sets=2*length(types), n.dot.sets=10, scale=5, ties=FALSE)
+  n.network.sets=2*length(types), n.dot.sets=10, scale=5)
 }
 
 \arguments{
@@ -164,9 +164,6 @@ panSEA(data.list, types, feature.names = rep("Gene", length(types)),
   \item{scale}{Numeric value to multiply by rank.var value to size vertices on 
   network graphs for visibility. Default: 5.
   }
-  
-  \item{ties}{Logical operator describing whether or not to permute order of genes with tied ranks. Default: FALSE.
-  }
 }
 
 \value{
diff --git a/man/ssGSEA.Rd b/man/ssGSEA.Rd
old mode 100755
new mode 100644
index aa7a613..1dedbf7
--- a/man/ssGSEA.Rd
+++ b/man/ssGSEA.Rd
@@ -10,7 +10,7 @@
 
 \usage{
 ssGSEA(data, gmt="msigdb_Homo sapiens_C2_CP:KEGG", direction.adjust=NULL, 
-FDR=0.25, num.permutations=1000, stat.type="Weighted", min.per.set=6, ties=FALSE)
+FDR=0.25, num.permutations=1000, stat.type="Weighted", min.per.set=6)
 }
 
 \arguments{
@@ -48,9 +48,6 @@ FDR=0.25, num.permutations=1000, stat.type="Weighted", min.per.set=6, ties=FALSE
   
   \item{min.per.set}{The minimum number of drugs required per set. Default: 6.
   }
-  
-  \item{ties}{Logical operator describing whether or not to permute order of genes with tied ranks. Default: FALSE.
-  }
 }
 
 \value{
diff --git a/panSEA.Rproj b/panSEA.Rproj
old mode 100755
new mode 100644
index eaa6b81..21a4da0
--- a/panSEA.Rproj
+++ b/panSEA.Rproj
@@ -15,4 +15,3 @@ LaTeX: pdfLaTeX
 BuildType: Package
 PackageUseDevtools: Yes
 PackageInstallArgs: --no-multiarch --with-keep.source
-PackageRoxygenize: rd,collate,namespace
diff --git a/vignettes/panSEA.Rmd b/vignettes/panSEA.Rmd
old mode 100755
new mode 100644
index fd483ab..519865c
--- a/vignettes/panSEA.Rmd
+++ b/vignettes/panSEA.Rmd
@@ -26,6 +26,9 @@ data which corresponds to the input omics data type or use the default CCLE
 RNA-seq data (version 19Q4) and PRISM drug screen of 327 adherent cancer cell 
 lines.
 
+# Citation
+To cite this package, please use:
+Garana, B.B., Joly, J.H., Delfarah, A. et al. Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing. BMC Bioinformatics 24, 215 (2023). https://doi.org/10.1186/s12859-023-05343-8
 
 # Installation
 To install this package directly from GitHub, start R and enter:
@@ -34,7 +37,7 @@ if (!require("devtools", quietly = TRUE)) {
   install.packages("devtools")
 }
 
-devtools::install_github("PNNL-CompBio/panSEA")
+devtools::install_github("BelindaBGarana/panSEA")
 ```
 
 If you are using Windows OS, you may need to change the code above to:
@@ -43,7 +46,7 @@ if (!require("devtools", quietly = TRUE)) {
   install.packages("devtools")
 }
 
-devtools::install_github("PNNL-CompBio/panSEA", build = FALSE)
+devtools::install_github("BelindaBGarana/panSEA", build = FALSE)
 ```
 
 # Case 1: 2 Groups (e.g., Diseased vs. Healthy)
@@ -160,10 +163,7 @@ If you were using real transcriptomic data, you could use the default
 gmt.genes or adjust it to query the MSigDB; you could also use the default 
 gmt.drugs, drug.sensitivity, and expression to query adherent CCLE RNA-seq data 
 (version 19Q4) and the PRISM drug screen
-
-__THIS DOESNT WORK__
-
-```{r, eval=FALSE}
+```{r}
 panSEA.2groups <- panSEA::panSEA(data.list, types, gmt.features = gmt.features, 
                                  gmt.drugs = gmt.drugs, 
                                  drug.sensitivity = drug.sensitivity, 
@@ -197,8 +197,7 @@ paste0("https://raw.githubusercontent.com/BelindaBGarana/",
 ```
 
 2. Run panSEA and examine enrichment results visually
-__Also doesn't work.__
-```{r, eval=FALSE}
+```{r}
 panSEA.1group <- panSEA::panSEA(data.list, types, 
 group.names = "Sensitive_vs_resistant_to_EGFRi", group.samples = list(2))